bluuebunny/crossref_metadata_2025 huggingface dataset:
Family factors and health‐related quality of life within 6 months of completion of childhood cancer treatment
Authors: al Ghriwati Nour , Stevens Evelyn , Velázquez‐Martin Bianca , Hocking Matthew C. , Schwartz Lisa A. , Barakat Lamia P.
Published: November 2020

Objective

The transition from active cancer treatment to survivorship represents a period of uncertainty for youth and their families, but factors associated with adaptation during this period are understudied. We evaluated associations among cancer and treatment‐related variables, family factors (family functioning, caregiver health‐related quality of life [HRQL], and caregiver distress), and patient HRQL after treatment completion. We assessed the indirect effects of neurocognitive difficulties on youth HRQL through family factors.

Methods

One hundred fifty‐four caregivers (of patients’ ages 0–18 years) and 52 youth (ages 7–18 years) completed questionnaires assessing family factors, neurocognitive difficulties, and HRQL for patients within 6 months following treatment completion. Electronic health records were reviewed for cancer and treatment‐related information. Bootstrapping analyses assessed whether neurocognitive function had indirect effects on HRQL through family factors.

Results

Family factors were associated with self‐ and caregiver reports of children's HRQL. Controlling for demographic, cancer, and treatment covariates, caregiver reports of their child's neurocognitive difficulties had an indirect effect on their reports of child physical HRQL through family functioning. Caregiver reports of their child's neurocognitive difficulties indirectly related to caregiver reports of child psychosocial HRQL through family functioning and caregiver HRQL. Indirect effects for self‐reported neurocognitive difficulties and HRQL were not supported.

Conclusions

Findings highlight the need for routine psychosocial screening for youth and caregiver reports of family adjustment and HRQL during the transition off treatment. Providers are encouraged to offer interventions matched to specific needs for families at risk for poor family functioning to improve patient outcomes as they transition off treatment.
Quantifying improvements in water‐stable aggregation caused by corn stover retention
Authors: Ojekanmi Abimbola , Johnson Jane M. F.
Published: November 2020

Corn (Zea mays L.) stover harvest must be balanced against protecting soil properties, including water‐stable aggregates (WSA). The formation and maintenance of WSA functions of multiple factors including management. Harvesting stover alters the mass of the residue retained, which might alter a soil's ability to form and maintain WSA. A study was conducted on two independently replicated fields under chisel plow (CP) and no‐till (NT) management, both in a corn–soybean [Glycine max. (L.) Merr.] rotation with four corn residue retention treatments (RRT): [harvesting only grain, grain plus cobs, grain plus about half the stover, and grain plus as much stover as possible (Grain + Aggressive)], returning about 8, 5, 4 and 2 Mg ha−1 yr−1 dry stover, respectively. Water‐stable aggregates, their distribution, and mean weight diameter (MWD) were determined on a clay loam or loam Mollisol collected at 0 to 5 and 5 to 10 cm. Treatments, crop phase, soil depth, and their interactions were analyzed via a mixed linear model. Linear regression was used to assay the relationships between WSA and the average mass of residue returned. In both fields, Grain + Aggressive had the lowest WSA and MWD, and fewer ≥2‐mm aggregates than other RRTs and, in the NT field, fewer in the 1‐ to 2‐mm class size as well. Overall, WSA increased by 0.85 and 2.25% per Mg stover returned under CP and NT, respectively. Harvesting stover reduced the formation and/or the maintenance of WSA, thereby reducing their ability to resist the erosive force of water.
Functional principal component analysis for longitudinal data with informative dropout
Authors: Shi Haolun , Dong Jianghu , Wang Liangliang , Cao Jiguo
Published: November 2020

In longitudinal studies, the values of biomarkers are often informatively missing due to dropout. The conventional functional principal component analysis typically disregards the missing information and simply treats the unobserved data points as missing completely at random. As a result, the estimation of the mean function and the covariance surface might be biased, resulting in a biased estimation of the functional principal components. We propose the informatively missing functional principal component analysis (imFunPCA), which is well suited for cases where the longitudinal trajectories are subject to informative missingness. Computation of the functional principal components in our approach is based on the likelihood of the data, where information of both the observed and missing data points are incorporated. We adopt a regression‐based orthogonal approximation method to decompose the latent stochastic process based on a set of orthonormal empirical basis functions. Under the case of informative missingness, we show via simulation studies that the performance of our approach is superior to that of the conventional ones. We apply our method on a longitudinal dataset of kidney glomerular filtration rates for patients post renal transplantation.
Engineering Surface N‐Vacancy Defects of Ultrathin Mesoporous Carbon Nitride Nanosheets as Efficient Visible‐Light‐Driven Photocatalysts
Authors: Yang Fan , Li Haoze , Pan Kai , Wang Shijie , Sun Huapeng , Xie Ying , Xu Yachao , Wu Jiaxing , Zhou Wei
Published: November 2020

