bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical spectrum and short-term outcome of post-COVID multisystem inflammatory syndrome in children after the 2019 pandemic: a longitudinal cohort study
Authors: Kumar Sudesh , Bhattacharya Piyali , Arya Nikhil , Kumari Anamika , Chattopadhyay Nandita
Published: July 2024

Background As a post-COVID complication in children, multisystem inflammatory syndrome in children (MIS-C) is important because of its varied and life-threatening manifestations. With this background, this study attempts to focus on MIS-C cases in an underprivileged rural setting in north-eastern India, with most patients being treated with methylprednisolone rather than intravenous immunoglobulin due to financial constraints. Methods In this prospective longitudinal cohort study at MGM Medical College, 27 MIS-C cases diagnosed following WHO criteria were included. Laboratory and radiological investigations, including echocardiography, were performed as required for diagnosis and to assess prognosis. Most patients were treated with methylprednisolone. A follow-up assessment was done six weeks after discharge for any residual impairment. Results The most frequently affected age group was 5–10 years (59.28%), while respiratory (48.14%) and cardiac (40.74%) were the most commonly involved systems. Logistic regression studies established a significant association between serum ferritin level and prolonged hospital stay (coefficient 0.0674, p=0.0041), possibly due to greater complications in cases with high ferritin levels. Organ impairment was found to increase the need for inotrope use (coefficient 3.8797, p=0.00584). Most cases were treated with methylprednisolone alone (85.18%) with a favourable response and no death occurred. Conclusion The favourable response in cases treated with methylprednisolone only affirms the effectiveness of the drug as a cheaper alternative in a resource-poor setting. The study highlights that higher ferritin levels in complicated cases leads to prolonged hospitalisation and the increased need for inotropes in cases with organ impairment.
Case Report: Ludwig's angina - 'The Dangerous Space'
Authors: Vasanth Satish , Chandran Satheesh , Pandyan Deepak Abraham , Gnanam Padmashini , Djearamane Sinouvassane , Wong Ling Shing , Selvaraj Siddharthan
Published: July 2024

Background: Ludwig's angina is a potentially life-threatening disease characterized by diffuse bilateral cellulitis with an odontogenic origin. This unique infection is now rare owing to the antibiotic era. Case: This patient presented to the emergency room with trismus, jaw and neck swelling, mild respiratory distress with tachypnea, hyperthermia, and panic. Clinical examination and radiographic evaluation confirmed the diagnosis of Ludwig's angina. As it is a quickly spreading infection, the patient was taken up for immediate surgical decompression leading to pus drainage, removal of the offending tooth, bacterial culture and sensitivity, and administration of empirical antibiotics. As we had operated promptly, there was no need for emergency airway intervention, and the patient had immediate relief from airway distress. Conclusions: Early accurate diagnosis with conservative surgical decompression, thereby negating the need for airway intervention, was vital to avoiding mortality which is always possible in such an expeditious infection.
Return to work rate of individuals after cardiac rehabilitation and the demographic and impairment factors that influence return to work in the Western Cape, South Africa
Authors: Ganie Zakeera , Soeker Shaheed , Rhoda Anthea
Published: July 2024

Background Cardiovascular disease (CVD) commonly affects individuals within the working age group, often resulting in unemployment, particularly in low- to middle-income countries. The purpose of the study was to determine the return to work (RTW) rate of individuals with CVD after cardiac rehabilitation (CR) and the impact of impairment and socio-demographics on the individual’s ability to (RTW). Methods A cross-sectional survey, namely the Work Rehabilitation Questionnaire (WORQ) was used to gather the information. The IBM SPSS software (version 25) was used to manage the statistical analysis. Individuals who completed a CR program between the ages of 18 and 64 years made up a sample of 63 research participants. Results The RTW rate reported that only 30 (47.6%) of the participants successfully RTW after CR and 33 (52.4%) of participants did not RTW. The results also indicated that the older the individual and the higher the degree of impairment experienced, the less likely RTW would occur. Conclusion Factors such as the age and level of functional impairment of the individual with CVD must be addressed more aggressively in CR programs, particularly if the goal of the individual with CVD is to RTW.
Efficacy of Lycium barbarum (Goji berry) mouthwash for managing periodontitis: a randomized clinical trial
Authors: Sanghavi Amee , Shettigar Laasya , Chopra Aditi , Shah Ashmeet , Lobo Richard , Shenoy Padmaja A , Gadag ShivaPrasada , Nayak Usha Y , Shravya S Mangalore , Kamath Shobha Ullas , Nayak Prajna P
Published: July 2024

