bluuebunny/crossref_metadata_2025 huggingface dataset:
Acupuncture treatment of essential hypertension
Authors: Hou Zhihui , Jia Yuqi , Zhang Xuecheng , Wang Qi , Dong Yujiang , Zhu Yongzheng , Fan Cuihong , Zhao Huanjun , Zhang Chunxiao , Zhang Yongchen , Jia Hongling
Published: March 2023

Objective: To study the effect of acupuncture on clinical symptom score, blood pressure (BP), ABI and baPWV index in patients with mild to moderate essential hypertension.
Methods: The single-blind Randomized controlled trial included 90 patients with mild to moderate essential hypertension who were randomly divided into two acupuncture groups and a control group. The control group was treated with Western medicine, while the experimental group was treated with medicine and acupuncture at different acupoints, Acupuncture Group Ⅰ and Acupuncture Group Ⅱ. The treatment lasted for 12 weeks and the indexes were collected before and after treatment. The primary outcome measure was changes in blood pressure. The secondary outcome measures were ABI, baPWV and TCM symptom score. The safety evaluation index was the incidence of adverse events.
Results: Acupuncture Group Ⅰ, Acupuncture Group Ⅱ and Control group all had 30 patients finished the study. The results showed that there were significant differences in blood pressure, ABI, baPWV index and TCM symptom score in the group compared with before intervention (P < 0.05). Acupuncture Group Ⅰ is superior to Acupuncture Group Ⅱ in improving systolic blood pressure, baPWV level, TCM symptom score and total effective rate. There are significant differences between the two groups and control group in various indexes, and the above differences are statistically significant (P<0.05). No significant complications occurred in the acupuncture group, no patient dropped out.
Conclusions: The results show that acupuncture can effectively reduce blood pressure, improve clinical symptoms, and improve the level of arteriosclerosis index with high safety. More effective acupuncture points have been explored.
Combining a noble gas with radiotherapy: Glutamate receptor antagonist xenon acts as a radiosensitizer in glioblastoma
Authors: Büttner Thomas , Maerevoet Marielena K. E. , Giordano Frank A. , Veldwijk Marlon R. , Herskind Carsten , Ruder Arne M.
Published: March 2023

Background
Ionotropic glutamate receptors AMPAR and NMDAR modulate proliferation, invasion and radioresistance in glioblastoma (GB). Pharmacological targeting is difficult as many in vitro-effective agents are not suitable for in patient applications. We aimed to develop a method to test the well tolerated AMPAR- and NMDAR-antagonist xenon gas as radiosensitizer in GB.
Methods
We designed a diffusion-based system to perform the colony formation assay (CFA), the radiobiological gold standard, under xenon exposure. Stable and reproducible gas atmosphere was validated with oxygen and carbon dioxide as tracer gases. After checking for AMPAR and NMDAR expression via immunofluorescence staining we performed the CFA with the glioblastoma cell lines U87 and U251 as well as the non-glioblastoma derived cell line HeLa. Xenon was applied after irradiation and additionally tested in combination with NMDAR antagonist memantine.
Results
The gas exposure system proved compatible with the CFA and resulted in a stable atmosphere of 50% xenon. Glutamate receptor subunits were present in glioblastoma-derived and to a lesser extent in HeLa cells. Significant radiosensitization by xenon was shown in U251 and U87 at irradiation doses of 4–8 Gy and 2–8 Gy, respectively (p < .05). The effect was further enhanced by the addition of memantine, showing significant reduction in the surviving fraction already at 2 Gy for both glioblastoma cell lines (p < .05). Xenon did not increase the radiosensitivity of HeLa cells until a radiation dose of 8 Gy.
Conclusion
The developed system allows for testing of gaseous agents with CFA. As a proof of concept, we have, for the first time, unveiled radiosensitizing properties of xenon gas in glioblastoma.
Single-Cell Sequencing Analysis Reveals the Correlation between Obesity and Circadian Rhythm in Spermatogenesis and Its Microenvironment
Authors: Wang Wei , Zhang Wei , Chen Jinshan , Wang Shuang , Mu Changjiang , Xi Yujia , Guo Qiang , Wang Jingqi
Published: March 2023

Background
Male infertility has gradually increased morbidity during these years. Due to the lack in understanding of specific mechanism of male infertility, the patients could not receive efficient treatment for a long period. Obesity was universally thought to correlate with male infertility. However, the underlying pathway of obesity inducing male infertility is still uncertain. Previous studies indicated that obesity could impact circadian rhythm in multiple tissues. Therefore, it's worth exploring the correlation between obesity and circadian rhythm and their effect to male infertility.
Methods
Based on a single-cell RNA sequencing dataset containing 12 human testicular tissues, we divided the testicular cells into different clusters. According to Body Mass Index (BMI), the cells were divided into normal (18.5 ≤ BMI ≤ 24.9), little fat (25.0 ≤ BMI ≤ 29.9) and very fat (30.0 ≤ BMI ≤ 34.9) groups. hdWGCNA was used to construct co-expression modules of circadian rhythm-related genes. CRD_scores were constructed to describe circadian rhythm conditions based on the modules. Differentially expressed genes (DEGs) between two groups were identified using the R package "seurat". Enrichment analysis were performed to explore the function of DEGs using relevant R packages. Statistical analysis including comparison and correlation analysis were also conducted using R.
Results
Co-expression modules were found to all correlate with BMI. Furthermore, circadian rhythm showed a significant correlation with obesity in every cell clusters. In spermatogenesis, obesity could induce circadian rhythm disruption (CRD) in related cells. In Leydig cells, obesity could disturb androgen production by inducing CRD, which will lead to androgen level disruption and further impact reproduction function. Two hub genes (STAT3 and CEBPD) in the red co-expression module were found to play an important part in the process of obesity inducing CRD in Leydig cells. In macrophages, relationship between obesity and circadian rhythm was found to correlate with inflammation response and spermatogenesis.
Conclusions
We determined the correlation between obesity and circadian rhythm in testicular cells. It's found that obesity-related CRD in testis could lead to disrupted spermatogenesis and androgen level, inflammation, which will cause male reproductive dysfunction and infertility.
Efficacy of Plasmoquine for the Treatment of Plasmodium Vivax and Plasmodium Falciparum
Authors: Issa Mahadi Abdujabar
Published: March 2023

