bluuebunny/crossref_metadata_2025 huggingface dataset:
Study on evaluation index system of sustainable development of mine water resources based on PSO-AHP model and fuzzy comprehensive evaluation
Authors: Liu Xiaomin , Liu Haiyan , Wan Zheng , Wang Lifei , Chen Qiong
Published: January 2021

Water resources is an important basic energy. The determination of weights is one of the important indexes in water resources evaluation system and reasonable allocation of weights is the key to quantitative evaluation. In order to establish a scientific evaluation index system of the influence of mining disturbance on water resources for purpose of a more reliable and effective evaluation result and realizing the protection of water resources system, a comprehensive evaluation system of water resources based on PSO-AHP model is proposed in the paper. Combined with the specific geological environment characteristics of mines, this paper establishes a four-level evaluation index system after identifying the factors affecting water resources and ecological environment. By applying the particle swarm optimization (PSO) to the analytic hierarchy process (AHP) and fuzzy comprehensive evaluation method, a PSO-AHP model and then a fitness function are constructed to solve and optimize the weight values in the evaluation index system, and the calculated weight values are checked by consistency checking method. The evaluation results suggest that the index system can accurately reflect the impact of mining on water resources and water ecological environment and etc., providing certain reference value for sewage resourcing and reducing the harmful effect on environment by sewage discharge.
An intelligent fault diagnosis method based on curve segmentation and SVM for rail transit turnout
Authors: Ji Wenjiang , Cheng Chen , Xie Guo , Zhu Lei , Wang Yichuan , Pan Long , Hei Xinhong
Published: January 2021

With the development of intelligent transportation system, the maintenance of railway turnout is an essential daily task which was required to be efficiency and automatically. This paper presents an intelligent diagnosis method based on deep learning curve segmentation and the Support Vector Machine. Firstly, we studied the curve segmentation approach of the real-time monitoring power data collected form turnout, for which is an essential step and do a great help to improve the diagnose accuracy. Then based on the well pre-processed data sets, the SVM algorithm was applied to classify the samples and report the health states of the turnout which under testing. At last, the experiments were taken on the power data curve collected from the real turnouts, during which we compared the new diagnose method with conventional ones, and the results showed that the diagnose accuracy of proposed method can averaged to 98.5%. Compared with traditional SVM based frameworks, the proposed diagnosis method dramatically improves the accuracy which is more suitable for railway turnout.
An intelligent diagnosis model of accidents in nuclear power plant
Authors: Liu Yanqi , Zhang Li , Xu Zhenghua , Liu Xueyang
Published: January 2021

This essay focus on the situation when the operator of the main control room can not handle the accident in time or make wrong judgment under accident condition in nuclear power plant, which may lead to the occurrence of major accidents or even more accidents concurrently. An intelligent fuzzy diagnosis model based on Grey Relational degree is constructed in this paper, by establishing accident-state correlation matrix and accident-state probability matrix, defining the vector of information weights for accident characteristic vector and monitoring result vector with linear transform, using Grey Relation to measure the relevance degree between monitoring result vector and accident characteristic vector, Searching for suspected accidents approaching to real solutions in iterative recursive algorithms, realizing automatic fuzzy diagnosis of multiple accidents. The results of simulation experiments of LOCA accidents indicate that the model and algorithm can diagnose various common accidents accurately and rapidly in complex nuclear power systems, providing strategy for operator’s diagnosis decision.
Research on outdoor AGV precise navigation based on BDS/INS data fusion
Authors: Tang Yongwei , Hao Huijuan , Zhou Jun , Lin Yuexiang , Dong Zhenzhen
Published: January 2021

AGV (Automated Guided Vehicle) technology has attracted increasing attention. Precise control of AGV position and attitude information in complex operating environment is a key part of smart factories. With outdoor AGV as a platform, this study uses BDS/INS combined navigation system combining Beidou positioning system and inertial navigation system and takes the velocity and position difference between BDS and INS as a model. An integrated navigation method is proposed to improve bee colony algorithm and optimize the BP neural network-assisted Kalman filtering to achieve accurate positioning. Moreover, the optimization of BP neural network navigation using INS navigation, network-assisted navigation and bee colony algorithm is simulated. Results demonstrate that the integrated navigation algorithm has effectiveness and feasibility, and can solve the problems of BDS misalignment and large INS navigation error in complex environments.
Research on detection algorithm of lithium battery surface defects based on embedded machine vision
Authors: Chen Yonggang , Shu Yufeng , Li Xiaomian , Xiong Changwei , Cao Shenyi , Wen Xinyan , Xie Zicong
Published: January 2021

In the production process of lithium battery, the quality inspection requirements of lithium battery are very high. At present, most of the work is done manually. Aiming at the problem of large manual inspection workload and large error, the robot visual inspection technology is applied to the production of lithium battery. In recent years, with the rapid development and progress of science and technology, the rapid development of visual detection hardware and algorithms, making it possible to screen defective products through visual detection algorithms. This paper takes lithium battery as the research object, and studies its vision detection algorithm. As a common commodity, the quality of lithium battery is the key for users to choose. With the increasing requirements of users for battery quality, how to produce high-quality battery is the key problem to be solved by manufacturers. However, at present, the defects of battery surface are mostly carried out manually. There are low efficiency and low detection rate in the process of manual detection. In this paper, the visual detection algorithm is studied to detect the defects such as pits, rust marks and broken skin on the surface of lithium battery, specifically to design the imaging experimental platform of lithium battery; use different lighting schemes to design different battery positioning and extraction algorithms; use Hough detection method to locate the battery surface, and design the battery defect algorithm for this, and compare the algorithm through experiments.
A parallel biological computing algorithm to solve the vertex coloring problem with polynomial time complexity
Authors: Wang Zhaocai , Wang Dangwei , Bao Xiaoguang , Wu Tunhua
Published: January 2021

