bluuebunny/crossref_metadata_2025 huggingface dataset:
Transcriptional Activation of the Human Immunodeficiency Virus Long Terminal Repeat Sequences by Retinoic Acid in Human Epithelial and Fibroblast Tumor Cell Lines
Authors: Zoumpourlis V. , Ergazaki M. , Spandidos D.A.
Published: April 2018

We employed a recombinant plasmid, pBHIV1, carrying the long terminal repeat (LTR) sequences of HIV-1 linked to the reporter chloramphenicol acetyl transferase (CAT) gene and to the aminoglycoside phosphotransferase (aph) gene as a selectable marker. We introduced pBHIV1 into human epithelial and fibroblast tumor cell lines (HeLa and MRCSV40TGR), and obtained stable geneticin-resistant HLHIV1-A and SVTGHIV1-A cells, respectively. The response to the retinoic acid was studied on the LTR regulated CAT activity in both cell lines. It was found that retinoic acid at a concentration of 1×10−5 effects a 3.2 - fold increase in CAT expression compared to HIV LTR in HLHIV1-A, but requires a concentration of 5×10−5 M to enhance this expression 4.6-fold in SVTGHIV1-A cells. These data show that retinoic acid may play a critical role in HIV-1 expression in human epithelial and fibroblast cell lines.
The Clinical Value of Cyfra 21-1 Estimation for Lung Cancer Patients
Authors: Szturmowicz M. , Sakowicz A. , Rudzinski P. , Zych J. , Wiatr E. , Zalęska J. , Rowinska-Zakrzewska E.
Published: April 2018

Cytokeratin-19, one of the cytoskeletal proteins, is expressed both in bronchial epithelium and in lung cancer cells. The aim of our study was to establish the value of serum cytokeratin-19 soluble fragment (Cyfra 21-1) measurement in lung cancer patients. Cyfra 21-1 levels were estimated in 35 patients (pts) with benign lung diseases and in 116 lung cancer patients: 55 pts with squamous cell lung cancer, 38 pts with small cell lung cancer and 23 pts with adenocarcinoma. The cutoff level was set at 4 ng/ml with a specificity of 94% and a sensitivity of 40%. Elevated Cyfra 21-1 values were found in 44% of squamous cell lung cancer, 39% of adenocarcinoma and 34% of small cell lung cancer pts (the difference was not significant). In squamous cell lung cancer and in adenocarcinoma elevated Cyfra 21-1 values were observed more often in patients with advanced disease than in patients with limited disease. There was no significant correlation between the initial Cyfra 21-1 level and the response to chemotherapy. Cyfra 21-1 was hot a prognostic indicator, although in operable squamous cell lung cancer the proportion of survivors in the second year of observation was higher among the patients with normal preoperative Cyfra 21-1 levels.
Are Diabetic Metabolic Compensation and CA19.9 Really Correlated?
Authors: Banfi G. , Ardemagni A. , Bravi S. , Pacchioni M. , Bonini P.
Published: April 2018

Diabetes has been claimed to be a risk factor for pancreatic carcinoma, but it is probably a consequence of gland invasion from the neoplastic tissue. A link between diabetes and pancreatic carcinoma was suggested by means of biochemical markers of the diseases, namely glycated hemoglobin and CA19.9. Moreover, CA19.9 was proposed as a sensitive and useful marker of the severity of exocrine damage in diabetes, since the mucin decreased when metabolic compensation improved. We examined 64 diabetic patients (36 insulin dependent, 16 non insulin dependent, 12 treated with diet) by measuring CA19.9 using two different immunometric methods and glycemia and glycated hemoglobin. We observed that a correlation between CA19.9 and biochemical markers of metabolic compensation of diabetes was inexistent and no differences between insulin dependent and non insulin dependent patients were found. A high concentration of CA19.9 in a diabetic patient should be interpreted and evaluated in the same manner as for a non diabetic patient.
Clinical Significance of Preoperative Serum Levels of CA 125 and TAG-72 in Ovarian Carcinoma
Authors: Gonzalez A. , Vizoso F. , Vázquez J. , Ruibal A. , Balibrea J.L.
Published: April 2018

In a prospective study we evaluated in 48 patients with primary ovarian carcinoma the prognostic value of the preoperative circulating serum levels of CA 125 and TAG-72. Serum levels of CA 125 were above the cutoff level of 35 U/ml in 68% of patients, TAG-72 levels were higher than 6 U/ml in 50% of patients, while the simultaneous use of the two markers increased the sensitivity to 75%. Pretreatment CA 125 and TAG-72 levels were significantly lower (p < 0.05, for both) in patients with well differentiated tumors than in those with moderate or poor differentiation. Similarly, both marker levels were significantly higher (p < 0.001) in patients with residual disease after cytoreductive surgery than in those with no residual tumor. In addition, the CA 125 levels were also higher in initial stages (I-II) than in more advanced stages (III-IV) (p < 0.05), whereas TAG-72 levels were higher (p < 0.05) in patients with mucinous or endometrioid tumors than in those with serous carcinomas. The results further indicated that high preoperative serum levels of CA 125 and TAG-72 were associated with a shorter overall survival (p < 0.001 and p < 0.01, respectively). Finally, separate Cox multivariate analysis showed that preoperative CA 125 and TAG-72 serum levels were, after stage, the strongest factors to predict overall survival (p < 0.0001, p < 0.05 and p < 0.005, respectively) in patients with ovarian carcinoma.
Chromogranin a Measurement in Neuroendocrine Tumors
Authors: Ferrari L. , Seregni E. , Martinetti A. , Van Graafeiland B , Nerini-Molteni S. , Botti C. , Artale S. , Cresta S. , Bombardieri E.
Published: April 2018

