bluuebunny/crossref_metadata_2025 huggingface dataset:
Tier-based antimicrobial stewardship metrics for genitourinary-related antibiotic use in Veterans’ Affairs outpatient settings
Authors: Samore Matthew , Goetz Matthew , Nevers McKenna , Crook Jacob , Rovelsky Suzette , Brintz Ben , Echevarria Kelly , Neuhauser Melinda , Tsay Sharon , Hicks Lauri , Madaras-Kelly Karl
Published: May 2022

Background: Tracking antibiotic use is a core element of antimicrobial stewardship. We developed a set of metrics based on electronic health record data to support an outpatient stewardship initiative to improve management of urinary tract infections (UTIs) in Veterans’ Affairs (VA) emergency departments (EDs) and primary care clinics. Because UTI diagnostic codes only capture a portion of genitourinary (GU)-related antibiotic use, a tier-based approach was used to evaluate practices. Methods: Metrics were developed to target practices related to antibiotic prescribing and diagnostic testing (Table 1). GU conditions were divided into 3 categories: tier 1, conditions for which antibiotics are usually or always indicated; tier 2, conditions for which antibiotics are sometimes indicated; and tier 3, conditions for which antibiotics are rarely or never indicated (eg, benign prostatic hypertrophy with symptoms). Patients with visits related to urological procedures, nontarget providers, and concomitant non-GU infections were excluded. Descriptive analyses included calculation of the correlation matrix for the 7 metrics and the construction of box plots to display interfacility variability. Results: Metrics were calculated quarterly for 18 VA medical centers, including affiliated clinics, in a western VA network, from July 2018 to June 2020 (Table 1). Tier 3 GU conditions accounted for 1,276 of 11,840 (11%) of GU-related antibiotic use. Metrics 1 and 6b were strongly correlated with each other and were also positively correlated with metrics 2 and 5 (coefficients > 0.5) (Fig. 1). Substantial interfacility variation was observed (Fig. 2). Conclusions: Stewardship metrics for suspected or documented UTIs can identify opportunities for practice improvement. Broadly capturing GU conditions in addition to UTIs may enhance utility for performance feedback. Antibiotic prescribing for tier 3 GU conditions is analogous to unnecessary antibiotic use for acute, uncomplicated bronchitis and upper respiratory tract infections.

Funding: None

Disclosures: None
Analysis of Universal admission laboratory screening for SARS-CoV-2 asymptomatic infection across a large health system
Authors: Cihlar Jennifer , Harris Bryan , Wright Patty , Humphries Romney , (Caroline) Kelly , Cherry Brandi , Talbot Thomas
Published: May 2022

Background: Admission laboratory screening for asymptomatic COVID-19 has been utilized to mitigate healthcare-associated SARS-CoV-2 transmission. A better understanding of the impact of such testing across a variety of patient populations is needed. Methods: Beginning April 2020, every patient admitted within an academic healthcare system underwent SARS-CoV-2 PCR testing upon admission. Between April 20, 2020 through June 14, 2021, results were analyzed in asymptomatic patients across 4 inpatient facilities: a tertiary-care adult hospital, a free-standing pediatric hospital, a community-based hospital, and a behavioral health hospital. Positivity rates and the number needed to test (NNT) to identify 1 asymptomatic infected patient were calculated overall, by hospital type, by patient vaccination status, and by CDC-defined levels of community transmission. Weekly community incidence rates of COVID-19 for the system’s metropolitan service area (8 central Tennessee counties) were obtained from Tennessee Department of Health records. Weekly COVID-19 incidence rates per 100,000 people were calculated using US Census Bureau data. Using a national survey of hospital epidemiologists, a clinically meaningful NNT was identified (ie, 1 positive patient per 100 patients tested). A crude admission testing cost (covering testing supplies, reagents, and lab personnel costs) was obtained from operational data ($50 per test) to assess testing utility. Results: In total, 51,187 tests were collected during the study period with a positivity rate of 1.8%. No periods of low transmission were observed (Table 1). During high transmission periods, the NNT met the clinically relevant threshold in all populations. In addition, the NNT approached or met the 1:100 threshold for most locations during periods of less transmission, suggesting continued benefit even as infection rates decline. In all transmission periods, the NNT for non–fully vaccinated patients met the clinically meaningful threshold, in contrast to testing of fully vaccinated patients (Table 2). Discussion: Implementing an asymptomatic patient admission testing program can provide clinically relevant value based on the NNT, even during lower periods of transmission and in different patient populations. Limiting admission testing to non–fully vaccinated patients during periods of lower transmission may be a strategy to address cost and resource concerns around this practice. Further investigations into the impact of booster vaccination and newer SARS-CoV-2 variants on admission testing programs are also necessary. Although the impact of such testing on healthcare-associated COVID-19 among patients and healthcare workers could not be clearly determined, these data provide important information as facilities weigh the costs and benefits of such testing.

