bluuebunny/crossref_metadata_2025 huggingface dataset:
Direct oral anticoagulants (DOACs): From the laboratory point of view
Authors: Margetić Sandra , Goreta Sandra Šupraha , Ćelap Ivana , Razum Marija
Published: October 2022

Direct oral anticoagulants (DOACs) represent a new generation of drugs that have been increasingly used in the prevention and treatment of thromboembolic states. According to the mechanism of anticoagulant action, DOACs are divided into two groups: direct inhibitors of thrombin (dabigatran) and direct inhibitors of activated factor X (FXa) (rivaroxaban, apixaban, edoxaban, betrixaban). Compared to the vitamin K antagonists, DOACs are superior in terms of onset of action, pharmacokinetic and pharmacodynamics properties and fixed daily dose without the need for routine coagulation monitoring. Despite these advantages, there are clinical conditions in which laboratory measurement of DOACs should be performed. Although DOACs have an impact on screening haemostasis assays (prothrombin time, PT; activated partial thromboplastin time, aPTT; and thrombin time, TT), these tests are not appropriate for quantifying drug levels. Therefore, specific quantitative methods (LC-MS/MS as a gold standard method for all DOACs, coagulometric and chromogenic assays for dabigatran, and chromogenic anti-Xa assays with drug-specific calibrators for inhibitors of FXa) should only be used for determination of DOACs concentration. The aim of this review is to present all aspects of laboratory assessment of DOACs, including pre-analytical, analytical and post-analytical factors in the overall testing process with a special accent on the available specific quantitative methods for measurement of DOACs in circulation.
The impact of the COVID-19 pandemic on the personal finance - a comparative analysis of Poles and Slovaks
Authors: Waliszewski Krzysztof
Published: October 2022

The COVID-19 pandemic, due to its prevalence, has affected all spheres of socio-economic life, in particular household finances. The aim of the article is to present the impact of the pandemic on the financial situation of Poles and Slovaks who use robo-advisory services, including their financial behaviour and investments. The methodology of the article involves literature analysis, statistical data and the author’s own empirical survey. The empirical study aims to verify the research hypothesis: the COVID-19 pandemic influenced the personal finances of Poles and Slovaks who use robo-advice, although this impact was not the same in all areas of personal finance, nor in relation to investment plans after the pandemic. During the pandemic, most of the respondents had lower expenses, but in the future more than half of the respondents did not plan to change the amount of their expenses. Most of the surveyed people increased their savings during the pandemic. Poles more often admitted that they invested more during the pandemic, while more Slovaks than Poles invested the same amount during the pandemic. On the other hand, the Slovak respondents declared that after the pandemic they intend to invest greater sums than Poles indicated.
Morphological and Molecular Characterization of Tylenchorhynchus clarus Allen, 1955 and T. zeae Sethi & Swarup, 1968 (Rhabditida: Telotylenchidae) from Iraq
Authors: Jumaah Ahmed Malik , Azimi Sedighe
Published: October 2022

During a survey on the biodiversity of plant-parasitic nematodes in Misan province (southeast Iraq), Tylenchorhynchus clarus and T. zeae were discovered around the rhizosphere of sugarcane and pumpkin, respectively. The morphological and morphometric data were provided for the recovered species. The morphological characters of both populations are in agreement with the type populations and other populations of them. To the best of our knowledge, this is the first report of these two species from Iraq, and a first report of the association of T. zeae with pumpkin. Molecular phylogenetic analyses of the Iraqi populations of T. clarus and T. zeae using the D2–D3 expansion segments of 28S rDNA and internal transcribed spacer (ITS) rDNA sequences using Bayesian inference (BI), showed they form maximally supported clades with other sequences of both species.
Lysenko Lives?
Authors: DeJong Lambert William
Published: October 2022

When Trofim D. Lysenko took control of biology in the Soviet Union, The New York Times explained it would be “just as if we had to accept Republican or Democratic dictation in scientific reasoning, depending upon which of the two major parties happens to be in power” (New York Times 1948: E6). It was 1948 -- the year of the Berlin Airlift, communist coup in Czechoslovakia, founding of Israel and launch of the Marshall Plan; the start of the Cold War. At a session of the Lenin AllUnion Academy of Agricultural Sciences in Moscow Lysenko declared genetics was a fascist science practiced by worshippers of Wall Street. The “gene theory” had provided the rationale for racism, colonization and the exploitation of the working class. With the words--“The Central Committee of the Party has examined my report and approved it”-- Lysenko launched a purge of genetics that would be termed
Türkiye’de Duran Varlık Yatırımlarının Firmaya Özgü ve Makroekonomik Belirleyicileri
Authors: AÇIKGÖZ Türker , SEZGİN ALP Özge
Published: October 2022

Bu çalışmada, Türkiye'deki duran varlık yatırımlarının firmaya özgü ve makroekonomik belirleyicileri araştırılmıştır. Bu bağlamda araştırma dört farklı işletme ölçeği temelinde; mikro, küçük, orta ve büyük işletmeler olarak gerçekleştirilmiştir. Araştırmada Türkiye Cumhuriyet Merkez Bankası tarafından raporlanan reel sektör bilançoları kullanılmış ve dört farklı işletme ölçeği için dört farklı panel veri regresyon analizi gerçekleştirilmiştir. Bu çalışmanın bulguları duran varlık yatırımlarının, tüm işletme ölçeklerinde, likidite ve karlılık ile anlamlı ve ters yönlü ilişkisi olduğunu göstermektedir. Sermaye yapısı değişkeninde ise mikro ve küçük ölçekli işletmelerde anlamlı bir ilişki görülemezken orta ve görülmüştür. Makroekonomik değişkenlerde ise enflasyondaki artışın büyük ölçekli firmaların uzun dönem varlıklara yatırımını artırdığı, fakat mikro ölçekli firmalarda tam tersi bir etkiye neden olduğu görülmüştür.
Tahvil ve Hisse Senedi Piyasaları Arasında Zamanla Değişen Nedensellik İlişkileri: Hatemi-J Dinamik Nedensellik Testi Bulguları
Authors: CAMGÖZ Mevlüt
Published: October 2022

