bluuebunny/crossref_metadata_2025 huggingface dataset:
MIGRAINE
Authors: Ilie Milena Monica , Ciurea Alexandru Vlad , Toader Corneliu , Costin Horia Petre , Covlea Christian Adelin
Published: November 2024

Background
Migraine is a prevalent neurological disorder characterized by chronic headaches, significantly impacting the global population. This comprehensive review aims to advance the understanding of migraine pathogenesis and treatment, focusing on molecular markers and novel therapeutic strategies.
Material
Molecular markers such as calcitonin gene-related peptide (CGRP) and their role in migraine development. Traditional medical treatments and emerging therapeutic strategies, including neuromodulation, are analyzed for their effectiveness and limitations. Clinical studies and imaging techniques are leveraged to identify key mechanisms and triggers in migraine pathology.
Approximately 95% of people experience a headache at some point, with migraines being a significant contributor. Migraine is recognized by the World Health Organization as one of the top ten causes of disability globally, particularly affecting women. CGRP is identified as a crucial factor in migraine development. Inhibitors targeting CGRP have shown significant effectiveness in managing migraines. Other molecular markers, including proinflammatory cytokines and neurotransmitters, are discussed for their roles in pain transmission and migraine pathophysiology. Traditional treatments, such as triptans and NSAIDs, are evaluated alongside new therapies, including CGRP inhibitors and neuromodulation techniques. Neuromodulation, involving devices like external trigeminal nerve stimulators, shows promise in migraine management. Genetic markers associated with familial hemiplegic migraine (FHM) and common migraine forms are reviewed. Recent genome-wide association studies (GWAS) have identified several genetic variants linked to migraine susceptibility.
Conclusion
This presentation enhances the understanding of migraine pathogenesis and introduces novel therapeutic possibilities. By focusing on molecular markers like CGRP and exploring advanced treatment options, the study aims to improve migraine management and patient care. The findings underscore the need for continued research and innovation in migraine treatments to reduce the global burden of this debilitating condition.
BRIDGING TECHNOLOGY AND NEUROSURGERY
Authors: Saceleanu Vicentiu , Cindea Cosmin , Breazu Alexandru , Lucaciu Sonia
Published: November 2024

Objectives
The BrainIT project aimed to revolutionize neurosurgical practices by integrating advanced technologies to enhance the precision and outcomes of neuro-oncology and neurovascular surgeries. The project sought to address the growing need for technological innovation in neurosurgery to improve patient outcomes and surgical efficiency.
 
Study Stages
The project encompassed several key stages. Initially, comprehensive e-learning modules were developed to provide continuous education and training for neurosurgeons, ensuring they stayed updated with the latest technological advancements. Concurrently, extensive research was conducted to explore the applications and benefits of cutting-edge technologies in neurosurgery. This research was pivotal in identifying new methods and tools that could be integrated into surgical practices.
 
To facilitate knowledge exchange and collaboration, the project organized international conferences and workshops. These events brought together neurosurgical professionals from around the world, fostering a collaborative environment where ideas and innovations could be shared. Additionally, strategic partnerships were established with leading institutions and organizations. These partnerships were crucial in promoting interdisciplinary collaborations, which were essential for the successful implementation and impact of the project.
 
Supported by the European Commission, the BrainIT project emphasized the importance of disseminating innovative practices and findings within the medical community. This dissemination ensured that the knowledge and advancements generated by the project were widely adopted and implemented, ultimately benefiting the broader medical field.
 
Conclusions
The integration of advanced technologies within the BrainIT project has demonstrated significant improvements in surgical precision and patient outcomes. These findings highlight the crucial role of interdisciplinary collaboration and continuous innovation in the advancement of neurosurgical practices. The project serves as a model for integrating technology and medicine, underscoring its potential to shape future neurosurgical methodologies. The successful implementation of the BrainIT project showcases the potential for technological advancements to revolutionize medical practices and improve patient care on a global scale.
MACHINE LEARNING-BASED PREDICTION OF CLINICAL OUTCOMES IN MICROSURGICAL CLIPPING TREATMENTS OF CEREBRAL ANEURYSMS
Authors: Serban Matei , Toader Corneliu , Buica Vlad , Dumitrascu David , Ciurea Alexandru Vlad
Published: November 2024

Background
This study investigates the application of Machine Learning (ML) techniques to predict clinical outcomes in microsurgical clipping treatments of cerebral aneurysms. The goal is to enhance healthcare processes through informed clinical decision-making by utilizing a dataset of 344 patients' preoperative characteristics.Methods
Various ML classifiers were trained to predict outcomes measured by the Glasgow Outcome Scale (GOS). The dataset included 344 patients who underwent microsurgical clipping for intracranial aneurysms. Key features in the dataset included age, aneurysm diameter and neck, arterial hypertension, atherosclerosis, obesity, intubation, vasospasm, and hemorrhage. The study evaluated the models using ROC-AUC scores for outcome prediction and identified key predictors using SHAP analysis.
 
Results
-    Model Performance: The models achieved ROC-AUC scores of 0.72 ± 0.03 for specific GOS outcome prediction and 0.78 ± 0.02 for binary classification of outcomes.
-    Key Predictors: SHAP analysis identified intubation as the most impactful factor influencing treatment outcome predictions. Other significant predictors included vasospasm and the Hunt and Hess Scale.
-    Patient Demographics: The study included 344 patients with a mean age of 55.05 ± 11.45 years. Gender discrepancy was noted, with 219 females (63.7%).
-    Aneurysm Characteristics: The mean aneurysm neck was 3.93 ± 1.64 mm. Most aneurysms were of the saccular or berry type, with 308 cases (89.5%) being ruptured and 311 cases (90.4%) presenting with hemorrhage.
Conclusions
The study demonstrates the potential of ML in predicting surgical outcomes of cerebral aneurysm treatments. The findings emphasize the need for high-quality datasets and external validation to enhance model accuracy and generalizability. The integration of ML into clinical practice can potentially improve patient management and treatment outcomes in neurosurgery. The study contributes to the ongoing efforts in the medical AI community, supporting the use of ML techniques to enhance clinical decision-making and patient care.
GAMMA-KNIFE RADIOSURGERY IN ACOUSTIC NEUROMA
Authors: Stoica Fery , Perin Radu , Neamtu Daniela
Published: November 2024

Lesions of the cerebellopontine angle (CPA) are frequent and represent 6%–10% of all intracranial tumors. Acoustic neuromas, which are also called vestibular schwannomas, along with meningiomas are the two most frequent lesions and account for approximately 85%–90% of all CPA tumors.
 
