bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluasi Persepsi dan Kompetensi Pendidikan Interprofesional Mahasiswa di Rotasi Klinik
Authors: Prihanti Gita Sekar , Soemantri Diantha , Findyartini Ardi
Published: June 2022

Kolaborasi interprofesional terbukti meningkatkan kualitas pelayanan kesehatan. Pendidikan interprofesional (IPE) di tahap pendidikan akademik dan klinik penting untuk menanamkan kemampuan kolaborasi. Penelitian ini bertujuan untuk mengetahui persepsi dan kompetensi IPE mahasiswa sebelum dan sesudah IPE rotasi klinik. Penelitian ini merupakan penelitian potong lintang yang dilakukan pada bulan November 2020 hingga Januari 2021 di Fakultas Kedokteran dan Fakultas Ilmu Kesehatan Universitas Muhammadiyah Malang (FK-FIKES UMM). Pengambilan sampel dilakukan dengan consequtive sampling. Penelitian ini melibatkan 278 mahasiswa dari tiga program studi yaitu, 152 mahasiswa kedokteran (54,7%), 80 farmasi (28,8%) dan 46 keperawatan (16,5%). IPE di rotasi klinik berlangsung selama dua minggu menggunakan metode pembelajaran aktif. Persepsi IPE diukur menggunakan Interdisciplinary Education Perception Scale (IEPS) sedangkan Interprofessional Collaborative Competency Attainment Survey (ICASS) untuk menilai kompetensi IPE sebelum dan sesudah IPE. Hasil menunjukkan bahwa jenis kelamin (p=0,033) dan persepsi (p=0,000) mempengaruhi kompetensi IPE sesudah IPE. Tidak didapatkan perbedaan persepsi dan kompetensi IPE antar profesi sebelum maupun sesudah IPE, namun semua mahasiswa mengalami peningkatan persepsi dan kompetensi secara bermakna. Di awal pembelajaran, persepsi (61,29±6,537) dan kompetensi IPE (121,92±14,039) mahasiswa kedokteran berada di urutan kedua setelah keperawatan. Setelah IPE, persepsi mahasiswa kedokteran menempati urutan tertinggi (65,22±8,63) sedangkan kompetensi IPE mahasiswa kedokteran berada di urutan terendah (126,08±4,345) dibandingkan dua kelompok lain. Jenis kelamin dan persepsi berperan penting untuk mempengaruhi kompetensi IPE. Upaya berkelanjutan diperlukan untuk membangun persepsi IPE agar dapat meningkatkan kompetensi IPE sehingga menghasilkan kolaborasi yang baik.
Studi Penggunaan Obat Anti Tuberkulosis (OAT) Tahap Lanjutan pada Pasien Baru BTA Positif
Authors: Fortuna Tista Ayu , Rachmawati Hidajah , Hasmono Didik , Karuniawati Hidayah
Published: June 2022

Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. Tuberculosis will cause pain and death if not treated properly. OAT (Antituberculosis Drugs) is a treatment for tuberculosis patients. OAT has different dosage regimens and types of drugs. Treatment of TB patients consists of two phases (intensive and continuation phases). The continuation phase was at to kill dormant bacteria to prevent recurrence in patients. The purpose of this study was to determine and evaluate the pattern of using OAT in patients newly diagnosed rwith smear-positive at the continuation phase. This study is an observational descriptive study with results showing that the pattern of using OAT-KDT in patients was 89% and OAT-Separated was 11%. The pattern of using the OAT-KDT dose was 1x3 2KDT tablets. Another combination of antibiotics given to the patient is cotrimoxazole at a dose of 1x960mg. The side effect of OAT is an increase in serum transaminase and nausea each with a percentage of 23%. Based on the research, it can be concluded that the pattern of using OAT in Tuberculosis patients has followed the guidelines for the management of Tuberculosis treatment.
Cytotoxic and Antiproliferation Activity of n-Hexane Fraction of Avocado seed (Persea americana Mill.) on MCF7 cell
Authors: Rahwawati Juwita , Maryati Maryati , Yuliani Ratna
Published: June 2022

Avocado seeds, which often end up as food waste, have many health benefits, including anticancer activity. This study aimed to determine the potential cytotoxic activity of avocado seeds against breast cancer cells, MCF7. Avocado seeds were macerated with 96% ethanol and fractionated with n-hexane, chloroform, and ethyl acetate as solvents. Cytotoxic activity of the extract and fractions was tested using the MTT method, while antiproliferation activity and apoptosis of the n-hexane fraction were tested using the doubling time and double staining methods, respectively. The selectivity of the n-hexane fraction was also determined. The results showed that the extract and n-hexane fraction of avocado seeds had cytotoxic activity on MCF7 with IC50 values of 211.2±25 and 47.87±1.5 µg/mL, respectively. The cytotoxic activity of the n-hexane fraction was selective (Selectivity Index = 4.73). The fraction can extend the doubling time to 76.54-77.41 hours. The double staining test results showed red fluorescence in the cells, indicating the apoptosis of MCF7 cells. The n-hexane fraction of avocado seed extract has the potential to be developed as an anticancer therapeutic agent.
Bilinguismo para surdos: Um olhar histórico, social, educacional e linguístico
Authors: Silva Kleber Aparecido da , Guedes Sônia Margarida Ribeiros , Dias Tatiana Rosa Nogueira , Tanzi Neto Adolfo , Tuxi Patrícia , Teixeira Cyntia Moraes
Published: June 2022

