bluuebunny/crossref_metadata_2025 huggingface dataset:
Prosthetic Rehabilitation With Immediate Denture for Periodontally Hopeless Teeth: A Case Report
Authors: . Zuelkevin , Wahyuningtyas Endang , Amalia Kusuma Heriyanti
Published: April 2022

Background: Patient with poor oral hygiene may have periodontally diseased teeth with hopeless prognosis. The treatment is usually teeth extraction, which may be unpleasant to the patient because it can affect their appearance, speech and stomatognathic systems. It can be prevented by prosthetic rehabilitations with immediate denture. Immediate denture is a prosthodontic appliance to replace teeth and its subsequent structures which is inserted after tooth extractions.
Objectives: To observe immediate denture as a prosthetic rehabilitation treatment to replace periodontally hopeless teeth.
Case Report: We report a case of a 48-year-old woman with poor oral hygiene and elongated and mobile teeth which affected her chewing, speaking and appearance. The patient denied edentulous period. Patient management included subjective and objective examinations, preprosthetic treatment, impressions taking, diagnostic cast and working cast fabrications. Since try-in was impossible, midline position, tooth size and shade were taken in the early visit. Maxillomandibular relationship was determined and transferred to articulators. Cast modification with spatial modeling method, tooth set-up, wax modelling and insertion was done. Immediate denture was inserted right after the teeth extraction. Post-insertion control was done after one day, one week and one month.
Results: The results were esthetically satisfactory with acceptable occlusion, speech, retention and stabilization.
Conclusion: Immediate denture can be considered as a predictable treatment to replace hopeless teeth, which will restore esthetics, occlusions and speech with satisfactory retention and stabilization.
Keywords: immediate denture, periodontally hopeless teeth, prosthetic rehabilitation
Topical Application of Platelet-Rich Fibrin Liquid as a Novel and Minimally Invasive Treatment for Post-Gingival Depigmentation: A Case Report
Authors: Sari Rezmelia , Agung Wibawa Abizar
Published: April 2022

Background: Gingival depigmentation is a common perio–esthetic surgery which results in extensive open wounds, discomfort and increased risk of infection. Cellulosebased periodontal dressing (CBP) can protect the wound, has less toxicity than Coe-Pak but no curative effect. Platelet-rich fibrin (PRF) membrane has been shown to accelerate wound healing after gingival depigmentation, but it requires suturing which causes patient discomfort. A simple and minimally invasive technique is needed to optimize the use of PRF which is convenient for both the operator and the patient.
Objective: To investigate post-gingival depigmentation outcome – wound healing, pain and post-surgical complaint – after PRF liquid application compared to CBP.
Case Report: A 24-year-old male presented with a complaint of blackish gum that affected his self-confidence. The patient had a history of smoking for the last five years. Gingival depigmentation was carried out using a scalpel followed by the application of CBP (right) and PRF liquid (left). Evaluation was done using the Visual Analogue Scale (VAS) and the Healing Index (HI) on days 3, 7 and 14 after depigmentation, followed by evaluation using the Adobe Photoshop CS2.
Results: On day 3, the PRF HI was higher than that of the CBP. No postoperative complaint in the PRF group and the VAS score was similar.
Conclusion: The results suggest that PRF liquid provides better post-gingival depigmentation healing than CBP on the third day post treatment. Furthermore, utilization of PRF liquid is expected to be an alternative for minimally invasive open wounds management especially post-gingival depigmentation.
Keywords: gingival pigmentation, platelet-rich fibrin liquid, cellulose-based periodontal dressing, wound healing, case report
Treatment of Altered Passive Eruption Type 1B: A Case Report
Authors: Pramestri Lastianny Sri , Perwitasari Amalia
Published: April 2022

Background: The appearance of the gingival tissue around the teeth plays an important role for the aesthetics. Abnormalities in symmetry and contour of gingival tissue affects the harmonization of the teeth’s appearance. Excessive gingival display (EGD) or gummy smile, short clinical crown of tooth are frequent complaints of patients. There are various factors that can cause a gummy smile and a short clinical crown, one of which is altered eruption. The procedure that can provide a solution to this aesthetic, periodontal and restorative problem is crown lengthening. Crown lengthening is a surgical procedure that aims to remove periodontal tissue to increase the clinical length of the dental crown, the crown-lengthening procedure can be achieved with or without bone reduction.
Objective: To describe the management of altered passive eruption type 1B by crown lengthening with osteotomy procedure.
Case Report: A 20-year-old female patient presented to the periodontics clinic of RSGM Soedomo UGM, with a complaint of excessive gum appearance with her right upper front tooth looking short when she smiled. The patient was diagnosed with altered passive eruption. The treatment was crown-lengthening surgery with osteotomy.
Conclusion: Crown lengthening is an effective treatment to retrieve functional and aesthetic disturbances associated with altered passive eruption.
Keywords: gummy smile, altered passive eruption, crown lengthening surgery
Intracoronal Splinting as an Initial Treatment for Patients with Tooth Mobility: A Case Report
Authors: Herawati Dahlia , Aulia Azhar Syafrudin
Published: April 2022

Background: Tooth mobility is a problem that often results in tooth loss due to disease or injury to the gingiva or bone that supports the teeth. Tooth mobility is one of the clinical features of periodontal disease caused by alveolar bone destruction, occlusion trauma and the expansion of inflammation from the gingiva to the deeper supporting tissues. One of the treatments for stabilizing tooth mobility is splinting. Various types of splints can be used as an initial therapy for the treatment of periodontal disease so that the teeth become more stable for further treatments.
Objective: To describe the correction of tooth mobility with splint.
Case Report: A 64-year-old patient presented to the periodontics clinic of Dental and Oral Hospitals Gadjah Mada University (RSGM UGM) with complaints of inferior front teeth mobility. The patient had a history of controlled diabetes mellitus. The management of this case was done by an initial treatment of scaling root planning (SRP) and intracoronal splint.
Results: The four-week control showed more stable teeth and further treatment was possible.
Conclusion: The periodontal splint can be used as an initial treatment for patients with periodontal disease because the mobile tooth is supported by another tooth, thereby increasing comfort during mastication.
Keywords: tooth mobility, diabetes mellitus, splint, intracoronal splint
Management of Fibrous Epulis of Anterior Maxillary Teeth: A Case Report of a 1.5-Year-Old Lesion
Authors: Murdiastuti Kwartarini , Salma Nurbaiti Mentari
Published: April 2022

