bluuebunny/crossref_metadata_2025 huggingface dataset:
The Diabetic Lung Can Be Ameliorated by Citrullus colocynthis by Reducing Inflammation and Oxidative Stress in Rats with Type 1 Diabetes
Authors: Bejeshk Mohammad Abbas , Bagheri Fatemeh , Salimi Fouzieh , Rajizadeh Mohammad Amin
Published: July 2023

Background. Diabetes impacts various organs in the body and some reports showed that the lung is also affected by diabetes, and an imbalance of inflammation and oxidative stress may participate to diabetic lung impairments. The present study is conducted to assess the impacts of Citrullus colocynthis (CC) on some aspects of these impairments. Methods. Frothy two male Wistar rats (3‐4 months old and weighing 200–250 g) were used in the present research. Animals were divided into 3 groups of control, Diabetes, and Diabetes + Drug. CC was administered to diabetic rats orally. The lung tissue and BALF oxidative stress and inflammatory indices including the MDA, TAC, SOD, Gpx, TNFα, IL‐6, IL‐17, and IL‐10 were evaluated by the ELISA method. Results. Our observations disclosed the ameliorative impacts of CC administration against oxidative stress and inflammation imbalance. Also, it was found that CC improved body weight and fasting blood sugar in rats with diabetes. Conclusion. We can conclude that the administration of CC can be effective in improving diabetic lungs in rats.
Assessment of Food and Cooking Skills: Validation of a Portuguese Version of a Tool and Characterisation of Food and Cooking Skills in Young Adults
Authors: Costa Vânia , Borrego Rute , Mateus Cátia , Carolino Elisabete , Viegas Cláudia
Published: July 2023

Introduction: Food and cooking skills (FCSks) are defined as a complex, interrelated, and person-centred set of skills, necessary to provide and prepare safe, nutritious, and culturally acceptable meals for all members of the household. Recent studies have associated higher FCSk with healthier eating habits and better health. This study aimed to validate a Portuguese version of a tool to assess and describe FCSk in young adults. Methods: A cross-sectional study used an online anonymous questionnaire that was disseminated to students from three Portuguese Higher Education Institutes. The questionnaire validation included Cronbach alpha and confirmatory factor analysis (CFA). The Mann-Whitney test was used for evaluating sample differences and Pearson correlation for association among variables. Results: Internal consistency reliability was 0.89 for cooking skills (CSks) and 0.87 for food skills (FSks). A moderate positive correlation was found between CSks and FSks confidence (r = 0.658, p < 0.01). CFA presented a good adjustment model for most of the fit indices, indicating the adequacy of the questionnaire. The CSks score was 74.1 ± 21.2 (moderate) and the food Skills was 94.2 ± 20.8 (high). Cook pulses, steaming food, and planning meals ahead scored the lowest value, while boiling or simmering food, chopping, peeling vegetables, and reading the best-before date scored the highest value. No difference was found among sex (pCSk = 0.576; pFSk = 0.158), age (pCSk = 0.566; pFSk = 0.130), body mass index classes (pCSk = 0.903; pFSk = 0.320), or course (pCSk = 0.169; pFSk = 0.126). The greatest interest in gastronomy and frequency of meal preparation is associated with higher FCSk (p < 0.05). Conclusion: This research validated a Portuguese version of a tool to assess FCSk among young adults. Internal consistency reliability was adequate. Confirmatory factor analysis returned good psychometric properties for the questionnaire. Authors identified lower FCSk competencies in cooking pulses and vegetables, which are healthy and sustainable foods. This may compromise the adoption of healthy eating behaviours, so promoting FCSk in young adults may pose a strategy for nutrition and public health in reducing diet-related diseases. This tool may be used to identify opportunities for intervention in public health nutrition.
Cerebral Sinus Vein Thrombosis following Sneezing: Case Report
Authors: Nashef Helal , Haratz Salo , Mendel Rom
Published: July 2023

Cerebral sinus vein thrombosis (CVT) is a relatively rare neurovascular entity, usually associated with acquired or genetic hypercoagulable states, and in many cases it remains idiopathic. Trauma is also associated with CVT among patients with major head or neck trauma, including penetrating injuries. However, CVT associated with acceleration trauma has only been described in few cases so far. We present an unusual case of a 19-year-old woman with no past medical history, admitted with an extensive CVT following sneezing. A thorough investigation did not reveal any other potential etiology or risk factor other than estrogen-containing oral contraceptives. The patient was treated with anticoagulation and improved clinically with complete recanalization on follow-up imaging. This case suggests acceleration trauma may be a potential factor of risk for CVT.
Enrichment of Immune-Related Genes in Aggressive Primary Breast Angiosarcoma: A Case Report
Authors: Matsunuma Ryoichi , Sato Shoko , Chan Jason Yongsheng , Kinoshita Kazuo , Taku Keisei , Yamaguchi Kei , Hayami Ryosuke , Arai Kazumori , Suzuki Makoto , Tsuneizumi Michiko
Published: July 2023

