bluuebunny/crossref_metadata_2025 huggingface dataset:
Write and Let Go: An Online Writing Program for University Students
Authors: Batista João , Marinai Janine C. , Gouveia Melissa , Oliveira João Tiago , Gonçalves Miguel M.
Published: July 2022

Background

There are a plethora of studies on expressive writing and positive writing interventions, but few have addressed the combination of both paradigms. Additionally, research on the role of ambivalence toward change in the context of writing-based interventions is lacking. Ambivalence toward change is a natural movement of approaching and avoiding change that may occur in various situations. In psychotherapy, its resolution is associated with successful outcomes.

Aim

This study tested the efficacy of a combination of expressive and positive writing paradigms in an internet-based intervention to improve university students’ mental health. Additionally, focusing participants on a current, unresolved problem allowed us to explore the possible role of ambivalence toward change as a mediator of the intervention’s results.

Methods

We recruited 172 participants who were randomly divided into experimental (n = 85) and control (n = 87) groups. The intervention consisted of the identification of a current problem and four writing tasks on consecutive days. Assessment was conducted at baseline and posttest in both groups and at follow-up in the experimental group. Participants in the experimental condition were also assessed after each task. Measures of anxiety, depression, rumination, ambivalence toward change, distress, and wellbeing (optimism, affect, and satisfaction with life) were collected.

Results

Multivariate analysis of variance (MANOVA) showed that participants in the experimental group had a significant decrease from baseline to posttest in ambivalence toward change and rumination when compared with the control group. These results were maintained at follow-up. No differences were found in the remaining measures. Within the experimental group, ambivalence toward change, rumination, and distress significantly decreased throughout the intervention and the exploratory mediation analysis indicated that ambivalence toward change partially mediated the improvements in rumination and distress.

Discussion

Considering different perspectives about a current problem and using a combination of expressive and positive writing fostered the reduction of ambivalence toward change and rumination. Ambivalence toward change reduction after the second writing task may have created optimal conditions for the subsequent decrease in rumination and distress. Future studies should replicate this finding and dismantle the components that are more adequate in changing these variables.
Affective States During the First Wave of the COVID-19 Pandemic: Progression of Intensity and Relation With Public Health Compliance Behavior
Authors: Leblanc-Sirois Yanick , Gagnon Marie-Ève , Blanchette Isabelle
Published: July 2022

The COVID-19 pandemic was expected to cause intense affective reactions. This situation provided a unique opportunity to examine the characteristics and correlates of emotions in a real-world context with great significance. Our study aimed to describe the progression of positive and negative affective states during the pandemic, and to investigate which affective states predicted compliance with public health measures. We undertook a survey of affective states in the province of Quebec at the beginning, the peak, and the aftermath of the first wave of the COVID-19 pandemic. We recruited 530 responders; 154 responded to all three surveys. We used self-report scales to measure affective states and compliance with public health measures. We then computed separate linear regressions for the three phases of our study, with compliance with health measures as the dependent variable. Affective states were generally most intense at the beginning of the pandemic. Fear-related pandemic-related affective states reliably predicted compliance with public health measures in the three phases of our study. Positively valenced affective states related to the societal response also contributed predictive value, but only at the peak of the first wave.
Inclusive Leadership and Employees’ Helping Behaviors: Role of Psychological Factors
Authors: Qasim Samina , Usman Muhammad , Ghani Usman , Khan Kalimullah
Published: July 2022

Based on social learning theory, the present study investigates the influence of inclusive leadership on employees’ helping behaviors. Further, psychological mechanisms (psychological safety and psychological engagement) are investigated in the relationship between inclusive leadership and employees’ helping behaviors. The data was collected in three time-lags through a questionnaire from 409 nurses working in the health sector of Pakistan. The collected data was analyzed through IBM-SPSS and AMOS to test the proposed model. The study’s findings show that inclusive leadership positively influences employees helping behaviors. Moreover, the psychological factors (i.e., safety and engagement) mediate the relationship between inclusive leadership and employees’ helping behaviors. Theoretical and practical implications for managers, practitioners, and organizations are discussed, while study limitations and directions for future research are also highlighted.
How Emotion Relates to Language and Cognition, Seen Through the Lens of Evaluative Priming Paradigms
Authors: Rohr Michaela , Wentura Dirk
Published: July 2022

