bluuebunny/crossref_metadata_2025 huggingface dataset:
Chia Phenolic Extract Appear to Improve Small Intestinal Functionality, Morphology, Bacterial Populations, and Inflammation Biomarkers In Vivo (Gallus gallus)
Authors: Mishima Marcella , Martino Hércia , Kolba Nikolai , Agarwal Nikita , Jackson Cydney , da Silva Bárbara , Grancieri Mariana , de Assis Andressa , São José Vinícius , Tako Elad
Published: August 2023

Phenolic compounds can act as a substrate for colonic resident microbiota. Once the metabolites are absorbed and distributed throughout the body, they can have diverse effects on the gut. The objective of this study was to evaluate the effects of the intra-amniotic administration of a chia phenolic extract on intestinal inflammation, intestinal barrier, brush border membrane functionality, intestinal microbiota, and morphology in vivo (Gallus gallus model). Cornish-cross fertile broiler eggs, at 17 days of embryonic incubation, were separated into groups as follows: non-injected (NI; this group did not receive an injection); 18 MΩ H2O (H2O; injected with ultrapure water), and 10 mg/mL (1%) chia phenolic extract (CPE; injected with phenolic extract diluted in ultrapure water). Immediately after hatch (21 days), chickens were euthanized and their small intestine, cecum, and cecum content were collected and analyzed. The chia phenolic extract reduced the tumor necrosis factor-alpha (TNF-α) and increased the sucrose isomaltase (SI) gene expression, reduced the Bifidobacterium and E. coli populations, reduced the Paneth cell diameter, increased depth crypt, and maintained villus height compared to the non-injected control group. Chia phenolic extract may be a promising beneficial compound for improving intestinal health, demonstrating positive changes in intestinal inflammation, functionality, microbiota, and morphology.
Differences in Nutrient Intake and Diet Quality among Non-Hispanic Black Adults by Place of Birth and Length of Time in the United States
Authors: Adeyemi-Benson Oluwafikayo S. , Roehll Alexandra M. , Flores Edson , Singleton Chelsea R.
Published: August 2023

Prior research suggests that migrating to the United States (US) can negatively affect the diets and health of immigrants. There is limited information on how relocating to the US affects the diets of Black-identifying immigrants. To address this gap, this study examined differences in nutrient intake and diet quality among non-Hispanic Black adults by place of birth and length of time in the US. Cross-sectional data from the National Health and Nutrition Examination Survey (2005–2016) were analyzed. Approximately 6508 non-Hispanic Black adults were categorized into three groups: foreign-born (FB) living in the US <10 years (n = 167), FB living in the US ≥ 10 years (n = 493), and US-born (n = 5848). Multivariable-adjusted logistic and linear regression models were evaluated to identify differences in nutrient intake and diet quality (as measured by the Healthy Eating Index (HEI) of 2015) across the three groups when controlling for socio-demographics. Compared to US-born adults, both FB groups had significantly higher HEI-2015 scores and higher odds of meeting dietary recommendations for several nutrients: saturated fat, sodium, and cholesterol. There were no differences in nutrient intake between the two FB groups; however, FB (<10 years) adults had better diet quality than FB (≥10 years) ones. Place of birth and length of time in the US were associated with dietary intake among non-Hispanic Black adults. More research is needed to improve understanding of dietary acculturation among Black-identifying immigrants in the US.
Hepatocyte Aquaporins AQP8 and AQP9 Are Engaged in the Hepatic Lipid and Glucose Metabolism Modulating the Inflammatory and Redox State in Milk-Supplemented Rats
Authors: Trinchese Giovanna , Gena Patrizia , Cimmino Fabiano , Cavaliere Gina , Fogliano Chiara , Garra Sabino , Catapano Angela , Petrella Lidia , Di Chio Silvia , Avallone Bice , Calamita Giuseppe , Mollica Maria Pina
Published: August 2023

Milk is an important source of nutrients and energy, but there are still many uncertainties regarding the health effects of milk and dairy products consumption. Milk from different species varies in physicochemical and nutritional properties. We previously showed that dietary supplements with different milks in rats trigger significant differences in metabolic and inflammatory states, modulating mitochondrial functions in metabolically active organs such as the liver and skeletal muscle. Here, we have deepened the effects of isoenergetic supplementation of milk (82 kJ) from cow (CM), donkey (DM) or human (HM) on hepatic metabolism to understand the interlink between mitochondrial metabolic flexibility, lipid storage and redox state and to highlight the possible role of two hepatocyte aquaporins (AQPs) of metabolic relevance, AQP8 and AQP9, in this crosstalk. Compared with rats with no milk supplementation, DM- and HM-fed rats had reduced hepatic lipid content with enhanced mitochondrial function and decreased oxidative stress. A marked reduction in AQP8, a hydrogen peroxide channel, was seen in the liver mitochondria of DM-fed rats compared with HM-fed, CM-fed and control animals. DM-fed or HM-fed rats also showed reduced hepatic inflammatory markers and less collagen and Kupffer cells. CM-fed rats showed higher hepatic fat content and increased AQP9 and glycerol permeability. A role of liver AQP8 and AQP9 is suggested in the different metabolic profiles resulting from milk supplementation.
Low Levels of Serum and Intracellular Vitamin C in Hospitalized COVID-19 Patients
Authors: Boerenkamp Lara S. , Gijsbers Birgit L. M. G. , Ververs Erik-Jan , Pijpers Eva M. S. , Spaetgens Bart , de Coninck Aniek , Germeraad Wilfred T. V. , Wodzig Will K. W. H. , Wieten Lotte , van Gorkom Gwendolyn N. Y. , van Elssen Catharina H. M. J.
Published: August 2023

