bluuebunny/crossref_metadata_2025 huggingface dataset:
Pathways to Consumers’ Minds: Using Machine Learning and Multiple EEG Metrics to Increase Preference Prediction Above and Beyond Traditional Measurements
Authors: Hakim Adam , Klorfeld Shira , Sela Tal , Friedman Doron , Shabat-Simon Maytal , Levy Dino J
Published: May 2018

A basic aim of marketing research is to predict consumers’ preferences and the success of marketing campaigns in the general population. However, traditional behavioral measurements have various limitations, calling for novel measurements to improve predictive power. In this study, we use neural signals measured with electroencephalography (EEG) in order to overcome these limitations. We record the EEG signals of subjects, as they watched commercials of six food products. We introduce a novel approach in which instead of using one type of EEG measure, we combine several measures, and use state-of-the-art machine learning algorithms to predict subjects’ individual future preferences over the products and the commercials’ population success, as measured by their YouTube metrics. As a benchmark, we acquired measurements of the commercials’ effectiveness using a standard questionnaire commonly used in marketing research. We reached 68.5% accuracy in predicting between the most and least preferred items and a lower than chance RMSE score for predicting the rank order preferences of all six products. We also predicted the commercials’ population success better than chance. Most importantly, we demonstrate for the first time, that for all of our predictions, the EEG measurements increased the prediction power of the questionnaires. Our analyses methods and results show great promise for utilizing EEG measures by managers, marketing practitioners, and researchers, as a valuable tool for predicting subjects’ preferences and marketing campaigns’ success.
Glioblastoma recurrence and the role of MGMT promoter methylation
Authors: Storey Katie , Leder Kevin , Hawkins-Daarud Andrea , Swanson Kristin , Ahmed Atique U. , Rockne Russell C. , Foo Jasmine
Published: May 2018

Tumor recurrence in glioblastoma multiforme (GBM) is often attributed to acquired resistance to the standard chemotherapeutic agent temozolomide (TMZ). Promoter methylation of the DNA repair gene MGMT has been associated with sensitivity to TMZ, while increased expression of MGMT has been associated with TMZ resistance. Clinical studies have observed a downward shift in MGMT methylation percentage from primary to recurrent stage tumors. However, the evolutionary processes driving this shift, and more generally the emergence and growth of TMZ-resistant tumor subpopulations, are still poorly understood. Here we develop a mathematical model, parameterized using clinical and experimental data, to investigate the role of MGMT methylation in TMZ resistance during the standard treatment regimen for GBM (surgery, chemotherapy and radiation). We first find that the observed downward shift in MGMT promoter methylation status between detection and recurrence cannot be explained solely by evolutionary selection. Next, our model suggests that TMZ has an inhibitory effect on maintenance methylation of MGMT after cell division. Finally, incorporating this inhibitory effect, we study the optimal number of TMZ doses per adjuvant cycle for GBM patients with high and low levels of MGMT methylation at diagnosis.
Min-Redundancy and Max-Relevance Multi-view Feature Selection for Predicting Ovarian Cancer Survival using Multi-omics Data
Authors: EL-Manzalawy Yasser , Hsieh Tsung-Yu , Shivakumar Manu , Kim Dokyoon , Honavar Vasant
Published: May 2018

Background

Large-scale collaborative precision medicine initiatives (e.g., The Cancer Genome Atlas (TCGA)) are yielding rich multi-omics data. Integrative analyses of the resulting multi-omics data, such as somatic mutation, copy number alteration (CNA), DNA methylation, miRNA, gene expression, and protein expression, offer the tantalizing possibilities of realizing the potential of precision medicine in cancer prevention, diagnosis, and treatment by substantially improving our understanding of underlying mechanisms as well as the discovery of novel biomarkers for different types of cancers. However, such analyses present a number of challenges, including the heterogeneity of data types, and the extreme high-dimensionality of omics data.

Methods

In this study, we propose a novel framework for integrating multi-omics data based on multi-view feature selection, an emerging research problem in machine learning research. We also present a novel multi-view feature selection algorithm, MRMR-mv, which adapts the well-known Min-Redundancy and Maximum-Relevance (MRMR) single-view feature selection algorithm for the multi-view settings.

Results

We report results of experiments on the task of building a predictive model of cancer survival from an ovarian cancer multi-omics dataset derived from the TCGA database. Our results suggest that multi-view models for predicting ovarian cancer survival outperform both view-specific models (i.e., models trained and tested using one multi-omics data source) and models based on two baseline data fusion methods.

