bluuebunny/crossref_metadata_2025 huggingface dataset:
Zonal Asymmetry of the Stratopause in the 2019/2020 Arctic Winter
Authors: Shi Yu , Evtushevsky Oleksandr , Milinevsky Gennadi , Klekociuk Andrew , Han Wei , Ivaniha Oksana , Andrienko Yulia , Shulga Valery , Zhang Chenning
Published: February 2022

The aim of this work is to study the zonally asymmetric stratopause that occurred in the Arctic winter of 2019/2020, when the polar vortex was particularly strong and there was no sudden stratospheric warming. Aura Microwave Limb Sounder temperature data were used to analyze the evolution of the stratopause with a particular focus on its zonally asymmetric wave 1 pattern. There was a rapid descent of the stratopause height below 50 km in the anticyclone region in mid-December 2019. The descended stratopause persisted until mid-January 2020 and was accompanied by a slow descent of the higher stratopause in the vortex region. The results show that the stratopause in this event was inclined and lowered from the mesosphere in the polar vortex to the stratosphere in the anticyclone. It was found that the vertical amplification of wave 1 between 50 km and 60 km closely coincides in time with the rapid stratopause descent in the anticyclone. Overall, the behavior contrasts with the situation during sudden stratospheric warmings when the stratopause reforms at higher altitudes following wave amplification events. We link the mechanism responsible for coupling between the vertical wave 1 amplification and this form of zonally asymmetric stratopause descent to the unusual disruption of the quasi-biennial oscillation that occurred in late 2019.
Orientação sexual e seus efeitos no mercado de trabalho: um estudo com base na técnica de revisão sistemática
Authors: Suliano Daniel , Irffi Guilherme , Rêgo de Sá Barreto Ana Beatriz
Published: February 2022

Ao fazer uso da técnica de revisão sistemática, este trabalho apresenta dois objetivos. Em primeiro lugar, procurou-se identificar por meio da literatura especializada diferentes formas de classificação da orientação sexual no âmbito do mercado de trabalho. Tendo em vista o segundo objetivo, analisou-se o mercado de trabalho como um canal que gera distribuição desigual de renda mediante mecanismos discriminatórios a partir dos diferenciais de rendimentos com base na orientação sexual. A fonte de dados utilizada foi a plataforma Periódicos Capes. Entre os resultados, quatro formas de identificação da orientação sexual foram observadas, tendo as uniões consensuais (coabitação) o maior número de estudos, seguidas da autodeclaração, comportamento e militância. Adicionalmente, pode-se destacar a penalidade salarial sofrida por homens gays vis-à-vis as suas contrapartes sexuais, prêmio salarial para lésbicas, com relação às mulheres heterossexuais, e desvantagens dos homossexuais na inserção do mercado de trabalho em simulações na taxa de convite para entrevista, revelando, assim, indícios de discriminação logo na etapa inicial de contratação. Finalmente, é ressaltado que, mesmo na presença de legislações que protejam minorias sexuais, até em países mais liberais e tolerantes, o ambiente profissional não está completamente alinhado à produtividade do trabalhador.
Correlation and Regression Between Age and Body Weight on Semen Quality of Limousin Bulls in Artificial Insemination Center, Lembang, West Java
Authors: Royan Muhamad Allabus , Dakhlan Akhmad , Hartono Madi , Suharyati Sri
Published: February 2022

This research aimed to determine the correlation and to find the best regression model for predicting semen quality (semen volume, individual motility, and sperm concentration) based on age and body weight in Limousin bulls. This research was conducted in December 2019 in Artificial Insemination Center, Lembang, West Java. The method used was a survey with census data collection, namely all Limousin bulls with semen collected were used in this study. The data were analyzed for correlation and simple and multiple regression using R program. The results showed that the average of age, body weight, semen volume, individual motility and sperm concentration were 58.36 ± 40.19 months, 807.12 ± 91.59 kg, 5.86 ± 1.31 ml, 67.59 ± 4.11%, and 1006.23 ± 145.28 million/ml, respectively. Age with semen volume, body weight with semen volume, and combination of age and body weight with semen volume, had a medium positive correlation (P<0.05), with a correlation coefficient of 0.52, 0.58 and 0.58, respectively. The regression model with the highest coeficient of determination value (R2) was between body weight and semen volume with regression equation of Ŷ = -0.8129 + 0.008269X and of R2 = 0.34. In conclusion, semen volume of Limousin bull could be estimated using their age and body weight, while individual motility and sperm concentration might not be able to be estimated using their age and body weight.
Performance and Quality of Broiler Meat During Transportation with Various Durations and ZnSO4 level
Authors: Widyasari Dhini Nova , Ulupi Niken , Afnan Rudi , Mutia Rita , Lase Jonathan Anugrah
Published: February 2022