Graphitic carbon nitride (GCN) has become an attractive photocatalyst for solar energy conversion, but the photocatalytic activity of GCN is still limited by the extremely fast electron–hole recombination. Herein, a defective ultrathin mesoporous graphitic carbon nitride (DUMCN) photocatalyst with high specific surface area and mesoporous structure is fabricated through a facile three‐step heat‐treatment strategy, which reduces the distance of bulk photogenerated carriers to the surface, resulting in efficient adsorption and diffusion of reactants and products, and exposing adequate surface active sites. Moreover, suitable N‐vacancy defects are formed via high‐temperature surface hydrogenation, which can extend light absorption and produce ultra‐high intrinsic carrier mobility, and further increase the active sites. The photocatalytic hydrogen production rate is up to 13.63 mmol h−1 g−1 under visible light in the triethanolamine solution and 33.5 μmol h−1 g−1 for overall water splitting, which is much higher than that of bulk graphitic carbon nitride (BCN) structures. Density functional theory (DFT) calculations further reveal the effect of surface defects on the band structure for promoting the spatial charge separation. This facile strategy may offer new insights into designing other ultrathin mesoporous semiconductor photocatalysts with high performance.
Assembly of Fe(III)‐Grafted Metal–Organic Complexes as p‐Type Dopants for Efficient and Stable Perovskite Solar Cells
Authors: Zhou Xuesong , Hao Sue , Qiu Lele , Fan Ruiqing , Zhang Jian , Yang Yulin
Published: November 2020

Realizing the rapid/controllable oxidation of 2,2′,7,7′‐tetrakis(N,N‐di‐p‐methoxyphenylamine)‐9,9′‐spirobifluorene (Spiro‐OMeTAD) under an inert atmosphere, reducing the J–V hysteresis and enhancing the air stability of devices is extremely significant to fabricate high‐performance perovskite solar cells (PSCs). Herein, the Fe(III) ion grafted metal–organic complexes (Fe(III) ⊂ MOCs) are assembled and used as the p‐type dopants of hole transport layers (HTLs) to prepare efficient and stable PSCs. Consequently, the optimal Fe(III) ⊂ In‐2‐bpydc‐doped device presents a significantly enhanced power conversion efficiency (PCE) of 20.46%, benefitting from the improved hole extraction and weakened carrier recombination at the interface between HTLs and perovskite films. More importantly, the modified device possesses a reduced J–V hysteresis index (HI) of 0.094, and can maintain nearly 90% of its initial PCE value after being exposed to the air at ≈25 °C and relative humidity (RH) of ≈35% for 4 weeks, which is attributed to the restrained detrimental penetration behavior by the MOC carrier part of dopants. This work is of important guiding significance for the application of MOC materials in photovoltaic fields.
Prediction model for recurrence of hepatocellular carcinoma after resection by using neighbor2vec based algorithms
Authors: Cao Yuankui , Fan Junqing , Cao Hong , Chen Yunliang , Li Jie , Li Jianxin , Zhang Simin
Published: November 2020

Liver cancer has become the third cause that leads to the cancer death. For hepatocellular carcinoma (HCC), as the highly malignant type of liver cancer, its recurrence rate after operation is still very high because there is no reliable clinical data to provide better advice for patients after operation. To solve the challenging issue, in this work, we design a novel prediction model for recurrence of HCC using neighbor2vec based algorithm. It consists of three stages: (a) In the preparation stage, the Pearson correlation coefficient was used to explore the independent predictors of HCC recurrence, (b) due to the low correlation between individual dimension and prediction target, K‐nearest neighbors (KNN) were found as a K‐vectors list for each patient (neighbor2vec), (c) all vectors lists were applied as the input of machine learning methods such as logistic regression, KNN, decision tree, naive Bayes (NB), and deep neural network to establish the neighbor2vec based prediction model. From the experimental results on the real data from Shandong Provincial Hospital in China, the proposed neighbor2vec based prediction model outperforms all the other models. Especially, the NB model with neighbor2vec achieves up to 83.02, 82.86, 77.6%, in terms of accuracy, recall rates, and precision.

This article is categorized under:

Technologies > Data Preprocessing

Technologies > Classification

Technologies > Machine Learning
Twisted string theory in anti-de Sitter space
Authors: Li Songyuan , Troost Jan
Published: November 2020

Abstract

We construct a string theory in three-dimensional anti-de Sitter space-time that is independent of the boundary metric. It is a topologically twisted theory of quantum gravity. We study string theories with an asymptotic N = 2 superconformal symmetry and demonstrate that, when the world sheet coupling to the space-time boundary metric undergoes a U(1) R-symmetry twist, the space-time boundary energy-momentum tensor becomes topological. As a by-product of our analysis, we obtain the world sheet vertex operator that codes the space-time energy-momentum for conformally flat boundary metrics.
Avoidance of high-risk linear structures by Skylarks in the early breeding season and implications for conservation management
Authors: Püttmanns Manuel , Balkenhol Niko , Filla Tim , Görlich Angela , Roeles Frank , Waltert Matthias , Gottschalk Eckhard
Published: November 2020

Linear structures in winter cereals like tramlines are frequently used but high-risk nesting sites for Eurasian Skylarks when crop vegetation becomes impenetrable during May. However, their influence on nest-site selection before vegetation greatly limits choice is less studied. Between 2017 and 2019, we located 32 nests in winter cereals during the early breeding season and show that Skylarks nested 2 m further away from linear structures than expected if nest location was random. We interpret this avoidance as anti-predation behavior and propose additional tramline fragments for conservation management. Moreover, we confirm earlier findings about a higher nest predation risk on linear structures and a shifting of nesting sites towards them in the later breeding season.
Admissible dissimilarity value (ADV) as a measure of subsampling reliability: case study North Sea cod (Gadus morhua)
Authors: Wischnewski Julia , Bernreuther Matthias , Kempf Alexander
Published: November 2020

