bluuebunny/crossref_metadata_2025 huggingface dataset:
A Case Report The Evaluation of Malondialdehyde Level on Acne Vulgaris Treatment
Authors: Muhammad Ridlo  , Jusuf Nelva K.
Published: November 2022

Abstract: Acne vulgaris (AV) is a multifactorial disease of the pilosebaceous unit with varying degrees of severity, recurrent and characterized by polymorphic lesions. Recent studies have found that the etiopathogenesis of AV is caused by oxidative stress. Each factor that causes AV is interrelated and is under the control of hormones and immunity. Measurement of malondialdehyde (MDA) level in the blood becomes a biological marker or an indicator of cell and tissue damage caused by oxidative stress. Case: A 23-years-old female private employee visited the clinic for multiple comedones and papulopustular lesions scattered over cheeks, nose, and chin that spread to the whole face four months ago. There were multiple comedones, papules, pustules, nodules on the maxillary, nasalis, left and right zigomatic, mentalis and frontalis region. We also found multiple scars on the left and right buccal. She was diagnosed with Severe AV. Serum MDA level was measured according to the enzyme-linked immunosorbent assay (ELISA) method before and after therapy. She was treated with doxycycline 100 mg, 0.025% tretinoin cream, 5% benzoyl peroxide, 1.2% clindamycin gel, and broadspectrum sunscreen with SPF 50. Result: After eight weeks of treatment, there were noticeable improvements in acne lesions and overall healthier-looking skin. Serum MDA levels are decreased (22.6 nmol/ml  to 17.9 nmol/ml) as the impact of the therapy.

Keyword: Acne Vulgaris, Malondialdehyde, Oxidative Stress
Analisis pengelolaan sampah dengan prinsip 3R sebagai upaya penurunan volume sampah pada ibu rumah tangga di Kelurahan Labuhan Deli
Authors: Rahim Zikrina Irmaya , Indirawati Sri Malem
Published: November 2022

Permasalahan lingkungan yang menjadi isu nasional adalah permasalahan sampah. Upaya penurunan volume sampah ditingkat rumah tangga dapat dilakukan dengan penerapan prinsip 3R (Reduce, Reuse dan Recycle) dengan melibatkan partisipasi ibu rumah tangga. Penelitian ini dilakukan untuk mengetahui implementasi pengelolaan sampah dengan prinsip 3R sebagai upaya penurunan volume sampah pada ibu rumah tangga di Kelurahan Labuhan Deli. Metode dalam penelitian ini merupakan survei yang bersifat deskriptif untuk melihat gambaran pengelolaan sampah dengan prinsip 3R pada ibu rumah tangga di Kelurahan Labuhan Deli. Hasil penelitian menunjukkan responden merupakan ibu rumah tangga berumur 55-56 tahun  (37,8%), pendidikan terakhir SD (51%), pendapatan keluarga di bawah Rp. 3.000.000 (63,3%), suku melayu (72,4%)  dan memiliki jumlah anggota keluarga <5 orang (77,6%) dengan timbulan sampah rumah tangga yang dihasilkan dalam 6 hari adalah 397,5 Kg atau setiap harinya dihasilkan sampah rumah tangga 0,676 Kg/hari dan 0,166 Kg/orang/hari dengan jenis sampah organik sebanyak 90% dan sampah anorganik 10%. Komposisi sampah terbanyak adalah sampah makanan sebanyak 83,3%. Pengelolaan sampah dengan prinsip reduce pada sebagian besar ibu rumah tangga masuk kategori rendah yaitu 75 ibu rumah tangga (76,5%), pengelolaan sampah dengan prinsip reuse pada sebagian ibu rumah tangga masuk kategori sedang yaitu 46 ibu rumah tangga (46,9%), pengelolaan sampah dengan prinsip recycle pada sebagian besar ibu rumah tangga masuk kategori rendah yaitu 96 ibu rumah tangga (98%), dan pengelolaan sampah dengan prinsip 3R pada sebagian besar ibu rumah tangga masuk kategori rendah yaitu 88 ibu rumah tangga (89,8%). Kemudian hampir semua ibu rumah tangga tidak mengetahui adanya Peraturan  Daerah dan Peraturan Wali Kota Medan berkaitan dengan pengelolaan Sampah Rumah serta adanya denda sebesar 10.000.000 atau kurungan penjara selama 3 bulan bagi setiap orang yang membuang sampah sembarangan.
Hubungan tingkat religiusitas dan tingkat kecemasan mahasiswa keperawatan selama pandemi COVID-19
Authors: Tumanggor Roxsana Devi , Nasution Nikmal Hasanah
Published: November 2022

Mahasiswa menunjukkan beberapa gejala psikologis selama Pandemi COVID-19, seperti rasa takut terinfeksi COVID-19 dan kecemasan.  Riset menunjukkan bahwa religiusitas adalah faktor penting yang harus di integrasikan ke dalam intervensi intervensi keperawatan untuk mengurangi risiko faktor kecemasan maupun dampak psikologis lainnya.  Penelitian ini adalah penelitian cross-sectional yang bertujuan untuk menganalisis hubungan antara tingkat religiusitas dan tingkat kecemasan mahasiswa selama Pandemi.  Berdasarkan teknik proportional stratified random sampling didapatkan 87 orang mahasiswa keperawatan sebagai sampel penelitian.  Instrumen yang diujikan dalam penelitian ini adalah The Centrality of Religiosity Scale (CRS) dan kuisioner kecemasan terhadap COVID-19 yang sudah melalui uji validitas dan reliabilitas.  Data dianalisis dengan uji korelasi Pearson untuk analisis hubungan kedua variabel dan menentukan distribusi frekwensi karakteristik sampel yang diteliti.  Hasil penelitian ini menunjukkan bahwa lebih dari 90% sampel adalah perempuan, dan tiga diantaranya pernah terinfeksi dengan COVID-19.     Berdasarkan hasil uji statistik untuk mencari hubungan dengan uji Korelasi Pearson menunjukkan hubungan kuat antara religiusitas dan kecemasan terhadap COVID-19. Hasil analisis statistik diperoleh koefisien korelasi -0,404 dengan P 0,00<0,05. Nilai koefisien korelasi menunjukkan terdapat hubungan negatif yang signifikan, artinya semakin tinggi religiusitas maka semakin rendah kecemasan terhadap COVID-19.
Postur Kerja dan Keluhan Musculoskeletal Disorders Pada Pemanen Sawit di PT. Inti Energi Kaltim Kabupaten Berau
Authors: Sultan Muhammad , Isnaniah Saputri Annisa , Ramdan Iwan Muhamad
Published: November 2022

