bluuebunny/crossref_metadata_2025 huggingface dataset:
The RUNX/CBFβ Complex in Breast Cancer: A Conundrum of Context
Authors: Khan Adiba , Campbell Kirsteen , Cameron Ewan , Blyth Karen
Published: February 2023

Dissecting and identifying the major actors and pathways in the genesis, progression and aggressive advancement of breast cancer is challenging, in part because neoplasms arising in this tissue represent distinct diseases and in part because the tumors themselves evolve. This review attempts to illustrate the complexity of this mutational landscape as it pertains to the RUNX genes and their transcription co-factor CBFβ. Large-scale genomic studies that characterize genetic alterations across a disease subtype are a useful starting point and as such have identified recurring alterations in CBFB and in the RUNX genes (particularly RUNX1). Intriguingly, the functional output of these mutations is often context dependent with regards to the estrogen receptor (ER) status of the breast cancer. Therefore, such studies need to be integrated with an in-depth understanding of both the normal and corrupted function in mammary cells to begin to tease out how loss or gain of function can alter the cell phenotype and contribute to disease progression. We review how alterations to RUNX/CBFβ function contextually ascribe to breast cancer subtypes and discuss how the in vitro analyses and mouse model systems have contributed to our current understanding of these proteins in the pathogenesis of this complex set of diseases.
Emerging Mechanisms of Skeletal Muscle Homeostasis and Cachexia: The SUMO Perspective
Authors: Khan Bushra , Gand Luis Vincens , Amrute-Nayak Mamta , Nayak Arnab
Published: February 2023

Mobility is an intrinsic feature of the animal kingdom that stimulates evolutionary processes and determines the biological success of animals. Skeletal muscle is the primary driver of voluntary movements. Besides, skeletal muscles have an immense impact on regulating glucose, amino acid, and lipid homeostasis. Muscle atrophy/wasting conditions are accompanied by a drastic effect on muscle function and disrupt steady-state muscle physiology. Cachexia is a complex multifactorial muscle wasting syndrome characterized by extreme loss of skeletal muscle mass, resulting in a dramatic decrease in life quality and reported mortality in more than 30% of patients with advanced cancers. The lack of directed treatments to prevent or relieve muscle loss indicates our inadequate knowledge of molecular mechanisms involved in muscle cell organization and the molecular etiology of cancer-induced cachexia (CIC). This review highlights the latest knowledge of regulatory mechanisms involved in maintaining muscle function and their deregulation in wasting syndromes, particularly in cachexia. Recently, protein posttranslational modification by the small ubiquitin-like modifier (SUMO) has emerged as a key regulatory mechanism of protein function with implications for different aspects of cell physiology and diseases. We also review an atypical association of SUMO-mediated pathways in this context and deliberate on potential treatment strategies to alleviate muscle atrophy.
Tailoring Magnetic Properties and Magnetoimpedance Response in Nanocrystalline (Fe3Ni)81Nb7B12 Ribbons for Sensor Applications
Authors: González-Alonso David , Gonzalez-Legarreta Lorena , Marcin Jozef , Švec Peter , Škorvánek Ivan
Published: February 2023

Today, there is an increasing demand for progress in the magnetoimpedance (MI) response of cost-effective soft-magnetic materials for use in high-performance sensing devices. In view of this, we investigate here the field-annealing effects on soft-magnetic properties, magnetoimpedance response, and field sensitivity in the nanocrystalline (Fe3Ni)81Nb7B12 alloy ribbons. We observe that within the low-frequency regime, between 2 and 5 MHz, the zero-field-annealed (ZFA) ribbons exhibit the highest magnetoimpedance values. By magneto-optical Kerr effect measurements, we show that this result stems from the formation of irregular transversally patched magnetic domains after annealing, which in turn explains the induced transverse anisotropy necessary to increase the GMI response. In addition, we discuss this increment in terms of skin effect. Moreover, we report that the highest sensitivity of ca. 189%/(kA/m)—15%/Oe—is achieved for the field-annealed samples whose magnetic field was applied transverse to the ribbon axis. These findings are of practical importance to develop and refine highly sensitive magnetic sensors.
Special Issue: Tribological Coatings—Properties, Mechanisms, and Applications in Surface Engineering
Authors: Jakovljević Suzana , Landek Darko
Published: February 2023

Tribological coatings are found on machine elements (e [...]
Experimental Study on the Bending Resistance of Hollow Slab Beams Strengthened with Prestressed Steel Strand Polyurethane Cement Composite
Authors: Li Jin , Cui Yongshu , Xiong Dalu , Lu Zhongmei , Dong Xu , Zhang Hongguang , Cui Fengkun , Zhou Tiancheng
Published: February 2023

In order to explore the toughening performance and failure mechanism of hollow slab beams strengthened with prestressed steel strand polyurethane cement composite, three test beams (L1–L3) were strengthened and one test beam (L0) was used as a comparison. The influence of different tensile stresses of steel strand and fiber additions on the flexural bearing capacity of the hollow slab beams, was studied. The cracking characteristics, load deflection relationship, ductility and strain of each test beam were compared and analyzed. The test results showed that the toughened material was well bonded to the hollow slab beam and the steel strand, which effectively inhibited the development of cracks in the test beams. The flexural bearing capacity of the strengthened test beams was significantly improved. The use of prestressed steel strand polyurethane cement composite material effectively improved the flexural bearing capacity of the test beams, and this reinforcement process can be further extended to engineering applications.
The Fabrication of Gold–Silver Bimetallic Colloids by Microplasma: A Worthwhile Strategy for Counteracting the Surface Activity of Avian Influenza Virus
Authors: Zubair Muhammad , Rafique Muhammad Shahid , Khalid Afshan , Yaqub Tahir , Shahid Muhammad Furqan , Alomar Suliman Yousef , Shar Muhammad Ali
Published: February 2023