The shape of the length frequency distribution (LFD) is an important input for stock assessments and one of the most important features in studies of fish population dynamics, providing estimates of growth parameters. In practice, oversampling may occur when sampling commercially important species. At times of more and more limited resources, the length sample size can be optimized at some stages of national or regional sampling programmes, without reducing the quality of stock assessments. The main objective of this study is to demonstrate a general distribution-free methodological approach for an optimization of sample size developed as an alternative to both analytical and bootstrap approaches. A novel framework to identify the reduced but still informative sample and to quantify the (dis) similarity between reduced and original samples is proposed. The identification procedure is based on the concept of reference subsample, which represents a theoretical minimal representative subsample that despite smaller sample size still preserves a reasonably precise LFD for certain species. The difference between the original sample and the reference subsample called admissible dissimilarity value (ADV) serves as the upper threshold and can be used to quantify the reliability of derived subsamples. Monte Carlo simulations were conducted to validate the approach under various LFD shapes. We illustrate in case studies how ADV can support to evaluate adequate sampling effort. The case studies focus on length samples from the German commercial vessels fishing for North Sea cod (Gadus morhua).
Foreign aid, oil revenues, and political accountability: Evidence from six experiments in Ghana and Uganda
Authors: de la Cuesta Brandon , Martin Lucy , Milner Helen V. , Nielson Daniel L.
Published: November 2020

Foreign aid may act much like oil money in reducing voters’ willingness to demand accountability from their government, enabling corruption, clientelism, and repression. This is an important causal mechanism connecting public budgets to quality of governance. Yet other scholarship counters that aid is more beneficial than oil, either indirectly because of donor oversight or directly because aid is more likely to produce citizen pressures on governments. Empirical work on the topic employs observational data at the national, macro level, and has left the question unresolved. At the micro level, in some countries citizens have experience with aid revenues and oil funds, thus possessing information about the political implications of these different revenue sources. This article provides the first experimental tests of the direct mechanism linking aid and oil revenues to demands from citizens for greater political accountability. We report the effects of randomly assigned treatments identifying aid funds compared to oil money on behavior of citizens in six survey and lab experiments in Ghana and Uganda. We find no differences in accountability pressures when subjects are randomly assigned to aid or oil conditions in any experiment, including a survey-based field experiment in Uganda that employed very strong information treatments on the extent of aid and oil funds. Though little evidence suggests that either windfall necessarily reduces accountability demands from baseline in a meaningful way, citizens’ actions for aid money were statistically indistinguishable from oil revenues across all experiments. Aid may well have governance effects through the indirect route of donor oversight, but the results presented here suggest no evidence that aid, compared to oil, directly induces greater accountability demands among citizens.
Diaphyseal femoral fracture due to severe vitamin D3 deficiency and low parathyroid hormone levels on long-term hemodialysis: a case report
Authors: Hatano Masaki , Kitajima Izuru , Isawa Kazuya , Hirota Yutaka , Suwabe Tatsuya , Hoshino Junichi , Sawa Naoki , Nakamura Masaki , Yamamoto Seizo , Ubara Yoshihumi
Published: November 2020

Introduction

Currently, there are no reports of diaphyseal femoral fracture equivalent to atypical femoral fractures (AFFs) in patients receiving long-term hemodialysis (HD).

Case report

A 56-year-old Japanese man receiving long-term HD for 34 years was admitted to our hospital due to a delay in postoperative healing. The patient began maintenance hemodialysis at 22 years of age. The patient then underwent surgical parathyroidectomy (PTX) for secondary hyperparathyroidism at 43 years of age, which resulted in decreased levels of parathyroid hormone (PTH). Thereafter, this patient’s serum 1,25(OH)2D3level was very low because active vitamin D3derivative was not administered. At 54 years of age, a transverse fracture of the femoral shaft equivalent to AFF occurred. Surgery with open reduction and internal fixation using intramedullary nailing was performed; however, the delay of postoperative healing continued for 16 months. A left iliac crest bone biopsy was performed and showed osteoid-like lesion and an increase of woven bone. The patient received active vitamin D3derivative and recombinant human PTH (1–34) derivative. Twenty-nine months after the first surgery, a reoperation was performed. Simultaneously, a right iliac crest bone biopsy was performed. Bone morphometrical improvement was confirmed. Six months after resurgery, the bone union was achieved.

