bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of СD4+CD8+ double-positive T cell subpopulations in the patients with immunodeficiencies
Authors: Aktanova A. A. , Boeva O. S. , Skribacheva E. O. , Skachkov I. P. , Pronkina N. V. , Meledina I. V. , Zheltova O. I. , Krugleeva O. L. , Kozlov V. A.
Published: February 2025

Until recently, the studies of pathogenetic mechanisms of different diseases were focused on evaluation of the major cell populations, changes in their quantitative and qualitative characteristics, such as gene expression profile, secreted factors, surface markers, etc. Nowadays, the minor cell subpopulations, their low amounts in peripheral blood are of considerable interest. These cells may function in variable ways, by polarizing the immune response, or participating in regulation of the immune reactions. One of such minor subpopulations is presented by CD4+CD8+ double-positive T lymphocytes which comprise up to 3%, of blood lymphocyte contents. However, these cells are a predominant subpopulation among all T cells in thymus (about 75%). Peripheral double-positive T lymphocytes are a special subpopulation of T cells, because they have no markers characteristic of immature T cells of the thymus, but they bear memory cells antigens, e.g., the CD1a molecule, and a reduced amount of TREC, thus indicating a differentiated mature phenotype. At the same time, these cells may have different phenotypes and functions performed by them. However, the role of CD4+CD8+ double-positive T lymphocytes have not been well studied. There are positive correlations between an increase in double-positive T lymphocytes and demographic and anthropomorphological characteristics, such as age, gender, body mass index. It is known that the contents of this cell subpopulation increase in various pathological conditions, for example, in mononucleosis caused by the Epstein-Barr virus, cytomegalovirus, human immunodeficiency virus, hepatitis C, hemorrhagic fever virus, like as in oncological, autoimmune and allergic diseases. Thus, the peripheral CD4+CD8+T cells are assumed to play an important role in regulating immune responses under pathological conditions. We assessed the relative number of CD4+CD8+ double-positive T lymphocytes in immunodeficiencies in different groups depending on age, gender, and certain diagnostic markers, i.e., detection of Staphylococcus aureus, vitamin D deficiency, intestinal or mixed giardiasis, a positive PCR result for a viral infection, and the status of a COVID-19 reconvalescence. We obtained a statistically significant increase of of CD4+CD8+T cell numbers in both men and women, and the number of cells was also changed depending on age, but the selected criteria did not reflect the numerical changes of these cells. A more detailed study on the role of double-positive T lymphocyte subpopulations is necessary, both in immune disorders, and under normal health conditions, because CD4+CD8+ double-positive T lymphocytes can be a significant tool of immune response regulation and sustainability of immunity.
Hormone-producing role of mast cells in reproductive processes: myth or reality?
Authors: Valikova O. V. , Zdor V. V. , Tikhonov Ya. N. , Boroda A. V.
Published: February 2025

The role of mast cells in the onset and progression of endocrine system dysfunction has been studied for quite a long time, but a clear understanding of their participation has not been obtained. The purpose of the study was to consider the hormone-producing and cytokine-producing functions of mast cells in primary culture in various environments simulating certain hormonal conditions, modeling the level of hormones in follicular fluid during ovulation, to identify the participation of mast cells in the development of endocrine diseases, and to discover new functions of mast cells.
A continuous line of human mast cells HMC-1 (Human mast cell, ATCC) was used, being cultured in IMDM medium (Dulbecco’s modified Eagle’s medium, Sigma-Aldrich). Medium 1 (IMDM) served as a control; medium 2 was an IMDM medium supplied with hormones simulating follicular fluid during ovulation in healthy women, and medium 3 (IMDM) was supplied with hormones mimicking follicular fluid during ovulation in polycystic ovary syndrome. The content of progesterone, testosterone, estradiol, IL-6 was measured on days 1,3,7 of experimental cultures.
Hormonal pattern in the mast cell cultures changed depending on the microenvironment and duration of experiment. The level of estradiol in medium 1 increased more than 80 times compared to the level of estradiol before initiation the cultures. Incubation in medium 2 was followed by 40-fold increase in estradiol by the 7th day of experiment. In medium 3, estradiol levels increased more than 35 times. Testosterone level increased in medium 1 by 3 times; in medium 2, 2.5-fold by the day 7. Upon culture in medium 3, testosterone levels increased 8-fold. IL-6 levels in all media with mast cell culture increased by day 7, but did not exceed the physiological ranges of the cytokine.
A significant progressive increase in the contents of estradiol, testosterone and IL-6 in continuous culture of HMC-1 mast cells observed in different culture media simulating certain in vivo hormonal background suggests an active participation of mast cells in reproductive processes and an independent de novo synthesis of sex steroids and IL-6 by mast cells, which, however, requires a number of confirmatory experiments.
CD44 expression level on different cell lines of hematopoietic origin
Authors: Pashkina E. A. , Bykova M. V. , Berishvili M. T. , Krugleeva O. L.
Published: February 2025

CD44 is a hyaluronic acid receptor, a surface molecule expressed on many cells in human body that is essential for some processes, such as cell adhesion and migration. Therefore, this molecule also plays an important role in various aspects of tumor growth, metastasis and invasive processes. High levels of CD44 expression have been found on tumor cells from patients with hematological malignancies, and there is a direct link between CD44 levels and the likelihood of relapse, as well as a dismal prognosis in most hematological malignancies. The purpose of this study was to determine the level of CD44 expression on the surface of tumor cells, namely cell lines of hematopoietic origin.
The expression of CD44 on cell lines 1301 (T cell lymphoma) and K562 (erythromyeloid leukemia) was assessed by flow cytometry.
It was demonstrated that the both cell lines are capable of expressing the CD44 molecule on their surface. In the case of erythromyeloid leukemia cell line K562, a low level of expression of this receptor was observed, while in the case of the T cell lymphoma cell line 1301, the vast majority of cells showed high level of CD44 expression.
In general, the level of expression of this receptor on tumor cells in the case of hematological malignancies may be quite variable in different cell lines of hematopoietic origin.
Detection of allergen-specific Th2A-cells in peripheral blood of patients with allergic diseases
Authors: Blinova E. A. , Leonova M. I. , Nepomnyaschikh V. M. , Demina D. V.
Published: February 2025