Background Removal of the microbial deposits (plaque and calculus) by performing effective scaling and root planing (SRP) is the fundamental step for managing periodontal disease (gingivitis and periodontitis). Various adjuncts in the form of mouthwash, gels, and toothpaste are also being used as adjuncts to SRP for managing periodontitis. Recently, Lycium barbarum (L. barbarum), commonly known as goji berry or wolfberry, has gained popularity for managing chronic inflammatory and infectious diseases. However, its efficacy in managing periodontitis has never been explored. Hence the present study aims to evaluate the efficacy of goji berry mouthwash compared to chlorhexidine mouthwash for managing periodontitis. Methods 60 adult participants were divided randomly using computer-generated random sequences into two groups (case group: L. barbarum mouthwash (Males: 16; Female: 14); control group: 0.2% chlorhexidine gluconate mouthwash (Males: 14; Females: 16)). The changes in the gingival index (Gi), plaque index (Pi), bleeding on probing (BOP), clinical attachment loss (CAL), probing pocket depth (PPD), microbial load, and antioxidant levels (protein thiol) in saliva were noted at the baseline, at 15 days and one month. Results A significant reduction in the mean PPD, Pi, and Gi was seen from baseline to one month in both the control (P-value=0.006, 0.027, and 0.036 respectively) and test groups (P-value=0.035, 0.000, and 0.000 respectively). CAL was reduced significantly only in the control group. However, the antioxidant levels (protein thiol) in saliva were significantly increased only in the test group. Conclusion Goji berry mouthwash along with SRP reduced the Gi, Pi, BOP, and PPD in patients with periodontitis. However, no statistically significant difference was noted between the use of goji berry and chlorhexidine mouthwash. Goji berry mouthwash was more effective than chlorhexidine in increasing the antioxidant levels in saliva.
The identification of high-performing antibodies for Sequestosome-1 for use in Western blot, immunoprecipitation and immunofluorescence
Authors: Ayoubi Riham , Alshafie Walaa , Shlaifer Irina , Southern Kathleen , McPherson Peter S. , Laflamme Carl ,   NeuroSGC/YCharOS/EDDU collaborative group
Published: July 2024

Sequestosome-1, encoded by the gene SQSTM1, functions as a bridge between ubiquitinated proteins and the proteasome or autophagosome, thereby regulating protein degradation pathways. Loss of Sequestosome-1 is hypothesized to enhance neurodegeneration progression in several diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal disorders (FTD). Sequestosome-1 reproducible research would be facilitated with the availability of well-characterized anti-Sequestosome-1 antibodies. In this study, we characterized seventeen Sequestosome-1 commercial antibodies for Western blot, immunoprecipitation, and immunofluorescence using a standardized experimental protocol based on comparing read-outs in knockout cell lines and isogenic parental controls. We identified many high-performing antibodies and encourage readers to use this report as a guide to select the most appropriate antibody for their specific needs.
The legal and institutional framework for the protection of religious rights in Nigeria and the right to wear Hijab in public institutions.
Authors: ELIKWU CAESAR    MANUCHIMSO , Olujobi Olusola Joshua , YEBISI EBENEZER   TUNDE
Published: July 2024

Background Religion and its exercise are among the most sensitive discourses in different parts of the world, especially in Nigeria. The constitution and other laws ensure citizens are afforded basic human rights of which religious rights are included and yet regulated. There are questions of interpretation as to the extent to which such rights can be enjoyed and the efficacy of both the legal and institutional frameworks protecting religious rights in Nigeria. Methods This article utilises a doctrinal legal research approach utilising existing literature, statutes, and laws enacted towards the protection of religious rights in Nigeria with the consideration of primary and secondary sources of statutes including the 1999 Constitution of the Federal Republic of Nigeria (as amended), judicial precedents, International Conventions, law textbooks, and peer-reviewed journals. A comparative analysis of Nigeria, Tunisia, Algeria, Turkey and Kazakhstan was done to gain perspectives on balancing conflicting interests in light of Nigeria’s heterogeneous status. As part of the contribution to knowledge, a hybrid model for mitigating the socio-legal effect of the usage of hijab in Nigeria’s public institutions is presented to further enrich Nigeria’s jurisprudence. A hybrid model is an approach that combines different sources or methodologies by integrating two or more distinct frameworks to leverage their strengths and effectively address specific needs or challenges. It is utilized to achieve synergy and maximize outcomes by blending diverse legal approaches in law. Results Nigeria, being a multi-ethnic and multi-religious state, demonstrates that the government must protect the public interests as it relates to religious rights regardless of faith or religion. The study reveals that the current legal approach without further legislative intervention on religious issues will be inadequate to address the problem. Therefore, this study presents a hybrid model for mitigating the socio-legal effect of the usage of hijab in Nigeria’s public institutions to avoid harm and further enrich Nigeria’s jurisprudence. Conclusions This study concludes by emphasizing the inadequacy of Nigeria’s legal and institutional frameworks regarding the protection of religious rights and the right to wear hijab in public institutions. Consequently, reform is deemed necessary.
Comparative evaluation and co-relation in variation of curve of Spee and curve of Wilson in Class II div. 1, Class II div. 2, and Class III as against Class I malocclusion in central India population- an in vitro study
Authors: Pandey Ruchika , Kamble Ranjit
Published: July 2024

