bluuebunny/crossref_metadata_2025 huggingface dataset:
Viscoelastic Characterization of Parasagittal Bridging Veins and Implications for Traumatic Brain Injury: A Pilot Study
Authors: García-Vilana Silvia , Sánchez-Molina David , Llumà Jordi , Galtés Ignasi , Velázquez-Ameijide Juan , Rebollo-Soria M. Carmen , Arregui-Dalmases Carlos
Published: October 2021

Many previous studies on the mechanical properties of Parasagittal Bridging Veins (PSBVs) found that strain rate had a significant effect on some mechanical properties, but did not extensively study the viscoelastic effects, which are difficult to detect with uniaxial simple tensile tests. In this study, relaxation tests and tests under cyclic loading were performed, and it was found that PSBVs do indeed exhibit clear viscoelastic effects. In addition, a complete viscoelastic model for the PSBVs is proposed and data from relaxation, cyclic load and load-unload tests for triangular loads are used to find reference values that characterize the viscoelastic behavior of the PSBVs. Although such models have been proposed for other types of blood vessels, this is the first study that clearly demonstrates the existence of viscoelastic effects from an experimental point of view and also proposes a specific model to explain the data obtained. Finally, this study provides reference values for the usual viscoelastic properties, which would allow more accurate numerical simulation of PSBVs by means of computational models.
Comparison of the Mineral and Nutraceutical Profiles of Elephant Garlic (Allium ampeloprasum L.) Grown in Organic and Conventional Fields of Valdichiana, a Traditional Cultivation Area of Tuscany, Italy
Authors: Loppi Stefano , Fedeli Riccardo , Canali Giulia , Guarnieri Massimo , Biagiotti Stefano , Vannini Andrea
Published: October 2021

In the Valdichiana area (Tuscany, Italy) an ancient native landrace of elephant garlic (Allium ampeloprasum L.), locally known as “Aglione della Valdichiana”, has long been cultivated. The aim of this study was to check whether there are differences in the mineral and nutraceutical profiles of the Aglione della Valdichiana cultivated conventionally and organically. Based on the analysis by ICP-MS of a wide array of major, minor, essential, and non-essential trace elements as well as rare earth elements, and the evaluation of the content of polyphenols, flavonoids, antioxidants, soluble proteins, soluble sugars, and starch, as well as the weight and water content, it was concluded that differences in the mineral and nutraceutical profiles of organically and conventionally grown bulbs were very limited. Only a statistically (p < 0.05) higher concentration of Cd (+2620%), Co (+113%), Mn (+55%), Rb (+180%), and Sb (+180%), as well as glucose (+37%) in conventionally cultivated bulbs emerged. Cadmium was the only element slightly higher than in the “reference plant,” but with a negligible risk (three orders of magnitude lower) for human health based on consumption. It is concluded that we failed to find evidence of healthier food or a higher nutraceutical quality for organically cultivated elephant garlic.
Automated Fiber Diameter and Porosity Measurements of Plasma Clots in Scanning Electron Microscopy Images
Authors: Daraei Ali , Pieters Marlien , Baker Stephen R. , de Lange-Loots Zelda , Siniarski Aleksander , Litvinov Rustem I. , Veen Caroline S. B. , de Maat Moniek P. M. , Weisel John W. , Ariëns Robert A. S. , Guthold Martin
Published: October 2021

Scanning Electron Microscopy (SEM) is a powerful, high-resolution imaging technique widely used to analyze the structure of fibrin networks. Currently, structural features, such as fiber diameter, length, density, and porosity, are mostly analyzed manually, which is tedious and may introduce user bias. A reliable, automated structural image analysis method would mitigate these drawbacks. We evaluated the performance of DiameterJ (an ImageJ plug-in) for analyzing fibrin fiber diameter by comparing automated DiameterJ outputs with manual diameter measurements in four SEM data sets with different imaging parameters. We also investigated correlations between biophysical fibrin clot properties and diameter, and between clot permeability and DiameterJ-determined clot porosity. Several of the 24 DiameterJ algorithms returned diameter values that highly correlated with and closely matched the values of the manual measurements. However, optimal performance was dependent on the pixel size of the images—best results were obtained for images with a pixel size of 8–10 nm (13–16 pixels/fiber). Larger or smaller pixels resulted in an over- or underestimation of diameter values, respectively. The correlation between clot permeability and DiameterJ-determined clot porosity was modest, likely because it is difficult to establish the correct image depth of field in this analysis. In conclusion, several DiameterJ algorithms (M6, M5, T3) perform well for diameter determination from SEM images, given the appropriate imaging conditions (13–16 pixels/fiber). Determining fibrin clot porosity via DiameterJ is challenging.
Primary Mediastinal and Testicular Germ Cell Tumors in Adolescents and Adults: A Comparison of Genomic Alterations and Clinical Implications
Authors: Urbini Milena , Schepisi Giuseppe , Bleve Sara , Virga Alessandra , Gianni Caterina , Gurioli Giorgia , Ulivi Paola , De Giorgi Ugo
Published: October 2021

Mediastinal germ cell tumors (MGCTs) share histologic, molecular and biomarkers features with testicular GCTs; however, nonseminomatous MGCTs are usually more aggressive and have poorer prognosis than nonseminomatous TGCTs. Most nonseminomatous MGCT cases show early resistance to platinum-based therapies and seldom have been associated with the onset of one or more concomitant somatic malignancies, in particular myeloid neoplasms with recent findings supporting a common, shared genetic precursor with the primary MGCT. Genomic, transcriptomic and epigenetic features of testicular GCTs have been extensively studied, allowing for the understanding of GCT development and transformation of seminomatous and nonseminomatous histologies. However, MGCTs are still lacking proper multi-omics analysis and only few data are reported in the literature. Understanding of the mechanism involved in the development, in the progression and in their higher resistance to common therapies is still poorly understood. With this review, we aim to collect all molecular findings reported in this rare disease, resuming the similarities and disparities with the gonadal counterparts.
Characterization of Microtubule Destabilizing Drugs: A Quantitative Cell-Based Assay That Bridges the Gap between Tubulin Based- and Cytotoxicity Assays
Authors: Laisne Marie-Catherine , Michallet Sophie , Lafanechère Laurence
Published: October 2021

