bluuebunny/crossref_metadata_2025 huggingface dataset:
Faktor-Faktor yang Berhubungan dengan Stres pada Mahasiswa STIKes PHI dalam Menyusun Tugas Akhir
Authors: Agustina Agustina , Halawa Wilia
Published: May 2022

Stress dalam belajar terjadi jika ada suatu tekanan-tekanan ataupun ketidaknyamanan dalam belajar yang dialami oleh mahasiswa. Data Riset Kesehatan Dasar (Riskesdes) pada tahun 2013, menyebutkan bahwa sekitar 1,33 juta penduduk DKI Jakarta mengalami stress, dimana angka tersebut mencapai 14% dari total penduduk, dengan stress akut mencapai 1-3% dan stress berat mencapai 7-10%. Tuntutan dari kampus yang harus mewajibkan segera menyelesaikan skripsi dan kesulitan yang dialami selama proses penyusunan skripsi akan menjadi tekanan bagi mahasiswa sehingga bisa mengalami stres. Tujuan penelitian ini untuk mengetahui faktor-faktor yang berhubungan dengan stress pada mahasiswa STIKes PHI  dalam menyusun tugas akhir tahun 2019. Penelitian ini merupakan studi kuantitatif dengan rancangan Cross Sectional.  Variabel terikat  adalah stres pada mahasiswa, dan variabel bebasnya adalah faktor internal dan eksternal. Penelitian dilakukan di STIKes Persada Husada Indonesia di Kampus B, Jati Asih Kota Bekasi tahun 2019. Sampel dalam penelitian ini adalah seluruh mahasiswa tingkat akhir sebanyak 50 orang. Pengumpulan data itu sendiri dengan menggunakan kuesioner. Analisa data yang digunakan dalam penelitian ini dengan menggunakan analisis univariat dan bivariat (menggunakan analisis chi square dengan tingkat kepercayaan α =0,05). Hasil penelitian menunjukkan bahwa mayoritas responden perempuan, terbanyak berkepribadian baik, memiliki pemahaman yang tinggi, dan menganggap tuntutan tugasnya berat. Pada faktor eksternal lingkungan sosial dan dukungan keluarga terbanyak mendukung mahasiswa. Untuk tingkat stres, mayoritas mahasiswa menderita stres ringan.
Asuhan Keperawatan Klien yang Mengalami Bersihan Jalan Nafas Tidak Efektif dengan Tuberkulosis Paru di RSAU dr. Esnawan Antariksa Jakarta Timur
Authors: Vestabilivy Evi , Marzuki Marzuki
Published: May 2022

Tuberculosis paru adalah penyakit infeksi yang menyerang parenkim paru-paru, disebabkan oleh Mycobacterium tuberculosa. Hasil penelitian pada tahun 2016 jumlah penderita penyakit tuberculosis paru sebanyak 233 penderita dan pada tahun 2017 terjadi peningkatan penderita Tuberculosis Paru sebesar 267 orang. Studi kasus ini bertujuan untuk memperoleh gambaran pelaksanakan asuhan keperawatan klien yang mengalami bersihan jalan nafas tidak efektif dengan tubercolusis paru di RSAU dr. Esnawan Antariksa Jakarta Timur. Penelitian telah dilaksanakan di ruang Merpati dan Garuda pada bulan Maret – April 2018 pada kedua pasien selama 3 hari. Metode penelitian yang digunakan adalah metode penelitian kualitatif deskritif pendekatan studi kasus dengan intervensi yaitu mengajarkan batuk efektif. Partisipan dalam studi kasus ini adalah dua orang klien, dua orang anggota keluarga klien, dan dua orang perawat ruangan. Pada tahap pengkajian didapatkan data subjektif pada kedua klien sama-sama mengeluh batuk berdahak lebih dari 2 minggu. Data objektif kedua klien tampak batuk, batuk disertai dengan sputum berwarna kuning. Diagnosa keperawatan prioritas utama pada kedua klien tuberculosis paru adalah bersihan jalan nafas tidak efektif berhubungan dengan penumpukan sekret. Pada tahap perencanaan diagnosa prioritas masalah ditetapkan rencana tindakan keperawatan yang mengacu pada tujuan dan kriteria hasil. Berdasarkan diagnosa keperawatan diatas tindakan keperawatan yang dilakukan adalah mengajarkan batuk efektif dengan frekuensi setiap 2 jam dilakukan selama 3 hari. Evaluasi masalah keperawatan bersihan jalan nafas tidak efektif berhubungan dengan penumpukan sekret teratasi ditandai dengan batuk sudah berkurang. Klien tampak bisa mengeluarkan sputum, suara nafas vesikuler, frekuensi pernafasan 20 kali/menit sehingga intervensi dihentikan. Kesimpulan tidak ada kesenjangan antara teori dan fakta yang didapat pada asuhan keperawatan pada klien yang mengalami bersihan jalan nafas tidak efektif dengan tuberculosis paru di RSAU dr. Esnawan Antraiksa Jakarta.
El Barranco Hondo de La Victoria y el Barranco de Añavingo de Arafo: dos propuestas de actuación y gestión patrimonial de los paisajes culturales de Tenerife
Authors: Afonso Domínguez Adrián , Fariña Fariña Laura
Published: May 2022

The development of the traditional communities in Canary Island have passed by an intense process of exploitation of territorial resources which are part of its cultural identity. In this context stand the ravines out like dynamic spaces that offer a wide variety of resources to the development of socio-economic activities. Actually, these are displayed as important cultural landscapes which have been undervalued and forgotten but they continue to be part of the Canary Cultural Heritage, both tangible and intangible.
Cinéma: Um Jogo para Auxílio no Ensino de Audiovisual em um curso de Computação Gráfica
Authors: Silva Fellipe Mayan da , Araujo Filho Aldair Oliveira , Monteiro Romulo Barbosa de Alencar , Ferreira Andressa Bezerra , Oliveira Samuel Levi Silva de
Published: May 2022

