bluuebunny/crossref_metadata_2025 huggingface dataset:
Concepções da saúde sexual e reprodutiva entre mulheres curipacas em situação de mobilidade humana
Authors: Fandiño Osorio Vilma Cenit , Velásquez Jiménez Claudia Marcela , Sarmiento Medina María Inés , Vargas Cruz Sandra Lucia , Puerto Miryam Beatriz
Published: August 2024

Resumo A migração dos povos indígenas apresenta tensões entre as tradições ancestrais e a visão ocidental com implicações para a saúde pública, especialmente a saúde sexual e reprodutiva. Este texto teve como objetivo analisar as concepções de saúde sexual e reprodutiva de mulheres indígenas curipacas de uma reserva indígena no departamento de Guainía (Colômbia). Trata-se de um estudo de caso, com uma amostra de 40 mulheres indígenas curipacas, residentes na reserva Paujil, em Guainía, provenientes de diferentes comunidades. Foram aplicadas entrevistas semiestruturadas elaboradas com membros da mesma comunidade e traduzidas para a língua curipaca. Três categorias resultaram da análise: impacto da mobilidade de mulheres indígenas; autonomia relativa como estrutura da sexualidade; e concepções da abordagem ocidental da saúde sexual e reprodutiva. Esta última categoria identificou que as participantes não têm conhecimento sobre a saúde sexual e reprodutiva desde o ponto de vista ocidental e vislumbram suas próprias formas de compreender a saúde-doença como parte integrante de todas as dimensões da vida/morte. A inter-relação entre as tradições ancestrais dos povos indígenas e a visão ocidental sobre a saúde requer uma abordagem intercultural de profissionais, serviços e do sistema de saúde para que reconheça a autonomia pessoal e relacional desses povos.
Um olhar sobre as promessas não cumpridas da Reforma Sanitária Brasileira: reflexões à luz das teorias decolonial e feminista negra
Authors: Lopes Arthur da Silva
Published: August 2024

Resumo Por meio de um esforço analítico-interpretativo de releitura dos fatos históricos apresentados acerca da ideia, da proposta, do movimento e do processo da Reforma Sanitária Brasileira (RSB), e à luz das teorias e críticas decolonial e feminista negra, este artigo de cunho ensaístico tem como objetivo propor um giro epistemológico e político para uma práxis sanitária decolonial. Em um primeiro momento, reflete acerca de alguns pontos de incoerência de certas dimensões da RSB que possivelmente contribuíram para que houvesse promessas não cumpridas em sua proposta. Na segunda parte do trabalho, (re)posiciona a analítica concernente à situação de colonialidade no Brasil com relação ao que está em jogo, na tentativa de “redemocratizar a vida” neste país. Finalmente, evidencia-se que, apesar de haver muito a avançar, asseguradamente a RSB não é um “movimento desnaturado”.
Factors stimulating the hatching of resting eggs and their contribution to the composition of cladoceran assemblages in tropical temporary lagoons
Authors: Guimarães Wesley Luiz , Panarelli Eliana Aparecida , Santos Natan Guilherme dos , Castilho-Noll Maria Stela Maioli
Published: August 2024

Abstract: Aim We aimed to verify the contribution of cladocerans’ resting eggs to the active communities of temporary lagoons and, through an experiment, identify which conditions induce high hatching rates. Methods Cladocera assemblages were sampled in four temporary lagoons in the Turvo River floodplain (20° 22’S and 49° 16’W), in the northwest region of São Paulo State, Brazil. Sediment samples were taken during the dry season from a depth of 5 cm, using a 4.5 cm diameter corer. Plankton samples were taken from the water column before and after the dry season. For the hatching test, two treatments were performed 1. Natural condition – without light and temperature control; 2. Controlled condition – with controlled photoperiod and temperature. Temperature, pH, conductivity, dissolved oxygen and hatching of resting eggs were monitored for two weeks. The influence of the parameters on hatching in both treatments was evaluated using Hierarchical Partition Analysis. Results Hatching of resting eggs was higher in the Controlled condition than in the Natural one. Thirty percent of species observed in the active community after flooding hatched in the laboratory test. Conductivity, pH, and dissolved oxygen were positively correlated to the hatching of some species, e.g., Ephemeroporus hybridus, Leydigiops ornata, Notoalona sculpta and Ilyocryptus spinifer. The first species to hatch were those living associated with macrophytes and at low depths. Conclusions Our results show that stable temperature and photoperiod with similar light and dark hours stimulate greater hatching of Cladocera resting eggs. Variables such as pH, conductivity and dissolved oxygen were also correlated with the hatching of some species. We observed that the first contributions to activating the community after drought came from hatching of species usually associated with macrophytes and low depth conditions.
Brickwork in Norway: tradition encounters a new age of industrial construction, 1905–1912
Authors: Haupt Thomas
Published: August 2024