Introduction Getting acceptable cosmetic results in the soft tissues of the face serves as the foundation for orthodontic treatment planning. Also, in order to achieve healthy static and dynamic occlusal interactions, the teeth must be positioned within the basal bone at the correct position, angle, and inclination. To avoid periodontal issues, provide stability, and achieve a functional occlusion, it is essential to ascertain the individual’s dental arch form before starting of treatment and thus to utilise the mechanics that follow throughout the treatment. Objectives To evaluate and compare variation in Curve of Spee and Curve of Wilson in Class II Div.-1, Class II-Div-2 and Class-III as against Class I malocclusion in central India population. Methodology Irreversible hydrocolloid impression will be taken with perforated metal stock trays and stone cast will be poured. This will be scanned using CAD CAM machine and curve of Spee and Wilson will be measured using reverse engineering. Expected Result It will assist us in treatment planning for preventing periodontal issues, assuring stability, and achieving functional occlusion by evaluating and comparing the Spee and Wilson curves in Class II Divison-1, Class II Divison-2, and Class-III malocclusion with Class-I malocclusion. Conclusion Every single patient receiving orthodontic treatment has the COS, which is crucial to achieving a stable occlusion. Almost every patient who receives orthodontic treatment eventually experiences the Spee Curve. Since there aren’t many studies examining the relationship between the Curves of Spee and Wilson, their impact on dentoskeletal morphology, and their role in occlusal stability.
How useful is the tuberculin skin test for tuberculosis detection: Assessing diagnostic accuracy metrics through a large Tunisian case-control study
Authors: Nouira Mariem , Ben Rayana Hazem , Ennigrou Samir
Published: July 2024

Background and aim During the past decade, the frequency of extrapulmonary forms of tuberculosis (TB) has increased. These forms are often miss-diagnosed. This statement of the TB epidemiological profile modification, conduct us to reflect about the utility of the Tuberculin Skin Test (TST) in active TB detection. This study aimed to evaluate the diagnostic accuracy performance of the TST for active tuberculosis detection. Methods This was a case-control, multicenter study conducted in 11 anti-TB centers in Tunisia (June-November2014). The cases were adults aged between 18 and 55 years with newly diagnosed and confirmed tuberculosis. Controls were free from tuberculosis. A data collection sheet was filled out and a TST was performed for each participant. Diagnostic accuracy measures of TST were estimated using Receiver Operating Curve (ROC) curve and Area Under Curve (AUC) to estimate sensitivity and specificity of a determined cut-off point. Results Overall, 1050 patients were enrolled, composed of 336 cases and 714 controls. The mean age was 38.3±11.8 years for cases and 33.6±11 years for controls. The mean diameter of the TST induration was significantly higher among cases than controls (13.7mm vs.6.2mm; p=10-6). AUC was 0.789 [95% CI: 0.758-0.819; p=0.01], corresponding to a moderate discriminating performance for this test. The most discriminative cut-off value of the TST, which was associated with the best sensitivity (73.7%) and specificity (76.6%) couple was   ≥ 11 mm with a Youden index of 0.503. Positive and Negative predictive values were 3.11% and 99.52%, respectively. Conclusions TST could be a useful tool used for active tuberculosis detection, with a moderate global performance and accepted sensitivity and specificity at the cut-off point of 11 mm. However, it cannot be considered as a gold standard test due to its multiple disadvantages.
Case Report: Bell’s palsy: a neurological manifestation of COVID-19 infection
Authors: Abdelrahman Amro , Bitar Amira , Babiker Isra , Elgak Fawaz , Elgassim Mohamed
Published: July 2024

Background Coronavirus (COVID-19) is the causative agent of the most recent pandemic that hit the globe and has been the cause of a vast range of symptoms, including neurological symptoms. Bell’s palsy is an acute peripheral facial paralysis commonly associated with viral infections. Case presentation This case report describes a patient with incidental COVID-19 infection that led to acute unilateral peripheral facial paralysis, Bell’s palsy. Our patient is a 35-year-old male with no known comorbidities who was presenting with upper respiratory tract infection symptoms and was found to be positive for COVID-19. Soon after the onset of symptoms, he also developed right-sided facial weakness in association with his symptoms. A thorough examination revealed a peripheral neurological lesion. The diagnosis of Bell’s palsy secondary to COVID-19 virus infection was through the exclusion of other possible causes. Conclusions This case report suggests a potential link between Bell’s palsy and COVID-19, highlighting the importance of a comprehensive understanding of the neurological manifestations of COVID-19. Further research is essential to determine the significance of neuropathies in COVID-19 and enhance treatment strategies.
Diagnosis and Molecular Characterization of Dermatophytosis: An Observational Study
Authors: Warghade Aditi , Mudey Gargi
Published: July 2024

