bluuebunny/crossref_metadata_2025 huggingface dataset:
Connected Platforms for the Non-typical User: Design Methodology to Observe the Outliers
Authors:   Tecnologico de Monterrey, School of Architecture, Art and Design, Design Department, Del Puente #222, 14318, Mexico City, Mexico, Alvarez-Icaza Inés , Molina Arturo , Bustamante-Bello Rogelio
Published: November 2020

The Smart, Sensing and Sustainable Systems paradigm, known as the “S3 concept”, aims to promote the evolution of companies and academic environments through shared and adaptable knowledge. Therefore, this advancement follows new integrated products and services systems (PSS) designed to integrate everyone, everywhere, including non-typical users, i.e. people with disabilities, indigenous communities, elders, etc. By considering this it may facilitate Product and Service Systems design methodologies so to cover the articulate and non-articulate customer needs and in addition, using a social perspective. This research proposes a design framework to consider the non-typical human input analysis, along with the knowledge-sharing models exploration as academic collaboration platforms, to help Design and engineering students in identifying the best possible way of designing inclusive Sensible, Smart and Sustainable Systems, including a Social dimension.
Inclusive Dentistry: Integral Management of Pediatric Patients with Intellectual Disability and/or Communication Impairments. Case-Series Reports
Authors: Aguirre-González Gabriela , De Ávila-Rojas Paola , García-Flores Raúl , Ruiz-Rodríguez Socorro , Pozos-Guillén Amaury , Garrocho-Rangel Arturo
Published: November 2020

Dental treatment for anxious or fearful intellectually disabled children/adolescents (IDCA) may present great challenges, due to deficits in cognitive, intellectual, language, and social abilities, in conjunction with limited adaptive behavior. In many cases, it is necessary for the Dentist to implement advanced behavioral control techniques. Inclusive Dentistry (ID) considers profoundly each patient’s individual interests and likes, including the social and family situations, for choosing the respective personalized plan –contemplating potential risks and benefits– for the behavior control, in order to obtain the maximal possible cooperation of the patient in the dental chair. Through ID, the Pediatric Dental Practitioner aims to alleviate the anxiety and fear of IDCA in the clinical setting, in such a way that these patients are positively motivated, on a long-term basis, for current and future oral care, both at the dental office and at home. This management approach may be a time-consuming method or require more effort by the dentist, but it reaps benefits when applied for many mild-to-moderate (and some severe) IDCA. The Practitioner must possess the knowledge, in-depth understanding, and professional training for the adequate use of ID during the behavioral management of anxious or fearful IDCA. The aim of the present report was to describe four representative clinical cases of IDCA at our Clinic, managed under the philosophical principles of ID.
Assessment of New York Primary Care Physicians’ Knowledge, Attitudes, and Practices Related to Fluoride Varnish in an Urban Medical-Setting
Authors: Lian Lisa , Lumsden Christie , Yoon Richard , Sirota Dana
Published: November 2020

Objective: To determine changes in knowledge, attitudes, and practices of primary care physicians (PCPs) regarding fluoride varnish (FV). Study Design: Fifty-four PCPs at an urban medical center in New York completed a pre-intervention survey. A pediatric dental resident provided an hour-long educational lecture and a hands-on demonstration regarding FV application. Six months later, PCPs were sent a post-intervention survey via electronic mail. Results: Fifty-four PCPs participated in the pre-survey and FV training and 48% completed the post-survey. Prior to the FV training, 57% of PCPs knew that FV application by medical practitioners was reimbursable for children under 6-years-old and 2% of PCPs were applying FV. Post FV training, 62% of PCPs reported applying FV. Pre and post survey, barriers to FV application was not enough hands-on training (43% to 15% respectively) and not enough time (50% to 85% respectively). Conclusions: Post FV training, PCPs’ knowledge, attitudes and practices in regard to FV changed. Interprofessional education may be one approach to increasing FV application participation.
Conceções e práticas de avaliação da escrita: formação em São Tomé e Príncipe
Authors: Gorgulho Ana Rita , Costa Nilza , Santos Leonor
Published: November 2020

Neste artigo analisam-se conceções e práticas relatadas de 19 professores de Língua Portuguesa em São Tomé e Príncipe, como ponto de partida de uma oficina de formação. Numa abordagem qualitativa, privilegiou-se a análise de conteúdo dos dados de diversas fontes (questionário, reflexões em diário de bordo e registos da investigadora). Os principais resultados revelam que o ensino e a avaliação da produção escrita não estão totalmente ausentes das práticas destes professores, mas esta é ocasional e frequentemente não programada, resultando em constrangimentos. Crendo que lacunas de formação dos professores sobre avaliação têm influência nas conceções e práticas, defende-se que a formação contínua, partindo das necessidades dos professores, contribuirá para o seu desenvolvimento profissional.

Palavras-chave: Avaliação da Aprendizagem, Escrita, São Tomé e Príncipe, Avaliação Contínua.

 

Concepciones y prácticas de evaluación de redacción: formación en Santo Tomé y Príncipe

En este artículo, se analizan las concepciones y prácticas reportadas de 19 profesores de Portugués en Santo Tomé, como punto de partida para un taller de capacitación. En un enfoque cualitativo, el análisis del contenido de datos de diferentes fuentes (cuestionario, reflexiones en el cuaderno de anotaciones diarias y registros de la investigadora) fue privilegiado. Los principales resultados revelan que la enseñanza y la evaluación de la producción escrita no están completamente ausentes de las prácticas de estos profesores, pero son ocasionales y, a menudo, no están programadas, lo que genera limitaciones. Pensando que las lagunas en la formación del profesorado cuanto a la evaluación influyen en las concepciones y prácticas, se argumenta que la formación continuada, basada en las necesidades de los profesores, contribuirá a su desarrollo profesional.

