bluuebunny/crossref_metadata_2025 huggingface dataset:
High frequency electrical stimulation reduces α-synuclein levels and α-synuclein-mediated autophagy dysfunction
Authors: George Jimmy , Shafiq Kashfia , Kapadia Minesh , Kalia Lorraine V. , Kalia Suneil K.
Published: July 2024

Accumulation of α-synuclein (α-Syn) has been implicated in proteasome and autophagy dysfunction in Parkinson’s disease (PD). High frequency electrical stimulation (HFS) mimicking clinical parameters used for deep brain stimulation (DBS) in vitro or DBS in vivo in preclinical models of PD have been found to reduce levels of α-Syn and, in certain cases, provide possible neuroprotection. However, the mechanisms by which this reduction in α-Syn improves cellular dysfunction associated with α-Syn accumulation remains elusive. Using HFS parameters that recapitulate DBS in vitro, we found that HFS led to a reduction of mutant α-Syn and thereby limited proteasome and autophagy impairments due to α-Syn. Additionally, we observed that HFS modulates via the ATP6V0C subunit of V-ATPase and mitigates α-Syn mediated autophagic dysfunction. This study highlights a role for autophagy in reduction of α-Syn due to HFS which may prove to be a viable approach to decrease pathological protein accumulation in neurodegeneration.
Verbena officinalis (VO) leaf extract as an anti-corrosion inhibitor for carbon steel in acidic environment
Authors: Fouda Abd El-Aziz S. , Molouk Ahmed F. , Atia Mohamed F. , El-Hossiany Ahmed , Almahdy Mohamed S.
Published: July 2024

In the present work, Verbena Officinalis (VO) leaf extract was used as potential corrosion inhibitor for the corrosion of carbon steel (CS) in 0.5 M H2SO4 medium. Further, the corrosion inhibiting nature of VO leaf extract towards the CS was evaluated using mass loss (ML), potentiodynamic polarization (PDP), electrical impedance spectroscopy (EIS) and surface morphological analyses using atomic force microscope (AFM) and X-ray photoelectron spectroscopy (XPS) techniques. Calculation of activation energy $$\left( {{\text{E}}_{{\text{a}}}^{*} } \right)$$

E

a

∗

using Arrhenius equation shows the increase in activation energy when adding the VO leaf extract in 0.5 M H2SO4 medium and the maximum activation energy ($${\text{E}}_{{\text{a}}}^{*}$$

E

a

∗

 = 49.9 kJ mol−1) was observed for 1000 mg L−1 VO leaf extract in acid medium. The negative free energy values suggested the spontaneous and the stability of the adsorbed layer of VO leaf extract on the CS surface. Using EIS measurements, high percent inhibitory effectiveness of 91.1% for 1000 ppm solutions was achieved. With an increase in VO leaf extract dose, the double layer capacitance (Cdl) values fall while the values of charge transfer (Rct) increase. This showed that a protective layer of VO leaf extract on CS surface was formed. The polarization curves showed that the VO leaf extract acts as a mixed-type inhibitor. It is discovered that the adsorption of VO leaf extract molecules adhering to the CS surface followed the Langmuir isotherm. The anti-corrosion action of VO leaf extract is fully demonstrated by some surface techniques.
Contrast efficacy of novel phase convertible nanodroplets for safe CEUS imaging
Authors: Riaz R. , Shafiq S. , Fatima M. , Siddique M. A. , Shah S. , Abbas S. R.
Published: July 2024

Microbubble contrast agents in ultrasound/echocardiography are used to increase the echogenicity of the target tissues, thereby raising the contrast resolution of the resultant image. Recently, the trend has shifted toward the development of phase-convertible nanodroplets as ultrasound contrast agents due to their promising theragnostic potential by switching capability at the active site. Herein, we fabricated pre-PGS- perfluoropentane phase convertible nanodroplets and checked their in vitro and in vivo enhancement and safety profile. For this, we performed experiments on 20 male Wistar rats and 2 dogs. Biochemical assays of both rats and dogs included complete blood profiles, liver function tests, and renal function tests. For rat vitals, monitoring and histopathological analysis were also performed. Converted nanodroplets showed excellent contrast enhancement, better than Sonovue upon in vitro testing, with an enhancement time of up to 14 min. In vivo, experiments showed comparable opacification of the ventricles of both rats and dogs. All biochemical assays remained within the normal range during the study period. The histopathological analysis did not show any signs of drug-induced toxicity, showing the safety of these nanodroplets. Pre-PGS-PFP nanodroplets hold great potential for use in echocardiography and abdominal imaging in both human and veterinary applications after clinical trials.
Distinct dynamic connectivity profiles promote enhanced conscious perception of auditory stimuli
Authors: Türker Başak , Manasova Dragana , Béranger Benoît , Naccache Lionel , Sergent Claire , Sitt Jacobo D.
Published: July 2024

The neuroscience of consciousness aims to identify neural markers that distinguish brain dynamics in healthy individuals from those in unconscious conditions. Recent research has revealed that specific brain connectivity patterns correlate with conscious states and diminish with loss of consciousness. However, the contribution of these patterns to shaping conscious processing remains unclear. Our study investigates the functional significance of these neural dynamics by examining their impact on participants’ ability to process external information during wakefulness. Using fMRI recordings during an auditory detection task and rest, we show that ongoing dynamics are underpinned by brain patterns consistent with those identified in previous research. Detection of auditory stimuli at threshold is specifically improved when the connectivity pattern at stimulus presentation corresponds to patterns characteristic of conscious states. Conversely, the occurrence of these conscious state-associated patterns increases after detection, indicating a mutual influence between ongoing brain dynamics and conscious perception. Our findings suggest that certain brain configurations are more favorable to the conscious processing of external stimuli. Targeting these favorable patterns in patients with consciousness disorders may help identify windows of greater receptivity to the external world, guiding personalized treatments.
Erroneous predictive coding across brain hierarchies in a non-human primate model of autism spectrum disorder
Authors: Chao Zenas C. , Komatsu Misako , Matsumoto Madoka , Iijima Kazuki , Nakagaki Keiko , Ichinohe Noritaka
Published: July 2024