Heat stress in the poor transportation systems will impact the oxidative stress, affecting the quality of chicken meat. The decrease in heat stress levels can be trigerred through antioxidants, one of which is ZnSO4 antioxidants, before cutting. This study aimed to examine the reduction of post-transport stress on the performance of chickens, carcasses, and the physical and chemical qualities of broiler meat treated with ZnSO4. The total broiler chickens transported were 324 roosters aged 4 weeks (with 3 replicates each). All of the transported chickens were treated with ZnSO4 at doses of 0, 80, and 160 ppm for 7 days. Next, the chickens were transported with a travel time of 1, 2, and 3 hours. The breast meats were taken (filet) to be used as research samples. A factorial randomized block design was used as the research design and the data were analyzed using ANOVA (analysis of variance). The results showed that there was no correlation between travel time and the ZnSO4 levels on broiler chicken performance (weight and carcass loss) and physicochemical quality of broiler meat (pH value, percentage of water lost, aw, cooking loss, glycogen content and MDA). Longer travel time significantly reduced live weight, carcass percentage, pH value, glycogen content, while increasing the MDA levels. The addition of ZnSO4 can significantly increase the pH value of breast meat, maintain high glycogen levels, increase carcass percentage, and inhibit MDA formation.
Nutrient Intake, Feed Digestibility, and Growth Performance of Thin-Tailed Sheep Fed Complete Feed Containing Fermented Sargassum sp.
Authors: Budi Dian Setya , Astuti Andriyani , Utomo Ristianto
Published: February 2022

The aim of this research was to identify the effect of feeding fermented Sargassum sp. as complete feed ingredient up to 20% of total feed on nutrient consumption and digestibility, and growth performance of thin-tailed sheep. Twelve female thin-tailed sheep aged 6 to 8 months with an average initial body weight of 14.13 ± 2.08 kg were divided into three groups. The treatments were control without fermented Sargassum sp. (S0), 10% fermented Sargassum sp. (S1), and 20% fermented Sargassum sp. (S2). Complete feed was formulated by isoprotein and isoenergy formulation, containing 16% of crude protein and 61% of total digestible nutrients. Complete feed was given at 3.5% of body weight (% dry matter) and drinking water was provided ad libitum. This research was done in 6 weeks with 14 days adaptation period and seven days of collection period. Growth performance was measured for 4 weeks after the adaptation period. The variables observed were dry matter (DM), organic matter (OM), crude protein (CP), ether extract (EE), crude fiber (CF), nitrogen-free extract (NFE), and total digestible nutrients (TDN) consumption. The data obtained were subjected to one-way ANOVA (analysis of variance) and the difference existed (P value <0.05) between means were analyzed with Duncan’s multiple range test. The results showed that there was no significant effect of feeding fermented Sargassum sp. on nutrient intake, and digestibility of nutrients (P>0.05), however, S0 treatment appeared to have CP, CF, and EE intake, as well as digestibility of DM, CP, CF, and NFE higher than S1 and S2 treatment. The results showed that there was no significant effect of feeding fermented Sargassum sp. on nutrient intake, digested and digestibility of nutrient, absolute and relative weight gain as well as feed conversion.
Determination of Morphological Characteristics in Kuantan Cattle using Multivariate Analysis
Authors: Misrianti Restu , Mainidar Jessy , Asharudin Hasrul Bani , Dedi Yureni Sahril , Ali Arsyadi , Wijaya Sony Hartono , Sumantri Cece , Jakaria Jakaria
Published: February 2022

The objective of this research was to characterized morphology and estimated genetic distance between intra population of Kuantan cattle. A Total of 213 cattle (44 male and 169 female with age ranging from 2-3 years) were used in this study and collected from extensive ranging systems in Three sub-population (Cerenti, Inuman, and Kuantan Hilir regions) Kuantan Singingi Regency, Riau Province. Five variables were measured that is Body Length (BL)(cm), Wither Height (WH)(cm), Hip Height (HH)(cm), Chest Girth (CG)(cm), and Chest Depth (CD)(cm). Data obtained were descriptive analysis, Principal Components Analysis (PCA) and Hierarchichal Clustering Analysis (HCA)  using XLSTAT program. All variables of body measurement in the Kuantan Hilir region were higher than Cerenti dan Inuman, Kuantan Singingi Regency. The first factor in PCA described body measurement contributed 32.77%, and the second factor described body shape contribute 25.83% of total variability. The dendrogram showed there is Three clusters of Kuantan Cattle based on this research.
Fermentation Technology using Phanerochaete chrysosporium to Improve the Quality of Nutrition of Pod Coffe as Ruminant Feed
Authors: Yakin Engkus Ainul , Mulyono Ali Mursyid Wahyu , Sariri Ahimsa Kandi
Published: February 2022

This study was carried out to assess the effect of solid state fermentation by using P. chrysosporium on nutrient composition of pod coffee and to evaluate its potency as ruminant feed in vitro. The in vitro experiment was conducted to determine fermentability of treated pod coffee. Fermented pod coffee by P. chrysosporium 0, 1, 2, 3, 4 % (R0 to R4). Pod coffee were air dried to moisture content of 10%-15% and then fermented with P. chrysosporium. The solid state fermentation trials were carried out on a laboratory scale. The result of this studi were fermentation of pod coffee by P. chrysosporium increased protein from 10.36% to 12.64%, and cellulose from 18.51% to 23.80%, and decreased lignin, from 64.42% to 44.04%, tannin from 1.02% to 0.18%, and caffeine from 1.39% to 0.20%. There were no differences in ruminal pH and N-ammonia production but volatile fatty acid production and dry matter digestibility decreased as the fermented of pod coffee level increased. The ruminal protozoa population in fermented of pod coffee diets was lower than the control diets (P<0.05). Conclusion in this study that fermented of pod coffee with P. chrysosporium can increase protein and cellulose concentration, but decrease lignin, tannin, and caffeine concentration.
Implementation Strategies to Promote Measurement-based Care in Schools: Evidence from Mental Health Experts Across the United States
Authors: Connors Elizabeth H , Lyon Aaron R , Garcia Kaylyn , Sichel Corianna , Hoover Sharon , Weist Mark D , Tebes Jacob
Published: February 2022

