bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of Entrepreneurship Development using ARAS
Method
Authors: Patil Vaishali
Published: January 2023

Entrepreneurship Development. The development of entrepreneurial knowledge and abilities through organized training programs is referred to as entrepreneurship. It focuses on the analysis of entrepreneurial behavior, business dynamics, and the development and growth of the latter. Entrepreneurship is the capacity and willingness to establish, plan, and manage a business enterprise along with all of its risks for financial gain. Starting new enterprises is the most well-known example of entrepreneurship. Entrepreneurs have advantages that extend beyond the companies they start. The lives of individuals, communities and the economy as a whole are all improved by entrepreneurs. Entrepreneurs are crucial in fostering social change and enhancing people's quality of life and employment. Increasing the knowledge and skills of current entrepreneurs and inspiring people to start their own businesses are the goals of entrepreneurship development programs. In the end, this contributes to the growth of this population within an economy. This paper is the Addition Ratio Assessment (ARAS) method. The ARAS method is also tested for the problems considered. All three methods are very simple to understand and easy to implement and are observed to provide almost perfect rankings for Entrepreneurship Development alternatives. Evaluation parameters on Agriculture, Mining, manufacturing, Electricity, gas & clean air supply, Construction, Trade, hotel & restaurant, Transport & Communication, Finance, rent & service, Services, and Small enterprises, Medium Enterprises, and Large Enterprises in this position. Agriculture, Mining, Manufacture, Electricity, gas & clean air supply, Construction, Trade, hotel & restaurant, Transport & Communication, Finance, rent & service, Services. Small Enterprise, Medium Enterprise, Large Enterprises. Trade, hotel & restaurant got the first rank whereas is Agriculture is having the lowest rank.
Dream Routes Intersecting; Shape of Water Shaping Rocky Banks
Authors: Newell Mary
Published: January 2023

.
Prognostic biomarkers for cardiovascular injury in patients with COVID-19: a review
Authors: Kanaeva T. V. , Karoli N. A.
Published: January 2023

Investigations into the causes of adverse outcomes of the novel coronavirus infection (COVID-19) have been ongoing since the beginning of the pandemic. There is evidence that coronavirus-induced cardiovascular injury is as important to a risk of adverse outcome as respiratory injury. Many studies have shown that concomitant cardiovascular disease aggravates the course of COVID-19. However, in some patients who did not have cardiovascular diseases before COVID-19, they are detected during hospitalization or after discharge from the hospital. The review examines data on the effect of serum biomarkers of cardiovascular disease determined during COVID-19 on the risk of adverse outcomes in the near and long-term follow-up periods. Among such biomarkers are considered: troponins, N-terminal pro B-type natriuretic peptide, creatine phosphokinase-MB, lactate dehydrogenase, myoglobin, growth stimulation expressed gene 2, pentraxin 3, angiotensin II, as well as D-dimer and homocysteine. Threshold values have been set for some of these biomarkers, which allow predicting the risk of an unfavorable outcome. At the same time, in most prognostic models, these markers are considered in association with cytokine storm indicators and other risk factors.
Predictors of surgical outcomes in patients with drug-resistant temporal lobe epilepsy
Authors: Shelyagin I. S. , Akimova P. O. , Stefanov S. Zh. , Sufianov R. A.
Published: January 2023

Aim. To identify predictors of surgical outcomes in patients with drug-resistant temporal lobe epilepsy in a multivariate model.

Materials and methods. Aretrospective study included 69 patients with drug-resistant temporal lobe epilepsy who underwent microsurgical anterior temporal lobectomy. The study included 31 (45%) men and 38 (55%) women. The median age was 28 (21; 36). Surgical treatment outcomes were assessed at 6, 12, 36, and 60 months after surgical intervention according to the Engel Epilepsy Surgery Outcome Scale. Logistic regression equations were calculated, a ROC curve was constructed, and odds ratio (OR) with 95% confidence interval (CI), sensitivity, specificity, area under the ROC curve (AUC) were calculated.

Results. In all assessed time periods, 88.3–93.0% of patients had outcomes consistent with Engel classes I and II. The distribution of patients by outcome classes did not change statistically significantly over the entire follow-up period. There were the following predictors of high efficacy of surgical treatment at 6 months after surgery: relatively shorter duration of active disease course (OR 0.719, 95%, CI: 0.437–0.966, p < 0.05), absence of status epilepticus (OR 0.048, 95% CI: 0.002–0.472, p < 0.05), absence of subdominant foci of irritative activity (OR 0.123, 95% CI: 0.012–0.845, p < 0.01), presence of mesial temporal sclerosis (OR 1008, 95% CI: 21.59–1310851, p < 0.01), a relatively longer resection margin on the temporal lobe (OR 637.32, 95% CI: 5.43–1960062, p < 0.05), lateralization of epileptogenic zone in subdominant hemisphere (OR 0.103, 95% CI 0.004–0.937, p = 0.0532). AUC was 0.957 (0.917–0.997), p < 0.0001; sensitivity 87.5%, and specificity 82.8%.

Conclusion. Independent predictors of the efficacy of microsurgical anterior temporal lobectomy in patients with drug-resistant temporal lobe epilepsy are the following: shorter duration of active disease course, absence of status epilepticus in the history, absence of subdominant foci, presence of mesial temporal sclerosis, a relatively longer resection margin on the temporal lobe, and lateralization of the epileptogenic zone in the temporal lobe of the subdominant hemisphere.
Cytokine profile of gingival crevicular fluid in children with impaired immunological surveillance system
Authors: Kozlitina Iu. A. , Admakin O. I. , Morozova N. S. , Zakharova N. B. , Morozova O. L.
Published: January 2023

Aim. To study the cytokine profile of the gingival crevicular fluid (GCF) in children with a juvenile rheumatoid arthritis (JRA).

