bluuebunny/crossref_metadata_2025 huggingface dataset:
The Quality and Motivation of the Workforce
Authors: Tanning Toivo , Tanning Lembo
Published: October 2024

- Labour quality and motivation has been a hot topic for businesses. It very much depends on the company's results and economic performance of the country as a whole. Below we analyze the new and old European Union (EU) member states' labour quality and motivation of the key indicators - productivity and wages, which is not only the factors. Generalizations will look at this as primarily Estonian-based emerging countries. Estonia can be regarded as a small European economic model, with its contradictions. Alongside the rapid economic growth and fiscal policy in accordance with the weak point of the labour market.
Some Typical Examples of the Application of Didactic Principle of Polyformism in the Teaching of Mathematics
Authors: Markovic Djoko G.
Published: October 2024

Teaching principles are the subject of research in light of didactic polyform principle and their positive correlative links, which they contribute to breaking of formalism in Mathematics Teaching for realization of the most important teaching goals, i.e. making the process more active and more dynamic and adopting deductive methods as the most significant way of thinking, complete acquisition proficiency and its applying to various mathematical and other situations. This work concerned with the Mathematics Teaching and especially the principle of polyform, introduced with geometrical-arithmetical-algebraic interpretation in function of dynamic teaching process with tendency of continuous offering of occasions to pupils for original and creative thinking in addition to development of habits of independent polyform thinking, critical evaluation and reasonable generalization.
Metamodel of the REA model level
Authors: Melis Zdenek , Zacek Jaroslav , Hunka Frantisek
Published: October 2024

This paper describes the gradual formation of the metamodel of the REA model level of the REA enterprise ontology. The paper aims to create a basic structure that allows creating valid models of the ontology. The first part of the paper discusses the identification of the elements used as a basis for the metamodel and their relationships. The second part describes the creation of the metamodel itself. This metamodel serves as the fundament for creating domain-specific modelling tool and can be used as a basis for an information system based on the REA enterprise ontology.
Ergenlerin Sosyal Medya Fenomenlerini Takip Etme Davranışlarının Sosyolojik Analizi
Authors: Aksoy Mehmet
Published: October 2024

Dijitalleşme süreci gönüllülüğe dayalı, herkesin herkesi gözetlediği, gözetleyenin de gözetlenen haline geldiği omniptik gözetim tipini inşa etmiştir. Sosyal medya platformlarını kullanan bireyler, bu mecraların aktörlerinden olan ‘sosyal medya fenomenlerinin’ paylaştığı içerikleri adeta eğlenerek, haz alarak takip etmektedirler. Dolayısıyla, omniptik gözetimin yeniden üretimine katkı yapan kitlelerden biri olan ergenlerin, sosyal medya fenomenlerini yoğun şekilde takip etmelerinin ve fenomenlerin yaptığı paylaşımlara beğeni yapmalarının arkasında bulunan saiklerin belirlenmesi bir problematik olarak karşımıza çıkmaktadır. Bu bağlamda araştırmanın amacı, ergenlik çağındaki lise öğrencilerinin sosyal medya fenomenlerini takip etme ve bu fenomenlerin çevrimiçi platformlarda paylaştığı içerikleri beğenme nedenlerini belirlemek; bu durumu kendi yaşamlarına nasıl ve niçin entegre ettiklerine ilişkin görüşlerini belirlemektir. Nitel yöntemin fenomenolojik deseniyle yürütülen ve amaçlı örnekleme yönteminin kullanıldığı bu araştırmada, 2023-2024 eğitim-öğretim yılında Eskişehir Cemal Mümtaz Sosyal Bilimler Lisesi’nde okuyan 25 öğrenci çalışma grubunu oluşturmuştur. Araştırmada 22 soruluk bir yarı yapılandırılmış görüşme formu kullanılmış, veriler için betimsel içerik analizi yapılmıştır. Araştırmada, lise öğrencilerinin ‘sosyal medya fenomenlerini’ yoğun şekilde takip ettikleri ve fenomenlerin paylaştığı içerikleri saatlerce izledikleri belirlenmiştir. Fenomenlerin, öğrencilerin karar vermelerinde bir güç haline geldikleri; öğrencilerin, sosyal medya fenomenliğini ‘kazanç elde etme ve maddi anlamda güçlenme’ olarak algıladıkları görülmüştür. Öğrencilerin, fenomenler üzerinden dijital kimliklerini, statülerini ve saygınlıklarını inşa etme yoluna gittikleri; fenomenleri motivasyon kaynağı ve kanaat önderi olarak algıladıkları; benlik sunumlarını fenomenler üzerinden yaptıkları anlaşılmıştır. Dolayısıyla, kimliğin inşa edildiği ergenlik çağındaki bireylerin sosyal medya fenomenlerini hedonik tavırla izleme davranışlarının; onların çevrimiçi personalarıyla özdeşim kurmalarına ve kendilik algılarını yitirmelerine; örtülmüş benliklerin ve ambalajlanmış egoların ortaya çıkmasına yol açabileceği, vurgulanması gereken bir nokta olmaktadır.
‘Akıllı Köy’ Projesinde Teknolojik Bir Yanılsama
Authors: Tunay Ceren
Published: October 2024