Dermatophytes are the keratinophilic fungi which infect humans and is the most recurring type of disease. The high level of transmissibility creates an epidemiological risk and emphasises the significance of these illnesses. However, a growing number of reports describing dermatophytes can cause deep infections in diabetic and immunocompromised patients, by invading deep layers like the dermis and hypodermis. Despite the prevalence and significance of dermatophytes in clinical mycology, it is not always possible to accurately diagnose this specific infection due to its overlapping structures among species of dermatophytes. Since it is difficult to identify species that exhibit weak characteristics in the morphological highlights, identification of the dermatophyte is often relied on its morphological analysis, which is a laborious process and demands skill. The massive shift in genetic variation, the source of infection, and epidemiological research can be discovered using molecular approaches. Therefore, the development of an accurate laboratory test for dermatophyte species identification is essential for the prevention and efficient management of dermatophytoses. One such methodology allows use of PCR technology which has many methods for molecular level characterization which is rapid, efficient, and capable of producing DNA polymorphisms specific to various dermatophyte species based on distinctive band patterns seen by agarose gel electrophoresis. The RAPD-PCR approach will be used in this study protocol to molecularly characterize the dermatophytes for precise speciation of the sample. In addition to improving knowledge of fungal biology and pathology with a focus on adaptive mechanisms to combat difficult conditions from host counteractions, there is a need to improve awareness of the importance of these diseases through accurate epidemiological data. The advantages of molecular approaches for characterizing objects over traditional methods are their sensitivity and specificity.
Case Report: Tongue deviation due to supranuclear injury with a rare semiological feature
Authors: Santander Maury Mayra Alejandra , Muñoz Rodriguez Sergio Andres , Camargo Camargo Loida
Published: July 2024

Abstract* Hypoglossal nerve injuries are classified according to their anatomical localization in: Infranuclear, nuclear, and supranuclear. Supranuclear injuries can occur in cerebral cortex, corticobulbar tracts, internal capsule, cerebral peduncles, or in the pons, and most often caused by a stroke. These lesions usually do not generate a significant alteration of tongue motility due to the bilateral innervation of both nuclei from the cortex. We present a case of a 43-year-old male with dysarthria, left central facial paralysis, and an important tongue palsy and deviation to the same side. Brain CT revealed a right frontotemporal stroke with little hemorrhagic transformation, and an EKG that showed auricular fibrillation. He received treatment with amiodarone and rivaroxaban was initiated when a second brain CT scan showed no evidence of hemorrhage. This case is remarkable due the unusual presentation in a supranuclear lesion of the hypoglossal nerve. It is important to enrich the semiology and consider the possibility of cortical cerebrovascular events in patients with acute deviation of the tongue, even in the absence of involvement of other cranial nerves; or marked ipsilateral motor implication.
Causal relationship between financial deepening, national security, ecological footprint, and economic growth in Nigeria
Authors: Manasseh Charles O. , Logan Chine Sp , Okanya Ogochukwu C. , Ede Kenechukwu K. , Onuselogu Odidi C..O. , Ngong Chi  A. , Duru John C. , Ogbuabor Jonathan E. , Nwakoby Ifeoma C.
Published: July 2024

Background This study seeks to examine the causal link between financial deepening, national security, ecological footprint, and economic growth in Nigeria, in order to contribute to the contradicting evidence on economic growth drivers. Methods The dynamic ARDL model was employed as the baseline model to establish the link between the phenomena, and the FMOLS and DOLS as robust models using time series data spanning from 1995 to 2022. The FMOLS and DOLS models take into consideration the presence of endogeneity, cross-sectional dependency, and heterogeneity. Results The results demonstrate that whereas ecological footprint has positive and significant long-term relationships with economic growth, financial deepening and national security have negative and significant long-run relationships with economic growth. There was a 34% and 50% correction to the short-term to long-term adjustment speed, respectively. The findings of the Granger causality, interaction terms, marginal (ME), and threshold (TH) effects demonstrate: a) a significant bidirectional causal relationship between national security and economic growth, as well as a one-way significant causal link between financial deepening and economic growth; b) changes in national security and ecological footprint have a significant and negative impact on the financial deepening effect on economic growth; c) significant negative and marginal effects of national security on economic growth, as well as significant positive marginal effects of ecological footprints on economic growth; and d) the impact of financial deepening on economic growth becomes apparent when the increases in the marginal effect of the ecological footprint reach a critical limit over the ( TH CO 2 = 0.981) threshold. Conclusions This study highlights the significant link between Nigeria’s financial deepening, national security, ecological footprint, and economic growth. It recommends that viable policies be put in place to support the development of financial institutions, increasing security infrastructure investment, and promoting renewable energy use for sustainable environment and reduced carbon emissions.
Effect of skill-based educational training for ambulance personnel on neonatal transport for newborn care in coastal South India – a single arm intervention study
Authors: Kalyan Santosh , Kamath Sowmini Padmanabh , Shetty S Subhodh , Holla Ramesh , Lewis Leslie , Lashkari P Harsha , Shenoy M Suchitra , Baliga B Shantharam
Published: July 2024

