bluuebunny/crossref_metadata_2025 huggingface dataset:
3D Fuzzy Graphene Microelectrode Array for Neurotransmitter Sensing at Sub-cellular Spatial Resolution
Authors: Castagnola Elisa , Garg Raghav , Rastogi Sahil , Cohen-Karni Tzahi , Cui Xinyan Tracy
Published: November 2020

Dopamine (DA) is a monoamine neurotransmitter involved in the modulation of various physiological brain functions, including learning, motivation, reward, and motor functions. The development of a high sensitivity real-time sensor for multi-site detection of DA with high spatial resolution has critical implications for both neuroscience and clinical communities to improve understanding and treatments of neurological and neuropsychiatric disorders. Here, we present high-surface area out-of-plane grown three-dimensional (3D) fuzzy graphene (3DFG) microelectrode arrays (MEAs) for highly selective, sensitive, and stable DA electrochemical sensing. 3DFG microelectrodes present a remarkable sensitivity to DA (2.87 ± 0.25 nA/nM, withLOD of 990±15 pM), the highest reported for nanocarbon MEAs using Fast Scan Cyclic Voltammetry (FSCV). The high surface area of 3DFG allows for miniaturization of electrode down to 2 x 2 μm^2, without compromising the electrochemical performance. Moreover, 3DFG MEAs are electrochemically stable under 7.2 million scans of continuous FSCV cycling, present exceptional selectivity over the most common interferents in vitro with minimum fouling by electrochemical byproducts, and can discriminate DA and serotonin (5-HT) in response to the injection of their 50:50 mixture. These results highlight the potential of 3DFG MEAs as a promising platform for FSCV based multi-site detection of DA with high sensitivity, selectivity, and spatial resolution.
Nile Red-Based GPCR Ligands as Ultrasensitive Probes of the Local Lipid Microenvironment of the Receptor
Authors: Hanser Fabien , Marsol Claire , Valencia Christel , Villa Pascal , Klymchenko Andrey S. , Bonnet Dominique , Karpenko Iuliia
Published: November 2020

The local lipid microenvironment of transmembrane receptors is an essential factor in GPCR signaling. However, tools are currently missing for studying endogenously expressed GPCRs in primary cells and tissues. Here we introduce fluorescent environment-sensitive GPCR ligands for probing the microenvironment of the receptor in living cells using fluorescence microscopy under no-wash conditions. We designed and synthesized antagonist ligands of the oxytocin receptor (OTR) by conjugating a high-affinity non-peptidic OTR ligand PF-3274167 to the environment-sensitive fluorescent dye Nile Red. The length of the polar PEG spacer between the pharmacophore and the fluorophore was adjusted to lower the non-specific interactions of the probe while preserving a strong fluorogenic response. We demonstrated that the new probes embed into the lipid bilayer in the vicinity of the receptor and convey the information about the local polarity and the lipid order via the wavelength-shifting emission of the Nile Red fluorophore.
Modeling the Thermodynamics of Conformational Isomerism in Solution via Unsupervised Clustering: The Case of Sildenafil
Authors: Marinova Veselina , Dodd Laurence , Lee Song-Jun , P. F. Wood Geoffrey , Marziano Ivan , Salvalaglio Matteo
Published: November 2020

We present a systematic approach for the identification of statistically relevant conformational macrostates of organic molecules from molecular dynamics trajectories. The approach applies to molecules characterised by an arbitrary number of torsional degrees of freedom and enables the transferability of the macrostates definition across different environments. We formulate a dissimilarity measure between molecular configurations that incorporates information on the characteristic energetic cost associated with transitions along all relevant torsional degrees of freedom. Such metric is employed to perform unsupervised clustering of molecular configurations based on the fast search and find of density peaks algorithm. We apply this method to investigate the equilibrium conformational ensemble of Sildenafil, a conformationally complex pharmaceutical compound, in different environments including the crystal bulk, the gas phase and three different solvents (acetonitrile, 1-butanol, and toluene). We demonstrate that, while Sildenafil can adopt more than one hundred metastable conformational configurations, only 12 are significantly populated across all the environments investigated. Despite the complexity of the conformational space, we find that the most abundant conformers in solution are the closest to the conformers found in the most common Sildenafil crystal phase.
Rotaxanes as Cages to Control DNA Binding, Cytotoxicity and Cellular Uptake of a Small Molecule
Authors: Kench Timothy , Summers Peter A. , Kuimova Marina K. , Lewis James , Vilar Ramon
Published: November 2020

In this paper we report a unique approach to control the DNA interactions, cellular uptake and cellular localisation of a small molecule. We have designed rotaxanes that include a luminescent DNA binder, a macrocycle that modulates the DNA binding and a stopper that can be cleaved by either light or the activity of an enzyme.
Review of the School Completion Programme
Authors:   ESRI, Smyth Emer , Banks Joanne , Whelan Adele , Darmody Merike , McCoy Selina
Published: November 2020

The School Completion Programme (SCP) aims to have a significant positive impact on levels of student retention in primary and second-level schools. This report draws on a survey of SCP coordinators and chairpersons, in-depth case-studies of local clusters and interviews with key stakeholders to review the programme in terms of the students targeted, the kinds of activities offered, governance and funding, and perceived effects at the school level.
Infectious complications of aneurysmal subarachnoid hemorrhage
Authors: Polkovnikov О.Yu. , Materukhin A.М. , Kosyanchuk V.S. , Polkovnikova N.О.
Published: November 2020

