bluuebunny/crossref_metadata_2025 huggingface dataset:
An Optimal Method of Energy Management for Regional Energy System with a Shared Energy Storage
Authors: Jiao Xianan , Wu Jiekang , Mao Yunshou , Luo Weiming , Yan Mengxuan
Published: January 2023

The regional energy system (RES) is a system that consumes multiple forms of energy in the region and achieves coordinated and efficient utilization of energy resources. The RES is composed of multiple micro energy systems (MESs); however, due to the mismatch of energy resources and different energy consumption within each MES, a large amount of clean energy is wasted, and each MES has to acquire extra energy. This significantly increases operation costs and contributes to environmental pollution. One of the promising ways to solve this problem is to deploy an energy storage system in the RES, which can make use of its advantages to transfer energy in space-time and fulfill the demand for loads in different periods, and conduct unified energy management for each MES in the RES. Nevertheless, a large number of users are deterred by the high investment in energy storage devices. A shared energy storage system (SESS) can allow multi-MESs to share one energy storage system, and meet the energy storage needs of different systems, to reduce the capital investment of energy storage systems and realize efficient consumption of clean energy. Taking multiple MESs as the object, this paper proposes a model and collaborative optimal strategy of energy management for the RES to accomplish high utilization of clean energy, environmental friendliness, and economy. First, the paper analyzes the internal energy supply characteristics of the RES and develops a model of the RES with an SESS. Then, the paper poses the management concept of load integration and unified energy distribution by using the operational information of each subsystem. An optimal operation strategy is established to minimize daily operation costs and achieve economic, environmentally friendly, and efficient operation of the RES. Third, by setting up scenarios such as no energy storage system and an independent energy storage system (IESS) of each MES and SESS, a case of a science and education park in Guangzhou, China, is illustrated for experiments. Numerical experiment results show that with an SESS built by the investor in the RES and applying the mentioned energy management strategy, the utilization of clean energy can be 100%, the operation costs can be reduced by up to 9.78%, the pollutant emission can be reduced by 3.92%, and the peak-to-valley difference can be decreased by 20.03%. Finally, the influence of energy storage service fees and electricity tariffs on daily operation costs is discussed, and the operation suggestions of the SESS are proposed. It validates the effectiveness of the proposed strategy.
Preparation and Numerical Optimization of TiO2:CdS Thin Films in Double Perovskite Solar Cell
Authors: Nowsherwan Ghazi Aman , Zaib Aurang , Shah Aqeel Ahmed , Khan Mohsin , Shakoor Abdul , Bukhari Syed Nizamuddin Shah , Riaz Muhammad , Hussain Syed Sajjad , Shar Muhammad Ali , Alhazaa Abdulaziz
Published: January 2023

This work focuses on preparing TiO2, CdS, and composite TiO2:CdS thin films for photovoltaic applications by thermal evaporation. The suggested materials exhibit very good optical and electrical properties and can play a significant role in enhancing the efficiency of the device. Various microscopy and spectroscopy techniques were considered to investigate the optical, morphological, photoluminescence, and electrical properties. FTIR confirms the material identification by displaying some peaks in the fingerprint region. UV Vis spectroscopy yields high transmission (80–90%) and low absorbance (5–10%) within the spectral region from 500 nm to 800 nm for the composite thin films. The optical band gap values for CdS, TiO2, and TiO2:CdS thin films are 2.42 eV, 3.72 eV, and 3.6 eV. XRD was utilized to analyze the amorphous nature of the thin films, while optical and SEM microscopy were employed to examine the morphological changes caused by the addition of CdS to TiO2. The decrease in the bandgap of the composite thin films was determined by the Tauc plot, which is endorsed due to the band tailing effects. Photoluminescence spectroscopy depicts several emission peaks in the visible region when they are excited at different wavelengths, and the electrical measurement enhances the material conductivity. Furthermore, the proposed electron transport materials (TiO2, CdS, TiO2:CdS) were simulated with different perovskite materials to validate their design by employing the SCAPS-1D program and assess their performance in commercial implementation. The observed results suggest that TiO2:CdS is a promising candidate to be used as an ETM in PSC with enhanced productivity.
Research on Model Calibration Method of Chiller Plants Based on Error Reverse Correction with Limited Data
Authors: Zhen Cheng , Niu Jide , Tian Zhe
Published: January 2023

Model-based optimization is an important means by which to analyze the energy-saving potential of chiller plants. To obtain reliable energy-saving results, model calibration is essential, which strongly depends on operating data. However, sufficient data cannot always be satisfied in reality. To improve the prediction accuracy of the model with limited data, a model calibration method based on error reverse correction was investigated. A traditional optimization-based calibration method was first used for preliminary model calibration to obtain simulation data and simulation errors. Then, the sources of the simulation errors were analyzed to determine the distribution characteristics of the corresponding operating conditions of the model. Finally, the performance of the model was reversely corrected by adding a correction term to the original model. The proposed calibration method was tested on a chiller plant in Xiamen, China. The results showed that the proposed calibration method improved prediction accuracy by 2.61% (the coefficient of variation of the root mean square error (CV (RMSE)) was reduced from 3.96% to 1.35%) compared to the traditional method. The maximum mean bias error (MBE) for monthly chiller energy consumption was 2.66% with the proposed calibration method, while it was 10.42% with the traditional method. Overall, in scenarios with limited data, the proposed calibration method can effectively improve the accuracy of simulation results.
Redactable Blockchain: Comprehensive Review, Mechanisms, Challenges, Open Issues and Future Research Directions
Authors: Abd Ali Shams Mhmood , Yusoff Mohd Najwadi , Hasan Hasan Falah
Published: January 2023

