bluuebunny/crossref_metadata_2025 huggingface dataset:
Developing a Blockchain-Based Supply Chain System for Advanced Therapies: Protocol for a Feasibility Study (Preprint)
Authors: Lam Ching , van Velthoven Michelle Helena , Meinert Edward
Published: November 2019

BACKGROUND

Advanced therapies, including cell and gene therapies, have shown therapeutic promise in curing life-threatening diseases, such as leukemia and lymphoma. However, these therapies can be complicated and expensive to deliver due to their sensitivity to environment; troublesome tissue, cell, or genetic material sourcing; and complicated regulatory requirements.

OBJECTIVE

This study aims to create a novel connected supply chain logistics and manufacturing management platform based on blockchain, with cell and gene therapy as a use case. Objectives are to define the requirements and perform feasibility evaluations on the use of blockchain for standardized manufacturing and establishment of a chain of custody for the needle-to-needle delivery of autologous cell and gene therapies. A way of lowering overall regulatory compliance costs for running a network of facilities operating similar or parallel processes will be evaluated by lowering the monitoring costs through publishing zero-knowledge proofs and product release by exception.

METHODS

The study will use blockchain technologies to digitally connect and integrate supply chain with manufacturing to address the security, scheduling, and communication issues between advanced therapy treatment centers and manufacturing facilities in order to realize a transparent, secure, automated, and cost-effective solution to the delivery of these life-saving therapies. An agile software development methodology will be used to develop, implement, and evaluate the system. The system will adhere to the EU and US good manufacturing practices and regulatory requirements.

RESULTS

This is a proposed study protocol, and upon acceptance, grant funding will be pursued for its execution in 2021.

CONCLUSIONS

The successful implementation of the integrated blockchain solution to supply chain and manufacturing of advanced therapies can push the industry standards toward a safer and more secure therapy delivery process.

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/17005
Value Chain Analysis on Pigmented Rice: A Case Study in Sleman Regency, Special Region of Yogyakarta, Indonesia
Authors: Anindita Kilana Putri , Ismoyowati Dyah , Suwondo Endy
Published: November 2019

White rice has become the main source of carbohydrates, but in the last few years, red and black rice are getting more popular. Red and black rice can be an alternative food for people who wish to reduce the risk of diabetics due to its low glycemic index. Pigmented rice demand in Yogyakarta is continuously increasing. However, farmers are reluctant to plant pigmented rice because of their lower yields. Value chain analysis on pigmented rice is performed to provide the condition of the business’ performance for farmers who are not willing to work on pigmented rice yet. The objective of this study was to identify the main activities and to measure the performance of the value chain. The value chain performance was measured by calculating profit, marketing margin, and farmer’s share. In the business of pigmented rice nowadays, there are 5 actors involved, i.e. farmer, farmers group, association of farmers groups, distributor, and retailer. These five actors formed 5 value chains for red rice and 4 value chains for black rice. The main activities were cultivating, cropping, milling, sorting out, packing, and selling. The performance of the pigmented rice was as follows: on the red rice value chain, farmers earned the highest profit in each chain, except on the chain where the association of farmers groups was involved. The largest marketing margin was found on the farmer – association of farmer groups – retailer – end-user consumer chain. On the black rice value chain, farmers earned the highest profit in each chain, except on the chain where the farmers group was involved. The largest marketing margin found on the farmer – farmers group – distributor – retailer – end-user consumer chain. For both the red and the black rice value chain, the farmer’s highest share was obtained on the farmers – distributor – end-user consumer chain.
Extent of Commitment of Lebanese Banks to Principles of Governance (An Empirical Study)
Authors: El-Mousawi Dr. Hasan , Fakih Dr. Ibrahim
Published: November 2019

The novel inclination towards applying principles of governance in banks constitutes a great challenge to banks around the world, especially in developing countries. It is especially challenging for Lebanese banks to apply principles of governance because its economy is passing through a very delicate period. This paper aims at studying the extent of commitment of Lebanese banks to principles of governance according to Basel Committee. It is of great importance that Lebanese banks should be committed to these principles to be able to face present and future challenges since applying principles of governance enhances trust of investors, shareholders and other related parties in addition to related international organizations which are closely watching the Lebanese economy. The researchers utilized a five-point Likert Style questionnaire which includes 56 items and asked employees of 10 banks operating in Lebanon to respond to them. Among those employees were board members, executives, internal auditors and heads of departments. The research reached some important findings, most importantly that Lebanese banks are totally committed to principles of governance. This enables Lebanese banks to have a positive impact on investors, shareholders and other parties, which might enhance the bank’s competitive position and attract a greater number of investors, depositors and stockholders.
Нейросетевое моделирование содержания хлороформа в питьевой воде при водоподготовке
Authors: Юхно А.И. , Плуготаренко Н.К.
Published: November 2019

Работа посвящена применению нейросетевого моделирования в сфере водоподготовки. Разработана нейросетевая модель, способная прогнозировать концентрации хлороформа, образующиеся в ходе хлорирования питьевой воды, в зависимости от параметров качества воды. Проведена серия компьютерных экспериментов по исследованию влияния отдельных факторов на целевой параметр. Построенная нейросетевая модель дает возможность создания системы контроля над содержанием хлорорганических соединений в питьевой воде, тем самым обеспечивая условия более безопасного водопотребления.
Повседневные практические задачи требуют инновационных аналитических решений
Authors: Родченкова В.В.
Published: November 2019