Materials and methods. We examined 20 children with JRA and 10 patients without somatic pathology aged 6 to 16 years old. The condition of periodontal tissues was assessed by periodontal indices – gingival index GI (Loe, Silness, 1963) and gingival bleeding index GBI. Biomaterial sampling from the gingival sulcus was carried out using special endodontic absorbent paper points. Enzyme immunoassay for IL-18, IL-10, IL-1ß, IL-1RA, MCP-1, VEGFs in the GCF was performed using the test kits of Vector-Best LLC (Novosibirsk, Russia).

Results. Mean GI index in the JRA group was 0.31 ± 0.10 and in the control group – 0.20 ± 0.05 (p < 0.05), mean GBI index – 19.90 ± 3.14 and 10.80 ± 2.60 respectively (p < 0.05), which was accompanied by a more pronounced degree of inflammation of periodontal tissues. The GCF concentration of IL-18 in the JRA group was 6.70 (4.97–7.92) pg/ml, in the control group – 11.25 (8.70–13.10) pg/ml (p < 0.05), while the concentration of IL-1ß was 15.30 (13.79–17.18) pg/ml in the JRA group and 5.36 (5.32–5.54) pg/ml in the control group.

The IL-10 concentration in the JRA group was 3.60 (2.89–4.45) pg/ml, which was comparable to the values of the control group. The concentration of IL-1RA was lower in the JRA group than in the control group: 3638.5 (2397.5–4133.5) pg/ml and 4951.0 (4303.0–5455.0) pg/ml respectively. The total GCF chemokine concentration for MCP-1 was determined at the level of 15.65 (14.15–17.39) pg/ml and 15.50 (12.80–21.20) pg/ml for the main and control groups and for VEGF – 49.60 (41.95–54.50) pg/ml in the JRA group and 12.00 (11.00–13.00) pg/ml in control group.

Conclusion. In children with juvenile rheumatoid arthritis, an imbalance of pro- and anti-inflammatory cytokines in GCF plays a role in the development of gingivitis: an increased of IL-1ß concentration – a triggering factor of pro-inflammatory chains, a decreased concentration of IL-1RA – an anti-inflammatory cytokine, an increased concentration of VEGF – a marker of hypoxia.
Chronic heart failure with preserved ejection fraction: optimal therapy. Literature review
Authors: Kuzmenko A. A. , Sokolova A. A. , Napalkov D. A.
Published: January 2023

The literature review discusses approaches to the treatment of patients with chronic heart failure and preserved ejection fraction (EF>50) – HFpEF. The impact of various groups of drugs on the prognosis and quality of life of patients in this cohort was assessed based on the results of randomized trials, systematic reviews and meta-analyses, clinical recommendations of recent years. To date, only sodium-glucose cotransporter-2 inhibitors unequivocally improve the quality of life and prognosis of patients with HFpEF. Angiotensin receptor – neprilysin inhibitors and mineralocorticoid receptor antagonists are effective in terms of prognosis and quality of life only in patients with HFpEF in combination with resistant hypertension. In patients with sinus rhythm, heart rate > 70 beats/min and concomitant coronary artery disease, a combination of bisoprolol and ivabradine may be considered. Diuretics are recommended for patients with HFpEF when there are signs of congestion and signs of decompensation. Other groups of drugs do not significantly affect the quality of life and prognosis of patients with HFpEF and can be prescribed to such patients only as part of planned therapy for the treatment of other concomitant cardiovascular diseases.
Management of Chemotherapy-Induced Nausea and Vomitting in Breast Cancer Patients: A Prospective Cohort Study
Authors:   Mohammed VI University of Health Sciences, Casablanca, Morocco, Benali Imane , Mahfoud Tarik ,   Cheikh Khalifa International University Hospital, Casablanca, Morocco, Alidrissi Najib ,   Radiotherapy Department, Cheikh Khalifa International University Hospital, Casablanca, Morocco
Published: January 2023

Through a prospective cohort study we aimed to optimize prevention and management of chemotherapy-induced nausea and vomiting (CINV) in the emergence of new therapies for breast cancer patients. We included breast cancer patients treated with moderate emetogenic (MEC) or highly emetogenic chemotherapy (HEC) all stages combined, from April 2021 to November 2021. Patients were required to answer a survey of 32 questions in order to analyze the potential involvement of known and unknown risk factors in the occurrence of CINV. The acute phase of CINV was defined as nausea and vomiting that developed ≤ 24 hours after the start of chemotherapy. Delayed phase of CINV was defined as nausea and vomiting that developed > 24 hours after the start of chemotherapy. The severity of nausea and vomiting was evaluated with common terminology criteria for adverse events (CTCAE) v5.0; publish to date: November 27, 2017. Analysis and results were performed using JAMOVI statistical software. In total, 177 patients received chemotherapy, 103 patients(58%) received (HEC), and 74 patients (42%) received (MEC). All patients were female (100%). Risk factors associated to occurrence of CINV included previously known factors: Younger age than 50 years (29,8%), history of pregnancy-related nausea and vomiting (74,7%), alcohol use (no patient reported previous alcohol consumption), failure to adhere to antiemetic treatment guidelines (9,6%). The compliance with treatment score (90,4%) showed a good commitment of the patients in the process of their medical healthcare. Other potential risk factors have been also explored to determine their involvement or not in the occurrence of CINV (cancer stage, performance status, education level, chemotherapy protocols, the use of traditional herbs known as an antibacterial agent and immunity booster in our context). In the acute phase, (78%) of patients experienced nausea and (47,8%) experienced vomiting. In the delayed phase, (37,1%) of patients experienced nausea and only (15,3%) experienced vomiting. The severity of nausea and vomiting was evaluated according to CTCAE v5.0 in both groups HEC and MEC. Only (8,7%) had to stop treatment for non-tolerance (table 1-2). The present study demonstrated that high compliance to treatment guidelines for CINV and individualized care could lead to more optimal management of CINV.
Case Presentation MEN2A
Authors:   King Salman Armed Forces Hospital, Saudi Arabia, Rayyan Hazem , Alawi Yousof Al ,   King Salman Armed Forces Hospital, Saudi Arabia
Published: January 2023