The continuous advancements of blockchain applications impose constant improvements on their technical features. Particularly immutability, a highly secure blockchain attribute forbidding unauthorized or illicit data editing or deletion, which functions as crucial blockchain security. Nonetheless, the security function is currently being challenged due to improper data stored, such as child pornography, copyright violation, and lately the enaction of the “Right to be Forgotten (RtbF)” principle disseminated by the General Data Protection Regulation (GDPR), where it requires blockchain data to be redacted to suit current applications’ urgent demands, and even compliance with the regulation is a challenge and an unfeasible practice for various blockchain technology providers owing to the immutability characteristic. To overcome this challenge, mutable blockchain is highly demanded to solve previously mentioned issues, where controlled and supervised amendments to certain content within constrained privileges granted are suggested by several researchers through numerous blockchain redaction mechanisms using chameleon and non-chameleon hashing function approaches, and methods were proposed to achieve reasonable policies while ensuring high blockchain security levels. Accordingly, the current study seeks to thoroughly define redaction implementation challenges and security properties criteria. The analysis performed has mapped these criteria with chameleon-based research methodologies, technical approaches, and the latest cryptographic techniques implemented to resolve the challenge posed by the policy in which comparisons paved current open issues, leading to shaping future research directions in the scoped field.
Cost-Profiling Microservice Applications Using an APM Stack
Authors: de Vries Sjouke , Blaauw Frank , Andrikopoulos Vasilios
Published: January 2023

Understanding how the different parts of a cloud-native application contribute to its operating expenses is an important step towards optimizing this cost. However, with the adoption and rollout of microservice architectures, the gathering of the necessary data becomes much more involved and nuanced due to the distributed and heterogeneous nature of these architectures. Existing solutions for this purpose are either closed-source and proprietary or focus only on the infrastructural footprint of the applications. In response to that, in this work, we present a cost-profiling solution aimed at Kubernetes-based microservice applications, building on a popular open-source application performance monitoring (APM) stack. By means of a case study with a data engineering company, we demonstrate how our proposed solution can provide deeper insights into the cost profile of the various application components and drive informed decision-making in managing the deployment of the application.
Transcriptome Analysis of the Immune Process of Golden Pompano (Trachinotus ovatus) Infected with Streptococcus agalactiae
Authors: Gao Jie , Guo Hua-Yang , Liu Ming-Jian , Zhu Ke-Cheng , Liu Bo , Liu Bao-Suo , Zhang Nan , Jiang Shi-Gui , Zhang Dian-Chang
Published: January 2023

The golden pompano (Trachinotus ovatus) is one of the most economically valuable marine fishes in South China. Streptococcus agalactiae, an infectious Gram-positive bacterium that is highly destructive for golden pompano culture, has recently caused massive losses to the golden pompano industry. This study aimed to investigate the dynamic immune response of golden pompano to S. agalactiae infection, using RNA-seq analysis at two different time points after infection. Abundances of differentially expressed genes (DEGs) gradually increased in the liver and spleen 48–120 h post-infection, whereas those in the head kidney were lower at 120 h than at 48 h. Pathway enrichment analysis of DEGs revealed that genes related to the complement system were continuously transcribed between 48 and 120 h. Metabolic and immune-regulation-related pathways were highly enriched in the liver 48 h after infection. Transcriptome analysis was verified using quantitative PCR for eight genes with similar expression trends. This study revealed the inflammatory response of golden pompano after S. agalactiae infection, including inflammation-related chemokines and signaling pathways. Our findings provide a theoretical basis for studying S. agalactiae resistance in golden pompano and provide a reliable resource for the genetic breeding of fish.
Almost Automorphic Strong Oscillation in Time-Fractional Parabolic Equations
Authors: Zhang Tianwei , Li Yongkun , Zhou Jianwen
Published: January 2023

This paper gives some results on almost automorphic strong solutions to time-fractional partial differential equations by employing a mix o thef Galerkin method, Fourier series, and Picard iteration. As an application, the existence, uniqueness, and global Mittag–Leffler convergence of almost automorphic strong solution are discussed to a concrete time-fractional parabolic equations. To the best of our knowledge, this is the first study on almost automorphic strong solutions on this subject.
Impact of FecB Mutation on Ovarian DNA Methylome in Small-Tail Han Sheep
Authors: Xie Lingli , Miao Xiangyang , Luo Qingmiao , Zhao Huijing , Qin Xiaoyu
Published: January 2023

