bluuebunny/crossref_metadata_2025 huggingface dataset:
On the Relationship of Kitsch and Persuasion
Authors: Dąbrowska Dorota
Published: December 2021

The article concerns the problems of the relationship between kitsch and persuasion; it is an attempt to approach this relationship from two perspectives – indicating the persuasive nature of kitsch as one of its characteristics, and signaling the possibility of recognizing that the category of kitsch is present as a consequence of giving the message a persuasive character. The presented statements are based on the analysis of two films – God’s Not Dead, directed by Harold Cronk, and Body/Ciało, directed by Małgorzata Szumowska
Life as Kitsch. Notes about Bio Art
Authors: Mikołajewska Marta
Published: December 2021

Bio art is a specific trend of contemporary art practice, where artists adapt solutions offered by biosciences in order to create living works of art. Their actions are subject to a discussion with dominant voices concerning the significance of such experiments for the fundamental ascertainments concerning what life is, but also for understanding the status of these constructed entities, which have not existed in nature so far. Post-human discourses such as aesthetics of care, non-anthropocentric aesthetics and zoe-aesthetics are a few examples of this type of reflection. However, is it possible that works which could be described in terms of kitsch constitute a solid ground for this type of discussion? Clement Greenberg has written about kitsch that it is ‘mechanical and operates by formulas. Kitsch is vicarious experience and faked sensations. Kitsch changes according to style, but remains always the same. Kitsch is the epitome of all that is spurious in the life of our times’. If kitsch represents everything that is spurious and non-authentic in our life, can we use it in order to make general statements concerning the basis of life? Can we make statements concerning the fundamental problem of life on the basis of projects that confront us with glow-in-the-dark rabbits or paintings created with genetically modified color bacteria? In my paper I would like to refer to these questions on the basis of an artwork that can be classified in terms of kitsch.
Analysis and evaluation of groundwater protection alternatives during waste extraction operations (acid tars) in a lagoon in Arganda del Rey (Madrid)
Authors: Barettino Fraile D. , García Ruiz T. , Juncosa Rivera R. , Mora Peris P. , Prendes Alvargonzález E. , Salve Sánchez J. M.
Published: December 2021

The Community of Madrid is carrying out the integral restoration of an old gravel pit contaminated with hazardous waste, mostly petroleum sulphonates (acid tars), from the treatment of used industrial oil. Part of these discharges, from the 1970s and 1980s, were deposited in a lagoon generated by the exploitation of aggregates below the piezometric level of the aquifer, forming a raft with 50,000 m3 of hazardous waste. The different locations, nature and conditions of the waste require different solutions for its extraction and treatment, so the restoration project consists of several phases. The deposited waste produces an effect of confinement in the aquifer, since the bottom level of the waste is lower than the piezometric level. With these conditions, it is critical to establish a procedure for the protection of the groundwater when executing the next phase, consisting of the extraction of waste located below the piezometric level. This article describes the process that has been carried out to select the best alternative from a hydrogeological point of view, considering all the available data obtained in the previous phases of the project. Once all the possible alternatives had been considered and characterized in a reasoned way, we chose the construction of a perimeter barrier around the raft embedded in a clay layer of 2 m thick located in the base of the raft as the best option.
Mining in Ecuador. Past, present and future
Authors: Estupiñan Rocío , Romero Paola , García Mishel , Garcés Daniel , Valverde Priscila
Published: December 2021

The Ecuador National Government aims to consolidate the mining sector as the second export sector, focusing the actions on guaranteeing the investments and fighting again illegal mining. Therefore, the government officially presented the new Ecuador Mining Policy 2019 - 2030, and new reforms to the Mining Law are under discussion to encourage domestic and foreign investment. In addition, more control in the mining sectors by the Ministry of the Interior is being developed to combat illegal mining, which generates a high security risk for mining operation workers and for nearby populations, due to armed clashes and money-laundering. For this study the objective has been to diagnose the current state of mining in Ecuador, in different contexts: legal, environmental, social and economic. A 4% GDP contribution to growth in metallic mining is expected by the year 2021. The three most exploited non-metallic minerals are: limestone, clay and pumice. In addition, the largest exploitation volume occurs in construction materials, which are distributed throughout the country. Social conflicts are a fundamental issue in the mining sector, where there are different points of view about those different aspects such as economic development, business conduct, life cycle management, community welfare, working conditions, and environmental responsibility.
Oridonin Induces Oxidative Stress-mediated Cancer Cells Apoptosis via Targeting Thioredoxin Reductase
Authors: Duan Dongzhu , Wang Xiaoling , Feng Xiaolu , Pan Dabo , Wang Le , Wang Yanru
Published: December 2021

Background:

Thioredoxin reductase (TrxR) plays vital role in regulating cellular redox
balance as well as redox-mediated signal transduction. Accumulating evidence supports that
overactivation of TrxR is closely related to tumorigenesis and that targeting TrxR ablation reverses
the growth of numerous malignant tumors, making TrxR a promising target for cancer
chemotherapy. Thus, the discovery and development of molecules as promising anticancer agents
that target TrxR is of great significance. Oridonin was shown to inhibit TrxR activity, but the
detailed cellular mechanism is largely unknown.