Severe vitamin D3deficiency and decreased levels of PTH may induce a higher osteoid state and an increase of woven bone, which may then attribute to the development of diaphyseal femoral fracture and impairment of postoperative bone healing. It is hypothesized that treatment with active vitamin D3and teriparatide acetate may be a therapeutic option via the accelerated formation of lamellar bone for refractory diaphyseal femoral fracture of long-term dialysis.
Softening Behavior of Cold-Sprayed Aluminum-Based Coatings AA1200 and AA7075 During Annealing
Authors: Bobzin K. , Wietheger W. , Hebing J. , Gerdt L.
Published: November 2020

For lightweight constructions, joining dissimilar metals is often indispensable to achieve exceptional properties. A common challenge is the bonding of steel and aluminum parts. The use of cold-sprayed coatings as a bonding agent is an innovative approach for high pressure die casting (HPDC) aluminum-steel hybrid components in order to achieve a metallurgical bonding, although it comes with high requirements in terms of coating adhesive and cohesive strength. Therefore, the main aim of this study is the optimization of a post-processing treatment of cold-sprayed coatings in order to improve the cohesive strength to help the introduced coatings withstand the mechanical and thermal stresses during HPDC. The effect of the heat treatment on the mechanical properties of the cold-sprayed Al99.0 and AA7075 coatings was investigated. Freestanding coatings were heat-treated at a temperature of T = 400 °C for different dwell times in order to analyze the recrystallization kinetics through hardness measurements. Two different heat treatment states along with an as-sprayed condition were chosen to investigate the evolution of the mechanical properties of the coatings by means of 3-point bending tests. Besides the softening of the coatings during the heat treatment, sintering effects at splat boundaries and their impact on fracture mechanisms were investigated using electron microscopy.
Characterization and oil recovery enhancement by a polymeric nanogel combined with surfactant for sandstone reservoirs
Authors: Almahfood Mustafa , Bai Baojun
Published: November 2020

The characterization and enhanced oil recovery mechanisms of a nanosized polymeric cross-linked gel are presented herein. A negatively charged nanogel was synthesized using a typical free radical suspension polymerization process by employing 2-acrylamido 2-methyl propane sulfonic acid monomer. The synthesized nanogel showed a narrow size distribution with one peak pointing to a predominant homogeneous droplet size. The charged nanogels were also able to adsorb at the oil–water interfaces to reduce interfacial tension and stabilize oil-in-water emulsions, which ultimately improved the recovered oil from hydrocarbon reservoirs. In addition, a fixed concentration of negatively charged surfactant (sodium dodecyl sulfate or SDS) was combined with different concentrations of the nanogel. The effect of the nanogels combined with surfactant on sandstone core plugs was examined by running a series of core flooding experiments using multiple flow patterns. The results show that combining nanogel and SDS was able to reduce the interfacial tension to a value of 6 Nm/m. The core flooding experiments suggest the ability of the nanogel, both alone and combined with SDS, to improve the oil recovery by a factor of 15% after initial seawater flooding.
On kernels of Toeplitz operators
Authors: Nowak M. T. , Sobolewski P. , Sołtysiak A. , Wołoszkiewicz-Cyll M.
Published: November 2020

We apply the theory of de Branges–Rovnyak spaces to describe kernels of some Toeplitz operators on the classical Hardy space $$H^2$$

H
2

. In particular, we discuss the kernels of the operators $$T_{{\bar{f}}/ f}$$

T

f

¯

/
f

and $$T_{{\bar{I}}{\bar{f}}/ f}$$

T

I

¯

f

¯

/
f

, where f is an outer function in $$H^2$$

H
2

and I is inner such that $$I(0)=0$$

I
(
0
)
=
0

. We also obtain a result on the structure of de Branges–Rovnyak spaces generated by nonextreme functions.
Taste receptor polymorphisms and longevity: a systematic review and meta-analysis
Authors: Di Bona Danilo , Malovini Alberto , Accardi Giulia , Aiello Anna , Candore Giuseppina , Ferrario Anna , Ligotti Mattia E. , Maciag Anna , Puca Annibale A. , Caruso Calogero
Published: November 2020

Bitter taste receptors (TAS2R) are involved in a variety of non-tasting physiological processes, including immune-inflammatory ones. Therefore, their genetic variations might influence various traits. In particular, in different populations of South Italy (Calabria, Cilento, and Sardinia), polymorphisms of TAS2R16 and TAS238 have been analysed in association with longevity with inconsistent results. A meta-analytic approach to quantitatively synthesize the possible effect of the previous variants and, possibly, to reconcile the inconsistencies has been used in the present paper. TAS2R38 variants in the Cilento population were also analysed for their possible association with longevity and the obtained data have been included in the relative meta-analysis. In population from Cilento no association was found between TAS2R38 and longevity, and no association was observed as well, performing the meta-analysis with data of the other studies. Concerning TAS2R16 gene, instead, the genotype associated with longevity in the Calabria population maintained its significance in the meta-analysis with data from Cilento population, that, alone, were not significant in the previously published study. In conclusion, our results suggest that TAS2R16 genotype variant is associated with longevity in South Italy.
Experimental and numerical study on fretting wear and fatigue of full-scale railway axles
Authors: Zou Lang , Zeng Dongfang , Li Yabo , Yang Kai , Lu Liantao , Yuan Caiqin
Published: November 2020

This study investigated the fretting wear and fatigue of full-scale railway axles. Fatigue tests were conducted on full-scale railway axles, and the fretting wear and fretting fatigue in the fretted zone of the railway axles were analysed. Three-dimensional finite element models were established based on the experimental results. Then, multi-axial fatigue parameters and a linear elastic fracture mechanics-based approach were used to investigate the fretting fatigue crack initiation and propagation, respectively, in which the role of the fretting wear was taken into account. The experimental and simulated results showed that the fretted zone could be divided into zones I–III according to the surface damage morphologies. Fretting wear alleviated the stress concentration near the wheel seat edge and resulted in a new stress concentration near the worn/unworn boundary in zone II, which greatly promoted the fretting crack initiation at the inner side of the fretted zone. Meanwhile, the stress concentration also increased the equivalent stress intensity factor range ΔKeq below the mating surface, and thus promoted the propagation of fretting fatigue crack. Based on these findings, the effect of the stress redistribution resulting from fretting wear is suggested to be taken into account when evaluating the fretting fatigue in railway axles.
Recovery of vanadium and tungsten from waste selective catalytic reduction catalysts by K2CO3 roasting and water leaching followed by CaCl2 precipitation
Authors: Liu Xianghui , Yang Qiaowen
Published: November 2020

