bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring Salivary Epithelial Dysfunction in Sjögren’s Disease
Authors: Noll Braxton , Beckman Micaela , Bahrani Mougeot Farah , Mougeot Jean-Luc
Published: May 2024

Sjögren’s Disease (SjD) is an autoimmune disease of the exocrine tissues. Etiological events result in the loss of epithelial homeostasis alongside extracellular matrix (ECM) destruction within the salivary and lacrimal glands, followed by immune cell infiltration. In this review, we have assessed the current understanding of epithelial–mesenchymal transition (EMT)-associated changes within the salivary epithelium potentially involved in salivary dysfunction and SjD pathogenesis. We performed a PubMed literature review pertaining to the determination of pathogenic events that lead to EMT-related epithelial dysfunction and signaling in SjD. Molecular patterns of epithelial dysfunction in SjD salivary glands share commonalities with EMT mediating wound healing. Pathological changes altering salivary gland integrity and function may precede direct immune involvement while perpetuating MMP9-mediated ECM destruction, inflammatory mediator expression, and eventual immune cell infiltration. Dysregulation of EMT-associated factors is present in the salivary epithelium of SjD and may be significant in initiating and perpetuating the disease. In this review, we further highlight the gap regarding mechanisms that drive epithelial dysfunction in salivary glands in the early or subclinical pre-lymphocytic infiltration stages of SjD.
In Search for Low-Molecular-Weight Ligands of Human Serum Albumin That Affect Its Affinity for Monomeric Amyloid β Peptide
Authors: Deryusheva Evgenia I. , Shevelyova Marina P. , Rastrygina Victoria A. , Nemashkalova Ekaterina L. , Vologzhannikova Alisa A. , Machulin Andrey V. , Nazipova Alija A. , Permyakova Maria E. , Permyakov Sergei E. , Litus Ekaterina A.
Published: May 2024

An imbalance between production and excretion of amyloid β peptide (Aβ) in the brain tissues of Alzheimer’s disease (AD) patients leads to Aβ accumulation and the formation of noxious Aβ oligomers/plaques. A promising approach to AD prevention is the reduction of free Aβ levels by directed enhancement of Aβ binding to its natural depot, human serum albumin (HSA). We previously demonstrated the ability of specific low-molecular-weight ligands (LMWLs) in HSA to improve its affinity for Aβ. Here we develop this approach through a bioinformatic search for the clinically approved AD-related LMWLs in HSA, followed by classification of the candidates according to the predicted location of their binding sites on the HSA surface, ranking of the candidates, and selective experimental validation of their impact on HSA affinity for Aβ. The top 100 candidate LMWLs were classified into five clusters. The specific representatives of the different clusters exhibit dramatically different behavior, with 3- to 13-fold changes in equilibrium dissociation constants for the HSA–Aβ40 interaction: prednisone favors HSA–Aβ interaction, mefenamic acid shows the opposite effect, and levothyroxine exhibits bidirectional effects. Overall, the LMWLs in HSA chosen here provide a basis for drug repurposing for AD prevention, and for the search of medications promoting AD progression.
Polymorphism of Genes Encoding Inflammatory Interleukins and the Risk of Anterior Cruciate Ligament Injury: A Systematic Review and Meta-Analysis
Authors: Lorenz Katarzyna , Mastalerz Andrzej , Cywińska Anna , Garbacz Aleksandra , Maculewicz Ewelina
Published: May 2024

Sport injuries, including the anterior crucial ligament rupture (ACLR) seem to be related to complex genetic backgrounds, including the genes responsible for inflammatory response. This review and meta-analysis investigated the contribution of the polymorphisms of genes encoding inflammatory cytokines and their receptors to the risk of ACLR. The scientific databases Science Direct, EBSCO host, Scopus, PubMed, and Google Scholar were screened (completed on 14 June 2023) according to the established inclusion/exclusion criteria (only fully accessible, original, human case–control studies written in English concerning the effect of interleukin genes’ polymorphisms on the occurrence of ACL injury were included) and statistical meta-analysis using R version 4.0.3 was performed. The PRISMA methodology was used to review articles. The review protocol was registered under the number CRD42024514316 in the Prospero database. Eighty-nine studies were identified and narrowed down to three original case–control studies used for the meta-analysis. The studies analyzed Polish, South African, and Swedish cohorts, altogether 1282 participants. The candidate polymorphisms indicated in the studies involved IL6 rs1800795, IL6R rs2228145 and IL1B rs16944. The systematic review showed the relationships between IL6 rs1800795 polymorphism and ACLR in the Polish subpopulation, and IL6R rs2228145 and IL1B rs16944 in the South African subpopulations. The meta-analysis revealed that the IL6 rs1800795 CG genotype was over-represented (OR = 1.30, 95% CI 1.02–1.66), while the CC genotype was under-represented (OR = 0.75, 95% CI 0.54–1.03) in ACLR subjects, but no significant impact of IL6R rs2228145 was shown. Additionally, a tendency of the IL1B rs16944 CT genotype to be protective (OR 0.89, 95% CI 0.70–1.14), while the TT to be a risk genotype (OR 1.19, 95% CI 0.84–1.68) was observed. Thus, the relationship between the interleukin receptor IL6R rs2228145 and ACLR risk was not confirmed. However, the impact of genes coding pleiotropic IL6 rs1800795 on the incidences of ACLR was clear and the effect of pro-inflammatory IL1B rs16944 was possible.
Enhanced Electroactive Phases of Poly(vinylidene Fluoride) Fibers for Tissue Engineering Applications
Authors: Zaszczyńska Angelika , Gradys Arkadiusz , Ziemiecka Anna , Szewczyk Piotr K. , Tymkiewicz Ryszard , Lewandowska-Szumieł Małgorzata , Stachewicz Urszula , Sajkiewicz Paweł Ł.
Published: May 2024

