bluuebunny/crossref_metadata_2025 huggingface dataset:
A platinum porphyrin modified TiO2 electrode for photoelectrochemical hydrogen production from neutral water driven by the conduction band edge potential of TiO2
Authors: Morita Kohei , Takijiri Kohei , Sakai Ken , Ozawa Hironobu
Published: October 2017

A TiO2 electrode modified with a platinum(ii) porphyrin catalyst, prepared by using our “pyridyl anchoring technique”, catalyzes H2 production from neutral water with excellent long-term durability.
Flexible/shape-versatile, bipolar all-solid-state lithium-ion batteries prepared by multistage printing
Authors: Kim Se-Hee , Choi Keun-Ho , Cho Sung-Ju , Yoo JongTae , Lee Seong-Sun , Lee Sang-Young
Published: October 2017

The flexible/shape-versatile bipolar all-solid-state LIBs, which fabricated via solvent-drying-free, UV-curing-assisted multistage printing, are presented as an unprecedented material/process strategy to address longstanding challenges associated with inorganic-electrolyte-based bipolar LIBs.
Modulation of reactive oxygen species production, apoptosis and cell cycle in pleural exudate cells of carrageenan-induced acute inflammation in rats by rutin
Authors: Adefegha Stephen Adeniyi , Leal Daniela Bitencourt Rosa , de Oliveira Juliana Sorraila , Manzoni Alessandra Guedes , Bremm Joao Matheus
Published: October 2017

The present study seeks to investigate the effect of rutin, a flavonoid compound in rat models of acute inflammation induced by carrageenan (CAR).
Direct conversion of bio-ethanol to propylene in high yield over the composite of In2O3 and zeolite beta
Authors: Xue Fangqi , Miao Changxi , Yue Yinghong , Hua Weiming , Gao Zi
Published: October 2017

The superior propylene yield of the In2O3-beta composite (ca. 50%) for the conversion of ethanol to propylene compared to In2O3 (ca. 32%) is due to the fact that zeolite beta in the composite enhances the conversion of the intermediate of acetone to propylene via an additional pathway.
Inkjet-printed barcodes for a rapid and multiplexed paper-based assay compatible with mobile devices
Authors: Yang Mingzhu , Zhang Wei , Zheng Wenshu , Cao Fengjing , Jiang Xingyu
Published: October 2017

Various signal generation models, such as the generation of colorimetric, fluorescent, chemiluminescent, electrochemical, and electroluminescent signals, provide a possibility of qualitative and quantitative analyses based on PADs.
Customised spatiotemporal temperature gradients created by a liquid metal enabled vortex generator
Authors: Zhu Jiu Yang , Thurgood Peter , Nguyen Ngan , Ghorbani Kamran , Khoshmanesh Khashayar
Published: October 2017

The continuous electrowetting effect is utilised for producing highly reconfigurable vortices, enabling us to generate customised temperature gradients in repeated cycles.
Molecular dynamics simulations of β2-microglobulin interaction with hydrophobic surfaces
Authors: Dongmo Foumthuim Cedrix J. , Corazza Alessandra , Esposito Gennaro , Fogolari Federico
Published: October 2017

27 copies of β2-microglobulin interacting with a cubic hydrophobic box (not shown for the sake of clarity). The proteins readily adsorb and undergo partial unfolding.
Inverting the design path for self-assembled block copolymers
Authors: Gadelrab Karim R. , Hannon Adam F. , Ross Caroline A. , Alexander-Katz Alfredo
Published: October 2017

Recent success of inverse design methodologies in the realm of self-assembled materials has allowed us to envision an inverse path of discovery where we go from a desired target function to building blocks.
Selenium-mediated arsenic excretion in mammals: a synchrotron-based study of whole-body distribution and tissue-specific chemistry
Authors: Ponomarenko Olena , La Porte Paul F. , Singh Satya P. , Langan George , Fleming David E. B. , Spallholz Julian E. , Alauddin Mohammad , Ahsan Habibul , Ahmed Selim , Gailer Jürgen , George Graham N. , Pickering Ingrid J.
Published: October 2017

Organ and tissue-level studies demonstrate selenium binding to arsenic in vivo in mammals, facilitating excretion.
Preparation of metalated azine complexes of iridium(iii)
Authors: Albertin Gabriele , Antoniutti Stefano , Bortoluzzi Marco , Castro Jesús , Sibilla Francesca , Trave Enrico
Published: October 2017

The preparation of half-sandwich κ1-aldazine and κ1-ketazine complexes of iridium and their metalation reaction affording chelate κ2-azine derivatives are described. The photoluminescence properties of the chelate complexes are also described.
N-Methyl-N,N,N-trioctylammonium chloride as a novel and green corrosion inhibitor for mild steel in an acid chloride medium: electrochemical, DFT and MD studies
Authors: Haque Jiyaul , Srivastava V. , Verma Chandrabhan , Lgaz H. , Salghi R. , Quraishi M. A.
Published: October 2017

In the present work, N-methyl-N,N,N-trioctylammonium chloride (Aliquat 336) has been evaluated as a green and novel corrosion inhibitor for mild steel in a 1 M HCl solution.
Improved rate capability and cycling stability of bicontinuous hierarchical mesoporous LiFePO4/C microbelts for lithium-ion batteries
Authors: Zhang Yue , Huang Yudai , Tang Yakun , Zhao Hongyang , Cai Yanjun , Wang Xingchao , Guo Yong , Jia Dianzeng , Zong Jun
Published: October 2017

Bicontinuous hierarchical mesoporous LiFePO4/C microbelts have been synthesized using a simple dual-solvent electrospinning method for the first time. The sample exhibits a high reversible capacity (153 mA h g−1at 0.5C), and an excellent high rate cycling performance.
Ni@M (M = Pt, Pd and Ru) core@shell nanoparticles on a Vulcan XC-72R support with superior catalytic activity toward borohydride oxidation: electrochemical and fuel cell studies
Authors: Hosseini M. G. , Mahmoodi R.
Published: October 2017

