bluuebunny/crossref_metadata_2025 huggingface dataset:
Determining the effect of frailty on survival in advanced ovarian cancer: study protocol for a prospective multicentre national cohort study (FOLERO)
Authors: Hunde Daniel , Ekerstad Niklas , Asp Mihaela , Kannisto Päivi , Wedin Madelene , Palmqvist Charlotte , Dahm-Kähler Pernilla , Brandberg Yvonne , Abraham-Nordling Mirna , Åhlund Kristina , Mörlin Vilhelm , Groes-Kofoed Nina , Salehi Sahar
Published: February 2025

Background and purpose: There is an urgent need to improve patient-selection to surgical treatment in advanced ovarian cancer as our results showed that cytoreductive surgery was without effect or even detrimental in a yet unknown subgroup of women. With an ageing population, 30% of women with advanced ovarian cancer in Sweden are >75 years. Nevertheless, there are no recommendations on patient-selection, albeit treating an unselected population in a public and centralized health care setting. Little attention has been placed on frailty assessments in oncology, despite their potential to stratify the risk of adverse outcome and mortality. Consequently, we hypothesize that frailty is a predictor of poor survival.
Patients and methods: In this Swedish multi-centre prospective cohort study, where the exposure is frailty, consecutive women with advanced ovarian cancer scheduled for surgery with curative intent are eligible for inclusion. Three different frailty instruments are evaluated preoperatively, blinded to the caregiver. The primary outcome is 2-year overall survival. With a fixed sample size of 450 patients, a two-sided α of 0.05 and β of 0.20, the study is powered to detect a difference in 2-year survival of 12.5% by frailty, assuming a 20% prevalence of frailty.
The result of the study will have a direct impact on clinical management and patient-selection as the results are expected to have a high external validity.
Total study-time is 5 years, with 3 years of accrual. All participating centres started accrual by September 2024. Presentation of data on primary outcome is expected 2029.
Study registration: ClinicalTrials.gov NCT06298877
Retrospective analysis of patients with immediate decannulation in severe acquired brain injury (RAPID-SABI)
Authors: Van Hooff Robbert-Jan , Lindelof Mette , Ghaziani Emma , Hørmann Thomsen Trine , Kruuse Christina , Gunge Riberholt Christian , Rath Charlotte
Published: February 2025

Objective: To examine an early decannulation protocol in adult severe acquired brain injury (SABI) patients.
Design: Retrospective, observational cohort study.
Subjects/patients: Tracheotomized SABI patients ≥ 18 years admitted to a neurorehabilitation unit.
Methods: Primary outcome measure was difference in survival rate within first year of discharge. Secondary outcome measures were respiratory infections treated with antibiotics, rate of re-cannulation, time from admission to decannulation, length of stay, difference in rate of re-admission due to pneumonia within first year of discharge and difference in rate of tracheal tube dependency within first year of discharge.
Results: No statistical significance in survival rate within the first 12 months from discharge was found. Median time from admission to decannulation was 32 days (interquartile range [IQR] 14–61) vs 9 days (IQR 0–13) in the control and intervention group, respectively (p < 0.0003). Median length of stay was 66 days (IQR 54–92) in the control group vs 60 (IQR 48–75) days in the intervention group (p = 0.168).
Conclusion: A new early decannulation protocol omitting evaluation of tolerance to tracheostomy tube capping and fiberoptic endoscopic evaluation of swallowing was non-inferior to previous procedures in survival rate within first year of discharge. The early decannulation protocol allowed for significantly earlier decannulation.
Sarcopenia y Enfermedad de Alzheimer: Mecanismos fisiopatológicos compartidos y estrategias integrales para promover un envejecimiento saludable. Revisión bibliográfica
Authors:   Universidad Técnica de Machala Ecuador, Garay Largo Tannya Thalia
Published: February 2025

El artículo analiza la relación entre la sarcopenia y la enfermedad de Alzheimer (EA), enfocándose en sus mecanismos fisiopatológicos compartidos y estrategias para promover un envejecimiento saludable, destacando los mecanismos fisiopatológicos compartidos entre la sarcopenia y la EA, y desarrollar estrategias preventivas para mejorar la calidad de vida de los adultos mayores. A través de una revisión bibliográfica basada en investigaciones publicadas en los últimos 10 años, con búsquedas realizadas en bases de datos reconocidas como PubMed, Web of Science y Scopus, utilizando términos claves relacionados con la sarcopenia y la enfermedad de Alzheimer. La selección de los estudios relevantes se llevó a cabo siguiendo criterios estrictos de inclusión y exclusión, asegurando la pertinencia y calidad de las fuentes analizadas.

Se identifica los mecanismos compartidos entre la sarcopenia y el Alzheimer, como la inflamación, el estrés oxidativo y la disfunción mitocondrial, impactan la funcionalidad física y cognitiva. La acumulación de β-amiloide y tau agrava ambas condiciones. Para prevenir y gestionar estas enfermedades, son esenciales las intervenciones multimodales que integran ejercicio, nutrición balanceada y estimulación cognitiva, junto con diagnósticos tempranos y educación sobre hábitos saludables y control de factores de riesgo como la obesidad e hipertensión. En conclusión, la interrelación entre la sarcopenia y la EA subraya la necesidad de enfoques integrales y personalizados para la prevención y el tratamiento, con el objetivo de mejorar la calidad de vida y reducir el impacto de estas condiciones en los adultos mayores.
Transformación Digital y Modelos de Negocio
Authors:   Universidad Técnica de Ambato Ecuador, Villegas Rojas Jenny Soledad
Published: February 2025

La transformación digital ha redefinido la estructura y dinámica de los modelos de negocio en diversos sectores. Este estudio examina cómo la digitalización impulsa la evolución de los modelos empresariales, identificando los factores clave que facilitan la innovación y el crecimiento organizacional.

