bluuebunny/crossref_metadata_2025 huggingface dataset:
Modified Multiscale Renyi Distribution Entropy for Short-Term Heart Rate Variability Analysis
Authors: Shi Manhong , Shi Yinuo , Lin Yuxin , Qi Xue
Published: April 2023

Background: Multiscale sample entropy (MSE) is a prevalent complexity metric to characterize a time series and has been extensively applied to the physiological signal analysis. However, the application of MSE will not be satisfactory due to its inaccurate or mathematics constraints for a short-term time series as the scale factor increases. To overcome the shortcoming, a modified multiscale Renyi distribution entropy (MMRDis) was proposed in our present work
Methods: The MMRDis method uses a moving-averaging procedure to acquire a family of time series, each of which quantify the dynamic behaviors of the short-term time series over the multiple temporal scales. Then, MMRDis is constructed for the original and the coarse-grained time series.
Results: We showed the MMRDis method on simulated Gaussian white and 1/f noise time series, indicating that MMRDis had a superior computational stability and can avoid the occurrence of undefined measurement for the short-term time series. Besides, the short-term heart rate variability (HRV) signals extracted from healthy elderly, healthy young people and subjects with congestive heart failure and atrial fibrillation were used to evaluate the performance of MMRDis. The results showed that the complexity measurement values of MMRDis decreased with aging and disease and had the better distinction capability for the short-term HRV physiology/pathological signals than those of several recently proposed complexity metrics,
Conclusions: MMRDis was a promising measurement for screening cardiovascular condition within a short time.
Research on the mechanism of synergistic treatment of VOCs-O 3 by low temperature plasma catalysis technology
Authors: Zhang Lei , Zou Zhuorui , Lei Zhang , Jia Yang
Published: April 2023

In this research, xylene was utilized as a simulated gas, γ-Al2O3 pellets were selected as catalyst carriers, and FeOx, MnOx, CeOx, and CuOx were used as active components to analyze the synergistic treatment of VOCs-O3 by low-temperature plasma combined with supported catalysts. Different metal oxides and other factors influence the synergistic treatment of VOCs-O3. The results showed that the catalytic effect of Fe-Mn/γ-Al2O3 prepared by the equivalent volumes of consecutive impregnation method was better than that of Fe-Mn/γ-Al2O3 prepared by co-impregnation method. When combined with low temperature plasma technology, high-energy electron collision reaction and oxidation reaction between free radicals occurs, which played a synergistic role in the degradation of VOCs-O3. The total removal rate of xylene was 94.88%, and the depletion rate of ozone was 84.1%.
A case of near-fatal bleeding due to ruptured peripheral varicose veins as a consequence of previous orthopedic surgery
Authors: Takamatsu Jumpei , Nakamjima Hajime , Nakata Masatoshi , Fukuhara Aya , Kang Jinkoo , Yasue Yuichi
Published: April 2023

Background
Peripheral varicose veins are common condition. A rupture of an imperceptible varicose vein can cause a fatal hemorrhage. Patients should be informed that surgery can aggravate varicose veins and cause them to rupture in the lower extremities, which are prone to varicose vein formation.
Case presentation:
An 86-year-old male patient underwent open repair and fixation of a left ankle joint fracture 10 years prior to presentation. He had no specific symptoms; however, he suddenly began bleeding profusely from his left lower extremity during work and was rushed to the emergency room. He was in shock during transport; therefore, he was administered fluids and pressure hemostasis before arriving at the hospital. A 5 mm ulcer was observed in the left ankle joint, which was urgently removed after high-level ligation, including the varicose vein, and his circulation stabilized. The postoperative course was uneventful, the ulcer closed, and the patient was discharged on the second day. The histopathological examination revealed a suture in the outflow tract from the varicose vein that may have been caused by surgery to the previous left ankle joint fracture, and an organizing thrombus may have formed as a result.
Conclusions
We experienced a case of shock due to a varicose vein rupture with an unidentifiable bleeding point on site. This case highlights the necessity to inform patients with vein ligation about the possibility of varicose vein formation in the periphery and brings awareness to emergency staff who handle bleeding cases that a ruptured peripheral varicose vein could be the cause.
Prevalence and risk factors of urinary incontinence among women in Africa: a systematic review and meta-analysis
Authors: TORGBENU Eric , AIMAKHU Christopher O. , MORHE Emmanuel K. S. , AMEYAW Edward K.
Published: April 2023

Background Patients of urinary incontinence (UI), defined as an involuntary leakage of urine, mostly suffer in silence. African women with the condition usually feel embarrassed and may not readily seek help. In spite of this, there appears to be no recent systematic review that quantifies the prevalence and risk factors of UI. This study, therefore, synthesizes all studies that report the prevalence of UI and risk factors across African countries.Methods A systematic review and meta-analysis were conducted and reported in accordance with the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. Comprehensive search of Google Scholar, Hinari, African Journals Online (AJOL) and PubMed databases was conducted on July 24, 2020. The Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Prevalence Studies was used to assess the risk of bias. Summary measure was the prevalent percentage of women with UI, with 95% confidence intervals.Results Prevalence of urinary incontinence ranged from 0.61% (CI 0.9, 1.03) in Sierra Leone to 39% (CI 33.59–44.41) in Tanzania. The prevalence reported among women with gynaecological issues were between 20.2% (95% CI 16–24) and 39% (95% CI 34–44). Ten of the 14 studies reported on the risk factors of UI. The risk factors include multiparity, advanced gestational periods, mode of delivery, pregnancy related constipation, having an underlying respiratory condition during pregnancy, and having a high body mass index (BMI) or being overweight.Conclusion The study has revealed the discrepancy reported by various UI prevalence studies in Africa. Risk factors of UI including mode of delivery and age of women at latest delivery should be explored in further research. Enhancing treatment opportunities for UI among women will help to improve the lives of women living with UI.
Integrating Genomics into the Genetic Management of the Endangered Mountain Yellow-Legged Frog
Authors: Steiner Cynthia C. , Jacobs Leah , Choi Emma , Ivy Jamie , Wilder Aryn , Calatayud Natalie E. , Shier Debra M.
Published: April 2023

