bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Aromaterapi Lavender Terhadap Intensitas Nyeri Persalinan Kala 1 Di Desa Sungai Keledang Kota Samarinda Provinsi Kalimantan Timur
Authors: Lestari Shelvi Ovi , Rahmawati Renyta
Published: May 2024

Salah satu cara non-farmakologis untuk mengurangi nyeri persalinan yaitu dengan aromaterapi lavender. Penelitian ini bertujuan untuk mengetahui pengaruh aromaterapi lavender terhadap intensitas nyeri persalinan kala I di desa sungai keledang kota Samarinda Provinsi Kalimantan Timur.  Jenis penelitian ini Pre-Eksperimen dengan model rancangan One-Group Pretest-Posttest Design. Populasi dalam penelitian ini adalah semua ibu bersalin di PMB Siti Murtofiah A.Md Keb dan klinik Kusuma desa sungai keledang kota Samarinda Provinsi Kalimantan Timur. Sampel penelitian diambil dengan teknik Accidental Sampling sebanyak 30 sampel. Hasil analisis bivariat dengan uji statistik Wilxocon Signed Ranks pada batas kemaknaan α=0,05 diperoleh nilai ρ value =0,000 (ρ < 0,05) artinya terdapat pengaruh yang bermakna antara tingkat nyeri sebelum dan setelah diberikan aromaterapi lavender sehingga dapat disimpulkan ada pengaruh aromaterapi lavender terhadap intensitas nyeri persalinan kala I di di desa sungai keledang kota Samarinda Provinsi Kalimanta Timur. Diharapkan aromaterapi lavender dapat dijadikan sebagai alternatif non-farmakologi untuk mengurangi nyeri persalinan dan dapat diaplikasikan dalam pelayanan kebidanan maternitas.
Kajian Program CANGKAL Dalam Percepatan Penurunan Stunting Di Kampung Keluarga Berkualitas Puruk Cahu Seberang, Kabupaten Murung Raya
Authors: Yuliani Ni Nyoman Sri , Faradila Faradila , Suparyani Ni Ketut Adhi , Riduan Muhammad , Sari Rahmita
Published: May 2024

Kampung KB di Provinsi Kalimantan Tengah dilaksanakan dengan mengutamakan daerah yang masuk prioritas stunting termasuk Kabupaten Murung Raya yang prevalensi stuntingnya pada status merah yaitu 40,9 % tahun 2022. Kampung KB Puruk Cahu Seberang melaksanakan upaya percepatan penurunan stunting melalui Program kerja Puskesmas Puruk Cahu Seberang yaitu Program CANGKAL yang telah berhasil menurunkan angka stunting. Penelitian ini merupakan kajian praktik baik menggunakan cross sectional study dengan pendekatan kualitatif. Teknik pengumpulan data yaitu  data Primer diperoleh wawancara mendalam (in depth interview), Focus Group Disscusion  dan observasi kepada informan, observasi dan telaah dokumen. Analisis secara deskriptif  dan validitas data mengunakan triangulasi metode, triangulasi sumber dan triangulasi data. Pelaksanaan program CANGKAL berupa pendataan keluarga berisiko stunting,, audit kasus stunting di tingkat kabupaten, edukasi sosialisasi pengetahuan tentang risiko kesehatan stunting, gerebek stunting, bantuan sosial kepada keluarga sasaran stunting, dan praktik Dapur Sehat Atasi Stunting (DASHAT). Pengasuhan anak stunting secara berkala telah dilakukan berupa kunjungan secara langsung datang ke rumah KRS. Pendampingan terintegrasi pada anak remaja putri, ibu hamil, ibu bersalin dan ibu balita kegiatan Posyandu rutin setiap bulannya. Program CANGKAL memberikan dampak positif dalam penurunan angka stunting di Kampung KB Puruk Cahu Seberang. Namun terdapat beberapa faktor hambatan yang memerlukan perbaikan agar program ini dapat berjalan dengan optimal untuk dapat mempertahankan hasil pemulihan stunting.
Perbedaan EDTA Konvensional Dan EDTA Vacutainer Pada Pemeriksaan Kadar Hemoglobin
Authors: Hariyanto Hariyanto , Hermawati Andyanita Hanif , Prastama Hizkia Yustin
Published: May 2024

Penelitian ini bertujuan untuk mengevaluasi perbedaan hasil kadar hemoglobin yang diukur menggunakan EDTA Konvensional dan EDTA Vacutainer. Desain penelitian yang digunakan adalah pre-eksperimen, dengan total 30 sampel yang diambil dari populasi mahasiswi prodi TLM STIKes Hutama Abdi Husada Tulungagung. Hasil analisis menunjukkan rata-rata kadar hemoglobin menggunakan EDTA Konvensional sebesar 15.6 g/dL, sedangkan menggunakan EDTA Vacutainer sebesar 15.2 g/dL. Meskipun terdapat perbedaan, uji statistik menunjukkan bahwa perbedaan tersebut tidak signifikan secara statistik (p = 0.425). Kesimpulan dari penelitian ini adalah tidak ada perbedaan yang signifikan dalam hasil kadar hemoglobin antara penggunaan EDTA Konvensional dan EDTA Vacutainer. Namun, terdapat beberapa keterbatasan dalam penelitian ini, termasuk keterbatasan waktu pengambilan sampel dan adanya responden yang sedang menstruasi. Antikoagulan seperti EDTA digunakan untuk mencegah pembekuan sampel.
African Latin in Early Modern Thought: Language, Race, and Philology
Authors: Vozar Thomas Matthew
Published: May 2024

This article takes John Milton’s description of the “knotty Africanisms” of the Church Fathers as the launching point for an investigation of African Latin in early modern thought. The first part traces the development of a conception of Africitas or Africanismus as a peculiarly African form of Latin in Western scholarship from Erasmus to the early eighteenth century. The second part considers early modern African Latinists such as the Granada professor Juan Latino and the Jamaican poet Francis Williams and their reception in this light. The concept of Africitas is shown to have taken hold at the same time as the globalization of Latin.
The Prospects and Perils of Humanist Discourse
Authors: Martin Terence
Published: May 2024

