bluuebunny/crossref_metadata_2025 huggingface dataset:
The impact of radiation caries on morbidity and mortality outcomes of head and neck squamous cell carcinoma patients
Authors: Palmier Natália Rangel , Prado‐Ribeiro Ana Carolina , Mariz Bruno Augusto Linhares Almeida , Rodrigues‐Oliveira Letícia , Paglioni Mariana de Pauli , Napimoga Juliana Trindade Clemente , Pedroso Caique Mariano , Morais‐Faria Karina , Oliveira Maria Cecília Querido de , Vechiato‐Filho Aljomar José , Brandão Thaís Bianca , Santos‐Silva Alan Roger
Published: March 2023

Aims

Radiation caries (RC) is a highly prevalent and chronic complication of head and neck radiotherapy (HNRT) and presents a challenge for clinicians and patients. The present study aimed to assess the impact of RC on the morbidity and mortality outcomes of head and neck squamous cell carcinoma (HNSCC) patients.

Methods and Results

Patients were divided into three groups: (1) RC (n = 20), (2) control (n = 20), and (3) edentulous (n = 20). Information regarding the number of appointments, dental procedures, osteoradionecrosis (ORN), prescriptions, and hospital admissions were collected. Mortality outcomes were assessed through disease‐free survival (DFS) and overall survival (OS) rates. RC patients required more dental appointments (p < .001), restorations (p < .001), extractions (p = .001), and antibiotic and analgesic prescriptions (p < .001). Kaplan–Meier subgroup analyses showed a significantly increased risk of ORN in RC compared to edentulous patients (p = .015). RC patients presented lower DFS rates (43.2 months) than the control and edentulous groups (55.4 and 56.1 months, respectively).

Conclusions

RC impacts morbidity outcomes among cancer survivors due to increased demand for medication prescriptions, multiple specialized dental appointments, invasive surgical treatments, increased risk of ORN, and increased need for hospital admissions.
Constrained ‘choices’: Optional familism and educational divides in work‐family arrangements
Authors: Jozwiak Andreas
Published: March 2023

German family policy was dramatically reformed in the 2000s because of dual reforms to parental leave and childcare provision. While considerable evidence has suggested the reforms affected employment and other outcomes, this article asks what the consequences of these reforms are for the family, specifically for patterns of work‐family arrangements. Moreover, it asks how education matters for work‐family arrangements post‐reform. Using German Socio‐Economic Panel data, I show that college‐educated mothers giving birth to their first child after the reforms earned roughly half of household income if they benefited from expanded local childcare access. By contrast, in areas with lower childcare availability, even among the college‐educated, mothers' earnings resemble pre‐reform patterns, where mothers earn between a quarter to a third of household income. Therefore, the reforms contributed to greater differences in family structures based on the education. One interpretation of these findings is that the status reproducing nature of the Continental welfare states has recalibrated for the modern age, de‐gendered for those with the greatest labour market returns.
Integrative approach resolves the systematics of barred wolf snakes in the Lycodon striatus complex (Reptilia, Colubridae)
Authors: Amarasinghe Amarasinghe A. Thasun , Masroor Rafaqat , Lalremsanga Hmar T. , Weerakkody Sanjaya , Ananjeva Natalia B. , Campbell Patrick D. , Kennedy‐Gold Stevie R. , Bandara Sanjaya K. , Bragin Andrey M. , Gayan Atthanagoda K. A. , Sharma Vivek R. , Sayyed Amit , Biakzuala Lal , Kanishka Andradige S. , Ganesh Sumaithangi R. , Ineich Ivan , de Silva Anslem , Wickramasinghe Lakshman J. M. , Seneviratne Sampath S. , Poyarkov Nikolay A. , Vogel Gernot , Jablonski Daniel
Published: March 2023

We reviewed the systematics of Lycodon striatus (Shaw, 1802), including all available name‐bearing types of its synonyms after evaluating phylogeographic (genetics), morphological (morphometry, meristic, and hemipenes), osteological and distribution evidence. Lycodon striatus sensu lato is widely distributed throughout South and Central Asia and mimics elapids. Based on phylogenetic analyses of mitochondrial DNA, we demonstrate that populations from (i) eastern and central Peninsular India plus Sri Lanka and (ii) south‐western parts of Central Asia form two different clades representing two distinct species: L. striatus sensu stricto and L. bicolor comb. nov. respectively. These two clades are sisters to L. deccanensis (in the case of L. striatus) and L. jara (in the case of L. bicolor) and together form two main sister radiations. Although the external morphological variability is high in both species, the genetic variability is higher only in L. striatus but not distinct enough to represent more than one species if using the phylogenetic or biological species concept. The phylogeny of the L. aulicus group hints at Sri Lankan L. striatus, likely having evolved in continental Asia through a probable overland dispersal across the Bay of Bengal (present Palk Strait) into Sri Lanka. This dispersal may have been facilitated by low sea levels during the Pleistocene glaciations when Sri Lanka was connected to mainland India. After considering genetic divergence (with a p‐distance of 1.8%–2.1% in the mitochondrial cytochrome b gene) and morphological evidence, we synonymize the Sri Lankan subspecies, L. s. sinhaleyus Deraniyagala, 1955, with L. striatus sensu stricto. The eastern and central Indian L. striatus (i.e. L. striatus sensu stricto) is morphologically distinct and deeply divergent genetically compared to Tajik and Pakistani L. bicolor with a p‐distance of 13.6% in cytochrome b gene (mtDNA). Interestingly, L. bicolor is conspecific (p‐distance 1.4%) with L. mackinnoni, a western Himalayan endemic, and it reveals intraspecific clinal variation.
Strongly invertible knots, equivariant slice genera, and an equivariant algebraic concordance group
Authors: Miller Allison N. , Powell Mark
Published: March 2023