Apesar da importância da língua de sinais para os surdos, ela veio a ser reconhecida como língua em 1960, através do trabalho desenvolvido por Stokoe com a publicação do Dicionário de Língua de Sinais Americana. No Brasil, o reconhecimento da Língua Brasileira de Sinais (Libras) ocorreu recentemente em 2002, com a Lei de Libras, n. 10.436. A importância do contato com língua para as crianças surdas é essencial assim como para qualquer criança ouvinte. As crianças, no convívio com a comunidade linguística, se relacionam, falam e se comunicam em sua língua materna, aprendida com rapidez até os cinco anos de idade. Historicamente, isso não tem sido uma realidade para as crianças surdas privadas do contato com a língua de sinais. O diálogo entre direito e cidadania, direito e diversidade, direito e valorização humana, direito e escolarização de qualidade, há anos faz parte de momentos notadamente importantes na luta pelos direitos dos surdos. Reconhecer e aceitar a Língua de Sinais é um dos passos da luta pelos direitos à educação igual para todos, valores propostos pela educação inclusiva, herança da modernidade e gradual conquista aos direitos humanos. É preciso também aceitar e considerar a cultura, a identidade, a visão de mundo do sujeito surdo; assim como a sua segunda língua, no Brasil, a Língua Portuguesa.  Os esforços, a consolidação e o êxito de uma educação bilíngue para surdos se fazem, portanto, irreversíveis. Com a finalidade de refletir, analisar e problematizar as práticas com educação dos surdos, é que se propõe esta temática: "Bilinguismo para surdos: um olhar social, educacional e linguístico". Buscamos com isso trazer experiências e discussões sobre as práticas bilíngues em escolas do Brasil e de outros países, refletir sobre as necessidades sociais, educacionais e linguísticas dos surdos assim como os determinantes históricos, sociais, linguísticos e culturais que influenciam na educação bilíngue dos surdos.
Response: Lynch, J. and Porcellato, A. (2020) The Case for an Aviation English Screening Tool for US Flight Schools The Especialist 41, 4
Authors: Response - Latitude Team Latitude Aviation English Services
Published: June 2022

We enjoyed reading your paper, The Case for an Aviation English Screening Tool for US Flight Schools, in the Especialist. Not only is it encouraging to see more focus on this area which has been given scant attention over the years, but we were interested to see Checkpoint discussed for the first time. It is gratifying that you recognise Checkpoint’s strengths, as well as setting out areas which you believe could be improved.
Digital technologies and the oral production development in ELT: Echoing worldwide teacher's voice
Authors: Rio Marlon
Published: June 2022

Oral production development has been overemphasized to be one of the hardest ones, considering the multiple hindrances coming alongside its development (OSBORN et al., 2008). Similarly, there have been some initiatives from worldwide English teachers bringing contextually meaningful solutions to solve such  issues (POP et al., 2011; SONG, 2009). One of them has been vowed to be digital technologies, which would work, under a sociocultural perspective, as a potential learning and mediational tool (JOHNSON, 2009). This article, thence, displays an initial research carried out with thirty English teachers coming from thirteen countries. They were given the chance to voice their experiences regarding the use of digital technologies in developing the oral production. Preliminarily results demonstrate teachers’ will to make more often the use of digital technologies in the development of the oral production of their students, albeit many of them do not seemingly have the suitable knowledge to properly apply the learning potentialities of such digital tools. The teachers also claim to have already had both positive and negative experiences while making use of these tools, revealing the need to more fitly assist these professionals with more academic and professional support contextually applied to their realities.
Multiletramentos críticos: revivendo a construção de sentidos à luz de uma concepção bakhtiniana de linguagem
Authors: Tilio Rogerio , Schlude Victor
Published: June 2022

Publicado em 1996 por 10 pesquisadores de diferentes áreas e instituições, o manifesto que apresenta a pedagogia dos multiletramentos é uma reconhecida proposta de ensino que pretende abarcar diferentes práticas e saberes da contemporaneidade (THE NEW LONDON GROUP, 1996). No Brasil, a pedagogia dos multiletramentos é bem recebida e disseminada, integrando até mesmo os componentes curriculares da BNCC e subsidiando explicitamente pelo menos uma coleção didática para o ensino de Inglês aprovada pelo PNLD (TILIO, 2016). Partindo de reflexões sobre a pedagogia dos multiletramentos (ROJO, 2012; 2013; TILIO, 2015; 2017), pretendemos revisitar os aspectos do “como” desse fazer pedagógico. Nesse movimento, integramos uma concepção socioideológica da linguagem (VOLOCHÍNOV, 1929)) a essa pedagogia. Especialmente no que tange ao esforço de pensar uma pedagogia que possa formar cidadãos globais críticos, investimos no diálogo da concepção bakhtiniana de linguagem com os multiletramentos a fim de promover um trabalho pedagógico que permita um olhar essencialmente social para os sentidos. Após essa discussão, apresentaremos uma atividade para ensino de língua inglesa dentro dessa proposta. Visamos, com a análise dessa proposta pedagógica, exemplificar nossa discussão teórica. Nesse sentido, defendemos que a pedagogia dos multiletramentos seja orientada por práticas críticas de ensino, em especial por meio de uma concepção bakhtiniana de linguagem.
Teatro: Possibilidade de Desenvolvimento de Agência em Atividades organizadas pela linguagem da Argumentação Colaborativa
Authors: Mota-Salvador Francisca Nunes , Magalhães Maria Cecília Camargo
Published: June 2022

