bluuebunny/crossref_metadata_2025 huggingface dataset:
СИСТЕМА УПРАВЛІННЯ ЯКІСТЮ ОСВІТИ У СПЕЦІАЛЬНОМУ НАВЧАЛЬНОМУ ЗАКЛАДІ
Authors: Іщук Валентина
Published: May 2023

Автор розкриває значення якості спеціальної освіти, зокрема,управління якістю освіти, виявляє протиріччя і труднощі в реалізації цієї мети. Авторомзазначено, що професійна управлінська компетентність керівника спеціальних закладівзагальної середньої освіти являється складним структурним утворенням. Створеннярівних можливостей для дітей і молоді у здобутті якісної освіти певною мірою залежитьвід стратегії управління сферою освіти на регіональному рівні та підготовки новоїгенерації керівників середніх загальноосвітніх навчальних закладів. У статті зазначенощо якості шкільної освіти та її недостатній рівень у більшості випадків зумовленийнекомпетентністю управлінської діяльності директора закладу освіти, недостатнім рівнемпрофесійної готовності керівників до управління середнім загальноосвітнім навчальнимзакладом, відсутністю системи відбору освітян, потенційно здатних до управлінськоїдіяльності, їхньої підготовки до забезпечення якості шкільної освіти. Автором зазначенощо, якість освіти можна представляти як багатовимірну модель соціальних норм і вимог42до особистості, освітнього середовища, в якому відбувається її розвиток, та системиосвіти, яка реалізує їх на певних етапах навчання людини. Вона є багатогранноюкатегорією, яка за своєю сутністю відображає різні аспекти освітнього процесу –філософські, соціальні, педагогічні, політичні, демографічні, економічні та інші. Однак, узагальній, а особливо в корекційній педагогіці, досліджень, спрямованих на вивченняпитань управління якістю освітою, вкрай недостатньо.Автор робить акцент на тому, що в педагогічній теорії і практиці існують різніпідходи до розуміння термінів «якість освіти» і «управління освітою». Управління якістюосвіти включає чітку структуру, яка має елементи, пов’язані зі здатністю керівникавирішувати певні проблеми в різних сферах, але частіше у професійній діяльності. Також,якість освіти є результатом навчання, що виражається в знанні особистості про певний набірметодів роботи стосовно певної теми впливу.Як висновки визначено, що управління спеціальним навчальним закладом є послідовнимцілеспрямованим процесом, який має циклічний характер і формується через функції −конкретні види управлінської діяльності, які забезпечують формування прийомів, способівуправлінського впливу на освітню сферу. До них відносимо аналіз, планування, організацію,контроль. Виділяють різні підходи до управління якістю освіти. Серед яких мивиокремлюємо: процесуальний, логіко-інформаційний, рефлексивний, синергетичний,системний, інноваційний.
Restructuring in a mesolect: a case study of the formal variation of the infinitive in Ukrainian-Russian «surzhyk»
Authors:   University of Oldenburg (Slavic department), HENTSCHEL Gerd , PALINSKA Olesya ,   University of Oldenburg (Slavic department)
Published: May 2023

Apart from minority languages such as Polish, Bulgarian and some others, the linguistic landscape of modern Ukraine can be characterized as «tricodal»: in addition to the Ukrainian and Russian languages, mixed Ukrainian-Russian speech or «Surzhyk»
Assessing Goodness of Approximate Distributions for Inferences about Parameters in Nonlinear Regression Model
Authors: Karami Md Jamil Hasan
Published: May 2023

It is often crucial to make inferences about parameters of a nonlinear regression model due to a dependency of Fisher information on the parameter being estimated. Here, the distribution of the relevant test statistic is not exact, but approximate. Therefore, similar conclusion, based on the values of different test statistics, may not be reached. This study shows, in this circumstance, how to come up with a nonlinear regression model that can be used for forecasting and other related purposes. The goodness of the approximate distributions, F and χ 2 , has been assessed to reach a correct decision. The simulation results show that the simulated probability of committing a type I error is very close to its true value in case of F distribution corresponding to F statistic. However, the χ 2 distribution does not do a similar job for the LRT statistic since the simulated type I error is quite larger.
Dhaka Univ. J. Sci. 71(1): 13-16, 2023 (Jan)
Optimization of 18F Radioisotope Production with Cyclone 18/9 MeV IBA Cyclotron Installed at NINMAS
Authors: Rabbani AFM Masum , Mia Md Shohag , Mehdi Hasan , Biswasarma Sanchoy Chandra , Islam Md Ariful , Uddin Md Jashim , Biman Tanvir Ahmed , Ul Azim Mohammad Anwar , Hossain Md Nahid
Published: May 2023

A cyclotron is a particle accelerator, which employs electromagnetic fields to accelerate charged particles to extremely high speeds and energy. It is used to create radioisotopes for radiopharmaceuticals, which are used to diagnose and treat cancer. Because cyclotron-produced radiopharmaceuticals are exceptionally effective in identifying various cancers. Cyclotrons are fast evolving and will play an increasingly important role in the healthcare industry, particularly in advanced medical imaging techniques like positron emission tomography-computed tomography (PET-CT) and single photon emission computed tomography (SPECT). An 18/9 MeV cyclotron (18 MeV for proton and 9 MeV for deuteron, Model: Cyclone 18/9, IBA) was installed at the National Institute of Nuclear Medicine and Allied Science (NINMAS), Bangladesh Atomic Energy Commission (BAEC). Radioisotopes such as 18F, 11C, 13N, and 15O can be produced with this cyclotron. Solid target option is also available here which can be used for producing 67Ga, 68Ga, 124I, 123I, 111In, 99mTc, 64Cu, and 89Zr radioisotopes. 18F is the radioisotope of choice for many radiopharmaceuticals due to its glucose analogous and half-life of 110 min. We are producing FDG on a regular basis. For a 60-minute bombardment time, a 40 to 50 micro amp beam current is employed to produce 18F with a mass of 2500 to 3500 mCi. Because of the variable production parameters used, the production of 18F varies. Parameters used in the production of 18F radioisotope are limited to physical factors such as target material, target volume, collimator, stripper foil, and ion source. As a result, we consider 18F yield to be the most important aspect in providing sufficient activity since we want to find the best operating point that minimizes both production time and cost. In order to produce an optimal 18F radioisotope production, all parameters such as dee voltage, vacuum label, beam current, irradiation time, amount of enriched 18O water, target pressure, and others are taken into account.
Dhaka Univ. J. Sci. 71(1): 56-59, 2023 (Jan)
Analyzing Overdispersed Skilled Antenatal Care Visits of Pregnant Women in Bangladesh Using Generalized Poisson Regression Model
Authors: Hossain Akib Md Muddasir , Pal Bikash
Published: May 2023

