bluuebunny/crossref_metadata_2025 huggingface dataset:
Corpus Driven Analysis of the Coronavirus Prevention Handbook
Authors: Hakim Ayu Humairoh , Zamzani Zamzani
Published: August 2023

Information about coronavirus prevention is important to know because coronavirus as the global pandemic after being designated by the World Health Organization (WHO) for four years. The aim of this article is to find out linguistic evidences from the lexical aspects such as lexical items, lexical categories, lexical cohesion and lexical bundles. Then analyzed it through corpus-driven analysis using AntConc software, this software is employed to process the data. This research uses a mix method and concurrent embedded model, after that downloading the data, observation and documentation as technique of collecting data, while the technique of analysis data use converting and compiling data, reduction data classification data and display data. The results of the quantitative and qualitative analyses show the result of corpus driven analysis through AntConc show the most common of lexical and syntactical aspects such as word classes, and sentences patterns used in the coronavirus prevention handbook.  AbstrakInformasi tentang pencegahan virus korona penting untuk diketahui, karena virus korona sebagai pandemi global setelah ditetapkan oleh Organisasi Kesehatan Dunia (WHO) setelah berjalan selama satu tahun. Tujuan dari artikel ini adalah untuk mencoba mencari tahu bukti linguistik dari aspek leksikal dan sintaksis. Kemudian dianalisis melalui analisis berbasis korpus menggunakan aplikasi Antconc, perangkat lunak ini digunakan untuk memproses data. Penelitian ini menggunakan metode campuran dan model campuran tidak berimbang, setelah itu mengunduh data, observasi, dan dokumentasi sebagai teknik pengumpulan data, adapun teknik data analisis menggunakan data konversi dan penyusunan data, data klasifikasi data pengurangan dan data tampilan. Hasil analisis kuantitatif dan kualitatif menunjukkan hasil AntConc dan menunjukkan aspek leksikal dan sintaksis yang paling umum seperti kelas kata, dan pola kalimat yang digunakan dalam buku pegangan pencegahan virus korona.
Language Variations for Tourism Sectors around of English and Dutch Colonial Buildings: Sociolinguistics and Ethnolinguistics Studies
Authors: Mukarromah Inayatul , Zulaihah Sitti
Published: August 2023

The purpose of this research is to know the language variations through Sociolingustics and ethnolinguistics studies in the English heritage and colonial building areas. The approach used in this research is qualitative. The strategy of in this research designed by combining the qualitative research design from Lincoln (2003) with the descriptive qualitative research design from Permadi (2013). The research results in the emergence of code-mixing and code-switching in society. There are several languages are spread in those cultural heritage, such as: Chinese, Melayu, Arabic, Bugis, Maduresse and Indonesia. While, Banyuwangi has Oseng Language.Thus, the conclusion that it is necessary to understand the potential of the language used in society. In this case, not only the text but its use in social and cultural contexts because language does not only depend on its social aspects in the sense of how language is used in social contexts and culture but then how language finally can be an additinaol potention to support colonial tourism destination in Banyuwangi.  AbstrakTujuan penelitian ini adalah untuk mengetahui variasi bahasa melalui pendekatan sosiolingusitik dan ethnolingusitik di Kawasan cagar budaya Inggrisan dan dua bangunan kolonial. Pendekatan yang digunakan dalam penelitian ini adalah kualitatif. Strategi yang digunakan dalam penelitian ini dirancang dengan mengkomibansi antara desain penelitian kualitatif dari Lincoln (2003) dan desain kualitatif deskriptif Permadi (2013).  Hasil penelitian yang didapat bahwa terdapat campur kode dan alih kode dalam kehidupan di masyarakat. Ada beberapa bahasa yang tersebar dalam warisan budaya tersebut, seperti: Cina, Melayu, Arab, Bugis, Madura dan Indonesia. Dengan demikian, kesimpulan dalam penelitian ini adalah perlunya memahami potensi bahasa yang digunakan dalam masyarakat. Dalam hal ini, bukan hanya teksnya tetapi penggunaannya dalam konteks sosial dan budaya karena bahasa tidak hanya bergantung pada aspek sosial dan budaya saja tetapi bagaimana bahasa kemudian bisa dijadikan sebagai potensi tambahan untuk menunjang destinasi pariwisata kolonial di Banyuwangi.
Appraisal System on Twitter: An Attitudinal Analysis Toward Alleged Islamic Blasphemy Case of M Kece
Authors: Yuliyanti Ai Yeni
Published: August 2023

This study examines the public's assessment of an Islamic blasphemy case named M. Kece on Twitter. It is a qualitative descriptive study. The data is a public assessment regarding the Islamic blasphemy case named M. Kece on Twitter using Appraisal Theory (Martin & White, 2005). Focusing on Attitudinal Analysis, the result shows the Attitudinal Analysis in social media, precisely Twitter, on the alleged Islamic blasphemy of M. Kece. Judgment is the most dominant, with as much as 54% over Affect (19%) and Appreciation (27%). In all three, more than three fourth of the data are negative. This dominant negative appraisal of netizens of Twitter users shows the public's assessment of what M. Kece has done, namely the content of his YouTube channel, which was reported and imprisoned due to a blasphemy case. This study affirmed that all content creators must be careful about the content they post. On the other hand, the viewer also must be selective about the content they access on social media not to be misleading. AbstrakStudi ini mengkaji penilaian publik terhadap kasus penistaan agama Islam bernama M. Kece di Twitter. Penelitian ini menggunakan pendekatan deskriptif kualitatif. Data dalam penelitian ini adalah penilaian publik terkait kasus penistaan agama Islam bernama M. Kece di Twitter dengan menggunakan Appraisal Theory (Martin & White, 2005). Berfokus pada Analisis Sikap, hasilnya menunjukkan Analisis Sikap di media sosial, tepatnya Twitter, tentang dugaan penistaan agama Islam terhadap M. Kece. Afeksi adalah yang paling dominan, dengan sebanyak 54% di atas judgment (19%) dan Apresiasi (27%). Dari ketiga kategori ini, lebih dari tiga perempat data merupakan penialaian negatif. Dominasi penilaian netizen pengguna Twitter ini menunjukkan penilaian mereka terhadap apa yang telah dilakukan M. Kece, yaitu konten channel YouTube-nya yang dilaporkan dan dipenjara akibat kasus penistaan agama. Penelitian ini menegaskan bahwa semua pembuat konten harus berhati-hati dengan konten yang mereka posting. Di sisi lain, penonton juga harus selektif terhadap konten yang mereka akses di media sosial agar tidak menyesatkan.
Promotion of West Sumatra Tourism in the Creative Industry and Its Strategic Value in the Language of Promotion
Authors: Rovylendes Adjuoktoza , Arnailis Arnailis , Yusnelli Yusnelli , Murniati Murniati , Herdianto Ferry , Nofridayati Nofridayati
Published: August 2023