Multiple endocrine neoplasia type 2 (MEN2) is an autosomal dominant disorder that can be distinguished as three different syndromes: multiple endocrine neoplasia type 2A (MEN2A). MEN2B and familial medullary thyroid carcinoma (FMTC). This disorder is usually caused by the mutations of the rearranged during transfection protooncogene gene (RET) or the neurotrophic tyrosine kinase receptor type 1 gene (NTRK1).
A note on radionuclide 137Cs and 40K concentrations in Dall’s porpoises, Phocoenoides dalli, in coastal waters of Japan
Authors: Kasamatsu F. , Kawabe K. , Inatomi N. , Murayama T.
Published: January 2023

Concentrations of artificial radionuclide 137Cs and natural radionuclide 4°K in Dall's porpoise, Phocoenoides dalli, from the Pacific coast of northern Japan in 1996 are presented. Concentrations of 137Cs in muscle tissue from two male Dall's porpoises were 0.153 ± 0.01 l and 0.234 ± 0.016 Bq kg-1 wetweight, and those of4°K were 104.0 ± 0.3 and 107.8 ± 0.9 Bq kg-1 wet weight, respectively. Concentration factors (CF, concentration in animal/concentration in sea water) for the two porpoises are 59 and 90 for 137Cs, respectively. These concentrations and CF values are within published ranges for marine fish in coastal waters. The CFs obtained in this study suggest that the trophic position of Dall's porpoises is similar to that of the large piscivorous fish in the marine community in coastal waters of Japan.
Using simultaneous counts by independent observers to correct for observer variability and missed sightings in a shore-based survey of bottlenose dolphins, Tursiops truncatus
Authors: F. YOUNG ROBERT , PEACE SALLY
Published: January 2023

Simultaneous counts by independent shore-based observers have been used to generate revised population estimates for gray and bowhead whales, but no similar technique has been applied to shore-based dolphin surveys. Shore-based whale surveys generally rely on a single observation site from which migrating whales are counted as they pass in one direction over a period of weeks to months. Shore-based dolphin surveys, however, typically use multiple observation sites over a much shorter time period (hours) in order to avoid double counting individuals as they change direction. This paper reports on a new technique to correct for observer variability and missed sightings for coastal bottlenose dolphin surveys conducted at Myrtle Beach, South Carolina, USA. Comparisons were made between concurrent counts by 39 pairs of independent shore-based observer teams. A model was developed to revise observer estimates in which the number of observed dolphin groups was multiplied by a correction factor to estimate the true number of groups, and this number in tum was multiplied by the mean group size to determine the total number of dolphins. The true number of dolphin groups was estimated using a modified Petersen mark-recapture estimate, stratified by group-size category. The mean proportion of groups missed by observers was negatively correlated with reported group size: 32.7% for groups of 1-2 dolphins; 16.5% for groups of 3-4 dolphins; and 9.9% for groups of >4 dolphins. A variability factor was also calculated to determine a confidence interval for the average number of dolphins per group, based on the mean percent difference between paired observer teams, stratified by group size. The model was used to calculate revised estimates for shore-based bottlenose dolphin surveys conducted in South Carolina in 1994 and 1995. The original uncorrected abundance estimates were increased by a factor of 1.14 and 1.19 respectively, comparable to similar calculations from shore-based surveys of gray whales. However, the estimated confidence interval of± 38% of the revised estimates is approximately four times the magnitude found in the gray whale studies. This difference is primarily due to the large observer variability for estimated dolphin group size and can be reduced using various revisions of survey design and methodology. Ideal conditions for this technique include elevated observer posts and accurate estimates of the proportion of the population within visual range of the coastline. This study demonstrates that shore-based dolphin surveys are a potentially efficient census technique and an attractive low cost alternative to aerial and boat surveys.
Producción de panela en el Cantón Atahualpa, Ecuador. Un acercamiento al cumplimiento de la tributación
Authors: Chávez Cruz Robert , Heras Garzón Josellin , Echeverria Bravo Carolina
Published: January 2023

El cultivo de la caña de azúcar y la producción de panelas, es una de las principales actividades económicas de la Parroquia Ayapamba, en el Cantón Atahualpa, por lo que con esta investigación se pretende examinar el cumplimiento tributario por parte de los productores. Para ello, se aplicó una guía de entrevista con siete preguntas y un cuestionario de 16 preguntas de selección, dirigidos a los pequeños productores de la región para conocer las actividades que realizan, sus conocimientos tributarios y razones por la desaparición de moliendas. De manera que, este trabajo descriptivo ameritó un procesamiento de la información de tipo cuantitativo por lo que se utilizó el análisis de contenido y la estadística descriptiva para el tratamiento de las respuestas obtenidas y la contrastación con autores como Bárcenas (2021), Benítez, et al. (2022) y Cárdenas (2019, entre otros. Los resultados del análisis constataron la falta de conocimiento en sus obligaciones tributarias por lo que afecta a su crecimiento económico, y a la vez se entiende el hecho de la desaparición de las moliendas de la producción de panela como consecuencia de la minería y altos costos de materiales y mano de obra que no justifica el precio de venta actual.
Determinantes de la oferta exportable del café en Nicaragua
Authors: Aviles Peralta Yader , Alfaro Blandón Miriam , Palma Juárez Lucía , Pérez Franco Mairena
Published: January 2023