Objective ‒ to assess the incidence of infectious complications in patients with aneurysmal subarachnoid hemorrhage (SAH); to determine the effect of the complicated course of aneurysmal SAH on the incidence of nosocomial infection.Materials and methods. The results of treatment of 250 patients in the acute period of aneurysmal SAH were analyzed, among them 124 observations (49.6 %) were identified, in which a complicated course of aneurysmal SAH was stated. In 185 cases, endovascular coiling was used to occlude the ruptured aneurysm, and in 65 cases the aneurysm was clipped. A group of patients who underwent infectious complications in the acute period of aneurysmal SAH was identified. The latter included: pneumonia, urinary tract infections, ventriculitis and meningitis.Results. The median age was 48.95 years (range 14 to 74 years). By gender, the majority were women ‒ 144 (57.6 %). Infectious complications were diagnosed in 52 (20.8 %) patients. Pneumonia was noted in 48 (19.2 %) cases. Urinary tract infections were observed in 36 (14.4 %) patients, in 7 (2.8 %) cases, infection of the nervous system (meningitis in 3 cases and ventriculitis in 4 cases). In the group of infectious complications, there were more observations referred to the group of complicated course of aneurysmal SAH ‒ 49 (92.3 %). Patients with severe SAH according to the WFNS, Hunt-Hess scales and the Fisher radiological scale prevailed. The average value was: WFNS ‒ 3.1 and Hunt‒Hess ‒ 3.7, according to the Fisher scale ‒ 3.5. Mortality in the group of infectious complications was 38.5 % (20 cases).Conclusions. Infectious complications occur with a frequency of 20.8 % and are a factor that worsens functional outcome and increases mortality in patients with aneurysmal SAH. Primary brain damage after rupture of an aneurysm, which determines the severity of SAH and the complicated course of the disease, is a predictor of the development of infectious complications.
Formación de Pares Evaluadores Externos a distancia virtual. Primera experiencia en Paraguay
Authors: Cuellar Garay María Bernarda , Patiño María Isabel , Parra Trepowski Oscar
Published: November 2020

El presente artículo tiene por objetivo central analizar las principales características del primer proceso formativo a distancia virtual de Pares Evaluadores Institucionales, llevado a cabo por la Agencia Nacional de Evaluación y Acreditación de la Educación Superior (ANEAES, Paraguay), en el marco de los procesos de aseguramiento de la calidad, implementados en el país. El estudio documental de carácter exploratorio utilizó como fuente primaria de información toda la documentación referida al modelo nacional de evaluación y acreditación del país, los documentos orientadores y reguladores, así como toda la referida al diseño del curso de formación de Pares Evaluadores Institucionales para Universidades e Institutos Superiores en su primera edición a distancia virtual, su implementación y los resultados obtenidos. La experiencia ha sido positiva en cuanto a la cantidad de profesionales que se presentaron a la convocatoria, el nivel de participación en las diversas actividades y en los foros de discusión. Los participantes han tenido un buen rendimiento, quedando seleccionados un total de 49 profesionales que pasaron a formar parte del Banco de Pares de la Agencia Nacional de Evaluación y Acreditación de la Educación Superior.
Uso de plataformas virtuales de aprendizaje en la formación de profesores de música en la Universidad Nacional de Asunción, años 2015 a 2018
Authors: Araujo Charruff María Azucena
Published: November 2020

El objetivo de esta investigación fue describir el mejoramiento en la eficacia y eficiencia de la formación de Profesores de Música con el uso de plataformas virtuales de aprendizaje como espacios de interacción didáctica, en la Universidad Nacional de Asunción. La metodología adoptada fue descriptiva con enfoque cuantitativo. Para la recolección de los datos fue elaborado un cuestionario, el cual se aplicó a docentes y alumnos. La población total está integrada por aproximadamente 246 estudiantes, variable según la inscripción semestral, 36 docentes, el director de la carrera y 5 docentes técnicos de la carrera de Licenciatura en Música desde marzo de 2015 hasta diciembre de 2018, vale decir 8 semestres académicos. Los resultados más significativos del estudio en relación a los docentes indicaron que los mismos tienen conocimiento sobre Entornos Virtuales de aprendizaje (EVA) y cursos a distancia, además tienen experiencias en el uso de plataformas digitales con fines educativos y académicos en alto índice. Los alumnos presentaron un desempeño considerado “mediano” en cuanto a sus capacidades para el uso educativo de las TIC. Se destacan como altas sus capacidades en el procesamiento de textos, uso de internet y correo electrónico, en lo concerniente a la administración del sistema informático, procesamiento de planillas electrónica, uso de herramientas de comunicación multimedia, se estima como de mediano nivel y la administración de base de datos como de bajo nivel de capacidades. En general promedian un rendimiento mediano.
Oseltamivir resistance in human seasonal influenza viruses (A/H1N1) in EU and EFTA countries: an update
Authors: Influenza Project Team
Published: November 2020

Following the publications in Eurosurveillance on 31 January [1,2], the European Centre for Disease Prevention and Control (ECDC), the European Influenza Surveillance Scheme (EISS), the World Health Organization (WHO) and their partners have agreed to update the data on the occurrence of resistance of influenza A/H1N1 viruses to oseltamivir appearing on the ECDC and EISS websites on a weekly basis (every Thursday afternoon). Data on the ECDC website are for European Union (EU) and European Free Trade Association (EFTA) countries. The WHO has also published a global table, which it will also refresh weekly. All these data are available through an HTML page on the ECDC web-site [3]. The European data made available through EISS and the EU DG Research-funded European Surveillance Network for Vigilance Against Viral Resistance (VIRGIL) are based on the data that have been uploaded to the EISS antiviral resistance data-base by a fixed time on a Wednesday for publication on a Thursday.
A case of situated learning and its implications for the development of translator competence
Authors: YILDIZ Mehmet
Published: November 2020

