bluuebunny/crossref_metadata_2025 huggingface dataset:
Hepatocyte SGK1 activated by hepatic ischemia-reperfusion promotes the recurrence of liver metastasis via IL-6/STAT3
Authors: Li Xiangdong , Wang Ziyi , Jiao Chenyu , Zhang Yu , Xia Nan , Yu Wenjie , Chen Xuejiao , Wikana Likalamu Pascalia , Liu Yue , Sun Linfeng , Chen Minhao , Xiao Yuhao , Shi Yuhua , Han Sheng , Pu Liyong
Published: December 2022

Background
Liver metastasis is the leading cause of death in patients with colorectal cancer (CRC). Surgical resection of the liver metastases increases the incidence of long-term survival in patients with colorectal liver metastasis (CRLM). However, many patients experience CRLM recurrence after the initial liver resection. As an unavoidable pathophysiological process in liver surgery, liver ischemia-reperfusion (IR) injury increases the risk of tumor recurrence and metastasis.
Methods
Colorectal liver metastasis (CRLM) mouse models and mouse liver partial warm ischemia models were constructed. The levels of lipid peroxidation were detected in cells or tissues. Western Blot, qPCR, elisa, immunofluorescence, immunohistochemistry, scanning electron microscope, flow cytometry analysis were conducted to evaluate the changes of multiple signaling pathways during CRLM recurrence under liver ischemia-reperfusion (IR) background, including SGK1/IL-6/STAT3, neutrophil extracellular traps (NETs) formation, polymorphonuclear myeloid-derived suppressor cell (PMN-MDSC) infiltration.
Results
Hepatocyte serum/glucocorticoid regulated kinase 1 (SGK1) was activated in response to hepatic ischemia-reperfusion injury to pass hepatocyte STAT3 phosphorylation and serum amyloid A (SAA) hyperactivation signals in CRLM-IR mice, such regulation is dependent on SGK-activated IL-6 autocrine. Administration of the SGK1 inhibitor GSK-650394 further reduced ERK-related neutrophil extracellular traps (NETs) formation and polymorphonucler myeloid-derived suppressor cells (PMN-MDSC) infiltration compared with targeting hepatocyte SGK1 alone, thereby alleviating CRLM in the context of IR.
Conclusions
Our study demonstrates that hepatocyte and immune cell SGK1 synergistically promote postoperative CRLM recurrence in response to hepatic IR stress, and identifies SGK1 as a translational target that may improve postoperative CRLM recurrence.
Study protocol for a multicenter, multinational, observational registry of epidemiology, treatment and outcome of patients with Robin Sequence
Authors: Oechsle Anna-Lisa , Wiechers Cornelia , Abadie Veronique , Abel Francois , Breugem Corstiaan , Poets Christian F.
Published: December 2022

Background: Robin sequence (RS) is a congenital condition characterized by micrognathia, glossoptosis, and upper airway obstruction. Diagnosis and treatment are characterized by heterogeneity, resulting in a lack of uniformly collected data.
Methods: We have set up a prospective, observational, multicenter, multinational registry aimed at obtaining routine clinical data from RS patients receiving different treatment approaches and enabling an assessment of outcomes obtained through different therapeutic approaches. Patient enrollment has started in January 2022. Disease characteristics, adverse events, and complications depending on the different diagnostic and treatment approaches and their effects on neurocognition, growth, speech development, and hearing outcome are evaluated using routine clinical data. In addition to characterizing the patient population and comparing outcomes achieved with different treatment approaches, the registry will evolve to focus on endpoints such as quality of life and long-term developmental status.
Discussion: This registry will provide data on different treatment approaches collected during routine care with diverse framework conditions and will allow assessing diagnostic and therapeutic outcomes of children with RS. These data, urgently demanded by the scientific community, will increase the quality of the different therapeutic approaches and knowledge about the long-term outcome of children born with this rare condition.
Trial registration: DRKS00025365
A Note on Hilbert's ``Geometric'' Tenth Problem
Authors: Tyrrell Brian
Published: December 2022

This paper explores undecidability in theories of positive characteristic function fields in the “geometric” language of rings LF = {0, 1,+, ·, F}, with a unary predicate F for nonconstant elements. We indicate how to generalise existing machinery to prove the undecidability of the ∀1∃+-LF theory (without parameters) of any function field of a curve over an algebraic extension of Fp, not algebraically closed. We discuss the problem (and its geometric implications) further in this context too.
MSC Classification: 03B25 , 12L05
Incidence and risk factors for development of cardiac toxicity in adult patients with newly diagnosed acute myeloid leukemia
Authors: Boluda Blanca , Solana-Altabella Antonio , Cano Isabel , Martinez-Cuadron David , Acuña-Cruz Evelyn , Torres-Miñana Laura , Rodriguez-Veiga Rebeca , Navarro-Vicente Irene , Martínez-Campuzano David , García-Ruiz Raquel , Lloret Pilar , Asensi Pedro , Osa-Saez Ana , Aguero Jaume , Rodríguez-Serrano Maria , Buendía-Fuentes Francisco , Megías-Vericat Juan Eduardo , Martín-Herreros Beatriz , Barragan Eva , Sargas Claudia , Salas Maribel , Wooddell Margaret , Dharmani Charles , Sanz Miguel , Rubia Javier de la , Montesinos Pau
Published: December 2022

