bluuebunny/crossref_metadata_2025 huggingface dataset:
Amplitude da gestão da(s) diversidade(s) - implicações organizacionais e sociais.
Authors: PINHEIRO JOAO LUIS ALVES , GOIS JOAO BOSCO HORA
Published: November 2020

Esse trabalho busca através da revisão da literatura apresenta casos concretos, identificar alguns dos diferentes eixos da(s) diversidade(s) (geracional, racial, gênero, por orientação sexual, deficiência física e cultural-imigracional). Dessa forma, a gestão da(s) diversidade(s) possibilita novos desafios e oportunidades aos profissionais que estiverem capacitados a lidar com essa realidade que se descortina para as organizações. Esses novos segmentos sociais, tem demandas específicas, tanto para ofertar novos agentes para as organizações, assim como abre a possibilidade de ofertar produtos e serviços específicos a tais públicos. Cabe destaque a associação do trabalho com a questão da globalização, suas possibilidades e limitações, quando percebe-se que esse é um processo contínuo e constante. As fronteiras entre as sociedades e países estão tênues, o que pode ser parcialmente explicado pelo avanço dos instrumentos de comunicação e o avanço do conhecimento, o que demanda revisão de paradigmas. O trabalho ainda apresenta a evolução e as interfaces entre a diversidade, a responsabilidade social e a sustentabilidade.
Editorial
Authors: Trevisan Leonardo , Dutra Joel Souza , Veloso Elza
Published: November 2020

O mundo do trabalho convive com inédita velocidade de mudança nos formatos de exercício profissional. O Brasil não é exceção neste processo. O primeiro fator impulsionador dessas mudanças é a internacionalização das expectativas organizacionais. Parâmetros e critérios de comparação de tais expectativas deixaram de ser, sequer, regionais. O porte da empresa também não inibe mais a comparação internacionalizada. A constante demanda por integração às cadeias globais de produção, tanto na esfera produtiva, como na prestação de serviço, gera inevitável pressão de mudança nos regimes de trabalho. Buscar referência “além fronteiras” é só o primeiro novo formato nos regimes de trabalho.
FORMAÇÃO DAS COMPETÊNCIAS DO ESTRATEGISTA: UM ESTUDO DOS OFICIAIS DA POLÍCIA MILITAR
Authors: Fernandes Ciro Antonio , Venelli-Costa Luciano , Vieira Almir Martins , Amorim Wilson Aparecido Costa de
Published: November 2020

Este trabalho tem por objetivo identificar como são formadas as competências do principal agente estratégico da organização, denominado “o estrategista”. O enfoque conceitual se concentra nos trabalhos de Fleury e Fleury (2001) e de Ruas (2008), em relação às competências, e Whittington (1992, 2004) para proposições a respeito de estratégia. Enquanto postura metodológica, assumiu-se uma abordagem qualitativa, com apoio na história oral, instrumentalizada por entrevista sem profundidade. Participaram da pesquisa 11 oficiais da Polícia Militar do Estado de São Paulo. Quanto aos resultados, depreendeu-se que a formação do estrategista está fortemente vinculada à formação militar, ainda que importantes aspectos se originem nas relações familiares e escolares, consolidando valores que irão balizar suas ações e posturas no decorrer da vida.
IDENTIFICAR PESSOAS PARA ASSUMIR POSIÇÕES DE MAIOR COMPLEXIDADE NO CONTEXTO DO PROCESSO SUCESSÓRIO: UM MODELO TEÓRICO
Authors: Ohtsuki Celi Hiromi
Published: November 2020

A literatura sobre sucessão não esclarece como as organizações identificam pessoas aptas para  assumir atribuições e responsabilidades de liderança de maior complexidade. Com base nas teorias de níveis de complexidade e de liderança, este ensaio propõe um modelo teórico que sirva para mais bem delinear futuros estudos sobre esta questão, relevante na estruturação de um processo sucessório efetivo.
Administração pública: a importância de uma carreira em uma universidade pública do estado do paraná
Authors: Primak Irineu , Stefano Silvio Roberto , Andrade Sandra Mara de , Zampier Marcia Aparecida
Published: November 2020

Este artigo tem por objetivo analisar a Carreira Técnica Universitária, de umaUniversidade Pública do Estado Paraná, procurando saber qual o grau de satisfaçãoque essa carreira tem proporcionado agentes universitários. A metodologia utilizadafoi a descritiva, realizada a partir de leitura de livros e artigos, pesquisas bibliográficas,referências de revistas, textos da internet e demais periódicos dos últimos cinco anos.A fonte de pesquisa principal foi a consulta realizada aos servidores, por meio de umquestionário eletrônico disponível na página do Google drive, e encaminhado via e-mail,cujas respostas foram consideradas satisfatórias para análise dos resultados pretendidos.
Gestão por competências no setor público: exemplos de organizações que adotaram o modelo.
Authors: Fevorini Fabiana Bittencourt , Silva Rogerio Tadeu , Crepaldi Ana Maria
Published: November 2020

