bluuebunny/crossref_metadata_2025 huggingface dataset:
Innovation, Global Competitiveness and Human Development Index: EU Cluster Case
Authors: Çetin Melike
Published: October 2024

This study investigates the effects of innovation on global competitiveness within the framework of the EU13 and EU15 countries. Using a Pooled Driscoll and Kraay regression analysis that takes into account unit and time effects, the research illuminates the relationship between the Human Development Index (HDI), which represents Global Competitiveness, Research Expenditure, the Number of Researchers, the Number of Patents, and the Human Capital Index. The findings reveal that while the number of researchers and research expenditure lack a statistically significant effect on HDI in both groups, a significant positive correlation was found between HDI and both the number of patents and human capital. More specifically, for EU13 countries, an increase in the number of patents and human capital leads to respective increases of 0.005 and 0.04 in the HDI, while for EU15 countries, these figures stand at 0.0008 and 0.03 respectively. The study concludes that investment strategies aimed at enhancing human capital and increasing the number of patent applications can notably improve global competitiveness. For EU13 countries, in particular, greater effort in the mentioned areas is needed to narrow the gap with their EU15 counterparts. In addition, despite the indirect impact on competitiveness, it is recommended for EU13 countries to boost their R&D investments and foster technological transfer to enhance their innovation capabilities. The findings from this study underscore the pivotal role of innovation in achieving global competitiveness and suggest a need for stronger collaboration within the European Union, particularly in scientific and technological fields, to facilitate knowledge and skill exchange.
Contributing to Gastrodiplomacy through Culinary Experience: A Cooking Event in Spain
Authors: Ozel Meltem , Filiz Şeyma
Published: October 2024

It is utilized by governments as a potent strategy for building and cultivating contacts with other countries and cultures, as well as contributing to nation branding through gastrodiplomacy, culinary arts, and public diplomacy. Within the framework of public diplomacy, gastrodiplomacy—also known as culinary diplomacy—can be characterized as the transfer of culture through the kitchen. In the context of gastrodiplomacy and nation branding, the study focuses on gastronomic experiences that highlight the distinctive qualities of a nation. The article will also refer to the work of Carmen Antón, which emphasizes the term 'culinary experience' to discuss the concept and focuses on travelers' unforgettable gastronomy experiences. The study examines the culinary experiences of academics from several countries in Spain between February 28 and March 4, 2022. Consequently, it aims to establish how the culinary experience contributes to Spain's nation branding and gastrodiplomacy.
Példaszerű kisebbségvédelem
Authors: Jeszenszky Géza
Published: October 2024

Komac, Miran − Vizi Balázs (szerk.): Bilaterális kisebbségvédelem: A magyar-szlovén kisebbségvédelmi egyezmény háttere és gyakorlata. Budapest: L’ Harmattan Kiadó, 2019. 348 oldal
A Muravidék sorsdöntő hónapjai
Authors: Dévavári Zoltán
Published: October 2024

Göncz László: A Muravidék útja a délszláv királyságba. A tájegység története az első világháború végétől a jugoszláv megszállásig (1918 ősze – 1919 augusztusa). Szombathely–Ljubjana–Lendva: Magyar Nyugat Könyvkiadó – Inštitut za narodnostna vprašanja – Magyar Nemzetiségi Művelődési Intézet, 2024. 563 oldal
Elitek, mindennapi emberek és átmenetek – a sűrű otthonosság és olvasatai
Authors: Szabó Á. Töhötöm
Published: October 2024

Borbély Sándor: Informális gyakorlatok. Hétköznapi gazdasági és politikai cselekvések Kárpátalja határvidéki régiójában. Budapest: L’Harmattan Kiadó, 2023. 330 oldal
Exploration of Factors Affecting Pro-social Intention to Disclose Information in Healthcare Settings
Authors: Chun Kyunghee , Park Young-soon , Cho Young Jun , Lee You Jung
Published: October 2024

This study investigated the relationships of situational factors, motivational assessment–related factors, and situationally induced personal characteristics with pro-social intention to disclose patient information among health and medical students. In total, 210 students from Konyang University participated in the survey, including 116 medical students and 94 other health students. To measure the influence of variables on pro-social intention to disclose information related to health information security, a 27-item questionnaire was used. The reliability of the survey was shown by Cronbach’s α values of 0.859 to 0.917. According to students’ perceptions, higher disease severity was significantly related to higher impacts on the patient, family, and themselves (p<0.01), as well as higher situational empathy (p<0.05). Pro-social intention to disclose showed negative correlations with health information security awareness, information education experience, perceived impact on the self, responsibility to disclose, and personal norms (r=-0.136 to -0.647, p<0.05). Responsibility to disclose and situational empathy explained approximately 44% of the variance in pro-social intention to disclose. Additionally, students who received information security training perceived a significantly higher responsibility to disclose, exhibited higher health information security awareness, and had lower pro-social intention to disclose. This study confirmed the need for information security education for health and medical students, and suggested that pro-social characteristics such as empathy and responsibility need to be carefully addressed in information security education.
A Comparison of Medical Education Policies in Japan and Singapore with a Focus on Governance: Implications for Korea
Authors: Jung Sung-Soo
Published: October 2024

