bluuebunny/crossref_metadata_2025 huggingface dataset:
Uterine Leiomyoma, Imitating Leiomyosarcoma, of Gigantic Size. Сlinical Observation
Authors:   Russian Medical Academy of Continuous Professional Education, Department of Radiology, Moscow, Russian Federation, Parastaeva L.S. , Khabaeva M.T. ,   Russian Medical Academy of Continuous Professional Education, Department of Radiology, Moscow, Russian Federation, Sheikh Zh.V. ,   Russian Medical Academy of Continuous Professional Education, Department of Radiology, Moscow, Russian Federation,   City Clinical Hospital named after S.P. Botkin, Moscow Healthcare Department, Moscow, Russian Federation,   Burnasyan State Research Center – Federal Medical Biophysical Center of Federal Medical Biological Agency, Tarachkova E.V. ,   Russian Medical Academy of Continuous Professional Education, Department of Radiology, Moscow, Russian Federation, Dunaev A.P. ,   State Budgetary Healthcare Institution “Moscow City Oncological Hospital No. 62 DZ of the City of Moscow”, Moscow region, Russian Federation,   Federal State Budgetary Institution of Additional Professional Education “Central State Medical Academy” of the Office of the President of the Russian Federation, Moscow, Russian Federation
Published: December 2022

Radiation diagnosis of giant uterine fibroids is an urgent problem of modern radiology. Specialists in the field of radiation diagnostics, as a rule, have considerable difficulties in making an accurate diagnosis of a benign tumor of the uterus, taking it for malignant due to its large size. Uterine fibroids are benign tumors of the uterus, which occupies one of the leading places in the structure of diseases of the female reproductive system. A clinical observation of a patient with such a rare pathology as a giant uterine leiomyoma imitating leiomyosarcoma is given, which caused difficulties for radiation diagnosticians in making an accurate diagnosis of uterine fibroids. The use of a complex of histological and immunohistochemical diagnostic methods in combination with radiation imaging methods in difficult cases makes it possible to make the correct diagnosis.
Medullary Sponge Kidney: Clinical and Radiological Manifestations
Authors:   A.I. Burnasyan Federal Medical Biophysical Center, Moscow, Russia, Bikovskiy V.A. , Ionova E.A. ,   A.I. Burnasyan Federal Medical Biophysical Center, Moscow, Russia, Anosova T.A. ,   A.I. Burnasyan Federal Medical Biophysical Center, Moscow, Russia
Published: December 2022

The aim of the investigation was to present the results of dynamic ultrasound examination of the evolution of local changes accompanying kidney injury in comparison with the studied manifestations of pathomorphogenesis of renal injury. Dynamic ultrasound examination of 216 patients aged 2 to 16 years with kidney injury of varying severity was performed. The obtained data were compared with the results of X-ray examinations, intraoperative findings and pathomorphological conclusions. It was showed that polymorphic changes accompanying a renal injury can be differentiated based on the identification of specific morphodynamic stereotypes – permanent evolving signs that accompany, in particular: bruising (contusion) of the kidney, tissue integrity disorders, hemorrhagic manifestations, intra-organ vascular obstruction and acute post-traumatic inflammation. Each of the presented stereotypes is comparable with the corresponding manifestations of pathomorphogenesis of traumatic damage to the renal tissue. Conclusion. Echographic data, clearly correlated with changes in the morphological substrate, determine the ultrasound semiotics of kidney injury. This allows us to identify and predict the development of each stereotype in a timely manner, with the selection of the dominant (clinically most significant) at the time of the study, which in due time can be used for a rational choice of organ-preserving treatment tactics.
The Use of Hyperspectral Imaging in Intraoperative Determination of the Boundaries of the Spread of Ovarian Cancer
Authors:   A.I. Burnasyan Federal Medical Biophysical Center, Moscow, Russia, Zavyalov A.A. , Andreev D.A. ,   Scientific-Clinical Department, The State Budgetary Institution «Research Institute for Healthcare Organization and Medical Management of Moscow Health Department», Varlamova S.E. ,   A.I. Burnasyan Federal Medical Biophysical Center, Moscow, Russia
Published: December 2022

A serious challenge for physicians performing surgical removal of tumors is the need to further improve the effectiveness of oncosurgical interventions that maximally implement the principles of ablastic and antiblastic. All over the world, new approaches to intraoperative imaging of the prevalence of the tumor process are being actively developed, based on the use of new medical technologies and equipment, which makes it possible to detect differences between normal and tumor tissues, which are extremely difficult to distinguish with the naked eye. For these purposes. a visualization system based on a special auxiliary hyperspectral camera was created. Doctors-researchers are already actively using it for the most complete fixation of the prevalence of ovarian cancer, directly during surgery, in the space of the abdominal cavity. Further improvement of the presented imaging technology will make it possible to use it for tumors of other localizations, with a wide variety of diagnostic and oncosurgical procedures
A New Taxon of Salvia (Lamiaceae) From Türki̇Ye
Authors: Eminagaoglu ÖZgür , Ozcan Melahat , Beğen Hayal Akyildirim
Published: December 2022