The correspondence of Erasmus and Guillaume Budé represents an exemplary performance of the kind of intellectual exchange prized in humanistic circles of their day, though its sudden collapse has continued to puzzle interpreters. The design of this essay is to examine the prospects and perils of this epistolary venture set against the cultural, political, and religious circumstances of the time, and thus to show that this humanist project floundered not so much because of differences in personal character as due to fissures concealed in the rhetorical landscape over which these correspondents wished to travel. This rich and intricate theatre of humanist letters thereby illustrates both the noble aspirations and the inherent fragility of humanist discourse.
Teaching Aristotelian Ethics at the Racovian Academy: Considerations around Johann Crell’s Ethica Aristotelica
Authors: Laskowska Anna Maria
Published: May 2024

This article focuses on the Socinian ethical treatise Ethica Aristotelica, written by Johann Crell in c. 1622 in Raków, Poland. It is commonly believed that this work, which systematized the theory contained in Aristotle’s Nicomachean Ethics, was a simple compendium intended for exclusive use at the Racovian Academy, an educational institution that welcomed students of diverse religious backgrounds. However, a careful reading of the treatise shows that behind a veil of Aristotelian thought, controversial elements of the Socinian faith were smuggled into the text. These were primarily the idea of Pelagianism and the belief in the human nature of Christ. In the present article, a careful analysis accompanied by several lines of evidence support the idea thatEthica Aristotelica also represents an instrument for promoting the Socinian faith, initially among the students of the Academy, and then, with the print of the first edition in the Netherlands in 1650, among other European confessions.
Asuhan Keperawatan Defisit Pengetahuan Pada Lansia Diabetes Melitus Tipe II
Authors: Bille Silvirinus , Devi Hilda Mazarina
Published: May 2024

ABSTRACTIn general, many elderly people with Diabetes Mellitus (DM) do not know the signs and symptoms of the disease because of the lack of information received. The nursing problem of knowledge deficіt is the abѕence or lack of cognitive infοrmation related tο a particular tοpic. The aim of this study was to find out how nursinġ cаre is implemented for knowledge deficits in elderly patients with diabeteѕ mellitus type II (DMTII) at the Bаntur Health Centeг. The гesearch design used is a case study. The number of clients used is as much as 3 people with inclusion criterias they had never received health education and did not really understand the disease they were suffering from. The nursing problem raised is a knowledge deficit. The action given was an educational action on the correct 3J гules (amount, type and schedule) which was given in stages over 3 days using leaflets as media. After being given educаtion, there is an increase in the ability to explain topics regarding 3J, there is an improvement in behavior in implementing the 3J rules and the three patients can repeat some of the information that has been conveyed by the гesearcheг. Thuѕ it can be cοncluded that gradual health education affect knowledge level. It is recommended for family and nurses to support the patient in medication, diabeteѕ management education, and observation.
Perbedaan Tekanan Darah Lansia Laki-Laki Dan Perempuan Melalui Relaksasi Nafas Dalam
Authors: Doren M. Margaretha Gunu , Putri Ronasari Mahaji , Hilda Mazarina Devi
Published: May 2024

Jumlah penderita hipertensi pada lansia terus meningkat, perlu upaya menjaga tekanan darah lansia agar normal. Terapi relaksasi nafas dalam sebagai terapi yang dapat menurunkan tekanan darah. Tujuan penelitian yaitu membedakan tekanan darah lansia laki-laki dan perempuan melalui relaksasi nafas dalam di Posyandu Anggrek Desa Mulyo Agung Dusun Jetak Asri Kabupaten Malang. Desain penelitian pra-eksperimental berdesain pra-post-test two group. Populasi 40 lansia dengan sampel 32 lansia (16 lansia laki-laki dan 16 lansia perempuan)melalui accidental sampling. Variabel independen yakni relaksasi nafas dalam, variabel dependen tekanan darah. Instrumen berupa SOP relaksasi nafas dalam dan lembar observasi tekanan darah. Analisis data menggunakan marginal homogeneity. Hasil penelitian menunjukkan tekanan darah lansia laki-laki dan perempuan sebelum diberikan relaksasi nafas dalam berada pada kategori hipertensi stadium 2, sesudah diberikan relaksasi nafas dalam berada pada kategori hipertensi stadium 1, ada perbedaan tekanan darah lansia laki-laki dan perempuan melalui relaksasi nafas dalam dengan nilai masing-masing (p=0,000). Direkomendasikan bagi peneliti selanjutnya membandingkan terapi relaksasi nafas dalam dengan terapi lain serta mengemas relaksasi nafas dalam dengan lebih menarik.
The Effect of 12-Week Outward-Bound Training on Sports Attitude, Heart Rate and Physical Fitness Among College Students in China
Authors: Gao Jianxin , Abdullah Borhannudin Bin , Dev Roxana Dev Omar
Published: May 2024