Booroola fecundity (FecB) gene, a mutant of bone morphogenetic protein 1B (BMPR-1B) that was discovered in Booroola Merino, was the first prolificacy gene identified in sheep related to increased ovulation rate and litter size. The mechanism of FecB impact on reproduction is unclear. Methods: In this study, adult Han ewes with homozygous FecB(B)/FecB(B) mutations (Han BB group) and ewes with FecB(+)/FecB(+) wildtype (Han ++ group) were selected. Methylated DNA immunoprecipitation and high-throughput sequencing (MeDIP-seq) was used to identify differences in methylated genes in ovary tissue. Results: We examined differences in DNA methylation patterns between HanBB and Han ++ sheep. In both sheep, methylated reads were mainly distributed at the gene body regions, CpG islands and introns. The differentially methylated genes were enriched in neurotrophy in signaling pathway, Gonadotropin Releasing Hormone (GnRH) signaling pathway, Wnt signaling pathway, oocyte meiosis, vascular endothelial growth factor (VEGF) signaling pathway, etc. Differentially-methylated genes were co-analyzed with differentially-expressed mRNAs. Several genes which could be associated with female reproduction were identified, such as FOXP3 (forkhead box P3), TMEFF2 (Transmembrane Protein with EGF Like and Two Follistatin Like Domains 2) and ADAT2 (Adenosine Deaminase TRNA Specific 2). Conclusions: We constructed a MeDIP-seq based methylomic study to investigate the ovarian DNA methylation differences between Small-Tail Han sheep with homozygous FecB mutant and wildtype, and successfully identified FecB gene-associated differentially-methylated genes. This study has provided information with which to understand the mechanisms of FecB gene-induced hyperprolificacy in sheep.
KIBRA Gene Variant Is Associated with Ability in Chess and Science
Authors: Ahmetov Ildus I. , Valeeva Elena V. , Yerdenova Meruert B. , Datkhabayeva Gaukhar K. , Bouzid Amal , Bhamidimarri Poorna Manasa , Sharafetdinova Liliya M. , Egorova Emiliya S. , Semenova Ekaterina A. , Gabdrakhmanova Leysan J. , Yusupov Rinat A. , Larin Andrey K. , Kulemin Nikolay A. , Generozov Edward V. , Hamoudi Rifat , Kustubayeva Almira M. , Rees Tim
Published: January 2023

The kidney and brain expressed protein (KIBRA) plays an important role in synaptic plasticity. Carriers of the T allele of the KIBRA (WWC1) gene rs17070145 C/T polymorphism have been reported to have enhanced spatial ability and to outperform individuals with the CC genotype in working memory tasks. Since ability in chess and science is directly related to spatial ability and working memory, we hypothesized that the KIBRA T allele would be positively associated with chess player status and PhD status in science. We tested this hypothesis in a study involving 2479 individuals (194 chess players, 119 PhD degree holders in STEM fields, and 2166 controls; 1417 males and 1062 females) from three ethnicities (236 Kazakhs, 1583 Russians, 660 Tatars). We found that frequencies of the T allele were significantly higher in Kazakh (66.9 vs. 55.1%; p = 0.024), Russian (44.8 vs. 32.0%; p = 0.0027), and Tatar (51.5 vs. 41.8%; p = 0.035) chess players compared with ethnically matched controls (meta-analysis for CT/TT vs. CC: OR = 2.05, p = 0.0001). In addition, none of the international chess grandmasters (ranked among the 80 best chess players in the world) were carriers of the CC genotype (0 vs. 46.3%; OR = 16.4, p = 0.005). Furthermore, Russian and Tatar PhD holders had a significantly higher frequency of CT/TT genotypes compared with controls (meta-analysis: OR = 1.71, p = 0.009). Overall, this is the first study to provide comprehensive evidence that the rs17070145 C/T polymorphism of the KIBRA gene may be associated with ability in chess and science, with the T allele exerting a beneficial effect.
Print Materials to Promote Physical Activities in Japan: Content Analysis from a Goal Theory
Authors: Nagasawa Tomomi , Okuhara Tsuyoshi , Terada Marina , Okada Hiroko , Goto Eiko , Kiuchi Takahiro
Published: January 2023

Physical activity has significant health benefits for the heart, body, and mind. However, the percentage of people engaging in exercise routines is low in Japan. Goals are important components of motivation. Scholars suggest that appropriately setting both subordinate goals of what to do and superordinate goals of why to do it may motivate the audience and promote behavior. However, it is not known what goals are presented in print materials that promote physical activity. Therefore, this study aimed to understand the presented goals by performing content analysis of those materials in Japan. We collected print materials such as leaflets, brochures, and posters via website search. The presence of subordinate and superordinate goals and topics for each goal was analyzed. A total of 224 print materials were systematically collected and analyzed. The results showed that 14.3% of the print materials did not present any superordinate goals, whereas 100% of them presented subordinate goals. For superordinate goals, healthy aging was frequently presented. For subordinate goals, 67.4% presented only exercise. There is a difference in presenting goals between the private and government sectors. Since goals affect motivation and behavior change, it may be beneficial to incorporate the findings of the goal theory in future print materials.
Cost-Effectiveness of Sugammadex Versus Neostigmine to Reverse Neuromuscular Blockade in a University Hospital in Taiwan: A Propensity Score-Matched Analysis
Authors: Lan Winnie , Tam Ka-Wai , Chen Jui-Tai , Cata Juan P. , Cherng Yih-Giun , Chou Yun-Yun , Chien Li-Nien , Chang Chia-Li , Tai Ying-Hsuan , Chu Lu-Min
Published: January 2023