The incidence of cardiac morbi-mortality in acute myeloid leukemia (AML) is not well known. We aim to estimate the cumulative incidence (CI) of cardiac events in AML patients (pts) and to identify risk factors for their occurrence. Among 571 newly diagnosed AML pts, 26 (4.6%) developed fatal cardiac events and 19 (3.6%) among 525 treated pts (CI: 2% at 6 months; 6.7% at 9 years). Prior heart disease was associated with development of fatal cardiac events [Hazard Ratio (HR) = 1.9]. The CI of non-fatal cardiac events was 43.7% at 6 months and 56.9% at 9 years. Age ≥ 65 (HR = 2.2), relevant cardiac antecedents (HR = 1.4) and non-intensive chemotherapy (HR = 1.8) were associated with non-fatal cardiac events. The 9-years CI of grade 1–2 QTcF prolongation was 11.2%, grade 3 was 2.7%, and no patient had grade 4–5 event. The 9-years CI of grade 1–2 cardiac failure was 1.3%, grade 3–4 was 15%, and grade 5 2.1%; of grade 1–2 arrhythmia was 1.9%, grade 3–4 was 9.1%, and grade 5 1%. Among 285 intensive therapy pts, median overall survival decreased in those experiencing grade 3–4 cardiac events (p < 0.001). We observed a high incidence of cardiac toxicity associated with significant mortality in AML.
Breaking free from field layers: the interest of Post-Excavation Stratigraphies (PES) for producing reliable archaeological interpretations and increasing chronological resolution
Authors: Discamps Emmanuel , Thomas Marc , Dancette Christelle , Gravina Brad , Plutniak Sébastien , Royer Aurélien , Angelin Alexandre , Bachellerie François , Beauval Cédric , Bordes Jean-Guillaume , Deschamps Marianne , Ducasse Sylvain , Langlais Mathieu , Laroulandie Véronique , Mallye Jean-Baptiste , Michel Alexandre , Perrin Thomas , Rendu William
Published: December 2022

In order to track diachronic changes in archaeological sequences, researchers typically partition time into stratigraphic layers defined during fieldwork, which serve as the framework for ensuing analyses. These analytical units have a significant impact on archaeological inference, defining its resolution, and influencing both the study of cultural assemblages and the reconstruction of past environments. However, field layers are seldom re-evaluated after excavation despite the fact that archaeological deposits are now commonly recognised as often containing material ‘mixed’ together by site formation processes, excavation techniques or analytical practices. Although the analysis of intra-site spatial data clearly offers a means to overcome these issues, our literature review of 192 journal articles revealed the potential of this data (notably vertical projections of piece-plotted artefacts) to be under-exploited in Prehistoric archaeology. Here we advocate for the development of a more spatially-informed framework for interpretation that we refer to as Post-Excavation Stratigraphies or PES. After proposing a definition for “PES”, we attempt to develop a framework for theoretical considerations underlying their implication, importance, and potential. Three main benefits of PES are highlighted: ensuring assemblage reliability, increased chronological and spatial resolution, and more reliable interpretations based on a multi-stratigraphic approach. We contend that the stratigraphy defined during fieldwork is insufficient and potentially misleading. By providing a different “stratigraphic view” of the same sequence, each specialist can contribute data that, when combined, produces a better understanding of interactions between changes in, for example, technological or cultural traditions, subsistence strategies, or paleoenvironments.
Customer Benefits and Sharing Behaviour in Video Streaming Services: The Mediation Effect of Value Creation
Authors: Polat Volkan
Published: December 2022

Online video streaming services have become popular. This study aims to examine subscribers’ sharing behaviour on online digital video platforms. In almost all online channels, sharing behaviour has gained importance. Platforms may more simply and successfully reach their target audiences or consumers through sharing. On the other hand, customers may attend to value creation due to the benefits they gain from using goods and services. Marketers must comprehend how value creation is affected by customer benefits. This study is among the first studies examining the relationships between customer benefits, value creation, and sharing behaviour. Questionnaire-based research was employed to examine the foundation and framework-related hypotheses. Data was collected through the online survey forms. The data was obtained from 363 online streaming service paid users. The Structural Equation Model was performed using SPSS Amos 20 to test hypotheses. The statistical significance of the model’s estimations was tested using a single-step mediator model with a bootstrapping procedure. According to the findings, there was a significant relationship between customer benefits and instrumental value. However, there were very weak relationships between functional and psychosocial benefits and instrumental value. Financial benefit and instrumental value had a stronger relationship. Significant relationships were found between the variables customer benefits and terminal value. There was no significant relationship between instrumental value and sharing behaviour. As a result, there was no instrumental value-mediated relationship between customer benefits and sharing behaviour. The relationship between customer benefits and sharing behaviour, on the other hand, has been found to be mediated by terminal values. Functional and financial benefits and sharing behaviour did not directly and significantly relate. But this relationship became significant through terminal values (indirect-only mediation). Psychosocial benefits and sharing behaviour were directly and significantly related. It has been noted, nonetheless, that this relationship was strengthened by terminal value. The findings were assessed in light of the prior studies in the discussion section. In this section, some potential directions were suggested for future research.
Management and Leadership in the Klang Valley IT Sector: Conceptual Approach
Authors: Vasudevan Hemaloshinee
Published: December 2022