Este artigo discute a argumentação colaborativa na organização da linguagem, em um projeto de teatro, voltado ao desenvolvimento de novos modos de agir (agência), em um sistema de atividades em cadeia (LIBERALI) que se propõe criativa. Trata-se de um recorte da dissertação de mestrado, desenvolvida com alunos do 7º. ano do Ensino Fundamental, “Teatro como Possibilidade de Desenvolvimento de Agência” (MOTA-SALVADOR, 2014), defendida na PUC-SP. Está inserido no contexto da Linguística Aplicada Crítica, apoiado na Teoria da Atividade Sócio-Histórico-Cultural (TASHC), na linguagem da argumentação colaborativa como organização central para o desenvolvimento de relações dialógicas em contextos educacionais. Teórico-metodologicamente está organizado com base na abordagem da Pesquisa Crítica de Colaboração (MAGALHÃES, 2010; 2011; 2018), cujo objetivo é criar contextos de negociação na construção de conhecimento novo e ações críticas no agir com outros. Os dados são um recorte de um dos Elos de uma Cadeia Criativa, analisados com base nas discussões da linguagem da argumentação colaborativa (LIBERALI, 2011; 2013). Os resultados mostram a relevância da organização da linguagem pela argumentação colaborativa nas interações, para todos os participantes e sua importância ao agir intencional e responsivo na construção de relações que possibilitem desenvolvimento cultural, em contextos multissemióticos.
Deus acima de todos
Authors: Barros Júnior Paulo Sérgio Ferreira
Published: June 2022

O presente artigo tem como tema “Deus acima de todos: Bolsonaro, evangélicos e voto nas eleições presidenciais de 2018 no Brasil”. Por meio de uma revisão bibliográfica, analisa-se como o segmento protestante/evangélico foi fundamental para a eleição de Jair Bolsonaro em 2018. Neste sentido, traça-se uma linha do tempo na qual ressalta-se como a religião influenciou a política brasileira desde o período colonial até os dias atuais, verifica-se como os protestantes inseriram-se na política ao longo da história Brasil e como passaram a buscar influenciá-la com base nos seus princípios religiosos que, via de regra, são relacionados a elementos do conservadorismo comportamental. Esse fator, como analisado no decorrer do texto, foi fundamental para que Bolsonaro conquistasse o apoio da maioria dos evangélicos em 2018. Para a análise do tema, selecionamos autores como Gedeon Alencar (2020), David Mesquiati (2020), Jairo Nicolau (2020), Ricardo Alexandre (2020) e Yago Martins (2020). Vale ressaltar que não se objetiva esgotar o tema, todavia, considera-se que o discurso religioso foi um fator importante para o resultado das eleições de 2018 no Brasil.
estudo interdisciplinar de geografia e religião
Authors: Tweed Thomas A. , Cruz Eduardo Rodrigues
Published: June 2022

Estudiosos em cada campo possuem pressuposições, incluindo noções sobre a natureza da verdade e do status da teoria, assim, partindo de minha própria teoria espacial da religião, comecei a questionar qual matriz filosófica parece ser mais promissora para o estudo interdisciplinar da geografia e religião. Defendo que o pragmatismo, especialmente aquele expresso nos últimos escritos do filósofo Hilary Putnam, pode ser útil para responder algumas das mais incomodas questões epistemológicas. Para evidenciar a utilidade de minha teoria, e sua perspectiva pragmática em questões fundamentais sobre sentido, verdade e interpretação, arremato considerando suas implicações para o estudo interdisciplinar da geografia e religião, bem como identifico alguns princípios teóricos norteadores.
Quantifying uncertainty of a mathematical model of drug transport in tumors
Authors:   Ibn Zohr University, Department of Science Computing, Essarrout S. , Mahani Z. ,   Ibn Zohr University, Department of Science Computing, Raghay S. ,   Cadi Ayyad University, Department of Mathematics
Published: June 2022

This paper presents a numerical simulation in the two-dimensional for a system of PDE governing drug transport in tumors with random coefficients, which is described as a random field. The continuous stochastic field is approximated by a finite number of random variables via the Karhunen–Loève expansion and transform the stochastic problem into a determinate one with a parameter in high dimension. Then we apply a finite difference scheme and the Euler–Maruyama Integrator in time. The Monte Carlo method is used to compute corresponding simple averages. We compute the error estimate using the Central Limits Theorem (CLT) and the error estimate for the finite difference method. Some numerical results are simulated to illustrate the theoretical analysis. We also propose a comparison between the stochastic and determinate solving processes of our system where we show the efficiency of our adopted method.
Dynamical analysis of an HCV model with cell-to-cell transmission and cure rate in the presence of adaptive immunity
Authors:   Laboratory of Mathematics, Computer Science and Applications, FST Mohammedia, University Hassan II of Casablanca, Sadki M. , Harroudi S. ,   ENCG of Casablanca, University Hassan II, Allali K. ,   Laboratory of Mathematics, Computer Science and Applications, FST Mohammedia, University Hassan II of Casablanca
Published: June 2022