During the first decades of the twentieth century, construction technology experienced rapid developments, which also affected industrial buildings. This paper demonstrates this evolution between 1905 and 1912 through the case of the Rjukan and Notodden UNESCO World Heritage site in central southern Norway. The site was established for the purpose of producing synthetic nitrogen fertiliser by the company Hydro. There, building systems changed from timber frames with brick infill to pure brick bearing walls and finally to more sophisticated wall-braced cage buildings where steel was incorporated. Increasing the structural capacity was the answer to the growing demand for higher and larger industrial buildings. This case study presents the characteristics and establishes an initial account of the types of construction systems. Embedded steel that is concealed within brickwork can be subject to corrosion and compromise structural integrity. Studying these systems and materials in greater detail and identifying conservation issues will support future repair work. The studied buildings reveal also that used systems were not unique to this remote mountain area, but the technology used was in line with developments in leading industrial nations around the world. This places the site also in an international context of architecture and engineering history.
ST2+ T-Regulatory Cells in Renal Inflammation and Fibrosis after Ischemic Kidney Injury
Authors: Sabapathy Vikram , Price Airi , Cheru Nardos Tesfaye , Venkatadri Rajkumar , Dogan Murat , Costlow Gabrielle , Mohammad Saleh , Sharma Rahul
Published: August 2024

Key Points

IL-33/ST2 alarmin pathway regulates inflammation, fibrosis, and resolution of ischemia-reperfusion injury of kidneys.

ST2 regulates the transcriptome of T-regulatory cells related to suppressive and reparative functions.

The secretome of ST2+ T-regulatory cells regulates hypoxic injury in an amphiregulin-dependent manner.

Background

Inflammation is a major cause of kidney injury. IL-1 family cytokine IL-33 is released from damaged cells and modulates the immune response through its receptor ST2 expressed on many cell types, including regulatory T cells (Tregs). Although a proinflammatory role of IL-33 has been proposed, exogenous IL-33 expanded Tregs and suppressed renal inflammation. However, the contribution of endogenous IL-33/ST2 for the role of Tregs in the resolution of kidney injury has not been investigated.

Methods

We used murine renal ischemia-reperfusion injury and kidney organoids (KDOs) to delineate the role of the ST2 and amphiregulin (AREG) specifically in Tregs using targeted deletion. Bulk and single-cell RNA sequencing were performed on flow-sorted Tregs from spleen and CD4 T cells from postischemic kidneys, respectively. The protective role of ST2-sufficient Tregs was analyzed using a novel coculture system of syngeneic KDOs and Tregs under hypoxic conditions.

Results

Bulk RNA sequencing of splenic and single-cell RNA sequencing of kidney CD4 T cells showed that ST2+ Tregs are enriched for genes related to Treg proliferation and function. Genes for reparative factors, such as Areg, were also enriched in ST2+ Tregs. Treg-specific deletion of ST2 or AREG exacerbated kidney injury and fibrosis in the unilateral ischemia-reperfusion injury model. In coculture studies, wild-type but not ST2-deficient Tregs preserved hypoxia-induced loss of kidney organoid viability, which was restored by AREG supplementation.

Conclusions

Our study identified the role of the IL-33/ST2 pathway in Tregs for resolution of kidney injury. The transcriptome of ST2+ Tregs was enriched for reparative factors including Areg. Lack of ST2 or AREG in Tregs worsened kidney injury. Tregs protected KDOs from hypoxia in a ST2- and AREG-dependent manner.
Tendencia al escándalo como estrategia de marketing en moda textil: el caso Zara
Authors: Alegría-Varona Gonzalo Ricardo , Benites-Alejandría Carlos Enrique
Published: August 2024

the last decade, various unorthodox tactics have gained prominence, notably the use of scandal. This article seeks to demonstrate the existence of a tendency to scandal as a marketing strategy developedby the Zara brand during the decade from 2014 to 2023; and demonstrate that it is correlated with increased sales. Using a mixed methodology, a case study is carried out based on content analysis by designing a database on ten Zara launches, at the rate of one product per year in the last decade. These launches stood out for their countercultural advertising aimed at certain consumer segments. Furthermore,the multivariate correlation between sales and scandal factors was calculated. The results showthe trend towards the brand’s annual scandal through tables and data triangulation, supported by graphs that represent the level of annual sales, the volume of followers on social networks, news of scandals and geographical distribution. The study concludes that the Zara brand used controlled scandal as a marketing strategy in the last decade. This tactic is characteristic of the network society, which bases itsdecisions on recommendations or events rather than on traditional advertising, thus achieving a higheffectiveness ratio.
Fiber Photometry on Noradrenergic/Dopaminergic Neurons (Open Field) v1
Authors: González-Cabrera Cristian , Prigge Matthias
Published: August 2024

The goal is to monitor in vivo calcium activity in noradrenergic and dopaminergic neurons within the hindbrain and midbrain of mice using fiber photometry during an open-field setup.
Pollen germination on wheat stigmas v1
Authors: Millán Blánquez Marina
Published: August 2024

Aniline blue staining of pollen tube growth on the wheat stigma and through the style 4 h and 30 min after pollination.
Application of ALFA-tag and tyramide-based fluorescence signal amplification to expand the CRISPR-based DNA imaging toolkit v1
Authors: Prakash Potlapalli Bhanu , Fuchs Joerg , Rutten Twan , Meister Armin , Houben Andreas
Published: August 2024

Understanding the spatial organization of genomes within chromatin is crucial for deciphering gene regulation. In this protocol we describe application of an ALFA-tagged dCas9 protein in combination with aA. thaliana centromere-specific gRNA and a fluorescence-labeled NbALFA nanobody to label centromere-specific sequences in fixed Arabidopsis thaliana nuclei. The dCas9 protein possessing multiple copies of the ALFA-tag, in combination with a minibody and fluorescence-labelled anti-rabbit secondary antibody, resulted in enhanced target-specific signals. Furthermore, we describe the combination of the highly sensitive Tyramide Signal Amplification (TSA) method with CRISPR-FISH.
The New EU Industrial Policy: Opening Up New Frontiers for Financial Capital
Authors: Wigger Angela
Published: August 2024