It is common to use the Poisson regression model (PRM) for analyzing the count data. The major limitation of this PRM is that the mean and variance of the response variable need to be equal. However, in the actual dataset, the response variable’s variance may exceed the mean, introducing overdispersion in the dataset. In this paper, the generalized Poisson regression model (GPRM) has been used in the modeling and analysis of the skilled antenatal care (ANC) count data extracted from the Bangladesh Demographic and Health Survey (BDHS) 2017-18. The findings of this study have revealed several socioeconomic and demographic variables that significantly impact the skilled ANC visits.
Dhaka Univ. J. Sci. 71(1): 69-75, 2023 (Jan)
Uji Kevalidan Dan Keterbacaan Instrumen Tes HOTS Berbasis 3TMC Tema Menjaga Tekanan Darah Untuk Siswa Kelas VIII
Authors: Azzahra Nadiyah , Sjaifuddin Sjaifuddin , Septi Kurniasih
Published: May 2023

Konsep IPA bersifat abstrak sehingga memerlukan pembelajaran kontekstual untuk menumbuhkembangkan kognitif siswa. Salah satu upayanya adalah dengan menerapkan pembelajaran dan penilaian yang mengukur tingkat kemampuan secara utuh, seperti penerapan penilaian diagnostik pada tingkat HOTS. Tujuan penelitian ini adalah untuk mengetahui validitas dan keterbacaan instrumen tes HOTS berbasis 3TMC tema menjaga tekanan darah. Penelitian ini mengacu pada model Thiagarajan yang terdiri dari 3 tahapan yaitu: define, design, dan develop. Instrument tes yang dikembangkan dinilai oleh 2 orang dosen ahli materi, 2 orang dosen ahli evaluasi, 3 orang praktisi, dan 30 siswa kelas VIII SMP. Pengumpulan data menggunakan lembar wawancara, lembar validasi, dan angket keterbacaan. Hasil penilaian menunjukkan bahwa 92,1% instrumen tes berada dalam kategori sangat valid sehingga dapat digunakan sebagai alat evaluasi. Selanjutnya produk direvisi dan direduksi hingga memperoleh persentase keterbacaan 86,5% (kategori sangat baik) yang menunjukkan bahwa produk memuat materi yang dapat dipahami, disajikan secara menarik, ditulis dengan bahasa yang mudah dipahami, serta penyajian tabel dan gambar sudah sesuai.

Kata kunci: Instrumen Tes HOTS; 3TMC; Menjaga Tekanan Darah
Connectivity of Targets for Disaster Risk Reduction and Achievement of Sustainable Development Goals - Case Study: Major Flood in DKI Jakarta 2020
Authors: Subiyanto Adi
Published: May 2023

[Connectivity of Targets for Disaster Risk Reduction and Achievement of Sustainable Development Goals - Case Study: Major Flood in DKI Jakarta 2020]. DKI Jakarta is naturally a flood-prone area, so handling it is not easy to do. Success in handling floods will have a positive impact on development activities, as reflected in low economic losses. The purpose of this study is to review the causes and triggers of major flooding in the DKI Jakarta area in 2020 and seek connectivity between targets in the Sendai Framework for Disaster Risk Reduction (SFDRR) and the Sustainable Development Goals (SDGs). Researchers collect library materials from various sources that are used to analyze research problems, followed by drawing conclusions. The results showed that the causes of flooding in DKI Jakarta were geological, geomorphological, and river morphometric factors, while the La Nina phenomenon triggered major floods in 2020. The 2020 floods resulted in an economic loss of IDR 960 billion from DKI Jakarta's gross domestic product (701.98 trillion), so the proportion is 0.137 percent. In other words, success in reducing the risk of flood disasters can reduce economic losses and has indirectly encouraged the achievement of several other targets in the SDGs.

 Keywords: Floods, La Nina, SFDRR, SDGs, DKI Jakarta
Implementation of the TaRL Approach to Increase Student Learning Motivation in Physics Learning
Authors: Ningrum Melinda Cahya , Juwono Budi , Sucahyo Imam
Published: May 2023

This study aims to increase students' motivation in learning physics by implementing the TaRL (Teaching At The Right Level) approach. This type of research is classroom action research. The research subjects used 1 class X SMA as many as 38 students at SMA Negeri 21 Surabaya. the instruments used were in-class observations and questionnaires on students' learning motivation in learning glasses. The results of the study were that 68.80% of students felt happy during the spectacles learning process with the implementation of the TaRL (Teaching at The Right Level) approach because it was collected according to their respective ability levels and students liked working together in groups to complete the tasks given. From the research that has been carried out, it shows that the TaRL (Teaching at The Right Level) approach can increase students' learning motivation
Perancangan Aplikasi Absensi berbasis Android menggunakan QR-CODE pada Pemerintah desa Panguragan Lor
Authors: Sohirin Sohirin
Published: May 2023

