bluuebunny/crossref_metadata_2025 huggingface dataset:
Educação ambiental em cursos de administração do estado do Rio Grande do Norte
Authors:   , Enéas Ana Paula de Sousa
Published: January 2025

A questão ambiental nas organizações modernas ocupa hoje grande parcela dos esforços dos administradores, exigindo um novo perfil do profissional que consiga articular e organizar uma estrutura organizacional que relacione todos os setores das organizações rumo à responsabilidade social e ambiental. Portanto, formar administradores comprometidos com a questão ambiental e atuantes nas organizações constitui-se como um desafio para as Instituições de Ensino Superior (IES), sendo fundamental que os alunos dos cursos de Administração tenham em seus currículos disciplinas voltadas para a questão ambiental, visto que tais questões são de extrema importância nos círculos acadêmicos. Por isso, o objetivo desse trabalho foi o de analisar como a temática ambiental é trabalhada em cursos de Administração em Instituições de Ensino Superior do Estado do Rio Grande do Norte, visto que a educação ambiental, através de seus aportes teóricos, abre um estimulante espaço para um repensar de práticas sociais e do papel dos educadores. Para isso, foi realizado um estudo multi-casos, de caráter descritivo, e como procedimentos de coletas de dados foram realizados a pesquisa documental, através da análise dos PPCs dos cursos e a entrevista com os coordenadores dos cursos e com professores. Foram pesquisados 22 cursos de administração do estado do RN, sendo o total de 22 coordenadores entrevistados, e cada coordenador indicava um professor do curso de administração para participar da entrevista, tendo um número de 22 professores. Além das entrevistas, foram analisados os PPCs dos cursos, no entanto foram disponibilizados apenas 9 documentos. Os resultados da pesquisa apontam que, apesar da existência de iniciativas que abordam as questões ambientais nos cursos pesquisados, percebe-se que elas ocorrem de forma isolada e limitada a professores que têm maior aproximação ou envolvimento com a temática, não sendo realizada de modo interdisciplinar e transversal em todas as disciplinas e atividades dos cursos, como preconiza a legislação de educação ambiental. Para isso, recomenda-se que haja uma construção coletiva em torno do tema pelos cursos de administração com as suas devidas IES e todos os envolvidos, sendo eles colaboradores, professores e discentes, para que não se tenha o risco de descontinuidade das ações.
Computational Approaches for Multitarget Drug Design in Alzheimer's Disease: A Comprehensive Review
Authors: Guerguer Fatima Zahra , Khedraoui Meriem , Samadi Abdelouahid , Chtita Samir
Published: January 2025

Alzheimer's disease (AD) is a chronic and progressive neurodegenerative brain
disorder, primarily affecting the elderly. Its socio-economic impact and mortality rate are
alarming, necessitating innovative approaches to drug discovery. Unlike single-target diseases,
Alzheimer's multifactorial nature makes single-target approaches less effective. To
address this challenge, researchers are turning to drug design strategies targeting multiple
disease pathways simultaneously. This approach has led to the promising identification of
dual or multiple-target inhibitors, offering new perspectives for improving disease management.
Computer-Aided Drug Design (CADD) such as virtual screening, docking,
QSAR, molecular dynamics, ADMET prediction, etc., are valuable tools for designing
and identifying new multi target directed ligands (MTDLs). These methods enable efficient
screening of extensive compound libraries and accurate prediction of pharmacokinetic
profiles, optimizing development costs and time. Challenges such as model accuracy,
simulation complexity, and data integration persist. Addressing these issues requires
advances in in silico modeling, high-performance computing, and experimental validation.
In this regard, this review highlights recent advances using various computational methods
to screen and identify new candidate compounds containing different heterocyclic
motifs that could serve as potential bases for designing ligands targeting multiple targets
for Alzheimer's disease.
Resveratrol Anti-inflammatory Effect against Palmitate-induced Cytotoxicity in Raw 264.7 Macrophages
Authors: Elmorsy Ekramy M. , Al-Ghafari Ayat B. , Al Doghaither Huda A.
Published: January 2025

Background:

Resveratrol (RES) is a phytochemical bioactive compound with
suggested therapeutic benefits.

Objective:

The current work aimed to evaluate the anti-inflammatory effect of RES
against palmitate (PA) induced lipotoxicity in raw 264.7 macrophages cell line.

Methods:

The cells viability was assessed by lactate dehydrogenase assay. Then the effects
of RES and PA on nitric oxide (NO), triglyceride (TG) content, and cytokines release
were studied. The effect of RES and PA on the treated cells bioenergetics and redox
status was evaluated via different assays

Results:

The results showed that at doses of 10 and 20μM, RES dramatically increased
the vitality of PA-exposed macrophages with dramatic significant decrease in the release
the proinflammatory cytokines TNF-α, MHGB-1, IL-1β, and IL-6 and their coding
genes expression with marked improvement in the cells phagocytic capacity. In addition,
RES dramatically lowered the levels of NO and TG in PA-stimulated
macrophages. In addition, PA markedly decreased mitochondrial complexes I and III activities
with decreased mitochondrial membrane potential and lowered ATP production
with induction of oxidative stress. RES was shown to mitigate the effect of PA on
macrophages bioenergetics and the oxidative damage and counteracted PA effect on
genes linked to oxidative damage, such as Nrf2, Ho-1, NF-κB p65, SOD1, and SOD2.