These benign lesions involving the middle ear comprise a diverse spectrum of local manifestations within the temporal bone. Despite their usually benign histopathological characteristics, these lesions may be locally destructive. Prompt diagnosis and treatment are therefore necessary to prevent progression of audiologic, vestibular, and facial nerve dysfunction, which may also be present.
 
Because of the surgically formidable anatomical location of these tumors, curative resection often proves challenging. Treatment options include surgical resection, stereotactic radiosurgery (SRS), hypofractionated stereotactic radiotherapy (SRT), alone or in combination.
 
Stereotactic radiosurgery is a minimally invasive option for management of skull base tumors. Brain stereotactic radiosurgery involves the use of precisely directed closed skull single fraction (one surgical session) radiation to create a desired radiobiologic response within the target with minimal effects to surrounding structures or tissues.
Stereotactic radiosurgery is associated with a high rate of local tumor control and a low risk of neurologic complications for patients with skull base tumors. Stereotactic radiosurgery can be used as an up-front treatment or as an adjuvant therapy for patients with recurrent or residual tumor after surgical resection.
 
The superior safety efficacy of stereotactic radiosurgery over microsurgery in small- to middle-sized vestibular schwannomas is demonstrated in worldwide comparative studies. Normal motor facial nerve function and serviceable hearing are more likely to be preserved with radiosurgery as compared with microsurgery. In very large schwannomas, a combined approach with a deliberate subtotal removal with functional monitoring of the facial nerve followed by radiosurgery of the remnant dramatically reduces the risk of facial palsy as compared with radical removal.
 
Hypofractionation of radiosurgery (stereotactic radiotherapy or multisession radiosurgery) has failed until now to demonstrate any advantage over single-dose, high-precision radiosurgery.
 
Literature has documented the cost savings benefit of stereotactic radiosurgery versus invasive surgical procedures and the lower risk potential of bleeding, anaesthesia problems, infections, and side effects which may result in transient or permanent disabilities from open surgery.
 
At the same time, literature has demonstrated that the risk of radiation-associated intracranial malignancy after stereotactic radiosurgery was found to be similar to the risk of developing a malignant CNS tumour in the general population of the USA and some European countries as estimated by the CBTRUS and IARC data, respectively.
DUAL MANIFESTATION OF INTRACRANIAL AND SPINAL CORD CAVERNOMAS
Authors: Zaharia M.C. , Andrasi C.M. , Popescu G. , Neacsu A. , Gorgan Radu Mircea
Published: November 2024

Introduction
Cerebral and spinal cord cavernomas are vascular anomalies of the nervous system characterized by dilated vessels lined with a single layer of endothelium. They exhibit minimal blood flow and can occur in both the brain and spinal cord. They affect approximately 0.5% of the population and constitute 15% of cerebral vascular malformations. While spinal cavernomas are less common, they can cause significant morbidity due to the risk of hemorrhage and resulting neurological deficits. Surgical removal to completely eliminate the vascular abnormality is the preferred treatment.
 
Material and Methods
We present the case of a 66-year-old female patient who presented to our clinic with headache, dizziness, and left-sided hemiparesis, predominantly affecting the lower limb. Cerebral MRI revealed an intracranial mass in the left parietal lobe with signs of acute bleeding. Due to clinical symptom discrepancies and imaging findings, cervical MRI was performed, revealing an intramedullary tumor formation adjacent to the C4-C5 vertebral bodies. The patient underwent two surgeries, achieving total ablation of the lesions.
 
Results
Post-operative CT confirmed complete ablation of the cavernomas. No neurological deficits were reported after removal of the parietal cavernoma. One month after the first surgical intervention, the patient underwent a second surgery to excise the cervical tumor. Postoperatively, the patient experienced numbness in the left hand, which improved in the first week postoperatively.
 
Conclusions
The prevalence of associated intracranial cavernous malformations (CMs) in patients with spinal cord CMs was found to be 5 to 12% and typically observed in patients with the familial form of the condition. The coexistence of intracranial and spinal cord CMs is more likely to lead to aggressive disease progression. Therefore, it is imperative that both lesions are surgically removed within 30 days of each other. Managing cavernomas remains a complex clinical decision, often balancing intervention risks against potential neurological morbidity.
La valoración probatoria en violencia política de género: importancia de la especialización de los peritos
Authors: Valverde Cuenca Diana Carolina , Ron Zambrano Marlon Andrés , García Segarra Holger Geovannny
Published: November 2024

Este artículo investigó la valoración de la prueba en casos de violencia política de género, destacando la importancia de la especialización de los peritos. La introducción abordó la creciente relevancia de este tipo de violencia. El objetivo fue resaltar como la especialización pericial mejora la calidad y precisión de las pruebas en estos casos. El método consistió en un análisis de casos judiciales y entrevistas con expertos en violencia de género. Los resultados mostraron que los peritos especializados proporcionan informes más detallados y útiles, ayudando a entender la gravedad de la violencia y sus efectos. Las conclusiones indicaron que una pericia especializada es crucial para garantizar que las decisiones judiciales electorales sean justas y efectivas, así como para ofrecer una mejor protección y apoyo a las víctimas.
Análisis comparativo entre la justicia ordinaria y la constitucional respecto a la tutela judicial efectiva en los derechos sindicales
Authors: Guzman Samaniego Nixon Wesner , Gonzabay Flores Jorge Luis , Freire Gaibor Edward Fabricio
Published: November 2024