There is an increase in the incidence of allergic diseases all over the world including Russia. The most common allergic disorders are allergic rhinitis, atopic dermatitis and bronchial asthma. Despite the differences in symptoms, the pathogenesis of all allergic diseases is based on activation of the Th2 immune response. A heterogeneous population of CD4+ lymphocytes is developed in response to allergen. Recently, a group of researchers described a population of terminally differentiated allergen-specific T cells that co-express CRTh2, CD161, and produced high levels of IL-5 and IL-9. This population was called pro-allergic “Th2A” cells. The aim of the present work was to assess the contents of allergen-specific Th2A cells and Th2 lymphocytes in allergic bronchial asthma, atopic dermatitis and allergic rhinitis. The study included 10 patients with allergic rhinitis, 9 cases of atopic dermatitis, 12 patients with allergic bronchial asthma and 8 healthy individuals. Phenotyping of Th2A cells (CD4+CD45RO+CD27-CRTh2+CD161+) and Th2 lymphocytes (CD4+CD45RO+CRTh2+) from mononuclear cells of peripheral blood was performed by flow cytometry. There were no significant differences in the number of Th2 lymphocytes, either between the donor’s group and all groups of patients with allergic diseases, or between groups of patients with different allergic diseases. A 3- to 4-fold increase in the number of Th2A cells compared to healthy individuals was observed in groups of patients with allergic rhinitis, atopic dermatitis, and a 2-fold increase was found in the group of patients with bronchial asthma. Moreover, the level of allergen-specific Th2A cells in patients with allergic rhinitis and in atopic dermatitis was significantly higher than in patients with bronchial asthma. This finding reflects probable involvement of Th2A cells in the pathogenesis of allergic diseases. Th2A cells may be also considered as a potential marker for tracing the course of allergic disease and assessing the efficiency of therapy, thus requiring further research in the field.
Mitochondrial uncoupling, a new element in pathogenesis of metabolic syndrome: a pilot study
Authors: Voronova S. S. , Bograya M. M. , Vulf M. A. , Gorbacheva A. M. , Gazatova N. D. , Kuznetsov G. L. , Litvinova L. S.
Published: February 2025

Obesity and insulin resistance are the main factors in development of metabolic syndrome (MetS). In patients with MetS, there is an active accumulation of free fatty acids in the liver, which may lead to disturbances in homeostasis and metabolism of hepatocytes, thus resulting in mitochondrial dysfunction, oxidative stress, and cellular apoptosis. Mitochondrial dysfunction has been extensively studied in the context of pathogenetic features of metabolic syndrome. However, the processes of mitochondrial uncoupling remain unclear. Mitochondrial uncoupling (MU) is a process associated with a decrease in ATP synthesis and reactive oxygen species (ROS) in mitochondria. It is mediated by proteins from the UCP (uncoupling proteins) family, as well as ANT (ADP/ATP translocase). “Mild” MU is necessary for maintaining normal mitochondrial function, whereas “severe” MU may lead to mitochondrial dysfunction. Thus, the aim of the present study was to investigate the expression levels of SIRT1 V1 deacetylase, transcription factors PGC-1α, PPAR-α, PPAR-γ that stimulate lipogenesis and β-oxidation of FFAs, and expression of some genes encoding mitochondrial uncouplers ANT2 and UCP2 in the liver of patients with MetS. The study included two groups, as follows: patients with MetS (inclusion criteria: BMI 30 kg/m2, along with type 2 diabetes and/or fasting blood glucose 5.5 mmol/L), and a control group (BMI 30 kg/m2, absence of infectious and chronic diseases). Biochemical analysis of blood parameters was conducted using the Furuno CA-180 biochemical analyzer (Furuno Electric Company, Japan) with DiaSys test systems (DiaSys Diagnostic Systems, Holzheim, Germany). The expression levels of the genes of interest in liver biopsies were assessed using quantitative RT-PCR with SYBR Green (Evrogen, Russia).
In patients with MetS, a significant increase (compared to the control group) in expression level of the PPAR-γ transcription factor was found, being associated with de novo lipogenesis in the liver, as well as increased expression of mitochondrial ANT2 uncoupler gene. Expression levels of other genes (SIRT1 V1, PGC-1α, PPAR-α, UCP2) measured in liver biopsies from the patients with MetS did not show significant changes. An increased expression of the ANT2 gene in MetS patients may be related to both compensatory protective mechanisms, e.g., activation of “mild” MU, and pathological processes resulting from “strong” MU. Further studies are needed to investigate the effects of ANT2 and UCP2 on the cellular metabolism (ATP production, ROS generation, development of oxidative stress), both directly in human liver tissue, and in cell cultures. This article presents for the first time the results concerning expression of mitochondrial uncoupler genes (ANT2, UCP2) in the liver of patients with MetS.
Evaluation of endemic Bet v 1 allergen spectrum at the territory of the Republic of Belarus
Authors: Parkhomchuk O. Yu. , Fomina E. G. , Grigorieva E. E.
Published: February 2025

