bluuebunny/crossref_metadata_2025 huggingface dataset:
Genomic Heterogeneity of Pancreatic Ductal Adenocarcinoma and Its Clinical Impact
Authors: Gutiérrez María Laura , Muñoz-Bellvís Luis , Orfao Alberto
Published: September 2021

Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer death due to limited advances in recent years in early diagnosis and personalized therapy capable of overcoming tumor resistance to chemotherapy. In the last decades, significant advances have been achieved in the identification of recurrent genetic and molecular alterations of PDAC including those involving the KRAS, CDKN2A, SMAD4, and TP53 driver genes. Despite these common genetic traits, PDAC are highly heterogeneous tumors at both the inter- and intra-tumoral genomic level, which might contribute to distinct tumor behavior and response to therapy, with variable patient outcomes. Despite this, genetic and genomic data on PDAC has had a limited impact on the clinical management of patients. Integration of genomic data for classification of PDAC into clinically defined entities—i.e., classical vs. squamous subtypes of PDAC—leading to different treatment approaches has the potential for significantly improving patient outcomes. In this review, we summarize current knowledge about the most relevant genomic subtypes of PDAC including the impact of distinct patterns of intra-tumoral genomic heterogeneity on the classification and clinical and therapeutic management of PDAC.
Nucleic Acid Sensing in the Tumor Vasculature
Authors: Baris Adrian M. , Fraile-Bethencourt Eugenia , Anand Sudarshan
Published: September 2021

Endothelial cells form a powerful interface between tissues and immune cells. In fact, one of the underappreciated roles of endothelial cells is to orchestrate immune attention to specific sites. Tumor endothelial cells have a unique ability to dampen immune responses and thereby maintain an immunosuppressive microenvironment. Recent approaches to trigger immune responses in cancers have focused on activating nucleic acid sensors, such as cGAS-STING, in combination with immunotherapies. In this review, we present a case for targeting nucleic acid-sensing pathways within the tumor vasculature to invigorate tumor-immune responses. We introduce two specific nucleic acid sensors—the DNA sensor TREX1 and the RNA sensor RIG-I—and discuss their functional roles in the vasculature. Finally, we present perspectives on how these nucleic acid sensors in the tumor endothelium can be targeted in an antiangiogenic and immune activation context. We believe understanding the role of nucleic acid-sensing in the tumor vasculature can enhance our ability to design more effective therapies targeting the tumor microenvironment by co-opting both vascular and immune cell types.
Cannabinoids and Cancer
Authors: Falasca Marco , Maccarrone Mauro
Published: September 2021

Cannabinoids, active components of the plant Cannabis sativa, had been used for centuries in ancient medicine as therapeutic remedies for a variety of conditions, before becoming stigmatized due to their psychoactive effects [...]
Elevated Flt3L Predicts Long-Term Survival in Patients with High-Grade Gastroenteropancreatic Neuroendocrine Neoplasms
Authors: Detjen Katharina M. , Otto Raik , Giesecke Yvonne , Geisler Lukas , Riemer Pamela , Jann Henning , Grötzinger Carsten , Sers Christine , Pascher Andreas , Lüdde Tom , Leser Ulf , Wiedenmann Bertram , Sigal Michael , Tacke Frank , Roderburg Christoph , Hammerich Linda
Published: September 2021

Background: The clinical management of high-grade gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN) is challenging due to disease heterogeneity, illustrating the need for reliable biomarkers facilitating patient stratification and guiding treatment decisions. FMS-like tyrosine kinase 3 ligand (Flt3L) is emerging as a prognostic or predictive surrogate marker of host tumoral immune response and might enable the stratification of patients with otherwise comparable tumor features. Methods: We evaluated Flt3L gene expression in tumor tissue as well as circulating Flt3L levels as potential biomarkers in a cohort of 54 patients with GEP-NEN. Results: We detected a prominent induction of Flt3L gene expression in individual G2 and G3 NEN, but not in G1 neuroendocrine tumors (NET). Flt3L mRNA expression levels in tumor tissue predicted the disease-related survival of patients with highly proliferative G2 and G3 NEN more accurately than the conventional criteria of grading or NEC/NET differentiation. High level Flt3L mRNA expression was associated with the increased expression of genes related to immunogenic cell death, lymphocyte effector function and dendritic cell maturation, suggesting a less tolerogenic (more proinflammatory) phenotype of tumors with Flt3L induction. Importantly, circulating levels of Flt3L were also elevated in high grade NEN and correlated with patients’ progression-free and disease-related survival, thereby reflecting the results observed in tumor tissue. Conclusions: We propose Flt3L as a prognostic biomarker for high grade GEP-NEN, harnessing its potential as a marker of an inflammatory tumor microenvironment. Flt3L measurements in serum, which can be easily be incorporated into clinical routine, should be further evaluated to guide patient stratification and treatment decisions.
Diagnostic Performance of Kwak, EU, ACR, and Korean TIRADS as Well as ATA Guidelines for the Ultrasound Risk Stratification of Non-Autonomously Functioning Thyroid Nodules in a Region with Long History of Iodine Deficiency: A German Multicenter Trial
Authors: Seifert Philipp , Schenke Simone , Zimny Michael , Stahl Alexander , Grunert Michael , Klemenz Burkhard , Freesmeyer Martin , Kreissl Michael C. , Herrmann Ken , Görges Rainer
Published: September 2021