Waste selective catalytic reduction (SCR) catalysts are potential environmental hazards. In this study, the recovery of vanadium and tungsten from waste SCR catalysts by K2CO3 roasting and water leaching was investigated. The roasting and leaching conditions were optimized: the leaching efficiencies of vanadium and tungsten were 91.19% and 85.36%, respectively, when 18 equivalents of K2CO3 were added to perform the roasting at 900 °C for 2 h, followed by leaching at 90 °C for 1 h. Notably, in the described conditions, the leaching rate of silicon was only 28.55%. Titanates, including K2Ti6O13 and KTi8O17, were also produced. Si removal was achieved in 85% efficiency adjusting the pH to 9.5, and the Si impurity thus isolated was composed of amorphous Si. Tungsten and vanadium were precipitated using CaCl2. At pH 10 and following the addition of 0.10 mol of H2O2 and 16 equivalents of CaCl2, the precipitating efficiencies of tungsten and vanadium were 96.89% and 99.65%, respectively. The overall yield of tungsten and vanadium was 82.71% and 90.87%, respectively.

Graphic abstract
Leaf age is important for assessment of resistance in chrysanthemum against Frankliniella occidentalis
Authors: Rogge Sina Alexandra , Meyhöfer Rainer
Published: November 2020

Feeding behaviour of pest insects on host plants depends on the plant morphology and chemical composition. So far, leaf position was demonstrated important for estimation of thrips resistance in Capsicum, where resistant associations showed a higher resistance in the youngest leaves compared to old leaves. In the current study, the feeding behaviour of female Frankliniella occidentalis, a major pest of chrysanthemum, and the egg-laying activity was assessed in a non-choice experiment in the climate chamber. We hypothesize that the physiological status, i.e. the age of chrysanthemum leaves, is an important resistance factor influencing thrips silver damage and the number of offspring. In general, the results show significantly higher feeding damage on old (basal) leaves of susceptible cultivars compared to resistant cultivars on the abaxial side of the leaf. In contrast, we detected no significant differences on the adaxial side of the leaves neither for old nor for young leaves. However, feeding damage on different leaf positions is an important factor for resistance level determination. Additionally, we detected significant differences in reproductive activity, i.e. number of hatched larvae on old leaves compared to young leaves for all cultivars. Overall, on old leaves we detected more larvae. The comparison between the old leaves of all cultivars exhibited a significant difference between one resistant and one susceptible cultivar. Contrary to that, the comparison between the young leaves of all cultivars exhibited no significant differences. All findings are important for advancing future resistance screenings in chrysanthemum.
How Local Governments Govern Culture War Conflicts
Authors: Chou Mark , Busbridge Rachel
Published: November 2020

While local governments have traditionally been thought relatively powerless and unpolitical, this has been rapidly changing. Recent years have seen local governments jump headfirst into a range of so-called culture war conflicts like those concerning LGBTI rights, refugee protection, and climate change. Using the Australia Day and Columbus Day controversies as case studies, this Element rejuvenates research on how local governments respond to culture war conflicts, documenting new fronts in the culture wars as well as the changing face of local government. In doing this, this Element extends foundational research by advancing four new categories of responsiveness that scholars and practitioners can employ to better understand the varied roles local governments play in contentious culture war conflicts.
Measuring the strength of threats, rewards, and appeals in persuasive negotiation dialogues
Authors: Morveli-Espinoza Mariela , Nieves Juan Carlos , Tacla Cesar Augusto
Published: November 2020

The aim of this article is to propose a model for the measurement of the strength of rhetorical arguments (i.e., threats, rewards, and appeals), which are used in persuasive negotiation dialogues when a proponent agent tries to convince his opponent to accept a proposal. Related articles propose a calculation based on the components of the rhetorical arguments, that is, the importance of the goal of the opponent and the certainty level of the beliefs that make up the argument. Our proposed model is based on the pre-conditions of credibility and preferability stated by Guerini and Castelfranchi. Thus, we suggest the use of two new criteria for the strength calculation: the credibility of the proponent and the status of the goal of the opponent in the goal processing cycle. We use three scenarios in order to illustrate our proposal. Besides, the model is empirically evaluated and the results demonstrate that the proposed model is more efficient than previous works of the state of the art in terms of numbers of negotiation cycles, number of exchanged arguments, and number of reached agreements.
Autonomous Sensory Meridian Response
Authors: Roberts Natalie , Beath Alissa , Boag Simon
Published: November 2020