Neuroendocrine tumors (NETs) are rare neoplasms characterized by a low proliferative index and, in some cases, a favorable prognosis. These tumors often overproduce and release biologically active substances that are responsible for severe syndromes. Tumor marker measurement provides the clinician with useful information for the management of NET patients. The substances released by overproducing tumors are currently used as biomarkers, but there is a need for sensitive markers also for the “biochemically silent” NETs. The most effective and reliable blood marker available today is chromogranin A (CgA). Because of its high sensitivity and specificity, this glycoprotein can be used for the diagnosis, prognosis and follow-up of NETs. Furthermore, CgA measurement can be used for monitoring those tumors not overproducing or releasing any hormones or biological amines. This paper is a synthetic review on the value of CgA in NET management and reports our experiences with CgA measurement in NET patients.
Raw Power: Punk, DIY and Underground Cultures as Spaces of Resistance in Contemporary Portugal
Authors: Guerra Paula
Published: April 2018

This article focuses on presenting, analysing and understanding the ‘do-it-yourself’ (DIY) representations of over 200 participants in Portuguese punk music scenes between 1977 and 2014. Through an ethnographic study of punk and the DIY ethos in Portugal, the article depicts its local interpretation and significance, and highlights the singularities of this socio-historical context. Our approach has three focal points: (1) the importance of DIY punk manifestations in the development of youth (sub)cultures, including forms of production and consumption of music, fashion, aesthetics, leisure, the night and cosmopolitanism; (2) the singularity of DIY punk manifestations in Portugal and related resistance practices in their correlation with social, political and economic development in a country outside the Anglo-Saxon context; and (3) the embedding of a DIY ethos and the associated claim to authenticity in the professions and careers in which punks engage today.
Can Patients Practice Strenuous Sports After Uncemented Ceramic-on-Ceramic Total Hip Arthroplasty?
Authors: Bonnin Michel P. , Rollier Jean-Charles , Chatelet Jean-Christophe , Ait-Si-Selmi Tarik , Chouteau Julien , Jacquot Laurent , Hannink Gerjon , Saffarini Mo , Fessy Michel-Henri
Published: April 2018

Background:

Patients are often concerned about returning to sports after total hip arthroplasty (THA).

Purpose:

To (1) evaluate sports participation and motivation rates in a large cohort of patients who underwent uncemented THA with ceramic-on-ceramic bearings and (2) determine whether patients’ participation was associated with their motivation for each sport, preoperative demographics, or patient-reported outcomes.

Study Design:

Case-control study; Level of evidence, 3.

Methods:

We surveyed 1310 patients (aged <75 years) who underwent uncemented ceramic-on-ceramic THA and collected levels of motivation and participation for 22 different sports as well as patient-reported outcome measure scores. A total of 1042 patients (1206 hips) returned questionnaires; the mean age at index surgery was 60.6 ± 8.8 years.

Results:

At least 51% of patients participated regularly or frequently in at least 1 light sport, 73% in at least 1 moderate sport, and 20% in at least 1 strenuous sport. Sports participation was strongly correlated with motivation ( r = 0.97, P < .001) but not with level of discomfort ( r = 0.22, P = .292). Participation in strenuous sports was significantly associated with age, body mass index, and sex. There were significant differences among patients who practiced various categories of sports as determined using the Oxford Hip Score ( P = .008), but not with regard to the Forgotten Joint Score ( P = .054).

Conclusion:

Only 20% of patients practiced strenuous sports regularly or frequently after THA, regardless of pain or discomfort. Participation in sports after THA is strongly correlated with motivation but not with level of discomfort. Longer term studies with a greater focus on complications and survival are necessary to determine whether high-impact sports compromise patient safety or implant longevity.
Forecasting, impact analysis and uncertainty propagation in regional integrated models: A case study of Australia
Authors: Masouman Ashkan , Harvie Charles
Published: April 2018

The integration of input–output and econometric models at regional level has gained popularity for its superior performance in forecasting employment and examining the impacts of policies. There are a number of approaches to integrate the two models. This paper examines the integration of input–output with econometric modelling using two merging methodologies, namely coupling and holistic embedding. Each methodology is analysed with respect to the accuracy of its results of total and sectoral employment forecasting. Both methodologies are applied to a regional economy in Australia. The methodology which shows superior forecasting accuracy is applied to examine the significance of sectors that generate the highest number of employments relative to other sectors.
Imaging the Deep Choroidal Vasculature Using Spectral Domain and Swept Source Optical Coherence Tomography Angiography
Authors: Diaz J. Daniel , Wang Jay C. , Oellers Patrick , Lains Inês , Sobrin Lucia , Husain Deeba , Miller Joan W. , Vavvas Demetrios G. , Miller John B.
Published: April 2018

Purpose:

To evaluate the deeper choroidal vasculature in eyes with various ocular disorders using spectral domain (SD) optical coherence tomography angiography (OCTA) and swept source (SS) OCTA.

Methods:

Patients underwent OCTA imaging with either SD-OCTA (Zeiss Cirrus Angioplex or Optovue AngioVue) or SS-OCTA (Topcon Triton). Retinal pigment epithelium (RPE) integrity, structural visualization of deep choroidal vessels on en face imaging, and OCTA of deep choroidal blood flow signal were analyzed. Choroidal blood flow was deemed present if deeper choroidal vessels appeared bright after appropriate segmentation.

Results:

Structural visualization of choroidal vessels was feasible in all eyes by en face imaging. In both SD-OCTA and SS-OCTA, choroidal blood flow signal was present in all eyes with overlying RPE atrophy (100% of eyes with RPE atrophy, 28.6% of all imaged eyes, P < .001).

