bluuebunny/crossref_metadata_2025 huggingface dataset:
Die laienverständliche Version der 2018 EULAR Empfehlungen zu körperlicher Aktivität von Menschen mit entzündlich-rheumatischen und degenerativen Erkrankungen
Authors: Niedermann K. , Rausch A. K. , Braun J. , Becker H. , Böhm P. , Bräm R. , Gilliam-Feld G. , Kiefer D. , Kurz R. , Schönfelder M. , Stamm T. , Kiltz U.
Published: October 2021

Hintergrund

Körperliche Aktivität und spezifisches Training haben großen gesundheitlichen Nutzen. Empfehlungen zum Management von rheumatoider Arthritis (RA), Spondyloarthritis (SpA) sowie Hüft- und Kniegelenkarthose (HKA) sind bisher in Bezug auf Art und Dosierung aber unspezifisch. Darum wurden die 2018 EULAR Empfehlungen zu körperlicher Aktivität für Menschen mit entzündlich-rheumatischen und degenerativen Erkrankungen formuliert. Sie bestehen aus 4 übergeordneten Prinzipien und 10 Empfehlungen. Die EULAR Bewegungsempfehlungen wurden auch als laienverständliche Version in englischer Sprache publiziert.

Ziel

Übersetzung der laienverständlichen Version ins Deutsche und sprachliche Validierung in Deutschland, Österreich und der Schweiz.

Methoden

Eine professionelle Übersetzung ins Deutsche wurde von den Autor*innen einschließlich Personen mit RA, SpA und HKA zu einer präfinalen Version bearbeitet. Anschließend wurden in den 3 Ländern je 8 Interviews mit Personen mit RA, SpA und HKA durchgeführt, um die Verständlichkeit, Wortwahl, Vollständigkeit und Umsetzbarkeit zu prüfen. Die Patientenvertreter*innen der Autor*innengruppe bewerteten anonym ihre Zustimmung zur finalen Version auf einer Skala von 0 bis 10.

Ergebnisse

Die professionelle Übersetzung wurde von den Autor*innen und auf Grundlage der Interviews substanziell überarbeitet. Dabei wurden Formulierungen angepasst, um Lesbarkeit und Verständlichkeit zu verbessern und Aussagen zu präzisieren. Inhalt und Struktur des Originaltextes wurden dabei nicht verändert. Die Zustimmung zu den einzelnen Empfehlungen lag zwischen 10 (SD 0) und 7,6 (SD 1,67).

Diskussion

Für Menschen mit RA/SpA/HKA sollten die EULAR Bewegungsempfehlungen in deren Muttersprache vorliegen. Die laienverständliche deutsche Version ist valide und wurde in allen 3 Ländern gut akzeptiert. Damit können die EULAR Bewegungsempfehlungen verständlich und praktikabel vermittelt werden.
Peri-implant fracture: a rare complication after intramedullary fixation of trochanteric femoral fracture
Authors: Halonen Lauri M. , Stenroos Antti , Vasara Henri , Kosola Jussi
Published: October 2021

Introduction

Trochanteric femoral fractures are among the most common operatively treated fractures. Intramedullary fixation has become the treatment of choice in many centers around the world. Nevertheless, the knowledge of rare complications of these fractures is limited. In this study, the incidence and treatment strategies for peri-implant fractures (PIF) were assessed.

Materials and methods

A single-center retrospective cohort study was done on 987 consecutive operatively treated trochanteric fractures. PFNA cephalomedullary nail was used as a fixation method. All patients were followed up from patient records for peri-implant fractures. Plain radiographs as well as different salvage methods were analyzed and compared.

Results

The total rate of peri-implant fractures was 1.4% (n = 14). The rate of PIF for patients treated with short (200 mm) nails, intermediate-length (240 mm) nails, and long nails was 2.7% (n = 2), 1.5% (n = 11), and 0.7% (n = 1), respectively (ns, p > 0.05 for difference). Treatment of choice for PIF was either ORIF with locking plate (57%, n = 8) or exchange nailing (43%, n = 6). None of the PIF patients needed additional surgeries for non-union, malunion, or delayed union.

Conclusions

A PIF is a rare complication of intramedullary fixation of trochanteric fractures. It can be treated with either locking plates or exchange nailing with sufficient results. There are no grounds for favoring long nails to avoid PIFs.
Notes on the creation and manipulation of solid solution models
Authors: Myhill Robert , Connolly James A. D.
Published: October 2021

A large class of solid solution models are formulated on the premise that exchange of chemical species takes place on a finite number of unique crystallographic sites, and that the thermodynamic properties of the solution are a function of the proportions of species occupying each of the sites. These models are broadly classified as being of Bragg–Williams-type. They form an excellent first order approximation of non-ideal mixing and long-range order. In this article we present the mathematical framework common to all Bragg–Williams models, introducing necessary concepts from geometry, set theory and linear algebra. We combine this with a set of mathematical tools which we have found useful in building and using such models. We include several worked examples to illustrate key concepts and provide general expressions which can be used for all models. This paper is split into two parts. In the first part, we show how the valences of the species occupying each site and the total charge of the species involved in site exchange are sufficient to define the space of valid site occupancies of a solid solution, and to compute the endmembers bounding that space. We show that this space can be visualised as a polytope, i.e, an n-dimensional polyhedron, and we describe the relationship between site-occupancy space and compositional space. In the second part of the paper, we present the linear algebra required to transform descriptions of modified van Laar and subregular solution models from one independent endmember basis to another. The same algebra can also be used to derive macroscopic endmember interactions from microscopic site interactions. This algebra is useful both in the initial design of solution models, and when performing thermodynamic calculations in restricted chemical subsystems. A polytope description of solid solutions is used in the thermodynamic software packages Perple_X and burnman. The algorithms described in this paper are made available as python code.
Impact of pulse oximetry screening to detect congenital heart defects: 5 years’ experience in a UK regional neonatal unit
Authors: Singh Yogen , Chen Si Emma
Published: October 2021