Salvia divaricata Montbret & Aucher ex Benth. subsp. artvinense Eminagaoglu, Ozcan & Akyıldırım is described as a new endemic subspecies from Ardanuç (Artvin, Türkiye). It is related to Salvia divaricata Montbret & Aucher ex Benth. and S. tomentosa Mill. from which it differs in stem, leaf characters and flower color and numbers. A key is given to distinguish the new subspecies from the other species in the genus Salvia. Morphology, stem, petiole and leaf anatomy, and nutlet micromorphology were investigated. Nearly rounded stem, hemispherical petiole, bifacial leaf with diacytic stomata, and ovoid to rotund nutlet with glabrous and distinctly rough to protuberances ornamentation were determined for this subspecies. Taxonomic interpretations of the new subspecies are given using morphological, anatomical and phylogenetic analyses.
Bangladesh J. Plant Taxon. 29(2): 167-181, 2022 (December)
Estudio de factibilidad para la implementación de una farmacia en la Ciudad de Cuenca
Authors: Astudillo-Reyes Juan , Lugo-Garcia Jorge
Published: December 2022

El resultado de la pandemia desembocó en un incremento de la necesidad de nuevas casas farmacéuticas, la crisis sanitaria generó la oportunidad de crear emprendimientos o empresas para la comercialización de medicamentos e insumos médicos, lo cual converge en el planteamiento del presente estudio cuyo objetivo se centra en determinar la factibilidad de la implementación de una farmacia en la ciudad de Cuenca. Desde un enfoque sistémico implica proponer la prestación de un servicio con el empleo de una determinada técnica para establecer un emprendimiento; ahora bien,  desde el campo metodológico la investigación tuvo una alineación no experimental, en virtud que no se manipularon las variables, el enfoque del estudio fue cuantitativo ya que se sustentó en la revisión de las características del análisis de viabilidad y los beneficios sociales que brindará el proyecto a la población objeto de estudio, para ello se han realizado los erudiciones pertinentes para determinar de una manera técnica y económica la posibilidad de implementar el  negocio para beneficio de los emprendedores y los posibles clientes.
TINDAK TUTUR ILOKUSI HABIB JA’FAR DALAM VIDEO “KULTUM PEMUDA TERSESAT” PADA KANAL YOUTUBE MAJELIS LUCU INDONESIA
Authors: Putro Rizqi Pratomo , Resticka Gita Anggria , Nurdiyanto Erwita
Published: December 2022

Penelitian ini merupakan penelitian dekripsti kualitatif. Penelitian ini bertujuan mendeskripsikan jenis tindak tutur Habib Ja’far dan implikatur yang terkandung dalam video “Kultum Pemuda Tersesat”. Metode análisis data menggunakan metode padan pragmatis pada data dari tuturan Habib Ja’far yang mengandung tindak tutur dan implikatur. Hasil penelitian dan pembahasan dapat diambil kesimpulan bahwa terdapat tindak tutur ilokusi yang meliputi: (a) tindak tutur verdiktif yang terdiri atas penilaian; (b) tindak tutur eksersitif tuturan melarang, tuturan menyuruh, tuturan menasehati, dan tuturan menyarankan; (c) tindak tutur ekspositif terdiri atas tuturan menolak dan tuturan menjawab ; (c) tindak tutur ekspresif.
NILAI FILSAFAT ETIKA DALAM TIGA LAGU DAERAH SUMATERA SELATAN
Authors: Hidajati Enny
Published: December 2022

Philosophy is a science that is closely related to human life. Ethical philosophy is the basis for humans to seek the truth and the nature of life. Regional songs have deep ethical philosophical values ​​as a provision for the lives of the younger generation. This study aims to discuss the value of ethical philosophy in three folk songs in South Sumatra, namely Dek Sangke, Cuk Mailang, and Sukat Malang. The results showed that there were values ​​of honesty, politeness and self-control, as well as empathy in the three songs.
WOMEN OPPRESSION AND STRUGGLE IN THE NOVEL MOXIE BY JENNIFER MATHIEU
Authors: Yanti Cita Hikmah , Anggraini Dini
Published: December 2022

This study aims to analyze women oppression and struggle in the novel Moxie, this novel tells East Rockport Highschool because sexism and the patriarchy system act as triggers for sexual violence and sexism in schools. The purpose of this study was to determine the typesof oppressions that occur in novel Moxie and to determine women's struggle to the oppression. Using Marion Young's iris theory to find out various kinds of oppressions that occur in novel Moxie and women's resistance using 2 theories of feminism, namely radical feminism by Alison M. Jaggar is used to analyze how the patriarchy system triggers sexual coercion and multicultural feminism. This theory is used to analyze the patriarchy system that triggers sexual coercion that happens because of race and black skin. The research methodology in this research is qualitative descriptive, where relevant data is collected from the text or words found in the novel Moxie. This research resulted in womens oppression such as sexualharrassment, intimidation, and rape as a form of sexual coercion contained in novel moxie. This research also shows how women struggle against oppression that occurs becauseof the patriarchy system and sexism in schools.
Relación entre el uso de las TAC y las competencias digitales en universitarios del Perú
Authors: Carrión Ramos Roque Vladimir
Published: December 2022