The vertex coloring problem is a well-known combinatorial problem that requires each vertex to be assigned a corresponding color so that the colors on adjacent vertices are different, and the total number of colors used is minimized. It is a famous NP-hard problem in graph theory. As of now, there is no effective algorithm to solve it. As a kind of intelligent computing algorithm, DNA computing has the advantages of high parallelism and high storage density, so it is widely used in solving classical combinatorial optimization problems. In this paper, we propose a new DNA algorithm that uses DNA molecular operations to solve the vertex coloring problem. For a simple n-vertex graph and k different kinds of color, we appropriately use DNA strands to indicate edges and vertices. Through basic biochemical reaction operations, the solution to the problem is obtained in the O (kn2) time complexity. Our proposed DNA algorithm is a new attempt and application for solving Nondeterministic Polynomial (NP) problem, and it provides clear evidence for the ability of DNA calculations to perform such difficult computational problems in the future.
Fusing appearance and motion information for action recognition on depth sequences
Authors: Pei Cong , Jiang Feng , Li Mao
Published: January 2021

With the advent of cost-efficient depth cameras, many effective feature descriptors have been proposed for action recognition from depth sequences. However, most of them are based on single feature and thus unable to extract the action information comprehensively, e.g., some kinds of feature descriptors can represent the area where the motion occurs while they lack the ability of describing the order in which the action is performed. In this paper, a new feature representation scheme combining different feature descriptors is proposed to capture various aspects of action cues simultaneously. First of all, a depth sequence is divided into a series of sub-sequences using motion energy based spatial-temporal pyramid. For each sub-sequence, on the one hand, the depth motion maps (DMMs) based completed local binary pattern (CLBP) descriptors are calculated through a patch-based strategy. On the other hand, each sub-sequence is partitioned into spatial grids and the polynormals descriptors are obtained for each of the grid sequences. Then, the sparse representation vectors of the DMMs based CLBP and the polynormals are calculated separately. After pooling, the ultimate representation vector of the sample is generated as the input of the classifier. Finally, two different fusion strategies are applied to conduct fusion. Through extensive experiments on two benchmark datasets, the performance of the proposed method is proved better than that of each single feature based recognition method.
Data-driven approach to identify obsolete functions of products for design improvements
Authors: Zhao Zhihua , Li Yupeng , Chu Xuening
Published: January 2021

Identifying defective design elements is a prerequisite for design improvements. Previous identification methods were implemented in the context of static customer requirements (CRs). However, CRs always evolve continuously, which easily leads to a failure of existing product functions in fulfilling customer expectations; this, in turn, can lead to a decline in customer satisfaction. In this study, the phenomenon is termed as ‘function obsolescence’, and a data-driven identification approach for obsolete functions is proposed for design improvements. Firstly, product operating data are employed to construct the observing parameters of functional performance (OPs), and based on the distribution of OPs, the desired level of functional performance (DL) is defined to quantitatively characterise CRs. Secondly, the time series of DL is constructed to embody the evolution of CRs, in which a Sigmoid-like function is employed to establish a dissatisfaction function. With the time series, an obsolescence index measuring the severity of obsolescence for each function is defined to identify obsolete functions. A case study was implemented on a smart phone to identify its obsolete functions to demonstrate the effectiveness of the proposed methodology. The results show that some potentially obsolete functions can be identified by the proposed method considering the evolution of CRs.
A New Era: The Growth of Video-Based Visits for Remote Management of Persons with Parkinson’s Disease
Authors: Larson Danielle N. , Schneider Ruth B. , Simuni Tanya
Published: January 2021

The COVID-19 pandemic forced the abrupt and rapid expansion of an alternative care model that embraces the use of video-based visits in the care of persons with Parkinson’s disease. Video-based visits not only eliminate the risk of infection but also reduce geography- and disability-related barriers to accessing specialist care. Research has established that they are feasible, acceptable to persons with Parkinson’s disease and patient-centered. In the Unites States, the relaxation of licensure requirements, adoption of reimbursement parity and investment in telemedicine infrastructure has enabled the rapid growth of video-based visits during the COVID-19 pandemic. Now, we must turn our attention to ensuring that progress made in expanding access to video-based care is not lost and expanded worldwide. More work is needed to identify the optimal video-based care model, establish best practices, and ensure equitable access to care.
A static sound source can improve postural stability during walking
Authors: Anton Kristina , Ernst Arne , Basta Dietmar
Published: January 2021