Conclusion:

RES could reduce PA-induced lipotoxicity in macrophages via enhancing
their viability and counteracting the excess release of cytokines through alleviating PAinduced
bioenergetic disruption and oxidative damage with a suggested positive impact
of RES on obesity related illnesses caused by triggered cellular inflammation.
Sustainable Synthesis of Medicinally Important Heterocycles
Authors: Joardar Dripta De , Sarkar Rajarshi , Maiti Dilip K.
Published: January 2025

Sustainable chemistry and nature-friendly protocols are not only luxury but has become
essential requirement for the modern society as it progresses towards a more responsible future. To
match the current needs of the community, industries and in particular chemical industry is looking for
novel and cheap strategies that have less adverse effects on the environment. Heterocyclic compounds
are one particular motif, which is prevalent in nature. It is found in a wide range of synthetic and natural
compounds, both established and in development as potent therapeutic candidates. According to the
US retail market in 2014-2015, heterocyclic moieties constitute the basic skeletons for 80% of marketed
pharmaceuticals. However, majority of the synthetic methodologies still uses classical approaches
with toxic solvents, stoichiometric reagents, reactions with less atom economy etc. Thus, there is an
urgent need for green, sustainable alternatives of the classical reactions. In recent years, an array of
diverse approaches and technologies have been discovered by the scientific community to address the
issue of eco-friendly manufacture of various pharmaceutically and medicinally important heterocyclic
molecules. In this context, the current review will summarize various reported green pathways to the
heterocyclic architecture, particularly O, N, and S-heterocyclic compounds. The methods highlighted
in this article includes reaction in environment friendly nonconventional media, solvent-free approaches,
heterogeneous catalysis, organocatalysis, electrochemical reactions, microwave-mediated reactions,
ultrasound-based reactions, enzymatic reactions, biocatalysis, and others.
LncRNA-DANCR: A Key Player in Colorectal Cancer Development and Progression
Authors: Anbiyaee Omid , Ghaedrahmati Farhoodeh , Azizidoost Shirin , Radmehr Safa , Farzaneh Maryam , Salehi Abdolah Mousavi
Published: January 2025

Colorectal Cancer (CRC) is a significant global health issue, being the third
most common cancer worldwide and the second most frequent cause of cancerrelated
deaths. It occurs when cells in the colon or rectum grow uncontrollably, often
developing from precancerous polyps. Genetic predisposition and environmental
factors, such as diet and lifestyle, contribute to the disease. Recent research has
focused on molecular targeted therapies and non-coding RNAs, particularly long noncoding
RNAs (lncRNAs), which play a critical role in regulating CRC development and
progression. DANCR interacts with microRNAs, proteins, and mRNAs, influencing
gene expression and stability. DANCR functions as a promoter of tumor growth,
invasion, metastasis, proliferation, migration, apoptosis, disease progression, and
prognosis in various cancers. In CRC, DANCR influences both progression and
clinical outcomes. This review aims to comprehensively explore the current knowledge
regarding DANCR in CRC, including its molecular characteristics, expression patterns,
and involvement in regulatory mechanisms, as well as its potential use as a
diagnostic, prognostic, and therapeutic tool.
Soluplus Stabilized Amorphous Dispersions for Enhanced Oral Absorption of Felodipine
Authors: Zhang Shujuan , Xiong Subing , Gong Ying , Wang Liangliang , Huang Dayun
Published: January 2025

Background:

Overcoming the poor aqueous solubility of small-molecule drugs is a major
challenge in developing clinical pharmaceuticals. Felodipine (FLDP), an L-type calcium calcium
channel blocker, is a poorly water-soluble drug.

Objectives:

The study aimed to explore the potential applications of polyvinyl caprolactam-polyvinyl
acetate-polyethylene glycol (Soluplus) stabilized amorphous dispersions for augmenting the oral delivery
of poorly water-soluble drugs.

Methods:

Soluplus-stabilized amorphous FLDP (FLDP-SSAs) was prepared using a two-phase mixing
method. The samples were analyzed for their microscopic and macroscopic behavior using polarized
light microscopy (PLM), differential scanning calorimetry (DSC), molecular simulation, and in
vitro dissolution studies. Subsequently, the pharmacokinetics of FLDP-SSAs were evaluated.

Results:

The maximum drug-to-Soluplus mass ratio of FLDP-SSAs was 50:50, with a drug concentration
of 8.0 mg/mL. They exhibited an amorphous nature, as confirmed by PLM and DSC. FLDPSSAs
generated nanoparticles with a particle size of approximately 50 nm during in vitro dissolution.
Compared to FLDP oral solution, FLDP-SSAs exhibited higher solubility due to their amorphous
nature and the generation of nanoparticles. The area under the curve (AUC) for oral FLDP-SSAs was
16.7-fold larger than that of the FLDP suspension.

Conclusion:

FLDP-SSAs could stabilize FLDP in an amorphous state and serve as drug carriers to
enhance oral absorption.
Advances in Understanding How RhoB Regulates Akt Inhibition Efficacy in NSCLC
Authors: Akgun Nurullah , Halici Zekai , Cadirci Elif
Published: January 2025

Objectives:

Increasing the effectiveness and reliability of Akt inhibition in lung cancer treatment may pave the way for a more favorable use of this method in the future. Therefore, we aimed to evaluate the possible role of RhoB in the regulation of Akt inhibition in NSCLC.