The birch tree occupies the temperate climate region in North America and Europe. Every year between April and May, the birch trees pollinate intensively, which is a common cause of seasonal pollinosis which negatively affects the quality of life in many subjects. Pollen allergy (pollinosis) is among the leading allergic diseases. Sensitization to birch pollen is common in the European regions. Bet v 1 is the main birch pollen allergen which may induce specific IgE in 95% of patients sensitized with birch pollen. Bet v 1 belongs to the PR-10 class of proteins, which includes a large group of aeroallergens and common food allergens. Currently, according to the nomenclature of allergens, 27 variants (isoforms) of Bet v 1 proteins are discerned which may often differ in only several amino acids. The aim of this study was to determine the genetic diversity of the major birch pollen allergen Bet v 1 on the territory of the Republic of Belarus. We studied the pollen samples from birch collected in spring time. Recombinant vector constructs containing genes encoding different isoforms of Bet v 1 allergen were obtained. The nucleotide sequences of the cloned fragments have been determined. Three sequences were found to contain intronic regions interrupting the coding part of the gene. An abridged reading frame was detected in two other sequences. We evaluated the spectrum of Bet v 1 protein isoforms. The sequences obtained are related to 11 genetic variants of the studied allergen to a greater or lesser extent. The majority (86%) of the identified variants correspond to 7 isoforms of 2 isoallergens retrieved in the database of allergenic proteins, with Bet v 1.0101-like sequences being more common (42%), followed by the group with common Bet v 1.0104 variant (19%). The third position (11%) is occupied by Bet v 1.0102-like sequences. The Bet v 1.02 isoallergen is represented by a single variant which is closely similar to the Bet v 1.0204 isoform (3% of the total number of sequences under study). 7 Bet v 1 isoforms were identified within one phylogenetic tree. Bet v 1.0101 (Bet v 1a, X15877.1) was found to be the predominant isoform of the main birch pollen Bet v 1 allergen.
Makespan Trade-offs for Visiting Triangle Edges
Authors: Georgiou Konstantinos , Kundu Somnath , Pralat Pawel
Published: February 2025

We study a primitive vehicle routing-type problem in which a fleet of $n$unit speed robots start from a point within a non-obtuse triangle $\Delta$, where $n \in \{1,2,3\}$. The goal is to design robots' trajectories so as to visit all edges of the triangle with the smallest visitation time makespan. We begin our study by introducing a framework for subdividing $\Delta$into regions with respect to the type of optimal trajectory that each point $P$ admits, pertaining to the order that edges are visited and to how the cost of the minimum makespan $R_n(P)$ is determined, for $n\in \{1,2,3\}$. These subdivisions are the starting points for our main result, which is to study makespan trade-offs with respect to the size of the fleet. In particular, we define $ R_{n,m} (\Delta)= \max_{P \in \Delta} R_n(P)/R_m(P)$, and we prove that, over all non-obtuse triangles $\Delta$: (i) $R_{1,3}(\Delta)$ ranges from $\sqrt{10}$ to $4$, (ii) $R_{2,3}(\Delta)$ ranges from $\sqrt{2}$ to $2$, and (iii) $R_{1,2}(\Delta)$ ranges from $5/2$ to $3$. In every case, we pinpoint the starting points within every triangle $\Delta$ that maximize $R_{n,m} (\Delta)$, as well as we identify the triangles that determine all $\inf_\Delta R_{n,m}(\Delta)$ and $\sup_\Delta R_{n,m}(\Delta)$ over the set of non-obtuse triangles.

Comment: 47 pages, 27 figures
17 Unterrichtsreihen, die funktionieren
Authors: van Norden Jörg
Published: February 2025

Jörg van Norden entwickelt in diesem Band 17 Unterrichtsreihen, die den Stoff der Sekundarstufe I fast vollständig abdecken. Die Reihen berücksichtigen dabei zentrale Kriterien guten Geschichtsunterrichts: Lebensweltbezug, Perspektivität, Chronologie und Narrativität. Ihre Verlaufspläne sind jeweils mit Bildern hinterlegt, die als Aufhänger für die einzelnen Unterrichtseinheiten dienen. Hinzu kommt ein Zeitlineal, das die Planung transparent macht und im Unterricht als Lerntagebuch eingesetzt werden kann.
Pengaruh Rasio Pemijahan yang Berbeda Terhadap Jumlah Natalitas Larva Ikan Molly Balon (Poecilia latipinna sailfin molly)
Authors: Hadi Gilang Wisnu , Afriani Dwi Tika , Siswoyo Bambang Hendra
Published: February 2025

Penelitian ini bertujuan untuk mengetahui pengaruh perbedaan rasio jantan : betina terhadap natalitas larva ikan molly balon yang di hasilkan untuk memperoleh rasio yang terbaik bagi natalitas larva pasca pemijahan. Penelitian ini dilaksanakan pada 20 Maret 2024 di Laboratorium Fakultas Perikanan Universitas Dharnawangsa. Metode yang digunakan adalah metode eksperimen dengan menggunakan Rancangan Acak Lengkap yang terdiri dari 3 Perlakuan dan 3 Ulangan. Hasil analisis sidik ragam pengaruh rasio pemijahan terhadap natalitas larva ikan molly balon menunjukkan bahwa F Hitung > F Tabel yaitu 6,396 > 2,78% pada taraf uji 5% dan 6,396 > 4,22% pada taraf uji 1% yang menunjukkan bahwa perbedaan rasio pemijahan terhadap natalitas larva ikan molly balon berpengaruh nyata (significant). Berdasarkan hasil uji LSD terhadap natalitas larva bahwa perlakuan A dan perlakuan B berbeda nyata (significant), Perlakuan B dan Perlakuan C berbeda nyata (significant),dan perlakuan C dan Perlakuan A tidak ada perbedaan secara nyata (Non significant). Hasil penelitian menunjukkan Dari hasil perhitungan yang di lakukan selamaa penelitian di peroleh hasil sebagai berikut.Perlakuan B (1 : 2) menunjukkan hasil terbaik atau tertinggi dengan nilai rata – rata  94% diikuti dengan Perlakuan C (1 : 3) dengan nilai rata – rata 85,66% dan yang terendah ada pada Perlakuan A (1 : 1) dengan nilai rata – rata 83%.
Pengaruh Kosentrasi Ekstrak Daun Dan Biji Kecubung (Datura Matel L) Terhadap Proses Pembiusan Benih Ikan Nila (Oreochromis Niloticus) Selama Pengangkutan
Authors: Siregar Tommy Fernandes , Batubara Pebry Aisyah Putri , Siswoyo Bambang Hendra
Published: February 2025