Учебно-­научная химико-­аналитическая лаборатория РГУ нефти и газа (НИУ) имени И. М. Губкина – ​одна из ведущих в Российской Федерации испытательных лабораторий в заявленной области аккредитации. Больше двадцати лет под руководством академика РАН А. Г. Дедова ученые-­химики успешно решают самые сложные практические задачи по созданию методов контроля состояния окружающей среды, водных ресурсов, лекарственных препаратов, качества нефтепродуктов и др. Важное и очень востребованное направление работы – ​разработка экспресс-­методов и многокомпонентных тест-средств для контроля качества топлив и смазочных материалов. Об истории создания лаборатории, достижениях, практических результатах работы и планах на будущее рассказали руководитель – ​академик Алексей Георгиевич Дедов и заместитель руководителя лаборатории, ​менеджер по качеству, ​Делгир Андреевна Санджиева.
Авангард мирового аналитического оборудования
Authors: Обухова Е.Н.
Published: November 2019

Ежегодно в мире проходит огромное количество выставок и конференций, некоторые из них представляют особый интерес для специалистов в области аналитической химии, поскольку определяют направления развития отрасли. Два таких мероприятия прошли весной-­летом 2019 года в США: Питтсбургская конференция по аналитической химии и прикладной спектроскопии и ежегодная Конференция Американского масс-­спектрометрического общества. Тысячи ученых посетили конференции и следили за их программами в интернет-­трансляциях, а сопутствующие выставки собрали ведущих производителей аналитического оборудования и материалов.
XXI Менделеевский съезд по общей и прикладной химии: хроника событий
Authors: Ивашко С.В.
Published: November 2019

XXI Менделеевский съезд по общей и прикладной химии прошел с 9 по 13 сентября в Санкт-­Петербурге. Он стал ключевым событием 2019 года, официально объявленного Генеральной ассамблеей ООН Международным годом Периодической системы химических элементов. Съезд приурочен к 150-летию открытия Периодического закона химических элементов Дмитрием Менделеевым. Под эгидой ЮНЕСКО Международный год Периодической системы химических элементов проходит в России, Франции, Германии, Испании, США, Японии и сопровождается проведением научных конференций, тематических выставок, конкурсов молодых ученых и других мероприятий. Только в России по официальным данным их количество превысило 500.
Метод определения содержания примесей в трансформаторном масле по величине акустического коэффициента демпфирования
Authors: Крехова А.В.
Published: November 2019

Обсуждаются вопросы повышения надежности и увеличения срока службы трансформаторов. В контроле и диагностике состояния трансформаторов одним из перспективных является акустический метод обнаружения развивающихся дефектов. В его основе – регистрация акустических сигналов, которые возникают из-за присутствия примесей в трансформаторном масле. В статье приведены методика выполнения испытаний трансформаторного масла акустическим методом и способ обработки экспериментальных данных. В качестве критерия работоспособности по параметрам увлажненности и содержания целлюлозы рассматривается коэффициент демпфирования средой.
«СокТрейд» развивает собственное производство
Authors: Новиков Е.А.
Published: November 2019

Рассказывает генеральный директор компании «СокТрейд»
Евгений Анатольевич Новиков
Financiarización y Desarrollo: ¿Cómo pueden ponerse al día las economías emergentes?
Authors: Guizzo Danielle , Strachman Eduardo , Dalto Fabiano , Feijo Carmem
Published: November 2019

Las influencias de la financiarización sobre las economías emergentes han llamado mucho la atención sobre si estas naciones pueden o no superar sus limitaciones y promover niveles de desarrollo satisfactorios. Sin embargo, las posibilidades de superar el dominio financiero merecen mayor atención sobre lo que concierne a sus causas estructurales y las políticas alternativas. Este artículo tiene dos objetivos: a) formaliza tres características clave detrás de la financiarización de las economías en desarrollo, enfocándose en algunos elementos clave que diferencian la financiarización en las economías desarrolladas y emergentes: el comportamiento de la tasa de interés; la volatilidad del tipo de cambio y el dominio de la balanza de pagos. b) analiza algunas estrategias para que estos países superen los efectos de la financiarización en base a la hipótesis de aumentar el espacio de políticas, lo que permite a estas economías mantener la autonomía en sus políticas macroeconómicas y llevar a cabo políticas internas en un escenario integrado.

 
Financiarización, empleo y relaciones laborales en la industria automotriz en México
Authors: Marcial Flores Aurora
Published: November 2019

Aquí se abordan las discusiones teórico-conceptuales de la corriente heterodoxa para caracterizar el fenómeno de la financiarización en la industria automotriz. La revisión orienta la relocalización de los motivos, objetivos y necesidades de las corporaciones automotrices para desplazarlos del ámbito productivo al ámbito financiero.  También permite argumentar que las condiciones actuales del empleo y del sistema de relaciones laborales del segmento productivo automotriz en México son consecuencia del despliegue del fenómeno de la financiarización conducido por las corporaciones automotrices en el ámbito global. Se emplea el análisis empírico para mostrar que las estrategias corporativas son tendientes a incrementar el valor del accionista, esto es, a incrementar las ganancias de capital en los mercados financieros, a incrementar el pago de dividendos y el volumen de los rendimientos. Las consecuencias de lo anterior es el incremento de la volatilidad y la fragilidad del sector financiero, y la intensificación del cambio en las relaciones de poder entre el capital y el trabajo; en términos del argumento teórico, en favor del capital y en detrimento de la clase trabajadora.