El estudio tuvo como objetivo diagnosticar las variables uso de las tecnologías del aprendizaje y del conocimiento –TAC- y las competencias digitales, así como la relación entre ellas. La investigación fue cuantitativa, básica, correlacional y con diseño no experimental transversal, no se manipuló las variables en estudio, realizado en un tiempo determinado. Muestra censal, conformada por 151 estudiantes de las especialidades de inicial, primaria y secundaria del IX semestre de la Escuela Profesional de Educación de la Universidad Nacional Mayor de San Marcos. Para el análisis estadístico de la información recogida, se administraron los instrumentos CUTIC de Jiménez, Alvarado y Llopis (2017) y el CDAES de Gutiérrez, Cabero y Estrada (2017). Los resultados concluyeron que no existe relación entre las variables del estudio, la prueba Ji cuadrado alcanzó un valor de .060, lo que señala la necesidad de incluir y utilizar adecuadamentelas TAC dentro de los planes curriculares de la formación universitaria de los estudiantes de Educación para así contribuir en la adquisición de las competencias digitales y puedan ser aprovechadas de la mejor maneraen su futuro desenvolvimiento profesional.
Educación y TIC. Acceso y uso del internet en Ixiamas - Bolivia
Authors: Llanos Torrico Patricia , Medina Revilla Antonio , Medina Domínguez María
Published: December 2022

Se presentan los resultados de la investigación que indagó acerca de la educación y las Tecnologías de las Información en Ixiamas, provincia frontera de Bolivia. Se tuvo como objetivos detectar el acceso y uso del internet, identificar los factores que dificultan la aplicación de las TIC en el proceso enseñanza – aprendizaje y conocer el comportamiento de los estudiantes de secundaria con relación a procesos educativos virtuales; se utilizó metodología mixta y descriptiva. Se encuentra que las políticas de integración digital del Estado Plurinacional de Bolivia no se ha aplicado en la localidad de estudio, no existen condiciones técnicas ni tecnológicas para la implementación de educación en línea, por lo que el gobierno ha recurrido a la televisión y a la radio en este tipo de regiones para no retrasar ni marginarlos en materia educativa.
The Processes of Electron-Positron Scattering for Electroweak Theory Investigation
Authors: Chudnova Yu. N. , Shishkina T. V.
Published: December 2022

Studies of scattering processes at linear colliders of the new generation, when the interaction energy reaches several TeV, make it possible to obtain impressive results. To obtain precise research results, it is important to perform a comparative analysis of the processes of particle interaction on electron-positron, electron-photon and photon-photon beams in order to clarify kinematic features of various processes, as well as possibilities of building a program for studying extended calibration models. The process of production of muon-antimuon, taon-antitaon, and quark-antiquark pairs as a result of high-energy electron and positron annihilation is calculated. A numerical analysis of the differential and total cross sections of the process, as well as the asymmetry of forward-backward departure, has been performed. A study of the ultrarelativistic approximation has been carried out; it has been found that it effectively describes the cross sections of the process. A comparative analysis of the process cross sections for various types of final particles has been carried out.
PENGARUH KOMPETENSI, INDEPENDENSI, DAN BUDAYA KERJA TERHADAP KINERJA AUDITOR INTERNAL PADA SEKDA KABUPATEN PANDEGLANG
Authors: Masfufah Siti , Mulya Ali Sandy
Published: December 2022

Penelitian ini mempunyai tujuan untuk menguji pengaruh kompetensi, independensi dan budaya kerja secara simultan terhadap kinerja auditor internal. Populasi dalam penelitian sebanyak 177 orang dengan ukuran sampel sebanyak 64 orang. Teknik pengumpulan sampel dilakukan dengan teknik proportional random sampling.  Penelitian ini menggunakan metode kuantitatif dengan jenis penelitian survey dan analisis datanya memakai uji linear regresi berganda. Sedangkan teknik pengumpulan data menggunakan instrumen kuesioner. Hasil penelitian menunjukkan bahwa terdapat pengaruh yang signifikan kompetensi, independensi dan budaya kerja secara simultan terhadap kinerja auditor internal pada Sekretarat Daerah Kabupaten Pandeglang. Hasil temuan penelitian ini memberikan kontribusi atau sumbangsih kepada Pemerintah Daerah Kabupaten Pandeglang dalam rangka untuk meningkatkan kompetensi, independensi dan budaya kerja auditor internal dengan baik, sehingga dengan demikian dapat meninggkatkan kinerja auditor internal dalam melaksanakan pemeriksaan laporan keuangan pada Sekretariat Daerah Kabupaten Pandeglang.
Определение срока безопасной эксплуатации производственных зданий и сооружений
Authors: ЕФРЕМОВ Александр Михайлович , БОЙКО Вадим Дмитриевич , СЕРГЕЕВЦЕВ Евгений Юрьевич , ТРЕКИН Николай Николаевич , КОДЫШ Эмиль Наумович , ТЕРЕХОВ Иван Александрович , ШМАКОВ Сергей Дмитриевич
Published: December 2022

Статья содержит методику определения срока безопасной эксплуатации производственных зданий и сооружений, основанную на результатах установления категории технического состояния объектов строительства по визуальным признакам. Для выработки подхода к определению срока безопасной эксплуатации были проанализированы различные методики оценки категории технического состояния зданий и сооружений. Проведен анализ более трех тысяч объектов с известной датой последнего капитального ремонта, имеющих различные сроки эксплуатации, построены графики зависимости коэффициента снижения несущей способности от срока эксплуатации объекта строительства на протяжении жизненного цикла для каменных, железобетонных и металлических конструкций производственных зданий и сооружений. Выявлена усредненная функция деградации строительных конструкций, показавшая значительную сходимость с данными, представленными в других работах. Исходя из постулатов безопасной эксплуатации объектов строительства, сформулирован подход к определению срока безопасной эксплуатации производственных зданий и сооружений с учетом проводимых текущих и капитальных ремонтов. Методика проиллюстрирована на примере наиболее часто применяемых в строительстве элементов - железобетонных плит.
Legal status of persons affected by the military aggression of the Russian Federation against Ukraine (constitutional and legal aspect)
Authors: Ternavska V. M.
Published: December 2022

