bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigation of Water Drainage Capability for Porous Asphalt Material with Varying Slope and Porosity Based on Laboratory Experiment
Authors:   Ho Chi Minh City University of Technology, and Vietnam National University, Le Anh Tuan , Nguyen Quang Truong ,   Ho Chi Minh City University of Technology, and Vietnam National University, Vo Viet Hai ,   Ho Chi Minh City University of Technology, and Vietnam National University, Nguyen Hoang Nam ,   Nam Can Tho University, Cao Phi Long ,   Nam Can Tho University, Chung Van Co ,   Can Tho University of Technology, Nguyen Tan Hung ,   Nam Can Tho University
Published: December 2024

This study assessed the water drainage capability of porous asphalt material (PAM) based on laboratory rainfall simulator tests. A series of tests were conducted using a range of slopes and rainfall intensities. The results showed that as the rainfall intensity increased, the water subsurface drainage steadily decreased. When the slope increased, the subsurface outflow of the porous asphalt decreased. Nevertheless, the slope of PAM insignificantly affected the water subsurface drainage. For the PAM specimen with a porosity of 15%, at a rainfall intensity of 2.5 L/min, when the slope increased from 0% to 8%, the subsurface outflow reduced by 2.8%. The investigation of the effect of porosity on subsurface drainage showed that the porous asphalt with a higher porosity displayed a higher subsurface drainage. At the slope of 4%, at a rainfall intensity of 4.9 L/min, for the PAM specimen with porosity of 10% and 15%, the subsurface outflow was 72.3% and 79.1%, respectively. It could be seen that the porosity had a strong effect on the drainage capability of PAM. The above results imply that the utilization of PAM depended more on the porosity than the slope. In the future, further experiments evaluating the water drainage of PAM should be adopted.
Decoupling of muscle‐tendon unit and fascicle velocity contributes to the in vivo stretch‐shortening cycle effect in the male human triceps surae muscle
Authors: Holzer Denis , Hahn Daniel , Schwirtz Ansgar , Siebert Tobias , Seiberl Wolfgang
Published: December 2024

During the shortening of stretch‐shortening cycles (SSCs), muscle force output is enhanced compared with pure shortening (SHO), referred to as the SSC‐effect. In general, muscle‐tendon unit (MTU), muscle belly, muscle fascicle, and tendon length changes can be decoupled during contraction, which affects force generation and elastic recoil. We researched whether MTU decoupling contributes to the SSC‐effect. Participants performed electrically stimulated submaximal fixed‐end, SSC, and SHO plantar‐flexions on a dynamometer at two velocities (40, 120°/s) and two ranges of motion (15, 25°). Fascicle and tendon length changes of the gastrocnemius medialis, and ankle joint kinematics were assessed by ultrasound and motion capture, respectively. During SSC shortening, ankle joint torque and work, MTU force and work, and fascicle force were increased by 12%–22% compared with SHO, confirming a SSC‐effect. Further, fascicle length change and velocity during SSCs were significantly reduced compared with SHO condition, and SSC fascicle work was decreased by ~35%. Our results indicate that MTU decoupling leads to a reduction in fascicle shortening amplitude and velocity, thereby increasing the muscle's force capacity while reducing its work output during SSC shortening. MTU decoupling therefore contributes to the SSC‐effect and underlines the limited transferability of joint work measurements to estimated muscle work.
Determinants of journalists’ acceptance of using virtual reality (VR) in news production in the Middle East and North Africa (MENA)
Authors: Elareshi Mokhtar , Ziani Abdulkrim , Mesbah Hesham , Alwahaishi Saleh
Published: December 2024

This study identifies and predicts the factors that determine journalists’ acceptance of VR in journalism and news production, and their intention to adopt this technology in the Middle East and North Africa (MENA). A total of 787 online survey responses were analyzed. On a theoretical level, Technology Acceptance Model (TAM) constructs were used to identify the independent variables and develop the research hypotheses. The study found that perceived efficiency of VR is related to the perceived ease of use and perceived usefulness of VR in journalism. Respondents’ behavioral intentions to accept and adopt VR in journalism are contingent upon how these journalists perceive VR as an innovative way to reach audiences and engage them. The paper contributes to our understanding of respondents’ behavioral intentions to accept and adopt VR in journalism. Those intensions are contingent upon how these journalists perceive VR as an innovative way to reach audiences and engage them, including how various media outlets around the world are using VR.
Parallel transport on non-collapsed 𝖱𝖢𝖣(𝐾, 𝑁) spaces
Authors: Caputo Emanuele , Gigli Nicola , Pasqualetto Enrico
Published: December 2024

We provide a general theory for parallel transport on non-collapsed

RCD

\mathsf{RCD}

spaces obtaining both existence and uniqueness results.
Our theory covers the case of geodesics and, more generally, of curves obtained via the flow of sufficiently regular time dependent vector fields: the price that we pay for this generality is that we cannot study parallel transport along a single such curve, but only along almost all of these (in a sense related to the notions of Sobolev vector calculus and regular Lagrangian flow in the non-smooth setting).
The class of

ncRCD

\mathsf{ncRCD}

spaces contains finite-dimensional Alexandrov spaces with curvature bounded from below; thus our construction provides a way of speaking about parallel transport in this latter setting alternative to the one proposed by Petrunin in [Parallel transportation for Alexandrov space with curvature bounded below, Geom. Funct. Anal.
8 (1998), 1, 123–148].
The precise relation between the two approaches is yet to be understood.
Menstrual Cycle Phase–Based Strength & Conditioning Training for Elite Team Sport Female Athletes
Authors: Moore Sam R. , Bruinvels Georgie , Smith-Ryan Abbie E.
Published: December 2024

