bluuebunny/crossref_metadata_2025 huggingface dataset:
Plasma Metabolomics and Lipidomics Differentiate Obese Individuals by Peripheral Neuropathy Status
Authors: Guo Kai , Savelieff Masha G , Rumora Amy E , Alakwaa Fadhl M , Callaghan Brian C , Hur Junguk , Feldman Eva L
Published: December 2021

Context

Peripheral neuropathy (PN) is a frequent prediabetes and type 2 diabetes (T2D) complication. Multiple clinical studies reveal that obesity and dyslipidemia can also drive PN progression, independent of glycemia, suggesting a complex interplay of specific metabolite and/or lipid species may underlie PN.

Objective

This work aimed to identify the plasma metabolomics and lipidomics signature that underlies PN in an observational study of a sample of individuals with average class 3 obesity.

Methods

We performed plasma global metabolomics and targeted lipidomics on obese participants with (n = 44) and without PN (n = 44), matched for glycemic status, vs lean nonneuropathic controls (n = 43). We analyzed data by Wilcoxon, logistic regression, partial least squares–discriminant analysis, and group-lasso to identify differential metabolites and lipids by obesity and PN status. We also conducted subanalysis by prediabetes and T2D status.

Results

Lean vs obese comparisons, regardless of PN status, identified the most significant differences in gamma-glutamyl and branched-chain amino acid metabolism from metabolomics analysis and triacylglycerols from lipidomics. Stratification by PN status within obese individuals identified differences in polyamine, purine biosynthesis, and benzoate metabolism. Lipidomics found diacylglycerols as the most significant subpathway distinguishing obese individuals by PN status, with additional contributions from phosphatidylcholines, sphingomyelins, ceramides, and dihydroceramides. Stratifying the obese group by glycemic status did not affect discrimination by PN status.

Conclusion

Obesity may be as strong a PN driver as prediabetes or T2D in a sample of individuals with average class 3 obesity, at least by plasma metabolomics and lipidomics profile. Metabolic and complex lipid pathways can differentiate obese individuals with and without PN, independent of glycemic status.
Adipose-specific VDR Deletion Leads to Hepatic Steatosis in Female Mice Fed a Low-Fat Diet
Authors: Tao Tao , Kobelski Margaret M , Saini Vaibhav , Demay Marie B
Published: December 2021

Risk factors for nonalcoholic hepatic steatosis include obesity and vitamin D deficiency which commonly coexist. Thus, the role of vitamin D signaling in the prevention of hepatic steatosis in the absence of obesity or a “Western” high-fat diet is unclear. These studies were performed to address the role of the adipocyte vitamin D receptor (VDR) in the prevention of hepatic steatosis in mice fed a chow diet containing 5% fat by weight.

Female mice with adipocyte VDR ablation (Adipoq-Cre; VDRflox/flox) exhibited a mild increase in weight gain at age 70 days, accompanied by an increase in visceral white adipose tissue (VAT) weight. While they did not exhibit evidence of hepatic inflammation or fibrosis, an increase in hepatic lipid content was observed. This was accompanied by an increase in the hepatic expression of genes involved in fatty acid transport and synthesis, as well as fatty acid oxidation. Markers of hepatic inflammation and fibrosis were unaffected by adipocyte VDR ablation. Consistent with the increase in VAT weight in the Adipoq-Cre; VDRflox/flox mice, higher levels of transcripts encoding adipogenesis-related genes were observed in VAT.

In contrast to other models of impaired vitamin D signaling studied in the setting of a high-fat or “Western” diet, the Adipoq-Cre; VDRflox/flox mice do not exhibit hepatic inflammation or fibrosis. These findings suggest that the adipocyte VDR regulates hepatic lipid accumulation, but in the absence of obesity or a high-fat diet, is not required to prevent hepatic inflammation or fibrosis.
Stabilization of β-catenin promotes melanocyte specification at the expense of the Schwann cell lineage
Authors: Colombo Sophie , Petit Valérie , Wagner Roselyne Y. , Champeval Delphine , Yajima Ichiro , Gesbert Franck , Aktary Zackie , Davidson Irwin , Delmas Véronique , Larue Lionel
Published: December 2021

The canonical Wnt/β-catenin pathway governs a multitude of developmental processes in various cell lineages, including the melanocyte lineage. Indeed, β-catenin regulates transcription of Mitf-M, the master regulator of this lineage. The first wave of melanocytes to colonize the skin is directly derived from neural crest cells, whereas the second wave of melanocytes is derived from Schwann cell precursors (SCPs). We investigated the influence of β-catenin in the development of melanocytes of the first and second waves by generating mice expressing a constitutively active form of β-catenin in cells expressing tyrosinase. Constitutive activation of β-catenin did not affect the development of truncal melanoblasts but led to marked hyperpigmentation of the paws. By activating β-catenin at various stages of development (E8.5-E11.5), we showed that the activation of β-catenin in bipotent SCPs favored melanoblast specification at the expense of Schwann cells in the limbs within a specific temporal window. Furthermore, in vitro hyperactivation of the Wnt/β-catenin pathway, which is required for melanocyte development, induces activation of Mitf-M, in turn repressing FoxD3 expression. In conclusion, β-catenin overexpression promotes SCP cell fate decisions towards the melanocyte lineage.
Msl3 promotes germline stem cell differentiation in female Drosophila
Authors: McCarthy Alicia , Sarkar Kahini , Martin Elliot T. , Upadhyay Maitreyi , Jang Seoyeon , Williams Nathan D. , Forni Paolo E. , Buszczak Michael , Rangan Prashanth
Published: December 2021