Objective:

The study investigated the mechanism of action and underlying inhibitory properties of
oridonin on TrxR in HeLa cells.

Methods:

A covalent docking was performed to reveal the possible interaction between oridonin
and TrxR by Schrödinger Software Suite. TrxR activity was determined by 5,5’-dithiobis-2-
nitrobenzoic acid reduction assay and endpoint insulin reduction assay. Sulforhodamine B and
colony formation assay were employed to assess the viability and growth of cells. Reactive oxygen
species level was measured by probe 2’, 7’-dichlorfluorescein diacetate, and dihydroethidium.
Hoechst 33342 staining, caspase 3 activation, and fluorescein-5-isothiocyanate-conjugated Annexin
V and propidium iodide double staining were used to evaluate apoptosis.

Results:

Here, we reported the oridonin as a potent inhibitor of TrxR. Inhibition of TrxR results in a
decrease of thiols content and total glutathione, elevates reactive oxygen species levels, and finally
promotes oxidative stress-mediated apoptosis of cancer cells.

Conclusion:

Targeting TrxR by oridonin discloses a novel molecular mechanism underlying the
biological action of oridonin and sheds light on developing oridonin as a potential tumor therapeutic
agent.
CAR-NK Cells for Cancer Therapy: Molecular Redesign of the Innate
Antineoplastic Response
Authors: Rojas-Martinez Augusto , Cienfuegos-Jimenez Oscar , Vazquez-Garza Eduardo
Published: December 2021

:

The Chimeric Antigen Receptor (CAR) has arisen as a powerful synthetic biology-based
technology with demonstrated versatility for implementation in T and NK cells. Despite CAR T
cell successes in clinical trials, several challenges remain to be addressed regarding adverse events
and long-term efficacy. NK cells present an attractive alternative with intrinsic advantages over T
cells for treating solid and liquid tumors. Early preclinical and clinical trials suggest at least two
major advantages: improved safety and an off-the-shelf application in patients due to its HLA independence.
Due to the early stages of CAR NK translation to clinical trials, limited data is currently
available. By analyzing these results, it seems that CAR NK cells could offer a reduced probability
of Cytokine Release Syndrome (CRS) or Graft versus Host Disease (GvHD) in cancer patients, reducing
safety concerns. Furthermore, NK cell therapy approaches may be boosted by combining it
with immunological checkpoint inhibitors and by implementing genetic circuits to direct CAR-bearing
cell behavior. This review provides a description of the CAR technology for modifying NK
cells and the translation from preclinical studies to early clinical trials in this new field of immunotherapy.
Metabolomics Work Flow and Analytics in Systems Biology
Authors: Chacko Sanoj , Haseeb Yumna B. , Haseeb Sohaib
Published: December 2021

:

Metabolomics is an omics approach of systems biology that involves the development and assessment of large-scale, comprehensive biochemical analysis tools for metabolites in biological systems. This review describes the metabolomics workflow and provides an overview of current analytic tools used for the quantification of metabolic profiles. We explain analytic tools such as mass spectrometry (MS), nuclear magnetic resonance (NMR) spectroscopy, ionization techniques, and approaches for data extraction and analysis.
Prognostic Value of Long Non-coding RNAs in Urological Malignancies: A Systematic Review, and Meta-Analysis
Authors: Bagheri Zeinab , Arjmand Mohammad-Hassan
Published: December 2021

Background:

Many studies have explored the potential roles of long non-coding RNAs (lncRNAs) in urological cancer (UC) progression. The clinical outcome and prognosis of UCs remain weak. Therefore, finding clinical prognostic markers is needed to improve therapeutic potential. The aim of this study was to consider the possible association between the lncRNAs expression with the survival time and clinical outcomes in patients with UC.

Methods:

A literature search was performed in several related databases to find eligible English papers published before 9 February 2021. Hazard ratios (HRs) with 95% CI were calculated to investigate the association between lncRNAs expression and overall survival in patients with UC.

Results:

A total of 46 studies, including 39 lncRNAs were identified. Results indicated that lncRNAs expression was significantly correlated with poor overall survival (OS) outcome in patients with UCs (HR: 1.923, 95% CI: 1.448-2.554, P<0.001). Also, we divided included studies into up-regulated and down-regulated subgroups according to lncRNAs expression. The results indicated a significant association with poor OS outcomes in both up-regulated (HR=2.546, 95% CI: 1.896-3.41, P<0.001) and down-regulated (HR=0.33, 95% CI: 0.22-0.49, P<0.001). Moreover, expression of lncRNAs was significantly associated with lymph node metastasis (LNM) (OR=0.25, 95% CI: 0.13-0.47, P<0.001)

Conclusion:

Abnormal expression of various lncRNAs is a potential novel marker for predicting the clinical outcomes of urological tumors.
Locomotive Reliability Assessment Method
Authors: Gubarev P.
Published: December 2021

