bluuebunny/crossref_metadata_2025 huggingface dataset:
Strengthening the Performance of Micro, Small, and Medium Enterprises (MSMEs) Through Social Media Adoption with Human Resource Competency as Moderation and Implementation of The Penta Helix Model in Facing New Normal Challenges in Jember Regency
Authors: Mawardi Ahmad Ahsin Kusuma , Farida Lilik , Nusbantoro Ariwan Joko , Utami Elok Sri , Endhiarto Tatok , Apriliana Tria
Published: April 2024

The Covid-19 pandemic has had a negative impact on MSMEs, and has encouraged MSMEs to be more creative in trying to maintain and develop their business during the pandemic, especially through the adoption of social media for marketing activities. However, the competence of HR in MSMEs is still an obstacle to the process of adopting social media. The aims of this study were (1) to analyze the role of HR competence in moderating social media adoption on MSME performance, and (2) to analyze the implementation of the pentahelix model in strengthening MSME performance through the role of social media adoption and HR competence in facing the new normal challenges in Jember Regency. The research method used is mixed method research, which combines both quantitative and qualitative research approaches. The sample of this research is 100 SMEs. Quantitative data analysis was carried out using the PLS SEM technique. Qualitative data analysis was carried out with FGDs with stakeholders such as the government represented by the Jember District Office of Cooperatives and MSMEs, the media, the MSME community, academics, and business people. The results of the verification analysis using the SEM analysis technique show that technology has a significant effect on the performance of MSMEs in Jember Regency. Meanwhile, organizational, and environmental variables did not have a significant effect on the performance of MSMEs in Jember Regency. HR competence has a significant effect on the performance of MSMEs in Jember Regency. HR competence does not moderate the effect of technology on the performance of MSMEs in Jember Regency. HR competence does not moderate organizational influence on MSME performance in Jember Regency. HR competence does not moderate the influence of the environment on the performance of MSMEs in Jember Regency. To strengthen the performance of MSMEs through the adoption of social media, all stakeholders have an important role, where the government becomes a facilitator in conducting training and mentoring. With the involvement of academics to conduct research so that market segmentation is more appropriate for marketing through social media. Then businesspeople who have been involved in digital marketing play a role in transferring knowledge, and the role of the media is to strengthen marketing carried out by MSMEs through social media.
Komunikasi, Lingkungan Kerja, Disiplin dan Kinerja pada Karyawan PT. Pangan Lestari (Finna Food) Sidoarjo
Authors: Musrifa Nova , Firdaus Vera , Ubaidillah Hasan
Published: April 2024

This study aims to determine the effect of communication, work environment, and work discipline on employee performance. This research uses quantitative methods with a descriptive approach. The main research data used a questionnaire, which was analyzed by multiple linear regression, and processed with PLS (Partial Least Square). The research population was employees of PT Pangan Lestari Sidoarjo with a total of 171 respondents. The sampling technique used proportional random sampling. The results of this study indicate that communication affects employee performance improvement. The work environment has an influence on employee performance, and employee discipline can improve employee performance.
Pengaruh Teknologi Finansial dan Inklusi Keuangan Terhadap Ketimpangan Pendapatan di Negara ASEAN-6
Authors: Pratama Yonanda Yudha , Titik Crisanty Sutristyaningtyas
Published: April 2024

This study aims to analyze the long-term and short-term effects of financial technology and financial inclusion on income inequality in ASEAN-6 countries, namely Indonesia, Malaysia, Singapore, Thailand, Philippines and Vietnam, for the period between 2011 and 2022. Indicators used in This research is income inequality using the Gini coefficient, financial inclusion using financial inclusion indicators based on the Sarma model and data on e-money usage as an indicator of financial technology. The data analysis technique used is Panel Auto Regressive Distributed Lag (ARDL). The results of this study found that in the long term the financial technology variable has a significant negative effect, while in the short term it has no significant effect on income inequality in ASEAN-6, and the financial inclusion variable in the long term has a significant positive effect, whereas in the short term it has no significant effect on income inequality in ASEAN-6.
Obàtálá : criador de criaturas e criadores
Authors: Oribato Obàtálá Ilé-Ifẹ̀ Oba Oribato Obàtálá Ilé-Ifẹ̀ , Oladotun Okanlawon Dada Olaolu Oladotun Okanlawon Dada , Oribato Obàtálá Ilé-Ifẹ̀ Yeye Oribato Obàtálá Ilé-Ifẹ̀ , Dias Susana Oliveira
Published: April 2024

