bluuebunny/crossref_metadata_2025 huggingface dataset:
Negotiation of Calcified Canals
Authors: Chaniotis Antonis , Sousa Dias Hugo , Chanioti Anastasia
Published: May 2024

The gradual formation of hard tissue along the root canal walls is a natural process associated with aging, typically progressing slowly over time. In reaction to tooth wear, operative procedures, vital pulp treatments, or regenerative endodontic procedures, hard tissue may also accumulate within the pulp canal space at a slow rate. In certain cases, such as dental trauma, autotransplantation, or orthodontic treatment, this deposition of hard tissue can accelerate unexpectedly, resulting in rapid narrowing or complete closure of the root canal space. This situation is called calcific metamorphosis (CM), root canal calcification, or pulp canal obliteration (PCO). Performing conventional endodontic therapy on severely calcified canals presents significant challenges and increases the risk of procedural accidents. Calcified canals introduce such complexity that dedicated negotiation concepts and specially designed instruments have been developed to deal with the challenge. This article seeks to review the existing methods for effectively navigating calcified canals and to introduce the buckling resistance activation test (BRAT) technique.
Iris Reconstruction: A Surgeon’s Guide
Authors: Ferro Desideri Lorenzo , Arun Kirupakaran , Doherty Grace , Bernardi Enrico , Anguita Rodrigo
Published: May 2024

Objectives: The aim of this review paper is to summarise surgical options available for repairing iris defects at the iris–lens plane, focusing on suturing techniques, iridodialysis repair, and prosthetic iris devices. Methods: A thorough literature search was conducted using multiple databases, including Medline, PubMed, Web of Science Core Collection, and the Cochrane Library, from inception to February 2024. Relevant studies were screened based on predefined criteria, and primary references cited in selected articles were also reviewed. Results: Various surgical techniques were identified for iris defect repair. Suturing methods such as interrupted full-thickness sutures and the McCannel technique offer solutions for smaller defects, while iridodialysis repair techniques address detachment of the iris from the ciliary body. Prosthetic iris devices, including iris–lens diaphragm devices, endocapsular capsular tension ring-based devices, and customizable artificial iris implants, provide options for larger defects, each with its own advantages and limitations. Conclusions: Successful iris reconstruction requires a personalised approach considering factors like defect size, ocular comorbidities, and patient preference. Surgeons must possess a thorough understanding of available techniques and prosthetic devices to achieve optimal outcomes in terms of both visual function and, nonetheless, cosmetic appearance.
Prevention and Risk Assessment of Cardiac Device Infections in Clinical Practice
Authors: Matteucci Andrea , Pignalberi Carlo , Pandozi Claudio , Magris Barbara , Meo Antonella , Russo Maurizio , Galeazzi Marco , Schiaffini Giammarco , Aquilani Stefano , Di Fusco Stefania Angela , Colivicchi Furio
Published: May 2024

The implantation of cardiac electronic devices (CIEDs), including pacemakers and defibrillators, has become increasingly prevalent in recent years and has been accompanied by a significant rise in cardiac device infections (CDIs), which pose a substantial clinical and economic burden. CDIs are associated with hospitalizations and prolonged antibiotic therapy and often necessitate device removal, leading to increased morbidity, mortality, and healthcare costs worldwide. Approximately 1–2% of CIED implants are associated with infections, making this a critical issue to address. In this contemporary review, we discuss the burden of CDIs with their risk factors, healthcare costs, prevention strategies, and clinical management.
Analysis of Safety and Efficacy of the Early Initiation of Antithrombotic Secondary Prevention in Patients Treated with Intravenous Thrombolysis for Acute Ischemic Stroke
Authors: Krastev Georgi , Mako Miroslav , Števková Zuzana , Havranová Romana , Andrášiková Kristína
Published: May 2024

Background and Objectives: Current guidelines and the alteplase product insert recommend that antithrombotic therapy be avoided within 24 h of intravenous thrombolytic therapy with rt-PA in acute ischemic stroke. Therefore, the rate of stroke recurrence is unclear in terms of early neurological deterioration, which we could prevent with the early administration of antithrombotic therapy. We do not know the effect of early antithrombotic therapy after intravenous thrombolysis with rt-PA in acute stroke on the outcome in patients after 90 days either. Design: Prospective monocentric observational cohort study. Methods: Data were collected from consecutive patients treated with alteplase for acute ischemic stroke between January 2015 and January 2023. We examined functional outcome at 90 days, including the risk of symptomatic intracranial hemorrhage and mortality rate as safety indicators and stroke recurrence events in both early and standard antithrombotic therapy at 24 h after intravenous thrombolysis. Results: A total of 489 patients were included, of which 278 (56.9%) were men. Of these, 407 (83.2%) patients received early antithrombotic therapy. No symptomatic intracranial hemorrhage occurred in any participants. There was a significantly higher number of patients with an excellent outcome (mRS 0-1) in early antithrombotic treatment (211 (53.1%) versus 28 (34.6%) in standard antithrombotic treatment (p = 0.002, OR 0.47, 95% CI: 0.28–0.76). Conclusions: Early antithrombotic treatment after intravenous therapy in patients with acute ischemic stroke revealed no safety concerns compared with standard antithrombotic therapy and resulted in a significantly higher proportion of patients with an excellent functional outcome.
The Transorbital Approach: A Comprehensive Review of Targets, Surgical Techniques, and Multiportal Variants
Authors: De Simone Matteo , Zoia Cesare , Choucha Anis , Kong Doo-Sik , De Maria Lucio
Published: May 2024