Penelitian ini bertujuan Mengetahui pengaruh ekstrak daun dan biji kecubung (Datura matel, L) dalam pembiusan ikan nila (Oreochromis niloticus) selama proses pengangkutan dan mengetahui rata-rata perlakuan yang terbaik pemberian ekstrak daun dan biji kecubung (Datura matel, L) dalam pembiusan ikan nila (O niloticus) selama proses pengangkutan. Penelitian ini dilaksanakan pada tanggal 30 Januari sampai dengan 3 Februari 2018 bertempat di Belawan – Pematang Siantar. Metoda yang digunakan adalah metoda eksperimen dengan menggunakan Rancangan Acak Lengkap non faktorial yang terdiri dari 4 Perlakuan dan 3 ulangan. Kelulusan hidup tertinggi diperoleh pada perlakuan D sebesar 96,67 % sedangkan perlakuan yang terendah terdapat pada perlakuan A (kontrol) sebesar 50%. Berdasarkan analisis variansi menunjukkan pemberian ekstrak daun dan biji kecubung pengaruh nyata (highly significant) terhadap kelangsungan hidup ikan nila ( P> 0.01%). Hasil rata-rata kualitas air bak pembugaran pH 7,1- 8,3 dan DO 3,5- 4,4 m/l, dan Suhu 25- 280C.
الأساليب اللغوية الدخيلة في سلسلة العربية بين يديك
(المستوى الرابع أنموذجًا)
Authors: السلمي عطية الله جابر
Published: February 2025

الغاية من البحث دراسة الأساليب اللغوية الدخيلة في سلسلة العربية بين يديك (المستوى الرابع أنموذجًا)، تلك الأساليب المخالفة للفصاحة العربيّة التي أدخلت اللغة العربيّة بالترجمة الحرفيّة وتُسمّى (Calque)، تكمن المشكلة في محاولة التعرف على هذه الأساليب الدخيلة بالسلسلة، حيث لم تخضع هذه الأساليب للدراسة مع شيوعها في سلاسل تعليم العربية للناطقين بغيرها، طبّق الباحث هذه الدراسة في الفصل الدراسي الثاني من العام الدراسي ١٤٤٥هـ الموافق ٢٠٢٤م، معتمدًا المنهج التحليلي الوصفي، حيث صمّم أداة جمع فيها الأساليب اللغوية الدخيلة من مصادر شتّى حلّل بها كتاب العربية بين يديك المستوى الرابع (الجزء الأول)، وفي النتائج توصّل الباحث إلى نتائج أهمها، إحصاء وتصنيف الأساليب اللغوية الدخيلة بالسلسلة كمًّا وكيفًا، حيث صنّف الباحث الأساليب اللغويّة الدخيلة إلى أربعة أنواع، جاء منها في الكتاب الذي بين أيدينا ثلاثة أنواع: الكلميّ، والتركيبيّ، والقالبيّ، وسلم الكتاب عينة البحث من وقوع الأسلوب الحرفي بها، وبلغ عدد الأساليب الدخيلة للأنواع الثلاثة بالكتاب (٨١) أسلوبًا.
الكلمات المفتاحية: الترجمة الحرفيّة، تعريب الأساليب، الأساليب اللغوية الدخيلة، تعليم اللغة العربية للناطقين بغيرها، سلسلة العربية بين يديك المستوى الرابع.
purpose of the research is to study the alien linguistic styles in the Arabic in Your Hands series (the fourth level as an example), those styles that contradict Arabic eloquence that were introduced into the Arabic language through literal translation and are called (Calque). The problem lies in trying to identify these alien styles in the series, as these styles were not subject study, despite its popularity in Arabic teaching series for non-native speakers, The researcher applied this study in the second semester of the academic year 1445 AH corresponding to 2024 AD, adopting the descriptive analytical approach, where he designed a tool in which he collected foreign linguistic styles from various sources with which he analyzed the book Arabic in Your Hands, level four (Part One), In the results, the researcher reached the most important results, the most important of which is counting and classifying the linguistic styles that are foreign to the series quantitatively and qualitatively. The researcher classified the foreign linguistic styles into four types, of which three types appeared in the book in our hands: verbal, synthetic, and template, and the series was spared the occurrence of the literal style in them. The number of linguistic styles introduced into the series reached (81).
Keywords: literal translation, Arabization of styles, alien linguistic styles, teaching Arabic to non-native speakers, Arabic in Your Hands series, fourth level.
Evaluating Casat Falls in Bayombong, Nueva Vizcaya: A Local Tourism Gem
Authors: Tanguid Claudine P. , Balolong Rolie Mae B. , Cuesta Andrea Nicole Dela , Duran Erika Giselle N. , Layugan Kathrina Marie S. , Soriano Mr. Mark Ian J.
Published: February 2025

Casat Falls, located in Bayombong, Nueva Vizcaya, Philippines, is a natural attraction with significant potential for sustainable tourism development. This qualitative descriptive study assessed the site’s strengths, weaknesses, opportunities, and threats (SWOT) while identifying strategies to enhance its role as a tourist destination. Using interviews, ocular visits, observations, photo documentation and document scanning, the study focused on tourism aspects like accessibility, infrastructure, and management. The findings reveal that while Casat Falls boasts natural beauty and potential for ecotourism, it faces challenges such as inadequate facilities, rough access roads, and limited security measures. The SWOT analysis highlighted opportunities for local economic growth through increased promotion, particularly on social media, and collaboration with local authorities for future development projects. However, threats like rival attractions and property disputes pose risks to the site’s progress. Recommendations include improving amenities like restrooms and cottages, enhancing infrastructure, and promoting the falls through digital marketing. Training staff, improving security, and adding attractions like floral displays are also crucial for ensuring visitor satisfaction. Addressing these issues can transform Casat Falls into a sustainable and appealing destination, benefiting both the local economy and the community.
Intergenerational Transmission of Parenting Styles on Young Mothers in Kenya
Authors: Ayako Lornah Irene
Published: February 2025