Among Asian nations, Japan, Singapore, and South Korea exemplify countries with high standards of medical quality. This review explores the differences in medical education policies between Japan and Singapore, particularly concerning governance, and discusses the implications for South Korea’s medical education policies. Relevant documents were analyzed by referencing scholarly articles and data from governmental and expert organizations in each country. In Japan, advances in medical education policies include initiatives such as the regional quota system and the core curriculum model, which emphasize stakeholder engagement and transparency. However, challenges persist due to limited stakeholder participation, necessitating a transition toward a more equitable governance paradigm. Singapore’s model features robust public-private partnerships with minimal direct governmental intervention, emphasizing innovation and community integration, as seen in the Healthier SG project. These case studies demonstrate effective governance involving significant stakeholder collaboration and strategic financial investments. Conversely, South Korea’s medical education policies face challenges from a predominantly government-centric approach, with an absence of cohesive governance structures and inadequate involvement from essential professional stakeholders. This situation has led to policy inconsistencies and a deficit of strategic direction, exacerbated by insufficient financial support for educational infrastructure and program development. The experiences of Japan and Singapore indicate that it would be beneficial for South Korea to adopt integrated governance frameworks that prioritize transparency and collaboration. Furthermore, increasing financial investment in medical education could mitigate existing deficiencies and improve the quality and effectiveness of its healthcare education system.
SDS-PAGE and immunoblotting to assess whole-cell lysates from cell culture systems v1
Authors: V Hundley Frances , A. Gonzalez-Lozano Miguel , Kraus Felix , JW Harper
Published: October 2024

This is a general protocol for Western blotting to detect proteins or interest from whole-cell lysates derived from cell culture systems (HeLa, iNeurons).
Phytolith Reference Collection Processing - Dry Ashing v1
Authors: R Wade Kali
Published: October 2024

This protocol is designed to clean, dry ash, wash with acid, and mount modern plant specimens onto slides as phytolith reference comparisons. The procedure is adapted from Pearsall (2015: 294) and Piperno (2006: 97) and takes approx. 4 days to complete.
RNA-seq for human iPSC-CM following GSK3 inhibition v1
Authors: Anglen Taylor , M. Kaplow Irene , Choi Baekgyu , Hagy Kevin , Tran Duc , E. Ramaker Magan , Barrera Alejandro , Shah Svati , Jung Inkyung , Karra Ravi , Diao Yarui , A. Gersbach Charles
Published: October 2024

This protocol describes RNA-seq methods in human iPSC-CM following growth with or without GSK3 inhibition using CHIR99021.
Vertebrate Clearing and Staining - 'VCaS' Protocol v2
Authors: E. Ryan Sidney , Mia Ehler Kara , M Giudici Christina , E. Stuart Yoel , Niccolo Cerasoni Jacopo
Published: October 2024

Small vertebrates can be stained and cleared using a trypsin enzyme, Alcian blue, and Alizarin red stains. The process is completed over several weeks and the final product allows clear viewing of internal structures including bone and cartilage. Cleared and stained vertebrate specimen can be used for educational or scientific purposes. Final products are stored in pure glycerin for an indefinite amount of time and can be viewed over a light box when needed.
An adaptable protocol for antibody & TDP-43 RNA aptamer dual immunohistochemical staining for FFPE-preserved human tissue: with SOP and tick-sheet. v1
Authors: M Waldron Fergal , Gregory Jenna
Published: October 2024

Here we provide a protocol with SOP and tick-sheet, for correct procedures to dual stain FFPE human tissue for, 1) pathological TDP-43 protein, along with 2) any other protein of interest, with the aim of visualising protein of interest histology in the context of TDP-43 pathology. This method utilises a published TDP-43 RNA aptamer (biotinylated)(Spence and Waldron, 2024 in Acta Neuropathologica here https://link.springer.com/article/10.1007/s00401-024-02705-1) which detects pathological TDP-43 with greater sensitively and specificity than with current antibody approaches. This protocol can be implemented for dual staining of any rabbit or mouse primary detection antibody (using the Novolink Polymer Detection System), and with our TDP-43 RNA aptamer (Spence and Waldron, 2024) The resulting dual stain will show brown chromogen (detecting the target of the primary antibody) with red chromogen(detecting TDP-43 pathology with our TDP-43 RNA aptamer). Reference for citation of this method To cite this dual staining method, please cite Waldron and Gregory, 2024 (here) published on protocols.io: An adaptable protocol for antibody & TDP-43 RNA aptamer dual immunohistochemical staining forFFPE-preserved human tissue: A SOP and tick-sheet. Fergal M. Waldron‡, Jenna M. Gregory‡, (2024). Protocols.io 2024; DOI: dx.doi.org/10.17504/protocols.io.yxmvm97k6l3p/v1 ‡equal contributions and co-corresponding authors
Moving Margins: Writing in Relation as Liberatory Practice
Authors: Hamzah Saba , Aparna Kolar
Published: October 2024

This article is a practice of writing in relation. We consciously keep the conversational format to be close to our practice as educators, migrant‐artists, and scholars. We weave our personal journeys as political and urgent for epistemic justice on questions of social inclusion of (forced) migrants. We do so to question the dominant forms of inclusion practiced in institutions that our bodies have navigated and continue to do so. Our intention is to open rather than fix our approach of relational biographical writing to bring attention to some hidden forms of daily violence and paradoxes challenging the path of emancipatory practice within spaces claiming social inclusion of migrants/refugees. We reflect on why we write and why we came to academia, inviting the reader to journey with us in what we experience as moving margins.
Narrating Solidarity With Ukraine: European Parliament Debates on Energy Policy
Authors: Theiss Maria , Menshenina Anna
Published: October 2024

