bluuebunny/crossref_metadata_2025 huggingface dataset:
Cycles of Beauty Culture: Ethnography of Beauty Clinics Commodification
Authors: Murlianti Sri
Published: September 2019

Skin care is not a completely new in beauty treatments. Previously there have been other types of cultural industry which also adopted the medical science, such as cosmetic and beauty salon industries. But, skin care beauty clinic successfully introduces the services of beauty treatments which are considered the healthiest. This paper is a summary of the research on how beauty clinic quickly became a part of everyday life of its consumers. The research focused on Natasha Skin Care, a most popular beauty clinic in Indonesia at the moment. According to Richard Johnson, the process of a culture industry reaches the society through a communication that in form a pattern cyclic communications. The stages in the pattern are interconnected but slipped, each stage is affecting others but are not specified in an uncertain manner; between the producer of culture industry with its consumers. This study is a multidiscipline research using three methods of interpretation namely ethnography, discourses analysis, and social hermeneutic study.Klinik kecantikan bukanlah budaya yang benar-benar baru dalam perawatan kecantikan. Sebelumnya telah ada jenis industri budaya lain yang juga mengadopsi ilmu kedokteran, seperti industri kosmetik dan salon kecantikan. Namun klinik kecantikan sukses menyandang predikat sebagai jasa perawatan kecantikan yang dianggap paling sehat. Tulisan ini merupakan rigkasan penelitian tentang bagaimana klinik kecantikan begitu cepat menjadi bagian hidup sehari–hari masyarakat konsumennya. Fokus penelitian ini adalah Natasha Skin Care, sebuah klinik kecantikan paling popular di Indonesia saat ini. Menurut Richard Johson proses sebuah industri budaya sampai pada masyarakat konsumennya melalui komunikasi yang timpang, membentuk pola komunikasi siklik, saling terhubung namun penuh dengan keterpelesetan, saling mewarnai namun tidak menentukan secara pasti antara produsen industri budaya dengan masyarakat konsumennya. Penelitian ini ditempuh dengan kerja multidispliner, menggunakan setidaknya tiga metode interpretasi, yaitu etnografi, analisis wacana dan hermenuitik sosial.
En memoria al Prof. Dr. Mario Julio Avila Campos
Authors: Ramos Perfecto Donald , Moromi Nakata Hilda
Published: October 2019

El Dr. Mario Julio Avila Campos, falleció el 28 de abril del 2019 en Sao Paulo, Brasil, hombre estudioso dedicado a conocer la microbiología anaerobia bucal, dejando múltiples investigaciones que sirvieron de base para otras, así como los conocimientos que nos permitió comprender mejor la fisiopatología de muchas bacterias periodontopatógenas. Su laboratorio de anaerobios del Instituto de Ciencias Biomédicas de la Universidad de Sao Paulo (ICB-USP) donde laboró hasta sus últimos días, pudo recibir a muchos estudiantes de pre y posgrado de diferentes nacionalidades, entre ellos peruanos que se formaron allí, teniendo apoyo para el desarrollo de sus proyectos de investigación.
Retos y propuestas de la profesión contable para el desarrollo de economías sustentables en Latinoamérica
Authors: María González José , Díaz Becerra Oscar Alfredo , Choy Zevallos Elsa Esther
Published: October 2019

Los reportes con información no financiera, especialmente de carácter ambiental y social, mediante la utilización de diversos estándares internacionales han generado en la profesión contable latinoamericana importantes desafíos, tanto respecto de su conocimiento como también en la implementación en las diversas organizaciones, especialmente en las pequeñas y medianas empresas, que constituyen factores necesarios para el desarrollo económico sustentable de la región. El proyecto de investigación se desarrolló mediante una encuesta estructurada para identificar las actividades empresariales que impactan en el medio ambiente latinoamericano, lo cual afecta el desarrollo económico sustentable, también se buscó relevar la responsabilidad social de las organizaciones, a través del análisis de sus Balances Sociales o Memorias de Sostenibilidad. Como marco de referencia teórico, para este tipo de reportes, se analizan conceptos de Contabilidad, su evolución y especialmente de la denominada Contabilidad Económica y de nuevas propuestas como el enfoque tridimensional de la Contabilidad. Uno de los estándares más utilizados en nuestra región latinoamericana son las Guías de Iniciativa de Reporte Global (GRI), pero con escaso uso por parte de las pequeñas y medianas empresas, por lo que será un interesante desafío intentar realizar una propuesta para que se considere en la preparación de las características de nuestras Pymes latinoamericanas y, de esta forma, lograr que los contadores públicos tengan la correspondiente formación académica.
Cladocera (Crustacea, Branchiopoda) of a temporary shallow pond from northern Colombia
Authors: Fuentes-Reinés Juan M. , Eslava-Eljaiek Pedro , Elmoor-Loureiro Lourdes M.A.
Published: October 2019

