bluuebunny/crossref_metadata_2025 huggingface dataset:
Adipokines of adipose tissue in the pathogenesis of obesity and coronary artery disease
Authors: Побожева И.А. , Пантелеева А.А. , Разгильдина Н.Д. , Полякова Е.А. , Драчева К.В. , Беляева О.Д. , Беркович О.А. , Баранова Е.И. , Пчелина С.Н. , Мирошникова В.В.
Published: November 2020

Дисбаланс в секреции адипокинов жировой тканью при ожирении может играть роль в развитии сердечно-сосудистых заболеваний. Нами было проведено исследование уровня экспрессии генов адипонектина и оментина-1 в жировой ткани у лиц с ожирением и ишемической болезнью сердца (ИБС). Показано, что сниженные концентрация в сыворотке крови и экспрессия гена адипонектина в подкожной жировой ткани могут вносить вклад в развитие ИБС при ожирении. ИБС ассоциирована с низкой концентрация оментина-1 в сыворотке крови.

Imbalance in the secretion of adipose tissue adipokines may play a role in the development of cardiovascular diseases associated with obesity. Investigation of adiponectin and omentin-1 genes expression levels in adipose tissue was conducted in patients with obesity and coronary artery disease (CAD). Our study has shown that reduced adiponectin serum concentration and subcutaneous adipose tissue gene expression may contribute to CAD development. CAD is associated with a low serum omentin-1 concentration.
Application of monomolecular sequencing technology to the diagnostics of hypertrophic cardiomyopathy
Authors: Салахов Р.Р. , Голубенко М.В. , Павлюкова Е.Н. , Марков А.В. , Бабушкина Н.П. , Канев А.Ф. , Валиахметов Н.Р. , Назаренко М.С.
Published: November 2020

В работе представлены результаты секвенирования пяти генов, ассоциированных с гипертрофической кардиомиопатией, с использованием технологии мономолекулярного секвенирования компании Oxford Nanopore Technologies. В результате анализа данных с помощью различных алгоритмов были выявлены миссенс-варианты в исследованных генах, которые могут являться причиной заболевания у пациентов.

The paper presents the results of sequencing of five genes associated with hypertrophic cardiomyopathy, using monomolecular sequencing (Oxford Nanopore Technologies). As a result of data analysis with various algorithms, missense variants were identified in the studied genes that may be the cause of the disease in the patients.
Neurofibromatosis genetic testing: cohort study
Authors: Карандашева К.О. , Пащенко М.С. , Аношкин К.И. , Кузнецова Е.Б. , Танас А.С. , Стрельников В.В.
Published: November 2020

Исследование проведено на материале ДНК периферической крови 1000 пациентов с клиническими признаками нейрофиброматоза 1-го типа или нейрофиброматоза 2-го типа. Молекулярно-диагностический комплекс включал высокопроизводительное параллельное секвенирование, мультиплексную амплификацию лигированных зондов, секвенирование по Сэнгеру. Клинический диагноз был подтвержден в 70,2% случаев, мутации в генах NF1 и NF2 были выявлены у 672 и 30 пациентов соответственно.

The study was conducted of DNA from peripheral blood of 1000 patients with clinical signs of neurofibromatosis type 1 or neurofibromatosis type 2. The genetic testing included massive parallel sequencing, multiplex ligation-dependent probe amplification, Sanger sequencing. The pathogenic mutation was identified in 70.2% of the cases, affecting NF1 and NF2 genes in 672 and 30 cases, respectively.
Transcriptome of breast tumor with different amplification statuses of long arm of chromosome 8
Authors: Ибрагимова М.К. , Цыганов М.М. , Литвяков Н.В.
Published: November 2020

Изучено изменение транкриптома опухоли молочной железы (РМЖ) с различным статусом амплификации длинного плеча 8 хромосомы (с локусом 8q24) и в процессе предоперационной химиотерапии. В исследовании использовались парные образцы биопсийного материала до лечения и операционного материала от 60 больных РМЖ люминального В подтипа, получавших 4-8 курсов неоадъювантной химиотерапии (НХТ). Показано, что в 65% случаев амплификация 8q сохраняется в опухоли после НХТ. Показаны топ-10 сигнальных путей дифференциально-экспрессируемых генов (ДЭГ) в опухоли больных РМЖ до лечения и после НХТ с наличием амплификации 8q. ДЭГ пациентов с различным статусом амплификации 8q (с регионом 8q24) до лечения и после НХТ пересекаются всего по 8 генам. В резидуальной опухоли у больных с амплификацией 8q было установлено повышение экспрессии генов стволовости GSK3B, MYC, GATA3, SMAD4, SMAD2, принимающих участие в WNT- и TGFb-сингналинге. Проведенное исследование показывает большое влияние амплификации длинного плеча хромосомы 8 на опухолевый транскриптом при РМЖ, независимо от других молекулярно-генетических признаков. Амплификация 8q с участием региона 8q24 приводит к значительному сдвигу уровня транскрипции большого количества генов именно после воздействия химиотерапии.

The aim of this work was to study changes in the breast tumor transcriptome and the amplification status of the long arm of chromosome 8 (with locus 8q24) and in the process of pre-surgery chemotherapy. The study used paired samples of biopsy material before treatment and surgical material from 60 patients with breast cancer of luminal B subtype who received 4-8 courses of NAC. It was shown that in 65% of cases, amplification of 8q is preserved in the tumor after NAC. Top-10 DEG signaling pathways in the tumor of breast cancer patients before treatment and after NAC with the presence of amplification of 8q are shown. DEG of patients with different amplification statuses of 8q (with region 8q24) before treatment and after NAC overlap in8 genes. In the residual tumor of patients with amplification of 8q, an increase in the expression of stemness genes GSK3B, MYC, GATA3, SMAD4, SMAD2 participating in WNT and TGFb syngnaling was found. The study shows a large effect of amplification of the long arm of chromosome 8 on the tumor transcriptome in breast cancer, regardless of other molecular genetic features. Amplification of 8q involving region 8q24 leads to a significant shift in the level of transcription of a large number of genes precisely after exposure to chemotherapy.
Hypoxia-inducible factor: analysis of the HIF1A and HIF1B single nucleotide polymorphisms and their functional role in development of uterine fibroids
Authors: Барышева Е.М. , Зайцев С.М. , Горяинова Н.В. , Пономарева Л.А. , Полшведкина О.Б. , Иванова О.Ю. , Бушуева О.Ю.
Published: November 2020

