bluuebunny/crossref_metadata_2025 huggingface dataset:
Nationally representative estimates of the participation of cancer patients in clinical research studies according to the commission on cancer.
Authors: Unger Joseph M. , Fleury Mark
Published: September 2021

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Background: The successful conduct of cancer clinical trials hinges on the willingness of patients to participate. The rate of adult clinical trial participation has been regarded as being < 5%. However, national estimates of trial participation are nearly two decades old, and no evidence based on original data sources has been examined for many years. Moreover, studies about trial participation have focused solely on enrollment to treatment trials, which does not reflect the willingness of patients to contribute to other key elements of clinical research, such as quality of life or biorepository studies. We determined inclusive, contemporary estimates of clinical trial participation for adults with cancer using a national sample of data from 1,200 institutions. Methods: The data were from the Commission on Cancer (CoC), a consortium of cancer-related organizations providing accreditation for both academic and community cancer care facilities across the U.S. CoC enrollment data represent 70% of all cases of cancer diagnosed each year. Deidentified, institution-level aggregate counts of annual enrollment to treatment, biorepository, diagnostic, economic, genetic, prevention, quality of life, registry, and screening studies were examined. Overall, study-type estimates for the period 2013-2017 were estimated. Multiple imputation by chained equations was used to account for missing data, with summary estimates calculated separately by type of program (e.g., NCI-designated cancer programs) and pooled. Results: Across the entire U.S. system, the estimated participation rate to cancer treatment trials was 6.3%. Enrollment to treatment trials was highest at NCI-designated comprehensive cancer centers (18.9%), while for community cancer programs (CCPs) and comprehensive CCPs, treatment trial rates were 4.4% and 3.6%, respectively. Nearly 1 in 7 patients participated in biorepository studies (13.4%), including 39.4% at NCI cancer centers. Patients participated in a wide variety of other study types, including registry (8.1%), prevention (6.4%), genetic (3.6%), quality of life (2.9%), economic (2.7%), diagnostic (2.7%), and screening studies (1.8%). At least 25.4% of adult cancer patients were estimated to participate in one or more cancer clinical research studies. Conclusions: In a first-time use of nationally representative enrollment data from the CoC, enrollment to cancer treatment trials was 6.3%, higher than historical estimates of < 5%. Patients participated in a diverse set of other study types, and taken together, at least one quarter of patients participated in a study. Contributions of adult patients with cancer to clinical research is much more comprehensive than previously understood.
Abrogation of survival disparity between insured and uninsured individuals after the USPSTF's 2012 prostate-specific antigen-based prostate cancer screening recommendation.
Authors: Kim Isaac Elijah , Kim Daniel D. , Kim Sinae , Singer Eric A. , Jang Thomas L. , Ghodoussipour Saum , Aron Monish , Kim Isaac Yi
Published: September 2021

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Background: In 2012, the U.S. Preventive Services Task Force (USPSTF) recommended against prostate-specific antigen (PSA)-based screening for prostate cancer. Studies have found that insured patients with prostate cancer have better outcomes than uninsured patients. We examined the recommendation’s effects on survival disparities based on insurance status as well as socioeconomic quintile, marital status, and housing (urban/rural). Methods: Using the SEER18 database, we examined prostate cancer-specific survival (PCSS) based on diagnostic time period and one of four factors: insurance status, socioeconomic quintile, marital status, and housing (urban/rural). The SEER-designated socioeconomic quintile was based on variables including median household income and education index. Patients were designated as belonging to the pre-USPSTF era if diagnosed in 2010-2012 or post-USPSTF era if diagnosed in 2014-2016. Disparities were measured with the Cox proportional hazards model. Results: We identified 282,994 patients diagnosed with prostate cancer. During the pre-USPSTF era, uninsured patients experienced worse PCSS compared to insured patients (adjusted HR 1.29, 95% CI 1.06-1.58, p = 0.01). This survival disparity narrowed during the post-USPSTF era as a result of decreased PCSS among insured patients combined with unchanged PCSS among uninsured patients. Moreover, the survival disparity was no longer observed during the post-USPSTF era (aHR 0.91, 95% CI 0.61-1.38, p = 0.67). The survival disparity based on socioeconomic quintile also narrowed but remained significant. In contrast, the survival disparity based on marital status widened, while housing status was not associated with survival disparities in either era. Conclusions: From the pre- to the post-USPSTF era, insured patients with prostate cancer observed a significant decrease in survival that made their survival outcomes similar to that of uninsured patients. Although the underlying reasons are not clear, the USPSTF’s 2012 PSA screening recommendation may have hindered insured patients from being regularly screened for prostate cancer and selectively led to worse outcomes for insured patients without improving the survival of uninsured patients.[Table: see text]
Association of rurality and race with surgical treatment and outcomes for nonmetastatic colon cancer.
Authors: Ramkumar Niveditta , Colla Carrie , Wang Qianfei , O'Malley James , Wong Sandra L. , Brooks Gabriel A.
Published: September 2021