Akıllı Köy modeli, geleneksel köy yaşamının, bilgi ve iletişim teknolojilerinin kullanıldığı uygulamalarla donatıldığı bir kırsal yaşam modelidir. Akıllı Köyler, tarım ve hayvancılığı akıllı sistemlerle yeniden örgütleyerek kırsal alanlarda mevcut yaşam standartlarını iyileştirmeyi ve sürdürülebilirliği sağlamayı hedefler. Yaşam standartlarının iyileştirilmesi, mevcut yaşam standartlarının değişime uğraması anlamına gelmektedir. Bu değişim, sosyal ilişkilerde meydana gelebilecek değişimin de habercisi niteliğindedir. Dolayısıyla Akıllı Köy Projeleri, salt teknik uygulamalar olmanın ötesinde, sosyal yapıdan bağımsız düşünülemez ve bütünsel bir yaklaşım gerektirir. Bu makale, teknolojik uygulamaları, salt teknik birer uygulama olmalarının ötesinde, sosyo-kültürel boyuta nasıl yansıyabileceğini Türkiye’de uygulanan ilk Akıllı Köy Projesi üzerinden ele almayı amaçlamaktadır. Ayrıca, kapitalizmin şekillendirdiği yeni insan tipi de bu bağlamda analiz edilmektedir. Küreselleşmenin etkisiyle endüstriyel kapitalizm yeni bir boyut kazanmış; geleneksel olarak maddi varlıklara odaklanan sermaye, uluslararası finansal piyasaların etkisiyle artık finansal araçlara yönelmeye başlamıştır. Üretim tarzının finansal hareketlere dayandığı bu düzen, bireylerin ekonomik kararlarını öngörülemeyen bir düzleme yönlendirmiştir. Sürekli değişen piyasa koşulları bireyleri de dönüştürmüş ve yeni bir insan tipi yaratmıştır. Bireyler, yatırım fırsatları karşısında dürtüsel tepkiler vermeye daha yatkın hale gelmiştir. Dolayısıyla bu makale, geleneksel değerlerin hâkim olduğu kırsal bir yaşam alanında kurulan Akıllı Köy Projesinin sosyal, ekonomik ve teknolojik yönleri çerçevesinde, bu yeni insan tipinin nasıl tanımlandığı konusunda bir anlayış sağlamayı amaçlamaktadır.
Diasporada İslam’ın Barışa Açılan Yüzü: İslami Hip-Hop
Authors: Duman Bay Betül , Güler Zuhal
Published: October 2024

Hip-Hop, gençlerin kendilerini ifade etmelerine, sahici ve samimi şekilde toplumsala ve düzene karşı muhalif bir tutum sergilemelerine ve kendilerine özgü bir kimlik oluşturmalarına imkân sunan kentli ve muhalif bir kültürü temsil etmektedir. Yakın dönemde Hip-Hop’ın yaygınlaşması ve kültür endüstrisi içerisinde yer bulmasıyla birlikte muhalif niteliğini kaybetmeye başladığı iddia edilmektedir (Kadıoğlu ve Sözeri-Özdal, 2020). Bununla birlikte, diaspora Müslüman topluluklar arasında hem dini inancın hem de kültürel kimliğin yansıtılmasında İslami Hip-Hop halen önemli bir yer tutmaktadır (Chan-Malik, 2011a). Bu bağlamda, Avrupa’da Müslüman göçmenlerin kentli kuşaklarının, içinde doğup büyüdükleri ve belli derecede entegrasyon sağladıkları toplumda yaptıkları ve aynı zamanda doğuşunda 2001 sonrası yükselen İslamofobi’nin etkili olduğu bu müzik türünde İslam’ın nasıl temsil edildiği ve bu müziğin ne derece muhalif nitelik taşıdığı önem kazanmaktadır. Bu çalışma, diasporada gelişen İslami Hip-Hop’a odaklanmakta ve şarkı sözlerinde İslam’ın nasıl temsil edildiği ve bu müziğin ne derece muhalif nitelik taşıdığı sorularını sormaktadır. Çalışmanın kapsamını, Poetic Pilgrimage, Nasihat ve Islamic Force Hip-Hop grupları oluşturmaktadır. Adı geçen bu grupların çalışmanın kapsamına dahil edilmesinin nedeni, İslamofobinin yaygın olduğu Avrupa ülkelerinde rap yapan genç Müslümanlar arasında söz konusu grup üyelerinin etnik kimlik ve cinsiyet açısından çeşitlilik sergilemeleri ve yanı sıra popüler olmalarıdır. Çalışmada nitel araştırma desenlerinden içerik çözümlemesi kullanılmıştır. Rapçilerin yazdıkları şarkı sözleri -kendileri ile yapılan mülakatlar ve sosyal medya paylaşımları içerik çözümlemesine tabi tutulmuştur. Bu grupların, Sufizme ve evrensel değerlere dayalı, yerleşik kurumsal din ve dindarlığa mesafeli, bireysel bir maneviyat anlayışını benimsedikleri ve bunun da daha geniş bir dinleyiciye erişimi sağlayan önemli bir unsur olduğu sonucuna ulaşılmıştır. Şarkı sözlerinde hem anavatanlarında ve İslam ülkelerinde yerleşik Müslümanlık anlayışına hem de İslam’ın Batı’daki temsiline ciddi itirazların yöneltildiği görülmektedir. Bu yönüyle de muhalif niteliğini koruyan 2000’lerin kentli kuşak Müslüman Hip-Hop’çuların barışçıl bir İslam’ı temsil etmelerinde Doğu- Batı arasındaki kültürel konumlanmalarının ve melez kimliklerinin etkili olduğu vurgulanmaktadır.
Investor demand for stocks in Initial Public Offerings and their price behaviour after debut. Evidence from Poland
Authors: Gemra Kamil , Kwestarz Piotr
Published: October 2024