Conclusions

Our results demonstrate the potential of multi-view feature selection in integrative analyses and predictive modeling from multi-omics data.
Actin cytoskeleton self-organization in single epithelial cells and fibroblasts under isotropic confinement
Authors: Jalal Salma , Huang Ruby Yun-Ju , Viasnoff Virgile , Tee Yee Han , Bershadsky Alexander
Published: May 2018

We systematically investigated the principles of actin cytoskeleton self-organization in two cell types, fibroblasts and epitheliocytes, by confining isolated cells on isotropic adhesive islands of varying size. In fibroblasts, we previously described that an initially circular pattern of circumferential actin dynamically evolves into a radial pattern of actin bundles that spontaneously transforms into a chiral pattern, before finally producing parallel linear stress fibres. We now show that progression from circular to chiral actin patterns depends on cell projected area and rarely occurs on small islands. Epitheliocytes however, did not exhibit succession through all the actin patterns described above even on large islands. Upon confinement, the actin cytoskeleton in non-keratinocyte epitheliocytes is arrested at the circular stage, while in keratinocytes it can progress as far as the radial pattern but still cannot break symmetry. Epithelial-mesenchymal transition pushed actin cytoskeleton development from circular towards radial patterns but remains insufficient to cause chirality. Surprisingly, small doses of G-actin sequestering drug, latrunculin A, induced chiral swirling in keratinocytes. During this swirling, keratin filaments follow actin and also demonstrate chiral swirling movement. Elimination of the keratin network by genetic silencing of Type II keratins, however, did not affect the self-organization of the actin cytoskeleton.
Family-Based Haplotype Estimation and Allele Dosage Correction for Polyploids Using Short Sequence Reads
Authors: Motazedi Ehsan , Finkers Richard , Maliepaard Chris , de Ridder Dick
Published: May 2018

DNA sequence reads contain information about the genomic variants located on a single chromosome. By extracting and extending this information (using the overlaps of the reads), the haplotypes of an individual can be obtained. Adding parent-offspring relationships to the read information in a population can considerably improve the quality of the haplotypes obtained from short reads, as pedigree information can compensate for spurious overlaps (due to sequencing errors) and insufficient overlaps (due to shallow coverage). This improvement is especially beneficial for polyploid organisms, which have more than two copies of each chromosome and are therefore more difficult to be haplotyped compared to diploids. We develop a novel method, PopPoly, to estimate polyploid haplotypes in an F1-population from short sequence data by considering the transmission of the haplotypes from the parents to the offspring. In addition, PopPoly employs this information to improve genotype dosage estimation and to call missing genotypes in the population. Through realistic simulations, we compare PopPoly to other haplotyping methods and show its better performance in terms of phasing accuracy and the accuracy of phased genotypes. We apply PopPoly to estimate the parental and offspring haplotypes for a tetraploid potato cross with 10 offspring, using Illumina HiSeq sequence data of 9 genomic regions involved in plant maturity and tuberisation.
A guide to using a multiple-matrix animal model to disentangle genetic and nongenetic causes of phenotypic variance
Authors: Thomson Caroline E. , Winney Isabel S. , Salles Oceane C. , Pujol Benoit
Published: May 2018

Non-genetic influences on phenotypic traits can affect our interpretation of genetic variance and the evolutionary potential of populations to respond to selection, with consequences for our ability to predict the outcomes of selection. Long-term population surveys and experiments have shown that quantitative genetic estimates are influenced by nongenetic effects, including shared environmental effects, epigenetic effects, and social interactions. Recent developments to the “animal model” of quantitative genetics can now allow us to calculate precise individual-based measures of non-genetic phenotypic variance. These models can be applied to a much broader range of contexts and data types than used previously, with the potential to greatly expand our understanding of nongenetic effects on evolutionary potential. Here, we provide the first practical guide for researchers interested in distinguishing between genetic and nongenetic causes of phenotypic variation in the animal model. The methods use matrices describing individual similarity in nongenetic effects, analogous to the additive genetic relatedness matrix. In a simulation of various phenotypic traits, accounting for environmental, epigenetic, or cultural resemblance between individuals reduced estimates of additive genetic variance, changing the interpretation of evolutionary potential. These variances were estimable for both direct and parental nongenetic variances. Our tutorial outlines an easy way to account for these effects in both wild and experimental populations. These models have the potential to add to our understanding of the effects of genetic and nongenetic effects on evolutionary potential. This should be of interest both to those studying heritability, and those who wish to understand nongenetic variance.
Cargo Transport Shapes the Spatial Organization of a Microbial Community
Authors: Shrivastava Abhishek , Patel Visha K. , Tang Yisha , Yost Susan Connolly , Dewhirst Floyd E. , Berg Howard C.
Published: May 2018

The human microbiome is an assemblage of diverse bacteria that interact with one another to form communities. Bacteria in a given community are arranged in a three-dimensional matrix with many degrees of freedom. Snapshots of the community display well-defined structures, but the steps required for their assembly are not understood. Here, we show that this construction is carried out with the help of gliding bacteria. Gliding is defined as the motion of cells over a solid or semi-solid surface without the necessity of growth or the aid of pili or flagella. Genomic analysis suggests that gliding bacteria are present in human microbial communities. We focus on Capnocytophaga gingivalis which is present in abundance in the human oral microbiome. Tracking of fluorescently-labeled single cells and of gas bubbles carried by fluid flow shows that swarms of C. gingivalis are layered, with cells in the upper layers moving more rapidly than those in the lower layers. Thus, cells also glide on top of one another. Cells of non-motile bacterial species attach to the surface of C. gingivalis and are propelled as cargo. The cargo cell moves along the length of a C. gingivalis cell, looping from one pole to the other. Multi-color fluorescent spectral imaging of cells of different live but non-motile bacterial species reveals their long-range transport in a polymicrobial community. A swarm of C. gingivalis transports some non-motile bacterial species more efficiently than others and helps shape the spatial organization of a polymicrobial community.

