bluuebunny/crossref_metadata_2025 huggingface dataset:
Literasi Etika Digital Komunitas Maya pada Masa Pandemi Covid-19
Authors: Farhan Muhammad , Nashier Luthfi Abdurahman , Jaelani Jaka Muhammad , Kahfi Mochammad , Yusuf Alifa Witri Alfahira , Aflaah Gina Ramadhantie , Azhari Sonia Nada Nur , Hazar Aura Fitria , Nuraeni Fitri
Published: October 2022

Masa pandemi Covid-19 yang tak kunjung usai menjadi sebuah ketidakpastian sendiri bagi masyarakat, ditambah dengan keresahan dari banyaknya hoax mengenai pandemi covid-19 yang bertebaran diberbagai media semakin memperburuk keadaan. Literasi etika digital merupakan salah satu bentuk upaya untuk menghadapi hoax di masa pandemi ini. Untuk itu, kegiatan Kuliah Kerja Nyata (KKN) Tematik dengan tema pengabdian pada komunitas maya menjadi sarana untuk meningkatkan literasi masyarakat dalam beretika digital, seperti bagaimana cara mengenali, mencegah penyebaran dan mengatasi berita hoax yang sudah tersebar di lingkungannya. Metode yang dilakukan dengan cara mengukur pengetahuan komunitas maya melalui penyuluhan etika digital yang diawali oleh Pre-test, penyampaian materi, kemudian Post-test. Dengan ini diharapkan masyarakat dapat lebih berhati-hati dalam menerima dan menyebarkan berita pada
Pengabdian Kepada Komunitas Maya Terkait Ketekniksipilan Melalui Sajian Webinar
Authors: Mulyana Subhan , Putri Arin Febriani , Prayogi Depi , Chalid Nugi Abdul , Isnayanti Isna Nur , Zedi Ardhiya Rachmala , Ilham Ilham , Priatna Risris Rusyana , Firmansyah Muhammad Rafli , Kholiq Andri Muhammad , Ali Khoirul Mufti , Nugraha Muhammad Adam
Published: October 2022

Kuliah Kerja Nyata (KKN) pada masa pandemi covid-19 ini tentu sangat berbeda dengan KKN sebelumnya. Pada masa pandemi covid-19 ini kita tidak bisa langsung bertemu dengan masyarakat untuk melaksanakan KKN. KKN kali ini bisa dilaksanakan secara langsung dengan tetap menjalankan protokol kesehatan secara ketat dan bisa dilaksanakan secara daring, contohnya dengan mengadakan webinar. Webinar ini bertujuan untuk menyalurkan ilmu-ilmu yang sudah dipelajari sebagai bentuk pengabdian kepada masyarakat. Salah satu contoh KKN daring ini adalah webinar yang diselenggarakan oleh kelompok 4 KKN Teknik Sipil. Webinar yang dilaksanakan oleh kelompok 4 ini terbagi menjadi 4 webinar dengan masing-masing webinar memiliki judul yang berbeda-beda. Hasil dari webinar ini menunjukkan bahwa kegiatan KKN sebagai wujud pengabdian kepada masyarakat pada masa pandemi covid-19 ini masih bisa dirasakan manfaatnya oleh masyarakat dan peran Mahasiswa masih bisa dilakukan dengan rangkaian program atau kegiatan inovatif serta tetap menjalankan protokol kesehatan untuk mencegah penyebaran wabah covid-19. Metode yang digunakan tentunya secara daring, dikarenakan kita berorientasi kepada situasi yang sedang terjadi di masa pandemic seperti ini, adapun yang dilaksanakan secara luring seperti untuk sosialisasi, tetapi tetap dengan menggunakan protokol kesehatan.
Efektivitas Media Sosial untuk Meningkatkan Penjualan Saat Pemberlakuan Pembatasan Kegiatan Masyarakat
Authors: Ramdani Fachmi , Alijoyo Antonius
Published: October 2022

Kebijakan Pemberlakuan Pembatasan Kegiatan Masyarakat (PPKM) merupakan cerminan kesiap-siagaan Pemerintah Indonesia untuk mengurangi penyebaran Virus Covid-19. Disisi lain kebijakan permbatasan kegiatan masyarat tersebut mempengaruhi para pelaku usaha dalam kegiatan penjualannya, karena masyarakat diharuskan lebih banyak kegiatannya didalam rumah (Work From Home). Perkembangan teknologi informasi yang sangat pesat di Indonesia mempengaruhi kebiasaan masyarat dalam berinteraksi sosial. Media sosial merupakan salah satu cara yang bisa dilakukan oleh para pelaku usaha dalam meningkatkan penjualan dimasa pembatasan kegiatan masyarakat ini. Dalam penelitian ini dilakukan secara deskriptif kualitatif dengan teknik pengumpulan data observasi. Kesimpulan dari hasil penelitian ini dapat disimpulkan bahwa para pelaku usaha mampu beradaptasi dengan perkembangan teknologi informasi dengan memanfaatkan fitur yang tersedia di media sosial untuk meningkatkan penjualan di masa Pemberlakuan Pembatasan Kegiatan Masyarakat (PPKM).
Finansal Astroloji: Merkür Retrosu Finansal Piyasaları Etkiler Mi?
Authors: KONAK Fatih , ÖZKAHVECİ Esra
Published: October 2022

