bluuebunny/crossref_metadata_2025 huggingface dataset:
Methodological Approaches to Managing Long-Term Development of Organization
Authors: Bobkov A. L.
Published: January 2025

The article studies methodological approaches to management of the long-term development of organization proposed by the author. They are based on results of earlier investigation of regularities in changing production structure of overseas and Russian organizations of different economy sectors and the model of production structure development elaborated on their basis. A key distinguishing feature of these methodological approaches to management of the long-term development of organizations is choosing two principle types of organization production structures and the use of statistical models to identify moments of organizational transformation, i. e. altering the type of production structure as the organization grows and develops. The author puts forward a new set of tools to manage long-term development of organizations, including a model of developing production structure for organizations of respective industry, a statistical model of organization efficiency growth in the process of development and methodology of statistical forecast for the limit of organization attainable growth. The use of these tools could provide an opportunity for company top-management to conduct efficient management of organization in the log-term period due to finding regularities in organizational transformation and statistical forecasting moments of their arising.
Significance and Necessity of Statistics on Wood Waste in Circular Economy Project Implementation at Forest-Industry Complex
Authors: Danilov A. A. , Yashalova N. N.
Published: January 2025

Production waste in forest-industry complex of economy is an important ecologic problem, which could be resolved by business entities changing-over to circular economy. Statistics on the amount of wood waste is essential for realizing the concept of closed-cycle economy in forest-industry complex. The article provides information about volumes of wood waste in the Russian Federation. The authors studied nature of wood waste and its classification, analyzed theoretical experience in estimating the amount of wood waste, provided calculations of wood waste being formed in home forest-industry complex. Priority trends in the field of wood waste recycling are demonstrated. The article can be interesting both for scientists and practical experts studying problems of forest-industry complex changing-over to the closed-cycle economy.
Current Concepts and Approaches to Development of Transport Engineering Enterprises
Authors: Bezdelov A. D.
Published: January 2025

The research has enriched theoretical base of developing enterprises of transport machine-building, which includes systematization of principle stages of industry development, identification of key events and their after-effects and it can demonstrate higher rates and frequency of new technology arising that transforms approaches and strategies of transport engineering progressing. The article studies classifications of today’s concepts and approaches to the development of transport machine-building by groups that differ from each other in priority trends of managing enterprises of this industry and other industries of economy. The research shows that it is possible to find differences in approaches to management of transport engineering between Russian scientists and experts and their foreign colleagues, which can be connected with cultural and political characteristics of the present development of countries, however, the global trend on wider use of innovation technologies, such as business digitalization, automation of processes, new materials, approaches to organizational structure, etc. is still retained. Leading companies and research institutes keep working at introduction of AI, the Internet of things and blockchain technologies to optimize logistic chains and management of transportation stock.
Elaborating Development Strategy and Finance Strategy of Company
Authors: Lyandau Yu. V. , Sudakov D. K.
Published: January 2025

The article studied the approach to elaboration of development strategy of organization, as well as functional strategy being an integrative part of the principle strategy of the company. First of all, the mission and vision of the company are defined and strategic analysis of the organization aimed at shaping strategic initiatives is carried out. To start with, external factors are estimated by STEEPLE and then EFAS-resume is formed. Later information from EFAS-resume gets to SWOT-analysis and internal strong and weak sides of the company are identified. Then the correlation matrix is plotted, which provides max values and the compensation matrix is formed to describe strategic initiatives necessary for elaboration of development strategy of the company. Elaboration of company strategy is accomplished with the help of well-balanced system of indicators, which consists of the strategic map and the table of goals, indicators and corresponding events. The author provided the process of elaborating development strategy of the company and finance strategy being an integral part (functional strategy) of the principle strategy of the organization.
Айтрекинг как инструмент медицинской диагностики
Authors: Шелепин Евгений Ю. , Скуратова Ксения А. , Лехницкая Полина А. , Шелепин Константин Ю.
Published: January 2025

Introduction. The transition to personalized, predictive and preventive medicine, high-tech healthcare and health-preserving technologies is one of the priorities of scientific and technological development in the next decade. The possibility of using eye tracking for medical diagnostics meets this priority.
Eye tracking as a tool for medical diagnostics. Using eye tracking, disease detection is based on the main types of eye movements: fixations, saccades and nystagmus. However, protocols that allow a comprehensive assessment of the patient's condition have not been fully validated. The purpose of the current review is an attempt to consider studies in the Scopus, Web of Science, and RSCI databases regarding the utilizing of eye tracking as an addition to the diseases and disorders diagnosis, and to outline possible trajectories for the development of this method in the field of medicine. The article provides examples of the use of eye tracking in dementia, mild cognitive impairment, Alzheimer's disease, schizophrenia, schizotypal and delusional disorder, mood disorder, attention deficit syndrome, the consequences of a stroke, and head injuries.
Results and discussion. Eye tracking is characterized by objectivity, brief and stress-free observation of a patient, the ability to simplify the tasks presented with high diagnostic accuracy, finding a simulated disorder, supplementing existing tests, searching for latent signs, higher sensitivity compared to some neuropsychological tests, the ability to dynamically switch between tasks. As a prospect for developing diagnostic protocols based on eye tracking, it is possible to: use existing paradigms for conducting eye tracking studies, combine new paradigms with existing neuropsychological tests and methods, inherit the basic principles of examining the patient's condition, and build data analysis models. Validation on a wider sample and clarification of the list of stimuli are necessary.
Инклюзивный потенциал семей, воспитывающих детей с расстройствами аутистического спектра
Authors: Кудрявцев Владимир А. , Каштанова Светлана Н.
Published: January 2025