Sugammadex has several pharmacological advantages over neostigmine, including faster reversal of neuromuscular blockade and fewer adverse effects. However, the economic impact of sugammadex remains controversial due to the considerable heterogeneity of study designs and clinical settings in previous studies. In a post-hoc analysis of a randomized controlled trial, we evaluated patients who underwent elective surgeries and general anesthesia with endotracheal intubation in a medical center in Taiwan between March 2020 and August 2020. Patients were divided into either the sugammadex or neostigmine group based on the neuromuscular blocking drug used. Propensity score matching was used to balance the baseline patient characteristics between the two groups. The patient’s recovery from anesthesia and the putative cost-effectiveness of sugammadex versus neostigmine was assessed. Derived cost-effectiveness using personnel costs in the operating room and the post-anesthesia care unit was estimated using multiple linear regression models. A total of 2587 and 1784 patients were included before and after matching, respectively. Time to endotracheal extubation was significantly shorter in the sugammadex group (mean 6.0 ± standard deviation 5.3 min) compared with the neostigmine group (6.6 ± 6.3 min; p = 0.0032). In addition, the incidence of bradycardia was significantly lower in the sugammadex group (10.2%) compared with the neostigmine group (16.9%; p < 0.001). However, the total costs were significantly lower in the neostigmine group (50.6 ± 21.4 United States dollars) compared with the sugammadex group (212.0 ± 49.5 United States dollars). Despite improving postoperative recovery, the benefits of sugammadex did not outweigh its higher costs compared with neostigmine, possibly due to the low costs of labor in Taiwan’s healthcare system.
Healthcare Research in Mass Religious Gatherings and Emergency Management: A Comprehensive Narrative Review
Authors: Almehmadi Mater , Alqahtani Jaber S.
Published: January 2023

Religious mass gatherings, especially pilgrimages of various faiths, involve overcrowding and the international movement of people, exposing individuals to significant health risks, such as the spread of infectious diseases, crowds, exposure to bad weather, physical stress, or risks due to pre-existing medical conditions. This paper aims to review the literature related to health care research on religious mass gatherings, with special reference to the role of awareness creation, training, and risk awareness for individuals during Hajj. The results indicated that the research on health risks associated with large-scale gatherings showed that some countries (which witness religious gatherings) follow effective preventive measures to reduce health risks, while some countries did not (and linked this to its poor infrastructure and the low standard of living in it, such as India). It also showed that most studies overlooked identifying the causes of infectious diseases and determining the perceptions of participants in mass gatherings. While it showed that environmental factors strongly influence the emergence of infectious diseases among individuals, the results also showed the scarcity of research that revolves around the awareness of community members, the health risks of mass gatherings, preventive measures against diseases, and the main effects on individuals’ perceptions of risks. The results also showed a lack of research evidence on how pilgrims perceive risks, adopt information, and interact with their willingness to be trained in preventive measures.
Sexuality and Religious Ethics: Analysis in a Multicultural University Context
Authors: Navarro-Prado Silvia , Sánchez-Ojeda María Angustias , Fernández-Aparicio Ángel , Vázquez-Sánchez María Ángeles , Plaza del Pino Fernando Jesús , Alemany-Arrebola Inmaculada
Published: January 2023

Sexuality is still perceived by some cultures as a taboo subject. Although there is now a more open attitude towards sexuality, the maintenance of virginity is one of the most concerning issues in some religions. The aim of this research is to investigate the sexual behavior of university students and analyze how culture and religion influence the beliefs and maintenance of virginity in women and men. A mixed methodology was used, involving 355 students in the quantitative design and 18 informants for the qualitative study who took part in two focus groups. The results indicate that religion and the degree of religious practice are predictor variables for the decision to have penetrative sex, with Muslim women and men giving more importance to the maintenance of a woman’s virginity. However, this hymen-centric view does not prevent other sexual practices, such as oral and/or anal sex, among young people who wish to maintain their virginity until marriage. Religious ethics continue to influence the sexual behavior of young people today. Therefore, nursing education must address these issues to improve the affective sexual health of the population.
Coir-Based Growing Media with Municipal Compost and Biochar and Their Impacts on Growth and Some Quality Parameters in Lettuce Seedlings
Authors: Martins Tiago , Machado Rui , Alves-Pereira Isabel , Ferreira Rui , Gruda Nazim
Published: January 2023

The purpose of this study was to develop substrates with little or no peat by combining coir-based growing media with municipal compost and/or acacia biochar, two locally produced renewable resources, and to assess their effects on lettuce seedling emergence and growth, as well as their content in photosynthetic pigments and total phenols. Two experiments were carried out, the first with six mixes using compost and biochar blended with perlite, pine bark, and blonde peat to adjust some physicochemical characteristics. The mixes of coir: compost: pine bark: blonde peat (73:12:5:10, v/v) and coir: compost: biochar: blonde peat (73:12:10:5, v/v) had physicochemical characteristics closer to or within the normal range of the substrates. The presence of 12% compost and 10% biochar in the mixtures had no adverse effect on lettuce seed germination and cumulative seed emergence, which ranged from 90 to 99%. The seedling growth in those mixes was vigorous and higher than in other mixtures. Coir-based growing media with municipal solid waste compost and compost plus biochar can reduce the use of peat to a percentage of 5–10% v/v and the use of 17–22% v/v of locally produced renewable resources. In addition, mixtures affected the total phenol content in the lettuce leaves. Future research is needed to assess the behavior of seedlings after their transplantation.
The Role of 1-methylcyclopropylene (1-MCP) and Salicylic Acid (SA) in Induced Resistance of Postharvest Fruits
Authors: Meng Xiangzhi , Fang Jiazhen , Fu Maorun , Jiao Wenxiao , Ren Pengfei , Yang Xiaoying
Published: January 2023

