bluuebunny/crossref_metadata_2025 huggingface dataset:
”Saan tehdä mitä haluan tehdä, ainut että teen sen nyt etänä” – Työntekijöiden ja esihenkilöiden kokemuksia etäkotihoidosta
Authors: Eloranta Sini , Teeri Sari , Komulainen Marjatta , Hoffrén-Mikkola Merja , Mikkola Tuula
Published: September 2023

Tutkimuksessa kuvataan etäkotihoidon omaksumista osaksi kotihoidon palvelutarjontaa ja etäkotihoidon toteuttamista työntekijöiden ja esihenkilöiden näkökulmasta. Aineisto kerättiin keväällä 2022 kahden ison kaupungin etäkotihoidossa verkkovälitteisillä haastatteluilla. Yhteensä haastateltiin yhdeksää etäkotihoitoa toteuttavaa työntekijää ja kolmea esihenkilöä (n=12). Yksi tutkijapari haastatteli toisen kaupungin esihenkilön yksilöhaastattelulla ja työntekijät parihaastattelulla, ja toinen pari toisen kaupungin esihenkilöt parihaastattelulla ja työntekijät ryhmähaastattelulla. Aineisto analysoitiin aineistolähtöisellä sisällön analyysillä. Työntekijöiden ja esihenkilöiden aineistot yhdistettiin analyysivaiheessa.
Tulosten mukaan tekijät, jotka tukivat etäkotihoidon omaksumista ja toteuttamista osana kotihoidon palvelutarjontaa, olivat: keskitetty organisointitapa, yhteiset toimintatavat, palvelun tunnettavuuden lisääminen, kokemus palvelun hyödyllisyydestä ja työntekijöiden osaaminen.
Johtopäätöksenä voidaan todeta, että työntekijät ja esihenkilöt kokivat etäkotihoidon omaksumisen ja toteuttamisen pääosin positiivisena ja asiakkaan tilannetta hyödyntävänä.
ANTIOXIDANT DEFICIENCY AS PREECLAMPSIA RISK FACTOR
Authors: Kosilova S.Ye.
Published: September 2023

The aim – to study the state of the processes of lipid peroxidation (LPO) and theantioxidant system (AOS) of protection in pregnant women with different degrees ofpreeclampsia severity(PE).Materials and methods. LPO and AOS indicators were studied at 24-26 and 34-36 weeksof pregnancy in 20 healthy women with a physiological course of pregnancy (controlgroup) and in 34 women with PE (main group). 20 of them- with moderate PE (groupI) and 14 – with severe PE (group II).The results. When studying the processes of POL-AOS in pregnant women of all groups,a reliable increase in POL was found, which was more significant in the main group(Р˂0.001). In response to the activation of LPO processes in the control group, the activationof the AOS components of blood protection occurred, as evidenced by an increase in thelevel of glutathione (Р˂0.02) and glutathione peroxidase (Р˂0.05). This contributes to theneutralization of POL products. In pregnant women of the I group, at 24-26 weeks, the levelof glutathione and glutathione- peroxidase increased (Р˂0.02 and Р˂0.01, respectively), andat 34-36 weeks, these indicators did not differ from the control (Р>0.05). In women of theII group, against a background of an increase in the level of lipoperoxidation products, theindicator of glutathione peroxidase did not increase reliably (Р>0.05). The level of glutathionein 24-26 weeks also did not increase (Р>0.05), and in 34-36 – significantly decreased.Conclusions. In women with moderate PE at 34-36 weeks of pregnancy, there is anantioxidant deficiency and a decrease in compensatory and adaptive mechanisms.Exhaustion of the body’s antioxidant defense system was found in pregnant women withsevere PE. Violation of AOS function against a background of hyperproduction of lipidhydroperoxides can lead to oxidative stress, disruption of compensatory and adaptivemechanisms and the development of pathological conditions in the mother and fetus.Preclinical diagnosis and correction of disorders of POL-AOS processes will give anopportunity to prevent the development of severe PE.
MICROBIOLOGICAL CHARACTERISTICS OF THE LAPAROTOMIC WOUND, WHEN COMPLETE EVENTRATION BEGINNING, IN THE ONCOLOGICAL PROCESS
Authors: Morar I.K.
Published: September 2023

The aim of the study –to study the peculiarities of the qualitative and quantitative compositionof the microflora of the wound exudate of the laparotomy wound, complicated by the eventration,depending on its degree, in patients with malignant neoplasms of the abdominal cavity.Materials and methods.28 patients with malignant neoplasms of abdominal organs who hadpostoperative eventration were studied. The main group consisted of 12 patients who hada complete eventration (grade II-IV). The comparison group was formed by 16 patients whohad subcutaneous eventration (I degree). The collection of biological material was carriedout during the 8th day of the early postoperative period, by bacteriological examinationof the wound exudate, during dressings. Species composition of microorganisms, theirpopulation level, the coefficient of constancy, the frequency of species detection, thecoefficient of significance, the coefficient of quantitative dominance was studied.Results. When eventration II-IV degrees occurs, against a background of the oncologicalprocess, a probable predominance of the number of strains of E. coli, S. aureus and m/o ofthe genus Proteus is noted, and the number of strains of E. coli is likely to prevail during allperiods of observation. During the development of II-IV degrees of eventration, due to theoncological process, in the exudate of the laparotomy wound, there is a probable predominanceof the population level of E. coli, S. aureus and m/o of the genus Proteus. The dominantmicroorganism, according to the determined coefficient of quantitative dominance, at alldegrees of eventration, throughout the entire period of the study, is E. coli, and Enterococcusfaecalis is in the second place. At the same time, at all degrees of eventration, high numbers ofthe coefficient of quantitative dominance in S. aureus are noted on the 6-8th day of the study.

