bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of Reserves for Improving the Efficiency of Using Rolling Stock of a Motor Transport Enterprise
Authors: Khavruk V. O
Published: December 2022

Purpose. The work is aimed to analyze the components of the target function of reducing costs for the operation and maintenance of motor vehicles (buses) and determine the optimal periodicity of planned repairs. Methodology. The research was carried out using general scientific methods: analysis and synthesis, abstraction and concretization, induction and deduction, system analysis. Findings. In order to estimate reserves for improving the efficiency of rolling stock, the target function of minimizing costs (losses) during the operation of motor vehicles using the example of buses is given, which includes two aggregated component costs for planned activities after maintenance of motor vehicles and resources used to eliminate the consequences of unplanned repairs, including losses caused by them. Exponential dependencies of the number of unplanned repairs per calendar year of operation of motor vehicles obtained as a result of processing an array of statistical data on the enterprise are presented. It was found that one of the ways to improve the efficiency of the rolling stock of the motor vehicle enterprise is to reduce downtime due to current unplanned repairs. For this purpose, it is proposed to carry out planned repairs of each moving unit of motor vehicles. The graphical dependence of the number of unscheduled repairs on the amount of bus mileage between repairs is shown for a specific motor vehicle enterprise. Calculations of the components of the target function of increasing the use efficiency of buses were performed, and the optimal inter-repair mileage for carrying out planned repairs during the calendar year was determined graphically. The economic component of increasing the efficiency of use of the rolling stock of the automobile enterprise is substantiated – the lack of income from unfulfilled transport work, which is characterized by the average load of motor vehicles. Using the example of buses, it was found that the average load is directly proportional to the number of transported passengers and inversely proportional to the mileage along the route. Originality. All components of the target function of minimizing the total costs of planned activities after technical maintenance and resources of unplanned repairs, including losses (damages) from downtime, are thoroughly considered. Practical value. The results of the performed research can be used by motor transport companies to determine the optimal intervals between repairs. Carrying out planned repairs of each motor vehicle will make it possible to reduce losses from idle time and increase the use efficiency of rolling stock as a whole.
Experimental Research of the Energy Efficiency of Accelerated Thermal Tests of Traction Electric Machines
Authors: Vasyliev V. Y , Afanasov A. M , Hulivets O. M. , Popudniak Y. Y
Published: December 2022

Purpose. Heating tests of traction electric machines are the most energy-intensive tests. Taking into account the need to choose a rational variant of the mutual load scheme in order to reduce the consumption of electrical energy during the tests, a study of the amount of total useful energy of the power sources of the stand at hourly and starting current was carried out. Methodology. Experimental studies were carried out on a mutual load stand. Rotating machines were used as power sources (voltage booster and linear generator). The voltage and field attenuation coefficient of the traction motors during the tests were kept nominal. The condition of the equality of the final temperature excesses of the tested traction motors for both test modes was the achievement of the same total circuit resistance. For analysis of test results, methods of theoretical research and analytical calculation of electric circuits, theoretical foundations of electrical engineering, mathematical modeling of electrical and energy processes were used. Findings. The conducted set of tests on heating the traction motors of electric rolling stock practically showed that the consumption of electrical energy at the starting current is 36% lower compared to the hourly load mode. Tests on the mutual load stand confirmed the practical possibility of accelerated tests of traction electric motors. Originality. It has been practically proven that the use of the heating test mode with the starting current ensures an increase in the energy efficiency of the tests and a corresponding reduction in the total electricity consumption for acceptance tests. Further development of practical research is planned for the purpose of determining energy saving reserves during post-repair tests of traction electric motors of highway, quarry and suburban transport. Practical value. The results of practical tests can become the basis for modernization of mutual load stands of locomotive repair enterprises for thermal tests of traction motors of direct and pulsating current. The conducted tests allow us to create recommendations for the design of rational schemes of test benches with increased energy efficiency of the system of mutual loading of traction electric machines, which differ by accounting the efficiency of sources and power converters.
Difference and identity – in search for areas of axiological identification
Authors: Karkowska Magda
Published: December 2022

The main idea that accompanies this article is an attempt to organize the relationship between the difference as a result of cultural changes and the identity of the individual understood as a sense of continuity, permanence and integrity, as well as to reflect on the nature and scope of differences what appear in Polish society in the second decade of the 21st century. Therefore, I ask some questions about the main spheres of them, but also about the consequences of analyzed differences for our identity and how do they influence its construction? Source of what kind of experiences are they ? How do differences affect our social participation, self-esteem or decisions made in important spheres of life? Finally, the question of differences is also, and perhaps above all, a question about values and where, in the situation of experiencing and realizing the difference to look for areas of understanding and axiological identification? What family experiences and elements of intergenerational transmission then should be applied? Questions mentioned above are only the frame for considerations undertaken in this article.
What could the phenomenal identity be? Considerations on the basis of retrospective description of my own research and analyses of the concepts of philosophy
Authors: Muszyńska Małgorzata
Published: December 2022