The advancement of tourism in Indonesia has been facilitated through various implicit and nuanced approaches, such as language-based activities and innovative sectors. The availability of promotional texts in the form of language games can be considered a strategic asset, as it can capture the reader's attention and sustain their interest throughout the text, particularly in the context of tourism. The study employed various methodologies such as data acquisition and gathering, data classification and evaluation, and recording the results. A comprehension strategy is a familiar approach wherein we focus on the textual representation of information. The data analysis findings indicate that the utilization of promotional texts in the form of language games possesses a certain degree of strategic significance. This value is exemplified notably through the existence of syntactic deviation, equivocal forms, phonetic wordplay, and the accuracy of vocabulary.  AbstrakKemajuan pariwisata di Indonesia telah difasilitasi melalui berbagai pendekatan implisit dan bernuansa, seperti kegiatan berbasis bahasa dan sektor inovatif. Ketersediaan teks promosi dalam bentuk permainan bahasa dapat dianggap sebagai aset strategis, karena memiliki potensi untuk menarik perhatian pembaca dan mempertahankan minat mereka sepanjang teks, khususnya dalam konteks pariwisata. Studi ini menggunakan berbagai metodologi seperti perolehan dan pengumpulan data, klasifikasi dan evaluasi data, dan pencatatan hasil. Strategi pemahaman adalah pendekatan yang akrab bagi kami, di mana kami memusatkan perhatian kami pada representasi informasi secara tekstual. Temuan analisis data menunjukkan bahwa pemanfaatan teks promosi dalam bentuk permainan bahasa memiliki tingkat signifikansi strategis tertentu. Nilai ini dicontohkan terutama melalui adanya penyimpangan sintaksis, bentuk samar-samar, permainan kata fonetik, dan keakuratan kosa kata.
Fenomena Alih Kode dan Campur Kode Berdasarkan Penggunaan Tingkat Tutur Bahasa Jawa Perajin Batik Kota Pekalongan
Authors: Pramandhani Vamelia Aurina , Trismanto Trismanto
Published: August 2023

Abstrak: Batik Pekalongan adalah batik yang banyak diminati oleh masyarakat Indonesia. Batik Pekalongan memiliki ciri khas yang unik dengan motif pesisir karena wilayah Pekalongan terletak di bagian utara pulau Jawa yang dekat dengan lautan. Dalam proses pembuatan batik pekalongan terdapat berbagai istilah dalam dunia batik. Pada saat peneliti melakukan wawancara dengan pemilik usaha batik, tanpa sengaja perajin memotong pembicaraan karena ingin menanyakan sesuatu tentang proses membatik. Karena tidak mengerti, pemilik usaha menerjemahkan kepada peneliti. Hal seperti inilah yang diteliti oleh penulis mengenai alih kode (code switching) dan campur kode (code mixing) pada perajin batik di Kampung Batik Pekalongan. Penulis menggunakan teori alih kode dan campur kode dari Haugen (1968). Penelitian kali ini menunjukkan hasil yaitu adanya pemakaian alih kode dan campur kode dalam komunikasi yang dilakukan oleh perajin dan pemilik. Penggunaan alih kode dan campur kode dimaksudkan agar peminat seni batik dapat memberi pemahaman istilah-istilah yang kerap muncul dalam proses pembuatan batik.Kata-kata kunci: Batik, code switching dan code mixing, bahasa Jawa Pekalongan Abstract: Pekalongan batik is one of batik type that is in high demand by the Indonesian people. Pekalongan batik has unique characteristic with a coastal pattern because the Pekalongan region is located in the northern part of Java island close to the ocean. In the process of making Pekalongan batik, there are various terms in the world of batik. When the researcher was conducting an interview with the batik business owner, the craftsman accidentally interrupted the conversation because he wanted to ask something about the batik process. Because they did not understand, the business owner translated to the researcher. Things like this that are being researched by the author are regarding code switching and code mixing of batik craftsmen in Pekalongan Batik Village. The author uses the theory of code switching and code mixing from Haugen (1968). The result shows that there was the use of code switching and code mixing in communications carried out by craftsmen and owners. The use of code switching and code mixing is intended so that batik art enthusiasts can understand the terms used in the batik making process.Keywords: Batik, code switching and code mixing, Javanese language Pekalongan
Kritik Sosial dalam Kumpulan Puisi Meratus: Nyanyian Rindu Anak Banua
Authors: Saefuddin NFN
Published: August 2023