The task of translation schools should not be reduced to that of vocational schools, which can be claimed to favor ‘practice-intensive training’ over ‘theory-bound education’. However, this proposition does not annul the fact that practice is an integral component of translation education. Therefore, translation students should be offered real-world/authentic activities. In this sense, the present paper presents a situated-learning project conducted by the author and 62 first-year undergraduate students to investigate how a project-based situated learning approach can help translation students develop translator competence with particular focus on social competences. The students were asked to visit the restaurants in the City of Çanakkale, Turkey, and to identify translated menus in need of editing. They worked in 14 groups of three to six members. At the end of this two-week project, they were requested to provide the commissioner with an edited version of the menu and to submit the author a report. The contents of the reports were phenomenologically analyzed in view of Kiraly’s (2013) three social competences – professional etiquette, negotiation, and teamwork – and Eser’s (2015) interpersonal skills. The obtained results suggest that the project helped the participating students raise an awareness that translation is not only the production of a target text based on an assumed source text but also a process that entails acquisition and possession of efficacious interpersonal skills for the satisfactory completion of a translation task and observance of professional codes of behavior as a member of a professional community.
ENHANCED SEEKER OPTIMIZATION ALGORITHM FOR REDUCTION OF ACTIVE POWER LOSS
Authors: Lenin K.
Published: November 2020

This paper projects Enhanced Seeker Optimization (ESO) algorithm for solving optimal reactive power problem. Seeker optimization algorithm (SOA) models the deeds of human search population based on their memory, experience, uncertainty reasoning and communication with each other. In Artificial Bee Colony (ABC) algorithm the colony consists of three groups of bees: employed bees, onlookers and scouts. All bees that are presently exploiting a food source are known as employed bees. The number of the employed bees is equal to the number of food sources and an employed bee is allocated to one of the sources. In this paper hybridization of the seeker optimization algorithm with artificial bee colony (ABC) algorithm has been done to solve the optimal reactive power problem. Enhanced Seeker Optimization (ESO) algorithm combines two different solution exploration equations of the ABC algorithm and solution exploration equation of the SOA in order to progress the performance of SOA and ABC algorithms.  At certain period’s seeker’s location are modified by search principles obtained from the ABC algorithm, also it adjust the inter-subpopulation learning phase by using the binomial crossover operator. In order to evaluate the efficiency of proposed Enhanced Seeker Optimization (ESO) algorithm it has been tested in standard IEEE 57,118 bus systems and compared to other specified algorithms. Simulation results clearly indicate the best performance of the proposed Enhanced Seeker Optimization (ESO) algorithm in reducing the real power loss and voltage profiles are within the limits.
Bioethanol Production from Tapioca-Waste as Potential Additive Fuel for LCGC (Low-Cost Green Car)
Authors: Prastiwi Danty Oktiana , Anggita Novia , Arishandy Yudha Putra
Published: November 2020

The majority style of people in transportation is 24% contribute to increasing premium demand as energy. Unfortunately, fossil fuel is not renewable and limited quantity. Its means, potential biomass of tapioca waste should be an alternative energy source to solve that problem. Today, the biosystem of bioethanol production needs to be optimized to maximize filtration and minimize the production cost. First, composition and time incubation needs to be optimized. The research found that to fermented 50 g waste on 200 mL water, we need 2 g of yeast, and the time of harvesting optimum is fourth days with 17% ethanol. Without acid hydrolyze, tapioca waste in yeast fermentation serves 2600 ppm glucose on the first day and increases significantly on the second day with 2964.77 ppm glucose. This concentration found by DNS (Dinitrosalicylic acid) method. Yeast is the subject that converts glucose on medium to be ethanol. Secondly, that medium distillate gets pure ethanol. Thirdly, this ethanol mix with premium in some concentration, include 0%, 10%, 20%, 30%, 40%, 50%. This variant would do test emission to understand the advantages of tapioca bioethanol compare to fossil fuel. The result of this research should be support government to enhance LCGC (Low-cost green car) program to achieve lower air pollutants, green energy resolution, and cleaner production in tapioca industry.

 

Key Word: bioethanol, emission, formulation, LCGC, tapioca,
Pengaruh Layanan Konseling Individu dengan Teknik Modelling untuk Meningkatkan Motivasi Belajar di SMA Negeri 1 Tambakboyo
Authors: Prihatiningtia Prihatiningtia
Published: November 2020

Buruknya konsep diri pada remaja salah satunya dapat dilihat dari adanya ketidakpercayaan diri. Siswa yang percaya diri yakin atas kemampuan diri serta memiliki pengharapan yang realistis.Tujuan penelitian eksperimen ini adalah mengurangi pengharapan tidak realistis dengan menggunakan teknik instruksi diri yang dapat mengarahkan siswa untuk mengontrol perilaku dan pemikiran-pemikiran negatif yang menimbulkan rendahnya rasa percaya diri (overt-covert). Hasil analisis uji wilcoxon menunjukkan bahwa sig. (2-tailed) 0,042<0,05 yang dapat diartikan teknik self instruction dapat meningkatkan kepercayaan diri siswa SMP Muhammadiyah 4 Singosari dengan taraf signifikan 5%. Penggunaan teknik self instruction sebagai alternatif teknik untuk meningkatkan kepercayaan diri siswa dimulai dari prosedur rasional, bimbingan diri sendiri, overt eksternal guidance, overt self guidance, faded overt self guidance, covert self guidance, dan homework.
KAPSARC Oil Market Outlook
Authors:   KAPSARC (King Abdullah Petroleum Studies and Research Center)
Published: November 2020

The global oil market moved into deficit in the third quarter of this year and is expected to remain in deficit during the next eight quarters. We expect the deficit to range between 3.4 – 0.1 million barrels per day (MMb/d) until OPEC ends its cuts in April 2022. The most significant drivers of the shift have been the recovery of global demand and the strong compliance of OPEC members and OPEC partners (OPEC+) with the production cuts agreed by OPEC+ at the group’s historic April meeting.
Pengaruh Variasi Tekanan Negatif Suction Endotracheal Tube (ETT) Terhadap Nilai Saturasi Oksigen (SpO2)
Authors: Suparti Sri
Published: November 2020