In autism spectrum disorder (ASD), atypical sensory experiences are often associated with irregularities in predictive coding, which proposes that the brain creates hierarchical sensory models via a bidirectional process of predictions and prediction errors. However, it remains unclear how these irregularities manifest across different functional hierarchies in the brain. To address this, we study a marmoset model of ASD induced by valproic acid (VPA) treatment. We record high-density electrocorticography (ECoG) during an auditory task with two layers of temporal control, and applied a quantitative model to quantify the integrity of predictive coding across two distinct hierarchies. Our results demonstrate a persistent pattern of sensory hypersensitivity and unstable predictions across two brain hierarchies in VPA-treated animals, and reveal the associated spatio-spectro-temporal neural signatures. Despite the regular occurrence of imprecise predictions in VPA-treated animals, we observe diverse configurations of underestimation or overestimation of sensory regularities within the hierarchies. Our results demonstrate the coexistence of the two primary Bayesian accounts of ASD: overly-precise sensory observations and weak prior beliefs, and offer a potential multi-layered biomarker for ASD, which could enhance our understanding of its diverse symptoms.
A type II phosphatidylinositol-4-kinase coordinates sorting of cargo polarizing by endocytic recycling
Authors: Kourkoulou Anezia , Martzoukou Olga , Fischer Reinhard , Amillis Sotiris
Published: July 2024

Depending on their phosphorylation status, derivatives of phosphatidylinositol play important roles in vesicle identity, recognition and intracellular trafficking processes. In eukaryotic cells, phosphatidylinositol-4 phosphate pools generated by specific kinases are key determinants of the conventional secretion pathways. Earlier work in yeast has classified phosphatidylinositol-4 kinases in two types, Stt4p and Pik1p belonging to type III and Lsb6p to type II, with distinct cellular localizations and functions. Eurotiomycetes appear to lack Pik1p homologues. In Aspergillus nidulans, unlike homologues in other fungi, AnLsb6 is associated to late Golgi membranes and when heterologously overexpressed, it compensates for the thermosensitive phenotype in a Saccharomyces cerevisiae pik1 mutant, whereas its depletion leads to disorganization of Golgi-associated PHOSBP-labelled membranes, that tend to aggregate dependent on functional Rab5 GTPases. Evidence provided herein, indicates that the single type II phosphatidylinositol-4 kinase AnLsb6 is the main contributor for decorating secretory vesicles with relevant phosphatidylinositol-phosphate species, which navigate essential cargoes following the route of apical polarization via endocytic recycling.
PUFFFIN: an ultra-bright, customisable, single-plasmid system for labelling cell neighbourhoods
Authors: Lebek Tamina , Malaguti Mattias , Boezio Giulia LM , Zoupi Lida , Briscoe James , Elfick Alistair , Lowell Sally
Published: July 2024

Cell communication coordinates developmental processes, maintains homeostasis, and contributes to disease. Therefore, understanding the relationship between cells in a shared environment is crucial. Here we introduce Positive Ultra-bright Fluorescent Fusion For Identifying Neighbours (PUFFFIN), a cell neighbour-labelling system based upon secretion and uptake of positively supercharged fluorescent protein s36GFP. We fused s36GFP to mNeonGreen or to a HaloTag, facilitating ultra-bright, sensitive, colour-of-choice labelling. Secretor cells transfer PUFFFIN to neighbours while retaining nuclear mCherry, making identification, isolation, and investigation of live neighbours straightforward. PUFFFIN can be delivered to cells, tissues, or embryos on a customisable single-plasmid construct composed of interchangeable components with the option to incorporate any transgene. This versatility enables the manipulation of cell properties, while simultaneously labelling surrounding cells, in cell culture or in vivo. We use PUFFFIN to ask whether pluripotent cells adjust the pace of differentiation to synchronise with their neighbours during exit from naïve pluripotency. PUFFFIN offers a simple, sensitive, customisable approach to profile non-cell-autonomous responses to natural or induced changes in cell identity or behaviour.
Role of advanced oxidation processes in lignocellulose pretreatment towards biorefinery applications: a review on emerging trends and economic considerations
Authors: Di Fraia Alessia , Di Fraia Simona , V Godvin Sharmila , Banu J Rajesh , Massarotti Nicola
Published: July 2024

Renewable energy sources have been recognized as a viable alternative to fossil fuels.
Recent advances for enhanced photodynamic therapy: from new mechanisms to innovative strategies
Authors: Wang Xia , Peng Jinlei , Meng Chi , Feng Fude
Published: July 2024

Photodynamic therapy (PDT) has been developed as a potential cancer treatment approach owing to its non-invasiveness, spatiotemporal control and limited side effects.
Insights into the terahertz response of l-glutamic acid and its receptor
Authors: Wu Yu , Zhu Zhongjie , Yang Jinrong , Wang Jie , Ji Te , Zhu Huachun , Peng Weiwei , Chen Min , Zhao Hongwei
Published: July 2024

THz reveals the interaction between l-Glu and the NMDAR involving water molecules.
Removal and detection of phenols through an SPE-HPLC method using microporous organic networks as adsorbent
Authors: Ali Azam , Sun Huipeng , Rizvi Syed Faheem Askari , Nana Ding , Zhang Haixia
Published: July 2024