Abstrak: Penelitian ini membahas bagaimana wujud kritik sosial dalam kumpulam puisi Meratus: Nyanyian Rindu Anak Banua. Tujuan penelitian ini menganalisis teks puisi yang mengandung kritik sosial. Puisi ini menyajikan bentuk kritik sosial yang dapat dijadikan catatan oleh pengusaha dan penguasa, termasuk pembaca. Ketiga puisi tersebut, isinya membahas, yaitu; 1) ajakan untuk masyarakat sekitar Gunung Meratus, 2) imbauan untuk masyarakat agar menjaga Gunung Meratus dan sekitarnya, 3) ajakan untuk masyarakat adat agar tetap semangat dan terus berdoa, 4) permohonan kepada Allah agar Gunung Meratus senantiasa terlindungi dari segala bentuk pengrusakan yang dilakukan oleh manusia yang tidak bertanggung jawab, 5) ajakan agar masyarakat memiliki keseriusan untuk merawat Gunung Meratus dari keserakahan atas kerusakan hutan, 6) ajakan agar masyarakat sekitar Gunung Meratus terhindar dari  bencana alam,  7) ajakan agar masyarakat tidak tinggal diam atas rusaknya Gunung Meratus akibat perusakan terhadap alam secara terus menerus, 8) ajakan untuk melawan pengrusak dengan segala kemampuan, dan 9) ajakan untuk menjadi penguasa dan pengusaha yang bijak. Penelitian ini menggunakan metode deskriptif-kualitatif. Metode deskriptif-kualitatif ialah suatu metode untuk memperoleh informasi tentang isi teks puisi yang mengandung kritik sosial.Kata kunci:  Kritik sosial, puisi Meratus Abstract: This study discusses how social criticism manifests in the poetry collection Meratus: Nyanyian Rindu Anak Banua. The purpose of this study is to analyze poetry texts that contain social criticism. This poem presents a form of social criticism that can be a reminder for businessmen and rulers, including readers. Those three poems discuss about 1) urging people around Mount Meratus, 2) encouraging people to protect Mount Meratus and its surroundings, 3) leading people to pray and never give up, 4) praying to the God so that Mount Meratus is always protected from all kinds of destruction done by irresponsible human, 5) urging people to care of Mount Meratus seriously from the greediness of forest destruction, 6) urging people to avoid Mount Meratus from natural disasters, 7) urging people to preserve Mount Meratus from all damages continously, 8) urging people to fight against destroyer the hardest way they could, and 9) urging people to be a wise ruler and businessman. This study uses descriptive-qualitative method. It is a method to obtain information about the content of the poetry that contains social criticism.Key words: Social criticism, Meratus poetry
Feto-maternal cholesterol transport regulated by β-Klotho–FGF15 axis is essential for fetal growth
Authors: Kobayashi Kanako , Iwasa Kazuko , Azuma-Suzuki Rika , Kawauchi Takeshi , Nabeshima Yo-ichi
Published: August 2023

β-Klotho (β-KL) is indispensable to regulate lipid, glucose, and energy metabolism in adult animals. β-KL is highly expressed in the yolk sac, but its role in the developmental stages has not been established. We hypothesized that β-KL is required for metabolic regulation in the embryo and aimed to clarify the role of β-KL during development. Here, we show that β-KL regulates feto-maternal cholesterol transport through the yolk sac by mediating FGF 15 signaling, and also that impairment of the β-KL–FGF15 axis causes fetal growth restriction (FGR). Embryos ofβ-klknockout (β-kl−/−) mice were morphologically normal but exhibited FGR before placental maturation. The body weight ofβ-kl−/− mice remained lower after birth. β-KL deletion reduced cholesterol supply from the maternal blood and led to lipid shortage in the embryos. These phenotypes were similar to those of embryos lacking FGF15, indicating that β-KL–FGF15 axis is essential for growth and lipid regulation in the embryonic stages. Our findings suggest that lipid abnormalities in early gestation provoke FGR, leading to reduced body size in later life.
Basonuclin-2 regulates extracellular matrix production and degradation
Authors: Orang Ayla , Dredge B Kate , Liu Chi Yau , Bracken Julie M , Chen Chun-Hsien , Sourdin Laura , Whitfield Holly J , Lumb Rachael , Boyle Sarah T , Davis Melissa J , Samuel Michael S , Gregory Philip A , Khew-Goodall Yeesim , Goodall Gregory J , Pillman Katherine A , Bracken Cameron P
Published: August 2023

Epithelial–mesenchymal transition is essential for tissue patterning and organization. It involves both regulation of cell motility and alterations in the composition and organization of the ECM—a complex environment of proteoglycans and fibrous proteins essential for tissue homeostasis, signaling in response to chemical and biomechanical stimuli, and is often dysregulated under conditions such as cancer, fibrosis, and chronic wounds. Here, we demonstrate that basonuclin-2 (BNC2), a mesenchymal-expressed gene, that is, strongly associated with cancer and developmental defects across genome-wide association studies, is a novel regulator of ECM composition and degradation. We find that at endogenous levels, BNC2 controls the expression of specific collagens, matrix metalloproteases, and other matrisomal components in breast cancer cells, and in fibroblasts that are primarily responsible for the production and processing of the ECM within the tumour microenvironment. In so doing, BNC2 modulates the motile and invasive properties of cancers, which likely explains the association of high BNC2 expression with increasing cancer grade and poor patient prognosis.
Regulation of hPCL3 isoforms’ ubiquitination by TRIM21 in non-small cell lung cancer progression
Authors: Xu Ye , Liu Wenhong , Jiang Xiawei , Li Junfeng , Liu Qingling , Su Fang , Ruan Shanming , Zhang Zhiqian , Tao Fangfang
Published: August 2023

Non-small cell lung cancer (NSCLC) is the main subtype of lung cancer. The role of hPCL3 isoforms, hPCL3S and hPCL3L, remains ambiguous. This study examines the functional implications of these isoforms in NSCLC, using lung cancer cell lines A549 and NCI-H226c for in vivo and in vitro analyses. The results indicate that elevated expression of both hPCL3S and hPCL3L correlates with diminished overall survival, although only hPCL3S levels are augmented in clinical NSCLC specimens. Inhibition of either isoform leads to reduced cell proliferation, invasion, and migration, with hPCL3S knockdown displaying superior effectiveness. Moreover, the findings reveal that TRIM21 interacts with both isoforms and mediates hPCL3S degradation through K48-linked ubiquitination in NSCLC cells. Conversely, TRIM21 does not facilitate hPCL3L degradation, despite forming K63-linked polyubiquitin chains. These observations highlight the divergent roles of hPCL3 isoforms in NSCLC and underscore the potential therapeutic value of targeting hPCL3S.
De novo network analysis reveals autism causal genes and developmental links to co-occurring traits
Authors: Miller Catriona J , Golovina Evgeniia , Wicker Joerg S , Jacobsen Jessie C , O’Sullivan Justin M
Published: August 2023