É com alegria que a Coleção Jurema tem a honra de publicar o livro Obàtálá: criador de criaturas e criadores, de Oba Oribato Obàtálá Ilé-Ifẹ̀ ẹ̀, Olaolu Oladotun Okanlawon Dada Ooo Dada, Yeye Oribato Obàtálá Ilé-Ifẹ̀ ẹ̀ e Susana Oliveira Dias. A obra, rica em narrativas, desenhos e fotografias, nos permite uma relação respeitosa e sensível com a filosofia Youruba ao contar como o orixá Obàtálá - conhecido como o rei dos orixás e o deus da criatividade para o povo Yoruba- criou o mundo e os seres humanos junto com Èșù, além de nos apresentar as relações entre Obàtálá e sua esposa Yemòó, e, ainda, o primeiro templo desse orixá na cidade de Ilé Ifẹ̀ ẹ̀, na Nigéria. É ali que também temos a oportunidade de conhecer o processo de coroação de um rei no templo de Obàtálá. Ao publicar este livro-objeto de arte, a Diretoria de Cultura reafirma-se como espaço institucional de valorização de diferentes modos de pensamento e de conhecimento
Incidence of Thyroid Cancer in Bethesda III Thyroid Nodules: A Retrospective Analysis at a Single Endocrine Surgery Center
Authors: Hassan Iyad , Hassan Lina , Balalaa Nahed , Askar Mohammad , Alshehhi Hussa , Almarzooqi Mohamed
Published: April 2024

Background: Fine-needle aspiration cytology (FNAC) is widely used to diagnose and monitor thyroid nodules. The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) is the standard for interpreting FNAC specimens. The risk of malignancy in Bethesda III nodules also known as Atypia of Undetermined Significance (AUS) varies significantly throughout several studies published worldwide. This retrospective study examines the risk of cancer in thyroid FNAC categorized as Bethesda III, as identified in the final histopathology of thyroidectomy specimens at a single endocrine surgery center. Methods: This retrospective cohort analysis included 1038 consecutive patients who underwent elective thyroid surgery with complete follow up data between January 2020 and March 2024. Preoperative data on clinical and pathological characteristics have been collected. The final histopathology report from the thyroidectomy specimen was compared to the results of the preoperative FNAC on nodules that were judged to be Bethesda category III. Statistical methods were performed using SPSS version 29. Results: A total of 670 ultrasound-guided FNACs (64.5%) performed during the study period were included in the final analysis. The study population was predominantly female, represented by 79.6% of patients with a mean age of 42.5 (SD 12.1), while 20.4% were male and significantly older with mean age 45.13 years (p = 0.02). The FNAC inadequacy rate was 5.1%, which was associated with a high risk of malignancy (6 out of 34, 17.6%). Out of the total sample size of 170 patients classified as group III, 57 were found to have malignancies in final surgical histopathology, representing 33.5% of the cases within this category. The secondary gender-related outcome analysis showed that female patients classified under the Bethesda II category had a significantly higher risk of malignancy, with a rate of 21.2%, compared to males who had a malignancy rate of 3.4% in the same Bethesda category (p = 0.001, chi square test). However, female had more better prognostic non-invasive tumors than male (p = 0.02, chi square test). Conclusion: The study's results indicate that Bethesda categories II and III are associated with a higher risk of malignancy in comparison to the reports of the first and third editions of the TBSRTC, particularly for female patients classified under category II.
Sub-Saharan Irregular Migrant Women’s Sexuality: A Qualita-Tive Study in Humanitarian Reception Centers Title
Authors: García-León Alicia , Granero-Molina José , Jiménez-Lasserrotte María del Mar
Published: April 2024

Irregular female migration to Europe is a growing phenomenon, as more and more women are fleeing their countries of origin due to gender inequality and violence. During the migration process, women experience physical, psychological and social problems that affect their sex lives. The aim of our study is to describe and understand how irregular migrant wom-en living in humanitarian reception centers experience their sexuality at different stages of the migration process. This qualitative phenomenological study collected data through a sixteen in-depth interviews with irregular migrant women between January and February 2023. Data anal-ysis was carried out using ATLAS-ti 23.0 software, from which three themes were extracted: 1) The sexual reality of sub-Saharan women, 2) In search of a better life: take the risk or surrender, and 3) The migrant sexual revolution. The sexual reality of sub-Saharan women is subject to a complex normative order. The migratory process has severe consequences on migrant women's sex life. The sexual needs of irregular migrant women admitted to humanitarian reception cen-ters undergo a process of change that must be understood by healthcare providers in order to make improvements to care provision.
In Vitro Evaluation of Surface Roughness and Color Variation after Two Brushing Protocols with Toothpastes Containing Different Whitening Technologies
Authors: Lobito Angel , Colaço Catarina , Costa Joana , Caldeira Jorge , Proença Luís , Mendes José João
Published: April 2024

The aim was to evaluate the effect of different whitening toothpastes on the enamel surface roughness and color variation. Twenty-four molars were sectioned and divided into eight groups (n = 3), considering the two factors under study: toothpaste type (Colgate® Total Original, Oral B® 3D White Luxe Perfection, Curaprox® Black is White, and Signal® White Now) and brushing protocol (short-term and a long-term). Surface roughness was examined by atomic force microscopy (AFM), and color change (ΔE) was measured using the CIE L*a*b* system. Data were statistically analyzed using comparative parametric tests at a 5% significance level. In the short-term protocol, only the Signal® White Now toothpaste increased surface roughness (p = 0.038) compared to the Colgate® Total Original group. No significant differences (p > 0.05) were observed in surface roughness in the long-term protocol. Regarding color variation, no statistically significant differences (p > 0.05) were observed in either protocol. Overall, the whitening toothpastes did not affect enamel surface roughness or color, except for Signal® White Now causing increased roughness in the short-term protocol. However, all toothpastes induced a visual change in color.
Disentangling the Physiological Responses of Sweet Orange Citrus Trees to Optimize the Design of Deficit Irrigation Strategies
Authors: Rubio-Casal Alfredo Emilio , Durán-Zuazo Victor Hugo , García-Tejero Iván Francisco
Published: April 2024