Abstract. The authors describe the analysis of the current state of the problem under consideration. A definition of "averaged failure flow parameter" is given. The periods of traction rolling stock life cycle are considered. The assumption of event distribution laws exponentiality is introduced, which makes it possible to obtain expressions of the main reliability indices in the analytical form. The work of depot service locomotives to ensure the required reliability and readiness of the rolling stock during their normal operation has been assessed. The introduction of the term "readiness" into the modern practice of traction rolling stock reliability estimation is considered. The initial data for calculating the indexes of locomotive uptime and readiness are presented. Calculated values of readiness and no-failure indices of electric locomotives in operation are obtained. The calculated values of internal and technical availability coefficients are compared with similar indicators established by technical specifications. Control procedures were performed to determine the compliance of each set of locomotives (EP1, 2ES4K) with the uptime requirements. As a result of comparing the calculated values of internal and technical availability factors (for electric locomotives EP1 and 2ES4K with analogous values set by specifications (EP1 and 2ES4K) it was determined that the surveyed locomotives comply with the established availability requirements. As a result of control procedures to determine the compliance of each set of EP1 and 2ES4K locomotives with the uptime requirements, it was determined that the set of 2ES4K electric locomotives for the run in question does not fully comply with the uptime requirement. And the set of EP1 electric locomotives meets the reliability requirements, but the error value is higher than 20%. To clarify both events, it is necessary to increase the mileage interval of the locomotives and repeat the procedure for determining compliance with the uptime requirements. The method of assessing the uptime and readiness of locomotives during their normal operation makes it possible to identify existing shortcomings in the operation of rolling stock and to form measures to improve the quality of rolling stock operation.
Improving the Efficiency of Turning Processing of Heat-Resistant Alloys by Introducing Ultrasonic Field Energy into the Cutting Zone
Authors: Khramov A.
Published: December 2021

Abstract. Studies have been carried out to assess the effectiveness of dry processing by the current preparations from the heat-resistant alloy CN45MVTUBR with mineral ceramic incisors with the introduction of the ultrasound-field energy treatment zone. It has been established that the use of ULTRASOUND in the rough treatment of mineral ceramic tools without coolant allows to reduce the depth of the defective layer in 1.5 times.
Methodology for the Study of Residual Temperature Stresses in the Butt Contour of a Welded Joint Made of Carbon and High-Alloy Structural Steels during Multi-Pass Welding
Authors: Mironova L.
Published: December 2021

Abstract. The method of investigation of residual temperature stresses in the butt contour of the welded joint "shell – plate" made of carbon and high-alloy structural steels during multi-pass welding is described. The temperature problem was solved on the basis of the obtained experimental data of temperature measurement at the reference points of the structure during the application of the rollers. A solution is proposed that takes into account several stages, each of which corresponds to a specific intermediate temperature field due to the peculiarities of welding technology. The evaluation of residual stresses was carried out on the basis of the energy theory of plasticity, taking into account the dependences of the yield strength and elastic modulus of welded metals on temperature.
Tribological Properties of Sapphire under Dry Friction against Chromium and Zirconium Ceramics
Authors: Alisin V.
Published: December 2021

Abstract. The issues of sapphire friction and wear in contact with chrome steel and zirconium ceramics are discussed in this article. The kinetic microindentation method is used to study the mechanical properties of sapphire in frictional contact in modelling experiments on the indentation of a Vickers indent. Taking into account the anisotropy of the mechanical properties of sapphire, the influence of the load and orientation of the indent on the modulus of elasticity and hardness is analyzed. It has been established that, under dry friction conditions it is promising the use of zirconium ceramics in the supports of devices operating under conditions in which the use of lubricants is impossible. The possibility of using a friction couple of sapphire-zirconium ceramics in friction units operating in open space is noted.
Development of Abrasive Grain Coating Technology Protective Polymer Casing for Water-Abrasive Cutting
Authors: Kozhus O.G.
Published: December 2021

Abstract.The article presents the technology of covering abrasive grains with a protective polymer shell, which allows to reduce the wear of the focusing tube of the nozzle of a hydroabrasive installation. A description of the manufacturing process of a prototype abrasive with a polymer coating in a fluidized bed is presented in order to determine the critical processing modes at which a high-quality product will be obtained in a minimum operating time of the installation.
Analytical and Experimental Study of Grinding Forces with Flap Wheels
Authors: Unyanin A.N.
Published: December 2021

Abstract. Analytically, the dependences for calculating the grinding forces with flap wheels are obtained. The forces were defined as the sum of the forces associated with dispersion and friction of the cutting and plastically deforming petal grains against the workpiece. The dependencies take into account the change in the depth of penetration of the grain into the workpiece material along the length of the arc of the contact of the circle with the workpiece. Numerical modeling and experimental study of forces have been carried out. The discrepancy between the calculated and experimental values of the forces does not exceed 20%.
Contemporary Methods for Production of Ultramarine
Authors: Vyboishchik A.V.
Published: December 2021

Abstract. The article describes the features of ultramarine, its modifications, viz. ultramarine blue. The requirements for ultramarine blue grades are observed, the one-stage and two-stage technologies for the production of ultramarine blue are described, the advantages and disadvantages of both methods are listed, new recommendations for the production of ultramarine blue are offered.
Determining the Diameter of Reinforcing Bars Inside Concrete Structures Regardless of Magnetic Properties
Authors: Mikhailov A.V.
Published: December 2021