Background: Epulis is a gingival hyperplasia (tumor-like) that originates from periodontal connective tissue. It can be caused by many factors such as a chronic local irritation. Epulis that grows on the anterior maxilla area can be inconvenient because it disrupts the aesthetics and also the function of the teeth. Therefore, it has to be completely removed by surgery.
Objective: To correct the condition of epulis by excision and gingival contouring for aesthetic need.
Case Report: A 30-year-old female patient presented with a complaint of a mass on the gum of the anterior teeth on her upper jaw that made her unconfident to smile. The mass had been there for 1.5 years.
Conclusion: The condition of epulis can be corrected by excision procedure and by removing the cause of the epulis (sub-gingival calculus). The aesthetic result can be obtained by gingival contouring after the excision.
Keywords: epulis, fibrous epulis, gingival hyperplasia, excision, gingival contouring, gingival biopsy
Surgical Incision Flap for the Management of a Patient With Gingival Enlargement Exacerbated by Malpositioned Teeth: A Case Report
Authors: Syaify Ahmad , Amira Tasya
Published: April 2022

Background: Gingival enlargement is a disorder caused by plaque and calculus, exacerbated by malpositioned teeth and trauma from occlusion.
Objective: To discuss the management of gingival enlargement that exacerbates malpositioned teeth with surgical incision flap.
Case Report: A 26-year-old male patient presented with a complaint of enlarged gums in the lower front area with malpositioned teeth, food impaction, bleeding when brushing and discomfort because of the calculus for last six months. The patient had never been to a dentist before. The treatment given was scaling and root planning in the initial phase and gingival enlargement correction with surgical incision flap in the corrective phase.
Conclusion: The gingival enlargement cannot be done with surgical incision flap alone, the local secondary etiology has to be removed, therefore, a comprehensive treatment is required.
Keywords: gingival enlargement, incision flap, malpositioned teeth
Nueva variante del gen STAG3 causante de insuficiencia ovárica prematura
Authors: Gómez-Rojas Susana , Aristizábal-Duque Jorge Enrique , Muñoz-Fernández Luisa Fernanda , Sarmiento-Ramón María Paula , Pereira-Gómez María del Pilar
Published: April 2022

Objetivos: describir un caso de falla ovárica secundaria a una variante patogénica homocigota en el gen STAG3 no reportada previamente.
Materiales y métodos: paciente de 16 años con amenorrea primaria y ausencia de características sexuales secundarias, en quien se documentó hipotiroidismo autoinmune, pobre desarrollo genital y cintilla gonadal, por lo cual se realizó secuenciación de exoma clínico. Se identificó una variante homocigota patogénica previamente no reportada en el gen STAG3, el cual ha sido relacionado con insuficiencia ovárica prematura (IOP).
Conclusiones: en este caso, la realización de exoma clínico fue determinante para identificar una alteración del gen STAG, probablemente asociada a la IOP y el pronóstico a largo plazo de la paciente. Se establece una nueva variante patogénica c.2773delT; p.Ser925Profs*6  del gen STAG3 asociada a la IOP.
Palabras claves: hipogonadismo, insuficiencia ovárica primaria, disgenesia gonadal, autoinmunidad, secuenciación del exoma completo.
Consideraciones generales sobre la relación entre los lenguajes científicos y la lengua cotidiana
Authors: Renwick Ricardo
Published: April 2022

No contiene resumen
Transitividad, aglutinación y subordinación en lengua quechua
Authors: Calvo Pérez Julio
Published: April 2022

No contiene resumen
White Grub ‘Kurmula’ Holotrichia spp. an Agriculture Important Pest in India: A Review
Authors: Gautam M.P. , Doharey R.K. , Singh Shesh Narain
Published: April 2022

White grubs are the distractive, public Importance and a genuine requirement to Kharif crops become under rainfed conditions. Both the grubs and grown-ups are polyphagous and univoltine. No single control measure is powerful for their administration consequently is the lone alternative for their compelling administration in the sloping zone. Therefore, the stock of the insects joins 24 species having a place with 13 genera under 5 subfamilies. White grubs are larvae of melolonthinae (Scarabaeidae : Coleoptera) but the term includes larvae of Rutelinae, Dynastinae, Cetoniinae and other families of Scarabaeidea superfamily. The use of the compound bug spray on the banks of the stream makes the water contamination the following towns and makes the odds of obstruction improvement in bother. White grub damage typically appears as stunted, wilted, discolored, or dead seedlings and/or as gaps in rows where plants fail to emerge. White grubs prune roots and can feed on the mesocotyl causing plant death.
Effect of Land Use on Plant Nutrient Availability and Soil Carbon Stock of Mokonisa Machi Watershade, Dugda Dawa Woreda, West Guji Zone, Southern Ethiopia
Authors: Urgessa Haile Tamiru , Ferede Taadele Geneti
Published: April 2022