Vitamin C is a crucial micronutrient for human immune cell function and has potent antioxidant properties. It is hypothesized that vitamin C serum levels decline during infection. However, the precise mechanisms remain unknown. To gain deeper insights into the true role of vitamin C during infections, we aimed to evaluate the body’s vitamin C storage during a SARS-CoV-2 infection. In this single-center study, we examined serum and intracellular vitamin C levels in peripheral blood mononuclear cells (PBMCs) of 70 hospitalized COVID-19 patients on the first and fifth days of hospitalization. Also, clinical COVID-19 severity was evaluated at these timepoints. Our findings revealed a high prevalence of hypovitaminosis C and vitamin C deficiency in hospitalized COVID-19 patients (36% and 15%). Moreover, patients with severe or critical disease exhibited a higher prevalence of low serum vitamin C levels than those with moderate illness. Serum vitamin C levels had a weak negative correlation with clinical COVID-19 severity classification on the day of hospitalization; however, there was no correlation with intracellular vitamin C. Intracellular vitamin C levels were decreased in this cohort as compared to a healthy cohort and showed further decline during hospitalization, while serum levels showed no relevant change. Based on this observation, it can be suggested that the reduction of intracellular vitamin C may be attributed to its antioxidative function, the need for replenishing serum levels, or enhanced turnover by immune cells. These data give an incentive to further investigate the role of intracellular vitamin C in a larger and more heterogeneous cohort as well as the underlying mechanisms.
Modified Mediterranean-Ketogenic Diet and Carboxytherapy as Personalized Therapeutic Strategies in Lipedema: A Pilot Study
Authors: Di Renzo Laura , Gualtieri Paola , Zomparelli Samanta , De Santis Gemma Lou , Seraceno Silvia , Zuena Claudia , Frank Giulia , Cianci Rossella , Centofanti Domenico , De Lorenzo Antonino
Published: August 2023

In recent years, the use of the ketogenic diet as a proper nutritional treatment for lipedema has been hypothesized in the literature. This is the first clinical study evaluating the ketogenic diet and carboxytherapy in lipedema patients. In the present study, it was decided to use a modified Mediterranean ketogenic diet (MMKD) in combination with carboxytherapy. Since lipedema is characterized by microangiopathy, local hypoxia, and increased subcutaneous adipose tissue (SAT) deposition, carboxytherapy could improve painful symptoms and skin tone. A total of 22 subjects were included in the data analysis, divided into three groups; 8 patients underwent MMKD combined with carboxytherapy sessions (KDCB group), 8 underwent MMKD nutritional treatment alone (KD group), and 6 patients underwent only carboxytherapy sessions (CB group), for a total of 10 weeks of treatment for all three groups. It was observed that the ketogenic diet effectively induced weight and fat mass loss, including in the limbs, areas considered unresponsive to diet therapy in lipedema patients. However, the best results were obtained from the combination of the ketogenic diet and carboxytherapy, which showed improvements in both body composition and skin texture and a reduction in pain, along with an improvement in sleep quality. It would be helpful to conduct a clinical trial on a larger scale and over a more extended period to observe the results in the long term as well.
Gender Disparities in Osteoporosis Knowledge, Health Beliefs and Preventive Behaviors in Najran City, Saudi Arabia
Authors: Ibrahim Heba A. , Nahari Mohammed H. , Al-khadher Mugahed A. , Ismail Nemat I. , Elgzar Wafaa T.
Published: August 2023

Osteoporosis is a chronic bone disease affecting both men and women, but it is more prevalent in women. Promoting a healthy lifestyle among adults, particularly women, is crucial in preventing and reducing the osteoporosis impact. This study aimed to compare the osteoporosis knowledge, health beliefs and preventive behaviors among adult male and female in Najran city Saudi Arabia. This cross-sectional study was performed on 516 males and 581 females in Najran City, Saudi Arabia, from January to April 2023. The data collection instrument is a self-reported online questionnaire consisting of basic data, the Osteoporosis Preventive Behavior (OPB) scale, the osteoporosis knowledge assessment tool, and the osteoporosis health belief scale. The results revealed that male participants had a higher OPB (26.70) than females (20.32). However, females have a higher knowledge (10.71), perceive themselves as more susceptible to osteoporosis (20.34) and had higher exercise barriers (20.11) compared to males (9.97, 18.79 and 19.20, respectively). Statistically significant correlations (p < 0.001) were observed between OPB, osteoporosis knowledge (r = 0.26), perceived susceptibility (r = 0.33), severity (r = 0.53), exercise (r = 0.54) and calcium (r = 0.33) benefits, exercise (r = 0.40) and calcium (r = 0.81) barriers and health motivation (r = 0.37). The study concluded significant disparities between males and females regarding osteoporosis-related knowledge, preventive behaviors, perceived susceptibility, severity, and exercise perceived barriers. The results suggest gender-based educational interventions to enhance OPB by addressing osteoporosis-related knowledge, perceived susceptibility, seriousness, benefits, and health motivation.
Quercetin Alleviated Inflammasome-Mediated Pyroptosis and Modulated the mTOR/P70S6/P6/eIF4E/4EBP1 Pathway in Ischemic Stroke
Authors: Alattar Abdullah , Alshaman Reem , Althobaiti Yusuf S. , Soliman Ghareb M. , Ali Howaida S. , Khubrni Waleed Salman , Koh Phil Ok , Rehman Najeeb Ur , Shah Fawad Ali
Published: August 2023