Abstract. In this work, using a series of numerical experiments, the dependence of the magnetic field strength of the response of the reinforcing bar to an external magnetizing field on the magnetic properties of the reinforcing bar was investigated. The possibility of determining with high accuracy the diameter of reinforcing bars, regardless of the magnetic properties of the material from which they are made, has been proven.
Thermal Treatment of Carbidostals TiC – I2XI8H10T
Authors: Savinykh L.M.
Published: December 2021

Abstract. An important task of thermal treatment of carbidostals having different composition of titanium carbide and steel I2XI8H10T is the possibility of improving their strength properties during operation under abrasive wear conditions. This question is new and little studied.
Development of an Experimental Robotic Complex for Direct Metal Deposition and Testing of Deposition Modes for Heat-Resistant Powder Material
Authors: Oleynik M.A.
Published: December 2021

Abstract. The paper considers the issue of optimizing the movement of an industrial robot used in additive manufacturing in the technology of direct metal deposition of parts. The developed mathematical model that takes into account the joint work of a six-axis robot manipulator and a two-axis positioner is described. The algorithm for calculating the motion based on the relative position of two adjacent points of the working tool trajectory relative to the rotary axis of the positioner with a given accuracy is described. The simulation of processing is carried out both when working only with the manipulator, and when working together with a two-axis positioner, and control programs with recalculated coordinates and rotation angles of the positioner are obtained.
Influence of the Technology of Obtaining the Material of the Cathode of the Cu – Fe System at the Depth of Penetration of Ions into the Titanium Target
Authors: Ovchinnikov V.V.
Published: December 2021

Abstract. The article presents the results of the influence of the technology of obtaining the material of the cathode of the implanter of the Cu – Fe system on the penetration depth of the titanium alloy VT20. It is shown that the use of 50% Cu – 50% Fe material as the material of the cathode of the implanter, obtained by alloying copper and iron, leads to a better increase in the thickness of the ion-doped layer than the use of the cathode obtained by powder metallurgy.
Influence of Heat Treatment on Structure and Durometric Properties of Coatings Obtained by Surfacing with CSR-04СR27NI7MO3CU2Т Cast Rods
Authors: Nazarko A.
Published: December 2021

Abstract. The effect of heat treatment modes on the structure and durometric properties of coatings obtained by surfacing with CSR-04СR27NI7MO3CU2Т cast rods, is considered. It is found that the temperature of 800°С and soaking time of 5 hours are optimal to increase the deposited metal hardness. It is shown that such a phenomenon results from the formation of the austenitic structure hardened by the precipitates of the σ-phase (FeCr), chromium carbides (Cr3C2) and titanium carbides (TiC). The heat treatment modes proposed can be applied in the wear-resistant surfacing technology of chemical equipment parts.
Effect of Process Modes on Tangential Component of Cutting Force during Belt Rotary Grinding of Aluminium Alloy Blanks D 16
Authors: Stadnik T.
Published: December 2021

Abstract. These days, in the manufacture of units and mechanisms of ships, aircraft and other technological machines, industrial robots, long-sized products from D 16 (Standart GOST-R) aluminum alloy are used, for the processing of which a complex for belt rotary grinding has been developed. The outcome measures of the rotary belt grinding process depend on the cutting forces generated during the processing process. According to cutting forces, process stability is diagnosed, values of surface roughness indices, temperatures and cutting modes are calculated according to displacement balance equation. The article is devoted to obtaining a mathematical model establishing the relationship between the tangential component of the cutting force and cutting modes during belt rotary grinding of D 16 aluminum alloy.
COVID-19 impacts on virtual exchange around the world
Authors: Bali Maha , Goes Paulo , Haug Eva , Patankar Anita
Published: December 2021

The COVID-19 pandemic has simultaneously created both opportunities and challenges for the emerging field of virtual exchange: On one hand, institutional administrators and funding organisations saw virtual exchange as the solution to global learning needs while physical travel was restricted and traditional mobility programmes were suspended. On the other hand, instructors felt overwhelmed by transitioning all of their teaching online, and without physical access to their educational institutions, many students and instructors lacked reliable internet connections or safe places to engage in learning, not to mention the financial burdens of the pandemic.
This moderated panel discussion which took place during the IVEC 2020 conference invited diverse perspectives to explore the impacts of the pandemic on virtual exchange in various contexts around the world. Central to the discussion were issues of equity, inclusion and justice: Is virtual exchange truly a more accessible and equitable form of global learning, as it is often promoted to be?
In this video contribution, Eva Haug moderates the conversation between Maha Bali, Paulo Goes, and Anita Patankar around the following questions.
* How is virtual exchange a solution to global learning during COVID-19?
* What have been the two to three most relevant impacts of the pandemic on virtual exchange activity at your institution, in your country, or region of the world?
* How can we as a field of practitioners maintain and sustain the current momentum and interest in VE in a post-COVID-19 world?
* Can intercultural exchange be apolitical?
* If an institution is in a position of power or privilege, how can they create space in virtual exchange for institutions that are less represented?