Funding: None

Disclosures: None
Outbreak response activities conducted by public health programs in healthcare facilities nationwide, August 2019–July 2020
Authors: Shrivastwa Nijika , Ochoa Lucas , Walters Maroya , Perkins Kiran , Perz Joseph , Hunter Jennifer C.
Published: May 2022

Background: Rapid response is critical to control healthcare-associated infection (HAI) and antibiotic resistance threats within healthcare facilities to prevent illness among patients, residents, and healthcare personnel. Through this analysis, we aimed to quantify public health response activities, by healthcare setting type, for (1) novel and targeted multidrug-resistant organisms or mechanisms (MDROs), (2) SARS-CoV-2, and (3) other possible outbreaks. Method: We reviewed response activity data submitted by US state, territorial, and local health department HAI/AR programs to the CDC as part of funding requirements. We performed descriptive analyses of response activities conducted during the funding reporting period (August 2019–July 2020). SARS-CoV-2 response activities were reported from January through July 2020. Data were analyzed by response category (novel or targeted MDRO, SARS-CoV-2, other HAI/AR responses), and healthcare setting type. Results: During August 2019–July 2020, 57 HAI/AR Programs (50 state, 1 territorial, 5 local health departments, and District of Columbia) reported 18,306 public health responses involving healthcare facilities. These data included 3,860 responses to 1 or more cases of novel or targeted MDROs, 13,992 responses to SARS-CoV-2 outbreaks (beginning in January 2020), and 454 responses to other possible outbreaks. Novel and targeted MDRO responses most frequently occurred in acute-care hospitals (ACHs, 64.5%), skilled nursing facilities (SNFs, 24.5%), and long-term acute-care hospitals (LTACHs, 5.8%). SARS-CoV-2 responses most frequently occurred in SNFs (55%), and assisted living facilities (24%). Other HAI/AR responses most frequently occurred in ACH (50%), SNF (28.4%), and outpatient settings (19.6%). Of the “other” HAI/AR responses, 76% were responses to cases, clusters, or outbreaks, and 23.8% were responses to serious infection control breaches including device and instrument reprocessing, injection safety, and other deficient practices. Conclusions: During the study period, public health programs performed a high volume of HAI/AR response activities largely focused on SARS-CoV-2 in nursing homes and assisted living facilities. Other important response activities occurred across a range of other healthcare settings, including responses to novel and targeted MDROs, HAI outbreaks, and serious infection control breaches. Whereas SARS-CoV-2 response activities largely centered in long-term care settings, MDRO and other HAI/AR responses occurred mostly in acute-care settings. These data demonstrate the importance of building and sustaining public health response capacity for a broad array of healthcare settings, pathogens, and patient populations to meet the range of current and emerging HAI/AR threats.

Funding: None

Disclosures: None
Effect of the COVID-19 pandemic on Tennessee hospital antibiotic use
Authors: Ouedraogo Youssoufou , Evans Christopher , Muleta Daniel , Wilson Christopher
Published: May 2022

Background: On March 5, 2020, the Tennessee Department of Health (TDH) announced the first case of COVID-19 in the state. Since then, hospitals have been overwhelmed by the spike in respiratory infections. Several studies have attempted to describe the impact of the pandemic on antibiotic prescriptions. The NHSN Antimicrobial Use Option offers a platform for hospitals to report their antibiotic usage. The TDH has established access to hospital antibiotic usage data statewide through an existing NHSN user group. We compared the change in the volume of inpatient antibiotic prescriptions before and during the pandemic. Methods: An ecological study was conducted from January 2019 to December 2021. Aggregated facility-level data from the NHSN Antimicrobial Use Option were used to describe antibacterial use among Tennessee hospitals. Data from facilities that had reported at least 1 month of data during the study period were included in this study. The antimicrobial use rate was calculated by dividing the antimicrobial days of therapy (DOT) by the number of 1,000 days present. Overall antimicrobial use rates as well as specific antimicrobial use rates for azithromycin, ceftriaxone, and piperacillin–tazobactam were compared across years. Results: In total, 55 hospitals reported at least 1 month of data into the NHSN Antimicrobial Use Option during the study period. These hospitals had a median bed size of 140 (range, 12–689). Conclusions: We observed a modest increase in overall antibiotic use during the COVID-19 pandemic in Tennessee facilities. This trend appeared to be primarily attributed to agents used for community-acquired respiratory infections, such as azithromycin and ceftriaxone, earlier in the pandemic. However, both of these agents have fallen to prepandemic use levels during 2021. The fact that overall use increased in 2021 suggests that other agents not analyzed may have contributed to this effect. Further analysis may help determine which agents are responsible for this increase in 2021.

Funding: None

Disclosures: None
Leukotriene inhibitors with dexamethasone show promise in the prevention of death in COVID-19 patients with low oxygen saturations
Authors: Elkin Peter L. , Resendez Skyler , Mullin Sarah , Troen Bruce R. , Mammen Manoj J. , Chang Shirley , Franklin Gillian , McCray Wilmon , Brown Steven H.
Published: May 2022

Introduction:

COVID-19 is a major health threat around the world causing hundreds of millions of infections and millions of deaths. There is a pressing global need for effective therapies. We hypothesized that leukotriene inhibitors (LTIs), that have been shown to lower IL6 and IL8 levels, may have a protective effect in patients with COVID-19.

Methods:

In this retrospective controlled cohort study, we compared death rates in COVID-19 patients who were taking a LTI with those who were not taking an LTI. We used the Department of Veterans Affairs (VA) Corporate Data Warehouse (CDW) to create a cohort of COVID-19-positive patients and tracked their use of LTIs between November 1, 2019 and November 11, 2021.

