bluuebunny/crossref_metadata_2025 huggingface dataset:
Advancements in the Detection and Treatment of Rare ALK Fusion Mutations in Hepatocellular Carcinoma: A Case Report and Literature Review
Authors: Yan Qiu
Published: March 2024

This case report and comprehensive literature review highlights the significance of advanced molecular diagnostic techniques, particularly next-generation sequencing (NGS), in the identification and treatment of rare ALK fusion mutations in hepatocellular carcinoma (HCC). Through a detailed analysis of a single patient case, accompanied by a review of existing literature, we underscore the diagnostic challenges and therapeutic potential associated with rare ALK fusions in HCC. Our findings demonstrate the superior capability of NGS, both DNA-based and RNA-based, in detecting these mutations, leading to targeted treatment approaches with ALK inhibitors. The case report illustrates the practical application of precision oncology in HCC, showcasing significant clinical benefit and improved treatment outcomes with the use of ALK inhibitors for rare fusion types. This study not only contributes to the existing body of knowledge by documenting a rare instance of ALK fusion in HCC but also advocates for the integration of comprehensive molecular profiling into standard clinical practice to enhance personalized treatment strategies and patient care.
Perceived Social Support as a Predictive Factor of Fatigue and Quality of Life Among Healthcare Professionals in Greece
Authors: Theofilou Paraskevi , Varemenos Ioannis
Published: March 2024

The multitude of stressful factors in the work environment, combined with work burnout and the absence of social support, significantly degrades the quality of life of health professionals. And while studies focus individually on each variable, the purpose of the present research is to classify and simultaneously correlate them, in the case of healthcare professionals in the post-pandemic era. The quantitative method with a structured questionnaire was selected to conduct the research in 506 health workers, from 14 hospitals of the 6th HealthCare Region of Greece. A fairly high level of fatigue, a low level of social support and a moderate to high level of general health were found. Physical, mental, and overall fatigue were found to be significantly negatively correlated with family, friends, significant others, and overall social support. Their correlation was found to be significantly positive in terms of general health, as well as its individual subscales. Further investigation of the cumulative effects of fatigue and the low level of quality of life of health professionals on the efficiency and level of healthcare services provided, will contribute to the formation of new approaches to dealing with and preventing the phenomenon.
Knowledge, Attitude and Practice of Emergency Contraceptive Among Female Preparatory School Students in Awsi Resu Zone(01), Afar, Ethiopia, 2023
Authors: Lemmi Ettisa Demelash , Hora Abdulhakim , Aliyi Omer , Lemi Gedemu
Published: March 2024

BACKGROUND: Students in preparatory schools are more likely to engage in risky sexual behavior, which may lead to a rise in untended pregnancies, unsafe abortions, and STIs. Many of these unplanned pregnancies can be avoided using emergency contraception. Therefore, this study was aimed at assessing the knowledge, attitude, and practice of emergency contraceptives.

OBJECTIVES: To assess the knowledge, attitude, and practice of emergency contraception among preparatory school students of Awsiresu zone (01) in Afar, Ethiopia.

Methods: A school-based cross-sectional study was conducted in selected preparatory schools in Awsi Resu Zone, Afar, Ethiopia, from October 20 to November 8, 2023, among 419 female students who were selected using the systematic random sampling method. A semi-structured questionnaire was developed and entered into the Kobo toolbox. Data were collected by five female public health officer students using interview-administered methods. A one-day discussion was held among group members and data collectors on how to obtain consent and collect complete data. The collected data was exported to SPSS window version 26 for analysis, and a descriptive analysis was performed for all variables.

RESULT: Three hundred ten (74.0%) of the students said that they have heard about emergency contraceptives. 57.7% of the students had a positive attitude towards emergency contraceptives. One hundred (32.3%) of the students said that EC is recommended as a regular contraceptive method, and another one hundred forty-one (50.2%) students said that EC can prevent STIs. Among the ten respondents who had used emergency contraceptives, six (60%) used regular contraceptives.

CONCLUSION AND RECOMMENDATIONS: The study findings showed that most of the respondents who had ever heard of emergency contraception had good knowledge and a positive attitude, despite some respondents having misunderstandings about emergency contraceptives. Therefore, the Afar Health Bureau should distribute educational materials such as brochures, posters, and flyers that teach about emergency contraception and arrange programs on a regular basis to provide accurate information concerning the utilization of emergency contraception.
Культуроориентированные стратегии и аутентичность художественного перевода (на материале перевода С. Жиенбаева произведения А. Пушкина «Сказка о золотом петушке»)
Authors: Уразаева К.Б. , Ерик Г.
Published: March 2024