El cultivo del café es fundamental para la economía de Nicaragua, por su generación de ganancias a través del comercio internacional y ser la base productiva de miles de pequeños y medianos productores; en el 2015 el café representó el 15.6% del total de exportaciones en el país. Este estudio realiza un modelo econométrico log-lineal de regresión múltiple con rezagos distribuidos sobre la oferta exportable de café en el periodo 1994-2015 y se sustenta en autores como Moguillansky (1995); Mántey (2013); Amaya y Lanuza (2014); Aviles, et al. (2020). La metodología utilizada es cuantitativa, correlacional y se incluyen variables como la política cambiaria, política comercial y la capacidad productiva (rendimiento y Producto Interno Bruto PIB). Los datos fueron extraídos del Banco Central de Nicaragua BCN y se utilizó el software econométrico Gretl para las estimaciones. Los resultados demuestran un modelo significativo (p=0.00) con variables independientes estadísticamente significativas que ajustan en un 89.5%. Se encontró que la apertura comercial rezagada en dos años tiene un efecto marginal positivo de 0.9% hacia la oferta exportable de café en el país, es decir, los tratados comerciales tienden a tener efectos dos años posteriores a su firma; respecto a la política cambiaria, el parámetro resultó ser menor con el 0.012% con un periodo de rezago, cumple con el signo esperado lo que explica que depreciar la moneda nacional influye en el aumento de las exportaciones en volúmenes el año siguiente pero con resultados bajos. El PIB y el rendimiento promueven leves incrementos de la oferta exportable.
Estrategia y proceso organizacional para la administración del capital de trabajo en la pyme
Authors: Briceño Nuñez Chess , Duran Sanchez Yosmary , Montilla Soto Alen
Published: January 2023

El gerente de una organización debe poseer ciertas habilidades, destrezas y competencias para manejar no sólo el trabajo a su cargo, sino lo más importante que tiene una organización, el personal que allí labora, pues es calificado como el motor fundamental para el desenvolvimiento de la misma. Por lo tanto, por considerarse el capital de trabajo como un elemento para operar en una empresa, se requiere de estrategias y procesos organizacionales viables que permitan alcanzar ventajas competitivas, de esta manera, lograr el desarrollo organizacional y manejar la complejidad que encierra el mundo de los negocios. El presente artículo –resultado de una investigación en que se utilizó una metodología de análisis documental, bajo un enfoque analítico-sintético– tiene como propósito analizar la estrategia y el proceso organizacional para la administración del capital de trabajo en la Pyme venezolana como una ventaja competitiva. Se llegó a la conclusión que las estrategias y el proceso organizacional son esenciales para una eficiente gestión del capital de trabajo, por consiguiente, para el funcionamiento y operatividad de las Pyme venezolanas, contribuyendo al sostenimiento de la organización, así como también al desarrollo del país.
Clima organizacional durante la pospandemia: Estudio del área administrativa en una empresa del sector logístico
Authors: Parra Fernández Margel , Ramírez Javier , Gutiérrez Carbonell Carlos , Piamba Bustamante Gesner
Published: January 2023

El clima organizacional es uno de los elementos más importantes en el abordaje y comprensión de las dinámicas laborales que suceden dentro de las empresas en la actualidad; especialmente durante la época de la postpandemia en Colombia a partir del fin del confinamiento. Con base a ello, este estudio se presenta con el objetivo de medir el Clima organizacional del área administrativa de una empresa del sector logístico de la ciudad de Barranquilla (Colombia). En el ámbito metodológico, se destaca que la mencionada investigación se desarrolló desde el enfoque positivista, siendo un estudio de tipo descriptivo con un diseño no experimental y de campo. La muestra estuvo constituida por 46 trabajadores de una empresa del sector logístico de en la ciudad Barranquilla, a quienes se les aplicó un instrumento desarrollado por Litwig y Stringer. Los resultados permitieron observar niveles considerados como desfavorables del clima organizacional dentro de la organización, especialmente en las dimensiones Estructura, Responsabilidad, Recompensa, Riesgo, Calidez, Apoyo y Conflicto. Se concluye que en estos casos de una percepción desfavorable es recomendable la puesta en marcha de estrategias encaminadas a la intervención del clima organizacional, comenzando por una auditoria estructural sobre las dimensiones con resultados más bajos.
Ўзбекистон Республикасининг давлат герби: тарихий йўл ва ҳозирги кўриниши
Authors: Muxammadiev Raxmon
Published: January 2023

Ушбу мақолада Ўзбекистон Республикаси давлат гербининг қабул қилиниши, унинг яратилишигача бўлган тарихий йўл, жумладан, Ўрта Осиёни Россия империяси томонидан босиб олингандан кейин яратилган вилоятлар герблари, Бухоро халқ совет республикаси ва Хоразм халқ совет республикаси герблари, совет ҳокимияти йилларида амалда бўлган Туркистон АССР герби ва Ўзбекистон ССР гербининг яратилиши, мустақил Ўзбекистон давлат гербининг қабул қилиниши, унда халқнинг тарихий ўтмиши ва республика хўжалигининг акс этиши, тасвирларнинг ўзига хос рамзий маънолари ҳақида маълумот берилган.
Использование интернет-ресурсов в учебно-тренировочном процессе шахматистов
Authors: Норбоев Набижон
Published: January 2023