We use the Blanchfield form to obtain a lower bound on the equivariant slice genus of a strongly invertible knot. For our main application, let be a strongly invertible genus one slice knot with nontrivial Alexander polynomial. We show that the equivariant slice genus of an equivariant connected sum is at least . We also formulate an equivariant algebraic concordance group, and show that the kernel of the forgetful map to the classical algebraic concordance group is infinite rank.
Equivalent Beam Model and Improved Structure Design of Large Space Antenna Truss With Geometric Nonlinearity
Authors: Jiang Shi , Guo-Ping Cai
Published: March 2023

This paper proposes a extend linear equivalent method that can extend the linear equivalent micropolar beam model to the nonlinear equivalent micropolar beam model to analyze nonlinear vibration for large space truss structure, and also proposes a lattice enhancement method to improve the cantilever truss for the buckling problem that exists in space cantilever truss structures. The nonlinear equivalent model is obtained by introducing a corotating coordinate system into the linear equivalent beam model. Since the instability of the fixed root end of the cantilever truss is the main reason for buckling, the method of strengthening the longeron of the truss lattice by lattice is proposed. The accuracy of the equivalent geometric nonlinear model and the effectiveness of the improved cantilever truss structure are verified by four numerical simulation examples. The methods proposed in this paper provide some reference for studying the dynamics analysis of large space trusses and the design of structures.
Workflow Comparison for Combined 4D MRI/CFD Patient-Specific Cardiovascular Flow Simulations of the Thoracic Aorta
Authors: Tajeddini Farshad , Romero David A. , McClarty Davis , Chung Jennifer , Amon Cristina H.
Published: March 2023

Computational fluid dynamics (CFD) has been widely used to predict and understand cardiovascular flows. However, the accuracy of CFD predictions depends on faithful reconstruction of patient vascular anatomy and accurate patient-specific inlet and outlet boundary conditions. 4-Dimensional magnetic resonance imaging (4D MRI) can provide patient-specific data to obtain the required geometry and time-dependent flow boundary conditions for CFD simulations, and can further be used to validate CFD predictions. This work presents a framework to combine both spatiotemporal 4D MRI data and patient monitoring data with CFD simulation workflows. To assist practitioners, all aspects of the modeling workflow, from geometry reconstruction to results postprocessing, are illustrated and compared using three software packages (ansys, comsol, SimVascular) to predict hemodynamics in the thoracic aorta. A sensitivity analysis with respect to inlet boundary condition is presented. Results highlight the importance of 4D MRI data for improving the accuracy of flow predictions on the ascending aorta and the aortic arch. In contrast, simulation results for the descending aorta are less sensitive to the patient-specific inlet boundary conditions.
Cultural considerations related to climate change and transition on the University of Otago - Ōtepoti campus
Authors: Tawera Kaila , Thompson-Fawcett Daizy
Published: March 2023

Internationally, Indigenous communities have been some of the first to encounter the direct effects of climate change due to their relationship with the environment and its resources. Climate change can exacerbate political and economic marginalisation, loss of resources, social contexts and livelihoods. However, Iwi-Māori have been responding to the impacts of climate change and climate transition in creative ways, drawing on mātauranga Māori and hundreds of years of environmental experience and practice to devise solutions to tackle current and impending changes. Risk to Māori culture, heritage and social structures has been identified as major or extreme in the national climate change risk assessment. Therefore, using the University of Otago Otepoti campus as a case study, our research has explored some of the cultural imperatives and risks associated with climate change and transition. In our work, we have identified and mapped some of the key physical cultural features, local pūrakau, and aspirations for recognisable Indigenous futures on campus with a view to encouraging the integration of cultural considerations when reporting our climate transition endeavours.

As a result of this research, it is clear that the University would benefit from commissioning a detailed cultural narrative for the Ōtepoti site from mana whenua, which will help with developing actions such as the appropriate reintroduction of native flora and fauna corridors throughout the campus and the telling of local pūrakau throughout. In addition, the University would benefit from an enhanced bicultural partnership approach to leadership that could nurture the potential for the University environment to function as a sustainable Tiriti-based community.

Supervised by: Professor Michelle Thompson-Fawcett, Geography Department, Univeristy of OtagoScholarship co-funded by: Sustainability Office/Geography Department
Commuting Habits of the University of Otago Staff
Authors: Smith Caitlin
Published: March 2023

Transport contributes greatly to CO2 emissions in New Zealand. Studies have suggested that this is because there is a great  reliance on private cars with reduced incentive to use public or active transport. This research project looks at the current commuting habits of University of Otago employees and the potential barriers or facilitators surrounding a change in travel mode. This will be done by analyzing relevant academic literature which looks at barriers surrounding public transport use nationally and internationally. Data will also be obtained quantitatively through a survey which is sent to all university staff, and qualitatively through focus groups. The three research questions that this study will be conducted through are: What proportion  of university employees use different travel modes and what are the reasons for this? What is the potential for mode shift? What  are potential barriers or facilitators? Three major themes came up throughout this study and they relate to the frequency of  service, waiting time, and travel time. This research seeks to find out how University of Otago staff could be encouraged or facilitated to use public or zero-emission transport. Furthermore, this research supports New Zealand’s Net Zero Emissions by  2050 goal.