Mediante una revisión sistemática de la literatura y el análisis de casos representativos, se analizan los efectos de la digitalización en la generación de valor, la eficiencia operativa y la experiencia del cliente. Se destacan tecnologías emergentes como la inteligencia artificial, el Big Data, el Internet de las cosas y la computación en la nube, que han potenciado la automatización y la personalización de productos y servicios.

Los resultados evidencian que las organizaciones que implementan estrategias digitales logran una ventaja competitiva y una mayor sostenibilidad en el mercado global. No obstante, la transformación digital conlleva desafíos, como la necesidad de desarrollar nuevas competencias organizacionales, gestionar la resistencia al cambio y abordar los riesgos de ciberseguridad.

En conclusión, la digitalización no solo modifica los modelos de negocio tradicionales, sino que también da lugar a nuevos paradigmas empresariales basados en la innovación y la adaptabilidad. Este estudio proporciona un marco conceptual para comprender cómo las organizaciones pueden capitalizar la transformación digital para mejorar su desempeño y asegurar su relevancia en un entorno altamente tecnológico y dinámico.
A Case of Late Presenting Retinitis Pigmentosa in an Adult Female
Authors: H Vongole , A Onkar , R Kumari , M Gupta
Published: February 2025

This study aimed to bring to light a case of non-syndromic Retinitis Pigmentosa in a middle-aged female. A 39-year-old female
complained of blurred vision that started 3 years ago. It initially affected her distant vision, mainly in low-light conditions,
followed by the involvement of near vision as well. On fundus examination, bony spicule-like pigmentation was found
peripherally, waxy pallor of the optic disc was present, severe arteriolar attenuation was found, and macular edema was
present. The patient was prescribed vitamin A 15,000 IU and asked to come for a follow-up for a low visual aid assessment. This
case report highlights the devastating effects of Retinitis Pigmentosa and the need for early diagnosis to slow the progression
of vision loss. The peculiarity of this report lies in the fact that the patient showed symptoms very late, when usually RP
is diagnosed in adolescence which also progressed rapidly within 3 years to involve distant and far vision. The absence of
any family history is also notable as it may indicate an autosomal recessive inheritance with low-penetrance or a sporadic
mutation.
Effect of Various Oils on the Production of Lipase by Rhodotorula mucilaginosa and Yarrowia lipolytica Isolated from Spoiled Labneh
Authors: Kebabci Özgür
Published: February 2025

The content of the medium is very important in the production of lipase enzyme. Microbial lipase production is carried out by adding carbon source to the compounds in the minimal medium. The use of olive oil is quite common in lipase production medium. In this study, it was aimed to increase lipase production by adding different oils instead of olive oil to the reference lipase production medium. For this purpose, corn oil, sunflower seed oil, walnut oil, hazelnut oil, safflower oil, avocado oil, organic sunflower seed oil, organic canola seed oil, organic flaxseed oil, organic soybean oil, pumpkin seed oil, black cumin oil, St. John’s wort oil and sesame oil were evaluated in terms of lipase production. Rhodotorula mucilaginosa and Yarrowia lipolytica strains, which were isolated, purified, and identified, and which caused spoilage in labneh were studied in lipase production. When olive oil was used in lipase production, the lipase activity of R. mucilaginosa was determined as 7.50 U/ml, and that of Y. lipolytica was determined as 8.09 U/ml. It was determined that the lipase activity of R. mucilaginosa was increased by organic linseed oil as 10.67 U/ml, St. John’s Wort oil as 10.17 U/ml, and organic sunflower oil as 9.67 U/ml, respectively. It was determined that the lipase activity of Y. lipolytica was increased by St. John’s Wort oil as 13.50 U/ml, organic linseed oil as 10.84 U/ml, and organic sunflower oil as 10.33 U/ml, respectively. It was also observed that black cumin oil inhibited the growth of both yeast strains.
Emočná regulácia a flexibilita v psychopatológii a psychickej pohode
Authors: Pilárik Ľubor , Heinzová Zuzana , Galasová Miroslava , Kaliská Lada , Baláž Ďurechová Anna , Slovíková Kristína , Virostková Nábělková Eva , Ladecký Jakub , Bartošíková Paulína
Published: February 2025

V publikácii sa prelínajú témy sledujúce emočnú reguláciu v súvislostiach so psychopatológiou, zvládaním, emočnou inteligenciou, socializáciou emócií či psychickou pohodou, s témami, ktoré sa viac koncentrujú na tvorbu a overovanie existujúcich či nových nástrojov na meranie emočnej flexibility. Špecifické postavenie má posledná kapitola, v ktorej je predstavený novovytváraný autorský test riešiteľov projektu zameraný na meranie flexibility stratégií regulácie emócií nesúci názov Situačný test emočnej flexibility (STEF.02).
ANALISIS PERBANDINGAN QOS PFSENSE, OPNSENSE, DAN FLEXIWAN MENGGUNAKAN METODE LOAD BALANCING
Authors: Sugianto Sugianto , Haeruddin Haeruddin , Prasetyo Stefanus Eko
Published: February 2025

