bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of dietary nonphytate phosphorus content on ileal lymphocyte subpopulations and cytokine expression in the cecal tonsils and spleen of laying hens that were or were not orally inoculated with Salmonella Typhimurium
Authors: Bai Shi P. , Huang Yong , Luo Yu H. , Wang Lei L. , Ding Xue M. , Wang Jian P. , Zeng Qiu F. , Zhang Ke Y.
Published: July 2015

OBJECTIVE To evaluate the effects of dietary nonphytate phosphorus (NPP) content on ileal lymphocyte subpopulations and cytokine expression in the cecal tonsils and spleen of hens that were or were not inoculated with Salmonella Typhimurium.

ANIMALS 64 Salmonella-free hens.

PROCEDURES Hens were fed a diet with 0.22% (control; n = 32) or 0.42% (high-P; 32) NPP for 6 weeks and then orally inoculated with S Typhimurium (5 × 107 CFUs) or PBSS. Tissues were obtained from 8 S Typhimurium–inoculated and 8 PBSS-inoculated hens from each group at 2 and 7 days postinoculation (DPI). Percentages of ileal CD4+ and CD8+ lymphocytes were determined by flow cytometry. Cytokine mRNA expression was determined by quantitative real-time PCR assays.

RESULTS For S Typhimurium–inoculated hens, plasma parathyroid hormone concentration was significantly increased and 1,25-dihydroxyvitamin D3 concentration was decreased in hens fed the high-P diet, compared with values in hens fed the control diet. Salmonella Typhimurium inoculation caused an increase in the percentage of ileal CD8+ lymphocytes and the expression of interleukin (IL)-1β, IL-6, IL-8, interferon-γ, IL-12, and IL-18 in the cecal tonsils and spleen and a decrease in the expression of IL-4 and IL-10 in the cecal tonsils. Hens fed the high-P diet had significantly increased splenic expression of interferon-γ at 2 DPI and IL-1β, IL-6, IL-12, and IL-18 at 7 DPI, compared with hens fed the control diet.

CONCLUSIONS AND CLINICAL RELEVANCE Results suggested there was a T-helper 1 cytokine reaction in the cecal tonsils and spleen of S Typhimurium–inoculated hens, and dietary NPP content altered calcium regulation hormone concentrations and affected splenic cytokine expression.
Personal Perspectives on Enablers and Barriers to Accessing Care for Hip and Knee Osteoarthritis
Authors: Ackerman Ilana N. , Livingston Jenni A. , Osborne Richard H.
Published: July 2015

Background

Despite increasing demand for joint replacement surgery and other health services for hip and knee osteoarthritis (OA), barriers and enablers to individual access to care are not well understood. A comprehensive understanding of drivers at all levels is needed to inform efforts for improving access.

Objective

The aim of this study was to explore perceived barriers and enablers to receiving conservative (nonsurgical) and surgical treatment for hip and knee OA.

Design

This was a qualitative study using directed content analysis.

Methods

Semistructured telephone interviews were conducted, with 33 participants randomly sampled from an Australian population-based survey of hip and knee OA. Each interview covered factors contributing to receiving treatment for OA and perceived barriers to accessing care. Interview transcripts were coded and organized into themes.

Results

Key barriers to accessing care for OA included medical opinions about saving surgery for later and the appropriate age for joint replacement. Other common barriers included difficulty obtaining referrals or appointments, long waiting times, work-related issues, and limited availability of primary and specialist care in some areas. Several participants perceived a lack of effective treatment for OA. Private health insurance was the most frequently cited enabler and was perceived to support the costs of surgical and conservative treatments, including physical therapy, while facilitating faster access to surgery. Close proximity to services and assistance from medical professionals in arranging care also were considered enablers.

Conclusions

People with hip or knee OA experience substantial challenges in accessing treatment, and these challenges relate predominantly to health professionals, health systems, and financial factors. Private health insurance was the strongest perceived enabler to accessing care for OA.
Reactive Balance in Individuals With Chronic Stroke: Biomechanical Factors Related to Perturbation-Induced Backward Falling
Authors: Salot Pooja , Patel Prakruti , Bhatt Tanvi
Published: July 2015

Background

An effective compensatory stepping response is the first line of defense for preventing a fall during sudden large external perturbations. The biomechanical factors that contribute to heightened fall risk in survivors of stroke, however, are not clearly understood. It is known that impending sensorimotor and balance deficits poststroke predispose these individuals to a risk of fall during sudden external perturbations.

