bluuebunny/crossref_metadata_2025 huggingface dataset:
Experience of mono and combined treatment of retinopathy of prematurity with the use of laser coagulation of the retina and the introduction of vascular endothelial growth factor inhibitors
Authors:   The S. Fyodorov Eye Microsurgery Federal State Institution, Novosibirsk, Belousova K.A. , Mamulat D.R. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, Novosibirsk, Sharokhin M.A. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, Novosibirsk, Solovyova V.V. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, Novosibirsk
Published: April 2023

Retinopathy of prematurity (ROP) is one of the main causes of blindness and visual impairment in young children. Laser coagulation of the avascular retina is a generally recognized method of treating active progressive ROP. The efficiency of laser coagulation depends on the type of ROP. Combined treatment is used when one of the types of monotherapy is ineffective. Purpose. To evaluate the effectiveness of mono and combined treatment of ROP using laser coagulation and introduction of vascular endothelial growth factor inhibitors. Material and methods. In the period 2020–2022, 403 babies born prematurely were under observation. The diagnosis of ROP was made to 170 (42 %) children. 47 (27 %) patients needed treatment. Mono laser coagulation was performed in 32 (68 %) patients, and 9 (19.1 %) were administered introduction of vascular endothelial growth factor inhibitors. Conclusions. Combined treatment was carried out on 6 (12.7 %). In all cases of PH treatment, a positive result was achieved with the preservation of vision. If we consider the PH of the scar phase of the 3rd degree as an unfavorable outcome, then success is achieved only in 95.6 % of cases. Combined treatment proved to be justified and effective – in our observation in 6.4 % of cases. The results of our study confirm the expediency of monitoring children after the introduction of vascular endothelial growth factor inhibitors until they reach the postconceptual age of 70–80 weeks. Keywords: retinopathy of prematurity, laser photocoagulation of the retina, inhibitors of vascular endothelial growth factor, combined treatment, monotherapy
Navigational laser retina coagulation in adults Coats' disease (clinical case)
Authors:   S.N. Fedorov NMRC «MNTK «Eye Microsurgery» Cheboksary branch, Pimenova I.E. , Voskresenskaya A.A. ,   S.N. Fedorov NMRC «MNTK «Eye Microsurgery» Cheboksary branch, Valeуeva D.R. ,   S.N. Fedorov NMRC «MNTK «Eye Microsurgery» Cheboksary branch
Published: April 2023

Purpose. To analyze the results of retina selective focal laser coagulation in adults Coats' disease on clinical case. Material and methods. A topographically-oriented laser treatment was performed on a patient with a rare form of unilateral Coats disease complicated by retinal edema using a modern navigation laser system «NAVILAS» and multimodal visualization. The follow-up period was 6 months. Results. Using the complex of modern diagnostic methods, the multiple vascular anomalies was revealed. Due to the selective laser coagulation the most identified macroaneurysm`s regression and exudation`s resorption with subsequent stabilization of visual functions during the observation period was achieved. Conclusion. The combined approach with modern imaging techniques and navigational planning of laser surgery makes it possible to informatively identify and accurately perform the treatment. Keywords: Coat's retinitis, vascular malformations, subretinal exudates, telangiectasia, focal laser coagulation, navigational laser surgery
Features and patterns of the course of photoinduced retinal veins thrombosis in the experiment
Authors:   Siberian State Medical University, Tomsk, Krylova A.A.
Published: April 2023

Central retinal vein occlusion (CRVO) was first described in the 19th century, but some aspects of the pathogenesis of the disease remain controversial to this day [1]. In the development of retinal vein obturation hemorheological, coagulation, hemodynamic and immune-inflammatory factors are important [2, 3]. Creation of an experimental model of CRVO and its branches (BRVO) as close as possible to the natural course of the disease, will provide new knowledge about the pathogenesis of retinal vein obturation, which may help in the development of a new method for treating this pathology. Purpose. To study patterns of the course of photoinduced retinal vein occlusion in an in vivo experiment. Materials and methods. The experiment was carried out on 40 rabbits, which reproduced photoinduced CRVO and BRVO by introducing «Photoditazine» and laser irradiation of the retinal vessels of the right eye. The left eye of the animals remained intact and constituted the comparison group. On days 1, 3, 7, and 14 after the intervention, ophthalmoscopy, optical coherence tomography of the retina was performed, and 10 rabbits were taken out of the experiment, followed by enucleation, hematoxylin-eosin staining, and light microscopy of the structures of the posterior segment of the eyeball. Fluorescein angiography retinal vessels was performed on days 3 and 7 after modeling thrombosis of the retinal vein. Statistical processing of the obtained results was carried out using the IBM SPSS Statistics 27 program. Differences were considered statistically significant at p < 0.05. Results. With experimental photoinduced CRVO and BRVO, a mixed thrombus is formed in the vessel, occupying more than half of the retinal vein diameter, which causes an increase in the time of venous perfusion by 2.0 times (p = 0.047) compared with the intact eyes of rabbits, as well as pronounced microcirculation disorders, leading to the development of cystic macular edema and the appearance of non-perfused areas of the retina. Conclusions. An experimental study of photoinduced thrombosis of the retinal veins confirmed the feasibility of early treatment before the occurrence of complications of occlusion of the CRVO and BRVO, since changes in chorioretinal structures and hemodynamic disturbances in the retinal vessels microvasculature appear as early as 1-3 days after the formation of a thrombus in the retinal vessel lumen. Keywords: experimental model, central retinal vein occlusion, branch retinal vein occlusion, pathogenesis, microcirculation
Functional and morphological efficacy of surgical treatment of macula ruptures of different etiologies by implantation of amniotic membrane
Authors:   Tashkent State Dental Institute, Khera A. , Yangieva N.R. ,   Tashkent State Dental Institute, Agzamova S.S. ,   Tashkent State Dental Institute
Published: April 2023

