bluuebunny/crossref_metadata_2025 huggingface dataset:
Changes in Prosocial Behaviors Among Children With Behavioral Problems Following Incredible Years Parenting Program
Authors: Masiran Ruziana , Ibrahim Normala , Awang Hamidin , Ying Lim Poh
Published: May 2022

Parenting programs often train parents in improving their parenting practices and parent-child relationship to reduce behavioral problems in children. However, the children’s prosocial behaviors are less examined as an intervention outcome in these programs. This study aimed to evaluate the effectiveness of the Incredible Years parenting program (IYPP) for Malaysian parents of school-going children and its sustainability in improving the children’s prosocial behaviors. This randomized controlled study involved pre- and post-intervention assessments at 2 and 14 weeks. Mothers of children aged 6-12 years (n = 70) recruited through the pediatrics and the child and adolescent psychiatric clinics were randomly assigned to the parenting program or a waitlist control condition. The mothers rated their children’s prosocial behaviors using a self-administered questionnaire. The program ran two to three hours weekly for 14 weeks. Several modifications were made to the program to accommodate public health control during the pandemic. Children in the intervention group showed a notable but non-significant increase in prosocial skills. However, subsequent score decline at follow-up may suggest a lack of evidence that the program is potentially effective in improving prosocial behaviors among school children who are at risk of or already having behavioral problems.
Development and Reliability and Validity Test to the Parenting Stress Questionnaire for Two-Child Mothers
Authors: Zhang Zhinuo , Tang Yulong , Chen Xiyue , Lin Xinyi , Tao Jiaheng
Published: May 2022

China is getting old before it gets rich. Among women of childbearing age, there seems to be little interest in having multiple children, and parenting stress may be one of the reasons. There are differences in the parenting stress felt by mothers with one child and those with two, but there is no questionnaire specifically aimed at the parenting stress felt by mothers of multiples in China. The purpose of the present study is to develop and verify a questionnaire specifically aimed at measuring the stress of two-child mothers in the Chinese context. We chose mothers as participants who were younger than 50 years old and their second child were younger than 18 years old as participants. The initial questionnaire was created after analyzing the results of 83 participants’ open questionnaires and 16 participants’ qualitative interviews. Item analysis and exploratory factor analysis were conducted with 279 participants. The final questionnaire was created after conducting reliability and validity tests on the responses of 263 participants to 23 items on the questionnaire covering four factors: characteristics of mother, environmental factor, characteristics of child, and relationship between the two siblings. The results of confirmatory factor analysis indicated that the four-factor model fit well (χ2/df= 2.00, CFI = 0.91, TLI = 0.90, SRMR = 0.06, RMSEA = 0.06). McDonald’s omega coefficients and split-half reliability coefficients both ranged from 0.50 to 0.95. The questionnaire scores were significantly positively correlated with parental burnout, the regret of having a second child and parenting stress, and were significantly negatively correlated with the intention of having a third child and support for the three-child policy. Overall, the present study confirmed the reliability and validity of the parenting stress questionnaire for two-child mothers, which can be used to measure the parenting stress experienced by mothers of multiples in China.
Complex Shapes Are Bluish, Darker, and More Saturated; Shape-Color Correspondence in 3D Object Perception
Authors: Song Jiwon , Shin Haeji , Park Minsun , Nam Seungmin , Kim Chai-Youn
Published: May 2022

It has been shown that there is a non-random association between shape and color. However, the results of previous studies on the shape-color correspondence did not converge. To address the issue, we focused on shape complexity among a number of shape properties, particularly in terms of 3D shape, and parametrically manipulated the shape complexity and all three components of color. With two experiments, the current study aimed to closely examine the correspondence between shape complexity of 3D shape and color in terms of hue (Experiment 1), luminance, and saturation (Experiment 2). Participants were presented with the 3D shapes in either visual or visuo-haptic modes of exploration. Subsequently, they had to pick from a color palette the color best matching each shape of the object. In Experiment 1, we found that as shapes became more complex, the best associated hue changed from those with long wavelengths to ones with short wavelengths. Results of Experiment 2 demonstrated that as the shapes grew more complex, the associated luminance decreased, and saturation increased. Additionally, adding haptic exploration to visual exploration strengthened the association – for saturation in particular – with the pattern of shape-color correspondence maintained. Taken together, we demonstrated that complex shapes are associated with bluish, darker and more saturated colors, suggesting that shape complexity has a systematic relationship with color including hue, luminance, and saturation.
Information About Inequality of Opportunity Increases Downward Mobility Perceptions: A Population-Wide Randomized Survey Experiment
Authors: Gugushvili Alexi
Published: May 2022

