bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigation of the Apoptosis Inducing and β-catenin Silencing by Tetradentate
Schiff Base Zinc(II) Complex on the T-47D Breast Cancer Cells
Authors: Majd Mostafa Heidari , Guo Xiangyu
Published: May 2023

Introduction:

Several mechanisms are known for the anticancer effects of cisplatin. However, its most wellknown
function involves binding to DNA and activating the DNA damage response.

Methods::

Despite its good effects, the treatment process often leads to chemoresistance and affects the mechanisms
that support cell survival, such as pathways that promote cell growth, apoptosis, DNA damage repair, and endocytosis.
For this reason, we investigated the effects of a new metal complex (tetradentate Schiff base zinc(II) complex) on
breast cancer cells (T-47D). We evaluated its effect on cytotoxicity, apoptosis, and drug resistance in comparison to
cisplatin.

Results:

The results of the MTT test showed that tetradentate Schiff base zinc(II) complex has good cytotoxicity compared
to cisplatin. The IC50 values for the [Zn(SB)]Cl2 complex and cisplatin after 72 h of exposure were equal to 42.1
and 276.1 μM, respectively. Real-time PCR assay confirmed that the [Zn(SB)]Cl2 complex activated the mitochondrial
pathway of apoptosis and increased the expression of Bak1 and caspase-3 genes significantly compared to cisplatin.
More importantly, the [Zn(SB)]Cl2 was able to reduce the expression of the β-catenin gene, which plays a role in drug
resistance, by 0.011 compared to the control.

Conclusion:

Therefore, we can hope for this new complex because, without the help of any β-catenin silencing agent,
it was able to inhibit the drug resistance in the T-47D cell line that overexpresses the β-catenin gene.
Bacterial Persister Cells: Mechanisms of Formation, Control, and Eradication
Authors: Kouhsari Ebrahim , Kaviar Vahab Hassan , Asadi Arezoo , Ahmadi Alireza , Sholeh Mohammad , Mirbalouchzehi Ali , Yaghoubi Sajad , Abdi Milad
Published: May 2023

Bacterial Persister Cells (BPCs) are quiescent, slow-growing or growth-arrested phenotypic
variants of normal bacterial cells that are transiently tolerant to antibiotics. It seems that persister cells
are the main cause of the recurrence of various chronic infections. Stress response (RpoS-mediated),
Toxin-Antitoxin (TA) systems, inhibition of ATP production, Reactive Oxygen Species (ROS), efflux
pumps, bacterial SOS response, cell-to-cell communication and stringent response (ppGpp- mediated)
are the primary potential mechanisms for persistence cell formation. However, eradicating persistent
cells is challenging as the specific molecular mechanisms that initiate their formation remain fuzzy and
unknown. Here we reviewed and summarized the current understanding of how bacterial persister cells
are formed, controlled, and destroyed.
Para um mapeamento multimodal do conceito de translanguaging com base em dados abertos
Authors: Araújo Sílvia , Pereira Mariana
Published: May 2023

Devido à crescente mobilidade e à promoção da internacionalização, as salas de aula são cada vez mais espaços de aprendizagem multilingues e multiculturais. Neste contexto, o translinguismo, conceito interdisciplinar que reconhece e abraça o bi/plurilinguismo dos aprendentes, contribui para o desenvolvimento das competências em língua materna e na(s) língua(s) alvo através da ativação estratégica do repertório linguístico em toda a sua plenitude. O translinguismo assume-se como uma prática pedagógica extremamente produtiva dado que pode ser aplicada em aulas de língua mas também noutras disciplinas que usam uma língua estrangeira para dar acesso ao conhecimento. Para mapear a rede de autores, conceitos relacionados, campos de pesquisa e definições que compõem o universo do translinguismo, é nosso objetivo propor uma metodologia de promoção da literacia da informação que una a escuta social à pesquisa e uso da informação científica através de ferramentas digitais de fácil utilização. Com esta metodologia, pretende-se que os professores possam adquirir, atualizar e/ou aprofundar, de forma autónoma e criativa, os seus conhecimentos sobre abordagens e estratégias inovadoras para o ensino de línguas, com vista a uma aprendizagem ao longo da vida.
Development of a software and hardware solution to identify trends in demand for goods
Authors: Miftahova A. I. , Yangirov E. I. , Karaseva E. I. , Yangirov A. I. , Nikulina E. Yu. , Drovnikova I. G.
Published: May 2023

Objective. The aim of the research work is to develop a software solution for identifying trends in demand for consumer goods by analyzing big data.

Method. To achieve this goal, the work analyzed the current state of development of the Internet retail market in Russia, as well as the technologies and tools for analyzing big data necessary for designing a software and hardware solution. To evaluate the effectiveness of the obtained data processing model, a sample obtained from open sources is used.

Result. As a result of the study, a technical solution has been developed that allows analyzing the demand for goods in a given time range based on data from open sources.

Conclusion. A software component has been developed to analyze the demand for consumer goods based on order data. The resulting technical solution supports batch processing of data, and the architecture of the infrastructure component allows distributed computing. Testing the tool on a real sample showed the effectiveness of this approach to analyzing consumer demand trends.
Field studies of a thermoelectric system for thermal action on the anterior segment of the human eyeball
Authors: Evdulov O. V. , Aminova I. Yu. , Aminov G. I. , Gasanova S. G. , Surakatova P. N.
Published: May 2023

Objective. The aim of the study is to develop the design of a thermoelectric system (TPS) for thermal action on the anterior segment of the human eyeball, as well as to conduct its field studies.