Supervised by: Dr Vanessa Beanland & Associate Professor Rebecca McLean, University of OtagoScholarship funded by: Sustainability Office/Psychology Department, University of Otago
A new feather mite of the genus Pelargolichus (Acariformes: Pterolichidae) from the Oriental White Stork Ciconia boyciana (Ciconiiformes: Ciconiidae) in Japan
Authors: Waki Tsukasa , Mironov Sergey V. , Nakajima Ami , Shimano Satoshi
Published: March 2023

A new feather mite Pelargolichus orientalis sp. nov. is described from the Oriental White Stork, Ciconia boyciana Swinhoe, 1873, one of the world’s most endangered bird species. This mite species was collected from feathers of the Oriental White Storks bred in the Tama Zoological Park in Japan. The native population of the Oriental White Stork and feather mites associated with this bird had been extinct in Japan since 1986. Wild individuals of this bird species were transported from the Eurasian Continent to Japanese breeding facilities, and in the 2000s, a small wild population was restored. The new mite species is presently distributed in natural fields in Japan along with its introduced host population. This study presents the first record of the feather mite genus Pelargolichus in Japan.
The impact of Cyflumetofen on demographic parameters of two predatory mites, Neoseiulus californicus (M-G) and Phytoseiulus persimilis (A-H)
Authors: Havasi Mohammadreza , Bandani Ali R. , Golpayegani Azadeh Zahedi
Published: March 2023

The assessment of the long-term negative effects of acaricides on the target and non-target mites can help determine the toxicity and side effects of acaricides. The sublethal concentrations can be very precise and affect populations at concentrations lower than the conventional concentration and may supplement our knowledge about its sublethal effects on the physiology and behavior of insects/mites. Furthermore, we exposed the adults' biocontrol agents mite, Phytoseiulus persimilis Athias-Henriot and Neoseuilus californicus McGregor, to the LC10 and LC30 concentrations of the Cyflumetofen and then assayed the effects of these concentrations on the growth and development of the next generations under laboratory conditions. Analyzed data showed that sublethal concentrations of cyflumetofen significantly affected both species' biological parameters, including the total lifetime, fecundity, and longevity of the treated biocontrol agents compared with the control treatment. Due to our results, when P. persimilis and N. californicus adults were exposed to LC30 concentration of cyflumetofen, the length of the oviposition period of the treated P.persimilis and N. californicus were 20.34 and 19.66 days, respectively. At the same time, these values for the control-treated P. persimilis and N. californicus were 22.51 and 22.21, respectively. The intrinsic rate of increase (r) in control were 0.203 and 0.238, while those treated with LC10 and LC30 of cyflumetofen were estimated to be 0.238 and 0.214 for P. persimilis and 0.203 and 0.223 days−1, for N. californicus, respectively. Therefore, using sublethal concentrations of cyflumetofen is emphasized for designing integrated pest management programs and makes it possible to use biocontrol agents to control the spider mite; thus, it would benefit the farmers and consumers in the long run.
Conductive TiN thin films grown by plasma-enhanced atomic layer deposition: Effects of N-sources and thermal treatments
Authors: Badie Clémence , Tissot Héloïse , Sciacca Beniamino , Barr Maïssa K. , Bachmann Julien , Vallée Christophe , Gautier Gaël , Defforge Thomas , Astie Vincent , Decams Jean-Manuel , Bechelany Mikhael , Santinacci Lionel
Published: March 2023

This work consists of optimizing TiN plasma-enhanced atomic layer deposition using two different N-sources: NH 3 and N 2. In addition to maximizing the growth per cycle (GPC) and to shorten the deposition duration, comprehensive in situ and ex situ physicochemical characterizations give valuable information about the influence of the N-source nature, their dilution in Ar, and the plasma power on layer’s final properties. N 2 and NH 3 dilutions within Ar are extensively investigated since they are critical to decreasing the mean free path ( ℓ) of plasma-activated species. A 1:1 gas ratio for the N-sources:Ar mixture associated with low flows (20 sccm) is optimal values for achieving highest GPCs (0.8 Å/cycle). Due to lower reactivity and shorter ℓ of the excited species, N 2 plasma is more sensitive to power and generator-to-sample distance, and this contributes to lower conformality than with NH 3 plasma. The resistivity of the initial amorphous films was high ( ≥ 1000 μ Ω  cm) and was significantly reduced after thermal treatment ( ≤ 400 μ Ω cm). This demonstrates clearly the beneficial effect of the crystallinity of the film conductivity. Though N 2 process appears slightly slower than the NH 3 one, it leads to an acceptable film quality. It should be considered since it is nonharmful, and the process could be further improved by using a reactor exhibiting optimized geometry.
Characterizing the rheology of lamellar gel networks with optical coherence tomography velocimetry
Authors: Watts Moore Owen , Waigh Thomas Andrew , Mendoza Cesar , Kowalski Adam
Published: March 2023