Despite continued success, female athletes are still underresourced and minoritized in research and applied spaces. This has translated to disparate injury and health outcomes among female athletes resulting from a sport infrastructure built on male physiology. The purpose of this article is to propose an evidence- and experience-based menstrual cycle (MC) phase–based training model for practitioners working with elite female athletes in team sport. Here, we provide physiological rationale, privacy considerations, and best practices to support female-centric training. The following model proposes periodization based on a theorized capacity of adaptation rather than acute performance or symptomology alone because evidence suggests that performance changes across the MC may be highly individual. In addition, strength and conditioning programs are formulated to balance stressors and recovery in the pursuit of optimal adaptation, irrelevant of acute exercise performance. Finally, we identify future directions for applied practitioners and researchers, and the potential need for collaborative innovations between the communities. Creating a training model based on the physiology and experience of female athletes communicates to female athletes that they belong in sport and are worthy of our time, attention, and resources to improve their health, safety, and performance now and through active retirement.
MONTAGEM E ESTRANHAMENTO
Authors: Stefânia Zim Aline
Published: December 2024

As expressões do cinema poético, cinema puro ou do cinema intelectual dos anos 1920 trouxeram o discurso antirrealista da descontinuidade visual como a nova linguagem. Contra a ideia de representação e mimese da realidade do cinema narrativo, as vanguardas provocavam a estranheza no espectador. O acesso à obra não era imediato: era mediado pela teoria e pela conceituação. O problema central da montagem no cinema foi a busca desse “novo realismo”, cuja estética estava apoiada na essência fílmica, na linguagem poética ou num idealismo evidente, seja ele formalista, no caso das vanguardas francesas, seja social, quando se trata do cine-discurso soviético. Tomando o princípio formalista de que a linguagem precisa se renovar através da arte, configurou-se nos anos 1920 uma estética de vanguarda, em contraposição ao cinema naturalista, que primava pelas técnicas da imitação e do ilusionismo.
UM OUTRO ETHOS DO MORAR
Authors: Guatelli Igor , Fabiano Junior Antonio , F. Queiroga Eugenio , Freitas Fuão Fernando , Freitas Lemos José Carlos , Sollero Lemos Isabela , De Mello Franco Fernando , T. Wisnik Guilherme , Pessoa Luciano
Published: December 2024

Em tempos de alargamento do exercício da soberania, da intensificação da vigilância e do aprimoramento das técnicas de geo-localização populacionais, esse artigo multifacetado, aqui apresentado em uma forma polifônica de pequenos ensaios críticos quase independentes, originou-se de uma pesquisa sobre os processos do morar advindos de imprevisíveis deslocamentos e deslocalizações locais de indivíduos e grupos. Um morar resultado de ações intrusivas em lugares interditados, mas não só. Ocupações assumem aqui traços constituintes de um morar que se constrói a partir de uma hospitalidade quase incondicional, uma morada que se oferece como lugar privado de moradores, mas também como construção coletiva de seminais sociabilidades em seus pequenos espaços gestacionais intramuros. Pequenas cosmopolíticas interiores.
ALDEIA URBANA ÁGUA BONITA EM CAMPO GRANDE/MS
Authors: Albuquerque Palhares Machado Flávia Cristina , Dalpério Cuissi Isadora , De Campos Maciel Josemar
Published: December 2024

Este trabalho tem por objetivo investigar e analisar a forma de habitar de comunidades indígenas urbanas, conhecidas como Aldeias Urbanas e compreender como habitam o espaço diante das transformações urbanas de Campo Grande MS, com foco na Aldeia Urbana Água Bonita. A pesquisa tem abordagem qualitativa e a metodologia abrange pesquisa bibliográfica e coleta de informações por meio de visitas e diálogo colaborativo com os membros da comunidade. Os resultados evidenciam que a apropriação do espaço urbano pelos indígenas é mediada pelos valores culturais, espirituais e históricos originais destes povos e modo de habitar indígena transcende a ocupação física do espaço e inclui a vida social e comunitária e também a organização política para a reivindicação dos seus direitos.
ALÉM DO DESERTO
Authors: Silva Freire Ana Luiza , Bohmer Britto Marcos
Published: December 2024

Há muito nosso modo de pensar esteve centrado na figura humana como principal agente das transformações da paisagem do planeta. Se apoiando na oposição dicotômica cultura e natureza, este pensamento se insere num contexto mais amplo: a era geológica nomeada de Antropoceno. A emergência climática consequente ao Antropoceno suscita previsões de que o planeta não suportará mais o modo de vida posto atualmente pelo Ocidente capitalista, o que recai sobre uma equivalência entre a extinção da vida humana e a extinção da vida, em geral, e das múltiplas existências na Terra. Como objeto de pensamento, este artigo utiliza-se de uma concha, encontrada durante um processo de pesquisa empírico, e tomada como artefato arqueológico. O debate conceitual segue o rastro desse caco do tempo presente, bem como se baseia na materialidade e nas histórias das paisagens onde a concha foi encontrada, e se fundamenta nas noções de Deserto, de Elisabeth Povinelli (2023), e Paisagens relacionais, de Anna Tsing (2019). Objetiva-se, dessa maneira, discutir ontologicamente possibilidades de paisagens pós-antropocêntricas complexas, para além da dualidade natureza/cultura.
Liberdade de expressão a partir da tradição liberal: principais contribuições segundo Benjamin Constant e John Stuart Mill
Authors: Souza Martins Leandro José
Published: December 2024