İktisadi gelişmeler ve risk faktörlerindeki belirsizlik durumu varlık sınıfları arasındaki ilişkileri zamana bağlı olarak değiştirebilmektedir. Finans teorisinde merkezi bir konumda olan tahvil ve hisse senedi piyasaları arasındaki nedensellik ilişkilerine odaklanan bu çalışma, tahvil piyasasından hisse senedi piyasasına doğru simetrik ve asimetrik nedensellik ilişkisinin olup olmadığını ve eğer varsa bu ilişkinin zamana bağlı olarak değişip değişmediğini ortaya koymayı amaçlamaktadır. Analiz yöntemi olarak Hatemi-J (2021) tarafından geliştirilen dinamik simetrik ve asimetrik nedensellik testleri benimsenmiştir. Analiz Ocak 1980 ile Nisan 2022 tarihleri arasında gerçekleştirilmiş ve ABD (Amerika Birleşik Devletleri) tahvil ve hisse senedi piyasası incelenmiştir. Dinamik simetrik ve asimetrik nedensellik testi bulguları tahvil piyasasından hisse senedi piyasasına doğru olan nedensellik ilişkisinin zamana bağlı olarak değiştiğini göstermektedir. Yani tahvil piyasası ile hisse senedi piyasası arasındaki nedensellik ilişkilerinde yapısal değişimler ve zaman bağımlılığı mevcuttur. Bu durumda statik modellerin riskten korunma, çeşitlendirme ve varlık dağılımı gibi kararlarda taraflı yönlendirme yapabileceği ortaya konulmuş olmaktadır.
Plan estratégico y prospectivo del sector de frutas frescas en el Valle del Cauca 2033
Authors: Caicedo Asprilla Henry , Vargas Calderón Diego Fernando , Rosero Giraldo José Manuel , Durán Peralta Julián , Jaramillo Cruz Carlos Alberto , Amórtegui Yuliana , Cruz Aguilar Pedro León , Ríos Obando José Fabian , Vargas García Lina Marcela , Tegethoff Thomas Manfred
Published: October 2022

En el presente libro se presentan tres estudios relacionados con el sector de frutas frescas en el Valle del Cauca, el primero de ellos es un estudio de referenciamiento competitivo, el segundo es un estudio de inteligencia económica (vigilancia tecnológica y análisis de tendencia) y, por último, se define el modelo y los caminos de cambio del sector tomando como horizonte temporal el año 2033. Para estos tres estudios se toman como referencia cuatro cadenas productivas priorizadas; banano, piña, aguacate y cacao. Buena parte de los insumos utilizados en el libro son producto de la realización del Índice de medición y monitoreo de la competitividad del sector de frutas frescas, el cual fue desarrollado teniendo en cuenta una encuesta realizada a 354 actores del sector de frutas frescas del departamento. Para el procesamiento y análisis de la información obtenida se utilizaron metodologías como árbol de problemas, benchmarking, matriz Vester, para determinar el mapa de actores, las principales problemáticas del sector y el referenciamiento competitivo del mismo. Por otro lado, para la construcción del índice se utilizó un análisis de componentes principales debido a la gran cantidad de variables medidas, mientras que en el estudio prospectivo fue necesaria la metodología Mic-Mac. Algunas de las conclusiones del estudio apuntan a la existencia una brecha tecnológica entre la cadena productiva y los actores paralelos del sector, quien son los principales encargados de realizar las investigaciones y los procesos de transferencia de conocimientos. Se espera que este documento pueda contribuir al fortalecimiento del sistema de Competitividad, Ciencia, Tecnología e Innovación (C&CTI) y el desarrollo del Valle del Cauca, que permita la toma de decisiones inteligentes que transformen a la región en una economía del conocimiento.
The Influence of Financial Knowledge on Financial Behavior and Financial Satisfaction on Pelita Indonesia Students
Authors: Panjaitan Harry Patuan , Renaldo Nicholas , Suyono Suyono
Published: October 2022

The 2020 pandemic situation caused more than 60 percent of dissatisfaction with the survey results to the current financial situation. From the same small survey, it was found 34 percent of respondents showed poor financial habits. This study aims to determine the effect of Financial Knowledge on Financial Behavior and Financial Satisfaction. The sample in this study was 246 people using purposive and convenience sampling techniques. Data processing using path analysis with a Bayesian approach. The results showed that there was a significant influence of Financial Knowledge on Financial Behavior, Financial Knowledge on Financial Satisfaction, and Financial Behavior on Financial Satisfaction. Improved Financial Knowledge, both directly and indirectly, will greatly impact on Financial Satisfaction and really needs to be improved. Central Bank can provide financial knowledge supplies to lecturers of certain subjects so that it can be passed on to students.
Keywords—Bayesian Approach; Behavior; Knowledge; Satisfaction
Underlying Internationalization Process Theories for Small and Medium Enterprises (SMEs): A Systematic Literature Review and Classification of Research Streams
Authors: Chaldun Evy Rachmawati , Yudoko Gatot , Prasetio Eko Agus
Published: October 2022

Studies on the internationalization process of SMEs have fascinated the attention of researchers around the world. The dynamics in the internationalization process of SMEs have attracted researchers' interest in analyzing the behavior and the factors that influence it with various theoretical approaches to contribute to the development of international business studies. This paper intended to provide an overview of the various theories applied in investigating SMEs' internationalization process. The review was conducted on 100 journal articles between 2013 and 2020. The investigation results show that 17 different theories have been identified in the internationalization process of SMEs and we classified them into five streams. Based on our findings, from those 17 theories, the five primary published theories in order are (1) Uppsala theory, (2) Network theory, (3) Resource-based theory, (4) international entrepreneurship theory, and (5) institutional theory. This study also provides suggestions and implications for future research.
Keywords— Internationalization process; Internationalization SME theory; Small and Medium Enterprises (SMEs)
Car Sharing in Marketing
Authors: Wibowo Alexander Joseph Ibnu , Sumarwan Ujang , Suharjo Budi , Simanjuntak Megawati
Published: October 2022