Данная статья посвящена анализу переводческих стратегий – культурной решетки, доместикации, форенизации, остранения. Установление связи с аутентичностью художественного перевода потребовало анализа соотношения стратегий и их влияния на сюжет и конфликт сказки, а также передачу двоякой природы смеховой поэтики. Использование культурной решетки показано с позиций формульной поэтики народной сказки. Обосновано преобладание доместикации. Представление о доместикации уточнено как о системе примечаний и дополнений от автора перевода. К объектам доместикации отнесены образы и мотивы казахской мифопоэтики, а также приемы казахской риторической традиции. В качестве приемов доместикации анализируются фразеоресурсы казахского языка, зрелищная и звуковая символика, иронический парафраз, травестирование. Остранение уточнено как расширенный вид доместикации, обусловленный влиянием национальной концептосферы на авторскую. Остранение показано в аспекте применения поминально-обрядовой поэзии. Доминирование доместикации объясняется адаптацией оригинала к воспри-ятию адресата перевода и отражает опору Жиенбаева на приемы казахского фольклора, его символику, образный строй казахского языка. Аутентичность художественного перевода анализируется и в контексте синтагматической фа-булы и парадигматического сюжета. Показана роль комической модальности в передаче двойственной смеховой поэтики оригинала. Применение фольклорной традиции – как фактора аутентичности перевода – показано на примерах богатырской эстетики, способах повествования. Перспективность заявленной темы обусловлена изучением литературной сказки в казахской культуре.
The Effect of Hydrotherapy on Pain Intensity and Functional Ability in Lumbar Disk Herniation (LDH) Patients that Undergo Non-operative Procedure Pre-experimental Study at Medical Rehabilitation Installation of RSUP dr. Mohammad Hoesin Palembang
Authors: Rahmadhani Theresa , Fatimah Nyimas , Zullisetiana Eka Febri
Published: March 2024

The effect of hydrotherapy on pain intensity and functional ability in lumbar disk herniation (LDH) patients that undergo non-operative procedure; pre-experimental study at medical rehabilitation installation of RSUP dr. Mohammad Hoesin Palembang. Lumbar disk herniation (LDH) is the most common disease that becaused low back pain and functional disability. Some studies mentioned that hydrotherapy is an effective treatment for low back pain.Therefore, this study was conducted to determine the effect of hydrotherapy on reducing pain intensity and improvingfunctional ability in LDH patients. This study was a pre-experimental study with one group pretest-posttest design. Data was collected by direct interviews to the patients using visual analogue scale (VAS) to measure pain intensity and Modified Oswestry Low Back Pain Disability Questionnaire to assess functional ability before and after underwent hydrotherapy once a week for 4 weeks. The data then undergo Shapiro-Wilk normality test and continue with Paired t-Test or Wilcoxon test. From 30 subjects, it was found that there are effects of hydrotherapy on reducing pain intensity (p<0,001) and improving functional ability (p<0,001) in LDH patients that undergo non-operative procedure at the Medical Rehabilitation Installation of RSUP Dr. Mohammad Hoesin Palembang. There are effects of hydrotherapy on pain intensity and functional ability in LDH patients that undergo non-operative procedure.
Quantitative Antibiotic Use Profile in Typhoid
Authors: Kurniawati Hidayatul , Marianti
Published: March 2024

Background. Typhoid fever is a common health problem in developing countries. Antibiotics are used to treat typhoid fever which is caused by a bacterial infection. Selection and use of appropriate and rational antibiotic therapy can determine a success in treatment to avoid bacterial resistance and minimize drug side effects. This study aims to determine the rationality of the use of antibiotics in adult patients diagnosed with typhoid fever in the Inpatient Installation of X Hospital in Yogyakarta. Method. Non-experimental research with descriptive observational research design and retrospective data collection. The sample of this study was inpatients with a diagnosis of typhoid fever and was recorded at the X Hospital Medical Records Installation in Yogyakarta for the period January 2016 - December 2017 which was included in the inclusion criteria. Result. Data taken came from 75 medical records that were included in the inclusion criteria. Patients were dominated by female patients as many as 64% and the adult age range was 18-30 years. The single most widely used antibiotic was levofloxacin in 27 cases (36%). The use of antibiotics with the right indication was 75 patients (100%), the right type was 75 patients (100%), the exact duration of administration was 64 patients (85.33%), the right dose was 73 patients (97.33%), the right interval was 73 patients (97.33%) and the right route of administration were 75 patients (100%). Conclusion. The rationality of using antibiotics is good with accuracy> 75%.
Multispectral Imaging Method in Laparoscopy
Authors: Yang Xin
Published: March 2024

Introduction. At present, video data acquired in narrow spectral bands are widely used to improve the efficiency of diagnostics in various medical fields, laparoscopy in particular. Conventional laparoscopy uses images obtained in the white light. Images obtained in the visible range suitably depict the color and textural features of tissues. However, it is difficult for a physician to use visible images for distinguishing between lesion areas and normal tissues, largely due to their proximity in color and texture. The efficiency of lesion detection can be improved using fluorescence images, which clearly differentiate lesion areas from normal tissues. However, the use multispectral data implies the need to present the images obtained both in the white and fluorescence light to the physician. In this paper, we propose an image composition method based on visible and fluorescence images, which facilitates their analysis by physicians. A distinctive feature of the method is the use of CIEDE 2000 metric for image fusion, which takes the properties of human vision into account.

Aim. Development of a method for multispectral data visualization, which provides a physician with an image that combines white light data and a color-highlighted area of lesions.

Materials and methods. The proposed method consists of the following steps: preprocessing of images obtained in visible and fluorescence light; segmentation of the lesion area in the fluorescence images; generation of a pseudo-color image of the segmented lesion area; and fusion of the pseudo-color image with the image obtained in the white light.

Results. The proposed method forms an image that includes an image of the operation area obtained in the white light and a separated lesion area based on fluorescence information in the near infrared range. The image composite takes the properties of human vision into account. An experimental study of the method was carried out on actual laparoscopic images, involving endoscopists who were experts in subjective evaluation of video images. The method of paired comparisons was used to evaluated the presented images. The majority of experts preferred the fused image formed by the proposed method to those visualized simultaneously in the white and fluorescence light.