Background Education of ‘108' ambulance personnel involved in transporting neonates may improve outcomes. We assessed i) perceptions/practices of ‘108’ ambulance personnel for transporting neonates, ii) clinical parameters of transported neonates at arrival, and iii) outcomes such as survival/mortality and NICU stay (before and after skill-based educational intervention). Methods We conducted a single-arm intervention study (pre-and post) over 18 months. We assessed the perceptions and practices of 77 ambulance personnel on neonatal transport pre- versus post-intervention. Checklists assessed ambulance equipment availability/usage in both phases. We compared clinical parameters and outcomes of transported neonates between the pre-intervention (n=62) and post-intervention (n=53) phases. We analyzed data using SPSS version 25. Results Post-intervention, there was a significant reduction in the levels of hypothermia (p < 0.001), hypoglycemia (p=0.010), and prolonged capillary refill time (p=0.042), along with improvement in the use of intravenous fluids (p <0.001), a reduction in the positivity of umbilical swab growth (p=0.002) and in the duration of NICU stay (p = 0.001), significant improvement (p < 0.001) in the perceptions/practices of ambulance personnel towards neonatal transport. There was an improvement in the ambulance equipment availability/usage post-intervention. Conclusions The perceptions and practices of the ‘108’ ambulance towards transporting neonates had significantly improved post-educational intervention. Further, a significant decrease in hypothermia, hypoglycemia, and duration of NICU stay was seen in neonates transported post-intervention.
Evaluating the dynamics of fee-free higher education in South Africa: a causal loop diagram approach
Authors: Ramasu Tlotlo , Kanakana-Katumba Grace
Published: July 2024

Background This research investigated the dynamics of fee-free higher education in South Africa, aiming to elucidate the complexities surrounding its implementation and impact. By employing a causal loop diagram approach, the study examined the interplay of socioeconomic, political, and institutional factors influencing the provision of fee-free higher education. Method A participatory approach to developing the CLD was used. Through an extensive literature review, the research contextualised fee-free higher education enabling a preliminary CLD to be developed. Discussions were held to improve the preliminary model based on stakeholder and expert opinion. The model was then validated by stakeholders and experts. Results The CLD has explicitly mapped out the causal relationships which play a fundamental role in fee-free higher education in South Africa. Key findings revealed that fee-free higher education initiatives, such as managing funding constraints and administrative complexities, hold promise for fostering inclusivity and socioeconomic development but are hindered by bureaucratic policy establishments and inefficiencies. These challenges underscore the gap between policy formulation and implementation, highlighting the need for comprehensive reforms to streamline administrative processes and enhance financial sustainability within the higher education sector. Conclusion This research thoroughly examined the dynamics of fee-free higher education in South Africa, highlighting both the challenges and opportunities in its implementation. The study emphasized the need for systemic reforms to improve accessibility and effectiveness, while also underscoring the potential of such initiatives to promote social mobility and economic empowerment, aligning with global goals like the SDGs and the African Agenda 2063.
Roles and Current Challenges of Peer Educators in delivering HIV/AIDS-related services: a case study in VietNam
Authors: Thanh Hua Thuy , Thu Nguyen Ha , Thu Nguyen Huyen , Thi Hue Cao Chi , Thanh Nguyen Huong
Published: July 2024

Background Increasing the participation of peer educators (PEs) to deliver HIV/AIDS services in a limited income context remains challenging, despite their profound effectiveness, and this has become more evident since the COVID-19 outbreak. This study examines the roles of PEs and the current challenges in delivering HIV/AIDS services in Vietnam. Methods A mixed-method approach was employed. The study was conducted in seven large provinces in Vietnam from December 2021 to March 2022. An online cross-sectional survey was administered to 63 health staff and 147 PEs to collect quantitative data on PEs’ roles. Qualitative interviews included seven focus-group discussions with 39 PEs and in-depth interviews with 25 key informants, including seven leaders and 14 health staff from district health centers and provincial centers for disease control (CDCs), one national-level HIV/AIDS program manager, one non-government organization representative, and two senior experts. Results Results show the diversified roles of PEs in delivering HIV/AIDS activities in Vietnam. The roles could be categorized into two main groups, including community-based activities and facilities-based activities. Prominent roles are identifying and referring customers to HIV testing services, conducting communication and education activities, and referring patients to treatment services. The study shows a decrease in the roles of PEs in delivering HIV/AIDS services in Vietnam despite the high demand for their participation from healthcare providers. Critical challenges in employing PEs in HIV/AIDS services are related to lack of funding, inadequate training, lack of recognition, and stigma. Conclusion To keep the right path to the goal of ending the HIV pandemic by 2030, it is important to maintain and increase the roles of PEs in delivering HIV/AIDS services. Raising better acknowledgment from stakeholders of PEs’ roles could help overcome the remaining challenges and expand their participation toward this goal.
Physical activity and sedentary behavior perceptions in overweight and obese adults: A systematic review of qualitative study
Authors: Bora Neha , K Vaishali , Verma Ashwani , Bharti Avinash Kumar , Sinha Mukesh Kumar
Published: July 2024