The objective of this article is to explore several studies on Car Sharing (CS) in the marketing discipline. A total of 1,251 articles was collected from several journals in the Q1 Schimago category. Of these number 165 articles were chosen for research goals. A detailed investigation reduced this amount to 50 articles. The content analysis technique is applied by examining some key aspects, such as theme, authorship, research type, scope, and research design. The results of this study show that top-class journals have not published many articles about CS in the marketing discipline, but this does show an upward trend. Most articles are empirical papers. In general, the findings show a shift in the focus of CS studies in the marketing discipline over time.
Keywords—Online transportation; Sharing economy; Car sharing; Marketing; Content analysis
الحذف على التدرج في القرآن الكريم دراسة نقدية دلالية
Authors: Taha Hasan Ali
Published: October 2022

الحذف هو ظاهرة من الظواهر اللغوية التي تشترك فيها اللغات الانسانية، وتظهر هذه الظاهرة في بعض اللغات أكثر من غيرها كما نراها في لغتنا العربية التي دائما تميل إلى الإيجاز والاختصار الذي يكسب العبارة قوة وثراءً في المعنى ويبعدها عن الثقل، بل عدَّ ابن جني هذه الظاهرة من شجاعة العربية التي يكون الحذف فيها بالحركة والكلمة والجملة والكلام وكل ذلك بدليل يدل على المحذوف، وللحذف في العربية أنواع منها حذف الاقتطاع، والاكتفاء، والاحتباك والاختزال، ومن أنواع الحذف التي ذكرها النحاة حذف التدرج وهو موضوع بحثنا ، وقد ذكر هذا النوع جملة من النحاة ونسبه ابن جني إلى أبي الحسن الأخفش وتابعه على ذلك العلماء من بعده وعدَّه ابن جني من ملاطفة الصنعة بَيْدَ أن النحاة قد اوجزوا الكلام فيه تنظيرا وتطبيقا، وكان عنوان البحث: (الحذف على التدرج في القرآن الكريم دراسة نقدية دلالية) وقد قسمت البحث على مقدمة وتمهيد  وأربعة مباحث وخاتمة، ذكرت في التمهيد مفهوم الحذف في اللغة والاصطلاح، ومفهوم الحذف على التدرج وموقف النحويين منه.
والمبحث الأول كان بعنوان: المفعول به الذي اقيم المضاف إليه مقامه، والثاني: ضمير الصفة وهو من التوابع، والثالث: ما حذف فيه مضافان، والرابع: ما حذف فيه أكثر من مضافين، ثم خاتمة ذكرت فيها أهم النتائج التي توصلت إليها.
التعليم الإلكتروني في ظلّ انتشار جائحة كورونا – المنجزات والتحديات
Authors: Talib Khawlah.M.
Published: October 2022

الهدف من هذه الدراسة  كشف التغيرات المفاجئة على التعلم الإلكتروني كما أننا نعلم أنّ ملف التعلم الالكتروني  لم يكن ولوقت قريب ضمن الاهتمامات الأولوية لإصلاح وتطوير المؤسسات التعليمية، لذا نهدف في الدرجة الأولى إلى إظهار سمات التعليم الإلكتروني لإدارة الأزمة بفاعلية تمكن المتعلمين من تلقي المعلومات والتفاعل مع العملية بنجاح أكبر، وتحديد المشاكل التي تقف حاجزاً دون الوصول إلى الأهداف المطلوبة، وما ايجابيات هذا النوع من التعليم.
Features of urban and rural settlement systems at the present stage
Authors: Быстрова Татьяна Юрьевна , Мазаев Григорий Васильевич
Published: October 2022

В статье рассматриваются особенности городской и сельской систем расселения, показана разница их типов сложности, уровней стратифицированности и возможностей пространственного развития. Будучи неучтенными в полной мере, эти особенности не позволяют специалистам создать адекватные модели сельской системы расселения и препятствуют принятию эффективных решений по усилению устойчивости села. В статье выявлены типичные недочеты и перспективные направления исследований сельской системы расселения, показаны ее качественные отличия от городской системы расселения. Все это способно в дальнейшем помочь в практических действиях по усилению устойчивости сельского расселения в России.

The article discusses the features of urban and rural settlement systems, shows the difference in their types of complexity, levels of stratification and opportunities for spatial development. Being not fully taken into account, these features do not allow specialists to create adequate models of the rural settlement system and hinder decisions to strengthen the sustainability of the country side. The article reveals typical shortcomings and perspective research areas of the rural settlement system, shows its qualitative differences from the urban settlement system. All this points can further help in practical actions to strengthen the sustainability of rural settlement in Russia.
The metaphorical form of lotus in the design of public buildings
Authors: Нунех Антван , Макарова Татьяна Львовна
Published: October 2022

В статье проводится иконографический анализ архитектурных работ, принимающих природный элемент лотос как символ азиатской культуры. В результате исследования выявлены факторы, которые играют значимую роль в семантической дифференциации представленных архитектурных объектов и в повышении уникальности дизайна каждого здания.

This article provides an iconographic analysis of architectural works that take the natural element lotus as a symbol of Asian culture. As a result of the study, factors were identified that play a significant role in the semantic differentiation of the presented architectural objects and in increasing the uniqueness of the design of each building.
СОВРЕМЕННЫЕ ТЕНДЕНЦИИ ФОРМИРОВАНИЯ АССОРТИМЕНТА БЕЗГЛЮТЕНОВЫХ МУЧНЫХ КОНДИТЕРСКИХ ИЗДЕЛИЙ
Authors: Козубаева Людмила Алексеевна , Кузьмина Светлана Сергеевна
Published: October 2022