Pulse oximetry screening (POS) has been shown to be an effective, non-invasive investigation that can detect up to 50–70% of previously undiagnosed congenital heart defects (CHDs). The aims of this study were to assess the accuracy of POS in detection of CHDs and its impact on clinical practice. All eligible newborn infants born between 1 Jan 2015 and 31 Dec 2019 in a busy regional neonatal unit were included in this prospective observational study. A positive POS was classified as two separate measurements of oxygen saturation < 95%, or a difference of > 2% between pre- and post-ductal circulations. Overall, 23,614 infants had documented POS results. One hundred eighty nine (0.8%) infants had a true positive result: 6 had critical CHDs, 9 serious or significant CHDs, and a further 156/189 (83%) infants had significant non-cardiac conditions. Forty-three infants who had a normal POS were later diagnosed with the following categories of CHDs post-hospital discharge: 1 critical, 15 serious, 20 significant and 7 non-significant CHDs. POS sensitivity for detection of critical CHD was 85.7%, whereas sensitivity was only 33% for detection of major CHDs (critical and serious) needing surgery during infancy; specificity was 99.3%.

Conclusion: Pulse oximetry screening showed moderate to high sensitivity in detection of undiagnosed critical CHDs; however, it failed to detect two-third of major CHDs. Our study further emphasises the significance of adopting routine POS to detect critical CHDs in the clinical practice. However, it also highlights the need to develop new, innovative methods, such as perfusion index, to detect other major CHDs missed by current screening tools.

What is Known:• Pulse oximetry screening is cost effective, acceptable, easy to perform and has moderate sensitivity and high specificity in detection of critical congenital heart defects.• Pulse oximetry screening has been implemented many countries including USA for detection of critical congenital heart defects, but it is not currently recommended by the UK National Screening Committee.

What is New:• To our knowledge, this is the first study describing postnatal detection and presentation of all the infants with congenital heart defects over a period of 5 years, including those not detected on the pulse oximetry screening, on the clinical practice. • It emphasises that further research required to detect critical congenital heart defects and other major CHDs which can be missed on the screening tools currently employed in clinical practice.
Nonparametric extrapolation of extreme quantiles: a comparison study
Authors: Banfi Fabiola , Cazzaniga Greta , De Michele Carlo
Published: October 2021

The extrapolation of quantiles beyond or below the largest or smallest observation plays an important role in hydrological practice, design of hydraulic structures, water resources management, or risk assessment. Traditionally, extreme quantiles are obtained using parametric methods that require to make an a priori assumption about the distribution that generated the data. This approach has several limitations mainly when applied to the tails of the distribution. Semiparametric or nonparametric methods, on the other hand, allow more flexibility and they may overcome the problems of the parametric approach. Therefore, we present here a comparison between three selected semi/nonparametric methods, namely the methods of Hutson (Stat and Comput, 12(4):331–338, 2002) and Scholz (Nonparametric tail extrapolation. Tech. Rep. ISSTECH-95-014, Boeing Information and Support Services, Seattle, WA, United States of America, 1995) and kernel density estimation. While the first and third methods have already applications in hydrology, Scholz (Nonparametric tail extrapolation. Tech. Rep. ISSTECH-95-014, Boeing Information and Support Services, Seattle, WA, United States of America, 1995) is proposed in this context for the first time. After describing the methods and their applications in hydrology, we compare their performance for different sample lengths and return periods. We use synthetic samples extracted from four distributions whose maxima belong to the Gumbel, Weibull, and Fréchet domain of attraction. Then, the same methods are applied to a real precipitation dataset and compared with a parametric approach. Eventually, a detailed discussion of the results is presented to guide researchers in the choice of the most suitable method. None of the three methods, in fact, outperforms the others; performances, instead, vary greatly with distribution type, return period, and sample size.
Deprescribing in palliative patients with cancer: a concise review of tools and guidelines
Authors: van Merendonk Lisanne N. , Crul Mirjam
Published: October 2021

Purpose

Palliative cancer patients can benefit from deprescribing of potentially inappropriate medications (PIMs). Tools and guidelines developed for the geriatric population are mainly available. This systematic review gives an overview of available guidelines and tools to deprescribe for palliative cancer patients.

Methods

A systematic search was carried out using the databases SCOPUS and PubMed. Studies focused on palliative cancer patients were included.

Results

The search identified 137 studies of which 15 studies were included in this systematic review. Six of the included tools were developed specifically for cancer patients. One of these tools was externally validated and applied in several studies and settings. Guidelines or tools that were not specifically developed for cancer patients but that were applied on cohorts of palliative cancer patients were also included.

