bluuebunny/crossref_metadata_2025 huggingface dataset:
Проблема восприятия сообщений при использовании различных символов и вариантов оформления текста в Интернет-коммуникации
Authors: Рощупка Алина С.
Published: October 2023

В данной научной статье автор исследует и анализирует проблему, связанную со сложностью трактовки сообщений в онлайн-среде. В разделе «Введение» представлены основные трудности, с которыми сталкиваются пользователи, когда видят смайлики, эмодзи или специфичные знаки препинания в тексте сообщений. Также внимание уделяется значимости и ценности невербальных элементов, которые заменяются в Интернет-общении упомянутыми средствами. Автор обращается как к сфере лингвоконфликтологии, так и к известной схеме А. Мехрабиана, рассматривающей процентное соотношение тона голоса, жестов, мимики, и в самой маленькой части – слов в межличностном общении. Отмечается тенденция молодежи предпочитать использовать сообщения вместо телефонных звонков. Культурный контекст использования смайликов и эмодзи также рассматривается, и автор делает попытку объяснить высокую популярность этих структур в онлайн-коммуникации. Затронут аспект цифровой этики – как формальной, так и неформальной. Упомянуты возможные решения проблемы разночтений смайликов и эмодзи. Автор приводит результаты опроса, в котором создаёт подобие реальной переписки в Сети с использованием символа «точка», смайликов, эмодзи и просит участников описать их реакцию. Далее подробнее рассматриваются реакции дискомфорта. В разделе "Обсуждение результатов" автор указывает на самые часто встречающиеся значения символов и знаков препинания, таких как точка, восклицательный и вопросительный знаки, которые респонденты использовали в качестве комментариев. Обнаружены любопытные вторичные результаты в виде неиспользования точки респондентами в собственных комментариях. Особое внимание в статье уделяется общности в толковании, которая наблюдалась у большого количества участников опроса.
Educação Infantil e Criança Indígena
Authors: Ciríaco Klinger Teodoro , Santino Fernando Schlindwein , Silva Danielle Abreu
Published: October 2023

O artigo objetiva relatar resultados de um projeto extensionista que promoveu diálogos sobre Interculturalidade e Etnomatemática a partir de interações com professoras de crianças de 4 a 5 anos e 11 meses. A metodologia, de natureza interventiva, considera o trabalho colaborativo como ponto emergente de indicadores para atuação junto aos povos originários, em Mato Grosso do Sul (MS), no contexto de uma experiência de formação continuada na perspectiva de instrumentalizar a prática pedagógica para atuação com a linguagem matemática no atendimento à criança indígena. Realizamos estudos, reflexões, planejamentos e validação de propostas que valorizam a brincadeira indígena como forma de recriação das experiências infantis em sua leitura de mundo. Implementar ações voltadas à valorização dos saberes indígenas, em prol de uma formação que encara a diferença como peça fundamental da inclusão social, representa o fortalecimento das identidades étnicas no cenário histórico-político-social brasileiro e é tema emergente para a Educação Infantil.
Ginger’s Antiapoptotic and Antioxidant Effects on Ovaries of
Cyclophosphamide-therapied Rats
Authors: Shahidi Maryamsadat , Abazari Omid , Dayati Parisa , Haghiralsadat Bibi Fatemeh , Oroojalian Fatemeh , Reza Javad Zavar , Naghib Seyed Morteza
Published: October 2023

Background::

In the recent decade, there has been increasing interest in preventing ovarian toxicity
after chemotherapy exposure. It has been documented that ginger (Zingiber officinale) might normalize the hormonal
balance and control the menstrual cycle.

Objective::

This study has analyzed whether ginger extract protects against cyclophosphamide (CP)-induced
ovarian failure in rats.

Methods::

Rats were distributed into four groups consisting of vehicle, CP, ginger, and CP + ginger. At the end
of the treatment, all rats were killed under anesthesia to obtain ovarian tissues and blood samples for histological,
molecular, and biochemical experiments.

Results::

Our results indicated that ginger improves CP-caused histological changes in ovarian tissues and significantly
restores serum hormonal abnormalities. Ginger also showed unique antioxidant, anti-inflammatory,
and antiapoptotic properties in the ovarian tissues of CP-induced rats. Further, our findings indicated that ginger
might activate the Nrf2 and SIRT and inhibit the PI3K/AKT pathway in the ovaries of CP-treated rats. In
conclusion, ginger was found to protect against CP-caused ovarian toxicity in rats.

Conclusion::

The protective impacts of ginger may mediate, at least partly, by alleviating the oxidant state, inhibiting
pro-inflammatory conditions, and exhibiting antiapoptotic activities.
Hederagenin Induces Apoptosis of Human Hepatoma HepG2 Cells via the
Mitochondrial Pathway
Authors: Liu Zhuo , Tan Xiaoning , Peng Lian , Gao Wenhui , Zeng Puhua
Published: October 2023

Objective::

The objective of this study is to assess the antitumor effects of hederagenin
(HDG) in liver cancer (LC) cells and explore the related mechanisms.

Methods and Materials::

HepG2 cells were treated with HDG and cisplatin, respectively. The
CCK8 assay was used to detect cell activity, DAPI staining was used to detect the proportion of
living cells, TUNEL assay to detect the proportion of apoptotic cells, flow cytometry to detect
the membrane potential, fluoroscopic electron microscopy to detect microstructural changes to
the mitochondrial, and western blot analysis and high-content screening to detect apoptosisrelated
proteins.