Background: Various land use practices have a different influence on soil degradation on both physical and chemical property of soil as well as on soil carbon sequestration capacity. A small number of studies have studied the effects of land use on plant nutrient availability and soil carbon sequestration in Ethiopia. Therefore, current study was to explore the effects of land use on vegetation nutrient accessibility and soil carbon restoration. Methods: Further definitely the study pointed out the difference between various land use category on soil texture, soil pH, available phosphorus and exchangeable potassium and the implication the farming practices on soil carbon sequestration. Soil sample were collected from the upper 0-40 cm depth of forest land, cultivated land and grazing land. The soil texture was primarily clay and heavy clay textural class. Result: Along soil depth, bulk density (BD) increasing ranges from (1.12 to 1.27 g/cm in all sampling sites. Slight increase in pH was recorded with increase in soil depth in all land use system. The average total soil organic carbon stock forest, grazing and farm land was ranged between 95.2, 88.45 and 65.5 t/ha, respectively for surface soil and 93.3, 73.75, 62.5 respectively for sub surface soil. Soil organic carbon concentration and bulk density improvement are the most important management interventions to increase soil organic carbon storage capacity.
​​Importance of Right Pulmonary Artery Distensibility Index in the Diagnosis and Management of Pulmonary Arterial Hypertension Secondary to Canine Dilated Cardiomyopathy
Authors: Reddy K. Basava , Kamran C. Ansar , Ramesh P.T. , Upendra H.A. , Rao Suguna , Mahesh V.
Published: April 2022

Background: The measurement of tricuspid regurgitant velocity is the commonly used non-invasive method for the diagnosis of pulmonary hypertension in dogs. It is anticipated that M-mode echocardiographic measurement of right pulmonary artery distensibility (RPAD) index is simple and provides accurate means for the diagnosis of pulmonary arterial hypertension when tricuspid regurgitant velocity is absent. Hence this study was undertaken to evaluate the importance of RPAD index in the diagnosis and management of pulmonary arterial hypertension secondary to dilated cardiomyopathy. Methods: In the present study, a total of 165 dogs were subjected to echocardiography for diagnosis of pulmonary hypertension secondary to dilated cardiomyopathy. The maximum and minimum internal diameter of the right pulmonary artery during systole and diastole were quantified respectively to determine the right pulmonary artery distensibility (RPAD) index in right parasternal short axis M-mode echocardiogram. The M-mode morphology of right pulmonary artery (anterior dicrotic notch) also recorded. Result: Out of 165 dogs ten dogs had pulmonary arterial hypertension with dilated cardiomyopathy. Dogs with pulmonary hypertension showed a significant decrease in the mean right pulmonary artery distensibility index values and Acceleration time/Ejection time (AT/ET) ratio, while the mean tricuspid regurgitant systolic pressure gradient (TRPG) were significantly elevated when compared to the respective control group. The significant difference was observed in the mean values of tricuspid regurgitant systolic pressure gradient and RPAD index before and after the treatment.
Agronomic Biofortification of Zinc and Iron on Yield Potential and Zinc Fortification in Chickpea (Cicer arietinum L.) Varieties under Arid Western Plains Zone of Rajasthan
Authors: Kharra Rekha , Shukla U.N. , Dhayal B.C. , Choudhary R. , Raiger P.R. , Bijarnia K.K.
Published: April 2022

Background: According to the World Health Organization on worldwide prevalence of micronutrient deficiencies, zinc deficiency ranked 11th amongst twenty most important factors in the world, whereas zinc and iron deficiency ranks 5th and 6th respectively, amongst ten most important factors in developing countries. Among micronutrients, zinc (Zn) and iron (Fe) deficiency in human nutrition are wide spread in Asian developing countries including India. Therefore, agronomic biofortification is easiest and immediate effective method for enriching seed with zinc and iron, which could relieve malnutrition issues in developing countries, particularly in India. Methods: A field trial was carried out to study the agronomic biofortification of zinc and iron in chickpea (Cicer arietinum L.) varieties under Arid Western Plains Zone of Rajasthan. Growing of two varieties namely GNG-1581 and RSG-974 and seven fortification treatments included various doses of zinc and iron were assigned under FRBD and trial was carried out at Instructional Farm, College of Agriculture, Jodhpur (Rajasthan) during rabi season of 2019-20. Result: The results revealed that significantly higher yield attributes and yield viz. pods plant-1 and 100-grain weight were produced under the RSG-974, while higher number of seeds pod-1 as well as seed, stover and biomass yield along with higher zinc contents and their uptakes were noticed in chickpea variety GNG-1581 under application of ZnSO4 @ 25 kg ha-1 (SA) + 0.5% FeSO4 (FA).
Bilgisayar görme sendromunda gözyaşı fonksiyonu ve kornea biyomekanik özelliklerinin değerlendirilmesi
Authors: ORMAN Gozde , SUNGUR Gulten , CANDAN Özlem
Published: April 2022

Amaç: Bilgisayar görme sendromu (BGS) uzun süreli bilgisayar kullanımından kaynaklanan görsel, oküler ve kas-iskelet sistemi semptomlarını tanımlamak için kullanılan bir terimdir. Bilgisayar kullanımı göz kuruluğunu artırır ve gözyaşı fonksiyon testlerinde bozulma yapar. Bu çalışmanın amacı bilgi işlem personellerinde göz kuruluğu testleri ve oküler cevap analizörü (OCA) parametrelerinin bilgisayar kullanımı sonrası etkilenip etkilenmediğini değerlendirmektir.

Gereç ve Yöntemler: Bu çalışma Sağlık Bilimleri Üniversitesi Ankara Eğitim ve Araştırma Hastanesi Göz Kliniği’nde tarafından yapılmıştır. On sekiz gönüllü bilgi işlem personelinin otuz altı gözü çalışmaya dahil edildi. Bilgisayar kullanmadan mesai öncesi ve mesai sonrası gönüllülere otorefraktometre, Snellen eşeli ile en iyi düzeltilmiş görme keskinliği (EDGK) muayenesi, aplanasyon ile göz içi basınç ölçümü (GİB) (Goldmann aplansyon tonometresi), Schirmer II testi, göz yaşı kırılma zamanı (GKZ), biyomikroskopik muayene, santral kornea kalınlığı (SKK) ve OCA testi uygulandı.

Bulgular: Gönüllülerin 10’u kadın 8’i erkek, yaş ortalamaları 38,6±5,1idi. Mesai öncesi Schirmer II testinin ortalaması 13,2±1,8 mm, mesai sonrası 4,9±0,5 mm idi (p < 0,001) ve GKZ mesai öncesi ortalaması 11,2±0,7 sn, mesai sonrası 5,7±0,6 sn idi (p < 0,001). Mesai öncesi ve sonrası bakılan OCA parametre değerleri arasında istatiksel olarak anlamlı fark yoktu; sırasıylakorneal histerezis (p= 0,58), korneal direnç faktörü (p=0,46), kornea düzeltmeli GİB (p=0,11), SKK (p=0,44) ve Goldman uyumlu GİB (p=0,19).