The aim is to conceptualize what makes for effective leadership in the Klang Valley IT sector. All industries need effective leadership; it ought to be brought up in the workplace. Employee motivation and performance could be improved through effective leadership. Additionally, employees are more committed to the organization, while lowers the turnover rate. Under successful leadership, an organization’s output and revenue can increase. The unethical behaviour by leaders who lack drive, confidence, foresight, and communication skills affects most industries. Perhaps these traits (ethics, motivation, trustworthiness, vision, and good communication) put things in perspective and provide direction as the author takes this challenging journey through a setting that only gets trickier as the person rises to the leadership level within the firm. This study will be able to improve leadership effectiveness through the issues’ goals. About 225 thousand people were working in the Malaysian IT sector. Each hypothesis has been observed and demonstrated. The substantial result was supported for each hypothesis from the previous study. In this instance, the conceptualized study has assessed and carried out fundamental analyses like descriptive, reliability, and validity analysis to determine how dependable the variables are for future research. The findings show that these dimensions (ethics, motivation, trust, vision, and good communication skills) are the essential elements of effective leadership. This study gave organizations and sectors reasons to raise employee levels of effective leadership to meet organizational goals and improve the attitudes and behaviours of leaders. Although there are many opportunities for exciting theoretical advancement and significant policy ramifications in this field of study, strict ethical guidelines must follow to have effective leadership quality in the IT sector. The novel aspect of this study is vision, which is a crucial element of the new leadership strategy. Followers and changes are prepared for their vision and are always necessary for this method.
Critical Delay Factors in Typical Physical Projects: The Case of the Ministry of Home Affairs in Malaysia
Authors:   Razak Faculty of Technology and Informatics, Universiti Teknologi Malaysia (UTM), Kuala Lumpur, MALAYSIA, Aminorlah Aishatul Izwani , Rahim Noorlizawati Abd ,   Razak Faculty of Technology and Informatics, Universiti Teknologi Malaysia (UTM), Kuala Lumpur, MALAYSIA, Mohamed Zainai ,   Razak Faculty of Technology and Informatics, Universiti Teknologi Malaysia (UTM), Kuala Lumpur, MALAYSIA, Mazlan Ain Naadia ,   School of Civil Engineering, Faculty of Engineering, Universiti Teknologi Malaysia (UTM), Johor, MALAYSIA
Published: December 2022

In Malaysia, public projects have been consistently reported as dilapidated and delayed, causing the government to bear financial losses. Furthermore, the purposes of the projects have not been fully achieved, thus affecting the public interest. This study examined the critical contributing factors to the delay in implementing physical projects in the Ministry of Home Affairs (MOHA). The scope involved the physical construction projects of the Immigration Department of Malaysia’s offices and premises in Malaysia, which was mandated in the 11th Malaysia Plan. A total of 105 respondents, including contractors, consultants, end-users and clients, participated in a survey on the factors and effects of physical project delay. The data were analysed using the relative importance index (RII) and Spearman’s correlation to identify the most critical delay factors and their association with delay effects. A total of 38 delay factors were identified, with contractor-related factors being the most critical, followed by consultant-related, client-related and other factors. These delay factors were found to be positively correlated with the effects of delay, including time and cost overrun, quality, litigation and arbitration, and abandonment.
Python Based User Interactive Voice Bot
Authors: Khare Akshay
Published: December 2022

In this paper, a python-based voice bot is proposed which is able to give answers to any question of the user and it should be able to follow commands of the user. AI is the main area of creating intelligent machines, particularly computer programs. It is related to the well-known task of employing computers to comprehend human intelligence. This paper provides an outline of the concept of a personal assistant for Windows-based platforms. The system is inspired by virtual assistants such as Siri for iOS and Cortana for Windows. It has been intended for performing a variety of operations by utilizing well-defined commands. This work focuses on assisting end-users with day-to-day activities such as searching questions on Google, general conversation with the user, searching for YouTube or other websites, automatic keyboard and mouse handling, sending mail, mathematical calculations, opening applications and files on the PC, clicking photos, and many more tasks. Machine learning is used to assess user statements/commands to provide the best solution.
Peer Tutoring on Enhancement of Mathematics Performance of Selected Grade 6 Students at Gregorio Herradura Elementary School, Victoria, Laguna, Philippines
Authors: Candelaria Philip Cyrill
Published: December 2022

Peer tutoring is a learning method that entails student partnerships that pair good students with lower achievers or pupils with comparable achievement for systematic reading and math study times. The main purpose of this study is to determine the problems of selected grade 6 students in mathematics that would help the students enhance their academic performance in the subject. The data gathering will be done by selecting grade 6 students, both female and male, with separate results from the conducted pretest and posttest questionnaires. Other students who do not fall into the category are not included in the collection of information. The only purpose of this study is to achieve its goal, and it won't investigate anything else. After using dependent T test at the scores of the students after pretest and posttest, we got a computed value (T Value) of -5.6803. With a critical value of -2.0195, we can reject the null hypothesis and conclude that peer tutoring can bring a significant difference to the combined result of critical thinking and problem-solving test. The finding suggests that school heads and classroom teachers may use "peer tutoring" as a learning method for helping the learners improve their performance in mathematics. The school and the classroom teachers may use peer tutoring as a learning method that entails student partnerships that pair good students with lower achievers or pupils with comparable achievement for systematic reading and math study times.
Analysis of somatometric parameters of children with recurrent subluxations of C1–C2 vertebrae
Authors: Fedorova E. P. , Kuzmin V. N. , Goncharova L. A. , Tanyushcheva N. Yu. , Kurkin A. M. , Alimusaeva M. R.
Published: December 2022

Introduction. The problem of instability in the cervical spine in children has been repeatedly discussed in the medical literature and has become the subject of discussion. This is due to a significant increase in the number and recurrence of subluxations in the C1–C2 segment. An assumption is made about the relationship of this pathology with systemic connective tissue dysplasia, but evidence-based studies are required.

Aim. To make a statistical analysis of individual somatometric indicators in children with recurrent subluxations of the C1–C2 vertebrae and signs of connective tissue dysplasia.