This study examines the intergenerational transmission of parenting styles among young mothers in Kenya, investigating how the parenting practices of previous generations influence the current generation. The research uses a quantitative design, grounded in Vygotsky’s sociocultural theory, and focuses on young mothers aged 18-35 from both urban and rural areas of Kenya. A stratified random sampling technique was employed, with a sample size of 384 participants calculated using Cochran’s formula. Data were collected via structured questionnaires assessing authoritative, authoritarian, permissive, and neglectful parenting styles. Descriptive statistics, Pearson correlation, and multiple linear regression analyses were applied to explore the patterns and relationships between childhood and current parenting styles. Results revealed that authoritarian parenting was the most common style experienced by participants in childhood (M = 3.76, SD = 0.576), followed by permissive (M = 2.75, SD = 0.398) and authoritative (M = 2.44, SD = 0.461) styles. Neglectful parenting had the lowest mean (M = 1.96, SD = 0.351). In adulthood, the most prevalent style adopted by the young mothers was authoritative (M = 4.08, SD = 0.377), followed by permissive (M = 2.63, SD = 0.834), with authoritarian parenting being less commonly adopted (M = 2.49, SD = 0.852). The correlation analysis showed weak to moderate relationships between childhood and current parenting styles, with significant negative correlations between childhood authoritative parenting and current authoritarian (r = -0.109, p < 0.05) and permissive parenting (r = -0.236, p < 0.01). No significant correlation was found between childhood authoritarian or neglectful parenting and current parenting styles. The regression analysis indicated that demographic factors, particularly area of residence, were significant predictors of current authoritarian and permissive parenting styles. The study concludes that intergenerational transmission of parenting styles is present in Kenya, with cultural and socio-economic factors influencing parenting practices. These findings highlight the need for targeted interventions to address these influences and promote healthier parenting strategies.
Emotional Intelligence as a Mediator between Celebrity Endorsement and Gen-Z Consumer Behavior in Malaysia
Authors: Hudi Zainora Hayat , Ping Lee Hui , Munap Rudzi , Badrillah Muhammad Izwan Mohd , Arivanandan Yarshini
Published: February 2025

This study examines the mediating role of emotional intelligence in the relationship between celebrity influence and the purchasing behavior of Generation Z in Malaysia. In an era dominated by social media, celebrities have emerged as influential figures in shaping consumer preferences, particularly among younger generations. Despite the growing significance of celebrity endorsements, there remains limited research on the extent to which emotional intelligence influences or mediates this impact on consumer decision-making. This study seeks to address this gap by investigating how emotional intelligence affects the decision-making processes of Gen-Z consumers when exposed to celebrity endorsements. A quantitative research approach was employed, utilizing a survey to collect data from a representative sample of Gen-Z individuals in Malaysia. The survey assessed the levels of emotional intelligence, the impact of celebrity endorsements, and purchasing behavior. Statistical analyses were conducted to explore the relationships between these variables and to determine whether emotional intelligence acts as a mediator between celebrity influence and consumer purchasing decisions.

The results of the study reveal that emotional intelligence significantly mediates the relationship between celebrity influence and the purchasing behavior of Gen-Z consumers. Specifically, the study found that emotional intelligence enhances the perceived credibility and emotional appeal of celebrity endorsements, which, in turn, influences purchasing decisions. This suggests that the emotional connection fostered through celebrity endorsements is crucial for Gen-Z consumers, and that marketers should consider the role of emotional intelligence when crafting celebrity-based marketing campaigns. The findings of this study have practical implications for marketers and brands seeking to engage effectively with the Gen-Z demographic. By understanding the mediating role of emotional intelligence, brands can refine their marketing strategies to better resonate with this consumer group. This study contributes to the existing body of knowledge by highlighting the importance of emotional intelligence in the context of celebrity endorsements, offering valuable insights into the psychological mechanisms that drive purchasing behavior among Gen-Z consumers in Malaysia.
The Nexus between Biodiversity, Climate Change and Human Health in Kenya’s Drylands
Authors: Nunow Abdirizak Arale
Published: February 2025

Purpose: The study explores the intricate interplay between ecological diversity, climatic variability, and public health in one of Kenya's most vulnerable regions. The primary purpose of the research is to examine how biodiversity loss and climate change exacerbate health risks in Kenya's drylands, with a focus on identifying critical linkages and adaptive strategies for sustainable solutions.
Methodology: Using a mixed-methods approach, the study integrates quantitative climate and biodiversity data with qualitative insights gathered from community interviews, health records, and participatory observation.
Findings: Findings reveal a strong correlation between declining biodiversity and increased susceptibility to climate-induced health risks such as vector-borne diseases, malnutrition, and water scarcity. Communities relying heavily on natural ecosystems for sustenance and traditional medicine are disproportionately affected, highlighting the critical role of biodiversity in climate resilience and public health.
Unique Contribution to Theory Policy and Practice: The study concludes that the degradation of ecosystems amplifies vulnerabilities, while sustainable management of biodiversity offers a viable path to mitigating health risks. Recommendations emphasize the need for integrated policy frameworks that align biodiversity conservation with climate adaptation and public health strategies. The study advocates for community-driven initiatives, enhanced resource management, and targeted education programs to build resilience in Kenya's drylands. These findings underscore the urgency of addressing interconnected challenges to safeguard ecological and human well-being in the face of climate change.
Carbon Trading in Kenya: Challenges and Opportunities
Authors: Nunow Abdirizak Arale
Published: February 2025