BACKGROUND: During walking, postural stability is controlled by visual, vestibular and proprioceptive input. The auditory system uses acoustic input to localize sound sources. For some static balance conditions, the auditory influence on posture was already proven. Little is known about the impact of auditory inputs on balance in dynamic conditions. OBJECTIVE: This study is aimed at investigating postural stability of walking tasks in silence and sound on condition to better understand the impact of auditory input on balance in movement. METHODS: Thirty participants performed: walking (eyes open), tandem steps, walking with turning head and walking over barriers. During each task, acoustic condition changed between silence and presented noise through an earth-fixed loudspeaker located at the end of the walking distance. Body sway velocity was recorded close to the body’s center of gravity. RESULTS: A decreased body sway velocity was significant for walking (eyes open), tandem steps and walking over barriers when noise was presented. Those auditory stimuli did not affect sway velocity while walking with turning head. The posture has probably improved due to the localization ability when walking with the head facing forward, while the localization ability was impaired when turning the head. CONCLUSIONS: The localization ability of a fixed sound source through the auditory system has a significant but limited impact on posture while walking.
Demographic predictors of resilience among nurses during the COVID-19 pandemic
Authors: Afshari Davood , Nourollahi-darabad Maryam , Chinisaz Niloofar
Published: January 2021

Background: Coronavirus disease 2019 (COVID-19) is mostly transmitted through respiratory droplets. One of the exposure methods pf this disease is through occupational exposures and, thereby, a large number of people are prone to catching this disease due to their occupations. Nurses during the COVID-19 pandemic are at the forefront of healthcare. There is no information about the level of resilience and the demographic and job factors predicting resilience in the critical conditions of this occupational group. Objective: The present study aims to determine the resilience score and its predictive demographic factors among the nurses working at the hospitals involved with COVID-19 in Ahvaz, Iran. Methods: 387 nurses from Ahvaz hospitals participated in this study. The Connor-Davidson Resilience Scale (CD-RISC) was used to assess resilience. Demographic information was also collected using a designed questionnaire. Since the present study was conducted during the COVID-19 pandemic, the questionnaires were sent online. Data were entered into software SPSS (version 23) and T-test, ANOVA and regression methods were used for data analysis. Results: The mean score of 61.18 (±14.8) was obtained for CD-RISC. The results of this study showed that age (r = 0.610, P = 0.003), work experience (r = 0.572, P = 0.030), and level of education (r = 0.514, P = 0.044) had a significant positive correlation with nurses’ resilience score during the COVID-19 pandemic. Multiple regression analysis indicated that work experience and level of education were the predictors of nurses’ resilience (R2 = 0.15). Conclusion: The score of nurses’ resilience was low. Based on the results, education and work experience were determined as the contributing factors for resilience. The findings can help to better understand effective and predictive demographic factors to achieve higher resilience in stressful situations.
Transfer of ergonomics knowledge from participatory simulation events into hospital design projects
Authors: Andersen Simone Nyholm , Broberg Ole
Published: January 2021

BACKGROUND: Participatory simulation (PS) is a method that can be used to integrate ergonomics and safety into workplace design projects. Previous studies have mainly focused on tools and methods for the simulation activities. The subsequent process of transferring and integrating the simulation outcomes into the design of workplaces is poorly understood. OBJECTIVE: This study sets out to study the role of actors and objects in the transfer of ergonomics knowledge generated in PS events and in the integration of this knowledge into a design project. The study identifies factors that influence what part of the simulation outcomes are integrated. METHODS: The empirical context of the study was six PS events that were part of a hospital design project. The events were investigated based on knowledge transfer theory, observations, interviews and document studies. RESULTS: Actors and objects with abilities of transferring ergonomics knowledge from the PS events to the hospital design project were identified. The study indicated that persons producing the objects functioned as a filter, meaning that not all ergonomics knowledge was transferred from the PS events. The main influencing factors on the integration were: predetermined building dimensions and room interdependency. CONCLUSIONS: Four recommendations were proposed for ergonomists and safety professionals when planning PS events.
The value of occupational therapy intervention for the worker roles of forensic mental healthcare users in Cape Town, South Africa
Authors: Soeker Mogammad Shaheed , Hare Saabirah , Mall Saadia , van der Berg Jean
Published: January 2021

BACKGROUND: There is a void in research that focuses on how OT programs facilitate self-esteem in forensic mental healthcare users’ return-to-work in the open labor market, particularly in South Africa. OBJECTIVE: To explore the experiences and perceptions of forensic mental healthcare users, transitioning from an OT program to the open labor market. METHODS: Five individuals, diagnosed with Schizophrenia, and two key informants participated in this study that was positioned in a qualitative paradigm, with an exploratory and descriptive design. Semi-structured interviews were used to collect data. RESULTS: Theme one reflects on the challenges experienced by forensic mental healthcare users, when returning to work. Theme two describes various OT programs, as well as how they facilitate the reintegration of forensic mental healthcare users into the worker role. Theme three describes the positive support for forensic mental healthcare users, in the mental healthcare setting, workplace, and the greater community. Theme four describes how participation in occupation installs hope in forensic mental healthcare users, reinforcing the value of work, while positively influencing their work identity. CONCLUSION: The results revealed that stigma, residual symptoms, relapse due to substance abuse/mental health, and the lack of family support, were not be conducive to work skills development. However, the support of family and friends, workplace occupational therapy support, assembly line work, and therapeutic groups in an OT program, ensured positive workplace reintegration.
Analysis of physical and physiological workloads of nursing in the surgical center
Authors: Chomem Paula , Motter Arlete Ana
Published: January 2021

