bluuebunny/crossref_metadata_2025 huggingface dataset:
Enriched Biscuits of Ficus Capensis Modulates Neurobehavioral Performance and Antioxidant Status of L-NAME Induced Hypertensive Rats with Anxiety-Like Behaviour
Authors: Ajeigbe Olufunke Florence , Oboh Ganiyu , Ademosun Ayokunle Olubode
Published: October 2023

Purpose - Anxiety and cognitive deterioration in hypertensive patients are underreported in hypertensive state. This study investigated the neuroprotective effect of Ficus capensis (FC) on cognition and anxiety-like behaviors in L-NAME-induced hypertensive male rats.
Method - Rats were administered 40 mg/kg/day L-NAME and treated with atenolol (10 mg/kg/day), diazepam (5 mg/kg/day), 2.5 g, and 5.0 g FC-enriched biscuits, respectively, (n=8) per group for 21 consecutive days. Locomotor behavior was monitored using video-tracking software for open-field tests, elevated plus maze tests, and light and dark tests, and blood pressure was measured with non-invasive tail-cuff motoring. Furthermore, acetylcholinesterase (AChE), butyl-cholinesterase (BChE), antioxidant enzyme activities in the hypothalamic and medulla brain regions, and histological staining in the hypothalamic brain section were deduced.
Results - findings from this study indicated that treatment of L-NAME-induced hypertensive rats with FC significantly (p < 0.05) ameliorated cognitive deficits and anxiety-like behavior, specifically by decreasing cumulative immobility duration in open field, rearing, latency time, and number in the dark and increasing latency time and number in the light in light and dark boxes, and zonal alterations in elevated plus maze. Additionally, FC assuaged the L-NAME-induced decrease in brain antioxidant enzyme activities and increased AChE and BChE activity and lipid peroxidation levels in the hypothalamus and medulla of hypertensive rats.
Conclusion - Taken together, FC revealed its role in reducing L-NAME-induced cognitive decline and anxiety-like behavior in hypertensive rats to be linked to its ability to restore cholinesterase enzyme activity and augment redox status. However, FC had no effect on the brain structure of L-NAME hypertensive rats.
Priority-Based Genetic Algorithm for theClustered Steiner Tree Problem
Authors: Do Tuan-Anh , Ban Ha-Bang , Le Minh Tu , Phan Duc Hung , Nguyen Thai Ha , Huynh Thi Thanh Binh
Published: October 2023

In a complex network connecting many devices, a set of nodes might be partitioned into multiple local clusters with different functions, properties, or communication protocols. Thus, there has been a rise in network design problems with additional constraints regarding the clustering of vertices, one of them being the Clustered Steiner Tree Problem - a variant of the Steiner Tree Problem. In the literature, there have been a few research working on this problem, but either they only solve it in a metric case, or their exploration capability is still limited. Therefore, their results are not actually good in many cases. To overcome the drawbacks, we propose a Priority-Based Genetic Algorithm to solve the Clustered Steiner Tree Problem. The proposed algorithm maintains a balance between exploration and exploitation to prevent the search from local optima. Experiments and comparisons to existing works in non-metric and metric cases are carried out deliberately to prove the remarkable performance of the proposed algorithm.
Impact of (Wood Particles (Reed) / Polypropylene) Composites on the Physical and Structural Properties
Authors: ali Raya
Published: October 2023

The present research focuses on the preparation of Polypropylene resin/Wood particle (reed) Composites and the study of the influence of adding the residues of natural materials on the physical and structural properties of the composite. (Polypropylene resin/Wood particle (reed) Composite has been prepared by extruding method with weight fraction (30) % and treated (reed) by sodium chloride solution (0.5). physical and structural properties which include bulk density and absorbance rate are investigated for (pure p.p), (p.p + w), (p.p.+w + silan coupling agent), (p.p.+w + Mgo),(p.p. + w + Zn(C18H35O2)2, the results illustrate enhancing in the bulk density for all samples with adding wood particles also with adding silane coupling agent, Magnesium oxide, and zinc stearate, where the maximum value of bulk density rate was for (pp + w + Mgo) composite. absorbance test was investigated by Immersion in Distilled water and Immersion in the chemical solution for all composites, the results illustrate. The weight gain of the samples after immersion is increasing compared with the sample before immersion.. AFM (Atomic Force Microscopic) for all samples was tested. It is obvious from the Topographical picture that the roughness value of wood particles reinforced polypropylene composite was high. These results indicate the features of plastic wood composites, where consider better than natural wood in terms of durability and strength of the material.
Exploring the mechanism of Chang-An-Kang on active ulcerative colitis rats based on NF-κB/STAT3 signaling pathway
Authors: Lu Zhenhua
Published: October 2023

Objective To investigate the therapeutic effect and mechanism of Chang-An-Kang on ulcerative colitis rats.
MethodsThe rat model of ulcerative colitis induced by 6% glacial acetic acid was established. The corresponding therapeutic drugs were given 24 hours after the model was established. The pathological morphology of colon tissue were observed after 21 days of continuous administration. The levels of interleukin-6 (IL-6) , Interleukin-7 (IL-7) , interleukin-10 (IL-10) and tumor necrosis factor alpha (TNF-α) were measured by ELISA kit. The expression levels of NF-κBand STAT3 proteins in colon tissue were detected by IHC.
ResultsThe results showed that the changes of the pathological and biochemical indexes of the rat colon tissue indicate that the model was successfully established. Chang-An-Kang could significantly improved the rat colon tissue damage, decrease the content of IL-6, IL-7 and TNF-α, and increase the content of Il-10. The NF-κB and STAT3 proteins expression levels were decreased.
Conclusion By increasing the content of anti-inflammatory factor IL-10, decreasing the content of pro-inflammatory factors IL-6 and TNF-α, and inhibiting the expression of NF-κB and STAT3 proteins, Chang-An-Kangcan reduce inflammatory infiltration. It has a obvious therapeutic effect on acetic acid ulcerative colitis in rats.
Weight development in a northern island population of water voles Arvicola amphibius: approaching an optimal weight to survive the winter?
Authors: Frafjord Karl
Published: October 2023