Material and Methods:

The study was conducted using the NSCLC cell line A549. Small interfering RNA (siRNA)-mediated RhoB knockdown was performed and combined with perifosine (Akt inhibitor) treatment. Cell proliferation was detected by xCELLigence® RTCA. RhoB, pAkt, and Bcl2l11 expressions were analyzed by ELISA. Apoptosis rates were determined by flow cytometry.

Results:

We knocked down RhoB in A549 cells using siRNA. According to the results of the 72-hour experiment, RhoB upregulation was observed to reduce the antiproliferative ac-tivity of the Akt inhibitor. The pAkt level was significantly lower in the group where the Akt inhibitor was applied to RhoB-silenced cells via siRNA compared to other treatment groups. The percentage of apoptosis in the group where the Akt inhibitor was applied to RhoB-silenced cells was found to be significantly higher than in the RhoB-suppressed group.

Conclusion:

Both proliferation and apoptosis tests determined that the RhoB molecule is a negative regulator of the anti-tumor activity of Akt inhibition in non-small cell lung cancer. This study suggests that RhoB expression may play a critical role in the regulation of Akt inhibition in NSCLC, potentially opening new avenues for treatment strategies
Partial Dopamine D2/3 Agonists and Dual Disorders: A Retrospective-Cohort Study in a Real-World Clinical Setting on Patients with Schizophrenia Spectrum Disorders and Cannabis Use Disorder
Authors: Trovini Giada , Lombardozzi Ginevra , Kotzalidis Georgios D. , Pagano Ilaria , Amici Emanuela , Giovanetti Valeria , Perrini Filippo , Fagiolini Andrea , De Filippis Sergio
Published: January 2025

Introduction/Objective:

Schizophrenia with substance use disorder is a complex clinical
condition that may increase treatment resistance. Cannabis use disorder is frequently associated with
psychosis and the causal link has still to be defined. Partial D2/3 agonists may ensure limbic dopamine
release normalization while avoiding reduced frontocortical dopamine release, which would
contribute to negative symptoms. We aimed to observe the clinical course of patients with schizophrenia
comorbid with cannabis use disorder while being treated with oral or long-acting injectable
D2/3 partial agonists.

Methods:

We observed 96 young adults with schizophrenia/schizoaffective disorder comorbid with
cannabis use disorder during 18 months of treatment with aripiprazole long-acting injectable or oral
aripiprazole or brexpiprazole. The assessment comprised Clinical Global Impressions-Severity, Positive
and Negative Syndrome Scale, Brief Psychiatric Rating Scale, Barratt Impulsiveness Scale, and
Visual Analog Scale for Craving.

Results:

Included were 17 women and 79 men (mean age = 26.89 ± 4.74 years). The sample responded
favorably to treatment as assessed by all clinical scales, save for the impulsiveness scale
which showed no significant change. The four treatment samples responded well without differences,
but employing a general linear model, long-acting injectable aripiprazole and brexpiprazole
were better and similar on all clinical and craving scales compared to oral aripiprazole and to other
antipsychotics. Long-acting injectable aripiprazole fared better than brexpiprazole on general psychopathology,
negative symptoms, and craving, while the reverse was true for global severity. However,
the sample size imbalance did not allow for drawing strong conclusions. We found no significant
treatment resistance in our 96-patient sample.

Conclusion:

Partial D2/3 agonists may treat comorbid schizophrenia/schizoaffective disorder and
cannabis use disorder, improving the symptoms of both disorders and substance craving.
Comparison of Structural Stability of Monomeric and Dimeric Forms of Bovine Seminal Ribonuclease Using Molecular Dynamics Simulation
Authors: Soltani Leila Simaei , Gharouni Marzieh , Ghovvati Shahrokh , Javadmanesh Ali , Nasiri Mohammad Reza
Published: January 2025

Background:

Bovine Seminal Ribonuclease (BS-RNase) is a unique member of the
RNase A family found in the bovine seminal fluid. It is recognized for its antiviral and antitumor
properties, which make it a potential therapeutic agent.

Objective:

This study aimed to compare the stability of monomeric and dimeric forms of BS-RNase
using in silico methods.

Method:

The tertiary structures of BS-RNase as monomers and dimers were obtained from the Protein
Data Bank, and missing amino acids were modeled using the Modeller server. The predicted
structures were validated using SAVES 6 and ProSA web tools. Molecular dynamics simulations
were performed using GROMACS, and the resulting RMSD, RMSF, and Rg plots were analyzed.

Results:

The results indicated that the monomer's ERRAT score, Ramachandran plot, and Z-score
were better than the dimer's. RMSD, RMSF, and Rg plots were favorable for both structures, with
the monomer showing better stability than the dimer.

Conclusion:

Consequently, the monomeric form of BS-RNase is more stable than its dimeric form,
and the monomer can be more reliably used in pharmaceutical studies.
Predicting the Potential Mechanism of Radix Sophorae Flavescentis Treating Hepatocellular Carcinoma Based on the Strategies of Network
Pharmacology, Molecular Docking, and Molecular Dynamics Simulation
Authors: Hong Jing , Ding Jie , Wang Peng , Zhai Xiao-Feng , Pan Bo
Published: January 2025

Background and Objective:

Hepatocellular carcinoma (HCC) is a common hepatic malignant
tumor severely affecting the life and health of people globally. Radix Sophorae Flavescentis (RSF)
is a Chinese herbal medicine widely utilized in China. However, its main ingredients and mechanism
have not been fully illustrated. The current study explored the potential mechanism of RSF treating
HCC through network pharmacology, molecular docking, and molecular dynamics simulation.

