bluuebunny/crossref_metadata_2025 huggingface dataset:
Biochemical Analysis of Mineral Metabolism and Central Bone Mineral Density in 157 Adult Women
Authors: Bechir Edwin Sever , Carsote Mara , Tuculina Mihaela Jana , Bataiosu Marilena , Dascalu Ionela Teodora , Raescu Mihaela , Rica Radu , Daguci Constantin , Daguci Luminita , Predescu Anca , Andrei Oana Cella , Mercut Razvan , Cumpata Cristian Niky
Published: February 2020

This is a cross-sectional retrospective study of observational type. 157 menopausal subjects were included. A number of N1=89 were younger of 60 years old (also included) and a number of N2=68 were older than 60 years old. Median of age was of 55 years, respective 66 years.The biochemical parameters like total and ionic serum calcium, serum magnesium, and phosphorus between the two groups N1-N2 were similar (p]0.05).The median values of mentioned chemical elements were within normal limits.The bone turnover markers were not statistically significant different between N1 and N2. 25OHD was found deficient in both populations, irrespective of age. DXA- BMD and T-score N1-N2 difference was statistical significant for all the four central sites. Biochemical mineral parameters seem not to be influenced by the cut off of 60 years in menopausal women aged between 40 and 80 years. Yet, a large prevalence of hypovitaminosis D is identified regardless the age without secondary PTH raise. The statistical significant results are for BMD and T-score for all the four central sites.
Biochemical Changes of Dried Fruit of Figs (Ficus carica L.) During Storage
Authors: Dumitru Mihaela Gabriela
Published: February 2020

Fig (Ficus carica) is the fig tree, originating in the Mediterranean Basin, has a carnous and juicy pulp, besides being slightly sweetened. Fig is the highly perishable subtropical fruit, therefore, falls into high degradation due to biochemical changes that occur during storage. The purpose of this paper was to establish biochemical changes with a role in modifying the quality of fig fruit (Ficus carica) during the storage period. During storage, fruit containing oil is susceptible to oxidative damage. In order to ensure a high quality of fruit, it is essential to reliably analyze their oxidative status (complex process due to the influence of several factors such as availability of oxygen, light, temperature, microorganisms and enzymes). Samples were packed in 200 mm x 150 mm polyethylene sheets and stored under ambient conditions to study the quality changes during storage for 365 days. The samples were analyzed for quality attributes, such as the measurement of fatty acid profiles, determination of primary oxidation products (Peroxide value), determination of secondary oxidation products (Thiobarbituric acid test), acid value and the refraction index. can help to estimate the shelf life. The result of the study indicated the shelf life for Ficus carica fruit dried was 120 days.
Pharmacologic Therapy in Postpartum Pelvic Pain Management
Authors: Matei Alexandra , Ionescu Cringu , Dimitriu Mihai , Ilinca Corina , Gheorghiu Diana , Banacu Mihai , Calin Dan , Ples Liana , Neacsu Adrian , Rosu George
Published: February 2020

Women�s perception on childbirth experience is frequently related to pain struggle, regardless the type of birth. We aimed to present our Department�s experience on pharmacologically treating postpartum related pain. We developed a 6 months retrospective, descriptive study which included a number of 305 patients. Two sample patients were formed depending on the type of birth. In the sample of vaginal delivery a correlation between episiotomy and Paracetamol consumption was found (Pearson correlation of 0.238). In the sample of cesarean section births, for Acupan, Ketoprofen and Algifen the correlations with epidural anesthesia are negative and statistically significant at the 99.9% confidence level.
The Prevalence of Dental Midline Deviation in a Group of Orthodontic Patients
Authors: Anistoroaei Daniela , Zegan Georgeta , Saveanu Iulia Catalina , Sodor Alina , Golovcencu Loredana
Published: February 2020

The study aimed to determine the prevalence of dental midline deviation in an orthodontic group of patients.The study was performed on 384 orthodontic patients (164 boys and 220 girls), between 6-23 years old. The data collected from orthodontic records were analysed according to the gender, age stages, environments areas, type of dentition and Angle Classes of malocclusions. All analyses were carried out using the SPSS. In the studied group the prevalence of dental midline deviation was 20.70%. The prevalence of dental midline deviation was increased in girls (12.24%), in patients over 12 years old (8.35%), from urban areas (14.32%), with mixed dentition (11.45%) and with Class I (11.20%) and II division 1 (6.25%) malocclusions. We founded statistically significant high correlations between dental midline deviation and age stages (p=0.028), type of dentition (p=0.001) and Angle classes of malocclusions (p=0.006). The dental midline deviation, commonly encountered in orthodontic practice, must be accurately diagnosed from the beginning of the treatment because the symmetry of the midlines is an essential criterion in achieving the aesthetic and functional objectives of the orthodontic treatment.
The Role of Chemical Factors in the Inflammation and Infection of Cervico-facial Actinomicosis
Authors: Nechita Aurel , Constantin Mihai , Budacu Cristian , Raftu Gheorghe , Popa Cristina
Published: February 2020

