bluuebunny/crossref_metadata_2025 huggingface dataset:
Paeonol alleviates migration and invasion of endometrial stromal cells by reducing HIF-1α-regulated autophagy in endometriosis
Authors: Pang Conghui , Wu Zhijuan , Xu Xiaoyan , Yang Wenxiu , Wang Xiaoxuan , Qi Yinghua
Published: September 2021

Background: Dysregulated migration and invasion of endometrial stromal cells is implicated in the pathogenesis of endometriosis. Hypoxia functions as critical microenvironmental factor that results in promotion of endometrial stromal cells migration and invasion through up-regulation of autophagy. Paeonol functioned as a tumor suppressor in human ovarian cancer and promoted cytoprotective autophagy. However, the role of paeonol in hypoxia-induced autophagy in endometriosis remains unknown. Methods: Stromal cells were isolated from endometriotic patients by enzymatic digestion of ectopic endometrial tissues, and then characterized by immunohistochemical analysis of cytoskeleton 19 (CK19) and vimentin. Cellular morphology was evaluated under microscope. Cell viability, proliferation and apoptosis of stromal cells were assessed by Cell Counting Kit-8, EdU labeling and flow cytometry, respectively. Wound healing and transwell assays were performed to detect metastasis of the stromal cells. Hypoxia-induced autophagy was evaluated through immunohistochemistry and western blot. Results: Paeonol treatment dosage dependently decreased cell proliferation and metastasis of the ectopic endometrial stromal cells (ecESCs), while promoted the cell apoptosis. Hypoxia-induced autophagy in the ecESCs was repressed by paeonol through down-regulation of LC3-II/LC3-I and Beclin-1, while up-regulation of p62. Hypoxia-inducible factor-1α (HIF-1α) was reduced post paeonol treatment, and paeonol-induced increase of p62 and decrease of LC3-II/LC3-I and Beclin-1 were reversed by over-expression of HIF-1α. Over-expression of HIF-1α also attenuated the suppressive effect of paeonol on cell growth of ecESCs. Conclusions: Paeonol attenuated HIF-1α-induced promotion of ecESCs migration and invasion through reducing autophagy, and reduced HIF-1α-induced endometriotic lesion in rats, providing potential therapeutic strategy for the treatment of endometriosis.
Influences of blood flow parameters on temperature distribution during liver tumor microwave ablation
Authors: Wang Jinying , Wu Shuicai , Wu Zeyi , Gao Hongjian , Huang Shengyang
Published: September 2021

Highlights: (1) A 3D simulation model of MWA (microwave ablation) based on the temperature-dependent characteristic parameters and blood flow parameters was established to realize the visual simulation of temperature distribution and coagulation zone. The internal forced convection condition was used to accurately characterize the large vessel. (2) The ex vivo MWA experimental platform was built to verify the accuracy of the simulation model. A peristaltic pump was employed for operatively controlling blood circulation and a medical soft plastic tube was introduced for appropriately simulating a blood vessel. (3) The influences of blood flow parameters of large vessels on temperature distribution and coagulation zone were systematically analyzed in order to provide reference and guidance for MWA clinicians. Purpose: Clinical MWA of liver tumor is significantly limited by the accurate prediction of vascular cooling effects. To provide reference and guidance for clinical MWA of liver tumor, the three-dimensional effects of different blood flow parameters of large vessels on MWA temperature distribution were systematically evaluated. Materials and methods: Firstly, the MWA three-dimensional finite element simulation model with blood flow parameters was established. Secondly, to verify the effectiveness of the model, MWA was performed ex vivo in porcine liver for 360 s and the temperature was measured by thermocouples. A medical soft plastic tube was placed parallel to the MWA antenna to simulate a natural liver vessel. Finally, based on this model, the influences of different vessel diameters and vessel-antenna spacings on MWA temperature distribution were analyzed. Results: Sixteen ablations were performed to verify the accuracy of the simulation model. The mean temperature errors between measured data and simulation results at six measurement points were 3.87 ℃. In the first 10 seconds of MWA, the vessel cooling effect on temperature distribution was negligible. When the vessel-antenna spacing was 5 mm and the vessel diameter varied from 3 mm to 6 mm, the temperature at the measured point near the vessel decreased by 2.11 ℃ at 360 s. When the vessel diameter was 6 mm and the vessel-antenna spacing varied from 5 mm to 7 mm, the temperature at the measured point near the vessel reduced by 14.91 ℃ at 360 s. In addition, blood diameter had little influence on the temperature distribution near the heating point. The volume of coagulation zone will not be obviously affected once the vessel lies outside the predicted coagulation zone. Conclusions: The MWA simulation model with blood flow parameters is established. Vessel-antenna spacing is the primary factor affecting the temperature distribution. A vessel with larger diameter can have a more significant effect on the temperature distribution. The large vessel will take away and block part of conduction heat, so the coagulation zone will not be formed on the lateral side of the vessel.
PLA-based core-shell structure stereocomplexed nanoparticles with enhanced loading and release profile of paclitaxel
Authors: Wang Yuemin , Cui Siyuan , Wu Bing , Zhang Quanxing , Jiang Wei
Published: September 2021