Introduction. Working with the family of a disabled child in the context of its support combines special education, education, family psychology, and sociology. This paper is based on the analysis of measurable parameters of parental effectiveness in families raising children with autism spectrum disorders as a result of testing the mechanisms for assessing and studying inclusive potential.
Methods. The study included 160 families raising children with autism spectrum disorders. The parameters of family functionality were groups of competencies, and the indication was measuring the degree of parental inclusiveness expertise. The study used the Self-Assessment of Parental Inclusiveness and the Expert Assessment of Inclusive Potential questionnaires developed by the authors. The results of the analysis were indicators of expert accordance and non-accordance in the form of overestimation or underestimation of subjective assessments.
Results. Structured data on subjective expert assessments of family functionality were obtained in the context of five basic groups of competencies, including information-related, communicative, value- and meaning-related, personal, and educational competencies. Subjective attitudes towards information and communication support received from various services and departments were revealed. The problem of a unified family approach to the issue of encouraging and stimulating children was addressed. Data on the level of psychological and emotional comfort, attitudes towards the prospects for development and the specificity of attitudes towards the child and his defect were presented. The shortcomings and problems in the development of inclusive family competence are a lack of parental awareness of the special educational needs of children and the necessary special conditions, a lack of conflict-free communication skills, a lack of family education resources and parents’ personal resources. Analyzing adaptability, educational resources, personal maturity, ecological compatibility in relationships, availability and quality of channels for receiving assistance help determine priority areas and the nature of targeted psychological and educational support for families raising children with autism spectrum disorders.
Discussion. The proposed framework for the quantitative and qualitative analysis and evaluation of parental competency enables us to reconsider the nature of interaction with families raising children with autism spectrum disorders and to change the system of their psychological and educational support.
Особенности саморегуляции поведения и принятия решений студентов с разными стилями и стратегиями смыслопередачи
Authors: Суроедова Елена А. , Попов Дмитрий И. , Вертий Екатерина Ю.
Published: January 2025

Introduction. In the modern educational space, characterized by dynamism, information saturation and multitasking, the study of the process of meaning transmission, self-regulation of behavior and decision-making by students come to the forefront in the context of their academic and professional success. The aim of our research is to study the peculiarities of self-regulation of behavior and decision-making in students with different styles and strategies of meaning- transmission in the process of solving educational and professional tasks.
Methods. The study involved 72 students, including 64 girls, 8 boys, average age 21.1 years. Natural experiment, questionnaire and survey were used as research methods. Research methods: Questionnaire "Strategies of meaning-transmission" (Suroedova, 2011); Questionnaire "Style of self-regulation of behavior" by V.I. Morosanova (Morosanova, 2004); Melbourne Decision Making Questionnaire (Kornilova, 2013).
Results. We identified the styles of meaning-transmission: neutral, emotional, declarative, philosophical. The study found that there are significant differences in self-organization of activity and decision-making styles in students with different styles and strategies of meaning-making. Students with an active strategy of meaning-transmission are distinguished by developed skills of goal setting, planning and controlling the process of activity, they tend to collect information from different sources and consider alternative ways of solving problems, choosing the most effective. Respondents with the emotional style of meaning-transmission are distinguished by a high level of development of goal- setting and activity programming, evaluation of intermediate and final results of problem-solving, they show flexibility in choosing ways and means of solving a problem situation. 
Discussion. The results of our study can contribute to the development of psychological and pedagogical technologies aimed at improving the effectiveness of learning and assimilation of professional knowledge, taking into account the students' abilities to make meaning.
Существует ли связь генетических предикторов и психологических характеристик с эффективностью психотерапии?
Authors: Ермаков Павел Н. , Ковш Екатерина М. , Воярж Анастасия Е. , Максимов Алексей Ю. , Титова Инна И.
Published: January 2025

