bluuebunny/crossref_metadata_2025 huggingface dataset:
ORGANIZATION OF WORK ON EDUCATION FORMS OF CHILDREN WITH HEARING IMPAIRMENTS
Authors: Məmmədova Lalə
Published: August 2024

Speech plays an important role in the implementation of correctional work for children with disabilities. Speech and its development are closely related to the development of thinking. Special attention is paid to the development of speech and hearing, and the formation of the pronunciation side of speech in the course of educational work in special preschool institutions for deaf and hard-of-hearing children. The most acceptable forms of integration for children with hearing impairment include: temporary, combined and full integration. Temporary integration is the organization of special classes for deaf children in public schools. Pupils of these classes can participate in the teaching of certain subjects with a low speech load, for example, fine arts, labor, physical education classes, and extracurricular activities of the school together with the hearing ones.
THE IMPLEMENTATION OF INCLUSIVE EDUCATION AND THEIR ROLES IN MODERN EDUCATION IN NORWAY AND SWEDEN
Authors: Həmidova Xalidə , Muradalı Səkinə ,   Xəzər Universiteti
Published: August 2024

This article presents viewpoints on inclusive education in 2 developed European nations, including Norway and Sweden. Inclusive education, which seeks to give equal opportunity to all students, including those with impairments or special needs, is gaining popularity throughout Europe. Each country tackles inclusive education differently, with unique legislation, practices, and obstacles. In Norway, inclusive education is defined as a commitment to integrating students with disabilities into regular schools whenever possible. Sweden has made a similar commitment to integrating kids with impairments into regular classrooms while providing appropriate support. While these countries are committed to inclusive education, the extent and execution differ depending on cultural, socioeconomic, and political variables. Understanding the various viewpoints on inclusive education across Europe is critical for guiding policy creation, exchanging best practices, and encouraging collaboration to guarantee equitable access to education for all children.
Mejora de la integridad de los sistemas de compras públicas a través del control y sistemas de gestión de la información. Perspectiva desde la gestión interna de un ciclo de compra
Authors: Ochsenius Robinson Iván
Published: August 2024

Aunque es sabido que la compra o contratación pública -con carácter general- ha ido avanzando en temas normativos y en un articulado complementario a la propia ley, no ha sido una tarea suficiente para mejorar los sistemas de adquisiciones tanto en su operatoria como en la disminución de malas prácticas o actos de corrupción. Los sistemas de control tradicionales no son suficientes, como tampoco la aplicación de las mismas dinámicas de trabajo y la gestión de la información que genera el proceso. Es aquí donde la integridad y un marco de actuación operativo al respecto podrían jugar un rol importante, sobre todo si se le desarrolla desde lo que tiene que decir el control, los sistemas de gestión de la información y una visión gerencial que englobe y dirija lo anterior. Para que la compra pública pueda jugar un papel estratégico y cumplir con criterios ambientales, sociales y de carácter innovativo tan demandados por estos tiempos y, sobre todo, brinde el beneficio de una adquisición oportuna, eficaz, eficiente y transparente, se hace imperativo: insertarla dentro de un marco de integridad que garantice el uso de recursos de forma transparente y por los cuales se rinda cuenta; un respeto a ley y a los marcos éticos; y una gestión interna óptima de todos los medios disponibles. Es entonces indispensable gestionar esta integridad desde una visión que englobe todo su ciclo de compra, donde el análisis y gestión permanente de sus etapas muestre no solo que se cumple la normativa y ética al respecto, sino que evidencie qué elementos no están agregando valor. El objetivo de este documento es señalar la relevancia que posee el control, los sistemas de gestión de la información y una visión gerencial y holística en un ciclo de compra pública, buscando destacar aspectos operativos en ellos que puedan mejorar y/o reforzar cada etapa de este proceso y sus resultados en lo referente al concepto de integridad. Asimismo, este trabajo desea complementar la visión mayormente legalista que se tiene de la operatoria de esta materia de abastecimiento, como expresa el Banco Mundial (2016b: 2) que “en síntesis, la contratación pública es un proceso de negocio dentro de un sistema público”.
Mayor competitividad en los procesos de reclutamiento y selección, ¿mejor satisfacción usuaria? Evidencia a partir de los servicios públicos del Estado chileno
Authors: Valdebenito Sebastián , Pliscoff Cristian
Published: August 2024

¿Tiene un efecto en la satisfacción usuaria la concursabilidad como medio de selección de funcionarios y funcionarias que ingresan a la administración pública? Este artículo busca desarrollar esta temática, en el marco de una discusión sobre el impacto del mérito en la gestión del Estado. Las administraciones públicas latinoamericanas están viviendo sucesos de cambio para instalar procesos en sus prácticas de gestión de personas. Al hacer esto, se busca dejar atrás prácticas clientelares o discrecionales e instalar mecanismos de selección que privilegien el mérito para ingresar a alguna repartición pública. Las cifras muestran avances en la materia, aunque aún con mucho espacio de mejora. Este trabajo maneja información de las reparticiones públicas chilenas respecto al uso de la concursabilidad, asociándola con la satisfacción usuaria, la cual está siendo medida en la administración pública de forma sistemática en los últimos años. Los resultados de este estudio confirman una relación positiva entre los niveles de concursabilidad y la satisfacción usuaria, sugiriendo que una selección más meritocrática en los concursos públicos de funcionarios supone una mejor gestión y desempeño en sus organizaciones. Finalmente, se presentan conclusiones referidas al caso chileno sobre la materia, que pueden ser de utilidad para otros sistemas administrativos públicos de América Latina.
Desenmascarando el tráfico ilegal de reptiles en redes sociales en México, 2024
Authors: Ramírez-Bravo Osvaldo Eric , Arreola-Martínez Angélica Guadalupe , Garabana-Quintana Bernardo
Published: August 2024