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Background: Rural cancer patients face limited access to care due to greater travel distance and lack of specialty cancer care. Little is known about the intersection of rurality with well-documented racial disparities in colon cancer treatment and outcomes. Methods: We used fee-for-service Medicare claims to study patients age 65+ diagnosed with incident colon cancer without evidence of metastases who underwent cancer-directed surgery between 04/01/2016 and 09/30/2018. The primary exposure wasrurality of patient’s residence categorized as metropolitan (metro), micropolitan, and small town/rural. Outcomes were non-elective surgery (emergency department visit or transfer within 2 days prior to surgery), receipt of minimally invasive surgery (laparoscopic or robotic), 90-day surgical complications, and 90-day mortality. Logistic regression adjusted for patient demographics, cancer side (right vs left), comorbidities, and Area Deprivation Index. We assessed effect modification by race/ethnicity. Results: Of 57,710 patients with incident non-metastatic colon cancer, 37,691 (65%) underwent surgery. In this surgical cohort, small town/rural and micropolitan residents were more likely to be older, white, and Medicare-Medicaid dual-eligible than metro residents. After risk adjustment, patients in small town/rural areas had higher odds of non-elective surgery (OR =1.24, 95% CI:1.13-1.36) and lower odds of minimally invasive surgery (OR = 0.75, 95% CI:0.71-0.80) than patients living in metro areas. Similar results were seen for micropolitan areas. White rural patients had lower mortality than white urban patients, whereas black rural patients had higher mortality than black metro patients (see Table). Increasing area deprivation was associated with higher odds of non-elective surgery, surgical complications and mortality, and lower odds of minimally invasive surgery, even after adjusting for race and rurality. Conclusions: Small town/rural-residing Medicare beneficiaries undergoing surgery for non-metastatic colon cancer were less likely to receive optimal surgical management and had worse outcomes, especially among non-white patients. The compounded effect of rurality, race/ethnicity, and social deprivation should be incorporated in developing policies and interventions to improve care for rural cancer patients.[Table: see text]
Improving hematology/oncology clinical research recruitment via universal prescreening: The VA Connecticut (VACT) Cancer Center experience.
Authors: Xiang Jenny Jing , Roy Alicia , Summers Christine , Delvy Monica , O'Donovan Jessica Lee , Christensen John , Perry Lydia , Connery Donna , Rose Michal G. , Chao Herta H.
Published: September 2021

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Background: Patient-trial matching is a critical step in clinical research recruitment that requires extensive review of clinical data and trial requirements. Prescreening, defined as identifying potentially eligible patients using select eligibility criteria, may streamline the process and increase study enrollment. We describe the real-world experience of implementing a standardized, universal clinical research prescreening protocol within a VA cancer center and its impact on research enrollment. Methods: An IRB approved prescreening protocol was implemented at the VACT Cancer Center in March 2017. All patients with a suspected or confirmed diagnosis of cancer are identified through tumor boards, oncology consults, and clinic lists. Research coordinators perform chart review and manually enter patient demographics, cancer type and stage, and treatment history into a REDCap (Research Electronic Data Capture) database. All clinical trials and their eligibility criteria are also entered into REDCap and updated regularly. REDCap generates real time lists of potential research studies for each patient based on his/her recorded data. The primary oncologist is alerted to a patient’s potential eligibility prior to upcoming clinic visits and thus can plan to discuss clinical research enrollment as appropriate. Results: From March 2017 to December 2020, a total of 2548 unique patients were prescreened into REDCAP. The mean age was 71.5 years, 97.5% were male, and 15.5% were African American. 32.57 % patients had genitourinary cancer, 17.15% had lung cancer, and 46.15% were undergoing malignancy workup. 1412 patients were potentially eligible after prescreening and 556 patients were ultimately enrolled in studies. The number of patients enrolled on therapeutic clinical trials increased after the implementation of the prescreening protocol (35 in 2017, 64 in 2018, 78 in 2019, and 55 in 2020 despite the COVID19 pandemic). Biorepository study enrollment increased from 8 in 2019 to 15 in 2020. The prescreening protocol also enabled 200 patients to be enrolled onto a lung nodule liquid biopsy study from 2017 to 2019. Our prescreening process captured 98.57% of lung cancer patients entered into the cancer registry during the same time period. Conclusions: Universal prescreening streamlined research recruitment operations and was associated with yearly increases in clinical research enrollment at a VA cancer center. Our protocol identified most new lung cancer patients, suggesting that, at least for this malignancy, potential study patients were not missed. The protocol was integral in our program becoming the top accruing VA site for NCI’s National Clinical Trial Network (NCTN) studies since 2019.
Disaggregating Pacific Islanders and major Asian subpopulations to reveal hidden breast cancer disparities.
Authors: Taparra Kekoa , Dee Edward Christopher , Dao Dyda , Patel Rohan , Santos Patricia Mae G. , Chino Fumiko
Published: September 2021