Results::

Treatment with HDG inhibited the growth of HepG2 cells, decreased the proportion of viable
cells, increased the proportion of apoptotic cells, and significantly increased the proportion of cells in
the G1 phase. Fluorescence staining showed that HDG damaged the mitochondria of HepG2 cells and
significantly decreased the number of mitochondria. Flow cytometry showed that HDG decreased the
mitochondrial membrane potential of HepG2 cells. Observations by electron microscopy showed that
HDG caused swelling and vacuole formation of the mitochondria of HepG2 cells. HDG significantly
reduced the average fluorescence intensity of Bcl-2 in HepG2 cells and significantly increased that of
the pro-apoptosis proteins Bax, Cytochrome-c, and Caspase-3.

Conclusion::

HDG induced apoptosis of HepG2 cells via the mitochondrial pathway.
Expression of Transcriptional Factors of T Helper Differentiation
(T-bet, GATA-3, RORγt, and FOXP3), MIF Receptors (CD44, CD74,
CXCR2, 4, 7), and Th1, Th2, and Th17 Cytokines in PBMC from
Control Subjects and Rheumatoid Arthritis Patients
Authors: Zerpa-Hernández Darbi Alfredo , García-Chagollán Mariel , Sánchez-Zuno Gabriela Athziri , García-Arellano Samuel , Hernández-Bello Jorge , Hernández-Palma Luis Alexis , Cerpa-Cruz Sergio , Martinez-Bonilla Gloria , Nicoletti Ferdinando , Muñoz-Valle José Francisco
Published: October 2023

Introduction:

The macrophage migration inhibitory factor (MIF) plays a
pivotal role in the development of rheumatoid arthritis (RA). Previous research
indicates that MIF can trigger the expression of cytokine profiles associated with Th1,
Th2, and Th17 responses in peripheral blood mononuclear cells (PBMC) from both RA
patients and control subjects (CS). Despite these, few studies to date precisely
elucidate the molecular mechanisms involved. The present study aimed to associate
the expression of Th differentiation TF (T-bet, GATA-3, RORγt) with MIF receptors
(CD44, CD74, CXCR2, 4, 7) and Th1, Th2, and Th17 cytokines in PBMC from CS and
RA patients.

Method:

PBMC from both groups was cultured for 24 h. The expression of the
canonical and non-canonical MIF receptors and the TF was determined by flow
cytometry. Additionally, multiplex bead analysis was employed to assess the levels of
cytokines in the culture supernatants. The findings revealed that T CD4+ lymphocytes
in the CS group exhibited a heightened expression of CD74 (p<.05), whereas RA
patients displayed an elevated expression of CXCR7 (p<.001). Furthermore, T CD4+
lymphocytes from RA patients exhibited greater expression of GATA3, RORγt, and
FOXP3, along with elevated levels of pro-inflammatory cytokines compared to the CS
group (p<.001).

Result:

These results indicate that CD74 is more prominently expressed in PBMC
from the CS group, whereas CXCR7 is more expressed in PBMC from RA patients.

Conclusion:

We also noted an increased secretion of Th17 profile cytokines in RA,
potentially influenced by the activation of FOXP3 via CD74 and RORγt through CXCR7
using the endocytic pathway.
Kukoamine A Activates Akt/GSK-3β Pathway to Repress Oxidative Stress and Inflammation to Alleviate Myocardial Ischemia-reperfusion Injury
Authors: Hong Jianmao , Ye Yanqiong , Zheng Dingwen , Qian Ximing
Published: October 2023

Background:

Myocardial ischemia-reperfusion injury (MI/RI) is a serious complication
after revascularization of myocardial infarction, which causes myocardium damage. Kukoamine A
(KuA) can repress oxidative stress and neuronal apoptosis in cerebral ischemia animal models.

Objective:

In the present study, our objective was to explore the role of KuA in MI/RI and the underlying
mechanism of KuA in oxidative stress and inflammation of MI/RI.

Methods:

H9c2 cells’ cytotoxicity was detected using the lactate dehydrogenase (LDH) assay kit.
ROS level was measured by immunofluorescence. Male C57BL/6 mice were used to establish MI/RI
mice by ligating the left anterior descending coronary artery (LAD).

Results:

KuA treatment decreased the apoptosis and the cytotoxicity, increased the viability, and
reduced the activities of myocardial infarction markers (CKMB, MYO, and cTnI) in hypoxia/
reoxygenation (H/R)-induced H9c2 cells. KuA reduced the levels of ROS, MDA, and inflammatory
factors (IL-6, IL-1β, and TNF-α), and facilitated MMP and SOD levels in H/R-induced H9c2
cells. Besides, KuA activated Akt/GSK-3β axis, which was repressed by PI3K inhibitor LY294002.
Moreover, KuA improved survival times, decreased the infarct size of mice, and recovered cardiac
function in MI/RI mice. Finally, KuA alleviated MI/RI through Akt/GSK-3β pathway in vivo.