Este trabalho tem o objetivo de aprofundar os conhecimentos sobre a adoção dagestão por competências em organizações públicas. Foram utilizados dados da pesquisa“As Melhores Instituições Públicas para Você Trabalhar” realizada Programa de Gestão dePessoas (PROGEP) da Fundação Instituto de Administração (FIA) em parceria com a revistaVocê S.A da Editora Abril, em 2013. Através das respostas a uma questão aberta sobre otema, pretende-se analisar como estas organizações usam a gestão por competências emsuas práticas de recursos humanos.
PROGRAMAS TRAINEE E EXPATRIAÇÃO COMO FATORES PROPULSORES DE ASCENSÃO NA CARREIRA
Authors: Bitencourt Betina Magalhães , Gallon Shalimar , Scheffer Angela Beatriz Busato
Published: November 2020

O planejamento e desenvolvimento da carreira não ocorrem isoladamente dos fatores ambientais e pessoais, envolvendo também as ambições profissionais do indivíduo, assim como as propostas da empresa. Destacam-se, neste meio, dois projetos empresariais como forma de desenvolvimento e movimentação dos profissionais: os programastrainee e a expatriação. Estes envolvem grande investimento, tanto por parte da empresa, como do profissional, que mobiliza os seus esforços em busca de aprendizagem e reconhecimento pelo seu trabalho. Este estudo busca analisar o programa trainee e o processo de expatriação em duas empresas brasileiras a fim de entender como esses influenciaram na carreira dos entrevistados.
RIGHTS-BASED APPROACHES TO IMPROVING FOOD AVAILABILITY FOR TAMARIKI MĀORI: A narrative literature review and theory-based synthesis
Authors: McKerchar Christina , King Paula , Lacey Cameron , Abel Gillian , Signal Louise
Published: November 2020

Food availability refers to the adequacy of the supply of healthy food. It is a key concern for the wellbeing of tamariki Māori today. A narrative literature review methodology was applied to examine the literature and identify influences that enable the availability of healthy food for tamariki. Findings were synthesised and analysed using the Oranga Mokopuna framework—a rights-based approach grounded in tikanga Māori. Factors enabling healthy food availability for tamariki involve the fulfilment of their rights to (a) an environment that enables access to traditional foods and food practices, (b) be involved in decisions about their food environment, (c) the right to adequate food and (d) the highest attainable standard of health (and within this) to be protected from food marketing. There is limited evidence that the New Zealand government is meeting these obligations to tamariki. Thus, the right to healthy food needs to urgently be embedded across legislation, policy and practices.
GLASS CEILINGS IN NEW ZEALAND UNIVERSITIES: Inequities in Māori and Pacific promotions and earnings
Authors: McAllister Tara G. , Kokaua Jesse , Naepi Sereana , Kidman Joanna , Theodore Reremoana
Published: November 2020

Māori and Pacific academics make up less than 4% and 1% respectively of New Zealand professors. We investigated ethnic inequities in promotions and earnings in New Zealand universities. Using New Zealand’s Performance-Based Research Fund (PBRF) data (2003, 2012, 2018) we found that Māori and Pacific men and also women academics, compared with non-Māori non-Pacific men academics, had significantly lower odds of being an associate professor or professor (professoriate) or of being promoted, and had lower earnings. These inequities were not explained by research performance (measured by PBRF scores), age or field, and remained over time, particularly for women. Māori and Pacific women academics earned on average $7,713 less in 2018 than non-Māori non-Pacific men academics and had 65% lower odds of being promoted into the professoriate from 2003 to 2018. Our findings suggest that current inequities for Māori and Pacific academics will persist without systemic change in New Zealand universities.
Estrategia metodológica para desarrollar la competencia de resolución de problemas matemáticos en los estudiantes de secundaria de una institución educativa privada de Lima
Authors:   , Mendoza Gonzales Joseph Hatson
Published: November 2020

La investigación se orientó a diseñar una estrategia metodológica para desarrollar la competencia de resolución de problemas matemáticos en los estudiantes de V de Secundaria de institución educativa privada de Lima.
Planeamiento estratégico “Bodega Moquillaza S.A.C.”
Authors:   , Borja Calle Paul Antonio
Published: November 2020

En el presente trabajo de tesis se ha desarrollado el planeamiento estratégico para la empresa Bodega Moquillaza S.A.C. la cual se dedica a la elaboración y comercialización de pisco, para el periodo que va desde el 2017 al 2021.
Ultrastructural analysis of berry skin from four grapes varieties at harvest and in relation to postharvest dehydration
Authors: Brizzolara Stefano , Minnocci Antonio , Yembaturova Elena , Tonutti Pietro
Published: November 2020

In several production areas, dessert (sweet) and reinforced wines are made after a more or less intense dehydration of harvested grapes. The dehydration process depends on several factors, including the size, morphology and anatomy of the berries, all genetically defined traits that can be affected by vineyard management and microclimate conditions. At harvest, berry outer surface and skin ultrastructural features of cvs Aleatico, Sagrantino, Sangiovese and Trebbiano berries were investigated in a frozen-hydrated state using cryo‑scanning electron microscopy (Cryo‑SEM). The berries were subjected to postharvest dehydration at 23 °C for twelve days and the differences in weight loss were determined. In terms of weight loss rate, Aleatico and Trebbiano were the fastest and the slowest respectively. Therefore, the ultrastructural changes of berry skin of these two varieties were also investigated at the end of the dehydration process. At harvest, the structure of the epicuticular waxes on the skin outer surface differed between berries of different cultivars. The thickness of the cuticle, epidermis and hypodermis was also found to be significantly different, with Trebbiano berries having the thickest skin. At the end of the dehydration process all the measured parameters decreased, in particular Aleatico epicuticular wax, hypodermis and cuticle thickness, as well as the hypodermis cell wall and the mesocarp parenchyma cell area. The high weight loss rate recorded for Aleatico can be partly explained by the thickness of the berry skin at harvest, which was significantly thinner than that of Trebbiano, as well as by other skin-related morphological and histological factors possibly affecting permeability.
Self-Healing Biogeopolymers Using Biochar-Immobilized Spores of Pure- and Co-Cultures of Bacteria
Authors: Doctolero Jadin Zam S. , Beltran Arnel B. , Uba Marigold O. , Tigue April Anne S. , Promentilla Michael Angelo B.
Published: November 2020