В исследование были включены 584 пациентки с миомой матки и 391 женщина контрольной группы. Генотипирование однонуклеотидных полиморфизмов (SNP) генов HIF1A и HIF1B (rs2301106, rs2301113, rs1951695, rs2057482, rs4899056 HIF1A и rs3738493, rs10847 HIF1B) было проведено методом ПЦР в режиме реального времени. Выявлен протективный эффект rs10847 HIF1B относительно риска развития миомы матки (OR=0,78, 95%CI=0,63-0,95; p=0,016). Обсуждаются молекулярные механизмы связи rs10847 HIF1B с патогенезом миомы матки.

A total of 584 patients with uterine fibroids and 391 healthy controls were recruited for the study. Genotyping of single nucleotide polymorphisms (SNPs) of the HIF1A and HIF1B genes (rs2301106, rs2301113, rs1951695, rs2057482, rs4899056 HIF1A and rs3738493, rs10847 HIF1B) was performed using real-time PCR). The protective effect of rs10847 HIF1B against the risk of uterine fibroids was revealed (OR=0.78, 95%CI=0.63-0.95; P=0.016). The molecular mechanisms of the involvement of rs10847 HIF1B to the pathogenesis of uterine fibroids are discussed.
Next-Generation Sequencing for somatic mutation detection in colorectal cancer and lung cancer
Authors: Жусина Ю.Г. , Аксенова Е.В. , Канивец И.В. , Пьянков Д.В. , Коростелев С.А.
Published: November 2020

Цель исследования - оценить распространённость редких мутаций в генах EGFR, KRAS, NRAS, BRAF, а также долю мутантного аллеля (AF) в образцах у пациентов с раком легкого и колоректальным раком. Методом секвенирования следующего поколения (NGS) (NGS) было исследовано 199 образцов ДНК, выделенной из парафиновых блоков, содержащих образцы опухоли. Редкие мутации при колоректальном раке выявлены у 12,8% пациентов; 20% образцов имели AF<15%. Редкие мутации при раке легкого найдены у 24,2% пациентов; 27% образцов имели AF<15%. NGS может быть рекомендовано как рутинный метод исследования соматических мутаций в опухоли. NGS обладает большими диагностическими возможностями в сравнении с ПЦР-тестами или секвенированием по Сэнгеру.

Study objective is to assess the prevalence of rare mutations in the EGFR, KRAS, NRAS, BRAF genes, as well as the proportion of the mutant allele frequency (AF) in the samples of patients with lung cancer and colorectal cancer. Materials and Methods: 199 samples of DNA isolated from paraffin blocks was studied using next generation sequencing. Study Results: rare mutations in colorectal cancer were detected in 12.8% of patients. 20% of the samples had AF <15%. Rare mutations in lung cancer were observed in 24.2%. 27% of the samples had AF <15%. Conclusion: Next Generation Sequencing (NGS) may be recommended as a routine method for detecting somatic mutations in a tumor. NGS has great diagnostic capabilities compared to PCR or Sanger sequencing.
Ultra-Low Molecular Weight Photoswitchable Hydrogelators
Authors: Larik Fayaz , Fillbrook Lucy , Nurttila Sandra , Martin Adam D , Kuchel Rhiannon P. , Taief Karrar Al , Bhadbhade Mohan , Beves Jonathon , Thordarson Pall
Published: November 2020

Photoswitchable arylazopyrozoles 2 and 3 form hydrogels at a concentration of 1.2% (w/v). With a molecular weight of 258.11 g/mol, these are the lowest known molecular weight hydrogelators that respond reversibly to light. Single-crystal X-ray structures show anisotropic aggregation of 2 and 3 is driven by in-plane hydrogen bonding interactions and 𝝅 - 𝝅 stacking. Photoswitching of 2 and 3 from the E- to the Z-form by 365 nm light results in a macrocopic gel→sol transition; nearly an order of magnitude reduction in the measured elastic and loss moduli. Cryogenic transmission electron microscopy suggests that the 29±7 nm wide sheets in the E-2 gel state narrow to 13±2 nm upon photoswitching to the predominantly Z-2 solution state. In the case of 2, photoswitching is reversible through cycles of 365 nm and 520 nm excitation with little fatigue. The release of a Rhodamine B dye encapsulated in gels formed from 2 and 3 can be accelerated more than 20-fold upon photoswitching with 365 nm light, demonstrating these materials are suitable for light-controlled cargo release.
Development and Benchmarking of Open Force Field v1.0.0, the Parsley Small Molecule Force Field
Authors: Qiu Yudong , Smith Daniel , Boothroyd Simon , Jang Hyesu , Wagner Jeffrey , Bannan Caitlin C. , Gokey Trevor , Lim Victoria T. , Stern Chaya , Rizzi Andrea , Lucas Xavier , Tjanaka Bryon , Shirts Michael R. , Gilson Michael , Chodera John , Bayly Christopher I. , Mobley David , Wang Lee-Ping
Published: November 2020