The text is a re-examination of the reflections that result from theoretical analyses of my earlier research. They concerned metaphorical thinking, seeing and constructing visual analogies and the critical thinking of an allegorist using irony. My experience in education research prompted me to reflect on the phenomenal identity of the participants of the alternative proposed in my studies. The question is whether the characterization of the phenomenal identity can be fulfilled in associated contexts drawn from the concepts of philosophy. “The epiphany of the face” by E. Lévinas and M. Merleau-Ponty’s “the phenomenal field” are concepts that, in my opinion, can be used to explain the meaning of acts of action in the “educational opportunities” of the person gaining phenomenal identity (R.M. Łukaszewicz; M. Muszyńska).
Creative competences in the perspective of positive resources
Authors: Wróblewska Halina Monika
Published: December 2022

The subject of the study are creative competences presented as the potential of subjective resources. It presents the issues of research questions, empirical verifications, and includes references and inspirations. The adopted perspective of development resources determines a positive model of human development. It fits in with the postulate of developing positive education, aimed at supporting human creative resources, building educational programs in a climate of pro-creativity and pro-capacity. The adopted positive resource perspective is part of the trend of positive pedagogy (positive development).
Coronavirus Generation as a legacy from the COVID-19 disease pandemic(?) – an attempt to characterize
Authors: Myszka-Strychalska Lucyna
Published: December 2022

The article attempts to answer the question: “How has the experience of the SARS-CoV-2 virus pandemic and the COVID-19 disease it causes contributed to shaping the Coronavirus Generation among adolescents?” Based on the review of the results of research on academic youth and young adults, which were carried out during the pandemic period, published in selected scientific articles, reports and internet sources, a description of changes taking place in various areas of their lives (such as: interpersonal relations, internal life, development personal, professional career, education, health, housing and material situation) and outlined the expected features that could define the representatives of the new generation. Although the collected data do not justify drawing an unambiguous conclusion about the existence of the Coronavirus Generation (it will be possible to do so in the longer term), they indicate that the time of the pandemic contributed to significant modifications in many spheres of the existence of young people, which will probably not remain insignificant for their future.
What about this change? – opinions of teachers of early school education about school reading
Authors: Józefowicz Anna
Published: December 2022

Introduction: The text presents the results of a diagnostic survey conducted in the first quarter of 2022 among teachers of early childhood education. It was conducted in order to collect teachers' opinions on the change made in the reading list, effective from 01/09/2021. The text is set in an interpretative paradigm, in the spirit of critical and creative education focused on the subjectivity of participants in the educational process, that perceives teaching as a creative process. I base the theoretical assumptions on such key categories as change in education (Klus-Stańska), open and closed school culture changes (Zamorska, Krzychała), invisible change (Bober), apparent change (Dudzikowa), I draw attention to the importance of teachers' participatory participation in the change as well as emphasizing the reading from the perspective of the text of culture, the medium and the linguistic transmitter of the world image. Research Aim: Interviews with teachers present the position of early school education teachers towards the change made, their orientation in the latest reading offer addressed to the child, their beliefs, needs and possibilities of its implementation. Method: The data collection method used was a diagnostic survey. The technique used was a qualitative in-depth interview, partially structured, focused on the problem of the perceived change in reading and the organization of work with reading. The study included 17 teachers of early childhood education from 17 primary schools in the Białystok town. Conclusion: The results of the survey are aimed at drawing attention to the problem of shaping educational policy in the above-mentioned scope.
Francophonie : enjeux d’une planification linguistique en Afrique de l’Est
Authors: DELABIE AnaÏs
Published: December 2022

Cet article propose d’examiner la situation de la F(f)rancophonie en Tanzanie et les enjeux didactiques et éthiques que la langue représente pour la Région des Grands Lacs et de l’Afrique de l’Est. La situation du français en tant que langue étrangère est étudiée d’un point de vue interne/externe , en portant l’attention sur les politiques linguistiques françaises, tanzaniennes et régionales. Celles-ci reposant sur la production de discours institutionnels, des tournants discursifs diplomatiques sont relevés afin de mettre en relief les modifications de la nature et des objectifs de la Francophonie. Il en résulte une mise en avant de certains acteurs et une valorisation de pratiques didactiques et pédagogiques en cohérence avec les standards français et européens, au détriment des initiatives portées par la population africaine francophone présente dans les rangs du professorat. Par l’analyse de données relevées en Tanzanie entre 2016 et 2018, la création discursive et l’incarnation de deux F(f)rancophonies sont examinées. Les pistes pour penser l’identité est-africaine dans la F(f)rancophonie sont entravées par l’auto-odi (Kremnitz, 1980), (Garabato, Colonna, 2016), et par les difficultés des institutions à intégrer le changement.
Langues, environnement lettré et développement durable
Authors: SILUÉ Sassongo Jacques , DIOMANDE-KEITA Jacqueline Siamba Gabrielle
Published: December 2022