Materials and methods. The analysis of measurements of selected body parameters in pre-pubertal children with acute and recurrent torticollis against the background of systemic connective tissue dysplasia was carried out. The data of 186 children aged 9–11 years in comparative groups for the period 2016–2021 were studied. Modern methods of statistics were used.

Results. Dependences were obtained confirming the hypothesis of the relationship between asthenic physique (high height, low weight and chest circumference) and recurrent dislocations in the C1–C2 segment

Conclusions. When comparing the average values for two independent samples made up of the indicators of the main group and the comparison group, the conclusion obtained during visual examination and somatometric examination of patients diagnosed with torticollis at admission to the hospital was confirmed: relapses are inherent in children with high growth, low weight, smaller chest circumference and smaller wrist circumference.
Experience with the use of immunobiological drugs in the treatment of patients with severe bronchial asthma and comorbidities
Authors: Sereda V. P. , Svirido D. A. , Komarov M. V. , Smulskaya O. A.
Published: December 2022

Introduction. The accumulation of clinical experience in the use of biological therapy in patients with severe bronchial asthma (SBA) in real-world clinical practice with the possible identification of additional, previously undescribed clinical results is of practical interest.

Aim. The goal of the study is to present results of observational study that reflects experience of using benralizumab in SBA in real-world clinical practice in city of Saint Petersburg.

Materials and methods. We presents results of more than 1 year observation of 18 patients with eosinophilic SBA (12 females, 6 males, age from 28 to 74, average age 55 ± 11.9 years). Patients received benralizumab in addition to standard medical management. Conducted clinical, laboratory, functional examination of patients, assessment of the frequency of exacerbations and additional clinical effects.

Results. It was shown that the inclusion of benralizumab in complex therapy led to a significant improvement in disease control, improved bronchial conduction, a significant decrease in blood eosinophilia and a reduction in the number of exacerbations. Clinical examples are given that evidence to the stabilizing effect of this therapy on the course of recurrent nasal polyposis and the positive effects on the course of eosinophilic granulomatous polyangiitis, manifested by SBA.

Conclusions. In real clinical practice, the possibility of a significant improvement in control in patients with SBA with the use of biological therapy has been confirmed. At the same time, data have been obtained that will allow expanding the indications for the use of benralizumab in the future.
Genetic markers of the risk of fetal growth retardation in pregnant women with preeclampsia
Authors: Abramova M. Yu. , Ponomarenko I. V. , Orlova V. S. , Batlutskaya I. V. , Efremova O. A. , Sorokina I. N. , Churnosov M. I.
Published: December 2022

Introduction. Preeclampsia (PE) and fetal growth retardation (FGR), the main mechanism of which is the pathology of the placenta, directly affect the structure of both maternal and perinatal morbidity and mortality, which determines the medical and social significance of the study of PE and FGR, especially genetic predictors of the development of these complications of gestation. Objective. To study the involvement of GWAS polymorphism of significant arterial hypertension candidate genes in the formation of FGR in pregnant women with PE. Materials and methods. The samples for the study included 83 pregnant women with PE in combination with FGR and 369 women with isolated PE who were included in the control group. All women underwent a molecular genetic study of four polymorphisms: rs932764 PLCE1, rs167479 RGL3, rs633185 ARHGAP42, rs7302981 CERS5, and studied their relationship with the development of FGR in pregnant women with PE. The functional effects of polymorphic markers, which showed significant associations with the  formation of  FGR in  pregnant women with PE, were examined using international bioinformatic projects on functional genomics (HaploReg, GTExportal, PolyPhen-2). Results and discussion. The AA genotype of the rs9327643 locus of the PLCE1 gene significantly reduces the risk of FGR formation in pregnant women with PE according to the recessive model (OR = 0.37; p = 0.01; pperm = 0.01). The rs932764 polymorphic variant of the PLCE1 gene is located in the region of regulatory DNA motifs for 2 Hdx and Zic transcription factors, localized in the region of histone protein encoding H3K4me1 enhancers in the brain and associated with the expression of the HDAC1P1 gene in male gonad tissues. Conclusions. The polymorphic locus rs9327643 of the PLCE1 gene is associated with the risk of developing FGR in pregnant women with PE.
Modern biophysical view of electromagnetic processes of the phenomenon of life of living biological systems as a promising basis for the development of complex medicine: the role of water
Authors: Nevoit Ganna , Bumblyte Inga Arune , Potyazhenko Maksim , Minser Ozar
Published: December 2022

The results of a theoretical study of the role of water in electromagnetic generation and in the process of realizing the phenomenon of life are presented in the article. This article is a continuation of the theoretical study of the team of authors, which was published in the Journal of Complexity in Health Sciences, Vol. 5, Issue 1, 2022, p. 22-34. The aim of the theoretical study was to generalize the available scientific physical and biological knowledge of modern science about the role of water in the electromagnetic processes of the phenomenon of life at the cellular level in order to deepen the fundamental knowledge of Complex Medicine. This study is a fragment of research work on “Development of algorithms and technologies for implementing a Healthy Lifestyle in patients with Noncommunicable Diseases based on the study of functional status” (state registration number 0121U108237: UDC 613 616-056-06: 616.1/9-03). General scientific methods and theoretical methods were used in this theoretical study. The main conclusions of the theoretical study were made as follows: 1) Тhe “30/11 helix” is the main most typical fragmentary element of water self-organization into fractal structures and it forms energy-intensive fractal crystalline filamentous water structures in living biological systems, supported by energy constantly coming from biopolymers, and forming large constantly growing hierarchical structures that unite all the water of a living organism in a dynamic balance of opposite processes of destruction and growth of its energy-intensive crystalline structures; 2) Water has a key role in the process of transmission and perception of the coherent energy of a soliton through self-organizing fractal energy-intensive paramagnetic crystalline structures in living biological systems; 3) The phenomenon of biological life at the micro level is characterized by the presence of a state of water binding/organization into energy-intensive crystalline structures due to the constant supply of coherent energy from biopolymers and stops when this energy flow disappears, which corresponds to the onset of the phenomenon of biological death and is manifested by the degradation of energy-intensive fractal crystalline self-organization of water to an unbound water state. solution devoid of so-called biological anomalies.
Solitons in a cold electron beam plasma
Authors: Orinaite Ugne , Ragulskiene Jurate
Published: December 2022