Conclusion. The developed method ensures generation of images with an increased diagnostic value.
Research into the Impact of Phase Shifter Failures on the Characteristics of Slotted Waveguide Array Antenna
Authors: Bibarsov M. R.
Published: March 2024

Introduction. Currently, the impact of phase shifter (PS) failures on the characteristics of phased antenna arrays, slotted waveguide array antenna (SWAA) in particular, represents a significant problem. A review of publications shows that insufficient attention has been paid to PS failures.

Aim. To investigate the characteristics of a SWAA in the event of PS failures, when their phase takes a value equal to zero instead of the required value.

Materials and methods. The methods of statistical modeling methods were used to study the impact of failures on SWA characteristics. Calculations were carried using the Mathcad 15 software package.

Results. An algorithm for statistical modeling of the impact of PS failures on SWAA characteristics is proposed. A relationship that connects the radiation pattern with the volume of the statistical sample and the number of failed PSs is given. The malfunctions of emitters from 5 to 35 out of 50 elements were studied. Changes in the following characteristics were obtained: standard deviation – from 0.064 to 0.18, radiation pattern width – from 8 to 18 %, the level of side lobes – from 13 to 59 %, radiation power – from 0.9 to 0.3.

Conclusion. The results obtained can be used in radio-electronic systems with antenna arrays at the stage of their development. Future work will address PS failures with phases being established randomly and with random values, as well as the case of PS failures where power does not pass into the emitter. Another important direction concerns compensation of distortions resulting from failures of antenna elements.
Techniques for Accelerometer Reading Processing on Railway Transport Using Wavelet Transform
Authors: Boronakhin A. M. , Bolshakova A. V. , Klionskiy D.  M. , Larionov D. Yu. , Shalymov R. V.
Published: March 2024

Introduction. Safety issues of railway transport are inevitably connected with the condition of railway tracks and railway wheels. Various defects, such as irregularities of the railway track, may lead to emergencies and incidents. Therefore, it is important to measure and calculate short and impulse irregularities. A joint analysis of vibration acceleration signals is needed in order to study the types and size of railway track irregularities.

Aim. Development of an algorithm for irregularity search based on accelerometer readings with the vertical measurement axis.

Materials and methods. The research encompassed wavelet transformation and wavelet-based signal processing including discrete-time signal processing and continuous wavelet processing. In addition, time-frequency analysis based on Fourier transform and continuous wavelet scalogram was used. These methods provide for time-frequency localization for irregularity detection and measurement.

Results. Algorithms for vibrational signal processing using the continuous and discrete-time wavelet transform are proposed. The results show that the discrete wavelet transform is effective for multiresolution and multiband analysis, and continuous wavelet transform and wavelet scalogram allows extraction of irregularities and determination of their parameters. The relative error for irregularity depth was improved by 18 %, and the absolute error for irregularity length determinations was reduced by 7 times.

Conclusion. Application of the discrete Fourier transform and Fourier spectrogram provides for fine resolution in the frequency domain. However, separation of signal components in the time-frequency domain is impeded. The continuous-time wavelet transform ensures sufficient resolution in the low-frequency domain for component localization and visualization of irregularities.
A Compensator Microelectromechanical Acceleration Transducer with a Piezoelectric Sensing Element and Optical Reading
Authors: Busurin V. I. , Korobkov K. A. , Zaw Lwin Htoo
Published: March 2024

Introduction.Modern mobile control objects require the use of highly sensitive transducers of motion parameters, e.g., acceleration, with a wide measurement range. Increased sensitivity to measured parameters can be achieved by using precision optics, e.g., based on the tunneling effect. However, operating ranges of induced movements are less than a micrometer, which creates difficulties in positioning the sensing element. In order to improve manufacturability, to extend the measurement range and to reduce errors of acceleration transducers with optical tunneling, compensation circuits with a piezoelectric actuator as an active sensor can be used.

Aim.To extend the measurement range of microelectromechanical acceleration transducers through the use of an integrated approach, including the introduction of a compensation circuit for sensor movements based on the inverse piezoelectric effect and detection of these movements by optical means.

Materials and methods.An approach to compensating sensor movements is proposed. This approach consists in using a bimorph piezoelectric plate as an inertial element. The use of optical reading of sensor sub-micrometer displacements is considered.

Results.A block scheme and a functional scheme of a compensator micro-opto-electromechanical acceleration transducer with a bimorph piezoelectric sensing element are developed. Deformations in the sensing element under the influence of accelerations (up to 100 m/s2) and compensation voltages, whose amplitude does not exceed several volts, are investigated to ensure the possibility of using the optical tunneling effect in the proposed transducer.