Stroke ranks as the world’s second most prevalent cause of mortality, and it represents a major public health concern with profound economic and social implications. In the present study, we elucidated the neuroprotective role of quercetin on NLRP3-associated pyroptosis, Nrf2-coupled anti-inflammatory, and mTOR-dependent downstream pathways. Male Sprague Dawley rats were subjected to 72 h of transient middle cerebral artery ischemia, followed by the administration of 10 mg/kg of quercetin. Our findings demonstrated that MCAO induced elevated ROS which were coupled to inflammasome-mediated pyroptosis and altered mTOR-related signaling proteins. We performed ELISA, immunohistochemistry, and Western blotting to unveil the underlying role of the Nrf2/HO-1 and PDK/AKT/mTOR pathways in the ischemic cortex and striatum. Our results showed that quercetin post-treatment activated the Nrf2/HO-1 cascade, reversed pyroptosis, and modulated the autophagy-related pathway PDK/AKT/mTOR/P70S6/P6/eIF4E/4EBP1. Further, quercetin enhances the sequestering effect of 14-3-3 and reversed the decrease in interaction between p-Bad and 14-3-3 and p-FKHR and 14-3-3. Our findings showed that quercetin exerts its protective benefits and rescues neuronal damage by several mechanisms, and it might be a viable neuroprotective drug for ischemic stroke therapy.
ED Formula, a Complex of Ecklonia cava and Chrysanthemum indicum, Ameliorates Airway Inflammation in Lipopolysaccharide-Stimulated RAW Macrophages and Ovalbumin-Induced Asthma Mouse Model
Authors: Kang Hyun , Park Chan-Hwi , Kwon Sang-Oh , Lee Sung-Gyu
Published: August 2023

Ecklonia cava (E. cava) and Chrysanthemum indicum Linne (C. indicum) are natural raw materials known to have beneficial effects on inflammatory-related diseases, as evidenced by various sources in the literature. This study aimed to investigate the airway-protective effects of a formulation called ED, comprising E. cava and C. indicum, by evaluating its potential anti-inflammatory properties. Methods: The major components of ED were analyzed using high-performance liquid chromatography (HPLC) and its anti-inflammatory activity was assessed in RAW 264.7 cells through measurements of nitric oxide’s (NO) inhibitory effect, cyclooxygenase (COX)-2 protein expression, and the mitogen-activated protein kinase (MAPK) signaling pathway. Additionally, the anti-inflammatory effect of ED was evaluated in an ovalbumin-induced asthma model by measuring cytokine levels in serum, bronchoalveolar lavage fluid (BALF), and lung tissue. Through HPLC analysis, the major components of ED, dieckol and luteolin, were identified. ED demonstrated no cytotoxicity and effectively reduced NO production in lipopolysaccharide (LPS)-induced RAW 264.7 cells. Moreover, ED downregulated COX-2 expression through the MAPK signaling pathway in LPS-induced RAW 264.7 cells. In the ovalbumin-induced asthma model, the ED-treated group exhibited reduced levels of inflammatory cytokines in lung tissue. Furthermore, the ED-treated group showed a decrease in the number of inflammatory cells in BALF and lower serum interleukin (IL)-6 levels compared to the ovalbumin-treated group. These results suggest that ED has the potential to be a novel therapeutic agent for improving inflammatory respiratory diseases.
Concurrent Imaging and Clinical Study of the Efficacy of Hyaluronic Acid Injection for Knee Osteoarthritis: A Synovial Membrane Investigation with Ultrasound Imaging
Authors: Wang Chien-Chih , Hu Tsung-Ming , Chen Chien-Lung , Hong Chung-Chih , Chang Yu-Hui , Kao Chung-Lan
Published: August 2023

We investigated whether hyaluronic acid (HA) injections can ameliorate ultrasound-detected synovitis in knee osteoarthritis (OA). We recruited 103 patients with symptomatic knee OA and ultrasound-detected synovitis and performed two ultrasound-guided fluid drainage procedures, followed by the administration of a low-molecular-weight HA injection (2.5 mL) in the subpatellar bursa, at a 2-week interval. Knee ultrasound imaging evaluations were performed before injection (baseline) and at 1 and 6 months after the second injection and included the measurements of synovial vascularity by using color Doppler ultrasound, synovial fluid depth over the suprapatellar bursa (SF), and synovial hypertrophy (SH). Initial clinical assessments included a visual analog scale (VAS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). VAS scores decreased significantly at both 1-month and 6-month evaluations (p < 0.001). WOMAC scores also significantly decreased at 1 month (p < 0.001), but not at 6 months (p = 0.23). The ultrasound parameters did not significantly change, except color Doppler grading, which tended to decrease at the 6-month evaluation (p = 0.059). Our findings revealed that two ultrasound-guided HA injections following fluid drainage improved pain and knee function but did not considerably influence imaging-detected synovitis in patients with knee OA.
Modulating the Effect of β-Sitosterol Conjugated with Magnetic Nanocarriers to Inhibit EGFR and Met Receptor Cross Talk
Authors: Ilangovan Shanmuga Sundari , Mahanty Biswanath , Perumal Venkatesan , Sen Shampa
Published: August 2023