Proses panen kelapa sawit masih dilakukan secara manual dengan mengandalkan tenaga manusia dan dilakukan secara berulang-ulang berpotensi menimbulkan keluhan Musculoskeletal Disorders (MSDs). Penelitian ini bertujuan mendeskripsikan keluhan MSDs yang dirasakan pemanen sawit karena postur kerja yang tidak ergonomis. Pengumpulan data dilakukan pada bulan Juni-Juli 2021 di PT. Inti Energi Kaltim dengan jumlah sampel 35 pemanen sawit. Instrumen yang dipergunakan dalam pengumpulan data keluhan pemanen sawit adalah kuesioner Nordic Body Map (NBM) dan penilaian postur kerja dengan metode Rappid Entire Body Assestment (REBA). Data selanjutnya dianalisis secara deskriptif dan disajikan dalam bentuk tabel distribusi frekuensi disertai narasi. Hasil penelitian diketahui bahwa postur kerja pemanen sawit yang berisiko rendah mengalami MSDs sebanyak 5,7%, berisiko sedang 65,7%, dan berisiko tinggi sebanyak 28,6%. Praktik postur kerja yang berisiko mengakibatkan 35 orang pemanen (100%) mengalami keluhan MSDs terbanyak pada bahu kanan 22,9% dan keluhan sangat sakit pada bagian kaki kiri dan kanan 11,4%. Oleh karena itu, disarankan kepada pemanen sawit sebaiknya memperhatikan posisi postur tubuh saat bekerja hingga menemukan postur kerja yang ergonomis agar tidak menimbulkan keluhan yang berkepanjangan.
RESISTANCE AND PRODUCT QUALITY OF RABBIT USING PROBIOTICS «ENTERONORMIN DETOX»
Authors: Korh O. V. , Aksonov Ie. A. , Petrash V. S. , Platonova Nataliia , Smetana A. I.
Published: November 2022

To increase the productivity of animal meat, various probiotic complexes are widely used, which have a stimulating effect on the body of animals, as well as participate in the normalization of intestinal microbiocenosis and increase the resistance of farm animals.
The study was conducted to study the effects of the probiotic drug «Enteronormin Detox».Probiotic is a biologically active supplement based on bacterial strains. Probiotics include typical representatives of the normal microflora of the large intestine of animals: bifidobacteria, lactic acid bacteria, streptococci. Probiotics are aimed at the competitive exclusion of opportunistic bacteria from the list of intestinal microflora, which distinguishes them from antibiotics.
The experiment involved a population of rabbits of meat and skin productivity - breed ober. Two groups of repair young rabbits (females) control and experimental (4 heads each) were formed.
The basic diet for these groups was the same and consisted of compound feed PC 90 lux. The difference in feeding between groups of rabbits was the additional introduction to the main diet of rabbits of the experimental group of probiotics «Enteronormin Detox» at the rate of 0,5 g per 1 kg (according to the manufacturer's recommendations). The probiotic contained the bacteria Enterococcus spp. 1–5×10⁷ CFU/g, Bacillus subtilis spp. 1–5×10⁶ CFU/g, Lactobacillus spp. 1–5×10⁶ CFU/g, chitosan, yeast autolysate, ground mustard, ground garlic, ground cinnamon, zeolite. Preliminary assessment of the chemical composition and quality of feed.
The use of this probiotic has improved the resistance of animals and increased preservation during the rearing period and has had a positive effect on the growing intensity and meat productivity of rabbits.
HISTORICAL RETROSPECTION OF SCIENTIFIC RESEARCH WITH PROBLEMS OF REPRODUCTION IN LIVESTOCK SCIENTISTS OF SCIENTISTS OF THE INSTITUTE OF LIVESTOCK INSTITUTE NAAS (XX CENTURY)
Authors: Kunets Victoria
Published: November 2022

An attempt is made in the historical context to comprehensively assess the contribution of the Institute of Animal Husbandry NAAS in the development of biotechnology, to identify priority developments of scientists of the Department of Biotechnology of Reproduction of Farm Animals as one of the main domestic centers of research on farm animals. Track the evolution of industry basic and applied research as a result of the work of scientists in the scientific field for the needs of livestock practice.
During the study period (1932-1999) the institution changed its name several times: Southern Institute of Dairy Science (1930-1934), Ukrainian Research Institute of Cattle (1934-1935), Ukrainian Research Institute of Animal Husbandry (1935-1956) , Research Institute of Animal Husbandry of the Forest-Steppe and Polissya of the Ukrainian SSR (1956–1992), Institute of Animal Husbandry of UAAS (1992–2010), now - Institute of Animal Husbandry of NAAS.
The formation of scientific research on the problems of artificial insemination dates back to 1932-1941. In the period of postwar reconstruction (1946-1948), scientific topics are characterized by more in-depth development of topics and experiments. The period of the highest creative activity of scientists in 1949–1990 - the existing and new methods of artificial insemination were improved. With the opening of state breeding stations and artificial insemination stations, the widespread use of this method in the practice of animal husbandry began. IV Smirnov's work was the impetus for the development of methods for freezing and long-term storage of sperm of broodstock. Embryo transplant work has been developed. The embryo has been established to implement the latest advances in farm animal biotechnology and to significantly expand the scope of international scientific contacts. At the beginning of the period of revival of Ukrainian statehood: 1991 - 1999 the issues of animal reproduction theory and further improvement on this basis of technologies for obtaining, cryopreservation and use of gametes and zygotes in artificial insemination and embryo transplantation, as well as development of more efficient biological environments and technical means new technologies.
SHARIAH AND MEDICAL MEASURES TO PREVENT THE EMERGING CORONA (COVID-19): AN ANALYTICAL STUDY
Authors: Abdul Rab Muneer Ali , Hasan Baidar Mohammed Mohammed , Gunardi Setiyawan , Hoque Mesbahul
Published: November 2022

