bluuebunny/crossref_metadata_2025 huggingface dataset:
Prevalence of Headache Due to the Use of Methylphenidate: A Systematic Review
Authors: Santana Luís Eduardo Teixeira Santos , Ferracioli Patricia Ramos Borges , Borges Wagner Ramos
Published: November 2023

Introduction: Attention Deficit Hyperactivity Disorder (ADHD) is a disease that affects the functional and neurological development of individuals and is characterized by hyperactivity and impulsion, it is present in 5% of children and 2.5% of adults across the globe. Its treatment is carried out with methylphenidate which improves the clinical condition of individuals, but this medication also has adverse effects, and in this study we evaluated the headache associated with this medication. Objective: The aim of this study is to define, through an analysis of the literature, the prevalence of headache in methylphenidate users. Methods: A systematic review was conducted with searches on PUBMED and SCIELO. The terms were adapted according to the research platform used, whose combinations involved the following descriptors: ´´attention deficit disorder with hyperactivity``; ´´methylphenidate`` and ´´headache``. The study included randomized clinical trials; studies conducted in humans; studies that analyze headache as a side effect of using methylphenidate; studies carried out in the last 10 years. Results: Of the 44 articles identified, five were included for analysis, totaling 593 participants, with a male predominance. The prevalence of headache ranged from 4.3% to 19.5%, higher than the population that does not use methylphenidate, which reinforces the need to monitor, diagnose and intervene on possible negative impacts of headache caused by methylphenidate. Conclusion: The prevalence of headache resulting from the use of methylphenidate ranged from 4.3% to 19.5%. It is also said that there are few studies that associate headache and methylphenidate. The proportion in which the headache appears in patients using methylphenidate, varies according to the presentation of the drug.
Knowledge and Attitudes Towards Classroom Active Breaks Among Brazzaville’s Middle-Schoolers and Teachers of the Antonio Agostinho NETO General Education College
Authors: Mabounda Kounga Paul Roger , Nsompi Florent , Bouhika Eddie Janvier , Boussana Alain Marc
Published: November 2023

Background: Although classroom activity breaks (CAB) are essential for improving the learner's level of moderate to vigorous physical activity, they are not implemented and the impact of their effects is very poorly understood. Purpose: To determine students and teachers' knowledge on CAB and analyze the factors related to AA Neto middle school teachers' CAB knowledge. Method: A total of 90 students and 52 teachers Participated in this study. Student’s knowledge on CPAB and teacher’s knowledge and attitude on CAB and factors related to teacher’s knowledge on CAB were recorded with a questionnaire for about 20 minutes respectively. Results: The prevalence of student’s unawareness of CAB was high (87.8%) with a predominance of girls (92%). The prevalence of teacher’s unawareness of CAB was also high (78.8%) with a predominance of men (9 out of 2). Teachers had an unfavorable attitude towards the introduction of CAB. Lack of awareness of CAB was found to be significantly associated with age (OR = 0.95, CI = 0.92–0.99) and middle school diplomas (OR = 2.24, CI = 1, 03–4.84) and high school diploma (OR = 5.06, IC = 1.72–14.86). Conclusion: Overall, these results demonstrate a significant lack of CAB knowledge among students and teachers at AA Neto middle school. Similarly, teachers have a negative attitude towards CAB. Finally, the age, the diploma and the behavior change at the individual level were predictors of teachers' unawareness.
Autism: New Conceptual Propositional Hypothesis
Authors: Ojea Rúa Manuel
Published: November 2023

The initial sensory- attention perceptual processing in people with autism spectrum disorder forms a global analysis, but semantic content is limited, therefore, they need to complete their semantic understanding, through second analysis with purpose to encode a greater number of local details, units and/ or conceptual categories. This cognitive action developed through relational connections with concepts previously stored in permanent memory (semantic memory). Study has been designed a qualitative- quantitative triangulated way. The qualitative analysis is based on a textual- conceptual perceptual and visual-perceptual study, while the quantitative analysis has been achieved through non- parametric statistical comparative tests regarding to the grouped variable: “participants”. A total of 10 participants have collaborated in this study, 5 neurotypical participants and 5 participants with autism spectrum disorder, aged between 16-17 years old. The comparative analysis allows delimit partial differential aspects throughout study variables, according to participants´ group variable and, hence, the development of a new cognitive- perceptive theory of specific propositional processing to people with autism: Global Cyclic Theory has been concluded.
Interaction Between Economic Growth and Oil Products Importation in Nigeria Using Autoregressive Lagged Ordered Model (ARLOM)
Authors: Amaefula Chibuzo G. , Akuebionwu Richardson A.
Published: November 2023

The paper investigates the interaction between economic growth and oil products importation in Nigeria both in the long-run and short-run adopting autoregressive lagged ordered model (ARLOM). The data on the two variables span from 1983 to 2021. The pre-test analysis shows that both variables have the same order of integration, co-integrated in their normal levels and stationary at first difference. Estimation based on the least square method, shows that importation of oil products interacts significantly with economic growth at the long-run at 5% level. Moreover, there is no evidence of relationship in the short-run. Therefore, we recommend that if resources are well managed and oil importation dealings are very transparent, then Nigeria economy can grow better.
Marketing Strategy of OPPO Mobile Phone in Pakistan
Authors: Ahmed Shahzad , Yongyuan Cheng , Bashir Muhammad Tariq , Jamee Bilal , Atta Shahid Hussain , Shah Syed Haseeb Haider , Kalsoom Habiba , Younas Muhammad Waqas
Published: November 2023