Conclusion.A mathematical model of the transducer was developed and studied. A 2.5-fold increase in the  measurement range was achieved. It was shown that the introduction of compensation feedback does not decrease the permissible frequency range of measured accelerations.
Geographical Tweets Based Current Affairs Prediction Using Hybrid Features
Authors: Zala Dhruvi
Published: March 2024

Twitter serves as a prominent and freely accessible social networking platform, enabling registered and authorized users to share their opinions and reviews through concise messages known as tweets. This research aims to conduct sentiment analysis on a Twitter dataset, seeking to predict and analyze current affairs based on user behaviour and opinions. The scope of current affairs encompasses a wide range of topics, including product reviews, political discourse, movie ratings, and more, expressed in both real-time streaming and offline data on the Twitter platform. During the feature extraction phase, a hybrid approach is employed, incorporating features such as acronyms, synonyms, and emoticons utilized by users in their tweets. Additionally, a hybrid dictionary is introduced, and instead of relying solely on unigrams and bigrams, a novel algorithm, n-gram, is implemented for more comprehensive analysis. This paper delves into various methodologies, specifically focusing on multiclass classification, and introduces a proposed system along with its noteworthy results. The research contributes to the understanding of user sentiments and behaviours on Twitter, offering valuable insights into diverse current affairs.
The Role of Inflation and The Performance of Rural Banks on Indonesia’s Economic Growth
Authors: Saat Tito Arfandi , Harahap Erni Febrina
Published: March 2024

The purpose of this study is to evaluate the impact of inflation and Rural Banks' (BPR) performance—that is, their assets, credit, and third-party funding—on Indonesia's economy. For the years 2014–2020, panel data regression using a fixed effect model approach is the technique employed. Secondary data from the Financial Services Authority (OJK), Central Statistics Agency (BPS), and other relevant organizations were used in this investigation. The findings indicated, in part, that the credit variable had a significant coefficient value of 0.119, the inflation variable had a significant coefficient value of -0.033, the asset variable had a significant coefficient value of -0.006, and the third party fund variable had an insignificant coefficient value of 0.064. At the same time demonstrating how the variables of assets, third-party funding credit, and inflation all influence Indonesia's economic variables at the same time. A coefficient of determination of 0.99 is attained. Then, these findings demonstrate that the variables of inflation, assets, credit, and third-party funds account for 99 percent of the variation in economic variables' growth and fall, with other factors outside the model influencing the remaining 1%.
Application of bathymetry in water bodies in urban areas of the five Brazilian regions
Authors: Pereira Júnior Antônio , Morales Gundisalvo Piratoba , Beltrão Norma Ely Santos , Pontes Altem Nascimento
Published: March 2024

The problems occurring in water bodies can be studied and researched using bathymetric data, associated or not, with geospatial technologies. The objective was to identify the application or not of this association, and the types of water bodies, in the five regions of Brazil from 2014 to 2023. The methodology employed was the combination of comparative and historical processes, using past data. The data obtained and analyzed indicated that the dichotomy between bathymetry associated with other aspects of water resources, such as turbidity, is expanding in the five Brazilian regions, especially in the northern region of the country, due to the occurrence of the largest hydrographic basin, both in extension and in water volume, which could contribute to environmental, water, and fluvial geomorphology management. However, in regions where water use is scarce due to the absence of a more expansive water network, such as the northeast region, the application of this association is still scarce. Therefore, greater employability of bathymetric data is necessary for studies and research in water bodies in both the northeast and southeast and south regions of Brazil.
Studi Deskriptif Karakteristik dan Diagnosis Keperawatan pada Pasien Stroke Berbasis SDKI (Standar Diagnosis Keperawatan Indonesia)
Authors: Khotimah Nurul Khusnul , Azhar Maria Ulfa , Musdalifah Musdalifah
Published: March 2024

Latar Belakang: Diagnosis keperawatan yang tepat dapat membantu mengatasi masalah dan penyebab yang dialami oleh pasien, namun diagnosis dari tiap pasien itu berbeda-beda tergantung dari respon tiap induvidu. Tujuan: penelitian ini untuk mengetahui karakteristik dan diagnosis keperawatan apa saja yang biasa dialami oleh pasien stoke berbasis SDKI. Metode: Penelitian ini mengambil data subjektif dari hasil laporan akhir asuhan keperawatan program profesi ners dengan gangguan sistem persyarafan di stase mata kuliah Keperawatan Medikal Bedah Program Studi Ilmu Keperawatan Fakultas Kedokteran dan Ilmu Kesehatan UIN Alauddin Makassar Hasil: diperoleh bahwa rentang usia pada pasien yang mengalami stroke paling banyak 45-54 tahun dengan jenis kelamin paling banyak perempuang, profesi IRT (ibu rumah tangga), dan jenis stroke non hemoragik. Terdapat 13 diagnosis keperawatan berbasis SDKI yang terdapat pada pasien stoke. Kesimpulan: Dalam pelaksanaannya diagnosis keperawatan yang biasa ditegakkan pada kasus stroke berjumlah 13. Saran agar dafttar diagnosis keperawatan yang sudah dikumpul berdasarkan studi kasus bisa dijakdikan dalam 1 aplikasi yang memudahkan calonn perawat dalam proses pembelajaran untuk menentukan diagnosis keperawatan
ЗАБЕЗПЕЧЕННЯ ДОБОВОЇ ЕНЕРГЕТИЧНОЇ ЦІННОСТІ РАЦІОНУ ЛЮДИНИ, ЯК ІНДИКАТОРА ПРОДОВОЛЬЧОЇ БЕЗПЕКИ ГРОМАДЯН УКРАЇНИ В УМОВАХ ВІЙСЬКОВОГО СТАНУ
Authors: Кваша С.М. , Вакуленко В.Л. , Мороз М.А.
Published: March 2024