O presente artigo relata a experiência do desenvolvimento de um jogo de tabuleiro virtual para disciplina do curso técnico de Computação Gráfica.Link para o vídeo da apresentação: https://youtu.be/13ZuAnMBwqc
Análise do papel das GitHub Discussions no ambiente de desenvolvimento de Software Livre
Authors: Maciel Ana Claudia , Wiese Igor , Steinmacher Igor
Published: May 2022

GitHub Discussions é uma nova funcionalidade do GitHub que possibilita a abertura de discussões, e perguntas e respostas, fora do ambiente das pull requests e issues. Dada a novidade desta funcionalidade, é importante entender o papel que ela desempenha na entrada de novatos e sustentabilidade de projetos no GitHub. Assim, o objetivo deste trabalho é analisar a relação das GitHub Discussions com as issues e pull requests e investigar como as discussões podem impulsionar a entrada de novos contribuidores. Em análises preliminares com o projeto Vercel/next.js, nota-se que um grande número de usuários teve sua primeira interação no projeto por meio das GitHub Discussions e que uma pequena parcela se envolveu em issues e pull requests. Como consolidação deste trabalho, novos projetos serão analisados e novas análises serão realizadas a fim de ter uma melhor compreensão do papel das GitHub Discussions no ecossistema do GitHub.
What's behind a first impression? Implications for portrait selection on gig work platforms
Authors: Nascimento Leon de França , Garcia Ana Cristina Bicharra
Published: May 2022

O gig work é uma forma emergente de trabalho que vem ganhando atenção por induzir mudanças nas dinâmicas de poder entre empregadores e empregados. Uma questão premente é a disponibilidade limitada de informações para um encaixe pessoa-emprego: na maioria das vezes, um retrato de perfil e uma pequena biografia são as únicas informações disponíveis para seleção, tornando essa forma de seleção sujeita a preconceitos sobre raça, sexo ou idade. Este estudo visa explorar as relações entre empregabilidade e atributos faciais usando um pipeline de processamento de imagem proposto para avaliar atributos raciais, sexuais, idade percebida e emoção percebida usando o conjunto de dados de treinamento ChaLearn Looking at People First Impressions V2.
Der „bayerische Weg" in der Datenschutzaufsicht
Authors: Blum Lucas Ben
Published: May 2022

In the early days of data protection supervision, supervision of processing in the public and non-public sectors was predominantly carried out by different authorities in the states. Today, this division of supervision (the so called “Trennungsmodell”) is only found in Bavaria. Both the reasons that led to the merging of data protection authorities and the question of whether the Trennungsmodell is preferable to the so-called Einheitsmodell are examined. Relating thereto it is examined whether data protection supervision in the non-public sector needs to be reformed. With a view to a possible centralization of supervision in the non-public sector, the Trennungsmodell could ultimately prevail.
Der Schutz grafischer Gebrauchsgestaltungen
Authors: Hozuri Behyad
Published: May 2022

The work discusses the protection of graphic-communicative forms of use, through copyright-, design-, trademark- and competition law.

Pictorial symbols and graphical designs have been means of visual communication since ancient times. Even today, advertising graphics, pictograms or business signs are used in daily communication to convey messages. The study examines the legal protection of such forms of communication. While copyright law can be identified as the primary institution of protection, the question of the relationship to and the distinction from design law is also examined, and the question of an independent protection of the communication value conveyed by a sign via trademark law is addressed.
Economic justification of applying information technologies to the creation of smart cities
Authors: Cvetković Aleksandar , Radojčić Vesna
Published: May 2022

Modern technologies, in addition to making people's lives easier, faster and better, enable the combination of different technologies to develop solutions to various problems. Global warming is one of the biggest and most dangerous problems facing planet earth. If global warming were presented as a coin, then air pollution and climate change would be two sides of the same coin. Climate change is primarily a problem that has arisen due to the large amount of carbon dioxide (CO2 ) in the atmosphere. Carbon overload occurs mainly due to the combustion of fossil fuels such as coal, oil and gas, or the cutting and burning of forests. There are other harmful gases but CO2 stands out because it poses the greatest risk of irreversible change if it continues to accumulate in the atmosphere. This paper presents a number of different solutions by combining modern technologies for the problem of CO2 emissions globally, where Bosnia and Herzegovina is particularly singled out as one of the countries with the most polluted air in Europe and with the highest mortality rate associated with air pollution. Smart cities use digital technologies, aim to improve the quality of human life and to enable the protection of the environment. The concept of a smart city is described as a set of modern technologies, examples of leading smart cities in the world are given, as well as the advantages of implementing such a solution.
Vitam instituere:
Authors: Costa William
Published: May 2022

Objetivo central deste artigo é apresentar e articular as categorias de biopolítica afirmativa e pensamento instituinte na filosofia de Roberto Esposito. Pretendemos sustentar a tese de que a biopolítica, uma vez relacionada com o pensamento, pode fazer emergir práticas éticas e políticas de proteção e de expansão da potência da vida. À medida que a biopolítica afirma a potência humana e o pensamento amplia esse imaginário simbólico, possibilita-se a instituição de práxis sociais e de agires políticos singulares e coletivos. Para sustentar e apresentar essas ideias, o artigo organiza-se em dois momentos: (i) inicialmente, buscamos reconstruir a reflexão de Esposito sobre a biopolítica e sobre a construção do paradigma imunitário. Assumiremos como pano de fundo a interlocução do pensador italiano com Michel Foucault, destacando os contrastes e tensões que levaram Esposito àquilo entendido por ele como a chave hermenêutica que completa a explicação da biopolítica; (ii) em seguida, objetivamos mostrar como a “caixa preta da biopolítica” pode deslocar o pêndulo imunitário afirmativo da vida e, junto à potência do pensamento, pode instituir imaginários e práxis sociais.
Machinima, posfotografía y posanimación: estudio comparativo disciplinar
Authors: Alonso Calero José María
Published: May 2022