The article aims to improve our understanding of the politics of energy policy in the EU in the context of the war in Ukraine. It shows how the energy policy debate is contextualised by the suffering of Ukraine and the country’s efforts to resist Russian aggression and full-scale war. An abductive qualitative content analysis of 10 European Parliament debates on economic sanctions against Russia between March 2014 and October 2022 is used to reconstruct four narratives of the EU’s transnational solidarity with Ukraine. The following solidarity narratives are compared in terms of underlying notions of solidarity, proposed policy solutions, and their temporal aspects: “solidarity based on the common enemy,” “solidarity as mutual sacrifice,” “solidarity based on shared independence,” and “solidarity based on our resilience.” We find that despite the prominence of the solidarity frame in all four narratives, there were latent relevant differences in the urgency of the proposed solutions. Moreover, the references to suffering in these narratives tend to contrast “their” and “our” suffering, rather than calling for help for Ukraine.
The Potentials and Limitations of Agent-Based Models for Urban Digital Twins: Insights From a Surveillance and Behavioral Nudging Simulation
Authors: Shtaierman Sarah , Fontes Catarina , Lütge Christoph
Published: October 2024

Although urban digital twins are still at an embryonic stage of development, their use cases are multiple, ranging from big data aggregation to simulations. Additionally, predictions can be rendered and quickly implemented using actuators to transform physical environments and influence urban life. In this article, we investigate the potential of an agent-based model in a smart city setting to predict emergent behavior in relation to the suppression of civil violence by implementing crowd management practices. To this end, we designed a simulation environment that includes cameras in public spaces and wearable sensors, and considers nudging and self-nudging processes supported by a surveillance apparatus. Building on Epstein’s threshold-based model of civil violence, the proposed simulation is informed by surveillance theories and contemplates methods for crowd monitoring and social control. The experiments’ results provide insights into how specific measures and combined actions may influence the suppression of civil violence in public spaces and can be useful to inform crowd management activities and policymaking. Moreover, we use the simulation to reflect upon the potentials and limitations of integrating agent-based models into urban digital twins and emphasize the imminent risks for individuals and democratic societies of employing a ubiquitous surveillance apparatus endowed with the autonomy to trigger actuators.
Short-Term Transcultural Counseling: Personal Experiences, Cautions, and Considerations
Authors: Herod Leah A.
Published: October 2024

The number of mental health professionals volunteering their skills in transcultural counseling efforts is increasing. This article is tailored for U.S. counselors aspiring to initiate work overseas, particularly with nationals in non-Western cultures. Cautions and considerations, heavily informed by personal experience, are discussed and integrated with research. Fundamental aspects of preparation, personal assessment, and cultural factors, along with general comments about the process, are covered. More specifically, cultural research, humility, appropriateness, culturally adapted treatment, and cultural sensitivity are addressed, including working with interpreters. Ethical adaptations in regard to informed consent, records, and confidentiality are mentioned. A brief overview of implementation is discussed, including aspects of evaluation. This article aims to inspire counselors to embark on their first endeavor, fostering potential partnerships and collaborations that contribute to the global health movement and ultimately decrease the burden of mental illness worldwide.
Is it necessary to diagnose and correct vitamin D deficiency in malignant neoplasms? Analytical review
Authors: Shagina Natalya Y. , Obukhova Olga A. , Marinov Dimitar T. , Trifonova Maria S. , Ponomarev V. E.
Published: October 2024

BACKGROUND: Although the critical role of vitamin D in mineral homeostasis regulation is widely recognized, the global prevalence of vitamin D deficiency is exceedingly high. The substantial number of population-based studies that examine the correlation between the concentration of circulating vitamin D levels and the risk of developing cancer may be attributed to the growing interest of researchers in this vitamin as a suppressor of proliferating epithelial cells. However, the data collected are contradictory.
AIM: To ascertain the necessity of diagnosing and rectifying vitamin D deficiency in cancer patients.
MATERIALS AND METHODS: The keywords “vitamin D,” “vitamin D deficiency,” “cancer,” and “survival” were employed to identify publications in the e-Library, PubMed, and ScienceDirect databases from January 2014 to January 2024. Based on the data obtained, an analytical review of the literature was conducted.
RESULTS: The global prevalence of vitamin D deficiency, including among cancer patients, is exceedingly high and does not vary by sex, age, or ethnicity. Decreased serum vitamin D levels are linked to an elevated incidence of colorectal cancer, breast cancer, melanoma, prostate, and pancreatic cancer. Addressing vitamin D deficiency helped mitigate the risk of developing breast cancer. Data on the effect of vitamin D deficiency and its correction on patient survival are inconsistent.
CONCLUSION: Currently, there is no consensus regarding the impact of vitamin D supplementation on the incidence of diverse malignancies, as well as tumor-specific and overall survival. Additional research is required to address the necessity of diagnosing and correcting vitamin D deficiency.
A Proposal for a High-Frequency Earthquake Magnitude (m3Hz) for Seismic Hazard and Rapid Damage Assessment
Authors: Parolai Stefano , Spallarossa Daniele , Oth Adrien , Picozzi Matteo
Published: October 2024