Ni@Pd/C has excellent catalytic activity and power density for borohydride oxidation in comparison with Ni@Pt/C and Ni@Ru/C.
Click-on fluorescent triazolyl coumarin peptidomimetics as inhibitors of human breast cancer cell line MCF-7
Authors: Thasnim P. , Bahulayan D.
Published: October 2017

A fluorogenic click reaction which enables the formation of fluorescent and bioactive triazolylcoumarinsviaa photoinduced electron transfer process is described.
PdCuCeO–TPAB: a new catalytic system for quasi-heterogeneous Suzuki–Miyaura cross-coupling reactions under ligand-free conditions in water
Authors: Mpungose Philani P. , Sehloko Neo I. , Maguire Glenn E. M. , Friedrich Holger B.
Published: October 2017

PdCuCeO was applied for Suzuki–Miyaura coupling in pure water. The catalyst was highly active (TOF > 3000 h−1) and could be reused.
Simultaneous phase and size manipulation in NaYF4:Er3+/Yb3+ upconverting nanoparticles for a non-invasion optical thermometer
Authors: Du Peng , Deng An Meng , Luo Laihui , Yu Jae Su
Published: October 2017

A series of Er3+/Yb3+-codoped NaYF4 upconverting nanoparticles were synthesized via a hydrothermal method.
Substituent swap affects the crystal structure and properties of N-benzyl-4-amino-1,2,4-triazole related organic salts
Authors: Wang Jing-Wen , Li Yao-Jia , Chen Chen , Luo Yang-Hui , Sun Bai-Wang
Published: October 2017

Different inorganic anions bridging the ligands to form structurally different 3-D frameworks, which vary in π⋯π stacking motifs, solubilities, and thermogravimetric and emission properties, are reported.
Facile fabrication of graphene-encapsulated Mn3O4 octahedra cross-linked with a silver network as a high-capacity anode material for lithium ion batteries
Authors: Liu Binbin , Qi Lei , Ye Jiajia , Wang Jieqiang , Xu Caixia
Published: October 2017

Mn3O4 octahedra with a bimodal conductive network of nanoporous Ag and graphene nanosheets are simply prepared for better Li storage as an advanced anode material.
The anion impact on the self-assembly of naphthalene diimide diimidazolium salts
Authors: Billeci Floriana , D'Anna Francesca , Chiarotto Isabella , Feroci Marta , Marullo Salvatore
Published: October 2017

Self-assembly behavior of naphthalene diimide diimidazolium salts was analyzed as a function of their anions. Changes in the anion nature significantly impact the properties of aggregates.
Carbosilane dendrons with fatty acids at the core as a new potential microbicide against HSV-2/HIV-1 co-infection
Authors: Guerrero-Beltrán C. , Ceña-Diez R. , Sepúlveda-Crespo D. , De la Mata J. , Gómez R. , Leal M. , Muñoz-Fernández M. A. , Jiménez J. L.
Published: October 2017

The development of a HSV-2/HIV-1 co-infectionin vitromodel (a): dendrons prevented HIV-1 infection even if mucosal disruptions occur as a consequence of HSV-2 infection (b).
Blocking probe as a potential tool for detection of single nucleotide DNA mutations: design and performance
Authors: Aboudzadeh M. Ali. , Sanromán-Iglesias M. , Lawrie C. H. , Grzelczak M. , Liz-Marzán L. M. , Schäfer T.
Published: October 2017

Blocking probe efficiency is very dependent on the binding position, as the secondary structure present in the target single strand can significantly suppress it.
Ion transport in gel and gel–liquid systems for LiClO4-doped PMMA at the meso- and nanoscales
Authors: Plett Timothy , Thai Mya Le , Cai Josslyn , Vlassiouk Ivan , Penner Reginald M. , Siwy Zuzanna S.
Published: October 2017

Ionic transport in gel electrolytes at the nano- and mesoscales is explored experimentally using single pores.
An amorphous Co-carbonate-hydroxide nanowire array for efficient and durable oxygen evolution reaction in carbonate electrolytes
Authors: Xie Maowen , Yang Lin , Ji Yuyao , Wang Ziqiang , Ren Xiang , Liu Zhiang , Asiri Abdullah M. , Xiong Xiaoli , Sun Xuping
Published: October 2017

A Co-carbonate-hydroxide nanowire array on nickel foam (CoCH/NF) is durable for water oxidation electrocatalysis with superior activity to its Co(CO3)0.5(OH)·0.11H2O nanoarray precursor CoCHH/NF in 1.0 M K–Ci.
Selective recognition of quaternary ammonium ions and zwitterions by using a biomimetic bis-calix[6]arene-based receptor
Authors: Moerkerke Steven , Malytskyi Volodymyr , Marcélis Lionel , Wouters Johan , Jabin Ivan
Published: October 2017

A biomimetic bis-calix[6]arene binds cationic and zwitterionic species with a high selectivity for carbamylcholine.
Decoration of trastuzumab with short oligonucleotides: synthesis and detailed characterization
Authors: Carvalho A. M. , Manicardi A. , Montes C. Véliz , Gunnoo S. B. , Schneider R. J. , Madder A.
Published: October 2017

Trastuzumab, an antibody prescribed for the treatment of metastatic breast cancer, was covalently conjugated to oligonucleotides and characterized by high resolution MALDI-ToF MS.
Multifunctional polymers built on copper–thioether coordination
Authors: Zhang Jiuyang , Li Min , Cheng Lin , Li Tuoqi
Published: October 2017

Copper–thioether coordinated block polymers were successfully constructed to form mechanically tough materials with a color response towards hydrochloric acid and hydrogen peroxide.
An efficient approach to synthesize glycerol dendrimers via thiol–yne “click” chemistry and their application in stabilization of gold nanoparticles with X-ray attenuation properties
Authors: Li Na , Tsoi Tik-Hung , Lo Wai-Sum , Gu Yan-Juan , Wan Hoi-Ying , Wong Wing-Tak
Published: October 2017

We report an efficient synthesis of glycerol dendrimers via thiol–yne chemistry for stabilization of AuNPs with X-ray attenuation properties.
Evolution of two routes for asymmetric total synthesis of tetrahydroprotoberberine alkaloids
Authors: Yu Jingxun , Zhang Zhihong , Zhou Shiqiang , Zhang Wei , Tong Rongbiao
Published: October 2017