Existing evidence which is primarily based on cross-sectional and observational data suggests that perceptions of doing worse or better than parents might be more important for various life outcomes than the conventional measures of mobility based on the objective indicators of socioeconomic position. In 2021, we commissioned a nationally representative survey in Georgia which included a population-wide randomized survey experiment. We confirmed the association between, on the one hand, perceived social mobility and, on the other hand, physical and mental health, satisfaction with life, and the perceived state of affairs in the country. More importantly, the experimental design allowed us to conclude that the perception of being downwardly mobile was causally determined by a short message shared with individuals that equality of opportunity in their country was low. Those who were given information that children’s socioeconomic position was strongly linked to their parents’ socioeconomic position were seven percentage points more likely than individuals in the control group to perceive themselves as being downwardly mobile. We extrapolate these findings to the broader context and argue that the messages about (in)equality of opportunity which individuals receive in their everyday lives might also shape their perceptions of social mobility in other countries.
A Theoretical Review on the Impact of EFL/ESL Students’ Self-Sabotaging Behaviors on Their Self-Esteem and Academic Engagement
Authors: Zhang Fuhua
Published: May 2022

Learner emotions have been considerably emphasized in SLA research and practice with the advent of positive psychology. This has led to a surge of scholarly interest in this strand of research over the past years all around the world. However, the impact of students’ negative emotions such as self-sabotage that actually occur in english as a foreign language (EFL) classrooms on the construction and development of positive learner emotions like self-esteem and academic engagement has been mostly overlooked by second/foreign language researchers. Against this shortcoming, the present review article presented the theoretical and empirical underpinnings of these three crucial variables in SLA focusing on their conceptualizations, dimensions, typologies, related studies, and research gaps. Finally, the study offers a number of practical implications to [EFL/english as a second language (ESL)] teachers, students, teacher trainers, and SLA researchers in order to increase their awareness of learner emotions and the power of such feelings in language teaching and learning processes.
Adoption of M-Learning in Business English Course and Its Relationship to Learning Style Preferences: An Empirical Investigation
Authors: Cao Xiaojun
Published: May 2022

Learning around the world has been changed with the rapid development in technology which promotes the students to be more flexible and interactive with each other which has been encouraged by the mobile learning environment. Therefore, the current study intends to analyze the impact of inquiry learning, reflective thinking on problem-solving skills, and critical thinking skills with the mediation of peer communication. To carry out the study, data was collected from 378 college students in China by using survey forms. The analysis of the data and validation of the proposed hypotheses were conducted using Smart-PLS and structural equation modeling (SEM) technique. The results revealed that inquiry learning and reflective thinking affect problem-solving skills. However, inquiry learning and reflective thinking did not affect critical thinking skills. Moreover, the study found that peer communication mediated the relationship between reflective thinking, problem-solving skills, and between reflective thinking and critical thinking skills. However, peer communication did not mediate the relationship among inquiry learning as independent variable and problem-solving skills and critical thinking skills as dependent. The study has theoretically contributed by examining the impact of online learning styles on higher-order thinking skill (HOTS) in the M-learning environment. Also, the study greatly advances the literature by investigating the mediating role of peer communication. Practically, the colleges can improve the students HOTS by devising policies and educational programs focusing on learning styles.
Role of Leadership in Adoption of Blockchain Technology in Small and Medium Enterprises in Saudi Arabia
Authors: Alshareef Nasser , Tunio Muhammad Nawaz
Published: May 2022

This research aims to determine the role of the leadership and potential benefits that blockchain adoption may bring to SME financing in the Kingdom, as well as the foreseeable challenges that may hinder small businesses from benefiting from the adoption of blockchain. It is interesting aspect to see how leadership manages to adopt new changes amid several challenges and threats. This article also outlines policy and regulatory trends that SMEs can save operating costs and improve efficiency, thereby increasing transparency and easier access to funds. Digital technology and creative business models have the potential to help narrow the financing gap for SMEs. E-commerce and the sharing economy provide SMEs with more market access and new business models, as well as the data-driven business prospects generated through data sharing under the framework of open banking. This study provides recommendation that there is a dire need to pay attention on the complete mechanism of the SME’s in order to support them as well as promote them to show their distinction in the contribution of social and economic development. This study provides implications for the financial institutions, government agencies and society to come forward equally for the common interest.
The Role of Qi-Stagnation Constitution and Emotion Regulation in the Association Between Childhood Maltreatment and Depression in Chinese College Students
Authors: Huang Huiyuan , Song Quanwu , Chen Jiawen , Zeng Ying , Wang Wenqi , Jiao Bingqing , Lin Jiabao , Li Yan , Zhang Rong , Ma Lijun , Pan Huafeng , Shi Yafei
Published: May 2022

Background

Childhood maltreatment is known as a significant risk factor for later depression. However, there remains a lack of understanding about the mechanisms through which childhood maltreatment confers risk for depression. This study explores how Qi-stagnation constitution (QSC) and emotion regulation affect the link between childhood maltreatment and depressive symptoms in Chinese college students.

Methods

We recruited 2,108 college students aged 18–25 years between November 2020 and December 2021. Participants were required to complete four self-report questionnaires, including the Childhood Trauma Questionnaire-Short Form (CTQ-SF), Qi-Stagnation Constitution (QSC) subscale of the simplified Chinese Medicine Constitution Questionnaire, Difficulties in Emotion Regulation Scale (DERS), and the Beck Depression Inventory-II (BDI-II). Moderated mediation analyses were conducted.