Conclusions. With the development of postoperative eventration of II-IV degrees, inpatients with malignant neoplasms of the abdominal cavity, a probable increase in thenumber of strains sown and the population level of microorganisms in the laparotomywound exudate with E. coli, S. aureus and microorganisms of the genus Proteus is noted.In patients with malignant neoplasms of the abdominal cavity, with the occurrence ofII-IV degrees of postoperative eventuration, the dominant microorganisms of the woundexudate are E. coli and Enterococcus faecalis and microorganisms of the genus Proteus.
Veri Olarak Kültürel Miras Koleksiyonları
Authors: DİŞLİ Meltem , TONTA Yaşar
Published: September 2023

Amaç: Günümüzde dijital insani bilimler araştırmalarında kullanılan ana veri/bilgi kaynakları dijital ortama aktarılmış çözünürlüğü yüksek belgeler ve verilerden oluşan koleksiyonlar ile bu koleksiyonlara ait makinece okunabilir ve işlem yapılabilir üstverilerdir. Bu araştırmanın amacı dijital insani bilimler araştırmacılarının “veri olarak koleksiyonlara” yönelik ihtiyaç ve beklentilerini ve kültürel bellek kurumlarının bu ihtiyaç ve beklentileri ne ölçüde karşıladıklarını saptamaktır. Yöntem: Araştırma kapsamında nitel yöntemler kullanılmış, 10 dijital insani bilimler araştırmacısı ve 16 kültürel bellek kurumu temsilcisi ile yarı yapılandırılmış görüşmeler gerçekleştirilmiştir. Araştırmacılara 20, kurum temsilcilerine 23 soru sorulmuş, tüm görüşme kayıtları çözümlenmiş (transkribe edilmiş) ve MaxQDA nitel veri analiz yazılımı aracılığıyla görüşme kayıtlarının içerik analizi yapılmıştır. Bulgular: Araştırmacılar koleksiyonlara makinece okunabilir ve işlem yapılabilir formatlarda veri setleri halinde erişmeye ihtiyaç duymaktadırlar. Protokol karşılığında veya talep olduğunda koleksiyonlarını bu şekilde paylaşabilecek az sayıda kurum olsa da henüz hiçbir kurum makinece okunabilir formatlarda ve bilişimsel erişime uygun biçimde dijital koleksiyonlarını hizmete açmamıştır. Kurumların koleksiyonlarını dönüştürmek için nitelikli personele, bütçeye, teknik altyapıya, yönetim desteğine, işbirliğine, zamana ve konuya ilişkin bir rehbere ihtiyaçları bulunmaktadır. Sonuç: Kurumlar, üstverileri düzenlemek, koleksiyonları dijitalleştirmek ve bu koleksiyonları veri olarak koleksiyon yaklaşımına uygun olarak araştırmacıların erişimine açmak için bu konuda farkındalık oluşturmalı, teknik, idari ve maddi yönlerden desteklenmeli ve nitelikli personel yetiştirmelidir. Özgünlük: Bu çalışma hem araştırmacıların hem de kültürel bellek kurumlarının bakış açılarından Türkiye’de veri olarak koleksiyonlar hizmetine yönelik gereksinimleri, beklentileri ve engelleri saptayan ilk araştırmadır.
Personnel component of the formation of the ecosystem of university development management
Authors: Dulyasova M. V. , Glazkova A. S. , Rudskaya I. A.
Published: September 2023

The objective of the work is to reveal and analyze the processes and changes in the formation of the national sovereign education system, including to consider the development and implementation of new models of university development management in a critical period for the education sector using methods of analysis and generalization. Main results: taking into account innovative processes in higher education, the functions of third–generation universities that receive their development or changed essential content in new political, demographic and economic conditions are clarified and described; elements and mechanisms for improving the effectiveness of human resources are described. On the basis of the research, the authors reasonably summarize the changing role and importance of additional vocational education to support national technological sovereignty on the basis of the updated personnel policy of universities. The material is aimed at specialists in the field of higher education and employers from among science–intensive and high–tech companies of large and medium–sized businesses.
Investigation on The Effect of Bismuth Concentration Towards Radiation Shielding Properties in Ag-embedded Borobismuthate Mixed Ionic Electronic Glass System
Authors: Hisam Rosdiyana
Published: September 2023