Ukraine as a social, legal state forms the national external and internal policy on the basis of guaranteeing and unconditional provision of rights and freedoms of man and citizen, proclaimed by the Constitution of Ukraine. At the same time, certain categories of citizens today need special state support because of the military aggression of the Russian Federation against Ukraine. This issue has heightened social and legal significance because the number of persons who lost their property, became the victims of physical and psychological torture, sexual violence in the result of war crimes committed by the Russian military has much increased compared to 2014-2021. Many children are among the injured and dead. The question of proper provision and protection of the constitutional rights and freedoms of aggrieved persons is a priority issue of the constitutional and legal policy of Ukraine today. However, the granting a necessary support by the state requires the formal assignment of the appropriate legal status to each category of persons. The urgency of resolving these questions under the state of martial law actualizes the issue of proper defining the characteristics of legal status of each category of Ukrainian citizens affected by the military (armed) aggression of the Russian Federation against Ukraine.

In the article there investigated various theoretical approaches to determining the legal status of an internally displaced person. The ratio of the categories “internally displaced person”, “migrant” and “refugee” is analyzed by studying the provisions of Ukrainian and foreign constitutional legislation as well as international legal documents. There determined the defects of the constitutional legislation of Ukraine in matters of legal regulation of the legal status of citizens of Ukraine, including children, and foreigners, who suffered in a result of military (armed) aggression of the Russian Federation against Ukraine, due to the inconsistency of the constitutional and legal policy of Ukraine. It is concluded that the current constitutional and legal policy of Ukraine should be formed more considerably and according to national interests, not only under the impact of international experts’ recommendations, timely take into account new legal facts, that will permit to avoid lacunae and collisions in national legislation in future.

Key words: constitutional and legal policy, legal status, internally displaced person, deportation, military aggression
The principle of independence of a lawyer in the aspect of relationships with public authorities
Authors: Boiko M. M.
Published: December 2022

The Bar of Ukraine has been an independent self-governing organization for over 10 years. Legislative regulation of the bar and advocacy should not be understood as limiting the independence of the bar or as an attack on its independence, but, on the contrary, should be seen as in line with the principles of legal certainty and the rule of law. The place of the bar in a state governed by the rule of law and democracy is determined by its special status, according to which it acts as an independent institution that performs a public law function and is not subordinate to public authorities.

Independence is a fundamental principle that determines the status of the bar and correlates with the rule of law. This allows to embody the ideas of justice and professionally protect human rights, thereby contributing to the development of legal culture and legal consciousness of society.

Self-regulation of the legal profession means the implementation of democratic principles in the organization and activities of the legal profession, the lack of regulation and control by public authorities and guaranteeing professional independence of the legal profession. Accordingly, the bar operates outside politics and is independent in its relations with all subjects of power, both at the regional and state levels.

Public authorities must be interested in the existence of an independent and strong legal profession, without which the rule of law and the functioning of civil society institutions are impossible. At the same time, the state, which positions itself as a legal entity, should be interested in the bar being a highly professional institution. The interaction between public authorities and the bar should be formed on the basis of partnership and joint efforts in building the rule of law.

The implementation of the principle of independence should guarantee all subjects of advocacy self-government at the legislative level the exclusive right to independently decide on issues of self-government and self-regulation. Bar associations must uphold the public value of the bar and guarantee the independence of lawyers, ensuring compliance with professional and ethical standards, protection from persecution and any influence aimed at restricting the principle of independence in their professional activities.

Key words: independence principle, the Bar, advocacy self-government, self-regulation, framework law
Features of monetary obligations in the integrated taxpayer card during administrative or judicial appeals
Authors: Shokruta V. A.
Published: December 2022

The article is devoted to the analysis of current legal and theoretical features of the reflection of monetary obligations in the integrated card of the taxpayer during administrative or judicial appeals.The tax authorities of Ukraine often violate the rights and legitimate interests of taxpayers in the exercise of their powers, including the conduct of tax audits and fixing its results in the relevant documentation. Tax audit is a special type of state financial control provided by the tax authorities of Ukraine. There are different types of tax audits and have their own characteristics of the researching the timeliness of financial reporting and payment of taxes and fees in full by the taxpayer. According to the results of the tax audit, the information should be included in the tax documentation of the taxpayer, but recently they enter such information with errors and sometimes violating the deadlines for entering such information. The display of inaccurate information in the integrated cards of taxpayers on the presence or absence of tax debt is the subject of a significant number of disputes with the authorities. Improving the mechanism for including operational information on the accrual of monetary liabilities in the tax documentation of taxpayers is an important issue that needs due attention, as it concerns the possible violation of their legal rights and interests. The process of administrative and judicial appeal of the amount of monetary liabilities determined by the results of the tax audit has its own features that must be considered by the tax authorities when displaying tax information in the integrated cards of taxpayers.Therefore, we investigated various methodological aspects of entering information about the taxpayer’s monetary obligations based on the results of the tax audit into the relevant information system, which provides the formation of integrated taxpayer cards. The peculiarities of the mechanism of interaction of subjects of state power are considered. The process of administrative and judicial appeal of certain amounts of monetary obligations of the taxpayer is analyzed. The peculiarities of the mechanism of providing information by judicial authorities to the tax authorities in order to include operational information on the accrual of monetary liabilities in the tax documentation of taxpayers are studied. A scientific analysis of some theoretical issues, the solution of which is related to the improvement of the legislation of Ukraine governing this area of relations.