Obtaining a size estimate of an earthquake that well represents its potential impact is of primary importance in seismology and earthquake engineering. The magnitude scales currently used in earthquake catalogs, mainly Ms and Mw, are not designed to represent the variability of shaking due to variations in high-frequency radiation. Conversely, ML, which best describes the seismic-wave energy released by an earthquake, is unable to provide an accurate representation of events with magnitudes exceeding approximately 6.5. Therefore, building on and extending the concept of high-frequency magnitude (Atkinson and Hanks, 1995), we propose in this article a new high-frequency magnitude scale m3Hz. This magnitude is estimated by also considering correction factors for the crustal model and site effects. We apply the new magnitude scale m3Hz to two data sets (Central Italy and Japan) and validate its ability to capture high-frequency radiation effects through comparison with available source parameters. Finally, a procedure for estimating m3Hz is also proposed for preinstrumental earthquakes. This procedure addresses a limitation of previous magnitude estimation techniques, such as Me, and is validated for four events for which both macroseismic and instrumental intensity data are available.
Frontotemporal dementia: past, present and future
Authors: Magrath-Guimet Nahuel
Published: October 2024

This scientific review comprehensively addresses frontotemporal dementia (FTD), providing a comprehensive overview of its historical evolution, clinical typology, underlying pathology, genetic basis and therapeutic approaches. The clinical diversity ofFTD and the importance of understanding its distinctive symptomatic manifestations are highlighted. The review explores the pathology, highlighting the accumulation of proteins such as tau and TDP-43, and explores the genetic implications, with emphasis on key mutations such as MAPT, progranulin and c9orf72. In addition to reviewing pharmacological therapies, non-pharmacological approaches are examined, including cognitive stimulation strategies and psychosocial support. The synthesis includes criticalanalyses of emerging therapies, from innovative pharmacological interventions to technological developments. This scientific summary provides an updated view of FTD, fostering a comprehensive understanding of this complex clinical entity and highlighting promising avenues for the development of more effective and personalized therapeutic interventions.
Explorations in Contemporary Analytic Metaphysics: Mind, Identity, and Society
Authors: Batista Ricardo Barroso , Nobre Bruno
Published: October 2024

Analytic Metaphysics represents a recent evolution of one of the oldest philosophical disciplines, now redefined by the methods of analytic philosophy. This contemporary approach reformulates the traditional ontological questions about existence, reality, and the nature of the Universe, prioritizing rigorous logical analysis and language. Analytic metaphysics, contrasted with continental ontology or traditional metaphysics, has surpassed the popularity of classical metaphysics, establishing itself as the predominant metaphysical stream in philosophical thought. In this special issue of the Revista Portuguesa de Filosofia (Portuguese Journal of Philosophy), we reflect on the current dynamics of analytic metaphysics, emphasizing its continuity with the metaphysical tradition or on new perspectives and pivotal issues driving analytic ontology.
Experience, Experiments, and the History of Empiricism
Authors: Allen Barry
Published: October 2024

This paper discusses arguments from my recent book, Empiricisms: Experience and Experiment from Antiquity to the Anthropocene (2021). I discuss the origin of empiricism in ancient Greek medicine, and its merger with experimental research in the modern period. I also discuss the arguments of recent critics of empiricism, including W. V. Quine, Donald Davidson, and Richard Rorty. I introduce a distinction between theorematic and problematic empiricism and show how this difference divides the various empiricisms of history. My conclusions are: 1. Knowledge requires experience; results have to be tested, which takes experience. 2. The “experience” of empirical philosophy is the experience from which we learn. 3. Experimental values are many, but truth is not one of them. 4. Empiricism began as an antidote to rationalism, and that remains its vocation today.
Southeastern Ohio Hemlock Stands Prior to Hemlock Woolly Adelgid Infestation: Baseline Conditions from 2 Surveys a Decade Apart
Authors: Knisely Jordan , Dyer James
Published: October 2024

The Hocking Hills of southeastern Ohio are situated at the western range boundary of eastern hemlock, where this foundation species occurs in isolated pockets in ravines and on steep slopes. The goal of this study is to characterize these hemlock stands prior to infestation by hemlock woolly adelgid (HWA), which recently entered the state and is likely to cause high mortality if untreated. Individuals in 30 plots established from 2008 to 2011 were resurveyed in 2020, allowing determination of growth rates and mortality rates. Each plot was paired with an upslope transect in the resurvey to record non-hemlock species likely to seed in from above. Tree species diversity in the plots is low (Shannon H’ < 1), as eastern hemlock remained the dominant species in all plots; storm damage and competitive thinning appeared to account for most mortality across all species. Hemlock growth rates were comparable to deciduous species. Common co-occurring species are statistically associated with particular topographic and soil properties on the plots. Following future hemlock mortality, tulip-poplar, chestnut oak, white oak, sweet birch, and red maple may be among the first species to dominate the canopy; Japanese stiltgrass currently appears to be the invasive species of greatest concern. An understanding of pre-HWA composition, structure, and forest dynamics can inform restoration efforts, if in the future long-term, sustainable HWA control or host-tree resistance is developed; this understanding can also apprise management and conservation efforts in the unique hemlock stands of southeast Ohio.
Biofilm-Induced Bone Degradation in Osteomyelitis
Authors: Al Ghaithi Ahmed , Husband John , Al Bimani Attika , Al Kindi Mohammed , Al Maskari Sultan
Published: October 2024