BACKGROUND: Operating room nursing professionals are exposed to different workload. It is necessary to recognize which situations resulting from their tasks interfere with the health of the professional. OBJECTIVES: We aimed to identify the physical and physiological loads on operating room nurses and their impact on the health as well as trace ergonomic recommendations based on the literature and performed analysis. METHODS: The is an exploratory, observational, descriptive research conducted in the surgical center of a university hospital between August 2017 and July 2018. Nursing staff of both genders who worked as transport professionals or room circulators were included in the study. Data collection in the OR went through stages of Ergonomic Workplace Analysis (EWA), through semi-structured interviews addressing the physical and physiological work issues and a worksheet of data collected from the observations of the practitioners’ actions. RESULTS: The study included 20 nursing workers of both genders with an average of 17.33±12.58 years of work experience. The most reported problematic factors were: lack of material, staff pressure, patient transporting, employment legal status with the institution, and lack of communication among the practitioners. CONCLUSIONS: There was a physical effort during the activity and a high prevalence of workers with pain complaints, which justifies the investigation.
DIVERS PERCEPTIONS AND IMPLICATIONS FOR SUSTAINABLE TOURISM MANAGEMENT IN THE CEARÁ STATE COAST, BRAZIL
Authors: Pantalena Ana Flavia , Soares Marcelo de Oliveira , Rodrigues Luis Campos
Published: January 2021

The analysis of the perceptions of divers can be a useful tool for developing sustainable tourism. Despite its importance, there is still little understanding of the role of perceptions of environmental and infrastructure problems in the improvement of diving tourism in developing countries. This study assesses the perceptions of 140 divers regarding different diving sites in the Ceará State Coast, northeastern Brazil. The results indicate that, despite the existence of 32 diving sites, only the Marine Protected Area (MPA) was regularly visited. This area was classified as “good/very good” in terms of its marine biodiversity. One of its particularities is the presence of reef environments. The divers gave the boats, and the operations of embarking and disembarking a “bad/poor” rating. Moreover, travel times and the presence of marine litter and abandoned fishing nets were considered as “reasonable/medium”. Finally, this study discusses various strategies for preserving tropical marine biodiversity and maximizing the enjoyment of divers. These include the monitoring of illegal fishing, implementing the management plan of MPA, and improvements to the diving infrastructure. Understanding the preferences of recreational divers regarding dive experiences can strengthen sustainable tourism and be of great importance to the support of public policies and coastal management. Keywords: diving tourism, coastal management, marine protected areas, coastal tourism.
PROCESSOS FLUVIOMARINHOS ASSOCIADOS À FORMAÇÃO DA ILHA RASA, SUL DA BAÍA DE MARAPATÁ, NORDESTE DO PARÁ, BRASIL
Authors: Rodrigues Ribeiro Samuel , Célio Valadão Roberto
Published: January 2021

As ilhas assumem expressivo destaque na paisagem estuarina paraense; contudo, a maior parte delas apresenta gênese não claramente definida. A fim de investigar os fatores de formação da ilha Rasa, situada na foz do rio Tocantins, estuário do rio Pará, o presente trabalho se apoia em feições sedimentares identificadas em um testemunho de sedimento coletado no interior da ilha. Neste trabalho, a integração faciológica e a interpretação de seus ambientes deposicionais, em associação aos eventos climáticos reportados para a região, subsidiaram a proposição de modelo morfogenético. O modelo aqui proposto sugere que a ilha Rasa possui idade tardio-holocênica e consistia, incialmente, de barras arenosasque evoluíram sob o efeito de processos fluviais, inerentes à rede de drenagem e marinhos, articulados às mudanças no clima e nível do mar. Esses processos afetaram o suprimento de sedimento e a distribuição da cobertura vegetal, influenciando a configuração do setor estuarino e contribuindo para a formação de ilhas proximais.
Palavras-chave: barra arenosa, estuário, nível relativo do mar, ambiente sedimentar, rioTocantins.
Leadership, Work Spirituality, Competence and Loyalty to Employee Performance
Authors: ADIPUTRA PUTU DONNY NOVARIANA
Published: January 2021

This study aims to analyze the role of leadership, work spirituality, competence, and loyalty to employee performance. The respondents involved were 86 employees who worked at PT. Bank Pembangunan Daerah Bali Karangasem Branch. The study was conducted by census. This study employed descriptive analysis to determine the number, percentage, and average of respondents’ answers. Additionally, this study also used inferential analysis by evaluating the measurement model (outer model) and the structural model (inner model). The results indicate that leadership had a positive and significant effect on job satisfaction and employee performance. Leadership and spirituality had a positive and significant influence on work loyalty. Besides, competence and loyalty had a positive and significant effect on employee performance. However, in this study, competence, leadership, and spirituality did not show a significant effect on employee performance.
HOSPITALITAS KRISTEN DAN TANTANGANNYA DI TENGAH PANDEMI COVID-19
Authors: Panuntun Daniel Fajar , Paramita Eunike
Published: January 2021