Results

There was a positive correlation between childhood maltreatment and QSC, while the QSC partially mediated the effect of childhood maltreatment on depressive scores in college students. In addition, emotion dysregulation moderated the association between QSC and depressive scores.

Conclusion

These results enhance understanding of key factors influencing the link between childhood maltreatment and depressive symptoms among college students by combining the theory of TCM constitution with psychological processes. The development of strategies to prevent biased Qi-stagnation constitution and emotion dysregulation may help to improve college students’ mental health and strengthen the resilience of individuals to depression.
Factors Affecting Length of Inpatient Forensic Stay: Retrospective Study From Czechia
Authors: Páv Marek , Vňuková Martina , Sebalo Ivan
Published: May 2022

Objectives

The length of forensic stay (LoS) is a subject to country-specific legal and service systems. Therefore, the identification of common factors targetable by treatment is at the forefront of forensic psychiatric research. In this study, we present the first reports of forensic characteristics of patients from the Czechia.

Methods

We conducted a retrospective analysis of data from 260 inpatients discharged from the Bohnice Hospital (Prague) and obtained a set of sociodemographic and clinical variables as well as the Health of the Nation Outcome Scale (HoNOS) and HoNOS-secure scores.

Results

The following variables were identified as significantly associated with a longer LoS: older age, length of previous psychiatric hospitalization, olanzapine equivalent, clozapine treatment, psychosocial dysfunction, psychotic or paraphilic disorder diagnosis, and sexual offense. A shorter LoS was associated with being in a relationship, being employed before hospitalization, receiving personal support, and committing an index offense under the influence of substance. While the HoNOS score and HoNOS symptom subscale predicted a longer LoS, the HoNOS-secure subscale predicted a shorter stay.

Conclusion

In the European context, our hospital has a relatively low LoS. The results are consistent with findings linking psychotic disorders and paraphilia with a longer LoS in forensic treatment. Higher doses of antipsychotic medication or clozapine prescriptions were associated with a longer LoS. The results show a high level of unmet needs in this population, highlighting the importance of the availability of follow-up service.
Recent Chronology of COVID-19 Pandemic
Authors: Siddiqui Sazada , Alhamdi Heba Waheeb Saeed , Alghamdi Huda Ahmed
Published: May 2022

COVID-19 is highly contagious and is caused by severe acute respiratory syndrome coronavirus 2. It spreads by means of respiratory droplets and close contact with infected persons. With the progression of disease, numerous complications develop, particularly among persons with chronic illnesses. Pathological investigations indicate that it affects multiple organs and can induce acute respiratory distress syndrome. Prevention is vital and self-isolation is the best means of containing this virus. Good community health practices like maintaining sufficient distance from other people, wearing protective face masks and regular hand washing should be adopted. Convalescent plasma transfusion and the administration of the antiviral Remdesivir have been found to be effective. Vaccines offer lifesaving protecting against COVID-19 which has killed millions and our best bet for staying safe. Screening, suppression/containment as well as mitigation are the strategies implemented for controlling COVID-19 pandemic. Vaccination is essential to end the COVID-19 pandemic and everyone should have an access to them. The current COVID-19 pandemic brought the global economy to a standstill and has exacted an enormous human and financial toll.
Indoor Environmental Quality of Residential Elderly Care Facilities in Northeast China
Authors: Mu Jingyi , Kang Jian
Published: May 2022

The indoor environmental quality is based on the indoor environmental performance of buildings, such as air temperature, lighting, and acoustics. These parameters have a specific impact on users' health and experience. This study explores the relationship between the indoor environment of residential elderly care facilities in cold regions and the sensitivity of the elderly to these facilities with the aim of improving the elderly care environment. This study measured the acoustic, lighting, and thermal environment in four residential elderly care facilities in Northeast China in spring, summer, autumn, and winter through a participant survey. In the residential elderly care facilities surveyed in this study, brightness and illuminance show a nonlinear relationship with lighting evaluation. With an increase in brightness and illuminance, the satisfaction of the lighting environment in different seasons first increases and then decreases. The relative humidity of the different types of rooms varies greatly in spring and less in winter. The average air quality score of the bedroom is higher than that of the activity room. The correlation between odor assessment and overall indoor environmental quality is very poor. The results of the questionnaire survey indicate that the participants were satisfied with the facilities' overall indoor environmental quality. This quality is affected by physical, environmental, and demographic factors. This study provides a reference for the design of other residential elderly care facilities.
A Visualized Dynamic Prediction Model for Lymphatic Metastasis in Ewing's Sarcoma for Smart Medical Services
Authors: Li Wenle , Xu Chan , Hu Zhaohui , Dong Shengtao , Wang Haosheng , Liu Qiang , Tang Zhi-Ri , Li Wanying , Wang Bing , Lei Zhi , Yin Chengliang
Published: May 2022

Background

This study aims to predict the lymphatic metastasis in Ewing's sarcoma (ES) patients by nomogram. The risk of lymphatic metastasis in patients with ES was predicted by the built model, which provided guidance for the clinical diagnosis and treatment planning.