Affect and emotion are essential aspects of human life. These states or feelings signal personally relevant things or situations and color our memories and thoughts. Within the area of affective or emotion processing, evaluation–the assessment of the valence associated with a stimulus or event (i.e., its positivity or negativity)–is considered a fundamental process, representing an early and crucial stage in constructivist emotion theories. Valence evaluation is assumed to occur automatically when encountering a stimulus. But does this really apply always, even if we simply see a word? And if so, what exactly is processed or activated in memory? One approach to investigating this evaluative process uses behavioral priming paradigms and, first and foremost, the evaluative priming paradigm and its variants. In the present review, we delineate the insights gained from this paradigm about the relation of affect and emotion to cognition and language. Specifically, we reviewed the empirical evidence base with regard to this issue as well as the proposed theoretical models of valence evaluation, specifically with regard to the nature of the representations activatedviasuch paradigms. It will become clear that affect and emotion are foremost (and, perhaps, even exclusively) triggered by evaluative priming paradigms in the sense that semantic affective knowledge is activated. This knowledge should be modeled as being active in working memory rather than in long-term memory as was assumed in former models. The emerging evidence concerning the processing of more specific emotion aspects gives rise to the assumption that the activation of these semantic aspects is related to their social importance. In that sense, the fast and (conditionally) automatic activation of valence and other emotion aspects in evaluative priming paradigms reveals something about affect and emotion: Valence and specific emotion aspects are so important for our daily life that encountering almost any stimulus entails the automatic activation of the associated valence and other emotion aspects in memory, when the context requires it.
The Construction of Ecosystem and Collaboration Platform for Enterprise Open Innovation
Authors: Wang Maoxiang , Zhang Ruili , Abdulwase Rasheed , Yan Shuangsheng , Muhammad Mohsin
Published: July 2022

In the era of the knowledge economy that is filled with intense competition, formal closed innovation can no longer meet the market demand. The enterprise needs to implement open innovation involving external resources. The concept of open innovation emphasizes both the use of internal and external resources in the process of enterprise innovation and the use of internal and external markets to promote the commercial application of innovation achievements. With the rapid development of Internet technology, enterprises must build an open innovation ecosystem of benefits-sharing, identify, connect, and utilize external innovation resources, and be committed to creating an open innovation ecosystem without organizational boundaries. Enterprises should pay attention to coordinating the relationships among the innovation ecosystem members, eliminating heterogeneous barriers between enterprises and their partners, and enhancing their cooperative innovation ability with external organizations. It is also necessary to build a collaborative innovation platform convenient for the release and acquisition of innovation information, the collection of customer needs and related ideas, and the full use of external resources for innovation. In particular, it is necessary to guide users and related resources to the innovation platform, realize the maximum effect of resource aggregation, and promote customer demand-oriented new product development. Through building an open innovation ecosystem and a collaboration platform, it is helpful for enterprises to seek all kinds of technical and resource support, enhance their ability of independent innovation, promote the emergence of many innovative achievements, and realize value co-creation and win-win cooperation with partners.
Trait Anxiety Mediates Impulsivity and Suicidal Ideation in Depression During COVID-19 Pandemic
Authors: Cheng Xinyu , Zhang Yi , Zhao Di , Yuan Ti-Fei , Qiu Jianyin
Published: July 2022

Suicidality in patients with major depressive disorder (MDD) has been an urgent affair during the COVID-19 pandemic. It is well-established that impulsivity and trait anxiety are two risk factors for suicidal ideation. However, literature is still insufficient on the relationships among impulsivity, (state/trait) anxiety and suicidal ideation in individuals with MDD. The present study aims to explore the relationships of these three variables in MDD patients during the COVID-19 pandemic through three scales, including Barrett Impulsivity Scale (BIS), State-Trait Anxiety Scale (STAI) and Self-rating Idea of Suicide Scale (SIOSS). Sixty-three MDD patients (low SIOSS group and high SIOSS group, which were split by the mean score of SIOSS) and twenty-seven well-matched healthy controls were analyzed. Our results showed that the high SIOSS group had higher trait anxiety (p < 0.001, 95% CI = [−19.29, −5.02]) but there was no difference in state anxiety (p = 0.171, 95% CI = [−10.60, 1.25]), compared with the low SIOSS group. And the correlation between impulsivity and suicidal ideation was significant in MDD patients (r = 0.389, p = 0.002), yet it was not significant in healthy controls (r = 0.285, p = 0.167). Further, mediation analysis showed that trait anxiety significantly mediate impulsivity and suicidal ideation in patients with depression (total effect: β = 0.304, p = 0.002, 95% CI = [0.120, 0.489]; direct effect: β = 0.154, p = 0.076, 95% CI = [−0.169, 0.325]), indicating impulsivity influenced suicidal ideation through trait anxiety in MDD patients. In conclusion, our results suggested that trait anxiety might mediate the association of impulsivity and suicidal ideation in MDD patients. Clinicians may use symptoms of trait anxiety and impulsivity for screening when actively evaluating suicidal ideation in MDD patients, especially in the setting of COVID-19 pandemic.
Brain Stimulation and Group Therapy to Improve Gesture and Social Skills in Schizophrenia—The Study Protocol of a Randomized, Sham-Controlled, Three-Arm, Double-Blind Trial
Authors: Chapellier Victoria , Pavlidou Anastasia , Mueller Daniel R. , Walther Sebastian
Published: July 2022