In this paper, we will study mathematically and numerically the dynamics of the hepatitis C virus disease with the consideration of two fundamental modes of transmission of the infection, namely virus-to-cell and cell-to-cell. In our model, we will take into account the role of cure rate of the infected cells and the effect of the adaptive immunity. The model consists of five nonlinear differential equations, describing the interaction between the uninfected cells, the infected cells, the hepatitis C virions and the adaptive immunity. This immunity will be represented by the humoral and cellular immune responses. This work begins with proving the non-negativity and the boundedness of solutions and determining the basic reproduction number. Secondly, five equilibria are established, the local stability analysis for all the equilibria is demonstrated theoretically and numerically. Finally, we have concluded that the numerical results are coherent with our theoretical postulations.
Pelaksanaan Kampanye Pemilihan Gubernur Sumatera Barat Berdasarkan PKPU Nomor 13 Tahun 2020
Authors: Putri Devika , Eka Putri Nora
Published: June 2022

This study aims to determine the implementation of the West Sumatra Governor Election Campaign based on PKPU Number 13 of 2020. The existence of the Covid-19 pandemic makes the 2020 Campaign Implementation must comply with the health protocols as stipulated in PKPU Number 13 of 2020. The type of research is qualitative research with descriptive methods. Informants were selected using a purposive sampling technique, namely the selection of informants based on certain characteristics according to the research objectives. Data collection is carried out by interviewing related to the problems studied, then documentation studies which are supporting data and relevant to the problems studied in the form of reports, legislation, pictures and other supporting data. The technique of testing the validity of the data uses the triangulation method. While the data analysis technique is done by reducing the data, presenting the data, and drawing conclusions. The results showed that the Implementation of the 2020 West Sumatra Governor Election Campaign had been carried out in accordance with the rules contained in PKPU Number 13 of 2020 although there were still violations committed by the 2020 West Sumatra Governor Candidate Pair. And the factors that influenced the campaign were the campaigners, campaign messages, campaign media, and campaign target audiences
Strategi Dinas Tenaga Kerja dan Transmigrasi Kabupaten Bengkalis dalam Mengurangi Pengangguran di Kota Duri
Authors: Mardiah Ainun , Alfiyati Rizma , Sehani Sehani
Published: June 2022

This research was conducted at the Department of Manpower and Transmigration of Bengkalis Regency. This study aims to analyze the strategy of the Manpower and Transmigration Office of Bengkalis Regency in reducing unemployment in Duri City and to find out what are the obstacles to the Bengkalis Regency Manpower and Transmigration Office in reducing unemployment in Duri City. The research method used descriptive qualitative by using several data collection techniques, namely interviews with research informants, observation and also documentation. The results of the study revealed that the strategy of the Bengkalis Regency Manpower and Transmigration Office in carrying out the strategy program was assessed from the previous year as being maximal, except that in 2020 it was not maximized. It can be seen from the unemployment data which is still increasing in 2020. The obstacles to implementing the strategy in reducing the unemployment rate in this city of thorns are the limited budget and there are still many non-functional human resources.
Soutien aux travailleurs de la santé et détresse psychologique : réflexion sur la situation actuelle et la période suivant la pandémie de COVID-19
Authors: Styra Rima , Hawryluck Laura , McGeer Allison , Dimas Michelle , Lam Eileen , Giacobbe Peter , Lorello Gianni , Dattani Neil , Sheen Jack , Rac Valeria E. , Francis Troy , Wu Peter E. , Luk Wing-Si , Nadarajah Jeya , Gold Wayne L.
Published: June 2022

Introduction

Cette étude explore la relation entre le soutien émotionnel, le risque perçu et les résultats en matière de santé mentale chez les travailleurs de la santé, qui font face à des taux élevés d’épuisement professionnel et de détresse mentale depuis le début de la pandémie de COVID-19.

Méthodologie

Une enquête transversale a été menée en ligne au cours de la première vague de la pandémie de COVID-19 auprès de travailleurs de la santé de divers centres de la région du Grand Toronto (Ontario, Canada) pour évaluer les stratégies d’adaptation, la confiance dans les mesures de lutte contre les infections, l’impact du travail antérieur lors de l’épidémie de SRAS survenue en 2003 et le soutien émotionnel. Les résultats en matière de santé mentale ont été évalués au moyen de l’échelle du trouble d’anxiété généralisée (GAD-7), de l’échelle d’impact des événements – révisée (IES-R) et du questionnaire sur la santé des patients (PHQ-9).

Résultats

Sur les 3 852 participants, 8,2 % ont eu recours à des services professionnels en santé mentale, 77,3 % ont reçu du soutien émotionnel de la part de membres de leur famille, 74,0 % de la part d’amis et 70,3 % de la part de collègues. Les personnes qui ne se sont pas senties soutenues dans leur travail présentaient des probabilités plus élevées d’éprouver des symptômes d’anxiété modérés et sévères (rapport de cotes [RC] = 2,23; intervalle de confiance [IC] à 95 % : 1,84 à 2,69), de trouble de stress post-traumatique (TSPT) (RC = 1,88; IC à 95 % : 1,58 à 2,25) et de dépression (RC = 1,88; IC à 95 % : 1,57 à 2,25). Près de 40 % avaient peur de parler à leur famille des risques auxquels ils étaient exposés au travail. Ceux qui ont pu partager cette information faisaient état d’un risque plus faible d’anxiété (RC = 0,58; IC à 95 % : 0,48 à 0,69), de TSPT (RC = 0,48; IC à 95 % : 0,41 à 0,56) et de dépression (RC = 0,55; IC à 95 % : 0,47 à 0,65).