The transorbital approach (TOA) is gaining popularity in skull base surgery scenarios. This approach represents a valuable surgical corridor to access various compartments and safely address several intracranial pathologies, both intradurally and extradurally, including tumors of the olfactory groove in the anterior cranial fossa (ACF), cavernous sinus in the middle cranial fossa (MCF), and the cerebellopontine angle in the posterior cranial fossa (PCF). The TOA exists in many variants, both from the point of view of invasiveness and from that of the entry point to the orbit, corresponding to the four orbital quadrants: the superior eyelid crease (SLC), the precaruncular (PC), the lateral retrocanthal (LRC), and the preseptal lower eyelid (PS). Moreover, multiportal variants, consisting of the combination of the transorbital approach with others, exist and are relevant to reach peculiar surgical territories. The significance of the TOA in neurosurgery, coupled with the dearth of thorough studies assessing its various applications and adaptations, underscores the necessity for this research. This extensive review delineates the multitude of target lesions reachable through the transorbital route, categorizing them based on surgical complexity. Furthermore, it provides an overview of the different transorbital variations, both standalone and in conjunction with other techniques. By offering a comprehensive understanding, this study aims to enhance awareness and knowledge regarding the current utility of the transorbital approach in neurosurgery. Additionally, it aims to steer future investigations toward deeper exploration, refinement, and exploration of additional perspectives concerning this surgical method.
Combined Endoscopic Endonasal Transclival and Contralateral Transmaxillary Approach to the Petrous Apex and the Petroclival Synchondrosis: Working “Around the Corner” of the Internal Carotid Artery—Quantitative Anatomical Study and Clinical Applications
Authors: Donofrio Carmine Antonio , Corrivetti Francesco , Riccio Lucia , Corvino Sergio , Dallan Iacopo , Fioravanti Antonio , de Notaris Matteo
Published: May 2024

The endoscopic contralateral transmaxillary (CTM) approach has been proposed as a potential route to widen the corridor posterolateral to the internal carotid artery (ICA). In this study, we first refined the surgical technique of a combined multiportal endoscopic endonasal transclival (EETC) and CTM approach to the petrous apex (PA) and petroclival synchondrosis (PCS) in the dissection laboratory, and then validated its applications in a preliminary surgical series. The combined EETC and CTM approach was performed on three cadaver specimens based on four surgical steps: (1) the nasal, (2) the clival, (3) the maxillary and (4) the petrosal phases. The CTM provided a “head-on trajectory” to the PA and PCS and a short distance to the surgical field considerably furthering surgical maneuverability. The best operative set-up was achieved by introducing angled optics via the endonasal route and operative instruments via the transmaxillary corridor exploiting the advantages of a non-coaxial multiportal surgery. Clinical applications of the combined EETC and CTM approach were reported in three cases, a clival chordoma and two giant pituitary adenomas. The present translational study explores the safety and feasibility of a combined multiportal EETC and CTM approach to access the petroclival region though different corridors.
Revolutionizing Localized Lung Cancer Treatment: Neoadjuvant Chemotherapy plus Immunotherapy for All?
Authors: Ferrari Victoria , Helissey Carole
Published: May 2024

Lung cancer poses a significant public health challenge, with resectable non-small cell lung cancer (NSCLC) representing 20 to 25% of all NSCLC cases, staged between I and IIIA. Despite surgical interventions, patient survival remains unsatisfactory, with approximately 50% mortality within 5 years across early stages. While perioperative chemotherapy offers some benefit, outcomes vary. Therefore, novel therapeutic approaches are imperative to improve patient survival. The combination of chemotherapy and immunotherapy emerges as a promising avenue. In this review, we explore studies demonstrating the benefits of this combination therapy, its impact on surgical procedures, and patient quality of life. However, challenges persist, particularly for patients failing to achieve pathologic complete response (pCR), those with stage II lung cancer, and individuals with specific genetic mutations. Additionally, identifying predictive biomarkers remains challenging. Nevertheless, the integration of immunotherapy and chemotherapy in the preoperative setting presents a new paradigm in managing resectable lung cancer, heralding more effective and personalized treatments for patients.
Endovascular Recanalization and Carotid Stenting: The New Approach to Restore Cerebral Perfusion during Aortic Dissection
Authors: Agarkov Maxim , Kozlov Kirill , Senkina Ekaterina , Gornov Sergey , Linkova Natalia , Kechaeva Elena , Medvedev Dmitrii , Krasichkov Alexander , Dyatlova Anastasiia , Polyakova Victoria
Published: May 2024