A rational design and facile synthesis approach were used for the construction of novel magnetically separating MONs with the potential to efficiently adsorb polycyclic aromatic hydrocarbons in water samples.
A LAMP–CRISPR/Cas12b rapid detection platform for canine parvovirus detection
Authors: Chen Yuting , Zhang Xinyu , Hu Gui , Pan Yueying , Guan Yuhong , Yang Jinquan , Chen Hui
Published: July 2024

Canine parvovirus (CPV) is one of the main pathogens causing toxic diarrhea in Chinese dogs, is the cause of a large-scale epidemic of dogs, and poses a great threat to the dog industry in China.
The 3d–4f electron transition of the CoS2/CeO2 heterojunction for efficient oxygen evolution
Authors: Chen Yaqin , Zhang Yuchao , Xue Hui , Sun Jing , Guo Niankun , Song Tianshan , Sun Jiawen , Hao Yi-Ru , Wang Qin
Published: July 2024

Herein, a CoS2/CeO2 with superior OER activity is obtained, indicating that the d–p–f electron transport ladder can facilitate electron transfer through the Co–O(S)–Ce bond, optimize the adsorption free energy, and enhance catalytic activity.
Perphenazine modified pillar[5]arene based nano-assemblies for synergistic photothermal and photodynamic cancer therapy
Authors: Ma Longtao , Dai Yu , Meng Yujia , Yu Wenqiang , Bai Yiqiao , Cai Yan , Han Ying , Wang Jin , Yao Long , Yao Yong
Published: July 2024

Nano-assemblies based on perphenazine modified pillar[5]arene were constructed successfully for synergistic photothermal and photodynamic (I&II) cancer therapy.
Retarded sodium alloying interface reaction for stable anode-less sodium metal batteries
Authors: Wu Hao , Xie Chunlin , Zhang Mingze , Zou Jiapeng , Feng Runxin , Lu Hongqin , Zhang Qi , Tang Yougen , Wang Haiyan
Published: July 2024

The slow alloying kinetics between Pb and sodium allows for prolonged Pb retention in the coating, endowing the coating with a durable sodiophilicity.
Organophotocatalytic access to C-glycosides: multicomponent coupling reactions using glycosyl bromides
Authors: Sawada Naoya , Yu Ziyi , Takinami Hiryu , Inoue Daichi , Ghosh Titli , Sasaki Norihiko , Nokami Toshiki , Taniguchi Tsuyoshi , Abe Manabu , Koike Takashi
Published: July 2024

Photochemical multi-component coupling reactions initiated by the activation of glycosyl bromides in the presence of 1,4-bis(diphenylamino)benzene (BDB) as an organic photocatalyst were developed.
Metal-free, photoredox-catalyzed aromatization-driven deconstructive functionalization of spiro-dihydroquinazolinones with α-CF3 alkenes
Authors: Zhang Jin-Hua , Miao Hong-Jie , Li Jia-Yi , Li Wenke , Ma Pengchen , Duan Xin-Hua , Guo Li-Na
Published: July 2024

Metal-free, photoredox-catalyzed aromatization-driven deconstructive functionalization of spiro-dihydroquinazolinones with α-CF3 alkenes is achieved with high chemoselectivity. Mechanistic studies suggest a radical pathway for this cascade reaction.
Spectroscopic investigation of size-dependent CO2 binding on cationic copper clusters: analysis of the CO2 asymmetric stretch
Authors: Reider A. M. , Szalay M. , Reichegger J. , Barabás J. , Schmidt M. , Kappe M. , Höltzl T. , Scheier P. , Lushchikova O. V.
Published: July 2024

The asymmetric stretch vibration of CO2 on different Cun+ cluster sizes, with n = 1–10, is spectroscopically investigated. The strongest binding is found with Cu+, decreasing with cluster size, as reflected in the vibration frequency shift.
Rotational spectroscopy of 2,4,6-cycloheptatriene-1-carbonitrile: facilitating the search for complex cyclic molecules in the ISM
Authors: Batra Gayatri , Pille Laura , Arenas Benjamin E. , Schnell Melanie
Published: July 2024

Cycloheptratriene-1-carbonitrile represents a natural next step in the complexity of detected CN-substituted molecules in space. We provide a comprehensive rotational spectroscopy analysis to facilitate its detection in the interstellar medium.
Human-friendly semitransparent organic solar cells achieving high performance
Authors: Wu Zonghao , Shi Beibei , Yu Jiangsheng , Sha Mengzhen , Sun Jiangkai , Jiang Dongcheng , Liu Xin , Wu Wenxiao , Tan Yang , Li Huiyuan , Huang Shufen , Wang Jingjing , Liu Junwei , Zhang Chao , Ma Xiaoling , Cui Liyong , Ye Long , Zhang Fujun , Cao Bingqiang , Chen Yuguo , Ji Ziwu , Chen Feng , Hao Xiaotao , Li Gang , Yin Hang
Published: July 2024

We systematically evaluated the photobiological safety of mainstream ST-PV devices and fabricated a series of high-performance human-friendly ST-PV devices with LUE values exceeding 5.0% and low skin/eye damage levels for human beings.
Importance of the catalyst–water Coulomb interaction for oxygen reduction reaction kinetics
Authors: Liu Teng , Zhao Yinghe , Zhai Tianyou
Published: July 2024

This work identifies an important new factor affecting oxygen reduction reaction kinetics (i.e., the catalyst–water Coulomb interaction).
Correction: Emerging pollutants in the Esmeraldas watershed in Ecuador: discharge and attenuation of emerging organic pollutants along the San Pedro–Guayllabamba–Esmeraldas rivers
Authors: Voloshenko-Rossin A. , Gasser G. , Cohen K. , Gun J. , Cumbal-Flores L. , Parra-Morales W. , Sarabia F. , Ojeda F. , Lev O.
Published: July 2024