The aim of the study was to evaluate the effectiveness of amniotic membrane implantation in macula ruptures. The study included 86 eyes with a macular tear greater than 400 µm. The technique of implantation of the amniotic membrane in case of macular ruptures provides anatomical success in 96.51 % of cases and functional success in 91.86 % of cases. Macular rupture as a complication of vitreomacular traction syndrome was the least favorable prognostic situation compared to traumatic (p < 0.01) and myopic ruptures (p < 0.05). Keywords: macular rupture, vitreoretinal surgery, amniotic membrane, anatomical and functional success
Aspects of macular surgery in patients with pathological myopia
Authors:   The S. Fyodorov Foundation to promote the development of advanced medical technology, Moscow, Magaryan T.O. , Mironov A.V. ,   The S. Fyodorov Foundation to promote the development of advanced medical technology, Moscow, Sharko A.S. ,   The S. Fyodorov Foundation to promote the development of advanced medical technology, Moscow, Kutin I.M. ,   The S. Fyodorov Foundation to promote the development of advanced medical technology, Moscow
Published: April 2023

Patient with high and ultra-high myopia belong to the one of the most difficult categories for the vitreoretinal surgery because of the morphological features of choroid, retina and vitreomacular interface: axial length over 26 mm, the presence of posterior staphyloma, thinning of choroid, a combination of hypo- and hyperpigmentation of the retina pigment epithelium. Therefore, the improvement of the technique of vitreoretinal surgery in patients with pathological myopia remains relevant. Purpose. To optimize the technique of vitreoretinal surgery in patients with pathological myopia. Material and methods. There are 14 patients (14 eyes) with myopic traction maculopathy against the background of pathological myopia with clinical refraction from 10 to 26 D were under observation. The axial length of the eye averaged 31.23 ± 1.94 mm. All patients underwent microinvasive three-port vitrectomy 25G. In connection with the anatomical features of the myopic eye, special methods of surgical manipulations in the macular region were used. Results. The obtained positive anatomical and functional results of the treatment demonstrated their effectiveness and safety, which made it possible to develop a certain algorithm for surgical manipulations in macular surgery in patients with pathological myopia. Conclusion. The use of non-standard techniques of vitreoretinal surgery, highly specialized tools and methods for visualizing the structures of the central zone of the retina optimizes the results of the treatment of macular pathology in patients with pathological myopia. Keywords: high myopia, traction maculopathy, epiretinal membrane, vitrectomy, cataract
Overview Industri Halal di Perdagangan Global
Authors: Rahmawati  , Husni Thamrin  , Zulfadli Nugraha Triyan Putra
Published: April 2023

Tulisan ini membahas mengenai industri halal di perdagangan global. Permasalahan yang sering terjadi pada industri halal yakni rendahnya jumlah produk-produk bersertifikat halal, regulasi pemerintah, dan sumber daya manusia yang minim pemahaman halal. Masalah-masalah tersebut harus ditemukan solusi dalam mengatasinya. Rumusan masalah pada penelitian ini yakni bagaimana perkembangan industri halal di perdagangan global. Penelitian ini bersifat penelitian kepustakaan (library research) dengan metode tematik. Data primer dalam penelitian ini yakni data yang diperoleh langsung dari sumber utama yaitu literatur-literatur yang membahas tentang industri halal di perdagangan global. Hasil dari penulisan ini menunjukkan bahwa Industri halal di perdagangan global mengalami perkembangan secara signifikan di setiap negara muslim, bahkan di negara non muslim sekalipun. Setiap negara memiliki lembaga dan regulasi khusus yang mengurusi sertifikasi halal terhadap suatu produk. Dan terus melakukan edukasi perbaikan kualitas sumber daya manusia. Saat ini halal menjadi tren global, banyak negara yang berlomba-lomba menjadi pusat industri halal dunia.
Block Copolymer-based Photonic Pigments: Towards Structural Non-iridescent Brilliant Coloration
Authors: Steiner Ullrich , Dodero Andrea
Published: April 2023

Creating color through the self-assembly of specific building blocks to fabricate photonic morphologies is a promising and intriguing approach to reproducing the flamboyant visual effects and dynamic properties observed in the natural world. However, the complexity and lack of robustness in the manufacture of these nanostructured materials hinder their technical exploitation on a large scale. To overcome such limitations, here we present a novel methodology to create bioinspired photonic pigments as dispersed and micrometer-scale particles based on highly ordered concentric lamellar microspheres made of block copolymers. First, we introduce the fabrication protocol and the advantages of this approach compared to the traditional colloidal self-assembly. Then, we discuss some possible future research directions focused on developing hybrid organic-inorganic photonic pigments with enhanced dielectric contrast, reduced scattering, and specific functionalities. Finally, we speculate on possible applications for these structures that go beyond their use as simple photonic pigments.
Graph Neural Network Guided Evolutionary Search of Grain Boundaries in 2D Materials
Authors: Zhang Jianan , Koneru Aditya , Sankaranarayanan Subramanian , Lilley Carmen
Published: April 2023

Grain boundaries (GBs) in two-dimensional (2D) materials are known to dramatically impact material properties ranging from the physical, chemical, mechanical, electronic, and optical to name a few. Predicting a range of physically realistic GB structures for 2D materials is critical to exercising control over their properties. This, however, is non-trivial given the vast structural and configurational (defect) search space between lateral 2D sheets with varying misfits. Here, in a departure from traditional evolutionary search methods, we introduce a workflow that combines the Graph Neural Network (GNN) and an evolutionary algorithm for the discovery and design of novel 2D lateral interfaces. We use a representative 2D material, blue phosphorene (BP), and identify 2D GB structures to test the efficacy of our GNN model. The GNN was trained with a computationally inexpensive machine learning bond order potential (Tersoff formalism), and density functional theory (DFT). Systematic downsampling of the training datasets indicates that our model can predict structural energy under 0.5% mean absolute error with sparse (< 2000) DFT generated energy labels for training. We further couple the GNN model with a multi-objective genetic algorithm (MOGA) and demonstrate strong accuracy in the ability of the GNN to predict GBs. Our method is generalizable, material agnostic, and is anticipated to accelerate the discovery of 2D GB structures.
Electrochemical Dearomatizing Spirolactonization and Spiroetherification of Free Arenols
Authors: Sarvi Beigbaghlou Somayyeh , Yafele Robert S. , Kalek Marcin
Published: April 2023