En esta investigación se propone una convergencia entre el campo del machinima, la posfotografía y la posanimación, que son disciplinas distantes pero afines en factores y claves por haberse desarrollado en el ámbito de la red. A partir del rol de intermediación entre disciplinas que juega el machinima, y tomando de la metodología cualitativa el estudio de casos desde la triangulación teórica, planteamos un estudio comparativo cuya hipótesis propone una secuencia formada por la posfotografía, el machinima y la posanimación hasta llegar a la real-time animation. Establecidas las claves principales sobre autoría, automatización y apropiación (donde la mediación y la autorreferencialidad son determinantes) inscritas en «Por un manifiesto post-fotográfico», vamos a extraer una serie de claves «post» que nos van a guiar en el análisis de estas disciplinas, para así generar una taxonomía cruzada. Taxonomía que pretende poner en valor el machinima en relación con la animación más avanzada y conectarla con la animación en tiempo real. Todo ello con el objetivo de reflexionar sobre la consideración de la real-time animation como la posanimación, lo que implica, primero, señalar el paralelismo entre estas disciplinas que se han ido estableciendo en la creación audiovisual; y, segundo, presupone una convergencia entre medios propiciada por una posible condición «post». El resultado es una serie de claves «post» A y B; una taxonomía cruzada con las que tratamos de entender cómo la implantación de lenguajes híbridos crea correspondencias interdisciplinares.
Dual Innervation to the Gluteus Maximus: A Case Report with Clinical Implications
Authors: Rodríguez Jailenne I Quiñones- , Quiñones Amarilis Camacho- , Suárez Natalia Y Cárdenas- , Ramírez Norman
Published: May 2022

Anatomical variations of the gluteus maximus have significant clinical implications. The gluteus muscle is commonly innervated by the Inferior Gluteal Nerve (IGN). However, this innervation could be affected by its embryological development. An anomalous innervation of the gluteus maximus by the Sciatic Nerve (SN) was identified during a bilateral dissection of the gluteal region. Dissection was performed on an elderly female cadaver, preserved with 10% formalin, and performed following the guidelines given in Grant’s Dissector 16th edition. The left and right gluteus maximus were innervated by their corresponding IGN. However, both demonstrated an additional innervation by the SN. This branch by the SN was located proximal to the IGN and emerged near the inferior border of the piriformis muscle. Patients with dual gluteus maximus innervation can present with clinical signs and symptoms which might be easily misdiagnosed. Therefore, physicians need to be aware of this abnormal innervation to accurately diagnose and avoid potential iatrogenic nerve injuries during interventions.
Recurrent Botryomycosis and Management Strategy with a Follow-up of Four Years: A Case Report
Authors: Thilak PS Gopinath , Radhakrishnan Sharanyamenon
Published: May 2022

Cervicofacial botryomycosis is a chronic, granulomatous suppurative infection with varied presentations in the head and neck region. Since the discovery of this entity, treatment has been elusive without evidence of complete resolution of the lesion with a long period of follow-up. Here the authors report a case of cervicofacial botryomycosis with oral manifestations in a 37-year-old male patient with a history of trauma, for whom the authors devised a treatment plan tailored to the patient's microbiological profile after culture and sensitivity testing in addition to systemic and local antibiotic therapy and heat therapy which showed drastic regression of the lesion and an improved mouth opening. The patient has been under follow-up for the past four years without signs of recurrence. Botryomycosis is an aggressive lesion where a surgery-only approach is usually futile and requires further intervention due to recurrences. The present experience suggests surgical debridement along with antibiotic and local heat therapy to be effective in managing this usually recurring lesion.
Preparing for the Future: Diversity in Chiropractic Education: Chiropractic Educators Research Forum (CERF), December 4, 2021
Authors:   Chiropractic Educators Research Forum
Published: May 2022

This conference was convened by the Chiropractic Educators Research Forum (CERF) on December 4, 2021. This meeting provided a forum for the presentation of scholarly works in education theory and practice. This conference specifically focused on research related to diversity, equity, and inclusion. During the December 2021 CERF meeting, presenters and panelists took an in depth look at how chiropractic programs work to address diversity issues in the changing landscape of healthcare and to address the needs of the world population.
Synthesis, Crystal Structure and Catalytic Activity of Tri-Nuclear Zn(II) Complex Based on 6-Phenylpyridine-2-carboxylic Acid and Bis(4-pyridyl)amine Ligands
Authors: Wang Li-Hua , Kong Fan-Yuan , Xi-Shi Tai
Published: May 2022

A new trinuclear Zn (II) complex, [Zn3(L1)4(L2)2(CH3COO)2] (1) (HL1 = 6-phenylpyridine-2-carboxylic acid, L2 = bis(4-pyridyl)amine) has been synthesized by 6-phenylpyridine-2-carboxylic acid, NaOH, bis(4-pyridyl)amine and Zn(CH3COO)2•2H2O. The complex 1 has also been structural characterized by elemental analysis and single crystal X-ray diffraction. The results reveals that complex 1 is made up of three Zn(II) ions, four L1 ligands, two L2 ligands and two CH3COO- anions. In 1, both Zn1 ion and Zn1a ion are five-coordinated with two O atoms from two different L1 ligands, two N atoms from two different L1 ligands, and one N atoms from bis(4-pyridyl)amine ligand, respectively, and forms a distorted trigonal biyramid geometry. And Zn2 ion is four-coordinated with two O atoms from two different CH3COO− anions and two N atoms from two different L2 ligands, forming a distorted tetrahedral geometry. Complex 1 displays a 3D network structure by the intermolecular N−H···O hydrogen bonds. The catalytic performance for oxidation of benzyl alcohol with O2 was studied under mild reaction conditions using complex 1 as catalyst. The results demonstrated that the catalysts were very active, and the yield of benzaldehyde was 50.8% at 90 °C with THF as solvent under 0.5 MPa O2 within 3 h. Copyright © 2022 by Authors, Published by BCREC Group. This is an open access article under the CC BY-SA License (https://creativecommons.org/licenses/by-sa/4.0).
Estudo do perfil sócio digital de estudantes do curso de pedagogia da UFBA no contexto da Covid-19
Authors: Rocha Telma Brito , Menezes Karina Moreira , Souza Lanara Guimarães de
Published: May 2022