Стаття присвячена актуальному на сьогодні питанню – проблемам харчування та раціону українців в умовах війни та їх впливу на продовольчу безпеку держави. У статті досліджуються актуальні особливості та проблеми забезпечення добової енергетичної цінності раціону українців. Спершу визначено основні індикатори продовольчої безпеки та визначено методику оцінки Індикатора 1, що є основним питанням дослідження. На основі статистичних даних державної служби статистики України проведено детальний аналіз сучасних тенденцій зміни значень показників добової енергетичної цінності раціону людини в Україні. Визначено відмінності значення показника Індексу 1 в Україні та світі, а також з’ясовано чинники, що впливають на наведені значення. Проведено оцінку основних проблем, які впливають на забезпечення добової енергетичної цінності раціону людини в Україні та визначено їх вплив на стан харчування українців в умовах військового стану. Отримані результати свідчать про наявність серйозних проблем, що мають відчутний вплив у контексті харчування українців та, відповідно, негативно позначаються на продовольчій безпеці держави в умовах повномасштабної війни.
ЕКОНОМІЧНІ ЗАСАДИ СТАЛОГО РОЗВИТКУ АГРАРНИХ ПІДПРИЄМСТВ
Authors: Родіна О.В. , Шапошнікова І.О. , Грачова А.В.
Published: March 2024

Стаття присвячена аналізу та узагальненню тенденцій досягнення цілей сталого розвитку за частиною економічних індикаторів. Військова агресія призвела до суттєвих змін в багатьох показниках сталого розвитку. Одним з факторів, що вплинув на значення цих показників, є результативність та ефективність діяльності аграрних підприємств. Результати аналізу свідчать про тенденцію до зниження стану розглянутих економічних індикаторів у контексті сталого розвитку. Негативна динаміка у досягненні стратегічних цілей і завдань сталого розвитку унеможливлює досягнення таких індикаторів на перспективу. Запропонована модель впливу результативності діяльності аграрних підприємств узагальнила основні ризики та виклики, що впливають на їх результативність і відображаються на досягненні стратегічних цілей сталого розвитку, особливо в умовах військового конфлікту.
ІНСТИТУЦІОНАЛІЗАЦІЯ ЦИФРОВИХ ТРАНСФОРМАЦІЙ ТА ЗМІНА БІЗНЕС-МОДЕЛЕЙ В КОНТЕКСТІ РОЗВИТКУ ЦИФРОВОЇ ЕКОНОМІКИ
Authors: Семенов А.Г. , Трохимець О.І. , Томарева-Патлахова В.В.
Published: March 2024

У статті здійснено аналітичний огляд трансформації бізнес-моделей під впливом цифровізації та розроблено рекомендації щодо пріоритетних напрямів інституціонального розвитку цифрової економіки. Узагальнено основні чинники, що гальмують розвиток цифровізації та цифрової трансформації економіки, та закріплюють статус України як «країни з наздоганяючою цифровізацією». Серед ключових стримуючих чинників визначено неготовність інфраструктури та інституціонального середовища до цифрової трансформації. Окреслено перехід науки і практики до концепції цифрових (платформних) бізнес-моделей, в основі таких моделей лежить створення цінності для клієнтів через використання інформаційно-комунікаційних технологій, що сприяє реалізації потенціалу для миттєвої взаємодії між учасниками економічних процесів. Визначено ключові характеристики цифрових моделей, що відіграють ключову роль у формуванні та функціонуванні цифрових платформ, сприяючи їх інтеграції в сучасну цифрову економіку та забезпечуючи гнучке взаємодію між усіма учасниками екосистеми. Запропоновано комплексний підхід до інституціонального розвитку цифрової економіки, що охоплює інтеграцію цифрових ініціатив у стратегію економічного розвитку, усунення правових та інституційних бар'єрів на шляху інновацій, оновлення політики в області конкуренції та оподаткування, реалізацію державної підтримки цифровізації, розробку ефективних стратегій для вирішення критичних питань (права власності, конфіденційність даних, міжнародні потоки даних, компетенції та розширення використання цифрових даних, інфраструктура), а також сприяння науковим дослідженням і заснування нових підприємств у сфері ІТ, що спрямовані на імпортозаміщення та зростання експорту технологічних послуг. Реалізація підходу забезпечить оптимізацію розвитку цифрової економіки в Україні, а також сприятиме максимізації користі від цифрових трансформацій. Окреслено низу напрямків інституціоналізації державної підтримки у адаптації до сучасних цифрових технологій. Запропоновано розробку уніфікованих цифрових платформ як важливого чинника у подоланні бар'єрів для масштабного адаптування цифрових технологій для широкого кола економічних агентів.
РОЛЬ ІНФОРМАЦІЙНИХ ТЕХНОЛОГІЙ У ЗАБЕЗПЕЧЕННІ ЕКОНОМІЧНОЇ БЕЗПЕКИ ПРОЄКТНО-ОРІЄНТОВАНОЇ БУДІВЕЛЬНОЇ ОРГАНІЗАЦІЇ
Authors: Фісуненко П.А. , Пісклов О.В.
Published: March 2024

У статті проаналізовано роль інформаційних технологій у забезпеченні економічної безпеки проєктно-орієнтованої будівельної організації, відображено інформаційне забезпечення контексту прийняття управлінських рішень та перелік потенційних загроз економічній безпеці будівельних організації в умовах повномасштабного воєнного вторгнення на територію України крізь призму інформаційних технологій. В рамках наукового дослідження визначено інструментарій управління економічною безпекою будівельних організації в умовах поглиблення ролі інформаційних технологій. Визначено, що в контексті економічних перетворень та трансформаційних зрушень необхідним є комплексний аналіз будівельного сектору національної економіки враховуючи інноваційність та різноплановість впливу сучасних інформаційних технологій.
Desenvolvimento de uma cartilha educativa sobre saúde dos pés
Authors: Andrade Milena , Carrasco Aline Cristina , Michalczyszyn Lais Eduarda , Lucas Wesley Tiemme , Piuco Maria Heloiza , Luz Karoline Penteado , Bim Cintia Raquel
Published: March 2024