(1) Background: Microtubule depolymerizing agents (MDAs) are commonly used for cancer treatment. However, the therapeutic use of such microtubule inhibitors is limited by their toxicity and the emergence of resistance. Thus, there is still a sustained effort to develop new MDAs. During the characterization of such agents, mainly through in vitro analyses using purified tubulin and cytotoxicity assays, quantitative comparisons are mandatory. The relationship between the effect of the drugs on purified tubulin and on cell viability are not always direct. (2) Methods: We have recently developed a cell-based assay that quantifies the cellular microtubule content. In this study, we have conducted a systematic comparative analysis of the effect of four well-characterized MDAs on the kinetics of in vitro tubulin assembly, on the cellular microtubule content (using our recently developed assay) and on cell viability. (3) Conclusions: These assays gave complementary results. Additionally, we found that the drugs’ effect on in vitro tubulin polymerization is not completely predictive of their relative cytotoxicity. Their effect on the cellular microtubule content, however, is closely related to their effect on cell viability. In conclusion, the assay we have recently developed can bridge the gap between in vitro tubulin assays and cell viability assays.
Altered Expression of Shorter p53 Family Isoforms Can Impact Melanoma Aggressiveness
Authors: Tadijan Ana , Precazzini Francesca , Hanžić Nikolina , Radić Martina , Gavioli Nicolò , Vlašić Ignacija , Ozretić Petar , Pinto Lia , Škreblin Lidija , Barban Giulia , Slade Neda , Ciribilli Yari
Published: October 2021

Cutaneous melanoma is the most aggressive form of skin cancer. Despite the significant advances in the management of melanoma in recent decades, it still represents a challenge for clinicians. The TP53 gene, the guardian of the genome, which is altered in more than 50% of human cancers, is rarely mutated in melanoma. More recently, researchers started to appreciate the importance of shorter p53 isoforms as potential modifiers of the p53-dependent responses. We analyzed the expression of p53 and p73 isoforms both at the RNA and protein level in a panel of melanoma-derived cell lines with different TP53 and BRAF status, in normal conditions or upon treatment with common anti-cancer DNA damaging agents or targeted therapy. Using lentiviral vectors, we also generated stable clones of H1299 p53 null cells over-expressing the less characterized isoforms Δ160p53α, Δ160p53β, and Δ160p53γ. Further, we obtained two melanoma-derived cell lines resistant to BRAF inhibitor vemurafenib. We observed that melanoma cell lines expressed a wide array of p53 and p73 isoforms, with Δ160p53α as the most variable one. We demonstrated for the first time that Δ160p53α, and to a lesser extent Δ160p53β, can be recruited on chromatin, and that Δ160p53γ can localize in perinuclear foci; moreover, all Δ160p53 isoforms can stimulate proliferation and in vitro migration. Lastly, vemurafenib-resistant melanoma cells showed an altered expression of p53 and p73 isoforms, namely an increased expression of potentially pro-oncogenic Δ40p53β and a decrease in tumor-suppressive TAp73β. We therefore propose that p53 family isoforms can play a role in melanoma cells’ aggressiveness.
The Potential Role of Cytokines and Growth Factors in the Pathogenesis of Alzheimer’s Disease
Authors: Ogunmokun Gilbert , Dewanjee Saikat , Chakraborty Pratik , Valupadas Chandrasekhar , Chaudhary Anupama , Kolli Viswakalyan , Anand Uttpal , Vallamkondu Jayalakshmi , Goel Parul , Paluru Hari Prasad Reddy , Gill Kiran Dip , Reddy P. Hemachandra , De Feo Vincenzo , Kandimalla Ramesh
Published: October 2021

Alzheimer’s disease (AD) is one of the most prominent neurodegenerative diseases, which impairs cognitive function in afflicted individuals. AD results in gradual decay of neuronal function as a consequence of diverse degenerating events. Several neuroimmune players (such as cytokines and growth factors that are key players in maintaining CNS homeostasis) turn aberrant during crosstalk between the innate and adaptive immunities. This aberrance underlies neuroinflammation and drives neuronal cells toward apoptotic decline. Neuroinflammation involves microglial activation and has been shown to exacerbate AD. This review attempted to elucidate the role of cytokines, growth factors, and associated mechanisms implicated in the course of AD, especially with neuroinflammation. We also evaluated the propensities and specific mechanism(s) of cytokines and growth factors impacting neuron upon apoptotic decline and further shed light on the availability and accessibility of cytokines across the blood-brain barrier and choroid plexus in AD pathophysiology. The pathogenic and the protective roles of macrophage migration and inhibitory factors, neurotrophic factors, hematopoietic-related growth factors, TAU phosphorylation, advanced glycation end products, complement system, and glial cells in AD and neuropsychiatric pathology were also discussed. Taken together, the emerging roles of these factors in AD pathology emphasize the importance of building novel strategies for an effective therapeutic/neuropsychiatric management of AD in clinics.
The practice of rating covered bonds
Authors: Mérő Katalin
Published: October 2021

