COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study
Authors:   ISARIC Clinical Characterisation Group, Abdukahil Sheryl Ann , Abe Ryuzo , Abel Laurent , Absil Lara , Acker Andrew , Adachi Shingo , Adam Elisabeth , Adrião Diana , Ainscough Kate , Hssain Ali Ait , Tamlihat Younes Ait , Akimoto Takako , Al-Dabbous Tala , Al-Fares Abdulrahman , Al Qasim Eman , Alalqam Razi , Alex Beatrice , Alexandre Kévin , Alfoudri Huda , Alidjnou Kazali Enagnon , Aliudin Jeffrey , Allavena Clotilde , Allou Nathalie , Alves João , Alves Rita , Amaral Maria , Ammerlaan Heidi , Ampaw Phoebe , Andini Roberto , Andrejak Claire , Angheben Andrea , Angoulvant François , Ansart Séverine , Antonelli Massimo , De Brito Carlos Alexandre Antunes , Arabi Yaseen , Aragao Irene , Arcadipane Antonio , Arenz Lukas , Arlet Jean-Benoît , Arnold-Day Christel , Arora Lovkesh , Artaud-Macari Elise , Asensio Angel , Assie Jean Baptiste , Atique Anika , Auchabie Johann , Aumaitre Hugues , Azemar Laurène , Azoulay Cécile , Bach Benjamin , Bachelet Delphine , Baillie J. Kenneth , Bak Erica , Bakakos Agamemnon , Banisadr Firouzé , Barbalho Renata , Barclay Wendy S. , Barnikel Michaela , Barrelet Audrey , Barrigoto Cleide , Basmaci Romain , Rincon Diego Fernando Bautista , Bedossa Alexandra , Behilill Sylvie , Beljantsev Aleksandr , Bellemare David , Beltrame Anna , Beluze Marine , Benech Nicolas , Benkerrou Dehbia , Bennett Suzanne , Bento LuÍs , Berdal Jan-Erik , Bergeaud Delphine , Bertolino Lorenzo , Bessis Simon , Bevilcaqua Sybille , Bhavsar Krishna , Humaid Felwa Bin , Bissuel François , Biston Patrick , Bitker Laurent , Blanco-Schweizer Pablo , Blot Mathieu , Boccia Filomena , Bogaert Debby , Bompart François , Booth Gareth , Borges Diogo , Borie Raphaël , Bos Jeannet , Bosse Hans Martin , Botelho-Nevers Elisabeth , Bouadma Lila , Bouchaud Olivier , Bouchez Sabelline , Bouhmani Dounia , Bouhour Damien , Bouiller Kévin , Bouillet Laurence , Bouisse Camille , Boureau Anne-Sophie , Bouscambert Maude , Bouziotis Jason , Boxma Bianca , Boyer-Besseyre Marielle , Boylan Maria , Braga Cynthia , Brandenburger Timo , Brazzi Luca , Breen Dorothy , Breen Patrick , Brickell Kathy , Brozzi Nicolas , Buchtele Nina , Buesaquillo Christian , Bugaeva Polina , Buisson Marielle , Burhan Erlina , Bustos Ingrid G. , Butnaru Denis , Cárcel Sheila , Cabie André , Cabral Susana , Caceres Eder , Callahan Mia , Calligy Kate , Calvache Jose Andres , Camões João , Campana Valentine , Campbell Paul , Canepa Cecilia , Cantero Mireia , Caraux-Paz Pauline , Cardoso Filipa , Cardoso Filipe , Cardoso Sofia , Carelli Simone , Carlier Nicolas , Carney Gayle , Carpenter Chloe , Carret Marie-Christine , Carrier François Martin , Carson Gail , Casanova Maire-Laure , Cascão Mariana , Casimiro José , Cassandra Bailey , Castañeda Silvia , Castanheira Nidyanara , Castor-Alexandre Guylaine , Castrillón Henry , Castro Ivo , Catarino Ana , Catherine François-Xavier , Cavalin Roberta , Cavalli Giulio Giovanni , Cavayas Alexandros , Ceccato Adrian , Cervantes-Gonzalez Minerva , Chair Anissa , Chakveatze Catherine , Chan Adrienne , Chand Meera , Chas Julie , Chassin Camille , Chen Anjellica , Chen Yih-Sharng , Cheng Matthew Pellan , Cheret Antoine , Chiarabini Thibault , Chica Julian , Chirouze Catherine , Chiumello Davide , Cho Hwa Jin , Cho Sung Min , Cholley Bernard , Cidade Jose Pedro , Herreros Jose Miguel Cisneros , Citarella Barbara Wanjiru , Ciullo Anna , Clarke Jennifer , Clohisey Sara , Codan Cassidy , Cody Caitriona , Coelho Alexandra , Colin Gwenhaël , Collins Michael , Colombo Sebastiano Maria , Combs Pamela , Connelly J. P. , Connor Marie , Conrad Anne , Contreras Sofía , Cooke Graham S. , Copland Mary , Cordel Hugues , Corley Amanda , Cormican Sarah , Cornelis Sabine , Corpuz Arianne Joy , Corvaisier Grégory , Couffignal Camille , Couffin-Cadiergues Sandrine , Courtois Roxane , D’Orleans Charles Crepy , Croonen Sabine , Crowl Gloria , Crump Jonathan , Cruz Claudina , Csete Marc , Cucino Alberto , Cullen Caroline , Cummings Matthew , Curley Gerard , Curlier Elodie , Custodio Paula , D’Aragon Frédérick , Da Silva Filipe Ana , Da Silveira Charlene , D’Ortenzio Eric , Dabaliz Al-Awwab , Dagens Andrew B. , Dalton Heidi , Dalton Jo , Daneman Nick , Dankwa Emmanuelle A. , Dantas Jorge , De Castro Nathalie , De Mendoza Diego , De Oliveira França Rafael Freitas , De Rosa Rosanna , De Silva Thushan , De Vries Peter , Dean David , Debray Marie-Pierre , Dechert William , Deconninck Lauren , Decours Romain , Delacroix Isabelle , Delavigne Karen , Deligiannis Ionna , Dell’amore Andrea , Delobel Pierre , Demonchy Elisa , Denis Emmanuelle , Deplanque Dominique , Depuydt Pieter , Desai Mehul , Descamps Diane , Desvallée Mathilde , Dewayanti Santi Rahayu , Diallo Alpha , Diamantis Sylvain , Dias André , Diaz Juan Jose Diaz , Diaz Rodrigo , Didier Kévin , Diehl Jean-Luc , Dieperink Wim , Dimet Jérôme , Dinot Vincent , Diouf Alphonsine , Dishon Yael , Djossou Félix , Docherty Annemarie B. , Dong Andy , Donnelly Christl A. , Donnelly Maria , Donohue Chloe , Dorival Céline , Douglas James Joshua , Douma Renee , Dournon Nathalie , Downer Triona , Downing Mark , Drake Tom , Dubee Vincent , Dubos François , Ducancelle Alexandra , Dudman Susanne , Dunning Jake , Mangoni Emanuele Durante , Duranti Silvia , Durham Lucian , Dussol Bertrand , Duval Xavier , Dyrhol-Riise Anne Margarita , Eira Carla , Vidal José Ernesto , Sanharawi Mohammed El , Elapavaluru Subbarao , Elharrar Brigitte , Elkheir Natalie , Ellerbroek Jacobien , Ellis Rachael , Eloy Philippine , Elshazly Tarek , Enderle Isabelle , Engelmann Ilka , Enouf Vincent , Epaulard Olivier , Esperatti Mariano , Esperou Hélène , Esposito-Farese Marina , Estevão João , Etienne Manuel , Etienne Manuel , Ettalhaoui Nadia , Everding Anna Greti , Evers Mirjam , Fabre Isabelle , Faheem Amna , Fahy Arabella , Fairfield Cameron J. , Faria Pedro , Farshait Nataly , Fatoni Arie Zainul , Faure Karine , Fayed Mohamed , Feely Niamh , Fernandes Jorge , Fernandes Marília , Fernandes Susana , Ferrão Joana , Devouge Eglantine Ferrand , Ferraz Mário , Ferreira Benigno , Ferrer-Roca Ricard , Figueiredo-Mello Claudia , Flateau Clara , Fletcher Tom , Florio Letizia Lucia , Foley Claire , Fomin Victor , Fonseca Claudio Duarte , Fonseca Tatiana , Fontela Patricia , Forsyth Simon , Foti Giuseppe , Fourn Erwan , Fowler Rob , Franch-Llasat Diego , Fraser Christophe , Fraser John , Freire Marcela Vieira , Ribeiro Ana Freitas , Friedrich Caren , Fry Stéphane , Fuentes Nora , Fukuda Masahiro , Gómez-Junyent Joan , Gaborieau