The video recording is accessible on: https://vimeo.com/459415071 (CC BY-NC-NC)
Effects of Circadian Rhythm on Migraine Therapy
Authors:   Department of Neurology, University of Florida College of Medicine, US, Salamatova DO Yulia , Packard MD Andreja ,   Neurology Department, Sleep Section, Arnold 2 2435 G, 1 South Prospect St, Burlington VT, US
Published: December 2021

Circadian rhythms are 24-hour cycles of physical, mental, and behavioral changes regulated and maintained by the internal primary circadian clock, however modifiable by a number of external cues or “zeitgebers”, the most powerful one being light. Core set of clock genes regulate the whole-body metabolism and transcription of over 40% of mammalian RNA, including that for drug transporters, binding and metabolizing proteins responsible for regulation of pharmacokinetics of vast array of medications. Growing amount of evidence also shows circadian rhythmicity of a number of patho-physiological processes, such as are migraine, chronic pain, and epilepsy, suggesting amenability to chronotherapy. Chronotherapy involves behavioral and pharmacological strategies to restore or correct ill-functioning circadian rhythm as well as manipulation of standardized treatments throughout the day to maximize therapeutic and minimize side effects, termed chronopharmacology. Chronotherapy for chronic migraines and headache variants using synchronization techniques as well as chronopharmacology of abortive and preventive migraine medications is being actively researched. In this review, we summarize current state of chronotherapy for headache variants and discuss future prospects in circadian optimization of migraine headaches treatment.
The Successes and Challenges of Implementing Telehealth for Diverse Patient Populations Requiring Prenatal Care During COVID-19: Qualitative Study
Authors: Farrell Ruth , Collart Christina , Craighead Caitlin , Pierce Madelyn , Chien Edward , Frankel Richard , Tucker Edmonds Brownsyne , Perni Uma , Coleridge Marissa , Ranzini Angela C , Rose Susannah
Published: December 2021

Background

Although telehealth appears to have been accepted among some obstetric populations before the COVID-19 pandemic, patients’ receptivity and experience with the rapid conversion of this mode of health care delivery are unknown.

Objective

In this study, we examine patients' prenatal care needs, preferences, and experiences during the COVID-19 pandemic, with the aim of supporting the development of successful models to serve the needs of pregnant patients, obstetric providers, and health care systems during this time.

Methods

This study involved qualitative methods to explore pregnant patients’ experiences with prenatal health care delivery at the onset of the COVID-19 pandemic. We conducted in-depth interviews with pregnant patients in the first and second trimester of pregnancy who received prenatal care in Cleveland, Ohio, from May to July 2020. An interview guide was used to probe experiences with health care delivery as it rapidly evolved at the onset of the pandemic.

Results

Although advantages of telehealth were noted, there were several concerns noted with the broad implementation of telehealth for prenatal care during the pandemic. This included concerns about monitoring the pregnancy at home; the need for additional reassurance for the pregnancy, given the uncertainties presented by the pandemic; and the ability to have effective patient-provider discussions via a telehealth visit. The need to tailor telehealth to prenatal health care delivery was noted.

Conclusions

Although previous studies have demonstrated that telehealth is a flexible and convenient alternative for some prenatal appointments, our study suggests that there may be specific needs and concerns among the diverse patient groups using this modality during the pandemic. More research is needed to understand patients' experiences with telehealth during the pandemic and develop approaches that are responsive to the needs and preferences of patients.
Life Course Digital Twins–Intelligent Monitoring for Early and Continuous Intervention and Prevention (LifeTIME): Proposal for a Retrospective Cohort Study (Preprint)
Authors: Milne-Ives Madison , Fraser Lorna K , Khan Asiya , Walker David , van Velthoven Michelle Helena , May Jon , Wolfe Ingrid , Harding Tracey , Meinert Edward
Published: December 2021

BACKGROUND

Multimorbidity, which is associated with significant negative outcomes for individuals and health care systems, is increasing in the United Kingdom. However, there is a lack of knowledge about the risk factors (including health, behavior, and environment) for multimorbidity over time. An interdisciplinary approach is essential, as data science, artificial intelligence, and engineering concepts (digital twins) can identify key risk factors throughout the life course, potentially enabling personalized simulation of life-course risk for the development of multimorbidity. Predicting the risk of developing clusters of health conditions before they occur would add clinical value by enabling targeted early preventive interventions, advancing personalized care to improve outcomes, and reducing the burden on health care systems.

OBJECTIVE

This study aims to identify key risk factors that predict multimorbidity throughout the life course by developing an intelligent agent using digital twins so that early interventions can be delivered to improve health outcomes. The objectives of this study are to identify key predictors of lifetime risk of multimorbidity, create a series of simulated computational digital twins that predict risk levels for specific clusters of factors, and test the feasibility of the system.