Nanofibrous materials generated through electrospinning have gained significant attention in tissue regeneration, particularly in the domain of bone reconstruction. There is high interest in designing a material resembling bone tissue, and many scientists are trying to create materials applicable to bone tissue engineering with piezoelectricity similar to bone. One of the prospective candidates is highly piezoelectric poly(vinylidene fluoride) (PVDF), which was used for fibrous scaffold formation by electrospinning. In this study, we focused on the effect of PVDF molecular weight (180,000 g/mol and 530,000 g/mol) and process parameters, such as the rotational speed of the collector, applied voltage, and solution flow rate on the properties of the final scaffold. Fourier Transform Infrared Spectroscopy allows for determining the effect of molecular weight and processing parameters on the content of the electroactive phases. It can be concluded that the higher molecular weight of the PVDF and higher collector rotational speed increase nanofibers’ diameter, electroactive phase content, and piezoelectric coefficient. Various electrospinning parameters showed changes in electroactive phase content with the maximum at the applied voltage of 22 kV and flow rate of 0.8 mL/h. Moreover, the cytocompatibility of the scaffolds was confirmed in the culture of human adipose-derived stromal cells with known potential for osteogenic differentiation. Based on the results obtained, it can be concluded that PVDF scaffolds may be taken into account as a tool in bone tissue engineering and are worth further investigation.
ROS-Responsive PLGA-NPs for Co-Delivery of DTX and DHA for Colon Cancer Treatment
Authors: Cassano Roberta , Trombino Sonia , Curcio Federica , Sole Roberta , Calviello Gabriella , Serini Simona
Published: May 2024

The aim of this work was to evaluate the antineoplastic effect of newly synthesized nanoparticles based on poly(lactic-co-glycolic acid) (PLGA) alone or PLGA esterified with 2,2′-[propane-2,2-diylbis (thio)] diacetic acid (TKL), loaded with docetaxel (DTX) and/or docosahexaenoic acid (DHA), as innovative site-specific therapeutic carriers. The obtained materials were characterized by FT-IR and 1H-NMR, while the dimensional analysis of the nanoparticles obtained was performed by Dynamic Light Scattering. The encapsulation efficiency of the nanoparticles was evaluated, and in vitro skin permeation tests were also performed. The antitumor activity of the nanomaterial was studied in the human adenocarcinoma HCT116 cell line. In particular, viability tests in bidimensional culture, as well as in tumor spheroids, were conducted. The use of these nanocarriers could facilitate the stable and efficient delivery of DTX and DHA through the upper segments of the gastrointestinal tract to the colon. In addition, the presence of the ROS-sensitive 2,2′-[propane-2,2-diylbis (thio)] diacetic acid in their matrix should promote the site-specific release of DTX in the tumor mass, where high levels of reactive oxygen species could be found.
Epileptic Seizure Detection from Decomposed EEG Signal through 1D and 2D Feature Representation and Convolutional Neural Network
Authors: Das Shupta , Mumu Suraiya Akter , Akhand M. A. H. , Salam Abdus , Kamal Md Abdus Samad
Published: May 2024

Electroencephalogram (EEG) has emerged as the most favorable source for recognizing brain disorders like epileptic seizure (ES) using deep learning (DL) methods. This study investigated the well-performed EEG-based ES detection method by decomposing EEG signals. Specifically, empirical mode decomposition (EMD) decomposes EEG signals into six intrinsic mode functions (IMFs). Three distinct features, namely, fluctuation index, variance, and ellipse area of the second order difference plot (SODP), were extracted from each of the IMFs. The feature values from all EEG channels were arranged in two composite feature forms: a 1D (i.e., unidimensional) form and a 2D image-like form. For ES recognition, the convolutional neural network (CNN), the most prominent DL model for 2D input, was considered for the 2D feature form, and a 1D version of CNN was employed for the 1D feature form. The experiment was conducted on a benchmark CHB-MIT dataset as well as a dataset prepared from the EEG signals of ES patients from Prince Hospital Khulna (PHK), Bangladesh. The 2D feature-based CNN model outperformed the other 1D feature-based models, showing an accuracy of 99.78% for CHB-MIT and 95.26% for PHK. Furthermore, the cross-dataset evaluations also showed favorable outcomes. Therefore, the proposed method with 2D composite feature form can be a promising ES detection method.
Nanopore-Based Surveillance of Leishmania Parasites in Culicoides Latrielle (Diptera: Ceratopogonidae) Caught from the Affected Community and Tham Phra Cave in Chiang Rai Province, the Endemic Area of Leishmaniasis in Northern Thailand
Authors: Ampol Rinnara , Somwang Puckavadee , Khositharattanakool Pathamet , Promrangsee Chulaluk , Pataradool Thanapat , Tepboonreung Piyapat , Siriyasatien Padet , Preativatanyou Kanok
Published: May 2024