Palabras clave: Evaluación del Aprendizaje, Redacción, Santo Tomé y Príncipe, Evaluación Continua.

 

Concepts and practices of writing assessment: training workshop in Sao Tome and Principe

In this article, the concepts and reported practices of 19 Portuguese Language teachers in Sao Tome and Principe are analyzed as a starting point for a training workshop. A qualitative approach favored the content analysis of data from different sources (questionnaire, reflections in the logbook and researcher records). The main results reveal that the teaching and assessment of writing are not totally absent from the practices of these teachers. However, they are occasional and often not planned, resulting in constraints. As we believe that gaps in teacher training on evaluation influence concepts and practices, we argue that ongoing training, based on teachers’ needs, will contribute to their professional development.

Keywords: Learning Assessment, Writing, Sao Tome and Principe, Continuous Evaluation.
Conhecimento das gestantes assistidas em uma unidade de atendimento obstétrico em relação à toxoplasmose gestacional
Authors: Acioli Steffany Costa , Porto Valnizete Bernardo Da Silva , Ferreira José  Rodrigo Da Silva , Maranhão Tereza Lúcia Gomes Quirino , Silva Sandra Regina Guimarães , Do Nascimento Cícera Maria Alencar , Rocha Thiago José Matos
Published: November 2020

Toxoplasmosis is a parasitic infection caused by the protozoan Toxoplasma gondii that has clinical importance in pregnant women due to the risk of congenital infections, which may cause serious consequences to the fetus. Many pregnant women do not take prenatal care or seek health care late, which can also make the control of toxoplasmosis difficult. In this work, we evaluated the knowledge of pregnant women assisted in an obstetric care unit regarding gestational toxoplasmosis. A cross-sectional study of a descriptive character was carried out with pregnant women attended at a Basic Health Unit in Maceió (AL). The research sample was the non-probabilistic for convenience, covering 20 pregnant women undergoing prenatal care. Data was collected through a standardized questionnaire, from August to October 2018. It was observed that the majority of pregnant women were aged between 18 and 23 years old (50%) and had completed elementary school (45%). With regards to the knowledge about toxoplasmosis, most of the pregnant women were unaware of this zoonosis (75%). Regarding the possible factors associated with the occurrence of infection by T. gondii, 85% of pregnant women reported eating well-cooked meat, 55% consuming filtered water, 45% consuming boiled milk and only 20% reported having cats at home.
Brookie: uma plataforma para suporte ao agronegócio de equinos
Authors: Herculano da Luz Júnior Silvano , Medeiros Juliana Dantas Ribeiro Viana de , Novo Amanda Days Ramos , Dantas Souza Heverton Luiz , Monteiro Silva Victor
Published: November 2020

This paper presents the results of an applied and exploratory research whose purpose was the design and development of a software called Brookie, for buying and selling horses, created to facilitate the negotiations between sellers and buyers of the equine market. The software is based on a web platform and was developed using the agile methodology called Scrum, it can also be accessed through mobile devices, in the future. The functionalities available in the software were identified based on the needs pointed out by people with horse market expertise, who identified relevant gaps in the solutions currently available on the web for the horse market. The article’s conclusion presents the positive and negative points about the development of the project
Práticas educativas contextualizadas e motivadoras: uma análise a partir das teorias de Hull, Hebb e Lewin
Authors: Abreu Tatiana Losano de , Epaminondas Débora Lins , Santos Júnior Cândido dos , Lira Andréa De Lucena , Chaves Alexandra Cristina
Published: November 2020

Several thinkers developed theories to understand the learning process and make it more effective. Clark Leonard Hull, Donald Olding Hebb, and Kurt Lewin are three theorists who, in different contexts, contributed to this debate. This paper aims to study the contribution of these authors to understand the role of contextualized and motivational educational practices in the learning process. Therefore, we developed exploratory research with qualitative/quantitative aspects. In addition to the theoretical study, we wrote a report of the experience on a technical visit to Engenho Triunfo - Areia (PB) with 22 postgrad students in Professional Education, accompanied by a team of five professors. They completed an online self-elaborated questionnaire about the topic of the research. Results indicated that Hebb’s study of neural networks of the learning and motivation curve proposed by Hull, and Lewin’s idea of living space, help us to theoretically understand the importance of contextualized and motivational education for the learning process. The analysis of the experience of the technical visit corroborated this idea, as participants attested to the contribution of this experience to learning through contextualization, the relationship between theory and practice and interdisciplinarity and motivation.
Automated method for calculating the Dst-index based on the wavelet model of geomagnetic field variations
Authors:   Institute of Cosmophysical Research and Radio-Wave Propagation of the Far Eastern Branch of the Russian Academy of Sciences (IKIR FEB RAS), Mandrikova O.V. , Stepanenko A.A. ,   Kamchatka State Technical University
Published: November 2020