Inflammation is a reflex reaction of the body to the action of some harmful agents, a reaction that manifests itself as a complex of functional and structural modifications of a vasculo-tisular nature, this reaction has occurred in the process of evolution. The intensity of the inflammatory reaction depends on the reactive properties of the body, the location of the inflammatory process, the anatomo-physiological particularities of the damaged tissue, and the conditions in which the inflammation develops. As accurate as dental technique and the practitioner�s skill, if the specific conditions of each patient are not taken into account, the benefit medical cannot rise to a higher level, with the final result being compromised by complications with unpredictable risks. Actinomycosis is a specific infection with subacute or chronic evolution, common to humans or animals, caused by microorganisms of the actinomycete family. The location of the affection in the cervico-facial sphere is four times bigger than the rest of the body; the disease is manifested by rough nodules, red in the cheek or sub-maxillary region, fistulas and scars on which new lesions appear. In order to achieve the proposed objectives, we conducted a study on a representative human sample of 158 patients, from the Oral and Maxillofacial Clinic, between 1.01.2013-31.12.2017. Risk factors (gender, age, area, dental anxiety score), our findings are unlikely to define separately the potential for the risk of installing actinomycosis. The level of dental anxiety as well as the general status of the patient are the markers that require the greatest attention from the practitioner in order to prevent a dental problem.
coRibavirin-induced Anemia in Patients with Chronic Hepatitis C Virus Infection
Authors: Taisescu Citto Iulian , Demetrian Alin , Biciusca Viorel , Dricu Anica , Artene Stefan Alexandru , Cioc Catalina , Taisescu Oana
Published: February 2020

Anemia associated with ribavirin (RBV) and interferon therapy in patients with chronic viral hepatitis C is a hemolytic, multifactorial adverse effect, in direct correlation with the RBV dose. Additionally, the anemic syndrome is worsened by the interferon-induced bone marrow suppression of erythroid precursors. The resulting anemia is associated with low production of erythropoietin, similar to anemia seen in HIV-infected patients or in those with cancer. Our study was performed on a group of 28 patients with viral hepatitis C treated with 3 MU interferon alfa 3 times a week and RBV 1000-1200 mg/day for 12 months. A normochromic normocytic anemia was observed, requiring a reduction of the RBV dose to 600 mg/day if the hemoglobin was below 10 g/dL and interrupted if the hemoglobin level was below 8.5 g/dL. In this case, reversibility can occur within a time interval of 4-8 weeks after discontinuation of treatment.
Chemical Ablation of the Soft Palate Neoplasm
Authors: Dumitras Meius Alexandru , Ghindea Teodora Ioana , Pietrosanu Catalina , Stefanescu Dragos Cristian , Ionita Irina , Rusescu Andreea , Zainea Viorel , Hainarosie Razvan
Published: February 2020

Approximately 2% of head and neck malignancies are represented by tumors of the soft palate. The main risk factors associated are smoking, alcohol abuse, human papilloma virus infections, poor oral hygiene, mechanical irritation. The treatment of the soft palate cancer depends on the staging of the tumor and of the pathologic type of the carcinoma. In this article, we will present coblation under endoscopic control as a new method of resection of the soft palate neoplasms.
The Study of Crystallization Dynamics of Amorphous Precursor Fe70Mo5Cr4Nb6B15 Alloy
Authors: Gruszka Konrad , Rzacki Jakub , Nabialek Marcin
Published: February 2020

The paper presents the results of studying the dynamics of the crystallization process for the samples subjected to three separate processes of isothermal heating with three different energy in the process. For this purpose, a series of samples prepared in the form of a ribbon of an amorphous structure, as confirmed from X-ray diffraction were then subjected to a controlled annealing. The research of samples after heat treatment revealed the presence of different crystalline phases that are characterized by different nucleation energies.
Finite Element Method Application for the Determination of Hardness for Magnesium Alloys
Authors: Sliwa Agata , Sroka Marek , Bloch Katarzyna , Sandu Ioan Gabriel , Al Bakri Abdullah Mohd Mustafa , Sandu Andrei Victor
Published: February 2020

A numerical model was made to establish the casting hardness for the magnesium alloys MCMgAl12Zn1, MCMgAl6Zn1, MCMgAl3Zn1 and MCMgAl9Zn1. Computer simulation of hardness was performed using the finite element method in ANSYS environment, and the hardness values were obtained by experiments based on the Rockwell method. The showed model fulfils the initial criteria, which provides with the basis for the assumption about its utility in establishing the casting hardness of the magnesium alloys MCMgAl12Zn1, MCMgAl6Zn1, MCMgAl3Zn1 and MCMgAl9Zn., using the finite element method within the framework of the ANSYS program. There is the correlation of the computer simulation results with the experimental outcomes. Nowadays the computer simulation is very well known, and it is based on the finite element method, what it makes possible to better comprehend the autonomy between the process parameters and selected optimal solution. The chance of applying faster and faster calculation machines and the formation of much software enables creating the more accurate models and more the adequate ones to reality.
Dimethyl-sulfoxide is a Suitable Solvent for Fluorescent Microscopy Detection of Medium and Strong Heat Shock Inductors Using Transgenic Zebrafish
Authors: Preluca Vlad , Serb Bogdan Horatiu , Marchian Sanda , Atasie Diter , Mitariu Mihaela Cernusca , Sabau Alexandru , Tantar Cristian , Sabau Dan
Published: February 2020

Heat shock inductors have potential as treatment for degenerative and protein misfolding diseases. Dimethyl-sulfoxide is widely used as a solvent in pharmacological screening tests and has been shown to have heat shock induction effects. Transgenic Tg (hsp70l:EGFP-HRAS_G12V)io3(AB) zebrafish larvae were exposed for 24 hours to dimethyl-sulfoxide in concentratios of 0.1-2%, and to moderate heat shock inductors pentoxifylline and tacrolimus. Positive controls were exposed to 35, 38 and 40�C for 20 min, and incubated for 24 h at 28�C. Heat shock response was measured by fluorescence microscopy and signal intensity quantification in FIJI. Dimethyl-sulfoxide caused a dose-dependant increase in fluorescent intensity, but significantly lower compared with exposure to 38 and 40�C. Pentoxifylline and tacrolimus induced a significantly higher increase in fluorescence compared with 0.5% dimethyl-sulfoxide. Thus, although dimethyl-sulfoxide has independent heat shock induction effects, concentrations of up to 0.5% are suitable for heat shock response screening tests.
The Effect of Permeability on Lignite Fly Ash Pneumatic Conveying System Design
Authors: Karlicic Nikola , Jovovic Aleksandar , Radic Dejan , Obradovic Marko , Todorovic Dusan , Stanojevic Miroslav
Published: February 2020