Peningkatan konsumsi internet di Indonesia dari 2018 hingga kuartal pertama 2022 menunjukkan pertumbuhan yang signifikan, dengan jumlah pengguna aktif mencapai 210 juta dari total populasi sebesar 272,682 juta. Angka ini mencerminkan penetrasi internet sebesar 77,02%. Internet menjadi layanan yang sangat penting karena memberikan akses cepat dan efisien terhadap informasi. Seiring dengan meningkatnya jumlah pengguna internet, jumlah Penyedia Layanan Internet (ISP) yang tersedia juga bertambah. Ketersediaan dan kualitas layanan internet menjadi faktor kunci yang mempengaruhi minat masyarakat dalam memanfaatkannya. Untuk mendukung kualitas layanan internet, manajemen bandwidth menjadi aspek yang krusial. Salah satu mekanisme yang digunakan adalah Load Balancing, yaitu metode untuk membagi beban lalu lintas jaringan melalui beberapa gateway yang tersedia sehingga tidak terfokus pada satu ISP. Dalam implementasinya, perangkat seperti pfSense, OPNsense, dan flexiWAN sering digunakan sebagai solusi load balancer karena sifatnya yang open-source, fleksibel, dapat dikonfigurasi melalui antarmuka web, serta mendukung fungsi Load Balancing. Selain pfSense dan OPNsense, solusi inovatif seperti flexiWAN kini juga dapat diadopsi sebagai platform SD-WAN open-source yang menawarkan fleksibilitas tinggi dalam pengelolaan lalu lintas jaringan. Dengan kemampuan integrasi yang baik, flexiWAN memungkinkan perusahaan atau organisasi untuk mengoptimalkan jaringan mereka melalui manajemen lalu lintas yang canggih dan efisien. Penelitian ini membandingkan kinerja Load Balancing dari router pfSense, OPNsense, dan flexiWAN pada Bitbox Open Network Appliance. Hasil penelitian menunjukkan bahwa sistem load balancing pada pfSense memberikan kinerja lebih baik dibandingkan OPNsense berdasarkan nilai QoS, meskipun penggunaan resource CPU pada pfSense lebih tinggi. Sebaliknya, penggunaan RAM pada pfSense lebih rendah dibandingkan OPNsense. Kehadiran teknologi seperti flexiWAN dapat menjadi alternatif baru yang memberikan keunggulan tambahan dalam mendukung pengelolaan bandwidth secara optimal.
Youth Spaces and Places Design for the Development of Socio-spatial Communal Values
Authors:   Department of Architecture, Faculty of Built Environment and Surveying, Universiti Teknologi Malaysia (UTM), Malaysia, Ismail Alice Sabrina
Published: February 2025

Youth is best understood as a transition period from childhood dependence to adulthood independence between 18 and 24 years old. This growth phase is crucial as the youth is more fluid than fixed age groups during this time and is exposed to issues and challenges from advancing technology and socio-cultural problems. However, in the context of the built environment, most of the current designs, namely in urban cities, lack concern towards the youth community's needs and aspirations and are less empowering in both representation and inclusivity of youth through the participatory design processes. This resulted in the provision of spaces that are not autonomous, enclosed, unsafe, and inaccessible, which did not fully manage to engage and improve the well-being of youth communities. Furthermore, fewer studies have been provided on designing youth spaces and places in Malaysia based on theoretical design principles and approaches. This is because many past studies focus only on youth social empowerment and political engagement, technology advancement and utilization amongst youth, youth employment and macroeconomics factors, intellectual wellness, and youth resiliency in current society. This study, therefore, is crucial as it aims to highlight how to design better youth spaces and places that concern socio-spatial aspects towards enhancing the needs of youth and aiming at holistic empowerment of them, making them more resilient. In achieving this, best practices of recognizing youth needs and interests will be collectively gathered through a qualitative approach using the crit sessions and focus group discussions from diverse youth backgrounds as methods for data collection. This includes referencing established case studies from literature reviews on prominent youth centres designed to support the findings. The determination of the findings is then transformed into design strategies focusing on socio-spatial aspects to accommodate youth needs in terms of a sense of attachment and community. This paper benefits designers and authorities as a reference for creating better youth spaces and places to accommodate youth needs from different walks of life and backgrounds.
Effects of ESG on the relationship between ownership concentration and cash holdings
Authors: Bo Le , Li Bing , Li Peixuan
Published: February 2025

This paper examined the impact of ownership concentration on cash-holding levels, including 4832 Chinese-listed companies. This study employed the Fixed Effects Model and the Generalized Method of Moments for quantitative analysis. This study shows a positive relationship between ownership concentration and cash holdings. Furthermore, ESG can mitigate the direct correlation between ownership concentration and corporate cash holdings. Finally, the impact described above is particularly noticeable for non-state-owned enterprises. In summary, the empirical findings offer a new analytical perspective on the cash-holding decisions of corporations in the Chinese capital market. Furthermore, this study illustrates the importance of ESG in corporate development to mitigate ownership concentration and excess cash holdings. As a result, the findings show that non-financial reporting, such as ESG disclosure, can reduce agency issues, making more accurate assessments of enterprise performance.
Postanesthetic neurologic signs progressing to seizures in 2 dogs and 1 cat with unoperated congenital portosystemic shunts after non–shunt-related surgery
Authors: Mullins Ronan A. , O’Sullivan Joseph , Simpson Matthew , Lipscomb Victoria J.
Published: February 2025

OBJECTIVE

To describe the development of neurologic signs progressing to seizures in 2 dogs and 1 cat with unoperated single congenital portosystemic shunts (CPSSs) after general anesthesia for non–shunt-related surgery and no intraoperative shunt manipulation.