O presente artigo tem como objetivo analisar os desafios provocados pela pandemia da COVID-19, causada pelo vírus Sars-COV-2, no contexto educacional dos estudantes do curso de Licenciatura em Pedagogia, da Universidade Federal da Bahia - UFBA. O texto dedica-se a revelar como a necessidade de distanciamento social exigiu novos arranjos educacionais, impondo a urgência de mediação tecnológica, onde acentua-se a desigualdade econômica e social historicamente arraigada em nossa sociedade. O diálogo proposto neste trabalho se fez com os teóricos (CASTELLS, 1999), (NÓVOA, 2020), (TARDIF, 2014), (PRETTO, 2020), entre outros. Como construtos metodológicos da pesquisa descritivo-analítica realizada, apresentamos o perfil sociodigital de discentes, traçado a partir de 223 questionários respondidos. Os resultados iniciais do estudo aqui apresentado revelam que os estudantes possuem poucos e inadequados equipamentos tecnológicos, baixa qualidade de acesso à internet, além da fragilidade de condições cognitivas, emocionais ou econômicas para estudar; impondo às universidades a necessidade de refletir sobre a formação de professores no ensino superior, neste contexto de sindemia.
Situações de coautoragem online no ensino fundamental
Authors: Carvalho Felipe
Published: May 2022

Neste artigo, relato experiências de pesquisa e formação de dez anos como professor da disciplina de Informática na Educação no ensino fundamental. Parto dos estudos ciberculturais e da educação online para pensar as situações de coautoragem propostas com as/os estudantes do 5° ano e 6° ano em duas escolas da mesma rede de ensino. Situações de coautoragem se referem a situações de aprendizagem que requerem a manifestação do pensamento crítico e da autoria criativa. Inspiro-me na epistemologia das práticas acoplada à pesquisa (auto)biográfica para refletir sobre três situações: uma produzida com o uso de editores de apresentação online, outra com podcasting e uma terceira com uso de mapas online. Considero essas situações relevantes para contribuir com as discussões sobre as pedagogias do presente, marcadas pela educação online, ensino remoto e educação híbrida. Destaco, como achados desta pesquisa, que as situações de coautoragem precisam estar contextualizadas na vida cotidiana da/o estudante e nas práticas (ciber)culturais, potencializam a expressão de si com a/o outra/o e podem inspirar outras práticas educativas além das listas de exercícios e questionários.
Vidas inimigas, necropolítica e interseccionalidade: da exclusão na educação ao suicídio/assassinato de pessoas trans
Authors: Pereira Goulart Vincent , Caetano Nardi Henrique
Published: May 2022

Em tempos de fortalecimento de governos de extrema-direita em aliança com os fundamentalismos religiosos, a guerra contra populações acusadas de ser inimigas das igrejas cristãs, da família e dos bons costumes é reforçada explicitamente por meio de políticas conservadoras e genocidas. Esse projeto genocida e epistemicida tem fortes raízes estruturais, fruto do projeto colonial, derivado, sobretudo, da invasão branca europeia do nosso continente. As pessoas negras enfrentam políticas de extermínio de suas tradições, identidades, suas histórias e de suas vidas. Pessoas negras, transsexuais e travestis, pobres, especialmente, são os principais alvos dessas políticas de morte. Essas necropolíticas marcadas pelas suas especificidades na ação do Estado, inicia na exclusão da escola e chega ao homicídio propriamente dito, seja por meio da produção do suicídio - pessoas suicidadas intencionalmente pelo Estado, seja pela vulnerabilidade social seja pela violência cotidiana. Pessoas trans e travestis têm sido historicamente objeto de classificação e diagnóstico pelas ciências biomédicas e psi, mediante critérios que desconsideram a singularidade de trajetórias de cada sujeito, bem como sua humanidade. Esses grupos enfrentam a patologização de seus corpos, bem como o abandono e as violências estruturais como crime de Estado. Neste artigo buscamos diagramar os mecanismos necropolíticos por meio da análise de fontes múltiplas, sobretudo aquelas de domínio público, dados estatísticos, relatos de exclusão escolar e violência publicados nas redes sociais. Nos valeremos de uma análise dos enunciados ali presentes na descrição dos mecanismos de exclusão e morte conduzidos pelo Estado.
Faíscas, lampejos e fragmentos luminosos entre teatro e performance no Teatro da Vertigem
Authors: Silva Eduardo Reis , De Vilhena Deolinda Catarina França
Published: May 2022

o artigo propõe uma reflexão sobre abordagens cênicas que tangenciam zonas periféricas entre teatro e performance, do grupo paulistano Teatro da Vertigem, tendo como diretores criativos o Antônio Araújo e Eliana Monteiro. Os trabalhos teatrais deste grupo sempre flertaram e se relacionaram com a performatividade, de modo que esta relação tem se intensificado, ao ponto de em 2008 realizarem a intervenção cênica A última palavra é a penúltima, e em 2014 uma revisão da mesma, numa versão 2.0. Nesta análise, detenho-me nesta última versão, onde o grupo trilha por uma passagem completamente emancipada de: texto, personagens delimitados, ação dramática, tempo e espaço demarcados. Apoiado pelos estudos de Érika Fischer-Lichte acerca da realidade e da ficção no teatro contemporâneo e também das análises de Jean-Pierre Sarrazac, Josette Ferál e Gilles Deleuze. Deste modo, este artigo, concentra-se nas reflexões que tencionam aproximações e experimentações performativas do Teatro da Vertigem em seus espetáculos.
No entre, à escuta
Authors: Lazzareti Angelene
Published: May 2022