Materials and Methods:

The potential RSF active compounds and the corresponding targets were
retrieved from TCMSP, TCMID, HERB, ETCM, and BATMAN-TCM databases. HCC-related target
genes were primarily mined using GeneCards and OMIM databases. The intersection target
genes of RSF and HCC were collected, and the protein-protein interaction (PPI) network was constructed
to obtain the core target genes of RSF in HCC. Gene Ontology (GO) and Kyoto Encyclopedia
of Genes and Genomes (KEGG) analyses were performed on the core targets. The network analysis
results were verified through molecular docking and molecular dynamics simulation using active
compounds and core targets.

Results:

In this study, 23 potentially active ingredients of RSF and 203 corresponding targets of the
active ingredients were mined, and 4594 HCC-related target genes were finally identified. Thereinto,
quercetin, luteolin, formononetin, and 8-isopentenyl-kaempferol were predicted to be the core targets,
and 61 core targets such as TP53, JUN, HSP90AA1, AKT1, MAPK1, RELA, TNF, and ESR1
were further screened through PPI network analysis. GO enrichment and KEGG pathway analysis
revealed that the treatment of HCC with RSF mainly involved the receptor signaling pathway of
vascular endothelial growth factor, cytoplasm, protein domain specific binding, and other biological
processes. Signaling pathways included pathways in cancer, Hepatitis B, IL-17 signaling pathway,
etc. Molecular docking and molecular dynamics simulations validated the above results.

Conclusion:

This study elucidated the potential mechanism of RSF in the HCC treatment through
network pharmacology, molecular docking, and molecular dynamics simulation, thereby offering
valuable insights for future clinical investigations.
Comparison of the Effects of Aromatherapy and Mindfulness through Social Media on the Sleep Quality of Women in the Postpartum Period - A Randomized Clinical Trial Study
Authors: Ghalgar Zahra , Vakilian Katayon , Rizi Soheila Mohamadi , Ghaemmaghami Mehrnoush , Moradzadeh Rahmatollah
Published: January 2025

Aim:

The present study aimed to compare the effect of two methods on mothers' sleep in
the postpartum period.

Background:

The postpartum period refers to the first 6 weeks after birth. Some mothers may find
it difficult to adapt to the new role, and thus the quality of their life and sleep may be affected.

Objective:

The objective of the present study was to compare the effect of aromatherapy and mindfulness
through social media during the postpartum period on sleep.

Methods:

This study was a randomized clinical trial study conducted in parallel design involving 3
groups (mindfulness, aromatherapy, and control) with an allocation ratio of 1:1:1. The population consisted
of women who had given birth one week before and were in the postpartum period. In the mindfulness
group (n=44), counseling was performed via WhatsApp in 8 sessions. The other group was
given the lavender essential oil (n=44); the members of this group joined the WhatsApp channel and
were shown how to use the essential oil (two drops on a napkin every other night before bed for 2
months). The control group (n=44) received routine postpartum care via WhatsApp. The quality of
sleep was assessed at the beginning of the study and 8 weeks after starting the intervention.

Result:

After the intervention, sleep quality was examined at 10.39 ± 3.46, 10.77 ± 3.72, and 8.82 ±
3.47 in the control, mindfulness, and aromatherapy groups, respectively (p=0.027). A difference
was found between the mindfulness group and the aromatherapy group after 8 weeks (p=0.03).

Conclusion:

The results of the present study have indicated the important role of complementary
medicine as aromatherapy in improving sleep quality with no side effects.
The Interrelation of Clarke’s Angle with Body Composition and Lower Extremity Explosive Muscle Strength in School-going Adolescents: A Cross-sectional Study
Authors: Darphang Dikshita , Deka Kuldeep , Karnad Shreekanth D. , Nayak Akshatha , Baidya Shalaka , Gogoi Nirmali , Rastogi Muskan
Published: January 2025

Introduction

Adolescence is a distinct period with many important physiological and behavioural changes, including alterations in body composition, changes in fitness attitudes, physical activity, and sedentary behaviour.

Aim of the Study

The primary purpose of this study was to characterize foot posture in school-aged adolescents aged 11-17 years, and to investigate the relationships between foot posture and body composition and lower extremity muscular explosive strength.

Materials and Methods

This cross-sectional study involved 150 school-going adolescents (11-17 years) who regularly participated in physical education classes and were assessed for their body composition, degree of flexible pes planus, and performance on the standing long jump test. The Spearman correlation coefficient was used to demonstrate the relationship between the degree of flatfoot and the standing long jump test.

Results

The median Clarke’s angle for the right foot for male and female participants was 420, whereas for the left side, it was measured as a median of 430 and 420 for females and males, respectively. The median standing long jump test distances for males and females were 154.0 and 116.5 centimetres, respectively. A clinically relevant correlation was not observed, as the ρ values were =0.03, R2=0.001 and ρ=0.05, R2=0.001 for the right and left Clarke's angles when associated with standing long jump test distance, and the same test had a weak correlation (ρ=0.145) with body composition.

