bluuebunny/crossref_metadata_2025 huggingface dataset:
IMPACTO DA CIRURGIA EM MULHERES COM SÍNDROME DOS OVÁRIOS POLICÍSTICOS E COMPLICAÇÕES ENDÓCRINAS
Authors: Jonathan Barbosa Castro
Published: July 2024

A partir de uma revisão de literatura, o objetivo do estudo foi apresentar os mecanismos que causam infertilidade na Síndrome dos Ovários Policísticos (SOP), bem como os tratamentos atuais.  O SOP é conhecido como o distúrbio endócrino mais prevalente na idade fértil, que atinge até 10% das mulheres e causa alterações hormonais, reprodutivas e metabólicas. Portanto, um diagnóstico requer pelo menos dois critérios: oligo-ovulação ou anovulação, hiperandrogenismo clínico ou laboratorial e ovários policísticos detectados por exames ultrassonográficos. De acordo com a avaliação clínica de cada paciente, algumas opções terapêuticas incluem mudanças nos hábitos de vida, como atividade física e dieta saudável, terapia farmacológica, uso de hormônios, fertilização e cirurgia. No entanto, alguns efeitos colaterais do tratamento ainda causam preocupação, como a possibilidade de gestação múltipla, o que requer mais pesquisas para melhorar o prognóstico dessas mulheres.
DESAFIOS NA ABORDAGEM DO PACIENTE COM INSUFICIÊNCIA CARDÍACA NA URGÊNCIA
Authors: Samuel Najjar Abramo Veiga
Published: July 2024

Uma das principais causas de hospitalizações, mortalidade e custos para o sistema de saúde é a insuficiência cardíaca (IC). O número de pacientes com IC avançou aumentou como resultado do aumento da prevalência, melhorias na sobrevivência e envelhecimento da população. O tratamento clínico é difícil para esses pacientes, pois geralmente apresenta sintomas graves e sua qualidade de vida é significativamente prejudicada. Eles também são menos responsivos ou não toleram terapias baseadas em evidências, e apresentam alto risco de hospitalizações de curto prazo e morte. Os resultados são insatisfatórios em pacientes que não são adequados para suporte circulatório mecânico (SCM) ou transplante cardíaco de longo prazo. Além disso, apenas um pequeno número de pacientes com IC avançado deve ser escolhido para terapias avançadas.
Analysis of the concentration and monopolization of production in the economy of the regions
Authors: Dorozhkina Alesya A. ,   O. E. Kutafin Moscow State Law University (MSAL), Russia Moscow
Published: July 2024

Large companies can use advanced technologies, have access to large sales markets and have large financial resources for innovation and development. Concentration and monopolization of production can create problems for competition, innovation and consumers. It is important for the region to find a balance between concentration and monopolization of production, maintain competition in the market, stimulate innovation and development of small and medium-sized enterprises, as well as protect the interests of consumers. Methods of analyzing the level of concentration and monopolization of production make it possible to determine the specialization of the region and the concentration of its enterprises and industries.
The role of the banking sector in the development of the russian nis
Authors: Molchanova Svetlana M. ,   FGAOU HE «Saint-Petersburg State University of Aerospace Instrumentation», Saint-Petersburg, Russia, Myliavin Yackow V. ,   FGAOU HE «Saint-Petersburg State University of Aerospace Instrumentation», Saint-Petersburg, Russia
Published: July 2024

The article reveals the role of the banking sector in the development of the NIS of the Russian Federation. Definitions of the term “national innovation system” are presented, defining the essence of the concept based on various criteria that allow us to highlight the general characteristics of the NIS. Groups of institutions that interact with each other within the framework of the NIS of the Russian Federation are identified. The volume of innovation funding and the share of budgetary funds are graphically presented, reflecting a reduction in government funding and a steady increase in the volume of PPP and private funding. The participation of the banking sector in financial transactions is indicated. We identified shortcomings in the current system of interaction between the institutions of the financial component of the NIS and the feasibility of improving the activities of banks in the development of the national innovation system.
Accounting the features of aviation education in the formation of foresight technologies
Authors: Molchanova Regina V. ,   FGAOU HE «Saint-Petersburg State University of Aerospace Instrumentation», Saint-Petersburg, Russia
Published: July 2024

The article characterizes the features of aviation education in the formation of foresight technologies. The composition of technical and technological features is revealed, reflecting the need to develop in graduates of aviation universities the ability to acquire new knowledge and skills in using information technology in aviation. The formation of universal engineering competencies and applied competencies is noted as an independent direction of the competency-based approach in aviation education to improve the research training of aviation specialists. The author presents in tabular form the relationship between the increasing requirements for the level of preparedness of specialists and the need for continuous improvement through the introduction of e-learning tools and digital technologies in the educational process. The importance of focusing knowledge, skills and individual characteristics on ensuring flight safety is indicated. The article emphasizes the need to maintain the required level of training of aviation specialists, which is implemented through the functioning of the system of continuous professional education created in the industry and developing in modern conditions.
Sustainable Practice of Ifrs And Economic Growth: Evidence From A Case Study on A Developing Country
Authors: Javed Sarfaraz , Nazir Sajjad , Malik Ghulam Mustafa , Khan Azeem Ahmad , Jalil Syed
Published: July 2024

