bluuebunny/crossref_metadata_2025 huggingface dataset:
The Mediating Effect of Digital Literacy and Self-Regulation on the Relationship between Emotional Intelligence and Academic Stress among University Students: A Cross-Sectional Study.
Authors: Ibrahim Rasha Kadri , Sabbah Saher Al , Al-Jarrah Muhammed , Senior John , Almomani Jehad Ali , Darwish Amani , Albannay Faisal
Published: March 2024

Aim: To assess emotional intelligence and academic stress among healthcare students and investigate the mediating role of students’ digital literacy and self-regulation.
Background: Academic stress continues to be a prevalent issue affecting students' well-being and academic achievement in today's challenging educational environment. Furthermore, combining digital literacy and self-regulation enhances emotional intelligence, creating a holistic strategy called "digitally regulated emotional intelligence" to effectively reduce academic stress. This study emphasizes the significance of developing these abilities in educational settings to prepare students for success in a complex and technology-driven world.
Methods: A cross-sectional study was conducted to examine correlations and describe quantitative data. 240 students' data was collected in the 2023-24 academic year from Fatima college of Health sciences. Pearson's correlation coefficient has been applied to assess the associations between variables, and univariate linear regression was employed to investigate the connections between emotional intelligence and pertinent variables. The Hayes Process Model 4 macro was used to study how students' digital literacy and self-regulation mediate the relationship between emotional intelligence and academic stress.
Results: The emotional intelligence level, digital literacy, and self-regulation were high. Furthermore, the academic stress level was moderate. The mediation analysis revealed that the direct effect of emotional intelligence on academic stress in the presence of the mediators was significant (t=3.830*, p<0.001*). Hence, digital literacy partially mediated the relationship between emotional intelligence and academic stress. On the other hand, self-regulation had no mediation effect on the aforementioned relationship.
Conclusion: The study noted significant connections between study attributes, particularly showing the substantial relationship between emotional intelligence and academic stress. Higher emotional intelligence did not consistently reduce stress levels for moderately stressed students, suggesting that other factors may be influencing their stress levels. Furthermore, digital literacy was found to act as a mediator between emotional intelligence and academic stress, suggesting that proficient use of online resources could help reduce stress in students with advanced digital skills. Finally, self-regulation did not act as a mediator in the relationship between emotional intelligence and academic stress.
A Case of the Successful Application of Using a “Device to Remote Transfer of Information from a Drug to the Human body” in the Treatment of Multiple Sclerosis
Authors: Djumaeva Naylya
Published: March 2024

Laser therapy - is a type of physiotherapy based on the use of optical radiation, the source of which is a laser. The average powers of physiotherapeutic lasers are most often in the range of 1-100 mW, and they are used in almost all areas of modern medicine. The mechanism of action of laser therapy has not been entirely determined; however, according to the Spanish World Laser Therapeutic Association, it is recommended to use the optimal energy parameters of low-level laser radiation. We could not find data on using a “device for remote transfer of information from a drug to a human body,” where the light source is a laser device with an extremely low energy level in treating severe neurological disease - multiple sclerosis. This report describes the results of a study using a “device to remote transfer of information from a drug to the human body “ (Russian patent), where a laser with a power of up to 5 mV was used as a light source, and the drugs erythromycin and acyclovir were used to treat a 52-year-old Caucasian female musician with multiple sclerosis(MS). The applied exposure has led to the suppression of the activity of the disease, preventing the growth of neurological manifestations of the disease and reducing the appearance of demyelinating lesions in the patient’s brain with MS.
BiMass: An approximate batch-incremental clustering using mass-based dissimilarity
Authors: Bhattacharjee Panthadeep , Vidyapu Sandeep , Mitra Pinaki
Published: March 2024

Usage of non-incremental clustering algorithms for dynamic data may lead towards issues such as increased consumption of resources, higher latency and greater execution time. To address such bottlenecks, these algorithms need to be transformed into intelligent algorithms capable of processing the continuously changing data. MBSCAN is a robust non-incremental clustering algorithm that leverages the idea of data dependent dissimilarity to find clusters. An incremental version of MBSCAN viz. iMass was designed to handle single point insertions. However, with increase in number of updates, the iMass algorithm gradually loses its efficiency over MBSCAN due to repeated singular insertions on a larger dataset. We propose an alternative approximate incremental extension to MBSCAN known as BiMass (Batch incremental mass-based clustering to overcome such issues. Our BiMass algorithm facilitates addition of points in batch-mode while building the expensive components of MBSCAN incrementally. Experiments on real world and synthetic datasets showed that our BiMass algorithm achieved a maximum efficiency of around 5.77x over MBSCAN and 2.16x over iMass respectively at a cost of about 7.07% and 13.82% mean memory overhead.
Assessment Of Level Of Polychlorinated Biphenyls (PCBs) In Soil And Edible Crops From River Ala Floodplain In Akure
Authors: Abe Taiwo , Aiyesanmi Ademola Festus , Ojonukpe Omotoyosi Blessing
Published: March 2024