Key words: tax relations, taxes, judicial appeal, executive branch, administrative appeal.
Current issues of standardization of antinuclear antibodies’ detection by indirect immunofluorescence on HEp-2 cells
Authors: Aleksandrova E. N. , Novikov A. A. , Kazakov S. P. , Klyukvina N. G. , Vasiliev V. I. , Lukina G. V.
Published: December 2022

Background. Antinuclear antibodies (ANA) are a group of antibodies that target nuclear and cytoplasmic antigens. Testing for ANA using an immunofluorescence assay (IFA) on HЕp-2 cell (IFA-HEp-2) is a screening test for the diagnosis of systemic autoimmune rheumatic diseases, druginduced lupus erythematosus, autoimmune liver diseases, juvenile idiopathic arthritis. In routine ANA testing final report forms bears important, but unstandardized variables (e. g., screening and final titers of ANA, coding of glow types, the procedure for performing confirmatory tests). Aim of the study. Develop a standard report form for IFA-HEp-2 testing results.

Material and methods. Survey of 10 immunological and clinical diagnostic laboratories using the ICAP questionnaire adapted by the Working Group on Standardization of the definition of ANA by the IFA-HEp-2 method (Committee on Immunology of the Association ‘Federation of Laboratory Medicine’).

Results. According to the results of a survey: most of the participants use a screening dilution of serum 1:160; indicates the maximum end titer of antinuclear factor (ANF), cytoplasmic staining; identifies staining types (including AC encoding); considers it mandatory to make confirmatory tests to detect ANA to individual nuclear antigens in ANF-positive patients, but does not provide a list of this tests in the results form; describes ANF titer for each of the detected glows separately; designates ANF titers using a colon and does not give a clinical interpretation of the results. Based on interlaboratory consensus, ICAP recommendations and the requirements of ISO 15189, the standard report form for IFA-HEp-2 testing results was developed.

Conclusions. To achieve high quality of interaction between clinical diagnostic/immunological laboratories and clinical departments of health care facilities, it’s necessary to introduce into practice a standard form for IFA-HEp-2 testing results, developed relying on modern clinical recommendations and interlaboratory consensus.
Relevance of studying axial syndrome in spondyloarthritis (review of literature)
Authors: Ivanova L. V. , Akulinushkina E. Yu. , Lapshina S. A. , Abdulganieva D. I.
Published: December 2022

The article reports the problems of sacroiliitis and spondylitis in patients with ankylosing spondylitis and psoriatic arthritis. Based on the concept of primary involvement the sacroiliac joint in inflammation, they are most often is the object of investigations. But inflammatory changes also affect the spine that’s called the spondylitis. Due to the widespread introduction of medical imaging, scientists know the various variants of axial characteristic in inflammatory spondylopathies: angular (Romanus lesion) and non-angular spondylitis (Andersson lesion, osteitis of the arch, inflammation of the facet joints). However, generally accepted criteria for assessing inflammation of the spinal column in these pathologies have not been developed. Also, frequency of these lesions is not researched. Further study of various variants of spondylitis in ankylosing spondylitis and psoriatic arthritis is necessary, since these data will significantly contribute to the understanding of axial involvement in inflammatory spondylopathies.
Faktor Risiko Kanker Serviks: Literature Review
Authors: Khabibah Umu , Adyani Kartika , Rahmawati Alfiah
Published: December 2022

Kanker serviks disebabkan oleh infeksi Human Papilloma Virus (HPV) yang tumbuh di dalam leher rahim dan mengakibatkan terjadinya tumor ganas. Kanker serviks menempati urutan keempat terbanyak kanker pada wanita di dunia. Tujuan penelitian ini adalah untuk mengetahui faktor risiko kanker serviks. Dengan kejadian kanker serviks di kalangan masyarakat, penelitian ini menggunakan studi Literatur. Penelusuran menggunakan database PubMed dan Google Scholar tahun publikasi 2017 sampai dengan 2020 dan mendapatkan 12 artikel yang relevan berdasarkan kriteria inklusi. Hasil review menunjukkan bahwa kanker serviks bisa disebabkan oleh faktor risiko melakukan aktivitas seksual usia dini, penggunaan tembakau rokok, penggunaan kontrasepsi hormonal, dan memiliki >1 pasangan seksual. Terdapat kaitan faktor risiko terjadinya kanker serviks antara melakukan aktivitas seksual usia dini (< 20 tahun), penggunaan tembakau rokok, menggunakan kontrasepsi hormonal ≥5 tahun, dan memiliki >1 pasangan seksual. Tenaga medis dan fasilitas pelayanan kesehatan penting melakukan pendekatan pemberian edukasi kepada masyarakat tentang faktor risiko kanker serviks agar masyarakat mengetahui dampak, bahaya dan pencegahan kanker serviks.
Pengaruh Pemberian Edukasi Berbasis Digital Cardicraf terhadap Tingkat Kepatuhan Monitoring Self-Care Management Pasien Gagal Jantung
Authors: Rahmawati Dewi , Hardiyanti Fina Catur , Fauziyah Siti Iyah , Nur Falakh Indah Mae , Nurhidayat Trisna , Algifari Triyandi
Published: December 2022