Питание людей, больных целиакией, ограничено непременным требованием отсутствия в рационе глютенсодержащих продуктов, в том числе традиционных мучных кондитерских изделий. Однако маркетинговые исследования свидетельствуют об интересе потребителей к этой группе сладких продуктов. При этом о заболевании целиакия и аглютеновых продуктах имеют представление только около 30 % опрошенных. В статье обобщены современные тенденции формирования ассортимента безглютеновых мучных кондитерских изделий, которые базируются на использовании разнообразных видов муки, не имеющих в составе глютена ‒ клейковинобразующих белков (рисового, кукурузного, гречневого, льняного, конопляного и других), а также на приготовлении двух- и многокомпонентных смесей из них. Помимо аглютеновой муки в рецептуре изделий могут присутствовать высокобелковые соевые изоляты и концентраты, изоляты белков гороха, люпина, казеинаты, концентраты сывороточных белков и др., гидроколлиоды (ксантан, гуаровая камедь, различные виды натуральных и модифицированных крахмалов), а также эмульгаторы, разрыхлители, вкусовые ингредиенты. В качестве обогащающих добавок в рецептуре используются плодово-ягодные и овощные порошки. Расширение сегмента мучных кондитерских изделий без глютена направлено на поиск компромисса между качеством, физиологической ценностью и потребительским предпочтением. Мука из семян и орехов способствует повышению пищевой ценности за счет широкого спектра минеральных веществ и витаминов. Обладая высокой антиоксидантной и физиологической активностью, мука кедрового ореха повышает потребительскую привлекательность готового продукта. Замена 30 % гречневой муки на квиноа позволяет нивелировать выраженный вкус муки и получить печенье с приятным ароматом лесных орехов. Безглютеновые изделия представлены разными видами печенья, кексами, вафлями, бисквитным полуфабрикатом, композитными смесями для производства кексов.
РАЗРАБОТКА РЕЦЕПТУРЫ МУЧНЫХ КОНДИТЕРСКИХ ИЗДЕ-ЛИЙ ФУНКЦИОНАЛЬНОГО НАЗНАЧЕНИЯ С ДОБАВЛЕНИЕМ РАСТИТЕЛЬНЫХ КОМПОНЕНТОВ: КОНОПЛЯНОЙ МУКИ И ПОРОШКА ЯГОД АСАИ
Authors: Макарова Виктория Николаевна , Пчелинцева Ольга Николаевна , Бочкарёва Зенфира Альбертовна
Published: October 2022

Одним из недостатков кондитерских изделий является практически полное отсутствие биологически активных веществ. В связи с этим химический состав изделий нуждается в увеличении пищевых волокон и снижении энергетической ценности. Приоритетным направлением развития кондитерской отрасли является поиск новых растительных источников биологически активных веществ для обеспечения населения биологически полноценными продуктами питания, отвечающими требованиям физиологических норм организма человека. В данных исследованиях была разработана рецептура мучных кондитерских изделий функционального назначения с внесением различного процентного содержания от общей массы муки конопляной муки и порошка ягод асаи. Количество добавляемого сырья составило: в образце № 1 – заменяли 15 % пшеничной муки на конопляную и добавляли 5 % порошка асаи, в образце № 2 – заменяли 25 % пшеничной муки на конопляную и добавляли 7 % порошка асаи, в образце № 3 – заменяли 35 % пшеничной муки на конопляную и добавляли 9 % порошка асаи. По результатам исследований и проведенным расчетам наиболее оптимальным по показателям пищевой и биологической ценности является образец № 2.
ТЕХНОЛОГИЧЕСКИЕ АСПЕКТЫ ПРОИЗВОДСТВА ПРОТЕРТЫХ МАСС БЕЗ САХАРА НА ОСНОВЕ ПЛОДОВОГО И ЯГОДНОГО СЫРЬЯ АЛТАЙСКОГО СОРТИМЕНТА
Authors: Скороспелова Елена Владимировна , Михайлова Оксана Юрьевна , Шелковская Наталья Кирилловна
Published: October 2022

Особенности технологии производства протертых масс без сахара из плодов алтайской селекции, выращенных в лесостепной зоне Алтайского края, не достаточно изучены. Многие вопросы технологии, а также разработка нормативно-технической документации на новый вид продуктов актуальны и имеют научную новизну. Протертая масса из плодов может быть использована как самостоятельный продукт или функциональный наполнитель для продуктов питания.Для приготовления протертых масс без сахара плоды подвергали инспекции, мойке, далее бланшировали, дробили и протирали через сито с диаметром ячеек 0,7-1,5 мм. Полученную массу уваривали, фасовали, пастеризовали при температуре 95°С, герметично укупоривали.Новые виды продуктов консервирования, полученные из жимолости и смородины черной, отличаются высокой кислотностью: 4,15-4,70 % в жимолостных и 3,00-3,40 % в черносмородиновых. Минимальное значение титруемой кислотности отмечено в продуктах из яблок – 1,02-1,14 %. Содержание сахаров в протертых массах колеблется от 6,6 до 11,8 г/100 г. Максимальное значение отмечено в протертых массах из яблок, минимальное – в образце из облепихи сорта Августина. Минимальное содержание полифенолов отмечено в яблочных протертых массах (171-174 мг/100 г), максимальное – в образцах из жимолости (604-830 мг/100 г). В облепиховых протертых массах содержание полифенолов 133-290 мг/100 г, в черносмородиновых 159-567 мг/100 г. Протертые массы без сахара по физико-химическому составу имеют существенные отличия по сортам.Разработаны ТИ и ТУ по производству протертых масс без сахара из плодово-ягодного сырья алтайской селекции.
ВЫДЕЛЕНИЕ, ХАРАКТЕРИСТИКА И ПЕРСПЕКТИВЫ ИСПОЛЬЗОВАНИЯ ПЕПТИДОВ МОЛОЗИВА КОРОВ
Authors: Тихонов Сергей Леонидович , Тихонова Наталья Валерьевна , Данилова Ирина Георгиевна , Ожгихина Анна Сергеевна , Тихонова Мария Сергеевна , Поповских Анжелика Денисовна
Published: October 2022