This article analyses and compares the rating of covered bonds in the practice of the five credit rating companies which have 90% market coverage in the rating of European covered bonds (Moody’s, S&P, Fitch, DBRS and Scope). The rating of covered bonds tends to be excellent, it can even be significantly better than that of the issuing bank or that of the country in which the bank is located. The main reason for this are the different lines of defence laid down in regulation, which are also supported by the large-scale covered bond purchasing programme of the European Central Bank on the market’s side. The question is whether these lines of defence can really be deployed with full effectiveness in the event of significant turbulence in the real property market or a systemic banking crisis or a sovereign crisis, i.e. whether the current practice of the rating of covered bonds is not too optimistic.
Conclusion of an employment contract with the head of the organization
Authors: Krasnoyarova E.V.
Published: October 2021

The conclusion of an employment contract with the head of the organization differs to a certain extent from the registration of labor relations with an ordinary employee. In most cases, preliminary procedures are required. This article focuses on the emergence of labor relations with the heads of organizations of various organizational and legal forms and forms of ownership, considered certain problematic issues, including judicial practice, which makes it possible to make proposals for improving labor legislation.
Termination of the employment contract with the head of the organization
Authors: Krasnoyarova E.V.
Published: October 2021

The article examines the grounds for terminating the employment contract with the head of the organization, gives examples of judicial practice, reveals contradictions in the application of specific legal norms, and also makes proposals for improving labor legislation.
To the history of legal regulation of labor discipline and working hours (1923–1928)
Authors: Petrov A.Ya.
Published: October 2021

The article on the basis of an analysis of normative legal acts adopted from 1923 to 1928 considers topical legal issues of the institute of labor discipline and labor regulations in the Soviet state.
Mechanisms for the protection of social security rights of employees (part 2)
Authors: Averyanova M.I.
Published: October 2021

The subject of consideration was the mechanisms and methods of protecting the social security rights of employees. It was revealed that in the absence of a single systematizing act in the field of social security, provisions on mechanisms and methods of protection are contained in a large number of normative legal acts containing social security provisions. In some cases, these mechanisms are differentiated depending on certain factors: the type of social security, the characteristics of the labor status. Some of the control and supervisory protection mechanisms declared by the State are declarative, since they are not implemented in practice.
Dismissal of part-time employees on analysis of judicial practice
Authors: Dovgan K.E. , Gubernatorova E.V. , Kovalenko N.E.
Published: October 2021

The article analyzes the judicial practice on the dismissal of part-time employees. The ambiguity of the court’s positions determined the relevance of this research topic. Currently, there is an objective need for a detailed scientific study of the legal status of part-time employees and determining the grounds for their dismissal.
A fenntartható bankolás 10 pontja
Authors: Becsei András , Csányi Péter , Bógyi Attila , Kajtor-Wieland Ildikó , Kovács Levente
Published: October 2021

Az utóbbi évtizedekben egyre látványosabbá vált, hogy a bankrendszer mind intézményi működésében, mind a feladatai ellátása során elkötelezettebben kíván hozzájárulni a fenntarthatósági célok megvalósításához. Hazai kontextusban is láthatunk kezdeményezéseket, de szükséges lehet olyan, a fenntartható bankolás irányába mutató alapelvek lefektetése, amelyek rendszerszinten képesek erősíteni a bankszektor fenntarthatóságát és a bankok hozzájárulását a fenntarthatósági célok eléréséhez. A tanulmány egyrészt bemutatja a Magyar Bankszövetségnek a fenntartható banki működést támogató, 22 pontos digitalizációs javaslatcsomagjával kapcsolatos sikeres jogalkotási kezdeményezéseket, másrészt rámutat arra, hogy a hosszú távon fenntartható, versenyképes banki működést a jelenlegi folyamatok optimalizálásával, a hatékony és versenyképes adatgazdálkodással, valamint a zöldfinanszírozási aktivitás útján lehet elérni. Az ezek mentén megfogalmazott, egzaktabb lépésekkel pedig látványos előrelépés történhet a magyarországi bankrendszer fenntarthatóságának és fenntarthatósági hatásának erősítése terén.
Relapse of Lymphangioleiomyomatosis Five Years after Bilateral-Lung Transplantation
Authors: Heshmatnia Jalal , Mirenayat Maryam Sadat , Rezaei Mitrasadat , Bongomin Felix , Bakhshayeshkaram Mehrdad , Tabarsi Payam , Sheikhy Kambiz , Mortezaee Vida
Published: October 2021

Pulmonary lymphangioleiomyomatosis (LAM) is an uncommon disease principally affecting women during childbearing years and eventually leading to progressive respiratory failure. Lung transplantation is a viable option for patients with end-stage disease. LAM-related complications remain common, but recurrence of LAM following allograft transplantation is rare. We present a 25-year-old woman who presented with progressive dyspnea five years after bilateral lung transplantation for end-stage LAM. Histological examination of transbronchial lung biopsy sample confirmed recurrent LAM. We changed cyclosporine to sirolimus and she is currently being considered for re-transplantation.
Comparing the Effect of Dienogest and OCPS on Pain and Quality of Life in Women with Endometriosis: A Randomized, Double-Blind, Placebo-Controlled Trial
Authors: Niakan Gelareh , Rokhgireh Samaneh , Ebrahimpour Majid , Mehdizadeh Kashi Abolfazl
Published: October 2021