A type A aortic dissection (TAAD) is a dangerous condition requiring emergency surgery. Due to the similarity of the symptoms of cerebral malperfusion in TAAD and the signs of ischemic stroke, a differential diagnosis of these diseases is not always available. Patients with TAAD after cerebral malperfusion can have a neurological deficit. Thrombolysis is performed in this case. It can worsen the patient’s condition and increase the risk of mortality and disability. The aim of the study is to evaluate the new approach to restoring cerebral perfusion during aortic dissection. This approach includes endovascular recanalization and carotid stenting. Methods: Two clinical cases of TAAD complicated by cerebral malperfusion are described. The first patient is 73 years old and was admitted as planned to perform transcatheter aortic valve implantation (TAVI) for grade III aortic stenosis. The patient underwent transcatheter aortic valve implantation (TAVI) on the second day after admission. The second patient is 60 years old and was hospitalized by an ambulance with strong hypertension and ischemia. The surgical correction of aortic dissection was postponed until the neurological status assessment in both patients. Results: The surgery to correct the aorta dissection was deemed inappropriate. The carotid arteries have been reanalyzed, and cerebral perfusion has been restored in a short time in both patients. Conclusion: Acute bilateral internal carotid occlusion is a potentially fatal TAAD outcome. Emergency endovascular recanalization and carotid stenting may be considered one of the few ways to restore cerebral perfusion.
Cardiopulmonary Resuscitation: Clinical Updates and Perspectives
Authors: Marsch Stephan , Sellmann Timur
Published: May 2024

Cardiopulmonary resuscitation (CPR) stands as a cornerstone in emergency care, representing the crucial link between life and death for victims of cardiac arrest [...]
The Multidisciplinary Mobile Unit (MMU) Program Bringing Hospital Specialist Geriatric Competencies at Home: A Feasible Alternative to Admission in Older Patients with Urgent Complaints
Authors: Nouvenne Antonio , Ticinesi Andrea , Siniscalchi Carmine , Rendo Martina , Cerundolo Nicoletta , Parise Alberto , Castaldo Giampiero , Chiussi Giulia , Carrassi Richard , Guerra Angela , Meschi Tiziana
Published: May 2024

Background/Objectives: Older patients are subject to a high number of Emergency Department (ED) visits and hospitalizations. Innovative strategies to manage geriatric urgencies in the community are thus needed. Methods: In this prospective observational study, we examined the case mix of a hospital-based domiciliary urgent care service tailored to older patients, called Multidisciplinary Mobile Unit (MMU), from January to September 2023. The service, activated by general practitioners or territorial specialists during workdays, provided domiciliary geriatric assessment, point-of-care diagnostics, including multi-site ultrasound and lab tests, and therapeutical measures, including intravenous treatment and insertion of invasive devices, with the goal of reaching on-site stabilization and avoiding ED referral. We collected data regarding multimorbidity, polypharmacy, and frailty according to the Clinical Frailty Scale (CFS), reasons for MMU activation, and diagnostic and therapeutical services provided. The assessed outcomes were immediate hospitalization after a visit, 30-day admission, and 30-day mortality. Results: Participants (n = 205, 102 M) were mostly aged (median age 83 years old), with multimorbidity and frailty (CFS median 6). The most frequent reasons for MMU activation were dyspnea (49%), cough (34%), and musculoskeletal pain (17%), while the commonest diagnostic test provided was thoracic ultrasound (81%). Only five patients (2.4%) were hospitalized immediately after MMU visit. The 30-day rate of hospitalization was 10.2%, with age, cancer, and abdominal pain as independent predictors on a stepwise binary logistic regression model. 30-day mortality was 4.9%. Conclusions: The MMU model is a feasible strategy to manage geriatric urgencies, especially involving the cardiorespiratory system, is associated with good outcomes and may prevent ED visits.
Secondary Microsurgical Reconstruction of the Cervical Esophagus: Safer Flaps and Practical Tips in a Challenging Situation
Authors: Ramella Vittorio , Ferrari Andrea , Novati Federico Cesare , Arnež Zoran Marij , Marchi Grace , Rodda Agostino , Bottosso Stefano , Papa Giovanni
Published: May 2024

Background: Cervical esophageal reconstruction is vital to improve the quality of life in cancer surgery patients. Microsurgery is crucial in providing vascularized tissue for defect repair, particularly in secondary cases with a higher risk of failure due to larger defects and damage from previous surgery and radiotherapy. The purpose of this study was to describe the clinical characteristics of a series of patients who underwent secondary repair of esophageal defects and provide practical information for the management and treatment of such cases based on the authors’ experience and the literature review. Methods: We retrospectively reviewed the electronic medical records of the Plastic Surgery Clinic at the University of Trieste to identify cases of patients who underwent secondary esophageal microsurgical reconstructions following oncological surgery. Patient demographics, the etiology of esophageal defects, previous surgical history, and preoperative assessments were collected from medical records. Surgical techniques utilized for reconstruction, such as pedicled flaps or free tissue transfers, were documented along with intraoperative information. Postoperative outcomes, including complications, graft viability, and functional outcomes, were evaluated during follow-up. Results: We treated 13 cases of secondary esophageal reconstructions between 2011 and 2022. Most commonly, Antero-Lateral Thigh (ALT) flaps were used in 10 cases, while 2 cases employed a radial forearm flap (RFF), and 1 case employed a chimeric parascapular flap. No flap failures occurred during a median 50-month follow-up. One ALT flap patient experienced postop stricture but maintained swallowing ability. A single tracheoesophageal fistula occurred in an RFF patient with a history of radiotherapy and complete lymph node dissection. Conclusions: Cervical esophageal reconstruction significantly impacts patients’ quality of life by restoring oral feeding and phonation. When local flaps fall short, microsurgical reconstruction with intestinal flaps is valuable but is burdened by limitations. For challenging secondary cases, ALT or RFF flaps emerge as safer options due to their robust pedicles, yielding low complication rates and positive functional outcomes.
Understanding Patterns of Adherence to Antifibrotic Treatment in Idiopathic Pulmonary Fibrosis: Insights from an Italian Prospective Cohort Study
Authors: Iommi Marica , Gonnelli Francesca , Bonifazi Martina , Faragalli Andrea , Mei Federico , Pompili Marco , Carle Flavia , Gesuita Rosaria
Published: May 2024