RESUMO: O presente artigo reflete sobre a escuta e o entre como inspirações para uma formação artística sensível e porosa. A escuta é compreendida como ação de corpo inteiro, que possibilita testemunhar e legitimar a existência do outro. O entre é visualizado como força relacional de produção de singularidades e de fragilidades e, embora não possa ser estabilizado para ser definido ou dito, pode ser escutado. As referências deste texto são os estudos de Ivan Flores Arancibia, Jean-Luc Nancy, Mirna Spritzer, Roland Barthes e Cassiano Sydow Quilici.  Palavras-chave: Entre; Escuta; Formação artística; Corpo; Afetividade;
Ipseidade e dramaturgia contemporânea: o si e o outro em Nós, do Galpão, e Mata teu pai, de Grace Passô
Authors: De Medeiros Elen
Published: May 2022

A partir das análises das peças Nós, de Marcio Abreu e Eduardo Moreira para o espetáculo do Grupo Galpão, e Mata teu pai, de Grace Passô, pretende-se neste artigo articular as reflexões acerca da ipseidade, segundo o pensamento hermenêutico de Paul Ricoeur (2004), com as proposições acerca do drama moderno e contemporâneo, segundo Jean-Pierre Sarrazac (2017). Nesse sentido, tem-se como foco o entendimento dialético entre forma e conteúdo nas duas peças e almeja-se reconhecer como trazem consigo um debate acerca das insurgências do contemporâneo, em especial na relação entre a apresentação do si em cena no embate e na constituição com o outro.
Labirinte-se!
Authors: Mascarenhas George , Santana Ivani
Published: May 2022

Editorial - 37
IC&RC counselor concerns: Quality, not quantity
Authors: Knopf Alison
Published: May 2022

There's a lot of discussion this year, as always, about the need to beef up the addiction treatment workforce, because there aren't enough counselors or other providers. But having an adequate supply means more than quantity — it means quality.
3D Bioprinted Neural‐Like Tissue as a Platform to Study Neurotropism of Mouse‐Adapted SARS‐CoV‐2
Authors: de Melo Bruna A. G. , Mundim Mayara V. , Lemes Robertha M. R. , Cruz Elisa M. , Ribeiro Tais N. , Santiago Carolina F. , da Fonsêca Jéssica H. L. , Benincasa Julia C. , Stilhano Roberta S. , Mantovani Nathalia , Santana Luiz C. , Durães‐Carvalho Ricardo , Diaz Ricardo S. , Janini Luiz M. R. , Maricato Juliana T. , Porcionatto Marimelia A.
Published: May 2022

The effects of neuroinvasion by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) become clinically relevant due to the numerous neurological symptoms observed in Corona Virus Disease 2019 (COVID‐19) patients during infection and post‐COVID syndrome or long COVID. This study reports the biofabrication of a 3D bioprinted neural‐like tissue as a proof‐of‐concept platform for a more representative study of SARS‐CoV‐2 brain infection. Bioink is optimized regarding its biophysical properties and is mixed with murine neural cells to construct a 3D model of COVID‐19 infection. Aiming to increase the specificity to murine cells, SARS‐CoV‐2 is mouse‐adapted (MA‐SARS‐CoV‐2) in vitro, in a protocol first reported here. MA‐SARS‐CoV‐2 reveals mutations located at the Orf1a and Orf3a domains and is evolutionarily closer to the original Wuhan SARS‐CoV‐2 strain than SARS‐CoV‐2 used for adaptation. Remarkably, MA‐SARS‐CoV‐2 shows high specificity to murine cells, which present distinct responses when cultured in 2D and 3D systems, regarding cell morphology, neuroinflammation, and virus titration. MA‐SARS‐CoV‐2 represents a valuable tool in studies using animal models, and the 3D neural‐like tissue serves as a powerful in vitro platform for modeling brain infection, contributing to the development of antivirals and new treatments for COVID‐19.
Controlled Doping of Electrocatalysts through Engineering Impurities
Authors: Kim Se‐Ho , Yoo Su‐Hyun , Shin Sangyong , El‐Zoka Ayman A. , Kasian Olga , Lim Joohyun , Jeong Jiwon , Scheu Christina , Neugebauer Jörg , Lee Hyunjoo , Todorova Mira , Gault Baptiste
Published: May 2022

Fuel cells recombine water from H2 and O2 thereby can power, for example, cars or houses with no direct carbon emission. In anion‐exchange membrane fuel cells (AEMFCs), to reach high power densities, operating at high pH is an alternative to using large volumes of noble metals catalysts at the cathode, where the oxygen‐reduction reaction occurs. However, the sluggish kinetics of the hydrogen‐oxidation reaction (HOR) hinders upscaling despite promising catalysts. Here, the authors observe an unexpected ingress of B into Pd nanocatalysts synthesized by wet‐chemistry, gaining control over this B‐doping, and report on its influence on the HOR activity in alkaline conditions. They rationalize their findings using ab initio calculations of both H‐ and OH‐adsorption on B‐doped Pd. Using this “impurity engineering” approach, they thus design Pt‐free catalysts as required in electrochemical energy conversion devices, for example, next generations of AEMFCs, that satisfy the economic and environmental constraints, that is, reasonable operating costs and long‐term stability, to enable the “hydrogen economy.”
Recyclable, Healable, and Tough Ionogels Insensitive to Crack Propagation
Authors: Li Weizheng , Li Lingling , Zheng Sijie , Liu Ziyang , Zou Xiuyang , Sun Zhe , Guo Jiangna , Yan Feng
Published: May 2022