La justicia ordinaria se refiere al sistema jurídico estándar, aplicado según la gravedad del caso; la justicia constitucional se enfoca en el cumplimiento y revisión judicial. El presente artículo se enfoca en un análisis comparativo, que tiene por objetivo determinar la interrelación y el contraste que existe entre la justicia ordinaria y la constitucional, al momento de ejercer una tutela judicial efectiva en la protección de derechos sindicales. El método utilizado fue el exegético con enfoque cualitativo, con el diseño documental basado en el análisis de sentencias judiciales. Como resultado, la justicia ordinaria y constitucional en Ecuador, se complementan para garantizar, y ejercer las decisiones en función de los derechos sindicales. Se llega a la conclusión de que la interacción entre justicia ordinaria laboral y constitucional, presentan un avance significativo en los derechos de los trabajadores al momento de ejercer la tutela judicial en la protección de derechos sindicales; por lo cual, ambas buscan garantizar que los derechos laborales sean respetados
Restricción a los derechos humanos aplicación desde el orden jurídico supranacional y la Constitución ecuatoriana
Authors: Galarza Castro Christian Xavier , Colón Ferruzola Enrique , Flores Segura Ángel Gonzalo
Published: November 2024

La limitación a los derechos humanos, desde una perspectiva de la aplicación del orden jurídico supranacional y la Constitución ecuatoriana, presenta una problemática llena de matices. El objetivo es comprender la restricción a los derechos humanos aplicación desde el orden jurídico supranacional y la Constitución ecuatoriana. Se planteó un enfoque cualitativo de carácter descriptivo y diseño documental, que comprende la interpretación de la normativa jurídica, la Constitución ecuatoriana, tratados internacionales de derechos humanos, jurisprudencias de la Corte IDH y de la Corte Constitucional del Ecuador. Los resultados ofrecen una visión de cómo se pueden limitar los derechos humanos en Ecuador, bajo parámetros constitucionales y legales, así como, los instrumentos y acuerdos internacionales a los que se suscribe. Se concluye que, la restricción de derechos debe basarse en principios de legalidad y legitimidad, garantizando que las leyes que impongan tales restricciones sean el resultado de un proceso democrático y respeten el estado de derecho.
Vulneración del derecho a la defensa debido a la citación incorrecta en los procesos de alimentos
Authors: Bravo Abad Willian Ariel , Chuni Patino Edinson Alberto , Freire Gaibor Edward Fabricio , Gonzabay Flores Jorge Luis
Published: November 2024

El derecho a la defensa, un pilar fundamental en cualquier sistema jurídico, se ve constantemente desafiado en la práctica. El objetivo del estudio es analizar la vulneración del derecho a la defensa debido a la citación incorrecta en los procesos de alimentos en Ecuador. Es enfoque mixto, combinando el análisis documental jurídico con un componente cuantitativo basado en el análisis de encuestas a abogados. Se asume el análisis de criterios doctrinarios y normativos. Los resultados revelan que, los retrasos en la citación del demandado en los juicios de alimentos, además de constituir un vicio en sí mismo, provoca un grave daño al patrimonio del demandado. Se concluye las demoras en la citación incorrecta de una demanda de alimentos generan un impacto negativo significativo en el alimentante. Además, al enterarse tardíamente de su obligación alimentaria, que podría haberse originado hace tiempo, el deudor se ve sometido a una carga económica considerable de forma abrupta.
Construcción de cárceles de máxima seguridad en las zonas de la Amazonía y Costa Pacifico de Ecuador
Authors: Reyes Mantuano Diego
Published: November 2024

El artículo aborda la problemática de las cárceles de máxima seguridad en Ecuador, enfocándose en los riesgos que su ubicación en áreas urbanas representa para la seguridad y bienestar de la población. El objetivo del estudio es examinar la construcción de cárceles de máxima seguridad en las zonas de la Amazonía y Costa Pacifico de Ecuador. Con enfoque cualitativo, tipo descriptiva y exploratoria, con paradigma interpretativo, método hermenéutico y diseño documental. Se llevó a cabo una revisión documental basada en informes de organismos internacionales, estudios de caso y opiniones de expertos. Los resultados sugieren que, la reubicación de cárceles en áreas remotas podría dificultar este acceso, afectando negativamente a los reclusos y sus familias, e incluso puede tener un impacto ambiental considerable. Como conclusión, se debe incluir la gestión privada en estas nuevas instalaciones, implementando estándares internacionales de seguridad y rehabilitación a fin de no comprometer el bienestar de los reclusos y sus familias
Studies on the behavior of the bis-complex of Pt(IV) with the tridentate ligand all-cis-2,4,6-triaminocyclohexane-1,3,5-triol in aqueous solutions
Authors:   Faculty of Chemistry and Pharmacy, Sofia University “St. Kliment Ohridski”, 1, J. Bourchier Blvd., 1164 Sofia, Bulgaria, Velcheva V.N. , Morgenstern B. ,   Fachrichtung Chemie, Universität des Saarlandes, Campus, D-66123 Saarbrücken, Germany, Hegetschweiler K. ,   Fachrichtung Chemie, Universität des Saarlandes, Campus, D-66123 Saarbrücken, Germany, Gencheva G. G. ,   Faculty of Chemistry and Pharmacy, Sofia University “St. Kliment Ohridski”, 1, J. Bourchier Blvd., 1164 Sofia, Bulgaria
Published: November 2024