Background: Despite an established, comprehensive taxonomy of implementation strategies, minimal guidance exists for how to select and adapt strategies to specific services and contexts. We employed a replicable method to identify the most feasible and important implementation strategies to increase mental health providers’ use of measurement-based care (MBC) in schools. MBC is the routine use of patient-reported progress measures throughout treatment to inform patient-centered, data-driven treatment adjustments. Methods: A national sample of 52 school mental health providers and researchers completed two rounds of modified Delphi surveys to rate the relevance, importance, and feasibility of 33 implementation strategies identified for school settings. Strategies were reduced and definitions refined using a multimethod approach. Final importance and feasibility ratings were plotted on “go-zone” graphs and compared across providers and researchers to identify top-rated strategies. Results: The initial 33 strategies were rated as “relevant” or “relevant with changes” to MBC in schools. Importance and feasibility ratings were high overall for both survey rounds; on a scale of 1 to 5, importance ratings (3.61 - 4.48) were higher than feasibility ratings (2.55 – 4.06) on average. Survey 1 responses resulted in a reduced, refined set of 21 strategies, and six were rated most important and feasible on Survey 2: 1) assess for readiness and identify barriers and facilitators; 2) identify and prepare champions; 3) develop a usable implementation plan; 4) offer a provider-informed menu of free, brief measures; 5) develop and provide access to training materials; and 6) make implementation easier by removing burdensome documentation tasks. Provider and researcher ratings were not significantly different, with a few exceptions: providers reported higher feasibility and importance of removing burdensome paperwork than researchers, and providers reported higher feasibility of train-the trainer approaches than researchers; researchers reported higher importance of monitoring fidelity than providers. Conclusions: The education sector is the most common setting for child and adolescent mental health service delivery in the United States. Effective MBC implementation in schools has the potential to elevate the quality of care received by many children, adolescents, and their families. This empirically-derived, targeted list of six implementation strategies offers potential efficiencies for future testing of MBC implementation in schools.
EREG increases stemness associated genes expression and promotes Chemoresistance of non-small cell lung cancer via ERK signaling
Authors: Xu Wei , Zhang Yujia , Qiu Fengjun , Ye Tingjie , Lee Sau Har , Xu Jiatuo , Jia Lingyan , Zeng Rui , Wang Xiaoling , Hu Xudong , Yan Xiaofeng , Li Hua , Lu Yanlin , Jiang Rilei
Published: February 2022

Background: Chemotherapy is the preferred approach for treatment of advanced non-small cell lung cancer (NSCLC), but it often resulted in acquired resistance, which led to the failure of treatment. Therefore, it is necessary to identify and remove the resistant cancer cells in the tumors with acquired resistance. Thus far, there is no comprehensive analysis of RNA-Seq data from lung cancer patients and none of the available enriched signaling could act as a therapeutic target to re-sensitize the acquired resistant cancer cells to chemo-drugs. Hence, in this study, we aimed to identify the resistance signature for clinical lung cancer patients and explore the regulation mechanism.Method: Analysis of RNA-Seq data from clinical lung cancer patients was conducted in R studio to identify the resistance signature of resistant NSCLC. The resistance signature was validated by survival time of lung cancer patients and qPCR in cisplatin and taxol resistant cells. Cytokine application, Lentivirus-based small-interfering RNA and pharmacological inhibition approaches were applied to characterize the function and molecular mechanism of EREG and downstream signaling in chemoresistance regulation via stemness by western blot, qPCR, cell viability and spheres assays in NSCLC.Results: Thirty-two differentially expressed genes in the treated patients were identified as the resistant genes. The RTK and vitamin D signaling were enriched among resistance genes, where 6 genes were validated as resistance signature and proven to be associated with poor survival in patients. EREG was highly expressed in lung cancer patients and associated with survival time of lung cancer patients. EREG protein promoted the NSCLC resistant to chemo-drug by increasing stemness genes expression. Additionally, inhibition of EREG/ErbB had downregulated ERK signaling, resulted in decreased expression of stemness associated genes and subsequently re-sensitized the resistant NSCLC cells and spheres to chemo-drugs. Conclusions: These findings revealed 6 resistance genes signature and proved that EREG/ErbB regulated the stemness to maintain chemoresistance of NSCLC via ERK signaling. Therefore, targeting EREG/ErbB might significantly and effectively resolve the chemoresistance issue.
Stochastic nuclear organization and host-dependent allele contribution in Rhizophagus irregularis
Authors: Limpens Erik , Creij Jelle van , Auxier Ben , An Jianyong , Wijfjes Raúl Y. , Bergin Claudia , Rosling Anna , Bisseling Ton , Pan Zhiyong
Published: February 2022