Outward-bound training (OBT) originated in the UK as an outdoor survival method during World War II and is an experiential training course that emphasizes shaping teamwork, enhancing and strengthening individual psychological and athletic potential, and promoting organizational growth. However, OBT to improve sports attitude and physical fitness among college students remains unclear. The purpose of this study investigated the effect on sport attitude, heart rate and physical fitness among college students in China. Sixty college students (Aged 18-20, 19.05±0.85y) who were selected from Jiangxi Teachers College took part in this study. Participants were randomly assigned into two groups EG and CG. The EG completed 12 weeks OBT combined normal PE class intervention and the CG only for 12 weeks normal PE class intervention. The result indicated that the EG was statistically significant difference than control group after Paired-samples T test analysis for sports attitude questionnaire score (Male T=-11.515, P=0.001 and Female T=-23.070, P=0.001); HRMax (Male T=-5.755, P=0.001 and Female T=-4.007, P=0.001); HRAvg (Male T=-5.072, P=0.001 and Female T=-4.801, P=0.001); 50m run (Male T=8.085, P=0.001 and Female T=8.413, P=0.001); 800m run (Female T=5.949, P=0.001); 1000m run (Male T=3.722, P=0.001); Standing long jump (Male T=-2.233, P=0.042 and Female T=-5.824, P=0.001); Sit and reach (Male T=-3.872, P=0.002 and Female T=-5.274, P=0.001); Sit-up (Female T=-11.042, P=0.001 ); Pull-up (Male T=-4.276, P=0.001). Therefore, the conclusion suggested that 12-week OBT intervention was significant to improve sports attitude, heart rate and physical fitness among college students in China.
Evaluation of the rheological properties of stirred yogurt thickened with modified cassava (Manihot esculenta, Crantz) and taro (Colocasia sp.) starch
Authors: Ualema Nélio Jacinto Manuel , Muchanga Eufrasio Lubelio , Jeje Imaculada
Published: May 2024

This study aimed to assess the impact of modified cassava (Manihot esculenta Crantz) and taro (Colocasia sp.) starches on the rheological properties of homemade yogurt. Five treatments were tested: yogurt thickened with 0.5% (AM 0.5%) and 1% (AM 1%) cassava starch, yogurt thickened with 0.5% (AI 0.5%) and 1% (AI 1%) taro starch, and a control (yogurt without any thickener). The starches were subjected to physical modification and were incorporated into the yogurt, and then evaluated for rheological properties, apparent viscosity, texture, water retention capacity and syneresis. The result showed that the apparent viscosity was higher in yogurts produced with starches at all analysis speeds, however, the control treatment only showed significant differences with AM 0.5% and AI 0.5% (p<0.05). In the evaluation of firmness, syneresis, consistency coefficient (k), and flow index (n), yogurts made with starch exhibited the highest values, showing significant differences (p<0.05) compared to the control treatment. The water retention capacity (WHC) values ​​indicated significant differences between the control yogurt and the yogurt produced with thickeners, except AI 1% (p<0.05). For adhesiveness, no significant differences (p>0.05) were observed between starch and control treatments. The study concluded that modified cassava and taro starch improves the rheological properties of homemade yogurt, specifically in apparent viscosity, consistency, and firmness, and reduces the occurrence of syneresis.
Perfil epidemiológico dos óbitos por leucemia no Brasil nos anos de 2018 a 2023
Authors: Cruz Daniele Carvalho da , Fernando Sérgio Manuel Coelho , Paradis Rafael Joseph Macedo , Ribeiro Avive Carolina Brandão , Silva Ana Victoria Lima Passos da , Muniz Filho Carlos da Silva , Ferraz Beatriz Rodrigues , Azevedo Luiz Phillipe Silva , Gomes Maísa Hortência Passos , Prado Carla Azevedo , Araújo Malanny Santos
Published: May 2024

Introdução: As leucemias são neoplasias que afetam o tecido hematopoético. Estas neoplasias não possuem etiologia completamente conhecida, no entanto, sabe-se que estas estão relacionadas a um complexo conjunto de fatores, que incluem diversas mutações, infecções, exposição ambiental e hábitos de vida. As leucemias são classificadas de acordo com a linhagem celular afetada e quanto ao modo de evolução da doença. Este grupo diverso de neoplasias está relacionado a diversos óbitos anualmente, em todo o mundo. O objetivo deste estudo foi caracterizar epidemiologicamente os óbitos por leucemia registrados no Brasil durante o período de janeiro de 2018 a outubro de 2023. Metodologia: Para este estudo, foram coletados dados de mortalidade a partir do Departamento de Informática do Sistema Único de Saúde (DATASUS). Os dados foram tabulados e foi realizada a estatística descritiva. Foram consideradas as cinco regiões do país (norte, sul, centro-oeste, sudeste e nordeste), os sexos masculino e feminino, as faixas etárias de 0 a maiores de 80 anos e as raças/cor (branca, parda, preta, sem informação, amarela e indígena). Resultados: A partir da análise dos dados, observou-se que o maior número de óbitos se concentrou na região sudeste. Outros fatores como sexo masculino e maior faixa etária foram associados à maior mortalidade por leucemia. Quanto à avaliação das raças, observou-se mais óbitos entre os indivíduos brancos. Conclusão: É possível que as diferenças socioeconômicas presentes entre as diferentes regiões do país e raças tenham impacto quanto ao acesso aos serviços de saúde, ao diagnóstico e à notificação adequadas.
Folhas da mangueira (Mangifera indica L.) como potencial fonte de compostos bioativos no tratamento de doenças crônicas não transmissíveis: Uma revisão de literatura
Authors: Carvalho Jade Vitória Duarte de , Freires Sara Camila Vidal , Ferreira Paulo Henrique de Melo , Silva Sarah Emili Cruz da , Gomes Rafaela dos Santos , Nunes Letícia Rodrigues , Silva Amanda Vitória do Nascimento da
Published: May 2024

O objetivo deste estudo é investigar os efeitos dos compostos bioativos presentes nas folhas da mangueira (Mangifera indica L.) no tratamento das doenças crônicas não transmissíveis (DCNT) por meio de uma revisão bibliográfica da literatura de caráter narrativo, abordando os compostos bioativos encontrados nas folhas da mesma, e a relação do seu consumo na prevenção DCNT. A pesquisa foi realizada durante janeiro de 2024 a março de 2024 nas bases de dados online Scientific Electronic Library Online - SciELO, National Library of Medicine (PubMed) e Biblioteca Virtual em Saúde (BVS), cujo período de publicação se enquadram entre 2018 a 2024, na língua inglesa, textos disponíveis e completos. Os resultados revelaram que as folhas da mangueira contêm uma variedade de compostos bioativos incluindo compostos fenólicos como os polifenóis e flavonoides que demonstraram atividade antioxidante, antiinflamatória, anticarcinogênica, hipoglicemiante e hipolipemiante. Esses compostos foram associados à redução do estresse oxidativo, expressão de genes envolvidos na lipogênese na obesidade, inflamação e melhoria dos parâmetros metabólicos em estudos in vitro e em modelos animais, demonstrando a necessidade de mais estudos a respeito da temática e estudos in vivo para verificar outros possíveis efeitos.
Dexmedetomidina vs midazolam: Desfecho no pós-operatório do paciente idoso
Authors: Menezes Gabrielle Campos de , Almeida Lara Aladim , Nóbrega Maria Eduarda Galvão Xavier da , Moreira Vinícius Machado
Published: May 2024