Abstract. Autonomous Sensory Meridian Response (ASMR) is a pleasurable, tingling sensation induced by exposure to specific, audio-visual triggers, producing feelings of relaxation and euphoria. This article examines the relationship between ASMR propensity using a recently developed self-report measure (ASMR-15), Big-Five personality factors, and sensory-processing sensitivity (SPS), in a general population. Thus far, the ASMR-15 has only been validated on self-selected ASMR-specific samples, and so it is yet to be determined whether the measure may be adapted to assess ASMR in a non-specialized sample. To address this, N = 187 undergraduate psychology students were recruited for a survey study. ASMR was related to greater Openness and SPS, and lower Conscientiousness. A confirmatory factor analysis was undertaken on the ASMR-15, largely replicating the factor structure previously demonstrated. As a result, the ASMR-15 may be useful for researchers interested in further exploring ASMR experiences in both specialized and non-specialized samples.
Characteristics of Electron Precipitation During 40 Energetic Electron Injections Inferred via Subionospheric VLF Signal Propagation
Authors: Ghaffari R. , Cully C. M. , Turner D. L. , Reeves G. D.
Published: November 2020

Energetic electron injection events are associated with energetic electron precipitation (EEP) through possible resonant wave‐particle interactions. Previous studies confirm the impacts of injection‐driven precipitation on observed amplitude/phase of subionospheric VLF (very low frequency) signals transmitted from distant artificial transmitters. Currently, there are substantial uncertainties on precipitation characteristics and flux during injection events. In this work we study 40 injection events selected by Van Allen Probes particle data to investigate the changes in amplitude and phase of VLF signals at ground receivers across Canada during particle injection events. We model the ionospheric effect of the EEP flux to find its impact on VLF propagation and characterize the injection events. Typically, we find a clear phase advance of ~40° in the received VLF signal at Fort Smith (Canada, L = 8) transmitted from U.S. Navy communication transmitter NAA at Maine (USA). Comparing to other VLF transmitter‐receiver paths in North America leads us to conclude that effects are only seen on paths with adequately large range ≫200 km) through L > 7. Modeling the VLF phase change indicates that in the majority of events (>90%), less than 10% of the strong scattering limit inferred from particle flux measurements at the Van Allen Probes is required to obtain the observed VLF phase signature. The median precipitating flux during energetic particle injections is less than 4 × 106 el/cm2 s sr (<10% of the strong scattering rate) for electrons above ~40 keV extracted from trapped particles energy spectrum. This implies that strong scattering is not typical for these 40 selected energetic electron injection events.
Hydrogen Isotope Composition of a Large Silicic Magma Reservoir Preserved in Quartz‐Hosted Glass Inclusions of the Bishop Tuff Plinian Eruption
Authors: Befus Kenneth S. , Walowski Kristina J. , Hervig Richard L. , Cullen Jeffrey T.
Published: November 2020

Water controls magmatic crystallization and drives volcanic eruptions, but little is known about its primary source in silicic systems. The hydrogen isotope composition of volcanic products provides a metric that can track and identify magmatic source, fractionation, or degassing processes. Despite such promise, hydrogen isotope measurements have never previously been acquired for undegassed silicic melt. To explore whether hydrogen isotopes can identify the source and modification of water in a silicic magma reservoir, we analyzed D/H ratios and dissolved H2O content of quartz‐hosted, rhyolitic glass inclusions from the early Bishop Tuff, a time‐honored testing ground for innovative petrologic studies. The rhyolitic inclusions indicate the early Bishop reservoir had δD values ranging from −40‰ to −60‰ (Vienna Standard Mean Ocean Water). The measured hydrogen isotope ratios do not follow systematic trends that would be predicted for open‐system degassing, rehydration, or diffusive loss. Observed isotopic variability in the microanalyses is instead attributed to analytical artifacts. The large silicic reservoir degassed as a closed system, resulting in limited fractionation obscured by the uncertainty of the measurements. Significant modification of melt D/H ratios by assimilation and fractional crystallization are unlikely, as their projected contributions are not observed. Dynamic geologic processes are thus not recorded by the hydrogen isotope composition of the inclusions. Instead, the rhyolitic melt represents a distinct, largely homogenous isotopic reservoir. When compared to the global record of basaltic glass inclusions, the rhyolitic inclusions preserve an isotopic signature that is most similar to subduction‐related mafic melts.
Identification and Classification of Archeological Materials From Bronze Age Gold Mining Site Ada Tepe (Bulgaria) Using Rock Magnetism
Authors: Jordanova Neli , Jordanova Diana , Tcherkezova Emilia , Popov Hristo , Mokreva Antonia , Georgiev Plamen , Stoychev Ruslan
Published: November 2020

Archeological materials from the most ancient open‐pit gold mine in Europe have been investigated using mineral magnetic methods as part of the multidisciplinary research of the site. The aim of the study was to employ rock‐magnetic characteristics (magnetic susceptibility, anhysteretic remanent magnetization, isothermal remanent magnetization and various magnetic grain‐size dependent ratios) for classification of a collection of 177 samples, taken from Late Bronze age waste heaps, pristine rocks, natural soils and soils from cultural layers. Factor analysis and k‐means cluster analysis revealed that four clusters explain the best mineral magnetic data. Results from the thermomagnetic analysis and thermal demagnetization of composite isothermal remanence proved that the main magnetic minerals in the collection are magnetite/maghemite, hematite, and goethite. Based on the magnetic properties, samples from clusters 1 and 3 were identified as influenced by fire—archeological structures and waste heaps with the use of fire setting, respectively. Samples belonging to cluster 2 were dominated by goethite and hematite, thus identified as rock residues. Materials grouped in cluster 4 showed magnetic characteristics typical of natural soils and were thus related to this class of materials. The obtained clustering of the samples agreed well with their archeological assignment. Spatial distribution of cluster members across the site provides valuable environmental information for the location of the mining activities, their lateral spread and the technology used. It was concluded that magnetic mineral analysis is a precise, sensitive, and a highly effective method for characterization and classification of materials from ancient mining.
Global Propagation of Magnetospheric Pc5 ULF Waves Driven by Foreshock Transients
Authors: Wang Boyi , Liu Terry , Nishimura Yukitoshi , Zhang Hui , Hartinger Michael , Shi Xueling , Ma Qianli , Angelopoulos Vassilis , Frey Harald U.
Published: November 2020