ANIMALS

2 dogs (dog 1 [a 5-year-old 7.1-kg castrated male Bichon Frise] and dog 2 [a 10-year-old 7.3-kg castrated male Bichon Frise]) and 1 cat (cat 1 [a 2-year-old 3.8-kg castrated male Ragdoll]).

CLINICAL PRESENTATION

Medical records from the University College Dublin Veterinary Hospital and Royal Veterinary College Queen Mother Animal Hospital were searched for dogs and cats with unoperated CPSSs that developed neurologic signs progressing to seizures after general anesthesia for non–shunt-related surgery between January 1, 2015, and June 31, 2024.

RESULTS

3 animals were identified. Dogs 1 and 2 both underwent cholecystectomy, whereas cat 1 underwent jejunal enterectomy. None had known preoperative seizures, although both dogs had experienced prolonged anesthetic recovery after previous surgery and the cat had a 3-day history of ataxia, walking into walls, and generalized weakness. All 3 animals developed severe neurologic signs including seizures within 48 hours postoperatively. Both dogs were euthanized before hospital discharge: dog 1 for suspected aspiration pneumonia coupled with severe neurologic signs and dog 2 for refractory neurologic signs. Cat 1 survived to hospital discharge and underwent 2 subsequent CPSS attenuation surgeries.

CLINICAL RELEVANCE

Postanesthetic neurologic signs can occur in animals with CPSSs without intraoperative shunt manipulation. This possible complication should be discussed with owners of animals with unoperated CPSSs that require general anesthesia for non–shunt-related surgery.
Novel Metaheuristic Algorithms and Their Applications to Efficient Detection of Diabetic Retinopathy
Authors: Hassaballah Mahmoud , Hameed Mohamed Abdel
Published: February 2025

It is an extremely important to have an AI-based system that can assist specialties to correctly identify and diagnosis diabetic retinopathy (DR). In this study, we introduce an accurate approach for DR diagnosis using machine learning (ML) techniques and a modified golf optimization algorithm (mGOA). The mGOA optimizes ML classifiers through finding the best available parameters with respect to objective functions, hence decreases the number of features and increases the classifier’s accuracy. A fitness function is employed to minimize the feature number of the medical dataset. The obtained results showed superiority of the mGOA with higher convergence speeds without extra processing costs across the datasets compared with several competitors. Also, the mGOA attained maximum accuracy and optimally reduced the number of features in the binary and multi-class datasets achieving the best CEC’2022 benchmark results compared with other metaheuristic algorithms. Based on this findings, three optimized ML classifiers called mGOA-SVM, mGOA-radial SVM,and mGOA-kNN were introduced as tools for classification of diabetic retinopathy disease and their performance was assessed on Messidor and EyePACS1 datasets. Experimental results demonstrated that mGOA-SVM and mGOA-radial SVM achieved remarkable accuracy in classification of DR disease with an average accuracy of 98.5% and precision of 97.4%.
OPTIMASI PENGGUNAAN EXCAVATOR DAN DUMP TRUCK PADA PROYEK X DENGAN METODE LINEAR PROGRAMMING
Authors: Imanda Krisna , Sutandi Arianti
Published: February 2025

The growth of construction projects in Indonesia demands efficient utilization of heavy equipment in infrastructure projects. One of the significant cost factors involves the use of heavy machinery such as Excavators and Dump Trucks. This study employs linear programming to optimize the usage of Excavators and Dump Trucks in a soil excavation project in Bogor. By minimizing the operational costs of heavy machinery, the research identifies the optimal number of equipment required to achieve the targeted volume of soil. The results indicate that employing the LP model with LINGO software significantly reduces project costs, saving approximately Rp368,445,800 per week compared to field costs. This research contributes to enhancing operational efficiency and reducing costs in construction projects through the optimization of heavy equipment utilization. The optimization of heavy equipment utilization in construction projects not only improves cost efficiency but also ensures the timely completion of projects within budget constraints. By leveraging mathematical models such as linear programming, this study demonstrates a practical approach to achieving these goals. The findings underscore the importance of strategic planning and efficient resource allocation in enhancing overall project performance and competitiveness in the construction industry.
Abstrak
Pertumbuhan industri konstruksi di Indonesia menuntut penggunaan alat berat yang efisien dalam proyek-proyek infrastruktur. Salah satu faktor biaya terbesar adalah penggunaan alat berat seperti excavator dan dump truck. Penelitian ini menggunakan pendekatan linear programming untuk mengoptimalkan penggunaan excavator dan dump truck dalam proyek penggalian tanah di Bogor. Dengan meminimalkan biaya operasional alat berat, studi ini berhasil mengidentifikasi penggunaan optimal alat berat yang diperlukan untuk mencapai volume tanah yang ditargetkan. Hasilnya menunjukkan bahwa penggunaan model linear programming dengan bantuan program LINGO dapat mengurangi biaya proyek secara signifikan, sekitar Rp368.445.800 per minggu, dibandingkan dengan biaya lapangan. Penelitian ini memberikan kontribusi dalam meningkatkan efisiensi operasional dan mengurangi biaya pada proyek konstruksi melalui optimasi penggunaan alat berat.
Prevalence of screen use in children: an observational study in the extreme south of Santa Catarina
Authors: Borges Ketlyn da Luz , Bianchini Bruna Melo , Milanesi Ana
Published: February 2025