Background: Endometriosis is an estrogen-dependent disease that adversely affects women’s quality of life (QOL). We aimed to compare the effect of dienogest and oral contraceptive pills (OCPs) on pain and QOL in women with endometriosis. Methods: This randomized double-blind trial was conducted at Rasoul-e-Akram hospital, affiliated to Iran University of Medical Sciences, Tehran, Iran, from March 2018 to March 2020, on women with severe endometriosis confirmed by laparoscopic surgery. Ninety patients were randomly given either dienogest (Vissane 2 mg tablet; n = 30), or OCPs (LD; n = 30), or placebo (n = 30) daily for 12 weeks. The primary objective of this study was to evaluate the patient’s pain including dyspareunia, dysuria, dyschezia, and pelvic pain. The secondary outcome was considered as a change in patients’ QOL score. Results: The mean age of population was 32.99 ± 7.1 years. There was no significant difference in the three groups regarding baseline characteristics. Pelvic pain was significantly reduced, while the effect of medication on dysuria and dyschezia was not significant. The overall QOL score between the control and dienogest (P = 0.02) and OCPs groups (P = 0.001) was significantly different; however, the difference was not significant between the two intervention groups Conclusion: The finding of the present study revealed that there is no difference in the efficacy of dienogest and OCPs in management of pain and the QOL. But there was a significant difference between the placebo and intervention groups.
Epidemiological Study of Various HPV Strains in Cervical Fluid Samples in South-Eastern Iran, 2018–2020
Authors: Bahramabadi Reza , Honarvar Zahra , Iranpour Maryam , Kazemi Arababadi Mohammad , Dehesh Tania , Dabiri Bahram , Mortezaeizadeh Anari Abbas , Amirpour Rostami Sahar , Salajegheh Mohammad , Dabiri Shahriar
Published: October 2021

Background: Uterine cervical malignancy is one of the commonly detected malignancies related to the human papillomavirus (HPV) and is increasing incidentally in developing countries. Therefore, the use of an efficient diagnostic method is required as an effectual step for cervical cancer prevention and treatment. The purpose of the study was to diagnose various types of HPV in the cervical cytology specimens in the South-East of Iran. Methods: This cross-sectional study was performed on 1079 cervical fluid cytology specimens referred for two years, between 2018-2020. Polymerase chain reaction (PCR) and hybridization (INNO-LiPA HPV Genotyping EXTRA II assay) were used to determine HPV DNA and their genotypes, respectively. Results: HPV was positive in 37.7% (407 of 1079) patients with a mean age of 34.62 ± 8.82. Among positive cases, 252 (62%) had only one HPV genotype and 155 (38.05%) had multiplex HPV genotypes, which included 94 (60.7%), 38 (24.6%), 18 (11.6%) and 5 (3.2%) cases with two, three, four and five or more genotypes, respectively. The samples with multiple strains revealed 31 HPV genotypes with the four most prevalent being HPV6 (14.7%), HPV16 (10.9%), HPV53 (9.6%) and HPV51 (5.9%). Conclusion: HPV infection is the main health challenge for women that requires improved health service programs and appropriate epidemic vaccination.
Effect of different exercise trainings on β-cell function, insulin resistance, and osteocalcin levels in overweight men
Authors: Rostamizadeh Mehdi , Elmieh Alireza , Rahmani Nia Farhad
Published: October 2021

Background and aims: Many findings have shown the potential relation between osteocalcin (OCN) and regulating energy metabolism. In addition, it has been revealed that physical activity increases OCN levels. Therefore, the present study aimed to investigate the effects of different exercise trainings on β-cell function, insulin resistance, and OCN levels in overweight men. Methods: In this study, 33 overweight, young men [Body mass index (BMI): 29.32±0.75 and age range of 31.50±2.23] were randomly divided into control (n=11), aerobic exercise (n=11), and resistance exercise (n=11) groups. Participants of the exercise group were on the 8-week supervised exercise training program for three sessions per week. Weight, body fat percentage, and BMI were analyzed, and then OCN, insulin, and the homeostasis model assessment of insulin resistance (HOMA-IR) were assessed from fasting blood samples before and after the 8-week exercise program. Finally, data were analyzed by t test and analysis of covariance (ANCOVA). Results: Based on the results, BMI and body weight, insulin, glucose, and HOMA-IR reduced following the exercise (P<0.05) whereas serum OCN significantly increased in aerobic exercise (P=0.001) and resistance exercise (P=0.000) groups. There were no significant changes in β-cell function in aerobic exercise (P=0.512) and resistance exercise (P=0.16) groups. Pearson correlation analysis demonstrated that OCN levels were not correlated with HOMA-IR (P=0.743) and insulin levels (P=0.143). However, OCN was positively associated with the homeostasis model assessment of b-cell function (P=0.014) and glucose (P=0.025). Conclusion: The results of the present study confirmed that aerobic and resistance exercises cause some changes in body weight and BMI, as well as the OCN and HOMA-IR. Nonetheless, changes in OCN levels were not predictors of changes in insulin secretion from pancreatic beta cells.
Comparative effects of garlic (Allium sativum) powder and atorvastatin in female reproductive system of hypercholesterolemic rats: A histological and biochemical evaluation
Authors: Jafari Sima , Farokhi Farah , Sadeghi Abbas
Published: October 2021

Background and aims: The abnormal increase in blood cholesterol can cause many problems. Statins have a cholesterol-lowering effect, but they also have adverse effects. Garlic prevents the formation of cholesterol due to its antibiotic properties. This study aimed to investigate the comparative effect of garlic powder and atorvastatin on hypercholesterolemia-induced reproductive failure in female rats. Methods: In the present experimental study, 48 adult female Wistar rats were divided into eight groups (n=6), including control, atorvastatin (10 mg/kg/d; orally), atorvastatin (20 mg/kg/d; orally), garlic powder (100 mg/kg/d; orally), hypercholesterolemia (1.5 mg/kg/d of cholesterol; orally), hypercholesterolemia + atorvastatin (10 mg/kg/d), hypercholesterolemia + atorvastatin (20 mg/kg/d), and hypercholesterolemia + garlic powder. After 30 days, rats were euthanized and blood samples were obtained from their heart for serological assessments. The right ovary was transferred to 10% formalin for histological analyses, and the left ovary was transferred to a −80°C freezer for evaluation of oxidative stress markers. Data were statistically analyzed by ANOVA and Tukey’s test using SPSS version 24.0 (P<0.05). Results: The number of healthy primordial, primary, secondary, and antral follicles, catalase activity, total antioxidant capacity (TAOC) as well as estrogen and progesterone levels were lower in hypercholesterolemic rats compared to controls (P<0.001). Additionally, the number of the atretic primary, secondary, and antral follicles and malondialdehyde (MDA) levels were higher in hypercholesterolemic rats (P<0.001). However, garlic powder and atorvastatin 10 improved alterations in the mentioned parameters (P=0.99). Conclusion: The results showed that hypercholesterolemia could have adverse effects on rat ovaries. However, the garlic powder improves ovarian toxicity in hypercholesterolemia rats better than atorvastatin.
Effect of oral capsule of Peganum harmala seeds on bone density in menopausal women prone to osteoporosis
Authors: Keivani Hafshejani Zahra , Lorigooini Zahra , Deris Fatemeh , Akbari Neda , Farahbod Farinaz , Fazelian Siavash , Moradi Fatemeh , Dehghan Morteza
Published: October 2021