This article investigates the relationship between investor demand during an IPO and the long-term behaviour of share prices following a company’s stock market debut. Specifically, the study examines the impact of the demand observed during the public offering and the size of the offering on abnormal return rates for a sample of 116 IPOs on the Warsaw Stock Exchange between 2012 and mid-2022. The primary research hypothesis tests whether the medians of abnormal return rates, influenced by these factors, are statistically significant over several time intervals ranging from 3 to 12 months after the debut. The findings confirm that certain information from the completed public offering, particularly the relatively low number of new shares offered, plays a significant role in predicting abnormal changes in share prices during these periods. This research offers valuable insights for investors, emphasising the key factors within the IPO process that can influence the trajectory of share prices following a company’s market debut.
Precision surgical education
Authors: Domínguez Torres Luis Carlos , Vega Peña Neil Valentín , Sanabria Quiroga Álvaro Enrique
Published: October 2024

Information and data are accelerating the implementation of competency-based medical education. The adoption of precision education can contribute to this purpose. This article discusses the extent to which precision surgical education can be used in assessing the minimum reliability standards of future surgeons — given the advent of Entrustable Professional Activities — and as an option to strengthen the career trajectory of residents.
Enhancing Productivity of Chickpea Through Cluster Front Line Demonstration in Jaipur District of Rajasthan
Authors: Yadav Babu Lal , Khan Irfan , Singh Tej Partap , Rathore Shaitan Singh , Yadav Malu Ram , Gupta Mudit
Published: October 2024

Background: Chickpea is the premier pulse crop widely grown and consumed in India. Chickpea is an important pulse crop during winter season in Rajasthan. It also plays an important role in sustainable agriculture by improving the soil health through biological nitrogen fixation and by enhancing the soil microbial populations thus it is a good source of farmer livelihood and soil security. Methods: Krishi Vigyan Kendra, Chomu (Tankarda) Jaipur-1 conducted cluster frontline demonstrations on chickpea at farmers' field during winter season of 2019-20 and 2020-21. A total 100 demonstrations were conducted with an area of 40 hectare. A survey to get information on chickpea cultivation practices was undertaken before conducting the demonstrations. Selection of farmers and improved technology for demonstrations were done on the basis of survey information. Result: The results of the cluster frontline demonstrations observed that average yield of chickpea under demonstrations was 24.24 q/ha, which was 26.64 percent higher as compared to farmers practices (19.14 q/ha). The extension gap, technology gap and technology index were 5.10 q/ha, 2.56 q/ha and 9.56 percent respectively. Higher net return and B:C ratio recorded as ₹ 95432/ha and 4.76 under demonstration plot as compared to farmers practices (₹ 72920/ha and 4.25). The results of demonstrations observed that the low productivity at farmers’ fields may be enhanced through cluster frontline demonstrations (CFLD).
Realigning Social Protection Across the Nexus: Reflections from Protracted Crises in the Arab Region
Authors: Reid Charis , Both Nathalie , Pellerano Luca , Byrne Meredith , Sirisena Chantal Neomi , Ammar Zeina , Smith Gabrielle
Published: October 2024

Humanitarian emergencies are increasingly protracted and characterised by multiple compounding crises. International social security standards provide a roadmap for building national social protection systems. In the Arab States region, the International Labour Organization has been critically assessing how to apply these standards across the humanitarian, development, and peace nexus when countries face protracted crises. This article presents case studies in four countries: Iraq, Jordan, Lebanon, and the Occupied Palestinian Territory. It addresses questions on how to strengthen humanitarian–development transitions using international standards, where entry points exist or challenges remain, and how these transitions may contribute to strengthening peace through social cohesion.
KİLİSLİ ZİHNÎ’NİN GAZELLERİNDE ‘GAM’ KAVRAMI
Authors: Turhan Şerife Gaye , Şener Hasan
Published: October 2024

İslâm medeniyeti dairesinde gelişen klasik Türk şiirinde gam kavramı birçok şair tarafından farklı hayallere konu edilmiştir.
“Keder, üzüntü, acı ve sıkıntı” anlamlarına gelen gam genellikle aşk kavramı ile iç içe geçmiş bir duygudur. Bu iki kavram arasındaki ilişki, divan şiirinin merkezinde yer alır. Aşkın yoğunluğu, gamı da beraberinde getirir. Gam, âşık için âdeta bir mihenk taşıdır; âşığın aşk yolunda ne derece arzulu, hevesli ve dayanıklı olduğunu gösterir. Gam, bazen âşığın sevgiliye duyduğu hasreti, özlemi ve onunla bir araya gelememenin verdiği hüznü dile getirirken bazen de manevî bir arayışın ifadesi olarak ele alınır. Gam, bir tür içsel aydınlanma ve kendini keşfetme aracı olarak da görülebilir. İnsan hayatının geçiciliği, aşkın ilahi boyutu ve varoluşsal sorgulamalar, gamın anlamını derinleştirir. Gamın şiirde işleniş biçimi ve gam etrafında oluşturulan hayallerde kullanılan dil, dîvân şiirinde bu duyguların ifade edilmesinde belirleyici bir rol oynar.
XIX. Yüzyılın ilk yarısında yaşamış ve İstanbul dışında yetişmiş güçlü şairlerden biri olarak kabul edilen Kilisli Zihnî (d. 1251/1835- ö. 1309/1891) Dîvân’ında gam kavramına özellikle gazellerinde sıkça yer vermiştir. Bu çalışmada, Kilisli Zihnî’nin hayatı ve edebî şahsiyeti hakkında kısaca bilgi verildikten sonra onun Dîvân’ında gam kavramının kullanıldığı bağlamlar ve anlamlar tespit edilip incelenmiş ve beyitler üzerinden açıklanmıştır.
Assessing the impact of virtual reality on the restoration of motor function in the acute period of ischemic stroke
Authors: Lakhov A. S. , Starikovskiy M. Yu. , Poverennova I. E. , Kurov M. V. , Persteneva N. P.
Published: October 2024

Aim: to evaluate the effectiveness of using virtual reality to restore motor function in patients in the acute period of ischemic stroke.