Conclusions:

While choroidal vessels can be visualized anatomically in all eyes by en face imaging, choroidal blood flow detection in deep choroidal vessel is largely restricted to areas with overlying RPE atrophy. Intact RPE acts as a barrier for reliable detection of choroidal flow using current OCTA technology, inhibiting evaluation of flow in deeper choroidal vessels in most eyes.
Extreme enrichment of selenium in the Apliki Cyprus-type VMS deposit, Troodos, Cyprus
Authors: Martin Andrew J. , McDonald Iain , MacLeod Christopher J. , Prichard Hazel M. , McFall Katie
Published: April 2018

The Troodos ophiolite Cyprus hosts the type locality for Cyprus-type, mafic volcanogenic massive sulfide (VMS) deposits. Regional soil geochemical data for Troodos are highly variable with the Solea graben, one of three regional graben structures on Cyprus, showing enrichment in Te and Se. Of the three VMS sampled within the Solea graben, Apliki exhibits the most significant enrichment in Se. Samples from the South Apliki Breccia Zone; a zone of hematite-rich breccia containing euhedral pyrite and chalcopyrite, contain up to 4953 and 3956 ppm Se in pyrite and chalcopyrite, respectively. Four paragenetic stages are identified at Apliki and different generations of pyrite are distinguishable using trace-element chemistry analysed via laser ablation inductively coupled plasma mass spectrometry. Results indicate stage I pyrite formed under reduced conditions at high temperatures >280°C and contains 182 ppm (n = 22 σ = 253) Se. Late stage III pyrite which is euhedral and overprints chalcopyrite and hematite is enriched in Se (averaging 1862 ppm; n = 23 σ = 1394). Sulfide dissolution and hematite formation displaced large amounts of Se as hematite cannot accommodate high concentrations of Se in its crystal structure. The mechanisms proposed to explain the pronounced change in redox are twofold. Fault movement leading to localized seawater ingress coupled with a decreasing magmatic flux that generated locally oxidizing conditions and promoted sulfide dissolution. A Se/S ratio of 9280 indicates a probable magmatic component for late stage III pyrite, which is suggested as a mechanism explaining the transition from oxidizing back to reduced conditions. This study highlights the significance of changes in redox which promote sulfide dissolution, mobilization and enrichment of Se.
Bulbar impairment score and survival of stable amyotrophic lateral sclerosis patients after noninvasive ventilation initiation
Authors: Sancho Jesús , Martínez Daniel , Bures Enric , Díaz José Luis , Ponz Alejandro , Servera Emilio
Published: April 2018

There is general agreement that noninvasive ventilation (NIV) prolongs survival in amyotrophic lateral sclerosis (ALS) and that the main cause of NIV failure is the severity of bulbar dysfunction. However, there is no evidence that bulbar impairment is a contraindication for NIV. The aim of this study was to determine the effect of bulbar impairment on survival in ALS patients with NIV.

ALS patients for whom NIV was indicated were included. Those patients who refused NIV were taken as the control group.

120 patients who underwent NIV and 20 who refused NIV were included. The NIV group presented longer survival (median 18.50 months, 95% CI 12.62–24.38 months) than the no-NIV group (3.00 months, 95% CI 0.82–5.18 months) (p<0.001) and also in those patients with severe bulbar dysfunction (13.00 months (95% CI 9.49–16.50 months)versus3.00 months (95% CI 0.85–5.15 months), p<0.001). Prognostic factors for ALS using NIV, adjusted for NIV failure, were severity of bulbar dysfunction (hazard ratio (HR) 0.5, 95% CI 0.92–0.97; p=0.001) and time spent with oxygen saturation measured by pulse oximetry <90% (%sleepSpO2<90) using NIV (HR 1.12, 95% CI 1.01–1.24; p=0.02).

Severe bulbar impairment in ALS does not always prevent NIV from being used, but the severity of bulbar dysfunction at NIV initiation and %sleepSpO2<90 while using NIV appear to be the main prognostic factors of NIV failure in ALS.
Near-surface velocity estimation using source-domain full traveltime inversion and early arrival waveform inversion
Authors: Liu Lu , Wu Yan , Guo Bowen , Han Song , Luo Yi
Published: April 2018

Accurate estimation of near-surface velocity is a key step for imaging deeper targets. We have developed a new workflow to invert complex early arrivals in land seismic data for near-surface velocities. This workflow is composed of two methods: source-domain full traveltime inversion (FTI) and early arrival waveform inversion (EWI). Source-domain FTI automatically generates the background velocity that kinematically matches the reconstructed plane-wave sources from early arrivals with true plane-wave sources. This method does not require picking first arrivals for inversion, which is one of the most challenging and labor-intensive steps in ray-based first-arrival traveltime tomography, especially when the subsurface medium contains low-velocity zones that cause shingled multivalue arrivals. Moreover, unlike the conventional Born-based method, source-domain FTI can determine if the initial velocity is slower or faster than the true one according to the gradient sign. In addition, the computational cost is reduced considerably by using the one-way wave equation to extrapolate the plane-wave Green’s function. The source-domain FTI tomogram is then used as the starting model for EWI to obtain the short-wavelength component associated with the velocity model. We tested the workflow on two synthetic and one onshore filed data sets. The results demonstrate that source-domain FTI generates reasonable background velocities for EWI even though the first arrivals are shingled, and that this workflow can produce a high-resolution near-surface velocity model.
Fank1 and Jazf1 promote multiciliated cell differentiation in the mouse airway epithelium
Authors: Johnson Jo-Anne , Watson Julie K. , Nikolić Marko Z. , Rawlins Emma L.
Published: April 2018

The airways are lined by secretory and multiciliated cells which function together to remove particles and debris from the respiratory tract. The transcriptome of multiciliated cells has been extensively studied, but the function of many of the genes identified is unknown. We have established an assay to test the ability of over-expressed transcripts to promote multiciliated cell differentiation in mouse embryonic tracheal explants. Overexpression data indicated that Fibronectin type 3 and ankyrin repeat domains 1 (Fank1) and JAZF zinc finger 1 (Jazf1) promoted multiciliated cell differentiation alone, and cooperatively with the canonical multiciliated cell transcription factor Foxj1. Moreover, knock-down of Fank1 or Jazf1 in adult mouse airway epithelial cultures demonstrated that these factors are both required for ciliated cell differentiation in vitro. This analysis identifies Fank1 and Jazf1 as novel regulators of multiciliated cell differentiation. Moreover, we show that they are likely to function downstream of IL6 signalling and upstream of Foxj1 activity in the process of ciliated cell differentiation. In addition, our in vitro explant assay provides a convenient method for preliminary investigation of over-expression phenotypes in the developing mouse airways.