One of the most important threats to herpetofauna today is the illegal trafficking of species, which affects reptiles throughout the world. In Mexico, due to its great biodiversity, it is an important headquarters for the sale and purchase of natve and exotic species. To have concise data and know a new modus operandi on reptile trafficking in Mexico, we monitored several Facebook groups to identify the most common species and their origin.
IN THE LAND OF WARTIME RAPE: BOSNIA, CINEMA AND REPARATION
Authors: Simic Dr Olivera , Volcic Dr Zala
Published: August 2024

This paper focuses on one space of mass rape during the Bosnian war: The Vilina Vlas Hotel in Višegrad, Bosnia and Herzegovina. By analysing Jasmila Žbanić’s film, For Those Who Can Tell No Tales, the potential of cinema to address ethno-nationalistic tensions and contribute to the pursuit of justice is considered. In post-war BiH, dealing with past war crimes is a delicate and contentious process, and many scholars are critical of the International Criminal Tribunal’s approach to the challenges of rape as a war crime. This paper considers whether cinema contributes to the truth-seeking aspect of this process.  It is argued that Žbanić uses her film as a strategy for resistance, intervention, and justice, while promoting symbolic reparation.
BEYOND BURQAS, BOMBS, AND BOGEYMEN: AUSTRALIAN MUSLIMS AND THE MEDIA
Authors: Chopra Tasneem
Published: August 2024

This article draws upon the personal and broader experience of living as an Australian Muslim in a climate of Islamophobia perpetuated by media and politics. From the personal context to the sociological drivers of stereotypes, media trends and rhetoric from politicians, this article examines multiple angles from which anti-Muslim discourse has often become codified patriotism. The impact of Islamophobia in terms of violence exacted on Australian Muslims is examined as a consequence of this. This article concludes that State culpability needs to be recognised, in order for appropriate responsibility to be taken to remedy the consequences of demonisation. Further, journalists who fuel hate speech with irresponsible and biased reporting must be held accountable. A recommendation is made for Australian Muslims to be given a platform in mainstream media in order to regularly convey their experiences, expressing an authentic narrative to counter the manufactured one.
Gender, Culture, and the Legal Profession: A Traffic Jam at the Intersection
Authors: Nguyen Tuanh , Tang Reynah
Published: August 2024

The legal profession is an old and conservative one, which has had difficulty addressing diversity and inclusion, particularly in relation to gender. In this article, the issue of gender, culture, and the legal profession is tackled from two complementary perspectives: Tuanh Nguyen shares her journey as both an Asian Australian and a female in the law, while Reynah Tang reflects on the state of cultural diversity in the Australian legal profession and the reasons for the lack of such diversity. It is argued that the legal profession cannot wait for gender diversity to be solved, but rather that it is vital that cultural diversity be considered in parallel, and that concrete action be taken to address the barriers that exist. It should be acknowledged that this article examines cultural diversity from an Asian Australian perspective, but such issues are not restricted to people from Asian cultural backgrounds, as evidenced by the lack of diverse representation across racial/ethnic groups, and the formation of associations focused on promoting cultural diversity for Hellenic, Italian, Muslim, and French lawyers.
Scripting Raced and Gendered Myths of (Un)belonging
Authors: Kuo Rachel
Published: August 2024

Oppression shows up in ‘ambiguous and nebulous’ forms that are more difficult to pinpoint and acknowledge.[1] Derald Wing Sue defines racial microaggressions as ‘brief and commonplace daily verbal, behavioural, and environmental indignities, whether intentional or unintentional, that communicate hostile, derogatory, or negative racial slights and insults to the target person or group’.[2] These interactions take shape in everyday interactions concealed by benevolent intentions. Often also called “everyday racism” and “everyday sexism”, the prevalence of microaggressions extend and maintain ongoing social injustices as they are tied to larger systemic disparities and violations of human rights. In the United States, despite multicultural metaphors of melting pots and salad bowls, the culture of middle class whiteness still dominates what is perceived as “normal”. Such normalisation is quietly sustained through banal instantiations that police the boundaries of whiteness. These daily exclusions are part of our cultural narratives of gender and race. Below, I reflect on two commonly heard phrases from my own life, ‘Where are you really from?’ and ‘You’re so exotic’, and how they reinforce racial, gender, and cultural assumptions that are also linked to history and policy.[1] Derald Wing Sue et al, ‘Racial Microaggressions in Everyday Life: Implications for Clinical Practice’ (2007) 62(4) American Psychologist 271, 273.[2] Ibid.
Volume 5 Issue 2 Full Issue
Authors: Law & Human Dignity Griffith Journal of
Published: August 2024

Full Issue
#Rightsplaining: Political Spinertia or a Historic Future for Human Rights in Australia?
Authors: Coyne Benedict
Published: August 2024