Germany has a long history of insufficient iodine supply and thyroid nodules occur in over 30% of the adult population, the vast majority of which are benign. Non-invasive diagnostics remain challenging, and ultrasound-based risk stratification systems are essential for selecting lesions requiring further clarification. However, no recommendation can yet be made about which system performs the best for iodine deficiency areas. In a German multicenter approach, 1211 thyroid nodules from 849 consecutive patients with cytological or histopathological results were enrolled. Scintigraphically hyperfunctioning lesions were excluded. Ultrasound features were prospectively recorded, and the resulting classifications according to five risk stratification systems were retrospectively determined. Observations determined 1022 benign and 189 malignant lesions. The diagnostic accuracies were 0.79, 0.78, 0.70, 0.82, and 0.79 for Kwak Thyroid Imaging Reporting and Data System (Kwak-TIRADS), American College of Radiology (ACR) TI-RADS, European Thyroid Association (EU)-TIRADS, Korean-TIRADS, and American Thyroid Association (ATA) Guidelines, respectively. Receiver Operating Curves revealed Areas under the Curve of 0.803, 0.795, 0.800, 0.805, and 0.801, respectively. According to the ATA Guidelines, 135 thyroid nodules (11.1%) could not be classified. Kwak-TIRADS, ACR TI-RADS, and Korean-TIRADS outperformed EU-TIRADS and ATA Guidelines and therefore can be primarily recommended for non-autonomously functioning lesions in areas with a history of iodine deficiency.
A Systematic Review of the Safety, Feasibility and Benefits of Exercise for Patients with Advanced Cancer
Authors: De Lazzari Nico , Niels Timo , Tewes Mitra , Götte Miriam
Published: September 2021

Exercise therapy is a common supportive strategy in curative cancer treatment with strong evidence regarding its positive effects on, for example, cancer-related fatigue, health- related quality of life, and physical function. In the field of advanced cancer patients, knowledge about exercise as a useful supportive strategy is missing. The aim of this systematic review was to evaluate the feasibility and safety of exercise interventions as well as its effects on lowering the symptom burden. We included randomized controlled trials and nonrandomized controlled trials with advanced cancer patients receiving any type of exercise intervention. After an extensive literature search (in accordance to PRIMSA guidelines) in PubMed, Cochrane Library, and SPORTDiscus, 14 studies including 940 participants with different cancer entities were eligible. The results indicated the safety of exercise. In total, 493 participants received exercise interventions, with nine adverse events and no severe adverse events. The median recruitment rate was 68.33%, and adherence to exercise intervention was 86%. Further research with a high-quality and larger sample size is needed to clarify the potential of exercise with advanced cancer patients. Different advanced cancer entities have distinguished symptoms, and future research should construct entities-specific trial populations to figure out the best supportive exercise interventions.
Prognostic and Therapeutic Potential of the OIP5 Network in Papillary Renal Cell Carcinoma
Authors: Chow Mathilda Jing , Gu Yan , He Lizhi , Lin Xiaozeng , Dong Ying , Mei Wenjuan , Kapoor Anil , Tang Damu
Published: September 2021

Papillary renal cell carcinoma (pRCC) is an aggressive but minor type of RCC. The current understanding and management of pRCC remain poor. We report here OIP5 being a novel oncogenic factor and possessing robust prognostic values and therapeutic potential. OIP5 upregulation is observed in pRCC. The upregulation is associated with pRCC adverse features (T1P < T2P < CIMP, Stage1 + 2 < Stage 3 < Stage 4, and N0 < N1) and effectively stratifies the fatality risk. OIP5 promotes ACHN pRCC cell proliferation and xenograft formation; the latter is correlated with network alterations related to immune regulation, metabolism, and hypoxia. A set of differentially expressed genes (DEFs) was derived from ACHN OIP5 xenografts and primary pRCCs (n = 282) contingent to OIP5 upregulation; both DEG sets share 66 overlap genes. Overlap66 effectively predicts overall survival (p < 2 × 10−16) and relapse (p < 2 × 10−16) possibilities. High-risk tumors stratified by Overlap66 risk score possess an immune suppressive environment, evident by elevations in Treg cells and PD1 in CD8 T cells. Upregulation of PLK1 occurs in both xenografts and primary pRCC tumors with OIP5 elevations. PLK1 displays a synthetic lethality relationship with OIP5. PLK1 inhibitor BI2356 inhibits the growth of xenografts formed by ACHN OIP5 cells. Collectively, the OIP5 network can be explored for personalized therapies in management of pRCC patients.
MYC Rules: Leading Glutamine Metabolism toward a Distinct Cancer Cell Phenotype
Authors: Tambay Vincent , Raymond Valérie-Ann , Bilodeau Marc
Published: September 2021