The aim of this experimental study was to evaluate the effect of permeability on the mode of flow that lignite fly ash will support in a pneumatic conveying pipeline. This research was initiated by recurring problems with the long distance and high capacity low grade lignite ash pneumatic conveying system at the 1200 MWe thermal power plant, such as clogging, unsteady flow mode, significant increase of velocity due to pressure drop and erosive wear of pipeline. Ash samples were taken during pneumatic conveying system clogging for further analysis. The experiment was limited to measuring parameters that provide data to determine minimum fluidizing velocity and permeability. The results showed very heterogeneous materials of group B by Geldart, what caused specific phenomenon during the experimental fluidization tests. Minimum fluidizing velocity for this kind of material is not authoritative for defining pneumatic conveying system, since extremely heterogeneous materials at this air speed will remain stationary or will convey very slow or with stoppage, and that required velocities are from 10 to 15 times higher than minimum fluidizing velocity. According to the results, this ash is the most suitable for dense phase pneumatic conveying.
The Use of Lugol Test in Determining the CSF Leaks Location of the Anterior Skull Base
Authors: Hainarosie Razvan , Meius Alexandru , Ionita Irina , Hainarosie Mura , Stefanescu Cristian Dragos , Zainea Viorel , Pietrosanu Catalina
Published: February 2020

Cerebrospinal fluid rhinorrhea is a rare medical problem but with increased mortality potential due to the risk of meningitis. This condition can be either traumatic or nontraumatic, based on the etiology. The traumatic CSF fistulas represent almost 80% of the entire CSF fistulas, surgical procedures cause nearly 16% of the CSF leaks in the anterior skull base, and the nontraumatic CSF leaks represent only 4%, and they are divided in normal-pressure and high-pressure fistulas. The diagnosis of CSF leaks is made by demonstrating the evidence of extracranial CSF. The diagnostic methods are double ring sign, glucose content of the nasal fluid, Beta-trace protein test, Beta2-transferrin test. To eliminate this risk of meningitis, when a CSF leak is discovered, the defect must be closed surgically. The challenge is to determine the exact location of the defect, mainly in cases of spontaneous CSF fistulas. The imagistic examination consists of CT scans and MRI tests. The gold standard for detecting CSF leakage is still intrathecal injection of fluorescein with endoscopic localization of the dural defect. This paper aims to analyze a staining test, using Lugol solution, to detect the location of the CSF fistula. The Lugol staining test that we proposed is quick, cheap, it does not produce a toxic reaction, excepting the Iodine allergic patients, and it can be used to detect the location of the skull base defect and the CSF leak.
Chemical Composition and Nutritional Evaluation of the Lupine Seeds (Lupinus albus L.) from Low-Alkaloid Varieties
Authors: Mierlita Daniel , Simeanu Daniel , Pop Ioan Mircea , Criste Florin , Pop Cecilia , Simeanu Cristina , Lup Florin
Published: February 2020

The aim of this paper is to analyse the chemical compositional and nutritional profiles of a two number of white lupine cultivars (Lupinus albus, cultivars Amiga and Energy) suited to the pedoclimatic conditions in Romania, collected in the year 2015. No significant differences were observed among lupine cultivars in their dry matter (DM), crude ash or alkaloid contents. The highest protein content (36.4�1.1% of DM) and crude fat (10.1�1.2% of DM) was found in seeds from lupines belonging to cv. Amiga, while the highest crude fibre content (15.2�1.7% of DM) was found in cv. Energy. Both varieties examined were characterised by a shortage of methionine and lysine, but lysine deficiency was higher in cv. Energy. Amiga cultivar was found to be a nutritionally more valuable crop than cv. Energy by the standards of nutrition for mature human and animals (chicken broilers and growing pigs). Amiga lupine was characterised by a higher essential amino acid index (EAAI) as well as chemical score (CS) of lysine, and the high nutritional index (NI) and biological value (BV) of protein as compared to cv. Energy. The white lupine seeds examined can serve as a source of good quality food protein for adult humans, meet the requirement for exogenous amino acids (EAA) and Lys in chicken broilers and to a lesser degree in the case of growing pigs, according to the standards of nutrition used. Fatty acid (FA) composition showed that oleic acid (C18:1 n-9) was the major fatty acid, followed by linoleic (C18:2 n-6) and linolenic (C18:3 n-3) acids. Apart from the highest level of polyunsaturated fatty acids (PUFA) the seed oil of Amiga cultivar showed and the largest content of linolenic acid (n-3) and the most favourable report n-3/n-6 FA.
QSAR Study of ORL1 Agonist Analgesic Effect of Some Imidazoles with Molecular Descriptors
Authors: Istratoaie Octavian , Rotaru Luciana Teodora , Varut Renata Maria , Varut Marius Ciprian , Fortofoiu Mircea Catalin , Fortofoiu Maria , Kostici Roxana
Published: February 2020