Gamete formation from germline stem cells (GSCs) is essential for sexual reproduction. However, the regulation of GSC differentiation is incompletely understood. Set2, which deposits H3K36me3 modifications, is required for GSC differentiation during Drosophila oogenesis. We discovered that the H3K36me3 reader Male-specific lethal 3 (Msl3) and histone acetyltransferase complex Ada2a-containing (ATAC) cooperate with Set2 to regulate GSC differentiation in female Drosophila. Msl3, acting independently of the rest of the male-specific lethal complex, promotes transcription of genes, including a germline-enriched ribosomal protein S19 paralog RpS19b. RpS19b upregulation is required for translation of RNA-binding Fox protein 1 (Rbfox1), a known meiotic cell cycle entry factor. Thus, Msl3 regulates GSC differentiation by modulating translation of a key factor that promotes transition to an oocyte fate.
Visualizing polymeric components that define distinct root barriers across plant lineages
Authors: Sexauer Moritz , Shen Defeng , Schön Maria , Andersen Tonni Grube , Markmann Katharina
Published: December 2021

Hydrophobic cell wall depositions in roots play a key role in plant development and interaction with the soil environment, as they generate barriers that regulate bidirectional nutrient flux. Techniques to label the respective polymers are emerging, but are efficient only in thin roots or sections. Moreover, simultaneous imaging of the barrier constituents lignin and suberin remains problematic owing to their similar chemical compositions. Here, we describe a staining method compatible with single- and multiphoton confocal microscopy that allows for concurrent visualization of primary cell walls and distinct secondary depositions in one workflow. This protocol permits efficient separation of suberin- and lignin-specific signals with high resolution, enabling precise dissection of barrier constituents. Our approach is compatible with imaging of fluorescent proteins, and can thus complement genetic markers or aid the dissection of barriers in biotic root interactions. We further demonstrate applicability in deep root tissues of plant models and crops across phylogenetic lineages. Our optimized toolset will significantly advance our understanding of root barrier dynamics and function, and of their role in plant interactions with the rhizospheric environment.
Methods based on a semi-empirical model for simulating scroll compressors with HFC and HFO refrigerants
Authors: Meramveliotakis George , Kosmadakis George , Karellas Sotirios
Published: December 2021

The aim of this work is to evaluate three methodologies regarding semi-empirical scroll compressor modeling for different refrigerants and conduct a comparative analysis of their results and accuracy. The first step is to improve a semi-empirical model for scroll compressors based on established techniques, and further enhance the physical background of some of its sub-processes leading to more accurate predictions. Focus is then given on the compressor operation when changing the refrigerant, proposing three methods in total. The first method refers to the standard model, requiring an optimization process for the calibration of all the model parameters. The second method relies on a reference refrigerant, and also uses optimization procedures, but for the fine-tuning of a small subset of the parameters. The third method is more generalized, without the need of any optimization process for the parameters identification, when fluid change occurs, leading to a very fast approach. Το evaluate the accuracy and verify the applicability of each method also related to the necessary computational time, two scroll compressors each with three different refrigerants are considered (HFCs and HFOs and their blends). The model is evaluated with the available manufacturer data, using R134a as reference refrigerant. The results show that the first method predicts the key indicators with a very high accuracy, with the maximum discrepancy of 2.06%, 4.17% and 3.18 K for the mass flow rate, electric power and discharge temperature respectively. The accuracy of the other two methods is dropping, but within acceptable levels in most of the cases. Therefore, in cases that reduced accuracy can be accepted, the third method is preferred for compressor performance prediction when changing the refrigerant, which provides results at a small fraction of time compared with the other two methods, once the parameters are calibrated for a reference case.
Wpływy polityczne w samorządzie gmin wiejskich województwa kieleckiego w latach 1918–1939
Authors: Ciosek Ireneusz
Published: December 2021

Po 1918 r. mieszkańcy wsi stanowili większość obywateli odrodzonego państwa i od ich postawy politycznej zależało powodzenie budowy skonsolidowanego społeczeństwa obywatelskiego. Występujące wówczas w środowisku wiejskim antagonizmy społeczne, ekonomiczne i narodowościowe, jak również słaby stopień identyfikacji chłopów z odrodzonym państwem polskim nie ułatwiały tego zadania. Przyjęte rozwiązania ustrojowo-prawne, w tym powołanie samorządu gminnego, jak i zapowiedź reformy rolnej, miały politycznie i materialnie związać mieszkańców wsi z państwem polskim. Środowisko wiejskie na ogół pozytywnie odniosło się do kształtu powołanego samorządu gminnego, tym bardziej że w województwie kieleckim istniała już tradycja gminy zbiorowej.
Walka o prymat w stanowieniu prawa między Izbą Lordów a Izbą Gmin na początku XX wieku
Authors: Jaeschke Andrzej
Published: December 2021