Metabolic reprogramming and deregulated cellular energetics are hallmarks of cancer. The aberrant metabolism of cancer cells is thought to be the product of differential oncogene activation and tumor suppressor gene inactivation. MYC is one of the most important oncogenic drivers, its activation being reported in a variety of cancer types and sub-types, among which are the most prevalent and aggressive of all malignancies. This review aims to offer a comprehensive overview and highlight the importance of the c-Myc transcription factor on the regulation of metabolic pathways, in particular that of glutamine and glutaminolysis. Glutamine can be extensively metabolized into a variety of substrates and be integrated in a complex metabolic network inside the cell, from energy metabolism to nucleotide and non-essential amino acid synthesis. Together, understanding metabolic reprogramming and its underlying genetic makeup, such as MYC activation, allows for a better understanding of the cancer cell phenotype and thus of the potential vulnerabilities of cancers from a metabolic standpoint.
Additive Manufacturing as a Means of Gas Sensor Development for Battery Health Monitoring
Authors: Lupan Oleg , Krüger Helge , Siebert Leonard , Ababii Nicolai , Kohlmann Niklas , Buzdugan Artur , Bodduluri Mani Teja , Magariu Nicolae , Terasa Maik-Ivo , Strunskus Thomas , Kienle Lorenz , Adelung Rainer , Hansen Sandra
Published: September 2021

Lithium-ion batteries (LIBs) still need continuous safety monitoring based on their intrinsic properties, as well as due to the increase in their sizes and device requirements. The main causes of fires and explosions in LIBs are heat leakage and the presence of highly inflammable components. Therefore, it is necessary to improve the safety of the batteries by preventing the generation of these gases and/or their early detection with sensors. The improvement of such safety sensors requires new approaches in their manufacturing. There is a growing role for research of nanostructured sensor’s durability in the field of ionizing radiation that also can induce structural changes in the LIB’s component materials, thus contributing to the elucidation of fundamental physicochemical processes; catalytic reactions or inhibitions of the chemical reactions on which the work of the sensors is based. A current method widely used in various fields, Direct Ink Writing (DIW), has been used to manufacture heterostructures of Al2O3/CuO and CuO:Fe2O3, followed by an additional ALD and thermal annealing step. The detection properties of these 3D-DIW printed heterostructures showed responses to 1,3-dioxolan (DOL), 1,2-dimethoxyethane (DME) vapors, as well as to typically used LIB electrolytes containing LiTFSI and LiNO3 salts in a mixture of DOL:DME, as well also to LiPF6 salts in a mixture of ethylene carbonate (EC) and dimethyl carbonate (DMC) at operating temperatures of 200 °C–350 °C with relatively high responses. The combination of the possibility to detect electrolyte vapors used in LIBs and size control by the 3D-DIW printing method makes these heterostructures extremely attractive in controlling the safety of batteries.
Preparation of Silver Antibacterial Agents with Different Forms and Their Effects on the Properties of Water-Based Primer on Tilia europaea Surface
Authors: Yan Xiaoxing , Pan Pan
Published: September 2021

Micron silver particles prepared by the chemical reduction method, urea formaldehyde resin-coated nano-silver solution microcapsules, and nano-silver solution were used as three kinds of antibacterial agents. These were added to a water-based primer on the surface of Tilia europaea in contents of 1.0%, 4.0%, 7.0%, 10.0%, 13.0%, and 16.0%. In order to achieve the best comprehensive performance of the water-based primer, the mechanical, optical, and antibacterial properties of the three antibacterial coatings with different contents of silver antibacterial agents were explored. It was concluded that when the antibacterial agent content was 4.0%, the color difference, impact resistance, adhesion, and gloss of water-based primer on the Tilia europaea surface were better. When the antibacterial agent content added was 16.0%, the antibacterial properties of the three groups of coatings improved to 94.89%, 81.75%, and 83.98%, respectively. The results provide a research idea for the preparation of antibacterial coatings on the surface of wood furniture.
Risk-Stratified Pathways for Cancer Survivorship Care: Insights from a Deliberative Multi-Stakeholder Consultation
Authors: Tremblay Dominique , Touati Nassera , Bilodeau Karine , Prady Catherine , Usher Susan , Leblanc Yves
Published: September 2021

Risk-stratified pathways of survivorship care seek to optimize coordination between cancer specialists and primary care physicians based on the whole person needs of the individual. While the principle is supported by leading cancer institutions, translating knowledge to practice confronts a lack of clarity about the meaning of risk stratification, uncertainties around the expectations the model holds for different actors, and health system structures that impede communication and coordination across the care continuum. These barriers must be better understood and addressed to pave the way for future implementation. Recognizing that an innovation is more likely to be adopted when user experience is incorporated into the planning process, a deliberative consultation was held as a preliminary step to developing a pilot project of risk-stratified pathways for patients transitioning from specialized oncology teams to primary care providers. This article presents findings from the deliberative consultation that sought to understand the perspectives of cancer specialists, primary care physicians, oncology nurses, allied professionals, cancer survivors and researchers regarding the following questions: what does a risk stratified model of cancer survivorship care mean to care providers and users? What are the prerequisites for translating risk stratification into practice? What challenges are involved in establishing these prerequisites? The multi-stakeholder consultation provides empirical data to guide actions that support the development of risk-stratified pathways to coordinate survivorship care.
Radiotherapy or Surgery? Comparative, Qualitative Assessment of Online Patient Education Materials on Prostate Cancer
Authors: Vu Erwin , Pratsinis Manolis , Plasswilm Ludwig , Schmid Hans-Peter , Panje Cédric , Betschart Patrick
Published: September 2021