Method. The study is based on the methods of thermodynamic analysis, natural and computational modeling of processes and life support facilities.

Result. The design of TPP for thermal impact on the anterior segment of the human eyeball is presented. Its fullscale studies were carried out in accordance with the existing methods of thermophysical measurements. Curves of changes in the temperature of the surface of the gelatin model of the human eyeball over time during cooling and heating were obtained for the supply currents of the thermoelectric module (TEM) included in the TPP, equal to 2.5 A, 3 A, 3.5 A, A and 1 A, 1 .2 A, 1.4 A, as well as changes in the temperature of the object of influence over time when changing the cooling mode to heating and vice versa. To assess the possibilities of heat removal from the hot junctions of TEMs in the system, data were obtained on the change in their temperature over time during the cooling effect for various values of the module supply current.

Conclusion. It has been established that standard modules produced by domestic firms can be used as TEMs in the system. The duration of entering the TPP mode is about 230 s. The refore, it seems appropriate to bring the TPP to the operating mode before the actual procedures are carried out. It has been established that the duration of TPP switching from cooling to heating mode and vice versa is 230 s, which requires further optimization of the design and operating modes of the device through the use of more advanced types of TEMs and the use of forced operation of thermal modules in the transient mode.
Detection of hidden defects of thermal protection of buildings and determination of some thermal properties of structural building materials by Non-destructive Thermal Imaging method
Authors: Karpov D. F. , Pavlov M. V. , Gudkov A. G.
Published: May 2023

Objective. The purpose of the work is the practical approbation of a nondestructive thermal imaging method to identify hidden (invisible) defects and qualitative analysis of the thermal protection of a complex of construction objects in the city of Vologda, as well as the study of some physical (thermophysical) indicators (coefficients of thermal conductivity, thermal resistance (thermal insulation) and heat transfer) of structural building material in the form of silicate brick.

Method. The fundamental laws of the theory of heat transfer, thermal nondestructive testing, infrared and technical diagnostics, the current domestic regulatory and technical and regulatory documentation, field experiments on real objects and laboratory samples.

Result. The results of the practical determination of hidden defects in the thermal shells of the complex of civil and industrial buildings functioning in the urban environment, thermophysical properties (coefficients of thermal conductivity, thermal resistance (thermal insulation), heat transfer) of modern building materials by methods of thermal non-destructive testing are presented. The locations of identified invisible defects of thermal protection of the surveyed construction objects are determined and recommendations for their elimination are proposed. The obtained values of thermophysical characteristics for the studied structural building material are consistent with the data of current regulatory documents.

Conclusion. The features of the nondestructive method of infrared thermography in determining the hidden defects of the heatshielding shells of operated buildings of various functional purposes and the complex of thermophysical parameters of modern structural building materials are shown. The demand for thermal imaging during energy and technical surveys of construction objects, their individual structural elements, life support engineering systems, as well as studies on the refinement, quantification and prediction of various thermal properties of building materials and products has been experimentally confirmed.
New types of membrane-rod and membrane-pneumatic structures and improved methods for their calculation
Authors: Kim A. Yu. , Polnikov S. V. , Amoyan M. F.
Published: May 2023

Objective. The purpose of this study was to create new pre-fabricated membrane-rod structures and non-linear methods for their calculation.

Method. A stepwise method with an iterative numerical Euler-Cauchy procedure of the third order of accuracy was applied with the use of the finite element method at the step.

Result. A technique for static calculation of membrane-rod structures has been developed, taking into account nonlinear factors. A calculation algorithm has been compiled and a program for calculating such structures has been written according to it. For this program, a certificate was obtained on the computer No. 2017613415 "Program for calculating membrane-pneumatic structures, taking into account non-linear factors by the iterative method of incrementing parameters."

Conclusion. It is recommended to use a one-step calculation of membrane-rod systems with five iterations per step or a multi-step calculation with five steps with one iteration per step. Mixed options are also effective.
Spatial large-span structures
Authors: Yusupov A. K. , Muselemov H. M. , Vishtalov R. I.
Published: May 2023

Objective. This article discusses spatial large-span structures; provides features of their work; as well as layout examples. General dimensions and ways of stabilizing displacements are given.

Method. The features of the work and layout of spatial large-span structures; as well as calculation formulas are given. The types of sections and nodes of conjugation of elements are presented. A technique is described that allows stabilizing the movements of largespan pavements.

Result. The given structural schemes; as well as the analysis of their work; allow designing large-span spatial systems in the form of convex and concave structures that have high reliability; minimal weight; and high manufacturability in manufacturing; transportation and installation.

Conclusion. The proposed rational design solutions make it possible to reduce the own weight of spatial convex and concave coatings; which have the necessary rigidity; strength and stability. The types of structural schemes; sections and junctions of elements considered in the article are widely used in the practice of design and construction.
Analysis and features of the functioning of protected automated systems of internal affairs bodies under the influence of threats of unauthorized access
Authors: Yefimov A. O. , Nasedkina V. S. , Popov A. D. , Rogozin E. A. , Romanova V. R.
Published: May 2023

Objective. The purpose of the study is to analyze the features of the functioning of protected automated systems and develop a structural diagram of a typical ATS AS, which includes various structural elements.

Method. As a fundamental method of conducting research is the method of system analysis.

