bluuebunny/crossref_metadata_2025 huggingface dataset:
Computing Task Offloading in Vehicular Edge Network via Deep
Reinforcement Learning
Authors: He Beibei , Su Shengchao , Wang Yiwang
Published: February 2024

Background:

In recent years, with the development of the Internet of Vehicles, a variety
of novel in-vehicle application devices have surfaced, exhibiting increasingly stringent requirements
for time delay. Vehicular edge networks (VEN) can fully use network edge devices, such as roadside
units (RSUs), for collaborative processing, which can effectively reduce latency.

Objective:

Most extant studies, including patents, assume that RSU has sufficient computing resources
to provide unlimited services. But in fact, its computing resources will be limited with the
increase in processing tasks, which will restrict the delay-sensitive vehicular applications. To solve
this problem, a vehicle-to-vehicle computing task offloading method based on deep reinforcement
learning is proposed in this paper, which fully considers the remaining available computational resources
of neighboring vehicles to minimize the total task processing latency and enhance the offloading
success rate.

Methods:

In the multi-service vehicle scenario, the analytic hierarchy process (AHP) was first used
to prioritize the computing tasks of user vehicles. Next, an improved sequence-to-sequence
(Seq2Seq) computing task scheduling model combined with an attention mechanism was designed,
and the model was trained by an actor-critic (AC) reinforcement learning algorithm with the optimization
goal of reducing the processing delay of computing tasks and improving the success rate of
offloading. A task offloading strategy optimization model based on AHP-AC was obtained on this
basis.

Results:

The average latency and execution success rate are used as performance metrics to compare
the proposed method with three other task offloading methods: only-local processing, greedy strategy-
based algorithm, and random algorithm. In addition, experimental validation in terms of CPU
frequency and the number of SVs is carried out to demonstrate the excellent generalization ability of
the proposed method.

Conclusion:

The simulation results reveal that the proposed method outperforms other methods in
reducing the processing delay of tasks and improving the success rate of task offloading, which
solves the problem of limited execution of delay-sensitive tasks caused by insufficient computational
resources.
An Overview of Diverse Biological Activities of Cinnoline Scaffold
Authors: Asif Mohammad , Almehmadi Mazen M. , Alsaiari Ahad Amer , Aljuaid Abdulelah , Allahyani Mamdouh , Alsharif Abdulaziz
Published: February 2024

The cinnoline nucleus is a bicyclic ring and is an isosteric precursor to quinolone or isoquinoline.
Cinnoline analogs are aromatic heterocyclic compounds having diverse therapeutic activities,
such as antimicrobial, analgesic, anti-inflammatory, anti-tuberculosis, antimalarial, anticonvulsant,
antioxidant, anticancer, antihypertensive, anti-anxiety, and other activities. This heterocyclic
nucleus is attracting a lot of attention in medicinal chemistry and is used as a structural
subunit in various compounds with attractive medicinal and chemical properties. In this review, we
focus on the biological activities of cinnoline analogs with various substitutions.
Advances in Chemical Epigenetic Modification Methods in the Study of Fungal Secondary Metabolites
Authors: Liu Bing , Wang Yuxin , Chen Ning , Li Chenxue , Zhao Jintong , Li Ting
Published: February 2024

The secondary metabolites produced by fungi are an important resource for new drug
development, and the biosynthesis of fungal secondary metabolites is closely related to the epigenetic
status of the chromosomes in which their gene clusters are located. However, the induction
of fungal silencing of gene expression is one of the challenges faced at this stage. Chemical epigenetic
modification is a simple and effective method to regulate fungal metabolism by adding
chemical epigenetic modifiers to the culture medium to activate silent metabolic pathways in the
fungus, resulting in the production of cryptic natural products. This paper reviews the progress of
research on increasing the chemical diversity of fungal secondary metabolites using chemical epigenetic
modifications, with the aim of providing a reference for the in-depth study of fungal natural
products.
Detailed Analysis of the Anti-Inflammatory, Anti-oxidant, and Neuroprotective
Effects of the Potent Phytochemical Bacoside A
Authors: Wal Pranay , Verma Neha , Saxena Bhagawati , Singh Damini , Wal Ankita , Ved Akash , Rai Awani K , Sahani Vibhu
Published: February 2024

Bacoside A is a vital bioactive component of the Indian medicinal herb Bacopa monnieri,
which ranks second among the most significant medicinal plants. Bacoside A was discovered
to have more pharmacological activity than bacoside B. It has been used in Ayurvedic medicine to
treat mental problems and memory loss. It also possesses antioxidant, antidepressant, antiulcer,
hepatoprotective, ant-cancerous, vasodilator and other pharmacological properties. The main objective
of this review is to highlight the importance of Bacoside A in the treatment of various diseases.
Several sources were used to acquire the material, including review articles published in
various publications, such as PubMed, Scopus, Bentham Science, Elsevier, Springer Nature,
Wiley, and Research Gate, which were used to compile the data for the article following a thorough
analysis of the various research findings connected that had keywords, such as Bacoside A,
Ayurvedic medicine, Brahmi, jujubogenin. Bacoside-A, derived from the Bacopa monniera plant,
is a traditional medicine said to have therapeutic qualities. Various studies have found that bacoside-
A has considerable therapeutic benefits. All of the evidence suggests that Bacoside-A has
multiple therapeutic properties in regulating the various biological processes as well as paving the
path for the treatment of various disorders in modern medicine. The current review focused on the
pharmacological action of bacoside A. The results of the pharmacological investigations indicated
that Bacoside A had a wide range of pharmacological effects, including those on the central nervous
system (memory improvement), antioxidant, anti-inflammatory, antiparkinsonian, anticancer,
and more.
Extraction, Phytochemistry & Pharmacological Potential of Camellia
sinensis: A Comprehensive Review
Authors: Kaur Prabhjot , Gandhi Simran , Sharma Rubal , Kaur Lovepreet , Pal Mahak , Deswal Geeta , Chopra Bhawna , Grewal Ajmer Singh , Dhingra Ashwani K.
Published: February 2024