Postharvest diseases cause huge postharvest losses of horticultural fresh produce. Cooling and synthetic fungicide are used as traditional postharvest preservation technology. Recently, induced resistance has been thought to be an optional and perhaps alternative preservation technology. 1-methylcyclopropylene (1-MCP) and salicylic acid (SA) are two more common chemical agents used mostly as a preservative for harvested fruit in order to achieve better quality and better taste. Many reports have also proven that 1-MCP and SA could induce postharvest fruit resistance. The purpose of this review is to summarize the role of 1-MCP and SA in postharvest fruit resistance, including the effect of 1-MCP and SA on the induced resistance as well as its involved mechanism; the effects of 1-MCP and SA on firmness, phenolic metabolism, membrane lipid metabolism, and reactive oxygen species in fruit after harvest; and the effects of 1-MCP and SA on disease resistance-related defense enzymes, proteins, signaling synthesis, and signaling pathways as well as the combined effect of 1-MCP and SA on the induced resistance and its mechanism. Meanwhile, we prospect for the future direction of increasing postharvest fruit resistance by 1-MCP and SA in more depth.
Development of the Training Program on Child Abuse Prevention for Citizens (TCAP-C) and Its Effects and Acceptability: Community-Based Participatory Research
Authors: Kita Sachiko , Ochiai Kayoko , Sato Yoichi , Akiyama Saburo , Abe Mitsushiro , Tashita Keiichi , Tanaka Hiroko , Matsumoto Fumiko , Hayashi Shihoko , Kohashi Kosuke , Tsujino Keiichiro , Uchiyama Kentaro , Tsukamatsu Konomi , Ikeda Utako , Ikeda Mari , Suzuki Hidehiro
Published: January 2023

Aim: We developed the Training Program on Child Abuse Prevention for Citizens (TCAP-C) and tested its effects and acceptability among citizen leaders (CLs). Methods: Community-based participatory research using a pretest–posttest follow-up design was conducted in Tokyo, Japan from September 2021 to March 2022. Participants completed questionnaires before, upon completion, and one month and three months after TCAP-C. Recognition, knowledge, and behaviors regarding child abuse and community consciousness were collected and compared before and one and three months after TCAP-C, and the degree of satisfaction, understanding, and meaningfulness were collected upon completion. We analyzed data using repeated-measures ANCOVA. Results: A total of 111, 98, 101, and 94 participants completed the questionnaires before, upon completion, and one and three months after TCAP-C, respectively. Overall, the recognition, knowledge, and community consciousness scores significantly improved from before to one month and three months after TCAP-C. Regarding the behaviors, only the behaviors of learning and watching over were significantly improved from before to one month after TCAP-C; however, those behaviors were not different between before and three months after TCAP-C. Furthermore, 95% participants reported being entirely satisfied with TCAP-C, and 85% and 91% reported good understanding and meaningfulness of the program. Conclusions: TCAP-C is acceptable and can improve CL recognition, knowledge, and community consciousness.
From Zero to Hero: Type 2 Diabetes Mellitus Patients Hike on the Way of St. James—A Feasibility Study with Analyses of Patients’ Quality of Life, Diabetes Distress and Glucose Profile
Authors: Meuffels Frederike Maria , Kempe Hans-Peter , Becker Ulrike , Kornmann Martin , Kress Stephan , Kreutz Thorsten , Brinkmann Christian
Published: January 2023

This study investigates the feasibility of an accompanied 5-day hiking tour (Way of St. James) for type 2 diabetes mellitus (T2DM) patients and its impact on their quality of life/well-being, diabetes distress and glucose profile. Twenty-three T2DM patients (with and without insulin therapy) participated in the study. The 120 km pilgrimage (from Ferrol to Santiago de Compostela, Spain) was accompanied by three physicians, two diabetes counselors and one sports scientist. Quality of life/well-being was assessed by the World Health Organization’s (WHO)-5 questionnaire, and diabetes distress was evaluated based on the Problem Areas in Diabetes (PAID) scale. The glucose levels of six insulin-treated patients were measured using continuous glucose monitoring (CGM) devices, considering that insulin-treated patients can be at increased risk of exercise-induced hypoglycemia. A significant improvement in quality of life/well-being was reported (p < 0.001), while diabetes distress did not change significantly (p = 0.203). Only two of the six insulin-treated patients showed moderate hypoglycemic episodes between 0.97% and 5.21% time below range per day, with glucose levels between 53–70 mg/dL. Hiking tours such as the one organized for this study can improve quality of life/well-being without increasing diabetes distress and are considered relatively safe for T2DM patients, even for those being treated with insulin.
Green Finance, Industrial Structure Upgrading, and High-Quality Economic Development–Intermediation Model Based on the Regulatory Role of Environmental Regulation
Authors: Xu Sheng , Dong Haonan
Published: January 2023

