bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigating the effect of an online self-compassion for weight management (SC4WM) intervention on self-compassion, eating behaviour, physical activity and body weight in adults seeking to manage weight: protocol for a randomised controlled trial
Authors: Brenton-Peters Jennifer M , Consedine Nathan S , Cavadino Alana , Roy Rajshri , Serlachius Anna Sofia
Published: February 2022

Introduction

Individual weight management, defined as engaging in behaviours to maintain or lose weight, can improve health and well-being. However, numerous factors influence weight management outcomes, such as genetics, biology, stress, the social and physical environment. Consequently, weight management can be hard. Self-compassion, described as treating oneself kindly in times of failure or distress, has shown promise in improving weight management outcomes. The objectives of this study are twofold: (1) to examine the efficacy of an online self-compassion for weight management (SC4WM) intervention coupled with an online commercial weight management programme (WW Weight Watchers reimagined) with increasing self-compassion and improving weight management outcomes (eating behaviour, physical activity and body weight) in comparison with the WW programme only and (2) to explore whether improvements in weight management outcomes are moderated by eating restraint, weight self-stigma, perceived stress and psychological coping.

Methods and analysis

To achieve these objectives, 240 participants seeking to manage their weight were randomised to either an online behavioural commercial weight management programme (WW) or the online WW +SC4 WM intervention. Validated measures of self-compassion, stress, weight self-stigma, eating restraint, psychological coping and weight management outcomes were administered online at baseline, 4 weeks and at a 12-week follow-up.

Ethics and dissemination

Ethics has been granted by the University of Auckland Health Research Ethics committee. Results will be communicated in peer-review journals, conferences and a doctoral thesis. If effective in increasing self-compassion and improving weight management outcomes, the intervention could be made more widely available to supplement behavioural weight management programmes.

Trial registration number

ACTRN12621000580875; Pre-results.
Evaluation of gender differences in postoperative sore throat and hoarseness following the use of Ambu AuraGain laryngeal mask: the randomised controlled LadyLAMA trial study protocol
Authors: Epp Katharina , Przybylski Uli , Luz Carla , Kriege Marc , Wittenmeier Eva , Schmidtmann Irene , Pirlich Nina
Published: February 2022

Introduction

Postoperative sore throat (POST) is a comparatively minor but very common side effect of general anaesthesia with a supraglottic airway device. The patient considers these side effects a mirror of the quality of anaesthesia. The aims of this study are to evaluate gender-specific differences in the incidence of POST and to assess whether the effects of known risk factors vary between genders.

Methods and analysis

The LadyLAMA trial is a single-centre, patient-blinded, randomised controlled trial. Consecutive patients requiring ophthalmological surgery under general anaesthesia with a second generation Ambu AuraGain laryngeal mask are randomly allocated to either cuff pressure of 45 cmH2O or cuff pressure of 60 cmH2O. We estimate the difference in POST between the genders at 20% and we hypothesised that a reduction of cuff pressure would reduce POST by 10%. A total of 800 patients will be recruited, with each subgroup including 200 patients to achieve 80% power for detecting a difference at the 5% significance level. Primary endpoints are gender differences in the incidence of POST within 24 hours postoperatively, as well as comparison of cuff pressure 45 cmH2O to 60 cmH2O with respect to POST. The main secondary objective is the effect of cuff pressure on POST stratified by gender. Further secondary endpoints are gender-specific differences in POST and hoarseness in postanaesthesia care unit (PACU) at 48 and 72 hours (or until freedom of discomfort). The parameter cuff pressure serves as key-secondary endpoint.

Ethics and dissemination

The project is approved by the local ethics committee of the Medical Association of the Rhineland Palatine state (Nr. 2021-15835). The results of this study will be made available in the form of manuscripts for publication and presentations at national and international meetings.

Trial registration number

NCT04915534.
Ultrasound measurements of pathological and physiological skin thickness: a scoping review protocol
Authors: Meikle Brandon , Kimble Roy M , Tyack Zephanie
Published: February 2022

Introduction

Ultrasound is a quick, safe, and non-invasive imaging method that can be used to measure skin thickness in pathological cutaneous conditions in clinical and research settings. Despite widespread use, there exists a lack of standardisation and reporting of ultrasound skin thickness measurement methods, which makes between-studies comparisons difficult. To address this, we present a scoping review protocol, which aims to determine what is and is not known about the measurement of skin and scar thickness using ultrasound in people with traumatic scars.

Methods and analysis

The Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews guidelines and Joanna Briggs Institute scoping review methodology will be used to guide this review. Electronic database searching will be conducted in Ovid MEDLINE, Embase, Cumulative Index of Nursing and Allied Health Literature and Web of Science. No date limit will be imposed on the database searches. Records will be supplemented with searches of reference lists of included studies and grey literature in OpenGrey and Google Advanced. Screening will be conducted by two independent reviewers, and studies where ultrasound is used to measure skin and scar thickness in people with traumatic scars will be included. Data extraction will include ultrasound methods (eg, transducer orientation), psychometric properties (eg, reliability, measurement error), health service and implementation outcomes (eg, feasibility, acceptability) and factors influencing ultrasound measurement of skin thickness (eg, body location, age).

