bluuebunny/crossref_metadata_2025 huggingface dataset:
Point-of-care ultrasound (POCUS) as the keystone investigation in undifferentiated dyspnoea
Authors: Montemerani Sara , Donati Valeria , Di Pietra Nicola , Iannelli Giovanni
Published: June 2020

Dyspnoea is defined as a subjective perception of laboured breathing. It is a common cause of access to the emergency department (ED), it has a high rate of intensive care unit admission and a high mortality. The most common causes of dyspnoea in the adult include pneumonia, heart failure, chronic obstructive pulmonary disease, pulmonary embolism and asthma. Due to the high variety of dyspnoea’s causes, the need for a rapid and accurate diagnosis puts the emergency physician in trouble. Moreover, standard tests such as chest radiography, B-type natriuretic peptide and d-dimer require time and may be less useful in patients with respiratory failure who require urgent therapy. Point-of-care ultrasound (POCUS) is rapid, non-invasive, repeatable and a useful tool in evaluating patients with acute and severe dyspnoea. This case report demonstrates the usefulness of POCUS in a patient with undifferentiated respiratory failure presenting to the ED.
Use of an electronic decision support tool to reduce polypharmacy in elderly people with chronic diseases: cluster randomised controlled trial
Authors: Rieckert Anja , Reeves David , Altiner Attila , Drewelow Eva , Esmail Aneez , Flamm Maria , Hann Mark , Johansson Tim , Klaassen-Mielke Renate , Kunnamo Ilkka , Löffler Christin , Piccoliori Giuliano , Sommerauer Christina , Trampisch Ulrike S , Vögele Anna , Woodham Adrine , Sönnichsen Andreas
Published: June 2020

Objective

To evaluate the effects of a computerised decision support tool for comprehensive drug review in elderly people with polypharmacy.

Design

Pragmatic, multicentre, cluster randomised controlled trial.

Setting

359 general practices in Austria, Germany, Italy, and the United Kingdom.

Participants

3904 adults aged 75 years and older using eight or more drugs on a regular basis, recruited by their general practitioner.

Intervention

A newly developed electronic decision support tool comprising a comprehensive drug review to support general practitioners in deprescribing potentially inappropriate and non-evidence based drugs. Doctors were randomly allocated to either the electronic decision support tool or to provide treatment as usual.

Main outcome measures

The primary outcome was the composite of unplanned hospital admission or death by 24 months. The key secondary outcome was reduction in the number of drugs.

Results

3904 adults were enrolled between January and October 2015. 181 practices and 1953 participants were assigned to electronic decision support (intervention group) and 178 practices and 1951 participants to treatment as usual (control group). The primary outcome (composite of unplanned hospital admission or death by 24 months) occurred in 871 (44.6%) participants in the intervention group and 944 (48.4%) in the control group. In an intention-to-treat analysis the odds ratio of the composite outcome was 0.88 (95% confidence interval 0.73 to 1.07; P=0.19, 997 of 1953
v
1055 of 1951). In an analysis restricted to participants attending practice according to protocol, a difference was found favouring the intervention (odds ratio 0.82, 95% confidence interval 0.68 to 0.98; 774 of 1682
v
873 of 1712, P=0.03). By 24 months the number of prescribed drugs had decreased in the intervention group compared with control group (uncontrolled mean change −0.42
v
0.06: adjusted mean difference −0.45, 95% confidence interval −0.63 to −0.26; P<0.001).

Conclusions

In intention-to-treat analysis, a computerised decision support tool for comprehensive drug review of elderly people with polypharmacy showed no conclusive effects on the composite of unplanned hospital admission or death by 24 months. Nonetheless, a reduction in drugs was achieved without detriment to patient outcomes.

Trial registration

Current Controlled Trials
ISRCTN10137559
.
Immunomodulation to enhance the efficacy of an HPV therapeutic vaccine
Authors: Smalley Rumfield Claire , Pellom Samuel T , Morillon II Y Maurice , Schlom Jeffrey , Jochems Caroline
Published: June 2020

Background

While prophylactic human papillomavirus (HPV) vaccines will certainly reduce the incidence of HPV-associated cancers, these malignancies remain a major health issue. PDS0101 is a liposomal-based HPV therapeutic vaccine consisting of the immune activating cationic lipid R-DOTAP and HLA-unrestricted HPV16 peptides that has shown in vivo CD8+ T cell induction and safety in a phase I study. In this report, we have employed the PDS0101 vaccine with two immune modulators previously characterized in preclinical studies and which are currently in phase II clinical trials. Bintrafusp alfa (M7824) is a first-in-class bifunctional fusion protein composed of the extracellular domains of the transforming growth factor-β receptor type II (TGFβRII) fused to a human IgG1monoclonal antibody blocking programmed cell death protein-1 ligand (PDL1), designed both as a checkpoint inhibitor and to bring the TGFβRII ‘trap’ to the tumor microenvironment (TME). NHS-interleukin-12 (NHS-IL12) is a tumor targeting immunocytokine designed to bring IL-12 to the TME and thus enhance the inflammatory Th1 response.

Methods

We employed TC-1 carcinoma (expressing HPV16 E6 and E7 and devoid of PDL1 expression) in a syngeneic mouse model in monotherapy and combination therapy studies to analyze antitumor effects and changes in immune cell types in the spleen and the TME.

