bluuebunny/crossref_metadata_2025 huggingface dataset:
Modelling and analysing biological oscillations in quorum sensing networks
Authors: Chen Menghan , Liu Haihong , Yan Fang
Published: April 2020

Recent experiments have shown that the biological oscillation of quorum sensing (QS) system play a vital role not only in the process of bacterial synthesis but also in the treatment of cancer by releasing drugs. As known, these five substances TetR, CI, LacI, AiiA and AI are the core components of the QS system. However, the effects of AiiA and protein synthesis time delay on QS system are often ignored in the theoretical model, which is taken as a priority in the proposed research. Therefore, the authors developed a new mathematical model to explore the effects of AiiA and time delay on the dynamical behaviour of QS system theoretically and numerically. The results show that time delay can induce oscillation of QS system. Concretely, there exists a time delay threshold . When time delay is less than , the system is stable. With the increasing of time delay and once it passes , oscillation behaviour occurs. Moreover, the length of time delay determines the amplitude and period of the QS oscillation. In addition, the value of is sensitive to AiiA. These results may enhance the understanding of QS oscillations and provide new insights for bacterial release drugs to treat cancer.
Optimal control of stochastic phase-field models related to tumor growth
Authors: Orrieri Carlo , Rocca Elisabetta , Scarpa Luca
Published: April 2020

We study a stochastic phase-field model for tumor growth dynamics coupling a stochastic Cahn-Hilliard equation for the tumor phase parameter with a stochastic reaction-diffusion equation governing the nutrient proportion. We prove strong well-posedness of the system in a general framework through monotonicity and stochastic compactness arguments. We introduce then suitable controls representing the concentration of cytotoxic drugs administered in medical treatment and we analyze a related optimal control problem. We derive existence of an optimal strategy and deduce first-order necessary optimality conditions by studying the corresponding linearized system and the backward adjoint system.
Elemental dynamics in porewater of an acid sulfate paddy soil as affected by sodium bentonite and dolomite amendments: insights from field study
Authors: Wongleecharoen Chalermchart , Wisawapipat Worachart , Ketrot Daojarus , Chittamart Natthapol , Aramrak Surachet , Chittanukul Kittipon , Sattapun Rachit , Tawornpruek Saowanuch
Published: April 2020

Rice productivity in acid sulfate soils are frequently limited due primarily to strong acidity, low phosphorus (P) availability and metal toxicity. A recent study has documented that the use of sodium bentonite (NaB), non-hazardous material uses in natural gas pipeline construction, could be a promising soil amendment for mitigating major concerns experiencing in acid sulfate soils. Here we examined the effects of NaB and dolomite (DL) on dynamics in dissolved contents of both nutrient and associated elements in an acid sulfate soil and rice yield from paddy field in natural gas pipeline Rights-of-Way. The results demonstrated that the NaB and DL utilization significantly alleviated soil acidity and metal (Al, Fe, and Mn) toxicity (α = 0.05). Both soil amendments also significantly improved readily available P. Nonetheless, the soil NaB incorporation did elevate soluble sodium and did plummet soluble K, Ca, and Mg. Therefore, appropriate ratios and amounts of the K, Ca, and Mg along with N fertilizers are indisputable needed to maintain the nutrient balance when applying NaB as a soil amendment. Our finding implies that combined use of NaB and DL are suggested to soil amendment and could alleviate nutrient imbalance as compared to the sole NaB utilization.
Design and task management of a mobile solar station for charging flying drones
Authors: Ali Essam , Fanni Mohamed , Mohamed Abdelfatah M.
Published: April 2020

This paper provides design and task management of the first stage of a project entitled “Fall-Army Worm (FAW) insect killer”. The project has three main stages: design and energy management stage, flying control of drone stage and detecting and killing FAW stage. The goal of this project is to detect and kill; without chemical methods; a harmful FAW insect which is rapidly spreading in Africa and Asia. This paper focuses on design of the first stage of the system, getting maximum power and controlling the energy of the system. A Photo Voltaic system with energy storage devices is proposed to be the source of power. A new algorithm to control the time scheduling of the killing and detection mission is proposed and its effects on the system’s energy and mission period are studied. A comparison between different methods for tracking the maximum power from PV panels is performed to choose the best (less time and high accuracy) method. The results of simulation indicate the effectiveness of the proposed maximum power tracking and task management system.
Impact of emission trading and renewable energy support scheme on the optimality of generator side bidding
Authors: Arya A , Mathur SPS , Dubey M
Published: April 2020

As a major Green House Gases (GHG) producer, CO2in particular, the electricity industry’s emissions have turned in to a matter of immense concern in many countries, especially in India. India’s economy and fast economic development has attracts the attention of the world. Emission trading schemes (ETS) and renewable energy support schemes (RESS) are implemented by the various developed countries to alleviate the affect of GHG emissions. In this paper, an optimization based market simulation approach is proposed with the consideration of emission trading schemes and renewable support schemes. To simulate the bidding strategy and for profit maximization, a particle swarm optimization (PSO) algorithm is used. As above problem is a multi-objective optimization problem, Where, in the first level each Genco submit the bid to the independent system operator and in the next level a optimization method is used for the determination of optimal bidding with the implementation of emission trading schemes and renewable support schemes. It is assumed that each generator should submit bid as a price taker’s in sealed auction based on pay-as-bid market clearing price mechanism. The practicability of proposed optimization method is checked by an IEEE-30 bus test system consists of six suppliers.
Recovered finite element methods on polygonal and polyhedral meshes
Authors: Dong Zhaonan , Georgoulis Emmanuil H. , Pryer Tristan
Published: April 2020