O objetivo dessa pesquisa foi buscar referencial teórico para estudar a funcionalidade, desenvolvimento, biomecânica, distúrbios que acometem os pés adultos e pediátricos e a importância de andar descalço, para, a partir disso, construir uma cartilha educativa digital sobre a saúde dos pés. O pé humano é uma estrutura flexível, capaz de se adaptar a variações na superfície e sob carga para manter transmissão efetiva de força entre o membro inferior e o solo durante a locomoção. O desenvolvimento do arco medial longitudinal ocorre durante a infância, modificando o pé de plano para um pé normal. Alterações deste arco pode acarretar disfunções e o uso de calçados restritivos pode levar ao desenvolvimento de lesões. Andar descalço pode favorecer a saúde dos pés tanto no adulto como para a criança. Essas informações foram adaptadas para uma linguagem acessível e compuseram a formação de uma cartilha digital sobre educação em saúde para os pés.
Measurement of Adhesion of Sternal Wires to a Novel Bioactive Glass-Based Adhesive
Authors: Papini Marcello , Sidhu Varinder Pal Singh , Towler Mark
Published: March 2024

Stainless steel wires are the standard method for sternal closure because of their strength and rigidity, the simplicity of the process, and the short healing time that results from their application. Despite this, problems still exist with sternal stability due to micromotion between the two halves of the dissected and wired sternum. Recently, a novel glass-based adhesive was developed which, in cadaveric trials and in conjunction with wiring, was shown to restrict this micromotion. However, in order to avoid complications during resternotomy, the adhesive should adhere only to the bone and not the sternal wire. In this study, sternal wires were embedded in 8 mm discs manufactured from the novel glass-based adhesive and the constructs were then incubated at 37 °C for one, seven, and 30 days. The discs were manufactured in two different thicknesses: 2 and 3 mm. Wire pull-out tests were then performed on the constructs at three different strain rates (1, 0.1, and 0.01 mm/min). No statistically significant difference in pull-out force was found regardless of incubation time, loading rate, or construct thickness. The pull-out forces recorded were consistent with static friction between the wire and adhesive, rather than the adhesion between them. Scanning electron micrographs provided further proof of this. These results indicate that the novel adhesive may be suitable for sternal fixation without complicating a potential resternotomy.
Three Buddhist Distinctions of Great Consequence for Cross-Cultural Philosophy of Personal Identity
Authors: Panaioti Antoine
Published: March 2024

This paper seeks to lay down the theoretical groundwork for the emergence of holistic cross-cultural philosophical investigations of personal identity ¾ investigations that approach the theoretical, phenomenological, psychological, and practical-ethical dimensions of selfhood as indissociable. My strategy is to discuss three closely connected conceptual distinctions that the Buddhist approach to personal identity urges us to draw, and a lucid understanding of which is essential for the emergence of appropriately comprehensive and thus genuinely cosmopolitan discussions at the cross-road between Western and Buddhist philosophical traditions. The first, primary distinction is that between the “visceral sense of self” (VSS) and the “substance view of self” (SVS). This in turn gives rise to two derivative distinctions, namely between “harbouring VSS” and “believing SVS”, and between “overcoming VSS” and “rejecting SVS”. After discussing these distinctions, I consider and respond to three philosophical objections to features of Buddhist approach to selfhood that are thrown into sharper relief when attention is paid to these three distinctions. I then discuss some of the ways the foregoing may inform research in cross-cultural philosophy of personal identity. This discussion focuses on: (1) the primacy of the first-person stance in matters of personal identity; (2) the relationship between numerical identity and narrative identity; (3) interdisciplinarity in the study of selfhood; and (4) personal identity and egoism.

 
Illusion Or Delusion? A Re-Examination of Buddhist Philosophy of Personal Identity
Authors: Panaioti Antoine
Published: March 2024

In this article, I argue against the conventional view that Buddhist philosophy of personal identity regards the self as an illusion. Critically engaging the work of Miri Albahari, I defend the view that it is instead centered around the properly diagnostic claim that the overwhelming majority of human beings suffer from a delusion concerning the nature of the self. In the central section of the paper, I draw from contemporary work in philosophy of psychiatry to gain clarity on what delusions are and how they are distinct from illusions. On the narrative theory of delusions I thence develop, delusions are best understood as faulty and harm-inducing self-referential narrative constructions. Buddhist views on human beings’ confusion concerning the self, I then submit, consist of the diagnosis of a delusion in precisely this sense. At the end of the article, I argue that in addition to its intrinsic merits this interpretation has the added advantage of bringing into sharper focus the irreducibly therapeutic character of Buddhist philosophy of personal identity, and I discuss the implications of this for future cross-cultural research on the problem of selfhood.