Piyasa fiyatlarının rassal meydana geldiğini ve önceden belirlenen trendlerin finansal enstrümanların fiyatlarını tahminlemede yetersiz kaldığını savunan Etkin Piyasalar Hipotezi, E. Fama tarafından ileri sürülen geleneksel bir teoridir. Diğer taraftan, piyasa fiyatlarının çeşitli olay ve durumdan etkilendiğini ve bireyin çeşitli yöntemler aracılığıyla bazı günlerde anormal getiri elde etme imkanına sahip olduğunu savunan davranışsal finans yaklaşımı ise, Etkin Piyasalar Hipotezi ile aynı paydada buluşmamaktadır. Yatırımcıyı irrasyonel olarak ele alan davranışsal finans, yatırımcının özel bir gün, ay, olay ve hatta astroloji olaylarından etkilendiğini ve bu gibi durumların beklenen getiri düzeyinde sapmalara neden olabileceğini savunmaktadır. Bu kapsamda çalışmada, 02.01.2008-02.12.2021 döneminde meydana gelen Merkür Retro’sunun BRICS ve Türkiye’ye ait gösterge endeksleri üzerine olası etkisi incelenmiştir. Amaç doğrultusunda, belirlenen dönemde Merkür Retro’sunun oluştuğu 672 güne ait veriler EGARCH modeli ile analiz edilmiş ve elde edilen analiz bulguları neticesinde, belirlenen dönemlerde Merkür Retro’sunun Çin ve Güney Afrika gösterge Endeksleri üzerinde pozitif, Türkiye, Brezilya, Rusya ve Hindistan gösterge Endeksleri üzerinde ise istatistiksel olarak anlamlılık içermeyen negatif etkisi olduğu görülmüştür. Bu doğrultuda, BRICS ve BIST 100 Endeksi’nin zayıf formda etkin bir piyasa olduğu ve Merkür Retrosu’nun bu endeksler için bir anomali olmadığı tespit edilmiştir.
Kurumsal Körlüğün Çalışanlar Üzerindeki Etkisi: Bir Alan Araştırması
Authors: ÖZBAĞIŞ Ayşegül
Published: October 2022

Bu araştırmanın amacı, kurumsal körlük ve boyutlarının (bireysel, kurumsal, sektörel ve yapılan işin rutinlik boyutu) çalışan tutumu, iş tatmini ve iş performansı üzerindeki etkisi çalışan tutumunun ise iş tatmini ve iş performansı üzerindeki etkisini incelemektir. Araştırmanın örneklemini Kahramanmaraş Büyükşehir Belediyesi, Onikişubat Belediyesi ve Dulkadiroğlu Belediyesi’nin 473 çalışanı meydana getirmektedir. Araştırma verilerini toplamak için anket yönteminden faydalanılmıştır. Araştırma verileri SPSS 25.0 programında frekans analizi, güvenirlik analizi, korelasyon analizi ve regresyon analiziyle test edilmiştir. Yapılan regresyon analizi sonuçlarına göre; kurumsal körlük boyutlarından olan bireysel boyut ve yapılan işin rutinlik boyutunun çalışan tutumunu etkilemediği ancak kurumsal ve sektörel boyutun çalışan tutumunu pozitif yönde etkilediği belirlenmiştir. Yine bireysel boyutun iş tatmini ve iş performansını negatif yönde etkilediği; kurumsal, sektörel ve yapılan işin rutinlik boyutunun iş performansını pozitif yönde etkilediği sonucuna ulaşılmıştır. Diğer taraftan kurumsal ve sektörel boyutun iş tatminini pozitif yönde etkilediği belirlenirken yapılan işin rutinlik boyutunun iş tatminini etkilemediği tespit edilmiştir. Çalışan tutumunun ise iş tatmini ve iş performansını pozitif yönde etkilediği tespit edilmiştir. Sonuçlar teorik ve uygulama kapsamında tartışılmıştır.
IN THE COVID 19 PANDEMIC DETERMINING THE CHANGE IN THE DEBT STRUCTURE OF BUSINESSES
Authors: SAĞLAR Jale
Published: October 2022

With the Covid 19 pandemic, measures have been taken to prevent the rapid spread of the virus in Turkey and have been implemented quickly. While restrictions were imposed on the activities of businesses in some sectors, the majority of business activities were moved to the electronic environment. The main purpose of this study; It is to determine the change in the borrowing structures of businesses during the times of the Covid 19 pandemic. It will be an important data in the decisions to be taken for these enterprises and in economic evaluations. In this direction, within the scope of the study, an examination was made on the manufacturing companies traded in Borsa Istanbul and whose financial statements were announced on the Public Disclosure Platform. The financial data of the companies included in the research were analyzed with the ratio analysis technique. Financial structure ratios, one of the ratio groups in the ratio analysis technique, are the ratios that explain the resource structure of the enterprises, in other words, the debt-equity balance. In the study, the financial structure ratios of the times when the Covid 19 pandemic was intense and the financial structure ratios of previous years were compared. In the comparison, positive and negative changes in the ratios were determined and the number of affected companies was calculated for positive or negative changes
Elektrikli Araç Satın Alma Niyetini Hangi Faktörler Etkiler? Bir Tüketici Araştırması
Authors: KOCAGÖZ Elif , İĞDE Çağrı Selman
Published: October 2022

Artan çevresel kaygılar ve gelişen teknoloji ile birlikte son dönemlerde elektrikli araçlara olan ilgi düzeyi artmıştır. Pazar payı giderek artan ve geleceğin ulaşım ekosisteminde önemli bir yeri olacağı öngörülen bu araçlarla ilgili yapılacak olan tüketici araştırmaları da önem kazanmaktadır. Çalışmanın amacı Türkiye’deki tüketicilerin elektrikli araç satın alma niyetini; elektrikli araçlara yönelik değerlendirmeler, algılanan fiyat değeri ve çevresel kaygı bağlamında incelemektir. Çalışma ile tüketicilerin elektrikli araçları satın alma niyetlerini etkileyen faktörleri ve bu faktörlerin önem derecelerini belirlemek suretiyle hem uygulamacılara hem de ilgili literatüre katkı sağlamak planlanmaktadır. Çalışma kapsamında kolayda örnekleme yöntemi ile ulaşılan 323 kişiye çevrim içi olarak anket uygulanmıştır. Korelasyon ve regresyon analizleri ile birlikte; ilave olarak -satın alma niyetinin bazı gruplar arasında anlamlı farklılaşıp farklılaşmadığına yönelik- t-testi ve ANOVA yapılmıştır. Sonuç olarak, tüketicilerin elektrikli araçlara yönelik değerlendirmelerinin, algıladıkları fiyat değerinin ve çevresel kaygılarının elektrikli araç satın alma niyetini pozitif yönde istatistiksel olarak anlamlı etkilediği görülmüştür. Ayrıca katılımcıların satın alma niyetlerinin bazı seçili değişkenler açısından gruplar arasında anlamlı olarak farklılaştığı bulunmuştur.
Türkiye ve Avrupa Birliği ülkelerinin Paris İklim Anlaşmasına Duyarlılığı ve Yeşil Lojistiğin Uygulanabilirliğinin Sınanması
Authors: KESGİNGÖZ Hayrettin , MATYAR TANIR Yağmur
Published: October 2022