Purpose: In the present study, to achieve high paclitaxel (PTX) loading in a conjugated drug delivery system with minimal long-term side effects, we formulated a novel degradable stereocomplexed micelle-like particle with a core-shell structure. Materials and methods: In this system, methoxy polyethylene glycol (MPEG) acted as the hydrophilic shell, and the stereocomplex of polylactic acid with PTX (SCPLA-PTX) acted as the hydrophobic core. The MPEG-SCPLA-PTX micelle-like particles were synthesized via the self-assembly of a MPEG-poly L-lactic acid (PLLA) copolymer with a PTX-poly D-lactic acid-PTX copolymer. The resultant copolymers and their intermediates were characterized using 1H nuclear magnetic resonance and GPC. Micelle-like particles with different molecular weight ratios of MPEG and PLLA were synthesized to demonstrate the functions of both components. Results: PTX loading into MPEG2000Da-PLLA6000Da particles reached as high as 20.11%. At 216 h, the cumulative release from MPEG5000Da-PLLA6000Da, MPEG2000Da-PLLA6000Da, and MPEG5000Da-PLLA22000Da particles were 51.5%, 37.7%, and 52.0%, respectively. Conclusions: According to the cell uptake experiments, inhibition of tumor cell growth was satisfactory, indicating that the stereocomplexed particles developed in the present study can be employed as a promising nanocarrier for PTX delivery.
Effects of selenium application on biochemical characteristics and biofortification level of kohlrabi (Brassica oleracea L. var. gongylodes) produce
Authors: Antoshkina Marina , Golubkina Nadezhda , Sekara Agnieszka , Tallarita Alessio , Сaruso Gianluca
Published: September 2021

Background: Biofortification of vegetables with selenium (Se) greatly depends on species tolerance to Se supply. Due to the scant information regarding kohlrabi Se biofortification, the aim of the present work was the evaluation of foliar sodium selenate application on yield and biochemical characteristics of three kohlrabi cultivars. Material and methods: A two years field experiment was conducted in Moscow region (Russia) on 3 kohlrabi cultivars using foliar biofortification with Na2Se04 solutions (50, 75 and 100 mg/L) and subsequent biochemical analysis of roots, stems and leaves. Results: Out of the three concentrations tested (50, 75 and 100 mg/L) plus an untreated control, the Se 75 dose demonstrated the strongest growth stimulation effect resulting in the increase of stem weight (by 1.35–1.61 times), yield (1.37–1.66 times), monosaccharide (1.59–2.24 times), ascorbic acid (1.54–2.01 times) and total phenolic levels (by 1.23–1.37 times), compared to the untreated control. The biofortification values varied from 69.4 (White Vienna 1390) to 59.9 (Dobrynya F1 hybrid) and 43.6 (Sonata F1 hybrid) under the Se dose of 100 mg/L. The maximum Se content in kohlrabi stems reached 4.40 mg/kg d.w. for Sonata F1, 3.53 mg/kg d.w. for Dobrynya F1 hybrids and 5.20 mg/kg d.w. for cultivar White Vienna 1390. Significant correlations were revealed between Se and total phenolics (0.720; p < 0.002), ascorbic acid (0.842; p < 0.001), monosaccharides (0.898; p < 0.001) and total sugar (0.764; p < 0.001). No significant changes in nitrate levels and dry matter content were recorded as the result of Se supply. Conclusion: The outcomes of the present research demonstrated the high benefits of Se application in improving kohlrabi yield and nutritional quality.
Foliar pathogen-induced assemblage of beneficial rhizosphere consortia increases plant defense against Setosphaeria turcica
Authors: Zhu Lin , Wang Songhua , Duan Haiming , Lu Xiaomin
Published: September 2021

Background: Foliar pathogen infection can induce the enrichment of beneficial microbial consortia in plant rhizosphere, but the mechanism for enhanced plant resistance is unclear. Methods: We investigated the effects of foliar pathogen infection on bacterial communities in maize rhizosphere using high throughput sequencing. Results: Maize plants grown in non-sterilized soils displayed stronger defense against the foliar pathogen Setosphaeria turcica than those in sterilized soils. Foliar pathogen infection further triggered the shift in the structure and composition of rhizosphere bacterial communities. The pathogen-infected plants specially promoted rhizosphere colonization of several bacterial taxa. The Pseudomonas genus increased in the rhizosphere after pathogen infection. Other bacterial genera such as Chitinophaga and Flavobacterium were also greatly enriched in the rhizosphere of pathogen-infected plants. Furthermore, the enriched bacterial species were isolated and were shown to interact synergistically to promote biofilm formation. Although both the Chitinophaga and Flavobacterium species did not induce plant defense, the Pseudomonas species markedly increased the resistance of plants against S. turcica. Furthermore, the consortium consisting of the Pseudomonas, Chitinophaga and Flavobacterium species (CONpcf) conferred long-acting disease resistance of maize plants as compared to the individual Pseudomonas species. Furthermore, the inoculation with the CONpcf significantly induced a marked increase in the levels of DIMBOA in maize leaves, indicating that the consortium-induced increases of DIMBOA levels partially contributed to enhancing disease resistance of plants. Conclusions: Foliar infection of maize plants by S. turcica specifically recruited a group of beneficial rhizosphere bacteria, which conferred enhanced plant defense against pathogen infection. This study provided important evidence that above-ground pathogen infection participated in the mediation of below-ground microbiome for regulating plant defense systems.
Methylation alterations and advance of treatment in lymphoma
Authors: Liu Meng-Ke , Sun Xiao-Jian , Gao Xiao-Dong , Qian Ying , Wang Li , Zhao Wei-Li
Published: September 2021