Introduction. The scientific review presents the results of the analysis of modern literature devoted to the study of the relationship of genetic, epigenetic and psychological factors with the effectiveness of psychotherapy. 
Theoretical justification. Statistical data indicate that in the Russian Federation, taking into account the socio-political transformations of recent times, the population's need for psychological and psychotherapeutic assistance is increasing every year. Despite this, it is still not included in the health insurance. This is largely influenced by the lack of sufficient evidence base confirming the effectiveness of various psychological and psychotherapeutic approaches. The creation of such a system is possible based on the fundamental biological mechanisms underlying mental processes. These include, among others, genetic and epigenetic predictors. The article discusses the basic concepts of genetics and epigenetics related to psychological characteristics and the psychotherapeutic process. Models of correlation and interaction between genes and the environment are described. The results of the analysis of scientific literature devoted to the study of the influence of the carrier of "plasticity alleles", as well as genes of neurotransmitter systems on the effectiveness of psychotherapy are presented. The factors of the social environment that have a significant impact on neurobiological development are described. The relationship of the severity of DNA methylation processes with traumatic experiences on the one hand and with the effects of psychotherapeutic assistance on the other is described. The features of the relationship of methylation profiles with the psychotherapeutic effect are described. The analysis of the relationship of genetic predictors and psychological characteristics with the use of methods of cognitive behavioral therapy, therapy of PTSD, BPD, panic disorders, depression.
Discussion. The analysis of modern scientific literature on the topic allows us to conclude that the DNA methylation index can be used as a predictor of effectiveness and an indicator of the response to psychotherapy. In the future, knowledge of the relationship between genetic predictors and psychological characteristics with the effectiveness of psychotherapy can be used to develop personalized programs aimed at providing psychological assistance.
Выбор позиций взаимодействия: Темная и Светлая триады как предикторы поведения
Authors: Маралов Владимир Г. , Кудака Марина А. , Смирнова Ольга В.
Published: January 2025

Introduction. It is important to identify factors that influence the choice of interaction positions and behavioral strategies. The Dark Triad (Machiavellianism, narcissism, and non-clinical psychopathy) and the Light Triad (faith in humanity, humanism, and Kantianism) can act as integrated factors in choosing an interaction position. This study represents the first attempt to investigate the role of the Dark Triad and Light Triad in students’ choice of interaction positions – coercion, manipulation, non-violence, and non-interference. Methods. The sample comprised of 206 students of Cherepovets State University (range: 17–24 years, mean age: 18.4 years). Research methods: (a) Short Dark Triad by Jones and Paulhus (modified by Egorova, Sitnikova, and Parshikova), (b) the Light Triad Scale by Kaufman, Yaden, Hyde, Tsukayama, and (c) the questionnaire to identify interaction positions developed by the authors. Methods of descriptive statistics, correlation and regression analysis were used. Results. When choosing interaction positions, students prefer the positions of non-violence and non-interference rather than positions of coercion and manipulation. The Light Triad traits prevail over the Dark Triad traits. The Dark Triad is positively correlated with the positions of coercion and manipulation while the Light Triad is negatively correlated. The main role in choosing the positions of coercion and manipulation is played by psychopathy, Machiavellianism and a low level of Kantianism. The Light Triad is positively associated with the position of non-violence. The greatest influence on its choice is the belief in humanity, as long as there are no traits of non-clinical psychopathy. The position of non-interference had no positive connections with the Dark Triad and Light Triad. However, its choice can be influenced in some cases by such a trait of the Dark Triad as Machiavellianism.  Discussion. The Dark Triad and Light Triad play an important role in students’ choice of interaction positions. The results obtained in this study can be used both for scientific and practical purposes to develop a non-violent position among students.
Влияние факторов семейного воспитания на развитие цифровых навыков ребенка с умственной отсталостью
Authors: Королева Юлия А.
Published: January 2025

Introduction. The article is devoted to the problem of mediating the development of digital skills of a child with mental retardation in the conditions of family upbringing. Family upbringing factors have a significant impact on the process of developing these skills in children: material and technical equipment of the family, parents' media activity and their digital skills, digital parental mediation strategies, parents' attitudes towards the possibilities of the digital environment in the child's socialization. The relevance and novelty of this study lies in describing a number of factors of family upbringing and identifying their relationship with digital skills of a child with mental retardation. Methods. Two groups of parents participated in an online survey: those raising children and adolescents with mental retardation (N = 42 people) and parents of normally developing children and adolescents (N = 52 people). Results. The study showed that parents raising children with mental retardation are characterized by less media activity, predominance of communicative motive of Internet activity, and greater awareness of children's practices in the digital environment. At the same time, parents of children with intellectual disabilities use digital mediation strategies less often, and trust the Internet less as a source of development of cognitive sphere and formation of children's information processing skills. Parents of children with disabilities rate their digital skills higher than those of their children. The study proved the correlation of digital skills of a child with mental retardation with some factors of family upbringing. Discussion. The correlations found between the digital skills of children with mental retardation and the digital skills of parents, the number of digital devices in the family, and the availability and quality of these digital tools indicate the need to develop and implement programs to educate parents, develop their digital skills, and master various digital mediation strategies in the process of raising a child with mental retardation.
Интересность текста: подходы к изучению и методы оценки в психолого-педагогических исследованиях
Authors: Тюменева Юлия А. , Кащенко Екатерина С. , Лебедева Мария Ю.
Published: January 2025