Prevalensi morbiditas dan mortalitas kasus gagal jantung saat ini semakin meningkat, menyebabkan pengobatan dan perawatan kompleks serta kejadian rehospitalisasi. Selain itu, komplikasi yang terjadi berdampak pada penurunan kualitas hidup pasien. Salah satu upaya mencegah perburukan kondisi adalah melalui self-care management yang dapat ditingkatkan melalui edukasi berbasis digital. Tujuan penelitian ini untuk mengetahui pengaruh pemberian edukasi melalui media aplikasi digital Cardicraf terhadap kepatuhan self-care management penderita gagal jantung. Desain penelitian menggunakan quasy experiment dengan one group pre dan post-test without control group. Sampel penelitian sebanyak 25 responden berdasarkan kriteria inklusi dengan teknik purposive sampling. Instrumen penelitian menggunakan Morisky 8-item Medication Adherence Questionnaire dan Self-Care of Heart Failure Index (SCHFI). Analisis data penelitian ini menggunakan paired sample t-test. Hasil penelitian menunjukkan rata-rata kepatuhan self-care management sebelum intervensi aplikasi digital Cardicraf adalah 59,92 dan sesudahnya adalah 85,75. Hasil uji statistik mendapatkan p value 0,000 sehingga disimpulkan terdapat pengaruh pemberian edukasi dengan Cardicraf terhadap kepatuhan self-care management pasien gagal jantung. Aplikasi ini memerlukan penyempurnaan untuk dapat didaftarkan pada platform playstore agar dapat digunakan secara lebih luas dan mudah oleh masyarakat dan membantu tenaga kesehatan dalam pengkajian dan monitoring pada pasien gagal jantung.
Nursing Students Experience in Learning of Caring
Authors: Mujiyanti Sri , Haryani Ani , Rachmaniah Dini
Published: December 2022

Professional value is needed in professional nursing practice. Caring plays an important role for nursing students in providing nursing intervention to clients. The purpose of the study was to determine the phenomenon of the student learning process of caring to improve their caring competence. The study used a descriptive qualitative design of phenomenology. The number of participants was 15 students, both at the academic and internship levels. Convenience sampling and analysis content were used to analyze data. The result of this study found three themes with eight categories. The first theme, caring was focused on physical, psychological, social, and spiritual conditions aimed at patient’s healing. The second theme, caring was influenced by themselves, family, and the learning environment. The Third theme students need competent lecturers, adequate facilities, and good learning strategies to improve their caring competence. Learning that focuses on increasing students' caring competence become a need felt by nursing students. Lecturers and faculty need to review the existing curriculum and curriculum tools to ensure that these needs are met.
Determinan Faktor Risiko Kejadian Stunting Berdasarkan Pemetaan Kasus Stunting pada Balita dengan Geographic Information System (GIS)
Authors: Purwadi Happy Novriyanti , Oktaviani Dessy , Latief Kamaluddin
Published: December 2022

Stunting adalah kelainan pada berat badan dan tinggi badan bayi atau balita dibandingkan dengan umur. Berdasarkan data dari Riset Kesehatan Dasar tahun 2018 jumlah kasus stunting di Indonesia cukup tinggi (30.8%). Penelitian ini bertujuan untuk mengetahui faktor risiko stunting berdasarkan data pemetaan stunting dengan Geographic Information System (GIS) pada balita. Penelitian ini merupakan penelitian kuantitatif dan menggunakan desain case control. Uji statistik yang digunakan adalah chi-square dan teknik pengambilan sample menggunakan simple random sampling. Populasi penelitian sebanyak 110 balita dan jumlah sampel sebanyak 50 balita sebagai kasus dan 50 balita sebagai kontrol. Wilayah kerja Puskesmas Legok memiliki sebaran kejadian stunting di Desa Rancagong sebanyak 32 titik, Desa Serdang Wetan 9 titik, dan Desa Legok 9 titik. Hasil Penelitian menunjukan bahwa variabel ASI ekslusif (p=0,543), berat badan lahir (p=0,093), penyakit infeksi (p=0,141), pendidikan terakhir ibu (p=0,830), pengetahuan gizi ibu (p=1,000), pola asuh makan (p=0,541), tinggi badan ibu (p=1,000), dan tinggi badan ayah (p=0,111) tidak berhubungan dengan kejadian stunting. Pemantauan status gizi balita serta pencegahan kepada sasaran yang tepat guna perlu dipertahankan dan ditingkatkan untuk mencegah kejadian stunting.
Terapi Non-Farmakologi untuk Mengatasi Nyeri Dismenore pada Remaja
Authors: Khotimah Husnul , Lintang Santi Sundary
Published: December 2022