Lymphoma is a common and aggressive form of hematopoietic malignancies with diverse clinical and pathological features due to its heterogeneity. Although the current immunochemotherapeutic regimens improve clinical outcomes, many patients still display poor prognosis and frequent relapse. Epigenetic alterations contribute to the progression of lymphoma. DNA methylation and histone methylation are the most common epigenetic alterations and regulate the gene expression involved in lymphoma pathogenesis, including silencing of tumor suppressor genes or activation of proto-oncogenes. Dysregulation or mutation of genes related to DNA methylation, including DNMTs, TET2, IDH2, and genes related to histone methylation, including EZH2, KMT2D has been observed. Most of these alterations are associated with inferior outcomes of patients with diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), peripheral T-cell lymphoma (PTCL), and other subtypes of lymphoma. To overcome the pathogenetic consequence induced by aberrant DNA methylation and histone methylation, novel targeted drugs including azacitidine and decitabine have been gradually applied in practice to enhance the efficacy of current therapy and improve the prognosis of lymphoma patients. Investigating and targeting epigenetic mechanisms in lymphoma could be a key point of future research. Therefore, we mainly summarize the methylation alterations in lymphoma and their respective targeted therapies in this review.
Neurodegeneration, memory loss, and dementia: the impact of biological clocks and circadian rhythm
Authors: Maiese Kenneth
Published: September 2021

Introduction: Dementia and cognitive loss impact a significant proportion of the global population and present almost insurmountable challenges for treatment since they stem from multifactorial etiologies. Innovative avenues for treatment are highly warranted. Methods and results: Novel work with biological clock genes that oversee circadian rhythm may meet this critical need by focusing upon the pathways of the mechanistic target of rapamycin (mTOR), the silent mating type information regulation 2 homolog 1 (Saccharomyces cerevisiae) (SIRT1), mammalian forkhead transcription factors (FoxOs), the growth factor erythropoietin (EPO), and the wingless Wnt pathway. These pathways are complex in nature, intimately associated with autophagy that can maintain circadian rhythm, and have an intricate relationship that can lead to beneficial outcomes that may offer neuroprotection, metabolic homeostasis, and prevention of cognitive loss. However, biological clocks and alterations in circadian rhythm also have the potential to lead to devastating effects involving tumorigenesis in conjunction with pathways involving Wnt that oversee angiogenesis and stem cell proliferation. Conclusions: Current work with biological clocks and circadian rhythm pathways provide exciting possibilities for the treating dementia and cognitive loss, but also provide powerful arguments to further comprehend the intimate and complex relationship among these pathways to fully potentiate desired clinical outcomes.
The renin-angiotensin system in central nervous system tumors and degenerative diseases
Authors: Haron Simon , Kilmister Ethan J , Davis Paul F , Stylli Stanley S , Mantamadiotis Theo , Kaye Andrew H , Hall Sean R , Tan Swee T , Wickremesekera Agadha C
Published: September 2021

Despite their differences, central nervous system (CNS) tumors and degenerative diseases share important molecular mechanisms underlying their pathologies, due to their common anatomy. Here we review the role of the renin-angiotensin system (RAS) in CNS tumors and degenerative diseases, to highlight common molecular features and examine the potential merits in repurposing drugs that inhibit the RAS, its bypass loops, and converging signaling pathways. The RAS consists of key components, including angiotensinogen, (pro)renin receptor (PRR), angiotensin-converting enzyme 1 (ACE1), angiotensin-converting enzyme 2 (ACE2), angiotensin I (ATI), angiotensin II (ATII), ATII receptor 1 (AT1R), ATII receptor 2 (AT2R) and the Mas receptor (MasR). The RAS is integral to systemic and cellular pathways that regulate blood pressure and body fluid equilibrium and cellular homeostasis. The main effector of the RAS is ATII which exerts its effect by binding to AT1R and AT2R through two competitive arms: an ACE1/ATII/AT1R axis, which is involved in regulating oxidative stress and neuroinflammation pathways, and an ATII/AT2R and/or ATII/ACE2/Ang(1-7)/MasR axis that potentiates neuroprotection pathways. Alterations of these axes are associated with cellular dysfunction linked to CNS diseases. The generation of ATII is also influenced by proteases that constitute bypass loops of the RAS. These bypass loops include cathepsins B, D and G and chymase and aminopeptidases. The RAS is also influenced by converging pathways such as the Wnt/β-catenin pathway which sits upstream of the RAS via PRR, a key component of the RAS. We also discuss the co-expression of components of the RAS and markers of pluripotency, such as OCT4 and SOX2, in Parkinson’s disease and glioblastoma, and their potential influences on transduction pathways involving the Wnt/β-catenin, MAPK/ERK, PI3K/AKT and vacuolar (H+) adenosine triphosphatase (V-ATPase) signaling cascades. Further research investigating modulation of the ACE1/ATII/AT1R and ACE2/Ang(1-7)/MasR axes with RAS inhibitors may lead to novel treatment of CNS tumors and degenerative diseases. The aim of this review article is to discuss and highlight experimental and epidemiological evidence for the role of the RAS, its bypass loops and convergent signaling pathways in the pathogenesis of CNS tumors and degenerative diseases, to direct research that may lead to the development of novel therapy.
An overview of chia seed (Salvia hispanica L.) bioactive peptides’ derivation and utilization as an emerging nutraceutical food
Authors: Rabail Roshina , Khan Moazzam Rafiq , Mehwish Hafiza Mahreen , Rajoka Muhammad Shahid Riaz , Lorenzo Jose Manuel , Kieliszek Marek , Khalid Abdur Rauf , Shabbir Muhammad Asim , Aadil Rana Muhammad
Published: September 2021