Tedarik zincirinin bir parçası olan lojistik, tedarik zincirinin daha yeşil hale gelmesiyle yeşil lojistik kavramının ortaya çıkmasını sağlamış ve çevre sorunlarının tüm dünyada ciddi bir hale gelmesiyle çevreci uygulamaların önemini arttırmıştır. Ayrıca çevre sorunlarına duyarlı bir şekilde tedarik zincirinin lojistik uygulamalarının sürdürülebilirliği için de yeşil lojistik önem arz etmektedir. Ülkeler için lojistik sektörünün önemi her yıl daha da artmaktadır ve ülkelerin sektöründeki performanslarının değerlendirilmesi için Lojistik Performans Endeksi(LPI)’ne bakmak gerekir. Her iki senede bir Dünya Bankası’nın yayınladığı LPI listelerinde ülkeler lojistik sektöründeki sıralamalarını görmektedir. 2015’te imzalanan Paris İklim Anlaşması’nın temel amaçlarından biri olan sera gazı emisyonunun sıfıra indirilerek yenilenebilir enerji kaynaklarının yoğun olarak kullanıldığı, çevreci uygulamaların ön planda olduğu bir dünya için ülkeler iklim anlaşmasını kabul etmişlerdir. Bu anlaşma ile sera gazı emisyonlarının düşük seviyelere getirilmesi amaçlanmaktadır. Sera gazı emisyonu lojistik sektörünün en önemli çıktısıdır. Bu çıktı seviyelerinin azaltılması için yeşil lojistik uygulamalarına yer verilmelidir. Bu çalışmada 2007, 2010, 2012, 2014, 2016, 2018 yıllarında yeşil lojistik uygulamaları kapsamında Lojistik Performans Endeksi raporu ve AB Üye Ülkelerinin kişi başına düşen sera gazı emisyonları endeksleri karşılaştırılmıştır. Böylelikle Türkiye’nin ve AB ülkelerinin İklim Anlaşmasına duyarlılığı karşılaştırılmıştır. Bu karşılaştırma ile Türkiye ve Avrupa Birliği ülkelerinin LPI değerleri ve sera gazı emisyonları arasında ileri ve geriye doğru bağlantılar tespit edilmiştir. Bu bağlantı kapsamında sera gazı emisyonu değerleri ve LPI değerlerinin eş anlı bir şekilde hareket ettiği görülmüştür. Bu eş anlı hareket yeşil lojistik lehine atılması gereken adımların gerekliliğini ortaya koymuştur.
Unlocking the Potential of Immuno-Oncology in Advanced Cutaneous Squamous Cell Carcinoma: Role of Checkpoint Blockade
Authors: Pedder Alan
Published: October 2022

Dr Robert welcomed the delegates to the symposium and outlined the agenda for the meeting, before presenting the first session on understanding cutaneous squamous cell carcinoma (CSCC). The rising incidence of CSCC presents a major challenge for healthcare systems and the frequency and impact of progression to advanced disease is underestimated. The diverse range and potential complications of CSCC lesions require a multidisciplinary approach, in which dermatologists play an important role. The message that CSCC remains a disease of high unmet need was echoed by Dr Peris, who presented on existing treatment approaches for the management of advanced CSCC. In the absence of an established management pathway for patients with locally advanced or metastatic disease, clinicians must rely on limited or anecdotal evidence to inform treatment decisions. Conventional chemotherapy and targeted therapies produce variable responses that are often short-lived, demonstrating a need for more effective and tolerable systemic treatments. Guidelines recognise these limitations and do not make any firm recommendations for the treatment of advanced CSCC. The importance of a multidisciplinary approach was underlined by Dr Migden’s presentation on future novel therapeutic strategies in CSCC. Immunotherapy is an exciting frontier that is becoming increasingly relevant to many specialists, including dermatologists, with several ongoing trials of immune checkpoint inhibitors in patients with advanced CSCC. A strong rationale exists for immunotherapy in these patients and the current evidence base supports the use of immune checkpoint blockade as an alternative to cytotoxic chemotherapy and targeted agents. Dr Migden concluded the symposium with an interactive presentation of five case studies of successful checkpoint inhibitor treatment of locally advanced CSCC, emphasising the key role of dermatologists in a multidisciplinary team approach.
Dimethyl Fumarate in Psoriasis Therapy
Authors: Fricker Janet
Published: October 2022

This presentation by Dr Weisenseel considered the role of fumaric acid esters (FAE) in plaque psoriasis. FAE, first developed in 1959 and approved in 1994, are available in two forms: dimethyl fumarate (DMF) alone (e.g. Skilarence®; Almirall Ltd., Uxbridge, UK) or DMF together with calcium, zinc, and magnesium salts of monoethyl fumarate (Fumaderm®). Up-titration is recommended for FAE/DMF dosing. The BRIDGE study demonstrated that Skilarence has comparable efficacy, safety, and tolerability to Fumaderm, while the retrospective FUTURE study demonstrated that the efficacy of FAE increase over time. Additionally, in separate studies combining FAE with ultraviolet therapy, FAE were shown to achieve a faster clinical response and required a lower mean maximum daily dose in the up-titration period. FAE side effects, such as flushing and gastrointestinal effects, can usually be handled by individualising patient doses, involving both up and down-titration. Dr Weisenseel explained how patients are required to have their lymphocyte levels monitored every 3 months, with lymphocyte counts <700 cells/µL in two consecutive tests considered the criterion for stopping DMF therapy due to the increased risk of progressive multifocal leukoencephalopathy (PML). There is no evidence of drug-drug interactions with FAE, although retinoids, cyclosporin, immune suppressants, and cytostatics should be avoided.
IL-23 Inhibition in Psoriasis: Changing the Present, Shaping the Future
Authors: Scutt Paul
Published: October 2022