Eighteen species of cladocerans are recorded from a temporary pond in northern Colombia; 12 of these records are new for La Guajira Department: Diaphanosoma brevireme Sars, 1901, D. dentatum Herbst, 1968, Sarsilotona serricauda (Sars, 1901), Moina micrura micrura Kurz, 1874, M. reticulata Daday, 1905, Grimaldina freyi Neretina and Kotov, 2017, Kurzia polyspina Hudec, 2000, Leydigia cf. striata Birabén, 1939, Ovalona cf. glabra (Sars, 1905), Chydorus nitidulus (Sars, 1901), Dunhevedia crassa King, 1853 and Pseudosida sp.; this latter taxon could be an yet undescribed species. The cladoceran fauna from the surveyed area is represented mostly by widespread species and commonly found in the Neotropical regions, but local morphological data are scarce in the regional literature. Brief diagnostic descriptions of the species recorded for the Colombian cladoceran fauna are provided together with illustrations of taxonomically significant appendages, morphological remarks, notes on the variability of some species, and their distribution.
ADHD Diagnosis and Treatment Guidelines: A Historical Perspective
Authors: Wolraich Mark L. , Chan Eugenia , Froehlich Tanya , Lynch Rachel L. , Bax Ami , Redwine Susan T. , Ihyembe Demvihin , Hagan Joseph F.
Published: September 2019

Attention-deficit/hyperactivity disorder (ADHD) is the most common behavioral condition and the second most common chronic illness in children. The observance of specific behaviors in multiple settings have remained the most successful method for diagnosing the condition, and although there are differences in specific areas of the brain, and a high heritability estimate (∼76%), they are not diagnostically specific. Medications, and particularly stimulant medication, have undergone rigorous studies to document their efficacy dating back to the 1970s. Likewise, behavioral interventions in the form of parent training and classroom programs have demonstrated robust efficacy during the same time period. Both medication and behavioral interventions are symptomatic treatments. The availability of only symptomatic treatments places ADHD in the same category as other chronic conditions such as diabetes and asthma. Successful treatment of most individuals requires ongoing adherence to the therapy. Improved communication between patients and their families, primary and mental health providers, and school personnel is necessary for effective ADHD treatment. Further enhancement of electronic systems to facilitate family, school, and provider communication can improve monitoring of ADHD symptoms and functional performance. The American Academy of Pediatrics ADHD guidelines were initially developed to help primary care clinicians address the needs of their patients with ADHD and were further refined with the second revision in 2019.
The 2019 Joseph W. St. Geme, Jr Leadership Award Address: Ubuntu: The Power of Social Connections
Authors: Stapleton F. Bruder
Published: September 2019

The following is an address given by the author in receipt of the Joseph W. St. Geme, Jr Leadership Award, presented by the Federation of Pediatric Organizations at the Pediatric Academic Societies Meeting in Baltimore, Maryland, on April 27, 2019.
Determination of Urban Earthquake Risk for Kırşehir, Turkey
Authors: Isik Ercan , Sagir Coskun , Tozlu Zuhal , Salim Ustaoglu Umit
Published: October 2019

Predicting the outcomes of earthquakes before they occur is one of the fundamental components of modern disaster management. Loss estimation analyses have an important place at the assessment stage of earthquakes and in estimation of losses that earthquakes may lead to. With these analyses, it is possible to access information that is relevant to potential damages and losses. In this paper, loss estimation analyses were carried out by using the earthquake scenario which foresaw a previous earthquake that was experienced in an around Kırşehir which is seismically active and located in the Central Anatolia Region in Turkey. The 1938 Akpınar earthquake which occurred in and around the province of Kırşehir was taken into consideration as an earthquak escenario, and loss estimation analyses were conducted for this earthquake scenario. In this paper, significant contributions will be made for preparation of an earthquake master plan and risk management plan for Kırşehir. Besides, studies on reduction of earthquake losses in the region may utilise these results.
Evolución distinta de linfedema primario etapa II de miembros inferiores
Authors: López-Montoya Luis Enrique , Pereira-de Godoy José María , Guerreiro-Godoy María De Fátima
Published: September 2019

Introducción. Un linfedema es el aumento de fluido rico en proteínas y macromoléculas en el espacio intersticial de un segmento corporal con incremento de volumen en el miembro afectado, el cual causa cambios fibroescleróticos progresivos en los tejidos.Objetivo. Informar sobre la evolución clínica y el análisis de la progresión de un paciente de 52 años con linfedema bilateral primario estadio II.Presentación del caso. Paciente masculino de 52 años quien había sufrido por más de 20 años edema linfostático; el sujeto había recibido diversas opiniones y tratamientos inefectivos los últimos 5 años, hasta que llegó a la Clínica Godoy en Sao Jose de Rio Preto, Brasil, en el año 2016, en donde fue sometido a proceso de terapia intensiva según el modelo de tratamiento propuesto por Godoy & Godoy.Conclusión. Se obtuvieron resultados favorables en un periodo muy corto de tiempo; durante el proceso se observaron distintas evoluciones clínicas en cada pierna, aun recibiendo ambas el mismo tratamiento.
Bevacizumab as a treatment option in gastrointestinal bleeding associated to hereditary hemorrhagic telangiectasia. Case Report
Authors: Castillo Erwing , Prada-Arismendy Jeanette
Published: September 2019