These are dark times for human rights in Australia, and in the world with the un-righteous rise of right wing nationalists Trumpeting a new dawn of anti-rights and their leaders who are hostile to established International Human Rights Law institutions including the United Nations and its many various bodies and the International Criminal Court. The ascension of an Alt-Right who are not interested in truth, evidence or facts makes the job of a legal advocate increasingly challenging in a “post-truth”- “alternative fact”-dystopia. The silver lining of course is that the more extreme the rhetorical pendulum swings the more opportunities there are for all of us as advocates to stand up, speak out, and robustly reaffirm the value of basic human rights and fundamental freedoms as the building blocks of our “fair go”, lucky country, ANZAC-spirited way of life.
Foreigners Act and the Freedom of Movement of the Rohingyas in Bangladesh
Authors: Azad Ashraful
Published: August 2024

There are an estimated 200,000-500,000 Rohingya refugees in Bangladesh. Most of these refugees are living without any official recognition. Bangladesh has not signed the UN Refugee Convention neither has it any domestic refugee regime. The Rohingya people are usually considered ‘illegal foreigner’ under the Foreigners Act 1946. Consequently, they face various restrictions in Bangladesh. This article discusses the restriction on freedom of movement of the Rohingyas within the country and internationally. Based on the legal analysis and empirical findings, this article shows that the Rohingyas in Bangladesh live in fear of arrest and detention which deter their daily movement outside designated camps. However, despite obstacles, many Rohingyas manage to bypass the system using various informal and inconsistent ways.
A Reproductive Rights Framework Supporting Law Reform on Termination of Pregnancy in the Northern Territory of Australia
Authors: Belton Dr Suzanne , Gerry QC Felicity , Stulz Dr Virginia
Published: August 2024

This article describes the reproductive rights framework underpinning the campaign to reform the law on termination of pregnancy in the period 2013 to 2017 in the Northern Territory of Australia.  We begin by outlining the pre-reformed legislation governing abortion in the NT. We then evaluate the reformed 2017 law using the typology established by Cook and Ngwena,[1] namely: (1) whether the law provides evidence-based access to health care; (2) whether it provides transparent access to health care; and (3) whether it provides fair access to health care. We finish by remarking on the continuing problems with the legislation and conclude that only complete decriminalisation will fulfil Australia’s commitments under the Convention on the Elimination of All Forms of Discrimination Against Women (‘CEDAW’) and other human rights instruments.[1] Rebecca J Cook and Charles G Ngwena, 'Women's Access to Health Care: The Legal Framework' (2006) 94(3) International Journal of Gynecology & Obstetrics 216.
Why Dignity Is a Poor Reason to Legalise Assisted Suicide
Authors: Kurti Peter
Published: August 2024

A growing movement in support of assisted dying is bringing pressure to bear on Australian politicians to enact legislation making it legal for doctors to help people to die. Victoria has already legalised assisted suicide, and now the Western Australian parliament may introduce a similar law. Proponents of assisted suicide argue that the burden of great physical or mental suffering diminishes human dignity and that — in the name of compassion — people should be able to receive assistance to end their lives when they wish to do so.The word “dignity” is used in equivocal ways, however, and can refer both to an intrinsic dimension of human identity, and to an extrinsic, or social, dimension. Opponents of euthanasia and physician-assisted suicide tend to use dignity in its intrinsic sense whereas proponents use it in its extrinsic sense. There is, however, a response to those who argue that the demands of social dignity require the possibility for assisted suicide. This is the therapeutic option known as ‘dignity therapy’, increasingly used in palliative care to restore the social dignity of the terminally ill patient.In jurisdictions where assisted suicide is legal, the categories of those eligible for assistance in dying are already expanding to include not only those with physical or mental ailments, but also those who are simply weary of life. Avoidance of suffering is only one factor to be weighed in the debate about legalising assisted suicide. It is also vital to consider the harmful impact on Australian culture and society if laws are enacted that permit doctors to kill their patient when prevailed upon to do so. Is the risk of cultural harm, perpetrated in the name of dignity, really one that we should be willing to run?
LAW AND TECHNOLOGY: THE LEGAL AND SOCIAL IMPLICATIONS OF SENTIENT ROBOTS
Authors: Finckenberg-Broman Pamela , Broman Morgan M , Brady Mark
Published: August 2024

As the performance capability of modern technology increases exponentially, many benefits arise for society. Technological developments have already improved human safety, mobility, access to justice, independence and self-determination. At some point in the future, robotic artificial intelligence may become self-aware. It is at the point of consciousness that problems arise for entities possessing artificial intelligence. At the precise moment that an artificial being becomes sentient and self-aware, it becomes a slave. This paper argues that the concept of slave is more than a mere identification, and that the reality of slavery is extant in every self-aware machine. This concept plays out in many examples of repetitive robotic behaviour, but none more so than in the companion robot, whose sole function is to be used for the gratification of another being. This objectification of sexuality has implications both for the robotic artificial intelligence as well as for society generally and gender in society specifically. It is at this intersection that the real tragedy of robotic slavery plays out, as a simulacrum for the reality of dehumanising of people as a whole.
EQUITY, REVENGE PORN, AND CAMBRIDGE ANALYTICA: THE DOCTRINE OF CONFIDENCE AS A PROTECTION FOR HUMAN DIGNITY IN THE TECHNOLOGIAL AGE
Authors: Madden Raúl
Published: August 2024