The aim of this work was to describe the physiological limitations induced under drought conditions in young sweet orange trees, including the crop capability to recuperate its physiological status once re-watering, and after a water withholding. The trial was conducted during two consecutive months (July and August) in two-years old sweet orange trees. Three irrigation treatments were arranged: A full irrigation treatment; (FI); a low-frequency deficit-irrigation treatment (LFDI); and a sustained-deficit irrigation (SDI) treatment. The obtained results showed that for Stem values below -1.5 MPa, significant decreases in gas exchange rates, evidencing diffusive limitations to drought stress. Additionally, there was evidence of increased osmolyte synthesis, compatible as a defensive response to prevent oxidative damage. Likewise, the isohydric behaviour observed also resulted in significant decreases in gs even for moderate stress situations. In addition, it was observed that in the LFDI treatment, the stress levels reached caused a significant increase in the levels of Pro and MDA, which were not equal to those detected in FI during the recovery periods, which leads us to assume that potential values below -1.8 MPa would be causing significant oxidative damage with no capacity for subsequent recovery, and probably affecting the final yield.
Predictive Modelling and Optimization of the Mechanical Properties of Laser-Coated NB/SiC/Ni Welds Using an ANFIS
Authors: Zou Zhe , Chen Juan , Jean Ming-Der
Published: April 2024

In the present work, a predictive modelling and optimization with the adaptive network based fuzzy inference system(ANFIS) modelling of mechanical properties of laser-coated NB/SiC/Ni welds was studied based on Taguchi design by laser cladding. An ANFIS model based on a Sugeno type fuzzy inference system was developed for predicting the hardness properties of SiC/BN/Ni welds by laser cladding with experimental data required for network training and prediction. Based on analysis of variance, three important factors were taken as inputs for the fuzzy logic inferences, while the hardness properties was taken as the output of the ANFIS. The microstructure of welds were analysed using scanning electron microscopy with an energy dispersive X-Ray spectrometer. Highly developed leaf-like dendrites and eutectic crystals were found in some areas of the melting zone for the BN/SiC/Ni weld, which was significantly hardened. The ANFIS model based on Taguchi's design provides a better pattern of response because the predicted and experimental values were highly similar. As a result, a satisfactory result was achieved between the predicted and experimental values of hardness in laser-coated NB/SiC/Ni welds, whereby the success and validity of the method was verified.
The Impact and Mechanism Analysis of Diatomite on the Sag Resistance of Geopolymer Coatings
Authors: Hu Yuan , Jin Zuquan , Pang Bo , Du Zhantao , Li Xiangxiang , Huang Yuxin
Published: April 2024

The reduction in rheological parameters and dissolution rate of precursors in geopolymer coatings during early hydration significantly contributes to sagging. This study aims to improve the sag resistance of these coatings by incorporating diatomite filler. Rheological testing was conducted to assess the impact of diatomite and its concentration on yield stress, plastic viscosity, and thixotropy of the geopolymer coatings. The results indicated that diatomite's large specific surface area and high reactivity have a significant influence on the rheological parameters and early dissolution rate of precursors. With a diatomite concentration of 1.1%, the coating exhibited a yield stress of 2.749 Pa and a plastic viscosity of 0.921 Pa·s, maintaining stability, homogeneity, and no sagging at a thickness of 600 μm. Furthermore, the highly active SiO2 in diatomite participates in the secondary hydration reaction of the geopolymer materials, leading to the formation of substantial C-(A)-S-H gel. This gel enhances internal interconnectivity within the coating, thereby improving its rheological and mechanical properties.
An Overlooked Group of Citizen Scientists in NIS Information: Shell Collectors and Their Contribution to Molluscan NIS Diversity
Authors: Zenetos Argyro , DELONGUEVILLE Cristiane , SCAILLET Roland
Published: April 2024

This work reports 60 marine alien molluscs, collected by two Belgian citizen scientists, from nine countries across the Mediterranean Sea and the Sea of Marmara. Some of their published observations concerning the collecting dates are compared with the year of first publication for these alien molluscs reported in the literature, which enabled to backdate some of these introductions. This underlines the importance of collaboration between volunteers and institutional scientists in tracing variations and changes in the environment and biodiversity.
Characterization and Anti-Biofilm Activity of Lytic Enterococcus Phage vB_Efs8_KEN04 against Clinical Isolates of Multidrug-Resistant Enterococcus faecalis in Kenya
Authors: Soro Oumarou , Kigen Collins , Nyerere Andrew , Musila Lillian
Published: April 2024