An electrochemical oxidative ortho-dearomatization of naphthols and phenols with an intramolecular C–O bond formation has been developed. A careful optimization of the reaction parameters allowed for the application of free arenols as the starting materials, in contrast to the existing alternative procedures necessitating aryl methyl ethers substrates. The reaction delivers an array of spirolactones and spiroethers in yields up to 97%, under simple experimental conditions: in a constant current mode, using an undivided cell, and without an inert atmosphere. The method avoids using catalysts or stoichiometric oxidants (e.g., hypervalent iodine reagents), generating hydrogen as the sole side-product.
Expanding the Scope of Hypervalent Iodine Reagents in the Synthesis of Sulfinamides from Sulfenamides
Authors: Lu Xunbo , Huang Guoling , Ye Jianlin , Bashir Muhammad Adnan , Chen Yuetong , Chen Wenjing
Published: April 2023

This study presents a novel, efficient method for the synthesis of sulfinamidines via oxidative amination of sulfenamides using diacetoxyiodobenzene (PhI(OAc)2) and secondary amines under basic conditions. The technique achieves outstanding yields of up to 99%, streamlining the process under mild and metal-free conditions. In addition, two possible pathways are proposed to explain the observed molecular sequence of events in this reaction. The advanced approach expands the synthetic toolbox available to chemists, enabling the synthesis of valuable sulfinamidine compounds, and opening up potential applications in medicinal chemistry. Overall, this study highlights the potential of hypervalent iodine-mediated methods for efficient and streamlined organic synthesis.
Solvation of furfural at metal|water interfaces: Implications for aqueous phase hydrogenation reactions
Authors: Liu Sihang , Vijay Sudarshan , Xu Mianle , Cao Ang , Prats Hector , Kastlunger Georg , Heenen Hendrik , Govindarajan Nitish
Published: April 2023

Metal|water interfaces are central to understanding aqueous phase heterogeneous catalytic processes. However, it is challenging to model the interactions between metal surfaces, adsorbates and the solvent water molecules at the interface. Herein, we use ab-initio molecular dynamics (AIMD) simulations to study the adsorption of furfural, a platform biomass chemical on several catalytically relevant metal|water interfaces (Pt, Rh, Pd, Cu and Au) at low coverages. We find that furfural adsorption is destabilized on all the metal|water interfaces compared to the metal|vacuum interfaces considered in this work. This destabilization is a result of the energetic penalty associated with the displacement of water molecules near the surface upon adsorption of furfural. This is evidenced by a linear correlation between solvation energy and the change in surface water coverage. To predict solvation energies without the need for computationally expensive AIMD simulations, we demonstrate OH binding energy in vacuum to be a good descriptor to estimate the solvation energies of furfural on different metal|water interfaces. Using microkinetic modeling, we further explain the origin of the activity for furfural hydrogenation on intrinsically strong-binding metals, such as Rh and Pt, under aqueous conditions, i.e., the endothermic solvation energies for furfural adsorption helps prevent surface poisoning. Our work sheds light on the development of active aqueous-phase catalytic systems via rationally tuning the solvation energies of reaction intermediates.
ChatGPT Needs a Chemistry Tutor Too
Authors: Leon Alfredo , Vidhani Dinesh
Published: April 2023

AI and ChatGPT technology have the potential to revolutionize the education sector, and this study aimed to evaluate if prompt formats, response consistency, and reliability of ChatGPT responses could help colleges make the most of this technology. The results of this study can guide future AI and ChatGPT implementations and ensure they are used to their fullest potential. The data does not demonstrate a statistically significant difference between multiple-choice and free response prompt formats. Neither format achieved scores higher than 37%, and testing different locations did not improve scores. Interestingly, ChatGPT's free version provides accurate responses to discipline-specific questions that contain information from unrelated topics, improving its accuracy over the free response questions. However, it's important to remember that while ChatGPT can identify the correct answer within a given context, it may not be able to tell if the answer it chooses is correct computationally or through analysis.
Effect of FEC electrolyte additive on the electrochemical performance of nickel-rich NCM ternary cathode
Authors: She Shenxian , Zhou Yangfan , Hong Zijian , Huang Yuhui , Wu Yongjun
Published: April 2023

It has been well established recently that fluorinated electrolyte additives such as Fluoroethylene carbonate (FEC) could promote the formation of LiF-based solid electrolyte interphase that can stabilize lithium metal anode. Meanwhile, the impact of FEC additive on the cathode side, particularly for the high energy density nickel-rich LiNi1-x-yCoxMnyO2 (NCM) ternary cathodes, remains unclear. In this study, we investigated the structural and chemical composition of cathode electrolyte interphase (CEI) and its electrochemical performance to elucidate the effect of FEC additive on the LiNi0.9Co0.05Mn0.05O2 (NCM90) cathode for high energy lithium-ion batteries. It is discovered that the FEC additive in carbonate electrolyte (BE-FEC) can produce LiFbased CEI, which could stabilize the NCM90 surface and improve the cycle performance at low cut-off voltage. While the formation of a thick LiF layer under high cut-off voltage and high rate leads to a higher polarization and slower Li+ transport kinetics, which in turn deteriorates the battery performance. Whereas in carbonate electrolyte (BE), under low voltage, the unstable Li2CO3-based amorphous CEI components form on the NCM90 surface while an intermediate rock salt structure can also be identified, leading to poor cycle life. While under high voltage, the BE sample shows superior electrochemical performance due to the formation of a thin LiF layer from the decomposition of the LiPF6. Our work provides a comprehensive understanding of the role of FEC in the CEI of nickel-rich cathodes, offering practical guidance for the design of electrolytes for high-energy nickel-rich cathodes.
Influence of precursor structure on the formation of tungsten oxide polymorphs
Authors: Juelsholt Mikkel , Aalling-Frederiksen Olivia , Lindahl Christiansen Troels , Kjær Emil T. S. , Lefeld Niels , Kirsch Andrea , Jensen Kirsten M. Ø.
Published: April 2023