A sustainable solution for crack maintenance in geopolymers is necessary if they are to be the future of modern green construction. This study thus aimed to develop self-healing biogeopolymers that could potentially rival bioconcrete. First, a suitable healing agent was selected from Bacillus subtilis, B. sphaericus, and B. megaterium by directly adding their spores in the geopolymers and subsequently exposing them to a large amount of nutrients for 14 days. SEM-EDX analysis revealed the formation of biominerals for B. subtilis and B. sphaericus. Next, the effect of biochar-immobilization and co-culturing (B. sphaericus and B. thuringiensis) on the healing efficiencies of the geopolymers were tested and optimized by measuring their ultrasonic pulse velocities weekly over a 28-day healing period. The results show that using co-cultured bacteria significantly improved the observed efficiencies, while biochar-immobilization had a weak effect but yielded an optimum response between 0.3-0.4 g/mL. The maximum crack width sealed was 0.65 mm. Through SEM-EDX and FTIR analyses, the biominerals precipitated in the cracks were identified to be mainly CaCO3. Furthermore, image analysis of the XCT scans of some of the healed geopolymers confirmed that their pulse velocities were indeed improving due to the filling of their internal spaces with biominerals. With that, there is potential in developing self-healing biogeopolymers using biochar-immobilized spores of bacterial cultures.
Contemporary Status of Acute Myocardial Infarction in Korean Patients: Korean Registry of Acute Myocardial Infarction for Regional Cardiocerebrovascular Centers
Authors: Kim Rock Bum , Hwang Jin Yong , Park Hyun-Woong , Her Ae-Young , Lee Jang-Hoon , Kim Moo Hyun , Yoon Chang Hwan , Cho Jae Young , Woo Sung-Il , Kim Yongcheol , Han Jae-Young , Choi Joon Hyouk , Kim Song Yi , Choi Si-Wan , Jee Sung Ju , Lee Sang Yeub , Won Ki-Bum , Park Kyeong-Soo , Hyun Dae Woo
Published: November 2020

Background: This study aimed to present the development process and characteristics of the Korean Registry of Acute Myocardial Infarction for Regional Cardiocerebrovascular Centers (KRAMI-RCC). Methods: We developed KRAMI-RCC, a web-based registry for patients with AMI. Patients from 14 RCCs were registered for more than 3 years from July 2016. It includes an automatic error-checking system, and user training and on-site monitoring are performed to manage data quality. Results: A total of 11,700 AMI patients were registered in KRAMI-RCC over 3 years (73.9% men). The proportions of patients with ST-elevation and non-ST-elevation myocardial infarction at discharge were 43.4% and 56.6%, respectively. Of the total 3-year patients, 5.6% died in the hospital and 4.4% died 12 months after discharge. The case fatality within 12 months was 9.7%. Prehospital care data showed delayed arrival time after onset of symptoms (median 153 min) and low transportation rate by public ambulance (25.2%). Post-hospital care data showed lower participation rate in the second rehabilitation program (16.8%). Conclusions: The recently developed KRAMI-RCC registry has been more focused on pre-hospital and post-hospital data, which will be helpful in understanding the current state of AMI disease management and in making policy decisions to reduce case fatality in Korea.
Geometric Morphometric Data Augmentation using Generative Computational Learning Algorithms
Authors: Courtenay Lloyd A. , González-Aguilera Diego
Published: November 2020

The fossil record is notorious for being incomplete and distorted, frequently conditioning the type of knowledge that can be extracted from it. In many cases, this often leads to issues when performing complex statistical analyses, such as classification tasks, predictive modelling, and variance analyses, such as those used in Geometric Morphometrics. Here different Generative Adversarial Network architectures are experimented with, testing the effects of sample size and domain dimensionality on model performance. For model evaluation, robust statistical methods were used. Each of the algorithms were observed to produce realistic data. Generative Adversarial Networks using different loss functions produced multidimensional synthetic data significantly equivalent to the original training data. Conditional Generative Adversarial Networks were not as successful. The methods proposed are likely to reduce the impact of sample size and bias on a number of statistical learning applications. While Generative Adversarial Networks are not the solution to all sample-size related issues, combined with other pre-processing steps these limitations may be overcome. This presents a valuable means of augmenting geometric morphometric datasets for greater predictive visualization.
Quantum Determinism of Relative Spacetime Counting
Authors: Machusky Eugene , Lisovska Ljubov , Goncharov Olexander
Published: November 2020

