bluuebunny/crossref_metadata_2025 huggingface dataset:
The importance of multidisciplinary care of patients with Wolfram
Authors: Dennison Rebecca A
Published: October 2021

Background: Wolfram syndrome is a genetic condition, which is typically inherited in autosomal recessive fashion, characterized by the combination of diabetes mellitus and optic atrophy. It is along a spectrum which encompasses DIDMOAD (Diabetes insipidus, diabetes mellitus, optic atrophy, and deafness). Profound hypoglycemic unawareness can be seen in this condition but is not commonly described as an associated feature in the literature. Case report: A 16 year old female with history of presumed type 1 diabetes presented to urology clinic with urinary incontinence. She was found to have profound dilation of the bladder and was admitted for bladder decompression. During the course of admission she was found to also have diabetes insipidus and optic atrophy. She had several severe hypoglycemic episodes with profound hypoglycemia unawareness during this admission. Genetic testing for Wolfram syndrome was positive. As an outpatient she was placed on a continuous glucose monitor to help manage her hypoglycemia. Addtionally, psychiatric support to manage her associated depression was an important aspect of her therapy. As her depression improved so did her ability to comply with the necessary therapies. Conclusions: Wolfram syndrome is a rare syndrome that has been well described. However, patients with this syndrome have frequent hypoglycemia unawareness and severe hypoglycemia likely related to the neurologic deterioration that occurs at the molecular level in the pathogenesis of Wolfram syndrome. Strategies must be put in to place to help prevent and quickly treat these hypoglycemic events.
Sample of Aboriginal Australians, 2-hour post-load insulin concentrations are greatest between fasting plasma glucose values of 6.7-7.3 mmol/l
Authors: Aveyard Paul
Published: October 2021

Background: Prevention of diabetic complications requires good glycaemic control. This study aimed to provide type 2 diabetes patients with remote active care and glycaemic control through the use of videophone technology without the need for them to attend hospital. The literature recommends additional research to study the impact of technical innovations on improved disease self-management and medical outcome. This is the only study to be conducted in Turkey concerning patient monitoring using videophone technology. The aim of the study was to establish the effectiveness of the use of videophone technology in the glycaemic control of patients with diabetes living in remote areas. Methods: This is a prospective, randomized control study using the systematic sampling method (using half ratio), in which 24 patients were chosen for the Experimental Group (EG) and another 24 for the Control Group (CG). All of the patients agreed to participate in the study. Patients in the CG received routine care, while the glycaemic control and consultations for patients in the EG were conducted using videophone technology. The patients were monitored by videophone for a total of 6 months. The HbA1c and blood glucose values recorded over the 6 month monitoring period were analyzed to determine the effectiveness of using a videophone. Results: The mean age of the individuals in the EG was 54.41 ± 8.54 years (Min=43 Max=78) and in the CG it was 57.25 ± 9.61 (Min=40 Max=77). In both groups, 50% of the individuals were men and 50% were women. When the two groups were compared, it was was found that the preprandial blood glucose levels of the diabetic patients in the EG (mean 159.48 ± 40.71mg/dl) were lower by 13.55 ± 52.89 mg / dl than the preprandial blood glucose levels of the diabetic patients in the CG (mean 173.03 ± 65.07 mg/dl). It was determined at the end of the six-month monitoring that the A1c levels of the individuals in the EG were significinatly lowered by 0.49% in total, and that the A1c levels of the individuals in the CG were higher by 0.17 % in total. Conclusions: It was shown that videophone technology can be useful in the glycaemic control of diabetic patients in Turkey.
The Diabetes TRACK (by NEHEP) Vs Bangladesh
Authors: Mohiuddin Abdul Kader
Published: October 2021

With the increasing burden of non-communicable diseases in low-income and middle-income countries (LMICs), biological risk factors, such as hyperglycemia, are a major public health concern in Bangladesh. Optimization of diabetes management by positive lifestyle changes is urgently required for prevention of comorbidities and complications, which in turn will reduce the cost. Diabetes had 2 times more days of inpatient treatment, 1.3 times more outpatient visits, and nearly 10 times more medications than non- diabetes patients, as reported by British Medical Journal. And surprisingly, 80% of people with this so called “Rich Man's Disease” live in low- and middle-income countries. According to a recent study of American Medical Association, China and India collectively are home of nearly 110 million diabetic patients. The prevalence of diabetes in this region is projected to increase by 71% by 2035. Bangladesh was ranked as the 8th highest diabetic populous country in the time period of 2010-2011. In Bangladesh, the estimated prevalence of diabetes among adults was 9.7% in 2011 and the number is projected to be 13.7 million by 2045. The cost of diabetes care is considerably high in Bangladesh, and it is primarily driven by the medicine and hospitalization costs. According to Bangladesh Bureau of Statistics, in 2017 the annual average cost per T2DM was $864.7, which is 52% of per capita GDP of Bangladesh and 9.8 times higher than the general health care cost. Medicine is the highest source of direct cost (around 85%) for patients without hospitalization. The private and public financing of diabetes treatment will be severely constrained in near future, representing a health threat for the Bangladeshi population.
Waste Heat Recovery from Servers Using an Air to Water Heat Pump
Authors: Lipiński Seweryn , Duda Michał , Górski Dominik
Published: October 2021