Ethics and dissemination

Ethical approval is not required for this investigation, as published literature will form the basis of the review. The review will be published in a peer-reviewed scientific journal and is expected to result in the development of the first evidence-based and consensus-based methodological guideline for skin thickness measurement by ultrasound.
Development and use of research vignettes to collect qualitative data from healthcare professionals: a scoping review
Authors: Tremblay Dominique , Turcotte Annie , Touati Nassera , Poder Thomas G , Kilpatrick Kelley , Bilodeau Karine , Roy Mathieu , Richard Patrick O , Lessard Sylvie , Giordano Émilie
Published: February 2022

Objectives

To clarify the definition of vignette-based methodology in qualitative research and to identify key elements underpinning its development and utilisation in qualitative empirical studies involving healthcare professionals.

Design

Scoping review according to the Joanna Briggs Institute framework and Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews guidelines.

Data sources

Electronic databases: Academic Search Complete, CINAHL Plus, MEDLINE, PsycINFO and SocINDEX (January 2000–December 2020).

Eligibility criteria

Empirical studies in English or French with a qualitative design including an explicit methodological description of the development and/or use of vignettes to collect qualitative data from healthcare professionals. Titles and abstracts were screened, and full text was reviewed by pairs of researchers according to inclusion/exclusion criteria.

Data extraction and synthesis

Data extraction included study characteristics, definition, development and utilisation of a vignette, as well as strengths, limitations and recommendations from authors of the included articles. Systematic qualitative thematic analysis was performed, followed by data matrices to display the findings according to the scoping review questions.

Results

Ten articles were included. An explicit definition of vignettes was provided in only half the studies. Variations of the development process (steps, expert consultation and pretesting), data collection and analysis demonstrate opportunities for improvement in rigour and transparency of the whole research process. Most studies failed to address quality criteria of the wider qualitative design and to discuss study limitations.

Conclusions

Vignette-based studies in qualitative research appear promising to deepen our understanding of sensitive and challenging situations lived by healthcare professionals. However, vignettes require conceptual clarification and robust methodological guidance so that researchers can systematically plan their study. Focusing on quality criteria of qualitative design can produce stronger evidence around measures that may help healthcare professionals reflect on and learn to cope with adversity.
Vitamin K-dependent anticoagulant use and level of anticoagulation control in sub-Saharan Africa: protocol for a retrospective cohort study
Authors: Mwita Julius Chacha , Damasceno Albertino , Chillo Pilly , Ogah Okechukwu S , Cohen Karen , Oyekunle Anthony , Tefera Endale , Francis Joel Msafiri
Published: February 2022

Background

Given that vitamin K-dependent anticoagulants (VKAs) will continue to be the primary anticoagulant in Africa for a long time, understanding the quality of anticoagulation services in the continent is vital for optimising the intended benefits. Notably, a few small studies have assessed the quality of anticoagulation in sub-Saharan Africa (SSA) countries. This study will describe the current VKA use and anticoagulation control among patients in selected SSA countries.

Methods and analysis

We plan to review the 2019 anticoagulation data of a cohort of 800 random patients from 19 selected clinics in Botswana, the Democratic Republic of Congo, Ethiopia, Gambia, Ghana, Mozambique, Nigeria, Tanzania and South Africa. We expect at least one participating site to enrol 100 participants in each country. Eligible participants will be those on VKAs for at least 3 months and with at least four international normalised ratio (INR) results. We will document the indications, type and duration of VKA use, sociodemographic factors, coexisting medical conditions, concurrent use of drugs that interact with warfarin and alcohol and tobacco products. The level of anticoagulation control will be determined by calculating the time-in-therapeutic range (TTR) using the Rosendaal and the Percent of INR in TTR methods. A TTR of less than 65% will define a suboptimal anticoagulation control.

Ethics and dissemination

This study was approved by the Ministry of Health and Wellness Ethics Committee (HPDME13/8/1) in Botswana and local research ethics committees or institutional review boards of all participating sites. As the study collects data from existing records, sites applied for waivers of consent. We will disseminate research findings through peer-reviewed scientific publications.
Improving delivery of low tidal volume ventilation in 10 ICUs
Authors: Donadee Chenell , Cohen-Melamed Mark , Delgado Edgar , Gunn Scott R
Published: February 2022

Low tidal volume ventilation (LTVV) is standard of care for mechanically ventilated patients with acute respiratory distress syndrome and has been shown to improve outcomes in the general mechanically ventilated population. Despite these improved outcomes, in clinical practice the LTVV standard of care is often not met. We aimed to increase compliance with LTVV in mechanically ventilated patients in 10 intensive care units at 3 hospitals within the University of Pittsburgh School of Medicine Department of Critical Care Medicine. Four Plan-Do-Study-Act (PDSA) cycles were implemented to improve compliance with LTVV. Initial compliance rates of 40.6%–60.1% improved to 91%–96% by the end of the fourth PDSA cycle. The most impactful step in the intervention was providing education and giving responsibility of selecting the tidal volume to the respiratory therapist. The overall intervention resulted in improved compliance with LTVV that has been sustained for multiple years after our active PDSA cycles.
Advance and future care planning: strategic approaches in Wales
Authors: Taubert Mark , Bounds Lauren
Published: February 2022

Background

In Wales, the term advance care planning now falls under the wider umbrella term ‘Future Care Planning’, which also includes patients with diminished mental capacity and their significant others, to engage in deciding and planning future care. Over the last 5 years, work has been undertaken to create education formats, resources and national documents, and this has been informed by a national Advance and Future Care Planning steering group and national conference, which included patient and carer representatives. This helped collate relevant data.