Two routes were developed for the catalytic asymmetric total synthesis of tetrahydroprotoberberine alkaloids.
Brain grants permission of access to Zika virus but denies entry to drugs: a molecular modeling perspective to infiltrate the boundary
Authors: Devnarain Nikita , Ramharack Pritika , Soliman Mahmoud E.
Published: October 2017

Thein silicodesign of targeted Zika virus inhibitors.
Graphene formation at 150 °C using indium as catalyst
Authors: Araby Mona Ibrahim , Rosmi Mohamad Saufi , Vishwakarma Riteshkumar , Sharma Subash , Wakamatsu Yuji , Takahashi Kazunari , Kalita Golap , Kitazawa Masashi , Tanemura Masaki
Published: October 2017

Graphene was synthesized at 150 °C. Carbon foils were irradiated with Ar+ions with a simultaneous supply of indium to synthesize conical structures with nanofibers giving new insight into the catalytic activity of indium in graphene synthesis.
An electrogenerated base for the alkaline oxidative pretreatment of lignocellulosic biomass to produce bioethanol
Authors: Liu Tongjun , Li Zhenglong
Published: October 2017

Electrogenerated base (EGB), an alternative source for alkaline pretreatment, can achieve the same performance as NaOH.
Recent advances in hybrid measurement methods based on atomic force microscopy and surface sensitive measurement techniques
Authors: Handschuh-Wang Stephan , Wang Tao , Zhou Xuechang
Published: October 2017

This review summaries the recent progress of the combination of optical and non-optical surface sensitive techniques with the atomic force microscopy.
pH-Responsive nanofiltration membranes based on porphyrin supramolecular self-assembly by layer-by-layer technique
Authors: Wu Chenglin , Zhao Lizhi , Zhang Yuzhong
Published: October 2017

A novel pH-responsive nanofiltration membrane was fabricated by means of layer-by-layer technique based on porphyrin supramolecular self-assembly.
Preparation of N, P co-doped activated carbons derived from honeycomb as an electrode material for supercapacitors
Authors: Yan Yan , Xu Mengjiao , Luo Yuqing , Ma Jingyi , Pang Huan , Xue Huaiguo
Published: October 2017

Preparation of N, P co-doped activated carbon derived from the honeycomb as an electrode material for supercapacitors.
A novel triazine-rich polymer wrapped MMT: synthesis, characterization and its application in flame-retardant poly(butylene terephthalate)
Authors: Xin Fei , Guo Chao , Chen Yu , Zhang Hailong , Qian Lijun
Published: October 2017

A novel flame retardant (PTAC–MMT) was successfully prepared by wrapping montmorillonite (MMT) with poly(2,4,6-triallyloxy-1,3,5-triazine) (TAC) via in situ polymerization, and its structure and properties were systematically characterized.
Evaluating the toxicity of silicon dioxide nanoparticles on neural stem cells using RNA-Seq
Authors: Sun Dayu , Gong Linji , Xie Jing , He Xiao , Chen Siyu , A Luodan , Li Qiyou , Gu Zhanjun , Xu Haiwei
Published: October 2017

Neural stem cells are characterized by self-renewal and multipotency, and a capacity to regenerate in response to brain injury or neurodegenerative disease.
Surface electron dynamics in hematite (α-Fe2O3): correlation between ultrafast surface electron trapping and small polaron formation
Authors: Husek Jakub , Cirri Anthony , Biswas Somnath , Baker L. Robert
Published: October 2017

Ultrafast soft X-ray reflection-absorption spectroscopy as a probe for following surface charge carrier dynamics in catalytically-relevant functional materials.
Site-isolated manganese carbonyl on bipyridine-functionalities of periodic mesoporous organosilicas: efficient CO2 photoreduction and detection of key reaction intermediates
Authors: Wang Xia , Thiel Indre , Fedorov Alexey , Copéret Christophe , Mougel Victor , Fontecave Marc
Published: October 2017

Robust heterogeneous bipyridine-based periodic mesoporous organosilica manganese catalysts are highly active for CO2 photoreduction.
Bond breakage under pressure in a metal organic framework
Authors: Su Zhi , Miao Yu-Run , Zhang Guanghui , Miller Jeffrey T. , Suslick Kenneth S.
Published: October 2017

The internal free volume of porous materials diminishes upon mechanical compression, and such volume collapse can have chemical consequences.
Fluoro-substituted cyanine for reliablein vivolabelling of amyloid-β oligomers and neuroprotection against amyloid-β induced toxicity
Authors: Li Yinhui , Xu Di , Sun Anyang , Ho See-Lok , Poon Chung-Yan , Chan Hei-Nga , Ng Olivia T. W. , Yung Ken K. L. , Yan Hui , Li Hung-Wing , Wong Man Shing
Published: October 2017

A fluoro-substituted cyanine showing reliable in vivo labelling of Aβ oligomers and potent neuroprotective effect against Aβ-induced toxicities is reported as a novel theranostic agent for the early diagnosis and therapy of Alzheimer's disease.
Supramolecular assembly affording a ratiometric two-photon fluorescent nanoprobe for quantitative detection and bioimaging
Authors: Wang Peng , Zhang Cheng , Liu Hong-Wen , Xiong Mengyi , Yin Sheng-Yan , Yang Yue , Hu Xiao-Xiao , Yin Xia , Zhang Xiao-Bing , Tan Weihong
Published: October 2017

A two photon-excited fluorescent supramolecular nanoplatform is first designed for quantitative analysis with host molecules, sensing probes and an internal reference.
Diethylenetriamine-mediated self-assembly of three-dimensional hierarchical nanoporous CoP nanoflowers/pristine graphene interconnected networks as efficient electrocatalysts toward hydrogen evolution
Authors: Fan Xiuling , Wang Xiaoyan , Yuan Weiyong , Li Chang Ming
Published: October 2017