NMR spectroscopy and high-resolution mass spectrometry were applied to study the stability of the complex cation [Pt(taci)2]4+ known as ditaciplatin in aqueous solutions at varying acidity and in the presence of monodentate ligands. Ditaciplatin is a cationic part of the bis-complex of Pt(IV) with the tridentate ligand all-cis-2,4,6-triaminocyclohexane-1,3,5-triol (taci) with a composition [Pt(taci)2](CO3)2·6H2O (2A). It was found that the ditaciplatin complex is stable in solution at all of the studied conditions within the period of 7 days. Three new compounds were isolated in the experiments in solution, namely: [Pt(taci)2](CO3)1.5(OH)·7H2O (2B), [Pt(taci)2](Cl)4·H2O (2C) and [Pt(taci)2](NO3)4·2H2O (2D). 2B and 2C crystalize in triclinic crystal system P-1 and 2D – in monoclinic Р21/n. The cationic part of the compounds is ditaciplatin and the counterions depend on the synthetic conditions.
Crystals of binary rare-earth metal germanides grown in molten indium. Synthesis and structural characterization of Nd3Ge5 and Lu3Ge4
Authors:   Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, USA, Zhang J. ,   School of Materials Science and Engineering, Dalian Jiaotong University, Dalian 116028, P.R. China, Bobev S.
Published: November 2024

Reported are the synthesis and the crystal structure determination of a new polymorphic form of the rare-earth metal germanide Nd3Ge5. As established by single-crystal X-ray diffraction methods, Nd3Ge5 crystallizes in a hexagonal crystal system with the space group P 2c (No. 190, Z = 2). The unit cell parameters are a = 6.9964(3) Å and c = 8.5820(8) Å. The structure is a derivative of the common structure type AlB2 (space group P6/mmm) where the atoms are stacked in a hexagonal close-packed manner. Digermanide NdGe2 is not known, rather the phase exists as NdGe2–x (x < 0) with a sizeable number of germanium vacancies. When the defect concentration reaches x = 1/3, the vacant Ge sites can undergo long-range ordering, resulting in the formation of Nd3Ge5 (=NdGe1.67). Therefore, the atomic arrangement can be described as a 6-fold superstructure of the AlB2 type structure (a' = a × 31/2 and c' = c × 2) with flat Ge layers, where every 6th Ge atom is missing; the Ge layers are stacked along the crystallographic c-axis, and are separated by hexagonal layers of rare-earth metal atoms. This is a new polymorph of Nd3Ge5, with the other form being orthorhombic and structurally related to another commonly observed structure, that of ThSi2. Besides the structure of Nd3Ge5, we also report the structure of the known phase Lu3Ge4, which has been previously identified from its powder diffraction pattern but never refined. Lu3Ge4 is isotypic with the rest of the REGe4 germanides (RE = Gd–Tm) and crystallizes in an orthorhombic crystal system with the space group Cmcm (No. 63, Z = 4) with unit-cell parameters a = 3.9591(8) Å; b = 10.429(2) Å; c = 14.019(3) Å.
Mojsije u Starom zavjetu i istoimenoj pjesmi Silvija Strahimira Kranjčevića
Authors: Dragić Helena
Published: November 2024

Mojsije Božji je sluga Jahvin, sugovornik i posrednik koji narodu prenosi Božje riječi i odredbe. Na Božjem brdu Horebu anđeo mu se ukazao u gorućem grmu koji nije izgarao. Iz toga grma Jahve se javio Mojsiju. Mojsije je po Jahvinoj providnosti izraelski narod preko Crvenoga mora izveo iz egipatskoga ropstva u Sinajsku pustinju. Na Sinaju mu je Jahve dao Deset zapovijedi i druge propise. Dok je Mojsije četrdeset dana i noći pred Jahvom boravio na Sinaju, Izraelci su se okrenuli od Jahve i klanjali zlatnom teletu. Mojsije je molio Svemogućega da ne kažnjava narod. Gospodin je narodu oprostio, ali ih je kaznio da četrdeset godina borave u pustinji. Mojsije je otišao na brdo Nebo na vrhunac Pisge nasuprot Jerihonu, gdje mu je Jahve pokazao obećanu zemlju. Mojsije je tada umro u 120. godini života. Mojsije je trajno nadahnuće pjesnicima, slikarima, kiparima, redateljima i drugim umjetnicima. Najveći hrvatski pjesnik realizma Silvije Strahimir Kranjčević 1893. god. u Viencu je objavio pjesmu Mojsije. Kranjčevićeva pjesma u suglasju je sa starozavjetnim knjigama.
Nutrição e afeto: aleitamento e introdução alimentar – um relato de experiência
Authors: Silva Flávia Eloah Martins da , Neiverth Tais , Burdini Natalia Cristina , Vieira Mateus Umpiérrez , Mazuco Gianna Freire , Berezovski Maria Clara Souza , Kurzydlovski Izabel Caroline de Lima , Schemberger Julia Gouveia , Mittelstedt Maria Luiza Dinies , Mendes Jeisy Tonatto , Cristo Ticiane Nicoli de , Siqueira Eduarda Rogalski de , Zagonel Maria Luiza Dalzotto , Patel Raissa , Silveira Jonathan Cechin da
Published: November 2024

Desde o aleitamento materno exclusivo até a alimentação sólida, a nutrição na infância se faz essencial para o desenvolvimento adequado da criança. Nesse sentido, foi desenvolvido um projeto de extensão a fim de disseminar informações baseadas na literatura científica atual sobre aspectos nutricionais que influenciam na qualidade de vida infantil. Esse estudo tem como objetivo descrever os resultados obtidos após a aplicação do projeto “Nutrição e afeto: aleitamento e introdução alimentar”. Este foi desenvolvido por acadêmicos do curso de medicina, com auxílio de uma médica pediatra. Materiais como slides e panfletos foram elaborados sobre amamentação, primeiros socorros, introdução alimentar e desmame, sendo expostos em um centro de educação infantil para familiares de crianças entre 6 meses e 1 ano e meio de vida, conforme a demanda, e esclarecendo suas dúvidas. O planejamento das atividades desenvolvidas foi imprescindível para uma boa realização dessas, pois mostraram impactos significativos na comunidade através da conscientização sobre a temática e da aplicação prática das técnicas apresentadas. Além disso, o centro educacional aproveitou a ação de extensão para realizar um ambiente específico de amamentação. Portanto, concluiu-se a importância de ações de educação em saúde sobre a nutrição infantil a fim de contribuir com um desenvolvimento saudável das crianças associado à construção de uma comunidade bem informada.
Hemiepifisiodese lateral do primeiro metatarso no tratamento do hálux valgo juvenil: uma revisão de literatura
Authors: Falcão Rhayana Oliveira , Paixão Gustavo Henrique Cavalcanti Pereira , Sá Gabrielly Gomes Lima de , Falcão Rayan Oliveira , Vieira Mariana Moraes , Cruz Mário Augusto Ferreira
Published: November 2024

