bluuebunny/crossref_metadata_2025 huggingface dataset:
Two new synonyms of Haploperla valentinae Stark & Sivec, 2009 and supplementary redescription of H. tuanjiena Chen & Du, 2016 from western China
Authors: REHMAN ABDUR , HUO QING-BO , DU YU-ZHOU
Published: April 2022

We examined specimens of the Haploperla Navás, 1934 from Sichuan and Qinghai provinces, China. Two new synonyms of Haploperla valentinae Stark & Sivec, 2009 are established: Haploperla triangulata Chen & Du, 2016 syn. nov. and Haploperla datongensis Chen & Du, 2016 syn. nov. We redescribed H. valentinae from China with new color images to facilitate the identification. In addition, we also provide supplementary descriptions and contemporary color images of H. tuanjiena Du & Chen, 2016.
COMMENTARY – THE BOSNIAN TINDERBOX
Authors: Dijkstra Gerrit S.A. , Raadschelders Jos C.N.
Published: April 2022

Given the pace of contemporary events, this brief commentary is intended as an addendum and recent update to our original research article that is also published in this issue of World Affairs(vol. 185, no. 2) entitled “The High Representative in Bosnia‐Herzegovina: The Unusual Institutional Arrangement of a Non‐Authoritarian, yet Controlled, Democracy” (see Dijkstra and Raadschelders 2022). We focus here on Russia's role in Bosnia and raise some tentative questions that are likely to remain extremely important for world affairs in the Balkans and beyond over the coming months. This commentary was submitted to World AffairsJournal some days before the Russian invasion of Ukraine on February 24, 2022. Given the extreme unpredictability of the situation regarding Ukraine and Russia, we elected not to provide substantive updates since late February 2022.
Association of Ear Anomalies and Hearing Loss Among Children With 22q11.2 Deletion Syndrome
Authors: Wu Shannon S. , Mahomva Chengetai , Sawaf Tuleen , Reinshagen Katherine L. , Karakasis Christopher , Cohen Michael S. , Hadford Stephen , Anne Samantha
Published: April 2022

Objective

To identify inner and middle ear anomalies in children with 22q11.2 deletion syndrome (22q11DS) and determine associations with hearing thresholds.

Study Design

Retrospective study.

Setting

Two tertiary care academic centers.

Methods

Children presenting with 22q11DS between 2010 and 2020 were included. Temporal bone imaging with computed tomography or magnetic resonance imaging was reviewed by 2 neuroradiologists.

Results

Twenty‐two patients (12 female, 10 male) were identified. Forty‐four ears were evaluated on imaging. There were 15 (34%) ears with abnormal semicircular canals, 14 (32%) with abnormal vestibules, 8 (18%) with abnormal ossicles, 6 (14%) with enlarged vestibular aqueducts, 4 (9.1%) with abnormal facial nerve canals, and 4 (9.1%) with cochlear anomalies. There were 25 ears with imaging and audiometric data. The median pure tone average (PTA) for ears with any structural abnormality was 41.0 dB, as compared with 28.5 dB for ears without any structural abnormality (P = .21). Of 23 ears with normal imaging, 6 (26%) had hearing loss in comparison with 13 (62%) of 21 ears with abnormalities (P = .02). Total number of anomalies per ear was positively correlated with PTA (Pearson correlation coefficient, R = 0.479, P = .01). PTA was significantly higher in patients with facial nerve canal anomalies (P = .002), vestibular aqueduct anomalies (P = .05), and vestibule anomalies (P = .02).

Conclusions

Semicircular canal, ossicular, vestibular aqueduct, and vestibular anomalies were detected in children with 22q11DS, especially in the setting of hearing loss. Careful evaluation of anatomic anomalies is needed prior to surgical intervention in these patients.
Disruption of dNTP homeostasis by ribonucleotide reductase hyperactivation overcomes AML differentiation blockade
Authors: Wang Hanying , He Xin , Zhang Lei , Dong Haojie , Huang Feiteng , Xian Jie , Li Min , Chen Wei , Lu Xiyuan , Pathak Khyatiben V. , Huang Wenfeng , Li Zheng , Zhang Lianjun , Nguyen Le Xuan Truong , Yang Lu , Feng Lifeng , Gordon David J. , Zhang Jing , Pirrotte Patrick , Chen Chun-Wei , Salhotra Amandeep , Kuo Ya-Huei , Horne David , Marcucci Guido , Sykes David B. , Tiziani Stefano , Jin Hongchuan , Wang Xian , Li Ling
Published: April 2022

Differentiation blockade is a hallmark of acute myeloid leukemia (AML). A strategy to overcome such a blockade is a promising approach against the disease. The lack of understanding of the underlying mechanisms hampers development of such strategies. Dysregulated ribonucleotide reductase (RNR) is considered a druggable target in proliferative cancers susceptible to deoxynucleoside triphosphate (dNTP) depletion. Herein, we report an unanticipated discovery that hyperactivating RNR enables differentiation and decreases leukemia cell growth. We integrate pharmacogenomics and metabolomics analyses to identify that pharmacologically (eg, nelarabine) or genetically upregulating RNR subunit M2 (RRM2) creates a dNTP pool imbalance and overcomes differentiation arrest. Moreover, R-loop–mediated DNA replication stress signaling is responsible for RRM2 activation by nelarabine treatment. Further aggravating dNTP imbalance by depleting the dNTP hydrolase SAM domain and HD domain-containing protein 1 (SAMHD1) enhances ablation of leukemia stem cells by RRM2 hyperactivation. Mechanistically, excessive activation of extracellular signal-regulated kinase (ERK) signaling downstream of the imbalance contributes to cellular outcomes of RNR hyperactivation. A CRISPR screen identifies a synthetic lethal interaction between loss of DUSP6, an ERK-negative regulator, and nelarabine treatment. These data demonstrate that dNTP homeostasis governs leukemia maintenance, and a combination of DUSP inhibition and nelarabine represents a therapeutic strategy.
H3K9me2 regulation of BDNF expression via G9a partakes in the progression of heart failure
Authors: Yan Fang , Chen Ziying , Cui Wei
Published: April 2022

Background

Heart disease is a major cause of mortality in developed countries. The associated pathology is mainly characterized by the loss of cardiomyocytes that contributes to heart failure (HF). This study aims to investigate the mechanism of euchromatic histone lysine methyltransferase 2 (EHMT2, also term G9a) in HF in rats.