Imidazole and its derivates represent an interesting source of study for researchers for more than a century and was recently studied for their analgesic effect by ORL-1 receptor agonist effect on. In the theoretical study we used molecular mechanics programs and we characterized the structural properties for a series of ten imidazoles. The selected physico-chemical descriptors were: the HOMO and LUMO frontier orbitals, the dipole moment, the heat of formation, the total energy of the molecule, the ionization energy, the surface area and the molecular volume. From the correlation study we noticed the dependence between the analgesic effect and the total energy, the area of the molecular surface and the molecular volume.
Rapid Method for the Discrimination of Romanian Wines Based on Mid-Infrared Spectroscopy and Chemometrics
Authors: Topala Carmen Mihaela , Tataru Lavinia Diana
Published: February 2020

ATR-FTIR Spectroscopy combined with multivariate data analysis have been applied for the discrimination of 10 different Romanian wines (white and red wines), produced in 2 wineries from Romania: Reca� and Stefanesti-Arge�s from different cultivars. Principal Component Analysis were performed using different regions of FT-MIR spectra for all wines. Principal Component Analysis of their chemical parameters indicated that the wines can be discriminated based on their different phenolic, glucides, acidity content and geographical origin.
Chemical and Morphologic Analysis of Titanium Dental Implants: X-ray Photoemission Techniques (XPS) and Scanning Electron Microscopy (SEM) with EDX Analysis
Authors: Semez Gianfranco , Todea Carmen , Mocuta Daliana , Sas Ioana Tuta , Luca Ruxandra
Published: February 2020

Nowadays the implants rehabilitations are used deeply by clinicians. The importance to technological improvement is working to find the best surface of the fixture to obtain a good and stable osteointegration. By the use of the Energy Dispersive X-ray (EDX) analysis and the X-ray Photoemission Spectroscopy (XPS) evaluate the surface quality of commercial implants. The XPS analysis was made to evaluate the chemical elements that compose the material surface of the implant and determine the state of atomical connections. The EDX analysis was performed to evaluate the characteristic qualitative and quantitative of the metallic alloys of the fixtures to determinate the pureness of the metals under the surfaces. The major difference found between the samples is the amount of surface aluminum (in oxidized state, alumina), which in the samples 2 appears to be more than an order of magnitude greater (12 times). In Sample 2 there are traces of P, Na and Cl not present in Sample 1. The presence of C, O, N, Si and Ca are similar on both samples (1 and 2). Now, in the market there are many different dental implants. All the producers are working hard on micro and macro design of the fixtures, but not so many attentions is spent on the type of the alloy composing the implant. From this analysis, it is observed that different Type 4 dental implant are not so similar by composition. Moreover, the pure Titanium is well tolerated by biological tissues, on the other hand is not well known if the presence of other materials can influence the biological reaction. The samples of the fixture analyzed present different composition of the alloy, although both classified as Type 5 Titanium. Further studies on this topic are needed to understand if these differences of alloy composition can influence the clinical outcome.
Slow Pyrolysis of Cystoseira Barbata Brown Macroalgae
Authors: Cioroiu Doinita Roxana , Parvulescu Oana Cristina , Dobre Tanase , Raducanu Cristian , Koncsag Claudia Irina , Mocanu Alexandra , Duteanu Narcis
Published: February 2020

Slow pyrolysis of algal biomass of Cystoseira barbata was performed in a fixed bed reactor using carbon dioxide as a sweeping gas and a reactant in the process. Pyrolysis products consisted of a biochar, a bio-oil, and pyrolytic gases. According to a 23 factorial experiment, 8 tests were conducted for 1 hr at two levels of each process factor, i.e., specific heat flow rate (7540, 9215 W/m3), carbon dioxide superficial velocity (1.3, 2.6 cm/s), and bulk density of fixed bed biomass (221, 332 kg/m3). Correlations between these factors and final process responses in terms of mean bed temperature (461-663 oC), biochar yield (15.2-26.7%), bio-oil yield (29.9-34.8%), and BET surface area of biochar (45.17-91.12 m2/g) were established.
Effect of Sewage Sludge Amended Soil on Maize Crop I. Influence on yield and mineral nutrition
Authors: Ilie Leonard , Mihalache Mircea , Madjar Roxana Maria , Calin Catalina , Vasile Scaeteanu Gina
Published: February 2020

The aim of the present study was to evaluate the efficiency of sewage sludge application on maize (Zea Mays L.) growth, yield and macroelements accumulation (N, P, K, Ca, Mg) when different doses of sewage were applied accompanied by mineral fertilization. The results indicated that sewage sludge fertilization produces significant increase of maize yield that are evident starting with 200 kg N/ha rate, and the highest increases were recorded in the rate of 400 kg N/ ha. The nitrogen content in the maize leaves increased significantly in the variants fertilized with sludge at a rate over 300 kg N/ha, meanwhile the potassium content of the maize leaves was significantly reduced as a result of sludge fertilization at a rate equivalent to 400 kg N/ha. Nitrogen and phosphorus contents in the maize kernels increased with sewage sludge loading, meanwhile in the case of potassium the data showed that there were no statistically significant changes in the potassium content of the maize kernels under the influence of sewage sludge fertilization. The application of sewage sludge caused a significant increase of the calcium and magnesium contents in the maize leaves at equivalent rates higher than 200 kg/N ha.
Evolution of Tropospheric Ozone and Relationship with Temperature and NOx for the 2007-2016 Decade in the Ciuc Depression
Authors: Petres Sandor , Lanyi Szabolcs , Pirianu Marisanda , Keresztesi Agnes , Nechifor Aurelia Cristina
Published: February 2020