Aim

We outline key strategic approaches in Wales with regard to future care planning.

Results

With data from our national conference and through feedback from stakeholders, a national repository of distinct resources, forms and education formats has been created. The approach seeks to cater for the disparate need of the Welsh population; there is not merely one format for multiple scenarios, but a choice of approaches, communication strategies and documents to suit bespoke needs.

Conclusion

Advance and future care planning is an approach with many different facets. In Wales, we have found that some patients prefer a clearly set out, legally binding ‘Advance Decision to Refuse Treatment’ to guide their care, while others prefer a softer, guiding approach captured through an Advance Statement. All these formats are available to patients, carers and healthcare professionals, together with explanatory guidance notes, through a central Welsh website. Next steps involve getting a central electronic repository for these forms, which is accessible to healthcare providers and to patients.
Towards understanding specific ion effects in aqueous media using thermodiffusion
Authors: Mohanakumar Shilpa , Wiegand Simone
Published: February 2022

Specific ion effects play an important role in scientific and technological processes. According to Hofmeister, the influence on the hydrogen bond network depends on the ion and leads to a specific order of the ions. Also thermodiffusion the mass transport caused by a temperature gradient is very sensitive to changes of the hydrogen bond network leading to a ranking according to hydrophilicity of the salt. Hence, we investigate various salt solutions in order to compare with the Hofmeister concept. We have studied three different sodium salts in water as a function of temperature (25–45$$^\circ $$

∘

C) and concentration (0.5–5 mol kg$$^{-1}$$

-
1

) using Thermal Diffusion Forced Rayleigh Scattering (TDFRS). The three anions studied, carbonate, acetate and thiocyanate, span the entire range of the Hofmeister series from hydrophilic to hydrophobic. We compare the results with the recent measurements of the corresponding potassium salts to see to what extent the cation changes the thermodiffusion of the salt.

Graphic abstract
The Ediacaran origin of Ecdysozoa: integrating fossil and phylogenomic data
Authors: Howard Richard J. , Giacomelli Mattia , Lozano-Fernandez Jesus , Edgecombe Gregory D. , Fleming James F. , Kristensen Reinhardt M. , Ma Xiaoya , Olesen Jørgen , Sørensen Martin V. , Thomsen Philip F. , Wills Matthew A. , Donoghue Philip C. J. , Pisani Davide
Published: February 2022

Ecdysozoans (Phyla Arthropoda, Kinorhyncha, Loricifera, Nematoda, Nematomorpha, Onychophora, Priapulida, Tardigrada) are invertebrates bearing a tough, periodically moulted cuticle that predisposes them to exceptional preservation. Ecdysozoans dominate the oldest exceptionally preserved bilaterian animal biotas in the early to mid-Cambrian (
c.
520–508 Ma), with possible trace fossils in the latest Ediacaran (<556 Ma). The fossil record of Ecdysozoa is among the best understood of major animal clades and is believed to document their origins and evolutionary history well. Strikingly, however, molecular clock analyses have implied a considerably deeper Precambrian origin for Ecdysozoa, much older than their earliest fossils. Here, using an improved set of fossil calibrations, we performed Bayesian analyses to estimate an evolutionary time-tree for Ecdysozoa, sampling all eight phyla for the first time. Our results recover Scalidophora as the sister group to Nematoida + Panarthropoda (= Cryptovermes nov.) and suggest that the Ediacaran divergence of Ecdysozoa occurred at least 23 myr before the first potential ecdysozoan trace fossils. This finding is impervious to the use of all plausible phylogenies, fossil prior distributions, evolutionary rate models and matrix partitioning strategies. Arthropods exhibit more precision and less incongruence between fossil- and clock-based estimates of clade ages than other ecdysozoan phyla.

Supplementary material:
Full methodologies used and an appendix of fossil calibration points are available at
https://doi.org/10.6084/m9.figshare.c.5811381

Thematic collection:
This article is part of the Advances in the Cambrian Explosion collection available at:
https://www.lyellcollection.org/cc/advances-cambrian-explosion
A Systematic Analysis on the Impact of Contextual Information on Point-of-Interest Recommendation
Authors: Rahmani Hossein A. , Aliannejadi Mohammad , Baratchi Mitra , Crestani Fabio
Published: February 2022

As the popularity of Location-based Social Networks increases, designing accurate models for Point-of-Interest (POI) recommendation receives more attention. POI recommendation is often performed by incorporating contextual information into previously designed recommendation algorithms. Some of the major contextual information that has been considered in POI recommendation are the location attributes (i.e., exact coordinates of a location, category, and check-in time), the user attributes (i.e., comments, reviews, tips, and check-in made to the locations), and other information, such as the distance of the POI from user’s main activity location and the social tie between users. The right selection of such factors can significantly impact the performance of the POI recommendation. However, previous research does not consider the impact of the combination of these different factors. In this article, we propose different contextual models and analyze the fusion of different major contextual information in POI recommendation. The major contributions of this article are as follows: (i) providing an extensive survey of context-aware location recommendation; (ii) quantifying and analyzing the impact of different contextual information (e.g., social, temporal, spatial, and categorical) in the POI recommendation on available baselines and two new linear and non-linear models, which can incorporate all the major contextual information into a single recommendation model; and (iii) evaluating the considered models using two well-known real-world datasets. Our results indicate that while modeling geographical and temporal influences can improve recommendation quality, fusing all other contextual information into a recommendation model is not always the best strategy.
Maltol Promotes Mitophagy and Inhibits Oxidative Stress via the Nrf2/PINK1/Parkin Pathway after Spinal Cord Injury
Authors: Mao Yuqin , Du Jiqing , Chen Xianghang , Al Mamun Abdullah , Cao Lin , Yang Yanhong , Mubwandarikwa Joana , Zaeem Muhammad , Zhang Wanying , Chen Yan , Dai Yusen , Xiao Jian , Ye Keyong
Published: February 2022