Correction for ‘Emerging pollutants in the Esmeraldas watershed in Ecuador: discharge and attenuation of emerging organic pollutants along the San Pedro–Guayllabamba–Esmeraldas rivers’ by A. Voloshenko-Rossin et al., Environ. Sci.: Processes Impacts, 2015, 17, 41–53, https://doi.org/10.1039/C4EM00394B.
Enhanced removal of As(iii) by manganese-doped defective UiO-66 coupled peroxymonosulfate: multiple reactive oxygen species and system stability
Authors: Xie Zihao , He Qingyun , Liu Shaobo , Huang Xinyi , Dai Mingyang , Chen Qiang , Sun Ang , Ye Jian , Tan Xiaofei , Xu Weihua
Published: July 2024

In this study, a Mn-doped defective UiO-66 was successfully synthesized. The catalyst/PMS system can efficiently remove As(iii) in wide pH and complex water environments.
A metal-free photocatalytically active hybrid fiber as a novel self-cleaning adsorbent for enhanced tetracycline removal
Authors: Ni Kaijie , Xu Ruiqi , Chen Yanlong , Guo Ming
Published: July 2024

A recyclable metal-free photocatalytically active hybrid fiber is fabricated, and presents a significantly photo-enhanced removal effect on tetracycline.
Assessing the undesired impacts on water sustainability from climate change mitigation technologies in fossil-based power generation
Authors: Moodley Prebantha , Harding Kevin , Adams Thomas A.
Published: July 2024

In the absence of water quality and water scarcity data, WICa provides meaningful results between carbon mitigation technologies. It is useful as a technology decision making tool, validated here by 6 technologies in fossil-based power generation.
Selective C(sp3)–H bond aerobic oxidation enabled by a π-conjugated small molecule-oxygen charge transfer state
Authors: Huang Panyi , Xu Yan , Song Haijing , Wang Jiayin , Wang Jiayang , Li Jianjun , Sun Bin , Jin Can
Published: July 2024

A π-conjugated small molecule-oxygen charge transfer state enables selective C(sp3)–H oxidation, avoiding the use of photocatalysts, metals, and redox reagents.
Catalyst-free synthesis of hydrazino-containing glycine derivatives via a diaziridine in situ formation/ring-opening cascade
Authors: Rong Chang-Long , Li Qiang-Qiang , Xuan Jun
Published: July 2024

A green and efficient method for the synthesis of glycine derivatives from amines, azodicarboxylates, and diazoalkanes has been developed. This multicomponent reaction occurred under mild conditions in the absence of any catalysts or additives.
A potential natural chalcopyrite reference material for in situ copper, iron, and sulfur isotope measurements
Authors: Xie Lie-Wen , Fan Hong-Rui , Yu Hui-Min , Huang Chao , Xu Lei , Yang Yue-Heng , Wu Shi-Tou , Wang Hao
Published: July 2024

A natural chalcopyrite sample, named IGGCcp-1, has undergone rigorous isotopic homogeneity testing and has been identified as a highly promising reference material for in situ micro-analysis of Cu–Fe–S isotopic compositions.
Electron beam lithography of GeTe through polymorphic phase transformation
Authors: Zhang Hu , Li Meng , Mi Shao-Bo , Cheng Shao-Dong , Lu Lu , Chen Zhi-Gang
Published: July 2024

An atomic-scale electron beam lithography technique is adopted to fabricate GeTe-based quantum devices compromising nanopillars or superlattices of c- and h-GeTe in α-GeTe.
Naphthalimides as anti-cancer agents: systematic synthesis and biological activity along with their encapsulated G0.5 PAMAM dendrimer nanoparticles
Authors: Noshirvani Sharifabad Azita , Khosravi Alireza , Shirazi Farshad H. , Shaki Hanieh , Farnam Golrokh , Moghimi Hamid Reza , Kobarfard Farzad
Published: July 2024

Fabrication of six novel naphthalimide derivatives encapsulated within G0.5 PAMAM dendrimer nanoparticles, exhibiting promising anticancer properties through a DNA intercalation mechanism attributed to the planar structure of naphthalimides.
Vanadium(v) arylimido alkylidene N-heterocyclic carbene complexes containing fluorinated alkoxide or halogenated phenoxide ligands for the syndiospecific ROMP of cyclic olefins
Authors: Nomura Kotohiro , Kuwahara Shuko , Suthala Jirapa , Kawamoto Yuta , Shimoyama Daisuke , Buchmeiser Michael R.
Published: July 2024

[V(N-2,6-Cl2C6H3)(CHSiMe3)(OC6X5)(NHC)] exhibited remarkable catalytic activities for ROMP of norbornene at 25 °C to afford ring-opened polymers not only with high cis-(93–98%) selectivity, but also with exclusive syndiotactic stereo-regularity.
The etiology, pathogenesis, treatment, and development of transdermal drug delivery systems for rheumatoid arthritis
Authors: Baig Mirza Muhammad Faran Ashraf , Kwan Chi Hin , Wu Hongkai , Chair Sek Ying
Published: July 2024

Rheumatoid arthritis (RA) is a long-term autoimmune disease that causes irreversible deformity of joints and disability of body parts. To avoid adverse effects of drugs the existing transdermal delivery techniques can be further developed or improved.
Blue light-emitting conjugated polymer with low modulus and better EL spectra stability
Authors: Gong Huaqiang , Huang Wenxin , Chen Wenyu , Bai Lubing , Liang Xinyu , Zheng Yingying , Lu Qingqing , Gao Rui , Han Yamin , Zhuo Zhiqiang , An Xiang , Lin Jinyi , Huang Wei
Published: July 2024