Pasien kritis yang terpasang endotracheal tube (ETT) dan ventilasi mekanik di Intensive Care Unit (ICU) membutuhkan tindakan suction untuk membersihkan dan mempertahankan kepatenan jalan nafas. Suction ETT selain manfaatnya juga bisa menyebabkan dampak negatif seperti penurunan saturasi oksigen, trauma, hipoksemia, bronkospasme, kecemasan bahkan menstimulasi peningkatan tekanan intravaskular. Tujuan penelitian ini adalah menganlisis pengaruh variasi tekanan negatif suction terhadap nilai saturasi oksigen pasien yang terpasang ventilator di ICU. Jenis penelitian adalah experimen semu (quasi experiment), dengana desain two group pretest-postest, total sampel adalah 37 yang diambil dengan teknik consecutive sampling. Kriteria inklusi pasien dewasa ≥ 15 tahun, terpasang ETT dan ventilator. Adapun kriteria eksklusi adalah pasien hanya mendapatkan suction 1 kali, dalam kondisi t-piece, diagnosis pneumonia dan observasi tidak lengkap.Variabel bebas adalah tekanan negatif suction dan variabel dependent adalah  saturasi oksigen. Analisis data menggunakan uji paired t-test dan independent t-test dengan signifikasi 5%. Etik penelitian diperoleh dari komite Etik RS RSUD Prof. Dr. Margono Soekarjo dengan No: 420/004349/I/2019. Hasil penelitian menujukan terdapat pengaruh variasi tekanan negatif 25 dan 25 kPa terhadap nilai saturasi oksigen pada analisis masing-masing kelompok dengan perbedaan nilai mean yang signifikan p value 0,001<0,05, tetapi tidak terdapat perbedaan signifikan diantara dua kelompok dengan p value 0,284>0,05. Kesimpulan penelitian ini menunjukkan tekanan negatif 25 kPa lebih efektif dalam mengeluarkan sekresi sekret pada jalan nafas dan memungkinkan penigkatan saturasi oksigen setelah tindakan suction pada pasien dengan ventilator dibandingkan dengan tekanan 20 kPa.
PENGARUH SEDIAAN DEKOK DAUN ZAITUN (Olea europaea L.) TERHADAP PENURUNAN TEKANAN DARAH PADA TIKUS PUTIH GALUR WISTAR (Rattus norvegicus strain wistar) JANTAN YANG DIINDUKSI NATRIUM KLORIDA 5,5%
Authors: Mubarok Fachri , Kusumawinakhyu Titik , Bahar Yenni
Published: November 2020

According toWHOhypertension about 26.4% of world population who have suffered hypertension. It wouldprobably increase up to 29.2% in 2025.  Usually,hypertension medical care uses convensional medicine, however itpossessessome side effects and could causecomplication.For that reason, herbal medicine is needed for safer andmore effective purpose.  One of herbal medicines is olive leaf (Olea europea L).It aimed to figure out effect of oliveleaf extract (Olea europaea L.) on declining blood pressurein whitemale rat wistar strain (Rattus novergicus strainwistar) after 5.5% Natrium Chloride (NaCl) induction.24 of rats were divided into 4 groups of treatments and 5.5%NaCl inductions. Group I, as a control withaquadest treatment, Group II was inducted with 540 mgs of olive leafextract, Group III was inducted with 1080mgs of olive leaf extract, and Group IV was inducted with 2160 mgs ofolive leaf extract. Data were Analyzed byOne way ANOVA then followed with Post-hoc test using LeastSignificant Differences (LSD) test. From the group I, the mean of pretest was 117.83/150.83mmHg and  the meanof post test was117.83/141.67 mmHg. Group II, the mean of pretest was 123.67/156,00 mmHg and the mean of posttest was87.00/116,00 mmHg. Group III, the mean of pretest was 123.50/156.83 mmHg and  the mean of post testwasand  the mean of post test was 81.67/112,50 mmHg. Group IV the mean of pretest was 119.00/156.50 mmHgandthe mean of post test was 80.00/105.00 mmHg.There were effects of olive leaf extract (Olea europaea L.) in 540mgs, 1080 mgs and 2160 mgs toblood pressure declining in white male rat wistar strain (Rattus novergicus strainwistar) after 5.5% NatriumChloride (NaCl) induction.  The higest blood pressure declining was in Group IV of 2160mg olive leaf extractinduction.
Axial Skeletal Malformations in Genetically Modified Xenopus laevis and Xenopus tropicalis
Authors: Zlatow Anne L , Wilson Sabrina S , Bouley Donna M , Tetens-Woodring Joanne , Buchholz Daniel R , Green Sherril L
Published: November 2020