Valérie , Gachet Benoît , Gaci Rostane , Gagliardi Massimo , Gagnard Jean-Charles , Gagneux-Brunon Amandine , Gaião Sérgio , Gallagher Phil , Curto Elena Gallego , Gamble Carrol , Garan Arthur , Garcia-Gallo Esteban , Garcia Rebekha , Garot Denis , Garrait Valérie , Gault Nathalie , Gavin Aisling , Gaymard Alexandre , Gebauer Johannes , Morlaes Louis Gerbaud , Germano Nuno , Ghosn Jade , Giani Marco , Giaquinto Carlo , Gibson Jess , Gigante Tristan , Gilg Morgane , Giordano Guillermo , Girvan Michelle , Gissot Valérie , Giwangkancana Gezy , Glikman Daniel , Glybochko Petr , Gnall Eric , Goco Geraldine , Goehringer François , Goepel Siri , Goffard Jean-Christophe , Golob Jonathan , Gorenne Isabelle , Goujard Cécile , Goulenok Tiphaine , Grable Margarite , Grandin Edward Wilson , Granier Pascal , Grasselli Giacomo , Green Christopher A. , Greenhalf William , Greffe Segolène , Grieco Domenico Luca , Griffee Matthew , Griffiths Fiona , Grigoras Ioana , Groenendijk Albert , Lordemann Anja Grosse , Gruner Heidi , Gu Yusing , Guedj Jérémie , Guellec Dewi , Guerguerian Anne-Marie , Guerreiro Daniela , Guery Romain , Guillaumot Anne , Guilleminault Laurent , Guimard Thomas , Haber Daniel , Hakak Sheeba , Hall Matthew , Halpin Sophie , Hamer Ansley , Hamidfar Rebecca , Hammond Terese , Hardwick Hayley , Harley Kristen , Harrison Ewen M. , Harrison Janet , Hays Leanne , Heerman Jan , Heggelund Lars , Hendry Ross , Hennessy Martina , Henriquez-Trujillo Aquiles , Hentzien Maxime , Hernandez-Montfort Jaime , Hidayah Astarini , Higgins Dawn , Higgins Eibhilin , Hinton Samuel , Hipólito-Reis Ana , Hiraiwa Hiroaki , Hiscox Julian A. , Ho Antonia Ying Wai , Hoctin Alexandre , Hoffmann Isabelle , Hoiting Oscar , Holt Rebecca , Holter Jan Cato , Horby Peter , Horcajada Juan Pablo , Hoshino Koji , Hoshino Kota , Hough Catherine L. , Hsu Jimmy Ming-Yang , Hulot Jean-Sébastien , Ijaz Samreen , Illes Hajnal-Gabriela , Inácio Hugo , Dominguez Carmen Infante , Iosifidis Elias , Irvine Lacey , Isgett Sarah , Isidoro Tiago , Isnard Margaux , Itai Junji , Ivulich Daniel , Jaafoura Salma , Jabot Julien , Jackson Clare , Jamieson Nina , Jaureguiberry Stéphane , Javidfar Jeffrey , Jean-Benoît Zabbe , Jego Florence , Jenum Synne , Sotomayor Ruth Jimbo , GarcÍa Ruth Noemí Jorge , Joseph Cédric , Joseph Mark , Jouvet Philippe , Jung Hanna , Kafif Ouifiya , Kaguelidou Florentia , Kali Sabina , Kalomoiri Smaragdi , Kandamby Darshana Hewa , Kandel Chris , Kant Ravi , Kartsonaki Christiana , Kasugai Daisuke , Katz Kevin , Johal Simreen Kaur , Keating Sean , Kelly Andrea , Kelly Sadie , Kennedy Lisa , Kennon Kalynn , Kerroumi Younes , Kestelyn Evelyne , Khalid Imrana , Khalil Antoine , Khan Coralie , Khan Irfan , Kho Michelle E. , Khoo Saye , Kida Yuri , Kiiza Peter , Kildal Anders Benjamin , Kimmoun Antoine , Kindgen-Milles Detlef , Kitamura Nobuya , Klenerman Paul , Bekken Gry Kloumann , Knight Stephen , Kobbe Robin , Vasconcelos Malte Kohns , Korten Volkan , Kosgei Caroline , Krawczyk Karolina , Vecham Pavan Kumar , Kumar Deepali , Kurtzman Ethan , Kutsogiannis Demetrios , Kyriakoulis Konstantinos , L’her Erwan , Lachatre Marie , Lacoste Marie , Laffey John G. , Lagrange Marie , Laine Fabrice , Lambert Marc , Lamontagne François , Langelot-Richard Marie , Lantang Eka Yudha , Lanza Marina , Laouénan Cédric , Laribi Samira , Lariviere Delphine , Launay Odile , Lavie-Badie Yoan , Law Andrew , Le Bihan Clément , Le Bris Cyril , Le Coustumier Eve , Le Falher Georges , Le Gac Sylvie , Le Hingrat Quentin , Le Maréchal Marion , Le Mestre Soizic , Le Moing Vincent , Le Nagard Hervé , Le Turnier Paul , León Rafael , Le Minh , Santos Marta Leal , Leal Ema , Lee James , Lee Su Hwan , Lee Todd , Leeming Gary , Lefebvre Bénédicte , Lefebvre Laurent , Lefevre Benjamin , Lellouche François , Lemaignen Adrien , Lemee Véronique , Lemmink Gretchen , Leone Michela , Lepiller Quentin , Lescure François-Xavier , Lesens Olivier , Lesouhaitier Mathieu , Levy-Marchal Claire , Levy Bruno , Levy Yves , Bassi Gianluigi Li , Liang Janet , Lim Wei Shen , Lina Bruno , Lind Andreas , Lingas Guillaume , Lion-Daolio Sylvie , Liu Keibun , Loforte Antonio , Lolong Navy , Lopes Diogo , Lopez-Colon Dalia , Loubet Paul , Lucet Jean Christophe , Luna Carlos M. , Lungu Olguta , Luong Liem , Luton Dominique , Lyons Ruth , Müller Fredrik , Müller Karl Erik , Maasikas Olavi , Macdonald Sarah , Machado Moïse , Macheda Gabrielle , Sanchez Juan Macias , Madhok Jai , Mahieu Rafael , Mahy Sophie , Maier Lars Siegfrid , Maillet Mylène , Maitre Thomas , Malfertheiner Maximilian , Malik Nadia , Maltez Fernando , Malvy Denis , Mambert Marina , Manda Victoria , Mandei Jose M. , Manning Edmund , Manuel Aldric , Sant Ceila Maria , Malaque Ana , Marino Flávio , De Araújo Mariz Carolline , Eid Charbel Maroun , Marques Ana , Marquis Catherine , Marsh Brian , Marsh Laura , Marshall John , Martelli Celina Turchi , Martin-Blondel Guillaume , Martin-Loeches Ignacio , Martin-Quiros Alejandro , Martin Dori-Ann , Martin Emily , Martinot Martin , Rego Caroline Martins , Martins Ana , Martins João , Martucci Gennaro , Marwali Eva Miranda , Jimenez Juan Fernado Masa , Maslove David , Mason Sabina , Matan Moshe , Mathieu Daniel , Mattei Mathieu , Matulevics Romans , Maulin Laurence , Mc Evoy Natalie , McCarthy Aine , McCloskey Colin , McConnochie Rachael , McDermott Sherry , McDonald Sarah , McElwee Samuel , McEvoy Natalie , McGeer Allison , McGuinness Niki , McLean Kenneth A. , McNicholas Bairbre , Meaney Edel , Mear-Passard Cécile , Mechlin Maggie , Mele Ferruccio , Menon Kusum , Mentré France , Mentzer Alexander J. , Mercier Noémie , Merckx Antoine , Mergler Blake , Merson Laura , Mesquita António , Meybeck Agnès , Meynert Alison M. , Meyssonnier Vanina , Meziane Amina , Mezidi Medhi , Michelanglei Céline , Mihnovitš Vladislav , Maldonado Hugo Miranda , Mone Mary , Moin Asma , Molina David , Molinos Elena , Monteiro Agostinho , Montes Claudia , Montrucchio Giorgia , Moore Sarah , Moore Shona C. , Morales-Cely Lina , Moro Lucia , Tutillo Diego Rolando Morocho , Motos Ana , Mouquet Hugo , Perrot Clara Mouton , Moyet Julien , Mullaert Jimmy , Munblit Daniel , Murphy Derek , Murris Marlène , Myrodia Dimitra Melia , N’guyen Yohan , Neant Nadège , Neb Holger , Nekliudov Nikita A. , Neto Raul , Neumann Emily , Neves Bernardo , Ng Pauline Yeung , Ng Wing Yiu , Choileain Orna Ni , Nichol Alistair , Nonas Stephanie , Noret Marion , Norman Lisa , Notari Alessandra , Noursadeghi Mahdad , Nowicka Karolina , Nseir Saad , Nunez Jose I. , Nyamankolly Elsa , O’Donnell Max , O’Hearn