Absensi merupakan suatu kegiatan yang sangat penting di berbagai Bidang, Contohnya kegiatan belajar mengajar, Bidang Industri maupun di Instansi Pemerintahan. di kantor desa Panguragan lor saat ini masih menggunakan sistem tulis tangan untuk melakukan rekap data daftar hadir sehingga kurang bergitu efisien. Selain terkesan jadul di era revolusi industri 4.0 seperti sekarang, metode tersebut masih memiliki kelemahan seperti mudah dimanipulasinya oleh perangkat desa, membutuhkan waktu yang lama untuk melakukakn rekapitulasi daftar hadir, ketidak sesuaian antara jam masuk yang telah disesuaikan dengan jadwal, sering terjadinya perilaku titip absen antar perangkat desa. Oleh karena itu, perlu dibuat sebuah sistem aplikasi absensi berbasis Android di Instansi Pemerintahan desa Panguragan Lor. dalam masalah ini, perancangan aplikasi absensi menggunakan metode Quick Response Code (QR Code), serta menggunakan Google spreadsheet sebagai database. Metode yang digunakan dalaman perancangan sistem ini menggunakan metode Waterfall. Sistem ini juga menggunakan NRPD (Nomor registrasi perangkat desa) sebagai Primary Key yang nanti nya di gunakan oleh perangkat desa untuk Login ke dalam aplikasi, sehingga perangkat desa satu dengan yang lainya memiliki user login yang berbeda beda sehingga bisa mengurangi terjadinya perilaku titip absen. Dengan di bangun nya aplikasi absensi ini agar bisa membantu pemerintah desa Panguragan Lor dalam perekapan persensi, agar lebih efisien dan mengurangi kesalahan dalam input data. Serta, untuk mempermudah pemerintah desa Panguragan Lor dalam mengelola data daftar hadir Perangkat desa.

Kata kunci : android, perangkat desa, absensi, aplikasi.
SISTEM INFORMASI TERINTEGRASI UNTUK MANAJEMEN PERSEDIAAN DAN DISTRIBUSI BARANG PDAM KOTA LANGSA
Authors: Akram Rizalul , Marhamah Marhamah , Novianda Novianda
Published: May 2023

ABSTRAK

Persediaan barang merupakan aset berharga perusahaan yang berperan penting dalam mendukung aktivitas produksi, sehingga di perlukan pengendalian yang optimal. Perusahaan harus mampu mengendalikan persediaan barang agar tidak terlalu besar. PDAM kota langsa merupakan salah satu perusahaan produksi yang bergerak dibidang pengelolaan air yang mempunyai sebuah gudang yang masih mencatat pengambilan barang ATK maupun Teknik kepada supplier secara manual, sehingga pengelolaan barang masih belum terkomputerisasi dengan baik yang mengakibatkan terjadinya perselisihan barang antara pihak gudang PDAM denga setiap kantor unit. Melalui pengendalian persediaan yang optimal, perusahaan dapat meminimalkan barang yang disediakan, tujuan dari penelitian ini adalah untuk mengatur persediaan barang-barang ATK dan teknik yang tersimpan didalam gudang dan digunakan dalam proses pengambilan barang oleh bagian gudang kepada pihak supplier dan pengeluaran barang yang dilakukan oleh kantor unit. Sebelumnya, setiap barang yang dikeluarkan dari kantor pusat PDAM, kantor unit harus membuat kwitansi pengambilan barang terlebih dahulu melihat permasalahan tersebut maka dibuatlah suatu sistem yang mempermudah dalam pengambilan barang. Penelitian ini menggunakan metode integrasi horizontal dimana terdapat dua sistem yang saling terhubung satu dengan lain nya dengan memaparkan bagaimana pengendalian persediaan barang ATK dan teknik

Kata kunci: persediaan barang, pengeluaran barang, pengendalian persediaan
Optimasi Penggunaan Data Logger Pada Internal Kendaraan Berbasis IOT
Authors: Roska Edo , Taufiq Taufiq , Rosdiana Rosdiana , Meliala Selamat
Published: May 2023

Abstract―Vehicles are a secondary need for humans that can be postponed. However, Indonesia has a tropical climate, so everyone needs a vehicle as a means of transportation, therefore every year vehicles increase rapidly as the population increases. Indonesia is currently a fairly large vehicle sales market. So with the increasing number of road vehicles getting out of control, the result is congested roads, as a result of which traffic violations and accidents are increasing every year. Therefore, by making an optimization tool for using data loggers on two-wheeled vehicles, we intend to monitor every vehicle on the road. However, this research focuses on output data such as accuracy and delay of real time IoT-based vehicle data and data loggers that are stored automatically on SD memory cards in two-wheeled vehicles. The research results from the Infrared sensor data sent to the Blynk server, there is a fairly long delay and the data stored on the SD memory card is quite good, only has a delay per one second, the voltage sensor here plays a good role in real time data and data on the SD memory card because there is no delay the old ones are in sync with actual events, while the realtime control panel output results to the Blynk server using the NodeMCU ESP8266 produce realtime output, and the use of relays as controllers of the tools that have been made has been tested and obtained satisfactory results.
Implementasi Data Mining Menggunakan Algoritma Apriori Pada Sistem Persediaan Obat Di Puskesmas Banggae II Kabupaten Majene
Authors: Rahman Aulia , Ismail Ismail , Irianti Arnita , Nurmaliana Nurmaliana
Published: May 2023

