bluuebunny/crossref_metadata_2025 huggingface dataset:
STUDI IN SILICO SENYAWAhMETABOLIThSEKUNDER DAUN SIRIH HIJAU (Piper betle L) SEBAGAI INHIBITOR ENZIM MAINhPROTEASE (Mpro) PADA SARS-CoV-2
Authors: Parhan Naja Akhmad , Andika  , Mi’rajunnisa
Published: June 2022

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) adalah virus penyebab COVID-19. Salah satu target potensial untuk pengobatan SARS-CoV-2 ialah Main protease (Mpro). Daun sirih hijau (Piper betle L.) adalah tanaman yang terbukti secara ilmiah mempunyai efek sebagai antibakteri dan antivirus. Bagian dari tanaman sirih (Piper betle L.) seperti akar, biji, dan daun bermanfaat untuk pengobatan, tetapi yang paling umum digunakan adalah bagian daun. Tujuan penelitian ini ialah untuk mengetahui potensi dan interaksi senyawa metabolit sekunder daun sirih hijau sebagai antivirus penghambat Mpro pada SARS-CoV-2 dengan protein ID: 5R84 menggunakan uji penambatan molekul. Pengujian ini meliputi penambatan molekul, pengujian Lipinski dan prediksi ADMET. Metode yang digunakan berbasis oriented docking dengan kompleks protein ligand dibuat semi fleksible docking menggunakan software Autodock4. Hasil secara keseluruhan diperoleh dua puluh lima senyawa uji dari metabolit sekunder daun sirih hijau berpotensi sebagai penghambat Mpro dan senyawa uji yang mempunyai nilai energi binding (energi ikat bebas (?G)) terbaik yang berasal dari Piperine sebesar - 8,27..kcal/mol, disusul oleh Piperlonguminine sebesar..-8,07..kcal/mol serta Kaempferol - 7,95..kcal/mol. Piperine sendiri diprediksi memiliki absorbsi yang bagus, distribusi pada VDss tinggi, tetapi bukan subtrat dan inhibitor dari CYP 450, memiliki total klerens yang tinggi, berpotensi menimbulkan iritasi pada kulit dan toksik pada uji protozoa T.pyriformis. Residu asam amino HIS 41, MET 49, PHE 140, HIS 163, MET 165, GLU 166, ASN 142, ARG 188, dan GLN 189 banyak berkontibusi terbentuk ikatan hydrogen.
WORKING PERFORMANCE PRADHAN MANTRI JANDHAN YOJANA (PMJDY) IN INDIA – A STUDY
Authors:   Associate Professor  Department of Commerce, Annamalai University, Annamalai Nagar- 608 002,  Tamil Nadu, India, RAMACHANDRAN R , SATHIYAMOORTHY D ,   Ph.D Research Scholar Department of Commerce, Annamalai University, Annamalai Nagar- 608 002,  Tamil Nadu, India
Published: June 2022

The article endeavors to check the recent trends in money inclusion in Asian nation with special relevancy Pradhan Mantri Gregorian calendar month Dhan Yojana (PMJDY), light its key areas and suggests ways to confirm most money inclusion for the poor and unbanked areas. This paper focuses on the role of monetary inclusion in strengthening the Indian economy. For analyzing such facts secondary sources of knowledge has been collected. it's not greatly correct time to judge the PMJDY theme that is simply in its child stage. however a shot has been created during this paper to research the performance to this point, benefits, difficulties and future prospects of the theme. Keywords: Financial Inclusion, Sustainable Economic Growth, PMJDY, Economic Growth
Phytochemical analysis, antioxidant and anti-inflammatory activity of Leaf extracts of Merremia emarginata
Authors:   Associate Professor, P.Rami reddy Memorial College of Pharmacy, Kadapa, Andhra Pradesh, India., Vasavi devi Dasari
Published: June 2022

The plant Merremia emarginata was extracted with ethanol and from the ethanolic extract, ethyl acetate fraction was prepared and to the above products preliminary phytochemical studies was performed and it shows the presence of flavonoids, steroids, terpenoids, tannins, carbohydrates, amino acid and glycosides. To the ethanolic extract of Merremia emarginata leaves and ethyl acetate fraction TLC was performed in various mobile phases and detected by using UV chamber, concentrated sulphuric acid and iodine chamber. The Rf values were noted. It was found that the extract and fractions has both fluorescent and non-fluorescent compounds. The column chromatography was performed for the Ethyl acetate fractions in normal phase by increasing the polarity. The fractions were collected and conducted the TLC. So, at the fraction of (Hexane: Ethyl Acetate (6:4)), single spot was observed. The EEME and HEAFME were screened for their antiinflammatory and antioxidant activities. Keywords: Merremia emarginata, Column chromatography, Anti-inflammatory and Antioxidant activity
Awareness on Efficacy and Side Effects of Female Contraceptives
among Nursing Undergraduates at KIU, Sri Lanka
Authors: Razzaag B. A , Mizna F , Shaamila H , Saffath H , Kanchana K. T. G.
Published: June 2022