As an emerging smart phone consumer market in recent years, Pakistan has a low domestic smart phone penetration rate and a huge number of potential smart phone users. This study takes the marketing of OPPO mobile phone in Pakistan as the research object, uses 7P theory to analyze the marketing case of OPPO mobile phone in Pakistan, and puts forward some optimization suggestions in terms of product, price, channel, promotion, personnel, tangible display and process. The research methodology employed in this study is centered around the administration of a questionnaire survey, which aims to provide a comprehensive analysis of the research conducted on onions. Through the optimization of OPPO mobile phone strategy in Pakistan, this study hopes to actively explore the international market and optimize the localization strategy for Chinese mobile phone brands represented by OPPO mobile phone.
Wochenrückblick: Abmahndeckelung, Meinungsfreiheit, Lobbyplag
Authors:   telemedicus.info
Published: November 2023

Trotz Streitigkeiten soll das Abmahngesetz nach Koalitionsaussagen noch kommen. Außerdem im Wochenrückblick: Europäischer Menschenrechtsgerichtshof zu Urheberrecht und Meinungsfreiheit, Lobbyplag startet, Klarnamenpflicht bei Facebook und Arbeitsbedingungen bei Amazon.
Webschau
Authors: Seebörger Immo
Published: November 2023

hallo The post Webschau appeared first on iRights.info.
Verwaiste Werke: Die Regelung kommt, die Probleme bleiben
Authors: Klimpel Paul
Published: November 2023

Die Umsetzung der EU-Richtlinie zu verwaisten Werken wird an den Problemen von Archiven, Museen und Bibliotheken nicht viel ändern: Die Rechtesituation bei älteren Werken bleibt weiterhin unklar. Doch vor allem wird sie das Problem angemaßter Rechte nicht lösen.
Bundestag will Softwarepatente begrenzen
Authors: Pachali David
Published: November 2023

Seltene Einigkeit: Der Bundestag will heute Abend einen interfraktionellen Antrag beschließen, der Patente im Softwarebereich begrenzen will. Der Antrag von CDU/CSU, SPD, FDP und Grünen (PDF) fordert im Kern, Software weiterhin übers Urheberrecht zu schützen (proprietär oder frei), statt einen weiteren, parallelen Schutz über Patente entstehen zu lassen.
Welches Problem soll die Kulturflatrate lösen?
Authors: Braun Ilja
Published: November 2023

Der Urheberrechtler Gerald Spindler hat im Auftrag der Grünen Modelle für eine Kulturflatrate durchgerechnet. Die mögliche Höhe einer solchen Abgabe schreckt jetzt allerdings auch Befürworter ab. Doch wer nun allein auf Marktlösungen setzt, gibt den politischen Gestaltungs­willen auf. Dass der Kampf gegen die Piraterie erhebliche Kollateralschäden mit sich bringt, wird heute von niemandem mehr ernsthaft bestritten.
Öffentlich-rechtliche Archive: Reader „Digital Public Spaces” erschienen
Authors: Pachali David
Published: November 2023

Während in Deutschland über Haushaltsabgabe, Depublikation und Verweildauerkonzepte diskutiert wird, arbeitet die BBC unter dem Titel „Digital Public Space” zusammen mit weiteren öffentlichen Einrichtungen wie Museen nicht nur an einem digitalen Archiv, sondern nebenbei auch an ihrer Neuerfindung im Netz.
Veranstaltungshinweise Dezember 2023
Authors: Fischer Georg
Published: November 2023

+++ Workshop Urheberrecht +++ Datenschutz und Künstliche Intelligenz +++ Creative Commons +++ Konferenz: Wissenschaftliche Publikationskulturen +++ Ausgewählte Veranstaltungen im Berliner Raum und online zu Open Research in Wissenschaft und Kulturerbeeinrichtungen
Wochenrückblick: Videospiele und Kopierschutz, BGH zu Rapidshare, Facebook-Abmahnungen
Authors:   telemedicus.info
Published: November 2023

Der Europäische Gerichtshof muss sich mit Nintendo-Adapterkarten befassen, der Bundesgerichtshof veröffentlicht seine Entscheidung im Fall Rapidshare, ein Gericht erklärt automatisierte Facebook-Abmahnungen zur Impressumspflicht für zulässig. Außerdem im Wochenrückblick: Facebook-Gesichtserkennung, Kommissions-Plan zur „Cybersicherheit”.
Verpatzter „Sim City”-Start: Worst Case des Cloud-Gamings
Authors: Wragge Alexander
Published: November 2023

Wenn ein Online-Spiel offline geht: Der Fall „Sim City“ zeigt, was beim Cloud-Computing schiefgehen kann. Unfreiwillig hat die Spielefirma Electronic Arts die große Schwäche des Cloud-Gamings offenbart: die Server des Anbieters müssen permanent online erreichbar sein. Genau das misslang nach dem Verkaufsstart von „Sim City 5” am vergangenen Donnerstag.
Elektrischer Reporter über GEMA und die C3S
Authors: Pachali David
Published: November 2023

Alle schimpfen auf die GEMA, manche versuchen es mit einem neuen Modell. Der Elektrische Reporter beim ZDF hat in der letzten Folge über die Kritik von Künstlern an der GEMA und die sich neu formierende Verwertungsgesellschaft C3S berichtet. Zu Wort kommen Musikerin Zoe Leela, GEMA-Syndikus Alexander Wolf und iRights.info-Kollege John Weitzmann. Hier das Video:
Was Rot-Grün in Niedersachsen beim Urheberrecht verspricht
Authors: Pachali David
Published: November 2023

Eine Open-Data-Strategie, freie Software in Schulen und Behörden, Unterstützung für eine entschärfte Störerhaftung, Ablehnung des Leistungsschutzrechts – welche Absichten der Koalitionsvertrag der neuen rot-grünen Regierung in Niedersachsen beim Urheberrecht festhält, gibt es zusammengefasst bei Wikimedia und Netzpolitik.org. The post Was Rot-Grün in Niedersachsen beim Urheberrecht verspricht appeared first on iRights.info.
Bundestag beschließt längere Schutzfristen, Grundstückseigentümer, Facebook-Klarnamen
Authors:   telemedicus.info
Published: November 2023