Introduction: Hereditary Hemorrhagic Telangiectasia (HHT) is an autosomal dominant genetic disease characterized by the presence of arteriovenous malformations in the nasal mucosa, the tips of fingers, and sometimes in the lungs, the gastrointestinal tract, the liver, the pancreas, the marrow and the brain. Its treatment is based on symptomatic control measures, but recently, the administration of anti-vascular endothelial growth factor (VEGF) molecules has been proposed as a treatment alternative, especially in patients with recurrent bleeding.Case presentation: The case of a 67-year-old man diagnosed with HHT and suffering from potentially life-threatening gastrointestinal GI bleeding is presented. The patient underwent several esophagogastric cauterization procedures but not positive outcomes were obtained, so he had to go to the Emergency Service of the hospital multiple times due to having low levels of hemoglobin (as low as 3.5g/dl). A bevacizumab based treatment was started by using a novel dosage regimen consisting of the administration of 6 5mg/kg bevacizumab dosages every 14 days. During the first week of treatment, hemoglobin levels increased to 14g/dl and the condition was stabilized.Conclusions: The findings reported here suggest that bevacizumab may be a therapeutic choice to be considered when treating patients with recurrent and refractory GI bleeding caused by HHT. However, a larger sample is required to determine if administering this medication is safe for these patients, as well as the appropriate dosage.
Hipocratismo digital: conociendo sus causas. Reporte de caso
Authors: Uribe-Valencia Mauricio Andrés , Ocampo Chaparro José Mauricio , Parra-Camarillo Maximiliano
Published: September 2019

Introducción. El hipocratismo digital es un signo clínico que afecta principalmente los dedos de las manos y se caracteriza por deformidad en uñas con abombamiento en vidrio de reloj. Puede presentarse en pacientes con cáncer diseminado, enfermedad pulmonar preexistente y dolor óseo, por lo cual es importante considerar esta entidad para un diagnóstico y un tratamiento oportunos.Presentación del caso. Paciente masculino de 86 años con hipocratismo digital, tabaquista en abstinencia, quien ingresa a urgencias por cuadro clínico de 2 meses de evolución consistente en fiebre y pérdida de 19kg de peso. Al examen físico presentaba disminución de ruidos respiratorios en base pulmonar derecha, dedos en palillo de tambor y deformidad ungüeal en manos. La radiografía de tórax mostró opacidad a nivel parahiliar derecho bien definida de 5cm. La tomografía computarizada de tórax mostró masas de bordes irregulares a nivel parahiliar derecho y en segmento apical del lóbulo inferior del pulmón derecho, y derrame pleural ipsilateral. La biopsia guiada por tomografía documentó adenocarcinoma pulmonar bien diferenciado.Conclusiones. El hipocratismo digital plantea un desafío en medicina debido a que puede ser difícil llegar a un diagnóstico etiológico y se pueden requerir muchos estudios para su confirmación.
Tay-Sachs disease
Authors: Gualdrón-Frías Carlos Andrés , Calderón-Nossa Laura Tatiana
Published: September 2019

Introduction: Lysosomal storage disease is caused by the deficiency of a single hydrolase (lysosomal enzymes). GM2 gangliosidoses are autosomal recessive disorders caused by deficiency of β-hexosaminidase and Tay-Sachs disease (TSD) is one of its three forms.Objective: To perform a review of the state of the art on TSD describing its definition, epidemiology, etiology, physiopathology, clinical manifestations and news in diagnosis and treatment.Materials and methods: A literature search was carried out in PubMed using the MeSH terms “Tay-Sachs Disease”.Results: 1 233 results were retrieved in total, of which 53 articles were selected. TSD is caused by the deficiency of the lysosomal enzyme β-hexosaminidase A (HexA), and is characterized by neurodevelopmental regression, hypotonia, hyperacusis and cherry-red spots in the macula. Research on molecular pathogenesis and the development of possible treatments has been limited, consequently there is no treatment established to date.Conclusion: TSD is an autosomal recessive neurodegenerative disorder. Death usually occurs before the age of five. More research and studies on this type of gangliosidosis are needed in order to find an adequate treatment.
Role of Coxiella burnetii in the development of fever of unknown origin: А mini review
Authors: Genova-Kalou P. , Ivanova S. , Pavlova A. , Simeonov K. , Pencheva D. , Yotovska K.
Published: September 2019

Q fever is a widespread zoonosis throughout the world in the form of numerous natural and agricul-tural outbreaks. C. burnetii infects various hosts, including humans, ruminants and pets and in rare cases, reptiles, birds, and ticks. This bacterium is excreted in urine, milk, faeces, and birth products. In humans Q fever occurs as acute or chronic disease with diverse clinical presentation, as isolated cases and epidemics. It affects various organs and systems, and in pregnant women can cause miscar-riage or premature birth. Untreated Q fever can become chronic with adverse effects on patients. Diversity in the clinical picture in the absence of specific pathological syndrome often hinders accurate diagnosis and proper etiological significance. Therefore, improvement of diagnostic methods and in particular the development and introduction of new molecular diagnostic methods is the basis of effective therapeutic and prophylactic approach. Тhe purpose of the review is to renew the interest to Q fever – on one hand, because of its serious impact on human health and agricultural systems, and on the other, the ability for development and introduction of new molecular diagnostic methods.
Glioblastoma invasion and NMDA receptors: A novel prospect
Authors: Nandakumar DN , Ramaswamy P , Prasad C , Srinivas D , Goswami K
Published: September 2019

Purpose

Glioblastoma cells create glutamate-rich tumor microenvironment, which initiates activation of ion channels and modulates downstream intracellular signaling. N-methyl-D-aspartate receptors (NMDARs; a type of glutamate receptors) have a high affinity for glutamate. The role of NMDAR activation on invasion of glioblastoma cells and the crosstalk with α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) is yet to be explored.