A method for calculating the geomagnetic activity index Dst (Dst-index) based on a wavelet model of geomagnetic field variations is proposed. The method allows values of the Dst-index to be automatically obtained with a 1-minute resolution. The method is tested using data from equatorial stations [1]. The paper describes a calculation algorithm and presents estimation results. The calculation results are compared with the classical approach and the Kyoto method [2]. It is shown that the proposed method allows values of the Dst index to be obtained in the on-line mode with an admissible error.
Methods of mathematical modeling of fundus laser exposure for therapeutic effect evaluation
Authors:   Samara National Research University, Shirokanev A.S. ,   IPSI RAS – Branch of the FSRC “Crystallography and Photonics” RAS, Kibitkina A.S. ,   Samara National Research University,   IPSI RAS – Branch of the FSRC “Crystallography and Photonics” RAS, Ilyasova N.Y. ,   Samara National Research University,   IPSI RAS - Branch of the FSRC “Crystallography and Photonics” RAS, Degtyarev A.A. ,   Samara National Research University
Published: November 2020

When laser coagulation of eye retina is carried out, the laser beam is directed to target retinal areas selected by an ophthalmologist. The exposure to laser light produces a photocoagulate. When using laser coagulation, the main problem is selecting both the laser exposure areas that would cover all pathological zones and the laser exposure parameters to prevent retina damage. Any patient has an individual fundus structure. The individual structure of pathological and anatomical elements must be taken into account to achieve the desired therapeutic effect. The formation of coagulates in all hemorrhage-affected areas results in the desired therapeutic effect. The vascular layer must be heated to a sufficient temperature to form a coagulate. Such an effect can be predicted using mathematical modeling of laser exposure. In this paper, we consider methods of mathematical modeling of laser exposure based on the solution of a heat equation. The methods are compared in terms of their computational complexity and solution stability. An analysis of the possibility of predicting the therapeutic effect using methods of mathematical modeling of laser exposure is carried out.
Properties of off-axis caustics of autofocusing chirp beams
Authors:   IPSI RAS – Branch of the FSRC “Crystallography and Photonics” RAS, Ustinov A.V. , Khonina S.N. ,   IPSI RAS – Branch of the FSRC "Crystallography and Photonics" RAS; Samara National Research University,   Samara National Research University
Published: November 2020

Autofocusing properties of chirp beams with an arbitrary power-law dependence on the radius are studied theoretically and numerically. Two- and three-parameter chirp beams are considered, the parameter variations of which make it possible to effectively control their autofocusing properties. The results obtained have a potential for various applications in optics and photonics.
Trap magmatism influence on the gas zonality of the western part of the Leno-Tungus petroleum bearing province
Authors:   Federal State Budgetary Scientific Institution Trofimuk Institute of Petroleum Geology and Geophysics SB RAS, Gordeeva Alevtina O. , Novikov Dmitry A. ,   Federal State Budgetary Scientific Institution Trofimuk Institute of Petroleum Geology and Geophysics SB RAS; Novosibirsk State University, Chernykh Anatoly V. ,   Federal State Budgetary Scientific Institution Trofimuk Institute of Petroleum Geology and Geophysics SB RAS, Dultsev Fedor F. ,   Federal State Budgetary Scientific Institution Trofimuk Institute of Petroleum Geology and Geophysics SB RAS
Published: November 2020

The results of the analysis of trap magmatism influence on the geochemistry of gas (free and water-dissolved) and their zonality within the western regions of the Lena-Tunguska province are presented. Hydrocarbon gases in the free and water-dissolved phases were subjected to degradation processes during the time of trap eruption. In the contact zone (up to 100 m), carbon dioxide dominates in the composition of gases with a content of more than 90 vol.%, with a methane content of up to 5 vol.%. At a distance of 250 m, carbon dioxide concentrations decrease to 30 vol.%, and methane content grow to 60-70 vol.%.
Lithology and palynology of neogene-quaternary sediments of Sardakh island (the Lena river delta)
Authors:   A.A. Trofimuk Institute of Petroleum Geology and Geophysics, SB RAS, Kartoziia Andrei A. , Kuzmina Olga B. ,   A.A. Trofimuk Institute of Petroleum Geology and Geophysics SB RAS, Khazina Irina V. ,   JSC “Institute of geology and development of fossil fuels”, Russia, Moscow, Khazin Leonid B. ,   JSC “Institute of geology and development of fossil fuels”, Russia, Moscow, Mishina Anastassiya V. ,   V. S. Sobolev Institute of Geology and Mineralogy SB RAS
Published: November 2020

Results of the study of Neogene-Quaternary deposits of Sardakh Island (the Lena Delta) are described here. Taxonomic composition and spore-pollen spectra structure analysis indicated that sandstones, which are located in the section bottom have middle-late Miocene age. The middle part of the studied section has a Pliocene - early Pleistocene age. The upper part has a late Pleistocene age. We assume that sediments were deposited in the river environments.
Structural Model of Explaining Social Problem Solving Skills in Teachers Based on Organizational Culture and Religious Orientation: The Mediating Role of Intellectual Property
Authors: Al-Husseini Khadijeh Abolmaali , Mirghafoorian Fazeleh , Razian Sara
Published: November 2020