Puskesmas Banggae II Kabupaten Majene Provinsi Sulawesi Barat saat ini masih memiliki kendala dalam memprediksi kesesuaian stok obat yang dibutuhkan dengan ketersediaan stok yang ada. Hal ini disebabkan sistem pemesanan obat tersebut masih bersifat konvensional dimana pengecekan data persediaan obat dilakukan satu persatu kemudian di rekap dalam sebuah buku lalu dipindahkan kembali ke dalam laporan permohonan obat untuk selanjutnya diajukan ke Gudang Farmasi Majene atau Dinas Kesehatan Majene untuk dilakukan permintaan obat. Proses Data Mining menggunakan Algoritma Apriori ini di implementasikan menggunakan data transaksi obat pada Apotek Puskesmas Banggae II. Penelitian ini bertujuan untuk menemukan kecenderungan pola kombinasi pembelian obat atau produk. Hasil dari sistem tersebut dapat dijadikan sebagai informasi dalam pengambilan keputusan untuk mempersiapkan stok obat apa yang kosong dan harus diperhatikan ketersediananya dan obat apa yang kerap dibutuhkan oleh pasien. Algoritma apriori ini menggunakan nilai minimum support dan minimum confidence untuk jumlah frekuensi itemset dan rule yang akan dihasilkan. Output dari sistem ini dapat menemukan kecenderungan pola kombinasi pembelian obat yang kerap di lakukan dan dibutuhkan oleh pasien. Dengan adanya sistem ini diharapkan dapat menjadi rujukan pengambilan keputusan terkait stock obat yang harus tersedia sehingga tidak mengganggu pelayanan kesehatan di Puskesmas Banggae II Kabupaten Majene.
Rancang Bangun dan Implementasi Aplikasi Internal Meeting
Authors: Hamdana Elok
Published: May 2023

Rapat merupakan bagian dari kegiatan penting dalam sebuah instansi untuk menyusun rencana kerja. Hal yang harus dipersiapkan dalam kegiatan rapat adalah membuat agenda rapat dan membuat notulensi rapat. Tetapi dalam pendistribusian terdapat permasalahan yaitu tidak terintegrasinya data dan informasi rapat menyebabkan kurang efisiennya manajemen peserta, penjadwalan rapat dan dokumentasi rapat yang telah dilaksanakan. Aplikasi internal meeting merupakan salah satu solusi yang efektif dan efisien untuk mengatasi keterbatasan dalam permasalahan yang terdapat pada manajemen rapat yang masih dilakukan secara manual. Aplikasi internal meeting ini dapat diakses dimanapun dan kapanpun melalui website. Proses pendistribusian undangan kepada peserta dikirimkan melalui email. Peserta dapat masuk ke dalam sistem untuk mengetahui agenda rapat, melakukan absensi dan mengetahui hasil rapat yang dituliskan oleh notulen. Pengembangan aplikasi menggunakan metode waterfall dengan menggunakan framework PHP yaitu codeigniter dengan menggunakan database MySQL. Pengujian validasi menggunakan metode black box dengan tingkat keberhasilan 100% valid. Sedangkan hasil pengujian compatibilty didapatkan hasil yang compatible menunjukkan sistem bisa berjalan dengan baik di berbagai web browser dan hasil persentase pengujian usability adalah 78.75%, artinya sistem dalam kategori sangat layak. Sehingga dapat disimpulkan hasil aplikasi internal meeting berbasis website yang dapat digunakan untuk mengelola agenda rapat, undangan rapat serta mendokumentasikan hasil rapat yang akurat dan tepat di Diskominfo Kota Kediri serta berbasis android yang dapat digunakan oleh peserta untuk mengakses feture meeting dapat berjalan dengan baik.
Penerapan Teknologi Sistem Pakar Dengan Metode Teorema Bayes Untuk Deteksi Dini Penyakit Parkinson
Authors: Irmansyah Lubis Ahmadi , Sartikha Sartikha , Ardi Noper
Published: May 2023

Penyakit Parkinson merupakan salah satu dari serangkaian jenis penyakit dengan angka kematian yang cukup tinggi dengan jumlah kematian sampai pada jumlah jutaan nyawa di seluruh dunia setiap tahunnya. Angka kematian tersebut cenderung meningkat karena kurangnya informasi tentang gejala awal dan bahaya dari penyakit parkinson itu sendiri, sehingga diperlukan suatu sistem yang dapat memberikan informasi tentang penyakit parkinson dan cara penanggulangannya karena kurangnya informasi deteksi dini. penyakit Parkinson menggunakannya. Masalah ini dapat diatasi dengan teknik berbasis sistem pakar, yang dapat melakukan deteksi berdasarkan gejala yang dialami pasien. Salah satu pendekatan yang dapat diterapkan pada aplikasi teknis sistem pakar adalah Teorema Bayes, yaitu suatu cara mendefinisikan ukuran kepastian tentang suatu fakta atau aturan yang menggambarkan tingkat kepercayaan yang dimiliki seorang pakar tentang masalah yang dihadapi. Perancangan dan penerapan pendekatan Bayesian pada sistem pakar untuk deteksi dini gejala penyakit Parkinson berjalan dengan baik dan menghasilkan jenis kategori penyakit Parkinson yang dialami oleh pengguna sistem, berdasarkan gejala yang dialami dan gejala yang dipilih oleh pengguna.
Decision Tree for Predicting the Mortality in Hemodialysis Patient with Diabetes
Authors: Ardi Noper , Lubis Ahmadi Irmansyah , Isnayanti Isnayanti
Published: May 2023

Hemodialysis patients with diabetes face a significantly higher risk of mortality compared to those without diabetes. Accurate prediction of mortality in this patient population is crucial for guiding clinical decision-making, improving patient outcomes, and optimizing resource allocation. Hemodialysis is a procedure for cleaning the blood from the waste products of the body's metabolism. this is one of modality to treat end stage kidney disease. Diabetes mellitus is a significant contributor to the global burden of chronic kidney disease (CKD), and patients with diabetes undergoing hemodialysis are at a higher risk of mortality compared to those without diabetes. Identifying factors that influence mortality risk in this population can aid in clinical decision-making and improve patient outcomes. Dialysis is performed on patients with kidney failure, both acute kidney failure and chronic kidney failure. This study is aimed to predict the mortality risk of hemodialysis patients with diabetes. The Taiwanese hemodialysis center enrolled a total of 665 hemodialysis patients. The prediction is based on Decision Tree. Compared with K-Nearest Neighbor, linear discriminant, Logistic Regression, and Ensemble, Decission Tree performed better. As for related medical variables like parathyroid surgery, urea reduction ratio, etc., they play a much smaller role in mortality risk factors than diabetes and cardiovascular disease.