METHODS

This study will use machine learning to develop digital twins by identifying key risk factors throughout the life course that predict the risk of later multimorbidity. The first stage of the development will be the training of a base predictive model. Data from the National Child Development Study, the North West London Integrated Care Record, the Clinical Practice Research Datalink, and Cerner’s Real World Data will be split into subsets for training and validation, which will be done following the k-fold cross-validation procedure and assessed with the Prediction Model Risk of Bias Assessment Tool (PROBAST). In addition, 2 data sets—the Early-Life Data Cross-linkage in Research study and the Children and Young People’s Health Partnership randomized controlled trial—will be used to develop a series of digital twin personas that simulate clusters of factors to predict different risk levels of developing multimorbidity.

RESULTS

The expected results are a validated model, a series of digital twin personas, and a proof-of-concept assessment.

CONCLUSIONS

Digital twins could provide an individualized early warning system that predicts the risk of future health conditions and recommends the most effective intervention to minimize that risk. These insights could significantly improve an individual’s quality of life and healthy life expectancy and reduce population-level health burdens.

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/35738
ONTOLOGICAL MODEL OF NIKIFOR CHERNIGOVSKY’OSTROG
Authors:   I.E.Eremin Amur state university, Eremin I.E. , Natsvin A.V. ,   A.V.Natsvin Amur state university, Lokhov A.Iu. ,   A.Iu. Lokhov Amur state university
Published: December 2021

The paper presents the technology of computer modeling of the general structure of a complete-ly lost architectural complex, implemented on the basis of fragmental refer-ence information. The author's interpretation of the most viable reconstruction of the object under study is present-ed.
FUNCTIONAL APPROACH TO THE SYNTHESIS OF CONCURRENT ERROR-DETECTION CIRCUIT BASED ON BOOLEAN COMPLEMENT AND USE OF "2-OUT-OF-5" CONSTANT-WEIGHT CODE
Authors:   D.V. Efanov Russian University of Transport, Efanov D.V. , Pivovarov D.V. ,   D.V. Pivovarov Russian University of transport
Published: December 2021

A method for self-checking concurrent error-detection circuit synthesis based on Boolean com-plement and "2-out-of-5" constant-weight code is described. The method is notable for using functional relationship between the signals from the working and control outputs instead of ana-lyzing the unit performance on each input. The functional dependence is established with due account to the requirements for the formation of codewords of the "2-out-of-5" code and a com-plete tester check. In addition, it considers the formation of a complete set of test combinations for transformation elements in the concurrent error-detection circuit. A method for obtaining a functional relationship between the control outputs and the operating outputs of the diagnostic object is presented. One of the options for extending the definition of the control function values is presented, as well as the functional dependence. It is noted that the number of options for ex-tending the definition of the control function values is large, which allows numerous options for synthesizing a concurrent error-detection circuit for any diagnostic object based on the described method. The use of the "2-out-of-5" code for the synthesis of concurrent error-detection circuits applying the Boolean complement method proved its effectiveness for organizing self-checking digital devices in automatics and computer technology.
RECREATIONOFA 3D-MODEL OF THE RELIEF OF THE ALBAZIN OSTROG
Authors:   EVGENY ALEXANDROVICH MASLAKOV Amur State University, MASLAKOV EVGENY ALEXANDROVICH , POPOV MAXIM ANDREEVICH ,   MAXIM ANDREEVICH POPOV Amur State University
Published: December 2021

The article discusses the means and methods of three-dimensional modeling of the terrain of a particular area. A photorealistic computer visualization of the Albazinsky ostrog is presented.
INCREASING ENERGY EFFICIENCY AND SELECTION OF RATIONAL OPERATION PARAMETERS OF BOILER UNITS
Authors:   YULIA VLADIMIROVNA KHONDOSHKO Amur State University, KHONDOSHKO YULIA VLADIMIROVNA
Published: December 2021

The article deals with the main problems of boiler houses operating on solid low-grade fuel. The ways of increasing energy efficiency and methods of more rational use of the existing boiler equipment are proposed.
EVOLUTION OF THE DIELECTRIC PROPERTIES OF SODIUM NITRITE INTRODUCED INTO ALUMINUM OXIDE NANOPORES
Authors:   ALEXEY VLADIMIROVICH PAVLOV Amur State University, PAVLOV ALEXEY VLADIMIROVICH , STUKOVA ELENA VLADIMIROVNA ,   ELENA VLADIMIROVNA STUKOVA Amur State University, ZOTOVA OKSANA VASILIEVNA ,   OKSANA VASILIEVNA ZOTOVA Amur State University, GOLUBEVA IRINA ANATOLYEVNA ,   IRINA ANATOLYEVNA GOLUBEVA Amur State University
Published: December 2021

This work presents the results of studying the evolution of the dielectric properties of nanocomposite NaNO2/Al2O3 samples with pore sizes of 100 and 70 nm. The samples were examined by dielectric spectroscopy. It is shown that in nanosized sodium nitrite embedded in porous aluminum oxide, the effect of «aging» associated with the time factor is observed. A decrease in the values of the dielectric constant is observed during long-term storage of the sample under normal conditions.
Formulation of Anti Acne Sheet Mask from Bandotan Leaf Extract (Ageratum conyzoides L.) against Propionibacterium acnes
Authors: Ginting Pricella , Leny Leny , Hafiz Ihsanul , Hasibuan Romauli
Published: December 2021