This article has an associated First Person interview with the first author of the paper.
Nieokreśloność a kwantyfikacja: współdziałanie kategorii semantycznych
Authors: Kiklewicz Aleksander
Published: April 2018

Indefiniteness and Quantification: Cooperation of Semantic CategoriesThe author considers the relationship between the category of quantification and the category of definiteness/ indefiniteness. In the reference theory, which prevailed in linguistics in the 1980s and 1990s, these two categories were considered in the light of integration, i.e. as varieties of a single semantic function. Therefore, quantifiers were regarded as exponents of the referential function of nominal groups, and considered together with such entities as determiners, articles, demonstrative pronouns, indefinite pronouns, and others. The author shows that this concept is wrong. True, semantic categories interact with one another but each of them has its own functional identity. The author treats quantifiers as one of three types of quantitative determination of nominal groups, and also shows the completion of quantification semantics in expressions with indefinite pronouns, as well as the completion of indefiniteness in expressions with quantifiers.
Charakterystyka wzajemnych powiązań tekstu z dyskursem
Authors: Płowens Jakub
Published: April 2018

An Explanation of Interconnections Between Text and DiscourseThe paper aims to explain the interconnections between text and discourse. It presents some views on discourse and text, and concludes that discourse has the superior and multicodal character in relation to text. An assumption is made that text has a dual nature; it is a product of language, and part of communication. Moreover, the author makes an attempt to describe the role of context as a kind of mechanism which links the level of text with the area of discourse, thus rendering the text comprehensible. In addition, the paper emphasizes the cognitive processes involved in the comprehension of text through context.
Automat do odmiany i składania liczebników głównych, czyli o pewnej aplikacji internetowej
Authors: Bronk Zbigniew
Published: April 2018

An Automaton for Declining and Combining of Cardinal Numerals, or About a Certain Internet ApplicationThe paper describes the workings of a website which main purpose is to serve as a didactic aid in the teaching of the grammar of Polish numerals. The user inputs a natural number into the application (as a string of digits), and selects the categories of gender and case; the output is the declined number as a word, together with the syntactic requirements of the numeral group which corresponds to the given number. The paper presents the theoretical basis of the algorithm of this application, and some problems and doubts which arose during its implementation.
Ewolucja zakresu pojęciowego niesufiksalnych technik słowotwórczych
Authors: Jadacka Hanna
Published: April 2018

The Evolution of Suffixless Techniques of Word-FormationThe goal of the paper is to remind the reader about paradigmatic derivation, clipping and derivation by exchange of prefixes, three recently recognized and defined techniques of word-formation. The author points out that, thanks to more than a dozen detailed studies and three important monographs, the description of the Polish system of word-formation gained in simplicity and distinctness, thus also benefitting academic didactics. Introducing the distinction between paradigmatic derivation and clipping proved particularly advantageous. The fate of derivation by exchange of affixes, which we are now forced to reduce to derivation by exchange of prefixes, proved to be both interesting and surprising. The paper emphasizes the input of Professor Bogusław Kreja as a contributor or inspirer of every one of the research areas mentioned above. We can only regret that he never voiced his opinion about the so-called derivation by alternation, a problem which still requires a deeper analysis.
Tekstowe funkcje dwukropka – na przykładzie "Dziejów w Koronie Polskiej" Łukasza Górnickiego
Authors: Tutak Kinga
Published: April 2018

Textual Functions of the Colon: Using the Example of Łukasz Górnicki’s Dzieje w Koronie PolskiejThe paper analyses the textual functions of the colon in 1637–1855 editions of Łukasz Górnicki’s Dzieje w Koronie Polskiej. The colon, as an element of rhetoric-intonational punctuation, served to organize and to adequately manage the textual matter. In 19th c. editions of Dzieje…, we observe a snuffing out of textual functions of the colon, in connection with the transition to the syntactic-logical punctuation.
Ślady dawnych gwar typu bułgarskiego w północno-wschodnich Węgrzech
Authors: Zoltán András
Published: April 2018

Traces of Old Bulgarian Dialects in North-Eastern HungaryThe paper presents the oldest Slavic borrowings in Hungarian together with a reconstruction of the Slavic dialectal landscape of the Carpathian Basin at the time when Hungarian tribes arrived there at the end of the 9th century. According to some phonetic criteria, it seems that Hungarians found two main Slavic dialects in their new homeland: Pannonian Slavic with mixed West and South Slavic features, and Bulgarian Slavic. The dialects of the Bulgarian type might be attributed to today’s north- -eastern Hungary and the neighboring districts of Slovakia.
Wyrazy z formantem -acja w gwarach polskich na tle historycznojęzykowym
Authors: Reichan Jerzy
Published: April 2018

Words with the -acja Formant in Polish Dialects, Against the Background of Historical Linguistic DataPolish dialectal words with the -acja formant can be divided into two groups: 1) words with Latin roots borrowed directly from Latin or through the mediation of West European languages, e.g. administracja < administrować (Lat. administratio < administrare); mobilizacja < mobilizować (French mobilisation < mobiliser, German Mobilisation < mobilisieren; Lat. mobilis); 2) words with Slavic or German roots (in words borrowed from German), e.g. marnacja < marnować (the Slavic root marn); pielęgnacja < pielęgnować (the German word pflegen). The present article describes both groups. A more detailed description of the second group is presented in a separate paper (Reichan 2012).
Kategoria stylu w badaniach metaleksykograficznych
Authors: Rudnicka Ewa
Published: April 2018