Der Bundestag hat längere Schutzfristen für Tonaufnahmen beschlossen, der Bundesgerichtshof bestätigt seine Fotografie-Rechtsprechung, Facebooks Klarnamenpflicht bleibt erlaubt. Außerdem im Wochenrückblick: Telekom und Netzneutralität, Verfassungsgericht zur Antiterrordatei, Grünbuch zur Medienkonvergenz, Werbeverbot und Rundfunkbeitrag.
Musikwirtschaft: Vom Besitz zum Zugang – oder nicht?
Authors: Pachali David
Published: November 2023

Streaming-Dienste sorgen für Optimismus in der Musikindustrie. Zu Recht? Der Kulturwirtschaftsforscher Peter Tschmuck hat den ersten Teil einer Artikelreihe zum Thema veröffentlicht, in der er den Wandel der Geschäftsmodelle, Nutzungsgewohnheiten und die Frage, was Streaming-Modelle für Labels, Verlage und Musiker bringen, untersucht.
FAIR Data Digest #22
Authors: Lieber Sven
Published: November 2023

How I solved data integration performance problems by rewriting SPARQL queries or changing the approach. Food for thought that might help you too!
ULD: „Ein gewisses Misstrauen ist berechtigt”
Authors: Wragge Alexander
Published: November 2023

Wie informiert wagen Nutzer, Unternehmen und Institutionen den Schritt in die Cloud? Die Datenschutzexperten Marit Hansen und Ninja Marnau vom Unabhängigen Landeszentrum für Datenschutz Schleswig-Holstein (ULD) erläutern im Interview technische und rechtliche Fragen. Vom “Mitlese-System” bei Facebook über die Datenverschlüsselung bis zur Profilbildung.
Zugang zu amtlichen Werken: „Ein rechtsstaatliches Armutszeugnis”
Authors: Pachali David
Published: November 2023

Gesetzestexte, Gerichtsentscheidungen und andere amtliche Werke sind frei von Urheberrechten – eigentlich. Offen zugänglich sind sie deshalb noch nicht, etwa aufgrund von Verträgen mit privaten Anbietern. Der Anwalt Thomas Fuchs im Interview.  Zur Person:  Thomas Fuchs ist Anwalt und Gründer der Rechtsdatenbank lexetius.com. Für den Anbieter Lexxpress verfasste er ein Gutachten über die Rechtsdatenbank Juris (PDF).
Honorare: Übersetzer veröffentlichen offenen Brief an Random House
Authors: Pachali David
Published: November 2023

Deutschsprachige Übersetzerverbände haben heute einen offenen Brief an die Verlagsgruppe Random House (PDF) veröffentlicht und fordern eine angemessene Vergütung bei Kinder- und Jugendbüchern, die die entsprechenden Verlage bislang schuldig blieben. Sie verweigerten höhere Honorare und versuchten sie im Einzelfall noch zu senken.
Europäischer Gerichtshof: Fernsehsender können Streaming untersagen
Authors: Pachali David
Published: November 2023

Fernsehen ohne Fernsehgerät: Das britische Unternehmen TV Catchup machte es möglich und streamte frei empfangbare Fernsehsender ins Internet, jedenfalls für englische Nutzer und Gebührenzahler. Einige Fernsehsender, darunter die des dortigen ITV-Netzwerks, klagten dagegen. Der Europäische Gerichtshof entschied am Donnerstag, dass diese das Weiterleiten des Signals ins Internet per Stream verbieten können.
Wie funktioniert Strafverfolgung in der Cloud?
Authors: Pachali David
Published: November 2023

Ob persönliche Dokumente im Webspeicher oder Telefonieren über das Internet: „Die Cloud” lockt Strafverfolgungs- und Sicherheitsbehörden mit umfangreichen Daten und stellt sie zugleich vor neue Herausforderungen. Wer kann was einsehen, welche Regeln gelten hierfür? Früher war es für Ermittler einfach: Dokumente wurden in Aktenordnern gespeichert, Gespräche über das gute alte Telefonnetz geführt.
Schwarz-Gelb: Gesetz gegen Massenabmahnungen kommt noch
Authors: Wragge Alexander
Published: November 2023

Die Zeit wird knapp. Noch vor den Wahlen will die Bundesregierung Abmahnkosten wegen Urheberrechtsverstößen im Internet deckeln. Von einem Scheitern will man in der Koalition nichts wissen. „Der Gesetzentwurf wird in einer der nächsten Kabinettsitzungen beschlossen werden“, teilte das Pressereferat des Kulturstaatsministers Bernd Neumann (CDU) am Mittwoch gegenüber iRights.info mit.
Kualitas Pendidikan di Daerah Pedesaan, Studi Kasus Desa Rowotamtu dan Tisnogambar
Authors: Ivana Grace Sofia Radja  , Leo Riski Sunjaya  , Yohan Eka Wahyunda Febriansyah
Published: November 2023

Education is a process needed to obtain balance and perfection in the development of individuals and society. Education itself is faced with various problems that become obstacles to the quality of education itself. This can be seen in various aspects, some of which include the lack of adequate physical facilities such as the feasibility of buildings used in the learning process. These problems can hinder the development of students to reach their best potential and cause inequality in terms of access to quality education. There are differences in the quality of education in rural and urban areas, where rural areas have more specific challenges such as lack of school facilities, difficulty of access, and technological and social changes. In the context of education, technology has changed the way we learn, access information and communicate. Social changes, such as changing demographics, can also affect the way we design education systems. These factors create pressures on education that require creative thinking and innovative solutions. This research uses qualitative research methods through a phenomenological approach. The theoretical foundation used in this research is the functional structural theory proposed by Talcott Parson. Data collection in this study used interviews, observation, and documentation.
The enigmatic spherical-horned Tsaidamotherium reveals an unsuccessful grazing adaptation of early giraffoids
Authors: Wang Shiqi , Ye Jie
Published: November 2023