Conservation breeding programs have long been an important management tool for species recovery. Recently, breeding programs have begun to integrate next generation sequencing data into pedigree-based management strategies designed to maximize retention of genetic diversity and minimize inbreeding. The San Diego Zoo Wildlife Alliance established an ex situ breeding program for the endangered southern mountain yellow-legged frog (Rana muscosa), including two separately populations from the San Jacinto and San Bernardino mountain ranges. In this study, we conducted molecular population genetic assessments using double digest restriction site-associated DNA sequencing data to provide improved breeding recommendations for the managed R. muscosa populations. We found that genetic diversity of ex situ populations was relatively low (HO = 0.166–0.245) and population differentiation moderate (FST = 0.29). Patterns of genetic structure of captive frogs supported the evolutionary divergence of individuals by mountain ranges in the wild, with limited gene flow. Relatedness estimates identified close relatives among the founders, and molecularly-derived kinship values were used to determine and rank suitable breeders to minimize population mean kinship. Management recommendations highlight the need for importing additional founders from the wild to enhance genetic diversity in the breeding program, as effective source for genetic restoration.
Quark Confinement from different Dressed Gluon Propagators
Authors: Bedolla Marco A. , Raya Khépani , Raya Alfredo
Published: April 2023

The gap equation in quantum chromodynamics is solved by incorporating different gluon dressing functions, some of them derived from a quark-diquark potential that exhibits a conformal symmetry. By using the bare vertex and working in the Landau gauge, the quark mass function is found to have an infrared enhancement that smoothly transitions to an asymptotically free behavior at high momentum, which is consistent with the predictions of Schwinger-Dyson equations. Additionally, these quark propagators violate reflexion positivity, indicating that the gluon dressing provides clear evidence of quark confinement.
Variances of life expectancy estimations
Authors: Dang Phuc Ho , Nguyen Thanh Nga
Published: April 2023

Concerning the local parametric estimation method, a novel method of life expectancy estimation, the article derives a formula to calculate the variance of that estimation. Specifically, we provide the theoretical base of the variance formula, then prove the approximation to normal distribution of the life expectancy local parametric estimation. Extensive experiments with real-world datasets show that the local parametric method provides less biased estimation with lower variance in comparison to the Chiang method. This confirms the advantages of the new life expectancy estimation method over the Chiang estimation method. The lower variance of estimation allows the statistical tests to get the higher performance in detection of life expectancy estimation differences. The new life expectancy estimation method can be useful in the assessment of the health inequality in small area settings by conducting statistical tests.
Effect of operative positions during bariatric surgery on postoperative nausea and vomiting
Authors: Li zhaopeng , Song Yancheng , Tian Yaoyao , Li Yali , Yang Xiaojuan , Zhou Xia , Li Zhao , Liu Shuguang , Li Yu
Published: April 2023

Objective To explore the effect of operative positions during bariatric surgery on postoperative nausea and vomiting(PONV) .Methods The patients with obesity who underwent laparoscopic sleeve gastrectomy (LSG) in the hospital from June 2020 to February 2022 were divided into two groups and analyzed retrospectively. The multivariable logistic regression analyses and T test were used to study the influence for operative positions on PONV.Results There were 15 cases of PONV in the prone split-leg position group, with an incidence rate of 50%, and 11 cases of PONV in the supine position group, with an incidence rate of 36.7%(P = 0.297). The operation time in the prone split-leg position group was 168.23 ± 46.24 min and the anesthesia recovery time was 55.03 ± 21.392 min. The operation time in the supine position was 140.60 ± 32.256 min and the anesthesia recovery time was 44.60 ± 13.307 min. There were significant differences between the two groups(P༜0.05). Multivariable analysis showed that the operative positions was not an independent risk factor for PONV, with an OR of 1.192 ( 95%CI: 0.376–3.778, P = 0.766).Conclusions This study showed that the operative positions may affect the PONV. Although, the difference in the incidence of PONV was not significant. The operative positions should be carefully selected for the patients with obesity before surgery.
Financial Public Turbulency After Covid-19 Pandemic Pressure (CPP 19 ) : Study Case in Indonesia
Authors: Basmar Edwin , Salim Zamroni , Widiastuti Tika , Basmar Erlin
Published: April 2023