In the present project, fructose-stabilized gold, silver and gold–silver bimetallic colloids have been synthesized by the electrochemical reduction of HAuCl4·3H2O (Au precursor) and AgNO3 (Ag precursor), employing the atmospheric pressure microplasma technique. X-Ray Diffraction patterns of gold–silver bimetallic particles exhibit (111), (200) and (220) planes identical to gold and silver NPs depicting FCC structures. The decrease in the peak intensities of Au–Ag (111) and Au–Ag (200) as compared to those of Au (111) and (200) is due to the formation of Au–Ag alloys. The FE-SEM image of gold–silver bimetallic NPs has revealed an adequate change in morphology as compared to the morphology of gold NPs and silver NPs. The majority of the gold–silver bimetallic NPs are spherical and are uniformly dispersed. The EDS spectra of (Au–Ag) confirm the presence of metallic gold and silver. The appearance of a single Surface Plasmon Resonance (SPR) peak in the UV–VIS absorption spectra of gold–silver colloids and its position in between the SPR peaks of the UV–VIS absorption spectra of gold and silver colloids justify the formation of gold–silver bimetallic alloy particles. In DLS measurements, the size distribution of gold–silver bimetallic colloids carries a narrow range 55 to 117 nm as compared to the size distribution of gold and silver colloids. The compatibility of the sizes of these colloids and the influenza virus belonging to the Orthomyxoviruses family (size range 80–300 nm with different morphologies) are assumed to stand responsible for an effective bio-conjunction with Influenza viruses. Au–Ag bimetallic nanostructures have synergistically improved their antiviral activity against H9N2 influenza virus as compared to monometallic AuNPs and AgNPs. Thus, the Au–Ag nanostructured alliance has been proven to be more effective and is capable of manifesting high antiviral efficacy.
Microstructural, Mechanical, and Corrosion Properties of AZXX Magnesium Alloy: A Review of Processing Methods
Authors: B. Shalu Pargavi , Dhanaji Todkar Utkarsh , Dassani Sejal , Somasundaram M. , Muthuchamy A. , Raja Annamalai A.
Published: February 2023

Magnesium (Mg) and its alloys are considered an ideal material for aerospace, medical, energy, and automotive purposes, because of their low density and high specific strength. Researchers are interested in AZ alloys because of their superior flow characteristics. This review makes an effort to summarise the numerous processing methods that have been adapted for use with AZXX alloy. One of the main obstacles to Mg alloys being used in their intended context is the difficulty of processing Mg and its alloys. Curiously, the homogenization process is often used in tandem with extrusion and rolling. It also gives an insight into the microstructure, mechanical (hardness, tensile, impact, fatigue, and creep), and electrochemical corrosion properties of AZXX alloys. The improvement of AZXX alloy can be attributed to the grain boundary strengthening and the second phase strengthening mechanisms. The effects of Al content and phases on properties are extensively discussed. This article summarises what has recently happened with AZXX wrought Mg alloy and offers some predictions for its future.
Characterizing and Quantifying Water Content in 14 Species of Bryophytes Present in Azorean Native Vegetation
Authors: Coelho Márcia C. M. , Gabriel Rosalina , Ah-Peng Claudine
Published: February 2023

Bryophytes are an important component of plant diversity, may be found from sea level to mountaintops, and are particularly conspicuous on the Azores islands. These plants rely on environmental water, which acquires intercepting rain and dew (liquid water) and uses fog (water vapor), and transports both externally, by capillary forces, and internally, in different cells (specialized or not). This study characterizes and quantifies the ability of six liverworts and eight mosses to retain water, through different pathways, and to lose water by evaporation. Twelve replicates of each species were collected in Azorean native vegetation during the summer of 2016. The absolute water content (AWC) was obtained through measurements of specimens saturated, without free water, and completely dry. Most of the 14-target species showed an ectohydric behavior pattern retaining more than 60% of water through gametophyte surface. The AWC value ranged from 646% in Polytrichum commune to 5584% in Sphagnum subnitens. The water loss by direct evaporation showed, for most of species, an exponential decay curve along time. Understanding how much native bryophytes, acquire, store, and release water into the system contributes not only to the knowledge of native vegetation resilience but also to potential impacts on the availability and quality of water—a major ecosystem service performed by bryophytes.
Is the Level of Contrast Enhancement on Contrast-Enhanced Mammography (CEM) Associated with the Presence and Biological Aggressiveness of Breast Cancer?
Authors: Marzogi Alaa , Baltzer Pascal A. T. , Kapetas Panagiotis , Milos Ruxandra I. , Bernathova Maria , Helbich Thomas H. , Clauser Paola
Published: February 2023