Background Arbuscular mycorrhizal (AM) fungi are arguably the most important symbionts of plants, offering a range of benefits to their hosts. However, the provisioning of these benefits does not appear to be uniform among AM fungal individuals, with genetic variation between fungal symbionts having a substantial impact on plant performance. Interestingly, genetic variation has also been reported within fungal individuals, which contain millions of haploid nuclei sharing a common cytoplasm. In the model AM fungus, Rhizophagus irregularis, several isolates have been reported to be dikaryotes, containing two genetically distinct types of nuclei recognized based on their mating-type (MAT) locus identity. However, their extremely coenocytic nature and lack of a known single nucleus stage has raised questions on the origin, distribution and dynamics of this genetic variation. Results Here we performed DNA and RNA sequencing at the mycelial individual, single spore and single nucleus levels to gain insight into the dynamic genetic make-up of the R. irregularis C3 isolate. This isolate is thought to be clonally related to the recently sequenced dikaryon-like A4 isolate, which both were isolated ~ 20 years ago from the same field in Switzerland. Our analyses reveal that both isolates vary considerably in their nuclear behavior. Parallel spore and root culture batches showed widely variable ratios of two main nucleotypes in C3. Additionally, numerous polymorphisms were found that deviated significantly from the distribution of the two main nucleotypes in C3. No consistent host effects on nucleotype ratio after multiple rounds of subculturing were observed. Instead, we found a major effect of host plant-identity on allele-specific expression in C3. Conclusion Our analyses indicate a much more dynamic/variable genetic organization in R. irregularis than previously assumed. Seemingly random fluctuations in nucleotype ratio’s upon spore formation, recombination events, high variability of non-tandemly repeated rDNAs and host-dependent allele specific expression all add levels of variation that may contribute to the evolutionary success of these widespread symbionts.
Correlation and principal component analysis of clinical, bioelectrical and functional variables in newly diagnosed lung cancer adult patients. Pilot study
Authors: Regüeiferos Justa Carmen Columbié , Luna Taira Teresa Batista , Brooks Soraida Cándida Acosta , Rodriguez Maylet Planas , Matamoros Larisa Zamora , Rodríguez Beatríz Legrá , Fernández Arnolis Poll , Bello José Luis García , Pedrón Arquímedes Montoya , González Maraelys Morales , Garcia Julio Cesar Núñez , Fonseca Esmirna Cascaret , Cabrales Luis Enrique Bergues
Published: February 2022

Background: Bioelectrical impedance analysis has been used in cancer patients. The aim of this study is to propose an integrated analysis of clinical, bioelectrical and functional variables in newly diagnosed lung cancer adult patients for the integral evaluation and possible prognostic of them.Methods: This Pilot study was retrospective and cross-sectional and 23 patients aged 53-82 years participated in it. The electrical resistance and capacitive electrical reactance were measured with the Bodystat Quadscan® 4000 analyzer. The electrical impedance modulus and the phase angle were calculated. The serum concentrations of epidermal growth factor, CYFRA21-1 and CA 72-4 were quantified. Correlations/associations among variables and the principal component analysis were suggested.Results: The majority of patients had tumor markers, electrical resistance and the phase angle in their respective normal ranges. The capacitive electrical resistance was below its normal range. Minimum, low and moderate grades of linear correlation/association prevailed among studied variables. The principal components I and II were interpreted as prognosis and body energetic reserve of the patient, respectively.Conclusions: It is concluded that the clinical, bioelectrical and functional variables allow the integral analysis and possible prognosis of newly diagnosed lung cancer adult patients. The decrease of the capacitive electrical reactance is the most influence to the loss of the body energetic reserve that leads to alterations of the overall health, tiredness and decrease of weight and body mass index of these patients.
Metallic chemical potentials in an insulating topological state
Authors: Kotta Erica , Xu Yishuai , Lee Jaewoong , Liu Shouzheng , Miao Lin , Xu Yi , Jiang Denglin , Denlinger Jonathan , Yilmaz Turgut , Vescovo Elio , Cho Beongki , Wray L. Andrew
Published: February 2022

Controlling the density of electrons inside an insulator via the chemical potential is a cornerstone of modern electronics, enabling the electrical conductivity of semiconductors and the emergence of fascinating new properties linked with electronic correlations. The compound SmB6 has drawn widespread attention in recent years as the first insulator to feature both strong electronic correlations and topological quantum order1-7, potentially enabling a host of new phenomenologies as charge density is modified. However, chemical potential has not been experimentally controlled in studies to date of the electronic structure. Here we present an angle-resolved photoemission spectromicroscopy (μ-ARPES) study of SmB6 alloys, using the natural inhomogeneity of sample surfaces to create the analogue of a multi-dimensional doping series. The role of electronic correlations is observed in the interplay of the topologically ordered conducting states with one another and with the chemical potential. Higher doping is found to result in the transformation of these interdependencies as the disorder from impurities erodes quantum coherence. These findings set the stage for a holistic understanding of the interplay between strong correlations and topological features in the electron system. Moreover, they validate recent analyses suggesting that the electronic structure of SmB6 can present the key hallmarks of conventional electron doping, such as a Fermi surface, while nonetheless preserving long-range insulating character in electrical transport measurements8-10.
Instantaneous micropatterning of a double-network hydrogel surface triggered by mechanical force
Authors: Mu Qifeng , Cui Kunpeng , Wang Zhi jian , Matsuda Takahiro , Cui Wei , Kato Hinako , Namiki Shotaro , Yamazaki Tomoko , Frauenlob Martin , King Daniel , Nonoyama Takayuki , Tsuda Masumi , Tanaka Shinya , Nakajima Tasuku , Gong Jian Ping
Published: February 2022