The phenomenal mathematical efficiency of quantum field theories in modern high-speed information and communication systems has a very simple explanation from the point of view of common sense and higher mathematical logic: all of them – quantum cosmology, quantum physics, quantum metrics and quantum calculus – are the self-informational mathematical systems based on symbolic and numerical functional analysis and elementary recursive calculations of interrelated space and time parameters of matter motion in various states of the material environment.For the first time in scientific and engineering practice, it was clearly shown that the information entropy of both standard symbolic and non-standard numerical functional analysis has absolute exact limits of computational accuracy – 1/10^16 and 1/10^64, respectively. Moreover, the second limit determines the maximum level of accuracy of practical quantum metrics and calculations and fully coordinates four branches of classical physics – thermodynamics, electrodynamics, gravidynamics, chromodynamics with special and general relativity.
40-Hz Auditory Steady State Response (ASSR) as a Biomarker of Abnormalities in SHANK3 Gene: a Case-Report of 15-years Old Girl with Rare Microduplication in 22q13.33
Authors: Neklyudova Anastasia K , Portnova Galina V , Rebreikina Anna B , Voinova Victoria Yu , Sysoeva Olga V
Published: November 2020

SHANK3 encodes scaffold protein involved in postsynaptic receptor density in glutamatergic synapses, including those in the parvalbumin (PV)+inhibitory neurons – the key players in generation of sensory gamma oscillations, such as 40-Hz auditory steady-state response(ASSR). Here we describe a clinical and neurophysiological phenotype of a 15-years old girl (SH01) with microduplication of 16389 bp in 22q13.33, affecting the SHANK3 gene in comparison to typically developing children (n=32). EEG were recorded during the binaurally presentation of 40-Hz clicks’ trains lasting for 500 ms with inter-trial intervals 500-800 ms. SH01 was diagnosed with mild mental retardation and learning disabilities(F70.88) and had problems with reading and writing, as well as smaller vocabulary than TD peers. Her clinical phenotype generally resembled the phenotype of previously described patients with 22q13.33 microduplication. SH01 had mild autistic symptoms but below the threshold for ASD diagnosis. No seizures or MRI abnormalities were reported. While SH01 had relatively preserved auditory event-related potential(ERP) with slightly attenuated P1, her 40-Hz ASSR was totally absent significantly deviating from TD’s ASSR. Absence of 40-Hz ASSR in patient with microduplication, affected SHANK3 gene, indicates deficient temporal resolution of the auditory system, that might underlie language problems, and represent neurophysiological biomarker of SHANK3 abnormalities.
Laser-Based People Detection and Obstacle Avoidance for a Hospital Transport Robot
Authors: Zheng Kuisong , Wu Feng , Chen Xiaoping
Published: November 2020

This paper describes the development of a laser-based people detection and obstacle avoidance algorithm for a differential-drive robot, which is used for transporting materials along a reference path in hospital domains. Detecting humans from laser data is an important functionality for the safety of navigation in the shared workspace with people. Nevertheless, traditional methods normally utilize machine learning techniques on hand-crafted geometrical features extracted from individual clusters. Moreover, the datasets used to train the models are usually small and need to manually label every laser scan, increasing the difficulty and cost of deploying people detection algorithms in new environments. To tackle these problems, (1) we propose a novel deep learning-based method, which uses the deep neural network in a sliding window fashion to effectively classify every single point of a laser scan. (2) To increase the speed of inference without losing performance, we use a jump distance clustering method to decrease the number of points needed to be evaluated. (3) To reduce the workload of labeling data, we also propose an approach to automatically annotate datasets collected in real scenarios. In general, the proposed approach runs in real-time, performs much better than traditional methods, and can be straightforwardly extended to 3D laser data. Secondly, conventional pure reactive obstacle avoidance algorithms can produce inefficient and oscillatory behaviors in dynamic environments, making pedestrians confused and possibly leading to dangerous reactions. To improve the legibility and naturalness of obstacle avoidance in human crowded environments, we introduce a sampling-based local path planner, similar to the method used in autonomous driving cars. The key idea is to avoid obstacles by switching lanes. We also adopt a simple rule to decrease the number of unnecessary deviations from the reference path. Experiments carried out in real-world environments confirmed the effectiveness of the proposed algorithms.
Physiological and Yield of Soybean Under Kayu Putih (Melaleuca cajuputi subsp. cumingiana) Stands with N, P, and K Fertilization on Lithic Haplustert
Authors: Ismoyojati Roni , Tohari Tohari , Suryanto Priyono , Putra Fajrin Pramana
Published: November 2020

Fertilization of N, P, and K on soybean planted under Kayu Putih stands to serve to increase soil nutrients. Lithic Haplustert is a subgroup of Vertisol with a relatively low fertility and organic matter with a heavy clay texture. This research aims to determine the response of soybean to the application of N, P, and K fertilizers on the Lithic Haplustert in physiology and yield. This research was conducted from February to May 2015 in the Srikoyo hamlet, Menggoran village, Playen district, Gunungkidul regency, Yogyakarta. The experimental design is split-split plot with three levels of fertilization of N (0, 25, 50 kg urea ha-1), P (0, 150, 300 kg SP-36 ha-1), and K (0, 75, 150 kg KCl ha-1). The results showed that the application of 50 kg urea ha-1 and 300 kg SP-36 ha-1 can increase the leaf area and photosynthesis rate. Dosage 150 kg KCl ha-1 fertilizer increased the concentration of N, P, and K in the plant tissues significantly.
Skrining dan Efektivitas Metabolit Sekunder Mikania micrantha pada Gulma Jajagoan serta Dampaknya terhadap Padi Sawah
Authors: Alridiwirsah Alridiwirsah , Tampubolon Koko , Sihombing Fransisca Natalia , Barus Wan Arfiani , Syofia Irna , Zulkifli Tengku Boumedine Hamid , Purba Zavandri
Published: November 2020