In this study, 20Li2O–xBi2O3–(79-x)B2O3–1Ag glasses for x=3,5,7,9, and 11 mol % glasses were prepared by using the melt quenching technique to investigate radiation shielding properties of the glasses using Phy-X/PSD simulation program at 15 keV to 15 MeV photon energy range. The radiation shielding parameters were carried out to determine the mass attenuation coefficient (MAC), linear attenuation coefficient (LAC), half value layer (HVL), mean free path (MFP) and effective atomic number (Zeff). The results showed that the Bi2O3 addition has improved overall radiation shielding properties. The MAC of the glass system was increased as Bi2O3 concentration increased. The HVL showed that present glass better than standard commercial concretes as lower HVL value indicates better shielding where 11 mol % required a much smaller thickness than 3 mol %. Therefore, sample with highest bismuth content has the most effective radiation protective property. Smaller MFP is most preferable as it suitable for protection materials; indicated the 11 mol % is best candidate for radiation shielding. Lastly, the higher value in Zeff was contributed by higher atomic number of Bi over B; thus, enhanced protection performance.
Experimental investigation of local scour under two oblong piers of a bridge crossing a sharp bend river
Authors: Abdulwahd Abdulrazaq K. , Maatooq Jaafar S.
Published: September 2023

Bridges built across a river bend and supported by more than one pier has been experimentally studied regarding the shape and nature of erosion and deposition. For this purpose, a U-shaped laboratory channel was used with two oblong piers installed at different locations. The first one was at the mid-section of the upstream straight reach, whereas in the second site within the bend, the piers have been installed at sections of central angles 0°, 30°, 60°, 90°, 120°, 150°, 170°, and 180°, from the beginning to the end of the bend segment respectively. The studies were conducted under clear water and threshold flow conditions. The results show that the higher and lower values of local scour around the pier positioned close to the outer bank, are 1.803 and 0.623 times the pier width when the bridge was installed at an angle of 90° and 30° respectively. As for the pier close to the inner bank, the deepest local scour was 1.786 times of the pier width when the bridge was installed at 60° of the bend, while the least one was 0.516 times of the pier width when the bridge was located in the 180° sector. It is worth noting that the presence of piers within sector 150 is less affected by local scour than in the other sections.
A data-driven approach to predict hydrometeorological variability and fluctuations in lake water levels
Authors: Tan Kesgin Remziye I. , Demir Ibrahim , Kesgin Erdal , Abdelkader Mohamed , Agaccioglu Hayrullah
Published: September 2023

Beyşehir Lake is the largest freshwater lake in the Mediterranean region of Turkey that is used for drinking and irrigation purposes. The aim of this paper is to examine the potential for data-driven methods to predict long-term lake levels. The surface water level variability was forecast using conventional machine learning models, including autoregressive moving average (ARMA), autoregressive integrated moving average (ARIMA), and seasonal autoregressive integrated moving average (SARIMA). Based on the monthly water levels of Beyşehir Lake from 1992 to 2016, future water levels were predicted up to 24 months in advance. Water level predictions were obtained using conventional time series stochastic models, including autoregressive moving average, autoregressive integrated moving average, and seasonal autoregressive integrated moving average. Using historical records from the same period, prediction models for precipitation and evaporation were also developed. In order to assess the model’s accuracy, statistical performance metrics were applied. The results indicated that the seasonal autoregressive integrated moving average model outperformed all other models for lake level, precipitation, and evaporation prediction. The obtained results suggested the importance of incorporating the seasonality component for climate predictions in the region. The findings of this study demonstrated that simple stochastic models are effective in predicting the temporal evolution of hydrometeorological variables and fluctuations in lake water levels.
The use of the multi-criteria analysis for the exploration of surface irrigation potential zones: A case of the Didesa sub-basin, Abay basin, Ethiopia
Authors: Tamiru Habtamu , Dinka Megersa O.
Published: September 2023

This paper presents a study conducted using the Multi-Criteria Analysis (MCA) to explore surface irrigation potential zones in the Didesa sub-basin of the Abay basin in Ethiopia. Physical land features, such as land use / land cover (LULC), slope, soil depth, drainage, and road proximity, along with climate factors like rainfall and evapotranspiration, and population density, were identified as criteria for the exploration. The analytic hierarchy process (AHP) is a powerful structured decision-making technique commonly used for complex multi-criteria analysis problems where multiple criteria need to be considered. The importance of the criteria was prioritised and ranked in the analytic hierarchy process (AHP). Five qualitative-quantitative based surface irrigation potential zones were identified, namely highly suitable (48.40%), moderately suitable (27.26%), marginally suitable (13.27%), not suitable (4.91%), and irrigation constraints (6.16%). The consistency of the AHP technique in the exploration of surface irrigation potential zones is evaluated by the consistency index at CI = 0.011 and confirmed the correctness of weights assigned for the individual key factor in the AHP. The accuracy of the potential zones generated in the AHP was evaluated with ground-truth points and a supervised LULC classification map. Moreover, a good agreement was made among the classes with the kappa index ( KI = 0.93). Therefore, the application of the MCA for the exploration of surface irrigation potential zones was successful, and the results of the study will be useful to strengthen the irrigation in the explored potential zones.
Assessment of the Probability of Exceeding the Limiting Deformations of a Building Foundation
Authors: Kichaieva Oksana , Adam Dietmar
Published: September 2023