Unplanned pregnancies have rapidly emerged as a social issue that significantly degrades the quality of life of parents and children. Therefore, nurses, being a vital part of the health system, should be well-aware regarding contraceptive methods. The objective of the study was to assess awareness of safety, efficacy, and side effects of female contraceptives among nursing undergraduates at KAATSU International University (KIU). Descriptive cross-sectional study was conducted among 362 undergraduate nurses studying at KIU, Sri Lanka, using a convenient sampling method. The data were collected using a self-administered pre-tested questionnaire that consisted of four parts; demographic variables, safety, efficacy and side effects related questions. The data was analyzed using descriptive statistics and the Pearson Chi-square test. Out of total, 74.6% (n=270) of the participants had an average awareness regarding different types of female contraceptives and 74.5% (n=270) had average awareness (40-59.9%) regarding major side effects of female contraceptives while the awareness regarding efficacy of different contraceptive methods was found to be only 37% (n=134) related to female condom. Overall, the study revealed that majority of nurses had an average awareness regarding the safety and main side effects of female contraceptive methods, further they had a had a low level of awareness on efficacy of female contraceptive methods. Therefore, it is important to enhance nurses’ awareness related to modern female contraceptive methods.
Extending Simulation Decomposition Analysis into Systemic Risk Planning for Domino-Like Cascading Effects in Environmental Systems
Authors:   School of Business and Management, LUT University, Yliopistonkatu 34, Lappeenranta 53850, Finland, Kozlova M. , Yeomans J. S. ,   OMIS Area, Schulich School of Business, York University, 4700 Keele Street Toronto, ON M3J 1P3, Canada
Published: June 2022

In interconnected environmental systems, the innocuous failure of one component can sometimes trigger a subsequent domino-like effect resulting in a cascading collapse of the entire system. Risk analysis in “real world” contexts frequently requires the need to simultaneously contrast numerous uncertain factors and difficult-to-capture dimensions. Monte Carlo simulation modelling has often been employed to integrate uncertain inputs and to construct probability distributions of the resulting outputs. Visual analytics and data visualization can be used to support the processing, analyzing, and communicating of the influence of multi-variable uncertainties on the decision-making process. In this paper, the novel Simulation Decomposition (SimDec) analytical technique is extended into complex assessments of cascading risk analysis and used to quantitatively examine situations involving potentially catastrophic, dominolike collapses of an entire system. SimDec analysis proves to be beneficial due to its ability to reveal interdependencies in complex models, its ease of decision-maker perception, its visualizable analytic capabilities, and its significantly lower computational burdens. The case example visually demonstrates that when a system collapse is a low-probability/high-impact event, more expensive, reactive policies minimize the overall value loss under conditions of system survival, while more proactive policies enable better loss prevention under system survival. However, proactive approaches significantly decrease the likelihoods and magnitudes of losses for scenarios resulting from the collapse of the system. Such findings would not have been revealed without the visualization provided by SimDec.
ANALISIS FRAMMING PEMBERITAAN TENTANG PERJUANGAN NAKES WANITA MENGHADAPI COVID-19 DI TIRTO.ID, RADARMOJOKERTO.ID, DAN TEMPO.CO
Authors: Afraita Ariyan
Published: June 2022

Pemberitaan tentang pandemi covid-19 sudah sangat banyak terdengar di telinga kita. Mulai dari berita di televisi, radio, bahkan di media sosial. Pandemi ini mulai ada di Indonesia pada tahun 2020 lalu tepatnya pada bulan Maret. Sampai sekarang tahun 2021 pun virus ini belum kunjung mereda. Ada saja lonjakan korban yang terpapar virus mematikan ini. Pemberitaan dari virus ini tidak terlepas dari perjuangan dan pengorbanan tenaga kesehatan yang turut membantu bahkan menjadi garda terdepan dalam melawan virus covid-19. Banyak pula tenaga kesehatan yang menjadi korban bahkan sampai meninggal karena paparan virus ini. Studi ini menganalisis bagaimana sudut pandang dan cara media online mengkonstruksi berita tersebut, peneliti memilih Tirto.id, Radarmojokerto.id, dan Tempo.co sebagai objek penelitian dengan menggunakan analisis framing Zhongdan Pan dan Gerald M. Kosicki. Hasilnya ternyata ketiga media online tersebut memiliki gaya dan karakteristik tersendiri dalam menyajikan berita.
KEBIJAKAN PEMERINTAH INDONESIA DALAM MENANGANI PEREKONOMIAN MASYARAKAT PADA KONDISI PANDEMI COVID-19
Authors: Ikmal Novita Maulida , Noor Machdian
Published: June 2022

Sepanjang tahun 2020 dunia telah digemparkan dengan munculnya virus baru yang menjangkit dunia saat ini yaitu Coronaviruses (CoV). Virus tersebut memiliki nama ilmiah COVID-19. Pandemi COVID-19 juga memberikan dampak cukup besar terhadap investasi yang membuat masyarakat akan memilih untuk sangat hati-hati dalam membeli barang bahkan untuk melakukan investasi. Pemerintah juga menghimbau agar masyarakat menerapkan social distancing seperti work from home, dan beribadah dari rumah. Penelitian ini menggunakan teori analisis kebijakan untuk mengungkapkan kebijakan pemerintah dalam menangani perekonomian masyarakat. Penulisan artikel ini merupakan penelitian pustaka (library research) dengan metode kualitatif yang bersifat menjelaskan sesuatu berdasar pada data dan angka yang dinarasikan dalam kalimat. Hasil dari penelitian ini mendapatkan beragam kebijakan yang dilaksanakan oleh pemerintah sebagai upaya menekan penyebaran COVID-19, diantaranya adalah kebijakan preventif, promotif dan jaring pengaman sosial. Selain itu, pemerintah juga berupaya untuk meringankan perekonomian masyarakat akibat adanya pandemi COVID-19 dengan dibentuknya Program Keluarga Harapan, Bantuan Pangan Non-Tunai, Kartu Prakerja, Bantuan Subsidi Listrik. Pemerintah juga menganggarkan dana alokasi dan memberikan keringanan kredit untuk pekerja sektor informal dan pelaku UMKM.
PEMBERATAN PIDANA BAGI PELAKU PEMERKOSAAN HUBUNGAN SEDARAH (INCEST)
Authors: Afifah Wiwik , Luciana Sari Nike
Published: June 2022