Background: Pirfenidone and Nintedanib have significantly improved the prognosis of patients with idiopathic pulmonary fibrosis (IPF), reducing mortality risk and exacerbations. This study aimed to analyze antifibrotic treatment utilization and its association with clinical outcomes (i.e., acute exacerbation or death) during 2014–2021 in newly diagnosed IPF patients, using Healthcare Utilization Databases of the Marche Region, Italy. Methods: The first 12-month adherence to antifibrotic was estimated using the Proportion of Days Covered (PDC), defining adherence as PDC ≥ 75%. State Sequence Analysis over the initial 52 weeks of treatment was used to identify adherence patterns. The role of adherence patterns on acute exacerbations/death, adjusted by demographic, clinical features, and monthly adherence after the 52-week period (time-dependent variable), was assessed with Cox regression. Results: Among 667 new IPF cases, 296 received antifibrotic prescriptions, with 62.8% being adherent in the first year. Three antifibrotic utilization patterns emerged—high adherence (37.2%), medium adherence (42.5%), and low adherence (20.3%)—with median PDCs of 95.3%, 79.5%, and 18.6%, respectively. These patterns did not directly influence three-year mortality/exacerbation probability, but sustained adherence reduced risk over time. Conclusions: Good adherence was observed in in this population-based study, emphasizing the importance of continuous antifibrotics therapy over time to mitigate adverse outcomes.
Energy-Efficient Resource Optimization for IRS-Assisted VLC-Enabled Offshore Communication System
Authors: Xu Woping , Gu Li
Published: May 2024

In this paper, a downlink energy efficiency maximization problem is investigated in an intelligent reflective surface (IRS)-assisted visible light communication system. In order to extend wireless communication coverage of the onshore base station, an IRS mounted on a unmanned aerial vehicle (UAV) is introduced to assist an onshore lighthouse with simultaneously providing remote ship users wireless communication services and illumination. Aiming to maximizing the energy efficiency of the proposed system, a resource allocation problem is formulated as the ratio of the achievable system sum rate to the total power consumption under the constraints of the user’s data requirement and transmit power budget. Due to the non-convexity of the proposed problem, the Dinkelbach method and mean-square error (MSE) method are adopted to turn the non-convex origin problem into two equivalent problems, namely transmit beamforming and reflected phase shifting. The Lagrangian method and semidefinite relaxation technique are used to obtain the closed-form solutions of these two subproblems. Accordingly, an alternative optimization-based resource allocation scheme is proposed to obtain the optimal system energy efficiency. The simulation results show that the proposed scheme performs better in terms of energy efficiency over benchmark schemes.
Marine Renewable-Driven Green Hydrogen Production toward a Sustainable Solution and a Low-Carbon Future in Morocco
Authors: Taroual Khadija , Nachtane Mourad , Rouway Marwane , Tarfaoui Mostapha , Faik Abdessamad , Mînzu Viorel , Hilmi Karim , Saifaoui Dennoun
Published: May 2024

Oceanic energy sources, notably offshore wind and wave power, present a significant opportunity to generate green hydrogen through water electrolysis. This approach allows for offshore hydrogen production, which can be efficiently transported through existing pipelines and stored in various forms, offering a versatile solution to tackle the intermittency of renewable energy sources and potentially revolutionize the entire electrical grid infrastructure. This research focusses on assessing the technical and economic feasibility of this method in six strategic coastal regions in Morocco: Laayoune, Agadir, Essaouira, Eljadida, Casablanca and Larache. Our proposed system integrates offshore wind turbines, oscillating water column wave energy converters, and PEM electrolyzers, to meet energy demands while aligning with global sustainability objectives. Significant electricity production estimates are observed across these regions, ranging from 14 MW to 20 MW. Additionally, encouraging annual estimates of hydrogen production, varying between 20 and 40 tonnes for specific locations, showcase the potential of this approach. The system’s performance demonstrates promising efficiency rates, ranging from 13% to 18%, while maintaining competitive production costs. These findings underscore the ability of oceanic energy-driven green hydrogen to diversify Morocco’s energy portfolio, bolster water resilience, and foster sustainable development. Ultimately, this research lays the groundwork for comprehensive energy policies and substantial infrastructure investments, positioning Morocco on a trajectory towards a decarbonized future powered by innovative and clean technologies.
Gulf Stream Effects on Sea Level Oscillations: Enhancing Performance of a Coastal and Estuarine Model Nested into Global Model through Modified Boundary Conditions
Authors: Habib Md Ahsan , Zarillo Gary A.
Published: May 2024