Camellia sinensis (L.) is acknowledged globally as the second most consumed beverage
after water. Researchers have dedicated substantial efforts to validate the claims surrounding this
plant through rigorous pharmacological screening, aiming to substantiate its traditional applications
in treating various ailments. This work extensively delves into aspects such as marketed formulations
of green tea, extraction techniques, phytochemistry, pharmacology, interactions between drugs and
green tea, and its distinctive characteristics. Key research unequivocally suggests that green tea holds
substantial health benefits for individuals. Presently, a multitude of pharmacologically active constituents
have been successfully isolated and identified from green tea, encompassing polyphenols, alkaloids,
amino acids, polysaccharides, and volatile components. Recent investigations have illuminated
the broad spectrum of pharmacological properties exhibited by green tea, encompassing antioxidant,
anticancer, hypoglycemic, antibacterial, antiviral, and neuroprotective attributes. The review amalgamates
current research findings to present a thorough understanding of the diverse bioactive compounds
found in Camellia sinensis, such as polyphenols, catechins, and alkaloids, and their contributions
to its health-promoting properties. The review further highlights the significance of extraction
techniques in preserving and enhancing the bioactivity of these compounds. Overall, this comprehensive
review serves as a valuable resource for researchers, practitioners, and enthusiasts, consolidating
the current knowledge surrounding Camellia sinensis and its multifaceted role in promoting human
health.
Artificial Intelligence-based Fair Allocation in NOMA Technique: A
Review
Authors: Kirtay Seda , Yildiz Kazim , Bocekci Veysel Gökhan
Published: February 2024

:

Non-Orthogonal Multiple Access (NOMA) is an innovation that has great potential in
wireless communication. It permits multiple users to efficiently allot a frequency band by adjusting
their power allocations. Nevertheless, attaining fair power allocation in NOMA structures presents
complex challenges that require specific models, extensive training data, and addressing issues of
generalization. This review aims to explore the applications of Artificial Intelligence (AI) and Deep
Learning (DL) methods to tackle the challenges associated with fair power allocation in NOMA
systems. The focus is on developing strong AI-DL models and creative optimization methods specifically
designed for dynamic environments to improve transparency and interpretability. This
study explores a wide range of techniques, including Reinforcement Learning, Convolutional Neural
Networks (CNN) for power allocation, Generative Adversarial Networks, Deep Reinforcement
Learning, and Transfer Learning. The goal is to enhance various aspects, such as power allocation,
user coupling, scheduling strategies, interference cancellation, user mobility, security, and deeplearning-
based NOMA. Despite the difficulties, impartial power allocation algorithms based on AI
and DL show promise in improving user performance and promoting fair power distribution in
NOMA systems. This study emphasizes the significance of continuous research efforts to overcome
current obstacles, enhance efficiency, and strengthen the dependability of wireless communication
systems. This highlights the significance of NOMA as an advanced innovation for upcoming wireless
generations that go beyond 5G. Future areas of study involve investigating federated learning
and novel techniques for gathering data and utilizing interpretable AI-DL models to address existing
constraints. Overall, this review highlights the potential of AI and DL techniques in achieving
fair power distribution in NOMA systems. However, further investigation is crucial to addressing
obstacles and fully exploring the capabilities of NOMA technology.
A Systematic Review on the Application of Power Eelectronics in Renewable Energy Systems using SWOT Analysis
Authors: Mumtaz Naiyer , Ahmed Md. Irfan , Pandey Harsh Wardhan
Published: February 2024

Background:

The frequency of energy crises due to shortage of fuel or rise in fuel prices
has increased in the past decade. This may be due to increasing energy demand, the financially
crippled state of the distribution companies, high prices of fuel, shortage of fuel, tension between
the countries, etc. Apart from this, climate change, global warming, and rising environmental concerns
have necessitated the need to search for more sustainable alternative sources of electricity. It
has created a lot of interest in Renewable Energy Sources (RES), which includes solar, wind and
hydropower. Even governments all around the world are introducing policies to support the adoption
of RES for the generation of electricity and have set the target to achieve the Net-Zero emission
level by decarbonizing the power sector.