Secondary metabolites from Mikania micrantha could be expected to control barnyardgrass (Echinochloa crus-galli) characteristics and have an effect on lowland rice. This research was aimed to screening of secondary metabolites in M. micrantha extract, obtaining the greater extract concentration in suppressing the barnyardgrass growth, and determine the impact on the lowland rice characteristics. This method used was Randomized Completely Block Design in non-factorial within the concentration rates of M. micrantha extract using ethanol 96% (0%; 20%; 40%; 60%; 80%; 100%, and herbicide 2,4-D dimethylamine at the dose of 1 l ha-1 as a comparison). Lowland rice and barnyardgrass characteristics were analyzed using F-test and followed by DMRT at 5% with SPSS software. The result showed that M. micrantha had secondary metabolites include alkaloids, flavonoids, and tannins. The concentration at 20 to 100% significantly decreased the fresh- and dry-weight of barnyardgrass with the highest suppressing found in 60% concentration by 65.91% and 67.92%, respectively compared to un-sprayed. The concentrations at 20% and 60% were classified as inhibiting the growth biomass of barnyardgrass. The concentrations at 20%, 60%, and 80% can still encourage the tillers growth of lowland rice. An extract concentration of M. micrantha at 20% can be applied to inhibit the growth of barnyardgrass biomass and stimulate the lowland rice tillers.
Sirenas caníbales y strippers en el cine: la feminidad monstruosa en The Lure (2015) de Agnieszka Smoczynska
Authors: Jiménez Gómez Cristina
Published: November 2020

La sirena opera como una figura cambiante, producto de las transformaciones y recreaciones que ha sufrido a través de los discursos artísticos en el tiempo, desde los relatos literarios de la Antigüedad grecolatina y el cuento de Hans Christian Andersen en 1837 hasta las artes plásticas con la pintura, escultura y arquitectura. Este estudio explora la configuración cinematográfica de la sirena a partir de la mirada feminista y posmoderna de Agnieszka Smoczyńska en su film The Lure (2015). La realizadora propone dos modelos sanguinarios, vinculados con el género de terror, que sugieren no solo la objetivación y mercantilización del cuerpo femenino en el ambiente nocturno varsoviano de los años ochenta, sino también su iniciación y liberación sexual al margen los parámetros establecidos.
Los peligros de la (in)comunicación: Intimidad de los parques y los relatos de Cortázar
Authors: Ros Cases Laura
Published: November 2020

El presente trabajo estudia el proceso de creación de la película Intimidad de los parques (1965), dirigida por Manuel Antín y basada en los relatos «El ídolo de las Cícladas» y «Continuidad de los parques» (1964) de Julio Cortázar. Para ello, estableceremos las nuevas maneras de interacción entre la literatura y el cine que propone la generación del 60, a la cual pertenece el director argentino. A lo largo de este artículo presentaremos los puntos de contacto entre los relatos, el guion y la película resultante de este intercambio a través de diversos elementos. De un lado, analizaremos la relación entre la temporalidad cíclico-fantástica y el montaje de correspondencias; de otro, veremos las implicaciones de la problemática del lenguaje y los efectos que produce mediante los patrones de incomunicación a los que se ven sometidos los personajes.
Ursúa, historia de una ficción
Authors: Segura Acevedo Yadira
Published: November 2020

Ursúa es la primera novela del escritor colombiano William Ospina que da inicio a su trilogía del Amazonas, inscrita en el género de la Nueva Novela Histórica. Dentro de este escenario narrativo, el autor construye una mirada distinta del proceso de conquista y colonización del territorio americano, a través de la vida del conquistador navarro Pedro de Ursúa. En esta obra se hipertextualizan relatos polifónicos, protagonizados por personajes históricos y ficticios; hechos que, visto desde un enfoque semiótico, evidencian la historia y la ficción como realidades sígnicas. En efecto, la hermenéutica literaria se decodificará a partir de la teoría semiótica del filósofo norteamericano Charles Sanders Peirce, con el fin de encontrar una vía de acceso a los diferentes niveles interpretativos del relato literario e historiográfico.
Shelf-edge delta and reef development on a mixed siliciclastic–carbonate margin, central Great Barrier Reef
Authors: Daniell James , Manoy Thomas , Beaman Robin J. , Webster Jody M. , Puga-Bernabéu Ángel
Published: November 2020