 
Increased Proteolytic Activity of Serratia marcescens Clinical Isolate HU1848 Is Associated with Higher eepR Expression
Authors: De Anda-Mora Karla L. , Tavares-Carreón Faviola , Alvarez Carlos , Barahona Samantha , Becerril-García Miguel A. , Treviño-Rangel Rogelio J. , García-Contreras Rodolfo , Andrade Angel
Published: March 2024

Serratia marcescens is a global opportunistic pathogen. In vitro cytotoxicity of this bacterium is mainly related to metalloprotease serralysin (PrtS) activity. Proteolytic capability varies among the different isolates. Here, we characterized protease production and transcriptional regulators at 37°C of two S. marcescens isolates from bronchial expectorations, HU1848 and SmUNAM836. As a reference strain the insect pathogen S. marcescens Db10 was included. Zymography of supernatant cultures revealed a single (SmUNAM836) or double proteolytic zones (HU1848 and Db10). Mass spectrometry confirmed the identity of PrtS and the serralysin-like protease SlpB from supernatant samples. Elevated proteolytic activity and prtS expression were evidenced in the HU1848 strain through azocasein degradation and qRT-PCR, respectively. Evaluation of transcriptional regulators revealed higher eepR expression in HU1848, whereas cpxR and hexS transcriptional levels were similar between studied strains. Higher eepR expression in HU1848 was further confirmed through an in vivo transcriptional assay. Moreover, two putative CpxR binding motifs were identified within the eepR regulatory region. EMSA validated the interaction of CpxR with both motifs. The evaluation of eepR transcription in a cpxR deletion strain indicated that CpxR negatively regulates eepR. Sequence conservation suggests that regulation of eepR by CpxR is common along S. marcescens species. Overall, our data incorporates CpxR to the complex regulatory mechanisms governing eepR expression and associates the increased proteolytic activity of the HU1848 strain with higher eepR transcription. Based on the global impact of EepR in secondary metabolites production, our work contributes to understanding virulence factors variances across S. marcescens isolates.
Isolation, Identification, Antimicrobial Resistance, Genotyping, and Whole-Genome Sequencing Analysis of Salmonella Enteritidis Isolated from a Food-Poisoning Incident
Authors: Hou Zhuru , Xu Benjin , Liu Ling , Yan Rongrong , Zhang Jinjing
Published: March 2024

Salmonella enterica is a common pathogen in humans and animals that causes food poisoning and infection, threatening public health safety. We aimed to investigate the genome structure, drug resistance, virulence characteristics, and genetic relationship of a Salmonella strain isolated from patients with food poisoning. The pathogen strain 21A was collected from the feces of patients with food poisoning, and its minimum inhibitory concentration against commonly used antibiotics was determined using the strip test and Kirby-Bauer disk methods. Subsequently, WGS analysis was used to reveal the genome structural characteristics and the carrying status of resistance genes and virulence genes of strain 21A. In addition, an MLST-based minimum spanning tree and an SNP-based systematic spanning tree were constructed to investigate its genetic evolutionary characteristics. The strain 21A was identified by mass spectrometry as S. enterica, which was found to show resistance to ampicillin, piperacillin, sulbactam, levofloxacin, and ciprofloxacin. The WGS and bioinformatics analyses revealed this strain as Salmonella Enteritidis belonging to ST11, which is common in China, containing various resistance genes and significant virulence characteristics. Strain 21A was closely related to the SJTUF strains, a series strains from animal, food and clinical sources, as well as from Shanghai, China, which were located in the same evolutionary clade. According to the genetic makeup of strain 21A, the change G > A was found to be the most common variation. We have comprehensively analyzed the genomic characteristics, drug resistance phenotype, virulence phenotype, and genetic evolution relationship of S. Enteritidis strain 21A, which will contribute towards an in-depth understanding of the pathogenic mechanism of S. Enteritidis and the effective prevention and control of foodborne diseases.
Molecular and metabolic characterization of petroleum hydrocarbons degrading Bacillus cereus
Authors: Hussain Nadia , Muccee Fatima , Hammad Muhammad , Mohiuddin Farhan , Bunny Saboor Muarij , Shahab Aansa
Published: March 2024

Hydrocarbon constituents of petroleum are persistent, bioaccumulated, and bio-magnified in living tissues, transported to longer distances, and exert hazardous effects on human health and the ecosystem. Bioaugmentation with microorganisms like bacteria is an emerging approach that can mitigate the toxins from environmental sources. The present study was initiated to target the petroleum-contaminated soil of gasoline stations situated in Lahore. Petroleum degrading bacteria were isolated by serial dilution method followed by growth analysis, biochemical and molecular characterization, removal efficiency estimation, metabolites extraction, and GC-MS of the metabolites. Molecular analysis identified the bacterium as Bacillus cereus, which exhibited maximum growth at 72 hours and removed 75% petroleum. Biochemical characterization via the Remel RapID™ ONE panel system showed positive results for arginine dehydrolase (ADH), ornithine decarboxylase (ODC), lysine decarboxylase (LDC), o-nitrophenyl-β-D-galactosidase (ONPG), p-nitrophenyl-β-D-glucosidase (βGLU), p-nitrophenyl-N-acetyl-β-D-glucosaminidase (NAG), malonate (MAL), adonitol fermentation (ADON), and tryptophane utilization (IND). GC-MS-based metabolic profiling identified alcohols (methyl alcohol, o-, p- and m-cresols, catechol, and 3-methyl catechol), aldehydes (methanone, acetaldehyde, and m-tolualdehyde), carboxylic acid (methanoic acid, cis,cis-muconic acid, cyclohexane carboxylic acid and benzoic acid), conjugate bases of carboxylic acids (benzoate, cis,cis-muconate, 4-hydroxybenzoate, and pyruvate) and cycloalkane (cyclohexene). It suggested the presence of methane, methylcyclohexane, toluene, xylene, and benzene degradation pathways in B. cereus.
Analisa Level Kinerja Struktur Pada Bangunan 12 Lantai Dengan Metode Pushover
Authors: Zuher M. Hasbi , Sidiq Zairah Nabila , Nasution Ade Prayoga , Masrilayanti Masrilayanti , Sunaryati Jati
Published: March 2024