Necessary and sufficient conditions for the existence of dissipative electron-acoustic solitons in a cold electron beam plasma with superthermal trapped electrons described by the Schamel equation are derived in this paper. Soliton solutions to the Schamel equation are constructed using formal analytical techniques which yield counter-intuitive conditions for the existence of these solutions. The existence conditions are derived in terms of system parameters and initial conditions. Computational experiments are used to validate the obtained results.
Drinking water distribution: corrosion control in Swedish municipalities
Authors: Berghult B. , Hedberg T. , Elfström Broo A.
Published: December 2022

Swedish action on corrosion control in drinking water distribution systems is evaluated. The extent to which chemicals are used and the costs of different processes are examined and the theoretical calculations of corrosion control effects are made. Improved measuring techniques and process evaluations are recommended with the objective of obtaining a more effective use of the chemicals. The content of copper and iron in water from different Swedish municipalities, before and after water treatment, was calculated using equilibrium models. The actions slightly decrease the iron corrosion in comparison with the drinking water without corrosion control, while the copper content in the water is somewhat increased.
Diversity of bacteria carrying antibiotic resistance genes in hospital raw sewage in Southeastern Brazil
Authors: Batista Marcos Paulo Barbosa , Cavalcante Fernanda Sampaio , Alves Cassini Sérvio Túlio , Pinto Schuenck Ricardo
Published: December 2022

In recent decades, antibiotic-resistant bacteria (ARB) emerged and spread among humans and animals worldwide. In this study, we evaluated the presence of ARB and antibiotic resistance genes (ARGs) in the raw sewage of two hospitals in Brazil. Sewage aliquots were inoculated in a selective medium with antibiotics. Bacterial identification was performed by MALDI-TOF and ARGs were assessed by polymerase chain reaction (PCR). A total of 208 strains from both hospitals were isolated (H1 = 117; H2 = 91). A wide variety of Enterobacterales and non-Enterobacterales species were isolated and most of them were Enterobacter spp. (13.0%), Proteus mirabilis (10.1%), and Klebsiella pneumoniae (9.6%). blaTEM and blaKPC were the most frequent β-lactamase-encoding genes and the predominant macrolide resistance genes were mph(A) and mel. Many species had the three tetracycline resistance genes (tetD, tetM, tetA) and strB was the prevalent aminoglycoside resistance gene. Two Staphylococcus haemolyticus strains had the mecA gene. Quinolone, colistin, and vancomycin resistance genes were not found. This study showed that hospital raw sewage is a great ARB and ARG disseminator. Strict monitoring of hospital sewage treatment is needed to avoid the spread of these genes among bacteria in the environment.
Preparation of two-component Pickering emulsion hydrogels for the removal of zinc ions from aqueous solutions
Authors: Gao Jing , Dong Chen , Zhao Yunting , Ma Tian , He Yongjun
Published: December 2022

Traditional liquid-solid extraction methods for the removal of zinc ions (Zn(II)) were generally limited by the leakage of extractant and low extraction capacity. The two-component Pickering emulsion hydrogels (PEHGs) in which the synergistic 2-ethylhexyl hydrogen-2-ethylhexylphosphate/tributyl phosphate (EHEHPA/TBP) was encapsulated in a semi-penetrating polymer network (SIPN) structured hydrogels polyacrylamide/sodium alginate (PAM/SA) were prepared by the Pickering emulsions polymerization route. The PEHGs were characterized by FTIR, SEM, TGA, and tensile mechanical measurements, and their self-healing properties were explored. The adsorption performance of PEHGs on Zn(II) was investigated. The results showed that the encapsulation of the extractant reached 95% due to the hydrogels network and nano-silica (nano-SiO2) particle network in PEHGs-15. The critical crashing pressure of PEHGs-15 was 0.084 MPa, and the adsorption after 3 h of healing was only 86% of the original amount. The maximum adsorption capacity of PEHGs-15 on Zn(II) was 76.51 mg/g at pH 5. The functional groups of SA and EHEHPA/TBP enhanced the adsorption capacity of PEHGs-15 by chelating with Zn(II). After five adsorption-desorption cycles, the adsorption capacity of PEHGs-15 exceeded 85% of the initial one. The excellent mechanical properties, self-healing, and regenerative properties of PEHGs-15 offer the potential to remove Zn(II) from the solution.
TEATRO PERFORMATIVO: DA CENA COM PESSOAS AFÁSICAS À CENA CONTEMPORÂNEA
Authors: CALLIGARIS JULIANA PABLOS
Published: December 2022