The cross-talk between the EGFR (Epidermal Growth Factor Receptor) and MET (Hepatocyte Growth Factor Receptor) poses a significant challenge in the field of molecular signaling. Their intricate interplay leads to dysregulation and contributes to cancer progression and therapeutic resistance. β-Sitosterol (BS), a plant sterol with promising anticancer properties, shows increased research on its potential as a chemopreventive agent. However, significant modifications are required to deliver BS in cancer cells due to its lower efficacy. The present work aims to design a carrier-mediated delivery system specifically targeting cancer cells with EGFR and MET receptor cross-talk. Surface modification of BS was performed with superparamagnetic iron oxide nanoparticles (SPIONs), polyethylene glycol (PEG), and poly(N-isopropylacrylamide) (PNIPAM) to enhance the delivery of BS at the target site. BS was conjugated with SPIONs (BS-S), PNIPAM (BS-SP), PEG, and PNIPAM (BS-SPP) polymers, respectively, and the conjugated complexes were characterized. Results showed an increase in size, stability, and monodispersity in the following order, BS-S, BS-SP, and BS-SPP. The drug encapsulation efficiency was observed to be highest in BS-SPP (82.5%), compared to BS-S (61%) and BS-SP (74.9%). Sustained drug release was achieved in both BS-SP (82.6%) and BS-SPP (83%). The IC 50 value of BS, BS-S, BS-SP, and BS-SPP towards MCF 7 was 242 µg/mL,197 µg/mL, 168 µg/mL, and 149 µg/mL, HEPG2 was 274 µg/mL, 261 µg/mL, 233 µg/mL and 207 µg/mL and NCIH 460 was 191 µg/mL, 185 µg/mL, 175 and 164 µg/mL, indicating highest inhibition towards NCIH 460 cells. Our results conclude that β-sitosterol conjugated with SPION, PEG, and PNIPAM could be a potential targeted therapy in inhibiting EGFR and MET receptor-expressing cancer cells.
Effect of Switching to Once-Weekly Semaglutide on Non-Alcoholic Fatty Liver Disease: The SWITCH-SEMA 1 Subanalysis
Authors: Nomoto Hiroshi , Takahashi Yuka , Takano Yoshinari , Yokoyama Hiroki , Tsuchida Kazuhisa , Nagai So , Miya Aika , Kameda Hiraku , Cho Kyu Yong , Nakamura Akinobu , Atsumi Tatsuya
Published: August 2023

Non-alcoholic fatty liver disease (NAFLD) is an important common comorbidity in individuals with type 2 diabetes (T2DM). Although some glucagon-like peptide-1 receptor agonists (GLP-1RAs) have beneficial effects on NAFLD, the efficacy of once-weekly semaglutide has not been established. This was a subanalysis of the SWITCH-SEMA 1 study, a multicenter, prospective, randomized, parallel-group trial comparing switching from liraglutide or dulaglutide to once-weekly semaglutide in subjects with T2DM (SWITCH) versus continuing current GLP-1RAs (Continue) for 24 weeks. This subanalysis consisted of participants who were suspected to have NAFLD [fatty liver index (FLI) ≥ 30]. In total, 58 participants met the criteria of this subanalysis. There were no statistical differences in baseline characteristics between the SWITCH (n = 31) and Continue groups (n = 27). FLI significantly improved during treatment in the SWITCH group (68.6 to 62.7) but not in the Continue group (71.1 to 72.3) (p < 0.01). The improvement of FLI in the SWITCH group was greater in switching from dulaglutide to semaglutide and significantly correlated with older age (p = 0.016) and lower baseline FLI (p < 0.01). The multiple linear regression analysis revealed that the switch from dulaglutide was associated with an improvement in FLI (p = 0.041). Switching from conventional GLP-1RAs to once-weekly semaglutide might be beneficial for individuals with NAFLD complicated with T2DM.
Advance and Challenges in the Treatment of Skin Diseases with the Transdermal Drug Delivery System
Authors: Cheng Tingting , Tai Zongguang , Shen Min , Li Ying , Yu Junxia , Wang Jiandong , Zhu Quangang , Chen Zhongjian
Published: August 2023

Skin diseases are among the most prevalent non-fatal conditions worldwide. The transdermal drug delivery system (TDDS) has emerged as a promising approach for treating skin diseases, owing to its numerous advantages such as high bioavailability, low systemic toxicity, and improved patient compliance. However, the effectiveness of the TDDS is hindered by several factors, including the barrier properties of the stratum corneum, the nature of the drug and carrier, and delivery conditions. In this paper, we provide an overview of the development of the TDDS from first-generation to fourth-generation systems, highlighting the characteristics of each carrier in terms of mechanism composition, penetration method, mechanism of action, and recent preclinical studies. We further investigated the significant challenges encountered in the development of the TDDS and the crucial significance of clinical trials.
Rapid Prototyping Technologies: 3D Printing Applied in Medicine
Authors: Oleksy Małgorzata , Dynarowicz Klaudia , Aebisher David
Published: August 2023

Three-dimensional printing technology has been used for more than three decades in many industries, including the automotive and aerospace industries. So far, the use of this technology in medicine has been limited only to 3D printing of anatomical models for educational and training purposes, which is due to the insufficient functional properties of the materials used in the process. Only recent advances in the development of innovative materials have resulted in the flourishing of the use of 3D printing in medicine and pharmacy. Currently, additive manufacturing technology is widely used in clinical fields. Rapid development can be observed in the design of implants and prostheses, the creation of biomedical models tailored to the needs of the patient and the bioprinting of tissues and living scaffolds for regenerative medicine. The purpose of this review is to characterize the most popular 3D printing techniques.
An Insight on the Possible Association between Inflammatory Bowel Disease and Biologic Therapy with IL-17 Inhibitors in Psoriasis Patients
Authors: Orzan Olguța Anca , Țieranu Cristian George , Olteanu Andrei Ovidiu , Dorobanțu Alexandra Maria , Cojocaru Anca , Mihai Mara Mădălina , Popa Liliana Gabriela , Gheorghiu Ana Maria , Giurcăneanu Călin , Ion Ana
Published: August 2023