Objectives: Osteomyelitis, marked by bone inflammation due to microbial infection, presents significant healthcare challenges. While the protective role of biofilm in bacterial immunity and persistence is well-documented, its direct impact on bone degradation in osteomyelitis remains inadequately characterized. This study aims to comprehensively examine the direct effects of biofilm-forming pathogens on human bone, providing new insights into the mechanisms of bone destruction in osteomyelitis. Methods: Bone sections were collected from patients undergoing total knee replacement surgery between January 2021 and December 2022 for this study at Sultan Qaboos University Hospital. Then samples were inoculated with Staphylococcus aureus to simulate in-vitro bone infection. We then used Raman spectroscopy and Scanning Electron Microscopy (SEM) for detailed analysis of the bacterial interaction with bone tissue. Results: SEM images depicted trabecular destruction caused by biofilm. Biofilm-forming pathogens contribute directly to bone exhibited by SEM images with marked trabecular destruction. Raman analysis showed a significant increase in the carbonate-phosphate ratio in inoculated samples (619%) compared to controls (47%). Mineral content decreased in inoculated samples, and the carbonate-to-amide I ratio reduced by 47% in inoculated and 80% in controls. The inoculated samples exhibited an 82% shift in collagen crosslinking compared to 72% in controls. Conclusion: This research enhances our comprehension of the mechanisms behind bone destruction in osteomyelitis and underscores the intricate role of biofilm in the disease's development. These findings highlight the importance of biofilm in bone degradation and its potential implications for managing infections.
Vitamin D Status and Oxidative Stress in Children with Sickle Cell Anaemia in Sagamu, Nigeria
Authors: Sonuga Ayobola A , Sonuga Oyebola O , Olawale Olatunbosun O , Ogundeji Sunday P
Published: October 2024

Objectives: Sickle cell anaemia (SCA) is characterized by nutritional deficiencies and oxidative stress. Vitamin D possesses antioxidant properties but its role in SCA in sub-Saharan Africa has not been fully understood. The relationship between Vitamin D status, oxidative stress and antioxidants status in children with SCA was investigated for its possible role in reducing complications arising from oxidative stress in SCA. Methods: Case-control study involving 100 HbS genotype and 100 HbA genotype children (control) of comparable age (5-12 years). Baseline characteristics were obtained and serum vitamin D, calcium, CAT, SOD, GPX, GST and XO levels were quantified by standard laboratory methods. Results: Serum levels of vitamin D, calcium, CAT, SOD, GPX and GST were significantly lower in SCA group compared to the control, while the XO level was significantly higher in the HbS group compared with control. There was positive correlation between vitamin D, CAT and SOD (r = 0.821, 0.869), weak positive association between vitamin D and Ca (r = 0.545) and no significant relationship between vitamin D and other measurands in the SCA group. Conclusion: Sufficient vitamin D status might impact positively on the antioxidant status in SCA individuals thereby reducing associated complications.
Assessing Vascular Biomarkers and Their Association with Hypertension in Paediatric Chronic Kidney Disease
Authors: Sayed Samira Z , Mohamed Engy R , Moustafa Mohamed TA , Ali Lamia H , Mahgoob Mohamed H
Published: October 2024

Objectives: This study aims to examine the correlation between children with chronic kidney disease (CKD) and endothelial dysfunction biomarkers, including asymmetric dimethylarginine (ADMA), angiopoietin-2 (Ang-2), and vascular endothelial growth factor-A (VEGF-A), as well as blood pressure and cardiovascular risk. Methods: A cross-sectional study included 90 children divided into two groups: 45 with CKD with different stages and 45 healthy controls. Blood pressure was taken, and levels of ADMA, Ang-2, and VEGF-A were determined. November 2021 to October 2022 was the time frame of the study. Results: The results showed that children with CKD had significantly higher levels of ADMA, Ang-2, and VEFG-A compared to the control group. Systolic and diastolic blood pressure showed a positive connection with the elevated biomarkers but estimated glomerular filtration rate (eGFR) showed a negative association. Conclusion: Increased cardiovascular risk and antihypertensive have been associated with elevated levels of VEFG-A, Angiopoietin-2, and ADMA in children with chronic kidney disease. These biomarkers might be useful in clinical evaluations to improve therapy and results for children with CKD.
Empagliflozin use in cardiac transplant patients
Authors: Butt Muhammad I , Albalwi Roaa MH , Alnassar Norah , Alghambi Reem
Published: October 2024

Objectives: Sodium-glucose transport protein 2 inhibitor |(SGLT2) drugs are used to treat patients with type 2 diabetes. In additions to their beneficial metabolic effects in lowering the glaciated hemoglobin, body weight and blood pressure, these agents have shown favorable and protective effects on the heart and the kidneys. These cardio renal benefits are seen even in people without diabetes. There is little evidence on the safety and efficacy of SGLT2 inhibitors use in cardiac transplant recipients. We wanted to study the cardiac transplant recipients who used Empagliflozin for the treatment of diabetes to evaluate its safety and efficacy in this niche sub group of patients. Method: We retrospectively identified 20 patients on the cardiac transplant recipient register taking Empagliflozin (Jardiance) or Empagliflozin combined with Metformin (Synjardy). We studied the safety and efficacy parameters. Results: Our results show improvement in HBA1c, body weight and stability in serum creatinine. There was no increased risk of genitourinary infection, hypoglycemia or diabetic ketoacidosis. Conclusion: While we need larger studies in cardiac transplant patients taking Empagliflozin, our small study provides assurance that Empagliflozin is safe to use in cardiac transplant recipients.
Diaphragmatic Paralysis Following Chest Tube Insertion in an Infant
Authors: Al Ghafri Mohammed , Al Hanshi Said , Elkhamisy Ahmad E , Fouad Ahmed M
Published: October 2024