Este texto, mediante revisão bibliográfica, procura apresentar algumas reflexões sobre a liberdade de expressão e regulamentação estatal a partir da leitura de autores da tradição liberal. Especificamente, resgata as lições de Benjamin Constant e de John Stuart Mill sobre a prioridade da liberdade de expressão ante qualquer restrição ou regulamentação do Estado, excetuando as circunstâncias extremamente necessárias para tal regulação. A leitura dos autores liberais ajuda a entender, no tempo presente, quais seriam as implicações, potencialidades e limites da liberdade de expressão, bem como evidencia como é tênue a linha que discerne se a intervenção do Estado nas liberdades individuais ocorre como uma garantia de ampla participação ou como uma ação totalitária e controladora que visa defender vieses específicos, que seriam, em síntese, atentatórios ao próprio direito de liberdade de expressão.
Application of the Christiansen Dividing-wall Column Configuration for Multicomponent System Separation
Authors: Lukač Goran , Bilmez Ivan , Dejanović Igor
Published: December 2024

Dividing wall distillation columns (DWC) represent a significant advancement in the process industry, promoting sustainability and reducing overall CO2 emissions in continuous separation processes. Currently, DWC applications are mostly limited to three-product configurations, with a single known commercial implementation for four products in the so-called Kaibel configuration, which uses a single vertical dividing wall. While this simplified structure offers advantages in terms of implementation, its structural limitations lead to a reduced degrees of freedom for process control. This limitation is particularly evident in the main fractionator, where the central section between the two side products must operate in total reflux mode. Maintaining this mode in practice can be challenging, especially during process disturbances, often resulting in degraded quality of the two side products.To address this operational issue, a novel configuration is proposed, featuring a horizontal partition between the two side products, and a heat exchanger to maintain thermal coupling between the newly formed sections of the main fractionator. This configuration, referred to as the “|- column” in the literature, was first introduced by Atle C. Christiansen. It effectively eliminates remixing of the middle components, and allows for additional introduction or removal of thermal energy, enabling both sections of the prefractionator to operate near their optimal conditions. Theoretically, this enables more flexible column operation and decoupling of the two sections.In this work, steady-state simulation results of both column configurations are compared using detailed distillation models. A multicomponent hydrocarbon mixture containing 15 components is used as a separation example, with separation into four products.
Management of Innovative Changes of the "Smart Enterprise" in the Conditions of Business Scaling and Industry 4.0
Authors:   National Technical University, Pererva Petro ,   Kharkiv Polytechnic Institute, Kobielieva Tetiana ,   National Technical University "Kharkiv Polytechnic Institute", Dolyna Iryna ,   National Technical University "Kharkiv Polytechnic Institute"
Published: December 2024

The article explores the theoretical and practical aspects of managing innovative changes in "smart enterprises" in the context of
business scaling and the impact of Industry 4.0. The main challenges faced by enterprises in integrating modern digital technologies
such as the Internet of Things, artificial intelligence, automation, and big data analytics are outlined. The key components of
innovation management have been identified: strategic, organizational, technological and cultural. Approaches to the
implementation of digital solutions to increase the efficiency of operations, optimize resources and ensure the flexibility of the
enterprise are considered. Mechanisms for overcoming resistance to changes among personnel and recommendations for the
formation of an innovation-oriented corporate culture are described. Practical recommendations for managing innovative changes
are proposed, allowing enterprises to remain competitive, ensure stable development and effective scaling of business in the
conditions of Industry 4.0.
Comparative analysis of PI3K-AKT and MEK-ERK1/2 signaling-driven molecular changes in granulosa cells
Authors: Baddela Vijay Simha , Michaelis Marten , Tao Xuelian , Koczan Dirk , Brenmoehl Julia , Vanselow Jens
Published: December 2024

In brief

PI3K-AKT signaling activates steroidogenesis by inducing estradiol and progesterone production, while MEK-ERK1/2 signaling regulates steroidogenesis by inhibiting estradiol and inducing progesterone production in granulosa cells (GCs). Both pathways are essential for glycolytic and mitochondrial metabolism in these cells.

