bluuebunny/crossref_metadata_2025 huggingface dataset:
Results of biosimilar assessing of insulin aspart preparations of Russian and foreign production using the hyperinsulinemic euglycemic clamp method and studying the use of a new ultra-fast-acting Russian biosimilar in pumps
Authors: Saverskaya E. N. , Koksharova E. O. , Noskov S. M. , Zaikin P. G. , Banko V. V. , Arefeva A.  N.
Published: February 2024

Introduction. Ultra-fast-acting insulin aspart has great potential for improving postprandial glycemia in patients with type 1 and type 2 diabetes mellitus due to its pharmacological characteristics. The development and production of biosimilars are increasing the availability of modern insulins for patients.

Aim. To evaluate the comparability of the pharmacokinetics and pharmacodynamics profiles of insulin aspart GP40311 (tested biosimilar of domestic production) and the reference drug (produced in Denmark) under conditions of a hyperinsulinemic euglycemic clamp in healthy volunteers. To evaluate the stability of a new ultrafast-acting biosimilar when used for continuous subcutaneous infusion in insulin pumps.

Materials and methods. Double-blind, randomized, crossover study assessing the pharmacokinetics, pharmacodynamics and safety of the tested biosimilar GP40311 of domestic production and the reference drug produced in Denmark, in the form of a solution for intravenous and subcutaneous administration of 100 IU/ml, the study was conducted under conditions of a hyperinsulinemic euglycemic clamp with the participation of 36 healthy volunteers. A study of the stability, dosing accuracy and tendency to catheter occlusion of a domestic drug for continuous subcutaneous infusion was carried out using several types of insulin pumps using the gravimetric method for 72 hours. Dosing accuracy was determined at the minimum and maximum bolus dose, stability was assessed by pH and quantitative insulin content aspart. The quantitative content of insulin and impurities was assessed by high-performance liquid chromatography.

Results and discission. The 90% confidence interval for the ratio of geometric mean values of the main parameters of pharmacokinetics (AUCins.0-t and Cins.max) of insulin aspart test and reference drugs corresponded to the acceptable values of 80.00– 125.00%, which indicated their biosimilarity. When assessing PD, the comparability of action parameters is shown. The safety of the study drugs is comparable. Domestic insulin aspart met the specification standards when used for continuous subcutaneous infusion according to physicochemical parameters: pH, quantitative determination of insulin aspart, impurity content. The accuracy of dosing and the absence of occlusions in systems for 72 hours when using the drug in pumps have been established.

Conclusion. The study drugs were found to be biosimilar and equally safe. Domestic insulin aspart meets specification standards and can be used in various types of pumps.
Clinical course of infant colic during treatment with mono- and multiprobiotics
Authors: Novikova V. P. , Magаmedova D. M. , Blinov A. E. , Varlamova O. N.
Published: February 2024

Introduction. Probiotics have been shown to be effective in the treatment of infant colic for Lactobacillus reuteri. In recent years, multi-strain probiotics have been used for the same purpose.

Aim. To evaluate the clinical course of infant colic during treatment with mono- and multiprobiotics and in follow-up.

Мaterial and methods. 110 children aged from 1 to 5 months (average age 3.2 ± 0.3 months) suffering from colic were examined. Patients were randomized into three groups: group 1 (n = 30), received the BioGaia Probiotic drops for baby, group 2 (n = 40) – Bac- Set Bab multiprobiotic, group 3 (n = 40) – symptomatic therapy.

Results. The average duration of crying of children who received multiprobiotic (group 2) was significantly less than that of children of the first and third groups (group 1 – 1.62 ± 0.5 hours; group 2 – 1.1 ± 0.3 hours; group 3 – 2.5 ± 0.6 hours; p < 0.001). The duration of crying during colic was in correlation with the level of zonulin in the stool (r = 0.58, p < 0.05).

Treatment with the multiprobiotic was accompanied by a decrease in the frequency of bowel movements from 4.15 times a day to 3.27 times and was not accompanied by an increase in constipation, while monostrain probiotic and symptomatic therapy did not change the frequency of daily bowel movements and did not affect pre-existing constipation.

Conclusions. The multiprobiotic turned out to be more effective than the single-strain monostrain probiotic and symptomatic therapy in the speed of relieving infant colic; it completely stops them in 87.5% of children and reduces them in 12.5%. The effect of multiprobiotic is persistent, relapse was noted in only 13.3% of children, whereas after taking monostrain probiotic the relapse rate was 33.33%. The effect of multiprobiotic is associated with its ability to normalize intestinal microbiota and reduce the permeability of the intestinal wall.
Standardization and comparative analysis of the quality of acetylsalicylic acid tablets
Authors: Ogneshchikova Natalia D. , Orlova Tamara V. , Nesterova Alla V.
Published: February 2024

Currently, the pharmaceutical industry offers a fairly large number of acetylsalicylic acid (ASA) tablets. Relevant is their high quality, regardless of the manufacturer, the stability of indicators in the process of mass production. Objective: comparative analysis of the main quality indicators of ASA tablets of domestic pharmaceutical manufacturers, improvement of the test «Dissolution». Materials and methods. ASA uncoated tablets, 500 mg, 4 series from two pharmaceutical manufacturers. Evaluation of the quality of tablets and statistical processing of the results of a chemical experiment were carried out according to the relevant methods of the State Pharmacopoeia of the Russian Federation. Results. ASA tablets were standardized according to the following indicators: description, identity, mass uniformity of dosage forms, disintegration, abrasion, quantitative determination of the active substance, dissolution, impurities (salicylic acid). The dissolution profiles of ASA were studied depending on the dissolution medium. Compliance of all samples with the requirements of regulatory documentation was established. A unified test method "Dissolution" for ASA tablets is proposed. Conclusions. The identical composition of the excipients used, the high quality and pharmaceutical equivalence of ASA tablets of different production series and manufacturers have been established.
Analysis of upper and lower nappe profiles of large orifice for the design of bottom and roof profiles of high head orifice spillway
Authors: Bhatti Shafqat Hussain , Ur Rehman Habib , Sarwar Muhammad Kaleem , Zaffar Muhammad Waqas , Zafar Muhammad Awais , Tariq Muhammad Atiq Ur Rehman
Published: February 2024