Diaphragmatic paralysis (DP) can occur due to central nervous system pathology or peripheral nerve injury. Direct injury to the phrenic nerve after intercostal chest drain (ICD) insertion for treatment of pneumothorax is an infrequent complication. We present a 4-month-old baby, ex-preterm 27 weeks, who was admitted to a tertiary care hospital pediatric intensive care unit in Muscat, Oman, in 2023 with severe respiratory syncytial virus bronchiolitis and required intubation and mechanical ventilation (MV). His illness was complicated by right-side pneumothorax that required ICD insertion. Post-extubation, he had persistent tachypnea with the inability to be weaned from noninvasive ventilation (NIV). Chest x-ray (CXR) and fluoroscopy showed a high right diaphragm dome with paradoxical movements. He improved dramatically after the plication of the right diaphragm and was discharged home on the 9th day after the plication.
Diagnostic Accuracy of Abdominal Ultrasonographic Sliding Sign in the Evaluation of Severe Intra-Abdominal Adhesions involving the Uterus in Women Undergoing Repeat Cesarean Delivery
Authors: Taha Amira M , Moawad Wesam A , Saed Sara AA , Alhejazi Tala J , Sabri Youstina A , Abd-ElGawad Mohamed , Alcazar Juan L , Al Riyami Nihal , Khafagy Ayatallah , Mohammed Yasmine A , Saad Ahmed H
Published: October 2024

We aimed to assess diagnostic accuracy of transabdominal ultrasonography(TAS) sliding sign in diagnosing severe intra-abdominal adhesions with repeated Cesarian Delivery(CD). We comprehensively searched PubMed, Google Scholar, Web of Science, and Scopus for published studies till October 2022 that evaluated the sliding sign as a predictor of intra-abdominal adhesions after repeat CD. We used STATA and Comprehensive Meta-Analysis for meta-analysis. Seven studies(1318 patients) were eligible for inclusion. For identifying severe intra-abdominal adhesions, sliding sign on TAS had a combined sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio of 64%(95% CI, 55-71%), 93%(95% CI, 89-96%), 9.5(95% CI, 5.7-16), 0.39(95% CI, 0.31-0.49), and 24(95% CI, 13-46), respectively. Prediction intervals for sensitivity and specificity were 0.444 to 0.786 and 0.711 to 0.985, respectively. We concluded that sliding sign on TAS is a simple, non-invasive, good negative and practical method to exclude severe intra-abdominal adhesions involving the uterus with low sensitivity and high specificity.
Acute Self-Harm Ideation as Presenting Adverse Event Associated with Adalimumab Treatment of Severe Scalp Psoriasis
Authors: Cortes Julian , Oldenburg Reid
Published: October 2024

We present a case of a 34-year-old woman with severe scalp psoriasis who developed acute self-harm ideations and major depressive symptoms shortly after initiating adalimumab treatment. The patient had a history of major depressive disorder, post-traumatic stress disorder, and anxiety, all well-controlled with multiple medications. Following the administration of adalimumab, she experienced intrusive thoughts of self-harm and exacerbation of depressive symptoms, prompting immediate discontinuation of the drug. The patient's symptoms resolved completely three weeks after discontinuation. This case highlights the potential psychiatric risks associated with adalimumab therapy for psoriasis, especially in patients with preexisting mental health conditions. Dermatologists should carefully evaluate patients for psychiatric disorders and suicide risk factors before initiating treatment and be vigilant in monitoring for adverse psychiatric events during therapy. Proper counseling and prompt identification of adverse events are crucial to prevent serious outcomes.
Endobronchial Metastasis with Extension to the Left Atrium from Adenocarcinoma of Gastric 3 Years after Total Gastrectomy
Authors: Shakerian Behnam , Mandegar Mohammad H
Published: October 2024

Endobronchial metastases with extension to the heart from gastric cancer are very rare. This is a case report of a 69-year-old man who presented to a tertiary care hospital in Shahrekord, Iran, in 2020 with a history of cough and bloody sputum. He has a history of gastric carcinoma and underwent total gastrectomy and adjuvant chemotherapy 3 years ago. Following imaging and pathology studies, the patient was diagnosed with endobronchial metastases and extension to the left atrium. Chemoradiation regimen yielded a good response, preserving quality of life.
Синтез наноматериалов в пламени
Authors: Лесбаев Б.Т. , Приходько Н.Г. , Азизов З.М. , Мансуров Б.А. , Атаманов М.К.
Published: October 2024

В статье представлены результаты экспериментальных исследований по синтезу фуллеренов, наночастиц оксида никеля и графенов в пламени, которые были проведены в Институте проблем горения. Приведены условия синтеза фуллеренов С60 в предварительно-перемешанном бензол-кислородном пламени при наложении электрического поля и давлении 40 торр. Максимальный выход фуллеренов С60 до 15% обнаружен при наложении на пламя тлеющего разряда с использованием межэлектродной системы кольцо-плоскость. Выявлены условия синтеза наночастиц оксидов никеля в диффузионном пропан-кислородном противопоточном пламени и установлено, что, варьируя временем обработки нихромовой проволоки от 5 с до 2 мин, можно регулировать размеры образующихся наночастиц оксидов никеля от 70 до 700 нм, при этом последующая обработка пламенем более 2 мин не приводит к ощутимым изменениям размеров. Определены условия синтеза графенов в коаксиальном пламени и установлено, что при организации коаксиального горения, изменяя виды топлив, можно добиться условий для получения графенов с заданным числом слоев.
Твердые сорбенты для улавливания диоксида углерода после сжигания топлива. Краткий обзор
Authors: Ергазиева Г. , Досумов К. , Макаева Н. , Анисова М. , Мамбетова М. , Худайбергенов Н. , Серкебаев Б. , Кабылбек А. , Акказин Е.
Published: October 2024