In this research, we elucidated the species composition of Culicoides biting midges, infection prevalence, and genetic diversity of Leishmania parasites circulating in the affected community in Chiang Rai Province, being the most endemic area in Northern Thailand. A total of 146 parous and gravid females, belonging to at least twelve Culicoides species in five subgenera and one species group, were trapped from three collection sites with an overall Leishmania prevalence of 26.7% (39/146). Leishmania was detected, using ITS1-PCR, in C. mahasarakamense (15), C. guttifer (11), C. (Trithecoides) spp. (8), C. jacobsoni (2), C. oxystoma (2), and C. orientalis (1). The evidence of Leishmania infection in these last five species represents new records in Northern Thailand. Given a high infection rate in cavernicolous specimens, this indicates an increased risk of parasite exposure when visiting the cave. Using the nanopore amplicon sequencing, L. martiniquensis was ubiquitously identified in all positives, and more than half of these were also co-infected with L. orientalis. The genetic diversity analysis revealed 13 and 17 unique haplotypes for L. martiniquensis and L. orientalis, respectively. Higher haplotype diversity and relatively low nucleotide diversity were observed in both parasite populations, suggesting recent population divergence. Neutrality tests (Tajima’s D and Fu and Li’s D) showed to be significantly negative, indicating rapid population growth or a selective sweep. Moreover, dominant haplotypes of both Leishmania species were 100% identical to those in all leishmaniasis patients previously reported from Northern Thailand, strongly supporting the imperative role of Culicoides spp. in disease transmission. Essentially, this research provides the first entomological surveillance data representing the sympatric existence, transmission dynamics, and genetic complexity of two autochthonous Leishmania (Mundinia) parasites in several Culicoides species in the endemic area of Northern Thailand. This would contribute to a more complete understanding of the epidemiology of vector infection and facilitate the development of vector control programs to effectively reduce the transmission of this neglected tropical disease in endemic areas of Northern Thailand.
Association between Abdominal Aortic Calcification and Coronary Heart Disease in Essential Hypertension: A Cross-Sectional Study from the 2013–2014 National Health and Nutrition Examination Survey
Authors: He Lan , Li Xu , Shen E , He Yong-Ming
Published: May 2024

Background: This study aimed to investigate the association between abdominal aortic calcification (AAC) and coronary heart disease (CHD) in essential hypertension (EH). Methods: This study included patients diagnosed with EH during the 2013–2014 NHANES survey cycle. The study cohort was categorized into the following four groups based on their AAC-24 score: no AAC (0); mild AAC (1–4); moderate AAC (5–15); and severe AAC (16–24). Logistic regression models were used to assess the association between AAC and CHD. Restricted cubic spline curves (RCS) were used to explore possible nonlinear relationships between AAC and CHD. Results: The prevalence of CHD was found to be higher in the moderate AAC and severe AAC groups than in the group without AAC (40.1% versus 30.9%, 47.7% versus 30.9%). On a continuous scale, the fully adjusted model showed a 7% increase in the risk of CHD prevalence per score increase in AAC [OR (95% CI) = 1.07 (1.03–1.11)]. On a categorical scale, the fully adjusted model showed the risk of CHD prevalence in EH patients with moderate AAC and severe AAC was 2.06 (95%CI, 1.23–3.45) and 2.18 (1.09–5.25) times higher than that in patients without AAC, respectively. The RCS curve suggested a dose-response linear relationship between AAC and CHD. Conclusion: These findings highlight that in patients with EH, a higher severity of AAC is associated with a higher risk of CHD prevalence.
Application and Advantages of the Trans-Unco-Discal (TUD) Approach for Cervical Spondylotic Myelopathy and Radiculopathy: Classification and Modification of Surgical Technique Based on the Location of Spinal Cord and/or Nerve Root Compression
Authors: Nishikawa Misao , Naito Kentaro , Yoshimura Masaki , Yamagata Toru , Iseda Keiichi , Hara Mitsuhiro , Ikuno Hiromichi , Ohata Kenji , Goto Takeo
Published: May 2024

Purpose: We assess the application and advantages of modifying the trans-unco-discal (TUD) approach which we underwent for cervical myelo-radiculopathy. We present the surgical techniques of the modified TUD approach. Materials and Methods: The material was 180 cases where anterior cervical decompression (ACD) was performed by the modified TUD approach. We classified the material into four groups based on the location of the nerve root and/or spinal cord compression: I, compression of the root at intervertebral foramen (IVF); II, compression of the posterior margin of the vertebral body; III, compression of the IVF and posterior margin of the vertebral body; IV, compression of the bilateral IVF and posterior margin of the vertebral body. We applied the modified TUD approach to these four types. We present the surgical procedures and techniques for the modified TUD approach. The Japanese orthopedic association (JOA) score and neuroradiological alignment were examined. Results: The improvement rate of the JOA score was 78.4% at 6 months post-surgery and 77.5% in the most recent examinations. By the modified TUD approach, compressive lesions of the spinal cord and/or nerve roots were removed, and good alignment was acquired and sustained. Conclusions: ACD by the modified TUD approach safely achieved appropriate decompression for the spinal cord and/or nerve roots, and the patients had a high improvement rate and good alignment. Complications were less common than with other surgical procedures. If the TUD approach and endoscopic approaches can be combined, their application to new area is anticipated.
Understanding the Pathophysiology of Preeclampsia: Exploring the Role of Antiphospholipid Antibodies and Future Directions
Authors: Mitranovici Melinda-Ildiko , Chiorean Diana Maria , Moraru Raluca , Moraru Liviu , Caravia Laura , Tiron Andreea Taisia , Craina Marius , Cotoi Ovidiu Simion
Published: May 2024