The Great Barrier Reef (GBR) is the world's largest extant mixed silicilastic–carbonate margin. Previous research on the Great Barrier Reef has suggested that the extensive barrier reef system may act as an impermeable barrier and limit the development of delta systems during lowstands, but sufficient geophysical data to support this hypothesis are lacking. We use dense sparker seismic and sub-bottom profiler data to better understand the structure of a large lobe-shaped feature (∼ 10 km × 10 km) on the shelf edge of the central GBR and the interactions between siliciclastic and carbonate sedimentary systems. Interpreted sparker seismic contains prograding clinoforms and suggest that the lobe-shaped feature was a river-dominated shelf-edge delta. A delta on the shelf edge implies that the presence of an exposed barrier reef was not a major impediment to deposition and that other adjacent lobe-shaped features are also deltaic deposits. The shelf-edge deltas were deposited onto a broad upper-slope terrace that allowed continued progradation and limited incision when sea level fell below the shelf edge. Delta foresets are commonly colonized by coral reefs, but the spatial and temporal relationship between reefs and some deltaic units remains unclear. The presence of multiple shelf-edge deltas that link to previously mapped Burdekin River paleo-channels indicates a complex history of sedimentation, with the Burdekin River delta migrating up to 100 km along the GBR margin during the late Quaternary. Regional bathymetric data suggest that large modern or recent shelf-edge deltas are rare on the GBR and that there was a broad range of sedimentary processes operating along the margin of the GBR during periods of low sea level.
Refinement of the stratigraphic framework for the Regional C depositional unit of the McMurray Formation and implications for the early transgression of the Alberta Foreland Basin, Canada
Authors: Château Chloé C.F. , Dashtgard Shahin E. , MacEachern James A.
Published: November 2020

The Lower Cretaceous McMurray Formation in Alberta and Saskatchewan, Canada, comprises a series of depositional units (DUs) consisting of stacked parasequences bounded by flooding surfaces and incised by fluvio-estuarine channel belts. The fluvio-estuarine channel belts of the McMurray Fm have been the focus of numerous studies whereas the regional DUs have received substantially less attention. Of the regional DUs, Regional C (equivalent to the middle McMurray) is the most understudied, yet this interval records the history of the McMurray Formation between deposition of fluvial strata in the lower McMurray and marine facies in the upper McMurray and overlying Clearwater Formation. Determining the history of the Regional C DU is fundamental for accurately reconstructing the stratigraphic evolution of the McMurray Fm and, by extension, the early evolution of the Alberta Foreland Basin.

The Regional C is divided into two DUs separated by a regionally mappable flooding surface. This surface occurs 11 to 15 m below the top of the Regional C and is traceable over a 2,550 km2 area. This flooding surface divides the thick interval of undifferentiated Regional C into a lower C2 DU and an upper C1 DU, each with a maximum thickness of < 15 m. The thickness of the C2 and C1 DUs indicates that deposition at this time also occurred in a setting of low to moderate accommodation creation, which is consistent with the rest of the McMurray Formation. The limited available accommodation space was easily surpassed by sediment supplied by the paleo-distributive channel system, leading to a basinward progradation of the shoreline.

The C2 and C1 DUs are retrogradationally stacked, with the maximum regressive paleo-shoreline of C1 lying landward of that of C2. This stacking arrangement indicates that the shoreline backstepped during the early stages of transgression of the Boreal Sea. The backstepping of the paleo-shoreline from C2 to C1 time is consistent with previous studies that show continued and stepwise retrogradation and/or transgression of the paleo-shoreline from the onset of deposition in the lower McMurray Formation through to maximum transgression in the Clearwater Formation. Together, these studies demonstrate that the early drowning of the Alberta Foreland Basin was persistent and slow.
Development of inter-lava drainage systems in LIPs: The Columbia River Flood Basalt Province (U.S.A.) as a case study
Authors: Ebinghaus Alena , Taylor Ross , Barker Aaron , Hartley Adrian J. , Jolley David W. , Hole Malcolm J.
Published: November 2020

Volcanism in large igneous provinces (LIPs) is understood to have had the potential to affect global environments and ecosystems, triggering mass extinctions, climate change, and ocean acidification. However, basin-scale studies sediment distribution and sedimentary-system development in LIP lava fields are sparse and often limited to localized exposure. To gain a better understanding of the controls on inter-lava sedimentology across a continental LIP, a new sedimentological data set is presented from the Miocene Columbia River Flood Basalt Province (CRBP), situated in the Columbia Basin in south-central Washington State, northeast Oregon and eastern Idaho. Based on the qualification and quantification of sedimentary facies, petrography, paleoflow, channel dimensions, and catchment size from 96 sites across the Columbia Basin, a refined model of regional and local environmental change, integrating local volcanic and tectonic evolution, is presented. Here, CRBP stratigraphy is divided into six distinctive sedimentation intervals, which allows correlation of sedimentary interbeds formed in the western part and in the eastern part of the basin. The model describes and reviews drainage-system development and discusses the control of volcanic and tectonic activity on sediment distribution in the CRBP lava field at local to basin scale. The data presented here largely support findings of previous works suggesting a highly complex interplay between sedimentary, volcanic, and tectonic evolution of the area. In addition, it elaborates on the aspects of sediment–lava interaction and indicates that individual sub-basins in the CRBP formed separated depositional settings, emphasizing the lateral complexity of inter-lava sedimentation. Importantly, this work improves our understanding of sediment–lava relationships in continental LIPs and helps in building more generic models for sediment distribution in volcanic terranes where exposure is limited or absent.
Induction of different human enteroendocrine cells in intestinal organoids
Authors: Clevers Hans , Beumer Joep
Published: November 2020