Objective

The purpose of this study was to examine the mechanism of fall risk in survivors of chronic stroke when exposed to sudden, slip-like forward perturbations in stance.

Design

This was a cross-sectional study.

Methods

Fourteen individuals with stroke, 14 age-matched controls (AC group), and 14 young controls (YC group) were exposed to large-magnitude forward stance perturbations. Postural stability was computed as center of mass (COM) position (XCOM/BOS) and velocity (ẊCOM/BOS) relative to the base of support (BOS) at first step lift-off (LO) and touch-down (TD) and at second step TD. Limb support was quantified as vertical hip descent (Zhip) from baseline after perturbation onset.

Results

All participants showed a backward balance loss, with 71% of the stroke group experiencing a fall compared with no falls in the control groups (AC and YC groups). At first step LO, no between-group differences in XCOM/BOS and ẊCOM/BOS were noted. At first step TD, however, the stroke group had a significantly posterior XCOM/BOS and backward ẊCOM/BOS compared with the control groups. At second step TD, individuals with stroke were still more unstable (more posterior XCOM/BOS and backward ẊCOM/BOS) compared with the AC group. Individuals with stroke also showed greater peak Zhip compared with the control groups. Furthermore, the stroke group took a larger number of steps with shorter step length and delayed step initiation compared with the control groups.

Limitations

Although the study highlights the reactive balance deficits increasing fall risk in survivors of stroke compared with healthy adults, the study was restricted to individuals with chronic stroke only. It is likely that comparing compensatory stepping responses across different stages of recovery would enable clinicians to identify reactive balance deficits related to a specific stage of recovery.

Conclusions

These findings suggest the inability of the survivors of stroke to regain postural stability with one or more compensatory steps, unlike their healthy counterparts. Such a response may expose them to a greater fall risk resulting from inefficient compensatory stepping and reduced vertical limb support. Therapeutic interventions for fall prevention, therefore, should focus on improving both reactive stepping and limb support.
Using theCommon European Framework of Reference for Languagesto Teach Sign Language to Parents of Deaf Children
Authors: Snoddon Kristin
Published: July 2015

Abstract:

No formal Canadian curriculum presently exists for teaching American Sign Language (ASL) as a second language to parents of deaf and hard of hearing children. However, this group of ASL learners is in need of more comprehensive, research-based support, given the rapid expansion in Canada of universal neonatal hearing screening and the corresponding need for enhanced, early intervention service provision to families with deaf children. Inspired by parent sign language courses that have been developed in the Netherlands, the article outlines the rationale for and first steps toward developing a Canadian parent ASL curriculum framework that is aligned with the Common European Framework of Reference for Languages (CEFR). The CEFR and its proficiency levels hold much promise for innovation in second language teaching and learning, as they are based in conceptions of the language learner as a social agent who develops general and particular communicative competences while achieving everyday goals.
Parking Reservation for Managing Downtown Curbside Parking
Authors: Chen Zhibin , Yin Yafeng , He Fang , Lin Jane L.
Published: July 2015

This paper discusses a smartphone-based parking reservation system that manages a finite number of curbside parking spaces located at various places in a downtown area. Parking reservation schemes are designed to minimize the total social cost of parking, which is assumed to be a weighted sum of the cruising times for drivers to travel from their current locations to allocated parking spaces and the walking times from parking places to final destinations. With the assumption of perfect information on cruising and walking times, a simple reservation scheme to achieve an optimum allocation of parking spaces is presented. However, although the locations of drivers can be retrieved from their smart-phones, it is shown that drivers have an incentive to misreport their final destinations for their own benefit, which compromises the system benefit. Thus, the Vickrey–Clark–Groves mechanism is applied to determine the allocation of parking spaces and parking fees to minimize the total social cost while ensuring that all drivers report their final destinations truthfully. Last, a revenue redistribution scheme to reduce drivers' financial burden further and increase public acceptance of the reservation system is discussed.
Integrated Frequency Allocation and User Assignment in Multimodal Transit Networks
Authors: Verbas İ. Ömer , Mahmassani Hani S.
Published: July 2015