This paper presents the evolution of ozone concentration for the 2007-2016 decade and a comparison with key values related to human and vegetation health. As temperature is one of the main factors influencing ozone concentration in this area, the most significant changes of air temperature and extreme temperature indices for the 2007 - 2016 decade were evaluated, in retrospect to temperature measurements for the 1961-1990 reference period. The relationship between temperature and ozone concentration was also overviewed, by means of climate penalty factor. The influence of NOx concentration on ozone concentration was studied in order to compare the impact of climate changes with the impact of changes determined by anthropogenic emission.
Influence of Different Electroplating Sludge Types on the Iron Ions Recovery Yield
Authors: Marcus Maria Iuliana , Mitiu Mihaela Andreea , Vlad Maria , Mincu Mariana , Ghita Gina , Anghel Ana Maria
Published: February 2020

Electroplating sludge resulting from wastewater (washing wastewater and technological solutions) treatment is considered to be a hazardous waste, being a mixture of hydroxides of many heavy metals such us: iron, chromium, copper, nickel, cadmium or zinc. The metal compounds from electroplating sludge have a great economic value, thus, a number of techniques have been investigated in order to recover them. This paper presents the results of the research activity in the laboratory in order to recover Fe (II, III, VI) from two types of electroplating sludge: a fresh sludge from wastewaters treatment and an old sludge, stabilized by disposal for many years. Iron recovery was performed by the solubilization of the sludge in several stages, to yield hydroxides or metal salts of chromium, iron, or zinc. The iron recovery has been performed from the cake obtained after the chromium recovery. In this cake, the iron is present in the form of divalent, trivalent and hexavalent iron. The iron recovery yield was 98.50% from fresh sludge (recovery in one stage) and 96.80% from old sludge (recovery in two stages).
The Dtermination of Paracetamol by HPLC Validation of the Method and Application on Serum Samples
Authors: Ohriac (Popa) Viorica , Cimpoesu Diana , Spac Adrian Florin , Nedelea Paul , Lazureanu Voichita , Suciu Oana , Popa Tudor Ovidiu , Butnaru Elena
Published: February 2020

Pain is defined as a disagreeable sensory and emotional experience related to a tissue or potential lesion. Paracetamol (Acetaminophen) is the most used non-morphine analgesic. For the determination of paracetamol we developed and validated the high performance liquid chromatography (HPLC) analysis using a Dionex Ultimate 3000 liquid chromatograph equipped with a multidimensional detector. After determining the optimum conditions of analysis (80/20 water / acetonitrile mobile phase, flow rate 1.0 mL / min, detection wavelength 245 nm) we validated the method following the following parameters: linearity of response function, linearity of results, limit (LD = 0.66 mg / mL) and quantification limit (LQ = 2.00 mg / mL), and precision. The method of determining paracetamol by HPLC was applied to 30 samples of serum collected from patients who had pain and were treated with paracetamol.
Saliva as a Monitoring Fluid for Hormonal Activity in Systemic Lupus Erythematosus
Authors: Stanescu Iulia Ioana , Calenic Bogdan , Dima Alina , Miricescu Daniela , Badita Daniela Gabriela , Baicus Cristian , Balanescu Paul , Balanescu Eugenia , Perlea Paula , Greabu Maria
Published: February 2020

Saliva is a remarkable diagnostic fluid being used to monitor a wide range of local and systemic diseases. Autoimmune diseases represent a major health threat to women worldwide with sexual hormones acting as co-factors for these pathologies and interfering with the normal immune response. The main aim of our study was to evaluate salivary levels of testosterone (T2) and 17-b estradiol (E2) in several autoimmune diseases with a special focus on systemic lupus erythematosus (SLE). The study included 45 SLE patients, 15 patients with other autoimmune diseases and 10 healthy subjects. Salivary T2 and E2 levels were determined using ELISA assays. Salivary E2 levels in female SLE patients were significantly increased versus vasculitis female patients. Positive correlations have been found between salivary E2 levels and important clinical parameters such as age at inclusion and duration of corticosteroid treatment. E2 salivary level was also identified as an independent predictor of lupus renal nephritis. Regarding T2, salivary levels were found to be significantly lower in SLE female patients compared to respective controls. Furthermore, positive statistical correlations were found between T2 and E2 salivary levels. Collectively, these results promote the use of saliva as a monitoring fluid for hormonal activity in SLE.
Biochemical Markers of Hydronephrosis During Pregnancy
Authors: Negru Irina , Hinganu Delia , Hinganu Marius Valeriu , Pricop Catalin , Bulimar Virgil , Andronic Dan , Negru Dragos
Published: February 2020

Ureterohydronephrosis is a urological disease that can affect pregnant women in any trimester, but it also occur physiologically in the second trimester. The study included a group of 119 pregnant women diagnosed with ureterohydronephrosis. The diagnostic difficulties of the urological pathology in pregnancy are outweighed by the contribution of the biochemical assessment of patients, correlated with non-invasive imaging investigations. The results of the study highlight the peculiarities of these investigations in this group of patients and the possibilities of differential diagnosis.
The Impact of the Market Concentration Ratio on the Productivity Romanian chemical industry
Authors: Siminica Marian , Carstina Silviu Valentin , Circiumaru Daniel , Netoiu Lavinia
Published: February 2020