This study investigates the effects of the gulf stream (GS) on sea-level oscillations across various time scales and assesses the performance of a coastal and estuarine model nested within a global model in simulating these variations. It aims to improve boundary conditions to simulate sea-level oscillations more accurately by considering the influence of GS flow. An inverse correlation is observed between observed sea-level oscillation and GS flow, which becomes more pronounced over longer time scales. Using Delft3D, a high-resolution coastal and estuarine model is developed to simulate circulation dynamics in the central Indian River Lagoon (IRL), FL, and adjacent coastal areas on the Florida east coast. The model is nested into the HYCOM (Hybrid Coordinate Ocean Model), and meteorological forcings are derived from the NARR (North American Regional Reanalysis) model. The model demonstrates satisfactory performance across key parameters, including tide, salinity, water temperature, and currents. However, there remains a noticeable difference between the modeled and observed data. To address this, the model is executed with modified flow boundary conditions at eastern boundary nodes, integrating HYCOM tide, and observing low-frequency sea-level variations. The implementation of the new boundary conditions results in an improved simulation of sea-level oscillations. This study presents the conceptual framework and detailed methodologies employed in the creation of a high-resolution model tailored for estuarine and coastal areas nested into global models capable of satisfactorily simulating sea-level oscillations even when the global model does not represent GS effects.
Endophytic Fungi Volatile Organic Compounds as Crucial Biocontrol Agents Used for Controlling Fruit and Vegetable Postharvest Diseases
Authors: Ling Lijun , Feng Lijun , Li Yao , Yue Rui , Wang Yuanyuan , Zhou Yongpeng
Published: May 2024

Fruits and vegetables are an important part of the human diet, but during transportation and storage, microbial pathogens attack and spoil fruits and vegetables, causing huge economic losses to agriculture. Traditionally used chemical fungicides leave chemical residues, leading to environmental pollution and health risks. With the emphasis on food safety, biocontrol agents are attracting more and more attention due to their environmental friendliness. Endophytic fungi are present in plant tissues and do not cause host disease. The volatile organic compounds (VOCs) they produce are used to control postharvest diseases due to their significant antifungal activity, as well as their volatility, safety and environmental protection characteristics. This review provides the concept and characterization of endophytic fungal VOCs, concludes the types of endophytic fungi that release antifungal VOCs and their biological control mechanisms, as well as focuses on the practical applications and the challenges of applying VOCs as fumigants. Endophytic fungal VOCs can be used as emerging biocontrol resources to control postharvest diseases that affect fruits and vegetables.
Gut Mycobiome in Atopic Dermatitis and in Overweight Young Children: A Prospective Cohort Study in Finland
Authors: Vänni Petri , Turunen Jenni , Äijälä Ville K. , Tapiainen Vilja V. , Paalanne Marika , Pokka Tytti , Paalanne Niko , Tejesvi Mysore V. , Ruuska Terhi S.
Published: May 2024

Gut bacterial alterations have been previously linked to several non-communicable diseases in adults, while the association of mycobiome is not well understood in these diseases, especially in infants and children. Few studies have been conducted on the association between gut mycobiome and non-communicable diseases in children. We investigated gut mycobiome composition using 194 faecal samples collected at birth, 6 months after birth, and 18 months after birth in relation to atopic dermatitis (AD) and overweight diagnoses at the age of 18 or 36 months. The mycobiome exhibited distinct patterns, with Truncatella prevalent in the meconium samples of both overweight and non-overweight groups. Saccharomyces took precedence in overweight cases at 6 and 18 months, while Malassezia dominated non-overweight samples at 6 months. Saccharomyces emerged as a consistent high-abundance taxon across groups that had dermatitis and were overweight. We found a weak association between gut mycobiome and AD at birth and overweight at 18 months when using machine learning (ML) analyses. In ML, unidentified fungi, Alternaria, Rhodotorula, and Saccharomyces, were important for classifying AD, while Saccharomyces, Thelebolus, and Dothideomycetes were important for classifying overweight. Gut mycobiome might be associated with the development of AD and overweight in children.
Resilient Stress Reactivity Profiles Predict Mental Health Gains from Online Contemplative Training: A Randomized Clinical Trial
Authors: Godara Malvika , Singer Tania
Published: May 2024

Low-dose app-based contemplative interventions for mental health are increasingly popular, but heterogeneity in intervention responses indicates that a personalized approach is needed. We examined whether different longitudinal resilience–vulnerability trajectories, derived over the course of the COVID-19 pandemic, predicted differences in diverse mental health outcomes after mindfulness and socio-emotional dyadic online interventions. The CovSocial project comprised a longitudinal assessment (phase 1) and an open-label efficacy trial (phase 2). A community sample of 253 participants received 12 min daily app-based socio-emotional dyadic or mindfulness-based interventions, with weekly online coaching for 10 weeks. Before and after the intervention, participants completed validated self-report questionnaires assessing mental health. Stress reactivity profiles were derived from seven repeated assessments during the COVID-19 pandemic (January 2020 to March/April 2021) and were categorized into resilient (more plasticity) or vulnerable (less plasticity) stress recovery profiles. After both interventions, only individuals with resilient stress reactivity profiles showed significant improvements in depression symptomatology, trait anxiety, emotion regulation, and stress recovery. Those with vulnerable profiles did not show significant improvements in any outcome. Limitations of this study include the relatively small sample size and potential biases associated with participant dropout. Brief app-based mental interventions may be more beneficial for those with greater levels of stress resiliency and plasticity in response to stressors. More vulnerable individuals might require more intense and personalized intervention formats.
Can Crisis Periods Affect the ESG Reporting Scope? The Portuguese Euronext Entities Case
Authors: Cepeda Catarina
Published: May 2024