Results:

Of the 1,677,595 cohort of patients tested for COVID-19, 189,195 patients tested positive for COVID-19. Forty thousand seven hundred one were admitted. 38,184 had an oxygen requirement and 1214 were taking an LTI. The use of dexamethasone plus a LTI in hospital showed a survival advantage of 13.5% (CI: 0.23%–26.7%; p < 0.01) in patients presenting with a minimal O2Sat of 50% or less. For patients with an O2Sat of <60 and <50% if they were on LTIs as outpatients, continuing the LTI led to a 14.4% and 22.25 survival advantage if they were continued on the medication as inpatients.

Conclusions:

When combined dexamethasone and LTIs provided a mortality benefit in COVID-19 patients presenting with an O2 saturations <50%. The LTI cohort had lower markers of inflammation and cytokine storm.
From Algiers to Timbuktu: Multi-Local Research in Colonial History Across the Saharan Divide
Authors: Anderson Samuel D.
Published: May 2022

The so-called “Saharan Divide” separating sub-Saharan Africa and North Africa into distinct fields has a long and complicated history. Paradoxically, given its dense historiography, this divide is particularly pronounced in scholarship on the colonial period. This article proposes an approach to researching across this division, centered on research in multiple African archives, to build a “multi-local” understanding of colonial-era trans-Saharan Africa. This approach is illustrated by the story of Algerians who taught in colonial schools in Mauritania and French Soudan, and by the author’s discovery of this story in sites across northwest Africa. This approach can help scholars reconceptualize multi-sited research and reevaluate the Area Studies divisions that continue to structure knowledge of African history.
Colloidal exchange flow in ducts
Authors: Alba K.
Published: May 2022

Buoyancy-driven exchange flow, i.e. drainage of a heavy colloidal suspension by an immiscible light pure fluid in a vertical duct, is studied analytically. A lubrication model is developed for two-dimensional channel and axisymmetric pipe geometries. The outcome transport equations are solved numerically to capture the effect of important governing dimensionless parameters: Péclet number, precursor film thickness, Reynolds number, mixtures’ viscosity ratio, initial volume fraction of hard-sphere particles, particles concentration within the precursor film, and capillary number. Recent study of colloidal film flow over a flat surface reveals interface thinning over time due to diffusion impact on suspension viscosity. However, the current model suggests that there is no such thinning phenomenon observed for colloidal flows within confined geometry unless in the absence of surface tension. The extent of the mixed particle zone along the duct grows as the Péclet number is decreased. Precursor film thickness is found to decrease the capillary ridge height forming at heavy suspension front. Either an increase in the Reynolds number or a decrease in light-to-heavy-fluid viscosity ratio extends the interpenetration rate of mixtures. As the bulk volume fraction of particles is increased close to 50 %, interesting secondary fronts emerge within the flow that coincide with the range where the diffusion coefficient is minimized. The heavy suspension layer drains slightly faster when the gradient in particle concentration between the bulk and precursor film regions is maximum. Finally, the non-monotonic impact of surface tension on the extent of mixtures’ exchange zone is uncovered via simulations conducted at various capillary numbers.
Effect of relational capability on dynamic capability: exploring the role of competitive intensity and environmental uncertainty
Authors: Singh Ritu , Charan Parikshit , Chattopadhyay Manojit
Published: May 2022

This study empirically examines the role of market dynamism and a firm's relational capability in the development of dynamic capability. A moderated hierarchical regression method has been used on the survey data of 218 Indian firms to test the objectives of the study. The findings suggest that relational capability (namely, customer linking capability and strategic partnering capability) is an important driver of dynamic capability. However, the effectiveness of relational capability is dependent on the market dynamism; particularly, when competition intensifies, the impact of customer linking capability declines, whereas the impact of strategic partnering capability on dynamic capability becomes stronger. Furthermore, the finding suggests that even though environmental uncertainty represents an important element of market dynamism, it is a driver, rather than a moderator, of dynamic capability. The study contributes to the extant literature by explicitly specifying the relational capability as a specific competence to develop dynamic capability under different market conditions.
The Importance of the Promotion of Evidence-Based Practice as a Reasonable Adjustment in Mainstream Education Settings for Students With Autism Spectrum Disorder
Authors: Garrad Traci-Ann , Vlcek Samantha , Page Angela
Published: May 2022

Autism spectrum disorder (ASD) is a neurodevelopmental condition that can affect a person’s ability to manage the complexities of varied social and environmental situations. This is particularly evident in the dynamic context of a school classroom. To assist students with ASD to navigate the complexities of Australian primary and secondary mainstream classrooms, educators are required to provide ‘reasonable adjustments’ to support learning; that is, to make changes that are practicable and achievable in order for students to access learning on the same basis as their peers. We present an argument that the ‘reasonable adjustments’ made by schools to ensure that students with ASD have equitable learning opportunities should meet a criterion of acceptability where the adjustment is evidence based. The paper also offers a summary of evidence-based pedagogical strategies that have been effective for students with ASD and concludes with a discussion offering evidence-based practices as a solution to meeting legislative requirements for students with disability.
Unraveling the force dynamics in conceptual metaphors of COVID-19: a multilevel analysis
Authors: Kazemian Reza , Rezaei Hadaegh , Hatamzadeh Somayeh
Published: May 2022