Conclusion:

Thus, KuA exerts a protective function in MI/RI through the Akt/GSK-3β axis to repress
oxidative stress and inflammation.
Narrative Testimony and Characteristics of Rottlerin for the Treatment of
Various Kinds of Cancer
Authors: Mishra Lopamudra , Kumari Lakshmi , Patel Preeti , Singh Amrita , Das Kurmi Balak
Published: October 2023

From ancient times until now, scientists have focused on herbal medicaments for treating
various diseases. Rottlerin, a potent PKCδ inhibitor, is one of the greatest herbal medications. Over
the years, it was identified that rottlerin has several cellular and molecular targets that could be involved
in the fight against cancer. The past and present research has clearly shown that rottlerin inhibits
the transcription factors, enzymes, and signaling molecules that regulate the death and life of
cancer cells. Although the anticancer property of rottlerin has primarily been attributed to the induction
of autophagy and apoptosis, current research has revealed the existence of different damage
pathways. The major part described in this mini-review is the antitumor/anticancer effects of rottlerin
in various organs of the human body affected by breast cancer, pancreatic cell cancer, bladder cancer,
NSCLC, prostate cancer, ovarian cancer, nasopharyngeal cancer, etc.
Targeted Treatment of Lung Cancer using Nanomaterials: Prospective
and Advances
Authors: Kumar Gupta Swati Sanjay
Published: October 2023

Background:

Lung cancer is the second most lethal type of cancer, with a poor survival
rate of 5 years. It is one of those malignant tumors that has grown most rapidly in the context of mortality
and morbidity.

Aim:

This review article aims to provide insight into current nanotechnological approaches taken into
consideration that provide advantages over conventional chemotherapy.

Result and Discussion:

After comparing conventional chemotherapy and nanotechnology-based
therapies for lung cancer, the results showed that recent advances in nanomaterials proved to be more
effective in lung cancer diagnosis, mitigation and treatment. Here, Surface-engineered smart nanocarrier-
based inhalations, Bio-nanocarriers for lung cancer, gas plasma nanoparticles, and magnetic nanoparticles
are discussed.

Conclusion:

After summarizing these nanomaterials, investigators concluded that the in-vivo and invitro
effectiveness of recently developed nanoparticles was found to be better than that of conventional
nanoparticles.
Generating Retinas through Guided Pluripotent Stem Cell Differentiation
and Direct Somatic Cell Reprogramming
Authors: Zhang Ke , Cai Wenwen , Hu Leyi , Chen Shuyi
Published: October 2023

:

Retinal degeneration diseases affect millions of people worldwide but are among the
most difficult eye diseases to cure. Studying the mechanisms and developing new therapies for these
blinding diseases requires researchers to have access to many retinal cells. In recent years
there has been substantial advances in the field of biotechnology in generating retinal cells and
even tissues in vitro, either through programmed sequential stem cell differentiation or direct somatic
cell lineage reprogramming. The resemblance of these in vitro-generated retinal cells to native
cells has been increasingly utilized by researchers. With the help of these in vitro retinal models,
we now have a better understanding of human retinas and retinal diseases. Furthermore, these
in vitro-generated retinal cells can be used as donor cells which solves a major hurdle in the development
of cell replacement therapy for retinal degeneration diseases, while providing a promising
option for patients suffering from these diseases. In this review, we summarize the development
of pluripotent stem cell-to-retinal cell differentiation methods, the recent advances in generating
retinal cells through direct somatic cell reprogramming, and the translational applications of retinal
cells generated in vitro. Finally, we discuss the limitations of the current protocols and possible
future directions for improvement.
iPSI(2L)-EDL: a Two-layer Predictor for Identifying Promoters and their
Types based on Ensemble Deep Learning
Authors: Xiao Xuan , Hu Zaihao , Luo ZhenTao , Xu Zhaochun
Published: October 2023

Promoters are DNA fragments located near the transcription initiation site, they can be divided
into strong promoter type and weak promoter type according to transcriptional activation and
expression level. Identifying promoters and their strengths in DNA sequences is essential for understanding
gene expression regulation. Therefore, it is crucial to further improve predictive quality of
predictors for real-world application requirements. Here, we constructed the latest training dataset
based on the RegalonDB website, where all the promoters in this dataset have been experimentally
validated, and their sequence similarity is less than 85%. We used one-hot and nucleotide chemical
property and density (NCPD) to represent DNA sequence samples. Additionally, we proposed an ensemble
deep learning framework containing a multi-head attention module, long short-term memory
present, and a convolutional neural network module.

:

The results showed that iPSI(2L)-EDL outperformed other existing methods for both promoter prediction
and identification of strong promoter type and weak promoter type, the AUC and MCC for
the iPSI(2L)-EDL in identifying promoter were improved by 2.23% and 2.96% compared to that of
PseDNC-DL on independent testing data, respectively, while the AUC and MCC for the iPSI(2L)-
EDL were increased by 3.74% and 5.86% in predicting promoter strength type, respectively. The results
of ablation experiments indicate that CNN plays a crucial role in recognizing promoters, the importance
of different input positions and long-range dependency relationships among features are
helpful for recognizing promoters.

:

Furthermore, to make it easier for most experimental scientists to get the results they need, a userfriendly
web server has been established and can be accessed at http://47.94.248.117/IPSW(2L)-EDL.
Role of Astrogliosis in the Pathogenesis of Parkinson’s Disease: Insights
into Astrocytic Nrf2 Pathway as a Potential Therapeutic Target
Authors: Bhushan Bharat , Singh Niraj Kumar
Published: October 2023