A 3D hierarchical nanoporous CoP nanoflowers/graphene interconnected network was synthesized via DETA-mediated self-assembly, showing superior HER catalytic performance.
Isostaticity and the solidification of semiflexible polymer melts
Authors: Plaza-Rivera Christian O. , Nguyen Hong T. , Hoy Robert S.
Published: October 2017

Using molecular dynamics simulations of a tangent-soft-sphere bead-spring polymer model, we examine the degree to which semiflexible polymer melts solidify at isostaticity.
Wrinkling-to-delamination transition in thin polymer films on compliant substrates
Authors: Nolte Adam J. , Young Chung Jun , Davis Chelsea S. , Stafford Christopher M.
Published: October 2017

Compressing a thin, stiff film attached to a thick, compliant substrate can lead to a number of different modes of mechanical deformation depending upon the material properties of the system. We examine the wrinkle-to-delamination transition both analytically and experimentally.
Weak lensing magnification of SpARCS galaxy clusters
Authors: Tudorica A. , Hildebrandt H. , Tewes M. , Hoekstra H. , Morrison C. B. , Muzzin A. , Wilson G. , Yee H. K. C. , Lidman C. , Hicks A. , Nantais J. , Erben T. , van der Burg R. F. J. , Demarco R.
Published: October 2017

Context. Measuring and calibrating relations between cluster observables is critical for resource-limited studies. The mass–richness relation of clusters offers an observationally inexpensive way of estimating masses. Its calibration is essential for cluster and cosmological studies, especially for high-redshift clusters. Weak gravitational lensing magnification is a promising and complementary method to shear studies, that can be applied at higher redshifts.

Aims. We aim to employ the weak lensing magnification method to calibrate the mass–richness relation up to a redshift of 1.4. We used the Spitzer Adaptation of the Red-Sequence Cluster Survey (SpARCS) galaxy cluster candidates (0.2 < z < 1.4) and optical data from the Canada France Hawaii Telescope (CFHT) to test whether magnification can be effectively used to constrain the mass of high-redshift clusters.

Methods. Lyman-break galaxies (LBGs) selected using the u-band dropout technique and their colours were used as a background sample of sources. LBG positions were cross-correlated with the centres of the sample of SpARCS clusters to estimate the magnification signal, which was optimally-weighted using an externally-calibrated LBG luminosity function. The signal was measured for cluster sub-samples, binned in both redshift and richness.

Results. We measured the cross-correlation between the positions of galaxy cluster candidates and LBGs and detected a weak lensing magnification signal for all bins at a detection significance of 2.6–5.5σ. In particular, the significance of the measurement for clusters with z> 1.0 is 4.1σ; for the entire cluster sample we obtained an average M200 of 1.28 -0.21+0.23 × 1014 M⊙.

Conclusions. Our measurements demonstrated the feasibility of using weak lensing magnification as a viable tool for determining the average halo masses for samples of high redshift galaxy clusters. The results also established the success of using galaxy over-densities to select massive clusters at z > 1. Additional studies are necessary for further modelling of the various systematic effects we discussed.
Catalyst-Free Regioselective Nazarov Cyclization of Aryl Allenyl Ketones
Authors: Miao Maozhong , Ren Hongjun , Xu Huaping , Luo Yi , Jin Mengchao , Chen Zhengkai , Xu Jianfeng
Published: October 2017

The catalyst-free Nazarov cyclization of aryl allenyl ketones under thermal condition is developed. Various densely functionalized 2,3-dihydroindanones or indenones are readily produced in moderate to excellent yields. Significantly, this procedure features high functional group tolerance and exclusive regioselectivity. The resulting substituted 2,3-dihydroindanones can be conveniently converted into valuable conjugated benzofulvene building blocks.
Platelet CLEC-2: Roles Beyond Hemostasis
Authors: Tsukiji Nagaharu , Shirai Toshiaki , Osada Makoto , Inoue Osamu , Ozaki Yukio , Suzuki-Inoue Katsue
Published: October 2017

C-type lectin-like receptor 2 (CLEC-2) has been identified on the surface of platelets as a receptor for a platelet activating snake venom, rhodocytin/aggretin. CLEC-2 belongs to a C-type lectin superfamily and binds to a sialoglycoprotein, podoplanin, in vivo. Platelets play a crucial role in hemostasis and thrombosis, but recent studies have uncovered multiple roles of platelets beyond hemostasis in physiology and pathology. The interaction between platelet CLEC-2 and podoplanin is the key to several roles of platelets beyond hemostasis. The spatial and temporal expression patterns of podoplanin regulate vascular/lymphatic development, maintenance of vascular integrity, tissue regeneration, and some pathological processes including tumor metastasis and thromboinflammation. CLEC-2 facilitates blood/lymphatic vessel separation during embryonic development by binding to podoplanin on lymphatic endothelial cells. The leakage of platelets from hyperpermeable vessels for maintaining vascular integrity during inflammation depends on CLEC-2. During wound healing, the expression of podoplanin in keratinocytes is upregulated, which helps in the process. Podoplanin is expressed on the surface of tumor cells and facilitates hematogenous metastasis by inducing platelet aggregation through CLEC-2. During thrombotic processes, such as development of deep vein thrombosis, podoplanin is upregulated on unknown cells in the vessel wall in the area of inflammation, facilitates thrombus formation, and promotes further inflammation by binding to CLEC-2. In this article, the roles of platelets beyond hemostasis are comprehensively reviewed.
First Experiences with Incisional Negative Pressure Wound Therapy in a High-Risk Poststernotomy Patient Population treated with Pectoralis Major Muscle Flap for Deep Sternal Wound Infection
Authors: Nickl Stefanie , Steindl Johannes , Langthaler Daniel , Nierlich-Hold Alina , Pona Igor , Hitzl Wolfgang , Kocher Alfred , Happak Wolfgang , Radtke Christine , Tzou Chieh-Han
Published: October 2017

Background Radical debridement and wound closure with vascularized flaps has become a standard procedure in the treatment of deep sternal wound infections. Negative pressure incision management systems have been proven to diminish wound infections after sternotomy. In this study, the utility of Prevena Incision Management System (KCI Licensing Inc.) was evaluated in obese patients who received unilateral pectoralis major flap for the treatment of deep sternal wound infections.