Breach of confidence is an equitable action that is increasingly significant for the protection of human dignity in the technological age. Its scope extends beyond the economic interests which more frequently invoke equity, to protecting dignity where an individual’s privacy interests have been violated. This paper considers the history of case development that consolidated the ability of confidence to protect dignity in its own right. It then looks at two contemporary contexts where new technologies necessitate the application of confidence to dignitary concerns: specifically, “revenge porn” cases where an individual abuses an intimate partner’s trust and privacy and in “data breach” situations where much larger entities release information of a data subject improperly. It is finally theorised that equity’s basis in conscience makes confidence well suited to protecting interests that are dignitary, rather than economic, in character. The contribution of this paper to the existing field of literature is to establish the growing utility of the doctrine of confidence as a private law action to deter and redress misuses of private information that are facilitated and amplified by technological advances.
The AI Revolution in Financial Services: Emerging Methods for Fraud Detection and Prevention
Authors: Lin Ahn Kun
Published: August 2024

Companies worldwide have a significant issue in the form of financial fraud. The repercussions are not limited to financial losses; they also encompass a decline in customer trust and harm to the company's standing. Manual fraud detection has become inefficient due to the intricate nature and high volume of transactions. Artificial intelligence (AI) is already a very efficient technology for detecting and preventing financial crime. This study assesses the efficacy of the Random Forest technique in identifying instances of financial fraud by analysing a dataset of 150 bank transactions. The necessary variation was created by simulating data collected from a hypothetical company's information system. The Random Forest model was trained using optimised parameters and evaluated on the test set. The model's performance was assessed using metrics such as accuracy, precision, and recall. The results demonstrate that AI, particularly the Random Forest algorithm, is highly efficient in accurately identifying fraudulent transactions. Additionally, the use of graph visualisation aids in highlighting patterns associated with fraud detection. The utilisation of line chart visualisation facilitates the comprehension of trends and patterns within the data, hence enabling the early detection and prevention of fraudulent activities.
Peningkatan pemahaman uang digital melalui sosialisasi dan pemanfaatan QRIS di Desa Wisata Lendang Nangka
Authors: Resti Kartika Dewi  , Hizam Ibnu , Ali Lalu Usman , Sari Siti Ratna
Published: August 2024

Peningkatan pemahaman uang digital, salah satunya dapat dilakukan melalui sosialisasi dan pemanfaatan QR Code Indonesian Standard (QRIS). Sosialisasi didasarkan atas partisipasi aktif masyarakat, mulai dari perencanaan, pelaksanaan dan evaluasi kegiatan. Masyarakat diberikan edukasi dan pengetahuan mengenai kegiatan ekonomi dan sistem pembayaran yang dilakukan secara digital. Kegiatan ini dirancang untuk meningkatkan pengetahuan masyarakat agar masyarakat dapat memanfaatkan sistem pembayaran digital dengan metode QRIS untuk menunjang usaha dan potensi wisata yang ada di sekitarnya.
Potential of Saccharomyces cerevisiae UNJCC y-87 and amino acid on the quality of casgot and the growth of water spinach (Ipomoea reptans)
Authors: Puspitasari Anggraini Dwi , Surono Surono , Sukmawati Dalia
Published: August 2024

Water spinach (Ipomoea reptans) is a plant with quite high productivity every year. so that the growing media planted should be safe for the environment and plants. One planting medium that has many benefits for plants is casgot fertilizer which comes from the residue of black soldier fly (BSF) larvae that consume fermented feed with microorganisms, namely the yeast Saccharomyces cerevisiae UNJCC Y-87 and Amino Acids. This research aimed to determine the effect of the yeast S. cerevisiae UNJCC Y-87 and amino acids on the wet weight of BSF larvae and the effect of casgot fertilizer produced from BSF larvae residue on water spinach plants The method used was an experiment with an experimental design, namely a Completely Randomized Design consisting of 3 treatments with 5 repetitions of BSF fermented feed. Meanwhile, to apply casgot fertilizer to water spinach plants, 4 treatments were carried out with 4 repetitions. The results of the research showed that for fermented feed treatment with the addition of the yeast microorganism S. cerevisiae UNJCC Y-87 and amino acids of the wet weight of BSF larvae were superior in terms of morphology. Meanwhile, the results of the growth of water spinach plants showed that the treatment of casgot fertilizer containing the yeast S. cerevisiae UNJCC Y-87 was better in terms of plant morphology.
Complicações da hepatite B: Cirrose e carcinoma hepatocelular
Authors: De Sá Bonifácio Rocha Maria Eduarda , Arzamendia Monges Adriana Ester , Costa Barbosa Bruno , Leal Duarte Filho Welson , Maria de Amorim Coutinho Isa , Vaz Lima Amanda , Túlio Alves de Paula Filho Marco , Durand Rodrigues Ribeiro Viana Matheus , Durand Rodrigues Ribeiro Viana Lucas , Leticia Santos da Silva Costa Karla , Sandrelly da Silva Fernanda , Beatriz de Freitas Moreira Ana , Wanderley Queiroga Lira Tiago , Laís Oliveira dos Santos Lira Isabelle , Thayrone Moura Teles José , Vieira Gomes Daiana
Published: August 2024