There is limited information about whether the level of enhancement on contrast-enhanced mammography (CEM) can be used to predict malignancy. The purpose of this study was to correlate the level of enhancement with the presence of malignancy and breast cancer (BC) aggressiveness on CEM. This IRB-approved, cross-sectional, retrospective study included consecutive patients examined with CEM for unclear or suspicious findings on mammography or ultrasound. Excluded were examinations performed after biopsy or during neoadjuvant treatment for BC. Three breast radiologists who were blinded to patient data evaluated the images. The enhancement intensity was rated from 0 (no enhancement) to 3 (distinct enhancement). ROC analysis was performed. Sensitivity and negative likelihood ratio (LR-) were calculated after dichotomizing enhancement intensity as negative (0) versus positive (1–3). A total of 156 lesions (93 malignant, 63 benign) in 145 patients (mean age 59 ± 11.6 years) were included. The mean ROC curve was 0.827. Mean sensitivity was 95.4%. Mean LR- was 0.12%. Invasive cancer presented predominantly (61.8%) with distinct enhancement. A lack of enhancement was mainly observed for ductal carcinoma in situ. Stronger enhancement intensity was positively correlated with cancer aggressiveness, but the absence of enhancement should not be used to downgrade suspicious calcifications.
2D Camera-Based Air-Writing Recognition Using Hand Pose Estimation and Hybrid Deep Learning Model
Authors: Watanabe Taiki , Maniruzzaman Md. , Hasan Md. Al Mehedi , Lee Hyoun-Sup , Jang Si-Woong , Shin Jungpil
Published: February 2023

Air-writing is a modern human–computer interaction technology that allows participants to write words or letters with finger or hand movements in free space in a simple and intuitive manner. Air-writing recognition is a particular case of gesture recognition in which gestures can be matched to write characters and digits in the air. Air-written characters show extensive variations depending on the various writing styles of participants and their speed of articulation, which presents quite a difficult task for effective character recognition. In order to solve these difficulties, this current work proposes an air-writing system using a web camera. The proposed system consists of two parts: alphabetic recognition and digit recognition. In order to assess our proposed system, two character datasets were used: an alphabetic dataset and a numeric dataset. We collected samples from 17 participants and asked each participant to write alphabetic characters (A to Z) and numeric digits (0 to 9) about 5–10 times. At the same time, we recorded the position of the fingertips using MediaPipe. As a result, we collected 3166 samples for the alphabetic dataset and 1212 samples for the digit dataset. First, we preprocessed the dataset and then created two datasets: image data and padding sequential data. The image data were fed into the convolution neural networks (CNN) model, whereas the sequential data were fed into bidirectional long short-term memory (BiLSTM). After that, we combined these two models and trained again with 5-fold cross-validation in order to increase the character recognition accuracy. In this work, this combined model is referred to as a hybrid deep learning model. Finally, the experimental results showed that our proposed system achieved an alphabet recognition accuracy of 99.3% and a digit recognition accuracy of 99.5%. We also validated our proposed system using another publicly available 6DMG dataset. Our proposed system provided better recognition accuracy compared to the existing system.
Comparative Analysis of Traffic-Reduction Techniques for Seamless CAN-Based In-Vehicle Network Systems
Authors: Hoang Duc N. M. , Park Sang Yoon , Rhee Jong Myung
Published: February 2023

Due to the benefits of better bandwidth and reliability, the automotive industry is moving towards Ethernet-based in-vehicle network (IVN) systems as the number of onboard electronic control units has increased. Considering that before long the well-known controller area network (CAN) will still be considered a standard protocol, our earlier work introduced a high-availability seamless redundancy (HSR)-based Ethernet network architecture that provides IVNs with fault tolerance, called seamless CAN. However, HSR is known for its redundant traffic generated for fault tolerance, which is a disadvantage in bandwidth-limited IVN systems. Therefore, in this paper, we propose a traffic-effective architecture for seamless CAN-based networks. We compared the proficiency of different traffic-reduction approaches as they were applied to our proposed architecture. Extensive simulation results showed that our proposed solution could reduce up to 54% of the total network traffic compared to a conventional architecture while still being able to guarantee a high level of fault tolerance.
LiDAR SLAM with a Wheel Encoder in a Featureless Tunnel Environment
Authors: Filip Iulian , Pyo Juhyun , Lee Meungsuk , Joe Hangil
Published: February 2023

Simultaneous localization and mapping (SLAM) represents a crucial algorithm in the autonomous navigation of ground vehicles. Several studies were conducted to improve the SLAM algorithm using various sensors and robot platforms. However, only a few works have focused on applications inside low-illuminated featureless tunnel environments. In this work, we present an improved SLAM algorithm using wheel encoder data from an autonomous ground vehicle (AGV) to obtain robust performance in a featureless tunnel environment. The improved SLAM system uses FAST-LIO2 LiDAR SLAM as the baseline algorithm, and the additional wheel encoder sensor data are integrated into the baseline SLAM structure using the extended Kalman filter (EKF) algorithm. The EKF algorithm is used after the LiDAR odometry estimation and before the mapping process of FAST-LIO2. The prediction step uses the wheel encoder and inertial measurement unit (IMU) data, while the correction step uses the FAST-LIO2 LiDAR state estimation. We used an AGV to conduct experiments in flat and inclined terrain sections in a tunnel environment. The results showed that the mapping and the localization process in the SLAM algorithm was greatly improved in a featureless tunnel environment considering both inclined and flat terrains.
Application of A* Algorithm Based on Extended Neighborhood Priority Search in Multi-Scenario Maps
Authors: You Zhiyu , Shen Keyu , Huang Tao , Liu Yongxin , Zhang Xiaofeng
Published: February 2023