The affliction of worshippers is a fixed Sunnah that has been passed by Allah in all of His creation. Allah has in his Noble Book, reported many types of calamities that plague His servants, and from this affliction: epidemics such as plague. People have known epidemics and plagues since ancient times, and it still applies to people to this day, all people witnessed Covid-19. Allah would not send down a disease to His servants except that He sent down a cure for it, Therefore, it is imperative for the Islamic nation to follow the instructions and measures urged by the Islamic religion, especially since medical practitioners have not found any effective treatment to prevent the infection. Even though it has reached the level of vaccines, but the transmission of infection has not been prevented. Therefore, these measures and instructions remain the mainstay of prevention and protection from it. This research aims to clarify the Shariah and medical preventive measures (Covid-19), and study them as an analytical study. To achieve this goal; the researcher followed the inductive and analytical approach, The researcher concluded that among the Shariah measures to prevent epidemics are: quarantine, fleeing from lepers, avoiding handshakes, purification, placing a hand or a garment over the mouth when sneezing, fermentation of vessels and potting of pots, abstinence from immorality and disobedience, enjoining good and forbidding evil, and adherence to supplications and remembrances. Similarly, among the medical measures to prevent the corona epidemic are the following: taking care of hygiene, washing hands, using disinfectants, wearing masks and gloves, social distancing, and applying home quarantine for those infected with colds, avoid direct contact with them.

Keywords: Shariah, medica, measures, protection, (Covid-19).
THE REGULATION OF HALAL LABEL IN NON-PACKAGED FAST-FOOD PRODUCTS IN INDONESIA ONLINE BUSINESS
Authors: Azizah Siti Nur
Published: November 2022

This research aims to understand the implementation of Halal certification regulation and the responsibility of the producer along with the authority of halal certification institution toward the non-packaged, ready-to-eat products in Indonesia. This research used a normative juridical method with a qualitative approach to observe the regulations related to product halalness. This result showed that halal label strive to guarantee the ingredients and the production process from the beginning until the end. The production tools should be divided between tools used for halal and non-halal products and storage. The implementation of halal labeling on non-packaged ready-to-eat products can be pushed by some factors, including having a national campaign program, consistent in halal certification procedure, providing access to SMEs actors for the easy and affordable halal certification process, and cooperation between the product owner and online application to give halal certification with the operational business requirements. Therefore the synergy of all parties in the implementation and supervision of halal certification is needed to create a significant change in online business in Indonesia.
إشكالات متاع البيت: بين الحلول الفقهية والنص القانون الجزائر
Authors: Mahrouk Karima
Published: November 2022

من المسائل الخلافية الماسة بالأسرة النزاع حول متاع البيت لاسيما ملكيته، وهي الملكية التي قد يدعيها كل من الزوجين، أو أحدهما وورثة الآخر، أو ورثتهما معا في حال وفاتهما. وقد عالج المشرع الجزائري هذه المشكلة في نص المادة 73 ق.أ.ج بإقراره أنه: "إذا وقع نزاع بين الزوجين أو ورثتهما في متاع البيت، وليس لأحدهما بينة فالقول للزوجة أو ورثتها مع اليمين في المعتاد للنساء، والقول للزوج أو ورثته مع اليمين في المعتاد للرجال. والمشتركات بينهما يتقاسمانها مع اليمين". ويعد طريق الاثبات له خصوصية استدعته الطبيعة الخاصة لمنازعات الواقعة على متاع البيت. تهدف الدراسة إلى بيان اهم الإشكالات التي يثريها متاع البيت بين الزجين او ورثة أحدهما وكيف تصد ى الفقه والقانون لها محاولا وجود حلول ترجحيه للحد منها. استخدمت الباحثة منهج البحث العقائدي لتحليل الوثائق ذات الصلة بعنوان الدراسة. من خلال المادة 73 قانون الأسرة المذكورة أعلاه نلاحظ أن المشرع وضعها في الفصل الثاني المتعلق بآثار الطلاق وهنا نوجه النقد على أساس أمرين، الحديث هو نزاع بين مطلقين حول أثاث بيت الزوجية ومنه المسألة انحلال الزواج بالوفاة تخضع لقواعد الميراث المنوه عنها شرعا وقانونا. كان على المشرع اختيار المصطلح الصحيح فمنازعات متاع البيت تثور عند الطلاق يجعل من الزوجية منفكة وبالتالي يسقط عن المرأة المطلقة مصطلح "الزوجة" كما يسقط عن الرجل المطلق مصطلح "الزوج". توصي هذه الدراسة أن هناك أمر ضرورة الاحتفاظ بالفواتير والوصولات التي تمكنها من إثباتما اقتنته أثناء الحياة الزوجية وأن النزاع إذا لم يكن بينها وبين زوجها قد يكون مع ورثته حول هذا المتاع. توسيع مجال الإثبات في متاع البيتواجتهاد القضاء في إيجاد حلول أخرى لما يثيره.
SHARIAH-BASED SUFISM IN THE MODERN ERA: A LOOK AT THE WORK OF SHAYKH ABDULLAH BIN BAYYAH
Authors: Farrar Salim
Published: November 2022