We describe the structure and optimization of the Open Force Field 1.0.0 small molecule force field, code-named Parsley. Parsley uses the SMIRKS-native Open Force Field (SMIRNOFF) parameter assignment formalism in which parameter types are assigned directly by chemical perception, in contrast to traditional atom type-based approaches. This method provides a natural means to incorporate increasingly diverse chemistry without needlessly increasing force field complexity. In this work, we present essentially a full optimization of the valence parameters in the force field. The optimization was carried out with the ForceBalance tool and was informed by reference quantum chemical data that include torsion potential energy profiles, optimized gas-phase structures, and vibrational frequencies. These data were computed and are maintained with QCArchive, an open-source and freely available distributed computing and database software ecosystem. Tests of the resulting force field against compounds and data types outside the training set show improvements in optimized geometries and conformational energetics and demonstrate that Parsley's accuracy for liquid properties is similar to that of other general force fields.
Consecutive Photocatalysis vs Electro-Photocatalysis. Excitation of Radical Anions of Naphthalene Diimides.
Authors: Caby Sofia , Bouchet Lydia M. , Argüello Juan E. , Rossi Roberto A. , Bardagi Javier
Published: November 2020

Photo- and electrochemical transformations represent excellent opportunities for the development of methodologies environmentally friendly and combination of both techniques would result in improved methodologies. Recently, photochemical transformations involving the excitation of open-shell species has become a reality. Photostimulated electron transfer (PET) from radical anions of organic dyes have been used in consecutive photoredox catalysis and electro-photocatalysis transformation, allowing the transformation of aryl halides in valuable compounds under mild conditions. The similarities of both techniques raises the question of the convenience of using one or other related and a close evaluation is necessary to drive further development and have been shyly done in previous works. However, an objective comparison of both approaches will require using the same chemical system. We present here a direct comparison of a “pure” photochemical and an electrophotochemical transformartion studying a model transformation, namely, a C-H substitution in (hetero)aromatic systems with a C-C bond formation through reaction of halogenated substrates. Through a detailed investigation of both mechanisms, we identify a system that could be applied in both approaches with minor (necessaries) changes in the reaction conditions and clearly identify the excitation of radical anion of naphthalene diimides as the key intermediates. Both approaches are comparable in yields and kinetics with slightly better yields for the consecutive PET reaction and better selectivity for the electro-PET process. Our work offers a system that could be used for a more profound comparison of the experimental setups which could include, for instance, the important factor of energy consumption.
STopTox: An In-Silico Alternative to Animal Testing for Acute Systemic and TOPical TOXicity
Authors: Borba Joyce V. V. B. , Alves Vinicius , Braga Rodolpho , Korn Daniel , Overdahl Kirsten , Silva Arthur C. , Hall Steven , Overdahl Erik , Strickland Judy , Allen DAvid , Kleinstreuer Nicole , Andrade Carolina , Muratov Eugene , Tropsha Alexander
Published: November 2020

Since 2009, animal testing for cosmetic products has been prohibited in Europe, and in 2016, US EPA announced their intent to modernize the so-called "6-pack" of acute toxicity tests (acute oral toxicity, acute dermal toxicity, acute inhalation toxicity, skin irritation and corrosion, eye irritation and corrosion, and skin sensitization) and expand acceptance of alternative methods to reduce animal testing of pesticides. We have compiled, curated, and integrated the largest publicly available dataset and developed an ensemble of QSAR models for all six endpoints. All models were validated according to the OECD QSAR principles and tested using newly identified data on compounds not included in the training sets. We have established a publicly accessible Systemic and Topical chemical Toxicity (STopTox) web portal (https://stoptox.mml.unc.edu/) integrating all developed models for “6-pack” assays. This portal can be used by scientists and regulators to identify putative toxicants or non-toxicants in chemical libraries of interest.
El enriquecimiento sin causa en el contexto del contrato: a propósito del pago en exceso
Authors: Barchi Velaochaga Luciano Juan Luis
Published: November 2020

El autor a través de este artículo pretende demostrar cómo es que dentro del ámbito de los contratos se originan pretensiones restitutorias que tienen como fundamento relaciones obligatorias generadas en principio por fuentes heterónomas como el convenio arbitral, profundizando su análisis concretamente del pago en exceso.
Preparation and Investigation of the Effect of Polyherbal Syrup Formulation on Brain Enzymes
Authors: Purushothaman M  , Madhusudhan M  , Kathiravan P  , Sravanthi CH  , Srikanth Choudary P
Published: November 2020

Convulsions and seizures are the major neurological conditions that are the symptoms of brain diseases like brain stroke, aneurysm and other oxidative brain damage. This affects most of the people in the world as a symptom of other diseases and as a disorder on its own. Herbs are found to be the alternatives of the synthetic drugs that cause the side effects and are common in synthetic drugs as discussed above. So herbal extracts are safe and potent and do not contain or contain a very less amount of side effects. So, they can be used effectively in treating many conditions, including epilepsy. Most of the herbs show their potency by exhibiting the antioxidant activity. Since the oxidative free radicals that are generated in the brain are the cause of disturbance in the protective enzymes in the brain, the estimation of the protective enzymes in the brain during epilepsy. This work was carried out to prepare an effective polyherbal syrup to treat epilepsy effectively. The formulation was tested in 2 doses of 100 and 200mg, and they are also investigated for the activity to normal the enzymes that are in the brain, which help to fight the free radicals. From this, it can be advocated that the herbs in the syrup helped the formulation's antioxidant activity to attribute to the anti-epileptic activity in experimental animals.
疫情背景下乳制品行业内部控制失效动因及对策研究
Authors: 宋 森
Published: November 2020

现阶段，人们对生活水平和要求越来越高，也越来越重视食品安全问题，尤其是乳制品行业食品安全问题得到重视。在疫情期间乳制品行业如何提升企业内部控制，加强食品安全有效管理，成为乳制品企业一个重要的问题。然而，中国内部控制理论相较其他国家起步的较晚,发展的也不够完善。为了使中国的企业顺应国家及社会的发展，就要对内部控制制度引起注意。
高校做好增收节支工作的措施
Authors: 刘 佩 , 王 滨韬
Published: November 2020

为了更好地开展增收节支工作，充分挖掘增收潜力，厉行勤俭节约，促进资金使用效益最大化，中国高校需要全面排查制约本单位增收节支的问题和瓶颈，同时深入挖掘增收节支的关键点，并提出相关解决措施和建议。
企业经济管理的信息化路径探索
Authors: 刘 怀忠
Published: November 2020