Main methods

LN18, U251MG, and patient-derived glioblastoma cells were stimulated with NMDA to activate NMDAR glutamate receptors. The role of NMDAR activation on invasion and migration and its crosstalk with AMPAR were evaluated. Invasion and migration of glioblastoma cells were investigated by in vitro trans-well Matrigel invasion and trans-well migration assays, respectively. Expression of NMDARs and AMPARs at transcript level was evaluated by quantitative real-time polymerase chain reaction.

Results

We determined that NMDA stimulation leads to enhanced invasion in LN18, U251MG, and patient-derived glioblastoma cells, whereas inhibition of NMDAR using MK-801, a non-competitive antagonist of the NMDAR, significantly decreased the invasive capacity. Concordant with these findings, migration was significantly augmented by NMDAR in both cell lines. Furthermore, NMDA stimulation upregulated the expression of GluN2 and GluA1 subunits at the transcript level.

Conclusions

This study demonstrated the previously unexplored role of NMDAR in invasion of glioblastoma cells. Furthermore, the expression of the GluN2 subunit of NMDAR and the differential overexpression of the GluA1 subunit of AMPAR in both cell lines provide a plausible rationale of crosstalk between these calcium-permeable subunits in the glutamate-rich microenvironment of glioblastoma.
Unambiguous determination of point coordinates in the geodetic measurement network when establishing land records
Authors: Śmigielski Mateusz , Pijanowski Jacek , Gniadek Jacek
Published: September 2019

The article discusses the problem of unambiguous determination of the geodetic control net-
work points’ coordinates in the State Geodetic Coordinate System 2000, fixed during works
related to the establishment of land records. The solutions and measurement methods applied
in this respect, in accordance with the applicable standards, in many cases do not allow the cor-
rect identification of the boundary points of land plots in the process of their designation. The
data provided by the district centres of surveying and cartographic documentation (PODGiK)
concerning the point coordinates of measurement networks established for the purpose of cre-
ating land records in the period following World War II present a lot of problems for geodetic
contractors. Due to the lack of unambiguous coordinates of the geodetic network points, under-
taking additional work is often required, including the identification of geodetic network points
and verifying the compliance of their position in the field, based on the archival data. These are
time-consuming activities, and they do not always bring the intended effect. The present article
contains the results of the research on the compliance of archival data with the actual location of
points in geodetic networks, in several selected precincts of the Świętokrzyskie region. On the
basis of the analyses we have carried out, discrepancies were determined within the data con-
stituting the PODGiK resources, and a solution was proposed to obtain coordinates of geodetic
network points that could be considered correct.
The scope of examination of the real estate appraisal report in court of law and in administrative proceedings — selected problems illustrated with the jurisprudence of the supreme court, courts of general jurisdiction, and administrative courts
Authors: Zbylut-Górska Maria , Górski Adam
Published: September 2019

The article presents considerations regarding the practical problem of the scope of the examina-
tion or verification of the real estate appraisal report by the court of justice or by an administra-
tive body.
Based on the analysis of administrative courts’ judgements or decisions, it should be stated that
there is no uniform view developed in the jurisprudence of this issue. Various standpoints in this
matter can be observed: from the position limiting the possibility of examining the report to for-
mal issues only, to the position allowing the possibility of far-reaching interference with its sub-
stantive content (for instance, in the choice of approach, or valuation methods). The judgements
of the Supreme Court and common courts demonstrate an approach to the problem allowing
free discretionary assessment of evidence, without referring to specific issues regarding the as-
sessment of the content in either substantive (content-related) or formal terms. In the opinion of
the present authors, it is necessary to distinguish between the verification of the appraisal report
in terms of objective criteria from the examination in the scope of subjective criteria.
Spatial diversity of tourism attractiveness of the Nowy Sącz district, using the Wrocław taxonomic method
Authors: Gawroński Krzysztof , Król Karol , Gawrońska Grażyna , Leśniara Natalia
Published: September 2019

Designation of areas that are attractive from the point of view of tourism is possible by assessing
– among other things – the occurrence of tourist attractions in these areas, which become popu-
lar tourist destinations, as well as the presence of tourist infrastructure, which makes it possible
to take full advantage of these assets. Such assessment can be made on the basis of statistical data
analysis, carried out using taxonomic methods. The purpose of the study is to assess the spatial
diversity of tourism attractiveness of the Nowy Sącz district (poviat), including the city of Nowy
Sącz. The studies applied zeroed unitarization and Wrocław taxonomic method. It has been
demonstrated that the majority of the municipalities in the Nowy Sącz district show similarities
in terms of tourist attractiveness (according to the adopted research model).
Possible testing of geodetic equipment using the methods of mathematical statistics
Authors: Czempas Tomasz , Dwulit Petro , Krupiński Waldemar
Published: September 2019

The work presents selected methods of mathematical statistics applied to the examination of the
correctness of geodetic equipment operation.
Specifically, measurements made with electronic total stations will be tested using statistical
compatibility tests and identity tests of empirical measurement error distributions with the theo-
retical normal distribution N (0;1).
Interactive image viewers — comparison of selected tools and application examples
Authors: Król Karol , Bitner-Fiałkowska Agnieszka
Published: September 2019