Skeletal malformations in captive-bred, adult Xenopus spp., have not previously been reported. Here we describe 10 sexually mature, genetically modified laboratory frogs (6 Xenopus laevis and 4 Xenopus tropicalis) with axial skeletal abnormalities. The young adult
frogs were described by veterinary staff as presenting with "hunchbacks," but were otherwise considered to be in good health. All affected frogs were genetically engineered using various techniques: transcription activator-like effector nucleases (TALEN) editing using thyroid hormone receptor
α TALEN mRNA, restriction enzyme-mediated integration methods involving insertion of the inducible transgene pCAR/TRDN, or via I-SceI meganuclease transgenesis using either pDRTREdpTR-HS4 or pDPCrtTA-TREG-HS4 plasmid sequences. Radiographic findings (6 frogs) and gross necropsy
(10 frogs) revealed vertebral column malformations and sacroiliac deformities that resulted in moderate to severe kyphosis and kyphoscoliosis. These findings were confirmed and additional skeletal abnormalities were identified using computed tomography to create a 3D reconstruction of 4 frogs.
Additional findings visible on the 3D reconstructions included incomplete vertebral segmentation, malformed transverse processes, and a short and/or curved urostyle. Histopathologic findings included misshapen intervertebral joints with nonconforming articular surfaces, narrowed joint cavities,
flattened or irregularly-formed articular cartilage, irregular maturation lines and nonpolarized chondrocytes, excess fibrocartilage, and evidence of irregular bone resorption and growth. While the specific etiology of the vertebral skeletal abnormalities remains unclear, possibilities include:
1) egg/oocyte physical manipulation (dejellying, microinjection, fertilization, etc.), 2) induction and expression of the transgenes, 3) inactivation (knockout) of existing genes by insertional mutagenesis, or 4) a combination of the above. Furthermore, the possibility of undetected changes
in the macro or microenvironment, or a feature of the genetic background of the affected frogs cannot be ruled out.
The Finnish verbs of falling
Authors:   University of Helsinki, Viimaranta J. , Protassova M. ,   University of Helsinki
Published: November 2020

In Finnish, a Finno-Ugric language, many different verbs are used to describe the process of falling. They differ in meaning according to the trajectory, the characteristics of the falling object, and the process of landing. The list of verbs of falling was compiled with the help of dictionaries, corpus material, and native and multilingual speakers of Finnish. After completing the list of verbs, the authors collected examples of the use of the chosen ca. 40 verbs (in some cases, different Aktionsarten were also included). The main corpus of examples was retrieved from the Language Bank of Finland, available online at www.korp.csc.fi. The examples illustrated the direct, special, and metaphoric meanings of the verbs. After comparing the contexts where different verbs were used, it was found that the most frequent verbs are pudota, tippua (falling from above to the ground), kaatua (falling from a vertical position into a horizontal one) and romahtaa (collapse). The first two verbs may replace each other in almost all contexts. Although the primary meanings of the other verbs are often different, they may have very similar metaphoric meanings, especially when people speak of their mental state. The other verbs described in this study are: alentua ‘become lower, go down, fall, sink’, aleta ‘become lower’, kellahtaa ‘fall, tumble down, topple over’, kellistyä ‘fall, tumble (down), fall down’, kierähtää ‘fall, tumble over, stumble, flip over, turn over’, kolahtaa ‘bang, slam, hit, bump, clunk, go down well’, kompastua ‘trip, stumble, trip up’, kopsahtaa ‘thump, clap, click, fall with a thump’, kupsahtaa ‘topple, topple over, tumble over, pop off’, kuukahtaa ‘topple, topple over, tumble over, pop off’, langeta ‘fall, throw’, laskea ‘lower, reduce, fall, drop, go down’, lätsähtää ‘splash, belly-flop’, leijailla ‘float, soar, hover’, lentää ‘fly’, loiskahtaa ‘splash, spill’, luhistua ‘collapse, cave in, fall in, break down, fall apart’, lysähtää ‘collapse, sink, drop, slump, flop’, lyyhistyä ‘collapse, fall down, sink, drop, slump’, molskahtaa ‘splash, plop’, painua ‘sink, fall’, plätsähtää ‘splash’, roiskahtaa ‘splash, splatter, spurt out’, romahtaa ‘collapse, tumble down, fall down, crash down, cave in, topple over’, sortua ‘collapse, fall down, cave in, crash down’, tömähtää ‘thump, thud’, tuupertua ‘collapse, drop, sink, fall down’, vajota ‘sink, fall’, valua ‘flow, run, drip’, varista ‘fall off, drop off’, and vierähtää ‘roll, elapse’.
Leiomiossarcoma de cólon
Authors:   Hospital 9 de Julho - São Paulo, SP, Brasil, Pereira Luiz Claudio Landolfi , Barril Caio Henrique Carrichio , Pereira Lucas Abdo , Arjona Beatriz Merotti , Pereira Thais Abdo ,   Faculdade de Medicina do ABC - Santo André, SP, Brasil,   Universidade de Santo Amaro - Faculdade de Medicina - São Paulo, SP, Brasil
Published: November 2020

Leiomiossarcomas primários do trato gastrointestinal são tumores extremamente raros e muito agressivos, apenas poucos trabalhos relatando a doença desde o estabelecimento do conceito dos tumores estromais do sistema digestório foram relatados. Reportamos um caso de leiomiossarcoma primário de cólon transverso e revisão de literatura.
SENAM BERSAMA MASYARAKAT BONTOCINI
Authors: Anriani Titik
Published: November 2020

Kegiatan senam ini dilakukan setelah sholat Ashar tempatnya yaitu di halaman mesjid Al-ikhlas desa Bontocini. Senam berlangsung selama kurang lebih 1 jam
Profiles and trajectories of mental health service utilisation during Early Intervention in Psychosis
Authors: O'Driscoll Ciarán , Shaikh Madiha , Finamore Chloe , Platt Bradley , Pappa Sofia , Saunders Rob
Published: November 2020

Background Early intervention in psychosis services (EIS) support individuals experiencing a first episode of psychosis. Support required will vary in response to the remittance and reoccurrence of symptoms, including relapses. Characterising individuals who will need more intensive support can inform care planning. This study explores service utilisation profiles and their trajectories of service use in a sample of individuals referred to EIS.Method We analysed the different services accessed during the 3 years following referral to EIS for individuals (n = 2363) in West London between 2011 and 2020. Mental health service utilisation data were submitted to model-based clustering. Latent growth models were estimated for identified profiles. Profiles were compared regarding clinical and demographic characteristics and onward pathways of care.Results: Analyses revealed 5 profiles of individuals attending EIS based on their service utilisation over 3 years. 55.5% of the sample were members of a low utilisation and less clinically severe profile. The distinct service use patterns of these profiles were associated with baseline HoNOS scores (at the total, subscale, and individual item level), along with age and gender. These patterns of use were also associated with onward care and ethnicity.Conclusions: Profiles and trajectories of service utilisation call for the development of integrated care pathways and the use of personalised interventions. Services should consider patient symptoms and characteristics when making clinical decisions informing the provision of care. The profiles represent typical patterns of service use, and identifying factors associated with these subgroups might help optimise EIS support.
Jurnay Natalia Sholla
Authors: Sholla Natalia
Published: November 2020