Understanding material nucleation processes is crucial for the development of synthesis pathways for tailormade materials. However, we currently have little knowledge of the influence of the precursor solution structure on the formation pathway of materials. We here use in situ total scattering to show how the precursor solution structure influences which crystal structure is formed during the hydrothermal synthesis of tungsten oxides. We investigate the synthesis of tungsten oxide from the two polyoxometalate salts, ammonium metatungstate and ammonium paratungstate. In both cases, a hexagonal ammonium tungsten bronze (NH4)0.25WO3, is formed as the final product. If the precursor solution contains metatungstate clusters, this phase forms directly in the hydrothermal synthesis. However, if the paratungstate B cluster is present at the time of crystallization, a metastable intermediate phase in the form of a pyrochlore-type tungsten oxide, WO30*5H2O, initially forms. The pyrochlore structure then undergoes a phase transformation into the tungsten bronze phase. Our studies thus experimentally show that the precursor cluster structure present at the moment of crystallization directly influences the formed crystalline phase and suggest that the precursor structure just prior to crystallization can be used as a tool for targeting specific crystalline phases of interest.
Depresyon tanısı alan hastalara uygulanan bilişsel davranışçı terapide psikiyatri hemşiresinin rolü: Literatür incelemesi
Authors: ALTUNDAL DURU Hilal , YILMAZ Mualla
Published: April 2023

Depresyon, bireyin nasıl hissettiğini, düşündüğünü ve davrandığını etkileyen; üzüntü duyulan duygulara veya zevk alınan etkinliklere olan ilginin kaybolmasına neden olan yaygın ve ciddi bir tıbbi durumdur. Depresyonda sıklıkla kullanılan psikoterapi yöntemi Bilişsel Davranışçı Terapi’dir (BDT). İlk kez 1964’te Aaron Temkin Beck tarafından ortaya atılan BDT, çeşitli duygusal ve davranışsal problemlerin tedavisinde etkinliği yaygın biçimde araştırılan bir model olup, işlevsiz duygular, davranışlar ve bilişlerle ilgili sorunları hedefe yönelik, sistematik bir prosedürle çözmeyi amaçlayan psikoterapötik bir yaklaşımdır. Bu psikoterapötik yaklaşımda sertifikalandırılmış psikiyatri hemşireleri de yer alabilmektedir. Psikiyatri hemşireleri danışmanlık rolleri gereği; bireye baş etme becerileri kazandırma, yeti yitimlerini en aza indirme, ruh sağlığını koruma ve geliştirmede önemli bir görev üstlenmektedir. Sertifikalandırılmış psikiyatri hemşireleri, ruh sağlığını koruma ve geliştirme, ruhsal hastalık ve sakatlığı önleme, bireyin işlevselliğini ve fonksiyon yetersizliğini hastalık öncesi durumuna getirmede psikoterapist rolünü kullanarak birey, aile ve gruplara psikoterapi uygulayabilmektedir. BDT'nin fiziksel sağlık ortamlarında kanıtlarının arttığı göz önüne alındığında, psikiyatri hemşireleri gelecekte artan beklentilere cevap vermek için; kanıta dayalı tedavi, kalite iyileştirme ve artan verimliliği BDT ile sağlayabilecektir. Dolayısıyla bu derlemenin amacı, depresyon tanısı alan hastalara uygulanan BDT’nin etkinliğinin güncel araştırma sonuçlarıyla derlenerek, psikiyatri hemşireliğine yansımalarını incelemektir. Bu derleme ile depresyon tanılı hastalarda BDT kullanımının psikiyatri hemşireliği uygulamaları kapsamında yürütülmesine katkı sağlayacağı düşünülmektedir.
Orak hücre hastalarında görülen ağız, diş ve çene bölgesi ile ilgili komplikasyonlar hakkında ebeveyn bilgi düzeyinin değerlendirilmesi
Authors: KARAHAN Feryal , YILMAZ Melis
Published: April 2023

Amaç: Orak hücre hastalığı (OHH), hastaların yaşam kalitelerini hayatlarının erken dönemlerinden itibaren etkileyen multisistemik bir hastalıktır. Çalışmamızın amacı; OHH hastalarımızın primer bakım veren ebeveyninin (anne) OHH’a bağlı ağız, diş ve çene bölgesinde gelişen komplikasyonlar ile ilgili bilgi düzeyini değerlendirmektir. Yöntem: Çalışmaya çocuk ve genç erişkinlerden oluşan 50 OHH tanılı hasta ile primer bakım veren ebeveynleri dahil edildi. Ebeveynlere anket uygulanarak OHH’da ağız, diş sağlığı konusundaki bilgi düzeyleri ve çocuklarının ağız, diş, çene bölgesinde deneyimlediği klinik belirtiler sorgulandı. Bulgular: Ebeveynin bilgi düzeyi değerlendirildiğinde; 28’i (%56) OHH’nın ağız, diş, çene sağlığına etkisi olduğunu belirtti. Günde bir kez diş fırçalayan hastalarda hiç fırçalamayanlara göre damar tıkayıcı kriz (DTK) sıklığının daha nadir (%5’e karşı %58), günde ≥2 diş fırçalayanların ise hiç fırçalamayanlara göre transfüzyon sıklığının daha az (%6’ya karşı %32) olduğu saptandı. Sonuç: Çalışmamız; ebeveynlerin %44’ünün OHH’nın ağız, diş ve çene bölgesindeki komplikasyonları bilmediğini gösterdi. Ayrıca diş fırçalamanın DTK ve kan transfüzyon sıklığına etkisi olabileceğini saptadık. Ağız, diş hijyeninin önemi ile OHH’nın bu bölgedeki komplikasyonları konusunda hastaların ve ebeveynlerin farkındalığı artırılmalıdır.
Hemşirelerin aşı karşıtlığı düzeylerinin belirlenmesi
Authors: GÜNEŞ Hüseyin , SEMERCİ Vahide , KIRBAŞ Zila Özlem
Published: April 2023