The tasks carried out by public administration units include information and education.
Multiple and direct transmission of information may affect the awareness of local communi-
ties. However, public administration units often struggle with the lack of skills in terms of using
generally available techniques and design tools that allow relatively easy and low-cost sharing
of maps on the Internet. The aim of the present research has been to analyse selected tools that
enable interactive presentation of raster maps in the form of an unattended (maintenance-free)
web application. Exploratory tests consisted in determining the applicability of selected tools
for the presentation of spatial data, as illustrated with the example of land cover analysis of the
Wolbrom Municipality (Poland). In conclusion, it was shown that the tested components aspire
to be maintenance-free and they serve primarily an information function. They can be used in
the presentation of environmental and socio-economic phenomena, as well as infographics or
geo-infographics, which require ad hoc publication online.
Accurate and Boundary Estimate of Communication Network Connectivity Probability Based on Model State Complete Enumeration Method
Authors: Batenkov Kirill
Published: October 2019

We consider one of communication network structure analysis and synthesis methods, based on the simplest approach to connectivity probability calculation – a method of full network typical state search. In this case, the typical states of the network are understood as the events of network graph connectivity and disconnection, which are simple graph chains and sections. Despite significant drawback of typical state enumeration method, which involves significant calculation complexity, it is quite popular at stage of debugging new analysis methods. In addition, on its basis it is possible to obtain boundary estimates of network connectivity probability. Thus, when calculating Asari–Proshana boundaries use full set of incoherent (top) and cohesive (bottom) communication network states. These boundaries are based on statement that network connectivity probability under same conditions is higher (lower) than that of network composed of independent disjoint (connected) subgraph complete set serial (parallel) connection. When calculating Litvak–Ushakov boundaries, only edge-disjoint sections (for upper) and connected subgraphs (for lower) are used, i.e. subsets of elements such that any element does not meet two-rods. This boundary takes into account the well-known natural monotonicity property, which is to reduce (increase) network reliability with decrease (increase) any element reliability. From a computational view point Asari–Proshana boundaries have huge drawback: they require references of all connected subgraphs to compute upper bounds and all minimal cuts for bottom, which in itself is non-trivial. Litvak–Ushakov boundaries are devoid of these drawback: by calculating them, we can stop at any searching step for variants of sets of independent connected and disconnected graph states.
Medical School Admissions: Defining the Future of Healthcare Delivery in the United States
Authors: Burkhardt John , Abir Mahshid , Durning Steven
Published: September 2019

This article was migrated. The article was not marked as recommended. Issue: Systemic health disparities in the U.S. are unlikely to be successfully addressed without evidence-based, multilevel policy interventions. To date, most research investigations and policy interventions have been focused on incentivizing career choice aimed at ameliorating health disparities and correcting medical bias in practicing doctors. Much less work has been undertaken on utilizing educational policy, practices and data to affect positive change "upstream" of the current practicing healthcare workforce. An underutilized area in educational policy and predictive analytic use is in the medical school admissions process. Admissions policies for selective educational institutions have been tailored in the past to provide for the public good and therefore represent a natural first intervention area. Evidence: In the past, numerous policies have been enacted to incentivize physician behavior in ways to produce more primary care physicians, increase the physician work force in underserved areas, and in general improve health care equity. Despite these interventions, health disparities because of physician workforce shortcomings persist. With regard to medical school admissions approaches, several current and past standards have demonstrated that the selection process can be modified to alter the incoming cohort of student-doctors. Implications: We propose that medical education policy has not been sufficiently leveraged to act in concert with existing health service-based interventions. Specifically, we argue the medical school admissions process represents an underutilized opportunity to fundamentally change the physician workforce and address downstream health care system issues. Expanding what may constitute desirable for selection based on societal needs versus academic credentials is one possible remedy to the current approach. An opportunity also lies in leveraging the power of large data methods to provide predictive analytical input into the admissions process. Reconceptualizing the admissions process in these ways could allow for a complementary strengthening of the current programs designed to ease health disparities. In addition to the continuation of current diversity-enrichment programs in health professional education, expansion to more novel and cross-disciplinary solutions, such as those discussed in this article, could be actively encouraged.
Pro-inflammatory cytokines and depression in myocardial infarction
Authors: Barbarash O. L. , Lebedeva N. B. , Karetnikova V. N. , Berns S. A. , Kashtalap V. V. , Barbarash L. S.
Published: October 2019

Aim. To assess the associations between inflammatory factors and anxiety (A) and depression (D) levels in patients with myocardial infarction (MI). Material and methods. The study included 100 MI patients, hospitalised with a diagnosis of Q-wave MI (mean age 62,0±1,3 years). The methods of psychosocial status assessment included Zung depression scale and SpielbergerKhanin personal and reactive anxiety scales. The inflammatory markers of interest included interleukins (IL) 1-beta, IL-6, IL-8, IL-10, and C-reactive protein (CRP). Results. D and A symptoms in the early post-MI stage were associated with higher risk of cardiovascular events in the following year. Among MI patients with comparable MI severity, D and A symptoms were linked to higher levels of pro-inflammatory cytokines IL-1-beta, IL-8, IL-8, and INF-gamma. Conclusion. In MI patients with D and A symptoms, one of the mechanisms of poor prognosis is an activation of subclinical inflammation.
Blood pressure in patients with brachiocephalic atherosclerosis before and after the intervention
Authors: Kosacheva N. B. , Tuev A. V. , Agafonov A. V. , Mukhamadeev I. S.
Published: October 2019