Lamellar gel networks based on mixtures of cetostearyl alcohol and a cationic surfactant, cetyl-trimethylammonium chloride, were studied using a combination of rheometry and optical coherence tomography (OCT) velocimetry. Experiments were conducted in a stress-controlled rheometer with a parallel plate geometry. Each formulation was found to exhibit a yield stress and thixotropy. The shear start-up behavior in response to a constant stress was directly observed using OCT velocimetry. Close to the yield stress, the velocity had a power law behavior with time after an initial period of transience. At larger stresses, the velocity undergoes two successive increases in power law scaling with time. When sheared at low, constant, shear rates 1–5 s−1, the fluids exhibit plug flow with strong wall slip at both rheometer plates. At rates of 10–150 s−1, the fluids separate into a distinctive three shear band morphology while the wall slip reduces. These rheological properties can be explained by a multilamellar vesicle to planar lamellae transition.
Determining the Delamanid Pharmacokinetics/Pharmacodynamics Susceptibility Breakpoint Using Monte Carlo Experiments
Authors: Liu Yongge , Moodley Mischka , Pasipanodya Jotam G. , Gumbo Tawanda
Published: March 2023

Antimicrobial susceptibility testing, based on clinical breakpoints that incorporate pharmacokinetics/pharmacodynamics (PK/PD) and clinical outcomes, is becoming a new standard in guiding individual patient therapy as well as for drug resistance surveillance. However, for most antituberculosis drugs, breakpoints are instead defined by the epidemiological cutoff values of the MIC of phenotypically wild-type strains irrespective of PK/PD or dose.
StkP- and PhpP-Mediated Posttranslational Modifications Modulate the S. pneumoniae Metabolism, Polysaccharide Capsule, and Virulence
Authors: Kant Sashi , Sun Youcheng , Pancholi Vijay
Published: March 2023

Pneumococcal Ser/Thr kinase (StkP) and its cognate phosphatase (PhpP) play a crucial role in bacterial cytokinesis. However, their individual and reciprocal metabolic and virulence regulation-related functions have yet to be adequately investigated in encapsulated pneumococci.
The Dysbiosis Triggered by First-Line Tuberculosis Antibiotics Fails to Reduce Their Bioavailability
Authors: Namasivayam Sivaranjani , Zimmerman Matthew , Oland Sandra , Wang Han , Mittereder Lara R. , Dartois Véronique , Sher Alan
Published: March 2023

Previous studies have shown that treatment of
Mycobacterium tuberculosis
infection with first-line antibiotics results in a long-lasting disruption of the host microbiota. Since the microbiome has been shown to influence the host availability of other drugs, we employed a mouse model to ask whether the dysbiosis resulting from either tuberculosis (TB) chemotherapy or a more aggressive course of broad-spectrum antibiotics might influence the pharmacokinetics of the TB antibiotics themselves.
Complete Genome Sequences of 11 Staphylococcus pseudintermedius Isolates from Dogs in the United States
Authors: Roozitalab Ashkan , Elsakhawy Ola , Phophi Lufuno , Kania Stephen A. , Abouelkhair Mohamed A.
Published: March 2023

We report here the genome sequences of 11 canine
Staphylococcus pseudintermedius
isolates from New York, New Hampshire, California, Pennsylvania, and Kansas. The sequencing information will enable spatial phylogenetic comparisons of staphylococcal species and other related species and will help in better understanding their virulence potential.
Near-Complete Whole-Genome Sequence of
Paenibacillus
sp. nov. Strain J5C2022, a Sucretolerant and Endospore-Forming Bacterium Isolated from Highly Concentrated Sugar Brine
Authors: Musa Siti Munirah , Siew Shing Wei , Tay Darren Dean , Ahmad Hajar Fauzan
Published: March 2023

Here, we present a 7.62-Mbp genome sequence of
Paenibacillus
sp. nov. strain J5C2022, a Gram-positive facultatively anaerobic bacterium that was isolated from 4-month-old fruit pickle brine and sequenced using the Illumina platform.
Spontaneous Genomic Variation as a Survival Strategy of Nosocomial Staphylococcus haemolyticus
Authors: Bouchami Ons , Machado Miguel , Carriço João André , Melo-Cristino José , de Lencastre Hermínia , Miragaia Maria
Published: March 2023

The introduction of medical devices and antibiotics into clinical practice have substantially improved patient quality of life and contributed to extended life expectancy. One of its most cumbersome consequences was the emergence of medical device-associated infections caused by multidrug-resistant and opportunistic bacteria such as
Staphylococcus haemolyticus
.
Emergence of
bla
IMI-2
- and
bla
IMI-16
-Producing Enterobacter asburiae in the Aquaculture Environment of Jiangsu, China
Authors: Che Jie , Wang Zhaoran , Song Yuqin , Guan Hongxia , Yuan Min , Chen Xia , Zhao Xiaofei , Xiao Yong , Zhang Yunfei , Sha Dan , Wang Chao , Feng Jie , Li Juan
Published: March 2023

IMI carbapenemases have been detected in clinical isolates of many bacterial species with systemic infection and cause a further burden on clinical treatment in China, but their source and distribution are still unclear. The study systematically investigated the distribution and transmission of the
bla
IMI
gene in aquaculture-related water bodies and aquatic products in Jiangsu Province, China, which is famous for its rich water resources and developed aquaculture industry.
Predicting Neurodegenerative Disease Using Prepathology Gut Microbiota Composition: a Longitudinal Study in Mice Modeling Alzheimer’s Disease Pathologies
Authors: Borsom Emily M. , Conn Kathryn , Keefe Christopher R. , Herman Chloe , Orsini Gabrielle M. , Hirsch Allyson H. , Palma Avila Melanie , Testo George , Jaramillo Sierra A. , Bolyen Evan , Lee Keehoon , Caporaso J. Gregory , Cope Emily K.
Published: March 2023