Flooding is one significant process that contributes to the movement of soil and sediments with the pollutants present in it along the river bank. With higher velocities of water, flooding can take contamination downstream. The soil, edible crops (rice and vegetables) samples were collected from Ala river floodplain in Ondo State and analyzed for their physico-chemical characteristics and level of Polychlorinated biphenyls present. The concentrations of nineteen (19) polychlorinated biphenyls (PCBs) were analyzed in soils collected at nine different sites along the floodplain and edible crops collected from six of the sites/ location using Gas Chromatography Mass Spectrometer (GC-MS) to determine the level of contamination of the floodplain and potential risks to the ecosystem and humans. The Ʃ-19 PCB concentrations in the floodplain soils varied between not detected (nd) -60 µg kg −1, n.d – 60 µg kg −1 in vegetables and not detected to 80 µg kg −1 in rice across different locations. Higher concentration values were recorded in rice which suggests plants uptake and bioaccumulation potentials.The concentration of di to tetra homologues are more predominant in the samples. The concentration is lower than the value of permissible limit 2mg kg-1 recommended by Canadian Soil Quality Guideline (CSQG) and United States Environmental Protection Agency (US EPA). Dioxin-like PCBs were not detected
Efficiency in Language Understanding and Generation: An Evaluation of Four Open-Source Large Language Models
Authors: Wong Siu Ming , Leung Ho , Wong Ka Yan
Published: March 2024

This study provides a comprehensive evaluation of the efficiency of Large Language Models (LLMs) in performing diverse language understanding and generation tasks. Through a systematic comparison of open-source models including GPT-Neo, Bloom, FLAN-T5, and Mistral-7B, the research explores their performance across widely recognized benchmarks such as GLUE, SuperGLUE, LAMBADA, and SQuAD. Our findings reveal significant variations in model accuracy, computational efficiency, scalability, and adaptability, underscoring the influence of model architecture and training paradigms on performance outcomes. The study identifies key factors contributing to the models' efficiency and offers insights into potential optimization strategies for enhancing their applicability in real-world NLP applications. By highlighting the strengths and limitations of current LLMs, this research contributes to the ongoing development of more effective, efficient, and adaptable language models, paving the way for future advancements in the field of natural language processing.
Post-Traumatic Growth in Survivors within a Close Radius to the Epicenter of the Beirut Blast
Authors: Chabbouh Alfred , Fahd Ghina , Chahoud Michele , Haddad Ramzi , Naja Wadih
Published: March 2024

Objectives: On August 4th, 2020, one of the biggest ammonium nitrate explosions took place in Beirut. This study is the first of its kind to examine post-traumatic growth and its relation to post-traumatic stress disorder after 6 months of the Beirut Blast.
Methods: This study targeted survivors defined as adults who were in areas affected by infrastructural damage at the time of the blast (within a 4.1 km radius from the epicenter). A total of 322 participants were recruited. Validated Arabic versions of the Post-Traumatic Growth Inventory (Short Form), Patient Health Questionnaire-9, and Post-Traumatic Stress Disorder Checklist Civilian version were employed.
Results: Of the participants, 75.8% had post-traumatic stress disorder and 79.8% had depression. Almost all survivors showed a degree of growth. Individuals with PTSD had 6 PTG degrees higher compared to the group without PTSD. Appreciation for life was the highest-scored PTG domain. There was no association between PTG and depression. Almost 5 degrees of higher PTG was seen in females, participants who had no children, and those who were <1.6 km at the time of the blast.
Discussion: Our findings are consistent with available literature on other disasters around the world. Unlike resilience, PTG is highly related to the development of PTSD. Possible common underpinnings for the development of PTSD and PTG are discussed. PTG may be a useful target for psychotherapeutic approaches.
Conclusion: Beirut blast survivors have an extremely high burden of psychiatric disorders that were left unaddressed after 6 months of the event. While most people had a degree of post-traumatic growth, this was especially higher in those with PTSD. Future efforts should focus on the clinical and social implications of PTG in Lebanon.
The Intraclass Correlation Coefficient as a Measure of Educational Inequality: An Empirical Study with Data from PISA 2018
Authors: YARDIM Yasemin , CÜVİTOĞLU Gürkan , AYDIN Burak
Published: March 2024

In this study we utilized data from the Programme for International Student Assessment (PISA) to investigate differences in schools’ average mathematics scores by treating intraclass correlation coefficient (ICC) as a measure of educational inequality. We computed ICCs both with unconditional and conditional multilevel models for 79 PISA 2018 participating countries and meta-analyzed the results. There are two main purposes of this study; to quantify the inequality after controlling for common PISA-variables across countries and try to explain heterogeneity at the country level, to investigate the school differences in Türkiye due to its large ICCs and the authors’ familiarity with its educational system. The results showed that PISA variables that are common across countries reduced the unconditional ICC by 5% to 73%, further at least 50% of the heterogeneity in conditional ICCs was explained by the country level non-PISA variables. The tracking age, cultural differences and Gross Domestic Product variables were particularly important to explain differences in conditional ICCs. The Türkiye specific model, consistent with the meta-analysis results, indicated that the school type is a substantial predictor to understand ICC. Overall, we briefly explained the important variables that might be helpful to investigate ICC for researchers, administrators and policy makers who are interested in studying educational inequality from a quantitative perspective.
Inference of the Paramentes of a Bioreactor via Approximate Bayesian Evidence
Authors: Farias Filipe , Cruz Davi , Mulas Michela
Published: March 2024