Methods

A total of 929 patients diagnosed with ES were enrolled from the year of 2010 to 2016 in the Surveillance, Epidemiology, and End Results (SEER) database. The nomogram was established to determine predictive factors of lymphatic metastasis according to univariate and multivariate logistic regression analysis. The validation of the model performed using multicenter data (n = 51). Receiver operating characteristics (ROC) curves and calibration plots were used to evaluate the prediction accuracy of the nomogram. Decision curve analysis (DCA) was implemented to illustrate the practicability of the nomogram clinical application. Based on the nomogram, we established a web calculator to visualize the risk of lymphatic metastases. We further plotted Kaplan-Meier overall survival (OS) curves to compare the survival time of patients with and without lymphatic metastasis.

Results

In this study, the nomogram was established based on six significant factors (survival time, race, T stage, M stage, surgery, and lung metastasis), which were identified for lymphatic metastasis in ES patients. The model showed significant diagnostic accuracy with the value of the area under the curve (AUC) was 0.743 (95%CI: 0.714–0.771) for SEER internal validation and 0.763 (95%CI: 0.623–0.871) for multicenter data external validation. The calibration plot and DCA indicated that the model had vital clinical application value.

Conclusion

In this study, we constructed and developed a nomogram with risk factors to predict lymphatic metastasis in ES patients and validated accuracy of itself. We found T stage (Tx OR = 2.540, 95%CI = 1.433–4.503, P < 0.01), M stage (M1, OR = 2.061, 95%CI = 1.189–3.573, P < 0.05) and survival time (OR = 0.982, 95%CI = 0.972–0.992, P < 0.001) were important independent factors for lymphatic metastasis in ES patients. Furthermore, survival time in patients with lymphatic metastasis or unclear situation (P < 0.0001) was significantly lower. It can help clinicians make better decisions to provide more accurate prognosis and treatment for ES patients.
COVID-19 Mobile Health Apps: An Overview of Mobile Applications in Indonesia
Authors: Sujarwoto Sujarwoto , Augia Trisfa , Dahlan Hendery , Sahputri Rindi Ardika Melsalasa , Holipah Holipah , Maharani Asri
Published: May 2022

Background

Mobile health applications (mHealth apps) have been widely used for various purposes for mitigating the COVID-19 pandemic, such as self-assessment, contact tracing, disseminating information, minimizing exposure, and reducing face-to-face health consultation. The objective of this study is to systematically review COVID-19 related mHealth apps and highlight gaps to inform the development of future mHealth initiatives in Indonesia.

Methods

A systematic search strategy using a PRISMA flowchart was used to identify mHealth apps available in Google Play and Apple Play stores. We searched mHealth apps using certain specific terms related to COVID-19 outbreaks. The inclusion criteria were apps-based smartphone users related to COVID-19 using local language, free of cost, available in the Google Play and Apple Play Stores, and supported by the Indonesian government. We excluded games, apps on infectious diseases unrelated to COVID-19 specifically, and apps with non-Bahasa Indonesia (Indonesian language). The selected mHealth apps were assessed based on two measures: (1) the WHO guidelines on digital health intervention and (2) the four dimensions of the mHealth technology fit framework. In addition, user feedback from experienced and non-experienced users was conducted to evaluate four dimensions of the apps.

Results

A total of 339 mHealth apps were generated from the initial search, remaining seven selected apps that met inclusion criteria. The results highlighted that mHealth apps reviewed had still not been widely used by the general public. The applications were purposed to disseminate information, conduct a self-risk assessment, provide an online community forum, and telemedicine or teleconsultation regarding COVID-19. Data services, including data storage, aggregation, and data exchange, are available in most apps. The rarest function found was contact tracing and assisting health management and health workers, such as the availability of testing facilities, reporting test results, and prescribing medication. The main issues reported were the lack of data security and data privacy protection, integration and infrastructures, usability, and usefulness.

Conclusion

Our study highlighted the necessity to improve mHealth apps' functions related to assisting health workers and the function of digital contact tracing. An effort to increase public awareness regarding the use of mHealth is also necessary to streamline the function of this innovation. Policymakers must consider usefulness, usability, integration, and infrastructure issues to improve their mHealth function.
Associations Between Online Learning, Smartphone Addiction Problems, and Psychological Symptoms in Chinese College Students After the COVID-19 Pandemic
Authors: Zhang Chi , Hao Jinjuan , Liu Ye , Cui Ju , Yu Hao
Published: May 2022

Background

Smartphone-based online education gained popularity during and after the COVID-19 pandemic. Although recent studies have highlighted the association between problematic smartphone use (PSU) and mental health symptoms, the potential role of online learning in this relationship remains unclear. This study aimedto analyze the relationships between higher education modes, PSU, and related psychological symptoms in university students.