Na przełomie XIX i XX wieku w parlamencie westminsterskim rozegrał się jeden z najważniejszych, trwający wiele lat akt konkurencji między obydwoma izbami parlamentu o wpływ na realizację funkcji ustawodawczej w procedurze parlamentarnej. W niniejszym artykule, będącym wynikiem znacznie szerszych studiów nad przekształceniami wewnętrznymi parlamentaryzmu brytyjskiego, przedstawiono społeczne i polityczne tło tej walki toczącej się na forum obydwu izb między dwiema siłami politycznymi: Partią Konserwatywną i Partią Liberalną, wzmocnioną przez taktycznych sojuszników. W tekście starano się przedstawić prawny wynik tego sporu w postaci słynnego Parliament Act 1911, ale także – na podstawie dzisiejszego stanu wiedzy opartego również na zachowanych stenogramach wystąpień parlamentarnych – klimat tego sporu oraz jego społeczne i polityczne tło.
Mein Kampf. Moja walka. Edycja krytyczna, z języka niemieckiego przełożył, wstępem, przypisami i bibliografią selektywną opatrzył Eugeniusz Cezary Król, Bellona, Warszawa 2020, ss. 1000
Authors: Grochowina Sylwia
Published: December 2021

recenzja
Validação do questionário de saúde e performance para policiais e bombeiros militares (QSPM)
Authors: Paulo Anderson Caetano , Rodacki Cintia  de Lourdes Nahhas , Caetano Hallyne Bergamini Silva , Cabral Alexandre dos Santos , Hoinatski Rodrigo , Caetano Cristiano Israel , Rodriguez-Añez Ciro Romelio , Fermino Rogério César
Published: December 2021

O objetivo deste estudo foi desenvolver e analisar a validade de conteúdo, constructo e a fidedignidade de um questionário para avaliar a demanda física e operacional, saúde e condições de trabalho em policiais e bombeiros militares. O Questionário de Saúde e Performance para Militares (QSPM) foi desenvolvido por pesquisadores militares e não militares, a validade foi analisada com o índice de validade de conteúdo (IVC), análise fatorial exploratória e a fidedignidade com o percentual de concordância (%C), coeficiente Kappa e alfa de Cronbach. Nove juízes participaram da validação de conteúdo, 732 militares (15% mulheres) participaram da etapa de validação de constructo e 262 militares (18% mulheres) responderam duas vezes ao QSPM para a verificação da fidedignidade. As análises foram realizadas no software SPSS 26 e o nível de significância mantido em 5%. O QSPM apresentou o IVC de 0,98 e variância total explicada em 54,7%. A reprodutibilidade apresentou valores de %C entre 97,2 - 100,0%, Kappa entre 0,94 - 1,00 (p < 0,05) e alpha de Cronbach entre 0,80 - 1,00 (p < 0,05). Conclui-se que o QSPM apresentou validade de conteúdo, constructo e fidedignidade para avaliar a frequência da demanda física e operacional, as condições de saúde e de trabalho de policiais e bombeiros militares.
Organizing Form, Experimentation, and Performance: Innovation in the Nascent Civilian Drone Industry
Authors: Bremner Robert P. , Eisenhardt Kathleen M.
Published: December 2021

Our aim is to explore whether the benefits to firms of using community-based innovation extend to nascent markets: uncertain, high-velocity settings with novel, often complex products. Grounded in a rare empirical comparison, we closely track the two ventures (one using community-based innovation and the other firm-based) that pioneered the nascent civilian drone market. We unpack how each addressed the three major innovations that shaped this setting. Our primary insight is that the firm organizing form for innovation performs best relative to communities in nascent markets. Firms have a coordination advantage that enables quickly and accurately targeting experimentation and problem-solving processes to reduce the many specific uncertainties that characterize these markets. Although communities can help, their task self-selection advantage works best in stable settings such as established markets with simple products (e.g., modular software) and in ambiguous settings in which low-cost randomness pays off. Broadly, we contribute a theoretical framework that identifies how organizing form and problem type jointly shape innovation performance. Most important, uncertainty forms a boundary condition for when firms should rely on firm-based (versus community-based) organizing for innovation.
Representation of violence value in Joker Film
Authors: Rosita Eva , Prathisara Gibbran
Published: December 2021

The Joker film aired in Indonesia on October 2, 2019. This film was widely discussed by the audience and succeeded in bringing the audience into the atmosphere of the film. This is because the problems that are taken often occur in the life of the general public. This film tells the story of Arthur aka Joker, whose life is filled with sadness, cheating, injustice as a lower middle-class citizen so that he is treated inappropriately by society and his family. Everything that happened to him resulted in the victim becoming the perpetrator of violence. Researchers are interested in analyzing the Joker film more deeply, and this is because the shows in the film contain violence that can trigger various physical and mental conditions such as aggressive behaviour, violent behaviour, bullying, fear, depression and nightmares for those who watch it. The purpose of this research is to find out how the representation of violence in the Joker film viewed from the Semiotics of Roland Barths to determine a meaning using the concepts of denotation, connotation, and myths taken from several scenes that represent the value of violence in the Joker film. The findings from the results of this study indicate that there are 16 scenes that present violence. The violence is in the form of physical violence, psychological violence, financial violence, functional violence, and rational violence. The Joker film shows that perpetrators of violence still often occur in life, even victims can become perpetrators of what happened to them. Often times people think this is normal because not everyone understands the importance of humanity and justice for others.
Using virtual reality to enhances efforts for introduce cultural heritage
Authors: Arfin Sadiq Zeinel
Published: December 2021

At present, cultural heritage is in a dangerous condition and it is all influenced by several factors such as natural disasters and man-made disasters. For example, in Indonesia in March 2018 there was a destruction of the Dayak Indigenous Sites whose cases were damaged due to human factors, not to mention talking about the destruction of damaged cultural sites such as in several countries such as Iraq, Syria, Afghanistan & Indonesia. The use of technology-based Virtual Reality (VR) in maintaining cultural heritage is very important because the identity that is in cultural heritage is the foundation of evidence of human life in the past. Threats in the form of human behavior and natural disasters have an impact of erasing historical and cultural traces which could threaten a nation in relation to the main national interests of a country. Maximizing the benefits of technological advancements by using Virtual Reality as an alternative to preserve cultural heritage & cultural exploration, this utilization can lower the cost of study of cultural exploration such as exploration of cultural heritage locations that are far especially in transport costs.
Urinoir Analyzer Pintar Pendeteksi Kelainan Pada Fungsi Ginjal Dengan Analisis Kadar Ph Dan Warna Pada Urin
Authors: Febryansah M. Iqbal , Yudhana Anton , Ma'arif Alfian
Published: December 2021