Abstract
Background: Growth and body size of mammals are commonly correlated with many life history strategies, including those related to survival and reproduction. However, in certain circumstances suboptimal growth rates and smaller size may be advantageous and adaptive. The water vole Arvicola amphibius is a large vole, about three times the size of a field vole Microtus agrestis, but with similar ecological and reproductive characteristics. Island populations were studied on the coast of northern Norway, just below the Arctic Circle, during 2003-2018, by capture-mark-recapture. The main aims were to study growth rates, asymptotic weight and survival, expecting that the “optimal” weight for surviving the winter would be 140-160 g.
Results: The smallest juveniles caught weighed only 21 g and were assumed, based on data from the literature, to be around 14 days old. This age was used as starting point for the growth curve. This, however, may have been about one week too early, as juveniles are more likely not fully weaned and leave their nest of birth until 30-40 g. Initial growth rates in juveniles was relatively high but declined from around 100-120 g or 40-50 days old. The asymptotic weight was not clearly defined, but its maximum was around 150-160 g. Most juveniles that survived the winter weighed between 100 and 160 g in their first summer. Large individual variations in growth rates were found. Overwintered subadults in spring weighed about the same as juveniles did in the autumn but grew quickly in April and May to reach adult size.
Conclusions: A specific “optimal” weight for juveniles that survived the winter was not found. The range could be given as 100-160 g, too broad to define an “optimal” weight range. However, those that survived tended to be slightly heavier than those that died. Reproducing adults generally weighed 180-220 g and did not reduce their weight toward the autumn, i.e., to increase winter survival, but very few adults survived even the summer and almost none survived their second winter. Juveniles postponed reproduction until next spring, most likely to take advantage of fresh vegetation growth and less competition.
Fast Improvements of Acute Inflammatory Symptomatology in Patients With Hand Osteoarthritis With the Use of Doxycycline.
Authors: DE AZEVEDO MARIO NEWTON LEITAO , Arnez Marco Antonio Cullar , Moss Ingrid Bandeira , Bianchi Breno Valdetaro , Bica Blance Elena Rios Gomes
Published: October 2023

Background: Osteoarthritis (OA) presents the high activity of free radicals and proteolytic enzymes which were inhibited by Doxycycline (DOX).
Objective: To search the efficacy, safety, and fastness for the improvement of inflammatory signs in patients with Hand Osteoarthritis (HOA).
Methodology: Randomized, placebo-controlled trial during four weeks with two groups of patients: DOX group using one tablet of 100 mg bid per os; control group using paracetamol bid per os; the data were obtained through Visual Analog Scale (VAS) evaluation for pain, flushing/edema by the patient and the examiner; the primary outcome was the improvement greater than 50% from the basal values after four weeks.
Results: Thirty-eight female patients with HOA after menopause were allocated: 20 in the DOX group and 18 in the control group. The results showed that the DOX group presented a significant improvement in 75% of patients compared to the control group (p <0.00000), which started after 6.05 ± 3.7 days of treatment; and mild adverse effects in 20% of the sample - gastric pain, nausea, vomiting after 9.0 ± 5.2 days without any removal from the trial. Compared to the baseline and the control group results, was observed a significant improvement in pain (p <0.00000) and edema/flushing (p<0.00000) demonstrated the efficacy of inflammation; no abnormality was seen on the blood analysis, and no hematological, renal, cardiologic and hepatic commitment.
Conclusion: Doxycycline by a short length of time was safe and improved the pain and inflammatory signs of HOA.
The Use of the Mobile Phone for Real-Time Notifications of Public Health Threats in Three Mali Health Districts between 2020-2021
Authors: Kafflouman Kouamé Stanislas
Published: October 2023

The Ministry in charge of Health in Mali has decided to involve the community in the fight against public health threats using mobile phones according to WHO guidelines. In this regard, a guide and standard tools for community-based electronic surveillance have been developed and tested in a pilot phase in the Kadiolo health district. After the training of the actors (community health workers “ASC”, health workers and epidemiological surveillance officers), all were equipped with telephony and data collection tools. To this end, CHWs send a coded message to health centers and districts every day. Then these messages are confirmed or invalidated by health workers through an investigation and the taking of samples for transport to the lab. The number of cases notified by CHWs via the electronic system was 1397 cases in 444 days, with 170 cases of illnesses and 1227 cases of events. This electronic early warning system enabled the notification of cases in less than 24 hours at the higher level. Also, the completeness of sending messages by district varied between [71 and 83%] and the cumulative average completeness of the three districts was around 77%. On average 72% of CHWs sent at least one message with a notification of 3.14 cases of illnesses and events per day. Mobile telephone is a suitable and less expensive means for the notification of diseases and events in real time. Keywords: Community health workers, Events, Diseases, Real-time notification, Mobile telephony, Community-based electronic surveillance.
The Impacts of Antiretroviral and Antifungal Treatments, and Tuberculosis Co-infection on Mortality and Relapse in Patients with Talaromyces Marneffei Infection
Authors: Tat Thanh Nguyen
Published: October 2023

To date, clinical data on long-term clinical outcomes, including 6-month mortality and relapse in talaromycosis (Tm) patients and impacts of ART and secondary antifungal prophylaxis are still lacking. We conducted a secondary data analysis from 6-month prospective observation of patients with culture-confirmed talaromycosis who participated in the Itraconazole versus Amphotericin B for HIV-associated Talaromycosis (IVAP) trial. The primary outcome was 6-month Tm mortality, while the secondary outcome was relapse. Multivariable Cox proportional hazard models were used to identify predictors of outcomes of interest. The median patient age was 34 years (IQR:30 – 38). The median pre-ART CD4 counts at baseline were 10 (IQR: 5-21) cells/µL. The cumulative 76/435 (17.4%) patients died, and Tm relapse was observed in 18/435 (4.1%) patients. The multivariable analyses showed that strong independent predictors of 6-month Tm mortality included ineffective ART (either absence of ART or ART failure) (HR = 6.26, 95% CI: 3.95 – 9.92, P < 0.001), and TB co-infection (HR =1.98, 95% CI: 1.23 – 3.17; P < 0.01). Induction antifungal treatment with itraconazole versus amphotericin B deoxycholate was significantly associated with Tm death in the univariable model, however, it became insignificant in the multivariable model. In addition, the significant risk factors for Tm relapse were ineffective ART, induction antifungal treatment with itraconazole than intravenous amphotericin B, and shorter duration of itraconazole secondary prophylaxis after completing induction therapy in-hospital (all with significant P-values). Antiretroviral therapy, antifungal treatment and tuberculosis co-infection were main predictors for 6-month Tm fatality as well as relapse. Keywords: Invasive fungal infections, Mortality, Relapse, Talaromyces marneffei, Vietnam.
Association between Prevalence of Talaromycosis and Economic Status in Asia
Authors: Tat Thanh Nguyen
Published: October 2023