Conclusion

Tools developed for geriatric patients contain drugs that are not inappropriate when used in the palliative cancer care setting. Tools developed for cancer patients are more suitable and can be applied in combination with stepwise methods to individualize deprescribing per patient. The tools and guidelines described in this systematic review can be used to further implement deprescribing in the clinical routine for palliative cancer patients.
A review of trauma and orthopaedic randomised clinical trials published in high-impact general medical journals
Authors: Farrow Luke , Gardner William T. , Ablett Andrew D. , Kutuzov Vladislav , Johnstone Alan
Published: October 2021

Introduction

The recent past has seen a significant increase in the number of trauma and orthopaedic randomised clinical trials published in “the big five” general medical journals. The quality of this research has, however, not yet been established.

Methods

We therefore set out to critically appraise the quality of available literature over a 10-year period (April 2010–April 2020) through a systematic search of these 5 high-impact general medical journals (JAMA, NEJM, BMJ, Lancet and Annals). A standardised data extraction proforma was utilised to gather information regarding: trial design, sample size calculation, results, study quality and pragmatism. Quality assessment was performed using the Cochrane Risk of Bias 2 tool and the modified Delphi list. Study pragmatism was assessed using the PRECIS-2 tool.

Results

A total of 25 studies were eligible for inclusion. Over half of the included trials did not meet their sample size calculation for the primary outcome, with a similar proportion of these studies at risk of type II error for their non-significant results. There was a high degree of pragmatism according to PRECIS-2. Non-significant studies had greater pragmatism that those with statistically significant results (p < 0.001). Only 56% studies provided adequate justification for the minimum clinically important difference (MCID) in the population assessed. Overall, very few studies were deemed high quality/low risk of bias.

Conclusions

These findings highlight that there are some important methodological concerns present within the current evidence base of RCTs published in high-impact medical journals. Potential strategies that may improve future trial design are highlighted.

Level of evidence

Level 1.
Microscale size effects in piezomagnetic material for the anti-plane problem
Authors: Xu Mingxiu , Askes Harm , Shang Xinchun , Gitman Inna M.
Published: October 2021

A continuum model of piezomagnetic material with strain, magnetic and piezomagnetic coupling gradient effects is proposed using a variational principle in this work. This model is employed to an anti-plane problem, and a general solution is constructed in polar coordinates. Special attention is paid to microstructural effects on the magnetic and mechanical response in an infinite piezomagnetic medium with a void. It is found that the microstructural length scales have a significant influence on the mechanic and magnetic fields. The three length scales (corresponding to strain, magnetic and piezomagnetic coupling gradients) are indispensable to describe the nonlocal effects of piezomagnetism. Additionally, controlling the direction and magnitude of the magnetic field at the edge of the void can be achieved by adjusting the microstructural length scales of the piezomagnetic medium.
Drivers of immersive virtual reality adoption intention: a multi-group analysis in chemical industry settings
Authors: Toyoda Ryo , Russo Abegão Fernando , Gill Sue , Glassey Jarka
Published: October 2021

The present study uses the modified Unified Theory of Acceptance and Use of Technology 2 to examine the effect of factors such as performance expectancy (PE), effort expectancy (EE), social influence (SI), and hedonic motivation (HM) that may motivate operators and employees to adopt IVR-based technology into their training. Results of a multi-group analysis based on nationality, prior IVR experience, and/or length of work experience, to analyse the potential similarities and/or differences in perception and acceptance towards using IVR-based technology are also presented. The quantitative research data were gathered using an online questionnaire from 438 chemical operators and/or employees who either speak German, French, or English. Partial least squares structural equation modelling and multi-group analysis based on SmartPLS™ version 3 were used to carry out the path and multi-group analyses. The results show that the behavioural intention (BI) towards adoption of IVR was influenced by PE, EE, and HM for all abovementioned subpopulation. However, the relationship of SI to BI was not supported for respondents with prior IVR experience and for respondents coming from Western region. Although Henseler’s-based multi-group PLS analysis reveals that there was no significant difference between the group comparisons, it is still important to take into account these socio-demographic factors as there are definite group differences in terms of the ranking order of each construct for the IVR adoption intentions among each subpopulation. The implications and future directions were discussed.
Now you see it, now you don’t: dynamism amplifies the typicality effect
Authors: Clewley Richard , Nixon Jim
Published: October 2021

Some safety events do not stabilise in a coherent state, presenting with transient or intermittent features. Such dynamism may pose problems for human performance, especially if combined with non-typical stimuli that are rarely encountered in everyday work. This may explain undesirable pilot behaviour and could be an important cognitive factor in recent aircraft accidents. Sixty-five airline pilots tested a real-world typicality gradient, composed of two cockpit events, a typical event, and a non-typical event, across two different forms of dynamism, a stable, single system transition, and an unstable, intermittent system transition. We found that non-typical event stimuli elicited a greater number of response errors and incurred an increased response latency when compared to typical event stimuli, replicating the typicality effect. These performance deteriorations were amplified when a form of unstable system dynamism was introduced. Typical stimuli were unaffected by dynamism. This indicates that dynamic, non-typical events are problematic for pilots and may lead to poor event recognition and response. Typical is advantageous, even if dynamic. Manufacturers and airlines should evolve pilot training and crew procedures to take account of variety in event dynamics.
Preoperative brain shift is a prognostic factor for survival in certain neurosurgical diseases other than severe head injury: a case series and literature review
Authors: Missori Paolo , La Torre Giuseppe , Lazzari Susanna , Paolini Sergio , Peschillo Simone , Martini Stefano , Palmarini Valeria
Published: October 2021