The level of ground settlement under the effect of certain factors is one of the markers indicating the adequacy of adopted design solutions. By comprehending settlement values, it is possible to infer the degree of risk associated with a project and, if necessary, introduce changes to the design. The concept of reliability management here manifests itself in the timely adjustment of the decisions made, while it is necessary to use the procedure of the quantitative assessment of the probability of the occurrence of a particular limit state. A qualitative assessment indicates only the limits of an area, which approximately characterizes the effects of changes in the geotechnical situation. In this article, a method for determining the probability of exceeding the limit deformation of a building-base massif using the Monte Carlo statistical method is developed, and an algorithm and computer program implementing the proposed calculation method are created.
Serbian Translation and Validation of the SF-36 for the Assessment of Quality of Life in Patients with Diagnosed Arterial Hypertension
Authors: Nikolic Aleksandra , Biocanin Vladimir , Rancic Nemanja , Duspara Mirjana , Djuric Dusan
Published: September 2023

Precise estimation of life quality is of special importance in patients with chronic diseases, such as arterial hypertension. There are many questionnaires for that purpose. Short-form 36 (SF-36) with 8 domains has been proved as one of the most appropriate. To date, there was no translated and validated SF 36 in Serbian language for hypertensive patients. The aim of this study was to test validity and reliability of SF-36 in Serbian patients with diagnosed arterial hypertension. Cronbach’s alpha coefficient was calculated to assess the internal consistency of the Serbian version of the SF-36. After deducting the overlap between each of the 36 items and its related domain, the collective validity was considered to be good if the correlation coefficient remains > 0.4. Only 2.54% answers on the questions were missing. Values of all the 8 domains were higher in men than in women. Cronbach alpha coefficient was high for SF-36, 0.897, and it suggesting that the SF-36 had good internal reliability. All 8 domains showed high values non-rotating factorial weights (>0.300) (range from 0.742-0.856), and all measure the same thing. It means that all components in this questionnaire measure the things they are assigned to.
Molecular Docking Analysis of Novel Thiourea Derivatives of Naproxen with Potential Antitumor Activity
Authors: Nedeljkovic Nikola , Dobricic Vladimir , Mijajlovic Marina , Vujic Zorica , Nikolic Milos
Published: September 2023

Naproxen, as a propionic acid derivative, causes serious gastrointestinal side effects due to the presence of free carboxylic group. In that sense, masking of carboxylic group with other pharmacophores may be a promising strategy to decrease gastrointestinal toxicity. Thiourea derivatives have been intensively investigated as potential antitumor drugs, whereby their activity is based on potential inhibition of protein kinases, topoisomerases, carbonic anhydrase and sirtuins. In addition, it was shown that inhibition of certain protein kinases might reverse resistance to chemotherapeutic drugs by enhancing the cell death in the presence of low concentrations of drug. Twenty new thiourea derivatives of naproxen were designed and their binding to four selected protein kinases involved in tumor multidrug resistance (AKT2, mTOR, EGFR and VEGFR1) was estimated using two molecular docking programs (AutoDock Vina and OEDocking). According to OEDocking, the highest potential to inhibit AKT2 and mTor has derivative 1, while derivative 20 demonstrates the highest potential towards EGFR and VEGFR1. According to AutoDock Vina, the highest potential for inhibition of EGFR, AKT2 and VEGFR1 have derivatives 16 and 17. Therefore, derivatives 1, 16, 17 and 20 are potentially the most potent protein kinase inhibitors that could be further synthesized and tested for anticancer activity.
Obstetric Violence in Developing Health Systems: An Evolving Problem Requiring Novel Intervention
Authors: Pomfret Jayson , Brustolin Anna Luiza
Published: September 2023

While the term obstetric violence has a variable definition given its immensely personal and internally compassionate nature; many accept it to mean: harm inflicted during or in relation to pregnancy, childbearing, and the post-partum period often on the part of a healthcare provider. Obstetric violence, an enigmatic and labyrinthine concern, predominantly and disproportionality affects those experiencing pregnancy in nations with developing healthcare frameworks. The specific comparison that this article will explore is Canada versus Brazil. Due to sociopolitical factors that are beyond the scope of this article, Canada is often seen as a strong representation of developed healthcare whereas Brazil is often placed within the context of developing or underserved as it pertains to healthcare access and development. This is further reinforced by statistical rankings which in 2020 placed Canada as the 15th most developed healthcare system and Brazil ranked at 70.
¿Cómo se ha comprendido la salud mental en la infancia? Revisión sistematizada 2001-2022
Authors: Rivera Pulido Yudy
Published: September 2023

La salud mental ha sido comprendida desde diferentes áreas del conocimiento y su estudio se ha enfocado en algunos grupos poblacionales como adolescentes, jóvenes y adultos. Sin embargo, en lo que se refiere a la infancia la información que circula es más escasa. Con el objetivo de describir las comprensiones, definiciones y/o significados que se han otorgado a la salud mental en la infancia se planteó la pregunta de cómo ésta ha sido comprendida. Esta revisión sistematizada incluyó artículos de investigación publicados entre 2001 y 2022. Como resultado, se encontró una tendencia a comprender la salud mental desde la presencia y/o ausencia de signos y síntomas definidos tanto para adultos como para los niños y niñas y el uso de estadísticas de prevalencia de trastornos mentales para enfatizar la necesidad de investigar acerca de la salud mental en edades tempranas. Se concluye que las comprensiones de salud mental en la infancia incluyen elementos de las definiciones generales en salud mental