Background One of the largest hazards to human health is obesity, which is intimately related to sedentarism and physical inactivity. Understanding the perspectives and attitudes of adults with overweight or obesity towards their lifestyle choices related to sedentary behavior and physical activity is essential for mitigating associated health risks. Objective This systematic review aims to collate the extent of qualitative research on the perception of sedentary behavior and physical activity among adults with overweight and obesity. Methods A comprehensive search of Scopus, PubMed, CINAHL, and Web of Science, databases was conducted, which yielded 2,881 articles. A total of 2591 abstracts were screened, and 45 full-text articles were examined. A total of nine qualitative studies involving adults with overweight or obesity (BMI > 25 kg/m2) were included in this systematic review. Data extraction utilized Rayyan.qcri.org software, and studies were critically appraised using Joanna Briggs’s Institute checklist for qualitative research. Results The included studies revealed a diverse array of themes, wherein a few perceived factors reported towards sedentary behavior were lack of awareness about the hazards, mode of relaxation, family commitment, technology use, motivation deficits, and fatigue. Barriers to physical activity encompassed social, cultural, and environmental factors. In contrast, peer support, fitness facility access, accountability, mental health awareness, well-being, and weight management facilitate physical activity involvement. Conclusion Perceptions in overweight and obese adults on sedentary living and exercise are intricate and multifaceted. This review provides valuable insights that can inform clinicians and researchers in promoting regular physical activity for adults with overweight and obesity.
Management of Strangulated Richter’s Hernia in a Resource-Limited Setting: Report of Two Cases and Literature Review
Authors: Boka Tounga Yahouza , Issoufou Hamma Ousmane , Zabeirou Aliou , Ide Kadi , Sani Rachid
Published: July 2024

Richter’s hernia is a rare type of abdominal wall hernia characterized by high morbidity and mortality. It occurs when the anti-mesenteric border of the bowel is partially trapped in a tight hernial ring. The femoral ring is the most common site, with the ileum being the most frequently involved intestinal segment. However, the advent of laparoscopic surgery has introduced another potential site for Richter’s hernia formation. In our region, this pathological entity is exceptionally diagnosed due to limited access to abdominal imaging and delayed management. Additionally, the wide variety of clinical manifestations resulting from incomplete intestinal obstruction makes it particularly difficult to diagnose. Consequently, it is usually identified during surgery. We present here the case of two adult patients (a 33-yeairs-old woman and a 59-year-old man), the first with a history of surgical procedures and the second with a spontaneously reducible painless inguinal swelling. They were transferred to the surgical emergency department for an acute abdomen with abdominal distension and cessation of matter and gas. Clinical and paraclinical examinations (including hydroaeric level on abdominal X-ray) indicated mechanical intestinal obstruction. Emergency laparotomy, necessitated by the unavailability of abdominal computed tomography due to financial constraints, confirmed the diagnosis of Richter's hernia, with the first case located in the right inguinal region and the second in the linea alba. Surgical management involved reduction of the hernia contents and suture repair in both cases. Despite requiring bowel resection in the second patient, the postoperative course was straightforward. These two rare cases highlight that emergency exploratory laparotomy is the cornerstone of Richter hernia management in resource-limited conditions.
Real Customization or Just Marketing: Are Customized Versions of Generative AI Useful?
Authors: Garrido-Merchán Eduardo C. , Arroyo-Barrigüete Jose Luis , Borrás-Pala Francisco , Escobar-Torres Leandro , Martínez de Ibarreta Carlos , Ortíz-Lozano Jose María , Rua-Vieites Antonio
Published: July 2024

Abstract* Background Large Language Models (LLMs), as in the case of OpenAITM ChatGPT-4TM Turbo, are revolutionizing several industries, including higher education. In this context, LLMs can be personalised through a fine-tuning process to meet the student demands on every particular subject, like statistics. Recently, OpenAI launched the possibility of fine-tuning their model with a natural language web interface, enabling the creation of customised GPT versions deliberately conditioned to meet the demands of a specific task. Methods This preliminary research aims to assess the potential of the customised GPTs. After developing a Business Statistics Virtual Professor (BSVP), tailored for students at the Universidad Pontificia Comillas, its behaviour was evaluated and compared with that of ChatGPT-4 Turbo. Firstly, each professor collected 15-30 genuine student questions from “Statistics and Probability” and “Business Statistics” courses across seven degrees, primarily from second-year courses. These questions, often ambiguous and imprecise, were posed to ChatGPT-4 Turbo and BSVP, with their initial responses recorded without follow-ups. In the third stage, professors blindly evaluated the responses on a 0-10 scale, considering quality, depth, and personalization. Finally, a statistical comparison of the systems’ performance was conducted. Results The results lead to several conclusions. Firstly, a substantial modification in the style of communication was observed. Following the instructions it was trained with, BSVP responded in a more relatable and friendly tone, even incorporating a few minor jokes. Secondly, when explicitly asked for something like, “I would like to practice a programming exercise similar to those in R practice 4,” BSVP could provide a far superior response. Lastly, regarding overall performance, quality, depth, and alignment with the specific content of the course, no statistically significant differences were observed in the responses between BSVP and ChatGPT-4 Turbo. Conclusions It appears that customised assistants trained with prompts present advantages as virtual aids for students, yet they do not constitute a substantial improvement over ChatGPT-4 Turbo.
Lifecourse research in cancer: context, challenges, and opportunities when exploring exposures in early life and cancer risk in adulthood
Authors: Baker Jennifer L. , Gordon-Dseagu Vanessa L.Z , Voortman Trudy , Chan Doris , Herceg Zdenko , Robinson Sian , Norat Teresa , Croker Helen , Ong Ken , Kampman Ellen
Published: July 2024