There have been many earthquakes in Indonesia, especially West Sumatra. There was a fairly large earthquake, one of which was in 2009 with a magnitude of 7.6 on the Richter scale centered in Padang Pariaman, causing damage to vulnerable structures and loss of life. Therefore, evaluating the seismic vulnerability of buildings before an earthquake occurs is an important step in preventing damage to buildings and loss of life. In this study, a pushover analysis was carried out to determine the level of structural performance. The method used is a 12-storey building where both the existing building and its detailed properties are known, modeled using the Software Structural Analysis Program (SAP2000) Version 23. From the analysis results, the structure of the 12-storey building will experience the first yield point when given the 3rd pushover load, both at in the X-direction and Y-direction and the building structure will collapse when given the 10th pushover load in the X-direction and the 8th in the Y-direction. The performance level of the 12-story building structure is included in the Damage Control (DO) category level for the X-X direction, which means the transition between Immediate Occupancy (IO) and Life Safety (LS). Meanwhile, in the Y-Y direction, the structure is included in the Immediate Occupancy (IO) category level. Thus, in this case the building is still able to withstand the burden of the earthquake that occurred, the building can also be used again when it has received the earthquake load and the risk of human casualties is relatively small.
Implementation of New Predictive Control Based Volterra Model for Fast Dynamic Systems Using Microcontrollers: Real Time Application
Authors: Hmidene Ali , Bennasr Hichem , M'Sahli Faouzi
Published: March 2024

This paper presents a new contribution in the implementation of Volterra model predictive control for fast dynamics systems. The control approaches considered results on a switch paradigm that combine an online part based on suboptimal solution and an offline part referred to an offline neural network controller. The proposed approach has an advantage in comparison with nonlinear optimization-based control schemes. A real time application on STM32 to control a boost converter is studied and the results show very remarkable performances in time computing.
Efecto del tratamiento de pinza bipolar en OVE en felis catus
Authors: Carpio Encalada Shirley Mónica , Castillo Hidalgo Edy Paúl
Published: March 2024

Introducción: en el ámbito de la clínica veterinaria, la esterilización se muestra como la cirugía de mayor frecuencia en gatas, no solo por su papel en la prevención de patologías del aparato reproductor, sino también por su contribución a la reducción del riesgo de contagio de enfermedades de transmisión sexual. En este contexto, el presente estudio se enmarca en el dinámico panorama de la medicina veterinaria, caracterizado por una revolución impulsada por avances tecnológicos. La investigación propuso la implementación de la pinza bipolar estilo bayoneta del Electrocauterio LED SPA SURTRON 160, Código 10100.30, de origen italiano. El objetivo central consistió en evaluar el impacto del tratamiento con dicha pinza bipolar en la Ovariectomía (OVE) en gatos domésticos (Felis catus). La metodología empleada abordó la comparación de dos técnicas quirúrgicas en un grupo de 30 pacientes felinos, divididos de manera homogénea. El grupo A, sometido a OVE, fue tratado mediante sutura absorbible de ácido poliglicólico, mientras que el grupo B fue sometido al mismo procedimiento, pero utilizando la pinza bipolar. Este enfoque metodológico riguroso buscó proporcionar una evaluación comprehensiva del efecto del tratamiento con la pinza bipolar en comparación con la técnica convencional de sutura absorbible. Resultados. Al trabajar con una muestra homogénea de pacientes felinos, se logró obtener un conjunto uniforme de datos. Los resultados indican que la cirugía de Ovariectomía (OVE) realizada con la pinza bipolar requiere significativamente menos tiempo en comparación con la técnica convencional de OVE, según el análisis de la prueba T de Student. En cuanto al dolor, no se observaron diferencias estadísticamente significativas entre ambas técnicas; sin embargo, se registró una menor intensidad del dolor en el grupo tratado con la pinza, según los resultados del análisis de Kruskal-Wallis. En conclusión, se infiere que la aplicación de la pinza en la OVE en gatas es recomendable, ya que no solo se traduce en una reducción significativa del tiempo quirúrgico, sino que también se muestra como una técnica confiable. Estos hallazgos respaldan la viabilidad y eficacia del uso de la pinza bipolar en este procedimiento específico, sugiriendo su consideración como una opción preferente en la práctica clínica veterinaria.
Introduction to Topology Optimization for the Design of High Voltage Insulators
Authors: Sriram Balaji , Varadaraju Harivinay , Gupta Nandini
Published: March 2024

High Voltage insulators play a vital role in power transmission systems and are subjected to combined electrical, mechanical, and thermal stress. Common design strategies for HV insulators involve semi-analytical methods and Finite Element Analyses (FEA) to arrive at designs that meet the required design and manufacturing criteria. Topology Optimization (TO) is a design strategy widely adopted to minimize the weight and volume of the design while retaining its performance. In this work, we propose a modification to the traditional TO process to maximize the combined electrical and structural performance of HV insulators. This modification incorporates electric field considerations into the T.O. process.