The Category of Style in Metalexicographic ResearchThe paper discusses the category of style and the validity of its application to dictionaries. The author begins by considering the question of textuality of dictionaries and whether it is possible to analyse them in line with other texts. By invoking concrete examples, she indicates works which use diverse means of expression to convey the same content, which suggests that the category of style may also be applied in the field of lexicography. The author attempts to determine what it would involve to identify style in a dictionary, which components of style may come into play here, and examines the possibilities of observation and interpretation of selected components. Finally, the paper discusses the usefulness of automatized stylometric tools in stylistic research into dictionaries.
Czasownikowe wykładniki nakłaniania kogoś do czegoś z perspektywy semantycznej. Rekonesans badawczy
Authors: Wołoszyn Joanna
Published: April 2018

Verbal Indicators of Inducing Someone to Do Something from the Semantic Perspective. Research ReconnaissanceThe goal of this paper is to perform a preliminary investigation of the notion of inducing someone to do something. The first part of the text presents the state of research into indicators of inducing someone to do something, while the second is an attempt to compile a list of expressions which represent the notion in question.
Nad kartami prac Profesora Witolda Mańczaka. Notatki z marginesów
Authors: Chlebda Wojciech
Published: April 2018

Studying the Works of Professor Witold Mańczak. Marginal NotesIn the works written in the last period of his life, Professor Witold Mańczak often emphasized the need to formulate a criterion of truth in linguistics. He pursued it in textual reality (in “what is written and what is said”) and in statistical, frequentative and quantitative data which describe it. On the margin of this search, this author shares his own experiences in the field of ethnolinguistics, related to attempts to determine the actual (and, in this sense, true) ontological status of analyzed objects. He postulates that the diversification of the objects of analysis should be complemented by an adequate diversification of how their names are recorded in the narration, i.e. by a precise and consistent descriptive metalanguage.
Surveillance imaging for sporadic renal angiomyolipoma less than 40 mm: lessons learnt and recommendations from the experience of a large district general hospital
Authors: Chan KE , Chedgy ECP , Bent CL , Turner KJ
Published: April 2018

Introduction

Sporadic renal angiomyolipomas, although benign in natural can cause life-threatening spontaneous haemorrhage. Surveillance of smaller lesions is recommended but there is no guidance on the surveillance interval or modality. Our aim was to study our sporadic angiomyolipoma population to determine the growth rate, factors that were associated with a higher growth rate and design a surveillance programme.

Materials and methods

All sporadic renal angiomyolipomas diagnosed between September 2009 and March 2015 were included. Patients with a diagnosis of tuberous sclerosis were excluded.

Results

A total of 217 sporadic renal angiomyolipomas were diagnosed. The median follow-up was 24 months (range 10–118 months). The median size at diagnosis was 9.00 mm with a mean growth rate of 0.13 mm/year (standard deviation 0.88). One hundred and fifty angiomyolipomas (69%) were shown to have negative or zero growth. In the remaining 67, 59 had a growth rate of less than 2.00 mm/year. Size of angiomyolipoma, tumour burden and age were not associated with a higher growth rate on multivariate analysis.

Conclusion

The majority of sporadic angiomyolipomas are small and do not grow. Our practice is to perform surveillance for those greater than 20 mm, with five-yearly ultrasound scans for 21–29 mm, and two-yearly surveillance for 30–39 mm tumours.
Nodular fasciitis involving the palm
Authors: Emori M , Shimizu J , Murahashi Y , Mizushima E , Sugita S , Hasegawa T , Yamashita T
Published: April 2018

Nodular fasciitis (NF) is a self-limiting fibrous neoplasm that can be mistaken for a soft tissue sarcoma. It is characterised by rapid growth, slight pain and local tenderness. Although it is frequently found in the forearm, a lesion distal to the wrist is quite rare. We present two unusual cases of NF involving the palm, supported by detecting ubiquitin specific protease 6 gene rearrangement. The first patient had non-intraneural NF presenting as peripheral neuropathy affecting the digital nerve while the second patient suffered from painless, non-tender NF in the palm, which had not regressed spontaneously during the five months prior to surgery.
Calcific myonecrosis: diagnostic dilemma
Authors: Matar HE , Stritch P , Connolly S , Emms N
Published: April 2018

Calcific myonecrosis is a rare benign condition affecting mainly the muscles of a single leg compartment. It is thought to follow a history of trauma with a latent period of years. Patients present with a slowly growing mass. Differential diagnosis from a malignant tumour can be made from the history and the distinctive radiographical features of a fusiform lesion with predominantly peripheral calcifications. Magnetic resonance imaging may be necessary to confirm the diagnosis; treatment is largely symptomatic.
Omega-3 gantz azidoak eta osasuna
Authors: Kajarabille Naroa , Fernández-Quintela Alfredo , Portillo Maria Puy
Published: April 2018