In the context of the recent water crisis, the development and improvement of technologies for efficiently treating wastewater becomes increasingly necessary. Aligned with this, the activated sludge process is widely used in biological wastewater treatment plants to remove carbon and nutrients from wastewater. Although significant advancements have been achieved in recent years in modelling these processes to improve their performance and energy efficiency, the models are still complex and difficult to calibrate using data from real plants. In this work, we use Bayesian inference frameworks to estimate the parameters of the activated sludge process. We employ Gaussian processes to estimate the solution to the differential equations of the activated sludge process model and we fit this estimation to manufactured data of the observations of the wastewater. We find that the use of the Bayesian inference framework outperforms the classical approach in scenarios where measurements are more strongly affected by noise.
Apuntes sobre acumulación de capital y neoextractivismo en América Latina
Authors: De Souza Costa Vítor
Published: March 2024

El objetivo de este artículo es de hacer una discusión sobre las relaciones estructurales que determinan la reproducción del extractivismo como matriz productiva de la cadena global de acumulación y que asocia a América Latina en la posición histórica de región proveedora de materias primas manteniéndola presa en relaciones coloniales. En línea con esa idea, se presenta el concepto y los impactos del extractivismo, tomando en consideración las contradicciones del período del “consenso de los commodities".
Application of machine learning and statistical approaches for optimization of heavy metals (Cd2+, Pb2+, Cu2+, and Zn2+) adsorption onto carbonized char prepared from PET plastic bottle waste
Authors: Chakraborty Tapos Kumar , Rahman Md. Sozibur , Islam Khandakar Rashedul , Nice Md. Simoon , Netema Baytune Nahar , Zaman Samina , Ghosh Gopal Chandra , Rayhan Md Abu , Khan Md. Jahed Hassan , Munna Asadullah , Haque Md. Muhaiminul , Bosu Himel , Hossain Nazmul , Halder Monishanker , Khan Abu Shamim
Published: March 2024

This study focuses on the probable use of carbonized char prepared from PET plastic bottles for heavy metals (HMs) adsorption (Cd2+, Pb2+, Cu2+, and Zn2+). The prepared adsorbent is characterized by field-emission scanning electron microscopy (FE-SEM), energy dispersive X-ray spectroscopy (EDX), and Fourier-transform infrared spectroscopy (FTIR). Batch adsorption experiments were conducted with the influencing of different operational conditions: contact time (1–180 min), adsorbate concentration (25–300 mg/L), adsorbent dose (0.5–6 g/L), pH (3–7), and temperature (25–60 ºC). High coefficient value [Cd2+ (R2 = 0.99), Pb2+ (R2 = 0.97), Cu2+ (R2 = 0.94), and Zn2+ (R2 = 0.98)] of process optimization model suggest that this model was significant, where pH and adsorbent dose expressively stimulus removal efficiency including 86.68, 73.66, 67.10, and 57.04% for Cd2+, Pb2+, Cu2+, and Zn2+ at pH (7), respectively. Furthermore, ANN and BB-RSM revealed a good association between the tested and projected values. The maximum monolayer adsorption capacity of Cd2+, Pb2+, Cu2+, and Zn2+ was 263.157, 78.740, 196.078, and 84.745 mg/g, respectively. Pseudo-second-order was the well-suited kinetics, where Langmuir and Freundlich isotherm could explain better for equilibrium adsorption data. Thermodynamic study shows HMs adsorption is favorable, exothermic, and spontaneous.
Evaluation of Urinary Interleukin-18 Changes in Patients Treated with
Vancomycin
Authors: Azarfar Anoush , Ravanshad Yalda , Ataei Nakhaei Alireza , Mirfendereski Kimia , Kheirabadi Toktam
Published: March 2024

Background:

Vancomycin, used to treat severe gram-positive infections, can induce acute kidney injury. Some evidence introduced Interleukin-18 (IL-18) as an
inflammatory mediator of ischemic damage to many organs and urinary IL-18 as a diagnostic biomarker of acute tubular necrosis.

Objective:

The current study aimed to evaluate the urinary level of IL-18 after vancomycin therapy.

Methods:

This cross-sectional study was conducted on patients under treatment with vancomycin selected from those referred to Dr. Sheikh Hospital,
Mashhad, Iran, from 2018-2019. Urinary IL-18 was measured based on nanograms per milliliter using a human IL-18 enzyme-linked
immunosorbent assay kit about this cytokine before vancomycin administration and then two days later. All the analyses were performed in SPSS
software (version 25), and a P-value less than 0.05 was considered statistically significant.

Results:

A total of 36 patients with a mean age of 40.06±36.67 months were included in the study. The mean scores of IL-18 before and after taking
vancomycin were 1453.00±555.01 and 1713.00±660.98, respectively. The IL-18 was significantly lower before vancomycin consumption than the
level reported after 48 h (P<0.05).

Conclusions:

The present study highlighted a higher level of urinary IL-18 after vancomycin treatment, which may indicate kidney injuries. Therefore, it may be
considered a potential biomarker of acute tubular necrosis in patients under vancomycin therapy.
A Snapshot of Selenium-enclosed Nanoparticles for the Management of Cancer
Authors: Deshmukh Rohitas , Singh Rajesh , Sharma Sandeep , Mishra Ashwini Kumar , Harwansh Ranjit Kumar
Published: March 2024