Сегодня уже ни у кого не вызывает сомнения, что полноценная подготовка шахматистов не может производиться без использования интернет-технологии, а квалифицированный шахматист должен свободно ориентироваться в просторах Интернета и уметь эффективно использовать его возможности в своей профессиональной деятельности. Исследования свидетельствуют, что использование сети Интернет способствует развитию мышления, предоставляет новые средства для решения творческих задач, изменяет стиль умственной деятельности. В сочетании со стремительным развитием информационных технологий и виртуальной реальности, Интернет открывает новые возможности в представлении учебного материала, повышении степени мотивации и самостоятельной подготовки, реализации индивидуального подхода в подготовке шахматиста. Все это вместе обеспечивает условия для усовершенствования умений и знаний шахматистов. В статье рассматривается использование шахматных интернет-ресурсов в учебно-тренировочном процессе шахматистов. Рассмотрен вопрос анализа шахматных интернет-ресурсов и перспектив их использования в учебно-тренировочном процессе шахматистов. Сделан анализ шахматных сайтов и предложена их классификация.
Implementasi Pembelajaran Blended Learning Dalam Pembelajaran Jarak Jauh Pada Masa Pendemi Covid-19 Di SMK Negeri 2 Lahat
Authors: Pratama Sepri , Syah Lin Yan , Fitriya Fitriya
Published: January 2023

Walaupun pandemi covid-19 mewabah di seluruh dunia tidak terkecuali di Indonesia, namun pendidikan tidak boleh berhenti. Penelitian ini bertujuan untuk mengetahui Implementasi kegiatan pembelajaran Blended Learning dalam Pembelajaan Jarak dan untuk mengetahui apa saja yang menjadi factor penghambat dan pendukung pada penerapan pembelajaran berbasis Blended Learning di SMK Negeri 2 Lahat. Jenis penelitian yang digunakan dalam penelitian ini adalah field research dengan pendekatan kualitatif. Variabel yang digunakan dalam penelitian ini yaitu variable tunggal (implementasi blended learning. Penelitian ini dilaksanakan di SMK Negeri 2 Lahat. Narasumber penelitian ini antara lain Kepala Sekolah, Guru dan Siswa SMK Negeri 2 Lahat. Narasumber yang di wawancara adalah kepala sekolah, guru dan juga siswa berdasarkan kriteria. Hasil penelitian diperoleh menunjukkan pelaksanaan metode Blended Learning dilakukan secara asinkron mandiri berbasis online, adapun mata pelajaran kejuruan seperti TKJ (Teknik Komputer dan jaringan), OTKP (Otomatisasi dan Tata Kelola Perkantoran, TBU (Tata Busana) , AKL (Akuntansi Keuangan dan Lembaga) (AKL), TBO (Tata Boga) dan BDP (Bisnis Daring dan Pemasaran) dilakukan secara tatap muka disekolah. Faktor penghambat dan pendukung. Dalam penerapan metode blended learning, beberapa factor penghambat yaitu pembelajaran online (koneksi internet yang tidak stabil dan cenderung satu arah), dukungan SDM yang kurang optimal, Evaluasi sistem pembelajaran yang belum maksimal. Sedangkan factor pendukung dalam pelaksanaan metode blended learning yaitu adanya dukungan dari pemerintah, peran guru dalam membimbing siswa, lokasi atau wilayah dalam zona aman
Towards a Collaborative Learning Framework for D-learning based on improving the teamwork skills of adolescents
Authors: Martínez-Venegas Liliana
Published: January 2023

Collaborative learning (CL) and Computer Supported Collaborative Learning (CSCL) are educational models that significantly improve students' higher-order, digital, and transversal skills if employed appropriately. Experts and industry members have named the CL and CSCL essential strategies to solve the deficiencies detected in the skills of professionals working in a digital economy profoundly accelerated by technological advances and the consequences of the COVID-19 pandemic. This document presents a project’s path and current status to create a framework for collaborative learning among adolescents, focused on developing their team skills and robust support in the principles of d-learning. This research seeks to formulate a model for face-to-face learning at first, but that can evolve to be implemented in both online and hybrid courses.
Usability Test of a Virtual Reality System focused on Elderly people with Postural Instability
Authors: Montejano Salvador , Rocha Aaron J. , Barboza Bruno , Jauregui Ignacio
Published: January 2023

In this work, a usability analysis will be conducted to a virtual reality system which will be used as an aid in the physical therapy treatment of patients who live with postural instability caused by their age. The system must present some design features to allow for easy interaction and understanding of the activities to increase the likelihood of reaching the physical therapy objectives. During the evaluation, 37 heuristics focused on virtual immersion environments will be used, and some playability tests paired with post-test interviews will be conducted. The goal is to design a system that will help reduce the possible negative effects that are normally associated with the use of virtual reality since they can cause physical discomfort or reduce the efficacy of the treatment that patients must follow. In this document, the case study, the testing method, and the design of the tools used for the tests are presented.
A critical reflection on the treatment of AI system’s 'agency' in the (Spanish) media
Authors: Guersenzvaig Ariel , Sangüesa Ramon
Published: January 2023

For some time now the reception and communication of the achievements of artificial intelligence systems in the media seem to revolve around a number of similar tropes and rhetorical structures. The attribution of 'agency' and intention to the artificial systems created, the granting of superhuman powers to these systems, and the supposedly logical consequence of the elimination of domains in human practice are some of the common points in these reports on the media. Recent cases related to DALL-E and GPT-3 are analyzed and commented on in this paper. Several problems related to hyperbolic and misplaced reporting are discussed.
Multimedia Principles Applied to a Virtual Reality Application Design for Procedural Learning
Authors: Bautista Luis Eduardo , Guerrero José , Plata Carmen
Published: January 2023

Designing immersive learning environments based on simulations has evolved into a tool for practicing procedures in fields such as industrial safety. This document describes the design of a virtual reality learning environment for the practice of safe bench saw use in the carpentry workshops of the Industrial Design Program at Universidad Industrial de Santander (Colombia). The user interface was created using the multimedia principles of spatial contiguity, temporal contiguity, redundancy, and signaling from the Four-Components Instructional Design Model. The qualities mentioned have ties to the 4C/ID model's elements, learning tasks, procedural information, support information, and practical tasks, which allowed for their incorporation into the user interface elements of a virtual reality environment. A design for evaluating the prototype is also presented in order to assess how well it performs in terms of teaching students who use the learning environment how to use the machine safely.
Augmenting interoceptive awareness with off-the-shelf sensors using visuo-haptic emotional stimulus
Authors: Dollack Felix , Ait Baali Hoda , Cuberos Balda Marisabel , Gomanne Luc , Paez-Granados Diego , Perusquía-Hernández Monica , Salazar Luces Jose Victorio , Gómez Jáuregui David Antonio
Published: January 2023