Recovered Finite Element Methods (R-FEM) have been recently introduced in Georgoulis and Pryer [Comput. Methods Appl. Mech. Eng. 332 (2018) 303–324]. for meshes consisting of simplicial and/or box-type elements. Here, utilising the flexibility of the R-FEM framework, we extend their definition to polygonal and polyhedral meshes in two and three spatial dimensions, respectively. An attractive feature of this framework is its ability to produce arbitrary order polynomial conforming discretizations, yet involving only as many degrees of freedom as discontinuous Galerkin methods over general polygonal/polyhedral meshes with potentially many faces per element. A priori error bounds are shown for general linear, possibly degenerate, second order advection-diffusion-reaction boundary value problems. A series of numerical experiments highlight the good practical performance of the proposed numerical framework.
Nonlinear time-delay feedback controllability for vertical parametrically excited vibration of roll system in corrugated rolling mill
Authors: He Dongping , Xu Huidong , Wang Tao , Ren Zhongkai
Published: April 2020

This paper investigates vibration characteristics of the corrugated roll system and designs a time-delay feedback controller to control the parametrically excited vibration of system. The model of parametrically excited nonlinear vertical vibration of roller system is established by considering the nonlinear damping and nonlinear stiffness within corrugated interface of corrugated rolling mill. The approximate analytical solution and amplitude-frequency characteristic equations of principal resonance and sub-resonance of roller system are obtained by using the multiple-scale method. The influences of nonlinear stiffness coefficient, nonlinear damping coefficient, system damping coefficient and rolling force amplitude on vibration are further analyzed. The time-delay feedback controller is designed to eliminate the jump and hysteresis phenomenon of the roll system and numerical simulation results demonstrate the effectiveness of the controller. The analysis results provide some theoretical guidance for vibration suppression of roller system of corrugated rolling mill.
Prise en charge orthodontique des troubles respiratoires obstructifs du sommeil de l’enfant
Authors: Garrec Pascal , Legris Sylvie , Soyer Yves , Vi-Fane Brigitte , Jordan Laurence
Published: April 2020

Introduction :L’orthodontiste, par sa connaissance des phénomènes de croissance de la sphère orofaciale, joue un rôle de premier plan au sein de l’équipe pluridisciplinaire qui dépiste et traite les troubles respiratoires obstructifs du sommeil (TROS) de l’enfant.Discussion :En effet, depuis longtemps, il maîtrise les thérapeutiques comme l’expansion maxillaire rapide (EMR) chez les patients présentant une insuffisance maxillaire transversale, l’orthèse d’avancée mandibulaire (OAM) ou activateur chez les patients présentant, en phase de croissance, une rétrognathie mandibulaire et les thérapeutiques myofonctionnelles qui accompagnent les traitements des malocclusions associées à des dysfonctions de la sphère orale. Toutes les trois sont au coeur de la prise en charge des TROS de l’enfant.Conclusion :L’orthodontiste est donc un acteur clé de la chaine du traitement médical de ces enfants.
Traitement chirurgical des troubles respiratoires obstructifs du sommeil de l’adulte
Authors: Petelle Boris
Published: April 2020

Introduction : Le syndrome d’apnées obstructives du sommeil est
une maladie chronique caractérisée par la répétition d’un collapsus pharyngé
nocturne à l’origine d’une détérioration de la qualité de sommeil et d’une augmentation
des risques cardio-vasculaires. Sa prise en charge, classiquement par ventilation
en pression positive continue, est contraignante et n’est pas toujours bien
tolérée. L’alternative thérapeutique par orthèse est efficace dans 2/3 des cas avec
cependant des contraintes et des risques dentaires inhérents à un port au long
court. Afin de corriger cette pathologie, différentes solutions chirurgicales ont été
proposées. Matériels et méthodes : À travers une revue de la littérature, cet article
expose les différentes propositions chirurgicales développées pour la correction du
syndrome d’apnées obstructives du sommeil de l’adulte. Résultats : L’objectif est
le maintien de la perméabilité du pharynx pendant le sommeil en agissant soit sur
une réduction du volume des tissus mous, soit sur l’élargissement du squelette facial
ou, plus récemment, sur le tonus des muscles dilatateurs du pharynx. Parmi ces
solutions, le taux de succès le plus élevé rapporté est réalisé par une avancée maxillo-mandibulaire.
Ce projet nécessite une sélection rigoureuse des patients avec un
bilan et une prise en charge orthodontique adaptée. Discussion : La sélection des
patients, les avantages et inconvénients respectifs de ces solutions seront discutés.
Les indications sont rapportées dans le cadre des recommandations actuelles.
Troubles respiratoires obstructifs du sommeil de l’adulte : diagnostic, conséquences et comorbidités
Authors: Philippe Carole
Published: April 2020

Introduction :
Le syndrome d’apnées-hypopnées obstructives du
sommeil (SAHOS) est un collapsus des voies aérifères supérieures (VAS) conduisant
à une diminution (hypopnées) ou une interruption du débit aérien (apnées).
Depuis son identification il y a seulement une quarantaine d’années, les définitions
et les techniques diagnostiques ont évolué, les conséquences de ce syndrome
ont été largement étudiées, mais l’établir comme facteur de risque cardiovasculaire
(CV) indépendant s’est heurté à l’existence de nombreux facteurs confondants
ayant pignon sur rue, telles l’obésité, l’hypertension artérielle (HTA)… Matériels et méthodes : Le diagnostic paraclinique repose sur les résultats de
la poly(somno)graphie. Des recommandations sur les techniques de mesures et
le codage sont régulièrement éditées, évoluant parallèlement avec les progrès
technologiques, dans le but de standardiser et d’assurer la fiabilité du diagnostic.
Parallèlement, des études de larges cohortes ont été mises en place à partir
des années 1990, permettant un suivi transversal puis longitudinal de milliers
de patients. Enfin, les mécanismes physiopathologiques des conséquences du
SAHOS ont été explorés. Résultats : Il a été démontré que le SAHOS était
responsable d’un risque accidentel particulièrement élevé, imputable à la fragmentation
du sommeil induite par les événements respiratoires anormaux. Il a
pu être établi une relation statistique indépendante entre SAHOS et pathologies
CV, troubles métaboliques et plus récemment le cancer, expliquée majoritairement
par l’hypoxie intermittente.
Conclusions : Le SAHOS est une maladie
fréquente, dont le diagnostic repose sur des signes cliniques et la poly(somno)
graphie, établi aujourd’hui comme facteur de risque indépendant de morbi-mortalité
(accidentelle et CV).
Traitement non chirurgical des troubles respiratoires obstructifs du sommeil de l’adulte
Authors: Philippe Carole
Published: April 2020