Among the primary causes of mortality in today's world is cancer. Many drugs are employed to
give lengthy and severe chemotherapy and radiation therapy, like nitrosoureas (Cisplatin, Oxaliplatin), Antimetabolites
(5-fluorouracil, Methotrexate), Topoisomerase inhibitors (Etoposide), Mitotic inhibitors (Doxorubicin);
such treatment is associated with significant adverse effects. Antitumor antibiotics have side effects similar
to chemotherapy and radiotherapy. Selenium (Se) is an essential trace element for humans and animals,
and additional Se supplementation is required, particularly for individuals deficient in Se. Due to its unique features
and high bioactivities, selenium nanoparticles (SeNPs), which act as a supplement to counter Se deficiency,
have recently gained worldwide attention. This study presented a safer and more economical way of preparing
stable SeNPs. The researcher has assessed the antiproliferative efficiency of SeNPs-based paclitaxel delivery
systems against tumor cells in vitro with relevant mechanistic visualization. SeNPs stabilized by Pluronic
F-127 were synthesized and studied. The significant properties and biological activities of PTX-loaded SeNPs
on cancer cells from the lungs, breasts, cervical, and colons. In one study, SeNPs were formulated using chitosan
(CTS) polymer and then incorporated into CTS/citrate gel, resulting in a SeNPs-loaded chitosan/citrate
complex; in another study, CTS was used in the synthesis of SeNPs and then situated into CTS/citrate gel, resulting
in Se loaded nanoparticles. These formulations were found to be more successful in cancer treatment.
Rare Metastatic Embryonal Carcinoma Resembling Lymphoma: A Case Report
Authors: Li Chunying , Ji Xin , Luan Jinwei , Du Juntong , Zhou Yang , Wang Xinxin , Zhang Ying , Guo Sainan , Li Jiaqi , Li Xianglan
Published: March 2024

Background:

Embryonal carcinoma is a rare tissue type in germ cell tumors. According to our literature review, metastatic embryonal carcinoma misdiagnosed
as lymphoma because of its high similarity to lymphoma is extremely rare and has not been reported yet.

Case Presentation:

A 46-year-old middle adulthood male presented with unexplained fever, night sweats, abdominal distension for 3 months, and weight loss of
around 7kg during almost 6 months, which is extremely similar to lymphoma from the clinical features and imaging examinations. After a clear
diagnosis, the case not only obtained the opportunity of surgery but was also exempted from radiotherapy. The treatment effect was good. We
report a case of rare metastatic embryonal carcinoma, which can provide insight into the diagnosis and treatment of embryonal carcinoma.

Conclusion:

Metastatic embryonal carcinoma of abdominal lymph nodes can be highly similar to lymphoma; the diagnosis can only be based on clinical
manifestations and imaging examination but also combined with patient history, tumor markers and biochemical examination. However, the final
diagnosis depends on pathological biopsy.
Observatorio del sistema nacional de ciencia y tecnología agroindustrial :análisis de producto uchuva
Authors: Contreras Carlos Alberto , Flórez Martínez Diego Hernando
Published: March 2024

Según la Organización de las Naciones Unidas para la Alimentación y la Agricultura FAO (2006), la uchuva es una fruta exótica que se origina en Perú y es familiar de las Solanáceas y tiene aproximadamente 80 variedades. Esta fruta exótica no solamente se produce en el país latino americano mencionado previamente sino también en los altiplanos de naciones tropicales y subtropicales como Colombia, Costa Rica, Zimbawe, entre otros. Por lo tanto, estos países productores de la uchuva, han logrado notar el potencial que tiene esta fruta en mercados internacionales como en los países europeos
Evaluation of thermal comfort of dairy cows in silvopastoral and monoculture systems of Boyacá
Authors: Zúñiga Aldemar
Published: March 2024

Silvopastoral systems are an alternative to monoculture system for improve the sustainable production of dairy systems in Colombia. These systems provide bene ts for animals such as the availability of shade, greater diversity in food supply and environmental enrichment. The present study evaluated the thermal comfort of Holstein cows in silvopastoral (SSP) and monoculture (M) systems
Validation and Refinement of the Sense of Coherence Scale for a French Population: Observational Study
Authors: Sebo Paul , Tudrej Benoit , Bernard Augustin , Delaunay Bruno , Dupuy Alexandra , Malavergne Claire , Maisonneuve Hubert
Published: March 2024

Background

Salutogenesis focuses on understanding the factors that contribute to positive health outcomes. At the core of the model lies the sense of coherence (SOC), which plays a crucial role in promoting well-being and resilience.

Objective

Using the validscale Stata command, we aimed to assess the psychometric properties of the French version of the 3-dimension 13-item SOC questionnaire (SOC-13), encompassing the comprehensibility, manageability, and meaningfulness dimensions. We also aimed to determine if a refined scale, assessed through this method, exhibits superior psychometric properties compared to the SOC-13.

Methods

A sample of 880 consecutive primary care patients recruited from 35 French practices were asked to complete the SOC-13. We tested for internal consistency and scalability using the Cronbach α and Loevinger H coefficients, respectively, and we tested for construct validity using confirmatory factor analysis and goodness-of-fit indices (root mean square error of approximation [RMSEA] and comparative fit index [CFI]).

Results

Of the 880 eligible patients, 804 (91.4%) agreed to participate (n=527, 65.6% women; median age 51 years). Cronbach α and Loevinger H coefficients for the SOC-13 were all <0.70 and <0.30, respectively, indicating poor internal consistency and poor scalability (0.64 and 0.29 for comprehensibility, 0.56 and 0.26 for manageability, and 0.46 and 0.17 for meaningfulness, respectively). The RMSEA and CFI were >0.06 (0.09) and <0.90 (0.83), respectively, indicating a poor fit. By contrast, the psychometric properties of a unidimensional 8-item version of the SOC questionnaire (SOC-8) were excellent (Cronbach α=0.82, Loevinger H=0.38, RMSEA=0.05, and CFI=0.97).