Spinal cord injury (SCI), a fatal disease in the central nervous system, is characteristic of weak neuronal regeneration ability and complex pathological progress. Activation of oxidative stress (OS) and apoptosis-mediated cell death significantly contributes to the progression of SCI. Current evidence suggests that maltol exerts natural antioxidative properties via obstructing OS and apoptosis. However, the significant effect of maltol on SCI treatment has never been evaluated yet. In our current study, we explored maltol administration that could trigger the expression of Nrf2 and promote the retranslocation of Nrf2 from the cytosol to the nucleus, which can subsequently obstruct OS signal and apoptosis-mediated neuronal cell death after SCI. Furthermore, we found that maltol treatment enhances PINK1/Parkin-mediated mitophagy in PC12 cells, facilitating the recovery of mitochondrial functions. Our findings propose that maltol could be a promising therapeutic candidate for the treatment and management of SCI.
Convolutional Neural Network in Evaluation of Radiotherapy Effect for Nasopharyngeal Carcinoma
Authors: Qian Haifeng , Fang Yancheng
Published: February 2022

This study was aimed to explore the adoption value of magnetic resonance imaging (MRI) under convolutional neural networks (CNN) in the therapeutic effect of nasopharyngeal carcinoma (NPC) radiotherapy. A total of 54 NPC patients were recruited. CNN was employed to perform 3D visualization processing on magnetic resonance (MR) images of NPC patients. MRI changes were analyzed before and after the patient received radiotherapy. The image segmentation and radiotherapy effects of CNN were evaluated by the Recall, intersection over union (IOU), postoperative apparent diffusion coefficient (ADC), and diagnostic coincidence rate. Moreover, gradient vector flow (GVF) algorithm, fuzzy c-means (FCM), and SegNet were adopted for comparative evaluation. Recall of CNN was 94.89% and the IOU was 84.16%, which was remarkably different from other algorithms (P < 0.05). After analysis of the MRI images of patients receiving radiotherapy, ADC of local residual patients was 1.108 ± 0.097 measured by CNN, the ADC was 1.826 ± 0.115, and the missed diagnosis rate was only 7.14%. In summary, CNN had a good effect on the localization and segmentation of NPC patients, and can accurately evaluate the effect of patients receiving radiotherapy, which can assist clinical diagnosis and treatment of NPC.
[Retracted] Radiosensitizing Effect of Celastrol by Inhibiting G2/M Phase Arrest Induced by the c‐myc Gene of Human SW1353 Chondrosarcoma Cells: Network and Experimental Analyses
Authors: Qian Jin , Zhang Zhen , Han Xiao , Zhu Liulong , Bian Zhenyu , Xie Tao
Published: February 2022

Objective. Studies have unveiled that the components of Tripterygium wilfordii Hook F (TWHF) such as celastrol could attenuate apoptosis and proliferation of various tumor cells. This study is focused on the radiosensitization effect and apoptotic pathways of celastrol via the inhibition of the c-myc gene and the influence of which combined with radiotherapy on the proliferation, apoptosis, invasion, and metastasis of chondrosarcoma cells. Methods. A variety of bioinformatic tools were applied to explore the expression level and prognosis of the c-myc gene in different tumor cells and chondrosarcoma cells. We used pharmacology network to analyze the components, pathways, targets, molecular functions of TWHF and explore the relevant effective components over the MYC gene. Clone formation assay, CCK‐8 assay, flow cytometry, and transwell migration assay were applied to detect the effects of celastrol on the expression of c-myc gene, cell apoptosis, and cell cycle. Radiation therapy was used to observe the radiosensitization effect of celastrol on chondrosarcoma. Results. This study shows that the c‐myc gene is overexpressed in various tumor cells and bone tumor cells to varying degrees. Celastrol can significantly inhibit the expression of the c-myc gene, induce G2/M phase arrest through regulation of G2/M phase‐related proteins, and promote SW1353 cell apoptosis through the mitochondrial signaling pathway. In addition, we also found that the use of triptorubin to inhibit c-myc gene expression in combination with radiotherapy can increase the osteosarcoma cells’ apoptosis rate through the mitochondrial signaling pathway significantly. Conclusions. Our study validated the radiosensitization effect of celastrol through knocking down the expression of the c‐myc gene to induce G2/M phase arrest and provides a new idea for the treatment of refractory or recurrent chondrosarcoma that is not sensitive to radiotherapy.
Research on Risk Prediction Model of Internet Finance Based on Cloud Computing
Authors: Li Shuanbao , Liu Xiaoyan , Li Chengfei
Published: January 2022