  
Persepsi Konsumen pada Endorser Selebriti Produk Shampo Merek Pantene
Authors: Marsudi Marsudi
Published: November 2019

Tujuan penelitian ini adalah untuk mengetahui persepsi konsumen terhadap endorser selebriti produk shampo merek Pantene sekaligus variabel yang paling dominan berpengaruh terhadap persepsi konsumen diantara variabel visibility, credibility, attraction dan power selebriti yang digunakan sebagai konstruk dari variabel endorser. Dari hasil penelitian yang akan dilakukan diperoleh bahwa persepsi konsumen tinggi diperkirakan untuk penilaian pada attraction sebagai endorser produk shampo merek Pantene. Hal ini dapat dilihat dari nilai rata-rata skor indikator tersebut diperkirakan masuk pada kriteria tinggi. Indikator yang dimiliki selebritis diharapkan mempunyai daya tarik fisik/penampilan yang menarik, dan berkualitas baik dari segi kepribadian maupun kecantikan yang dimiliki endorser.
Investasi dan Daya Beli Menurunkan Ekspor? Data dari Asean 5
Authors: Pramuja Risky Angga
Published: November 2019

Tujuan dari penelitian ini untuk mengetahui kinerja investasi, daya beli, dan kurs, terhadap ekspor barang pabrik di ASEAN-5. Adapun hasil penelitian menunjukkan bahwa Investasi berpengaruh signifikan pada taraf 15%, artinya bahwa setiap peningkatan investasi lansung akan menurunkan ekspor pada negara ASEAN-5 di tahun 2010-2016. Begitu juga Paritas Daya Beli berpengaruh signifikan namun negatif, ini menggambarkan bahwa setiap terjadinya peningkatan peritas daya beli masyarakat, maka akan menurunkan ekspor barang, artinya selera masyarakat dalam mengkonsumsi barang lebih cendrung memilih barang produksi dalam negeri. Sedangkan kurs tidak berpengaruh signifikan, artinya bahwa perubahan harga yang terjadi secara gelobal tidak memberikan pengaruh terhadap ekspor barang.
The assessment of power influence of discharge flow from surges under conditions of hydrologically hazardous natural phenomena
Authors: Solovyev Alexander A. , Solovyev Dmitry A. , Shilova Liubov A.
Published: November 2019

Introduction. The analysis of studies on waves of translation and their dynamic effects on water infrastructure facilities indicates the incompleteness of accounting the dispersion component of wave motions in discharge flows. Existing analysis methods for the surge parameters with the dependence of the propagation velocity and wave pressure on the wavelength should be only considered as a rough approximation of the role of dispersion processes accompanying the surge propagation in river flows. The purpose of the research is to increase the accuracy of reliability analyses for equipment and auxiliary mechanisms of hydraulic structures and water facilities in the context of the growth of hydrologically hazardous natural phenomena in the form of surges.

Materials and methods. The article used an analytical method for calculating the wave motion parameters. It is based on determining the conditions for synchronism of jumps and discontinuities in the parameters of the medium state when passing through front surfaces. An option was suggested for using the frontal characteristics method for integrating equations of unsteady currents in open flows. The paper presented a scheme for solving the differential equations of unsteady motions and continuity of flows in river streams with surges in the presence of resistance forces.

Results. Analytical design relations were obtained for the velocity and power effects of surges with dispersion dependence on wavelength. An analysis of the obtained solutions is carried out by illustrating the dynamic effects of wave dispersion on water infrastructure facilities.

Conclusions. The suggested method of the more accurate analysis for the force impact of the discharge flow from surges on the structural elements of hydro-economic and water-transport facilities can be used to determine the reliability of hydraulic structures and water-transport facilities. The obtained analysis relations for determining the kinematic and dynamic characteristics of the dispersion of the surges are advisably recommended to supplement the existing regulatory documents on hydraulic engineering.
Nothing good happens after dark: the influence of temporal factors on motor carrier crash severity
Authors: Moody Misty , Nadler S Scott , Voss Doug
Published: November 2019

Motor carrier safety is a topic of great importance for both industry and makers of public policy. Regulatory agencies, such as the Federal Motor Carrier Safety Administration (FMCSA), regularly publish data detailing the circumstances surrounding roadway accidents. FMCSA’s Large Truck and Bus Crash Facts (LTBCF) data demonstrate an increase in accidents during daylight hours and on weekdays. Roadway risks are ever-present but differ by time of day and day of the week. These differences may potentially engender crashes of different severities at different times. This study analyzes FMCSA LTBCF data to determine when crashes of different severities are more likely to occur. Findings indicate that crashes resulting in property damage are more likely to occur during the day and on weekdays. However, fatal and injury crashes are significantly more likely during nights and weekends. Recommendations to improve safety outcomes are provided along with suggestions for future research.
Feasibility of warehouse drone adoption and implementation
Authors: Companik Edward , Gravier Michael J , Farris M Theodore
Published: November 2019

While aerial delivery drones capture headlines, the pace of adoption of drones in warehouses has shown the greatest acceleration. Warehousing constitutes 30% of the cost of logistics in the US. The rise of ecommerce, greater customer service demands of retail stores, and a shortage of skilled labor have intensified competition for efficient warehouse operations. This takes place during an era of shortening technology life cycles. This paper integrates several theoretical perspectives on technology diffusion and adoption to propose a framework to inform supply chain decision-makers on when to invest in new robotics technology.
Adolescent smoking behavior and communication with parents: Depression as a mediator and gender as a moderator
Authors: Chen Xieping , Xie Qian , Yang Yuting
Published: November 2019