Kehidupan masyarakat di Indonesia tergantung dari kualitas keluarga dan bagaimana mereka menjamin atau memenuhi hak pada anak-anak nya, namun sayang nya banyak terjadi kasus kekerasan seksual dalam rumah tangga yaitu Incest. Incest adalah suatu perbuatan kekerasan seksual dilakukan oleh orang yang memiliki hubungan sedarah. Penulisan ini membahas tentang pemberatan pidana pada pelaku incest dalam peraturan di Indonesia. Penelitian ini menggunakan metode yuridis normative tentang tindak pidana incest yang pemberatan pidana nya belum diatur secara khusus. Pengaturan di KUHP yang selama ini ada tidak menunjukkan pemberatan, namun hukuman pidanan di Undang-undangn pelrindungan anak memberikan hukuman maksimal kepad apelaku, begitu pula dengan Undang-undang KDRT. Hal ini merupakan kemajuan karena pelaku adalah orang terdekat yang harusnya melindungi korban. Selain itu, harusnya kekerasan skesual incest juga diatur dalam rancangan undang-undang kekerasan sekesual.
РАЗВИТИЕ ИНТЕЛЛЕКТУАЛЬНОГО КАПИТАЛА И УПРАВЛЕНИЕ ИМ В СОВРЕМЕННЫХ КОМПАНИЯХ
Authors: Карпенко О. А.
Published: June 2022

Работа посвящена изучению вопросов развития интеллектуального капитала и управления им в условиях современного развития экономики и общества. Развитие интеллектуального капитала рассматривается на основе его функционирования в производственных отношениях и в научной сфере путем построения научной и преподавательской карьеры. Рассматриваются факторы, способствующие развитию талантов человека. Приводятся причины для написания научных статей современными учеными и аспирантами. Наряду с этим в статье указываются существующие в настоящее время этапы развития научной карьеры. Рассматривается вопрос управления интеллектуальным капиталом, человеческие умения и навыки, которые требуются для этого: когнитивные способности, личные и лидерские качества, навыки, относящиеся к конкретной области, психосоциальные навыки. Данные качества и навыки пригодятся человеку и в социальной деятельности и общественной жизни. Также в работе указываются современные социальные и общественные институты развития.
ЭКОНОМИЧЕСКИЕ САНКЦИИ КАК ИНСТРУМЕНТ СДЕРЖИВАНИЯ ЭКОНОМИЧЕСКОГО РОСТА В УСЛОВИЯХ ЦИФРОВИЗАЦИИ ЭКОНОМИКИ
Authors: Домагальская И. М. , Тищенко А. О. , Шилин В. А.
Published: June 2022

В настоящее время драйвером экономического роста выступает развитие цифровых технологий. Однако, сегодня Россия сталкивается с негативным воздействием совокупности факторов, которые способствуют возникновению новых рисков, существенно замедляющих темпы цифровой модернизации экономики и обеспечения экономического роста. Наиболее сильное воздействие на развитие экономики оказывают санкции. Поэтому антисанкционная политика, в том числе в сфере цифровых технологий, проводимая правительством России определяет перспективы дальнейшего экономического роста.
РОССИЙСКО-БЕЛОРУССКОЕ СОТРУДНИЧЕСТВО
НА ДАЛЬНЕМ ВОСТОКЕ: СОСТОЯНИЕ И ПЕРСПЕКТИВЫ
Authors: Толканева О. Г. , Апханова Е. Ю. , Бирюкова Л. В. , Синюков В. А. Синюков В. А. Синюков В. А.
Published: June 2022

Статья посвящена вопросам торгово-экономического сотрудничества Республики Беларусь и Дальневосточного региона. Авторами осуществлён анализ внешнеторгового оборота ДВО и Республики Беларусь. Представленные данные дают характеристику динамики экспорта дальневосточных регионов за последние 5 лет, а также импорта в ДВФО из Республики Беларусь. Приведена товарная структура внешнеторгового оборота в 2021 г. В работе дан анализ экспорта в Республику Беларусь и импорта из неё в разрезе регионов Дальнего Востока за период с 2017 по 2021 гг. На основании данных таможенной статистики рассчитан рейтинг регионов ДВФО в совокупном экспорте и импорте в 2018 и 2021 гг., что позволило сделать выводы об изменении доли региона во внешнеторговом обороте с Республикой Беларусь.
ТЕНДЕНЦИИ РАЗВИТИЯ ТРАНСПОРТНОЙ ЛОГИСТИКИ
В ЦИФРОВОЙ ЭКОНОМИКЕ
Authors: Степанова Е. Н. , Беляева Е. Р.
Published: June 2022

Транспорт занимает особое место в экономике страны. Его историческая, экономическая, социальная и политическая роль огромна. Именно он обеспечивает экономическую целостность огромного государства, позволяет связывать все регионы страны в единое целое, служит одной из основ национальной безопасности. На территории России сложилась одна из самых крупных и сложных транспортных схем, осуществляющая многоплановые связи на основе изготовленных технических средств, сформированных путей сообщения и налаженной службе перевозок. Статья посвящена рассмотрению основных тенденций развития транспортной логистики в цифровой экономике.
ОНЛАЙН И ОФЛАЙН В ФИРМЕННОЙ ТОРГОВЛЕ ПРОИЗВОДИТЕЛЕЙ В УСЛОВИЯХ ЦИФРОВОЙ ЭКОНОМИКИ
Authors: Артеменко Т. В.
Published: June 2022