Chia (S. hispanica L.) is an annual herbaceous plant that has gained popularity for its seeds of high-quality vegetative proteins, richest contents of omega-3 polyunsaturated fatty acids (Ω-3 PUFA), soluble dietary fiber, and great gelling ability, as well as its high contents of bioactive peptides of antioxidative and nutraceutical potential for many other clinical biomarkers. Such health protective bioactive peptides should be utilized for supplementation in the food and nutrition industries. This review was therefore designed to align the researches done on chia bioactive peptide’s derivation, processing, consumption and to identify their antioxidative and nutraceutical potential for various disease biomarkers. The evidence gathered is fairly compelling for the health-promising nutraceutical and clinical potential of chia seed bioactive peptides as antioxidants, dipeptidyl peptidase-IV inhibitors (DPP4), angiotensin-converting enzyme (ACE) inhibitors, and anti-inflammatory drugs. Their assimilation into everyday diets has the potential to open new doors in health departments and food sectors.
Kapitał ludzki sektora MŚP w procesie aktywizacji wiejskiej przestrzeni gospodarczej
Authors: Fedan Roman , Kłak Dariusz
Published: September 2021

W niniejszej publikacji uwagę skoncentrowano na sektorze MŚP, który dzięki skupionemu w nim kapitałowi ludzkiemu kreuje wzrost gospodarczy oraz standard życia mieszkańców, szczególnie w rejonach peryferyjnych. Prócz uwarunkowań funkcjonowania małych i średnich przedsiębiorstw oraz roli władz samorządowych w przekształcaniu wiejskiej przestrzeni społeczno-gospodarczej, przedstawiono pojmowanie istoty przedsiębiorczości i sposoby kategoryzowania przedsiębiorstw w oparciu o uregulowania prawne, scharakteryzowano również zróżnicowane modele zachowań przedsiębiorstw w odniesieniu do otoczenia. Ponadto, w oparciu o analizę danych źródłowych obejmujących okres czteroletni, ukazano zmienność liczebną podmiotów gospodarczych w powiecie jarosławskim, uwzględniając układ dynamiczny oraz strukturę własnościową i organizacyjno-prawną badanych przedsiębiorstw.
RODENT: a flexible TOPSIS based routing protocol for multi-technology devices in wireless sensor networks
Authors: Nathalie Mitton  , Brandon Foubert
Published: September 2021

Wireless Sensor Networks (WSN) are efficient tools for many use cases, such as environmental monitoring. However WSN deployment is sometimes limited by the characteristics of the Radio Access Technologies (RATs) they use. To overcome some of these limitations, we propose to leverage the use of a Multiple Technologies Network (MTN). What we refer to as MTN is a network composed of nodes which are able to use several RAT and communicating wirelessly through multi-hop paths. The management of the RAT and routes must be handled by the nodes themselves, in a local and distributed way, with a

suitable communication protocol stack. Nodes may reach multiple neighbors over multiple RAT. Therefore, each stack's layer has to take the technologies' heterogeneity of the devices into account. In this article, we introduce our custom Routing Over Different Existing Network Technologies protocol (RODENT), designed for MTN. It enables dynamic (re)selection of the best route and RAT based on the data type and requirements that may evolve over time, potentially mixing each technology over a single path. RODENT relies on a multi-criteria route selection performed with a custom lightweight TOPSIS method. To assess

RODENT's performances, we implemented a functional prototype on real WSN hardware, Pycom FiPy devices. Unlike related prototypes, ours has the advantage not to rely on specific infrastructure on the operator's side. Results show that RODENT enables energy savings, an increased coverage as well as multiple data requirements support.
6G vision: An ultra-flexible perspective
Authors: Huseyin Arslan  , Seda Dogan Tusha  , Ahmet Yazar
Published: September 2021

The upcoming sixth generation (6G) communications systems are expected to support an unprecedented variety of applications, pervading every aspect of human life. It is clearly not possible to fulfill the service requirements without actualizing a plethora of flexible options pertaining to the key enabler technologies themselves. At that point, this work presents an overview of the potential 6G key enablers from the flexibility perspective, categorizes them, and provides a general framework to incorporate them in the future networks. Furthermore, the role of artificial intelligence and integrated sensing

and communications as key enablers of the presented framework is also discussed.
The Internet of MetaMaterial Things and their software enablers
Authors: Ageliki Tsioliaridou  , Alexandros Pitilakis  , Georgios G. Pyrialakos  , Christos Liaskos
Published: September 2021