The Covid-19 pandemic has mutated with various types, we need a model for detect financial turbulence, heavy economic pressures in the form of financial instability and slowing economic growth in Indonesia. The collecting financial data process was obtained during the Covid 19 Pandemic from Bank Indonesia reports 2019 to 2022. Data processing used the Ed Waves Index the development model, which describes the financial cycle wave movement as a reaction form to the Covid-19 pandemic pressures in Indonesia, The study results found that there are three concepts of financial turbulency, first, the Covid-19 Pandemic Pressure (CPP19) which increases, the financial cycle moves negatively by -0.020 Amplitude. Second, the Covid-19 Pandemic Pressure (CPP19) is neutral, the financial cycle moves negatively by -0.009 Amplitude. Third, the decreasing the Covid-19 pandemic pressure (CPP19), the financial cycle moving positively by 0.022 Amplitude, all techniques have an impact on financial stability and economic growth in Indonesia.
JEL Classification: E32, E52, E58
Expression of p53 Combined with Ki-67 in IDH-wildtype Glioblastomas: Prediction by Apparent Diffusion Coefficient Values
Authors: Zhang Bin , Xue Caiqiang , Zhou Qing , Zhang Peng , Han Tao , Deng Liangna , Jing Mengyuan , Zhou Junlin
Published: April 2023

The presence of p53 mutationscombined with high Ki-67 expression can predict poor prognosis and overall survival in IDH-wildtypeglioblastoma patients. This study aims to use magnetic resonance imaging (MRI) features and apparent diffusion coefficient(ADC) values to predict the expression of p53 and Ki-67 in IDH-wildtype glioblastomas to informclinical treatment. We retrospectively collected clinical and imaging data for 103 IDH-wildtype glioblastoma patients in our hospital between June 2021 and February 2023. The datasets were divided into four groups: p53(+)/Ki-67(+), p53(+)/Ki67(-), p53(-)/Ki67(+), and p53(-)/Ki67(-) according to mutant status of p53 and expression level of Ki-67. Six MRI morphological features and four ADC values for the tumor parenchyma were analyzed. In the 103 patients, 21 had p53(-)/Ki-67(-), 12 had p53(+)/Ki-67(-), 28 had p53(-)/Ki-67(+), and 42 had p53(+)/Ki-67(+). Tumor location showed statistically significant differences among the 4 groups (P < 0.05). ADC parameters were negatively correlated with p53 and Ki-67 expression status and could distinguish the co-expression of p53 and Ki-67 (P < 0.05). In distinguishing between the p53(+)/Ki-67(+) and p53(-)/Ki-67(-) groups, when ADCmin was 0.85×10-3 mm2/s, the sensitivity, specificity and accuracy reached their maximum values of 61.90%, 92.90% and 82.54%, respectively. In conclusion, the expression of p53 and Ki-67 in IDH-wildtypeglioblastoma can be evaluated by ADC values. ADC values can be used as a non-invasive quantitative parameter to assist in the clinical diagnosis of IDH-wildtype glioblastoma molecular states.
Venous Blood Gases of Captive Red Foot Tortoise (Chelonoidis carbonarius)
Authors: de Freitas Sofia Silva La Rocca , Garcia Laís Velloso , Santos Jairo Antonio Melo dos , Hirano Líria Queiroz Luz
Published: April 2023

Blood gas analysis evaluates the exchange of oxygen and carbon dioxide in the lungs and provides important information since the state of balance of these gases directly influences the acid-basic balance of the body. Due to the necessity of blood gas parameter measurement for Brazilian reptiles, venous blood gas was determined in captive red foot tortoises. In the present study, 19 animals were used, 8 males and 11 females. Blood was obtained from the dorsal coccygeal vein from the tail, and the analysis was performed immediately after blood collection. The blood parameters pH, PO2, HCO3, TCO2, BEecf, Na, K, ICa, and Glu were compared between females and males, and the values of pH, pCO2, and pO2 were compared with and without temperature correction. A significant difference was observed for the saturation of oxygen and sodium levels between sexes, with higher mean values in males. Furthermore, it was possible to infer that the lower the body temperature in relation to the environment, the greater the pH difference with temperature correction.
Investigating the Role of Proximal Femoral Morphology in Non-Contact ACL Injuries: A Comparative Study
Authors: Musliu Dijon , Bexheti Sadi , Kida Qerim , Kafexholli Ardita , Jashari Redon , Shatri Jeton , Mahmuti Agron , Berisha Lavdim , Karakushi Ardian
Published: April 2023

Purpose: Non-contact ACL injury is a common and debilitating injury among athletes, with high rates of recurrence and long-term consequences. Identifying individuals who are at risk of ACL injury can help prevent or reduce the severity of these injuries. The aim of this study is to assess the role of alpha angle in patients with ACL rupture.
Methodology: This is a case-control study which includes a total of 105 subjects. Hip radiographs were taken in all the subjects using the modified Dunn View radiograph with patient in supine position, hip flexed 45o and abducted 20o. Osirix MD was used to analyse the radiographs and SPSS v.23 for statistical analysis.
Results: The majority of injuries were caused by football (58.1%), followed by jumping sports (23.8%) and skiing (18.1%). A mean difference of 5o of the alpha angle between the groups was measured. Statistical tests showed significant difference between the groups (p<0.001) and logistic regression showing 12-20% risk increase for every degree of alpha angle raise.
Conclusion: The findings showed a substantial correlation between higher alpha angles and an increased likelihood of ACL injury, with patients who ruptured their ACLs having higher mean alpha angles than those who did not. We recommend that young athletes who are actively participating in sports have their hip alpha angles measured so that those with higher alpha angle can follow special prevention programs.
Hypothermia rescued by veno-arterial extracorporeal membrane oxygenation: a case report
Authors: Chen Hao , Yuan Wei , Sun Xiangyou , Sun Yutian , Zhang Jing , Wu Haibo
Published: April 2023