Results

As a monotherapy, the PDS0101 vaccine generated HPV-specific T cells and antitumor activity in mice bearing HPV-expressing mEER oropharyngeal and TC-1 lung carcinomas. When used as a monotherapy in the TC-1 model, NHS-IL12 elicited antitumor effects as well as an increase in CD8+ T cells in the TME. When used as a monotherapy, bintrafusp alfa did not elicit antitumor effects or any increase in T cells in the TME. When all three agents were used in combination, maximum antitumor effects were observed, which correlated with increases in T cells and T-cell clonality in the TME.

Conclusion

These studies provide the rationale for the potential clinical use of combinations of agents that can (1) induce tumor-associated T-cell responses, (2) potentiate immune responses in the TME and (3) reduce immunosuppressive entities in the TME.
Combined DLL3-targeted bispecific antibody with PD-1 inhibition is efficient to suppress small cell lung cancer growth
Authors: Chen Xin , Amar Norhan , Zhu Yuankui , Wang Chunguang , Xia Chunjiao , Yang Xiaoqing , Wu Dongde , Feng Mingqian
Published: June 2020

Background

Small cell lung cancer (SCLC) accounts for 15% of lung cancers, and the primary treatment of this malignancy is chemotherapy and radiotherapy. Delta-like 3 (DLL3) is an attractive target for SCLC immunotherapy since its expression is highly restricted to SCLC with a neglectable appearance on normal adult tissues. In the current study, we aimed to explore the efficacy of DLL3-targeted SCLC immunotherapy via the engagement of T cell.

Methods

As a proof of concept, we constructed DLL3-targeted bispecific antibody and chimeric antigen receptor (CAR)-modified T cells. In vitro and in vivo tumor-suppression activity of these treatments alone or in combination with a Program Death-1 (PD-1) inhibitory antibody was evaluated.

Results

In vitro studies showed that both DLL3 bispecific antibody and CAR-T efficiently killed DLL3-positive cancer cells, including the native SCLC cell lines H446, H196, H82, and the artificial A431 cells that were forcefully overexpressing DLL3. In vivo studies in xenograft mouse models demonstrated that both bispecific antibody and CAR-T suppressed the tumor growth, and combination therapy with PD-1 inhibitory antibody dramatically improved the efficacy of the DLL3 bispecific antibody, but not the CAR-T cells.

Conclusions

Our results demonstrated that DLL3-targeted bispecific antibody plus PD-1 inhibition was effective in controlling SCLC growth.
Immune-related (IR)-pneumonitis during the COVID-19 pandemic: multidisciplinary recommendations for diagnosis and management
Authors: Naidoo Jarushka , Reuss Joshua E , Suresh Karthik , Feller-Kopman David , Forde Patrick M , Mehta Steinke Seema , Rock Clare , Johnson Douglas B , Nishino Mizuki , Brahmer Julie R
Published: June 2020

Immune-related (IR)-pneumonitis is a rare and potentially fatal toxicity of anti-PD(L)1 immunotherapy. Expert guidelines for the diagnosis and management of IR-pneumonitis include multidisciplinary input from medical oncology, pulmonary medicine, infectious disease, and radiology specialists. Severe acute respiratory syndrome coronavirus 2 is a recently recognized respiratory virus that is responsible for causing the COVID-19 global pandemic. Symptoms and imaging findings from IR-pneumonitis and COVID-19 pneumonia can be similar, and early COVID-19 viral testing may yield false negative results, complicating the diagnosis and management of both entities. Herein, we present a set of multidisciplinary consensus recommendations for the diagnosis and management of IR-pneumonitis in the setting of COVID-19 including: (1) isolation procedures, (2) recommended imaging and interpretation, (3) adaptations to invasive testing, (4) adaptations to the management of IR-pneumonitis, (5) immunosuppression for steroid-refractory IR-pneumonitis, and (6) management of suspected concurrent IR-pneumonitis and COVID-19 infection. There is an emerging need for the adaptation of expert guidelines for IR-pneumonitis in the setting of the global COVID-19 pandemic. We propose a multidisciplinary consensus on this topic, in this position paper.
Can nutrient additions facilitate recovery of Pacific salmon?
Authors: Benjamin Joseph R. , Bellmore J. Ryan , Whitney Emily , Dunham Jason B.
Published: June 2020

Multiple restoration actions have been implemented in response to declining salmon populations. Among these is the addition of salmon carcasses or artificial nutrients to mimic marine-derived nutrients historically provided by large spawning runs of salmon. A key assumption in this approach is that increased nutrients will catalyze salmon population growth. Although effects on aquatic ecosystems have been observed during treatments, it is unclear whether permanent population increases for salmon will occur. To test this assumption and address associated uncertainties, we linked a food web model with a salmon life cycle model to examine whether carcass additions in a river reach would improve conditions for salmon in the long term. Model results confirmed immediate increases in the biomass of periphyton, macroinvertebrates, and fish during carcass additions. In turn, juvenile salmon grew larger and experienced improved freshwater and smolt survival, which translated to a greater number of adults returning to spawn. However, once additions ceased, salmon abundance returned to pretreatment levels, which, based on our model, is owing to a combination of instream and out-of-basin factors. Overall, results of this work suggest that benefits during carcass and nutrient additions may not translate into persistent productivity of salmon unless additions are sustained indefinitely or other limiting factors are addressed.
Drug discovery and chemical probing inDrosophila
Authors: Millet-Boureima Cassandra , Selber-Hnatiw Susannah , Gamberi Chiara
Published: June 2020

Flies are increasingly utilized in drug discovery and chemical probing in vivo, which are novel technologies complementary to genetic probing in fundamental biological studies. Excellent genetic conservation, small size, short generation time, and over one hundred years of genetics make Drosophila an attractive model for rapid assay readout and use of analytical amounts of compound, enabling the experimental iterations needed in early drug development at a fraction of time and costs. Here, we describe an effective drug-testing pipeline using adult flies that can be easily implemented to study several disease models and different genotypes to discover novel molecular insight, probes, quality lead compounds, and develop novel prototype drugs.
Factoring octonion polynomials
Authors: Chapman Adam
Published: June 2020