Pola apologetika kontekstual untuk memberitakan kabar baik kepada gereja kibaid jemaat marinding
Profesionalisme Driver Transportasi Online
Authors: yunus mahmud
Published: November 2020

KATA PENGANTARSegala puji dan syukur kehadirat Allah Swt. yang telah melimpahkan rahmat-Nya. Berkat karunia-Nya, peneliti dapatmenyelesaikan buku yang berjudul “Profesionalisme DriverTransportasi Online”. Buku ini dapat diselesaikan berkat bantuandari berbagai pihak. Oleh karena itu, peneliti menyampaikan ucapan terima kasih dan penghargaan setinggi-tingginya kepada pihak-pihak yang telah membantu penyelesaian buku ini.Transportasi online memberikan manfaat untuk memudahkandalam bertransportasi, membuka lapangan kerja danmeningkatkan pertumbuhan ekonomi. Disisi lain transportasionline memberikan dampak negatif seperti konflik antara driverdengan transportasi konvensional, praktik kecurangan oknumdriver, pelanggaran tata tertib oleh oknum driver dan perilakukurang profesional oknum driver dalam menjalankan pekerjaanya.Fokus masalah penelitian ini adalah profil driver transportasionline, motif memilih profesi driver transportasi online, dampakpenghargaan dan sanksi terhadap kinerja driver transportasionline dan penguatan profesionalisme driver transportasi online.
Pendidikan Dan Pendampingan Terhadap Anak Sekolah Minggu Untuk Memaknai Tujuan Dari Pak Yakni Yesus Kristus Sebagai Tuhan
Authors: Limbong Jeni Tandi
Published: November 2020

Adapun tujuan mengangkat tulisan ini adalah supaya ada pemahaman yang baik akan pentingnya pendampingan dan pendidikan bagi anak melalui lembaga pendidikan sekolah minggu yang di selenggarakan oleh gereja agar anak sekolah Minggu mendapat perhatian dan pendidikan serta pendalaman tentang Yesus Kristus sebagai Tuhan dalam pendidikan Agama Kristen, anak sekolah minggu tahu atau memaknai spiritual mereka dengan benar. Selain itu juga adanya pemahaman mengenai pentingnya pelayanan sekolah minggu untuk menjadi wabah dalam menjangkau orang-orang bagi kristus. Adapun metode yang digunakan adalah metode literature atau pustaka dengan pendekatan kualitatif . adapun sumber-sumber bacaan yaitu kumpulan jurnal-jurnal dan buku dan web internet. Teori yang ada berdasarkan kutipan dari jurnal, buku dan web situs internet.
Pengaruh Media Sosial Terhadap Minat Belajar Mahasiswa IAKN Toraja
Authors: Yustus
Published: November 2020

Abstrak: Perkembangan teknologi sangat pesat seiring berjalannya waktu baik di Negara berkembang maupun di negara maju, khususnya di Indonesia yang termasuk negara berkembang. Iptek merupakan berkat Allah kepada manusia untuk memperoleh kesejahteraan hidup jasmani dan rohani. Manusia dalam mengupayakan, mengembangkan dan memanfaatkan ilmu pengetahuan serta teknologi dilandasi suatu keyakinan bahwa Allah memberi kuasa kepadaa manusia sebagai Imagodei untuk menaklukkan dan menguasai alam termasuk pengupayaan penguasaan ilmu pengetahuan dan teknologi (kejadian 1:26-28). . Ketika mahasiwa memiliki minat yang tinggi terhadap pelajaran maka mahasiswa tersebut akan belajar dengan baik dan berusaha untuk mengetahui dan memahami apa yang di ajarakan kepadanya. Media sosial memiliki potensi untuk di kembangkan dalam pendidikan Indonesia, dilihat dari dua sisi yaitu jumlah pengguna dan sifat media sosial
MISI APOLOGETIKA KRISTEN TERHADAP PERTUMBUHAN IMAN PEMUDA GEREJA TORAJA MAMASA (PGTM) DI JEMAAT OROBUA
Authors: Yustus
Published: November 2020

ABSTRAK: Keadaan dunia kini telah mengalami perkembangan yang sangat pesat dan terus berubah, menjadikan nilai dan tatanan kehidupan juga berubah, terutama bagi pemuda sangat terpengaruh keadaan spiritual dan sosialnya. Sehingga tanpa adanya pembinaan secara rohani hal dapat itu menjadi halangan mereka dalam menerima Injil atau Berita Sukacita. Maka orang percaya khususnya gereja perlu mengembangkan sistem/bentuk pemberitaan yang baru, bagi kaum muda. Pemuda merupakan garda terdepan dalam kehidupan Gereja, akan tetapi jika tidk memiliki Iman yang berpusat pada Yesus, maka hal tersebut akan menjadikan hidup anak muda tidak berkualitas. Artikel ini bertujuan mengkaji bagaimana pola apologetika Kristen dalam meningkatkn Iman pemuda di Gereja Toraja Mamasa dalam menghadapi era dirupsi atau perubahan yang serba cepat. Penelitian ini menggunakan metode analisis literature dan pendekatan kualitatif untuk mengurai permasalahan yang ada di jemaat Orobua sesennapadang, bagaimana kemerosotan hidup anak muda, khususnya dalam Gereja jemaat Orobua.
Misi Apologetika Kristen Online di Aplikasi Discord pada Komunitas Server Among Us Indonesia
Authors: Meylano Artahsasta
Published: November 2020