Material and methods. We studied 207 patients in the acute period of ischemic stroke, who were divided into two groups by randomization: study group – 105 patients, comparison group – 102 patients. All patients received all necessary standardized therapy. Patients in the study group additionally received classes using the ReviVR device. Efficacy was assessed using the NIHSS, FMA-LE, and BBS scales.

Results. On all scales studied, patients in the study group demonstrated better results in relation to the comparison group, both in terms of the final result and in terms of the level of change in indicators during the rehabilitation process. The use of virtual reality made it possible to reduce disability on the NIHSS scale to 7.0 (4.0; 9.0) points, which is better than the results of the comparison group – 9.0 (5.0; 13.0) points with a high level of significance p < 0.001. The increase in motor function according to FMA-LE in the study group was higher and amounted to 21.0 (15.0; 24.0) points versus 18.0 (7.0; 22.0) points in the comparison group with a significance level of p = 0.002. The study group also showed better results on the BBS scale – 26.0 (17.0; 34.0) versus 18.0 (5.0; 29.0) points with a significance level of p < 0.001.

Conclusion. The use of virtual reality together with standardized therapy in the acute period of ischemic stroke is effective in restoring motor function of the affected lower limb, improving balance and reducing general disability in general.
Enhancing Trust and Embracing Vulnerability in the College Classroom: A Reflection on Ungrading and Co-Creation in Teaching and Learning
Authors: Meinking Kristina , Hall Eric
Published: October 2024

In this reflective essay, we explore how we and our students experienced trust and opened ourselves up to being vulnerable in two iterations of a course that was built on the pedagogies of ungrading and co-creation in teaching and learning (CCTL). As approaches that fall under the broader umbrella of critical pedagogy, ungrading usually involves an alternative to conventional alphanumeric grading systems, while co-creation in teaching and learning consists of a varied scale of student-and-instructor partnerships in the classroom. The course contexts explored here take ungrading to mean student self-assessment and self-assignment of grades, and our implementation of co-creation focused on significant elements of the course such as expectations, content, assignments, and assessments. We suggest that our combination of these pedagogies exposed the significance of vulnerability to nurturing trust in the college classroom. After an overview of the salient points in the literature on these pedagogies and a discussion of trust and vulnerability, we recollect our own experiences of them in a co-taught second-year honors course. Drawing from our reflections and those expressed in student writing, we observe that we brought a significant level of trust in each other and our students to the course. Further, we note that the processes of sharing authority embedded in both pedagogies significantly deepened that trust while also underscoring, in retrospect, the remarkable degree of vulnerability made accessible to students and instructors alike. Instructors who wish to implement these approaches should be keenly aware of the additional opportunities that trust and vulnerability, as made possible via these pedagogies, offer for building relationships in the classroom and working toward increased inclusivity and equity in the course community.
CARACTERIZAÇÃO CLÍNICO-EPIDEMIOLÓGICA DA DENGUE ENTRE A POPULAÇÃO PEDIÁTRIA NO BRASIL DE 2014 A 2020
Authors: Teixeira Martins Marcos Vinícius , Perius de Brito Veronica , Junes Mendes Gabriel , Rodrigues Moreira Marilia , Vilges de Oliveira Stefan
Published: October 2024

Introdução: A dengue é uma arbovirose com repercussões importantes na saúde pública, com alta demanda de atendimento médico pelo impacto na saúde física e na qualidade de vida dos afetados. No Brasil, fatores climáticos, demográficos e sociais favorecem a disseminação da doença. Nota-se uma mudança no perfil de acometidos, com aumento de casos em populações pediátricas. Objetivo: Descrever o perfil clínico-epidemiológico dos pacientes pediátricos com dengue no Brasil entre 2014 e 2020. Métodos: Utilizou-se dados secundários do Sistema de Agravos de Notificação (SINAN) do Ministério da Saúde do Brasil. Foram incluídos casos de dengue em pacientes com até 14 anos de idade. Os dados foram analisados utilizando estatísticas descritivas, testes Qui-quadrado e Análises de Correspondências Múltiplas (ACM). Resultados: Foram registrados 1.064.522 casos de dengue pediátrica no período estudado, com uma média anual de 152.075 notificações. A maioria dos casos evoluiu bem, com cura do paciente, e uma média anual de 6.042 casos necessitaram de internação. Houve um número médio anual de 44 casos de óbito relacionados à dengue. O sorotipo 1 foi o mais predominante. Os meses de fevereiro a maio tiveram maior número de notificações. A região Sudeste apresentou o maior número de casos. Discussão: Confirmou-se o aumento da dengue em crianças no Brasil, sobretudo entre aquelas de 10 a 14 anos. A análise dos dados revelou associações entre variáveis como região, etnia e faixa etária com a evolução e gravidade dos casos. Os resultados podem subsidiar intervenções efetivas para o controle da dengue no país. Conclusões: A dengue continua sendo um problema de saúde pública, afetando especialmente a população pediátrica. É necessário adotar medidas de prevenção e controle mais efetivas, direcionadas às especificidades dessa faixa etária, a fim de reduzir a morbidade e mortalidade associadas à doença.
DISTRIBUIÇÃO EPIDEMIOLÓGICA DOS CASOS INCIDENTES DE HANSENÍASE EM UM ESTADO DO NORDESTE BRASILEIRO
Authors: Lima Filho Carlos Antonio de , Barros Mariana Boulitreau Siqueira Campos , Mendes Neta Beatriz , Santos José Winglinson de Oliveira , Bernardino Amanda de Oliveira , Anjos Evilyn Rachel Teixeira Barreto dos , Souza Eishylla Alessandra da Exaltação , Souza Pedro Marconi Aragão de , Apratto Giovanna dos Anjos , Lira Maria da Conceição Cavalcanti de
Published: October 2024