The analysis of advisability and profitability of using an air to water heat pump for the purpose of waste heat recovery from servers being used as cryptocurrency mining rigs, was performed. To carry out such an analysis, the cooling unit of the computing server was connected to the heat pump, and the entire system was adequately equipped with devices measuring parameters of the process. Performed experiments proves that the heat pump coefficient of performance (COP) reaches satisfactory values (i.e., an average of 4.21), what is the result of stable and high-temperature source of heat at the pump inlet (i.e., in the range of 29.9-34.1). Economic analysis shows a significant reduction in the cost of heating domestic hot water (by nearly 59-61%). The main conclusion which can be drawn from the paper, is that in a case of having a waste heat source in a form of a server or similar, it is advisable to consider the purchase of air-to-water heat pump for the purpose of domestic hot water heating.
Bootstrap Aggregation Technique for Evaluating the Significance of Manufacturing Process Parameters in the Glass Industry
Authors: Paśko Łukasz , Kuś Aneta
Published: October 2021

The article presents the application of the bootstrap aggregation technique to create a set of artificial neural networks (multilayer perceptron). The task of the set of neural networks is to predict the number of defective products on the basis of values of manufacturing process parameters, and to determine how the manufacturing process parameters affect the prediction result. For this purpose, four methods of determining the significance of the manufacturing process parameters have been proposed. These methods are based on the analysis of connection weights between neurons and the examination of prediction error generated by neural networks. The proposed methods take into account the fact that not a single neural network is used, but the set of networks. The article presents the research methodology as well as the results obtained for real data that come from a glassworks company and concern a production process of glass packaging. As a result of the research, it was found that it is justified to use a set of neural networks to predict the number of defective products in the glass industry, and besides, the significance of the manufacturing process parameters in the glassworks company was established using the developed set of neural networks.
The Embassy of Pyotr Potemkin to Spain, 1667–1668: Some Features of Mutual Perception and Dialogue of Two Diplomacies
Authors: Védyushkin Vladimir
Published: October 2021

The Russian diplomacy of the 17th century had some specific features in comparison with the Western European diplomacy of the same time. The purpose of this article is to identify these features and analyze the perception of Russian ambassadors by European diplomats. The research is based on both Russian and Spanish documentation of the embassy of Piotr Potemkin (1667–1668), the first Russian embassy in Spain. Since there were no instances of diplomatic contacts between the two countries in the past, the diplomatic ceremonial was of crucial importance for P. Potemkin’s mission. Since no contact between the diplomats and the Ambassadorial Chancellery in Moscow was not possible due to the long distance between Russia and Spain, the detailed instructions (nakaz) given to P. Potemkin in Moscow acquired a special significance. Therefore the article aims to determine the extent and nature of the dependence of the diplomats’ actions on their instructions. A comparative analysis of the nakaz and the final report (stateinyi spisok) in the part related to the stay of the embassy in Madrid and the negotiation process shows that the ambassadors scrupulously observed the nakaz, taking initiative only in those cases that were not covered by it. All of its requirements had a logical explanation: not to harm the interests of Russia, not to lower the honour of the envoys of a great power, not to create a bad precedent in the diplomatic ceremonial. The Spanish side, not sufficiently aware of the specifics of the nakaz, sometimes did not understand the behaviour of the ambassadors, attributing it to their vanity, pettiness, and bad temper. At the same time, although the Russian embassy took Spanish diplomats wholly by surprise, the latter managed, within a limited time, to collect a variety of information about the Russians and take it into account, showing flexibility in organizing audiences and during negotiations. Although there were differences between Spanish and Russian diplomats, both sides adhered to European diplomatic practice. The absence of contradictions between the two states and their interest in establishing diplomatic relations and developing bilateral trade determined the success of P. Potemkin’s embassy.
Embassy of the Russian Empire in Berlin on the Socialist Movement in Germany in 1890–1898
Authors: Matveeva Anna
Published: October 2021

The study focuses on assessing the representativeness and relevance of diplomatic documents for the study of key aspects of German domestic politics. Three issues are central to the analysis of the documents from the Archive of the Foreign Policy of the Russian Empire: the completeness of the indicated sources for understanding the factors of the German Empire’s inner policy; the assessment of the subjectivity of the author of diplomatic dispatches, i.e. how much the ambassador's personality determined the content of the dispatches that he sent to the ministry; the relevance of highlighting key issues of internal life in Germany from the point of view of Russian diplomats. Among constantly present in the messages, the most important was the problem of the socialist movement and the Social-Democratic Party’s activities. The socialists were mentioned for significant reasons: the repeal of the Law against the Socialists, the Berlin Conference on the Labor Protection (1890); elections to the Reichstag (1893, 1898); the Reichstag votes on issues important for Russia. The measures of counteraction to the socialists, discussed by the emperor and the government, also aroused interest. The study of archival documents (1890–1898) allows the author to draw the following conclusions. The dispatches adequately reflect the main trends in the socialist movement and the tactics of the SPD, therefore they can be used to study many internal problems faced by Germany in the course of its political evolution. The development of the social-democratic movement was rightly interpreted by Russian diplomats as one of the fundamental reasons for the internal instability of the German state during the reign of Wilhelm II. At the same time, the conclusion drawn by the diplomats can be primarily explained by the Russian imperial regime and its substantial characteristics, rather than the political realities within Germany itself. They considered parliamentarism, limiting the monarch actions (the state interests), to be the main reason for the high popularity and the broadest electoral support of the SPD. The key factor preventing the monarch from defeating the “coup parties” was defined as the activities of liberal political parties, which demanded the unconditional observance of the freedoms prescribed in the Сonstitution of 1871, as well as the prevention of the introduction of Exceptional Laws and other measures of an extraordinary nature.
A közösségi média archiválásának nehézségei
Authors: Drótos László
Published: October 2021