An important component of nonverbal communication is gesture performance, which is strongly impaired in 2/3 of patients with schizophrenia. Gesture deficits in schizophrenia are linked to poor social functioning and reduced quality of life. Therefore, interventions that can help alleviate these deficits in schizophrenia are crucial. Here, we describe an ongoing randomized, double-blind 3-arm, sham-controlled trial that combines two interventions to reduce gesture deficits in schizophrenia patients. The combined interventions are continuous theta burst stimulation (cTBS) and social cognitive remediation therapy (SCRT). We will randomize 72 patients with schizophrenia spectrum disorders in three different groups of 24 patients. The first group will receive real cTBS and real SCRT, the second group will receive sham cTBS and real SCRT, and finally the third group will receive sham SCRT. Here, the sham treatments are, as per definition, inactive interventions that mimic as closely as possible the real treatments (similar to placebo). In addition, 24 age- and gender-matched controls with no interventions will be added for comparison. Measures of nonverbal communication, social cognition, and multimodal brain imaging will be applied at baseline and after intervention. The main research aim of this project will be to test whether the combination of cTBS and SCRT improves gesture performance and social functioning in schizophrenia patients more than standalone cTBS, SCRT or sham psychotherapy. We hypothesize that the patient group receiving the combined interventions will be superior in improving gesture performance.

Clinical Trial Registration

[www.ClinicalTrials.gov], identifier [NCT04106427].
The Interplay Between Poor Sleep and Work-Related Health
Authors: Fietze Ingo , Rosenblum Lisa , Salanitro Matthew , Ibatov Alexey Danilovich , Eliseeva Marina Vladimirovna , Penzel Thomas , Brand Désirée , Westermayer Gerhard
Published: July 2022

Objectives

Sleep disorders can arise from work. Employees who experience work overload are more likely to develop sleep problems. Poor sleep leads to decreased performance, sick leave, and accidents. Therefore, sleep disorders may be linked to workplace hazards as well as decreased occupational health, however, the relationship remains unknown.

Methods

This relationship was examined using secondary data analysis of aggregated survey data from 97 companies based in Germany between 2003 and 2020 as part of Workplace Health Management project. Two extreme groups with respect to sleep problems were analyzed (N = 4,865 + 9,795). The survey “Diagnosis of corporate health” contained 137 individual questions which recorded all relevant working conditions, aspects of health, and one question relating to insomnia traits. A one-way analysis of variance was used to examine whether and to what extent the potentials, hazards, and health aspects differed between employees depending on their perceived sleep problems. In addition, multiple linear regressions were used to determine whether and to what extent work characteristics affect various health aspects for both good and poor sleepers.

Results

In total, 49.7% of staff reported moderate difficulty falling and/or remaining asleep. These poor sleepers perceived all health potentials worse than good sleepers, especially on scales such as fair assessment, work climate, and learning at work. Furthermore, poor sleepers perceived health hazards (physical environmental stress, job insecurity, and time pressure) more whilst positive health indicators (joy of work and confidence) were perceived less.

Conclusion

Overall, the determination of sleep difficulties could be used as a substantial health indicator. Also, these sleep problems are reported more frequently in certain occupations compared to others, which could mean that the perception of sleep health varies between professions. Therefore, it is important to implement specific recommendations for each industry in order to improve working conditions for poor sleepers which in turn, improves their health.
Stressful Life Events and Chronic Fatigue Among Chinese Government Employees: A Population-Based Cohort Study
Authors: Qiu Dan , He Jun , Li Yilu , Li Ruiqi , Ouyang Feiyun , Li Ling , Luo Dan , Xiao Shuiyuan
Published: July 2022

Background

Currently, evidence on the role of stressful life events in fatigue among the Chinese working adults is lacking. This study aimed at exploring the prospective associations between stressful life events and chronic fatigue among Chinese government employees.

Methods

From January 2018 to December 2019, a total of 16206 government employees were included at baseline and they were followed-up until May 2021. A digital self-reported questionnaire platform was established to collect information on participants' health and covariates. Life events were assessed by the Life Events Scale (LES), fatigue was assessed by using a single item, measuring the frequency of its occurrence. Binary logistic regression analysis was used for the data analysis.

Results

Of the included 16206 Chinese government employees at baseline, 60.45% reported that they experienced negative stressful life events and 43.87% reported that they experienced positive stressful life events over the past year. Fatigue was reported by 7.74% of the sample at baseline and 8.19% at follow-up. Cumulative number of life events at baseline, and cumulative life events severity score at baseline were positively associated with self-reported fatigue at follow up, respectively. After adjusting sociodemographic factors, occupational factors and health behavior related factors, negative life events at baseline (OR: 2.06, 95% CI: 1.69–2.51) were significantly associated with self-reported fatigue at follow-up. Some specific life events including events related to work and events related to economic problems were significantly associated with self-reported fatigue. Specifically, work stress (OR = 1.76, 95%CI: 1.45–2.13), as well as not satisfied with the current job (OR = 1.95, 95%CI: 1.58–2.40), in debt (OR = 1.75, 95%CI: 1.40–2.17) were significantly associated with self-reported fatigue. The economic situation has improved significantly (OR = 0.62, 95%CI: 0.46–0.85) at baseline was significantly associated with lower incidence of self-reported fatigue.

Conclusion

Negative stressful life events were associated with fatigue among Chinese government employees. Effective interventions should be provided to employees who have experienced negative stressful life events.
An Assessment Framework for the Training of General Practitioners and Specialists Based on EPAs
Authors: Gao Shenshen , Li Na , Wang Xinqiong , Yu Yi , Zhao Ren , Trigo Virgínia , Ramalho Nelson Campos
Published: July 2022

Purpose

The purpose of this study is to explore the practicality and feasibility of EPA (level 4 theory) for establishing medical training and service model in China.