Autism is a complex neurodevelopmental condition that manifests in various ways. Autism is often accompanied by other conditions, such as attention-deficit/hyperactivity disorder and schizophrenia, which can complicate diagnosis and management. Although research has investigated the role of specific genes in autism, their relationship with co-occurring traits is not fully understood. To address this, we conducted a two-sample Mendelian randomisation analysis and identified four genes located at the 17q21.31 locus that are putatively causal for autism in fetal cortical tissue (LINC02210,LRRC37A4P,RP11-259G18.1, andRP11-798G7.6).LINC02210was also identified as putatively causal for autism in adult cortical tissue. By integrating data from expression quantitative trait loci, genes and protein interactions, we identified that the 17q21.31 locus contributes to the intersection between autism and other neurological traits in fetal cortical tissue. We also identified a distinct cluster of co-occurring traits, including cognition and worry, linked to the genetic loci at 3p21.1. Our findings provide insights into the relationship between autism and co-occurring traits, which could be used to develop predictive models for more accurate diagnosis and better clinical management.
Refining the genetic risk of breast cancer with rare haplotypes and pattern mining
Authors: Letsou William , Wang Fan , Moon Wonjong , Im Cindy , Sapkota Yadav , Robison Leslie L , Yasui Yutaka
Published: August 2023

Hundreds of common variants have been found to confer small but significant differences in breast cancer risk, supporting the widely accepted polygenic model of inherited predisposition. Using a novel closed-pattern mining algorithm, we provide evidence that rare haplotypes may refine the association of breast cancer risk with common germline alleles. Our method, called Chromosome Overlap, consists in iteratively pairing chromosomes from affected individuals and looking for noncontiguous patterns of shared alleles. We applied Chromosome Overlap to haplotypes of genotyped SNPs from female breast cancer cases from the UK Biobank at four loci containing common breast cancer-risk SNPs. We found two rare (frequency <0.1%) haplotypes bearing a GWAS hit at 11q13 (hazard ratio = 4.21 and 16.7) which replicated in an independent, European ancestry population atP< 0.05, and another at 22q12 (frequency <0.2%, hazard ratio = 2.58) which expanded the risk pool to noncarriers of a GWAS hit. These results suggest that rare haplotypes (or mutations) may underlie the “synthetic association” of breast cancer risk with at least some common variants.
Exploring the impact of dexamethasone on gene regulation in myeloma cells
Authors: Bessonneau-Gaborit Victor , Cruard Jonathan , Guerin-Charbonnel Catherine , Derrien Jennifer , Alberge Jean-Baptiste , Douillard Elise , Devic Magali , Deshayes Sophie , Campion Loïc , Westermann Frank , Moreau Phillipe , Herrmann Carl , Bourdon Jérémie , Magrangeas Florence , Minvielle Stéphane
Published: August 2023

Among glucocorticoids (GCs), dexamethasone (Dex) is widely used in treatment of multiple myelomas. However, despite a definite benefit, all patients relapse. Moreover, the molecular basis of glucocorticoid efficacy remains elusive. To determine genomic response to Dex in myeloma cells, we generated bulk and single-cell multi-omics data and high-resolution contact maps of active enhancers and target genes. We show that a minority of glucocorticoid receptor-binding sites are associated with enhancer activity gains, increased interaction loops, and transcriptional activity. We identified and characterized a predominant enhancer enriched in cohesin (RAD21) and more accessible upon Dex exposure. Analysis of four gene-specific networks revealed the importance of the CTCF–cohesin couple and the synchronization of regulatory sequence openings for efficient transcription in response to Dex. Notably, these epigenomic changes are associated with cell-to-cell transcriptional heterogeneity, in particular, lineage-specific genes. As consequences,BCL2L11-encoding BIM critical for Dex-induced apoptosis andCXCR4protective from chemotherapy-induced apoptosis are rather up-regulated in different cells. In summary, our work provides new insights into the molecular mechanisms involved in Dex escape.
A EXPERIÊNCIA ESTÉTICA E A CONSIDERAÇÃO DA DIGNIDADE HUMANA: O CASO DO MÉTODO APAC
Authors: Siqueira Gilmar , De Arêa Leão Júnior Teófilo Marcelo , Cangussu Dantas Cachichi Rogério
Published: August 2023

O objetivo deste artigo é explicar a analogia feita por Elaine Scarry (1999) e, em seguida, aplicá-la ao método APAC de execução penal. O problema da pesquisa pode ser formulado pela seguinte pergunta: em que medida o aspecto estético do encontro com outro ser humano pode fomentar o apelo da dignidade humana? O objeto jurídico investigado – viável para esta pesquisa – é o método APAC em sua origem e aplicação. O método de pesquisa, tal como o de Elaine Scarry, é o analógico. O caminho (metodologia) percorrido será o de explicar a analogia da autora para estendê-la ao método APAC. Isso será feito em duas seções. Esta pesquisa pode ser justificada em um sentido metodológico por sua tentativa de aproximar do direito – ou seja, trazer para a reflexão jurídica – um pequeno elemento da filosofia da arte: tanto a tese de Elaine Scarry quanto a tentativa de sua aplicação por meio da análise das pinturas de Georges Rouault – ainda no campo da arte – e do método APAC – já em âmbito propriamente jurídico.
JUSTIÇA RESTAURATIVA E ADOLESCENTE OFENSOR EM SITUAÇÃO DE RUA: REFLEXÕES À LUZ DO LIVRO CAPITÃES DA AREIA DE JORGE AMADO
Authors: Carvalho Almeida da Costa Daniela , Santos Lacerda da Silva Gabrielli , Uruga Oliveira Cássio Roberto
Published: August 2023

Apesar da existência de um sentimento generalizado de insatisfação com a Justiça Retributiva, que pode ser atribuído, primariamente, à sua impossibilidade de atingir os fins a que se propõe, percebe-se ainda um enraizamento da lógica punitivista na sociedade contemporânea. Desse paradigma não se exclui o tratamento dado ao adolescente ofensor em situação de rua, na medida em que existe um clamor pela intensificação da sua punição. Nesse contexto, o presente trabalho tem como objetivo chamar a atenção para as possibilidades contidas na Justiça Restaurativa para o acolhimento ao jovem em conflito com a lei em situação de rua e para o rompimento do ciclo de violência imposto pelo Estado, incorporando a comunidade no processo e rompendo com a lógica estigmatizante. Para atingir este fim, será utilizado o livro “Capitães da Areia” de Jorge Amado, na medida que a aproximação entre o campo jurídico e o literário permite ao jurista o rompimento com o senso comum teórico, estimulando a sua capacidade crítica e a renovação do seu olhar sobre as certezas que permeiam o campo jurídico. O método científico utilizado será o dedutivo, a pesquisa será qualitativa e as técnicas de pesquisa serão o levantamento bibliográfico e documental.
Contextualizing Mental Health Comorbidities in SUD Patients Leading to Increased Risk of Overdose: A Systematic Literature Review
Authors: Walji David , Li Emily
Published: August 2023