Kate luzeko omega-3 gantz-azido poliasegabeak, azido eikosapentaenoikoa (EPA) eta azido dokosahexaenoikoa (DHA) kasurako, kantitate handitan aurkitzen dira arrain koipetsuetan eta haietatik eratorritako arrain-olioan, zeina elikadura-osagarri gisa erabiltzen den (nutrazeutiko gisa, alegia). EPA zein DHA mintz zelularren fosfolipidoei gehitzen zaizkio, non lipooxigenasa eta ziklooxigenasa entzimen bidez jaria dai- tezkeen, eta zelula babesten duten hanturen kontrako produktuak eratu. Hainbat ikerketaren arabera, EPA eta DHA kontsumitzea baliagarria da zenbait gaixotasun ekiditeko edota haien tratamendurako, hantura-prozesuak eragindako gaixotasunetan bereziki. Hain zuzen ere, EPA eta DHAk hanturaren kontrako propietateak dituzte, bai erresolbina gisako hanturaren kontrako eragileak ekoiztuz, edota hantura eragileak blokeatuz. Ebidentzia zientifiko honen arabera, kate luzeko omega-3 gantz-azidoek zenbait aplikazio izan patologia kliniko edo nutrizional ezberdinen tratamenduan nahiz edota prebentzioan. Alabaina, gaur egun gantz-azido aseen kontsumoa zeharo hazi da, eta lipido onuragarrien kontsumoa, berriz, jaitsi egin da; era honetan, populazioaren atal handi batek omega-3 gantz-azidoen gabezia aurkezten du. Frogatu da egoera honek eragin handia duela endekapenezko gaixotasunen garapenean esaterako, gaixotasun kardiobaskularrak, minbizia, hantura-prozesuak eta bereziki ikusmenaren eta nerbio sistema zentralaren osasunean eta garapenean, non DHA kontzentrazio handiak dauden.
Entzefalopatia hipoxiko-iskemikoaren eragina arratoien entzunbidean
Authors: Revuelta Miren , Álvarez Antonia de los Ángeles , Hilario Enrique
Published: April 2018

Entzunbidearen garapena nerbio sistema zentralaren mielinizazioaren menpe dago, eta entzefalopatia hipoxiko-iskemikoak eta antzeko gaitzek kalte egin diezaiokete. Gure helburua izan da entzunbidearen funtzio egokia ebaluatzea eta metodo histologiko eta molekularren bitartez kaltea aztertzea, 7 eguneko Sprague Dawley arratoiak erabiliz. Gure emaitzek hipoxia iskemiko baten ostean entzunbidea kaltetzen dela baieztatzen dute; izan ere, elektrofisiologikoki estimulu baten erantzuna atzeratzen da kaltearen ostean, astrozitoen erreaktibitate handiagoa dago animalia kaltetuen kasuan, eta mielina galera gertatzen da animalia horietan.
Behi-haragiaren samurtasuna aztergai: estrategia proteomiko berri baten garapena
Authors: R. Beldarrain Lorea , Aldai Noelia , Sentandreu Miguel Angel
Published: April 2018

Samurtasuna behi-haragiaren kalitatean eragiten duen ezaugarri garrantzitsua da, kontsumitzaileak produktua aukeratzeko orduan gehien balioesten duenen artean dagoena. Hori dela eta, muskulua haragi bihurtu bitarteko prozesu biokimikoaren azterketak berebiziko garrantzia dauka. Izan ere, ontze-prozesu honetan garatzen da neurri handi batean amaierako produktuaren samurtasuna. Prozesu honetan proteinek daukaten garrantzizko papera laburbilduko da artikulu honetan, bai eta teknika proteomikoek haragiaren kalitatea aztertzeko eta optimizatzeko eskaintzen dituzten aukerak ere, haragi-industriari begira probetxuzkoak izan daitezkeenak. Zentzu honetan, gure taldeak garatutako estrategia proteomiko berria aurkeztuko da, isoelektrofokatze likidoa (OFFGEL) eta elektroforesia oinarri dituena. Maine Anjou behi arrazako animalien haragian burututako esperimentuan samurtasunaren adierazgarri diren 7 banda identifikatu eta neurtu dira, muskuluaren proteoma ikertzeko metodologia berritzaile honen potentziala agerian utziz.
PARECERISTAS (Ad hoc) 2016
Authors: Nuances Editor
Published: April 2018

A revista Nuances: estudos sobre Educação agradece aos membros PARECERISTAS que atuaram como avaliadores externos (ad hoc) nas Edições do ano de 2016. Nossos sinceros agradecimentos.
FORMAÇÃO DE EDUCADORES DO PEJA: AÇÃO COLETIVA, REFLEXÃO CONTEXTUALIZADA E PROJETOS DE TRABALHO
Authors: Girotto Cyntia G.G. Simões , Miguel José Carlos , Miller Stela
Published: April 2018

O presente artigo tem como objetivo evidenciar uma das possibilidades de formação dos profissionais de EJA (Educação de Jovens e Adultos), qual seja, a formação contínua, que acompanha a trajetória de trabalho do educador com seus alunos, tendo como suporte sua inserção em projeto de pesquisa, na perspectiva de um processo coletivo que envolve ação-reflexão-ação. Objetiva, também, pôr em discussão as  bases sobre as quais podem ser construídas as aprendizagens na área de matemática, leitura e escrita.
EDUCAÇÃO E INFÂNCIA: ENSAIO SOBRE PODER E CONTROLE
Authors: Mesomo Aliandra Cristina
Published: April 2018

Este texto pretende problematizar questões voltadas à educação no momento atual, procurando  refletir sobre as práticas educacionais institucionais a partir de situações de poder nelas verificadas. Para tanto, toma os estudos de Michel Foucault sobre a dominação dos corpos, tempos e espaços nas instituições (entre elas a escola) como referencial teórico elementar para a fundamentação das problematizações. A faixa etária escolar sobre a qual serão feitas as considerações e reflexões educacionais refere-se às crianças de 0 a 6 anos, ou seja, a Educação Infantil. No entanto, muitas das considerações podem ser estendidas e entendidas no contexto escolar mais amplo.
AVALIAR E APRENDER COM TEXTOS PRODUZIDOS PELOS ALUNOS
Authors: Belão Vânia Kelen , Menin Ana Maria da Costa Santos
Published: April 2018