The robustness of the traditional A* algorithm of path planning is poor due to its excessive number of traversal nodes, slow search speed, and large turning angle. Aiming to solve the above problems, a multi-scenario adaptive A* algorithm based on extended neighborhood priority search is proposed. Firstly, this algorithm designs the heuristic function that can adapt to various scene changes by quantifying the scene map information, and the search weight is adjusted adaptively to enhance the robustness and adaptability of the algorithm. Secondly, the search strategy based on extended neighborhood priority is adopted to improve the orientation of the algorithm, and the redundant node removal strategy is used to smooth the path to reduce the number of traversed nodes and the turning angle. Finally, simulation tests are conducted in several representative map environments. The test results show that the proposed algorithm is superior to the traditional A* algorithm due to its stronger robustness and significantly improved performance metrics, with an 84.95% reduction in the number of traversal nodes, an 83.84% reduction in the number of path nodes, a 62.28% reduction in turning points on the path, a 77.38% reduction in the total turning angle, and a 58.47% reduction in the search time.
Effects of Different Factors on Single Event Effects Introduced by Heavy Ions in SiGe Heterojunction Bipolar Transistor: A TCAD Simulation
Authors: Zhang Zheng , Guo Gang , Li Futang , Sun Haohan , Chen Qiming , Zhao Shuyong , Liu Jiancheng , Ouyang Xiaoping
Published: February 2023

In this paper, the effects of different factors, including the heavy ions striking location, incident angle, linear energy transfer (LET) value, projected range, ambient temperature and bias state, on the single event transient introduced by heavy ions irradiation in the SiGe heterojunction bipolar transistor (HBT) were investigated by the TCAD simulation. The results show that the current transient peak value, collected charge and carrier type of each terminal are changed by the striking location, incident angle and bias state. The current transient peak value and collected charge increase with the LET value, while they decrease with the ambient temperature. When heavy ions vertically irradiate the collector and substrate, the current transient peak value and collected charge increase with the projected range; therefore, the species of heavy ions should be considered in studying the single event effects of the SiGe HBT induced by heavy ions irradiation. The microphysical mechanism of these factors influencing the single event effects of the SiGe HBT is discussed in this work.
A Comparison of Thermal Insulation with Interstitial Condensation in Different Climate Contexts in Existing Buildings in Europe
Authors: Tronchin Lamberto , Fabbri Kristian , Tommasino Maria Cristina
Published: February 2023

The work presented here investigates the risk of interstitial condensation between the existing masonry and the insulation using several materials and evaluates the water content inside the insulation (WCI) through various simulations in dynamic mode onto existing buildings located in different countries in Europe. The insulation materials considered are specifically: natural fibre materials, mineral fibre materials, and artificial materials. The scenarios were chosen considering different climate zones, according to the Köppen climate classification, and the analysed buildings were taken from the TABULA database in the years of construction from 1945 to 1969. The building typologies are single-family houses, where in each building system the insulation was placed towards the warm side with a fixed thickness of 5 cm. The simulations concerned: (a) the application scenario, (b) the type of stratigraphy chosen, and (c) the exposure of the existing building system. The outputs generated by the simulations provided the data to determine in which type of building, depending on the insulating materials, interstitial condensation is formed or not. It is shown that only for the climate zones of the cities of Oslo and Brussels, associated with their building typologies, for the insulating materials: mineral and natural, is there the formation of interstitial condensation
Does Proximity to a Power Plant Affect Housing Property Values of a City in South Korea? An Empirical Investigation
Authors: Kim Ju-Hee , Kim Young-Kuk , Yoo Seung-Hoon
Published: February 2023

The South Korean government plans to switch from a centralized power generation method to a distributed one. However, due to opposition from local residents, construction of distributed power plants is frequently delayed or suspended. This study attempts to investigate whether proximity to a power plant negatively affects housing property values, using the hedonic pricing technique and quantitatively analyzing the level of impact. To this end, 2291 apartment sales data from a specific city in the South Korean Seoul Metropolitan area with a power plant were used. As a result of the analysis, it was found that proximity to a power plant had a negative effect on apartment prices, which was statistically significant at the significance level of 5%. The difference in apartment prices per 1 km direct distance from the power plant to the apartment was derived as KRW 8 million (USD 7.1 thousand). This value is about 0.7% of the average price of apartments in the area (KRW 1102 million = USD 0.98 thousand). The results of this study can be used as a useful reference when the government determines the size of subsidies for local residents near power plants.
Reinforcement of Timber Dowel-Type Connections Using Self-Tapping Screws and the Influence of Thread Configurations
Authors: Zhang Cong , Huang Hao-Yu , Li Xiong-Yan , Xue Su-Duo , Chang Wen-Shao , Sun Guo-Jun
Published: February 2023