En dépit d’une aide extérieure continue, l’Afrique n’arrive toujours pas à trouver le chemin du développement. Le développement ayant fondement anthropologique, sans doute, faut-il mettre l’Homme au centre du processus en optimisant ses capacités endogènes à partir de l’écriture dans sa propre langue. L’objectif de la présente étude est de montrer que l’on peut engager un développement durable si l’on travaille à asseoir un environnement lettré de qualité à partir d’une promotion de la culture du mot écrit. Un constat indiscutable est que la quasi-totalité des nations reconnues comme développées sont mues par la culture de l’écriture de leurs langues, alors que dans celles qui peinent à se développer, comme les nations subsahariennes, la culture de l’écrit reste marginale. Pour y promouvoir un environnement lettré, il faut se tourner vers les langues qui devront être instrumentalisées pour l’éducation, en les dotant de systèmes d’écriture. Il ne suffira pas d’apprendre aux individus à lire passivement, c’est-à-dire, à décoder simplement des textes déjà écrits; il faudra surtout les former à la production de l’information écrite à des fins scientifiques et techniques réelles et que la pratique du mot écrit soit étendue à forte proportion des membres de la société.
Comment dit-on « chemin de traverse » en dioula ?
Authors: BOUYAIN Sarah
Published: December 2022

Métisse franco-burkinabé, j’établis des liens entre mon apprentissage de la langue dioula, la langue parlée par mon père, mais aussi une langue véhiculaire d’Afrique de L’Ouest et la genèse de mon long métrage de fiction, « Notre étrangère », sorti sur les écrans français en 2011 et primé cette année-là au FESPACO (Festival PAnafricain du Cinéma de Ouagadougou).
Convenience of frustration purpose in Peru
Authors: Che León Chueng José Luis , Chávez Gutiérrez Sara Ysabel del Carmen , Rojas Luján Víctor William
Published: December 2022

When after the conclusion of a contract, events occur that cause one or both parties to lose interest and usefulness in the benefits of the same, it is what is known in doctrine as the frustration of the end of the contract. The objective of this work was to establish the convenience of the frustration of the end of the contract, in Peru. It was a qualitative, basic and explanatory research, since its main purpose was to discover and verify new theories in law that demonstrate the causal relationships of the investigated categories. The interview technique was used. Then, the collected data was analyzed and interpreted, according to the problem and the objective. It was concluded that according to the evaluation carried out in the theoretical framework of the work and the interview carried out with the specialists in civil patrimonial law, it is convenient to frustration purpose for Peru, in order to avoid injustices between the contracting parties. And for this, it would be convenient to implement this legal figure at the normative level, through the addition of an article in the civil code.
Strategies Pack Program to improve the English learning of students in the VII cycle of a public school in the La Esperanza district
Authors: Yllia Castillo Gregoria Judith
Published: December 2022

Quantitative research whose purpose was to determine to what extent the Strategies Pack Program improves the level of English learning of the students of the César Vallejo public school. The sample was obtained using non probabilistic discretionary sampling. The design was quasi experimental with two groups and pre-post test application with techniques and instruments: observation: with observations guides; the survey with pre and pos test and a dichotomous structured satisfaction survey. A homogeneity test was applied to the data. The results of the post test showed that 79% of the participants went from the level in process to the expected level. The chi square test X2 = 133.87 and the value p=0.0000<0.05, it shows that the Strategies Pack Program is highly significantly improved the student´s English learning level, verifying the proposed hypothesis. In the guides a sustained increase is observed: In august 13.27; September 14.26; October 16.02 and November 16.80. The survey showed that 98.6% were satisfied with the program. By triangulating the results it is affirmed that the Program improved in a highly significant and sustained way the level of English learning of the participants.
The educational workshop as a strategy to promote environmental awareness in high school students
Authors: Buñon Sangay Percy Rafael , Romero Castro Kervin Alejandro , Orbegoso Ayala Vicente Heriberto
Published: December 2022

A documentary research of reliable and pertinent information was carried out regarding the conceptual realities of the study: "The educational workshop and environmental awareness in high school students". The objective was to describe the theoretical bases and find the link between the educational workshop and environmental awareness, with the purpose of proposing the theoretical bases for the subsequent implementation of an educational workshop that allows to transform the knowledge, values and practices of young people to change the environmental reality. In the documentary review, different repositories, magazines, web portals, digital bibliography were investigated to extract those aspects that would be useful to support the work and it was synthesized in tables and figures. The theoretical review managed to select the theoretical foundations of both the educational workshop and environmental awareness and also the conceptual link between both theoretical realities.
Changes in the PMBOK Guide of the Project Management Institute, its Certification and application in Project Management: A systematic literature review
Authors: Ruiz Jaramillo Raimer Lartsimin , Marquez Yauri Heyner Yuliano
Published: December 2022