Methods

Differentially expressed mRNAs in HF were screened using GEO database. Sera from subjects with or without HF were collected, and PCR was performed to detect the G9a expression. G9a was downregulated in cardiomyocytes exposed to oxygen–glucose deprivation (OGD), followed by CCK8, flow cytometry, colorimetric method, and western blot assays. Established HF rats were delivered with lentiviral vectors carrying sh-G9a, and TTC staining, HE staining, TUNEL, ELISA, and western blot were performed. The regulation of G9a on the downstream target BDNF was investigated by RT-qPCR, Western blot, and ChIP-qPCR. Finally, rescue experiments were carried out to substantiate the effect of G9a on cardiomyocyte apoptosis and injury via the BDNF/TrkB axis.

Results

G9a was overexpressed, whereas BDNF was downregulated in HF. Knockdown of G9a inhibited apoptosis and injury in OGD-treated cardiomyocytes and attenuated the extent of HF and myocardial injury in rats. Silencing of G9a promoted BDNF transcription by repressing H3K9me2 modification of the BDNF promoter. Further depletion of BDNF partially reversed the effect of sh-G9a in alleviating cardiomyocyte apoptosis and injury by inhibiting the TrkB signaling pathway.

Conclusion

G9a inhibits BDNF expression through H3K9me2 modification, thereby impairing the TrkB signaling pathway and exacerbating the development of HF.
ABCD approach at the #7119 center, telephone triage system in Tokyo, Japan; a retrospective cohort study
Authors: Sakurai Atsushi , Ohta Sachiko , Oda Jun , Muguruma Takashi , Abe Takeru , Morimura Naoto
Published: April 2022

Background

The algorithm and protocol of the #7119 telephone triage in Tokyo, Japan, had been originally established and consists of three steps. In this study, we investigated the outcome of patients treated with physiological abnormality (ABCD approach: A, airway; B, breathing; C, circulation, and D, dysfunction of central nervous system) in step 2 during the #7119 telephone triage and clarified the meaning of evaluation of this approach.

Methods

We retrospectively reviewed data from the Tokyo Fire Department from January 2016 to December 2017. Almost all the patients triaged using the ABCD approach were transferred to the hospital by ambulance and assigned severity by a physician. We divided patients into groups with combinations of 15 patterns including A, B, C, D, AB, AC, AD, BC, BD, CD, ABC, ABD, ACD, BCD, and ABCD. We compared the proportion of severe cases in each group using a Fisher's exact test, followed by residual analysis.

Results

We analyzed 13,793 cases triaged using the ABCD approach. In this analysis, 31% of total cases were assessed as severe cases. Groupwise analysis showed that the proportion of severe cases was significantly higher in the AD, BC, CD, ABD, and ABCD groups, while it was significantly less in the C and AB groups than in the total cases.

Conclusion

At the #7119 telephone triage, we can pick up the severe cases by the ABCD approach. This may contribute to the prompt transportation of severe patients to hospitals by dispatching ambulance cars using the #7119 telephone triage methods.
A longitudinal cohort study of gestational diabetes mellitus and perinatal depression
Authors: Li Haiyan , Yu Xiayan , Qiang Wenjing , Lu Mengjuan , Jiang Minmin , Hou Yanyan , Gu Yue , Tao Fangbiao , Zhu Beibei
Published: April 2022

Background

The association between gestational diabetes mellitus (GDM) and perinatal depression (PND) remains controversial. Our study aimed to comprehensively assess this association in a longitudinal cohort study with repeated measurements of depression.

Methods

Our cohort study was nested in a pilot study of an implementation study aiming to screen and manage perinatal depression within the primary health system in China. Women were recruited in the first trimester from May–September 2019 and followed four times up to 1 year postpartum. Data on sociodemographic characteristics and depression were collected using self-developed questionnaires incorporating the Edinburgh Postnatal Depression Scale (EPDS). Oral glucose tolerance test at 24 ~ 28 weeks and fasting plasma glucose (FPG) data were extracted from medical records. Depression throughout the whole period was divided into different trajectories. Associations of GDM with PND at different time periods and PND of different trajectories were determined by logistic regression. The path of association between blood glucose and depression over time was estimated with an autoregressive cross-lagged model.

Results

In total, 1043 women were included in this analysis and 313 (30.0%) were diagnosed with GDM. The prevalence of depression in the first, second, and third trimesters and postpartum period were 17.2, 6.9, 6.8 and 9.0%, respectively. GDM was neither significantly associated with PND at any time point nor with any specific trajectory of depression. Except for autoregressive paths, no cross-lagged path of FPG and scores of EPDS was significant.

Conclusions

Our study indicates no association between GDM/blood glucose and PND.
Pesticides and environmental injustice in the USA: root causes, current regulatory reinforcement and a path forward
Authors: Donley Nathan , Bullard Robert D. , Economos Jeannie , Figueroa Iris , Lee Jovita , Liebman Amy K. , Martinez Dominica Navarro , Shafiei Fatemeh
Published: April 2022