Acne can occur due to increased sebum excretion, inflammation of the skin triggered by the bacteria Propionibacterium acnes, Staphylococcus epidermidis, Staphylococcus aureus. The purpose of this study was to determine the formulation of sheet mask preparations of bandotan leaf extract (Ageratum conyzoides L.) in inhibiting the growth of Propionibacterium acnes bacteria. This type of research is an experimental study which include plant identification, making ethanol extract of bandotan leaves, making sheet mask formulations, evaluating the characteristics of the preparation and testing antibacterial activity using disc paper method using Mueller Hinton Agar media. The extract was carried out by maceration using 70% ethanol as a solvent. Testing the effectiveness of antibacterial by measuring the diameter of the inhibition zone, after that the data were analyzed using the One Way ANOVA statistical test. The results of the evaluation of the preparation showed that the preparation was homogenous, with pH ranging from 4.5 to 6.5 and the preparation did not cause irritation on volunteers skin. The results of the inhibition zone measurements showed that the inhibition zones at 2.5% concentration is 4.7mm, 5% (6.83mm), 7.5% (10.2mm) and positive control (20.57mm). This means that the higher the concentration, the larger the diameter of the inhibition zone obtained. The conclusion in this study is bandotan leaf extract (Ageratum conyzoides L.) can be formulated into anti acne sheet mask which is stable during storage with a strong inhibitory power at 7.5% concentration, which is 10.2 mm.

Keywords: Ageratum conyzoides L., bandotan leaf, Propionibacterium acnes, sheet mask
Development and Application of the Intelligent Seed Processing Technology and Equipment
Authors: Jia Sh. , Liu G. , Jia J. , Yang T.
Published: December 2021

Seed processing is an important link in the seed industry chain. Crop seed industry is a national strategic and basic core of industry. Drying, cleaning, selecting, grading, coating, packaging and storage of crop seeds are the main measures to realize the precision sowing of crops and the increase of grain yield and income. Continuously improving the intelligence and fi ne level of seed processing equipment is of great signifi cance to ensure the production and supply of excellent seeds and the stability of agricultural production. This paper describes the development status of modern seed processing equipment technology in China, introduces the establishment of seed processing equipment engineering technology research center, taking maize, rice, wheat and cotton seed processing technology and machinery as an example, describes the key technologies and technological process of the breakthrough in the major crop seed processing, analyzes the existing problems of seed processing equipment in China at this stage as well as the development trend in the future, provides a reference for government decision makers in resolving the problem of mechanical damage in the process of seed processing and further improving the intellectualization level of seed processing, promotes the common progress of the global seed processing equipment technology.
Digital technologies and robotic devices in the agriculture
Authors: Lobachevskiy Ya. P. , Dorokhov A. S.
Published: December 2021

The agricultural industry in the Russian Federation is dynamically developing; the agricultural export amounts to $ 25 billion. In other countries, in turn, this figure is much higher, for example, in China it has exceeded $ 75 billion. The existing potential can be realized if the efficiency of agricultural production is increased by creating and implementing automation, robotization, digital technologies, and artificial intelligence. As a result it may lead to a 2.5-3.5-fold increase in labor productivity; a 2-3-fold increase in the yield of crops; a 3-4-fold cut in energy consumption and material costs, ensuring the ecological safety of agricultural production and the environment. The authors developed the concept of intelligent agriculture and identified the following areas of digital technology applications: integrated production management; digital technologies in crop production, animal husbandry, energy supply, products storage and processing ; digital engineering for rural areas. The authors presented the stages of agricultural production digitalization, including: a system for monitoring the conditions and parameters of agricultural production; information transmission system; artificial intelligence and cloud technologies, setting the foundation for management decision-making; the implementation of management decisions by robotic devices. The authors presented the examples of using digital technologies in soil cultivation, horticulture, animal husbandry, and artificial ecosystems. In animal husbandry, these technologies prove to facilitate the monitoring of the animals movement, their physiological state, parameters of the microclimate on the premises, feed and milk quality control. The Federal Scientific Agroengineering Center VIM is reported to have the necessary educational infrastructure, accredited Master’s and postgraduate studies for training specialists in digital agriculture.
Political Eﬀects of Digital Transformation of Urban Governance (On the Example of Moscow)
Authors: Balayan A. A. , Tomin L. V.
Published: December 2021

The paper is devoted to the study of particular political eﬀects of digitalization of urban governance in the Russian Federation. Based on the concept of «surveillance capitalism» and research on the digital transformation of public administration, the authors analyzes the structure and logic of functioning of the «smart city» model using the example of Moscow. Based on the material of street protests, the political eﬀects of the use of digital infrastructure by the city authorities, in particular, camera systems with face recognition technologies, are examined. The study of the Russian situation correlates with the latest decisions of the United Nations (UN) Human Rights Council and the European Union’s initiatives to control remote biometric recognition technologies.
Perancangan Aplikasi Sistem Informasi Penyewaan Gedung Serbaguna Wilayah Jakarta Barat
Authors: Agustami Sundari , Mutu Manikam Ratna
Published: December 2021