Preoperative brain shift after severe brain injury is a prognostic factor for survival. The aim of this study was to determine whether preoperative brain shift in conditions other than severe head injury has significant prognostic value. We analyzed a radiological database of 800 consecutive patients, who underwent neurosurgical treatment. Brain shift was measured at two anatomical landmarks: Monro’s foramina (MF) and the corpus callosum (CC). Four hundred seventy-three patients were included. The disease exerting the highest mean brain shift was acute subdural hematoma (MF 11.6 mm, CC 12.4 mm), followed by intraparenchymal hematoma (MF 10.2 mm, CC 10.3 mm) and malignant ischemia (MF 10.4 mm, CC 10.5 mm). On univariate analysis, brain shift was a significant negative factor for survival in all diseases (p < 0.001). Analyzed individually by group, brain shift at both anatomical landmarks had a statistically significant effect on survival in malignant ischemia and at one anatomical landmark in chronic subdural and intraparenchymal hematomas. Multivariate analysis demonstrated that the only independent factor negatively impacting survival was brain shift at MF (OR = 0.89; 95% CI: 0.84–0.95) and CC (OR = 0.90; 95% CI: 0.85–0.96). Brain shift is a prognostic factor for survival in patients with expansive intracranial lesions in certain neurosurgical diseases. MF and CC are reliable anatomical landmarks and should be quoted routinely in radiological reports as well as in neurosurgical practice.
Barriers and wellbeing-oriented enablers of intergenerational innovation in the digital age
Authors: Nurhas Irawan , Geisler Stefan , Ojala Arto , Pawlowski Jan M.
Published: October 2021

So far, researchers have used a wellbeing-centered approach to catalyze successful intergenerational collaboration (IGC) in innovative activities. However, due to the subject’s multidisciplinary nature, there is still a dearth of comprehensive research devoted to constructing the IGC system. Thus, the purpose of this study is to fill a research void by providing a conceptual framework for information technology (IT) system designers to use as a jumping-off point for designing an IGC system with a wellbeing-oriented design. A systematic literature study was conducted to identify relevant terms and develop a conceptual framework based on a review of 75 selected scientific papers. The result consists of prominent thematic linkages and a conceptual framework related to design technology for IGC systems. The conceptual framework provides a comprehensive overview of IGC systems in the innovation process by identifying five barrier dimensions and using six wellbeing determinants as IGC catalysts. Moreover, this study discusses future directions for research on IGC systems. This study offers a novel contribution by shifting the technology design process from an age-based design approach to wellbeing-driven IGC systems. Additional avenues for investigation were revealed through the analysis of the study’s findings.
Poland’s stance on CAI: no need for haste
Authors: Szczudlik Justyna
Published: October 2021

Poland was among vocal critics of the acceleration and finalization of CAI talks by the end of 2020. Among the reasons
were doubts about the timing and political circumstances in the EU such as the role of Germany as a driving force for CAI due to its economic dependence on China, and Commission mandate for talks that was granted several years ago in a very different situation both in China and Europe. Poland was also critical about bypassing the USA, in a sense of bringing CAI talks up to speed during the transition period, before Biden sworn. However, after finalization of the agreement, Polish government (as well as the biggest opposition party) presents a rather positive assessment of CAI and opts for ratification. Notwithstanding, all Polish MEPs have endorsed the European Parliament resolution to freeze ratification process.
Akut symptomatische Anfälle und die Abgrenzung zum Status epilepticus auf der Intensivstation bei Kindern und Erwachsenen
Authors: Leitinger Markus
Published: October 2021

Akut symptomatische Anfälle (ASA) finden sich häufig an pädiatrischen und neurologischen Intensivstationen. Während bei Vorliegen einer fassbaren Semiologie die Erkennung klinisch gelingt, bedarf es für elektrographische Anfälle präziser Kriterien, welche von der Amerikanischen Klinischen Neurophysiologischen Gesellschaft (ACNS) kürzlich in einer aktualisierten Form publiziert wurden. Neue Aspekte sind hierbei die Beschreibung von kurzen potenziell iktalen rhythmischen Entladungen („brief potentially ictal rhythmic discharges“ [BIRDs]) sowie die Beschreibung des Iktal-Interiktalen-Kontinuums (IIC). Die Interpretation der elektroenzephalographischen (EEG) Kriterien erfolgt im Idealfall in einem interdisziplinären Zugang zwischen der Neurophysiologie und der Intensivmedizin. Die Korrelation von Anfallslast mit Verschlechterung des neurologischen Outcomes ist in Studien an pädiatrischen bzw. neurologischen Intensivstationen belegt.
One Dimensional Reduction of a Renewal Equation for a Measure-Valued Function of Time Describing Population Dynamics
Authors: Franco Eugenia , Gyllenberg Mats , Diekmann Odo
Published: October 2021