Primary breast angiosarcoma is an extremely rare disease with a poor prognosis. Primary angiosarcoma is distinct from secondary angiosarcoma, which usually occurs in patients who have been previously treated for breast cancer. The low incidence of primary breast angiosarcoma has hindered the elucidation of its etiology and potential therapies. Here, we report a case of a patient with primary breast angiosarcoma who experienced recurrence after surgery. The tumor was refractory to systemic treatments, and the patient died 18 months after the surgery. We used RNA sequencing for gene expression profiling of the tumor. A high tumor inflammation signature score indicated enrichment in immune-related signaling. CIBERSORTx, a tool used to characterize the cellular composition of complex tissues based on gene expression, indicated that the immune cells in the tumor were predominantly macrophages, and this was confirmed using immunohistochemical analysis. These findings indicate the possible use of checkpoint immunotherapy for the treatment of primary breast angiosarcoma.
The First Systematic Meteorological Observations in the Americas (Recife, 1640–42)
Authors: Domínguez-Castro Fernando , Gallego María de la Cruz , Vaquero Jose M. , García Herrera Ricardo , Corral Victoria , Sáez Rosa M. Marina , Trigo Ricardo M. , Libonati Renata , Noguera Iván , El Kenawy Ahmed , Peña Angulo Dhais , Vicente-Serrano Sergio M.
Published: July 2023

In 1639, the German naturalist Georg Marcgraf established the first astronomical observatory in the Americas, located in Recife (Brazil). There, he made the first daily systematic meteorological observations of wind direction, precipitation, fog, and thunder and lightning from 1640 to 1642. We outline the circumstances that led to this observatory being established and analyze the observations. The range of values obtained from all the variables recorded by Marcgraf corresponds well with Recife’s current climate. However, wetter-than-normal conditions were recorded during 1640, while anomalous concentrations of foggy days occurred from May to December 1641. We hypothesize that these anomalous record foggy days could be associated with the highly explosive eruptions of the Komagatake and Parker volcanoes, both in 1640.
Efficacy of recombinant bovine basic fibroblast growth factor to reduce hemorrhage after cervical loop electrosurgical excision procedure
Authors: Weng Chongrong , Xu Jian , Yang Hua , Deng Panxia , Ou Honghui , Xu Yue , Zhuang Yuan , Nie Huilong
Published: July 2023

Objective

It has been reported that recombinant bovine basic fibroblast growth factor (rbFGF) may possess possible biological functions in promoting the process of wound healing. Consequently, our study aimed to investigate the hemostatic effect of topically applied rbFGF in patients who underwent a loop electrosurgical excision procedure (LEEP).

Methods

In this retrospective analysis, we meticulously examined clinicopathologic data from a cohort of 90 patients who underwent LEEP at our institution between 2020 and 2021. Subsequently, we conducted inquiries with the patients to ascertain the degree of vaginal bleeding experienced during the postoperative periods of 3 and 6 weeks, comparing it to their preoperative menstrual flow. The magnitude of the menstrual volume alteration was then quantified using a menstrual volume multiplier(MVM). The primary endpoints of our investigation were to assess the hemostatic effect of rbFGF by means of evaluating the MVM. Additionally, the secondary endpoints encompassed the assessment of treatment-related side effects of such as infection and dysmenorrhea.

Results

Our findings demonstrated a significant reduction in hemorrhage following cervical LEEP. Specifically, in the per-protocol analysis, the study group exhibited a statistically significantly decrease in MVM after 3 weeks (0 [0–0] vs. 1 [0–1], respectively; p < 0.001) and after 6 weeks (1 [1] vs. 2 [1–3], respectively; p < 0.001) of the procedure. No notable disparities were observed in the remaining outcomes between the two groups. Moreover, a logistic regression analysis was employed to explore the relationship between significant bleeding and rbFGF treatment (p < 0.001, OR = -2.47, 95% CI -4.07 ~-1.21), while controlling for confounding factors such as age, BMI, and surgical specimen.

Conclusions

In conclusion, our study findings highlight that the application of recombinant bovine basic fibroblast growth factorcan effectively mitigate hemorrhage subsequent to cervical loop electrosurgical excision procedure.
Oral to Nasal Endotracheal Tube Exchange: Modification to Enable Wider Applicability of an “Old Connector” Technique—A Case Report
Authors: Desilva Mahesh , Maan Ramneek , Helwany Muhammad Eyad , Bhuller Amardip S.
Published: July 2023

Nasotracheal intubation is an essential component of anesthetic management for intraoral and mandibular surgeries. Direct nasotracheal intubation can occasionally be difficult and require an initial oral endotracheal tube (ETT) placement with subsequent conversion to a nasal ETT. Numerous techniques have been described. However, execution can be challenging and limited by available resources. This report re-examines conventional oral to nasal ETT conversion techniques and describes another innovative approach utilizing equipment more readily available in the operating room or as an option when difficulty is encountered with conventional conversion techniques.
Retrace error calibration for interferometric measurements using an unknown optical system
Authors: Beisswanger R. , Pruss C. , Reichelt S.
Published: July 2023

In classical interferometric null test measurements, the measurement and reference beam path should be the same. A difference in the beam paths results in the so called retrace error. One very common approach to avoid retrace errors is to adapt the measurement wavefront to the reference wavefront with a computer generated hologram (CGH), which is costly and time consuming. A much more flexible approach is to do non nulltest measurement in combination with mathematical treatment of retrace errors. Most of such methods are based on iterative optimization or calibration of the nominal optical design of the interferometer. While this may be a convenient solution in the context of research, the more common use may be limited due to the need of the optical design of all interferometer components. In many cases, the optical designs of standard off the shelf optical assemblies are not available or disclosed by the manufacturer. This is especially true for transmission spheres of interferometers. We introduce the so called Black Box Model (BBM), used in the well known Tilted Wave Interferometry (TWI), as a mathematical model to account for retrace errors in interferometry. The Black Box Model is based on point characteristic functions which are adapted to the result and behavior of a real interferometer by calibration. With an extended calibration method, the need of a specific optical design of the interferometer is no longer necessary. Thus the method is attractive for a wide field of use in interferometry with standard off the shelf components.
Schooling of light reflecting fish
Authors: Pertzelan Assaf , Ariel Gil , Kiflawi Moshe
Published: July 2023