Methods

A total of 1,629 Chinese university students from five provinces completed a web-based questionnaire survey between March 2020 and October 2021. Demographic characteristics and learning conditions were recorded. All participants completed the Smartphone Addiction Scale-Short Version, Patient Health Questionnaire, Generalized Anxiety Disorder Scale, and Athens Insomnia Scale. Multiple regressions models and stratified analyses were used to examine the association between online education mode, PSU, and symptoms of depression, anxiety, and insomnia.

Results

The prevalence of PSU was 58.5%. Students who relied primarily on online learning had a higher prevalence of depressive symptoms (29.95% vs. 22.24%), anxiety symptoms (25.13% vs. 18.91%), and insomnia symptoms (75.89% vs. 70.27%) than those who relied on traditional face-to-face learning (Ps< 0.05). After adjusting for covariates, subjects with PSU were more likely to report depressive symptoms (AdjOR = 3.14, 95% CI = 2.26–4.37), anxiety symptoms (AdjOR = 3.73, 95% CI = 2.13–4.59), and insomnia symptoms (AdjOR = 2.96, 95% CI = 2.23–3.92) than those without PSU. Furthermore, the associations of PSU with depressive symptoms (OR = 4.66 vs. 2.33,Pfor interaction = 0.015) and anxiety symptoms (OR = 6.05 vs. 2.94,Pfor interaction = 0.021) were more pronounced in the online learning group.

Conclusion

Our study provides preliminary evidence that Chinese university students have serious smartphone addiction problems, which are associated with depressive, anxiety, and insomnia symptoms. Online learning is found to exacerbate PSU and mental health problems. Our findings provide valuable information for targeted psychological interventions in the post-COVID-19 era.
Extreme Heat and COVID-19: A Dual Burden for Farmworkers
Authors: López-Carr David , Vanos Jennifer , Sánchez-Vargas Armando , Vargas Río , Castillo Federico
Published: May 2022

Currently, there is an extensive literature examining heat impacts on labor productivity and health, as well as a recent surge in research around COVID-19. However, to our knowledge, no research to date examines the dual burden of COVID-19 and extreme heat on labor productivity and laborers' health and livelihoods. To close this research gap and shed light on a critical health and livelihood issue affecting a vulnerable population, we urge researchers to study the two topics in tandem. Because farmworkers have a high incidence of COVID-19 infections and a low rate of inoculation, they will be among those who suffer most from this dual burden. In this article, we discuss impacts from extreme heat and COVID-19 on farm laborers. We provide examples from the literature and a conceptual framework showing the bi-directional nature of heat impacts on COVID-19 and vice versa. We conclude with questions for further research and with specific policy recommendations to alleviate this dual burden. If implemented, these policies would enhance the wellbeing of farmworkers through improved unemployment benefits, updated regulations, and consistent implementation of outdoor labor regulations. Additionally, policies for farmworker-related health needs and cultural aspects of policy implementation and farmworker outreach are needed. These and related policies could potentially reduce the dual burden of COVID-19 and extreme heat impacts while future research explores their relative cost-effectiveness.
Non-Invasive and Mechanism-Based Molecular Assessment of Endometrial Receptivity During the Window of Implantation: Current Concepts and Future Prospective Testing Directions
Authors: Sun Bei , Yeh John
Published: May 2022

Suboptimal endometrial receptivity and altered embryo-endometrial crosstalk account for approximately two-thirds of human implantation failures. Current tests of the window of implantation, such as endometrial thickness measurements and the endometrial receptivity assay, do not consistently improve clinical outcomes as measured by live birth rates. Understanding the mechanisms regulating the endometrial receptivity during the window of implantation is a critical step toward developing clinically meaningful tests. In this narrative review, the available literature is evaluated regarding mechanisms that regulate the endometrial receptivity during the window of implantation and the current tests developed. Overall, both animal and human studies point to five possible and interrelated mechanisms regulating the endometrial window of implantation: suitable synchrony between endometrial cells, adequate synchrony between the endometrium and the embryo, standard progesterone signaling and endometrial responses to progesterone, silent genetic variations, and typical morphological characteristics of the endometrial glands. The biological basis of current clinical markers or tests of window of implantation is poor. Future studies to elucidate the mechanisms shaping the window of implantation and to investigate the potential markers based on these mechanisms are required. In addition, molecular testing of the endometrium at single-cell resolution should be an initial step toward developing clinically meaningful tests for the optimal window of implantation. As understanding of the optimal window of implantation continues to evolve, one can envision the future development of non-invasive, mechanism-based testing of the window of implantation.
A Critical Review of Hyperloop (Ultra-High Speed Rail) Technology: Urban and Transport Planning, Technical, Environmental, Economic, and Human Considerations
Authors: Premsagar Smriti , Kenworthy Jeffrey
Published: May 2022