Revolusi Industri 4.0 tidak dapat terhindarkan. Indonesia salah satu negara yang terdampak era ini, ditambah dengan adanya pandemi covid-19 mengakibatkan terjadinya disrupsi yang sangat cepat, perubahan tatanan kehidupan. Kehidupan manusia mulai beralih ke dunia online dengan penggunaan aplikasi. Salah satu aplikasi yang hits saat ini adalah game Among Us yang memberikan dampak positif kepada aplikasi Discord. Discord saat ini tidak hanya menjadi sarana komunikasi dalam bermain game, tetapi menjadi tempat untuk bersosialisai dan saling diskusi. Melihat fenomena yang terjadi saat ini di Discord, menjadi suatu tantangan bagi setiap misi yang ada di Indonsia. Hal ini bisa dilakukan dengan pembuatan metode apologetika. Tujuan dari artikel ini adalah menghasilakn metode Apologetika Kristen online di Discord pada komunitas server Among Us Indonesia. Penelitian ini menggunakan Metode Kualitatif, dengan jenis penelitian studi kasus. Pengumpulan datanya dari observasi langsung secara interaktif dan melalui studi pustaka. Penelitian ini menghasilkan metode Apologetika Kristen Online di Discord pada Komunitas Server Among Us Indonesia yang terdiri atas: Perencanaan, Pengorganisasian, dan Pelaksanaans serta Evaluasi.
Tensor volume exploration using attribute space representatives
Authors: Jankowai Jochen , Skånberg Robin , Jönsson Daniel , Ynnerman Anders , Hotz Ingrid
Published: November 2020

While volume rendering for scalar fields has been advanced into a powerful visualisation method, similar volumetric representations for tensor fields are still rare. The complexity of the data challenges not only the rendering but also the design of the transfer function. In this paper we propose an interface using glyph widgets to design a transfer function for the rendering of tensor data sets. Thereby the transfer function (TF) controls a volume rendering which represents sought after tensor-features and a texture that conveys directional information. The basis of the design interface is a two-dimensional projection of the attribute space. Characteristicrepresentatives in the form of glyphs support an intuitive navigation through the attribute space. We provide three different options to select the representatives: automatic selection based on attribute space clustering, uniform sampling of the attribute space, or manually selected representatives. In contrast to glyphs placed into the 3D volume, we use glyphs with complex geometry as widgets to control the shape and extent of the representatives. In the final rendering the glyphs with their assigned colors play a similar role as a legend in an atlas like representation. The method provides an overview of the tensor field in the 3D volume at the same time as it allows the user to explore the tensor field in an attribute space. We demonstrate the flexibility of our approach on tensor fields for selected data sets with very different characteristics.
Dampak Injil bagi pemuda yang kurang aktif di persekutuan
Authors: TAKKE MELI
Published: November 2020

I raised this title because I saw in my congregation most of the youths who were less active in fellowship either in church or other services, so this made me think that how the role of the gospel is so that i can have a good impact on youth who are less active in Chiristianly. Because youth are the next generation of the church, it is very important for youth to be active in a fellowship because from there the youth begin to learn and develop their potential. The gospel is one of the (spiritual) needs of our lives. The gospel is good news. Where we as Christians, especially in the ministry, there is our role to preach the gospel. The purpose of this study is to further explain how the impact of the gospel on youth who are less active in the fellowship, the method used in this study is a qualitative method because this research focuses more on theory.
Teaching and Learning During the COVID-19 School Lockdown: Realization and Associations with Parent-Perceived Students’ Academic Outcomes—A study and preliminary overview
Authors: Steinmayr Ricarda , Lazarides Rebecca , Weidinger Anne , Christiansen Hanna
Published: November 2020

Due to the COVID-19 pandemic, all schools in Germany were locked down for several months in 2020. How schools realized teaching during the school lockdown greatly varied from school to school. N = 2647 parents participated in an online survey and rated the following activities of teachers in mathematics, language art (German), English, and science/biology during the school lockdown: frequency of sending task assignments, task solutions and requesting for solutions, giving task-related feedback, grading tasks, providing lessons per videoconference, and communicating via telecommunication tools with students and/or parents. Parents also reported student academic outcomes during the school lockdown (child’s learning motivation, competent and independent learning, learning progress). Parents further reported student characteristics and social background variables: child’s negative emotionality, school engagement, mathematical and language competencies, and child’s social and cultural capital. Data were separately analyzed for elementary and secondary schools. In both samples, frequency of student-teacher communication was associated with all academic outcomes, except for learning progress in elementary school. Frequency of parent-teacher communication was associated with motivation and learning progress, but not with competent and independent learning, in both samples. Other distant teaching activities were differentially related to students’ academic outcomes in elementary vs. secondary school. School engagement explained most additional variance in all students’ outcomes during the school lockdown. Parent’s highest school leaving certificate incrementally predicted students’ motivation, and competent and independent learning in secondary school, as well as learning progress in elementary school. The variable “child has own bedroom” additionally explained variance in students’ competent and independent learning during the school lockdown in both samples. Thus, both teaching activities during the school lockdown as well as children’s characteristics and social background were independently important for students’ motivation, competent and independent learning, and learning progress. Results are discussed with regard to their practical implications for realizing distant teaching.
BERJALANYA PROSES PELAYANAN DI RUMAH SAKIT DENGAN BAIK DIBANTU PERAN PASIEN DAN KELUARGA SEBAGAI PARTNER SERTA TERHINDAR DARI BAHAYA
Authors: Sianipar Yudistira
Published: November 2020