Instantaneous patterning on soft material surfaces, such as hydrogels, is important in various research fields; however, it is extremely challenging. Existing strategies for soft material surface patterning are time-consuming and have poor chemical versatility. Herein, we show how micropatterns can be rapidly created on tough double-network (DN) hydrogel surfaces via sacrificial bonds and mechanical force-triggered radical polymerisation. Micropatterning is performed by local mechanical forces, which initiate radical polymerisation in a process zone in the presence of unsaturated monomers, resulting in on-demand functional patterns with a variety of geometries and chemistries. Such force-triggered activation occurs within seconds and is applicable to diverse monomers. To demonstrate potential applications, we engineered topographies and chemistries on DN hydrogel surfaces to control cell adhesion and water droplet directional transport.
Exploring effective network design for monitoring soil pH and potentially toxic elements based on geochemical surveys in economically developed area
Authors: Xu mingxing , Fu Yesi , Pan Weifeng , Zhou Guohua
Published: February 2022

Periodically visiting soil monitoring sites, i.e., sampling and analysis, is recognized as one of the most important ways to monitor soil quality. However, reconciling the monitoring costs with monitoring precision of the soil monitoring network (SMN) is a key technical problem to be solved. A statistically sound method, which depends on the spatial variation in monitoring indicators, was adopted to determine the number of monitoring sites and the monitoring interval as well as their ability to detect a particular change under an economically feasible scenario. The spatial variation in soil monitoring indicators was inquired from the “Multi-Purpose Regional Geochemical Survey in Zhejiang Province (MRGSZ)” project. Based on the data for soil pH and concentration of potentially toxic elements, the number of monitoring sites and the monitoring intervals that might be used for soil monitoring were determined with the administrative region as the monitoring unit. The results showed that there was great spatial variation in the MRGSZ region, which resulted in discrepancies in the minimum detectable changes (MDCs), monitoring site numbers, and temporal monitoring intervals for revisiting. Our research proposes a number of monitoring sites (nr) that could reconcile the monitoring costs, practicability, and monitoring precision; thus, it was recommended for the design of SMNs. Under nr, the MDC values of each monitoring indicator were acceptable for all administrative regions, and the temporal monitoring intervals were practical with variations of 6.7 to 14.8 years.
A statistical analysis of the relationship between the number of daily earthquakes (M≥5) in the world and the daily beryllium-7 concentrations in the surface air at each of 69 radionuclide monitoring stations in the world
Authors: Ichihashi Masaki
Published: February 2022

The relationship between the number of daily earthquakes (M\(\ge 5)\) in the world and the daily Be-7 concentrations in the surface air at each of 69 stations in the world from September 9, 2001, to December 31, 2017, was statistically analyzed. Aftershocks were not included in the analysis. The number of certified radionuclide stations increased from 5 in 2001 up to 69 in 2017. (1) The median of the numbers (\(n\)) of daily earthquakes (M\(\ge\)5) in the world during the period was 3. Therefore, the observation days of the Be-7 concentrations of each station were classified by \(n\ge 4\)or \(n\le 3.\)The number of stations where the median of the Be-7 concentrations of each station on days of \(n\ge 4\) was greater was 43, and the number of stations where the median of the Be-7 concentrations of each station on days of\(n\ge 4\) were smaller than or equal to that on days of \(n\le 3\)was 26. In more stations (significantly \((p=0.0147)\) by the binomial test), the median of the Be-7 concentrations of each station on days of \(n\ge 4\) was greater than that on the days of \(n\le 3\). In 14 years of total 17 years, in more stations, the median of the Be-7 concentrations of each station on days of \(n\ge 4\) were greater than that on the days of \(n\le 3\). (2) For r = 1 ~ 12 and 15, the observation days were classified into two types, \(n\ge r \text{a}\text{n}\text{d} \text{d}\text{a}\text{y}\text{s} \text{o}\text{f} n\le r-\)1. For 11 classifications of total 13 classifications, the median of the Be-7 concentrations of each station on days of \(n\ge r\) was greater than that on days of \(n\le r-1\) in more stations. For each of 7 classifications, it was significant \((p<0.05\)) by the binomial test. (3) For each station, the inclination of the regression line of the daily Be-7 concentrations with respect to the numbers of daily earthquakes(M\(\ge\)5) in the world was calculated. In more stations (almost significantly (p=0.074) by the binomial test), each inclination was positive. The Be-7 concentrations in the surface air in the world, as a whole, may increase on days when the daily number of earthquakes(M\(\ge\)5) in the world increase.
Towards Renewable Energy Development in EU Region: Analyzing Feasibility of 100% Renewable Energy System for 2050 - Case Study of Cyprus
Authors: ADUN HUMPHREY , ISHAKU Peter , Jazayeri MOEIN , DAGBASI MUSTAFA , OLUSOLA BAMISILE , OKOYE TOCHI
Published: February 2022