Web 2.0 sites designed for user-uploaded textual and audiovisual content began to grow exponentially in the 2000s, and today they have become the most important communication channels for culture and public life, beyond the sharing of private information targeted at a narrow audience. However, these platforms are even more “in present tense” than the traditional web. And this is not just about publicly published and then removed content, but about dozens of services with millions of users that have been discontinued for economic reasons, with gigabytes or terabytes of digital material disappeared overnight. Nowadays most social platforms are more optimized for mobile devices, and not archive-friendly at all, or even explicitly prevent downloading by automatic methods. This paper details the problems of their long-term preservation based on the tests carried out within the framework of the web archiving project in the National Széchényi Library, as well as international examples.
A könyvtári együttműködés informatikai támogatása: adatmodell, workflow, rendszerfelépítés: Együttműködési lehetőségek a nyílt forráskódú platformokban: OKP, FOLIO, ReShare
Authors: Lendvay Miklós
Published: October 2021

An essential goal of library informatics is to create open-source systems through community collaboration. Primary examples of open solution Integrated Library Systems, such as KOHA, Evergreen, or the Open Library Environment (Kuali OLE), have been born out of this notion. Since 2016, the librarian and developer professional communities have been working together to take this framework to a higher level. Building on learnings from prior system developments, a new modular, micro-service based platform was created. The platform was named FOLIO, short for ’The Future of Libraries is Open’, to reflect its open and flexible nature. Today, FOLIO platform and its relevant modules are widely used by a number of medium-sized and national libraries (e.g. the Italian National Library in Florence). The objectives of the Hungarian National Library Platform (HNLP) development, launched in 2016, are very much in alignment with the above: to re-conceptualise services offered by national libraries, to explore new ways of collaboration, to revolutionise common catalogue and interlibrary loan, and to make entity-based data connections available beyond the world outside libraries through integration to the Hungarian National Namespace. And first and foremost, to offer the most advanced services and state-of-the-art IT technology to library users. The National Széchényi Library Hungary has been part of the FOLIO community since its inception, to have a stake in its strategic direction and to benefit from the developments taking place internationally. Our long-term vision is to enable seamless module compatibility between the two systems so that libraries can use a flexible configuration that best serves their needs. The main pillars of the development are identical for both FOLIO and HNLP: (i) an entity-based data model, (ii) the creation of a meaning-based integrated architecture through modularity for any number of institutions and any institutional hierarchy, and (iii) the free configurability of workflows across the system / flexible workflow design. Where are HNLP, FOLIO and ReShare, the major collaborative module for interlibrary loan of the latter on this path right now? What solutions are provided for the basic pillars, and what objectives are still to be achieved?
Tömeges könyvtári felhasználóképzés távoktatási formában az SZTE Klebelsberg Könyvtár e-learning platformján
Authors: Várnai-Vígh Adrienn Erzsébet , Kokas Károly
Published: October 2021

MOOCs (Massive Open Online Courses) are one of today’s popular and effective educational solutions. This presentation connects directly to another, held by our colleagues. Last spring, we have managed to create a complete e-learning package with our team at the SZTE Klebelsberg Library in order to meet the unprecedented challenges during the pandemic. We have more than 10 years of experience from organizing the Introduction to library and information science compulsory course for the students of the Faculty of Humanities and Social Science, which means about 5-600 students per semester. In our presentation, we will share insights about our experiences managing the e-curriculum and the system of tools behind it: starting with the platform and the database of the exam questions, followed by the communication with the students and ending with the grading method. We will also address the initial extreme difficulties, emerging requests and evaluate the first year’s experiences as well.
Intézményi, támogatói szabályozások kialakítása a nyílt tudomány kutatási adatkezelési céljaihoz
Authors: Holl András
Published: October 2021

A nyílt tudomány (Open Science) kulcsterülete a kutatási adatok kezelése. Az immár a kutatási gyakorlat részévé vált nyílt hozzáférés (Open Access) tekintetében léteznek hazai szabályozások, továbbá rengeteg nemzetközi ajánlás is segíti ezek finomítását, bővítését, azonban a kutatási adatkezelés területén még előttünk áll a szabályozások kialakítása.
Komplex informatikai megoldás természettudományos ismeretek bemutatására az egri Varázstoronyban
Authors: Horváth Krisztián , Keller Zsófia , Oravecz Zsolt , Sass-Gyarmati Norbert , Geda Gábor
Published: October 2021

Magyarországon az 1970-es évek elején vette kezdetét a múzeumokban az a változás, melynek eredményeként a gyermek- és az ifjúsági korosztály kiemelt szerepet kapott. Célja a múzeumokban felhalmozott gyűjtemény és szellemi érték népszerűsítése az említett korosztályok számára. A fentieket alapul véve, azt tűztük ki célul, hogy az egri Természettudományos Pályaorientációs és Módszertani Központot választva, az ott működő Varázstorony eszközeit újítjuk meg, és ott alakítjuk ki az általunk tervezett és fejlesztett rendszert, egyben javaslatot téve a látogatási rend módosítására is. Egy olyan komplex hardver és szoftver rendszert hoztunk létre, melynek segítségével a látogatók a saját mobileszközük segítségével tudják bejárni és megismerni a Varázstorony épületét, kiállításait, valamint kísérleteket végezni olyan módon, hogy az arra alkalmas eszközöket például telefonjuk segítségével vezérlik.
A könyvtárak az új digitális világban
Authors: Csík Tibor
Published: October 2021