Significance

We describe a situation in which bacteria typical of the human oral microbiome are organized spatially by gliding cells, species of Capnocytophaga, that move backwards and forwards over the substratum. The mobile adhesins that pull the cells over the substratum also attach to cells of non-motile bacterial species, which are carried up and down the motile cells as cargo. The synchronized transport of non-motile cargo bacteria helps shape a polymicrobial community.
Soft drinks and monogenetic diabetes: a study on the Wolfram syndrome 1 (Wfs1) deficient mouse model
Authors: Porosk Rando , Pintšuk Julia , Punapart Marite , Soomets Ursel , Terasmaa Anton , Kilk Kalle
Published: May 2018

In a modern society, the risk of developing type II diabetes and obesity may be linked to the increased consumption of carbohydrate-rich drinks. Several genes, including Wolfram Syndrome 1 (WFS1), have been reported to increase susceptibility for developing type II diabetes. In this study we aimed to investigate the effect of chronic consumption of carbohydrate-rich drinks on weight gain, overall consumption of liquids, glucose tolerance and liver metabolism in Wfs1-deficient mice. Wfs1-deficient and wild-type mice were divided into three groups that consumed regular Coca-Cola, 20% sucrose solution or water ad libitum as the only source of liquid. During the experiment, daily liquid consumption was determined. After 30 days, total weight gain of mice was calculated and glucose tolerance test was performed. The liver tissue was analysed by means of untargeted and targeted metabolomics using liquid chromatography-mass spectrometry. Weight gain was strongly affected by mouse genotype (p<0.001), their drink (p<0.001) and the interaction of both genotype and drink (p<0.001). Coca-Cola significantly increased liquid consumption in knock-out mice. There was an effect of the drink (p<0.001) and the interaction between the genotype and treatment (p=0.02) on blood glucose level while Coca-Cola and 20% sucrose solution exacerbated glucose intolerance in the knock-out mice. In untargeted metabolic profiling, the water consuming wild-type and heterozygous mice were found to be the most distinctive from the mice with all other genotype and drink combinations. Targeted analysis revealed interactions between the genotype and drink regarding to glycolysis and lipogenesis. In the wild-type animals, carbohydrate overload was alleviated by converting glucose to lipids. However, the same mechanism is not implemented in knock-out animals, as lipolysis and gluconeogenesis are upregulated by Wfs1 deficiency. In conclusion, our study demonstrates a significant interaction between the genotype and the drink when comparing wild-type and Wfs1 knock-out mice consuming soft drinks.
Testing soil nematode extraction efficiency using different variations of the Baermann funnel method
Authors: Schulz Annika Eva , Eisenhauer Nico , Cesarz Simone
Published: May 2018

Nematodes are increasingly used as powerful bioindicators of soil food web composition and functioning in ecological studies. Todays’ ecological research aims to investigate not only local relationships but global patterns, which requires consistent methodology across locales. Thus, a common and easy extraction protocol of soil nematodes is needed. In this study, we present a detailed protocol of the Baermann funnel method and highlight how different soil pre-treatments and equipment (soil type, amount of soil, sieving, filter type) can affect extraction efficiency and community composition by using natural nematode communities. We found that highest nematode extraction efficiency was achieved using lowest soil weight (25 g instead of 50 g or 100 g) in combination with soil sieving, and by using milk filters (instead of paper towels). PCA at the family level revealed that different pre-treatments significantly affected nematode community composition. Increasing the amount of soil increased the proportion of larger-sized nematodes being able to overcome long distances. Sieving is suggested to break up soil aggregates and, therefore, facilitate moving in general. Interestingly, sieving did not negatively affect larger nematodes that are supposed to have a higher probability of getting bruised during sieving. The present study shows that variations in the extraction protocol can alter the total density and community composition of extracted nematodes and provides recommendations for an efficient and standardized approach in future studies. Having a simple, cheap, and standardized extraction protocol can facilitate the assessment of soil biodiversity in global contexts.
Small-angle neutron scattering measurements of δ-phase deuteride (hydride) precipitates in Zircaloy 4
Authors: Heuser Brent J. , Lin Jun-Li , Do Changwoo , He Lilin
Published: May 2018