Улавливание диоксида углерода является важным и эффективным подходом к контролю выбросов CO2 в атмосферу из точечных источников, таких как электростанции, работающие на ископаемом топливе, промышленные печи, цементные заводы и др. В настоящее время наиболее развитой технологией улавливания CO2 является очистка жидким амином. В качестве альтернативы можно использовать твердые сорбенты для эффективного улавливания CO2, устраняя при этом недостатки, связанные с жидкими аминовыми сорбентами. В этом обзоре рассматриваются некоторые твердые сорбенты CO2, такие как цеолиты, оксиды щелочных и щелочноземельных металлов, для улавливания CO2 при умеренных и высоких температурах. Обсуждаются современное состояние, проблемы, возможности и будущие направления исследований этих сорбентов.
Опытно-промышленные испытания универсального огнеупорного бетона на металлургических предприятиях Республики Казахстан
Authors: Сатбаев Б.Н. , Жарменов А.А. , Шалабаев Н.Т. , Исагулова Д.А. , Терликбаева А.Ж. , Сатбаев А.Б. , Сатбаев С.Б. , Арсентьев В.А. , Ефремова С.В.
Published: October 2024

Изучено поведение огнеупорного бетона как универсального высокотемпературного футеровочного материала для объектов доменного и анодного производств. Представлены результаты опытно-промышленных испытаний универсального бетона в АО «Арселор-Миттал Темиртау», на Жезказганском медеплавильном заводе ТОО «Казахмыс Смэлтинг», в Усть-Каменогорском металлургическом комплексе ТОО «Казцинк». Установлено, что новый универсальный огнеупорный бетон характеризуется высокими эксплуатационными показателями. Его применение обеспечивает увеличение жизненного цикла металлургических агрегатов при сокращении удельного расхода огнеупоров на единицу выпускаемой металлопродукции.
ASSESSING UNDERSTANDING OF THE CONCEPT OF FUNCTION, ITS DIFFERENT REPRESENTATIONS AND THE LINKS BETWEEN THEM
Authors: Schnurerova Eniko , Lukac Stanislav
Published: October 2024

In these times of change and constant development, it is important that pedagogical approaches reflect modern trends and the needs of students. In mathematics, the notion of function is one of the key concepts. Despite the fact that the concept of function starts to be built in primary school, even in secondary school many students show gaps in their understanding of the concept of function, its different representations and the links between them. Our research focuses on the application of inquiry-based teaching (IBT) in the learning of the concept and properties of functions. This paper describes the initial stage of research based on a design-based research strategy oriented towards the design and development of methodological materials for teaching functions. The second part of the paper consists of the evaluation of a test designed to assess the development of functional thinking of primary school students.
АДМІНІСТРАТИВНО-ПРАВОВЕ РЕГУЛЮВАННЯ ЗАХОДІВ ПРОТИДІЇ КІБЕРЗАГРОЗАМ АКТАМИ ЄВРОПЕЙСЬКОГО РІВНЯ
Authors: Криволап Євгеній
Published: October 2024

Метою статті є дослідження системи та змісту актів європейського рівня у сфері протидії кіберзагрозам. Методи дослідження: документальний аналіз, узагальнення правової інформації, інформації із сфери кіберзахисту інформаційно-комунікаційних систем. Результати: визначені особливості правового регулювання заходів забезпечення кібербезпеки правовими актами європейського рівня. Наголошено, що три засадничих нормативних акти ЄС у сфері кіберзахисту, а саме: Директива Європейського парламенту і Ради ЄС 2016/1148 від 06.07.2016 про заходи для високого спільного рівня безпеки мережевих та інформаційних систем на території Союзу; Директива Ради 2008/114/ЄС від 08.12.2008 року про ідентифікацію і визначення європейських критичних інфраструктур та оцінювання необхідності покращення їх охорони та захисту; Регламент Європейського парламенту і Ради (ЄС) 2016/679 від 27.04.2016 року про захист фізичних осіб у зв’язку з опрацюванням персональних даних і про вільний рух таких даних, – підлягають імплементації у законодавство України відповідно до Угоди про асоціацію між Україною та Європейським Союзом 2014 року. Вперше встановлено, що керівними документами європейського рівня щодо практичного впровадження вимог вказаних Конвенцій про кіберзахист слід вважати і брати до виконання Конвенцію від 23.11.2001 року Ради Європи «Про кіберзлочинність» з Додатковим протоколом від 28.01.2003 року до Конвенції про кіберзлочинність; Рекомендацію від 30.10.1997 р. № R (97) 19 Комітету міністрів Ради Європи «Про показ насильства електронними ЗМІ»; Рекомендацію від 30.10.1997 р. № R (97) 20 Комітету міністрів Ради Європи «Про розпалювання ненависті»; Рекомендацію від 27.04.1989 р. № R (89) 7 Комітету міністрів РЄ «Про принципи поширення відеозаписів насильницького, жорстокого чи порнографічного змісту». Здійснюються заходи унормування вимог до програмного та апаратного забезпечення, спрямованих на протидію кібервтручанням. Обговорення: реалізація зазначених положень дозволяє виробити національні стандарти належного захисту від кібервтручань та глядачів від «необґрунтованого показу насильства».
ОСОБЛИВОСТІ ФУНКЦІОНУВАННЯ ФІНАНСОВОЇ СИСТЕМИ УКРАЇНИ ТА УПРАВЛІННЯ АКТИВАМИ В УМОВАХ ВІЙСЬКОВОЇ АГРЕСІЇ
Authors: Устинова Ірина , Білявська Валерія
Published: October 2024