The application of self-tapping screws as reinforcement on glulam connections has been proven effective. However, the implication of different thread configurations on the effectiveness of reinforcement remains unknown. This paper conducted experiments using screws with various thread configurations in embedment-strength tests and tensile connection tests. Results show that self-tapping screws with one third of thread achieved similar improvement in the embedment strength and mechanical properties of connections as fully threaded screws. This implies that properly reducing the thread length on self-tapping screws ensures easier screw installation than using fully threaded screws. The influence of screw-to-dowel distance was also investigated and two distances (0.5 d and 1 d) were adopted, with ‘d’ being the diameter of the dowel. The difference in embedment strength due to different screw-to-dowel distances was insignificant. The group with screws placed in contact (0.5 d) with the dowel achieved 5% higher embedment strength than the group with screws placed at a 1 d distance. The connection tests showed good agreement with the embedment-strength tests. This confirms that self-tapping screws with reduced thread can enhance the load-carrying capacity and ductility of connections to a level similar to connections reinforced by fully threaded screws.
Transcriptome Identification of R2R3-MYB Gene Family Members in Pinus massoniana and PmMYB4 Response to Drought Stress
Authors: Lou Xuan , Yao Sheng , Chen Peizhen , Wang Dengbao , Agassin Romaric Hippolyte , Hou Yanqing , Zhang Chi , Ji Kongshu
Published: February 2023

One of the largest families of transcription factors in plants, the MYB transcription factors family (Myeloblastosis, MYB TF), plays a vital role in regulating plant biochemical and physiological processes. The role of MYB TF in coping with stresses, such as drought, salt and cold, has been reported. Unfortunately, a comprehensive identification of R2R3-MYB TF in Masson pine (Pinus massoniana) has not been achieved. In this study, a total of 49 sequences were identified as R2R3-MYB TF. The structure, function and phylogenetic relationships of the conserved structural domains of Masson pine R2R3-MYB TF and Populus trichocarpa Torr. & A.Gray ex Hook. TFs were compared using bioinformatics tools. The results showed that Masson pine R2R3-MYB TF was divided into 24 groups, mainly located in the nucleus, and mostly lacking signal peptides and transmembrane structural domains with multiple phosphorylation sites. The drought stress-responsive R2R3-MYB gene, PmMYB4, was selected from the drought stress transcriptome based on analysis of the expression pattern and tissue specificity of PmMYB4 gene under abiotic stress using qPCR. The results showed that PmMYB4 can be involved in drought stress treatment through ABA signaling, as well as in multiple stress responses such as salt stress, and there were significant differences in the expression of PmMYB4 in the eight tissues. These results provide a reference scheme for the functional identification of R2R3-MYB transcription factors, which may be involved in plant responses to multiple stresses such as drought, and enrich our understanding of the functions of R2R3-MYB transcription factors in plants.
Milk from Halari Donkey Breed: Nutritional Analysis, Vitamins, Minerals, and Amino Acids Profiling
Authors: Garhwal Renu , Bhardwaj Anuradha , Sangwan Karnam , Mehra Rahul , Pal Yash , Nayan Varij , Iquebal Mir Asif , Jaiswal Sarika , Kumar Harish
Published: February 2023

This current research set out to characterize Halari donkey milk by investigating its nutritional constituents, including its proximate analysis, water activity, titratable acidity, energy, and microbiological analysis. A comprehensive profiling of vitamins, minerals, and amino acids was also carried out. It was found that the composition of Halari donkey milk was consistent with previously published donkey milk literature and was comparable to that of human milk. Halari donkey milk has low 0.86 ± 0.04% fat content, 2.03 ± 0.03% protein content, 0.51 ± 0.05% ash content, and high 5.75 ± 0.15% lactose content making it sweet and palatable. The energy content of Halari donkey milk was 40.39 ± 0.31 kcal/100 g, and the water activity ranged from 0.973 to 0.975. Titratable acidity was 0.03 ± 0.01%. Halari donkey milk can be considered acceptable and microbiologically safe, having low total plate count and yeast and mould counts. Mineral testing revealed that Halari donkey milk included significant amounts of magnesium, sodium, calcium, potassium, phosphorus, and zinc. The concentration of different vitamins and amino acids such as isoleucine and valine also contribute to the nutritional value of Halari donkey milk.
Strategies for Producing Low FODMAPs Foodstuffs: Challenges and Perspectives
Authors: Galgano Fernanda , Mele Maria Cristina , Tolve Roberta , Condelli Nicola , Di Cairano Maria , Ianiro Gianluca , D’Antuono Isabella , Favati Fabio
Published: February 2023

In recent years, there has been a growing interest in a diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs) as a promising therapeutic approach to reduce the symptoms associated with irritable bowel syndrome (IBS). Hence, the development of low FODMAPs products is an important challenge for the food industry, and among the various foodstuffs associated with the intake of FODMAPs, cereal-based products represent an issue. In fact, even if their content in FODMAPs is limited, their large use in diet can be an important factor in developing IBS symptoms. Several useful approaches have been developed to reduce the FODMAPs content in processed food products. Accurate ingredient selection, the use of enzymes or selected yeasts, and the use of fermentation steps carried out by specific lactic bacteria associated with the use of sourdough represent the technical approaches that have been investigated, alone or in combination, to reduce the FODMAPs content in cereal-based products. This review aims to give an overview of the technological and biotechnological strategies applicable to the formulation of low-FODMAPs products, specifically formulated for consumers affected by IBS. In particular, bread has been the foodstuff mainly investigated throughout the years, but information on other raw or processed products has also been reported. Furthermore, taking into account the required holistic approach for IBS symptoms management, in this review, the use of bioactive compounds that have a positive impact on reducing IBS symptoms as added ingredients in low-FODMAPs products is also discussed.
Screening of Bifidobacteria with Probiotic Potential from Healthy Infant Feces by Using 2′-Fucosyllactose
Authors: Zhang Gongsheng , Sun Hui , Xu Zihe , Tan Ze , Xiao Lihong , He Mingxue , Shang Jiaqi , Tsapieva Anna N. , Zhang Lili
Published: February 2023