Aim. To investigate the associations between brachiocephalic atherosclerosis (BCAS) and arterial hypertension (AH); to study the potential for AH control after surgery. Material and methods. The study included 70 patients (17 women, 53 men; mean age 62,5±7,5 years), who underwent planned surgery due to BCAS and carotid stenosis, CS (n=50) or brachiocephalic artery (BCA) malformation (n=20). AH duration varied from 4 months to 32 years. Levels of systolic blood pressure (SBP) were 115-192 mm Hg (mean SBP 151,5±27,26 mm Hg). Blood flow in aortal arch arteries was assessed by duplex BCA scanning. BP levels were registered within the 24 hours before the surgery, and then 3-5 days and 1-3 months after the intervention. Results. In patients with CS, risk of BP elevation increased with age (р=0,04). Before the surgery, higher BP levels were registered in Group I patients: mean BP was 103,6±11,3 mm Hg vs. 91,7±6,6 mm Hg (р=0,00007). After the intervention, these differences were no longer observed. In patients with CS, post-intervention BP levels decreased due to reduction in both systolic BP (from 145,1±14,7 to 135,6±12,3 mm Hg; р=0,02) and diastolic BP (from 83,3±10,2 to 78,1±9,7 mm Hg; р=0,02). In patients with BCA malformation, no significant BP reduction was registered.

Conclusion. In BCAS patients, BP elevation was mostly explained by CS and progressed with age, while surgery facilitated BP reduction.
Zofenopril in the treatment of patients with arterial hypertension and stable coronary heart disease: effects on oxidative stress and flowdependent vasodilatation
Authors: Ageev F. T. , Ovchinnikov A. G. , Plisyuk A. G. , Arzamastseva N. E. , Kulev B. D. , Kuz’mina A. E. , Patrusheva I. F.
Published: October 2019

Aim. To compare the effects of ACE inhibitors zofenopril and perindopril on endothelial function and oxidative stress (OS) in patients with stable CHD and AH. Material and methods. In total, 40 patients with stable CHD (Functional Class II-III effort angina) and Stage 1-2 AH received zofenopril (7,5-30 mg/d; mean dose 18,6±8,8 mg/d; n=17) or perindopril (2-8 mg/d; mean dose 4,1±2,1 mg/d; n=23) for 12 weeks. At baseline and in the end of the study, all patients underwent reactive hyperemia test (RHT), to assess flow-dependent vasodilatation of brachial artery, and the measurement of OS parameters (malone dialdehyde, MDA, in low-density lipoproteins, MDALDL) and antioxidant parameters (superoxide dismutase (SOD) and glutathione peroxidase (GPO) activity in erythrocytes).

Results. In both groups, a similar reduction in systolic and diastolic blood pressure levels was observed. In the zofenopril group, a significant elevation in brachial artery diameter increase during RHT, a significant increase in GPO activity, and some reduction in MDALDL levels were observed, which points to antioxidant system (AOS) activation and OS reduction. No similar changes of these parameters were observed in the perindopril group. Conclusion. In patients with stable CHD and AH, zofenopril, but not perindopril, reduced OS severity and increased AOS system activity, which was associated with improved endothelial-dependent vasodilatation.
Effectiveness of the original trimetazidine MR in patients with stable coronary heart disease and angina attacks resistant to trimetazidine generics (ETALON study)
Authors: Fendrikova A. V. , Skibitskyi V. V.
Published: October 2019

Aim. To assess the clinical benefits of the original trimetazidine medication (Preductal® MR) in patients with stable coronary heart disease and angina attacks resistant to trimetazidine generics. Material and methods. The study included 112 patients with stable coronary heart disease (CHD), who experienced angina attacks, despite the treatment with trimetazidine generics added to the standard CHD therapy (antiaggregants, statins, β-аadrenoblockers, ACE inhibitors). All participants received Preductal® MR (35 mg twice a day) instead of trimetazidine generics. The follow-up duration was 3 months. Treatment effectiveness was assessed by the changes in angina attack incidence, short-acting nitrate consumption, and general status, using a visual analogue scale (VAS). In addition, pharmaco-economic analysis of the treatment effectiveness was performed. Results. The replacement of trimetazidine generics with Preductal® MR was associated with a reduction in angina attack incidence by 63 % and in the number of nitroglycerine tablets/doses by 65 % (p<0,01). VAS score increased from 45,3±13,8 to 71,6±11,9 (р<0,0001). Preductal® MR therapy is the best pharmaco-economic option, since the ratio between weekly treatment costs (RUB) and the weekly number of prevented angina attacks is minimal for this original medication. Conclusion. In patients with stable CHD and angina attacks, resistant to trimetazidine generics, Preductal® МR therapy is associated with a significant reduction in angina attack incidence and consumption of short-acting nitrates. Preductal® MR is the most cost-effective medication, providing optimal effectiveness with minimal costs.
Effects of the fixed-dose combination therapy with indapamide and valsartan on renal function in patients with Type 2 diabetes mellitus and arterial hypertension
Authors: Malykh T. V. , Babkin A. P.
Published: October 2019