Green finance, as a major policy innovation under the guidance of high-quality economic development, can optimize the economic development mode and structure through green investment to enhance the rationalization and advanced level of industrial structure, and ultimately enhance the level of high-quality development of China’s economy. Based on the panel data of 30 provinces and cities in China from 2009–2019, this study examines the impact of green finance on economic high-quality development and its transmission path using the intermediary model. Based on this, a model with moderated intermediation effects is constructed to explore the mechanism of green finance on an economic high-quality path based on the intermediation path of industrial structure advancement and industrial structure rationalization and the moderated effect of environmental regulation. Finally, regional heterogeneity analysis is conducted. The study found that, firstly, green finance significantly contributes to high-quality economic development, and there is a positive mediating effect of both advanced and rationalized industrial structure. Secondly, environmental regulation positively regulates the positive impact of green finance development on industrial structure upgrading and strengthens the role of industrial structure upgrading in promoting economic quality development, as well as playing a significant positive regulating role in the direct effect of green finance on economic quality development. Finally, there are regional differences in the impact of green finance on high-quality economic development.
Ghana’s Adherence to PASCAR’s 10-Point Action Plan towards Hypertension Control: A Scoping Review
Authors: Sambah Francis , Malau-Aduli Bunmi S. , Seidu Abdul-Aziz , Malau-Aduli Aduli E. O. , Emeto Theophilus I.
Published: January 2023

The continuous increase in the prevalence of hypertension in Ghana has led to various interventions aimed at controlling the disease burden. Nonetheless, these interventions have yielded poor health outcomes. Subsequently, the Pan-African Society of Cardiology (PASCAR), established a 10-point action plan for inclusion in policies to aid control of hypertension. This scoping review assessed the adherence of health policies to the 10-point action plan towards hypertension control/reduction in Ghana. Eight health policies met the inclusion criteria and were assessed. The programme evaluation and policy design framework were used for synthesis and analysis of extracted data. Overall, there was poor adherence to hypertension control observed in the policies. Specifically, there were low levels of integrating hypertension control/reduction measures, a poor task-sharing approach, and poor financial resource allocations to tackle hypertension control/reduction in most of the policies. There was also low support for research to produce evidence to guide future interventions. For Ghana to achieve the global target of reducing hypertension by the year 2025, its health policies must adhere to evidence-based interventions in hypertension management/control. The study recommends a follow-up study among hypertension patients and healthcare professionals to evaluate the factors militating against hypertension management/control in Ghana.
A Qualitative Evaluation of a Health Access Card for Refugees and Asylum Seekers in a City in Northern England
Authors: Moffat Malcolm , Nicholson Suzanne , Darke Joanne , Brown Melissa , Minto Stephen , Sowden Sarah , Rankin Judith
Published: January 2023

Refugees and asylum seekers residing in the UK face multiple barriers to accessing healthcare. A Health Access Card information resource was launched in Newcastle upon Tyne in 2019 by Newcastle City Council, intended to guide refugees and asylum seekers living in the city, and the professional organisations that support them, to appropriate healthcare services provided locally. The aim of this qualitative evaluation was to explore service user and professional experiences of healthcare access and utilisation in Newcastle and perspectives on the Health Access Card. Eleven semi-structured interviews took place between February 2020 and March 2021. Participants provided diverse and compelling accounts of healthcare experiences and described cultural, financial and institutional barriers to care. Opportunities to improve healthcare access for these population groups included offering more bespoke support, additional language support, delivering training and education to healthcare professionals and reviewing the local support landscape to maximise the impact of collaboration and cross-sector working. Opportunities to improve the Health Access Card were also described, and these included providing translated versions and exploring the possibility of developing an accompanying digital resource.
Foam Rolling vs. Proprioceptive Neuromuscular Facilitation Stretching in the Hamstring Flexibility of Amateur Athletes: Control Trials
Authors: Pérez-Bellmunt Albert , Casasayas-Cos Oriol , Ragazzi Paolo , Rodríguez-Sanz Jacobo , Hidalgo-García César , Canet-Vintró Max , Caballero-Martínez Iván , Pacheco Laura , López-de-Celis Carlos
Published: January 2023

Background: the use of stretching techniques in the sports world is frequent and common thanks to their many effects. One of the main benefits of stretching is an increased range of motion (ROM). Recently, the use of a foam roller has spread in sports practice due to benefits that are similar to those of shoes observed in stretching. The objective of the following study was to compare the results of proprioceptive neuromuscular facilitation stretching (PNF) with foam rolling (FR). Methods: The design of the study was a single-blind, randomized controlled trial (clinicaltrial.gov NCT05134883), and the participants were 80 healthy young athletes. The range of motion was evaluated with a modified sit-and-reach test before, during (at 30 s), and at the end of the intervention (at 2 min). The subject’s discomfort sensation was measured using the Borg scale. Effect sizes were calculated using Cohen’s d coefficient. Volunteers were randomized into the PNF group or FR group. Results: the differences were statistically significant (p < 0.001) during the intervention in favor of PNF group. The differences at the end of intervention showed that the PNF group had a greater increase in flexibility, with this difference being statically significant (p < 0.001). The sensation of perceived exertion with PNF at the end of the intervention was similarly classified as moderate for both groups. Conclusion: Despite the fact that the use of FR is spreading in the field of sports and rehabilitation, the results of the present study suggest that the gain in flexibility in the hamstrings is greater if PNF-type stretches are used instead of FR.
Impact of Partnered Pharmacist Medication Charting (PPMC) on Medication Discrepancies and Errors: A Pragmatic Evaluation of an Emergency Department-Based Process Redesign
Authors: Atey Tesfay Mehari , Peterson Gregory M. , Salahudeen Mohammed S. , Bereznicki Luke R. , Simpson Tom , Boland Camille M. , Anderson Ed , Burgess John R. , Huckerby Emma J. , Tran Viet , Wimmer Barbara C.
Published: January 2023