Conclusion

Les sources informelles de soutien, en particulier la famille, les amis et les collègues, jouent un rôle important dans l’atténuation de la détresse et devraient être encouragées et utilisées davantage par les travailleurs de la santé.
The mental health experience of treatment-seeking military members and public safety personnel: a qualitative investigation of trauma and non-trauma-related concerns
Authors: Easterbrook Bethany , Brown Andrea , Millman Heather , Van Blyderveen Sherry , Lanius Ruth , Heber Alex , McKinnon Margaret , O’Connor Charlene
Published: June 2022

Introduction

Paramedics, firefighters, police officers and other public safety personnel (PSP) as well as Canadian Armed Forces (CAF) members are frequently exposed to stressors and demanding work environments. Although their specific work-related tasks may vary, a commonality between these occupations is the significant likelihood of repeated exposure to potentially psychologically traumatic events (PPTE) over the course of their careers. Due in part to these repeated exposures, CAF members and PSP are at an elevated risk of mental health concerns including posttraumatic stress disorder. The purpose of this study was to obtain a more in-depth understanding of the trauma- and non-trauma-related experiences of active or retired PSP and CAF members that may be implicated in mental health issues and resultant treatment and recovery.

Methods

Study participants were recruited during inpatient treatment at a private mental health and addictions inpatient hospital in Canada. We conducted and audiotaped semistructured focus groups and transcribed the discussions. Interpretive phenomenological analysis and thematic coding generated a coding scheme from which to identify concepts and linkages in the data.

Results

Analysis generated four primary themes: interpersonal relationships, personal identity, mental health toll and potential moral injury. A variety of subthemes were identified, including family dynamics, inability to trust, feelings of professional/personal betrayal, stigma within the CAF/PSP culture, increased negative emotions about self/others, and a reliance on comradery within the service.

Conclusion

The information gathered is critical to understanding the perspectives of PSP and military members as the career stressors and related exposure to PPTE of these occupations are unique.
The practice of ontogenetically determined movements of standing up among children and adolescents at the Department of Hematopoietic Stem Cell Transplantation as a preventive measure for orthostatic hypotension
Authors: Zhukov M. Yu. , Mitrakov N. N. , Laysheva O. A.
Published: June 2022

Hematopoietic stem cell transplantation (HSCT) requires a long hospitalization during which patients have to stay in transplantation wards, mainly in their single isolation rooms. One of the main goals of rehabilitation for HSCT patients is to prevent physical activity deficit by the introduction of an appropriate exercise programme and the monitoring of exercise adherence. The aim of our study was to evaluate the effectiveness of the prescribed exercise programme based on basic locomotor patterns to prevent physical activity deficit. The interim results of the prospective randomized controlled study included data from 20 patients. The study was approved by the Independent Ethics Committee and the Scientific Council of the 1Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation. An experimental group included 11 patients aged 8–16 years old (the median age was 12 years old); a control group included 9 patients aged 5–11 years old (the median age was 8 years old). Patients from the experimental group were preliminarily taught a set of exercises aimed at practicing ontogenically determined standing up which they should further perform during a day in their isolation rooms. The control group patients received recommendations on how to maintain physical activity in their isolation rooms. Their physical activity during a day was then monitored by the researchers. All study subjects underwent an orthoclinostatic test (i.e., transition from lying to standing and back) for the evaluation of the autonomic nervous system function on Day 1 of pre-transplant conditioning therapy and at the time of discharge from the HSCT Department. During the entire stay at the HSCT Department, the patients from both groups were daily assessed using the ADL (activities of daily living) scale. At the time of discharge from the HSCT Department, the experimental group patients showed more adaptive autonomic nervous system responses than the control group patients. Our interim analysis showed that the patients from the experimental group had higher scores of activities of daily living than the control patients. Orthoclinostatic test results confirmed that patients undergoing HSCT for acute leukemia were predisposed to develop maladaptive conditions or even orthostatic hypotension. A set of exercises including those for the training of ontogenetically determined process of standing up was shown to be an effective tool for the prevention of insufficient autonomic nervous system responses. Even a short (30 min) face-to-face session with a physical therapist significantly increased a patient's daily physical activity.
The first results of genetic screening and exploration of genotype-phenotype correlations in retinoblastoma patients from Belarus
Authors: Guryanova I. E. , Liubushkin A. V. , Makarevich O. O. , Litvinova D. Yu. , Vertеlko V. R. , Valochnik A. V. , Polyakova E. A. , Migas A. A. , Konoplya N. E.
Published: June 2022

Retinoblastoma is an aggressive eye tumor originating from maturing cone precursors in the developing retina and most commonly seen in childhood. In 98 % of patients, retinoblastoma is caused by bi-allelic inactivation of the RB1 tumor suppressor gene. Approximately 40 % of disorders in the RB1 gene are germline.