Companies globally have been trying to alter existing transportation systems to maximize public transport benefits, especially in the sector of high-speed (HS) ground transportation. The latest invention of such is Elon Musk's ultra-high-speed rail (UHSR), hyperloop. This technology enables a rail service to operate at a potential speed of 1,200 km/h. Hyperloop's ambitious speed goal has the potential to result in time-space shrinkage, which would then make distant cities more accessible with greatly reduced travel times. Since 2013, several companies have been vigorously promoting hyperloop development in various locations worldwide and competing to construct the world's first functional and commercially viable hyperloop. India, a country struggling with existing public transportation and urban mobility needs, agreed to construct a hyperloop through the company “Virgin Hyperloop One.” This paper first investigates the key technical, environmental, economic and human considerations in assessing the applicability of hyperloop to a particular location. It also considers in some detail the likely urban and regional planning and transport policy implications of the hyperloop technology based on the known effects of existing high-speed rail (HSR) systems. The paper concludes that many of the claims about hyperloop are subject to contrary information, meaning that great caution and prudence are currently needed regarding attempts at commercial deployment.
Clinicopathological Characteristics of Primary Appendiceal Mucinous Neoplasm and Recurrence After Radical Resection
Authors: Wang Zaibiao , Yin Manman , Shao Jiayun , Yin Zhipeng , Peng Jie , Lu Zhengmao
Published: May 2022

Objective

Appendiceal mucinous neoplasm (AMN) is a rare obstructive dilatation of the appendix caused by an intraluminal accumulation of mucoid material, showing an insidious onset and few specific clinical manifestations. The purpose of the study is to analyze clinicopathological characteristics of primary AMN and recurrence after radical resection.

Methods

A total of 50 patients were included in the retrospective cohort study of AMN. Patient data, such as demographics, tumor characteristics, surgical management, preoperative serum carcinoembryonic antigen (CEA), and carcinoembryonic antigen 19-9 (CA19-9) levels, were collected. All patients were followed-up with interval CT scans until the end of December 2021, with overall survival (OS) and progression-free survival (PFS) being calculated.

Results

All patients were confirmed as AMN by pathological diagnosis after surgery, including 28 cases (56.00%) of low-grade AMN (LAMN) and 22 cases (44.00%) of non-LAMN. Among 50 patients with AMN, there were 12 cases (24.00%) complicated with pseudomyxoma peritonei (PMP). Higher proportions of patients with pTis, pT3, pT4a, ruptured at presentation, and PMP were found in patients with non-LAMN patients than LAMN (p < 0.05). There was a remarkable difference about preoperative serum CA19-9 levels between patients with LAMN and non-LAMN (p = 0.044). Patients complicated with PMP had a higher proportion of patients with ruptured at presentation than those who were not (p < 0.001). The patients with PMP had increased tumor size compared with those without PMP (p = 0.031). Remarkable differences were observed in terms of preoperative serum CA19-9 (p = 0.009) levels between patients with PMP and without PMP. We performed a multivariate analysis of the presence or absence of PMP and found that ruptured at presentation was found to be a risk factor for PMP in patients with AMN (p = 0.003). The PFS in the patients with PMP and those without was 33.33% (4/12) and 2.63% (1/38), showing a significant difference (P = 0.002).

Conclusion

The study demonstrates that ruptured at presentation and PMP may influence the prognosis and survival of patients with AMN.
Fluorescence-Guided Identification of the Thoracic Duct by VATS for Treatment of Postoperative Chylothorax: A Short Case Series
Authors: Londero Francesco , Grossi William , Vecchiato Massimo , Martino Antonio , Ziccarelli Antonio , Petri Roberto , Morelli Angelo
Published: May 2022

Background

Chylothorax is a relatively rare complication after surgery of the mediastinum. The occurrence and the results of surgical treatment of this condition are difficult to foresee due to the wide heterogeneity in thoracic duct anatomy.

Case summary

We report two cases of postoperative chylothorax treated with ligation by video-assisted thoracoscopic surgery (VATS). The first patient developed a massive left chylothorax shortly after discharge, following radical excision of a seminoma-involved left para-aortic lymphadenopathy. The second patient developed a high-output right chylothorax following VATS upper bilobectomy. In both cases, a surgical revision by VATS was performed. Inguinal injection of indocyanine green allowed an easy visualization of the lymphatic leakage point. In both cases, oral feeding was rapidly restarted after surgery. No recurrence of chylothorax was observed.

Conclusion

The use of indocyanine green may greatly improve the identification of the thoracic duct during surgical ligation by VATS, with a favorable impact on the postoperative course and overall admission costs.
Expanding Aesthetics
Authors: French Fiona
Published: May 2022

This paper seeks to expand traditional aesthetic dimensions of design beyond the limits of human capability in order to encompass other species' sensory modalities. To accomplish this, the idea of inclusivity is extended beyond human cultural and personal identities and needs, to embrace multi-species experiences of places, events and interactions in the world. This involves drawing together academic perspectives from ecology, neuroscience, anthropology, philosophy and interaction design, as well as exploring artistic perspectives and demonstrating how these different frames of reference can inspire and complement each other. This begins with a rationale for the existence of non-human aesthetics, followed by an overview of existing research into non-human aesthetic dimensions. Novel aesthetic categories are proposed and the challenge of how to include non-human aesthetic sensibility in design is discussed.
The Influence of Different Amaranth Leaf Meal Inclusion Levels on Performance, Blood Profiles, and Gut Organ Characteristics of Ross 308 Broiler Chickens
Authors: Manyelo Tlou Grace , Sebola Nthabiseng Amenda , Ng'ambi Jones Wilfred , Weeks William , Mabelebele Monnye
Published: May 2022