This symposium took place at the 27th European Academy of Dermatology and Venereology (EADV) Congress. The session examined the latest data for contemporary therapeutic agents in psoriasis, focussing on IL-23 inhibitors as the most recently approved class of therapies, and provided perspectives on the implications of these data for clinical practice. With a wide array of potential treatment options now available for psoriasis, the symposium initially explored remaining areas of unmet treatment need, highlighting correct and timely diagnosis, effective management of comorbidities, undertreatment, and real-world data as key aspects requiring further improvement. The speakers subsequently reviewed the current evidence for the latest therapeutic strategies in psoriasis, concentrating on the therapeutic attributes that are considered most desirable for an ‘ideal’ agent, including efficacy for psoriasis and related comorbidities, durability of effect, improvement in quality of life, safety, and convenience. In this context, the rationale for selective IL-23 inhibition was examined, with the faculty highlighting how this approach differs from IL-17 inhibitors, at both the mechanistic and clinical levels. In addition, the session called attention to areas of ongoing investigation where there may be opportunities for the latest therapies to provide further patient benefit, with focus on the potential for novel, less frequent dosing intervals with IL-23 inhibitors.
IL-23 Inhibition as a Key Component in Psoriasis Treatment is Here to Stay
Authors: Fricker Janet
Published: October 2022

Prof Elke de Jong focussed her presentation on data from randomised clinical trials (RCT) and real-world evidence (RWE) from psoriasis patient registries. Such data is complementary with RCT having high internal validity but low external validity, and RWE having low internal validity but high external validity. She reviewed the predictors for stopping psoriasis biological treatment of high BMI and female sex and predictors for continuing treatment as concurrent psoriatic arthritis.

Current unmet needs in psoriasis that demonstrate the requirement for additional treatments include patients experiencing psoriasis for roughly 20 years before being prescribed biologics, prevention of damage (e.g., psoriatic arthritis), achieving sustained effectiveness or cure, developing better patient-reported outcome measures, and better treatment of specific psoriatic areas (scalp, face, nails, and genitalia).

Dr Andreas Pinter reviewed the role played by IL-23, IL-17A, and IL-22 in psoriasis, and new agents including ustekinumab blocking both IL-12 and IL-23; guselkumab, tildrakizumab, and risankizumab blocking IL-23; and brodalumab blocking IL-17A.

He explored VOYAGE 1 data that showed that the IL-23 inhibitor guselkumab maintained Psoriasis Area and Severity Index (PASI) 90 response through Week 156 in >80% of patients. Furthermore, VOYAGE 2 results showed PASI 90 response was maintained in >50% of patients 6 months after guselkumab withdrawal.

He demonstrated how re-treatment with guselkumab led to a high PASI 90 response in patients who lost PASI 90 response after withdrawal of treatment. Data from the VOYAGE 1 study further showed that guselkumab produced statistically significant improvements in scalp and palmar plantar scores over adalimumab, and comparable nail scores to adalimumab.

Data from the UltlMMa-1 and ULtlMMa-2 studies showed that IL-23 inhibition with risankizumab produced better quality of life scores than with ustekinumab. Additionally, the ECLIPSE trial showed that IL-23 inhibition with guselkumab produced higher PASI 90 response rates than IL-17 inhibition with secukinumab at Week 48.
Is Complete Skin Clearance in Psoriasis the Answer?
Authors: Saul Helen
Published: October 2022

Prof Reich outlined the new understanding of psoriasis pathogenesis, with IL-23 rather than IL-12 considered the pivotal cytokine pathway. This understanding, along with new therapeutic agents, suggests that complete clearance is becoming a realistic treatment goal for patients.

Prof Iversen gave a detailed description of the pathogenesis of psoriasis. Psoriasis was previously thought to be driven by Th1 cells, but the key driver is now believed to be the IL-23/Th17 pathway. In a newly understood intermediate step, immature T cells develop into either inducible or regulatory T cells; the inducible Th17 cells mature into either pathogenic or non-pathogenic T cells, differentiation is dependent on IL-23 levels. Prof Iversen described findings that suggest IL-12 may have anti-inflammatory properties. This cytokine model may explain the different effects of drugs that target IL-12 and IL-23 versus those that target IL-23 alone.

Prof Reich and Prof Bachelez presented key clinical data on new IL-23-targeted therapeutic agents. The VOYAGE 1 study with guselkumab found Psoriasis Area Severity Index (PASI) 90 rates of 81.1% at Week 100 and PASI 100 rates >49.0%.1 The reSURFACE trials with tildrakizumab demonstrated lower PASI 90 and PASI 100 response rates than VOYAGE 1, but, again, responses were durable and the agent was well-tolerated.2 UltIMMa 1 and 2 were replicate studies that compared the IL-23 inhibitor risankizumab with the IL-12 and IL-23 inhibitor ustekinumab. At Week 52, PASI 90 response rates were 82% for risankizumab, 78% in the group switched to risankizumab after placebo, and 44% for those on ustekinumab.3 This suggested that blocking IL-23 alone is superior to blocking both IL-12 and IL-23. The response to risankizumab was stable and durable; the safety profile was comparable to the comparator ustekinumab. IMMvent4 and IMMhance5 demonstrated robustness of response to risankizumab among patients who had failed prior therapies. The speakers and the audience concluded that these early trials suggest that the IL-23 inhibitors are an attractive new class of agents for the treatment of psoriasis.
SINERGI DAN KOLABORASI SEBAGAI STRATEGI MEDIA CETAK BERTAHAN DALAM ERA DISRUPSI
Authors: Dewi Danar Kristiana
Published: October 2022