So far, cognitive linguistics studies on COVID-19 have focused mainly on conceptual metaphors, paying scant attention to other construal operations such as force dynamics (FD). Adopting Kövecses’s (2020, Rivista Italiana di Filosofia del Linguaggio) hybrid account of conceptual metaphor and FD, this study attempts to outline an enriched cognitive view of the figurative conceptualization of illness. It also aims to answer the question: Can FD and conceptual metaphors be merged in illness metaphors, particularly corona-related ones? Research in cognitive linguistics has focused on certain source domains, such as war, fire, natural force, and wild animal, through which COVID-19 is conceptualized metaphorically. Since these metaphors feature the exchange of forces and actions, a more detailed account of these two construals could be fruitful, especially the potential force schema which underlies the detected source domains. Using an amalgamated model of conceptual metaphor theory and FD, significant associations were identified between two force-exerting elements, namely Agonist and Antagonist. These findings raise important theoretical issues that have a bearing on clarifying the correlation between illness metaphors and Talmy’s force-dynamic theory to cast some light on the complex metaphorical expressions embracing the subject under scrutiny.
Protests in Postwar Societies: Grievances and Contentious Collective Action in Kosovo
Authors: Kelmendi Pëllumb , Skendaj Elton
Published: May 2022

Most research on protests has been conducted in peaceful societies, whereas we know far less about contentious collective action in postwar contexts. To fill this gap, we offer a theory that perceived ethnic grievances related to group security and group status are particularly likely to generate protest mobilization in postwar societies. To test this theory and alternative hypotheses, we investigate trends in protest behavior in postwar Kosovo using an original protest event dataset and existing survey data. We find that protest behavior in postwar Kosovo is significantly shaped by perceived ethnic grievances: the majority of protest grievances center around group security and group status concerns. Protests about economic justice or good governance demands are significantly rarer. Using data from existing surveys, we also investigate the determinants of variation in individual protest participation. Our analysis reveals that perceived ethnic discrimination is strongly associated with individual protest participation in Kosovo.
THE FIRST RADIOCARBON-DATED REMAINS OF THE LEOPARD PANTHERA PARDUS (LINNAEUS, 1758) FROM THE PLEISTOCENE OF POLAND
Authors: Marciszak Adrian , Lipecki Grzegorz , Gornig Wiktoria , Matyaszczyk Lena , Oszczepalińska Oliwia , Nowakowski Dariusz , Talamo Sahra
Published: May 2022

The Pleistocene history of the leopard (Panthera pardus) in Europe has been documented by the material obtained from 312 localities, with the last dated ∼1.1 Myr. The relatively small and gracile form of the leopard was very rare during the late Early and Middle Pleistocene. Only after the disappearance of the jaguar (Panthera gombaszoegensis) did P. pardus spread widely in Europe, increasing in size and ecologically substituting P. gombaszoegensis. The number of late Middle Pleistocene localities with leopard remains, younger than 300 kyr, increased considerably. The leopard reached the maximum extension of its geographical range in the Late Pleistocene. The Iberian Peninsula was the last European refuge for this cat. Six sites, the Naciekowa, Obok Wschodniej, Radochowska, and Wschodnia Caves from the Sudety Mountains and the Biśnik and Dziadowa Skała Caves from the Kraków-Częstochowa Upland, have documented the presence of the leopard in Poland between MIS 10/9 and MIS 3. These records are from rocky regions with rugged terrain and are located in the territory of Silesia (southern Poland). A newly obtained radiocarbon date (43–42 kyr) from the Radochowska Cave directly confirms the occurrence of P. pardus in the Sudety Mountains in the middle part of MIS 3.
White Americans’ Reactions to Racial Disparities in COVID-19
Authors: STEPHENS-DOUGAN LAFLEUR
Published: May 2022

I fielded a survey experiment on a nationally representative sample of 591 white Americans to test whether exposure to information about the disparate impact of COVID-19 on Black people influenced white Americans’ opinion about COVID-19 policies. I found that racially prejudiced white Americans who were exposed to the treatment diminished the importance of wearing a face mask. They also became more supportive of outdoor activities without social distancing guidelines, more likely to perceive shelter-in-place orders as a threat to their individual rights and freedoms, and less likely to perceive African Americans as following social distancing guidelines. Conversely, white Americans who did not endorse an anti-Black stereotype were less likely to perceive shelter-in-place orders as a threat to their individual rights and more likely to perceive African Americans as following social distancing guidelines. These findings highlight that well-intentioned public health campaigns may inadvertently exacerbate existing race-based health disparities.
Uneasy Neighbors: The Making of Sectarian Difference and Alevi Precarity in Urban Turkey
Authors: Gökarıksel Banu , Secor Anna J.
Published: May 2022