Large orifices are constructed for dams to release water and sediments from reservoirs. Such structures are called submerged spillways. Numerous studies have investigated discharge coefficient, velocity coefficient, and head loss coefficient of large orifices; however, the literature lacks data on the upper and lower nappes of the jets from these orifices. In the present experimental study, the upper and lower nappes are investigated up to 80 m head at different gate openings. The observed minor deviation between the lower nappe profile and trajectory profile equation suggests sensitivity to different factors. The significant role of the coefficient of velocity, averaging at 0.926, highlights its impact on minor deviation. Subsequently, the impact of the solid bottom profile on the discharge coefficient and upper nappe profile are also examined. The results show improvement in discharge coefficient of a sharp-edged large orifice, which increased from 0.69 to 0.74. The results also indicate that the upper nappe profiles and United States Bureau of Reclamation (USBR) profiles are similar. The improvement in the upper nappe profile indicates the significant role of the solid bottom profile, which consequently was found to be helpful in defining the roof profile of an orifice spillway. .
Disease Course and Pulmonary Involvement of COVID-19 during the Delta
Variant Period in Germany: A Comparative Study of Vaccinated and
Unvaccinated Patients at a Tertiary Hospital
Authors: Steuwe Andrea , Ljimani Alexandra , Andree Marcel , Wienemann Tobias , Lübke Nadine , Walker Andreas , Ole Jensen Björn-Erik , The Racoon Study Group  , Radke Karl Ludger , Antoch Gerald , Valentin Birte
Published: February 2024

Background:

Despite the availability of vaccines, there is an increasing number of SARS-CoV-2-breakthrough-infections.

Objective:

The aim of this study was to determine whether there is a radiological difference in lung parenchymal involvement between infected vaccinated
and unvaccinated patients. Additionally, we aimed to investigate whether vaccination has an impact on the course of illness and the need for
intensive care.

Methods:

This study includes all patients undergoing chest computed tomography (CT) or x-ray imaging in case of a proven SARS-CoV-2 infection between
September and November 2021. Anonymized CT and x-ray images were reviewed retrospectively and in consensus by two radiologists, applying
an internal severity score scheme for CT and x-ray as well as CARE and BRIXIA scores for x-ray. Radiological findings were compared to
vaccination status, comorbidities, inpatient course of the patient’s illness and the subjective onset of symptoms.

Results:

In total, 38 patients with acute SARS-CoV-2 infection underwent a CT scan, and 168 patients underwent an x-ray examination during the study
period. Of these, 32% were vaccinated in the CT group, and 45% in the x-ray group. For the latter, vaccinated patients exhibited significantly more
comorbidities (cardiovascular (p=0.002), haemato-oncological diseases (p=0.016), immunosuppression (p=0.004)), and a higher age (p<0.001).
Vaccinated groups showed significantly lower extent of lung involvement (severity scores in CT cohort and x-ray cohort both p≤0.020; ARDS
42% in unvaccinated CT cohort vs. 8% in vaccinated CT cohort). Furthermore, vaccinated patients in the CT cohort had significantly less need for
intensive care treatment (p=0.040).

Conclusion:

Our data suggest that vaccination, in the case of breakthrough infection, favours a milder course of illness concerning lung parenchymal
involvement and the need for intensive care, despite negative predictors, such as immunosuppression or other pre-existing conditions.
Electrochemical Sensing of Vitamin C Using Graphene/Poly-Thionine
Composite Film Modified Electrode
Authors: Murugan Ridhu Varshini , Magesh Vasanth , Vijayalakshmi K. , Atchudan Raji , Arya Sandeep , Sundramoorthy Ashok K.
Published: February 2024

Background:

Gastric irritation and kidney problems occur due to excess ascorbic acid
content, whereas the lack of ascorbic acid in the human body leads to poor wound healing, muscle
degeneration, and anemia.

Objectives:

Herein, we report the development of an electrochemical sensor for the detection of
ascorbic acid using poly-thionine/ graphene (P-Th/Gr) modified glassy carbon electrode (GCE) in
0.1 M phosphate buffer solution (PBS) (pH 7.4). Electrostatically fused graphene affixed with
poly-thionine was successfully illustrated for effective voltammetric sensing of ascorbic acid.

Methodology:

FE-SEM indicated the blended edge of a 2D graphene sheet with a deposited thin
layer of polymer, which confirmed the formation of a poly-thionine/graphene composite. The cyclic
voltammetry (CV) technique was utilized for the electrochemical assay of ascorbic acid (AsA,
Vitamin C).

Results:

With the increased concentrations of AsA, the oxidation peak current of ascorbic acid increased
at 0.0 V, and the overpotential showed a decrease compared to bare GCE. The effect of
scan rate on cyclic voltammograms was recorded with 500 μM of ascorbic acid from 10 mV/s to
250 mV/s, which indicated that AsA oxidation is a diffusion-controlled process on poly-thionine/
graphene-modified electrode.

Conclusion:

It was concluded that a poly-thionine/graphene composite-based sensor could be useful
for the determination of ascorbic acid in various biological samples.
Büyük Depremden 6 Ay Sonra: 2023 Türkiye Depremiyle İlgili Haberlerin ve Diğer Durumların Ergenlerde Kaygı Düzeyi ve Travma Sonrası Stres Bozukluğu Belirtileriyle İlişkisi
Authors: SARMAN Abdullah , TUNCAY Suat
Published: February 2024