The aim of this study was to provide a structural model for explaining social problem solving skill in teachers based on organizational culture and religious orientation with the mediating role of intellectual property. The research method was of correlation type. The statistical population of the study was the teachers employed in the academic year 2017-2018 in two regions 1 and 6 of Tehran province. The statistical sample included 250 male and female teachers who were selected by the cluster random sampling method. For data collection, 4 questionnaires of social problem solving skill (De Zorilla et al., 2002), religious orientation (Bahrami, 2001), intellectual property questionnaire (Bonitz (1998), and organizational culture questionnaire with the Islamic approach of Attaran et al. (2017) were used. Data were collected using structural equation modeling (SEM) and analyzed at two levels of descriptive statistics and inferential level using AMOS and SPSS-22 software. The results showed that effective religious orientation predicts the adaptive skills of social problem solving in a positive and meaningful way and also intellectual property predicts adaptive skills of social problem solving in a positive and meaningful way in teachers. On the other hand, the findings indicated that intellectual property mediates the relationship between organizational culture and adaptive problem solving skills in a positive and meaningful way. But intellectual property does not significantly mediate the relationship between effective religious orientation and maladaptive social problem-solving skills. According to the research results, adaptive social problem solving skills of teachers are predicted based on organizational culture and religious orientation mediated by intellectual property.
The influence of melatonin on the parameters of cerebral hemodynamics in patients with hypertensive disease
Authors: Khoreva E. T. , Dem'yanenko Aleksey V. , Voronin T. S.
Published: November 2020

The authors discuss the results of application of melatonin in patients with hypertensive disease. Treatment with melatonin facilitated normalization of arterial pressure and cerebral hemodynamics at night time.
Strategy for the assessment of compliance with antiretroviral therapy in patients with HIV infection
Authors: Yushchuk N. D. , Fedyaeva Olga N. , Sirota N. A.
Published: November 2020

The study was aimed at identifying prognostic factors of antiretroviral therapy (ARVT) in patients with HIV infection at different stages of the disease and developing an algorithm for the three-component assessment of compliance with therapy. A total of 280 patients given ARVT for at least 6 months were available for comprehensive examination, questionnaire study for the detection of non-compliance risk factors, and psychological testing with the evaluation of non-compliance from the anxiety level (Sheehan scale) with the use of cluster analysis. The study revealed the most significant criteria for the assessment of compliance with therapy and non-compliance risk factors associated with ARVT conditions.
Microvascular angina. Modern aspects of pathogenesis, diagnostics and treatment
Authors: Yusupova Alfiya O. , Shendrygina A. A. , Privalova E. V. , Belenkov Yu. N.
Published: November 2020

Microvascular angina was included in the European guidelines on the management of patients with stable coronary artery disease in 2013. Topical aspects of etiology, pathogenesis, clinical course, diagnosis, and treatment of microvascular angina are discussed in this review.
Myocardial infarction caused by non-atherothrombotic lesion of carotid arteries
Authors: Popova Lyudmila V. , Khlevchuk T. V. , Axenova M. B.
Published: November 2020

Atherothrombosis is not the sole cause of myocardial infarction (MI). The clinical picture of MI of different origin is similar to the classical one. At the same time, coronaroangiography reveals changes in coronary arteries of patients with MI without atherosclerotic obstruction varying from totally intact vessels to atherosclerosis responsible for their 50% narrowing. MI without atherosclerotic obstruction is rarely encountered in clinical practice but regularly occurs in patients with acute coronary syndrome. Atherosclerotic obstruction was absent in 9-10% of the women and 7-8% of men with IM and ST segment elevation. Coronaroangiography demonstrated similar changes in women having MI without ST segment elevation. Men with the same condition exhibited atherosclerotic obstruction only in 4-7% of the cases. Unstable angina was associated with an enhanced frequency of unaffected coronary arteries which increased the difference between the two sexes. MI without atherosclerotic obstruction may be caused by a spasm of coronary arteries, eccentrically located plaques, Takotsubo syndrome, microvascular spasm, myocarditis caused by PVB19 virus, coronary embolism, thrombophilia, spontaneous dissection of coronary arteries, and their abnormalities. Patients having MI without atherosclerotic obstruction require evaluation of the risk of therapy on an individual basis.
Renal lesions associated with monoclonal gammopathies of undetermined significance: clinical forms, mechanisms of development, approaches to treatment
Authors: Kozlovskaya L. V. , Rameev V. V. , Kogarko I. N. , Gordovskaya N. B. , Chebotareva N. V. , Androsova T. V. , Roshchupkina S. V. , Mrykhin N. N. , Russkikh A. V. , Loshkareva O. A. , Sidorova E. I.
Published: November 2020

The term «monoclonal gammopathies of undetermined significance» (MGUS) was introduced by R. Kyle in 1978 to designate the condition characterized by the presence ofsmall amounts ofM-protein in the serum. In some patients, such condition remains benign for a long time but predetermines for the development of multiple myeloma and other B-lymphocytic tumours. Also, it can provoke non-cancerous diseases due to the toxic action of monoclonal proteins (immunoglobulins and free light chains) on various organs, especially kidneys. MGUS-associated renal lesions include glomerulopathies with organized deposits, such as AL-amyloidosis (amyloid light chain of immunoglobulin), cryoglobulinic and immunotactoid glomerulonephritis, and with unorganized deposits (light chain deposition and proliferative forms of idiopathic glomerulonephritis. The available experimental data throw light on the possible mechanisms of renal lesions. We summarized the literature data and original observations to describe methods for differential diagnostics of MGUS-associated renal lesions including the highly sensitive test for free light chine identification (Freelite method) and principles of pathogenetic treatment by the impact on the pathological B-cell clone.
The new combined parameter of hepatic and splenic elastography in patients with non-alcoholic fatty liver disease
Authors: Kassym Laura , Mysaev A. , Dazhani A. , Zhumadilova Z. K. , Nunu M. , Barkibaeva N. R. , Abukhammur A.
Published: November 2020