Investigated and optimized the intrinsic mechanical properties of polyfluorene-based conjugated polymers without sacrificing the optoelectronic properties by side-chain engineering.
Regulating photocatalysis by external-stimuli manipulation of the microenvironment in europium–organic frameworks
Authors: Lu Xin , Li Yi-Fan , Wang Chen-Li , Gao Jing-Yi , Zhou Yi , Zhang Chuan-Lei
Published: July 2024

Eu-MOF-T can transform into Eu-MOF-S under solvents. Eu-MOF-S can convert into Eu-MOF-T upon temperature. Eu-MOF-S demonstrates a superior photocatalytic CO2RR capacity of 7886.1 μmol g−1 h−1, Eu-MOF-T is only 599.7 μmol g−1 h−1.
Correction: Synthesis, docking and biological evaluation of purine-5-N-isosteres as anti-inflammatory agents
Authors: El-Saghier Ahmed M. , Enaili Souhaila S. , Abdou Aly , Hamed Amany M. , Kadry Asmaa M.
Published: July 2024

Correction for ‘Synthesis, docking and biological evaluation of purine-5-N-isosteres as anti-inflammatory agents’ by Ahmed M. El-Saghier et al., RSC Adv., 2024, 14, 17785–17800, https://doi.org/10.1039/D4RA02970D.
Hydroprocessing of biomass feedstock over sulfided CoMo-, NiMo-, and NiW-supported catalysts for bio-jet fuel component production: a review
Authors: Bukhtiyarova Marina V. , Vlasova Evgenia N. , Bukhtiyarova Galina A.
Published: July 2024

Recently, bio-jet fuels have attracted significant attention as a prospective additive to conventional aviation fuels since this is the most promising strategy to reduce CO2 emissions in the aviation sector in the future.
Low molar mass cyclic poly(l-lactide)s: separate transesterification reactions of cycles and linear chains in the solid state
Authors: Kricheldorf Hans R. , Weidner Steffen M.
Published: July 2024

l-Lactide (LA) was polymerized with neat tin(ii) 2-ethylhexanoate (SnOct2) in toluene at 115 °C at low concentration with variation of the LA/Cat ratio.
Methylene glycol-sulfite pH-clocks for the time-programming of soft materials: advantages, limitations, and yet unexplored opportunities
Authors: Panzarasa Guido
Published: July 2024

This Tutorial Review showcases methylene glycol-sulfite pH-clocks and their use for the time-programming of soft matter self-assembly and chemomechanical actuation.
Steroid sulfatase and sulfotransferases in the estrogen and androgen action of gynecological cancers: current status and perspectives
Authors: Rižner Tea Lanišnik , Gjorgoska Marija
Published: July 2024

Sulfatase (STS) and sulfotransferases (SULT) have important role in the biosynthesis and action of steroid hormones. STS catalyzes the hydrolysis of estrone-sulfate (E1-S) and dehydroepiandrosterone-sulfate (DHEA-S), while sulfotransferases catalyze the reverse reaction and require 3-phosphoadenosine-5-phosphosulfate as a sulfate donor. These enzymes control the concentration of active estrogens and androgens in peripheral tissues. Aberant expression of STS and SULT genes has been found in both, benign hormone-dependent diseases and hormone-dependent cancers. The aim of this review is to present the current knowledge on the role of STS and SULT in gynecological cancers, endometrial (EC) and ovarian cancer (OC). EC is the most common and OC the most lethal gynecological cancer. These cancers primarily affect postmenopausal women and therefore rely on the local production of steroid hormones from inactive precursors, either DHEA-S or E1-S. Following cellular uptake by organic anion transporting polypeptides (OATP) or organic anion transporters (OAT), STS and SULT regulate the formation of active estrogens and androgens, thus disturbed balance between STS and SULT can contribute to the onset and progression of cancer. The importance of these enzymes in peripheral estrogen biosynthesis has long been recognized, and this review provides new data on the important role of STS and SULT in the formation and action of androgens, their regulation and inhibition, and their potential as prognostic biomarkers.
The Collaboverse: A Collaborative Data-Sharing and Speech Analysis Platform
Authors: Dvorak Justin D. , Boutsen Frank R.
Published: July 2024

Purpose:

Collaboration in the field of speech-language pathology occurs across a variety of digital devices and can entail the usage of multiple software tools, systems, file formats, and even programming languages. Unfortunately, gaps between the laboratory, clinic, and classroom can emerge in part because of siloing of data and workflows, as well as the digital divide between users. The purpose of this tutorial is to present the Collaboverse, a web-based collaborative system that unifies these domains, and describe the application of this tool to common tasks in speech-language pathology. In addition, we demonstrate its utility in machine learning (ML) applications.

Method:

This tutorial outlines key concepts in the digital divide, data management, distributed computing, and ML. It introduces the Collaboverse workspace for researchers, clinicians, and educators in speech-language pathology who wish to improve their collaborative network and leverage advanced computation abilities. It also details an ML approach to prosodic analysis.