Diabetes
Pengaruh Strategi Deferensiasi Produk, Digital Marketing dan Inovasi Produk terhadap Keunggulan Bersaing Motor Honda Scoppy
Authors: Talambanua Edwin , Nasution Zulkarnain , Harahap Aziddin
Published: May 2023

Penelitian ini dilakukan untuk mengetahui pengaruh strategi deferensiasi produk,  digital marketing dan inovasi produk terhadap Keunggulan Bersaing baik secara simultan maupun maupun secara parsial Motor Merek Honda Scoopy. Penelitian ini dapat digunakan sebagai bahan perbandingan dan referensi dalam melakukan penelitian dengan objek ataupun masalah yang sama dimasa yang akan datang dengan menambah variabel-variabel lainnya, penelitian ini menggunakan metode penelitian Kuantitatif menggunakan data yang bersifat angka-angka dianalisis melalui statistik. Jumlah Sampel dalam penelitian ini adalah sebanyak 79 orang pemilik motor Honda Scoopy. Tekhnik pengumpulan data menggunakan kuisioner kepada responden yang dianggap sesuai dengan penelitian yang akan dilakukan. Data dianalisis menggunakan rumus diantaranya : uji validitas dan realibilitas, uji asumsi klasik, uji analisis regresi berganda, uji f test dan uji t test, uji koefisien determinasi dengan bantuan software SPSS 23. Hasil analisis menunjukkan bahwa variabel strategi deferensiasi produk,  digital marketing dan inovasi produk berpengaruh signifikan secara simultan dan parsial terhadap Keunggulan Bersaing Motor merek Honda Scoopy. Variabel strategi deferensiasi produk,  digital marketing dan inovasi produk memiliki koefisien regresi positif (+) yang menunjukkan suatu hubungan searah, dengan kata lain, strategi deferensiasi produk,  digital marketing dan inovasi produk akan meningkatkan keunggulan Bersaing Motor Merek Honda Scoopy
Perancangan Aplikasi Layanan Nifas “Nanme”
Authors: Suwandy Riche , Halim Fandi , Sherly Sherly
Published: May 2023

Aplikasi layanan nifas “NanMe” merupakan aplikasi yang ditujukan kepada para ibu yang baru memiliki anak pertama memiliki pengalaman yang masih minim dalam perawatan bayi. Selain itu, sebagian ibu belum mampu melakukan aktifitas secara mandiri dalam perawatan bayinya dalam masa nifas. Sehingga membutuhkan perawat nifas yang dapat membantu merawat ibu yang menjalankan masa nifas serta bayinya. Namun, untuk mempekerjakan seorang perawat nifas membutuhkan biaya yang lumayan besar dan tidak dapat dilakukan transaksi tawar-menawar harga. Perawat nifas membutuhkan platform yang menyediakan pelatihan dasar yang dapat meningkatkan kualitas dari jasa yang akan mereka berikan. Atas masalah tersebut, penulis membuat perancangan aplikasi layanan nifas “NanMe” berbasis aplikasi mobile yang memiliki fitur mencari perawat nifas, tawar- menawar harga, serta pelatihan untuk perawat nifas. Dengan aplikasi “NanMe”, masalah sulitnya mencari perawat nifas dapat diminimalisir dan perawat nifas memiliki platform yang menyediakan pelatihan nifas.
Persepsi Mahasiswa MIPA Terhadap Pengelolaan Sampah Padat Berbasis 3R Di Kampus Universitas Islam Malang
Authors: Rohman Ahmad Taufiq , Hayati Ari , Lisminingsih Ratna Djuniwati
Published: May 2023

According to the republic of indonesia no undang-undang 18 years 2008, about waste management waste matter especially in kota-kota throughout the country right now this has been an issue that is always discussed the need to get the attention of all parties, no exception to the environment, poor islamic university campus how students perception about waste management 3r, based how about the model student perception of the trash can exist at community college islamic university, poor how are the awareness of student participation environmental quality to maintain a healthy and clean through waste management 3r, based this research use descriptive quantitative research methods and surveys in a field. directly A survey is data collection techniques specific techniques, than the other the percentage of perception student who answered a questionnaire in rata-rata show high marks, Student perception about waste management 3r based in college islamic university shows poor perception is very high obtained the results of ( 83-86 % ), a student knowing and perceiving a model that dumpster in the islamic university campus menunujuk very high percentage of poor showing the perception is very high obtained the results of ( 83-85 % ), the awareness of the students faculty mipa against participation menunujuk very high percentage of these things that indicated the result of ( 80-89 % )
Uji Bakteri Total Coliform dan Escherichia coli Pada Sumber Mata Air Ubalan Desa Maguan Kecamatan Ngajum Kabupaten Malang
Authors: Aniansyah Octavia Shahilla , Syauqi Ahmad , Laili Saimul
Published: May 2023

Water is a very important human need and no life can exist without air. Human needs are generally obtained from various sources, both from groundwater, surface water and rainwater. Ubalan is a hamlet located in Ngajum District, Malang Regency. The location is under the foot of Mount Kawi - Malang which has a natural spring and is generally channeled by the surrounding community to fill artificial ponds and also used by the community to meet their daily needs. The use of spring sources is generally very diverse, including for drinking water, fisheries, conservation and as a tourist attraction. Water indicators such as total coliform bacteria and Escherichia coli. Regarding this statement, it is necessary to carry out a microbiological test to test for total coliform and Escherichia coli bacteria at the Ubalan spring, Maguan Village, Ngajum District, Malang Regency, which is a tourist attraction location that is never empty of visitors. The research method used is survey method and descriptive laboratory analysis. To take samples of air sources carried out randomly.