Важной составляющей большинства бизнес-моделей являются каналы сбыта, в первую очередь многоканальность, в полномасштабной модели – омниканальность. В условиях цифровой экономики производители в фирменной торговле начинают использовать новые бизнес-модели, в частности, отдельные бизнес-модели электронной коммерции. Основываясь на данных о темпах развития онлайн-торговли, первоначально высказывались предположения о негативных последствиях данного процесса в отношении офлайн-торговли. Однако практическая реализация новых бизнес-моделей продаж (офлайн-, онлайн-торговля) дала развитие фирменной торговле производителей товарами потребительского и производственного назначения. В статье указаны отдельные причины развития каналов продаж, в том числе за счет онлайн-каналов, в частности, реализация стратегии развития предприятия, следование за тенденциями рынка, форс-мажорные обстоятельства, возникновение проблем в стандартных каналах сбыта. Однако применение цифровых бизнес-моделей в фирменной торговле производственных предприятий связано с рядом проблем.
РАЗВИТИЕ БИЗНЕС-МОДЕЛЕЙ ЭЛЕКТРОННОЙ ТОРГОВЛИ
В РОССИИ
Authors: Золотова Я. В.
Published: June 2022

В настоящее время рынок электронной торговли в России в целом сформировался и перешел в стадию стабильного развития. В статье описываются фазы развития электронного рынка в России, по которым можно сделать вывод об уровне зрелости цифровой торговли. Рынок электронной торговли определяется также степенью развития и использования различных типов бизнес-моделей. Сегодня существует более десятка разновидностей бизнес-моделей электронной коммерции, которые зависят от схемы взаимодействия продавца и покупателя.
ТРАНСФОРМАЦИЯ ФИНАНСОВО-ТЕХНОЛОГИЧЕСКОЙ ОТРАСЛИ В РОССИИ
Authors: Мартынов В. В. , Мартынова И. С.
Published: June 2022

Статья посвящена трансформации и цифровизации финтеха в России. Освящены особенности взаимодействия банков и финтех-компаний в процессе внедрения финтеха в банки. Перечислены некоторые инновационные финансовые технологии, используемые при продаже банковских и продуктов нефинансовых компаний, обозначена сущность финтеха, определена его технологическая основа. Указывается, что внедрение финтеха в банковские структуры приводит, к принципиальному изменению IT-систем. Определены особенности конкуренции и взаимодействия банков, стартапов при реализации проектов, плюсы и минусы работы нефинансовых компаний и банков. Рассмотрен опыт цифровой трансформации Сбера, Tinkoff. Освящены вопросы работы микрофинансовых организаций. Рассмотрена опасность киберугроз финтеха на современном рынке и неудовлетворительная проработанность вопроса в правовом поле. Показаны перспективы дальнейшего развития цифровой трансформации финтех отрасли.
ПОДГОТОВКА СПЕЦИАЛИСТОВ, ВЛАДЕЮЩИХ ИНОСТРАННЫМИ ЯЗЫКАМИ, В ЭПОХУ ЦИФРОВИЗАЦИИ: ПРОБЛЕМЫ И ПЕРСПЕКТИВЫ
Authors: Мазур И. В.
Published: June 2022

Актуальность исследования вызвана реализацией национальной программы «Цифровая экономика Российской Федерации» во всех сферах общества, в том числе в сфере изучения и преподавания иностранных языков и культур в высшей школе. Сложившаяся в последние годы санитарно-эпидемиологическая ситуация во всём мире сделала использование цифровых технологий необходимостью во всех сферах нашей жизни. Целью настоящего исследования является определение и описание особенностей преподавания иностранных языков с учётом вызовов образования в современных условиях. Новые бизнес-модели цифровой экономики предполагают ориентацию преподавания иностранных языков с опорой на цифровые образовательные ресурсы. В статье рассматриваются особенности дистанционного обучения иностранному языку в эпоху цифровизации. Основной акцент сделан на организации учебного процесса с использованием бесплатных цифровых ресурсов. Определены преимущества и недостатки дистанционного обучения иностранным языкам с применением цифровых технологий.
ПРОБЛЕМЫ ОНЛАЙН ОБУЧЕНИЯ ИНОСТРАННОМУ ЯЗЫКУ: ИЗ ОПЫТА ПРЕПОДАВАНИЯ ЯПОНСКОГО ЯЗЫКА
Authors: Kondo Shizuno
Published: June 2022

This article reported on online tools for online classes and the advantages and problems of online classes using these tools. The purpose of this report is to help learners and teachers find the right tool for their teaching style and educational environment. This article reported on the strengths and weaknesses of two online meeting tools and seven other online tools that can be used inside and outside the classroom as tools to support online classes. In this article, online classes are defined as synchronous classes in which the teacher and several learners interact simultaneously through a screen by using the Internet to access a web communication tool that enables face-to-face communication.
ПОТЕНЦИАЛ ПОСЛОВИЦ И ПОГОВОРОК В ОБУЧЕНИИ ИНОСТРАННОМУ ЯЗЫКУ В НЕЯЗЫКОВОМ ВУЗЕ
Authors: Левченко В. А.
Published: June 2022

Пословицы и поговорки имеют значительный дидактический потенциал в обучении разным дисциплинам. В статье показаны различные способы организации работы с пословицами и поговорками на занятиях по иностранному языку в неязыковых вузах.
Carbon Monoxide Poisoning and Sequels of Cardiac Function
Authors: ÖZDEMİR Serdar , ALPER Barış , ALP Hamide , AKSEL Gökhan , DOĞANAY Fatih
Published: June 2022