Conclusions:

The Collaboverse shows promise in narrowing the digital divide and is capable of generating clinically relevant data, specifically in the area of prosody, whose computational complexity has limited widespread analysis in research and clinic alike. In addition, it includes an augmentative and alternative communication app allowing visual, nontextual communication.
Overcoming the knowledge gaps in early‐stage servitization journey: A guide for small and medium enterprises
Authors: Rapaccini Mario , Adrodegari Federico , Pezzotta Giuditta , Saccani Nicola
Published: July 2024

Although the move to more service‐oriented business can be beneficial even to smaller firms, servitization in SMEs remains a largely unexplored topic. The authors contribute to fill this gap exploring how SMEs can overcome the knowledge gaps of servitization faced by companies in the early‐stages of this journey. By combining systematic literature review and expert panel methodology, the authors identify three knowledge gaps that hinder servitization initiatives in SMEs and propose a set of managerial recommendations to tackle with these gaps. In particular, the authors suggest a structured plan of recommendations, and point out how each stakeholder can contribute to fill the mentioned gaps. The proposed actions are specifically suggested for SMEs and focus on greater engagement of internal and external stakeholders. In addition to contributing to the domain scientific research on servitization, the authors therefore respond to the call for application‐oriented research.
Applying novel self‐supervised learning for early detection of retinopathy of prematurity
Authors: Wang Dongmei , Qiao Wanli , Guo Wei , Cai Yuansong
Published: July 2024

Retinopathy of prematurity (ROP) mainly occurs in premature infants with low birth weight, and it is the leading cause of childhood blindness. Early and accurate ROP diagnosis is imperative for appropriate treatment. However, less research concentrates on early‐stage ROP diagnosis based on limited‐labelled images in an imbalanced dataset. To address the dilemma, this study proposed a novel self‐supervised network, MOCO‐MIM, for early ROP grading. The proposed classification network was evaluated on a total of 553 labelled fundus images from 89 preterm infants. The trained network achieved a test accuracy of 98.29% and an AUC score of 97.6% for three stages of grading. The adopted method is verified that the proposed method can be detected early stages of ROP more efficiently and grade the severity more accurately based on limited‐labelled fundus images, which is superior to the existing state‐of‐the‐art methods.
Study on the terahertz domain dielectric relaxation response and mechanism of thermal‐oxidative aged cross‐linked polyethylene
Authors: Wang Mengqi , Wang Shihang , Li Xinyu , Feng Yang , Wang Jingran , Li Shengtao
Published: July 2024

To further study the thermal‐oxidative ageing mechanism of crosslinked polyethylene (XLPE), the terahertz frequency domain dielectric parameters and relaxation phenomena of thermal‐oxidative aged XLPE are analysed using terahertz time domain spectroscopy. It is found that the real part of the terahertz dielectric constant increases with the increase of thermal‐oxidative ageing duration, and the imaginary part shows an overall upward trend. Relaxation of the complex dielectric constant of the aged XLPE samples is obvious. Through the second‐order Cole–Cole equation fitting, it is found that there are two relaxation processes around 0.15 and 1.5 THz, and the relaxation strength gradually increases with the ageing time. To explain this phenomena, microstructure changes and crystallisation behaviours are characterised using Fourier transform infrared spectrum and differential scanning calorimetry, respectively. It is suggested that the two relaxations may be caused by elastic dipole polarisation originating from the angular deflection of polar groups and stretching rotation of hydrogen bond. In addition, by comparing the relaxation strength in different temperatures, the source of the relaxation process is further confirmed.
Safety monitoring method for powerline corridors based on single‐stage detector and visual matching
Authors: Li Jinheng , Zheng Hanbo , Liu Peng , Liang Yanshen , Shuang Feng , Huang Junjie
Published: July 2024

Effective monitoring and early warning of overhead power lines are critical for ensuring power supply stability and personnel safety. However, existing methods that rely solely on single vision or light detection and ranging (LiDAR) have limitations such as numerous invalid alarms, hardware equipment constraints, and lack of real‐time monitoring capabilities. This article proposes an intelligent monitoring method for safety distance of the powerline corridor based on heterogeneous sensor information. Firstly, an optimised single‐stage detector is designed to detect safety hazard objects. In the detector, the backbone network and the sample matching strategy are improved; in addition, the learning strategy is adjusted. Next, the pose transformation relationship is obtained through the visual matching of prior LiDAR information and images. The back projection transformation of 2D–3D is achieved according to the relationship. Finally, a monocular camera‐based end‐to‐end distance measurement scheme is proposed by combining 2D object information with coordinate transformation relationships. The scheme is applied to the distance measurements from hazard objects to powerlines. The experimental results show that the optimisation method improves the detection accuracy and reduces the computational complexity of the model. Also, case experiments with continuous frame data verify the effectiveness of the safety distance monitoring scheme.
Measures to prevent the spread of non-infected bronchionecrosis, protozoan and lerniosis in fish
Authors: Yunusov Khudaynazar , Kurbanov Feruz , Yuldashev Xojiakbar , Achilov Odil , Ergashev Najmiddin , Muxammadiyev O’tkirxon
Published: July 2024

In general, the main cause of non-infectious bronchonecrosis in fish is recognized to be chronic exposure to unfavorable environmental factors on fish. White carp - 20.0%, eel - 14.6%. The infestation of all three fish species by crustaceans was found to be on average 19.3%. According to the results of the analysis, 18.0% of crustaceans in four districts of the Samarkand region were infected with 2 types: lerniosis, 1.3% - arguliosis.
The influence of agricultural biologization means on the content of essential amino acids in winter wheat grain
Authors: Zanilov Amiran , Leshkenov Aslan , Utkin Alexey
Published: July 2024