A new paradigm called the Internet of MetaMaterial Things (IoMMT) is introduced in this paper where artificial materials with real-time tunable physical properties can be interconnected to form a network to realize communication through software-controlled electromagnetic, acoustic, and mechanical energy waves. The IoMMT will significantly enrich the Internet of Things ecosystem by connecting anything at any place by optimizing the physical energy propagation between the metamaterial devices during their lifetime, via "eco-firmware" updates. First, the means for abstracting the complex physics behind these materials are explored, showing their integration into the IoT world. Subsequently, two novel software categories for the material things are proposed, namely the metamaterial Application Programming Interface and Metamaterial Middleware, which will be in charge of the application and physical domains, respectively. Regarding the API, the paper provides the data model and workflows for obtaining and setting the physical properties of a material via callbacks. The Metamaterial Middleware is tasked with matching these callbacks to the corresponding material-altering actuations through embedded elements. Furthermore, a full stack implementation of the software for the electromagnetic metamaterial case is presented and evaluated, incorporating all the aforementioned aspects. Finally, interesting extensions and envisioned use cases of the IoMMT concept are discussed.
Controller placement optimization for Software Defined Wide Area Networks (SDWAN)
Authors: Albert Lysko  , Joyce Mwangama  , Lusani Mamushiane
Published: September 2021

Software Defined Networking (SDN) has emerged as a promising solution to revolutionize network deployment, operations and economic growth. This paradigm aims to address management and configuration complexities in legacy networks so as to reduce the total cost associated with deploying and running telecommunication infrastructures. At the heart of SDN is a controller which oversees orchestration of resources. An important problem that must be addressed during the initial design of an SDN-based network deployment is to find the optimal number of controllers and their locations, to achieve desired operational efficiency. This problem constitutes competing objectives such as latency, load balancing, and reliability. We apply Silhouette Analysis, Gap Statistics and the Partition Around Medoids (PAM) algorithms and, unlike previous work, we add a new method for solving the controller placement problem using an emulation orchestration platform. Our approach aims to optimize controller-to-node latency, alleviate control-plane signalling overhead and ensure control-plane resiliency. Our results for South African national research network (SANReN) reveal that deploying two controllers yields the lowest latency, reduces control-plane signalling overhead and guarantees control-plane resiliency. Our approach can be used by network operators as a guideline to start integrating SDN or plan a new SDN deployment, by helping them make quick automatic decisions regarding optimal controller placement.
Backscatter communications with passive receivers: from fundamentals to applications
Authors: Milutin Stanacevic  , Akshay Athalye  , Zygmunt J. Haas  , Samir R. Das  , Petar M. Djuric
Published: September 2021

The principle of backscattering has the potential to enable a full realization of the Internet of Things. This paradigm subsumes massively deployed things that have the capability to communicate directly with each other. Based on the types of excitation and receivers, we discriminate four types of backscattering systems: (i) Dedicated Exciter Active Receiver systems, (ii) Ambient Exciter Active Receiver systems, (iii) Dedicated Exciter Passive Receiver systems, and (iv) Ambient Exciter Passive Receiver systems. In this paper, we present an overview of bacskscattering systems with passive receivers which form the foundation for Backscattering Tag-to-Tag Networks (BTTNs). This is a technology that allows tiny batteryless RF tags attached to various objects to communicate directly with each other and to perform RF-based sensing of the communication link. We present an overview of recent innovations in hardware architectures for backscatter modulation, passive demodulation, and energy harvesting that overcome design challenges for passive tag-to-tag communication. We further describe the challenges in scaling up the architecture from a single link to a distributed network. We provide some examples of application scenarios enabled by BTTNs involving object-to-object communication and inter-object or human-object dynamic interactions. Finally, we discuss key challenges in present-day BTTN technology and future research directions.
Investigation of Burnout Levels of Physical Education and Sports Teachers during Covid-19 Period
Authors: Karakoç Berna , Karakoç Önder , Aktaş Özgür , Arslan Murat
Published: September 2021

Due to the COVID-19 pandemic, it was decided to conduct educational activities online and the burnout status of teachers who suddenly switched to distance education became a matter of curiosity. This study was carried out to examine the burnout levels of physical education and sports teachers during the Covid-19 period and to examine possible changes that may occur after this process by getting information about how they will approach their profession. profession and students. In this context, the research group consists of 210 physical education and sports teachers, 142 men and 68 women. These teachers took a break from face-to-face education due to the pandemic and continued their lessons with online education. The Maslach Burnout Inventory and 3 semi-structured questions were used to find out the emotional states of physical education and sports teachers and how they approached students during and after the pandemic. IBM SPSS 22 statistical program was used in the analysis of the data obtained from the scale. Analysis of normality showed that the data were normally distributed. Parametric test independent samples t-test was used to compare paired groups, one-way ANOVA was used to compare more than two groups and the level of significance was accepted as (p)<.05. In addition, the content analysis method was used in the analysis of the data obtained from the semi-structured interview form. The results showed that physical education and sports teachers participating in the study experienced moderate burnout. It was determined that the most negatively affected aspect of teachers was emotional exhaustion during the Covid-19 pandemic. There was no significant difference between the burnout levels of physical education and sports teachers according to the variables of gender, age, professional seniority, the type of sports they do. Physical education and sports teachers stated that they missed their students and they wanted face-to-face education to start at school, while more than half of the teachers stated that their attitudes to students will change after the pandemic.
Peran Bimbingan Keagamaan dalam Rehabilitasi Pecandu Narkoba
Authors: Ulfa Lutfia , Noor Justiatini Witrin
Published: September 2021