Conclusion

This study has highlighted that flexible flat feet are not a challenging concern and do not interfere with performance in relation to lower extremity explosive muscle strength.
Implementation of peer-assessment system in speaking courses
Authors: Rochma Anis Firdatul , Suharso Suharso , Sudiyono Sudiyono , Fitriana Rahma
Published: January 2025

The ability to speak effectively refers to an individual’s capacity to convey thoughts and ideas orally. Various teaching strategies are employed to enhance speaking skills, with traditional methods primarily relying on teacher-driven assessments. However, incorporating peer assessment has emerged as a valuable approach that enables students to identify their strengths and areas for improvement, promoting the development of language proficiency, metacognitive awareness, and related skills. This study aims to implement peer assessment as an alternative evaluative method in the Speaking in Academic Contexts course, which includes both informative and persuasive speech tasks. Quantitative data were analyzed descriptively, with mean and standard deviation calculations comparing peer assessment scores to those assigned by the instructor. The Wilcoxon Signed Ranks Test was applied to determine statistically significant differences between the two sets of scores. Qualitative data, derived from students’ reflections, were analyzed using thematic analysis. Overall, students in the Speaking in Academic Contexts course reported positive perceptions of peer assessment, recognizing its potential to enhance their language skills and foster learner autonomy.
Exploring transference in the translation of proper names in Ratih Kumala’s Cigarette Girl
Authors: Juliartha Komang Rama , Hikmaharyanti Putu Desi Anggerina
Published: January 2025

This study explores the use of the transference translation procedure in translating proper names in the novel Cigarette Girl by Ratih Kumala. It aims to determine the frequency of transference translation procedure usage in translating proper names and to investigate the reasons behind the translator’s decision to retain certain names unmodified. Using a qualitative descriptive method, data were collected from the English and Indonesian versions of Cigarette Girl through observation and note-taking, then analyzed descriptively. The results indicate that the transference procedure was used a total of 62 times in translating proper names. The highest frequency of transference application was found in the categories of personal names and personifications, with a total of 30 instances. The lowest frequency was in the category of unique event names, with only one instance. The primary reason for using the transference procedure was to preserve the specific meanings embedded in the original names.
Analyzing Geospatial and Socioeconomic Disparities in Breast Cancer Screening Among Populations in the United States: Machine Learning Approach
Authors: Hashtarkhani Soheil , Zhou Yiwang , Kumsa Fekede Asefa , White-Means Shelley , Schwartz David L , Shaban-Nejad Arash
Published: January 2025

Background

Breast cancer screening plays a pivotal role in early detection and subsequent effective management of the disease, impacting patient outcomes and survival rates.

Objective

This study aims to assess breast cancer screening rates nationwide in the United States and investigate the impact of social determinants of health on these screening rates.

Methods

Data on mammography screening at the census tract level for 2018 and 2020 were collected from the Behavioral Risk Factor Surveillance System. We developed a large-scale dataset of social determinants of health, comprising 13 variables for 72,337 census tracts. Spatial analysis employing Getis-Ord Gi statistics was used to identify clusters of high and low breast cancer screening rates. To evaluate the influence of these social determinants, we implemented a random forest model, with the aim of comparing its performance to linear regression and support vector machine models. The models were evaluated using R2 and root mean squared error metrics. Shapley Additive Explanations values were subsequently used to assess the significance of variables and direction of their influence.

Results

Geospatial analysis revealed elevated screening rates in the eastern and northern United States, while central and midwestern regions exhibited lower rates. The random forest model demonstrated superior performance, with an R2=64.53 and root mean squared error of 2.06, compared to linear regression and support vector machine models. Shapley Additive Explanations values indicated that the percentage of the Black population, the number of mammography facilities within a 10-mile radius, and the percentage of the population with at least a bachelor’s degree were the most influential variables, all positively associated with mammography screening rates.

Conclusions

These findings underscore the significance of social determinants and the accessibility of mammography services in explaining the variability of breast cancer screening rates in the United States, emphasizing the need for targeted policy interventions in areas with relatively lower screening rates.
Explainable Predictive Model for Suicidal Ideation During COVID-19: Social Media Discourse Study
Authors: Bouktif Salah , Khanday Akib Mohi Ud Din , Ouni Ali
Published: January 2025

Background

Studying the impact of COVID-19 on mental health is both compelling and imperative for the health care system’s preparedness development. Discovering how pandemic conditions and governmental strategies and measures have impacted mental health is a challenging task. Mental health issues, such as depression and suicidal tendency, are traditionally explored through psychological battery tests and clinical procedures. To address the stigma associated with mental illness, social media is used to examine language patterns in posts related to suicide. This strategy enhances the comprehension and interpretation of suicidal ideation. Despite easy expression via social media, suicidal thoughts remain sensitive and complex to comprehend and detect. Suicidal ideation captures the new suicidal statements used during the COVID-19 pandemic that represents a different context of expressions.

Objective

In this study, our aim was to detect suicidal ideation by mining textual content extracted from social media by leveraging state-of-the-art natural language processing (NLP) techniques.