Methods:

This paper provides an overview of all the prominent renewable energy technologies,
namely solar power plants, wind energy plants, biomass and hydropower, using a systematic review
procedure. In addition to this, the importance of Power Electronic Technologies (PET) in the
integration of RES in today’s power system has also been presented. Further, a SWOT analysis
framework has also been utilized to evaluate the strengths, weaknesses, opportunities and threats
associated with the application of PET in renewable energy systems.

Results:

The results from the analysis showcases that the implement of PET offers significant
strength for the implementation of RES in the power system by providing increased system efficiency,
and improved power quality. However, the technologies also face some of the weakness of
limited scalability, regulatory concerns, high initial cost etc. Further, the different opportunities
for a widespread adoption of PET have been discussed in this paper. Finally, all the threats concerning
the implementation of the PET in the RES in the modern power system have also been
highlighted.

Conclusion:

The purpose of this research work is to classify recent research techniques on renewable
energy sources that were published between the years of 2010 to 2022 through a systematic
and statistical review framework to showcase the need for power electronic technologies for the
implementation of RES.
Cynara Cardunculus Flavonoids-rich Fraction Alleviates Liver Injury in
Mice Overconsumed Fructose Model
Authors: Baali Nacera , Belloum Zahia , Benayache Fadila , Benayache Samir
Published: February 2024

Background:

Non-alcoholic Fatty liver disease (NAFLD) is becoming a major global
health burden in the world. Cynara cardunculus is an edible plant growing wild in the North of
Algeria. Its potential as a source of health-promoting compounds is still underexplored.

Objectives:

This study aimed to explore the preventive effect of Cynara cardunculus
(C.cardunculus) on the NAFLD model.

Methods:

Total flavonoid contents (TFC) and in vitro antioxidant effects of butanolic (n-
BuTOH) and ethyl acetate (EtOAc) fractions on scavenging the ABTS+ radical, inhibition of lipid
peroxidation and reducing power proprieties were assessed. The n-ButOH fraction showed
the highest TFC and antioxidant capacity in all realized assays. This fraction is used for anti-
NAFLD experiments. Adult male Albinos mice were divided into four groups. Group 1 was
normal control. Group 2 was watered with 30% of fructose for three weeks to induce the
NAFLD model. Group 3 and Group 4 were co-treated with C. cardunculus n-ButOH fractions
and Atorvastatin, respectively for three weeks. Blood and livers were collected for biochemical
and histological analysis.

Results:

The C. cardunculus n-ButOH fractions significantly restored levels of transaminases,
triglycerides, cholesterol, LDL, glucose and uric acid. The n-ButOH fraction exerted an improving
effect on the body and liver weight and liver index. It also significantly corrected the imbalance
in liver MDA and GSH levels. The n-ButOH fractions further ameliorated abnormalities in
liver histology through suppression of lipid droplet accumulation.

Conclusion:

This research proves that the flavonoid-rich fraction of C. cardunculus has protective
activity against high fructose intake in mice via reversing hyperlipidemia and boosting liver
antioxidant capacity.
Production, Optimization, and Characterization of Bio-cellulose Produced from Komagataeibacter (Acetobacter aceti MTCC 3347) Usage of Food Sources as Media
Authors: Ahmed Mazia , Saini Pinki , Iqbal Unaiza
Published: February 2024

Introduction:

Bio-cellulose is a type of cellulose that is produced by some particular
group of bacteria, for example, Komagataeibacter (previously known as Acetobacter), due to
their natural ability to synthesize exopolysaccharide as a byproduct. Gluconacetobacter xylinus
is mostly employed for the production of bio-cellulose throughout the world. Therefore, exploring
other commonly available strains, such as Komagataeibacter aceti (Acetobacter aceti), is
needed for cellulose production.

Methods:

Bio-cellulose is one of the most reliable biomaterials in the limelight because it is
highly pure, crystalline, and biocompatible. Hence, it is necessary to enhance the industrial manufacturing
of bio-cellulose with low costs. Different media such as fruit waste, milk whey, coconut
water, sugarcane juice, mannitol broth, and H&S (Hestrin and Schramm’s) broth were utilized
as a medium for culture growth. Other factors like temperature, pH, and time were also optimized
to achieve the highest yield of bio-cellulose. Moreover, after the synthesis of biocellulose,
its physicochemical and structural properties were evaluated.

Results:

The results depicted that the highest yield of bio-cellulose (45.735 mg/mL) was found at
30 °C, pH 5, and on the 7th day of incubation. Though every culture media experimented with synthesized
bio-cellulose, the maximum production (90.25 mg/mL) was reported in fruit waste media.
The results also indicated that bio-cellulose has high water-holding capacity and moisture content.
XRD results showed that bio-cellulose is highly crystalline in nature (54.825% crystallinity). SEM
micrograph demonstrated that bio-cellulose exhibited rod-shaped, highly porous fibers. The FTIR
results demonstrated characteristic and broad peaks for O-H at 3336.25 cm-1, which indicated
strong O-H bonding. The thermal tests, such as DSC and TGA, indicated that bio-cellulose is a
thermally stable material that can withstand temperatures even beyond 500 °C.