Objetivo: analisar o perfil epidemiológico dos casos novos de hanseníase no Estado de Pernambuco, entre os anos de 2012 e 2022. Método: pesquisa ecológica, transversal de natureza descritiva e retrospectiva, com abordagem quantitativa, realizado através de dados do Sistema de Informação de Agravos de Notificação. Foram analisadas as variáveis: sexo, escolaridade, raça, faixa etária, classe operacional, forma clínica, avaliação da incapacidade, baciloscopia e esquema terapêutico adotado. Foi realizada a análise descritiva através de medidas absolutas e relativas, além do levantamento de indicadores preconizados pela OMS. Resultados: foram diagnosticados 24.470 novos casos de hanseníase em Pernambuco, a análise espacial mostrou uma grande concentração na região metropolitana. As variáveis sociodemográficas mostraram maior predominância do sexo feminino (50,21%), raça parda (58,33%), maiores de 15 anos (91,59%), com baixa escolaridade. As variáveis clínicas mostram uma maior prevalência de casos multibacilar (62,89%), de forma clínica dimorfa (36,33%), apresentando grau zero de incapacidade (62,54%), onde 49,50% não realizam a baciloscopia, e 61,56% foram encaminhados para 12 doses da poliquimioterapia. Conclusão: É possível observar que a hanseníase ainda atrelada aos determinantes sociais e de saúde, o seu diagnóstico está sendo realizado de modo tardio, contribuindo para o ocultamento da real prevalência.
Postoperative extraperitoneal bladder injury after metal pelvic osteosynthesis for pelvic injury
Authors: Abdullahi Khalid , George Obadele Olusegun , Olalekan Ajiboye Lukman , Isiyaku Abubakar , Sadiq Muhammad Abubakar , Garba Aljannare Bashir , Kingsley Okezie Chukwuebuka , Peter Agwu Ngwobia
Published: October 2024

Bladder injury is one of the recognized entities of the genitourinary organ system trauma. The causes are numerous, including road traffic crashes, falls from heights, gunshot injuries, and iatrogenic causes, among others. In some cases, the diagnosis may be difficult to make or missed, resulting in severe morbidity. Postoperative implant-associated bladder injury is a rare and unfamiliar etiology in our setting. This article discusses the case of a 60-year-old farmer who sustained polytrauma in a road traffic crash, including pelvic fracture and urethral distraction injury, among others. He had a pelvic implant during the initial surgical intervention as part of resuscitation or damage control surgery. However, urine started to leak from his suprapubic wound a few days after operation. This condition was persistent despite continuous bladder drainage with an indwelling urethral catheter. He subsequently had bladder re-exploration, which confirmed an anterior bladder wall perforation secondary to the dislodged pelvic implant. Bladder injury due to pelvic implant is rare, but possible. Bladder exploration is warranted and rewarding in patients with suspicion of persistent vesicocutaneous fistula following pelvic implant surgery.
Cloning and Mutagenesis of AmpC β–lactamase in Pseudomonas aeruginosa for the Identification of Targetable Allosteric Sites
Authors: Bhat Shriya , Lory Stephen
Published: October 2024

The opportunistic pathogen Pseudomonas aeruginosa is responsible for numerous chronic infections and has a case fatality rate of 50%. All P. aeruginosa strains express β–lactamase, an enzyme capable of inactivating β–lactam antibiotics, including penicillins. However, β–lactams are still considered desirable therapeutics by physicians due to their low toxicity. The short-term goal of this study was to create an optimal model for ampC expression in P. aeruginosa and determine the selecting antibiotic to be used during mutagenesis. In the long term, this study aims to renew effectiveness of β–lactams by identifying potential allosteric binding sites on β–lactamase for the development of novel β–lactamase inhibitors. To create a system for ampC expression, the chromosomal P. aeruginosa ampC gene encoding for β–lactamase was cloned into Escherichia coli, then conjugated into P. aeruginosa ∆ampC. β– lactamase assays on recombinant E. coli and P. aeruginosa detected much higher production of β–lactamase in pMMB67HE, which was confirmed with antibiotic susceptibility testing (AST) to numerous β-lactams. From AST, carbenicillin was chosen as the antibiotic to select functional β–lactamase production during mutagenesis. Future work includes conducting mutagenesis on ampC to identify allosteric binding sites on the β–lactamase enzyme that may enable the discovery of new β–lactamase inhibitors. This work allows for the development of novel β–lactamase inhibitors that could renew the utility of β–lactams and drastically reduce morbidity and mortality from chronic Pseudomonas infections.
Radiogenomics Pilot Study: Association Between Radiomics and SNP-Based Microarray Copy Number Variation in Diagnosing Renal Oncocytoma and Chromophobe Renal Cell Carcinoma
Authors: Alhussaini Abeer J. , Veluchamy Abirami , Kernohan Neil , Palmer Colin N. A. , Steele J. Douglas , Nabi Ghulam
Published: October 2024