Objective: Excessive exposure to screens during early childhood has been progressively associated with inadequate cognitive and psychosocial development. In this sense, this study has as objective to assess the prevalence of screen use in early childhood in the pediatric outpatient clinics of a university in the extreme south of Santa Catarina in the second half of 2022. Methods: Cross-sectional observational study, with primary data collection, in the predetermined location, and that involved 135 patients from zero to six years, whose parents and/or guardians answered the questionnaire prepared and signed the informed consent form. Results: Of the total children evaluated, an 85.92% prevalence of screen use was found. The main technological devices used were television (73.3%), followed by cell phones (19.8%). The average daily exposure time found was 1.07 hours. Of the twenty-one variables tested, six showed a significant association with screen exposure time: age, type of screen, school/daycare attendance, presence of physical activity stimuli, screen used during meals, and presence of limit on screen use. Conclusions: Was observed highly prevalent and early screen use in early childhood in the population studied. The sociodemographic profile findings, as well as the associations between screen time and predisposing factors, expand the brazilian literature, showing similarities and differences with previous studies.
GAMBARAN CAREER ADAPTABILITY PADA KARYAWAN DI JABODETABEK
Authors: Putri Anastasya Ananta , Ronauli Puji Tania
Published: February 2025

Career adaptability has become a crucial topic, particularly for young people navigating dynamic market changes and workplace challenges while pursuing their dream jobs. These factors heavily influence how individuals plan and build their careers, underscoring the importance of career adaptability—an individual's capacity to manage current and future tasks, job role changes, and transitions at work, all of which significantly affect their lives. This study examined the career adaptability of 307 employees aged 17–60 in the Jabodetabek area using a quantitative approach and descriptive analysis. Data were collected with the Career Adapt-Abilities Scale Indonesian Form (CAAS-Indonesian Form). The results indicated that the four dimensions of career adaptability—concern, control, curiosity, and confidence—were at moderate levels. Additionally, a positive correlation was observed between career adaptability and job satisfaction. Future research should explore the relationship between job satisfaction and career adaptability in greater detail.
RESILIENSI IBU BEKERJA YANG MEMILIKI ANAK DENGAN GANGGUAN PENDENGARAN
Authors: Lubuk Frederica Ranithya , Widyawati Yapina
Published: February 2025

Parents of hearing-impaired children have various challenges that can cause stress. As they work, these challenges may increase. However, they must still be able to facilitate optimal care for their child’s development, especially at the age of 5-12, because children start to enter social environments. Resilience helps individuals to survive and adapt when experiencing difficulties. Therefore, it is important for parents to have resilience which affects their psychological well-being and their children’s quality of life. The research uses qualitative methods with phenomenological design and thematic analysis. The participants are hearing mothers, who work and have one child with hearing impairment aged 5-12 years old. This research found that all three participants showed resilience after accepting their child’s condition and going through unique dynamics. Perception of stressors, understanding of children’s characteristics, coping abilities, social support, positive interpretation, spirituality, and social support, play a role. Therefore, parents can continue to learn about their child’s condition and seek social support.
HUBUNGAN ANTARA ACADEMIC SELF-EFFICACY DENGAN CAREER ADAPTABILITY PADA MAHASISWA TINGKAT AKHIR DI JAKARTA
Authors: Jessica Joanna , Kembaren Esther Muliana
Published: February 2025

One of the major problems in Indonesia is the high unemployment rate, including among undergraduates. In 2023, the undergraduate unemployment rate was approximately 958,000, or 12% of the total rate. Several factors affect an individual's ability to get a job. One of them is career adaptability, the process of achieving career goals that needs to be developed since undergoing education, especially in final-year students. However, little effort has been made to improve students' career adaptability, such as academic self-efficacy. The purpose of this study is to examine the relationship between academic self-efficacy and career adaptability in final-year students in Jakarta. A correlational quantitative method was applied to 121 final-year students in Jakarta obtained through convenience sampling techniques. The measuring tool used to measure academic self-efficacy is The Academic Self-Efficacy Scale (TASES) which has gone through a validity test with a corrected-item total correlation score in the range of .384-.602 and Cronbach's alpha reliability score of .885. Meanwhile, the measuring tool for career adaptability is the Career Adapt-Abilities Scale (CAAS) with validity test results in the range of .322-.652 and a reliability score of .905. Based on the results of the correlation test with Spearman's correlation, there was a significant positive relationship between academic self-efficacy and career adaptability in final-year students in Jakarta, with a Spearman's Rho score of .636, p-value < .01. It can be concluded that the higher the academic self-efficacy, the higher the career adaptability of final-year students. Self-confidence in academic ability helps individuals prepare for future careers.
RESILIENSI PADA PERAWAT ONKOLOGI RUMAH SAKIT KANKER X YANG PERNAH MENGALAMI COMPASSION FATIGUE
Authors: Gantari Regina Lintang Laras , Wibawa Dhevy Setya
Published: February 2025