Background: Severe hypothermia is a life-threatening condition that often causes hemodynamic instability or cardiac arrest and carries a high risk of mortality. The use of VA-ECMO in this indication has greatly improved the prognosis of patients.
Case presentation: We describe an incredible case involving the complete recovery of a 47-year-old man placed on VA-ECMO for cardiogenic shock and protracted ventricular fibrillation caused by hypothermia. The patient was discharged home in 20 days with no neurologic sequelae.
Clinical discussion: Extracorporeal life support (ECLS) with cardiopulmonary bypass (CPB) or extracorporeal membrane oxygenation (ECMO) has been recommended as the gold standard for the treatment of severe hypothermia due to its rapid availability and the possibility of prolonged support. Our case demonstrates the effectiveness of ECMO in treating patients with hypothermic cardiogenic shock. At the same time, nutritional support and rehabilitation therapy play an integral role in the whole treatment process. Therefore, it is recommended that such patients be managed by an experienced cardiac team that can evaluate the patient's condition in multiple aspects.
Conclusion: ECMO is effective in the treatment of cardiogenic shock caused by hypothermia.
Income Taxation and Dual Job labour Supply*
Authors: Choe Chung , Oaxaca Ronald , Renna Francesco
Published: April 2023

This paper examines the effects of increasing marginal tax rates on labour supply in a setting in which workers may hold two jobs and may be constrained in their weekly hours on their main jobs. A panel data, multi-equation labour supply model is estimated with correction for tax system endogeneity and multi-sample selection in a correlated random effects framework. Data come from the British Household Panel Survey. The effects of counterfactual increases in marginal tax rates are obtained from Gauss-Seidel simulations of labour supply embedded in a tax system with allowances, tax credits, and child benefits. Labour supply to the main job is reduced by increased marginal tax rates while labour supply to the second job is increased. On net total labour supply is reduced. These effects diminish with increased marginal tax rates. In addition there are labour force withdrawal effects as well as transitions from dual job holding to unitary job holding in response to increased marginal tax rates.
Effect of LiF‑introduced on electrochemical properties of carbon coated silicon suboxide anode material for lithium-ion batteries
Authors: Tang Zhenyuan , Zhang Zhengyu , Wu Jiani , Luo Qian , Lan Lifang , Li Jun
Published: April 2023

Though silicon suboxide (SiOx, 0<x<2) has been considered a new generation of anode material for lithium-ion batteries, the large volume expansion and intrinsic conductivity hinder its commercial applications. In this work, silicon dioxide (SiO2) was prepared via tetraethyl orthosilicate (TEOS) hydrolyzed, and lithium fluoride (LiF) was introduced in situ, and then SiO2/LiF was covered with pyrolyzed sucrose to obtain SiOx/LiF@C. Large elastic modulus, low solubility in a carbonate solution, and high chemical stability LiF was designed to induce the formation of a stable SEI layer on the electrode surface. The more stable interface minimizes the continuous growth of the SEI layer, thereby reducing the resistance and the irreversible decay of capacity. Compared with SiOx@C-3, the SiOx/LiF@C-3 anode displays better electrochemical performance, especially cycle performance at high current density. Benefiting from the cooperation of amorphous carbon coating and stable SEI layer, SiOx/LiF@C-3 activated by low current maintains a specific capacity of 504.2 mAh g-1 and a capacity retention rate of 96% after 300 cycles at a current density of 0.3 A g-1. The great potential of LiF‑introduced for silicon suboxide anode is demonstrated.
Effects of Bone marrow sparing radiotherapy on acute hematologic toxicity for patients with locoregionally advanced cervical cancer: a prospective phase II randomized controlled study
Authors: li wen , Ma Lan , Li Fang , Zhang Yang , Ren Hongtao , Bao Xing , Guo Yuyan , Guo Ya , Li Dan , Ma Xiulong , Wang Zhongwei , Wang Yali , Yin Rutie
Published: April 2023

Background and purpose: To evaluate effects of bone marrow sparing (BMS) radiotherapy on decreasing the incidence of acute hematologic toxicity (HT) for locoregionally advanced cervical cancer (LACC) patients treated by pelvic irradiation.
Materials and methods: LACC patients were recruited prospectively from May 2021 to May 2022 at a single center and were evenly randomized into the BMS group and the control group. All patients received pelvic irradiation with concurrent cisplatin (40 mg/m2 weekly), followed by brachytherapy and BM V40 <25% in the BMS group was additionally prescribed. Acute HT was assessed weekly. Binary logistic regression model and receiver operating characteristic (ROC) curve were used for predictive value analysis. The trial was registered with Chinese clinical trial registry (ChiCTR2200066485).
Results: A total of 242 patients were included in the analysis. Baseline demographic, disease and treatment characteristics were balanced between the 2 groups. In the intention-to-treat population, BMS was associated with a lower incidence of grade ≥2 and grade ≥3 acute HT, leukopenia and neutropenia (72.70% vs 90.90%, P <0.001*; 16.50% vs 65.30%, P <0.001*; 66.10% vs 85.10%, P = 0.001*; 13.20% vs 54.50%, P <0.001*; 37.20% vs 66.10%, P <0.001*; 10.70% vs 43.80%, P <0.001*). BMS also resulted in decreased dose delivered to the organs at risk (OARs) including rectum, bladder and left and right femur head. Univariate and multivariate analyses showed that BM V40 was an independent risk factor for grade ≥3 acute HT (odds ratio [OR] = 2.734, 95% confidence interval [CI] = 1.959-3.815, P <0.001*). Cutoff value was 25.036% and area under the curve (AUC) was 0.786. The nomogram was constructed, which was rigorously evaluated and internally cross-validated, showing good predictive performance.
Conclusions: Receiving BMS pelvic irradiation could reduce the incidence of acute HT in LACC patients, and BM V40 <25% may be a significant factor in reducing the risks of acute HT.
Outcomes for Potentially Resectable Patients Undergoing Primary Chemoradiation Treatment for T1 – T2 HPV Negative Oropharyngeal Squamous Cell Carcinoma
Authors: Laxague Francisco , Fnais Naif , Son Hee Young , Alzahrani Faisal , Mymryk Joe S. , Barrett John W. , Tay Keng Yow , Leung Andrew , Theurer Julie , Nichols Anthony C. , Palma David A.
Published: April 2023