Introduction: Despite increased awareness of the risk associated with drug overdose, it remains a significant public health concern in North America. In the case of Substance Use Disorder (SUD), comorbid mental illness has been found to increase risk of overdose. This systematic review aims to identify, assess and contextualize common comorbidities associated with SUD that have contributed to overdose occurrences. Methods: A comprehensive literature search was conducted to identify major comorbidities associated with SUD. PubMed, Embase, MEDLINE, and Web of Science were utilized. Peer-reviewed primary studies were included if they examined the prevalence of SUD in conjunction with a comorbidity involving mental illness. To establish a correlation with real-world overdose cases, the collected data was compared with coroner data to determine if current drug and comorbidity research in literature was reflective of the most prevalent forms of overdose in the general population. Results were summarized following the PRISMA guidelines. Results: A total of 60 papers investigating SUD with a comorbidity involving mental illness comorbidity were identified. Alcohol and cannabis were the most frequently studied substances, while Depressive and Anxiety disorders were the most common mental illness comorbidities examined. Geographically, these findings were consistent with studies from the US. However, in Canada, opioids were the most extensively studied substances, with Depressive and Neurodevelopmental disorders being the most commonly investigated mental illness comorbidities. Discussion: Comparison with coroner data suggests that greater research focus should be directed towards substances with greater potential for harm and fatal overdose. This emphasis on specific drugs can help improve overall mortality rates among SUD patients with comorbid mental illnesses. In Canada, this could involve conducting further research on stimulants such as cocaine and methamphetamine, and in the US with fentanyl. Conclusion: A disconnect between the substances studied in the literature and their real-world impact was found. Bridging this gap is essential to develop evidence-based interventions for comorbid SUD. More research on SUD, mental health comorbidity and overdose trends are needed to improve relevance to real-world scenarios.
ANALISIS KONSUMSI ENERGI DAN EMISI GAS RUMAH KACA PADA PEKERJAAN KONSTRUKSI JALAN DENGAN PERKERASAN LENTUR DAN PERKERASAN KAKU
Authors: Lendra Lendra , Gawei Apria Brita Pandohop , Sintani Lelo
Published: August 2023

Tahapan pembangunan jalan dari tahap konstruksi ke tahap operasi, mengkonsumsi sejumlah besar energi serta menghasilkan emisi. Penelitian ini bertujuan menganalisis jumlah energi dan emisi gas rumah kaca (CO2) pada pekerjaan jalan dengan perkerasan lentur (aspal) dan perkerasan kaku (beton) dengan menggunakan pendekatan Life Cycle Assessment (LCA). Studi kasus dilakukan pada ruas jalan di Provinsi Kalimantan Tengah. Metode yang digunakan untuk mengestimasi konsumsi energi dan emisi Gas Rumah Kaca (GRK) yaitu metode Tabel Energy Use and GHG Emissions for Pavement Construction dan Metode Konversi Bahan Bakar yang mengacu pada prosedur standar Intergovernmental Panel on Climate Change (IPCC). Hasil perhitungan, dengan pendekatan LCA jumlah konsumsi energi untuk konstruksi perkerasan kaku berjumlah 612.16 GJ dan perkerasan lentur berjumlah 268.91 GJ. Hasil perhitungan total emisi menunjukkan perkerasan lentur sebesar 19949.38 kgCO2/km dan perkerasan kaku sebesar 45414.75 kgCO2/km. Kesimpulan penelitian ini bahwa perkerasan lentur lebih ramah terhadap lingkungan dan lebih berkelanjutan dibandingkan dengan perkerasan kaku.
TINJAUAN SINGKAT BIO-ELEKTROKINETIK REMEDIASI PADA TANAH TERCEMAR HIDROKARBON MINYAK BUMI
Authors: Madonna Sandra
Published: August 2023

Bioremediasi telah banyak diaplikasikan untuk pemulihan tanah yang tercemar hidrokarbon minyak bumi, namun dalam aplikasinya yang luas masih dibatasi oleh karakterisik polutan, karakteristik tanah dan karakteristik mikroba pendegradasi dalam beradaptasi pada lingkungan yang berbeda. Tantangan dalam bioremediasi tanah tercemar hidrokarbon minyak bumi selain kompleksitas senyawa polutan dan juga bersifat rekalsitran, sertatoksik sehingga polutan sulit terbiodegradasi dan menyebabkan laju degradasinya berjalan lambat. Lambatnya laju degradasi limbah organik dipengaruhi oleh enzim-enzim degradatif mikroba yang sulit mengkatalis reaksi degradasi limbah dari senyawa xenobiotik atau yang senyawa yang tidak alami, karakteristik senyawa pencemar yang sukar larut dalam air, dan mengandung senyawa toksik bagi mikroorganisma pendegradasi. Bioremediasi tanah tercemar hidrokarbon minyak bumi umumnya akan berlangsung dalam hitungan bulan, waktu degradasi tersebut dapat dipercepat dengan menggabungkannya dengan teknik elektrokinetikremediasi dan meningkatkan bioavailibiltas denganmelakukan biostimulasi pada tanah tercemar tersebut, sehingga remediasi dapat berlangsung dalam hitungan hari bahkan hitungan jam. Makalah ini memberikan ulasan tentang pegabungan teknologi remediasi untuk tanah yang terkontaminasi minyak bumi. Metode yang dibahas meliputi Bioremediasi dan Elektrokinetik remediasi yang dikaitkan denganefektifitas degradasi, waktu degradasi,kelebihan, kekurangan, dan prospek pengembangannya di masa depan. Penekanan pada makalah ini adalah tidak ada teknologi remediasi tunggal yang dianggap sebagai solusi terbaik untuk remediasi tanah yang terkontaminasi minyak bumi yang bersifat komplek
PERENCANAAN SISTEM PENGELOLAAN SAMPAH DI PASAR KERAMAT INDAH KUALA DUA KABUPATEN KUBU RAYA
Authors: Dikta Berta , Arifin Arifin , Winardi Winardi
Published: August 2023