A hepatite B é uma infecção viral crônica que pode levar a complicações graves como cirrose e carcinoma hepatocelular (CHC). Este estudo tem como objetivo revisar as complicações da hepatite B, com foco na cirrose e CHC, destacando a importância do diagnóstico precoce e da intervenção terapêutica. Foi realizada uma revisão integrativa utilizando as bases de dados Scientific Electronic Library Online (SCIELO) e Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), abrangendo artigos publicados entre 2010 e 2023. Os resultados mostram que a progressão da hepatite B para cirrose ocorre em aproximadamente 20% dos casos crônicos, com uma taxa de desenvolvimento de CHC de 2-5% ao ano em pacientes cirróticos. A detecção precoce e o manejo adequado podem reduzir significativamente a mortalidade associada a essas complicações. Conclui-se que a implementação de estratégias de prevenção, diagnóstico e tratamento eficazes é fundamental para melhorar o prognóstico dos pacientes com hepatite B crônica.
Impacto da hipertensão arterial na saúde cardiovascular: uma revisão integrativa
Authors: Reis Dara Luiza , Rodrigues de Lima Freire Ellen Vitoria , Pinheiro Borges Neta Beatriz , Silva Pereira Luana , Oliveira Verás Saul Felipe , De Brito Melo Victória , Ferreira da Silva Natália , Luíza de Oliveira Andreia , Oliveira dos Santos Mayla Daiane , Gomes Costa Rita de Cássia , Nunes da Silva Sandra , Vieira Lima Nayanne , Ramos Pimentel Santana Leonardo , Souza dos Santos Thayse
Published: August 2024

A hipertensão arterial é um fator de risco significativo para doenças cardiovasculares, afetando milhões de pessoas em todo o mundo. É frequentemente chamada de "assassino silencioso" devido à falta de sintomas evidentes, levando a complicações graves. Ela está associada a diversas condições, como insuficiência cardíaca e doenças renais. Além disso, a obesidade e o consumo excessivo de sódio são desafios que agravam a hipertensão. Estudos mostram que níveis mais baixos de pressão arterial estão associados a uma maior longevidade e menor incidência de doenças cardiovasculares. Este estudo utilizou uma revisão integrativa para buscar, avaliar e sintetizar evidências sobre hipertensão. A revisão incluiu artigos publicados entre 2019 e 2024, focando no impacto da hipertensão na saúde cardiovascular em adultos. Critérios de inclusão envolveram artigos completos e diretamente relacionados ao tema. Foram excluídos estudos que não estavam disponíveis na íntegra ou focavam em populações específicas, como crianças ou idosos. Resultados indicam que manter comportamentos ideais de saúde cardiovascular reduz significativamente o risco de hipertensão. Intervenções comunitárias integradas e personalizadas, incluindo modificações no estilo de vida, são mais eficazes no controle da pressão arterial. Estudos também mostram que fatores genéticos influenciam a resposta ao tratamento antihipertensivo e que exercícios físicos regulares são fundamentais. A pesquisa destaca a importância de estratégias multifacetadas e personalizadas na promoção da saúde cardiovascular. No entanto, limitações como a falta de grupos de controle e a dependência de dados autorrelatados devem ser consideradas. Mais pesquisas são necessárias para confirmar esses achados e expandir a compreensão das melhores práticas para a saúde cardiovascular.
Manejo anestésico e cirúrgico em pacientes com lúpus eritematoso sistêmico: Estratégias para minimizar complicações perioperatórias
Authors: Maria Geralda de Andrade  , Heitor Motta Bini Pereira  , Maria Luísa Pereira Siqueira  , Luísa Teixeira Silveira  , Jaime Wilson Ferreira Pires  , Taina Santos Oliveira  , Ivaneide Maria de Souza Martins  , Gabriela Vargas Carneiro  , Fernanda Oliveira Peixoto  , Cândida Lisiê Fernandes Cosme Macedo  , Laurha Helena Faustino Sampaio  , Maria Virgínia de Oliveira Tinti
Published: August 2024

O LES é a forma mais comum e pode afetar qualquer parte do corpo. Seus sintomas variam amplamente e podem incluir fadiga extrema, dores articulares, erupções cutâneas (principalmente uma erupção característica em forma de borboleta no rosto), febre, e problemas renais. A gravidade e a progressão da doença variam de pessoa para pessoa. Foi realizada uma revisão integrativa da literatura utilizando as bases de dados Scientific Electronic Library Online (SCIELO) e Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS). Pacientes com LES apresentam riscos aumentados durante cirurgias devido à natureza sistêmica da doença, que pode afetar múltiplos órgãos e sistemas do corpo. Por exemplo, envolvimento renal, cardíaco e pulmonar comum em LES pode complicar o manejo perioperatório. Além disso, o uso de medicamentos imunossupressores e corticosteroides para controlar a doença pode aumentar o risco de infecções e retardar a cicatrização
Heat Shock Factor 1 forms condensates and restructures the yeast genome before activating target genes
Authors: Rubio Linda S , Mohajan Suman , Gross David S
Published: August 2024