Portuguese companies are increasingly responding to the demand of stakeholders for transparent information about companies’ environmental, social, and governance (ESG) performance by issuing non-financial reports (NFRs). While the number of NFRs published annually has been increasing over the last two decades, their quality and companies’ ESG performance have been questioned, especially in times of crisis. To address these concerns, several jurisdictions have introduced mandatory NFR rules, such as the European Directive 2014/95/EU. Employing an institutional theory lens, this paper’s research objective is to evaluate whether the last decade’s crises and whether the fact that NFRs became mandatory for certain entities positively affected companies’ activities covered in the ESG reporting scope. We used panel data regression models on 45 listed companies in Portugal during the period 2008–2021. Our results show that the ESG reporting scope is not positively influenced by the transition from NFRs to a mandatory and global financial crisis (GFC). However, the COVID-19 crisis positively affected NFR quality. These results have major implications for practitioners, reflecting the importance of promoting these tools in an organization to improve non-financial performance and companies’ sustainability.
Spatial-Temporal Heterogeneity and Decoupling Mechanism of
Resource Curse, Environmental Regulation and Resource
Industry Transformation in Post-Development Areas: Evidence
from Inner Mongolia, China
Authors: Liu Mingkai , Zhang Hongyan , Liu Changxin , Gong Xiaoju
Published: May 2024

Resource curse and environmental regulation are the key bottlenecks that hinder the sustainable development of the resource industry. A reasonable assessment of the decoupling relationship between resource supply, environment regulation and resource industry transformation is helpful to promote the decision-making of industrial restructuring in post-development regions. Taking Inner Mongolia Autonomous Region of China as the research object, panel data related to resources, environment and industry from 2010 to 2021 are selected to evaluate the spatial and temporal evolution of regional resource supply security, environmental regulatory pressure and resource industry transformation efficiency, measure the decoupling index among the factors, and use geographic detector technology to identify the constraints affecting factor decoupling. The results show the following: (1) the resource curse effect of Inner Mongolia is not significant, and some resource industries have prominent advantages; (2) the security of resource supply and the transformation efficiency of the resource industry show overall upward trend, the pressure of environmental regulation is basically balanced, and the development level of factors in resource-endowed regions and central cities is relatively high; (3) the spatial and temporal evolution of the decoupling relationship between resource supply, environmental regulation and resource industry transformation is uncertain, and the resilience of regional economic and social governance is poor; (4) resource endowment and resource industry advantages are the key that restricts the decoupling of factors, and the cumulative effect of ecological governance is likely to lead to the randomness of the decoupling of environmental regulation and resource industry transformation. In addition, this study suggests that the post-development areas should pay attention to the classification of resource industry relief, trans-regional economic and social collaborative governance and special resources exploitation.
Establishing Boundaries to Combat Tax Crimes in Indonesia
Authors: Nurferyanto Dwi , Takahashi Yoshi
Published: May 2024

Enforcing criminal tax law in Indonesia presents a critical yet challenging task, because of the intricate interplay between tax and criminal law interests. The Indonesian Government has introduced leniency in tax criminal law enforcement, guided by the ultimum remedium principle, where criminal sanctions are considered as a last resort. Under this policy, tax offenders can absolve themselves from legal liability. However, such leniency throughout the enforcement process can lead to perceptions of injustice within society. This research uses descriptive, evaluative, and normative juridical methods to examine Indonesia’s approach to enforcing criminal tax laws within the framework of tax and legal interests. Our findings reveal that the current policies heavily favor taxpayer interests by providing numerous concessions to offenders. This trend is concerning, as it may result in a surge of tax crime cases. Conversely, adopting the primum remedium principle, where criminal sanctions are the initial response, poses the risk of harsh legal consequences. In light of these challenges, we propose a balanced approach incorporating elements of both ultimum and primum remedium principles to establish clear boundaries and provisions within criminal tax law enforcement policies. By doing so, we aim to accommodate tax interests while upholding legal interests.
Autocatalytic Selection as a Driver for the Origin of Life
Authors: Williamson Mike P.
Published: May 2024

Darwin’s theory of evolution by natural selection was revolutionary because it provided a mechanism by which variation could be selected. This mechanism can only operate on living systems and thus cannot be applied to the origin of life. Here, we propose a viable alternative mechanism for prebiotic systems: autocatalytic selection, in which molecules catalyze reactions and processes that lead to increases in their concentration. Crucially, this provides a driver for increases in concentrations of molecules to a level that permits prebiotic metabolism. We show how this can produce high levels of amino acids, sugar phosphates, nucleotides and lipids and then lead on to polymers. Our outline is supported by a set of guidelines to support the identification of the most likely prebiotic routes. Most of the steps in this pathway are already supported by experimental results. These proposals generate a coherent and viable set of pathways that run from established Hadean geochemistry to the beginning of life.
Impact of Intermittent Hypoxia Related to Obstructive Sleep Apnoea Syndrome on Low-Grade Inflammation in Hypertensive Patients: Potential Implications for Cardiovascular Risk
Authors: Hein Matthieu , Wacquier Benjamin , Conenna Matteo , Lanquart Jean-Pol , Point Camille
Published: May 2024