Background
A previous study in HPV-positive patients have shown that transoral surgical resectability (TOS) is a strong prognostic factor for patients with T1-2 disease undergoing radiotherapy (RT), but it is unclear whether this holds for HPV-negative patients, in whom the biology is different and outcomes are worse. We aimed to compare outcomes of potential TOS-candidates vs. non-TOS candidates, among patients who underwent RT/CRT for early T-stage human papillomavirus-negative (HPV-negative) OPSCC.
Methods
For patients treated with RT/CRT for early-stage HPV-negative OPSCC between 2014 and 2021, pretreatment imaging was reviewed by four head-and-neck surgeons, blinded to outcomes, to assess primary-site suitability for TOS, and extracapsular extension (ECE) was assessed by a head-and-neck neuroradiologist. We compared outcomes based on surgical resectability relating to: 1) the primary site tumor alone, and 2) the primary site plus the absence/presence of ECE (overall assessment). Kaplan-Meier curves for overall survival (OS), disease-specific survival (DSS), and progression-free survival (PFS) were compared using the log-rank test, with Cox regression for multivariable modeling.
Results
Seventy patients were included in the analysis. The mean age was 63.1 years and the majority of the patients were male 39/70 (55.7%). The primary site was TOS-favorable in 46/70 (66%). Based on the overall assessment (including the primary site and positive lymph nodes), 41/70 (58.6%) were TOS-favorable. The 3-year OS, DSS and PFS for primary site TOS-favorable vs. unfavorable were OS: 76.9% vs. 37.4%; DSS: 78.1% vs 46.2%, PFS: 69.9% vs 41.3%, (log-rank test = 0.01, 0.03, 0.04; respectively). Additionally, patients with an overall assessment of TOS favorability demonstrated better survival outcomes compared with TOS-unfavorable patients (OS: 77.3% vs. 46.2%; DSS: 78.2% vs. 56.5%, PFS: 72.3% vs. 42.1%, log-rank test = 0.01, 0.04, 0.01; respectively).
Conclusion
Patients with TOS-favorable HPV-negative early T-stage OPSCC have superior survival outcomes than TOS-unfavorable patients. This critical confounder needs to be considered when comparing primary surgical and primary radiation clinical trials and retrospective studies.
Oncolytic adenovirus H101 enhanced antitumor effects of PD-1 blockade by downregulating CD47 on tumor cells
Authors: Qiao Chenxiao , Wang Song , Xu Yipeng , He Yedie , Cai Zhijian , Wang Hua
Published: April 2023

Programmed cell death protein 1/programmed cell death ligand 1 (PD-1/PD-L1) blockade are standard of care for many patients with advanced or metastatic cancer. However, a majority of patients remain resistant to these treatments. It has been reported that local oncolytic viral infection of tumors is capable of overcoming systemic resistance to PD-1 blockade, and strongly suggest the combination therapy of virotherapy with PD-1 blockade to improve therapeutic efficacy in tumors that are refractory to checkpoint blockade. We investigate the antitumor effects of an E1B55KD deleted oncolytic adenovirus H101, in combination with a humanized anti-PD-1 monoclonal antibody Camrelizumab on cancer. Combination of H101 with Camrelizumab demonstrated more potent antitumor effects than monotherapy in immune system humanized NSG mice subcutaneous (S.C.) tumor model. Increased tumor infiltrating T cells including the total and IFN-γ-expressing CD8+ T cells in the combination treatment group were observed. H101 infection induced decreased expression of CD47 on cancer cells, thereby promoting macrophage to phagocytose cancer cells. With the activation of macrophage by H101, increased levels of cytokines including TNF, IL-12 and IFN-γ were observed when induced THP-1 cells were co-cultured with H101-treated cancer cells, which further induced increased expressions of IFN-γ in T cells. Eliminating the IL-12 by anti-IL-12 neutralizing antibodies abolished IFN-γ production from T cells, showing activation of macrophages by H101 induced oncolysis to promote IFN-γ secretion of T cells via IL-12. Meanwhile, infection with H101 induced upregulation of PD-L1 on YTS-1 cells. These results suggested that H101 works synergistically to enhance therapeutic efficacy of PD-1 blockade on cancer by suppressing CD47 signaling, which may promote phagocytose of macrophages to tumor cells and activate CD8+ T cells. Combination of H101 with PD-1 blockade would be a novel strategy for treating cancer.
Li-ion conduction in novel Scandium and Gallium doped Li 1.3 Al 0.29 Ga 0.005 Sc 0.005 Ti 1.7 (PO 4 ) 3 NASICON compound
Authors: Kothari Dharmesh H. , Kanchan D. K. , Kumar Deepak , Chaudhari Ketan
Published: April 2023