Wearable sensing technologies allow us to monitor and track a wealth of information about bodily states. Tracking applications rely on abstract numerical or graphical visualizations to make this information accessible to us. However, these visualizations can be hard to interpret, and even be harmful to already vulnerable groups. Hence, we propose to give feedback in the form of an enhanced heart rate interoception and an embodied artificial agent. This method relies on the person’s inherent understanding of their own body. It is a subtle and more natural way to gauge the meaning of off-the-shelf sensors’ feedback. A wearable pet prototype that presents emotion through visuo-haptic feedback is evaluated in a match and a mismatch group. Participants in both groups answered self-report and perceived affect of the interoceptive feedback without significant differences. However, the groups’ perceived closeness to the pet differed significantly.
Dialog modeling of domain specific cognitive assistants
Authors: Ramos Díaz J. Guadalupe , Ruiz Lagunas Juan Jesús , Núñez Vieyra Adrián , Cuin Jacuinde José Manuel , Olivares Rojas Juan Carlos
Published: January 2023

Intelligent virtual assistants of software are becoming more common. Frequently, the communication interface is dialogue which is expressed in natural language. When an assistant consists of questions that are associated with a single answer, the abstraction of the dialogue is straightforward, however, when there are conversations with multiple bifurcations in the flow of communication, the representation and documentation is complex. In this sense, there is a lack of formalities that allow a dialogue to be accurately represented and based on them, to proceed with its programming in an industrial framework. In this work we propose the use of finite state machines to model complex dialogues. Thus, we introduce a formal model for the representation of dialogue and its mapping to a real assistant, using an industrial framework. We believe that our approach will make it easier to design and to program assistants with complex interaction, enabling better adoption of them.
Using design thinking process to design an electronic Kardex: a case study from a self-access center
Authors: Falfán-Hernández Luz Marisol , Hernández-Calderón José Guillermo , Montané Jiménez Luis Gerardo
Published: January 2023

A self-access center is a space that allows the development of a self-learning process and in which English and French language courses are taught in different modalities such as: face-to-face, autonomous, or virtual. This work describes the application of the design thinking process to produce and evaluate the design of an electronic (online) kardex that helps to facilitate the management of all the activities and keep track of students’ progress in a self-access center.
Neutropenic Enterocolitis: Case report and literature review
Authors: Gutierrez Castillo Aldo , Bellido-Caparó Alvaro , Gallegos-Serruto Guido , Tagle Martin , Hernandez Jose
Published: January 2023

Typhlitis, is also known as neutropenic enterocolitis, affects the cecum and distal ileum. It was frequently encountered in pediatricpatients who were undergoing treatment for leukemia. Nonetheless, it can affect adult patients, regardless of the cause of the immunosuppression. We report the case of a 20-year-old patient who was receiving chemotherapy for Osteosarcoma, who had a 6-day history of nausea and vomiting, fever sensation, diarrhea, and diffuse abdominal pain. Physical examination was relevant for hemodynamic instability, a distended and tender abdomen predominantly in the right iliac fossa. The laboratory workup showed severe neutropenia, thrombocytopenia, and electrolyte disturbances. The image studies evidenced edema of the ascending colon and cecum. Treatment was started with vasopressor support, correction of electrolyte alterations, blood cell and platelet transfusion, G-CSF, hydration, broad spectrum antibiotic therapy, initially with adequate clinical and laboratory response. After a few days, he presented lower gastrointestinal bleeding which was treated by conservative management. In conclusion, typhlitis must be suspected in every patient developing neutropenia as a reaction to chemotherapy and who also presents gastrointestinal symptoms, such as nausea, vomiting, diarrhea, and intense abdominal pain.
Presencia de ansiedad y depresión en pacientes de consulta externa de gastroenterología en Lima Metropolitana
Authors: Saavedra Farach Mariella , Astuquipan Barrientos Hannia Pamela
Published: January 2023

Los objetivos fueron identificar la presencia de ansiedad y depresión en pacientes que acuden a consultorio externo de gastroenterología en la ciudad de Lima y describir los antecedentes gastroenterológicos y síntomas más relacionados a estos trastornos. La muestra estuvo conformada por 200 pacientes adultos pertenecientes a 32 distritos de Lima Metropolitana, atendidos por la especialidad de Gastroenterología en la modalidad de consultorio externo durante marzo a octubre del 2021, a quienes se les aplicó la Escala de Ansiedad y Depresión Hospitalaria (HADS) adaptada por Vilela. El estudio fue descriptivo-correlacional y la muestra prospectiva. Alrededor de 1 de cada 2 pacientes (49%, n=98) presentó ansiedad, 1 de cada 5 (19%, n=38) depresión y 16,5% (n=33) concomitantemente ambos trastornos. Los antecedentes gastroenterológicos de Dispepsia (v=0,216) y Síndrome de Intestino Irritable (v=0,188) mostraron asociación estadística para ambas variables. Diarrea (v=0,214) y dolor torácico (v=0,215) fueron síntomas asociados a ansiedad, así como dolor torácico, con depresión. Los trastornos de ansiedad y depresión tienen alta prevalencia en la población que acude a consulta externa, sugerimos explorar dichas variables y ofrecer un abordaje multidisciplinario a los pacientes atendidos por esta modalidad.
Tricobezoar gástrico: reporte de un caso y revisión de la literatura
Authors: Huaco Aranguri Alejandra Ana De Jesus , Orduña Carpio Rosa Alessandra , Ortiz Castro Carlos Alfredo , Delgado Gonzales Marco Antonio , Haito Chávez Yamile
Published: January 2023