This study is a response to the challenge of malaria infections, which remain a major public health in South Africa. Reports of malarial outbreaks in the country have been predominant in KwaZulu-Natal, Mpumalanga, and Limpopo provinces. Currently, combination therapy referred to artemisinin-based combination treatments (ACTs) has been recommended both by the World Health Organization and the National Department of Health of South Africa. However, due to widespread reports of artemisinin resistance, other alternative treatment options were explored. The aim of the study was thus to establish the efficacy of plasmoquine as an alternative treatment option among malaria patients in Johannesburg, the economic capital of South Africa, found in the Gauteng Province. The study adopted a quantitative approach, and a purposive retrospective investigation was adopted. Patient data from 2018-2022 was analyzed to determine the incidence of malaria in the study location and the efficacy of treatment with plasmoquine. The results of this study, therefore, indicate that P. falciparum is still the main cause of malaria in the study area. A total of 322 patient files were included in the study, with P. falciparum determined to be the main cause of infection over the four-year data assessed. Furthermore, plasmoquine was determined to be effective in treating malaria among 298 of the study population, with only 24 (7.5%) experiencing the development of vomiting after the treatment course. The findings of the study offer government makes policymakers the opportunity to develop policies that enhance the re-introduction of plasmoquine to combat malaria in South Africa. Keywords: Artemisinin-based combination treatments; Artemisinin resistance, Malaria; Plasmoquine.
Epidemiological Characteristics of Frailty and Ageing: Case Study of Elderly Hospice Care Sites in Burundi
Authors: Kwizera Pierre
Published: March 2023

Frailty and ageing are bound together, and frailty is linked with reduced capacity and low ability to survive adverse health outcomes. While ageing is glowing globally, in Burundi, a lot has been done to protect and improving the lives of old people, however, multiple challenges persist and limit them from benefiting from their human rights. We, therefore, thought to assess for factors influencing their quality of life, and then to discuss about measures to be taken to ensure ageing in good health. A descriptive cross-sectional study was done in three hospice care sites in Burundi and 57 participants were interviewed using a questionnaire between 16 February and 28th March 2022. Data were analyzed using the Computer Software Statistical Product and Service Solutions (SPSS 20.0). The relationship was considered significant when the P-value was less than the level of significance (<0.05) at 95% confidence interval. The research found that social status is linked with physical frail (p=0.029), and marital status was associated with the apparition of physical signs of frailty (p=0.005); In addition, 47.32 % with the underlining condition were without medication, 90% attended to a clinic 2 times and plus while 28.07% were admitted, 50.87% complained about the limited access to medicine and medical care and 61.40% complained about the variety and the quality of food. These factors can impact ageing in good health, and we recommend that comprehensive support for elderly people be in place and future research compare home-based support and support from hospice care. Keywords: Access, Ageing, Frailty, Healthcare, Support.
Implementing a Community-Based Participatory Approach to Promote Health Facility Delivery among Women of Reproductive Age in Kanamai Area, Kilifi County
Authors: Manyiwa Johnson S.
Published: March 2023

Maternal utilization has been low over the years in Kenya. Approaches to establish safe motherhood through promotion of health facility have been equally fronted. This study applied certain aspects of community education approach encompassing group discussion and community dialogue to provide a clear insight of how the approach is a vital tool. Community based cross sectional study was conducted in Kanamai sub-location, Kilifi County to recruit 232 women selected by simple random sampling technique. The data were collected using pre-tested semi-structured questionnaires and the collected data was coded, entered, cleaned, and analysed using R for Windows (version 4.0.3). Sixty-nine percent (69%) of women advocated for the delivery at the designated health facilities. Independent factors that were found to influence health facility based delivery in this study were being employed (OR = 12.42, 95% CI: 6.25 - 24.70, p<0.0001), having given birth to 3-4 children, (OR = 2.56, 95% CI: 6.25 - 24.70, p=0.0062) and rating of both group discussion (OR = 0.15, 95% CI: 0.03 -0.66, p=0.0041) and community dialogue (OR = 0.21, 95% CI: 0.08 - 0.59, p=0.0013) to be low. Leading by the example set by the government of offering free maternal services, engaging the key stakeholders through approaches such as group discussion and community dialogue could go a long way in increasing delivery in the health facilities thus tremendously lowering mortality rate for both the baby and the mother which could otherwise occur when the mother doesn’t get services of a specialized personnel. Keywords: Advocacy, Delivery, Community Education Group Discussion, Community Dialogue.
Effect of Interpersonal Communication Training Program on Knowledge, Attitude, and Reinforcing/Support Skills of Anti-retroviral Therapy Providers in Gombe State Hospitals
Authors: A Suraj Abdulkarim
Published: March 2023