Salah satu keluhan selama menstrusasi adalah dismenore. Terapi non-farmakologi menjadi alternatif utama penyelesaian dismenore. Tetapi masih sedikit penelitian membahasnya. Penelitian ini bertujuan untuk menganalisis berbagai terapi non-farmakologi (aromaterapi, kompres hangat, relaksasi pernafasan dalam, terapi musik, dan latihan fisik) untuk mengatasi nyeri dismenore pada remaja. Penelitian ini menggunakan rancangan pre experiment pretest-posttest design. Dari 114 jumlah populasi, sampel diambil dengan teknik kuota sampling dan berjumlah 65 orang remaja. Analisis data penelitian menggunakan Wilcoxon signed-rank test. Hasil penelitian menunjukkan bahwa kelima terapi non-farmakologi dapat mengatasi nyeri dismenore pada remaja dengan nilai P 0,001 untuk aromaterapi, nilai P 0,001 untuk kompres hangat, nilai P 0,004 untuk relaksasi pernapasan dalam, nilai P 0,001 untuk terapi musik, dan nilai P 0,001 untuk latihan fisik. Terapi musik dan latihan fisik memberikan dampak penurunan yang lebih besar terhadap nyeri dismenore.  Remaja dapat melakukan hal-hal yang disenangi sebagai terapi non-farmakologi untuk mengalihkan rasa nyeri akibat dismenore sehingga aktivitas sehari-hari tidak terganggu dan bisa lebih produktif.
Dampak Paparan Merkuri Terhadap Gangguan Kesehatan Penambang Emas Skala Kecil: Systematic Review
Authors: Bagia Murniwati , Setiani Onny , Rahardjo Mursid
Published: December 2022

Pemakaian Merkuri (Hg) untuk pemisahan emas dari batuan (amalgamasi) sangat berbahaya pada kesehatan dimana dapat nebimbulkan gangguan kesehatan. Paparan Hg terjadi akibat mengkonsumsi makanan atau air yang mengandung merkuri atau menghirup partikel merkuri. Tujuan systematic review yaitu untuk mengetahui dampak paparan merkuri terhadap gangguan kesehatan penambang emas skala kecil. Penelusuran literatur artikel terkait dengan menelusuri artikel di jurnal-jurnal PubMed, Researchgate, google scholar search, ChemPubSoc Europe, International Journal of Environment Research and Public Health (IJERP), semanticscholar, International Journal of Education And Research (IJERN) dan Science Direct, geosciences, dan jurnal nasional melalui Portal Garuda Indonesia, Indonesia Widget One Search yang dipublish tahun 2012 hingga tahun 2022 dengan kata kunci “paparan merkuri penambang emas tradsional”. Hasil penelitian yaitu terdapat 6 artikel yang menunjukkan bahwa adanya gejala gangguan neurologis dan 5 artikel lainnya menunjukan adanya gejala gangguan fungsi hati dan ginjal (1), gangguan neurologis dan ginjal (1), gangguan fungsi hati (1) serta gangguan kesehatan lainnya tanpa menyebutkan gangguan kesehatan spesifik (3). Penggunaan merkuri pada pengolahan emas dalam jangka waktu lama sangat berdampak pada kesehatan
Knowledge gaps in food allergy among the general public in Jeddah, Saudi Arabia: Insights based on the Chicago food allergy research survey
Authors: Takrouni Abdulrahman Ahmad , Omer Ibrahim , Alasmari Faisal , Islamuldeen Suhayb , Ghazzawi Amr Yasser , Zahrani Mohammed Ibrahim , Ahmed Mohamed Eldigire , Abushouk Amir
Published: December 2022

Background

Food allergy is an increasing health concern. Studies have shown that food allergy knowledge is lacking among people, especially in areas related to distinction between food allergy and intolerance, symptoms recognition, and current means of management. This knowledge gap puts allergic patients at more risk of getting fatal anaphylactic reactions, which occur mostly in public areas. Locally, Public's knowledge and attitudes of food allergy was not sufficiently investigated. Therefore, we aim to assess food allergy knowledge and attitudes among Jeddah population in Saudi Arabia.

Methods

We adopted The Chicago Food Allergy Research Survey for the General Public (CFARS-GP) and used it as a data collection tool. We hosted the questionnaire on Google Forms and distributed the link through social media outlets targeting individuals of Jeddah population who are 18 years old and above.

Results

A total of 510 individuals completed the survey. The respondents answered 56% of the knowledge-based items correctly. Knowledge was strongest in symptoms/severity and definition/diagnosis, while it was weakest in susceptibility and prevalence, distinction between food allergy and intolerance, and food allergy management. Higher knowledge was significantly associated with prior training in food allergy, food-allergic acquaintance (i.e., having food allergy or knowing an allergic patient), and being a relative of a health care worker. For the attitudes, respondents thought that food allergy negatively affects patients' quality of life, and that schools should establish policies to protect allergic children; however, they downplayed stigma associated with food allergy.

Conclusion

Increased food allergy knowledge among the general public is needed especially in areas related to susceptibility and prevalence, distinction between food allergy and intolerance, triggers and environmental risks, and the management of food allergy. Prior experience with food allergy through (1) training, (2) food-allergic acquaintance, or (3) being a relative of a health care worker increases food allergy knowledge significantly. Thus, targeted educational interventions might have a significant effect in improving food allergy knowledge among the general population.
Plant production of high affinity nanobodies that block SARS-CoV-2 spike protein binding with its receptor, human angiotensin converting enzyme
Authors: Pitino Marco , Fleites Laura A. , Shrum Lauren , Heck Michelle , Shatters Robert G.
Published: December 2022