Introduction : Le traitement du syndrome d’apnées-hypopnées
obstructives du sommeil (SAHOS) doit permettre la suppression des symptômes
et pouvoir également prévenir ses conséquences immédiates et à long
terme. Matériels et méthodes : L’évaluation de l’efficacité des traitements repose,
aujourd’hui, sur la normalisation de l’index d’apnées-hypopnées (IAH), de la
saturation en oxygène et sur la disparition de la fragmentation du sommeil.
Le suivi clinique et biologique des comorbidités doit être assuré. L’observance
au traitement, élément majeur de réussite, doit être surveillée. Résultats : La
ventilation par pression positive continue (PPC) est toujours le traitement le
plus efficace et le plus utilisé. Mais l’orthèse d’avancée mandibulaire (OAM)
est désormais recommandée en première intention dans les formes modérées en
l’absence de comorbidités cardiovasculaires (CV) sévères et reste une alternative
thérapeutique en cas de refus ou d’intolérance à la PPC. Une prise en charge
nutritionnelle en cas d’obésité et un programme d’activité physique doivent être
systématiquement proposés. Une réduction des troubles respiratoires nocturnes
peut également être obtenue grâce à un dispositif anti-décubitus dorsal en cas de
SAHOS positionnel, ou en limitant les mouvements de fluides. L’apport de la
thérapie myofonctionnelle est en cours d’évaluation. Très récemment, une étude a
testé l’efficacité d’un traitement pharmacologique sur la sévérité du SAHOS et la
réactivité du génioglosse, qui semble être prometteur. Conclusion : L’évaluation
de ces différents traitements et de leur combinaison devrait permettre d’évoluer
vers une prise en charge personnalisée adaptée à chaque patient.
Évaluation de l’impact sur les apprentissages des étudiants de leur participation comme acteurs pendant un examen clinique objectif structuré de sémiologie médicale
Authors: Barbosa Aleluia Iêda Maria , Nascimento Cardoso Karla Carolina
Published: April 2020

Contexte : Les examens cliniques objectifs structurés (ECOS), développés au cours des années 1970, sont une méthode pour évaluer les connaissances théoriques et pratiques, en s’appuyant sur la simulation d’un contexte clinique. Objectif : 1) analyser l’impact sur les apprentissages d’étudiants de leur participation en tant qu’acteurs à des ECOS destinés aux étudiants de deuxième année dans le cours de sémiologie médicale I ; 2) documenter la perception des étudiants acteurs sur leur processus d’apprentissage et leur développement personnel. Méthodes : Étude qualitative basée sur l’analyse de contenu des réponses à des questions ouvertes colligées en ligne auprès de 10 étudiants de première année de médecine. Résultats et conclusion : L’analyse des réponses révèle un impact positif sur l’apprentissage des étudiants-acteurs sur le plan cognitif et documente leur satisfaction de ce type d’évaluation.
Schwieriges Leben bei kosmetischen Komplikationen in der Praxis
Authors: Catalano Elena , Ammann-Rauch Dagmar
Published: April 2020

Hintergrund Bei zunehmender Anzahl an minimalinvasiven kosmetischen Prozeduren nehmen auch die Komplikationen zu, die in einer allgemeinophthalmologischen Praxis zu sehen sind.

Patienten und Methode Anhand von 4 Beispielen seit der ersten Begegnung an unserer Klinik vor 9 Jahren und heute möchten wir die Aufmerksamkeit für die Migration und Persistenz von Hyaluronfillern wecken.

Therapie und Verlauf Bei allen Fällen wirkte die Injektion von Hyaluronidase in die geschwollenen Lider, selbst viele Jahre nach Fillerinjektion und jahrelangem Ödem.

Schlussfolgerungen Jeder Ophthalmologe sollte diese Komplikation von Fillerinjektionen kennen, um den Patienten aufwendige, langwierige und teure Abklärungen zu ersparen und hingegen die wirksame, einfache und billige Therapie mit Hyaluronidase vorzuschlagen.
Schmerzhafte Bulbusluxation
Authors: Binder Anastasia Verena , Chaloupka Karla
Published: April 2020

Hintergrund Schmerzhafte Bulbusluxationen mit Inkarzerationen der Augenlider hinter dem Bulbus können spontan auftreten. Es ist wichtig, diesen raren und in der Literatur selten beschriebenen Prozess zu erkennen und die dazu führende Ätiologie zu diagnostizieren, um wiederholte Episoden mit möglichen schwerwiegenden Komplikationen wie Optikusneuropathien zu verhindern.

Anamnese und Symptome Wir stellen 2 Patienten vor (54- und 83-jährig, beide männlich) mit rezidivierender schmerzhafter Lidinkarzeration. Beim 54-jährigen Patienten ist diese im Rahmen eines bekannten Exophthalmus bei langjähriger endokriner Orbitopathie aufgetreten. Beim 83-jährigen Patienten lag ursächlich ein Floppy-Eyelid-Syndrom zugrunde.