Background: RO and ChRCC are kidney tumours with overlapping characteristics, making differentiation between them challenging. Objectives: The objective of this research is to create a radiogenomics map by correlating radiomic features to molecular phenotypes in ChRCC and RO, using resection as the gold standard. Methods: Fourteen patients (6 RO and 8 ChRCC) were included in the study. A total of 1,875 radiomic features were extracted from CT scans, alongside 632 cytobands containing 16,303 genes from the genomic data. Results: Feature selection algorithms applied to the radiomic features resulted in 13 key features. From the genomic data, 24 cytobands highly correlated with histology were selected and cross-correlated with the radiomic features. The analysis identified four radiomic features that were strongly associated with seven genomic features. Conclusion: These findings demonstrate the potential of integrating radiomic and genomic data to enhance the differential diagnosis of RO and ChRCC, paving the way for more precise and non-invasive diagnostic tools in clinical practice.
Enabling Dynamic Human-Robot Collaboration: A Holistic Framework for Assembly Planning
Authors: Schirmer Fabian , Kranz Philipp , Rose Chad G. , Schmitt Jan , Kaupp Tobias
Published: October 2024

The combination of humans’ cognitive skills and dexterity with the endurance and repeatability of robots is a promising approach to modern assembly. However, planning an assembly sequence and efficiently allocating tasks between humans and robots is a manual, complex, and time-consuming challenge. This work presents a framework named “Extract-Enrich-Assess-Plan-Review" that facilitates holistic planning of human-robot assembly processes. The framework uses heterogeneous data sources to feed a planning algorithm that generates assembly sequences according to various boundary conditions such as resource capability, part dependency, sequencing, and adaptability to human behavior. An expert remains in the loop to enrich the data, review, and modify the automatically generated sequences. As an output, the framework creates assembly sequences with different ways in which humans and robots work together that can be selected depending on the purpose of the subsequent use. For our experimental results, we compare the achieved degree of automation using three different CAD formats. We also demonstrate and analyse multiple assembly sequence plans that are generated by our system. Those assembly plans incorporate different human-robot interaction modalities that are synchronised, cooperative, or collaborative.
The Path to Poverty Reduction: How Economic Growth and Fiscal Policy Influence Poverty through Inequality in Indonesia?
Authors: Agussalim Agussalim , Nursini Nursini , Suhab Sultan , Kurniawan Randi , Samir Salman , Tawakkal Tawakkal
Published: October 2024

One of the factors leading to the slow decline in poverty in Indonesia is the lack of government at-tention to reduce income inequality. Fiscal policy and economic growth can effectively reduce poverty after lowering income inequality, so the inequality channel must be considered. Socioec-onomic and infrastructure differences between provinces can influence the effectiveness of eco-nomic growth and fiscal policy in reducing poverty. This study aims to assess the effects of eco-nomic growth and fiscal policy on spending and taxes on direct and indirect poverty reduction through lowering income inequality and how these variables influence poverty by province. This study employed secondary data, including panel data for 2010-2023 from 34 provinces in Indo-nesia, which were analyzed using an autoregressive cross-lagged SEM model. The study finds that economic growth and fiscal policy on spending on education and health are statistically sig-nificant in reducing poverty directly in non-Java but do not affect it through income inequality. Taxes increase income inequality, and the social safety net does not reduce poverty outside Java. Increased spending on education and health should continue, with improvements in targeting so-cial safety nets and tax reforms needed to make the system more progressive and reduce inequality
Bone Marrow Stem Cell Population in Single and Multiple Level Aspiration
Authors: Che Xiangguo , Kim Hee-June , PhD Xian Jin , Kim Joon-Woo , Park Kyeong-Hyeon , Lim Jeong-Ok , Kyung Hee-Soo , Oh Chang-Wug , Choi Je-Yong
Published: October 2024

Background: Bone marrow aspiration concentrate (BMAC) has garnered increasing interest due to its potential for healing musculoskeletal injuries. While the iliac crest remains a common harvest site, the aspiration technique’s efficacy in offering the highest yield and prevalence of mesen-chymal stem cells (MSCs) is controversial. This study aimed to compare two different techniques of bone marrow aspiration over the anterior iliac crest from a single level (SL) versus multiple level (ML).
Methods: Anterior iliac crests were selected in 9 adult patients (aged between 31 and 59 years old). Aspiration was achieved using an 11-gauge needle (length: 100 mm; diameter: 2.3 mm) specifically manufactured for bone marrow collection (BD, Becton, US) connected to a 10-mL syringe. On one side, 4cc of bone marrow was aspirated at an SL to a depth of 7cm without changing the needle direction. On the other side, over the same portion of the iliac crest, 1 cc of bone marrow was obtained from ML of different depths during needle retrieval, maintaining a distance of 1cm and changing the tip direction. The samples were blindly sent to the laboratory without indicating whether they came from an SL or ML. Fluorescence-activated cell sorting (FACS) and osteoblast differentiation were analyzed and compared.
Results: In the FACS analysis, the SL resulted in a higher population of MSCs that were positive for CD105, CD73, and CD90 and negative for CD34, compared to the ML method. In the process of osteoblast differentiation, it was observed that MSCs exhibited more advanced features of en-hanced osteoblastic abilities in the SL method rather than the ML method.
Conclusion: An SL aspiration technique at the anterior iliac crest may produce a high-quality bone marrow aspirate. This technique may help obtain specific populations of MSCs with the desired characteristics for use in regenerative therapies for musculoskeletal injuries.
Neurogenic Aging After Spinal Cord Injury: Highlighting the Unique Characteristics of Aging After Spinal Cord Injury
Authors: Tretter Brittany Lynn , Dolbow David R , Ooi Vincent , Farkas Gary J , Miller Joshua M , Gorgey Ashraf S
Published: October 2024