Parent–adolescent communication is assumed to be an important factor affecting adolescent smoking behavior. However, the inner mechanism accounting for this association has still not been clarified in research. Our purpose in this study was to examine the relationships between
parent–adolescent communication, adolescent smoking behavior, and depression, as well as gender differences in the relationship between depression and adolescent smoking behavior. Participants were 1,134 students at 6 junior high schools in China who completed the Parent-Adolescent Communication
Scale, the Epidemiological Studies Depression Scale, and the Smoking Behavior Test. Results showed that parent-adolescent communication had a significant negative effect on adolescent smoking behavior and depression partially mediated the relationship between parent–adolescent communication
and adolescent smoking behavior. In addition, gender moderated the relationship between depression and adolescent smoking behavior. Overall, these findings may help to promote better understanding of the relationship between parent–adolescent communication and adolescent smoking behavior.
How implicit mindset influences consumers’ perception of company engagement with product complaints online
Authors: Lee Sang Yeal , Lee Ji Young , Ahn Hongmin , Moon Jang Ho
Published: November 2019

Consumer complaints posted on social media can quickly escalate a problem to become a crisis for a company. Although many companies engage with consumer complaints on various social media platforms, understanding of the mechanisms underlying consumer perceptions of such engagement remains
limited. Thus, we examined how company engagement and consumers’ implicit mindset (i.e., implicit beliefs about the nature of human traits) influences consumer attributions regarding complaints posted online. Through an experiment (N = 356 participants) we showed that (a) company engagement
with consumer complaints led to positive responses, potentially reducing the likelihood that negative events will become crisis situations, and (b) this effect was mediated by consumer perception of company responsibility. Further, the mediated relationship between company engagement and outcome
of responding to complaints through the degree of perceived company responsibility was contingent on the consumers’ mindset (i.e., a moderated mediation effect), showing the importance of consumers’ implicit mindset to online complaint behaviors.
TARGETING SELECTIVE TUMOURS BY DEPLOYING MAGNANO PARTICLES THROUGH NANJECTS: RECENT DRUG DELIVERY
Authors: PRIYANKA G  , RAJAJEYAKUMAR M
Published: November 2019

About 1.2 million new cancer cases have been diagnosed in 1998 worldwide and 2.5 million cases have been recorded in 2009 in India alone. Cancer is thus a major leading public problem that always remains first cause of death in both developed and developing countries (K.U. Devi 2009). Various promising treatment modalities for cancer starts from surgery or tumour removal, radiation, chemotherapy, immunotherapy, targeted therapy, employing hormones till stem cell transplantation procedures. Still, cancer is not completely eradicated from the body. One of the prime cons of these therapies is they over act during the treatment process. It damages the homeostatic balance of leading to increase in mortality rates widely across the world. Beyond the management of cancer the worse phase is pain experienced during the treatment of cancer. Such unrelieved pain has impact on their sleep, daily activities, food intake and at times their chronic pain leads them to commit suicide. Thus researchers have recently engineered a neo technique by impregnating Magnano particles into micro needles less than a hair follicle diameter to counteract tumour cells. Healthy cells will not be facing the damage amidst the targeted drug delivery to the cancerous cells. These non-toxic Magnano vehicles can overcome the debilitating systemic toxicities caused by cytotoxic chemotherapies. Moreover nano fine particles opt the Trojan horse mechanism to initiate tumour death. Its advanced property of possessing extensive surface-to-volume ratio is projected in its functionality through surface chemistries, especially when these nanoparticles are received in combinatorial with micro magnets. Thus Nanjects not only avoid side effects caused during cancer therapies but is also applicable for vaccine delivery which can eventually overcome fear and stress in Trypanophobia individuals.
Combining network theory with corporate governance: Converging models for connected stakeholders
Authors: Moro Visconti Roberto
Published: November 2019

Traditional corporate governance patterns are based on the interaction among composite stakeholders and the various forms of separation between ownership and control. Stakeholders cooperate around the Coasian firm represented by a nexus of increasingly complex contracts. These well-known occurrences have been deeply investigated by growing literature and nurtured by composite empirical evidence. Apparently, unrelated network theory is concerned with the study of graphs as a representation of (a)symmetric relations between discrete objects (nodes connected by links). Network theory is highly interdisciplinary, and its versatile nature is fully consistent with the complex interactions of (networked) stakeholders, even in terms of game-theoretic patterns. The connection between traditional corporate governance issues and network theory properties is, however, still under-investigated. Hence the importance of an innovative reinterpretation that brings to “network governance”. Innovation may, for instance, concern the principal-agent networked relationships and their conflicts of interest or the risk contagion and value drivers – three core governance issues. Networks and their applications (like blockchains, P2P platforms, game-theoretic interactions or digital supply chains) foster unmediated decentralization. In decentralized digital platforms stakeholders inclusively interact, promoting cooperation and sustainability. To the extent that network properties can be mathematically measured, governance issues may be quantified and traced with recursive patterns of expected occurrences.
Akomodasi Pesantren Terhadap Kebijakan Pendidikan Nasional
Authors: Burga Muhammad Alqadri , Arsyad Azhar , Damopolii Muljono , Marjuni Andi
Published: November 2019