Enterococcus faecalis is a growing cause of nosocomial and antibiotic-resistant infections. Treating drug-resistant E. faecalis requires novel approaches. The use of bacteriophages (phages) against multidrug-resistant (MDR) bacteria has recently garnered global attention. Biofilms play a vital role in E. faecalis pathogenesis as they enhance antibiotic resistance. Phages eliminate biofilms by producing lytic enzymes, including depolymerases. In this study, Enterococcus phage vB_Efs8_KEN04 (ФKEN04), isolated from a sewage treatment plant in Nairobi, Kenya, was tested against clinical strains of MDR Enterococcus faecalis. This phage had a broad host range against 100% (26/26) of MDR E. faecalis clinical isolates and cross-species activity against Enterococcus faecium. It was able to withstand acidic and alkaline conditions, from pH 3 to 11, as well as temperatures between -80ᵒC and 37ᵒC. It could inhibit and disrupt the biofilms of MDR E. faecalis. Its linear double-stranded DNA genome of 142,402 bp contains 238 coding sequences with a G+C content and coding gene density of 36.01% and 91.46%, respectively. Genomic analyses showed that ФKEN04 belongs to the genus Kochikohdavirus in the family Herelleviridae. It lacked antimicrobial resistance, virulence, and lysogeny genes, and its stability, broad host range, and cross-species lysis indicate strong potential for the treatment of Enterococcus infections.
Lightweight Encoder with Attention Mechanism for Pipe Recognition Network
Authors: Tian Yang , Li Xinyu , Ma Shugen
Published: April 2024

Utilizing building information modeling (BIM) for the analysis of existing pipelines necessitates the development of a swift and precise recognition method. Deep learning-based object recognition through imagery has emerged as a potent solution for tackling various recognition tasks. However, the direct application of these models is unfeasible due to their substantial computational requirements. In this research, we introduce a lightweight encoder explicitly for pipe recognition. By optimizing the network architecture using attention mechanisms, it ensures high-precision recognition while maintaining computational efficiency. The experimental results showcased in this study underscore the efficacy of the proposed lightweight encoder and its associated networks.
Features of microstructure of carbide blanks
Authors: Khodosovskaya O. Yu. , Ovsyanikova L. V. , Gapeenko T. V.
Published: April 2024

The task of modern science and technology is to develop new and improve the characteristics of already used materials for the production of competitive products. Due to the reorientation of sales markets and the search for alternative suppliers of carbide tools, OJSC “BSW – Management Company of “BMK” Holding” began cooperation with Chinese firms‑manufacturers/ suppliers of carbide blanks. The article examines the features of the microstructure of carbide blanks. The blanks differ from the serially used blanks in microstructure, in particular, in the class of tungsten carbide grain. This is explained by the fact that grades of alloy with nanoscale tungsten carbide grain are used for the production of blanks to achieve the necessary durability during operation. The features in the microstructure of the hard alloy also led to changes in the “density” parameter towards reduction, which is also inherent in all Chinese blanks and does not affect their operational properties. Inhibitors of grain growth – transition metal carbides, for example, VC, Cr2C3, NbC, TaC are added to hard alloy mixtures to prevent grain growth during sintering. Recently, there has been a trend towards introducing TaC + TiC additives into WC–Co alloys, which prevent grain growth and have a negligible effect on all other properties of hard alloys.
. Structural aspects of the diverse formation of plastic properties of fine and coarse‑grained low‑carbon steel.
Authors: Fetisov V. P.
Published: April 2024

An increase in the relative elongation with an increase in the ferrite grain size is due to an increase in the intensity of deformation hardening in the area of uniform deformation. An increase in the relative narrowing with a decrease in the size of the ferrite grain is associated with the predominant direction of expansion of the central crack along the axis of tension and with a decrease in the intensity of deformation hardening in the area of local deformation.
Determination of Crack Resistance of the Cover and Slide Glass by Indentation Method with the Visualization Using Atomic Force Microscopy
Authors: Lapitskaya V. A. , Kuznetsova T. A. , Chizhik S. A.
Published: April 2024

Crack resistance of two types of glass was studied – cover glass (0.17 mm thick) and slide glass (2 mm thick) using an improved technique through the use of the probe methods, which makes it possible to increase the accuracy of determining the crack resistance of glass. Colorless silicate glass was used. Crack resistance was determined by the Vickers pyramid indentation method. Microstructure of glasses surface and deformation region after indentation were studied using an atomic force microscope. Mechanical properties of glasses were determined by nanoindentation. Surface relief of a glass slide is rougher than that one of a cover glass. Roughness Rz for a cover glass is less than for a slide glass. Specific surface energy value of 0.26 N/m is higher for the slide glass compared to the coverslip. One elastic modulus value E of the cover glass is 48 GPa, and that one of the slide glass is 58 GPa. The microhardness value H is almost the same for by the glasses and amounts to 6.7 GPa for a slide glass and 6.4 GPa for a cover glass. Atomic force microscope images of deformation region after indentation with a Vickers pyramid show that the first cracks appear at a load of 1 N on the slide glass, and at 2 N on the cover glass. At a load of 3 N, the cover glass is destroyed. Based on the results of crack resistance calculations it was found that critical stress intensity coefficient KIC values are 1.42 MPa∙m1/2 for a glass slide, and 1.10 MPa∙m1/2 for a cover glass.
Kinematic Features of Abrasive Processing of Lateral Surface of Flat-Convex Conical Lenses Using Free Rubbing Method
Authors: Kozeruk A. S. , Diaz Gonzales R. O. , Filonova M. I. , Kuznechik V. O. , Yurinok V. I.
Published: April 2024