Evidence from the developed world suggests that healthcare practitioners with greater Interpersonal communication (IPC) skills have better health outcomes after IPC training. There is less evidence from developing nations. This study examined the impact of an IPC training program on the knowledge, attitude, and reinforcing/supporting skills of ART practitioners at public ART hospitals in Gombe state, Nigeria. The study used a quasi-experimental design with two groups and two stages, as well as a multi-stage sampling approach. The knowledge disposition, attitude, and reinforcing and supporting IPC skills of 120 ART practitioners from six randomly selected hospitals were assessed. Then three weeks later, a 2-day IPC training using a self-administered structured questionnaire was carried out. SPSS Software (v. 22) was used to perform descriptive and inferential analyses on the data. At baseline, the Chi-Square test indicated no association between the groups on any of the demographic factors. The pre-intervention mean knowledge score was significantly higher (p = 0.019) in the experimental group than in the control group, although there were no significant differences in attitude (p=0.32) or reinforcing and support skills (p=0.786). After the IPC skills training program, significant differences were noticed between the experimental and control groups in terms of knowledge (p=.000) and attitude (p=0.006), but not in terms of reinforcing and support skills (p=.119). Training in interpersonal communication skills influences the knowledge and attitude of ART health providers in Gombe State. As a result, in-service IPC training is suggested for ART Health Providers in the State. Keywords: Anti-retroviral therapy (ART), Interpersonal communication (IPC), Reinforcing and supporting skills.
Authority and Responsibilities of a Notary Regarding the Liquidation Process of a Limited Liability Company in the Republic of Indonesia
Authors: . Ruko , . Sulistyandari , Bintoro Rahadi
Published: March 2023

A notary is a public official who has duties and authorities related to making an authentic deed, in this case, the making of an act and the dissolution of a limited liability company. A limited liability company is a type of business entity consisting of shares. The establishment of a Limited Liability Company must meet the requirements specified in the laws and regulations. The Company's organs must exist within the Company, including the Company's organs, the General Meeting of Shareholders, the Board of Directors and the Board of Commissioners. Then regarding the dissolution of the company, the dissolution of the Company must be followed by liquidation. Meanwhile, liquidation is carried out by the liquidator or curator either based on the decision of the General Meeting of Shareholders or a court decision. This study aims to analyze the powers and responsibilities of a Notary concerning the liquidation process of a Limited Liability Company in Indonesia. The research method used is normative, using secondary data obtained from library research, including primary, secondary, and tertiary legal sources. The authority of a notary is to make a deed of the minutes of the first and second General Meeting of Shareholders and draw up a deed of dissolution of a limited liability company. The responsibilities of a notary in the liquidation of a limited liability company are regarding the responsibility for the deed he made and the civil, administrative, and criminal responsibilities. There are three processes. The first is the General Meeting Shareholders regarding the approval of the dissolution and the appointment of a liquidator. Second, namely the General Meeting of Shareholders agenda of approval of the liquidator’s report and the granting of release and discharge of the liquidator’s responsibilities. Finally, namely the making of a deed of dissolution of the company by a Notary.
Medical Sorting (TRIAGE): Implementation Problems and Legislative Ways to Overcome Them
Authors: Korobtsova Nataliia
Published: March 2023

The relevance of the topic chosen for research is due to the situation in which Ukraine and the entire civilized world found themselves, –  the war and the pandemic of the acute respiratory disease COVID-19, which is caused by the SARS-CoV-2 coronavirus. How it is possible to provide medical care to as many people as possible without violating the principles of reasonableness and fairness in its provision is a question that both medical professionals and legal scholars of all democratic countries of the world are trying to answer. And one of the ways to solve this problem is the use of medical triage (TRIAGE). The purpose of this article is to consider medical triage as one of the forced measures of providing medical aid in emergency conditions, when there is a lack of medicines, medical personnel, medical equipment, etc., with a large number of victims. With the help of an empirical research method, as well as methods of analysis, generalization and explanation, the author managed to consider the history and reasons for the emergence of medical triage, investigate and determine the prerequisites for its use, positive and negative features, the possibility and necessity of its use during pandemics and states of war. The author identified the problems that arise in the application of medical triage and proposed ways to overcome them, which is the result of this study.
Replacing the Persecution Condition for Refugeehood
Authors: Beaton Eilidh
Published: March 2023

In this article, earlier versions of which were presented at the IVR World Congress in 2019 and in graduate student workshops at the University of Pennsylvania, the author offers a critical look at the existing definition of a refugee in international law, in particular, in the 1951 Convention relating to the Status of Refugees. The Convention recognizes a well-founded fear of persecution for reasons of race, religion, nationality, membership in a particular social group or political opinion as a condition for a person to be granted refugee status. However, this leaves significant gaps in the protection of persons fleeing indiscriminate or generalized violence or harm, although such people today constitute a significant proportion of those forced to move from their country of nationality. The author emphasizes that within some regions and countries there are legal instruments capable of bridging these gaps (the 1969 Organization of African Unity Convention on the Specific Aspects of Refugee Problems in Africa, the 1984 Cartagena Declaration on Refugees, as well as temporary protection in the EU and the US), but the UN Convention continues to be deficient in this regard.