Conclusion:

The findings demonstrated that the peel of fruits could be utilized as a substrate for
synthesizing bio-cellulose by a rather cheap and easily available strain, Komagataeibacter
(Acetobacter aceti MTCC 3347). This alternative culture media reduces environmental pollution,
promotes economic advantages, and initiates research on sustainable science.
Electrospun Nanofibers for Transdermal Drug Delivery: Current Scenarios
Authors: Jiffrin Renatha , Abd. Razak Saiful Izwan
Published: February 2024

Electrospinning is a commonly used approach to fabricate nanofibers of
various morphologies. This method is highly effective and economically feasible,
capable of producing flexible and scalable nanofibers from a wide variety of raw
materials. To construct an ideal nanofiber with the desired morphological properties,
electrospinning parameters involving the process, solution, and ambiance need to be
fulfilled. Electrospun natural and synthetic polymeric nanofibers have recently proved
to be a promising technique for drug delivery systems. Nanofiber-based drug delivery
mechanisms can be utilised to transport drugs to specific locations and for a period of
time to obtain the intended therapeutic outcomes. The use of electrospun nanofibers as
drug carriers in biomedical applications, particularly in transdermal drug delivery
systems, may be impressive in the future. Generally, in this kind of system, the active
agent or drugs are delivered through the skin into the systemic circulation through a
transdermal drug delivery mechanism that is distributed through the skin’s surface.
Therefore, by using electrospun nanofibers as the carrier of drugs for transdermal
delivery, the system can enhance the drug’s bioavailability and achieve controlled
release.
Tissue Engineering Approach for Corneal Regeneration
Authors: Salih Mohamed , Shaharuddin Bakiah
Published: February 2024

There is an inadequate supply of tissues and organs for transplantation due to limitations in organ donors and challenges surrounding the use of autografts. The search for biodegradable and compatible tissue constructs as a platform for cellular, gene, and immune therapies, as well as drug deliveries, warrant intensive investigations. Biologically compatible materials with unique properties are needed as substrates or scaffolds for many types of cellular and gene therapies, which include treatment for ocular surface regeneration. Although the cornea is one of the most successful organ transplantations because it is considered an immune-privileged site, there are limitations like the risk of graft rejection, the transmission of diseases, and the scarcity of donors. Based on a clear understanding of the anatomy and physiology of the cornea, types of biomaterials, fabrication, and adjunct use of biologics are among the regenerative strategies employed in the tissue engineering approach for corneal regeneration. This chapter highlights the indications for cornea replacement, common biomaterials, and biologics used in this field.
A randomized controlled clinical study to evaluate the efficacy of Aragwadha Pushpa Lepa (Cassia fistula Linn.) in the management of Vyanga with special reference to Melasma
Authors: M Nanditha , C D Mahesh , Pradeep Seema
Published: February 2024

Vyanga is one of the Kshudraroga mentioned in the classics which are having Lakshana like Niruja, Tanu and Shyava Mandala. It can be correlated with Melasma in modern terms, which is also known as Chloasma. Melasma is an acquired pigmentary disorder, causing hyper-pigmented patches to appear on the facial skin. The prevalence varies between 1.5 % and 33.3 % in India. Female to male ratio in India is 4:1, indicating the high prevalence rate among females. Aragwadha Pushpa Churna along with Nimbuka Swarasa is applied over the hyper-pigmented patches in the condition of Vyanga in Cauvery river stretch of Namakkal district of Tamil Nadu as a folklore practice. A randomized clinical study was carried out to compare the efficacy with Varnya Gana Churna. The clinical study in the sample size of 30 was carried out in 2 groups with the intervention of Group A being Aragwadha Pushpa Churna Lepa and that of Group B being Varnya Gana Churna Lepa, with 30 days of drug application period and 15 days of drug-free follow up period. Differential diagnosis was ruled out with the help of Wood’s lamp. Assessment was done with the help of criterias like Amount of discolouration, Arbitrary grading and Area of the lesion. Various statistical tests like Parametric, Non-parametric, Friedman repeated measures ANOVA on ranks, etc. were carried out to analyse the results of the study. Both Aragwadha Pushpa Churna and Varnya Gana Churna have significant effect in the management of Vyanga with special reference to Melasma. When improvement in the individual criteria was compared, Aragwadha Pushpa Churna showed better results in reducing the amount of discolouration & the number of lesions. Whereas, Varnya Gana Churna showed better results in reducing area of the lesion.
A pharmaceutical standardization of Shunthi (Zingiber officinale): A Research Article
Authors: Ajay Kumar Singh  , Sanjiv Kumar  , Sampurna Nand Tiwari
Published: February 2024