Cyprus continues to be one of the European Union's most energy import-dependent countries. It is of worthy note that Cyprus is also the only EU member state whose electricity grid is not connected to the European power network, as it uses an independent network that relies on local production. Furthermore, in a bid to meet the European Union target of 40% renewable energy electricity generation, Cyprus needs to fully utilize the vast renewable energy potential in the region. In this study, the integration of dominant renewable energy sources (solar, wind, and concentrated solar power) to the thermal power run grid system is simulated. Also, a 100% renewable energy electricity generation for 2050 is also modelled. The analysis is done, for a projected 8.3TWh/year of electricity demands, in the ENERGYPLAN simulation environment. The deterministic factors considered in this study are the power production and critical excess electricity production. Eight (8) case scenarios were developed in this study for comparative discourse of most feasible electricity generation to cut down on carbon dioxide emission in Cyprus. The optimized analysis reveals that the best case scenario for electricity generation for 2050 is PV system integrated with the oil powered plants. This system (PV/Oil) would generate 1.68TWh/year of renewable energy electricity. For 100% renewable energy electricity generation, the most feasible option is the PV/Wind/storage system. This system would have an installed 4000MW PV capacity, 7500MW wind capacity and 30GWh storage capacity.
UHRF1 Modulates Breast Cancer Cell Growth via Estrogen Signaling
Authors: Luo Guosheng , Li Quanhui , Yu Miao , Wang Tianshi , Zang Yifeng , Liu ZiPing , Niu Zhiguo , Yang Huijie , Lai Jianghua
Published: February 2022

The ubiquitination process, which involves that binding of an ubiquitin protein to certain substrates, regulates several human biological processes and human cancers. Several studies report that the abnormal expression of quite a few E3 ubiquitin ligases could play critical role in carcinogenic process and cancer progression. In our current study, we identify UHRF1 (Ubiquitin Like with PHD And Ring Finger Domain 1) is an important regulator for breast cancer growth. UHRF1 depletion significantly decreases breast cancer growth in vitro and in vivo. Clinical data analysis reveals that UHRF1 is dramatically elevated in breast cancer, compared to normal breast tissue. UHRF1 correlates with poor survival in Luminal type of breast cancer patients, but not in ER negative groups. The molecular biological studies show that UHRF1 localizes in the nuclear and interact with ERα via its SRA domain, which subsequently inhibits K48-linked ubiquitination of ERα and enhances ERα stability. Our study provides a novel function of UHRF1 in regulation estrogen signaling in breast cancer and a promising target for breast cancer therapeutics.
NPM1 is a prognostic biomarker and correlated with clinicopathological characteristics in gastric cancer
Authors: Liu Hong-Bin , Guo Chang-An , Su Xiao-Lu , Wang Wen-Jie , Xia Tian-Hong , Cao Xiao-Meng , Yuan Shao-Bin , Wang Wen-An , Zhang An
Published: February 2022

Background and aims: NPM1 plays an important role in the occurrence and development of leukemia, and its role in some solid tumors has gradually received attention. The purpose of this study is to explore the expression of NPM1 in gastric cancer (GC) tissues, to study the relationship between NPM1 expression and clinicopathological characteristics of GC patients, and to study the influence of NPM1 expression levels on the prognosis of GC patients. Methods: The study was conducted from tissue samples obtained after radical gastrectomy in 106 patients with GC. We used tissue microarray immunohistochemical analysis to examine the expression level of NPM1 in different GC and adjacent tissues, and finally analyzed the relationship between NPM1 expression, clinicopathological factors and survival rate. Results: Compared with the corresponding adjacent tissues, NPM1 is low-expressed in 75.5% of GC tissues. High NPM1 expression group was associated with better overall survival rate and disease free survival rate compared to low NPM1 expression group with GC (p<0.01). Conclusion：The assessment of NPM1 expression in GC samples may represent a useful tool for GC diagnosis and prognostic prediction. Nonetheless, our study should be regarded as a preliminary study, and its predictive value as a single-center retrospective study is limited.
Factors That Influence Mental Health Of University And College Students In The UK: A Rapid Review
Authors: Campbell Fiona , Blank Lindsay , Cantrell Anna , Baxter Susan , Blackmore Christopher , Dixon Jan , Goyder Elizabeth
Published: February 2022

Background: Worsening mental health of students in higher education is a public policy concern and the impact of measures to reduce transmission of COVID-19 has heightened awareness of this issue. Preventing poor mental health and supporting positive mental wellbeing needs to be based on an evidence informed understanding what factors influence the mental health of students. Objectives: To identify factors associated with mental health of students in higher education.Methods: We undertook a rapid review of observational studies that measured factors associated with student mental wellbeing and poor mental health. Extensive searches were undertaken across five databases. We included studies undertaken in the UK and published within the last decade (2010-2020). Due to heterogeneity of factors, and diversity of outcomes used to measure wellbeing and poor mental health the findings were analysed and described narratively.Findings: We included 30 studies, most of which were cross sectional in design. Those factors most strongly and consistently associated with increased risk of developing poor mental health included students with experiences of trauma in childhood, those that identify as LGBTQ and students with autism. Factors that promote wellbeing include developing strong and supportive social networks. Students who are prepared and able to adjust to the changes that moving into higher education presents also experience better mental health. Some behaviours that are associated with poor mental health include lack of engagement both with learning and leisure activities and poor mental health literacy. Conclusion: Improved knowledge of factors associated with poor mental health and also those that increase mental wellbeing can provide a foundation for designing strategies and specific interventions that can prevent poor mental health and ensuring targeted support is available for students at increased risk.
A mechanosensitive vascular niche for Drosophila hematopoiesis
Authors: Crozatier michele , Tian Yushun , Morin-Poulard Ismaël , Vanzo Nathalie
Published: February 2022