The author proposes to correct these shortcomings by applying the “needs-first” approach, which understands refugees as all displaced persons fleeing sufficiently serious threats. The author presents her own definition of a refugee as “any person with a well-founded fear that their fundamental human rights are urgently threatened; who would have no recourse to their home government, even if appropriate international assistance were available; and whose interests can only or best satisfied by means of refugee – that is, by means of protection from a political authority that is not their own, usually in the form of asylum within the territory of that country.”

The author acknowledges that her proposed “needs-first” approach is not without its drawbacks, and the main challenge in its implementation is to avoid becoming a purely humanitarian measure and to preserve the political identity of the individuals who are fleeing the threat to countries not of their nationality.
Suitability of drinking water quality in Chittagong Metropolitan City, Bangladesh: research on urban water bodies (UWBs) using multivariate analytic techniques
Authors: Molla Morshed Hossan , Chowdhury Mohammad Abu Taiyeb , Muhibbullah Md. , Ali Kazi Md. Barkat , Bhuiyan Md. Habibur Rahman , Das Suman , Morshed A.J.M. , Das Jewel , Islam Saiful
Published: March 2023

This is empirical research that focuses on the urban water ecosystems in the humid tropics of South Asia. The purpose of the study was to evaluate the quality of drinking water in the urban water bodies (UWBs) of Chittagong Metropolitan City (CMC), Bangladesh. The field data was centered on the analysis and depiction of twenty-three (23) water quality parameters, collected from twenty-one (21) spatial observation units. Analytic tools include suitability analysis, correlation matrix, principal component analysis (PCA), and cluster analysis (CA) as a means to an end. The data were analyzed using SPSS. The analysis reveals that drinking water quality in studied UWBs was inappropriate during the monsoon season. Parameters that crossed the extreme permissible concentration incorporate EC, BOD, COD, Turbidity, Nitrate, Total coliform, and Fecal coliform. The PCA extracted four factors (PC1–4) with an eigenvalue of 10.23, explaining 73.1% of the total variation in the dataset in cumulative terms. The CA recognized three (3) broad groups of the sampling stations. Group A represents nine cases, suffering the most from pollution concentration in CMC. Awareness building at all levels is advocated to improve clean water sources, increase service provision, and ensure public health safeguards.
Engagement Académico: un elemento clave en la educación virtual
Authors: Sarmiento Martínez Ana María , Moreno Acero Ivan Dario , Morón Castro Camilo
Published: March 2023

Este artículo tiene como objetivo principal, reflexionar teóricamente sobre el lugar que ocupa el engagement académico en los programas universitarios virtuales. En la actualidad este concepto se muestra en la relación que los estudiantes construyen con los docentes, directivos, a través de las asignaturas y demás aspectos del proceso educativo cruciales para garantizar su éxito académico y su fidelidad con la institución. Este texto surge a partir de la revisión bibliográfica sistemática de la investigación titulada: El engagement de los estudiantes de maestrías virtuales de una universidad en Latinoamérica. Una mirada desde la perspectiva del engagement académico, del consumidor y la comunicación estratégica. Cuenta con nueve compontes en los que se aborda el concepto de engagement, sus desarrollos y aplicaciones en el contexto laboral y comunicativo, hasta llegar al ámbito académico virtual. Asimismo, a la conclusión, en la que se expone la necesidad de integrar este concepto y práctica comunicativa como un mecanismo con el que las instituciones educativas pueden reconocer las necesidades de los estudiantes y así asegurar la calidad académica holística.
A Review of Nanostructures in Electrowetting-on-dielectric Systems: From Nanostructured Dielectric Layers to Nanofluids
Authors: Budlayan Marco L. , Patricio Jonathan N. , Arco Susan D. , Guerrero Raphael A.
Published: March 2023

The extensive interest in electrowetting-on-dielectric (EWOD) as a key in advancing
the efficiency and controllability of fluid-based microelectromechanical and actuator systems
has resulted in a deluge of technological research, especially in the area of microfluidics, liquid
lenses, and fluid-based lab-on-chips. More recently, the integration of nanostructures into
EWOD-driven devices has shown promising improvement in these devices’ performance, design,
and miniaturization. Due to the exceptional properties, availability, versatility, and tunability
of nanostructures, they are being utilized as components of EWOD systems for various applications.
Utilization ranges from fabricating nanodimensional dielectric layers to incorporating
nanoparticles in fluid droplets. With the current trend in improving the performance and functionality
of EWOD-driven devices at low voltage operations, it is timely to revisit the fundamental
principle of EWOD phenomena and how it is extended experimentally using nanostructures.
In this paper, we present the different nanostructures investigated as dielectric materials in various
EWOD experiments focusing on metal oxide and silicon nitride layers. Notes on the structure
of these dielectric layers are also presented. Furthermore, various EWOD experiments employing
nanofluid droplets are also described. This paper provides a clear picture of nanostructures’
diverse impact on the advancement of EWOD technology. The insights presented in this
paper may also serve as a guidepost for future exploration and development of the role of
nanostructures in EWOD-driven devices.
Recent Trends in Nanocarriers for the Management of Atopic Dermatitis
Authors: Kumar Pravin , Ashawat Mahendra Singh , Pandit Vinay , Singh Verma Chandra Pal , Ankalgi Amar Deep , Kumar Manish
Published: March 2023

Background:

Atopic dermatitis (AD) is a pruritic inflammatory skin condition with increasing
global prevalence, almost affecting 15% to 30% of children and 5% of adults. AD results due to a
complex interaction between the impaired skin barrier function, allergens, and immunological cells.
Topical corticosteroids or calcineurin inhibitors in the form of creams or ointments are the mainstay of
therapy, but they have low skin penetration and skin barrier repair efficiency.