Sonuç: Giderek artan teknolojik gelişmeler ile hayatımıza giren bilgisayarlar göz sağlığımızı etkilemektedir. BGS her ne kadar kuru göze sebep olsa da gün içinde bilgisayar kullanımı kornea biyomekaniğini etkilememektedir.
SİNONAZAL İNVERTED PAPİLLOMLU VAKALARDA KROMOZOMAL MİKROARRAY ANALİZİ
Authors: ÇİTLİ Şenol , ERDİM İbrahim , SAPMAZ Emrah , SOMUK Battal Tahsin
Published: April 2022

Amaç: Mikroarray yöntemiyle sinonazal inverted papillomlu (SNIP) hastalarda etiyolojiden sorumlu olabilecek olası genetik varyasyonları saptamak

Gereç ve Yöntem: Üçüncü basamak bir hastanenin Kulak-Burun-Boğaz Anabilim dalı tarafından Ocak 2014 - Ocak 2019 yılları arasında SNIP nedeniyle opere edilmiş 16 kişi hastane kayıtlarından tespit edildi. Ulaşılabilinen ve herhangi bir konjenital sistemik hastalığı olmayıp çalışmaya katılmayı kabul eden 7 kişi çalışmaya alındı. Çalışmaya alınan vakalara Tıbbi Genetik Anabilim dalı tarafından kromozomal mikroarray analizi (KMA) uygulandı.

Bulgular: KMA yaşları 29 ile 67 arasında değişen altı erkek ve bir bayan hastaya uygulandı. Vakalardan birinde (Vaka 7) hiç bir varyant saptanamazken diğer altı vakada benign varyantlar tespit edildi. Altı vakada ortak olarak 14q32.33 lokalizasyonundaki duplikasyon varyantı görüldü. Varyantların üçü (6p25.3, 7q11.21, 14q32.33) herhangi bir gen içermezken 22. kromozom üzerinde saptanan diğer iki varyasyonun gen içeriği mevcuttu. Bunlardan vaka1 ve vaka4 de saptanan 22q11.21 lokalizasyonundaki ortalama büyüklüğü 12 kilobaz (kb) olarak saptanan duplikasyon şeklindeki varyasyon Tbx1 genini içerirken sadece vaka 5’te saptanan 22q11.22 lokalizasyonundaki yaklaşık 150 kb büyüklüğe sahip varyasyon mir650 genini içermektedir. Çalışmada ayrıca delesyon şeklinde saptanan tek Copy Number Varyasyon (CNV) 6p25.3 lokalizasyonundaki gen içeriği olmayan yaklaşık 30 kb büyüklüğüdeki varyasyondu. Bunun dışında saptanan CNV’lerin hepsi duplikasyon şeklindeydi.

Sonuç: Çalışmamızda SNIP’lu hastalarda benign varyasyonlar saptamakla beraber herhangi bir patojenik veya olası patojenik varyasyon saptanmamıştır.
Optik Nörit ve Abdusens Sinir Paralizisi İle Seyreden Nörobruselloz: Olgu sunumu
Authors: CEYLAN Mehmet Reşat , ESMER Oktay , YAKAN Ümit , MENTEŞ Osman , KARAHOCAGİL Mustafa Kasım
Published: April 2022

Bruselloz, Brucella cinsinin neden olduğu multisistem tutulumu olan enfeksiyöz bir hastalıktır. Menenjit, meningoensefalit, miyelit, radikülonörit, beyin apsesi, epidural apse ve meningovasküler sendromlar gibi nörolojik komplikasyonlara nadiren rastlanır. Sol abdusens sinir felci ve optik nörit ile başvuran bir bruselloz olgusunu sunuyoruz. Beyin omurilik sıvısı bulguları yüksek protein sayısı, düşük şeker düzeyi ve pleosistosis ile Brucella menenjitini gösterdi. Ayrıca beyin omurilik sıvısında Brucella aglütinasyon testi (Wright testi) 1/160 olarak bulundu. Brucella için serum aglütinasyon testi de 1/640'da pozitifti. Bu olguya abdusens ve optik sinirleri tutan nörobruselloz tanısı konuldu. Hasta seftriakson (intravenöz), siprofloksasin (oral) ve doksisiklin (oral) ile tedavi edildi. Tedaviden dört hafta sonra papil ödemi geriledi, sol gözdeki içe kayma, çift görme şikayetleri azaldı ve 12 hafta sonunda hastanın tüm bulguları düzeldi. 1 yıllık takipte nüks gözlenmedi. Brusellozun endemik olduğu bölgelerde çift görme şikayeti ile başvuran ve muayenesinde altıncı sinir felci olan hastalarda ayırıcı tanılar arasında nörobrusellozun düşünülmesi gerektiği kanaatindeyiz.
ÜST KAPAK BLEFAROPLASTİ CERRAHİSİNDE ÇIKARILAN DOKU MİKTARININ CERRAHİ SONUÇLAR VE HASTA MEMNUNİYETİ ÜZERİNE ETKİSİNİN DEĞERLENDİRİLMESİ
Authors: ÇORAK EROĞLU Fatma , KAZANCI Burcu
Published: April 2022

AMAÇ: Üst kapak blefaroplasti uygulanan olgularda ekzise edilen doku miktarının cerrahi sonuçlar, iyileşme süresi, komplikasyon oranları, skar gelişimi ve hasta memnuniyeti üzerine olan etkisini araştırmak.