Carbon monoxide binds to hemoglobin and shifts the oxyhemoglobin curve to the left, preventing oxygen from being released into the tissues. Thus, it can cause chemical anemia. Elevated levels of cardiac markers such as troponin may be seen when myocardial damage occurs. Electrocardiographic or echocardiographic changes can be monitored. To explain this damage in the myocardium, the toxic effect of carbon monoxide binding to myoglobin is also mentioned in addition to the oxidative stress of carboxyhemoglobin. Carbon monoxide-bound myoglobin is not capable of delivering sufficient oxygen to the myocardium.
EXPERIMENTAL ANALYSIS OF ULTRALIGHT AIRCRAFT TYRE BEHAVIOUR UNDER AIRCRAFT LANDING PHASE
Authors: Kubit Andrzej , Trzepieciński Tomasz , Święch Łukasz , Fejkiel Romuald
Published: June 2022

The aim of the research described in this paper is analysis of the deformation of the aircraft tyre subjected to static load. Based on the results of experimental tests with a different value of inflation pressure, favorable pressure conditions for use in the tyre of an ultralight aircraft were determined. The deflection characteristics of the tyre depending on the nominal pressure was determined using the digital image correlation technique. In the range of loads not leading to excessive tyre deflection, quite linear relation between vertical deflection and vertical force is observed. The safe minimum pressure in tyre loaded with a force of 12 kN is 2.5 bar. The experimental results will be used to select a shock absorber for a 600 kg ultralight, light sport aircraft commercialised by the company Ekolot (Krosno, Poland).
Current Approaches of the Czech Republic, the EU and NATO to Hybrid Threats
Authors: Havlík Martin
Published: June 2022

The article discusses the current approach of the Czech Republic to the phenomenon of hybrid threats and analyses the fundamental shortcomings that determine the effective management of these threats. As part of a comprehensive approach, the text is supplemented by the current view of the European Union and NATO on addressing the issue of hybrid action by hostile actors. A summary comparison of the approaches of the Czech Republic, the European Union and NATO points to the need for mutual institutional synergy among these entities. Although the current approaches of the mentioned subjects are relatively sufficiently doctrinally anchored, the absence of a complex and especially practically functioning apparatus and specific operational tools that would be able to face a wide range of hybrid threats persists.
Strategic Communications: From a Reactive Fight Against Disinformation Towards Comprehensive Use in Support of National Security and Defence
Authors: Divišová Vendula
Published: June 2022

The concept of strategic communications rose to prominence especially with the events linked to the Crimea annexation and Russian intervention in Eastern Ukraine. As such it has been mostly related to the reactive fight against disinformation and propaganda or other elements of the hybrid campaign. This paper aims to point to the much broader potential for the tool of strategic communications in support of goals in the realm of national security and defence, while it is understood as proactive efforts and specific mindset using the information effect to advance national interests. Based on the literature review, benefits of strategic communications beyond hybrid campaigns are identified also in the fields of foreign military operations, counterinsurgency, counter-terrorism, deterrence and crisis management. It describes the informational, particularly, the cognitive, dimensions of these security threats as well as of the measures to counter them.
Cognitive Hierarchy and Intelligence
Authors: Vojtek Jozef , Říha Josef , Šuhaj Miroslav
Published: June 2022

The article deals with the issue of the cognitive pyramid and the possible use of intelligence analysis in the context of gaining the understanding and wisdom of users of information using this pyramid. The cognitive pyramid is used to define the terms date, information, knowledge, understanding and wisdom that make up the various levels of the pyramid. The paper attempts to discuss concepts in different models of the pyramid. It briefly describes intelligence in the context of the use of intelligence by means of a cognitive pyramid. Intelligence is a special kind of knowledge. This article also seeks to explore how intelligence creation can be explained using a cognitive analytical pyramid model.
Description of a new Kurixalus species (Rhacophoridae, Anura) and a northwards range extension of the genus
Authors: Messenger Kevin R. , Othman Siti N. , Chuang Ming-Feng , Yang Yi , Borzée Amaël
Published: June 2022

Knowledge of biodiversity before species become extinct is paramount to conservation, especially when the relevant species are far from their expected distribution and, thus, likely overlooked. Here, we describe a new Kurixalus species corresponding to a range extension of Kurixalus on the Asian mainland, with the closest population in Taiwan. The species diverged from its closest relative during the Late Pliocene to Pleistocene, ca. 3.06 Mya (HPD 95%: 5.82-0.01), based on calibrations with a relaxed clock species tree of unlinked mtDNA 12S rRNA and nuclear DNA TYR. The status of the newly-described species is also supported by a divergence in call properties and morphometrics. We named the species described here as Kurixalus inexpectatus sp. nov. due to the nature of the discovery, as well as the adjunct distribution of the species relative to its closest congeners. The species was found in Zhejiang Province and it represents a range extension of 663 km for the Kurixalus genus.
Multiple Borel–Cantelli Lemma in dynamics and MultiLog Law for recurrence
Authors: Dolgopyat Dmitry , Fayad Bassam , Liu Sixu
Published: June 2022

A classical Borel–Cantelli Lemma gives conditions for deciding whether an infinite number of rare events will happen almost surely. In this article, we propose an extension of Borel–Cantelli Lemma to characterize the multiple occurrence of events on the same time scale. Our results imply multiple Logarithm Laws for recurrence and hitting times, as well as Poisson Limit Laws for systems which are exponentially mixing of all orders. The applications include geodesic flows on compact negatively curved manifolds, geodesic excursions on finite volume hyperbolic manifolds, Diophantine approximations and extreme value theory for dynamical systems.
Resources allocation optimization algorithm based on the comprehensive utility in edge computing applications
Authors: Liu Yanpei , Zhu Yunjing , Bin Yanru , Chen Ningning
Published: June 2022