The EU has implemented a whole array of industrial policy programmes over the past decade to bolster the competitiveness of selected knowledge-intensive industries and to induce a digital and green transition. Responding to shifting competitive challenges in global capitalism, and the adoption of industrial strategies by other major economies, the new EU industrial policy seeks to onshore manufacturing capacity in sectors of geoeconomic importance, and simultaneously reduce dependencies on global value chains. Drawing on a historical materialist perspective, this article historizes and contextualises the financing strategies adopted within EU industrial policy. Faced with tight budgetary constraints, and deficit spending not being an option at the EU level, unlocking private investment takes centre stage, such as by tapping into capital markets or using member state aid or EU structural funds as a precursor, as well as by incentivising private investments through risk-absorbing financial instruments that rely on the EU budgetary resources. As will be shown, the EU has been experimenting with such risk-absorbing financial gimmicks for industrial policy purposes since the 1990s; yet, their usage has reached unprecedented levels with the heightened geoeconomic tensions since the 2008 and Covid-19 crises. The article demonstrates moreover that organised factions within financial and industrial capital have actively advocated for public safeguards, and that their deployment thus is not merely a functionalist response to shifting power dynamics or a desperate last resort in the absence of a supranational fiscal policy.
Prospective comparative study of medial parapatellar and medial subvastus approaches in total knee arthroplasty
Authors: Badawi I.A. , Ismail A.S. , Waly A.H. , Khalkaf M.A.N.
Published: August 2024

Introduction Total knee arthroplasty (TKA) is the treatment of end-stage osteoarthritis in patients who failed to respond to conservative treatment in providing significant pain relief and improving joint function. The medial parapatellar approach (MPP) allows adequate patellar eversion and sufficient knee flexion to expose the knee joint, but the incision through the quadriceps tendon may impair the extensor mechanism of the knee post-operatively. The subvastus approach (SV) completely spares both the quadriceps tendon and muscle and provides adequate exposure of the knee joint for the replacement procedure, SV maintains integrity of the patellar blood supply and reduces post-operative pain resulting in shorter hospital stay.

The aim of this prospective study was to compare the results of the medial parapatellar and subvastus approaches in primary total knee arthroplasty (TKA) regarding postoperative pain, recovery of muscle strength, range of knee motion and return to regular daily activities.

Materials and Methods Sixty patients underwent TKA at El-Hadara university hospital in Alexandria. The medial parapatellar apphroach (MPP) was performed in 30 patients while the subvastus approach (SV) was used for the other 30 patients. The choice of approach was randomly assigned.

Results The statistical analysis of the results at the end of a 6-month follow-up showed that there were no significant differences between the patients in group 1 (MPP) and group 2 (SV) with respect to age, gender, comorbidity, side operated or body mass index (BMI). Regarding the functional knee scores (IKDC, WOMAC), there were no differences at 4 weeks, 3 months and 6 months postoperatively between the two groups. However, we found better outcomes in the SV group regarding the VAS score during the first five postoperative days, earlier quadriceps recovery by assessment of Straight Leg Raising test (SLR), while the operative time was longer in the SV group with less blood collected postoperatively in hemovac drain in the same group.

Discussion In our study during the operation via the MPP approach, the index suture positioned at the superomedial border of the patella and the opposite suture on the medial retinacular flap had enabled the surgeon to avoid patellar maltracking during closure of the wound. In the SV group, the L-shaped incision of the medial capsule was considered an efficient landmark for accurate soft tissue closure avoiding the patellar maltracking.

Conclusion The subvastus approach offers the advantage of keeping the integrity of quadriceps muscle and the extensor mechanism remains intact post-surgery. It causes less pain and less blood loss postoperatively than the regular parapatellar approach. The patient could recover the knee function in a shorter time with fewer complications, which is greatly in line with the concept of ERAS (Enhanced Recovery After Surgery).
Risk factors associated with congenital clubfoot in children
Authors: Vlasov M. V. , Musikhina I. V.
Published: August 2024

Introduction Congenital clubfoot is a frequent malformation of the lower extremities. However, the causes of this pathology in children are still unclear. The identification of the factors associated with congenital clubfoot is a relevant problem, the solution of which will allow a prenatal prevention of clubfoot in newborns thus reducing the number of patients with this pathology.

Purpose The search for possible risk factors leading to a violation of foot development in the fetus and their significance in the occurrence of congenital clubfoot in children.

Materials and methods The study was of retrospective nature and was carried out in pairs “Mother-Newborn”. It included examination of 149 children. The first group (n = 97) was compiled by the “Mother Newborn” pairs, in which the child had a typical form of congenital clubfoot; the second group (n = 52) were pairs in which the baby was healthy. The data obtained were processed using tables 2×2 and logistics regression.

Results According to the results of the study, it was found that the greatest sensitivity and specificity of congenital clubfoot was associated with the external factor of nicotine dependence in pregnant women (SE = 0.32; SP = 0.90) and the factor of hereditarily burdened congenital foot pathology in close relatives (SE = 0.16; SP = 0.98). An acute respiratory viral infection in the anamnesis, anemia in a pregnant woman or toxicosis did not show statistically significant causal connection with the occurrence of congenital clubfoot according to the analysis using the method of logistics regression (р > 0.05) and they should not be used as prognostic ones.