Previous studies have shown that geographic niche was a significant risk factor for developing T. marneffei (Tm) infection, and to date there are still lacking data of impact of economic status on the prevalence of Tm. Thus, we conducted this study, aiming to examine the correlation between prevalence of talaromycosis among HIV/AIDS-infected adult population and Asian country income, reported by World Bank data. A comprehensive medical literature review was performed to estimate the prevalence of T. marneffei infection among HIV/AIDS-infected adult population in Tm endemic and non-endemic countries and country income in Asia. Linear regression analyses were used to study the associations between Tm prevalence and Asian country income. Both unadjusted and adjusted models with Tm geographic distribution were analysed. A total of 48 Asian countries were included in the statistical analysis. Geographic distribution of talaromycosis was divided into three main regions: (i) Region 1: Regions of highest incidence of talaromycosis (>100 Tm cases reported in literature); (ii) Region 2: Endemic Tm countries and (iii) Region 3: Countries of imported or travel-associated Tm cases. Estimated Tm prevalence in the three regions were 3.9%, 2% and 0.02%, respectively. There was no statistical difference in GDP among three regions (P = 0.70). The linear regression analyses showed no associations between prevalence estimates of talaromycosis and Asian country income in both unadjusted and adjusted for geographic distribution of T. marneffei (P = 0.83). Most markedly, country geography is still a significant risk factor for T. marneffei infection (P < 0.001). Keywords: Economic status, Invasive fungal infections, Prevalence, Talaromyces marneffei, Vietnam.
Characteristics and Management of Parasuicides at a Tertiary Hospital in Gaborone: A Retrospective Study at the Emergency Department of Princess Marina Hospital
Authors: L Kabongo
Published: October 2023

Parasuicide has become one of the major public health problems worldwide. The WHO is estimated that for every suicide that occurs worldwide, there are up to 20 suicide attempts; however reliable data are not available for most countries. Furthermore, much less is known about attempted suicide across the African continent. Therefore, it was opportune to conduct such project which will provide some valuable statistics on Parasuicide in Botswana. The major objective is to establish the characteristics of Parasuicide at the Princess Marina hospital. Therefore, a retrospective descriptive design (188 patients with Parasuicide) was conducted at the emergency room (January - December 2015). The prevalence of parasuicide is estimated at 0.88%. Overall, females are predominant (79.7%). The age group 21-30 is predominant, mostly students. The factors influencing parasuicide are passional conflict (30.8%), family conflict (20.7%), and social problems (7.9%). Toxic agents (88.2%) were largely used, mostly by females. Among the toxic agents, pharmaceuticals (68.62%) and chemicals (17.55%) were predominant. The overall outcome is largely good (98%). Although patients were widely managed by internal medicine (75.53%), a multidisciplinary approach was established in 10.64% of cases. The study demonstrates that there was no correlation between waiting time, the code of severity and the outcome, as well as the deranged blood and the outcome. In conclusion, Characteristics, and management of Parasuicide were studied. The findings are above described. Further studies may be necessary to elaborate different parameters of parasuicide. Keywords: Characteristics of parasuicide, Management of parasuicide, Parasuicide, Princess Marina Hospital.
The Impact of the Social Classroom Contract on Students with Learning Disabilities
Authors: Daoayan-Biaddang Ladimae Mauline
Published: October 2023

This study explores how social classroom contracts impact students with learning disabilities. The way that students behave and interact has a direct bearing on how they are taught and learned. The research uses a quantitative method to identify the elements influencing the formation of classroom social contracts, explore how they relate to the student code of conduct, and emphasize the beneficial effects of classroom social contracts for students with learning disabilities. The research shows that giving students a choice and a voice in establishing a social contract in the classroom empowers them to take charge of their education and recognize their potential to make a difference. The student code of conduct, a set of rules and expectations for behaviour in the school setting, is also strongly tied to the classroom social contract. Additionally, classroom social contracts give students a stronger feeling of independence and accountability, promoting a socially conscious and active learning environment. This study emphasizes the transformative potential of social classroom contracts for students with learning disabilities with the possibility of increasing their attendance, engagement, and achievement. Keywords: Achievement, Attendance, Code of Conduct, Student Engagement, Voice, and Choice.
Disaster Risk Management and Reduction in Niger: A Review of Tools, Structures, and Mechanisms
Authors: Miko Illya
Published: October 2023

Niger, a vast landlocked country in the arid Sahel region of West Africa, is constantly faced with disasters, with their attendant loss of human life, material goods, economic damage, and damage to critical infrastructure. However, in terms of disaster risk management and reduction, the country has policies and strategies that are consistent with regional and global disaster risk reduction frameworks and instruments. An analysis carried out based on secondary data collection on disaster risk management and reduction tools, structures, and mechanisms revealed the need to make better use of what already exists by improving overall coordination. This can be achieved by putting in place a strong structure that can drive the mobilization of resources and by placing a strong emphasis on the development of operational tools that focus on prevention rather than emergency response. To achieve this, it is important to review data collection methods by simplifying them using geographical information, which could lead to the collection of relevant and timely data to improve the alert mechanism so that it is as rapid as possible and allows the implementation of preventive actions rather than emergency responses. Improving the GRC framework will also require the implementation of coherent land use and urban development strategies with appropriate building standards, supported by adequate funding mechanisms to build resilient infrastructure. Keywords: Disaster risk management, Prevention, Emergency response, Recovery, Niger.
Demokrat Parti Döneminde İzmir’de Cumhuriyet Bayramı Kutlamaları (1950-1960)
Authors: ŞAVKILI Cengiz , KÖSELER Oğuz
Published: October 2023