In the mobile edge computing environment, aiming at the problems of few classifications of resource nodes and low resource utilization in the process of multi-user and multi-server resource allocation, a resource optimization algorithm based on comprehensive utility is proposed. First, the algorithm improves the Naive Bayes algorithm, obtains the conditional probabilities of job types based on the established Naive Bayes formula and calculates the posterior probabilities of different job types under specific conditions. Second, the classification method of resource service nodes is designed. According to the resource utilization rate of the CPU and I/O, the resource service nodes are divided into CPU main resources and I/O main resources. Finally, the resource allocation based on comprehensive utility is considered. According to three factors, resource location, task priority and network transmission cost, the matching computing resource nodes are allocated to the job, and the optimal solution of matching job and resource nodes is obtained by the weighted bipartite graph method. The experimental results show that, compared with similar resource optimization algorithms, this method can effectively classify job types and resource service nodes, reduce resource occupancy rate and improve resource utilization rate.
Novel Lagrange interpolation polynomials for dynamic access control in a healthcare cloud system
Authors: Chiang Te-Wei , Chiang Dai-Lun , Chen Tzer-Shyong , Lin Frank Yeong-Sung , Shen Victor R. L. , Wang Min-Chien
Published: June 2022

The authority of user personal health records (PHRs) is usually determined by the owner of a cloud computing system. When a PHR file is accessed, a dynamic access control algorithm must be used to authenticate the users. The proposed dynamic access control algorithm is based on a novel Lagrange interpolation polynomial with timestamps, mainly functioning to authenticate the users with key information. Moreover, the inclusion of timestamps allows user access within an approved time slot to enhance the security of the healthcare cloud system. According to the security analysis results, this healthcare cloud system can effectively resist common attacks, including external attacks, internal attacks, collaborative attacks and equation-based attacks. Furthermore, the overall computational complexity of establishing and updating the polynomials is O(n*m* (log m)2), which is a promising result, where m denotes the degree of $ polynomial~G\left(x, y\right) $ and n denotes the number of secure users in the hierarchy.
Mobilité et handicap : quelle perception du déplacement ?
Authors: Cadestin Charles , Dejoux Virginie , Armoogum Jimmy
Published: June 2022

ContexteAlors que la population âgée de 60 ans et plus constituera un tiers de la population française en 2060 (Blanpain et Chardon, 2010), la part de personnes qui rencontrent des situations de handicap risque d’augmenter ces prochaines années. En effet, avec l’âge, des déficiences tant motrices, visuelles que psychologiques peuvent apparaître et restreindre les activités et la mobilité.MéthodeIci, les différences de mobilité selon l’âge et la gêne ressentie au cours du déplacement sont analysées au moyen de l’Enquête nationale transports et déplacements (ENTD) de 2007-2008. La gêne dans les déplacements s’avère être un bon indicateur de la situation de handicap, reflétant principalement les difficultés liées à des déficiences physiques. Afin de pallier l’insuffisance des informations contenues dans les indicateurs, telles que le nombre de déplacement, la distance parcourue et la durée des déplacements, généralement utilisées dans l’étude de la mobilité par les déplacements, les données sur les motifs, le mode de déplacement ou encore l’heure de départ puis sur la perception que l’individu a au cours du déplacement sont ajoutées, permettant ainsi d’ouvrir la voie à une approche basée sur les activités.RésultatsLes personnes gênées lors des déplacements représentent environ 10 % de la population française, avec des degrés divers : tandis que la moitié d’entre elles peuvent se déplacer sur tout itinéraire, un quart d’entre elles ne peuvent pas se déplacer seules sans aide. Leur moyenne d’âge de 67 ans, contre 44 ans parmi les autres personnes de 15 ans et plus, atteste le lien étroit entre la gêne dans les déplacements et l’âge. Parmi les personnes de 75 ans et plus, c’est une personne sur deux qui se dit gênée lors des déplacements. Alors que les personnes non gênées réalisent 3,3 déplacements par jour, les personnes gênées n’en réalisent que 1,8 notamment à cause d’une forte immobilité parmi elles. Leurs horaires de déplacements sont davantage restreints, excluant les heures de forte affluence. À partir de 65 ans, avec l’âge et la gêne dans les déplacements, la marche et la voiture – en tant que passager – sont de plus en plus utilisées au détriment de la conduite et des transports en commun. Enfin les personnes gênées dans les déplacements font davantage attention à l’agrément du déplacement, à réaliser des activités ou éprouver des sensations au cours du déplacement.
International Student-Related Policies During COVID-19
Authors: Lin Yuqi , Zhang Chenyang
Published: June 2022

During the COVID-19 pandemic, international higher education underwent significant changes. To maintain the operation of international education and ensure the continuity of students' education, the Chinese and Australian governments have introduced a set of emergency policies. This study unpacks the policies that relate to Chinese students enrolled in Australian universities. It also summarises the unique modes built in these two contexts and critically identifies their similarities and distinctions. Based on these findings, it proposes the concept, co-creation, and highlights the trend in international education. It suggests that a virtual geographical space in international education has emerged during the COVID-19 pandemic, where the immobility of students is accepted. The establishment of the space requires collaborative efforts from governments, social organisations, and universities. Hence, the future of higher education is more about innovation than recovery.
Citizen Participation and Lawmaking at a Local Level in Massachusetts
Authors: Garcia Maria Jesus Garcia
Published: June 2022