Small-angle neutron scattering (SANS) measurements have been performed under ambient conditions to characterize deuteride (hydride) particles in Zircaloy 4, a fuel cladding material used in pressurized light-water nuclear reactors. Hydrogen pickup by the cladding leads to a rim structure in which large circumferential hydride plate-like particles preferentially form on the cooler water-side region of the cladding. Deuterium substitution has been used to increase the coherent response and decrease the incoherent background of the SANS measurements. Four bulk deuterium concentrations were investigated, approximately 100, 400, 500 and 1000 parts per million by weight (w.p.p.m.) deuterium, as well as a zero-deuterium-concentration reference sample. The net SANS response from the deuteride phase was determined at all concentration values after subtraction of the reference SANS response, which effectively subtracted the strong scattering from second-phase particles in as-received Zircaloy. The net SANS response consisted of strong Porod scattering from deuteride particles over the entire measured Q range (0.005–0.4 Å−1). The net SANS response was anisotropic at concentrations greater than 100 w.p.p.m. and required elliptical averaging analysis. A significant sample orientation effect on the intensity of the SANS response was observed, due to preferential alignment of deuteride particles. The effect of ex situ applied stress at elevated temperature on deuteride phase dissolution and reprecipitation was investigated; a weak effect was observed with SANS that could not be confirmed by optical microscopy.
X-ray diffractometer for the investigation of temperature- and magnetic field-induced structural phase transitions
Authors: Faske Tom , Donner Wolfgang
Published: May 2018

This article reports the development and characterization of a laboratory-based high-resolution X-ray powder diffractometer equipped with a 5.5 T magnet and closed-cycle helium cryostat that is primarily designed for the investigation of magneto-structural phase transitions. Unique features of the diffractometer include the position-sensitive detector, allowing the collection of an entire diffraction pattern at once, and the high energy resolution with Mo Kα1radiation. The ability to utilize a lower energy resolution but higher photon flux by switching to an X-ray mirror monochromator makes it a versatile setup for a variety of compounds. In this contribution, details of the design and performance of the instrument are presented along with its specifications.
Development of a conceptual framework on real options theory for strategic human resource management
Authors: Bhattacharyya Som Sekhar
Published: May 2018

Purpose

The purpose of this paper is to propose a conceptual real options theory framework for the firms to use options to mitigate both investment risks and retention of the trained human resources.

Design/methodology/approach

This conceptual paper is built with logical argumentation.

Findings

The growth of IT firms has created a demand for quality IT industry employees in substantive quantity in India. IT firms provide training and development (T&D) inputs for developing better skills of employees for better employee and superior firm performance. T&D input requires firm investment. It also creates enhanced market demand for the trained employee. High growth area like IT firms not only competes for market but also for employees. A trained employee might leave the firm that provided the training to join a rival firm which offers relatively better salary, a catch -22 situation. This paper develops a real options-based framework for strategic human resource management (HRM).

Research limitations/implications

This work integrates the theory of real options and strategic HRM.

Originality/value

This conceptual work is one of the first attempts to use real options theory on strategic HRM.
Housing demand in Indian metros: a hedonic approach
Authors: Roy Debarpita
Published: May 2018

Purpose

This paper aims to understand housing demand of urban Indian households in terms of housing and household-level characteristics. Because a house is a bundle of certain characteristics which vary across houses, each characteristic has an implicit price. Finding this implicit price for certain important characteristics is the first objective of this study. The second objective of the paper is to compute the income elasticity and price elasticity of housing demand for these cities.

Design/methodology/approach

To achieve comparable estimates, household-level data from India’s National Sample Survey Organisation housing surveys for the years 2002 and 2008-2009 have been used. A hedonic price function is estimated using ordinary least squares (OLS) and Box-Cox functional forms to estimate the implicit prices of housing characteristics. This exercise is attempted for owned and rented houses separately. Demand function required for computing the elasticities, uses the hedonic price index derived from the implicit prices and household characteristics.

Findings

The study finds housing demand to be income elastic and price inelastic for the six cities across both the time periods.

Originality/value

Firstly, this study includes housing characteristics such as individual access to drinking water, modern sanitation facility, separate kitchen, condition of the structure, existence of a road with street light and whether the house is in a slum or non-slum area in the hedonic price function. These variables were not used in any of the earlier studies pertaining to India. Secondly, it uses the Box-Cox non-linear form to derive the hedonic price function, a specification not used earlier. Thirdly, this is the first study analysing housing demand across the six largest Indian cities.
Leveraging supply chain collaboration in pursuing radical innovation
Authors: Yunus Erlinda N.
Published: May 2018

Purpose

The purpose of this study is to examine the relationship between supply chain collaboration and innovation. It particularly investigates the effect of collaboration on radical innovation and highlights the positive impact of innovation, both radical and incremental, on business performance.

Design/methodology/approach

A survey of 230 Indonesian firms was conducted and the instrument was tested for reliability and validity to warrant its psychometric properties. The data were analyzed using structural equation modeling.