Many environmental pollutants are known to have disproportionate effects on Black, Indigenous and People of Color (BIPOC) as well as communities of low-income and wealth. The reasons for these disproportionate effects are complex and involve hundreds of years of systematic oppression kept in place through structural racism and classism in the USA. Here we analyze the available literature and existing datasets to determine the extent to which disparities in exposure and harm exist for one of the most widespread pollutants in the world – pesticides. Our objective was to identify and discuss not only the historical injustices that have led to these disparities, but also the current laws, policies and regulatory practices that perpetuate them to this day with the ultimate goal of proposing achievable solutions. Disparities in exposures and harms from pesticides are widespread, impacting BIPOC and low-income communities in both rural and urban settings and occurring throughout the entire lifecycle of the pesticide from production to end-use. These disparities are being perpetuated by current laws and regulations through 1) a pesticide safety double standard, 2) inadequate worker protections, and 3) export of dangerous pesticides to developing countries. Racial, ethnic and income disparities are also maintained through policies and regulatory practices that 4) fail to implement environmental justice Executive Orders, 5) fail to account for unintended pesticide use or provide adequate training and support, 6) fail to effectively monitor and follow-up with vulnerable communities post-approval, and 7) fail to implement essential protections for children. Here we’ve identified federal laws, regulations, policies, and practices that allow for disparities in pesticide exposure and harm to remain entrenched in everyday life for environmental justice communities. This is not simply a pesticides issue, but a broader public health and civil rights issue. The true fix is to shift the USA to a more just system based on the Precautionary Principle to prevent harmful pollution exposure to everyone, regardless of skin tone or income. However, there are actions that can be taken within our existing framework in the short term to make our unjust regulatory system work better for everyone.
Alcohol use disorder and its association with quality of life and mortality in Chinese male adults: a population-based cohort study
Authors: Lu Jiapeng , Yang Yang , Cui Jianlan , Xu Wei , Wu Chaoqun , Li Jing , Li Xi
Published: April 2022

Aims

We aimed to demonstrate the distribution of alcohol use disorder (AUD) in China and assess its association with quality of life and mortality.

Methods

We studied 367 120 men aged 35–75 years from 31 provinces in the China Patient-Centered Evaluative Assessment of Cardiac Events (PEACE) Million Persons Project. At baseline, AUD was assessed by alcohol use disorders identification test score, and EQ-5D-3L questionnaire was used to measure the quality of life. Mortality data was collected via National Mortality Surveillance System and Vital Registration. Mixed models were fitted to assess the associations of AUD with quality of life, and Cox proportional hazard models were fitted for the associations with all-cause and cause-specific mortality.

Results

We identified 39 163 men with AUD, which accounted for 10.7% of male participants and 25.8% of male drinkers. In the multivariable analysis, male drinkers who were aged 45–54 years, with higher education level, currently smoking, obese, with diagnosed hypertension, and without diagnosed cardiovascular diseases had higher rates of AUD. Male drinkers with AUD were less likely to have optimal QOL compared with those without AUD (OR: 0.63, 95% CI: 0.61–0.65, P < 0.001). Moreover, among male drinkers, AUD was prospectively associated with a 20% higher risk for all-cause mortality and a 30% higher risk for mortality from cancer.

Conclusions

In China one fourth of men who drank alcohol had AUD, which was associated with lower QOL and higher risk of all-cause mortality. National policies or strategies are urgently needed to control alcohol-related harms.
Coverage, inequity and predictors of hepatitis B birth vaccination in Myanmar from 2011–2016: results from a national survey
Authors: Anderson August C. T. , Richards Adam , Delucchi Kevin , Khalili Mandana
Published: April 2022

Background

Hepatitis B virus birth dose (HepB-BD) vaccination is recommended to reduce mother to infant transmission. We evaluated the HepB-BD status of women who gave birth between 2011 and 2016 (N = 3,583) using the 2015–2016 Myanmar Demographic and Health Survey.

Methods

Frequency distributions of HepB-BD vaccination across maternal and health system factors, concentration indices, and logistic regression models were used to estimate coverage, inequity, and factors associated with vaccination.

Results

The majority of participants were younger than 30 years of age, lived in rural areas, and were multiparous. Almost all received antenatal care (ANC), but only 43% received recommended ANC services, and 60% gave birth at home. The overall HepB-BD coverage rate was 26%. Vaccination coverage was higher in urban areas and was inequitably concentrated among children of more educated and wealthier women. HepB-BD coverage was also positively associated with receipt of ANC at non-governmental facilities, and delivery at a facility, skilled provider at birth and Cesarean delivery. After adjusting for sociodemographic and health system factors, receipt of the HepB-BD was positively associated with weekly media exposure, receipt of recommended ANC, and Cesarean delivery, and inversely associated with home delivery.

Conclusions

Both socioeconomic and health systems factors influenced suboptimal and inequitable vaccination coverage. Improved access to quality ANC and delivery services may increase HepB-BD coverage although targeted approaches to reach home births are likely required to achieve national goals.
PEGR: a flexible management platform for reproducible epigenomic and genomic research
Authors: Shao Danying , Kellogg Gretta D. , Nematbakhsh Ali , Kuntala Prashant K. , Mahony Shaun , Pugh B. Franklin , Lai William K. M.
Published: April 2022

Reproducibility is a significant challenge in (epi)genomic research due to the complexity of experiments composed of traditional biochemistry and informatics. Recent advances have exacerbated this as high-throughput sequencing data is generated at an unprecedented pace. Here, we report the development of a Platform for Epi-Genomic Research (PEGR), a web-based project management platform that tracks and quality controls experiments from conception to publication-ready figures, compatible with multiple assays and bioinformatic pipelines. It supports rigor and reproducibility for biochemists working at the bench, while fully supporting reproducibility and reliability for bioinformaticians through integration with the Galaxy platform.
Thyroid Hormone Abuse in Elite Sports: The Regulatory Challenge
Authors: Gild Matti L , Stuart Mark , Clifton-Bligh Roderick J , Kinahan Audrey , Handelsman David J
Published: April 2022