Psoriasis is a chronic, inflammatory, multisystemic disease which affects approximately 2–3% of the population globally, whose onset is triggered by genetic and environmental factors which activate both dendritic cells and keratinocytes, resulting in the production of proinflammatory cytokines such as tumor necrosis factor alpha, interleukin 17, interleukin 23, interleukin 22, and interleukin 1β. An in-depth understanding of the pathophysiology of psoriasis led to significant advances in the development of safe and efficient novel therapeutic options, with four classes of biologic therapy being approved for the management of moderate to severe psoriasis: tumor necrosis factor alpha inhibitors, interleukin 23 inhibitors, anti-interleukin 12/23 agents, anti-interleukin 17 agents, as well as small-molecule inhibitors, such as apremilast. Psoriasis is associated with comorbid conditions, namely psoriatic arthritis, cardiovascular disease, metabolic syndrome, psychiatric disorders, malignancy, as well as inflammatory bowel disease. For patients affected by both psoriasis and inflammatory bowel disease, there is a strong recommendation to avoid IL-17 inhibitors since they may play a part in the exacerbation of the gastrointestinal disease. Our aim was to perform a thorough literature review regarding the development of inflammatory bowel disease lesions in psoriasis patients treated with IL-17 inhibitors, along with a case presentation to emphasize the need for close follow-up of these patients.
An Ytterbium-Doped Narrow-Bandwidth Randomly Distributed Feedback Laser Emitting at a Wavelength of 976 nm
Authors: Davydov Danila A. , Rybaltovsky Andrey A. , Aleshkina Svetlana S. , Velmiskin Vladimir V. , Likhachev Mikhail E. , Popov Sergei M. , Ryakhovskiy Dmitry V. , Chamorovskiy Yuriy K. , Umnikov Andrey A. , Lipatov Denis S.
Published: August 2023

All-fiber, polarization maintaining, narrow-bandwidth, Yb-doped fiber lasers with randomly distributed feedback operated near 976 nm were realized for the first time. It was shown that the laser operated in a single, longitudinal mode regime during intervals of a few seconds. At other times, the laser generated a few longitudinal modes, but its bandwidth was always below the resolution of the optical spectrum analyzer (0.02 nm). The linewidth of each single longitudinal mode of the laser was estimated to be below 20 kHz. The reasons for this observed laser behavior were discussed and methods for achieving stable, continuous wave operation in the single-longitudinal-mode regime were proposed.
Benzothiazole Derivatives of Chitosan and Their Derived Nanoparticles: Synthesis and In Vitro and In Vivo Antibacterial Effects
Authors: Shakola Tatsiana V. , Rubanik Vasili V. , Rubanik Vasili V. , Kurliuk Aleh V. , Kirichuk Anatoly A. , Tskhovrebov Alexander G. , Egorov Anton R. , Kritchenkov Andreii S.
Published: August 2023

In this work, we focused on synthesizing and assessing novel chitosan-based antibacterial polymers and their nanoparticles by incorporating benzothiazole substituents. The growing resistance to antibiotics has necessitated the search for alternative antimicrobial compounds. This study aimed to synthesize and evaluate chitosan-based polymers and nanoparticles with benzothiazole substituents for their antibacterial properties and toxicity. The benzothiazole derivatives of chitosan and their nanoparticles were synthesized through electrochemical coupling. The in vivo antibacterial efficacy was tested on white rats with induced peritonitis using a microbial suspension containing S. aureus and E. coli. Additionally, in vitro and in vivo toxicity assessments were conducted. The chitosan-based antibacterial systems showed significant in vivo antibacterial activity, surpassing that of unmodified chitosan and commercial antibiotics. Moreover, the toxicity studies revealed low toxicity levels of the synthesized derivatives, which did not differ significantly from native chitosan. The synthesized chitosan-based polymers and nanoparticles demonstrated potent antibacterial activity and low toxicity, highlighting their potential as effective alternatives to traditional antibiotics. Further investigations in pharmacology and preclinical trials are recommended to explore their application in clinical settings.
High-Performance Reversible Furan–Maleimide Resins Based on Furfuryl Glycidyl Ether and Bismaleimides
Authors: Wang Jiawen , Li Jixian , Zhang Jun , Liu Shuyue , Wan Liqiang , Liu Zuozhen , Huang Farong
Published: August 2023

Two reversible furan–maleimide resins, in which there are rigid -Ph-CH2-Ph- structures and flexible -(CH2)6- structures in bismaleimides, were synthesized from furfuryl glycidyl ethers (FGE), 4,4′-diaminodiphenyl ether (ODA), N,N’-4,4′-diphenylmethane-bismaleimide (DBMI), and N,N′-hexamethylene-bismaleimide (HBMI). The structures of the resins were confirmed using Fourier transform infrared analysis, and the thermoreversibility was evidenced using differential scanning calorimetry (DSC) analysis, as well as the sol-gel transformation process. Mechanical properties and recyclability of the resins were preliminarily evaluated using the flexural test. The results show the Diels–Alder (DA) reaction occurs at about 90 °C and the reversible DA reaction occurs at 130–140 °C for the furan–maleimide resin. Thermally reversible furan–maleimide resins have high mechanical properties. The flexural strength of cured FGE-ODA-HBMI resin arrives at 141 MPa. The resins have a repair efficiency of over 75%. After being hot-pressed three times, two resins display flexural strength higher than 80 MPa.
Suitability of MRF Recovered Post-Consumer Polypropylene Applications in Extrusion Blow Molded Bottle Food Packaging
Authors: Ignacio Ma. Cristine Concepcion D. , Tumu Khairun N. , Munshi Mita , Vorst Keith L. , Curtzwiler Greg W.
Published: August 2023