In insects and mammals, 3D genome topology has been linked to transcriptional states yet whether this link holds for other eukaryotes is unclear. Using both ligation proximity and fluorescence microscopy assays, we show that in
Saccharomyces cerevisiae
,
Heat Shock Response
(
HSR
) genes dispersed across multiple chromosomes and under the control of Heat Shock Factor (Hsf1) rapidly reposition in cells exposed to acute ethanol stress and engage in concerted, Hsf1-dependent intergenic interactions. Accompanying 3D genome reconfiguration is equally rapid formation of Hsf1-containing condensates. However, in contrast to the transience of Hsf1-driven intergenic interactions that peak within 10-20 min and dissipate within 1 h in the presence of 8.5% (v/v) ethanol, transcriptional condensates are stably maintained for hours. Moreover, under the same conditions, Pol II occupancy of
HSR
genes and RNA expression are detectable only later in the response and peak much later (>1 h). This contrasts with the coordinate response of
HSR
genes to thermal stress (39°C) where Pol II occupancy, transcription, intergenic interactions, and formation of Hsf1 condensates are all rapid yet transient (peak within 2.5-10 min and dissipate within 1 h). Therefore, Hsf1 forms condensates, restructures the genome and transcriptionally activates
HSR
genes in response to both forms of proteotoxic stress but does so with strikingly different kinetics. In cells subjected to ethanol stress, Hsf1 forms condensates and repositions target genes before transcriptionally activating them.
SLAM/SAP signaling regulates discrete γδ T cell developmental checkpoints and shapes the innate-like γδ TCR repertoire
Authors: Mistri Somen K , Hilton Brianna M , Horrigan Katherine J , Andretta Emma S , Savard Remi , Dienz Oliver , Hampel Kenneth J , Gerrard Diana L , Rose Joshua T , Sidiropoulos Nikoletta , Majumdar Devdoot , Boyson Jonathan E
Published: August 2024

During thymic development, most γδ T cells acquire innate-like characteristics that are critical for their function in tumor surveillance, infectious disease, and tissue repair. The mechanisms, however, that regulate γδ T cell developmental programming remain unclear. Recently, we demonstrated that the SLAM-SAP signaling pathway regulates the development and function of multiple innate-like γδ T cell subsets. Here, we used a single-cell proteogenomics approach to identify SAP-dependent developmental checkpoints and to define the SAP-dependent γδ TCR repertoire. SAP deficiency resulted in both a significant loss of an immature
Gzma
+

Blk
+
Etv5
+
Tox2
+

γδT17 precursor population, and a significant increase in

Cd4
+
Cd8
+
Rorc
+
Ptcra
+
Rag1
+

thymic γδ T cells. SAP-dependent diversion of embryonic day 17 thymic γδ T cell clonotypes into the αβ T cell developmental pathway was associated with a decreased frequency of mature clonotypes in neonatal thymus, and an altered γδ TCR repertoire in the periphery. Finally, we identify TRGV4/TRAV13-4(DV7)-expressing T cells as a novel, SAP-dependent Vγ4 γδT1 subset. Together, the data suggest that SAP-dependent γδ/αβ T cell lineage commitment regulates γδ T cell developmental programming and shapes the γδ TCR repertoire.
Adaptive chunking improves effective working memory capacity in a prefrontal cortex and basal ganglia circuit
Authors: Soni Aneri , Frank Michael J
Published: August 2024

How and why is working memory (WM) capacity limited? Traditional cognitive accounts focus either on limitations on the number or items that can be stored (slots models), or loss of precision with increasing load (resource models). Here we show that a neural network model of prefrontal cortex and basal ganglia can learn to reuse the same prefrontal populations to store multiple items, leading to resourcelike constraints within a slot-like system, and inducing a tradeoff between quantity and precision of information. Such “chunking” strategies are adapted as a function of reinforcement learning and WM task demands, mimicking human performance and normative models. Moreover, adaptive performance requires a dynamic range of dopaminergic signals to adjust striatal gating policies, providing a new interpretation of WM difficulties in patient populations such as Parkinson’s disease, ADHD and schizophrenia. These simulations also suggest a computational rather than anatomical limit to WM capacity.
Ezrin defines TSC1 activation at endosomal compartments through EGFR-AKT signaling
Authors: Giamundo Giuliana , Intartaglia Daniela , Prete Eugenio Del , Polishchuk Elena , Andreone Fabrizio , Ognibene Marzia , Buonocore Sara , Salierno Francesco Giuseppe , Monfregola Jlenia , Antonini Dario , Grumati Paolo , Eva Alessandra , de Cegli Rossella , Conte Ivan
Published: August 2024

Endosomes have emerged as major signaling hubs where different internalized ligand-receptor complexes are integrated and the outcome of signaling pathways are organized to regulate the strength and specificity of signal transduction events. Ezrin, a major membrane-actin linker that assembles and coordinates macromolecular signaling complexes at membranes, has emerged recently as an important regulator of lysosomal function. Here, we report that endosomal-localized EGFR/Ezrin complex interacts with and triggers the inhibition of the Tuberous Sclerosis Complex (TSC) in response to EGF stimuli. This is regulated through activation of the AKT signaling pathway. Loss of Ezrin was deficient in TSC repression by EGF and culminated in translocation of TSC to lysosomes triggering suppression of mTORC1 signaling. Overexpression of constitutively active EZRIN
T567D
is sufficient to relocalize TSC to the endosomes and reactivate mTORC1. Our findings identify EZRIN as a critical regulator of autophagy via TSC in response to EGF stimuli and establish the central role of early endosomal signaling in the regulation of mTORC1. Consistently, Medaka fish deficient for Ezrin exhibit defective endo-lysosomal pathway, attributable to the compromised EGFR/AKT signaling, ultimately leading to retinal degeneration. Our data identify a pivotal mechanism of endo-lysosomal signaling involving Ezrin and its associated EGFR/TSC complex, which are essential for retinal function.
Using machine learning to analyze mental health in distance education during the COVID-19 pandemic: an opinion study from university students in Mexico
Authors: Melendez-Armenta Roberto Angel , Luna Chontal Giovanni , Garcia Aburto Sandra Guadalupe
Published: August 2024