Permasalahan narkotika telah membuat negara di dunia merasa resah dan khawatir. Proses rehabilitasi membutuhkan waktu lama, karena kecanduan narkoba sering disertai relapse. Sehingga, pecandu mengalami kesulitan dalam mengontrol perilakunya. Teori yang digunakan dalam penelitian ini adalah teori Rational Emotive Behavior Therapy dari Albert Ellis. Teori ini sesuai dengan tujuan dari adanya pelaksanaan bimbingan keagamaan dalam rehabilitasi yaitu bagaimana caranya agar dapat mengubah mindset klien, sehingga klien dapat berpikir dan berperilaku rasional. Pendekatan dalam penelitian ini yaitu deskriptif kualitatif, dikarenakan masalah yang diteliti perlu dijelaskan secara sistematis dan faktual dengan menggambarkan keadaan tempat penelitian. Simpulan dari penelitian ini adalah bimbingan keagamaan perlu dirancang, diorganisasi, dilaksanakan, diawasi dan dievaluasi dengan baik; dalam proses rehabilitasi dibutuhkan kerjasama dan dukungan penuh dari semua faktor; hasil dari bimbingan keagamaan adalah: mendapatkan ketenangan yang hakiki; adanya perubahan mindset; dan adanya perubahan perilaku
Thoughts on China’s Rural Ecological Security Construction from the Perspective of Overall National Security Concept
Authors:   School of Economics Management and Law, University of South China, Yang Jianlan , Guo Miao ,   School of Economics Management and Law, University of South China
Published: September 2021

As a national security thought in the new era, the overall national security concept contains rich security governance theory and practical experience, which provides a scientific guide and program for the development of various security work in China. Rural ecological security, as an organic component of overall national security, interpenetrates and interacts with other areas of security, and counteracts the realization of overall national security. Based on the overall national security concept, the rural ecological security construction should adhere to the bottom line thinking, people-oriented, innovation-oriented and rule of law, and conceive an optimized path in the aspects of pre-prevention, public demand, talent integration, collaborative governance, technical means and legal system construction, which is of great significance to national development and people’s lives.
The Characters of Chinese Culture behind the Relationship between Mother-in-Law and Daughter-in-Law in China
Authors:   School of Foreign Language, Nanjing Normal University, Nanjing 210023, China, Du Yichao
Published: September 2021

The Article focus on the relationship between mother-in-law and daughter-in-law in China, analyzing the cultural reasons behind it. It’s affected by two main factors – the tradition Filial Piety and the conflict between traditional views and the new culture.
Generalisations of SDM Methods in fpfs-Matrices Space to Render Them Operable in ifpifs-Matrices Space and Their Application to Performance Ranking of the Noise-Removal Filters
Authors: ARSLAN Burak , AYDIN Tuğçe , MEMİŞ Samet , ENGİNOĞLU Serdar
Published: September 2021

Recently, the concept of intuitionistic fuzzy parameterized intuitionistic fuzzy soft matrices (ifpifs-matrices) has allowed to mathematically model some problems in which the parameters and alternatives exhibit intuitionistic fuzzy uncertainties. To this end, the present study aims to generalise 24 soft decision-making (SDM) methods operating in the fuzzy parameterized fuzzy soft matrices space with a single fpfs-matrix to the ifpifs-matrices spaces. Afterwards, we propose five test scenarios to analyse whether the SDM methods constructed by ifpifs-matrices consistently work. Moreover, we make performance comparisons of the generalised SDM methods successful in the five test scenarios by applying them to the performance-based value assignment (PVA) problem of the well-known noise-removal filters. Finally, we discuss the need for further research.
Community first responders: A missing key to reducing the impact of injury and illness in low- and middle-income countries in the Western Pacific?
Authors: Hodgetts Andrew , Massey Peter , Redman-MacLaren Michelle , Bainbridge Roxanne
Published: September 2021

This perspective article discusses the potential role community first responders could play in reducing injury and illness in low- and middle-income countries in the Western Pacific. Community first responders are reportedly making a difference in low- and middle-income countries in Asia and Africa in reducing injury and illness, and in disease surveillance and reporting. Efforts must be made to explore the appropriate and effective introduction of locally tailored community first responder programs in the Western Pacific.
Screening of hospital admissions for COVID-19 in Brunei Darussalam
Authors: Choo Sanny Zi Lung , Shafri Hazirah , Johan Fatimah Al-Zahara , Basir Norwani , Chong Pui Lin , Abdullah Muhammad Syafiq , Asli Rosmonaliza , Tan Jackson , Thottacherry Dilip Joseph , Ahmad Muhammad Ady Adillah , Chong Vui Heng
Published: September 2021

From late December 2019, an outbreak of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) occurred in Wuhan, China and has spread globally resulting in a pandemic. Brunei Darussalam reported its first case of COVID-19 on 9 March 2020. Several measures were implemented to prevent a national outbreak. We report our experience with surveillance of patients requiring admission in all government hospitals. We detected one positive case, and through contact tracing two further cases were detected. Therefore, without this screening programme, these cases would likely have been missed, leading to further nosocomial and community spread.
The first community outbreak of COVID-19 in Viet Nam: description and lessons learned
Authors: Tran Duong Nhu , Le Quynh Mai Thi , Nguyen Hien Tran , Ngu Nghia Duy , Nguyen Khoa Trong , Nguyen Tuan Hai , Tran Tu Anh , Ngo Tu Huy , Hoang Mai Phuong Vu , Dang Anh Duc
Published: September 2021