This study takes a critical perspective on the making of sectarian difference and Alevi precarity in contemporary Turkey. Drawing on our research from 2013 to 2016, we present an analysis of stories and conversations that took place amongst Alevi and Sunni focus group participants, primarily in Istanbul. These conversations illustrate how sectarian difference can be made in the relations between neighbors as differences become coded as sectarian and taken up within systems of power and domination. At the same time, our research also shows how, in the entangled relations between neighbors, questions of ethics and mutual responsibility arise, though these relations sometimes become uneasy or even unbearable. Finally, we show how the question of “knowing” difference is taken up within a power-laden discourse of sectarianism, one that is tied to the history of Alevis (and others) in Turkey while also extending well beyond this context.
Contrasting temperature responses in seasonal timing of cercariae shedding by Rhipidocotyle trematodes
Authors: Taskinen Jouni , Choo Jocelyn M. , Mironova Ekaterina , Gopko Mikhail
Published: May 2022

Global warming is likely to lengthen the seasonal duration of larval release by parasites. We exposed freshwater mussel hosts, Anodonta anatina, from 2 high-latitude populations to high, intermediate and low temperatures throughout the annual cercarial shedding period of the sympatric trematodes Rhipidocotyle fennica and R. campanula, sharing the same transmission pathway. At the individual host level, under warmer conditions, the timing of the cercarial release in both parasite species shifted towards seasonally earlier period while its duration did not change. At the host population level, evidence for the lengthening of larvae shedding period with warming was found for R. fennica. R. campanula started the cercarial release seasonally clearly earlier, and at a lower temperature, than R. fennica. Furthermore, the proportion of mussels shedding cercariae increased, while day-degrees required to start the cercariae shedding decreased in high-temperature treatment in R. fennica. In R. campanula these effects were not found, suggesting that warming can benefit more R. fennica. These results do not completely support the view that climate warming would invariably increase the seasonal duration of larval shedding by parasites, but emphasizes species-specific differences in temperature-dependence and in seasonality of cercarial release.
Context-dependent parasite infection affects trophic niche in populations of sympatric stickleback species
Authors: Thorburn Doko-Miles J. , Bal Thijs M. P. , Deflem Io S. , Volckaert Filip A. M. , Eizaguirre Christophe , Raeymaekers Joost A. M.
Published: May 2022

How parasites alter host feeding ecology remains elusive in natural populations. A powerful approach to investigate the link between infection and feeding ecology is quantifying unique and shared responses to parasite infection in related host species within a common environment. Here, 9 pairs of sympatric populations of the three-spined and nine-spined stickleback fishes were sampled across a range of freshwater and brackish habitats to investigate how parasites alter host feeding ecology: (i) biotic and abiotic determinants of parasite community composition, and (ii) to what extent parasite infection correlates with trophic niche specialization of the 2 species, using stable isotope analyses (δ15N and δ13C). It was determined that parasite community composition and host parasite load varied among sites and species and were correlated with dissolved oxygen. It was also observed that the digenean Cyathocotyle sp.'s abundance, a common directly infecting parasite with a complex life cycle, correlated with host δ13C in a fish species-specific manner. In 6 sites, correlations were found between parasite abundance and their hosts' feeding ecology. These effects were location-specific and occasionally host species or host size-specific. Overall, the results suggest a relationship between parasite infection and host trophic niche which may be an important and largely overlooked ecological factor. The population specificity and variation in parasite communities also suggest this effect is multifarious and context-dependent.
Unique genetic structure of the human tapeworm Dibothriocephalus latus from the Alpine lakes region – a successful adaptation?
Authors: Radačovská Alžbeta , Čisovská Bazsalovicsová Eva , Šoltys Katarína , Štefka Jan , Minárik Gabriel , Gustinelli Andrea , Chugunova Julia K. , Králová-Hromadová Ivica
Published: May 2022

Dibothriocephalus latus is the most frequent causative agent of fish-borne zoonosis (diphyllobothriosis) in Europe, where it is currently circulating mainly in the Alpine lakes region (ALR) and Russia. Three mitochondrial genes (cox1, cob and nad3) and 6 microsatellite loci were analysed to determine how is the recently detected triploidy/parthenogenesis in tapeworms from ALR displayed at the DNA level. A geographically distant population from the Krasnoyarsk Reservoir in Russia (RU-KR) was analysed as a comparative population. One or 2 alleles of each microsatellite locus was detected in plerocercoids from RU-KR, corresponding to the microsatellite pattern of a diploid organism. In contrast, 1–3 alleles were observed in tapeworms from ALR, in accordance with their triploidy. The high diversity of mitochondrial haplotypes in D. latus from RU-KR implied an original and relatively stable population, but the identical structure of mitochondrial genes of tapeworms from ALR was probably a consequence of a bottleneck typical of introduced populations. These results indicated that the diploid/sexually reproducing population from RU-KR was ancestral, located within the centre of the distribution of the species, and the triploid/parthenogenetically reproducing subalpine population was at the margin of the distribution. The current study revealed the allelic structure of the microsatellite loci in the triploid tapeworm for the first time.
Habitat-dependent Culicoides species composition and abundance in blue tit (Cyanistes caeruleus) nests
Authors: Garrido-Bautista Jorge , Martínez-de la Puente Josué , Ros-Santaella José Luis , Pintus Eliana , Lopezosa Paula , Bernardo Nicola , Comas Mar , Moreno-Rueda Gregorio
Published: May 2022