Background and aims: Osteoporosis is one of the most common metabolic bone diseases with systemic involvement of the body skeleton. The Peganum harmala seed contains high amounts of carboline alkaloids, which have been shown to have positive effects on bone formation in animal studies. In the present study, the effect of an oral capsule of P. harmala seed on bone density was evaluated in menopausal women prone to osteoporosis. Methods: In this randomized controlled clinical trial, 100 women referring to the orthopedic clinic with a diagnosis of osteoporosis were included and divided into the intervention group treated with calcium D (500 mg) twice a day, Osteofos (70 mg) per week, and P. harmala (500 mg) twice‐a‐day, and the control group treated with calcium D and Osteofos. Before and three months after the intervention, patients were evaluated for osteoporosis using bone densitometry. Finally, independent t-test, paired t-test, and repeated measures ANOVA were used for statistical analysis. Results: The mean bone mineral density (BMD) of the femur before and after the intervention showed significant improvements in the intervention and control groups (P<0.001). The mean differences in BMD before and after the intervention were significant in both control and intervention groups with higher improvements in the intervention group (P<0.001). Although the mean BMD of the spine before the intervention was not significantly different between the two groups (P=0.167), it was better in the intervention group after the intervention (P=0.030). Conclusion: The findings of the present study confirmed the beneficial effects of P. harmala on osteoporosis while the lack of any changes in liver enzymes.
Tromboembolismo pulmonar:
Authors: Jiménez Sánchez Natalia
Published: October 2021

El tromboembolismo pulmonar (TEP) representa un continuo de la enfermedad tromboembólica, con diversos factores de riesgo, la mayoría de ellos adquiridos. Sus manifestaciones clínicas son varias, pero por lo general corresponden a signos y síntomas respiratorios en su mayoría, así como cardíacos. Siendo esta una patología de presentación amplia y frecuentemente pasada por alto, este trabajo se centra en una descripción sistematizada del trabajo diagnóstico y manejo del TEP.
Definición y manejo inicial del Trauma craneoencefálico leve
Authors: Watson Hernandez Rebeca Alina , Soto Rodríguez Rebeca
Published: October 2021

El trauma craneoencefálico es una de las consultas más frecuentes del Servicio de Emergencias, este se divide en leve, moderado y severo según la escala de Glasgow, siin embargo, predomina el trauma leve.  Los principales síntomas suelen ser pérdida de consciencia, bradipsiquia y amnesia. Estos pueden persistir por un par de días en lo que se conoce como Síndrome Posconmocional. No todo paciente con TCE leve amerita estudios de imagen, ya que esto sería una exposición innecesaria a la radiación y se daría un uso inadecuado a esta herramienta tan importante.
Incidencia de streptococcus agalactiae en mujeres gestantes de las áreas de salud Goicoechea 1 y Goicoechea 2
Authors: Madrigal Vega Alberto
Published: October 2021

Streptococcus agalactiae es un coco Gram positivo que forma parte de la microbiota normal del tracto gastrointestinal y genitourinario humano. La colonización por este patógeno posee gran relevancia en el caso de las mujeres embarazadas, debido al riesgo de transmisión hacia el neonato, ya que puede ocasionarle diversas patologías, tales como, sepsis, meningitis y muerte. El diagnóstico oportuno de este microrganismo mediante un hisopado vaginal-anal, tomado entre las semanas 35 y 37 de gestación, y la utilización de medios de cultivo específicos (como caldo Todd-Hewitt, agar sangre o agar cromogénico) permite dar un tratamiento profiláctico a la madre antes o durante el parto, con el fin de prevenir los eventuales daños en el neonato.
Cáncer de piel:
Authors: Ureña Vargas María José , Sánchez Carballo Reiner , Kivers Bruno Gabriel , Cerdas Soto Diego , Fernández Angulo Verónica
Published: October 2021

El cáncer cutáneo puede dividirse en melanoma y los no melanomas, carcinoma epidermoide y basocelular. Es importante reconocerlos debido al aumento en su incidencia y de esta forma lograr un adecuado tratamiento.
Manejo clínico y radiológico para la detección temprana en la displasia del desarrollo de la cadera
Authors: Fernández Angulo Verónica , Cerdas Soto Diego , Ureña Vargas María José , Sánchez Carballo Reiner , Kivers Bruno Gabriel
Published: October 2021

La displasia del desarrollo de cadera se logra sospechar, al realizar una examinación física completa e historia clínica, donde se pueden obtener signos e historia familiar importante que me indiquen algunos factores de riesgo. Una vez obtenidos estos resultados, se inicia el protocolo de la DDC. Entre más temprano se detecte esta patología, más rápido se inicia el tratamiento y menos secuelas a largo plazo presentan los niños. El método radiológico más efectivo hasta el momento, para el diagnostico de la DDC, es el ultrasonido en <3 meses y radiografías en >3 meses de edad.
Studies and Research on the Influence of Deposit Parameters on the Characteristics of Composite Coatings Ni-Al2O3 Obtained by Electrochemical Methods
Authors: BOICIUC Simona
Published: October 2021