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Background: The Asian American, Native Hawaiian, and Other Pacific Islander (AA/NHPI) population is the fastest growing and most socioeconomically heterogeneous racial/ethnic group in the US. AA/NHPI breast cancer outcomes are often reported as superior to Non-Hispanic Whites (NHW) however evidence suggests aggregating AA/NHPI masks disparities among subpopulations. As NHPI is often ignored as one of five official US races, this study aims to disaggregate AA and NHPI to unmask breast cancer disparities. Methods: An IRB exempt, retrospective cohort study using the National Cancer Database was conducted for women diagnosed with breast cancer in 2004-2016. AA and NHPI patients were compared with the majority NHW group. AA was separated into pertinent geographical origins: East Asian (EA; Chinese, Japanese, Korean), South Asian (SA; Indian, Pakistani), and Southeast Asian (SEA; Filipino, Vietnamese, Laotian, Hmong, Cambodian). Descriptive statistics were used. Logistic and Cox proportional hazard regressions assessed adjusted Odds Ratios (aORs) and adjusted Hazards Ratios (aHR), respectively, with 95% confidence intervals (95%CI). Analyses were adjusted for patient factors (age, insurance, income, rural/urban, education, hospital region, hospital distance, Deyo comorbidity score) and cancer characteristics (grade, stage, metastases, diagnosis year, hormone status). Results: Of 2,073,822 women there were 28,311 EA, 13,259 SA, 21,645 SEA, 5,375 NHPI, and 2,005,232 NHW. The median age was 62 years with median 66 month follow-up. Compared to NHW (9.6%), presentation with late-stage disease (Stage III/IV) was higher in NHPI (12%), SA (12%), and SEA (11%), but not EA (7.5%). On adjusted analysis (Table), EA was the only group with a statistical difference from NHW with aOR=0.85 (95%CI=0.76-0.94). Kaplan-Meier test for overall survival (OS) showed differences between ethnic/racial groups with NHPI having worse OS than AA subpopulations (p<0.0001). On adjusted analysis (Table), all AA subpopulations had lower risk of death compared to NHW: EA (aHR=0.69; 95%CI=0.64-0.74), SA (aHR=0.65; 95CI=0.59-0.71), and SEA (aHR=0.78; 95%CI=0.73-0.84) however the NHPI group had a greater risk of death (aHR=1.14; 95%CI=1.02-1.28). Conclusions: NHPI women with breast cancer have worse outcomes compared to NHW. This is masked by superior AA outcomes when aggregated. The continual improper aggregation of AA with NHPI downplays NHPI cancer disparities. Proper disaggregation of NHPI from AA warrants greater attention.[Table: see text]
The association of access to systemic therapy and overall survival in metastatic bladder cancer in Russia: An analysis of URRU register.
Authors: Petkau Vladislav , Alekseeva Galina , Zukov Ruslan , Mazhbich Mikhail , Statsenko Galina , Vladimirova Liubov Yu , Novikova Olga , Semenov Andrey , Zaitsev Igor , Gurina Ludmila , Tsimafeyeu Ilya
Published: September 2021

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Background: Social, economic and community disadvantages are well-described for metastatic bladder cancer (mBC) in different geographical regions. For the first time in Russian Federation we investigated treatment options and survival disparities for patients with mBC including urothelial cancer in URRU register. Methods: Patients were retrospectively identified at 9 cancer centers in southern, central, and eastern regions of Russia (Astrakhan, Ekaterinburg, Ivanovo, Khabarovsk, Krasnoyarsk, Moscow, Omsk, Rostov-on-Don, Vladivostok). Patients were included in the study if histologically confirmed mBC was diagnosed between January 2017 and January 2018 and they had at least one visit to the cancer center during the follow-up period. Anonymised data were collected by online registry. The outcomes of interest were overall survival (OS), patient characteristics and treatment patterns. Results: 246 adult patients were included in the study for analysis. Mean number of patients in one region per year was 31. All patients had metastatic disease. Median age at diagnosis of mBC was 72 (37-99) years (with 60.6% of patients aged ≥70 years). Patients were predominantly male (75%), histological subtype of BC (urothelial carcinoma, etc.) was determined in 70.32%. 92 (37.4%) patients received systemic therapy for mBC. Despite the approved checkpoint inhibitors for mBC in 2017-2018 in Russia the main treatment option was chemotherapy (n=70; 76%). Multivariate analysis by adjusting demographic and cancer variables showed that non-receipt of systemic therapy was independently associated with higher odds of death (Odds Ratio=3.1, confidence interval (CI)=1.89 to 5.18). Median OS (21 months; 95% CI 17.38-24.62) of patients who received systemic therapy was significantly longer than that of patients who did not received the therapy (3 months; 95% CI 1.79-4.22; p<0.0001). Patients receiving immunotherapy had better survival outcomes comparing to chemotherapy (median OS 34.5 vs. 18 months, p=0.003). Conclusions: In Russia only one third of patients with mBC received systemic therapy for metastatic disease which affected OS. Consistent with other studies these results indicate that patients should have access to novel therapies.
Interdisciplinary clinician perspectives on an embedded palliative oncology model in pediatric cancer care.
Authors: Salek Marta , Woods Cameka , Gattuso Jami S. , Mandrell Belinda Neal , Baker Justin N. , Kaye Erica
Published: September 2021