Introduction: Shunthi (Zingiber officinale) is a dried form of Adaraka. Adaraka means Aadryati Jihva i.e., which keeps the Jihva moistened by increasing salivation in mouth whereas Shunthi dries up the water content of Kapha and checks its flow. Its rich history of use for centuries, is owing to its composite therapeutic properties. Aims and Objectives: The present study is aimed to standardization of Shunthi. Materials and Methods: Preparation of Shunthi Churna from its Kanda (Rhizome). This article focuses on the pharmaceutical preparation and standardization of Shunthi to ensure consistent quality and potency in herbal formulations. Standardization involves the quantification of key bioactive compounds such as alkaloids, carbohydrates, steroids, tannins and starch, which contribute to its therapeutic effects. For the identification, purity and strength these must be fulfilled - analytical parameters like loss on drying at 110°C, total ash value, acid insoluble ash, alcohol soluble extractive, water soluble extractive and moisture content in drug. Conclusion: Shunthi Churna is used for Grahani, Pandu, Shwasa Roga, Arsha, Amvata, Rajyakshma, Shula, Anaha etc. The rare side effects are increased bleeding tendency, rash, itching sensation and swelling of tongue, lips and throat. Drug interaction: Shunthi can interact with anti-inflammatory medications like Ibuprofen, Aspirin etc. and other drugs that affect bleeding tendency.[1] Contraindication: In Summer and autumn seasons, contraindications with Pittaja Vyadhi.[2] Hence the present work may be used for the quality assessment and standardization of Shunthi (Zingiber officinale).
A review article on types of Dhatu-Kshaya (depletion) and its clinical significance
Authors: Rupali  , Rupali Kapoor  , Sakshi Chauhan  , Rajesh Kumar Manglesh
Published: February 2024

Ayurveda is an old science that is very scientific and based on several fundamental principles. The science of life, or Ayurveda, categorizes the body's constituents within three essential elements Dosha (tissue entities), Dhatu (biological entities), and Mala, or waste materials. The balance between these entities is crucial to the durability and healthy lives for people. Similar to a progressive evolutionary metamorphosis, the production of Saptadhatus begins with the fundamental product of digestion, called Rasa Dhatu, and continues with the production of Rakta (blood tissue), Mamsa (muscle tissue), Meda (fat tissue), Asthi (bone tissue), Majja (bone marrow), and Sukra Dhatu (feces from reproduction). Every Dhatu is the basis for every other one and nourishes the one above it. The meals keep the steadily decreasing Dhatus in balance. That suggests the Dhatus are interdependent, with modifications to one causing modifications to the other. The goal of this review is to integrate different sources and arrive at a consensus. This paper explains the concept of Dhatu-Kshaya (depletion) in general terms and gives examples of how it can be used in real-world situations.
Conceptual study of Sira
Authors: Manisha Mahadev Kattikar  , Anju Thomas
Published: February 2024

Ayurveda is an ancient medical science which have proved for more than 5000 years ago. Dosha, Dhatu, and Mala are regarded as the fundamental elements of the human body. In addition to these components, Sira is a significant entity in which Rasadi Dhatus and Ojas flows from one place to other in the body. It is one among the Marma Vastu. In Ayurveda, the word Sira, Dhamani and Srotas are used interchangeably. All of these structures are present very closely and are minute and serves different functions in the body. Two chapters in Shareera Sthana in particular have been provided by Acharya Sushruta to explain the Sira.
A comprehensive guide to Andopanaha - A modified Swedana procedure that can be utilized in Panchakarma in various forms
Authors: Vipinsha R.S.  , Bibin K.B.  , Amritha Thilak
Published: February 2024

Introduction: The Upanaha Sweda and Anda Pinda Sweda have wide levels of application in Ayurveda practice. Upanaha Sweda is mentioned by Acharya Charaka in Niragni Sweda type. Whereas, other classics like Susruta Samhita and Astanga Hrudaya mention it in the Sagni Sweda variety. So, combining both the views of Acharyas, we can interpret that there are 2 types of Upanaha i.e., Sagni Upanaha & Niragni Upanaha. Anda Pinda Sweda is a type of Snigdha Sankara Sweda. These two classically mentioned therapies are less utilized in many institutions due to various reasons. Here in this study, we are trying the sort out the practical difficulties and find the possible modifications of these classical procedures for their utilization in the modern era. Methodology: With the main intention of developing a Snigdha Swedana procedure having both the benefits of Anda Pinda Sweda and Upanaha Sweda, the Andopanaha is designed. Here in this new method, the Dhanya Dravya is replaced by the (Kukkuta Anda) egg white, which is also a good binding agent. Observations: Compared to the Anda Pinda Sweda procedure the contact of Egg proteins with the skin is more in the Andopanaha procedure. Which helps is more analgesic effects and anti-inflammatory effects of the egg proteins. Discussion: The paper is prepared by authors with the intention that procedures and standards of care must be updated with modern tools and technologies without violating the basic principles of Ayurveda. If the old procedures need any changes according to the modern era they must be followed for their propagation in the public.
Effect of Panchkarma and Panchtikta Ghrita Guggulu in Katigraha w.s.r. of Lumbar Spondylosis - A Case Study
Authors: Shivani Paliwal  , Manisha Pandey  , Kamini Soni
Published: February 2024

Low back pain has become a major health problem now days, about 60-80% of world population experience lower back pain at some time in their lives. Katigraha is one among the Vata Nanatmaj Vyadhi described in Gadanigraha and Sharangadhar classical text. Acharya Shodhalya described that it is condition characterized by pain and restricted movement of Kati which can be correlated with the Lumbar Spondylosis. Lumbar Spondylosis is degenerative condition affecting the Disc, Vertebras, and associated Joints of Lumbar Spine. In Modern Science there are no effective treatments are available for this condition but in Ayurveda there is safe and effective regimen described by our Acharyas.  In our case study diagnosed case of Lumbar Spondylosis with the complaints of lower back pain, stiffness and difficulty in walking and standing, tingling sensation since 2 month. In our treatment regimen externally Kati Pizhichil, Shashtikshali Swedan, and internally Panchtikta Ghrita Guggulu, Panchtikta Ksheera Basti and Matra Basti with Ksheera Bala Tail were given. During this procedure different parameters are assessed before and after treatment there is significant relief in previous complaints.
Ayurvedic management of Plaque Psoriasis - A Case Study
Authors: Ajay Paul  , Neethu KS
Published: February 2024