Preeclampsia (PE) is a hypertensive disorder in pregnancy associated with significant fetal and maternal complications. Antiphospholipid syndrome (APS) is an acquired form of thrombophilia characterized by recurrent venous or arterial thrombosis and obstetric complications that significantly increases morbidity and mortality rates. While preeclampsia may not be the most prevalent obstetric complication in APS, it significantly impacts the long-term health of both mother and child. The treatment of preeclampsia in antiphospholipid syndrome is different from the treatment of preeclampsia as an independent disease. Despite current treatments involving anticoagulants, antiplatelet agents, and antihypertensive drugs, obstetric complications may persist, underscoring the need for cohesive management and effective treatments. The objective of our review is to briefly present knowledge about the physiopathology of preeclampsia and the role of antiphospholipid antibodies in this process. Based on the existing literature, our review aims to identify future directions in molecular pathology toward the discovery of biomarkers and targeted treatments. The application of multidisciplinary approaches and prognostic models, including new biomarkers, could be beneficial in the prediction of PE.
Serial Cardiac Magnetic Resonance Imaging in Patients with Mitral Valve Prolapse—A Single-Center Retrospective Registry
Authors: Blondeel Maarten , L’Hoyes Wouter , Robyns Tomas , Verbrugghe Peter , De Meester Pieter , Dresselaers Tom , Masci Pier Giorgio , Willems Rik , Bogaert Jan , Vandenberk Bert
Published: May 2024

Background: Mitral valve prolapse (MVP) and mitral annular disjunction (MAD) are common valvular abnormalities that have been associated with ventricular arrhythmias (VA). Cardiac magnetic resonance imaging (CMR) has a key role in risk stratification of VA, including assessment of late gadolinium enhancement (LGE). Methods: Single-center retrospective analysis of patients with MVP or MAD who had >1 CMR and >1 24 h Holter registration available. Data are presented in detail, including evolution of VA and presence of LGE over time. Results: A total of twelve patients had repeated CMR and Holter registrations available, of which in four (33%) patients, it was conducted before and after minimal invasive mitral valve repair (MVR). After a median of 4.7 years, four out of eight (50%) patients without surgical intervention had new areas of LGE. New LGE was observed in the papillary muscles and the mid to basal inferolateral wall. In four patients, presenting with syncope or high-risk non-sustained ventricular tachycardia (VT), programmed ventricular stimulation was performed and in two (50%), sustained monomorphic VT was easily inducible. In two patients who underwent MVR, new LGE was observed in the basal inferolateral wall of which one presented with an increased burden of VA. Conclusions: In patients with MVP and MAD, repeat CMR may show new LGE in a small subset of patients, even shortly after MVR. A subgroup of patients who presented with an increase in VA burden showed new LGE upon repeat CMR. VA in patients with MVP and MAD are part of a heterogeneous spectrum that requires further investigation to establish risk stratification strategies.
Prevalence of Diabetes Mellitus and Clinical Differences in Patients with Severe Osteoporosis and Fragility Fractures
Authors: Nardone Isabella , Antonelli Rossella , Zaccaria Simona , Wolde Sellasie Sium , Falcone Stefania , Pecchioli Chiara , Giurato Laura , Uccioli Luigi
Published: May 2024

Background: Diabetes mellitus (DM) and osteoporosis are two of the most widespread metabolic diseases in the world. The aim of this study is to investigate the prevalence of DM among patients affected by osteoporosis and fragility fractures, and to search for differences in clinical characteristics. Methods: This is a single-center retrospective, case–controlled study. A total of 589 patients attending CTO Bone Unit between 2 January 2010 and 31 May 2023, due to osteoporosis and fragility fractures, were divided into two groups, according to the diagnosis of DM. The clinical and bone characteristics of patients were compared. Results: Prevalence of DM was 12.7%. Compared to patients without DM, the median age at the time of first fracture was similar: 72 years ± 13.5 interquartile range (IQR) vs. 71 years ± 12 IQR; prevalence of combination of vertebral and hip fractures was higher (p = 0.008), as well as prevalence of males (p = 0.016). Bone mineral density (BMD) at all sites was higher in DM group; trabecular bone score (TBS), instead, was significantly lower (p < 0.001). Conclusions: Patients with fragility fractures and DM more frequently show combination of major fractures with higher BMD levels. In these patients, TBS could be a better indicator of bone health than BMD and, therefore, might be used as a diagnostic tool in clinical practice.
3D-Volumetric Shunt Measurement for Detection of High-Risk Esophageal Varices in Liver Cirrhosis
Authors: Glückert Kathleen , Decker Alexandra , Meier Jörn Arne , Nowak Sebastian , Sanoubara Feras , Gödiker Juliana , Reinartz Groba Sara Noemi , Kimmann Markus , Luetkens Julian A. , Chang Johannes , Sprinkart Alois M. , Praktiknjo Michael
Published: May 2024