Amaç: Bu çalışma hemşirelerin aşı karşıtlığı düzeylerinin belirlenmesi amacıyla yapıldı. Yöntem: Çalışma 15 Eylül-30 Eylül 2022 tarihleri arasında bir eğitim araştırma hastanesinde tanımlayıcı olarak yapıldı. Örneklem seçimine gidilmeyip çalışmaya katılmayı kabul eden, çalışma tarihlerinde izinli ve raporlu olmayan 282 hemşireye ulaşıldı. Veriler Kişisel Bilgi Formu ve Aşı Karşıtlığı Ölçeği kullanılarak hemşireler ile yüz yüze görüşülerek toplandı. Bu çalışmada bilimsel ve evrensel ilkelere uyuldu ve gerekli izinler alındı. Veriler IBM SPSS v25 paket programda analiz edildi. İstatistiksel anlamlılık düzeyi p<0.05 olarak kabul edildi. Veriler normal dağıldığından hemşirelerin tanıtıcı özellikleri ile ölçek puanlarının karşılaştırmasında Independent Sample T testi ve One-Way ANOVA testi kullanıldı. Bulgular: Çalışmaya katılan hemşirelerin yaş ortalaması 39.60±7.43 (min=20, max=59)’tür. Hemşirelerin %90.8’i kadın olup, %83.3’ü evli, %72.0’si lisans mezunu ve %62.1’i servis hemşiresi olarak çalışmaktadır. Hemşirelerin Aşı Karşıtlığı Ölçeği toplam puanı 46.82±12.43’tür (min=21, max=90). Aşı Karşıtlığı Ölçeği toplam puanı ile hemşirelerin aşı tereddütü yaşamaları, çocuk sahibi olma durumları ve aşı hakkında bilgi durumları arasında istatistiksel olarak anlamlı fark bulundu (p<0.05). Sonuç: Çalışmamızda hemşirelerin aşı karşıtlığı orta düzeydedir. Aşı tereddütü yaşayan ve akrabasından/arkadaşından aşı hakkında bilgi edinen hemşirelerin Aşı Karşıtlığı Ölçeği toplam puanı daha yüksek, çocuk sahibi olan hemşirelerin Aşı Karşıtlığı Ölçeği toplam puanı daha düşüktür.
Erken postpartum dönemde kadınların aile planlamasına yönelik tutumu ve etkileyen faktörler
Authors: TURAN Zeliha , KORUK Fatma
Published: April 2023

Amaç: Postpartum dönem, kadınların aile planlaması yöntem kullanımı konusunda isteklerinin yüksek olduğu bir dönem olması bakımından, doğurganlığın planlanması ve bu konuda bireylere hizmet sunulabilmesi açısından iyi bir fırsattır. Kadınların hastaneden taburcu olmadan önce kullanacakları aile planlaması yöntemine karar vermiş olmaları plansız ya da istenmeyen gebeliklerin önlenmesi açısından oldukça önemlidir. Bu araştırmada, erken postpartum dönemdeki kadınların aile planlamasına yönelik tutumları ve etkileyen faktörleri belirlemek amaçlanmıştır. Yöntem: Kesitsel tipte yapılan araştırmanın örneklemini, bir kamu hastanesinin postpartum kliniklerinde yatan 243 kadın oluşturmuştur. Araştırma verileri Haziran-Temmuz 2022 tarihleri arasında toplanmıştır. Bulgular: Çalışmada, kadınların yaş ortalaması 28.17±5.42 ve çocuk sayısı ortalaması 3.51±1.89’dur. Ayrıca, kadınların %46.5’i okur-yazar değildir ve %73.7’si tekrar çocuk istemektedir. Kadınların aile planlaması tutum ölçeği puan ortalaması 90.8±8.10’dir. Eğitim düzeyi daha yüksek, il merkezinde yaşayan ve gebelik izlemlerini özel hastanede yaptıran kadınların aile planlaması tutum ölçeği puan ortalamasının daha yüksek olduğu; kendi yaşı ve eşinin yaşı, evlenme yaşı ve ilk gebelik yaşı daha fazla olan kadınlar ile tekrar çocuk isteyen kadınların ise aile planlaması tutum ölçeği puan ortalamasının daha düşük olduğu belirlenmiştir (p<0.05). Sonuç: Araştırma, erken postpartum dönemde kadınların aile planlamasına karşı tutumlarının olumlu olduğunu ancak istendik düzeyde olmadığını göstermiştir.
An analysis of human resource practices: A comparison between the hospitality industry and other sectors
Authors: Nitin S. , Ramesh R. , Joseph K.
Published: April 2023

The success of public and private sector organizations is largely determined by the knowledge, skills, and motivation of their workforce. The private sector currently dominates the provision of services, accounting for 70% of services provided. Within the private sector, the hospitality industry is particularly dependent on a multidisciplinary workforce with various categories of employees. Supervisory staff, middle management, and senior executives all play crucial roles in ensuring the provision of high-quality hospitality services. Effective personnel management is essential to ensure that the qualitative and quantitative needs of different departments are met. However, the hospitality industry operates in a dynamic and complex environment, which can lead to challenges such as lower occupancy rates, higher capacity, shorter guest stays, and negative impacts on the hotel's reputation. Therefore, the quality of care provided to guests is of utmost importance in the hospitality industry, as it can directly affect business growth and performance. Adequate guest care and preferences must be taken into account, and strategies should be in place to ensure that the hospitality services meet guests' needs and preferences.
Study of the expression of oncoprotein p53, EGFR in colorectal carcinomas with different proliferative activity
Authors: Shponka I.S. , Kharkhalis I.K. , Poslavska O.V.
Published: April 2023