Conclusions

The psychometric properties of the 3-dimension SOC-13 were poor, unlike the unidimensional SOC-8. A questionnaire built only with these 8 items could be a good candidate to measure the SOC. However, further validation studies are needed before recommending its use in research.
Towards the Systematic Development of Marketing Students’ Creativity
Authors: Lesser Jack A. , Williams Denise E.
Published: March 2024

Many university marketing students feel uncomfortable about developing creative thinking skills during college. However, they will soon graduate and face a need to utilize their creative abilities and contribute to their organizations. Therefore, this article provides a wide range of strategies to develop students’ creative abilities in marketing classes. It uses Gagné’s classical Nine Instructional Events (i.e., Gagné et al., 2005) to develop the strategies because Gagné systematically and comprehensively examines how to develop effective instructional stages across the entire learning process. The article also focuses on developing specific strategies to help students build creative competencies for very different teaching modes, such as asynchronous and synchronous online, HyFlex, and conventional face-to-face classes. By developing strategies for different modes, the instructor will be able to have comparative insight into how to adjust marketing courses to maximally stimulate students’ creativity, regardless of the type of course.
MOLECULAR DOCKING OF THE KERUING's (DIPTEROCARPUS) GENUS, SECONDARY METABOLITES OF THE DIPTEROCARPACEAE FAMILY'S AS ANTI-INFLAMMATION AGAINST CYCLOOXYGENASE-2 (COX-2)
Authors: RYANT AGUS ADHE SEPTA , SISWANDONO  , TRESIA BUTAR-BUTAR MARIA ELVINA , TAUFIQURRAHMAN MUH. , FERNANDES ANDRIAN , MAHARANI RIZKI
Published: March 2024

Objective: Kalimantan, Indonesia, has a tropical forest abundant in forest products. One of these products is the Dipterocarp tree, which includes the Keruing genus (Dipterocarpus). Dipterocarpus contains secondary metabolites that may be potential sources for new drug compounds. One of these metabolites has the potential to act as an anti-inflammatory agent. Based on pharmacophore modelling and molecular docking, this study used molecular docking to investigate the inhibitory mechanism and affinity of Dipterocarpus secondary metabolites on the 3N8Y inflammatory receptor.
Methods: The study involved multiple stages, such as preparing and optimizing the structure of the test compounds, constructing a 3D receptor structure of 3N8Y, validating the methodology, and performing energy docking simulations to analyze the interactions. From the study that has been done, the results for the test compounds were evaluated for their MolDockScore, Pharmacokinetic parameters (ADME), and toxicity.
Results: The results revealed that the oligomer resveratrol compound exhibited the lowest MolDockScore value of-104.7400, comparable to natural ligands. In addition to that, this method produces reliable outcomes through pharmacokinetic predictions such as HIA (88.4794%), Caco2 (5.1917 nm/sec), and PPB (100%). Furthermore, the toxicity profile exhibited negative results for mutagenic, non-mutagenic, and carcinogenic tests, including genotoxic and nongenotoxic substances.
Conclusion: The oligomeric resveratrol (3',5',4-trihidroksi-trans-stilben) compounds have potential as anti-inflammatory agents by acting on the 3N8Y receptor, which further needs to be tested in vivo.
DESIGN, FABRICATION, IN VITRO, AND EX-VIVO PERMEATION STUDY OF MICRO-EMULSIFIED HYDROGEL OF FLUCONAZOLE (MHG-FLCZ) USING A CENTRAL COMPOSITE DESIGN (CCD)
Authors: GHOSH SOUMYADIP , BASAK ANKITA , GANGULY DEBGOPAL , POREY ANKITA
Published: March 2024

Objective: The current study's objective was to develop and characterize a micro-hydrogel-based fluconazole (FLCZ) gel. A micro-hydrogel (Mhg) was prepared using different concentrations of Carbopol 940 (CP) and NaCMC using the modified swelling hydrogel method.
Methods: A Preformulation study was performed using FTIR to confirm the drug and polymers were compatible with each other based on the functional group determination. 32 optimization procedures were used to develop formulations based on the response surface methodology. The prepared formulations were evaluated for entrapment efficiency, spreadability, viscosity, and visual examination using binocular microscopy and in vitro drug release using Franz diffusion cells.
Results: The optimized formulation F2 reported entrapment efficiency of 65.09±0.41%, and viscosity of 11100±1.21 cps. The in vitro release of drug for the prepared formulations was performed for 8 h. and the optimized formulation showed better-controlled drug release compared to other formulations. It was observed that the optimized batch, percentage of drug permeability through the skin at 8 h of ex-vivo study shows 84.67±0.67% and in vitro drug release study (93.22%) through Franz diffusion cell, which suggests that the drug (Optimum batch) can easily penetrate through the skin and showed the highest drug release in a stipulated time interval.
Conclusion: The use of an optimized Mhg-FLCZ gel formulation as it has excellent homogeneity, a pH that is close to that of the skin, and suitable thixotropic characteristics relates to that much more convenience than the conventional dosage form. The in vitro and ex-vivo study data proved its suitability as a better alternative to conventional products in the effective treatment of skin infections.
ANTIVIRAL ACTIVITY OF SAUSSUREA LAPPA ETHANOL EXTRACT AGAINST SARS-COV-2: IN VITRO STUDY
Authors: FITRIANINGSIH AVIN AINUR , SANTOSANINGSIH DEWI , DJAJALAKSANA SUSANTHY , KARYONO SETYAWATI SOEHARTO , MUTI'AH ROIHATUL , LUSIDA MARIA INGE , PRAWIRO SUMARNO RETO
Published: March 2024