Result. Based on the developed typical structural diagram of the ATS AS, threats to web servers were identified in accordance with the official website of the FSTEC, and, in accordance with them, potential vulnerabilities (weak points in terms of information security) were identified; a classification of all potentially dangerous threats to the information resource of protected ATS automated systems was developed and presented.

Conclusion. The materials of the article can be used to analyze and develop a methodology for quantitatively assessing the risks of information security violations of the web servers of the ATS of the Russian Federation; methods for assessing the level of security of the ATS of the Russian Federation; methods of access of regular users of the RF ATS AS to the information resource of these systems based on semantic analysis.
Principles of construction of a multifunctional intelligent electric energy meter with advanced communication and functional capabilities
Authors: Magomedov I. A. , Khidivov M. N. , Magomedov A. I.
Published: May 2023

Objective.Development of principles for the construction of a multifunctional intelligent electric energy meter (MSE) with expanded communication and functional capabilities and the construction of MSE based on them for automated systems of commercial accounting of energy consumption (ASKUE).

Method.When developing the principles of the construction of the IEE, an analysis of existing electric energy metering devices was carried out and their main disadvantages were identified, which made it possible to improve the characteristics and expand the functionality of metering devices. The operability of the main components of the IEE is confirmed by the results of mathematical and physical modeling, which showed the possibility of improving the metrological characteristics and technical parameters that determine the quantitative, qualitative and cost characteristics of the devices.

Result. The principles of the construction of the IEE have been developed, which makes it possible to create IEE with expanded communication and functional capabilities for the ASUE.

Conclusion. Using them in ASCUE posvolit: -to build self-adjusting mesh networks based on them, which can be used in the construction of ASCS with increased survivability; -to ensure the exchange of accounting and service information with the ASKUE over the radio channel, PCL modem and RS-485 (CAN) interface, which increases the reliability of obtaining accounting information and integrate the MISEE into existing ASKUE, because it makes it possible to select the appropriate type of specific ASKUE interface or communication interfaces "counter-ASKUE";- regulate energy consumption and independent disconnection of the consumer from the network for each subscriber unit (separately for each subscriber) in case of arrears of payments, network overload and unauthorized access to the nodes and blocks of the meter in various ways;- to improve the operating conditions of the meter when organizing electronic payments and increasing the reliability of accounting information due to contactless remote removal of information by means of communication interfaces for each subscriber or by means of an individual remote control (remote control).-to reduce the hardware costs of servicing one subscriber associated with the use of the main units and units of the meter to account for energy consumption for all subscribers, and, as a result, the low cost of electricity metering in recalculation per subscriber.
Afstellen en afstemmen van geneesmiddelen bij kanker
Authors: Jansman Frank
Published: May 2023

In zijn oratie betoogt Frank Jansman dat de behandeling met geneesmiddelen bij kanker voor verbetering vatbaar is: enerzijds geldt dit voor het bepalen van de juiste doseringen op geleide van de individuele patienten- en ziektekenmerken. Anderzijds gebruikt de patient met kanker vaak een palet aan geneesmiddelen, polyfarmacie genoemd. Bij antikankerbehandeling moet het volledige geneesmiddelengebruik worden geevalueerd en aangepast. Ongewenste geneesmiddelen kunnen worden gestopt en gewenste, ontbrekende geneesmiddelen worden toegevoegd. Dit leidt tot een betere werkzaamheid, minder bijwerkingen en lagere kosten. Het onderzoek van Jansman richt zich een zorgvuldige begeleiding van geneesmiddelengebruik en op de klinische farmacologie van geneesmiddelen bij kanker. Zijn specifieke onderzoek en activiteiten op gebied van interacties met oncologische middelen hebben geleid tot opname hiervan in het geautomatiseerde medicatiebewakingssysteem, waarvan apothekers en artsen in Nederland gebruik maken bij het voorschrijven. Jansman zal in zijn oratie met voorbeelden laten zien waarin de behandeling met geneesmiddelen bij kanker kan worden verbeterd. Zo is het gebruik van oxycodon ongeschikt bij patienten die een veel toegepast middel bij prostaatkanker gebruiken. Ook blijkt uit zijn onderzoek dat maar liefst bij 80% van oudere patienten met kanker aanpassing van het geneesmiddelgebruik gewenst is.
Epidemiology and a Predictive Model of Prognosis Index Based on Machine Learning in Primary Breast Lymphoma: Population-Based Study
Authors: Yu Yushuai , Xu Zelin , Shao Tinglei , Huang Kaiyan , Chen Ruiliang , Yu Xiaoqin , Zhang Jie , Han Hui , Song Chuangui
Published: May 2023

Background

Primary breast lymphoma (PBL) is a rare disease whose epidemiological features, treatment principles, and factors used for the patients’ prognosis remain controversial.

Objective

The aim of this study was to explore the epidemiology of PBL and to develop a better model based on machine learning to predict the prognosis for patients with primary breast lymphoma.

Methods

The annual incidence of PBL was extracted from the surveillance, epidemiology, and end results database between 1975 and 2019 to examine disease occurrence trends using Joinpoint software (version 4.9; National Cancer Institute). We enrolled data from 1251 female patients with primary breast lymphoma from the surveillance, epidemiology, and end results database for survival analysis. Univariable and multivariable analyses were performed to explore independent prognostic factors for overall survival and disease-specific survival of patients with primary breast lymphoma. Eight machine learning algorithms were developed to predict the 5-year survival of patients with primary breast lymphoma.