With the rapid development of the Internet, the traditional Internet financial risk prediction methods can no longer meet the needs of individuals and enterprises, so the concept of cloud computing arises at the historic moment. Cloud computing has subverted the traditional financial risk prediction method and has been widely studied and applied for its distributed, dynamic and autonomous characteristics. How to efficiently and reasonably schedule the resources of cloud data center and improve the accuracy of financial risk prediction is the focus of current research. How to quantify financial risk and financial risk early warning is one of the urgent problems to be solved. Under the framework of cloud computing, this paper combines the feature extraction and data weighting to study the user’s basic attribute data and a large number of downloaded APP types. After that, linear regression with penalty is used to construct the prediction model to improve insolvency. The accuracy of customer default judgment can realize local optimization, so as to improve the prediction and control of hidden risks of customer commercial bank loans and greatly reduce the default risk of bank loans.
FOXM1 Promotes Drug Resistance in Cervical Cancer Cells by Regulating ABCC5 Gene Transcription
Authors: Hou Youxiang , Dong Zhanfei , Zhong Wei , Yin Linglong , Li Xiong , Kuerban Gulina , Huang He
Published: February 2022

Objective. The aim of the present study was to investigate the effect of forkhead box M1 (FOXM1) to paclitaxel resistance in cervical cancer cells, to determine the underlying mechanism, and to identify novel targets for the treatment of paclitaxel‐resistant cervical cancer. Methods. Paclitaxel‐resistant Caski cells (Caski/Taxol cells) were established by intermittently exposing the Caski cells to gradually increasing concentrations of paclitaxel. The association between FOXM1, ATP‐binding cassette subfamily C member 5 (ABCC5), and cervical cancer cell drug resistance was assessed by overexpressing or knocking down the expression of FOXM1 in Caski or Caski/Taxol cells. The protein and mRNA expression levels, the ratio of cellular apoptosis, and cell migration as well as intracellular drug concentrations were measured in cells following the different treatments. Results. After the successful establishment of resistant Caski/Taxol cells, cell cycle distribution analysis showed that a significantly larger percentage of Caski/Taxol cells was in the G0/G1 stage compared with the Caski cells (P < 0.01), whereas a significantly larger percentage of Caski cells was in the S and G2/M stage compared with the Caski/Taxol cells following treatment with paclitaxel (P < 0.01). Both the protein and mRNA expression levels of FOXM1 and ABCC5 transporters were significantly higher in the paclitaxel‐resistant Caski/Taxol cells compared with Caski cells (P < 0.05). Knockdown of FOXM1 significantly lowered the protein expression levels of FOXM1 and ABCC5. Intracellular paclitaxel concentrations were significantly higher amongst the Caski/Taxol cells following the knockdown of FOXM1 by shRNA or Siomycin A (P < 0.05). Conclusion. FOXM1 promotes drug resistance in cervical cancer cells by regulating ABCC5 gene transcription. The knockdown of FOXM1 with shRNA or Siomycin A promotes paclitaxel‐induced cell death by regulating ABCC5 gene transcription.
Application of a New Feature Generation Algorithm in Intrusion Detection System
Authors: Niu Yingchun , Chen Chengdong , Zhang Xuehua , Zhou Xiaoguang , Liu Hongjie
Published: February 2022

The intrusion detection system is designed to discover the abnormal behavior of the network system, but it has the problems of low detection accuracy, inability to perform fine detection, and huge time cost. Therefore, it is necessary to design a fast and accurate intrusion detection system. Therefore, this paper proposes a multigranularity feature generation + XGBOOST method to improve the intrusion detection system. First, we propose a multigranularity feature generation algorithm, which converts all features into discrete features with different numbers of categories. Different numbers of categories represent different granularities. We believe that the combination of multiple different granular features can achieve better accurate attack detection. Then, we use the proposed method to perform experimental verification on the four datasets of KDD99, NSL-KDD, UNSW_NB15, and CSE-CIC-IDS2018. For the KDD99 dataset, detection rates of 100%, 100%, and 99.43% can be achieved in the two-category, five-category, and multicategory tasks, respectively; for the NSL-KDD dataset, detection rates of 100%, 100%, and 90.84% can be achieved in the two-category, five-category, and multicategory tasks, respectively; for the UNSW_NB15 dataset, 100% detection rate can be achieved in the second and tenth categories; for the CSE-CIC-IDS2018 dataset, 100% detection rate can be achieved in the third classification. Experiments show that the proposed algorithm can achieve accurate and precise detection. Finally, we experiment with the multigranularity feature generation algorithm on multiple classifiers and multiple datasets to prove the generalization ability of the proposed feature generation algorithm and compare the proposed algorithm with the CFS algorithm to prove the efficiency of the algorithm.
Evolutionary Game of Social Network for Emergency Mobilization (SNEM) of Magnitude Emergencies: Evidence from China
Authors: Nan Rui , Wang Jingjie , Zhu Wenjun
Published: January 2022

As a common social network, the SNEM plays an important role in emergency management. Magnitude emergencies are characterized by high complexity and uncertainty, and it is impossible to rely on the government for emergency management alone. We should absorb multiple subjects to build the SNEM and carry out extensive emergency mobilization in the whole society. The SNEM can integrate resources, gather consensus, promote participation, and reduce risks. The analysis of the types, generation mechanism, subject behavior, and strategy selection of the SNEM aid in adopting appropriate mobilization strategy based on magnitude emergencies, achieving the adaptation of the SNEM and emergency scenarios. By constructing the evolutionary game model of the SNEM for magnitude emergencies, taking China as an empirical sample, this paper explores the behavior evolution law and stable strategy of the government, social organizations, and the public. The results showed that the symbiotic SNEM with a positive response of social organizations and the public under the path of high‐intensity mobilization by the government is the best strategy combination, and it is conducive to maximizing the emergency joint force.
Regional Tourism Economic Impact Evaluation Based on Dynamic Input‐Output Model
Authors: Cao Ruili
Published: February 2022