The PI3K-AKT and MEK-ERK1/2 signaling pathways are integral to fundamental cellular processes, such as proliferation, viability and differentiation. In GCs, these pathways are activated by follicle-stimulating hormone (FSH) and IGF1 through respective receptors. We investigated the comparative transcriptome changes induced by the AKT and ERK (ERK1/2) pathways using corresponding inhibitors in GCs. GCs isolated from antral follicles showed positive signals for phospho-AKT and phospho-ERK proteins. Treatment of cultured GCs with FSH and IGF1 induced phospho-AKT and phospho-ERK levels. Transcriptome analysis revealed 1436 genes regulated by AKT and 654 genes regulated by the ERK pathway. Among these, 94 genes were commonly downregulated and 11 genes were commonly upregulated in both datasets, while 110 genes were oppositely regulated. Bioinformatics analysis revealed that the inhibition of the PI3K-AKT and MEK-ERK pathways downregulates key reproductive processes and upstream molecules. Notably, AKT inhibition affected FSH, ESRRG and HIF1 pathways, while ERK inhibition impacted CG, FOS, TGFβ, EGR1 and LH pathways. Transcriptome data showed that genes related to estradiol production were inhibited by ERK and induced by the AKT pathway. This was verified by radioimmunoassays, and mRNA and protein analysis of CYP19A1 and STAR genes. In addition, transcriptome data suggested the downregulation of glucose metabolism in GCs. Using validation experiments, we confirm that both pathways are essential for glucose uptake, lactate production and mitochondrial activity in GCs. These data provide a resource for informing future research for analyzing various novel candidate genes regulated by the AKT and ERK pathways in GCs and other cell types.
Studies of composite reservoir rocks from shallow lying horizons of the Pryluky uplift of the Dnieper-Donets depression
Authors: Kurovets Ihor , Zubko Oleksandr , Hrytsyk Ihor , Chepusenko Pavlo , Prykhodko Oleksandr , Melnychuk Svitlana , Kucher Zoryana
Published: December 2024

Increase in the production and stepping up the rate of hydrocarbon reserves is an important task for keeping Ukraine supplied with its own resources. Development of the missed upper horizons or those that are considered to be non-commercial is the cheapest way to increase production. Shallow lying horizons C-8 and C-9 of the Serpukhovian deposits of the Pryluky uplift belong to such objects. Unconventional reservoirs composed of layered, lithologically uneven layers of composite structure of porous space and considerable changeability of the composition are considered to be perspective. Relatively low natural radio-activity according to data of gamma-ray logging, the absence of spontaneous potential-anomalies, somewhat low values of specific resistance, insignificant increase in indices of potential sounding in comparison with gradient sounding, increased values of residual saturation factor are characteristic indications of these reservoir rocks.
According to data of geophysical well logging, the reliable ways and methods of predicting qualitative and quantitative characteristics of the main petrophysical parameters of the reservoirs of given type are absent up to the present because petrophysical properties of such reservoirs are studied not fully. Their development requires the execution of experimental complex investigations of the core samples selected from these horizons that allows us to study the interconnections and mutual stipulating of collecting and geophysical properties of reservoirs with controlled change in parameters in the course of the experiments and to determine the complex of informative parameters of the well logging.
As a result of conducted studies of the rock samples, the lithological type of reservoir was determined and its lithological-petrophysical characteristic was given. Matrix of the rock contains porous space of different type and genesis. Porosity of the interlayers of sandy aleurolites, that are the main oil-saturated reservoirs, reaches the value of 23 to 28 per cent, and with the aid of fractures along bedding of all another lithological varieties, including clayish, they are connected into a single hydrodynamic system bifurcated in the rocks with decreased solidity, and therefore very sensitive to stress redistribution and formation pressure.
There correlational ties between geophysical and capacity-filtration parameters of the reservoir rocks were determined, petrophysical models were constructed for normal and formational conditions and the main factors, sufficiently influencing their value, were determined.
Use of chemometric methods and regression models in processing NIR spectra of peat for quantitative determination of its chemical and technological indicators
Authors: Khokha Yurii , Yakovenko Myroslava
Published: December 2024

The article discusses theoretical and practical aspects of the use of near infrared (NIR) spectroscopy combined with chemometrics for express analysis of peat. Near infrared spectroscopy provides a significant amount of information about complex organic systems, including irregular polymers such as peat. Compared to classical analytical methods, NIR spectrometry allows analysis without complex sample preparation with analysis time measured in minutes. Since the results represent the intensity of radiation reflection in the overtone range of fundamental frequencies, their processing requires the use of special mathematical and statistical methods. The use of the Chemoface software package modules (PLS method) for quantitative analysis of the technical and chemical properties of peat based on NIR spectroscopy data has demonstrated the possibility of obtaining calibration models that allow for the quick and reliable analysis of this raw material, including in field conditions. The conducted studies have shown that using a spectrometer that analyzes reflected (absorbed) radiation in the near-infrared spectrum and based on the averaged spectral characteristics of the reflected (absorbed) radiation and using chemometric software, it is possible to calculate the chemical and technological characteristics of peat. The analysis procedure consists of the following stages: selection of a sample representing the entire batch of raw materials; irradiation of the sample with radiation containing a significant proportion of energy in the near-infrared spectrum; analysis with a detector of reflected (absorbed) radiation and construction of an integral spectral characteristic of the sample; compilation of a calibration model using chemometric software; processing of the obtained spectrum using chemometric software with subsequent calculation of the qualitative and quantitative characteristics of the raw materials. The proposed method (express analysis) for rapid determination of qualitative and quantitative characteristics of fossil carbon raw materials of organic origin, namely lowland and highland peat of various degrees of decomposition, can be used to establish its compliance with current norms, standards and technical conditions for moisture content, ash (inorganic) residue content and acidity (pH).
HIF-2α level in adolescents with chronic inflammatory pathology of the upper gastrointestinal tract
Authors:   V. N. Karazin Kharkiv National University, Kharkiv, Ukraine, Shevchenko, N. S. ,   State Institution “Institute for Children and Adolescents Health Care at the National Academy of Medical Sciences of Ukraine”, Kharkiv, Ukraine;, Krutenko, N. V. ,   V. N. Karazin Kharkiv National University, Kharkiv, Ukraine;, Sukhova, L. L. ,   State Institution “Institute for Children and Adolescents Health Care at the National Academy of Medical Sciences of Ukraine”, Kharkiv, Ukraine;, Tsiura, O. M. ,   V. N. Karazin Kharkiv National University, Kharkiv, Ukraine;, Shlienkova, H. O. ,   V. N. Karazin Kharkiv National University, Kharkiv, Ukraine;, Voloshyn K. V. ,   V. N. Karazin Kharkiv National University, Kharkiv, Ukraine;
Published: December 2024