Introduction. Text interestingness is often considered a standalone motivational factor in education, making it a popular subject in psychological and educational research. The purpose of this review is to structure the information on the methodology for assessing text interestingness, identify the limitations, and highlight the intersections of various methods. Theoretical justification. Existing studies on text interestingness mainly stem from the linguistic approach, appraisal theory of interest, and individual interest theory. Using grounded theory as a method of literature analysis allowed us to identify three approaches to interestingness in research: (1) interestingness based on text characteristics, (2) interestingness based on reader characteristics, and (3) interestingness as a perceived characteristic of the text by the reader. Analysis of assessment methods revealed that each approach prioritizes its specific methods. The text-based approach describes the most objective linguistic (formal and discourse-content) assessments. In the reader-based approach, knowledge tests and self-reported assessments of individual and subject-specific interests are common. The approach to interestingness as a perceived characteristic of the text mainly utilizes subjective scaling and rating methods. Discussion. Each approach has advantages and disadvantages, and although their methods differ, they are sometimes interconnected. There is an increasing number of constructs related to interestingness. It is not so much the variety of methods, but the proliferation of synonymous constructs that may hinder the integration of research results on text interestingness.
Жизнестойкость и восприятие времени как личностные ресурсы саморегуляции
Authors: Селезнева Юлия В. , Комерова Наталья Е. , Тарасова Анастасия Ю.
Published: January 2025

Introduction. Today's world is facing increased uncertainty and new geopolitical risks. In crisis conditions of society development it is necessary to study personal resources of conscious self-regulation among people who are in a difficult life situation. Our study aims to explore the personality resources of conscious self-regulation of people living in the zone of local armed conflict. Methods. The sample was 230 people. We used Zimbardo Time Perspective Inventory, Hardiness Survey by S.R. Maddi, Conscious Self-Regulation Profile Questionnaire by V.I. Morosanova, Action Control Scale J. Kuhl, U-Mann-Whitney statistical test, r-Spearman correlation coefficient. Results. "Past Negative" time perspective is correlated with low hardiness; Future orientation provides high levels of hardiness and the capacity to project and planning. Action orientation and an ability to realize one's intentions are associated with high hardiness and resilience, future orientation, the ability to be flexible, and to correct the program of actions. Discussion. Time perception and hardiness are significant resources of self-regulation that influence its functional, operational-technical and psychological components.
Própolis no desempenho produtivo e qualidade de ovos de poedeiras Isa Label
Authors:   , Costa Monik Kelly de Oliveira
Published: January 2025

Objetivou-se avaliar a influência da adição de extrato hidroalcoólico de própolis em rações com dois níveis de proteína bruta, no desempenho produtivo e qualidade de ovos de poedeiras Isa Label criadas em ambiente de alta temperatura. Foram utilizadas 104 aves, distribuídas em delineamento inteiramente casualizado, esquema fatorial 2x2 (proteína bruta e extrato hidroalcoólico de própolis), sendo uma ração controle e outra com redução de 5% da proteína bruta, cada uma com e sem a adição de 0,70% de extrato hidroalcoólico de própolis, com 13 repetições e 2 aves por unidade experimental. Foram avaliados: taxa de postura, conversão alimentar, peso absoluto e relativo de gema, albúmen e casca, altura e largura do ovo, gravidade específica, coloração da gema, espessura de casca, unidade Haugh, índice de albúmen e de gema. O extrato hidroalcoólico (0,70%) proporcionou aumento da taxa de postura e melhora da conversão alimentar, ao nível de proteína de 17,70%, além de promover coloração mais acentuada da gema. Portanto, o nível de 0,70% de extrato hidroalcoólico de própolis pode ser usado em rações para poedeiras Isa Label, já que melhora características desejáveis como taxa de postura, conversão alimentar e coloração da gema, quando as rações têm nível de proteína de 17,7%. E o nível de proteína de 16,82% pode ser usado para poedeiras Isa Label, sem prejuízo no desempenho.
Efeitos da Sazonalidade Sobre o Perfil Mineral em Caprinos Criados no Semiárido
Authors:   , Lima Joseney Maia de
Published: January 2025

Objetivando avaliar os efeitos da sazonalidade sobre o perfil mineral de caprinos, cinquenta machos foram divididos em dois grupos, um grupo com suplementação
mineral e outro controle, e mantidos em pastagem de caatinga nativa em propriedade na região semiárida. A avaliação sazonal foi realizada em quatro períodos: fim do período seco, meio do chuvoso, início do período seco e meio do período seco. Para avaliação do acúmulo mineral, foram realizadas biopsias de costela e fígado e coleta de sangue a cada período. As concentrações de cálcio (Ca), fósforo (P), cobre (Cu), ferro (Fe), molibdênio (Mo), zinco (Zn) e cobalto (Co), foram determinados através de Espectrometria de emissão óptica por plasma acoplado indutivamente, após digestão
nítrico-perclórica. Foram constatados valores séricos e ósseos normais de cálcio e fósforo em ambos os grupos e períodos, assim como os níveis séricos e hepáticos de molibdênio. Observou-se valores séricos e hepáticos elevados de ferro em todos períodos. Por outro lado, as concentrações séricas de cobre do grupo controle no final
do período seco se mostrou dentro da faixa considerada crítica para deficiência e níveis hepático deficiente em todos os períodos sazonais. Foi observado deficiência hepática
de zinco no início e meio do período seco e deficiência sérica de cobalto no grupo controle no final do período seco e meio do período chuvoso. Sugere-se o fornecimento de suplemento mineral específico, formulado para animais criados no semiárido, permitindo redução de custos.
Xenotransplante de ovário bovino na cápsula renal de camundongas BALB/c Nude e C57BL6 SCID estimuladas com eCG ou associação de FSH e LH
Authors:   , Pimentel Muriel Magda Lustosa
Published: January 2025