Results

The overall incidence of PBL increased drastically between 1975 and 2004, followed by a significant downward trend in incidence around 2004, with an average annual percent change (AAPC) of −0.8 (95% CI −1.1 to −0.6). Disparities in trends of PBL exist by age and race. The AAPC of the 65 years or older cohort was about 1.2 higher than that for the younger than 65 years cohort. The AAPC of White patients is 0.9 (95% CI 0.0-1.8), while that of Black patients was significantly higher at 2.1 (95% CI −2.5 to 6.9). We also identified that the risk of death from PBL is multifactorial and includes patient factors and treatment factors. Survival analysis revealed that the patients diagnosed between 2007 and 2015 had a significant risk reduction of mortality compared to those diagnosed between 1983 and 1990. The gradient booster model outperforms other models, with 0.752 for sensitivity and 0.817 for area under the curve. The important features established with the gradient booster model were the year of diagnosis, age, histologic type, and primary site, which were the 4 most relevant variables to explain 5-year survival status.

Conclusions

The incidence of PBL started demonstrating a tendency to decrease after 2004, which varied by age and race. In recent years, the prognosis of patients with primary breast lymphoma has been remarkably improved. The gradient booster model had a promising performance. This model can help clinicians identify the early prognosis of patients with primary breast lymphoma and therefore improve the clinical outcome by changing management strategies and patient health care.
Problems and Barriers Related to the Use of Digital Health Applications: Scoping Review (Preprint)
Authors: Giebel Godwin Denk , Speckemeier Christian , Abels Carina , Plescher Felix , Börchers Kirstin , Wasem Jürgen , Blase Nikola , Neusser Silke
Published: May 2023

BACKGROUND

The digitization of health care led to a steady increase in the adoption and use of mobile health (mHealth) apps. Germany is the first country in the world to cover the costs of mHealth apps through statutory health insurance. Although the benefits of mHealth apps are discussed in detail, aspects of problems and barriers are rarely studied.

OBJECTIVE

This scoping review aimed to map and categorize the evidence on problems and barriers related to the use of mHealth apps.

METHODS

Systematic searches were conducted in the MEDLINE, Embase, and PsycINFO databases. Additional searches were conducted on JMIR Publications and on websites of relevant international organizations. The inclusion criteria were publications dealing with apps similar to those approved in the German health care system, publications addressing problems and barriers related to the use of mHealth apps, and articles published between January 1, 2015, and June 8, 2021. Study selection was performed by 2 reviewers. The manuscript was drafted according to the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) checklist. The analysis of the included publications and categorization of problems and hurdles were performed using MAXQDA (VERBI Software GmbH).

RESULTS

The database search identified 1479 publications. Of the 1479 publications, 21 (1.42%) met the inclusion criteria. A further 8 publications were included from citation searching and searching in JMIR Publications. The identified publications were analyzed for problems and barriers. Problems and barriers were classified into 10 categories (“validity,” “usability,” “technology,” “use and adherence,” “data privacy and security,” “patient-physician relationship,” “knowledge and skills,” “individuality,” “implementation,” and “costs”). The most frequently mentioned categories were use and adherence (eg, incorporating the app into daily life or dropouts from use; n=22) and usability (eg, ease of use and design; n=19).

CONCLUSIONS

The search identified various problems and barriers in the context of mHealth apps. Although problems at the app level (such as usability) are studied frequently, problems at the system level are addressed rather vaguely. To ensure optimal use of and care with mHealth apps, it is essential to consider all types of problems and barriers. Therefore, researchers and policy makers should have a special focus on this issue to identify the needs for quality assurance.

INTERNATIONAL REGISTERED REPORT

RR2-10.2196/32702
Assessing Disparities in Video-Telehealth Use and eHealth Literacy Among Hospitalized Patients: Cross-sectional Observational Study (Preprint)
Authors: Cheng Jessica , Arora Vineet M , Kappel Nicole , Vollbrecht Hanna , Meltzer David O , Press Valerie
Published: May 2023

BACKGROUND

Medicare coverage for audio-only telehealth is slated to end this year after the public health emergency concludes. When the time comes, many patients may be unable to make the transition from audio-only to video telehealth due to digital inexperience. This study explores the second digital divide within video telehealth use, which is primarily characterized by skills and capabilities rather than access, by measuring eHealth literacy (eHL) and video capabilities in hospitalized patients.

OBJECTIVE

The aim of this study is to evaluate video capabilities, eHealth literacy, and engagement with video telehealth among hospitalized patients.

METHODS

The study design is a cross-sectional observational study of adult inpatients at the University of Chicago Medical Center. We assessed self-reported rates of audio versus video telehealth usage as well as the participants’ self-reported willingness to use video telehealth for future health care visits. We used a multivariable binary logistic regression to determine the odds ratio for being unwilling to use video telehealth, adjusted for age, sex, race or ethnicity, educational level, eHL literacy scale (eHEALS), health literacy (brief health literacy screen), technology access, internet access, and video capability.

RESULTS

Of the 297 enrolled participants, median age was 58 years, most (n=185, 62%) identified as Black, half (n=149, 50%) were female, one-quarter (n=66, 22%) lacked home internet access, and one-third (n=102, 34%) had inadequate eHL.