Perkembangan pemeriksaan penyakit kelainan ginjal melalui analisa urin saat ini dilakukan dalam dua proses pemeriksaan secara makroskopis dan mikroskopis. Pada dasarnya dibutuhkan sebuah alat yang mampu memproses dan menganalisis sebuah sampel urin secara otomatis agar tidak terjadinya kesalahan dalam melakukan pemeriksaan penyakit melalui sampel urin. Awalan perkembangan ini menggunakan sebuah Kontroler Arduino UNO dan dua buah variabel masukan yaitu sensor warna TCS3200 dan sensor PH meter SKU SEN0161. Dua buah variabel masukan sensor bekerja secara berdampingan dengan sensor TCS3200 memiliki hasil keluaran berupa nilai frekuensi RGB dan diproses kembali menjadi frekuensi keabuan. Lalu, sensor PH meter SKU SEN0161 menghasilkan sebuah nilai PH pada sampel urin. Hasil dari pemeriksaan tersebut ditampilkan pada sebuah penampil berupa LCD berukuran 16x2. Hasil pemeriksaan dari alat ini dibandingkan dengan hasil analisa pakar dari Balai Laboratorium Kesehatan Yogyakarta bagian Urology. dan mendapatkan tingkatan nilai akurasi 93% dengan keberhasilan data sebanyak 28 dari 30 data yang diambil.Â The development of examining kidney disorders through urine analysis is currently carried out in two processes of examination, macroscopic and microscopic. Basically, we need a tool that is able to process and analyze a urine sample automatically so that there are no errors in carrying out disease checks through the urine sample. The beginning of this development used an Arduino UNO controller and two input variables, namely the TCS3200 color sensor and the SKU SEN0161 PH meter sensor. Two sensor input variables working side by side with the TCS3200 sensor have an output in the form of RGB frequency values and are processed back into gray frequencies. Then, the PH meter SKU SEN0161 sensor generates a PH value in the urine sample. The results of these checks are displayed on a 16x2 LCD display. The examination results of this tool are compared with the results of the analysis of experts from the Yogyakarta Health Laboratory Center, Urology section. and get an accuracy level of 93% with the success of the data as much as 28 of the 30 data taken.
Single Exponential Smoothing-Multilayer Perceptron Untuk Peramalan Pengunjung Unik Jurnal Elektronik
Authors: Ferdinand Miftakhul Anggita Bima , Wibawa Aji Prasetya , Zaeni Ilham Ari Elbaith , Rosyid Harits Ar
Published: December 2021

Jumlah kunjungan rerata pengunjung unik per hari pada jurnal elektronik menunjukkan bahwa hasil terbitan karya ilmiah website tersebut menarik. Sehingga jumlah pengunjung unik dijadikan indikator penting dalam mengukur keberhasilan sebuah jurnal elektronik untuk memenuhi perluasan, penyebaran dan percepatan sistem akreditasi jurnal. Pengunjung Unik merupakan jumlah pengunjung per Internet Address (IP) yang mengakses sebuah jurnal elektronik dalam kurun waktu tertentu. Terdapat beberapa metode yang biasa digunakan untuk peramalan, diantaranya adalah Multilayer Perceptron (MLP).Â Â Kualitas data berpengaruh besar dalam membangun model MLP yang baik, karena sukses tidaknya permodelan pada MLP sangat dipengaruhi oleh data input. Salah satu cara untuk meningkatkan kualitas data adalah dengan melakukan smoothing pada data tersebut. Pada penelitian ini digunkan metode peramalan Multilayer Perceptron berdasarkan penelitian sebelumnya dengan kombinasi data training dan testing 80%-20% dengan asitektur 2-1-1 dan learning rate 0,4. Selanjutnya untuk meningkatkan kualitas data dilakukan smoothing dengan menerapkan metode Single Exponential Smoothing. Dari penelitian yang dilakukan diperoleh hasil terbaik menggunakan alpha 0.9 dengan hasil akurasi MSE 94.02% dan RMSE 75.54% dengan lama waktu eksekusi 580,27 detik.Â The number of visits by the average unique visitor per day on electronic journals shows that the published scientific papers on the website are interesting. So that the number of unique visitors is used as an important indicator in measuring the success of an electronic journal to meet the expansion, dissemination and acceleration of the journal accreditation system. Unique Visitors is the number of visitors per Internet Address (IP) who access an electronic journal within a certain period of time. There are several methods commonly used for forecasting, including the Multilayer Perceptron (MLP). Data quality has a big influence in building a good MLP model, because the success or failure of modeling in MLP is greatly influenced by the input data. One way to improve data quality is by smoothing the data. In this study, the Multilayer Perceptron forecasting method was used based on previous research with a combination of training data and testing 80% -20% with a 2-1-1 architecture and a learning rate of 0.4. Furthermore, to improve data quality, smoothing is done by applying the Single Exponential Smoothing method. From the research conducted, the best results were obtained using alpha 0.9 with MSE accuracy of 94.02% and RMSE 75.54% with a long execution time of 580.27 seconds.
Identifikasi masalah kesehatan masyarakat di Desa Banguntapan melalui Data Program Indonesia Sehat Pendekatan Keluarga (PIS-PK)
Authors: Solikhah Solikhah , Nuraisyah Fatma , Ruliyandari Rochana
Published: December 2021