Purpose: The purpose of the study is to assess the current status of carbon trading in Kenya, identify the challenges inhibiting its growth, and evaluate the opportunities it presents for economic and environmental progress.
Methodology: A mixed-methods approach was adopted, combining qualitative interviews with key stakeholders, such as policymakers, carbon project developers, and local community representatives, along with a quantitative analysis of carbon market trends and project performance data.
Findings: The findings reveal significant barriers to the effective implementation of carbon trading, including weak regulatory frameworks, limited awareness among local communities, inadequate technical expertise, and challenges related to accessing international carbon markets. Despite these obstacles, the study highlights substantial opportunities, such as leveraging Kenya's abundant renewable energy resources, enhancing community participation in carbon offset projects, and tapping into global demand for certified emissions reductions.
Unique Contribution to Theory, Policy and Practice: The study concludes that while carbon trading in Kenya remains underdeveloped, it holds considerable potential to contribute to climate resilience and economic growth if systemic barriers are addressed. Key recommendations include strengthening policy and institutional frameworks, enhancing capacity-building initiatives, improving access to financing for carbon projects, and fostering public-private partnerships to scale up investments in carbon trading. By addressing these challenges, Kenya can position itself as a leader in sustainable carbon market practices in Africa.
Development of Learning Devices Using the Scientific Inquiry Learning Model Based on Malay Culture to Increase Student Self Efficacy
Authors: Putrini R Harahap Saima , Kurnila Nely
Published: February 2025

The goal to be achieved is the increase in student self-efficacy through the development of learning tools using a scientific inquiry learning model based on Malay culture. This research is categorized into types of development research. The developed device uses a 4-D model. This research was conducted in the Mining Technology Study Program at the Ketapang State Polytechnic, class 1-B, with 28 students. According to the results of expert validation, the learning tools that have been developed in this research are of good quality and meet valid criteria by the validator, so they are suitable for use as learning tools. Implementation of learning tools in the practical category (very good). More than 80% of student responses were positive towards learning. The average student self-efficacy questionnaire results showed an increase from pretest to posttest in Trial II, with the pretest score being 83.43 and the posttest score reaching 119.32, out of a maximum score of 140. Based on these results, it can be concluded that student self-efficacy improved after implementing the learning devices using the scientific inquiry model based on Malay culture, as evidenced by the increase in scores from the pre-test to the post-test in Trial II.
Sınıf Öğretmenlerinin Kapsayıcı Eğitime Yönelik Tutumları ve Özyeterlikleri
Authors: Kuşça Nesih , Demirkol Mehmet
Published: February 2025

Bu araştırmanın amacı, sınıf öğretmenlerinin kapsayıcı eğitime yönelik tutum ve özyeterliklerini belirlemek ve bu iki değişken arasındaki ilişkiyi incelemektir. Araştırmanın evrenini, 2022-2023 eğitim öğretim yılı Diyarbakır il merkezinde görev yapan sınıf öğretmenleri oluşturmaktadır. Bu evrenden, oranlı ve tesadüfi örnekleme yöntemiyle seçilen 648 öğretmen örneklem olarak belirlenmiştir.
Araştırmanın veri toplama sürecinde, Kieblock (2018) tarafından geliştirilen ve Demirkol ve Kuşça (2023) tarafından Türkçeye uyarlanan Kapsayıcı Eğitime Yönelik Öğretmen Tutum Ölçeği ve Kapsayıcı Eğitime Yönelik Öğretmen Özyeterlik Ölçeği kullanılmıştır. Verilerin analizinde betimsel istatistikler ile parametrik testler olan 'Bağımsız Gruplar T Testi' ve 'Tek Yönlü Varyans Analizi (ANOVA)' kullanılmıştır. İstihdam durumu değişkeni için ise non-parametrik testlerden 'Mann-Whitney U Testi' uygulanmıştır. Ayrıca, kapsayıcı eğitime yönelik tutum ve özyeterlikler arasındaki ilişki Pearson Momentler Çarpımı Korelasyon Katsayısı ile analiz edilmiştir.
Araştırma sonuçlarına göre, yaş, cinsiyet ve öğrenim durumu değişkenlerinin kapsayıcı eğitime yönelik tutum ve özyeterlik algılarında anlamlı bir fark yaratmadığı belirlenmiştir. Ancak, kapsayıcı eğitime yönelik deneyim sahibi olma ve hizmet içi eğitim-seminer alma değişkenlerinde anlamlı farklılıklar gözlemlenmiştir. Kapsayıcı eğitime yönelik tutum boyutları ile özyeterlik arasındaki ilişkiler incelendiğinde, vizyon boyutunun özyeterlik ile güçlü bir pozitif ilişkiye, farklılaştırma boyutunun orta düzeyde pozitif ilişkiye ve destekleme boyutunun zayıf bir pozitif ilişkiye sahip olduğu bulunmuştur. Genel uygulama boyutu ile özyeterlik arasında ise zayıf bir negatif ilişki tespit edilmiştir.
Eğitim Örgütlerinde Makyavelist Liderlik: Değerlendirme ve İncelenmesi
Authors: Demir Arıcı İrem , Kocabaş Prof. Dr. İbrahim
Published: February 2025