Несмотря на большие успехи, достигнутые в создании пищевой продукции для профилактики алиментарнозависимых заболеваний, некоторые проблемы сохранения здоровья человека остаются без ответа. Развитие онкологических заболеваний, бактериальных и вирусных инфекций со множественной лекарственной устойчивостью по-прежнему представляет собой угрозу мирового значения. Альтернативой известным лекарственным препаратам и микронутриентам представляются природные биологически активные пептиды, обладающие широким спектром антимикробной, противоопухолевой, и иммуностимулирующей активностями. Цель исследований – выделение, характеристика и оценка перспектив использования пептидов трипсинового и пепсинового гидролизата молозива коров в производстве пищевой продукции специализированного назначения и лекарственных препаратов. Белковые фракции ферментативного гидролизата молозива коров исследовали на масс-спектрометре МАЛДИ-ТОФ, расшифровку проводили с помощью базы данных Mascot, опция Peptide Fingerprint («Matrix Science», США) с использованием базы данных Protein NCBI. В трипсиновом гидролизате молозива коров выделено 7 пептидов, в пепсиновом гидролизате – 9 пептидов. Выделенные пептиды характеризуются различной аминокислотной последовательностью, молекулярной массой и скором, различаются по физиологическим функциям в организме человека. Пептид «Dualspecificityproteinphosphatase» способен акти­визировать иммунныуй ответ, «NCI_CGAP_Brn23 Клонк ДНК Homo sapiens» обеспечивает нормальное развитие центральной нервной системы, пептид «BAMA» способен встраиваться во внешнюю мембрану бактерий, что позволяет его использовать как переносчик грузов в клетки организма для поддержания жизнедеятельности или борьбы с вирусными инфекциями, для подавления опухолевых клеток. Пептид «Nuclearreceptor 2C2-associatedprotein» препятствует возникновению рака. Функции других выделенных пептидов не изучены, что предполагает проведение исследований по оценке их биологической активности. Полученные данные позволяют предположить, что пептиды с доказанной фармакологической активностью после проведения дополнительных доклинических и клинических исследований можно использовать при разработке продуктов питания функциональной направленности и терапевтических средств широкого спектра действия
Clean synthetic strategies to dopamine-based biologically active molecules from lignin: A green path to drug discovery
Authors: Afanasenko Anastasiia , Wu Xianyuan , DeSanti Alessandra , Elgaher Walid , Kany Andreas M. , Shafiei Roya , Schulze Marie-Sophie , Schulz Thomas , Haupenthal Jörg , Hirsch Anna K. H. , Barta Katalin
Published: October 2022

The structural complexity of renewable resources offers remarkable opportunities for the environmentally friendly manufacturing of essential pharmaceuticals, yet this has not been adequately addressed due to the lack of suitable methods. Our here described approach to drug discovery, builds on the innate structural features of the aromatic moiety of lignin to enable green pathways to various classes of biologically active molecules of the core dopamine structure. The catalytic transformations are atom-economic, produce only harmless side-products and use benign reaction media, including tunable deep eutectic solvents for modulating reactivity in challenging cyclization steps. Biological screening and chemical similarity searches identified promising anti-infective, anti-inflammatory, and anticancer activities. The frontrunners show outstanding metabolic stability and in vivo activity against Streptococcus pneumoniae infection, highlighting the power of our strategy.
Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2
Authors: Ramachandran Sarath , Makukhin Nikolai , Haubrich Kevin , Casement Ryan , Nagala Manjula , Lynch Dylan , Testa Andrea , Bruno Elvira , Gitto Rosaria , Ciulli Alessio
Published: October 2022

The Src homology 2 (SH2) domain is present in many proteins that bind to phosphotyrosine (pY) post translational modifications in partner proteins to trigger downstream signalling. Since pY-driven protein-protein interactions can sustain disease, SH2 domains have long been the focus of small-molecule ligand discovery efforts, but have been stymied by the poor drug-like properties of phosphate and its mimetics. Here, we have used structure-based design to target the SH2 domain of the suppressor of cytokine signalling 2 (SOCS2) – the substrate recognition subunit of a Cullin5 RING E3 ligase. Starting from the highly ligand-efficient pY amino acid, a fragment growing approach improved binding affinities in the nanomolar range. During the course optimization campaign, in one of our co-crystal structures we observed serendipitous modification of Cys111 at a flexible variable loop distal from the phosphate binding site. This inspired the rational design of a cysteine-directed electrophilic covalent inhibitor MN551. A prodrug strategy using a pivaloyloxymethyl (POM) protecting group aided cell permeability and its rapid unmasking inside the cell enabled efficient and selective covalent engagement of SOCS2. We qualify MN551 and its masked analogue MN714 as covalent inhibitors of SOCS2, that could find attractive applications as chemical probes to understand the biology of SOCS2 and its CRL5 complex, and as covalent E3 ligase handles in proteolysis targeting chimera (PROTACs) to induce targeted protein degradation. More broadly, this work provides a blueprint for developing and exploiting pY-based small molecules to target other SH2 domains.
Readily Accessible Strained Difunctionalized trans-Cyclooctenes with Fast Click and Release Capabilities
Authors: Sondag Daan , Maartense Luuk , de Jong Heleen , de Kleijne Frank , Bonger Kim , Lowik Dennis , Boltje Thomas , Dommerholt Jan , White Paul , Blanco-Ania Daniel , Rutjes Floris
Published: October 2022

The click reaction between a functionalized trans-cyclooctene (TCO) and a tetrazine is a compelling method for bioorthogonal conjugation in combination with payload releasing capabilities. However, the synthesis of difunctionalized TCOs remains challenging. As a result, these compounds are poorly accessible, which impedes the development of novel applications. In this work, the scalable and accessible synthesis of a new bioorthogonal difunctionalized TCO is reported in only four single selective steps starting from commercially available compounds. The click kinetics and payload release were assessed with various functionalized derivatives and local drug release was shown in a cellular toxicity study.
ReNeGate: Reaction Network Graph Theoretical tool for automated mechanistic studies in computational homogeneous catalysis
Authors: Hashemi Ali , Bougueroua Sana , Gaigeot Marie-Pierre , Pidko Evgeny
Published: October 2022