As multiple different treatment options are available for prostate cancer (PCa) and YouTube is commonly used as a source for medical information, we performed a systematic and comparative assessment of available videos guiding patients on their choice for the optimal treatment. An independent search for surgical therapy or radiotherapy of PCa on YouTube was performed and the 40 most viewed videos of both groups were analyzed. The validated DISCERN questionnaire and PEMAT were utilized to evaluate their quality and misinformation. The median overall quality of the videos was found to be low for surgery videos, while radiotherapy videos results reached a moderate quality. The median PEMAT understandability score was 60% (range 0–100%) for radiotherapy and 75% (range 40–100) for surgery videos. The radiotherapy videos contained less misinformation and were judged to be of higher quality. Summarized, the majority of the provided videos offer insufficient quality of content and are potentially subject to commercial bias without reports on possible conflict of interest. Thus, most of available videos on YouTube informing PCa patients about possible treatment methods are not suited for a balanced patient education or as a basis for the patient’s decision.
The Problem of Fairness in Synthetic Healthcare Data
Authors: Bhanot Karan , Qi Miao , Erickson John S. , Guyon Isabelle , Bennett Kristin P.
Published: September 2021

Access to healthcare data such as electronic health records (EHR) is often restricted by laws established to protect patient privacy. These restrictions hinder the reproducibility of existing results based on private healthcare data and also limit new research. Synthetically-generated healthcare data solve this problem by preserving privacy and enabling researchers and policymakers to drive decisions and methods based on realistic data. Healthcare data can include information about multiple in- and out- patient visits of patients, making it a time-series dataset which is often influenced by protected attributes like age, gender, race etc. The COVID-19 pandemic has exacerbated health inequities, with certain subgroups experiencing poorer outcomes and less access to healthcare. To combat these inequities, synthetic data must “fairly” represent diverse minority subgroups such that the conclusions drawn on synthetic data are correct and the results can be generalized to real data. In this article, we develop two fairness metrics for synthetic data, and analyze all subgroups defined by protected attributes to analyze the bias in three published synthetic research datasets. These covariate-level disparity metrics revealed that synthetic data may not be representative at the univariate and multivariate subgroup-levels and thus, fairness should be addressed when developing data generation methods. We discuss the need for measuring fairness in synthetic healthcare data to enable the development of robust machine learning models to create more equitable synthetic healthcare datasets.
Temperature Measurement—Inquiry-Based Learning Activities for Third Graders
Authors: Gerhátová Žaneta , Perichta Peter , Drienovský Marián , Palcut Marián
Published: September 2021

The article presents our Inquiry-Based Learning (IBL) activities in the project-based Science education of third graders (8–9-year-old pupils) in the Slovak Republic. Individual tasks of project assignment titled “Temperature Measurement” were conceived for “guided inquiry”. We also supported the IBL of pupils by interactive education strategy–Integrated e-Learning (INTe-L). The strategy was built on the role of interactive simulations and experimenting at the knowledge acquisition. The following INTe-L components were used: (a) on-site and remote experiments, (b) interactive simulations and (c) electronic study materials. The research was based the hypothesis that the project-based teaching of the topic “Temperature Measurement” using the IBL activities is significantly more efficient than traditional (instructivist) way of teaching. To verify the hypothesis, we carried out a pedagogical experiment on a sample of 60 respondents. The third graders were divided into two parallel groups: an experimental group (EG, 30 pupils) and control group (CG, 30 pupils). To get a relevant feedback, pre-test and post-test were developed and applied. The results attained in the EG were statistically processed, evaluated, and subsequently compared with those in the CG. The analysis of the results attained by the EG showed that their knowledge acquisition has been increased by 24% compared to CG. We have created a methodology for making simple scientific project assignments with the implementation of all components of the new integrated e-learning education strategy (real and real remote experiment, e-simulation, e-learning material). On a specific example of the topic “Temperature Measurement” in primary education, we have presented the possibility of using a “guided inquiry” in the implementation of individual experimental tasks. We have introduced a form of teamwork that allows to harmonize the teaching requirements with individual learning approach and helps to prepare pupils for planned work and independent knowledge acquisition and problem solving. The study has shown that complex IBL activities can be successfully applied at primary school 3rd grade level already. Our form of education with the wider use of modern information and communication technologies (ICT) was attractive for the learners and helped them to develop interdisciplinary relationships. The integrated e-learning has helped third grades to develop a deeper conceptual understanding of temperature and allowed them to prepare presentations to demonstrate their conceptual knowledge. The approach allowed pupils to gain key competencies in Science (discussion and presentation of results). It has also increased the pupils’ interest in Science in general and helped them to understand links between different subjects.
Perception of the Quality of Smart City Solutions as a Sense of Residents’ Safety
Authors: Żywiołek Justyna , Schiavone Francesco
Published: September 2021