Objective:

The above limitations of conventional dosage forms have motivated the development of
nanoformulations of drugs for improved penetration and deposition in the skin for better management of
AD.

Methods:

Databases, such as Pubmed, Elsevier, and Google Scholar, were reviewed for the investigations
or reviews published related to the title.

Results:

The present review discusses the advantages of nanoformulations for the management of AD.
Further, it also discusses the various types of topically investigated nanoformulations, i.e., polymeric
nanoparticles, inorganic nanoparticles, solid lipid nanoparticles, liposomes, ethosomes, transfersomes,
cubosomes, and nanoemulsion for the management of atopic dermatitis. In addition, it also discusses
advancements in nanoformulations, such as nanofibres, nanosponges, micelles, and nanoformulations
embedded textiles development for the management of AD.

Conclusion:

The nanoformulations of drugs can be a better alternative for the topical management of
AD with enhanced skin penetration and deposition of drugs with reduced systemic side effects and better
patient compliance.
Chemo-enzymatic Synthesis of Rivastigmine Intermediate by Locally
Isolated Soil Fungus Fusarium graminearum
Authors: Basingi Suneelkumar Muragesh M. , Matadh Siddesh
Published: March 2023

Background:

Biocatalytic reactions are known as a green technology, capable of delivering
highly stereo-, chemo- and regioselective transformations that usually reduce the number of steps in a
synthetic route

Objective:

This work describes a process for the production of a key chiral intermediate N-ethyl-Nmethyl-carbamic acid-3-(1S-hydroxy-ethyl)-phenyl ester converted into chiral alcohol which can be further converted into rivastigmine

Methods:

The fungi isolated from different soil samples by the soil dilution plate technique were screened
for their ability to convert the selected intermediate. The selected organism is further grown under fermentation for gram scale conversion.

Results:

Among the different fungi isolated Fusarium graminearum selected for further study for reaction
optimization and gram scale conversion of the ketone substrate

Conclusion:

The reaction under fermentative condition for 48 hours at 30°C, pH 6 with agitation speed of
200rpm found to be optimal condition for the overall bioreduction process of the ketone employed in the study.
A New, Ecological and Stability-indicating Method by HPLC for the
Quantification of Moxifloxacin in Tablets
Authors: da Silva Thaisa Alves Celedonio , da Silva Júnior João Roberto , Kogawa Ana Carolina
Published: March 2023

Introduction:

A new, ecological, and stability-indicating method by HPLC was developed for
the quantification of moxifloxacin in tablets. A C18 column at 33°C, purified water acidified with 0.2%
phosphoric acid and ethanol (74:26,v/v), flow rate at 1.0 mLmin-1
, injection volume of 5 µL, and detection at 290 nm was used.

Methods:

The method was linear (2-12 µgmL-1
), selective, accurate (100.86%), precise (RSD<2%), and
robust.

Results:

The retention time for moxifloxacin in tablets was approximately 4.4 minutes.

Conclusion:

To sum up, a method based on the principles of green analytical chemistry was successfully
developed and validated for the quantification of moxifloxacin in tablets
Outpatient Intravenous Remdesivir to Prevent Progression to
Severe COVID-19: An Observational Study from a Greek Hospital
Authors: Kintrilis Nikolaos , Galinos Iosif
Published: March 2023

Background:

Remdesivir, a viral RNA polymerase inhibitor, has been a powerful
weapon in the battle against the SARS-CoV-2 pandemic. Originally approved for use in
hospitalized patients, remdesivir improves clinical outcomes in patients with moderate to
severe coronavirus disease 2019 (COVID-19). After proving efficacious in hospitalized
patients, its use was approved in early disease for symptomatic, non-hospitalized patients
that present risk factors for progression to severe disease.

Objective:

To evaluate whether administration of the antiviral medication remdesivir at an
outpatient basis has an effect on hospital admissions of patients presenting with SARSCoV-
2 infection.

Methods:

We conducted an observational clinical trial involving 107 non-hospitalized
COVID-19 patients who attended the emergency department of a third-level greek hospital
seeking care for symptoms appearing within the previous 5 days and who had at least one
risk factor for progression to severe disease. After arterial blood gas evaluation, eligible
patients received intravenous remdesivir at a dose of 200 mg on day 1 and 100 mg on days
2 and 3. The efficacy endpoint was set as COVID-19-related hospitalization or death in the
next 14 days.

Results:

A total of 107 patients (57.0% men) participated in the study, 51 (47.7%) of them
fully vaccinated. Most prevalent were age ≥ 60 years old, cardiovascular/cerebrovascular
disease, immunosuppression or malignancy, obesity, diabetes mellitus, and chronic lung
disease. All patients enrolled completed the 3-day course, with a total of 3 out of 107 patients
(2.8%) eventually having a COVID-19-related hospitalization by day 14, while no
deaths were reported by day 14.