Using 2′-fucosyllactose (2′-FL) as the sole carbon source can be an efficient way to screen bifidobacteria with superior probiotic capabilities since 2′-FL is a key element in promoting the growth of intestinal bifidobacteria in newborns. This approach was used in this work to screen eight bifidobacteria strains, including one strain of Bifidobacterium longum subsp. infantis BI_Y46 and seven strains of Bifidobacterium bifidum (BB_Y10, BB_Y30, BB_Y39, BB_S40, BB_H4, BB_H5 and BB_H22). Studies on their probiotic properties showed that BI_Y46 had a unique morphology with pilus-like structure, a high resistance to bile salt stimulation and a potent inhibitory action on Escherichia coli ATCC 25922. Similarly, BB_H5 and BB_H22 produced more extracellular polysaccharides and had a higher protein content than other strains. In contrast, BB_Y22 displayed considerable auto-aggregation activity and a high resistance to bile salt stimulation. Interestingly, BB_Y39 with weak self-aggregation ability and acid resistance had very excellent bile salt tolerance, extracellular polysaccharides (EPS) production and bacteriostatic ability. In conclusion, 2′-FL was used as sole carbon source to identify eight bifidobacteria with excellent probiotic properties.
The rs3825807 Polymorphism of ADAMTS7 as a Potential Genetic Marker for Myocardial Infarction in Slovenian Subjects with Type 2 Diabetes Mellitus
Authors: Petrovič David , Nussdorfer Petra , Petrovič Danijel
Published: February 2023

Background: A disintegrin and metalloprotease with thrombospondin motif 7 (ADAMTS-7) was reported to play a role in the migration of vascular smooth muscle cells and neointimal formation. The object of the study was to investigate the association between the rs3825807 polymorphism of ADAMTS7 and myocardial infarction among patients with type 2 diabetes mellitus in a Slovenian cohort. Methods: 1590 Slovenian patients with type 2 diabetes mellitus were enrolled in this retrospective cross-sectional case–control study. In total, 463 had a history of recent myocardial infarction, and 1127 of the subjects in the control group had no clinical signs of coronary artery disease. Genetic analysis of an rs3825807 polymorphism of ADAMTS7 was performed with logistic regression. Results: Patients with the AA genotype had a higher prevalence of myocardial infarction than those in the control group in recessive [odds ratio (OR) 1.647; confidence interval (CI) 1.120–2.407; p = 0.011] and co-dominant (OR 2.153; CI 1.215–3.968; p = 0.011) genetic models. Conclusion: We found a statistically significant association between rs3825807 and myocardial infarction in a cohort of Slovenian patients with type 2 diabetes mellitus. We report that the AA genotype might be a genetic risk factor for myocardial infarction.
High-Definition 3D Exoscope-Assisted Barbed Pharyngoplasty for OSAS and Snoring: Better Than Live
Authors: Casale Manuele , Moffa Antonio , Pierri Michelangelo , Baptista Peter , Giorgi Lucrezia
Published: February 2023

Recently, a high-definition 3D exoscope (VITOM), a new magnification system that provides a 3D image of the surgical field, has been introduced. This study aims to describe the first use of VITOM 3D technology in Barbed Pharyngoplasty (BP) for Obstructive Sleep Apnea (OSA). VITOM 3D technology is used to support visualization during BP in a male patient affected by severe OSA with a circular palatal collapse pattern at drug-induced sleep endoscopy. During the surgical procedure, this approach markedly improves the visualization of the surgical field through anatomic details of the oral cavity, facilitating surgical dissection and enhancing the teaching environment. It allows for a better involvement and more interactions during the surgery, as scrubbed and assistant nurses can see the surgical field and anticipate the surgeon’s choice of instrument. VITOM 3D technology, by combining a telescope with a standard endoscope, has been successfully used in various surgical disciplines and could be very useful, especially in teaching hospitals. VITOM 3D can guarantee “a real immersive” surgical experience for all participants in the operating room. Economic and efficacy studies would be conducted to support the use of a VITOM-3D exoscope in common clinical practice.
Adaptation, Validity, and Reliability of the Patient Health Questionnaire (PHQ-9) in the Kurdistan Region of Iraq
Authors: Policastro Francesca , Rossi Alessandra , Sulaiman Hushyar Musa , Taib Nezar Ismet
Published: February 2023