Türkiye’de Millî Mücadele Dönemi’nin bazı temel gelişmeleri ülkenin millî bayramlarını oluşturmaktadır. Bilhassa 23 Nisan, 19 Mayıs, 30 Ağustos ve 29 Ekim tarihleri bu kapsamdadır. Bu millî bayramlar arasında yer alan Cumhuriyet Bayramı’nın kabulü 19 Nisan 1925’te TBMM tarafından kabul edilen 628 sayılı Kanun ile resmiyet kazanmıştır. Bu tarihten itibaren millî bir bayram olarak kutlanan 29 Ekim Cumhuriyet Bayramı, Tek Parti Dönemi’nde Atatürk’ün de büyük arzusuyla, devlet ricalinin ve halkın yoğun katılımlarıyla gerçekleşmiştir. Bu dönem, Millî Mücadele’de simge bir şehir olan İzmir’de bu coşkulu millî bayram kutlamalarına sahne olmuştur. Bayram kutlamaları, 1950 Genel Seçimi neticesinde iktidara gelen Demokrat Parti’de aynı özen ve ruh ile devam ettirilmeye çalışılmıştır. İzmir’de her yıl valilik tarafından hazırlanan merasim gereği kutlamalar 3 gün sürmüştür. Dolayısıyla söz konusu şehirde bayram olgusu toplumsal dinamiği harekete geçirmiş ve toplumun bireyleri tarafından benimsenmiştir. Bu çalışmada; 1950 Milletvekili Genel Seçiminin ardından iktidara gelen Demokrat Parti Dönemi’nde (1950-1960), İzmir’de “Cumhuriyet Bayramı” kutlamalarının hangi amaçla gerçekleştirildiği, Cumhuriyeti ve onun kazanımlarını temsil eden bu bayramda dönüşüm yaşanıp yaşanmadığı, kutlama programları ve içeriklerinin yanı sıra halkın törenlere gösterdiği ilgi ve alakayı aydınlatan bilgiler verilmeye çalışılmıştır. Bu makalenin yazılmasında; T.C. Cumhurbaşkanlığı Devlet Arşivleri Başkanlığı Cumhuriyet Arşivi belgelerinden, resmî yayınlardan, İzmir’de çıkan yerel gazetelerden ve tetkik eserlerden yararlanılmıştır.
Türkiye Cumhuriyeti Tarihi Araştırmaları Açısından Hilâl-i Ahmer Mecmuası
Authors: UZMAN Nasrullah
Published: October 2023

Türkiye Cumhuriyeti Tarihi araştırmalarında süreli yayınlar önemli bir yere sahiptir. Özellikle dönemine tanıklık eden, kurumsal ve birinci elden kaynak olarak değerlendirilebilecek içeriğe sahip süreli yayınların kaynak değeri daha yüksektir. Türkiye Cumhuriyeti Tarihi araştırmalarında önemli bir kaynak da Hilâl-i Ahmer Cemiyeti’nin resmî yayın organı olan Osmanlı/Türkiye Hilâl-i Ahmer Mecmuası’dır. Osmanlı Hilâl-i Ahmer Cemiyeti, 1868 yılında kurulmuştur. Cemiyetin kuruluş amacı savaş sırasında ordulardaki hasta ve yaralı askerlerin tedavileriyle ilgilenmek ve savaşan tarafların sağlık heyetlerine yardımcı olmaktır. Bir yandan faaliyetlerini sürdüren Osmanlı Hilâl-i Ahmer Cemiyeti, diğer yandan da çalışmaları hakkında halkı bilgilendirmek istemiştir. Bu sayede halkın desteğini de almak istemiştir. Ayrıca halkı aydınlatıcı yazılar yayınlayarak daha fazla kişiye yardımcı olmak istemiştir. Osmanlı Hilâl-i Ahmer Cemiyeti, bu doğrultuda Türkiye Cumhuriyeti Tarihi araştırmalarında önemli bir kaynak olan Osmanlı Hilâl-i Ahmer Mecmuası’nı yayınlamıştır. Hilâl-i Ahmer Mecmuası, verdiği bilgiler açısından Türkiye Cumhuriyeti Tarihine adeta ışık tutmaktadır. İlk sayısı 15 Eylül 1921’de yayınlanan Hilâl-i Ahmer Mecmuası, Hilâl-i Ahmer Cemiyeti’nin faaliyetlerini kamuoyuna duyurmak amacıyla yayın hayatına başlamıştır. Millî Mücadele Dönemi’nde yayın hayatına başlayan Hilâl-i Ahmer Mecmuası, savaş koşullarına rağmen her ay düzenli olarak yayınlanmaya devam etmiştir. Mecmuada Hilâl-i Ahmer’in o ay gerçekleştirdiği faaliyetler, Hilâl-i Ahmer’in ilgi alanına giren konular, halkı bilgilendirici meseleler ve daha birçok konu yayınlanmıştır. Mecmuada yayınlanan birçok içerik, dönemin gazetelerinde de haber olarak yer almıştır. Bu çalışmada Hilâl-i Ahmer Mecmuası’nın tarihçesi, fiziki yapısı, içeriği ve Türkiye Cumhuriyeti Tarihi açısından kaynak değeri incelenecektir.
Cumhuriyet’ten Günümüze Türkiye’de İşsizlik ve Ekonomik Büyümenin Fourier Toda-Yamamoto Nedensellik Yaklaşımı ile İncelenmesi
Authors: ERTÜRKMEN Gülferah
Published: October 2023