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Mental health has been understood from different areas of knowledge and its study has focused on some population groups such as adolescents, young people and adults. However, as far as childhood is concerned, the information that circulates is scarcer.  With the aim of describing the understandings, definitions and/or meanings that have been given to mental health in childhood, the review question How has mental health in childhood been understood? This systematized review included research articles published between 2001 and 2022. As a result, we found a tendency to understand mental health from the presence and/or absence of signs and symptoms defined for both adults and children and the use of prevalence statistics of mental disorders to emphasize the need for research on mental health at early ages. It is concluded that understandings of mental health in childhood include elements of general definitions of mental health.
Cambios en el comportamiento de niños, niñas y adolescentes víctimas de violencia intrafamiliar
Authors: Piantino Dias Emerson , Regis Duarte Karinne
Published: September 2023

La violencia intrafamiliar contra niños, niñas y adolescentes es un problema de salud pública que puede tener graves consecuencias para el desarrollo físico y emocional. El objetivo de la investigación es describir la tipificación de la violencia contra niños, niñas y adolescentes, así como conocer los recursos utilizados por los profesionales de la salud para identificar marcas físicas y psicológicas provocadas por la violencia en esta población. Se trata de una investigación cualitativa en la que se utilizó el análisis de contenido según la propuesta de Bardin. Fueron entrevistados 14 profesionales de la salud de dos equipos de la Estrategia de Salud de la Familia, en la ciudad de Uberlândia, Brasil. El estudio permitió comprender las experiencias de los profesionales en la detección de manifestaciones que evidencian la presencia de violencia intrafamiliar practicada contra niños, niñas y adolescentes.

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Domestic violence against children and adolescents is a serious public health problem that can have serious consequences for physical and emotional development. The objective of the research is to describe the typification of violence against children and adolescents as well as to know the resources used by health professionals to identify physical and psychological marks caused by violence in this population. This is qualitative research using Content Analysis, according to Bardin's proposal. Fourteen health professionals from two teams of the Family Health Strategy were interviewed, in the city of Uberlândia, Brazil. The study made it possible to understand the experiences of professionals in the detection of manifestations that show the presence of domestic violence practiced against children and adolescents
Vulnerabilidad/soledad común. Judith Butler y Jorge Alemán
Authors: Muniagurria Mandela Indiana
Published: September 2023

El artículo se interroga acerca de lo común como esa persistente zona que disgrega, ensambla y también contamina los límites entre lo subjetivo y lo social, y lo hace a partir de las perspectivas de Judith Butler –especialmente en sus escritos de los años dos mil– y de Jorge Alemán en su Soledad: Común. Políticas en Lacan. Se sostiene que, a pesar de la inscripción en tradiciones teóricas distintas y hasta en disputa, ambas lecturas parten de un gesto curiosamente similar: identificar la opacidad constitutiva del sujeto como la piedra angular para pensar la experiencia política de lo común. El escrito propone situar, en el corazón de las dos interpretaciones, una tensión entre, por un lado, el horizonte posfundacional en el que suelen ser inscriptas y, por el otro, sus derivas político-normativas.

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The article interrogates the notion of “common” as that persistent zone that disintegrates, assembles and also contaminates the limits between the subjective and the social, based on an analysis of the perspectives of Judith Butler –especially in her 2000s writings– and Jorge Alemán in his Solitude: Common. Politics in Lacan. It is argued that, despite the inscription in different and even disputed theoretical traditions, both readings start from a curiously similar gesture: by identifying the constitutive opacity of the subject as the cornerstone for thinking the political experience of the common. The article proposes to situate, at the center of the two interpretations, a tension between, on the one hand, the post-foundational horizon in which they are usually inscribed and, on the other, their political-normative drifts
PELATIHAN LITERASI MODEL PEMBELAJARAN BERBASIS PROYEK (PROJECT BASED LEARNING) SEBAGAI UPAYA PENINGKATAN PROFESIONALISME GURU DI KABUPATEN GARUT
Authors: Mulyati Yeti , S. Damayanti Vismaia , Sastromiharjo Andoyo , Hidayatullah Asep , Permana Indra , Sulaiman Zoni , Sari Faradilla Intan
Published: September 2023

Pemahaman mengenai model pembelajaran berbasis proyek sangat penting dalam mendukung keterampilan siswa pada kurikulum merdeka belajar. Permasalahan prioritas guru mata pelajaran bahasa Indonesia yang terhimpun dalam organisasi MGMP bahasa Indonesia di Kabupaten Garut adalah kurangnya pemahaman terhadap model pembelajaran. Hal tersebut terbukti dari hasil kuesioner, rata-rata peserta tidak mengetahui secara komprehensif mengenai model pembelajaran berbasis proyek. Solusi yang ditawarkan untuk mengatasai permasalahan pada mitra adalah dengan pemberian materi awal yang meliputi materi tentang konsep dasar, karakteristik, tujuan, keunggulan, kelemahan, dan tahapan atau alur model pembelajaran berbasis proyek (Project Based Learning). Langkah selanjutnya, peserta melakukan simulasi pelaksanaan model pembelajaran berbasi proyek yang meliputi: (1) orientasi peserta didik pada masalah; (2) mengorganisasikan peserta didik untuk belajar; (3) membimbing penyelidikan individu maupun kelompok; (4) Mengembangkan dan menyajikan hasil karya; dan (5) menganalisis dan mengevaluasi proses pemecahan masalah, dan diakhiri dengan mendiskusikan kompetensi dasar kelas X, XI, dan XII yang relevan disampaikan menggunakan model pembelajaran berbasis proyek (project Based Learning). Melalui metode tersebut, pemahaman model pembelajaran berbasis proyek peserta meningkat yang dibuktikan melalui tugas yang telah dikerjakan.
Dermatological Adverse Effects of Covid-19 Vaccine among Healthcare Workers: Findings from a Tertiary Care Hospital in Northern India
Authors: Choudhary Harshita , Wason Rhea , Goel Madhav , Relhan Vineet , Majhi Madan Mohan
Published: September 2023