Este artigo reflete sobre o ato teatral performativo e a coocorrência de semioses verbais e não verbais em contextos de afasia. Meu enfoque recai na reconstituição de semioses multimodais pela afásica, não na ausência da afasia, mas na presença da afasia. A partir daí, investiguei a noção de densidade modal das semioses que se interconectam, visando salientar que elas são: distintas; que sua relevância na construção do sentido depende do recurso multimodal, da capacidade oral e motora da afásica, de recursos mais convocados e recorrentes na cena, do contexto de produção do sentido.
A PEDAGOGIA DO TEATRO EM TEMPOS DE PANDEMIA
Authors: Bezerra de Lima Erickaline
Published: December 2022

A partir das ideias conceituais da Pedagogia do Teatro, conduzimos reflexões acerca de como os professores de Artes, em especial os que ensinam Teatro, e outros professores que utilizam-se das práticas teatrais, desenvolveram suas propostas pedagógicas perante o desafio do trabalho remoto e outras limitações provocadas pela pandemia. Para tal, utilizamos como base da discussão 15 trabalhos apresentados no Grupo de conversa 3, no âmbito do II Colóquio Internacional Poéticas do Aprender: (im)possibilidades do teatro na escola em tempos de pandemia. Percebe-se que as variadas experiências que ocorreram no espaço-tempo da virtualidade alimentam o campo da pedagogia do Teatro, não podendo ser desconsideradas ou guardadas como práticas obsoletas presa no contexto. É preciso agregá-las e reconhecê-las como alternativa frente a um mundo tecnológico, para assim, serem requeridas sempre que necessário.
Sprawy incydentalne w procesie o stwierdzenie nieważnościmałżeństwa
Authors: Kiwior Wiesław
Published: December 2022

Przeprowadzone badanie dotyczące zagadnienia spraw incydentalnych w pro- cesie o stwierdzenie nieważności małżeństwa, uregulowane w Kodeksie Prawa Kanonicz- nego z 1983 roku oraz w instrukcji procesowej Dignitas connubii z 2005 roku, pokazuje, że jest to problematyka złożona i trudna. Odnosi się to do pojęcia sprawy incydentalnej (określenie ustawodawcy i doktryny); sposobu rozpatrywania i rozstrzygania kwestii incydentalnych, jakie pojawiają się w trakcie sprawy głównej; roli spraw incydentalnych w poszukiwaniu prawdy i w ochronie sprawiedliwości w konkretnej sprawie dotyczącej nieważności małżeństwa; sposobu podchodzenia do spraw incydentalnych ze strony sędziego i stron procesowych. Przepisy regulujące zagadnienie spraw incydentalnych w procesie o stwierdzenie nieważności małżeństwa zmierzają do tego, aby zapewnić szybkie rozpatrzenie i rozstrzygnięcie sprawy głównej, ograniczyć niewłaściwe opóźnie- nia procesu przez strony procesowe, zagwarantować stronom prawo do obrony. Słuszne wyważenie tych dwóch kierunków nie jest jednak łatwe.
Poważny brak rozeznania oceniającego (kan . 1095, n . 2 KPK) oraz niezdolność do podjęcia istotnych obowiązków małżeńskich z przyczyn natury psychicznej (kan . 1095, n . 3 KPK) . Wyrok Roty Rzymskiej c . McKay z 15 kwietnia 2013 roku
Authors: Kamiński Rafał
Published: December 2022

Komentowany wyrok, wydany w Rocie Rzymskiej jako trzeciej instan- cji, dotyczył dwóch tytułów: poważnego braku rozeznania oceniającego i nie- zdolności do podjęcia istotnych obowiązków małżeńskich z przyczyn natury psychicznej (kan. 1095, n. 2-3 KPK/83). Oba tytuły rozpatrywano po stronie powoda. W pierwszej instancji, głównie z braku wystarczającej opinii biegłego ex officio, wy- dano wyrok negatywny. Na stopniu apelacyjnym powołano kolejnych ekspertów, którzy zgodnie zdiagnozowali u mężczyzny zaburzenie narcystyczne. Dowód z opinii biegłych został poparty zeznaniami stron i świadków, co zaowocowało wyrokiem pozytywnym co do obu tytułów. Wnioski psychiatry powołanego na stopniu rotalnym wzmocniły tezę o istnieniu u pozwanego psychopatologii, która czyniła go niezdolnym, tak w obszarze rozeznania oceniającego, właściwego dla istotnych praw i obowiązków małżeńskich, jak i realizowania ich we wspólnocie z drugą osobą, jako mąż i ojciec potomstwa. Szczególnie cenną wiedzą, którą można uzyskać z lektury orzeczenia, jest sposób oceny dowodów, uzyskanych z opinii kilku biegłych, ich wzajemne odniesienie, a także ich umiejscowienie w całości materiału dowodowego.
Sócrates o el parásito de Derrida
Authors:   Universidad Alberto Hurtado, Castro Possi Florencia
Published: December 2022

Este trabajo apunta a realizar un análisis a partir de la lectura de Derrida del Fedro platónico en su ensayo La pharmacie de Platon. En tres apartados, Derrida trabaja los conceptos de phármakon, pharmakeus y pharmakós. No obstante, pareciera que el concepto de phármakon se presenta como un fenómeno jerárquico frente a los otros dos términos. La riqueza de este concepto radica en su ambigüedad e imposibilidad para ser traducido, ya que cuenta con una doble ‘naturaleza’: la de veneno y la de remedio. Nos interesa mostrar que, a pesar de la indecibilidad, polisemia e intraducibilidad del concepto de phármakon, existen razones para pensar al pharmakós, concepto que Platón no utiliza en su obra, pero que no por eso se encuentra ausente, como la otra cara del phármakon. El pharmakós es conocido como el ‘chivo expiatorio’, aquel sujeto que, como parte de un ritual de purificación comunitaria propio de la religión griega, se expulsa de la ciudad para extirpar los males que la aquejan. Se busca, entonces, rescatar la importancia del pharmakós, encarnada en la figura de Sócrates, entendida como una existencia parasitaria que, por medio del phármakon, se elimina de la ciudad.
Meslek yüksekokulu öğrencilerinin hijyen tutumları
Authors: Konu Kadirhanoğulları Meryem , Özay Köse Esra
Published: December 2022