Wild birds are hosts of Culicoides from as early on as the nesting stage when constrained to their nests. However, the environmental factors which determine the abundance and composition of Culicoides species within each bird nest are still understudied. We sampled Culicoides from Eurasian blue tit (Cyanistes caeruleus) nests found in 2 types of forests located in southern Spain. Firstly, we monitored the abundance of Culicoides species in bird nests from a dry Pyrenean oak deciduous forest and a humid mixed forest comprising Pyrenean and Holm oaks throughout 2 consecutive years. During the 3rd year, we performed a cross-fostering experiment between synchronous nests to differentiate the role of rearing environment conditions from that of the genetically determined or maternally transmitted cues released by nestlings from each forest. We found 147 female Culicoides from 5 different species in the birds' nests. The abundance of Culicoides was higher in the dry forest than in the humid forest. Culicoides abundance, species richness and prevalence were greater when the nestlings were hatched later in the season. The same pattern was observed in the cross-fostering experiment, but we did not find evidence that nestling's features determined by the forest of origin had any effect on the Culicoides collected. These results support the notion that habitat type has a strong influence on the Culicoides affecting birds in their nests, while some life history traits of birds, such as the timing of reproduction, also influence Culicoides abundance and species composition.
Language learning and emotion
Authors: Plonsky Luke , Sudina Ekaterina , Teimouri Yasser
Published: May 2022

Language learning can be very emotional, as anyone who has ever tried to learn or use another language (L2) will attest. The range of emotions varies widely in both type and intensity, from the thrill of successfully articulating yourself, for example, to the anxiety of navigating a high-stakes encounter in an L2. It is not surprising, therefore, that there is a longstanding tradition of research on emotion in the context of L2 learning (e.g., Horwitz et al., 1986). In fact, more than 40 years ago, Scovel (1978) reviewed the accumulated evidence on the role of just one emotion: Anxiety.
Disruptive technologies in health care disenchanted: a systematic review of concepts and examples
Authors: Perleth Matthias , Di Bidino Rossella , Huang Li-Ying , Jones Lydia , Mujoomdar Michelle , Myles Susan , Pichon-Riviere Andres , Sabirin Junainah , Schuller Tara , Washington Jennifer
Published: May 2022

Objectives

To clarify the concept of disruptive technologies in health care, provide examples and consider implications of potentially disruptive technologies for health technology assessment (HTA).

Methods

We conducted a systematic review of conceptual and empirical papers on healthcare technologies that are described as “disruptive.” We searched MEDLINE and Embase from 2013 to April 2019 (updated in December 2021). Data extraction was done in duplicate by pairs of reviewers utilizing a data extraction form. A qualitative data analysis was undertaken based on an analytic framework for analysis of the concept and examples. Key arguments and a number of potential predictors of disruptive technologies were derived and implications for HTA organizations were discussed.

Results

Of 4,107 records, 28 were included in the review. Most of the papers included conceptual discussions and business models for disruptive technologies; only few papers presented empirical evidence. The majority of the evidence is related to the US healthcare system. Key arguments for describing a technology as disruptive include improvement of outcomes for patients, improved access to health care, reduction of costs and better affordability, shift in responsibilities between providers, and change in the organization of health care. A number of possible predictors for disruption were identified to distinguish these from “sustaining” innovations.

Conclusions

Since truly disruptive technologies could radically change technology uptake and may modify provision of care patterns or treatment paths, they require a thorough evaluation of the consequences of using these technologies, including economic and organizational impact assessment and careful monitoring.
The epsilon-knowledge: an emerging complement of Machlup's types of disciplinary knowledge
Authors: Horváth Imre
Published: May 2022

Machlup used the words alpha, beta, and gamma to identify humanities, science, and social science as three distinct fields of academic learning and knowing, in addition to general knowledge. Gilles and Paquet identified a fourth type of disciplinary knowledge and labeled it as delta. This includes the knowledge of creative disciplines such as design, law, and economy. Since the time of these road-paving works, a lot has changed. In the last two decades, various concepts and manifestations of intellectualized engineered systems have appeared. A paradigmatic feature of these systems, exemplified by smart cyber-physical systems, is that they collect, infer, or extract massive amount of synthetic system knowledge (M-SSK) based on some pre-programmed human knowledge. The amount of this type of knowledge grows continuously. It can be aggregated on system level and on system of systems level. This paper argues that this aggregated M-SSK is not covered by the abovementioned four genres of knowledge. In fact, it represents a new genre. The conducted literature study underpins this claim. Therefore, the paper suggests dealing with it as a new genre, called epsilon-knowledge. Artificial intelligence, system engineering, cyber-physical systems, and knowledge engineering are the disciplines dealing with epsilon-knowledge. The paper refers to sympérasmology as the proper conceptual framework of studying this genre of knowledge.
The influence of language shift on Sanapaná vowels: An exemplar-based perspective
Authors: Van Gysel Jens E. L.
Published: May 2022