Psoriasis is a chronic inflammatory disease affecting mainly in skin and joint. In Ayurveda, under the umbrella of Kushtha all skin diseases are described. In management of Psoriasis Ayurvedic system of medicine is giving good results. The main line of treatment of skin diseases in Ayurveda is repeated Samshodhana (purificatory therapies) along with Samshamana (palliative therapies). Three assessments were done before and after treatment on scoring of Dermatology Life Quality Index (DLQI), Psoriasis Disability Index (PDI) and PASI score. Score of the patient was 83% before treatment and 16% after treatment and 10% after follow up on Dermatology Life Quality Index (DLQI), 86% before treatment and 65% after treatment and 41% after follow up on Psoriasis Disability Index (PDI) and 35.5% before treatment, 10.2% after treatment and 8% after follow up in PASI (Psoriasis Area and Severity Index). This case study wants to substantiate the effectiveness of Ayurvedic treatment in the management of Plaque psoriasis.
Bilateral High Division of Brachial Artery: A Case Report and Clinical Significance in Ayurvedic and Modern Medical Practice
Authors: Muraleedhar Badiger  , Shivakumar Yaragal  , Rafiyabanu Talikoti
Published: February 2024

The brachial artery is a major artery of arm and continuation of the axillary artery. It begins at the lower border of the teres major muscle and ends at the level of the neck of the radius in deeper part of cubital fossa by dividing into radial and ulnar arteries. The brachial artery variations were observed in its course, branching pattern and division. Higher division of brachial artery is one of the common variations ranging from 15% to 20% of population. The course, termination and precise knowledge of variations of Brachial Artery is an important aspect in the clinical practice of Physician, Vascular surgeons, and Radiologist.
A randomized open labelled controlled clinical study to evaluate the role of Krutamalakadya Sutra in the management of Bhagandara with special reference to Fistula-In-Ano
Authors: Naveen Kumar J  , Muralidhara N  , KM Sweta
Published: February 2024

Acharya Sushruta has included Bhagandara as one among the Ashtamahagadas. Fistula in ano is an ano-rectal condition with a worldwide prevalence of 8.6 cases per 100,000 population. Ksharasutra ligation is one of the popular modalities in treatment of Bhagandara. In present era, there are different types of Ksharasutra available. Most widely used Ksharasutra is Apamarga Ksharasutra which is having Chedana, Bhedana, Lekhana properties and anti-inflammatory effect on the fistula tract. But some of the problems are faced during preparation and also in the course of Ksharasutra therapy viz, collection and preservation of Snuhi (Euphorbia nerifolia) latex is very difficult and time taking process. The main complaints reported by the patients are pain and discomfort during the course of treatment with Ksharasutra for Bhagandara, which requires management with oral analgesics. Considering the above problems, a non irritant preparation such as Krutamalakadya Varti mentioned in Sushruta Samhita in the chapter of Bhagandara Chikitsa Adhyaya is modified in the form of Krutamalakadya Sutra which contains following ingredients such as Aragvadha, Haridra, Ahimsra, Madhu and Ghrita is taken for the study. Krutamalakadya Sutra is also having a good binding property, as well as Chedana, Bhedana, Lekhana, Vedanasthapana, Vrana Shodhana and Vrana Ropana properties. A total of 30 subjects were taken, Trial group treated with Krutamalakadya Sutra and control group treated with Apamarga Ksharasutra. The study shows that preparation of Krutamalakadya Sutra is much easier than Apamarga Ksharasutra and had high efficacy in subjective parameters like burning sensation compared to Apamarga Ksharasutra.
Application of Women’s Representation As Election Supervisors in the Election Supervisory Board in the Indonesian Election Law
Authors: Muharam Ricky Santoso , Pradhanawati Ari , Fitriyah Fitriyah , Supratiwi Supratiwi
Published: February 2024

This study analyses the application of women's representation as election supervisors and election supervisors who are part of election organizers other than the General Elections Commission. The Election Supervisory Board (Bawaslu) is an election organizer with the authority and responsibility to oversee the process of election stages and election participants. This study uses a qualitative approach by using secondary data from the Bawaslu Decree of the Republic of Indonesia and primary data from the regulation of Law No. 7 of 2017 concerning general elections, journals, internet and social media from Bawaslu agencies, both from Bawaslu RI, Province, and Bawaslu Regency/City. Then, conclude using descriptive analysis techniques. The results of this study show that the implementation of women's representation in the election supervisory institution, namely Bawaslu, does not meet the women's representation requirement of 30%. Even in some districts/cities, women are not represented as election supervisors. Article 92 Paragraph 11, as a legal basis regarding women's representation in Bawaslu, is not fully implemented. Regulations are not only used as an obligation abort as a condition for women's entry into politics that have been given places and rules. In addition, implementation and supervision in the field are needed. There needs to be integrity and transparency from the selected selection team with no political content that benefits one candidate. However, due diligence and appropriateness are in the realm of Bawaslu of the Republic of Indonesia.
Analysis of Research Trends on Older Adults with Hearing Loss in Korea: Using the ICF Core Set
Authors: Cho Soo Jin , Lee Mi Sook , Lee Yu Ri
Published: February 2024