Therapie und Ergebnisse In beiden Fällen erfolgte eine laterale Tarsorrhaphie, wodurch weitere Bulbusluxationen mit Inkarzeration der Lider und deren Folgen verhindert werden konnten.

Schlussfolgerung Bulbusluxationen durch passagere Inkarzeration der Augenlider treten selten auf und werden oft erst spät diagnostiziert, können jedoch mit schwerwiegenden Folgen einhergehen und müssen daher zeitnah erkannt und behandelt werden.
Hindbrain Herniation and Banana and Lemon Sign After Open Fetal Myelomeningocele Repair – When Do These Signs Disappear and is Shunting Predictable?
Authors: Vonzun Ladina , Winder Franziska Maria , Meuli Martin , Moehrlen Ueli , Mazzone Luca , Kraehenmann Franziska , Huesler Margaret , Zimmermann Roland , Ochsenbein-Kölble Nicole
Published: April 2020

Purpose The aim was to describe the sonographic follow-up of hindbrain herniation (HH), the banana and lemon sign after fetal myelomeningocele (fMMC) repair, and the time of disappearance of these signs after the intervention, and to investigate any predictive value for the necessity of shunting during the infant’s first year of life. Additionally, the sonographic evolution of the transcerebellar diameter (TCD) before and after fetal intervention was assessed.

Patients and Methods The first 50 patients that underwent fMMC repair at Zurich Center for Fetal Diagnosis and Therapy (www.swissfetus.ch) were included in this study. Sonographic scans performed weekly after fMMC repair focusing on HH and banana and lemon signs were analyzed and compared between the shunted and the non-shunted group. ROC curves were generated for the time intervals of resolution of the signs in order to show their predictive accuracy for the need for shunting until 1 year of age.

Results HH resolved in 48 fetuses (96 %) before delivery. The sonographic disappearance of HH within the first two weeks after fMMC repair was associated with a significantly lower incidence of shunt placement (OR 0.19; 95 % CI 0.4–0.9) during the first year of life (p = 0.03). All fetuses with persistent HH before delivery received a shunt. TCD growth was observed in all fetuses.

Conclusion The reversibility of HH within two weeks after fMMC repair is associated with an 80 % lower incidence of shunt placement during the infant’s first year of life. Moreover, it allows the cerebellum to grow and to normalize its configuration.
Die Therapie der chronischen metabolischen Azidose im diabetologischen Umfeld
Authors: Geiger Helmut , Kaiser Marcel , Rudolf Sarah , Büttner Stefan
Published: April 2020

Hintergrund: Die chronische metabolischen Azidose (cmA) ist eine häufige Komplikation bei chronischer Niereninsuffizienz, deren Behandlung bei niereninsuffizienten Patienten mit Diabetes mellitus die Insulinresistenz verbessern kann. Um die aktuelle Therapiesituation der cmA im diabetologischen Umfeld abzubilden und mehr über die Zusammenarbeit von Diabetologen und Nephrologen zu erfahren, wurden diabetologisch tätige Haus- und Fachärzte zur cmA befragt.

Methoden An 5863 Ärzten mit diabetologischer Zusatzqualifikation wurde postalisch ein Fragebogen versandt. Alle 97 erhaltenen Antwortbögen wurden deskriptiv ausgewertet.

Ergebnisse Die meisten Teilnehmer sind Internisten mit diabetologischer Zusatzqualifikation (46 %) und behandeln im Median 50 (10; 112) Patienten mit Typ-1-Diabetes bzw. 210 (100; 450) Patienten mit Typ-2-Diabetes pro Quartal. Eine cmA wurde von 12 % der Teilnehmer in den letzten 12 Monaten bei median 4 (2; 6) Patienten mit Typ-1-Diabetes und 10 (3; 30) Patienten mit Typ-2-Diabetes beobachtet. Die cmA wird überwiegend durch Bestimmung des Serum-Bikarbonats (27; 28 %) und des Base Excess (19; 20 %) diagnostiziert. 38 (39 %) der Teilnehmer erhalten regelmäßig von Nephrologen die Empfehlung zur Behandlung der cmA. Sie wird von knapp 1 Drittel als relevant (29 %) und gut umsetzbar (27 %) betrachtet. Zur Behandlung der cmA wird vor allem orales Bikarbonat empfohlen (Bikarbonat: 39 %, Zitrat: 5 %, sonst: keine Angabe). Maßnahmen, die die Mehrheit der Diabetologen in der Verantwortung der Nephrologen sehen, sind ergänzende Diagnostik (87; 90 %) einschließlich Blutgasanalyse (59 %) sowie die Behandlung der cmA (62 %) und renalen Anämie (53 %). 34 % der Diabetologen gaben an, bisher noch keine cmA-Fälle in der Praxis behandelt zu haben. Die meisten Diabetologen überlassen die Behandlung und Überwachung der cmA dem Nephrologen (38 %). Dabei wird die Zusammenarbeit mit den Nephrologen als zufriedenstellend (81 %) bewertet. 38 % der Befragten haben in der täglichen Praxis beobachtet, dass die Einstellung der cmA auch die Insulinresistenz positiv beeinflusst. Eine CME-Fortbildung in der Diabetologie speziell zur cmA würden 76 (78 %) begrüßen.