Method

We opted for a mixed qualitative and quantitative research method, considering both explanatory and exploratory sequential designs. The qualitative research comprehended focus groups and interviews conducted with two panels of experts. The quantitative research was conducted to collect data about the applicability of international entrustable professional activities (EPAs) pediatrics standards in the Chinese context by organizing a seminar with a sample of 60 pediatricians. A questionnaire was designed with EPAs and distributed within professional networks. Structural equation modeling and statistical analysis were used to process the data.

Results

In this study, Medical Service-Groups Model (MSGM) with four levels was successfully established to measure the correlation between specialized and general EPAs. As expected, results showed that specialized EPAs were built on top of general EPAs. There may be a mediating mechanism that general EPAs contribute to the lower level of specialization EPAs. In addition, levels 1 and 2 were primarily needed to lay the groundwork for levels 3 and 4, and these higher levels of EPAs were still the most informative for specialized Gastroenterology EPAs.

Conclusions

The diagnosis and treatment level of primary general practitioners, as the basis of the pediatric medical service chain, affected the clinical disposal ability of specialists. The establishment of MSGM provided a theoretical basis for the linkage training of general practitioners and specialist physicians. In future studies, scholars must explore China's EPAs based on unique national conditions.
Afternoon Napping Durations in Chinese Population Over 60 Years Old: Longitudinal Associations With Cognitive Performance
Authors: Li Chao , Yan Yan
Published: July 2022

Introduction

Previous studies indicated inconsistent associations between daytime napping and cognitive decline. This study aimed to examine the associations between self-reported changes in napping and longitudinal cognitive performance.

Methods

A national representative sample of 4,024 participants over 60 was obtained from the China Health and Retirement Longitudinal Study from 2011 to 2018. Afternoon napping and potential factors were collected by a questionnaire. Cognitive performance was assessed on three aspects. The generalized additive models and generalized estimating equations were used to examine relationships between daytime napping and longitudinal global cognition, and generalized linear models were used to examine the longitudinal associations between change in napping at four waves and cognition in wave 4.

Results

After controlling the potential confounders, participants with afternoon napping were significantly related to better global cognition than no nappers at baseline. A change from short napping to no/long napping was associated with worse cognitive performance (β = −2.593, P < 0.001). A move from no napping to short/long napping was also associated with lower cognition scores (β = −0.694, P < 0.001). For participants with moderate napping, a >30 min increase (β = −1.558, P < 0.001) in afternoon napping was associated with worse cognitive function in wave 4.

Conclusion

We observed that adults over 60 years old with napping <30 min per day may be at lower risk of cognitive decline. Change in napping, especially a move to extreme napping would be a risk marker underlying health conditions that impact cognition or go along with cognitive decline.
Causes of Death in Long-Term Nasopharyngeal Carcinoma Survivors
Authors: Yang Shi-Ping , Rao Ming-Yue , Chen Qing-Shuang , Zhou Ping , Lian Chen-Lu , Wu San-Gang
Published: July 2022

Purpose

To assess the causes of death (COD) and long-term survival after nasopharyngeal carcinoma (NPC) diagnosis.

Methods

Using linked data from the Surveillance, Epidemiology, and End Results program, patients with NPC diagnosed from 1990 to 2010 and followed up >5 years were identified. Chi-squared test, the Kaplan–Meier method, and the Cox proportional hazard model were used for analyses.

Results

Among the 3,036 long-term NPC survivors, 1,432 survived for >5–10 years and 1,604 survived for >10 years. The most common COD was primary NPC (36.9%), followed by other causes (28.7%), other cancers (15.3%), cardiac disease (12.9%), and non-malignant pulmonary disease (6.2%). With a median follow-up of 125 months, deaths from NPC decreased with increasing time from diagnosis, while death because of cardiac disease and other causes increased. In those aged <50 years, death due to NPC remained the main COD over time, while cardiopulmonary disease-related death was the leading COD in patients aged ≥50 years. In White patients, death due to NPC decreased, and death due to cardiac disease increased over time. Death from NPC remained significant in Black and Asian patients even 15 years after the diagnosis of NPC, while death due to cardiac disease significantly increased after 9 years of diagnosis in Black patients. Multivariate analyses showed that the independent factors associated with inferior NPC-specific survival were older age, Asians, American Indian/Alaska Native, regional stage, distant stage, and diagnosis in the early years.