Aim: The Patient Health Questionnaire (PHQ-9) is widely used for detecting and screening depression in Iraq. However, no psychometric assessment has been performed on any Iraqi version. This study aims at studying the reliability and validity of the Iraqi Kurdish version of the PHQ-9 as tool for identifying depression. Methods: A cross-sectional study design was used; data were collected from 872 participants (49.3% female and 51.7% male) at Primary Health Care Centers (PHCCs) in the host community as well as from Internal Displaced Persons (IDPs) and refugee camps. Sociodemographic information was obtained; PHQ-9 for the diagnosis and screening of depression and Self Reporting Questionnaire 20 items (SRQ-20) for the screening of common mental illnesses were administered. Validity and reliability analyses were performed. Results: In total, 19% of the participants had a PHQ-9 total score equal to or higher than the clinical cut-off of 10 for diagnosing depressive disorder. The internal consistency of the PHQ-9 was good (Cronbach’s alpha coefficient was 0.89). Good concurrent validity for PHQ-9 compared with SRQ-20 (71%, p < 0.001) was found. Conclusions: The PHQ-9 demonstrates good psychometric properties and proves to be a good tool for detecting and screening depression.
Compliance with Ministry of Health Regulations among Israeli Nurses during the COVID-19 Pandemic: The Mediating Role of Risk Perception
Authors: Bord Shiran , Shahrabani Shosh , Baruch Hagar , Admi Hanna
Published: February 2023

The COVID-19 pandemic has created a sustained state of emergency, causing uncertainty and risk taking. Israeli nurses were required to follow new regulations and safety measures issued by the Israeli Ministry of Health (MOH). This study aimed to examine nurses’ compliance with MOH regulations and its association with their risk and threat perceptions and their positive and negative emotions. A cross-sectional online survey was conducted among 346 Israeli nurses. The study model was examined with path analysis. Most nurses reported complying with MOH regulations either fully (49%) or very often (30%). Negative emotions were positively associated with perceptions of both threat and risk, yet only risk perception was positively associated with nurses’ compliance. A significant mediated relationship was found between negative emotions and nurses’ compliance, with the possible mediator being risk perception. Hence, higher negative emotions were associated with a greater risk perception, which was associated with higher compliance. Health systems leaders must strategize to deal with the wave-like character of the pandemic. Solutions to nursing teams’ negative emotions must be provided to keep the balance between feelings of complacency and a situation of high-level, intense negative feelings, which might lead to abstention, burnout, or emotional injury.
Developmental Features, Influencing Factors, and Formation Mechanism of Underground Mining–Induced Ground Fissure Disasters in China: A Review
Authors: Li Yu , Liu Hui , Su Lijuan , Chen Sidi , Zhu Xiaojun , Zhang Pengfei
Published: February 2023

Mining–induced ground fissures are one of the major geological disasters affecting coal mines. In recent years, many effective monitoring methods have been developed to explore the developmental characteristics and nature of mining–induced ground fissures for being treated scientifically. This paper is mainly on the development law and mechanism of mining ground fissure research results which have been comprehensively combed, highlighting the development trend, including the formation condition, development features, influencing factors, and mechanical mechanism of mining–induced ground fissures. Outstanding issues are discussed and future research hot spots and trends are pointed out. The major conclusions include: (1) under the shallow coal mining condition, because the rock layer fault zone directly reaches the surface, the ground fissure usually develops seriously; (2) mining–induced ground fissures are generally divided into four types: tensile fissures, compression fissures, collapsed fissures, and sliding fissures; (3) mining–induced ground fissures are affected by the coupling effect of underground mining and surface topography. The main factors are geological mining conditions, surface deformation, and surface topography, including rock and soil structure, rock and soil mechanical properties, surface horizontal deformation, surface slope, and so on; and (4) to ensure the safety of underground mining, temporary ground fissures formed during the process of coal mining must be treated when ground fissures and rock ground fissures are connected. The results of this article make up for the deficiencies of the relevant research, provide the basis and direction for future research, and have universal applicability and scientific guiding significance.
Thwarting Instant Messaging Phishing Attacks: The Role of Self-Efficacy and the Mediating Effect of Attitude towards Online Sharing of Personal Information
Authors: Lee Yi Yong , Gan Chin Lay , Liew Tze Wei
Published: February 2023

Context: The cause of cybercrime phishing threats in Malaysia is a lack of knowledge and awareness of phishing. Objective: The effects of self-efficacy (the ability to gain anti-phishing knowledge) and protection motivation (attitude toward sharing personal information online) on the risk of instant messaging phishing attacks (phishing susceptibility) are investigated in this study. The protection motivation theory (PMT) was tested in the context of attitudes toward sharing personal information online with a view to improving interventions to reduce the risk of phishing victimisation. Methods: Data were collected using non-probability purposive sampling. An online survey of 328 Malaysian active instant messaging users was collected and analysed in SmartPLS version 4.0.8.6 using partial least squares structural equation modelling. Results: The results showed that a person’s cognitive factor (either high or low self-efficacy) affected their chance of being a victim of instant message phishing. A higher level of self-efficacy and a negative attitude towards sharing personal information online were significant predictors of phishing susceptibility. A negative attitude towards sharing personal information online mediated the relationship between high levels of self-efficacy and phishing susceptibility. A higher level of self-efficacy led to the formation of negative attitudes among internet users. Attitudes toward the sharing of personal information online are critical because they allow phishing attempts to exist and succeed. Conclusions: The findings give government agencies more information on how to organise anti-phishing campaigns and awareness programmes; awareness and education can improve one’s ability to acquire anti-phishing knowledge (self-efficacy).
Study on the Fingerprint and Atmospheric Activity of Volatile Organic Compounds from Typical Industrial Emissions
Authors: Gu Xin , Chen Kaitao , Cai Min , Yin Zhongyi , Liu Xingang , Li Xingru
Published: February 2023