ABSTRACT
The global world at the end of 2019 was shocked by a pandemic caused by the Corona Virus. Corona Virus Disease 2019 raises global concerns about the rapid and deadly spread. Indonesia has also been affected by the Covid-19 case and dated March 19, 2020 there have been 309 positive cases and still counting. The government promotes social distancing policies to reduce publicity in order to minimize the development of Covid-19. Indonesian people are responding to this recommendation, but there are some who do panic buying, persecution of health workers who have the possibility of exposure to Covid-19  and other cases that show the loss of hopitality of Indonesian citizens. This paper aims to formulate an ethical model of Christian hopitality in the midst of the Covid-19  Pandemic. This study uses a qualitative approach to theological research and social descriptive research. The results of this study consist of three main points, namely: first, Christianity must not lose empathy as an attitude of Christian hopitality in every lifetime. Second, the attitude of hopitalitas must look at the context ethically, namely the context of the distribution of Covid-19. Third, Christian hopitality has risks and impacts in the form of its implementation amid the Covid-19 pandemic.
Key Words: Ethical Decisions, Hospitality, Christianity, covid-19.
Using Bootstrap to Increase Data in Predictive Analytics with Extreme Value Distribution
Authors: Cuong Dang Kien , Dam Duong Ton , Duong Duong Ton Thai
Published: January 2021

The bootstrap is one of the method of studying statistical math which this article uses it but is a major tool for studying and evaluating the values of parameters in probability distribution. Overview of the theory of infinite distribution functions. The tool to deal with the problems raised in the paper is the mathematical methods of random analysis by theory of random process and multivariate statistics. Observations (realisations of a stationary process) are not independent, but dependence in time series is relatively simple example of dependent data. Through a simulation study we found that the pseudo data generated from the bootstrap method always showed a weaker dependence among the observations than the time series they were sampled from, hence we can draw the conclusion that even by re-sampling blocks instead of single observations we will lose some of structural from of the original sample. A potential difficulty by the using of likelihood methods for the GEV concerns the regularity conditions that are required for the usual asymptotic properties associated with the maximum likelihood estimator to be valid. To estimate the value of a parameter in GEV we can use classical methods of mathematical statistics such as the maximum likelihood method or the least squares method, but they all require a certain number samples for verification. For the bootstrap method, this is obviously not needed; here we use the limit theorems of probability theory and multivariate statistics to solve the problem even if there is only one sample data. That is the important practical significance that our paper wants to convey. In predictive analysis problems, in case the actual data is incomplete, not long enough, we can use bootstrap to add data.
The Influence of an Elevated Production of Extracellular Enveloped Virions of the Vaccinia Virus on Its Properties in Infected Mice
Authors: Shchelkunov S. N. , Yakubitskiy S. N. , Bauer T. V. , Sergeev A. A. , Kabanov A. S. , Bulichev L. E. , Yurganova I. A. , Odnoshevskiy D. A. , Kolosova I. V. , Pyankov S. A. , Taranov O. S.
Published: January 2021

The modern approach to developing attenuated smallpox vaccines usually consists in targeted inactivation of vaccinia virus (VACV) virulence genes. In this work, we studied how an elevated production of extracellular enveloped virions (EEVs) and the route of mouse infection can influence the virulence and immunogenicity of VACV. The research subject was the LIVP strain, which is used in Russia for smallpox vaccination. Two point mutations causing an elevated production of EEVs compared with the parental LIVP strain were inserted into the sequence of the VACV A34R gene. The created mutant LIVP-A34R strain showed lower neurovirulence in an intracerebral injection test and elevated antibody production in the intradermal injection method. This VACV variant can be a promising platform for developing an attenuated, highly immunogenic vaccine against smallpox and other orthopoxvirus infections. It can also be used as a vector for designing live-attenuated recombinant polyvalent vaccines against various infectious diseases.
Modification of Nuclear Compartments and the 3D Genome in the Course of a Viral Infection
Authors: Razin S. V. , Gavrilov A. A. , Iarovaia O. V.
Published: January 2021

The review addresses the question of how the structural and functional compartmentalization of the cell nucleus and the 3D organization of the cellular genome are modified during the infection of cells with various viruses. Particular attention is paid to the role of the introduced changes in the implementation of the viral strategy to evade the antiviral defense systems and provide conditions for viral replication. The discussion focuses on viruses replicating in the cell nucleus. Cytoplasmic viruses are mentioned in cases when a significant reorganization of the nuclear compartments or the 3D genome structure occurs during an infection with these viruses.
The Delivery of Biologically Active Agents into the Nuclei of Target Cells for the Purposes of Translational Medicine
Authors: Sobolev A. S.
Published: January 2021

Development of vehicles for the subcellular targeted delivery of biologically active agents is very promising for the purposes of translational medicine. This review summarizes the results obtained by researchers from the Laboratory of Molecular Genetics of Intracellular Transport, Institute of Gene Biology RAS, which allowed them to design the core technology: modular nanotransporters. This approach ensures high efficacy and cell specificity for different anti-cancer agents, as they are delivered into the most vulnerable subcellular compartment within the cells of interest and makes it possible for antibody mimetics to penetrate into a compartment of interest within the target cells (diving antibodies). Furthermore, polyplexes, complexes of polycationic block copolymers of DNA, have been developed and characterized. These complexes are efficient both in vitro and in vivo and demonstrate predominant transfection of actively dividing cells.
Drosophila Zinc Finger Protein CG9890 Is Colocalized with Chromatin Modifying and Remodeling Complexes on Gene Promoters and Involved in Transcription Regulation
Authors: Fursova N. A. , Mazina M. Y. , Nikolenko J. V. , Vorobyova N. E. , Krasnov A. N.
Published: January 2021