Recent studies have demonstrated alterations in the gut microbiota composition in mice modeling Alzheimer’s disease (AD) pathologies; however, these studies have only included up to 4 time points. Our study is the first of its kind to characterize the gut microbiota of a transgenic AD mouse model, fortnightly, from 4 weeks of age to 52 weeks of age, to quantify the temporal dynamics in the microbial composition that correlate with the development of disease pathologies and host immune gene expression.
A Specific High Toxicity of Xinjunan (Dioctyldiethylenetriamine) to
Xanthomonas
by Affecting the Iron Metabolism
Authors: Zang Hao-Yu , Yang Xue , Gu Chun-Yan , Sun Jia-Zhi , Pan Rui , Wang Yong-Xing , Gao Tong-Chun , Yuan Shan-Kui , Chen Yu
Published: March 2023

Sustainable chemical control for rice bacterial leaf blight caused by
Xanthomonas oryzae
pv.
oryzae
need to be developed due to limited bactericides with high efficiency, low cost, and low toxicity in China. This present study verified a broad-spectrum fungicide named Xinjunan possessing a specific high toxicity to
Xanthomonas
pathogens, which were further confirmed by affecting the cellular iron metabolism of
Xoo
as a novel mode of action.
Short-Lived Antibody-Mediated Saliva Immunity against SARS-CoV-2 after Vaccination
Authors: Madsen Johannes Roth , Holm Bettina Eide , Pérez-Alós Laura , Bayarri-Olmos Rafael , Rosbjerg Anne , Fogh Kamille , Pries-Heje Mia Marie , Møller Dina Leth , Hansen Cecilie Bo , Heftdal Line Dam , Hasselbalch Rasmus Bo , Hamm Sebastian Rask , Frikke-Schmidt Ruth , Hilsted Linda , Nielsen Susanne Dam , Iversen Kasper Karmark , Bundgaard Henning , Garred Peter
Published: March 2023

Knowledge about the persistence of salivary immunity after SARS-CoV-2 vaccination is limited, and information on this topic could prove important for vaccine strategy and development. We hypothesized that salivary immunity would wane rapidly after vaccination.
The Hardest LL(k) Language
Authors: Mrykhin Mikhail , Okhotin Alexander
Published: March 2023

This paper establishes an analogue of Greibach’s hardest language theorem (“The hardest context-free language”, SIAM J. Comp., 1973, http://dx.doi.org/10.1137/0202025 ) for the classical family of LL([Formula: see text]) languages. The first result is that there is a language [Formula: see text] defined by an LL(1) grammar in the Greibach normal form, to which every language [Formula: see text] defined by an LL(1) grammar in the Greibach normal form can be reduced by a homomorphism, that is, [Formula: see text] if and only if [Formula: see text]. Then it is shown that this statement does not hold for the full class of LL([Formula: see text]) languages. The other hardest language theorem is then established in the following form: there is a language [Formula: see text] defined by an LL(1) grammar in the Greibach normal form, such that, for every language [Formula: see text] defined by an LL([Formula: see text]) grammar, with [Formula: see text], there exists a homomorphism [Formula: see text], for which [Formula: see text] if and only if [Formula: see text] [Formula: see text] [Formula: see text], where [Formula: see text] is a new symbol. The results lead to two robust language families: the closures of the languages defined by LL(1) grammars in the Greibach normal form under inverse homomorphisms and under inverse finite transductions.
Soliton solutions to generalized (2+1)-dimensional Hietarinta-type equation and resonant NLSE along with stability analysis
Authors: Ali Kashif , Seadawy Aly R. , Aziz Noor , Rizvi Syed T. R.
Published: March 2023

This paper discusses the generalized [Formula: see text]-dimensional Hietarinta-type fourth-order nonlinear equation (GHTE) and Resonant nonlinear Schrödinger equation (RNLSE). We will study the soliton solutions of the GHTE as well as RNLSE by the renowned, efficient and successful method called sub-ODE technique. The solutions are categorized as dark soliton, periodic, rational, positive, hyperbolic and Weierstrass elliptic solutions (WES). Stability analysis of the solutions is performed for both the models. Later on, these results will be displayed graphically by 3D, 2D, contour, density and streamline plots which describe the behavior of the waves.
Spectroscopic investigation of atmospheric pressure ‘micro-plasma needle’
Authors: Masood Asad , Zaman Ayesha , Rehman N. U. , S.M.H M. Aniq , Khan M. Ibrahim , S. A M. Ali
Published: March 2023