Diskussion Bei der Behandlung der cmA wird die Kooperation zwischen Diabetologen und Nephrologen generell gut bewertet, wobei die Diagnose, Behandlung und Überwachung einer cmA in der Verantwortung des Nephrologen gesehen werden. Da die Behandlung der cmA die Insulinresistenz verringern kann, sollte der Stellenwert der cmA-Therapie im diabetologischen Umfeld nicht unterschätzt werden. Um die cmA-Behandlung bei diabetischer Nephropathie zu optimieren, wären CME-Fortbildungen zur cmA geeignet. Zudem könnten Schulungen im Rahmen einer interdisziplinären Kooperation mit Diätberatern die Umsetzbarkeit diätetischer Interventionen zur Behandlung der cmA verbessern.
Geräteunterstütztes Krafttraining bei aortokoronar
bypassoperierten Patienten in der Anschlussheilbehandlung
Authors: Rauschenberg Sophie , Heinze Viktoria , Schwesig René , Bethge Steffi , Schlitt Axel
Published: April 2020

Einleitung Körperliche Aktivität gilt als wichtiger,
modifizierbarer Risikofaktor der Koronaren Herzkrankheit. In Ergänzung
zum aeroben Ausdauertraining wird moderates Krafttraining bei Patienten mit
Koronarer Herzkrankheit empfohlen. Unklar ist jedoch, ob und wann mit einem
Kraftausdauertraining nach aortokoronarer Bypassoperation begonnen werden kann,
um postoperativen Kraftdefiziten entgegenzuwirken.

Methodik Der Einschluss der aortokoronar bypassoperierten Patienten in
die prospektive Beobachtungsstudie zum Kraftausdauertraining erfolgte von Mai
2017 bis November 2018 in der Paracelsus-Harz-Klinik Bad Suderode.
Während der Anschlussheilbehandlung absolvierten die Patienten 3-mal pro
Woche eine Bewegungstherapie mit Kraftübungen, welche Dehn- und
Scherbewegungen am Sternum sowie eine Thoraxkompression vermieden. Drei Monate
nach dem Aufenthalt wurden die Patienten zu Wundheilungsstörungen,
anderen Komplikationen und erneuten Klinikaufenthalten befragt.

Ergebnisse 92% der Patienten waren männlich, das
Durchschnittsalter lag bei 61,7±12,3 Jahren und der mittlere BMI betrug
27,5±3,8 kg/m2. Die Patienten erreichten nach einem
Median von 16 (13/19) Tagen postoperativ die Anschlussheilbehandlung.
Während der stationären Rehabilitation traten bei 1,5%
der Patienten Wundheilungsstörungen auf, die konservativ behandelt
wurden. Im Follow-up gaben 8% Wundheilungsstörungen an, darunter
5 Patienten mit Narbeninfektionen und 3 weitere Patienten mit
verzögerten Heilprozessen. In 2 Fällen war das Sternum
betroffen. Weitere 8% gaben Schmerzen im Operationsgebiet an. Weiterhin
waren bei 7,8% der Patienten ein erneuter stationärer Aufenthalt
in einer Akutklinik nötig, bei einem Patienten im Rahmen einer
Wundheilungsstörung (Erysipel im Bereich der Saphenektomie-Narbe).

Schlussfolgerung Diese Beobachtungsstudie zeigt die kurz- und
mittelfristige Sicherheit eines selektiven Kraftausdauertrainings in der
stationären Rehabilitation, welches früh nach ACB-Operation
durchgeführt wird.
KNOWLEDGE REGARDING CARDIOVASCULAR RISK FACTORS AMONG PEOPLE IN SOUTH INDIA: A COMMUNITY BASED STUDY
Authors: Francis Joby , Jose Josmi , Sunny Joyse K. , S. Juvairiya U. , Varghese Sanil
Published: April 2020

Coronary Heart Disease (CHD) is the leading cause of death in the world. While it is well established as the foremost contributor to mortality in most developed countries, it is also a major and rapidly rising cause of death in many developing countries. To assess the existing knowledge of people regarding cardiovascular risk factors. This community based descriptive study was conducted to assess the knowledge regarding cardiovascular risk factors among community people. They were selected through Non probability convenient sampling and pre-validated semi-structured questionnaire related to various aspects of cardiovascular risk factors used. The data was analyzed using SPSS version 16 and the results expressed as proportion. A total of 100 community people surveyed, majority of the participants (98%) had average level of knowledge regarding cardiovascular risk factors. There was a significant association between knowledge and age (x2 =5.09, p<0.05). There was a significant association between knowledge and education (X2 =4.38, p<0.05). Majority of the participants (76%) did not have family history of heart diseases. The study reflects that majority of the participants (98%) had average level of knowledge regarding cardiovascular risk factors. Hence it is necessary to educate the people in community regarding cardio vascular risk factors.
PROCALCITONIN FOR IMPROVED ASSESSMENT AND AN ANSWER TO SEPSIS DILEMMA IN CRITICALLY ILL - A MYTH, A HYPE, OR A REALITY ?
Authors: Sharma Raghava , Vijayakumar Maniyar
Published: April 2020

Background and objectives: “Sepsis is a major cause for mortality in critically ill patients all over the world. The number of patients presenting with sepsis, septic shock is gradually increasing in daily clinical practice. Mortality in sepsis is mainly due to a delay in diagnosis and initiation of specific therapy(antibiotics).This is in turn mainly attributed to the difficulty in differentiating infectious trigger(sepsis) from non infectious triggers as both present with similar clinical features. Lack of specific marker adds to this dilemma of differentiating infectious and non infectious factors in critically ill patients.

Recently there are some reports from European countries on role of Procalcitonin (PCT) in critically ill patients. Draw backs of these studies are galore mainly due to the difficulties in interpretation of results, as varying definitions for sepsis are used. But also there is paucity of data on Procalcitonin from Indian sub continent. Hence in the present single centre prospective observational study conducted at tertiary care medical college hospital , A total of 50 adult patients with sepsis fulfilling ACCP/SCCM guidelines were included, out of which 23 were in SIRS/Sepsis, 14 in severe sepsis and 13 in septic shock. Procalcitonin was evaluated in the first 24 hours after admission and before initiation of any antibiotic therapy. The role of procalcitonin was analyzed in relation to confirming sepsis, assessing the severity of sepsis and assessing the prognosis(possible out come) of sepsis. Combined role of procalcitonin with other indicators especially ESR, SOFA Score, Blood/relevant material culture was explored.