Colorectal cancer, according to the International Agency for Research on Cancer, was and remains an urgent problem worldwide. In 2020, in Ukraine, morphological verification of new cases of colon and rectal cancer was carried out at a high level (83.2% and 89.5%, respectively), but despite this, specific treatment covered only 69.4% and 74.5% of eligible patients, that is why about a third of patients (30.8% of colon cancer patients and 25.0% of rectal cancer patients) did not live even a year from the moment of its detection in 2020. The aim of the study was to evaluate the prognostic significance of the expression of p53 and EGFR markers depending on the clinical, morphological characteristics and proliferative activity of colorectal carcinomas. The clinical and anatomical material of 37 patients (15 women and 22 men) was studied in the work. The age of the patients ranged from 27 to 82 years; the average age was 61.43±14.90 years. Antibodies to Ki-67, p53, EGFR and the UltraVision Quanto visualization system (LabVision) were used for immunohistochemical research. Digital morphometry was performed in the Fiji platform with the calculation of percentages of p53 and Ki-67-positive intranuclear reactions with the ImmunoRatio plugin. The distribution of p53 expression variants - wild type (0<p53 <10%) or "mutant" (overexpression ≥10% or completely negative samples) showed no significant difference in any group (all p>0.05), despite that among men, mutant expression of p53 was significantly higher than among women – 72.72% (16 out of 22) versus 53.33% (8 out of 15), and all patients under the age of 50 years had a mutant type of p53 expression 9 out of 9 (100%), while the number of such observations after 50 years already decreased to about half – 15 out of 28 (53.57%). The distribution of EGFR expression variants showed a significant difference in subgroups according to grade (p<0.05) and in subgroups with different proliferative potential according to Ki-67 (p<0.05).
Problems of physical rehabilitation of movement disorders in the pathology of the hip joint in patients with the consequences of a cerebral stroke
Authors: Shkurupіi О.І. , Olexenko І.М. , Smirnova О.L. , Gryshunina N.Y. , Yaroshenko K.O.
Published: April 2023

The purpose of the work was to analyze the experience of foreign specialists regarding movement and structural disorders of the proximal part of the femur in patients with the consequences of stroke and their impact on the effectiveness of rehabilitation programs for hip joint pathology. To fulfill the goal, an analysis of foreign literary sources was carried out in modern databases: Google Scholar, Web of Science, PubMed, Medline, Cochrane, Pedro. The search depth is 22 years (from January 2000 to October 2021). The analysis of literature sources indicated that limitation of motor activity and axial loads in patients after acute cerebrovascular accident, in particular limitation of mobility in the hip joint, impairment of muscle strength and tone due to hemiparesis can lead to the development of osteoporosis. Particularly important from the point of view of adverse consequences is a decrease in mineral density and fractures of the proximal part of the femur. On the other hand, disturbed biomechanics of movements in the hip joint in persons with the consequences of a cerebral stroke, under the condition of axial load on the limb, can lead to the development of osteoarthritis of the hip joint. Osteoarthritis results in limited mobility of the hip joint, which leads to secondary immobilization of the hip joint and, as a result, can also lead to further osteoporosis. Existing disorders of neuromuscular control, muscle tone and strength, limitation of mobility of the hip joint, including due to spasticity, problems with static and dynamic balance, and, as a result, an increased risk of falling in patients with the consequences of a stroke, can negatively affect the recovery of motor functions, activity limitation, and, as a result, reduce the effectiveness of rehabilitation of patients after hip joint replacement. Existing movement disorders, as a result of a stroke, require the development and justification of new rehabilitation programs, including the use of modern technical means and virtual reality.
Evaluation of the main parameters of the compartmental model of the epidemic development based on the example of the spread of the COVID-19 pandemic in Chernivtsi region
Authors: Nahirniak V.M.
Published: April 2023

The paper considers the application of the theoretical model of epidemiological development of COVID-19 disease among the regional population based on the statistical data in Chernivtsi region of Ukraine for the period from March 2020 to June 2021. Using these data, a mathematical assessment of the values of the main parameters of the compartmental model (SIR) β and γ was performed and the analysis of the relationship between the values of β and γ and antiepidemiological measures was carried out for the region. Determining the parameters β and γ based on available statistics allows us to predict the duration of precautionary measures such as quarantine, lockdown, border closure and predict the effectiveness of their implementation as well. The analysis of statistical data showed the moderate effectiveness of quarantine and lockdown in changing the daily rates of infected and recovered people, while the dynamics of the epidemic development during these periods changed from negative to positive. The introduction of vaccination has shown the significant reduction in the daily rate of infected people and the substantial increase in the daily rate of the recovered people.
ИНСТРУМЕНТЫ МОДЕЛИРОВАНИЯ БИЗНЕС-ПРОЦЕССОВ ЭНЕРГОСБЫТОВЫХ КОМПАНИЙ
Authors: Павленок Андрей Александрович
Published: April 2023

В статье предлагается метод моделирования сети бизнес-процессов энергосбытовых компаний (ЭСК), функционирующих на территории Российской Федерации (РФ). Необходимость совершенствования методов и инструментов управления энергокомпаниями определяется внешними условиями: внедрением новых механизмов конкуренции на энергорынках в РФ, следованию тенденциям «Энергоперехода», стимулированием внедрения цифровых решений. В наибольшей степени в настоящее время развита конкуренция на розничном рынке электроэнергии, где основными участниками являются энергосбытовые компании, поэтому актуальность повышения их конкурентоспособности не вызывает сомнений. Предлагаемый в данной статье метод моделирования сети бизнес-процессов разработан на основе процессного подхода к организации деятельности предприятий и учитывает особенности энергосбытовой деятельности. Метод позволяет выделять основные бизнес-процессы энергосбытовой компании, которые требуют первоочередного управления для повышения конкурентоспособности ЭСК. Приоритезация и дальнейший реинжиниринг бизнес-процессов ЭСК должны опираться на структурирование бизнес-процессов по этапам организационного развития, так как цели и задачи, стоящие перед ЭСК, значительно отличаются в зависимости от этапа развития организации. Использование предлагаемого метода позволит ЭСК в дальнейшем внедрять бизнес-процессы, необходимые для получения конкурентных преимуществ на рынках электрической энергии (мощности), соответствующие ключевым факторам успеха энергосбытовой деятельности в условиях трансформации энергорынков.
UJI AKTIVITAS PENANGKAPAN RADIKAL BEBAS DPPH OLEH EKSTRAK ETANOL DAUN PISANG TANDUK (MUSA PARADISIACA VAR. FORMATYPICA) DAN DAUN PISANG CAVENDISH (MUSA PARADISIACA VAR. SAPIENTUM)
Authors: Nugraheni Tiyas Putri , Rosvita Vivin , Pratiwi Husnun Khairunnisa
Published: April 2023