Bu araştırma meslek yüksekokulu öğrencilerinin hijyen davranışına yönelik tutumlarının saptanması amacıyla yürütülmüştür. Araştırmada tarama yöntemi kullanılmıştır. Araştırma 2022 bahar döneminde bir devlet üniversitesine bağlı meslek yüksekokulunda okuyan 275 kız, 172 erkek olmak üzere toplam 447 öğrenci ile gerçekleştirilmiştir. Veriler Gül ve Özay Köse (2020) tarafından geliştirilen “Öğrenci Hijyen Ölçeği” ile elde edilmiştir. Verilerin analizinde non-parametrik testler kullanılmıştır. Araştırma sonucunda öğrencilerin toplam puan ortalamaları ile cinsiyetleri arasında istatistiksel açıdan anlamlı bir farklılık olduğu, ortalama puanları ile bölümleri arasında istatistiksel açıdan anlamlı bir fark olmadığı tespit edilmiştir. Araştırmada kız öğrencilerin hijyen davranışına yönelik tutum sıra ortalamalarının erkek öğrencilere göre daha yüksek olduğu belirlenmiştir. Öğrencilerin Hijyen ölçeğinde cevapladıkları maddeler cinsiyetlerine göre değerlendirildiğinde; Faktör 1 puanları ile cinsiyetleri arasında anlamlı bir fark olmadığı ancak kız öğrencilerin sıra ortalamalarının erkeklere göre daha yüksek olduğu belirlenmiştir. Öğrencilerin Faktör 2 puanları incelendiğinde ise anlamlı bir farkın olduğu belirlenmiştir. Ayrıca bölümlere bakıldığında sıra ortalaması en yüksek olan bölümün Sağlık Kurumları Yönetimi olduğu belirlenmiştir.
Ortaöğretim Kurumlarında Yürütülen Rehberlik ve Psikolojik Danışma Hizmetlerinin Çeşitli Değişkenler Açısından Öğrenci Gözüyle Değerlendirilmesi
Authors: Özay Köse Esra , Gül Şeyda
Published: December 2022

Bu çalışmanın amacı, liselerde yürütülen rehberlik ve psikolojik danışma hizmetlerinin genel durumunu öğrenci bakış açısıyla incelemektir. Çalışmada veri toplama aracı olarak daha önce farklı bir araştırmacı tarafından geliştirilen Okul Rehberlik Hizmetleri Ölçeği’ nden yararlanılmıştır. Türkiye’nin doğusunda bulunan bir il merkezinden uygun örnekleme yöntemi ile belirlenmiş ortaöğretim kurumlarındaki toplam 868 öğrenciden toplanan veriler SPSS 20.0 istatistik programında analiz edilmiştir. Elde edilen bulgular sonucunda ölçeğin geneline ait öğrenci görüşlerinin orta düzeyde olduğu belirlenmiştir. Bulgular alt boyutlara göre değerlendirildiğinde ise “psikolojik danışma hizmetleri”, “bilgi toplama ve yayma hizmetleri”, “yöneltme ve yerleştirme hizmetleri” ve “müşavirlik (konsültasyon) hizmetleri” boyutlarına orta düzeyde katılırken “oryantasyon hizmetleri”, “bireyi tanıma hizmetleri”, “izleme hizmetleri”, “çevre-veli ilişkileri hizmetleri” ve “araştırma ve değerlendirme hizmetleri” boyutlarına katılımlarının ise düşük düzeyde olduğu belirlenmiştir.
To investigate the role of rutin on bisphenol-A induced female infertility in rats
Authors: Yang Xiaoqi , Yang Tao , Wang Li , Cui Mengwan , Liu Cong , Wang Zhaorong , Cheng Xifeng
Published: December 2022

aims:

The proposed research work is designed to explore the role of rutin on bisphenol-A (BA) induced female infertility in the rat.

background:

Now a day, infertility is a major issue in the health care system. Currently, various chemicals and toxins are exposed to our biological system. Moreover, globally the improvement of reproductive health is alarming in developing and developed countries. The complete understanding and full therapeutic spectrum of natural medicines like citrus fruit-derived phytoconstituent i.e., rutin is not explored yet. However, rutin is contributed to the improvement of vascular health and smooth muscle tissue functions.

objective:

The proposed research work is designed to explore the role of rutin on bisphenol-A (BA) induced female infertility in the rat.

method:

BA is a potent endocrine disruptor and it causes female infertility in the rat. The inducer of oocyte maturation with nitric oxide donor i.e., sodium nitroprusside (SNP) was used for female infertility in the rat. The test compound rutin was administered with variable doses for 60 minutes per day for 21 days for this study.

result:

The female infertility of rats was assessed by male-female interaction behaviours, and anxiety behaviours were tested on 0, 7, 14, and 21st days. The biomarkers levels i.e., estradiol-17b (E2), follicle-stimulating hormone (FSH) and antimullerian tubulin hormone (AMH), reduced glutathione (GSH), and lipid peroxidation (MDA) levels were estimated at the end of the experimental protocol.

conclusion:

The treatment of rutin is ameliorated the BA-associated female reproductive behaviours and biomarkers level. Hence, it may be useful to improve female reproductive health due to its potential multi-targeted actions like hormonal regulation, anti-oxidant, and anti-peroxidative actions.

other:

N/A
Worriers of the Pandemic: How People with Mental Disorders
Cope with COVID-19 Restrictions
Authors: Zinchuk Mikhail , Pashnin Evgenii , Kustov Georgii , Popova Sofya , Voinova Nadezhda , Gersamia Anna , Yakovlev Alexander , Guekht Alla
Published: December 2022

Objective:

The aim of the study was to investigate the level of anxiety as well as the
attitude toward disease and mitigation strategies in people with non-psychotic mental disorders
and healthy controls.