This research aims to investigate whether there is a link between the adoption of International Financial Reporting Standards (IFRS) and the benefits of Foreign Direct Investment (FDI), both of which were significant contributors to Afghanistan's economic growth between 2003 and 2020. This study uses panel integration and causality assessment. It looks into the underlying causes of the problem in terms of short- and long-term partnerships, as well as diversity. The findings of this study support the existence of a positive and significant relationship between the adoption of IFRS and the flow of FDI, as well as the correlation between them. Furthermore, the examination of causes shows that IFRS-related FDI is both a short-term source of EG and a long-term cause of diversification. The analysis of causes demonstrates this. This study investigates Afghanistan and expands on the relationship between IFRS acquisition and FDI income. This research could help developing countries that use IFRS and those that do not use IFRS identify the financial implications of IFRS practices and boost economic growth.
Host Plant Preferences of Butterflies (Lepidoptera: Rhopalocera) in Sriwijaya University Campus of Indralaya, South Sumatra
Authors: APRILLIA INA , LAMIN SYAFRINA , SETIAWAN DONI
Published: July 2024

Hostplants are important for butterflies becaue the plants are where they lay their eggs and catterpilars will to eat    after. A study to about butterflies diversity and their host plant preferences has been carried out in July-September 2014 in Sriwijaya University Campus of Indralaya, South Sumatra. This research was to determine the preferences and identify the various species larval host plants and nectar sources of butterflies in Sriwijaya University Campus of Indralaya. We applied sampling points using purposive sampling method. Our findings suggest that there were 8 larval host plant family Achantaceae, Annonaceae, Cleomaceae, Fabaceae, Lauraceae, Malvaceae, Passifloraceae and Rutaceae. The nectar host plants are 8 Family of plants consisting of Achantaceae, Asteraceae, Loganiaceae, Malvaceae, Oxalidaceae, Passifloraceae, Rubiaceae and Verbenaceae. The highest percentage of host larvae in Family Rutaceae and Achantaceae of 23% and a low of Malvaceae by 7%. The highest nectar host is Family Verbenaceae by 32% and the lowest is Family Loganiaceae with 2%.
STRATEGI PENGEMBANGAN KAWASAN OBJEK WISATA ETNIS TIONGHOA DI TEPIAN SUNGAI MUSI KOTA PALEMBANG
Authors: Budi Dwi Arif Budi Wiyono , Mutaqin Zenal , Agustian Endy
Published: July 2024

Kota Palembang memiliki banyak potensi dalam sektor wisata khususnya di kawasan tepian sungai musi. Kota ini memiliki banyak objek wisata yang memiliki unsur sejarah berdirinya Kota Palembang. Salah satu kawasan yang memiliki objek wisata sejarah di Kota Palembang adalah kawasan Kelurahan 7 dan 10 Ulu Kota Palembang, kawasan objek wisata ini memiliki peninggalan-peninggalan Kerajaan Cina di Kota Palembang. Kawasan objek wisata ini memiliki banyak potensi pada kawasanya yang dapat dikembangkan menjadi daya tarik bagi wisatawan namun masih terdapat beberapa kendala yang dapat menghambat proses pengembangan pada kawasan objek wisatanya. Tujuan penelitian ini yakni untuk menyusun Rencana Strategi Pengembangan Kawasan Objek Wisata Etnis Tionghoa di Tepian Sungai Musi Kota Palembang pada Kelurahan 7 dan 10 Ulu. Penelitian ini menggunakan metode analisis kualitatif dengan melakukan pendekatan fenomenologi. Berdasarkan hasil analisis yang telah dilakukan di peroleh hasil berupa Rumusan Arahan Program Kegiatan Perencanaan Kawasan Pada Kawasan Objek Wisata Etnis Tionghoa di Tepian Sungai Musi Pada Kelurahan 7 dan 10 Ulu Kota Palembang.
IDENTIFIKASI PERSEBARAN SPASIAL UMKM EKONOMI KREATIF DI KABUPATEN PRINGSEWU
Authors: Surya Tri Esthi Wira Hutama
Published: July 2024

Kekayaan sumber daya alam Indonesia menjadikan Indonesia sebagai negara agraris. Salah satunya di Kabupaten Pringsewu dengan kontribusi ekonomi paling besar berasal dari sektor pertanian. Namun pada 5 tahun terakhir, terjadi penurunan kontribusi sektor pertanian terhadap PDRB, sehingga membutuhkan alternatif pengembangan ekonomi lainnya. Kondisi ini menuntut kualitas sumber daya manusia untuk memunculkan aktivitas olahan produk-produk bernilai dari potensi lokal Kabupaten Pringsewu. Kemunculan usaha berbasis kreativitas saat ini telah bermunculan di Kabupaten Pringsewu, sehingga perlu untuk mengembangkan usaha yang berbasis ekonomi kreatif. Pada artikel ini, dilakukan pemetaan klaster dengan pendekatan Analisis Hot Spot, terhadap seluruh pelaku usaha ekonomi kreatif. Analisis ini menunjukkan eksistensi jumlah dan persebaran para pelaku usaha ekonomi kreatif yang mengelompok di Kabupaten Pringsewu. Klaster ekonomi kreatif di Kabupaten Pringsewu dominan terbentuk di Kecamatan Pagelaran, Pagelaran Utara dan Gadingrejo. Klaster yang terbentuk pada penelitian ini berupa kluster sektor kriya, musik, fashion, makanan ringan dan sektor kreatif lainnya. Penelitian ini menunjukkan terdapat pengelompokan usaha ekonomi kreatif terjadi di Kecamatan Gadingrejo dan Pagelaran Utara yang merupakan kecamatan di luar ibukota Pringsewu. Keberadaan pelaku usaha ekonomi kreatif dapat menjadi alternatif penggerak roda ekonomi di kawasan diluar ibukota Pringsewu.
Pengarusutamaan Gender dalam Perspektif Strukturasi: Analisis Penyelenggaraan Organisasi PKK pada Pembangunan Desa
Authors: Susilowati Retno , Khairunnas Khairunnas , Rafinzar Rahmat , Tamsyah Indra
Published: July 2024