GEREÇ ve YÖNTEM: Bu prospektif çalışmaya tamamı üst kapak blefaroplasti uygulanmış 94 hastanın 188 gözü dahil edildi. İntraoperatif olarak eksize edilen doku miktarı kaydedilerek cilt, cilt/kas, cilt yağ ve cilt/kas/yağ dokusu olarak sınıflandırıldı. Hastalar cerrahi sonuçlar, komplikasyon gelişimi, skar gelişimi ve iyileşme süresi açısından değerlendirildi. Postoperatif 3. ayda, hastalara cerrahi memnuniyet anketi ile birlikte, hastaların yaşam kalitesindeki değişimi, cerrahi yarar algısını ve bu değişimin özelliklerini belirlemek için Glasgow Yarar Envanter (GYE) anketi uygulandı. Eksize edilen doku miktarı ile iyileşme süresi, komplikasyon gelişimi, skar gelişimi ,GYE skoru ve cerrahiden memnuniyet düzeyi arasındaki ilişki araştırıldı.

BULGULAR: Yaş ortalaması 55,2 ±7,6 yıl olup, hastaların % 78,7’si kadındı. Hastaların 19’una yalnızca cilt eksizyonu, 38’ine cilt ve kas eksizyonu, 7’sine cilt ve yağ eksizyonu, ve 30’una ise cilt, kas ve yağ eksizyonu uygulanmıştı. Hastaların %81.9’u geçirdikleri cerrahiden çok memnun olduğunu, %11,7’si memnun olduğunu, %5,3’ü orta düzeyde memnun olduğunu ve %1,1’i memnun olmadığını ifade etti. GYE anket sonucuna göre, hem total GYE skorunda hem de alt skorlarda artış saptandı. Eksize edilen doku miktarı ile cerrahi sonuçlar, iyileşme süresi, skar oluşumu, komplikasyon oranları, hasta memnuniyeti ve GYE skoru arasında anlamlı bir fark yoktu (p>0,05).

SONUÇ: Üst kapak blefaroplasti cerrahisinden sonra, eksize edilen doku miktarından bağımsız olarak, hastaların büyük kısmında fonksiyonel iyileşme ile birlikte hasta memnuniyetinde ve cerrahi yarar algısında artış meydana gelmiştir.
EAU BORİQUE SOLÜSYON VE RADYODERMATİT ÜZERİNE ETKİSİ
Authors: SAYIN Meral
Published: April 2022

AMAÇ: Meme kanseri tedavisinde uygulanan, adjuvan radyoterapiye bağlı gelişen cilt toksisiteleri ve radyodermit tedavisinde kullanılan, 2 farklı tedavinin sonuçları karşılaştırıldı. Radyodermatit gibi radyoterapinin en sık görülen yan etkisinde güvenilir ve ucuz bir yöntem olan, Eau Borique solüsyonunun iyileşme üzerindeki etkisi araştırıldı.

GEREÇ VE YÖNTEM: Çalışma Ankara Eğitim ve Araştırma Hastanesinde , meme kanseri tanısı almış, adjuvan radyoterapi almış ve cilt toksisitesi gelişen hastalar üzerinde yapıldı. Hastalar 2 grupta incelendi. Eau borique solüsyonu uygulanan hastalara karşı diğer grupta prednasinolon içerikli krem kullanan hastalar incelendi. Retrospektif gözlemsel taramaların sonuçları için SPSS 25 ve Microsoft Office Excel 2007 kullanıldı.

BULGULAR: 80 hasta dosyası incelendi ve izlemleri yapıldı. Hastaların izlemlerinde Eau Borique solüsyon kullanan grupta ortalama iyileşme süresinin 10.2 gün (min:6, maks:20) olduğu, prednasinolon kullanan grupta ise 14 güne (min:6, maks:29) kadar uzadığı görüldü. Aralarında istatistiksel olarak anlamlı fark vardı(p:0.002). Diyabetli hastaların ise radyodermit iyileşme sürelerinde de Eau Borique grubu daha iyi olduğu görülse de, özellikle yaş deskuamasyon olan diyabetli hastaların Eau Borique grubunda daha erken iyileşme ve semptomlarda azalma görüldü.(16.6 güne karşı 22 gün.p: 0.02)

SONUÇ: Eau Borique solüsyonun özellikle açık, deskuame yarası olan ve diyabetli hastalarda iyileştirici etkisi fark ediliyor. Böylece cilt toksisiteleri erken dönemde iyileşmekte, tedaviye devam ve hasta konforu açısından önem kazanmaktadır. Grade 2 ve üstü cilt toksisite görülen hastalarda Eau borique solüsyonu reçete edilmesi ciddi fayda sağlar.
Influencia del autoconcepto y autoeficacia académica sobre la procrastinación académica en universitarios peruanos
Authors: Pichen-Fernandez Juan Alberto , Turpo Chaparro Josue
Published: April 2022

El objetivo de esta investigación fue determinar si el autoconcepto académico y autoeficacia académica predicen la procrastinación académica en estudiantes universitarios de la región de La Libertad. Se analizaron los datos de 386 estudiantes universitarios de ambos a través de una estrategia asociativa con un diseño predictivo transversal. Los cuestionarios usados fueron la Escala de autoconcepto AF5 (ECT), la escala EAPESA para autoeficacia y la escala de Procrastinación EPA. Se encontró que existe relación estadísticamente significativa y práctica entre las variables de estudio (p < .01) y que el coeficiente de determinación R2 = ,273 indica que el autoconcepto académico y autoeficacia académica explican el 27,3 % de la varianza total de la variable criterio procrastinación académica. Se concluye que los coeficientes β (-,382, -,201) indican que el autoconcepto académico y la autoeficacia académica (variables predictoras) predicen significativamente la procrastinación académica (variable criterio).
Engineered induced-pluripotent stem cell derived monocyte extracellular vesicles alter inflammation in HIV humanized mice
Authors: Sun Bing , Kitchen Scott , Tang Norina , Garza Andreas , Jacob Sheela , Pulliam Lynn
Published: April 2022