Most gels and elastomers introduce sacrificial bonds in the covalent network to dissipate energy. However, long‐term cyclic loading caused irreversible fatigue damage and crack propagation cannot be prevented. Furthermore, because of the irreversible covalent crosslinked networks, it is a huge challenge to implement reversible mechanical interlocking and reorganize the polymer segments to realize the recycling and reuse of ionogels. Here, covalent crosslinking of host materials is replaced with entanglement. The entangled microdomains are used as physical crosslinking while introducing reversible bond interactions. The interpenetrating, entangled, and elastic microdomains of linear segments and covalent‐network microspheres provide mechanical stability, eliminate stress concentration at the crack tip under load, and achieve unprecedented tear and fatigue resistance of ionogels in any load direction. Moreover, reversible entanglements and noncovalent interactions can be disentangled and recombined to achieve recycling and mechanical regeneration, and the recyclability of covalent‐network microdomains is realized.
A New Enthalpy of Formation Test Set Designed for Organic Fluorine Containing Compounds
Authors: Si Yitao , Liu Yingzhe , Lai Weipeng , Ma Yiding , Shi Jinwen , Wang Bozhou , Liu Maochang , Yu Tao
Published: May 2022

The deviations of gas phase enthalpy of formation predicted by density functional theory on the fluorine containing system are larger than those on other systems in most cases. Therefore, an enthalpy of formation test set composed of 41 organic fluorine containing compounds is proposed, and in this work it is called OFCC41 test set. Twenty exchange‐correlation functionals are estimated by CCSD(T)/CBS as benchmark. The first part of the results indicates that CAM‐B3LYP, ωB97X, and M06 are the most suitable functionals to predict enthalpies of formation for fluorine containing compounds. The remainder of this work is primarily concerned with diffuse basis sets and size‐dependent effects. Diffuse basis sets ma‐SVP and ma‐TZVP can generally improve the prediction performance. For very small molecules, using ma‐SVP is sufficient while for larger molecules more completed basis sets are demanded. Size‐dependent effect of prediction accuracy on different molecules is revealed by using a simple strategy, that the different sizes of molecules are distinguished with three intervals and given the corresponding mean absolute errors. This study provides a test set designed for organic fluorinated compounds and contributes to the selection of some functionals suitable for fluorine containing system.
Highly Efficient (>9%) Lead‐Free AgBiS2 Colloidal Nanocrystal/Organic Hybrid Solar Cells
Authors: Kim Changjo , Kozakci Irem , Kim Junho , Lee Sang Yeon , Lee Jung‐Yong
Published: May 2022

Environmentally friendly colloidal nanocrystals (NCs) are promising materials for next‐generation solar cells because of their low cost, solution processability, and facile bandgap tunability. Recently, silver bismuth disulfide (AgBiS2) has attracted considerable attention owing to its appreciable power conversion efficiency (PCE) of 6.4%. However, issues such as the low open‐circuit voltage (VOC) compared to the bandgap of the AgBiS2 NCs and the unoptimized energy level structure at the AgBiS2 NC/PTB7 hole‐transporting layer (HTL) interface should be resolved to enhance the performance of solar cells. In this study, a design strategy to obtain efficient energy level structure in AgBiS2 NC/organic hybrid solar cells is proposed. By selecting PBDB‐T‐2F as an HTL with a lower highest occupied molecular orbital level than that of PTB7, the VOC of the device is increased. Furthermore, iodide‐ and thiolate‐passivated AgBiS2 NC surfaces are generated using tetramethylammonium iodide (TMAI) and 2‐mercaptoethanol (2‐ME), which leads to the energy level optimization of NCs for efficient charge extraction. This improves the PCE from 3.3% to 7.1%. In addition, the polymer is replaced with a PBDB‐T‐2F:BTP‐4Cl blend to achieve a higher short‐circuit current density through complementary absorption. Accordingly, an AgBiS2 NC‐based solar cell with a PCE of 9.1% is fabricated.
Multiphysics modeling of proton exchange membrane water electrolysis: From steady to dynamic behavior
Authors: Lin Nan , Feng Shouhua , Wang Jianguo
Published: May 2022

Proton exchange membrane water electrolysis (PEMWE) is currently developed for the design of mature industrial‐scale manufactures with commercialization. It needs reducing hydrogen production cost by lowering material cost and increasing operating current density. In engineering perspectives, the study of electrolytic performance during dynamic operation is crucial for PEMWE system management and process control. However, there is few multiphysics models of PEMWE considering transient behavior. The one‐dimensional (1D) comprehensive dynamic multiphysics model allows to explore temporal transport phenomena in the PEMWE, and predict electrolytic performance. The 1D model is endorsed by the spatially lumped model from the literature. Changing values of structural and physical properties of porous transport layers (PTLs) and catalyst layers (CLs) allows the observation of their effects on the electrolytic performance and transport phenomena in two‐phase flow regime. It suggests that the appropriate PTL properties, and CL fabrication method can lower the cost and remain high electrolytic performance.
A model of bubble coalescence in the presence of a nonionic surfactant with a low bubble approach velocity
Authors: Wang Yuelin , Zhang Huahai , Wang Tiefeng
Published: May 2022

A bubble coalescence model for a solution with a nonionic surfactant and with a low bubble approach velocity was developed, in which the mechanism of how coalescence is hindered by Marangoni stress was quantitatively analyzed. The bubble coalescence time calculated for ethanol–water and MIBC–water systems were in good agreement with experimental data. At low surfactant concentrations, the Marangoni stress and bubble coalescence time increased with bulk concentration increase. Conversely, in the high concentration range, the Marangoni stress and coalescence time decreased with bulk concentration. Numerical results showed that the nonlinear relationship between coalescence time and surfactant concentration is determined by the mass transport flux between the film and its interface, which tends to diminish the spatial concentration variation of the interface, that is, it acts as a “damper.” This damping effect increases with increased surfactant concentration, therefore decreasing the coalescence time at high concentrations.
Periostin as a biomarker in chronic rhinosinusitis: A contemporary systematic review
Authors: Danielides Gerasimos , Lygeros Spyridon , Kanakis Menelaos , Naxakis Stephanos
Published: May 2022

Background

The role of periostin, a matricellular protein encoded by the POSTN gene, in chronic rhinosinusitis with nasal polyposis (CRSwNP) is reviewed. Periostin is considered a potential biomarker of endotype and may be useful for evaluating response to treatment.