We provide an analogue of Wedderburn’s factorization method for central polynomials with coefficients in an octonion division algebra, and present an algorithm for fully factoring polynomials of degree [Formula: see text] with [Formula: see text] conjugacy classes of roots, counting multiplicities.
CLIMATE AND HEALTH BENEFITS OF PHASING OUT IRON & STEEL PRODUCTION CAPACITY IN CHINA: FINDINGS FROM THE IMED MODEL
Authors: LI BO-SHU , CHEN YAN , ZHANG SHAOHUI , WU ZHERU , COFALA JANUSZ , DAI HANCHENG
Published: June 2020

In recognition of the negative climate change and deteriorative air quality, the iron and steel industry in China was subject to production capacity phase-out policy (PCPP), which is deeply influencing industrial restructuring and national emission reduction targets. However, researches that quantitatively estimated the comprehensive impacts of such structural adjustment policy remain scant. For this purpose, this study expands and soft-links between GAINS and IMED models to characterize the impacts of climate change and PM[Formula: see text]-attributed health co-benefits. Results showed the PCPP based on scale limitation to eliminate backward capacities in the Beijing-Tianjin-Hebei region yields total benefits of 34.9 billion Yuan (4.2 billion USD), 89% of total coming from energy saving and carbon mitigation, more than policy costs (20.0 billion Yuan) in 2020, but the gap between benefit-cost will keep narrowing to [Formula: see text]2.8 billion Yuan ([Formula: see text]0.3 billion USD) in 2020–2030, indicating that policy improvement is needed in the long run. To further increase policy co-benefits and achieve multiple policy targets, the policymaker should readjust the PCPP by switching scale limitation to energy efficiency constraint. If doing that, the difference of benefit-cost will achieve 42.5 billion Yuan (5.1 billion USD). The regional disparity also exits due to the diverse ratio of benefit-cost in the selected provinces, calling for necessary fiscal incentives to the less developed area, e.g., Hebei, to promote closer integration.
Self-aware Cyber-Physical Systems
Authors: Bellman K. , Landauer C. , Dutt N. , Esterle L. , Herkersdorf A. , Jantsch A. , TaheriNejad N. , Lewis P. R. , Platzner M. , Tammemäe K.
Published: June 2020

In this article, we make the case for the new class of
Self-aware Cyber-physical Systems.
By bringing together the two established fields of cyber-physical systems and self-aware computing, we aim at creating systems with strongly increased yet managed autonomy, which is a main requirement for many emerging and future applications and technologies. Self-aware cyber-physical systems are situated in a physical environment and constrained in their resources, and they understand their own state and environment and, based on that understanding, are able to make decisions autonomously at runtime in a self-explanatory way. In an attempt to lay out a research agenda, we bring up and elaborate on five key challenges for future self-aware cyber-physical systems: (i) How can we build resource-sensitive yet self-aware systems? (ii) How to acknowledge situatedness and subjectivity? (iii) What are effective infrastructures for implementing self-awareness processes? (iv) How can we verify self-aware cyber-physical systems and, in particular, which guarantees can we give? (v) What novel development processes will be required to engineer self-aware cyber-physical systems? We review each of these challenges in some detail and emphasize that addressing all of them requires the system to make a comprehensive assessment of the situation and a continual introspection of its own state to sensibly balance diverse requirements, constraints, short-term and long-term objectives. Throughout, we draw on three examples of cyber-physical systems that may benefit from self-awareness: a multi-processor system-on-chip, a Mars rover, and an implanted insulin pump. These three very different systems nevertheless have similar characteristics: limited resources, complex unforeseeable environmental dynamics, high expectations on their reliability, and substantial levels of risk associated with malfunctioning. Using these examples, we discuss the potential role of self-awareness in both highly complex and rather more simple systems, and as a main conclusion we highlight the need for research on above listed topics.
The best place to build a subway
Authors: Helland Pat
Published: June 2020

Building projects despite (and because of) existing complex systems.
Gordian
Authors: Weber Matthew , Jin Baihong , Lederman Gil , Shoukry Yasser , Lee Edward A. , Seshia Sanjit , Sangiovanni-Vincentelli Alberto
Published: June 2020

Accurate localization from Cyber-Physical Systems (CPS) is a critical enabling technology for context-aware applications and control. As localization plays an increasingly safety-critical role, location systems must be able to identify and eliminate faulty measurements to prevent dangerously inaccurate localization. In this article, we consider the range-based localization problem and propose a method to detect coordinated adversarial corruption on anchor positions and distance measurements. Our algorithm, G
ordian
, rapidly finds attacks by identifying geometric inconsistencies at the graph level without requiring assumptions about hardware, ranging mechanisms, or cryptographic protocols. We give necessary conditions for which attack detection is guaranteed to be successful in the noiseless case, and we use that intuition to extend G
ordian
to the noisy case where fewer guarantees are possible. In simulations generated from real-world sensor noise, we empirically show that G
ordian
’s trilateration counterexample generation procedure enables rapid attack detection even for combinatorially difficult problems.
Pattern-based Interactive Configuration Derivation for Cyber-physical System Product Lines
Authors: Lu Hong , Yue Tao , Ali Shaukat
Published: June 2020