Noncommunicable diseases and chronic diseases, such as stroke, hypertension and diabetes mellitus has widely founded in Yogyakarta. In order to, the government has developed a health promotion strategy is the healthy Indonesia through a family program approach or Program Indonesia Sehat dengan Pendekatan Keluarga (PIS-PK). The study aimed to analysis determinant factors of public health problems, to obtain of the health situation and public health service in Ponegaran Hamlet, Banguntapan, Bantul. Descriptive research used to interview instruments as 149 respondents. The analysis method used to determine the priority of health problems is Urgency, Seriousness, Growth(USG). Base on three indicators of PIS-PK which were the main problems were the number of family members who smoker (53%), hypertension who did not take regular medication (71%) and health insurance (34%).
The impact of COVID-19 on practice learning in nurse education
Authors: Bliss Julie
Published: December 2021

The COVID-19 pandemic has impacted healthcare education and delivery, including both theory and practice learning. Academic staff responded rapidly to move teaching online during the first lockdown, with many returning to practice to deliver care or upskill practice staff to work in critical care. Many pre-registration students responded by becoming paid NHS employees, contributing to care delivery while remaining on their programme of study. Practice learning partners, despite the challenges of the pandemic, continued to support students to achieve their registration status. This occurred within the context of the Emergency and Recovery Standards, published by the Nursing and Midwifery Council between March 2020 and September 2021. This paper sets out the response of students, practice learning partners and higher education institutions involved in pre-registration nursing and midwifery programmes.
The changing context of advanced practice nursing within the UK community care setting
Authors: Hill Barry , Diamond-Fox Sadie , Mitchell Aby
Published: December 2021

Advanced practice nursing (APN) roles have developed partly to address demand and workforce issues. In community care settings and general practice, an advanced nursing practitioner is generally understood to mean a nurse who has undertaken additional education and training in clinical assessment, including history-taking and physical examination, clinical reasoning and independent prescribing, so they can safely manage patients presenting with undifferentiated and undiagnosed conditions. Capabilities in the Skills for Health framework cover everything from communication and consultation skills, practising holistically and personalised care, to working with colleagues and in teams. The framework is intended to ensure advanced nursing practitioners work to an advanced level. It is also designed to support them to demonstrate and evidence their capabilities to service commissioners, employers, people accessing healthcare and the public.
Autism: making reasonable adjustments in healthcare
Authors: Haydon Clair , Doherty Mary , Davidson Ian A
Published: December 2021

The accompanying article set out why it is important to identify autistic people and the negative consequences of not recognising or understanding autism, including more severe illness and premature death. This article sets out what clinicians can do to help reduce those negative consequences by making ‘reasonable adjustments’ in any healthcare service in which they work.
espaços de uso da teoria: uma cartografia inicial das revistas científicas de Comunicação
Authors: Martino Luis Mauro Sá
Published: December 2021

Este artigo delineia algumas condições de circulação da produção científica em Comunicação nos periódicos da Área. A partir do estudo das temáticas, distribuição geográfica e cronológica e normas de 52 revistas de PPGs ou associações de pesquisa foram observados três pontos: (1) as publicações se apresentam como espaço de formação do capital científico; (2) 82% discutem interfaces da comunicação com outras áreas, em ampla diversidade de assuntos; (3) apenas 17% abrem espaço para a publicação por outras titulações além de doutores. Discutem-se esses resultados a partir de uma perspectiva epistemológica.
ITINERÁRIO TERAPÊUTICO DE PESSOAS COM DIABETES MELLITUS TIPO 2 QUE SOFRERAM AMPUTAÇÃO DE MEMBRO INFERIOR: EXPERIÊNCIA DO ADOECIMENTO
Authors: Martins Luana Ramalho , Bisio Mattos Marina , Silva Diercks Margarita
Published: December 2021

Introdução: O Diabetes Mellitus tipo 2 (DM2) é causa de diversas complicações, entre elas, o pé diabético e a amputação de membro inferior. As complicações do pé diabético são responsáveis por 40% a 70% do total de amputações não-traumáticas de membros inferiores na população geral, sendo grande parte dessas evitáveis através do controle glicêmico da avaliação periódica dos pés das pessoas com DM2. Aqui, questiona-se quais os caminhos que levaram os usuários com complicações relativas à DM2 a terem seus membros amputados. Utilizamos o itinerário terapêutico para entender a experiência do adoecimento dessas pessoas. Objetivo: Conhecer o itinerário terapêutico com foco nas experiências de adoecimento de usuários da Atenção Primária à Saúde que sofreram amputação do membro inferior decorrente de complicações do DM2. Metodologia: Pesquisa qualitativa do tipo estudo de caso com participantes diabéticos com amputação de membro inferior e em acompanhamento em Unidades Básicas de Saúde. Foram revisados os prontuários de cada paciente e realizadas entrevistas semi-estruturadas, categorizadas e analisadas utilizando a análise temática. Resultados/discussão: Os resultados demonstraram experiências singulares, marcadas pelo sofrimento, cronicidade e gravidade da DM2, dificuldade em mudar hábitos enraizados e mudanças corporais e cotidianas ligadas a amputação do membro. Considerações finais: O cuidado integral das pessoas com DM2 se faz necessário, assim como abordagens motivacionais e prevenção das complicações. Todos estes aspectos são experienciados de forma singular por cada pessoa e precisam ser conhecidos pelos profissionais para oferecer um cuidado de qualidade.
HÁBITOS E HIPERTENSÃO: ESTUDO REALIZADO EM HIPERTENSOS DOS SERVIÇOS PÚBLICOS DE SAÚDE EM FEIRA DE SANTANA - BA
Authors: Santos Carvalho Silas , Rodrigues de Oliveira Bruno
Published: December 2021