Results: Our study confirmed the importance of procalcitonin in critically ill patients particularly in improving the predictive power while solving the sepsis dilemma.

Conclusions: From our study, we conclude that Procalcitonin is not a myth nor a hype but it is a hard reality and is an answer to sepsis dilemma. It is therefore preferable to add Procalcitonin into the standard workup of critically ill patients with suspected sepsis in every day clinical practice.
IMPACT OF A NOVEL METHOD OF TEACHING ANATOMY OF THE MALE PERINEUM ON THE UNDERGRADUATE MEDICAL STUDENTS
Authors: Mishra Snigdha , B. Satheesha Nayak , George Bincy M.
Published: April 2020

It is indeed a challenge to teach the cadaveric anatomy of the perineum to the undergraduate medical students. The anatomy teacher often fails to make the student understand the exact arrangement and attachments of the fasciae in the perineum in spite of his/her best attempts in the dissection hall and lecture classes. We prepared a video to demonstrate the arrangements of fasciae in the male perineum. The video had a combination of clips of cadaveric dissection, diagrams drawn on a blackboard and the demonstration of the arrangement of fasciae using a simple cloth model. The video was shown to students after they had the routine dissection and lecture classes about the perineum. There was a significant difference between the pre and post test scores. The opinion survey also indicated that the video was very effective.
UNUSUAL PRESENTATION OF SOLITARY BONE CYST - A CASE REPORT
Authors: Ajila Vidya , R. Gopakumar , Hegde Shruthi , Babu Subhas , K. Harini
Published: April 2020

Solitary bone cyst, also known as traumatic bone cyst or idiopathic bone cyst, is a bony cavity with no epithelial lining and no infection, containing fluid and small amounts of tissue. Clinically these lesions are usually asymptomatic and detected accidentally on routine radiographic examination. Normally, they are empty cavities sometimes having a thin lining of connective tissue without epithelium. They may contain serosanguinous fluid, clots, erythrocytes, fibrin and giant cells. In this report, we present a case of solitary bone cyst in the anterior mandible which was associated with pain.
VARIOUS ANOMALIES OF THE THORAX
Authors: Ankolekar Vrinda Hari , D'Souza Antony Sylvan , Quadros Lydia S. , H. Mamatha , S. Suhani , Bangera Hemalatha S. ,   Radhakrishnan
Published: April 2020

During routine dissection of the thoracic region of a 55-year old male cadaver, in the department of Anatomy, Kasturba Medical
College, Manipal, various anomalies were noticed in the thoracic region.

a) The arch of aorta gave rise to four branches, the right common carotid artery, left common carotid artery, left subclavian artery and a right subclavian artery. The origin of the right subclavian artery was to the left of the midline and in order to reach the right arm, the artery coursed behind both the trachea and oesophagus.

b) Cervical rib was present on both the sides.

c) Thoracic duct coursed on the same side without crossing to the left at the T5 vertebral level.

d)Hemiazygos vein was underdeveloped.
PROSTHODONTIC MANAGEMENT OF COMPROMISED RIDGES AND SITUATIONS
Authors: D. Krishna Prasad , Mehra Divya , D. Anupama Prasad
Published: April 2020

Prosthodontic rehabilitation of a patient with compromised edentulous ridges in a conventional manner is a difficult task. Modifications in the treatment procedures should be considered to fulfil the patient's functional and esthetic desires. This article reviews the various compromised situations commonly encountered in a routine clinical practice and the possible management of each of them.
Assessment of Oropharyngeal Widths in Individuals with Different Facial Skeletal Patterns
Authors: Gupta Swathi , Subrahmanya Ravi M.
Published: April 2020

Background and objectives: The relationship between airway patency and craniofacial development is highly debated and controversial subject. Hence this was conducted with the aims and objectives of comparing and correlating the upper & lower Oropharyngeal widths in individuals with horizontal growth pattern with that of individuals having vertical growth pattern.

Methodology: 60 subjects (30 males & 30 females) in the age group of 16 to 20 years were selected as per inclusion criteria. They were divided into two groups (Group I and Group II) according to their skeletal pattern in vertical plane based on Jarabak' sratio and Y axis. . Pharyngeal width measurement was done based on McNamara analysis The data obtained was statistically evaluated using Mann-Whitney U test (Z test).

Results: Significant correlation was found between facial skeletal patterns and upper and lower Oropharyngeal widths. The subjects with vertical skeletal pattern were found to have significantly narrower upper airways and broader lower airways than those with horizontal skeletal pattern.