As the global population ages, and rates of modifiable risk factors for cancer change, cancer incidence and mortality continue to increase. While we understand many modifiable risk factors related to diet, nutrition, bodyweight, and physical activity in adulthood that influence cancer risk, how exposure during childhood, adolescence, and young adulthood impacts cancer risk is less clear. This is partly because the timeline from initial mutation to cancer development and diagnosis can span several decades. This long latency period creates methodological, ethical, and financial issues; as well as resource and feasibility challenges in the design, implementation, and data analysis of lifecourse studies. As such, the large majority of lifecourse studies are observational, often using recall data which has inherent bias issues. Concurrently, a new research era has begun, with mature birth cohort studies that are phenotyped/genotyped and can support studies on adult cancer risk. Several studies and consortia contain information spanning the lifecourse. These resources can support association, mechanistic and epigenetic investigations into the influences of multi-disciplinary (e.g. genetic, behavioural, environmental) factors, across the lifecourse and critical time periods. Ultimately, we will be able to produce high-quality evidence and identify how/when early life risk factors impact cancer development and survival.
An EDucation and eXercise intervention for gluteal tendinopathy in an Irish setting: a protocol for a feasibility randomised clinical trial (LEAP-Ireland RCT)
Authors: Almousa Sania , Vicenzino Bill , Mellor Rebecca , Grimaldi Alison , Bennett Kathleen , Doyle Frank , McCarthy Geraldine M. , McDonough Suzanne M. , Ryan Jennifer M. , Lynch Karen , Sorensen Jan , French Helen P.
Published: July 2024

Background Gluteal tendinopathy (GT) is a degenerative tendon condition characterised by pain over the greater trochanter of the hip. A randomised controlled trial (RCT) in Australia found that 14 sessions of EDucation on load management plus eXercise (EDX) delivered over 8 weeks resulted in greater improvements in global rating of change and pain outcomes at 8 and 52 weeks, compared with corticosteroid injection or ‘wait and see’. Typically, 5-6 physiotherapy sessions are provided in public and private physiotherapy settings in Ireland, therefore, the aim of this study is to examine the feasibility of conducting a future definitive RCT to investigate effectiveness of 6 sessions of the EDX programme compared to usual care. Methods We will randomly allocate 64 participants with GT to physiotherapist-administered EDX or usual care. The EDX intervention (EDX-Ireland) will be delivered in 6 sessions over 8 weeks. To determine feasibility of an RCT, we will assess recruitment and retention and outcome measure completion. The health status outcomes to be assessed at baseline, 8 weeks and 3 months include: Global Rating of Change, pain severity, the Victorian Institute of Sport Assessment-Gluteal Questionnaire (VISA-G), the Patient-Specific Functional Scale, the Pain Catastrophizing Scale, Patient Health Questionnaire (PHQ), Pain Self-Efficacy Questionnaire, the EQ-5D-5L, the Central Sensitisation Inventory and hip abductor muscle strength. We will explore acceptability of the EDX-Ireland intervention from the perspective of patients and treatment providers, and the perspective of referrers to the trial. A Study Within A Trial will be also applied to compare recording of exercise adherence using app-based technology to paper diaries. Discussion There is a need to establish effective treatments for GT that potentially can be implemented into existing health systems. The findings of this feasibility trial will inform development of a future definitive RCT. Registration The trial is registered prospectively on ClinicalTrials.gov (NCT05516563, 27/10/2022).
Graduate and Undergraduate Medical Curricula That Address the Needs of People Who Experience Homelessness: A Scoping Review Protocol
Authors: Linvill Matthew , Verlaque Logan , O’Sullivan Caitríona , Manocchio Felicia , King Matthew , Mabbott Connor , Walsh Aisling , Cousins Gráinne
Published: July 2024