Purpose: This study aimed to analyze trends of research on older adults with hearing loss, based on the framework of the International Classification of Functioning, Disability and Health (ICF) core set for hearing loss in Korea, and to present implications for the direction and challenges of research on older adults with hearing loss in the future. Methods: A total of 54 studies related to older adults with hearing loss, published in academic journals from 2000 to July 2023 in Korea, were analyzed.Results: In the analysis of research methods, quantitative studies accounted for 97.0%, among which survey studies accounted for 56.7%, more than experimental studies. As a result of the analysis by research theme, studies related to ‘quality of life and satisfaction (21.1%)’ and ‘psychological and emotional characteristics (18.3%)’ were frequent. As a result of the analysis by the classification of the ICF core set, among the components of the ICF, studies related to ‘activities and participation’ and ‘body functions’ were the most. By subcategory, ‘hearing functions (12.0%)’ and ‘emotional functions (11.7%)’ of the body functions sub-area, and ‘listening (10.9%)’ of the activities and participation subarea were frequent.Conclusion: The results of this study will be useful as a foundational reference for the evaluation of hearing impairments of older adults with hearing loss, the development of hearing rehabilitation programs, and the establishment of various health and welfare policies.
Validity and Reliability of Age-Related Hearing Loss Questionnaire in Korean Elderly
Authors: Kang Dong Woo , Lee Seok Hong , Choi Chul-Hee
Published: February 2024

Purpose: The objective of this study is to investigate the validity and reliability of the Age-Related Hearing Loss Questionnaire (ARHLQ) for Korean elderly, originally developed by Choi, to evaluate the communication difficulties faced by Korean elderly individuals with hearing loss everyday life. The ARHLQ consists of twenty-three questions in four subcategories of communication difficulties (9 items), communication environment (5 items), emotion and other’s reaction (6 items), and communication strategy (3 items).Methods: The ARHLQ was administrated to a total ninety subjects composed of three or four subject groups based on mild, moderate, moderate severe, and severe hearing loss determined by the pure tone threshold average (PTA) and high frequency threshold average (HFPTA), with an average age with the age of 77.22 ± 6.36 years old. Validity and reliability were calculated using Pearson’s correlation coefficient, the Kruskal-Wallis test for nonparametric independent samples, and Cronbach alpha coefficient.Results: Pearson’s correlations coefficients between total scores and four subcategories of ARHLQ were high ranging from 0.813 to 0.971 and the correlation coefficient between ARHLQ and the Korean Hearing Handicap Inventory for the Elderly (K-HHIE) was high (0.736). The correlation coefficients between four subcategories of ARHLQ and the two subcategories of K-HHIE were high ranging from 0.598 to 0.770. The mean difference in total score and four subcategories of ARHLQ by the hearing degrees of PTA and HFPTA were significantly observed. For internal consistency, Cronbach’s alpha coefficient in total scores and four subcategories was high ranging from 0.807 to 0.966. The test-retest correlation for reliability was very high (0.996).Conclusion: These findings suggest that the ARHLQ is a clinically useful tool to evaluate age-related hearing loss according to the degree of hearing loss.
Exploring the Perspectives of Patients Living With Lupus: Retrospective Social Listening Study
Authors: Spies Erica , Andreu Thomas , Hartung Matthias , Park Josephine , Kamudoni Paul
Published: February 2024

Background

Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease affecting various organs with a wide range of clinical manifestations. Cutaneous lupus erythematosus (CLE) can manifest as a feature of SLE or an independent skin ailment. Health-related quality of life (HRQoL) is frequently compromised in individuals living with lupus. Understanding patients’ perspectives when living with a disease is crucial for effectively meeting their unmet needs. Social listening is a promising new method that can provide insights into the experiences of patients living with their disease (lupus) and leverage these insights to inform drug development strategies for addressing their unmet needs.

Objective

The objective of this study is to explore the experience of patients living with SLE and CLE, including their disease and treatment experiences, HRQoL, and unmet needs, as discussed in web-based social media platforms such as blogs and forums.

Methods

A retrospective exploratory social listening study was conducted across 13 publicly available English-language social media platforms from October 2019 to January 2022. Data were processed using natural language processing and knowledge graph tagging technology to clean, format, anonymize, and annotate them algorithmically before feeding them to Pharos, a Semalytix proprietary data visualization and analysis platform, for further analysis. Pharos was used to generate descriptive data statistics, providing insights into the magnitude of individual patient experience variables, their differences in the magnitude of variables, and the associations between algorithmically tagged variables.