This work presents a review of information, in which the PMBOK Guide is described and defined, as well as the Project Management Institute (PMI), which is the organization that promotes it. Similarly, it describes how this guide has evolved over time from its fifth to seventh editions. The world-class certifications provided by this organization are also rescued, being the PMP®, Professional in Project Management, the most recognized. Likewise, it mentions the way in which this guide and its certification is applied within project management. This review has the purpose of giving people, organizations, companies and all those involved in project management, a consultation and reference tool that they can take into account for each of the projects in which they have been performing.
RSV whole genome sequencing using ONT v1
Authors: Komissarova Kseniia
Published: December 2022

Respiratory Syncytial Virus (RSV) is a leading cause of hospitalization due to acute lower respiratory infection in infants and young children. Monoclonal antibodies palivizumab is available option for treating RSV limited to select populations in high-resource settings. There is no vaccine to prevent RSV to the moment. Fortunately, several vaccine candidates are now in the human testing phase targeting young children, older adults and pregnant women, and an effective safe vaccine is likely to be available in the near future. For vaccine and therapy development RSV surveillance is essential. Using whole-genome sequencing data helps ensure the vaccine has the most up-to-date coverage and more-effective global reach. Through genomic surveillance we can track the spread of variants, monitor changes to the genetic code of the virus. Finally, this data is used to better understand how virus might impact public health. Here we provide the protocol for genome sequencing of RSV A using Oxford Nanopore Technology platform. The four overlapping genome fragments together comprise of the full RSV genome encompassing all viral genes, yet lacking the far 3′ and 5′ genome termini.
Editorial: Inclusive Media Literacy Education for Diverse Societies
Authors: Bozdağ Çiğdem , Neag Annamária , Leurs Koen
Published: December 2022

This editorial introduces the thematic issue titled Inclusive Media Literacy Education for Diverse Societies. We start by introducing our aims for developing a more open and inviting approach to media education. We argue for a media education that acknowledges a variety of voices, and that provides skills and recognition for everyone, irrespective of their social class, status, gender identification, sexuality, race, ability, and other variables. The articles in this issue address the role of media literacy education in relation to questions of in- and exclusion, social justice, voice, and listening. The issue covers a variety of critical, non-Western perspectives needed to challenge dominant regimes of representation. The editorial is enriched by the artist Neetje’s illustrations of the workshop that preceded the publication of this thematic issue.
A experiência de viajar para re(conectar): uma análise das pesquisas sobre o turismo de bem-estar e da sua promoção através do Instagram
Authors: Paes-Cesário Marilia Ferreira
Published: December 2022

O comportamento do consumidor mudou bastante e com a pandemia de COVID-19 e essas alterações tornaram-se mais significativas. Acredita-se que, mesmo com a melhoria dos números de casos da doença, pessoas ainda continuarão buscando formas seguras de viajar e espaços onde possam ir para se reconectar e se reabilitar do estresse cotidiano. Um dos segmentos turísticos que têm sido capaz de atender a essas solicitações é o turismo de saúde e, mais especificamente, o turismo de bem-estar. Assim, o principal questionamento dessa pesquisa é: Houve uma maior procura pelo turismo de bem-estar após a pandemia de COVID-19? Para responder à tal questão, procurou-se atender ao seguinte objetivo: realizar uma análise do que vem sendo estudado e publicado sobre esse tema em uma das principais bases de dados, a Scopus (Elsevier) e uma análise observacional do que tem sido postado no Instagram para promover as experiências de turismo de bem-estar. A pesquisa foi realizada em outubro de 2022 e como resultado observou-se que houve um aumento significativo das menções às possibilidades de experiências nesse segmento, tanto no que se refere aos estudos sobre essas temáticas, como às postagens realizadas no Instagram, mostrando que é uma atividade que apesar do crescimento, ainda tem muito potencial, principalmente após o arrefecimento da pandemia. A limitação de pesquisa foi a revisão em apenas uma base de dados e sugere-se como estudos futuros a ampliação dessa análise e acredita-se que a pesquisa no Instagram em mais um idioma de largo alcance mundial também poderá ser relevante.Palavras-chave: Turismo de bem-estar. Experiência. Hedonismo. Reabilitação. COVID-19.
Editorial
Authors: Zouain Deborah Moraes
Published: December 2022

Prezados leitores,É com grande prazer que apresentamos o terceiro número da Revista Acadêmica Observatório de Inovação do Turismo do ano de 2022!Aproveitamos para lembrar que, desde o ano de 2019, a revista passou a ter três números por ano (abril, agosto e dezembro).Tenham uma ótima leitura!
LINGUISTIC FEATURES OF THE CANARY DIALECT IN THE CONTEXT OF THE SPANISH-SPEAKING COUNTRY
Authors:   Taras Shevchenko national University of Kyiv, Bugayova Catherine
Published: December 2022

The article deals with the the main linguistic features of the Canary dialect, historical and socio-cultural factors that influenced its emergence and further development. As one of the main difficulties in mastering Spanish is the variety of national variants and dialects of Spanish, this article deals with the Canary language as a separate dialect area, with its peculiarities of functioning and considers its relationship with the norm of the Castilian version of Spanish.
SYNTAX TRANSFORMATIONS OF FOCUS INVERSION IN THE UKRAINIAN TRANSLATION OF THE MAP AND THE TERRITORY BY M. HOUELLEBECQ
Authors:   Kyiv National Linguistic University, Filonenko Nataliia
Published: December 2022