Pc5 (2–7 mHz) ultralow frequency (ULF) waves play a significant role in resonating with particles and transferring energy in the coupled magnetospheric and ionospheric system. Recent studies found that Pc5 ULF waves can be triggered by foreshock transients which can perturb the magnetopause through dynamic pressure variation. However, whether foreshock transient‐driven Pc5 ULF waves are geoeffective and can propagate globally is still poorly understood. In this study, we take advantage of the conjunction between in situ (by the THEMIS probes, Geotail satellite, GOES satellites, and Van Allen probes) and ground‐based (by the all‐sky imager at South Pole and ground‐based magnetometers) observations to simultaneously analyze the waves from the foreshock region to the dayside and nightside magnetosphere. Both of our two events show that the Pc5 ULF waves are generated by foreshock transients in the dayside magnetosphere. The in situ observations by THEMIS A and D and the 2‐D auroral signatures show that the compressional mode waves are likely broadband and coupled to the FLRs with different frequencies and different azimuthal phase speeds. This is the first report that foreshock transients can drive both low‐ and high‐m FLRs, with the azimuthal wave numbers varying from ~5 to ~23. Moreover, the Pc5 ULF waves propagated antisunward to midnight, this can potentially modulate magnetospheric and ionospheric dynamics globally.
Using Tracer Variance Decay to Quantify Variability of Salinity Mixing in the Hudson River Estuary
Authors: Warner John C. , Geyer W. Rockwell , Ralston David K. , Kalra Tarandeep
Published: November 2020

The salinity structure in an estuary is controlled by time‐dependent mixing processes. However, the locations and temporal variability of where significant mixing occurs is not well‐understood. Here we utilize a tracer variance approach to demonstrate the spatial and temporal structure of salinity mixing in the Hudson River Estuary. We run a 4‐month hydrodynamic simulation of the tides, currents, and salinity that captures the spring‐neap tidal variability as well as wind‐driven and freshwater flow events. On a spring‐neap time scale, salinity variance dissipation (mixing) occurs predominantly during the transition from neap to spring tides. On a tidal time scale, 60% of the salinity variance dissipation occurs during ebb tides and 40% during flood tides. Spatially, mixing during ebbs occurs primarily where lateral bottom salinity fronts intersect the bed at the transition from the main channel to adjacent shoals. During ebbs, these lateral fronts form seaward of constrictions located at multiple locations along the estuary. During floods, mixing is generated by a shear layer elevated in the water column at the top of the mixed bottom boundary layer, where variations in the along channel density gradients locally enhance the baroclinic pressure gradient leading to stronger vertical shear and more mixing. For both ebb and flood, the mixing occurs at the location of overlap of strong vertical stratification and eddy diffusivity, not at the maximum of either of those quantities. This understanding lends a new insight to the spatial and time dependence of the estuarine salinity structure.
Revisiting the Detection of Optical Lightning Superbolts
Authors: Peterson Michael , Kirkland Matt W.
Published: November 2020

This study uses Fast On‐Orbit Detection of Transient Events (FORTE) satellite observations to identify superbolt‐class optical lightning events and evaluate their origins. Superbolts have been defined by Turman (1977, https://doi.org/10.1029/JC082i018p02566) as lightning pulses whose peak optical power exceeds 1011 W. However, it has been unclear whether superbolts resulted from particular types of high‐energy lightning process or whether they were the result of measurement bias. In the latter case, any decently bright lightning process could be recorded as a superbolt if the sensor had a particularly clear sight line to the hot channel without thick clouds diluting the optical signals. Our 12‐year analysis of FORTE superbolt detections indicates that the lower optical superbolt energy range (~100 GW) is dominated by normal lightning, but brighter cases are predominantly strong +CG strokes that originate from specific types of storms. Oceanic storm systems, particularly during the winter, and especially those located around Japan are shown to produce these intense superbolts. We suggest that some optical superbolts result from favorable viewing conditions and would not be identified as such by another instrument located elsewhere and that others are associated with a unique set of physics that may merit the “superbolt” distinction.
Association between DNA methylation and ADHD symptoms from birth to school age: a prospective meta-analysis
Authors: Neumann Alexander , Walton Esther , Alemany Silvia , Cecil Charlotte , González Juan Ramon , Jima Dereje D. , Lahti Jari , Tuominen Samuli T. , Barker Edward D. , Binder Elisabeth , Caramaschi Doretta , Carracedo Ángel , Czamara Darina , Evandt Jorunn , Felix Janine F. , Fuemmeler Bernard F. , Gutzkow Kristine B. , Hoyo Cathrine , Julvez Jordi , Kajantie Eero , Laivuori Hannele , Maguire Rachel , Maitre Léa , Murphy Susan K. , Murcia Mario , Villa Pia M. , Sharp Gemma , Sunyer Jordi , Raikkönen Katri , Bakermans-Kranenburg Marian , IJzendoorn Marinus van , Guxens Mònica , Relton Caroline L. , Tiemeier Henning
Published: November 2020