Recently, Parkinson’s disease (PD) has become a remarkable burden on families and society
with an acceleration of population aging having several pathological hallmarks such as dopaminergic
neuronal loss of the substantia nigra pars compacta, α-synucleinopathy, neuroinflammation,
autophagy, last but not the least astrogliosis. Astrocyte, star-shaped glial cells perform notable
physiological functions in the brain through several molecular and cellular mechanisms including
nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway. It has been well established that
the downregulation of the astrocytic Nrf2 signaling pathway plays a crucial role in the pathogenesis
of PD because it is a master regulator of cellular defense mechanism along with a regulator of numerous
detoxifying and antioxidant enzymes gene expression. Fascinatingly, upregulation of the astrocytic
Nrf2 signaling pathway attenuates the degeneration of nigrostriatal neurons, restores neuronal
proliferation, rejuvenates astrocytic functions, and exhibits neuroprotective effects via numerous
cellular and molecular mechanisms in the PD-like brain of the experimental animal. Here, we
discuss the numerous in-vitro and in-vivo studies that evaluate the neuroprotective potential of the
astrocytic Nrf2 signaling pathway against experimentally-induced PD-like manifestation. In conclusion,
based on available preclinical reports, it can be assumed that the astrocytic Nrf2 signaling
pathway could be an alternative target in the drug discovery process for the prevention, management,
and treatment of PD.
Protective Effect of Green Chiretta (Andrographis paniculata) against
Methotrexate-induced Cardio and Spleen Toxicity: In-vitro and In-vivo
Authors: Parthasarathy Manisha , Seenivasan Vijayadharshini , Nithiyanandam Sangeetha , Katturajan Ramkumar , Haraganahalli Bhasakarmurthy Deepak , Ganesan Raja , Valsala Gopalakrishnan Abilash , Ahmad Sheikh F. , Evan Prince Sabina
Published: October 2023

Background::

Methotrexate (MTX) is a widely used medication for treating various conditions,
including skin infections, inflammatory diseases, autoimmune disorders, and malignancies.
However, prolonged and extreme use of MTX can lead to detrimental effects on multiple organs.
Green Chiretta (GC) is a traditional medicinal plant known for its anti-inflammatory, antioxidant,
and immunostimulatory properties.

Objective::

The objective of this study is to examine the antioxidant potential of GC through in-vitro
analysis and to assess the potential protective effects of aqueous leaf extracts of GC against MTXinduced
cardiac and spleen toxicity.

Methods::

In-vitro antioxidant activity was assessed by measuring total phenolic content, DPPH,
catalase and peroxidase activity. We divided rats into five groups (n=6), and after the study, rats
were euthanized and the levels of antioxidants (SOD, CAT & GSH) and lipid peroxidase (MDA), as
well as histopathology modification of the heart and spleen tissues were examined.

Results::

Our study's findings highlight the superiority of the aqueous GC extract's antioxidant capacity
relative to other solvents (ethanol and methanol). Moreover, the aqueous GC extract's administration
to rats yielded significant progress in antioxidant levels (Superoxide dismutase, catalase, glutathione),
a reduction in lipid peroxidation (MDA), and the restoration of cardiac and spleen histoarchitecture
against MTX-induced toxicity. These results collectively emphasize the extract's potential
as a valuable therapeutic option against oxidative stress and tissue damage.

Conclusion::

The present study revealed that the aqueous GC extract demonstrated its protective
efficacy against MTX-induced cardio and spleen toxicity in Wistar albino rats
Multi-objective Reactive Power Optimization of a Distribution Network
based on Improved Quantum-behaved Particle Swarm Optimization
Authors: Song Weifeng , Ma Gang , Zhao Yuxuan , Li Weikang , Meng Yuxiang
Published: October 2023

Background:

Reactive power optimization (RPO) is crucial for distribution networks
in the context of large-scale renewable distributed generation (RDG) access.

Objective:

To address the problems caused by the connection of RDG, an RPO model and an improved
quantum-behaved particle swarm optimization (IQPSO) algorithm are proposed.

Method:

In this study, a dynamic S-type function is proposed as the objective function of the
minimum active power loss, whereas an exponential function is proposed as the objective function
of the minimum voltage deviation to establish an RPO objective function. The operating cost of
distribution is considered as the third objective function. To address the RPO problem, a QPSO
algorithm based on the ε-greedy strategy is proposed in this paper. ModifiedIEEE33 bus and
IEEE69 bus systems were used to evaluate the proposed RPO method in simulations.

Results:

The simulation results reveal that the IQPSO algorithm obtains a better solution, and the
proposed RPO model can considerably reduce active power loss, node voltage deviation, and distribution
network operating costs.

Conclusion:

The RPO model and IQPSO algorithm proposed in this study provide a highperformance
method to analyze and optimize reactive power management in distribution network.
A comparative clinical study for haemostatic action of Lajjalu Lepa and Darvi Lepa in Raktarsha
Authors: Pankaj Kumar Yadav  , Ankita Chitragupt
Published: October 2023

Arsha is a disease afflicting mankind for thousands of years. In Ayurvedic literature, this disease is mentioned as one of the ‘Ashtamahagadas’[1] and difficult to cure. Nearly 45% of patients attending ano-rectal clinics suffer from the symptoms of Arsha. Vitiation of Doshas adversely affects the digestive fire resulting in Mandagni which in turn lead to constipation. Prolonged contacts of accumulated Mala or excretory material taint Gudavali resulting in Arshas.[2] Acharya Charaka explains Arsha as an abnormal fleshy growth at anorectal region whereas at other sites it is called as Adhimamsa.[3] In spite of progress in modern medicine, there is very little scope in terms of treatment of Hemorrhoids, Surgical techniques of performing hemorrhoidectomy are many and their complications such as pain, anal incontinence, stricture etc. are well known. All these modern surgical & Para surgical techniques are associated with post-operative complications which may be early complications such as hemorrhage, secondary infection etc., & late complications such as anal stricture. Anal incontinence, profuse watery discharge etc.,[4] Hence, in the present study a special emphasis will be made by selecting noninvasive, effective and economic therapeutic modality which has been explained with great details in ancient Ayurvedic Samhitas for the management of Arsha with different type of Lepa which is a painless simple procedure.
Assessment of Rasavaha Srotasa
Authors: Abhishek Dhadhich  , Pallavi Choudhary  , Rakesh Kumar Sharma  , Navneet Dadhich
Published: October 2023