This research aims to analyze the dynamics of Pondok Pesantren DDI Mangkoso in accommodating national education policies. The method of this research is qualitative with a phenomenological approach whose data is collected through observation, interviews, and documentation. The results of the research indicate that the status of Pondok Pesantren DDI Mangkoso as a traditional Islamic education institution still existed despite carrying out modern developments by maintaining five roles, namely: the place of transmission of classical Islamic sciences, daâ€™wah institutions, preserving Islamic traditions, the center of reproduction of scholars, and place of community service and development. Changes in the position of pesantren in national education policy during the period 1989-2018 have implications for the education policy of Pondok Pesantren DDI Mangkoso whose dynamics are divided into three stages, namely: institutional transformation, integration of curriculum, and application of a culture-basedÂ  inclusive paradigm. The form of accommodation for the national education policy by Pondok Pesantren DDI Mangkoso is the opening of formal education institutions at all levels of education. Various obstacles in the accommodation are the struggle of organizational culture and structure, limited resources, and lack of community participation.
Fenton process combined with precipitation for the removal of Direct Blue 1 dye: A new approach
Authors: Espinoza Isabel , Sandoval-Pauker Christian , Ramos Guerrero , Vargas Jentzsch , Muñoz Bisesti
Published: November 2019

Azo dyes are recalcitrant pollutants present in effluents of several industries. Due to their chemical stability, their degradation efficiency is not satisfactory by conventional technologies. Advanced oxidation processes, such as Fenton, can be applied for the removal of recalcitrant compounds. However, these methods are still costly. In this work, Fenton and precipitation treatments were combined for the removal (i.e., decolorization) of direct blue 1 (DB1), as an option to decrease operational costs. The individual treatments were studied separately using DB1 solutions 0.04 mmol L-1 to determine the effects of the parameters involved in each process. For the Fenton treatment, the c(Fe2+):c(H2O2) ratio that allowed the highest DB1 decolorization was 1:40. Regarding precipitation, the highest dye decolorization was achieved at a pH value of 6.0. Moreover, it was determined that a minimum c(DB1):c(Fe2+) ratio of 1:7.7 is needed to allow the decolorization of the dye by precipitation. Fenton assisted with precipitation tests were performed with DB1 solutions 0.09 mmol L-1 and using a c(DB1):c(Fe2+) ratio of 1:7.3 (which allows only partial precipitation of DB1). The results suggested that the dye can be treated by a Fenton process for 5 min and then precipitated to achieve the almost total decolorization of the dye (97.79 %). Azo dyes are recalcitrant pollutants present in effluents of several industries. Due to their chemical stability, their degradation efficiency is not satisfactory by conventional technologies. Advanced oxidation processes, such as Fenton, can be applied for the removal of recalcitrant compounds. However, these methods are still costly. In this work, Fenton and precipitation treatments were combined for the removal (i.e., decolorization) of direct blue 1 (DB1), as an option to decrease operational costs. The individual treatments were studied separately using DB1 solutions 0.04 mmol L-1 to determine the effects of the parameters involved in each process. For the Fenton treatment, the c(Fe2+):c(H2O2) ratio that allowed the highest DB1 decolorization was 1:40. Regarding precipitation, the highest dye decolorization was achieved at a pH value of 6.0. Moreover, it was determined that a minimum c(DB1):c(Fe2+) ratio of 1:7.7 is needed to allow the decolorization of the dye by precipitation. Fenton assisted with precipitation tests were performed with DB1 solutions 0.09 mmol L-1 and using a c(DB1):c(Fe2+) ratio of 1:7.3 (which allows only partial precipitation of DB1). The results suggested that the dye can be treated by a Fenton process for 5 min and then precipitated to achieve the almost total decolorization of the dye (97.79 %).
Influence of micro-rotation and micro-inertia on nanofluid flow over a heated horizontal circular cylinder with free convection
Authors: Swalmeh Mohammed , Alkasasbeh Hamzeh , Hussanan Abid , Mamat Mustafa
Published: November 2019

The addition of nanoparticles into conventional heat transfer fluids is one of the modern science techniques that offer better heat transfer performance. However, micropolar fluid model is not considered under these nanoparticles effects. Therefore, the main objective of this study is to explore the nanofluids to understand the microstructure and inertial characteristics of nanoparticles. In this paper, heat transfer flow of a micropolar nanofluid mixture containing copper (Cu) and silver (Ag) nanoparticles is investigated over a heated horizontal circular cylinder. The dimensionless governing equations are solved via an implicit finite difference scheme known as Keller-box method. The results of the nanofluid mixture are compared with those with a Newtonian fluid. The effects of different parameters on velocity, angular velocity and temperature are examined graphically for both Cu/Ag-water and Cu/Ag-kerosene oil. Results show that the heat transfer coefficient of the Cu/Ag-kerosene oil nanofluid mixture is larger than that of the Cu/Ag-water nanofluid, when comparison is based on a fixed value of the micro-rotation parameter.
Sleep and HbA1c in Patients With Type 2 Diabetes: Which Sleep Characteristics Matter Most?
Authors: Brouwer Annelies , van Raalte Daniel H. , Rutters Femke , Elders Petra J.M. , Snoek Frank J. , Beekman Aartjan T.F. , Bremmer Marijke A.
Published: November 2019

OBJECTIVE

Poor sleep has been identified as a risk factor for poor glycemic control in individuals with type 2 diabetes (T2D). As optimal sleep can be characterized in several ways, we evaluated which sleep characteristics are most strongly associated with glycated hemoglobin A1c (HbA1c).

RESEARCH DESIGN AND METHODS

A total of 172 patients with T2D completed 7-day wrist-actigraphy and sleep questionnaires. Linear regression was used to evaluate associations between sleep measures (total sleep duration, variability in sleep duration, midsleep time, variability in midsleep time, sleep efficiency, subjective sleep quality, and subjective insomnia symptoms) and HbA1c, individually and in concert.