Introdução: Atualmente a hipertensão é um dos maiores problemas de saúde pública, reconhecida como grave fator de risco para as doenças cardiovasculares e co-responsável importante para as causas de óbito. Novas abordagens e produção de conhecimentos adicionais fazem-se oportunos e necessários, de modo a se obter maior controle dessa doença de impacto no campo da saúde pública. Objetivo: estimar o efeito do estilo de vida em indivíduos hipertensos atendidos em serviços públicos de saúde em Feira de Santana, Bahia. Materiais e Métodos: Estudo caso controle conduzido em indivíduos com idade mínima de 18 anos, atendidos em serviços de saúde pública no município de Feira de Santana, Bahia. O grupo caso foi formado pelos indivíduos com hipertensão, e os controles, por aqueles sem a doença. A coleta de dados foi realizada através de aplicação de questionário estruturado, consulta de prontuários e exame físico. A análise descritiva das variáveis de interesse empregou o teste Qui-quadrado de Pearson e teste T de Student, com significância de 5%. Resultados: Obteve-se uma amostra de 870 indivíduos (585 casos e 285 controles), com média de idade de 52,8 anos, a maioria dos hipertensos era do sexo masculino, com mais de 4 anos de estudo, residentes na zona urbana, não praticantes de atividade física, não fumantes e não etilistas. Conclusão: A aplicação da mudança do estilo de vida em indivíduos hipertensos tem efeito significativo e é indispensável, pois contribui com ações de intervenção efetivas na prevenção e tratamento do público atendido em unidades básicas de saúde.
VARIÁVEIS ASSOCIADAS À MORTALIDADE MATERNO E INFANTIL: UMA REVISÃO INTEGRATIVA
Authors: Martins Ingra Pereira Monti , Nakamura Cristiane Yumi , Carvalho Deborah Ribeiro
Published: December 2021

Introdução: A mortalidade materna e infantil reflete a situação sanitária e a qualidade da assistência à saúde. As taxas de mortalidade no Brasil apresentam diferenças entre as regiões geográficas e são superiores às de outros países em desenvolvimento. Objetivo: Compreender variáveis associadas à mortalidade materna e infantil. Materiais e Métodos: Revisão integrativa, consultadas as bases Literatura Latino-Americana e do Caribe em Ciências da Saúde, Medical Literature Analysis and Retrieval System Online e Banco de Dados em Enfermagem. Considerados artigos publicados entre 1999-2018, cenário Brasil e idioma português, selecionados por dois pesquisadores calibrados com nível de concordância Kappa substancial. As variáveis associadas significativamente às mortalidades foram aproximadas às camadas do modelo dos Determinantes Sociais de Saúde. Resultados: Identificou-se 522 artigos e selecionados 74. Por camada, destacaram-se as variáveis: características individuais - peso ao nascer e idade materna; estilo de vida - tabagismo na gestação; influências sociais - estado civil materno; condições de vida e trabalho - assistência pré-natal e escolaridade materna; condições socioeconômicas e ambientais gerais - saneamento básico e renda. Conclusões: As variáveis mais encontradas foram peso ao nascer e idade materna, aproximadas à camada individual, de baixa governabilidade direta do gestor. Para mudanças nessa camada, as intervenções devem influenciar nas variáveis das camadas mais externas, das quais destacaram-se assistência pré-natal, escolaridade materna, renda e saneamento básico. Reforça-se a responsabilidade direta dos gestores na redução da mortalidade materna e infantil, por meio de ações que visem reduzir as iniquidades em saúde.
Editorial
Authors: Bhat Anil K
Published: December 2021

It is heartening to see the decline of the current pandemic which has taken a significant toll of our work, health and other valuable resources as we limp back to normalcy.
The editorial team of the JKOA has been working tirelessly to bring new information in Orthopaedics and with this issue, we continue the endeavour to showcase the good work done by our members. It has been a privilege for the editorial team to serve KOA and with immense pride and responsibility as we present this new issue for the members. We congratulate the authors for their innovative scientific work presented in this issue.
Scientific research and publication entirely stands on the honesty and integrity of the authors and the editorial teams of journals worldwide invariably are dependent on the sense of trust in their presumed ethical study. It is a matter of great concern to see an increasing frequency of misconduct in scientific publishing which include various forms of plagiarism, Salami slicing, manipulation of authorship and bias based on presence of potential conflict of interest.
Duplicate publication is one such example where the authors submit their papers to multiple journal at the same time. The authors withdraw their manuscript as soon it is accepted in another journal. This appalling act amounts to disrespect for rules, guidelines and above all the ethics of publication. It results in loss of precious time and resources for the journal editors, reviewers associated with issues related to copyright. The authors should be aware that the journals frequently communicate with each on ethical issues and a failed response from the authors or their institution could jeopardise their paper. Our journal follows the COPE guidelines diligently which clearly mentions the problems and solutions related to duplicate submissions. Many of the journals state in their information for authors including that of ours, that dual submission is unethical and subject to automatic rejection.
In recent time
Primary Synovial Chondromatosis of Elbow: A Bowl Full of Tumors
Authors: Jamal P K Ansahe , Pai G Mithun , Acharya Ashwath M , Bhat Anil K
Published: December 2021