Exploration of the chemical reaction space of chemical transformations in multicomponent mixtures is a challenge for modern computational protocols. In order to remove expert bias from mechanistic studies and to discover new chemistries, an automated graph-theoretical methodology is proposed to provide mechanistic analysis in catalytic systems. The primary advantage of the presented three-step approach over the existing automated pathways generation methods is the integrated ability to handle multicomponent catalytic systems of arbitrary complexity (mixtures of reactants, catalyst precursors, ligands, additives, and solvent). It is not limited to pre-defined chemical rules, does not require pre-alignment of reaction mixture components consistent with a reaction coordinate and is not agnostic to the chemical nature of transformations. Conformer exploration, Reactive event identification and Reaction network analysis are the main steps taken for understanding the underlying mechanistic pathways in catalytic mixtures given the reaction mixture as the input. Such a methodology allows to comprehensively explore the catalytic systems in realistic conditions for either previously observed or completely unknown reactive events. The expert bias is sought to be removed in either of the steps and chemical intuition is limited to the choice of the thermodynamic constraint imposed by the applicable experimental conditions in terms of threshold energy values for allowed transformations. The capabilities of the proposed methodology have been tested by exploring reactivity of Mn complexes relevant for catalytic hydrogenation chemistry to verify previously postulated activation mechanisms and unravel unexpected reaction channels relevant to rare deactivation events.
SUBJECTIVE NOTES ON LEGAL TERMS
Authors: Тарусина Надежда Николаевна
Published: October 2022

Предлагаются размышления об этической некорректности, психологической дискомфортности либо небрежности, допускаемых российским законодателем при конструировании нормативно-правовых предписаний (при использовании терминов, терминологических конструкций, попытках дефинирования понятий). Образцы подобного рода обнаружены, в силу строго определенных научных интересов автора, в законодательстве социальной сферы - в широком ее значении (семейном, трудовом, страховом, медицинском). Среди прочего обращается внимание на своеобразные проявления при терминологическом обеспечении текстов гендерных стереотипов и неточностей.

The article offers reflections on ethical incorrectness, psychological discomfort or negligence allowed by the Russian legislator in the construction of legal regulations (when using terms, terminological constructions, attempts to define concepts). Samples of this kind were found, due to the strictly defined scientific interests of the author, in the legislation of the social sphere -in its broad meaning (family, labor, insurance, medical). Among other things, attention is drawn to the peculiar manifestations of gender stereotypes and inaccuracies in the terminological provision of texts.
INVESTIGATIVE JUDGE: ORIGINS AND PROSPECTS OF IMPLEMENTATION INTO THE LEGISLATIVE SYSTEM OF THE RUSSIAN FEDERATION
Authors: Любовенко Елена Сергеевна
Published: October 2022

Предлагается вернуться во времена великих преобразований второй половины XIX в. в Российской империи и подвергнуть анализу одну из интереснейших реформ - реформу следствия, изучить мнения уважаемых членов пореформенной комиссии. Безусловно, мы изучаем историю, чтобы использовать этот опыт для совершенствования современного законодательства.

It is proposed to return to the times of great transformations of the second half of the 19th century. in the Russian Empire and analyze one of the most interesting reforms -the reform of the investigation, to study the opinions of respected members of the post-reform commission. Of course, we are studying history in order to use this experience to improve modern legislation.
Arap Tiyatrosundan Karşılaştırmalı İki Şehrâzâd
Authors: TOLAN Muhammet Bilal
Published: October 2022

Binbir Gece Masalları, bir çerçeve hikâye ve onun etrafında oluşturulan masallardan meydana gelen bir masal külliyatıdır. Kökeni itibariyle Doğu edebiyatını temsil eden bu masallar, Batı dillerine çevrilmesiyle birlikte orada da meşhur olmuş ve böylece Dünya edebiyatında önemli bir yer işgal etmiştir. Bu masallar gerek Doğu’da ve gerekse Batı’da birçok edebiyatçıyı etkilemiş ve onlara ilham kaynağı olmuştur. Birçok edebi eserin, doğrudan veya dolaylı olarak bu külliyattan beslendiği görülür. Modern Arap Edebiyatının önemli ve üretken iki yazarı Tevfîk el-Hakîm ve Ali Ahmed Bâkesîr de bu masallardan esinlenerek birer tiyatro eseri yazmışlardır. el-Hakîm, yetmişi aşkın tiyatro eserinden biri olan Şehrâzâd eserinde binbirinci geceden sonra yaşananları bir kurgu ile okuyucuya sunmuştur. Bu eserde Şehrâzâd’ın anlattığı hikâyelerle Şehriyâr bambaşka bir insan olmuştur. Daha önce her türlü maddi zevki tatmış olan bu kral, artık bilgiyi aramakta ve mekânın sınırlarından kurtulmak istemektedir. Şairliği ve romancılığının yanı sıra Arap tiyatrosuna da önemli katkıları olan Bâkesîr ise, kırkın üzerinde tiyatro eseri yazmıştır. O, bu eserlerden biri olan Sırru Şehrâzâd adlı eserini Binbir Gece Masalları’nın çerçeve hikâyesinden hareketle kaleme almıştır. Yazar eserinde modern bir yorum geliştirerek, kadının sadakatsizliği üzerine kurulan çerçeve hikâyeyi değiştirmiş ve yeni bir kurgu ile ele almıştır. Buna göre Sırru Şehrâzâd adlı eserde Şehriyâr’ın ilk eşi, masum bir karakter olarak canlandırılmış ve olay örgüsü bunun üzerine bina edilmiştir. Bu çalışmada öncelikle orijinal Binbir Gece Masalları hakkında genel bilgiler sunulmuş ardından el-Hakîm ve Bâkesîr’in bahsi geçen tiyatro eserleri edebi açıdan incelenmiş, son olarak her iki yazarın eserindeki Şehrâzâd karakteri karşılaştırılmıştır.
Factors associated with quality of life in predialysis chronic kidney disease. Review of literature
Authors:   Pavlov University, Vasilieva I.A.
Published: October 2022