Human body is mainly composed of three types of substances viz. Dosha, Dhatu and Mala. Although all these entities are present in body itself, but some kind of transportation system is required to carry these substances from the site of production to the site of action. For transportation mode of such body constituents, the special term 'Srotasa' is used which denotes a channel through which substances flow from one part to another part of body. Srotasa is a structural and functional unit of the body which comprises of two openings. From one opening it starts or begins the functioning and at the other opening it concludes it. Hence, for a Srotasa the two openings are connected to the body organs which are described as Srotomoola or Moola Sthana (root of Srotasa).
Sushruta’s concept of Seevana Karma - A Review Article
Authors: Harsha M. Kencharadder  , Siddayya Aradhyamath  , Adithya JV
Published: October 2023

Ayurveda is eternal science and considered by many scholars to be the oldest healing science. Ayurveda consists of Ashtangas (8 branches of ayurveda) and Shalyatantra is one and foremost among them. Acharya Sushruta is considered as pioneer of Shalyatantra and contribution of Acharya Sushruta to Shalyatantra are innumerable. Ashtavidha Shastra Karma is unique contribution of Acharya Sushruta. Ashtavidha Shastra Karma includes Chedana, Bhedana, Lekhana, Eshana, Aharana, Vedhana, Visravana, Seevana.[1] These eight specific surgical procedures are useful in the management of all the diseases which require surgical intervention. In the present scenario though modern surgery has developed a lot but the basic concepts remain the same and they are base for these developments. Seevana is one among Ashtavidha Shastrakarma. Acharya Sushruta has emphasised clearly on Seevana Karma like its indication, contraindication, materials and the procedure. Suturing is the term used in Modern science for Seevana. A suture is any thread which brings into opposition two surfaces or tissues.[2] Suturing is a stich or series of stiches made to secure opposition of the edges of a surgical or traumatic wound. No surgery is complete without suturing. A lot of scope in developing suturing material told by Acharya Sushruta are on lines of modern medical science. Hence in this regard a small attempt has been made to through light on Seevana Karma and Suturing. This article summarises concept of Seevana Karma according to Acharya Sushruta.
An overview of Srotas w.s.r. to therapeutics in Ayurveda
Authors: Nitish Sharma  , Pawan Kumar Kirar  , Lajwanti Keswani  , Salil Jain  , Monika Parihar
Published: October 2023

In Ayurveda, Ayu is defined as conjunction of body, soul, mind and senses. Each has been given due importance in the maintenance of health and prevention and cure of disease. Ayurveda mention various aspects related to the normal physiological functioning of body, diseases and their management. Ayurveda elaborated one such concept of Srotas which means microchannels of body that performs functions of transportation and circulation. The Srotas not only perform important functions of body but also restore normal health status of body. Vitiation and depletion in Srotas can lead many pathological events inside the body. Present article described clinical perspective of Srotas as per Ayurveda considerations. When the vitiation of Srotas occurs, the treatment of Moolasthan can cure the whole deformity because Moolasthan is the control system of the whole Srotas.
Ayurvedic concept of Ahara Rasa and Rasa Dhatu
Authors: Himanshu Sahu  , Arun Kumar Kalihari  , Gitanjali Sasmal  , Vinay Bhardwaj
Published: October 2023

According to Ayurveda, food is the main pillar of healthy life. Living body is continuously subjected to wear and tear process. Dhatus which are being lost in physiological activities are replenished by food and water. Man needs to eat food to build a new Dhatus and to repair damage Dhatus. After consumption food is digested in gastro intestinal tract. Fluid formed from the digested part of food is called as Ahara-Rasa. For growth, Dhatus needs nourishment, and these Dhatus are nourished by food and water. Aahar Rasa is formed in Annavaha Srotas. Aahar Rasa contains nutrients of seven Dhatus. Aahar Rasa is absorbed from Grahani (small intestine) and brought into heart. Heart is a root of Rasavaha Srotas, hence in heart, Rasa Dhatvagni transforms nutrients of Ahara Rasa into stable Rasa Dhatu. Rasa Dhatu is formed in Rasavaha Srotas. Rasa is the first Dhatu formed from Aahar-Rasa.
Ayurvedic management of Gridhrasi with special reference to Sciatica: A Case Study
Authors: Shashidhar SH  , AS Prashanth
Published: October 2023

Background: About 70% to 80% of people in India report having low back pain, making it one of the most prevalent complaints. The most frequent intervertebral disc prolapse among the many causes of low back pain is referred to leg, buttock, or hip which frequently outlines the characteristics of Sciatica syndrome. Sciatica is similar to Gridhrasi, one of the most prevalent Vata illnesses, according to Ayurveda. Aims & Objectives: The purpose of this study was to evaluate the effectiveness of Ayurvedic treatment in Gridhrasi. Materials and Methods: Single case study of a 44-year-old married man who had been visiting an Ayurvedic hospital for Ghridrasi of the right leg for eight months had previously been diagnosed with a diffuse bulging of the L4-L5 intervertebral disc. He had one month of Panchakarma therapy, which included Abhyanaga Swedana, Patra Pinda Swedana, and Tila Pinda Swedana in combination with Shamana Chikitsa. Results: After a month, the patient's symptoms were assessed, and the outcomes were good. The patient's general quality of life had also greatly improved. Conclusion: The mentioned treatment reduces Gridhrasi symptoms significantly.
Ayurvedic management of Urdhwaga Amlapitta (Dyspepsia): A Case Report
Authors: Shubhangini S. Kolar  , Shivaleela S. Kalyani  , Sunilkumar M. Chabanur
Published: October 2023