The effect of biological soil activation against the background of mineral and organic fertilizers (green manure) on the content of essential amino acids in winter wheat grain was studied. The technique is a pre- sowing application of a consortium of microorganisms (Pseudomonas fluoreiscence, strain AP-33, Azotobacter vinelandii IB-4) and microscopic fungi (Trichoderma harzianum and Trichoderma viridae) using a boom sprayer. It was found that the application of green manure and mineral fertilizers to non-activated soil is accompanied by a decrease in the amount of essential amino acids by 15.7 and 15.6%, respectively, in variants without mineral fertilizers and with ½ of their calculated dose. It has been established that the use of biological soil activation with the incorporation of green manure helps to increase the concentration of essential amino acids in variants with doses of mineral fertilizers 0 NPK and ½ NPK by 8.8 and 14.9%, respectively. An idea has been formed about the role of soil biological activity as a factor influencing not only the quality of agricultural products, but also a factor limiting the level of its productivity. Thus, it was found that the use of soil bioactivation helps to increase the yield of winter wheat by 11.7-17.7%, depending on the type of experiment.
The bioindicator properties of oribatid mites in soil fauna of Kashkadarya region
Authors: Majidova D.Z. , Mamarakhimov O.M. , Makhmudova M.M. , Turdalieva Kh.S. , Shamuratova N.T.
Published: July 2024

This article discusses the loss of bioindicator characteristics in oribatid mites found in the Kashkadarya region due to various anthropogenic and environmental factors. The study, conducted during the spring and summer of 2023, focused on pine and spruce gardens surrounding the Shortan gas-chemical industrial area. The results of our research identified 23 species, including Ornithonyssus bursa, Geratoppia quadridentate, Furcoribula furcillata, Perlohmannia altaica, Liochthonius kirghisicus, Asiacarius elongatus, Liochthonius hystricinus, Cultroribula dentata, Epilohmannia cylindrica and Michelia paradoxa with bioindicator properties. Changes in these indicators of species primarily occurred in the A soil layer, up to 10 cm deep. The study found that the primary factor influencing these changes was not the chemical waste from the industrial plant but rather acid gases resulting from burning companion gases, leading to acid rain formation when mixed with precipitation.
Determinants of rice harvest allocation choices in several agroecosystems of Indonesia
Authors: Yofa Rangga D. , Azis Miftahul , Setyaningrum Widyadhari F. , Susilowati Sri H. , Purwantini Tri B.
Published: July 2024

The volume of grain supply from rice farming traded in the market determines rice price fluctuations. Information on farmers’ behaviour in utilising rice harvests is strategic for knowing the volume of rice traded. This study analyses patterns and factors influencing farmers’ behaviour using rice harvests. Primary data from the National Farmer Panel (PATANAS) were processed using quantitative methods with econometric models (multiple regression and double hurdle models). The results show that direct grain sales after harvest occur more often in irrigated and tidal rice agroecosystems. Meanwhile, indirect sales of harvested grain occur more frequently in lowland swamp agroecosystems and in rain-fed rice fields. The grain that is not sold immediately is allocated for household consumption and seed purposes and sold in stages. Factors that indirectly influence grain sales are the price of rice, the area cultivated, and the type of agroecosystem. When rice prices rise, farmers reduce the amount of grain they sell directly. The recommended policy recommendations are efforts to increase production in all agroecosystems and stabilise rice prices by strengthening government rice reserves, considering that not all harvested grain is traded.
Strategies for achieving targeted Indonesian rice self-sufficiency: A comprehensive policy analysis
Authors: Prayuginingsih Henik , Hariyati Yuli , Aji Joni M.M. , Rondhi Mohammad , Muhtadi Kamil
Published: July 2024

Attaining self-sufficiency in rice production is paramount to Indonesia’s food security and economic independence. This study attempts to formulate a national alternative policy to achieve a Self-Sufficiency Ratio (SSR) of 97.8% for Indonesia. Drawing on data sourced from reputable institutions spanning the years 1998 to 2018, we propose econometric models, which are subsequently analysed using Two-Stage Least Square (2 SLS) methodology. The study’s findings highlight three critical strategies for achieving a 97.8% SSR in rice production: (a) focus on maximising productivity gains, (b) emphasise a balanced approach through expanding irrigated areas and enhancing productivity, and (c) advocate for a comprehensive approach involving increased irrigated areas, heightened productivity, and stricter import tariffs.
Exploring the potential of Indonesia rice germplasm collection to support its utilisation
Authors: Hidayatun Nurul , Risliawati Andari , Chaerani  , Yuriah Siti , Galurina Rina S. , Koswanudin Dodin
Published: July 2024

Indonesia is rich in rice germplasm that has the potential to support sustainable agriculture through a variety of development programs. This germplasm must be explored for its superior characteristics to be used optimally. This paper presents the efforts to explore the characters and genetic potentials of Indonesian rice germplasm collected at the Agricultural Genebank. Data were extracted from research reports from 2016−2022. Some rice accessions were characterised and evaluated through the characterisation and evaluation program. Of the 3,335 rice accessions managed by the Agricultural Genebank, 706 have been observed for their morpho-agronomic characteristics, 960 for molecular characteristics, and 113 for functional qualities. Resistance to biotic and abiotic stresses was evaluated in 700 and 250 accessions, respectively. A large number of data points have been generated. These valuable data were recorded, reported, and safely archived. Recommendations to address the remaining challenges and optimise germplasm utilisation are 1) expanding the characterisation-evaluation program to the whole collection and 2) developing an updated, communicative, and user-friendly information system to disseminate and facilitate the utilisation of rice germplasm collections. This study is useful for getting a comprehensive overview of germplasm management and setting further strategies for more efficient germplasm management.
Predicting national rice production 2023−2024 under rising food and energy prices and global climate change
Authors: Setiyanto Adi , Suryadi Muhammad , Azis Miftahul , Effendi Mohammad W.
Published: July 2024