Background The impact that increased homelessness has on the healthcare system should be of great concern to medical providers and the institutions that train them. While the demand for medical providers who understand the healthcare needs of homeless individuals is high, traditional medical curricula do not adequately address this. Objectives This scoping review aims to examine published undergraduate and graduate medical curricula that address the healthcare needs of homeless individuals to support the development and evaluation of homeless healthcare curricula globally. Methods This paper will utilise Arksey & O’Malley’s framework for scoping reviews to ensure a systematic scoping review. Research will be conducted in accordance with the Joanna Briggs Institute's (JBI) Updated Methodological Guidance for the Conduct of Scoping Reviews and the Preferred Reporting Items for Systematic Reviews and Meta-analyses Extension for Scoping Review (PRISMA-ScR). Due to financial and time constraints, only articles published after 2000 and written in English will be reviewed. A comprehensive search strategy will be developed that includes searches in PubMed, Scopus, Embase and CINAHL with additional hand-searching of key articles. Each article will be screened independently by two reviewers. A third reviewer will resolve any disagreements. Data extraction will begin with a pre-defined extraction form (Extended Data File 3) and will be subsequently analysed with JBI’s current guidelines on inductive approaches to qualitative content analysis. Conclusion Research findings will be distributed to individuals who oversee the university’s medical curricula at the Royal College of Surgeons in Ireland (RCSI) University of Medicine and Health Sciences. Discussions will be held to assess opportunities for the implementation/integration of homeless healthcare curricula. Furthermore, these findings will be disseminated globally to healthcare providers and administrators at conferences, hospitals and clinics.
Readiness for clinical practice: Self-perceived confidence of final year dental students in Turkey - A multi-institutional study
Authors: Altan Halenur , Gönder Hakan Yasin , Demirel Elif , Altan Ahmet , Tunçdemir Ali Rıza , Zahra Daniel , Al Maweri Sadeq Ali , Ali Kamran
Published: July 2024

Introduction The primary aim of undergraduate dental education is to prepare dental students for independent dental practice and to enable them to provide safe and effective dental care. This study aimed to investigate the self-perceived preparedness of senior dental undergraduate students in Turkey. Methods Purposive sampling was used to recruit final-year dental students from 10 dental institutions offering undergraduate dental programs in Turkey. Student preparedness was assessed using a previously validated dental preparedness assessment scale based on 50 items encompassing core clinical skills, cognitive attributes, and behavioral skills. The research instrument was then translated into Turkish. The R statistical environment for Windows was used for the data analysis. Results Responses were provided by 272 students (156 women and 116 men; 57% and 43%, respectively) across 10 different universities. The mean score of the participants was 75.68 with slightly higher scores for men compared to women (77.35 vs. 74.46 respectively). However, independent t-tests showed that the scores did not differ significantly between women and men. Conclusions This study evaluated the self-perceived preparedness for dental practice of final-year students from 10 universities in Turkey. Although the results showed several areas of weakness, the scores of self-perceived preparedness of Turkish students were comparable to those reported in Europe and Asia. These findings can be used to inform future curriculum development to support students in consolidating their learning in perceived areas of weakness.
Scoping review and evidence mapping of interventions aimed at improving reproducible and replicable science: Protocol
Authors: Dudda Leonie A. , Kozula Magdalena , Ross-Hellauer Tony , Kormann Eva , Spijker René , DeVito Nicholas , Gopalakrishna Gowri , Van den Eynden Veerle , Onghena Patrick , Naudet Florian , Banzi Rita , Fratelli Maddalena , Varga Monika , Gelsleichter Yuri Andrei , Stegeman Inge , Leeflang Mariska M.
Published: July 2024

Background Many interventions, especially those linked to open science, have been proposed to improve reproducibility in science. To what extent these propositions are based on scientific evidence from empirical evaluations is not clear. Aims The primary objective is to identify Open Science interventions that have been formally investigated regarding their influence on reproducibility and replicability. A secondary objective is to list any facilitators or barriers reported and to identify gaps in the evidence. Methods We will search broadly by using electronic bibliographic databases, broad internet search, and contacting experts in the field of reproducibility, replicability, and open science. Any study investigating interventions for their influence on the reproducibility and replicability of research will be selected, including those studies additionally investigating drivers and barriers to the implementation and effectiveness of interventions. Studies will first be selected by title and abstract (if available) and then by reading the full text by at least two independent reviewers. We will analyze existing scientific evidence using scoping review and evidence gap mapping methodologies. Results The results will be presented in interactive evidence maps, summarized in a narrative synthesis, and serve as input for subsequent research. Review registration This protocol has been pre-registered on OSF under doi https://doi.org/10.17605/OSF.IO/D65YS
Machine Learning Inspired Nanowire Classification Method based on Nanowire Array Scanning Electron Microscope Images
Authors: Brugnolotto Enrico , Aleksandrov Preslav , Sousa Marilyne , Georgiev Vihar
Published: July 2024

Background This article introduces an innovative classification methodology to identify nanowires within scanning electron microscope images. Methods Our approach employs advanced image manipulation techniques in conjunction with machine learning-based recognition algorithms. The effectiveness of our proposed method is demonstrated through its application to the categorization of scanning electron microscopy images depicting nanowires arrays. Results The method’s capability to isolate and distinguish individual nanowires within an array is the primary factor in the observed accuracy. The foundational data set for model training comprises scanning electron microscopy images featuring 240 III-V nanowire arrays grown with metal organic chemical vapor deposition on silicon substrates. Each of these arrays consists of 66 nanowires. The results underscore the model’s proficiency in discerning distinct wire configurations and detecting parasitic crystals. Our approach yields an average F1 score of 0.91, indicating high precision and recall. Conclusions Such a high level of performance and accuracy of ML methods demonstrate the viability of our technique not only for academic but also for practical commercial implementation and usage.