Background and Objectives: Esophageal varices (EV) and variceal hemorrhages are major causes of mortality in liver cirrhosis patients. Detecting EVs early is crucial for effective management. Computed tomography (CT) scans, commonly performed for various liver-related indications, provide an opportunity for non-invasive EV assessment. However, previous CT studies focused on variceal diameter, neglecting the three-dimensional (3D) nature of varices and shunt vessels. This study aims to evaluate the potential of 3D volumetric shunt-vessel measurements from routine CT scans for detecting high-risk esophageal varices in portal hypertension. Methods: 3D volumetric measurements of esophageal varices were conducted using routine CT scans and compared to endoscopic variceal grading. Receiver operating characteristic (ROC) analyses were performed to determine the optimal cutoff value for identifying high-risk varices based on shunt volume. The study included 142 patients who underwent both esophagogastroduodenoscopy (EGD) and contrast-enhanced CT within six months. Results: The study established a cutoff value for identifying high-risk varices. The CT measurements exhibited a significant correlation with endoscopic EV grading (correlation coefficient r = 0.417, p < 0.001). A CT cutoff value of 2060 mm3 for variceal volume showed a sensitivity of 72.1% and a specificity of 65.5% for detecting high-risk varices during endoscopy. Conclusions: This study demonstrates the feasibility of opportunistically measuring variceal volumes from routine CT scans. CT volumetry for assessing EVs may have prognostic value, especially in cirrhosis patients who are not suitable candidates for endoscopy.
Osteonecrosis of the Jaw Associated with Bisphosphonates Infusion for Treatment of Plasma Cell Myeloma—A Retrospective Observational Study of Northern Portuguese Population
Authors: Ferreira Sara Sousa , Amaral José Barbas do , Pacheco José Júlio , Salazar Filomena , Monteiro Luís
Published: May 2024

Objectives: To verify medication-related osteonecrosis of the jaw (MRONJ) frequency among patients with plasma cell myeloma (PCM) that had been treated with bisphosphonates, to identify predisposing factors that could influence the development of osteonecrosis. Methods: This observational retrospective study was performed at the Department of Hematology of Hospital Center of Porto (CHUP), Portugal. Results: The study population (n = 112) had a 15.2% (n = 17) prevalence of osteonecrosis. Clinically, bone exposure was the most frequently observed sign, present in 100% (n = 17) of the patients, followed by inflammation in 82.4% (n = 14), orofacial pain in 70.6% (n = 12), suppuration in 47.1% (n = 8), and intra or extra-oral fistula in 17.6% (n = 3) of the cases. The most frequent triggering local factor was dental extraction (82.4%). There was a dependence between the presence of extractions and the development of MRONJ (p < 0.001) but not with the time elapsed from the initiation of infusions with BPs and dental extractions (p = 0.499). In the sample of patients with multiple myeloma (MM), 13.8% were found to be more likely to develop MRONJ after an extraction. Conclusions: The most common local predisposing factor was dental extraction. No dependence was observed between the development of osteonecrosis and the time elapsed from the beginning of treatment with bisphosphonates infusions to surgical procedures.
Exploring Risk Factors for Predicting 30-Day Postoperative Morbidity in Musculoskeletal Tumor Surgery
Authors: Heesen Philip , Elyes Maria , Domanski Jan , Schelling Georg , Könneker Sören , Fuchs Bruno
Published: May 2024

Background: This study investigates the risk factors associated with postoperative complications in musculoskeletal tumor surgeries and evaluates the impact of benchmarking in enhancing surgical outcomes. Methods: Conducted at a tertiary referral center, this retrospective analysis included 196 patients who underwent surgeries for various musculoskeletal tumors, ranging from soft tissue to bone sarcomas. Patient and tumor characteristics, along with surgical interventions and outcomes, were comprehensively assessed using the Charlson Comorbidity Index and the Clavien-Dindo classification. Results: Key findings indicate that surgical reconstruction, ASA 3 status, bone tumor presence, and the need for multiple erythrocyte transfusions significantly increase postoperative morbidity. Notably, no significant correlation was found between the Charlson Comorbidity Index scores and the occurrence or severity of complications, challenging the utility of this index in predicting short-term surgical outcomes. Conclusions: This study highlights the importance of tailored surgical approaches and emphasizes rigorous preoperative assessments to mitigate risks and enhance patient care. Despite its insights, limitations include its retrospective nature and single-center scope, suggesting a need for broader, multicenter studies to generalize findings. Overall, our results underscore the necessity of integrating clinical assessments with benchmarking data to optimize outcomes in the complex field of musculoskeletal tumor surgery.
Preliminary Study on Pulse Wave Changes in Patients with Inflammatory Arthropathies Treated with bDMARDs
Authors: Gasparotto Michela , Di Pierro Giuliano , Toffoli Barbara , Grillo Andrea , Bressan Marco , Fiorentin Marco , Di Luozzo Lorenzo , Fischetti Fabio , Zen Margherita , Fabris Bruno , Bernardi Stella , Tomietto Paola
Published: May 2024