In contrast to the extensive attention that has been paid to initiative and referendum lawmaking at state level, little attention has been paid to these mechanisms at local level. However, local government plays an important role when it comes to the making of decisions, the formulation of policies, and the delivery of public services across a wide range of areas. At this level, governmental action covers the particular needs of localities and local citizens. The proximity of local government to the electorate and to the needs and interests of citizens makes it clear that citizens must be given the opportunity to shape local policies and to take part in the decision-making process. Local government is the best scenario of trying out new ways of citizen participation. The closeness of local authorities to citizens makes it easier for citizens to become involved in policymaking. Decisions made at local level have a greater impact on citizens´ lives, so it seems like a logical consequence that they are empowered to participate in the decision-making process.
Public Libraries in the Post-COVID-19 Era
Authors: Al-Marzooqi Sara , Abdelaziz Hamdy Ahmed
Published: June 2022

The COVID-19 pandemic created a new reality for the educational sector in both formal and informal institutions. Educators in the UAE continued to offer classes and to communicate with their students virtually. Libraries, too, were able to continue to offer their educational services and provide free access to their digital environment for all ages around the public and private schools and universities. Technology has the potential to continue offering more advanced services to both universities and libraries. These services can be reimagined and introduced according to the new needs and demands after the pandemic and through business concepts. This paper explores the teachers’ and librarians’ perceptions on collaborating together within a common smart pedagogical approach, and the possibility it carries to improve the quality of their educational services. A case study was conducted in one of the library’s chain in the UAE to explore how smart technologies can promote productive collaboration between formal and informal education.
Ferroptosis resistance cooperates with cellular senescence in the overt stage of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis
Authors: Vetuschi Antonella , Cappariello Alfredo , Onori Paolo , Gaudio Eugenio , Latella Giovanni , Pompili Simona , Sferra Roberta
Published: June 2022

Cellular senescence and ferroptosis are the two main, fine-tuned processes in tissue damage restraint; however, they can be overactivated in pathologies such as nonalcoholic fatty liver disease/nonalcoholic steatohepatitis (NAFLD/NASH), becoming dangerous stimuli. Senescence is characterized by a decline in cell division and an abnormal release of reactive oxygen species (ROS), and ferroptosis is represented by iron deposition associated with an excessive accumulation of ROS. ROS and cellular stress pathways are also drivers of NAFLD/NASH development. The etiology of NAFLD/NASH lies in poor diets enriched in fat and sugar. This food regimen leads to liver steatosis, resulting in progressive degeneration of the organ, with a late onset of irreversible fibrosis and cirrhosis. Few studies have investigated the possible connection between senescence and ferroptosis in NAFLD/NASH progression, despite the two events sharing some molecular players. We hypothesized a possible link between senescence and ferroptosis in a NAFLD background. To thoroughly investigate this in the context of “Western-style” diet (WSD) abuse, we used an amylin-modified liver NASH mouse model. The main NASH hallmarks have been confirmed in this model, as well as an increase in apoptosis, and Ki67 and p53 expression in the liver. Senescent beta-galactosidase-positive cells were elevated, as well as the expression of the related secretory molecules Il-6 and MMP-1. Features of DNA damage and iron-overload were found in the livers of NASH mice. Gpx4 (glutathione peroxidase 4) expression, counteracting ferroptotic cell death, was increased. Notably, an increased number of senescent cells showing overexpression of gpx4 was also found. Our data seem to suggest that senescent cells acquire a gpx4-mediated mechanism of ferroptosis resistance and thus remain in the liver, fostering the deterioration of liver fitness.
MALAT1 regulates hypertrophy of cardiomyocytes by modulating the miR-181a/HMGB2 pathway
Authors: Chen Feng , Li Wenfeng , Zhang Dandan , Fu Youlin , Yuan Wenjin , Luo Gang , Liu Fuwei , Luo Jun
Published: June 2022

Noncoding RNAs are important for regulation of cardiac hypertrophy. The function of MALAT1 (a long noncoding mRNA), miR-181a, and HMGB2; their contribution to cardiac hypertrophy; and the regulatory relationship between them during this process remain unknown. In the present study, we treated primary cardiomyocytes with angiotensin II (Ang II) to mimic cardiac hypertrophy. MALAT1 expression was significantly downregulated in Ang II-treated cardiomyocytes compared with control cardiomyocytes. Ang II-induced cardiac hypertrophy was suppressed by overexpression of MALAT1 and promoted by genetic knockdown of MALAT1. A dual-luciferase reporter assay demonstrated that MALAT1 acted as a sponge for miR-181a and inhibited its expression during cardiac hypertrophy. Cardiac hypertrophy was suppressed by overexpression of a miR-181a inhibitor and enhanced by overexpression of a miR-181a mimic. HMGB2 was downregulated during cardiac hypertrophy and was identified as a target of miR-181a by bioinformatics analysis and a dual-luciferase reporter assay. miR-181a overexpression decreased the mRNA and protein levels of HMGB2. Rescue experiments indicated that MALAT1 overexpression reversed the effect of miR-181a on HMGB2 expression. In summary, the results of the present study show that MALAT1 acts as a sponge for miR-181a and thereby regulates expression of HMGB2 and development of cardiac hypertrophy. The novel MALAT1/miR-181a/HMGB2 axis might play a crucial role in cardiac hypertrophy and serve as a new therapeutic target.
Nuclear histochemistry: Its history in fifty volumes
Authors: Manfredi Romanini M.G.
Published: June 2022

The fiftieth anniversary of the double helix was marked two years ago. The elucidation of the structure of DNA by Watson and Crick can rightfully be considered to be "the" milestone in modern biology because it has conditioned the explosive growth in our understanding of the molecular mechanisms regulating the structural and functional organization of single cells and multicellular organisms....
Complete persistent remission of rheumatoid arthritis after COVID-19 infection - A rare case and literature review
Authors: Barman Bhupen , Nune Arvind , Ish Pranav , Phukan Pranjal , Lynser Donboklang , Sapkota Hem Raj
Published: June 2022