Considerando a prevalência do Hálux Valgo Juvenil (HVJ) e as limitações da maturidade óssea, este trabalho justifica-se pela necessidade de tratamentos eficazes e menos invasivos. O problema reside na elevada taxa de recorrência e complicações das osteotomias tradicionais. Objetiva-se, portanto, analisar as repercussões da hemiepifisiodese lateral do primeiro metatarso como alternativa para o tratamento do HVJ. Para tanto, procede-se a uma revisão integrativa da literatura, utilizando as bases de dados PubMed e SciELO, com critérios de inclusão artigos publicados nos últimos 10 anos, nos idiomas espanhol, inglês ou português, com temáticas pertinentes e que estivessem disponíveis na íntegra. Observa-se que, nos três estudos selecionados, totalizando 82 pés analisados, a hemiepifisiodese resultou em correção dos ângulos do hálux valgo e intermetatarsal, com redução da dor e melhora funcional. Assim, conclui-se que a hemiepifisiodese é uma técnica promissora para correção gradual do HVJ, com baixa taxa de complicações, sendo especialmente indicada para pacientes jovens com potencial de crescimento ósseo.
Metabolismo do cálcio em crianças com microcefalia: um estudo em uma coorte
Authors: Maciel Renata Franco , Rodrigues Letycia Santos , Bittencourt Anna Lillian Canuto , Miranda Phelipe Brito de , Silva Carla Thayná de Santana , Leite Rebecca Schuster Dorea , Guerra Julia Franco Maciel , Bispo Ana Jovina Barreto
Published: November 2024

A microcefalia, definida pela Organização Mundial da Saúde como perímetro cefálico inferior a -2 desvios padrão da mediana, está associada a um risco elevado de disfunções motoras e endócrinas, levando a disfagias, desnutrição energético-proteica e deficiências de macro e micronutrientes. O presente estudo objetivou avaliar a evolução antropométrica e o metabolismo do cálcio em crianças com microcefalia acompanhadas em um ambulatório de referência no Estado de Sergipe. Para tanto, foi realizado um estudo observacional e descritivo em uma coorte de pacientes com diagnóstico de microcefalia, analisando-se parâmetros antropométricos (peso, estatura, IMC) e níveis séricos de cálcio, fósforo, fosfatase alcalina e vitamina D, do segundo ao sexto ano de vida. Observou-se que as frequências de crianças com crescimento inadequado variaram entre 12,8% e 32% para peso, zero a 12% para estatura e 19% a 40,9% para IMC, enquanto os parâmetros séricos de cálcio, fosfatase alcalina e vitamina D apresentaram alterações entre 17,6% e 50% ao longo dos anos. Apesar do risco, não foi verificado comprometimento importante dos valores de cálcio, fosfatase alcalina e vitamina D, assim como do peso.  Acreditamos que acompanhamento regular da amostra permitiu identificar e corrigir essas alterações, reforçando a importância de um seguimento multidisciplinar sistemático para prevenir déficits prolongados e suas consequências no crescimento das crianças com microcefalia.
Desafios para os sistemas adesivos autocondicionantes: revisão de literatura
Authors: Silva Sílvia de Fátima Porto da , Gomes Louise Costa Machado , Mendonça Izabel Cristina Gomes de
Published: November 2024

Com o surgimento das resinas compostas a prática da odontologia restauradora teve uma relevante expansão, principalmente pela promoção significativa da estética. Para tanto é necessário a aplicação de um agente de união entre os substratos dentários e os sintéticos, o que ocorre por meio de sistemas adesivos. Atualmente os sistemas adesivos autocondicionantes se tornaram uma alternativa inovadora por simplificarem a técnica, reduzirem o tempo de procedimento e a margem de erro. Contudo o seu uso apontou uma série de desafios técnicos e clínicos que merecem ser considerados. Neste sentido, o presente trabalho visa reunir e sintetizar as principais informações sobre o tema abordando os resultados sobre os desafios técnicos e clínicos associados ao uso dos sistemas adesivos autocondicionantes a partir de uma revisão da literatura com base em estudos publicados a partir de 2018 e disponibilizados nas plataformas de busca do SciELO e Google Acadêmico. Os resultados encontrados apontam a garantia da adesão como um dos principais desafios, considerando as diferentes respostas das estruturas dentais aos sistemas adesivos autocondicionantes, bem como a necessidade de habilidade técnica por parte do cirurgião-dentista por meio de treinamentos e educação contínua como fatores essenciais para assegurar a eficácia destes sistemas.
Exodontia de múltiplos supranumerários impactados bilateralmente em paciente não sindrômico: relato de caso
Authors: Ferreira Ana Valéria Silva , Ferreira Ana Paula Aguiar , Rosa Marina Rolo Pinheiro da
Published: November 2024