Due to various factors in progressive civilization of present day speedy environmental changes, adaptation of new food materials, change in method of cooking, atmospheric Pollution, encroachment of various chemical agents in newer lifestyle, occupational hazards have precipitated the trend of emerging diseases. Along with those tremendous stress and anxiety have significantly aggravated the diseases like Amlapitta, a GI tract disorder. It is associated with the causative factors like faulty dietary habits, sedentary life style & stress, Preserved foods, curd, excessive alcohol, caffeine, spicy, fast, junk foods & lack of exercise etc. A single clinical case trial with pre-test, follow-up, and post assessment was done on drug Narayan Ghrita, mentioned in Bhaisajya Ratnavali Amlapitta Chikitsa Adhikara was advised twice daily, before food for 15 days along with life style modifications like Ahara, Vihara, Achara was advised. By the present study it can be concluded that Narayan Ghrita and life style modifications helps in controlling and is effective remedy for Urdhwaga Amlapitta.
Pemphigus Vulgaris - A pragmatic approach through Panchakarma
Authors: Preeti Chaturvedi  , Nupur Namdeo
Published: October 2023

Blistering disorders are a group of diseases presenting with vesicles and bullae over skin and mucous membrane.[1] Pemphigus describes a group of chronic bullous eruptions of the skin, where Pemphigus vulgaris is the commonest one.[2] Which is a life threatening autoimmune mucocutaneous blistering disease with a mortality rate of 5-15%. In Ayurveda all the skin disorders are collectively named under the heading of Kushta. Ayurveda Acharyas have described all the Kushta are having the involvement of all the three Dosha’s. But the signs, symptoms and the treatment depend on the predominance of the Dosha involved. Visphotaka and Agnivisarpa can be compared to Pemphigus vulgaris due to its resemblance in signs and symptoms. This disease needs early and proper treatment to prevent further morbidity or mortality. To control these diseases, generally physicians use corticosteroids and immunosuppressive drugs as adjuvants. Here, an attempt is made to study in detail about the disease Pemphigus vulgaris and its understanding through Ayurveda. Management of such diseases through Ayurveda is rarely reported. A case report of 32yr old male patient presenting with the similar complaints treated with Vamana followed by Virechana Karma along with Shaman drugs is presented in this paper.
Multifacet approach towards Pakshaghata - A Successive Case Study
Authors: Rachana P. Badaji  , Abdul Khader
Published: October 2023

Pakshaghata is one among the 80 Vataja Nanatmaja Vikaras. It is a condition which one half of the body is affected leading to the Ruja, Vaksthamba, Karmahani etc. Prognosis depends on many factors including Vaya, Bala, Dosha involvement etc. In contemporary science it can be correlated to the Cerebrovascular disease. Methodology: A 58 Years old Female Patient who is known case of RA since 20 years and HTN since 2 years under medication approached to OPD of SKAMCH & RC Bangalore in a stretcher, with a Lakshana of reduced strength in right half of the body, pain, loss of function, sensation, slurred speech and was unable to walk. Based on the clinical presentation and Ayurvedic parameters, the condition was diagnosed as Pakshaghata with special reference to the Haemorrhagic Stroke with Hemorrhage in Sub cortical Region Involving MCA and Chikitsa was adopted keeping in the Dhatukshayajanya pathology as a base. Sarvanga Abhyanga, Sarvanga Nadi Sweda and Rajayapana Yoga Basti and Physiotherapy was adopted as a treatment modality. Shamanoushadi like Brihatavatachintamani Rasa, Nityananda Rasa, Arogyavardhinirasa Capsule, Palsineuron, Dhanvantarum Kashaya, Mahamanjishtadi Kashaya and Sahacharadi Kashaya were prescribed. Result: After 1 month of treatment and follow up, there were drastic improvements in the sign and symptoms. Assessment done on the SS-QoL Scale and Barthes index for stroke shown significant result. Discussion: This article is a discussion about a case of Hemorrhagic Stroke of Brain successfully treated with Ayurvedic approach. Conclusion: The above described sets of Panchakarma treatment along with Shamanoushadi has shown significant result clinically with speedy recovery within a month in the present Case study.
Clinical study to evaluate the efficacy of Mentosoothe Compound in the management of Attention Deficit / Hyperactivity Disorder
Authors: Kumawat Shraddha , Rakesh Kumar Nagar  , Vishal Nandlal Prajapati
Published: October 2023

Introduction: DSM-5 defines Attention-Deficit/Hyperactivity Disorder as having a persistent pattern of hyperactivity or inattention. This affects social, emotional, cognitive, and academic performance, behavioural skills in children and adolescents. The suffering child should have more than 6 symptoms of a particular type. Due to aetiology of   Dhee Dhriti and Smriti, which results in imbalance of Kala and Karma and leads to incorrect interaction of the senses with their aims (Asatmyendriyartha Samyoga), gives rise to inattention, hyperactivity and impulsivity. Considering the nature of symptomatologic manifestation, it can be correlated with Unmada, more specifically Vata-Pittaja Unmada. Ayurveda addresses ADHD with both internal medicines and external therapies. Mentosoothe compound is such a polyherbal compound it contains Medhya, Balya, Deepana and Rasayana drugs in extract form. Aim of the present study to evaluate the efficacy of mentosoothe compound in the management of Attention-Deficit/Hyperactivity Disorder. Objective of the study is to promote cognitive performance with improvement in the quality of life by providing an effective and safe treatment option. Materials and Methods: The present study will be conducted as a randomized clinical study including minimum 40 patients, divided into two groups. Mentosoothe compound A and Mentosoothe compound B will be given to groups with fixed dosages. Assessment will be done on every 15th day during 2 months of clinical trial and final follow up will be done one month after completion of clinical trial. Result:  The results will give the data on comparative effectiveness of the Mentosoothe compounds on ADHD. Discussion and Conclusion: The outcome of this trial will render a way forward to effective management of ADHD in children.
Cognitive Psychology: As essential & integrated part of medical education w.s.r. to Yukti Pramana in Ayurveda
Authors: Kshirabdhi Tanaya Rautaray  , Shiva Prasad Mohanty  , Raka Jain
Published: October 2023