CONCLUSIONS

Patients with low eHL reported greater participation in audio-only telehealth over video telehealth, of which the former may lose its flexible pandemic reimbursement policy. This may widen the existing health disparities as older adults and patients with low eHL face challenges in accessing video telehealth services. Low eHL is associated with lack of web-based skills, lower rates of video telehealth usage, and lower willingness to use video technology. The study results raise the question of how to improve video capability among patients who, despite having access to smartphones and laptops, face challenges in using telehealth optimally.
Pembangunan Pariwisata di Sekitar Slum Area Perkotaan:Dari Marginalisasi Menuju Transformasi
Authors: Syafrini Delmira , Nurlizawati Nurlizawati , Wirdanengsih Wirdanengsih , Permata Bunga Dinda
Published: May 2023

Makalah ini bertujuan untuk menjelaskan bagaimana pengembangan pariwisata yang dilakukan di sekitar kawasan Slum Area perkotaan, serta dampaknya terhadap transformasi kawasan dan komunitas lokal, dengan studi kasus kawasan pemukiman kumuh yang dihuni komunitas Nelayan di Pantai Purus Kota Padang. Hal ini menarik, karena kawasan di sekitar Pantai Purus dulunya diidentikkan dengan slum area yang dihuni oleh komunitas nelayan dengan streotipe yang negative, namun saat ini tumbuh menjadi lokasi pariwisata pantai andalan Kota Padang, bahkan nelayan menjadi bagian penting pembentuk dayatarik dan sense of place dalam pariwisata. Penelitian ini menggunakan pendekatan kualitatif, dengan tipe studi kasus. Data diperoleh melalui observasi, wawancara dan studi dokumentasi. Observasi dilakukan untuk mengamati proses interaksi yang terjadi antara penduduk lokal dengan wisatawan, serta mengamati bagaimana mereka terlibat dalam berbagai aktivitas wisata. Sementara itu wawancara dilakukan dengan 22 informan, yang berasal dari berbagai kalangan, seperti pengambil kebijakan, komunitas yang tinggal di sekitar pantai, pedagang dan wisatawan  untuk mengetahui bagaimana proses pengembangan pariwisata, yang berdampak pada transformasi kawasan dan komunitas yang tinggal di sekitar Pantai Purus. Temuan penelitian menunjukkan bahwa pengembangan pariwisata telah mengubah kawasan ini, dari kawasan yang kumuh yang dihindari menjadi lokasi yang dikunjungi. Nelayan yang dulunya merasa menjadi kelompok yang menolak pembangunan pariwisata karena menjadi kelompok marginal, namun saat ini bertranformasi menjadi komunitas pendukung pariwisita. Pariwisata tidak hanya mengubah ruang dan fisik kawasan tetapi juga kehidupan sosial ekonomi dan budaya komunitas nelayan yang tinggal di sekitar kawasan.
Effect of aloe vera on the proliferation phase of oral mucosal wound healing in rats
Authors: Primasari Ameta , Yendriwati Yendriwati , Minasari Minasari , Buaya Erlin Kristiani , Madani Sri Ayu Winda , Sembiring Kartika Nabila , Hidayati Rizka
Published: May 2023

Aloe vera is known as a medicinal plant containing an active substance acemannan thought to play a role in accelerating wound healing. This study aims to determine the effect of aloe vera extract on the proliferation phase of oral mucosa wound healing in rats by looking at epithelial thickening, epithelial gaps closure, growth of new blood vessels, and connective tissue growth. This research is a pure experimental study with a post-test only control group design. On the left buccal mucosa of the mouth of 24 white Wistar rats (n = 24), an incision was made by scalpel with 10 mm length and 2.5 mm depth. The rats were divided into 4 groups: groups 1 and 2 as controls, while groups 3 and 4 were applied with aloe vera extract made by maceration technique. Wound tissue was observed histologically with Hematoxylin-Eosin staining under a microscope with an image analyzer for measuring the thickness of epithelium. The analysis of epithelial gap width used morphometry, and the number of capillaries was counted manually. Connective tissue thickness was measured with Image-J software. These were carried out on days 7 and 14 after treatment and the data were analyzed with the independent t-test and Mann-Whitney test. The results showed that aloe vera extract had no significant effect on epithelial thickening on day 7 (p = 0.701) nor on day 14 (p = 0.639), but a significant effect was shown on epithelial gaps closing (p = 0.049), connective tissue thickening (p = 0.004), and capillary increase on day 7 (p = 0.049). It could be concluded that aloe vera extract could potentially accelerate the epithelial gaps closure, connective tissue thickening, and capillary increase during the proliferation phase of the oral mucosa wound healing.
Faktor-Faktor Pencarian Informasi Inovasi Pertanian dalam Meningkatkan Manajemen Sumber Daya Manusia
Authors: Juniarti Hafni Amalia , Nugroho Novendra Cahyo , Suprihanto John
Published: May 2023