Сhronic inflammatory diseases of the gastrointestinal tract are among the most common pathological conditions in adolescents. A significant role in the pathogenesis of gastrointestinal tract diseases is given to the functioning of the oxygen sensor system, the main mediator of which is hypoxia-inducible factor 2 (HIF-2α). Therefore, the purpose of the study was to determine the level of HIF-2α in the plasma of patients with chronic inflammatory pathology of the gastrointestinal tract, taking into account the endoscopic picture of the lesion, localization of the pathological process, age and gender of the patient. The study involved 70 adolescents aged 8-18 years with chronic gastroduodenitis (CGD), gastroesophageal reflux disease (GERD), gastric or duodenal ulcer and 25 peers who had been classified as healthy. The plasma concentration of HIF-2α was measured by a sandwich-linked ELISA. Helicobacter pylori infection was determined by urease test or by ELISA. According to the data obtained, the HIF-2α plasma level was higher in patients with chronic inflammatory gastrointestinal disease compared to the control group. In boys with chronic gastroduodenal disease, the level of HIF-2α was higher than in girls. CGD and GERD were characterized by a higher HIF-2α level in plasma than gastric and duodenal ulcers. The HIF-2α level did not depend on the age of the patients or the presence of Helicobacter pylori infection.

Keywords: adolescents, chronic gastroduodenitis, gastroesophageal reflux disease, gastrointestinal tract, HIF-2α
C(60) fullerene effect on the functional activity of rat gastrocnemius muscle during its regeneration after the open injury
Authors:   ESC “Institute of Biology and Medicine”, Taras Shevchenko National University of Kyiv, Ukraine, Nozdrenko, D. M. , Gonchar, O. O. ,   Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv;, Nurishchenko, N. E. ,   ESC “Institute of Biology and Medicine”, Taras Shevchenko National University of Kyiv, Ukraine;, Stetska, V. O. ,   ESC “Institute of Biology and Medicine”, Taras Shevchenko National University of Kyiv, Ukraine;, Matviienko, T. Yu. ,   ESC “Institute of Biology and Medicine”, Taras Shevchenko National University of Kyiv, Ukraine;, Stepanyuk, Ya. V. ,   Medical Faculty, Lesya Ukrainka Volyn National University, Lutsk, Ukraine;, Bogutska, K. I. ,   ESC “Institute of Biology and Medicine”, Taras Shevchenko National University of Kyiv, Ukraine;, Prylutskyy Yu. I. ,   ESC “Institute of Biology and Medicine”, Taras Shevchenko National University of Kyiv, Ukraine;
Published: December 2024

Open injuries are one of the most common skeletal muscle traumas. The study aimed to estimate the effect of the oral administration of C60 fullerene aqueous solution (C60FAS) daily at a dose of 1 mg/kg on the restoration of rat skeletal muscle functional activity on the 5th, 10th and 15th day after the open trauma. Male Wistar rats were randomly divided into three groups of 12 animals in each: control, with muscle injury and with muscle injury+C60FAS. The isolated gastrocnemius muscle was subjected to open injury by transverse dissection with a depth of 1 mm. Stimulation of muscle efferents was carried out by electrical impulses gene­rated using a strain gauge generator. The content of C-reactive protein, creatinine, lactate, reduced glutathione and the activity of catalase and superoxide dismutase in the rat blood were determined. According to the data obtained, application of C60FAS promotes the restoration of the functional activity of injured muscle, which was confirmed by a significant increase in gastrocnemius muscle force impulse, attenuation of the inflammatory and development of fatigue and normalization of pro- and antioxidant balance in the process of regeneration.

Keywords: C60 fullerene, gastrocnemius muscle, lactate, muscle force impulse, open injury, pro-antioxidant balance, protein C
“Oxford housewife” or the only british woman to have ever won the Nobel Prize in science? – Dorothy Hodgkin
Authors:   Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, Danilova, V. M. , Torkhova, S. G. ,   Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;, Komisarenko S. V. ,   Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;
Published: December 2024

Dorothy Crowfoot Hodgkin, a British chemist and Nobel Prize winner, who extended the method of X-ray crystallography to determine the structure of biomolecules that furthered the development of structural biology. In 1964, she was awarded the Nobel Prize in Chemistry “for the determinations by X-ray techniques of the structures of important biochemical substances”, particularly vitamin B12 and antibiotic penicillin. Five years after winning the Nobel Prize, Dorothy Hodgkin also established the structure of insulin. Although The Daily Mail headlined her as an “Oxford housewife”, Dorothy Hodgkin overcame gender inequality to become the third woman in history to win the Nobel Prize in Chemistry and remains the only British woman researcher to be awarded the most prestigious prize in the sciences.