Growth of any knowledge base depends on a dynamic continuum of a tripod of creating new knowledge through research, effective transfer of knowledge through proactive education and utilization of the knowledge with good professional practice. A set of knowledge system is likely to be relative to time & place setting which facilitates its need based development. But though Ayurvedic education system is one of the recognized age old education systems but still neither developed nor advanced alike other education system across the globe. Due to lack of maintenance of such dynamic continuum in current education system of ancient system of Indian medicine, the knowledge bases of Ayurveda becomes stagnant, static & gradually pass into merely history &may not remain dynamic & useful. Need of dynamism and activism through incorporation of cognitive psychology in education curriculum and enhancement of reasoning skill followed by critical thinking in the mind of medical professionals is quite necessary in the field of Ayurveda to make it up to date and develop it further in tune with the changing needs of the society today. Keeping this in view an effort has been made by the author to explore the concept of Yukti as key element of cognitive psychology make its relevant application in the field of current teaching & education and practice of Ayurved worldwide.
FEN BİLGİSİ ÖĞRETMEN ADAYLARIYLA GERÇEKLEŞTİRİLEN TEKNOLOJİ DESTEKLİ KAVRAMSAL DEĞİŞİM ETKİNLİKLERİNİN ETKİLERİ
Authors: Karyağdı Mukaddes , Aydın Güliz
Published: October 2023

Çalışmanın amacı, Fen Bilgisi öğretmen adaylarıyla gerçekleştirilen teknoloji destekli kavramsal değişim etkinliklerinin etkilerini ortaya koymaktır. Araştırma, nitel bir durum çalışmasıdır. Çalışma, ikinci sınıfta öğrenim görmekte olan 10 ikinci sınıf Fen Bilgisi öğretmen adayıyla gerçekleştirilmiştir. Veri toplama aracı olarak araştırmacılar tarafından geliştirilen kavramsal değişim değerlendirme soruları kullanılmıştır. Etkinliklere başlanmadan önce ve etkinlikler sona erdikten sonra öğretmen adaylarına kavramsal değişim değerlendirme soruları uygulanmıştır. Öğretmen adaylarına çevrim içi ortamda teknoloji destekli kavramsal değişim etkinliklerine yönelik bilgi verilip uygulama yapılmış; daha sonra onların Fen Bilimleri Öğretim Programı kapsamında teknoloji destekli kavramsal değişim etkinlikleri oluşturmaları sağlanmıştır. Öğretmen adayları, çevrim içi “Fen Bilgisi Öğretiminde Kavram Yanılgıları” derslerinde beş hafta süresince (10 ders saati) birlikte teknoloji destekli kavram haritaları, zihin haritaları, kavram karikatürleri ve kavramsal değişim metinleri oluşturmuşlardır. Öğretmen adayları kavram haritaları için “Inspiration” yazılımı, zihin haritaları için “MindManager” yazılımı, kavram karikatürleri ve kavramsal değişim metinleri için ise “Powtoon” web sitesini kullanmışlardır. Öğretmen adaylarından elde edilen nitel veriler, içerik analizine tabi tutulmuştur. Öğretmen adaylarının kavramsal değişim değerlendirme sorularına ilişkin uygulamadan sonraki cevaplarının, uygulamadan önceki cevaplarına göre daha bilimsel olduğu görülmüştür.
Impact of Covid-19 on the Tourism Industry of Himachal Pradesh
Authors: Devi Chhaya
Published: October 2023

The eruption of COVID-19 pandemic virus caused a challenge to the whole world, prevent or cure from its further spreading or survive with it, or revive of economy. To prevent from the spreading of virus government of India resisted lockdown which stops travel and tourism completely. Restrictions on global and interstate travel affected business sector exception allowed to daily need commodity its huge shock to nations economy. This research paper is investigating the results of covid-19 pandemic on economic growth in tourism sector. This paper is classified into following dimensions: domain of tourism facilities, tourists arrival and methodology. The aspects of this paper are focusing on tourism industry, including revenue impact, employment loss, issues facing by workers, market demand, recovery of the tourism industry, behavior of tourist for safety and health, preference of customers. Its analysis based on secondary data which discuss the pandemic activities and measuring the impression of the pandemic on the tourism industry in Himachal Pradesh.
Wizja kościelnych studiów wyższych na podstawie Veritatis Gaudium papieża Franciszka
Authors: Chrobak Stanisław , Urbančok Milan
Published: October 2023