Polypropylene (PP) is one of the most abundant plastics used due to its low price, moldability, temperature and chemical resistance, and outstanding mechanical properties. Consequently, waste from plastic materials is anticipated to rapidly increase with continually increasing demand. When addressing the global problem of solid waste generation, post-consumer recycled materials are encouraged for use in new consumer and industrial products. As a result, the demand is projected to grow in the next several years. In this study, material recovery facility (MRF)-recovered post-consumer PP was utilized to determine its suitability for extrusion blow molded bottle food packaging. PP was sorted and removed from mixed-polymer MRF-recovered bales, ground, trommel-washed, then washed following the Association of Plastics Recyclers’ protocols. The washed PCR-PP flake was pelletized then manually blended with virgin PP resin at 25%, 50%, 75, and 100% PCR-PP concentrations and fed into the extrusion blow molding (EBM) machine. The EBM bottles were then tested for physical performance and regulatory compliance (limits of TPCH: 100 μg/g). The results showed an increased crystallization temperature but no practical difference in crystallinity as a function of PCR-PP concentrations. Barrier properties (oxygen and water vapor) remained relatively constant except for 100% MRF-recovered PCR-PP, which was higher for both gas types. Stiffness significantly improved in bottles with PCR-PP (p-value < 0.05). In addition, a wider range of N/IAS was detected in PCR-PP due to plastic additives, food additives, and degradation byproducts. Lastly, targeted phthalates did not exceed the limits of TPCH, and trace levels of BPA were detected in the MRF PCR-PP. Furthermore, the study’s results provide critical information on the use of MRF recovered in food packaging applications without compromising performance integrity.
Preparation and Characterization of Activated Carbon/Polymer Composites: A Review
Authors: Yim Yoon-Ji , Kim Byung-Joo
Published: August 2023

Activated carbon (AC) and activated carbon fibers (ACFs) are materials with a large specific surface area and excellent physical adsorption properties due to their rich porous structure, and they are used as electrode materials to improve the performance of adsorbents or capacitors. Recently, multiple studies have confirmed the applicability of AC/polymer compo-sites in various fields by exploiting the unique physical and chemical properties of AC. As the excellent mechanical properties, stability, antistatic and electromagnetic interference (EMI) shielding functions of activated carbon/polymer composite materials were confirmed in recent studies, it is expected that activated carbon can be utilized as an ideal reinforcing material for low-cost polymer composite materials. Therefore, in this review, we would like to describe the fabrication, characterization and applicability of AC/polymer composites.
Hyaluronic Acid. Extraction Methods, Sources and Applications
Authors: Graciela Callejas-Quijada , José Juan Escobar-Chávez , Gieraldin Campos-Lozada , Xóchitl Alejandra Pérez-Marroquín , Gabriel Aguirre-Álvarez
Published: August 2023

In this review, a compilation of articles in databases on the extraction methods and applications of hyaluronic acid (HA) was carried out. HA is a highly hydrated component of different tissues, including connective, epithelial, and neural. It is an anionic, linear glycosaminoglycan (GAG) primarily found in the native extracellular matrix (ECM) of soft connective tissues. Included in the review were studies on the extraction methods (chemical, enzymatical, combined) of HA, describing advantages and disadvantages as well as news methods of extraction. The applications of HA in food are addressed, including oral supplementation, biomaterials, medical research, and pharmaceutical and cosmetic industry applications. Subsequently, we included a section related to the structure and penetration routes of the skin, with emphasis on the benefits of systems for transdermal drug delivery nanocarriers as promoters of percutaneous absorption. Finally, the future trends on the applications of HA were included. This final section contains the effects before, during, and after the application of HA-based products.
The Influence of Physical Properties on the Membrane Morphology Formation during the Nonisothermal Thermally Induced Phase Separation Process
Authors: Ranjbarrad Samira , Chan Philip K.
Published: August 2023

The physical properties of a polymer solution that are composition- and/or temperature-dependent are among the most influential parameters to impact the dynamics and thermodynamics of the phase separation process and, as a result, the morphology formation. In this study, the impact of composition- and temperature-dependent density, heat capacity, and heat conductivity on the membrane structure formation during the thermally induced phase separation process of a high-viscosity polymer solution was investigated via coupling the Cahn–Hilliard equation for phase separation with the Fourier heat transfer equation. The variations of each physical property were also investigated in terms of different boundary conditions and initial solvent volume fractions. It was determined that the physical properties of the polymer solution have a noteworthy impact on the membrane morphology in terms of shorter phase separation time and droplet size. In addition, the influence of enthalpy of demixing in this case is critical because each physical property showed a nonhomogeneous pattern owing to the heat generation during phase separation, which in turn influenced the membrane morphology. Accordingly, it was determined that investigating spinodal decomposition without including heat transfer and the impact of physical properties on the morphology formation would lead to an inadequate understanding of the process, specifically in high-viscosity polymer solutions.
Comparative Study of ZnO-and-TiO2-Nanoparticles-Functionalized Polyvinyl Alcohol/Chitosan Bionanocomposites for Multifunctional Biomedical Applications
Authors: Annu  , Bhat Zafar Iqbal , Imtiyaz Khalid , Rizvi M. Moshahid A. , Ikram Saiqa , Shin Dong Kil
Published: August 2023

This study aimed to synthesize chitosan/polyvinyl alcohol (CS/PVA)-based zinc oxide (ZnO) and titanium dioxide (TiO2) hybrid bionanocomposites (BNCs) and observe their comparative accomplishment against the skin cancer cell line, A431, and antioxidant potential. CS was blended with PVA to form polymeric films reinforced with the immobilization of ZnO and TiO2 nanoparticles (NPs), separately. The optimization of the BNCs was done via physicochemical studies, viz. moisture content, swelling ratio, and contact angle measurements. The free radical scavenging activity was observed for 1,1-diphenyl-2-picryl-hydrazyl, and the antibacterial assay against the Escherichia coli strain showed a higher zone of inhibition. Furthermore, the anticancer activity of the synthesized BNCs was revealed against the skin cancer cell line A431 under varying concentrations of 50, 100, 150, 200, and 300 μg/mL. The anticancer study revealed a high percent of cancerous cell inhibition (70%) in ZnO BNCs as compared to (61%) TiO2 BNCs in a dose-dependent manner.
Potential Application of Yeast Cell Wall Biopolymers as Probiotic Encapsulants
Authors: Utama Gemilang Lara , Oktaviani Lidya , Balia Roostita Lobo , Rialita Tita
Published: August 2023