Abstract The development of the day is increasingly rapidly, as well as technological advances.  Especially in computerised field. Computer is a tool to help work primarily in the field of business. Therefore, the community needs technology to complete its work and the presence of computer technology that is increasingly modern, fast and practical greatly affects the life of the wider community. The speed and accuracy of the information usually takes a long time, now in just a matter of seconds the information we can already receive.  By looking at the development of computer technology today, it is very important for the business world to improve the customer service and provide facilities in the rental service of West Jakarta area. Some buildings in West Jakarta are currently booking the building is still done manually so that it can cause errors and loss on consumer data data. In this case, the design of information system will be done to help booking a multipurpose building in West Jakarta area. Design to be created using UML. With the computerized can achieve effective activities in conducting activities on the building reservations. Keywords: Information, system design, multipurpose building reservations, UML AbstrakPerkembangan zaman semakin hari semakin pesat, begitu juga dengan kemajuan teknologi.  Terutama dibidang komputerisasi. komputer merupakan alat untuk membantu pekerjaan terutama dibidang bisnis. oleh karena itu, masyarakat membutuhkan teknologi untuk menyelesaikan pekerjaannya Dan adanya  teknologi komputer yang semakin modern, cepat dan praktis sangat mempengaruhi kehidupan masyarakat luas. Kecepatan dan keakuratan informasi yang biasanya memerlukan waktu yang lama, kini hanya dalam hitungan detik informasi tersebut sudah dapat kita terima.  Dengan melihat perkembangan teknologi komputer saat ini, hal yang sangat penting bagi dunia bisnis adalah untuk meningkatkan pelayanan konsumen dan memberikan kemudahan dalam pelayanan penyewaan gedung serbaguna wilayah Jakarta barat. Beberapa gedung di Jakarta barat saat ini pemesanan gedung masih dilakukan secara manual sehingga dapat menyebabkan kesalahan dan kehilangan pada data data konsumen. Dalam hal ini akan dilakukan perancangan sistem informasi untuk membantu pemesanan gedung serbaguna wilayah Jakarta barat. Perancangan yang akan dibuat menggunakan Unified Modeling Language(UML). Dengan adanya komputerisasi dapat tercapainya kegiatan yang efektif dalam melakukan aktifitas pada pemesanan gedung.  Kata kunci: perancangan , sistem informasi, pemesanan, gedung serbaguna, UML
Monitoring Server Berbasis SNMP Menggunakan Cacti pada Server Lokal
Authors: Rasyiidin Muhammad Yusuf Bagus , Murad Fachroni Arbi , Murad Fachroni Arbi
Published: December 2021

Abstract - SNMP is a network protocol used for monitoring network devices, especially servers, which allows senders and recipients to exchange information. With SNMP all device activities can be monitored using several additions available on Linux operating systems namely apache, PHP, SNMP, MySQL, and Cacti. Server monitoring is needed to find and solve some problems on a network that has many devices, aiming to monitor all network devices using Cacti. A problem that often occurs on a network is a slow connection and disconnected, with the presence of Cacti a network administrator can identify problems and fix them.
Towards closed carbon loop fermentations: co-feeding of Yarrowia lipolytica with glucose and formic acid
Authors: Winden Wouter Van , Mans Robert , Breestraat Stefaan , Verlinden Rob , Mielgo-Gómez Alvaro , Hulster Erik de , Bruijn Hans De , Noorman Henk
Published: December 2021

A novel fermentation process was developed in which renewable
electricity is indirectly used as a fermentation substrate,
synergistically decreasing both the consumption of sugar as a first
generation carbon source and emission of the greenhouse gas CO2. To
achieve this, a glucose-based process is co-fed with formic acid, which
can be generated by capturing CO2 from fermentation offgas followed by
electrochemical reduction with renewable electricity. This ‘closed
carbon loop’ concept is demonstrated by a case study in which co-feeding
formic acid is shown to significantly increase the yield of biomass on
glucose of the industrially relevant yeast species Yarrowia lipolytica.
First, the optimal feed ratio of formic acid to glucose is established
using chemostat cultivations. Subsequently, guided by a dynamic
fermentation process model, a fed-batch protocol is developed and
demonstrated on laboratory scale. Finally, the developed fed-batch
process is proven to be scalable to pilot scale. An extension of this
proven concept to also recycle the O2 that is co-generated with the
formic acid to the fermentation process for intensification purposes,
and a potential further application of the concept to anaerobic
fermentations are discussed.
Looking for Better: A History of Black Southern Migrations
Authors: Sanderfer Doss Selena
Published: December 2021

A broad overview of migrations affecting black southerners is presented, including the Atlantic slave trade, the domestic slave trade, colonization movements to Sierra Leone and Liberia, the Exoduster movement, the Great Migration, and the Return South migration. Emigrants convey their experiences and motivations through testimonies and personal accounts. Surviving the trauma of forced migrations, black southerners organized numerous migration movements both outside and within American polities in search of better opportunities. In the late 20th century, black southerners also initiated a return migration to the American South and have since achieved notable socioeconomic and political progress.