Medication errors are more prevalent in settings with acutely ill patients and heavy workloads, such as in an emergency department (ED). A pragmatic, controlled study compared partnered pharmacist medication charting (PPMC) (pharmacist-documented best-possible medication history [BPMH] followed by clinical discussion between a pharmacist and medical officer to co-develop a treatment plan and chart medications) with early BPMH (pharmacist-documented BPMH followed by medical officer-led traditional medication charting) and usual care (traditional medication charting approach without a pharmacist-collected BPMH in ED). Medication discrepancies were undocumented differences between medication charts and medication reconciliation. An expert panel assessed the discrepancies’ clinical significance, with ‘unintentional’ discrepancies deemed ‘errors’. Fewer patients in the PPMC group had at least one error (3.5%; 95% confidence interval [CI]: 1.1% to 5.8%) than in the early BPMH (49.4%; 95% CI: 42.5% to 56.3%) and usual care group (61.4%; 95% CI: 56.3% to 66.7%). The number of patients who need to be treated with PPMC to prevent at least one high/extreme error was 4.6 (95% CI: 3.4 to 6.9) and 4.0 (95% CI: 3.1 to 5.3) compared to the early BPMH and usual care group, respectively. PPMC within ED, incorporating interdisciplinary discussion, reduced clinically significant errors compared to early BPMH or usual care.
Activity Restriction and Hospitalization in Pregnancy: Can Bed-Rest Exercise Prevent Deconditioning? A Narrative Review
Authors: Palacio Montse , Mottola Michelle F.
Published: January 2023

Evidence suggests that exercise during pregnancy is beneficial to both parent and fetus. However, there are high-risk pregnancy conditions that may warrant hospitalization. In our narrative review, we first describe the clinical implications for activity restriction in pregnancy, the effects of hospitalization, and the impact of bed rest on non-pregnant individuals. We provide examples of a 30 min bed-rest exercise program for hospitalized pregnant patients using the principal of suggested frequency, intensity, time (duration) of activity, and type of activity (FITT) using a resistance tool while in bed. If the individual is able to ambulate, we recommend short walks around the ward. Every minute counts and activity should be incorporated into a program at least 3 times per week, or every day if possible. As in all exercise programs, motivation and accountability are essential. Flexibility in timing of the exercise intervention is important due to the scheduling of medical assessments that may occur throughout the day for these hospitalized patients. Evidence suggests that by improving physical and emotional health through a bed-rest exercise program during a hospitalized pregnancy may help the individual resume demanding daily activity in the postpartum period and improve quality of life once birth has occurred. More research is necessary to improve the health of those individuals who are hospitalized during pregnancy, with follow up and support into the postpartum period.
Effects of Plantar Flexor Stretching on Static and Dynamic Balance in Healthy Adults
Authors: Jung Eui-Young , Jung Jin-Hwa , Cho Hwi-Young , Kim Sung-Hyeon
Published: January 2023

Stretching can affect balance ability by generating biomechanical and physiological changes in the postural muscles. Stretching of the lower extremity muscles can greatly affect posture maintenance strategies and balance ability. However, the relationship between stretching and balance ability has not been clarified. Therefore, this study aimed to investigate the effect of plantar flexor stretching on balance ability. Forty-four healthy young adults were randomly assigned to four groups (static stretching, dynamic stretching, ballistic stretching, and control). Ankle joint range of motion, static balance ability, and dynamic balance ability were evaluated before, immediately after, and 20 min after stretching. Stretching did not affect balance ability in the open-eye condition. After stretching, the sway area was significantly reduced in the closed-eye condition (p < 0.05). After stretching, the reach distance of dynamic balance ability increased significantly (p < 0.05). The results show that plantar flexor stretching can positively affect balance ability. Therefore, plantar flexor stretching should be considered a rehabilitation method to improve balance.
Employee Stock Ownership Plans and Corporate Environmental Performance: Evidence from China
Authors: Sun Hongfeng , Liu Chang
Published: January 2023

In the context of corporate sustainability, studies on the role that managerial incentives play in improving corporate environmental performance have so far focused on incentives provided either to executives and senior managers or to plant managers. However, few studies have considered the role of employee incentives. Drawing on the opportunity provided by the China Securities Regulatory Commission in restarting employee stock ownership plans (ESOPs) in 2014, this paper investigates the impact of employee incentives on environmental performance of high-polluting enterprises. The results indicate that ESOPs are significantly positively related to corporate environmental performance. The positive effect is particularly pronounced in subsamples with weak free-riding problems, high human capital quality, and non-state-owned enterprises (non-SOEs). Further analysis reveals that ESOPs improve corporate environmental performance through enhancing productivity and green technology. Overall, this paper reveals the micro-mechanisms behind the actual effects of employee incentives on corporate environmental management, thus providing timely implications for high-polluting enterprises to improve environmental performance.
“It’s about What You’ve Assigned to the Salad”: Focus Group Discussions on the Relationship between Food and Mood
Authors: Lee Megan F. , Bradbury Joanne F. , Yoxall Jacqui , Sargeant Sally
Published: January 2023