Objective: At the time of this study, the prevention of novel coronavirus disease 2019 (COVID-19) relied solely on nonpharmaceutical interventions. Implementation of these interventions is not always optimal and, consequently, several cases were imported into non-epidemic areas and led to large community outbreaks. This report describes the characteristics of the first community outbreak of COVID-19 in Viet Nam and the intensive preventive measures taken in response. Methods: Cases were detected and tested for SARS-CoV-2 by real-time reverse transcriptase polymerase chain reaction. Contact tracing and active surveillance were conducted to identify suspected cases and individuals at risk. Clinical symptoms were recorded using a standardized questionnaire. Results: In Vinh Phuc province from 20 January to 3 March 2020, there were 11 confirmed cases among 158 suspected cases and 663 contacts. Nine of the confirmed cases (81.8%) had mild symptoms at the time of detection and two (18.2%) were asymptomatic; none required admission to an intensive care unit. Five prevention and control measures were implemented, including quarantining a community of 10 645 individuals for 20 days. The outbreak was successfully contained as of 13 February 2020. Discussion: In the absence of specific interventions, the intensive use of combined preventive measures can mitigate the spread of COVID-19. The lessons learned may be useful for other communities.
Use of movement restrictions during an outbreak of COVID-19 in Selangor, Malaysia
Authors: Suleiman Anita , Ngadiman Shaari , Ramly Mazliza , Yusoff Ahmad Faudzi , Yusof Mohamed Paid
Published: September 2021

Objective: Various public health and social measures have been used during the COVID-19 outbreak, including lockdowns, contact-tracing, isolation and quarantine. The objective of this manuscript is to describe outbreaks of COVID-19 in Selangor, Malaysia, the public health strategies used and the observed impact of the measures on the epidemic curve. Methods: Information on all confirmed COVID-19 cases in Selangor between 25 January and 28 April 2020 was obtained. Clusters were identified, and cases were disaggregated into linked, unlinked and imported cases. Epidemic curves were constructed, and the timing of movement control orders was compared with the numbers of cases reported. Results: During the study period, 1395 confirmed COVID-19 cases were reported to the Selangor Health Department, of which 15.8% were imported, 79.5% were linked and 4.7% were unlinked cases. For two main clusters, the number of cases decreased after control measures were instituted, by contact-tracing followed by isolation and home quarantine for the first cluster (n = 126), and with the addition of the movement control order for the second, much larger cluster (n = 559). Discussion: The findings suggest that appropriate, timely public health interventions and movement control measures have a synergistic effect on controlling COVID-19 outbreaks.
Inteligencia Emocional y Hábitos de Estudio en Estudiantes de una Institución Publica
Authors: Garay Zorrilla Yesica Elizabeth , Nuñez Guillen Leyla Paola
Published: September 2021

La investigación tuvo un enfoque cuantitativo, descriptiva de diseño no experimental de nivel correlacional, transaccional. Los instrumentos aplicados fueron el test conociendo mis emociones y el inventario de hábitos de estudio CASM, con validez de juicio de expertos y confiabilidad por alfa de Cronbach para inteligencia emocional 0,8,94 y para los hábitos de estudio ,829, la población fue de 75 estudiantes de 3º de secundaria. Los resultados de r Spearman obtuvo un p-valor de 0,012 con lo que se afirma que la inteligencia emocional tiene una correlación significativa con los hábitos de estudio. El coeficiente de correlación de Spearman es =,290* lo indica que la correlación es positiva bajo. lo que nos permite afirmar que mayor inteligencia emocional hay un mayor nivel de habito de estudio.
La importancia de la comunicación y liderazgo: herramientas para métodos efectivos de formación y organización educativa
Authors: Reyes Jiménez Celestino
Published: September 2021

La intención de este artículo, es explicar los conceptos de comunicación y liderazgo como pilares del método formativo para las organizaciones educativas. La importancia de la comunicación asertiva es un reto constante para que los equipos y grupos sean capaces de una interacción continua y efectiva, siendo parte también de los pilares que conforman al liderazgo. Estos juegan un papel crucial en la gestión como un rol fundamental para alcanzar altos estándares de calidad en el servicio y con ello una mejor formación del ser humano como un individuo pleno consigo mismo y con su entorno hacia el bien común. El objetivo es mostrar de una manera clara la correlación de estas 2 herramientas y su impacto en la mejora educativa al ser variables que inciden en el desempeño de este sistema, al ser esenciales para que los directivos diseñen y desarrollen técnicas de mejora continua y de una cultura de innovación y aprendizaje. Una educación, por y para el liderazgo, utilizando como base la comunicación efectiva y concisa, constituye un factor determinante para el perfeccionamiento de la calidad educativa que incide en la sociedad y que busca ante todo el desarrollo integral de los individuos.
A Decision Support System for Placing Shared E-Scooters: A Case Study for Istanbul
Authors: MORALIOĞLU Begüm , CENANİ Şehnaz , ÇAĞDAŞ Gülen
Published: September 2021

A smart and sustainable city should be an innovative city that uses information and communication technologies to improve the quality of life via its operations. They need to be planned, managed, and regulated by open data collected through different data sources to provide efficient services. Transportation services can be accepted as one of the essential services of a city. In smart cities, intelligent transportation systems help to solve problems such as traffic congestion or the amount of fuel spent in traffic by providing communication between vehicles and devices that build the whole transportation network. In order to achieve the success of intelligent transportation systems, transportation methods should be planned dynamically according to the collected data and the requirements of the city's transportation network. E-scooters are also a part of the transportation system, and since 2017, shared e-scooter systems have been used as a transportation alternative in some cities. However, e-scooters are placed in random locations in cities without relying on a precise algorithm. Thus, users in some locations cannot benefit from the e-scooter sharing system efficiently due to the lack of e-scooter in neighborhoods. In this study, a decision support system for e-scooter sharing systems is suggested, which helps to place e-scooters dynamically in areas that are needed in the city. This system is intended to offer select options by combining the traffic density information of the regions and alternative region data provided by the multi-criteria analysis made using the Analytical Hierarchy Method (AHP) with real-time social media data.
Origami ve Hücresel Özdevinim Entegrasyonu ile Kabuk Tasarımı
Authors: ÖZBEK Hatice Melike
Published: September 2021