Findings

This study reveals that collaboration with suppliers brings radical innovation, while collaboration with customers brings incremental innovation. Contrary to this study’s conjecture, albeit interesting, collaboration with customers negatively affects radical innovation. Both radical and incremental innovations further exert a positive influence over firm performance.

Research limitations/implications

This study focuses on the relationships between supply chain collaboration, innovation and firm performance. The results enhance our understanding of types of innovation that are promoted by each dimension of collaboration. Further studies could extend the research by using a more elaborate measure of innovation or perform a longitudinal examination.

Practical implications

Managers are encouraged to pursue innovation as it improves firm performance. They could exploit their current partnership with customers to generate incremental innovation or leverage their supplier network to develop radical innovation.

Originality/value

Studies that specifically investigate the impact of firms’ collaboration with their supply chain partners on radical innovation are quite scarce. This empirical study is among the very few to fill this void by providing an integrative assessment of customer, supplier and internal collaborations and their impact on both radical and incremental innovation.
Africa-China investment and growth link
Authors: Koomson-Abekah Isaac , Nwaba Eugene Chinweokwu
Published: May 2018

Purpose

This paper aims to investigate China–Africa Investment link, using over two decades of FDI’s data. During the specified periods, African economic growth path has been predominantly upward trending, despite multiple external threats. This impressive growth was partly because of the growth of FDI stock across the region. This study explores the various sources of FDI to Africa, mainly China’s FDI’s and how they influence African macroeconomic indicators, i.e. unemployment, export and import activities.

Design/methodology/approach

Pesaran autoregressive distributive lag (ARDL) is used as a framework to test the short-run and long-run relationship of indicators. Granger causality test checked the causality between growth and macroeconomic indicators.

Findings

The link between China’s FDI and African economic growth reported a negative/declining effect in both short and long run. In the long run, the effect of world FDI on growth was significant but not the in the short run. However, US FDI to Africa, China Export and Import from Africa reported an insignificant effect on growth. There was no evidence of Okun’s law, as a decrease in Africa unemployment does not increase growth. Overall, China’s FDI’s inflows to Africa are allocated to capital-intensive activities which has less labor employability. The Granger causality test reported a uni-directional link between growth and all series, except for human capital which experienced no link at all in all directions. Despite the issue of socio-infrastructure militating against growth in the region, African economy is likely to perform better, if more FDI’s are channeled into labor-intensive activities, because it has a reductive effect on unemployment.

Research limitations/implications

The research considered point annual FDI data but not accumulated stock and is a macro-based study, i.e. regional economy.

Practical implications

This paper bridged the literature gap in African investment performance by providing an empirical justification in understanding the inflow of FDI, especially China. This is a useful guard in policy design and implementations in the attraction of the right type of investment, so as to reduce unemployment and promote growth.

Originality/value

The authors confirm that this study has not been published elsewhere and is not under consideration in whole or in part by another journal.
Community participation in the management of palm leaf manuscripts as Lanna cultural material in Thailand
Authors: Jarusawat Piyapat , Cox Andrew , Bates Jo
Published: May 2018

Purpose

The cultural heritage of the Lanna region of upper Northern Thailand is unique. One of its distinctive features is palm leaf manuscripts (PLMs), which are viewed simultaneously as examples of sacred writing and religious symbols, means of transferring cultural knowledge, artefacts of beauty and fragile historical documents. Local people still care about these objects, and speak the language but knowledge of the script is limited. The purpose of this paper is to explore the views of community members and experts about the value and management of PLMs as the basis for developing a model of community-based collection management.

Design/methodology/approach

Because the purpose was to explore differing perceptions and beliefs around PLMs the study adopted an interpretivist worldview. Data were collected through interviews with local people with an interest in PLMs and experts who advised on organising them. In addition, observation and a photo inventory method was used to collect data. Data were analysed thematically.

Findings

The results showed that while both groups saw the value of the knowledge PLMs contained, the community placed particular importance on the earning of “merit” through activities related to them as Buddhist objects. Experts gave particular emphasis to the knowledge of herbal medicine contained in the PLMs. The community valued indigenous storage and preservation practices. Experts were particularly pre-occupied with the intellectual property issue around medical knowledge and convenient storage and digitisation.

Research limitations/implications

Existing theory around libraries, archives and museums suggest some starting points for how community participation might be managed, but the unique circumstances of Lanna PLMs calls for a distinctive approach.

Practical implications

The paper identifies a pathway suitable to the Lanna context that can build on current local practices, to enhance community participation in the management of PLMs, including a consideration of the role of information professionals.