In this work, we conducted a genome-wide study of the zinc finger protein CG9890 and showed that it is localized mostly on the promoters of active genes. The CG9890 binding sites are low-nucleosome-density regions and are colocalized with the chromatin modifying and remodeling complexes SAGA and dSWI/SNF, as well as with the ORC replication complex. The CG9890 protein was shown to be involved in the regulation of the expression of some genes on the promoters of which it is located, with the ecdysone cascade genes accounting for a significant percentage of these genes. Thus, the CG9890 protein is a new member of the transcriptional network which is localized on active promoters, interacts with the main transcription and replication complexes, and is involved in the regulation of both basal and inducible transcription.
Polycomb and Trithorax Group Proteins: The Long Road from Mutations in Drosophila to Use in Medicine
Authors: Chetverina D. A. , Lomaev D. V. , Erokhin M. M.
Published: January 2021

Polycomb group (PcG) and Trithorax group (TrxG) proteins are evolutionarily conserved factors responsible for the repression and activation of the transcription of multiple genes in Drosophila and mammals. Disruption of the PcG/TrxG expression is associated with many pathological conditions, including cancer, which makes them suitable targets for diagnosis and therapy in medicine. In this review, we focus on the major PcG and TrxG complexes, the mechanisms of PcG/TrxG action, and their recruitment to chromatin. We discuss the alterations associated with the dysfunction of a number of factors of these groups in oncology and the current strategies used to develop drugs based on small-molecule inhibitors.
The DPF Domain As a Unique Structural Unit Participating in Transcriptional Activation, Cell Differentiation, and Malignant Transformation
Authors: Soshnikova N. V. , Sheynov A. A. , Tatarskiy Eu. V. , Georgieva S. G.
Published: January 2021

The DPF (double PHD finger) domain consists of two PHD fingers organized in tandem. The two PHD-finger domains within a DPF form a single structure that interacts with the modification of the N-terminal histone fragment in a way different from that for single PHD fingers. Several histone modifications interacting with the DPF domain have already been identified. They include acetylation of H3K14 and H3K9, as well as crotonylation of H3K14. These modifications are found predominantly in transcriptionally active chromatin. Proteins containing DPF belong to two classes of protein complexes, which are the transcriptional coactivators involved in the regulation of the chromatin structure. These are the histone acetyltransferase complex belonging to the MYST family and the SWI/SNF chromatin-remodeling complex. The DPF domain is responsible for the specificity of the interactions between these complexes and chromatin. Proteins containing DPF play a crucial role in the activation of the transcription of a number of genes expressed during the development of an organism. These genes are important in the differentiation and malignant transformation of mammalian cells.
Numerical Study of the Heat Transfer Characteristics of Convection in Vertical Channel through FEM Simulation
Authors: Reddy P. V. Janardhana
Published: January 2021

An attempted is made on the free convection flow of an incompressible viscous fluid in the profile in terms of heat characteristics were analyzed. The flow is assumed to be along the axis of the channel. The uniform temperature is considered in the study. The momentum conservation equations for the fully developed flow are based on the Brinkman model. The viscous and Darcy dissipation are taken into account in the energy equation as the modification of the heat flow. By using the finite element method, the fluid and the porous matrix are in local thermal equilibrium and the flow is unidirectional along the direction of the buoyancy. The non-linear equations governing the flow, heat and mass transfer have been analyzed. Various parameters such as the velocity, temperature, concentration, Nusselt number, and Sherwood number are analyzed and their behavior is interpreted in the paper.
Drenagem Linfática Manual em Pacientes Oncológicos: Quais as Evidências Científicas e as Recomendações Clínicas?
Authors: Bergmann Anke , Baiocchi Jaqueline Munaretto Timm , Rizzi Samantha Karlla Lopes de Almeida , Allende Ruy Gonzalo Martinez
Published: January 2021

O artigo tem como objetivo discutir a realização da DLM na prevenção e tratamento das complicações advindas das intervenções oncológicas e da evolução do câncer. Espera-se que tal artigo de opinião possa contribuir na decisão do fisioterapeuta em realizar ou não a DLM em cada situação da prática clínica.
Avaliação da Percepção do Paladar de Pacientes Oncológicos: Relação com Variáveis Pessoais e Clínicas e Comparação com um Grupo Controle
Authors: Maniglia Fabíola Pansani , Cruz Leonice Caldeira da , Costa Lauane Cristina Marques , Silva Lara Coelho de Oliveira , Oliveira Bruno Affonso Parenti de
Published: January 2021