There is evidence for a particular relationship between low-grade inflammation (LGI) and intermittent hypoxia (IH) related to obstructive sleep apnoea syndrome (OSAS). However, despite the potential deleterious cardiovascular consequences associated with this LGI in hypertensive patients, few studies have investigated the impact of IH related to OSAS on CRP levels in this subpopulation. In total, 1404 hypertensive patients were selected retrospectively from the Sleep Laboratory database. CRP levels ≥3 mg/L but <10 mg/L were used as cut-offs to identify hypertensive patients with LGI. Logistic regressions were conducted to examine the risk of LGI associated with IH related to OSAS in hypertensive patients. LGI was frequent (33.8%) in hypertensive patients. After adjustment for confounders, multivariate logistic regressions revealed that only moderate to severe OSAS (apnoea–hypopnoea index ≥ 15/h) with high IH (oxygen desaturation index ≥ 15/h) [OR 1.51 (95% CI 1.06–2.14)] was significantly associated with LGI in hypertensive patients (p-value = 0.045). Consistent with our hypothesis, our results demonstrated the existence of a particular subtype of hypertensive patients at high cardiovascular risk characterised by the presence of LGI induced by IH hypoxia related to moderate to severe OSAS, which justifies the establishment of adequate management of this pathology to allow better cardiovascular prevention in this subpopulation.
Influence of Nanoparticles in Lubricant on Sliding Contact of Atomic Rough Surfaces—A Molecular Dynamics Study
Authors: Zheng Xuan , Su Lihong , Deng Guanyu
Published: May 2024

In this work, large-scale molecular dynamics (MD) computational simulations were performed in order to explore the sliding contact responses of rough surfaces with hexadecane lubricant and added nanoparticles. Simulation results revealed that the frictional state was dependent on the fluid, nanoparticle, and surface roughness. Three lubricating conditions were compared based on considerations of different amounts of fluid molecules. The lubricant was not able to separate the frictional contact surfaces if the quantity of lubricant molecules was insufficient. Particularly, there were no lubricating contributions when the amount of lubricant was too low, and the lubricant therefore only filled the pits in the surface roughness. Thus, the normal load was primarily supported by the contact between the two surfaces and nanoparticles, leading to significant surface morphology changes. In contrast, the frictional contact surfaces were able to be completely separated by the lubricant when there was a sufficient amount of fluid, and a very good lubricating effect could thus be achieved, resulting in a smaller friction force. In addition, the changes in surface morphology, contact area, and RMS are discussed in this paper, in order to reveal the dynamic frictional process.
Research on Sudden Unbalance Response of Rigid-Elastic-Oil Coupled Ball Bearings
Authors: Li Yan , Cui Yongcun , Deng Sier
Published: May 2024

(1) Background: To better understand the dynamic characteristics of a ball bearing with an elastic ring squeeze film damper (ERSFD) under sudden unbalance, a novel dynamic model was established by fully considering the coupling between the ERSFD, bearing outer ring (the journal), rotor, and disc (loading bearing); (2) Methods: An improved secant method was developed to determine the initial eccentricity values of the bearing’s outer ring and the disc. The dynamic response of the outer ring under different speed ratios, damping ratios, and mass ratios was solved using the variable-step Runge–Kutta method; (3) Results: In comparison, a low-speed ratio, high damping ratio, and low mass ratio were more conducive to suppressing the bearing vibration. When the imbalance was suddenly introduced, the displacement amplitude of the eccentricity, transmissibility, amplitude–frequency response, and the radius of the outer ring center locus increased; (4) Conclusions: This work provides a reference for further studying the nonlinear vibration of rolling bearings coupled with an ERSFD.
Di-µ-(1-(3-(1H-imidazol-1-yl)propyl)-2-methyl-4-oxo-1,4-dihydropyridin-3-olate)-bis[(η5-pentamethylcyclopentadienyl)iridium(III)] Chloride
Authors: Shutkov Ilya A. , Melnichuk Nikolai A. , Lyssenko Konstantin A. , Borisova Nataliya E. , Kovaleva Olga N. , Nazarov Alexey A.
Published: May 2024

A metallacyclic maltol-tethered organometallic Ir(III) half-sandwich complex was synthesized as an analog of the ruthenium anticancer complexes (RAPTA/RAED) to evaluate its in vitro antiproliferative activity against various human cancer cell lines.
Quantum Dot Research in Breast Cancer: Challenges and Prospects
Authors: Omidian Hossein , Wilson Renae L. , Cubeddu Luigi X.
Published: May 2024

The multifaceted role of quantum dots (QDs) in breast cancer research highlights significant advancements in diagnostics, targeted therapy, and drug delivery systems. This comprehensive review addresses the development of precise imaging techniques for early cancer detection and the use of QDs in enhancing the specificity of therapeutic delivery, particularly in challenging cases like triple-negative breast cancer (TNBC). The paper also discusses the critical understanding of QDs’ interactions with cancer cells, offering insights into their potential for inducing cytotoxic effects and facilitating gene therapy. Limitations such as biocompatibility, toxicity concerns, and the transition from laboratory to clinical practice are critically analyzed. Future directions emphasize safer, non-toxic QD development, improved targeting mechanisms, and the integration of QDs into personalized medicine, aiming to overcome the current challenges and enhance breast cancer management.
Analysis of Mechanical Properties of Fiber-Reinforced Soil Cement Based on Kaolin
Authors: Zhao Junnan , Zong Zhongling , Cen Hang , Jiang Pai
Published: May 2024