Bu çalışma, eğitim örgütlerinde makyavelist liderlik yaklaşımının kullanımını analiz ederek değerlendirmeyi amaçlamaktadır. Makyavelist liderlik, İtalyan düşünür Niccolò Machiavelli'nin eserlerinden ilham alan ve liderlikte güç, manipülasyon ve stratejik düşünmeyi ön plana çıkaran bir yaklaşım olarak tanımlanabilir. Bu tür liderler, genellikle amaçlarına ulaşmak için her türlü yöntemi benimsemeye eğilimlidirler ve etik normlara esnek bir tutum sergileyebilirler. Makyavelist liderliğin avantajları arasında hızlı karar verme, etkili kriz yönetimi ve hedeflere odaklanma yeteneği bulunurken, aşırı kullanımı güven kaybına, işbirliğinin azalmasına ve uzun vadede olumsuz etkilere yol açabilir (Shultz & Shriver, 2014). Bu liderlik anlayışı, belirli durumlarda etkili olabilse de, dengeli ve dikkatli bir şekilde uygulanması gereklidir. Eğitim örgütlerinde bu yaklaşım, hızlı karar almayı, hedef odaklı çalışmayı ve yönetimde etkinliği teşvik edebilir. Ancak, ölçüsüz bir şekilde kullanıldığında, güvensizlik, işbirliği eksikliği ve öğrenci odaklılıktan uzaklaşma gibi olumsuz sonuçlar ortaya çıkabilir (Kessler et al, 2010; Park & Keil, 2009). Araştırmalar, makyavelist liderliğin örgüt içindeki performansı ve üretkenliği hem olumsuz hem de olumlu yönde etkileyebileceğini göstermektedir. Bu bağlamda, bu çalışma makyavelist liderliğin eğitim örgütleri üzerindeki etkilerini değerlendirirken, bu yaklaşımın dengeli bir şekilde uygulanmasının önemini vurgulamaktadır (O’Boyle et al., 2012). Liderlerin, güçlü karar alma ve hedefe yönelik çalışma gibi olumlu özellikleri benimserken, işbirliği, güven ve öğrenci odaklılık gibi temel değerlere de öncelik vermesi gerektiği belirtilmektedir. Özellikle, kendilerini geliştirmek veya çevrelerine olumlu bir izlenim bırakmak istediklerinde, makyavelist liderlerin prososyal kişilerarası stratejilere başvurarak, yıkıcı ve aldatıcı davranışlardan kaçınmaları gerektiği vurgulanmaktadır. Sonuç olarak, makyavelist liderlik yaklaşımının eğitim örgütlerinde bilinçli ve dengeli bir şekilde uygulanması, okul kültürünün iyileştirilmesine ve öğrenci başarısının artırılmasına katkı sağlayabilir.
Cumhuriyetin İlk Sabahı Kitabının Sosyal Bilgiler Dersi Öğretim Programında Yer Alan Değerler Açısından Değerlendirilmesi
Authors: Utkugün Ceren , Erdoğan Yapici Kevser , Ortak Şaban
Published: February 2025

Cumhuriyetin İlk Sabahı adlı kitap, Millî Mücadele yılları ve Cumhuriyetin kuruluş hikayesini bir şerbetçi çocuğun gözünden etkileyici bir şekilde ele almaktadır. Kitap, tarihsel derinlik sunmasının yanı sıra, öğrencilerin yaşlarına uygun bir bakış açısı barındırmasıyla değerler eğitimi açısından da önemli bir kaynak olarak öne çıkmaktadır. Bu araştırmanın amacı, Cumhuriyetin İlk Sabahı kitabını Sosyal Bilgiler Dersi Öğretim Programı’nda (2024) yer alan değerler çerçevesinde incelemektir. Araştırmada nitel araştırma yöntemlerinden doküman analizi kullanılmıştır. Şermin Yaşar ve İlber Ortaylı tarafından yazılan, 120 sayfa ve 6 bölümden oluşan, 2023 yılında Kronik Kitap tarafından yayınlanan Cumhuriyetin İlk Sabahı isimli kitap araştırmanın veri kaynağını oluşturmuştur. Araştırma verilerinin analizinde içerik analizi kullanılmış, elde edilen veriler kitap içeriğinden yapılan doğrudan alıntılarla desteklenerek sunulmuştur. Araştırma sonucunda; Cumhuriyet’in İlk Sabahı kitabında en çok vatanseverlik, çalışkanlık ve sorumluluk değerlerine yer verildiği, sevgi, yardımseverlik ve duyarlılık gibi değerlerin de ön plana çıktığı belirlenmiştir. Kitabın, Milli Mücadele dönemi ve Cumhuriyetin kuruluş sürecine uygun bir içerik sunarak çocuklara hem milli hem de evrensel değerler kazandırma açısından önemli bir katkı sağladığı tespit edilmiştir. Araştırmada elde edilen sonuçlara göre, sosyal bilgiler derslerinde değerler eğitimi kapsamında Cumhuriyet’in İlk Sabahı gibi edebi eserlerin kullanımının teşvik edilmesi, öğrencilerin değerleri özümseyebilmeleri için yaratıcı etkinliklerin planlanması ve öğretmenlere bu eserlerin etkili kullanımına yönelik atölye çalışmalarının düzenlenmesi önerilmiştir.
KAHRAMANMARAŞ DEPREMİNDE UYANAN BİR AĞIT: “MARAŞ MARAŞ DA BU NASIL MARAŞ” VE SÖZLÜ TARİH
Authors: Fidan Süleyman , Güven Mahmut
Published: February 2025