Background: Patients with inflammatory arthropathies exhibit an increased cardiovascular disease (CVD) risk as compared to the general population, which is not fully quantified by the conventional CVD risk scores. Biotechnological disease-modifying drugs (bDMARDs) have proved beneficial to reduce the overall CVD risk in these patients, although CVD remains a major cause of increased mortality. Since it has been shown that pulse wave parameters and in particular carotid–femoral pulse wave velocity (cfPWV) are predictors of CVD risk, the aim of this study was to evaluate their changes in patients with inflammatory arthropathies before and after bDMARD therapy. Methods: Pulse wave parameters were evaluated with applanation tonometry in patients with ankylosing spondylitis (AS), psoriatic arthritis (PsA), and rheumatoid arthritis (RA), before and after two years of bDMARD therapy. Results: At baseline, cfPWV was significantly associated with age (p < 0.001) and, among pulse wave parameters, the subendocardial viability ratio was negatively associated with C-reactive protein (CRP) (p = 0.04) and the HAQ-disability index (p = 0.03). At baseline, PsA patients showed a higher percentage of male subjects, higher CRP, and the highest cfPWV values (p = 0.048). After two years, pulse wave parameters improved in the AS and RA groups, but not in the PsA group. Conclusions: Our data confirm that pulse wave parameters are potentially reversible after bDMARD therapy, as they improved in AS and RA patients. In PsA patients, there were no changes, which may be due to the higher percentage of male subjects and higher baseline cfPWV values.
Endothelial Dysfunction as a Key Link between Cardiovascular Disease and Frailty: A Systematic Review
Authors: Calila Hakan , Bălășescu Elena , Nedelcu Roxana Ioana , Ion Daniela Adriana
Published: May 2024

Background: Frailty is increasingly recognized as a significant health concern, particularly due to its association with cardiovascular pathologies. This study aims to examine how vascular endothelial dysfunction, a known premorbid stage in the pathophysiology of cardiovascular diseases, contributes to the link between cardiovascular illness and frailty. Methods: The inclusion criteria allowed us to focus on original clinical research articles published in English between January 2014 and January 2024, which reported quantitative assessments of the relationship between frailty and vascular endothelial dysfunction. Excluded from the study were systematic literature reviews, meta-analyses, editorials, conference articles, theses, methodological articles, and studies using animal or cell culture models. Searches were conducted of electronic databases, including Scopus, ScienceDirect, and Medline, up to 22 January 2024. The risk of bias was assessed using the Joanna Briggs Institute’s critical appraisal tools. The methods used to present and synthesize the results involved data extraction and categorization based on biomolecular and clinical findings of endothelial dysfunction. Results: Following the application of the inclusion and exclusion criteria, a total of 29 studies were identified. Vascular endothelial dysfunction was associated with increased frailty phenotypes, and we also identified SGLT-2 inhibitors’ potential role as an anti-fragility treatment that affects endothelial dysfunction. This study found that the physical and biomolecular markers of endothelial dysfunction are associated with frailty measures and have predictive value for incident frailty. Furthermore, some studies have shown inflammation to have an impact on endothelial dysfunction and frailty, and an innovative age-related chronic inflammation measure has been proven to predict frailty scores. Conclusions: The current evidence suggests an association between endothelial dysfunction and frailty, highlighting the need for further research to elucidate the underlying mechanisms.
Chemical and Thermal Analysis of Fly Ash-Reinforced Aluminum Matrix Composites (AMCs)
Authors: Nordin Siti Syazwani , Mhd Noor Ervina Efzan , Chockalingam Palanisamy
Published: May 2024

Fly ash has been utilized as a reinforcing material in the production of aluminum matrix composites, and in this investigation, Al-Si (LM6) fly ash composites were fabricated using the compocasting method. Various compositions of fly ash were incorporated into the samples (4, 5 and 6 wt%), and the preparation temperature ranged from 560 to 800 °C. This study investigated the thermal (CTE and DTA) and chemical properties (XRD) of fly ash reinforcement and the aluminum melt in the composites. The results revealed that composites with 5 wt% of fly ash exhibited the lowest CTE value compared to those with 4 and 6 wt%. This observation was corroborated by XRD analysis, indicating a reaction between the fly ash particles and the aluminum melt. However, the DTA analysis did not find a significant impact of the addition of fly ash on the melting temperature of the prepared composites. In contrast, this study identified and investigated the existence of reaction effects between the fly ash particles and the aluminum melt.
Numerical Simulations of Thermoacoustic Binary Gas Mixture Batch Separation
Authors: Kouta Ahmad , Vít Tomáš , Dančová Petra
Published: May 2024

In this paper, 2D simulations were carried out to prove the potential of thermoacoustic technology in separating a binary gas mixture. A 2D model of a gas mixture separator was developed, including a loudspeaker responsible for producing acoustic waves in the separation pipe. As a result of the imposed sound waves propagating inside the separator, main parameters including pressure, temperature, and density undergo oscillations, which in turn drive the light and heavy gas components in opposite directions. Through time, one end of the separator is enriched with the light component while the other end is enriched with the heavy one. Simulations were all performed using ANSYS Fluent. The aim was to separate an ideal gas mixture of Helium–Argon and study the impact of different parameters on the separation process.
An Empirical Test of the Concept of the Adaptively Intelligent Attitude
Authors: Sternberg Robert J. , Soleimani Dashtaki Arezoo , Baydil Banu
Published: May 2024