Survai yang dilakukan oleh Nielsen pada tahun 2017, menyimpulkan media cetak masih bisa mempertahankan posisinya meskipun penetrasi pembaca diakui menurun. Sebagai industri informasi media cetak melakukan berbagai upaya penyegaran dalam menghadapi disrupsi dan era digital. Salah satu strategi bertahan yang dilakukan oleh media cetak adalah sinergi dan kolaborasi. Metode ini tepat dilaksanakan oleh media, mengingat pada era ini kolaborasi adalah hal yang palling mungkin dilakukan untuk menghadapi tantangan era digital yang serba cepat. Industri media, tidak bisa berjalan sendiri tanpa melakukan transformasi, sinergi dan kolaborasi dilakukan untuk mengimbagi gerak digital yang sangat massif. Penelitian ini merupakan penelitian kualitatif dengan objek penelitian media cetak yang berada di Kota Surakarta. Dari hasil penelitian yang dilakukan ditemukan bahwa untuk menghadapi era disrupsi, media cetak melakukan kolaborasi dan sinergi dengan berbagai mitra dalam menjalankan proses bisnisnya. Ciri khas digital juga dapat ditemui dalam media cetak lokal, yang saat ini telah menghapus sekat dan Batasan wilayah untuk berkembang baik dalam skala regional, nasional dan global.Keyword : media cetak, kolaborasi, sinergi disrupsi
Perencanaan Komunikasi Politik Ali Ibrahim Dalam Pemilihan Kepala Daerah Tidore Kepulauan
Authors: Amir Saiful , El Adawiyah Sa’diyah
Published: October 2022

Komunikasi politik merupakan bagian penting dari setiap aktivitas politik dalam kegiatan Pilkada. Komunikasi politik dipilih sebagai strategi untuk mempengaruhi khalayak karena memiliki keunggulan iklan politik. Tujuan penelitian ini adalah untuk mengetahui perencanaan komunikasi politik Ali Ibrahim  dalam Pemilihan Kepala Daerah Tidore Kepulauan 2020 dengan delapan indikator perencanaan komunikasi politik diantaranya analisis masalah, analisis khalayak, perumusan tujuan, pemilihan media, pengembangan pesan, perencanaan produksi media, perencanaan manajemen program, serta monitoring dan evaluasi. Penelitian ini menggunakan pendekatan kualitatif dengan metode studi kasus yang dijabarkan secara deskriptif. Teknik pengumpulan data dengan wawancara dan dokumentasi. Analisis data dilakukan berupa reduksi data, penyajian data dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa komunikasi politik Ali Ibrahim dalam Pilkada Tidore Kepulauan 2020 yaitu menganalisis khalayak dengan tidak membedakan status sosialnya, analisis khalayak digunakan untuk mengetahui segmentasi dan penggunaan gaya komunikasi Ali Ibrahim, kemudian merumuskan tujuan dalam pelaksanaan komunikasi poltik untuk menentukan media. Kekuatan media menjangkau dan menyebarluaskan khalayak dalam skala besar merupakan kontributor keberhasilan komunikasi politik. Pesan dibangun dan dikemas sesuai dengan khalayak yang dituju serta dikemas dan diproduksi dalam berbagai bentuk pada media masa, media sosial, dan media luar dengan perencanaan pengelolaan program yang baik serta melakukan monitoring dan evaluasi.
FENOMENA PAWANG HUJAN (ANALISIS RESEPSI MAHASISWA MAGISTER ILMU KOMUNIKASI UNIVERSITAS ISLAM BANDUNG TERHADAP PAWANG HUJAN MANDALIKA DALAM VIDEO BERJUDUL "MENDEBAT SI PAWANG HUJAN" PADA PODCAST DEDDY CORBUZIER)
Authors: Sari Mira Kumala
Published: October 2022

Sosok pawang hujan bernama Rara yang hadir di tengah perhelatan dunia ajang Motor GP di Mandalika menjadi perhatian publik, tidak hanya Indonesia, bahkan dunia. Sang Pawang menjadi kabar yang fenomenal, menjadi perbincangan publik di media, menggeser popularitas para pembalap kawakan di ajang Motor GP Mandalika. Fenomena Pawang Hujan di Mandalika, di luar dugaan, bahkan boleh jadi tidak masuk rencana agenda pemberitaan. Namun bagi media, hal yang tak disangka dan tak diduga ini berdampak terhadap nilai pemberitaan dan menyedot perhatian. Beragam penerimaan dalam bentuk respon dan persepsi khalayak terhadap fenomena pawang hujan ini bermunculan lewat berbagai komentar. Khalayak bukan lagi partisipan yang pasif yang hanya menonton sebagaimana menonton televisi sebagai media komunikasi satu arah akan tetapi mampu mekonstruksi dan merekonstruksi makna yang ada dalam sebuah tayangan media. Posisi-posisi khalayak dikategorikan berdasarkan teori Encoding/Decoding milik Stuart Hall dalam tiga posisi pembacaan audiens yakni Dominant position, Negotiated position dan Oppositional position. Hasil penelitian menunjukkan bahwa pemaknaan audiens terhadap pernyataan Rara sang pawang hujan dalam video “Mendebat Si Pawang Hujan" pada podcast Deddy Corbuzier terhadap ketiga informan menghasilkan pemaknaan yang didominasi oleh posisi Oppositional Position.
PERSEPSI FOLLOWERS TERHADAP POSTINGAN KEPUTUSAN LEPAS HIJAB INFLUENCER @RACHELVENYA DI INSTAGRAM
Authors: Afifa Anisatul , Kusnarto Kusnarto
Published: October 2022

Penelitian ini bertujuan untuk mengetahui bagaimana Persepsi followers terhadap postingan keputusan lepas hijab influencer @rachelvennya di instagram. Metode yang digunakan dalam penelitian ini adalah metode deskriptif kualitatif yang bertujuan untuk menjelaskan fenomena tertentu dengan secara jelas dan terperinci. Teori yang digunakan dalam penelitian ini yaitu teori perbedaan individual (individual differences theory) dan pada penelitian ini teknik pengumpulan data yang digunakan adalah dengan cara wawancara. Hasil penelitian ini menunjukkan bahwa terdapat dua perbedaan pandangan dari followers terhadap postingan tersebut, yaitu terdapat followers dengan sudut pandang lebih menyayangkan dan menghargai dengan persepsi yang positif serta followers yang lainnya memiliki sudut pandang yang negatif dengan kecewa dan lost respect terhadap influencer Rachel Vennya.
STRATEGI KOMUNIKASI HUMAS KPCPEN DALAM MENINGKATKAN KEPERCAYAAN DI INDONESIA
Authors: Kinanti Krizia Putri , Hardiyanti Siti Tanti
Published: October 2022