Intestinal enteroendocrine cells \(EECs) are key players in mammalian physiology as largest endocrine organ, and regulate metabolic processes such as insulin secretion and induction of satiety. EECs are rare cell types \(less than 1% of the epithelium) and produce a large number of different hormones making these challenging to study. Model systems to assess the differentiation and function of these essential cell types have been lacking. In a novel approach, we describe the induction of human EECs in intestinal organoids. Moreover, in the manuscript linked to this protocol, we describe that manipulating the BMP signaling pathway allows to induce expression of specific sets of hormones that correspond to the EEC state in the crypt-villus axis. This differentiation platform can be used to study the function of EECs and could contribute to the development of drugs for diabetes and obesity.
Health anxiety and attentional bias toward virus-related stimuli during the COVID-19 pandemic
Authors: Cannito Loreta , Crosta Adolfo Di , Palumbo Rocco , Ceccato Irene , Anzani Stefano , Malva Pasquale La , Palumbo Riccardo , Domenico Alberto Di
Published: November 2020

After the COVID-19 worldwide spread, evidence suggested a vast diffusion of negative consequences on people's mental health. Together with depression and sleep difficulties, anxiety symptoms seem to be the most diffused clinical outcome. The current contribution aimed to examine attentional bias for virus-related stimuli in people varying in their degree of health anxiety (HA). Consistent with previous literature, it was hypothesized that higher HA would predict attentional bias, tested using a visual dot-probe task, to virus-related stimuli. Participants were 132 Italian individuals that participated in the study during the lockdown phase in Italy. Results indicated that the HA level predicts attentional bias toward virus-related objects. This relationship is double mediated by the belief of contagion and by the consequences of contagion as assessed through a recent questionnaire developed to measure the fear for COVID-19. These findings, indicative of attentional bias for virus-related cues, are discussed in the context of cognitive-behavioral conceptualizations of anxiety suggesting a risk for a loop effect. Future research directions are outlined.
UMI-linked nanopore consensus sequencing (UMIC-seq) of highly similar gene variants
Authors: Zurek Paul Jannis , Knyphausen Philipp , Neufeld Katharina , Pushpanath Ahir , Hollfelder Florian
Published: November 2020

Here we present a straightforward unique molecular identifier (UMI)-linked nanopore consensus sequencing workflow (UMIC-seq), resulting in cost-effective and accurate long-read sequencing of amplicons. Short random molecular barcodes (i.e. unique molecular identifiers, UMIs) are attached to a pool of gene variants prior to nanopore sequencing to enable reliable clustering and the generation of accurate consensus sequences, even when starting from highly similar gene variants (e.g. a library of point mutants in directed protein evolution) that could not be reliably distinguished in the ordinary nanopore sequencing output.
Non-Prescription Antibiotic Use for Cough Among Chinese Children Aged Under 5 Years: A Community-Based Cross-Sectional Study
Authors: Zhu Yao , Luo Shuying , He Hanqing , Yan Rui , Zhou Yang , Deng Xuan , Tang Xuewen
Published: November 2020

Background: Cough is a common symptom in childhood and is an important circumstance of inappropriate antibiotic use. This study aimed to investigate the non-prescription use of antibiotics for cough among children aged under 5 years.Methods: We conducted a community-based survey of under-5 children in Yiwu, China from October to November 2019. The subjects were enrolled from 14 townships using a two-stage stratified sampling procedure. Detailed information was collected through a face-to-face interview based on a standard questionnaire, and the children’s caregivers answered as agents. Univariable and multivariable logistic regression analyses were performed to explore the factors associated with nonprescription use of antibiotics for cough in children. Results: A total of 3102 children were included in the study, and 1211 children were reported to have a cough in the past month. Among them, 40.2% (487/1211) were medicated with antibiotics, and 18.7% (91/487) of these were unprescribed. Cephalosporins were the most frequently used antibiotic (52.8%), and community pharmacies were the main source (53.7%). Children who coughed for 1–2 weeks (OR=1.73, 95% CI=1.03-2.90) or 3–4 weeks (OR=2.39, 95%CI=1.08-4.97), with 2 or more accompanying symptoms (OR=2.44, 95% CI=1.14-5.72), or with a family annual income between 50000 and 100000 RMB (OR=4.14, 95% CI=1.41-17.69) had a higher risk of non-prescription use of antibiotics than those coughing for <1 week, without accompanying symptoms, or with family annual income <50000 RMB.Conclusions: Our findings indicated that a high proportion of infants and young children had been treated with antibiotics for cough, and nearly 1/5 of them were used without prescription. More public health campaigns and further health teaching on the appropriate use of antibiotics are needed to ensure the rational treatment of cough in children.
Prevalence and Management of Dysmenorrhea Among Secondary School Adolescents in Enugu State, Nigeria
Authors: Onu Amaka , Aluh Deborah , Ikehi Michael
Published: November 2020

Background: Dysmenorrhea is reported to be among the most common gynecological disorders worldwide. The current study aimed to determine the prevalence and management practices for dysmenorrhea among adolescent school girls in Nigeria. The study also aimed to determine the predictors for choosing a management option for dysmenorrhea.Methods: The study was a cross-sectional descriptive survey conducted in five conveniently selected secondary schools (high schools) in Enugu State. A 12-item questionnaire including a Visual Analog Scale was used to collect data. All data were analyzed using SPSS with significance set at p<0.05.Results: A total of 1,486 survey questionnaires were completed (88.45% response rate). The mean age of the study respondents was 15.26±1.517. The prevalence of dysmenorrhea was 51.1%. There was a significant difference (t =-6.299, p < 0.001) between the ages of the dysmenorrheic girls (15.50±1.466) and the ages of girls who were not dysmenorrheic (15.01±1.529). The mean age of Menarche was 12.64±1.450. Pain in the waist was the most common symptom reported among the respondents (57.4%, n = 853). More than one-third of the respondents reported that they take OTC medications for menstrual symptoms (31.8%, n = 472). Age and severity of dysmenorrhea significantly predicted the likelihood of taking a pharmacological agent for dysmenorrhea.Conclusion: Younger females were more likely to do nothing about menstrual pain. There is a need for adolescents to be educated on the safety and efficacy of different management options for dysmenorrhea early.
Assessment as Learning in Medical Education: Feasibility and Perceived Impact of Student-Generated Formative Assessments
Authors: Lakhtakia Ritu , Otaki Farah , Zary Nabil
Published: November 2020