Giriş: Depremler ve oluşturduğu etkiler küresel sağlık sorunlarına neden olmaktadır. Kaygı ve travma sonrası stres bozukluğu depremlerin ardından görülen en yaygın olumsuz psikolojik tepki olarak kabul edilmektedir. Bu araştırmada deprem haberlerinin ergenlerde kaygı ve travma sonrası stres bozukluğu belirtileriyle ilişkisi ve bu ilişkiye aracılık eden risk faktörlerinin belirlenmesi amaçlanmıştır.
Yöntem: Kesitsel-tanımlayıcı modeldeki bu çalışma, depremden altı ay sonra Türkiye'nin doğusunda yer alan bir bölgedeki lise öğrencileriyle yürütülmüştür. Küme örnekleme yöntemiyle yüz yüze görüşme tekniğinin kullanıldığı araştırmaya 487 ergen katılmıştır. Kaygının travma stres belirtileri üzerindeki rolünü değerlendirmek amacıyla yapısal eşitlik modeli analizi kullanılmıştır.
Bulgular: Ergenlerin kaygı ve travma sonrası stres belirtileri puanlarının orta düzeyde olduğu belirlenmiştir. Kaygının travma sonrası stres belirtilerini etkilediği, kronik veya psikiyatrik hastalığı olanların, daha önce enkaz altında kalan veya yaralanan herhangi bir yakını olanların, sürekli olarak deprem olacağı endişesi taşıyanların, depremle ilgili haber veya yayınları izleyenlerin kaygı ve travma sonrası stres puanları yüksek bulunmuştur.
Sonuç: Uygun olmayan haber içerikleri ve yayınların çocuk ve ergenleri etkileyebileceği unutulmamalıdır. Ebeveynlerin özellikle deprem sonrası haber kanalları ve sosyal medyada çocuklarının izlediği içerikleri kontrol etmesi önemlidir. Doğal afetlerden etkilenen ergenlere, özellikle kaygı ve travma sonrası stres belirtileri gibi ruhsal problemler açısından yüksek risk taşıyanlara, bireyselleştirilmiş ve uygun psikososyal müdahaleler verilmelidir.
Arrangement of Selected Government Affairs in the Implementation of Broad Autonomy in the Unitary State of the Republic of Indonesia
Authors: Yani Ahmad
Published: February 2024

Implementing government affairs with broad autonomy, especially elective government affairs can promote and develop regional potential. However, in its regulation and implementation, some problems hamper creativity and the development of regional potential. This study aims to evaluate the development and practice of elective government affairs in Indonesia, find a way to strengthen elective government affairs, and realize the widest possible autonomy in the Unitary State of the Republic of Indonesia system. The research used normative law through a statutory, conceptual, and historical approach. The results showed that first, the development of regulations governing government affairs in Indonesia is only explicitly regulated in two laws, namely Law 32/2004 and Law 23/2014. On the other hand, this study found anomalies in the regulation of elective government affairs in Law 23/2014, namely that not all selected government affairs are delegated to provinces and districts/cities even though elective affairs have very potential in developing the potential and distinctiveness of the region. Not only that, in practice, selected government affairs are sometimes hampered by the application of NSPK from the central government. Second, the strengthening of selected government affairs to implement the widest possible autonomy can be done by strengthening selected government affairs based on the NKRI system and redesigning NSPK in the implementation of selected government affairs in the regions.
Duurzaam innoveren is groen opereren
Authors: Kruijff Schelto
Published: February 2024

Terwijl we medisch technologisch steeds meer kunnen, heeft de zorgsector zich tegelijkertijd ontwikkeld tot een van de grootste maatschappelijke vervuilers. Op 19 januari vertelt Schelto Kruijff in zijn oratie hoe we in de zorg duurzaam moeten innoveren. Toen Schelto Kruijff aan zijn carrière als jonge arts begon, beloofde hij de geneeskunde naar hun beste kunnen te zullen uitoefenen en de algehele gezondheid te bevorderen. Maar de zorg is nu verantwoordelijk voor 8 % van de totale CO2-uitstoot, meer dan de vliegindustrie, en produceert jaarlijks een afvalberg van 328 miljoen kilo. Deze zorgvervuiling heeft door klimaatverandering nu juist een negatieve invloed op de volksgezondheid. ‘Ook als oncologisch chirurg, terwijl ik mijn best doe de patiënt te helpen, draag ik bij aan dit enorme maatschappelijke probleem. Dat voelt niet goed’. Planetaire geneeskunde Onze sector moet volgens Kruijff daarom meer door een bril van ‘planetaire geneeskunde’ leren kijken. Dat wil zeggen: de gezondheid van de mens en de natuurlijke systemen om ons heen. Anders gezegd; op een zieke planeet kan de mens onmogelijk gezond leven. Dus door de druk op onze planeet te verkleinen, kunnen we in een betere gezondheid leven. Green deal Vorig jaar is er in het zorgveld de ‘Green Deal’ getekend om in 2030 het CO 2 - en grondstofverbruik in 2050 tot 0% te reduceren. Dat is een grote klus en omdat we tegelijkertijd te maken hebben met uitdagingen als een gebrek aan personeel, een oplopend zorgbudget en een teruglopende efficiëntie kan dit alleen bereikt worden met ‘Duurzame zorginnovaties’. Dit zijn innovaties die met minder grondstoffen en minder menskracht, meer maatschappelijke gezondheid genereren. Het belangrijkste is daarbij om geen medische behandelingen te verrichten die weinig aan gezondheid bijdragen. Wanneer we toch tot behandeling overgaan een zal er bij gelijkwaardigheid steeds meer ook naar de footprint gekeken moeten worden, om te kunnen bepalen welke behandeling de voorkeur verdient, zegt Kruijff. Ontwerp en opmaak: LINE UP boek en media bv | Riëtte van Zwol, Mirjam Kroondijk Illustratie/foto voorkant: Maria Koijck, gebruikt met toestemming Illustraties: Alle illustraties in dit boek zijn beschermd door het auteursrecht, mits anders vermeld. Auteursfoto: Romke Rozema Uitgegeven door University of Groningen Press Broerstraat 4 9712 CP Groningen https://ugp.rug.nl/
Peningkatan Minat Wirausaha Masyarakat melalui Pembuatan Sabun Scrub Alami dari Ampas Kopi
Authors: Handayani Sri , Wiyarsi Antuni , Fitriyana Nur , Primastuti Metridewi , Priyambodo Erfan
Published: February 2024