9

Background: Integration of palliative care into cancer care is recognized as best practice by international oncology and pediatrics organizations. However, optimal strategies for integration of pediatric palliative care (PPC) within cancer care remain understudied. While the majority of PPC provision for cancer patients occurs through subspeciality consultation, growing evidence suggests that models embedding PPC within cancer care have the potential to improve quality of care. Embedded models rely on partnerships with multidisciplinary clinicians, whose perspectives regarding this model are not well known. Methods: We conducted 25 focus groups with 175 clinicians in an academic pediatric cancer center, with groups stratified by discipline (physicians, advance practice providers (APPs), nurses, psychosocial providers) and by care team (hematologic malignancy, bone marrow transplant, solid tumor, brain tumor). Focus groups were led by trained research facilitators and audio-recorded for subsequent targeted content analysis to identify clinician perspectives regarding embedded PPC models. Results: Across 4 physician, 5 APP, 12 nurse, and 4 psychosocial focus groups, 25 physicians, 30 APPs, 71 nurses, and 49 psychosocial providers participated, respectively. When asked to describe features of an “ideal” PPC model, physicians, APPs, and nurses predominantly discussed care delivery and identified early integration of PPC into cancer care as a core feature of an ideal model. Physicians, nurses, and psychosocial providers also emphasized the importance of having a formalized, structured care model. The need for collaboration was the dominant theme for psychosocial providers. Clinicians in all disciplines identified potential benefits from an embedded model, including access to PPC across care settings, normalization of PPC integration, and emphasis on collaboration, teamwork, communication, and earlier PPC involvement. Physicians, APPs, and nurses anticipated similar challenges with an embedded model, including possible reticence of oncology providers and inadequate PPC staffing. Nurses, APPs, and psychosocial providers also voiced concern about potential lack of clarity in delegation of roles and responsibilities between PPC and oncology providers. Conclusions: Pediatric oncology multidisciplinary providers recognize the potential value of an embedded model for integration of PPC in the care of children with cancer. Though providers at times identified similar themes with respect to ideal PPC provision and the benefits and challenges to an embedded model, some identified priorities varied by discipline. These findings highlight the importance of integrating varied interdisciplinary perspectives when developing an embedded care model to align with priorities of diverse pediatric cancer stakeholders.
The Cortisol Response of Male and Female Choroidal Endothelial Cells: Implications for Central Serous Chorioretinopathy
Authors: Brinks Joost , van Dijk Elon H C , Kiełbasa Szymon M , Mei Hailiang , van der Veen Isa , Peters Hendrika A B , Sips Hetty C M , Notenboom Robbert G E , Quax Paul H A , Boon Camiel J F , Meijer Onno C
Published: September 2021

Context

Central serous chorioretinopathy (CSC) is a severe ocular disease characterized by fluid accumulation under the retina and abnormalities in the underlying vascular layer, the choroid. CSC has a striking prevalence in males of 80% to 90% of total patients. Corticosteroids are the most pronounced extrinsic risk factor for CSC. Choroidal endothelial cells (CECs) are important for the vascular integrity of the choroid, but the effects of corticosteroid effects in these cells are unknown.

Objective

We aimed to reveal the potential steroidal contribution to CSC.

Method

We characterized the expression of the glucocorticoid, mineralocorticoid, and androgen receptor in the human choroid using immunohistochemistry. Using RNA-sequencing, we describe the cortisol response in human CECs derived from 5 male and 5 female postmortem donors.

Results

The glucocorticoid receptor was highly expressed in the human choroid, whereas no to minimal expression of the mineralocorticoid and androgen receptors was observed. The extensive transcriptional response to cortisol in human primary cultured CECs showed interindividual differences but very few sex differences. Several highly regulated genes such as ZBTB16 (log2 fold change males 7.9; females 6.2) provide strong links to choroidal vascular regulation.

Conclusions

The glucocorticoid receptor predominantly mediates the response to cortisol in human CECs. Interindividual differences are an important determinant regarding the cortisol response in human cultured CECs, whereas intrinsic sex differences appear less pronounced. The marked response of particular target genes in endothelial cells to cortisol, such as ZBTB16, warrants further investigation into their potential role in the pathophysiology of CSC and other vascular conditions.
Regulation of cell quiescence–proliferation balance by Ca2+–CaMKK–Akt signaling
Authors: Xin Yi , Guan Jian , Li Yingxiang , Duan Cunming
Published: September 2021

Compared with our extensive understanding of the cell cycle, we have limited knowledge of how the cell quiescence–proliferation decision is regulated. Using a zebrafish epithelial model, we report a novel signaling mechanism governing the cell quiescence–proliferation decision. Zebrafish Ca2+-transporting epithelial cells, or ionocytes, maintain high cytoplasmic Ca2+ concentration ([Ca2+]c) due to the expression of Trpv6. Genetic deletion or pharmacological inhibition of Trpv6, or reduction of external Ca2+ concentration, lowered the [Ca2+]c and reactivated these cells. The ionocyte reactivation was attenuated by chelating intracellular Ca2+ and inhibiting calmodulin (CaM), suggesting involvement of a Ca2+ and CaM-dependent mechanism. Long-term imaging studies showed that after an initial decrease, [Ca2+]c gradually returned to the basal levels. There was a concomitant decease in endoplasmic reticulum (ER) Ca2+ levels. Lowering the ER Ca2+ store content or inhibiting ryanodine receptors impaired ionocyte reactivation. Further analyses suggest that CaM-dependent protein kinase kinase (CaMKK) is a key molecular link between Ca2+ and Akt signaling. Genetic deletion or inhibition of CaMKK abolished cell reactivation, which could be rescued by expression of a constitutively active Akt. These results suggest that the quiescence–proliferation decision in zebrafish ionocytes is regulated by Trpv6-mediated Ca2+ and CaMKK–Akt signaling.
Interventions to improve neurodevelopmental outcomes of children born moderate to late preterm: a systematic review protocol
Authors: Agyeman-Duah Josephine , Kennedy Stephen , O'Brien Frances , Natalucci Giancarlo
Published: September 2021

Introduction: Prematurity (birth before 37+0 weeks’ gestation) is associated with wide-ranging neurodevelopmental impairment. Prognosis among moderate to late (32+0 to <37+0  weeks’ gestation) preterm infants (MLPT) is better compared to their counterparts born very preterm (<32+0  weeks’ gestation). However the risk of developmental impairment among MLPT, who make up about 84% of all preterm infants, is 2-3 times higher when compared to infants born at term.