Background Self-directed learning is a vital competency, desirable to sustain lifelong competencies in health professions education. Contemporary education practices emphasize this aspect of undergraduate medical education through innovative designs of teaching and learning like the flipped classroom and team-based learning. Assessment as learning can be a unique way to inculcate active learning habits. It charges the student to create formative assessments, reinforcing student-centred deep learning, and critical thinking. This study aims to explore, from a learner perspective, the feasibility and perceived learning impact of student generated formative assessments. Methods The study design employed an educational intervention on a cohort of students in the second year of a six-year undergraduate medical program. The study design involved engaging students' in generating assessments using peer-collaboration, tutor facilitation, and feedback as part of a single course curriculum delivery. The exercise was followed by a mixed methods accrual of student perceptions through surveys. Quantitative survey data was analysed on SPSS. Qualitative inputs underwent thematic analysis. Results Students’ overall score of satisfaction with the educational intervention was 84%. On quantitative analysis, this was strongly correlated with scores for ease and impact on a 5-point Likert scale. The themes that emerged from the qualitative analysis, included: prominent characteristics, immediate gains, and expected long-term benefits of their engagement in preparing the formative assessment. Within the characteristics theme, the following categories emerged: individuals’ engagement, effective interdependencies, novelty, and time requirement. The identified immediate gains included increased motivation, and acquisition of knowledge and skills. As for the expected long-term benefits, they included critical thinking and problem solving, and clinical reasoning. Conclusions As a form of assessment associated learning, student-generated assessments are perceived as viable and constructive, and a stimulating educational exercise by the student-authors. In the short term, the activity constituted for the students a fun, challenging opportunity to deep dive into the content, be creative in designing questions, and improve exam-taking skills. Students expected the long-term effects to include enhancement of critical thinking, and inculcation of student-centred attributes of lifelong learning and peer collaboration, vital to the practice of medicine.
Ibuprofen alters epoxide hydrolase activity and epoxy-oxylipin metabolites associated with different metabolic pathways in murine livers
Authors: Tiwari Shuchita , Yang Jun , Morisseau Christophe , Durbin-Johnson Blythe , Hammock Bruce , Gomes Aldrin
Published: November 2020

Over the last decade oxylipins have become more recognized for their involvement in several diseases. Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen are known to inhibit cyclooxygenase (COX) enzymes, but how NSAIDs affect oxylipins, in addition to COX products, in animal tissues is not well understood. Investigation of oxylipins in livers from male and female mice treated with 100mg/kg/day of ibuprofen for 7 days showed that oxylipins and COX products that were altered by ibuprofen in male livers were 7 times more than in female livers. In male and female livers some prostaglandins were altered, while diols, hydroxy fatty acids and epoxides were only significantly altered in male livers. Some soluble epoxide hydrolase (sEH) products, such as 9,10-DiHODE were found to be decreased, while sEH substrates (such as 9(10)-EpODE) were found to be increased in male livers treated with ibuprofen, but not in female livers. The enzymatic activities of sEH and microsomal epoxide hydrolase (mEH) were elevated by ibuprofen in both males and females. Analyzing the influence of sex on the effect of ibuprofen on oxylipins and COX products showed that approximately 27% of oxylipins detected were influenced by sex. The results reveal that ibuprofen disturbs not only the COX pathway, but also the CYP450 and lipoxygenase pathways in male mice, suggesting that ibuprofen is likely to generate sex related differences in biologically active oxylipins. Increased sEH activity is likely to be one of the mechanisms by which ibuprofen alters the CYP450 pathway.
Changes in the Urine Proteome in Patients With Advanced Lung Cancer After Different Drug Treatments
Authors: Zhang Yameng , Heng Ziqi , Wei Jing , Wang Yingyi , Gao Youhe
Published: November 2020

Lung cancer is one of the most threatening diseases to human life and health because of its mortality. How to choose more efficient drugs and the appropriate timing of treatment for patients with advanced lung cancer is still a problem. As the urine proteome can sensitively reflect the pathological or physiological changes of the body, it has the potential to reflect the dynamic changes of the body after drug treatment. To investigate the changes in the urine proteome of patients with advanced lung cancer after different drug treatments, urine samples were collected and analyzed at different time points. The changes in the urine proteome from the pretreatment state were different in each patient, although some of them were treated with the same drugs. The changes in the biological processes reflected by the differential urinary proteins were consistent with the changes in the clinical manifestations of the patients. This study demonstrates that the pathophysiological changes of patients with advanced lung cancer can be reflected by changes in urinary protein after different drug treatments. In addition, the changes in urinary proteins can reflect the different biological processes in patients after the same drug treatment, and the patients’ clinical condition assessment results are consistent with these changes. These findings may provide additional information for clinical treatment.