Bu çalışma kapsamında origami ve hücresel özdevinimin entegre bir şekilde kullanarak tasarımda kullanılmasının uygunluğu araştırılmıştır. Origaminin doğasından gelen hareketli olma ve değişip dönüşebilme durumu; yapısal anlamda ilham verici bir durumdur. Bu konu ele alınırken belirme kavramıyla entegre bir sistem üretmek, belirlenen kurallarla ve sistemin içindeki parçaların kendileri arasındaki etkileşimleriyle beliren bir sistem oluşturmak tasarımı güçlendirecektir. Çalışma kapsamında origaminin modüler kullanımı ele alınmış ve modüllerin bir araya gelişinde de hücresel özdevinim kullanılmıştır. Hücresel özdevinim ile sayısız varyasyonlar üretilecek olup bütün bu örneklerin de kendi içindeki hareket durumuyla farklı formlara girebilecek olması; tasarımcıya ve kullanıcıya farklı mekanlar ve senaryolar için sayısız alternatif üretecektir. Bu kapsamda origami, öncelikle manuel denemelerle keşfedilerek kullanılacak sisteme karar verilmiş ve devamında dijital modelleme ile üretimler desteklenmiştir. Manuel ve dijital üretim yöntemleri birbirlerini desteklemiş olup; sürç içinde geri bildirimlerle modelin ve tasarımın gelişimi sağlanmıştır. Rhino-Grasshopper ile oluşturulan modellerde origami simülasyonu oluşturabilmek için “Crane” eklentisi kullanılmıştır. Dijital üretimlerde origami hareketinin simüle edilmesi; manuel çalışmalarda üretilmesi zor, sayıca fazla modülden oluşan kabuk tasarımlarının gireceği formlar açısından yol gösterici olmuştur. Çalışmanın devamında tasarımın üretimine yönelik araştırmalar yapılmış olup sistem önerisi geliştirilmiştir. Son olarak bu sistemin kinetik durumu araştırılmış ve hareketi sağlayacak sistemle ilgili çalışmalar yapılmıştır. Origaminin uygun malzeme ve sistem seçimi ile tasarımcıyı pek çok alternatif tasarımlara götürdüğü görülmüştür. Origaminin sahip olduğu kinetik sistem ve bunun hücresel özdevinimle desteklenmesiyle; belirmeyi her açıdan destekleyen kullanıcı etkileşimli ve farklı senaryolara adapte olabilen bir kabuk tasarımına ulaşılmıştır.
Emergence and complexity in agent-based modeling: Review of state-of-the-art research
Authors: CENANİ Şehnaz
Published: September 2021

Agent-based systems are an important application area of artificial intelligence and are used in decision support systems. Rather than being a problem-solving tool, agent-based system is a tool for developing and testing alternative solutions according to various scenarios. In this context, agent-based modeling is a very effective method to support decision makers in emergency situations to evaluate different risk scenarios and then make decisions quickly and effectively. Moreover, agent-based modeling is a very useful method to support decision makers in situations of high complexity and uncertainty. The aim of this study is to review state-of-the-art research and give researchers insights into how to use agent-based modeling while developing decision support systems. This paper introduces current studies performed with several agent-based modeling toolkits and software environments such as NetLogo, AnyLogic, MATSim and Repast. In this paper, after giving a brief definition of an agent-based system and explaining the importance of concepts such as emergence and complexity in the field of agent-based modeling, it is explained who uses the agent-based models for what purpose, when, where, why and how to use agent-based modeling through selected examples from state-of-the-art studies carried out in different research fields. Furthermore, what current studies teach us and how future studies can benefit from agent-based models are briefly discussed.
Influence of Information Security Culture on the Information Security Governance Capabilities (Case Study: PT XYZ)
Authors: Suwandi Kevin , Setiawan Johan
Published: September 2021

Objective – To analyze the relationship between a company’s information security approach/culture with its information security governance capabilities based on COBIT 5 framework and provide recommendations that can be used to improve the company's information security capabilities per COBIT 5 standard.

Methodology – The research uses qualitative and quantitative methods by conducting interviews and distributing questionnaires to 3 members of the IT Department at PT XYZ.

Findings – The research found that the measured COBIT 5 processes (APO13 and DSS05) failed to reach the expected target (level 4), with each DSS05 and APO13 can only reach level 1 and 2 respectively. In addition, several flaws were also found in the company’s information security culturethat may have contributed directly or indirectly to the current state of the company’s information security capabilities.

Novelty – In this study, the researchers expand the previous study on information security culture conducted in 2010 by performing a security audit on a company's IT department to analyze the connection between corporate culture, especially information security culture and the capability level of information security governance. The company thus can make improvements or corrections to its information security approach/culture based on the recommendations provided with COBIT 5 framework.

Keywords: Capability Level; COBIT; Governance; Information Security Culture.