Kegiatan pengabdian pada masyarakat (PPM) bertujuan untuk: (1) meningkatkan pengetahuan masyarakat Seyegan tentang bahan dan manfaat sabun scrub alami dari ampas kopi, (2) meningkatkan ketrampilan masyarakat dalam pemanfaatan teknologi tepat guna pembuatan sabun scrub alami dari ampas kopi, dan (3) memotivasi minat wirausaha masyarakat Seyegan. Kegiatan PPM ini bersifat pelatihan dan dilaksanakan dengan metode ceramah, diskusi dan praktik. Melalui kegiatan tersebut, peserta telah mendapat materi tentang: (1) pembuatan sabun scrub alami dari ampas kopi, (2) kandungan dan manfaat kopi untuk kesehatan kulit, (3) sabun yang aman untuk kesehatan kulit, (4) peluang wirausaha sabun kopi, dan (5) pewarna dan pewangi yang bersifat skin grade. Peserta yang telah mengikuti pelatihan ini berjumlah 11 orang yang merupakan masyarakat di daerah Padukuhan Kamal Wetan, Mangsel VII, Margomulyo, Seyegan. Evaluasi kegiatan PPM dilakukan dalam 2 tahapan, yaitu evaluasi proses melalui observasi selama kegiatan PPM dan evaluasi hasil melalui produk sabun yang dihasilkan serta isian angket kegiatan PPM. Melalui kegiatan ini, dapat disimpulkan bahwa peserta pelatihan telah memperoleh (1) manfaat tentang bahan dan sabun alami dari ampas kopi, (2) pengetahuan dan keterampilan dalam pemanfaatan teknologi tepat guna pembuatan sabun scrub alami dari ampas kopi, namun motivasi dan minat wirausaha peserta pelatihan untuk membuat sabun scrub ampas kopi masih perlu untuk ditingkatkan.
Workshop Visualisasi Data untuk Penelitian Ilmu Sosial dan Pendidikan
Authors: Wutsqa Dhoriva Urwatul , Kismiantini Kismiantini , Kusumawati Rosita , Setiawan Ezra Putranda , Isnaini Bayutama
Published: February 2024

Adanya sumber data ilmu sosial dan pendidikan di media online membuat siapapun dapat menggunakannya untuk berbagai kepentingan. Data di media online tersebut dapat diperoleh dengan berbagai cara, salah satunya dengan scraping data. Data penelitian di bidang ilmu sosial dan pendidikan yang diperoleh tersebut tidak hanya berupa data terstruktur, akan tetapi dapat berupa data tidak terstruktur. Penanganan ketidakteraturan variabel atau kurang informatifnya variabel dapat dilakukan dengan teknik wrangling data, yang membuat data siap dianalisis. Data mentah ataupun data yang telah dianalisis dapat dikomunikasikan dengan cara yang tepat. Cara atau teknik tersebut adalah teknik visualisasi data. Oleh karena itu, dilakukan kegiatan pengabdian kepada masyarakat dalam bentuk workshop visualisasi data untuk penelitian di bidang ilmu sosial dan pendidikan. Kegiatan ini diikuti oleh mahasiswa dari berbagai program studi baik diploma, sarjana, dan pascasarjana, serta Dosen di Universitas Halu Oleo. Workshop dilaksanakan secara daring selama dua hari dengan metode pemberian materi dan demo perangkat lunak R. Pelatihan ini diawali dengan teknik scraping data dan wrangling data, lalu dilanjutkan materi berbagai teknik visualisasi data terstruktur. Pada hari kedua, materi yang disampaikan adalah praktik berbagai teknik visualisasi data terstruktur, yang kemudian diikuti sesi keempat yakni pemberian materi dan demo terkait teknik visualisasi data tidak terstruktur. Berdasarkan hasil angket, pengamatan dan tanya jawab dengan peserta pelatihan, tampak bahwa peserta antusias mengikuti kegiatan workshop ini. Peserta dapat memahami konsep dan dapat menggunakan perintah-perintah scraping data, wrangling data, dan visualisasi data terstruktur dan tidak terstruktur.
Mathematical problem solving proficiency of students with musical and kinesthetic intelligence
Authors: Ismaimuza Dasa , Pathuddin Pathuddin , Adawiyah Rabiyatul
Published: February 2024

The purpose of this study was to obtain a description of the results of the analysis of mathematical problem solving for students with musical intelligence and kinesthetic intelligence. This type of research is qualitative research. The research subjects were one student with musical intelligence and one student with kinesthetic intelligence. The results of this study indicate: Students with musical intelligence have low problem-solving abilities. It can be seen from the students' ability to solve the given mathematical problems, that is, students are less thorough in obtaining information about what is known and asked, students are not able to express a plan to explain the problem solving plan they want to do. students do not write down the complete solution, students do the calculation again only in the final step. Meanwhile, students who have kinesthetic intelligence have good problem-solving skills. It can be seen from the students' ability to solve the given mathematical problems, namely students are able to express what is known and asked in the questions using their own language. students cannot express the steps to be taken in solving the problem, students write down in full what is known and asked in full, students re-examine the results of their work by looking at and recalculating the answers that have been obtained.
Efektivitas Problem Based Learning dan Problem Solving terhadap kemampuan berpikir kritis dan kemandirian belajar matematika
Authors: Chrisdiyanto Endar , Hamdi Syukrul
Published: February 2024

Penelitian ini bertujuan untuk mengetahui keefektifan pendekatan problem based learning (PBL) dan  problem solving (PS) ditinjau dari kemampuan berpikir kritis dan kemandirian belajar siswa. Penelitian ini merupakan penelitian eksperimen semu dengan desain penelitian Nonequivalent Pretest-Posttest Group Design. Populasi dalam penelitian ini siswa SMP di Gantiwarno dan sampel penelitian kelas VIIIC dan VIIID. Instrumen pengumpulan data menggunakan tes kemampuan berpikir kritis, angket kemandirian belajar siswa, dan lembar observasi keterlaksanaan pembelajaran. Validitas isi dilakukan dengan v aiken diperoleh nilai v hitung pretest sebesar 0,97 dan v hitung posttest sebesar 0,99 lebih besar dari v tabel. Estimasi reliabilitas dengan alpha croncbach diperoleh hasil estimasi nilai reliabitas pretest sebesar 0,861, posttest sebesar 0,832, dan angket sebesar 0,90. Hasil reliabilitas alpha croncbach ini 0,70 maka reliabilitas terpenuhi. Hasil penelitian dan analisis data diperoleh bahwa pendekatan PBL lebih efektif dibandingkan pendekatan PS dalam meningkatkan kemampuan berpikir kritis dan kemandirian belajar siswa SMP.
Kemampuan numerasi dan Growth Mindset siswa SMP dan Madrasah Tsanawiyah di Kabupaten Purworejo
Authors: Wijaya Ariyadi
Published: February 2024