The involvement of women in several village development programs which is still very low when compared to the quantity of men's involvement in government and village development programs is the background of this research. The research was conducted in Pulau Semambu  Village, Ogan Ilir. The formulation of the research problem is how the role of the PKK organization in village development is viewed from a structuring perspective. The purpose of this research is to see the role of the PKK organization in village development. The method used is Descriptive Qualitative with data analysis techniques with Miles and Huberman's interactive model and data validation with triangulation. The results showed that the role of the Pulau Semambu  Village PKK organization had a positive impact on the development program, but not all of the main PKK programs had gone well. There are still obstacles in managing the PKK organization, especially human resources, infrastructure, and budget issues. The government needs to provide support to PKK managers at every level both materially and immaterially.
Public Service Quality dan Customer Satisfaction: Mengekplorasi Atribut Kualitas Pelayanan Pada Sektor Publik
Authors: Tri Nugraha Joko , Orbawati Eny Boedi , Fadlurrahman Fadlurrahman , Mukti Ari , Ikhtiara Seiren
Published: July 2024

The quality of public services is the most important thing to know whether they are successful in fulfilling services. The quality of service reflects the quality of the bureaucracy. The objectives of the study include identifying weaknesses or shortcomings of public service delivery and measuring the tendency of public satisfaction level with public services. Using a survey method with 100 respondents. The analysis technique uses a descriptive statistic. The results showed that there are 3 dimensions of service that need to be improved, including: (1) The dimension of fairness of costs / tariffs in services; (2) The dimension of conformity of service products between those listed in the service standard and the results provided and (3) Dimensions of quality of facilities and infrastructure.
Dampak Transformasi Digitalisasi terhadap Perubahan Perilaku Masyarakat Pedesaan
Authors: Sari Jayanti Armida , Diana Bambang Agus
Published: July 2024

The advancement of digitalization has significantly influenced the behaviors and culture of rural communities. This research aims to provide an in-depth insight into the complexity of the impact of digital transformation on the behaviors and culture of rural communities while highlighting the importance of addressing these challenges wisely and proactively. The research methodology employed in this study is descriptive qualitative with a literature review approach. Through literature analysis, this study explores various impacts of digitalization transformation on rural communities in Indonesia, including access to new information, economic opportunities, changes in behaviour regarding information access, communication, education, agriculture, healthcare, and economic empowerment. Findings indicate that digitalization has opened access to information and new economic opportunities for rural communities, mainly through the widespread penetration of the Internet and the adoption of digital technologies. Furthermore, changes in the behavior of rural communities occur across various aspects of life, including communication, education, healthcare, and agriculture. Despite the benefits of digitalization, efforts must mitigate adverse impacts such as online fraud and the spread of false information. Therefore, inclusive, and sustainable strategies for digital village development and increasing digital literacy are crucial in maximizing the benefits of rural digitalization in the future.
Radiation exposure in patients during COVID-19 pandemic
Authors: Feitosa Chaves Thailane Marie , De Acioly Rodrigues Mariana Luiza , Cavalcanti de Albuquerque Emídio , Martins de Lima Maria Carolina
Published: July 2024

IntroductionDespite advances in knowledge about COVID-19, it remains a multifaceted disease, with several aspects still requiring further investigation. There is an ongoing need to access and understand long-term, lasting effects of COVID-19 or its clinical handling. The main objective is to analyze risks associated with the radiological investigation performed in patients with neurological symptoms and COVID-19 during the initial pandemic.MethodsA group of 116 patients, referred to a Neurological-Unit during the initial semestre (Apr-Sep/2020) of the pandemic in Pernambuco, Brazil, and positivity (SARS-CoV-2 RT-PCR) for COVID-19 was compared to a similar group, conducted under the same institutional protocols, in a pre-pandemic period. All investigation data used are part of Institutional-Clinical-Image-Databank (BIC-HPS), which automatically stores all imaging performed at the Unit. Groups were similar (in age, p=0.73; sex, p=0.78; and main comorbidities at admission: hypertension p=0.30, diabetes-2, p=0.09).ResultsThe COVID-19-group was submitted to a significantly greater number of investigations (medical imaging: p<0.001, radiological exams: p<0.001, and number of tomographic scans: on average: 3.4, 1-12, ±2.0, p<0.001), surpassing safety-limits for radiation exposure.ConclusionsThe study points out the elevated number of clinical investigations undertaken in COVID-19 patients during early pandemic and highlights risks associated – including long-term health risks associated with radiation exposure.
Chamberlain’s line, clivus-canal angle, Welcker’s basal angle, Boogaard’s angle, and foramen magnum angle: a brief review for type B basilar invagination
Authors: Nascimento José Jailson C do , Silva Leandro M , Diniz Paula R. B. , Araújo-Neto Severino A.
Published: July 2024

IntroductionType B basilar invagination (BI) is an abnormality of the craniovertebral junction (CVJ).  Since first descriptions occurred in the 18th and 19th centuries BI have gained remarkable clinical and surgical importance.ObjectiveTo describe usual craniometric parameters of assessment of type B BI and to discuss future perspectives of craniometry in the field.MethodsThis is a brief review of the literature on the CVJ parameters used for the BI diagnosis. ResultsAlthough there are several craniometric parameters used in the diagnosis of BI, there are few studies on the validation of these parameters on radiography and volumetric images.  Accuracy studies for Chamberlain’ line, clivus-canal angle, Boogaard’s angle, Welcker’s basal angle, and foramen magnum angle occurred consistently at CT and MRI. Brachycephaly and reduced cranial height are strongly associated with type B BI.ConclusionThe classical parameters of the Chamberlain's line, Boogaard's angle and clivus-canal angle are still important tests for the diagnostic evaluation of type B BI.
360 years of Cerebri Anatome
Authors: Martins Antonio Cavalcanti de Albuquerque , Martins Carolina , Valenca Marcelo Moraes
Published: July 2024