Conclusions

The probability of death from primary NPC remains significant even 15 years after the NPC diagnosis. Our study advocates continued surveillance for NPC survivors beyond the traditional 5 years. Individualized follow-up strategies are required for patients with NPC of different ages and races.
Knowledge, Attitudes, and Practices Regarding “New Normal” Guidelines and Quality of Life Among Thai People During the COVID-19 Outbreak: An Online Cross-Sectional Survey
Authors: Waewwab Pathavee , Pan-ngum Wirichada , Siri Sukhontha , Bhopdhornangkul Bhophkrit , Mahikul Wiriya
Published: July 2022

In Thailand, strict prevention and control strategies have been implemented to mitigate the rapid spread of coronavirus disease 2019 (COVID-19). “New normal” guidelines and a series of mobile health applications have been introduced by the healthcare sector and implemented to aid the disease control monitoring and prevention of widespread outbreaks. This study aimed to assess the knowledge, attitudes, and practices (KAP) regarding “new normal” guidelines and quality of life (QOL) among Thai people during the COVID-19 outbreak, and to determine the association between KA, QOL, and practices. An online cross-sectional survey was conducted from 7 June to 12 September 2021 among Thai people in Public Health Region 6 aged ≥ 18 years old. Of the 506 survey participants, 80.3% were female, and 65.0% were 25–59 years old. The survey revealed that 52.2% of participants were classified as having more accurate knowledge, 58.9% were classified as having more positive attitudes, and 80.8% were classified as having more frequent practices regarding “new normal” guidelines, and 54.7% had high QOL. Of the participants, 93.7% agreed that “people who have been fully vaccinated should wear a mask while outside,” and 95.5% wore a face mask outdoors in crowded places. However, 60.9% of participants misunderstood some details regarding online applications for contact tracing and vaccination services, 44.2% felt that these applications were difficult to use, and 33.4% rarely or never downloaded or used these applications. In logistic regression analyses, accurate knowledge of COVID-19 was associated with higher education, being a government employee, monthly family income > 30,000 Thai Baht, and regular use of social media. More positive attitudes regarding “new normal” guidelines and high QOL were associated with positive practices. High QOL was associated with older age, and higher education. Enhancement of attitudes and QOL is also important for improving practices in the general population during the COVID-19 pandemic. Significant factors identified in KAP will be crucial for developing effective prevention and control programs to mitigate the spread of COVID-19. To implement mobile health applications effectively, more work is required to improve the ease of use and promotion strategies.
Longevity-Promoting Pathways and Transcription Factors Respond to and Control Extracellular Matrix Dynamics During Aging and Disease
Authors: Vidović Tinka , Ewald Collin Y.
Published: July 2022

Aging is one of the largest risk factors for cancer, type 2 diabetes, osteoarthritis, cardiovascular diseases, and other age-related pathologies. Here, we give a detailed description of the interplay of chronic age-related pathologies with the remodeling of the extracellular matrix during disease development and progression. Longevity-promoting signaling pathways slow or prevent age-related diseases. In particular, we focus on the mTOR signaling pathway, sirtuins, and canonical longevity-promoting transcription factors, such as FOXO, NF-κB, and Nrf2. We extend our analysis using chromatin immunoprecipitation (ChIP) sequencing and transcriptomic data and report that many established and emerging longevity-promoting transcription factors, such as CREB1, FOXO1,3, GATA1,2,3,4, HIF1A, JUN, KLF4, MYC, NFE2L2/Nrf2, RELA/NF-κB, REST, STAT3,5A, and TP53/p53, directly regulate many extracellular matrix genes and remodelers. We propose that modulation of these pathways increases lifespan and protects from age-related diseases in part due to their effects on extracellular matrix remodeling. Therefore, to successfully treat age-related diseases, it is necessary to better understand the connection between extracellular matrix components and longevity pathways.
Bio-Inspired Vision and Gesture-Based Robot-Robot Interaction for Human-Cooperative Package Delivery
Authors: Joshi Kaustubh , Roy Chowdhury Abhra
Published: July 2022

This research presents a novel bio-inspired framework for two robots interacting together for a cooperative package delivery task with a human-in the-loop. It contributes to eliminating the need for network-based robot-robot interaction in constrained environments. An individual robot is instructed to move in specific shapes with a particular orientation at a certain speed for the other robot to infer using object detection (custom YOLOv4) and depth perception. The shape is identified by calculating the area occupied by the detected polygonal route. A metric for the area’s extent is calculated and empirically used to assign regions for specific shapes and gives an overall accuracy of 93.3% in simulations and 90% in a physical setup. Additionally, gestures are analyzed for their accuracy of intended direction, distance, and the target coordinates in the map. The system gives an average positional RMSE of 0.349 in simulation and 0.461 in a physical experiment. A video demonstration of the problem statement along with the simulations and experiments for real world applications has been given here and in Supplementary Material.
Long-Term Cognitive Outcomes and Associated Quality of Life of Young Adults Who Experienced Liver Transplantation in Early Childhood
Authors: Beath Sue V. , Taylor Zoe , Wray Jo , Passingham Charlotte , Lloyd Carla , Kelly Deirdre A.
Published: July 2022