Penelitian ini merupakan penelitian survei yang bertujuan untuk mendeskripsikan kemampuan numerasi dan tingkat growth mindset siswa SMP dan Madrasah Tsanawiyah di Kabupaten Purworejo. Penelitian dilakukan pada enam sekolah dengan total sampel sebanyak 171 siswa kelas VIII dari tiga SMP dan tiga Madrasah Tsanawiyah di Kabupaten Purworejo. Data dianalisis menggunakan estimasi parameter untuk melihat kemampuan numerasi dan tingkat growth mindset populasi serta uji korelasi untuk melihat hubungan kemampuan numerasi dan tingkat growth mindset siswa. Hasil penelitian menunjukan bahwa secara umum rata-rata skor kemampuan numerasi siswa berada dalam kategori perlu intervensi khusus dan tingkat growth mindset siswa berada dalam kategori sedang. Berdasarkan uji korelasi didapatkan hubungan antara kemampuan numerasi dan growth mindset siswa yang signifikan namun rendah.This research is survey research that aims to describe the numeracy abilities and growth mindset level of junior high school and Tsanawiyah students in Purworejo Regency. The research was conducted at six schools with a total sample of 171 class VIII students from three junior high schools and three Madrasah Tsanawiyah in Purworejo Regency. The data was analyzed using parameter estimates to see numeracy abilities and population growth mindset levels as well as correlation tests to see the relationship between numeracy abilities and students' growth mindset levels. The research results show that in general the average score of students' numeracy skills is in the category that requires special intervention and the level of students' growth mindset is in the medium category. Based on the correlation test, it was found that the relationship between numeracy ability and students' growth mindset was significant but low.
EKSPEDISI LINTAS LAUT JAWA-SULAWESI OLEH ALRI DIVISI VI PASUKAN SEBERANG TAHUN 1946-1947
Authors: Cahyani Eva Suchi Adi
Published: February 2024

AbstrakMasa Perang Kemerdekaan tahun 1945-1950 merupakan masa krusial bagi bangsa Indonesia dalam rangka mempertahankan kemerdekaannya. Angkatan Laut Republik Indonesia (ALRI) sebagai representasi kekuatan militer matra laut telah menunjukkan eksistensinya di awal perintisan kemerdekaan dengan mengadakan Ekspedisi Lintas Laut ke luar Pulau Jawa. Menggunakan metode sejarah kritis, penelitian ini melalui beberapa tahapan yakni heuristik, kritik sumber, interpretasi, dan historiografi. Hasil penelitian ini menunjukkan bahwa ALRI Divisi VI Pasukan Seberang mempunyai peran penting dalam menyebarluaskan berita kemerdekaan dan membentuk kekuatan militer di wilayah Sulawesi Selatan. Ekspedisi terbagi dalam 6 kloter keberangkatan. Perjalanan ekspedisi yang biasanya singgah dari satu pulau ke pulau lain dimanfaatkan oleh pasukan ALRI untuk menyebarkan berita kemerdekaan kepada penduduk setempat. Angkatan Laut Republik Indonesia Divisi VI Pasukan Seberang berhasil melakukan konsolidasi dengan kelaskaran di Sulawesi yakni Pasukan Harimau Indonesia hingga terbentuk kekuatan gabungan menjadi ALRI Daerah III/Barru dan Daerah I/Mandar Majene.Kata Kunci: Ekspedisi, Jawa-Sulawesi, ALRI. AbstractThe Indonesian War of Independence in 1945-1950 was a crucial period for Indonesia in order to maintain their independence. The Navy of the Republic of Indonesia or ALRI as it is called as a representation of marine military force demonstrated its pioneering nature in the period of independence by conducting Cross-Sea Expedition out of Java Island. Using the critical history method, this research went through several stages, namely heuristics, source criticism, interpretation, and historiography. The result of this study indicate that ALRI Division VI Troops of Seberang had an important role in spreading the news of independence and forming a military power in South Sulawesi. The Navy of the Republic of Indonesia troops took their time from one island to another announcing news of independence to the local people. The Navy of the Republic of Indonesia Division VI Troops of Seberang successfully joined with the paramilitary troops in Sulawesi namely Pasukan Harimau Indonesia and formed combined forces called ALRI Region III/Barru and Region I/Mandar Majene.Keywords: Expedition, Java-Sulawesi, ALRI.
FLU SPANYOL DI JAWA 1918-1920: DARI PENYEBAB, HOAX, INFLUENZA ORDONANTIE, HINGGA KEARIFAN LOKAL MASYARAKAT JAWA
Authors: Asmara Sekar Ayu
Published: February 2024