Diseminasi informasi pertanian merupakan sarana pembangunan dan peningkatan kualitas Sumber Daya Manusia (SDM) pertanian. Pengetahuan yang teradopsi dan diaplikasikan pada  usaha tani berpengaruh dengan meningkatkan kualitas dan nilai ekonomi produk pertanian, sehingga kesejaheteraan hidup SDM pertanian meningkat. Perlu diketahui, keterbatasan kualitas SDM berdampak pada adopsi informasi dan inovasi yang mempengaruhi kualitas produk pertanian serta pendapatan petani. Kebun Buah Cepoko merupakan salah satu aset pemerintah yang menjadi sumber informasi inovasi terkait tanaman hortikultura untuk petani maupun masyarakat umum lainnya. Penelitian ini bertujuan untuk:mengetahui karakteristik petani pencari informasi; mengetahui faktor petani mencari informasi inovasi pertanian; dan menganalisis pengaruh karakteristik petani pencari informasi terhadap faktor petani pencari informasi. Metode analisis data menggunakan statistik deskriptif dan analisis regresi berganda menggunakan SPSS versi 25. Berdasarkan hasil penelitian disimpulkan, pertama karakteristik petani pencari informasi mayoritas berumur 28-67 tahun, pengalaman usaha tani selama 7-10 tahun, dan berjenis kelamin perempuan; kedua faktor petani mencari informasi terdiri dari petani berpendidikan SMA, Frekuensi berkunjung ke Kebun Buah Cepoko, Nilai manfaat ekonomi komoditas, tingkat kosmopolitan petani, jenis informasi yang dibutuhkan adalah informasi budidaya; Ketiga hasil model persamaan regresi linier berganda adalah 𝑌 = 21.47 -1.85X1 + 4.61X2. Tidak terdapat perbedaan pencarian informasi inovasi pertanian antara petani laki-laki dan perempuan.
Optimalisasi Layanan Perpustakaan Fakultas Biologi Universitas Gadjah Mada melalui Kolaborasi Pustakawan dengan Volunteer Perpustakaan
Authors: Nuraini Rusna
Published: May 2023

Peran lebih pustakawan dalam pengelolaan sebuah perpustakaan, serta dalam penyediaan  akses sumber belajar bagi pemustaka sangat dibutuhkan di Fakultas Biologi Universitas Gadjah Mada. Perkembangan teknologi dan komunikasi di era saat ini menjadi sebuah peluang dan tantangan bagi pustakawan untuk mengembangkan layanan yang lebih berkualitas dengan mengikuti trend perubahan zaman. Oleh karena itu, kolaborasi antara pustakawan dengan mahasiswa volunteer perpustakaan yang bertujuan untuk membangun kesesuaian layanan perpustakaan pada era saat ini sangat dirasakan manfaatnya. Volunteer perpustakaan terdiri dari beberapa mahasiswa terpilih yang memiliki ketertarikan dan komitmen yang kuat untuk bergabung dengan perpustakaan dalam berbagai kegiatan agar layanan bagi pemustaka semakin berkualitas. Berbagai kolaborasi kegiatan yang telah dilakukan antara lain,  training of trainer tentang penelusuran akses database jurnal elektronik dan manajemen sitasi menggunakan Mendeley, talk show diskusi bedah buku, kegiatan pengabdian masyarakat, pelatihan akses e resources, manajemen sitasi Mendeley, dan Microsoft Word tingkat lanjut, sosialisasi layanan perpustakaan dan bimbingan literasi informasi bagi mahasiswa baru dengan pelatihan penelusuran akses jurnal elektronik dan manajemen sitasi menggunakan Mendeley, dan hibah inovasi tenaga kependidikan 2020 berupa kegiatan inovasi layanan perpustakaan selama pandemi. Kolaborasi tersebut menjadikan perpustakaan sebagai wadah kreasi mahasiswa untuk memberikan kontribusi nyata yang dapat dirasakan manfaatnya bagi civitas akademika Fakultas Biologi Universitas Gadjah Mada dalam upaya optimalisasi layanan perpustakaan di Fakultas Biologi UGM.
Perpustakaan dalam Bayang-bayang Transformasi Metaverse
Authors: Agung Nugrohoadhi
Published: May 2023

ABSTRAK

Teknologi informasi  begitu kuat dalam mempengaruhi dunia kerja perpustakaan khusunya dalam mengakses informasi. Koleksi  perpustakaan yang semakin beragam tidak hanya berbentuk tercetak namun sudah dalam bentuk softcopi  sehingga semakin mudah dalam diseminasi informasi . Keberagaman koleksi  koleksi yang dilayankan tentunya akan memberikan keleluasaan pemustaka dalam mendayaagunakan koleksi  yang diinginkannya sehingga dapat mendukung  tidak saja aktivitas belajar mengajar, namun juga dapat mendukung dalam pengembangan kegiatan penelitian Digayutkan dengan perkembangan teknologi informasi yang selama ini banyak dipergunakan dalam dunia perpustakaan maka transformasi layanan semakin berkembang.  Maka seharusnya perpustakaan akan semakin membantu mempermudah pemustaka dalam mencari informasi . Metaverse sebagai sebuah teknologi maya dapat memberikan sumbangan transformasi layanan yang berbanding lurus dengan siapa pemustaka yang dilayaninya . kalau kita berbicara siapa pemustaka kita saat ini maka tidak lain tidak bukan adalah pemustaka milenial sebagai generasi yang lahir pada era teknologi informasi yang sangat berkembang dengan pesat. Generasi ini begitu lahir sudah dikelilingi oleh berbagai perangkat sosial media milik orang tuanya. Sehingga teknologi metaverse ini akan mempermudah dalam setiap upaya pencarian informasi.
Calcitonin receptors in GtoPdb v.2023.1
Authors: Garelja Michael L. , Hay Debbie , Poyner David R. , Walker Christopher S.
Published: May 2023