Introdução: Em 2023, a Assembleia Mundial da Saúde organizada pela OMS comemorou o marco de aumento em 50% da média global da expectativa de vida. O impacto dessa transição demogŕafica no contexto médico e cirúrgico é expressivo, tendo em vista a necessidade de uma maior ponderação relacionada à maior sensibilidade de idosos a reações adversas no pós-operatório. Objetivo: Analisar o impacto do uso da medicação dexmedetomidina em detrimento do midazolam no desfecho pós operatório do paciente idoso. Metodologia:  Trata-se de uma revisão integrativa da literatura, incluindo 20 artigos publicados entre os anos de 2018 e 2023 nas plataformas PubMED, Lilacs, BVS e Google Acadêmico. Utilizou-se os descritores dexmedetomidine, midazolam, elderly, postoperative, combinados com o operador booleano “AND”. Resultados: A dexmedetomidina se destacou por meio de significativas vantagens em relação ao número de delirium pós operatório, agitação psicomotora, depressão respiratória, dor, qualidade do sono, necessidade de oxigênio, tremores e sedação residual. É válido dar ênfase à proteção da função cognitiva proporcionada aos pacientes idosos que fizeram o seu uso. Conclusão: A administração da dexmedetomidina como sedação intraoperatória evidenciou um menor índice de complicações pós-operatórias na população idosa quando comparada ao midazolam. Contudo, faz-se necessário a elaboração de novos estudos acerca dos efeitos dessas drogas em contextos isolados, sem comparativos com outras medicações, especificamente no cenário intra e pós-cirúrgico.
Episiotomia e complicações associadas: Uma revisão de literatura
Authors: Reis Júlia dos , Junqueira Larissa Silva , Azevedo Maria Júlia de Souza
Published: May 2024

Introdução: A episiotomia consiste em uma incisão cirúrgica perineal, região localizada entre a vagina e o ânus da mulher. A prática pode ser classificada de acordo com o local em que é feita: mediana, médio-lateral ou lateral. A incisão mediana consiste em um corte executado verticalmente a partir dos pequenos lábios em direção ao reto; na médio-lateral é executado um corte diagonalmente a partir do anel himenal. A técnica lateral, não é mais utilizada, pois provoca mais sangramentos e lesões. Objetivo: Este estudo visa avaliar a relação entre paridade e a episiotomia e as complicações associadas a essa prática. Métodos: Trata-se de uma revisão de literatura sistemática acerca da episiotomia e as complicações associadas à sua prática. Realizou-se um levantamento bibliográfico por meio de buscas eletrônicas nas seguintes bases de dados: Scientific Eletronic Library Online (SciELO), National Library of Medicine (PubMed) e Literatura Latino Americana em Ciências da Saúde (LILACS), no período de 2019 a 2023. Foram utilizados os descritores: Episiotomia, Gestação, Parto Normal. Resultados e Discussão: Na maioria dos artigos analisados, as principais indicações para episiotomia foram: primíparas, idade materna jovem, peso do recém-nascido superior a 4.000 gramas, distócia de ombro, recém-nascido com macrossomia fetal e feto com função cardíaca anormal. Conclusão: Elucida-se, portanto, que hodiernamente a episiotomia ainda é adotada como um procedimento de rotina, contrariando as evidências que invalidam as indicações para essa prática, já que, ultrapassa as taxas recomendadas pela Organização Mundial da Saúde (OMS), sendo realizadas sem critérios.
Prática na Terapia Intensiva Pediátrica frente as reações adversas de analgésicos e sedativos: Revisão integrativa
Authors: Papera Thamires da Silva , Martinez Elena Araujo , Martins Lohaine da Silva Chaves , Lima Bruna Santos Ferreira , Neves Déa Lúcia David , Souza Tania Vignuda de
Published: May 2024

Objetivo: analisar as evidências encontradas nas produções científicas nacionais e internacionais acerca da prática da equipe de saúde frente as reações adversas do uso de sedação e analgesia em UTIP. Metodologia: Revisão Integrativa de literatura, com a seguinte questão de busca: Qual é a prática da equipe de saúde frente as reações adversas do uso da sedação e analgesia na população pediátrica internada em UTIP? Após a leitura da íntegra dos artigos selecionados foi utilizada a análise temática segundo Minayo. Resultados: A revisão contou com 16 estudos e, após a leitura dos artigos selecionados foi realizada a análise temática do qual identificou-se três unidades temáticas, a saber: (1) riscos potenciais do uso prolongado de sedativos e analgésicos; (2) gestão e protocolos de analgesia e sedação utilizados pela equipe de saúde e; (3) o contexto de dor, sedação e abstinência na prática profissional na UTIP. Considerações finais: é preciso aumentar o conhecimento e treinamento continuado da equipe de saúde para melhorar a prática e a qualidade do cuidado. Além disso, é premente uma participação multidisciplinar, retirando a concentração do saber sobre esta temática nas mãos dos profissionais médicos e trazendo para todo os profissionais de saúde, especialmente das enfermeiras.
Desfechos pós correção cirúrgica e morbidade de pacientes com Gastrosquise e Onfalocele no Brasil, e a importância do papel da equipe multidisciplinar: Uma revisão integrativa
Authors: Gois Beatriz Vieira , Oliveira Halley Ferraro
Published: May 2024