The level of inbound tourism development is an important criterion to measure the internationalization of tourism, which is an important factor representing the tourism economy. Taking Anhui province as the research object, the inbound tourism development efficiency of 16 cities in Anhui province from 2011 to 2019 is analyzed with the help of the DEA model and Malmquist index, and the key factors affecting the inbound tourism development efficiency are analyzed with the OLS model. It is found that (1) the overall development of inbound tourism in Anhui province is in a high state, but there are still phenomena such as waste of resources, overexploitation, and unreasonable industrial investment, which lead to the unbalanced and insufficient development of regional inbound tourism. (2) Inbound tourism efficiency in Anhui province is influenced by the level of economic development, tourism resource endowment, accessibility, and the scale of human resources, suggesting that inbound tourism is essentially natural resource, infrastructure, and service facility driven. The study is important to clarify the path of improving the efficiency of inbound tourism, promote the development of high‐quality inbound tourism, and thus achieve high‐quality transformation of tourism.
Effects of Adiponectin on Glucose Metabolism in the Hepatopancreas of Grass Carp (Ctenopharyngodon idella)
Authors: Qin Chaobin , Zhao Wenli , Yan Xiao , Yang Guokun , Yang Liping , Lu Ronghua , Pi Daming , Nie Guoxing
Published: February 2022

Adiponectin plays critical roles in the regulation of energy metabolism in mammals. However, its roles in fish remain to be evaluated. In this study, we examined the tissue distribution characteristics of two adiponectin genes, namely, adipoqa and adipoqb, at transcriptional level, and detected the changes of their mRNA expressions during oral glucose tolerance test (OGTT). Furthermore, we prepared recombinant proteins of grass carp adiponectin A and adiponectin B and studied their roles in the regulation of glucose metabolism in the hepatopancreas of grass carp in vivo. The results showed that adipoqa mRNA was mainly expressed in the heart of grass carp, followed by red muscle, white muscle, and adipose tissue, while adipoqb mRNA was highly expressed in adipose tissue, red muscle, and white muscle. The mRNA levels of adipoqa and adipoqb in the white muscle and heart were significantly decreased at 1 h post OGTT, and their expressions in the heart were also suppressed at 3 h, whereas the transcriptional levels of adipoqa and adipoqb in the red muscle were elevated significantly at 12 h after glucose load. Intraperitoneal injection of adiponectin A or adiponectin B reduced basal serum glucose levels of grass carp and caused an increase of glycogen content in the hepatopancreas. Adiponectin A upregulated the expression of enzyme genes related to glycolysis (gk and pk) and glycogen synthesis (gys) in the hepatopancreas, and adiponectin B promoted the expression of pk and gys, as well as g6pase in the glycogenetic pathway. Besides, adiponectin A and adiponectin B have opposite regulatory effects on glut2 mRNA expression. These results suggested that adiponectin A and adiponectin B promoted glycolysis, gluconeogenesis, and glycogen synthesis, increased glycogen content of hepatopancreas, and reduced basal blood glucose level, and they may have an antagonistic regulatory mechanism in regulating glucose uptake.
Financial Derivative Price Forecasting and Trading for Multiple Time Horizons with Deep Long Short-Term Memory Networks
Authors: Liu Bingru , Zhao Qing
Published: February 2022

Price forecasting and trading in the international crude oil market are important issues for investors in energy finance. In this study, we propose an alternative forecasting approach for financial derivative price multiple days ahead and simulated trading based on long short-term memory (LSTM). This study aims to evaluate for different multiple days ahead forecasting and trading by deep LSTM-based model using technical analytic features, which have nonlinear behaviors. The effectiveness of LSTM networks trained by backpropagation through time for test objective prediction is explored. Moreover, instead of using only one crude oil market's spot price data as a data source, we build up a crude oil database with the two most important crude oil markets. The results indicate that the proposed approach outperforms others in terms of accuracy, return, and risk aspect. The forecasting and holding (for trade) time horizons are 1–3 days ahead, respectively. For all three multiple days ahead forecasting and trading, the average test accuracy (judged by root mean square error) of two crude oil markets for four datasets of deep LSTM-based model yields best results among all methods. This study also developed trading strategies, and the proposed LSTM-based method also outperforms other benchmark methods on both return and return-risk ratio (judged by Sharpe ratio). The experimental results indicate that the proposed method can help traders make profits in the financial derivative market and is more effective than the state-of-the-art methods in actual trading.
Safflower Promotes the Immune Functions of the Common Carp (Cyprinus carpio L.) by Producing the Short-Chain Fatty Acids and Regulating the Intestinal Microflora
Authors: Meng Xiaolin , Li Heng , Yang Guokun , Zhang Yanmin , Cao Hui , Hu Wenpan , Zhang Xindang , Zhang Jianxin , Li Keke , Chang Xulu
Published: February 2022