Conclusion:

Among non-hospitalized patients with at least one risk factor for progression
to severe COVID-19, a 3-day course of intravenous remdesivir yielded favourable results.
(p, q, t)L-th Type and (p, q, t)L-th Weak Type Based Some Growth Properties of Composite Entire and Meromorphic Functions on the Basis of Their Integer Translation
Authors: Biswas Tanmay , Biswas Chinmay
Published: March 2023

The main objective of this chapter is to investigate some results related to the
growth rates of the composition of integer translated entire and meromorphic functions
using (p, q, t)L-th type and (p, q, t)L-th weak type.
(p, q, t)L-th Order and (p, q, t)L-th Type Based Some Growth Rates of Integer Translated Composite Entire and Meromorphic Functions
Authors: Biswas Tanmay , Biswas Chinmay
Published: March 2023

In this chapter, we establish some new results depending on the comparative
growth properties of the composition of integer translated entire and meromorphic functions using (p, q, t)L-th order and (p, q, t)L-th type.
PERENCANAAN ANGKUTAN PEMADU MODA BANDARA BALI UTARA-KABUPATEN BULELENG
Authors: Burkani Walida Magfiroh , Afrianti Dessy Angga , Handayani Sabrina
Published: March 2023

Bandara Bali Utara merupakan salah satu simpul transportasi yang sedang direncanakan di Provinsi Bali. Bandara ini nantinya akan menjadi bandara penyangga untuk Bandara Ngurah Rai di Kabupaten Badung, selain itu Bandara Bali Utara akan menjadi solusi untuk permasalahan kepadatan di Bali Selatan dan juga menjadi pembangkit perekonomian Bali Utara. Namun hingga saat ini belum terdapat layanan angkutan di Kabupaten Buleleng yang dapat melayani potensi permintaan penumpang Bandara Bali Utara. Penelitian ini dilakukan untuk mengetahui seberapa besar permintaan potensial, konsep operasional, tarif angkutan, dan skenario implementasi operasional dari angkutan pemadu moda di Bandara Bali Utara. Dari hasil analisis yang telah dilakukan didapat jumlah potensial demand tahun dasar sebesar 4.541 orang/hari, berdasarkan lokasi potensial demand tersebut ditentukan satu rute rencana angkutan pemadu moda, yaitu Terminal Banyuasri-Bandara Bali Utara dengan jumlah armada yang akan beroperasi yaitu 28 bus sedang dengan headway sebesar 10 menit. Biaya operasional kendaraan diestimasikan mencapai Rp.335 per bus-km sehingga tarif rencana yang dibebankan kepada penumpang adalah Rp.27.000. Berdasarkan analisis potensial demand di Kabupaten Buleleng, maka ditentukan 4 titik halte, yaitu Halte Pantai Lovina, Terminal Seririt, Halte Celukan Bawang, dan Halte Gerokgak.
Kata Kunci : potensial demand, kinerja operasional, biaya operasional kendaraan, tarif, implementasi operasional.
PENERAPAN KAWASAN BERORIENTASI TRANSIT DI KAWASAN TRANSIT BLOK M, JAKARTA SELATAN
Authors: Gifarry Pradamas , Ari Ismu Rini Dwi , Firdausiyah Nailah
Published: March 2023

Blok M merupakan kawasan komersial yang terletak dekat pusat kota Jakarta. Guna lahan yang didominasi oleh perdagangan dan jasa, serta telah dilalui oleh moda angkutan umum seperti BRT dan MRT, membuat Blok M merupakan kawasan yang potensial untuk dikembangkan sebagai kawasan TOD. Hal ini juga tertuang di dalam RDTR DKI Jakarta dan Peraturan Gubernur DKI Jakarta No. 55/2020. Namun, masyarakat lebih memilih kendaraan pribadi untuk menuju Kawasan Blok M dan menyebabkan kemacetan. Kecepatan rata-rata di 2 jalan utama (Panglima Polim dan Iskandarsyah Raya) kurang dari 30 km/jam. Penelitian ini bertujuan untuk mengukur tingkat kesesuaian Kawasan TOD Blok M berdasarkan ITDP TOD Standard 3.0 dan Permen ATR No. 16/2017. Penelitian dilakukan berdasarkan empat aspek, yaitu campuran dan keragaman pemanfaatan ruang, perencanaan kawasan yang ramah, penunjang kehidupan kawasan TOD serta transit, yang masing-masing dibagi lagi ke dalam variabel-variabel dengan standardnya masing-masing. Hasil penelitian menunjukkan jika tingkat kesesuaian kawasan TOD Blok M adalah 52,4% untuk Blok 1, 42,8% untuk Blok 2 dan 66,6% untuk Blok 3. Aspek perencanaan kawasan yang ramah yang berhubungan dengan variabel jalur pejalan kaki dan pesepeda menjadi aspek dengan nilai terendah di seluruh blok. Sementara itu, aspek transit mendapatkan nilai tertinggi. Secara umum, Kawasan TOD Blok M membutuhkan pengembangan dari aspek koneksi titik transit dengan bangunan, infrastruktur pejalan kaki, infrastruktur kendaraan tidak bermotor serta intensitas bangunan yang akan dirumuskan dengan analytical hierarchy process (AHP).
Kata Kunci : Analytical Hierarchy Process, kawasan Blok M, kesesuaian kawasan TOD, transit-oriented development.
Bimetallic Nanoparticles – Expanding Grassroots in Medical Health Care through Enhanced Microbial Resistance
Authors: Bhatti Laxmi
Published: March 2023