Methods

Search terms in PubMed and Web of Science (1990–March 2022) included: ((periostin) OR (POSTN)) AND ((sinusitis) OR (nasal polyp) OR (CRSwNP) OR (CRS). The primary outcomes were differences in tissue, serum, and nasal lavage between CRSwNP and CRS without NP (CRSsNP) or controls. Associated factors reported to affect periostin expression, data regarding participants’ clinical characteristics, disease endotypes, laboratory methods, and samples’ origin were also pooled. Studies on <10 patients were excluded.

Results

Out of 101 records harvested through database searching, 29 prospective cross‐sectional or case‐control studies were eligible for review and qualitative analysis. Tissue sample origin, concurrent infection, current and past medication, primary or recurrent disease, allergic rhinitis, and smoking status should be considered as confounding factors for periostin levels. Periostin and POSTN messenger RNA (mRNA) levels were consistently and significantly higher in CRSwNP than CRSsNP and controls. Despite the distinctly different inflammation patterns among CRSwNP endotypes, periostin‐related remodeling patterns seemed to be similar.

Conclusion

Tissue and serum periostin levels, and POSTN expression appear elevated in CRSwNP, especially in eosinophilic inflammation, compared to CRSsNP and controls. Disease severity and comorbidities are also reflected in periostin and POSTN values. Carefully designed prospective studies may establish the role of periostin as a biomarker in CRSwNP and allow its incorporation in clinical practice.
Propagation Properties and Application of Radially Polarized Partially Coherent Twisted Vortex Hermite‐Gaussian Schell‐Model Beams
Authors: Pan Keming , Xu Jia , Zeng Zishuai , Zhao Daomu
Published: May 2022

A class of radially polarized partially coherent twisted vortex Hermite‐Gaussian Schell‐model (RPPCTVHGSM) beams is introduced. The analytical propagation formula for the cross‐spectral density matrix of this beam family is derived. It is found the component of the spectral density and the degree of polarization show twist effects upon propagation. Then, such focused beam family's feasibility to accomplish stable 3D optical capture on both low‐ and high‐index particles is theoretically and numerically analyzed. The results show that utilizing the nonzero order RPPCTVHGSM beam has no limit on the refractive index of particles. Compared with the center of the geometric focal plane, real equilibrium points will shift. Finally, the exact offset of the genuine capture point in each direction is obtained by taking the second‐order RPPCTVHGSM beam as an example. The applications of the work are envisioned in material surface processing and tracking mobile military.
Service lifetime prediction of nitrile butadiene rubber gaskets used in plate heat exchangers
Authors: Zanzi Mateus Sousa , de Souza Elias Luiz , Dutra Gabriel Benedet , Paiva Kleber Vieira , Oliveira Jorge Luiz Goes , Cunha Tiago Vieira , Monteiro André Sampaio
Published: May 2022

Gasketed plate heat exchangers are characterized in a usual heat exchanger class. These systems employ elastomeric gaskets as the sealing element. Several conditions lead to oxidation and deterioration of these materials and their properties. In addition, the complex geometry of the gaskets and operation conditions may cause divergence in the expected aging behavior of the rubber. In light of this, this study aims to predict the service lifetime for nitrile butadiene rubber gaskets used in plate heat exchangers based on their geometry under thermo‐oxidative aging. These gaskets were evaluated by means of Shore A hardness, compression set (CS), and indentation modulus profile. Through aging‐sealing tests, an end‐of‐life criteria was determined concerning CS measurements and the service lifetime prediction was obtained by time–temperature superposition and WLF method. Diffusion‐limited oxidation effects were observed at high temperatures in postaging analysis and a non‐Arrhenius behavior was observed at 170°C. The value of 79% CS was obtained as end‐of‐life criteria from 60 to 140°C, ranged from 731 to 80 days, respectively, revealing an activation energy equivalent to 32.3 kJ mol−1. These results might support the maintenance planning control of gasketed plate heat exchangers.
Stepwise N‐Methylation of Ruthenium and Cobalt 5,15‐Diazaporphyrins: Post‐Functionalization of Porphyrinoid Catalysts
Authors: Nishijo Mayu , Mori Shiho , Nishimura Tsubasa , Shinokubo Hiroshi , Miyake Yoshihiro
Published: May 2022

Post‐functionalization of porphyrinoid catalysts provides a powerful tool for fine‐tuning their electronic structure. We have succeeded in the stepwise methylation of the peripheral nitrogen atoms in ruthenium and cobalt 5,15‐diazaporphyrins. The axial coordination of an anion to the metal center accelerates the second methylation through charge neutralization. N‐Methylation of the diazaporphyrin complexes effectively controls their electron deficiency, Lewis acidity, and catalytic activity.
Determination of meloxicam in human plasma by ultra‐high‐performance liquid chromatography–tandem mass spectrometry and its application in a pharmacokinetic study
Authors: Zhang Siyao , Chen Shutong , Song Yujing , Xin Ying , Cui Ying , Qin Feng
Published: May 2022