Adding fibers into cement to form fiber-reinforced soil cement material can effectively enhance its physical and mechanical properties. In order to investigate the effect of fiber type and dosage on the strength of fiber-reinforced soil cement, polypropylene fibers (PPFs), polyvinyl alcohol fibers (PVAFs), and glass fibers (GFs) were blended according to the mass fraction of the mixture of cement and dry soil (0.5%, 1%, 1.5%, and 2%). Unconfined compressive strength tests, split tensile strength tests, scanning electron microscopy (SEM) tests, and mercury intrusion porosimetry (MIP) pore structure analysis tests were conducted. The results indicated that the unconfined compressive strength of the three types of fiber-reinforced soil cement peaked at a fiber dosage of 0.5%, registering 26.72 MPa, 27.49 MPa, and 27.67 MPa, respectively. The split tensile strength of all three fiber-reinforced soil cement variants reached their maximum at a 1.5% fiber dosage, recording 2.29 MPa, 2.34 MPa, and 2.27 MPa, respectively. The predominant pore sizes in all three fiber-reinforced soil cement specimens ranged from 10 nm to 100 nm. Furthermore, analysis from the perspective of energy evolution revealed that a moderate fiber dosage can minimize energy loss. This paper demonstrates that the unconfined compressive strength test, split tensile strength test, scanning electron microscopy (SEM), and mercury intrusion porosimetry (MIP) pore structure analysis offer theoretical underpinnings for the utilization of fiber-reinforced soil cement in helical pile core stiffening and broader engineering applications.
Molybdenum-Doped ZnO Thin Films Obtained by Spray Pyrolysis
Authors: Bancheva-Koleva Pavlina , Zhelev Veselin , Petkov Plamen , Petkova Tamara
Published: May 2024

A batch of ZnO thin films, pure and doped with molybdenum (up to 2 mol %), were prepared using the spray pyrolysis technique on glass and silicon substrates. The effect of molybdenum concentration on the morphology, structure and optical properties of the films was investigated. X-ray diffraction (XRD) results show a wurtzite polycrystalline crystal structure. The average crystallite size increases from 30 to 80 nm with increasing molybdenum content. Scanning electron microscopy (SEM) images demonstrate a smooth and homogeneous surface with densely spaced nanocrystalline grains. The number of nuclei increases, growing over the entire surface of the substrate with uniform grains, when the molybdenum concentration is increased to 2 mol %. The estimated root mean square (RMS) roughness values for the undoped and doped with 1 mol % and 2 mol % of ZnO thin films, defined by atomic force microscopy (AFM), are 6.12, 23.54 and 23.83 nm, respectively. The increase in Mo concentration contributes to the increase in film transmittance.
Transformation of Coherent Twin Boundary into Basal-Prismatic Boundary in HCP-Ti: A Molecular Dynamics Study
Authors: Sun Tao , Bao Qili , Gao Yang , Li Shujun , Li Jianping , Wang Hao
Published: May 2024

The manufacturing process for wrought Ti alloys with the hexagonal close-packed (HCP) structure introduces a complicated microstructure with abundant intra- and inter-grain boundaries, which greatly influence performance. In the hexagonal close-packed (HCP) structure, two types of grain boundaries are commonly observed between grains with ~90° misorientation: the basal/prismatic boundary (BPB) and the coherent twin boundary (CTB). The mechanical response of the BPB and CTB under external loading was studied through molecular dynamic simulations of HCP-Ti. The results revealed that CTB undergoes transformation into BPB through the accumulation of twin boundary (TB) steps and subsequent emission of Shockley partial dislocations. When the total mismatch vector is close to the Burgers vector of a Shockley partial dislocation, BPB emits partial dislocations and further grows along the stacking faults. When a pair of CTBs are close to each other, severe boundary distortion occurs, facilitating the emission and absorption of partial dislocations, which further assists the CTB-BPB transformation. The present results thus help to explain the frequent observation of coexisting CTB and BPB in HCP alloys and further contribute to the understanding of their microstructure and property regulation.
Study on the Parameter Influences of Gear Tooth Profile Modification and Transmission Error Analysis
Authors: Zhou Di , Guo Yonglin , Yang Jian , Zhang Yimin
Published: May 2024

Gear transmission systems are widely used to transfer energy and motion and to guarantee the accuracy of the entire machine system. The modification technique is a common method that improves the gear profile and reduces the transmission error. Based on the parametric model, a modified gear can be established for the evaluation of static and dynamic characteristics. The influences of profile modification parameters and gear parameters are investigated while changing the rules of different kinds of factors. Based on sensitive parameters, a two-stage profile modification curve is proposed to improve the performance of gear pairs. Thus, considering the time-varying mesh stiffness and backlash, a novel, dynamic modified gear model is established to analyze the dynamic performance, such as the dynamic transmission error. Based on the proposed curve, the range and amplitude of the transmission error can be decreased. Additionally, the vibration displacement and noise can be reduced to improve the running characteristics.