Personalization, mobility, artificial intelligence, corporate life transferred to the online world—all these elements will shape all intelligent solutions, including those for cities in the future also in the field of energy management. A necessary condition is to determine which specific repetitive behaviors and features smart cities will have to meet in order to build an image among residents and adapt to their preferences and requirements and energy requirements. Smart cities were created to support residents in using various services, to give them the possibility of easy communication without time and local barriers. Therefore, high-quality smart solutions in cities significantly affect trust in the city and can affect its reputation. Given that the purpose of the article is to examine the perception of intelligent solutions also in the field of energy and their impact on the sense of privacy and security, different exchanges of perceptions of quality, the risks they pose to residents and their perception of what gives a picture, have been studied. The results of empirical research clearly showed that the safety and level of satisfaction with the activities carried out by the city have a significant impact on the perceived quality, which in turn has a positive impact on reputation. The authors proposed a methodology based on the Kano model for examining residents’ satisfaction in order to investigate undefined desires and identified and confirmed needs and to study the analysis of risk and potential threats. The study was in the form of a proprietary questionnaire that can be used in similar surveys on the satisfaction of residents; 2685 correctly completed questionnaires were analyzed and the results obtained after submission were included in management action plans. The city government has expressed an interest that the measures taken will be reviewed after one to two years.
A Novel Deep Clustering Method and Indicator for Time Series Soft Partitioning
Authors: Eid Alexandre , Clerc Guy , Mansouri Badr , Roux Stella
Published: September 2021

The aerospace industry develops prognosis and health management algorithms to ensure better safety on board, particularly for in-flight controls where jamming is dreaded. For that, vibration signals are monitored to predict future defect occurrences. However, time series are not labeled according to severity level, and the user can only assess the system health from the data mining procedure. To that extent, a clustering algorithm using a deep neural network core is developed. Time series are encoded into pictures to be fed into an artificially trained neural network: U-NET. From the segmented output, one-dimensional information on cluster frontiers is extracted and filtered without any parameter selection. Then, a kernel density estimation finally transforms the signal into an empirical density. Ultimately, a Gaussian mixture model extracts the latter independent components. The method empowered us to reveal different degrees of severity faults in the studied data, with their respective likelihoods, without prior knowledge. It was then compared to state-of-the-art machine learning algorithms. However, internal clustering results evaluation for time series is an open question. As the state-of-the-art indexes were not producing relevant results, a new indicator was built to fulfill this task. We applied the whole method to an actuator consisting of an induction machine linked to a ball screw. This study lays the groundwork for future training of diagnosis and prognosis structures in the health management framework.
Degradation Mechanism of Pressure-Assisted Sintered Silver by Thermal Shock Test
Authors: Wakamoto Keisuke , Otsuka Takukazu , Nakahara Ken , Namazu Takahiro
Published: September 2021

This paper investigates the degradation mechanism of pressure-sintered silver (s-Ag) film for silicon carbide (SiC) chip assembly with a 2-millimeter-thick copper substrate by means of thermal shock test (TST). Two different types of silver paste, nano-sized silver paste (NP) and nano-micron-sized paste (NMP), were used to sinter the silver film at 300 °C under a pressure of 60 MPa. The mean porosity (p) of the NP and MNP s-Ag films was 2.4% and 8%, respectively. The pore shape of the NP s-Ag was almost spherical, whereas the NMP s-Ag had an irregular shape resembling a peanut shell. After performing the TST at temperatures ranging from −40 to 150 °C, the scanning acoustic tomography (SAT) results suggested that delamination occurs from the edge of the assembly, and the delamination of the NMP s-Ag assembly was faster than that of the NM s-Ag assembly. The NMP s-Ag assembly showed a random delamination, indicating that the delamination speed varies from place to place. The difference in fracture mechanism is discussed based on cross-sectional scanning electron microscope (SEM) observation results after TST and plastic strain distribution results estimated by finite element analysis (FEA) considering pore configuration.
Multi-Stage Optimization of Induction Machines Using Methods for Model and Parameter Selection
Authors: Nell Martin , Kubin Alexander , Hameyer Kay
Published: September 2021

Optimization methods are increasingly used for the design process of electrical machines. The quality of the optimization result and the necessary simulation effort depend on the optimization methods, machine models and optimization parameters used. This paper presents a multi-stage optimization environment for the design optimization of induction machines. It uses the strategies of simulated annealing, evolution strategy and pattern search. Artificial neural networks are used to reduce the solution effort of the optimization. The selection of the electromagnetic machine model is made in each optimization stage using a methodical model selection approach. The selection of the optimization parameters is realized by a methodical parameter selection approach. The optimization environment is applied on the basis of an optimization for the design of an electric traction machine using the example of an induction machine and its suitability for the design of a machine is verified by a comparison with a reference machine.
Effect of CO2 Flooding on the Wettability Evolution of Sand-Stone
Authors: Fauziah Cut Aja , Al-Yaseri Ahmed , Al-Khdheeawi Emad , Jha Nilesh Kumar , Abid Hussein Rasool , Iglauer Stefan , Lagat Christopher , Barifcani Ahmed
Published: September 2021