Methods

The work was divided into 2 major phases, one to classify suicidal ideation posts and the other to extract factors that cause suicidal ideation. We proposed a hybrid deep learning–based neural network approach (Bidirectional Encoder Representations from Transformers [BERT]+convolutional neural network [CNN]+long short-term memory [LSTM]) to classify suicidal and nonsuicidal posts. Two state-of-the-art deep learning approaches (CNN and LSTM) were combined based on features (terms) selected from term frequency–inverse document frequency (TF-IDF), Word2vec, and BERT. Explainable artificial intelligence (XAI) was used to extract key factors that contribute to suicidal ideation in order to provide a reliable and sustainable solution.

Results

Of 348,110 records, 3154 (0.9%) were selected, resulting in 1338 (42.4%) suicidal and 1816 (57.6%) nonsuicidal instances. The CNN+LSTM+BERT model achieved superior performance, with a precision of 94%, a recall of 95%, an F1-score of 94%, and an accuracy of 93.65%.

Conclusions

Considering the dynamic nature of suicidal behavior posts, we proposed a fused architecture that captures both localized and generalized contextual information that is important for understanding the language patterns and predict the evolution of suicidal ideation over time. According to Local Interpretable Model-Agnostic Explanations (LIME) and Shapley Additive Explanations (SHAP) XAI algorithms, there was a drift in the features during and before COVID-19. Due to the COVID-19 pandemic, new features have been added, which leads to suicidal tendencies. In the future, strategies need to be developed to combat this deadly disease.
A mixed methods study on user acceptability of STOP: a digital mental health intervention for paranoia. (Preprint)
Authors: Eid Laura , Kenny Alex , Jacobsen Pamela , Hsu Che Wei , Yiend Jenny
Published: January 2025

BACKGROUND

Cognitive bias modification for interpretation (CBM-I) is a technique to modify interpretation and used to reduce unhelpful negative biases. CBM-I has been extensively studied in anxiety disorders where interpretation bias has been shown to play a causal role in maintaining the condition. STOP (Successful Treatment of Paranoia) is a CBM-I digital smartphone app targeting interpretation bias in paranoia. It has been developed following research on the feasibility and acceptability of a computerized version. The current qualitative study extended that research by investigating the acceptability of STOP in individuals with paranoia. The study design and implementation were informed by the Evidence Standards Framework for Digital Health Technologies (DHTs) provided by the National Institute for Health and Care Excellence (NICE).

OBJECTIVE

The aim of the study was to involve service users in the design, development and testing of the smartphone app STOP and understand the degree of satisfaction with the current product. We aimed to establish the extent to which STOP met the NICE minimum and best practice standards for DHTs, specifically its acceptability to intended end users.

METHODS

Twelve participants experiencing mild to moderate levels of paranoia completed six weekly sessions of STOP before being invited to a feedback interview to share their experiences. Questions revolved around the acceptability of the application, perceived usefulness and barriers of the intervention as well as practicality and views around the use of a digital intervention in principle. Interviews were coded and analysed using the Framework analysis method to combine a deductive and inductive approach.

RESULTS

Framework analysis yielded six themes: STOP as an autonomous treatment; comparisons to other treatment options; the user experience of STOP (i.e. feelings towards and perceived usefulness of STOP); perceived impact on personal outcomes; design considerations (including recommendations for improvement); and therapeutic aspects of the core intervention.

CONCLUSIONS

STOP is a broadly acceptable intervention that was positively received by most participants. The current study findings are in line with the NICE Evidence Standards Framework for DHTs in that intended end users were involved in the development, design and testing of STOP and were mostly satisfied with it. These findings will contribute to the further iterative development of this intervention targeting interpretation bias in paranoia.

CLINICALTRIAL

https://doi.org/10.1186/ISRCTN17754650

INTERNATIONAL REGISTERED REPORT

RR2-10.1186/s13063-024-08570-3
What Worked? Understanding the Reasons for Reductions in Suicidal Thoughts and Negative Emotions After Visiting NowMattersNow.org (Preprint)
Authors: Fruhbauerova Martina , Huh David , Whiteside Ursula
Published: January 2025

BACKGROUND

As individuals experiencing suicidal thoughts increasingly turn to the internet for support, digital tools offer a scalable and accessible means to address this urgent need. Platforms like NowMattersNow.org, grounded in Dialectical Behavior Therapy (DBT) principles, have demonstrated reductions in suicidal ideation and negative emotions, suggesting the potential of web-based interventions in suicide prevention. However, further investigation is needed to identify which features of the website contribute most effectively to these outcomes.

OBJECTIVE

This study examines the impact of NowMattersNow.org, a web-based resource providing Dialectical Behavior Therapy-based skills and personal stories, on reducing suicidal thoughts and negative emotions in users. The goal was to identify reasons for these reductions and evaluate the resource’s effectiveness as online self-help.

METHODS

Data were collected from 3,185 respondents who completed a 7-item retrospective survey measuring changes in suicidal ideation and emotional distress. The survey, triggered after a preset time on the site, used a 1-5 scale to measure 'Intensity of suicidal thoughts' and 'Intensity of negative emotions' at baseline and post-visit. Longitudinal regression analyses evaluated the statistical significance of changes in these measures, while cross-tabulation identified reasons users found the site helpful.

RESULTS

Respondents reported a 0.5-point reduction in suicidal ideation (average 3.0 to 2.5) and a 0.62-point reduction in negative emotions (3.66 to 3.04). Among those with high baseline suicidal thoughts, 54.1% improved after viewing. LGBTQI individuals, those with substance use issues, and users reporting unusual experiences showed greater improvements compared to other groups. The most frequently cited reasons for improvement included “It distracted me,” “I felt less alone,” and “I learned something.”