Article Type Image
Pengaruh Kualitas Pelayanan, Harga Tiket, Fasilitas dan Citra Destinasi terhadap Keputusan Berkunjung pada Kolam Renang Pandanaran Hills
Authors: Ananda Fariz , Safitriani Ayu , Firdaus  , Astono Ari Dwi , Septiana Zulfa , Puspitasari Irma
Published: July 2024

The purpose of this research is to determine the influence of service quality, ticket prices, facilities, and destination image on the decision to visit the Pandanaran Hills swimming pool. The population in this study is unknown or cannot be determined, while the sample is 100 respondents. The method used in this research is a quantitative method involving visitors to the Pandanaran Hills Swimming Pool. The data collection technique in this research is nonprobability sampling with the accidental sampling method. The data analysis technique used in this research is Ordinal Logistic Regression using SPSS software. The research results show that based on the results of the w test, service quality has a positive and significant effect on visiting decisions with value and with significant value. Ticket prices have a positive and significant effect on visiting decisions. Facilities have a positive and significant influence on the decision to visit. Destination image has a positive and significant influence on the decision to visit. Simultaneously, Service Quality, Ticket Prices, Facilities and Destination Image have a positive and significant influence on the decision to visit visitors to the Pandanaran Hills Swimming Pool.
Keywords: service quality, ticket prices, facilities, destination image, visiting decision
Analisis Pemasaran Kambing Saburai di Desa Gisting Atas Kecamatan Gisting Kabupaten Tanggamus
Authors: Tina Suhartina , Herdiansah Riko
Published: July 2024

Livestock farming is one of the agricultural sectors that has an important role in supporting people's need for consumption of animal protein. Animal husbandry is not only directed at increasing production but is expanded into processing and marketing (Agribusiness). Goats are one of the small ruminant livestock that has great potential to be developed in Indonesia, especially in Gisting District because it has enormous potential to be developed in Indonesia, apart from providing animal protein needs, but also as a way to improve the community's economy. Goats are small ruminants that are relatively easy to maintain and can eat a variety of forages, especially young leaves. Goats also adapt very quickly to the place where they are kept so that goats can also live in rocky areas, forests and mountains. BPS 2018, the goat population in Indonesia reached 18,720,706 heads, 53.76% of which were found on the island of Java and the rest were spread outside Java, including in Lampung Province. Lampung Province is the province with the highest goat population compared to other regions outside Java. The population reached 1,297,872 individuals. The population of Saburai goats alone in 2018 reached 3000 heads. Marketing is a process and managerial process that enables individuals or groups to get what they need by creating, offering and exchanging products of value to other parties or all activities related to the delivery of products or services from producers to consumers. Research Objectives: To determine the characteristics of marketing institutions involved in marketing Saburai goats, to understand marketing functions, to understand marketing efficiency analysis and price determination at Saburai goat farmers in Gisting District. The method used in this research is a survey method with respondents who are marketing goats. saburai are breeders and buyers. Surveys are a method of collecting primary data by asking individual respondents questions in the form of a questionnaire.
Keywords: marketing, saburai goat
Pengaruh Kualitas Layanan dan Tingkat Harga terhadap Loyalitas Pelanggan
Authors: Kurniawan Muhammad Agung Wahyu , Novian Mochamad Hangga
Published: July 2024

This study aims to determine and explain the effect of service quality and price level on customer loyalty at AHASS 7662 Simongan Jaya Semarang. The research was conducted by distributing questionnaires via googleform to 100 respondents and processed with the help of IBM SPSS version 26. The results showed that: (1) There is a positive and significant effect of service quality on customer loyalty with the value of tcount> ttable, namely 5.799> 1.984, (2) There is a positive and significant effect of price level on customer loyalty, the value of tcount> ttable, namely 10.124> 1.984, (3) There is a positive and significant effect of service quality and price level simultaneously on customer loyalty with the value of Fcount> Ftabel, namely 10.124> 3.09. Suggestions in this study are (1) Service providers are expected to complete the availability of motorbike or spearpat products so that customers can easily reach the services needed, (2) Service providers are expected to review and consider the price level given to customers with competitor price levels for similar services.
Keywords: service quality, price level, customer loyalty
Pengaruh Orientasi Kewirausahaan dan Daya Saing terhadap Kinerja Bisnis
Authors: Rinova Dora , Gunevi Adetya Putra , Oktaviannur M.
Published: July 2024

In the competitive landscape of the snack industry, every business player is required to possess a strong entrepreneurial orientation to achieve the desired goals. Entrepreneurial orientation in the context of snack sales involves the ability to create new and different things. This includes creative thinking and innovative action to generate new opportunities. Thus, this effort encourages individuals to have enthusiasm, a proactive attitude, adaptive behavior, and the necessary skills to manage a business or activity focused on the exploration, creation, and implementation of new ways of working, technologies, and products. Data collection was carried out directly using questionnaires and interviews with employees at UD Sanjaya. The analysis used to determine the influence of independent variables on dependent variables is quantitative statistical analysis. The results of the study are as follows: Entrepreneurial orientation (X1) partially influences business performance, Competitiveness (X2) partially influences business performance (Y), and Entrepreneurial orientation (X1) and competitiveness (X2) simultaneously influence business performance (Y).
Keywords: entrepreneurial orientation, competitiveness, business performance
Analisis Jasa Rekening Bersama dalam Keamanan Transaksi Grup Facebook Mobile Legends Ngab-Ngab
Authors: Fahlevi Diega Chandra , Amir Aprilianto , Suradi
Published: July 2024