Aim. To study the effects of the fixed-dose combination antihypertensive therapy (noliprel A forte, valsaforce, and indapamide) and the renal function dynamics in patients with Type 2 diabetes mellitus (DM-2) and arterial hypertension (AH). Material and methods. In total, 40 patients with DM-2 and AH were randomised into two groups: Group I received noliprel A forte, and Group II received valsaforce and indapamide for two months. The clinical effectiveness of the fixed-dose combination antihypertensive therapy was assessed by 24-hour blood pressure monitoring (BPM), blood biochemistry, and renal function parameters measured at baseline and 8 weeks after the start of the treatment. Results. The treatment was associated with a substantial reduction in BP levels, improved circadian BP profiles, and metabolic neutrality. The therapy with noliprel A forte resulted in markedly improved circadian BP profiles and renal function, as demonstrated by the microalbuminuria dynamics (Rehberg-Tareev test: by 11±0,56 ml/min; Cockgroft-Gault formula: by 12±0,36 ml/min; MDRD formula: by 10±0,16 ml/min/1,73 m2). Conclusion. In patients with DM-2 and AH, the therapy with noliprel A forte significantly improved renal function parameters.
Blood Pressure and Metabolic Effect of a Combination of Lercanidipine with Different Antihypertensive Drugs in Clinical Practice
Authors: Cicero Arrigo F.G. , Gerocarni Beatrice , Rosticci Martina , Borgh Claudio
Published: October 2019

The aim of this study is to assess the blood pressure (BP) and metabolic effects of lercanidipine when combined with other classes of first-line antihypertensive drugs in day-to-day clinical practice. For this study, we consecutively enrolled 162 patients with uncomplicated primary hypertension, who are partial responders to the treatment with lercanidipine over a period of 24 months. Patients were then allocated to the combination of lercanidipine (10–20 mg/day) with β-blockers, diuretics, angiotensin-converting enzyme inhibitors, and angiotensin-II receptor blockers according to compelling indications (if any) and/or suggestions of European Society of Hypertension–European Society of Cardiology (ESH–ESC) guidelines. All the enrolled patients completed the study and no adverse drug reaction was registered during the research period. The association of a second drug with lercanidipine determined an additional BP decrease of either systolic BP or diastolic BP independently from the type of drug added (P always <0.05). The additional effect of lercanidipine appears widely distributed with no significant differences in the size of BP decrease. From the metabolic point of view, the addition of a second drug did not determine a significant variation in the serum levels of total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol (P always >0.05). Conversely, a significant decrease in fasting plasma glucose and serum levels of triglycerides has been observed in patients where lercanidipine has been combined with an angiotensin-converting enzyme inhibitor or an angiotensin-II receptor blocker. In conclusion, in our study we observed that lercanidipine-based protocols are well tolerated and efficacious in reducing BP. Moreover, the association of lercanidipine with renin–angiotensin system blockers is also associated with significant improvements in triglycerides and fasting plasma glucose.
New perspectives in immunological diagnostics of coronary heart disease
Authors: Davydov S. I. , Tarasov A. A. , Emelyanova A. L. , Kiseleva M. A. , Babaeva A. R.
Published: October 2019

Aim. To assess the diagnostic value of immunological markers of endothelial dysfunction (ED) in various clinical variants of coronary heart disease (CHD). Material and methods. The study included 455 patients with various clinical variants of CHD. The control group (CG) included 70 individuals without clinical CHD symptoms. Solid-phase immunoenzymatic method was used for measuring the serum titres of Chlamydia pneumoniae (Cp), sulphated glycosamineglycanes (s-GAG), collagen (C), and hyaluronic acid (HA) antibodies. Results. In patients with acute coronary syndrome (ACS), mean titres of Cp, s-GAG, C, and HA antibodies were significantly higher than in patients with chronic CHD or CG participants. Among patients with myocardial infarction (MI), the levels of troponin I (TrI) and MB-creatine phosphokinase (MB-CK) significantly correlated with the titres of s-GAG and C antibodies, while the levels of C-reactive protein (CRP) were linked to the titres of C and HA antibodies. In ACS with ST segment elevation, the measurement of Cp, s-GAG, C, and HA antibodies was comparable to the measurement of CRP, TrI, or MB-CK activity, being significantly more sensitive than echocardiography (EchoCG). In non-ST ACS, immunological parameters were as sensitive as electrocardiography or CRP measurement, more reliable than MB-CK activity measurement or EchoCG, and slightly less reliable than TrI measurement. In unstable angina pectoris (UAP), immunological analysis was significantly more sensitive than the majority of the standard diagnostic methods. Conclusion. Pathogenetic mechanisms of ACS are closely related to the development of specific autoimmune reactions. The assessed immunological parameters could be used as objective markers of acute CHD variants.
Conflict of interest policies and disclosure requirements among European Society of Cardiology national cardiovascular journals
Authors: Alfonso Fernando , Timmis Adam , Pinto Fausto J. , Ambrosio Giuseppe , Ector Hugo , Kulakowski Piotr , Vardas Panos
Published: October 2019

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Role of selected parameters and integral indices of treadmill test in the assessment of complication risk among patients with chronic coronary heart disease
Authors: Martsevich S. Yu. , Tolpygina S. N. , Malysheva A. M. , Polyanskaya Yu. N. , Hofmann E. A. , Lerman O. V. , Mazaev V. P. , Deev A. D.
Published: October 2019