Abuse of androgens and erythropoietin has led to hormones being the most effective and frequent class of ergogenic substances prohibited in elite sports by the World Anti-Doping Agency (WADA). At present, thyroid hormone (TH) abuse is not prohibited, but its prevalence among elite athletes and nonprohibited status remains controversial. A corollary of prohibiting hormones for elite sports is that endocrinologists must be aware of a professional athlete’s risk of disqualification for using prohibited hormones and/or to certify Therapeutic Use Exemptions, which allow individual athletes to use prohibited substances for valid medical indications. This narrative review considers the status of TH within the framework of the WADA Code criteria for prohibiting substances, which requires meeting 2 of 3 equally important criteria of potential performance enhancement, harmfulness to health, and violation of the spirit of sport. In considering the valid clinical uses of TH, the prevalence of TH use among young adults, the reason why some athletes seek to use TH, and the pathophysiology of sought-after and adverse effects of TH abuse, together with the challenges of detecting TH abuse, it can be concluded that, on the basis of present data, prohibition of TH in elite sport is neither justified nor feasible.
Λουκιανού Ἀληθῆ διηγήματα
Authors: Κανάλη Ανθή
Published: April 2022

Τα Ἀληθῆ διηγήματα του Λουκιανού είναι ένα καινοφανές δημιούργημα της δεύτερης σοφιστικής, που διαφεύγει εντέχνως την ειδολογική του ένταξη. Ο φανταστικός κόσμος που πλάθει ο Λουκιανός, με τα εξωπραγματικά όντα που τον απαρτίζουν, αποτελεί, τηρουμένων των αναλογιών, μια προτύπωση των μεταγενέστερων science fiction μυθιστορημάτων της δυτικής λογοτεχνίας. Έργο όψιμο, διαπνέεται από την «αγωνία της επίδρασης» των συγγραφέων της μετακλασικής εποχής, και στο πλαίσιο αυτό αντανακλά άλλοτε ρητά και άλλοτε υπόρρητα την ίδια τη διαδικασία συγγραφής, της πρόσληψης, και ανατέμνει το ζήτημα της συγγραφικής αυθεντίας. Η παρούσα διατριβή ερμηνεύει το ταξίδι στην ἑτέραν γῆν ως όχημα στοχασμού πάνω στη λογοτεχνική δημιουργία, στη σχέση μυθοπλασίας-πραγματικότητας, στην υπέρβαση των ορίων του λογοτεχνικού κανόνα. Ανιχνεύονται οι αφηγηματικές τεχνικές, που υποδαυλίζουν τη σχέση ἀληθείας-ψεύδους, και συμβάλλουν στην ανάδειξη της μεταμυθοπλασίας. Η αποστασιοποίηση, η ανοικείωση, η εναλλαγή της εστίασης είναι τα μέσα αμφισβήτησης του οικείου και γνώριμου, τα εργαλεία θραύσης του τρόπου με τον οποίο κατανοούμε τον κόσμο. Κι αν ο συγγραφέας ομνύει με κάθε τρόπο στο caveat lector, είναι γιατί το έργο δεν αποτελεί ένα αποθετήριο γνώσης που διαμηνύει τη βαθύτερη αλήθεια του συγγραφέα, αλλά ένα ολισθηρό πεδίο ακατάπαυστου στοχασμού.
Η ίδρυση και τα πρώτα χρόνια της Σχολής Φυσικών και Μαθηματικών Επιστημών του Πανεπιστημίου Αθηνών (τέλη 19ου αι. - 1922)
Authors: Σιγούντου Βασιλική
Published: April 2022

Η παρούσα διατριβή διατυπώνει τη θέση ότι δύο καίρια ζητήματα δέσποσαν στον χώρο των πανεπιστημιακών σπουδών στις φυσικές και μαθηματικές επιστήμες από τα τέλη του 19ου αιώνα έως την έναρξη του μεσοπολέμου. Το πρώτο σχετιζόταν με το αίτημα το Πανεπιστήμιο Αθηνών να παρέχει μία εξειδικευμένη εκπαίδευση στις φυσικές επιστήμες, είχε επίκεντρο τις χημικές σπουδές και επαγγελία τη δημιουργία ενός επιστημονικού δυναμικού προσανατολισμένου στον παραγωγικό τομέα της οικονομίας. Το δεύτερο συνδεόταν με τη συζήτηση για τις αποστολές του Πανεπιστημίου και συγκεκριμένα με την προβολή της επιδίωξης να ενισχυθεί η ερευνητική διάσταση στο έργο του, παράλληλα με την εκπαιδευτική αποστολή. Τα δύο ζητήματα συνδυαστικά ανέδειξαν ένα μείζον τρίτο: την εξεύρεση των πόρων που θα εξασφάλιζαν μία ανάπτυξη σύστοιχη με τις νέες προτεραιότητες για την εκπαίδευση και την έρευνα. Υπό το πρίσμα αυτών των καίριων ζητημάτων η διατριβή εξετάζει την πορεία προς την ίδρυση της Φυσικομαθηματικής Σχολής και τα πρώτα χρόνια της αυτόνομης λειτουργίας της. Κύριοι άξονες της μελέτης είναι η συγκρότηση, αφενός, του καθηγητικού σώματος και, αφετέρου, του επιστημονικού προσωπικού των εργαστηρίων και των μουσείων το οποίο, στο εξεταζόμενο διάστημα, είχε λάβει κρίσιμο μέγεθος που ευνοούσε αλλαγές στο ακαδημαϊκό επάγγελμα. Ειδικότερα, η διατριβή διερευνά τις διεργασίες γύρω από την ίδρυση του Τμήματος Χημείας. Αναδεικνύει τις βαθύτερες χρονικές ρίζες του εγχειρήματος και ερμηνεύει την τελική ίδρυση του χημικού πτυχίου με βάση τη συνθήκη που όρισαν τρεις αλληλένδετες παράμετροι: οι επιρροές από την ευρωπαϊκή συζήτηση για την ανώτατη εκπαίδευση και οι τροπές της λόγω της βίωσης του πολέμου· οι εσωτερικές συνθήκες στην Ελλάδα και η επιδίωξη να διατυπωθεί ένα αφήγημα με οραματική προοπτική για τη χώρα· καθώς και σχέδια για τον ρόλο της Ελλάδας εντός μίας ευρύτερης κατανομής ισχύος στον γεωπολιτικό χάρτη.
Role of the settlement network in the formation of territorial communities in the Kolomyia district of the Ivano-Frankivsk oblast
Authors: Kostashchuk Ivan , Bilous Yurii , Verbishchuk Bohdan
Published: April 2022