Technological advances allow transactions to be carried out online even though the distance between buyers and sellers is very far, it can also be through used knowed e-commerce to avoid fraud. If the transaction is carried out outside knowed e-commerce will be prone to fraud such as the seller fleeing shortly after the buyer sends money or vice versa the buyer who runs away after the seller sends the goods. With the rise of such fraud cases comes an online service called joint account services. Joint account services are services that bring up third parties who are certainly neutral between buyers and sellers to help secure a transaction. The purpose of this study is to find out how joint account services can improve transaction security. The benefits of this research are expected to help prospective buyers and sellers avoid fraud and introducing joint account services more widely to the public. This research was conducted in one of the Facebook groups called Mobile Legends Ngab-Ngab where online transaction activities which are prone to fraud were frequent. Using qualitative descriptive research methods researchers conduct observations and interviews with informants to find out whether using joint account services can help secure transactions. After conducting observations and interviews with informants, researchers concluded that using joint account services when transactions can increase the security of an online transaction especially by doing Reff status which will be a kind of warranty for buyers.
Keywords: joint account, online transaction security, reff, services
Evolusi Public Relation Di Era Digital
Authors: Septiyani Dwi Ayu
Published: July 2024

Pesatnya kemajuan teknologi saat ini berpengaruh terhadap fungsi Public Relation suatu perusahaan atau organisasi, dimana teknologi ini dapat membantu organisasi berkomunikasi dengan public mereka terutama pada tahapan transformasi digital. Hal ini tentunya melahirkan peran dan fungsi PR untuk semakin maksimal dengan penggunaan teknologi baru. Metode penulisan yang digunakan yakni menggunakan studi kepustakaan atau literatur yang bersumber dari jurnal, e-book mengenai Public Relation. Hasil kajian menunjukkan bahwa kemajuan teknologi, khususnya teknologi digital saat ini memengaruhi konsep dan kinerja bagian PR pada setiap organisasi. Kinerja Public Relation kini tidak dapat dipisahkan lagi dari internet. Internet tidak hanya menjadi instrumen fisik dalam mengelola suatu perusahaan atau organisasi tetapi juga menjadi medium untuk mengelola hubungan organisasi dengan public. Beberapa fasilitas internet yang telah digunakam PR di era digital sekarang antara lain: situs web (web site); e-mail (electronic mail); mailing list (milis), media social (social media); aplikasi chatting (komunikasi langsung); dan bisa juga aplikasi sistem Informasi Manajemen (SIM).
Pengaruh Komunikasi Interpersonal Tourguide Terhadap Kepuasan Pengunjung di Taman Mini Indonesia Indah
Authors: Sulistyo Dandi , Putriana Muria , Imsa Mentari Anugrah , Sari Wina Puspita
Published: July 2024

Penelitian ini bertujuan untuk mengevaluasi dampak komunikasi interpersonal tourguide pada kepuasan pengunjung di Taman Mini Indonesia Indah serta mengamati partisipasi pengunjung dalam interaksi mereka dengan tourguide. Hipotesis penelitian ini menyatakan bahwa ada keterkaitan yang signifikan antara komunikasi interpersonal tourguide dengan tingkat kepuasan pengunjung di Taman Mini Indonesia Indah. Metode penelitian yang digunakan adalah kuantitatif deskriptif. Populasi penelitian ini mencapai 267.952 ribu dan sampel yang diambil berjumlah 100 responden, dihitung menggunakan rumus slovin. Accidental sampling  adalah teknik pengambilan sampel yang dipilih adalah. Hasil penelitian memperlihatkan nilai uji korelasi Pearson sebesar 0,770 dengan tingkat signifikansi 0,001. Hasil ini menegaskan bahwa komunikasi interpersonal tourguide berhubungan positif dengan kepuasan pengunjung di Taman Mini Indonesia Indah. Dari analisis regresi linear sederhana, ditemukan bahwa nilai signifikansi adalah 0,001, sehingga hipotesis Ha dapat diterima, yang menyatakan bahwa terdapat hubungan yang positif dan signifikan antara komunikasi interpersonal tourguide dengan tingkat kepuasan pengunjung. Berdasarkan temuan ini, semakin efektif komunikasi interpersonal yang dilakukan oleh tourguide, semakin tinggi tingkat kepuasan pengunjung di Taman Mini Indonesia Indah, semakin besar kemungkinan pengunjung untuk merasa puas dengan kunjungan mereka.
Pemberdayaan Kader Kesehatan dalam Meningkatkan Kualitas Hidup Lansia dengan Inkontinensia Urine
Authors: Rustiana Kusumawati Yoni , Utomo Budi , Setiawan Setiawan
Published: July 2024

Latar Belakang : Penuaan yang terjadi pada lansia menyebabkan menurunnya kekuatan otot dasar panggul yang menyebabkan lansia tidak mampu mengontrol aktivitas buang air kecilnya sehingga menyebabkan lansia menderita inkontinensia urin. Latihan untuk mengatasi inkontinensia urin antara lain latihan otot dasar panggul yang disebut Kegel exercise. Kegel exercise merupakan suatu latihan otot dasar panggul dengan cara mengontraksikan dan mengendurkan otot-otot dasar panggul untuk memperbaiki kondisi akibat penurunan fungsi otot dan memperkuat otot-otot dasar panggul. Metode : Penyuluhan tentang kualitas hidup lansia penderita inkontinensia urin. (2) Pelatihan dan praktek senam kegel bagi kader kesehatan (3) Pelayanan dengan pemberdayaan kader masyarakat untuk meningkatkan kualitas hidup lansia penderita inkontinensia urin.Hasil : Terdapat peningkatan pemahaman dan keterampilan kader kesehatan dalam meningkatkan kualitas hidup lansia penderita inkontinensia urin, dan meningkatnya kualitas kesehatan masyarakat.Kesimpulan: inkontinensia urin dengan latihan kegel exercise terbukti meningkatkan kekuatan otot dasar panggul dan menurunkan angka kejadian inkontinensia urin pada lansia. Kualitas hidup lansia meningkat dan frekuensi buang air kecil harian menurun setelah senam kegel diberikan secara rutin. Kegiatan edukasi kesehatan dan senam kegel harus dilakukan secara rutin agar dapat memberikan manfaat kesehatan dan preventif bagi lansia, baik yang pernah maupun belum mengalami masalah inkontinensia urin
Social media applications in biomedical research
Authors: Hussain Md Sadique , Tewari Devesh
Published: July 2024