               The test results for Total Coliform and Escherichia coli bacteria in West Sumatra Mata Air Ubalan, Maguan Village, Ngajum District, Malang Regency, showed that the MPN results index was at station 3 (0.273) station 2 (0.188) and the lowest was at station 1 (0.138). The analysis is related to the level of the presence of total coliform and E. coli bacteria with pollutant source factors that are thought to come from human activities around the source, community behavior and the distance factor between air sources and exhaust locations. Correlation of research results obtained by the presence of total coliform bacteria and Escherichia coli in the air source with the relationship of factors between the supporting bacteria showed (p value = 0.188) which means it did not have a significant effect.
Skrining Potensi Essential Oil Cananga odorata dalam Penghambatannya Terhadap ACE II dan TMPRSS2 sebagai Anti Covid-19: Pendekatan In Silico
Authors: Bintari Yoni Rina , Wulandari Dian Novita
Published: May 2023

COVID-19 is a disease caused by viruses of the coronavirus class that are known to enter humans through the Angiotensin Coverting Enzyme (ACE II) receptor protein and transmembrane serine protease (TMPRSS 2). COVID-19 has become a pandemic, so it requires an agent that acts as an anti-Covid-19. Cananga odora is an herb that contains EO (Essential Oils) and is widely grown in Indonesia. EO are known to have antiviral potential.This study aims to explore the potential of EO from C.odora using a molecular docking approach by measuring its inhibition of ACE II (Q9BYF1) and TMPRSS2 (7MEQ). The inhibitory potential was calculated from the binding affinity using Pyrex Autodock Vina software. The docking results are then visualized using Biovia Discovery Studio and PyMOL. Prediction of physicochemical and pharmacokinetic profiles through pKCsm web. The docking results showed that geranyl acetate inhibited ACE II at Lys 562 with a gibs energy of -7.5 kcal. Thebest inhibition of TMPRSS2 by cedrole with energy gibs -6.2 kcal/mol via Pro 375. The active compound C. odorata has a different inhibitory mechanism from the control (chloroquine). The results of the in silico test predict the pharmacokinetic profile of EO from C.odora geranil asetat which has good absorption, distribution, metabolism and excretion values and is non-toxic, and cedrole can cross the blood brain barier.
Unveiling the Unseen: Exploring the Hidden Struggles Faced by College Students
Authors: Jasubhai Shilpa
Published: May 2023

Mental health is a critical concern that affects numerous individuals globally. In the case of students in India, mental health issues are especially pervasive. The pressure to excel academically and conform to societal norms often leads to feelings of stress, anxiety, and depression. In this article, we will explore the mental health challenges encountered by Indian students and provide some self-help suggestions.
EXTERNAL LOBBYING FOR GLOBAL FINANCIAL MARKET STANDARDS AND LEGAL PROTECTION OF RUSSIAN MONETARY AND FINANCIAL SOVEREIGNTY
Authors:   Moscow State Institute of International Relations of the Ministry of Foreign Affairs of Russia, Moscow, Russian Federation, PETROVA GALINA ,   Moscow University named after A.S. Griboedov (IMPE named after A.S. Griboedov)
Published: May 2023

Introduction. The article is connected with the importance of financial and legal analysis of the level of expediency and effectiveness of the use of external regulatory standards in the financial legislation of Russia as “global initiatives” in order to achieve standardization of monetary and financial regulation. It is noted that the process of introducing legislative initiatives into the financial law of the Russian Federation is subject to external influence through lobbying by self-regulatory and international financial organizations of global financial market standards. It is shown that external lobbying has not only positive, but also negative aspects that threaten the monetary and financial sovereignty of the state. Materials and methods. The most significant global codes of norms and principles of international financial organizations, the provisions of which are lobbied at the level of legislative initiative, are analyzed. Regulatory and analytical materials were used to assess the need for external influence of global financial standards on the legal norms of the Russian Federation in the field of monetary and financial regulation. The synergetic method in law, used by international organizations for the legal regulation of financial markets, is critically evaluated. Results. The lack of clear criteria for the responsible behavior of systemically important and other participants in financial markets in global standards was noted. There is abstract content of legally significant concepts of obligations and responsibilities in the global codes of the IMF, the Bank for International Settlements, the Council for Financial Stability on the principles of transparency of financial markets, on the set of principles of good faith behavior of participants in foreign exchange transactions, on the transparency of balances of payments, etc. Discussion and conclusions. The danger of external lobbying for “soft law” of financial markets lies in the fact that these norms are adopted without discussion at the UN level and without taking into account the interests of UN member states. Global financial standards threaten the monetary and financial sovereignty of states, creating a supranational monetary and financial structure of global regulation, bypassing the applicable law of national states. Not all global financial standards contribute to the development of the Russian financial sector in the context of a national economic growth strategy.
OPPORTUNITIES FOR MUTUAL ASSIMILATION OF LABOR LAW REGULATIONS OF THE RUSSIAN FEDERATION AND THE UAE IN CONDITIONS OF ACTIVATION OF MIGRATION FLOWS
Authors: ABDULLAEV ELSHAN
Published: May 2023