Aim: A peripheral inflammatory response can drive neuroinflammation in a number of infections including human immunodeficiency virus (HIV). Monocyte/macrophage (M/Mφ) activation is a hallmark of acute HIV infection and a source of chronic inflammation in a subset of HIV-infected individuals. We sought to decrease peripheral inflammation and M/Mφ transmigration after HIV infection by engineering extracellular vesicles (EV) to antagonize a microRNA (miR) associated with inflammation. We hypothesized that induced pluripotent stem cell (iPSC)-derived monocyte EVs (mEVs), engineered to contain an antagomir to miR-155 (αmiR mEV) would target monocyte inflammation and influence neuroinflammation in an HIV-infected humanized mice. Methods: mEVs were characterized by tetraspanins, nanoparticle tracking analysis, electron microscopy, and their preferential entry into circulating monocytes as well as testing for endogenous selected miRNAs. HIV-infected humanized mice were treated with control or antagomir155 mEVs. Plasma viral load was measured plus activation markers on lymphocytes and monocytes and the number of macrophages in the brain was quantified. Results: mEVs preferentially entered peripheral monocytes. HIV infection increased C-C chemokine receptor type 5 (CCR5) and major histocompatibility complex, class II, DR (HLA-DR) expression on T cells and monocytes. Treatments with mEVs did not decrease plasma HIV viral load; however, mEVs alone resulted in a decrease in %CCR5+ and %HLA-DR+ on T cells and an increase in %CCR5+ monocytes. αmiR mEVs decreased %CCR5 on M/Mφ. The mEV-treated HIV-infected mice did not show an increase in macrophage transmigration to the brain. Conclusion: mEVs alone caused an unexpected decrease in lymphocyte activation and increase in monocyte %CCR5; however, this did not translate to an increase in macrophage transmigration to the brain.
ANTIBACTERIAL EFFECTIVENESS TEST OF RAMANIA LEAVES (Bouea macrophylla Griffith) FLAVONOIDS EXTRACT ON Aggregatibacter actinomycetemcomitans
Authors: Khalishah Noor , Widya Oktiani Beta , Adhani Rosihan
Published: April 2022

Background: Aggressive periodontitis is a disease that is mostly suffered by young patients with minimal local factors. The prevalence of this disease is approximately 8% in Indonesia, where Aggregatibacter actinomycetemcomitans bacteria are presented as dominant bacteria in this disease. Aggregatibacter actinomycetemcomitans is a gram-negative bacterium that is sensitive to flavonoids. Ramania leaves are natural substances which contain flavonoids. Flavonoids in ramania leaves can be applied as an antibacterial substance. Objectives: The objectives of this research are to determine and analyze the minimum inhibitory concentration and the minimum bactericidal concentration of flavonoids extract from ramania leaves at the concentration of 0.1%, 0.3%, and 0.5%, and analyze the antibacterial effectiveness on Aggregatibacter actinomycetemcomitans. Methods: True experimental design with pre and post-test with control group design was applied in this study. Antibacterial test using broth and agar dilution method was performed in a total of 5 treatment groups with 6 repetitions. Results:  All exract at 0.1%, 0.3% and 0.5% concentration demonstrated the ability to inhibit bacterial growth, and the minimum bactericidal concentration was found at 0.5% concentration. Result test for One way ANNOVA on minimum inhibitory concentration and Kruskal wallis test on minimum bactericidal concentration exhibited significant value of less than 0.05 presenting significant differences in some groups. Conclusion:  Minimum inhibitory concentration of ramania leaves flavonoid extract is effective on Aggregatibacter actinomycetemcomitans at the concentration of 0.1% and minimum bactericidal concentration of ramania leaves flavonoid extract is more effective at the concentration of 0.5%
THE EFFECT OF BINJAI (Mangifera caesia) LEAVES EXTRACT GEL TO COLLAGEN FIBER DENSITY ON WOUND
Authors: Damayanti Novia , Taufiqurrahman Irham , Putri Utami Juliyatin
Published: April 2022

Background: Binjai (Mangifera caesia) leaves extract contains flavonoid, saponin, phenolic, tannin, alkaloid and triterpenoid. The said contents are known to help the process of wound healing. Gel formations contains a lot of water, resulting in substance penetration into the tissue will be better if used as wound healing adjuvant therapy. Purpose: To analyze the effect of binjai leaves extract gel (Mangifera caesia) that topically given to collagen fiber density on the wistar rat incision wound. Methods: This research was a true experimental with post test only with control group design that consists of 4 groups. Group I has been given the placebo gel as control, group II, III and IV have been given the binjai leaves extract gel with 5%, 10% and 15% concentration that observed on the 7th day and 14th day. The collagen fiber density assessed by measuring hydroxyproline with Stegmann and Stalder method. Results: The research result shows that the 15% concentration of binjai leaves extract gel has a better effect on collagen fiber density compared to 5% and 10% concentrations. Two-way Anova data analysis revealed that the significant difference average of collagen fiber density of the whole group with the value of sig.p < 0,05. Conclusion: The 15% concentration of binjai leaves extract gel has the most optimal effect compared with the 5% and 10% concentrations to collagen fiber density on the wistar rat incision wound.
THE EFFECT OF SPRAYING MAULI BANANA (Musa acuminata) STEM EXTRACT 25% CONCENTRATION ON THE DIMENSIONAL STABILITY OF ALGINATE IMPRESSION
Authors: Prasetya Syaiful Haq , Arifin Rahmad , Hamdani Riky
Published: April 2022