Despite their relevance in mathematical biology, there are, as yet, few general results about the asymptotic behaviour of measure valued solutions of renewal equations on the basis of assumptions concerning the kernel. We characterise, via their kernels, a class of renewal equations whose measure-valued solution can be expressed in terms of the solution of a scalar renewal equation. The asymptotic behaviour of the solution of the scalar renewal equation, is studied via Feller’s classical renewal theorem and, from it, the large time behaviour of the solution of the original renewal equation is derived.
Peritumoral B cells drive proangiogenic responses in HMGB1-enriched esophageal squamous cell carcinoma
Authors: Kam Ngar Woon , Wu Ka Chun , Dai Wei , Wang Ying , Yan Leo Yik Chun , Shakya Reshma , Khanna Rajiv , Qin Yanru , Law Simon , Lo Anthony Wing Ip , Lee Victor Ho Fun , Guan Xin-Yuan , Kwong Dora Lai-Wan
Published: October 2021

Several B-cell subsets with distinct functions and polarized cytokine profiles that extend beyond antibody production have been reported in different cancers. Here we have demonstrated that proliferating B cells were predominantly found in the peritumoral region of esophageal squamous cell carcinoma (ESCC). These B cells were enriched in tumor nests with high expression of high-mobility group box 1 (HMGB1). High densities of peritumoral proliferating B cells and concomitantly high intratumoral HMGB1 expression showed improved prognostic significance, surpassing prognostic stratification of ESCC patients based on HMGB1 positivity alone. This striking association led us to set up models to test whether cancer-derived HMGB1 could shape tumor microenvironment via modulation on B cells. Overexpression of HMGB1 in ESCC cell lines (KYSE510 and EC18) enhanced proliferation and migration of B cells. Transcriptomic analysis showed that migratory B cells exhibited high enrichment of proangiogenic genes. VEGF expression in proliferating B cells was induced upon co-culture of HMGB1-overexpressing tumor cells and B cells. Secretome array profiling of conditioned media (CM) from the co-culture revealed rich expression of proangiogenic proteins. Consequently, incubation of human umbilical vein endothelial cells with CM promoted angiogenesis in tube formation and migration assays. HMGB1 inhibitor, glycyrrhizin, abolishes all the observed proangiogenic phenotypes. Finally, co-injection of B cells and CM with HMGB1-overexpressing tumor cells, but not with glycyrrhizin, significantly enhanced tumor growth associated with increased microvascular density in ESCC xenograft mice model. Our results indicate that cancer-derived HMGB1 elevates angiogenesis in ESCC by shifting the balance toward proangiogenic signals in proliferating B cells.
Numerical differentiation on scattered data through multivariate polynomial interpolation
Authors: Dell’Accio Francesco , Di Tommaso Filomena , Siar Najoua , Vianello Marco
Published: October 2021

We discuss a pointwise numerical differentiation formula on multivariate scattered data, based on the coefficients of local polynomial interpolation at Discrete Leja Points, written in Taylor’s formula monomial basis. Error bounds for the approximation of partial derivatives of any order compatible with the function regularity are provided, as well as sensitivity estimates to functional perturbations, in terms of the inverse Vandermonde coefficients that are active in the differentiation process. Several numerical tests are presented showing the accuracy of the approximation.
Molecular implications of HOX genes targeting multiple signaling pathways in cancer
Authors: Shenoy U Sangeetha , Adiga Divya , Kabekkodu Shama Prasada , Hunter Keith D , Radhakrishnan Raghu
Published: October 2021

Homeobox (HOX) genes encode highly conserved homeotic transcription factors that play a crucial role in organogenesis and tissue homeostasis. Their deregulation impacts the function of several regulatory molecules contributing to tumor initiation and progression. A functional bridge exists between altered gene expression of individual HOX genes and tumorigenesis. This review focuses on how deregulation in the HOX-associated signaling pathways contributes to the metastatic progression in cancer. We discuss their functional significance, clinical implications and ascertain their role as a diagnostic and prognostic biomarker in the various cancer types. Besides, the mechanism of understanding the theoretical underpinning that affects HOX-mediated therapy resistance in cancers has been outlined. The knowledge gained shall pave the way for newer insights into the treatment of cancer.

Graphical abstract
On the Tightness of Semidefinite Relaxations for Rotation Estimation
Authors: Brynte Lucas , Larsson Viktor , Iglesias José Pedro , Olsson Carl , Kahl Fredrik
Published: October 2021

Why is it that semidefinite relaxations have been so successful in numerous applications in computer vision and robotics for solving non-convex optimization problems involving rotations? In studying the empirical performance, we note that there are few failure cases reported in the literature, in particular for estimation problems with a single rotation, motivating us to gain further theoretical understanding. A general framework based on tools from algebraic geometry is introduced for analyzing the power of semidefinite relaxations of problems with quadratic objective functions and rotational constraints. Applications include registration, hand–eye calibration, and rotation averaging. We characterize the extreme points and show that there exist failure cases for which the relaxation is not tight, even in the case of a single rotation. We also show that some problem classes are always tight given an appropriate parametrization. Our theoretical findings are accompanied with numerical simulations, providing further evidence and understanding of the results.
The Use of Children as a Tactic of Intimate Partner Violence and its Relationship to Survivors’ Mental Health
Authors: Clements Kathryn A. V. , Sprecher Mackenzie , Modica Sydney , Terrones Michelle , Gregory Katie , Sullivan Cris M.
Published: October 2021