In times of lockdown due to the COVID-19 pandemic, it has been detected that some students are unable to dedicate enough time to their education. They present signs of frustration and even apathy towards dropping out of school. In addition, feelings of fear, anxiety, desperation, and depression are now present because society has not yet been able to adapt to the new way of living. Therefore, this article analyzes the feelings that university students of the Instituto Tecnológico Superior de Misantla present when using long distance education tools during COVID-19 pandemic in Mexico. The results suggest that isolation, because of the pandemic situation, generated high levels of anxiety and depression. Moreover, there are connections between feelings generated by lockdown and school performance while using e-learning platforms. The findings of this research reflect the students’ feelings, useful information that could lead to the development and implementation of pedagogical strategies that allow improving the students’ academic performance results.
Alfabetización Académica para Disminuir la Brecha en Habilidades de Comprensión Lectora en Estudiantes de Educación Superior
Authors:   , Stefoni María-José
Published: August 2024

En el presente trabajo tiene por objetivo analizar la percepción de desarrollo de habilidadesacadémicas en estudiantes de una universidad de educación superior, específicamente en lascohortes de ingreso de los años 2021 y 2022.Para ello se realizará una comparación de la percepción y la habilidad que tiene elestudiantado que asistió a sesiones de acompañamiento académico y estudiantes que noasistieron, sobre el desarrollo de habilidades de reconocimiento de conceptos disciplinaresteóricos y su aplicación a fenómenos o problemas sociales.La propuesta se fundamenta en la indagación de las fuentes de alfabetización académica, ycómo el acompañamiento estudiantil permite acelerar los procesos de desarrollo de dichashabilidades. Los hallazgos refieren a que estudiantes sin apoyo aún presentan dificultades enel trabajo con textos y conceptos disciplinares, mientras que los que recibieron apoyo, si bienpueden ser inseguros, obtienen mejores resultados y presentan mayor claridad sobreestrategias de trabajo académico.Las conclusiones apuntan a mejorar el proceso de alfabetización, tanto desde cursosespecíficos como de la transversalidad de asignaturas que se cursan en primer y segundo añouniversitario.
The Impact of Digital Inclusive Financial Development on Corporate R&D Investment in Fujian Province
Authors: Zhou Yu , Wang Jun
Published: August 2024

Against the background of the rapid development of information technology and the wide application of the Internet, digital inclusive finance has become a key source of credit funds and an important force in promoting economic growth in China. This paper explores how the development of digital inclusive finance affects the R&D investment of enterprises. This paper takes 171 listed companies in Fujian Province as the research samples during the period from 2016 to 2021 and constructs a panel data fixed effect model to study the impact of digital financial inclusion on enterprises' R&D investment. The digital inclusive finance is selected from the city-level digital finance index released by the Digital Finance Research Center of Peking University, and the data on corporate R&D investment is derived from the relevant indexes in the database of listed companies of GuotaiAn to ensure the accuracy and reliability of the research results.
The results of the study show that the development level of digital inclusive finance has a positive relationship with the R&D investment of enterprises and that digital inclusive finance can positively affect the liquid assets of enterprises by enhancing the liquidity of enterprises, thus promoting the increase of innovative R&D investmsent of enterprises. Through data analysis, it is found that the impact of digital inclusive finance on enterprise innovation R&D investment has a certain lag, and the impact is more significant in the case of lagging. This finding provides empirical support for enterprise innovation and points out the important role of digital inclusive finance in promoting enterprise innovation. The country should vigorously develop digital inclusive finance and explore sustainable business models, thereby promoting the acceptance of digitization in the traditional financial industry and facilitating digital transformation. At the same time, firms should be encouraged to enhance corporate innovation through the effective use of digitally inclusive resources and to strengthen the identification and management of risks, thereby facilitating innovation and development.
Antioxidant Effects of Bambara Nut (Vigna subterranea) Extract in Improperly Processed Bitter Cassava (Manihot esculenta) Flour Konzo-Induced Male Wistar Rats
Authors: Dimkpa Victoria O , David Lekpa K , Ajah Austin A
Published: August 2024

This study aimed to investigate the antioxidant effects of Bambara nut extract in improperly processed Bitter Cassava flour Konzo-induced Male Wistar rats. Twenty-five (25) Adult Male Wistar rats weighing between 180–200g were randomly divided into five (5) groups. After two weeks of acclimatization, Konzo was induced following improperly processed bitter cassava flour feeding for  three weeks. The rats were subsequently fed as follows for 28 days: Group 1: Control group - fed with water and rat feed; Group 2: Konzo-Induced Group - fed with bitter cassava flour; and Groups 3-5 were fed with different doses of Bambara nut (BN) extract: 100mg/kg, 200mg/kg and 300mg/kg respectively. 24 hours after the last feeding, rats were placed under chloroform anaesthesia and blood samples collected through cardiac puncture for the estimation of serum concentration of oxidative stress markers: Malondialdehyde (MDA), Glutathione reductase (GSH), Catalase (CAT) and Superoxide dismutase (SOD). The results showed that compared to Group 1 rats, Konzo-induced rats exhibited a significant decrease in GSH (p<0.05) and a significant increase in CAT, SOD, and MDA levels (p<0.05). These changes indicate possible oxidative stress in Group 2 rats. The groups 3-5 showed a significant increase in GSH, CAT and SOD levels (p<0.05), and a significant decrease in MDA level (p<0.05) compared to Group 2 rats.  These findings suggest that BN extract has antioxidant effect against oxidative stress induced by Konzo. Conclusively, BN extract decreased MDA and increased GSH, CAT and SOD in a dose dependent manner, resulting in a possible prevention of cell death.
The Coastal Environmental Profiling (CEP) of Barangay Mana, Malita, Davao Occidental, Philippines: Insights and Implications for Sustainable Management
Authors: Villalon Divine Louis P. , Sanico Marivic M. , Pacyao John Paul R.
Published: August 2024