The article deals with the problem associated with the development of bilateral relations between countries on the issues of ensuring the rights of labor migrants, analyzes the possibilities of mutual assimilation of labor law norms of the Russian Federation and the UAE in the context of increased migration flows. This topic is relevant in the light of the fact that the existing conventional mechanism of labor law is not able to provide the principle of universality in the regulation of labor relations, and therefore other approaches are needed to solve the problems of international labor law, which is especially important in the context of expanding migration flows. The problem that has arisen is due to the fact that modern international law is based on a system of international conventions, which demonstrates its inability to create universal legal norms suitable for effective interaction between countries in the field of labor migration. The lack of universality forces countries to look for other mechanisms of legal interaction in the field of labor relations, using, in particular, the possibilities of bilateral legal cooperation, one of which is the mutual assimilation of labor law norms. The article determines that the modern civilizational situation leads to the collapse of the system of international law, to an understanding of the need to form legal systems that meet the needs of each individual state. On these grounds, conditions arise for the development of two polar legal paradigms, where one of the lines of the “split” is the labor law issue, which becomes one of the elements in creating a political consensus between Russia and the UAE. The article shows the unity of the positions of Russia and the UAE on this issue, points out the need to assimilate the labor law norms of the Russian Federation and the UAE, considering the increase in the flow of labor migrants.
DIGITALIZATION AND DEVELOPMENT OF CRIMINAL LEGISLATION
Authors:   The All-Russian State University of Justice (RLA of the Ministry of Justice of Russia), Moscow, Russian Federation, KORABELNIKOV SERGEJ
Published: May 2023

The article considers digitalization as a special social phenomenon. The relevance of the work lies in the fact that in recent years the importance of information exchange in society has been increasing. The subject of the research is public relations in the field of production, receipt, use and dissemination of information, information technology and artificial intelligence. The development of information technologies, the importance of artificial intelligence as a risk factor and as a means of countering the commission of crimes using artificial intelligence are shown. The prospects for the development of legislation, including criminal legislation in the field of the use of modern information technologies and artificial intelligence are considered.
SOSIALISASI PEMANFAATAN MEDIA SOSIAL UNTUK KEMANDIRIAN EKONOMI PEMUDA DI KENDARI
Authors: Wanti Irma , Ricky Ramadhan Moch , Taya La , Tarifu La , Amin Hasriani , Iba La , Joko Joko , Nila Farlin Wa Ode , Adji Pratama Rekha
Published: May 2023

The world is no longer round, but has become flat with the arrival of the internet. The increasing number of internet users after the pandemic has contributed to making the world flatter. The development of surveillance technology facilitates the transfer of information in real time from a remote corner of Indonesia to America, which can also be accessed instantly by the wider community, if the information is conveyed via television or website on the internet network. This encourages the creation of new professions such as content creators who utilize various social media platforms to support economic independence, especially for youth through social media. Internet users in regions, such as Kendari, Southeast Sulawesi, have also increased since 2020. However, until now, in general, the livelihoods of the people of Kendari city are still in the agriculture, plantation, livestock, fisheries and industrial sectors. Thus, this activity aims to build a new paradigm from the youth in Kendari city towards new livelihood variants by utilizing social media. The results of the socialization activities carried out, firstly, awakened awareness for the youth of Kendari city about the use of social media that can support economic independence. Second, the content creator profession is developing in Kendari city
Evaluating the Effect of Jointly Administering Synthetic Graft and Ankaferd Blood Stopper for Bone Recovery in Created Bone Deformities in Diabetic Rats
Authors: TANIK Abdulsamet , DOGRU Arzum Güler , GÜL Mehmet
Published: May 2023

Objective: In the present paper, it was purposed to examine the late impacts of bone tissue recoveries in combination with synthetic grafts and Ankaferd Blood Stopper (ABS), which are effective in bone wound healing in diabetic rats.

Methods: A total of 64 Wistar albino male rats with diabetes were studied. A bone deformity was generated in the calvarium of diabetic rats. These diabetic rats are divided into 4 different groups. Only saline was applied to the bone defect in group 1, Beta-tricalcium phosphate (β-TCP) graft was administered to Group 2, ABS solution to Group 3, (β-TCP+ABS) were administered to group 4. Eight rats from each group were sacrificed on the 28th day and another 8 rats on the 56th day. Immunohistochemical, histopathological, and Dual Energy X-ray Absorptiometry (DEXA) analyzes of the obtained samples were made.

Results: In histopathological measurements, osteoblastic activity and bone regeneration were considerably higher in the group treated with group 2 and group 4 when compared to the control group on the 28th and 56th day (p˂ .05). Western blotting findings showed that the osteopontin (OP) and osteonectin (ON) expression at 28th day increased dramatically in the treated with group 4. DEXA analyzes revealed that BMC values in groups treated with group 2, group 3 and group 4 on 28th day were considerably higher than the control group (p˂ .05).

Conclusion: We can believe and conclude that ABS in combination with a β-TCP bone graft will produce more successful outcomes on wound

healing and formation of new bone in diabetic rats.
Relationship Between Staging and Grading of Periodontitis and Periimplantitis: A Retrospective Study
Authors: ÖZTÜRK ÖZENER Hafize
Published: May 2023

Objective: The purpose of this retrospective study was to determine the relationship between peri-implantitis and stage/grade of periodontitis.

Methods: Records of 171 periodontitis patients with 318 dental implants were screened. Classification of diagnosed patients with periodontitis were done by both stage (1, 2, 3 and 4) and grade (A, B and C). Peri-implant health status was evaluated as no peri-implantitis or with peri-implantitis. Marginal bone loss severity of implants diagnosed with peri-implantitis, prosthesis type (single, bridge), location of dental implants (maxilla, mandibula, anterior and posterior), smoking (yes/no) and diabetes history (yes/no) of the patients were also evaluated. Analysis was done at implant level.