Objective of this study was is estimate the SSM/LSM ratio (SSM - splenic stiffness measurement, LSM - liver stiffness measurement) for patients with nonalcoholic fatty liver disease (NAFLD) who had evidence of fibrosis on elastography as determined by the ARFI technique with a view to searching for a possible relationship between the calculated readings, clinical, and laboratory parameters defining its impact on morbidity status. Materials and methods. Three hundred patients with NAFLD at different stages of fibrosis underwent liver stiffness and splenic stiffness measurements by ARFI. Results. SSM/LSM decreased from 5.02 (in F0 patients) to 1.11 (in F4) (p<0.001). The ratio showed moderate negative correlation with ALT (р=-0,324, p<0,001), AST (р=-0,373, p<0,001), APRI (AST/platelet count) (р=-0,431, p<0,001) and weak positive correlation with PLT count (р=0,274, p<0,001). In patients with fibrosis this ratio was higher in the presence of obesity (3,43±1,34) than in patients without it (2,61±1,21) (p=0,025). Conclusion. The numerical parameter SSM/LSM calculated from liver stiffness and splenic stiffness can be significantly reduced at advanced stages of fibrosis (1,34 (1,08;0,96;1,58) for F3 and 1,11 (0,81;0,69;1,33) for F4 providing a positive indicator of deteriorating liver disease in patients with NAFLD. In addition, the presence or absence of obesity as co-morbidity affects the degree of SSM/LSM reduction in patients with NAFLD.
The influence of adiponectin and leptin levels on myocardial remodeling in patients with type 2 diabetes mellitus and gout
Authors: Sharonova L. A. , Verbovoj A. F. , Canava Irina A. , Verbovaja N. I.
Published: November 2020

Background. There is a growing number of patients with type 2 diabetes mellitus. As a component of the metabolic syndrome, type 2 diabetes is often associated with hyperuricemia and gout. These diseases worsen prognosis of concomitant cardiovascular disorders. Purpose. To assess the relationship between adiponectin and leptin levels and echocardiographic parameters in patients with type 2 diabetes mellitus, gout, and a combination thereof. Materials and methods. The study involved 30 men aged 41 to 70 years divided into 3 groups. The first group included 10 patients with type 2 diabetes, the second one 10 patients with gout, and the third group consisted of 10 men with a combination of type 2 diabetes and gout. In all patients the levels of glucose, immunoreactive insulin, HOMA-IR, adiponectin, and leptin were measured. All patients underwent echocardiography. Results. The study revealed hyperglycemia in patients with type 2 diabetes and its combination with gout. Patients of all three groups had increased insulin resistance, insulin and leptin levels, deceased concentration of adiponectin. The thickness of interventricular septum in systole and diastole, posterior wall of the left ventricle in diastole, myocarduial mass of the left ventricle, the size of the left atrium and the right ventricle increased in patients of all three groups. Conclusion. The study demonstrated compensatory hyperinsulinemia and insulin resistance, hypoadiponectinemia, hyperleptinemia, left ventricular hypertrophy, diastolic dysfunction, and intact ventricular contractility in patients with type 2 diabetes, gout, and their combination. Hypoadiponectinemia and hyperleptinemia play a role in remodeling of myocardium in these patients.
Age-specific peculiarities of the clinical picture of acute cholecystitis
Authors: Balayan Gaik Z.
Published: November 2020

The problem of acute cholecystitis is now becoming ever more urgent bearing in mind a rise in morbidity and poor treatment results especially in elderly patients. Hence, the importance of studying age-specific peculiarities of clinical picture and evolution of this condition. The present study included 1273 patients with acute cholecystitis divided in 2 groups. It was shown that patients of advanced age more frequently suffer complicated cholecystitis. It is concluded that patients aged 60 years and more make up a high-risk group characterized by mildly manifest clinical symptoms and hospitalization at the late stages of the disease.
Dynamics of metabolic characteristics, markers of oxidative stress and vascular wall damage during treatment of obese prediabetic patients
Authors: Romanenko Irina A. , Polyatykina T. S. , Mavrycheva N. V. , Budnikova N. V. , Grinshtein V. B.
Published: November 2020

We studied lipid and carbohydrate metabolism, markers of oxidative stress (plasma malonic dialdehyde and dienoic conjugates) and vascular wall damage (CRP, microalbuminuria, blood desquamated endotheliocytes) before and after 12 week treatment of obese pre-diabetic patients. The study showed positive dynamics of the above metabolic parameters with normalization of carbohydrate metabolism in 60% of the patients and angioprotective effect ofprescribed therapy. The proposed treatment can be used to prevent diabetes mellitus.
Atherogenesis in human - clinical aspects of circulating immune complexes
Authors: Babintseva Yanina D. , Sergeeva A. M. , Karagodin V. P. , Orekhov A. N.
Published: November 2020