Methods The outcome and wound-related complication rates of 19 obese patients (mean body mass index, 33.7) treated for deep sternal wound infection with pectoralis major muscle flap in combination with Prevena between 2011 and 2016 were compared with 28 obese patients treated with conventional wound dressing only between 2000 and 2010.

Results In patients additionally treated with Prevena, significantly fewer surgical revisions due to wound-related complications were necessary as compared with patients who received conventional wound dressing (5.3 vs. 32.1%, p = 0.034). A significantly shorter ICU length of stay (median 0 vs. 3.5 days, p < 0.001) and a trend toward shorter length of hospitalization (median 14 vs. 19.5 days after pectoralis major flap) could be observed.

Conclusion The application of Prevena significantly reduced revision surgery rates in obese patients treated with unilateral pectoralis major flap for deep sternal wound infections.
Surgical Duration Impacts Venous Thromboembolism Risk in Microsurgical Breast Reconstruction
Authors: Qiu Cecil , Jordan Sumanas , Dorfman Robert , Vu Michael , Alghoul Mohammed , Kim John
Published: October 2017

Background Increased surgical duration can impact patient outcomes and operative efficiency metrics. In particular, there are studies suggesting that increased surgical duration can increase the risk of venous thromboembolism (VTE). One of the longer duration plastic surgery procedures commonly performed is microsurgical breast reconstruction. With the widening indications for multiple and “stacked” free flaps to reconstruct breasts, we endeavored to assess (1) the relationship between duration of microsurgical breast reconstruction and VTE; and (2) determine if a threshold operative time exists that connotes VTE higher risk.

Methods Patients from the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) between 2005 and 2014 who underwent microsurgical breast reconstruction were identified by Current Procedural Terminology code. Three models of multivariate logistic regression were used to characterize the adjusted risk for VTE by operative duration, bilaterality, the length of stay, and patient demographics.

Results A total of 4,782 patients who underwent microsurgical breast reconstruction were identified. Overall VTE incidence was 1.13%. The mean operative duration was 8:31 hours:minutes (standard deviation: 2:59). Operative duration was statistically associated with VTE in continuous, quintile, and dichotomized risk models. Beyond an operative duration of 11 hours, adjusted VTE risk increases fourfold corresponding to a number needed to harm of 45.8.

Conclusions Increasing surgical duration heightens the risk of VTE in microsurgical breast reconstruction. Increasing body mass index and age enhances this VTE risk. Moreover, limiting surgical duration to 11 hours or less can decrease VTE risk by fourfold vis-à-vis baseline.

Level of Evidence Risk, II.
Case Series on Perforator Aneurysm: Endovascular Stenting—A Safe Strategy
Authors: Sahu Chandra , Ashpilaya Ashish
Published: October 2017

Perforator aneurysms are rare vascular lesions that are infrequently reported in literature, and because of difficult anatomic approach, their treatment and management pose challenges. Given the rarity of these aneurysms, the natural history and ideal approach to treatment has not been established. The authors retrospectively analyzed six patients, age ranging from 16 to 75 years with ruptured perforator aneurysm, four of posterior circulation and two of anterior circulation including clinical characteristics, imaging data, treatment regimen, and outcome. All but two patients presented with the World Federation of Neurosurgical Societies grades I to III and Fisher grade 2 or 3 subarachnoid hemorrhage, and the other two presented with intracerebral bleed in the right gangliocapsular region. Four patients were managed conservatively whereas two basilar perforator aneurysms were treated with endovascular stent. At the last follow-up, the endovascularly treated group of patients demonstrated complete thrombosis of aneurysm with preservation of perforators, and the conservatively managed group showed spontaneous occlusion in one patient, whereas three were lost to follow-up and ultimate outcome remains unknown. The authors report single-center hospital-based experience in six patients, which adds to the scarce published literature that addresses the limited understanding of the natural course and consolidating safe endovascular management of this entity.
Long-Term Survival after Salvage Surgery for Local Failure after Definitive Chemoradiation Therapy for Locally Advanced Non-small Cell Lung Cancer
Authors: Dudek Wojciech , Lettmaier Sebastian , Fietkau Rainer , Sirbu Horia , Schreiner Waldemar
Published: October 2017

Background The incidence of local failure and residual tumor after definitive chemoradiation therapy (dCRT) for locally advanced non-small-cell lung cancer remains high, irrespective of applied radiation dose (>59 Gy). So-called salvage surgery has been suggested as a feasible treatment option after failure of definitive chemoradiation for locally advanced non-small cell lung cancer (NSCLC). Experience with salvage lung surgery (SLS) is limited, and long-term survival is rarely reported. Patient selection criteria for surgical lung salvage are not defined. The aim of this study was to assess postoperative survival and perioperative morbidity/mortality to identify prognostic factors and to define patient selection criteria.

Patients and Methods Records of 13 consecutive patients with locally advanced NSCLC, who underwent SLS at a single institution between March 2011 and November 2016, were reviewed. Descriptive statistics were applied for patient characteristics and surgical and oncological outcome. Survival rates were calculated using the Kaplan–Meier method and were compared with the long-rank test.

Results All patients initially received curative-intent definitive chemoradiation with median radiation doses of 66 Gy (range 59.4–72) and concurrent platinum-based chemotherapy. Clinical tumor stage before definitive chemoradiation was IIIA in 9, IIIB in 3, IV in 1 patients. Median interval between definitive chemoradiation and salvage surgery was 6.7 months. Perioperative morbidity and 30-days-mortality was 38% and 7.7%, respectively. The median postoperative survival and estimated 5-year survival rate were 29.7 months and 46%, respectively.