This article examines the peculiarities of the settlement network of the established Kolomyia district (raion) of Ivano-Frankivsk oblast and its importance in the formation of territorial communities (hromada). We analyzed the peculiarities of the functioning of local settlement systems through the indicators of transport accessibility to the center of the community and administrative service centers, as well as the concentration coefficient of the population. We identified strengths and weaknesses, as well as threats and opportunities during the SWOT-analysis.
Współczesne wariacje na temat eposu „Ædnan” Linnei Axelsson
Authors: Wasilewska-Chmura Magdalena
Published: April 2022

Artykuł problematyzuje gatunek eposu na przykładzie jego współczesnej realizacji w poemacie Linnei Axelsson Ædnan (2018) o losach społeczności szwedzkich Saamów. Jego głównym założeniem jest, że wbrew tezie Bachtina epos nie jest gatunkiem spetryfikowanym i zamkniętym, lecz może zostać zredefiniowany, by wyrażać problemy współczesności. Analiza rozpoczyna się od wskazania cech gatunkowych eposu, które autorka w swoim dziele podważa. Są to: dykcja liryczna zamiast struktury narracyjnej i pośrednictwa narratora, wprowadzenie czasu historycznego w miejsce nieokreślonej przeszłości mitycznej oraz wyeksponowanie kobiecych bohaterek reprezentujących uciśnioną mniejszość w miejsce herosa o nadnaturalnych przymiotach. Funkcje tych rozwiązań w utworze rozpatrywane są przez pryzmat teorii kulturowych: postkolonialnych, feministycznych i genderowych. Pozwala to uchwycić specyfikę wywrotowego pisania kobiecego podważającego patriarchalne wzorce kulturowe: autorytet narratora, męski podmiot i dominację genderowych norm męskości. Jednocześnie wyraźne są cechy nawiązujące do poetyki eposu: mitologizacja sił natury, wspólnotowy wymiar osobistego doświadczenia oraz rola pamięci w tworzeniu tożsamości. W tym świetle utwór można odczytywać jako subwersywny dialog z tradycją eposu, gdzie dawne dążenie do władzy zastępuje apoteoza kulturowo deprecjonowanej Inności.
Erwin Kruk jako czytelnik
Authors: Chojnowski Zbigniew
Published: April 2022

Czytanie stanowiło dla Erwina Kruka (1941–2017) jedną z podstawowych form zarówno egzystencji, jak i uczestniczenia w życiu społecznym. W twórczości i wypowiedziach pisarza akt czytania jest przedmiotem refleksji. Kruk uważał, że czytając, „porządkujemy nasz świat” i budujemy własną tożsamość. Z powagą traktował słowo, co wynikało z luteranizmu, które ukształtowało Kruka w pierwszym okresie życia. Zamiłowanie do czytania tekstów autorów wywodzących się z Prus Wschodnich dyktowała Krukowi potrzeba odzyskania pamięci o swojej mazurskiej genealogii. Pisarz czuł się zobowiązany do śledzenia dawnej i współczesnej literatury z Warmii i Mazur, toteż uprawiał towarzyszącą jej krytykę literacką. Twierdził, że ambitne czytanie jest sposobem przeciwstawiania się prowincjonalizacji ośrodków kultury spoza centrum. Z przedstawionej rekonstrukcji listy lektur Erwina Kruka i jej sproblematyzowania wynika, że pisarz w całym swoim twórczym życiu realizował własną strategię czytania. Według Kruka jest to rodzaj pracy na rzecz podtrzymania ciągłości kulturowej tak zamieszkiwanego regionu, jak i innych kręgów wspólnoty ludzkiej.
Styl kuszenia Gustave’a Flauberta w „dziele jego życia”. Kwestia warunkowania
Authors: Garlej Beata
Published: April 2022

W artykule omówiono kwestię warunkowania stylu kuszenia właściwą dla ostatniej, trzeciej wersji Kuszenia świętego Antoniego Gustave’a Flauberta. Uwypuklając inspirację francuskiego pisarza tą postacią – inspirację zrodzoną już w dzieciństwie i utrwaloną wskutek zetknięcia się z dwoma artefaktami: obrazem Bruegla i ryciną Callota – tezę o „smutnej grotesce”, będącej jakościowym rezerwuarem „mówienia obrazami”, uznano za wyznacznik stylu kuszenia dzieła Flauberta. Dalsze rozważania oparto na tym, co jest przez co warunkowane, mianowicie: czy „smutną groteskę” można uznać za źródło stylu kuszenia, czy może jest ona wyłącznie jego skutkiem, czy jakość estetyczna funduje rodzaj stylu, czy może – na odwrót – to styl, jego konkretny rodzaj, wyzwala mechanizm jakościowej kategoryzacji? To główne rozważane problemy, dla których punktem odniesienia uczyniono refleksję Marii Gołaszewskiej (fenomen „kuszenia”) oraz Hermanna Pongsa (obrazowy styl). Wniosek, skądinąd paradoksalny w brzmieniu, uzgadniający bowiem to, że jakość estetyczna „smutnej groteski” może fundować określony rodzaj stylu, a jednocześnie, że styl kuszenia jest źródłem jakościowej kategoryzacji utworu, stanowi zwieńczenie prezentowanej myśli.
Etnografía digital del ciberactivismo político-social. Caso: elecciones generales españolas de 2019.
Authors: Flores-Vivar Jesús Miguel , Zaharía Ana María
Published: April 2022