Keadaan Pasar Keramat Indah dilihat pada kondisi kebersihan pasar masih kurang terjaga, banyaknya sampah berserakan di sekitar pasar serta tingginya jumlah volume sampah menyebabkan sampah berserakan diluar TPS sehingga diperlukan perencanaan sistem pengelolaan sampah yang benar. Perencanaan ini bertujuan untuk menghitung timbulan berat dan volume sampah serta komposisi sampah serta merencanakan sistem pengelolaan sampah. Perhitungan sampel sampah menggunakan teknik Purposive Sampling. Pengambilan dan pengukuran sampel sampah berdasarkan SNI 19-3694-1994 dilakukan selama 8 hari. Timbulan sampah organik sebesar 0,0022 m3/unit/hari dan sampah anorganik 0,0013 m3/unit/hari. Persentase komposisi sampah organik 62% dan  sampah anorganik 38%. Sistem pengelolaan sampah yang direncanakan berdasarkan aspek teknik operasional yaitu pemilahan sampah dilakukan mulai dari sumber dan dipilah antara sampah organik dan anorganik. Wadah individual digunakan untuk sampah organik dan sampah anorganik dan diletakkan pada masing-masing pedagang. Pengumpulan dilakukan pada siang hari jam 12.00 – 14.00 WIB dan dipindahkan oleh petugas kebersihan pasar pada kontainer terpilah  yang terletak di area depan pasar dengan volume sebesar 6 m3. Sampah yang telah terpilah diangkut dan dikelola menjadi pupuk kompos dan didaur ulang oleh pihak Bank Sampah Limbung Mandiri Kubu Raya. Perencanaan sistem pengelolaan sampah ini diharapkan dapat menyelesaikan permasalahan sampah di Pasar Keramat Indah.
ANALISIS SENSITIVITAS SIMULASI PARAMETER BOD, TSS DAN DO DALAM PEMODELAN KUALITAS AIR DENGAN MENGGUNAKAN QUAL2K
Authors: Pratama Mochamad Adhiraga , Sidabutar Caleb Patrick , Hakim Ridwan
Published: August 2023

QUAL2K merupakan instrumen yang paling banyak digunakan dalam menyimulasikan kualitas air sungai di Indonesia. Untuk mengoperasikannya, QUAL2K membutuhkan input dari berbagai parameter dan variabel dengan jumlah banyak sehingga pengguna biasanya menggunakan nilai default untuk menyederhanakan proses simulasi. Namun, kesesuaian penggunaan nilai deafult ini pada kasus sungai di Indonesia belum pernah dievaluasi. Penelitian ini bertujuan untuk menganalisis sensitivitas nilai default untuk parameter dan variabel input terkait dengan simulasi Biochemical Oxygen Demand (BOD), Total Suspended Solid (TSS) dan Dissolved Oxygen (DO) di DAS Citarum Hulu. Analisis sensitivitas lokal dilakukan untuk 13 parameter dan 7 variabel input dengan memvariasikan setiap nilai default sebesar 5% dan sensitivitasnya dievaluasi dengan indeks sensitivitas (SI). Hasil analisis sensitivitas untuk simulasi BOD menunjukkan bahwa faktor koreksi suhu BOD dan konsentrasi DO dalam diffuse source merupakan parameter dan variabel input yang paling sensitif. Sedangkan untuk simulasi DO, beberapa parameter yang paling sensitif adalah Faktor Koreksi Suhu Oksigen, Lebar Sungai, Koefisien Manning dan Faktor Koreksi Suhu BOD. Variabel dan parameter input yang paling sensitif untuk konsentrasi TSS adalah konsentrasi DO dalam diffuse source dan fitorespirasi inhibisi oksigen.
APLIKASI ANODA MAGNESIUM PADA PROSES ELEKTRODIALISIS UNTUK RECOVERY NUTRIEN LIMBAH URINE
Authors: Rum Mas Den , Anggrainy Anita Dwi , Bagastyo Arseto Yekti
Published: August 2023

Elektrodialisis untuk proses recovery nutrien dari urine sangat diminati pada satu dekade terakhir, karena dapat mengkonsentrasikan ion yang menjadi target untuk mendapatkan produk hasil recovery dengan tingkat kemurnian tinggi. Penggunaan magnesium sebagai anoda untuk proses elektrodialisis saat ini juga mengemuka. Anoda ini secara efektif dapat menghasilkan struvite tanpa memerlukan tambahan bahan kimia untuk penyesuaian pH larutan dalam reaksi presipitasi. Pada studi ini, efektifitas anoda magnesium untuk proses recovery nutrien dengan elektrodialisis diinvestigasi berdasarkan tiga variasi pH (8,5; 8,8; 9,0) dan dua variasi kuat arus (300 dan 450 mA). Tujuannya untuk mengevaluasi efisiensi recovery amonium dan fosfat, serta mengidentifikasi karakteristik presipitat. Selama eksperimen, penyesuaian pH larutan tetap dilakukan sesuai variasi pH awal (pH 8,5-9). Hasil menunjukkan bahwa recovery tertinggi amonium dan fosfat didapat pada pH 8.5. Sekitar 42% amonium dan 28% fosfat dapat diambil sebagai produk recovery masing-masing pada kuat arus 300 dan 450 mA. Lebih dari 90% brucite, 3% hydroxyapatite, dan 3% struvite dapat diidentifikasi sebagai produk presipitat.
EVALUASI PARAMETER FISIK, KIMIA DAN MIKROBIOLOGI AIR SUMUR BOR SEBAGAI SUMBER AIR BERSIH di KOMPLEKS PERUMAHAN SOLARIA KOTA GORONTALO
Authors: Mahmud Marike , Womtami Rahmawati , Husnan Rawiyah , Saleh Kasmat
Published: August 2023