This study aimed to determine the effect of varying inclusion levels of amaranth leaf meal on the performance, blood profiles, and gut organ characteristics of Ross 308 broiler chickens. A total of 200, day-old, Ross 308 broiler chicks were randomly allocated to five dietary treatments in a complete randomized design, with each group having four replicates with ten chicks. Amaranth leaf meal (ALM) inclusion levels used in this study were 0, 5, 10, 15, and 20%. Body weight and feed intake were measured weekly to calculate the feed conversion ratio. Gut organ weights, lengths, organ pH, and blood profiles were measured and the general linear model of statistical analysis software was used to analyze collected data. ALM had no effect (p > 0.05) on feed intake, body weight, or the feed conversion ratio of Ross 308 broiler chickens between 1–21 and 22–42 days, respectively. Furthermore, ALM inclusion levels had no effect (p > 0.05) on dry matter (DM) or gross energy (GE) digestibility of Ross 308 broiler chickens. Ross 308 broiler chickens, which were fed with 5% ALM inclusion levels, had higher (p < 0.05) white blood cells, lymphocytes, and eosinophils than those fed with diets containing 0, 10, 15, and 20%. Chickens that were fed with 0 and 20% ALM inclusion levels had higher (p < 0.05) heterophils than those fed with diets containing 5, 10, and 15%. Chickens that were fed with 15% ALM inclusion levels had higher (p < 0.05) monocytes, eosinophils, and basophils than those fed with diets containing 0, 10, and 20%. Apart from Ile, ALM inclusion of 5 and 10% had higher (p < 0.05) essential and nonessential amino acid digestibility in Ross 308 broiler chickens. ALM inclusion levels had no effect (p > 0.05) on gut organ lengths or weights of Ross 308 broiler chickens aged 21 and 42 days. In conclusion, 5, 10, and 15% ALM inclusion levels can be included in broiler chicken diets as they showed favor in most of the affected parameters.
Analysis of the Economic, Labour, and Management Effects of COVID-19 on Rural Accommodation: An Application to a Rural European Province (Cáceres, Spain)
Authors: Sánchez-Rivero Marcelino , Rodríguez-Rangel Mª Cristina , Cerro Paloma García , García Ana Mª Manjón
Published: May 2022

The COVID-19 pandemic has changed the consumption habits of tourists to benefit sustainable destinations that are not overcrowded, such as rural tourism destinations. However, the periods of compulsory lockdown have had devastating effects on tourism businesses operating in rural areas and have even jeopardised their economic viability. The aim of this article is to quantify in relative terms the effects that the period of compulsory lockdown in a markedly tourist country, such as Spain, between March and May 2020 has had on rural accommodation in one of the most rural provinces of Spain (Cáceres). Based on a random sample of 225 rural accommodation establishments and the consideration of various factors, statistical techniques of comparison of means and proportions were used to detect differences in the intensity of the effects of the compulsory lockdown on the economic-financial management, bookings, facilities, and input of rural accommodation establishments in the province. The results obtained show that the economic, labour, and management effects of the COVID-19 pandemic on rural tourism businesses in the province of Cáceres have been very substantial. In particular, the businesses with the highest level of tourist services on supply, i.e., those that, in addition to accommodation, also offer other tourist activities, have been the most affected. In view of this situation, urgent emergency measures have been put in place at a provincial level to alleviate the economic loss and the destruction of jobs caused by this pandemic.
Novel Quantitative PCR for Rhodococcus equi and Macrolide Resistance Detection in Equine Respiratory Samples
Authors: Narváez Sonsiray Álvarez , Fernández Ingrid , Patel Nikita V. , Sánchez Susan
Published: May 2022

R. equi is an important veterinary pathogen that takes the lives of many foals every year. With the emergence and spread of MDR R. equi to current antimicrobial treatment, new tools that can provide a fast and accurate diagnosis of the disease and antimicrobial resistance profile are needed. Here, we have developed and analytically validated a multiplex qPCR for the simultaneous detection of R. equi and related macrolide resistance genes in equine respiratory samples. The three sets of oligos designed in this study to identify R. equi housekeeping gene choE and macrolide resistance genes erm(46) and erm(51) showed high analytic sensitivity with a limit of detection (LOD) individually and in combination below 12 complete genome copies per PCR reaction, and an amplification efficiency between 90% and 147%. Additionally, our multiplex qPCR shows high specificity in in-silico analysis. Furthermore, it did not present any cross-reaction with normal flora from the equine respiratory tract, nor commonly encountered respiratory pathogens in horses or other genetically close organisms. Our new quantitative PCR is a trustable tool that will improve the speed of R. equi infection diagnosis, as well as helping in treatment selection.
Evaluation of Renal Blood Flow in Dogs during Short-Term Human-Dose Epoprostenol Administration Using Pulsed Doppler and Contrast-Enhanced Ultrasonography
Authors: Hanazono Kiwamu , Itami Takaharu , Hayasaka Ikuto , Miyoshi Kenjiro , Hori Ai , Kato Keiko , Endoh Daiji
Published: May 2022