Ülkelerin iktisadi anlamdaki güçlerini ve başarılarını ortaya koyan göstergelerin başında işsizlik ve ekonomik büyüme gelmektedir. Bu değişkenler arasındaki ilişki uzun yıllar araştırmalara konu olmuştur. Ekonomik büyüme ve işsizlik, ülkelerin ekonomik anlamdaki başarı ve güçlerini ortaya koyan en önemli göstergelerin başında gelmektedirler. Politika yapıcılar için en temel makroekonomik hedefler arasında, işsizlik oranının azaltılması ve sürdürülebilir ekonomik büyümenin sağlanması öncelikli bir yer tutmaktadır. İşsizlik oranının düşürülmesi, ekonomik büyümeyi artırmanın en etkili politika araçlarından biri olarak kabul edilmektedir. Dolayısıyla, işsizlik ile ekonomik büyüme arasındaki ilişkinin doğru bir şekilde analiz edilmesi, politika yapıcıları için yol gösterici bir öneme sahiptir. Bu iki değişken arasındaki ilişki, uzun yıllardır sorgulanmakla birlikte, literatürde “Okun Yasası” olarak adlandırılan yaklaşım çerçevesinde, ekonomik büyüme ile işsizlik arasında çift yönlü negatif bir ilişkinin geçerli olduğu kabul edilmektedir. Bu çalışma, söz konusu değişkenler arasındaki negatif yönlü ilişkinin Türkiye açısından geçerli olup olmadığını ortaya koymayı amaçlamaktadır. Çalışmada Cumhuriyet’ten günümüze Türkiye’de işsizlik ve ekonomik büyüme arasındaki ilişki 1923-2022 dönemi için analiz edilmiştir. Analiz yöntemi olarak Toda-Yamamoto ve Fourier Toda-Yamamoto nedensellik testlerinden faydalanılmıştır. Nedensellik testlerinden önce Fourier ADF ve Carrion-Silvester birim kök testleri ile değişkenlerin durağanlık mertebeleri araştırılmıştır ve tüm değişkenlerin birinci farkta durağan hâle geldiği gözlemlenmiştir. Sonraki aşamada nedensellik testleri uygulanmış ve Toda-Yamamoto ve Fourier Toda-Yamamoto nedensellik testleri sonucunda işsizlik ve ekonomik büyüme arasında nedensellik ilişkisi elde edilmemiştir.
Cumhuriyetin 100. Yılında Şûra-yı Devlet
Authors: TANRIVERDİ Ayşe Almıla
Published: October 2023

İdarenin yargısal denetiminde şüphesiz ki çok önemli bir yeri bulunan Danıştay’ın geçmişi Osmanlı Devleti’ne kadar dayanmaktadır. Günümüz Danıştay’ı Osmanlı döneminde de Şûra-yı Devlet adında örgütlenmiştir. Ancak o dönemdeki konumu ve görevleri günümüz Danıştay’ından oldukça farklıdır. Osmanlıdaki kuruluş amacından oldukça uzaklaşmış ve neredeyse tek görevi yargılama yapmak olmuştur. Oysa Osmanlı’da yönetime danışma organı olarak görev yapması için kurulmuştur. Devletin tüm işlerinin görüşüleceği makam olması tasarlanmıştır. Her ne kadar idare zamanla yargısal denetime alışmış olsa da yaptığı işlerle ilgili görüş sunulmasını en azından başlangıç aşamasında istemeyecektir. Osmanlı Devleti’nde 1868 yılında kurulan Şûra-yı Devletin yönetime görüş verme görevi şu andakinden çok daha fazlaydı. Ancak zamanla bu görev sembolik olarak kalmıştır. Kanun yapma sürecine ciddi katkılar sağlaması beklenmiştir. Ancak üzerinde yaşanan siyasi çekişmeler görevini tam anlamıyla yapmasını zorlaştırmıştır. Ülkenin yönetiminde söz sahibi olması istenen bir kurumun tartışmaların odağında olması kaçınılmazdır. Zaman zaman kesintilere uğramış, zaman zaman sert eleştirilere göğüs germiş ve nihayetinde köklü bir geçmişe sahip olarak bugünlere gelmiştir. Elbette ki bu süreçte Osmanlı Dönemindeki Tanzimat sonrası reform hareketleri etkili olmakla birlikte Cumhuriyet’in ilanı ve sonraki süreçler de hem Danıştay’da hem de idari yargıda değişmelere ve gelişmelere sebep olmuştur. Kimi uygulamalar Osmanlı’dan taşınmış kimileri de Cumhuriyet’le birlikte kazanılmış ve Şûra-yı Devlet’in nüfuzuna etki etmiştir. Bu çalışmada Cumhuriyet’in yüzüncü yılında Şûra-yı Devlet, cumhuriyet kazanımları temelinde incelenmiştir.
SÍNTESE, CARACTERIZAÇÃO, ATIVIDADE ANTIMICROBIANA DE NANOPARTÍCULAS DE FERRITA DE COBRE E SUA INCORPORAÇÃO EM CIMENTO DE IONÔMERO DE VIDRO
Authors: Ribeiro Thays , Ferreira Luciena , Farias Isabela , Sampaio Fábio , Nunes Jocianelle
Published: October 2023

SYNTHESIS, CHARACTERIZATION, ANTIMICROBIAL ACTIVITY OF COPPER FERRITE NANOPARTICLES AND THEIR INCORPORATION IN GLASS IONOMER CEMENT. Pure cubic copper ferrite (c-CuFe2O4), cerium-doped cubic copper ferrite (c-CuCeFe2O4) and pure tetragonal copper ferrite (t-CuFe2O4) nanoparticles were synthesized from the proteic sol-gel method, and characterized by X-ray diffraction, Rietveld method, FT-IR spectroscopy, and field emission scanning electron microscope. The antibacterial activity of the particles was tested in vitro against pathogenic Gram-positive, Gram-negative bacteria. Thus, it has been observed that the nanoparticles are capable of inhibiting the growth of such microorganisms. The nanoparticles were incorporated into glass ionomer cement, followed by Vickers microhardness evaluation. It is concluded that the cubic copper ferrite showed the best antimicrobial result, being the most suitable for market studies (industrial and biomedical).
AL-QUR’AN SEBAGAI OBJEK KAJIAN STUDI AGAMA ISLAM
Authors: Fauzi M. Ihsan
Published: October 2023