Penduduk yang padat diperkotaan menyebabkan masyarakat membeli  perumahan, luas tanah yang kecil, menyebabkan masyarakat memilih sumur bor, sebagai sumber  air bersih masyarakat.  Tujuan penelitian ini adalah untuk mengevaluasi parameter fisik, kimia dan mikrobiologi air sumur bor  sebagai sumber air bersih untuk digunakan oleh masyarakat yang tinggal  di  Perumahan Solaria Kota Gorontalo dan penyebab air dapat tercemar. Pengambilan sampel dilakukan di Perumahan Solaria sebanyak 6 lokasi.  Sumur yang dijadikan sampel adalah sumur bor (Sumur suntik) terdiri dari Blok A,  B, C,  D,  E dan  F. Pengambilan sampel dilakukan  3 kali ulangan. Parameter yang diukur adalah fisik (suhu dan TDS), kimia (besi, mangan, kesadahan ) dan parameter mikrobiologi (E.Coli dan Coliform). Analisis fisik dilakukan secara insitu. Parameter kimia di analisis di LPPT UGM dan  mikrobiologi dilakukan pada Dinas Kesehatan Kabupaten Gorontalo. Kriteria kelayakan air menggunakan PMK 32 Tahun 2017. Hasil penelitian menunjukkan bahwa  parameter  Suhu dan TDS,   kesadahan dan e.coli memenuhi syarat. Parameter Mangan, Besi, Total Coliform tidak memenuhi PMK 32 Tahun 2017. Parameter Mangan dan Besi  tinggi karena kondisi alamiah tanah yang dilalui air. Parameter Total Coliform di atas baku mutu karena kondisi lingkungan disekitar.
IDENTIFIKASI TIMBULAN DAN NILAI EKONOMI LIMBAH ELEKTRONIK (E-WASTE) RUMAH TANGGA DI KOTA PONTIANAK
Authors: Mulyani Ilmi Citra , Akbar Aji Ali , Jati Dian Rahayu
Published: August 2023

Limbah elektronik mengalami penambahan jumlah yang cukup signifikan setiap tahunnya di Indonesia. Pada tahun 2019, Indonesia menghasilkan 1,6 Mt limbah elektronik, yang menjadikan Indonesia termasuk dalam sepuluh negara penghasil limbah elektronik terbanyak di dunia. Limbah elektronik memiliki potensi ekonomi karena mengandung logam berharga, seperti  emas, alumunium, dan tembaga. Penelitian ini bertujuan untuk menganalisis kategori dan timbulan limbah elektronik rumah tangga di Kota Pontianak dan menganalisis potensi ekonomi dari limbah elektronik tersebut. Metode yang digunakan adalah metode survey dengan jumlah responden sebanyak 163 KK. Setiap responden didata jumlah dan perlakuan dari limbah elektronik yang dihasilkan serta dihitung timbulan limbah elektroniknya menggunakan metode consumption and use. Hasil dari penelitian menunjukkan  kategori Small Equipment menjadi kategori limbah elektronik yang paling banyak dihasilkan yaitu sebesar 42 %, sedangkan Lamps sebesar 19%; Small IT 17%; Screens and Monitors 9%; Temperature Equipment 8%; dan Large Equipment 5%. Pada tahun 2021, rata-rata timbulan limbah elektronik yang dihasilkan Kota Pontianak dari sektor rumah tangga mencapai 492476,53 kg/tahun dan memiliki potensi ekonomi dari nilai jual sebesar Rp. 957.652.484,62.
PENGOLAHAN LIMBAH CAIR TAHU DENGAN TEKNOLOGI ROTARY ALGAE BIOFILM REACTOR (RABR) MENGGUNAKAN SIMBIOSIS ALGA BAKTERI DENGAN VARIASI KECEPATAN PUTARAN DISK
Authors: Jannah Miftahul , Elystia Shinta , Sasmita Aryo
Published: August 2023

Limbah cair tahu memiliki kandungan bahan organik yang tinggi, sehingga dapat memicu terjadinya penurunan kualitas perairan. Simbiosis alga bakteri adalah teknologi alternatif yang menjadi solusi dalam pengolahan air limbah. Rotary Algae Biofilm Reactor (RABR) diidentifikasi sebagai bioreaktor alternatif untuk pengolahan air limbah industri dengan kombinasi sistem suspended growth dan attached growth pada media disk. Penelitian ini bertujuan untuk mempelajari pengaruh kecepatan putaran disk dan waktu kontak pada proses RABR untuk penurunan kadar organik BOD dan COD. Penelitian dilakukan dengan memvariasikan kecepatan putaran yaitu 3 rpm, 5 rpm, dan 7 rpm serta waktu kontak 0, 1, 3, dan 5 hari untuk menyisihkan parameter BOD dan COD pada limbah cair tahu. Hasil dari penelitian menunjukkan efisiensi tertinggi selama proses pengolahan dalam menyisihkan parameter yaitu pada variasi kecepatan putaran disk 7 rpm di hari ke-5, dengan efisiensi penyisihan BOD 73,42% dengan konsentrasi awal 737,4 menjadi 196 mg/L dan COD 70,64% dengan  konsentrasi awal 981 mg/L menjadi 288 mg/L.
EMISI GAS RUMAH KACA DARI PENGELOLAAN SAMPAH DI JAKARTA, INDONESIA
Authors: Sekarsari Nindi , Kristanto Gabriel Andari , Dahlan Astryd Viandila
Published: August 2023

Pengelolaan sampah perkotaan yang masih bertumpu pada pembuangan akhir di TPA (landfill) merupakan masalah lingkungan yang serius di Jakarta, Indonesia. Sistem pengelolaan sampah perkotaan berkontribusi terhadap emisi gas rumah kaca (GRK) pada semua tahapan pengelolaannya. Studi ini bertujuan memberikan gambaran umum tentang praktik pengelolaan sampah di Jakarta dan mengkaji kontribusi pengelolaan sampah perkotaan terhadap emisi GRK. Pada akhirnya dapat diketahui hotspot emisi GRK dalam tahapan pengelolaan sampah perkotaan dan lokasi spasial penyebaran emisi GRK di wilayah Jakarta. Perhitungan emisi GRK dilakukan pada setiap kota dan kabupaten administrasi pada tahun 2022 menggunakan Emission Quantification Tool (EQT) version II oleh Institute for Global Environmental Strategies (IGES). Hasil studi mengestimasi emisi GRK dari pengelolaan sampah perkotaan Jakarta pada tahun 2022 sebesar 1.516,60 ribu ton CO2-eq/tahun dengan kontributor terbesar berada di Kota Administrasi Jakarta Barat sebesar 433,4 ribu ton CO2-eq/tahun dan yang terkecil berada di Kabupaten Administrasi Kepulauan Seribu sebesar 2,7 ribu ton CO2-eq/tahun. Secara total, emisi GRK dari pembuangan akhir di TPST Bantar Gebang (2.034,5 ribu ton CO2-eq/tahun) memberikan kontribusi emisi terbesar di wilayah Jakarta. Jumlah penduduk, rendahnya praktik pengurangan sampah dan pengolahan sampah mempengaruhi besaran emisi GRK yang dihasilkan.
Study of the parent material of soft winter wheat for breeding for grain quality
Authors: Kravchenko N. S. , Podgorny S. V. , Ignatieva N. G. , Chernova V. L.
Published: August 2023