O objetivo desse trabalho foi de avaliar a viabilidade do xenotransplante de tecido ovariano de novilhas sob a cápsula renal de dois modelos de camundongas imunodeficientes e posteriormente estimuladas hormonalmente. Para tanto, animais das linhagens BALB/c Nude n = 9 e C57BL6 SCID n = 12 receberam fragmentos de sete ovários de novilhas. Os tecidos corticais ovarianos foram levados diretamente para histologia clássica (controle) ou transplantados sob a cápsula renal das receptoras, e permaneceram por 60 dias. Após cinco dias da cirurgia, foi iniciado o lavado vaginal, a cada 12 horas, durante 55 dias e divididas em três grupos, cada um com três BALB/c Nude e quatro C57BL6 SCID, onde o grupo um foi o controle, o grupo 2 estimulado hormonalmente com eCG e o grupo três, com uma associação de FSH+LH. O uso de termografia infravermelha para avaliação do tecido ovariano se deu no momento da coleta do ovário no abatedouro, logo após o transplante e no momento da retirada do mesmo. Amostras de tecidos e sangue foram colhidos e encaminhados para histologia clássica e bioquímica hepática e renal. As durações das fases do ciclo estral, os dados termográficos e bioquímicos foram avaliados por ANOVA seguidos de teste de Tukey (p<0,05). O tempo cirúrgico médio em ambos os modelos não excedeu 18 minutos. Os animais C57BL6 SCID possuíam uma capsula renal mais elástica, facilitando a inserção dos fragmentos quando comparado às BALB/c Nude, o desenvolvimento e vascularização foi constatado em 83% das C57BL6 SCID e 77% das receptoras BALB/c Nude, com retorno da atividade ovariana 19 e 9 dias após o transplante, respectivamente. Observou-se ainda a presença de corpo hemorrágico nos transplantes induzidos com a associação FSH+LH na linhagem C57BL6 SCID. A termografia não permitiu a distinção entre os tecidos doador e receptor por ocasião do xenotransplante. Na avaliação das funções renais e hepáticas da bioquímica plasmática, apenas a ureia apresentou valores menores para animais transplantados quando comparados aos seus respectivos modelos controles. Conclui-se neste estudo que: a análise histológica permitiu o monitoramento da reperfusão e desenvolvimento folicular do transplante; novos protocolos hormonais devem ser testados para a obtenção de oócitos aptos para fertilização; a termografia infravermelha forneceu precisão para o monitoramento dos ovários doadores e o rim dos receptores, não evidenciando os transplantes; os animais C57BL6 SCID são mais indicados para o procedimento cirúrgico quando comparados aos BALB/c Nude e que o xenotransplante sob a cápsula renal não compromete as funções renal e hepática do animal receptor.
Synthesis of a Conjugate of Gossypol with Doxorubicin
Authors: Stepanov Andrey V. , Krayushkin Mikhail M. , Tretyakov Evgeny V. , Ilyushenkova Valentina V. , Shchekotikhin Andrey E. , Akchurin Igor O. , Dezhenkova Lyubov G. , Yarovenko Vladimir N.
Published: January 2025

Gossypol has been shown to be a promising natural product for the anticancer drug development for
treating leukemia, lymphoma, colon carcinoma, breast cancer, and other malignant disease. It is known that the
conversion of aldehyde groups of gossypol into iminofragments by the treatment of various amines can reduce
the toxicity of the derivative and simultaneously increase their pharmacological efficacy. This article describes
the preparation and screening of antiproliferative properties of a conjugate of gossypol with antitumor antibiotic doxorubicin. It has been shown that the reaction of the amino group of doxorubicin with the aldehyde
groups of gossypol gives the condensation product in which two pharmacophores are linked via enamine–
enamine moieties. However, this conjugation decreased the antiproliferative activity of paternal doxorubicin
and gossypol against chronic myeloid leukemia cells K562 and led to dramatic loss of potency against MDRsubline K-562/4 with expression of Р-glycoprotein (Р-gp).
Hallmarks of Quercetin Benefits as a Functional Supplementary in the Management of Diabetes Mellitus-Related Maladies: From Basic to Clinical
Applications
Authors: Farhadi Faegheh , Sharififar Fariba , Jafari Mandana , Rahimi Vafa Baradaran , Askari Nafiseh , Askari Vahid Reza
Published: January 2025

Quercetin (QE), a particular flavonoid, is well known for its medicinal effects, including anti-oxidant,
hypoglycemic, and anti-inflammatory effects. In this review, the findings of QE effects on diabetes STZinduced,
alloxan-induced, and its complications have been summarized with a particular focus on in vitro, in vivo,
and clinical trials. Consequently, QE mediates several mechanisms, including ameliorating tumor necrosis
factor (TNF)-α, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), interleukin (IL)-1β,
IL-8, and IL-10 expression, increasing insulin glucose uptake to inhibit insulin resistance. Moreover, QE stimulates
insulin secretion and attenuates insulin resistance through various pathways, namely transient KATP channel,
motivating peroxisome proliferator-activated receptor expression, increasing glucose transporter-4, and decreasing
inducible nitric oxide synthase in skeletal muscle. QE has protective effects on the complications
caused by diabetes, such as polycystic ovary syndrome, high-fat diet-induced obesity, diabetic-induced hepatic
damage, vascular inflammation, nephropathy, and neuropathy.
Precision Medicine in Colorectal Cancer: Targeted Therapies and Biomarker Insights
Authors: Srivastava Shriyansh , Anand Amit , Kandhula Anil Goud , Jaiswal Pooja , Kumar Sachin , Gulati Monica , Sachdeva Monika , Behl Tapan
Published: January 2025