Nanotechnology has spawned a slew of new research and application opportunities. Bimetallic nanoparticles offer certain advantages over monometallic nanoparticles in magnetic and optical properties which have utmost requirement in medicinal industry for therapeutics and drug delivery system. The advantage of using a green synthesis technique results in increased stability and enhancement of many physical and chemical characteristics. Green synthesis has the benefit of being able to replace existing physical and chemical processes. Different monometallic nanoparticles have already been tested. Researchers are working on even trimetallic nanoparticles in present scenario. In the present investigation research cum review article, we have randomly selected medicinal plants available in campus itself as lockdown conditions were prevalent all over the country.The bimetallic Cu-Zn nanoparticles were synthesized using mostly leaves as plant parts, from these selected plant materials.The Cu-Zn nanoparticles were confirmed by their synthesis, using visual color change along with UV visible spectroscopy techniques. The nanoparticles after confirmation were opted further for testing their efficacy against standard pathogens for plants viz Terminalia, Tecoma and Solanum nigrum.The results have been promising and significant giving zones bigger in size than 20 mm.The research is ongoing to reveal further the inherent potential of medicinal plants to act as alternative agents for antimicrobial potential.
Víctor Rico-Gray (1951-2021): un recorrido por la vida de un gran visionario en la ecología
Authors: Castillo Guevara Citlalli , Cuautle Mariana , Díaz-Castelazo Cecilia , Serio Silva Juan Carlos
Published: March 2023

Como homenaje y permanente recuerdo de quienes fuimos sus estudiantes, continuando su legado, en conmemoración de su aniversario luctuoso, el día 4 de abril.
Assertiveness Behavior and Organizational Climate Among Workers in a Multinational Company in Malaysia
Authors: TKM Thangal Thahira Bibi , Sham Rohana , Co Maricel
Published: March 2023

This study empirically analyses the relationship between the dimensions of assertiveness behavior with organizational Climate among workers in a multinational company in Malaysia. Hence, this study was conducted to determine the potential effects of assertiveness behavior on organizational Climate. A total of 57 respondents were chosen to participate in this study based on the quantitative approach. Two methods were used as part of the measurements, including The Rathus Assertiveness Schedule, which measures the assertiveness dimensions mentioned in this study. The questionnaire will then be used to measure the organizational Climate. Interestingly, the organizational climate level shared different results.
Community Participation in Sustainable Tourism: A case study in Balige, Indonesia
Authors: Ginting Nurlisa , Munazirah  , Wahid Julaihi
Published: March 2023

The current tourism industry always incorporates the concept of sustainability. Escalating the economy of a region is achievable by employing sustainable tourism. Balige is a priority destination on the national development agenda. Community participation may promote various aspects of sustainability, including the economy. This research aims to determine what forms of community participation can be employed to develop the economy. This study utilizes a mix of quantitative and qualitative methods. The data was collected through questionnaires, interviews, and observations. The research concludes with recommendations to develop the economy through community participation, helping to achieve sustainable tourism in Balige.
Evaluation of the efficiency of the different methods of teaching cardiopulmonary resuscitation to children and adolescents: integrative review
Authors: Franco de Oliveira Martins Laura , Bonine Melo Ana Júlia , Reis Daniel Brito , Alves Mateus Goulart
Published: March 2023

Objective: To evaluate the efficiency of different teaching methods of Basic Life Support for lay students from 12 years of age. Methods: A search was carried out for articles on the MEDLINE/PubMed and Lilacs/BVS platforms between December 2021 and January 2022 to answer the guiding question, "How effective are the different teaching methods of cardiopulmonary resuscitation for children and adolescents?". Articles published in English and Portuguese in the last five years were included. Results: Seven articles addressed teaching methods: self-regulated learning, training of teachers followed by students, peer education, online teaching associated with practical self-training, distance learning, digital training added to practice, and application use through a tablet with subsequent evaluation. In all studies, there was a comparison between intervention and conventional training. In general, all teaching methods contributed to developing the ability to act in trauma situations, but strategies that involved the presence of instructors in training showed better short- and long-term results. Conclusion: this study verified the findings in the literature regarding the effectiveness of different BLS teaching methods for children and adolescents. Among all approaches, better performance was observed in methods that had the presence of instructors, who offered feedback to students and reduced distractions. However, digital, self-regulated, and peer teaching also proved viable. Therefore, the choice of method should be based on the target audience's reality.
Characteristics and effects of physical exercise programs for older adults during the COVID-19 pandemic: an integrative review
Authors: Santos Vinícius Ramon da Silva , Damasceno Antonio Willyam Campos , Silva Maria Jasmine Gomes da , Cabral Danylo L Ferreira , Oliveira Augusto César Alves de
Published: March 2023