In this article we enlarge upon the market concentration ratio of all the companies in the chemical industry (divided into 16 areas of activity, according to the NACE code: The National Classification of Economic Activities), but also of the most important 50 companies in this sector, depending on the turnover. Throughout the paper, we deal with the correlation between the market concentration and profitability, determined by taking into consideration the net profit, ROA, ROE and the profit margin. The research results point to the existence of a weak correlation between the concentration ratio as an independent variable, and ROA and the profit margin as dependent variables. However, the correlation is direct and strong if connected to the net profit and ROE. For these two variables, there are patters of linear regression that have been brought together.
Vitamin D as a Regulator of Adipocyte Differentiation Effects in vivo and in vitro
Authors: Pinzariu Alin Constantin , Oboroceanu Teodor , Eloae Florin Zugun , Hristov Ioana , Costan Victor Vlad , Labusca Luminita , Cianga Petru , Verestiuc Liliana , Hanganu Bianca , Crauciuc Dragos Valentin , Manoilescu Irina Smaranda , Sindilar Eusebiu Viorel , Mocanu Veronica
Published: February 2020

The age-associated adiposity and the effect of long-term vitamin D was studied in vitamin D deficient rats. In in vivo experiments, the influence of a 9 months of vitamin D treatment (weekly oral gavage with 0.125 mg vitamin D3 (5000 IU)/100g body weight) on the adipocyte precursors from the omental adipose tissue was examinated. In in vitro experiment, rat adipose-derived mesenchymal stromal/stem cells (ASCs) were induced to differentiate into adipocytes in the presence or absence of 25(OH)D3 (0.25, 25, and 2500 nmol/L). ASCs derived from vitamin D-treated animals showed an increase adipogenic potential as compared to vitamin D-deficient rats. The addition of 25(OH)D3 inhibits the adipocyte differentiation and lipid deposition in a dose dependent manner.
Occurence of Characteristic Peaks in Phononic Multilayer Structures
Authors: Garus Sebastian , Szota Michal
Published: February 2020

In this paper the acoustic transmission properties of multilayer structures was analyzed. Were compared binary and aperiodic (Severin, Thue-Morse) superlattices, Calculations were performed using the Transfer Matrix Method (TMM) algorithm. As a superlattice environment in the simulation the water was used. The material used to construct the structure was a PNM-0.38PT piezoelectric. Multilayer types have been selected so that the total number of layers for a given generation is equal in all structures.
Chemical Composition Influence on Microhardness, Microstructure and Phase Morphology of AlxCrFeCoNi High Entropy Alloys
Authors: Geanta Victor , Voiculescu Ionelia , Milosan Ioan , Istrate Bogdan , Mates Ileana Mariana
Published: February 2020

The AlCrFeCoNi high entropy alloy exhibits unexpected properties that can be obtained after mixing five different elements, which could not be obtained from any one independent element. The difference to conventional alloys is that these alloys may have, at the same time, both hardness and plasticity, can be used in severe impact applications. In order to study the influence of aluminum content on the microhardness and microstructure of the high entropy alloys AlxCrFeCoNi (x: atomic ratio, x= 0.2 to 2.0) nine types of samples were obtained as mini-sized ingots (50x15x9.5 mm and 40 g weight). The mini-ingots were obtained using arc melt casting process in a vacuum arc remelting device (VAR MRF ABJ 900). The influence of the chemical elements on the microstructure, phases morphology and microhardness of AlxCrFeCoNi system was studied. The results have confirmed that mechanical properties could be greatly adjusted by the chemical composition change. The main element that influences the microhardness of the analyzed system is aluminum, due to the formation of Al-Fe compounds with high hardness. Increasing the aluminum content in the alloy to values greater than 1.8 ... 2 at.% contribute to the increase of hardness and also to the embrittlement thereof. Other elements like Cr, Fe, Co and Ni can contribute to mitigate increasing the hardness of the alloy. The type of phases formed in high entropy alloy are dependent to the aluminum concentration. So, depending on of aluminium content, different phases are obtained, like FCC for low Al content, mixture of FCC and BCC for about 2.5 %Al and BCC for high Al content. The crystallite size depends on the chemical composition and increase with the aluminium content.
Castleman�s Disease - Clinical, Histological and Therapeutic Features
Authors: Marcu Radu Dragos , Spinu Arsenie Dan , Socea Bogdan , Bodean Maria Oana , Diaconu Camelia Cristina , Vasilescu Florina , Neagu Tiberiu Paul , Bratu Ovidiu Gabriel
Published: February 2020

Castleman�s disease (CD) is a rare and benign lymphoproliferative pathology, characterized by lymphoid tissue hyperplasia, process that can occur at any site of the lymphoid chain. The purpose of this paper is to review the existing data regarding Castleman�s disease etiopathogenesis and treatment. Considering the extent of the lymphoid tissue involvement Castleman�s disease can be classified as unicentric (UCD) and multicentric (MCD). Another classification of this pathology is based on the histopathological features: hyaline vascular CD (90% of cases), plasma cell CD (less than 10%) and mixed cell type. Patients with UCD have good prognosis, the gold standard treatment being complete surgical excision. The multicentric type in contrast to UCD has a worse prognosis and associates the risk of evolving to lymphoma. Over the years different therapeutic strategies have been applied in the management of multicentric Castleman�s disease: glucocorticoids, chemotherapy, antiviral agents and monoclonal antibodies that target CD (cluster of differentiation) 20, interleukin -6 (IL-6) and IL-6 receptors. Castleman�s disease is a rare and complex pathology, whose etiopathogenesis is still incompletely elucidated. In the past few years the overall survival and progression free survival has significantly increased, due to different therapeutic options that have emerged, options that have constantly offered better and better results. Further investigation regarding the chemical interactions between different receptors and therapeutic molecules, understanding the mechanism of action and the potential benefits of each therapeutic agent may prove useful in clinical practice for treating CD.
Halogen Bonds of 4-Iodosydnones in Solution Deduced from 13C-NMR Spectra
Authors: Draghici Constantin , Caira Mino R. , Dumitrescu Denisa E. , Dumitrascu Florea
Published: February 2020