A technology for three-support abrasive processing of flat-convex conical lenses using a tool with a stabilized flatness of the working surface is proposed, and a device diagram for implementing this technology is considered. The device contains a disk tool with a flat working surface, a straightener in the form of a glass plate with holes for parts, a drive for the rotational movement of the latter and a drive shaft for their reciprocating rotational movement. When using the device, the attachment of flat-convex conical lenses for their subsequent group processing occurs through optical contact based on mo-lecular adhesion forces. This blocking method increases the accuracy of processed parts and eliminates the use of adhesive resin, which, when heated, pollutes the environment with carcinogenic substances of the phenolic group. In addition, special compensators have been introduced into the design of the device to minimize the influence of vibrations in the “machine – fixture – tool – part” system, which helps to improve the accuracy parameters of plano-convex conical lenses. The paper presents results of a study of the influence of the nature of processing of the lateral surface of flat-convex conical lenses on the accuracy and productivity of the shaping process. The following cases are considered: with different orientations of the top of flat-convex conical lenses relative to the axis of symmetry of the tool, without forced and with forced rotation, with and without going beyond the edge of the tool during reciprocating rotational movement of workpieces along the working surface of the latter. It has been established that the accuracy of shaping and its productivity in the case of processing without parts lea-ving the edge of the tool are on average 30 % higher compared to the opposite situation, and processing with forced relative rotation of a block of parts increases their accuracy on average by one and a half times compared with  absence of such, while the internal orientation of flat-convex conical lenses (the top of the cone is directed towards the axis of rotation of the tool) helps to increase the intensity of stock removal by more than two times compared to their external orientation.
Сonstruction of Facades of Brick Buildings from Prefabricated Insulated Brick Panels (Piers) of Factory Manufacture
Authors: Chernoivan N. V.
Published: April 2024

The high labor intensity of constructing  insulated brick walls has led to a significant reduction in brick consumption in the Republic of Belarus. Considering that in each region there is at least one brick factory equipped with modern technological equipment, and the reserves of mineral raw materials (sand, clay) for making bricks are practically inexhaustible, the development of an effective structural and technological solution for insulated brickwork is an urgent task. As practice shows, today the majority of brick buildings being erected are low–rise (3-5 floors) – these are secondary schools, kindergartens, clinics, buildings for household purposes (laundries, dry cleaners, etc.), as well as administrative buildings. The floor layout of the premises of these buildings is, as a rule, cabinet (the number of window openings is significant). In this regard, it is proposed to use factory-made insulated brick panels (piers) to reduce the labor intensity of constructing the facades of such buildings. A distinctive feature of the proposed solution for insulated brickwork from those commonly used is that, to increase operational efficiency, it is made of two separate structural elements: load-bearing and heat-insulating and decorative. The paper describes in detail the organization and technology of work on the production of the main structural elements of brick insulated facade panels (piers) in factory conditions. The proposed design solution for the facade of brick buildings with a cabinet layout allows the manual technological process of constructing such buildings to be converted into a mechanized one – installation of factory-made insulated brick panels (piers), which will significantly reduce the labor intensity of constructing insulated brick walls. The division of buildings under construction into tiers, the height of which is linked to the range of technological operations and the building materials used, makes it possible to exclude from the work the use of lifting equipment (scaffolding), as well as the delivery of pallets with bricks and mortar boxes to the bricklayer's workplace.
O papel da construção de contexto na persuasão: um enfoque sistêmico-funcional
Authors: Ikeda Sumiko Nishitani , Bertelli Adriana Baldas Kutz
Published: April 2024

Um texto é tanto o produto quanto o gerador de contexto social. Muitos dos contextos sociais nos quais o ser humano passa o tempo são feitos unicamente pela língua. O presente estudo apresenta um exame crítico da persuasão decorrente dessa relação entre língua e contexto, em um artigo de opinião. Central para esta pesquisa é a implicação de que a língua é um “modo de ação” e não simplesmente uma “confirmação do pensamento”. A notícia é, assim, uma mercadoria simbólica na atividade de provedor de formas de consciência. O discurso da mídia é testemunho da crença de que notícias e outras formas desse discurso têm consequências. Esta pesquisa tem o apoio da proposta teórico-metodológica da Linguística Sistêmico-Funcional por meio da vertente da avaliatividade. O exame mostra que a construção adequada de contexto, com o apoio das noções de ironia e de frame, tem ação persuasiva, funcionando como um provedor de consciência.
A relação entre Voice e os particípios nas passivas: categorias mistas como recursos de reparo
Authors: Gonçalves Lydsson Agostinho , Armelin Paula Roberta Gabbai
Published: April 2024