Methods:

A case-control study (1:4) was conducted during a self-isolation regimen in Moscow.
Cases were adult patients with NPMD admitted to the Moscow Research and Clinical Center
for Neuropsychiatry. Sex and age-matched controls (individuals who have never sought psychiatric
help) were selected from a cohort of 7498 Moscow residents who participated in a
large cross-sectional survey delivered via social networks and popular Russian web platforms.
Fisher's exact test, Mann-Whitney U test, and General linear modelling were used as statistic
methods.

Results:

In the univariate analysis, patients with NPMD had a lower level of education and
were less likely to be married. The level of the trait but not state anxiety was higher in people
with NPMD. People with mental disorders were significantly more often concerned about the
negative impact of the COVID-19 pandemic on their lives, were more likely to be confident
that they would contract the coronavirus and their disease would be severe, showed suboptimal
adherence to mitigation strategies, were dissatisfied with the amount of information they received
about the COVID-19 disease, and were more concerned about becoming a victim of domestic
violence. Marital status, education, use of information resources, dissatisfaction with information
about COVID-19, use of public transport, paying attention to the need of others and
domestic violence assessment remained significant in the general linear model. All the factors
included in the multivariate model accounted for 36.4% of the variance.

Conclusion:

People with NPMD have a higher level of trait anxiety and are prompted to develop
a constellation of maladaptive beliefs toward a pandemic. These beliefs, along with the
lack of reliable information on coronavirus infection, can lead to misunderstanding and disregard
of sanitary and self-isolation recommendations. Educational programs and vaccination
campaigns should be sensitive to these features of people with NPMD.
REFORMASI BIROKRASI PERIZINAN BERUSAHA MELALUI ONLINE SINGLE SUBMISSION (OSS)
Authors: Pujiono Pujiono , Sulistianingsih Dewi , Sugiarto Laga
Published: December 2022

This paper aims to analyze the implementation of the Online Single Submission (OSS) with its advantages and disadvantages, as well as the obstacles in operating it. This study uses the socio legal method, where the legal aspect is related to the implementing OSS as a form of licensing transformation in the investment sector reduces investment processes and procedures in Indonesia, which have been considered convoluted, high-cost and do not guarantee legal certainty or the many institutions that have the authority to issue permits. Whereas the social aspect analyzes the advantages of the OSS system in displaying real time data from time to time related to business actor data, investor data that can be used as a basis for making a decision. The results shows that the constraints in the implementation of OSS are unstable internet networks in some parts of Indonesia and not all available human resources who operate the OSS system in the regions, which results in various policies made by local governments that contradict the OSS system.
POLITIK KRIMINAL PENANGGULANGAN TINDAK PIDANA KEKERASAN PSIKIS TERHADAP ANAK DALAM RUMAH TANGGA
Authors: Ibrahim Aji Lukman
Published: December 2022

This study aims to find the prime causes of psychological violence against children in the household and to formulate policies to overcome psychological violence against children in the household. This normative research uses a statute approach and a conceptual approach. The results of the study indicate that there are several prime causes of psychological violence in the household, such as the perpetrator’s lack of knowledge about the forms of domestic violence, the closure of children as victims, less harmonious relationships among family members, wrong way of parenting, psychological factors of the perpetrator, economic factors and the Covid-19 Pandemic. Overcoming psychological violence against children in the household can be done with a single-track system (penal) in the form of conditional sentence which is applied as shock therapy in order to prevent the perpetrator from repeating his actions. The double track system is in the form of action against the perpetrator, namely consultation with a psychologist. Meanwhile, non-penal efforts are in the form of pre-marital debriefing to the bride and groom about the forms of domestic violence, children’s rights and good parenting.
STATUS DARURAT KESEHATAN AKIBAT PANDEMI COVID-19 DALAM PERSPEKTIF HUKUM TATA NEGARA DARURAT DI INDONESIA
Authors: Hadi Fikri , Gandryani Farina
Published: December 2022

The COVID-19 pandemic which hit Indonesia has caused problems about the national emergency status that was announced on March, 31st 2020. Several local governments has requested to grant permission for doing own lockdown. The President also opened the option to declare the civil emergency for the worst-case scenario. This research analyzes the health emergency in the Indonesian legal system and the concept of lockdown and civil emergency that caused by such outbreak. This research is a doctrinal research using conceptual, legal and statutes approach. The result shows that the health emergency has been regulated on Law number 6 of 2018 on Health Quarantine. However, due to the vacuum of norm of its technical regulations in early pandemic, policies in order to handle COVID-19 was based on BNPB degree. The lockdown concept in Indonesian Law also had two means according to Health Quarantine Law namely Regional Quarantine and Large-scale Social Restrictions. Both are the authority of central government. Besides, it is concluded that The Civil Emergency is not appropriate if it is based on a disease outbreak such as COVID-19.