The article analyzes the peculiarities of translation of narrative sentences with inversion with locative and temporal adverbs, adverbial syntagms or circumstances of time and place in the initial position from the perspective of cognitive perceptual factors reflecting reality in this type of constructions, highlights the logic of on the author's intention, as well as establishes the patterns of choice of appropriate syntactic construction when translating the sentences with the type of inversion under study. One of the main tasks of the translator is to reproduce the author's style, in particular when translating the texts of modern popular writers, whose works are translated into many languages. In fiction, French authors use the stylistic potential of certain types of syntactic constructions to convey implicit content. The task of conveying both explicit and implicit meanings in translation determines the use of syntactic constructions that would be equivalent to syntactic constructions of the original text, that is a translational aim to create symmetry of meanings of syntactic units of the original text and translation. Inversion in narrative sentences with adverbial syntagms or circumstances with locative and temporal meanings is often used by modern French authors because of their expressive effectiveness. These constructions are used in the narrator's speech in order to shift the focus of the reader's attention to important information for the author and to outline the statics and dynamics of the situation described by the author. A comparison of sentences with focal locative and temporal inversions and the corresponding sentences of the translated text shows that the translator follows the logic of the author of the work and uses the word order that focuses the reader on relevant information.
“Together We Are Strong”: Emergency Associations for the Protection of Germany's Cultural Heritage
Authors: Jedlitschka Rainer
Published: December 2022

This article presents an overview of the creation and development of emergency associations for the protection of archives, libraries, and museums in Germany. This is a response to several wake-up calls, notably the Elbe floods of 2002, the destruction by fire of a significant portion of the Duchess Anna Amalia Library in Weimar in 2004, and the collapse of the Cologne City Archive building in 2009. The emergency associations have come together on a voluntary basis to offer mutual support in the event of natural and human-made disasters.

Drawing on the experience of the Augsburg association founded in 2015, the author explains the role and success of the new networks. Annual meetings have consolidated regional and nationwide collaboration, and deepened experience and preparedness. Training courses and major incident exercises with fire services as well as the German Federal Agency for Technical Relief form the bedrock of the cooperation.
Using Oral History to Study the Personal Digital Archiving Practices of Modern Soldiers
Authors: Hinton Andrew
Published: December 2022

Drawing on literature from personal information management studies and on the topic of documentation of American military experiences, this article aims to help the archival profession understand the personal digital archiving practices of modern soldiers. During the summer of 2019, the author conducted oral history interviews with US Army soldiers at Fort Hood to address the questions of what personal records soldiers keep of their military experience, what they do—if anything—to preserve them, and how they value them. This study found that both military and socio-technological factors contribute to a lack of digital recordkeeping among modern soldiers, that soldiers' reliance on social media as ad hoc digital preservation tools leads to poor digital preservation practices, and that a majority of soldiers do not see their digital records as worthy of future historical study. The article concludes with a discussion of actions that can address these issues.
Finding Aid Aggregation: Toward a Robust Future
Authors: Allison-Bunnell Jodi
Published: December 2022

Over the last twenty-five years, cultural heritage professionals have formed aggregations—of finding aids, digital object metadata, or related forms of description—in order to overcome barriers to creating and presenting structured, consistent, and interoperable description and to enable expanded access. Now most of these aggregators are struggling to update their infrastructure, meet user needs for access to archival collections, and engage with some of the most promising conceptual, technical, and structural advances in the field. In 2018–2019, the “Toward a National Archival Finding Aid Network” planning initiative identified what aggregation has accomplished, articulated the key challenges facing aggregators, identified which areas could benefit from collaborative work, and created a vision for that work. With the near-completion of a research and demonstration by the California Digital Library, “Building a National Finding Aid Network” (NAFAN), the project and the archival profession have an opportunity to learn from the past and transform access to cultural heritage. However, none of the large-scale aggregations in the United States present a viable model for sustainability. Sustainability will become possible if they overcome the factors that have limited the success of aggregation so far. These include an over-focus on implementing new technical standards and infrastructure and under-focus on the real limitations: lack of knowledge of end user needs and attempting to accomplish too much without the needed resources. By drawing on both the background research described in this article and the further research conducted during the current NAFAN project, this and other cultural heritage enterprises have an opportunity to create a future in which access to cultural heritage is equalized and expanded for both institutions and end users.
Simultaneous Manipulation and Imaging of Chemogenetically Induced Hydrogen Peroxide in Hardly Transfectable Endothelial Cells
Authors: EROĞLU Emrah
Published: December 2022