The current review delves into the transformative role of precision medicine in addressing Colorectal Cancer [CRC], a pressing global health challenge. It examines closely signalling pathways, genetic and epigenetic modifications, and microsatellite in-stability. The primary focus is on elucidating biomarkers revolutionizing CRC diagnosis and treatment. Genetic biomarkers encompass non-coding RNA, epigenetic markers, TP53 mutations, and KRAS, NRAS, and BRAF gene alterations. Targeted therapies, including anti-EGFR, anti-VEGF, immune checkpoint inhibitors, and HER2-targeted treatments, are explored along with their mechanisms and clinical applications. Additionally, we highlight the importance of utilizing personalized treatment strategies by employing molecular pro-filing and genetic testing. These approaches facilitate the identification of appropriate pa-tients for targeted therapies. Clinical trials supporting these treatments are presented, em-phasizing response rates and survival outcomes. Detailed exploration of resistance mecha-nisms to targeted therapies and strategies to overcome resistance is also provided, paving the way for more effective regimens. Directions for future research in precision medicine, such as biomarkers, combinations, and liquid biopsy in the oncology field, are described. However, the precise application of precision medicine in CRC comes with questions such as costs, considerations of ethical factors, and the need to sensitize patients. Nonetheless, based on a meticulous analysis of several aspects, precision medicine finds itself equipped with the ability to enhance the patients’ prognosis ,thereby, lessening the global oncologic burden of CRC and provide important information to the clinician-scientist and policy-maker that might benefit from the ongoing development of precision medicine.
A New Recyclable Yttrium-Catalyzed Domino Three-Component
Approach to the Synthesis of 3-Methyl-4 arylmethylene Isoxazol-5(4H)-ones
Authors: Ilaamirthamani Simsonrubarathinam , Kumarraja Mayilvasagam
Published: January 2025

In this study, a domino multicomponent strategy was followed for the cyclo condensation
reaction of aldehydes with β-ketoesters and hydroxylamine hydrochloride to produce a variety of 3,4-
disubstituted isoxazol-5(4H)-ones using a novel Yttrium (III)-MMZ catalyst. Aprotic polar solvents
and hard Lewis acid metal ions were found to greatly influence the reaction. In this study, the effect
of the Y3+ in the MMZ framework and the nature of substrates and their positions in determining the
yield of products were also described, along with a supporting mechanism. The structural morphology of Y3+-MMZ was characterized by the electron microscopic technique, and the loading level of
Y3+ ions was determined by EDAX analysis. Most of the experiments did not require further purification by column chromatography. The present catalytic method offers several other advantages over
the other reported methods, such as easy preparation, recyclization of the catalyst (up to 3 times),
mild reaction conditions, shorter reaction time, and ease of work-up on recovering the products.
Reported Postoperative Surgical Site Infections in Tertiary Care Hospitals,
Systematic Review of Recent Literature
Authors: Nadeem Soam , Hameed Afra Abdul , Gillani Syed Wasif , Rathore Hassan Anwer
Published: January 2025

Purpose:

The objective of this systematic review is to evaluate the patterns of postsurgical site infections, pre-surgical antibiotics prophylaxis, and related clinical outcomes in the
recently published literature.

Methods:

This systematic review is registered with PROSPERO registration number
CRD42023398963. Several databases and individual journal websites were used to collect data
from PubMed/Medline, TRIP, SCOPUS, Elsevier, Springer, ProQuest, and EMBASE. The established criteria of inclusion were RCTs, retrospective, prospective, and cross-sectional studies
with patients who had a recent surgical procedure. Excluded from the study designs were systematic reviews, prospective studies, data on pediatrics, and data on disabilities. Quality assessment analysis of the results for randomized controlled trials (RCT) used CONSORT guidelines and STROBE guidelines for cross-sectional and cohort studies.

Results:

A total of 328 articles were identified from different databases. Among them, 15 studies were included for data extraction and qualitative analysis. A total of 33,193 patients with an
average rate of 11.5% (surgical site infections- SSIs) were identified in these studies during
2008-2022. The mean rate of SSIs among the total number of immunocompromised patients/procedures was 10.2%. The SSI on patients undergoing major surgical procedures with
visible incisions was 26.0%. The majority of the studies reported the use of pre-surgical antibiotic prophylaxis. Cefazolin was mostly prescribed antibiotics and administered in 90% of patients. Other antibiotics included ceftriaxone (4%), cloxacillin (3%), and vancomycin (4%). The
mean reported rate of SSIs with combination antibiotic prophylaxis therapy was 22.8%.