Interpretation and conclusion: The study supports the existence of a relationship between facial skeletal patterns and upper and lower oropharyngeal widths.
A SURVEY TO ASSESS PATIENT SATISFACTION AFTER RECEIVING COMPLETE DENTURE PROSTHESES IN A.B. SHETTY MEMORIAL INSTITUTE OF DENTAL SCIENCES
Authors: Bhat Vinaya S. , D. Krishna Prasad , Malli Prakyath
Published: April 2020

Conventional complete denture therapy is the most extensively used form of treatment for replacement of missing dentition. Patient satisfaction plays a major role in determining the success during treatment procedures. It helps in assessment of certain psychological traits and the impact of complete denture prostheses on daily living. This study was done to evaluate the relationship between patient satisfaction and the newly constructed denture prostheses, as it would indicate the degree of success of the treatment given.
CYTOLOGICAL EXPERIENCE OF PAEDIATRIC RETROPERITONEAL GANGLIONEUROMA- A RARE CASE REPORT
Authors: Permi Harish S. , Rai Sandeep , Shetty Padma , Y. Sunil Kumar , S. Kiran H. ,   Raghushankar
Published: April 2020

Ganglioneuroma is a benign tumor that originates from primordial neural crest cells which migrate from the mantle layer of the developing spinal cord to the sympathetic ganglia, adrenal medulla, and other sites. The most affected anatomical sites are the posterior mediastinum, retroperitoneum, adrenal gland, head and neck. It occurs most commonly in children over 10 years of age and consists of ganglion and Schwann cells. We report a case of 9 – year- old male child who presented with mass per abdomen in the right hypochondrium. Fine needle aspiration cytology showed mature ganglion cells and cluster of Schwann cells suggestive of Ganglioneuroma. Cytology diagnosis was confirmed by histopathological examination of tru-cut biopsy and subsequently excised specimen. On regular follow he is doing fine without any symptoms.
A RARE CAUSE OF URETHRAL OBSTRUCTION IN AN INFANT - CONGENITAL POSTERIOR URETHRAL POLYP
Authors: Rai Sandeep B. , Shankar Raghu
Published: April 2020

Urethral polyp is a rare finding in young children. These are congenital fibroepithelial benign polyp in the prostatic urethra. They present with acute or intermittent urinary obstruction, hematuria or voiding dysfunction. Their diagnosis requires a high index of suspicion because of variability in presentation. Diagnosis can be made by ultrasonography or micturating cystourethrogram, however cystourethroscopy is confirmatory. Transurethral resection is possible in almost all the cases and recurrence is almost unknown. We report a case of this rare lesion in a male infant with a severe phimosis.
Relevance of the Entropy Factor in Stereoselectivity Control of Asymmetric Photoreactions
Authors: Mori Tadashi
Published: April 2020

Entropy as well as enthalpy factors play substantial roles in various chemical phenomena such as equilibrium and reactions. However, the entropy factors are frequently underestimated in most instances, particularly in synthetic chemistry. In reality, the entropy factor can be in competition with the enthalpy factor or can even be decisive in determining the overall free or activation energy change upon molecular interaction and chemical transformation, particularly where weak interactions in ground and/or excited states are significant. In this account, we overview the importance of the entropy factor in various chemical phenomena in both thermodynamics and kinetics and in the ground and excited states. It is immediately apparent that many diastereo- and enantioselective photoreactions are entropy-controlled. Recent advances on the entropy-control concept in asymmetric photoreactions are further discussed. Understanding the entropy-control concept will pave the way to improve, fine-tune, and even invert the chemo- and stereoselectivity of relevant chemical phenomena.

1 Introduction

2 Role of Entropy in Supramolecular Interactions

3 Selected Examples of Entropy-Driven Thermal Reactions

4 Classical Examples of Entropy Control in Photoreactions

5 Entropy-Driven Asymmetric Photoreactions

6 Advances in Entropy Control

7 Perspective
Local References for Ultrasound-Estimated Fetal Weight Based on 2,211 Singleton Pregnancies in the City of Curitiba, South of Brazil
Authors: Kato Daniel Massamatsu Pianovski , Lorusso Liziane , Costa Natália Roberta Andrade Dalla , Ulyssea Camila Rotter Queiroz , Lizana Gabrielle Navarro , Lenzi Luana , Bruns Rafael Frederico , Pinhat Elisa Chicareli , Araujo Júnior Edward
Published: April 2020

Objective To develop reference curves of estimated fetal weight for a local population in Curitiba, South of Brazil, and compare them with the curves established for other populations.

Methods An observational, cross-sectional, retrospective study was conducted. A reference model for estimated fetal weight was developed using a local sample of 2,211 singleton pregnancies with low risk of growth disorders and well-defined gestational age. This model was compared graphically with the Hadlock and Intergrowth 21st curves.

Results Reference curves for estimated fetal weight were developed for a local population. The coefficient of determination was R2 = 99.11%, indicating that 99.11% of the fetal weight variations were explained by the model. Compared with Hadlock curves, the 50th, 90th, and 97th percentiles in this model were lower, whereas the 10th percentile nearly overlapped, and the 3rd percentile was slightly higher in the proposed model. The percentiles were higher in the proposed model compared with the Intergrowth 21st curves, particularly for the 3rd, 10th, and 50th percentiles.

Conclusion We provide a local reference curve for estimated fetal weight. The proposed model was different from other models, and these differences might be due to the use of different populations for model construction.
Vortex guidance and transport in channeled pinning arrays
Authors: Reichhardt C. , Reichhardt C. J. O.
Published: April 2020

We numerically examine vortices interacting with pinning arrays where a portion of the pinning sites have been removed in order to create coexisting regions of strong and weak pinning. The region without pinning sites acts as an easy-flow channel. For driving in different directions with respect to the channel, we observe distinct types of vortex flow. When the drive is parallel to the channel, the flow first occurs in the pin free region followed by a secondary depinning transition in the pinned region. At high vortex densities there is also an intermediate plastic flow phase due to the coupling between the weak and strong pinning regions. For driving applied perpendicular to the channel, we observe a jammed phase in which vortices accumulate on the boundary of the pinned region due to the vortex-vortex repulsion, while at higher drives the vortices begin to flow through the pinning array. For driving at an angle to the channel, depending on the filling we observe a drive-induced reentrant pinning effect as well as negative differential mobility which occurs when vortices move from the unpinned to the pinned portion of the sample.
Misorientation angle dependence of the critical current in HTS bicrystals with low-angle [001]-tilt grain boundaries
Authors: Kasatkin A. L. , Tsvetkovskii V. P.
Published: April 2020