This study provides an empirical test of a previously proposed assertion that intelligence as adaptation has an attitudinal as well as an ability component. The ability component deals with what the basic knowledge and skills are that underlie intelligence, and how much of each one an individual has. The attitudinal component deals with how an individual chooses to deploy the abilities they have. In other words, to what use are the abilities put? It is argued that it is impossible fully to separate the measurement of the ability component from the attitudinal one. In a diverse population, even taking an intelligence test will show itself to involve an attitude toward the test, which may enhance or detract from performance, as when one sees the test as irrelevant or harmful to one’s life, or as a sociocultural misfit to one’s life experience. To succeed, people need not only to have abilities, but attitudes that put those abilities to effective use to accomplish individuals’ life goals. In the study, we found that intelligent attitudes are related, but non-identical, to germane constructs, such as wisdom, the need for cognition, creativity, and openness to experience. Scores on the attitudinal measure were not related to scores on tests of fluid intelligence and academic abilities/achievement. Thus, the range of attitudes regarding how to deploy intelligence can vary over ability levels.
Research on the Influencing Factors of AUV Hovering Control in Null-Speed State
Authors: Wang Jianguo , Jiang Chunmeng , Wan Lei , Zhou Yimei , Hu Gangyi , Cheng Xide , Wu Gongxing
Published: May 2024

Intelligent underwater vehicles hover by way of a hovering control system. To provide design inputs and maneuver guidance, this study focused on the characteristics of intelligent underwater vehicles during hovering control with the propulsion system shut down, established a mathematical model of hovering control and determined injection and drainage functions based on optimal control theory. From analysis simulation experiments, the influence laws of control parameters, control timing and rate of injection and drainage control upon hovering control were deduced. It is proposed that, at the time of control parameter selection, the continuous injection and drainage rate at each time should be reduced as far as possible to relieve the demand on the volume of the reservoir when the requirement of depth control accuracy has been satisfied. In addition, the injection and drainage control should initiate when depth changes exceed 0.5 m. Suggestions are included on the minimum injection and drainage rate required for different initial disturbances. The proposed suggestions guide the design of hovering control systems and hovering control over intelligent underwater vehicles.
A Time-Domain Wavenumber Integration Model for Underwater Acoustics Based on the High-Order Finite Difference Method
Authors: Xu Xiang , Liu Wei , Xu Guojun
Published: May 2024

Simulating the acoustic field excited by pulse sound sources holds significant practical value in computational ocean acoustics. Two primary methods exist for modeling underwater acoustic propagation in the time domain: the Fourier synthesis technique based on frequency decomposition and the time-domain underwater acoustic propagation model (TD-UAPM). TD-UAPMs solve the wave equation in the time domain without requiring frequency decomposition, providing a more intuitive explanation of the physical process of sound energy propagation over time. However, time-stepping numerical methods can accumulate numerical errors, making it crucial to improve the algorithm’s accuracy for TD-UAPMs. Herein, the time-domain wavenumber integration model SPARC was improved by replacing the second-order finite element method (FEM) with the high-order accuracy finite difference method (FDM). Furthermore, the matched interface and boundary (MIB) method was used to process the seabed more accurately. The improved model was validated using three classic underwater acoustic benchmarks. By comparing the acoustic solutions obtained using the FDM and the FEM, it is evident that the improved model requires fewer grid points while maintaining the same level of accuracy, leading to lower computational costs and faster processing compared to the original model.
Experimental and Numerical Prediction of Slamming Impact Loads Considering Fluid–Structure Interactions
Authors: Lu Tao , Wang Jiaxia , Liu Kun , Zhao Xiaochao
Published: May 2024

Slamming impacts on water are common occurrences, and the whipping induced by slamming can significantly increase the structural load. This paper carries out an experimental study of the water entry of rigid wedges with various deadrise angles. The drop height and deadrise angle are parametrically varied to investigate the effect of the entry velocity and wedge shape on the impact dynamics. A two-way coupled approach combing CFD method software STAR-CCM+12.02.011-R8 and the FEM method software Abaqus 6.14 is presented to analyze the effect of structural flexibility on the slamming phenomenon for a wedge and a ship model. The numerical method is validated through the comparison between the numerical simulation and experimental data. The slamming pressure, free surface elevation, and dynamic structural response, including stress and strain, in particular, are presented and discussed. The results show that the smaller the inclined angle at the bottom of the wedge-shaped body, the faster the entry speed into the water, resulting in greater impact pressure and greater structural deformation. Meanwhile, studies have shown that the bottom of the bow is an area of concern for wave impact problems, providing a basis for the assessment of ship safety design.
Study of Underwater Large-Target Localization Based on Binocular Camera and Laser Rangefinder
Authors: Xu Wenbo , Zheng Xinhui , Tian Qiyan , Zhang Qifeng
Published: May 2024