RESULTS

Variability in sleep duration was individually most strongly associated with HbA1c (β = 0.239; P = 0.002; R2 = 4.9%), followed by total sleep duration (U-shaped: β = 1.161/β2 = 1.044; P = 0.017/0.032; R2 = 4.3%), subjective sleep quality (β = 0.191; P = 0.012; R2 = 3.6%), variability in midsleep time (β = 0.184; P = 0.016; R2 = 3.4%), and sleep efficiency (β = −0.150; R2 = 2.3%). Midsleep time and subjective insomnia symptoms were not associated with HbA1c. In combination, variability in sleep duration, total sleep duration, and subjective sleep quality were significantly associated with HbA1c, together explaining 10.3% of the variance in HbA1c. Analyses adjusted for covariates provided similar results, although the strength of associations was generally decreased and showing total sleep duration and subjective sleep quality to be most strongly associated with HbA1c, together explaining 6.0% of the variance in HbA1c.

CONCLUSIONS

Sleep in general may be a modifiable factor of importance for patients with T2D. The prevention of sleep curtailment may serve as a primary focus in the sleep-centered management of T2D.
At-a-glance - Twenty years of diabetes surveillance using the Canadian Chronic Disease Surveillance System
Authors: LeBlanc Allana G. , Gao Yong Jun , McRae Louise , Pelletier Catherine
Published: November 2019

In 1999, the Government of Canada, along with the provinces and territories, established the National Diabetes Surveillance System (NDSS) to track rates of diabetes in Canada. The NDSS used a novel method to systematically collect and report national diabetes data using linked administrative health databases. The NDSS has since evolved to become the Canadian Chronic Disease Surveillance System (CCDSS) and provides information on over 20 chronic conditions. This At-a-glance report provides the most up-to-date CCDSS information on diabetes rates in Canada. Currently, 8.8% of Canadians (9.4% male, 8.1% female, aged one year and older) live with diabetes, and approximately 549 new cases are diagnosed each day. Since 2000, the age-standardized prevalence rate has increased by an average of 3.3% per year. The age-standardized incidence rate has remained relatively stable, and all-cause mortality rates among those with diabetes have decreased by an average of 2.1% per year. This suggests that people are living longer with a diabetes diagnosis.
Aperçu - Vingt ans de surveillance du diabète grâce au Système canadien de surveillance des maladies chroniques
Authors: LeBlanc Allana G. , Baker Melissa , Gao Yong Jun , McRae Louise , Pelletier Catherine
Published: November 2019

En 1999, le gouvernement du Canada, en collaboration avec les provinces et les territoires, met sur pied le Système national de surveillance du diabète (SNSD) afin de suivre l’évolution des taux de diabète au Canada. Le SNSD utilise alors une nouvelle méthode pour recueillir et communiquer les données nationales sur le diabète de façon systématique, au moyen de bases de données administratives sur la santé reliées entre elles. Depuis, il a évolué pour devenir le Système canadien de surveillance des maladies chroniques (SCSMC) et fournit de l’information sur plus de 20 maladies chroniques. Cet article présente les données les plus à jour du SCSMC sur les taux de diabète au Canada. Actuellement, 8,8 % des Canadiens (9,4 % d’hommes et 8,1 % de femmes d’un an et plus) sont atteints de diabète, et environ 549 nouveaux cas sont diagnostiqués chaque jour. Depuis 2000, le taux de prévalence normalisé selon l’âge a augmenté en moyenne de 3,3 % par année, le taux d’incidence normalisé selon l’âge est demeuré relativement stable et les taux de mortalité toutes causes confondues chez les personnes atteintes de diabète ont diminué en moyenne de 2,1 % par année. Cela laisse entendre que l’on vit plus longtemps avec un diagnostic de diabète.
PERLINDUNGAN HUKUM BAGI PEKERJA ANAK DI INDONESIA
Authors: Izziyana Wafda Vivid
Published: November 2019

Fenomena pekerja anak di Indonesia dewasa ini merupakan persoalan yang  kompleks, berdimensi pada faktor ekonomi, sosial, dan budaya yang sudah ada sejak berabad-abad. Permasalahan  ekonomi pada keluarga merupakan persoalan dominan yang mengharuskan anak untuk  bekerja demi menunjang ekonomi keluarga. Pekerja anak saat ini tidak bisa di pungkiri, menurut Undang-Undang Nomor 13 Tahun 2003 tentang Ketenagakerjaan secara jelas telah melarang anak dibawah 18 tahun untuk bekerja. Hal Ini menggambarkan upaya perlindungan hukum bagi hak anak, namun kondisi masyarakat, maka Undang-Undang Nomor 13 Tahun 2003 membolehkan anak berumur 13 tahun sampai 15 tahun untuk melakukan pekerjaan ringan sepanjang tidak mengganggu perkembangan dan kesehatan fisik, mental, dan sosial dengan persyaratan (Pasal 69).  Disamping itu Undang-Undang Nomor 35 Tahun 2014 tentang  Perubahan atas Undang-Undang Nomor 23 Tahun 2002 tentang Perlindungan Anak mengamanatkan untuk memberikan perlindungan yaitu perlindungan khusus bagi anak yang dieksploitasi secara ekonomi termasuk pekerja anak (Pasal 66). Dengan adanya berbagai peraturan perundang-undangan yang terkait dengan upaya melindungi pekerja anak dapat memberikan kepastian hukum dalam upaya perlindungan hukum bagi pekerja anak di Indonesia
Lathraea squamaria L., novedad para la flora palentina (España)
Authors: Alonso Redondo Raquel , De Paz Canuria Elena , Ruiz de Gopegui Antonio , García González Marta Eva
Published: November 2019