Os dentes supranumerários são anomalias dentárias caracterizadas pelo aumento no número de dentes além do habitual. Esses dentes frequentemente apresentam formato cônico e seu manejo depende de fatores como quantidade, localização e patologias associadas. O diagnóstico é geralmente realizado por meio de radiografias panorâmicas e tomografias computadorizadas que auxiliam na identificação de dentes supranumerários impactados e no planejamento cirúrgico. O objetivo deste artigo é relatar o caso de um paciente de 30 anos do sexo masculino com queixa de apinhamentos significativos. Após avaliação clínica e imaginológica, foram identificados dois elementos supranumerários localizados bilateralmente e múltiplos dentes impactados. A abordagem cirúrgica incluiu a remoção dos dentes supranumerários em dois tempos cirúrgicos. Durante o segundo procedimento, um fragmento radicular foi deixado no processo alveolar, por estar muito próximo ao canal mandibular, apresentando condições que indicavam a segurança de sua permanência. Decidiu-se, portanto, proservar e orientar o paciente a realizar tratamento ortodôntico posteriormente. Os achados deste caso reforçam a importância do planejamento adequado no manejo de dentes supranumerários, destacando a relevância de exames de imagem na avaliação e no tratamento das anomalias dentárias.
Síndrome do intestino irritável: fisiopatologia, manejo clínico e impacto psicossocial
Authors: Ponte Isabella Maria Figueiredo Tuma da , Couto Isadora Matias , Vilela José Eduardo Andrade , Caires Luís Augusto Neves de , Fonseca Luiza Viza
Published: November 2024

A Síndrome do Intestino Irritável (SII) é um distúrbio funcional gastrointestinal crônico, caracterizado por sintomas como dor abdominal, distensão, constipação e diarreia. Sua fisiopatologia é complexa e envolve fatores como alterações na motilidade intestinal, hipersensibilidade visceral e disbiose intestinal, com o desequilíbrio da microbiota desempenhando um papel fundamental. A interação entre fatores biológicos, emocionais e ambientais também é crucial, com o estresse, predisposição genética e alterações psicossociais frequentemente exacerbando os sintomas. Além disso, a SII está comumente associada a comorbidades psiquiátricas, como ansiedade, depressão e transtornos do humor, o que agrava a qualidade de vida dos pacientes. O manejo clínico é altamente individualizado e visa o alívio dos sintomas e a melhora da qualidade de vida. Tratamentos farmacológicos, como antiespasmódicos, antidepressivos e medicamentos antidiarreicos, são utilizados de acordo com o perfil do paciente. Entretanto, abordagens dietéticas, como a dieta de baixo FODMAP, têm mostrado eficácia considerável na redução dos sintomas, especialmente os relacionados à disbiose intestinal. Além disso, a identificação de alimentos específicos que desencadeiam os sintomas é uma estratégia importante para o controle da doença. A integração de abordagens psicossociais no tratamento da SII tem se mostrado fundamental. Terapias como a terapia cognitivo-comportamental (TCC), mindfulness e técnicas de relaxamento ajudam a reduzir o impacto psicológico da doença, aliviando sintomas como ansiedade e depressão, comuns entre os pacientes. O apoio psicológico e a educação contínua do paciente são essenciais para diminuir o estigma social associado à SII, promovendo uma melhor adesão ao tratamento e maior controle sobre os sintomas. Futuras perspectivas incluem o desenvolvimento de biomarcadores específicos para diagnóstico e monitoramento da doença, além de terapias personalizadas, como o uso de probióticos e até mesmo transplante fecal. Esses avanços podem oferecer tratamentos mais eficazes, além de melhorar o prognóstico e a qualidade de vida dos pacientes a longo prazo.
الطلب على المنازل في دولة الكويت: تحليل تكاملي
Authors: السلمان مهدي حمزة
Published: November 2024

يمثل الإنفاق الحكومي على القطاع المنزلي أكبر نسبة من برنامج الإعانات الحكومية. وتعمل الدراسة على استخدام منهج التحليل التكاملي لدراسة سلوك الطلب على المنازل في السوق الكويتي. كما تهدف إلى تقدير دالة الطلب على المنازل، لتحديد أهم المتغيرات التي تبين تغيرات الطلب على المديين القصير والطويل، وقد بينت الدراسة وجود علاقة طويلة الأمد بين الطلب على المنازل وبين المتغيرات الرئيسة للطلب عليها في دولة الكويت، وكانت أهم هذه المتغيرات الدخل القومي (GDP)، وحجم نمو السكان وعدد المنازل القائمة. وتظهر كذلك وجود فروق كبيرة في مرونة الطلب بالعلاقة مع المتغيرات المختلفة، وبخاصة فيما يخص الدخل وتغيرات الأسعار.
العلاقة بين الضغوط الوظيفية و الشعور بالإجهاد الوظيفي، و دور الدعم الوظيفي في هذه العلاقة: دراسة مطبقة على العاملين في القطاع الخاص الكويتي
Authors: محمد علي حسين
Published: November 2024

تهدف هذه الدراسة إلى تحديد العلاقة بين كل من الضغوط الوظيفية(متمثلة بغموض الدور، وصراع الدور)، وشعور العاملين بالإجهاد الوظيفي، ودور الدعم الوظيفي في هذه العلاقة. كما تهدف الدراسة إلى تحديد مدى تأثير بعض العوامل الذاتية، مثل العمر، والنوع، ومدة الخدمة، والجنسية، الوظيفة، على إدراكات العاملين لضغوط العمل والدعم الوظيفي الذي يتلقونه، وعلى درجة شعورهم بالإجهاد الوظيفي. وقد تم استخدام عينة مكونة من 324 موظفاً في ثماني منظمات أعمال كويتية، وأظهرت نتائج الدراسة ما يلي: (1) ترتبط الزيادة في درجة الضغوط الوظيفية (غموض الدور، و صراع الدور) بازدياد شعور العاملين بالإجهاد الوظيفي، (2) ترتبط الزيادة في مقدار الدعم الوظيفي الذي يتلقاه العاملون بانخفاض درجة الضغوط الوظيفية ودرجة شعورهم بالإجهاد الوظيفي، (3) يؤدي الدعم الوظيفي دوراً وسيطاً في العلاقة بين غموض الدور و الإجهاد الوظيفي، (4) تتباين إدراكات العاملين للضغوط الوظيفية باختلاف العمر والجنسية ومدة الخدمة، ويتباين العاملون في إدراكهم للدعم الوظيفي باختلاف العمر والنوع ومدة الخدمة، كما يتباين العاملون في درجة شعورهم بالإجهاد الوظيفي باختلاف الجنسية، وطبيعة الوظيفة. وقد نوقشت هذه النتائج، و تم عرض التطبيقات العملية لها.
محددات معدلات الفائدة في دولة الكويت: دراسة تطبيقية
Authors: العمر محمد علي , فرس رياض يوسف , الغالي خليفة بن الحبيب
Published: November 2024