El artículo analiza la inclusión de la antropología y etnografía digital en el estudio de la audiencia online que condiciona la ciberpolítica con el uso de las redes sociales en Internet. Desde hace algunos años, el ciberactivismo político de usuarios, realizado a través de los medios sociales, juega un papel importante en el fortalecimiento o respaldo de movimientos, partidos y líderes políticos, influyendo directamente en los resultados de los diversos comicios electorales en diferentes partes del mundo. Para entender este fenómeno es importante tener en cuenta las disciplinas mencionadas las mismas que constituyen paradigmas en la eclosión de los nuevos movimientos políticos en red y que aplicadas a las redes sociales configuran un coctel de estudio cada vez más necesario. Para el presente trabajo se realiza una revisión bibliográfica de la descripción y características fundamentales de la antropología y etnografía digital y se han tomado como referencia las páginas web de los principales medios sociales (Facebook, Twitter e Instagram) de partidos y líderes políticos en las elecciones de 2019 en España. El resultado obtenido sugiere un uso cada vez más especializado de las técnicas etnográficas y antropológicas en el estudio las redes sociales en ámbitos políticos o sociales, y, por consiguiente, su uso en el estudio de audiencias de los medios en Internet.
Frames del final del terrorismo de ETA. Análisis argumentativo de cuatro editoriales españoles (4 de mayo de 2018).
Authors: Jiménez-Yáñez Ricardo-María
Published: April 2022

En este estudio se pretende explorar la base ideológica y las estrategias argumentativas desplegadas en los editoriales de cuatro periódicos españoles (El Mundo, El País, La Vanguardia y El Periódico), del 4 mayo 2018, fecha de la publicación de la noticia del fin de la banda terrorista ETA. El análisis discursivo y argumentativo de estos editoriales se basa en un método híbrido -al que se le han incorporado nuevas categorías en este estudioresultado de la combinación de algunos principios del Análisis del Discurso y de la Lingüística del Texto, así como del Framing. En un nivel macro-estructural se explora la progresión argumentativa de texto (Amossy, 2006; 2009) y las metáforas conceptuales, y en otro nivel micro-estructural se analizan ciertos aspectos de la cohesión textual y de la argumentación, además de los frames. Como consecuencia de este análisis, se descubre la función destacada del «relato» en los editoriales de El Mundo y El País, el papel de las víctimas en el conjunto de los textos periodísticos estudiados, e incluso un posicionamiento diferente ante los presos etarras. Mientras que El Mundo y El País pretenden desarmar las mentiras de ETA, buscando conservar la memoria de la verdad de lo ocurrido, en el editorial de La Vanguardia se legitiman, veladamente, las pretensiones del grupo terrorista, e incluso queda desdibujada en el texto de El Periódico la crítica al relato de los terroristas por querer darles voz a todos los actores. Las estrategias argumentativas, los elementos de frame y las metáforas conceptuales del dominio espectáculo (El Mundo y El País) y del dominio guerra (La Vanguardia y El Periódico) trasladan el estilo decidido de El Mundo, el tono contundente de El País, y la moderación de La Vanguardia y de El Periódico.
The impact of an immuno-oncology service at a regional cancer centre based in the north west of the UK
Authors: Guinan Trudy-Jane , Garbutt Nick , Olsson-Brown Anna
Published: April 2022

This article discusses the implementation and development of a centralised immuno-oncology service. As the indications and licensing of oncological immune checkpoint inhibitors (ICIs) expanded rapidly, they brought with them increasing challenges. The article evaluates the impact of an immuno-oncology service, focusing on the following areas: admission rates due to immune-related adverse events (irAEs), number of bed days occupied due to immunotherapy toxicity and the incidence of Grade 3 and 4 (severe and life-threatening) irAEs. The article will also give an overview of patients requiring acute and subsequent management of toxicity as a percentage of the overall patients commenced on immunotherapy. The ultimate aim of the article is to highlight the importance of toxicity management and the overall benefits of a immuno-oncology service. The article will also discuss the impact of COVID-19 on the immuno-oncology service, highlighting the ways in which the team has adapted to the current environment to ensure high standards of patient care have been maintained.
Entrevista com Monique Prada: Negar a condição de trabalho do trabalho sexual é sobre não enxergar essa realidade ou não analisar a fundo a sociedade em que se vive.
Authors: Schaedler Martina da Silva , Didio Nicole Sudbrack
Published: April 2022

Entrevista com Monique Prada: Negar a condição de trabalho do trabalho sexual é sobre não enxergar essa realidade ou não analisar a fundo a sociedade em que se vive.
A dialética do instante na poesia de Cecília Meireles
Authors: Moreira Idmar Boaventura
Published: April 2022

No segundo poema do livro Viagem, publicado em 1939, naquele que viria a ser o mais conhecido dos seus poemas, “Motivo” – mais que um poema, uma poética  –, Cecília Meireles afirma a motivação de seu canto, mostra a distância entre o eu literário do poeta e o eu biográfico do autor e aponta, num movimento muito barroco, as tensões que perseguiria em toda sua obra poética, a partir de uma relação dialética entre o claro e o escuro, o provisório e o permanente, o material e o espiritual, a vida e a morte – tudo isso amalgamado na procura do instante, que Cecília Meireles perseguirá em toda sua obra. No último livro que publica, Solombra (1963), dirigindo-se a um enigmático e inalcançável “tu”, lamenta a insuficiência das palavras (“conchas secas”) e deseja ultrapassá-las, bem como a toda contingência (“libertar-me / das paredes, de tudo que aprisiona”), para, enfim, “ver eterno o instante”. O objetivo desse artigo, assim, é, a partir das reflexões de Gaston Bachelard (2010) acerca do instante poético, e das noções de imagem e ritmo, conforme apresentadas por Octavio Paz (2012) e Roberval Pereyr (2012), analisar alguns dos modos a partir dos quais uma dialética do instante se manifesta na poesia de Cecília Meireles.
Uma abordagem didático-metodológica do ensino de literatura de língua estrangeira: estudo das traduções de Jean-Pierre Rousseau dos poemas de Patativa do Assaré em língua francesa
Authors: Santana Ady Sá Teles
Published: April 2022