   This study aimed to analyze the frequency of germline RB1 variants in a cohort of Belarusian patients with retinoblastoma and to correlate the variants with clinical phenotypes. The study was approved by an Independent Ethics Committee and the Scientific Council of the Belarusian Research Center for Pediatric Oncology, Hematology and Immunology. The study included 20 patients from unrelated families (9 patients with unilateral retinoblastoma, 11 – with bilateral). Two out of eleven patients with bilateral retinoblastoma had a positive family history. Genomic DNA was extracted from peripheral blood mononuclear cells. Using polymerase chain reaction, we obtained fragments including sequences of all exons, regions of splice sites and promoter regions of the RB1 gene. Nucleotide sequences of the obtained amplicons were detected by next-generation sequencing. All clinically significant variants were confirmed by Sanger sequencing. Multiplex ligation-dependent probe amplification (MLPA) or fluorescence in situ hybridization (FISH) were used to detect gross alterations. A genetic analysis of blood relatives was carried out for five probands with detected germline variants. We identified 13 different variants in 14 patients: 38.5 % (n = 5) of them were defects in splice sites; 15.4 % (n = 2) – missense mutations; 15.4 % (n = 2) – small deletions (frameshift); 23% (n = 3) – large deletions; 7.7% (n = 1) – nonsense mutations. Four of these variants had not been previously reported in patients with retinoblastoma from other populations (exon 3: c.350_351delTT, p. Phe117TyrfsTer2; exon 8: c.861+2T>G; exon 24: c.2520+4A>G; Del of exons 16, 17). Germline mutations were detected in 33.3 % (3/9) of patients with unilateral retinoblastoma and in 100% (11/11) of patients with bilateral disease. A genetic screening of relatives showed that three variants were de novo, and two variants were inherited from parents in families with a positive history of retinoblastoma. Here we reported the first results of genetic examination of Belarusian patients with retinoblastoma. Seventy-eight point six per cent (78.6 %) of variants were detected by sequencing, 21.4 % were identified with the help of the MLPA and FISH methods. Among sporadic cases, germline RB1 variants were detected in 66.6 % (12/18) of cases. A full range of screening techniques is required to achieve high sensitivity of detection in retinoblastoma patients. Our study also provides new evidence that will inform patient management and genetic counseling.
Integración del movimiento en el último curso de Educación Infantil: los espacios compartidos
Authors: Nielsen-Rodríguez Adriana , Romance-García Ramón
Published: June 2022

Esta investigación tiene como objetivo analizar los espacios compartidos, una práctica innovadora en Educación Infantil relacionada con la integración del movimiento en los contenidos académicos, así como su influencia en el aprendizaje y en la cantidad de actividad física desarrollada por el alumnado. En el estudio participaron 25 estudiantes (15 niños y 10 niñas) de 5 años de un centro educativo de la provincia de Málaga. La investigación adopta una perspectiva analítico-descriptiva, utilizando el estudio de caso junto con otros métodos de recogida y análisis de la información. Los resultados evidencian la necesidad e importancia de implementar metodologías activas como los espacios compartidos que incrementen la cantidad de actividad física del alumnado, así como los beneficios que aporta al desarrollo físico, cognitivo, social y a los procesos de enseñanza-aprendizaje, que se vuelven más activos y significativos.
Pre-shape calculus and its application to mesh quality optimization
Authors: Luft Daniel , Schulz Volker
Published: June 2022

Deformations of the computational mesh, arising from optimization routines, usually lead to decrease of mesh quality or even destruction of the mesh. We propose a theoretical framework using pre-shapes to generalize the classical shape optimization and calculus. We define pre-shape derivatives and derive corresponding structure and calculus theorems. In particular, tangential directions are featured in pre-shape derivatives, in contrast to classical shape derivatives, featuring only normal directions. Techniques from classical shape optimization and calculus are shown to carry over to this framework. An optimization problem class for mesh quality is introduced, which is solvable with the use of pre-shape derivatives. This class allows for simultaneous optimization of the classical shape objectives and mesh quality without deteriorating the classical shape optimization solution. The new techniques are implemented and numerically tested for 2D and 3D.
Learning causal theories with non-reversible MCMC methods
Authors: Krajewska Antonina
Published: June 2022

Causal laws are defined in terms of concepts and the causal relations between them. Following Kemp et al. (2010), we investigate the performance of the hierarchical Bayesian model, in which causal systems are represented by directed acyclic graphs (DAGs) with nodes divided into distinct categories. This paper presents two non-reversible search and score algorithms (Q
1 and Q
2) and their application to the causal learning system. The algorithms run through the pairs of class-assignment vectors and graph structures and choose the one which maximizes the probability of given observations. The model discovers latent classes in relational data and the number of these classes and predicts relations between objects belonging to them. We evaluate its performance on prediction tasks from the behavioural experiment about human cognition. Within the discussed approach, we solve a simplified prediction problem when object classification is known in advance. Finally, we describe the experimental procedure allowing in-depth analysis of the efficiency and scalability of both search and score algorithms.
Quantum-inspired method of neural modeling of the day-ahead market of the Polish electricity exchange
Authors: Tchórzewsk Jerzy , Ruciński Dariusz
Published: June 2022