Introdução: Os defeitos congênitos da parede abdominal, Gastrosquise e Onfalocele, tratam-se de herniações das vísceras e exposição destas no meio exterior. Em todos os casos, desde o seu diagnóstico, a reparação por via cirúrgica é sempre necessária, após todo o preparo da equipe, com a classificação destas quanto a complexidade e tamanho. E, assim, determinar o tipo de procedimento, amenizando os riscos que possam surgir. Posto com todas as cautelas, algumas complicações são inevitáveis, como demostrado na pesquisa a seguir, que enfatiza a necessidade de um cuidado ativo e assíduo com uma equipe multidisciplinar. Objetivos: O objetivo do presente estudo foi a realização de uma revisão integrativa sobre o prognóstico e morbidade após correção cirúrgica de pacientes com Gastrosquise e Onfalocele. Metodologia: A pesquisa foi baseada na estratégia PICO e os dados foram coletados em novembro de 2023. Empregando como descritores “Onfalocele Tratamento Cirúrgico”, “Gastrosquise Tratamento Cirúrgico”, “Gastrosquise e Onfalocele”. Nos critérios de inclusão estão as publicações em qualquer idioma e no período dos últimos dez anos. Resultados: 877 resultados foram obtidos, nas bases de dados do Google Acadêmico, Biblioteca Virtual em Saúde e Pubmed. Após análise minuciosa, foi realizada a exclusão de artigos que não atuavam nos critérios de elegibilidade, restando dessa forma, 11 estudos para serem detalhados. Conclusão: perante o exposto, há o detalhamento das principais morbidades e desfechos pós correção cirúrgica nos pacientes com Gastrosquise e Onfalocele, reafirmando a importância da equipe multidisciplinar na atuação em vigilância dos recém-nascidos acometidos.
Faktor yang Mempengaruhi Ibu Hamil Dalam Kunjungan Antenatal Care: Systematic Review and Meta-Analysis
Authors: Putri Aulia , Rahmadini Athifa , Wiliandari Anggia , Pradipta Yudi , Mayori Aurelia
Published: May 2024

Salah satu agenda utama SDGs adalah menurunkan angka kematian ibu dan kematian Bayi. Pemeriksaan antenatal yang berkualitas dan teratur selama kehamilan akan menentukan status kesehatan ibu hamil dan bayi yang dilahirkan. Tingginya AKI di Indonesia terutama disebabkan faktor ”Tiga terlambat” dan ”Empat terlalu”. Penyebab AKI di Indonesia bervariasi, antara lain: pendarahan pascapersalinan, infeksi nifas, dan komplikasi kehamilan. Angka Kematian Ibu (AKI) didunia berkisar diangka 303 per 100.000 kelahiran hidup dan Angka Kematian Bayi (AKB) didunia sebesar 41 per 100.000 kelahiran hidup (WHO, 2019). Hasil Long Form SP2020 menunjukkan Angka Kematian Ibu di Indonesia sebesar 189 yang artinya terdapat 189 kematian perempuan pada saat hamil, saat melahirkan atau masa nifas per 100.000 kelahiran hidup. Jika dibandingkan dengan Data Angka Kematian Ibu (AKI) Dinas Kesehatan Kabupaten Lima Puluh Kota tahun 2022 sebanyak 11 kasus dari 5.350 kelahiran hidup (205,6/100.000 KH), artinya terdapat 205-206 ibu meninggal dalam 100.000 jumlah kelahiran hidup, maka angka kematian ibu di Kabupaten Lima Puluh Kota Jauh lebih tinggi. Penelitian ini menggunakan systematic literature review dengan menggunakan metode PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analysis) melalui empat tahap, yaitu identifikasi, skrining, kelayakan dan hasil yang diterima. Penelitian bertujuan untuk menganalisi faktor-faktor yang mempengaruhi ibu hamil dalam kunjungan antenatal care yang dapat guna mengurangi angkat kematian ibu dan bayi. Penelusuran literatur dilakukan dengan cara mengakses database elektronik secara online dari Pubmed dan Google Scholar dengan melihat waktu publikasi dengan rentangan tahun 2019-2024. Framework yang digunakan adalah PICO. Berdasarkan 8 artikel yang telah di analisis, menunjukan bahwa ada hubungan tingkat pengetahuan ibu hamil, dukungan suami, aksebilitas pelayanan K4, paparan dan Media Informasi dengan kepatuhan melakukan Antenatal Care (ANC). Dari hasil analisis Systematic review dan meta analisis terdapat 8 artikel nasional maupun internasional didapatkan faktor yang mempengaruhi pemeriksaan Antenatal Care yaitu sebab kurangnya pengetahuan Ibu, sikap atau persepsi ibu, dan dukungan suami. Namun hubungan pekerjaan ibu tidak ada kaitannya. Seseorang akan sadar manfaat dan patuh dalam pengetahuan pemeriksaan kehamilan akan memberikan perilaku kesehatan yang baik.
Studi Kajian Literatur: Struktur Bawah Permukaan Menggunakan Metode Gaya Berat dibeberapa Daerah Indonesia
Authors: Agustina Tian , Muliddin  , Kasman
Published: May 2024