Agama berperan penting sebagai pencetak watak dan moral dalam kehidupan manusia, juga sebagai pencetus sebuah pemikiran masyarakat. Agama hadir sebagai alat penghubung antara manusia dengan penciptanya dan al-Qur’an sebagai dasar landasannya. Artikel ini mengkaji tentang al-Qur’an sebagai objek kajian studi agama Islam dengan beberapa metode pendekatan. Metode yang digunakan dalam penelitian ini adalah studi pustaka. Berdasar penelitian ditemukan bahwa dalam pendekatan normatif, agama merupakan dasar yang murni berasal dari Tuhan yang belum tercampur dengan  nalar pikiran manusia. Di dalamnya mengkaji tekstual al-Qur’an yang menjelaskan arti norma dan pokok penting yang terkandung di dalamnya. Adapun pendekatan sosiologi itu lebih condong kepada kajian tentang kehidupan masyarakat, baik itu hubungan antar individu maupun hubungan secara berkelompok. Dalam pendekatan ini yang menjadi fokus utama adalah hubungan sosial masyarakat. Adapun untuk pendekatan antropologi itu merupakan kajian yang membahas tentang sejarah perkembangan manusia. Dimana budaya, ras dan bahasa menjadi titik berat kajian dalam pendekatan tersebut. Pendekatan sosiologi dan antropologi memiliki relasi pada kajian living Qur’an. Keduanya memiliki hubungan dalam konteks budaya dan sosial dalam melihat bagaimana masyarakat menyikapi dan merespon al-Qur’an dikehidupan mereka sehari-hari.
REVIEW OF PURCHASING AND SELLING NFTS IN ISTIHSAN
Authors: Fad Mohammad Farid
Published: October 2023

AbstractSo far, NFTs have been defined as digital tokens that are shaped like ownership certificates for virtual and physical assets. These NFTs are usually traded online and are often paid for using cryptocurrencies, especially Ethereum. However, the problem is that in 2021 the MUI issued a fatwa that cryptocurrency is illegal. This is because it there are elements of qimar, dharar, and gharar. For this reason, it is necessary to study the methodology of Islamic law regarding Non-Fungible Tokens (NFT) through istihsan (juristic preference). This study uses a qualitative approach. The data were collected from library study, documentation and observation. In analyzing  the data used descriptive-analytic analysis with the approach used is ushuliyah. This study revealed that from istihsan point of view, transactions using Non-Fungible Tokens are permitted. This is because, from Qiyas Khafi perspective, NFT is known as the underlying assets of the transaction. Up to the operational level, if qiyas khafi is of greater benefit, then qiyas jali may be abandoned. What is used is qiyas khafi to maintain the principles of maqasid shari'a. Therefore, within the istihsan framework, Non-Fungible Token transactions are allowed through qiyas khafi due to an element of greater benefit.Keywords: Non-Fungible Token Transaction; Istihsan; Maqasid Shari’a, AbstrakSelama ini NFT didefinisikan sebagai token digital yang berbentuk seperti sertifikat kepemilikan untuk aset virtual dan fisik. NFT ini adalah biasanya diperdagangkan secara online dan sering dibayar untuk menggunakan cryptocurrency, khususnya Ethereum. Namun yang menjadi persoalan ialah pada tahun 2021 MUI pernah memfatwakan haram penggunaan cryptocurrency karena mengandung unsur gharar, dharar, dan qimar. Untuk itu, diperlukan kajian metodologi hukum Islam tentang Non-Fungible Token (NFT) melalui istihsan. Penelitian ini menggunakan pendekatan kualitatif. Sementara metode pengumpulan data yang dipakai dalam penelitian ini adalah metode literatur, dokumentasi dan observasi. Dalam menganalisis data yang telah dikumpulkan, peneliti menggunakan analisis deskriptif-analitis dengan pendekatan ushuliyah. Hasil penelitian ini menyatakan bahwa dalam tinjauan istihsan, transaksi dengan menggunakan Non-Fungible Token diperbolehkan. Hal ini dikarenakan dalam tinjauan qiyas khafi, NFT dikenal asset yang mendasari transaksi tersebut (underlying assets). Hingga dalam tataran operasionalnya, bila qiyas khafy lebih besar manfaatnya, maka qiyas jaly itu boleh ditinggalkan dan yang dipakai adalah qiyas khafy demi terpeliharanya prinsip-prinsip maqasid syari’ah. Oleh karena itu, dalam kerangka istihsan, transaksi Non-Fungible Token diperbolehkan melalui qiyas khafi dikarenakan adanya unsur maslahat yang lebih besar.Keywords: Non-Fungible Token; Istihsan; Maqashid Syari’ah.
AKURASI ARAH KIBLAT MASJID KUNO AL-ABROR BANDAR LAMPUNG DENGAN METODE RASHDUL KIBLAT HARIAN
Authors: Khairunnisa Ariba , Aryani Dian Ika
Published: October 2023

Masjid Al-Abror adalah salah satu masjid kuno yang didirikan pada tahun 1914. Arah kiblat masjid ini dijadikan rujukan bagi masyarakat sekitar yang akan membangun masjid baru sehingga arah kibatnya harus akurat. Namun hal ini menjadi masalah ketika masjid Al-Abror sendiri arah kiblatnya melenceng. Untuk itu diperlukan penelitian lebih lanjut mengenai keakurasian arah kiblat pada masjid ini dan juga pandangan para jamaah masjid terhadap adanya rekonstruksi tersebut. Penelitian ini menggunakan metode penelitian lapangan untuk mengecek akurasi arah kiblat masjid dan metode wawancara kepada jamaah masjid untuk megetahui respon mereka terhadap rekonstruksi akurasi arah kiblat. Penulis melakukan pengecekan arah kiblat Masjid Al-Abror menggunakan  metode rashdul kiblat harian dan metode theodolite dengan perhitungan azimuth kiblat dengan data ephemeris yang diterbitkan oleh  Departemen Agama RI. Hasil dari perhitungan azimuth kiblat ini kemudian dikalibrasikan dengan rashdul kiblat harian. Dari hasil perhitungan dan analisa membuktikan bahwa Masjid Al-Abror mengalami kemelencengan sebesar 10o 50’ 38,63” kurang ke utara. Kedua metode menunjukkan bahwa masjid Al-Abror berada di azimuth 284o 27’ 2.75” UTSB yang seharusnya bernilai 295o 17’ 41.38”. Hasil wawancara dengan pengurus dan jamaah masjid adalah bahwa mereka menerima hasil penelitian dan mempertimbangkan untuk mengubah arah kiblatnya dengan hasil pengukuran setelah dilakukan musyawarah.
Constituição de um córpus para o português de Roraima (séc. XVIII)
Authors: dos Santos Procópio Eliabe
Published: October 2023