Discussion The data obtained by us on the paramount significance of the two “risk” factors of the congenital clubfoot development (nicotine dependence in a pregnant woman and hereditarily burdened disorder of congenital foot pathology among close relatives) were reflected only in a few scientific sources.

Conclusion The risk factors of the greatest sensitivity, specificity and causal relationship with the congenital clubfoot development were associated with the adverse effects of the external factor of nicotine dependence during pregnancy and burdened heredity associated with congenital foot pathology in close relatives (р < 0.05).
Comparative analysis of surgical treatment results for osteoporotic burst fractures of thoracolumbar vertebral bodies
Authors: Sinyavin V. D. , Rerikh V. V.
Published: August 2024

Introduction Surgical methods for osteoporotic burst vertebral body fracture repair have their advantages and shortcomings. The use of circumferential stabilization and corrective vertebrotomies in elderly patients is highly invasive and carries great surgical risk. On the other hand, minimally invasive methods lead to recurrence of the deformity. Thus, in the treatment of patients with such pathology, it is necessary to choose a surgical method that allows achieving optimal results.

Purpose of the work was to compare the results of surgical treatment for osteoporotic burst fractures in thoracolumbar vertebral bodies using the developed method and methods of circular and hybrid stabilization based on clinical and radiological criteria.

Materials and methods The study was retrospective. Three groups of patients were formed according to the type of surgical intervention. Inclusion criteria were patients with primary osteoporosis who did not receive osteotropic therapy before surgery, with osteoporotic fractures (type OF3 and OF4) of the vertebral bodies of the thoracolumbar location (Th10–L2). The follow-up period was 12 months. The following criteria were assessed: the amount of kyphosis correction (according to the Cobb method), the amount of residual postoperative kyphotic deformity, as well as its recurrence in the long-term postoperative period; sagittal balance of the torso (Barrey index), subjective evaluation of the patient’s condition (VAS). Quality of life assessment was not performed.

Results There were no statistically significant differences in the dynamics of sagittal balance during the follow-up period between the groups (p > 0.99). There was no difference between groups in clinical outcomes (VAS) at follow-up (p > 0.05). A statistically significant difference in the magnitude of kyphotic deformity and its correction in the specified postoperative periods was revealed between the hybrid fixation groups and the corrective vertebrotomy group. No difference was found with the circular stabilization group.

Discussion Due to the high risks of poor outcomes of anterior spinal fusion, in particular, implant subsidence, to avoid anterior spinal fusion, we used a method of focal kyphosis correction and posterior spinal fusion with autologous bone. The method proposed by the authors for the correction of focal kyphotic deformity in the treatment of patients with osteoporotic burst fractures of the vertebral bodies combines satisfactory correction of focal kyphosis with minimal surgical invasiveness, which reduces the risks of complications and poor outcomes. The proposed method may also be combined with hybrid fixation.

Conclusion The developed method for focal kyphotic deformity correction in the treatment of osteoporotic burst fractures of vertebral bodies provides satisfactory correction of focal kyphosis, reduces the risks of complications and poor outcomes in comparison with circular and hybrid stabilization.
Periprosthetic joint infection in patients with rheumatoid arthritis: case series
Authors: Lyubimova L. V. , Pchelova N. N. , Nikolaev N. S. , Preobrazhenskaya E. V. , Lyubimov E. A.
Published: August 2024

Introduction The differential diagnosis of periprosthetic joint infection (PJI) is challenging in patients with systemic diseases due to identical clinical and laboratory patterns and activity of the inflammatory process.

The objective was to evaluate the diagnostic data and results of debridement of PJI in patients with rheumatoid arthritis using a case series.

Material and methods A retrospective analysis of surgical treatment of PJI was produced in patients with rheumatoid arthritis between 2014 and 2022. PJI was verified based on ICM criteria. A poor outcome included the presence of clinical and laboratory signs of infection on admission to the second stage of treatment and recurrence after successful debridement.

Results Among the 524 cases of PJI, 35 (6.7 %) were patients with rheumatoid arthritis with 48.6 % receiving antibiotics prior to admission. Culture-negative infection was recorded in 38.4 %. PJI was not confirmed in five cases (14.3 %). High average values of inflammatory markers were registered in the blood (ESR, CRP and D-dimer) before and after debridement; decreased ESR and leukocyte count in the synovial fluid was statistically significant. Favorable outcomes were obtained in 82.9 % of cases at mid term with every fifth patient treated with a spacer or arthrodesis.

Discussion The incidence of culture-negative infection in patients with systemic diseases was reported as much as 27–37 %. A systematic review of the literature showed that the percentage of band neutrophils in synovial fluid has a sensitivity of 95.2 % and a specificity of 85.0 %, with an optimal threshold of 78 % sufficient to verify infection. The poor outcomes we identified resulted from two- or three-stage surgical treatment. Other authors reported better outcomes with two-stage debridement.