Plasma-based sterilization at atmospheric pressure in plasma needle configuration is a recently developing technique that has numerous applications in heat-sensitive materials and enhances biosensor properties. In this study, the capacitively coupled He–O2/Ar and He–N2/Ar mixtures [Formula: see text]-plasma at atmospheric pressure is characterized to find out the optimum condition of plasma-based sterilization for plasma needle. Trace rare gas actinometry based on optical emission spectroscopy has been used to estimate the [O] and [N] atomic densities as a function of discharge parameters i.e., applied pulsing voltage, gases concentration and different flow rates. Ar-1line Ar[Formula: see text] at 750 nm, N-I line [Formula: see text] at 746.8 nm and O-I line [Formula: see text] at 844.6 nm is used to determine the atomic densities of oxygen [O] and nitrogen [N]. Using the Boltzmann plot, the rotational temperature of He–N2/Ar and He–O2/Ar was calculated from the rotational levels of the “first negative system” (FNS) [Formula: see text]. The temperature of the gas increases as the pulsed DC power increases, but it drops as the gas flow rate in the mixture increases. The actinometric results show that both densities increase with applied pulsing voltage and molecular concentration of oxygen and nitrogen. Moreover, it is also observed that emission intensity ratios ([Formula: see text] and [Formula: see text]) also increase with an increase in applied pulsing voltage but they decrease with an increase in flow rate. Based on these results, it is suggested that the optimum conditions, in terms of [O] and [N] atomic densities, for plasma-based sterilization in needle configuration are 4% oxygen and nitrogen concentration at 4 kV applied pulsing voltage and 100[Formula: see text]SCCM flow rate.
Channelopathies in Breast Cancer and Gynecological Cancers
Authors: Yesudas Chandana , Maheshwari Uma , Devaraj Illakkiam
Published: March 2023

Increasing evidence shows that ion channels play a significant role in cell proliferation, migration, apoptosis and differentiation. Many research works in gynecological cancer suggest that ion channels are involved in aberrant tumor growth and upregulation or downregulation of ion channels results in tumor growth arrest. Channelopathies are a diverse set of inherited mutations of ion channels that result in altered biophysical properties. In normal cells, there is a switch between cell growth and cell death which apparently depend upon the temporal organization and magnitude of different ion channels. There is a need for specific ion channel blockers which can abrogate the cellular mechanism of the cancer cell. Typically the impact of ion channels on cancer depends upon the magnitude and temporal organization of the ion channel activation and the activity of other signaling mechanisms. Membrane proteins are responsible for ionic homeostasis in ion channels. As cancer can be linked with the altered biophysical properties of ion channels a border context of different ion channels in cancer seems absolutely appropriate. The field of onco-channelopathies is rapidly expanding and understanding the pathophysiological mechanisms underlying the development of cancer enables researchers to better diagnose and develop treatment options for cancer. This review focuses on the role of ion channels in breast cancer and other gynecological cancers including ovarian cancer and cervical cancer, and how they contribute to tumor development.
Understanding the Ni Migration in Solid Oxide Cell: A Coupled Experimental and Modeling Approach
Authors: Rorato Léa , Shang Yijing , Yang Shenglan , Hubert Maxime , Couturier Karine , Zhang Lijun , Vulliet Julien , Chen Ming , Laurencin Jérôme
Published: March 2023

A long-term test of 2000 h has been carried out on a typical solid oxide cell in electrolysis mode at −1 A.cm−2 and 750 °C. The 3D reconstructions of the pristine and aged cermet have revealed a strong Ni depletion at the electrolyte interface. To explain this result, an electrochemical and phase-field model has been developed to simulate the Ni migration in Ni/YSZ electrode. For this purpose, a mechanism has been proposed that takes into account the impact of polarization on the Ni/YSZ wettability. In this approach, it assumes that the Ni/YSZ interfacial energy is changed by the concentration of oxygen vacancies in the electrochemical double layer. Thanks to the model, the Ni migration has been computed in the same condition than the experiment and complemented by a simulation in reverse condition in SOFC mode. In good agreement with the experiment, the simulations have revealed a strong Ni depletion at the electrolyte interface after operation under electrolysis current. On the contrary, a negligible Ni redistribution with a very slight Ni enrichment has been predicted at the electrolyte interface after SOFC operation. These results tend to prove the relevance of the mechanism.
The Effect of Ambient Ageing on the Corrosion Protective Properties of a Lithium-Based Conversion Layer
Authors: Li Ziyu , Homborg Axel , Gonzalez-Garcia Yaiza , Visser Peter , Soleimani Mohammad , Mol Arjan
Published: March 2023

The influence of ageing under ambient conditions on the corrosion protective behaviour of a lithium-based conversion layer on AA2024-T3 is studied in this work. Conversion layers aged at ambient conditions for relatively short times (0 h and 4 h), show an initial high degree of corrosion inhibition but a much lower protectiveness after the inhibition stage terminates. Conversion layers with relatively long ageing times (24 h and 72 h) show a rather stable corrosion resistance which is higher than that of short-time aged samples. It is hypothesized that the freshly-formed conversion layer has trapped a certain amount of lithium ions and water molecules, leading to ongoing and heterogeneous growth of the conversion layer with time under ambient indoor conditions. Moreover, conversion layers with short ageing times show early-stage active corrosion protection by lithium-ion release.
Comprehensive Analysis Based on the Cancer Immunotherapy and Immune Activation of Gastric Cancer Patients
Authors: Jiang Feng , Ma Qilong
Published: March 2023

When it comes to aggressiveness and prognosis, immune cells play an important role in the microenvironment of gastric cancer (GC). Currently, there is no well-established evidence that immune status typing is reliable as a prognostic tool for gastric cancer. This study aimed to develop a genetic signature based on immune status typing for the stratification of gastric cancer risk. TCGA data were used for gene expression and clinical characteristics analysis. A ssGSEA algorithm was applied to type the gastric cancer cohorts. A multivariate and univariate Cox regression and a lasso regression were conducted to determine which genes are associated with gastric cancer prognosis. Finally, we were able to produce a 6-gene prognostic prediction model using immune-related genes. Further analysis revealed that the prognostic prediction model is closely related to the prognosis of patients with GC. Nomograms incorporating genetic signatures and risk factors produced better calibration results. The relationship between the risk score and gastric cancer T stage was also significantly correlated with multiple immune markers related to specific immune cell subsets. According to these results, patients’ outcomes and tumor immune cell infiltration correlate with risk scores. In addition, immune cellular-based genetic signatures can contribute to improved risk stratification for gastric cancer. Clinical decisions regarding immunotherapy and followup can be guided by these features.
Surgical Management of Atraumatic Rupture of Splenic Artery Aneurysm with Spleen Preservation in a Regional Australian Hospital
Authors: Hamilton Emma Jane , Ngugi Samuel , Kotakadeniya Rasika
Published: March 2023