Background: Alginate is an ingredient derived from brown seaweed extract which is anhydro-P-d-mannuronic acid. Alginate is often used as an impression material. A factor that must be considered when using impression materials is to prevent the infection. Prevention of infection transmission is done by administering disinfectants by spraying. However, this material has imbibition properties and expansion can occur in the model. 25% Mauli banana extract solution can be used as a disinfectant in alginate impressions and does not affect the dimensional stability of the alginate impressions. Objective: To analyze the effect of spraying mauli banana (Musa acuminata) stem extract 25% concentration on the dimensional stability of alginat impression. Methods: This research was pure experimental research using pretest-posttest and control group design. The research sample consisted of 15 samples that divided into 3 groups; aquades, 1% sodium hypochlorite, and 25% Mauli banana stem extract. The research data were analyzed using One Way Anova. Results: The average value calculation of the difference before and after spraying the aquades was 0.504  mm, the 1% sodium hypochlorite group was 0.502 mm and the 25% Mauli banana stem extract was 0.328 mm. Statistical tests showed no significant differences among all treatment groups on alginate dimensional stability or there was no effect on spraying 25% Mauli banana stem extract in the dimensional stability of alginate impression with sig. 0,401 (p > 0.05). Conclusion: There was no significant effect on spraying Mauli banana (Musa acuminata) stem extract 25% on the dimensional stability of the alginate impression.
RELATIONSHIP OF PARENTS ROLE TO CARIES INCIDENT IN ADOLESCENTS AT SUNGAI LOBAN SUBDISTRICT
Authors: Soviarini Nindica Ayu , Dharmawan Setyawardhana R. Harry , Dwinta Sari Galuh
Published: April 2022

Background: Caries can be caused by a lack of individual knowledge about dental health and attitudes to pay attention to dental hygiene. Parents have the most important role in determining the personality, habits and behavior of the child in taking care of the teeth and mouth. Every action taken by the parents will have an influence on the character of the child. Parents who provide a positive parenting pattern to their child, will form good personality, habits and behavior towards the child. But on the contrary, parents who are less attentive and do not care will form negative personalities, habits and behaviors.  Purpose: To find out relationship of parents role to caries incident in adolescents at Sungai Loban Subdistrict. Methods: This study used an observational analytic method in the form of cross-sectional research and a simple random sampling technique. The research population was grade VII students at SMP Negeri 1 Sungai Loban as many as 63 respondents. Results: The Spearman test obtained significant score results of 0.000<0.05 which means there is a correlation between the role of parents to the incidence of caries in children. The correlation value is  – 0.927 and includes a very strong correlation in the negative direction (-), it can be interpreted that the relationship is opposite or if the child's caries is high then the role of parents tends to be low. Conclusion: There is a relationship of parents role to caries incident in adolescents.
EFFECT OF KARAMUNTING LEAF EXTRACT (Melastoma malabathricum) ON THE PROLIFERATION OF BABY HAMSTER KIDNEY-21 (BHK-21) FIBROBLAST CELLS
Authors: Ramadamayati Aanisah , Ichrom Nahzi Muhammad Yanuar , Wardhana Agung Satria
Published: April 2022

Background: Pulpitis is an inflammation of dental pulp due to infection of microorganisms from dental caries. Pulpitis is clinically divided into reversible and irreversible pulpitis. Treatment of reversible pulpitis can be done by applying a pulp capping material. The use of calcium hydroxide as a pulp capping material is still not optimal, so an alternative material is needed, namely karamunting leaf (Melastoma malabathricum). The secondary metabolites in karamunting leaf extract have antibacterial activity. Antibacterial activity is needed in the regeneration of pulp tissue. Purpose: To analyze the effect of karamunting leaf extract (Melastoma malabathricum) on viability and proliferation of Baby Hamster Kidney-21 (BHK-21) fibroblast cells using the MTT Assay method. Methods: This study is a purely experimental study with post test only with control group design which were divided into 8 groups. The group was treated with karamunting leaf extract consisted of 5 groups, were 5%, 10%, 15%, 20%, and 25% concentrations also 3 control groups, were positive control (calcium hydroxide), cell control, and media control. Absorbance value was read using ELISA Reader and the percentage of cell viability was calculated. Results: All treatment groups had cell viability values higher than cell control and cause proliferation of BHK-21 fibroblast cells. The One Way Anova showed a value of sig=0,000 (p<0,05), which means that there was a minimum difference in one treatment group. Conclusion: Karamunting leaf extract and calcium hydroxide can maintain viability and cause proliferation of BHK-21 fibroblast cells. Karamunting leaf extract 25% concentration more effective in causing proliferation of BHK-21 fibroblast cells.
OUTDOOR ACTIVITIES MODIFICATION AND RECURRENT INTRAORAL HERPES IN ELDERLY PATIENT: CASE REPORT
Authors: Yusuf Adi Ahmad , Hidayat Wahyu
Published: April 2022

Background: Infections caused by the herpes simplex virus (HSV) are infections that often occur in the oral and perioral areas. One of the recurrent herpes infections in the orofacial area is recurrent intraoral herpes (RIH).  Purpose: To discuss treatment management of RIH and lifestyle modification in physically active elderly patients. Case Report: A 67 year old male patient came to Oral Medicine clinic of RSGM Unpad with complaint of recurrent ulcers in the oral cavity, this ulcers started 3 days earlier and no history of fever. Patient daily ativities including walking 8 to 9 km a day. Laboratory examinations showed an increase value of IgG HSV-1. Intraoral examination, multiple ulcers were found on the left lateral tongue, ventral tongue, upper labial mucosa, right labial mucosa and left buccal mucosa. Case Management: The patient was given acyclovir 200 mg, 5 times a day for 1 week. After one week, there was no improvement, new ulcers still appeared,we suggest that this is due to the patient still active as usual. Patient was given acyclovir 400 mg 5 times a day for 1 week, multivitamins and chlorhexidine digluconate 0,12% mouthwash, the patient was also instructed to reduce the frequency of outdoor activity and use sunscreen. On the third visit, patient was comfortable, the ulcers had healed and there were no new lesions. Conclusion: In addition to systemic medical treatment management for RIH, it is also necessary to consider lifestyle modifications in these patients by reducing the intensity of physical activity and use sunscreen.
VIABILITY OF DUAL-SPECIES BIOFILM OF STREPTOCOCCUS MUTANS AND LACTOBACILLUS ACIDOPHILUS AFTER APPLICATION OF MAULI BANANA STEM GEL
Authors: Carabelly Amy Nindia , Salsabila Karno Dhya Aurellia , Erlita Isyana , Trianuanty Aninditya Pimas
Published: April 2022