The continuous workload and emotional burden experienced by oncology nurses at Hospital X can lead to compassion fatigue as a side effect of their work. The impacts include demotivation, low quality of care, and even risks to patient safety. This study aimed to examine the resilience process from compassion fatigue experienced by oncology nurses using qualitative methods. The researcher conducted semi-structured interviews with three nurses with different lengths of experience as oncology nurses. The results of this study showed that all three participants had achieved resilient reintegration with different ways to process it. The emotional burden due to the holistic issues of patients and their families and the complexity of care were the primary factors contributing to compassion fatigue. The research findings can be used to design preventive and remedial efforts to improve nurses' emotional and psychosocial well-being.
REPRESENTASI SOSIAL TENTANG GANGGUAN JIWA PADA MASYARAKAT YANG INGIN MENCARI BANTUAN PSIKOLOGIS FORMAL (STUDI PADA MASYARAKAT BANTEN YANG RELATIF MODERN)
Authors: Prawiro Ferdinand , Vereen Agnes
Published: February 2025

Banten is one of the provinces that ranks first in health centers that organize mental health efforts. In Banten Province, the prevalence of patients with mental disorders who received treatment and were not abandoned was only 32.16%. With adequate knowledge and access to mental health services, there is no behavior to seek formal psychological help in there. This study aims to understand the meaning of mental disorders in Bantenese society using social representation theory with a structural approach and divided into two stages. The first stage aims to find the attributes of social representations of mental disorders using the word association method. There were 172 participants who participated in the first stage with a total of 929 responses. The categorization process was carried out, and 36 categories were obtained. Content analysis resulted in a Cohen's Kappa value of .588. The second stage aims to map the central core and peripheral attributes using the double denial technique. Results from 181 participants were tested with chi-square goodness of fit expected frequency. The social representation of mental illness in Banten society includes 17 attributes, 12 attributes of central core elements, and five attributes of peripheral elements. The results showed that Banten people have sufficient knowledge related to mental illness and sources of help. However, people still have negative views, concerns, cost considerations, feelings of helplessness, and confidentiality issues. Psychoeducation can be recommended as an intervention to increase public knowledge and shake abnormal and crazy attributes in peripheral elements.
Metodologias ativas de aprendizagem na educação médica
Authors: Pereira Adriana Vieira , Oliveira Beatriz Rocha de , Silva Gabriel Arruda , Carvalhêdo Isabela Moreira Gomides Sardinha , Palhares Julia Batista Alves Martinez , Silva Constanza Thaise Xavier
Published: February 2025

Objetivo: Identificar quais são as ferramentas utilizadas nas metodologias ativas que auxiliam na formação médica brasileira. Métodos: Trata-se de uma revisão integrativa, a busca de artigos foi realizada nas bases de dados CAPES, SciELO e LILACS. A busca foi realizada em abril de 2024. Os Descritores em Ciência da Saúde (DeCS) foram: Estudantes, Ensino-Aprendizagem, Material de Ensino e Educação Médica e seus correspondentes em inglês, com as combinações dos operadores booleanos AND e OR. Os critérios de inclusão foram: publicações em português e inglês, estudos originais de natureza primária, de livre acesso, disponibilizados na íntegra e publicados entre 2019 e 2024. Resultados: Após a aplicação dos critérios, foram selecionados 15 estudos. Foram elencadas 4 principais ferramentas que auxiliam na aprendizagem: aprendizagem baseada em problemas, aprendizagem baseada em equipe, estudo de caso e ensino baseado em simulação. Considerações finais: Verificou-se efetiva aplicação das ferramentas analisadas, e seus aspectos de influência, como protagonismo, motivação e a aquisição de conhecimento pelos alunos. As ações educacionais baseadas nas metodologias ativas consolidam a construção coletiva de conhecimentos por significação, em que diferentes situações da realidade vivenciadas são compartilhadas, democratizando oportunidades, para garantir uma educação permanente em saúde
A eficiência de novas tecnologias na terapêuticas calcificação valvar
Authors: Alencar Lucas Rezende de , Viana Cassiano Ossipe dos Santos , Cronemberger Lucas Rocha , Oliveira João Pedro Nascimento Lagos , Ferreira Lucas Luz , Barbosa João de Sousa Pinheiro
Published: February 2025

Objetivo: Investigar como os avanços na compreensão dos mecanismos moleculares da calcificação valvar podem impactar o desenvolvimento e a eficácia das novas terapias emergentes para o tratamento dessa condição, comparando com os métodos tradicionais. Métodos: Esta revisão integrativa da literatura. PubMed e Biblioteca Virtual em Saúde (BVS), focando em artigos publicados nos últimos cinco anos, entre 2019 e 2024. O objetivo da revisão foi identificar estudos que abordassem os mecanismos moleculares da Calcificação da Válvula Aórtica (CAVD) e potenciais intervenções terapêuticas.  A busca foi realizada utilizando descritores Decs/MeSH relevantes, incluindo "calcification," "RNA," "valve calcification," e "aortic valve calcification." Inicialmente, 422 estudos foram identificados antes da triagem.  Resultados: A análise revelou avanços significativos com biomarcadores, como o cfDNA, IL-38 e microRNAs, e terapias experimentais com vitamina K2, curcumina e H₂S, que mostraram potencial em inibir a progressão da calcificação valvar. Considerações finais: As novas terapias moleculares apresentam resultados promissores para o tratamento da calcificação valvar. Contudo, estudos futuros devem incluir amostras maiores e mais diversificadas para validar sua eficácia em diferentes populações e, assim, ampliar a aplicabilidade clínica dessas tecnologias.
Conhecimento de gestantes acerca do diabetes mellitus gestacional e a efetividade da educação em saúde no pré-natal
Authors: Franco Camila Regina Sousa , Vieira Carla Beatriz Aguiar , Lopes Jamilly Andrade , Carvalho Sarah Milena Santos de , Nogueira Ana Larissa Araújo , Bogea Eduarda Gomes
Published: February 2025