Current observational and interventional studies in nutritional psychiatry suggest that healthy dietary patterns rich in fresh whole foods could protect against depressive symptoms, and that unhealthy dietary patterns high in ultra-processed and refined foods could contribute to depressive symptoms. However, no studies have explored detailed subjective accounts behind the food and mood relationship. This study aimed to uncover unknown factors in the human experience with food and mood. Using a phenomenological framework, this focus group study applied thematic template analysis to accounts of over 50 Australians aged between 18 and 72. Three themes were identified from the transcript of the focus groups: (i) reactive and proactive relationships with food, (ii) acknowledgement of individual diversity relating to eating and mental health, and (iii) improving mood by removing food restriction and eating intuitively. The data highlights the complexity of the relationship between food and mood that extends beyond biological mechanisms which could be used to extend current epidemiological and intervention studies in the field of dietary patterns and depression.
Analysis of the Toll and Spaetzle Genes Involved in Toll Pathway-Dependent Antimicrobial Gene Induction in the Red Flour Beetle, Tribolium castaneum (Coleoptera; Tenebrionidae)
Authors: Kato Daiki , Miura Ken , Yokoi Kakeru
Published: January 2023

Insects rely only on their innate immune system to protect themselves from pathogens. Antimicrobial peptide (AMP) production is the main immune reaction in insects. In Drosophila melanogaster, the reaction is regulated mainly by the Toll and immune deficiency (IMD) pathways. Spaetzle proteins, activated by immune signals from upstream components, bind to Toll proteins, thus, activating the Toll pathway, which in turn, induces AMP genes. Previous studies have shown the difference in immune systems related to Toll and IMD pathways between D. melanogaster and Tribolium castaneum. In T. castaneum, nine Toll and seven spaetzle (spz) genes were identified. To extend our understanding of AMP production by T. castaneum, we conducted functional assays of Toll and spaetzle genes related to Toll-pathway-dependent AMP gene expression in T. castaneum under challenge with bacteria or budding yeast. The results revealed that Toll3 and Toll4 double-knockdown and spz7 knockdown strongly and moderately reduced the Toll-pathway-dependent expression of AMP genes, respectively. Moreover, Toll3 and Toll4 double-knockdown pupae more rapidly succumbed to entomopathogenic bacteria than the control pupae, but spz7 knockdown pupae did not. The results suggest that Toll3 and Toll4 play a large role in Toll-pathway-dependent immune reactions, whereas spz7 plays a small part.
Human Regulatory T Cells: Understanding the Role of Tregs in Select Autoimmune Skin Diseases and Post-Transplant Nonmelanoma Skin Cancers
Authors: Oparaugo Nicole Chizara , Ouyang Kelsey , Nguyen Nam Phuong N. , Nelson Amanda M. , Agak George W.
Published: January 2023

Regulatory T cells (Tregs) play an important role in maintaining immune tolerance and homeostasis by modulating how the immune system is activated. Several studies have documented the critical role of Tregs in suppressing the functions of effector T cells and antigen-presenting cells. Under certain conditions, Tregs can lose their suppressive capability, leading to a compromised immune system. For example, mutations in the Treg transcription factor, Forkhead box P3 (FOXP3), can drive the development of autoimmune diseases in multiple organs within the body. Furthermore, mutations leading to a reduction in the numbers of Tregs or a change in their function facilitate autoimmunity, whereas an overabundance can inhibit anti-tumor and anti-pathogen immunity. This review discusses the characteristics of Tregs and their mechanism of action in select autoimmune skin diseases, transplantation, and skin cancer. We also examine the potential of Tregs-based cellular therapies in autoimmunity.
Anti-Aging Effects of Anthocyanin Extracts of Sambucus canadensis Caused by Targeting Mitochondrial-Induced Oxidative Stress
Authors: Hu Xiaoqing , Yang Yimeng , Tang Shi , Chen Qiuyan , Zhang Meiyu , Ma Jiaoyan , Qin Jianchun , Yu Huimei
Published: January 2023

Anthocyanin is a natural antioxidant agent extracted from the fruits of Sambucus canadensis, which has been considered to have potential anti-aging effects. Cell senescence is the primary cause of aging and related diseases. Recently, research on the development of compounds for eliminating senescent cells or damaged organs have shown prospects. The compounds which promote the clearing of senescent cells are called “senolytics”. Though anthocyanin is considered to have potential anti-aging effects owing to its anti-inflammatory and antioxidant activities, the mechanism of the elimination of senescent cells remains unclear. In this study, we prepared anthocyanins extracted from the fruits of Sambucus canadensis and evaluated their anti-aging effects in vivo and in vitro. We found that anthocyanin could significantly reduce cell senescence and aging of the lens by inhibiting the activity of the PI3K/AKT/mTOR signaling pathway, consequently promoting the apoptosis of senescent cells, increasing the autophagic and mitophagic flux, and enhancing the renewal of mitochondria and the cell to maintain cellular homeostasis, leading to attenuating aging. Therefore, our study provided a basis for anthocyanin to be used as new “senolytics” in anti-aging.