Objective: The study aims to investigate the antiviral activity of S. lappa against Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2) in vitro.
Methods: The extracts are obtained by ultrasonic-assisted extraction (UAE) with a 96% ethanol solvent. Thin-layer chromatography (TLC) uses n-hexane: ethyl acetate and chloroform: methanol) as mobile phases. The staining outcome is subsequently examined using UV visualizers with a wavelength of 366 nm. To assess the antiviral activity of Vero E6 cells, extracts were employed at doses of 25, 50, 75, and 100 µg/ml, with remdesivir serving as the positive control. Supernatants were collected on days 1, 2, 3, and 6 for qRT-PCR testing with target genes E and ORF1ab. Time-addition experiments were conducted to determine how the extract works as antiviral. Protein expression was tested with Western blots with antibodies S and N SARS-CoV-2.
Results: TLC identifies terpenoid chemicals present in the ethanol extract of S. lappa. The ethanol extract of S. lappa exhibited antiviral effects against SARS-CoV-2, with an inhibitory concentration 50 (IC50) of 40 µg/ml, a cytotoxic concentration 50 (CC50) of 131.4 µg/ml, and a selectivity index of 3.51. The extract can potentially impact the entry-post-entry phase of SARS-CoV-2 infection in Vero cells. The immunoblotting results demonstrated a reduction in the expression of S and N proteins in the treatment group compared to the negative control.
Conclusion: S. lappa ethanol extract has antiviral activity against SARS-CoV-2 based on an in vitro study.
BIOSURFACTANTS: SUSTAINABLE ALTERNATIVE TO SYNTHETIC SURFACTANTS AND THEIR APPLICATIONS
Authors: POOMALAI PRAVEENA , KRISHNAN JANESHA , RAVICHANDRAN ASHWIN , SURESHKUMAR RAMAN
Published: March 2024

Biosurfactants are surface active agents produced by microorganisms, which help reduce surface or interfacial tension between two immiscible liquids like oil and water. In recent years, Due to their environmentally friendly nature and wide range of applications in various industries, they can act as a sustainable alternative to synthetic surfactants. This review article provides an overview of biosurfactants, emphasizing their need for biosurfactants, the production process, and their classification based on molecular weight, charge, and the microorganism they derived. The advantages include biodegradability, biocompatibility, low toxicity, surface activity, and specificity, and various areas where the biosurfactant used are emulsification, thermal stability, pH stability, wetting ability, foaming ability, and spreadability. Research on using biosurfactants in various formulations like nanoparticles, liposomes, transdermal application, nanoemulsion, and nanocapsules is also highlighted in this review to support its application in the medical field. Biosurfactants are also utilized in various fields like the pharmaceuticals, cosmetics, food, and oil industries. However, they have their drawbacks, which include high production costs, variability in production yield, sensitivity to the environment, lack of standardization, hurdles in regulatory approval, and research and development limitations. Despite certain drawbacks, biosurfactant offers a sustainable alternative to synthetic surfactants.
Ethical Deliberations in Poetry Over the Ages
Authors: Mohiuddin GH , Sharma Dr Anurag
Published: March 2024

Poetry is a potent medium to communicate ideas and feelings alike. Based on selective use of words along with diverse figures of speech, poetry transmits an idea, a principle or a thought in an impressive way. Poetry is a form of creative writing that uses language to evoke emotions, ideas, and experiences in a concentrated and imaginative way. Poetry has been a powerful medium for expressing and exploring complex ideas and emotions. Poetry and ethics are mutually intertwined and related things. Right from ancient Greeks up-to the present day poets, ethical deliberations have always found a prominent place in the poetry of almost all ages. The present paper is an attempt to highlight how poetry has played its essential role in strengthening the bond between poetry and ethics in different periods and in different ages.
“El libro y la edición digitales: lenguajes y narrativas para el futuro”. Panorama histórico del libro y la edición digital
Authors: García Santos Saraí
Published: March 2024

Reseña de Panorama histórico del libro y la edición digital. Fernando Cruz Quintana. Guadalajara, Jalisco; Colombia; Córdoba, Argentina; Chile: Universidad de Guadalajara / Universidad de los Andes, Ediciones Uniandes / Universidad Nacional de Villa María / Pontificia Universidad Católica de Chile, 2022, 151 p. ISBN: 9786075715964.
Object Detection Using Image Processing For Blind Persons: A Review
Authors: Gandhi Aditya
Published: March 2024

Abstract: The fundamental idea of detection of objects for videos is confirming an object's existence in a series of images and maybe pinpointing it specifically for identification. Monitoring an item's existence, location, size, form, and other physical and Changes in time throughout a video sequence is known as object tracking. The challenge of reproducing the designated area in consecutive frames of a set of photographs captured at closely spaced time intervals is referred to as the temporal correspondence problem. and it must be solved in order to do this. The two processes in question are interrelated. The foundation of tracking is detection, which often begins with the detection of objects. To aid and validate tracking, it is frequently required to identify an item repeatedly in a following image sequence. In light of this, the present review describes how object recognition using image processing might assist the blind.
Augmented Zagreb Index of Corona Product of Some Special Graphs
Authors: Litta E. , Narmadha S.
Published: March 2024