Objetivo: Avaliar o conhecimento de gestantes sobre Diabetes Mellitus Gestacional (DMG) e a efetividade da educação em saúde no pré-natal. Métodos: Estudo transversal analítico quantitativo, realizado em Unidades Básicas de Saúde com gestantes. Aplicou-se questionário com variáveis sociodemográficas, perfil gestacional, efetividade da educação em saúde, conhecimento do DMG (adaptação do Diabetes Knowledge Questionnaire). Os dados foram analisados no STATA 14.0, utilizando-se do teste Chi-quadrado para avaliar diferenças entre níveis de conhecimento. Resultados: Participaram 269 gestantes, a maioria entre 23 e 31 anos (44,76%), ensino médio completo (70,26%), pardas (60,97%), união estável (36,43%) e renda de 1-3 salários (58,74%). Cerca de 78% alegaram ter ouvido falar no DMG, mas 52,79% não sabem o que é e 60,59% não sabem suas complicações. A média de consultas foi 5, onde 63,20% foram orientadas e 86,25% não participaram de ações de educação em saúde. Notou-se que a maioria daquelas com elevado nível tinham ensino superior completo (p=0,001), casadas (p<0,001), tinham renda maior que 3 salários (p=0,008), realizaram 6 ou mais consultas (p=0,001) e foram orientadas no pré-natal (p=0,004). Conclusão: As gestantes possuem baixo nível de conhecimento sobre o DMG e algumas características socioeconômicas e de qualidade do pré-natal estão associadas ao nível de conhecimento.
Genotype-phenotype spectrum and correlations in Chinese patients with keratinocytic epidermal naevus: A retrospective study of 22 cases
Authors: Li Zhongtao , Wang Sheng
Published: February 2025

Background

Keratinocytic epidermal naevus is characterised by hyperkeratotic lesions arranged along Blaschko’s lines. So far, multiple genes have been implicated, but there is no detailed data or genotype-phenotype correlation studies of keratinocytic epidermal naevi in Chinese patients.

Objective

To evaluate the clinical, histopathological and genetic features, genotype-phenotype correlations of keratinocytic epidermal naevus in the Chinese population.

Methods

A retrospective study of patients with keratinocytic epidermal naevi referred to the Department of Dermatology, West China Hospital, in the last four years. Medical history, clinical data, histopathological characteristics, and evidence of genetic mutations were collected from 22 unrelated Chinese patients with this problem.

Results

The distribution of the keratinocytic epidermal naevi exhibited right-side dominance. Non-epidermolytic epidermis naevus was much more common. Eight reported missense mutations were found in this study, which were detected in five genes, including HRAS, KRT10, FGFR3, GJB2, and PIK3CA. HRAS was the most commonly affected gene (9/22, 40.91%) in this study, with the c.37G>C (6/22, 27.27%) substitution representing a possible hotspot mutation. Mutation allele loads were higher in the affected lesions than blood samples. Epidermolytic epidermal naevus was found in three patients exclusively carrying KRT10 mutations. Inflammatory epidermal naevi were caused by mutations of KRT10 and PIK3CA. Most of the mosaic mutations detected in keratinocytic epidermal naevi patients were the same as germline mutations identified in systemic diseases caused by these genes.

Limitations

The retrospective nature of the study.

Conclusion

Our findings reveal the genotype-phenotype spectrum and their correlation amongst Chinese patients with keratinocytic epidermal naevi. In addition, our data underscores the importance of genetic testing in lesional skin to help characterise and categorise keratinocytic epidermal naevi, decide on a therapeutic strategy, and offer genetic counselling and prenatal diagnosis.
Utility of immunohistochemistry for immunoglobulin G4 in the diagnosis of pemphigus
Authors: Begum Shameera , Krishnamurthy Bhavani , Srinivasan Sowmya
Published: February 2025

Objectives:

Direct immunofluorescence (DIF) is the diagnostic gold standard for pemphigus. However, it is limited by the requirement of additional fresh-frozen tissue, immediate processing, and availability of a fluorescent microscope. The present study aims to assess the role of immunoglobulin G4 (IgG4) immunohistochemistry (IHC) on formalin-fixed paraffin-embedded tissue for the diagnosis of pemphigus by comparing IgG4-IHC results to DIF.

Materials and Methods:

IgG4-IHC was performed on formalin-fixed paraffin-embedded sections of lesional and perilesional skin biopsies of 30 cases of DIF-proven pemphigus and 30 non-pemphigus controls. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and diagnostic accuracy were analyzed for IgG4-IHC on lesional and perilesional biopsies to compare their diagnostic significance.

Statistical analysis:

Data were analyzed using the Statistical Package for the Social Sciences version 29. Sensitivity, specificity, PPV, NPV, and diagnostic accuracy of IgG4-IHC were calculated using standard formulae. Receiver operator curve analysis was performed for IgG4-IHC in lesional and perilesional skin to compare their diagnostic significance. The youden index was calculated using the formula “sensitivity + specificity – 1.” P < 0.05 was considered statistically significant.