The paper presents the characterization of composite coatings with nickel matrix using as dispersed phases Al2O3 particles, both from the microstructural point of view and from the point of view of the layer thickness, micro-hardness and corrosion behavior in saline fog. The presence of dispersed phase particles led to the finishing of the structure because they acted as nucleus centres, reducing the size of nickel crystallites. The parameters of the deposits influence the structure and properties of the obtained layers.
Application of the Natural Cellulosic Supports for the Treatment of the Industrial Effluents
Authors: BONDAREV Andreea
Published: October 2021

Wastewater treatment is one of the most important concerns of the research studies in the field of environmental protection. The current study relates to the removal of Crystal violet dye from aqueous solutions through adsorption experiments onto natural cellulosic supports.

Various waste materials that have in their composition lignocellulose are adsorbent supports with low costs for the removal of heavy metal ions and dyes from aqueous solutions.

The use of chemically modified sawdust to obtain an inexpensive adsorbent for removing the Crystal violet dye (CV) from synthetic aqueous solutions has been presented in this research paper. The influence of some important parameters such as: initial dye concentration, adsorbent dose, contact time and temperature on adsorption efficiency for this dye removal have been studied. The Freundlich, Langmuir and Temkin mathematical models have been used to evaluate the data of Crystal violet adsorption from aqueous media using wood sawdust.

The research study shows that beech wood sawdust (Fagus sylvatica), as an agricultural waste which is readily available and relatively inexpensive has the potential to be an applicable alternative adsorbent for Crystal violet dye removal from industrial effluents.
PREVALENCE OF MALNUTRITION/MALNUTRITION RISK AND RELEVANT FACTORS AMONG OLDER ADULTS
Authors: Eken Kübra , Uyar Mehmet
Published: October 2021

This study aimed to assess the prevalence of malnutrition and malnutrition risk of older adults, and identify socio-demographic and medical characteristics that affect the nutritional status of older adults in Konya city centrum. This cross-sectional study was conducted between April and July. Sociodemographic characteristics and medical history questionnaire prepared by researcher, Mini Nutritional Assessment (MNA) and Geriatric Depression Scale (GDS) and Mini-Mental State Examination (MMSE) in order to answer objectively depression and cognitive disorder questions in MNA were applied with face-to-face interview method. A total of 276 individuals were included in the study. According to the MNA, malnutrition/malnutrition risk was found 39.5%, and 60.5% of the participants were found to have good nutritional status. In those who have at least one chronic disease, use at least one drug regularly, have 'depression' according to GDS, and have cognitive impairment according to MMSE, malnutrition and the risk of malnutrition were significantly higher. In conclusion, A significant proportion of the elderly was found to have malnutrition and malnutrition risk, and those with cognitive impairment and depression had a higher ratio of malnutrition and risk of malnutrition.
CLINICAL AND EPIDEMIOLOGICAL CHARACTERISTICS OF CUTANEOUS LEISHMANIASIS CASES IN ISTANBUL
Authors: Yakşi Neşe , İkiışık Hatice , Güner Abdullah Emre , Maral Işıl
Published: October 2021

Cutaneous leishmaniasis (CL) is a vector-borne disease characterized by skin lesions healing with an atrophic scar. Istanbul is a high-risk province for CL due to internal and international immigrants. The aim of this study is to determine the clinical and epidemiological characteristics of CL cases in Istanbul. In this descriptive study, we evaluated the Cutaneous leishmaniasis cases in Istanbul between June 1st, 2014 and May 31st, 2015. The ethics committee and instutional permissions were received. Frequency analysis were used for data analysis. The study was carried out with 197 CL cases. Percentage of patients under 18 years old was 52%. Seventy-seven percent of cases were Syrian and most of them had no passports. Household average number was six. Percentage of individuals with a CL lesion at household in the last year was 23%. Sixteen percent of cases reported a recent visit to Southeastern Anatolia and 55% of them reported that the lesions appeared after the visit. About half of cases had more than one lesion. Face (43.7%) was the most commonly affected. The lesions of 74 cases (38%) appeared before living in Istanbul. Health Directorates of the districts where Syrian immigrants live in Istanbul should screen Syrian immigrants in terms of CL periodically. Also improving living conditions, drying of stagnant water areas, use of mosquito nets, wearing long-sleeved clothes, diagnosis, and effective treatment of CL are recommended methods for CL control.
BOLU İL MERKEZİNDE GENÇLİK VE SPOR BAKANLIĞINA BAĞLI YURTLARDA KALAN ÜNİVERSİTE ÖĞRENCİLERİNİN BESLENME BİLGİ DÜZEYİNİN VE OBEZİTE/FAZLA KİLOLULUK SIKLIĞININ DEĞERLENDİRİLMESİ
Authors: Albayrak Yaman Zeynep , Ünal Egemen
Published: October 2021