El bezoar gástrico es una tumoración por cuerpo extraño que resulta de la acumulación de material no digerible en el estómago. El tricobezoar es uno de ellos y frecuentemente se presenta en la población femenina joven que padece trastornos psiquiátricos. La presentación del bezoar gástrico es insidiosa e inespecífica, teniendo un curso inicialmente asintomático por años, hasta que alcanza un tamaño que evidencia síntomas. El método diagnóstico de elección es la endoscopía, ya que permite visualizar el bezoar y plantear el tratamiento. El abordaje terapéutico estará determinado por el tipo, tamaño y consistencia de este; sin embargo, la resolución quirúrgica es la de elección, la cual siempre debe estar asociada a tratamiento psiquiátrico para prevenir la recurrencia del cuadro. Se presenta el caso de una paciente de 19 años con el diagnóstico de tricobezoar gástrico, asociado a tricotilomanía y tricofagia como patologías de fondo, y se realiza una revisión de la literatura.
Pancreatitis aguda asociada a balón intragástrico
Authors: Chirinos Vega Juan Antonio , Cabrera-Hinojosa Dacio Hector
Published: January 2023

Presentamos el caso de una mujer joven con el hábito de dormir en posición decúbito ventral, quien refiere que, tras la colocación de balón intragástrico, inició cuadros repetitivos de dolor abdominal en epigastrio, de aparición nocturna. El más reciente se caracterizó por dolor abdominal súbito e intenso, elevación de enzimas pancreáticas y hallazgos imagenológicos compatibles con pancreatitis aguda. Tras realizar un estudio etiológico sistemático, se descartan otras causas, retirándose el balón intragástrico con inmediato cese de los dolores nocturnos. Se atribuyó la etiología a fenómenos de compresión mecánica provocados por el balón sobre el cuerpo pancreático durante el descanso en decúbito prono. Hacemos notar que el hábito de reposo en la posición decúbito ventral constituiría un potencial factor de riesgo para pancreatitis post-colocación de balón intragástrico, por lo que este factor debe ser tomado en cuenta en la orientación de los candidatos a esta técnica.
Experiencia en colangioscopia digital peroral con SpyGlass DS en diferentes centros de referencia en gastroenterología y endoscopia digestiva en Colombia: Serie de casos
Authors: Flórez Sarmiento Cristian , Parra Izquierdo Viviana , Frías Ordoñez Juan Sebastian , Parga Bermúdez Julián , Castillo Jesús David , Stefani Rodríguez Charlyn , Rodríguez Víctor
Published: January 2023

SpyGlass DS es un sistema de colangioscopia peroral, asociado a mejor calidad de imagen y configuración. Actualmente, existe diversidad en su uso y escasa información sobre su implementación, incluyendo resultados clínicos y eventos adversos. Describir la experiencia de uso del SpyGlass DS en varios centros de referencia en gastroenterología en Colombia, mencionando eficacia y posibles eventos adversos. Este es un estudio observacional (serie de casos). La principal indicación fue coledocolitiasis (n:204), seguida de estenosis biliar (n:40) y pancreatolitiasis (n:16). 49,2% fueron hombres, edad media de 58,6 años, clínicamente con predominio de dolor abdominal (80,5%) e ictericia (86,1%). Todos los casos presentaron diagnóstico por imagen previo (tomografía computarizada, resonancia magnética o ecografía), 98,07% colangiopancreatografía retrógrada endoscópica previa (n:255) y 75% stent plástico biliar. Se utilizó láser en 78/220 pacientes y litotricia electrohidráulica en 142/220 pacientes, con tasas de resolución en una sola sesión 96,15% y 95,07%, respectivamente. Siete casos requirieron segunda sesión de litotricia y 3 pacientes requirieron manejo quirúrgico, uno por pancreatolitiasis con páncreas divisum de base y 2 por hepatolitiasis. 40/260 pacientes presentaron estenosis biliar, 32/40 con hallazgos malignos (colangiocarcinoma) y 8/40 con patología benigna (colangitis esclerosante primaria, cambios inflamatorios inespecíficos) tras estudios histopatológicos. Como complicaciones, se registraron 6 casos de bacteriemia (2,5%), siendo más frecuentes en casos de estenosis. La estancia media postoperatoria fue 2,04 días. Concluimos que el uso del SpyGlass DS es factible en nuestro medio, siendo eficaz para diagnóstico y tratamiento de lesiones biliares, y con bajo riesgo de eventos adversos.
Esofagitis disecante superficial: entidad subdiagnosticada en pacientes pluripatológicos
Authors: Berrospi Castillo Diego , Kapsoli María del Carmen , Benites Goñi Harold E.
Published: January 2023

Paciente de 76 años con múltiples comorbilidades presenta sintomatología gastrointestinal, donde la endoscopía digestiva alta revela mucosa esofágica “acartonada” en tercio distal, que a la toma de biopsia se produce esfacelación de 20 mm de largo por 6 mm de ancho, con sangrado que se autolimita. Muestra patológica es compatible con Esofagitis Disecante Superficial (EDS). Esta es una entidad poco frecuente descrita por primera vez en 1800, caracterizada endoscópicamente por desprendimiento de mucosa en tiras verticales como “cinta de papel de regalo”, que se confirma mediante patología con una mucosa “bitonal”, compuesta por una capa superficial eosinofílica y una zona basofílica de apariencia normal. Puede estar acompañada de inflamación mínima focal. La etiopatogenia no es clara; sin embargo, tiene buena respuesta a inhibidores de bomba de protones (IBPs). En nuestro caso la paciente presentaba todas las características de EDS, y ante su baja frecuencia reportada, se realizó revisión de literatura y discusión de esta rara entidad.
Cribado de cáncer de páncreas en la práctica clínica: es el momento de la prevención
Authors: Adán-Merino Luisa , Mora-Soler Ana , Zaera-De la Fuente Celia , Garrido-Gallego Francisco , Crivillén-Anguita Olivia , Ponferrada-Díaz Ángel
Published: January 2023