Originality/value

This paper is one of the first to extend thinking about participatory practices in the library, archive and museum literature to the context of Thailand and specifically to the case of PLMs, in the Lanna region. Rigorous data analysis of a substantial body of evidence has enhanced the understanding of the different types of value placed on PLMs. It identifies an important but not unbridgeable tension between how local people and experts view PLMs. It builds on previous library, archive and museum theory to propose a realistic model of how communities and experts (including librarians) can work together to protect the rich cultural resource represented by PLMs.
Festival community networks and transformative place-making
Authors: Jarman David
Published: May 2018

Purpose

Festivals are often explicitly connected to the destinations in which they take place, explored here as contributing to broader processes of place-making and engagement with local communities. Place is defined at a local scale, primarily as experienced by volunteer contributors to an arts and cultural festival in urban Scotland. Networked relationships between festival volunteers inform the research methods and analysis, reflecting both observer and insider perspectives. This paper aims to comment on varying attitudes among the contributors, relating these findings to their positions in the festival’s social network.

Design/methodology/approach

Social network analysis methods were used to capture and examine data from a sample of festival volunteers: a survey instrument was distributed among individuals identified by the creative director, acting as a key informant. These data generated information on connections between the respondents, as well as demographic and opinion-based attribute data. Network centrality measures were used to sample the respondents for four follow-up interviews with festival volunteers.

Findings

The resulting network revealed a core-periphery structure to the festival’s organising team. The influential core group members were more established volunteers, recognised for their value to the team. The festival was widely endorsed as contributing to local place-making, though not uncritically. Management implications were identified for the dual nature of the festival organisation: a formal hierarchy with clear functional departments, acting as a platform for an intangible yet vital social network.

Originality/value

Social relationships are shown to have profound implications for the management and identity of this volunteer festival, in relation to its host neighbourhood. Combining social network analysis with semi-structured interviews has demonstrated the value of this mixed methods approach.
Succeeding in an increasingly Agile world
Authors: Denning Steve
Published: May 2018

Purpose

As Agile management thinking spreads to every part and every kind of organization, including their competitors, corporate leaders need to take steps to ensure they get and keep a good seat at the Agile table.

Design/methodology/approach

The author’s first hand research finds that firms are learning the hard way that software process and value innovation requires a different way of running the organization to be successful. The whole firm has to become nimble, adaptable and able to adjust on the fly to meet the shifting whims of a marketplace driven by dynamic changes in customer value.

Findings

The Agile way of working is provoking a revolution in business that affects almost everyone. Agile organizations are connecting everyone and everything, everywhere, all the time. They are capable of delivering instant, intimate, frictionless value on a large scale.

Practical implications

Examples of the new way of running organizations are everywhere apparent. It’s not just the five biggest firms by market capitalization: Amazon, Apple, Facebook, Google and Microsoft. It’s also firms like Airbnb, Etsy, Lyft, Menlo Innovations, Netflix, Saab, Samsung, Spotify, Tesla, Uber and Warby Parker.

Social implications

A new kind of management was needed to enable this new kind of worker -- a fundamentally different way of running organizations. Agile is economically more productive and a better fit with the new marketplace. And it had immense potential benefit for the human spirit. It could create workplaces that enabled human beings to contribute their full talents on something worthwhile and meaningful – creating value for other human beings.

Originality/value

Continuing the management practices and structures of the lumbering industrial giants of the 20th Century is no longer a viable option for today’s firms. To survive, let alone thrive, leaders today must recognize that Agile is not something happening in software alone.
Juvenile survival, competing risks, and spatial variation in mortality risk of a marine apex predator
Authors: Benson John F. , Jorgensen Salvador J. , O'Sullivan John B. , Winkler Chuck , White Connor F. , Garcia‐Rodriguez Emiliano , Sosa‐Nishizaki Oscar , Lowe Christopher G.
Published: May 2018

Reliable estimates of mortality have been a major gap in our understanding of population ecology for marine animals. This is especially true for juveniles, which are often the most vulnerable age class and whose survival can strongly influence population growth. Thousands of pop‐up archival satellite tags (PAT) have been deployed on a variety of marine species, but analysis of these data has mainly been restricted to movement ecology and post‐handling survival following fisheries bycatch. We used PAT data to provide empirical estimates of annual survival and cause‐specific mortality for juveniles of a marine top predator.

We tagged and tracked juvenile white sharks in the north eastern Pacific Ocean to (1) estimate survival rates and competing risks and (2) investigate intrinsic and environmental influences on mortality risk. We also evaluated the use of PAT data with respect to meeting assumptions of known‐fate survival models.

Annual juvenile survival rate was 0.632 (SE = 0.15) and annual natural mortality rate (0.08, SE = 0.06) was lower than the rate of gillnet interactions (0.48, SE = 0.15). Mortality risk decreased with greater body length and was significantly greater (hazard ratio = 9.05, SE = 0.70) for juvenile sharks in Mexican waters, relative to California waters.

The PAT data allowed for unambiguous determination of fate in most cases, aided by collaborative relationships with fishers and secondary tags deployed on a subset of sharks. Although caution must be exercised to establish whether assumptions are met, our work demonstrates that PAT data represent a widely available, untapped data source that could dramatically increase our understanding of marine population ecology.