Early interventions have aimed to improve outcomes in preterm infants generally, but there are limited data on their need and effect in MLPT specifically. Prioritising research, long-term follow-up and early interventions targeted at ameliorating the impact of preterm birth among MLPT is required.

Objectives: To conduct a systematic review of the type of early childhood interventions (from birth until 4 years of age) offered to  MLPT children and to evaluate their impact on neurodevelopmental outcomes (cognitive, neurobehavioural and motor) as assessed in these children during childhood (until 18 years of age).

Methods and analysis: A systematic literature search in Web of Science, Medline Ovid, PsycINFO, CINAHL and EMBASE will be conducted. Data on MLPT children receiving developmental interventions until the age of 4 years will be evaluated. Interventions may involve parents or primary caregivers. Primary outcomes are cognitive, neurobehavioural and motor development as measured from birth until the age of 18 years.

The Cochrane Risk of Bias Assessment Tool will be used to evaluate the methodological quality of randomised controlled trials (RCTs) included in the review and will be graded as low, high  or unclear risk of bias. The quality of non-RCTs will be evaluated with the Newcastle-Ottawa Scale. The quality of evidence for each outcome will be evaluated using the Grading of Recommendations Assessment, Development and Evaluation Approach. Publication and reporting bias will be assessed using Egger’s test and funnel plots respectively.
Critical Kirchhoff-Choquard system involving the fractional $p$-Laplacian operator and singular nonlinearities
Authors: Sang Yanbin
Published: September 2021

In this paper we study a class of critical fractional $p$-Laplacian Kirchhoff-Choquard systems with singular nonlinearities and two parameters $\lambda$ and $\mu$. By discussing the Nehari manifold structure and fibering maps analysis, we establish the existence of two positive solutions for above systems when $\lambda$ and $\mu$ satisfy suitable conditions.
Il Nuovo Testamento Greco-Latino-Italiano – Conferenza Episcopale Italiana, Roma, 2020
Authors: Bertalot Valdo
Published: September 2021

On the same day of the United Nations International Translation Day, the 30th of September 2020, Il Nuovo Testamento Greco-Latino-Italiano was published by the Italian Catholic Bishops’ Conference (CEI), a date chosen by the United Nations in honor of St. Jerome. The publication of the NTGLI presents two specific innovations: 1. at a ‘textual’ level for the most recent editions of the New Testament used (The Greek New Testament-5th Revised edition; Nova Vulgata, Bibliorum Sacrorum Editio, Editio typica altera; La Sacra Bibbia - Versione ufficiale della Conferenza Episcopale Italiana) and 2. at a ‘cultural’ level for the cooperation among different Christian confessions in Bible translating. In 1988 the Conferenza Episcopale Italiana initiated an extensive and in-depth revision of the CEI1971-74 Bible based on the most recent critical editions of the original Hebrew and Greek texts. The new CEI Bible was published in 2008. Created for the liturgical use, with its 1971-74 edition the CEI Bible became the reference text, almost a new Vulgata. The NTGLI is a strategic tool for future translations of the New Testament in the 4,000 languages without a Bible translation, also aiming to contribute to the affirmation of peace for humanity, as stated in the United Nations Charter: “United Nations Charter, Chapter I, Purposes and Principles, Article 1: The Purposes of the United Nations are: To maintain international peace and security...[and] to develop friendly relations among nations based on respect for the principle of equal rights and self-determination of peoples…”
Calidad ambiental y crecimiento económico: análisis dinámico para América Latina y el Caribe
Authors: Segarra Verónica , Olivera Martín
Published: September 2021

Este trabajo estudia la relación dinámica entre las emisiones de dióxido de carbono y el crecimiento económico para un grupo de países de América Latina y el Caribe durante el período 1951-2014. A partir del uso de regímenes económicos y simbolización de series temporales, se introduce una métrica y mediante el análisis de clusters se encuentran dos grupos diferenciados en términos de su dinámica de emisiones y crecimiento. Se analiza la existencia de relaciones bidireccionales tanto de corto como de largo plazo, encontrando que la relación difiere según los grupos y los métodos de estimación.
Predicting Tactical Solutions to Operational Planning Problems Under Imperfect Information
Authors: Larsen Eric , Lachapelle Sébastien , Bengio Yoshua , Frejinger Emma , Lacoste-Julien Simon , Lodi Andrea
Published: September 2021