Keywords: Dorothy Hodgkin, insulin, Nobel Prize in Chemistry, structures of penicillin, vitamin B12, X-ray crystallography
Development of eco-friendly UPLC methods for metformin and empagliflozin by combining green chemistry with analytical quality by design
Authors: Vijayamma Gummalla , Nirmala S.
Published: December 2024

The need to develop environmentally friendly analytical approaches has driven the pharmaceutical industry to seek greener alternatives. Ultra-Performance Liquid Chromatography (UPLC) is known for its efficiency but traditionally relies on toxic solvents. Integrating Green Analytical Chemistry (GAC) principles aims to address environmental concerns while maintaining analytical performance. This work aims to advance and authenticate a green, efficient UPLC method for the concurrent quantification of Metformin (MET) and Empagliflozin (EPI) in tablet formulations, adhering to green chemistry principles and ensuring high analytical accuracy. The method was optimized using a UPLC-PDA system with a phenyl column and a mobile phase of ethanol and perchloric acid. Analytical Quality by Design (AQbD) was employed to optimize critical method parameters. Environmental impact was assessed using metrics such as GAPI, AMGS, and AGREE. Degradation studies under various stress conditions were performed to test method robustness. The method achieved high recovery rates for MET and EPI, with minimal interference from excipients. The environmental evaluation showed a high Analytical Eco-Score (AES) of 97, indicating low environmental impact. The AGREE score of 0.89 confirmed excellent alignment with green chemistry principles. Degradation studies confirmed the method's stability and reliability under stress conditions. The developed UPLC method demonstrates a significant advancement in analytical sustainability, offering an eco-friendly, efficient, and precise approach to drug analysis. The method's high alignment with green chemistry principles and its effectiveness in quantifying MET and EPI highlight its potential as a model for sustainable analytical practices in pharmaceutical analysis.
Konwencjonalizm francuski a "konwencjonalizm" K. R. Poppera
Authors: Załuski Wojciech
Published: December 2024

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Tajemnica Cantora
Authors: Piechowicz Robert
Published: December 2024

Recenzja publikacji:
Amir D. Aczel, Tajemnica alefów. Matematyka, kabała i poszukiwanie nieskończoności, Nowe Horyzonty, Rebis, Poznań 2002, ss. 207.
O Karla R. Poppera skłonnościowej interpretacji prawdopodobieństwa
Authors: Załuski Wojciech
Published: December 2024

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Rozwój nauki a filozofia nowej muzyki
Authors: Brożek Anna
Published: December 2024

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Sympozjum "Nauka w poszukiwaniu filozofii"
Authors: Schoen-Żmijowa Aleksandra
Published: December 2024

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Problems of formation of managerial personnel in the Russian Federation
Authors: Leskova Irina
Published: December 2024

The new socio-political challenges faced by the state require a change in the nature of the formation of managerial personnel. The author of the article draws attention to the nature of socio-economic relations, which serve as the basis for a qualitative assessment of the existing system of formation of the administrative apparatus in state and municipal institutions. Special emphasis is placed on the lack of stable systemic foundations in the selection and placement of managerial personnel. Based on solid empirical material, previously conducted research on the identification of negative personality traits of managers, the author builds his own idea of how its formation should be carried out. For both general and particular issues of the socio-political existence of our country depend on how managerial personnel are formed. The modern interaction between the managerial and subordinate stratum of employees (the subordinate and in many ways even the disenfranchised position of the latter) allows individual authors to consider it as a traditional phenomenon for our state. The article shows that this kind of statement has a pronounced provocative character, which does not always have a real historical basis. In particular, the author attempts to compare the principles of the formation of the administrative apparatus in state bodies and in the penitentiary community. Having considered the points of view available in the literature on this subject, the author comes to the conclusion that both management systems are based on completely different (diametrically opposed) principles. The main criterion here is their effectiveness, where achieving the desired result should be guaranteed by a system of high-quality selection of managerial personnel. As a conclusion, the author makes the assumption that only a change in the nature of the selection and placement of managerial personnel can serve as a guarantee of stable and high-quality work of the administrative apparatus in the state.
Consolidation of social forces is the key national security
Authors: Mchedlova Elena
Published: December 2024

The article analyzes the issues of interrelation and interdependence of the sociocultural situation and political reality; consolidation, ensuring social security, human rights and freedoms, national security — based on humanitarian, cultural, spiritual, moral, religious and other values — against the background of transformational socio-cultural, political and ideological processes taking place in the country.
The article contains a rationale for one of the consolidating ideas that dominate Russian society and are in constant evolution — human rights, which also perform an integrative function, orienting peoples and entire states towards mutual assistance and cooperation. Particular emphasis is placed on the principle of solidarity, which is understood as a kind of value of a collectivist nature, meaning spiritual unity, support, mutual assistance and joint actions, based on mutual trust, recognition of rights, duties and responsibilities. It is noted that solidarity, moreover, manifests itself in the system of human rights in a dual sense — legal and moral. Currently, this principle is quite widely used in government strategy, in particular, in the concept of sustainable development.
Social forces that in many ways consolidate peoples, as well as acting as a kind of guardians of traditional values (these today are: moral ideals, the priority of the spiritual over the material, a strong family, social service, peace and unity) are almost all existing faiths. The discussion provides examples of the integration worldviews of some of them, showing how today's church is involved in social processes aimed at ensuring social consensus and security.
As a result, it is noted that, despite recent political events, value aspects remain one of the main regulators accompanying the formation of Russian national, civil and cultural identity, contributing to an increased sense of patriotism, spiritual unity and mutual cultural enrichment; they also act as a kind of cultural basis for the current concept of national sovereignty and national security.
Specificity of «Anna Karenina»: political images of the main characters of the novel
Authors: Vasil'chenko Tat'yana
Published: December 2024