Considerando o papel da avaliação, particularmente, no que diz respeito à produção de textos, buscamos repensar a prática avaliativa, a partir de novas perspectivas que vêm sendo apontadas tanto por estudiosos da avaliação quanto por aqueles que discutem o ensino de língua portuguesa, privilegiando a construção do conhecimento e a aprendizagem significativa do aluno, ao se apropriar do código lingüístico escrito. Entendemos que a natureza da avaliação não concebe relacioná-la a instrumentos de medida de resultados com fim último de aprovar ou reprovar. Avaliar refere-se a um processo de acompanhamento do desenvolvimento do educando, que implica uma regulação feita pelo professor e pelo aluno, objetivando melhorar o ensino-aprendizagem. Neste processo, o texto produzido pode ser um aliado, pois é uma forma de expressão do aluno, podendo fornecer informações que auxiliem a análise e interpretação das aprendizagens, contribuindo assim, para a realização das remediações necessárias.
A EXPERIÊNCIA DOS IUFM NA FRANÇA (1991-2004). BALANÇO SÓCIO HISTÓRICO E PERSPECTIVAS
Authors: Robert André
Published: April 2018

No fim dos anos 1980, foram criados na França institutos de formação de professores (IUFM). Projecto extremamente criticado, estes institutos tiveram grande dificuldade em se fazerem identificar, num contexto de crise intensa de recrutamento de docentes em que as Escolas Normais mantinham, aos olhos do público em geral e ao longo do tempo, o monopólio mítico da formação dos professores para o ensino primário. Quinze anos depois, parece-nos justificável um balanço histórico, sociológico e pedagógico desses institutos, num momento em que se considera uma nova reforma dos IUFM: o que realmente deve ser um "professor" hoje? Ou ainda, como conceber o professor "eficaz" num contexto educacional caracterizado por uma crise de paradigmas que torna mais difícil um consenso sobre a definição da profissionalidade docente? Em consequência disto, que conteúdo deve ser dado à formação, para que ela responda ao mesmo tempo a este objectivo e para que crie menos insatisfação nos próprios formados?
APRESENTAÇÃO
Authors: Nuances Revista
Published: April 2018

APRESENTAÇÃO
A LITERATURA EM SALA DE AULA: NOVAS CONCEPÇÕES DE ABORDAGEM DO TEXTO EM PROSA
Authors: Boberg Hiudéa Tempesta Rofrigues
Published: April 2018

Este artigo tem o objetivo de apresentar a professores e demais interessados, uma proposta de abordagem de textos literários em prosa, para as 7ª e 8ª séries do Ensino Fundamental, através da aplicação das etapas do Método Recepcional associadas às concepções de transversalidade e de transdisciplinaridade.
“HISTÓRIAS COM PROBLEMAS” UMA FORMA DE EDUCAR PARA A NUMERACIA E PARA A LITERACIA
Authors: Sardinha Maria de Fátima Morais , Azevedo Fernando José de Fraga , Palhares Pedro Manuel Baptista
Published: April 2018

As “histórias com problemas” são uma estratégia de ensino que visa, através de uma abordagem interdisciplinar, ligar a Língua Portuguesa à Matemática. Este artigo analisa parte de um estudo realizado no âmbito de uma investigação de mestrado numa turma do 3.º ano do 1.º Ciclo do Ensino Básico, em Portugal, no ano  lectivo de 2002/03. Pretendeu-se, através da implementação deste método de ensino, analisar se as histórias com problemas promoviam uma educação para a literacia e para a numeracia. São aqui analisados os dados recolhidos através de observação, acompanhada de gravação vídeo, numa situação em que os alunos, após resolverem um problema matemático não rotineiro, tinham que criar uma história para melhor contextualizar o problema. A partir desta análise são apresentadas as conclusões e reflexões sobre a eficácia deste método no desenvolvimento de competências de numeracia e literacia.
VAMOS À BIBLIOTECA! - O PAPEL DA BIBLIOTECA ESCOLAR NA FORMAÇÃO DE CRIANÇAS LEITORAS
Authors: Balça Ângela Coelho de Paiva
Published: April 2018

Uma das instituições que contribui para a formação de crianças leitoras é a biblioteca escolar. Neste artigo, tentamos perceber a importância e o papel desempenhado por esta instituição, na formação de crianças leitoras, em vários níveis de ensino. Deste modo, começamos pela dinamização quer da área da leitura e da escrita quer da biblioteca, no contexto da educação pré-escolar. Centramos igualmente a nossa atenção no contexto do ensino básico, em Portugal, com a dinamização da biblioteca de turma e da biblioteca da escola. Por último, lançamos ainda um olhar sobre as atitudes dos professores em relação à biblioteca da escola e sobre as práticas de frequência desta pelos alunos.
LIVRO DE IMAGEM: POSSIBILIDADES DE LEITURA ESTÉTICA
Authors: Mathias Tânia Sayuri Ida
Published: April 2018

LIVRO DE IMAGEM: POSSIBILIDADES DE LEITURA ESTÉTICA
AVALIAÇÃO DE CONTEXTOS NA PERSPECTIVA DA PEDAGOGIA DA INFÂNCIA: INDICAÇÕES PARA A INVESTIGAÇÃO A PARTIR DOS PROTAGONISTAS
Authors: Rocha Eloísa Acires Candal , Filho João Josué da Silva
Published: April 2018

O trabalho que aqui apresentamos sintetiza parte do processo de reflexão que temos desenvolvido junto ao Núcleo de Estudos e Pesquisas da Educação na Pequena Infância NUPEIN – no Centro de Ciências da Educação da UFSC. Os resultados apontam para a importância do processo de valorização do profissional responsável pela organização e pela ação educativa, implicando necessariamente no esforço de engajamento dos mesmos no processo de reflexão sobre sua própria prática e formação. Nessa perspectiva, temos clareza que as pesquisas realizadas nas instituições só fazem sentido na medida em que de fato possam contribuir para a melhoria do trabalho realizado junto às meninas e meninos que freqüentam creches e pré-escolas. O estabelecimento de indicadores para avaliação dos contextos educativos exige de um lado, maior articulação entre os processos de investigação e os de formação e, de outro lado, uma compreensão do que se entende por avaliação.
PROPOSTAS DE CUIDADO E EDUCAÇÃO NO AMBIENTE DA CRECHE – ASPECTOS HISTÓRICOS E FORMAÇÃO DE PROFESSORES
Authors: Spada Ana Corina Machado
Published: April 2018