Keselamatan menjadi isu global dan terangkum dalam lima isu penting yang terkait di rumah sakit yaitu keselamatan pasien, keselamatan pekerja atau petugas kesehatan, keselamatan bangunan dan peralatan di rumah sakit, keselamatan lingkungan dan keselamatan bisnis rumah sakit yang terkait dengan kelangsungan hidup rumah sakit. Rumah sakit adalah suatu organisasi yang dilakukan oleh tenaga medis profesional yang terorganisir baik dari sarana prasarana kedokteran yang permanen, pelayanan kedokteran, asuhan keperawatan yang berkesinambungan, diagnosis serta pengobatan penyakit yang diderita oleh pasien. Rumah sakit mempunyai berbagai macam jenis pelayanan kesehatan yang dapat diunggulkan untuk mempertahankan loyalitas pasien. Upaya untuk meningkatkan keselamatan pasien dan mutu pelayanan kesehatan memerlukan peran aktif pasien, keluarga atau orang lain yang menemani‐merawat pasien (carers) dan masyarakat (untuk selanjutnya disebut pasien‐masyarakat). Pasien dapat melakukan banyak peran penting ketika menerima pelayanan kesehatan. Pasien dapat berperan untuk membantu menemukan diagnosis yang akurat, memutuskan pengobatan yang dipilih, menetapkan dokter/rumah sakit yang kompeten, memastikan monitoring dan kepatuhan pengobatan, serta mengidentifikasi efek samping dan melakukan tindakan segera yang tepat bila terjadi efek samping (Vincent & Coulter, 2002). Banyak hal buruk yang mungkin tidak di inginkan bisa saja terjadi .Untuk menghindari bahaya tersebut diperlukan ketelitian dan ketekunan dari tenaga medis.
MISI GURU PAK DALAM LINGKUP ANAK SEKOLAH MINGGI DI JEMAAT GKII GE'TENGAN
Authors: Yanti Risva
Published: November 2020

Dalam terwujudnya sebuah misi tentunya banyak tantangan yang dihadapi baik dari pribadi maupun dari lingkungan sekitar. Dalam misi Allah Yesus sendiri yang berperan secara langsung didalamnya, kemudian setelah itu Yesus mengajak murid-murid-Nya untuk mewujudkan misi itu melalui Pemuridan, atau menjadikan semua bangsa murid-Nya. Yesus berpesan bahwa jangan takut Dia akan menyertai kita kemanapun kita pergi. Yesus tidak memandang siapa yang akan di ajar atau siapa yang akan dijadikan murid. Dalam konteks ini misi sesorang berbeda-beda dalam cara mewujudkannya, ada yang memulai misi pemuridan mereka dari anak kecil hingga orang dewasa. Misi Guru Pak dalam lingkup sekolah minggu memaparkan tentang bagaimana peran seorang Guru, apa yang menjadi tanggujawabnya dalam memuridkan anak-anak sejak dini. Tugas tanggung jawab seorang guru itu tidaklah mudah namun punya tanggungan yang sangat besar.
Gold nanoparticles-assisted plasmonic enhancement for DNA detection on the graphene-based portable SPR sensor
Authors: Prabowo Briliant Adhi , Purwidyantri Agnes , Liu Bei , Lai Hsin-Chih , Liu Kou-Chen
Published: November 2020

The impact of different gold nanoparticles (GNPs) structures on the plasmonic enhancement for DNA detection is investigated on a few-layer graphene (FLG) surface plasmon resonance (SPR) sensor. Two distinct structures of gold nanourchins (GNu) and gold nanorods (GNr) were used to bind the uniquely designed single-stranded probe DNA (ssDNA) of Mycobacterium tuberculosis complex (MTBC) DNA. The two types of GNPs-ssDNA mixture were adsorbed onto the FLGcoated SPR sensor through the π-π stacking force between the ssDNA and the graphene layer. In the presence of the complementary single-stranded DNA (cssDNA), the hybridization process took place and gradually removed the probes from the graphene surface. From SPR sensor preparation, the annealing process of the Au layer of the SPR sensor effectively enhanced the FLG coverage leading to a higher load of the probe DNA onto the sensing interface. The FLG was shown effective in providing a larger surface area for biomolecular capture due to its roughness. Carried out in the DNA hybridization study with SPR sensor, GNu, with its rough and spikey structures, significantly reinforced the overall DNA hybridization signal than the GNr with smooth superficies, especially in capturing the probe DNA. The DNA hybridization detection assisted by GNu reached the femtomolar range limit of detection (LoD). An optical simulation validated the extreme plasmonic field enhancement at the tip of the GNu spicules. The overall integrated approach of graphene-based SPR sensor and GNu-assisted DNA detection provided the proof-of-concept for the possibility for Tuberculosis disease screening using a low-cost and portable system potentially applied in remote or third world countries.
GGMncv: Nonconvex Penalized Gaussian Graphical Models in R
Authors: Williams Donald Ray
Published: November 2020

Studying complex relations in multivariate datasets is a common task across the sciences. Recently, the Gaussian graphical model has emerged as an increasingly popular model for characterizing the conditional dependence structure of random variables. Although the graphical lasso ($\ell_1$-regularization) is the most well-known estimator, it has several drawbacks that make it less than ideal for model selection. There are now alternative forms of regularization that were developed specifically to overcome issues inherent to the $\ell_1$-penalty.To date, however, these alternatives have been slow to work their way into software for research workers. To address this dearth of software, I developed the package \textbf{GGMncv} that includes a variety of nonconvex penalties, two algorithms for their estimation, plotting capabilities, and an approach for making statistical inference. As an added bonus, \textbf{GGMncv} can be used for nonconvex penalized least squares. After describing the various nonconvex penalties, the functionality of \textbf{GGMncv} is demonstrated through examples using a dataset from personality psychology.