Although prior research has established that intimate partner violence (IPV) often leads to increased depression, anxiety and post-traumatic stress disorder (PTSD), little is known about how often abusive partners and ex-partners use survivors’ children as an abuse tactic, nor whether this form of IPV also is detrimental to survivors’ mental health. The current study interviewed 299 unstably housed survivors of intimate partner violence shortly after they sought services from a domestic violence agency. All participants were parents of minor children. In-person interviews asked about abuse experienced in the prior six months, including the ways children were used as a form of IPV. Participants were also asked about their current depression, anxiety, and symptoms of PTSD. As hypothesized, the majority of parents reported their abusive partners and ex-partners had used their children as a form of IPV to control and hurt them. Further, after controlling for other forms of IPV, use of the children significantly predicted both increased anxiety and greater number of PTSD symptoms. Results show the importance of focusing on the use of children as a common and injurious form of abuse used against survivors of intimate partner violence (IPV).
Continuous and discrete-time survival prediction with neural networks
Authors: Kvamme Håvard , Borgan Ørnulf
Published: October 2021

Due to rapid developments in machine learning, and in particular neural networks, a number of new methods for time-to-event predictions have been developed in the last few years. As neural networks are parametric models, it is more straightforward to integrate parametric survival models in the neural network framework than the popular semi-parametric Cox model. In particular, discrete-time survival models, which are fully parametric, are interesting candidates to extend with neural networks. The likelihood for discrete-time survival data may be parameterized by the probability mass function (PMF) or by the discrete hazard rate, and both of these formulations have been used to develop neural network-based methods for time-to-event predictions. In this paper, we review and compare these approaches. More importantly, we show how the discrete-time methods may be adopted as approximations for continuous-time data. To this end, we introduce two discretization schemes, corresponding to equidistant times or equidistant marginal survival probabilities, and two ways of interpolating the discrete-time predictions, corresponding to piecewise constant density functions or piecewise constant hazard rates. Through simulations and study of real-world data, the methods based on the hazard rate parametrization are found to perform slightly better than the methods that use the PMF parametrization. Inspired by these investigations, we also propose a continuous-time method by assuming that the continuous-time hazard rate is piecewise constant. The method, named PC-Hazard, is found to be highly competitive with the aforementioned methods in addition to other methods for survival prediction found in the literature.
Moments of identity: dynamics of artist, persona, and audience in electronic music
Authors: Formilan Giovanni , Stark David
Published: October 2021

In our account of artistic identities among electronic music artists, we point to the notion of persona as a key element in a triadic framework for studying the dynamics of identity. Building on pragmatist theory, we further draw on Pizzorno’s concept of mask and Luhmann’s notion of second-order observation to highlight the dual properties of persona: whether like a mask that is put on or like a probe that is put out, persona is a part that stands apart. Persona is an object that alter can recognize and by which ego can be recognized; but what is recognized defies the person’s complete control. We thus conceptualize identity as a multi-sided relationship that involves person, persona, and others. Building on our ethnographic research among electronic music artists in Berlin and New York, we characterize this relationship in terms of attachment between artist and persona, between artist and audience, and between persona and audience. These attachments are variable and independent from one another. The resulting model is an analytic tool to examine identity as the ongoing outcome of the three-way dynamics of such shifting attachments. We are attentive to persona because the creation and curation of online profiles have become a pervasive element in many people’s daily interactions in both social and work situations.
Grand challenges and entrepreneurship: Emerging issues, research streams, and theoretical landscape
Authors: Ricciardi Francesca , Rossignoli Cecilia , Zardini Alessandro
Published: October 2021

This study discusses how the role of entrepreneurship in addressing the so-called “grand challenges” (e.g., poverty, inequality, pollution, climate change) is evolving and could further evolve, based on the ongoing conversation in the scholarly community. To develop the discussion, we conducted the following steps: (1) a computer-aided semantic analysis; (2) an analysis of the evolution of literature streams; and (3) a network analysis of advocated theories and approaches. All three analyses were based on a selection of 358 publications retrieved via a keyword search and 27 further publications retrieved via an analysis of five recent and relevant special issues published by important scientific journals. Our results show that the call to address grand challenges, particularly after the publication of the United Nations’ Sustainable Development Goals (SDGs), is radically transforming entrepreneurship research, with new issues emerging and replacing traditional issues as core to the discipline, marking a rapid and complex dynamics of research stream divergence and convergence. Similarly, the network of theories and approaches advocated by recent agenda-setting articles depicts an emerging theoretical landscape that is highly innovative. This new theoretical landscape revolves around systems thinking and Ostrom’s theory of the commons as the two key poles, with the embeddedness, stakeholder, institutional, effectuation, processual, and design-oriented approaches being the cross-fertilizing forces linking these two poles. In the final section, we present the nine articles included in the special issue titled “Grand Challenges and Entrepreneurship: Emerging Issues and Research Streams” and briefly synthesize these in the light of the ongoing evolution of the literature.
Photoinduced E to Z isomerization of tetraphenylethylene derivatives within organometallic supramolecular assemblies
Authors: Liu Xiao-Xu , Li Yang , Li Xin , Hahn F. Ekkehardt , Han Ying-Feng
Published: October 2021