Esta proposta tem como objetivo uma análise sobre o Ensino de Literatura de Língua Estrangeira através das traduções em língua francesa dos poemas de Patativa do Assaré, um poeta brasileiro e nordestino. O interesse pela proposta pauta-se na experiência como docente da Universidade Estadual de Feira de Santana, instituição em que ensino as disciplinas de literatura francesa para os graduandos do curso de Francês. O objetivo principal desse estudo é averiguar que através das traduções dos textos populares brasileiros, o interesse pela literatura francesa dos estudantes de francês cresce, à medida que percebem a interlocução e o diálogo entre as duas culturas envolvidas no processo tradutório. A hipótese inicial pauta-se na noção de que estudando as traduções do poeta brasileiro, o discente terá curiosidade em conhecer o pensamento do "outro" enquanto estrangeiro que se interessou por sua cultura, por sua sociedade, visto que na sala de aula de literatura francesa o interesse pela leitura é parco, pois, no início das aulas os discentes recebem o material literário exigido pela disciplina e dificilmente eles leem. No intuito de compreender e explicar de forma didática, analítica e crítica a proposta de ensino de literatura de língua francesa através dos textos traduzidos do português para o francês, utiliza-se como suporte teórico as obras sobre tradução de Arrojo (1997), o conceito de Desconstrução de Derrida (1998/2005), assim também, autores de referência que são de fundamental relevância para análise da abordagem aqui apresentada, a exemplo de De Menezes (2013). Além disso, os poemas de Patativa do Assaré (1978) e as traduções desses poemas por Rousseau (2002) são o objeto principal dessa análise.
Desigualdades na Bahia em tempos de pandemia em Capitães da Areia de Jorge Amado
Authors: Silva de Miranda Maysa Maria
Published: April 2022

Este artigo põe em diálogo a questão da pandemia de covid-19 com a epidemia de varíola representada no romance Capitães da Areia da autoria de Jorge Amado e também no filme homônimo com a direção de Cecília Amado, neta do escritor baiano. O ponto de vista é o de considerar o panorama político brasileiro atual, caracterizado pela Necropolítica, termo criado por Achille Mbembe para denominar a expressão máxima da soberania política que reside no poder ditar quem pode viver e quem deve morrer. Tal panorama se apresenta também no romance e no filme, mas sobretudo contemporaneamente pela conduta do presidente do país que explicitamente nega, banaliza e dificulta as ações para debelar a epidemia, chamando a atenção de outros países. Essa atitude agrava a vida da população mais pobre que tem que se expor para ganhar o seu sustento, não podendo cumprir a quarentena para evitar a transmissão do vírus, adoecendo e morrendo mais do que aqueles podem se resguardar. Essa relação já está presente no canal Youtube, no qual observaram semelhança entre Jair Bolsonaro e Odorico Paraguaçu, personagem de novela de sucesso, que queria se beneficiar de uma certa epidemia.

Palavras chave: desigualdades; pandemia, necropolítica.
A flora na obra poética de Olegário Mariano
Authors: França Flávio , Souza Antônio Gabriel Evangelista de
Published: April 2022

Este estudo parte da hipótese que a análise da flora citada na obra literária pode fornecer dados para a compreensão da prática artística. Olegário Mariano Carneiro da Cunha (1889, Recife-1958, Rio de Janeiro) reuniu sua obra poética em Toda uma vida de Poesia (1957).  Ele recusou rótulos ao longo de sua carreira, tendo experimentado novas possibilidades. Este trabalho visa relacionar as plantas citadas nessa obra com aspectos artísticos; relacionar as espécies citadas aos significados propostos no poema; contribuir no estabelecimento do lugar do "poeta das cigarras" no contexto da literatura praticada em sua época. As espécies foram identificadas a partir dos dicionários, bem como foram utilizadas obras específicas da área de Botânica. Os seguintes poemas, ricos em citações de plantas, foram analisados: A) Uma canção por um beijo; B) O seio de Abraão; C) A casa dos sete cedros. A técnica de versificação foi analisada com base  tratados específicos. As espécies vegetais mais citadas foram: "Rosa" que foi o nome de planta mais referido com 64 citações (24,6%), seguido pelo "Lírio" (15 citações, 5,8%), "Cedro" (14 - 5,4%), "Manjerona" e "Cana-de-Açucar" (8- 3,1% cada), "Tomilho" (7 - 2,7%), "Mangueira" e "Uva (=Parra, Pâmpano)" (6- 2,3%), "Ninféia", "Salgueiro" e "Ipê", todos com 5 citações (1,9% cada). Foram um total de 83 espécies.  Observa-se a utilização de espécies exóticas à Flora Brasileira (48 espécies, c. 58 %).  O estudo revelou um escritor no meio do camimho entre "os mestres do passado" e o modernismo sendo um representante de um período muito delicado da literatura brasileira.
Composição florística da trilha ecológica do Parque Natural Municipal Fazenda Santa Cecília do Ingá, Volta Redonda, Rio de Janeiro, Brasil
Authors: Souza Vanusa Tubbs de , Souza Gilson Roberto de
Published: April 2022

O Parque Natural Municipal Fazenda Santa Cecília do Ingá, área de estudo deste trabalho, está localizado no Município de Volta Redonda, estado do Rio de Janeiro, sob as coordenadas latitude 22º27’34’’S e longitude 44º4’51’’W. Compreende 211 ha e sua vegetação é composta por Mata Atlântica em sucessão secundária. Este trabalho teve como objetivo contribuir para o conhecimento da flora na trilha ecológica e servir de subsídios para projetos de Educação Ambiental, para que se estabeleça a formação de trilhas interpretativas para proporcionar à população visitante, o entendimento dos aspectos de proteção dos recursos naturais. Utilizou-se 10 parcelas de 200m x 2,5m, totalizando 0,5 ha. As parcelas foram distribuídas ao longo das margens da trilha em ambos os lados. Foi considerado DAP (Diâmetro da altura do peito) superior a 5,0 somente para indivíduos arbóreos em estado reprodutivo ou vegetativo. As espécies herbáceas somente foram amostradas em estado reprodutivo. Foram amostrados 586 indivíduos, distribuídos em 47 famílias, 105 gêneros e 119 espécies de angiospermas. As famílias com maior representatividade de espécies foram Fabaceae (18), Asteraceae (18), Malvaceae (8), Euphorbiaceae (4), Melastomataceae (4), Solanaceae (4), Lamiaceae (4), Verbenaceae (3), Lauraceae (3) e Nyctaginaceae (2). As espécies com maior representatividade em número de indivíduos foram Clitoria fairchildiana R.A. Howard (50), Cecropia glaziovi Snethlage (25), Nectandra oppositifolia Nees (21), Miconia discolor DC. (18) e Allophylus edulis (St. Hil.) (13). Pela análise dos dados amostrados, pode-se considerar que a área de estudo é adequada e propícia para utilização em projetos de Educação Ambiental, aliado ao fato de ser uma das poucas áreas de remanescentes de Mata Atlântica no estado do Rio de Janeiro.
Developed and Field Performance Evaluation of a Combined Cultivator
Authors: Dahab Mohamed Hassan , Kheiry Abdalla N. O. , Numan Mohamed Hamid
Published: April 2022