يهدف هذا البحث إلى القيام بدراسة تطبيقية للعوامل المحددة لمعدلات الفائدة، والتي تعد الأداة الأهم من بين أدوات السياسة النقدية للبنك المركزي في دولة الكويت. ويقوم هذا البحث بمحاولة توضيح كيفية استخدام دالة الاستجابة، لتتلاءم مع احتياجات السياسة النقدية في دولة منتجة للنفط كدولة الكويت، حيث إن جزءاً كبيراً من التضخم لا يمكن التحكم فيه. وقد تم في هذا البحث استكشاف سلوك معدلات الفائدة في كل من المدى القصير والمدى الطويل، وذلك باستخدام أسلوب التكامل المشترك، واختبار جرانجر للسببية، وأظهرت النتائج أن كلاًّ من عرض النقود، وسعر الصرف، وأسعار النفط، وأسعار الأصول العقارية، وأسعار الأصول المالية وتعد من المحددات الجوهرية لمعدل الفائدة.
تقويم مشروع قانون ضريبة الدخل الكويتي: دراسة نظرية
Authors: عبدالحكيم الرجبي محمد تيسير , عبدالرحيم علي محمود
Published: November 2024

تهدف الدراسة إلى تقويم مشروع ضريبة الدخل الذي قدمته الحكومة الكويتية إلى مجلس الأمة الكويتي في شهر أغسطس 2004. وتم استخدام أسلوب تحليل المحتوى لمواد المشروع؛ للوقوف على مدى عدالتها، ومرونتها، ومراعاتها لمبدأ التكلفة والمنفعة. وتبين من الدراسة أن ضريبة دخل الأفراد هي ضريبة نوعية، مع أن أنظمة الضريبة الموحدة هي الأكثر شيوعاً في الوقت الحالي بالدول الأخرى. كما أشارت الدراسة إلى ضرورة عدم إعطاء شركات الأشخاص الشخصية المعنوية حتى يتمتع كل شريك متضامن بالإعفاءات الشخصية والعائلية. وأوصت الدراسة بعدم مطالبة الهيئات و المؤسسات العامة والخاصة إبلاغ إدارة الضريبة عن العمليات التي يجرونها مع الممولين للتخفيف عنهم وللحفاظ على أسرار العملاء، وأن يتم تخفيض غرامات تأخير تقديم الإقرار إلى 0,5% بدلاً من 1%. وتسميتها فوائد تأخير بدلاً من غرامات. ووجدنا أن المشروع الضريبي قام بتخفيض معدل الضرائب بهدف تشجيع الاستثمار المحلي والأجنبي، كما أنه منح إعفاءات للأفراد تصل إلى إعفاء معظم أصحاب الرواتب من ضرائب الدخل.
Prevalência de parasitos em bovinos abatidos em frigoríficos sob inspeção federal no estado de São Paulo de 2005 a 2017
Authors: Ortunho Vanessa Veronese , Silveira Paniéli Garcia , Silva Eduarda Aguiar Roberto Da , Cruz Adriano Pereira Da , Oliveira Bruno Hipólito Da Silva De , Biseo Esdras Natã , Pondian Wilian
Published: November 2024

A bovinocultura brasileira tem destaque nacional e internacionalmente, pois tem condições favoráveis para a produção de carne e derivados. Sabe-se que os parasitos podem ser encontrados em bovinos, causando condenação nos órgãos do animal. Por isso é essencial o serviço de inspeção sanitária. Porém, os investimentos para a identificação dos parasitos são poucos, pois muitas vezes eles só são observados na hora do abate o que acaba ocasionando as lesões nos órgãos. O trabalho teve como objetivos detectar o índice de parasitos presente nos órgãos de bovinos abatidos e determinar o local de maior incidência das lesões e avaliar a quantidade de animais abatidos no Brasil e em São Paulo. A realização do trabalho foi através da análise de fichas disponíveis no site do MAPA (Ministério da Agricultura, Pecuária e Abastecimento) durante o período de 2005 a 2017.Observou-se que nos anos estudados houve 308.277,103 bovinos abatidos no Brasil e 41.915,673 abatidos no Estado de São Paulo. O período avaliado mostrou a ocorrência de parasitos somente no fígado, intestino e pulmão apresentando um total de 3.994 lesões. O intestino foi o órgão mais lesionado com o total de 3.946 lesões e o pulmão com menor totalizando 5 lesões. Estas lesões mostram que há condenações pela presença de parasito, porém é baixa a sua prevalência, mostrando o quão é importante o produtor prevenir a ocorrência com o uso de anti-helmínticos.
Chemical characterization and biological activity assessment of Atriplex halimus essential oil: exploring new avenues in pharmacology and medicine
Authors: Rachida Kerzabi , Ahmed Aouadj Sid , Ilyas Chikhi , Khadidja Boussaid , Imène Lafri , Alain Muselli
Published: November 2024