CONCLUSIONS

The findings suggest that NowMattersNow.org is an accessible, scalable digital intervention that shows promise for reducing suicidal ideation and emotional distress, particularly in vulnerable populations. Key elements, such as fostering social connectedness, distraction, and educational content, appear to be critical components of its effectiveness, indicating that web-based self-help tools like NowMattersNow.org can provide short-term management of suicidal thoughts and negative emotions.

CLINICALTRIAL

NA
A Study of the Effect of Urban Comforts on the Willingness of Migrants to Stay in the City
Authors: Zhang Tian
Published: January 2025

As China's urbanisation process accelerates, more and more migrant populations are choosing to settle in cities, and studies affecting their willingness to stay are becoming increasingly diverse. In addition to traditional factors such as economic income and employment opportunities, the comfort of urban life has gradually become an important consideration influencing the choices of migrants. Based on social capital theory, ecosystem theory, social identity theory and social support theory, this paper focuses on the influence of urban comforts on the intention to stay of urban migrants, and explores the mechanism of urban comforts on the intention to stay of migrants. In the empirical study, this paper synthesises the urban comforts indicator based on the data collected at the city level and carries out a benchmark regression analysis, and the regression results show that urban comforts have a significant positive impact on the willingness to stay of the migrant population. In the individual heterogeneity analysis, it is found that urban comforts have a stronger effect on the willingness to stay of married migrants than unmarried or divorced migrants, and that urban comforts have a stronger effect on the willingness to stay of highly educated migrants than those with a low level of education. In the analysis of urban heterogeneity, it is found that the effect of urban comforts on the willingness to stay of the migrant population varies according to whether the city is in the east, middle and west of China, whether it is the Yangtze River Economic Belt, or whether it is a municipality directly under the central government. Based on this, this study proposes relevant policy recommendations.
A Comparative Study of Physical Education and Health Outcomes in China, Japan, and India
Authors: Mathew Framcy
Published: January 2025

Abstract: This research paper provides a comparative analysis of physical education (PE) curriculums and health outcomes
among young adults in China, Japan, and India. By examining the objectives, content, and implementation strategies of the
physical education programs in these countries, along with statistical data on the health of young adults, this study highlights
the similarities and differences in their approaches. The findings emphasize the need for a balanced and culturally sensitive
physical education curriculum to promote lifelong fitness and well-being.
A Review Study on Effects of Multimodal Therapy on Hamstrings Tightness – A Systemic Review
Authors: Jayaraj Joji , Dash Smruti Swagatika , Kachhwaha Rajendra
Published: January 2025

Background: Hamstring tightness is a prevalent musculoskeletal condition affecting individuals across various age groups and activity levels. It often leads to reduced flexibility, increased injury risk, and impaired functional performance. Multimodal therapy, which combines various therapeutic interventions, has been proposed as an effective approach for managing hamstring tightness. However, the cumulative evidence supporting its efficacy remains unclear.
Objective: This systematic review aims to evaluate the effects of multimodal therapy on hamstring tightness by synthesizing findings from recent studies to determine its clinical relevance and effectiveness.
Methods: Inclusion criteria encompassed randomized controlled trials, cohort studies, and comparative studies investigating multimodal interventions for hamstring tightness. Multimodal therapy was defined as the combination of two or more therapeutic techniques, such as stretching, manual therapy, strengthening exercises, and physical modalities.
Results: Common combinations included static stretching with myofascial release, dynamic stretching with eccentric strengthening, and neuromuscular facilitation with cryotherapy.
Conclusion: Multimodal therapy is a highly effective approach for alleviating hamstring tightness, surpassing the efficacy of standalone techniques. The integration of stretching, manual therapy, and neuromuscular training yields superior outcomes in flexibility and functional performance. Future research should explore the long-term effects of these interventions and establish standardized protocols for clinical practice.
PELATIHAN PENYUSUNAN PROPOSAL SKRIPSI MAHASISWA SEBAGAI UPAYA MENGHASILKAN PENELITIAN YANG BERKUALITAS
Authors: Mustofa Meihan Andre , Robbi Kurniawanti Merci , Yosephine Sinurat Junita , Hajri Priazki
Published: January 2025

Training in preparing student thesis proposals is a very strategic activity to improve students' abilities in designing relevant and quality research and of course has many positive benefits for students. The method used in this service activity is to deliver material directly and provide assistance to Jambi University History Education Study Program students in designing a quality thesis proposal. The results of this training have been said to be successful because the participants were able to prepare research proposals well and in accordance with the thesis writing guidelines at Jambi University. With an average score of 82 in the A category.
The Applicability of Represented Local Oral History for the Tourism Resource Development of Local History: Focusing on a Comparative Analysis of Anchang Tiger Village and Tombstone Culture Village in Busan
Authors:   The Convergence Tourism Contents Society, Kim Ok Hee , Yang Soung Hoon
Published: January 2025