This paper offers a methodological contribution at the intersection of machine learning and operations research. Namely, we propose a methodology to quickly predict expected tactical descriptions of operational solutions (TDOSs). The problem we address occurs in the context of two-stage stochastic programming, where the second stage is demanding computationally. We aim to predict at a high speed the expected TDOS associated with the second-stage problem, conditionally on the first-stage variables. This may be used in support of the solution to the overall two-stage problem by avoiding the online generation of multiple second-stage scenarios and solutions. We formulate the tactical prediction problem as a stochastic optimal prediction program, whose solution we approximate with supervised machine learning. The training data set consists of a large number of deterministic operational problems generated by controlled probabilistic sampling. The labels are computed based on solutions to these problems (solved independently and offline), employing appropriate aggregation and subselection methods to address uncertainty. Results on our motivating application on load planning for rail transportation show that deep learning models produce accurate predictions in very short computing time (milliseconds or less). The predictive accuracy is close to the lower bounds calculated based on sample average approximation of the stochastic prediction programs.
Combination of Discovery Learning and Metacognitive Knowledge Strategy to Enhance Students’ Critical Thinking Skills
Authors: Nusantari Elya , Abdul Aryati , Damopolii Insar , Alghafri Ali Salim Rashid , Bakkar Bakkar Suleiman
Published: September 2021

The research aims to develop an instructional tool based on Discovery Learning (DL) combined with a Metacognitive Knowledge Strategy (MKS) to enhance students’ Critical Thinking Skills (CTSs). In doing so, the study employed a Research and Development (R&D) method to develop such a tool. The developed instructional tool was tested for its validity by experts and practitioners’ evaluation. Further, the empirical data were collected from the results of implementation in learning and the student's responses, while the data of tools effectiveness were acquired from the critical thinking tests given to students (analyzed by related t-test). The developed instructional tools were implemented in a limited-scale trial of 32 students and a large-scale trial of 59 students. The results show that: firstly, the DL and MKS-integrated instructional tools are stated as valid in terms of the lesson plan, student worksheet, and critical thinking test. Secondly, the practicality criteria have been successfully met; the learning implementation, students’ activity, and students' responses were regarded as in accordance with the feasibility standard. Thirdly, the instructional tool was deemed effective in enhancing students’ CTSs (p = 0.05).
Equalization Access to Education as an Effort to Foster the Nationalism of Indonesian Migrant Workers’ Children in Border Areas
Authors: Suarno Dendi Tri , Suryono Yoyon , Zamroni Zamroni
Published: September 2021

The discussion about the loss of nationalism values in the Indonesian migrant workers’ (IMW’s) children in border areas, has become an important issue in the world of Indonesian education. The purpose of this study is to describe the role of Community Learning Center (CLC) in fostering nationalism values in IMW’s children, as well as to reveal the teaching experience and meaning of nationalism from the perspective of teachers at CLC Sarawak, Malaysia. The research uses qualitative method with case study approach that focuses on factors that can foster nationalism of IMW’s children. Data collection obtained through observation techniques, in-depth interviews, and documentation. The results showed meaningful findings according to the conditions in the education system in CLC, as well as socio-cultural conditions that affect every activity in the border area. The first finding indicates that CLC has an important (central) role in fostering the nationalism of IMW’s children in border areas. The second finding shows the fact that teachers are still experiencing some problems in the field, such as; limited access to information and communication, teacher education background, school conditions, limited educational units, learning facilities, and family and social environments. The third finding emphasizes the importance of nationalism for teachers who devote themselves to teaching in border areas, because teachers have a crucial role in transferring knowledge, providing meaningful learning experiences, and fostering the nationalism of IMW’s children.
Research Capability: Early-Career Academics’ Perception of Doctoral Studies
Authors: Mydin Faridah , Surat Shahlan
Published: September 2021

The purpose of doctoral education is not only to produce a thesis but also to develop graduates who are highly competent in research, publications and the norms and values of being a researcher. Only a handful of studies have examined early-career academics’ perceptions of doing research at the doctoral level. This exploratory qualitative study sought to fill the gap and contribute to understanding of factors contributing to early career academics’ research capability development. Semi-structured interviews were used to explore in-depth the issues concerning research, publication, supervision, and networking among early career academics. The data were collected from 19 early-career academics in the first year of their career, who are attached with different universities and in different disciplines in Malaysia. The findings from the thematic analysis identified that supervision, individual’s participation in scholarly research activities, and institutional formal learning supported the development of the participants’ research capabilities. Although the PhD programme lay emphasis on independent learning, it should be seen as a process that occurs in phases; hence, the research courses offered and support from the supervisor are important to assist the transition to becoming an independent scholar. Based on the findings of the study, it is recommended that universities be more sensitive to the demands and expectations of academic career so that the PhD programmes offered do not merely focus on research but also develop the skills required of future academics at university.
Metasurface parameter optimization of Fano resonance based on a BP-PSO algorithm
Authors: Chen Ying , Ding Zhixin , Zhang Min , Zhou Jian , Li Meijie , Zhao Meng , Wang Jiankun
Published: September 2021