随着科学技术水平的提升，中国步入了信息化时代。随着经济实力的增强，市场经济体制进行了一系列改革，对于企业有了新的标准。在这一情况下，企业想要在竞争中占据优势，就必须做好经济管理工作，提高经济管理信息化水平，满足经济市场进一步发展需要。论文简要分析传统经济管理模式出现的不足，探究了企业经济管理信息化水平路径，希望能提高企业经济管理水平，为企业的长期稳定发展提供支持。
事实孤儿社会保护可行性研究和对策建议
Authors: 朱 梦瑶
Published: November 2020

事实孤儿指的是事实上无人抚养的儿童，通常指父母没有伤亡，但是没有意愿抚养和没有能力抚养的儿童。根据中国相关法律法规的规定，从2020年1月1日起，全面实施对无人抚养儿童的保护。但从具体实施情况来看，仍然存在很多问题和困难，影响对事实孤儿社会保护的效果。论文针对事实孤儿社会保护可行性进行探求，并指出具体的实施策略，希望能为事实孤儿的健康成长提供一定的参考。
大学生创新创业过程中重构用户体验的路径和方法----以小罐茶为例
Authors: 王 啸然
Published: November 2020

大学生在创新创业的过程中，对于用户体验往往难以摸索出一条行之有效的路径，在用户体验上表现出体验门槛较高、体验步骤不清晰、或是同质化产品的相似体验不能给客户带来具有新鲜感的体验；在用户体验的方法论上欠缺自成体系的方法论，不能形成一套以用户体验为导向的产品销售及研发的闭环，这大大影响了大学生在创新创业过程中对于产品推广及增长的难度，而且基于价值网络的牵引力，往往使大学生在最后又重回到主流价值网的引力当中，最后导致初创企业被巨头企业扼杀的摇篮里。
试论博物馆文旅融合现状和对策
Authors: 戚 颖群
Published: November 2020

2018年，根据国务院机构改革方案，文化和旅游部正式挂牌，开启了文化和旅游融合发展的大幕，“文旅融合发展”已经成为现时文化旅游界的关键词。博物馆充分认识到当前形势下自身在文旅融合发展中的神圣使命，大力普及和倡导文旅融合理念，努力思考在文旅融合背景下的发展方向。论文对博物馆文旅融合现状进行了分析，并进一步探讨深化博物馆文旅融合发展的思路和对策。
漫谈中国文化在陶瓷设计中的传承
Authors: 于 航
Published: November 2020

中国陶瓷艺术文化历史悠久、源远流长，这与中国深厚的文化基础有直接联系。正是因为对中国文化的应用与传承，才使中国陶瓷艺术独具特色、经久不衰。论文联系实际，就新时代背景下中国文化在陶瓷设计中的应用与传承做简单分析研究，以期为相关工作的开展带来些许帮助。
航海运输专业群教育实践路径
Authors: 熊 正华 , 凤 勇 , 向 波
Published: November 2020

海运是中国对外贸易的重要形式，现如今中国对海运提出了更高的要求。当前，中国船舶工业和航运业在智能船舶领域进行了探索，相关科研攻关取得积极进展，智能技术工程应用初显成效，已形成一定的技术积累和产业基础，基本与国际先进水平保持同步。但是，全球智能船舶的发展仍旧处于探索阶段，智能技术工程应用十分有限，这是当前航海运输发展面临的挑战，需要从当前教育形式出发，探索专业群教育，让航海运输专业能跨出当前专业限制，逐渐走向综合性的发展方向，为中国的航海运输奠定坚实的人才基础。论文主要从航海运输专业群教育实践原则以及航海运输专业群教育实践路径这两方面进行了详细阐述。
Exploring the coach’s and athletes’ behaviour in martial arts
Authors: Romar Jan-Erik , Ranta-Aho Markus , Williams Emyr
Published: November 2020

This descriptive study examined the
processes of coaching and participation in Brazilian jiu-jitsu (BJJ) for both
experienced (n=3) and novice (n=3) adult participant, members of a martial arts
club in Finland. Over a period of six weeks, five practice sessions were
videotaped with a mean duration of 84.35 minutes. Systematic observation data were used to describe the practice
structure and participants’ engagement. Additionally, a modified version of the
Coach Analysis and Intervention System was used to evaluate coaching behaviour.
The heart rate data were also collected to evaluate the participants’ physical
activity levels. Results indicated that practice time allocated to training and
playing were 75% and 25%, respectively, which differs from team sport research.
The coaching emphasis observed in this study highlighted competition and
technique perfection. The participants’ practice activity level was high with
most participants spending more than half of practice time at a moderate-to-vigorous
physical activity level. These findings show that both the structure and
content of coaching practice is context specific and that the coach need to
identify and react to the needs of individual athletes.
التكيف الاجتماعي والوظيفي للشباب السعودي في وظائف التوطين وفقاً لرؤية 2030
Authors: Sahl Al-Qous Saud
Published: November 2020