Uniwersytet nieustannie podlega procesowi intensywnych przeobrażeń. Tytułowy dokument papieża Franciszka ukazuje aktualną panoramę nowych wyzwań w odniesieniu do tożsamości i działalności uniwersyteckiej. Papież, kierując się nauczaniem Soboru Watykańskiego II i doświadczeniem Kościoła zdobytym w minionych dziesięcioleciach, wskazuje na „kryteria odnowienia i odrodzenia wkładu studiów kościelnych w Kościół wychodzący na misję”. Ożywiając studia kościelne, dostrzega żywą potrzebę nadania nowego impulsu badaniom naukowym prowadzonym na uniwersytetach i wydziałach kościelnych. Chrześcijańska inspiracja pozwala uwzględniać w badaniach wymiar moralny, duchowy i religijny oraz oceniać zdobycze nauki i techniki z punktu widzenia integralnego dobra osoby ludzkiej. Chodzi zatem o to, by katolickie ideały, postawy i zasady przenikały i wypełniały różne formy działalności akademickiej, stosownie do ich natury i właściwej im autonomii.
Role of Metabolic Nutrition in Newborn Screening and Inherited Metabolic Disorders
Authors: Norris Marie , Kanungo Shibani
Published: October 2023

The expansion of newborn screening (NBS) encompasses a wide range of inherited metabolic disorders, including disorders of carbohydrate, lipid, and protein metabolism. Effective treatment of these disorders requires comprehensive nutrition and medical management. This review highlights the intricacies of medical nutrition therapy for several common metabolic disorders and underscores the crucial role of metabolic dietitians in managing these patients.
Maximizing the Benefit of Respite for Dementia Caregivers: A Study Protocol Describing the Development & Evaluation of the Time for Living & Caring (TLC) Intervention
Authors: Utz Rebecca L. , Caserta Michael , Iacob Eli , Sparks Catharine , Stark Louisa , Terrill Alexandra , Thompson Amber , Wong Bob
Published: October 2023

Dementia caregivers are susceptible to adverse physical and mental health outcomes, given the often prolonged and challenging care and support they provide to family members with Alzheimer’s Disease and Related Dementias (ADRD). This report describes a community-engaged implementation of a novel behavioral intervention - an “app” (interactive website) called TLC (Time for Living and Caring) that coaches caregivers on how to maximize the benefits associated with respite time. The rationale and features of the TLC intervention and the full research protocol used to develop and then evaluate its feasibility, acceptability, and initial efficacy are described here.
Evaluation of Bioactive Compounds Obtained from Ginkgo Biloba Against Crystal Structure of Myelin Oligodendrocyte Glycoprotein (MOG)
Authors: Gupta Aaryan , Roy Arpita , Pandit Soumya , Pandey Neha , Rustagi Sarvesh
Published: October 2023

Multiple Sclerosis (MS) spreads rapidly across the globe, causing almost 2.8 million cases worldwide. Many drugs and inhibitors, such as dronabinol and nabilone, have been used to treat MS, but there is no effective treatment for MS till now as these medications can cause severe side effects. So, we tested different compounds from Ginkgo biloba to inhibit the symptoms caused by MS as an herbal treatment. We targeted the Crystal structure of Myelin Oligodendrocyte Glycoprotein as it has shown some excellent results in experimental labs. In this article, the binding interactions through the molecular docking model was performed. Further compound's effectiveness through various screening protocols such as the ADME Test, Bioavailability Radar Test, and BOILED-Egg Test has been done. This study found that Amentoflavone and Isoginkgetin have the potential to inhibit the Crystal Structure of Myelin Oligodendrocyte Glycoprotein as they show the least binding energies which are -7.79 kcal/mol and -8.14 kcal/mol. To check the effectiveness of these compounds, Molecular Dynamics Simulations and in-vitro studies can be done to find some possible herbal treatments for Multiple Sclerosis.
A Serious Game to Train Rhythmic Abilities in Children With Dyslexia: Feasibility and Usability Study
Authors: Vonthron Francois , Yuen Antoine , Pellerin Hugues , Cohen David , Grossard Charline
Published: October 2023

Background

Rhythm perception and production are related to phonological awareness and reading performance, and rhythmic deficits have been reported in dyslexia. In addition, rhythm-based interventions can improve cognitive function, and there is consistent evidence suggesting that they are an efficient tool for training reading skills in dyslexia.

Objective

This paper describes a rhythmic training protocol for children with dyslexia provided through a serious game (SG) called Mila-Learn and the methodology used to test its usability.

Methods

We computed Mila-Learn, an SG that makes training remotely accessible and consistently reproducible and follows an educative agenda using Unity (Unity Technologies). The SG’s development was informed by 2 studies conducted during the French COVID-19 lockdowns. Study 1 was a feasibility study evaluating the autonomous use of Mila-Learn with 2500 children with reading deficits. Data were analyzed from a subsample of 525 children who spontaneously played at least 15 (median 42) games. Study 2, following the same real-life setting as study 1, evaluated the usability of an enhanced version of Mila-Learn over 6 months in a sample of 3337 children. The analysis was carried out in 98 children with available diagnoses.

Results

Benefiting from study 1 feedback, we improved Mila-Learn to enhance motivation and learning by adding specific features, including customization, storylines, humor, and increasing difficulty. Linear mixed models showed that performance improved over time. The scores were better for older children (P<.001), children with attention-deficit/hyperactivity disorder (P<.001), and children with dyslexia (P<.001). Performance improved significantly faster in children with attention-deficit/hyperactivity disorder (β=.06; t3754=3.91; P<.001) and slower in children with dyslexia (β=−.06; t3816=–5.08; P<.001).

Conclusions

Given these encouraging results, future work will focus on the clinical evaluation of Mila-Learn through a large double-blind randomized controlled trial comparing Mila-Learn and a placebo game.