Li1.3Al0.3Ti1.7(PO4)3 (LATP) has a high Li+ conductivity of ~ 10− 3 S/cm which can be employed as an inorganic solid electrolyte for solid state batteries. Here we report the electrical properties of gallium and scandium doped forms of LATP viz. Li1.3Al0.3Ti1.7(PO4)3 (LATP), Li1.3Al0.29Ga0.01Ti1.7(PO4)3 (LAGTP) and Li1.3Al0.29Sc0.01Ti1.7(PO4)3 (LASTP) and Li1.3Al0.29Ga0.005 Sc0.005Ti1.7(PO4)3 (LAGSTP). All the samples were prepared by solid state reaction method. Structural characterization was carried out using X-ray diffraction (XRD) and Fourier Transform Infrared (FTIR) techniques whilst electrical properties were studied using Electrochemical Impedance Spectroscopy (EIS). It was found that the larger cations Ga3+ and Sc3+ at octahedral sites change the Ti–O–P bond angle in LTP lattice. This distortion of lattice on ion-ion correlation and subsequently on Li+ ion conduction in the novel LAGSTP material was found to decrease the Li+ ion conductivity to ~ 10− 5 S/cm.
Handy App for Safety Against Violence
Authors: Janokar Sagar , Gaikwad Vijay , Ghuge Siddhant , Ghorpade Sakshi , Gholap Sanveda , Ghuge Pranjal , Ghule Ojasvi
Published: April 2023

Heinous offenses against women have forced us to undertake many precautionary measures and put on a large array of ideas so that to provide security systems to women via their phones. Here we present, an Android Application for women safety, this app can be activated by just normal movements like shaking, as situation demands. Our main agenda is to create a model that removes the financial and physical complexities in GPS, since it is a satellite-based service alongside being available anytime anywhere. GPS system can come handy to extract data which contains parameters like latitude, longitude along with the time details, etc. There exists no prior financial investment for its usage. ’Google Maps’ is a popular service for this purpose. Mobile phone catches hold of location which communicates with the help of General Packet Radio Service (GPRS), being one of the superior modes as far as tracking concerned.
Comparison of Median, Intermediate, and Lateral Approach in the Ultrasound-Guided Sacral Erector Spinae Plane Block: A Cadaveric and Radiologic Study
Authors: KELEŞ Bilge OLGUN , SALMAN Necati , YILMAZ Elvan TEKİR , BİRİNCİ Habip Resul , APAN Alparslan , İNCE Selami , ÖZYAŞAR Ali Faruk , UZ Aysun
Published: April 2023

Backgrounds: Erector spinae plane block (ESPB) has become very popular for post-operative and chronic pain management. It is aimed to observe the contrast agent distributions of three different methods anatomically and radiologically in ultrasound-guided sacral ESPB interventions.Materials and Methods: Six cadavers were enrolled and they were grouped into three groups; median, intermediate, and lateral approaches. An ultrasound-guided ESPB was performed with a mixture of radio-opaque and dye. After 30 minutes, the distribution of the solution was observed in the cadavers by computed tomography (CT) examination. Totally after 60 minutes of intervention, the median and intermediate groups of cadavers were dissected in order to observe the dye spread in the median group and the intermediate group. The lateral group dissection wasn’t performed according to radiologic findings.Results: CT images presented a pooling of the radio-opaque at subcutaneous tissue in the median group, at erector spinae in the intermediate group, and at gluteus maximus in the lateral group of cadavers. In addition to compartment spreads, images presented anterior transition of the contrast agent at only median group cadavers. Dissection findings presented pooling of the methylene blue at subcutaneous tissue between S1 and S5 horizontal planes at the median group. The red acrylic paint spread was detected between L2-S3 levels in the erector spinae muscle group.Conclusion: Radiocontrast dye was detected at superficial, erector spinae, and gluteus maximus compartments respectively at median, intermediate, and lateral cadaver groups both radiological and anatomically. Anterior transition of the radiocontrast was detected in only the median cadaver group.
Camrelizumab plus taxanes and cisplatin (TP) chemotherapy or TP chemotherapy in patients with recurrent or metastatic nasopharyngeal carcinoma
Authors: Liu Jingyu , Bao Yuqing , Zhu Lisheng , Xiong Ying , Shi Liangliang , Hong Xiaohua , Peng Gang
Published: April 2023

BackgroundThe addition of immune checkpoint inhibitors (ICIs) to platinum-based chemotherapy has shown promising antitumor activity in patients with recurrent or metastatic nasopharyngeal carcinoma (RM-NPC), who have poor survival outcomes. We therefore compared the efficacy and adverse events of taxanes-cisplatin (TP) chemotherapy and camrelizumab plus TP chemotherapy in patients with RM-NPC.Materials and methodsIn this retrospective study, we collected the medical records of 194 patients with RM-NPC between June 30, 2019, and December 31, 2021. The patients received camrelizumab plus TP chemotherapy or TP chemotherapy alone as first-line treatment at Wuhan Union Hospital Cancer Center. The survival outcomes, efficacy, and treatment-related adverse reactions were compared between the groups.ResultsThe medical records of 194 patients with RM-NPC were reviewed. Compared with the TP group, patients in the camrelizumab plus TP group had a longer median progression-free survival (PFS) (13.4 vs. 9.5 months; hazard ratio (HR) 0.628 [95% confidence interval (CI) 0.432–0.912];P = 0.015) and overall survival (OS) (73.91% vs. 57.84%; HR 0.544 [95% CI 0.336–0.878];P = 0.013). The results of multivariate analysis indicated that Epstein-Barr virus DNA (EBV DNA) load in plasma before treatment was an independent prognostic indicator associated with PFS (HR 0.488 [95% CI 0.336–0.709];P < 0.001) and OS (HR 0.602 [95% CI 0.372–0.976];P = 0.040)ConclusionOur study revealed that adding camrelizumab to taxanes-cisplatin chemotherapy showed a higher PFS and OS in patients with recurrent or metastatic nasopharyngeal carcinoma and had a manageable safety profile.
A Robust Fish Species Classification Framework: FRCNN-VGG16-SPPNet
Authors: Chen Mei-Hsin , Lai Ting-Hsuan , Chen Yao-Chung , Chou Tien-Yin , Ning Fang-Shii
Published: April 2023