Introduction: Dual-species biofilm of Streptococcus mutans and Lactobacillus acidophilus in dental caries has a higher viability or ability to survive in comparison to mono-species biofilm, consequently it is more resistant to antibiofilm. Mauli banana stem gel (MBSG) contains isoleucine, cinnamic acid, and another bioactive constituents that may work as antibiofilm, hence it is able to decrease the viability of dual-species biofilm of S. mutans and L. acidophilus. This research aims to analyze the effect of MBSG on viability of dual-species biofilm of S. mutans and L. acidophilus. Material and methods: This research is a true experimental research with post test only with control group design which divides dual-species biofilm of S. mutans and L. acidophilus into 12 groups with 4 replications. Group 1 are given 0.2% chlorhexidine gel (positive control), group 2 are not given any treatment (negative control), group 3 are the media control, and group 4-12 are given MBSG concentration of 6.25%, 12.5%, 25%, 37.5%, 50%, 62.5%, 75%, 87.5%, and 98%. Each group is incubated for 72 hours, afterward is given MTT reagent and read using a microplate reader. Results: The result of Kruskal-Wallis (p=0,00) and Mann-Whitney test showed significant difference between all treatment groups and control groups. Conclusion: MBSG concentration of 6.25%, 12.5%, 25%, 37.5%, 50%, 62.5%, 75%, 87.5%, and 98% are able to decrease the viability of dual-spesies biofilm of S. mutans and L. acidophilus.
IN SILICO STUDY OF Stachytarpheta jamaicensis ACTIVE COMPOUNDS AS ANTIBACTERIAL MATERIAL
Authors: Putri Utami Juliyatin , Diana Sherli , Arifin Rahmad
Published: April 2022

Background: Stachytarpheta jamaicensis is a wild plant from the Verbenanceae family that grows in tropical areas such as Indonesia. S. jamaecensis extract was proven to contain secondary metabolite compounds such as flavonoids, phenols, saponins, tannins and terpenoids. The active compound of S. jamaecensis can be used as a drug candidate in the medicine field, especially as an antibacterial compound. One of the first steps in predicting the effectiveness of these compounds can be done through in-Silico studies with molecular docking. Objective: This study aims to evaluate the interaction of active compound S. jamaecensis with bacterial proteins through an in silico study. Methods: Using in silico method with computational docking analysis on seven active compounds of S. jamaecensis namely apigenin, luteolin, chlorogenic acid, gamma butyric acid, dopamine, ipolamide and geraniol, as well as two antibacterial drugs (metronidazole and chlorhexidine) as comparisons bound with bacterial cell wall protein, namely Glucosamine-6-phosphate synthase (G1mS). Docking in silico uses Autodock Vina, which is integrated with PyRx 8.0 and visualized using Discovery Studio Visualizer v19.1.0.18287 (2019 version) with data presentation based on docking scores. Conclusion: The best binding affinity score has been the luteolin-G1mS complex with a binding affinity value of -10.8 kcal/mol and was the highest value compared to the comparison ligand binding and the binding of other active compounds of S. jamaecensis.
THE CHANGES OF MANDIBULAR ROTATION AND LOWER ANTERIOR FACIAL HEIGHT IN DENTOSKELETAL ORTHODONTIC TREATMENT WITH MALOCCLUSION CLASS II/1 ANGLE
Authors: Parmasari Wahyuni Dyah , Willianty Enny , Theodora Theodora
Published: April 2022

Background: Classification of malocclusion, especially in the class II division, has various biological variations and dental abnormalities with the presence of distocclusion of the first molar relation and proclination of the maxillary fourth incisor and causing the patient's profile to become convex. Aesthetic correction in class II division 1 is determined by the choice of treatment and taking into account the rotational pattern of the mandible. Objectives: To determine the effect of orthodontic treatment in relation to changes in mandibular rotation with lower anterior facial height and to determine the parameters of the effect of mandibular rotation on lower anterior facial height (LAFH) in Angle Class II/1 dentoskeletal malocclusion. Methods: Cephalometric data were obtained from lateral cephalograms presented before and after treatment. Assessed changes in Y-axis FH angle, SN - mandibular plane angle (GoMe) and NPog-FH angle facial angle. Data analysis with Pearson was used to correlate the mandibular rotation parameter (angle) with the lower anterior facial height parameter, namely ANS-Me (linear) (p > 0.05). Results: Group 1 access maxilla, normal mandible showed a significant correlation on the Y-FH Axis with ANS-Me. Group 2 with normal maxillary, retrognathic mandibles, showed a significant correlation between NPog-FH with ANS-Me and NPog-FH with extrusion of the upper/lower first molars. Group 3, the combination group which is the maxillary retrognathic access, showed a significant correlation between Sn-GoMe and ANS-Me. Group 4 is with different teeth, but normal bone (grade 1). Conclusion: There is a relationship between changes in mandibular rotation and changes in lower anterior facial height (LAFH) in the orthodontic treatment of class II/1 Angle dentoskeletal malocclusion.
“Nature and Innovation”: Do appreciation of nature and need for cognition predict intentions to perform sustainable behaviors?
Authors: Muhiddin Syurawasti , Pertiwi Yopina Galih
Published: April 2022

Sustainable behavior is a behavior that aims to protect physical as well as human resources. Therefore, it is important to understand the behavior to reduce negative consequences of environmental problems. The study aimed to examine the role of appreciation of nature and the need for cognition on the intention to perform sustainable behavior. This study used a quantitative approach with a survey method. A total of 240 respondents aged 18 – 40 years old completed the online survey. Appreciation of nature scale, need for cognition scale, and intention to act scale were used as data collection instruments. Results showed that appreciation of nature and need for cognition positively predicted the intention to carry out sustainable behavior. Combining the two variables in one model increased predictive power to the intention to perform sustainable behavior. Furthermore, need for cognition had greater predictive power than appreciation of nature. This research showed that affective and cognitive aspects are crucial for the sustainable behavior models. Implications regarding the role of the young generation in supporting sustainable behavior may be further discussed.