Objective: To evaluate the characteristics of physical exercise programs for older adults and their effects during the COVID-19 pandemic. Methods: An integrative review was conducted between January and March 2022. A search was conducted in MEDLINE via PubMed, Lilacs via BVS, PEDro, and Cochrane Library. Experimental articles (randomized clinical trials, non-randomized trials, or quasi-experimental studies) published from 2019 to 2021, with no language restriction, and that used physical exercise programs for older adults (> 60 years) in their intervention were included. The studies were selected by reading the title, abstract, and full text. The selected articles had their results extracted using an online form, tabulated using an electronic spreadsheet, and analyzed qualitatively and quantitatively. Results: 113 studies were identified; 7 met the eligibility criteria and were included in the review, all randomized controlled trials. The multi-component exercise programs were more frequent (resistance, balance, flexibility, and aerobic), delivered remotely and performed 2 to 7 times a week, lasting between 30 and 50 minutes. Significant effects were observed on physical function, body composition, blood triglycerides, the incidence of falls, physical activity, and functional capacity. Conclusions: The physical exercise programs used during the COVID-19 pandemic showed promising results for older adults. The programs proved to be a viable alternative for maintaining the physical, mental, and cognitive functions of older adults in times of public calamity.
Effect of clinical treatments for metabolic syndrome on albuminuria: a systematic review protocol
Authors: Peralva Bárbara Loures , Santos Kelli Borges dos , Lopes Marina Guedes Fraga , Lima Mario Flávio Cardoso de , Souza Claudio Teodoro de
Published: March 2023

Introduction: Metabolic syndrome (MetS) predicts cardiovascular disease, and patients with this condition and type 2 diabetes have increased albuminuria, significantly impacting cardiovascular mortality and kidney disease progression. A considerable number of interventions to control MetS exist and are considered efficient, including the use of medication and changes in lifestyle. However, which approaches are effective in controlling albuminuria remains unclear. This systematic review protocol aims to map in the available literature whether lifestyle, medication, and surgical intervention for MetS have an impact on reducing albuminuria in adult patients. Methods: The Joanna Briggs Institute methodology for systematic reviews will be followed. Cochrane Database of Systematic Reviews, Scopus, Embase, and MEDLINE/PubMed databases will be used. For the Gray Literature, the DART-Europe E-theses Portal. There will be no language restriction. Studies written after 2009 will be included due to the consensus and definition of metabolic syndrome. This review will include studies considering pharmacological and non-pharmacological treatments for controlling albuminuria in patients with MetS. Studies where MetS is described in children and adolescents, animals, pregnant women, and patients with type 1 diabetes will be excluded. First, the selection will be based on reading the title and summary of the texts retrieved in the search strategy, followed by reading the relevant texts in full by two reviewers. After the selection of the studies, the extraction of the data, analysis, and synthesis will be conducted according to the JBI methodology.
Вода --- источник электрически активных центров в CdHgTe
Authors: Сидоров Ю.Г. , Сидоров Г.Ю. , Варавин В.С.
Published: March 2023

Influence of water solutions with various pH and electrochemical treatment in cathode position on concentration of charge carriers in samples CdxHg1−xTe with x = 0.2−0.3 is investigated. Cathodic treatment cadmium-mercury-tellurium at small density current increases concentration of donors, and at high density acceptors are formed. It is supposed that hydroxyl groups create acceptors centers, introduce in interstitial cadmium-mercury-tellurium. At treatment for a long time (it is more than 20 h) or acceptors are formed with concentration at level of 1016 cm−3 (at high activity of hydrogen), or donors with concentration of 1014 cm−3 (at low activity of hydrogen) are uniform distribution on all thickness of cadmium-mercurytellurium film and does not vary with the subsequent increase in time of treatment.
Social Support Among Women With Potential Essure-Related Complaints: Analysis of Facebook Group Content
Authors: van Gastel Daniëlle , Antheunis Marjolijn L , Tenfelde Kim , van de Graaf Daniëlle L , Geerts Marieke , Nieboer Theodoor E , Bongers Marlies Y
Published: March 2023

Background

Social support groups are an important resource for people to cope with problems. Previous studies have reported the different types of support in these groups, but little is known about the type of reactions that sharing of personal experiences induce among members. It is important to know how and to what extent members of support groups influence each other regarding the consumption of medical care. We researched this in a web-based Facebook group of women sterilized with Essure. Essure was a device intended for permanent contraception. From 2015 onward, women treated with Essure for tubal occlusion raised safety concerns and numerous complaints.

Objective

This study aimed to evaluate the use of social support in a Facebook community named “Essure problemen Nederland” (EPN; in English, “Essure problems in the Netherlands”).

Methods

All posts in the closed Facebook group EPN between March 8 and May 8, 2018, were included. In total, 3491 Facebook posts were analyzed using a modified version of the Social Support Behavior Codes framework created by Cutrona and Suhr in 1992. Posts were abstracted and aggregated into a database. Two investigators evaluated the posts, developed a modified version of the Social Support Behavior Codes framework, and applied the codes to the collected data.

Results

We found that 92% of messages contained a form of social support. In 68.8% of posts, social support was provided, and in 31.2% of posts, social support was received. Informational and emotional support was the most frequently used form of provided social support (40.6% and 55.5%, respectively). The same distribution was seen with received social support: informational support in 81.5% and emotional support in 17.4% of cases. Our analysis showed a strong correlation between providing or receiving social support and the main form of social support (P<.001). In a total of only 74 (2.2%) cases, women advised each other to seek medical care.

Conclusions

The main purpose of women in the EPN Facebook group was to provide and receive informational or emotional support or both.