One of the hallmarks of the collective movement of large schools of pelagic fish are waves of shimmering flashes that propagate across the school, usually following an attack by a predator. Such flashes arise when sunlight is reflected off the specular (mirror-like) skin that characterizes many pelagic fishes, where it is otherwise thought to offer a means for camouflage in open waters. While it has been suggested that these ‘shimmering waves’ are a visual manifestation of the synchronized escape response of the fish, the phenomenon has been regarded only as an artifact of esthetic curiosity. In this study we apply agent-based simulations and deep learning techniques to show that, in fact, shimmering waves contain information on the behavioral dynamics of the school. Our analyses are based on a model that combines basic rules of collective motion and the propagation of light beams in the ocean, as they hit and reflect off the moving fish. We use the resulting reflection patterns to infer the essential dynamics and inter-individual interactions which are necessary to generate shimmering waves. Moreover, we show that light flashes observed by the school members themselves may extend the range at which information can be communicated across the school. Assuming that fish pay heed to this information, for example by entering an apprehensive state of reduced response-time, our analysis suggests that it can speed up the propagation of information across the school. Further still, we use an artificial neural network to show that light flashes are, on their own, indicative of the state and dynamics of the school, and are sufficient to infer the direction of attack and the shape of the school with high accuracy.
Aligned cellulose nanocrystal composite filament with high tensile strength enhanced by cationic polyacrylamide via flow focusing approach
Authors: Wang Yuda , Zhang Pinle , Guo Jinge , Zhong Ziyi , Li Wei , Liu Xinliang
Published: July 2023

Unsatisfactory macroscopic strength is one of the important reasons that limit the application of cellulose composites. However, the mechanical properties of cellulose composites could be improved by the directional orientation of cellulose nanofibers. In this paper, a five-channel microfluidic chip was designed to fabricate core-sheath cellulose nanocrystal/ cationic polyacrylamide (CNC/CPAM) composite filament. The core spinning solution with high flow velocity promoted the extended arrangement of CPAM in sheath flow. CPAM with long chain structure could not only reduce the electrostatic repulsion between CNCs, but also ensures the fiber orientation by inhibiting the disorderly diffusion of CNCs, thus improving the toughness of the composite filament. The orientation of the composite fiber was studied by wide-angle X-ray scattering, showing an orientation index of 0.725. The mechanical properties of the composite fiber were tested by a universal material testing machine. The tensile strength was 510 ± 20 MPa, which was about 117% higher than that of pure CNC spun fiber, and the elongation at break was also increased by about 70%. The improvement in mechanical properties was attributed to the increase in the content of intramolecular and intermolecular hydrogen bonds. In addition, the demonstrated spinning technology provided a new way for preparing high-performance composite fibers.
A community-based cross-sectional study of COVID-19 and psychological distress using the impact of event scale revised among recovered patients of COVID-19
Authors: Mushtaq Beenish , Jan Yasmeen , Bhat Ashfaq Ahmad , Deeba Farah
Published: July 2023

COVID-19 infection is a potentially traumatic experience in terms of the risk of running a Severe Acute Respiratory Syndrome in addition to the social implications of the disease in terms of being isolated and follow up of strict quarantine measures of close contact. The purpose of this study was to assess the prevalence of psychological distress and its risk factors in patients who develop COVID-19 infection. There is scanty evidence regarding the magnitude of COVID-19-related psychological distress (PD) among the general population of India, and Post Traumatic Stress Disorder (PTSD) is a Mental Disorder that develops after a traumatic event that has a life-threatening impact.

The aim of this study was to assess COVID-19 infection.

Material and methods: This study was conducted among 672 COVID-19 survivors of district Budgam from (March to August 2020). They were contacted by telephone, and psychological distress in the post-COVID recovery period was assessed using the IES-R scale. This is a 22-item scale, and each item is rated on a scale ranging from 0-4. Suitable Statistical Analysis was done to analyze risk factors for the development of any psychological distress.

Methods: Descriptive cross-sectional study.

Study design: Cross-sectional study from District Budgam of Kashmir Division.

Study tool: using the IES-R scale for PTSD.

Result: In our study prevalence of psychological distress using IES –R was mild in (7.08 %) of the study participants and moderate in (1.06 %) of the study participants. Psychological distress in study participants was examined by age, sex, employment status, family history, COVID-19 disease status and history of hospitalization. No statistical significance between age, gender, days of hospitalization and PTSD was seen. However, statistical significance with the IES–R score was seen between family history and the presence and absence of symptoms in the study subjects.