Hematopoietic stem and progenitor cells maintain blood cell homeostasis by integrating various cues provided by specialized microenvironments or niches. Biomechanical forces are emerging as key regulators of hematopoiesis. Here we report that mechanical stimuli provided by blood flow in the vascular niche control Drosophila hematopoiesis. In vascular niche cells, the mechanosensitive channel Piezo transduces mechanical forces through intracellular calcium upregulation, leading to Notch activation and repression of FGF ligand transcription, known to regulate hematopoietic progenitor maintenance. Our results provide insight into how the vascular niche integrates mechanical stimuli to regulate hematopoiesis.
Identification and quantification of Cinnamomum camphora seeds extract and development of citric acid and polyphenols based carboxymethyl chitosan-gum Arabic hybrid film for intelligent packaging applications
Authors: Alnadari Fawze , Bassey Anthony Pius , Abdin Mohamed , Salama Mohamed Abdelbaset , Nasiru Mustapha Muhammad , Dai Zhuqing , Hu Yuhang , Zeng Xiaoxiong
Published: February 2022

In this study, carboxymethyl chitosan with gum Arabic (CG) based novel functional films containing Cinnamomum camphora seeds extract (CCSE) at varying concentrations (0.5, 1.2 and 2% in w/w) were successfully fabricated. Moreover, sixteen phenolic compounds were identified by LC-ESI-QTOF-MS and the most abundant organic acid was citric acid (present at 1062.55 µg/g dry weight in CCSE). SEM showed that higher extract concentration indicated a homogeneous surface and more stability of films. CCSE inclusion into CG resulted in a marked increase (33.01 to 63.23 MPa) of tensile properties, with optimum thickness. The swelling degree, water solubility, and water vapor permeability were markedly (p < 0.05) reduced from 54.21 to 31.70%, 32.05 to 14.02%, and 3.46 to 1.12 × 10−11g−1s−1Pa−1, respectively. The open control and CG samples showed much higher peroxide values of sunflower oil (69.49 ± 0.68 and 20.15 ± 0.31 mEq/kg, respectively) while CG-CCSE2 exhibited a low value (9.79 ± 0.28 mEq/kg) after 28 days incubation. The good antioxidant and antimicrobial properties exhibited by the fabricated films demonstrated their potential use in the food packaging industry.
Fabrication and Response Optimization of Moringa Oleifera-Functionalized Nanosorbents for the Removal of Diesel Range Organics from Contaminated Water
Authors: Chima Ubah Promise , Dashti Arezoo Fereidonian , Saaid Mardiana , Imam Saifullahi Shehu , Adnan Rohana
Published: February 2022

The purpose of this research is to synthesize environmentally friendly nanosorbents capable of Diesel Range Organics (DRO) adsorption from contaminated water. Central Composite Design (CCD) analysis of response surface methodology (RSM) was employed in a model fitting of the variables predicting the adsorption efficiency of Moringa Oleifera-functionalized zerovalent iron particles (ZINPs) for the removal of DRO. The effects of the reaction parameters on the response were screened using 24 factorial design to determine the statistically significant independent variables. A quadratic model predicting the DRO adsorption efficiency of ZINPs with an F-value of 276.84 (p-value <0.0001) was developed. Diagnostic plots show that the predicted values were in excellent agreement with actual experimental values (R2 = 0.99). The maximum percentage removal of DRO of 92.6% was achieved after optimization, using the synthesized ZINPs after 8 hours of contact between DRO substrates and ZINPs at pH of 8, the temperature of 25 ºC, with an adsorbent dosage of 2 g/L and at composite desirability of 1. Characterization of ZINPs revealed the formation of quasi nanospheres and nanocubes with an average particle diameter of 50.9 ± 9.7, the crystallite size of 15.31 nm, a crystallinity index of 32.47%, and pore width of 75.69 – 88.59 nm. The adsorption equilibrium data modelling of ZINPs for adsorption of DRO was best described by Langmuir isotherm with the maximum monolayer coverage capacity of 7.194 mg/g. The separation factor T, indicated favourable adsorption. The adsorption kinetic data were consistent with pseudo-second-order kinetics indicating probable chemisorption.
Utility Of Support Vector Machine And Decision Tree To Identify The Prognosis Of Metformin Poisoning In The United States: Analysis Of National Poisoning Data System
Authors: Mehrpour Omid , Saeedi Farhad , Hoyte Christopher , Goss Foster , Shirazi Farshad M
Published: February 2022

Background: With diabetes incidence growing globally, and metformin still being the first-line for its treatment, metformin’s toxicity and overdose have been increasing. Hence, its mortality rate is increasing. For the first time, we aimed to study the efficacy of machine learning algorithms in predicting the outcome of metformin poisoning using two well-known classifications methods including support vector machine (SVM) and decision tree (DT). Methods: This is a retrospective cohort study of National Poison Data System data which is the largest data repository of poisoning cases in the United States. The SVM and DT algorithms developed using training and test datasets. Results: The overall accuracy of the SVM and DT model were 85% and 89%, respectively. Our model showed that acidosis, hypoglycemia, electrolyte abnormality, hypotension, elevated anion gap, elevated creatinine, tachycardia, and renal failure are the most important determinants in terms of outcome prediction of metformin poisoning. Furthermore, we found that the accuracy of the SVM was higher than the DT model, so it could perform more efficiently to predict the outcomes.Conclusions: In order to predict the prognosis of metformin poisoning, machine learning algorithms are very effective, and may help clinicians in the process of management and follow up of the metformin poisoning cases.
Decoding an ancient biological control: The kairomonal basis of fruit fly repellence from weaver ants
Authors: Kempraj Vivek , Park Soo Jean , Cameron Donald , Taylor Phillip W.
Published: February 2022