According to Umberto Eco, books share their fates with their readers. Carrying the idea forward, not only books but also libraries share their fates with their readers. The state of a society is well illustrated by the state of its libraries and how to access information resources. The aim of the presentation is to examine the impact of libraries and their services on the neoliberal economic environment and the expanding process of commodification. Nicholas Negroponte (MIT) stated in 2010 that the physical book will be dead in five years. Although his provocative forecast has not been confirmed, the ratio of online resources in the acquisition of libraries is increasing. Technology companies have approached libraries to digitize their printed collection. Then the digital contents were sold, or used in accordance with their commercial interests to expand the advertising network. Information companies offered e-journals in large bundles for sale to libraries. Despite their promise, the price of digital publications has not become cheaper, but prices have risen steadily. The economic crisis of the early 2000s led to the closure of many public libraries. However libraries cannot become an information soup kitchen, where equal access to data and information hides the fact that there is inequality in access to meaningful information or important knowledge. The tasks of teaching library is not only to teach library and research skills, navigation on web, information retrieval from databases and how acting a law-abiding information consumer. Libraries can teach about information production and current information economics in part of information literacy. Libraries play a role in electronic publishing through their digital collections and repositories.
Speciális dokumentumok és tartalmak – speciális metaadatszerkezetek Muzeális tartalmak és kéziratok repozitálása a Szegedi Tudományegyetem Klebelsberg Kuno Könyvtárában
Authors: Farkas Katalin , Nagy Dóra
Published: October 2021

At the beginning of the 2020s, the SZTE Klebelsberg Library will need to store the digitised museum documents and manuscript legacies that have been and are still being generated in a repository. The content was placed in the library’s thematic EPrints software-based repository Miscellanea. Different types of documents required different solutions, and their metadata required the development of a different metadata form. A solution was needed to create a structured structure in the repository to house the digital versions of the paper documents in the collection and the content transferred for digital preservation. The task was to define the different levels of access, the ongoing cleaning of the data and the establishment of the catalogue-repository link. The report presents possible solutions to these problems.
Szöveghasonlósági vizsgálatok automatizálása
Authors: Kiss Margit , Palkó Gábor , Szakács Béla Benedek
Published: October 2021

A stilometriai elemzések a digitális bölcsészeti kutatásokban központi szerepet töltenek be: a szövegalkotás egyéni jellemzőinek a feltárásában segítenek úgy, hogy a meghatározó jegyek kiszűrése révén tulajdonságok tízezrei alapján hasonlíthatók össze a kérdéses szövegek. E számítógéppel végzett összetett statisztikai elemzőeljárások elvégzése közel sem egyszerű művelet. Különféle elemzőszoftverek (Websty, JGAAP, Stylene stb.) érhetők ma már el, azonban azt a feladatot, amely a megfelelő elemzési eredmények eléréséhez szükséges, a felhasználónak komoly nyelvészeti-statisztikai háttértudással és empirikus kísérletek révén kell elvégeznie.
Klassiker der Strategie – eine Bewertung
Authors: Stahel Albert A.
Published: October 2021

Nach dem Ende des kalten Krieges und dem Zusammenbruch der Sowjetunion glaubte man, die Zeit der Konfrontationen sei vorbei. Diese Hoffnung erweist sich heute angesichts der vielen regionalen Konflikte als falsch. Das Ende des kalten Krieges mag das Ende der grossen Konfrontationen und damit der grossen Kriege bewirkt haben, lokale Auseinandersetzungen resp. die "kleinen Kriege" sowie die klassische Machtpolitik der Grossmächte werden aber dadurch nicht verhindert. Mit den neuen Entwicklungen gewinnt die Strategie als die Wissenschaft der Kriegsführung wieder an Interesse. Die Strategie der politischen, wirtschaftlichen und militärischen Bewältigung kleiner Konflikte und Kriege wird künftig zunehmende Bedeutung erlangen. Ausgehend von einer systematischen Darstellung der Klassiker der Strategie (Sun Tzu, Machiavelli, Clausewitz, Liddell Hart) zeigt der Autor, dass deren Konzepte wichtige Impulse für die Lösung aktueller Probleme geben können.
„Du solltest es besser haben …“ – zur Intersektionalität von sozialer Mobilität, Generation und Geschlecht im Kontext von Migrationsfamilien
Authors: Ruokonen-Engler Minna-Kristiina
Published: October 2021

In meinem Beitrag setze ich mich mit der Frage auseinander, wie sich soziale Mobilitätsprozesse im Kontext von Migrationsfamilien gestalten. Ich frage, inwieweit Migration mit einem sozialen Mobilitätsprozess einhergeht und in welchem Zusammenhang dieser mit den familialen Generations- und Geschlechterverhältnissen steht. Dabei diskutiere ich familiale, soziale Mobilitätserfahrungen unter der Berücksichtigung von intergenerationalen Binnendynamiken sowie deren mögliche vergeschlechtlichte Ausprägungen anhand von zwei biografischen Fallvignetten. Ich beziehe mich dabei auf empirisches Material aus meiner Forschung zu Bildungsbiografien von Studierenden mit Migrationsgeschichte. Es handelt sich um eine qualitativrekonstruktive Studie, die sich aus einer biografieanalytischen, habitussensiblen Perspektive mit den Erzählungen von Universitätsstudierenden auseinandersetzt. Theoretisch verknüpfe ich in meiner Diskussion intersektionale und biografische Perspektiven mit sozialer Mobilität und Migration, Adoleszenz und Generationenverhältnissen.
D like Day- and Dream-Job. Eine explorative Untersuchung zu ambivalenten Aushandlungsprozessen sozialer Mobilität auf Instagram
Authors: Amsler Claudia , Amacker Michèle
Published: October 2021