Biopolymers of yeast cell walls, such as β-glucan, mannoprotein, and chitin, may serve as viable encapsulants for probiotics. Due to its thermal stability, β-glucan is a suitable cryoprotectant for probiotic microorganisms during freeze-drying. Mannoprotein has been shown to increase the adhesion of probiotic microorganisms to intestinal epithelial cells. Typically, chitin is utilized in the form of its derivatives, particularly chitosan, which is derived via deacetylation. Brewery waste has shown potential as a source of β-glucan that can be optimally extracted through thermolysis and sonication to yield up to 14% β-glucan, which can then be processed with protease and spray drying to achieve utmost purity. While laminarinase and sodium deodecyle sulfate were used to isolate and extract mannoproteins and glucanase was used to purify them, hexadecyltrimethylammonium bromide precipitation was used to improve the amount of purified mannoproteins to 7.25 percent. The maximum chitin yield of 2.4% was attained by continuing the acid–alkali reaction procedure, which was then followed by dialysis and lyophilization. Separation and purification of yeast cell wall biopolymers via diethylaminoethyl (DEAE) anion exchange chromatography can be used to increase the purity of β-glucan, whose purity in turn can also be increased using concanavalin-A chromatography based on the glucan/mannan ratio. In the meantime, mannoproteins can be purified via affinity chromatography that can be combined with zymolase treatment. Then, dialysis can be continued to obtain chitin with high purity. β-glucans, mannoproteins, and chitosan-derived yeast cell walls have been shown to promote the survival of probiotic microorganisms in the digestive tract. In addition, the prebiotic activity of β-glucans and mannoproteins can combine with microorganisms to form synbiotics.
Microbeam X-ray Reanalysis on Periodically Assembled Poly(β-Hydroxybutyric acid-Co-β-hydroxyvaleric acid) Tailored with Diluents
Authors: Wu Chun-Ning , Nagarajan Selvaraj , Lee Li-Ting , Su Chean-Cheng , Woo Eamor M.
Published: August 2023

Self-assembly of 3D interiors and iridescence properties of poly(β-hydroxybutyric acid-co-β-hydroxyvaleric acid) (PHBV) periodic crystals are examined using microcopy techniques and microbeam X-ray diffraction. Morphology of PHBV can be tailored by crystallizing in presence of poly(vinyl acetate) (PVAc) or poly(trimethylene adipate) (PTA) for displaying desired periodicity patterns. The regular alternate-layered lamellae of banded PHBV crystal aggregates, resembling the structures the natural mineral moonstone or nacre, are examined to elaborate the origin of light interference and formation mechanisms of periodic lamellar aggregation of PHBV spherulites. By using PHBV as a convenient model and the crystal diffraction data, this continuing work demonstrates unique methodology for effectively studying the periodic assembly in widely varying polymers with similar aggregates. Grating structures in periodically assembled polymer crystals can be tailored for microstructure with orderly periodicity.
C2-Hydrocarbon Mixture Separation on Polyethylene Membranes with Grafted Sulfonated Polystyrene in H+, Li+ and Na+ Forms
Authors: Zhilyaeva Natalya , Sofronov Evgeny , Mironova Elena , Shevlyakova Nina , Tverskoy Vladimir , Stenina Irina , Yaroslavtsev Andrey
Published: August 2023

The olefin separation from their mixture with paraffins by facilitated transport membranes is a very important process for the further macromolecular compounds production. Membranes loaded with silver ions, which are responsible for the facilitated olefin transport, are instable with time due to their reduction, while those containing protons catalyze the polymerization of olefins. In this work, membranes based on polyethylene with grafted sulfonated polystyrene in various ionic forms (H+, Li+, Na+) were used for the first time for the separation of the ethylene/ethane mixture. The influence of sulfonation time, relative humidity, and various ionic forms on ethylene separation was studied. The SEM study shows a non-uniform sulfur distribution over the membrane thickness for membranes sulfonated for different reaction times. With increasing sulfonation time and relative humidity the ethylene permeability and the factor of its separation with ethane increase. Separation factors for membranes in the Li+-form are shown to be as high as for membranes in the H+-form. A possible mechanism for the facilitated ethylene transport is discussed.
Numerical Investigation of the Electro-Thermo Convection in an Inclined Cavity Filled with a Dielectric Fluid
Authors: Akrour Dalila , Elkhazen Mohamed Issam , Hassen Walid , Kriaa Karim , Maatki Chemseddine , Hadrich Bilel , Kolsi Lioua
Published: August 2023