Мета: полягає в огляді та аналізі правової природи фінансової системи України, основних аспектів та виявлення недоліків, що гальмують процес розвитку фінансової системи, пошук можливих шляхів удосконалення, аналіз проблем та визначення перспектив функціонування фінансової системи в сучасних умовах, а саме в умовах дії воєнного стану. Методи дослідження: в статті використані наступні загальнонаукові методи дослідження спостереження та опис та теоретичні: аналіз, узагальнення, пояснення, а також системний, функціональний, конкретно-соціологічний. Результати: особливу увагу приділено формуванню бюджетів, які відчули найбільший тиск, і спрямуванню фінансових ресурсів на оборонні та соціальні потреби. Додатково розглядаються проблеми незбалансованості видатків та доходів бюджету, а також валютного ринку, який продовжує функціонувати з обмеженнями, встановленими під час воєнного стану. У статті також розглядаються існуючі та потенційні шляхи вирішення проблем функціонування фінансової системи, зокрема їх адаптація до потреб оборони та забезпечення безперебійного функціонування системи державних фінансів. Обговорення: військове вторгнення на територію України та глобалістичні процеси в світі призвели до суттєвих негативних змін в існуванні фінансової системи України, і тому потребують ново практики вирішення питань формування бюджету країни, місцевих бюджетів, суттєвих корекцій у податковому законодавстві та зміні розміру податкового тягаря. Суттєвою складовою вирішення цих питань, є розширення співпраці з Міжнародними фінансовими організаціями, сприяння покращенню інвестиційного клімату тощо.
ДО ПИТАННЯ ПРО НАДАННЯ ВОЛОНТЕРСЬКОЇ ДОПОМОГИ ВРАЗЛИВИМ ГРУПАМ НАСЕЛЕННЯ В СИСТЕМІ СОЦІАЛЬНОЇ ПІДТРИМКИ
Authors: Кашицький Андрій
Published: October 2024

Мета: визначити місце волонтерської допомоги вразливим групам населення в системі соціальної підтримки. Методи дослідження: використані формально-логічний, догматичний, порівняльний, системно-структурний методи. Результати: зроблено висновок, що важливу роль у системі соціальної підтримки населення відіграє волонтерська діяльність, що полягає у добровільному взятті обов’язків надавача соціальних послуг особам/сім’ям, які перебувають у складних життєвих обставинах. Обговорення: напружена соціально-економічна ситуація, погіршення якості життя населення, виникнення нових груп ризику в умовах війни – все це зумовлює розширення соціальної підтримки населення, в тому числі за рахунок посилення волонтерської діяльності, покликаної доповнювати послуги, що надаються державою.
ПОНЯТТЯ ТА ОЗНАКИ ОРГАНІЗАЦІЇ ПРАЦІ І ТРУДОВИХ ВІДНОСИН
Authors: Стадніченко Сергій
Published: October 2024

Мета: вивчення основних аспектів організації праці та трудових відносин як ключових елементів сучасного управління підприємствами в умовах ринкової економіки. Дослідження спрямоване на виявлення основних характеристик та елементів цих понять, а також аналіз їх впливу на ефективність і стійкість підприємств. Основна увага приділяється розкриттю правових, соціальних та економічних аспектів трудових відносин, а також проблемам, які виникають при впровадженні нових моделей організації праці в різних соціально-економічних умовах. Методи дослідження: використано міждисциплінарний підхід, який поєднує економічний, правовий та соціальний аналіз. Використовуються методи порівняльного аналізу для дослідження різних моделей організації праці, прийнятих у різних країнах, та їх адаптації до місцевих умов. Також застосовуються методи системного аналізу для вивчення взаємозв’язку між організацією праці та трудовими відносинами. Використані джерела включають наукові публікації, правові документи та аналітичні огляди, що дозволяє комплексно підійти до досліджуваної тематики. Результати: дослідження показало, що ефективна організація праці включає комплекс заходів, спрямованих на раціональне використання робочої сили та засобів виробництва, таких як розподіл праці, нормування, стимулювання, організація робочих місць тощо. Вона сприяє оптимізації трудової діяльності, підвищенню продуктивності та досягненню стратегічних цілей підприємства. Також виявлено, що трудові відносини, як специфічний вид правових відносин, є важливим фактором у забезпеченні стабільності та справедливості трудового процесу. Аналіз правових, соціальних та економічних аспектів трудових відносин підкреслює їхню роль у підтримці ефективності управління трудовими ресурсами. Обговорення: обговорюються основні виклики, з якими стикаються керівники при впровадженні нових моделей організації праці, особливо при адаптації зарубіжних методів до місцевих соціально-економічних умов. Визначено, що важливим є врахування національних особливостей та законодавчих вимог під час адаптації методик, оскільки неврахування цих факторів може призвести до неефективності управлінських рішень. Автори доходять висновку про необхідність комплексного підходу до управління працею, який включає як ефективну організацію трудових процесів, так і належне регулювання трудових відносин для досягнення високих показників продуктивності, задоволеності працівників і стійкого розвитку підприємств у глобалізованому світі.