Soziale Mobilität wird aktuell vermehrt diskutiert, sowohl im Rahmen wissenschaftlicher Studien als auch auf digitalen Plattformen wie Instagram. Hier sind neue, un(ter)bezahlte Arbeitsorte entstanden, die stark flexibilisiert und prekarisiert sind. Zudem teilen sie eine zentrale Eigenschaft mit anderen feminisierten Tätigkeiten wie jene der Care-Arbeit: Sie ist weitgehend unsichtbar, wobei die Subjekte selbst hypervisibel sind. Der Beitrag untersucht anhand von cyberethnografischem Material Aushandlungsprozesse sozialer Mobilität von Instragram-Influencer*innen, die kritische Bildungsarbeit im Bereich der sozialen Gerechtigkeit leisten. Dabei wurde von der Annahme ausgegangen, dass soziale Mobilität ein wiederkehrendes Thema in Beiträgen dieser Influencer*innen ist, da der soziale Status dieser Arbeit uneindeutig ist. Die explorative Analyse zeigt insbesondere die Bedeutung horizontaler Mobilität für Influencer*innen, wodurch gängige meritokratische Diskurse über eine vertikale Mobilität neu betrachtet werden können.
Verhandlungen von sozialer Mobilität und Biografie in postmigrantischen Gesellschaften
Authors: Völker Susanne
Published: October 2021

Ausgangspunkt der Sichtung von Theoretisierungen, Befunden und Erfahrungen zum Zusammenhang von sozialer Mobilität und biografischen Konstruktionen ist die These, dass sich mit der Prekarisierung und der Transnationalisierung von Lebensführungen in westeuropäischen Gesellschaften die Konzepte von sozialer Mobilität und Biografie substanziell verschieben. Im Beitrag werden aktuelle Forschungen zu transnationalen Biografien und Fluchtmigration aufgegriffen, um Impulse aus den raumzeitlichen Konstellationen der postmigrantischen Gesellschaft für den Zusammenhang von sozialer Mobilität und Biografie aufzunehmen. Schauplatz aktueller Verhandlungen um soziale Mobilität ist auch die Universität, an der heterogen situierte Studierende mit ihren Fragestellungen universitäre Methodenausbildung herausfordern und neu ausrichten.
Study of iron content in iron ore concentrate increasing effect on sintering process indices and on metallurgical properties of sinter
Authors: Isaenko G. E. , Kovalev D. A. , Meshcheryakov N. S. , Mikhailov V. G. , Kim D. S.
Published: October 2021

Effectiveness of blast furnaces operation in many respects depends on metallurgical properties of agglomerate, in particular, iron content in the sinter and its basicity. At the same time, it is accepted that usage of iron ore concentrates with iron content more than 66–67% for sinter production results in decreasing of its strength. As a result of the planned modernization of the technological sections of the concentration plant JSC “Stoilensky GOK”, iron content in the concentrate will be increased to 68–70%. It makes it actual to accomplish comprehensive studies of metallurgical properties of the sinter while increasing iron content in the raw material. Results of the study of sinter properties presented, the sinter being obtained with utilization of iron concentrate with iron content 66.6 % (base), 68.0 and 69.2 % (exp. 1 and exp. 2 correspondently). The iron ore mixture for all the stages was the same and consisted of iron ore concentrate – 78.3%, sintering ore – 8.0%, lime – 5.5% and sintering additives (sludge, dust, scale) – 8.2%. The sintering mixtures composition for all the study stages differed only by fluxes and iron ore mixture consumption. 18 test sintering operations at three values of basicity 1.6, 1.8 and 2.0 units were accomplished. It was established that increase of iron content in the concentrate and basicity of the sinter results in improving of the sintering process indices, increase of the vertical sintering rate, sintering machines productivity, recovery and the sinter cold strength. Increase of the sinter basicity and its production with increased content of iron results in improving RDI indices at low temperature reducing. Results of the study of porosity indices and metallurgical properties of the sinter presented, in particular the collapsibility during reducing and temperature interval softening-melting presented. The advisability of concentrate with increased iron content utilization in the iron ore mixture shown.
An automated system development to control the device for supplying slag-forming mixture into mould of CCM
Authors: Litsin K. V. , Utyamishev D. M.
Published: October 2021