The present work is a numerical analysis of electro-thermo convection, occurring in a square differentially heated cavity filled with a dielectric fluid. The cavity experiences the combined effects of viscous, electrical, and thermal forces. The equations modelling the physical problem are solved via the finite volume approach. The study focuses on the effect of cavity tilt on the fluid flow structure and thermal performance inside the enclosure under the action of an electric field. A parametric study was performed, where the tilt angle is getting varied between 0° and 90°, as well as the Rayleigh number (5000 ≤ Ra ≤ 250,000) and the electric field (0 ≤ T ≤ 800). Furthermore, the electric charge injection level C, the mobility M and the Prandtl Pr numbers were all adjusted to a value of 10. The obtained results demonstrate that the hydrodynamic and thermal fields are significantly impacted by the cavity inclination. In addition, regardless of the thermal Rayleigh’s number, high electric field values could govern fluid movement through electric forces. Electro-convection typically demonstrates an oscillating flow due to the tilting of the cavity which gives rise to a bicellular regime occupying the entire cavity. A correlation has been established to estimate heat transfer by considering various system parameters such as cavity inclination, electrical Rayleigh number, and thermal Rayleigh number.
Study on Sublimation Drying of Carrot and Simulation by Using Cellular Automata
Authors: Shao Jiayuan , Jiao Fan , Nie Lili , Wang Ying , Du Yihan , Liu Zhenyu
Published: August 2023

Vacuum freeze-dried products exhibit properties characteristic of porous media, rendering them superior in both drying and rehydration capabilities. However, the process of sublimation drying is constrained by its substantial time and energy costs. To comprehensively grasp its technological process and identify the optimal process parameters, the cellular automata method was employed for sublimation process simulation. Carrot slices, measuring 10 mm in thickness and 40 mm in radius, were selected for both simulation and experimentation. The sublimation process was characterized using a two-dimensional heat and mass transfer equation, inclusive of a dusty gas model. Additionally, a cellular automaton model was applied to simulate the mass transfer process, temperature, and moisture content changes in the sublimation drying stage. Then, the accuracy of the model was verified through experimentation. There was a remarkable alignment between simulation and experimental outcomes, with determination coefficients R2 of 99.4% for moisture content and 97.6% for temperature variations.
Ibn ‘Arabī and the Theologization of Aristotelian Hylomorphism
Authors: Lala Ismail
Published: August 2023

The works of Aristotle left an indelible impression on Arabic philosophy after the translation movement. While many philosophers accepted the works of the revered First Teacher (Al-Mu‘allim al-awwal), as Aristotle was designated, others sought to reformulate his ideas in accordance with their own priorities. One such thinker is the hugely influential mystical theorist, Muḥyī al-Dīn ibn ‘Arabī (d. 638/1240), who agrees with Aristotle that all existents are hylomorphic compounds made from the combination of form with matter that comes from prime matter, or hyle (hayūlā), which he frequently uses interchangeably with ‘substance’ (jawhar). He claims that prime matter or substance accepts all forms (ṣuwar), but he theologizes these terms as he believes all things are loci of divine manifestation. Ibn ‘Arabī thus situates Aristotelian hylomorphism within the framework of his own metaphysics. He proceeds to equate the universal hayūlā with the primordial ‘cloud’ (‘amā’), mentioned in prophetic traditions, from which all things in the different levels of existence derive because of the existentiating divine breath. When it comes to the sensible world in particular, Ibn ‘Arabī employs the Qur’anic term of ‘dust’ (habā’) to denote prime matter that serves as the basis of sensible hylomorphic compounds. This study conducts close textual content analysis to demonstrate the way in which Ibn ‘Arabī theologizes Aristotelian hylomorphism to expound his conception of the different realms of existence.
From the Human Logos to the Divine Logos: The Anthropological Implications of the Christian Logos-Flesh in Klaus Hemmerle
Authors: Gaudiano Valentina
Published: August 2023

The concept of logos takes on a new and interesting connotation through Christian revelation. The logos—word, discourse, reason—becomes human-divine flesh. Moreover, God, who is Word, needs human words to explain and reveal himself to human beings. In so doing, God lowers himself to the human level, thus becoming manipulable, but at the same time, he makes human words and, consequently, human beings greater and of higher dignity. As a result, the human person becomes the giver of language to the one who allows him to speak. In this paper, I will highlight the consequences of a logos becoming flesh for anthropology, following the line of thought of Klaus Hemmerle. In particular, I will focus on Hemmerle’s trinitarian perspective and his phenomenology of language as a means for explaining Christian revelation.
Effect of Water Vapor Transport on a Typical Rainstorm Process in the Arid Region of Southern Xinjiang: Observations and Numerical Simulations
Authors: Jin Chen , He Qing , Huang Qian
Published: August 2023

There are frequent and intensive periods of heavy rain in the arid areas of southern Xinjiang. This study uses a typical rainstorm process in the South Xinjiang Basin to investigate the weather, physical mechanisms, mesoscale characteristics, and income and expenditure characteristics of water vapor sources, analyzing them using the observation data from southern Xinjiang regional automatic stations, ERA5 reanalysis data, multi-source satellite data, and WRF numerical simulation results. The study results show that torrential rain processes occur in the double-body distribution of the South Asian High in the upper troposphere, which is “high in the east and low in the west,” with “two ridges and one trough” in the middle layer. The development and movement of the low vortex, the configuration of low-level convergence and high-level divergence, and vertical upward movement provide favorable dynamic conditions for heavy rain. Additionally, the Black Sea, the Caspian Sea, the Aral Sea, the Arabian Sea, and the Bay of Bengal are important water vapor sources for this rainstorm. The water vapor reaches the South Xinjiang Basin along westward, southwest, and eastward paths. It is mainly imported into the South Xinjiang Basin from 500 to 300 hPa on the southern border and 700–500 hPa on the west, north, and east borders, and exported from 500 to 300 hPa on the eastern border. The simulation results show that the change in water vapor content significantly influences the precipitation intensity and range. The water vapor transport at the southern boundary contributes the most precipitation during the rainstorm. As the water vapor in the rainstorm area increases (decreases), the ascending motion is strengthened (weakened), the low-level convergence and high-level divergence are strengthened (weakened), the water vapor transport to the middle and high levels increases (decreases), and the precipitation increases (decreases).