This article examines the legal (sharʿī) validity and practical relevance of Sufism in the modern era through exploring the life and works of the contemporary Mālikī scholar, Shaykh ʿAbdullāh Bin Bayyah. Famous for his works in Mālikī Fiqh, Uṣūl al-Fiqh and global work with Muslim minorities (especially Fiqh al-ʿAqalliyāt), Shaykh bin Bayyah is less well-known for his Sufism. And yet, the life and works of the religious figurehead of a network that extends from West and North Africa, and the Gulf countries, to the United Kingdom and the west coast of the United States of America, provide an illuminating window on some forms of contemporary Sufism. Drawing upon official biographies, secondary literature, a personal interview, and a key, as yet unpublished, text, Al-Mākhidh ʿalā al-Taṣawwuf (The Criticisms of Sufism), the author argues Bin Bayyah has a distinctive (though not necessarily unique) practical approach to Sufism that is most relevant to our times. Not only does it help provide a balanced, tolerant, and learned antidote to religious extremism, which is firmly rooted in the Syariah, his practical Sufism also lays the foundations of a path towards civic contribution of Ṣūfī communities in fields as diverse as education, prison reform and peace-making.
Secondary Grouting Pressure Limit of Shield Tunnels in Loess Strata Based on Bolt Shear Behavior
Authors: Feng Haolan , Ye Fei , Wen Xiaobao , Han Xingbo , Liang Xing , Lei Pengfei
Published: November 2022

A loess stratum was selected as the research object, assuming that the slurry diffuses in a hemispherical shape during secondary grouting. Based on the unified strength theory describing the failure characteristics of loess and the critical condition of bolt shear failure, the critical pressure value of the secondary grouting in loess strata was determined theoretically. The reliability of the theoretical analysis was verified by the numerical modeling realizing the large deformation of formation and the dynamic injection of slurry. The critical grouting pressure of 821.80 kPa of theoretical calculation was obtained. Comparing the results of the numerical simulation analysis, it was found that the critical grouting pressure calculated using the theoretical equation had a safety index of 1.14. Bounded by βu (the ratio of expansion radius RP of soil plastic zone to the expansion radius Ru of the slurry) equal to 2.65, the water pressure at the grouting port is the main factor affecting the upper limit of critical grouting pressure when it is less than 2.65, and the effective internal friction angle of soil layer is the main factor when it is greater than 2.65. The influence of matric suction on the upper limit of the critical grouting pressure can be ignored.
Effect of Physical Activity Interventions in Autism Spectrum Disorder
Authors: Yılmaz Dursun Alper
Published: November 2022

Autism spectrum disorder (ASD) is a pervasive developmental disorder with limited social and communication skills, and limited and repetitive movements. Motor skills in these individuals may differ compared to their peers. It is known that it creates a special risk group because it increases the risk of heart diseases, diabetes and obesity. It is thought that physical activity will also be effective on individuals with autism in terms of proving that it is an effective tool in reducing these risks in individuals with normal development. Despite the partial success of standard treatment methods for ASD, there has been an increase in recent years that physical activity can have positive effects on children with autism. According to the studies examined, it is stated that physical activity reduces the maladaptive behavior patterns of people with ASD as well as physical development. In the studies reviewed in the literature, it has been determined that participation in physical activity in children with autism reduces stereotypic behaviors. In addition, it has been found that physical activity has positive effects on communication skills, sensory skills and academic skills of children with communication autism. In this review, the effects of physical activity interventions on individuals with ASD are discussed.
A Importância do farmacêutico clínico nos tempos de pandemia correlacionado as interações medicamentosas em Açailândia-MA
Authors: Sousa Nayranna Chrystina Sobrinho Costa de , Sousa Vinycius Manoel Sobrinho Costa de , Lima Junior Francisco Alves , Queiroz Patrícia dos Santos Silva , Lima Karla Vanessa Morais , Carvalho Flávio Silva de , Fernandes Enderson Sousa , Gomes Benedita Maryjose Gleyk , Gonçalves Caroline Amélia , Machado Antonio Silva
Published: November 2022

Tendo em vista que a pandemia por COVID-19 trouxe um grande problema na saúde mundial, ocasionou maior atuação de profissionais da saúde, inclusive farmacêutico pela alta demanda na prestação de serviços em saúde de forma individualizada e coletiva na farmacoterapia e educação em saúde. O SARS-CoV-2 é contagioso, manifestando-se de forma aguda grave caracterizando-se como síndrome respiratória aguda grave (SDRA), onde os sintomas são semelhantes a outras infecções virais, tendo variabilidade de transmissibilidade de indivíduo para indivíduo. Pesquisa-se sobre as interações medicamentosas durante a pandemia em Açailândia-MA, a fim de apontar a importância do Farmacêutico clínico durante o cenário pandêmico. Para tanto, é necessário analisar as interações medicamentosas recorrentes ao tratamento de COVID-19 e compilar o problema da automedicação durante a pandemia. Realiza-se uma pesquisa de campo por meio de receitas médicas. Diante disso, verifica-se que os resultados apresentados de 248 receitas médicas resultam em antimicrobianos (n=280), antiparasitários (n=138) e vitaminas (n=128) prescritos, observando as interações destes pela gravidade destacando a moderada em 96,3% em maior percentual. O que impõe a constatação é que o farmacêutico se torna o profissional imprescindível na qualidade de vida do paciente podendo otimizar o tratamento farmacológico e melhoria em saúde e adesão a farmacoterapia.
Evidências sobre a percepção e apoio paterno na amamentação
Authors: Oliveira Brian Araujo , Rocha Silvana Santiago , Nascimento Marcelo Victor Freitas , Dantas Amanda Lúcia Barreto , Vaz Bruna Araújo , Ramos Júlia Melo , Santos Laryssa Maria Ferreira dos , Homem Dayla Soeiro , Pereira Bruna Rívia Ferreira da Silva , Araújo Vitória Gabriele Barros de , Silva Júnior Paulo Gonçalves Lima , Silva Aline Alves da , Souza Ana Paula de Carvalho
Published: November 2022