Untuk mengetahui situasi bawah permukaan daerah-daerah yang berada di Indonesia, berkaitan dengan hal tersebut maka dilakukan penelitian melalui pengkajian literature terhadap penelitian bawah permukaan dengan menggunakan metode gaya berat untuk beberapa daerah di Indonesia. Pemodelan struktur bawah permukaan di daerah kolaka utara dengan menggunakan metode gaya berat (Gravity) menunjukkan bahwa terdapat batuan intrusi yang diinterpretasikan sebagai formasi ofiolit dengan nilai densitas sebesar 3,07 mg/m3.Terdapat batuan dengan densitas besar yaitu mencapai 4,7 mg/m3 yang diprediksi sebagai batuan malihan berupa filit yang tersingkap hingga ke permukaan. Densitas rendah pada daerah Baratlaut yaitu 1,72 mg/m3 diinterpretasikan sebagai batu serpih. Densitas sedang dengan nilai antara 2,1-2,6 mg/m3 yang diinterpretasikan sebagai batuan pasir dan densitas 2,98 mg/m3 yang diinterpretasikan sebagai batuan kuarsit. Batuan dengan densitas relatif tinggi yaitu 3,6 mg/m3 yang diinterpretasikan sebagai basement. Berdasarkan hasil penelitian yang telah dilakukan, dapat ditarik kesimpulan bahwa struktur bawah permukaan di daerah Sekaran dan sekitarnya terdiri atas soil dengan densitas 1,33 gr/cm3, batuan lempung (clay) dengan densitas 2,49 gr/cm3, batuan pasir (sand) dengan densitas 2,02 gr/cm3, batuan andesit (andesite) dengan densitas 2,85 gr/cm3 dan batuan basal (basalt) dengan densitas 3,20 gr/cm3. Sedangkan Pemodelan struktur bawah permukaan daerah Jatibarang didominasi oleh batuan sedimen. Terdapat batuan pasiran di bagian tengah daerah penelitian, batuan lempung hingga kedalaman 200 m, batuan tufa hingga kedalaman 700 m serta batuan dasar. Kedalaman batuan dasar (basement) yang diperoleh adalah 500 m dengan kedalaman maksimal 1500 m serta terlihat adanya patahan yang terbentuk dan dapat menjadi perangkap hidrokarbon. Kemudian pemodelan yang telah dilakukan didaerah karangsambung, dapat disimpulkan bahwa pada pemodelan gaya berat ini, diduga sebagai terobosan dyke di peta slicing lintasan penampang AA1 berupa intrusi batuan beku basal (ρ = 3,03 g/cm3) dan lintasan penampang BB1 intrusi batuan andesit berupa (ρ = 2,48 g/cm3), serta tidak teridentifikasinya terobosan sill.
What do the papers say? The role of older adults in 20 years of digital inclusion debate in Dutch and Flemish newspapers
Authors: Van Leeuwen Cora , Jacobs An , Mariën Ilse , Vercruyssen Anina
Published: May 2024

Adoption of digital technology by older adults has become an important topic in academia and the public sphere within the debate on digital inclusion. Likewise, this topic has gained traction in the print media also. This paper assesses the representation of older adults in print media in the past 20 years in The Netherlands and Flanders. A total of 281 articles in the Dutch language were analysed to determine the representation of older adults and their level of agency. We found that they were represented in three manners: a) ambassadors of digital skill acquisition; b) naturally lacking in digital skills; or c) not alone in being helpless. These representations clearly increased during the COVIS-19 crisis. Some representations can be problematic, as the relationship between older adults and digital inclusion is not envisioned positively. Furthermore, they receive no agency to participate actively in the discussion surrounding their own digital inclusion and are too often used as the automatic example of the digitally illiterate – which is not particularly encouraging older adults towards digital skills acquisition.
Robotic exoskeleton-assisted walking rehabilitation for stroke patients: a bibliometric and visual analysis
Authors: Wen Shuangshuang , Huang Ruina , Liu Lu , Zheng Yan , Yu Hegao
Published: May 2024

Objective:

This study aimed to conduct a bibliometric analysis of the literature on exoskeleton robot assisted walking rehabilitation for stroke patients in the Web of Science Core Collection over the past decade.

Method:

Retrieved literature on exoskeleton robot assisted gait training for stroke hemiplegic patients from the Web of Science Core Collection from 1 January 2014 to 31 January 2024. The search method was topic search, and the types of documents were “article, meeting abstract, review article, early access.” CiteSpace was used to analyze the search results from countries, institutions, keywords, cited references and cited authors.

Result:

A total of 1,349 articles were retrieved, and 1,034 were ultimately included for visualization analysis. The annual publication volume showed an upward trend, with countries, institutions, and authors from Europe and America in a leading position. The core literature was also published by authors from European and American countries. The keywords were divided into 8 clusters: # 0 soft robotic exit, # 1 robot assisted gain training, # 2 multiple scales, # 3 magnetic rheological brake, # 4 test retest reliability, # 5 electromechanical assisted training, # 6 cerebra salary, and # 7 slow gain. The early research direction focused on the development of exoskeleton robots, verifying their reliability and feasibility. Later, the focus was on the combination of exoskeleton robot with machine learning and other technologies, rehabilitation costs, and patient quality of life.

Conclusion:

This study provides a visual display of the research status, development trends, and research hotspots, which helps researchers in this field to grasp the research hotspots and choose future research directions.
PCP auto count: a novel Fiji/ImageJ plug-in for automated quantification of planar cell polarity and cell counting
Authors: Stansak Kendra L. , Baum Luke D. , Ghosh Sumana , Thapa Punam , Vanga Vineel , Walters Bradley J.
Published: May 2024

Introdution: During development, planes of cells give rise to complex tissues and organs. The proper functioning of these tissues is critically dependent on proper inter- and intra-cellular spatial orientation, a feature known as planar cell polarity (PCP). To study the genetic and environmental factors affecting planar cell polarity, investigators must often manually measure cell orientations, which is a time-consuming endeavor. To automate cell counting and planar cell polarity data collection we developed a Fiji/ImageJ plug-in called PCP Auto Count (PCPA).

Methods: PCPA analyzes binary images and identifies “chunks” of white pixels that contain “caves” of infiltrated black pixels. For validation, inner ear sensory epithelia including cochleae and utricles from mice were immunostained for βII-spectrin and imaged with a confocal microscope. Images were preprocessed using existing Fiji functionality to enhance contrast, make binary, and reduce noise. An investigator rated PCPA cochlear hair cell angle measurements for accuracy using a one to five agreement scale. For utricle samples, PCPA derived measurements were directly compared against manually derived angle measurements and the concordance correlation coefficient (CCC) and Bland-Altman limits of agreement were calculated. PCPA was also tested against previously published images examining PCP in various tissues and across various species suggesting fairly broad utility.