We evaluated long term outcomes in infants born between 1992 and 2002 with cholestatic liver disease (CLD) who underwent successful liver transplantation (LT). A total of 160 children with CLD were identified: 68 had developmental assessments before and after LT of whom 32 were excluded because they were followed up elsewhere; 16/36 consented to complete measures of IQ, anxiety, depression, health related quality of life (HRQoL), and a habits/employment survey. Illness severity and developmental attainment prior to LT were comparable with the 32 excluded and 20 patients who declined to take part. The IQ of young adults after LT (mean score = 91.13, range 75–108, SD 10.4) was not significantly improved compared to pre-LT scores (mean score = 85.7 range 50–111, SD 17), but was inversely correlated with stunting of growth and duration of disease before LT, highlighting the need for timely LT in CLD. HRQoL scores ranged from 22 to 99 (mean 64.5 SD 20.7), comparable to scores in other LT recipients. Five (31%) had mild-moderate depression; 5 (31%) had moderate-severe anxiety associated with reduced HRQoL (P = 0.01 and P = 0.06, respectively); and nine had problematic fatigue which correlated with reduced HRQoL (r2 = 0.4 P = 0.007). Reduced medication adherence was associated with fatigue (Spearman correlation r2 = 0.267; P = 0.09) and anxiety (Spearman correlation r2 = 0.597; P = 0.02). Raised body mass index was also associated with reduced and health-related quality of life scores PeLTQL© (r2 = 0.379 P = 0.011). Fifteen (94%) were undergoing education or were employed. The long-term neuro-cognitive and psychosocial outcomes of young adults transplanted as babies is encouraging, although anxiety/depression was more common than in the healthy population. Psychosocial questionnaires help identify those young adult LT recipients who may benefit from support.
Imposing Compulsory Rugby Union on Schoolchildren: An Analysis of English State-Funded Secondary Schools
Authors: White Adam John , Batten John , Howarth Nathan E. , Magrath Rory , Piggin Joe , Millward Pete , Parry Keith D. , Lang Melanie , Bullingham Rachael , Pearce Alan J. , Morales Luis , Turner Gary , Humphries Connor Tyler , Hardwicke Jack , Anderson Eric , Kirkwood Graham , Pollock Allyson
Published: July 2022

Objective

To establish the extent to which Rugby Union was a compulsory physical education activity in state-funded secondary schools in England and to understand the views of Subject Leaders for Physical Education with respect to injury risk.

Method

A cross-sectional research study using data obtained under the Freedom of Information Act (2000) from 288 state-funded secondary schools.

Results

Rugby Union was delivered in 81% (n = 234 of 288) of state-funded secondary school physical education curricula, including 83% (n = 229 of 275) of state-funded secondary school boys' and 54% (n = 151 of 282) of girls' physical education curricular. Rugby Union was compulsory in 91% (n = 208 of 229) of state-funded secondary schools that delivered it as part of the boys' physical education curriculum and 54% (n = 82 of 151) of state-funded secondary schools that delivered contact Rugby Union as part of the girls' physical education curriculum. Subject Leaders for Physical Education also perceived Rugby Union to have the highest risk of harm of the activities they delivered in their school physical education curriculum.

Conclusion

Notwithstanding discussions of appropriate measures (i.e., mandatory concussion training, Rugby Union specific qualifications and CPD) to reduce injury risk, it is recommended that Rugby Union should not be a compulsory activity given that it has a perceived high risk of injury and is an unnecessary risk for children in physical education.
Optimization Based Modeling for the Food Supply Chain's Resilience to Outbreaks
Authors: Moynihan Emma , Avraam Charalampos , Siddiqui Sauleh , Neff Roni
Published: July 2022

Scant research focuses on the resiliency of food supply chain networks to outbreaks, despite the estimated 600 million global foodborne illnesses annually. Outbreaks that cross country, state and provincial lines are virulent due to the number of people they can affect and difficulty controlling them. Research is needed on food supply chain networks, which are not well-characterized in relation to foodborne illnesses or generally. This paper introduces the United States Food, Energy, and State Transportation (US-FEAST) model and demonstrates its applicability via analysis of a hypothetical demand shock resulting from multistate food contamination. US-FEAST is an optimization-based model across all fifty states with yearly timesteps to 2030. It is a framework integrating food system data from multiple individual data sources. To calibrate, we develop a bilevel optimization routine to generate synthetic, state-level data and provide estimates of otherwise unavailable data at the intersections of the food and transportation systems. The results of US-FEAST elucidate potential heterogenous state-level variations in response, regional changes in food flows, vulnerabilities in the supply chain, and implications for food system resilience. While the generated data and scenarios are not empirical evidence, they provide insights to aid in planning by projecting outcomes and intervention effects. Our results estimate a 23% beef production decrease and 4% price decrease provide a road map toward data needs for quantifying food system resilience to foodborne illness. US-FEAST and its framework may have global utility for studying food safety in national and international food supply chain networks.
Probiotics and Synbiotics Addition to Bama Mini-Pigs' Diet Improve Carcass Traits and Meat Quality by Altering Plasma Metabolites and Related Gene Expression of Offspring
Authors: Zhu Qian , Song Mingtong , Azad Md. Abul Kalam , Ma Cui , Yin Yulong , Kong Xiangfeng
Published: July 2022