Deriving a Cyber-Physical System (CPS) product from a product line requires configuring hundreds to thousands of configurable parameters of components and devices from multiple domains, e.g., computing, control, and communication. A fully automated configuration process for a CPS product line is seldom possible in practice, and a dynamic and interactive process is expected. Therefore, some configurable parameters are to be configured manually, and the rest can be configured either automatically or manually, depending on pre-defined constraints, the order of configuration steps, and previous configuration data in such a dynamic and interactive configuration process. In this article, we propose a pattern-based, interactive configuration derivation methodology (named as Pi-CD) to maximize opportunities of automatically deriving correct configurations of CPSs by benefiting from pre-defined constraints and configuration data of previous configuration steps. Pi-CD requires architectures of CPS product lines modeled with Unified Modeling Language extended with four types of variabilities, along with constraints specified in Object Constraint Language (OCL). Pi-CD is equipped with 324 configuration derivation patterns that we defined by systematically analyzing the OCL constructs and semantics. We evaluated Pi-CD by configuring 20 CPS products of varying complexity from two real-world CPS product lines. Results show that Pi-CD can achieve up to 72% automation degree with a negligible time cost. Moreover, its time performance remains stable with the increase in the number of configuration parameters as well as constraints.
MC-Safe
Authors: Bai Yunhao , Zheng Kuangyu , Wang Zejiang , Wang Xiaorui , Wang Junmin
Published: June 2020

In a Vehicular Cyber Physical System (VCPS), ensuring the real-time delivery of safety messages is an important research problem for Vehicle to Vehicle (V2V) communication. Unfortunately, existing work relies only on one or two pre-selected control channels for safety message communication, which can result in poor packet delivery and potential accident when the vehicle density is high. If all the available channels can be dynamically utilized when the control channel is having severe contention, then safety messages can have a much better chance to meet their real-time deadlines.

In this article, we propose MC-Safe, a multi-channel V2V communication framework that monitors all the available channels and dynamically selects the best one for safety message transmission. During normal driving, MC-Safe monitors periodic beacons sent by other vehicles and estimates the communication delay on all the channels. Upon the detection of a potential accident, MC-Safe leverages a novel channel negotiation scheme that allows all the involved vehicles to work collaboratively, in a distributed manner, for identifying a communication channel that meets the delay requirement. MC-safe also features a novel coordinator selection algorithm that minimizes the delay of channel negotiation. Once a channel is selected, all the involved vehicles switch to the same selected channel for real-time communication with the least amount of interference. Our evaluation results both in simulation and on a hardware testbed with scaled cars show that MC-Safe outperforms existing single-channel solutions and other well-designed multi-channel baselines by having a 23.4% lower packet delay on average compared with other well-designed channel selection baselines.
A Glimpse into the Past, Present, and Future of Engineering Interactive Computing Systems
Authors: Bowen Judy , Winckler Marco , Vanderdonckt Jean
Published: June 2020

The area of Engineering Interactive Computing Systems (EICS) is defined as the intersection between Software Engineering (SE) and Human-Computer Interaction (HCI). In this paper, we provide an overview of what EICS is and how it is positioned with respect to other venues in HCI, such as CHI, UIST, and IUI, highlighting its legacy and paying homage to past scientific events from which EICS emerged. We also take this opportunity to deliver a comparative analysis of the past, present, and perhaps future research and development questions raised in EICS by analyzing the EICS papers published from its first edition to this one, based on global and chronological word clouds, phrase nets, and topic modelling.
LanguageLogger: A Mobile Keyboard Application for Studying Language Use in Everyday Text Communication in the Wild
Authors: Bemmann Florian , Buschek Daniel
Published: June 2020

We present a concept and tool for studying language use in everyday mobile text communication (e.g. chats). Our approach for the first time enables researchers to collect comprehensive data on language use during unconstrained natural typing (i.e. no study tasks) without logging readable messages to preserve privacy. We achieve this with a combination of three customisable text abstraction methods that run directly on participants' phones. We report on our implementation as an Android keyboard app and two evaluations: First, we simulate text reconstruction attempts on a large text corpus to inform conditions for minimising privacy risks. Second, we assess people's experiences in a two-week field deployment (N=20). We release our app as an open source project to the community to facilitate research on open questions in HCI, Linguistics and Psychology. We conclude with concrete ideas for future studies in these areas.
Strategic paddling
Authors: Shasha Dennis
Published: June 2020

Choosing how to best navigate turbulent current events.
Call for a wake standard for artificial intelligence
Authors: Subirana Brian
Published: June 2020

Suggesting a Voice Name System (VNS) to talk to any object in the world.
Balance between oxygen transport and blood rheology during resuscitation from hemorrhagic shock with polymerized bovine hemoglobin
Authors: Williams Alexander T. , Lucas Alfredo , Muller Cynthia R. , Bolden-Rush Crystal , Palmer Andre F. , Cabrales Pedro
Published: June 2020

Large-molecular diameter polymerized bovine hemoglobin avoided vasoconstriction and impairment of cardiac function during resuscitation from hemorrhagic shock that was seen with previous hemoglobin-based O2 carriers by increasing blood viscosity in a concentration-dependent manner. Supplementation of O2-carrying capacity played a smaller role in maintaining cardiac function than increased blood and plasma viscosity.
Effects and Mechanisms of Five Psoralea Prenylflavonoids on Aging-Related Diseases
Authors: Zhou Yi-Ting , Zhu Lin , Yuan Yunyun , Ling Shuang , Xu Jin-Wen
Published: June 2020