Hydrogen peroxide (H2O2) is a critical signaling molecule in vascular cells, which controls signaling events, yet it can cause pathological oxidative stress in excess. The lack of suitable tools undermined experimental approaches to study the role of oxidative eu- and distress in cellular ultra-locales. This study exploits a yeast-derived D-amino acid oxidase (mDAAO) as a chemogenetic tool to induce, visualize and test the cytotoxicity of H2O2 in hardly transfectable endothelial cells. Due to the poor transfectability of endothelial cells, lentiviral vectors have been used to generate cell lines stably expressing mDAAOs. mDAAOs are substrate-based chemogenetic enzymes that convert D-amino acids to their corresponding alpha-keto acids and generate H2O2 as a byproduct, which can be visualized with a novel ultrasensitive, and ratiometric H2O2 biosensor termed HyPer7. This study tested the suitability of two different D-amino acids, including D-alanine and D-methionine, to induce oxidative stress in endothelial cells. Live-cell imaging experiments unveiled that 10 mM D-methionine generated significantly higher and faster H2O2 signals than D-alanine. However, both D-amino acids induced comparable levels of cell death documented by a colorimetric cell metabolic activity assay (MTT). This study provides a guide for manipulating and monitoring the cytotoxic effect of H2O2 in endothelial cells.
Case Report of Development of Atypical Hemolytic-Uremic Syndrome in Pregnancy
Authors: Smirnova Elena A. , Kurtikova Ol'ga V.
Published: December 2022

Atypical hemolytic-uremic syndrome (aHUS) is an ultra-rare (orphan) disease with a progressive course, which is a systemic thrombotic microangiopathy resulting from uncontrolled activation of the alternative complement pathway. There exist the so called obstetric thombotic microangiopathies (pre-eclampsia, HELLP syndrome) which are considered as triggers causing development of aHUS in pregnancy in genetically predisposed female patients. Here, the main peculiarity of these pathologies is the improvement of the condition of the puerpera after delivery. In case of non-obstetric thombotic microangiopathies, delivery does not lead to regress of symptoms, on the contrary, microangiopathic process progresses with rapid development of multiorgan failure. The development of thrombotic thrombocytopenic purpura and aHUS in pregnancy may induce physiological changes in the organism of a pregnant woman. There occurs a build-up of the activity of von Willebrand factor with a parallel reduction of the activity of ADAMTS 13 enzyme (metalloprotease that cleaves its super-large multimers). This is probably a physiological adaptation of the body to minimize blood loss during childbirth. As a result of the imbalance, the risk of developing thrombotic microangiopathy increases by the end of II beginning of III trimester. The concept of chronic uncontrolled activation of the alternative complement pathway implies a genetic defect of regulatory proteins with increased formation of C5 convertase, increased release of C5a a strong chemoattractant, and of membraneattacking complex C5bC9, which leads to damage to endothelial cells, exposure of the subendothelial layer and thrombosis. The currently used drug eculizumab is a recombinant humanized monoclonal antibody that binds to the complement C5 protein and suppresses the activation of complement-mediated cell lysis. The article presents a clinical case of the development of aHUS in a patient during pregnancy, the main stages of diagnostic search are considered, routing is determined and the therapy used is justified.
Potentials of Minimally Invasive Technologies in Treatment for Early Gastric Cancer
Authors: Dylenok Aleksey A. , Rybachkov Vladimir V. , Malashenko Viktor N. , Kashin Sergey V. , Shybin Leonid B.
Published: December 2022

INTRODUCTION: Gastric cancer remains one of the leading causes of oncological morbidity and mortality.
AIM: To determine the effectiveness and safety of wedge resections of stomach in patients with early gastric cancer (EGC) in comparison with endoscopic intraluminal treatment methods.
MATERIALS AND METHODS: Assessment of the immediate and long-term (5 years) prognosis of 164 patients with EGC who underwent wedge resection of stomach and endoscopic intraluminal interventions was performed. One hundred twenty eight patients were operated on in the volume of endoscopic intraluminal mucosal resection or submucosal dissection (the mean age 68.5 9.2 years; men 53.7%). In 36 patients (the mean age 65.3 7.8 years; men 66.7%), according to gastroscopy in combination with chromogastroscopy, narrow-band magnification endoscopy, the tumor dimensions exceeded those recommended for endoscopic methods. Due to contraindications for classic resection interventions in such patients, wedge resections of the stomach were performed.
RESULTS: In the comparison groups there was no postoperative mortality, however, in the group with use of endoscopic methods, complications were noted (perforations of the stomach and bleeding). All the complications were eliminated endoscopically. In the group of wedge resections, there were no postoperative complications, but in the long-term result, the five-year survival rate was lower than in the group of endoscopic treatment (75.0% versus 92.2%; 2 = 8.10, p = 0.004) due to a more severe comorbid pathology in the patients of wedge resection group.
CONCLUSION: Safety and equal effectiveness of wedge gastric resections was established in the long-term oncological result in patients with EGC in comparison with intraluminal endoscopic methods.
Strain Partitioning within the Caribbean–North America Transform Plate Boundary in Southern Haiti, Tectonic and Hazard Implications
Authors: Calais Eric , Symithe Steeve J. , de Lépinay Bernard M.
Published: December 2022