O presente estudo objetiva analisar as evidências na literatura acerca da percepção e apoio paterno na amamentação; analisar fatores desencadeadores do desmame precoce relacionados à falta da participação paterna ao processo de aleitamento; a participação paterna no aleitamento materno e seus benefícios à mãe e bebê. Trata-se de uma revisão integrativa da literatura realizada nas bases de dados da Biblioteca Virtual de Saúde, Lilacs, Scielo, Medline e BDENF que incluiu publicações de 2017 a 2021. A amostra final foi constituída por 13 artigos, sendo refinados a partir de uma leitura exaustiva. Conclui-se que a participação ativa do pai no processo de amamentação é de extrema relevância, pois a mulher se torna suscetível à interrupção do aleitamento diante das dificuldades. A literatura pesquisada evidencia que muitos homens têm a percepção de que o seu apoio é fundamental para a continuidade da amamentação, porém o desconhecimento de como ajudar a mulher e participar desse processo é uma barreira que promove sua ausência, além da cultura que afirma que amamentar é um ato exclusivo da mulher. Desta forma, esses homens devem ser incluídos ao pré-natal para que possam ser ensinados a como cuidar da criança e serem incentivadores do aleitamento materno.
Panorama da infecção pelo HSV: uma revisão integrativa da literatura
Authors: Souza Isaias Sena Moraes de , Pereira Laura Maria de Araújo , Guedes Talyta Valeria Siqueira do Monte , Araújo Janemary Malheiro de , Costa Ana Lucila dos Santos , Pereira Rafaell Batista , Araújo Hallysson Douglas Andrade de , Nogueira Filho Ricardo Marques , Nascimento Júnior José Adelson Alves do , Maciel Nadine Gabryella Pontes , Silva Júnior José Guedes da
Published: November 2022

O presente trabalho teve por objetivo a realização de uma revisão integrativa da literatura a respeito da infecção pelos vírus causadores do herpes (HSV-1 e HSV-2), visando a elucidação de aspectos clínicos e complicações associadas à infecção, bem como a apresentação de dados epidemiológicos, formas de transmissão, características do patógeno e o cenário atual sobre o desenvolvimento de imunobiológicos, apresentado de uma maneira superficial. Além disso, há a apresentação de dados da enfermidade no Brasil entre o mês de janeiro de 2019 a abril de 2020 (em um momento pré-pandemia do SARS-CoV-2) e entre janeiro de 2021 a abril de 2022 (em um momento pós desenvolvimento de vacinas para o SARS-CoV-2). As bases de dados internacionais PubMed, SciELO e LILACS, foram utilizadas durante as buscas, bem como informações provenientes da Organização Mundial de Saúde, foram selecionadas. Dessa forma, houve a seleção de 30 artigos científicos para compor a base bibliográfica da vigente revisão, segundo os critérios de inclusão e exclusão pré-estabelecidos.
Relato de caso: Esclerose Múltipla após infecção por COVID-19
Authors: Pastorio Daiane Maria , Loth Eduardo Alexandre
Published: November 2022

Em dezembro de 2019, uma nova doença por Coronavírus chamada COVID-19, eclodiu na China se expandindo por todo o mundo evoluindo para uma pandemia preocupante. De acordo com o Ministério da Saúde até 31 de maio de 2022 ocorreram 30.977.661 de casos de COVID-19 no Brasil e aproximadamente 666.516 mortes foram registradas. A pandemia tem causado consequências importantes em todos os setores como altas taxas de desemprego, economia, educação, e saúde trazendo um agravo crônico subfinanciamento do Sistema Único de Saúde (SUS), gerando uma crise sanitária inédita. A COVID-19 é uma doença causada pelo SARS-CoV-2 (coronavírus 2 da síndrome respiratória aguda grave). Os sintomas da infecção por SARS-CoV-2 podem incluir febre, tosse, perda de olfato e paladar, dor de garganta, cefaléia, diarréia e fadiga, podendo variar de pessoa para pessoa, porém, a maioria dos infectados podem permanecer assintomáticos ou desenvolverem sintomas leves a moderados, sem necessidade de intervenção hospitalar. No entanto, alguns indivíduos podem progredir de pneumonia grave para insuficiência respiratória, Choque séptico e possivelmente morte. Neste estudo, relata-se um caso de uma mulher de 42 anos, brasileira, com diagnóstico de Esclerose Múltipla (EM) após infecção por COVID-19, alertando para associação da EM pós COVID-19. Embora o mecanismo da relação entre a EM e COVID-19 não seja estudado aqui, o estudo alerta para está possibilidade e a importância de investigar sintomas como parestesias, fraquezas musculares e sintomas visuais após infecção por SARS-CoV-2.
Estado nutricional de idosas praticantes e não praticantes de atividade física associado à situação físico-funcional
Authors: Macedo Milena Duarte de , Gonzaga Jozilma de Medeiros , Olinda Ricardo Alves de , Menezes Tarciana Nobre de
Published: November 2022

O envelhecimento populacional merece atenção devido às mudanças biopsicossociais que acontecem com o idoso. Dentre as alterações, o estado nutricional ganha destaque, pois seus distúrbios predispõem o idoso ao aparecimento de doenças. O presente estudo tem como objetivo avaliar o estado nutricional associado à situação físico-funcional em idosas praticantes de atividade física (PAF) e não praticantes de atividade física (NPAF). Trata-se de um estudo transversal, com abordagem quantitativa, realizado com idosas do programa Universidade Aberta no Tempo Livre da Universidade Estadual da Paraíba e idosas de grupos de convivência. As variáveis estudadas foram: índice de massa corporal (IMC), força de preensão manual, ganho e perda de peso, atividades básicas de vida diária, número de quedas, circunferência da cintura (CC) e circunferência da panturrilha (CP). Na análise estatística foi ajustado um modelo de regressão Gamma. Adotou-se um nível de significância de 5%. Foram avaliadas 35 idosas PAF e 36 idosas NPAF. O fator associado ao IMC nas idosas PAF foi a CC. Entre as idosas NPAF houve associação do IMC com a CC e com a CP. Através do conhecimento das variáveis que influenciam o IMC de idosos PAF e NAPF, é possível criar estratégias de saúde de acordo com a necessidade de cada grupo.
Gestão de conformidade (compliance): reflexões sobre o impacto na estrutura e desempenho da governança
Authors: Vasconcelos Yumara Lúcia , Soares Amanda Paulino
Published: November 2022