Conclusion Culture-negative infection was common in cases of PJI observed in patients with rheumatoid arthritis. Favorable outcomes were seen mostly with two-stage surgical treatment. Inflammatory markers ESR, CRP and D-dimer did not reach normal values during diagnosis and treatment of infection indicating the inapplicability of standard diagnostic criteria for PJI in patients with rheumatoid arthritis.
Evaluation of the effect of osteosynthesis wires on the structural reorganization of metaepiphyseal cartilage (an experimental and morphological study)
Authors: Korobeinikov A. A. , Stupina T. A. , Dyuryagina O. V. , Stepanov M. A. , Antonov N. I.
Published: August 2024

Introduction Premature arrest of bone growth is the most common complication of bone fractures at the growth plate level.

The purpose of the work was to evaluate the structural reorganization of metaepiphyseal cartilage following its direct injury with metal and biodegradable wires in an experiment.

Materials and methods The metaepiphyseal cartilage of the distal femur of 18 lambs of both sexes was studied. The age of the animals at the beginning of the study was (43.92 ± 0.8) days, by 60 and 120 days (102.63 ± 0.82) and (161.1 ± 0.9) days, respectively. The animals underwent transphyseal insertion of wires/ pins: series 1 — Kirschner wires, series 2 — titanium wires, series 3 — poly-L-lactic acid pins. The duration of the experiment was 60 and 120 days. Clinical and radiographic studies were carried out. Histomorphometry was performed using an AxioScope.A1 microscope and Zenblue software (CarlZeissMicroImagingGmbH, Germany).

Results Reactive changes in the growth plate at the interface with the wire were manifested by proliferation of chondrocytes in the zone of proliferating cartilage and in the reserve zone; the minimally expressed changes were noted in series 2, the most pronounced were in series 1. By the end of the experiment, at the interface with the wire in series 1, blood vessels penetrated into the metaepiphyseal cartilage; in series 3 the amount of the fibrous component was increased, which indicates further formation of “bone bridges” and “fibrous bridges,” respectively. In undamaged areas of the growth plate in all series, the zonal structure was preserved. By the end of the experiment, increased values of the thickness of the metaepiphyseal cartilage were noted (1.2 times higher than the control), differences between series were a tendency; in series 2 and 3 the ratio of metaepiphyseal cartilage zones was comparable to the control; in series 1 the proportion of the proliferating cartilage zone was increased by 4 %.

Discussion The main problem with growth plate injuries is the formation of bone tissue or fibrosis, which affects the growing process. Currently, the question of choosing a treatment tactic for growth plate injury depending on the size of the “bone bridges” is debatable. Relevant are future comparative studies of the regeneration of metaepiphyseal cartilage defects after the use of fixators made from different materials.

Conclusion Histomorphometric characteristics of the growth zone reliably showed that the insertion of wires, regardless of their material, was not accompanied by inhibition of the bone-forming function of the distal metaepiphyseal cartilage of the femur.
Achilles tendon regeneration after experimental transverse tenotomy with preserved peritenon and the structures
Authors: Vlasov M. V. , Shirokova N. Yu. , Musikhina I. V.
Published: August 2024

Introduction The Ponseti method is the first choice for congenital clubfoot with the possibilities of transverse tenotomy being underexplored in repair of the Achilles tendon in pediatric patients.

The objective was to identify specific features of the Achilles tendon repair after experimental transverse intersection and preserved peritenon, vessels and nerves of growing rabbits.

Material and methods The experimental study included 20 Chinchilla rabbits of both sexes aged 1.0–1.5 months used as a biomodel with a weight of 1476.0 ± 114.3 g. Rabbits were sacrificed in groups of five by air embolism under local anesthesia at 15, 30, 60 and 90 days of surgery.

Results The tendon defect zone was represented by small areas of dense fibrous scar tissue with some cellular fibroblasts, and tendon fibers of unremarkable architectonics arranged in a mutually parallel waves could be seen in the layers of connective tissue at 90 days. The thickness of the first-order collagen fibers increased to 8.9 ± 1.32 µm and comparison with the normal value of 9.2 ± 1.88 µm showed no statistically significant difference (p = 0.38). The thickness of the second-order collagen fibers increased to 28.1 ± 1.28 µm during the time, and comparison with the standard measurements of 28.3 ± 2.23 µm demonstrated no statistically significant difference (p = 0.64).

Discussion According to the literature, the ability of the tenoblast to synthesize structural proteins and regulatory biomolecules after injury decreases with age and leads to fibrous restoration of the tendon and formation of a permanent scar. Our study on growing rabbits showed that the organotypic structure of the experimental tendon restored at the intersection site at 60 days with the Achilles tendon defect being represented by the tendon-like tissue at 90 days.

Conclusion The Achilles tendon was shown to regenerate in optimal conditions after the dissection and preservation of the peritenon, vessels and nerves with tendon tissue being formed within a short time (3 months after the intervention) being identical to the original.
Nerve injury associated with shoulder surgery
Authors: Tuturov A. O. , Petrosyan A. S. , Panin M. A. , Zakharyan B. I. , Al-Bawareed O.
Published: August 2024

Introduction Progress in shoulder surgery is associated with improved operating rooms equipment, advanced surgical products and minimally invasive techniques. There are rare injuries to nerves and vessels being intersected or pulled into the sutures. However, marginal tears, compression and nerve entrapment of trunks during access retraction, catheterization, inadequate correct of the patient on the operating table and errors in rehabilitation can be common.

The purpose was to identify factors predisposing to peripheral nerve injury to the upper limb during shoulder surgery and offer prevention options.