O presente artigo discute a educação desenvolvida no interior das creches, tomando como referência o cenário brasileiro. Discute-se que a estruturação da rotina de atividades da creche necessita pautar-se em um modelo que não privilegie o cuidado em detrimento da educação. Contudo, a educação historicamente desenvolvida no ambiente da creche privilegiou aspectos integralmente ligados ao cuidado físico e nem sempre tais práticas são facilmente superadas no cotidiano da instituição. A formação de professores bem como o conhecimento e a reflexão acerca de tais questões, além da elaboração de um projeto educacional que norteie as ações de professores e demais profissionais no ambiente da creche são aqui discutidos como elementos capazes de favorecer a superação de problemas.
UTOPIA RIMA COM MUDANÇA TODO DIA: TEORIA E PRÁTICAS EM CRECHE
Authors: Redondo Analu Menzani , Fahl Maria Augusta , Nascimento Maria do Carmo Garcia , Souza Rosana Maria Donato Xavier de , Mello Suely Amaral
Published: April 2018

Esse artigo discute o processo de construção de um projeto pedagógico em uma creche da rede pública a partir do referencial teórico que fundamentou esse processo e as práticas adotadas a partir de então. Escrito a várias mãos, é síntese de três pontos de vista diferentes – o da assessoria pedagógica que orientou o processo no seu conjunto, o de duas professoras e o de duas pajens, responsáveis por uma mesma turma de crianças de 3 anos. Nesse sentido discute as novas concepções que envolvem a educação das crianças pequenas a partir das contribuições da teoria histórico-cultural e de pesquisas e estudos recentes realizados com crianças de 0 a 6 anos educadas em espaços coletivos nas instituições dedicadas à infância, procurando focalizar especificamente o processo de construção de conhecimento pelas crianças. Por outro lado, apresenta as mediações que concretizaram a teoria sendo apropriada pelas profissionais em processo de formação continuada. Com isso, ensaia uma avaliação da fundamentação teórica e das práticas de formação adotadas como instrumento do pensar e agir docentes. Contribui, nesse sentido, para uma reflexão acerca das necessidades de formação das profissionais da educação infantil na perspectiva de buscar garantir às crianças o direito de viverem sua infância na escola infantil, ao mesmo tempo em que se formam como sujeitos inteligentes e solidários.
INTENCIONALIDADE DA AÇÃO EDUCATIVA NA EDUCAÇAO INFANTIL: A IMPORTÂNCIA DA ORGANIZAÇÃO DO TEMPO E DO ESPAÇO DAS ATIVIDADES
Authors: Rodrigues Sílvia Adriana , Garms Gilza Maria Zauhy
Published: April 2018

Ao refletir sobre a intencionalidade de toda ação educativa praticada por professores em situações planejadas de ensino aprendizagem, uma pergunta interpõe-se entre as inquietações dos educadores: como organizar tempo, espaço e procedimentos didáticos que possam, efetivamente, favorecer o processo de ensino-aprendizagem das crianças pequenas? Esta é a questão norteadora do presente texto, que elegeu como propósito analisar as propostas de “rotinas” orientadoras do trabalho na educação infantil que foram levantadas no estudo realizado junto aos professores-alunos matriculados no Projeto Pedagogia Cidadã – Pólo de Presidente Prudente, que atuavam na educação infantil (tanto como professores, quanto como auxiliares de desenvolvimento infantil – ADI). Os dados obtidos apontam a abrangência das propostas consideradas essenciais para o trabalho junto à criança pequena no que diz respeito à organização do tempo e do trabalho pedagógico; mas também para uma distorção dos objetivos primordiais da educação infantil. Cabe salientar que este trabalho é substrato de pesquisa realizada nos anos de 2004 e 2005, que teve como objetivo central descrever e analisar a formação em serviço do profissional de educação infantil no citado projeto.
FAMÍLIA-ESCOLA: UMA RELAÇÃO POSSÍVEL
Authors: Maimone Eulália Henriques , De Oliveira Maria Olivia Borges , Vieira Giovanna Mara Sá , De Pieri Maria Guilhermina Coelho
Published: April 2018

Uma das dimensões da qualidade na Educação Infantil é a relação família-escola. A partir de um diagnóstico de uma instituição de educação infantil da periferia de uma cidade do interior de Minas Gerais, em que se constatou a necessidade de serem melhoradas as estratégias de participação de pais, foi proposto o presente trabalho. Este teve como objetivo aumentar essa participação, propiciando aos professores oportunidade de formação. Para atingir esse objetivo, foram planejadas e executadas ações conjuntas com a participação de pais, mães, avós, crianças e professoras, que consistiram em dinâmicas de grupo pela técnica do brincar junto. Houve dinâmicas iniciais, que possibilitaram momentos de apropriação dessa forma de trabalho pelo pessoal da creche e dinâmicas realizadas por sala de 3, 4 e 5 anos, planejadas e desenvolvidas pelas educadoras, sendo videogravadas. As avaliações indicaram um caminho promissor para uma mudança nas reuniões de pais e nas concepções sobre o brincar.
A EDUCAÇÃO INFANTIL NO CONTEXTO DA CRECHE: UM ESTUDO SOBRE A EDUCAÇÃO, O CUIDADO DA CRIANÇA DE ZERO A TRÊS ANOS E A FORMAÇÃO DE PROFESSORES NO MUNICÍPIO DE MARÍLIA – SP
Authors: Spada Ana Corina Machado
Published: April 2018

A EDUCAÇÃO INFANTIL NO CONTEXTO DA CRECHE: UM ESTUDOSOBRE A EDUCAÇÃO, O CUIDADO DA CRIANÇA DE ZERO A TRÊSANOS E A FORMAÇÃO DE PROFESSORES NO MUNICÍPIO DEMARÍLIA – SP