Currently, for underwater close-range large-target localization, visual localization techniques fail since large targets completely occupy the camera’s field of view at ultraclose ranges. To address the issue, a multi-stage optical localization method combining a binocular camera and a single-point laser rangefinder is proposed in this paper. The proposed method comprises three parts. First, the imaging model of the underwater camera is modified, and a laser rangefinder is used to further correct the underwater calibration results of the binocular camera. Second, YOLOv8 is applied to recognize the targets to prepare for target localization. Third, extrinsic calibration of the binocular camera and laser rangefinder is performed, and a Kalman filter is employed to fuse the target position information measured by the binocular camera and laser rangefinder. The experimental results show that, compared with using a binocular camera alone, the proposed method can accurately and stably locate the target at close ranges with an average error of only 2.27 cm, without the risk of localization failure, and reduces binocular localization error by 90.57%.
Lower Limits of Petrophysical Properties Allowing Natural Gas Accumulation in Marine Sandstones: An Example from the Qiongdongnan Basin, Northern South China Sea
Authors: Li Chao , Guo Shuai , Zhou Qianshan , Xu Chaochao , Chen Guojun
Published: May 2024

The lower limits of petrophysical properties for an effective reservoir are among the key parameters for assessing hydrocarbon reserves and are therefore directly related to hydrocarbon exploration and development strategies. However, the lower limits for marine sandstone gas reservoirs are still not clear and the impact factors also remain to be discussed. This study analysed the lower petrophysical property limits of an effective sandstone reservoir in the Qiongdongnan Basin using porosity, permeability and gas testing. The results showed that the lower porosity and permeability limits of effective reservoirs developed in the deltas are 8.9% and 1.2 × 10−3 μm2, respectively, and 11.3% and 4.0 × 10−3 μm2 in the submarine canyons and fans, respectively. Sedimentary facies, sediment transport distance, grain size and burial depth of sandstone significantly influence the lower physical property limits. The lower porosity and permeability limits increase with the increase in sediment transport distance as well as the decrease in sandstone grain size and burial depth. Sediment sources and sedimentary facies determine whether sandstone can become an effective reservoir in the Qiongdongnan Basin. Specifically, the sediment source dramatically influences the petrophysical properties of sandstone. The sandstone sourced from the Red River has higher porosity and permeability, followed by the sandstone sourced from the Hainan Uplift, and the sandstone sourced from the palaeo-uplift within the basin has the lowest porosity and permeability. The feldspar dissolution by CO2 and organic acid is the primary formation mechanism of the effective reservoir in the Lingshui Formation, whereas the dissolution of glauconite is more common in the sandstone reservoirs of the Sanya and Meishan formations.
Laser In Situ U–Pb Isotope Dating of Carbonate Rocks in Weijia Guyot in the Western Pacific Ocean and Its Geological Significance
Authors: Wei Zhenquan , Ma Jinfeng , He Gaowen , Zhong Lifeng , Zhang Limin , Zhao Bin
Published: May 2024

Shallow-water carbonate rocks constitute a crucial component of large guyots, arising in distinct environments and harboring valuable insights into the evolutionary stages of seamount islands as well as the tectonic conditions of the underlying oceanic plate. Laser Ablation Multi-Collector Inductively Coupled Plasma Mass Spectrometry (LA-MC-ICP-MS) was used to conduct in situ U–Pb isotope dating of carbonate minerals with low uranium content collected from Weijia Guyot. This dating approach yielded crucial evidence for the vertical development of the seamount. Our study indicates that shallow-water carbonate rocks in Weijia Guyot had a temporal range between 91 My and 137 My. The carbonate rocks underwent two growth phases, Hauterivian to Barremian and Cenomanian to Turonian, with a hiatus of approximately 20 My. Since the Hauterivian age, the shield volcano of Weijia Guyot is essentially complete, with its seamount top exposed at or near sea level and receiving its first stage of shallow-water carbonate sedimentation. Based on the dating of both shallow-water carbonate rocks and hawaiite within the Weijia Guyot, it is inferred that approximately 10 My elapsed from shield-building volcanism to late alkalic volcanism. During the Turonian age, the main reason for the second phase of shallow-water carbonate rocks in the seamounts was the regional tectonic uplift triggered by the drift of the Weijia Guyot along with the Pacific Plate toward the Society hotspot.
A Study of Adaptive Threshold Based on the Reconstruction Model for Marine Systems and Their Equipment Failure Warning
Authors: Duan Xuxu , Gao Zeyu , Qiao Zhenxing , Du Taili , Zou Yongjiu , Zhang Peng , Zhang Yuewen , Sun Peiting
Published: May 2024

To achieve the failure warning of marine systems and their equipment (MSAE), the threshold is one of the most prominent issues that should be solved first. In this study, a fusion model based on sparse Bayes and probabilistic statistical methods is applied to determine a new and more accurate adaptive alarm threshold. A multistep relevance vector machine (RVM) model is established to realize the parameter reconstruction in which the internal uncertainties caused by the degradation process and the external uncertainty caused by the loading, environment, and disturbances were considered. Then, a varying moving window (VMW) method is employed to determine the window size and achieve continuous data reconstruction. Further, the model based on Johnson distribution systems is utilized to complete the transformation of the residual parameters and calculate the adaptive threshold. Finally, the proposed adaptive decision threshold is successfully involved in the actual examples of the peak pressure and exhaust temperature of marine diesel engines. The results show that the proposed method can realize the continuous health condition monitoring of MSAE, successfully detect abnormal conditions in advance, achieve an early warning of failure, and reserve sufficient time for decision-making to prevent the occurrence of catastrophic disasters.