تهدف هذه الدراسة إلى تقصي مدى تكيف الشباب السعودي اجتماعيًّا ووظيفيًّا في وظائف التوطين وفقًا لرؤية المملكة 2030، والتأكد من مدى وجود فروق ذات دلالة إحصائية تعزى لمتغيرات الجنس والمستوى التعليمي، ومستوى الدخل الشهري لأفراد العينة؛ ولتحقيق هذه الأهداف استخدم الباحث المنهج الوصفي، مع الأخذ بطريقة المسح الاجتماعي من خلال العينة الممثلة لمجتمع البحث، واستخدم الباحث في جمع البيانات المطلوبة استبانة مؤلفة من 32 فقرة تقيس أربعة أبعاد للتكيف، وتوصلت الدراسة إلى أن المتوسط العام لتكيف الشباب السعودي في وظائف التوطين هو 3.36، ويقع في فئة «متوسط». وتشير استجابات أفراد العينة بخصوص أبعاد التكيف الأربعة إلى أن الشباب السعودي يتكيف ذاتيًّا واجتماعيًّا بمستوى «مرتفع» ويتكيف اقتصاديًّا ووظيفيًّا بمستوى «متوسط». كما وافق أفراد العينة على جميع عبارات معوقات التكيف بنسب مرتفعة، وخلصت الدراسة من مجمل النتائج المتعلقة بأبعاد التكيف ومعوقاته إلى أن الأسباب التي جعلت الشباب السعودي لا يصل إلى المستوى المرتفع للتكيف في وظائف التوطين لا تعود إلى أسباب ذاتية واجتماعية، وإنما تعود إلى أسباب اقتصادية ووظيفية تتعلق ببيئة العمل في المقام الأول، وقد اكتشفت الدراسة وجود فروق ذات دلالة إحصائية للتكيف الاجتماعي والوظيفي للشباب السعودي في وظائف التوطين لصالح الإناث والحاصلين على مؤهلات أقل وذوي الدخول الأعلى، وأوصت الدراسة في ضوء نتائجها بعدد من التوصيات.
TUBERCULOSIS MIMICKING A TESTICULAR TUMOR
Authors:   1National Hospital of Sri Lanka.
Published: November 2020

Genitourinary tuberculosis is a challenging clinical entity which can affect the entire male genital tract. Seventy-five- year old male presented with a testicular lump masquerading a testicular malignancy. Histological and microbiological examination of testicular biopsy specimens established the diagnosis of tuberculosis. Isolated testicular tuberculosis is rarely reported. High degree of clinical suspicion and histological sampling are paramount important in the process of diagnostic evaluation.
ПЕРСПЕКТИВЫ ИСПОЛЬЗОВАНИЯ РОБОТИЗИРОВАННОГО ДОЕНИЯ В МАЛЫХ ФОРМАХ ХОЗЯЙСТВОВАНИЯ
Authors: Komlatsky Grigory Vasilievich , Melnichenko Anton Aleksandrovich , Lazarev Dmitry Olegovich
Published: November 2020

In the conditions of a peasant farm, a research and production experiment was carried out, the purpose of which was to determine the milk productivity of Holstein cows of Danish selection using a robot milker. It was found that the milk yield of the first lactation cows was within 8237 kg. Taking into account the fact that milk productivity increases in subsequent lactations, it can be concluded that the innovative technology of robotic milking in a family farm allows the genetic potential of animals to be fully realized. The data obtained are consistent with the results of other researchers, which confirms their reliability. The adaptation of animals to robotic milking took place within a month, while the observations of the behavior of cows showed that out of 40 cows, 18 animals voluntarily visited the robotic milker 2 times a day. 22 out of 40 cows had 3 visits. Only 2 cows from the whole group went to milking only once a day. According to the observations of the duration of the milking session, it was found that the time spent by the cows visiting the robotic milker varied on average from 3 to 15 minutes. Moreover, the interval of 5-7 minutes accounts for more than half of all visits. Visits are both shorter (less than 5 minutes) and extended (10 minutes or more). Gentle udder treatment and placement of teat cups not only ensure good udder health, but also improve milk quality. Self-service technology gives animals the right to choose the timing and frequency of visits to the robotic milking station, significantly reduces the stress situation and increases the productivity and quality of milk. The data obtained confirm the feasibility of using a high-tech milk milking scheme in family farms and other small forms of farming. Grants and other forms of financial support from the regional administration will contribute to the further introduction of robots into the livestock system.
The rationale for the loading modes of diesel engines for the diagnosis at unsteady load
Authors: Saveliev Anatoly Petrovich , Shkrabak Vladimir Stepanovich , Shkrabak Roman Vladimirovich , Glotov Sergey Viktorovich , Enaleeva Svetlana Anatolyevna
Published: November 2020

To increase the reliability of diagnosing tractor engines, a dynamic loading mode is proposed under bench conditions. The loading modes are substantiated from the point of view of diagnostics of the input action and the most informative mode of engine operation.
Use of remote methods for monitoring formation of yield of spring barley
Authors: Storchak Irina Gennadyevna , Eroshenko Fedor Vladimirovich
Published: November 2020

When cultivating barley, there is a need to monitor the condition of crops and forecast yields using objective and inexpensive methods. Remote sensing data of the Earth is used to solve various problems in the agricultural sector related to monitoring vegetation, including monitoring the condition of agricultural crops throughout the growing season. The main advantages of this observation are: efficiency, objectivity, multi-scale and cost-effective. The question of the possibility of predicting crop yields in the scientific literature has not yet been adequately reflected. Therefore, the purpose of the research was to identify the relationship between the data of remote sensing of the Earth and the yield of spring barley for the conditions of the Stavropol Territory. The studies used data from the VEGA IKI RAS service (averaged NDVI values of spring crops in the Stavropol Territory) and the statistical office of the Stavropol Territory. In the analysis of materials, NDVI values were tied to the stages of organogenesis. It was found that the closest correlation between (0.64) NDVI and spring barley yield corresponds to the phase of the formation of the caryopsis. When analyzing yield data and values of the NDVI vegetation index on fixed calendar dates (weeks) of the year, it was shown that a statistically significant correlation appears between the 13th and 26th calendar weeks of the year. Therefore, the Stavropol Territory is characterized by the dependence of barley productivity on NDVI values of spring crops. The closest it is observed in the phase of the formation of the seed. Thus, for the conditions of the Stavropol Territory, it is possible to predict the yield of spring barley according to remote sensing data of the Earth.
Substantiation of the terms of effective use of insecticides in the fight against cabbage moth in spring rape crops
Authors: Churikova Vera Gennadievna , Silaev Alexey  Ivanovich
Published: November 2020