Conclusion: As the pandemic crisis seems to be ebbing, the current findings help us to identify risk factors and devise pragmatic strategies to curtail the burden of mental issues and successfully meet the challenges that follow the pandemic
Квалификация неоконченного преступления
Authors: Жувак Е.Д , Безуглый С.Н
Published: July 2023

Научная статья посвящена рассмотрению проблем квалификации неоконченного преступления. В статье проанализированы особенности квалификации преступлений в форме приготовления к преступлению и покушения на преступление. Отмечены некоторые проблемы квалификации неоконченных форм преступлений.
Бюрократия как принцип организации и функционирования аппарата государства
Authors: Кладченко Д.Д.
Published: July 2023

Бюрократия дает возможность управлять большой и сложной организацией. Наличие надзорных или вышестоящих органов помогает клиентам или гражданам подавать апелляции и жалобы тогда, когда их не устраивает работа нижнего звена. Без неѐ государство не сможет выполнять свои основные функции. Аспект бюрократии общеизвестен человечеству с незапамятных времен, поскольку с бюрократией неразрывно связано само государство. Следует подчеркнуть, практическую значимость исследования данной проблемы, поскольку принцип бюрократии является одним из известнейших принципов организации государственного аппарата, то без знания и понимания его сущности сложно отыскать более оптимальный способ управления государством.¬¬¬ ¬ Бюрократия необходима в любой социальной системе. Противоречие состоит в том, что именно современная бюрократия, которая действует вопреки общегосударственным и общенациональным интересам, нужна для того, чтобы выполнить одну из решающих ролей в возрождении и укреплении российского государства. В других странах на различных этапах развития, когда высшие государственные учреждения не пользуются доверием и поддержкой населения, а легитимность государственной власти проблематична, бюрократия решает многие задачи чрезвычайного характера, которые стоят перед страной, переживающей системный кризис.
Reflexiones sobre el papel del profesional de la salud-profesor en la educación en áreas de la salud
Authors: Sánchez-Corredor Cristhiam David , Rubio-Romero Jorge Andrés
Published: July 2023

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Biological properties and symbiotic relationships of human bifidobacteria
Authors:   Veltischev Research and Clinical Institute for Pediatrics and Pediatric Surgery, Pirogov Russian National Research Medical University, Moscow, Russian Federation, Khavkin A.I. , Bukharin O.V. ,   Institute of Cellular and Intracellular Symbiosis, Ural Branch of the Russian Academy of Sciences, a separate structural subdivision of the Orenburg Federal Research Center, Ural Branch of the Russian Academy of Sciences, Orenburg, Russian Federation, Perunova N.B. ,   Institute of Cellular and Intracellular Symbiosis, Ural Branch of the Russian Academy of Sciences, a separate structural subdivision of the Orenburg Federal Research Center, Ural Branch of the Russian Academy of Sciences, Orenburg, Russian Federation, Ivanova E.V. ,   Institute of Cellular and Intracellular Symbiosis, Ural Branch of the Russian Academy of Sciences, a separate structural subdivision of the Orenburg Federal Research Center, Ural Branch of the Russian Academy of Sciences, Orenburg, Russian Federation, Sitkin S.I. ,   Almazov National Medical Research Centre, Saint Petersburg, Russian Federation,   I.I.Mechnikov North-Western State Medical University, Saint Petersburg, Russian Federation
Published: July 2023

Bifidobacteria, despite more than a century of research history, attract the attention of researchers. Currently, more than 100 species of the Bifidobacterium genus, belonging to the Actinomycetota phylum, have been described. An analysis of the biological properties of bifidobacteria during the formation of symbiotic relationships with the human host revealed several functional clusters, among which one group of bifidobacteria is involved in the cytokine balance, the second recognizes microsymbionts, protecting the biotope from pathogens, and the third supports the barrier function of enterocytes and colonocytes. This ensures optimal functioning of the intestinal biotope. The proven properties of bifidobacteria expand the range of their clinical use as new biological products and functional foods for dysbiosis correction, considering the physiological "specialization" of various Bifidobacterium strains. Key words: Bifidobacterium, Actinomycetota phylum, intestinal microbiome, dysbiosis, probiotics, functional foods
Acute viral gastroenteritis: a brief review of current research and experience with antiviral drugs based on technologically processed antibodies
Authors:   Regional Clinical Emergency Hospital, Barnaul, Russian Federation, Filippova G.M. , Morozova O.P. ,   Altai State Medical University, Barnaul, Russian Federation, Kirichek E.Yu. ,   Altai State Medical University, Barnaul, Russian Federation, Eliseeva A.A. ,   Regional Clinical Emergency Hospital, Barnaul, Russian Federation, Efimenko O.E. ,   Regional Clinical Emergency Hospital, Barnaul, Russian Federation, Raba T.I. ,   V.Ignatenko Municipal Children's Clinical Hospital of the Nicolae Testemicianu State Medical and Pharmaceutical University, Chisinau, Republic of Moldova, Raupov F.O. ,   Republican Educational and Clinical Center of Family Medicine, Dushanbe, Republic of Tajikistan,   Scientific Research Institute of Preventive Medicine of Tajikistan, Dushanbe, Republic of Tajikistan, Kulieva Z.M. ,   A.Aliyev Azerbaijan State Institute of Advanced Medical Training, Baku, Republic of Azerbaijan, Eyvazov T.G. ,   A.Aliyev Azerbaijan State Institute of Advanced Medical Training, Baku, Republic of Azerbaijan
Published: July 2023