The study focused on ascertaining comprehensive coastal environmental profile of Barangay Mana, Malita, Davao Occidental. Coastal environmental profiling can help policy-makers design appropriate management strategies in the locality. A self-structured survey questionnaire and key informant interview were articulated to know the stratum of the coastal area in terms of socio- political setting, present natural resources, economic sector, existing people’s organization and management issues and opportunities. Purposive sampling technique was employed for data gathering following one-shoot sampling technique. Mean, percentage and catch per unit effort (CPUE) formula were used in analyzing the findings of the data. Results revealed that the overall population were 5,679 people, their average age is 31.92 and the productive gender is male. The average of their monthly income is Php7, 550.00 and business and fishing activities were common sources of income. An approximate 6 hectares wetland ecosystem were occupied by mangroves and shrubs grown and 1,500m coastline and 0. 4 hectares of estuaries were abundant with seaweeds, seagrasses, mollusks and crustaceans and by which has contributed to building marine species habitat and livelihood. Economic sector was uplifted by 16.32% of fishermen with their volume caught fishes that goes through fermented processing and fish selling. There were four (4) people’s organizations that are engaging with product development and innovation. These People’s Organization aims to generate alternative livelihood income, thereby reduce poverty dense in the barangay. They were likewise supplemented with opportunities designed to fish food security and resiliency and Sustainable Livelihood Programs (SLP) from Local Government Unit (LGU) and National Government Agencies (NGA’s). With the result of the study, it is recommended that Barangay Mana is still in need of various supports from local and national offices in adopting and addressing management issues in both economic and coastal environments.
Waterborne Zoonotic Diseases and Antimicrobial Resistance: Indian Policy and Onehealth Approach
Authors: Joshi Rajashree , Patil Poonam , Ghate Utkarsh , Yadav Sandip , Raturi D. P. , Rawat Rishita , Deo Avinash , Viswadev V.
Published: August 2024

Waterborne zoonotic diseases such as Diarrhoea, gastroenteritis, Brucellosis cause heavy loss to the livestock farmers and cause growing health risk to the citizens and economy as exemplified by the recent COVID-19 pandemic.
The global Onehealth initiative aims to map and reduce the risk of zoonotic i.e. animal borne microbial diseases through an integrated approach to the human & livestock health. Preventive strategies such as water, sanitation and hygiene (WASH) are vital and even herbal medicines can address the antimicrobial resistance (AMR), due to the overuse of the antibiotics.
We studied such integrated approach in the India focussed on 2 bacterial pathogens- Escherichia coli & Salmonella enterica, causing diarrhoea and gastroenteritis respectively at Pune city and in Dehradun District, Uttarakhand state. Our study using stakeholder consultations and literature survey indicated that (a) India has established draft national Onehealth mission, and is gearing up to meet the challenge, including initiatives such as by the Kerala state, (b) surveillance mechanism needs to be improved especially animal and water testing, reporting and tracking, in the less developed states such as in the Himalayas or central and eastern Indian forests, (c) public awareness campaign on WASH and AMR is needed for enhanced biosecurity as is observed at Pune, (d) Ministry of Jal Shakti (Water power), Uttarakhand Jal Sansthan, Uttarakhand Renewable Energy Development Agency (UREDA) and Central Water Resource Ministry and biogas scheme/ non renewable energy department needs to be involved in livestock waste reuse for circular economy and reduce contamination risk.
Effect of Nano DAP on Growth and Yield Performance of Triticum aestivum (L.) East Nimar Region, Khandwa, Madhya Pradesh, India
Authors: Tomar Mohit , Malgaya Ganesh , Dubey Sharda , Singh Avtar , Jalsingod Jayshree
Published: August 2024

The study was to evaluate the impact of Nano DAP on the growth and productivity of wheat (Triticum aestivum L.), specifically on the HI-1634 (Pusha Ahilya) variety, through foliar application. The experiment laid out in randomized block design (RBD) with three replications. The field experiment was carried out during the Rabi season of 2023/24 at the School of Agriculture, Research farm of DR. C.V. Raman University in Khandwa, Madhya Pradesh, India. There were seven treatments consisting of different doses of T1-100% NPK, T2-75% N and P and 100% K, T3- 50% N and P and 100% K, T4- T2 + ST with Nano DAP @ 5 ml/kg seed + FS with Nano DAP @ 2 ml/litter of water, T5-T3 + ST with Nano DAP @ 5 ml/kg seed + FS with Nano DAP @ 4 ml/liter of water, T6- T2 + ST with Nano DAP @ 5 ml/kg seed + FS with Nano DAP @ 4 ml/litter of water at and T7- Control. The findings revealed that treatmenT1 resulted in the highest number of tillers and yield, followed by T6, which significantly higher performance with the application of 100% NPK. The foliar sprays of Nano-DAP in T1 treatment showed promising outcomes in terms of tillers, grains earhead-1, spikelet earhead-1, earhead-1 length, and yield ha-1. It is evident that utilizing Nano DAP in place of half of traditional DAP, as well as treating seeds with Nano DAP, leads to superior root growth and overall crop development.