Material and methods Major studies in the field of shoulder anatomy and surgery published between 1984 and 2023 were reviewed to identify anatomical, biomechanical and perioperative factors leading to peripheral nerve injuries. The original literature search was conducted on key resources including GoogleScholar, PubMed, ScienceDirect, RSCI, Scopus. Four approaches were used for structuring and informative presentation of the data to include types of the peripheral nerve injury in the upper limb.

Results and discussion Factors predisposing to the peripheral nerve injury in the upper limb during shoulder surgery were identified in the review. Prevention measures include the patient positioned on the operating table with adequate fixation of the head and torso, regardless of the chosen position; traction of the involved upper limb with a load of not greater than 9 kg using a specialized clamp; preoperative marks of the surgical field and staining of bone landmarks; the arthroscopic ports 1–2 cm to be shifted more distally minimizing the fluid flow into the joint during a long operation. Postoperative consultation with rehabilitation specialists is essential to develop an early activation program and assess the risks of neurological disorders.

Conclusion The shoulder anatomy and the localization of unsafe zones of the shoulder, the risks associated with a particular manipulation were explored for effective preoperative planning and prevention of neurological complications in the treatment of surgical pathology of the shoulder joint.
Asociatividad, liderazgo y visión organizacional. Una mirada desde la perspectiva de los asociados en organizaciones de recicladores
Authors: Suárez-Pineda Marlén , Bacca-Buitrago Laura Michelle
Published: August 2024

This research aimed to understand those aspects that correspond to the social constructions in the organizational reality of the associations of professional recyclers, understood as the people who are involved in the activities of recovery, sorting, collection, and transportation of solid waste, to finally incorporate them into a new productive cycle. Given the associative nature of these organizations, their sustainability depends on the capacity of their members to find meaning in their associativity, exercise leadership and share a long-term vision. The work is spatially located in the city of Tunja and has a synchronic logic insofar as the phenomenon is observed at a given moment, without interest in the evolution over a period of time. It is assumed from the identification of the existing organizations in the city and the sensitization of their directors and associates about the research exercise, obtaining the willingness of three associations, which represent 60% of the formalized community of recyclers in the territory. The methodology used to approach the object of study is qualitative, with a phenomenological approach, seeking under inductive reasoning to unveil the representations of waste pickers about the raison d’être of the associative organization, the role of associates and the images of the future for their organizations. The data collection techniques were in-depth interviews, focus groups and participant observations, all of which were applied in the context of participatory workshops conducted with the recyclers over a period of five months, with meetings every 15 days. The results indicate that there is no construction of meaning among waste pickers about what it means to be an associate; they share the representation that they are subordinate to the legal representative. In relation to leadership, there is no hint of it being exercised; waste pickers do not take initiative in any organizational matter; their role is limited to obeying orders. The organizational vision, in turn, lacks a shared meaning for the base of associates, who are understood to be the strategic governing body of the organization.
Slum tourism: factores positivos y negativos. Aproximaciones al caso de un barrio popular en la ciudad de Medellín- Colombia/ universidad nacional de Colombia
Authors: Restrepo-Montes Jonathan Alexis , Marulanda-Valencia Flor Ángela , Perez-Ortega Giovanni
Published: August 2024

Tourism has become an important engine and source of economic development and social transformation, constituting one of the sectors with the major contributing cause to the GDP of the most visited cities and countries, so new trends increasingly emerge according to the visitor preferences. Among these are listed adventure, cultural, ecotourism, and community-based tourism. The latter, which occurs especially in urban areas, generally depressed, architecturally, culturally, or socially transformed, has an impact on its inhabitants, both positive and negative. On the one hand, it makes it possible to increase income through services and the sale of goods such as food and souvenirs, but it can also have negative effects due to the increase in leases, rents, utilities and/or the discomfort caused by noise and high visitors’ traffic. This paper aims to identify the main impacts of the development of communitybased tourism in the Comuna 13 of Medellín and describe the perception of tourists, traders, local community leaders, and residents of this neighborhood. Although tourism in this area of the city has increased exponentially, state involvement is necessary to establish controls that make tourist activity more sustainable, but it is also important to highlight the awareness on tourists’ end regarding the negative effects they can cause in the territories visited.
Sufrir en silencio: Ansiedad y depresión en estudiantes de trabajo social
Authors: Rojas-Betancur Héctor Mauricio , Hernández-Quirama Andrea , Ramírez-Prieto Laura Daniela
Published: August 2024

Studying Social Work exposes young people to the worst social scenarios of violence, poverty and marginality, added to the problems faced by university students in contemporary society, constitute two dimensions that frame the need to measure aspects of mental health. Zung scales for anxiety and depression were applied to a non-probabilistic sample of undergraduate and graduate students (n=160) and correlated with composition variables of the participant population. A low level of anxiety and a high level of depression stand out, both results are strongly associated with the level (undergraduate or postgraduate p<0.01), sex (p<0.01), health status and economic situation of the student (p<0.05 and p<0.01). It concludes a worrying level of depression, especially in younger students and a direct relationship with the study variables.
Análisis bibliométrico de la dinámica entre responsabilidad social y desempeño financiero
Authors: Acevedo-Amorocho Alejandro , Chía-Suárez María Ana-Martina , Cala-Díaz María Teresa , Restrepo-Sierra Luis Hernando
Published: August 2024