This article discusses the problem of acute viral gastroenteritis (AVGE), including aspects of immunopathogenesis that are significant for effective therapy and prevention. It also summarizes the results of randomized clinical trials assessing the efficacy of technologically processed purified antibodies (Anaferon® for children, Ergoferon®). We describe our own experience with Ergoferon® evaluated in a an open-label study involving 94 AVGE patients aged 1 to 10 years. Children who received Ergoferon® demonstrated rapid resolution of symptoms and normalization of body temperature 3–3.5 days after treatment initiation. Resolution of vomiting was achieved during the first 2 days of therapy in most of the patients. Median duration of diarrhea was 3.5–4 days, with a trend to a little bit longer diarrhea period in patients in patients aged 1–3 years. None of the patients developed complications or aggravation by the moment of discharge from the hospital (day 5–6 of treatment); all children were cured. The therapy was well tolerated by patients; none of them reported adverse events. Our findings suggest that drugs based on technologically processed affine purified antibodies are effective are effective and can be used in comprehensive treatment for acute viral gastroenteritis in children to ensure active defense against viruses, support the immune system, and alleviate symptoms via the anti-inflammatory effect. Key words: acute viral gastroenteritis, Ergoferon, Anaferon for children, treatment
An Adaptive Fuzzy Control Method for Multi-joint Manipulator Based on Fuzzy Compensation
Authors: Zhang Biao , Yang Baoping , Wang Qiong
Published: July 2023

The manipulator is an important machine for assisting production and life and has been widely used in various fields. Aiming at the problem that the manipulator control system cannot realize fast and high precision trajectory tracking control when it is disturbed by random and non-linear factors, considering that the data information of the fuzzy system is known and the control variables of the system can be controlled and measured, an adaptive fuzzy control law based on fuzzy compensation is designed by using the approximation characteristics of the fuzzy system. This method can effectively suppress the external disturbance and friction disturbance in the process of manipulator motion, so that it can quickly and accurately track the position and speed of the manipulator. The simulation results of the proposed adaptive robust control method based on fuzzy compensation show that it can well suppress the influence of non-linear factors such as friction, disturbance and load variation, and improve the position tracking accuracy by 64.5% and the speed tracking accuracy by 67.3%.
Isolation and characterization of lytic bacteriophages infecting Pectobacterium atrosepticum
Authors: Wu Jian , Handique Utpal
Published: July 2023

Pectobacterium spp. cause blackleg and soft rot on potato worldwide. Potato is a staple crop in China, and blackleg and soft rot diseases caused by Pectobacterium spp. have increased significantly as potato cultivation expanded rapidly in the last decade. This study was conducted to isolate and characterize the lytic bacteriophages infecting the major pathogen causing potato blackleg and soft rot, Pectobacterium atrosepticum (P. a.), in water and soil samples collected in the cities Wuhan and Datong in China. Three lytic bacteriophages were obtained and named Pectobacterium Phages ZRIMU1, 2, and 7. Transmission electron microscopic analysis revealed that all three phages were similar in size, with a smooth head (diameter ca. 40–50 nm) and without a neck or tail. The adsorption of phages PP1, PP2, and PP7 to P. a. after 18, 27, and 18 min was 98, 99 and 98%, respectively. The latent periods for PP1, PP2, and PP7 were 20, 40, and 50 min, respectively. In vitro bacterial challenge assays showed that these three phages were able to infect P. a. 1 h after coinoculation. The potential of these bacteriophages to protect potato seedlings was tested. After 27 days of inoculation, seedlings inoculated with water and sprayed with or without phages developed well, and no symptoms developed. Seedlings inoculated with P. a. only had a significantly lower survival rate than the controls, and seedlings coinoculated with P. a. and phages significantly improved the survival rate by 40%. Recovery of symptomatic plants was observed in groups that were treated with either a single phage or a mixture of phages. More investigations are needed to clarify the mechanism by which phages can be used to cure symptomatic potato plants.
Identification of genetic loci and candidate genes underlying freezing tolerance in wheat seedlings
Authors: Pan Xu , Nie Xianlai , Gao Wei , Yan Shengnan , Feng Hansheng , Cao Jiajia , Lu Jie , Shao Hui , Ma Chuanxi , Chang Cheng , Zhang Haiping
Published: July 2023

Frost damage restricts wheat growth, development, and geographical distribution. However, the genetic mechanism of freezing tolerance (FT) remains unclear. Here, we evaluated FT phenotypes of 245 wheat varieties (lines) and genotyped them using a Wheat 90K array. The association analysis showed that ten stable loci were significantly associated with FT (P < 1 × 10-4), and explained 6.45-26.33% of the phenotypic variation. In particular, the major locus QFT.ahau-7B.2 was consistently related to all nine sets of FT phenotypic data. Based on five cleaved amplified polymorphic sequence (CAPS) markers closely linked to QFT.ahau-7B.2, we narrowed down the target region to the 566.13-566.63 Mb interval on chromosome 7B, in which four candidate genes were annotated. Of these, only TaRPM1-7BL exhibited consistent differential expression after low temperature treatment between freezing-tolerant and freezing-sensitive varieties. The results of cloning and whole-exome capture sequencing indicated that there were two main haplotypes for TaRPM1-7BL, including freezing-tolerant Hap1 and freezing-sensitive Hap2. Based on the representative SNP (+2556, A/G), leading to an amino acid change in the NBS domain, a CAPS marker (CAPS-TaRPM1-7BL) was developed and validated in 431 wheat varieties (lines) and 318 F2 lines derived from the cross of ‘Annong 9267’ (freezing-tolerant) × ‘Yumai 9’ (freezing-sensitive). Subsequently, the TaRPM1-7BL gene was silenced in ‘Yumai 9’ by virus-induced gene silencing (VIGS), and these silenced wheat seedlings exhibited enhanced FT phenotypes, suggesting that TaRPM1-7BL negatively regulates FT. These findings are valuable for understanding the complex genetic basis of FT in wheat.
The effect of social anxiety on prosocial behavior of college students: the mediating role of interpersonal security and the moderating role of basic psychological need satisfaction
Authors: Li Qiangqiang , Li Na
Published: July 2023