Results: A total of 203 (63.8%) dental implants were diagnosed with peri-implantitis. There were statistical differences in the stage and grade of periodontitis between implants diagnosed with no peri-implantitis and peri-implantitis (p
The opinions of postgraduate nursing students about evidence-based practice: A qualitative study
Authors: YURT Seher , KOLAÇ Nurcan , ŞEN Esra
Published: May 2023

Objective: This study was conducted for the purpose of exploring the opinions and experiences of postgraduate nursing students regarding evidence-based practice and its use in the clinical setting in Turkey.

Methods: A qualitative study design was employed. Data in this research study were collected through Semi-structured questions were asked face-to-face in focus group discussions.

Results: The findings of the study set forth the individual and organizational barriers that faced postgraduate nursing students in their efforts

to implement evidence-based practices. The main themes of the study were highlighted as: perceptions regarding evidence-based practice, the impact on the group cared for, challenges faced in the implementation, institutional support in applying practices. Subthemes were data verification, useful and reliable application, difficulties in communicating with colleagues, traditional views, troubles with team collaboration, the indifference of young colleagues, insufficient resources, and the need for a mentor in the workplace.

Conclusion: The students in their undergraduate programs, and elective courses on EBP should be added to the curriculum. In order to eliminate organizational barriers, institutions should establish EBP committee and mentoring system.
An MVA-based vector expressing cell-free ISG15 increases IFN-I production and improves HIV-1-specific CD8 T cell immune responses
Authors: Falqui Michela , Perdiguero Beatriz , Coloma Rocio , Albert Manuel , Marcos-Villar Laura , McGrail Joseph Patrick , Sorzano Carlos Óscar S. , Esteban Mariano , Gómez Carmen Elena , Guerra Susana
Published: May 2023

The human immunodeficiency virus (HIV), responsible of the Acquired Immune Deficiency Syndrome (AIDS), continues to be a major global public health issue with any cure or vaccine available. The Interferon-stimulated gene 15 (ISG15) encodes a ubiquitin-like protein that is induced by interferons and plays a critical role in the immune response. ISG15 is a modifier protein that covalently binds to its targets via a reversible bond, a process known as ISGylation, which is the best-characterized activity of this protein to date. However, ISG15 can also interact with intracellular proteins via non-covalent binding or act as a cytokine in the extracellular space after secretion. In previous studies we proved the adjuvant effect of ISG15 when delivered by a DNA-vector in heterologous prime-boost combination with a Modified Vaccinia virus Ankara (MVA)-based recombinant virus expressing HIV-1 antigens Env/Gag-Pol-Nef (MVA-B). Here we extended these results evaluating the adjuvant effect of ISG15 when expressed by an MVA vector. For this, we generated and characterized two novel MVA recombinants expressing different forms of ISG15, the wild-type ISG15GG (able to perform ISGylation) or the mutated ISG15AA (unable to perform ISGylation). In mice immunized with the heterologous DNA prime/MVA boost regimen, the expression of the mutant ISG15AA from MVA-Δ3-ISG15AA vector in combination with MVA-B induced an increase in the magnitude and quality of HIV-1-specific CD8 T cells as well as in the levels of IFN-I released, providing a better immunostimulatory activity than the wild-type ISG15GG. Our results confirm the importance of ISG15 as an immune adjuvant in the vaccine field and highlights its role as a potential relevant component in HIV-1 immunization protocols.
Combined immunodeficiency caused by pathogenic variants in the ZAP70 C-terminal SH2 domain
Authors: Mongellaz Cédric , Vicente Rita , Noroski Lenora M. , Noraz Nelly , Courgnaud Valérie , Chinen Javier , Faria Emilia , Zimmermann Valérie S. , Taylor Naomi
Published: May 2023

Introduction

ZAP-70, a protein tyrosine kinase recruited to the T cell receptor (TCR), initiates a TCR signaling cascade upon antigen stimulation. Mutations in the ZAP70 gene cause a combined immunodeficiency characterized by low or absent CD8+ T cells and nonfunctional CD4+ T cells. Most deleterious missense ZAP70 mutations in patients are located in the kinase domain but the impact of mutations in the SH2 domains, regulating ZAP-70 recruitment to the TCR, are not well understood.

Methods

Genetic analyses were performed on four patients with CD8 lymphopenia and a high resolution melting screening for ZAP70 mutations was developed. The impact of SH2 domain mutations was evaluated by biochemical and functional analyses as well as by protein modeling.

Results and discussion

Genetic characterization of an infant who presented with pneumocystis pneumonia, mycobacterial infection, and an absence of CD8 T cells revealed a novel homozygous mutation in the C-terminal SH2 domain (SH2-C) of the ZAP70 gene (c.C343T, p.R170C). A distantly related second patient was found to be compound heterozygous for the R170C variant and a 13bp deletion in the ZAP70 kinase domain. While the R170C mutant was highly expressed, there was an absence of TCR-induced proliferation, associated with significantly attenuated TCR-induced ZAP-70 phosphorylation and a lack of binding of ZAP-70 to TCR-ζ. Moreover, a homozygous ZAP-70 R192W variant was identified in 2 siblings with combined immunodeficiency and CD8 lymphopenia, confirming the pathogenicity of this mutation. Structural modeling of this region revealed the critical nature of the arginines at positions 170 and 192, in concert with R190, forming a binding pocket for the phosphorylated TCR-ζ chain. Deleterious mutations in the SH2-C domain result in attenuated ZAP-70 function and clinical manifestations of immunodeficiency.