This study proposes a novel framework for fish species classification that combines FRCNN (Faster Region-based Convolutional Neural Network), VGG16 (Visual Geometry Group 16), and SPPNet (Spatial Pyramid Pooling network). The proposed FRCNN-VGG16-SPPNet framework combines the strengths of FRCNN's fast object detection and localization, VGG16's convenient transfer learning and fast classification performance, and SPPNet's image processing flexibility and robustness in handling input images of any size. First, FRCNN is used to detect and extract target objects from images containing multiple objects. Subsequently, photos of various fish species at different scales are fed into VGG16-SPPNet, which performs basic feature extraction using transfer learning theory. SPPNet further processes the input images by performing pooling operations of different scales. Finally, VGG16 identifies important features to perform object classification. The proposed framework achieves higher accuracy compared to traditional single VGG16 models, particularly in classifying objects of different sizes, with an accuracy rate of 0.9318, which is 26% higher than traditional single VGG16 models. The proposed framework is efficient, convenient, reliable, and robust for object classification and has potential for various applications in image recognition and classification.
Isolation and identification of native yeasts from the spontaneous fermentation of grape musts.
Authors: Gerard Liliana Mabel , Corrado María Belén , Davies Cristina Verónica , Soldá Carina Alejandra , Dalzotto María Gabriela , Esteche Sofía
Published: April 2023

Recently, there has been growing interest in the characterization of native yeasts for their use in production of wines with regional characteristics. This study aimed to investigate Saccharomyces and non-Saccharomyces yeasts present in the spontaneous fermentation of Tannat and Marselan grape musts collected from Concordia (Entre Ríos, Argentina) over 2019, 2020, and 2021 vintages. The evolution of these fermentative processes was carried out by measuring total soluble solids, total acidity, volatile acidity, pH, ethanol concentration, and total carbon content. Isolated Saccharomyces and non-Saccharomyces yeasts were identified based on colony morphology in WL medium, 5.8S-ITS-RFLP analysis, and 26S rDNA D1/D2 gene sequencing. Two hundred and ten yeast colonies were isolated and identified as Pichia kudriavzevii, Saccharomyces cerevisiae, Hanseniaspora uvarum, Metschnikowia pulcherrima, Candida albicans, Candida parasilopsis, Pichia occidentalis, Pichia bruneiensis, Hanseniaspora opuntiae, Issatchenkia terricola, and Hanseniaspora vineae. P. kudriavzevii isolated from all vintages was associated with the spontaneous fermentation of grape musts from the Concordia region.
Almost a Hilbert Space
Authors: Mupasiri Douglas , G{\"u}l Erdal , Williams Daniel , Gill Tepper
Published: April 2023

Kuelbs \cite{K} has shown that every infinite-dimensional separable Banach space $\mathcal{B}$ can always be densely and continuously embedded in a separable Hilbert space $\mathcal{H}$. If $\mathcal{L}[\mathcal{B}]$ is the set bounded linear operators on $\mathcal{B}$, in this paper we prove the following: \begin{enumerate}\item For each $u \in \mathcal{B}$, there exists a semi-inner product $[\, \cdot, u]_z$ generated by bounded linear functional $u_z^* \in \mathcal{B}^*$ and a constant $c_u$ such that $u_z^*(v)=[v,u]_z= c_u(v , u)_\mathcal{H}$ for every $v \in \mathcal{B}$.\item If $\mathbb{A} \ne \mathcal{B}$ is closed, there exists $\mathbb{A}^\bot \subset \mathcal{B}$ disjoint, and $\mathcal{B} = \mathbb{A} \oplus \mathbb{A}^ \bot$.\item For $A \in \mcL[\mathcal{B}]$ there exists $A^* \in \mcL[\mathcal{B}]$ and $(A^*A)^*=A^*A$.\item $\mathcal{L}[\mathcal{B}] \subset \mathcal{L}[\mathcal{H}]$ as a continuous dense embedding.\item $\mathcal{B} \times \mathcal{B}^*$ has an Auerbach basis.\item Every compact operator on $\mathcal{B}$ is the limit of operators of finite rank without assuming that $\mathcal{B}$ has a Schauder basis.\item The Schatten class $\mathbb{S}_p [\mathcal{B}]$ exists for each $p \in [1, \iy]$, $\mathbb{S}_p [\mathcal{B}] \subset \mathbb{S}_p [\mathcal{H}]$ as a continuous dense embedding, $\bar{A} \in \mathbb{S}_p [\mathcal{H}]$ if and only if its restriction $A \in \mathbb{S}_p [\mathcal{B}]$, and ${\left\| {\bar A} \right\|_p^\mathcal{H}} = {\left\| A \right\|_p^\mathcal{B}}$. \end{enumerate}
WITHDRAWN: Do the Non-verbal Behaviors of Sprinters Before the Competition Affect Their Performance?
Authors: ERKAN Dilara , BAYRAKTAR Işık , BİÇER Ayşe Sibel
Published: April 2023