Katie , O’Neil Conar , Occhipinti Giovanna , Ogston Tawnya , Ogura Takayuki , Oh Tak-Hyuk , Ohshimo Shinichiro , Oinam Budha Charan Singh , Oliveira Ana Pinho , Oliveira João , Olliaro Piero , Ong David S. Y. , Oosthuyzen Wilna , Openshaw Peter J. M. , Orozco-Chamorro Claudia Milena , Orquera Andrés , Osatnik Javier , Ouamara Nadia , Ouissa Rachida , Owyang Clark , Oziol Eric , Póvoas Diana , Pagadoy Maïder , Pages Justine , Palacios Mario , Palmarini Massimo , Panarello Giovanna , Panda Prasan Kumar , Panigada Mauro , Pansu Nathalie , Papadopoulos Aurélie , Parra Briseida , Pasquier Jérémie , Patauner Fabian , Patrão Luís , Paul Christelle , Paul Mical , Paulos Jorge , Paxton William A. , Payen Jean-François , Pearse India , Peek Giles J. , Peelman Florent , Peiffer-Smadja Nathan , Peigne Vincent , Pejkovska Mare , Peltan Ithan D. , Pereira Rui , Perez Daniel , Perpoint Thomas , Pesenti Antonio , Petroušová Lenka , Petrov-Sanchez Ventzislava , Peytavin Gilles , Pharand Scott , Piagnerelli Michael , Picard Walter , Picone Olivier , Piel-Julian Marie , Pierobon Carola , Pimentel Carlos , Piroth Lionel , Pius Riinu , Piva Simone , Plantier Laurent , Plotkin Daniel , Poissy Julien , Pokorska-Spiewak Maria , Poli Sergio , Pollakis Georgios , Popielska Jolanta , Postma Douwe F. , Povoa Pedro , Powis Jeff , Prapa Sofia , Prebensen Christian , Preiser Jean-Charles , Prestre Vincent , Price Nicholas , Prinssen Anton , Pritchard Mark G. , Proença Lúcia , Puéchal Oriane , Purcell Gregory , Quesada Luisa , Quist-Paulsen Else , Quraishi Mohammed , Rätsep Indrek , Rössler Bernhard , Rabaud Christian , Rafiq Marie , Ragazzo Gabrielle , Rainieri Fernando , Ramakrishnan Nagarajan , Ramanathan Kollengode , Rammaert Blandine , Rapp Christophe , Rasmin Menaldi , Rau Cornelius , Rebaudet Stanislas , Redl Sarah , Reeve Brenda , Reid Liadain , Reis Renato , Remppis Jonathan , Remy Martine , Renk Hanna , Resende Liliana , Resseguier Anne-Sophie , Revest Matthieu , Rewa Oleksa , Reyes Luis Felipe , Richardson David , Richardson Denise , Richier Laurent , Riera Jordi , Rios Ana Lúcia , Rishu Asgar , Rispal Patrick , Risso Karine , Nuñez Maria Angelica Rivera , Rizer Nicholas , Roberto André , Roberts Stephanie , Robertson David L. , Robineau Olivier , Roche-Campo Ferran , Rodari Paola , Rodeia Simão , Abreu Julia Rodriguez , Roilides Emmanuel , Rojek Amanda , Romaru Juliette , Roncon-Albuquerque Roberto , Roriz Mélanie , Rosa-Calatrava Manuel , Rose Michael , Rosenberger Dorothea , Rossanese Andrea , Rossignol Bénédicte , Rossignol Patrick , Roy Carine , Roze Benoît , Russell Clark D. , Ryckaert Steffi , Holten Aleksander Rygh , Choez Xavier Sánchez , Saba Isabela , Sadat Musharaf , Saidani Nadia , Salazar Leonardo , Sales Gabriele , Sallaberry Stéphane , Salvator Hélène , Sanchez-Miralles Angel , Sanchez Olivier , Sancho-Shimizu Vanessa , Sandhu Gyan , Sandulescu Oana , Santos Marlene , Sarfo-Mensah Shirley , Sarton Benjamine , Saviciute Egle , Savvidou Parthena , Scarsbrook Joshua , Schermer Tjard , Scherpereel Arnaud , Schneider Marion , Schroll Stephan , Schwameis Michael , Scott-Brown James , Scott Janet T. , Sedillot Nicholas , Seitz Tamara , Semaille Caroline , Semple Malcolm G. , Senneville Eric , Sequeira Filipa , Sequeira Tânia , Shadowitz Ellen , Shamsah Mohammad , Sharma Pratima , Shaw Catherine A. , Shaw Victoria , Shiban Nisreen , Shime Nobuaki , Shimizu Hiroaki , Shimizu Keiki , Shrapnel Sally , Shum Hoi Ping , Mohammed Nassima Si , Sigfrid Louise , Silva Catarina , Silva Maria Joao , Sin Wai Ching , Skogen Vegard , Smith Sue , Smood Benjamin , Smyth Michelle , Snacken Morgane , So Dominic , Solis Monserrat , Solomon Joshua , Solomon Tom , Somers Emily , Sommet Agnès , Song Myung Jin , Song Rima , Song Tae , Sonntagbauer Michael , Soum Edouard , Uva Maria Sousa , Sousa Marta , Souza-Dantas Vicente , Sperry Alexandra , Sriskandan Shiranee , Staudinger Thomas , Stecher Stephanie-Susanne , Stienstra Ymkje , Stiksrud Birgitte , Streinu-Cercel Adrian , Streinu-Cercel Anca , Strudwick Samantha , Stuart Ami , Stuart David , Sultana Asfia , Summers Charlotte , Svistunov Magdalena Surovcová Andrey A. , Syrigos Konstantinos , Sztajnbok Jaques , Szuldrzynski Konstanty , Téoulé François , Tabrizi Shirin , Tagherset Lysa , Talarek Ewa , Taleb Sara , Talsma Jelmer , Le Van Tan , Tanaka Hiroyuki , Tanaka Taku , Taniguchi Hayato , Tardivon Coralie , Tattevin Pierre , Taufik M. Azhari , Tedder Richard S. , Teixeira João , Tellier Marie-Capucine , Terpstra Pleun , Terrier Olivier , Terzi Nicolas , Tessier-Grenier Hubert , Thibault Vincent , Thiberville Simon-Djamel , Thill Benoît , Thompson A. A. Roger , Thompson Shaun , Thomson David , Thomson Emma C. , Thuy Duong Bich , Thwaites Ryan S. , Timashev Peter S. , Timsit Jean-François , Vijayaraghavan Bharath Kumar Tirupakuzhi , Toki Maria , Tonby Kristian , Santos-Olmo Rosario Maria Torres , Torres Antoni , Torres Margarida , Trioux Théo , Trieu Huynh Trung , Tromeur Cécile , Trontzas Ioannis , Troost Jonathan , Trouillon Tiffany , Tual Christelle , Tubiana Sarah , Tuite Helen , Turtle Lance C. W. , Twardowski Pawel , Uchiyama Makoto , Ullrich Roman , Uribe Alberto , Usman Asad , Val-Flores Luís , Van De Velde Stijn , Van Den Berge Marcel , Van Der Feltz Machteld , Van Der Vekens Nicky , Van Der Voort Peter , Van Der Werf Sylvie , Van Dyk Marlice , Van Gulik Laura , Van Hattem Jarne , Van Lelyveld Steven , Van Netten Carolien , Vanel Noémie , Vanoverschelde Henk , Vauchy Charline , Veislinger Aurélie , Velazco Jorge , Ventura Sara , Verbon Annelies , Vieira César , Villanueva Joy Ann , Villar Judit , Villeneuve Pierre-Marc , Villoldo Andrea , Van Vinh Chau Nguyen , Visseaux Benoit , Visser Hannah , Vuorinen Aapeli , Vuotto Fanny , Wang Chih-Hsien , Wei Jia , Weil Katharina , Wesselius Sanne , Wham Murray , Whelan Bryan , White Nicole , Wiedemann Aurélie , Wille Keith , Wils Evert-Jan , Xynogalas Ioannis , Suen Jacky Y. , Yacoub Sophie , Yamazaki Masaki , Yazdanpanah Yazdan , Yelnik Cécile , Yerkovich Stephanie , Yokoyama Toshiki , Yonis Hodane , Young Paul , Yuliarto Saptadi , Zabbe Marion , Zacharowski Kai , Zahran Maram , Zambon Maria , Zanella Alberto , Zawadka Konrad , Zayyad Hiba , Zoufaly Alexander , Zucman David 
Published: June 2021

Background

The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms.

Methods

International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms.

Results

‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country.

Interpretation

This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men.