AbstrakTopik yang dikaji dalam penelitian ini adalah sejarah flu Spanyol di Jawa tahun 1918-1920 yang meliputi (1) Penyebaran flu Spanyol, (2) Hoax flu Spanyol di Jawa, (3) Influenza Ordonantie, dan (4) Kearifan lokal masyarakat Jawa. Metode yang digunakan dalam penelitian ini yaitu metode penelitian sejarah yang meliputi empat langkah, di antaranya heuristik, kritik sumber, interprestasi, dan historiografi. Hasil penelitian ini menunjukkan bahwa flu Spanyol pertama kali masuk ke Hindia Belanda melalui aktivitas ekonomi di pelabuhan internasional lalu menyebar ke Jawa dengan gejala demam tinggi, nyeri otot dan tulang, batuk, tidak nafsu makan, lemas, dan lain-lain. Adanya hoax mengenai jumlah kematian dari virus ini menambah kepanikan di kalangan masyarakat hingga akhirnya pemerintah kolonial Belanda resmi mengeluarkan Undang-Undang Influenza (Influenza Ordonantie) pada tahun 1920. Di sisi lain, masyarakat Jawa juga menghadapi wabah penyakit ini dengan menjalankan berbagai kearifan lokal yang telah diyakini secara turun temurun.Kata Kunci: Flu Spanyol, Jawa, Hoax, Influenza Ordonantie, Kearifan Lokal.
PERBANDITAN DI WILAYAH SURAKARTA PADA MASA PEMERINTAHAN KOLONIAL HINDIA BELANDA 1850-1942
Authors: Rohmawati Ema
Published: February 2024

AbstrakPerbanditan sering menjadi suatu permasalahan yang cukup kontroversial di masyarakat Indonesia dari masa lampau hingga masa sekarang. Terlebih lagi peristiwa kriminalitas tersebut cukup meresahkan masyarakat kota namun juga meresahkan masyarakat pedesaan pada masa itu. Tulisan ini akan difokuskan pada permasalahan kriminalitas perbanditan yang terjadi di sekitar wilayah Surakarta pada masa kolonial Hindia Belanda. Adapun tujuan dari tulisan ini ialah menganalisis adanya peristiwa kriminalitas, kondisi wilayah Surakarta abad ke-19 hingga abad ke-20, muncul dan berkembangnya peristiwa kriminalitas berupa perbanditan, dan upaya pencegahan serta pemberantasan peristiwa kriminalitas perbanditan tersebut. Penulisan karya ini menggunakan metode historis dengan teknik penelitian sejarah dan studi literatur atau studi pustaka. Hasil temuan riset dengan metode dan teknik penelitian tersebut yaitu berupa penjelasan mengenai bagaimana kondisi sosial-ekonomi masyarakat di cakupan wilayah Surakarta yang mengalami ketimpangan sosial-ekonomi pada masa kolonial Hindia Belanda yang pada akhirnya mengakibatkan munculnya peristiwa kriminalitas berupa pergejolakan perbanditan. Berbagai bentuk peristiwa perbanditan muncul di wilayah tersebut hingga mendorong adanya upaya berupa suatu pencegahan dan pemberantasan oleh pihak pemerintah Kolonial Hindia Belanda agar perbanditan tidak semakin meresahkan masyarakat terutama pemerintahan Kolonial Hindia Belanda. Namun, berbagai upaya tersebut tidak dapat dikatakan berhasil hingga pada akhirnya hadirlah organisasi-organisasi yang mampu menampung keresahan penduduk hingga perbanditan dapat teratasi pada masa itu.Kata kunci: Bandit, Kolonial, Surakarta, Hindia Belanda, Sarekat Islam.
PENGALIHAN TANAH PUSAKO TINGGI SELAMA PEMBANGUNAN REL KERETA DI NAGARI TALUAK IV SUKU ABAD KE-19
Authors: Pratama Fikri Surya
Published: February 2024

Tanah pusako tinggi adalah harta asal yang dimiliki dan dikelola oleh kaum di Minangkabau. Tanah ini tidak boleh diperjualbelikan dan hanya boleh digadaikan dengan alasan yang disepakati ninik mamak kaum. Pada masa pemerintahan kolonial, perubahan mulai terjadi dengan banyaknya tanah pusako tinggi yang dibeli oleh pemerintahan kolonial untuk keperluan pembangunan rel kereta api, seperti yang terjadi pada tanah pusako tinggi masyarakat Nagari Taluak IV Suku. Artikel ini bertujuan untuk menjelaskan strategi pengalihan tanah pusako tinggi oleh kolonialis Hindia Belanda di Nagari Taluak IV Suku dalam pembangunan rel kereta api Sumatera Tengah – Pantai Barat Sumatera, serta dampaknya. Penelitian ini bersifat kualitatif dengan menggunakan metode penelitian sejarah, dengan langkahnya: 1) heuristik, berupa sumber pustaka yakni laporan kolonial, arsip kolonial, foto, koran-koran lama, buku dan artikel jurnal yang membahas tema pengalihan kepemilikan tanah pusako tinggi; 2) kemudian kritik sumber; 3) interpretasi atau analisis data menggunakan metode interaktif, dimana proses selektif dan analisis data sudah dilakukan sejak pengumpulan sumber data penelitian; 4) terakhir historiografi. Hasil penelitian menunjukkan bahwa pengalihan tanah pusako tinggi oleh kolonialis Hindia Belanda dilakukan dengan jual beli dan ganti rugi. Ganti rugi terhadap tanah pusako tinggi di Nagari Taluak IV Suku ini merupakan ganti rugi dengan biaya terbesar kedua pada pembangunan proyek rel kereta api tersebut. Pengalihan tanah pusako tinggi menjadi rel kereta api membawa perubahan besar dengan masuknya ide-ide modernisasi pada masyarakat Minangkabau, mulai dari pakaian, tempat tinggal, transportasi, keragaman demografi, dan lain sebagainya. Di sisi lain, kekuatan adat masyarakat tradisional dalam kepemilikan pusako tinggi mulai melemah.Kata kunci: Strategi, Hindia Belanda, Kereta Api, Pusako Tinggi, Pantai Barat Sumatera.
Molecular Study on Y Chromosome Microdeletion in Male Infertility: A Cross-Sectional Design in Indonesian Men
Authors: Rizal Dicky Moch , Setyawati Ika , Adiningrat Arya , Widiyatmoko Agus , Supriyatiningsih S , Septiyorini Nandia
Published: February 2024