Wettability is one of the main parameters controlling CO2 injectivity and the movement of CO2 plume during geological CO2 sequestration. Despite significant research efforts, there is still a high uncertainty associated with the wettability of CO2/brine/rock systems and how they evolve with CO2 exposure. This study, therefore, aims to measure the contact angle of sandstone samples with varying clay content before and after laboratory core flooding at different reservoir pressures, of 10 MPa and 15 MPa, and a temperature of 323 K. The samples’ microstructural changes are also assessed to investigate any potential alteration in the samples’ structure due to carbonated water exposure. The results show that the advancing and receding contact angles increased with the increasing pressure for both the Berea and Bandera Gray samples. Moreover, the results indicate that Bandera Gray sandstone has a higher contact angle. The sandstones also turn slightly more hydrophobic after core flooding, indicating that the sandstones become more CO2-wet after CO2 injection. These results suggest that CO2 flooding leads to an increase in the CO2-wettability of sandstone, and thus an increase in vertical CO2 plume migration and solubility trapping, and a reduction in the residual trapping capacity, especially when extrapolated to more prolonged field-scale injection and exposure times.
Adsorptive Recovery of Cd(II) Ions with the Use of Post-Production Waste Generated in the Brewing Industry
Authors: Kalak Tomasz , Walczak Jakub , Ulewicz Malgorzata
Published: September 2021

Post-production waste generated in the brewing industry was used to analyze the possibility of Cd(II) ion recovery in biosorption processes. Brewer’s grains (BG), which are waste products from beer manufacturing processes, are a promising material that can be reused for biosorption. The biomass contains appropriate functional groups from fats, proteins, raw fibers, amino acids, carbohydrates and starch, showing a strong affinity for binding metal ions and their removal from wastewater. The biosorbent material was characterized by several research methods, such as particle size distribution, elemental composition and mapping using SEM-EDX analysis, specific surface area and pore volume (BET, BJH), thermogravimetry, electrokinetic zeta potential, SEM morphology and FT-IR spectrometry. Initial and equilibrium pH, adsorbent dosage, initial metal concentration and contact time were parameters examined in the research. The highest biosorption efficiency was obtained at a level of 93.9%. Kinetics analysis of the processes and sorption isotherms were also carried out. Based on the conducted experiments, it was found that this material has binding properties in relation to Cd(II) ions and can be used for wastewater treatment purposes, being a low-cost biosorbent. This research studies are in line with current global trends of circular and sustainable economies.
Energy Performance Investigation of Bi-Directional Convergence Energy Prosumers for an Energy Sharing Community
Authors: Kim Min-Hwi , Lee Dong-Won , Kim Deuk-Won , An Young-Sub , Yun Jae-Ho
Published: September 2021

Due to the wide-spread use of photovoltaic (PV) systems, interest regarding economic benefit and energy-sharing from surplus electricity has been raised. In this study, decentralized thermal and electric convergence energy prosumers for an energy-sharing community are proposed. For the convergence energy system, a simultaneous heating and cooling heat pump (SHCHP) system integrated with a thermal network is proposed, and the energy performance and operating energy savings of the proposed system were investigated. A smart village located in the Busan Eco Delta Smart City was selected as a case study for the simulation analysis. Experimental data of the heat pump system were used to analyze the SHCHP. The analysis results showed that the proposed system could provide over 53% and 86% of the load cover and supply cover factors, respectively. The proposed system can earn economic benefits, such as energy trading from the surplus electricity of PV systems and thermal energy produced by an SHCHP, more than 30.5 times those of conventional air-source heat pump systems. These benefits mainly originate that a conventional system can trade the surplus electricity from a PV system but the proposed system can trade produced thermal energy from SHCHPs and the surplus electricity from PV systems.
Determining Information Quality in ICT Systems
Authors: Stawowy Marek , Duer Stanisław , Paś Jacek , Wawrzyński Wojciech
Published: September 2021

The article deals with the estimation of information quality (IQ) in information and communication technologies (ICT) systems. A number of recent publications were analyzed, as well as ISO standards concerning quality and information quality. Due to the limitations of the known methods of estimating IQ, the authors present their own proprietary concept based on multidimensional and multi-layer modeling using methods of estimating uncertainty. The modeling proposed in this publication uses sixteen dimensions of quality known from the literature. The features of dimensions are taken into account as another layer and information states as successive steps in the IQ model. An example of calculations is also presented in which the mathematical evidence method used in estimating the uncertainty is extended to the modeling of dependent elements. The article also presents a simulation based on the presented example. This simulation shows the assumed dependencies between the output and input values.
Investigation of Heat Transfer in a Large-Scale External Heat Exchanger with Horizontal Smooth Tube Bundle
Authors: Blaszczuk Artur , Jagodzik Szymon
Published: September 2021