Attention-deficit and hyperactivity disorder (ADHD) is a common childhood disorder with a substantial genetic component. However, the extent to which epigenetic mechanisms play a role in the etiology of the disorder is unknown. We performed epigenome-wide association studies (EWAS) within the Pregnancy And Childhood Epigenetics (PACE) Consortium to identify DNA methylation sites associated with ADHD symptoms at two methylation assessment periods: birth and school age. We examined associations of both DNA methylation in cord blood with repeatedly assessed ADHD symptoms (age 4–15 years) in 2477 children from 5 cohorts and of DNA methylation at school age with concurrent ADHD symptoms (age 7–11 years) in 2374 children from 9 cohorts, with 3 cohorts participating at both timepoints. CpGs identified with nominal significance (p < 0.05) in either of the EWAS were correlated between timepoints (ρ = 0.30), suggesting overlap in associations; however, top signals were very different. At birth, we identified nine CpGs that predicted later ADHD symptoms (p < 1 × 10–7), including ERC2 and CREB5. Peripheral blood DNA methylation at one of these CpGs (cg01271805 in the promoter region of ERC2, which regulates neurotransmitter release) was previously associated with brain methylation. Another (cg25520701) lies within the gene body of CREB5, which previously was associated with neurite outgrowth and an ADHD diagnosis. In contrast, at school age, no CpGs were associated with ADHD with p < 1 × 10−7. In conclusion, we found evidence in this study that DNA methylation at birth is associated with ADHD. Future studies are needed to confirm the utility of methylation variation as biomarker and its involvement in causal pathways.
Key role for lipids in cognitive symptoms of schizophrenia
Authors: Maas Dorien A. , Martens Marijn B. , Priovoulos Nikos , Zuure Wieteke A. , Homberg Judith R. , Nait-Oumesmar Brahim , Martens Gerard J. M.
Published: November 2020

Schizophrenia (SZ) is a psychiatric disorder with a convoluted etiology that includes cognitive symptoms, which arise from among others a dysfunctional dorsolateral prefrontal cortex (dlPFC). In our search for the molecular underpinnings of the cognitive deficits in SZ, we here performed RNA sequencing of gray matter from the dlPFC of SZ patients and controls. We found that the differentially expressed RNAs were enriched for mRNAs involved in the Liver X Receptor/Retinoid X Receptor (LXR/RXR) lipid metabolism pathway. Components of the LXR/RXR pathway were upregulated in gray matter but not in white matter of SZ dlPFC. Intriguingly, an analysis for shared genetic etiology, using two SZ genome-wide association studies (GWASs) and GWAS data for 514 metabolites, revealed genetic overlap between SZ and acylcarnitines, VLDL lipids, and fatty acid metabolites, which are all linked to the LXR/RXR signaling pathway. Furthermore, analysis of structural T1-weighted magnetic resonance imaging in combination with cognitive behavioral data showed that the lipid content of dlPFC gray matter is lower in SZ patients than in controls and correlates with a tendency towards reduced accuracy in the dlPFC-dependent task-switching test. We conclude that aberrations in LXR/RXR-regulated lipid metabolism lead to a decreased lipid content in SZ dlPFC that correlates with reduced cognitive performance.
Exosome-derived ENO1 regulates integrin α6β4 expression and promotes hepatocellular carcinoma growth and metastasis
Authors: Jiang Keqiu , Dong Chengyong , Yin Zeli , Li Rui , Mao Jiakai , Wang Chengye , Zhang Junlin , Gao Zhenming , Liang Rui , Wang Qi , Wang Liming
Published: November 2020

Alpha-enolase (ENO1) has been found to be dysregulated in several human malignancies, including hepatocellular carcinoma (HCC). Although the role of ENO1 as a glycolytic enzyme in HCC cells has been well characterized, little is known about the other roles of ENO1, especially exosome-derived ENO1, in regulating HCC progression. Here, we demonstrated that ENO1 is frequently upregulated in HCC cells or tissues, with even higher expression in highly metastatic HCC cells or metastatic tissues as well as in exosomes derived from highly metastatic sources. Moreover, ENO1 expression is associated with the tumor-node-metastasis (TNM) stage, differentiation grade and poor prognosis in HCC patients. Surprisingly, ENO1 can be transferred between HCC cells via exosome-mediated crosstalk, exhibiting an effect similar to that of ENO1 overexpression in HCC cells, which promoted the growth and metastasis of HCC cells with low ENO1 expression by upregulating integrin α6β4 expression and activating the FAK/Src-p38MAPK pathway. In summary, our data suggest that exosome-derived ENO1 is essential to promoting HCC growth, metastasis, and further patient deterioration. The findings from this study implicate a novel biomarker for the clinical evaluation of HCC progression, especially the prediction of HCC metastatic risk.