Objectives:

The objective of this study was to identify the cutaneous manifestations that developed after covid-19 vaccination, with Covaxin and Covishield, in healthcare workers (HCW) and to identify any associated factors.

Materials and Methods:

A cross-sectional study was conducted over 3 months using an online and offline questionnaire that was circulated among the HCW working at a tertiary care hospital in Delhi. All the vaccinated HCWs who gave consent (n = 676) (n = number of participants) were included in the study. Data were summarised in an excel sheet and then analysed using SPSS, version 25.

Results:

Out of the 676 vaccine recipients, a higher number of participants were vaccinated with Covishield compared to Covaxin. Only 14 (2.0%) subjects developed new adverse dermatological manifestations following either vaccination. A higher incidence of adverse reaction was observed with Covaxin than with Covishield, but the difference was not significant. A significantly higher number of vaccinated paramedical workers developed new dermatological manifestations in the study period [P-value (probability value)] (P = 0.018).

Conclusion:

Our study demonstrated a low rate of cutaneous adverse reactions following vaccination with either Covaxin or Covishield. Further studies are hence needed to corroborate our findings.
The effect of epidural steroid injection during surgery on surgical site infections following lumbar fusion
Authors: Eltoukhy Mohamed , Eldabaa Karim , Eissa Mohamed Ahmed
Published: September 2023

Background:

Intraoperative epidural steroid injections (ESIs) have been suggested to limit pain following lumbar fusions. However, the frequency of resultant surgical site infections has not been fully investigated.

Methods:

We retrospectively followed two groups of patients; 23 patients were the control group, while the other 23 patients received, in addition to the spinal fusions, intraoperative ESI.

Results:

Patients in the latter ESI/fusion treatment group had significantly increased rates of superficial and deep infections (i.e., superficial infections 17.4% and 4.3% deep infections) versus control patients (i.e., 8.6% superficial and 0% deep) undergoing fusions alone.

Conclusion:

We observed an increased risk of postoperative surgical site infections among patients who underwent intraoperative ESI in addition to their lumbar fusions.
Artificial Intelligence in Oncology: The Wins, The Challenges, and How We Can Deliver on Personalized Cancer Care
Authors: Biancalana Matthew , Pandey Tushar
Published: September 2023

The development of effective, targeted therapies for cancer remains one of the primary goals in precision medicine, requiring the input of multiple disciplines across the diagnostic and therapeutic landscape. Despite the signifi­cant role of cancer care in medicine, there is a forecasted shortfall of physicians able to diagnose and treat patients along their cancer diagnosis journey, which is only projected to worsen in the coming decades. Artificial intelligence (AI), and its manifestations in both machine learning and deep learning, are poised to un­burden physicians from many laborious and repetitive tasks in diagnostic anal­yses, while also providing insight into prospective therapeutic options. AI will increasingly facilitate decision-making as well as improve the accuracy and rel­evance of therapeutic recommendations. This collaborative interaction between algorithms and physicians promises to enhance the field of precision medicine and further enable optimal patient care.
Competing for Temporary Advantage in a Hypercompetitive Mobile App Market
Authors: James Tabitha , Qiao Zhilei , Shen Wenqi , Wang G. Alan , Fan Weiguo
Published: September 2023

Hypercompetitive mobile app stores are characterized by rapid innovation and intense competition. App firms must vie for temporary competitive advantage through competitive actions such as releasing product improvements. We study how competitive indicators influence a particular competitive action—app updates—in a mobile game app market. Our results reveal that app firms take action to improve or sustain their temporary competitive advantage, updating their apps when there are opportunities to capitalize on popularity (e.g., rank and rating volume are increasing) and when their apps’ advantages are threatened (e.g., customer ratings are decreasing). We also find that app updates are released in response to competitors’ actions—specifically, when competitors update their apps and new competitors enter ranking lists. Moreover, our findings show that app firms release app updates when an app’s customer rating volume is increasing or when an app firm’s portfolio of game apps is less diverse, relative to its competitors. We conduct additional analyses that show that older app firms are responsive to more competitive indicators than younger ones and major updates are primarily used to respond to serious threats to apps’ competitive positions. Overall, our results indicate that app updates are competitive actions used to improve or sustain temporary advantage when competitive indicators reveal opportunities to improve or threats to apps’ competitive positions.
Building a Reputation as a Business Partner in Information Technology Outsourcing
Authors: Kotlarsky Julia , Rivard Suzanne , Oshri Ilan
Published: September 2023