Humans have used weaver ants, Oecophylla smaragdina, as biological control agents to control insect pests in orchards for many centuries. Over recent decades, the effectiveness of weaver ants as biological control agents has been attributed in part to kairomones produced by the ants, but the chemical identity of these kairomones has remained unknown. We have identified the kairomone responsible for deterrence by O. smaragdina, providing a significant advance in understanding the chemical basis of their predator/prey interactions. Olfactometer assays with extracts from weaver ants demonstrated headspace volatiles to be highly repellent to Queensland fruit fly, Bactrocera tryoni. Using electrophysiology and bioassays, we demonstrate that this repellence is induced by a single compound, 1-octanol. Of 16 compounds identified in O. smaragdina headspace, only 1-octanol evoked an electrophysiological response from B. tryoni antennae. Flies had greatly reduced oviposition and spent significantly less time in an olfactometer arm in the presence of 1-octanol or a synthetic blend of headspace volatiles containing 1-octanol than in the presence of a synthetic blend of headspace volatiles without 1-octanol, or clean air. Taken together, our results demonstrate that 1-octanol is the functional kairomone component of O. smaragdina headspace that explains repellence and oviposition deterrence, and is hence an important contributor to the effectiveness of these ants as biological control agents.
Establishment of Yan-Zhang's Staging of Digestive Tract Magnetic Compression Anastomosis in a Rat Model
Authors: Zhang Miaomiao , Lyu Xin , Zhao Guangbin , An Yingfeng , Lyu Yi , Yan Xiaopeng
Published: February 2022

Magnetic compression anastomosis, also known as magnamosis, is a safe and feasible method for gastrointestinal anastomosis. However, the pathological process involved in magnamosis of the digestive tract has not been investigated. This study aimed to establish the stages of digestive tract magnamosis in a rat model. Eighty-four Sprague-Dawley albino rats (200–250 g) were randomly divided into 14 groups (n = 6 per group). All rats underwent colonic magnamosis. Starting from postoperative day (POD) 1, one group of rats was sacrificed every other day to obtain the specimens. Burst pressure at the anastomotic site of each specimen was examined. Gross and histological examination of the anastomotic site was performed to establish the stages of the digestive tract magnamosis. Colonic magnamosis was successfully performed in all rats and the mean anastomosis time was 5.62 ± 0.91 min. The postoperative survival rate was 100%. The lowest anastomotic burst pressure was 78.33 ± 3.44 mmHg on POD3. The anastomotic burst pressure gradually increased and stabilized on POD21. Macroscopic and histological examination showed that the anastomotic mucosal and serosal layer did not heal on POD1. The serosal layer of the anastomosis healed by adhesion on POD3, and the mucosal layer began to heal on POD3-11 and was established by POD21. According to the anastomotic bursting pressure, gastrointestinal magnamosis can be divided into the magnetic maintenance, fragile, strengthening, and stable period, which correspond to serosal adhesion formation, serosal healing, mucosal healing, and stereotyping, respectively, based on histological changes.
Preliminary Application of Three-Dimensional Printing in Congenital Uterine Anomalies Based on Three-Dimensional Transvaginal Ultrasonographic Data
Authors: Wang Li , Chen Xu-Jiao , Liang Jia-He , Zhang Ze-Kai , Cao Tie-Sheng , Zhang Li
Published: February 2022

Background: The three-dimensional (3D) printing technology has remarkable potential as an auxiliary tool for representing anatomical structures, facilitating diagnosis and therapy, and enhancing training and teaching in the medical field. As the most available diagnostic tool and it is routinely used as the first approach in diagnosis of the uterine anomalies, 3D transvaginal ultrasonography (3D-TVS) has been proposed as non-invasive “gold standard” approach for these malformations due to high diagnostic accuracy. Despite holding promise of manufacturing 3D printed models based on 3D-TVS data, relevant reports about 3D-TVS derived gynecological 3D printing haven’t been reported to the best of our knowledge. We found an opportunity to explore the feasibility of building 3D printed models for the abnormal uterus based on the data acquired by 3D-TVS.Methods: The women suspected with congenital uterine anomalies (CUAs) were enrolled in the study. The diagnose of CUAs were made by 3D-TVS scanning and further confirmed under the hysteroscopy examination. One volunteer with normal uterus was enrolled as control. All subjects underwent 3D-TVS scanning for 3D printing data collection. Acquired images were stored and extracted as DICOM files, then processed by professional software to portray and model the boundary of the uterine inner and outer walls separately. After the computer 3D models were constructed, the data were saved and output as STL files for further surface restoration and smoothing. The colors of endometrium and uterine body were specified, respectively, in the print preview mode. Then the uncured photosensitive resin was cleaned and polished to obtain a smooth and transparent solid model after printed models were cooled down.Results: 3D printing models of normal uterus, incomplete septate uterus, complete septate uterus, uterus didelphys and unicornuate uterus were produced on ultrasonographic data of 3D-TVS.Conclusions: Our research and practice made the first try in modeling CUAs successfully based on ultrasonographic data entirely, verifying that it’s a feasible way to build 3D printed models of high-quality through 3D-TVS scanning.