This receptor family comprises a group of receptors for the calcitonin/CGRP family of peptides. The calcitonin (CT), amylin (AMY), calcitonin gene-related peptide (CGRP) and adrenomedullin (AM) receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on CGRP, AM, AMY, and CT receptors [131, 74, 71]) are generated by the genes CALCR (which codes for the CT receptor, CTR) and CALCRL (which codes for the calcitonin receptor-like receptor, CLR, previously known as CRLR). Their function and pharmacology are altered in the presence of RAMPs (receptor activity-modifying proteins), which are single TM domain proteins of ca. 150 amino acids, identified as a family of three members; RAMP1, RAMP2 and RAMP3. There are splice variants of the CTR; these in turn produce variants of AMY receptors [131], some of which can be potently activated by CGRP. The endogenous agonists are the peptides calcitonin, α-CGRP (formerly known as CGRP-I), β-CGRP (formerly known as CGRP-II), amylin (occasionally called islet-amyloid polypeptide, diabetes-associated polypeptide), adrenomedullin and adrenomedullin 2/intermedin. There are species differences in peptide sequences, particularly for the CTs. CTR-stimulating peptide (CRSP) is another member of the family with selectivity for the CTR but it is not expressed in humans [93]. CLR (calcitonin receptor-like receptor) by itself binds no known endogenous ligand, but in the presence of RAMPs it gives receptors for CGRP, adrenomedullin and adrenomedullin 2/intermedin. There are several approved drugs that target this receptor family, such as pramlintide, erenumab, and the "gepant" class of CGRP receptor antagonists. There are also species differences in agonist pharmacology; for example, CGRP displays potent activity at multiple rat and mouse receptors [58, 15]. The summary table only reflects human receptor pharmacology.
Endothelin receptors in GtoPdb v.2023.1
Authors: Abraham George R. , D'Orléans-Juste Pedro , Davenport Anthony P. , Godfraind Théophile , Maguire Janet J. , Ohlstein Eliot H. , Ruffolo Robert R. , Williams Thomas L.
Published: May 2023

Endothelin receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Endothelin Receptors [24]) are activated by the endogenous 21 amino-acid peptides endothelins 1-3 (endothelin-1, endothelin-2 and endothelin-3).
Apelin receptor in GtoPdb v.2023.1
Authors: Davenport Anthony P. , Kleinz Matthias , Maguire Janet J. , Williams Thomas L. , Yang Peiran
Published: May 2023

The apelin receptor (nomenclature as agreed by the NC-IUPHAR Subcommittee on the apelin receptor [73] and subsequently updated [75]) responds to apelin, a 36 amino-acid peptide derived initially from bovine stomach. apelin-36, apelin-13 and [Pyr1]apelin-13 are the predominant endogenous ligands which are cleaved from a 77 amino-acid precursor peptide (APLN, Q9ULZ1) [88]. A second family of peptides discovered independently and named Elabela [13] or Toddler, that has little sequence similarity to apelin, is present, and functional at the apelin receptor in the adult cardiovascular system [97, 71]. The enzymatic pathways generating biologically active apelin and Elabela isoforms have not been determined but both propeptides include sites for potential proprotein convertase processing [81]. Structure-activity relationship Elabela analogues have been described [65, 90]. The stoichiometry of apelin receptor-heterotrimeric G protein complexes has been studied using cryogenic-electron microscopy [98].
Bile acid receptor in GtoPdb v.2023.1
Authors: Bonner Tom I. , Davenport Anthony P. , Hills Rebecca , Maguire Janet J. , Rosser Edward
Published: May 2023

The bile acid receptor (GPBA) responds to bile acids produced during the liver metabolism of cholesterol. Selective agonists are promising drugs for the treatment of metabolic disorders, such as type II diabetes, obesity and atherosclerosis.
Study of Machine Learning Methods to Predict and Prevent Gas Hydrate Formation
Authors: Inamdar Satish , Pustode Prajwal , Bari Ritesh , Wasnik Rahul , Patil Abhishek , Koyale Shreyash
Published: May 2023

Abstract: Formation of gas hydrates are a serious concern in oil and gas production systems. The formation and possible deposition of hydrates usually occur in suitable conditions, specifically as the gas-phases of reservoir fluid interact with water molecules. Hydrate formation represents a significant risk to process safety as it can result in the plugging of both pipes and instruments. Hydrates typically form in process where light hydrocarbons, water vapor and low temperatures or high pressures are present. We have studied the conditions under which hydrates form, how formation may be prevented and what can be done once hydrates have formed.
Smart Shoe for Visually Impaired
Authors: V Nivedhitha , B Praba , SR Priyavarshini , A Aarthi , K Rajakumari
Published: May 2023

Abstract: Our eyes are undoubtedly the most precious gift we have and play a significant part in our daily life. We are fortunate to have sight, so we can see this world. However, some individuals struggle to visualize these things. Because of this, moving around in strange public settings presents several difficulties for those with vision impairment. 39 million individuals are blind and 246 have limited vision, making up the estimated 285 million visually impaired persons globally. Wearable technology should be created with these people's visual impairments in mind. Smart shoes are a wearable technology created to give persons with vision impairments navigational information. In this study, a sophisticated electronic assistive device for the blind prototype model and system design are given. This system's components—a microprocessor, an ultrasonic sensor, and a Bluetooth headphone—are made to provide general measures for object detection, human detection, and real-time help. A pair of smart shoes equipped with water and ultrasonic sensors. A Bluetooth connection between the shoe and an Android application will enable voice control support for the user. The user will be assisted in moving about autonomously by the Smart Shoes and the Android application.
Multiple Disease Detection Web App
Authors: Jagadish Madikonda , Pulluri Anudeep , Gollapally Aryan Goud , Yellamma M.
Published: May 2023