Çalışmamızın amacı yurtlarda kalan üniversite öğrencilerinin beslenme durumu ve alışkanlıklarını, beslenme bilgi düzeyini ve obezite/fazla kiloluluk sıklığını saptamaktır. Çalışma, Bolu il merkezinde Aralık 2020-Şubat 2021 tarihleri arasında, Gençlik ve Spor Bakanlığı’na bağlı yurtlarda barınan üniversite öğrencilerinde gerçekleştirilen kesitsel tipte bir çalışmadır. Çalışma 309 öğrencinin katılımıyla gerçekleştirilmiştir. Araştırmada veri toplama aracı olarak, genel bilgileri, sağlık bilgilerini, beslenme ve tüketim alışkanlıklarına ait soruları, fiziksel aktivite formunu, antropometrik ölçümleri, besin tüketim sıklığı formunu, Yetişkinler İçin Beslenme Bilgi Düzeyi Ölçeği’ni (YETBİD) içeren anket formu uygulanmıştır. Öğrencilerin yaş ortalaması 21,3±1,7 yıl olup %50,8’i kadındır. Bireylerin %69,6’sı normal, %23,0’ı fazla kilolu/obez ve %7,4’ü zayıftır. Öğrencilerin çoğu (%75,7) sağlık/beslenmeyle ilgili ders almamıştır. Katılımcıların %55’inin ana öğün atladığı, öğrencilerde en fazla atlanan öğünün öğle, en az atlanan öğünün akşam öğünü olduğu belirlenmiştir. Üst sınıflara gidildikçe öğrencilerin akşam yemeğini dışarda yeme sıklığının arttığı saptanmıştır. Kız öğrencilerin temel beslenme ve besin tercihi puanı erkek öğrencilerden yüksek bulunmuştur. Öğrencilerin BKİ (Beden Kitle İndeksi) gruplarına göre beslenme bilgi düzeyleri arasında bir fark bulunamamıştır. Son sınıflarda okuyan öğrencilerin temel beslenme ve besin tercihi puanları ilk sınıflarda okuyan öğrencilere göre yüksek bulunmuştur. Beslenme/sağlık ile ilgili ders alan öğrencilerin besin tercihi puanının daha yüksek olduğu saptanmıştır. Son sınıflarda okuyan öğrencilerin beslenme bilgi düzeyinin daha yüksek olmasına rağmen sınıf düzeyi arttıkça dışarda yeme sıklığının da arttığı görülmektedir. Dolayısıyla bireylerin yeterli bilgi düzeyine sahip olması kadar bilgiyi davranış biçimine dönüştürmesi ve sağlıklı beslenme alışkanlıkları kazanması da bir o kadar önemlidir. Belirli sürelerde yurtlarda kalan öğrencilerin beslenme alışkanlıkları zaman içerisinde değişebilmektedir. Bu yüzden öğrencilere günlük hayatta doğru besin tercihi yapma, yeterli ve dengeli beslenme, fiziksel aktivite konularında farkındalıklarının artırılması için düzenli eğitimler verilmesi ve öğrencilerin bu anlamda yurtlarda takip edilmeleri yararlı olacaktır.
PENGUJIAN DIMENSI CAUSE- RELATED MARKETING (CRM) TERHADAP LOYALITAS PRODUK AIR MINUM DALAM KEMASAN MEREK AQUA (STUDI PADA MAHASISWA UNIVERSITAS BORNEO TARAKAN)
Authors: Aisyah Siti , Syahran Syahran
Published: October 2021

Penelitian ini membahas mengenai Pengujian dimensi Cause Related Marketing (CRM) terhadap loyalitas air minum dalam kemasan merek AQUA. Desain penelitian yang digunakan didasarkan oleh penelitian Douwe van de Brink, Gaby Odekerken-Schroder dan Pieter Pauwels (2006). Pengujian variabel independen Cause Related Marketing (CRM) yang diukur melalui empat buah dimensi yakni congruency, duration, amount of resources invested dan executive management involvement dan satu variabel dependen adalah loyalitas merek. Penelitian ini adalah penelitian kuantitatif di mana data primer dikumpulkan melalui angket atau kuesioner yang disebar kepada 263 responden yang mengkonsumsi air minum dalam kemasan merek AQUA dan juga mengetahui iklan “Satu Untuk Sepuluh” di Universitas Borneo Tarakan. Hasil penelitian menunjukkan bahwa Variabel Cause Related Marketing (CRM). Hasil analisis regresi dari variabel CRM menunjukkan tidak semua dimensi bepengaruh positif dan juga signifikan terhadap loyalitas merek. Dari keempat dimensi yaitu congruency, duration, amount of resources invested dan executive management involvement hanya duration, amount of resources invested yang berpengaruh positif dan signifikan terhadap loyalitas merek. Dari semua faktor yang membuat kampanye CRM sukses adalah lamanya waktu kampanye dan sumber daya yang di investasikan.
PENGARUH VARIABEL MAKRO DAN HARGA KOMODITAS TAMBANG TERHADAP HARGA SAHAM SEKTOR PERTAMBANGAN DI INDEKS SAHAM SYARIAH INDONESIA (ISSI)
Authors: Artiani Listya Endang , Utami Puspita Sari Citra
Published: October 2021

Abstrak: Penelitian ini menjelaskan pengaruh variabel makroekonomi yaitu inflasi dan kurs rupiah dan harga komoditas tambang yaitu harga minyak mentah dunia dan harga batubara dunia dalam mempengaruhi harga saham sektor pertambangan di Indeks Saham Syariah Indonesia (ISSI). Data yang digunakan ialah data sekunder dengan menggunakan analisis data panel.Hasil analisis data dengan menunjukkan bahwa variabel inflasi memiliki pengaruh signifikan negatif, kurs rupiah terhadap dolar AS tidak memiliki pengaruh signifikan, harga minyak mentah dunia memiliki pengaruh positif, dan harga batubara dunia memiliki pengaruh signifikan positif. Secara simultan keempat variabel memiliki pengaruh yang signifikan, sedangkan secara parsial hanya kurs rupiah terhadap dolar AS tidak memiliki pengaruh yang signifikan terhadap harga saham sektor pertambangan di Indeks Saham Syariah Indonesia (ISSI).
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI PERILAKU KONSUMEN DALAM PENGAMBILAN KEPUTUSAN PEMBELIAN PRODUK ROTI ISI KRIM DURIAN (JORDAN BAKERY) DI DESA RANTAU SIALANG KECAMATAN SUNGAI KERUH
Authors: Mindari Ellisyah
Published: October 2021