A 55-year-old man was admitted to a hospital in Northeast India with fever, cough and breathlessness and was diagnosed with severe COVID-19 pneumonia. He was a known case of seropositive, erosive rheumatoid arthritis (RA) and was taking disease-modifying anti-rheumatic drugs (DMARDs). The patient was treated with remdesivir, heparin and a short course of corticosteroids for COVID-19 pneumonia. With the improvement of COVID-19 pneumonia, the patient also noticed a marked improvement in his joint symptoms despite not taking any DMARDs for RA. The temporal relationship between the time of disappearance of all signs and symptoms of RA within a few days after COVID-19 pneumonia and maintenance of RA remission for over one year of follow up to date suggests that COVID-19 likely caused the remission of RA. This case highlights the need for larger studies to understand the COVID-19 effects on RA remission and their potential link if any. However, the evidence of worse outcome with COVID-19 in immunosuppression which is common in RA cannot be overlooked.
Efficacy of a rehabilitation protocol on pulmonary and respiratory muscle function and ultrasound evaluation of diaphragm and quadriceps femoris in patients with post-COVID-19 syndrome: a series of cases
Authors: Vieira da Costa Karina , Tainá Cordeiro de Souza Iara , Felix João Victor dos Santos , Brandão Celso Brendo Furtado , Fernandes Vanessa Michelle de Souza , Favero Andressa Bomfim Lugon , Gouveia Maria Lucrécia de Aquino , Lima Dyego Tavares de , Lima José Heriston de Morais , Pedrosa Rafaela , Onofre Tatiana , Brito Geraldo Eduardo Guedes de , De França Eduardo Eriko Tenorio
Published: June 2022

This study assessed the efficacy of a pulmonary rehabilitation (PR) on pulmonary and respiratory muscle function and thickness of quadriceps femoris and diaphragm of patients with post-COVID-19 syndrome. This series of cases followed nine patients who performed PR twice a week for six weeks. Patients received the following PR program: lung expansion therapy; respiratory muscle training; upper limb strength exercises; aerobic exercises on a treadmill. After the program, we observed increased peak expiratory flow (26.03%), forced vital capacity (FVC) (7.14%), forced expiratory volume in the first second (FEV1) (9.55%), and ratio between FEV1/FVC (6.19%). All parameters of respiratory muscle strength and endurance were improved. Diaphragmatic thickening fraction and thickness of quadriceps femoris also improved, whereas echo intensity of quadriceps reduced. Thus, RP protocol improved pulmonary function, respiratory muscle strength and endurance, and thickness of diaphragm and quadriceps femoris, and reduced echo intensity of quadriceps in patients with post-COVID-19 syndrome.
“Country Speech”: Regional and Temporal Linguistic Layering in Alice Munro’s Fiction
Authors: Gadpaille Michelle
Published: June 2022

Foregrounded reports of remembered speech habits typify Alice Munro’s short fiction. In one story, the author refers to this, almost casually, as “country speech.” I will examine instances of generalized speech tags (such as “As they used to say”) to explore their relation to the creation of spatial and temporal depth in the fictional landscape. Distinctions are established between types of these foregrounded speech tags, and the category of “country speech” is extended to include a related concept of “country manners.” These combine to help create the subtly layered distinctions between place (city, country, small town) and time (decades and generations) that add texture to Munro’s narratives.
Promoting faith-based tourism products in selected sacred spaces of south western Nigeria
Authors: Ezenagu Ngozi , Layefa Goodluck , Okpoko Patrick U , Okpoko Chinwe C
Published: June 2022

Travel for religious-related purposes – faith-based tourism is gradually becoming a renowned form of tourism globally. Experiencing this type of tourism has turned sacred spaces into tourist destination where visitors participate in different faith-based tourism products or activities. These are pilgrimages and dynamic ritual performances wherein the powers of spiritual entities are invoked and utilized by man. The efficacy of such activities in attracting huge tourist traffic is highly beneficial to sacred spaces economy. Despite, this positive impact, the consumption of faith-based tourism products are beset with challenges which militates its growth. To address the issue, this paper employed ethnographic research to investigate the challenging factors of
faith-based tourism products of three sacred spaces (Redemption Camp, Osun Osogbo Sacred grove and NASFAT camp) in southwestern Nigeria. There are numerous sacred spaces in the region of study, however; the selected spaces represent the three major religions (Christianity, Islam and African traditional religion) of the country. The study aims to address the challenges militating against the utilization of the uniqueness of faith-based tourism products in promoting sacred spaces as tourism destinations. The findings revealed that the major challenge that is posed is overcrowding but with improved infrastructure and sound instructions this can be adequately managed.
An analysis of online learning self-efficacy in the case of Vietnamese university students
Authors: Vy Luu Thi Mai , Thuyet Pham Thi Song
Published: June 2022

Given the recent emergence of online learning during the pandemic, attention has been given to self-efficacy, which refers to learners’ perceptions of their abilities to complete a specific task successfully (W. A. Zimmerman & Kulikowich, 2016). Self-efficacy is found to be predictive of learners’ achievement outcomes as well as their learning satisfaction, particularly in online settings in which learners are required to socially interact mainly via digital platforms. However, little research has been conducted to investigate the role of learners’ self-efficacy in the online learning environment in Vietnam. Therefore, this paper aims to explore the online self-efficacy of 544 Vietnamese undergraduates and its relationship with their gender and online prior experiences. The study adopted a validated questionnaire measuring online learning self-efficacy, highlighting five aspects: course completion, social interactions, online tool management, interactions with instructors, and academic socialization. The findings reveal an overall moderate belief of online self-efficacy from participants in all dimensions. Results regarding the associations between online self-efficacy with other variables are also discussed, and implications for online learning and teaching are provided.