Este trabalho investiga a voz passiva analítica, formada por um verbo finito e um particípio, numa perspectiva translinguística. O objetivo é derivá-la preservando uma relação com a passiva sintética, marcada por um clítico ou afixo. O trabalho se desenvolve sob o modelo da Morfologia Distribuída (Halle; Marantz, 1993). Parte-se de Gonçalves e Armelin (2021a, 2021b), que argumentaram que passivas sintéticas são formadas via a inclusão de um argumento default quando a estrutura possui o núcleo Voice, mas não possui argumento externo. Expandindo a análise para as analíticas, propomos que empregam outra estratégia para o mesmo contexto: a interrupção da projeção estendida do verbo, via merge de uma projeção mista (Panagiotidis, 2015), que se realiza como o particípio. A estrutura se torna nominal e, por isso, o argumento externo deixa de ser necessário. Uma nova projeção verbal se realiza como o auxiliar.
300-Year NH3 Inventory in Europe: Uncovering Combustion's Recent Share
Authors: Lamothe Alexis , Akers Pete , Ginot Patrick , Albertin Sarah , Eichler Anja , Gilbert Adrien , Caillon Nicolas , Gautier Elsa , Darfeuil Sophie , Savarino Joël
Published: April 2024

Today, anthropogenic emissions of ammonia (NH3) surpass natural emissions, causing profound impacts on radiative forcing, ecosystems, biodiversity, and human health1. Accurate estimates of emissions are imperative for effective mitigation. Currently, official NH3 inventories attribute around 95 % of European anthropogenic NH3 emissions to agriculture-related activities2, but a growing body of evidence suggests that these NH3 inventories may be inaccurate3. Here, we report the first glacially archived nitrogen isotope record for ammonium (the deposited form of NH3) from a Mont-Blanc ice core, offering an unprecedented glimpse into NH3 emissions spanning Western Europe’s pre-industrial era to the present day. This 300-year record reveals that anthropogenic NH3 emissions reflect the evolution of European economies, with the emergence of intensive agriculture and fossil fuel combustion. Most importantly, we show that, over the period 2010-2016, agriculture-related activities accounted for, at most, (78 ± 17) % of anthropogenic NH3 emissions, with the remainder being attributable to fossil fuel and biomass combustions. This less-than-assumed relative contribution from agricultural emissions strongly argue for a re-evaluation of NH3 inventories and unequivocally put forth that anthropogenic NH3 emissions cannot be reduced without limiting combustion-related activities.
FBXO28 promotes the malignancy of non-small cell lung cancer through ubiquitination-mediated activation of BRD4
Authors: Lv Xiao-Bin , Liang Yiping , Sun Longhua , Jiao Quanhui , Zhang Feifei , Bai Wei , Yang Jun , Luo Xiaohui , Zhang Jiongfeng , Qu Gaoyang , Tang Xiaofeng , Tang Jianjun , Zhang Zhiping , Lai Fenju , Cao Longhui
Published: April 2024

The E3 ubiquitin ligase FBXO28 has been implicated in the progression of various cancers, yet its precise function and substrates remain poorly understood. In this study, we investigated the role of FBXO28 in non-small cell lung cancer (NSCLC) and its impact on patient prognosis. We observed an upregulation of FBXO28 in NSCLC, and higher FBXO28 levels correlated with poorer patient outcomes. Functional experiments revealed that silencing FBXO28 inhibited NSCLC cell proliferation, migration, invasion, and induced apoptosis, while overexpression of FBXO28 had the opposite effects. Using tandem-affinity-purification mass-spectrum (TAP-MS) and co-immunoprecipitation (co-IP) assays, we identified an interaction between FBXO28 and BRD4. Further investigations showed that FBXO28 mediated the ubiquitination of BRD4 through a K63-conjugated model. This K63-conjugated ubiquitination of BRD4 appeared to influence the expression of genes targeted by BRD4, revealing FBXO28's role in mediating the transcriptional co-activation of BRD4. Mechanistically, FBXO28-mediated ubiquitination of BRD4 facilitates the activation of p-TEFb and subsequent phosphorylation of the serine 2 (Ser2) C-terminal domain (CTD) of the largest subunit of RNA polymerase II (RNAPII), initiating transcription. Besides, FBXO28 was found to promote the formation of liquid-liquid phase separation within the BRD4 complex, potentially enhancing transcription. Furthermore, in a positive feedback loop, we discovered that BRD4 bound to the FBXO28 promoter and increased the transcription of FBXO28. In summary, our findings highlight the pivotal role of the FBXO28/BRD4 positive feedback loop in driving the malignancy of NSCLC.
Evaluating the impact of delayed study startup on accrual in cancer studies
Authors: Ratnayake Isuru Panduka , Do Anh-Tuan , Gajewski Daniel , Pepper Sam , Ige Oluwatobiloba , Streeter Natalie , Lin Tara L. , McGuirk Matthew , Gajewski Byron , Mudaranthakam Dinesh Pal
Published: April 2024