Y chromosome microdeletions (YCMs) are one kind of genetic disorder that contributes to male infertility. This study aims to determine the profile of YCMs in the infertile male population in Indonesia. This cross-sectional study was conducted by identifying YCMs testing data on 49 infertile male patients identified with azoospermia and oligoasthenoteratozoospermia (OAT) based on their sperm analysis, who visited andrology polyclinics in several hospitals in Yogyakarta Province between March 2021 to August 2022. Study participants underwent YCMs testing at the Molecular Medicine and Therapy Research Laboratory, Muhammadiyah University of Yogyakarta, Indonesia, using the Polymerase Chain Reaction (PCR) method according to the procedures established by the laboratory. Four out of 49 (8.2%) participants were identified to have YCMs with deletions in the Azoospermia Factor C (AZFc) subregion. Two participants identified with YCMs had cryptozoospermia in their sperm analysis. Hormonal examination showed variable results in 4 participants, including hypergonadotropic, hypogonadism, and normogonad. All participants in the study identified with YCMs showed a deletion in the AZFc subregion. This type of deletion is different from previous studies in Indonesia, so broad examinations of infertile male patients are required to figure out the deletion profile in a larger population of Indonesian sterile males.
THE INFLUENCE OF THE ROLE OF SAVINGS AND LOAN COOPERATIVES ON THE DEVELOPMENT OF UMKM
Authors: Hidayatullah M. Alief
Published: February 2024

This research aims to determine the role of the Minhajus Sa Adah Hakiki Sharia Cooperative in the development of cooperative members' micro, small and medium enterprises, looking at the aspect of business income before and after obtaining credit from the Minhajus Sa Adah Hakiki Sharia Cooperative and the work productivity of cooperative members. This research was analyzed using quantitative analysis methods using the t-test and the Mann-Whitney difference test. Based on the calculation results of the data analysis method with the decision rule if: Thit > Ttab at α = 0.05. So Ho is accepted and if Thit < Ttab at α = 0.05. So Ho was rejected. With the calculation results above, Thit is obtained at 4.138 > Ttab 2.018, so from this result Ho is accepted. By accepting Ho, the research results show that the work productivity of cooperative members has a role in increasing the business development of UMKM players. The significance value of member Micro, Small and Medium Enterprises turnover before and after using the credit role of the Minhajus Sa Adah Hakiki Sharia Cooperative is 0.156. With these results, it can be said that the Minhajus Sa Adah Hakiki Sharia Cooperative has an important role in increasing the turnover of UMKM
ANALISIS REALISASI PAJAK DAERAH: STUDI KASUS DI BPKPAD BANTUL PERIODE 2018 –2022
Authors: Asriana Dian , Muji Astuti Rina Mawarti , Setyawan Erwin Budi , Susianti Susianti
Published: February 2024

Penelitian ini menjelaskan tentang realisasi pajak daerah di Kabupaten Bantul dengan variabel penelitian semua pajak daerah di daerah tersebut. Dengan menggunakan explanatory research dan pendekatan kuantitatif diperoleh hasil dari sebelas pajak daerah hampir selama periode penelitian realisasinya termasuk baik karena melampaui target yang sudah ditentukan dengan capaian rata-rata sebesar 122,60 % dan hanya untuk pajak hiburan saja pada 2022 tidak mampu merealisir targetnya. Sementara capaian pajak daerah didominasi oleh tiga pajak besar yaitu BPHTB, PBB-P2 dan pajak penerangan jalan dengan rata-rata lebih 88 % dari pajak daerah. Kondisi ini sudah semestinya menjadikan BPKPAD sebagai lembaga yang mengelola keuangan, pendapatan dan aset daerah lebih memperhatikan dan mengevaluasi usaha-usaha yang dilakukan untuk memperoleh pajak-pajak daerah yang realisasinya sangat kecil. Dengan usaha-usaha tersebut, disamping tetap mempertahankan dan mengupayakan usaha capaian ketiga kelompok pajak dengan perolehan terbesar tersebut diharapkan mampu meningkatkan perolehan PAD yang akhirnya mampu mengurangi ketergantungan Pemda ke Pusat.
Vigilancia científica sobre procesos de gestión de información agroclimática
Authors: Cárdenas Solano Leidy Johanna , Contreras Pedraza Carlos Alberto
Published: February 2024

Los avances recientes en tecnologías como el Sistema de Observación de la Tierra, el Acceso Abierto, la Inteligencia Artificial, el Aprendizaje Automático, las Tecnologías de la Información y la Comunicación, las Plataformas de Computación en Nube y la Ciencia Ciudadana han ampliado enormemente el potencial del análisis de Big Data. Estas tecnologías ofrecen herramientas más inteligentes, interoperables y útiles para la toma de decisiones en agricultura, generando información valiosa. Se están realizando esfuerzos para recopilar datos geoetiquetados e información sobre la producción agrícola a diferentes escalas, aprovechando técnicas de aprendizaje automático y datos satelitales. Además, se está integrando la digitalización con varios aspectos del agroecosistema, como la fitogenética, la diversificación de cultivos, el uso eficiente de insumos, las prácticas agronómicas, la gestión de recursos relacionados con el suelo, la tierra y las cuencas hidrográficas, la estabilidad económica, la integración de la economía y el medio ambiente, y la gestión adecuada de los servicios ecosistémicos. Se espera que, mediante intervenciones tecnológicas y análisis de macrodatos, los agricultores puedan proteger sus cultivos de las fluctuaciones meteorológicas y las amenazas naturales, y se puedan sugerir cultivos adecuados durante períodos de barbecho o regeneración del suelo. Esto aumentaría la productividad y garantizaría una valoración sostenible del agroecosistema. En resumen, las investigaciones sobre el uso de información agroclimática se centran en comprender los desafíos y oportunidades relacionados con el cambio climático en la agricultura, así como en implementar prácticas agrícolas sostenibles y adaptativas. Según las investigaciones publicadas en Scopus, se ha identificado que los principales países que abordan esta temática desde un punto de vista científico son India, China, Estados Unidos, Italia, Francia, Alemania, España, Australia, Irán y Brasil. A continuación, se muestra una visión general de algunas acciones destacadas que están llevando a cabo en cada país: Cabe destacar que estos países están realizando avances significativos en la gestión de información agroclimática, pero las iniciativas y proyectos específicos pueden variar en cada caso y estar en diferentes etapas de implementación
Designing mHealth Apps to Incorporate Evidence-Based Techniques for Prolonging User Engagement
Authors: Monachelli Rebecca , Davis Sharon Watkins , Barnard Allison , Longmire Michelle , Docherty John P , Oakley-Girvan Ingrid
Published: February 2024