China is prone to severe surface ozone pollution in summer, so it is very important to understand the source of volatile organic compounds (VOCs) to control ozone formation. In this work, the emission characteristics of 91 VOC components from the plastic products industry, packaging and printing industries, printing ink industry, furniture manufacturing and vehicle manufacturing industries were studied. The results show that there are significant differences between these sources, and for the plastic products industry, alkanes (48%) are the most abundant VOCs. The main emission species in the packaging and printing industry are OVOCs (36%) and alkanes (34%). The proportion of OVOCs in the printing ink (73%) and furniture manufacturing industries (49%) is dominated by VOC emissions; aromatic hydrocarbons (33%), alkanes (33%), and OVOCs (17%) are the main emission species in the vehicle manufacturing industry. At the same time, the ozone generation potential (OFP) and secondary organic aerosol formation potential (SOA) of anthropogenic VOC emissions were evaluated, and the top 10 contributors to OFP and SOA were identified. Toluene, o-xylene, and m-xylene had a significant tendency to form OFP or SOA. Then, a health risk assessment of VOC components was carried out. These data can supplement the existing VOC emission characteristics of anthropogenic emissions, thus enriching the research progress of VOC emission sources.
A Markov Chain Model for Mental Health Interventions
Authors: Claudio David , Moyce Sally , Albano Tyler , Ibe Ekeoma , Miller Nick , O’Leary Marshall
Published: February 2023

Poor mental health affects nearly one billion people worldwide and can end in suicide if not treated. Unfortunately, stigma and a lack of mental healthcare providers are barriers to receiving needed care. We developed a Markov chain model to determine whether decreasing stigma or increasing available resources improves mental health outcomes. We mapped potential steps in the mental health care continuum with two discrete outcomes: getting better or committing suicide. Using a Markov chain model, we calculated probabilities of each outcome based on projected increases in seeking help or availability of professional resources. Modeling for a 12% increase in awareness of mental health concerns yielded a 0.39% reduction in suicide. A 12% increase in access to professional help yielded a 0.47% reduction in suicide rate. Our results show that expanding access to professional services has a higher impact on reducing suicide rates than creating awareness. Any intervention towards awareness or access positively impacts reducing suicide rates. However, increased access results in a higher reduction in suicide rates. We have made progress in increasing awareness. Awareness campaigns help to increase recognition of mental health needs. However, focusing efforts on increasing access to care may have a higher impact on reducing suicide rates.
Using EMA and Physiological Data to Explore the Relationship between Day-to-Day Occupational Stress, Musculoskeletal Pain and Mental Health among University Staff: A Study Protocol
Authors: Weale Victoria , Love Jasmine , Clays Els , Oakman Jodi
Published: February 2023

Exposure to work-related stressors is associated with poor physical and mental health outcomes for workers. The role of chronic stressors on health outcomes has been explored, but less is known about the potential role of exposure to day-to-day stressors on health. This paper describes the protocol for a study that aims to collect and analyze day-to-day data on work-related stressors and health outcomes. Participants will be workers engaged in predominantly sedentary work at a university. Self-report data on work-related stressors, musculoskeletal pain, and mental health will be collected three times per day for 10 work days through ecological momentary assessment via online questionnaires. These data will be combined with physiological data collected continuously via a wristband throughout the working day. The feasibility and acceptability of the protocol will be assessed via semi-structured interviews with participants and adherence to the study protocol. These data will inform the feasibility of using the protocol in a larger study to investigate the relationship between exposure to work-related stressors and health outcomes.
Remote Sensing Application in Mountainous Environments: A Bibliographic Analysis
Authors: Jombo Simbarashe , Abd Elbasit Mohamed A. M. , Gumbo Anesu D. , Nethengwe Nthaduleni S.
Published: February 2023

Advancement in remote sensing platforms, sensors, and technology has significantly improved the assessment of hard-to-access areas, such as mountains. Despite these improvements, Africa lags in terms of research work published. This is of great concern as the continent needs more research to achieve sustainable development. Therefore, this study applied a bibliometric analysis of the annual production of publications on the application of remote sensing methods in mountainous environments. In total, 3849 original articles between 1973 and 2021 were used, and the results indicate a steady growth in publications from 2004 (n = 26) to 2021 (n = 504). Considering the source journals, Remote Sensing was the top-ranked, with 453 total publications. The University of the Chinese Academy of Sciences was the highest-ranking affiliation, with 217 articles, and China produced the highest number of publications (n = 217). Keywords used between 1973 and 1997, such as “Canada”, “alps”, and “GIS”, metamorphosed into “remote sensing” between 1998 and 2021. This metamorphosis indicates a change in the areas of interest and an increase in the application of remote sensing methods. Most studies were conducted in the Global North countries, and a few were published in low-impact journals within the African continent. This study can help researchers and scholars better understand the progress and intellectual structure of the field and future research directions in the application of remote sensing methods in mountainous environments.