A elaboração deste artigo, apresenta os resultados de uma pesquisa bibliográfica cujo objetivo geral foi apresentar reflexões sobre o impacto dos programas de compliance e gestão de conformidade sobre a estrutura e desempenho da governança, mapeando os fatores de sucesso. Selecionadas as obras que constituíram as fontes revisadas, realizou-se a análise de conteúdo orientada pelas seguintes categorias temáticas estruturantes:  alicerces da governança corporativa, compliance e interconexão; aspectos estruturantes da gestão de conformidade (dimensão instrumental); mitigação de risco; interface entre os instrumentos gerenciais e o aparato de controle interno. Resultou deste apanhamento a constatação, em uma perspectiva instrumental, da relação de continência entre os conceitos governança corporativa, gestão de conformidade e os Programa de compliance e integridade. Documentos diretivos, políticas, controles internos, processos procedimentos e protocolos são produtos humanos. A aderência às diretivas organizacionais, mais que respostas condicionadas, precisam produzir adesão consciente e espontânea. Quanto maior a for a adesão e engajamento organizacional aos comandos dirigentes, mais efetivos serão os controles internos, menor será o número de ocorrências de comportamentos desviantes, ou mesmo, de ilícitos. Pelos argumentos apresentados, restou evidente a importância desses Programas, ou em sentido expandido, da gestão de conformidade, para a instituição de um ambiente de governança responsivo, eficiente, eficaz e socialmente responsável.
A relação entre a doença de Chagas e a hipertensão arterial sistêmica: revisão integrativa
Authors: Schramm Neto Fernando Antônio Ramos , Faria Carolina Dourado de , Machado Yuri de Jesus , Oliveira Lahyse de Oliveira e , Medeiros Rafaella Cazé de , Carneiro Mauricio Mota Nogueira , Oliveira Rodrigo Matos Marques de , Castro Pedro Cavalcante , Diniz Jéssika Pereira Marques , Silva Roberto de Barros
Published: November 2022

A doença de Chagas é uma infecção causada pelo protozoário Trypanosoma cruzi. Essa patologia apresenta curso clínico bifásico, dividido em agudo e crônico, no qual o segundo é responsável por 10 a 30% das complicações cardíacas associadas, sendo que dentre as principais formas de comprometimento cardiovascular, vale destacar a ocorrência da Hipertensão Arterial Sistêmica (HAS). Portanto, o objetivo deste estudo foi revisar a literatura acerca das principais características que envolvem a relação entre a doença de Chagas e a HAS. Para isso, foi realizada uma busca por estudos nas seguintes bases de dados bibliográficos: PubMed, STM (Science Translational Medicine) e SciELO (Scientific Eletronic Library Online), durante o período de setembro a outubro de 2022. Dentre os resultados apresentados, do total de 195 estudos encontrados nas bases de dados citadas, apenas 30 foram usados como fontes para esta revisão, sendo 7 artigos originais e 23 de revisão. Os dados referentes a cada um dos trabalhos estão expostos no Quadro 1, elaborado pelos autores. Dessa forma, embora a literatura atual tenha poucos estudos relacionados a esta temática, duas hipóteses puderam ser levantadas: a primeira classifica a HAS um fator de risco para a doença de Chagas, e a segunda a considera para pacientes chagásicos que possuem predisposição para doenças cardiovasculares. No entanto, ambas a denominam como complicação da tripanossomíase.
Perbandingan antara GAAP Indonesia dan GAAP Italia
Authors: Christian Natalis , Angelica Serly , Tanwijaya Rachel
Published: November 2022

Indonesia and Italy have been adopting IFRS in their national accounting standards. However, Indonesia’s GAAP is different from Italy’s GAAP. Hence, financial information users must be educated and understand both countries’ GAAP to interpret the financial report. The purpose of the research is to compare Indonesia’s GAAP and Italy’s GAAP. The research method uses descriptive qualitative analysis. The source of data is based on non-numeric secondary data. The research result shows eight factors that affect accounting development in Italy. There are also differences between Indonesia’s GAAP and Italy’s GAAP. Those differences are related to financial reports presentation, interests, dividends, goodwill, consolidated financial statements, and inventories.

 

Keywords: Accounting standard, OIC, SAK, Italy, Indonesia

 

Abstrak

Indonesia dan Italia telah menerapkan IFRS pada standar akuntansi nasional negara masing-masing. Akan tetapi, GAAP Indonesia dengan GAAP Italia memiliki perbedaan dalam metode pencatatan akuntansi. Oleh sebab itu, untuk dapat memahami laporan keuangan yang disusun berdasarkan GAAP masing-masing negara, pengguna laporan keuangan perlu memiliki pemahaman dan menguasai pencatatan GAAP kedua negara tersebut. Tujuan dari penelitian ini adalah melakukan perbandingan antara GAAP Indonesia dan GAAP Italia. Metode penelitian yang diterapkan merupakan metode deskriptif kualitatif. Data penelitian yang digunakan bersifat data sekunder non numerik. Hasil dari penelitian ini menjukkan adanya 8 faktor yang memengaruhi perkembangan akuntansi di Italia. Selain itu, terdapat perbedaaan antara standar akuntansi Indonesia dan standar akuntansi Italia. Perbedaan tersebut terdiri dari segi pelaporan keuangan, bunga, dividen, goodwill, laporan keuangan konsolidasi dan persediaan.