The mechanism of feeding slag-forming mixture (SFM) with a pneumatic drive has a number of disadvantages associated, in particular, with the uneven supply of the mixture into mould. To eliminate the drawbacks, mixture feeding device with an electric drive was designed to eliminate them. In order to ensure control of the SFM feeding process, an automated system has been developed that provides real-time information on the technological process of feeding the mixture into the mould of continuous casting machine, including speed of rotation of screw drive motors and movement of carriage, the level of the mixture in the bunkers and its consumption, temperature of the metal and slag. A software and hardware complex (SCADA-system) has been developed, which makes it possible to analyze the components of the mixture in the “online” mode and take into account the effect of changes in the supply of each of them on its composition. The dependence of the mixture consumption rate on the casting rate has been established, which can be displayed on the screen in the current mode. Application of the SCADA-system made it possible to control the developed SFM feeder both in manual and automatic modes. It was shown that the implementation of the developed automated SFM feeding device in the steelmaking production of Ural Steel, JSC will secure decreasing the SFM consumption by 2.8% and decreasing downtime by 5% due to increasing efficiency of fault detection with a total implementation cost of 200 thous. rubles.
Experience of using a systemic glucocorticosteroid as an initial therapy for post-COVID-19 arthritis in outpatient practice
Authors:   Tver State Medical University, Tver, Russian Federation, Yershov V.E. ,   City Clinical Hospital No. 1 named after V.V. Uspensky, Tver, Russian Federation, Krivova A.V. ,   Tver State Medical University, Tver, Russian Federation, Zakharov V.P. ,   Tver State Medical University, Tver, Russian Federation, Bystrov S.V. ,   Tver State Medical University, Tver, Russian Federation,   City Clinical Hospital No. 1 named after V.V. Uspensky, Tver, Russian Federation
Published: October 2021

Amid the COVID-19 pandemic, a large number of patients with joint lesions resistant to nonsteroidal anti-inflammatory drugs (NSAIDs) was encountered in our clinical practice. The article summarizes the positive experience of outpatient therapy of 916 patients (mean age 47.1±11.3 years), including 774 women, with arthritis of various localization, which occurred on average 45.0±7.1 days after a previously transmitted infection caused by SARS-CoV-2. 709 (77.4%) patients used NSAIDs before going to the clinic, the effect of which was absent or insufficient. In this regard, intramuscular injections of betamethasone prescribed to 823 patients were used as the initial therapy (considering the comorbid background and allergy history). During the drug intake, most of the patients had relief of inflammation, pain reduction, improvement of the disease segment function already on the 7th day. In 69.3% of cases, a single-dose administration was sufficient. The obtained results allow drawing preliminary conclusions about the feasibility of using this technique in the complex treatment of reactive arthritis after the SARS-CoV-2 infection. KEYWORDS: coronavirus infection, COVID-19, glucocorticosteroids, nonsteroidal anti-inflammatory drugs, reactive arthritis. FOR CITATION: Yershov V.E., Krivova A.V., Zakharov V.P., Bystrov S.V. Experience of using a systemic glucocorticosteroid as an initial therapy for post-COVID-19 arthritis in outpatient practice. Russian Medical Inquiry. 2021;5(5):252–256 (in Russ.). DOI: 10.32364/2587- 6821-2021-5-5-252-256.
Secukinumab for non-radiographic axial spondyloarthritis
Authors:   North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg, Russian Federation, Gaydukova I.Z. ,   Clinical Rheumatological Hospital No. 25, Saint-Petersburg, Russian Federation, Mazurov V.I. ,   North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg, Russian Federation,   Clinical Rheumatological Hospital No. 25, Saint-Petersburg, Russian Federation, Inamova O.V. ,   North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg, Russian Federation,   Clinical Rheumatological Hospital No. 25, Saint-Petersburg, Russian Federation
Published: October 2021

Since 2009, the concepts of axial spondyloarthritis (axSpA) and peripheral spondyloarthritis (pSpA) have been used, while the radiographic phenotype (r-axSpA) and the non-radiographic phenotype (nr-axSpA) are distinguished. Nowadays, the treatment of nr-axSpA is carried out in the same way as r-axSpA. At the same time, it is obvious that nr-axSpA is more heterogeneous than radiographic, which can determine the peculiarities of patient management tactics. The authors cited 2 clinical cases in which they demonstrated the possibility of achieving persistent drug-free remission at an early (less than 6 months from the first occurrence of disease signs) use of secukinumab in patients with nr-axSpA. The clinical, laboratory and radiological data of two patients meeting the criteria of the SpondyloArthritis International Society are presented in detail. The clinical cases described in this paper are of considerable interest to practitioners since they present the first experience of using this drug in patients with nr-axSpA outside the clinical studies. Also, they can become a part of the clinical experience that will form the basis for further nraxSpA study with the subsequent development of individual clinical recommendations for the treatment of this disease. KEYWORDS: axial spondyloarthritis, non-radiographic axial spondyloarthritis, secukinumab, early treatment, remission. FOR CITATION: Gaydukova I.Z., Mazurov V.I., Inamova O.V. Secukinumab for non-radiographic axial spondyloarthritis. Russian Medical Inquiry. 2021;5(5):294–300 (in Russ.). DOI: 10.32364/2587-6821-2021-5-5-294-300.
Stress and nutrition
Authors:   International Society of Stress ", Akarachkova E.S. ,   Stress Under Control",   , Moscow, Russian Federation, Belyaev A.A. ,   N.V. Sklifosovsky Research Institute for Emergency Medical Aid, Moscow, Russian Federation, Kadyrova L.R. ,   Kazan State Medical Academy, the branch of the Russian Medical Academy of Continuous Professional Education, Kazan, Russian Federation, Klimov L.V. ,   Federal Center for the Brain and Neurotechnologies of the Federal Medical Biological Agency, Moscow, Russian Federation,   Integritas Clinic LLC, Moscow, Russian Federation, Kotova O.V. ,   International Society of Stress "Stress Under Control", Moscow, Russian Federation,   Russian University of Peoples’ Friendship, Moscow, Russian Federation
Published: October 2021