Lathraea squamaria L., new for the Palencia ﬂora (Spain)Palabras clave. Lathraea L., corología, Palencia, España.Key words. Lathraea L., chorology, Palencia, Spain.
Anthina flammea Fr. (Deuteromycota, Fungi) en El Bierzo (León, N.O. España).
Authors: Bello Justina , Lence Carmen , Acedo Carmen
Published: November 2019

Anthina flammea Fr. (Deuteromycota, Fungi) from El Bierzo (León, NW Spain)Palabras clave. Anthina flamea, Deuteromycota, hongos mitosporicos, León, España.Keywords. Anthina flamea, Deuteromycota, mitosporic fungi, León, Spain.
Hoffmannseggia glauca (Ortega) Einfer (Fabaceae, Caesalpinioideae) nuevo metáfito en el Sur de la Península Ibérica (Málaga, España).
Authors: Cabezudo Baltasar , Casimiro-Soriguer Solanas Federico , Pérez-Latorre Andrés V. , Dana Elías , Ramírez Joaquín
Published: November 2019

Hoffmannseggia glauca (Ortega) Einfer (Fabaceae, Cesalpinioideae) a new metaphyte in Southern Iberian Peninsula (Malaga, Spain)Palabras clave. Hoffmannseggia, flora alóctona, Andalucía, España.Key wods. Hoffmannseggia, alien flora, Andalucía, Spain.
Nuevas citas de plantas acuáticas para la Laguna Redonda (Málaga), recientemente restaurada
Authors: Conde-Álvarez Rafael Miguel , López Figueroa Félix , Nieto José María , Ramírez González José Miguel , Ortega González Fernando , Rendón-Martos Manuel
Published: November 2019

New record of aquatic plants from the “Laguna Redonda” (Málaga), a pond recently restoredPalabras clave. Plantas acuáticas, laguna, restauración de humedales, Laguna Redonda.Key Word. Aquatic plants, pond, wetland restoration, Laguna Redonda.
Carex castroviejoi Luceño & Jiménez Mejías (Cyperaceae), a new species from North Greek mountains
Authors: Jiménez-Mejías Pedro , Luceño Modesto
Published: November 2019

Carex castroviejoi Luceño & Jiménez Mejías (Cyperaceae), una especie nueva de las montañas del norte de GreciaPalabras clave. Grupo de Carex flava, Grecia, Montes Pindo, serpentinas, endemismo.Key words. Carex flava group, Greece, Pindus mountains, serpentines, endemic.
Diversité floristique des suberaies du Parc National de Tlemcen (Algerie)
Authors: Letreuch-Belarouci Assia , Medjahdi Boumediene , Letreuch-Belarouci Noureddine , Benabdeli Kheloufi
Published: November 2019

RESUME. Diversité floristique des suberaies du Parc National de Tlemcen (Algérie). L’analyse de la diversité floristique des forêts de Hafir Zariffet a révélé l’existence de 211 taxons appartenant à 65 familles et 164 genres. Le nombre de taxons endémiques et/ou rares inventoriés comporte: 1 endémique algérien,7 algéro-marocains, 11 ibéro-algéro-marocains, 7 sont endémiques d’Afrique du Nord et 11 sont des endémiques d’Afrique du Nord et de la Péninsule ibérique. Le nombre des taxons rares s’élève à 26 dont 9 sont en même temps rares est menacés. Des efforts urgents de protection doivent êtres consentis pour préserver le chêne liège ainsi que les espèces endémiques qui lui sont inféodées.Mots clés. Subéraies, inventaire, diversité, Parc National de Tlemcen, Algérie.SUMMARY. Flora diversity of cork oak forest in the National Park of Tlemcen (Algeria). The analysis of the floristic diversity of forest massif “Hafir-Zariffet” in the Tlemcen National Park has revealed the existence of 211 taxa which belong to 65 families and 164 genera. The number of taxa endemic and/or rare includes: 1 endemic algerian, 7 algero-moroccan, 11 ibero-algero-moroccan, 7 are endemic in North Africa and 11 are endemic in Iberian Peninsula and North Africa. The number of rare taxa is 26, 9 are at the same time threatened. Urgent efforts are required to preserve the cork oak as well as endemic species confined to it.Key words. Cork oak forest, inventory, diversity, National Park of Tlemcen, Algeria.
Nuevo híbrido del género Thymus (Labiatae)
Authors: Morales Ramón
Published: November 2019

A new hybrid in the genus Thymus (Labiatae) Palabras clave. Thymus x viteki, Th. vulgaris, Th. fontqueri, Lérida.Key words. Thymus x viteki, Th. vulgaris, Th. fontqueri, Lérida.
Una nueva combinación en Asteraceae. A new combination in Asteraceae
Authors: López Martínez Josefa , Devesa Alcaraz Juan Antonio
Published: November 2019

A new combination in Asteraceae Palabras clave. Asteraceae, Carlina, taxonomía, Península Ibérica, Islas Baleares. Key words. Asteraceae, Carlina, taxonomy, Iberian Peninsula, Balearic Islands.
Revisión taxonómica del complejo de Centaurea cyanus L. (Centaurea sect. Cyanus, Asteraceae) en la Península Ibérica. Taxonomic revision of the Centaurea cyanus L. complex (Centaurea sect. Cyanus, Asteraceae) in the Iberian Peninsula
Authors: Muñoz Adolfo Francisco , Devesa Juan Antonio
Published: November 2019