The plant Atriplex halimus was the subject of the investigation. 99 volatile compounds were found in the essential oil after being analyzed by gas chromatography-mass spectrometry (GC-MS). The majority of these were E-anethole (13.9%), phytone (9.5%), carvone (6.0%), carvacrol (4.2%) and geranylacetone (3.0%). To assess the antioxidant potential of the essential oil, the 1,1-diphenyl-2-picrylhydrazyl (1,1-DPPH) and Ferric Reducing Antioxidant Power (FRAP) tests were performed. The results showed that Atriplex halimus essential oil has significant antioxidant potential as well as the ability to reduce iron, as indicated by absorbance (A). At a concentration of 3 mg/ml, the essential oil reduces the DPPH radical by a maximum of 51.12%. The concentration needed to reduce the DPPH radical by 50%, was determined to be 28.20 mg/ml. The essential oil did, exhibit stronger antioxidant activity at lower concentrations than ascorbic acid, but not at higher concentrations. The Minimum Inhibitory Concentration (MIC) dilution method was used to test the antibacterial effects of Atriplex halimus essential oils against nine different bacterial strains.
With an MIC range of 2.6 to 10.41 mg/ml and higher activity compared to gentamicin against some bacterial strains, the results demonstrated that the oils have significant antibacterial activity.
Are Controversies an Opportunity to Achieve Profitability? The Healthcare Sector Observation
Authors: Cunea Miruna Iuliana
Published: November 2024

Starting with climate changes, followed by the pandemic period and conflicts between states, companies have been encouraged to align their strategies to ensure business continuity. In addition to these tumultuous periods, sustainability reporting has often remained a relatively voluntary practice in many states. During the pandemic, newspapers highlighted numerous instances of corruption in the healthcare sector, highlighting concerns about how well companies were addressing community needs. This study aims to analyse the impact of controversies on the profitability of the healthcare sector companies and assess the opportunities that arise from reporting them. To investigate this, a sample of 1323 listed healthcare companies was used, and a quantitative analysis was conducted through statistical and econometric methods. Data were gathered from the Refinitiv Eikon Database covering the period 2020-2022 and included sustainability indicators such as ESG Controversies and ESG scores. ROA (Return on Assets) was used as the key profitability indicator. The study’s findings reveal that there are no significant opportunities aligned tied to controversies in the healthcare sector during crisis periods. Contrary, controversies negatively impacted the profitability of listed healthcare companies during crisis periods. The novelty of the study is reflected in the analysis of the ESG controversies indicator associated with the profitability of the healthcare sector during crisis periods.
The Significance of Responsible Leadership for Innovative Work Behaviour: A Conceptual Framework
Authors: Soukupová Nikola , Kotková Stříteská Michaela
Published: November 2024

Responsible leadership is a key foundation in today's dynamic business world, where the call for ethical behaviour and innovation is louder than ever. Unlike traditional leadership paradigms, responsible leadership represents a multifaceted relationship and views leadership as a dynamic interplay between leaders and stakeholders, rather than a one-sided leader-follower dynamic. Based on this understanding, our study developed a conceptual framework for the relationship between accountable leadership and innovative work behaviors. It also identified mediating-moderating roles to better understand the linkages and gaps in the research. The conceptual framework was developed based on a literature search of 82 studies. The individual constructs of the model were analysed with the findings of other studies and the theoretical and practical contribution was identified through synthesis. In order to create a sustainable future, it is imperative that the pursuit of continuous innovation and the principles of responsible behaviour form the cornerstones of any society. Responsible leadership stimulates innovative work behaviour not only for the benefit of the organisation but also for the well-being of all stakeholders. This is essential to building the relationships and corporate culture that mediate this relationship. The moderator of this relationship is the moral intelligence of the responsible leader, which strengthens the relationship between responsible leadership and innovative work behaviour. The study contributes by providing a comprehensive review of the existing knowledge on responsible leadership and innovative work behavior.  Furthermore, it enriches scholarly knowledge and offers practical insights into the characteristics desirable in CEOs to promote responsible and innovative business behavior.
Who is an Agile leader? Technological vs. Non-technological Mindset Employees' Views
Authors: Kucharska Wioleta , Kucharski Maciej , Balcerowski Tomasz , Jussila Jari
Published: November 2024

For an agile organization to be truly agile, it must be led by agile leaders to sustain its competitiveness and continuously identify opportunities for future growth and development. Technological and non-technological mindsets can see agile leadership differently. Therefore, this study aims to explore if there is any difference in the vision of who the agile leader is in the views of knowledge workers employed in the IT and other sectors. Using a qualitative definitional/interpretive approach supported by MAXQDA software, this study revealed that from the perspective of the technological mindset, key specific to this group characteristics are diligent risk management, technology usage focus, deep understanding of needs, efficiency, and efficacy, critical thinking skills, multitasking, information and knowledge sharing, responsibility, feeling, and constant focus on improvement. Whereas from the perspective of non-technological mindsets, key specific characteristics these mindsets notice are support for employee growth, dynamism and relevance of actions taken, perfect operation on managerial paradoxes, creativity, inclusion, empathy, and self-confidence. The common characteristics that are easy to notice in both mindset types are open-minded personality, the sequential habit of revisions, reflection, and re-framing, learning from experience, wise dynamic (smooth and accurate actions), perfect change implementation skills, adaptability skills, and a positive attitude towards challenges.
Goal Setting and the Emergence of the Safety-Efficiency Trade-off in Organizations
Authors: Rocchi Sara
Published: November 2024

This article aims to shed light on the trade-off between safety and efficiency that arises in organizations when management sets overly demanding efficiency goals. To explore the dynamics and relationships between management's goal setting and the safety-efficiency trade-off, we have chosen to analyze the extreme and illustrative case of the Herald of Free Enterprise disaster – a ferry that sank on March 6, 1987, resulting in the deaths of 193 passengers and crew members. The case shows how the management's imposition of very tight schedules for embarkation and disembarkation operations at the port of Zeebrugge promoted the emergence of risky practices, namely the regular violation of procedures by the crew. We argue that these violations, aimed at increasing the speed of operations to meet the time goals, were a central factor, though not the only one, in the etiology of the accident. The case provides evidence that when management sets overly strict performance goals, it directs employees' attention and efforts toward efficiency at the expense of safety. As a result, safety is compromised, leading to an increased risk of incidents, which can harm employees' health and cause economic and legal damage to the organization.