The dynamics between Corporate Social Responsibility (CSR) and Financial Performance (FD) is an issue that has taken on a relative importance in the dynamics of the business and social fabric, an appreciation that is supported by the changes of market unification and the constant transformations in the behavior of stakeholders, where not only is the achievement of returns for its shareholders relevant, but it also incorporates factors of a social and environmental nature, therefore, the objective of this work was to review the correlation observed between CSR and DF, bibliometric review developed for the time window between the years 2000 to 2021, based on a review of scientific writings housed in the Web of Science (WoS) database, where 1,188 articles were identified, decanting 219 publications for the application of the bibliometric analysis that best fit the object of study, analyzing the scientific findings by country and with dyes; the methodologies used, the topics addressed, among other variables, showing that the review of the topic covers 68.9% of the total publications, in the same way the countries with the greatest activity are the United States, China and Spain with 40% of the total publications. It is concluded that the analysis has become an important factor for the business sector and the social system, a practice that is gaining relative strength as a value proposition aligned with the objectives of sustainable development that society requires to guarantee the survival of future generations.
Producción de carbón vegetal en Cuba, propuesta de un sistema de costo basado en actividades
Authors: Rojas-Hernández Dairon , Acosta-Rodríguez Leo Alejandro , Pelegrín-Mesa Arístides
Published: August 2024

The main objective of the research addressed is the design of an activity-based cost system (ABC), through the use of the charcoal value chain designed for the Cuban case in the Agroforestal company of Pinar del Río, Cuba to the calculation of profits throughout the entire chain, through each of its defined processes. The results are based on internationally recognized theoretical references, supported by a descriptive methodology, through the analysis of documents using tools to obtain information: interviews. With the proposal, the main result is to evaluate each of the responsibilities of the managers to make decisions with the results obtained by each of the activities of the chain, to obtain the costs and income for each of its links by applying the method (ABC).
Ideological profiles of intellectuals from the modern age
Authors: Cifuentes-Medina José Eriberto , García-Sandoval Pablo Andrés , González-Moreno Mayra Fernanda
Published: August 2024

To discuss the role and possible importance that may have, to have the intellectuals in the different areas, disciplines or science that engender and cultivate knowledge for the society of the present and the future; without missing the past; in several scenarios of knowledge and knowledge of society. This research is addressed from the qualitative -Hermeneutic paradigm in the perspective of a documentary and systematic review of the literature for the object of study. In the process of understanding the intellectual as that person who is dedicated to the critical reflection of reality, according to his discipline and place of position in society, so much so that his intervention influences the reality, reaching a level of authority. In the surroundings and before public opinion, according to the field of influence of each intellectual. The fields are diverse: political, religious, literary, artistic, among other ways of reconnaissance by society and its action, it generates a way of reaching out to the public of intervention that helps to consolidate the history of the ideas.
Use of classcraft for the development of reading and writing skills in primary basic education
Authors: Goyeneche-Fernández Biviana Carolina , Monroy-Fonseca María Nelba , Niño-Vega Jorge Armando , Fernández-Morales Flavio Humberto
Published: August 2024

The article presents the impact of a gamified didactic sequence on the development of reading and writing competence of fourth-grade students in a Colombian school. The sample comprised 26 students, and a qualitative approach was used for educational action research. For reading competence, progress was observed in some operations of building relationships of implication, causation, inclusion, and exclusion at the inferential level. In the writing competition, it was observed that the combination of manual and digital writing is convenient for a greater understanding of the structure of sentences, paragraphs, and texts. It is concluded that the activities of a didactic sequence through gamified tools must be attractive and diverse. Its design must be based on previous knowledge and experiences, considering questions from reality and with information about a specific object of knowledge. Furthermore, the evaluation must motivate and promote meaningful learning, which can be achieved using interactive tools that facilitate problem-solving and error correction.
Experiências no acesso e cuidado de populações vulnerabilizadas na atenção primária: Brasil, Chile, Colômbia e Peru
Authors: Teixeira Carla Pacheco , Santos Deivisson Vianna Dantas dos , Azevedo Diana Paola Gutierrez Diaz de , Chávez Alvarez Rocío Elizabeth
Published: August 2024

Combater as desigualdades e iniquidades em saúde exige uma abordagem abrangente e colaborativa. Para tal, é necessário investir em sistemas universais de saúde, acessíveis e de qualidade, com foco na população vulnerabilizada. Políticas públicas efetivas devem ser implementadas para abordar as disparidades socioeconômicas, de gênero e étnicas, que afetam a saúde das pessoas. Nesse sentido, as Experiências Latino-americanas podem ser bem diferentes considerando a organização dos sistemas de saúde, mas que precisam ser conhecidas pensando nos desafios de desenvolvimento econômico e social no “Sul Global”. Esta obra está organizada em três partes. A primeira é composta por três capítulos iniciais que trazem perspectivas de análise para o tema da desigualdade e das iniquidades em saúde na América Latina e o Caribe, a categoria “questão social” enquanto expressão das desigualdades e política social de saúde brasileira e o tema sobre as vulnerabilidades, a determinação social e a APS. Os capítulos visam contribuir para o debate mais conceitual, como pano de fundo para o livro. A segunda parte é composta por sete capítulos que abordam experiências do território nacional, e a terceira é formada por cinco capítulos que abordam experiências internacionais nos países de Chile, Colômbia e Perú. Esperamos que esta obra se constitua como um recurso educativo para pesquisadores, profissionais de saúde, gestores e formuladores de políticas, promovendo reflexões coletivas, críticas e profundas sobre o que é e o que deveria ser a APS no contexto sociopolítico latino-americano e caribenho de hoje e como poderia contribuir para reduzir disparidades e iniquidades em saúde.
Kanser Gelişiminde ve Tedavisinde Mikrobiyotanın Rolü
Authors: Taliboğlu Seval , Kıran Fadime
Published: August 2024