Maintaining user engagement with mobile health (mHealth) apps can be a challenge. Previously, we developed a conceptual model to optimize patient engagement in mHealth apps by incorporating multiple evidence-based methods, including increasing health literacy, enhancing technical competence, and improving feelings about participation in clinical trials. This viewpoint aims to report on a series of exploratory mini-experiments demonstrating the feasibility of testing our previously published engagement conceptual model. We collected data from 6 participants using an app that showed a series of educational videos and obtained additional data via questionnaires to illustrate and pilot the approach. The videos addressed 3 elements shown to relate to engagement in health care app use: increasing health literacy, enhancing technical competence, and improving positive feelings about participation in clinical trials. We measured changes in participants’ knowledge and feelings, collected feedback on the videos and content, made revisions based on this feedback, and conducted participant reassessments. The findings support the feasibility of an iterative approach to creating and refining engagement enhancements in mHealth apps. Systematically identifying the key evidence-based elements intended to be included in an app’s design and then systematically testing the implantation of each element separately until a satisfactory level of positive impact is achieved is feasible and should be incorporated into standard app design. While mHealth apps have shown promise, participants are more likely to drop out than to be retained. This viewpoint highlights the potential for mHealth researchers to test and refine mHealth apps using approaches to better engage users.
The Effectiveness of National Expanded Program on Immunization With Hepatitis A Vaccines in the Chinese Mainland: Interrupted Time-Series Analysis (Preprint)
Authors: Ming Bo-Wen , Li Li , Huang Hao-Neng , Ma Jia-Jun , Shi Chen , Xu Xiao-Han , Yang Zhou , Ou Chun-Quan
Published: February 2024

BACKGROUND

The high prevalence of hepatitis A delivered a blow to public health decades ago. The World Health Organization (WHO) set a goal to eliminate viral hepatitis including hepatitis A by 2030. In 2008, hepatitis A vaccines were integrated into the Expanded Program on Immunization (EPI) in China to alleviate the burden of hepatitis A, although the effectiveness of the EPI has not been well investigated.

OBJECTIVE

We aimed to evaluate the intervention effect at both provincial and national levels on the incidence of hepatitis A in the Chinese mainland from 2005 to 2019.

METHODS

Based on the monthly reported number of hepatitis A cases from 2005 to 2019 in each provincial-level administrative division, we adopted generalized additive models with an interrupted time-series design to estimate province-specific effects of the EPI on the incidence of hepatitis A among the target population (children aged 2-9 years) from 2005 to 2019. We then pooled province-specific effect estimates using random-effects meta-analyses. We also assessed the effect among the nontarget population and the whole population.

RESULTS

A total of 98,275 hepatitis A cases among children aged 2-9 years were reported in the Chinese mainland from 2005 to 2019, with an average annual incidence of 5.33 cases per 100,000 persons. Nationally, the EPI decreased the hepatitis A incidence by 80.77% (excess risk [ER] –80.77%, 95% CI –85.86% to –72.92%) during the study period, guarding an annual average of 28.52 (95% empirical CI [eCI] 27.37-29.00) cases per 100,000 persons among the target children against hepatitis A. Western China saw a more significant effect of the EPI on the decrease in the incidence of hepatitis A among the target children. A greater number of target children were protected from onset in Northwest and Southwest China, with an excess incidence rate of –129.72 (95% eCI –135.67 to –117.86) and –66.61 (95% eCI –67.63 to –64.22) cases per 100,000 persons on average, respectively. Intervention effects among nontarget (ER –32.88%, 95% CI –39.76% to –25.21%) and whole populations (ER –31.97%, 95% CI –39.61% to –23.37%) were relatively small.

CONCLUSIONS

The EPI has presented a lasting positive effect on the containment of hepatitis A in the target population in China. The EPI’s effect on the target children also provided a degree of indirect protection for unvaccinated individuals. The continuous surveillance of hepatitis A and the maintenance of mass vaccination should shore up the accomplishment in the decline of hepatitis A incidence to ultimately achieve the goal set by the WHO.
A semi-immersive musical serious game to stimulate cognitive functions in hospitalized older patients: a user experience study (Preprint)
Authors: Samson Laurent , Carcreff Lena , Noublanche Frédéric , Noublanche Sophie , Vermersch-Leiber Hélène , Annweiler Cédric
Published: February 2024

BACKGROUND

Reminiscence therapy through music is a psychosocial intervention with benefits for elderly patients with neurocognitive disorders. Therapies using virtual or augmented reality are efficient to ecologically assess, and eventually train, episodic memory in the elderly population. We designed a semi-immersive musical game called “A life in songs”. The game aspires to become a playful, easy-to-use and complete tool for the assessment, rehabilitation and prevention of neurocognitive decline associated with aging.

OBJECTIVE

This study aimed at assessing the user experience (UX) associated with this newly-designed game.

METHODS

Sixty inpatients of geriatric wards were included. After one or several sessions of the game guided by the therapist, the patients were asked to answer questions selected from 2 widely known UX scales (AttrakDiff and meCUE). The level of engagement of the patient throughout the experimental session was also assessed following an internally developed scale which included 5 levels (interactive, constructive, active, passive, and disengaged behaviors). UX mean scores were computed.

RESULTS

The results revealed very positive UX with mean values beyond the neutral values for every UX dimensions of both scales. The overall judgement was rated 3.92 (0.87) (on a scale of -5 to 5). Participants were mostly active (38%) and constructive (35%).

CONCLUSIONS

These findings demonstrated the very good appreciation of the game by geriatric inpatients. Participants’ and healthcare professionals’ verbal comments were strongly aligned with the quantitative results. Further studies are needed to evaluate the potential benefits on clinical factors such as neurocognitive functions, mood, depression, or quality of life.