Abstract: Artificial intelligence and machine learning are quite significant in the modern world. They are present in every sector, including the medical sector and autonomous vehicles. The medical industry produces vast amounts of patient data, which is then processed in a variety of ways. Consequently, we were able to create a prediction system that can recognize numerous diseases at once using machine learning. Many of the methods in use now can predict only one disease at a time, and that too with reduced accuracy. Reduced precision can seriously jeopardize a patient's health. The three illnesses we are now considering are diabetes, liver, and heart, but there may be many more added in the future. Several parameters must be entered by the user. When the user enters many disease-related parameters, the system will output whether the user has the disease or not. This initiative can help a lot of people because it makes it possible to monitor someone's health and take the appropriate steps to extend their lives.
Smart Accident Detection and Alert System using Accelerometer, GPS and GSM Module with Integrated Functionality of Alcohol Detection
Authors: Shrivastava Vasudev , Gandhi Prof. Shivangi
Published: May 2023

Abstract: The Smart Accident Alert System is a comprehensive solution created to identify accidents and transmit alerts to the authorities in real-time. It uses IOT and integrates GPS, Accelerometer, GSM, and MQ3 Sensor. To enable precise and accurate accident detection and reporting, this system makes use of a number of technologies, including GPS, Accelerometer, GSM, and MQ3 Sensor. The system functions by continuously tracking a vehicle's motions and evaluating the sensor data. When an accident occurs, the system immediately alerts the emergency services and notifies the registered user to let them know. The IOTbased Smart Accident Alert System offers a trustworthy and effective means to identify accidents, shortening response times and sparing priceless lives
Early Diagnosis of Lung Cancer with Advanced ALCDC System and Deep Learning-Based CNN Algorithm
Authors: Dawalkar Krishna , Joshi Omkar , Mantri Priti , Wankar Vaishnao , Bhosale Prof. M.S.
Published: May 2023

Abstract: This research paper presents a study on the use of an advanced ALCDC system, which utilizes a deep learning-based convolutional neural network (CNN) algorithm, for early detection of lung cancer. The purpose of this study is to evaluate the effectiveness of this system in detecting lung cancer at an early stage and to compare its performance with traditional detection methods.Lung cancer is the leading cause of cancer-related deaths worldwide, with a high mortality rate due to late diagnosis. Therefore, early detection of lung cancer is crucial for successful treatment and improving patient outcomes. Traditional methods of lung cancer detection, such as chest X-rays and CT scans, have limitations in terms of accuracy and efficiency. Recent advancements in AI and deep learning algorithms, such as CNNs, have shown promise in improving the accuracy and efficiency of lung cancer detection.In comparison to traditional detection methods, the ALCDC system showed a significant improvement in accuracy and efficiency. The system was able to detect lung nodules at an earlier stage, which is critical for successful treatment and improving patient outcomes.
PINJAMAN EMAS PADA UPK AMANAH SYARIAH DALAM PERSPEKTIF HUKUM ISLAM
Authors: Mahdalena Nasrun  , Bustamam Usman  , Yana Ilham Sari
Published: May 2023

Lembaga-lembaga yang bergerak dibidang permodalan memiliki sistem atau cara tersendiri dalam menyalurkan modal, seperti pada UPK Amanah Syariah yang merupakan lembaga pengelola kegiatan untuk mengatasi dan membantu dalam bidang ekonomi, dilakukan secara swadaya dalam mengembangkan kesejahteraan masyarakat. Permodalan yang diberikan dalam bentuk pinjaman atau hutang-piutang dengan objeknya emas. Fokus permasalahan dalam penelitian ini adalah bagaimana pertimbangan UPK Amanah Syariah memberikan pinjaman dalam bentuk emas, penetapan bagi hasil dari tambahan jasa pinjaman dan bagaimana tinjauan ekonomi Islam terhadap pengelolaan bagi hasil dalam praktik pinjaman emas pada UPK Amanah Syariah. Penelitian ini merupakan penelitian lapangan dengan melakukan wawancara dan dokumentasi, adapun metode analisis data adalah deskriptif kualitatif. Penelitian ini menyimpulkan pertama pertimbangan pemberian pinjaman dalam bentuk emas karena berdasarkan hasil musyawarah beberapa pihak yang menghasilkan konvensi dari UPK konvensional ke UPK Amanah Syariah untuk menghindari adanya riba. Kedua Jasa yang ditetapkan adalah 10% pertahun lebih rendah dari sebelumnya yaitu 18%. Praktik yang dilakukan pada saat ijab qabul menggunakan akad murabahah. Peminjaman dan pengembalian sesuai dengan emas pada akad.
Understanding identity construction of an in-service pre-k teacher using discursive psychology
Authors: Zakaria Faishal
Published: May 2023

Experts have asserted that teacher identity is an integral part of classroom practices; studying teacher identity construction would allow us to understand the teachers’ learning process and teaching practices. It is then argued that identity is fluid and is never a stand-alone aspect. Further, many studies of the discursive construction of teacher identities have suggested teacher identity construction is highly contextual. However, little research has focused on how pre-K teachers serving low-income students and families construct their professional identities discursively. Grounded within the perspectives of Discursive Psychology,  this study is interested in how a US government-sponsored pre-K program teacher discursively constructs her identities. The findings further suggest the fluidity of identity and particularly posit that the teacher has constructed and claimed her collective and co-constructed identities, as well as discursively formed her identities as a person who values social capital, who is practical, who serves the needy students and families, who has power or resources, and who is a lifelong learner. The findings further implicate the need to consider teachers’ identities to understand their learning, growth, and classroom practices.