Abstract: Let GV, E be a simple undirected graph. The Augmented Zagreb Index of a graph G is defined as     3 2            uv E G du dv du dv AZI G , Where du is the degree of the vertex u in G . In this paper, the exact expression for Augmented Zagreb Index of different product of graphs like Comb, Wheel, Fan,andSun graph.
Red REMARCO: ciencia y comunicación en el abordaje de estresores marino-costeros
Authors: Brenes-Alfaro Laura , Carrasco-Palma Daniel
Published: March 2024

Este artículo presenta la experiencia de trabajo colaborativo e interdisciplinario entre científicos y comunicadores, en el marco de la Red de Investigación de Estresores Marinos — Costeros en Latinoamérica y el Caribe (REMARCO), creada en el año 2018. Se reflexiona acerca de las acciones logradas desde su creación, y la dinámica establecida entre el grupo científico y el de comunicación. Se concluye que el trabajo colaborativo ha permitido que los científicos aprendan a realizar divulgación de los resultados de sus investigaciones, mientras los comunicadores adquieren conocimientos técnicos sobre la problemática de los estresores marino-costeros, logrando sinergias en beneficio de la divulgación científica; con puntos de mejora que deberán ser solventados en el futuro próximo.
A FRAMEWORK TO IMPROVE THE IMPLEMENTATION OF BUSINESS ETHICS IN ISLAMIC BUSINESS ORGANISATIONS
Authors: Nugraheni Peni , Musa Alhabshi Syed , Rosman Romzie
Published: March 2024

This paper attempts to conduct a review of ethics in Islamic business entities by providing a conceptual framework of Islamic ethical values which is linked to the triple bottom line. This study uses a qualitative descriptive method to discuss these values based on the literature on Islamic ethics and Islamic business ethics. While some ethical values may be implemented similarly in both conventional and Islamic organisations, from the Islamic perspective, the spirit, process, and result become one single unit that must not violate Islamic principles. Humans are not judged solely by the result achieved but also by the process and effort (ikhtiyar). None of our activities should thus occur at the expense of other mahluq. The ability to measure the conformity of a company’s business activities with Islamic business ethics will show the extent to which it has implemented Islamic principles and affirm the organisation’s identity.

Abstrak: Paper ini mencoba melakukan tinjauan terhadap etika pada entitas bisnis syariah dengan memberikan kerangka konseptual nilai-nilai etika Islam yang terkait dengan triple bottom line. Penelitian ini menggunakan metode deskriptif kualitatif yang membahas nilai-nilai tersebut berdasarkan literatur etika Islam dan etika bisnis Islam. Meskipun beberapa nilai etika dapat diterapkan secara umum baik dalam lembaga konvensional maupun Lembaga syariah, namun dalam perspektif Islam, semangat, proses, dan hasil menjadi satu kesatuan yang tidak boleh melanggar prinsip-prinsip Islam. Manusia tidak dinilai hanya dari hasil yang dicapai tetapi juga dari proses dan usahanya (ikhtiyar). Oleh karena itu, tidak boleh ada aktivitas kita yang mengorbankan mahluq lain. Kemampuan mengukur kesesuaian kegiatan bisnis perusahaan dengan etika bisnis Islam akan menunjukkan sejauh mana perusahaan telah menerapkan prinsip-prinsip Islam dan menegaskan identitas organisasi.

Kata Kunci: Etika Bisnis Islam, Organisasi Bisnis Islam, Nilai-Nilai Etika, Triple Bottom Line
Predicting the potential distribution of 12 threatened medicinal plants on the Qinghai-Tibet Plateau (QTP), with a maximum entropy model
Authors: Lucun Yang , Zhu Xiaofeng , Song Wenzhu , Shi Xingping , Hang Xiaotao
Published: March 2024

Climate change is a vital driver of biodiversity patterns and species
distributions, understanding how organisms respond to climate change
will shed light on the conservation of endangered species. In this
study, the MaxEnt model was used to predict the potential suitable area
of 12 threatened medicinal plants in the QTP (Qinghai-Tibet Plateau)
under the current and future (2050s, 2070s) three climate scenarios
(RCP2.6, RCP4.5, RCP8.5). The results showed that the climatically
suitable habitats for the threatened medicinal plants were primarily
found in the eastern, southeast, southern and some part of the central
regions on the QTP. Moreover, 25% of the threatened medicinal plants
would have reduced suitable habitat areas within the next 30-50 years in
the different future global warming scenario. Among these medicinal
plants, FP (Fritillaria przewalskii) would miss the most habitat
(97.1%), while the RAN (Rhododendron anthopogonoides) would miss the
least habitat (0.30%). Nevertheless, 41.6% of the threatened medicinal
plants showed an increase in their future habitat area because of their
physiological characteristics which are more adaptable to a wide range
of climate. The climatic suitable habitat for 50% of the threatened
medicinal plants would migrate to higher altitudes or higher latitudes
regions. This study provides a data foundation for the conservation of
biodiversity and wild medicinal plants on the QTP.
Harbour porpoises respond to small boats by speeding up and moving away
Authors: Hao Xiuqing , Hamel Héloïse , Grandjean Céline , Fedutin Ivan , Wahlberg Magnus , Frankish Caitlin , Nabe-Nielsen Jacob
Published: March 2024