Aim. To identify the value of selected parameters and integral indices of treadmill test (TT), such as Duke Treadmill Score (DTS), Centre for Preventive Medicine index (CPMI), and modified CPMI, in the assessment of cardiovascular complication (CVC) risk among patients with chronic coronary heart disease (CCHD). Material and methods. The study included all consecutive patients with the admission diagnosis of CCHD (n=260), who underwent coronary angiography (CAG) and TT in the period from January 1st 2004 to December 31st 2007, and were permanent residents of Moscow City or Moscow Region. Primary end-point was death from all causes; non-fatal CVC included acute myocardial infarction, acute cerebrovascular accident, and revascularization (percutaneous coronary intervention or coronary artery bypass graft surgery). Results. The mean time to the development of primary end-point was 3,2 years; it total, it was registered in 71 patients (32,0 %). The incidence of primary end-point was higher in patients with ST segment depression ≥1 mm at TT, positive TT result, or chest pain development during the test. Achievement of target heart rate and TT time ≥12 minutes was associated with a better prognosis. In patients with high and intermediate risk by DTS and CPMI, the incidence of primary end-point was higher than in patients with low risk. Modified CPMI demonstrated high correlation with the primary end-point. Conclusion. The highest prognostic value in the assessment of the risk of CCHD complications was demonstrated by TT result, ST segment depression ≥1 mm, TT time, and chronotropic TT response. The role of CPMI and modified CPMI as predictors of CVC risk in CCHD patients was assessed.
Stress-related hemodynamic response in healthy young individuals with Type D personality
Authors: Sumin A. N. , Sumina L. Yu. , Barbarash N. A.
Published: October 2019

Aim. To investigate the association between the stress-related hemodynamic response during the mental calculation test (MCT) and the presence of Type D personality in healthy young individuals. Material and methods. The study included 80 healthy individuals (19 men and 61 women; mean age 18,8±0,2 years). Psychological status examination included the DS-14 scale, depression scale, and Spielberger-Khanin scale. MCT was performed with simultaneous assessment of hemodynamic response. Results. Type D personality (distressed type) was observed in 32,5% of the participants. Among young students, Type D personality was associated with higher levels of trait and state anxiety (TA and SA), as well as higher depression scale scores, compared to students without Type D personality. Type D personality was also linked to a more pronounced response of systolic blood pressure (SBP) during MCT (p=0,05). There was a strong correlation between social inhibition levels and maximal heart rate (HR) during MCT (r=-0,238; p=0,034). Young men demonstrated a moderate correlation between Type D personality and HR response (r=-0,508; p=0,026), as well as between negative affectivity levels and HR response during MCT (r=0,469; p=0,043). Conclusion. Distressed personality type was observed in one-third of healthy young participants of the study. Type D personality and its subscales correlated with the hemodynamic response during MCT, with some gender-specific features observed. These findings clarify potential mechanisms of Type D personality effects on the development and prognosis of cardiovascular disease.
Comparative analysis of arteriolar Doppler ultrasound parameters in hypertensive patients with or without Type 2 diabetes mellitus
Authors: Volkov V. S. , Rudenko E. V. , Poselyugina O. B.
Published: October 2019

Aim.Using the Doppler ultrasound method, to describe functional status of arterioles in patients with essential arterial hypertension (AH) and individuals with Type 2 diabetes mellitus (DM-2) and concomitant AH.Material and methods.The study included 90 AH patients and 83 patients with DM-2 and AH. Systolic (Vs, cm/s), diastolic (Vd, cm/s), and mean (Vm, cm/s) arteriolar blood flow velocity was measured using the Miniplex Doppler device. The subsequent spontaneous changes in blood flow velocity were registered for one minute and presented as percentages.Results.The maximal blood flow velocity was observed in AH patients, followed by healthy controls and patients with DM-2 and AH. The Vs variation was the largest in healthy people, smaller in AH patients, and the smallest in participants with AH and DM-2. The maximal Vd variation was observed in AH patients, followed by patients with AH and DM-2 and healthy controls.Conclusion.The assessment of arteriolar blood flow velocity provides information about arteriolar tonus and its dynamics over time.
Risk factors of adverse cardiovascular prognosis in patients with peripheral artery disease
Authors: Askarov A. R. , Nelaev V. S. , Rudneva L. F. , Shalaev S. V.
Published: October 2019

Aim. To prospectively study the prevalence and clinical manifestations of the risk factors (RFs) of adverse cardiovascular prognosis in patients with peripheral artery disease (PAD) of varied severity. Material and methods. The study included 78 patients with Stage 2-4 PAD, aged 38-70 years. The following cardiovascular RFs were analysed, using standard clinical, laboratory, and instrumental methods: arterial hypertension (AH), smoking, family history of premature coronary heart disease (CHD), hypercholesterolemia (HCH), disturbed carbohydrate metabolism, low physical inactivity (LPA), heart rate (HR) >70 beats per minute (bpm), abdominal obesity (AO), metabolic syndrome (MS), blood hypercoagulation, and elevated levels of high-sensitivity C-reactive protein (hsCRP). Results. In most PAD patients, atherosclerosis had multiple localization (75,0%). There was an association between duration of the disease, its severity, and disabled status. The prevalence of cardiovascular RFs was high: 94,0% for HCH, 90,0% for AH, 89,0% for smoking, 58,0% for premature CHD in family history, 81,0% for hyperfibrinogenemia, 73,0% for HR >70 bpm, 73,0% for MS, 73,0% for increased pulse blood pressure, 67,0% for overweight, 77,0% for LPA, and 53,0% for elevated hsCRP levels. The one-year follow-up data demonstrated a high incidence of cardiac (30,0%) and vascular (28,0%) complications. The three most important RFs of adverse cardiovascular prognosis included AH progression, CHD, and intermittent claudication. Conclusion. The high prevalence of multifocal atherosclerosis (approximately 75%), AH, CHD, and MS in PAD patients warrants the need for early detection and effective control of modifiable RFs, in order to prevent the progression of the disease and the development of cardiovascular complications.