Tsaidamotherium was previously believed to be an “Ovibos-like” bovid because of its specialized basicranial morphology, which closely parallels that of living Ovibos. However, the plate-like headgear of Tsaidamotherium is so strange that confidently categorizing it as bovid horncores is challenging. In this paper, we conducted a comparative development study on the morphology of Tsaidamotherium. The headgear of a juvenile Tsaidamotherium exhibits a stepwise fusion state, with a distinct seam between the headgear and the calvaria. This morphology contradicts the typical development of bovid horncore anlagen, where fusion occurs in the early stages and is limited to a small area, making the fusion seam unobservable. Developmental conservatism dictates that primary bovid horncores form in pairs and strictly develop on the frontals. However, Tsaidamotherium possesses only one headgear primarily supported by the parietal. Therefore, the Tsaidamotherium headgear cannot be classified as bovid horncores but aligns better with giraffoid ossicones in terms of both development and morphology. Tsaidamotherium, as a miniaturized grazing giraffoid, likely represents a giraffoid lineage that adapted to open-land grazing, competing with various bovids but ultimately facing defeat. This may serve as another example to understand the early evolution and radiation of giraffoids: basal giraffoids exhibited diversity and expanded into open ecosystems. While most failed as small grazers, some survived as high-level browsers, eventually giving rise to Giraffa, which succeeded with an extremely long neck among giraffoids.
A comparative study on paper recycling wastewater treatment using microwave irradiation and centrifuge technology
Authors: Özkan Uğur , Şahin Halil Turgut
Published: November 2023

In this study, the effect of MW irradiation on wastewater obtained from recycling office papers was evaluated. Wastewater samples were centrifuged in the MW oven for periods between 1.0 minutes and 15.0 minutes after MW irradiation. The effect of a centrifuge on the general appearance of wastewater samples was determined. There was no significant pH change depending on treatment conditions. MW irradiation affects electrical conductivity (EC) and Total Dissolved Solids (TDS). It was found to be in the range of 177 ppm for the sample (A1) centrifuged only for 1.0 min and 241 ppm for the MW irradiated and 15.0 min. It is significant to note that all wastewater samples were either centrifuged only (group A) or MW irradiated and then centrifuged (group B) and showed lower ORP values than the control. The highest ORP value of 309 mV was found in the control, but the lowest value of 251 mV was found for the MW irradiated sample (B1) centrifuged for 1.0 minutes. The lowest turbidity values were seen in control and MW irradiated samples with the longest centrifugation (15.0 min). 28 NTU was measured for samples centrifuged only (A15) at 15.0 min conditions and 10 NTU (B15) for MW irradiated and subsequently centrifuged samples. The highest turbidity reduction of 143 NTU was found in a sample under 1.0 min centrifugation. There is a positive relationship between turbidity reduction and centrifuge time, but paper recycling wastewater MW treatments further reduce the effects of turbidity values with less centrifuge time.
Pengaruh Lama Waktu Biofermentasi Chromolaena odorata dengan Sumber Karbon Gula Lontar Cair Terhadap Konsentrasi pH, VFA Total, NH3 dan Produksi Gas Metan Secara in vitro
Authors: Petan Tamara , Oematan Gustaf , Dami Dato Twen O , Lestari Gusti Ayu Y.
Published: November 2023

Tujuan penelitian ini adalah untuk mengetahui pengaruh lama waktu biofermentasi Chromolaena odorata dengan sumber karbon gula lontar cair terhadap konsentrasi pH, VFA total, NH3 dan produksi gas metan secara in vitro. Metode yang digunakan dalam penelitian ini adalah metode percobaan yakni menggunakan Rancangan Acak Lengkap (RAL) dengan 4 perlakuan  dan 4 ulangan. Perlakuan tersebut adalah LB21 : lama biofermentasi 21 hari sebagai kontrol, LB14 : lama biofermentasi 14 hari, LB7 : lama biofermentasi 7 hari, LB0 : lama biofermentasi 0 hari. Variabel yang diamati adalah pH, VFA total, NH3, dan produksi gas metan. Hasil analisis statistik menunjukkan bahwa biofermentasi Chromolaena odorata dengan sumber karbon gula lontar cair berpengaruh nyata (P<0,05) terhadap konsentrasi pH dan NH3 sedangkan, pada VFA total dan produksi gas metan berpengaruh tidak nyata (P>0,05). Disimpulkan bahwa lama waktu biofermentasi mempengaruhi pH dan NH3 sedangkan tidak mempengaruhi VFA total serta produksi gas metan. Lama biofermentasi 14 hari memberikan nilai pH yang terbaik sedangkan pada 7 hari memberikan NH3 yang terbaik.
Residential Time Spent and Homicide during the COVID-19 Pandemic
Authors: Cubukcu Suat , Darcan Emirhan , Aksu Gokhan
Published: November 2023

The United States has witnessed a significant upsurge in homicide rates during the COVID-19 pandemic (NCHS, 2021). While multiple theories attempt to account for this increase, our study examines the impact of changes in human mobility resulting from stay-at-home and social distancing measures on variations in homicide incidents. We conducted a fixed-effects Poisson regression analysis using panel data that encompasses the day of the week and week collected from Chicago between February 2020 and July 2021. Our findings indicate that the increased time spent in residential settings due to stay-at-home orders is not a significant factor in explaining the rise in homicide numbers. Instead, our study suggests that the pandemic as a whole and its influence on individual strains provide a more plausible explanation for the increase in homicide incidence.
Adult Acute Lymphocytic Leukemia: Strategies for Selection of Consolidation Therapy
Authors: Logan Aaron C.
Published: November 2023