One noticeable trend in the maturing information technology (IT) outsourcing industry is the growing interest from client firms seeking to benefit from supplier-led innovations. Yet IT outsourcing suppliers still find it challenging to shift their reputation from the competent provision of a low-end service to a high-value innovative line of services, thus becoming known as business partners. We address this issue by examining the reputation formation efforts of an IT supplier experiencing a reputation deficit in terms of quality (its ability as a business partner) and intent (its intention to adopt trustworthy behavior). We develop a model based on a case study of a large IT supplier engaged in reputation formation with its outsourcing clients. We portray reputation formation as a process wherein an IT supplier alternately emits signals of quality and intent from a repertoire of signals. Our process model distinguishes between signaling at the market level, which relies on rhetorical mediums to broadcast a message promoting the supplier’s ability as a business partner, and signaling at the client level, which relies on substantive mediums such as demonstrations of the supplier’s ability to solve the client’s business problems and behavioral mediums that allow the client to assess the supplier’s intent to adopt trustworthy behavior.
From Bits to Atoms: Open Source Hardware at CERN
Authors: Priego Laia Pujol , Wareham Jonathan
Published: September 2023

Although considered a relatively recent phenomenon of the past decade, open source hardware (OSH) is already influencing commercial hardware development. However, a common belief is that the greater economic cost and complexity of hybrid digital objects (i.e., digital objects with both hardware and software) precludes their development with open source methods traditionally used for software. We study a sophisticated OSH named White Rabbit initiated at CERN and developed through a vibrant and heterogenous open source community. Our findings show that the assumption that hardware and software require fundamentally distinctive development and production modes should be replaced with a more nuanced differentiation characterized by three main attributes describing an object’s composition: embodiment, modularity, and granularity. Taken together, these three attributes determine how a hybrid object is developed throughout its evolution in an open source community. Our research offers several contributions. First, we provide a more nuanced view of the consequences of the material embodiment of hardware. Once considered a simple deterrent to open source development, we describe how economic cost is subordinate to more influential aspects of an object’s physical layers: as the open source community modifies the object to accommodate the operating requirements of diverse physical instantiations, such modifications can be incorporated in the logical design covered by the open source license. Additionally, we show how embodiment, modularity, and granularity progress through the object’s evolution and how this maturation subsequently affects development modes. We trace the implications of our findings for hybrids and digital object conceptualizations in IS research, open source development and, more broadly, normative implications for OSH in scientific and commercial computing.
ROLEX: A Novel Method for Interpretable Machine Learning Using Robust Local Explanations
Authors: Kim Buomsoo (Raymond) , Srinivasan Karthik , Kong Sung Hye , Kim Jung Hee , Shin Chan Soo , Ram Sudha
Published: September 2023

Recent developments in big data technologies are revolutionizing the field of healthcare predictive analytics (HPA), enabling researchers to explore challenging problems using complex prediction models. Nevertheless, healthcare practitioners are reluctant to adopt those models as they are less transparent and accountable due to their black-box structure. We believe that instance-level, or local, explanations enhance patient safety and foster trust by enabling patient-level interpretations and medical knowledge discovery. Therefore, we propose the RObust Local EXplanations (ROLEX) method to develop robust, instance-level explanations for HPA models in this study. ROLEX adapts state-of-the-art methods and ameliorates their shortcomings in explaining individual-level predictions made by black-box machine learning models. Our analysis with a large real-world dataset related to a prevalent medical condition called fragility fracture and two publicly available healthcare datasets reveals that ROLEX outperforms widely accepted benchmark methods in terms of local faithfulness of explanations. In addition, ROLEX is more robust since it does not rely on extensive hyperparameter tuning or heuristic algorithms. Explanations generated by ROLEX, along with the prototype user interface presented in this study, have the potential to promote personalized care and precision medicine by providing patient-level interpretations and novel insights. We discuss the theoretical implications of our study in healthcare, big data, and design science.
The edge between regional and exploratory work in ethnological expertise
Authors: Sivtsev A. I. , Sleptsov A. N. , Sivtsev N. A.
Published: September 2023

Recently, there has been an urgent need to accelerate exploration for oil and gas in Eastern Siberia, including the Sakha Republic (Yakutia). The need is due to the reversal of the country’s energy industry in the eastern direction due to the illegal sanctions of a number of Western countries. For territories with complex transport logistics and difficult climatic conditions, one of the main factors of the success of geological exploration is the availability of sufficient time to fulfill the planned plans. Using the example of the regional law “On ethnological expertise in places of traditional residence and traditional economic activity of indigenous small-numbered peoples of the North of the Sakha Republic (Yakutia)”, the risks of non-fulfillment of license obligations by subsoil users are shown. Seismic exploration works are considered as the main tools for regional justification, areal prospecting and preparation of objects of exploratory drilling for oil and gas. It is noted that in areas with weak seismic exploration studies, the exploratory stage of geological exploration has the characteristics and scope of the regional stage of work. The main criterion for the regional understudy of promising oil and gas territories is proposed to accept a low density of seismic observations. For promising territories with seismic exploration studies with a profile density of less than 0.2 km/km2, it is proposed to make a relaxation in the form of exemption from passing an ethnological examination in places of traditional residence and traditional economic activity of indigenous small-numbered peoples of the North in the Sakha Republic (Yakutia) regardless of whether they are carried out on a state assignment or at the expense of the subsoil users’ own funds.
New insight into the electrochemical CO2 reduction reaction: radical reactions may govern the whole process
Authors: Sun Youyi
Published: September 2023