Sugar cane production requires a number of operations to be carried out in the field through number of implements and machines. Therefore, time consuming and required large amount of energy. A combined field cultivator was designed in Kenana agricultural implements factory (KAIF) to carry out at one time multi operations (cultivation, furrow-reforming and Fertilizer placement). This is to increase field productivity, reduce farm power and lower operation time and cost. The combined implement was evaluated in Kenana cultivation fields and compared with three individual implements, rigid tine cultivator, furrow-reformer and fertilizer applicator. The measured parameters were drawbar pull, power requirements, field capacity, fuel consumption and total time in the field. The results showed highly significant differences at 1% level between the different implements for the field capacity, fuel consumption and significant differences at 5% for the drawbar pull. A power requirement in (kW) for the combined cultivator was 77% of those individual implements. Total time per feddan to accomplish the required operations by the combined cultivator was 57% of that required by the individual implements. Fuel consumption was reduced to 57% when combined implement was used compared to that consumed by individual implements. It was concluded that the combined cultivator was effective in increasing field productivity and reducing power and cost of operation.
The pedagogical potential of speech-language therapy materials for the teaching of idiomatic expressions in a foreign language
Authors: Rodríguez-Muñoz Francisco J.
Published: April 2022

This work suggests that greater permeability exists between the fields of speech-language therapy and foreign language teaching. A materials analysis was carried out to assess the pedagogical potential of a set of resources emanating from the Anglo-Saxon context. Specifically, seven material sources were selected that focus on pragmatic impairment, and the difficulties in learning idiomatic expressions (or idiomaticity deficit); these cover a publication period from 1992 to 2016. In addition, the strengthening of the links between psycholinguistic experimental research and the teaching of languages is asked for, including in the design of didactic materials. In this sense, the paper discusses the way in which a person with a pragmatic impairment, or a foreign language learner, processes an idiomatic phrase, as it considers that these psycholinguistic data are useful not only for clinical intervention, but also for creating effective didactic materials for the teaching of idiomatic expressions in a foreign language. Finally, regarding the materials analysed here, the typology of activities included in the older examples is reminiscent of structural language teaching methods, whereas, in materials published more recently, the influence of communicative methodologies is present.
Das IFCASL-Korpus als phonetisches Lernerkorpus
Authors: Trouvain Jürgen
Published: April 2022

Phonetic learner corpora represent a special type of spoken learner corpora by providing detailed phonetic and phonological annotation in the form of phonetic transcription as well as the segmentation and labelling of the speech signal on the levels of segments, syllables, words and sentences. This time-consuming post-processing enables a better acoustic analysis of the data and provides many options for using audio data in teaching foreign languages. It also offers good opportunities to develop tools for computer-aided pronunciation training. The possibilities and restrictions of phonetic learner corpora are illustrated with the bidirectional German–French IFCASL corpus.
Funktionale und stilistische Merkmale gesprochener fortgeschrittener Lerner:innensprache: Methodische und konzeptionelle Überlegungen am Beispiel von GeWiss
Authors: Fandrych Christian , Wallner Franziska
Published: April 2022

This article discusses some methodological and conceptual issues arising from the analysis of advanced-level spoken language corpora. This discussion is based onGeWiss,a corpus of spoken academic discourse comprising L1 and L2 data of German collected in academic settings in Poland, the UK, Bulgaria, and Germany, as well as L1 data of Polish, English, and Italian. The data were collected using an ethnographic comparative approach; a range of speech events with comparable institutional and functional features in the philologies (student presentations, research papers, and oral examinations) were identified, recorded, transcribed, and tagged. In addition to POS tagging and lemmatisation, in selected sub-corpora some pragmatic features were also annotated. These include metadiscursive actions as well as references and quotations. The corpus therefore comprises ‘natural data’, derived from various contexts, of speakers with varying degrees of academic socialisation and competence in academic German.

The paper discusses the various factors that have to be taken into account when analysing and evaluating the GeWiss L2 data with regard to style and register of metadiscourse as well as references and quotations in L2 student presentations. It is argued that any attempt to assess these data needs to reflect upon the concepts of ‘norm’, ‘appropriateness of usage’, (stage and context of) academic socialisation, and the context of the speech event. This also applies to the evaluation of the L1 data, which is why they cannot be used as a simple reference point for the purpose of a (mainly quantitative) ‘contrastive interlanguage analysis’ (Granger 2015). A qualitative approach needs to be used at least initially to identify and assess specific features of L2 data. This is shown using examples of metadiscursive and referencing speech actions. While there seem to be some stylistic and register features that can be regarded as inappropriate irrespective of the context of the speech events, others seem to be more context-sensitive. The paper argues that in addition to linguistic analysis and the intuitions of the L1 researcher, some kind of rating procedure would help to establish better concepts of ‘norm’ and ‘appropriateness’ of such natural corpus data originating in different academic contexts and traditions.
Bibliografija radova Vladimira Skračića
Authors: Jurić Ante
Published: April 2022

Bibliografija radova Vladimira Skračića