Health-related quality of life (QoL) is one of the main patient-reported outcomes. Monitoring QoL in patients with chronic kidney disease (CKD) can be considered one of the approaches to the implementation of the principles of personalized medicine in clinical nephrology. The review provides a brief description of the questionnaires most used to assess QoL in patients with CKD and summarizes the results of studies of factors related to QoL at predialysis stages. It is customary to distinguish sociodemographic, clinical, and psychological factors associated with health-related QoL. Being female, smoking, low levels of education and income, the presence of coronary heart or cerebrovascular diseases, depression, and anxiety were shown to be associated with a decrease in QoL of patients with predialysis CKD. As for other clinical and socio-demographic factors, the literature data are not so unambiguous. Thus, several studies have demonstrated that a decrease in glomerular filtration rate, albumin and hemoglobin levels, the presence of diabetes, and an increase in age and creatinine level negatively affect the parameters of the physical component of QoL. At the same time, a significant number of studies have not found a relationship between these variables and the parameters of the psychosocial component of QoL, which is explained by the dependence of this QoL component primarily on the characteristics of the emotional state and personality. Of the psychological factors associated with QoL in patients with CKD treated conservatively, the attention of researchers was focused mainly on the level of depression. Only a few studies have analyzed other psychological variables (personality traits, coping strategies, effects of psychosocial interventions) related to QoL in patients with predialysis CKD. Identification and systematization of potentially modifiable factors affecting patients’ QoL set the directions for the prevention and correction of reduced QoL
Managing the information and educational environment of an educational institution under the influence of digitalization
Authors: Romanova Ekaterina , Gasanova Renata
Published: October 2022

The book discusses the processes taking place in pedagogical education, analyzes modern approaches, ideas, technologies for the transformation of the management of the information and educational environment of an educational institution under the influence of digitalization. Materials from scientific articles and reports at conferences, dissertation research of authors on the problems of the information and educational environment of the educational institution are presented. It is addressed to teachers, scientists, teachers, graduate students, employees of educational institutions, the general pedagogical community.
TRAVMATİK YAS YAŞAYAN ÜNİVERSİTE ÖĞRENCİLERİNİN SAVUNMA DÜZENEKLERİ, PSİKOLOJİK BELİRTİLERİ VE MMPI KLİNİK ALT BOYUTLARININ ÇEŞİTLİ DEĞİŞKENLER AÇISINDAN İNCELENMESİ
Authors: AVCI Mahsum
Published: October 2022

Bu çalışmanın amacı travmatik yas yaşayan üniversite öğrencilerinin travmatik yas şiddeti, savunma düzenekleri, psikolojik belirtileri, MMPI klinik alt boyutlarının çeşitli değişkenler açısından incelemektir. Cinsiyet, yaşanılan yer, algılanan ekonomik düzey, anne-babanın sağ olup olmama, kaybedilenin kim olduğu, kaybedilenin ölüm nedeni, kayıptan sonra hayatı sonlandırma düşüncesi, kaybedilenin medeni durumu ve kayıptan sonra profesyonel yardım alıp almama değişkenler olarak çalışmaya dâhil edildi. Araştırma grubu travmatik yası olan 15 üniversite öğrencisinden oluşmaktadır. Veri toplama yöntemi olarak, amaçlı örnekleme yöntemlerinden kriter örneklem yöntemi kullanıldı. Verilerin analizinde ise betimsel analizler kullanılmıştır. Verilen analizinde betimsel istatistik, değişkenler arasındaki ilişkiyi incelemek için Spearman korelasyon analizi tekniğinden yararlanılmıştır. Araştırmanın sonuçlarına göre, kızların erkeklere göre MMPI’ın ML alt skalası, Hs boyutu ve D boyutu puanlarının daha yüksek olduğu tespit edilmiştir. Büyük kentte yaşayanların köyde yaşayanlara göre ek skala puanlarının daha yüksek olurken, gelirini üst ve orta-alt olarak algılayanların gelirini orta olarak algılayanlara göre Nevrotik Savunma boyutu puanları daha yüksek olduğu görülmektedir. Annesi sağ olmayanların, Travmatik Yas Ölçeği puanlarında anlamlı bir farklılık tespit edilmiştir. Diğer yandan babanın sağ olup olmama durumları karşılaştırıldığında; Kişilerarası duyarlılık, paranoid düşünceler ve genel semptom indeksi belirtilerinde anlamlı bir farklılık olduğu, babası sağ olanların olmayanlara göre Immature Savunmayı ve Mature Savunmayı daha fazla kullandıkları, babası sağ olan ve olmayanların; MMPI’ın MA boyutu değerlerinde anlamlı bir fark olduğu saptanmıştır. Kardeşini kaybedenlerin babasını ve annesine kaybedenlere göre Immature Savunma boyutu puanları daha yüksek, yakını hastalıktan ölenlerin yakını trafik kazasından ve intihar nedeniyle ölenlere göre Mf boyutu değerleri daha yüksek bulunmuştur. Kayıptan sonra hayatını sonlandırmayı düşünenlerin düşünmeyenlere göre Minnesota Çok Yönlü Kişilik Envanterinin alt boyutu olan MF alt skalası ve PA boyutu puanları ve kayıptan sonra profesyonel yardım alanların almayanlara göre anksiyete puanları daha yüksek bulunmuştur. Diğer yandan kaybedilen kişi evli olan ve bekâr olanların; MMPI’ın Sİ boyutu değerlerinde anlamlı bir fark olduğu saptanmıştır.
BSMI POLYMORPHISM OF VITAMIN D RECEPTOR GENE AND EFFICIENCY OF POST- MENOPAUSAL OSTEOPOROSIS TREATMENT BY IBANDRONIC ACID
Authors: Reznichenko N. , Adunts A.
Published: October 2022

An assessment of genetic factors influence on ibandronic acid effect in postmenopausal osteoporosis treatment can significantly bring us closer to the practical use of this results in prognostic genetics and personalized medicine. The aim was the study of associations between 283 A>G (BsmI, rs1544410) polymorphisms of vitamin D receptor gene (VDR) and ibandronic acid efficacy in postmenopausal osteoporosis treatment.