 

Kata kunci: Standar Akuntansi, OIC, SAK, Italia, Indonesia
Pengaruh Bi Rate, IHK, Dan JUB (M2) Terhadap NAB Reksadana Pada Masa Pandemi Covid-19 di Indonesia
Authors: Nurjannah Alfira , Hartini Titin , Azwari Peny Cahaya
Published: November 2022

The development of Mutual Funds is moving in a positive direction, with Net Asset Values ​​that continue to increase even during the Covid-19 pandemic. Several studies state that factors can affect the Net Asset Value of Mutual Funds, including the BI Rate, Consumer Price Index (CPI), and Money Supply (JUB). The methodology used in this study is quantitative in the form of data analysis techniques that were tested statistically using the classical assumption test and multiple linear regression. The data used is with a monthly time series from March 2020 to March 2022, which is the era of the COVID-19 pandemic in Indonesia. The data is processed using Eviews-12. Based on the research results, the Net Asset Value (NAV) of Mutual Funds is simultaneously influenced by the BI Rate, CPI, and JUB (M2). However, partially NAV of Mutual Funds is negatively and significantly affected by the BI Rate. In contrast, CPI affects NAV of Mutual Funds negatively but not significantly, then JUB affects NAV of Mutual Funds positively but not significantly.

 

Keywords: BI Rate, Consumer Price Index, Money Supply, Net Asset Value

 

Abstrak

Perkembangan Reksadana bergerak kearah positif dengan Nilai Aktiva Bersih yang terus meningkat meskipun dalam masa pandemi Covid-19. Beberapa penelitian menyatakan bahwa terdapat faktor-faktor yang dapat mempengaruhi Nilai Aktiva Bersih Reksadana diantaranya yaitu BI Rate, Indeks Harga Konsumen(IHK), dan Jumlah Uang Beredar(JUB). Metodologi yang digunakan pada penelitian ini adalah kuantitatif berupa teknik analisa data yang diuji statistik menggunakan uji asumsi klasik serta regresi linear berganda. Data yang digunakan adalah data dengan deret waktu perbulan, mulai bulan Maret 2020 hingga Maret 2022 yang merupakan era pandemic covid-19 di Indonesia data tersebut diolah menggunakan Eviews-12. Berdasarkan hasil penelitian, Nilai Aktiva Bersih (NAB) Reksadana secara simultan dipengaruhi oleh BI Rate, IHK, dan JUB (M2). Namun dalam secara parsial NAB Reksadana dipengaruhi secara negatif dan signifikan oleh BI Rate, sedangkan IHK mempengaruhi NAB Reksadana secara negatif tetapi tidak signifikan, kemudian JUB mempengaruhi NAB Reksadana secara positif namun tidak signifikan.

 

Kata Kunci: BI Rate, Indeks Harga Konsumen, Jumlah Uang Beredar, Nilai Aktiva Bersih
Distinct profiles of bilingual reference production
Authors: Vogelzang Margreet , Torregrossa Jacopo
Published: November 2022

Reference production is a complex task that requires keeping track of discourse referents and selecting discourse-appropriate referring expressions (REs). Whether an RE is appropriate depends on the status of the referent in discourse. The use of REs by bilingual children is subject to individual variation and it has been suggested that distinct cognitive profiles may underly reference production. Although first attempts at examining correlations between reference production and cognitive abilities have been made, as of yet no clear profiles of bilingual reference production have been identified. In this project, we aim to identify distinct profiles of bilingual reference and link these to children’s language background and cognitive abilities.To this end, we tested 37 Italian-Greek near-balanced bilingual children (Mage=9;4) from Athens (Greece), who have Italian as their heritage language. The children performed a narrative retelling in both Greek and Italian, as well as vocabulary and cognitive tasks.
Research on skeletal muscle impact injury using a new rat model from a bioimpact machine
Authors: Liu Jun , Liao Zhikang , Wang Jingkun , Xiang Hongyi , Zhu Xiyan , Che Xingping , Tang Yuqian , Xie Jingru , Mao Chengyi , Zhao Hui , Xiong Yan
Published: November 2022

Introduction: Skeletal muscle impact injury occurs frequently during sports, falls, and road traffic accidents. From the reported studies on skeletal muscle injury, it is difficult to determine the injury parameters. Therefore, we developed a new model of gastrocnemius impact injury in rats with a bioimpact machine, with which the experimental operation could be conducted in feasibility from the recorded parameters. Through this novel model, we study the skeletal muscle impact injury mechanisms by combining temporal and spatial variation.

Methods: The gastrocnemius of anesthetized rats was injured by a small pneumatic-driven bioimpact machine; the moving speed and impact force were determined, and the whole impact process was captured by a high-speed camera. We observed the general condition of rats and measured the changes in injured calf circumference, evaluating calf injuries using MRI, gait analysis system, and pathology at different times after the injury.

Results: The gastrocnemius was injured at an impact speed of 6.63 m/s ± 0.25 m/s and a peak force of 1,556.80 N ± 110.79 N. The gait analysis system showed that the footprint area of the RH limb decreased significantly on the first day and then increased. The calf circumference of the injured limb increased rapidly on the first day post-injury and then decreased in the next few days. MRI showed edema of subcutaneous and gastrocnemius on the first day, and the area of edema decreased over the following days. HE staining showed edema of cells, extensive hyperemia of blood vessels, and infiltration of inflammatory cells on the first day. Cell edema was alleviated day by day, but inflammatory cell infiltration was the most on the third day. TEM showed that the sarcoplasmic reticulum was dilated on the first day, the mitochondrial vacuolation was obvious on the second day, and the glycogen deposition was prominent on the fifth day.

Conclusion: In our experiment, we developed a new and effective experimental animal model that was feasible to operate; the injured area of the gastrocnemius began to show “map-like” changes in the light microscope on the third day. Meanwhile, the gastrocnemius showed a trend of “edema-mitochondrial vacuolation-inflammatory cell aggregation” after impact injury.
Machine learning outperforms traditional logistic regression and offers new possibilities for cardiovascular risk prediction: A study involving 143,043 Chinese patients with hypertension
Authors: Xi Yang , Wang Hongyi , Sun Ningling
Published: November 2022

Introduction

Identifying people at risk of cardiovascular diseases (CVD) is a cornerstone of preventive cardiology. We developed machine learning (ML) algorithms and investigated their performance in predicting patients’ current CVD risk (coronary heart disease and stroke in this study).