Conclusion:

This systematic review concluded the limited reported data on surgical site infections (SSIs). The overuse of pre-surgical antibiotic prophylaxis has been reported in several
studies. This study recommended developing standardized guidelines on the use of antibiotics
related to surgical cases rather than co-morbidities
Tissue Plasminogen Activator for COVID-19-induced Severe Acute
Respiratory Distress Syndrome: A Controlled Clinical Trial
Authors: Naderpour Zeinab , Aliannejad Rasoul , Mehrtash Vahid , Mollazadeh Reza , Hosseini Seyedeh-Esmat , Amini Shahideh , Pak Neda , Motlaq Tahereh Madani , Khodaei Behzad , Jafarzadeh Bita , Habibi Reza , Madreseh Elham , Vasei Mohammad , Solaymani-Dodaran Masoud
Published: January 2025

Objective:

This study aimed to assess the safety and efficacy of tissue Plasminogen Activator (tPA) in patients with COVID-19-induced severe Acute Respiratory Distress Syndrome (ARDS).

Methods:

The intervention group consisted of eligible patients with severe ARDS due to COVID-19
admitted to the Intensive Care Unit (ICU) of a university hospital. We selected the control group from
admitted patients treated in the same ICU within the same period. The intervention group received
intravenous tPA as 10 mg stat, 40 mg over the first 2 hours, and 25-50 mg over the next 10 hours,
followed by a therapeutic dose of enoxaparin. The control group only received the therapeutic dose of
enoxaparin. The main outcomes were the rise of SpO2 within 24 hours of tPA administration, critical
bleeding during tPA administration, 28-day in-hospital mortality following admission to the ICU, and
length of stay in the ICU.

Results:

We analyzed two sets of 15 patients in the intervention (mean age: 45 years, 69% male) and
the control (mean age: 50 years, 50% male) groups. There was rapid relief of dyspnea and SpO2 rising
within 24 hours in seven cases (45%) only in the intervention group with no significant organ-threatening bleeding. Death was observed in 5 of the tPA-treated patients (33.3%) versus 10 (66.7%) of the
controls [adjusted OR (95%CI): 0.17 (0.03, 0.98), P value =0.068].

Conclusion:

The administration of intravenous tPA as 10mg stat, 40 mg during 2 hours, and 50mg
during the next 10 hours is safe, can cause a rapid relief of dyspnea, and be lifesaving
Phosphodiesterase Inhibitors: A Therapeutic Approach for ArsenicInduced Neurotoxicity
Authors: Bhatt Sonia , Singh Ajay Pal , Kumar Sokindra
Published: January 2025

Introduction:

One of the world's most serious health issues is arsenic toxicity. Prolonged consumption of Arsenic contaminated water causes cognitive damage in the developing and adult brain. The present research investigated how sodium arsenite-induced neurotoxicity in SD rats was affected by rolipram, a PDE4 inhibitor, and vinpocetine, a PDE1 inhibitor.

Methods:

The arsenic concentration was determined, which indicates the accumulation of arsenic in blood. The low weight of the brain indicates the adverse effects on the brain, which
was significantly improved by rolipram and vinpocetine. Biochemical markers (MDA, GSH,
CAT, and SOD) and protein expression of CREB and P-CREB were studied in the hippocampal region of the brain.

Results:

The reduced antioxidant activity and elevated levels of inflammation were significantly improved by rolipram and vinpocetine administration. Additionally, rolipram and
vinpocetine significantly increased the CREB and P-CREB expression in the hippocampi of
rat brains.

Conclusion:

PDE4 and PDE1 inhibition in arsenic-induced neurotoxicity could be a novel approach and a new drug therapy for arsenic-induced neurotoxicity.
La imposibilidad e ilegalidad del uso de la fuerza en Corea del Norte en el gobierno Bush (2001-2006) como opción para resolver la crisis nuclear norcoreana
Authors: Torres Rojas Gloria Milena
Published: January 2025

La cuestión nuclear de Corea del Norte, que sigue sin resolverse desde la primera crisis nuclear, surgió en 1994.  A pesar de que se han hecho esfuerzos para resolver la crisis, hasta ahora el impasse nuclear no se ha resuelto totalmente. El estudio busca demostrar que cualquier uso de la fuerza en Corea del Norte traería riesgos políticos, militares y en el derecho internacional, razones por las cuales ha sido descartada como opción para Estados Unidos.
La importancia de este estudio consiste en evidenciar que el uso de la fuerza en Corea del Norte tiene límites, dadas las implicaciones y riesgos de esta política, especialmente para Estados Unidos, Corea del Sur, Japón, China y Rusia. La metodología es de índole cualitativa porque recurre a descripciones y análisis del objeto de estudio. Este trabajo se divide en cinco partes: en la primera se discutirá la diferencia entre Preemption y Prevención.  En la segunda, las implicaciones militares que cualquier eventual uso de la fuerza en la RPC tendría para los vecinos de Estados Unidos y Corea del Norte. En la tercera parte, se considerarán los riesgos políticos del uso de la fuerza En la  cuarta sección se discutirán las implicaciones para el derecho internacional, y en la sección final se expondrán las conclusiones.
A framework for blockchain-based management of IoT-driven data sharing
Authors:   College of Computer Science and Engineering, University of Ha’il, Ha’il, Saudi Arabia, Alreshidi Abdulrahman
Published: January 2025