Purpose: This study conducted an exploratory study to implement the full-scale development of local oral history as a tourism resource. The study compared the possibility of developing oral history as a local tourism resource for the Anchang Tiger Village and the Tombstone Culture Village in Busan and discussed the importance of the process of visual representation of their oral history. The two villages are underdeveloped compared to other areas in downtown Busan among domestic areas but possess modern historical resources.
Methods: The study observed and analyzed the exhibition status of historical resources in the two research sites that could be developed into oral history tourism content and the activities of visiting tourists to see those resources of these villages. In the process, analysis was conducted by visiting and photographing places where local historical resources were specifically represented.
Results: The result shows that discovering and developing the representation of local oral history helps recognize the diversity of local culture and can be applicable as an important strategy for local tourism resource development with a convergence that combines history and tourism.
Conclusion: The representation of local oral history is expected to remove restrictions on tourism activities for visitors to local areas by maintaining the invisible historical existence of the areas while visualizing it, and contribute to increasing the value of local community culture.
Analysis of Subjective Perception between Korean University Students and International Students Majoring in Hotel and Tourism Using the Q Methodology
Authors:   The Convergence Tourism Contents Society, Dan Hyo Ju , Jin Jin Hee
Published: January 2025

Purpose: The purpose of this study is to analyze the subjective perceptions between Korean university students and international students majoring in hotel and tourism.
Methods: This study applied Q methodology to analyze the subjective perceptions of Korean university students and international students majoring in hotel and tourism. The Q-sample consisted of 30 items based on previous studies, and the P-sample consisted of 20 Korean university students and 20 international students majoring in hotel and tourism who were enrolled in 4-year universities or colleges (operating 3rd or 4th year specialized course) located in the metropolitan area.
Results: As a result, first, the subjective perception types of Korean university students were derived as type 1(growing together), type 2(recognizing and overcoming differences), and type 3(feeling psychological distance). Second, the subjective perception types of international students were derived as type 1(wanting to approach and become close to), type 2(feeling gratitude for help), type 3(coexisting admiration and hurt).
Conclusion: This study is an initial study that analyzes the subjective perceptions of Korean university students and international students majoring in hotel and tourism, and is expected to serve as a foundation for follow-up studies. In addition, this study is expected to suggest multicultural education plans by type based on the analysis results.
Maska „nasmijanog dobričine”. Pokušaj portreta Emanuela (Manka) Gagliardija
Authors: Stipančević Mario
Published: January 2025

Prilog pokušava približiti životnu priču Emanuela Gagliardija (1885. – 1942.), neobične figure zagrebačkoga „svijeta u malom” kraja XIX. i prve polovine XX. stoljeća, o kojem se u domaćoj publicistici i historiografiji rijetko raspravljalo. Budući da je riječ o osobi vrlo burnoga opusa povezanoj s vojnom, redarstvenom, doušničkom i političkom sastavnicom društva, većina se poznatih podataka oslanjala na teško provjerljive bilješke suvremenika koje su ga gotovo beziznimno držale negativnom ličnošću. Ti su se navodi na temelju raspoloživih vrela nastojali potvrditi ili osporiti. Pored spomenutog, koliko je poznato, u tekstu se prvi put široj javnosti podastiru i fotografski prikazi njegova glavnoga aktera.
Etiological structure and profile of antimicrobial resistance of pathogens in bacteremia in COVID-19 patients
Authors: Gusev D. A. , Musatov V. B. , Karnaukhov E. V. , Zhdanov K. V. , Gordeeva S. A. , Pavlov A. V.
Published: January 2025

Goal. To investigate the spectrum of microorganisms, the level of antimicrobial resistance and to assess their effect on the outcomes of bacteremia among COVID­19 patients.

Materials and methods. A retrospective analysis of potentially resistant bacteria detected in blood and the mortality rate among COVID­19 patients and patients with other diagnoses in the period from 01.01. – 12/31/2020.

Results. In total, the analyzed pathogens were isolated from 168 patients, including 101 COVID­19 patients (group 1) and 67 patients with other diagnoses (group 2). Bloodstream infection were more often detected among COVID­19 patients (12.6 and 2.6 cases per 1000 patients, p<0.05). In group 1, the proportion of gram­-negative pathogens was higher than in group 2 (63.8% and 52.1%, p=0.012). The most commonly pathogen in group 1 is K. pneumoniae (31.5%, 41 cultures), in group 2 – S. aureus (35.2%, 25 cultures). Of particular importance is the identification of A. baumannii (32 and 4 cultures, p<0.001) and E. faecium (24 and 4 cultures, p=0.003) in group 1; S. aureus (25 and 11 cultures, p<0.001) and E. coli (9 and 6 cultures, p=0.038) – in group 2. Three leading types of microorganisms in group 1 have a high level of resistance: 96.9% of A. baumannii and 81.6% of K. pneumoniae were resistant to carbapenems, 36.8% of E. faecium was VRE. In group 1, several (22.8% and 6.0%, p=0.004) and resistant (70.3% and 41.8%, p<0.001) microorganisms were detected more frequently. The mortality rate of patients was higher in group 1 (68.3% and 50.7%, p=0.022). The occurrence of a bloodstream infection caused by a potentially resistant microorganism in COVID­19 patients is an unfavorable factor in the onset of death (p=0.022).

Conclusion. COVID­19 patients with bacteremia have a high level of polymicrobial associations with a predominance of gram­-negative bacteria both in their composition and as a monoinfection. The isolated microorganisms have a high level of antimicrobial resistance, which must be taken into account when choosing antibiotics.