During the aging process, senescent cells gradually accumulate in the organs; they secrete proinflammatory cytokines and other factors, collectively known as the senescence-associated secretory phenotype (SASP). SASP secretions contribute to “inflammaging,” which is a state of chronic, systemic, sterility, low-grade inflammatory microenvironment and a key risk factor in the development of aging-related diseases. Fructus psoraleae is a traditional Chinese medical herb best known for delaying aging and treating osteoporosis. Prenylflavonoids from fructus psoraleae are the main bioactive compounds responsible for its pharmacological applications, such as beaching, bavachinin, bavachalcone, isobavachalcone, and neobavaisoflavone. In previous decades, there have been some promising studies on the pharmacology of fructus psoraleae. Here, we focus on the anti-inflammatory and antiaging diseases of five psoralea prenylflavonoids, such as cardiovascular protection, diabetes and obesity intervention, neuroprotection, and osteoporosis, and discuss the mechanism of these active ingredients for better understanding the material basis and drug application of fructus psoraleae in Chinese medicine.
The Mechanism of Metabolic Influences on the Endogenous GLP-1 by Oral Antidiabetic Medications in Type 2 Diabetes Mellitus
Authors: Nguyen Thiquynhnga , Gong Min , Wen Song , Yuan Xinlu , Wang Chaoxun , Jin Jianlan , Zhou Ligang
Published: June 2020

Incretin-based therapy is now a prevalent treatment option for patients with type 2 diabetes mellitus (T2DM). It has been associated with considerably good results in the management of hyperglycemia with cardiac or nephron-benefits. For this reason, it is recommended for individuals with cardiovascular diseases in many clinical guidelines. As an incretin hormone, glucagon-like peptide-1 (GLP-1) possesses multiple metabolic benefits such as optimizing energy usage, maintaining body weight, β cell preservation, and suppressing neurodegeneration. However, recent studies indicate that oral antidiabetic medications interact with endogenous or exogenous GLP-1. Since these drugs are transported to distal intestine portions, there are concerns whether these oral drugs directly stimulate intestinal L cells which release GLP-1, or whether they do so via indirect inhibition of the activity of dipeptidyl peptidase-IV (DPP-IV). In this review, we discuss the metabolic relationships between oral antihyperglycemic drugs from the aspect of gut, microbiota, hormones, β cell function, central nervous system, and other cellular mechanisms.
Development and Verification of the Diagnostic Model of the Sieving Screen
Authors: Krot Pavlo , Zimroz Radoslaw , Michalak Anna , Wodecki Jacek , Ogonowski Szymon , Drozda Michal , Jach Marek
Published: June 2020

The minerals processing enterprises are widely using vibrating machines to separate different fractions of materials. Sieving efficiency is greatly dependent on particle trajectories, or orbit, of periodical motion over the sieving decks. A screening process is very dependable on design parameters such as the vibrator power, synchronisation of their drives, and oscillation frequency as well as the stiffness of supporting springs. Deterioration of supporting springs (stiffness reduction and cracks) due to cyclic loading and fatigue is difficult to determine by the visual inspection, static loading tests, or nondestructive testing techniques. Vibration monitoring systems of different vendors are analysed where vibration sensors usually installed on the bearings of vibrators are as well used for supporting springs diagnostics. However, strong cyclic components from the unbalanced exciters and stochastic disturbances from the input stream and vibrating pieces of the material make analysis a not trivial task. The considered vibrating screen is investigated on the 6-DOF (degree-of-freedom) dynamical model to reflect all linear and rotational components of spatial motion. Besides the main periodic motion, the model accounts for stochastic alpha-stable distributed impacts from the material. Instead, the Gaussian normal distribution is considered for the position of equivalent force application point. Supporting springs are represented by the bilinear stiffness characteristics. Specific features of vibration signals (angle of orbit inclination, natural frequency change, harmonics of natural frequency, and phase space plots) are analysed to recognise the weak nonlinear features of a system under conditions of small stiffness changes in springs. The extensive measurements are conducted on the industrial vibrating screen, and the dynamic model is verified by the measurement data. Recommendations are given on failure diagnostics of springs in the industrial vibrating screens.
Open-label, Phase I Study of Nivolumab Combined with nab-Paclitaxel Plus Gemcitabine in Advanced Pancreatic Cancer
Authors: Wainberg Zev A. , Hochster Howard S. , Kim Edward J. , George Ben , Kaylan Aparna , Chiorean E. Gabriela , Waterhouse David M. , Guiterrez Martin , Parikh Aparna , Jain Rishi , Carrizosa Daniel Ricardo , Soliman Hatem H. , Lila Thomas , Reiss David J. , Pierce Daniel W. , Bhore Rafia , Banerjee Sibabrata , Lyons Larry , Louis Chrystal U. , Ong Teng Jin , O'Dwyer Peter J.
Published: June 2020

Purpose:

Assess safety and efficacy of nivolumab plus nab-paclitaxel and gemcitabine in patients with locally advanced/metastatic pancreatic cancer in a two-part, open-label, phase I trial.

Patients and Methods:

Fifty chemotherapy-naive patients received nab-paclitaxel 125 mg/m2 plus gemcitabine 1,000 mg/m2 (days 1, 8, and 15) and nivolumab 3 mg/kg (days 1 and 15) in 28-day cycles. The primary endpoints were dose-limiting toxicities (DLTs; part 1) and grade 3/4 treatment-emergent adverse events (TEAEs) or treatment discontinuation due to TEAEs (parts 1/2). Secondary efficacy endpoints were progression-free survival (PFS), overall survival (OS), and response. Assessment of programmed cell death-ligand 1 (PD-L1) expression was an exploratory endpoint; additional biomarkers were assessed post hoc.