Introdução: O tratamento antineoplásico pode causar efeitos colaterais que prejudicam a ingestão alimentar e o estado nutricional dos pacientes. Objetivo: Avaliar a percepção do paladar de pacientes em tratamento oncológico, relacioná-la com as variáveis pessoais e clínicas e compará-la com a percepção do paladar de indivíduos sadios. Método: Trata-se de um estudo transversal com 50 indivíduos em tratamento oncológico e outros 50 indivíduos do grupo controle. Para avaliar a percepção do paladar, os participantes receberam amostras de alimentos e foram questionados quanto aos sabores doce, amargo, salgado e azedo. A intensidade do sabor foi avaliada por meio de uma escala de 1 a 5. Resultados: Os pacientes em tratamento oncológico perceberam os sabores dos seguintes alimentos de maneira mais acentuada: doce de leite (4,48±1,0 vs. 3,78±0,9; p<0,05), goiabada (4,10±1,0 vs. 3,52±0,9; p<0,05), suco de limão (4,42±0,9 vs. 2,86±1,0; p<0,05), suco de maracujá (3,76±1,2 vs. 2,56±1,0; p<0,05) e café (4,42±0,8 vs. 3,14±0,9; p<0,05). Já os alimentos: biscoito de polvilho, iogurte natural, rúcula e chicória foram percebidos com menor intensidade quando comparados ao grupo controle. Entre as quatro categorias de sabor avaliadas, os alimentos do grupo salgado foram os que menos se diferenciaram quanto à percepção do paladar e os alimentos azedos e amargos foram percebidos de forma mais distinta entre os grupos. Conclusão: O presente estudo é pioneiro em avaliar a percepção do paladar utilizando alimentos, ao invés de soluções padronizadas; e, por meio dessa técnica, identificaram-se diferenças significativas na intensidade da percepção do paladar dos indivíduos em tratamento oncológico.
Demonstrações dos sentimentos, objetos e atividades de estudantes do Ensino Médio de Manaus/AM, durante a pandemia da COVID-19, por meio de desenhos
Authors: Oliveira Hebe Souza de , Petersen Thiago Alexandre
Published: January 2021

O novo coronavírus mudou radicalmente a rotina das pessoas em todo o planeta e do dia para a noite. Por causa da pandemia, as aulas presenciais foram temporariamente suspensas em escala global. No Brasil, as aulas presenciais também foram interrompidas como medida de segurança. Manaus foi umas das capitais mais afetadas pela COVID-19, com alto percentual de mortalidade. Mas, apesar disso, a cidade foi uma das primeiras do país a retornar com as aulas presenciais para os estudantes do ensino médio. Diante disso, surge a pergunta, o que os estudantes fizeram durante a pandemia? Usando desenhos autorais, esta pesquisa verificou os objetos, as atividades e os sentimentos mais enfatizados pelos estudantes do ensino médio durante a pandemia. Nesta pesquisa foram analisados 141 desenhos, feitos como uma atividade da disciplina “Arte”, em duas escolas da rede pública de Manaus, capital do Estado do Amazonas, Brasil. Os desenhos foram analisados pelo método da análise de conteúdo. Os objetos mais destacados foram a TV, a cama e o celular. Dessa maneira, as atividades mais ressaltadas foram assistir à TV, dormir, e usar o celular. Cerca de 40% dos estudantes demonstraram dividir bem seu tempo em casa e fazer várias atividades. Entretanto, aproximadamente 60% dos estudantes demonstraram dificuldades em aproveitar produtivamente seu tempo. Os sentimentos mais frequentes foram negativos, como: confusão, insegurança, ansiedade, solidão, medo e depressão. Os sentimentos positivos mais frequentes foram: a afeição aos animais e o amor de namorados. Em cerca de 20% dos desenhos, pode-se observar referências a COVID-19, além de medidas de preventivas. Concluiu-se que os estudantes foram afetados pela pandemia, a maior parte teve dificuldade em organizar sua rotina e distribuir bem o seu tempo. Além disso, os sentimentos mais destacados foram negativos, o que mostrou que muitos estudantes ainda sentem medo e insegurança diante da COVID-19.
Upaya mengatasinya perilaku perundungan pada usia remaja
Authors: Tang Indo , Supraha Wido , Rahman Imas Kania
Published: January 2021

The purpose of this study was to determine the characteristics of victims of bullying in adolescence and various efforts to overcome bullying. The research method used is qualitative research with data collection using field research. The research was conducted in two places. The first research is at Full Day school, SMPIT Ummul Quro Bogor, and the second research is in a boarding school, namely SMP Integral Hidayatullah Depok. The data were obtained by conducting interviews with students, counseling teachers and school principals. This study found several characteristics of victims of bullying and efforts to overcome bullying behavior from the aspects of prevention, supervision and guidance (to perpetrators and victims).

Abstrak

Tujuan penelitian ini adalah untuk mengetahui ciri-ciri korban perundungan pada usia remaja dan berbagai upaya mengatasi perundungan. Metode penelitian yang digunakan adalah penelitian kualitatif dengan pengumpulan data menggunakan penelitian lapangan. Penelitian dilakukan di dua tempat. Penelitian pertama yaitu di sekolah Full Day, SMPIT Ummul Quro Bogor, dan penelitian kedua yaitu di sekolah berbasis pesantren (boarding School) yaitu SMP Integral Hidayatullah Depok.  Data diperoleh dengan melakukan wawancara kepada siswa, guru BK dan kepala sekolah. Penelitian ini menemukan beberapa ciri-ciri korban perundungan dan upaya mengatasi perilaku perundungan dari aspek pencegahan, pengawasan serta pembinaan (kepada pelaku dan korban).
Drip irrigation technology for potatoes through applying low-pressure semistationary small-capacity
Authors: Domullodzhanov Daler
Published: January 2021