Nanobodies® (VHH antibodies), are small peptides that represent the antigen binding domain, VHH of unique single domain antibodies (heavy chain only antibodies, HcAb) derived from camelids. Here, we demonstrate production of VHH nanobodies against the SARS-CoV-2 spike proteins in the solanaceous plant Nicotiana benthamiana through transient expression and their subsequent detection verified through western blot. We demonstrate that these nanobodies competitively inhibit binding between the SARS-CoV-2 spike protein receptor binding domain and its human receptor protein, angiotensin converting enzyme 2. There has been significant interest and a number of publications on the use of plants as biofactories and even some reports of producing nanobodies in plants. Our data demonstrate that functional nanobodies blocking a process necessary to initiate SARS-CoV-2 infection into mammalian cells can be produced in plants. This opens the alternative of using plants in a scheme to rapidly respond to therapeutic needs for emerging pathogens in human medicine and agriculture.
Research progress of stimulus-responsive antibacterial materials for bone infection
Authors: Wang Changqing , Xu Peng , Li Xiaoxu , Zheng Yuhao , Song Zhiming
Published: December 2022

Infection is one of the most serious complications harmful to human health, which brings a huge burden to human health. Bone infection is one of the most common and serious complications of fracture and orthopaedic surgery. Antibacterial treatment is the premise of bone defect healing. Among all the antibacterial strategies, irritant antibacterial materials have unique advantages and the ability of targeted therapy. In this review, we focus on the research progress of irritating materials, the development of antibacterial materials and their advantages and disadvantages potential applications in bone infection.
Alternative neural systems: What is a neuron? (Ctenophores, sponges and placozoans)
Authors: Moroz Leonid L. , Romanova Daria Y.
Published: December 2022

How to make a neuron, a synapse, and a neural circuit? Is there only one ‘design’ for a neural architecture with a universally shared genomic blueprint across species? The brief answer is “No.” Four early divergent lineages from the nerveless common ancestor of all animals independently evolved distinct neuroid-type integrative systems. One of these is a subset of neural nets in comb jellies with unique synapses; the second lineage is the well-known Cnidaria + Bilateria; the two others are non-synaptic neuroid systems in sponges and placozoans. By integrating scRNA-seq and microscopy data, we revise the definition of neurons as synaptically-coupled polarized and highly heterogenous secretory cells at the top of behavioral hierarchies with learning capabilities. This physiological (not phylogenetic) definition separates ‘true’ neurons from non-synaptically and gap junction-coupled integrative systems executing more stereotyped behaviors. Growing evidence supports the hypothesis of multiple origins of neurons and synapses. Thus, many non-bilaterian and bilaterian neuronal classes, circuits or systems are considered functional rather than genetic categories, composed of non-homologous cell types. In summary, little-explored examples of convergent neuronal evolution in representatives of early branching metazoans provide conceptually novel microanatomical and physiological architectures of behavioral controls in animals with prospects of neuro-engineering and synthetic biology.
Discovery of novel spike/ACE2 inhibitory macrocycles using in silico reinforcement learning
Authors: Shapira Lev , Lerner Shaul , Assayag Guila , Vardi Alexandra , Haham Dikla , Bar Gideon , Kozokaro Vicky Fidelsky , Robicsek Maayan Elias , Lerner Immanuel , Michaeli Amit
Published: December 2022

Introduction: The COVID-19 pandemic has cast a heavy toll in human lives and global economics. COVID-19 is caused by the SARS-CoV-2 virus, which infects cells via its spike protein binding human ACE2.

Methods: To discover potential inhibitory peptidomimetic macrocycles for the spike/ACE2 complex we deployed Artificial Intelligence guided virtual screening with three distinct strategies: 1) Allosteric spike inhibitors 2) Competitive ACE2 inhibitors and 3) Competitive spike inhibitors. Screening was performed by docking macrocycles to the relevant sites, clustering and synthesizing cluster representatives. Synthesized molecules were screened for inhibition using AlphaLISA and RSV particles.

Results: All three strategies yielded inhibitory peptides, but only the competitive spike inhibitors showed “hit” level activity.

Discussion: These results suggest that direct inhibition of the spike RBD domain is the most attractive strategy for peptidomimetic, “head-to-tail” macrocycle drug development against the ongoing pandemic.
The factors controlling along-arc and across-arc variations of primitive arc magma compositions: A global perspective
Authors: Wang Jian , Gleeson Matthew , Smith William D. , Ma Lin , Lei Zhibin , Shi Guanghai , Chen Long
Published: December 2022

Arc volcanism is a key process influencing Earth’s climate, continental growth, and the formation of mineral deposits. Therefore in this contribution, we have compiled whole-rock geochemistry of frontal arc and rear-/back-arc basalts, crustal thickness, and slab parameters (e.g., slab age, slab dip, and convergence velocity) from global convergent margins to investigate the factors controlling along-arc and across-arc variations. Crustal thickness or lithosphere thickness plays a dominant role in elements immobile in aqueous fluids (e.g., Zr/Yb and Nb/Yb). The effect is imposed through mantle partial melting for both frontal arc and rear-/back-arc rocks. Slab thermal structure also affects these immobile elements and gives rise to along-arc variations. Both slab sediment and altered oceanic crust can melt especially in hot subduction zones which yield across-arc variations (e.g., Nd isotope). Aqueous fluids (represented by element ratios such as Ba/Nb and Sr/Nd) also show across-arc variations as they decrease toward rear-/back-arc. This meanwhile decreases mantle wedge melting as rear-/back-arcs show higher Zr/Yb and Nb/Yb. However, no correlations between aqueous fluids and slab parameters suggest aqueous fluids in arc rocks are controlled by complex processes. We summarize factors such as slab alteration, slab dehydration, and mantle metasomatism might impose an effect on the content of fluid mobile elements in arc rocks.