Conclusion SLS in patients with locally advanced non-small cell lung surgery following dCRT is feasible, prolongs long-term survival and allows local tumor control. Selection criteria remain undefined and patients should be considered surgical candidates during multidisciplinary team conference.
Chemoradiation Therapy Followed by Surgery in the Treatment of Locoregionally Advanced Non–Small Cell Lung Cancer
Authors: Pop Daniel , Venissac Nicolas , Poudenx Michel , Otto Josiane , Castelnau Olivier , Mouroux Jérome , Cohen Charlotte
Published: October 2017

Background The aim of this study was to explore the feasibility of surgery after two induction cycles of cisplatin-docetaxel followed by concomitant 40 Gy chemoradiation in the treatment of initially unresectable stage III non–small cell lung cancer (NSCLC; TAXCIS protocol), and to evaluate overall survival (OS) and recurrence-free survival (RFS) and recurrence risk factors over a larger cohort of patients with a subgroup analysis of patients treated by pneumonectomy.

Methods Between 2004 and 2014, a total of 37 patients were treated. Only patients responding to induction treatment were included.

Results We operated on 32 stage IIIA and 5 stage IIIB patients. We performed 12 pneumonectomies, 1 bilobectomy, and 23 lobectomies. Status ypT0N0 was obtained for 35% of the patients. Surgery was considered R0 in 86% of the cases. Postoperative morbidity was 21.6% with a mortality of 10.8% (25% after pneumonectomy). OS was 50% at 5 years. The median RFS was 50 months. RFS was 47% at 5 years. Local or locoregional recurrence was diagnosed in 10.8% of the patients, and distant metastasis in 35.1%. Recurrence risk factors were pneumonectomy (p = 0.001) and a histologically incomplete response (p = 0.04).

Conclusion The TAXCIS protocol followed by surgery is feasible for initially unresectable NSCLC stage IIIA and B patients. Benefit was noted in responding lesions with better OS and PFS, except after pneumonectomy.
Therapie der ureteropelvinen Stenose im Erwachsenenalter
Authors: Mühlstädt Sandra , Kranz Jennifer , Steffens Joachim , Fornara Paolo
Published: October 2017

Die ureteropelvine Stenose, synonym Subpelvin- oder Nierenbeckenabgangsstenose, beschreibt eine Obstruktion im Bereich des pyeloureteralen Übergangs, in deren Folge eine renale Harnabflussstörung resultiert, die es zu behandeln gilt.

Seit der Erstbeschreibung der Pyeloplastik durch Trendelenburg 1886 und der erfolgreichen Etablierung durch Anderson und Hynes 1949 haben sich die Behandlungsstrategien der Nierenbeckenplastik vor allem in den letzten zwei Jahrzehnten weiterentwickelt. Zwar gilt die offene Pyeloplastik nach wie vor als Goldstandard, doch wird diese heutzutage durch moderne minimal-invasive Techniken ergänzt. Dies inkludiert u. a. die laparoskopische Pyeloplastik, laparoskopische Single-Site Pyeloplastik, roboter-assistierte Pyeloplastik, roboter-assistierte Single-Site Pyeloplastik sowie die Endopyelotomie.

Dieser Artikel gibt eine Übersicht über die Therapie der ureteropelvinen Stenose sowie das Komplikationsmanagement der Pyeloplastik im Erwachsenenalter.
Leitlinien in der Neurorehabilitation
Authors: Platz Thomas
Published: October 2017

Leitlinien sind wissenschaftlich fundierte Handlungsempfehlungen. Konsensbasierte Leitlinien können innerhalb einer Fachgesellschaft (S1-Leitlinie) oder mit einem strukturierten Konsensprozess fachgesellschaftsübergreifend (S2k-Leitlinie) entwickelt werden. S2k-Leitlinien sind bei komplexen Fragestellung oder bei geringer Evidenzbasis eine gute Möglichkeit, valide Empfehlungen für die klinische Praxis auf eine möglichst breite Basis zu stellen. Leitlinien, die auf einer systematischen Evidenzbasierung (Suche und Bewertung) basieren, stellen die höchste Qualitätsstufe dar (S2e innerhalb einer Fachgesellschaft, S3 fachgesellschaftsübergreifend). Sie basieren nachweislich auf dem Stand der Wissenschaft und geben hohe Sicherheit, dass ihre Empfehlungen eine optimierte Behandlung unterstützen. Die Deutsche Gesellschaft für Neurorehabilitation (DGNR) stellt mit ihren S2e-Leitlinien zur Schlaganfallrehabilitation (Arm, Mobilität, Spastik) Leitlinien mit qualitativem Alleinstellungscharakter in der Neurorehabilitation zur Verfügung.
Psychotherapie in der neurologischen Rehabilitation
Authors: Schmidt Roger , Piliavska Kateryna , Maier-Ring Dominik , Klaasen van Husen Dominik , Dettmers Christian
Published: October 2017

Dem Bedarf angepasste psychotherapeutische Maßnahmen gehören zum unverzichtbaren Behandlungsspektrum der Neurorehabilitation. Allein schon angesichts der großen Häufigkeit komorbider psychischer Störungen, die freilich nicht immer erkannt und angemessen behandelt werden. Die aktuelle Lage ist außerdem gekennzeichnet von einer großen Vielfalt angewendeter Verfahren und einem Mangel an Therapiestudien und gesicherter Evidenz. In diesem Stand der Dinge kommt freilich auch die Vielfalt und Komplexität neurologischer Erkrankungen zum Ausdruck. Zumal bei Vorliegen begleitender psychischer Störungen ist mit von mal zu mal anders akzentuierten Behandlungserfordernissen zu rechnen. Zugleich ist die bei einer Schädigung des ZNS besonders enge Verschränkung leiblicher und seelischer Funktionen zu beachten. Das alles macht eine gleichsam neurologische fundierte, multimodale Psychotherapie erforderlich, die unter Berücksichtigung der unterschiedlichen Behandlungsansätze und Verfahren in eine in sich stimmige, direkt in die weiteren neurorehabilitativen Maßnahmen integrierte Behandlung mündet. Vor diesem Hintergrund soll der Artikel für den nicht tagtäglich psychotherapeutisch arbeitenden Neurologen das Problembewusstsein dafür schärfen, dass psychische Komorbiditäten in der neurologischen Rehabilitation regelhaft vorkommen, entsprechende Behandlungsbedürfnisse aber häufig nicht erfüllt werden – verknüpft mit einem orientierenden Überblick über psychotherapeutische Aufgaben, Verfahren, Entwicklungserfordernisse und Perspektiven.
Das geriatrische Assessment nach Barthel (Barthel-Index,
BI)
Authors: Zemke Jens
Published: October 2017