Prostacyclin is an in vivo bioactive substance that regulates renal blood flow (RBF). Information regarding how epoprostenol, a prostacyclin preparation, affects RBF in dogs is lacking. We investigated the effects of short-term epoprostenol administration on RBF in six healthy dogs under anesthesia by administering it intravenously at human doses—2, 5, and 10 ng/kg/min for 20 min. RBF was evaluated before and during epoprostenol administration using pulsed Doppler ultrasonography, and renal perfusion was evaluated using contrast-enhanced ultrasonography. Effects on renal and systemic circulation were evaluated by measuring systolic arterial, mean arterial, diastolic arterial, pulmonary arterial, mean right atrial, and pulmonary capillary wedge pressures; heart rate; and cardiac output. Kruskal–Wallis and Bonferroni multiple comparison tests and Spearman’s rank correlation coefficient were used for statistical analyses. As epoprostenol dosage increased, the peak systolic and end diastolic velocity of the renal artery, maximum and minimum venous flow velocities of the interlobular and renal veins, and heart rate all tended to increase, although not significantly. Our results indicate that human-dose epoprostenol administration in dogs does not cause significant changes in renal or systemic circulation. However, the human doses used may have been too low to produce a clinical effect in dogs.
Assessing Genetic Variation in Wild and Domesticated Pikeperch Populations: Implications for Conservation and Fish Farming
Authors: Tsaparis Dimitrios , Lecocq Thomas , Kyriakis Dimitrios , Oikonomaki Katerina , Fontaine Pascal , Tsigenopoulos Costas S.
Published: May 2022

The pikeperch is a freshwater/brackish water fish species with growing interest for European aquaculture. Wild populations show signs of decline in many areas of the species natural range due to human activities. The comparative evaluation of genetic status in wild and domesticated populations is extremely useful for the future establishment of genetic breeding programs. The main objective of the present study was to assess and compare the genetic variability of 13 domesticated populations from commercial farms and 8 wild populations, developing an efficient microsatellite multiplex tool for genotyping. Partial cytochrome b gene sequences were also used to infer phylogeographic relationships. Results show that on average, the domesticated populations do not exhibit significantly lower levels of genetic diversity compared to the wild ones and do not suffer from inbreeding. Nuclear data provide evidence that pikeperch populations in Europe belong to at least two genetically differentiated groups: the first one is predominantly present in Northern Europe and around the Baltic Sea, while the second one comprises populations from Central Europe. In this second group, Hungarian origin populations constitute a differentiated stock that needs special consideration. Aquaculture broodstocks analyzed appear to contain fish of a single origin with only a few exceptions.
Ellagic Acid Improves Antioxidant Capacity and Intestinal Barrier Function of Heat-Stressed Broilers via Regulating Gut Microbiota
Authors: Yang Tai , Liu Bifan , Wang Yujie , Huang Xiangying , Yan Zhaoming , Jiang Qian , Chen Qinghua
Published: May 2022

Heat stress (HS) has been revealed to damage the antioxidant system and intestinal barrier function, which greatly threatens poultry production. The present study investigated the effects of dietary ellagic acid (EA) on the antioxidant system, gut barrier function, and gut microbiota of heat-stressed broilers. Arbor Acres 14-day-old broilers numbering 360 were randomly divided into six groups, including one negative control group (NC) and five experimental groups. The broilers in the NC group were supplemented with a basal diet at a normal temperature (23 ± 2 °C). The broilers in the experimental groups were supplemented with basal diets containing EA at different doses (0, 75, 150, 300, and 600 mg/kg) at HS temperature (35 ± 2 °C). The experiment lasted for 4 weeks. Results showed that dietary EA reduced the corticosterone (CORT), LPS, and diamine oxidase (DAO) levels in the serum of heat-stressed broilers. Additionally, dietary EA improved the antioxidant enzyme activity and mRNA levels of Nrf2/HO-1 in the ileum of heat-stressed broilers. The relative abundances of Streptococcus, Ruminococcus_torques, Rothia, Neisseria, Actinomyces, and Lautropia in the cecum were significantly reduced by the EA supplementation in a dose-dependent manner. Notably, the LPS, DAO, and MDA in the serum were revealed to be positively correlated with the relative abundances of Rothia, Neisseria, Actinomyces, and Lautropia, while the GSH-px, SOD, and CAT levels in the serum were negatively correlated with the relative abundances of Ruminococcus_torques, Rothia, Neisseria, Actinomyces, Streptococcus, and Lautropia. Taken together, dietary EA improved the antioxidant capacity, intestinal barrier function, and alleviated heat-stressed injuries probably via regulating gut microbiota.