Materials and methods

We compared traditional logistic regression (LR) with five ML algorithms LR with Elastic-Net, Random Forest (RF), XGBoost (XGB), Support Vector Machine, Deep Learning, and an Ensemble model averaging predictions from RF, XGB, and Deep Learning for CVD risk prediction using pre-existing patient-level data from a multi-center, cross-sectional study (the Microalbuminuria Screening in Hypertensive Patients Project initiated by the China International Exchange and Promotive Association for Medical and Healthcare) that enrolled 143,043 patients with hypertension from 600 tertiary, secondary, or community hospitals. Each of the five ML algorithms incorporated 18 variables, such as demographics, examinations, comorbidities, and treatment regimens, and were trained and evaluated using 5-fold cross-validation. Predictive accuracy was assessed by the area under the receiver operating curve (AUROC).

Results

Patients’ mean age was 62 ± 12 years and 57% were men. Advanced ML algorithms outperformed the traditional LR model. Particularly, the Ensemble model had superior discrimination with an AUROC of 0.760 than LR (AUC = 0.737) and other tested models.

Conclusion

We establishes an Ensemble model that shows better performance in predicting patients’ current CVD risk using routine information compared to the traditional LR model. ML can help physicians design follow-up plans with more accurate results, offering new possibilities for short-term risk prediction and early detection. Further, ML models can be trained with longitudinal data and used to predict long-term CVD risks, thereby informing CVD prevention.
Clinical significance of right ventricular–pulmonary arterial coupling in patients with tricuspid regurgitation before closure of atrial septal defect
Authors: Lee Seon Hwa , Shin Yu Rim , Kim Dae-Young , Seo Jiwon , Cho Iksung , Lee Sak , Kim Jung Sun , Hong Geu-Ru , Ha Jong-Won , Shim Chi Young
Published: November 2022

Background

Functional tricuspid regurgitation (TR) usually decreases after atrial septal defect (ASD) closure; however, it may persist and cause heart failure that requires treatment. We aimed to investigate clinical and echocardiographic factors predicting persistent TR after ASD closure.

Methods

Among 348 adults who underwent isolated ASD closure between January 2010 and September 2020, 91 (26.1%) patients with significant TR (at least moderate degree) before ASD closure were included. Persistent TR was defined as significant TR on echocardiography at 6 months to 1 year after ASD correction. We comprehensively analyzed the echocardiogram before ASD closure, including speckle-tracking imaging. Right ventricular (RV)–pulmonary arterial (PA) (RV–PA) coupling was assessed by the ratio of RV global longitudinal strain (RV GLS) and tricuspid annular S' velocity to PA systolic pressure (PASP).

Results

Persistent TR was observed in 22 (24.2%) patients. Patients with persistent TR were significantly older and had larger TR jet areas and lower RV–PA coupling parameters than those without persistent TR. On multivariable regression, persistent TR was independently associated with age [odds ratio (OR) 1.07, 95% confidence interval (CI) 1.01–1.14, p = 0.030) and |RV GLS|/PASP (OR 0.001, 95% CI 0.00–0.017, p = 0.012). ROC curves analysis showed that |RV GLS|/PASP's best cut-off for persistent TR was 0.46 (cut-off 0.46, the area under the curve 0.789, p < 0.001).

Conclusion

Persistent TR after ASD closure is not rare. Old age and RV–PA uncoupling could be associated with persistent TR after ASD closure. In older patients with abnormal RV–PA coupling, careful evaluation and concomitant or subsequent TR intervention may be considered.
Risk of hypovolemia associated with sodium–glucose cotransporter-2 inhibitors treatment: A meta-analysis of randomized controlled trials
Authors: Rong Xi , Zhu Yawen , Wen Bo , Liu Kai , Li Xinran , Gou Qiling , Chen Xiaoping
Published: November 2022

Aim of the review

To assess the risk of hypovolemia for sodium–glucose cotransporter-2 (SGLT2) inhibitors treatment.

Method

A systematic literature retrieval was performed in PubMed, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science, and Scopus from inception up to 4 October 2022, Data for study characteristics and outcomes of interest were extracted from each eligible study. Risk ratios (RRs) with a 95% confidence interval (CI) for hypovolemia were calculated using a random-effect model.

Results

A total of 57 studies (n = 68,622) were included in our meta-analysis, with a result of 1,972 hypovolemia incidents (1,142 in the SGLT2 inhibitors group and 830 in the control group). The pooled RR was 1.12 (95% CI: 1.02–1.22). It is evident that receiving SGLT2 inhibitors increased the risk of hypovolemia. When stratified by category of SGLT2 inhibitors the result was consistent; when the subgroup was analyzed by age, the pooled RR was 1.07 (95% CI: 0.94–1.23) in patients aged ≥65 years and 1.14 (95% CI: 1.02–1.28) in those aged <65 years. When comparing the baseline estimated glomerular filtration rate (eGFR) of less than or equal to 60 mL/min/1.73 m2 with a baseline eGFR greater than 60 mL/min/1.73 m2, the pooled RR was 1.21, (95% CI: 1.00–1.46) and 1.08, (95%CI: 0.98–1.20), respectively.

Conclusion

Our meta-analysis has demonstrated that SGLT2 inhibitors increased the risk of hypovolemia in patients with Type 2 Diabetes Mellitus (T2DM). It is necessary to pay attention to the risk of hypovolemia associated with SGLT2 inhibitors, especially in older individuals and those with moderate renal impairment.

Systematic review registration

[https://www.crd.york.ac.uk/prospero/], identifier [CRD42020156254].