The paper presents selected elements of a modelling methodology involving quantization, quantum calculations and dequantization on the example of the neural model of the Day-Ahead Market of the Polish Electricity Exchange. Based on the fundamental assumptions of quantum computing, a new method has been proposed here of converting the real numbers in decimal notation into quantum mixed numbers using the probability modules of quantum mixed number and the principle of superposition, along with a new method of quantum calculations using linear algebra and vectormatrix calculus, and the Artificial Neural Network was taught accordingly. Dequantization of quantum mixed numbers to real numbers in decimal notation using the new method of dequantization has been proposed as well. The operation of the methods introduced was shown on numerical examples.
Voting and MCDM: the pedagogy of the Saari triangle
Authors: Hakula Jaakko
Published: June 2022

The essay has a twofold objective: primarily, to present an application of voting theory as a possible evaluation method, and concurrently, to offer a pedagogic framework, based on that very application. Evaluation and certain notions of preference and value have common semantic roots. By equating preference and choice, we end up amidst social choice (SC) theory and voting methods, also manageable as joint decisions in multiple-criteria decision making (MCDM). With the aid of the Saari triangle some essential differences of pairwise and positional voting rules for up to three alternatives can be depicted. A voting or decision rule does not necessarily follow the true preferences of the actors, but may mirror the problematics of the chosen rule. The Saari triangle makes it possible to visualize some paradoxical results in the exemplary evaluations of digital websites through an imaginary case description via voting and MCDM. As candidates and voters in SC are put to stand for alternatives and criteria in MCDM, the methodological and pedagogical goals of the study are achieved.
On the use of data analysis and OR modelling in MCDM problems: a case analysis – a rejoinder to the paper by Sousa Ribeiro et al
Authors: Owsiński Jan W.
Published: June 2022

Taking as an example the very interesting and motivating paper by Sousa Ribeiro et al. (2021) an attempt is made of providing a couple of insights into the decision making process from the point of view of the potentially helpful aspects of data analysis and OR-related modelling. These are just hints and suggestions, meant primarily to emphasise the multifaceted character of the decision making situations and processes, especially when concerning more complex issues. While the course of the procedure proposed and exemplified in Sousa Ribeiro et al. (2021) is treated as fully correctly and successfully carried out to the end, we wish to show the potential use of information, constituting in a sense a “by-product” of such a procedure, or, actually, of any similar procedure, aimed at supporting decision making.
Morphometric and Genetic Characterization of Honey Bees (Apis mellifera L.) From Thrace Region of Turkey
Authors: Özdil Fulya , Oskay Devrim , Işık Raziye , Yatkın Selen , Aydın Abdurrahman , Güler Ahmet
Published: June 2022

A detailed morphological and genetic characterization of honey bees from the Thrace and west Anatolian regions of Turkey was surveyed. A total of 1650 worker bee samples (110 colonies) were evaluated with the forty-one morphological characters and 217 honey bee samples were analyzed via DNA sequencing of the tRNAleu-cox2 region. In this study, three different populations, Thrace (Tekirdağ, Kırklareli and Edirne provinces), Island Gökçeada, and western Anatolia were formed based on morphometrics, since the Marmara Sea has taken a very strong barrier role in this formation. The morphological similarity of the Thrace population was supported by the genetic analysis. The sequencing of the tRNAleu-cox2 region revealed twenty-two different haplotypes, sixteen of which are novel. The C2d, macedonica-like haplotype, was the most widely found haplotype (48%) all around the Thrace region. Along with the C2d haplotype, previously published C2s, C2v, C2i, C2j, and C2h haplotypes, and the newly found haplotypes were also observed but less frequently. In this study, Thrace honey bees were found to more similar to A. m. macedonica through the mtDNA sequence analysis, whereas carnica-like honey bees were only found near the Istranca mountain ridges, Kırklareli province and macedonica-like honey bees all around the Thrace region. According to our results, some of the Thrace honey bee populations may be both A. m. carnica and A. m. macedonica but the assignment to the latter subspecies seems more likely due to its geographic range.
Logistics Strategy Research for Efficient Operation of Airports and Ports
Authors: Yoon Donghun
Published: June 2022

The competition between airports and ports is intensifying, and countries are actively implementing and promoting policies to strengthen their competitiveness and role of a logistics hubs. Airports and ports play a key role in national competitiveness because they serve as logistics platforms for air transport and sea transport. Major countries are improving airports and ports as part of the competitive struggle and actively pursuing policies to gain a competitive advantage as logistics platforms and hubs. In order to improve efficiency, it is essential to develop a logistics strategy. In this study, we analyse the changes in transport volume in major airports and ports in South Korea, China, and Hong Kong, and assess South Korea’s logistics strategy and competitiveness. We present and discuss studies on the importance of logistics strategies for efficient operation of airports and ports.
Does 12-Week Aerobics Training Influence Body Composition in Middle-Aged Women?
Authors: Małgorzata Charmas , Dorota Różańska
Published: June 2022

Introduction. It is very important to determine body composition, as it plays a significant role in the formation of many vital functions of the human. The purpose of this research was to assess the effect of 12-week aerobics training on body composition in middle-aged women.