The ability of 4-iodosydnones to form halogen bonds with Lewis bases in solution was deduced from significant changes in the 13C-NMR chemical shift of the carbon atom of the sydnone ring which is bonded to iodine.
Gender Differences in the Association of Ferritin and 25-hydroxyvitamin D
Authors: Stoian Anca Pantea , Bala Cornelia , Rusu Adriana , Suceveanu Andra , Badiu Dumitru Cristinel , Nitipir Cornelia , Ditu Georgiana , Bica Cristina , Paduraru Dan Nicolae , Serafinceanu Cristian
Published: February 2020

This study aimed to investigate gender differences in the relationship between ferritin levels and 25(OH)vitamin D deficiency in overweight persons and whether this relationship is mediated by total and visceral adiposity and fatty liver index (FLI), a marker of non-alcoholic fatty liver disease.Our study was a retrospective one in which were collecting data from 92 patients seen in an outpatient clinical centre between January 2011 and October 2017. Patients were classified with vitamin D deficiency if 25(OH)vitamin D levels were [ 20.0 ng/mL. Univariate linear regression analysis assessed the association between ferritin levels and 25(OH)vitamin D deficiency, with and without correction for age, body composition (total fat mass and visceral fat mass) and FLI. In men, a statistically significant positive association between 25(OH)vitamin D deficiency and ferritin levels were found (b=0.424, p=0.008) in univariate and model adjusted for age. After adjustment for age and total fat mass and for age and visceral fat mass the association became non-significant in men (b=0.327, p=0.067 and b=0.295, p=0.106, respectively) and maintained non-significant after further adjustment for FLI (p [0.05). In women, ferritin level was negatively associated with 25(OH)vitamin deficiency in the model adjusted for age, visceral fat mass and FLI (b=-0.335, p=0.026). In this study, we showed that serum ferritin levels were negatively associated with the presence of 25(OH)vitamin D deficiency in women and this association was independent of age, body composition and FLI. No association was observed in men.
Coupled Catalytic/Gas Phase Ignition of Propane-Oxygen-Inert Mixtures on an Isothermally Heated Platinum Filament Supported on Quartz Bar
Authors: Mitu Maria , Razus Domnina , Oancea Dumitru
Published: February 2020

The ignition of gaseous flammable mixtures on catalytically active hot solid surfaces is an intricate process implying the tight interaction between surface and gas phase reactions. The paper presents the results obtained from the study of coupled catalytic-gas phase ignition of propane-oxygen-inert mixtures on an isothermally heated platinum filament stabilized on a thin quartz bar, measuring the induction periods, ti, rates of heat release, (dQr/dt)t and minimum ignition energies, Qmin. The experiments were conducted at different initial pressures between 73 and 101 kPa and filament temperatures between 1080 and 1184 K for 2.68% propane-air mixture and 4.02% propane-air mixture diluted with Ar or N2 in ratio 2:1. For any total pressure, the fuel concentration is the same in each mixture, the complementary composition containing the necessary oxygen for complete combustion and inerts or/and excess oxygen. The measured properties were rationalized using Arrhenius-type kinetic equations.
Characterization of Dyeing Techniques of Late 19th Century Ottoman-Style Costumes from the Jordanian Museum of Cultural Heritage
Authors: Sharairi Nidal Al , Sandu Irina Crina Anca
Published: February 2020

A collection of Ottoman-style costumes belongs to the late 19th century exhibited at the Jordanian Museum of Cultural Heritage were analyzed using SEM-EDX to identify types of fibres and mordants. The study aims to obtain more and comprehensive knowledge about these costumes completing a previous study that was carried out earlier to identify types of dyes applied. The article also attempts to establish an overview of the dyeing techniques used in late 19th century in the Middle East, specifically in the Levant region which was part of the Ottoman Empire at that time.
Spontaneous Remission of Retroperitoneal Fibrosis in a Patient with Inherited Thrombophilia
Authors: Puia Dragos , Radulescu Daniela , Gheorghinca Stefan , Turcu Flavia Liliana , Vacaroiu Ileana Adela , Pricop Catalin
Published: February 2020

Retroperitoneal fibrosis (RPF) is a rare condition characterized by a diffuse or localized fibroblastic proliferation associated with chronic inflammation. RPF is generally idiopathic, but can also be secondary to the use of certain drugs, malignant diseases, infections, and surgery. Treatment of RPF aims to relieve ureteral obstruction and to induce disease regression, and includes the use of steroids combined or not with other immunosuppressive agents. We present the case of a 35-years old female with a medical history of transient ischemic stroke, myocardial infarction, miscarriage and inherited thrombophilia, who was diagnosed in our Department with idiopathic RPF. Due to the mentioned associated comorbidities, no immuno-active treatment could be initiated. After one year, MRI exam showed significant spontaneous decrease of RPF mass. Although an uncommon event, the spontaneous resolution of idiopathic RPF could encourage in some selected cases a conservative management. By our knowledge, no previously cases of spontaneously remitted RPF in patients with inherited thrombophilia have been reported.
Antibiotic Molecules Efficacy in Pediatric Bacterial Infections
Authors: Chiriac Petronela Cristina , Poroch Vladimir , Pascu Alina Mihaela , Hogea Mircea Daniel , Antohe Ileana , Lupu Vasile Valeriu , Cirlig Valentin
Published: February 2020