Results:

One DLT (hepatitis) was reported in part 1 among six DLT-evaluable patients; 48 of 50 patients experienced grade 3/4 TEAEs and 18 discontinued treatment due to TEAEs. One grade 5 TEAE (respiratory failure) was reported. Median [95% confidence interval (CI)] PFS/OS was 5.5 (3.25–7.20 months)/9.9 (6.74–12.16 months) months, respectively [median follow-up for OS, 13.6 months (95% CI, 12.06–23.49 months)]. Overall response rate (95% CI) was 18% (8.6%–31.4%). Median PFS/OS was 5.5/9.7 months (PD-L1 <5%) and 6.8/11.6 months (PD-L1 ≥5%), respectively. Proportion of peripheral Ki67+ CD8+/CD4+ cells increased significantly from baseline to cycle 3; median peak on-treatment Ki67+ CD8+ T-cell values were higher in responders than in nonresponders.

Conclusions:

The safety profile of nivolumab plus nab-paclitaxel and gemcitabine at standard doses in advanced pancreatic cancer was manageable, with no unexpected safety signals. Overall, the clinical results of this study do not support further investigation.
Neuronal Surface Antibody Syndrome: A Review of the Characteristics of the Disease and Its Association with Autoantibodies
Authors: Liu Rui , Zhang Mingkai , Liu Lingling , Chen Gang , Hou Yiwei , Wang Meiling , Li Jianmin
Published: June 2020

Several studies have certified that autoantibodies play an important role in the manifestation of neuromuscular diseases. Scientists have discovered specific neuronal tumor antibodies in patients with typical paraneoplastic neurological disorders. But in some clinical cases, it is not useful to cure this disease with common treatments unless the autoantibodies are addressed. In addition, recent studies have shown a close relationship between certain antibodies and neuronal surface proteins in some special cases. These antibodies, which act on the surface of neurons, mainly include voltage-gated calcium channel (VGKC) antibodies. VGKC antibodies are further divided into several types including anti-leucine-rich glioma inactivated 1 (LGI1), anti-contactin-associated protein-like 2 (Caspr2), anti-N-methyl-D-aspartate receptor (NMDAR), anti-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR), anti-γ-aminobutyric acid receptor (GABAR), and glycine receptor. For the purpose of this review, cases of clinical studies of autoantibody-associated encephalitis were collected, the key points regarding the pathogenesis were summarized, the clinical manifestation was discussed, and all this information was organized as this review in order to introduce the relationship between autoantibodies and autoimmune encephalitis. Furthermore, it is hoped that it can effectively direct the development of diagnostic and therapeutic approach in the future.
Critical and Sensitive Periods in Development and Nutrition
Authors: Colombo John , Gustafson Kathleen M. , Carlson Susan E.
Published: June 2020

Critical or sensitive periods in the life of an organism during which certain experiences or conditions may exert disproportionate influence (either for harm or benefit) on long-term developmental outcomes have been the subject of investigation for over a century. This chapter reviews research in the context of the development of social preferences and sensory systems, with a summary of the criteria for defining such a period and the evidence necessary to establish its existence. The notion of nutritional programming, central to the Barker/Developmental Origins hypotheses of health and disease, represents a variant of the critical/sensitive period concept. It is implicit in these hypotheses that the fetal period is a time during which metabolic and physiological systems are malleable and thus susceptible to either insult or enhancement by nutrient intake. Evidence for critical/sensitive periods or nutritional programming requires a systematic manipulation of the age at which nutritional conditions or supplements are implemented. While common in research using animal models, the approach is difficult to establish in epidemiological studies and virtually nonexistent in human clinical trials. Future work seeking to establish definitive evidence for critical/sensitive periods or programming may be advanced by harmonized outcome measures in experimental trials across which the timing, duration, and dose of nutrients is varied.
True power loss reduction by augmented mine blast algorithm
Authors: Lenin Kanagasabai
Published: June 2020

In this paper, Mine Blast Algorithm (MBA) has been intermingled with Harmony Search (HS) algorithm for solving optimal reactive power dispatch problem. MBA is based on explosion of landmines and HS is based on Creativeness progression of musicians – both are hybridized to solve the problem.  In MBA Initial distance of shrapnel pieces are reduced gradually to allow the mine bombs search the probable global minimum location in order to amplify the global explore capability. Harmony search (HS) imitates the music creativity process where the musicians supervise their instruments’ pitch by searching for a best state of harmony. Hybridization of Mine Blast Algorithm with Harmony Search algorithm (MH) improves the search effectively in the solution space. Mine blast algorithm improves the exploration and harmony search algorithm augments the exploitation. At first the proposed algorithm starts with exploration & gradually it moves to the phase of exploitation. Proposed Hybridized Mine Blast Algorithm with Harmony Search algorithm (MH) has been tested on standard IEEE 14, 300 bus test systems. Real power loss has been reduced considerably by the proposed algorithm. Then Hybridized Mine Blast Algorithm with Harmony Search algorithm (MH) tested in IEEE 30, bus system (with considering voltage stability index)- real power loss minimization, voltage deviation minimization, and voltage stability index enhancement has been attained.
Electronic doorbell system using keypad and GSM
Authors: Simon O. A. , Bature U. I. , Jahun K. I. , Tahir N. M.
Published: June 2020