Emanating from several decades of study into the effects of the aging process after spinal cord injury (SCI), "accelerated aging" has become a common expression as the SCI accelerates the onset of age-related pathologies. However, the aging process follows a distinct trajectory, characterized by unique patterns of decline that differ from those observed in the general population without SCI. Aging brings significant changes to muscles, bones, and hormones, impacting overall physical function. Muscle mass and strength begin to decrease with a reduction in muscle fibers and impaired repair mechanisms. Bones become susceptible to fractures as bone density decreases. Hormonal changes combined with decreased physical activity accelerate the reduction of muscle mass and increase in body fat. Muscle atrophy and skeletal muscle fiber type transformation occur rapidly and in a unique pattern after SCI. Bone loss develops more rapidly and results in an increased risk of fractures in body regions unique to individuals with SCI. Other factors, such as excessive adiposity, decreased testosterone and human growth hormone, and increased systemic inflammation, contribute to a higher risk of neuropathically driven obesity, dyslipidemia, glucose intolerance, insulin resistance, and increasing cardiovascular disease risk. Cardiorespiratory changes after SCI result in lower exercise heart rates, decreased oxygenation, and mitochondrial dysfunction. While it is important to acknowledge the accelerated aging processes after SCI, it is essential to recognize the distinct differences in the aging process between individuals without physical disabilities and those with SCI. These differences, influenced by neuropathology, indicate that it may be more accurate to describe the aging process in individuals with chronic SCI as neurogenic accelerated aging (NAA).
Research should continue to address conditions associated with NAA and how to ameliorate the accelerated rate of premature age-related conditions. This review focuses on the processes of NAA and the differences compared to the aging process in those without SCI. Recommendations are provided to help slow the development of premature aging conditions.
Median Based Unit Weibull (MBUW): A New Unit Distribution Properties
Authors: Attia Iman
Published: October 2024

A new 2 parameter unit Weibull distribution is defined on the unit interval (0,1). The methodology of deducing its PDF, some of its properties and related functions are discussed. The paper is supplied by many figures illustrating the new distribution and how this can make it illegible to fit a wide range of skewed data. The new distribution holds a name (Attia) as a nickname.
Unlocking Industrial Testosterone Production: Engineering Aspergillus nidulans Strain Deficient in Steroid 11-α-Hydroxylase Activity and Expressing 17-β-Hydroxysteroid Dehydrogenase Enzyme
Authors: Ortega-de los Ríos Lidia , Getino Luis , Galán Beatriz , García José Luis , Luengo José M. , Chamizo-Ampudia Alejandro , Fernández-Cañón José M.
Published: October 2024

Testosterone holds significant medical and economic importance, with the global market for testosterone replacement therapies valued at approximately $1.9 billion in 2023. This hormone is essential for the development and maintenance of male sexual characteristics as well as bone and muscle health. It plays a key role in conditions such as hypogonadism, muscle disorders, and andropause. However, the industrial production of testosterone often involves complex chemical processes that result in low yields, high costs, and environmental damage. Microbial biotransformation of steroids presents an eco-friendly alternative to traditional chemical synthesis. A knockout strain of Aspergillus nidulans deficient in steroid 11-α-hydroxylase activity was developed, rendering it incapable of hydroxylating androstenedione, progesterone, and testosterone. In this strain, two newly identified CYP450 enzymes—CYP68L1 from A. nidulans and CYP68L8 from Aspergillus ochraceus—were expressed to confirm their roles as steroid 11-α-hydroxylases. These enzymes successfully hydroxylated steroids such as androstenedione, progesterone, and testosterone. The availability of these 11-α-hydroxylases represents significant progress toward achieving efficient single-step steroid fermentation. Furthermore, the A. nidulans knockout strain is proposed as an effective model for studying the conversion of androstenedione to testosterone owing to its inability to hydroxylate the testosterone produced during bioconversion.
A Charged Relativistic Engine Based on a Permanent Magnet
Authors: Yahalom Asher , Sharma Prachi
Published: October 2024

This paper aims to describe and analyze a relativistic engine that uses a permanent magnet and an electrically charged device. According to Newton’s third law, every action is met with an equal and opposite reaction, meaning the total force in a system unaffected by external forces is zero. However, relativity principles state that signals cannot travel faster than the speed of light, so actions and reactions cannot occur simultaneously. As a result, the total force cannot be zero at any given moment. This implies that the system gains mechanical momentum and energy over a finite period. The question then arises about how to uphold the law of momentum and energy conservation. It has been shown that the momentum is balanced by an equal and opposite momentum in the field, while the energy gained by the engine is offset by a reduction in the field’s energy. Previous analyses assumed that the bodies involved were macroscopically neutral, meaning the number of electrons and ions was equal in every volume element. This paper relaxes that assumption and examines charged bodies interacting with magnetic currents from permanent magnetic materials, exploring the implications for a charged relativistic engine based on a permanent magnet.
Research on Optimal Design of Ultra-High-Speed Motors Based on Multi-Physical Field Coupling Under Mechanical Boundary Constraints
Authors: Bu Jianguo , Zhang Weifeng , Yu Yan , Pang Hailong , Lei Wei
Published: October 2024