Synthesis and applications. Our research shows fisheries bycatch to be the main source of mortality for juvenile white sharks in the northeastern Pacific Ocean, highlighting the need for best practices, such as releasing sharks quickly following incidental capture. Furthermore, mortality risk for juveniles was greater in Mexican waters, such that survival may be lower in colder years when juveniles are likely to move south seeking warmer water. This could increase stochasticity in juvenile survival and negatively influence population growth for this apex predator.
The politics of ageing: health consumers, markets and hegemonic challenge
Authors: Salter Brian , Salter Charlotte
Published: May 2018

In recent years ageing has travelled from the placid backwaters of politics into the mainstream of economic, social and cultural debate. What are the forces that have politicised ageing, creating a sustained opposition to the supply side hegemony of pharmaceuticals, medicine and state which has historically constructed, propagated and legitimised the understanding of ageing as decline in social worth? In addressing this question, the paper develops Gramsci's theory of hegemony to include the potentially disruptive demand side power of consumers and markets. It shows how in the case of ageing individuals acting in concert through the mechanisms of the market, and not institutionalised modes of opposition, may become the agents of hegemonic challenge through a combination of lifecourse choice and electoral leverage. In response, the hegemony is adapting through the promotion of professionally defined interpretations of ‘active ageing’ designed to retain hegemonic control. With the forces of hegemony and counter‐hegemony nicely balanced and fresh issues such as intergenerational justice constantly emerging, the political tensions of ageing are set to continue.
‘Scarier than another storm’: values at risk in the mapping and insuring of US floodplains
Authors: Elliott Rebecca
Published: May 2018

How do people respond to the ways in which insurance mediates environmental risks? Socio‐cultural risk research has characterized and analyzed the experiential dimension of risk, but has yet to focus on insurance, which is a key institution shaping how people understand and relate to risk. Insurance not only assesses and communicates risk; it also economizes it, making the problem on the ground not just one of risk, but also of value. This article addresses these issues with an investigation of the social life of the flood insurance rate map, the central technology of the U.S. National Flood Insurance Program (NFIP), as it grafts a new landscape of ‘value at risk’ onto the physical and social world of New York City in the aftermath of Hurricane Sandy. Like other risk technologies, ubiquitous in modern societies as decision‐making and planning tools, the map disseminates information about value and risk in order to tame uncertainty and enable prudent action oriented toward the future. However, drawing together interview, ethnographic, and documentary data, I find that for its users on the ground, the map does not simply measure ‘value at risk’ in ways that produce clear strategies for protecting property values from flooding. Instead, it puts values‐beyond simply the financial worth of places‐at risk, as well as implicates past, present, and future risks beyond simply flooding. By informing and enlarging the stakes of what needs protecting, and from what, I argue that plural and interacting ‘values at risk’ shape how people live with and respond to environmental risks that are mediated by insurance technologies.
The Impact of the Hospital Readmissions Reduction Program across Insurance Types in California
Authors: Zingmond David S. , Liang Li‐Jung , Parikh Punam , Escarce José J.
Published: May 2018

Objective

Examine 30‐day readmission rates for indicator conditions before and after adoption of the Hospital Readmissions Reduction Program (HRRP).

Data

California hospital discharge data, 2005 to 2014.

Study Design

Estimated difference between pre‐HRRP trends and post‐HRRP rates of hospital readmissions after hospitalization for indicator conditions targeted by the HRRP (heart attack, heart failure, and pneumonia) by payer among insured adults.

Principal Findings

Post‐HRRP, reductions occurred for the three conditions among Fee‐for‐Service (FFS) Medicare. Readmissions decreased for heart attack and heart failure in Medicare Managed Care (MC). No reductions were observed in the younger commercially insured.

Conclusions

Post‐HRRP, greater than expected reductions occurred in rehospitalizations for patients with Medicare FFS and Medicare MC. HRRP incentives may be influencing system‐wide changes influencing care outside of traditional Medicare.
Preparedness for treating victims of terrorist attacks in Australia: Learning from recent military experience
Authors: Rosenfeld Jeffrey V , Mitra Biswadev , Smit De Villiers , Fitzgerald Mark C , Butson Benjamin , Stephenson Michael , Reade Michael C
Published: May 2018

The Australian health system is generally well prepared for mass casualty events. Fortunately, there have been very few terrorist attacks and these have involved low numbers of casualties compared with events overseas. Nevertheless, Australian health professionals need to be prepared to treat mass casualties with blast and ballistic trauma. The US military and its allies including Australia have had extensive experience with mass casualty management in the Middle East and Afghanistan wars for more than a decade. To define their experience, they developed the Tactical Combat Casualty Care Guidelines that have saved many lives. It is now prudent to incorporate this knowledge and experience into civilian practice in Australia.
Stability of potential renal acid load
Authors: Versele Vickà , Clarys Peter , Deforche Benedicte , Lefevre Johan , Mertens Evelien , Charlier Ruben , Knaeps Sara , Aerenhouts Dirk
Published: May 2018

Aim

The potential renal acid load (PRAL) has been described in relation to different health outcomes. Outcomes over time and conclusions made are often based on baseline dietary intake values. However, to study reliable long‐term associations, parameters calculated based on dietary intake data, such as PRAL, must be stable over time. Therefore, the aim of the present study was to assess the stability of PRAL and its components over a 10‐year time period.