This study evaluated the effects of maternal probiotics and synbiotics addition on several traits and parameters in offspring. A total of 64 Bama mini pigs were randomly allocated into the control (basal diet), antibiotic (50 g/t virginiamycin), probiotics (200 mL/day probiotics), or synbiotics (500 g/t xylo-oligosaccharides and 200 mL/day probiotics) group and fed with experimental diets during pregnancy and lactation. After weaning, two piglets per litter and eight piglets per group were selected and fed with a basal diet. Eight pigs per group were selected for analysis at 65, 95, and 125 days of age. The results showed that the addition of probiotics increased the average daily feed intake of the pigs during the 66- to 95-day-old periods and backfat thickness at 65 and 125 days of age, and that the addition of synbiotics increased backfat thickness and decreased muscle percentage and loin-eye area at 125 days of age. The addition of maternal probiotics increased the cooking yield and pH45min value at 65 and 95 days of age, respectively, the addition of synbiotics increased the meat color at 95 days of age, and the addition of probiotics and synbiotics decreased drip loss and shear force in 65- and 125-day-old pigs, respectively. However, maternal antibiotic addition increased shear force in 125-day-old pigs. Dietary probiotics and synbiotics addition in sows' diets increased several amino acids (AAs), including total AAs, histidine, methionine, asparagine, arginine, and leucine, and decreased glycine, proline, isoleucine, α-aminoadipic acid, α-amino-n-butyric acid, β-alanine, and γ-amino-n-butyric acid in the plasma and longissimus thoracis (LT) muscle of offspring at different stages. In the LT muscle fatty acid (FA) analysis, saturated FA (including C16:0, C17:0, and C20:0) and C18:1n9t contents were lower, and C18:2n6c, C16:1, C20:1, and unsaturated FA contents were higher in the probiotics group. C10:0, C12:0, and C14:0 contents were higher in 65-day-old pigs, and C20:1 and C18:1n9t contents were lower in the synbiotics group in 95- and 125-day-old pigs, respectively. The plasma biochemical analysis revealed that the addition of maternal probiotics and synbiotics decreased plasma cholinesterase, urea nitrogen, and glucose levels in 95-day-old pigs, and that the addition of synbiotics increased plasma high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and total cholesterol concentrations in 65-day-old pigs and triglyceride concentration in 125-day-old pigs. The addition of maternal probiotics and synbiotics regulated muscle fiber type, myogenic regulation, and lipid metabolism-related gene expression of LT muscle in offspring. In conclusion, the addition of maternal probiotics and synbiotics improved the piglet feed intake and altered the meat quality parameters, plasma metabolites, and gene expression related to meat quality.
Single-Voxel Proton Magnetic Resonance Spectroscopy of the Thalamus in Idiopathic Epileptic Dogs and in Healthy Control Dogs
Authors: Mauri Nico , Richter Henning , Steffen Frank , Zölch Niklaus , Beckmann Katrin M.
Published: July 2022

The role of magnetic resonance spectroscopy (MRS) in the investigation of brain metabolites in epileptic syndromes in dogs has not been explored systematically to date. The aim of this study was to investigate metabolites in the thalamus in dogs affected by idiopathic epilepsy (IE) with and without antiepileptic drug treatment (AEDT) and to compare them to unaffected controls. Our hypothesis is that similar to humans with generalized epilepsy and loss of consciousness, N-acetyl aspartate (NAA) would be reduced, and glutamate–glutamine (Glx) would be increased in treated and untreated IE in comparison with the control group. In this prospective case–control study, Border Collie (BC) and Greater Swiss Mountain dog (GSMD) were divided into three groups: (1) healthy controls, IE with generalized tonic–clonic seizures with (2) and without (3) AEDT. A total of 41 BC and GSMD were included using 3 Tesla single-voxel proton MRS of the thalamus (PRESS localization, shortest TE, TR = 2000 ms, NSA = 240). After exclusion of 11 dogs, 30 dogs (18 IE and 12 healthy controls) remained available for analysis. Metabolite concentrations were estimated with LCModel using creatine as reference and compared using Kruskal–Wallis and Wilcoxon rank-sum tests. The Kruskal–Wallis test revealed significant differences in the NAA-to-creatine (p = 0.04) and Glx-to-creatine (p = 0.03) ratios between the three groups. The Wilcoxon rank-sum test further showed significant reduction in the NAA/creatine ratio in idiopathic epileptic dogs under AEDT compared to epileptic dogs without AEDT (p = 0.03) and compared to healthy controls (p = 0.03). In opposite to humans, Glx/creatine ratio was significantly reduced in dogs with IE under AEDT compared to epileptic dogs without AEDT (p = 0.03) and controls (p = 0.02). IE without AEDT and healthy controls did not show significant difference, neither in NAA/creatine (p = 0.60), nor in Glx-to-creatine (p = 0.55) ratio. In conclusion, MRS showed changes in dogs with IE and generalized seizures under AEDT, but not in those without AEDT. Based upon these results, MRS can be considered a useful advanced imaging technique for the evaluation of dogs with IE in the clinical and research settings.
Estimating the Effect of a Bovine Viral Diarrhea Virus Control Program: An Empirical Study on the Performance of Dutch Dairy Herds
Authors: Yue Xiaomei , Wu Jingyi , van der Voort Mariska , Steeneveld Wilma , Hogeveen Henk
Published: July 2022