The 2 primary treatment options for adult acute lymphoblastic leukemia (ALL) are pediatric-inspired Berlin-Frankfurt-Münster protocols and the hyper-CVAD (cyclophosphamide, vincristine, doxorubicin, and dexamethasone) regimen—these treatment strategies are now being augmented with novel agents. Current strategies also emphasize measurable residual disease (MRD) quantification as a critical tool for determining the treatment course. For patients with MRD-positive ALL, the standard of care has shifted toward blinatumomab, resulting in improved outcomes and survival rates. Another novel agent, inotuzumab ozogamicin, is also being explored for the treatment of earlier stages of disease in patients with ALL. For Philadelphia chromosome (Ph)–negative ALL, the NCCN Guidelines recommend treatment with blinatumomab followed by allogeneic transplants for patients remaining MRD-positive after initial therapy. For patients achieving MRD negativity at the level of 10-4, blinatumomab is now recommended as consolidation, with or without subsequent allotransplant, depending on patient disease risk features. For Ph-positive ALL, the use of tyrosine kinase inhibitors in combination with blinatumomab has demonstrated excellent efficacy, indicating the growing importance of combination targeted therapies to improve outcomes and decrease the toxicity of therapy in adults with ALL.
Management of Newly Diagnosed Multiple Myeloma Based on Risk Stratification
Authors: Callander Natalie S.
Published: November 2023

In the context of newly diagnosed multiple myeloma, recent advances in risk assessment have influenced treatment decisions and paved the way for more individualized approaches. The current NCCN Guidelines for Multiple Myeloma outline the updated staging system, highlight various high-risk features for disease progression/relapse, and provide evidence-based recommendations for myeloma therapy. Although the therapeutic landscape continues to shift toward increased risk adaptability, ongoing efforts should place an emphasis on tackling modifiable risks.
Chronic Myeloid Leukemia/Myelofibrosis: TKI Therapy and Toxicity Management
Authors: Hobbs Gabriela S. , Bell Christopher
Published: November 2023

Recent advances in the understanding of the molecular basis of chronic myeloid leukemia (CML) and myelofibrosis have led to more effective treatment options, with survival now close to that of age-matched controls in CML. The latest updates to the NCCN Guidelines for CML reflect the rapidly evolving treatment landscape, emphasizing the increasing importance of personalized medicine and various targeted therapies. For patients with CML, standard of care involves tyrosine kinase inhibitors such as imatinib, dasatinib, bosutinib, nilotinib, ponatinib, and asciminib, tailored to patient-specific factors and the severity of adverse events. In patients with myelofibrosis, the Janus kinase inhibitors ruxolitinib, pacritinib, and fedratinib have yielded improved outcomes. Critical strategies for managing treatment-related adverse events to optimize the quality of life for patients with these hematologic malignancies were also highlighted.
Various memories of Rumen Maleev - the colleague and friend
Authors: Troyanski Stanimir
Published: November 2023

This is Stanimir Troyanski's personal account of the late Professor Rumen Maleev.The author shares his reminescences about his dear friend and colleague.
Assessment of the Functionality of the Academic Librarians in the Philippines During COVID-19 Pandemic
Authors: Carbonilla Ciara Junette O. , Falculan Ritzel F. , Fiedacan Aloisa Vergyl R. , Morales Jennifer S , Sorquia Rosemarie Gil B. , Carbonilla Michelle O. , Balila Jolly S. , Gasang Ma. Carina L.
Published: November 2023

With the outbreak of COVID-19, the Philippine government declared a lockdown of cross-border supermarkets and educational institutions, affecting library services around the world. Academic libraries struggle to choose the specific services and methods they offer, from minimal dialogue to no user dialogue. This study aims to assess the functionality of academic librarians during COVID-19 pandemic as a basis for enhanced guidelines for academic libraries in the Philippines. Researchers used a qualitative approach, specifically the phenomenological study and interviewed a total of five academic librarians. Participants from the study are from selected Adventist institutions chosen through heterogeneous purposive sampling. Interviews were video recorded, transcribed, and analyzed. Results revealed that COVID-19 pandemic has brought challenges to the libraries such as internet connection issue, budget constraints, usable platforms, and limited online resources, yet they continued their operations and services through via online.  Five out of seven librarians consider the COVID -19 as positive because despite the current situation, they continued receiving support from their administrators that speeded up the digitization for their collection.
Pengaruh Kontrak Konsumen Dan Sarana Prasarana Terhadap Efektivitas Pendapatan PT. PLN (Persero) Area Tanjungkarang
Authors:   STIE Krakatau, Yani David Ahmad , Rachmadi Agung ,   STIE Krakatau
Published: November 2023

Penelitian yang akan dilaksanakan jenis Penelitian Deskriptif. Jenis penelitian ini adalah penelitian yang bermaksud membuat pemaparan secara sistimatis, faktual, dan akurat mengenai fakta-fakta dan sifat-sifat populasi tertentu. Penelitian ini menggunakan 69 responden penelitian. Ada tiga variabel dalam penelitian ini yaitu : 2 (dua) Variabel bebas (X1 dan X2) dan 1 (satu) variabel terikat dimana kontrak konsumen (X1) dan sarana prasarana (X2) sebagai variabel bebas dan efektifitas pendapatan (Y) sebagai variabel terikat. Dari hasil pengolahan data telah berhasil ditemukan jawaban hipotesis yakni sebagai berikut; terdapat pengaruh kontrak konsumen (X1) terhadap efektifitas pendapatan(Y), dengan tingkat pengaruh (R-square) sebesar 38,6% yang berarti kontrak konsumen memberikan pengaruh sebesar 38,6% terhadap efektifitas pendapatan. Terdapat pengaruh antara sarana prasarana (X2) dengan efektifitas pendapatan (Y), dengan tingkat pengaruh sebesar 23,4% yang berarti bahwa sarana prasarana memberikan pengaruh sebesar 23,4% terhadap efektifitas pendapatan. Terdapat pengaruh antara kontrak konsumen (X1), sarana prasarana (X2) dengan efektifitas pendapatan (Y), dengan tingkat pengaruh sebesar 46,1% yang berarti bahwa kontrak konsumen dan sarana prasarana memberikan pengaruh sebesar 46,1% terhadap efektifitas pendapatan.
Pengaruh Aturan Etika Dan Independensi Terhadap Kepuasan Kerja Internal Auditor (Studi pada Auditor Pemerintah di BPKP PerwakilanProvinsi Lampung)
Authors:   STIE Gentiaras, Linda Linda
Published: November 2023