Penelitian ini memiliki tujuan untuk menganalisis dan memahami apa strategi komunikasi yang digunakan humas dalam meningkatkan public trust masyarakat terhadap Komite Penanganan Covid-19 dan Pemulihan Ekonomi Nasional (KPCPEN). Public trust adalah simpulan dari kegiatan komunikasi humas, sangat menarik untuk diteliti, mengingat public trust akan terbangun dengan baik apabila humas memiliki strategi yang tepat guna di dalam melaksanakan kegiatan komunikasinya. Penelitian ini menggunakan pendekatan kualitatif jenis studi kasus. Informan dalam penelitian ini terdiri dari humas KPCPEN. Teknik pengumpulan data dilakukan melalui interview, observasi dan dokumentasi. Analisis datanya dilakukan secara sirkuler melalui tahapan data display, data reduction, penarikan kesimpulan. Hasil penelitian menunjukkan bahwa; strategi komunikasi humas KPCPEN dalam meningkatkan public trust berhasil dengan meningkatnya rasa percaya dan kemauan untuk divaksinasi.Kata Kunci: Hubungan Masyarakat, Komunikasi, Kepercayaan Masyarakat
PERAN PUBLIC RELATIONS PT ASTRA INTERNATIONAL, TBK PADA PROGRAM CSR “NURANI ASTRA” DI MASA PANDEMIK COVID-19
Authors: Uljanatunnisa Uljanatunnisa , Mahdalena Vina
Published: October 2022

Pandemi Covid-19 telah berdampak luas pada berbagai sector di Indonesia, Covid-19 menciptakan dua kondisi yang harus dihadapi perusahaan. Disatu sisi kondisi untuk tetap mempertahankan operasionalnya, kondisi lain juga menuntut perusahaan untuk memberikan kontribusi, atau memenuhi harapan stakeholdernya sebagai bentuk tanggung jawab mereka. Kondisi ini tentunya dialami oleh PT Astra International,Tbk. Ditengah upaya untuk tetap bertahan, PT Astra juga berupaya untuk memenuhi kebutuhan para stakeholdernya melalui kegiatan tanggung jawab sosial perusahaan. Dengan menggunakan Teori stakeholder dan Proses manajemen peneliti ini akan memfokuskan pada peran PR PT Astra serta menganalisis peran stakeholder pada program CSR di masa pandemik. Pendekatan yang digunakan pada penelitian ini adalah kualitatif dengan metode deskirptif. Hasil penelitian menunjukan bahwa untuk memenuhi kebutuhan dan harapan stakeholdernya PR pada program CSR melakukan Langkah-langkah seperti identfikasi masalah, tindakan komunikasi, evaluasi hingga pelaporan. Selain itu, untuk mencapai keberhasilan program, PR bersinergi dengan berbagai stakeholder. Dimana masing-masing stakeholder memiliki peran besar untuk mendukung program CSR.
PERUBAHAN PARADIGMA PENELITIAN ILMU KOMUNIKASI (DARI PARADIGMA KLASIK MARXISME - HEGELIAN MENUJU PARADIGMA KRITIS MAZHAB FRANKFURT)
Authors: Azwar Azwar
Published: October 2022

Abstrak. Tulisan ini mengungkapkan bagaimana pergeseran paradigma penelitian ilmu komunikasi dari paradigma klasik/positivisme kepada paradigma alternatif (konstruktivisme dan kritis). Membahas pergeseran paradigma klasik menuju paradigma alternatif mau tidak mau membahas perkembangan intelektual Marxisme – Hegelian yang menganut paradigma klasik dan perkembangan intelektual Mazhab Frankfurt yang kritis. Penelitian ini dilakukan dengan pendekatan metode kualitatif, yaitu metode yang bertujuan untuk menggali fenomena sosial secara khusus. Berdasarkan tempatnya, penelitian ini merupakan studi kepustakaan dimana penelitian untuk menulis artikel ini dilakukan dengan menggunakan dokumentasi atau studi literatur (kepustakaan) dari penelitian sebelumnya atau dari dokumen terkait lainnya. Hasil penelitian ini menunjukkan bahwa pada dasarnya paradigma kritis dalam ilmu sosial termasuk ilmu komunikasi berakar dari paradigma klasik. Khusus dalam penelitian ilmu komunikasi paradigma kritis tidak menginginkan komunikasi hanya sebagai sebuah metode kerja untuk menundukkan manusia saja, akan tetapi dalam paradigma kritis, komunikasi diharapkan menjadi jalan pembebasan.
Kajian Model U- Curve Terhadap Fenomena Adaptasi Pedagang Asli dengan Pedagang Pendatang di Kawasan Kalijodo Jakarta
Authors: Christanti Maria Febiana , Mardani Puri Bestari
Published: October 2022

Penelitian ini mengulas proses adaptasi antara pedagang asli dan pendatang pada fenomena penataan kawasan Kalijodo. Penelitian ini penting untuk melihat bahwa proses adaptasi dapat membantu penyelesaian konflik identitas budaya berbeda. Peneliti menggunakan model U-Curve dari Sverre Lysgaard yang menekankan proses adaptasi sebagai proses berkelanjutan dan fokus kepada pendatang (mereka yang bermigrasi). Penelitian ini menggunakan paradigma interpretive dengan metode studi kasus.. Hasil penelitian ini mengungkap bahwa para pedagang kalijodo melewati fase honeymoon di mana pedagang lama dan baru merasa kawasan lebih tertata dan tidak kumuh. Ketika masuk dalam fase kejutan budaya merupakan masa-masa terberat, terutama konflik timbul soal kepentinggan kekuasaan dan ekonomi. Pada fase penyesuaian mereka menemukan kenyamanan ketika melalukan akomodasi dalam berkomunikasi. Proses adaptasi berjalan terutama di mana pendatang baru berupaya untuk menyesuaikan aturan dan identitas budaya pedangang lama.
Revisão sistemática sobre feedback da avaliação de Matemática para estudantes com Transtorno do Espectro Autista de 2012-2021
Authors: Cardoso da Cruz Francerly , Eustáquio Moreira Geraldo
Published: October 2022