This paper presents the first sociophonetic study of Sanapaná (Enlhet-Enenlhet), spoken by around one thousand people in Paraguay. It examines the effects of L2 (Spanish/Guaraní) fluency and loss of L1 exposure on vowel quality and within-category variability of /e, o/ productions in the Sanapaná /e, a, o/ system. Data from eleven native Sanapaná speakers suggest that age and multilingualism may have little explanatory power by themselves. Speakers living in a majority-L2 environment show greater within-category variability and increased convergence of /e, o/ toward the L2 high vowels /i, u/ than daily users of Sanapaná. This suggests that decreased L1 exposure is the main factor driving language shift-related change in Sanapaná. I explain these findings in an exemplar-theoretic framework. Although the number of speakers sampled is limited, these data provide a valuable addition to our knowledge of sociolinguistic variation in small, underrepresented communities.
Chronic, increasing, and decreasing peer victimization trajectories and the development of externalizing and internalizing problems in middle childhood
Authors: Ettekal Idean , Li Haoran , Chaudhary Anjali , Luo Wen , Brooker Rebecca J.
Published: May 2022

Children’s peer victimization trajectories and their longitudinal associations with externalizing and internalizing problems were investigated from Grades 2 to 5. Secondary data analysis was performed with the Early Childhood Longitudinal Study (ECLS-K-2011; n = 13,860, Mage = 8.1 years old in the spring of Grade 2; 51.1% male, 46.7% White, 13.2% African-American, 25.3% Hispanic or Latino, 8.5% Asian, and 6.1% other or biracial). Children who experienced high and persistent levels of peer victimization (high-chronic victims) exhibited co-occurring externalizing and internalizing problems. Moreover, among high-chronic victims, boys had a more pronounced increase in their externalizing trajectories, and girls had greater increases in their social anxiety trajectories. In contrast, those with decreasing peer victimization across time exhibited signs of recovery, particularly with respect to their social anxiety. These findings elucidated how chronic, increasing, and decreasing victims exhibited distinct patterns in the co-occurring development of their externalizing and internalizing problems, and how findings varied depending on the form of problem behavior and by child sex.
Twitter as Higher-Education Community of Practice: A Political Science Perspective
Authors: Jester Natalie
Published: May 2022

A community of practice is where a group works together toward a shared goal. This article argues that Twitter hosts a community of practice within political science and international relations. This occurs in three key ways: (1) offering an area to share feelings about our role as educators, (2) connecting to a wider network of educators in our discipline (and other disciplines), and (3) providing a space to proffer practical support. This has been especially true during the current COVID-19 pandemic, when many educators are teaching remotely and potentially feeling cut off from colleagues and students at their institution. In more normal times, Twitter also offers a valuable means of connecting with other scholars in the discipline across the world, providing a space to learn from and support one another. The article concludes by reflecting on what this might mean for continued professional development in the political science and international relations discipline.
Undrowned Story: The Landscape on the Volgo–Baltic Waterway as the Volga Hydropower Cascade Submersions Memorial
Authors: Borodulina Alevtina
Published: May 2022

Vast territories along the Volga River basin were intentionally submerged in the 1930s to 1980s for the sake of creating the Volga hydropower cascade. Many people suffered displacement, and hundreds of cultural and historical sites were destroyed or left under water. However, these events were never recognized as a national tragedy in the official public narrative. This article is dedicated to a grassroots project aimed at creating a ‘lieu de mémoire’ for this difficult heritage by preserving the ruins of a submerged church. The ruins marking the transformed landscape bear memories of the events that accompanied that transformation as well as the role of an individual and local community in commemorating the traumatic events. Intentionally preserved ruins are extremely rare for Russia, yet they powerfully link tangible and intangible heritage and give voice to repressed narratives.
The acceptability of cognitive analytic guided self-help in an Improving Access to Psychological Therapies service
Authors: Wray Annie , Kellett Stephen , Bee Charlotte , Smithies Jess , Aadahl Vikki , Simmonds-Buckley Mel , McElhatton Colleen
Published: May 2022

Background:

An Improving Access to Psychological Therapies (IAPT) service in England has implemented cognitive analytic therapy guided self-help (CAT-GSH) alongside cognitive behavioural guided self-help (CBT-GSH) in order to support enhanced patient choice. This study sought to explore the acceptability to psychological wellbeing practitioners (PWPs) of delivering CAT-GSH.

Method:

This study used a qualitative design with semi-structured interviews and associated thematic analysis (TA). A sample ofn=12 PWPs experienced in delivering CAT-GSH were interviewed.

Results:

Five over-arching themes (containing 12 subthemes) were identified and conceptually mapped: (a) the past-present focus (made up of working with clients’ pasts and the different type of change work), (b) expanding the treatment offer (from the perspective of PWPs and clients), (c) the time and resources required to effectively deliver CAT-GSH (to enable safe and effective delivery for clients and personal/professional development for PWPs), (d) understanding CAT-GSH (made up of confidence, learning new therapeutic language/concepts and appreciating the difference with CBT-GSH) and (e) joint exploration (made up of therapeutic/supervisory relationships and enhanced collaboration).

Conclusion:

CAT-GSH appears an acceptable (but challenging) approach for PWPs to deliver in IAPT services. Services should prioritise training and supervision for PWPs to ensure good governance of delivery.
Associations of percentage energy intake from total, animal and plant protein with overweight/obesity and underweight among adults in Addis Ababa, Ethiopia
Authors: Hemler Elena C , Bromage Sabri , Tadesse Amare Worku , Zack Rachel , Berhane Yemane , Canavan Chelsey R , Fawzi Wafaie W , Willett Walter C
Published: May 2022

Objective:

This study investigated associations between types and food sources of protein with overweight/obesity and underweight in Ethiopia.