To evaluate the functions of safflower on aquatic animal, the effects of dietary safflower supplementation on growth performance, immunity response, short-chain fatty acids, and intestinal microflora of common carp (Cyprinus carpio L.) were studied in the present study. Four isonitrogen and isolipid experimental diets were formulated by adding 0, 0.25%, 0.50%, and 1.00% safflower to the basal diet (CON, S-0.25%, S-0.50%, and S-1.00%, respectively). The results showed that safflower supplementation (S-0.50%) significantly improves the growth performance (FBW, WGR, SGR) compared with that of the CON group (

P
<
0.05

). Similarly, safflower also promoted the CAT and LZM activities in the midgut, yet the content of MDA in the S-0.50% group was reduced (

P
<
0.05

). The content of proinflammatory factors (IL-1β, IL-12) in serum underwent significant reduction (

P
<
0.05

); the level of anti-inflammatory factor IL-10 had an upward trend in the S-0.50% group. Moreover, the mRNA expression levels of the IL-10, TGF-β, NF-κB, and TLR-1 gene in the head kidney were remarkably upregulated (

P
<
0.05

) in safflower addition groups, while IL-6 and IL-1β were downregulated significantly in the S-1.00% group (

P
<
0.05

). After 96 hours of the A. hydrophila challenge test, the survival rate of common carp had been improved greatly with the safflower addition, which was most impressive in the S-1.00% group. Additionally, the levels of acetic acid and butyric acid in intestinal contents were significantly higher in the S-0.50% and S-1.00% groups than in the CON group (

P
<
0.05

). Dietary safflower increased the intestinal microbiota abundance of Fusobacteria at the phylum level. At the genus level, the abundance of beneficial bacteria (Lactobacillus and Bifidobacterium) increased significantly in the S-1.00% group; some pathogens such as Aeromonas, Shigella, and Streptococcus were inhibited. Spearman coefficient analysis revealed that the contents of SCFAs were positively correlated with probiotics and negatively correlated with pathogens. In summary, safflower addition at an appropriate dose can promote the immune functions of the common carp by producing the short-chain fatty acids and regulating the intestinal microflora.
Risk Factor Analysis and Construction of a Prognostic Model after Percutaneous Coronary Intervention in Patients with Chronic Total Occlusion
Authors: Zhao Xia , Yuan Xian , Zhong Yi , Wang Gang
Published: February 2022

Background and Objective. Percutaneous coronary intervention (PCI) is expansively used in the treatment of chronic total occlusion (CTO), but there is a lack of effective means to predict the prognosis of CTO patients undergoing PCI. The aim of this study was to construct a risk model that could effectively predict disease progression after PCI treatment in patients with CTO and enrich the means of clinical prediction of prognosis. Methods. The clinical data of 82 patients with CTO who underwent PCI in Lianshui County People’s Hospital were collected in this study. The patients were divided into training set (

n
=
54

) and validation set (

n
=
28

) by random sampling method. Statistical difference test was performed for clinical features of patients. Univariate and multivariate Cox regression analyses were performed to determine the risk factors affecting progression of CTO. Nomogram was used to construct a prediction model for disease progression.

C

-index was calculated, and the accuracy of the model was tested by calibration curve. Results. No statistically significant differences were incorporated in baseline characteristics of included patients (

p
>
0.05

). There were 25 patients with adverse cardiac events during follow-up in the training set and 13 in the validation set. The results of multivariate Cox regression analysis demonstrated that the important factors affecting postoperative disease progression mainly came down to age, BMI, diabetes, creatinine clearance rate, and

left
 
ventricular
 
fraction
<
40
%

. A nomogram was constructed and

C

-index was calculated. The calibration curve was then used to evaluate and predict risk model of disease progression. The result showed an internal validation

C

-index of 0.6219 and an external validation

C

-index of 0.6453, which indicated the good prediction performance of the model. Conclusion. The risk of disease progression in CTO patients treated with PCI can be effectively predicted by the risk model constructed in this study, which opens up a great possibility for enriching the means of predicting the prognosis of these patients in clinical practice.
Photoimmunotherapy for Managing Recurrent Laryngeal Cancer Cervical Lesions: A Case Report
Authors: Okamoto Isaku , Okada Takuro , Tokashiki Kunihiko , Tsukahara Kiyoaki
Published: February 2022

Photoimmunotherapy (PIT) targets and destroys tumor cells through irradiation with 690-nm red light after the administration of cetuximab sarotalocan sodium, which contains IRDye700DX bound to cetuximab. In Japan, PIT is a new treatment that is covered by insurance only for unresectable head and neck cancers. However, this treatment has conditional early approval. There have been no case reports describing the efficacy of this treatment in a real-world setting thus far. We report our experience with PIT for head and neck cancer. A 76-year-old man with laryngeal cancer underwent radiation therapy and surgery. Skin involvement in the right submandibular region was subsequently noted. We diagnosed local recurrence and performed PIT for this lesion. Partial response was achieved after the first PIT session, and progressive disease was diagnosed after the second session. Many aspects of PIT remain unclear and should, therefore, be clarified in further research. Despite this uncertainty, PIT may become an effective treatment strategy for head and neck cancer if the patient selection criteria are delineated.
Investigação dos impactos da lesão medular traumática na estrutura neuroanatômica de áreas corticais sensoriomotoras
Authors: Dyonísio Gabriela , Dhainner Dhainner Rocha , Carvalho Eduardo Batista de , Macedo Tulio Augusto Alves , Luppi Andrea de Martino , Soares Alcimar Barbosa
Published: February 2022