Results: PCPA was able to recognize and count 99.81% of cochlear hair cells, and was able to obtain ideally accurate planar cell polarity measurements for at least 96% of hair cells. When allowing for a <10° deviation from “perfect” measurements, PCPA’s accuracy increased to 98%–100% for all users and across all samples. When PCPA’s measurements were compared with manual angle measurements for E17.5 utricles there was negligible bias (<0.5°), and a CCC of 0.999. Qualitative examination of example images of Drosophila ommatidia, mouse ependymal cells, and mouse radial progenitors revealed a high level of accuracy for PCPA across a variety of stains, tissue types, and species.

Discussion: Altogether, the data suggest that the PCPA plug-in suite is a robust and accurate tool for the automated collection of cell counts and PCP angle measurements.
Characteristics and prognostic value of cardiac magnetic resonance strain analysis in patients with different phenotypes of heart failure
Authors: Zhao Bianjie , Zhang Shiwen , Chen Liang , Xu Kai , Hou Yinglong , Han Shuguang
Published: May 2024

Background

Strain analysis of cardiac magnetic resonance imaging (CMR) is important for the prognosis of heart failure (HF). Herein, we aimed to identify the characteristics and prognostic value of strain analysis revealed by CMR in different HF phenotypes.

Methods

Participants with HF, including HF with reduced ejection fraction, HF with mildly reduced ejection fraction, and HF with preserved ejection fraction, and controls were enrolled. The baseline information and clinical parameters of participants were collected, and echocardiography and CMR examination were performed. Three-dimensional strain analysis was performed in the left ventricle, right ventricle, left atrium, and right atrium using CMR. A multifactor Cox risk proportional model was established to assess the influencing factors of cardiovascular adverse events in patients with HF.

Results

During a median follow-up of 999 days (range: 616–1334), 20.6% of participants (73/354) experienced adverse events (HF readmission and/or cardiovascular death). Univariable Cox regression revealed that a 1% increase in left atrial global longitudinal strain (LAGLS) was associated with a hazard ratio (HR) of 1.21 [95% confidence interval (CI):1.15–1.28; P < 0.001]. Left ventricular global circumferential strain (LVGCS) (HR, 1.18; 95% CI: 1.12–1.24; P < 0.001), and left ventricular global longitudinal strain (LVGLS) (HR, 1.27; 95% CI: 1.20–1.36; P < 0.001) were also associated with HF hospitalizations and cardiovascular deaths. Among clinical variables, hypertension (HR, 2.11; 95% CI: 1.33–13.36; P = 0.002), cardiomyopathy (HR, 2.26; 95% CI: 1.42–3.60; P < 0.001) were associated with outcomes in univariable analysis. Multivariable analyses revealed that LAGLS (95% CI: 1.08–1.29; P < 0.001), LVGLS (95% CI:1.08–1.29; P < 0.001) and LVGCS (95% CI: 1.19–1.51; P < 0.001) were significantly associated with outcomes. Among clinical variables, hypertension (95% CI: 1.09–3.73; P < 0.025) remained a risk factor.

Conclusion

CMR plays an obvious role in phenotyping HF. Strain analysis, particularly left atrial and left ventricular strain analysis (LAGLS, LVGLS, and LVGCS) has good value in predicting adverse outcome events.
Genetic tests as the strongest motivator of cooperation between participants and biobanks–Findings from cross-sectional study
Authors: Majchrowska Anita , Pawlikowski Jakub , Sak Jarosław , Świerczyńska Blanka , Suchodolska Magdalena
Published: May 2024

Introduction

The development of the scientific potential linked with biobanking and research on human biological material is highly dependent on the willingness of potential donors to cooperate with entities that collect the material. For this reason, it is crucial to identify the circumstances and factors that may encourage potential participants to donate their biological material. In particular, knowledge of the motivational factors that can be modified by the persons managing a biobank may prove notably important for shaping the organizational and communication policy of the biobank and other scientific institutions.

Material and methods

The research was carried out on a group of 1,100 people over 18 years of age representing the adult population of Poland in 2021.

Results

More than half of the respondents declared their willingness to donate a blood sample for research purposes to a biobank (57.8%). The most often indicated incentives among the factors supporting the donation of biological material were offers of: obtaining the results of genetic tests predicting the risk of diseases (77.1%), blood tests (71.3%), the possibility of obtaining a small remuneration (64.6%) and the carrying out of genetic ancestry tests (60.4%).

Conclusion

Offering the possibility of performing additional diagnostic tests, especially genetic tests, may significantly increase the willingness of potential donors to cooperate with biobanks and other entities collecting human biological material for the purpose of scientific research. However, attention should also be paid to the challenges and risks linked with respecting the privacy and autonomy of research participants.
Prenatal diagnosis of Silver–Russell syndrome with 8q12 deletion including the PLAG1 gene: a case report and review
Authors: Wu Ke , Zhu Yuying , Zhu Qiumin
Published: May 2024

Silver–Russell syndrome (SRS) is a clinically and genetically heterogeneous disorder. A retrospective analysis predicted that the live birth prevalence of SRS in Estonia is 1:15,886 [Yakoreva et al., Eur J Hum Genet, 2019, 27(11), 1649–1658]. The most common causative genetic mechanism in the proband is loss of paternal methylation in the imprinted control region 1 (ICR1) at 11p15.5 chromosome. A few studies suggested that inherited or de novo loss-of-function alterations of the PLAG1 gene, including the whole-gene deletion and intragenic pathogenic variants, could cause a rare type of SRS. To date, less than 20 unrelated PLAG1-related SRS cases have been reported, and the clinical information about these cases is limited. We report the first prenatal case of SRS with 8q12 deletion (including the PLAG1 gene). The fetus presented with intrauterine growth retardation, small for gestational age, relative macrocephaly at birth, and a protruding forehead. Unlike classical SRS cases, the fetus had micrognathia and did not show body asymmetry. We hope that the literature review in this study provides new insights into genotype–phenotype relationships of PLAG1-related SRS.
Granulocyte dynamics: a key player in the immune priming effects of crickets
Authors: Cho Youngwoo , Cho Saeyoull
Published: May 2024