Material and methods. Thirteen women aged 35-50 who did not practice any sport actively took part in 12-week aerobics training. Body weight and height were measured, body mass index (BMI) and waist/hip ratio (WHR) were calculated. Body composition parameters: total body water (TBW), extracellular water (ECW) and intracellular water (ICW), fat mass (FM), free fat mass (FFM) muscle mass (MM), and basal metabolic rate (BMR) were measured using BIA method.

Results. The 12-week aerobics training elicited increases in ICW, FFM, MM, and BMR and a decrease in hip circumference. Twelve weeks without exercise (control group, n = 10) caused an increase in body mass, BMI and hip circumference. No statistically significant changes were recorded in body composition parameters in the control group.

Conclusions. The lack of any physical activity shows that the maintenance of that status can cause overweight followed by obesity.
The effect of low dose teophillyne on the improvement of copd assessment test score, interleukin-8 level and sputum neutrophil count in patients with stable COPD
Authors: Sutanto Yusup Subagio , Sutanto Magdalena - , Kurniawan Hendra -
Published: June 2022

Background: Harmful particles from cigarette smoke induces an inflammatory immune response in the lungs, followed by the release of proinflammatory cytokines such as TNF-α and IL-8 and damages histone deacetylase 2 (HDAC2) in the cell core leading to glucocorticoid resistance in COPD.  Low dose Theophylline of below 10mg/L has an anti-inflammatory effect by activating HDAC.  This study aimed to analyze the effect of low dose theophylline on the clinical improvement of stable COPD patients assessed by the COPD Assessment Test (CAT) score, IL-8 level, and sputum neutrophil count.Methods: We conducted a quasi-experimental clinical study using a pre-post test in stable COPD patients visiting the Pulmonary Outpatient Clinic of  DR. Moewardi hospital Surakarta, between July and September 2016.  The samples were taken using a consecutive sampling technique, assigned into two groups, treatment, receiving standard therapy plus 70 mg low dose theophylline per 8 hours, and control receiving standard therapy only.  CAT score, IL-8 level, and sputum neutrophil count were measured at baseline and four weeks after treatment.Results: The treatment group's CAT score decreased by 3.67±3.58 pg/ml and increased by 2.40±3.38 pg/ml in the control group (p=0.003).  IL-8 level decreased by 4.31±13.06 pg/ml in the treatment group and increased by 0.88±13.89 pg/ml in the control group (p=0.116).  The sputum neutrophil count decreased in both treatment and control groups by 4.00 ±40.33 pg/ml and 2. 87±39. 91 pg/ml (p=0.939).Conclusion: Statistically low dose theophylline significantly lowers the CAT score of stable COPD patients. It also decreases IL-8 level and sputum neutrophil count, although it is not significant.
Etika batuk pada masa pandemic COVID-19
Authors: Saminan Saminan
Published: June 2022

Astrak. Batuk merupakan gejala penyakit yang paling umum di jumpai baik pada anak maupun pada orang dewasa, batuk menjadi salah satu gejala penyakit saluran napas disamping sesak, mengi dan sakit dada. Pada saat batuk, benda asing (sekret) dalam saluran pernapasan terbawa keluar oleh udara ekpirasi sehingga paru tetap dalam keadaan bersih. Etika batuk dapat mengurangi penyebaran sekret saluran pernapasan yang mengandung partikel infeksius. Gejala paling umum yang terlihat akibat COVID-19 yaitu batuk, demam, sesak napas, kelelahan dan diare yang disebabkan pernah kontak dengan orang yang sudah terinfeksi COVID-19, bila sudah positif maka organ yang paling mudah terganggu adalah paru-paru. Kata Kunci : Etika Batuk, Covid-19, Pandemi ABSTRACT. Coughing is the most common symptom of disease in both children and adults, coughing is a symptom of respiratory disease besides tightness, wheezing and chest pain. When coughing, foreign objects (secretions) in the respiratory tract are carried out by the expiratory air so that the lungs remain clean. Cough etiquette can reduce the spread of respiratory secretions containing infectious particles. The most common symptoms seen due to COVID-19 are coughing, fever, shortness of breath, fatigue and diarrhea caused by having contact with people who have been infected with COVID-19, if they are positive, the organs that are most easily disturbed are the lungs.  Keyword : Cough, Covid-19, Pandemic
Invasive Dermatophytosis in HIV/AIDS Patient by Zoophilic Trichophyton verrucosum
Authors: Mahdani Wilda -
Published: June 2022

Invasive dermatophytosis is a dermatophyte infection characterized by fungal invasion into deeper skin tissue including the dermis and subcutaneous areas. Herein, a man who was an HIV/AIDS sufferer was reported to develop an unusually invasive dermatophytosis in the form of nodules and ulceration. His CD4+ cells count was 88 cells/µl with a percentage of 1.87%. Self-medication with topical antibiotics did not respond. Microbiological examination was carried out including direct potassium hydroxide preparation and fungal culture. The etiologic diagnosis of invasive dermatophytosis by Trichophyton verrucosum  was established. This is one of the zoophilic fungus that causes ringworm in cattle. It was suspected that the patient was inoculated due to contact with fomites containing fungi while working as a construction worker. Dermatophytes can cause atypical infections with a completely unexpected appearance in immunocompromised patients. The diagnosis is largely determined by a high level of clinical suspicion followed by microbiological examination.