An all-dielectric metasurface is proposed, and the transmission spectrum is analyzed by numerical simulation. The Fano resonance line appears in the transmission spectrum. The mechanism of Fano resonance is analyzed based on multipole coupling theory. The mathematical model between structural parameters and spectral performance is established by the back propagation (BP) neural network. Then, the genetic algorithm, sparrow search algorithm, and particle swarm optimization (PSO) algorithms are used to find the structural parameters corresponding to the optimal performance. The result shows that the quality factor is increased by three times, reaching 3805, and the modulation depth is close to 100% after PSO optimization. Our study provides a new method for the design of metasurfaces and parameter optimization of optical micro-nano structures.
Few pulses femtosecond laser exposure for high efficiency 3D glass micromachining
Authors: Casamenti Enrico , Pollonghini Sacha , Bellouard Yves
Published: September 2021

Advanced three-dimensional manufacturing techniques are triggering new paradigms in the way we design and produce sophisticated parts on demand. Yet, to fully unravel its potential, a few limitations have to be overcome, one of them being the realization of high-aspect-ratio structures of arbitrary shapes at sufficiently high resolution and scalability. Among the most promising advanced manufacturing methods that emerged recently is the use of optical non-linear absorption effects, and in particular, its implementation in 3D printing of glass based on femtosecond laser exposure combined with chemical etching. Here, we optimize both laser and chemical processes to achieve unprecedented aspect ratio levels. We further show how the formation of pre-cursor laser-induced defects in the glass matrix plays a key role in etching selectivity. In particular, we demonstrate that there is an optimal energy dose, an order of magnitude smaller than the currently used ones, yielding to higher process efficiency and lower processing time. This research, in addition to a conspicuous technological advancement, unravels key mechanisms in laser-matter interactions essential in chemically-based glass manufacturing and offers an environmentally-friendly pathway through the use of less-dangerous etchants, replacing the commonly used hydrofluoric acid.
Roadmap for the use of base editors to decipher drug mechanism of action
Authors: Aparicio-Prat Estel , Yan Dong , Mariotti Marco , Bassik Michael , Hess Gaelen , Fortin Jean-Philippe , Weston Andrea , Xi Hualin S. , Stanton Robert
Published: September 2021

CRISPR base editors are powerful tools for large-scale mutagenesis studies. This kind of approach can elucidate the mechanism of action of compounds, a key process in drug discovery. Here, we explore the utility of base editors in an early drug discovery context focusing on G-protein coupled receptors. A pooled mutagenesis screening framework was set up based on a modified version of the CRISPR-X base editor system. We determine optimized experimental conditions for mutagenesis where sgRNAs are delivered by cell transfection or viral infection over extended time periods (>14 days), resulting in high mutagenesis produced in a short region located at -4/+8 nucleotides with respect to the sgRNA match. The β2 Adrenergic Receptor (B2AR) was targeted in this way employing a 6xCRE-mCherry reporter system to monitor its response to isoproterenol. The results of our screening indicate that residue 184 of B2AR is crucial for its activation. Based on our experience, we outline the crucial points to consider when designing and performing CRISPR-based pooled mutagenesis screening, including the typical technical hurdles encountered when studying compound pharmacology.
KLAUS WYRTKI AND THE MODERN ERA OF THE MARITIME CONTINENT OCEANOGRAPHY
Authors: Gordon Arnold
Published: September 2021

The December 2019 issue of Marine Research in Indonesia on "Oceanography of the Indonesian Seas" is dedicated to Klaus Wyrtki. In many ways, Klaus Wyrtki's contribution to the study of the Indonesian seas served as a smooth transition from the era of the great expeditions such as the Dutch Willebrord Snellius Expedition (1929-1930; see Wüst, 1964; van Aken, 2005) of the early and mid-20th century to the modern era.

In the NAGA Report (Wyrtki, 1961; also see Wyrtki, 2005), Klaus used existing ocean observations, supplemented with data he helped collect on the Indonesian research ship Samudera during his sojourn in Indonesia (1954-1957) as Head of the Institute of Marine Research in Jakarta to map out a broad view of the Southeast Asian waters (the waters of the Maritime Continent including the Indonesian seas). He presented the geography, the configuration of the seas and basins of the Southeast Asian waters, the surface circulation, and governing dynamics, including the tides and monsoonal driven seasonality, and the temperature/salinity surface layer patterns, as well as aspects of the subsurface stratification. The Plates 1-44 beautifully reveal the oceanographic condition of the Southeast Asian waters as resolved by the pre-1960 observations.

As Klaus Wyrtki says in the NAGA Report Preface: "It is hoped that workers in the region, whether in oceanography or other branches of science may find it a source of information and a stimulus to undertake further research in these waters" and "The scientific publications dealing with this region show not so much a lack of observations as a lack of an adequate attempt to synthesize these results to give a comprehensive description of the region." "I soon decided to devote most of my time during my three years’ stay in Indonesia to the preparation of a general description of the oceanography of these waters." He succeeded.
MANAGING SHIFTING FISHERIES RESOURCES
Authors: Ryan Charlotte , Rifai Husen , Feng Anne , O'Hara Nicole , Saawant Swapnil
Published: September 2021