Este texto objetiva apresentar a constituição de um córpus histórico para o estudo do português em Roraima. Para tanto discute o conceito de implantação linguística (GRAMLEY, 2012; BARZ, SIEGEL, 1988) para contextualizar o estabelecimento sociolinguístico da língua portuguesa na porção norte da Amazônia; e o de silêncio documental (FARAGE, 1986) para explicar a escassez documental sobre a colonização portuguesa do Rio Branco. Em seguida, apresenta os critérios de seleção textual do córpus, composto pela juntada do processo diplomático da Questão do Pirara, disputa territorial entre Brasil (antes Portugal) e Reino Unido. Os principais critérios são o cronológico (final do século XVIII, quando se constrói o Forte São Joaquim, marco da ocupação portuguesa), o textual (documentos da administração portuguesa, em especial os relatos) e o temático (documentos que façam menção extensiva aos espaços roraimenses de outrora, afinal alguns textos apenas mencionam algo como ‘Rio Branco’ sem alongar suas descrições). Ainda sobre a composição do córpus, esta pesquisa relata o levantamento documental realizado no Museu Amazônico, onde está conservado o patrimônio documental do projeto Resgate/COLUSO, e aponta outros arquivos. Por último, a conclusão deste texto enfatiza a defensa de criação (ou fortalecimento) de uma filologia amazônica, cujos propósitos são coletar material textual (levantamento e tratamento de fontes primárias) e descrever a implantação do português na Amazônia brasileira, que se caracteriza pela gestão pombalina e o contato mais efetivo entre a língua portuguesa e as línguas europeias e ameríndias.
Fake news e cidadania digital: procedimentos de checagem de fatos em textos multissemióticos
Authors: Oliveira do Nascimento Isadora , de Lima-Neto Vicente
Published: October 2023

Não é de hoje que a desinformação assola o mundo. Há uma série de relatos de fake news desde a Antiguidade Clássica (MARQUÉS, 2019), passando por todos os momentos da história da humanidade e chegando ao ápice nos últimos anos, sobretudo com o desenvolvimento de tecnologias digitais e sites de redes sociais. Pode-se dizer que as fake news mudaram o curso da história da humanidade, e não foi diferente no Brasil: os golpes militares de 1889, 1937 e 1964, por exemplo, foram frutos da desinformação. Neste trabalho, nosso objetivo é o de sugerir critérios objetivos que permitam a didatização da checagem de textos multissemióticos fundados na desinformação, ou o que mais popularmente conhecemos como fake news (FN), considerando a acepção da cidadania digital envolta no compartilhamento consciente e crítico de informações. Para isso, amparamo-nos nos estudos de Wardle e Derakshan (2017), que versam sobre o Quadro da Desordem da Desinformação; em Seserig e Máximo (2017) e Tobias (2018), que apontam elementos caracterizadores da desinformação; em Kress (2010), Paiva (2021) e Ribeiro (2021), para a discussão sobre textos multissemióticos, e em Nascimento (2020) e Nascimento; Lima-Neto (2021), sobre procedimentos de checagem de fatos. Metodologicamente selecionamos duas FN, uma com temática política e outra sanitária, que circularam em meio digital e já foram desmistificadas por agências de checagem. Os resultados apontam que há dois grupos de critérios mais amplos que auxiliam na identificação: os de expressão, mais imediatos; e os de conteúdo, menos imediatos, com exigência de confirmação de evidências. Ambos os grupos parecem dar conta de identificar FN em diferentes estruturas e temáticas.
Sob um olhar dialógico-multimodal: a matriz gesto e fala como palco de entrada da criança na linguagem
Authors: Xavier de Holanda Driely , Carvalho Bezerra Cavalcante Marianne , Oliveira da Silva Eriglauber Edivirgens , Da silva Danieli Maria , Pereira de Lima Valdenice
Published: October 2023

O objetivo deste trabalho é analisar o processo de aquisição da linguagem em uma perspectiva multimodal, em situações dialógicas com mãe-bebê, por acreditarmos que esse é o cenário pelo qual a matriz gesto e fala se efetiva e se torna palco de entrada. Acreditamos que a interação da mãe com a criança exerce influência nessa construção, e, através dela, é possível compreender o funcionamento multimodal da linguagem e a entrada da criança na língua sustentada na matriz gesto e fala explorada pela mãe durante a interação. Dessa forma, recorreremos à abordagem dialógico-discursiva do Ciclo de Bakhtin (2006), por acreditarmos que é nesse contexto dialógico que a criança é inserida na língua, pois é justamente a partir dos movimentos discursivos que a fala da criança pode ser analisada do ponto de vista do dialogismo, como afirmam Del Ré, Hilário e Vieira (2021). Para compreendermos a interação mãe/bebê e como a matriz gesto e fala se constitui nessa interação, embasamo-nos nos autores Scarpa (1999), Mc Neill (1985) e Barros (2012). Metodologicamente, nossos dados foram coletados em sessões de filmagens realizadas na casa da díade (mãe/bebê), com duração aproximada de 15 a 20 minutos, a cada quinze dias. Os bebês têm, em média, de 0 a 36 meses, e são gravados em situação natural. Posteriormente, transcrevemos por meio do ELAN. Os resultados mostram que a matriz gesto e fala efetivada pela mãe durante a interação mãe-bebê insere a criança no mundo dos gêneros textuais sob uma perspectiva multimodal e dialógica de linguagem.
Linguagem inclusiva e comunicação não sexista na Universidade Federal de Sergipe
Authors: de Barros Santos Verônica , Meister Ko. Freitag Raque , Do Nascimento Raquel , Santos Silva Elizabeth , Sousa de  Gois Túlio
Published: October 2023