AbstractHas done research about free radical scavenging activity of ethanolic extract Musa paradisiaca var formatypica and Musa paradisiaca var sapientum leaf. Banana leaf contain phenolic compunds, flavonoids, alkaloids, tannin, and saponin as a free radical scavenging.Extracts were prepared by maceration method using ethanol 70% as solvent. DPPH free radical scavenging activity was performed by spectrophotometry visible to extracts with quercetin as the comparison. The free radical scavenging activity was expressed by percent reduction and ES50.Study result showed that ethanol extract of banana leaf and Cavendish leaf containing flavonoids, polyphenols, tannins, saponins, terpenoids and had antioxidant activity also DPPH free radical scavenging activity. The ES50 value ethanol extract of banana leaf is 104.36 (µg / ml), ethanol extract of Cavendish leaf is 157.36 (µg / ml), whereas quercetin is 2.86 (µg / ml).Statistical analysis result showed a significant difference between percent of free radical scavenging activity of quercetin, banana leaf extract and Cavendish leaf extract.Keywords: Free radical, antioxidant, extract banana leaf, extract cavendish leaf AbstrakTelah dilakukan penelitian tentang aktivitas penangkapan radikal bebas oleh ekstrak etanol daun pisang Tanduk dan daun pisang Cavendish. Daun pisang mengandung golongan senyawa fenolik, flavonoid, alkaloid, tannin, dan saponin yang berpotensi sebagai penangkal radikal bebas.Ekstrak dibuat dengan metode maserasi menggunakan pelarut 70%. Uji penangkapan radikal bebas DPPH dilakukan secara spektrofotometri visibel terhadap ekstrak dengan pembanding kuersetin. Aktivitas penangkapan radikal bebas dinyatakan sebagai persen peredaman dan ES50.Hasil penelitian menunjukkan bahwa ekstrak etanol daun pisang Tanduk dan ekstrak etanol daun pisang Cavendish mengandung senyawa flavonoid, polifenol, tanin, saponin, terpenoid, serta mempunyai aktivitas sebagai antioksidan dan penangkap radikal bebas DPPH. Ekstrak etanol daun pisang Tanduk mempunyai nilai ES50 sebesar 104,36 (µg/ml), ekstrak etanol daun pisang Cavendish memiliki nilai ES50 sebesar 157,36 (µg/ml), sedangkan standar kuersetin mempunyai nilai ES50 sebesar 2,86 (µg/ml).Hasil analisis statistik menunjukkan adanya perbedaan yang bermakna antara persen penangkapan radikal bebas kuersetin, ekstrak daun pisang Tanduk, dan ekstrak daun pisang Cavendish.Kata Kunci: Radikal bebas, antioksidan, ekstrak daun pisang tanduk, ekstrak daun pisang cavendish
FORMULASI TABLET HISAP EKSTRAK DAUN KETEPENG CINA (CASSIA ALATA L.) DENGAN PENGISI MANITOL DAN PENGIKAT CMC–NA
Authors: Murharyanti Rika , Renowati Eko , Jaya Trisdian Hadi
Published: April 2023

Penggunaan yang terlalu sering dan kurang tepat dari antibiotik dapat menimbulkan resistensi bakteri, sehingga dibutuhkan alternatif baru untuk obat antimikroba. Ketepeng cina (Cassia alata L.) merupakan salah satu tanaman obat yang dilaporkan memiliki aktivitas antimikroba dan berkhasiat imunomodulator karena adanya flavonoid yang terkandung didalamnya. Tujuan dari penelitian ini adalah untuk menentukan formula ideal tablet hisap ekstrak daun ketepeng cina, menggunakan pengisi manitol dan pengikat CMC-Na. Pembuatan tablet hisap ekstrak daun ketepeng cina dengan kadar CMC-Na 1%, 2%, dan 3% dilakukan dengan metode granulasi basah. Hasil analisis statistik one way anova dengan program SPSS pada tingkat kepercayaan 95%, dilanjutkan dengan Tukey HSD untuk menunjukkan adanya perbedaan yang bermakna pada mutu fisik tablet dari masing-masing formula terhadap peningkatan kadar bahan pengikat CMC-Na. Sehingga dapat disimpulkan bahwa semakin tinggi kadar pengikat CMC-Na memiliki pengaruh terhadap mutu fisik tablet hisap ekstrak daun ketepeng cina.
UJI EFEKTIFITAS SEDIAAN KRIM GETAH POHON KAMBOJA MERAH (Plumeria Rubra) TERHADAP LUKA AKIBAT SAYATAN PADA TIKUS JANTAN PUTIH WINSTAR HIPERGLIKEMI
Authors: Retnowati Eko , Mundriyastutik Yayuk , Hamid Abdul
Published: April 2023

AbstrakLatar Belakang : Getah kamboja dengan dosis yang tepat dapat dimanfaatkan sebagai antiseptik yang bermanfaat untuk perawatan luka. Getah kemboja terkandung alkaloid, tanin, flavonoid dan tripterpenoid. Flavonoid merupakan komponen senyawa kimia yang terdapat pada getah kamboja yang diduga sebagai antibakteri. Namun demikian, pemanfaatan tanaman kamboja, khususnya getah dari bagian batang tanaman kamboja belum dimanfaatkan sebagai bahan perawatan luka. Tujuan : Untuk mengetahui efektivitas sediaan krim getah pohon kamboja merah (Plumeria rubra) terhadap luka akibat sayatan pada tikus jantan putih diabetes. Metode : Penelitian ini merupakan penelitian eksperimental laboratorium menggunakan desain penelitian posttest-only control design.  Hasil Penelitian : Pemberian krim dari getah kamboja dengan konsentrasi 30% memberikan efek penutupan luka sayat paling cepat waktu penyembuhan diperoleh hasil dihari yang ke 9 karena luka sudah menyusut dengan cepat dibandingkan pada konsentrasi 10% yang mengalami kesembuhan pada hari ke-21 , konsentrasi 20% dengan kesembuhan pada hari ke-17, sementara pada kontrol negatif dan positif pada hari ke 25.  Kesimpulan :  Evektifitas sediaan krim getah pohon kamboja merah lebih baik pada konsentrasi 30% dibandingkan dengan konsentrasi 10%, konsentrasi 20%, kontrol negatif dan kontrol positif Saran : Hasil penilitian diharapkan dapat menambah informasi mengenai manfaat getah kamboja merah dan dilakukan penelitian lagi dengan menggunakan konsentrasi yang berbeda.Kata Kunci: Krim getah kamboja merah (plumeria rubra), tikus jantan putih diabetes, luka sayat
UJI AKTIVITAS ANTIOKSIDAN DAN KADAR FLAVONOID TOTAL PADA EKSTRAK ETANOL BIJI DAN KULIT MELINJO (GNETUM GNEMON L.) DENGAN METODE DPPH
Authors: Hasriyani Hasriyani , Akhyasin Akhyasin , Dikdayani Latifah
Published: April 2023