Her yıl milyonlarca insanın ölümüne sebep olan kanser, kardiyovasküler hastalıklardan sonra en tehlikeli hastalık grubu olarak kabul edilmektedir. Kanser tedavisi amacıyla radyoterapi, kemoterapi ve immünoterapi gibi yöntemler yaygın olarak uygulanmaktadır. Ancak, mevcut tedavi yöntemlerinin hastada olumsuz yan etkilere neden olması ek tedavi yaklaşımlarına duyulan ihtiyacı artırmaktadır. Mikrobiyotanın insan sağlığı üzerine olan etkilerine yönelik çalışmalar son yıllarda hız kazanmıştır. Kanser-mikrobiyota ilişkisi üzerine odaklanan çalışmalar ise mikrobiyotanın kanser gelişiminde ve tedavisinde önemli bir rol oynadığına işaret etmektedir. Genetik mutasyonlar, diyet, yaş, yaşam tarzı gibi risk faktörlerin yanı sıra, konak mikrobiyota çeşitliliğinin ve dengesinin bozulması da kansere sebep olan önemli etkenler arasında kabul edilmektedir. Mikrobiyota dengesinin bozulması, Helicobacter pylori, Escherichia coli, Bacteriodes fragilis ve Fusobacterium nucleatum gibi patojenlerin artmasına ve mikrobiyota çeşitliliğinin azalmasına neden olarak onkojeneze katkıda bulunmaktadır. Bunun tam aksine, dengeli bir mikrobiyota ise farkı sinyal yolaklarını uyararak anti-kanser etki gösterebilmekte ve tedavi sürecini destekleyebilmektedir. Son yıllarda, yeni mikrobiyal biyobelirteçlerin keşfi kanser teşhisinde, mikrobiyota dengesinin iyileştirilmesi ve korunması ise kanser tedavisinde oldukça önemli bir hedef haline gelmiştir. Bu derleme kapsamında mikrobiyota-kanser ilişkisi, mikrobiyal kanser biyobelirteçleri ve mikrobiyota modülasyon odaklı tedaviler dikkate alınarak özetlenmiştir.
Czerwono-biało-czerwona Łódź
Authors: Czyżewski Andrzej
Published: August 2024

„Kto kontroluje przeszłość, kontroluje przyszłość. Kto kontroluje teraźniejszość, kontroluje przeszłość” – napisał swego czasu George Orwell. Im silniejsza, im bardziej opresyjna jest władza, tym łatwiej wprowadzać tę zasadę w życie. Co nie znaczy zarazem, że od tego rodzaju pokus wolne są rządy demokratyczne. Nawet jednak skrajnie autorytarne reżymy wiedzą, że implementowana odgórnie wizja przeszłości – szczególnie niedalekiej – nie może wisieć w próżni. Uprawiana przez nie polityka pamięci historycznej musi zatem – choćby częściowo – korespondować z autentycznymi odczuciami tych, do których jest adresowana.
W czasach PRL odpowiednio sformatowany przekaz na temat II wojny światowej miał kluczowe znaczenie w procesie uwiarygodniania nowego systemu rządów. Równocześnie wydarzenia z lat 1939–1945 były silnie obecne w pamięci biograficznej obywateli powojennej Polski i w naturalny sposób współtworzyły fundamenty rodzimej „wspólnoty wyobrażonej”.
Czerwono-biało-czerwona Łódź to zarówno opowieść o budowaniu wizerunku miasta „walki i pracy”, jak i analiza napięć między ustalanymi odgórnie wzorami interpretowania przeszłości a oddolnymi wyobrażeniami na jej temat. Waga poczynionych w pracy ustaleń wynika również z ich chwilami zaskakującej aktualności. Okazuje się bowiem, że mijają dekady, a pewne schematy narracyjne dotyczące okupacyjnych losów Łodzi – a w szerszym planie Polski – pozostają niezmienne. Warto zatem krytycznie spojrzeć na okoliczności ich powstania. Ku przestrodze.
Harmony of Healing: Exploring Ayurveda's Timeless Wisdom in Pharmacy Practices: A Review
Authors: Yadav Pratibha , Manaware Rashmi , Chauhan Ranjana , Goyal Sapna
Published: August 2024

Ayurveda, an ancient system of medicine originating from the Indian subcontinent, has gained significant attention and recognition worldwide. Ayurveda emphasizes a holistic approach to health and disease management, focusing on the balance between mind, body and spirit. Traditional Ayurvedic practices incorporate various therapeutic interventions, including herbal medicines, dietary modifications, yoga, meditation and lifestyle modifications. With growing interest in natural and alternative therapies, Ayurveda has become a subject of extensive scientific investigation and integration into modern pharmaceutical practices. This review is to provide an updated and comprehensive understanding of Ayurveda¢s role in pharmacy and its potential contributions to the field of healthcare.