O presente artigo objetiva identificar teses e dissertações brasileiras que, entre 2012 e 2021, abordaram o feedback da avaliação no ensino e aprendizagem da matemática na perspectiva inclusiva dos estudantes com Transtorno do Espectro Autista (TEA). Para tanto, realizou-se uma revisão sistemática com abordagem qualitativa, de cunho exploratório. Foram encontradas 11 pesquisas que perpassaram os focos temáticos delimitados neste estudo: inclusão escolar, TEA, avaliação, matemática, ensino e aprendizagem. O foco temático matemática teve a maior representatividade, estando presente em nove pesquisas, seguido de avaliação, com seis pesquisas ao todo. Quatro pesquisas abordaram a inclusão; cinco abordaram o TEA e nenhuma das 11 pesquisas, referiu-se ao foco feedback. Os resultados reforçam a necessidade de realizar estudos que abordem o feedback em prol de uma avaliação mediadora no ensino e aprendizagem da matemática, o que pode contribuir tanto para a inclusão de estudantes com TEA, como para os demais, que apresentam ou não alguma necessidade educacional específica.
Programa Residência Pedagógica: motivações, experiências e contribuições a partir da percepção de residentes e preceptores de Educação Física
Authors: Machado de Asambuja Wellerson , Fernandes Martins João Francisco , Copetti Jaqueline , Vilanova Ilha Phillip , Godinho Soares Renata
Published: October 2022

O presente estudo trata sobre a formação de professores enquanto licenciandos em Educação Física, e também quanto à formação continuada de professores da educação básica, através do Programa Residência Pedagógica (PRP). Busca-se com o presente estudo, identificar as percepções dos residentes e preceptores do núcleo de Educação Física do PRP-UNIPAMPA quanto às motivações, experiências e contribuições do programa para com os mesmos. Caracteriza-se como uma pesquisa de abordagem qualitativa com caráter exploratório descritivo, fizeram parte do estudo apenas os participantes do módulo II do Programa. Como instrumento de coleta de informações, foi elaborado pelos autores um formulário no Google Forms que foi encaminhado aos participantes via WhatsApp para que os mesmos pudessem fazer suas contribuições de forma voluntária com a pesquisa. Os principais resultados levantados evidenciam a expectativa dos residentes em adquirir aprendizado e experiência, vivenciando a realidade escolar e desenvolvendo a regência de classe o que os proporcionou um crescimento profissional, já para os preceptores as motivações e expectativas com o programa estiveram relacionadas com o desenvolvimento profissional docente e contribuição na formação dos residentes.
Mapeamento longitudinal da retenção e evasão em cursos de licenciatura como contribuição à governança educacional: um estudo de caso no Instituto Federal de Minas Gerais
Authors: Silva Adacuí , Junior Niltom
Published: October 2022

Este artigo analisa as movimentações e os fluxos escolares dos alunos nos cursos de licenciatura ofertados no Instituto Federal de Educação, Ciência e Tecnologia de Minas Gerais (IFMG), cujo recorte temporal (ciclo de matrícula) se dá no período de 2012 a 2020. A pesquisa, nesta sua primeira fase, restringiu-se a descrever os fenômenos da retenção e evasão, a partir de múltiplos estudos de caso (vários ciclos de matrícula), análise documental e da análise quantitativa. Após o mapeamento foi possível constatar um baixo número de formandos (aproximadamente 10%) e um elevado número de evasão/desligamento (aproximadamente 50%), o que indica a necessidade de políticas públicas que maximizem a permanência dos alunos destes cursos até a conclusão do curso.
Prevalence of dysglycemia and associated risk factors in patients with pancreatic benign and low-grade malignant tumors before pancreatic surgery: A prospective observational study
Authors: Yang Jie , Zhang Jia , Wang Rui , Liu Ya , Chen Yonghua
Published: October 2022

Background

Pancreatic benign and low-grade malignant tumors (PBLMT) have experienced a rapid increase in incidence rates worldwide. Few studies have focused on the glucose metabolism status of patients with PBLMT before pancreatic surgery.

Methods

From August 2017 to June 2018, 70 patients with PBLMT were prospectively screened for abnormalities in glucose metabolism by an oral glucose tolerance test (OGTT) before pancreatic surgery. Patients were classified as having normal glucose tolerance (NGT), prediabetes mellitus (pre-DM), or new-onset DM (NOD) according to the American Diabetes Association (ADA) criteria. Glucose metabolism indices were calculated based on the OGTT parameters. Tumor volume and remnant pancreatic volume (RPV) were measured by computed tomography.

Results

Forty-nine of 70 patients with PBLMT developed dysglycemia (pre-DM and NOD). RPV was smaller in the pre-DM (57.44 ± 18.20 cm3 vs. 70.48 ± 14.08 cm3, P = 0.001) and NOD groups (37.38 ± 20.40 cm3 vs. 70.48 ± 14.08 cm3, P < 0.001) than in the NGT group. The homeostasis model assessment of β-cell function (HOMA2-β), insulinogenic index (IGI), and insulin secretion/insulin resistance index (ISSI-2) were worse in the pre-DM and NOD groups compared with NGT group (all P < 0.05). After univariate and multivariate analyses, age over 60 years (P = 0.049, OR = 5.76, 95% CI: 1.01-32.92) and RPV less than 49.36 cm3 (P = 0.024, OR = 8.59, 95% CI: 1.34-55.22) were recognized as independent risk factors for dysglycemia. The analysis of all patients revealed inverse correlations between RPV and both in age (r = -0.28, P = 0.019) and tumor volume (r = -0.28, P = 0.032). Positive correlations were found between RPV and both IGI (r = 0.29, P = 0.019) and ISSI-2 (r = 0.39, P = 0.0011).