The article examines the political images and social archetypes of the main characters of the novel: Anna Arkadyevna Karenina and Alexei Alexandrovich Karenin. Based on the characteristics of the characters, the author attempted to reconstruct the political reality of Russia in the 1870s (this is the time when the novel takes place) and compare it with modern reality. The analysis of the characters of the work is considered as a procedure for identifying the main factors that determine the logic of the actions of the main characters of the novel, by studying the political processes and phenomena of the 19th century from the standpoint of symbolism.
In his work, Leo Tolstoy raises problems of a socio-philosophical nature that are relevant to this day, and in a modern interpretation they are reflected in the field of cinema and theater arts, in which political meanings can also be captured.
The purpose of the study is aimed at identifying the key political aspects of the novel, based on which it is possible to assess the degree of politicization of the work. To achieve the stated goal, the following tasks were formulated: to analyze the theoretical base, which presents expert opinions of literary scholars, historians and political scientists on the issues under study; to study the autograph (manuscript) of the novel and get acquainted with the original intentions of the narrator; to consider the images of the characters in the context of comparative analysis and from the point of view of political science; to identify the criteria for comparing the «political environment» of society in the 19th and 21st centuries. Drawing conclusions and summarizing the above, the author comes to the conclusion that the political component is certainly present in the novel and manifests itself in the interaction of the main characters, and is also an epiphenomenon of the work.
PRÁCTICAS DE EVALUACIÓN FORMATIVA EN EDUCACIÓN: TENDENCIAS EN LATINOAMÉRICA Y EL MUNDO
Authors: Tapia Ramos Gloria Isabel , Santa María Relaiza Héctor Raúl
Published: December 2024

La evaluación formativa se ha convertido en un aspecto crucial a nivel educativo en todo el mundo. La situación latinoamericana y de otros países muestra las deficiencias en esta área de la práctica docente, así como en su correcta implementación como respaldo a las estrategias empleadas. En consecuencia, se hizo necesario realizar una revisión de la literatura con el objetivo de identificar las tendencias en la aplicación de la evaluación formativa en instituciones públicas. Para ello fue ejecutada una revisión sistemática apoyada en la metodología PRISMA, que arrojó 24 documentos vinculados al tema, localizados en la base de datos de Scopus publicados entre 2019 y 2023 y que cumplieron con los criterios de inclusión establecidos. Los resultados evidenciaron la importancia de las prácticas de la evaluación formativa para el estudiante. La revisión realizada mostró, en la totalidad de los documentos, el papel tan significativo que actualmente está tomando en Latinoamérica y el mundo la evaluación formativa en los diferentes sistemas educativos; sin embargo, aún existe dificultad y resistencia en su implementación debido al desconocimiento y a los modelos de aprendizaje tradicionales utilizados.
The mechanical responses of railway tracks through shear forces
Authors: Fonseca da Gama Marina , de Aragão Filho Luiz A. C. M. , do Nascimento Filipe A. C. , Junqueira João F. A.
Published: December 2024

Owing to increases in axle load, operational density, authorized speed and train size, continuous evaluations of railway track, which consider dynamic loads, have become increasingly crucial to ensure the efficiency and safety of railways. In this article, a theoretical and experimental analysis of the mechanical behaviour of a railway track was developed. A numerical model was formulated treating the rail as a continuous elastically supported beam, following the Winkler foundation concept. By applying concentrated vertical loads and varying the stiffness of the supports, the shear forces on the beam were determined for different scenarios. Experimentally, a strain gauge was installed on the rail of a Brazilian railway, and shear strain data were collected from multiple passes of loaded wagons at different speeds and directions. A numerical procedure was proposed to standardize the experimental data and compare them with the results previously deduced from a simplified superstructure model. The theoretical and experimental results largely agreed, and the dimensionless parameters obtained from the experimental results were related to those obtained by the numerical model, finally estimating the value of the track modulus.
Macrophage-Derived Type 1 IFN, Renal Tubular Epithelial Cell Polyploidization, and AKI-to-CKD Transition
Authors: Wang Yaqin , Lan Qigang , Li Fugang , Xiong Jiachuan , Xie Hailun , Gong Shuiqin , Yao Mengying , Lv Liangjing , Qin Shaozong , Xin Wang , Zhang Aihong , Zhou Siyan , Huang Yinghui , Zhao Jinghong
Published: December 2024

Key Points

Macrophage-derived IFN-β contributes to tubular epithelial cell polyploidization after AKI.

IFN-β induced tubular epithelial cell polyploidization by regulating inorganic pyrophosphatase-mediated yes-associated protein (YAP) dephosphorylation.

Delayed blockade of the IFN-β response attenuated persistent polyploidization and kidney fibrosis.

Background

AKI is recognized as a common risk factor of CKD. Renal tubular epithelial cell polyploidization after AKI is closely associated with maladaptive repair, while the regulatory and molecular mechanisms remain poorly understood. In this study, we set out to investigate the mechanism of tubular epithelial cell polyploidization and their role in AKI-to-CKD transition.