A 41-year-old male presented to the emergency department of a regional Australian hospital with chest and abdominal pain. He became rapidly haemodynamically unstable and was diagnosed with a ruptured splenic artery aneurysm and large volume hemoperitoneum. Due to the regional location of our small hospital, endovascular services are not available and the patient required emergency laparotomy. At laparotomy, a 2 L hemoperitoneum was evacuated, and the bleeding splenic artery aneurysm was identified and controlled. The aneurysm was approached with a unique technique via division of the gastro colic omentum to enter the lesser sac. This allowed adequate exposure of the splenic artery and proximal and distal control of the vessel was achieved. Adequate perfusion to the spleen was preserved by this surgical technique and splenectomy was therefore not required. This study details the management of this patient, details of the interoperative technique, and a discussion regarding splenic artery aneurysms. Splenic artery control and ligation without splenectomy may be considered in appropriate patients and splenectomy is therefore not always required in cases of hemodynamic instability where open surgical management is performed.
3D Modeling of Mine Protection Complex Steel Structure Based on BIM Technology
Authors: Li Fenhong , Wang Zaisheng , Pang Chongan , Yang Haiping
Published: March 2023

The objective of this paper is to study the antidamage ability of beam column joints in complex steel structures under external forces and to improve the safety of such structures. In this study, a three-dimensional model of complex steel structure based on BIM technology is proposed by analyzing and calculating the ultimate strength of complex steel structure for mine protection. The vibration control algorithm of complex steel structure for mine protection is designed, and the boundary elastic constraint conditions are determined. According to the constraint conditions, the vibration characteristics of complex steel structures for mining are analyzed. The experimental results show that the maximum displacement of the design model is reduced by half compared with that before optimization, which can meet the design requirements.
Is Financial Education Positively Associated with Consumer Stock Market Satisfaction? Evidence from China
Authors: Chen Fuzhong , Zhang Ji , Xiao Jing Jian , Chen Jinwei
Published: March 2023

This study aims to investigate the associations between financial education and consumer stock market satisfaction. Consumer financial education is measured through the objective aspect incorporating formal and informal financial knowledge education, and the subjective aspect is reflected through consumers’ attitudes toward financial education. Using data from China’s urban consumers, the results indicate a positive association between financial education and consumer stock market satisfaction. The findings suggest that consumers who were financially literate at high schools or colleges are more satisfied in participating in the stock market. Moreover, consumers who spend more money and time, as well as those who think financial education is more important, feel more satisfied in participating in stock market investment activities. The results imply that it is necessary to increase the supply of formal financial education in high schools and universities, encourage consumers to invest more in the informal education of financial knowledge, and promote policymakers to formulate informative policies to make consumers aware of the importance of financial education.
Association between Cognitive Impairment and Hippocampal Subfield Volumes in Multiple System Atrophy
Authors: Sugiyama Atsuhiko , Yokota Hajime , Hirano Shigeki , Wang Jiaqi , Ito Shoichi , Kuwabara Satoshi
Published: March 2023

This study aimed to explore morphological changes of hippocampal subfields in patients with multiple system atrophy (MSA) with and without cognitive impairment using FreeSurfer-automated segmentation of hippocampal subfield techniques and their relationship with cognitive function. We enrolled 75 patients with MSA classified as cognitively impaired MSA (MSA-CI, n = 40) and cognitively preserved MSA (MSA-CP, n = 35), as well as 68 healthy controls. All participants underwent three-dimensional volume T1-weighted magnetic resonance imaging. The hippocampal subfield volume was measured using FreeSurfer version 7.2 and compared among groups. Regression analyses were performed between the hippocampal subfield volumes and cognitive variables. Compared with healthy controls, the volume of the right cornu ammonis (CA) 2/3 was significantly lower in the MSA-CI group (

P
=
0.029

) and that of the left fimbria was significantly higher in the MSA-CP group (

P
=
0.046

). Results of linear regression analysis showed that the right CA2/3 volume was significantly correlated with the Frontal Assessment Battery score in patients with MSA (adjusted R2 = 0.282, β = 0.227, and

P
=
0.041

). The hippocampal subfield volume decreased in patients with MSA-CI, even at the early disease stages. Specific structural changes in the hippocampus might be associated with cognitive deficits in MSA.
A New Quotient and Iterative Detection Method in an Affine Krylov Subspace for Solving Eigenvalue Problems
Authors: Liu Chein-Shan , Chang Jiang-Ren , Shen Jian-Hung , Chen Yung-Wei
Published: March 2023