In present paper, we wish to suggest a reaction mechanism for the electrochemical reduction of carbon dioxide. This mechanism can provide a reasonable interpretation to the formation of widely range of products on copper catalyst.
Chemical Biology Reveals Involvement of N-acetylglucosaminidase LytG In Cell Elongation and Division.
Authors: Hernandez Jazmeen , Duval Jett , Rauff Taryn , Hall Ethan , Gallati Mika , Haubrich Brad , Thoma Monica , Aponte Elimelec , Basu Amit , DeGiorgis Joseph A. , Reid Christopher
Published: September 2023

The growth and division of the Gram-positive cell requires the coordinated action of enzymes involved in the synthesis and degradation of the heteropolymer peptidoglycan. Herein, we present the use of the diamide Masarimycin, an inhibitor of the exo-N-acetylglucosaminidase (GlcNAcase) LytG, as a chemical biology probe to elucidate biological role of this cell wall degrading enzyme. Using a combination of chemical biology and genetic approaches we provide the first evidence that LytG activity influences the elongation and division complexes in Bacillus subtilis. Chemical inhibition of LytG results in dysregulated cell elongation and localization of division plane and the induction of the cell wall stress response. In the presence of masarimycin, cells are elongated 3-fold compared to wild-type cells and formation of daughter cells along the sidewall was observed. The use of genetic and synergy/antagonism screens established connections to late-stage peptidoglycan synthesis, particularly related to cross-linking function. These results stand in stark contrast to those observed for the lytG knockout, which does not exhibit these phenotypes. The results presented here emphasize the difficulty in assigning mode-of-action using solely genetic screens. This is the first report of assigning physiological role of LytG beyond being the major GlcNAcase during vegetative growth.
Influence of fluorescence lifetime selections and conformational flexibility on brightness of FusionRed variants
Authors: Mukherjee Srijit , Douglas Nancy , Jimenez Ralph
Published: September 2023

Fluorescent Proteins (FPs) for bioimaging are typically developed by screening mutant libraries for clones with improved photophysical properties. This approach has resulted in FPs with high brightness, but the mechanistic origins of the improvements are often unclear. We focused on improving the molecular brightness in the FusionRed family of FPs with fluorescence lifetime selections on targeted libraries, with the aim of reducing non-radiative decay rates. Our new variants show fluorescence quantum yields up to 75% and lifetimes >3.5 ns. We present a comprehensive analysis of these new FPs, including trends in spectral shifts, photophysical data, photostability, and cellular brightness resulting from codon optimization. We also performed all-atom molecular dynamics simulations to investigate the impact of sidechain mutations. The trajectories reveal that individual mutations reduce the flexibility of the chromophore and sidechains, leading to an overall reduction in non-radiative rates.
Compound specific isotope analysis to evaluate in situ transformation of a complex mixture of substituted chlorobenzenes in a pilot constructed wetland system
Authors: Suchana Shamsunnahar , Lomheim Line , Edwards Elizabeth , Quintero Paola Barreto , Mack Elizabeth Erin , Mancini Silvia , Passeport Elodie
Published: September 2023

Constructed wetlands can be a suitable remediation technique for the treatment of industrial contaminants via transfer (i.e., non-destructive) and transformation (i.e., destructive) processes. Providing direct evidence of in situ transformation using concentrations and biogeochemical parameters alone is challenging. Compound specific isotope analysis (CSIA) is a widely used tool to assess in situ transformation of contaminants based on changes in their stable isotope signatures. In this work, we evaluated the potential of CSIA to identify and possibly quantify the in situ transformation of six NO2- and NH2-chlorobenzenes in complex aqueous samples from a pilot constructed wetland system. No significant changes in δ13C, i.e., ≤2‰ were observed for any of the target compounds despite the contaminant concentration decreased by more than 99% between the inlet and outlet of the system. Using multi-element CSIA of carbon, hydrogen, and nitrogen and laboratory-derived isotope enrichment factors, we successfully identified and quantified the extent of in situ transformation of 2,3-dichloroaniline (2,3-DCA) in the pilot constructed wetlands. The isotopic trends provide evidence for aerobic biotransformation as a dominant pathway in the surface flow planted wetlands; whereas sorption was identified as the likely process in planted and unplanted upflow gravel bed wetlands during the initial wetland operation periods. Another major contaminant from the NO2-chlorobenzene group, i.e., 2-chloronitrobenzene (2-CNB), showed negligible δ13C, and small δ2H (±20‰) and δ15N (±2‰) isotope fractionation. No laboratory-controlled CSIA studies are yet available for 2-CNB biotransformation to characterize transfer and transformation processes. This study highlights the applicability of CSIA as a quantitative tool for 2,3-DCA in dynamic environmental conditions of wetlands and the need for pathway-specific isotope enrichment factors for the successful CSIA application of other target compounds.