Results

A total of 45,554 posts from 3834 individuals who were algorithmically identified as patients with lupus were included in this study. Among them, 1925 (authoring 5636 posts) and 106 (authoring 243 posts) patients were identified as having SLE and CLE, respectively. Patients frequently mentioned various symptoms in relation to SLE and CLE including pain, fatigue, and rashes; pain and fatigue were identified as the main drivers of HRQoL impairment. The most affected aspects of HRQoL included “mobility,” “cognitive capabilities,” “recreation and leisure,” and “sleep and rest.” Existing pharmacological interventions poorly managed the most burdensome symptoms of lupus. Conversely, nonpharmacological treatments, such as exercise and meditation, were frequently associated with HRQoL improvement.

Conclusions

Patients with lupus reported a complex interplay of symptoms and HRQoL aspects that negatively influenced one another. This study demonstrates that social listening is an effective method to gather insights into patients’ experiences, preferences, and unmet needs, which can be considered during the drug development process to develop effective therapies and improve disease management.
Global Burden of Viral Skin Infections from 1990 to 2019: Risk factors associated with burden of disease (Preprint)
Authors: Kulkarni Vishnutheertha , Mojica Isaiah , Grewal Tjinder , Liu David , Lio Peter
Published: February 2024

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Technical Efficiency Analysis Of Home Industry Kamang Crackers In Kenagarian Kamang Hilir Kamang Magek District, Agam Regency West Sumatra Province
Authors: Sari Silvi Permata , Romdhon Muhamad Mustopa , Utama Satria Putra
Published: February 2024

Technical efficiency is the ability of an industry to use minimum total input to produce maximum output. This research aims to 1) Analyze the level of technical efficiency in the Kamang cracker home industry in Kamang Hilir Kenagarian, and 2) Analyze what factors influencing the level of technical efficiency in the Kamang cracker home industry in Kamang Hilir Kenagarian. This research was carried out deliberately in Kenagarian Kamang Hilir, Kamang Magek District, Agam Regency. Respondents in this study using the Slovin formula, totaling 51 Kamang cracker home industry entrepreneurs using a simple random sampling technique. Using primary and secondary data, while the data analysis used is qualitative descriptive analysis and the Cobb-Douglass production function method which is converted into logarithmic form, then data analysis uses Stochastic Frontier. The analysis results showed that the average level of technical efficiency was 0.5792, proving that the hypothesis in this research was proven correct. Can be concluded that the Kamang cracker home industry is technically efficient and the factors that influence technical efficiency are raw materials, salt, hours people work, age, number of family members while green onions, pertalite and gas fuel, education, business experience are not significant in the Kamang cracker home industry
Customer Segmentation
Authors: Shah Ishita
Published: February 2024

Abstract: Effective marketing involves targeting specific customer groups with personalized products, services, and campaigns, making customer segmentation a crucial strategy in modern business. This paper introduces a pioneering customer segmentation method that utilizes machine learning techniques to accurately and efficiently segment customers based on their behaviors, demographics, and transaction history. By combining transfer learning, Rfm (recency, frequency, monetary) modeling, and clustering algorithms like K-means, our approach generates meaningful customer segments, offering valuable insights for personalized marketing and improved customer experiences. We showcase the positive impact of our method on a real-world dataset, displaying noteworthy enhancements in marketing effectiveness and customer satisfaction.
A Critical Review on Kuchladi Yog
Authors: Meena Kamlesh Kumar
Published: February 2024

Kuchladi Yog is an Ayurvedic drug mentioned in Siddha Bhaisjya manimala. The main content of Kuchladi Yog is purified kuchla and Arkmul indicated in addiction.1 Kuchladi yog as an appetite stimulant and also effective in treating various diseases of the heart, including anxiety, insomnia, epilepsy, psychosis, memory loss, depression, and disorders of the nervous system. Method-A Critical review on kuchladi yog from various Ayurved and Modern classics books, texts, research, journals and recently published books.
Ocio e industrias culturales en el espacio iberoamericano, 1820-1945
Authors: Dias Cleber
Published: February 2024

La obra apuesta por un empleo más riguroso de la noción de «Ocio», y por una visión de las industrias culturales que supere su visión exclusivamente manipuladora. Sin negar evidentemente su poder, y examinando la formación de grandes mercados culturales y oligopolios poderosos, este estudio descubre también reductos de resistencia y formas de cultura popular opuestas al empuje de las industrias culturales modernas. El suyo será, finalmente, un espacio de constante negociación, transferencia y conflicto entre grupos ideológicos, minorías sociales y políticas, o potentes grupos empresariales configurado como un terreno privilegiado para las luchas, el control o las resistencias frente a los poderes políticos o sociales. En sus páginas no se ignoran, bien al contrario, las dimensiones de internacionalización y de configuración de culturas comunes en el espacio iberoamericano, pero se asume también la necesidad de superar visiones domésticas y enfoques limitadamente nacionalistas. De esta forma, mientras que parte de sus contenidos exploran la evolución de algunos mercados nacionales particularmente activos en la construcción de industrias culturales viables en el espacio iberoamericano hasta la Segunda Guerra Mundial, se acogen también estudios que muestran en capítulos como la industria editorial, el deporte o la música popular, el vigor de dinámicas comunes en el espacio ibérico y latinoamericano