In the research work, energy transport between a dense fluidized bed and submerged horizontal tube bundle is analyzed in the commercial external heat exchanger (EHE). In order to investigate the heat transfer behavior, the authors carried out eight performance tests in a fluidized bed heat exchange chamber with a cross-section of 2.7 × 2.3 m in depth and width and a height of 1.3 m. The authors have been developing a mechanistic model for the prediction of the average heat transfer coefficient, which includes the effect of the geometric structure of the tube bundle and the location of the heat transfer surface on the heat transfer rate. The computational results depict that the average heat transfer coefficient is essentially affected by superficial gas velocity and suspension density rather than bed particle size. The empirical correlations have been proposed for predicting heat transfer data since the existing literature data is not sufficient for industrial fluidized bed heat exchangers. On the basis of the evaluated operating conditions of an external heat exchanger, the optimal conditions where heat transfer occurs could be deduced. The developed mechanistic heat transfer model is validated by experimental data under the examined conditions.
GHG and NH3 Emissions vs. Energy Efficiency of Maize Production Technology: Evidence from Polish Farms; a Further Study
Authors: Konieczna Anita , Roman Kamil , Borek Kinga , Grzegorzewska Emilia
Published: September 2021

The paper determines the effect of selected cultivation technologies, including production chain energy inputs (growing, harvest, heap forming) on greenhouse gas emissions (GHGs) to the atmosphere. The data for the study was collected from 13 actually operating family farms ranging in size from 2 to 13 ha, located in the Podlaskie voivodship (Poland). GHG and ammonia (NH3) emissions from natural and mineral fertilisation as well as GHGs from energy carriers in a form of fuels (ON) were estimated. The average GHG emissions from the sources analysed were 1848.030 kg·CO2eq·ha−1 and 29.492 kg·CO2eq·t−1 of the green forage yield. The average NH3 emissions per hectare were 15,261.808 kg NH3 and 248.871 kg NH3·t−1 of yield. The strongest impact on the environment, due to the GHG emissions to the atmosphere, thus contributing to the greenhouse effect, is due nitrogen fertilisation, both mineral and natural. On average, in the technologies under study, 61% of the total GHG emissions came from fertilisation. The GHG emissions were correlated with the energy efficiency, calculated at the previous research stage, of the production technologies applied. There is a negative correlation (r = −0.80) between the features studied, which means that the higher the energy efficiency of the silage maize plantations, the lower the air pollution emissions in a form of the GHGs from the sources under study. It is so important to prevent environmental degradation to continue, conduct in-depth, interdisciplinary research on reducing the energy consumption of crop production technologies and striving to increase energy efficiency.
Effect of NACA0012 Airfoil Pitching Oscillation on Flow Past a Cylinder
Authors: Han Rong , Liu Wei , Yang Xiao-Liang , Chang Xing-Hua
Published: September 2021

The flow past a cylinder is a classical problem in flow physics. In a certain range of Reynolds number, there will be Karman vortex street phenomenon in the wake of a cylinder, which will greatly increase the pressure drag of the cylinder. By controlling the vortex shedding phenomenon, drag reduction of the cylinder could be effectively realized. In this paper, a NACA0012 airfoil with pitching oscillation is placed downstream of the cylinder. Based on the tight coupling method, kinematics equations and Navier–Stokes equations in the arbitrary Lagrangian–Eulerian form are solved. Firstly, the effect of airfoil oscillation period and the distance between airfoil leading edge and cylinder center (x/D) are studied respectively, especially considering the aspects of vortex shedding and drag reduction effect. Besides, the vortex interaction in the flow field around the airfoil and cylinder is analyzed in detail. It is found that the NACA0012 airfoil with pitching oscillation can change the period of vortex shedding. Moreover, it can also increase the drag reduction rate to as high as 50.5%, which presents a certain application prospect in the engineering drag reduction field, e.g., for launch vehicles, ship masts, submarine pipelines, etc.
Influence of LPG and DME Composition on Spark Ignition Engine Performance
Authors: Fabiś Paweł , Flekiewicz Bartosz
Published: September 2021

This article presents a detailed analysis of the potential of dimethyl ether (DME) fuel applications in SI engines. This paper presents the tests results completed on an 1.6-dm3 Opel Astra engine fueled by gaseous fuel as a mixture of LPG and DME. Dimethyl ether is a fuel with properties similar to liquid LPG fuel. In addition, DME is very well miscible with LPG, hence the possibility of creating a mixture with any DME divisions. The assessment of the possibility of using DME as a component of the mixture was carried out with the use of a chassis dynamometer and equipment, enabling an analysis of the changes taking place inside the cylinder. The results of the analyses are the parameters of the thermodynamic processes describing changes in the engine cylinder.
Cold Microfiltration as an Enabler of Sustainable Dairy Protein Ingredient Innovation
Authors: France Thomas C. , Kelly Alan L. , Crowley Shane V. , O’Mahony James A.
Published: September 2021