Español.  Se ha efectuado la revisión taxonómica de Centaurea sect. Cyanus en la Península Ibérica. Se reconocen seis táxones y se hacen dos nuevas combinaciones: C. triumfettii var. semidecurrens (Jord.) Muñoz Rodr. & Devesa y C. graminifolia (Lam.) Muñoz Rodr. & Devesa. Se aporta una clave para la identificación de los táxones, así como su descripción morfológica e información sobre la distribución geográfica, apetencias ecológicas, fenología y número cromosómico. English. A taxonomic review of Centaurea sect. Cyanus in the Iberian Peninsula was done. Six taxa are recognized and two new combinations are proposed: C. triumfetti var. semidecurrens (Jord.) Muñoz Rodr. & Devesa and C. graminifolia (Lam.) Muñoz Rodr. & Devesa. A key for the identification of taxa are provided, also their morphological description, information on geographical distribution, their ecology, their phenology and their chromosome numbers are given.
Anotaciones de Mariano La Gasca en la ‘Flora Española’ de J. Quer (1762-1764)
Authors: Pérez-Rubín Juan
Published: November 2019

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Aportaciones al conocimiento de la orquidoflora palentina (España). Contributions to the knowledge of the orchids of Palencia (Spain)
Authors: Ruiz de Gopegui Antonio , De Paz Elena , Alonso Raquel , Ferreras Noelia , García Raquel M. , Alonso Sara , Rodríguez Alberto , García Marta Eva
Published: November 2019

Contributions to the knowledge of the orchids of Palencia (Spain) Palabras clave. Orchidaceae, corología, conservación, Palencia, Castilla y León, España. Key words. Orchidaceae, chorology, conservation, Palencia, Castile and León, Spain.
Distribuição geográfica de Aphanodictyon papillatum Huneycutt ex Dick (Saprolegniales) no Brasil. Geographical distribution of the Aphanodictyon papillatum Huneycutt ex Dick (Saprolegniales) in the Brazil
Authors: De Sousa Rocha José de Ribamar , Páscoa Rodrigues Edílson , Pereira da Silva Hamanda Soares Viana , Alves de Sousa Lidiane Martins , Viera Barros Brenda Skally
Published: November 2019

Geographical distribution of the Aphanodictyon papillatum Huneycutt ex Dick (Saprolegniales) in the Brazil. Palavras-chave. Aphanodictyon papillatum, Brasil, fungo zoospórico. Key words. Aphanodictyon papillatum, Brazil, zoosporic fungi.
Don Kiraly: SLE: un enfoque didáctico para fomentar la emergencia de lenguas adicionales, trad. N. Gómez Hernández, München, 2019.
Authors: Cómitre Narváez Isabel María
Published: November 2019

Esta obra surgió inicialmente como una propuesta de traducción del libro de Don Kiraly y Sarah Signer, publicado en 2017, titulado Scaffolded language Emergence in the Classroom: From Theory to Practice, para el público hispanohablante y se transformó en un proyecto de coautoría de una nueva versión del citado libro dirigida al público de lengua castellana, y en especial, a docentes y futuros docentes de enseñanza de lenguas interesados en enfoques pedagógicos innovadores. La presente versión está dividida en dos partes: la primera parte describe los fundamentos teóricos y epistemológicos del enfoque SLE, y la segunda parte aborda las posibilidades de aplicación de dicho enfoque en el contexto hispanoamericano.
Effects of sacubutril/valsartan on nutritional status in heart failure with reduced ejection fraction
Authors: Dereli Seçkin , Bayramoğlu Adil , Kaya Ahmet
Published: November 2019

Background

Malnutrition commonly occurs in patients with heart failure with reduced ejection fraction (HFrEF). Sacubitril/valsartan, which is an AT1 neprilysin inhibitor, has been shown to reduce mortality and hospitalization in patients with HFrEF. However, its effects on nutritional status remain unclear.

Methods

Sacubitril/valsartan was initiated in 164 symptomatic patients with HFrEF receiving an optimal medical treatment with angiotensin inhibition (mean age: 63 ± 20 years; 120 males, 60% ischemic cause). The New York Heart Association (NYHA) functional class and nutritional statuses of the patients were evaluated at the switching to AT1 neprilysin inhibitor and at the 6th-month follow-up of the maximum sacubitril/valsartan dose using the geriatric nutritional risk index (GNRI), controlling nutritional status (CONUT) score, prognostic nutritional index (PNI), and prealbumin.

Results

After the sacubutril/valsartan treatment, a significant reduction in the number (%) of malnourished patients was observed according to CONUT (before 47% vs. after 7%, P < 0.001), GNRI (before 39% vs. after 19%, P < 0.001), PNI scores (before 36% vs. after 12%, P = 0.002), and prealbumin (before 41% vs. after 12%, P < 0.001). Also significant changes were observed at the baseline and follow-up in the mean scores of the three different nutritional indexes and prealbumin levels [CONUT: 2.68 ± 2.5, 1.02 ± 1.0 (P < 0.001); GNRI: 97.1 ± 9.7, 101.2 ± 5.9 (P < 0.001); PNI: 38.8 ± 4.8, 41.6 ± 3.7 (P < 0.001); prealbumin: 14.6 ± 6.9 mg/dl, 17.1 ± 5.2 mg/dl (P < 0.001)]. Overall, the patients exhibited a significant functional improvement following the initiation of sacubitril/valsartan: 23% of the patients improved by two NYHA classes, 48% improved by one NYHA class, and 39% remained stable.

Conclusion

In patients with HFrEF, the switch from angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker therapy to sacubitril/valsartan resulted in a significant improvement in both nutritional and functional statuses.