Big data systems rely on acquiring, analyzing, and processing diverse data sets to enable predictive analytics in decision support systems. The integration of Internet of Things (IoT) devices generates vast amounts of data, creating challenges related to security, scalability, and efficient data management in mobile environments. Traditional IoT data sharing platforms often depend on Trusted Third Parties (TTPs), which compromise security, transparency, and trust, while also facing constraints like limited storage, privacy concerns, and high energy consumption. This research proposes a blockchain-based IoT data management platform utilizing the InterPlanetary File System (IPFS) to address these issues. The platform defines data access roles through smart contracts, ensuring data integrity and security while modernizing legacy systems. Experimental evaluation demonstrates the platform's efficiency in energy consumption and storage management for smart communication contracts. Key contributions include a blockchain-based architecture, algorithms for implementation, and validation using satellite-sensed data, advancing decentralized data management solutions.
The Mediating Role of Meaning-Making in the Relationship Between Mental Time Travel and Positive Emotions in Stress-Related Blogs: Big Data Text Analysis Research
Authors: Chen Yidi , Zheng Lei , Ma Jinjin , Zhu Huanya , Gan Yiqun
Published: January 2025

Background

Given the ubiquity of stress, a key focus of stress research is exploring how to better coexist with stress.

Objective

This study conducted text analysis on stress-related Weibo posts using a web crawler to investigate whether these posts contained positive emotions, as well as elements of mental time travel and meaning-making. A mediation model of mental time travel, meaning-making, and positive emotions was constructed to examine whether meaning-making triggered by mental time travel can foster positive emotions under stress.

Methods

Using Python 3.8, the original public data from active Weibo users were crawled, yielding 331,711 stress-related posts. To avoid false positives, these posts were randomly divided into two large samples for cross-validation (sample 1: n=165,374; sample 2: n=166,337). Google’s natural language processing application programming interface was used for word segmentation, followed by text and mediation analysis using the Chinese psychological analysis system “Wenxin.” A mini–meta-analysis of the mediation path coefficients was conducted. Text analysis identified mental time travel words, meaning-making words, and positive emotion words in stress-related posts.

Results

The constructed mediation model of mental time travel words (time words), meaning-making words (causal and insightful words), and positive poststress emotions validated positive adaptation following stress. A mini–meta-analysis of two different mediation models constructed in the two subsamples indicated a stable mediation effect across the 2 random subsamples. The combined effect size (B) obtained was .013 (SE 0.003, 95% CI 0.007-0.018; P<.001), demonstrating that meaning-making triggered by mental time travel in stress-related blog posts can predict positive emotions under stress.

Conclusions

Individuals can adapt positively to stress by engaging in meaning-making processes that are triggered by mental time travel and reflected in their social media posts. The study’s mediation model confirmed that mental time travel leads to meaning-making, which fosters positive emotional responses to stress. Mental time travel serves as a psychological strategy to facilitate positive adaptation to stressful situations.
TERF Intimate Publics
Authors: Church Jo
Published: January 2025

This article asks: how does trans-exclusionary radical feminism (TERFism) function to create an intimate public that generates a sense of belonging along gendered and racialized lines? Drawing from Judith Butler, I use “fascism” as a conceptual frame while analyzing online images and sentiments of a trans-exclusionary radical feminist (TERF) who belongs to an Australian anti-gender Facebook group. I argue that TERF intimate publics are constituted by feelings of loss and resentment which become alleviated through claiming legitimacy along a “natural” gendered and racialized hierarchy of human worth, through demanding a return of one’s “sex-based rights,” and through a commitment to victimhood. Generating pride in a perceived endangered identity, this article finds that TERF intimate publics uphold the regulatory norms of cis-heteronormativity and whiteness. This analysis reveals that they offer a space for racist nationalism rooted in cis-hetero-misogyny, a crucial finding as TERFism gains traction in the current political moment.
Analyzing the Impact of Over Speeding of the Vehicles in the Society
Authors: Sawwashere Dr. S. S.
Published: January 2025

Over-speeding is a leading cause of business accidents, performing in significant losses and severe injuries worldwide.
According to WHO, speed is a contributing factor in roughly 30 of road deaths in high- income countries and nearly 50 in lowand middle- income countries. Controlling vehicle speed is pivotal to precluding crashes and minimizing the inflexibility of
injuries. Traditional styles of speed control and business law enforcement are frequently shy in effectively managing and
reducing over-speeding incidents. To address this issue, recent studies have explored colorful technological results, similar as the
Automatic E-Challan System, IOT- grounded business violation systems, and RF- grounded vehicle discovery. These systems use
advanced technologies like detector networks, image processing, and radio frequence to cover business, descry violations, and
issue penalties automatically. These approaches aim to enhance enforcement effectiveness, ameliorate business operation, and
reduce road accidents. Our exploration focuses on integrating an automated speed discovery system that not only cautions
motorists when they exceed speed limits but also contributes to reducing road accidents by administering compliance with
business regulations. This result is anticipated to ameliorate road safety by precluding over-speeding and icing timely
interventions.