Information and communication technologies (ICTs) have transformed global connectivity, offering significant support to underserved populations and small businesses in developing nations. The integration of social media into the ICT landscape has further revolutionized communication and information sharing worldwide. However, despite its widespread adoption, the precise impact of social media on biomedical research remains uncertain. This manuscript seeks to examine the multifaceted roles of social media in healthcare, focusing on its applications in patient care, professional networking, education, organizational promotion, and public health programs. Additionally, it investigates social media’s significance in research, particularly its potential for data collection and analysis. A comprehensive literature review was undertaken to consolidate existing knowledge on social media’s utilization in healthcare and research. Various platforms, including social networking sites and academic networking sites, were assessed, along with their respective applications and consequences. Social media platforms have become essential tools in healthcare, facilitating professional networking, patient education, organizational promotion, and public health initiatives. In the realm of research, social media provides extensive opportunities for data collection, analysis, and collaboration, although challenges persist regarding privacy, data accuracy, and ethical considerations. The pervasive influence of social media in healthcare and research highlights its potential to enhance communication, engagement, and knowledge dissemination. However, careful adherence to ethical guidelines and privacy concerns is essential to maximize its benefits while minimizing risks. As social media continues to evolve, its role in shaping biomedical research and healthcare practices is anticipated to grow, necessitating ongoing exploration and adaptation by stakeholders.
Influence of dental implant site preparation method on three aspects of the site: magnetodynamic mallet versus conventional drill
Authors: Baldi Domenico , Jones Jason Motta , Lertora Enrico , Burgio Chiara , Lugas Andrea Tancredi , Schierano Gianmario , Colombo Jacopo
Published: July 2024

Aim: Magnetodynamic surgery has assumed increasing importance in recent years. The purpose of the present study was to compare in vitro, using dry porcine ribs, two methods of dental implant site preparation (conventional drill and magnetic mallet) on three aspects of the site. These were the difference between the diameter of the site and the diameter of the last drill used (an index of the accuracy of the preparation), the weight loss of the specimen on which the site was prepared (index of the bone loss in the site), and the change of temperature at the site (an index of the change to the material at the site). Methods: Eight preformed pork ribs were chosen for the study. Four implant preparations were made on each rib, two with Magnetic Mallet (Meta Ergonomica, Turbigo, Italy) and two with traditional drills. Each bone sample was weighed before and after implant site preparation in order to calculate the amount of bone lost during preparation. The diameter of preparations was analyzed with the aid of an optical microscope (MZ6, Leica, Wetzlar, Germany) connected to a dedicated measurement software. For the evaluation of the temperature, eight preparation sites were marked. In correspondence of each preparation site, on the opposite side of the rib, a hole was made for the thermocouple (HI 91530K, Hanna Instruments, Padova, Italy). During the preparations, the thermocouple was kept inserted inside the control hole to record the temperature variation. The results were analyzed using appropriate statistical methods, such as the Kolmogorov-Smirnoff test and the Wilcoxon test. Results: It was found that mallet drill provided significantly higher accuracy of preparation, lower amount of damage at the site, and less change to the porcine rib test material at the preparation site. Conclusions: A possible clinical implication of this finding is discussed.
Perancangan aplikasi ensiklopedia games PC rekomendasi dengan metode SAW berbasis mobile android
Authors: Adnan Renaldi Fauzi , Ikrimach
Published: July 2024

Di era modern saat ini, memiliki akses ke informasi yang akurat dan komprehensif sangat penting, terutama bagi gamer yang ingin meningkatkan pengalaman bermain mereka. Proses manual ini sering kali membingungkan dan berpotensi menyebabkan kesalahan, terutama bagi pengguna yang kurang familiar dengan teknologi (gaptek). Dengan aplikasi mobile yang dirancang, pengguna hanya perlu menginputkan spesifikasi PC mereka dan memilih game yang ingin dicocokkan. Dengan ini memperkenalkan aplikasi seluler yang dirancang untuk bertindak sebagai ensiklopedia untuk gamer, menawarkan informasi rinci, akurat, dan cepat tentang berbagai permainan. Karena berbagai spesifikasi PC, tidak semua game berjalan dengan baik di setiap sistem. Aplikasi ini mengatasi masalah ini dengan merekomendasikan game yang dapat dimainkan dengan nyaman pada pengaturan PC tertentu pengguna. Mengingat biaya tinggi dari game asli, sangat penting bagi gamer untuk mengetahui terlebih dahulu apakah sebuah game kompatibel dengan PC mereka. Selain itu, aplikasi ini dikembangkan menggunakan bahasa pemrograman Kotlin dan menggunakan MySQL sebagai database, memastikan kinerja yang kuat dan manajemen data yang dapat diandalkan. Aplikasi ini menggunakan metode Simple Additive Weighting (SAW) untuk memberikan rekomendasi permainan yang cepat dan akurat berdasarkan spesifikasi PC individu. Dirancang untuk user-friendly dan menarik, aplikasi ini memastikan bahwa gamer dapat dengan mudah memahami dan menggunakan sistem matching PC-game untuk membuat keputusan yang tepat tentang pembelian game mereka. Untuk membuktikan efektivitas aplikasi ini, telah dilakukan penelitian yang menunjukkan bahwa aplikasi ini mampu memberikan rekomendasi yang akurat berdasarkan spesifikasi hardware PC pengguna. Hasil penelitian menunjukkan bahwa aplikasi ini dapat menampilkan rekomendasi dengan tingkat akurasi hingga 85%.
Rancang bangun aplikasi sistem booking pendaftaran berobat pasien poliklinik (simbolik) berbasis android menggunakan metode agile scrum
Authors: Iskandar  , Umar Tsani Abdurahman  , Djoko Nursanto  , Mohamad Anas Sobarnas
Published: July 2024