The antibiotic resistance of microorganisms involved in pediatric infections represents a significant cause of healthcare-associated infections (HAIs), and is also a matter of management, requiring specific intervention. The aim of the study was to evaluate the efficacy of some antibiotic molecules on pathogens isolated from patients admitted in a pediatric hospital. We carried out a descriptive study on a group of 411 patients admitted to the Sf. MariaClinical Emergency Hospital for Children Iasi, between January 1st and March 31st, 2016. Bacterial infections were most prevalent in the age group of 0-1 year (54.98% of the total isolates). Most affected by multidrug-resistant bacterial infections services were: general pediatrics (24.08% of the total isolates), then the intensive care unit (19.95%), surgical wards (14.84%), and acute therapy (11.43%). The germs were isolated from pathological samples: most often pus (23.85%), hypo-pharyngeal aspiration (21.65%), conjunctival secretion (12.42%), and ear secretion (9.48%). Penicillin G and oxacillin were inefficient in 30.26% of the Staphylococcus aureus strains, while erythromycin in 18.42%. Antibiotic resistance of Streptococcus pneumoniae was observed for penicillin G in 7.14% of the strains, while for erythromycin in 13.09%. Klebsiella pneumoniae strains were resistant to amoxicillin + clavulanic acid in 35.85% of the cases, and to cefuroxime, ceftazidime, ceftriaxone, cefepime in 33.96%. Our study highlighted that Staphylococcus aureus was resistant to penicillin G and oxacillin in more than one-third of the isolates, Streptococcus pneumoniae was resistant to penicillin G and erythromycin, and Klebsiella pneumoniae to amoxicillin + clavulanic acid and 1st, 2nd and 3rd generation cephalosporins. Continuing antibioresistance monitoring is crucial in order to promote appropriate guidelines in antibiotic prescription, which could result in decreasing HAIs� rates.
Transformation of Gaseous Technical Mixture of the Alkanes and Alkenes Into Liquid Fraction Over Ni-HZSM-5 Obtained by Ionic Exchange
Authors: Asaftei Iuliean Vasile , Sandu Ion , Lungu Neculai Catalin , Spac Adrian Florin , Ignat Maria
Published: February 2020

Paraffin�s and olefins in the cracked naphtha can be transformed into aromatics and iso-paraffins to reduce the olefins content as well to improve the octane number of the gasoline commercial fraction. In this work Ni-HZSM-5 bifunctional catalyst was prepared by ion exchange with Ni(NO3)2 aqueous solution. The activity of Ni-HZSM-5 (wt.% 1.34% Ni) catalyst prepared by ion exchange method was investigated in the conversion of light hydrocarbons resulted as by-products of petroleum refining process (mixtures of butenes and (normal + iso) butanes as main components). The obtained Ni-based catalyst has been compare with HZSM-catalyst. The conversion experiments have been performed in a fixed-bed stainless-steel reactor (Twin Reactor System Naky) at 450oC, under 4 atm. (over Ni-HZSM-5) and 8 atm. pressure (over HZSM-5), respectively and at a space velocity (WHSV) of 1h-1. The catalytic activity of (Ni-HZSM-5 catalyst) monitored over 10 catalytic tests (with regeneration of catalyst after each test) using a mixtures butanes-butylenes. The catalytic activity and selectivity towards liquid products - BTX aromatic hydrocarbons and oligo(iC5-iC10, nC5-nC10, ] C10) - depends on time streaming, composition of butanes-butylenes mixture and pressure. In the first hours of each test the aromatic BTX are the main component of the liquid product (connected with butylenes consume) and after that, the oligo fraction become predominant. The initial aromatization process described as dehydrocyclodimerization of alkanes and alkenes, principally to aromatics BTX and molecular hydrogen, is accompanied by oligomerization, isomerization, cracking and alkylation processes to form finally in the liquid phase product an excessively mixture of iso- and normal - C5 -C10 and ] C10 aliphatic hydrocarbons.
Population Study on the Impact Food Chemical Composition on Patients with Non-Alcoholic Fatty Liver Diseases
Authors: Olteanu Andrei Vasile , Gilca Blanariu Georgiana Emmanuela , Balan Gheorghe Gh. , Mitrica Dana Elena , Gologan Elena , Timofte Oana , Toader Elena , Statescu Cristian , Diaconescu Smaranda , Stefanescu Gabriela
Published: February 2020

Non-alcoholic fatty liver disease (NAFLD) has become of major interest worldwide, it is estimated that more than 20% of the general population suffer from liver steatosis. NAFLD is highly associated with metabolic risk factors like type 2 diabetes mellitus, obesity and dyslipidemia, the patients diagnosed with NAFLD should adopt a high fiber low calorie diet, with reduced saturated fat and carbohydrates content, leading to weight loss and improvement of metabolic profile. Our study is aiming to shape the profile of the patient interested in being informed related to food quality and chemical composition and to evaluate the aspects on the food products label which are important for the customer. Between June 2017 and December 2017, 83 patients diagnosed with NASH were included in the study, representing the study group, while 33 subjects, without metabolic syndrome or digestive diseases, selected from patient list belonging to two general practitioners, constituted the control group. Related to the interest of being informed about the chemical composition and nutritional value of the products bought, the study showed a low interest for the provided information on nutritional value. lack of confidence in the provided information and complexity of the information are understandable, the high number of subject reasoning through lack of immediate clinical benefit is surprising. Among the healthy population the willingness to pay attention to this aspect is extremely low.