Isolation of E-1,2-bis(4-bromophenyl)-1,2-diphenyl-ethylene from the E/Z isomer mixture obtained by a McMurry coupling reaction and reaction of this isomer with imidazole followed by N-alkylation with nBuBr and anion exchange yielded the bisimidazolium tetraphenylethylene (TPE) derivative H2-E-1(PF6)2. The reaction of H2-E-1(PF6)2 with Ag2O yielded the di-nuclear metallarectangle [Ag2(E-1)2](PF6)2 where the two bis-NHC donors E-1 bridge two silver atoms. Irradiation of [Ag2(E-1)2](PF6)2 leads to E/Z isomerization of the di-NHC ligand and formation of Z-1 in the mononuclear complex [Ag(Z-1)]PF6. Demetallation of the di-NHC ligand with NH4Cl/NH4PF6 yielded bisimidazolium salt H2-Z-1(PF6)2. The unique isomerization of the E-TPE derivative into its Z-isomer via metal complex formation/irradiation/demetallation cannot be achieved by irradiation of the individual imidazolium salt. The emissive properties of the TPE complexes [Ag2(E-1)2](PF6)2 and [Ag(Z-1)]PF6 have been investigated.
Are Veterans Getting Their Preferred Depression Treatment? A National Observational Study in the Veterans Health Administration
Authors: Leung Lucinda B. , Ziobrowski Hannah N. , Puac-Polanco Victor , Bossarte Robert M. , Bryant Corey , Keusch Janelle , Liu Howard , Pigeon Wilfred R. , Oslin David W. , Post Edward P. , Zaslavsky Alan M. , Zubizarreta Jose R. , Kessler Ronald C.
Published: October 2021

Background

Physician responsiveness to patient preferences for depression treatment may improve treatment adherence and clinical outcomes.

Objective

To examine associations of patient treatment preferences with types of depression treatment received and treatment adherence among Veterans initiating depression treatment.

Design

Patient self-report surveys at treatment initiation linked to medical records.

Setting

Veterans Health Administration (VA) clinics nationally, 2018–2020.

Participants

A total of 2582 patients (76.7% male, mean age 48.7 years, 62.3% Non-Hispanic White)

Main Measures

Patient self-reported preferences for medication and psychotherapy on 0–10 self-anchoring visual analog scales (0=“completely unwilling”; 10=“completely willing”). Treatment receipt and adherence (refilling medications; attending 3+ psychotherapy sessions) over 3 months. Logistic regression models controlled for socio-demographics and geographic variables.

Key Results

More patients reported strong preferences (10/10) for psychotherapy than medication (51.2% versus 36.7%, McNemar χ21=175.3, p<0.001). A total of 32.1% of patients who preferred (7–10/10) medication and 21.8% who preferred psychotherapy did not receive these treatments. Patients who strongly preferred medication were substantially more likely to receive medication than those who had strong negative preferences (odds ratios [OR]=17.5; 95% confidence interval [CI]=12.5–24.5). Compared with patients who had strong negative psychotherapy preferences, those with strong psychotherapy preferences were about twice as likely to receive psychotherapy (OR=1.9; 95% CI=1.0–3.5). Patients who strongly preferred psychotherapy were more likely to adhere to psychotherapy than those with strong negative preferences (OR=3.3; 95% CI=1.4–7.4). Treatment preferences were not associated with medication or combined treatment adherence. Patients in primary care settings had lower odds of receiving (but not adhering to) psychotherapy than patients in specialty mental health settings. Depression severity was not associated with treatment receipt or adherence.

Conclusions

Mismatches between treatment preferences and treatment type received were common and associated with worse treatment adherence for psychotherapy. Future research could examine ways to decrease mismatch between patient preferences and treatments received and potential effects on patient outcomes.
Numerical visualization of drop and opening process for parachute-payload system adopting fluid–solid coupling simulation
Authors: Chen Binqi , Wang Yiding , Zhao Chendi , Sun Yi , Ning Leiming
Published: October 2021

In order to study the fluid–solid coupling dynamic characteristics of parachute-payload system during drop process and analyze the unsteady aerodynamic characteristics under finite mass opening conditions, an adaptive moving fluid mesh method is developed on the basis of the existing arbitrary Lagrangian–Eulerian (ALE) fluid–solid coupling method. The calculation results of open force and drop velocity on the C-9 parachute demonstrate the effectiveness of this method. On this basis, the effect of canopies with three different permeability on parachute-payload system motion characteristic including opening property, steady descent property and stability is studied. Comparative analysis is conducted for structures and characteristics of vortex with different canopy materials, and interference mechanism of unsteady flow for parachute-payload system in unsteady oscillation is revealed. The results show that the adaptive moving fluid mesh method can effectively eliminate restrictions of existing simulation methods for parachute-payload system and significantly reduce calculation time. For the lightweight parachute, permeability has significant effect on kinetic characteristic of parachute-payload system. Canopy with large permeability has small opening load and structural stress in opening stage. After opening, there are mainly small vortexes distributed evenly behind the canopy with good stability. However, canopy with small permeability has obvious breath behavior and oscillation in opening stage. The main vortexes periodically shed off after opening. With the change of permeability from small to large, Parachute-payload system eventually presents three steady descent modes: conical descent, gliding descent and stable vertical descent.