Conclusion

In patients with PBLMT, 70% had dysglycemia before surgery. Old age and a reduction in RPV were independent risk factors for developing dysglycemia before pancreatic surgery. The decisions to treat PBLMT with resection should hinge more on the risk of dysglycemia as well as potential malignancy.
Interaction between gut microbiota and immune checkpoint inhibitor-related colitis
Authors: Zhou Guanzhou , Zhang Nana , Meng Ke , Pan Fei
Published: October 2022

Immune checkpoint inhibitors (ICIs) have become a promising therapeutic strategy for malignant tumors, improving patient prognosis, along with a spectrum of immune-related adverse events (irAEs), including gastrointestinal toxicity, ICI-related colitis (IRC), and diarrhea. The gut microbiota has been suggested as an important regulator in the pathogenesis of IRC, and microbiota modulations like probiotics and fecal microbiota transplantation have been explored to treat the disease. This review discusses the interaction between the gut microbiota and IRC, focusing on the potential pathogenic mechanisms and promising interventions.
CAPN8 involves with exhausted, inflamed, and desert immune microenvironment to influence the metastasis of thyroid cancer
Authors: Zhong Xiang , Xu Shu , Wang Quhui , Peng Long , Wang Feiran , He Tianyi , Liu Changyue , Ni Sujie , He Zhixian
Published: October 2022

Background

Thyroid cancer (THCA) is the most prevalent malignant disease of the endocrine system, in which 5-year survival can attain about 95%, but patients with metastasis have a poor prognosis. Very little is known about the role of CAPN8 in the metastasis of THCA. In particular, the effect of CAPN8 on the tumor immune microenvironment (TIME) and immunotherapy response is unclear.

Material and methods

Multiome datasets and multiple cohorts were acquired for analysis. Firstly, the expression and the prognostic value of CAPN8 were explored in public datasets and in vitro tumor tissues. Then, hierarchical clustering analysis was performed to identify the immune subtypes of THCA according to the expression of CAPN8 and the activities of related pathways. Subsequent analyses explored the different patterns of TIME, genetic alteration, DNA replication stress, drug sensitivity, and immunotherapy response among the three immune phenotypes. Finally, five individual cohorts of thyroid cancer were utilized to test the robustness and extrapolation of the three immune clusters.

Results

CAPN8 was found to be a significant risk factor for THCA with a markedly elevated level of mRNA and protein in tumor tissues. This potential oncogene could induce the activation of epithelial–mesenchymal transition and E2F-targeted pathways. Three subtypes were identified for THCA, including immune exhausted, inflamed, and immune desert phenotypes. The exhausted type was characterized by a markedly increased expression of inhibitory receptors and infiltration of immune cells but was much more likely to respond to immunotherapy. The immune desert type was resistant to common chemotherapeutics with extensive genomic mutation and copy number variance.

Conclusion

The present study firstly explored the role of CAPN8 in the metastasis of THCA from the aspects of TIME. Three immune subtypes were identified with quite different patterns of prognosis, immunotherapy response, and drug sensitivity, providing novel insights for the treatment of THCA and helping understand the cross-talk between CAPN8 and tumor immune microenvironment.
Knowledge mapping and current trends of immunotherapy for prostate cancer: A bibliometric study
Authors: Zhong Weibo , Shen Zefeng , Wu Yongxin , Mao Xiangming , Kong Jianqiu , Wu Weixia
Published: October 2022

Background

Prostate cancer (PCa) is the second most common malignancy in men worldwide. Growing evidence substantiates the important role of immunotherapy in human tumors. Given that immunotherapy is often unsatisfactory on PCa, many studies have been conducted on PCa immunotherapy to improve treatment efficacy. However, no relevant bibliometric study of PCa immunotherapy has hitherto been reported. A bibliometric analysis was performed to evaluate the global scientific production of PCa immunotherapy research and characterize the development trends for future studies in this article.

Methods

The publications related to PCa immunotherapy were extracted from the Web of Science Core Collection. The contribution and co-occurrence relationships of countries/regions, institutions, journals, references, authors, and keywords were assessed and visualized by VOSviewer and CiteSpace to identify research hotspots and potential future trends.

Results

A total of 3,583 publications related to PCa immunotherapy from 1999 to 2021 were collected. The results of annual publications and citations exhibited a steady increase over the past 22 years. The National Cancer Institute in the USA published far more papers during the study than any institute. Accordingly, the USA had the most publications (n = 1,954, 54.54%). Gulley, James L. had the most number of published papers, and Small, Eric J. was the most co-cited authors in this field. Cancer Immunology Immunotherapy was the most productive journal, with 145 publications on PCa immunotherapy. Keyword cluster and keyword burst analyses showed that research in PCa immunotherapy shifted from “t cell infiltration” and “sipuleucel t” to “immune checkpoint inhibitor”, “CTLA-4”, and “PD-L1 expression”.

Conclusion

PCa immunotherapy has attracted much attention, reflected by the increasing number of annual publications and citations. Much emphasis has been placed on exploring the complex immunogenicity and tumor microenvironment for PCa and identifying the patient population who can benefit from immunotherapy. Combining immune checkpoint inhibitors with other therapeutic options and cancer vaccines represents the future development trends in PCa immunotherapy.
Targeting transmembrane-domain-less MOG expression to platelets prevents disease development in experimental autoimmune encephalomyelitis
Authors: Cai Yuanhua , Schroeder Jocelyn A. , Jing Weiqing , Gurski Cody , Williams Calvin B. , Wang Shaoyuan , Dittel Bonnie N. , Shi Qizhen
Published: October 2022

Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system with no cure yet. Here, we report genetic engineering of hematopoietic stem cells (HSCs) to express myelin oligodendrocyte glycoprotein (MOG), specifically in platelets, as a means of intervention to induce immune tolerance in experimental autoimmune encephalomyelitis (EAE), the mouse model of MS. The platelet-specific αIIb promoter was used to drive either a full-length or truncated MOG expression cassette. Platelet-MOG expression was introduced by lentivirus transduction of HSCs followed by transplantation. MOG protein was detected on the cell surface of platelets only in full-length MOG-transduced recipients, but MOG was detected in transmembrane-domain-less MOG1-157-transduced platelets intracellularly. We found that targeting MOG expression to platelets could prevent EAE development and attenuate disease severity, including the loss of bladder control in transduced recipients. Elimination of the transmembrane domains of MOG significantly enhanced the clinical efficacy in preventing the onset and development of the disease and induced CD4+Foxp3+ Treg cells in the EAE model. Together, our data demonstrated that targeting transmembrane domain-deleted MOG expression to platelets is an effective strategy to induce immune tolerance in EAE, which could be a promising approach for the treatment of patients with MS autoimmune disease.