Recreational boats are common in many coastal waters, yet their effects
on cetaceans and other sensitive marine species remain poorly
understood. To address this knowledge gap, we used drone videos to
quantify how harbour porpoises (Phocoena phocoena) responded to a small
motorboat approaching at different speeds (10 or 20 knots). The
experiment was carried out in shallow waters near Funen, Denmark (55.51°
N, 10.79° E) between July and September 2022. Porpoises moved further
away from the boat path during approaches at both boat speeds. In
addition, porpoises swam faster when approached at 20 knots but not when
approached at 10 knots, and they had a higher likelihood of moving away
from the boat path when approached at 10 knots but not at 20 knots.
Importantly, the received sound level did not depend on how fast the
boat approached, suggesting that differences in porpoise responses were
related to the speed of the boat’s approach rather than to sound itself.
The porpoises’ behaviour during the minute where the boat was closest
did not differ from their behaviour before boat exposure, indicating
that the direct impact of small vessels on porpoise behaviour was most
likely small. Nevertheless, repeated exposure to noise from small
vessels could influence porpoises’ foraging efforts and cause them to
relocate from disturbed areas. The approach used in this study increases
our understanding of recreational boats’ impact on harbour porpoises and
can be used to inform efficient mitigation measures to help conservation
efforts.
Prevalence of Alternative Lengthening of Telomeres (ALT) in Pediatric Sarcomas Determined by the Telomeric DNA C-circle Assay
Authors: Reynolds C. Patrick , Burrow Trevor A. , Koneru Balakrishna , Macha Shawn J. , Sun Wenyue , Barr Frederic , Triche Timothy
Published: March 2024

Background: Alternative lengthening of telomeres (ALT) occurs
in sarcomas and ALT cancers share common mechanisms of therapy
resistance or sensitivity. Telomeric DNA C-circles are self-primed
circular telomeric repeats detected with a PCR assay that provide a
sensitive and specific biomarker exclusive to ALT cancers. We have
previously shown that 23% of high-risk neuroblastomas are of the ALT
phenotype. Here, we investigate the frequency of ALT in Ewing’s family
sarcoma (EFS), rhabdomyosarcoma (RMS), and osteosarcoma (OS) by
analyzing DNA from fresh frozen primary tumor samples utilizing the
real-time PCR C-circle Assay (CCA). Methods: We reviewed prior
publications on ALT in pediatric sarcomas. DNA was extracted from fresh
frozen primary tumors, fluorometrically quantified, C-circles were
selectively enriched by isothermal rolling cycle amplification and
detected by real-time PCR. Results: The sample cohort consisted
of DNA from 95 EFS, 191 RMS, and 87 OS primary tumors. One EFS and 4 RMS
samples were inevaluable. Using C-circle positive (CC+) cutoffs
previously defined for high-risk neuroblastoma, we observed 0 of 94 EFS,
5 of 187 RMS, and 62 of 87 OS CC+ tumors. Conclusions:
Utilizing the ALT-specific CCA we observed ALT in 0% of EFS, 2.7% of
RMS, and 71% of OS. These data are comparable to prior studies in EFS
and OS using less specific ALT markers. The CCA can provide a robust and
sensitive means of identifying ALT in sarcomas and has potential as a
companion diagnostic for ALT targeted therapeutics.
Multi-Model Deep Learning System for Screening Human Monkeypox Using Skin Images
Authors: Jain Deepak Kumar , Gupta Kapil , Bajaj Varun , Hussain Amir
Published: March 2024

sion dataset. Results: By amalgamating features extracted from
all three CNNs and utilizing the medium Gaussian kernel of the SVM
classifier, our proposed system achieves an outstanding av- erage
classification accuracy of 90.4%. Conclusions: Our developed
MPXCN-Net is suitable for test- ing with a large diversified dataset
before being used in clin- ical settings.
Prokaryotic Expression of a Novel Therapeutic recombinant transbody H2L2 Targeting Hepatitis B Virus core protein
Authors: Li Yanqing , Gao Juanjuan , Wang Bo , Wang Fang , Wang Zhonglin , Liu Bing , Hui Lingyun , Li Yiping , Wang Yawen
Published: March 2024

Background and Purpose Chronic Hepatitis B virus (CHB) infection is a
global burden for public health. Treatment methods such as interferon
and nucleoside analogues may effectively control viral infection but
cannot eliminate the virus due to their inability to remove viral
covalently closed circular DNA (cccDNA) inside host nuclear. The
persistence of cccDNA in the infected hepatocytes is a crucial obstacle
to antiviral therapies. For years, efforts had been undertaken to
understand the formation and regulation of HBV cccDNA. Natural core
antibodies were modified to target intracellular core proteins across
the membrane to achieve antiviral effect in several studies. However,
modified natural antibody had limits: 1) it was unstable inside cells;
2) it had strong immunogenicity; 3) lack of targeting. Experimental
approach and Key Results Therefore, we altered natural antibody into a
micro-transbody which has correct intracellular folding, stronger
affinity, and weaker immunogenicity to establish a new recombinant
transbody for the specific and efficient immune clearance of viruses in
hepatocytes. Immunofluorescence and immunohistochemistry were used to
verify the transmembrane and antigen-binding ability of our recombinant
transbody. Conclusions & Implications Taken together, we demonstrate a
recombinant transbody H2L2 with transmembrane and antigen-binding
activity expressed by E.coli in this study, which may be an encouraging
exploration of therapeutic strategies against hepatitis B infection
inside hepatocellular.