Global Positioning System measurements and high-resolution offshore seismic data within the transform Caribbean–North American plate boundary in southern Haiti, Greater Antilles, show 6–7 mm/yr of plate boundary-normal shortening within a crustal sliver bounded to the south by the Enriquillo left-lateral strike-slip fault and to the north by a south-dipping reverse fault system offshore the northern coast of the Southern Peninsula of Haiti. This overlooked fault system, which we name “Jérémie–Malpasse” (JM), marks the overthrusting of the Cretaceous oceanic crust of the Caribbean basin of the Southern Peninsula over accreted terranes of island arc crust to the north. Geological and geodetic data are consistent with a tectonic model that reconciles recent observations of plate boundary-perpendicular shortening with ample geological evidence for purely strike-slip motion on the Enriquillo fault. This model also provides a framework to interpret the 2010 Mw 7.0 and 2021 Mw 7.2 earthquakes in southern Haiti, whose oblique slip mechanisms are indicative of a localized transpressional strain regime. These findings imply that regional seismic hazard maps must be updated to account for both the existence of the ∼350 km long JM fault system and for the possibility that future earthquakes in southern Haiti may occur on nonvertical faults with a significant component of reverse slip.
HYPER-LEONARDO HYBRINOMIALS
Authors: MERSİN Efruz Özlem , BAHŞİ Mustafa
Published: December 2022

The aim of this paper is to define hyper-Leonardo hybrinomials as a generalization of the Leonardo Pisano hybrinomials and to examine some of their properties such as the recurrence relation, summation formula and generating function. Another aim is to introduce hyper hybrid-Leonardo numbers.
Procjena agronomskih vrijednosti i stabilnost komponenti prinosa novostvorenih linija jaroga stočnog graška (Pisum sativum l.)
Authors: Krizmanić Goran , Ćupić Tihomir , Tucak Marijana , Horvat Daniela , Brkić Andrija , Beraković Ivica , Marković Monika
Published: December 2022

One of the most important tasks of breeders is to improve the properties of breeding material (varieties, lines) and to create a new genetic variability. The study goals were as follows: during two consecutive years (2019 and 2020), to evaluate the agronomic value of nine newly created spring breeding lines of fodder pea, as well as to evaluate the stability of yield components and to select the most promising genotypes for further breeding. The results of the study demonstrate that there are significant differences between the tested genotypes in the tested environments for most of the analyzed properties and that the variation of genotypes within the identified sources of experimental variation exerts the greatest influence . Based on the investigated property values, subsequent to stability evaluation the desirable genotypes L - OSMBK 1, L - OSMBK 3 – for the grain/plant yield L - OSMBK 1, L - OSMBK 8, L - OSMBK 3, L - OSMBK 9 – for the mass of 1,000 grains, and L – OSMBK 9 – for plant height were identified as the stable genotypes, with a high breeding and agronomic properties.
Teksturalna i senzorska svojstva ekstrudiranih kukuruznih snack proizvoda s dodatkom pčenice obogaćane cinkom i selenom
Authors: Kajić Nikolina , Jozinović Antun , Lončarić Zdenko , Ačkar Đurđica , Šubarić Drago , Horvat Daniela , Kovačević Marija , Heffer Hrvoje , Babić Jurislav
Published: December 2022

The aim of this paper was to investigate the influence of Zn‐ and Se‐fortified wheat flour addition to the corn grits at 90:10, 80:20, 70:30, 60:40 ratios on the hardness, fracturability, expansion ratio, bulk density, color, and sensory attributes of the extrudates. Extrusion was performed at three temperature profiles: 140/170/170 °C, 150/180/180 °C, and 160/190/190 °C. With an increase in the proportion of Zn‐ and Se‐ fortified wheat flour and temperature increase, all observed physical characteristics of extrudates decreased. The lightness of all the samples increased after the extrusion. The total color change increased with the addition of Zn‐ and Se‐fortified wheat flour. Sensory characteristics showed that the samples with a lower percentage of added Zn‐ and Se‐fortified wheat flour had better scores and acceptability, compared to the samples with a higher fortification ratio.
A study to assess the etiology, risk factors, distribution, characteristics and outcome of multisystem inflammatory syndrome in children in Hadoti region of Rajasthan
Authors: Jain Divya , Khandelwal Sunita
Published: December 2022