The article describes the results of field and laboratory experiments on the study of the technology of drip irrigation of potatoes via using the semi-stationary low-pressure small-capacity drip irrigation system (LDIS) developed by us. Reinforced aluminium micro-tubes ensure uniform watering. Depending on the annual precipitation sufficiency, the potatoes irrigation requirements 1700…3400 m3/ha, the number of irrigations varied from 10 to 20 times, and the yield was between 54…58,2 tons per ha.
Anomalías congénitas en familias de ararca (isla de barú). bolívar-colombia
Authors: Espitia Almeida Fabián , Ospina Mateus Laura , Mora García Gustavo , Gómez Camargo Doris , Malambo García Dacia
Published: January 2021

Introducción: las enfermedades genéticas y los defectos de nacimiento son considerados problemas de salud pública a nivel mundial, con una incidencia de alrededor del 1%. Las principales complicaciones clínicas de estas enfermedades se caracterizan por comprometer la calidad de vida de los afectados, causando una grave discapacidad intelectual o física, por su carácter progresivo y condicionan una mortalidad precoz de los individuos afectados y generan una carga en las familias de las personas que las padecen.Objetivo: caracterizar las familias que reporten personas con anomalías congénitas que se puedan catalogar como genéticas, incluyendo el componente socioeconómico.Materiales y métodos: se planteó una metodología descriptiva, observacional y se analizaron algunos aspectos genéticos, como historia clínica genética y citogenética; se incluyeron variables socioeconómicas de una comunidad rural que previamente evidenció la presentación de enfermedades genéticas.Resultados: se reportaron cinco casos de personas con enfermedades congénitas y con indicación de trastorno genético, tres casos pertenecían a una misma familia; se analizóel componente sociodemográfico. Se evidenció un estado de pobreza de las familias, nivel educativo bajo en la mayoría, y casos de analfabetismo. Salarios que no alcanzan el mínimo, hacinamiento de las personas en las viviendas y relaciones intrafamiliares quebradas, evidente apatía entre los integrantes de las familias estudiadas.Conclusión: esta investigación permitió verificar en la comunidad de Ararca cinco casos de trastornos genéticos que podrían estar asociados a compromiso con factores ambientales y socioeconómicos. Se recomienda brindar apoyo interdisciplinario a las comunidades y trabajar en el diagnóstico a temprana edad con el fin de evitar discapacidad para desempeñarse en la sociedad y mitigar el impacto sobre las familias afectadas. Rev.cienc.biomed. 2015;6(2):251-258
Ependimoma mixopapilar osteolítico gigante del sacro: una forma agresiva de un tumor benigno
Authors: Tuñón Pitalúa Martha Cecilia , Ruiz Cáez Karina María , Niño Hernández Lucía Mercedes , Piña Cabrales Sandra , Alcalá Cerra Gabriel , Remolina López Anderson Julián
Published: January 2021

Introducción: el ependimoma mixopapilar (EM) es un tumor glial ependimario que afecta predominantemente a los adultos jóvenes, se origina en el filum terminale, la cauda equina y el cono medular.Caso clínico: se presenta el caso de una paciente en quien durante el estudio de un dolor radicular se logra detectar ependimoma mixopapilar gigante, el cual comprometía gran parte del hueso sacro, mostrando un comportamiento localmente agresivo con intensa osteólisis.Conclusión: se discutieron las posibles teorías que explican la presencia de estos tumores a nivel sacro, en especial la presencia de remanentes embrionarios de tejido ependimario en los niveles más caudales del canal vertebral y los posibles mecanismos que explican el comportamiento agresivo de estos tumores histológicamente benignos. Rev.cienc.biomed. 2015; 6(2):348-353
Ureterocele izquierdo con litiasis gigante en el adulto
Authors: Aljure Reales Vicente , Sepúlveda Fonseca Jefersson , Salamanca Jiménez David , Jaime Martínez Natalia , Prieto Vaca Paula
Published: January 2021

Introducción: el ureterocele es una dilatación quística del uréter submucoso distal, con prolapso dentro de la luz de la vejiga debido a un defecto muscular intrínseco en la pared ureteral. El objetivo del presente trabajo es describir un caso de ureterocele izquierdo ortotópico y la  presencia de un cálculo hiperdenso en la unión ureterovesical del lado derecho.Caso clínico: paciente masculino de 48 años de edad con cuadro clínico de un mes de evolución, consistente en dolor lumbar de moderada intensidad, irradiado a flanco y testículo derecho, refiere disuria y polaquiuria. Se realizó urotomografía axial, la cual reportó un cálculo  hiperdenso de aproximadamente 2 cm de diámetro en la unión ureterovesical del lado derecho, en el lado izquierdo se apreció ureterocele simple u ortotópico con apariencia de “cabeza de cobra”. Se optó por manejo quirúrgico como tratamiento definitivo, practicándose resección transuretral de ureterocele izquierdo y fragmentación con LithoClast del gran cálculo en el uréter derecho. Posteriormente se insertó catéter endoureteral doble jota.Conclusión: el ureterocele del adulto suele asociarse a sistemas ureterales únicos, completamente intravesicales u ortotópicos, el 18 % son bilaterales, porcentaje que esun poco mayor al 10%.Rev.cienc.biomed. 2015;6(2):360-363