Background: Drug development in cancer medicine depends on high-quality clinical trials, but these require large investments of time to design, operationalize, and complete; for oncology drugs, this can take 8-10 years. Long timelines are expensive and delay innovative therapies from reaching patients. Delays often arise from study startup, a process that can take 6 months or more. We assessed how study-specific factors affected the study startup duration and the resulting overall success of the study.
Method: Data from The University of Kansas Cancer Center (KUCC) were used to analyze studies initiated from 2018 to 2022. Accrual percentage was computed based on the number of enrolled participants and the desired enrollment goal. Accrual success was determined by comparing the percentage of enrollments to predetermined threshold values (50%, 70%, or 90%).
Results: Studies that achieve or surpass the 70% activation threshold typically exhibit a median activation time of 140.5 days. In contrast, studies that fall short of the accrual goal tend to have a median activation time of 187 days, demonstrating the shorter median activation times associated with successful studies. Wilcoxon rank-sum test conducted for the study phase (W=13607, p-value=0.001) indicates that late-phase projects took longer to activate compared to early-stage projects. We also conducted the study with 50% and 90% accrual thresholds; our findings remained consistent.
Conclusions: Longer activation times are linked to reduced project success, and early-phase studies tend to have higher success than late-phase studies. Therefore, by reducing impediments to the approval process, we can facilitate quicker approvals, increasing the success of studies regardless of phase.
Controllable Chiral Lattices for 2D ROA Mapping and a Long-term Stable Broadband CPL Detector
Authors: Yeom Jihyeon , Kwon Junyoung , Jeon Jae Bum , Choi Won Jin , Jeong Uichang , Jung Wookjin , Kim Kyung Min
Published: April 2024

Circularly polarized light (CPL)-sensitive detector enables various techniques such as quantum computing, spin optical communications, and magnetic recording. However, limited responsive wavelength range and low stability of the common CPL detecting materials have hindered explosive applications of CPL detectors. Here, we introduce atomic chiral Se nanorods films as a broadband CPL detector, taking advantage of the intrinsic atomic chirality and the stability of inorganic Se nanocrystals. An incident circular polarization (ICP)-Raman optical activity (ROA) mapping technique is also performed to examine the chiroptical activity of the large-area CPL detecting films. This ROA mapping technique is firstly presented with our knowledge as a new analytic method for chirality of 2D materials. The monolayered Se NRs detect circularly polarized light in broad wavelengths from UV to SWIR with the responsivity dissymmetry factor (gres) up to 0.4 with high stability at ambient conditions for longer than 1 year. The CPL-sensitive Se NRs will also be employed in various applications, such as chiral photonic synapses, chiral spin devices, and CPL-sensitive photocatalysts. Furthermore, our ICP-ROA mapping technique will open a new door to the development and analysis of 2D chiral materials.
Analysis of the disease burden of rare disorders among children: a single-center study from western China
Authors: Xiao Liping , Chi Huan , Liu Guiqi , Liang Xiaohua , Li Qiu , Zeng Huasong , Zhou Juan
Published: April 2024

Objective
To analyze the disease profiles and associated burdens of hospitalized children with rare disorders. Study design: Clinical data of 1,975 children hospitalized with rare disorders from 2012 to 2018 at a single medical center in western China were retrospectively analyzed. A family-structured questionnaire survey was conducted on 200 children with 10 of these diseases, capturing demographic information, family economic status, disease costs, compliance behavior, outpatient and inpatient service use, and the psychological burden of parents.
Results: The male-to-female ratio among the children was 1.71:1. The majority were infants and children aged 0–3 years (43.75%), and predominantly from urban areas (74.03%). In total, 48 rare disorders, classified into 10 types, were identified. Diseases of the blood and hematopoietic organs, and certain disorders involving immune mechanisms, were the most prevalent type (31.04%). Significant differences were observed in the duration of hospital stays and treatment and examination costs for different rare childhood disorders (P < 0.001). Circulatory diseases incurred the highest overall hospitalization costs, whereas diseases of the blood and hematopoietic organs, and immune mechanism disorders had the highest treatment costs (72.19%). Endocrine, nutritional, and metabolic diseases accounted for the highest examination costs (57.32%).
Conclusion: Rare disorders in children are highly variable, with complex disease characteristics, underscoring the need for individualized medical approaches for diagnosis and treatment. Enhanced genetic counseling and eugenics guidance, improved health insurance policies, structured diagnosis and treatment strategies, and emphasis on the psychological well-being of affected families can help reduce the disease burden.
Immobilization coupling with aptamer assisted dual cycle amplification for sensitive exosome isolation and analysis
Authors: He Yu , Ren Ying , Tang Jiawen
Published: April 2024

Purpose
Precise identification of exosomes is crucial for improving disease diagnosis and treatments. However, accurate isolation and simultaneously quantification of exosomes remain a huge challenge. We have introduced a new technique that combines immobilization with aptamer-assisted dual cycle amplification to isolate and analyze exosomes with high sensitivity.
Methods
In this method, the CD9 protein antibody is attached to the plate's surface for the initial identification of exosomes, while an aptamer probe is used to detect the exosomal surface protein CD63. We have created an exosome-surface method that combines target recognition initiated signal recycling and rolling circle amplification (RCA) for signal amplification. This approach allows for the “AND” logic analysis of dual biomarkers, enabling both exosome quantification and tracing.
Results
The proposed approach has a broad detection range and a low limit of detection. Moreover, the established method showed good stability in detecting exosomes with a low coefficient of variation.
Conclusion
Our method can effectively isolate certain exosomes and accurately identify them, making it suitable for many uses in biological science, biomedical engineering, and personalized medicine.
A novel transdermal drug delivery system: drug-loaded ROS-responsive ferrocene fibers for effective photoprotective and wound healing activity
Authors: Kim Sangwoo , Kim Yoon , Kim Chaehyun , Choi Won Il , Kim Byoung Soo , Hong Jinkee , Lee Hoik , Sung Daekyung
Published: April 2024