Dependence of the critical current on the misorientation angle in high-temperature superconductor (HTS) [001]-tilt bicrystal is theoretically examined. It’s argued that in the case of relatively small values of the bicrystal misorientation angle θ (θ ≤ 10–15°) the critical current as well as the resistive state emergence are determined by depinning of Abrikosov vortices, which are locked by c-oriented edge dislocations which form the low-angle [001]-tilt grain boundary and are aligned in a linear row along it. Dependence of the depinning critical current on the misorientation angle of bicrystal is calculated for this case and it reveals a good agreement with experimental data obtained on HTS bicrystals with low-angle [001]-tilt grain boundaries.
Flux flow instability in type II superconducting strips: Spatially uniform versus nonuniform transition
Authors: Vodolazov D. Yu.
Published: April 2020

We discuss two possible mechanisms of the flux flow instability (FFI) in type II superconducting strips. While the nature of nonequilibrium effects leading to this instability is widely accepted (Joule heating and finite relaxation time of the superconducting order parameter) still there is a question how FFI develops in space. According to one scenario instability occurs simultaneously in the whole sample and superconductor jumps to the normal or resistive state with no change in the structure of moving vortex array. Another scenario predicts appearance of the vortex rivers at the instability point and jump of the superconductor to the normal or the resistive state but with strongly modified structure of the moving vorticies.
Vortex generation in a superfluid gas of dipolar chains in crossed electric and magnetic fields
Authors: Fil D. V. , Shevchenko S. I.
Published: April 2020

Crossed electric and magnetic fields influence dipolar neutral particles in the same way as the magnetic field influences charged particles. The effect of crossed fields is proportional to the dipole moment of the particle (inherent or induced). We show that this effect is quite spectacular in a multilayer system of polar molecules. In this system molecules may bind in chains. At low temperature the gas of chains becomes the superfluid one. The crossed fields then induce vortices in the superfluid gas of chains. The density of vortices is proportional to the number of particles in the chain. The effect can be used for monitoring the formation and destruction of chains in multilayer dipolar gases.
Levitated magnetic dipole system can simultaneously trap positrons and electrons
Authors: Bandari Anashe
Published: April 2020

Inspired by planetary magnetospheres, researchers studied the feasibility of using a levitated trap to confine particles.
An evolving fitness network model shows promise for mapping COVID-19
Authors: Mandel Savannah
Published: April 2020

Researchers present a method to model evolving community networks which may have applications in mapping social interaction in real and online communities.
Linguistic description and language philosophy in Wilhelm von
Humboldt’s North American grammars
Authors: Verlato Micaela
Published: April 2020

The focus of this paper is on three grammars of native
North American languages (Massachusett, Mahican, Onondaga) that
Wilhelm von Humboldt wrote in 1822–1823. The first part of the paper
describes these grammars and situates them in the context of early
comparative Americanist linguistics that was emerging in Germany and
North America. The second part presents an example of Humboldt’s
descriptive work drawn from his analysis of the Massachusett verb
and shows how his attempt at understanding the Algonquian system of
expressing grammatical relations is linked to the evolution of his
language philosophy.
Greek grammatical learning papyri
Authors: Swiggers Pierre , Wouters Alfons , Van Elst Valerie
Published: April 2020

This contribution offers an attempt at defining the genre
of grammatical school papyri, on the basis of a corpus of some 65
relevant papyri, roughly ranging from the 1st to the 8th century AD.
After a brief overview of the heuristic and methodological state of
the art, we offer a content-based typology of the grammatical
papyri, as forming part of the ancient schooling system.
Subsequently we discuss the function and the general characteristics
of the various text types, before dealing in greater detail with the
papyri containing a technê grammatikê.
Intercultural interaction management
Authors: Aikawa Hiroko
Published: April 2020

Recent Japanese government policy and public rhetoric focus on fostering global human resources with strong English skills and a global mindset to succeed in the globalized economy. This study investigates how Japanese and non-Japanese professionals try to deal with linguistic and non-linguistic problems when they interact with their business partners and colleagues in English. The study shows how the identification of the source of these problems can affect adjustment design. The findings reveal that although various deviations were noted, the participants were rarely able to identify the source of the problems. This inadequate identification of the source of the problem at the interactional level was seen to lead to ineffective adjustment design and implementation, including at the institutional level.
Transcriptome alterations in HepG2 cells induced by shRNA knockdown and overexpression of TMEM2 gene
Authors: Jia Xiuhua , Mo Zhishuo , Zhao Qiyi , Bao Tiancheng , Xu Wexiong , Gao Zhiliang , Peng Liang , Zhu Xiang
Published: April 2020

Transmembrane 2 (TMEM2) gene inhibits chronic hepatitis-B virus (HBV) infection, while the underlying molecular mechanisms remain unknown. Transcriptome alterations in HepG2 cells following TMEM2 overexpression or silencing by shRNA were analyzed by next-generation sequencing. Both overexpression and knockdown of the TMEM2 gene caused wide-spread changes in gene expression in HepG2 cells. Differentially expressed genes caused by altered TMEM2 gene expression were associated with multiple biological processes linked with viral infection and various signaling pathways. KEGG analysis revealed that many of the differentially expressed genes were enriched in the PI3K/AKT signaling pathway. Moreover, we show that genes related to the PI3K/AKT signaling pathway, such as SYK, FLT4, AKT3, FLT1, and IL6, are biological targets regulated by TMEM2 in HepG2 cells. This is the first transcriptome-wide study in which TMEM2-regulated genes in HepG2 cells have been screened. Our findings elucidate the molecular events associated with TMEM2-mediated hepatocyte pathogenesis in chronic HBV infection.