Standardinstrument Assessment nach Barthel Der Barthel-Index wurde als
Kontrollparameter der Therapieabläufe in der geriatrischen Medizin entwickelt.
Mittlerweile ist er nicht mehr nur ein Instrument des multiprofessionellen
geriatrischen Teams, sondern zunehmend auch für die Kostenträger von Behandlung
und Rehabilitation. Hier im Fallbeispiel.
Nervenkompressionssyndrome – Wenn Nerven nerven
Authors: Paries Cornelia , Zander Andrea
Published: October 2017

In Unterarm und Hand verlaufen wichtige Nerven auf engstem Raum. Werden sie komprimiert, können nachhaltige Nervenschäden entstehen. Im zweiten Teil unseres Refreshers erfahren Sie mehr über die Befunderhebung sowie die therapeutischen Maßnahmen bei Nervenkompressionssyndromen der oberen Extremitäten.
Die Ronnie Gardiner Methode – Stampfen, klatschen, sprechen
Authors: Nürk Lisa
Published: October 2017

Auf Helene Fischers „Atemlos“ zu stampfen und zu klatschen, motiviert nahezu alle, die das erste Mal mit der Ronnie Gardiner Methode in Berührung kommen. Diese kombiniert den Rhythmus der Musik mit Bewegung und Gesprochenem und stimuliert damit verschiedene Regionen des Gehirns.
Pharmakologische Aspekte in der Neurorehabilitation
Authors: Hömberg Volker
Published: October 2017

Ärzte in der neurologischen Rehabilitation sind mit vielfältigen Aspekten der pharmakologischen Behandlung befasst. Über die Entscheidung angemessener antihypertensiver, antikonvulsiver oder antikoagulativer Behandlung hinaus ergeben sich aber zusätzliche Aspekte für die Hirnerholung positiv bzw. negativ beeinflussende pharmakologische Interventionen.

Von großer Wichtigkeit ist das Vermeiden sogenannter „Detrimental Drugs“ von deren pharmakologischen Profil klar ist, dass sie die Hirnerholung und Hirnreorganisation negativ beeinflussen. Dazu gehören klassische Antikonvulsiva wie Phenytoin und Barbiturate aber auch Benzodiazepine, Butophynone und Antihypertensiva wie Clonidin und Prazosin. Wenn irgend möglich sollte nach einer akuten neurologischen Hirnschädigung auf den Einsatz dieser Substanzen verzichtet werden.

Unter EBM-Kriterien konnte nur für Fluoxetin und Cerebrolysin bisher in größeren randomisiert kontrollierten Untersuchungen eine nachgewiesene Wirksamkeit zur Verbesserung der Funktionserholung nach Schlaganfall nachgewiesen werden. Beide Substanzen wirken offenbar auf multiple molekulare Mechanismen der Hirnerholung ein. Grundsätzlich kann der Einsatz von Antidepressiva (insbesondere SSRI) nach Schlaganfall auch bei nicht depressiven Schlaganfallpatienten zur Förderung der Funktionserholung empfohlen werden.

Auch der Einsatz von dopaminergen Substanzen zeigte in kleinen Studien positive Effekte auf die Funktionserholung nach Schlaganfall. Angesichts des geringen Nebenwirkungspotenzials kann der probatorische Einsatz von z. B. L-Dopa (100 mg am Tag) in der subakuten Phase nach Schlaganfall empfohlen werden.

Auch bei MS-Patienten kann der Einsatz von Antidepressiva zur Verbesserung der Lebensqualität empfohlen werden.

Bei Patienten mit eingeschränktem Bewusstseinszustand (Wachkoma, Minimal Conscious State) ist Amantadin bisher die einzige Substanz, für die in einer größeren randomisiert kontrollierten Studie eine zumindest transiente Wirksamkeit nachgewiesen werden konnte. Der Einsatz von Amantadin kann daher zur Verbesserung der Bewusstseinslage bei diesen Patienten empfohlen werden.
Roboter- und gerätegestützte Rehabilitation der oberen Extremität
Authors: Sailer Michael , Sweeney-Reed Catherine , Lamprecht Juliane
Published: October 2017

Eine standardisierte Therapie der oberen Extremität bei Patienten mit einer Störung des zentralen Nervensystems (ZNS) liegt bisher nicht vor. In der letzten Dekade hat die roboter- und gerätegestützte Therapie die Behandlung der motorischen Funktionsstörungen der oberen Extremität nach Schlaganfall in der Neurorehabilitation deutlich beeinflusst. Die vorliegende Arbeit gibt einen Überblick zu den technischen Grundlagen und zur Differenzierung der verschiedenen Gerätetypen. Unter Einbeziehung ausgewählter Studien wird die Praxis der roboter- und gerätegestützten Rehabilitation der oberen Extremität dargestellt. Die Effektivität der gerätegestützten Therapie der oberen Extremität ist, im Vergleich zu einer gleichwertig intensiven konventionellen Therapie, weiterhin diskutabel, nicht zuletzt auch aufgrund der recht heterogenen Studienlage. Dennoch weisen die Entwicklung und der Einsatz roboter- und gerätegestützter Therapieformen der oberen Extremität in eine vielversprechende Zukunft. Sie können das Personal entlasten und stellen aktuell eine sinnvolle Ergänzung zur konventionellen Therapie dar.
Ein Ergotherapeut in der beruflichen Reha – Kein Tag wie jeder andere
Authors: Stamm Anja
Published: October 2017

Mehr Zeit für Klienten, mehr Entscheidungsspielraum – das fordern Therapeuten seit langem. Ergotherapeut Marian Waßmann sieht in seiner heutigen Tätigkeit diese Wünsche erfüllt. Im Außendienst unterstützt er Menschen in der beruflichen Reha dabei, in ihren Arbeitsalltag zurückzufinden.
Komplexe Entscheidungen im Gesundheitswesen: Die Bewertung
und Saldierung von Nutzen und Schaden als Gegenstand der multikriteriellen
Entscheidungsanalyse
Authors: Mühlbacher Axel C. , Kaczynski Anika , Schmidt Katharina , Dintsios Charalabos-Markos
Published: October 2017