Background: Aim and objectives of the study was to assess the etiology, risk factors, distribution, characteristics and outcome of multisystem inflammatory syndrome in children (MIS-C) in Hadoti region of Rajasthan.Methods: A cross-sectional study was conducted, based on notified suspected cases of MIS-C with COVID-19. The records were then classified according to the definition of a ‘confirmed case. Treatment was also recorded immunoglobulin, antibiotics, corticoid, anticoagulant and oxygen supplementation. The outcome of the subjects was also recorded.Results: Majority of the subjects belonged to 1-6 years (56.6%) with 62.3% males and 37.7% females. Fever, rashes, cough, vomiting, abdominal pain, throat pain, hematuria and decreased appetite was present among 100.0%, 47.2%, 37.7%, 39.6%, 22.6%, 15.1%, 13.2% and 3.8% respectively. C-reactive protein, D-dimer, erythrocyte sedimentation rate (ESR), ferritin and lactate dehydrogenase (LDH) were present among 94.3%, 92.5%, 88.7%, 75.5% and 60.4% respectively. Discharge against medical advice (DAMA) was done for 5.7%, death among 7.5%, discharge among 84.9% and 1.9% were referred to higher centre.Conclusions: The risk of mortality was greater in MIS-C patients in LMICs despite reduced rates of ICU hospitalisation and use of mechanical ventilation. For the causation, ideal preventative and treatment strategies, and long-term results of the MIS-C patients, further proof is required.
Clinical, biochemical and echocardiographic characteristics in children with multisystem inflammatory syndrome associated with coronavirus disease: a tertiary care experience
Authors: Fernandes D’Sa Lorraine A. C. , Joshi Vaishali
Published: December 2022

Background: We describe the clinical, biochemical and echocardiographic characteristics in children diagnosed with multisystem inflammatory syndrome (MISC) temporally associated with severe acute respiratory syndrome coronavirus 2 (SARS-Co-V-2), admitted to a tertiary care hospital in Goa, India.Methods: This was a retrospective observational study conducted at Goa Medical College, Goa, India. Parameters including demographics, clinical features, laboratory markers, medications and outcomes were obtained from patient hospital records; analyzed for patients treated for MISC (as per WHO case definition) for a period of 11 months from 01 July 2020 to 31 July 2021.Results: 30 patients (18 males) with median age of 7 years (IQR: 2 months – 12 years) were included. The proportion of children with gastrointestinal symptoms was 20 (64.5%), shock was a presenting feature in 15 (48%) and coronary ectasia and/or low ejection fraction was seen in 12 children (38.7%).Conclusions: A high index of suspicion for the diagnosis of MIS-C in children presenting with fever and Kawasaki disease like symptoms or signs of shock is recommended; since early aggressive therapy with Intravenous Immunoglobulins and methylprednisolone can have favourable outcomes.
Relationship of aerobic fitness and self-reported physical activity with academic achievement among school children of Surat city, Gujarat: a correlation study
Authors: Shah Salvi S. , Diwan Shraddha J.
Published: December 2022

Background: Aerobic fitness (AF) and Physical activity (PA) has shown a numerous valuable effects on physical and mental health of school children. However, research on relationship of AF and PA with Academic achievement (AA) has been less explored in the developing countries. So the present study was undertaken to examine the relationship of AF and PA with AA among school children of Surat city, Western India.Methods: A total of 579 children aged between 10 to 14 years, were enrolled from 14 granted/nongranted schools of Surat city. Data on children’s demographics, anthropometric measures (height, weight, Body Mass Index), AF (20m shuttle run test) were abstracted. Information regarding head of the family, parents’ education, occupation and monthly income along with physical activity readiness questionnaire (PARQ) were also noted from the parents. PA was measured with cross culturally adapted English and Gujarati version of Physical activity questionnaire – children (PAQ-C). Children’s AA was measured by their recent examination results in mathematics, science, social study and language (Gujarati and English) subjects along with overall grades provided by the administrative services of the schools participating in the study. Spearmen’s correlation coefficient was used to assess relationship of AF and PA with AA among children.  Results: Overall, mean VO2max for 20m shuttle run test among the children was 35.33±2.20 ml/kg/minute. Results of the study showed a significant moderate positive association of AF (VO2max and no.of laps) and PA (PAQ-C) with mathematics (rho=0.46, p<0.0001 for VO2max, rho=0.51, p<0.0001for no. of laps, rho=0.42, p<0.0001 for PA) and significant weak positive association of AF (VO2max and no.of laps) and PA (PAQ-C) with science (rho=0.34, p<0.0001 for VO2max, rho=0.32, p<0.0001for no.of laps, rho=0.36, p<0.0001 for PA) ,English (rho=0.35, p<0.0001 for VO2max, rho=0.34, p<0.0001for no. of laps, rho=0.35, p<0.0001 for PA), Gujarati (rho=0.39, p<0.0001 for VO2max, rho=0.33, p<0.0001for no. of laps, rho=0.38, p<0.0001 for PA) ,social study (rho=0.22, p<0.0001 for VO2max, rho=0.32, p<0.0001for no. of laps, rho=0.36, p<0.0001 for PA)  and overall grades (rho=0.32, p<0.0001 for VO2max, rho=0.31, p<0.0001 for no. of laps, rho=0.34, p<0.0001 for PA) amongst all the children. All the correlations remain significant even after controlling socio-economical status and age.Conclusions: The present study concluded that AF and PA has more impact on mathematics subject compared to science, language, social study and overall grades among school children. Academic success is associated with higher level of CRF levels. So the schools should reflect the plans to progress AF and PA as part of their overall strategy for improving AA.