El cribado de cáncer de páncreas en población de alto riesgo puede mejorar la supervivencia. Sin embargo, hay pocas referencias sobre su aplicabilidad y hallazgos en la práctica clínica habitual. Nuestro objetivo es evaluar los hallazgos de las pruebas de cribado de cáncer de páncreas en individuos de alto riesgo en la práctica clínica y describir las variables asociadas a la presencia de lesiones relevantes. Este es un estudio observacional prospectivo en el que se seleccionaron pacientes con alto riesgo de cáncer de páncreas, según los criterios del Consorcio Internacional de Cribado de Cáncer de Páncreas. Se analizaron variables demográficas, presencia de factores de riesgo de cáncer páncreas y los hallazgos de las pruebas. Posteriormente se compararon pacientes que presentan lesiones relevantes con aquellos sin hallazgos. De 70 pacientes de alto riesgo, 25 cumplieron los criterios de cribado. El síndrome hereditario más frecuente fue el cáncer de mama y ovario hereditario (60%). En once individuos (44%) se identificaron hallazgos y en tres (12%) fueron relevantes: dos tumores papilares mucinosos intraductales y un tumor sólido localizado. La mutación en BRCA2 fue la más frecuente en lesiones significativas (66,7% vs 30%, p=0,376) sin encontrar asociación con diabetes ni tabaquismo (0 vs 18 %, p=0,578 y 0 vs 4,5%, p=0,880 respectivamente). En conclusión, las pruebas de cribado permiten detectar lesiones en estadio precoz o resecables en un importante porcentaje de población de alto riesgo seleccionad entes pertenecientes al síndrome de cáncer de mama y ovario hereditario.
Kajian Relasi Desain Perancangan Ruang Tamu di Rumah Tinggal Modern Dengan Ruang dan Tempat Ketiga
Authors: Ibadi Mohamad Wisnu
Published: January 2023

Dalam kebudayaan masyarakat Indonesia, fungsi dan makna keberadaan ruang tamu sangat penting dalam kehidupan sosial. Namun saat ini ada fenomena ruang tamu dihilangkan dari program ruang desain perancangan rumah tinggal developer di kawasan perumahannya. Tulisan ilmiah ini melanjutkan dua publikasi ilmiah di Jurnal Arsitekta, dengan judul Kajian Perancangan Teras Sebagai Ruang Tamu New Normal di Rumah Tinggal dan Kajian Keberadaan dan Peran Ruang Tamu Dalam Desain Perancangan Rumah Tinggal Studi Kasus: Perumahan Tanglin Parc Bogor dan Grand Arla Resort Serang. Saat peneliti melakukan riset untuk publikasi ilmiah pertama, ditemukan fenomena hilangnya keberadaan ruang tamu dalam rancangan desain rumah tinggal di kawasan perumahan developer. Fenomena itu lalu dikaji di publikasi ilmiah kedua, dengan melakukan studi lapangan dua kawasan perumahan dari dua developer berbeda, dan wawancara, juga survei kuesioner kepada masyarakat umum, yang menunjukkan bahwa desain perancangan rumah tinggal modern di developer saat ini tidak lagi memiliki ruang tamu dalam program ruangnya dan responden kuesioner mayoritas lebih memilih melakukan pertemuan di luar rumah sehingga ruang tamu di rumah tinggalnya tidak lagi sering digunakan. Dalam diskusi dan kesimpulan tulisan ilmiah ini, hilangnya desain perancangan ruang tamu di rumah tinggal modern saat ini adalah karena pengaruh tempat ketiga (Third Place) dan ruang ketiga (Thirdspace).
Perbandingan Desain Ruang Isolasi Terhadap Jumlah Kuman Udara Di Ruang Isolasi (Studi Analitik Pada Ruang Isolasi Covid-19)
Authors: Wahyutomo Ridha
Published: January 2023

Meningkatnya perhatian pada infeksi di rumah sakit, terutama terkait penilaian akreditasi dan tujuan keselamatan pasien mendorong penyediaan fasilitas pelayanan termasuk desain ruang isolasi yang mengurangi risiko infeksi. Pemilihan desain ruang isolasi terutama di masa pandemi COVID-19 memerlukan pengawasan terhadap konsentrasi mikroba di udara dan kualitas udara ruang isolasi yang harus dilaporkan dan dianalisis untuk menyusun strategi dan kebijakan pengelolaan ruang isolasi.Secara keseluruhan, tujuan dari penelitian ini adalah untuk menganalisis hubungan antara desain ruang isolasi dengan jumlah kuman udara ruang isolasi COVID-19.Penelitian ini merupakan penelitian analitik dengan metode komparatif. Sampel penelitian merupakan udara di ruang isolasi COVID-19 RS Mardi Rahayu Kudus. Variabel penelitian meliputi suhu, kelembaban, aliran udara, dan jumlah bakteri udara menggunakan data primer hasil penilaian dan surveilans ruang isolasi dari bulan Januari sampai Maret 2020 di RS Mardi Rahayu Kudus. Analisis menggunakan Mann Whitney dan dilanjutkan uji regresi.Hasil menunjukkan tidak terdapat perbedaan signifikan antara jumlah kuman udara di ruang isolasi pada desain tipe S dengan jumlah kuman udara isolasi pada desain tipe N. Dari regresi didapatkan bahwa untuk desain tipe N maupun S, faktor suhu, kelembaban, dan ACH tidak berpengaruh terhadap jumlah koloni di ruang.