This study investigates immune priming effects associated with granulocytes in crickets through a comprehensive analysis. Kaplan-Meier survival analysis reveals a significant contrast in survival rates, with the heat-killed Bacillus thuringiensis (Bt)-primed group exhibiting an impressive ~80% survival rate compared to the PBS buffer-primed group with only ~10% survival 60 hours post live Bt infection. Hemocyte analysis underscores elevated hemocyte counts, particularly in granulocytes of the killed Bt-primed group, suggesting a correlation between the heat-killed Bt priming and heightened immune activation. Microscopy techniques further explore granulocyte morphology, unveiling distinctive immune responses in the killed Bt-primed group characterized by prolonged immune activation, heightened granulocyte activity, phagocytosis, and extracellular trap formation, contributing to enhanced survival rates. In particular, after 24 hours of injecting live Bt, most granulocytes in the PBS buffer-primed group exhibited extracellular DNA trap cell death (ETosis), while in the killed Bt-primed group, the majority of granulocytes were observed to maintain highly activated extracellular traps, sustaining the immune response. Gene expression analysis supports these findings, revealing differential regulation of immune-related genes such as antibacterial humoral response, detection of bacterial lipopeptides, and cellular response to bacteria lipopeptides. Additionally, the heat-killed Bt-primed group, the heat-killed E. coli-primed group, and the PBS-primed group were re-injected with live Bt 2 and 9 days post priming. Two days later, only the PBS-primed group displayed low survival rates. After injecting live Bt 9 days later, the heat-killed E. coli-primed group surprisingly showed a similarly low survival rate, while the heat-killed Bt-primed group exhibited a high survival rate of ~60% after 60 hours, with actively moving and healthy crickets. In conclusion, this research provides valuable insights into both short-term and long-term immune priming effects in crickets, contributing to our understanding of invertebrate immunity with potential applications in public health.
Evaluation of the mechanistic basis for the antibacterial activity of ursolic acid against Staphylococcus aureus
Authors: Liu Guanhui , Qin Peng , Cheng Xinying , Wu Lifei , Zhao Wentao , Gao Wei
Published: May 2024

The antibiotics are generally regarded as the first choice approach to treat dairy mastitis, targeting the public health problems associated with the food safety and the emergence of antibioticresistant bacteria. The objective of the study was to evaluate the antibacterial efficacy of ursolic acid (UA) when used to treat Staphylococcus aureus and other isolates associated with bovine mastitis and to clarify the mechanistic basis for these effects. The bacteriostatic properties of UA extracted from Rosmarinus officinalis L. at four different purity levels were assessed by calculating minimum inhibitory concentration (MIC) values, while the synergistic effects of combining 98% UA with antibiotics were evaluated by measuring the fractional inhibitory concentration index (FICI). Changes in biofilm formation and the growth curves of the clinical isolates were assessed to clarify the bacteriostatic effect of UA. Furthermore, the cell wall integrity, protein synthesis, and reactive oxygen species (ROS) production were assessed to determine the antibacterial mechanism of UA treatment. Ultimately, UA was revealed to exhibit robust activity against Gram-positive bacteria including S. aureus (ATCC 25923), Streptococcus dysgalactiae (ATCC27957), Streptococcus agalactiae (ATCC13813), Enterococcus faecalis (ATCC29212), and Streptococcus mutans (ATCC25175). However, it did not affect Escherichia coli (ATCC 25922). The MIC values of UA preparations that were 98, 50, 30, and 10% pure against S. aureus were 39, 312, 625, and 625 μg/mL, respectively, whereas the corresponding MIC for E. coli was >5,000 μg/mL. The minimum bactericidal concentrations of 98% UA when used to treat three clinical S. aureus isolates (S4, S5, and S6) were 78, 78, and 156 μg/mL, respectively. Levels of biofilm formation for clinical S. aureus isolates decreased with increasing 98% UA concentrations. Above the MIC dose, UA treatment resulted in the dissolution of bacterial cell walls and membranes, with cells becoming irregularly shaped and exhibiting markedly impaired intracellular protein synthesis. S. aureus treated with 98% UA was able to rapidly promote intracellular ROS biogenesis. Together, these data highlight the promising utility of UA as a compound that can be used together with other antibiotics for the treatment of infections caused by S. aureus.
Recognition of facial emotion based on SOAR model
Authors: Ramzani Shahrestani Matin , Motamed Sara , Yamaghani Mohammadreza
Published: May 2024

Introduction

Expressing emotions play a special role in daily communication, and one of the most essential methods in detecting emotions is to detect facial emotional states. Therefore, one of the crucial aspects of the natural human–machine interaction is the recognition of facial expressions and the creation of feedback, according to the perceived emotion.

Methods

To implement each part of this model, two main steps have been introduced. The first step is reading the video and converting it to images and preprocessing on them. The next step is to use the combination of 3D convolutional neural network (3DCNN) and learning automata (LA) to classify and detect the rate of facial emotional recognition. The reason for choosing 3DCNN in our model is that no dimension is removed from the images, and considering the temporal information in dynamic images leads to more efficient and better classification. In addition, the training of the 3DCNN network in calculating the backpropagation error is adjusted by LA so that both the efficiency of the proposed model is increased, and the working memory part of the SOAR model can be implemented.

Results and discussion

Due to the importance of the topic, this article presents an efficient method for recognizing emotional states from facial images based on a mixed deep learning and cognitive model called SOAR. Among the objectives of the proposed model, it is possible to mention providing a model for learning the time order of frames in the movie and providing a model for better display of visual features, increasing the recognition rate. The accuracy of recognition rate of facial emotional states in the proposed model is 85.3%. To compare the effectiveness of the proposed model with other models, this model has been compared with competing models. By examining the results, we found that the proposed model has a better performance than other models.