117 women with postmenopausal osteoporosis were examined through treatment dynamics. A 12-month therapy course included the use of ibandronic acid according to standard regimen. Evaluation of treatment effectiveness was carried out by changes (%) in bone mineral density (BMD) separately for each area by dual- energy X-ray absorptiometry. Real-time PCR was used to determine VDR gene rs1544410 polymorphism.

It was found that for 12 months ibandronate use caused significant (p<0.001) BMD increase. BMD increase ranged from 2.71±0.53% in left femoral neck zone to 4.63±0.53% in the L1-L4 lumbar vertebrae. The treatment outcome did not depend (p>0.05) on age, height, weight, body mass index, and postmenopause duration. GG genotype of rs1544410 polymorphism was associated with lower BMD growth rate in L1-L4 lumbar vertebrae (p=0.036).

Screening of women with postmenopausal osteoporosis for polymorphic variants of VDR gene (rs1544410) before antiresorptive therapy with ibandronic acid may be appropriate to predict the effect and individualize treatment and prophylactic measures. The obtained results can contribute to more complete understanding of osteoporosis pharmacogenetics
Nanomateriales para el transporte y liberación controlada de ciprofloxacino en aplicaciones biomédicas
Authors: Garcia Reyes Cinthia Berenice , Castillo Ramos Ventura , Mangas Garcia Guillermo , Navarrete Casas Ricardo , Sanchez Polo Manuel
Published: October 2022

urante los últimos 50 años se ha desarrollado una gran cantidad de sistemas y tecnologías de liberación controlada de medicamentos para el tratamiento de un amplio espectro de enfermedades. El objetivo es, de alguna manera, potenciar la eficacia de los fármacos administrados, especialmente de aquellos poco solubles en agua, y lograr una administración localizada evitando sobredosis que puedan provocar un desarrollo de la resistencia a dichos tratamientos. Los materiales portadores de nueva generación deben ser capaces de sobrepasar las barreras fisicoquímicas y biológicas del huésped para que sean efectivos. En este marco, la presente revisión bibliográfica tiene como objetivo introducir los nanomateriales más atractivos que se han estado desarrollado en los últimos años como portadores del antibiótico ciprofloxacino, altamente utilizado para el tratamiento de un amplio rango de infecciones y que presenta una baja solubilidad en medios acuosos, dificultando por tanto su permeabilidad celular. Los Metal Organic Frameworks (MOFSs), nanomateriales de sílice con diversas morfologías, hidrogeles y otros nanomateriales de interés han sido recogidos en el presente trabajo como portadores para la liberación controlada de ciprofloxacino, teniendo aplicaciones biomédicas potenciales tan diversas como en el tratamiento de infecciones óseas y dentales, como apósitos para la cura de heridas o incluso en tratamientos para el sistema tracto-intestinal y urinario.
Revisión sistemática de la aplicación de gestión del conocimiento y Six Sigma en instituciones de educación superior
Authors: Torres Espriu Francisco Antonio , Hernández López Ma Sandra
Published: October 2022

El presente trabajo tiene por objetivo analizar los hallazgos más relevantes referentes al tema sobre el desarrollo e implementación de modelos de gestión del conocimiento y Six Sigma en Instituciones de Educación Superior, así como su impacto en la mejora de los procesos de éstas. Para ello se llevó a cabo una revisión sistemática la cual constó de cuatro fases: 1) planteamiento de la pregunta de investigación; 2) criterios de inclusión y exclusión de la información; 3) obtención de datos y procedimiento de análisis; 4) conclusiones. Los resultados indican que, aunque hay evidencia de la aplicación exitosa de la gestión del conocimiento y la metodología Six Sigma en Instituciones de Educación Superior, no se han realizado estudios sobre la combinación de ambas en ningún tipo de organización. Se propone realizar un análisis más profundo sobre los elementos que integran ambas metodologías para lograr articular un modelo que permita alcanzar las metas que con éstas pueden alcanzarse.
Tratados Comerciales: Implicaciones para la Internacionalización del Diseñador de Moda
Authors: Aranda Contreras Elda Aurora , Rebolledo Iglesias Gilberto , Luna Gómez Alba
Published: October 2022

El presente estudio es una investigación exploratoria sobre los tratados comerciales que México tiene con países que pudieran ser de interés para que el diseñador de moda busque incursionar para expandir su presencia comercial con sus productos. Se muestra un marco teórico que expone la cantidad de tratados con los que el país cuenta actualmente y se exploran los aspectos que deben observar los diseñadores de moda en cuanto a facilidades y restricciones, considerando tratados específicos como el TMEC (Tratado de México, Estados Unidos y Canadá), el TLCUEM (Tratado de Libre Comercio de la Unión Europea y México) y el Acuerdo de Continuidad Comercial entre México y Reino Unido. Con relación a los resultados se identifican por cada tratado las principales disposiciones en temas como reglas de origen o tratamiento arancelario preferencial y finalmente, se muestran las principales semejanzas y diferencias que existen y se reflexiona sobre la accesibilidad y claridad de la información para nuestros sujetos de interés.
El compromiso organizacional un factor clave para la innovación en las Organizaciones
Authors: Placeres  Salinas Sandra Imelda , Araiza Vázquez María de Jesús , Torres Mansur Sandra Maribel
Published: October 2022

El propósito de este trabajo de investigación es presentar una revisión de la literatura que proporcione un fundamento a la base teórica, definiciones, dimensiones e investigaciones aplicadas entre el compromiso organizacional y la innovación en las organizaciones. El diseño de este trabajo de investigación es no experimental, descriptivo, apoyándose en fuentes bibliográficas y documentales. Los resultados se presentan con las principales definiciones y sus dimensiones para cada variable sujeta de estudio de este trabajo, presentando un modelo gráfico de la relación dada entre ellas y que formará parte de un siguiente estudio empírico, para la comprobación de la hipótesis planteada en este trabajo: El compromiso organizativo es un elemento que incide de manera positiva en la innovación en las organizaciones.