Background
The purpose of this study was to examine the impact of social anxiety on prosocial behavior and the role of interpersonal trust and basic psychological needs satisfaction in it.
Methods
The study utilizes a questionnaire (N = 458) to investigate the impact of social anxiety on prosocial behavior, as well as the mediating role of interpersonal security and the moderating role of basic psychological needs satisfaction.
Results
(1) the level of social anxiety negatively predicts prosocial behavior; (2) interpersonal security mediates the impact of social anxiety on prosocial behavior, as higher levels of social anxiety reduce interpersonal security, thereby decreasing prosocial behavior, (3) In the context of the negative prediction of social anxiety on prosocial behavior, the basic psychological needs satisfaction plays a moderating role. When an individual's level of satisfaction with basic psychological needs is low, the negative impact of social anxiety on prosocial behavior is significantly enhanced.
Conclusion
These findings reveal a relationship between social anxiety and pro-social behavior and provide strategies for socially anxious individuals to improve prosocial behavior.
Blackcurrant extract promotes the differentiation of MC3T3-E1 pre-osteoblasts
Authors: Nanashima Naoki , Horie Kayo , Oey Indrawati
Published: July 2023

Background
The risk of developing osteoporosis in menopausal women increases as estrogen secretion decreases. Blackcurrant extract (BCE) has been reported to ameliorate osteoporosis; however, the mechanisms underlying this phenomenon are unclear. Furthermore, although BCE has phytoestrogenic activity, its effects on osteoblasts are unknown. In this study, mouse pre-osteoblast MC3T3-E1 cells were used to investigate BCE-mediated attenuation of osteoporosis, with a focus on osteogenesis.
Methods and Results
After treating MC3T3-E1 cells with BCE for 48 h, the total number of cells was counted, and no conspicuous differences were observed. The levels of osteoblast differentiation markers, alkaline phosphatase activity, and total collagen content increased in BCE-treated cells on days 3–14. Additionally, the expression of genes encoding osteoblast differentiation markers, including collagen type I, alkaline phosphatase, osteocalcin, and runt-related transcription factor 2, increased in BCE-treated cells. At 21 days of treatment, calcified nodule levels were increased.
Conclusions
These findings show that BCE may promote osteogenesis by inducing osteoblast differentiation.
A Systematic Review and Meta-Analysis of the Consequences of Adolescent Pregnancy on Maternal and Neonatal Health
Authors: Islam Md Shahedul , Chowdhury Akibul Islam , Akhter Kazi Turjaun , Islam Md. Sayedul , Halima Oumma
Published: July 2023

Aims: Globally, both Human Nutritionists and Public Health Professionals are concerned about adolescent pregnancy. Maternal and neonatal morbidity and mortality are much greater among adolescent mothers than among adult mothers. This systematic review aimed to examine the effects of teenage pregnancy on Maternal and Neonate Health Status.
Methods: Three electronic databases (PubMed, the Cochrane library, and Google Scholar) were scoured for relevant articles between January 2015 and October 2021. All of the included studies were assessed for their methodological quality using the Joint Biomedical Investigations Handbook's (JBI) standards. To estimate the pooled outcomes, a random-effects model was applied.
Result: After examining the eligibility criteria, twelve papers were assessed for qualitative evaluation, and eight were selected for quantitative analysis. The pooled result of the analysis showed that the risk of preeclampsia [Odd (95% CI): 1.02 (0.79-1.32)] and anemia [Odd (95% CI): 1.11 (0.97-1.27)] was higher, and the risk of gestational diabetes [Odd (95% CI): 0.76 (0.51-1.13)], placental disruption [Odd (95% CI): 0.89 (0.5-1.56)], cesarean delivery [Odd (95% CI): 0.88 (0.51-1.52)] and premature rupture of the fetal membrane [Odd (95% CI): 0.95 (0.69-1.3)] were lower among adolescent mother compared with adult mother. Nevertheless, no significant differences existed across the groups. Adolescents had a significantly higher risk of having a premature baby [odds ratio (95% CI): 1.72, (1.03-2.85)]. whereas there is no significant difference observed in the risk of low birth weight and postpartum hemorrhage.
Conclusion: The current meta-analysis suggests that adolescent pregnancy might have a potential effect on maternal and neonatal health.
Geology from hand to hand (to the 85th anniversary of the Professor Aleksey Ivanovich Trubachev)
Authors: Korolkov A. T.
Published: July 2023