The history of the food crisis since the 1990s shows that cycles and prolonged spikes in food and energy prices and climate changes have negatively impacted food production. This study aims to predict the impact of rising food and energy prices and global climate change on rice production in 2023 and 2024 at national and provincial levels. The structural vector autoregression (SVAR) analysis data from January 1993 to December 2022 from various national and international sources was used to measure the impact on a national level, and the shift-share analysis (SSA) approach was used for the rice sampling framework analysis to map the impact on provincial levels. Indonesia’s rice production is predicted to decrease by 3.16% and 3.75% in 2023 and 2024 compared to 2022. Analysis by province shows a decrease in almost all major rice-producing regions in Indonesia. This study suggests that the government (1) increase rice productivity in 16 provinces and increase both rice harvest area and productivity in 9 provinces and (2) coordinate with other ministries and institutions at central and regional levels to map regencies that have the opportunity to immediately increase production, ensure and increase the availability of input, infrastructure, facilities, and anticipate pest outbreaks.
Households rice demand in East Kalimantan: A QUAIDS approach
Authors: Cahyono Tri W. , Tokuda Hiromi , Waryanto Budi
Published: July 2024

As the new capital of Indonesia, East Kalimantan will drive population growth and increase demand for food (rice). Regarding food security, it is necessary to understand the economic and demographic factors that influence the demand for rice. SUSENAS 2021 data from BPS-Statistics Indonesia were used to analyse the impact of economic and demographic variables on rice consumption by including goods considered substitutes for rice as additional variables. The Quadratic Almost Ideal Demand System is employed to estimate the demand function and examine the effects of price, income, and demographic variables on seven food groups, including rice, maize, wheat, cassava, sweet potatoes, potatoes, instant noodles, and processed food. The study finds that increased household income leads to increased demand for all types of food and that rice consumption is more elastic in rural areas than in urban areas. Rice is income elastic for low-income households working in agriculture but is inelastic for other sectors and middle-high income. Maize and potatoes can be substituted for rice according to the cross-price elasticity, and rice is an independent good that is not affected by the prices of other goods. The government can reduce household rice consumption by increasing income and encouraging higher education.
Financial feasibility of developing early-stage organic rice farming: A case study in Tasikmalaya of Indonesia
Authors: Susilowati Sri H. , Swastika Dewa K. S. , Sudaryanto Tahlim , Hasibuan Abdul M. , Agustian Adang , Tarigan Herlina , Dermoredjo Saktyanu K. , Permana Dadan
Published: July 2024

Intensive rice farming using inorganic fertilisers creates the problem of soil fertility degradation and further impacts decreasing rice productivity. Alternative technologies are needed to increase production while maintaining the sustainability of agricultural resources through organic rice farming. This study aims to 1) analyse the financial feasibility of organic rice farming, 2) identify the constraints in developing organic rice farming, and 3) formulate an alternative policy to develop organic rice farming in Tasikmalaya, Indonesia. The primary data were collected from 30 organic rice farmers. Traditional rice farmer’s groups were also interviewed for comparison. The financial feasibility was analysed using cost and benefit analysis. The results showed that organic rice in Tasikmalaya is financially profitable, with the R/C ratios ranging from 1.14 to 1.45. However, the profit is still much lower than traditional rice farming. The main constraint to increasing organic rice profit is that the price of organic rice grain is not different from traditional rice since marketing institutions have not yet been established. To increase the profit of organic rice farming, the government should encourage farmers to keep growing organic rice, accompanied by technical guidance and establishment of organic rice processing and marketing institutions.
Assessment of the impact of agriculture on the regional socio-economic development
Authors: Xolmurotov F. S. , Xolmuratov Xolilla S. , Yakubova Yulduz R.
Published: July 2024

This article analyzed the impact of agriculture on the regional economy, population employment and export potential. Studies show that the volume of agricultural production and its export has a significant impact on the region's gross regional product, employment and income. Also, the study shows that the coefficient of elasticity of the volume of agricultural products is high, and the development of agriculture has a significant impact on the growth of the regional economy. In addition, the article emphasized the importance of developing agriculture-related industries and services for sustainable growth. In the article, regression and correlation analyzes were used to determine the relationship between agriculture and other economic indicators.
Application of green technologies in modern agriculture
Authors: Kievtsov Sergey
Published: July 2024

This study explores the key groups of green technologies applicable in modern agriculture, their functional roles, and potential centers for cooperation and testing in regional university laboratories. In the Russian Federation, the adoption of green technologies is crucial for agricultural producers to reorient towards modern methods, automate processes, and increase high-tech usage. The future of green technologies lies in their contribution to rural area development and preservation of local production processes. As a vital sector in the Kursk region, even a small increase in efficiency through green technology adoption can ensure the region's sustainability due to its significant scale.
Combined effects of deltamethrin and T-2 toxin on animals during the use of bentonite
Authors: Egorov Vladislav , Valiullin Lenar , Raginov Ivan , Alekseyko Leonid , Klimovich Sergey , Pamirsky Igor , Zakharenko Alexander , Yampolsky İlya , Golokhvast Kirill
Published: July 2024

This study investigated the combined effects of deltamethrin and T-2 toxin on animals, utilizing bentonite as a prophylactic agent. The research was conducted on white rats, which were orally administered the toxins for 20 consecutive days. Subsequently, clinical, hematological, and biochemical parameters were examined to assess the impact of the toxins on the animals. Based on research results, it has been established that the combined effect of deltamethrin and T-2 toxin with repeated administration is characterized by more severe clinical, hematological and biochemical changes than with separate exposure to toxicants. Accompanied by a decrease in the number of leukocytes, erythrocytes and hemoglobin, a decrease in total protein, glucose and cholinesterase activity. Adding bentonite to the feed as a prophylactic agent at a dose of 2% of the diet has a preventive effect in case of combined poisoning with deltamethrin and T- 2 toxin, and helps to normalize the clinical, hematological and biochemical parameters of animals.