The biology of development of cabbage moth in crops of spring rape in the Volga region is shown. The relationship between the development of the phytophage and the host plant has been studied for a long period. The terms of use of means of protection are substantiated, providing a higher efficiency of insecticides in the fight against caterpillars of P. maculipennis.
Influence of vitamin-mineral premix “SulfVita” on some hematological and biochemical indicators of bulls of Kazakh white-headed breed
Authors: Molchanov Alexey Vyacheslavovich, , Sazonova Irina Aleksandrovna , Kozin Anton Nikolaevich , Egorova Karina Alekseevna
Published: November 2020

Hematological and biochemical parameters of the blood of bulls of the Kazakh white-headed breed were studied after the introduction of the vitamin-mineral premix "SulfVita" into the diet. Animals that received the premix "SulfVita" along with the main diet, at a concentration of 1%, surpassed their peers in terms of hemoglobin and erythrocyte levels, and the intensity of protein metabolism.
Prevalence and Factors Associated with Comorbid Depression and Anxiety Among Adults in South-western Nigeria: A Community-Based Study
Authors: Akinsulore A , Adeseiye OC , Oloniniyi IO , Esimai OA
Published: November 2020

Background: Depression and anxiety are common mental disorders that frequently occur in the elderly. When they co-exist, it is known as comorbid depression and anxiety.

Objective: To assess the prevalence and factors associated with comorbid depression and anxiety symptoms among older adults in western Nigeria.

Methods: This is a community-based, cross-sectional descriptive survey conducted among 328 consenting older adults. The Geriatric Depression Scale-Short Form (GDS-SF) and Generalized Anxiety Disorder-7 (GAD-7) questionnaires were administered to assess depressive and anxiety symptoms. Socio-demographic information was obtained using a separate questionnaire.

Results: The mean age of the participants was 70.1 years (SD = 9.2). Sixty per cent of the respondents were females and 58% were married.  The prevalence of comorbid depression and anxiety was 6.0% (2.4% in men and 6.6% in women) and 13% had depression-only while 19.9% had anxiety-only. Socio-demographic factors significantly associated with comorbid depression and anxiety included living alone (p = 0.001) and being not married (p = 0.028). However, only living alone (p = 0.015, OR = 1.79, 95% CI = 1.41- 25.36) independently predicted comorbid depression and anxiety symptoms among older adults.

Conclusion: Although the prevalence rates of “depression only” and “anxiety only” were higher among older adults, comorbid depression and anxiety was also prevalent in later life and living alone is a significant predictor. Therefore, there is a need to increase the recognition and treatment of comorbid depression and anxiety in older adults.
Giant Fibroadenoma in a Middle-Aged Woman Requiring Mastectomy: A Case Report
Authors: Nwashilli NJ , Obahiagbon I
Published: November 2020

Fibroadenomas are benign tumours of the breast. They are usually single, firm, rubbery masses, slow-growing and well encapsulated. Giant fibroadenomas are fibroadenomas at least 5cm in size or at least 500g in weight. The peculiarities of the index case include the massive size and weight of the breast, causing asymmetry and tissue distortion with little or no normal breast tissue on ultrasound scan. Also, such massive weight has not been reported in the literature as suggested by extensive search on databases such as Pubmed and Google Scholar. The main concern of the patient was the rapid growth over a year, with the attendant risk of malignancy. The mass was firm, lobulated, with a solitary axillary lymph node. An initial clinical diagnosis of phyllodes tumour was made. However, pre-operative Tru-cut biopsy histology suggested fibroadenoma and was confirmed using the excised post-operative specimen. Simple mastectomy with axillary lymph node excision was carried out. In conclusion, a large breast tumour may not be malignant. However, mastectomy may be a treatment option despite the benign nature of the tumour.
Diminished Health Returns of Own and Parental Education for Immigrants in the United States
Authors: Assari Shervin , Cuevas Adolfo
Published: November 2020

Background: Educational attainment is a strong social determinant of health. Marginalization-related Diminished Returns (MDRs), however, refer to smaller health effects of socioeconomic status, particularly educational attainment for marginalized groups compared to mainstream populations. While multiple studies have documented MDRs of educational attainment for racial, ethnic, and sexual minorities, there are no previous studies on MDRs of education among immigrants.Aims: To understand if the MDRs phenomenon also applies to immigrants, we compared immigrant and non-immigrant American adults for the effects of their own and parental educational attainment on subjective health.Methods: This study used a cross-sectional design and borrowed data from the General Social Survey (1972-2018). GSS is a series of nationally representative surveys in the U.S. Our analytical sample included 38,399 adults who were either non-immigrants (n = 34903; 90.9%) or immigrants (n = 3496; 9.1%). The main independent variables were own and parental educational attainment measured as four-level categorical variables. The dependent variable (DV) was poor subjective health, measured using a single item. Age, sex, marital status, and year of the survey were the covariates. Immigration status was the moderator.Results: Overall, individuals with higher educational attainment of own and parents reported better subjective health. We, however, found significant interactions between immigration status and both own and parental educational attainment on subjective health, which was suggestive of weaker protective effects of own and parental educational attainment against poor subjective health in immigrants than non-immigrant individuals.Conclusions: In the United States, immigrant adults experience poor subjective health disproportionate to their own and their parents educational attainment. That means we may observe worse than expected health of immigrants across all educational levels and social classes. Public policies should go beyond equal access to education by empowering marginalized people to leverage their education and secure better outcomes.
O tema das drogas na agenda internacional do Brasil: a definição de uma nova ameaça à segurança nacional na década de 1990
Authors: Villela Priscila
Published: November 2020