Latar Belakang: Salah satu tanaman yang diketahui memiliki aktivitas antioksidan adalah tanaman melinjo (Gnetum gnemon L.). Pada tumbuhan melinjo (Gnetum gnemon L.) terdapat berbagai macam senyawa metabolit sekunder. Senyawa tersebut dapat berfungsi sebagai bahan obat tradisional. Senyawa metabolit sekunder tersebut diantaranya alkaloid, flavonoid, saponin, tanin.Tujuan: Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan dan kadar flavonoid total pada biji dan kulit melinjo (Gnetum gnemon L.) dengan metode DPPH.Metode: Metode yang digunakan dalam penelitian ini yaitu pendekatan kuantitatif. Analisis kuantitatif yaitu untuk mengetahui uji aktivitas antioksidan dan kadar flavonoid total pada ekstrak etanol biji dan kulit melinjo (Gnetum gnemon L.) dengan metode DPPH (2,2-diphenyl-1-picrylhydrazyl).Hasil: Hasil penelitian menunjukkan bahwa ekstra etanol untuk biji dan kulit melinjo memiliki aktivitas antioksidan yang baik. Hasil uji kuantitatif antioksidan yang diperoleh nilai IC50 pada ekstrak etanol biji melinjo 0,043 µg/mL dan kulit melinjo 0,121 µg/mL. Untuk hasil dari uji kuantitatif kadar senyawa flavonoid pada biji melinjo sebesar 1,26 mgQE/gram sedangkan pada kulit melinjo diperoleh kadar sebesar 1,37 mgQE/gram.Kesimpulan: Ekstrak biji dan kulit melinjo menunjukkan adanya aktivitas antioksidan yang memiliki kategori sangat kuat. Ekstrak kulit melinjo memiliki kadar flavonoid total lebih tinggi dari pada ekstrak biji melinjo.Kata Kunci: Biji Melinjo, Kulit Melinjo, Ekstrak Etanol, Antioksidan, DPPH.
SUPLEMENTASI MIKROMINERAL, VITAMIN DAN JUS MENGKUDU TERHADAP KOLESTEROL DAN TRIGLISERIDA TELUR PUYUH
Authors: Kurnia Shinta Dwi , Saraswati Tyas Rini , Isdadiyanto Sri
Published: April 2023

Telur puyuh mempunyai kandungan kolesterol yang tinggi. Resiko mengkonsumsi makanan dengan kandungan kolesterol tinggi sudah diketahui oleh masyarakat. Penelitian ini bertujuan untuk mengetahui potensi mikromineral (Fe, Co, Cu, Zn), vitamin (A, B1, B12, C) dan jus mengkudu dalam rangka pemeliharaan untuk meningkatkan karakteristik kualitas kimiawi melalui kadar kolesterol dan trigliserida pada telur puyuh. Hewan coba yang digunakan dalam penelitian ini adalah puyuh Jepang (Coturnix coturnix japonica L.) dengan jumlah 60 ekor puyuh betina umur 2 minggu. Penambahan mikromineral, vitamin dan jus mengkudu pada air minum yang diberikan secara ad libitum. Puyuh dibagi menjadi 4 kelompok percobaan dengan 5 ulangan masing-masing perlakuan terdiri dari 3 ekor puyuh, yaitu kontrol (P0), mikromineral dan vitamin (P1), jus mengkudu (P2), dan campuran ketiganya (P3). Data yang diperoleh diolah menggunakan Analysis of Varian (ANOVA) dengan dasar rancangan acak lengkap. Hasil penelitian menunjukkan bahwa pemberian larutan mikromineral, vitamin dan jus mengkudu mampu menurunkan kadar kolesterol dan trigliserida telur puyuh secara nyata. Kata Kunci: telur puyuh, mikromineral, vitamin, mengkudu
PERBANDINGAN EFEKTIVITAS PENURUNAN TEKANAN DARAH DENGAN PEMBERIAN KOMBINASI AMLODIPIN DENGAN KAPTOPRIL DAN AMLODIPIN DENGAN LISINOPRIL PADA PASIEN HIPERTENSI DI RUMAH SAKIT PKU MUHAMMADIYAH MAYONG JEPARA
Authors: Setyowati Endang , Prayitno Ezara Mila Fawwazah , Mundriyastutik Yayuk , Isnaeni Ratna Dewi
Published: April 2023

Hypertension is a non-communicable disease as well as one of the mortality factors in the world with a prevalence of 22% of the world's population. According to riskesdas, the prevalence of hypertension in Indonesia increased by 8.3% and 8.2% per year 2018. The selection and treatment of hypertension also requires the use of effective drugs and can provide good tolerance. The effectiveness as well as the benefits in the treatment of hypertension race on the measurement of blood pressure that has reached the target. The drop in blood pressure can also be influenced by the rational use of drugs both monotherapy and in combination. The purpose of this study was to analyze the comparison of the effectiveness of the use of drugs combination of amlodipine with captopril and amlodipine with lysinopril. This research method includes qualitative research using the cross sectional method with a retrospective approach. The results of the independent t-test of the significance value of the systolic category are 0.781>0.05 and the significance value of the diastolic category is 0.923>0.05. Pacidists who received combination therapy of amlodipine-captopril and amlodipine-lisinopril who achieved the targetse number of 43 patients. After independent t-test before and after therapy, it can be concluded that both the systolic category and the diastolic category regarding the effectiveness of the two combinations have no significant differences and the amlodipine-lysinopril combination is more effective in achieving the target of lowering blood pressure than amlodipine-captopril