It has been suggested that circulating immune complexes containing low density lipoproteins (LDL-CIC) play a role in atherogenesis and are involved in the formation of early atherosclerotic lesions. The complexes, as well as anti-LDL antibody were found in the blood of patients with atherosclerotic process in various cardiovascular diseases, well as in the blood of animals with experimentally modulated atherosclerosis. One can assume that the presence anti-LDL antibodies in blood is a result of an immune response that is induced by modification of lipoproteins. LDL-CIC differ from native LDL in many aspects. They have much lower levels of sialic acid, a smaller diameter and a higher density electronegativity than native LDL. The fraction of the LDL-CIC in serum is an important manifestation of the atherosclerotic process. LDL-CIC, unlike the native LDL is able to induce intracellular accumulation of neutral lipids, especially esterified cholesterol in cell cultures obtained from healthy human aortic intima and macrophages in culture. After removal of the LDL-CIC, the serum of CHD-patients loses its atherogenic properties. The titer of the LDL-CIC in the blood serum significantly correlate with the progression of atherosclerosis and in vivo has the highest diagnostic yield of measured among other lipid parameters. Increasing CIC- cholesterol could also increase the risk of coronary artery atherosclerosis.
The possibilities and limits of modern bronchodilating therapy for COPD
Authors: Sinopal’nikov Alexander I. , Leshenko I. V. , Kostikas K.
Published: November 2020

This article is a critical review designed to assess the efficacy and safety of modern bronchodilating therapy for COPD patients.
Peculiarities of the psychic state and quality of life in patients with duodenal ulcer in the context of chronomedicine
Authors: Kolesnikov Dmitry B. , Rapoport S. I. , Voznesenskaya L. A. , Rasulov M. I.
Published: November 2020

Most clinicians consider duodenum ulcer as a psychosomatic disease. Objective: To show the interdependence of this condition and mental disorders and their relation to disturbances of melatonin production . Materials and Methods: 15 patients with seasonal DU and 15 healthy subjects of the control group were examined during 3 years using laboratory, endoscopic, and standard psychodiagnostic methods. Results. It was found that all patients with exacerbation of DU experienced enhanced anxiety, reduced background mood, and impaired quality of life based on general health and mental health scoring scales. The circadian rhythm of melatonin production was markedly distorted throughout the observation period but especially during exacerbations of the disease. Conclusions. The results indicate a high degree of correlation between DU and mental disorders caused by impaired production of melatonin. It suggests common etiological mechanisms of DU and psychosomatic symptom complex.
Hypothyroidism and cardiovascular system
Authors: Verbovoy A. F. , Sharonova Lyudmila A. , Kosareva O. V. , Verbovaya N. I. , Dolgikh Yu. A.
Published: November 2020

The article presents data on the relationship between thyroid dysfunction and cardiovascular diseases. The role of dyslipidemia, adipokines (adiponectin, leptin, resistin), C-reactive protein, deficiency of vitamin D3 in the development of cardiovascular disease in hypothyroidism is discussed. The article describes characteristics of myocardial remodeling, its dysfunction and their correlation with risk factors of cardiovascular diseases in patients with hypothyroidism.
Personified strategy for the correction of cardiometabolic risk factors in the alien population of the Arctic
Authors: Petrov Ivan M. , Sholomov I. F. , Petrova Yu. A. , Dorodneva E. F. , Medvedeva I. V.
Published: November 2020

Aim. To estimate the efficacy and prognostic value of individual consulting in Far North inhabitants during a 5 year survey. Materials and methods. 125 patients with metabolic syndrome were included in the study (24.8% women, 24.8% men, age median 45 years (39-48); p > 0.05). All the participants were divided into 2 groups dependence on the consulting frequency in the framework of the non-surgical body mass reduction programs (group 1 - single consulting, group 2 - repeated consultings in 12 months). Results. Individual consulting ofpatients with MS within 3 months after the onset of the study allowed the target body mass to be achieved in 50% of the patients in association with the reduction of atherogenic lipid fractions (p < 0,05), insulin resistance (p < 0,05), inflammation markers, hemostasis disorders markers (p < 0,05) and decrease in the number of patients with behavioral risk factors. Repeated educational module increased the relative probability 1,9 (95% CI 1,03-3,6) and odds ratio - 2.4 (95% CI 1,01-5,4) of body mass maintenance within 24 months and also reduced the risk of type 2 DM development (Cox's F-Test: F = 2,7; p = 0,041) and atherogenicity of lipid profile after 5 year observations. Conclusion. Our results proves the necessity of active utilization of educational modules at least as often as once a year. For the successful use of these modules based at outpatientfacilities of the Far North it is necessary to include a dietologist in the staff ofprophylactic departments which encounters difficulty under the modern funding mode.
Electrocardiographic aspects of morphogenesis of neuroleptic cardiopathy
Authors: Volkov Vladimir P.
Published: November 2020