Pelayanan kesehatan merupakan salah satu kebutuhan primer yang sangat penting untuk kehidupan, karena kesehatan merupakan kebutuhan dasar hidup manusia, tetapi kenyataannya dalam mendapatkan kebutuhan tersebut tidak semua manusia mendapatkan pelayanan yang prima dan maksimal. Salah satu permasalahan timbul pada saat untuk mendapatkan suatu pelayanan kesehatan diantaranya pada saat melakukan pendaftaran pasien berobat pada fasilitas layanan berobat masyarakat seperti poliklinik kesehatan, permasalahan ditemukan pada waktu pasien melakukan antri dalam mengambil nomor pendaftaran secara langsung pada poliklinik yang dituju, pada kondisi ini sering terjadi masalah tidak mendapatkannya kuota berobat oleh pasien, dikarnakan adanya pembatasan jumlah kuota pada poli tertentu sehingga pasien yang sudah mengantri tidak bisa dilayani untuk berobat pada hari itu, hal ini menyebabkan pembuangan waktu yang sia-sia dan dapat menimbulkan kekecewaan pada pasien karena kurangnya informasi terakit jumlah kuota berobat pada poli tertentu terutama pada layanan-layanan yang menggunakan fasilitas tertentu. Penelitian ini bertujuan untuk merancang sebuah sistem aplikasi pendaftaran booking  pasien berobat pada poliklinik (Simbolik) berbasis android, dimana sistem yang dirancang nantinya pasien untuk berobat pada poliklinik untuk poli dan dokter tertentu bisa dilakukan dengan secara online sehingga bisa dilakukan dari rumah dan cepat diketahui jumlah kuota untuk poli yang dituju, selain itu pasien dapat memilih memilih metode pembayaran yang dikehendaki seperti Asuransi, cash dan layanan yang lainnya. Rancangan antar muka aplikasi berbasis Android dengan sistem database MySql. Metode pengembangan perangkat lunak menggunakan Agile Scrum. Evaluasi pengujian perangkat lunak menggunakan ISO 9126 dengan emperoleh hasil nilai Usability: 76%, Functionality: 83%  dan Portability sebesar 75%. Hasil implementasi dan pengujian aplikasi menunjukan performance yang baik sehingga dapat digunakan dalam sistem pendaftaran pasien pada poliklinik secara online sehingga dapat menyelesaikan masalah pada pendaftaran pada poliklinik tersebut.
Tumor-Infiltrating Lymphocytes as a Target for Immunotherapy in Breast Cancer
Authors: Мнихович Максим Валерьевич , Борисов Денис Алексеевич , Тимофеев Роман Геннадиевич , Агафонова Юлия Сергеевна , Ерофеева Людмила Михайловна , Безуглова Татьяна Васильевна , Ширипенко Иван Александрович
Published: July 2024

В статье рассмотрены вопросы использования опухоль-инфильтрирующих лимфоцитов (TILs) в клинической практике, освещены новейшие исследования, посвященные поиску перспективных методов лечения онкологических больных на примере рака молочной железы (РМЖ) с разным уровнем лимфоцитарной инфильтрации. Одним из перспективных методов терапии опухолей в настоящее время является метод иммунотерапии, в основе которого лежит воздействие на иммунные контрольные «точки» или чекпоинты, представляющие собой систему ингибиторных механизмов, регулирующих активацию иммунного ответа. Клетки опухоли, воздействуя на чекпоинты, предотвращают активацию опухоль-специфических лимфоцитов и, таким образом, приобретают устойчивость к действию иммунной системы. Целью иммунотерапии является блокирование взаимодействия иммунных чекпоинтов и их лигандов, экспрессируемых клетками опухоли и её микроокружением, приводящее к реактивации противоопухолевого иммунного ответа. В связи с этим актуальными являются исследования, направленные на поиск молекулярных мишеней. Наиболее важным объектом этих исследований являются опухоль-инфильтрирующие лимфоциты. Для подготовки обзора проведен поиск литературы по базам данных Scopus, Web of Science, Medline, PubMed, CyberLeninka, РИНЦ и CNKI. При анализе использованы источники, индексируемые в базах данных Scopus, Web of Science, PubMed; 70 % работ опубликовано за последние 5 лет. Использовано 40 источников для написания данного литературного обзора.
Mechanisms of Formation of Specific Antitumor Immunity and Resistance to Immune Checkpoint Inhibitors
Authors: Султанбаев Александр Валерьевич , Тузанкина Ирина Александровна , Насретдинов Айнур Фанутович , Султанбаева Надежда Ивановна , Мусин Шамиль Исмагилович , Меньшиков Константин Викторович , Султанбаев Михаил Валерьевич , Сатышев Олег Викторович , Измайлов Адель Альбертович , Кудлай Дмитрий Анатольевич , Имянитов Евгений Наумович
Published: July 2024