Design:

We conducted a cross-sectional dietary survey using a non-quantitative FFQ. Linear regression models were used to assess associations between percentage energy intake from total, animal and plant protein and BMI. Logistic regression models were used to examine the associations of percentage energy intake from total, animal and plant protein and specific protein food sources with underweight and overweight/obesity.

Setting:

Addis Ababa, Ethiopia.

Participants:

1624 Ethiopian adults (992 women and 632 men) aged 18–49 years in selected households sampled using multi-stage random sampling from five sub-cities of Addis Ababa.

Results:

Of the surveyed adults, 31 % were overweight or obese. The majority of energy intake was from carbohydrate with only 3 % from animal protein. In multivariable-adjusted linear models, BMI was not associated with percentage energy from total, plant or animal protein. Total and animal protein intake were both associated with lower odds of overweight/obesity (OR per 1 % energy increment of total protein 0·92; 95 % CI: 0·86, 0·99; P = 0·02; OR per 1 % energy increment of animal protein 0·89; 95 % CI: 0·82, 0·96; P = 0·004) when substituted for carbohydrate and adjusted for socio-demographic covariates.

Conclusion:

Increasing proportion of energy intake from total protein or animal protein in place of carbohydrate could be a strategy to address overweight and obesity in Addis Ababa; longitudinal studies are needed to further examine this potential association.
Perceptions of tap water associated with low-income Michigan mothers’ and young children’s beverage intake
Authors: Bauer Katherine W , Weeks Heidi M , Clayson Michelle , Needham Belinda
Published: May 2022

Objective:

To quantify perceptions of tap water among low-income mothers with young children residing in Michigan and examine associations between perceptions of tap water, mothers’ and young children’s beverage intake, and mothers’ infant feeding practices.

Design:

Cross-sectional study.

Setting:

Online survey.

Participants:

Medicaid-insured individuals who had given birth at a large Midwestern US hospital between fall 2016 and fall 2020 were invited by email to complete a survey in winter 2020 (N 3881); 15·6 % (N 606) completed eligibility screening, 550 (90·8 %) were eligible to participate, and 500 (90·9 %) provided valid survey data regarding perceptions of tap water, self and child beverage intake, and infant feeding practices.

Results:

Two-thirds (66·2 %) of mothers reported that their home tap water was safe to drink without a filter, while 21·6 % were unsure about the safety of their home tap water. Mothers’ perceptions of their home tap water were associated with their own tap and bottled water intake and their young children’s tap water and bottled water intake. Mothers with more negative perceptions of tap water in general, independent of their perceptions about their home tap water, consumed more bottled water and sugar-sweetened beverages, and their young children drank bottled water and fruit drinks more frequently. Few associations were observed between mothers’ perceptions of tap water and infant feeding practices.

Conclusions:

Uncertainty about tap water safety and negative perceptions of tap water are common among low-income Michigan mothers. These beliefs may contribute to less healthful and more costly beverage intake among mothers and their young children.
LOG-TRANSFORM AND THE WEAK HARNACK INEQUALITY FOR KINETIC FOKKER-PLANCK EQUATIONS
Authors: Guerand Jessica , Imbert Cyril
Published: May 2022

This article deals with kinetic Fokker–Planck equations with essentially bounded coefficients. A weak Harnack inequality for nonnegative super-solutions is derived by considering their log-transform and adapting an argument due to S. N. Kružkov (1963). Such a result rests on a new weak Poincaré inequality sharing similarities with the one introduced by W. Wang and L. Zhang in a series of works about ultraparabolic equations (2009, 2011, 2017). This functional inequality is combined with a classical covering argument recently adapted by L. Silvestre and the second author (2020) to kinetic equations.
Potential sources of moral distress during COVID-19: Perspectives of hospice interdisciplinary teams
Authors: Jones Tessa , Lin Shih-Yin , Durga Aditi , Luth Elizabeth A. , Lassell Rebecca K.F. , Brody Abraham A.
Published: May 2022

Objective

This study aimed to examine the impact of COVID-19 on hospice Interdisciplinary team (IDT) members’ self-reported stress and identify possible sources of moral distress.

Methods

A cross-sectional survey was conducted using Qualtrics to understand the impact of COVID-19 on quality improvement initiative implementation and hospice IDT members’ general and dementia-specific care provision. Directed qualitative content analysis was used to analyze hospice IDT members’ responses from five open-ended survey questions that were indicative of stress and possible moral distress.

Results

The final sample consisted of 101 unique respondents and 175 comments analyzed. Three categories related to sources of moral distress based on hospice IDT member survey responses were identified: (1) impact of telehealth, personal protective equipment (PPE), and visit restrictions on relationships; (2) lack of COVID-19-specific skills; and (3) organizational climate. Sources of moral distress were categorized in 40% of all responses analyzed.

Significance of results

This study is one of the first to document and confirm evidence of potential stress and moral distress amongst hospice IDT members during COVID-19. It is imperative given the possible negative impact on patient care and clinician well-being, that future research and interventions incorporate mechanisms to support clinicians’ emotional and ethical attunement and support organizations to actively engage in practices that address clinician moral distress resulting from restrictive environments, such as the one necessitated by COVID-19.