Penelitian ini bertujuan untuk untuk menganalisa faktor-faktor yang mempengaruhi perilaku konsumen dalam pengambilan keputusan pembelian. Penelitian ini menggunakan pendekatan kuantitatif. Dalam penarikan sampel yang peneliti lakukan dengan menggunakan rumus slovin. Sampel dalam penelitian ini adalah warga Desa Rantau Sialang dengan jumlah responden sebanyak 97 orang. Metode analisis dengan menggunakan alat analisis dengan bantuan program IBM SPSS Statistics 24. Hasil penelitian ini menunjukan bahwa ada pengaruh yang positif dan signifikan faktor budaya, faktor sosial, faktor pribadi dan faktor psikologis secara bersama-sama terhadap keputusan pembelian dengan nilai Fhitung (146,337) Ftabel (2,471) dan nilai signifikan 0,000. Selanjutnya berdasarkan hasil uji t untuk variabel faktor budaya (X1) diperoleh nilai thitung (-0,119) nilai ttabel (-1,985), nilai signifikan t sebesar 0,905 nilai α (0,05), sehingga dapat disimpulkan bahwa faktor budaya (X1) secara parsial tidak berpengaruh secara signifikan terhadap keputusan pembelian (Y). Sementara itu, variabel faktor sosial (X2) diperoleh nilai thitung (4,771) nilai ttabel (1,985) dan nilai signifikan t sebesar 0,000 nilai α (0,05); variabel faktor pribadi (X3) diperoleh nilai thitung (10,631) nilai ttabel (1,985) dan nilai signifikan t sebesar 0,000 nilai α (0,05); variabel faktor psikologis (X4) diperoleh nilai thitung (-2,713) nilai ttabel (-1,985) dan nilai signifikan t sebesar 0,008 nilai α (0,05).  Dengan hasil tersebut berarti bahwa faktor sosial (X2), faktor pribadi (X3) dan faktor psikologis (X4) secara parsial berpengaruh secara signifikan terhadap keputusan pembelian (Y).  Kata kunci: Budaya, Sosial, Pribadi, Psikologis dan Keputusan Pembelian.
STRATEGI PEMASARAN TERHADAP IMPULSE BUYING (Penelitian Pada Konsumen Sinar Terang Bersaudara)
Authors: Hasanah Nurjannatul , Arifudin Arifudin
Published: October 2021

Penelitian ini bertujuan untuk mengetahui pengaruh suasana toko,potongan harga, dan tenaga penjual terhadap pembelian impulsif (penelitian pada konsumen di Supermarket Sinar Terang Bersaudara). Penelitian ini menggunakan pendekatan kuantitatif dengan metode survei. Metode pengambilan sampel yang digunakan adalah teknik nonprobability sampling dengan menggunakan sampel purposive sampling. Sampel dalam penelitian ini adalah masyarakat Kota Tarakan yang pernah berbelanja di toko Terang Sinar Bersaudara dengan jumlah sampel 100 orang. Metode analisis yang digunakan adalah analisis regresi dengan bantuan program SPSS versi 22. Hasil penelitian ini menunjukkan bahwa variabel suasana berpengaruh positif dan signifikan terhadap pembelian impulsif. Sedangkan variabel diskon dan tenaga penjual tidak berpengaruh dan signifikan terhadap pembelian impulsif.
PROSPEK DAN KONTRIBUSI KOMODITAS PADI (Oriza sativa) TERHADAP PDRB SEKTOR PERTANIAN DI PROVINSI KALIMANTAN UTARA, INDONESIA
Authors: Machmuddin Nurlela , Khaerunnisa Khaerunnisa , Liko Emilianus
Published: October 2021

Kalimantan Utara sebagai salah satu provinsi baru dan berada langsung di wilayah perbatasan dituntut untuk dapat mengembangkan sumberdaya alam yang dimiliki secara optimal utamanya di sektor pertanian dalam hal pemenuhan pangan beras yang semakin meningkat dan diharapkan dapat menjadi wilayah penyangga pangan untuk ibu kota baru nantinya.  Besar kecilnya produksi padi akan berpengaruh terhadap ketersediaan padi atau beras dan secara tidak langsung juga berdampak pada  kontribusinya terhadap Produk Domestik Regional Bruto (PDRB). Penelitian ini bertujuan untuk  mengetahui  prospek perkembangan komoditas padi di Provisi Kalimantan Utara ditinjau dari produksi, luas panen dan produktivitasnya; dan menganalisis kontribusi subsektor tanaman pangan terhadap PDRB bidang usaha pertanian, peternakan, perburuan dan jasa di Provisi Kalimantan Utara. Metode analisis yang digunakan adalah deskriptif kualitatif dengan pendekatan review literature dan penelusuran data sekunder berupa jenis data time series periode tahun 2013-2018. Analisis trend linier dan rumus proporsi digunakan Untuk mengetahui prospek dan kontribusi. Hasil analisis trend menunjukkan bahwa produksi padi cenderung mengalami trend penurunan yang diakibatkan olah trend penurunan luas panen, sedangkan produktivitasnya cenderung mengalami pelandaian (levelling off). Hal ini menunjukkan bahwa komoditas padi belum mampu dijadikan sebagai sektor unggulan di provinsi Kalimantan Utara. 2) kontribusi subsektor tanaman pangan terhadap PDRB bidang usaha pertanian, peternakan, perbutuan dan jasa di Provisi Kalimantan Utara sebesar 11.94 persen di bawah rata-rata kontribusi di sektor tersebut (15.09 persen) sehingga dapat disimpulkan bahwa Provinsi Kalimantan Utara belum bisa mengandalkan sub sektor tanaman pangan untuk peningkatan PDRB. Kata kunci: Padi, PDRB, Sektor Pertanian