In our homes or offices, security has been a vital issue. Control of home security system remotely always offers huge advantages like the arming or disarming of the alarms, video monitoring, and energy management control apart from safeguarding the home free up intruders. Considering the oldest simple methods of security that is the mechanical lock system that has a key as the authentication element, then an upgrade to a universal type, and now unique codes for the lock. The recent advancement in the communication system has brought the tremendous application of communication gadgets into our various areas of life. This work is a real-time smart doorbell notification system for home Security as opposes of the traditional security methods, it is composed of the doorbell interfaced with GSM Module, a GSM module would be triggered to send an SMS to the house owner by pressing the doorbell, the owner will respond to the guest by pressing a button to open the door, otherwise, a message would be displayed to the guest for appropriate action. Then, the keypad is provided for an authorized person for the provision of password for door unlocking, if multiple wrong password attempts were made to unlock, a message of burglary attempt would be sent to the house owner for prompt action. The main benefit of this system is the uniqueness of the incorporation of the password and messaging systems which denies access to any unauthorized personality and owner's awareness method.
Resenha de Antonio Candido 100 anos
Authors: Moraes Anita Martins Rodrigues de
Published: June 2020

Resenha: FONSECA, Maria Augusta; SCHWARZ, Roberto (orgs.). Antonio Candido 100 anos. São Paulo: Editora 34, 2018 (496 p.).
D'a Espírita e de Encostando no barranco, para cândida apreciação
Authors: Moreschi Marcelo
Published: June 2020

Breve relato das intervenções "A Espírita do Ocidente em busca de nova morada" e de "Encostando no barranco", do Grupo de Estudos da Deriva.
questão do primitivismo e a representação dos povos indígenas em Antonio Candido
Authors: Cardoso Rodrigo Octávio
Published: June 2020

Este artigo analisa os usos dos termos primitivo e primitivismo em diversos textos de Antonio Candido, dos anos 1950 aos anos 1980, em sua relação com os povos indígenas do Brasil. Nesses textos, os termos assumem um caráter polissêmico e instável que será comentado, apresentando reflexões teóricas sobre seu significado para o pensamento do ocidente e para a compreensão da arte moderna. O artigo busca, dessa forma, explicitar pressupostos teóricos e ideológicos que estruturam a obra do crítico e sua concepção ampla da cultura brasileira, em sua relação histórica com os povos indígenas do Brasil.
Inflammasomes and Proteostasis Novel Molecular Mechanisms Associated With Atrial Fibrillation
Authors: Li Na , Brundel Bianca J.J.M.
Published: June 2020

Atrial fibrillation (AF), the most common progressive and age-related cardiac arrhythmia, affects millions of people worldwide. AF is associated with common risk factors, including hypertension, diabetes mellitus, and obesity, and serious complications such as stroke and heart failure. Notably, AF is progressive in nature, and because current treatment options are mainly symptomatic, they have only a moderate effect on prevention of arrhythmia progression. Hereto, there is an urgent unmet need to develop mechanistic treatments directed at root causes of AF. Recent research findings indicate a key role for inflammasomes and derailed proteostasis as root causes of AF. Here, we elaborate on the molecular mechanisms of these 2 emerging key pathways driving the pathogenesis of AF. First the role of NLRP3 (NACHT, LRR, and PYD domains-containing protein 3) inflammasome on AF pathogenesis and cardiomyocyte remodeling is discussed. Then we highlight pathways of proteostasis derailment, including exhaustion of cardioprotective heat shock proteins, disruption of cytoskeletal proteins via histone deacetylases, and the recently discovered DNA damage-induced nicotinamide adenine dinucleotide
+
depletion to underlie AF. Moreover, potential interactions between the inflammasomes and proteostasis pathways are discussed and possible therapeutic targets within these pathways indicated.
Integrative taxonomy of the willow cyst nematode, Heterodera salixophila Kirjanova, 1969, a new record of the Humuli group from Iran
Authors: Rezaee Danesh Younes , Mokaram Hesar Abbas , Ghaderi Reza
Published: June 2020

Whilst investigating plant-parasitic nematodes in Urmia City, West Azerbaijan, Iran, soil samples were collected from the rhizosphere of willow trees (Salix babylonica) known to have a population of cyst nematodes. Morphological, numerical and molecular approaches revealed that this population represented the willow cyst nematode, Heterodera salixophila, the first report of this species from Iran. Reproduction of the nematode on S. babylonica was confirmed by inoculating 5000 viable eggs and second-stage juveniles (J2) per kg soil on 2-year-old seedlings of S. babylonica grown in pots containing sterilised soil and incubated under glasshouse conditions. Principal Component Analysis (PCA) and hierarchical cluster analysis of morphometric characters of J2 and vulval plates of species within the Humuli group supported the separation of H. salixophila from other species in this group. In the ITS-rRNA phylogenetic tree, the Iranian population of H. salixophila formed a cluster with two other populations of the species from Belgium and Ukraine, while in the D2-D3 expansion segments of the 28S rRNA tree, it grouped with a population from Belgium as a basal clade in the Humuli group.
Bimuria omanensis sp. nov. (Didymosphaeriaceae, Pleosporales) from Oman

Authors: WIJESINGHE SUBODINI N. , WANASINGHE DHANUSHKA N. , MAHARACHCHIKUMBURA SAJEEWA S. N. , WANG YONG , AL-SADI ABDULLAH M. , HYDE KEVIN D.
Published: June 2020

Bimuria is a monotypic genus in Didymosphaeriaceae, typified by B. novae-zelandiae collected in terrestrial habitats from New Zealand soil. In our study, Bimuria omanensis, a novel species was isolated from unidentified decaying leaves in Oman. The phylogenetic placement of B. omanensis is resolved based on maximum likelihood, maximum parsimony and Bayesian analyses of combined LSU, ITS and TEF1-α sequence data of Didymosphaeriaceae. The placement of Bimuria omanensis as a distinct species, is confirmed based on phylogeny. This is the first record of an asexual morph in Bimuria and first record of a Bimuria species from Oman. The relationship of this taxon with other phylogenetically closely related Didymosphaeriaceae species is shown.
Austronea phyllopogon (Hyacinthaceae, Urgineoideae), a new species from the Kamiesberg, Northern Cape Province in South Africa