This article is devoted to the Professor Aleksey Ivanovich Trubachev who is one of the most famous graduates of the Irkutsk Polytechnic Institute (now Irkutsk National Research Technical University), and his role in the formation  of a young geologist. Summarized published materials of the author of the article and his memoirs were transformed into  an essay on the life and creative activity of Aleksey Ivanovich Trubachev. Immediately after the graduation, he was sent to Trans-Baikal Integrated Research University (Chita) and joined a group of researchers investigating the unique Udokan deposit of copper sandstones and shales, which was headed by a well-known scientist, Deputy Director of the Institute Leonid Frantsevich Narkelyun. The largest works of A.I. Trubachev deal with the study of the material composition of the Udokan deposit ore bodies, the results of which are reflected in his candidate's dissertation defended at the Irkutsk Polytechnic University and in his doctoral dissertation defended in Novosibirsk. In all his works A.I. Trubachev proved the primary sedimentary genesis of the stratiform ores of the Udokan deposit, which was confirmed by the results of detailed exploration. In 1974, he started his teaching career. Today Aleksey Ivanovich is a professor at the Department of Minerals and Secondary Raw Materials Processing at the Trans-Baikal State University. For the period of his professional career, he has published 376 works, including 18 monographs, 19 teaching aids and textbooks on mineralogy, petrography and industrial mineralogy. A.I. Trubachev is actively involved in the creation of the unique mineralogical museum at the TransBaikal State University. The article pays special attention to the role of A.I. Trubachev in the formation of a young geologist during field works at the Udokan deposit. Field production practice is a major in the formation of a young geologist. In this case the most important things are the trust of the field mentor and early independent routing. Geologists and scientists like Professor A.I. Trubachev with extensive field and pedagogical experience certainly belong to the golden fund of the scientific and pedagogical personnel of Siberia.
Post and During SARS-Cov-2 Syndrome in Children
Authors: Karimi Afshar Niloofar , Sinaei Reza , Hoseininasab Ali , Parvaresh Saeedeh , Ahmadipour Maryam , Karami Robati Fatemeh , Jafari Maedeh , Jalali Sedigheh , Jafari Mohammad Ali
Published: July 2023

Background:

SARS-Cov-2 is a highly infectious and contagious disease caused by a co-ronavirus called severe coronavirus-acute respiratory syndrome (SARS-CoV2). Children with SARS-CoV-2 infection are often asymptomatic or have relatively mild symptoms, often with cough and fever. Today, despite High value information about the manifestations and risk factors for SARS-CoV-2, there is limited information on post-SARS-Cov-2 syndrome, especially in children.

Objective:

This study aimed to evaluate the symptoms of SARS-Cov-2 syndrome in children with SARS-Cov-2 in Afzalipour Hospital in Kerman.

Methods:

The present descriptive cross-sectional study was performed on 122 children with SARS-Cov-2 in 2020-2021. A checklist including information on age, sex, duration of hospitalization, need for admission in intensive care units, clinical symptoms, mortality during or after discharge, underlying illness, and need for readmission was completed by reviewing patient records and inter-views. The collected information was entered into SPSS software version 26 for statistical analysis.

Results:

The mean age of patients was 46.64±40.39 months. 49.2% of patients were female and 50.8% were male. The most common symptoms were fever (84.4%), weakness (49.2%), cough (34.4%), nausea/vomiting (34.4%), dyspnea (27%), and diarrhea (26.2%). In 122 children, 115 children (94.3%) had symptoms for less than one month, one child had symptoms for one to two months, and 6 children (4.9%) had symptoms for a long duration (more than two months). The most common clinical signs in children with post-SARS-Cov-2 syndrome were weakness (33.3%) and dyspnea (33.3%).

Conclusion:

Persistent symptoms of post-SARS-Cov-2 syndrome are less common in children with SARS-Cov-2 disease in Iran.
Network Analysis Using the Established Database (K-herb Network) on Herbal Medicines Used in Clinical Research on Heart Failure
Authors: Park Subin , Kim Ye-ji , Bae Gi-Sang , Kim Cheol-Hyun , Youn Inae , Leem Jungtae , Chu Hongmin
Published: July 2023

Objectives: Heart failure is a chronic disease with increasing prevalence rates despite advancements in medical technology. Korean medicine utilizes herbal prescriptions to treat heart failure, but little is known about the specific herbal medicines comprising the network of herbal prescriptions for heart failure. This study proposes a novel methodology that can efficiently develop prescriptions and facilitate experimental research on heart failure by utilizing existing databases.Methods: Herbal medicine prescriptions for heart failure were identified through a PubMed search and compiled into a Google Sheet database. NetMiner 4 was used for network analysis, and the individual networks were classified according to the herbal medicine classification system to identify trends. K-HERB NETWORK was utilized to derive related prescriptions.Results: Network analysis of heart failure prescriptions and herbal medicines using NetMiner 4 produced 16 individual networks. Uhwangcheongsim-won (牛黃淸心元), Gamiondam-tang (加味溫膽湯), Bangpungtongseong-san (防風通聖散), and Bunsimgi-eum (分心氣飮) were identified as prescriptions with high similarity in the entire network. A total of 16 individual networks utilized K-HERB NETWORK to present prescriptions that were most similar to existing prescriptions. The results provide 1) an indication of existing prescriptions with potential for use to treat heart failure and 2) a basis for developing new prescriptions for heart failure treatment.Conclusion: The proposed methodology presents an efficient approach to developing new heart failure prescriptions and facilitating experimental research. This study highlights the potential of network pharmacology methodology and its possible applications in other diseases. Further studies on network pharmacology methodology are recommended.
Hepatic/Renal Safety Evaluation of Cheongsimyeonja-tang (Qīngxīn Liánzǎo Tāng), Dodam-tang (Táodàn Tāng), Hyeolbuchukso-tang (Xuè Fǔ Zhú Yū Tāng), and Boshiniknai-tang (Bǔ Shèn Yì Nǎo Tāng) for Cerebrovascular Diseases: A Retrospective Study
Authors: Kim Min-hwa , Cho Im-hak , Nam I-rang , Kim Maria , Ku Ki-beom , Lee Se-yeon , Kwon Jung-nam , Lee In , Hong Jin-woo , Yun Young-ju , Kim So-yeon , Han Chang-woo , Park So-jung , Choi Jun-yong , Shin Hyeun-kyoo
Published: July 2023