A perda do controle motor é uma das mais debilitantes consequências da lesão medular espinhal. A interrupção parcial ou completa das vias ascendentes sensoriais e vias descendentes motoras tornam o indivíduo incapaz de caminhar e realizar atividades de maneira funcional. A ocorrência da reorganização cortical sensório-motora espontânea imediatamente após a lesão e continuamente ao longo do tempo pode ocorrer em áreas específicas, bem como em todo córtex cerebral, evidenciado em estudos prévios com uso de exames de imagem. Entender a complexa interação entre alterações anatômicas, funcionalidade e reorganização cortical induzidas pela lesão medular, bem como definir seus efeitos, é crucial para avaliação das terapias de reabilitação e consequente melhora na qualidade de vida do sujeito. Neste estudo, imagens de Ressonância Magnética foram obtidas para explorar alterações morfológicas na Substância Cinzenta (SC) e Substância Branca (SB) no córtex cerebral de indivíduos com lesão medular torácica. Dois grupos de voluntários foram recrutados para esta pesquisa (portadores de lesão medular - Grupo Experimental; e não-lesionados – Grupo Controle). A comparação intergrupos foi realizada considerando ainda o tempo pós-lesão. A avaliação global do encéfalo não detectou alteração no volume da SC total. Diferenças volumétricas na SC cortical foram verificadas no giro pré-central e no sulco pré-central inferior. A alteração observada no giro pré-central ocorreu no hemisfério esquerdo, responsável pelo controle motor do membro inferior direito, compatível com a dominância dos voluntários de ambos os grupos (destros). Os achados fornecem evidências de que o tempo pós-lesão não influenciou em maior perda volumétrica global significativa. No entanto, alterações em regiões específicas, associadas ao controle motor de regiões abaixo da lesão, foram evidenciadas neste estudo.
Resenha: Experimentações em Diamantina: a prática do IPHAN em uma cidade tombada. Gonçalves, Critiane Souza. São Paulo: Editora Unifesp, 2019. 256p.
Authors: Barros Maíra de Camargo
Published: February 2022

O livro Experimentações em Diamantina: a prática do Iphan em uma cidade tombada, da arquiteta Cristiane Souza Gonçalves, é, sem dúvida, um importante exemplo de pesquisa. Através de uma linguagem erudita, porém de fácil compreensão, a autora apresenta-nos e questiona uma série de documentos encontrados sobre as primeiras décadas de atuação do Iphan na cidade de Diamantina, localizada na região centro--norte de Minas Gerais.
Museus nas universidades ou museus universitários?: uma breve análise comparativa entre o Museu Paulista da Universidade de São Paulo (Brasil), o Pitt Rivers Museum da University of Oxford (Inglaterra) e o Museum Of Anthopology da University of British Columbia (Canadá)
Authors: Silva Rodrigo da
Published: February 2022

Este artigo busca comparar três museus universitários (o Museu Paulista da Universidade de São Paulo/Brasil, o Museum of Anthropology da University of British Columbia/Canadá e o Pitt Rivers Museum da University of Oxford/Inglaterra) a partir de algumas de suas dimensões: perfil institucional, modelos de gestão, financiamento e desafios presentes. O objetivo deste estudo comparativo é buscar um denominador comum que permita compreendê-los dentro da categoria “museus universitários” para além do fato de comporem estruturas universitárias. A base para este debate foi construída durante o seminário internacional Designing the Future: Management and Sustainability in Museums realizado em 2019 pelo Museu Paulista da Universidade de São Paulo em parceria com o SESC Ipiranga, no qual os três museus citados compuseram uma mesa de debate dedicada ao tema dos modelos de sustentabilidade aplicados aos museus universitários.
Atos Secretos do Senado: uma análise do enquadramento de Sarney no jornalismo do CQC
Authors: Lautenschleger Gabriel
Published: February 2022

As análises e apresentações sobre enquadramento nos programas jornalísticos, principalmente na televisão brasileira são bastante carentes na questão de assuntos trabalhados. O campo televisivo é muito amplo e pouco trabalhado em questões que trazem a luz análises de agendamento e enquadramento midiático, a televisão é estudada basicamente em assuntos referentes à análise de conteúdo e estudos de recepção, mas não em vista das Teorias do Jornalismo. O presente artigo pretende um estudo do novato programa Custe o Que Custar (CQC) e o enquadramento dado por esse programa do novo jornalismo ao caso de Atos Secretos praticados no Senado Nacional pelo Senador José Sarney
As mulheres pelas capas: a beleza como valor feminino
Authors: Oliveira Janaina Cruz de , Peruzzolo Adair Caetano
Published: February 2022

A comunicação como uma relação envolve sujeitos que constroem seus discursos representando-se uns aos outros o tempo todo. As representações de valores femininos nos discursos das capas das revistas femininas é uma construção social de modos de ser mulher na sociedade. Ao buscarmos as formas como os valores femininos são representados nas capas das revistas femininas populares e não-populares da Editora Abril, encontramos também a construção de sentidos que esses dispositivos oferecem ao ser mulher: sentidos diferentes para públicos diferentes, representados através de valores comuns às mulheres, como beleza, relacionamentos e saúde