As mudanças na linguagem com o objetivo de tornar a comunicação menos sexista são parte de uma pauta social pela igualdade de gênero. A discussão vem ganhando destaque nas redes sociais, na comunicação informal e formal, inclusive em textos oficiais elaborados por instituições governamentais. Este estudo tem como objetivo identificar as ocorrências de expressões de linguagem inclusiva de gênero em documentos elaborados pela Universidade Federal de Sergipe no âmbito dos Conselhos Superiores, entre os anos 2017 e 2022. Foi realizada a análise da expressão variável do gênero dos referentes nominais relativos a pessoas em corpus constituído por projetos pedagógicos de cursos de graduação e por resoluções da UFS. A análise usou linguagem de programação Python com bibliotecas para busca de padrões em texto e geração de um conjunto de dados das ocorrências de referência a entidades. Os resultados mostram que existem poucas ocorrências de expressões que denotam uma linguagem inclusiva de gênero e que estas aumentaram nos últimos anos, período em que mulheres assumiram postos na alta administração da UFS. Estes resultados corroboram que as mudanças sociais – a  presença de mulheres em espaços dominados pelos homens – atuam na igualdade de gênero, por exemplo, na tentativa de estabelecer uma comunicação mais inclusiva.
Nursing Students’ Perceived Confidence in eHealth Concepts and Willingness to
Learn: A Multi-site Cross-sectional Survey in India
Authors: Baby Priya , Ravi Ramya Kundayi
Published: October 2023

Background::

With the digitalization of health care, nurses are required to possess adequate eHealth competence.

Aim::

This study aimed to explore the perceived confidence in eHealth concepts and willingness for training among nursing students.

Materials and Methods::

A cross-sectional survey was conducted among 572 undergraduate nursing students recruited by convenient sampling technique from two selected
nursing colleges in Southern and Northern India. A structured questionnaire was used to collect data. The data was analysed using SPSS. A p-value
of less than 0.05 was taken as statistically significant.

Results::

A total of 572 students completed the survey. The age of the participants ranged from 18 to 28 years, with a mean of 20.7 (SD 2.0) years. Most of
the students (92.5%) used smartphones as their source of internet. More than half (66.1%) of the students were confident in various eHealth
concepts. Those who were not confident in a particular eHealth concept were more willing to learn the same concept than those who were
confident.

Conclusion::

The study recommends preparing future nurses having knowledge of various eHealth concepts using curricular and co-curricular activities to
increase their confidence and enable them to work effectively in the era of digital transformation of health care.
Transperitoneal Laparoscopic Adrenalectomy for Metachronous Contralateral
Adrenal Metastasis from Oligometastatic Renal Cell Cancer: Case Report and
Review of the Literature
Authors: Öğreden Ercan , Oguz Ural , Demirelli Erhan , Sabri Tok Doğan , Akyol Safa , Öksüz Hülya , Aslan Serdar
Published: October 2023

Background::

The definition of oligometastasis is still controversial. Cytoreductive nephrectomy and metastasectomy are important approaches in selected
patients with oligometastasis for improving survival. We aimed to present our laparoscopic metastasectomy experience in a rare case of
contralateral adrenal metastasis in an oligometastatic kidney tumor.

Case Report::

A 52-year-old male patient was admitted to our clinic with the diagnosis of an incidental right renal mass. On contrast-enhanced abdominal CT
revealed a mass reaching approximately 8 cm in diameter in the right kidney located in the middle pole. On contrast-enhanced thorax, CT showed
a metastatic lesion in the left main bronchus bifurcation. The patient underwent an open radical nephrectomy with the diagnosis of an
oligometastatic right renal mass. His pathology was reported as clear cell renal cell carcinoma (ccRCC). The patient was referred to the medical
oncology clinic for immunotherapy. The metastatic lesion in the lung completely regressed in the follow-up of the patient who was started on Chek
point inhibitors. However, he was referred to our clinic after an incidental metachronous mass was detected in the contralateral left adrenal in FDG
PET/CT (SUVmax: 6.7) in 1st year. Dynamic contrast-enhanced MRI was performed to reevaluate and for mass characterization, and a 4 cm mass
was observed in the left contralateral adrenal. Laparoscopic metastasectomy was performed for the left adrenal mass. No recurrence or adrenal
insufficiency developed in the 6-month follow-up after discharge.

Conclusion::

Transperitoneal adrenalectomy is a minimally invasive method that can be safely performed in metastatic adrenal masses. Although contralateral
adrenal metastasis is rare in ccRCC, it should be kept in mind that adrenal metastasis may develop in the late period in patients with a history of
renal cancer.
Dental Tissue Engineering by Neural Differentiation of Dental Stem Cells and Nano-systems: A Review
Authors: Abdolahinia Elaheh Dalir , Khatibi Seyed Mahdi Hosseiniyan , Sharifi Simin , Dizaj Solmaz Maleki
Published: October 2023

Background:

Pulpitis is a pulpal inflammation. It generally occurs when there is inflammation within a tooth as a result of anything like grinding or decay. After dental inflammation, microcirculation and sensory nerve activity seem to play the most critical role in reducing inflammation. Therefore, researchers emphasize the study of dental nerve activity, especially in acute clinical problems in inflamed teeth and pulp regeneration. This review aims to investigate the possibility of using dental stem cells to regenerate dental nerves in order to repair dentin-pulp complexes for maintaining and restoring tooth structure and function, which nanosystems can help in this matter.

Materials and Methods:

In this paper, we review the literature regarding the theory of dental tissue engineering by neural differentiation of dental stem cells and nano-systems, and the comprehensive search on PubMed, Scopus, and Web of Science was conducted up to July 2022.

Results:

According to recent studies, dental soft and hard tissue healing also includes nerve fibers. A deeper understanding of how dental nerves are implicated in pulpitis may assist endodontic treatment. Stem cell-based treatments may be used to regenerate dental nerves to repair dentin-pulp complexes to maintain and restore tooth structure and function.

Conclusion:

The emphasis on dental nerve regeneration appears to be a critical stage in fostering spontaneous tooth regeneration as well as a sustainable tooth regeneration method. It is essential to further investigate dental tissue engineering by neural differentiation of dental stem cells.