O tráfico de drogas vem ganhando destaque na agenda de segurança internacional desde a década de 1990. Neste período, o tema das drogas passou a ser tratado politicamente como uma ameaça ao sistema internacional, aos estados nacionais e aos indivíduos. A noção de “guerra às drogas” produzida nos Estados Unidos foi internacionalizada e incorporada pelo regime internacional de proibição da ONU, a partir a partir do qual se universalizou. Ela também pautou a presença dos EUA na América Latina, moldando as políticas de drogas desses países. A postura do Brasil com relação ao tema das drogas mudou significantemente nesse período, quando sua dimensão internacional passou a ganhar destaque na agenda política. Nessa esteira, uma série de aparatos legislativos e institucionais foram fortalecidos e instituídos com o objetivo de combater o tráfico de drogas, avaliado como uma ameaça à segurança internacional. O objetivo deste trabalho é compreender como o Brasil incorporou as ideias, diretrizes e políticas estabelecidas internacionalmente ao longo da década de 1990, identificando atores doméstico e internacionais, suas decisões e os mecanismos que permitiram a internalização de diretrizes estabelecidas internacionalmente em torno do problema das drogas.
Crimen organizado transnacional en América del Sur: un análisis de la presencia y gobernanza de actores armados no estatales en la frontera de Colombia y Venezuela
Authors: Pimenta Marília Carolina Barbosa de Souza , Rosero Luis Fernando Trejos
Published: November 2020

Este artigo tem como objetivo discutir o marco de segurança na subregião amazônica, localizada na parte sul da fronteira entre Colômbia e Venezuela, baseando-se em uma análise da presença de atores armados não estatais nos departamentos de Arauca, Vichada e Guainía. Tal análise nos permite refletir sobre os efeitos da baixa presença estatal nesta região, assim como sobre os mecanismos informais de governança gerados por tais grupos. Quanto aos padrões de cooperação entre tais atores, na dimensão temporal, caminha-se para alianças sem tempo definido, à medida que a operação continue lucrativa e bem-sucedida. Quanto ao tipo de cooperação, elas se apresentam como parcerias dentro de um mesmo tipo de atividade, como cadeia de produção, processamento e comercialização de drogas, extração de minérios ou extorsão. Por fim, o nível de cooperação permanece entre o pontual e o contínuo, porém com  presença de disputas, o que pode ser observado pelas explosões periódicas de violência como demonstração de força desses atores. As conclusões são que, em geral, os grupos dissidentes formados depois dos Acordos de Paz aumentaram na região, gerando ainda mais instabilidade, disputas e insegurança para as populações locais.
Guerra contra as drogas: medo e ódio e as opressões imbricadas de gênero, raça e classe em território brasileiro
Authors: Fernandes Luciana Costa
Published: November 2020

Em território latino-americano, a chamada “guerra contra as drogas” tem se apresentado como importante moduladora das relações de opressão que determinam hierarquias de raça, classe e gênero na região. Catalisadores de processos que remontam ao colonialismo, os delitos de drogas têm servido como legitimadores da manutenção de uma ordem de extermínio e encarceramento que atinge preferencialmente pessoas negras e, cada vez mais, mulheres. Através de revisão bibliográfica, este artigo pretende debater como a política está revolvida por constructos de ódio e medo próprios; constitui práticas de criminalização de pessoas negras e pobres em território marginal; bem como os impactos específicos no encarceramento de mulheres neste território.
Circulação de armas e a ausência de uma gestão integrada: uma análise de modelos de políticas públicas à luz do caso brasileiro
Authors: Silva Daniele Dionisio da
Published: November 2020

Esse artigo tem como proposta apresentar legislações e mecanismos de controle da circulação de armas pelo Brasil; e quais seriam os atores envolvidos, bem como demonstrar que há fragilidade de coletar e integrar dados em uma ferramenta de gestão integrada. Há ainda a proposta de se fazer uma confrontação de alguns mitos com as bases de dados coletadas e analisadas há mais de dez anos quando observamos um alinhamento único de fluxos políticos. Esse alinhamento pode ser ressaltado pelas pesquisas feitas pela ONG Viva Rio, em parceria com o Congresso apoiado pelo Ministério da Justiça, com a participação das Secretarias de Segurança Pública e observação das Nações Unidas. Ao longo do texto é ressaltada a necessidade do olhar sobre a micro e a macro geografia quando se pensam políticas públicas para circulação de armas. No caso brasileiro, observamos que alguns estados como Rio e São Paulo desenvolveram mecanismos próprios de coleta e análise de dados, sendo assim capazes de promover o aprimoramento de políticas. Ao fim do artigo é apresentada a circulação de armas pelo Brasil e sua dimensão transnacional, seguido de uma breve tentativa de aplicação de modelos teórico-conceituais de políticas públicas a temática.
Violações transnacionais: diplomacia, colaboração e repressão contra espanhóis (1936-1939)
Authors: Ribeiro Mariana Cardoso dos Santos
Published: November 2020

Neste artigo, analisaremos a participação da diplomacia espanhola nos atos de repressão praticados por autoridades varguistas contra espanhóis no Brasil, no período entre 1936 e 1939, e que levaram a violações de direitos humanos. Por meio da leitura crítica de correspondência trocada entre ex-funcionários do Ministério de Estado da Espanha, e que representavam o governo nacionalista no Brasil, e de relatórios e despachos produzidos pela polícia política do Estado de São Paulo (DEOPS/SP) avaliamos a eficácia da estratégia utilizada por diplomatas espanhóis para aniquilar seus inimigos. Sustentamos que as ações repressivas estiveram vinculadas intimamente à perseguição política que era empreendida na Espanha e foram cometidas em conjunto – por agentes públicos brasileiros e espanhóis - transpondo, assim, as fronteiras espanholas para atingir cidadãos deste país no território brasileiro.
Esittelyssä Suomen tietokirjailijat ry
Authors: Rutanen Anne
Published: November 2020

Tietokirjallisuuden tekijöitä Suomessa edustaa Suomen tietokirjailijat ry, joka on maamme suurin kirjailijajärjestö. Yhdistys edistää tietokirjallisuutta ja valvoo tieto- ja oppikirjailijoiden tekijänoikeudellisia ja taloudellisia etuja. Yhdistys perustettiin vuonna 1983, kun tietokirjailijoita ja oppikirjailijoita edustavat järjestöt yhdistyivät, ja se on kasvanut siitä tasaisesti näihin päiviin asti. Yhdistys edustaa nykyään 3200 tekijää, ja yhdistyksen jäsenet ovat muun muassa yleisten tietokirjojen, oppimateriaalien, oppaiden, sanakirjojen ja tietokirja-artikkeleiden kirjoittajia.
الإفتاء بالتيسير للأقليات المسلمة في الأحوال الشخصية
Authors: Haq Husnul
Published: November 2020