ÖZ
Geleneksel müzik temsilcileri geçmişten günümüze eserleri aracılığıyla halkın sözcülüğünü yapmış, toplumsal konulara değinmişlerdir. Halkın sözcülüğünü yapan sözlü kültür temsilcilerinin bazı eserleri sözlü gelenekte kuşaklararası aktarımla yaşamaya devam etmiştir. Özellikle ağıt tarzında ürünler dinamik yapılarıyla bellekte güncellenerek varlıklarını sürdürmüşlerdir. Kahramanmaraş tarihi boyunca sosyal ve siyasî olayların neticesinde acı sahnelere şahit olmuş, salgın hastalıklarla kitlesel ölümler görmüş, aynı zamanda birçok deprem felaketi yaşamıştır. Yaşanılan olaylar binlerce insanın yaralanmasına ve ölmesine sebep olmuştur. Yöredeki farklı türküler zamanla toplumun duygularına tercüman olmuş, çeşitli değişim-dönüşüm geçirmiştir. Bunun sonucunda söz konusu olan türküler dinamik yapısını koruyarak yeni anlamlar kazanmış, yaşanılan duyguları dile getirmede vasıta olmaya devam etmiştir.
Makale kapsamında Kahramanmaraş’ta yaşanan trajik olayları anlatan, Maraş’ın geçmişini anlamak ve yorumlamak adına sözlü kültür belleğinde hâlâ yaşayan “Maraş Maraş da Bu Nasıl Maraş” adlı bir ağıt ele alınmıştır. Bu çalışmada söz konusu ağıdın yakılmasına neden olan olaylar ve bu olaylar sonucunda halkın hissettiği duygular incelenmektedir. “Maraş Maraş da Bu Nasıl Maraş”; Maraş’ta yaşayan halkın Kurtuluş Savaşı Dönemi’nde verdikleri mücadele, 1978 yılında bölgede çıkan olaylarda yaşanılanlar ve 6 Şubat 2023 tarihinde merkez üssü Kahramanmaraş olan 7.7 ve 7.6 büyüklüğündeki iki depremden sonra yörede yaşayan halkın yaşadığı çeşitli acılar sözlü kültür geleneğinde kendini yenileyen bir ağıt olarak yeni anlamlar kazandığı düşünülmektedir. Bu çalışmanın konusunu teşkil eden “Maraş Maraş da Bu Nasıl Maraş” türküsünün tespit edilen varyantları mukayese edilerek metnin anlamsal çözümlemesi yapılmıştır. Ayrıca yaratılışı, oluşum şartları, Kahramanmaraş’ın tarihine tanıklık eden yönleri; sözlü tarih bağlamında, sözlü kültürün dinamizmi, sözel bellekte yaşayan ürünlerin farklı olaylar karşısındaki uyanışı incelenmiştir.
Aporte a la conservación de las fuentes hídricas para la enseñanza de la ciencia desde las comunidades indígenas de Pastos y Tukano
Authors: Revelo Pascumal Vivian , Cuellar Natalia , Grajales Fonseca Alexandra
Published: February 2025

The importance of rescuing ancestral knowledge lies in remembering the way of life, the customs, customs and traditions that the ancestors have transmitted over time. In order to determine the contribution of the indigenous communities of Pastos and Tukano in the Males and La Asunción Reservations to water sources, and to promote their rescue and revaluation for science teaching, a qualitative study is presented. Using instruments for the collection of knowledge and with the help of the captains, leaders and elders of each reservation - who have the innate knowledge and the appropriate technique that has given results throughout different generations - the information was collected through interviews, surveys and a field diary in each reservation. In this way, it was possible to reflect and rescue the knowledge of communities located geographically on opposite sides of Colombia, both in the southwest and southeast of the country.
Cadenas Globales de Valor: modelo para la aplicaciónde una cadena de valor regional centroamericana
Authors: Rojas Rojas Johan , Campos María de los Ángeles , Carranza Cambronero Karen
Published: February 2025

The paper discusses regional value chains in the development of international trade relations to promote the competitiveness of a specific business sector, in the field of the market of interest. The importance of understanding a country's participation in international trade flows is raised and establishing a Central American model of regional value chains is proposed. In which, public policies stand out to reduce inequality and generate employment through global value chains is Highlighted. The benefits and challenges of global value chains are mentioned for strategies of transnational corporations’ context. At the end, a model is proposed for applying a regional value chain in Central America, highlighting the relevance of integration at the regional level for strengthening public policies. At the same time, motivating questions are asked for future researchers of the regional value chains for medical devices in the Central American region.
El impacto de las variables seleccionadas en la tasa de desempleo de una región determinada
Authors: Kwasniewski Jacek Piotr
Published: February 2025

Unemployment is a permanent element of the market economy that negatively affects the entire society. This research aims to analyze the impact of selected variables on the unemployment rate. The scope of the research covered the years 2009 to 2023, and their analysis was carried out using an econometric model, which allowed for the estimation of the impact of selected variables on the unemployment rate. The analysis showed that increasing the demographic burden and the number of people has a significant impact on reducing the unemployment rate. The values of the determination coefficient suggest that the model describes the unemployment phenomenon well. Although the time series showed a downward trend for the unemployment rate, the possible forecasting was burdened with too much error. The research results can contribute to a better understanding of the factors influencing the unemployment rate. Appropriate adjustment of educational programs related to the obtained results can contribute to reducing the unemployment rate and improving the situation in the local labour market.
Inteligencia Artificial General, Desarrollo Humano y Sostenibilidad
Authors: Aparicio-Gómez Oscar-Yecid , Aparicio-Gómez William-Oswaldo
Published: February 2025

General artificial intelligence (AGI) represents an unprecedented technological advancement with the potential to transform multiple dimensions of human development and sustainability. This article explores the implications of AGI in areas such as green economy, social justice, public health, inclusive education, and responsible business practices. Through an interdisciplinary analysis, the challenges and opportunities posed by AGI to achieve the United Nations Sustainable Development Goals (SDGs) are examined. It is concluded that, although AGI offers powerful tools to address complex global problems, its implementation must be guided by ethical principles and a human-centered approach to ensure that its benefits are equitable and sustainable.
The reproductive health education to adolescents with intellectual disabilities: Perspectives of parents, teachers, and caregivers
Authors: Pandia Weny Savitry S. , Widyawati Yapina , Handayani Penny , Sutamto Edwin
Published: February 2025

Teaching reproductive health knowledge from an early age to children and adolescents with intellectual disabilities is essential. They are more susceptible to sexual abuse and to developing inappropriate sexual behaviour than typical children. This research aims to explore the understanding of parents, teachers and caregivers regarding the reproductive health of children and adolescents with intellectual disabilities and the challenges parents face in providing reproductive health and sexuality education. The research methods are a literature review of 27 articles and group interviews attended by 13 participants consisting of parents, teachers and caregivers of children with intellectual disabilities. Results show that reproductive health issues faced by children with intellectual disabilities are not fully understood by parents, teachers, and caregivers, which contributes to challenges in providing reproductive health and sexuality education to children. Existing intervention programs need to be equipped with tools, while the program’s content and method of information delivery need to be improved.