In recent years, there has been a tendency to identify stress with nervous tension, but stress is not only a reaction to unpleasant experiences or conflicts but also a general adaptation syndrome. All factors (of the external and internal environment) that affect homeostasis cause a stress reaction that is implemented in several stages. And anxiety, the purpose of which is to mobilize resources, is an important stage of this process. It is necessary to maintain homeostasis and adapt the body to new conditions. The ability of the body to properly allocate reserves and adapt to stress is called stress resistance. In case of prolonged stress, anxiety becomes pathological leading to adaptive reserve depletion, and, consequently, stress resistance decreases and vulnerability to any stressful factors increases. Could nutrition reduce anxiety and increase stress resistance? What adaptation mechanisms are damaged by regular improper nutrition? In this article, we tried to answer these questions. Regular consumption of certain foods creates favorable conditions for adaptation, reducing the burden of the stress consequences. A healthy lifestyle, including proper nutrition, exercise, rest and the development of positive coping skills, can significantly change the ability to adapt, increase stress resistance and minimize the stress effects. KEYWORDS: food, stress, anxiety, stress resistance, homeostasis, adaptation syndrome. FOR CITATION: Akarachkova E.S., Belyaev A.A., Kadyrova L.R. et al. Stress and nutrition. Russian Medical Inquiry. 2021;5(5):316–321 (in Russ.). DOI: 10.32364/2587-6821-2021-5-5-316-321.
On the issue of complex diagnostic radiology of inflammatory bone diseases in children at an early stage
Authors:   A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russian Federation, Sholokhova N.A. ,   St. Vladimir Children’s City Clinical Hospital, Moscow, Russian Federation, Olkhova E.B. ,   A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russian Federation,   St. Vladimir Children’s City Clinical Hospital, Moscow, Russian Federation
Published: October 2021

Aim: to study the possibilities of diagnostic radiology methods for changes in metaphyses and epiphyses at an early stage of the inflammatory process in children aged 1 and older and adolescents. Patients and Methods: 76 emergency patients with a diagnosis of acute metaepiphysial hematogenous osteomyelitis were examined using standard radiography (SR), ultrasonography (US), magnetic resonance imaging (MRI) and computed tomography (CT). The age of the patients ranged from 1 to 18 years. All patients in the admission department underwent US and SR with a mandatory examination of the contralateral region. After analyzing the obtained data, additional examination algorithms were formed using MRI and CT. Results and Discussion: US of the targeted area was descriptive concerning the soft tissue pathological component: paraosseous soft tissues edema was determined in 75%, structural changes of the joint, in particular, synovitis — in 78.9%, joint effusion — in 57.9%. X-ray examination had a limited opportunity to detect destructive changes in bone tissue at the early stages of the pathological process (6.6%). At the same time, MRI revealed the maximum number of semiotic signs of acute hematogenous osteomyelitis, the most significant of which were: trabecular bone marrow edema (100%), periosteal changes (96.1%) and extraosseous changes (98.5%). CT was performed in 26 patients with multifocal disease, as well as in the late stage of the inflammatory process for preoperative planning. Bone destruction at an early stage occurred in 32.7% of patients, a change in the growth area — in 81.0 % of cases. Along with these semiotic signs, sequesters (55.3 %) and fistula tracts (31.3%) were visualized. Conclusion: the obtained results made it possible to systematize information on the diagnostic radiology efficacy for acute metaphyseal and epiphyseal lesions in the early stage of the inflammatory process in children aged 1 and older and adolescents. KEYWORDS: osteomyelitis, epiphysis, metaphysis, diagnostic radiology, pediatrics. FOR CITATION: Sholokhova N.A., Olkhova E.B. On the issue of complex diagnostic radiology of inflammatory bone diseases in children at an early stage. Russian Medical Inquiry. 2021;5(5):330–334 (in Russ.). DOI: 10.32364/2587-6821-2021-5-5-330-334.
Cardiac risk stratification in patients with non-alcoholic fatty liver disease and cholelithiasis
Authors:   Omsk State Medical University, Omsk, Russian Federation, Krolevets T.S. , Livzan M.A. ,   Omsk State Medical University, Omsk, Russian Federation, Cherkashchenko N.A. ,   West Siberian Medical Center of the Federal Medical and Biological Agency, Omsk, Russian Federation, Gorbenko A.V. ,   Omsk State Medical University, Omsk, Russian Federation, Nikolaev N.A. ,   Omsk State Medical University, Omsk, Russian Federation
Published: October 2021