Neuroleptic cardiomyopathy (NCMP) is a consequence of cardiotoxic side effect of antipsychotic drugs. Changes of ECG associated with this condition are poorly known. Aim. To elucidate dynamics of ECG at different clinical stages of NCMP and evaluate its diagnostic value.Methods. We determined the frequency and informative values of 8 different ECG signs includingQTinterval corrected based at theBazettformula (QTc). Their informative value was estimated from the Kullback formula. The data obtained were analyzed by parametric and non-parametric statistics methods. Results. Pathological changes of ECG parameters associated with NCMPreflect processes of structural rearrangement in the heart at different levels of its organization. The analysis of the available information showed that almost all ECG parameters have high diagnostic value listed in the following rank order (frequency/informativeness): rhythm disorder - 1/8, prolongation ofthe QTc interval - 4/3, conduction disorder - 2/2, diffuse muscular changes - 3/1, right heart overload - 5/6, left ventricular hypertrophy - 7-8/5, impaired electrical activity of myocardium - 7-8/5, deviation of the electrical axis to the left - 6/4. It seems appropriate to distinguish the following three maximally informative (and therefore most important) ECG signs indicative of developing NCMP: diffuse muscular changes, conduction disorder, and prolongation of theQTc interval. Conclusion. The analysis of the available information provides a new insight into dynamics of ECG signs associated with NCMP and permits to estimate the diagnostic value ofpathological changes for its earlier detection.
Physician’s anticredo from the standpoint of errologia medica: between theory and practice
Authors: Dimov Anatoliy S.
Published: November 2020

The author presents the clinical and methodological analysis of the problem of medical errors based on the empirical data obtained in the 20 century. Relevant theoretical premises having applied implications are substantiated.
Adherence to the treatment in patients with type 2 diabetes mellitus and ways to its optimization
Authors: Yarkova Natal’iya A. , Borovkov N. N.
Published: November 2020

A total of 148 patients (50 men and 98 women) with type 2 diabetes who weye hospitalized in the endocyinology depaytment «Nizhny Novgoyod Regional Hospital N.A. Semashko». It was shown based on the Moyisky-Gyeen scale that 91 patients (61.4%) did not comply with the doctoy's yecommendation. 57 (38.6%) patients adheyed to the tyeatment. The patients showing pooy compliance with the tyeatment weye divided yandomly into two gyoups. One was compyised of patients with type 2 diabetes (n = 45) who had been tyained in the school of diabetic patients, pyovided with a special liteyatuye and kept a diayy of self-monitoying blood glucose. The second gyoup consisted of patients with type 2 diabetes (n = 46) also tyained at the school of diabetes and pyovided with the yelevant liteyatuye but weye undey active contyol (telephone calls, visits to the centey). The yeay-long pyospective study demonstyated that adheyence to tyeatment incyeased in the entiye cohoyt. Howevey, statistically significant positive dynamics of clinical and biochemical payameteys was achieved only in the gyoup ofpatients actively monitoyed by medical peysonnel.
The risk of cardiovascular death in type 2 diabetes
Authors: Zeinalova N. V. , Kurbanov Yagub Ziyaddin , Mirzazade V. A. , Rzayeva R. A. , Novruzova M. S.
Published: November 2020

Aim. To evaluate effects of metabolic disorders on the risk of cardiovascular death in patients with type II diabetes based on Framingham risk score. We analyzed results of examination of 210 men and 210 women with type 2 diabetes who applied for medical care to the VM center of Endocrinology during 1997-2014. A virtual control group was formed matching real patients in terms of the number, sex, age, and height having ideal body mass index, total cholesterol and high-density lipoprotein cholesterol levels. The average risk of cardiovascular death in patients with type 2 diabetes was equal to 4,56±0,254% compared with 0,6±1,028% in the virtual control group. The differences was significant (p <0,001). The minimum risk for the patients of the two groups was estimated at 0,001% and 0,01% respectively. The maximum risk of cardiovascular death is 34,17% in patients with diabetes and 8,24% in controls. It is concluded that type 2 diabetes and related metabolic disorders significantly increase the risk of cardiovascular death.
Extragastric symptoms associated with Helicobacter pylori infection
Authors: Akhmedov Vadim A. , Gaus O. V.
Published: November 2020

This review article highlights the modern views of manifestations associated with Hp infection. The data are presented about the negative impact of the infection on the state of the musculoskeletal system, the development of migraine, progression of diffuse liver disease and the risk of developing liver cancer. The paper also provides information on the possible effects of Helicobacter pylori infection on the formation of halitosis, tympanosclerosis, male reproductive health disorders, colorectal cancer, Alzheimer's and Parkinson's disease, pre-eclampsia during pregnancy, and idiopathic chronic urticaria. In addition, the negative relationship between Hp infection, bronchial asthma, and inflammatory bowel disease is considered.
Dynamics of clinical, X-ray and functional data during treatment of patients with sarcoidosis
Authors: Vizel I. Yu. , Vizel Aleksandr A.
Published: November 2020

Aim. To analyze the literature data and the results of original studies on the respiratory function in patients with sarcoidosis. Material and methods. The study included 1199 patients with sarcoidosis (67.8% women and 32.2% of males, median age 43 years). The first X-ray stage was documented in 34.8% ofpatients , stage II in 57.0%, stage III in 6.1%, stage IV in 1.3%, stage 0 in 0.7%. One patient (0.1%) had pleural sarcoidosis. Loefgren syndrome was diagnosed in 20% of the patients. In 658 patients (54.9%) the diagnosis was confirmed by biopsy studies. Results. The patients with sarcoidosis exhibited significant correlation between radiographic and spirometric characteristics. In those with Loefgren syndrome, all breathing parameters were much better than in the remaining ones. Changes of spirometry parameters were more pronounced in smokers and in patients with concomitant lung diseases. However, the lung function remained impaired after adjustment for these factors, and 9,7% of the cases positively responded to the administration of a short-acting bronchodilator. Х-ray examination and spirometry are independent methods for the evaluation of the health status of patients with sarcoidosis and their results do not always correlate with each other after different treatment regimens. Changes in Х-ray image and lung vital capacity were consistent in patients treated with prednisone, methotrexate and pentoxifylline, but not in the cases treated with vitamin E and in the absence of treatment. Spirometry with simultaneous X-ray examination is recommended for all patients with intrathoracic sarcoidosis. Conclusion. Forced vital capacity of lungs (FVC) is an independent criterion for evaluating the condition of patients with sarcoidosis and the effectiveness of the treatment.
Melatonin in correction of the antioxidant status in patients with non-alcoholic steatohepatitis concomitant with type 2 diabetes mellitus
Authors: Popov S. S. , Pashkov A. N. , Bolotskih V. I. , Popova T. N. , Shulgin K. K. , Gorshkov I. P.
Published: November 2020