Methods

The change characters of polyploid tubular epithelial cells and macrophages after AKI were detected by flow cytometry and immunofluorescence. The underlying mechanism was explored by RNA-sequencing analysis, immunofluorescence, and Western blot. The role of tubular epithelial cell polyploidization in AKI-to-CKD transition was evaluated by transgenic mice and drug interventions.

Results

We discovered that tubular epithelial cells underwent polyploidization after AKI, and polyploid tubular epithelial cells exhibited greater fibrotic phenotypes than nonpolyploid cells. Furthermore, we revealed an upregulated IFN-β response feature within tubular epithelial cells after AKI and identified that macrophage-derived IFN-β bound to IFN-I receptor 1 of tubular epithelial cells and induced their polyploidization. Mechanistically, IFN-β, secreted by macrophages through activation of the cyclic guanosine monophosphate-AMP synthase-stimulator of IFN genes pathway, acted on tubular epithelial cells and facilitated inorganic pyrophosphatase binding to yes-associated protein (YAP), which mediated YAP dephosphorylation and subsequent nuclear translocation, culminating in p21 expression and polyploidization. Importantly, delayed blockade of the IFN-β response and pharmacological inhibition of stimulator of IFN genes or YAP activation on day 4 after AKI significantly attenuated persistent tubular epithelial cell polyploidization and AKI-induced kidney fibrosis.

Conclusions

Macrophage-derived IFN-β contributed to tubular epithelial cell polyploidization by regulating inorganic pyrophosphatase/YAP signaling pathway–mediated p21 expression and further promoted AKI-to-CKD transition.
İNSAN SERMAYESİ YAKLAŞIMININ KURAMSAL ELEŞTİRİSİ VE AMARTYA SEN VE MASLOW’UN ÖĞRETİLERİ IŞIĞINDA YENİ BİR SOSYAL VE EKONOMİK KALKINMA MODELİ
Authors: Kapçak Cemal Bilge
Published: December 2024

Bu çalışma, para kazanmaya ve başarılı olmaya endeksli bir yaşamın eleştirisidir. Aynı zamanda İnsan Sermayesi Yaklaşım’ında ihmal edilen insanın psikolojik boyutuna vurgu yapılarak, Sen ve Maslow’un teorileri ışığında yeni bir sosyal ve ekonomik kalkınma modeli ortaya konulmaya çalışılmıştır. Sen’in Kalkınma Yaklaşımı, Maslow’un İhtiyaçlar Hiyerarşisi Teorisi’nin devamı niteliğinde bütüncül bir biçimde ele alınarak incelenmiştir. Kendini gerçekleştirme olgusu Maslow’a göre bir bitiş noktası iken, Sen’e göre bir başlangıçtır. Bu perspektiften ele alınan bu çalışma gerek bireysel gelişim gerekse toplumsal kalkınma bağlamında kollektif bir iş birliği aracılığıyla rasyonel uygulamaları gerektirmektedir. Dolayısıyla uygulamaların yeniden üretimine önayak olabilecek, farkındalığı yüksek politika üreticilerine ve örgüt yöneticilerine büyük iş düşmektedir. Toplumdaki her bir ferdin potansiyelini açığa çıkarmaya dönük ortaya konan uygulamaların toplumsal iş birliği içerisinde başarıya ulaşması ve bunun sürdürülebilirliğinin sağlanması, ortak değer ve davranış haline dönüşmesi bireyi de toplumu da dönüştürecektir. Türkiye özelinde modelin uygulanabilirliği güç olsa da düşünsel anlamda ortaya konulması bile önemli görülmektedir. “Aydın insan” yetiştirebilmenin kilit bir rol oynadığı modelde, sınav kaygısının giderilmesi ve öğrenmenin hazza dönüştürülebilmesi iki kritik noktayı oluşturmaktadır.
Gefährdung durch Gewaltereignisse beurteilen, aber wie?
Authors:   Berufsgenossenschaft für Gesundheitsdienst und Wohlfahrtspflege (BGW), Hamburg, Ostendorf Pamela , Ludwig-Hartmann Julia ,   Freie Dozentin, Beraterin, Coachin, Fachkraft für Arbeitssicherheit, Runkel
Published: December 2024

Assessing the risk of violence, but how? – Addressing violence and aggression in the risk assessment
Incidents of violence are not uncommon in many health and welfare facilities. What is rarer, however, is the systematic and analytical handling of these incidents of violence. But how do you get there? And what role do company physicians play in this? A risk assessment that addresses the issue of violence is a central component of successful violence prevention management. It can significantly improve the internal handling of incidents of violence and thus also contribute to a reduction in incidents of violence. In this article, two methodological approaches to the risk assessment of violence are presented.
Plantas medicinales. Sendero de la Laguna de Cuicocha
Authors:   Universidad Politécnica Salesiana, Ecuador, Noriega Rivera Paco Fernando
Published: December 2024

El Ecuador cuenta con una asombrosa variedad de espacios naturales de ensueño, como la laguna volcánica de Cuicocha, visitada cada año por cientos de miles de personas de diversas nacionalidades. Recorrer el sendero que rodea la laguna nos permite apreciar paisajes únicos. Además de su belleza, el trayecto alberga una rica biodiversidad animal y vegetal. En este catálogo se presentan cincuenta plantas útiles para los seres humanos que se encuentran a lo largo de doce kilómetros del sendero. Este hecho destaca aún más la importancia que tiene la preservación y cuidado de nuestros parques y reservas naturales.