BPKP Perwakilan Provinsi Lampung merupakan salah satu unit kerjadari Badan pengawasan keuangan dan pembangunan yang merupakan lembaga pemerintahan Non Departemen yang berkedudukan dibawah dan bertanggung jawab langsung kepada presiden. Hal yang dibutuhkan dari internal auditor adalah pandangan yang luas serta pemahaman terhadap proses manajerial dan yang berkaitan dengan manusia, yang mendasari fungsi internal auditor. Profesi akuntan tidak terlepas dari etika bisnis yang . Aturan etika adalah kumpulan asas atau nilai moral yang menjadi pegangan bagi seseorang atau suatu kelompok dalam mengatur tingkah lakunya. Selain itu, Auditor harus independen dari setiap kewajiban atau independen dari pemilikan kepentingan dalam perusahaan yang diauditnya. Selanjutnya tujuan yang ingin dicapai dalam penelitian ini untuk mengetahui bagaimana pengaruh aturan etika dan independensi terhadap kepuasan kerja internal auditor pada BPKP Perwakilan Provinsi Lampung, penelitian ini menggunakan data primer, yaitu data yang diperoleh secara langsung dari sumber aslinya dengan kuesioner. Metode yang digunakan adalah nonprobability sampling, dalam penelitian ini sampel yang diambil berjumlah 70 responden. Hasil uji hipotesis menyatakan bahwa aturan etika secara parsial tidak berpengaruh terhadap kepuasan kerja dengan nilai -0,227<1.674 dan independensi berpengaruh terhadap kepuasan kerja dengan nilai 4.851>1.674. Secara simultan aturan etika dan independensi berpengaruh terhadap kepuasan kerja internal auditor dengan nilai 57.890 >nilai 2.78. kemudian besar sumbangan dari variabel independen (X) terhadap dependen (Y) yaitu pengaruhnya 69,4%, sedangkan sisanya 30,6% kepuasan kerja dipengaruhi oleh variabel lain diluar model regresi dalam penelitian ini. Hal ini menunjukkan bahwa aturan etika dan independensi sangat penting untuk diterapkan guna meningkatkan kemampuan auditor dalam melaksanakan tugas pokok dan fungsinya sebagai akuntan publik.
Perlindungan Hak Kekayaan Intelektual (HKI) bagi Usaha Kreatif Lokal dalam Mendukung Sektor Pariwisata
Authors: Seharja Sesde , Rusmini Andin
Published: November 2023

Tourism and the creative industry have an inseparable link, these two things are an emotional link between visitors and the tourist destinations they visit, namely in the form of souvenirs, as mementos to take home after traveling. Advances in digital technology have increased the distribution of information related to work and creativity so that the risk of work theft and copyright infringement is very vulnerable to occurring and this can be detrimental to creative industry players. This research uses qualitative methods with a literature approach in the form of laws, government regulations, articles and books that are relevant to the research topic. This research aims to provide an understanding of the importance of registering Intellectual Property Rights for creative industry to ensure the law protection of the intellectual property that has been created. The research results show that every creative industry player needs to register copyrighted works with the Directorate General of Intellectual Property. Apart from that, synergy is needed between the Government and the public in increasing awareness of creators or creative industry players to register copyrighted works as Intellectual Property Rights through regulations and facilities provided by the authorized government institution, namely the Directorate General of Intellectual Property, Ministry of Law and Rights. Indonesian Human Rights so that creative works receive legal protection.
Mini-Mobile Machine With Electric Control
Authors: Kenkishvili Roman , Dolidze Paata , Mshvildadze Pridon , Sharmiashvili Mikheil
Published: November 2023

The article discusses a mini-mobile machine of hybrid type designed in the Raphael Dvali Institute of Machine Mechanics. Mini-mobile machine is an intermediate link between two-wheel tractor and mini-tractor. The machine uses an electric system of control, which enables smoothly starting and stopping of machine, its maneuverability with independent changing rotation frequency and rotation direction of wheels, machine movement in forward and backward direction and braking. The machine is controlled by an operator with electrical panel both remotely and as well as sitting on the machine, which frees the operator from doing the hard work. Placing the operator directly on the machine increases adhesion power, allowing the machine to perform heavy agricultural operations. The construction of the machine provides for its operation with one or two active axels and is designed to perform various agricultural works. The represented construction of mini-mobile machine by simple alteration enables to work with one or two axles, to change the location of aggregates and units placed in the machine, and to equip it by different hanging equipment and devices. Thus, it is possible to build up the mobile machine with cross-country capability of different kind and purpose. In addition, it must be noted that the hybrid type power installation with an internal combustion engine, generators and electric drives was used for the first time for mobile vehicles of small mechanization in agriculture.
Las andanzas de Santiago en la nueva España y la imagen del indio: Santa María Chiconautla
Authors: Ontiveros Valdés Constanza
Published: November 2023