The paper solves the eigenvalues of a symmetric matrix by using three novel algorithms developed in the m-dimensional affine Krylov subspace. The n-dimensional eigenvector is superposed by a constant shifting vector and an m-vector. In the first algorithm, the m-vector is derived as a function of eigenvalue by maximizing the Rayleigh quotient to generate the first characteristic equation, which, however, is not easy to determine the eigenvalues since its roots are not of simple ones, exhibiting turning points, spikes, and even no intersecting point to the zero line. To overcome that difficulty by the first algorithm, we propose the second characteristic equation through a new quotient with the inner product of the shifting vector to the eigen-equation. The Newton method and the fictitious time integration method are convergent very fast due to the simple roots of the second characteristic equation. For both symmetric and nonsymmetric eigenvalue problems solved by the third algorithm, we develop a simple iterative detection method to maximize the Euclidean norm of the eigenvector in terms of the eigen-parameter, of which the peaks of the response curve correspond to the eigenvalues. Through a few finer tunings to the smaller intervals sequentially, a very accurate eigenvalue and eigenvector can be obtained. The efficiency and accuracy of the proposed iterative algorithms are verified and compared to the Lanczos algorithm and the Rayleigh quotient iteration method.
Impuesto al valor agregado a los servicios
Authors: Romero Rafael , Veloso Sergio
Published: March 2023

A partir del 1 de enero de 2023, se comenzó a aplicar el Impuesto al Valor Agregado (IVA) a algunas categorías de servicios. La Ley 21.420 de febrero de 2022, modifica parte del Decreto Ley 825, la cual grava con el IVA a los servicios, con excepción de algunos servicios especialmente contemplados en la reglamentación vigente... continuar leyendo
Three-Dimensional Assessment of Radiographic Changes after Indirect Pulp Capping Using Silver Diamine Fluoride with or without Potassium Iodide in Young Permanent Teeth (12-Month RCT)
Authors: Baraka Marwa Mohamed Ahmed Lotfy , Cevidanes Lucia , Tekeya Magda , Bakry Niveen , Ruellas Antonio , Botero Tatiana , Benavides Erika , Fontana Margherita
Published: March 2023

The aim of this study was to conduct a three-dimensional (3D) evaluation of radiographic changes after indirect pulp capping (IPC) with silver diamine fluoride (SDF) with or without potassium iodide (KI) and resin-modified glass ionomer cement (RMGIC) in deep carious young permanent molars using cone-beam computed tomography (CBCT). 108 first permanent molars with deep occlusal cavitated caries lesions, in forty-nine 6- to 9-year-old children, were randomly allocated to one of 3 groups (n = 36) and treated with SDF+KI, SDF, and RMGIC as IPC materials. CBCT scans were taken at 0 and 12 months to assess tertiary dentin formation (volume and grey level intensity), increase in root length, and pathological changes such as secondary caries, periapical radiolucency, internal resorption, and obliteration of the pulp. The 3D image analysis procedures were performed using ITK-SNAP and 3D Slicer CMF. Comparisons were made using analysis of variance with a fixed effect for treatment and random effects for patient and patient-by-treatment to account for within-patient correlations. A two-sided 5% significance level was used. There were no significant differences among the three groups regarding tertiary dentin volume (p = 0.712) and grey level intensity (p = 0.660), increase in root length (p = 0.365), prevention of secondary caries (p = 0.63), and periapical radiolucency (p = 0.80) in the analysed 69 CBCT scans. The study did not find differences among the groups regarding quality and quantity of tertiary dentin formed, increase in root length, absence of secondary caries, and other signs of failure as shown by CBCT. Clinical Significance: The results show no significant differences in radiographic outcomes (quality and quantity of tertiary dentin formed, increase in root length, absence of secondary caries, and other signs of failure) when using SDF+KI, SDF, and RMGIC in IPC. The results of this study can help guide treatment decision-making regarding use of SDF and SDF+KI as IPC materials in deep cavitated lesions.
Estradiol Enhances the Development of Addiction-Like Features in a Female Rat Model of Opioid Use Disorder
Authors: Towers Eleanor Blair , Setaro Ben , Lynch Wendy J.
Published: March 2023

Introduction: Women are more vulnerable than men in many aspects of opioid use disorder (OUD); a major theory of sex differences in substance use disorders is that these differences are due to ovarian hormones with estradiol enhancing vulnerability in females. However, most of this evidence is for psychostimulants and alcohol; evidence with opioids is sparse. Thus, the goal of this study was to determine the impact of estradiol on vulnerability in females in a rat model of OUD. Method: Following self-administration training, ovariectomized (OVX) females with (E) or without (V) estradiol replacement were given extended (24 h/day), intermittent access (2, 5-min trials/h) to fentanyl for 10 days. Then, the development of three key features of OUD were assessed, including physical dependence, defined by the magnitude and time course of weight loss during withdrawal; an enhanced motivation for fentanyl, assessed using a progressive-ratio schedule; and relapse vulnerability, assessed using an extinction/cue-induced reinstatement procedure. These later two characteristics were examined following 14 days of withdrawal when the phenotypes are known to be highly expressed. Results: OVX+E females self-administered markedly higher levels of fentanyl under extended, intermittent-access conditions and showed a longer time course of physical dependence, a greater increase in motivation for fentanyl, and an enhanced sensitivity to the reinstating effects of fentanyl-associated cues compared to OVX+V rats. Severe health complications were also observed in OVX+E, but not OVX+V females, during withdrawal. Conclusion: These results indicate that, as with findings with psychostimulants and alcohol, estradiol enhances vulnerability in females to developing opioid addiction-like features and serious opioid-related health complications.