The sources of valuable traits for targeted use in the breeding of new winter wheat varieties with improved quality traits are presented. The results of the evaluation of the parent material on the expression of economically valuable features in the collection samples of soft winter wheat are presented. The paper presents data on 31 varieties of different ecological and geographical origin. Field experiments were conducted in 2018-2020 in the breeding rotation under the conditions of the southern zone of the Rostov region. Quality indicators of the varieties: thousand grain weight, protein content, quantity and quality of gluten in the grain, grain unit, total vitreousness, baking properties were determined by standard methods and GOSTs. As a result of the clustering of varieties, it is shown that the breeding program to create adaptive varieties with high grain quality should include as basic parent material the varieties which are included in the 5th and 6th clusters L-19578 (Russia), Etana (Germany), Warwick (Canada), Akter (Germany), MV-15-09 (Hungary), Simonida (Serbia), GK Hollo (Hungary), Webster (Canada), Wisdom (Canada), No. 42 CIMMYT (USA), and KS 96 WGRC 37 (USA). These varieties showed good results in the southern zone of the Rostov region. The other varieties of the collection nursery are recommended to be included in the breeding work in accordance with the principle of complementarity, as mutually complementary varieties in the expression of a particular trait or property.
Veterinary support of the herd horse breeding: problems and solutions
Authors: Donchenko A. S. , Neustroev M. P. , Tarabukina N. P.
Published: August 2023

Developed immunobiological preparations for the prevention of infectious diseases in herd horses are presented. Infectious diseases of horses are registered in almost all countries in Asia, Europe and America. In Russia, Kazakhstan, Kyrgyzstan, and Mongolia, the most common diseases are strangles of horses, rhinopneumonia, and salmonella abortion, which cause significant economic damage to herd horse breeding. Various monovaccines are developed and produced in foreign countries, most of them have no use in Russia. We have found a simultaneous disease of mares with rhinopneumonia and salmonellosis, as well as young horses with rhinopneumonia, salmonellosis and strangles. In this regard, the development of monovaccines and combined immunobiological preparations is becoming an urgent problem. Immunogenicity of infectious vaccines should be enhanced by immunomodulators, especially in the extreme conditions of herd horse breeding. At a time when antibiotic-resistant strains of microorganisms are a problem, alternative antibacterial agents should be developed: probiotics and bacteriophages. Eight new microbial strains have been isolated, identified, and deposited in all-Russian collections. Sahabaktisubtil probiotic has been developed, which is used to prevent and treat dysbacteriosis, mycotoxicosis, strangles, leptospirosis, decontamination of manure. New effective vaccine preparations and “Yakutskaya Koumissnaya” starter culture have been developed that can be successfully used to increase the productivity of horse breeding in other regions of the Russian Federation and abroad. Scientific and technical documentation was prepared for inactivated vaccine against rhinopneumonia, combined bivalent and trivalent vaccines. The developed immunobiological preparations are protected by 48 patents for invention and can be used in other countries.
Investigation of load-displacement behavior of cement-coated geotextile reinforced soils
Authors: ÖZTÜRK Mitat , KAYADELEN Cafer , ALTAY Gökhan , ÖNAL Yakup
Published: August 2023

In this study, typical California Bearing Ratio (CBR) experiments were conducted to examine the behavior of cement-coated geotextile reinforced soils. For this purpose, firstly geotextile-reinforced then cement-coated geotextile-reinforced tests were carried out for sand soil and base material. The results of the experiments reinforced soils with geotextile were compared with the results obtained from the tests of reinforced soils with cement-coated geotextile. In addition, the test results of the unreinforced soil were compared with the reinforced conditions. The results of the experiments were evaluated in terms of load-displacement behavior and CBR values. In view of the this results, base material reinforced with cement-coated geotextile outperformed compared to the unreinforced case; however, geotextile reinforced base material demonstrated worse than the unreinforced case, up to 6 mm displacement. On the other hand, both the geotextile reinforced, and cement-coated geotextile reinforced cases outperformed the unreinforced case on sand soil. In addition, cement-coated geotextile reinforced cases demonstrated better performance compared to the geotextile cases on both sand soil and base material. In terms of CBR values, geotextile and cement-coated geotextile reinforced sand soil indicated improvements of 1.68 and 3.25 times, respectively. While the CBR value of the cement-coated geotextile reinforced base material increased by 59%, it decreased by 4% in the geotextile reinforced case.
Pediatric ANCA-associated vasculitis presented with various clinical findings mimicking IgA Vasculitis and IgG4-related disease: Two cases
Authors: Oktay Mehmet Ali , Akyuz Oktay Selin , Uzun Kenan Bahriye , Sunar Yayla Emine Nur , Öğüt Betül , Büyükkaragöz Bahar , Gezgin Yıldırım Deniz , Bakkaloğlu Sevcan A.
Published: August 2023

Granulomatous polyangiitis (GPA) is the most common anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV), characterized by necrotizing inflammation of small and medium-sized vessels. It can affect various organs, particularly the lung, kidneys, upper respiratory tract, ears, and skin. Diagnosis of AAV poses significant challenges due to its diverse clinical features. This report presents two interesting cases of GPA: one with rare ocular involvement, who subsequently developed end-stage kidney disease (ESKD), and the other with palpable purpura mimicking immunoglobulin A vasculitis, who relapsed with mastoiditis while in renal remission. Early and effective treatment can improve patient prognosis, highlighting the importance of increasing disease awareness during initial diagnosis and in pediatric AAV patients experiencing relapses.