Santiago no es estático, adquirió diversas facetas de acuerdo a cada momento en el que se desenvolvió su leyenda e imagen. El presente trabajo analiza el papel que jugaron los indígenas en la iconografía jacobea novohispana a partir del estudio del conjunto escultórico de Santiago guerrero en Santa María Chiconautla, (siglo XVII, Ecatepec, México). En dicha pieza se retrata a indígenas junto con otra serie de elementos —un águila, una paloma, un nopal y glifos— completamente ajenos a las representaciones tradicionales de Santiago, por lo que esta pieza resulta atípica dentro de la iconografía jacobea. En este estudio se analiza la pieza de Chiconautla a la luz de las condiciones históricas y culturales de su producción. A su vez, se establecen comparaciones con otras imágenes novohispanas de Santiago que incluyen a indígenas como es el caso del relieve de Santiago en la Iglesia de Santiago en Tlatelolco (siglo XVII, Tlatelolco, México D.F.).
"Hrafnsdrápa": un poema cristiano islandés del siglo XIII y la peregrinación a Santiago
Authors: Barreiro Santiago
Published: November 2023

En este artículo buscamos analizar la peregrinación a Santiago mencionada en Hrafnsdrápa (“Encomio de Hrafn”), poema compuesto en Islandia durante la primera mitad del siglo XIII en honor al jefe local Hrafn Sveinbjarnarson. Comparando dicho poema con las obras en prosa sobre la vida de este jefe (las dos versiones de Hrafns saga), concluimos que el poema muestra un marcado énfasis en la devoción y habilidades de Hrafn, que lo distingue de otros líderes seculares islandeses de su época. Por otra parte, asociamos los motivos marítimos presentes en varias estrofas del drápa con una probable veneración de Hrafn por el apóstol, en tanto que patrón de los peregrinos. Por último, ofrecemos una traducción del poema a la lengua castellana en paralelo al texto en lengua nórdica antigua.
Les modèles transpyrénéens de la sculpture du premier chantier de Compostelle : imitation, présence réelle et usage de l’imaginaire
Authors: Le Deschault de Monredon Térence
Published: November 2023

El artículo propone analizar el origen de los modelos transpirenaicos empleados en la construcción de las primeras fases de la catedral de Santiago de Compostela (cabecera y crucero). El enfoque de dicho estudio se basa en dos puntos principales: por una parte, se intenta distinguir entre la “presencia real” de escultores franceses que proceden de las iglesias que sirvieron de referencia y la “imitación” de la escultura de esas mismas iglesias por parte de escultores externos a sus obras; por otra, sugerir las razones –vinculadas con la voluntad de adherirse a Roma y a las ideas de la reforma gregoriana– que indujeron al clero compostelano a elegir estos modelos en lugar de otros posibles.
Immigration, intégration et marqueurs sociaux au Manitoba : identité et rapport autre
Authors: Piquemal Nathalie , Zellama Faiçal , Sall Leyla , Rivard Étienne , Bolivar Bathélemy
Published: November 2023

Dans cet article, nous explorons les perceptions des nouveaux arrivants sur les obstacles et supports d’intégration en lien avec l’identité culturelle, les marqueurs sociolinguistiques minoritaires et les frontières identitaires instituées par la société eurocanadienne. Nous convoquons une combinaison de théories, en l’occurrence le multiculturalisme critique et l’approche de la délimitation différentielle des identités nationales, car elles sont pertinentes pour expliquer et analyser la persistance des inégalités des parcours migratoires en fonction des degrés d’altérisation des immigrants par la société eurocanadienne. À l’aide d’une approche qualitative comprenant des entrevues semi-dirigées auprès de 42 participants, nous analysons et interprétons les processus simultanés d’intégration de certaines catégories d’immigrants au sein de la fabrique sociale canadienne et d’exclusion et de relégation d’autres catégories à sa périphérie.
Autonomous metabolic reprogramming and oxidative stress characterize endothelial dysfunction in acute myocardial infarction
Authors: Zodda Erika , Tura-Ceide Olga , Mills Nicholas L , Tarragó-Celada Josep , Carini Marina , Thomson Timothy M , Cascante Marta
Published: November 2023

Compelling evidence has accumulated on the role of oxidative stress on the endothelial cell (EC) dysfunction in acute coronary syndrome. Unveiling the underlying metabolic determinants has been hampered by the scarcity of appropriate cell models to address cell-autonomous mechanisms of EC dysfunction. We have generated endothelial cells derived from thrombectomy specimens from patients affected with acute myocardial infarction (AMI) and conducted phenotypical and metabolic characterizations. AMI-derived endothelial cells (AMIECs) display impaired growth, migration, and tubulogenesis. Metabolically, AMIECs displayed augmented ROS and glutathione intracellular content, with a diminished glucose consumption coupled to high lactate production. In AMIECs, while PFKFB3 protein levels of were downregulated, PFKFB4 levels were upregulated, suggesting a shunting of glycolysis towards the pentose phosphate pathway, supported by upregulation of G6PD. Furthermore, the glutaminolytic enzyme GLS was upregulated in AMIECs, providing an explanation for the increase in glutathione content. Finally, AMIECs displayed a significantly higher mitochondrial membrane potential than control ECs, which, together with high ROS levels, suggests a coupled mitochondrial activity. We suggest that high mitochondrial proton coupling underlies the high production of ROS, balanced by PPP- and glutaminolysis-driven synthesis of glutathione, as a primary, cell-autonomous abnormality driving EC dysfunction in AMI.
Intramolecular feedback regulation of the LRRK2 Roc G domain by a LRRK2 kinase-dependent mechanism
Authors: Gilsbach Bernd K , Ho Franz Y , Riebenbauer Benjamin , Zhang Xiaojuan , Guaitoli Giambattista , Kortholt Arjan , Gloeckner Christian Johannes
Published: November 2023