In athletics, the athlete is expected to get their concentration and control his negative emotions before the start. Body language of athletes can give important clues about their "real" internal states. On account of, it is important to analyze the nonverbal behaviors of the athletes before the start. In line with this importance, the aim of this study is to analyze the pre-start nonverbal behaviors of the athletes by coding them with the "Body Action Posture Coding System" and to examine the effect on the performance of the athletes. As a result, with this thesis study, it has been revealed that some nonverbal behaviors of the athletes, affect their performance. Nonverbal behaviors can give clues about the mental state of the athlete as well as give clues about the result of the competition has been opened to discussion with this study.
Scientific networks of Miodrag Grbić and their influence upon Serbian archaeology
Authors: Bandović Aleksandar
Published: April 2023

In order to understand the creation, spread, adoption, and maintenance of scientific ideas, it is productive to study scientists in relation to their contemporaries. The studies in sociology of science indicate that the informal level of personal communication makes up a substantive part of scientific life. Scientists build various strategies, find confirmation for their ideas, or fortify their position through personal communication. Driven by various interests, scientists form networks of interaction. The analysis of personal correspondence of Miodrag Grbić (1901–1969), archaeologist and custodian of the National Museum in Belgrade, offers insight into the less known, but important details of the history of Serbian/Yugoslav archaeology. The activity of Grbić becomes considerably more comprehensible when observed in its context, in the light of international scientific networks. The ideas he shared in this framework will become apparent during the World War II, to gain their final shape in the form of Museum Course. From a wider perspective, major important themes of culture-historical archaeology under the specific political circumstances of Europe between the wars, may be discerned beyond the scientific networks of Grbić.
Eschatological debate on the future of anthropology. Concept of crisis of anthropology in proceedings “The End of Anthropology”
Authors: Ignjatović Suzana
Published: April 2023

The paper deals with the current concept of “anthropology in crisis”, based on the collection ofpapers “The End of Anthropology”, dedicated to this particular issue. The positions presented in this book are used as a starting point for further discussion about the crisis discourse in anthropology. The paper critically examines the identified sources of crisis (interdisciplinarity, professionalization, etc) but also refers to other aspects of crisis that should be further discussed (relativism, applied anthropology, political aspects of anthropology).
Love in the time of the post-apocalypse – ways of imagining love after the end of the world
Authors: Banić Grubišić Ana
Published: April 2023

The paper deals with ways of representing love and amorous relationships in post-apocalyptic movies. In these movies, there is a dualism of romantic and partner love, and these two types of love are there to help build a new world, or rebuild the destroyed society. These images of love emphasize the importance of evolutionist theories for the central ideas of these films – in post-apocalyptic scenarios love mostly serves the purpose of having or protecting progeny, it is represented as the key tool and mechanism of survival.
Semiological analysis of Polish theater posters
Authors: Nikolić Jelena , Nedeljković Uroš
Published: April 2023

Through the application of semiological analysis to theater posters made by two Polish authors, the paper uncovers signs, meanings, codes and specifics of the “Polish school of poster-making” and contemporary Polish posters. Aside from this, I suggest a methodological framework for studying the issue of coding and shaping a theater poster as a culturally specific form of visual communication. The aesthetic and semiotic outlook of the Polish theater posters which were chosen is analyzed using the semiological method which highlights their differences and similarities. By pointing out the system of codes through the examples given here, a graphic designer is informed about the existence and the possibilities of a more systematic approach to shaping a theater poster.
The Role of Pre-Pandemic Investments in the Health Sector, Additional Fiscal Measures and Anti-Epidemic Policies in the Suppression of COVID-19: The Case of 15 Developed Countries
Authors: Radonjić Ognjen
Published: April 2023

The paper seeks to identify the causes of the significant differences in the efficiency of the response to the COVID-19 pandemic between 15 developed countries. Geographic location, pre-pandemic investment in healthcare system capacity for preventing and managing the epidemic suppression process, and additional fiscal spending (which, in addition to public health investment, includes support measures for the economy) did not significantly affect the coronavirus mortality rate. In order to obtain a more accurate answer regarding the link between additional fiscal spending and the coronavirus mortality rate, we have specifically analyzed the role of the vaccination rate in the entire population because vaccine production is significantly funded through additional fiscal spending, while vaccine distribution is entirely funded through additional fiscal spending. We conclude that the overall vaccination rate has a significant impact on the COVID-19 mortality rate, i.e. that there is a negative correlation between the two. Moreover, countries that responded efficiently to the pandemic timely implemented anti-epidemic measures following the recommendations of the World Health Organization; they were characterized by a high level of public confidence in government measures and had clear and transparent communication with their citizens. With regard to economic activity, we also definitely conclude that countries with a below average mortality rate, which timely implemented strict anti-epidemic measures following WHO recommendations and had clear and transparent communication with their citizens, experienced without exception a milder decline in GDP in 2020 than average, which suggests that the best way to preserve economic activity is to preserve human lives. Regarding the relationship between additional fiscal spending and unemployment trends, we conclude that most countries with a below average mortality rate had additional fiscal spending below average and a minority of countries above average, but also that all countries, with the exception of Australia, had a below average rise in the unemployment rate.