The muslim minorities in non-muslim countries face many problems. The most important of which are religious problems. They want to deal with non-muslims, without taking away their islamic personality. They are in dire need of a fatwa that is easy and tolerant, away from narrowing and embarrassment. Contemporary scholars, especially syekh yusuf qaradhawi, respond this need, and issue fatwas, which are easy and tolerant. The research aims to clarify the principle of facilitation in the fatwas of contemporary scholars with regard to muslim minorities in the field of personal status, and the suitability of this principle to the principle of facilitation in islamic jurisprudence. The character of the research is a descriptive, analytical, and critical. The researcher concludes that the scholars adhered to the principle of facilitation in their fatwas for muslim minorities, in the field of personal status. And the best testimony to that is the fact that they have stated that it is permissible for a woman to remain with her non-muslim husband, and that they are allowed to legalize the inheritance of a non-muslim. The facilitation adopted by them is commensurate with the facilitation of islamic jurisprudence, its principles and purposes, because it stands on the principle of taking into account of necessity, need, license, rule of origin, and changing the ruling by changing its cause.
Uma fera sempre à espreita – o que é fantasia em Freud
Authors: Manzi Ronaldo
Published: November 2020

Minha primeira tese nesse livro é que Freud parte da concepção de verdade enquanto verificação e posteriormente vai desenvolvendo outras possibilidades de se pensar a verdade, sem que essas concepções se excluam ou se anulem. A questão da fantasia é fundamental nesse processo de pensamento. Acrescenta-se a isso que a fantasia envolve também o problema da memória. Afinal, o que estamos ouvindo quando alguém conta sobre sua vida? Uma estória que pode ser confirmada? Uma verdade? – algo que corresponde com o que “realmente” aconteceu? Ver-se-á que Freud irá propor, diante da impossibilidade de afirmarmos uma suposta confirmação com a realidade, que há uma realidade psíquica. Estamos diante de uma construção psíquica em que a pessoa nos conta algo que é uma realidade para ela, mesmo que não tenha nenhuma conexão ao que supostamente aconteceu. O livro pretende desdobrar a concepção de fantasia na obra de Freud.
Integrasi Pendidikan Berbasis Lingkungan dengan Nilai-nilai Islam: Upaya Meningkatkan Etika dan Literasi lingkungan
Authors: Idris Muh. , Mokodenseho Sabil , Willya Evra , Otta Yusno Abdullah
Published: November 2020

Educating students through a learning process is not only aimed to enable them to obtain knowledge and skill in various things but also, ethical formation is an essential part of the education objective itself. Knowledge, expertise, and ethics can be achieved through problem-based learning with a socio-scientific context integrated with Islamic values. Problem-solving with socio-context issues has strengthened students' engagement in environmental issues, and their involvement is finally able to improve their understanding of environmental problems. Islamic values which integrated with knowledge are believed to influence students' mindset and perception. Ethics and sensitivity to the environment begin with the way they view and act on the environment. An effective environmental educational concept can strengthen environmental literacy and readiness to behave well concerning the environment. Problem-based learning is learning using the problem as a starting point for learning. This learning has directed students to seek and determine relevant sources with knowledge. Therefore, this learning challenges students to build knowledge independently.
Outbreak of strains of SARS CoV-2, its prevalence & preventive measures taken by different Countries
Authors: Yadav Manoj Kumar , Vibhuti Arpana , Priyadarshini Anjali , Gupta Archana , Raj V. Samuel , Pandey ramendra Pati
Published: November 2020

World Health Organization (WHO) announced the official name of the 2019 novel coronavirus associated diseases coronavirus disease (COVID-19) and the reference name for the virus is severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).Transmission of SARS CoV-2 in humans occurs mainly via respiratory droplet or aerosols, close contact with an infected person, exposed to coughing, sneezing and likely in oral-faecal. The COVID-19 outbreak started in different countries at different times, and now those countries are at different stages. By comparing infection trajectories from the 100th case mark, we have been able to observe the rapid spread of the virus in various countries. To date, no specific antiviral drugs or vaccines are available for the control of SARS CoV-2. The experts at global level suggest implementation of strict measures such as practicing quarantine, social distancing, avoiding social gathering to reduce the number of COVID-19 cases. This is a dynamically unfolding pandemic that will require the concerted efforts of counties around the world to control. Given the unfold of the new coronavirus and its impacts on human health, it becomes pertinent to device methods for handling this public health emergency at the community, national, and international levels. it's vital to additional investigate a preventative intervention to halt the unfold of the COVID-19 infection, because it has been discovered that not all countries have constant fate concerning infection and fatality. It becomes vital to acknowledge and study the factors accountable and also the underlying mechanisms for this.
Dosa dosa besar
Authors: Mufakir Abdul
Published: November 2020

Dosa adalah segala perbuatan yang bertentangan dengan kehendak dan perintahAllah SWT. Sampai disini belum dibedakan besar kecilnya dosa. Abdullah binAbbas berkata,“ Setiap perbuatan menentang ajaran Islam adalah dosa besar.”,kelalaian dan kekhilapan yang dilakukan manusia ini dapat dianggab sebagaidosa-dosa kecil, namun dosa-dosa kecil ini bila terus-menerus dilakukan makaakan menjadi dosa besar. Tulisan ini mencoba mengungkap serba sedikittentang perbuatan dosa yang sering dilakukan manusia serta dilihat dimensipsikologis yang terkandung dalam perbuatan dosa tersebut sehingga dampak apasaja yang terjadi bagi pelaku dosa. Diawali dari defenisi dosa, macam-macamdosa, deminsi psikologis yang terkandung dalam perbuatan dosa, serta efekpsikologis perbuatan dosa pada kehidupan seseorang.