Synovial osteochondromatosis is a disease of the synovium characterized by the formation of multiple cartilaginous bodies. The disease is characteristically monarticular, most commonly involving the knee. Despite frequent mention of elbow involvement in various texts and articles, we wish to review the clinical, radiologic, and histologic features of synovial osteochondromatosis of the elbow by presenting a case in an elderly male. By correct preoperative diagnosis and complete excision, full range of motion can be achieved in an relatively unforgivable elbow joint even with a delayed presentation.
Keywords: Loose bodies, Elbow, Synovial
Tunable and enhanced Goos–Hänchen shifts in a monolayer graphene-based metallic grating structure
Authors: Hong Ye , Li Zhengyang , Zhang Changwei , Da Haixia
Published: December 2021

The Goos–Hänchen (GH) effect, a lateral displacement of the reflection beam, enables rich applications in sensors and detectors. Metallic grating structures have gained great attention due to their unique properties, such as enhanced optical transmission and surface enhanced Raman scattering. Here, instead of using the dielectric grating, we demonstrate an enhanced GH shift in the structure with the metallic grating layer, monolayer graphene, dielectric spacer, and metallic substrate. We find that the amplitude of the GH shift is as high as 3616 times of the incident wavelength at the specific working frequency. This enhancement can be understood from the generation of the coupled surface plasmon polaritons between two surfaces of the dielectric space layer. Furthermore, we show efficient control of the GH shift by modulating the geometric parameters of the proposed structure and chemical potential of the monolayer graphene. Our result establishes an alternative metallic grating structure for tunable and enhanced GH shifts in graphene-based nanostructures.
Photonic bandgap terahertz fibers based on honeycombed tubes
Authors: Lu Dunke , Wan Minggui , Li Zhiwei , Huang Shihong , Zhang Wu , Li Baicheng , Lu Xinglian , Li Xiaohang , Fang Xiaohui
Published: December 2021

Terahertz fibers are highly applicable for short-haul stable terahertz transmissions, and thus have potential use in upgrading terahertz systems. In this paper, a photonic crystal structure consisting of honeycombed tubes is proposed. Numerical studies based on the plane wave expansion method demonstrate that, in comparison to the photonic crystal consisting of honeycombed airholes or triangulated tubes, the one proposed in this paper can deliver a broader and less dispersive bandgap, which has been further confirmed by another calculation based on the finite element method. Then a fiber structure is designed to perform the single mode guidance for a broad spectrum of terahertz waves. The second derivative of mode effective area is introduced to define the effective guiding spectrum for the bandgap terahertz fiber. Mode calculations are performed by use of the finite element method, in which the imaginary part of material refractive index is directly took into account. Obtained results show that the designed fiber suffers low transmission losses over a broad spectrum centered at 1 terahertz. Further, an optimized design is worked out to exhibit the lowest loss for the frequency of 1 terahertz, coming up to 0.3 dB/cm. Not only that, this design can also provide nearly zero flat dispersions with |β2| 1 ps2/cm over 0.81-1.12 terahertz, as well as negligible bending induced losses (< 10−11 dB/cm) for bending radii larger than 1 cm , indicative of a good transmission characteristic for terahertz pulses. Finally, we discuss possible fabrication methods on the proposed fiber.
Shaping autofocusing Airy beams through the modification of Fourier spectrum
Authors: Xu Danlin , Liu Yujun , Mo Zhenwu , Jiang Junjie , Shi Jingyi , Liang Zehong , Wu You , Zhao Jiajia , Yang Haobin , Huang Haiqi , Liu Hongzhan , Shui Lingling , Deng Dongmei
Published: December 2021

A new type of Airy beam arisen from the modification of Fourier spectrum is introduced numerically and experimentally. The autofocusing Airy beam (AAB) exhibits the features of off-axis autofocusing and transverse self-accelerating, producing a needle-like focus in the longitudinal direction and a tiny focal spot at the focusing plane. Furthermore, the focusing properties such as focusing position, focal spot size, focusing intensity and depth of focus can be adjusted by modulating parameters of the AAB. Experimental demonstrations of particle trapping and manipulation with the AAB are also presented. The number of trapped particles can be controlled by changing the focal spot size at the autofocusing plane. Our results offer practical applications in particle manipulation, fluorescent imaging technology, laser spectroscopy and so on.
Single-shot pixel super-resolution phase imaging by wavefront separation approach
Authors: Kocsis Peter , Shevkunov Igor , Katkovnik Vladimir , Rekola Heikki , Egiazarian Karen
Published: December 2021

We propose a novel approach for lensless single-shot phase retrieval, which provides pixel super-resolution phase imaging. The approach is based on a computational separation of carrying and object wavefronts. The imaging task is to reconstruct the object wavefront, while the carrying wavefront corrects the discrepancies between the computational model and physical elements of an optical system. To reconstruct the carrying wavefront, we do two preliminary tests as system calibration without an object. Essential for phase retrieval noise is suppressed by a combination of sparse- and deep learning-based filters. Robustness to discrepancies in computational models and pixel super-resolution of the proposed approach are shown in simulations and physical experiments. We report an experimental computational super-resolution of 2μm, which is 3.45× smaller than the resolution following from the Nyquist-Shannon sampling theorem for the used camera pixel size of 3.45μm. For phase bio-imaging, we provide Buccal Epithelial Cells reconstructed with a quality close to the quality of a digital holographic system with a 40× magnification objective. Furthermore, the single-shot advantage provides a possibility to record dynamic scenes, where the frame rate is limited only by the used camera. We provide amplitude-phase video clip of a moving alive single-celled eukaryote.
100 MHz frequency-spacing switchable single-dual-frequency laser based on MXene QDs and a phase-shifted FBG
Authors: Qiao Wen , Feng Zhu
Published: December 2021