More and more European countries have implemented a bovine viral diarrhea virus (BVDV) control program. The economic effects of such programs have been evaluated in simulations, but empirical studies are lacking, especially in the final stage of the program. We investigated the economic (gross margin) and production effects (milk yield, somatic cell count, and calving interval) of the herds obtaining BVDV-free certification based on longitudinal annual accounting and herd performance data from Dutch dairy herds between 2014 and 2019, the final stages of the Dutch national BVDV-free program. This study was designed as a case-control study: two types of case herds were defined for two analyses. The case herds in the first analysis are herds where the BVDV status changed from “BVDV not free” to “BVDV free” during the study period. The not-free status refers to a herd that participated in the BVDV-free program but had not yet obtained the BVDV-free certification. In the second analysis, the case herds started participating in the Dutch BVDV-free program during the study period and obtained the BVDV-free certification. Control herds in both analyses were BVDV-free during the entire study period. Potential bias between the covariates of the two herd groups was reduced by matching case and control herds using the propensity score matching method. To compare the differences between case and control herds before and after BVDV-free certification, we used the time-varying Difference-in-Differences estimation (DID) methodology. The results indicate that there was no significant change in milk yield, somatic cell count, calving interval, and gross margin upon BVDV-free certification. There are several possible explanations for the non-significant effects observed in our study, such as the final stage of the BVDV control program, not knowing the true BVDV infection situation in case herds and not knowing if control measures were implemented in case herds prior to participating in the BVDV-free program. In our study, the effects of BVDV-free certification might have been underestimated, given that the Dutch BVDV control program became mandatory during the study period, and some of the case herds might have never experienced any BVDV infection. The results of this study suggest that in the final stage of the BVDV control program, the program may no longer have a clear benefit to the herd performance of participating dairy herds. When designing national programs to eradicate BVDV, it is therefore important to include incentives for such farms to motivate them to join the program.
Weighted Gene Co-expression Network Analysis Revealed That CircMARK3 Is a Potential CircRNA Affects Fat Deposition in Buffalo
Authors: Feng Xue , Zhao Jinhui , Li Fen , Aloufi Bandar Hamad , Alshammari Ahmed Mohajja , Ma Yun
Published: July 2022

Background

Buffalo meat is increasingly widely accepted for consumption as it shares several quality attributes with cattle meat (beef). Hence, there is a huge opportunity for growth in the buffalo meat industry. However, buffalo meat has relatively low intramuscular fat (IMF) content, affecting its flavor, tenderness and juiciness. As there is a dearth of information on factors that control fat deposition, this study was undertaken to provide new candidate factor associated with buffalo fat deposition. Circular RNA (circRNA) is a novel class of non-coding RNA with a closed-loop structure, and play an important role in fat deposition.

Methods

In this study, weighted gene co-expression network analysis (WGCNA) was used to construct a circRNA co-expression network and revealed a candidate circRNA that may affect the IMF deposition of buffalo as determined by RT-qPCR, semiquantitative PCR and gain-of-function experiments.

Results

Herein, WGCNA determined that one module (turquoise module) is significantly associated with the growth and development stages of buffalo. Further analysis revealed a total of 191 overlapping circRNAs among differentially expressed (DE) circRNAs and the co-expression module. A candidate circRNA was found, 21:6969877|69753491 (circRNA_ID), with a reported involvement in lipid metabolism. This circRNA is stably expressed and originates from the MARK3 gene, hence the name circMARK3. circMARK3 is highly expressed in adipose tissue and mature adipocytes and is located in the cytoplasm. Gain-of-function experiments demonstrated that circMARK3 promoted adipogenic differentiation of buffalo adipocytes and 3T3-L1 cells by up-regulating the expression levels of adipogenic marker genes PPARG, C/EBPα and FABP4.

Conclusion

These results indicate that circMARK3 is a potential factor that promotes fat deposition by regulating adipocyte differentiation and adipogenesis in buffalo.
Design and Analysis of a Novel Floating Docking Mechanism for On-Orbit Refueling
Authors: Sun Zhicheng , Li Shipeng , Zhang Huan , Lei Haiming , Song Xiaodong
Published: July 2022

The docking mechanism is a key component for on-orbit refueling technology. In this paper, the design and analysis of a novel floating docking mechanism for on-orbit berthing-based refueling is presented. Compared with traditional berthing and docking, the berthing here is high in success rate and low in impact, which is accomplished by stretching out a docking subassembly instead of pulling back the client spacecraft. However, the berthing also has two problems: initial deviations between two spacecraft and an additional force generated by a hard alloy refueling pipe, which both seriously affect the docking operation. Thus, the docking mechanism is designed to have alignment abilities and decrease the additional force as much as possible. Based on the principles above, we introduced spring pins and a helical refueling pipe to design a light, compact, and simple docking mechanism. To further reduce the additional force, we proposed an elliptical-helical pipe and analyzed its mechanical properties. Finally, simulations and experiments were conducted to validate the proposed mechanism. The results show that the proposed mechanism with an elliptical-helical pipe has a high tolerance for linear and angular misalignment and superior dynamic performance during docking.