A rapid, selective and sensitive ultra‐high‐performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS) method was developed to detect meloxicam in human plasma. A triple quadrupole tandem mass spectrometer equipped with an electrospray ionization source was used in positive ion mode. Protein precipitation with acetonitrile was used for sample preparation. Meloxicam and 13C6‐meloxicam internal standard were analyzed on an Acquity CSH C18 column with a mobile phase of acetonitrile and water in 0.1% formic acid using a gradient program for separation. The retention time of meloxicam was 1.1 min and the total run time was only 2.0 min. Detection was performed in multiple reaction monitoring mode using an electrospray ionization source with optimized mass spectrometry parameters. The calibration curves were linear in the range 10.0–3.00 × 103 ng/ml (r ≥ 0.99). The within‐run and between‐run RSDs were ≤14.8%. The within‐run and between‐run REs ranged from −4.6 to 10.7%. There was no significant matrix effect, and the recovery rate was high. This method was fully validated, including reinjection reproducibility in human plasma. The method was applied to the pharmacokinetic study. All of the incurred sample reanalysis methods met the criteria.
The Lasegue test: Defining its specificity and sensitivity based on geometry
Authors: Asan Ziya
Published: May 2022

The Lasegue test ‐also known as the straight leg raise test‐, used for diagnostic purposes in cases of lumbar disc herniation can be explained by geometrical rules. This study aimed to describe the relationship between the apical and basal size of the herniated disc and the Lasegue test, and to describe the specificity and sensitivity of the herniated disc as a function of its height, location, and size. The study evaluated cases diagnosed with lumbar disc herniation with available MRI scans and Lasegue test results. The radix length to the foramen was calculated by recording the apical length and the base length of the herniated disc. The level and apical direction of the herniated discs were also recorded to determine the specificity and sensitivity of the test. Data from a total of 865 cases were analyzed. The apical length of the herniated disc was the most critical criterion for determining the Lasegue test. The Lasegue test is most sensitive and specific in lateral herniated discs at the level of L4‐5. The specificity and sensitivity are decreased in L3‐4, migrated, and sequestered disc herniations. In these cases, false‐negative results may occur. Sensitivity decreases in the median and paramedian herniated discs. Compression of the sciatic nerve reduces herniated disc straightness. The Lasegue test is a test that can be defined according to the rules of geometry. Knowing the factors that decrease specificity and sensitivity and cause false positive/negative results will facilitate correct diagnosis.
Butterflies teach beautiful lessons about leadership
Authors: Hodges Dawn Z.
Published: May 2022

I have lived an hour away from Callaway Gardens in Georgia for over 20 years now. I've driven past the gates numerous times, but never stopped.
Did court dismiss student's Title IX claim?
Authors: Lyerly Eric
Published: May 2022

A University of Wisconsin student, “Jane Doe,” was allegedly raped by a UW football player. Doe reported the alleged assault to the university, which investigated the incident and found that the football player had sexually assaulted Doe. The university then expelled the football player.
Bowie State AD finds satisfaction in reinvention
Authors: Elfman Lois
Published: May 2022

Clyde Doughty, Jr. had one of the longest runs in college sports. He arrived at New York Institute of Technology as a student‐athlete in 1976 and didn't leave until August 2014 when he was called into human resources and told that a business decision had been made to sever his working relationship with the school. At that time, he had worked at NYIT since college graduation in 1980 — subsequently earning master's degrees in business administration and human resources — and had been the athletics director for 26 years.
A New C22‐Quassinoid with Anti‐Pancreatic Adenocarcinoma Activity from Seeds of Brucea javanica
Authors: Yang Cheng‐Bin , Lu Si‐Nan , Lu Cai , Xu Ming‐Ming , Duan Jin‐Ao , Che Chun‐Tao , Zhou Junfei , Zhao Ming
Published: May 2022

An undescribed C22‐quassinoid named sergeolide A (1) and fifteen known quassinoids (2–16) were obtained from the seeds of Brucea javanica (Simaroubaceae). All chemical structures were established based on spectroscopic data and X‐ray diffraction analysis. Sergeolide A (1) is the first example of a naturally occurring C22‐quassinoid bearing a butenolide group fused the A ring of the bruceolide skeleton from Brucea genus. And this is the first report of the NMR data for desmethyl‐bruceines B (2) and C (3) and the crystal structure for bruceolide (11). In addition, all isolates were evaluated for their anti‐pancreatic adenocarcinoma activity by measuring the growth inhibitory of the MIA PaCa‐2 cell lines. Consequently, compounds 1, 7–10, and 12–16 exhibited potent anti‐pancreatic cancer activity in vitro (IC50=0.054∼0.357 μM).
Operational Performance of a Thermosiphon Reboiler under Foaming Conditions
Authors: Strodtmann Laura , Tartler Elisabeth , Jasch Katharina , Scholl Stephan
Published: May 2022

The evaporation of aqueous solutions with varying surfactant concentrations was investigated with regard to foam formation and performance impairment of the reboiler. Foam formation was induced by partial evaporation in the reboiler and increased with rising driving temperature difference and decreasing operating pressure. Compared to the evaporation of pure water, the addition of surfactants resulted in a reduction in circulation velocity at higher heat fluxes. Temperature profiles in the reboiler tube and area‐averaged heat transfer coefficients were determined to characterize the thermal performance. Only at the lowest surfactant concentration a slight decrease in heat transfer was observed.
Fabrication of Sectionally Permeable Components with Curved Surface by Laser‐Beam Powder‐Bed Fusion
Authors: Xie Dongxu , Fränkle Bernd , Klahn Christoph , Dittmeyer Roland
Published: May 2022

Devices in process engineering often include permeable components. As shown in our recent work for planar components, laser‐beam powder bed fusion offers the opportunity to integrate permeable sections into complex monolithic metal parts in one go. This paper extends the approach to components with curved surfaces. Different scan strategies were investigated for their effects on surface morphology and permeability of tubular samples. It was found that in order to ensure consistent properties of a permeable tube, different starting points or rotation of the scan vectors have to be used.