Classically, microfiltration (0.1–0.5 µm) of bovine skim milk is performed at warm temperatures (45–55 °C), to produce micellar casein and milk-derived whey protein ingredients. Microfiltration at these temperatures is associated with high initial permeate flux and allows for the retention of the casein fraction, resulting in a whey protein fraction of high purity. Increasingly, however, the microfiltration of skim milk and other dairy streams at low temperatures (≤20 °C) is being used in the dairy industry. The trend towards cold filtration has arisen due to associated benefits of improved microbial quality and reduced fouling, allowing for extended processing times, improved product quality and opportunities for more sustainable processing. Performing microfiltration of skim milk at low temperatures also alters the protein profile and mineral composition of the resulting processing streams, allowing for the generation of new ingredients. However, the use of low processing temperatures is associated with high mechanical energy consumption to compensate for the increased viscosity, and thermal energy consumption for inline cooling, impacting the sustainability of the process. This review will examine the differences between warm and cold microfiltration in terms of membrane performance, partitioning of bovine milk constituents, microbial growth, ingredient innovation and process sustainability.
Conditions of In Vitro Biofilm Formation by Serogroups of Listeria monocytogenes Isolated from Hass Avocados Sold at Markets in Mexico
Authors: Avila-Novoa María Guadalupe , Navarrete-Sahagún Velia , González-Gómez Jean Pierre , Novoa-Valdovinos Carolina , Guerrero-Medina Pedro Javier , García-Frutos Ramón , Martínez-Chávez Liliana , Martínez-Gonzáles Nanci Edid , Gutiérrez-Lomelí Melesio
Published: September 2021

Listeria monocytogenes is an important pathogen that has been implicated in foodborne illnesses and the recall of products such as fruit and vegetables. This study determines the prevalence of virulence-associated genes and serogroups and evaluates the effects of different growth media and environmental conditions on biofilm formation by L. monocytogenes. Eighteen L. monocytogenes isolates from Hass avocados sold at markets in Guadalajara, Mexico, were characterized by virulence-associated genes and serogroup detection with PCR. All isolates harbored 88.8% actA, 88.8% plcA, 83.3% mpl, 77.7% inlB, 77.7% hly, 66.6% prfA, 55.5% plcB, and 33.3% inlA. The results showed that 38.8% of isolates harbored virulence genes belonging to Listeria pathogenicity island 1 (LIPI-1). PCR revealed that the most prevalent serogroup was serogroup III (1/2b, 3b, and 7 (n = 18, 66.65%)), followed by serogroup IV (4b, 4d–4e (n = 5, 27.7%)) and serogroup I (1/2a–3a (n = 1, 5.5%)). The assessment of the ability to develop biofilms using a crystal violet staining method revealed that L. monocytogenes responded to supplement medium TSBA, 1/10 diluted TSBA, and TSB in comparison with 1/10 diluted TSB (p < 0.05) on polystyrene at 240 h (p < 0.05). In particular, the biofilm formation by L. monocytogenes (7.78 ± 0.03–8.82 ± 0.03 log10 CFU/cm2) was significantly different in terms of TSBA on polypropylene type B (PP) (p < 0.05). In addition, visualization by epifluorescence microscopy, scanning electron microscopy (SEM), and treatment (DNase I and proteinase K) revealed the metabolically active cells and extracellular polymeric substances of biofilms on PP. L. monocytogenes has the ability to develop biofilms that harbor virulence-associated genes, which represent a serious threat to human health and food safety.
The Economic and Psychological Impacts of COVID-19 Pandemic on Indian Migrant Workers in the Kingdom of Saudi Arabia
Authors: Khan Mohammed Arshad , Khan Md Imran , Illiyan Asheref , Khojah Maysoon
Published: September 2021

The ongoing Coronavirus disease 2019 (COVID-19) pandemic has changed the working environment, occupation, and living style of billions of people around the world. The severest impact of the coronavirus is on migrant communities; hence, it is relevant to assess the economic impact and mental status of the Indian migrants. This study is quantitative in nature and based on a sample survey of 180 migrant workers. Descriptive statistics, chi-square test, dependent sample t-test, and Pearson’s correlation coefficient were utilized to analyze the surveyed data. The findings of the study reveal, through the working experience of the migrants, that new international migration has reduced due to lockdown and international travel restrictions. It was also reported that the majority of the migrants worked less than the normal working hours during the lockdown, causing a reduction of salary and remittances. Chi-square test confirms that the perceptions of migrants towards the COVID-19 management by the government were significantly different in opinion by different occupation/profession. Majority of the sampled migrants reported the problem of nervousness, anxiety, and depression; however, they were also hopeful about the future. The psychological problem was severe for the migrants above the age of 40, not educated, and with a higher number of family members. Subsequently, the policy implications from the findings of the research can draw attention of the policy makers towards protective measures which need to be implemented to support migrants during the ongoing pandemic. The government should take some necessary steps, such as a financial benefit scheme, to overcome the problems in the reduction of migrant earnings and remittances. The government should not focus only on vaccination and physical fitness of the migrants but also need to find out the cure of the psychological impact arising during the pandemic.