With the rapid development of modern industrial technology, ultra-high-speed motors have demonstrated tremendous application potential in fields such as aerospace, high-speed machining, and micro-mechanical systems due to their high efficiency, high power density, and compact structure. However, the design of ultra-high-speed motors faces numerous challenges, particularly under mechanical boundary constraints, how to balance the interactions among electromagnetic performance, thermodynamic characteristics, mechanical strength, and other multi-physical fields has become a key factor limiting performance enhancement. This study first establishes a multi-physical field coupling model for ultra-high-speed motors, comprehensively considering the mutual influences of electromagnetic fields, temperature fields, and stress fields. Through finite element analysis, precise simulations are conducted on the electromagnetic distribution, heat conduction, mechanical stress, and rotor dynamics characteristics within the motor. Based on this, the impact of various design parameters (such as rotor structure, material selection, and cooling methods) on motor performance is investigated, revealing the variation laws of motor performance under multi-physical field coupling. With mechanical boundary constraints taken into account, this paper proposes an optimization design method for high-speed motors based on a multi-physical field coupling model. Initial samples are obtained through MaxPro experimental design, and a Kriging surrogate model is used for fitting. Subsequently, the NSGA-2 algorithm is employed for optimization design. During the optimization process, RMAE and RAAE are adopted for accuracy evaluation, and the Kriging model is iteratively updated based on the evaluation results until the optimal design of the ultra-high-speed motor is completed. This optimization design method enhances the overall performance of the motor while ensuring its mechanical boundary conditions and reducing the computational load during the optimization process. Experimental results demonstrate that the proposed multi-physical field coupling optimization design method can significantly improve the efficiency and power density of ultra-high-speed motors. This study not only provides theoretical support and technical guidance for the design of ultra-high-speed motors but also offers new ideas and methods for motor research and development in related fields. In the future, more efficient and intelligent optimization design algorithms will be explored to continuously advance ultra-high-speed motor technology.
Semantics Extension of Emo and Its Metonymic Use in Chinese Internet Language
Authors: Zhou Wei
Published: October 2024

The paper discusses the change of meaning and metonymium of Emo in Chinese cyber language here. Drawing on corpus-based analysis of emo posts published in the social media network Sina micro blog, we investigate how such aesthetics and sociocultural meanings attached to being “Emo”serves as a metonymy that enables diverse representations of affective states as well as situated emotion enactments. The findings suggest that the term “Emo”has been stretched as it is no longer confined to emotional events within or possibly just beyond emo, with a broader range of listings reflecting different emotions in various contexts. The metonymical nature of the use of “Emo”in Chinese reflects a broader cultural and social phenomenon occurring today in China -- particularly among some young net users. The research underscores the emotional expression pattern of Chinese netizens, which renders a good reference to comprehensively understand the evolution of language type in digital context.
Modeling and Predicting Self-Organization in Dynamic Systems Out of Thermodynamic Equilibrium; Part 1
Authors: Brouillet Matthew , Georgiev Georgi Y
Published: October 2024

Self-organization in complex systems is a process in which internal entropy is reduced and emergent structures appear that allow the system to function in a more competitive way with other states of the system or with other systems. It occurs only in the presence of energy gradients, facilitating energy transmission through the system and entropy production. Being a dynamic process, self-organization requires a dynamic measure and dynamic principles. The principles of decreasing unit action and increasing total action and the principle of decreasing unit entropy and increasing total entropy are dynamic variational principles that are viable to utilize in a self-organizing system. Based on this, average action efficiency can serve as a quantitative measure of the degree of self-organization. Positive feedback loops connect this measure with all other characteristics of a complex system, providing all of them with a mechanism for exponential growth, and indicating power law relationships between each of them as confirmed by data and simulations. In this study, we apply those principles and the model to agent-based simulations of ants traveling between two locations on a 2D grid. We find that those principles explain self-organization well and that the results confirm the model. We derive a compact model of ant-behavior based on the action of their trajectories, and then estimate a variety of metrics from the simulated behavior. By measuring action efficiency we can have a new answer to the question: "What is complexity and how complex is a system?". This work shows the explanatory and predictive power of those models, which can help understand and design better complex systems.
Preference-Aware Graph Diffusion Network and BiLSTM for Course Recommendation
Authors: Duan Chao , Cui Qiaoling , Xue Yu , Wan Xuelian , He Bin
Published: October 2024

Course recommendation is an important service of Intelligent tutoring systems (ITS), the rapid development of large-scale online courses has generated a substantial amount of learning process data for online learning platforms, providing valuable support for understanding learners' interests and preferences. However, despite made considerable achievements, there are still unresolved challenges:(1) Current research neglects the sequential relationship between the course learners learn. (2) It does not take advantage of the differences in learners' interest in different courses during the knowledge dissemination process. To overcome these challenges, we propose an innovative solution called PGDB (Preference-aware graph diffusion network and BiLSTM) for course recommendation. Specifically, we analyze learners' preferences for courses and relational paths using a relation-aware multi-head attention network, learn the semantic diversity of different contexts, effectively distinguish the difference of learners' interest in different courses in the process of knowledge transmission. In addition, the temporal preference modeling module employs a bi-directional long short-term memory network to mine learners' interest evolution patterns, generating learner-dependent representations, efficient use of the sequential relationship between the courses taken by learners. Experimental results on real datasets demonstrate that the proposed model greatly exceeds the performance of the most recent baseline models, thereby validating the model's effectiveness.