Methods

PRAL values of three‐day dietary intake data from 197 women and 373 men on two assessment moments (2002–2004 and 2012–2014) were calculated. Pearson correlation and intra‐class correlation coefficients were used for assessing the stability of PRAL and its components. Level of agreement between the two assessment moments was estimated after splitting up subjects in quintiles of PRAL, calculating kappa values and changes of quintiles over time.

Results

No significant differences in mean PRAL over time were found. Stability of PRAL and its components was low. Poor agreement between the first and second assessment was shown by low kappa values and change of most of the subjects to an adjacent and non‐adjacent quintile after 10 years.

Conclusions

Based on nutrition assessments carried out using three‐day dietary records, stability of PRAL over a 10‐year time period could not be confirmed, even though no significant difference between mean PRAL and its components over time was found. Therefore, interpretation of longitudinal outcomes based on PRAL and its component calculated at baseline should be interpreted with caution.
EGFR exon 20 insertion mutation in advanced thymic squamous cell carcinoma: Response to apatinib and clinical outcomes
Authors: Yudong Su , Zhaoting Meng , Xinyue Wang , Li Lin , Xiaoyan Xu , Ran Zuo , Jinliang Chen , Peng Chen
Published: May 2018

Thymic carcinoma (TC) is a rare malignant tumor of the mediastinum with occult onset, rapid development, and poor prognosis. Surgery is the main treatment for early TC, but the majority of patients are diagnosed at Masaoka‐Koga stage III or IV with local invasion or distant metastasis. Platinum and anthracyclines are currently considered key components of first‐line chemotherapy for advanced TC; however, there are no standard treatment plans for patients who are refractory to first‐line and further chemotherapy. The clinical effect is also unsatisfactory. Apatinib has been successfully applied as third‐line treatment for advanced gastric cancer and has shown high efficacy in the treatment of various cancers, such as lung, liver, and colorectal cancers. Herein we report a case of advanced thymic squamous cell carcinoma harboring EGFR exon 20 insertion in which apatinib was administered after multi‐line chemotherapy and radiotherapy and a partial response was achieved after five months of treatment. To date, a five month overall response and 10 months of progression‐free survival have been achieved. Adverse reactions can be controlled and the patient's quality of life has improved. Apatinib provides a new option for clinicians to treat patients with advanced TC.
Antagonizing peroxisome proliferator‐activated receptor γ facilitates M1‐to‐M2 shift of microglia by enhancing autophagy via the LKB1–AMPK signaling pathway
Authors: Ji Juan , Xue Teng‐Fei , Guo Xu‐Dong , Yang Jin , Guo Ruo‐Bing , Wang Juan , Huang Ji‐Ye , Zhao Xiao‐Jie , Sun Xiu‐Lan
Published: May 2018

Microglia‐mediated neuroinflammation plays a dual role in various brain diseases due to distinct microglial phenotypes, including deleterious M1 and neuroprotective M2. There is growing evidence that the peroxisome proliferator‐activated receptor γ (PPARγ) agonist rosiglitazone prevents lipopolysaccharide (LPS)‐induced microglial activation. Here, we observed that antagonizing PPARγ promoted LPS‐stimulated changes in polarization from the M1 to the M2 phenotype in primary microglia. PPARγ antagonist T0070907 increased the expression of M2 markers, including CD206, IL‐4, IGF‐1, TGF‐β1, TGF‐β2, TGF‐β3, G‐CSF, and GM‐CSF, and reduced the expression of M1 markers, such as CD86, Cox‐2, iNOS, IL‐1β, IL‐6, TNF‐α, IFN‐γ, and CCL2, thereby inhibiting NFκB–IKKβ activation. Moreover, antagonizing PPARγ promoted microglial autophagy, as indicated by the downregulation of P62 and the upregulation of Beclin1, Atg5, and LC3‐II/LC3‐I, thereby enhancing the formation of autophagosomes and their degradation by lysosomes in microglia. Furthermore, we found that an increase in LKB1–STRAD–MO25 complex formation enhances autophagy. The LKB1 inhibitor radicicol or knocking down LKB1 prevented autophagy improvement and the M1‐to‐M2 phenotype shift by T0070907. Simultaneously, we found that knocking down PPARγ in BV2 microglial cells also activated LKB1–AMPK signaling and inhibited NFκB–IKKβ activation, which are similar to the effects of antagonizing PPARγ. Taken together, our findings demonstrate that antagonizing PPARγ promotes the M1‐to‐M2 phenotypic shift in LPS‐induced microglia, which might be due to improved autophagy via the activation of the LKB1–AMPK signaling pathway.