Verfahren der multikriteriellen Entscheidungsanalyse erlauben die Bewertung und
Saldierung von Nutzen und Schaden unter der Berücksichtigung von Präferenzen. Im
Gesundheitswesen können beispielsweise die Patienten- oder Expertenpräferenzen
in Bezug auf verschiedene Nutzen-, Schaden- oder Anwendungsaspekte einer
Gesundheitstechnologie im Entscheidungsprozess berücksichtigt werden. Mögliche
Ansätze zur Abwägung von Nutzen und Schaden einer Gesundheitstechnologie bieten
Methoden wie der Analytic Hierarchy Process oder das Discrete Choice Experiment.
Diese und andere Methoden erlauben den Vergleich einzelner Alternativen auf
Basis des Gesamtnutzens. Dabei werden verschiedenen Zielkriterien numerische
Teilnutzenwerte zugewiesen, welche in ein Gesamtmaß des Nutzens überführt
werden, um so den direkten Vergleich der unterschiedlichen Handlungsoptionen zu
ermöglichen.
Alpha mangostin Inhibits Hepatic Stellate Cells Activation Through TGF-β/Smad and Akt Signaling Pathways: An in vitro Study in LX2
Authors: Rahmaniah Rahmaniah , Yuyuntia Yuyuntia , Soetikno Vivian , Arozal Wawaimuli , Antarianto Radiana , Louisa Melva
Published: October 2017

Background Alpha mangostin has been reported to have activity for the treatment of liver fibrosis in the rats. However, the mechanisms of action are poorly understood. This study was aimed to investigate the effect of alpha mangostin on hepatic stellate cells (HSC) activation and proliferation through TGF-β/Smad and Akt signaling pathways.

Methods Immortalized HSC, LX2 cells, were incubated with TGF-β with or without alpha mangostin (5 or 10 μM). Sorafenib 10 µM was used as positive control. LX2 viability was counted using trypan blue exclusion method. The effect of alpha mangostin on TGF-β concentrations, and the expressions of proliferation and fibrogenic markers were evaluated.

Results Alpha mangostin treatment resulted in a reduced proliferation of HSC, decreased Ki-67 and p-Akt expressions. These findings were followed with decreased concentrations of TGF-β in the medium of cells treated with alpha mangostin, decreased expressions of COL1A1, TIMP1, PAI1, α-SMA, and p-Smad3 as fibrogenic markers. These effects were shown to be dose-dependent.

Conclusions Alpha mangostin inhibits hepatic stellate cells proliferation and activation through TGF-β/Smad and Akt signaling pathways in dose dependent manner.
Methodological Quality Assessment of Meta-Analyses of Hyperthyroidism Treatment
Authors: Qin Yahong , Yao Liang , Shao Feifei , Yang Kehu , Tian Limin
Published: October 2017

Hyperthyroidism is a common condition that is associated with increased morbidity and mortality. A number of meta-analyses (MAs) have assessed the therapeutic measures for hyperthyroidism, including antithyroid drugs, surgery, and radioiodine, however, the methodological quality has not been evaluated. This study evaluated the methodological quality and summarized the evidence obtained from MAs of hyperthyroidism treatments for radioiodine, antithyroid drugs, and surgery. We searched the PubMed, EMBASE, Cochrane Library, Web of Science, and Chinese Biomedical Literature Database databases. Two investigators independently assessed the meta-analyses titles and abstracts for inclusion. Methodological quality was assessed using the validated AMSTAR (Assessing the Methodological Quality of Systematic Reviews) tool. A total of 26 MAs fulfilled the inclusion criteria. Based on the AMSTAR scores, the average methodological quality was 8.31, with large variability ranging from 4 to 11. The methodological quality of English meta-analyses was better than that of Chinese meta-analyses. Cochrane reviews had better methodological quality than non-Cochrane reviews due to better study selection and data extraction, the inclusion of unpublished studies, and better reporting of study characteristics. The authors did not report conflicts of interest in 53.8% meta-analyses, and 19.2% did not report the harmful effects of treatment. Publication bias was not assessed in 38.5% of meta-analyses, and 19.2% did not report the follow-up time. Large-scale assessment of methodological quality of meta-analyses of hyperthyroidism treatment highlighted methodological strengths and weaknesses. Consideration of scientific quality when formulating conclusions should be made explicit. Future meta-analyses should improve on reporting conflict of interest.
Drop pattern resulting from the breakup of a bidimensional grid of liquid filaments
Authors: Cuellar Ingrith , Ravazzoli Pablo D. , Diez Javier A. , González Alejandro G.
Published: October 2017

A rectangular grid formed by liquid filaments on a partially wetting substrate evolves in a series of breakups leading to arrays of drops with different shapes distributed in a rather regular bidimensional pattern. Our study is focused on the configuration produced when two long parallel filaments of silicone oil, which are placed upon a glass substrate previously coated with a fluorinated solution, are crossed perpendicularly by another pair of long parallel filaments. A remarkable feature of this kind of grids is that there are two qualitatively different types of drops. While one set is formed at the crossing points, the rest are consequence of the breakup of shorter filaments formed between the crossings. Here, we analyze the main geometric features of all types of drops, such as shape of the footprint and contact angle distribution along the drop periphery. The formation of a series of short filaments with similar geometric and physical properties allows us to have simultaneously quasi identical experiments to study the subsequent breakups. We develop a simple hydrodynamic model to predict the number of drops that results from a filament of given initial length and width. This model is able to yield the length intervals corresponding to a small number of drops, and its predictions are successfully compared with the experimental data as well as with numerical simulations of the full Navier–Stokes equation that provide a detailed time evolution of the dewetting motion of the filament till the breakup into drops. Finally, the prediction for finite filaments is contrasted with the existing theories for infinite ones.