Herein, we developed an innovative transdermal drug delivery system utilizing electrospinning technology. The system employs reactive oxygen species (ROS)-responsive drug-loaded ferrocene-based polymer fibers (FPF), with ascorbyl tetraisopalmitate (AT) as the loaded drug. These fibers offer superior drug protection from external factors, exhibit a high loading efficiency (~ 70 wt%), and enable controlled drug release under high ROS conditions, such as wounds. The transition from the hydrophobic to hydrophilic state, triggered by ROS, ensures precise drug release. Scanning electron microscopy confirmed ROS-responsiveness, whereas DPPH and DCFDA assays demonstrated antioxidant activity. Furthermore, cell proliferation and wound healing efficacy assessments validated the advantages of AT-loaded FPFs via the CCK-8 and scratch assays. This pioneering approach promises to revolutionize transdermal therapeutics, particularly in wound healing, by providing unparalleled precision and efficiency in drug delivery. The development of drug-loaded ferrocene fibers represents a groundbreaking advancement in stimuli-responsive drug delivery systems, marking a significant milestone in the field.
Utilization of Natural Kapok and Coconut Fiber in Thermally Insulated Sustainable Concrete Design
Authors: Susurluk Gulsah , Sarıkaya Hakan , Bostanci Levent
Published: April 2024

Nowadays, when regenerable alternative green sources are attracting more caution under sustainability targets, kapok and coconut fibers, known as natural fibers, have come to the fore as a very significant raw material source. In this experimental study, compressive strength, thermal insulation and pore structure characteristics of kapok fiber (KP) and coconut fiber (CC)-incorporated concrete samples under different curing conditions were analyzed. For that purpose, randomly distributed fiber-incorporated concrete mixtures containing 0%, 0.5%, 1% and 1.5% KP and CC fiber by the weight of cement were prepared and under H2O2 and NaClO curing conditions, the effects of KP and CC fiber inclusion on properties mentioned above of fiber-incorporated concrete samples were researched in detail. Experimental results depict that a maximum thermal conductivity coefficient decrease of 24.31% was detected at a content ratio of 1.5% by the reason of the pore modification effect of used natural fibers in the H2O2 curing group. Because of the remarkable pore modification effect of KP fiber incorporation into the cement matrix compared to the CC fiber inclusion cases, strong linear correlations revealing the insulation-strength mechanism could be detected for both H2O2 and NaClO curing cases. This work intends to promote sustainable development in the building industry by integrating natural fibers into concrete mixtures as an innovative design approach.
Research of the compositional characteristics of antibiotic resistance genes in sediments from the Three Gorges Reservoir area
Authors: Han Chang , Cao Huiqun , Tan Haoyue , Li Xiaomeng , Yang Wenjun
Published: April 2024

Antimicrobial resistance genes (ARGs) are widespread across various regions. While several studies have investigated the distribution of antibiotic resistance in natural environments, the occurrence and diversity of ARGs in the Three Gorges Reservoir have not been fully elucidated. In this study, we employed metagenomic sequencing techniques to investigate the abundance, diversity, and influencing factors of ARGs in the ecosystem of the Three Gorges Reservoir. A total of 874 ARGs, 20 antibiotic classes against which resistance genes are deployed, and 6 resistance mechanisms were detected. The dominant ARG is the macB gene, the dominant antibiotic class is multidrug resistance (MDR), and the dominant resistance mechanism is antibiotic efflux. The microorganisms with the highest contribution to ARGs are Betaproteobacteria and Gammaproteobacteria, while physicochemical factors have little impact on the distribution of ARGs. The results indicate that the Three Gorges Reservoir constitutes a significant reservoir of ARGs. By examining the distribution of ARGs in the sediments of the Three Gorges Reservoir and the associated characteristics between microorganisms and ARGs, we aim to understand the current state of resistance pollution in the Three Gorges region, thereby providing theoretical support for risk assessment of resistance genes in the environment.
Molecular mechanism of PPMlJ regulates broiler skeletal muscle development and glycerophospholipids composition based on phosphoproteomic and metabolome.
Authors: Cai Bolin , Ma Manting , Yang Xin , Zhang Yanan , Wang Shuang , Jin Chenglong , Xia Weiguang , Chen Wei , Zheng Chuntian
Published: April 2024

The quality of broiler meat affects consumers’ purchasing decisions. Numerous studies have shown that phosphorylation of proteins in muscle can affect muscle quality. Here, metabolomics and transcriptomics were used to systematically identify the genetic regulation of differences in meat flavor among different broiler. By constructing the meat flavor-related metabolite-gene networks, we identified that protein phosphatase magnesium/manganese-dependent 1J (PPM1J), which is known to regulate a range of biological processes by modulating reversible protein phosphorylation, was a differentially expressed gene with the highest connectivity to meat flavor-related metabolites. PPM1J facilitated the proportion of small myofiber (≤ 250 µm2) and regulated the composition of glycerophospholipids. More importantly, phosphoproteomic and metabolome results found that PPM1J participates in the regulation of skeletal muscle development and glycerophospholipids composition by catalyzing protein dephosphorylation. Our study provides a basis for further understanding the molecular mechanism of skeletal muscle development and glycerophospholipids composition in broiler.