Graphical abstract
Mostar index and edge Mostar index of polymers
Authors: Ghanbari Nima , Alikhani Saeid
Published: October 2021

Let $$G=(V,E)$$

G
=
(
V
,
E
)

be a graph and $$e=uv\in E$$

e
=
u
v
∈
E

. Define $$n_u(e,G)$$

n
u

(
e
,
G
)

be the number of vertices of G closer to u than to v. The number $$n_v(e,G)$$

n
v

(
e
,
G
)

can be defined in an analogous way. The Mostar index of G is a new graph invariant defined as $$Mo(G)=\sum _{uv\in E(G)}|n_u(uv,G)-n_v(uv,G)|$$

M
o

(
G
)

=

∑

u
v
∈
E
(
G
)

|

n
u

(
u
v
,
G
)

-

n
v

(
u
v
,
G
)

|

. The edge version of Mostar index is defined as $$Mo_e(G)=\sum _{e=uv\in E(G)} |m_u(e|G)-m_v(G|e)|$$

M

o
e

(
G
)

=

∑

e
=
u
v
∈
E
(
G
)

|

m
u

(
e
|
G
)

-

m
v

(
G
|
e
)

|

, where $$m_u(e|G)$$

m
u

(
e
|
G
)

and $$m_v(e|G)$$

m
v

(
e
|
G
)

are the number of edges of G lying closer to vertex u than to vertex v and the number of edges of G lying closer to vertex v than to vertex u, respectively. Let G be a connected graph constructed from pairwise disjoint connected graphs $$G_1,\ldots ,G_k$$

G
1

,
…
,

G
k

by selecting a vertex of $$G_1$$

G
1

, a vertex of $$G_2$$

G
2

, and identifying these two vertices. Then continue in this manner inductively. We say that G is a polymer graph, obtained by point-attaching from monomer units $$G_1,\ldots ,G_k$$

G
1

,
…
,

G
k

. In this paper, we consider some particular cases of these graphs that are of importance in chemistry and study their Mostar and edge Mostar indices.
Numerical simulation and optimization of aerodynamic uplift force of a high-speed pantograph
Authors: Dai Zhiyuan , Li Tian , Zhou Ning , Zhang Jiye , Zhang Weihua
Published: October 2021

Aiming at the problem that aerodynamic uplift forces of the pantograph running in the knuckle-downstream and knuckle-upstream conditions are inconsistent, and their magnitudes do not satisfy the corresponding standard, the aerodynamic uplift forces of pantographs with baffles are numerically investigated, and an optimization method to determine the baffle angle is proposed. First, the error between the aerodynamic resistances of the pantograph obtained by numerical simulation and wind tunnel test is less than 5%, which indicates the accuracy of the numerical simulation method. Second, the original pantograph and pantographs equipped with three different baffles are numerically simulated to obtain the aerodynamic forces and moments of the pantograph components. Three different angles for the baffles are −17°, 0° and 17°. Then the multibody simulation is used to calculate the aerodynamic uplift force of the pantograph, and the optimal range for the baffle angle is determined. Results show that the lift force of the baffle increases with the increment of the angle in the knuckle-downstream condition, whereas the lift force of the baffle decreases with the increment of the angle in the knuckle-upstream condition. According to the results of the aerodynamic uplift force, the optimal angle of the baffle is determined to be 4.75° when the running speed is 350 km/h, and pantograph–catenary contact forces are 128.89 N and 129.15 N under the knuckle-downstream and knuckle-upstream operating conditions, respectively, which are almost equal and both meet the requirements of the standard EN50367:2012.
On $$F_3(k,n)$$-numbers of the Fibonacci type
Authors: Özkan Engin , Yilmaz Nur Şeyma , Włoch Andrzej
Published: October 2021

In this paper, we study a generalization of Narayana’s numbers and Padovan’s numbers. This generalization also includes a sequence whose elements are Fibonacci numbers repeated three times. We give combinatorial interpretations and a graph interpretation of these numbers. In addition, we examine matrix generators and determine connections with Pascal’s triangle.
The teaching of computer ethics on computer science and related degree programmes. a European survey
Authors: Stavrakakis Ioannis , Gordon Damian , Tierney Brendan , Becevel Anna , Murphy Emma , Dodig-Crnkovic Gordana , Dobrin Radu , Schiaffonati Viola , Pereira Cristina , Tikhonenko Svetlana , Gibson J. Paul , Maag Stephane , Agresta Francesco , Curley Andrea , Collins Michael , O’Sullivan Dympna
Published: October 2021

Within the Computer Science community, many ethical issues have emerged as significant and critical concerns. Computer ethics is an academic field in its own right and there are unique ethical issues associated with information technology. It encompasses a range of issues and concerns including privacy and agency around personal information, Artificial Intelligence and pervasive technology, the Internet of Things and surveillance applications. As computing technology impacts society at an ever growing pace, there are growing calls for more computer ethics content to be included in Computer Science curricula. In this paper we present the results of a survey that polled faculty from Computer Science and related disciplines about teaching practices for computer ethics at their institutions. The survey was completed by respondents from 61 universities across 23 European countries. Participants were surveyed on whether or not computer ethics is taught to Computer Science students at each institution, the reasons why computer ethics is or is not taught, how computer ethics is taught, the background of staff who teach computer ethics and the scope of computer ethics curricula. This paper presents and discusses the results of the survey.