Objectives: As Korea transitions into an aging society, the incidence of cerebrovascular disease is expected to increase. Herbal medicine is commonly used in Oriental medicine to treat cerebrovascular disease. However, there is insufficient clinical evidence to actively support the safety of herbal medicine in clinical practice. Therefore, the aim of this study was to determine the toxicity and safety of four herbal medicines (Cheongsimyeonja-tang, Dodam-tang, Hyeolbuchukso-tang, and Boshiniknai-tang) in patients with cerebrovascular disease.Methods: This study used electronic medical records to analyze patients admitted to an oriental medicine hospital from April 1, 2017, to December 31, 2020. Liver and renal function values at the time of admission and discharge were compared.Results: A total of 25 patients were included in this study. We found no significant differences in various variables, such as complete blood count, liver-renal function test, and urine, before and after the administration of the four herbal medicines. Additionally, no significant adverse events related to herbal medicine were observed.Conclusions: This study confirmed the safety of the four herbal medicines in patients with cerebrovascular disease who were hospitalized in a single Oriental medicine hospital.
A Study on the Anti-Inflammatory Effect and Improvement of Dyslipidemia on Hyangsapyeongwi-san
Authors: Chae Han-nah , Chun Se-eun , Shin Yong-jeen
Published: July 2023

Objectives: This study aims to investigate the anti-inflammatory effect and improvement of dyslipidemia on Hyangsapyeongwi-san.Methods: In this study, HUVEC cells were cultured and treated with Hyangsapyeongwi-san to measure intracellular KLF2, eNOS, MCP-1, ICAM-1, and VCAM-1 gene expression levels related to anti-inflammation. The weight of experimental animals administered with Hyangsapyeongwi-san was measured, blood samples were biochemically analyzed, and liver tissues were reviewed to research histological changes.Results: Gene expression levels in the cells treated with Hyangsapyeongwi-san generally showed a meaningful anti-inflammatory effect. The body weight of the experimental animals decreased, and total cholesterol, triglyceride, and LDL-cholesterol in the blood generally declined while HDL-cholesterol tended to increase. Fat accumulation between hepatocytes was also reduced after the administration of Hyangsapyeongwi-san.Conclusions: This study confirmed that Hyangsapyeongwi-san has the effect of suppressing vascular inflammatory responses through the regulation of genes involved in the vascular inflammatory process and improving dyslipidemia through the reduction of blood lipids and weight loss.
Case Report on the Five-year Survival and Complete Response of a Patient with Pancreatic Cancer Treated with Integrative Medicine
Authors: Jung Yu-jin , Kim Jisoo , Park Kyung-Dug , Oh Yoona , Jeong Beom-Jin , Bang Sunhwi
Published: July 2023

Objectives: This is a five-year survival and complete response (CR) report on pancreatic cancer treated with western medicine and Korean traditional medicine.Method: A 59-year-old woman diagnosed with pancreatic cancer visited ⃝⃝ Korean traditional medicine hospital after neoadjuvant chemotherapy and pylorus-preserving pancreaticoduodenectomy. She was treated with Korean traditional medicine, including acupuncture, abdominal moxibustion, wild ginseng pharmacopuncture, and herbal medicine, which was based on integrated medicine therapy (IMT), from March 2018 to September 2022. The tumor size was measured by scanning with computed tomography (CT), magnetic resonance imaging, and positron-emission tomography/CT. Adverse events were evaluated using laboratory conclusion and National Cancer Institute Common Terminology Criteria for Adverse Events version 5.0.Result: During four years and three months of treatment, IMT maintained safety. The patient finally reached five-year survival without any recurrence or complication (CR) on October 26, 2022.Conclusion: We suggest that an integrative approach including Korean traditional medicine can be a meaningful treatment option for pancreatic cancer. Further studies should be performed to establish the proper treatment protocol of integrative medicine for pancreatic cancer.
DISEÑO MECATRÓNICO DE UN PROTOTIPO DE PLANTILLA INTELIGENTE DE BAJO COSTE PARA EL DIAGNÓSTICO DE LA PISADA DURANTE LA MARCHA
Authors: Muñoz-Palomino Manuel A. , Ruano Aldair , Solis-Pino Andrés Felipe
Published: July 2023

Los trastornos del pie pueden afectar a la salud del ser humano, por lo que se han realizado diferentes esfuerzos para conocer la distribución de fuerzas en la planta del pie, para lograr el diagnóstico y tratamiento de diferentes patologías. Este artículo describe el desarrollo e implementación de una plantilla inteligente para el análisis de patologías del pie, utilizando elementos de diseño mecatrónico y metodologías de co-diseño. La propuesta se valida mediante un estudio de caso en el que usuarios y profesionales sanitarios utilizan la plantilla y la evalúan. Los resultados sugieren un prototipo funcional que apoya el diagnóstico de diferentes afecciones del pie a partir de la estimación de la presión plantar, suponiendo una alternativa de bajo coste, con elementos a mejorar como la salubridad y las características físicas. La propuesta desarrollada muestra potencial como producto de bajo costo; aunque se identifican algunas limitaciones relacionadas con la usabilidad y el dominio de aplicación