Данный обзор посвящен механизмам работы противоопухолевого иммунитета и особенностям его формирования. Ингибиторы контрольных точек иммунного ответа изменили парадигму лечения больных со злокачественными новообразованиями (ЗНО). Иммунотерапия при многих ЗНО показала превосходящую стандартные химиотерапевтические опции эффективность. В данной работе представлен обзор литературных данных о механизмах формирования специфического противоопухолевого иммунитета и резистентности ЗНО к препаратам контроля иммунных точек. Для определения эффективности применения ингибиторов контрольных точек в клинической практике широко распространены маркеры: PD-L1 статус и микросателлитная нестабильность. Результаты исследований показывают, что уровень экспрессии PD-L1 определяет эффективность иммунотерапии. Наличие высокой микросателлитной нестабильности определяет чувствительность к терапии ИКТ независимо от гистологического подтипа. Наличие статусов PD-L1 и MSI является показанием для назначения блокаторов PD1 и PD-L1. Даже при наличии MSI и высокой экспрессии PD-L1 у определенной группы пациентов отсутствует эффект от проводимой терапии, что указывает о резистентности и отсутствии специфического противоопухолевого иммунитета. V(D)J-рекомбинации ДНК обеспечивают продукцию разнообразных антигенных рецепторов в развивающихся Т- и В-лимфоцитах, что представляется ключевым фактором развития специфического противоопухолевого иммунитета. Для определения эффективности иммунотерапии следует рассмотреть количественные показатели TREC и KREC.
The Use of Botulinum Toxin Type A for the Treatment of Animation Deformity after Simultaneous Breast Reconstruction
Authors: Далгатова Патимат Омардибировна , Зикиряходжаев Азиз Дилшодович , Грушина Татьяна Ивановна , Мошурова Марианна Валентиновна , Найдина Карина Александровна , Тимошкин Владислав Олегович
Published: July 2024

Рак молочной железы (РМЖ) продолжает занимать лидирующие позиции среди злокачественных опухолей у женщин. В современной реконструктивно-пластической хирургии выполнение одномоментных реконструктивных вмешательств с использованием эндопротезов составляет порядка 70-75 % всех реконструкций. При субпекторальной реконструкции частота встречаемости анимационной деформации достигает 76 %. При этом женщины испытывают дискомфорт в повседневной жизни, явления хронической послеоперационой боли. Варианты коррекции анимационной деформации, как правило, предполагают повторные хирургические вмешательства, что тем не менее не гарантирует надёжную коррекцию анимационной деформации, и лишь замена имплантата с установкой нового в препекторальную позицию, что не всегда возможно, радикально решает проблему. Целью настоящего обзора явилось обобщение функциональных и эстетических результатов инъекций ботулотоксина типа А (БТА) в область реконструированной железы, анализ методики, безопасности введения при лечении анимационной деформации. Проведённый обзор литературы показал, что применение ботулотоксина типа А является малоинвазивной, эффективной, однако обратимой альтернативой вариантам хирургического лечения. В подавляющем большинстве случаев введение осуществляли в большую грудную мышцу (в т. ч. интрооперационно) или в широчайшую мышцу спины, чаще в количестве 100 ЕД на одну зону, при этом показана безопасность повышения дозировки вплоть до 250 ЕД. Сообщений о возникновении локальных или системных неблагоприятных реакций выявлено не было. В связи с обратимостью действия рекомендовано выполнять повторные инъекции с интервалом в 3-4 месяца. Субъективный миорелаксирующий эффект наступал не раньше, чем через 3 суток после первой инъекции БТА и совпадал с появлением ощущений облегчения боли. Кроме того, применение БТА статистически значимо снижало потребление наркотических анальгетиков, начиная с 7-14 дня послеоперационного периода. В связи с ограниченным количеством исследований по затронутой тематике требуется дальнейшее наблюдение и изучение рассматриваемых в обзоре вопросов.
Cervical Cancer: A Comparative Study of Incidence, Mortality and Survival in the Northwestern Federal District of the Russian Federation and the Countries of Northern Europe
Authors: Мерабишвили Вахтанг Михайлович , Бахидзе Елена Вилльевна , Урманчеева Адилия Феттеховна , Берлев Игорь Викторович
Published: July 2024

Введение. Исследования заболеваемости, смертности и выживаемости являются важными показателями успеха борьбы с раком. В зависимости от географического положения, экономического состояния и уровня оказания медицинской помощи показатели заболеваемости, смертности и выживаемости онкогинекологических больных в различных регионах мира существенно отличаются.
Цель. Сравнительный анализ динамики заболеваемости, смертности и выживаемости больных раком шейки матки (РШМ) в Северо-Западном федеральном округе Российской Федерации (СЗФО РФ), в целом в Российской Федерации и в странах Северной Европы, располагающихся на тех же географических широтах за 10-летний период (2010-2020).
Материалы и методы. Показатели заболеваемости, смертности и выживаемости за период с 2010 по 2020 гг. по вновь созданной базе данных популяционного ракового регистра (БД ПРР) СЗФО РФ, в который входят 11 субъектов РФ. Показатели заболеваемости, смертности и выживаемости сравнивались с аналогичными в странах Северной Европы, данные которых получены с веб-сайта Association of the Nordic Cancer Registries https://nordcan.iarc.fr/en.
Результаты. Наблюдается сохранение стабильного уровня заболеваемости РШМ в целом по России и в Северной Европе и некоторое ее снижении в СЗФО с 2010 по 2020 гг., но уровень заболеваемости в России и СЗФО сравнительно выше, чем в Северной Европе. Самые высокие показатели заболеваемости РШМ в регионах СЗФО отмечены в Архангельской, Калининградской, Новгородской и Псковской областях. Самые высокие показатели заболеваемости РШМ в странах Северной Европы зафиксированы на Фарерских островах, в Гренландии и Норвегии, самые низкие — в Финляндии. Наблюдается снижение смертности женщин от РШМ в России, в СЗФО и в странах Северной Европы, но сохраняется разрыв между европейскими и российскими показателями. Одновременно в странах Северной Европы наблюдается тенденция повышения относительной выживаемости больных РШМ к 2017-2021 гг., тогда как в регионах СЗФО показатели выживаемости остаются без тенденции к повышению.
Заключение. Необходимо повышение эффективности диагностики и лечения РШМ в регионах СЗФО РФ.