The purpose of the present work was the assessment of clinical efficiency of therapy including melatonin in patients with non-alcoholic steatohepatitis and concomitant type 2 diabetes mellitus. The study included 59 patients divided into two groups. The first group of 33 patients received basic treatment, the second group of 25 patients was given melatonin in addition to basic therapy. During the study the analysis of dynamics of clinical symptoms was carried out, the state of a free radical homeostasiswas evaluated by biochemiluminescense, and activity of enzymatic components of the antioxidant system (catalase and superoxide dismutase (SOD)) measured to compare effects of basic treatment and its combination with melatonin. Patients with non-alcoholic steatohepatitis showed the increase of gamma-glutamyl transpeptidase activity that reflected hepatic dysfunction, intensification of free radical oxidation processes, an imbalance the antioxidant system, namely decrease of the SOD activity and increase of the catalase activity. The combined treatment with melatonin produced more significant clinical effect in comparison with basic therapy as confirmed by changes in the clinical picture of the disease. At the same time, a greater decrease of the gamma-glutamyl transpeptidase activity, biochemiluminescent indicators, changes of SOD and catalase activities under effect of combined therapy with melatonin than in the patients given basic treatment was apparent. These findings can be attributed to melatonin antioxidant effect responsible for inhibition of free radical oxidation, reduction of the severity of imbalance in the function of antioxidant enzymes and suppression of the inflammatory process in the liver.
Benigne prostate hyperplasya and
adenocarcinoma: the role of signal molecules for diagnostics and therapy in patients of various age
Authors: Kvetnoy I. M.I. , Kheifec O. V. , Linkova Natal’ya S. , Konovalov S. S. , Kheifec V. Kh.
Published: November 2020

In the last years, new data on the role of microenvironment in involution of prostate cells (fibroblasts) and age-associated prostate oncogenesis have been obtained. The goal of this work is the investigation of expression of prostate fibroblasts, CXCL12, SDC1 proteins and hormones in normal and pathological prostate in subjects o different age. Materials were obtained from 78 patients with benignant prostate hyperplasia (BPH), 96 patients with prostate adenocarcinoma and 52 dead men without prostate pathology. All subjects were divided in 3 age groups (middle aged, elderly, and old) and investigated by electron, confocal and light microscopy and immunohistochemical methods. It was shown, that CXCL12 hyperexpression was characteristic of BPH and adenocarcinoma; this correlation became more pronounced with age. SDC1 expression in normal prostate decreased with age which may suggest age-related prostate involution. SDC1 expression in adenocarcinoma increased with. A slight decrease of chromogranin A and somatostatin expression was associated with normal prostate ageing. This process increased in BPH and prostate carcinoma. Chromogranin A and somatostatin decrease correlated with prostate ageing and oncopathology.
Combined chronic lympholeukosis
and Hodgkin lymphoma
Authors: Bakhtina Varvara I. , Demko I. V. , Kraposhina A. Yu. , Solov’eva I. A. , Sirotina T. A. , Gordeeva N. V.
Published: November 2020

Chronic lympholeukosis is the commonest form of leucosis in adults. Recent highly efficient methods of its treatment markedly increased life expectancy of the patients but simultaneously contributed to transformation of one tumour species into another. The article describes a case of Hodgkin lymphoma in a patient with the primary diagnosis chronic lympholeukosis.
Diagnosis and treatment of complicated Meckel’s diverticulum.
Authors: Timerbulatov V. M. , Timerbulatov M. V. , Mechdiev D. I. , Timerbulatov Shamil V. , Bikovski I. S. , Gabidullin I. R.
Published: November 2020

Meckel’s diverticulum (MD) is relatively rare, although frequent anomaly of the digestive tract, as a rule, in the event of complications or incidentally at laparotomy, laparoscopy, contrast study of the bowel. Aim - to examine the results of diagnosis and treatment of complicated forms of MD. Material and methods. It was a prospective non-randomized study of 77 patients with complicated forms of MD, including 30 adults and 47 children. The ratio of males and females in adult patients were 2,3:1, and 8,4:1 in children. The incidence of complicated forms in adults was 0,61 per 100,000 adult, 6,6 per 100,000 child population. The study was used clinical, laparotomy methods, ultrasound examination, CT, endoscopy, laparoscopy. Results. Diagnostic methods can identify complications (often diverticulitis, intestinal obstruction, peritonitis), and source-cause of complications is established by laparoscopy or laparotomy. Videolaparoscopic operations (diverticulectomy) made of 35%, the option of surgical intervention depended on the size of the diverticulum, the severity of degradation and prevalence of the inflammatory process in the wall ileum. Postoperative complications were 6,49% of patients, there were no cases mortality.