Authors: MARTÍNEZ-AZORÍN MARIO , PINTER MICHAEL , CRESPO MANUEL B. , ALONSO-VARGAS MARÍA ÁNGELES
Published: June 2020

Among the recently described genera in Hyacinthaceae subfamily Urgineoideae (= Asparagaceae subfam. Scilloideae tribe Urgineeae), Austronea Mart.-Azorín, M.B.Crespo, M.Pinter & Wetschnig in Martínez-Azorín et al. (2018: 105) includes 20 species restricted to southern Africa (Martínez-Azorín et al. 2018, 2019a, 2019b). Some such species were traditionally included in Urginea Steinheil (1834: 321) or Drimia Jacq. ex Willdenow (1799: 165) sensu lato and resemble those of Fusifilum Rafinesque (1837: 27), a phylogenetic relationship supported by molecular data (Martínez-Azorín et al. in prep.). However, species of Austronea are easily identified by a unique syndrome of morphological characters, the most characteristic being the subcorymbose or congested raceme that commonly nods during early developmental stages, the green to yellowish ovary (in contrast to the white gynoecium of Fusifilum) and the tetrahedrally folded seeds with narrowly winged angles (see Martínez-Azorín et al. 2018).
Saprobic Dothideomycetes in Thailand: Phaeoseptum hydei sp. nov., a new terrestrial ascomycete in Phaeoseptaceae

Authors: WANASINGHE DHANUSHKA N. , MORTIMER PETER E. , SENWANNA CHANOKNED , CHEEWANGKOON RATCHADAWAN
Published: June 2020

During a survey of saprobic microfungi in Thailand, a dothideomycetous fungus was found on a dead twig of Delonix regia, on the Chiang Mai University campus. This fungus is characterized by fully immersed ascomata under a small blackened pseudoclypeus, pseudoparenchymatous peridium, cellular pseudoparaphyses, cylindrical-clavate asci with a distinct pedicel, overlapping 3–4-seriate, pale to dark brown, broadly fusoid, 7–9-transversally septate ascospores with a vertical septum in nearly all median cells. Multigene phylogenetic analyses, using partial sequences from the 28S nrRNA gene (LSU), 18S nrRNA gene (SSU), internal transcribed spacer regions and intervening 5.8S nrRNA gene (ITS) of the nrDNA operon and the translation elongation factor 1-alpha region (TEF) demonstrated a monophyletic affiliation of the new strain, accommodating the species of Phaeoseptum in the family Phaeoseptaceae. With further morphological and phylogenetic investigations, we justify the new fungus as a novel species, Phaeoseptum hydei in Phaeoseptaceae. Detailed descriptions and illustrations are provided for Phaeoseptum hydei and this novel species compared with the remaining species found in the genus. An updated checklist of microfungi recorded on Delonix regia from around the world is also provided.
Discovery of isolated leaves of Marskea (Taxaceae) in the Middle Jurassic sediments of Irkutsk Basin (East Siberia, Russia)

Authors: FROLOV ANDREY O. , MASHCHUK IRINA M.
Published: June 2020

Study of isolated leaf compressions from Prisayan Formation outcrops on the right side of the Irkutsk reservoir resulted in identification of a new species: Marskea cuspidata sp. nov. The species has a strong morphological affinity with M. heeriana N. Nosova et Kiritchkova and T. ketovae Teslenko. The epidermis original texture differs well the Marskea cuspidata sp. nov. from other representatives of the genus Marskea which are known from the Jurassic and Lower Cretaceous sediments of Europe, Central Asia and Siberia.
Tupistra nganii (Asparagaceae), a new species with greenish yellow flowers from northern Vietnam and southwestern China

Authors: AVERYANOV LEONID V. , NGUYEN KHANG SINH , NURALIEV MAXIM S. , VISLOBOKOV NIKOLAY A. , ТANAKA NORIYUKI , KOPYLOV-GUSKOV YURY O. , LYSKOV DMITRY F. , MAISAK TATIANA V. , HIEU NGUYEN QUANG , KUZNETSOV ANDREY N. , KUZNETSOVA SVETLANA P. , THAI TRAN HUY
Published: June 2020

Tupistra nganii is described and illustrated as a new species from Ha Giang Province in northern Vietnam and Yunnan Province in southwestern China. The new species is most similar to T. muricata from Thailand and Laos, from which it differs by the greenish white or yellow perianth and longer exserted stamens. Additionally, Tupistra longispica is reinstated on the basis of new morphological evidences.
Nigrospora guangdongensis sp. nov. from the needle of Cunninghamia lanceolata in China

Authors: TIAN LONG-YAN , ZHANG YAN-FENG , LIAN TAO , QIN CHANG-SHENG , XU JIN-ZHU
Published: June 2020

Nigrospora is a genus occurring on various substrates as pathogens, saprophytes or endophytes. In this study, Nigrospora strains were isolated from the needles of Cunninghamia lanceolata in Guangdong province of China. According to the morphological and phylogenetic evidence, it can be recognized as a new species. Hereby, Nigrospora guangdongensis sp. nov. is introduced and it can be distinguished from its phylogenetically close species, by having sparse, discrete, and solitary conidiophores with sporadic conidia.