Results:

Out of 30 cases enrolled for the study, 26 (86.6%) were diagnosed as pemphigus vulgaris and four (13.4%) as pemphigus foliaceous. The sensitivity, specificity, PPV, NPV, and diagnostic accuracy of IgG4-IHC for pemphigus on lesional biopsy were 66.7%, 100%, 100%, 75%, and 83.3% while the sensitivity, specificity, PPV, NPV, and diagnostic accuracy for the perilesional biopsy were 56.7%, 100%, 69.8%, and 78.3%, respectively.

Conclusions:

Our study indicated that IgG4-IHC is highly specific, but not sufficiently sensitive to replace DIF to diagnose pemphigus. IgG4-IHC on lesional skin is likely to be particularly valuable in a setting where a frozen section or immunofluorescence facility is not available. Further studies on larger samples are warranted to validate the role of IgG4-IHC in pemphigus.
РАЗРАБОТКА ДВУХСТУПЕНЧАТОГО ПРОЦЕССА АНАЭРОБНОЙ ПЕРЕРАБОТКИ СПИРТОВОЙ БАРДЫ НА ДЕЙСТВУЮЩИХ ОЧИСТНЫХ СООРУЖЕНИЯХ СПИРТОВОГО ПРОИЗВОДСТВА
Authors: ГЛАДЧЕНКО М А. , КАНУННИКОВА М А. , ГАЙДАМАКА С Н. , КОРНИЛОВА А А.
Published: February 2025

Сформулирован и реализован на практике подход, обеспечивающий корректировку проектного инженерного решения и вывод производственного процесса переработки отходов спиртового производства на целевые значения показателей ХПК (химического потребления кислорода), эффективности очистки и низкого выхода объемов сточных вод. Достигнуть целевого результата удалось путем замены исходно предложенного по коммерческому проекту анаэробного мезофильного (35 °С) реактора на двухступенчатый процесс анаэробного сбраживания спиртовой барды, включавший биореакторы периодического действия (SBR), функционирующие по принципу контакт процесса, перед подачей на вторую стадию - аэробной конверсии, включающей процессы нитриденитрификации. При разработке двухступенчатой системы анаэробной деградации барды в эксплуатацию было введено последовательно два SBR реактора с разными температурными режимами (на 1-ой ступени - термофильный 65 °С и на 2-ой ступени - мезофильный 35 °С)...

An approach has been formulated and put into practice to ensure that the design engineering solution is adjusted and the production process for processing waste from alcohol production is brought to the target values of COD (chemical oxygen demand), treatment efficiency and low yield of wastewater volumes. It was possible to achieve the target result by replacing the anaerobic mesophilic (35 °C) reactor initially proposed in the commercial project with a two-stage process of anaerobic digestion of distillery vinasse, which included batch bioreactors (SBR), operating on the contact process principle, before feeding it to the second stage - aerobic conversion, including nitri-denitrification processes. When developing a two-stage system for anaerobic degradation of vinasse, two SBR reactors with different temperature conditions were put into operation sequentially (at the 1st stage - thermophilic 65 °C and at the 2nd stage - mesophilic 35 °C). The proposed engineering solution made it possible to completely eliminate the consumption of artesian water for diluting the original distillery vinasse and, at the same time, in just 7 days (residence time at the 1st stage - 2 days, at the 2nd stage - 5 days) to achieve the efficiency of reducing the COD of the processed distillery vinasse at the level of 75-85 %...
ОПРЕДЕЛЕНИЕ ПРЕДЕЛЬНО ДОСТИЖИМОЙ АБЕРРАЦИОННОЙ КОРРЕКЦИИ ОПТИЧЕСКИХ СИСТЕМ РАЗЛИЧНОЙ СЛОЖНОСТИ
Authors: БЕЗДИДЬКО С Н.
Published: February 2025

На начальных этапах проектирования новых оптических систем необходимо спроектировать исходную оптическую систему, исходя из требований технического задания. При этом в большинстве случаев в качестве исходных оптических систем используют ранее разработанные оптические системы, полученные с помощью поиска прототипа из архива готовых оптических систем. При этом важнейшей задачей является задача изучения коррекционных возможностей различных типов оптических систем и выбора наиболее приемлемых вариантов систем для дальнейшего проектирования. В этом отношении одной из важнейших практических задач является задача выбора исходных оптических систем, наиболее целесообразных для применения при заданных в ТЗ значениях светосилы и углового поля зрения, а также оценка предельных значений светосилы и углового поля зрения для каждой рассматриваемых оптических схем. Указанные задачи не получили достаточного освещения в литературе и именно использование ортогональных аберраций и новых подходов по анализу аберрационных свойств оптических систем позволяют успешно решать подобные задачи.

At the initial stages of designing new optical systems, it is necessary to design the starting optical system based on the requirements of the technical specifications. In most cases, lens designer only can choose the starting optical system from previously developed systems or from patent information. In this case, the most important task is to study the correction capabilities of various types of optical systems and select the most suitable system options for further design. In this regard, one of the most important practical tasks is the task of selecting the starting optical systems that are most appropriate for use at the values of aperture ratio and angular field of view specified in the technical specifications, as well as assessing the limiting values of aperture ratio and angular field of view for each optical scheme under consideration. These problems have not received sufficient coverage in the literature, and it is the use of orthogonal aberrations and new approaches to analyzing the aberration properties of optical systems that make it possible to successfully solve such problems.