This paper introduces a mode-hop-free switchable single-dual-frequency fiber laser based on Ti2C MXene quantum dots and a phase-shifted fiber Bragg grating that exhibits two single-frequency operating states and one dual-frequency operating state for the first time. In our experiments, this laser has a threshold as low as 6 mW, a narrowest linewidth of 473.5 Hz, a relative intensity noise of −101.5 dB/Hz, an optical signal-to-noise ratio over 83 dB, and a slope efficiency that reaches 2.2% as a single-frequency fiber laser. Compared with other congeneric lasers, it has the best performance in terms of the threshold and signal to noise ratio. An easily detectable beat frequency of 122 MHz was measured when the laser was switched to be a dual-frequency fiber laser. This switchable single-dual-frequency fiber laser has the potential to be applied as a Lidar source for the measurement of static targets and moving subjects.
Taper-in-taper fiber structure-based LSPR sensor for alanine aminotransferase detection
Authors: Wang Zhi , Singh Ragini , Marques Carlos , Jha Rajan , Zhang Bingyuan , Kumar Santosh
Published: December 2021

Alanine aminotransferase (ALT), a critical component of human blood, is inextricably associated with liver injury. The current study develops a novel biosensor based on the localized surface plasmon resonance (LSPR) principle for the detection of ALT analytes at concentrations ranging from 0 to 1000 Units per liter (U/L). According to the authors' knowledge, this is the first time an optical fiber structure with a taper-in-taper structure has been developed for biosensing applications. It is fabricated using the three-electrode semi-vacuum taper technique and is characterized using a combiner manufacturing system. Gold nanoparticles (AuNPs), molybdenum disulfide nanoparticles (MoS2-NPs), and cerium oxide nanoparticles (CeO2-NPs) are immobilized on the sensing region to improve the sensing performance. Prior to application, these nanoparticles are characterized using a high-resolution transmission electron microscope (HR-TEM) and a UV-Visible spectrophotometer. AuNPs promote the LSPR phenomenon, whereas MoS2-NPs/CeO2-NPs contribute to the sensor probe's biocompatibility and stability. Following that, the probe surface was functionalized with glutamate oxidase (GluOx) to improve selectivity. The probe demonstrated an excellent linear relationship with the subsequent assay's ALT concentration. Additionally, the probe's performance characteristics such as reusability, reproducibility, stability, and selectivity are evaluated in order to determine its clinical utility in diagnosing liver injury.
All-silicon multi-band TM-pass polarizer on a 220 nm SOI enabled by multiplexing grating regimes
Authors: Zhang Jinsong , Xu Luhua , Mao Deng , D’Mello Yannick , Li Weijia , Lessard Stephane , Plant David V.
Published: December 2021

We propose an all-silicon design of a multi-band transverse-magnetic-pass (TM-pass) polarizer. The device is based on one-dimensional gratings that work under different regimes that depend on the polarization. With a tapered structure, it is revealed that the operation bandwidth can be extended by multiplexing the diffraction in O-band and the reflection in S-, C-, and L-bands for the transverse-electric (TE) mode. By simulation, we achieve a 343 nm device bandwidth with insertion loss (IL) < 0.4 dB and polarization extinction ratio (PER) > 20 dB. The operation wavelength range covers commonly-used optical telecommunication bands including the O-, S-, C-, and L- bands. Experimental results also show IL < 1.6 dB and PER > 20 dB from 1265 nm to 1360 nm corresponding to the O-band, and from 1500 nm to 1617 nm that corresponds to the C-band. The device is a single-etched design on the standard 220 nm silicon-on-insulator (SOI) with silicon oxide cladding. Such a simple and compatible design paves the way for developing practical multi-band silicon photonic integrated circuits.
SESAM mode-locked Yb:SrLaAlO4 laser
Authors: Zeng Huang-Jun , Lin Zhang-Lang , Xue Wen-Ze , Zhang Ge , Pan Zhongben , Lin Haifeng , Loiko Pavel , Mateos Xavier , Petrov Valentin , Wang Li , Chen Weidong
Published: December 2021

We report on a detailed investigation of continuous-wave and SESAM mode-locked (ML) laser operation of an Yb:SrLaAlO4 laser. Pumped with a high-brightness fiber laser at 976 nm, the ML Yb:SrLaAlO4 laser delivered soliton pulses as short as 38 fs at 1071 nm with an average output power of 86 mW and a pulse repetition rate of ∼59 MHz. The maximum average output power reached 1.05 W at 1054 nm for longer pulses (94 fs), corresponding to a peak power of 146 kW and an optical efficiency of 38.6%. To the best of our knowledge, this is the first demonstration of SESAM ML operation of the Yb:SrLaAlO4 laser.
Backlight system using an interleaved Fresnel lens array that attains a uniform luminance and two-dimensional directional light control
Authors: Borjigin Garimagai , Kakeya Hideki
Published: December 2021

A novel (to the best of our knowledge) Fresnel lens array is proposed
to realize a uniform directional backlight with two-dimensional
directionality. Autostereoscopic display with the proposed lens array
improves image output quality and relieves the viewer’s posture
restriction without the need for any additional eye aid. In the
proposed lens array, tiny prisms composing two adjacent linear Fresnel
lenses are interleaved so that the two lenses may be virtually
overlapped and work independently. The widths of the elemental prisms
vary depending on the distance from the center of each lens. Thus, the
light passing through the two lenses is mixed, which results in higher
and more uniform luminance intensity. A prototype of an
autostereoscopic display based on the time-multiplexed directional
backlight method and made with the proposed lens array attained
uniform luminance as well as low cross–talk between left-eye
and right-eye images.