Aim: to increase the efficacy of patient management, to assess the risk of developing cardiovascular diseases (CVD) with the fatal outcome for 10 years in patients with comorbid cholelithiasis (C) and non-alcoholic fatty liver disease (NAFLD). Patients and Methods: 183 patients with NAFLD participated in an open comparative study. The main group (n=88) consisted of subjects with comorbid NAFLD and C, of which 53 patients have a history of cholecystectomy (CE). The comparison group consisted of patients with NAFLD only (n=95). The risk of CVD with fatal outcome in the comorbid course of NAFLD and C was assessed according to the SCORE 2019 scale for regions with an increased risk. A scale of relative total CVD risk was used for people under 40 years of age. Results: the detection rate of CHD, is positively correlated with comorbid course of NAFLD and C (25% — in the main group, and 9.47% — in the comparison group, χ2=7.83, p<0,01, rs=0,207, R<0.01), and the correlation increases among people with CE (rs=0,258, R<0,01). In the comparison group, prediabetes was significantly more commonly detected (χ2=8.24, p<0.01, r s=-0.212, p<0,01). Patients after CE had a higher level of LDL cholesterol (rs=0.228, p≤0.01). Patients with NAFLD are characterized by hyperleptinemia and leptin resistance along with insulin resistance. Patients after CE have the highest level of leptin (p<0.001). Subjects with a comorbid course of NAFLD, C and CE in the history have a significantly higher risk of CVD with the fatal outcome for 10 years (43.4%) (χ2=9.4140, p<0,01). A correlation of mean level between CE and high CVD risk was revealed (r=-0,4341, p≤0.01). Conclusion: the factors causing the comorbid course of NAFLD and C are also concerning the CVD progression. Stratification of patients by CVD risk groups and metabolic status can become an indispensable tool in the clinicians’ arsenal. KEYWORDS: cardiovascular risk, non-alcoholic fatty liver disease, cholelithiasis, cholecystectomy. FOR CITATION: Krolevets T.S., Livzan M.A., Cherkashchenko N.A. et al. Cardiac risk stratification in patients with non-alcoholic fatty liver disease and cholelithiasis. Russian Medical Inquiry. 2021;5(6):377–384 (in Russ.). DOI: 10.32364/2587-6821-2021-5-6-377-384.
New methods to the patient management with irritable bowel syndrome
Authors:   Omsk State Medical University, Omsk, Russian Federation, Livzan M.A. , Gaus O.V. ,   Omsk State Medical University, Omsk, Russian Federation
Published: October 2021

Aim: to evaluate the efficacy and safety of Kolofort® in the treatment of patients with moderate to mild irritable bowel syndrome (IBS). Patients and Methods: an open cohort prospective placebo-controlled study was conducted with the inclusion of 30 patients (average age 30.7±7.8 years) with an established diagnosis of IBS. The control group consisted of 10 healthy subjects. Kolofort® was prescribed for a course of 12 weeks, 2 tablets 2 times a day. All patients were evaluated before and after the therapy course for the main clinical symptoms of IBS, as well as the severity of anxiety and depression, the level of specific anxiety regarding GIT symptoms and life quality. Cortisol levels in the morning and evening portions of saliva were determined in healthy subjects and patients with IBS. Results: initially, patients with IBS had a high level of anxiety and depression, a high index of visceral hyperssensitivity, and a low life quality. In patients with IBS, the cortisol level in the morning and evening portions of saliva before treatment was statistically significantly higher than in healthy subjects (in both cases, p<0,05). After 12 weeks of therapy, there was a statistically significant decrease in the severity of clinical manifestations of the disease (p<0,05), in the severity of depression, anxiety, visceral hypersensitivity and an increase in the life quality. After the therapy course, patients with IBS noted a significant decrease in the cortisol level in the morning and evening portions of saliva. During therapy, 3 adverse events were registered: headache (n=2), nausea (n=1), which did not require drug discontinuation. Conclusion: the efficacy of Kolofort® in the treatment of patients with IBS with a moderate and mild disease course, both in relation to the main GIT symptoms and concomitant psychoemotional disorders, has been shown. Good efficacy and tolerability of the drug ensured high patient adherence to the treatment. KEYWORDS: irritable bowel syndrome, cortisol, stress, Kolofort, visceral hyperssensitivity, anxiety. FOR CITATION: Livzan M.A., Gaus O.V. New methods to the patient management with irritable bowel syndrome. Russian Medical Inquiry. 2021;5(6):391–397 (in Russ.). DOI: 10.32364/2587-6821-2021-5-6-391-397.
Are proton pump inhibitors close or distant relatives? (Lecture)
Authors:   Non-State Educational Private Institution Of Additional Professional Education ", Plyusnin S.V. ,   Medical Dental Institute",   , Moscow, Russian Federation
Published: October 2021

Proton pump inhibitors (PPIs) are drugs that block H+-K+-ATPase on the apical membrane of the gastric parietal cells. Due to this pharmacological effect, it is possible to achieve inhibition of hydrochloric acid and its secretion formation. To date, 6 PPIs (under an international nonproprietary name) have been registered in the Russian Federation. PPIs, having proven efficacy and safety in many clinical studies, have several patterns reflected in their patient information leaflet. The attending physician should pay attention to these patterns before starting PPIs therapy. The author considers the characteristics of pharmacokinetics, pharmacodynamics of various PPIs, as well as the issues concerning efficacy and safety of use. The lecture also discusses the adverse events of PPIs, including rare ones, such as mental disorders (hallucinations), bronchospasm, subacute cutaneous lupus erythematosus. The author focuses on the metabolism peculiarities of various PPIs and the possibility of adverse drug interactions. It is especially important to consider the PPIs administration in the treatment of elderly and senile patients, patients with liver failure, during the eradication of Helicobacter pylori. KEYWORDS: proton pump inhibitors, patient information leaflet, adverse events, eradication, Helicobacter pylori. FOR CITATION: Plyusnin S.V. Are proton pump inhibitors close or distant relatives? (Lecture). Russian Medical Inquiry. 2021;5(6):398– 403 (in Russ.). DOI: 10.32364/2587-6821-2021-5-6-398-403.