The Parkinson’s disease (PD)-linked protein Leucine-Rich Repeat Kinase 2 (LRRK2) consists of seven domains, including a kinase and a Roc G domain. Despite the availability of several high-resolution structures, the dynamic regulation of its unique intramolecular domain stack is nevertheless still not well understood. By in-depth biochemical analysis, assessing the Michaelis–Menten kinetics of the Roc G domain, we have confirmed that LRRK2 has, similar to other Roco protein family members, a KM value of LRRK2 that lies within the range of the physiological GTP concentrations within the cell. Furthermore, the R1441G PD variant located within a mutational hotspot in the Roc domain showed an increased catalytic efficiency. In contrast, the most common PD variant G2019S, located in the kinase domain, showed an increased KM and reduced catalytic efficiency, suggesting a negative feedback mechanism from the kinase domain to the G domain. Autophosphorylation of the G1+2 residue (T1343) in the Roc P-loop motif is critical for this phosphoregulation of both the KM and the kcat values of the Roc-catalyzed GTP hydrolysis, most likely by changing the monomer–dimer equilibrium. The LRRK2 T1343A variant has a similar increased kinase activity in cells compared to G2019S and the double mutant T1343A/G2019S has no further increased activity, suggesting that T1343 is crucial for the negative feedback in the LRRK2 signaling cascade. Together, our data reveal a novel intramolecular feedback regulation of the LRRK2 Roc G domain by a LRRK2 kinase-dependent mechanism. Interestingly, PD mutants differently change the kinetics of the GTPase cycle, which might in part explain the difference in penetrance of these mutations in PD patients.
The function of juvenile–adult transition axis in female sexual receptivity of Drosophila melanogaster
Authors: Li Jing , Ning Chao , Liu Yaohua , Deng Bowen , Wang Bingcai , Shi Kai , Wang Rencong , Fang Ruixin , Zhou Chuan
Published: November 2023

Female sexual receptivity is essential for reproduction of a species. Neuropeptides play the main role in regulating female receptivity. However, whether neuropeptides regulate female sexual receptivity during the neurodevelopment is unknown. Here, we found the peptide hormone prothoracicotropic hormone (PTTH), which belongs to the insect PG (prothoracic gland) axis, negatively regulated virgin female receptivity through ecdysone during neurodevelopment in Drosophila melanogaster. We identified PTTH neurons as doublesex-positive neurons, they regulated virgin female receptivity before the metamorphosis during the third-instar larval stage. PTTH deletion resulted in the increased EcR-A expression in the whole newly formed prepupae. Furthermore, the ecdysone receptor EcR-A in pC1 neurons positively regulated virgin female receptivity during metamorphosis. The decreased EcR-A in pC1 neurons induced abnormal morphological development of pC1 neurons without changing neural activity. Among all subtypes of pC1 neurons, the function of EcR-A in pC1b neurons was necessary for virgin female copulation rate. These suggested that the changes of synaptic connections between pC1b and other neurons decreased female copulation rate. Moreover, female receptivity significantly decreased when the expression of PTTH receptor Torso was reduced in pC1 neurons. This suggested that PTTH not only regulates female receptivity through ecdysone but also through affecting female receptivity associated neurons directly. The PG axis has similar functional strategy as the hypothalamic–pituitary–gonadal axis in mammals to trigger the juvenile–adult transition. Our work suggests a general mechanism underlying which the neurodevelopment during maturation regulates female sexual receptivity.
Multiple origins of dorsal ecdysial sutures in trilobites and their relatives
Authors: Du Kun-sheng , Guo Jin , Losso Sarah R , Pates Stephen , Li Ming , Chen Ai-lin
Published: November 2023

Euarthropods are an extremely diverse phylum in the modern, and have been since their origination in the early Palaeozoic. They grow through moulting the exoskeleton (ecdysis) facilitated by breaking along lines of weakness (sutures). Artiopodans, a group that includes trilobites and their non-biomineralizing relatives, dominated arthropod diversity in benthic communities during the Palaeozoic. Most trilobites – a hyperdiverse group of tens of thousands of species - moult by breaking the exoskeleton along cephalic sutures, a strategy that has contributed to their high diversity during the Palaeozoic. However, the recent description of similar sutures in early diverging non-trilobite artiopodans means that it is unclear whether these sutures evolved deep within Artiopoda, or convergently appeared multiple times within the group. Here, we describe new well-preserved material of Acanthomeridion, a putative early diverging artiopodan, including hitherto unknown details of its ventral anatomy and appendages revealed through CT scanning, highlighting additional possible homologous features between the ventral plates of this taxon and trilobite free cheeks. We used three coding strategies treating ventral plates as homologous to trilobite-free cheeks, to trilobite cephalic doublure, or independently derived. If ventral plates are considered homologous to free cheeks, Acanthomeridion is recovered sister to trilobites, however, dorsal ecdysial sutures are still recovered at many places within Artiopoda. If ventral plates are considered homologous to doublure or non-homologous, then Acanthomeridion is not recovered as sister to trilobites, and thus the ventral plates represent a distinct feature to trilobite doublure/free cheeks.
Reactivation strength during cued recall is modulated by graph distance within cognitive maps
Authors: Kern Simon , Nagel Juliane , Gerchen Martin F , Gürsoy Çağatay , Meyer-Lindenberg Andreas , Kirsch Peter , Dolan Raymond J , Gais Steffen , Feld Gordon B
Published: November 2023

Declarative memory retrieval is thought to involve reinstatement of neuronal activity patterns elicited and encoded during a prior learning episode. Furthermore, it is suggested that two mechanisms operate during reinstatement, dependent on task demands: individual memory items can be reactivated simultaneously as a clustered occurrence or, alternatively, replayed sequentially as temporally separate instances. In the current study, participants learned associations between images that were embedded in a directed graph network and retained this information over a brief 8 min consolidation period. During a subsequent cued recall session, participants retrieved the learned information while undergoing magnetoencephalographic recording. Using a trained stimulus decoder, we found evidence for clustered reactivation of learned material. Reactivation strength of individual items during clustered reactivation decreased as a function of increasing graph distance, an ordering present solely for successful retrieval but not for retrieval failure. In line with previous research, we found evidence that sequential replay was dependent on retrieval performance and was most evident in low performers. The results provide evidence for distinct performance-dependent retrieval mechanisms, with graded clustered reactivation emerging as a plausible mechanism to search within abstract cognitive maps.