The unprecedented rate of climate change and over-exploitation of resources has had a significant impact on ecosystems around the globe. In particular, the oceanic realm has encountered multiple changes to ecosystem conditions, food web dynamics and habitat constructs. Many marine species have been driven to shift their geographical range in reaction to reaching their physiological limits causing severe metabolic stress. This includes key fishery targets, such as pelagic and carnivorous fish, that supply many nations with their primary or secondary protein source. The shift also spurs an array of political and economic consequences due to the need for fisheries to follow or target different fish stocks that are no longer in their exclusive economic zone or legal fishing waters. For this reason, and many other logistical and financial reasons, management strategies have struggled to maintain and sustain fish stocks around the globe. This paper will look at a Northeast Atlantic mackerel case study, compare and analyse the implications of shifting fish stocks, and illustrate difficulties related to managing the fisheries which target these stocks. Furthermore, we highlight the need for a combination of global strategies, and smaller-scale ecosystem approaches in fisheries management to be able to sufficiently sustain fisheries and thus future food security, during a time of climatic change.
Are they always bad? Assessing benefits of non-indigenous species in aquatic environment and their implications
Authors: Islami Muhammad Masrur
Published: September 2021

Non-indigenous species (NIS), non-native, or alien species are any organisms living and spreading outside their natural habitat. Many of NIS spread to a new environment accidentally, while some other species are intentionally introduced by humans to a new habitat in many different pathways, as follows: 1) release; 2) escape; 3) contaminant; 4) stowaway; 5) corridor; and 6) unaided. Threaten native biodiversity may be the most problematic impact of NIS. They can also disrupt food-web organizations and affect the ecosystem structures. Additionally, the problem is exacerbated by disagreements regarding whether or not NIS should be permitted for aquaculture production. The likelihood of NIS escaping, being released from aquaculture, and establishing in its native habitat poses a significant threat to the ecosystem and biodiversity. NIS also have positive impacts as ecosystem engineers which may increase the biodiversity of native communities. Other benefits of NIS include providing an alternative food source and supporting fisheries and aquaculture sectors. Understanding the introduction process and the impacts of NIS should be supported by effective policy frameworks and management approaches, including risk assessment, prevention and control, pathway and vector management, early detection and rapid response, eradication, and mitigation and restoration. Furthermore, the crucial efforts would be raising public awareness, improving scientific research, and developing strategy regarding biosecurity issues as consequences of the emergence of interactions complexity among NIS and other global ecological change drivers.
Aggregates in aquatic ecosystems and implications for aquacultures
Authors: Alfiansah Yustian Rovi
Published: September 2021

Agglomerations of suspended particulate matter serve various roles in aquatic ecosystems. They participate in nutrient and energy fluxes and are involved in important food web processes. While comprehensive studies on aggregates are available from natural freshwater and marine ecosystems, little is known about the roles of aggregates in aquacultures, particularly in shrimp pond farming. As particle-rich systems, shrimp ponds and marine aquaculture (mariculture) areas constitute interesting objects for aggregate studies, particularly as a source of natural feed, particle fluxes, microbial communities, including pathogenic bacteria, and possible vector of disease widespread. The aims of this review are i) to compile the current knowledge on the role of aggregates in aquatic ecosystems, particularly in aquaculture areas covering advantages and negative side effects of aggregates in aquacultures, ii) to explore the role of aggregates in disease ecology, and iii) perspective of aquaculture management in the context of aggregate utilization and management. Since Southeast Asia, especially Indonesia, is among the most important regions for aquaculture activities, this review focuses on Indonesian aquacultures. Although aquacultures produce important amounts of aggregates, including its associated microbial communities, they are rarely investigated in Indonesian aquacultures, particularly in shrimp pond farming. In contrast, most of the studies focused on bacterial cultivation and utilization of isolates for aquacultures. Thus, understanding the ecological roles of aggregates in aquacultures may support the improvement of aquaculture management and yields.
A Survey of Psychological Symptoms One Month Post Discharge in Patients Infected with COVID 19
Authors: Joopaka Ajay Kumar , Umashankar Molanguri , Srilakshmi Pingali , Telkapalli Pradeep Sharma , Banoth Chinni Krishna , N.M. Laxmi Achyutha , Kante Sailakshmi
Published: September 2021

BACKGROUND Corona virus disease or the (COVID 19) has caused mental health problems in the general population, in people infected and hospitalised for the disease and in patients who have recovered from the disease physically but continue to suffer from lingering mental health problems. Studies have shown stress, depression, and anxiety in one third of the survivors. Similarly post-traumatic stress disorder has been reported to be around 13 % in the survivors of COVID 19. In this study, we wanted to assess the psychological symptoms in the survivors of Covid 19 patients, one month post discharge and also assess various factors associated with the same. METHODS A cross sectional telephonic survey of the patients one month following discharge was done to understand the psychological problems. Sociodemographic data was recorded on a semi structured proforma, whereas psychological distress was recorded on patient health questionnaire - 4 (PHQ - 4) and the post-traumatic stress disorder (PTSD) was screened for by the impact of event scale revised (IES - R). RESULTS Of the 200 patients evaluated, 46.8 % scored above 20 on the impact of event scale which was considered to be a positive screen for post-traumatic stress disorder. Moderate psychological distress was reported by 10.5 % and severe by 7.5 % as measured by PHQ - 4. Being married, having other family members effected by the infection and deaths in the family were some of the factors that were significantly associated with psychological distress and symptoms of post-traumatic stress disorder. CONCLUSIONS Continued mental health support needs to be extended to members who are considered to have recovered and discharged from the hospital following the COVID 19 infection. KEY WORDS COVID 19, Psychological Symptoms, Post-Traumatic Stress Disorder