This paper presents an integrated solution method to the frequency-setting problem using optimization and assignment simulation. With a bilevel solution framework, an optimization problem is run at the upper level under the assumption that the total transit demand is fixed. The objective is to maximize wait time savings under the budget, fleet size, vehicle load, and policy headway constraints. At the lower level, an assignment and simulation algorithm is run; the algorithm models the demand response to the new frequency setting and transmits updated ridership and flow values to the upper level. The procedure is repeated until the improvement in the wait time savings converges. The platform is tested on the Chicago Transit Authority network in Illinois for the morning peak. The wait time savings in this experiment are converging and are found to be comparable with the results of a stand-alone frequency-setting algorithm that finds optimal solutions. Results are comparable with the optimal results of a stand-alone platform introduced in another study that modeled the demand response locally by using elasticities as opposed to networkwide modeling using assignment. The integrated platform can be used for medium-term strategic and long-term planning decisions.
Implications of Volatility in Day-to-Day Travel Flow and Road Capacity on Traffic Network Design Projects
Authors: Duell Melissa , Waller S. Travis
Published: July 2015

This work addresses the traffic network design problem when day-to-day uncertainties in travel demand and link capacity are taken into account. Specifically, this work proposes a network design formulation that uses a strategic behavior approach in which total demand and link capacity are treated as random variables, and a strategic user equilibrium results in fixed equilibrium link proportions. The bilevel model is formulated, system performance metrics are derived, and a solution method is then developed according to a tailored genetic algorithm. Results under varying levels of volatility reflect possible suboptimal project selection when a deterministic modeling approach is used.
Dynamic Assignment-Simulation Methodology for Multimodal Urban Transit Networks
Authors: Verbas İ. Ömer , Mahmassani Hani S. , Hyland Michael F.
Published: July 2015

This paper presents an integrated transit assignment-simulation tool. Finding least cost hyperpaths in a large-scale network and assigning travelers onto these paths are computationally challenging problems. Moreover, modeling the spatial and temporal complexities in a transit network that result from the discontinuities in transit events, such as missing a connection and not receiving a seat, exacerbates the issue of capturing realism. These challenges are overcome by ( a) using a least cost hyperpath algorithm that captures the multimodal, multipattern, time-, and approach-dependent features of a transit network to provide realistic optimal strategies; ( b) using a gap-based assignment approach to reach fast convergence; and ( c) developing a multiagent particle simulation platform that is able to capture the heterogeneities and the discontinuities in travel. The platform was tested on the Chicago Transit Authority network of 14,000 nodes and 64,000 links; 1.25 million travelers were assigned and simulated, along with 21,000 transit vehicles. The assignment-simulation framework can be used as a network evaluation tool to assist decision making at the strategic and operational levels.
Temporal lobe epilepsy in patients with nonlesional MRI and normal memory: an SEEG study
Authors: Suresh Suraj , Sweet Jennifer , Fastenau Philip S. , Lüders Hans , Landazuri Patrick , Miller Jonathan
Published: July 2015

OBJECT

Temporal lobe epilepsy (TLE) in the absence of MRI abnormalities and memory deficits is often presumed to have an extramesial or even extratemporal source. In this paper the authors report the results of a comprehensive stereoelectroencephalography (SEEG) analysis in patients with TLE with normal MRI images and memory scores.

METHODS

Eighteen patients with medically refractory epilepsy who also had unremarkable MR images and normal verbal and visual memory scores on neuropsychological testing were included in the study. All patients had seizure semiology and video electroencephalography (EEG) findings suggestive of TLE. A standardized SEEG investigation was performed for each patient with electrodes implanted into the mesial and lateral temporal lobe, temporal tip, posterior temporal neocortex, orbitomesiobasal frontal lobe, posterior cingulate gyrus, and insula. This information was used to plan subsequent surgical management.

RESULTS

Interictal SEEG abnormalities were observed in the mesial temporal structures in 17 patients (94%) and in the temporal tip in 6 (33%). Seizure onset was exclusively from mesial structures in 13 (72%), exclusively from lateral temporal cortex and/or temporal tip structures in 2 (11%), and independently from mesial and neocortical foci in 3 (17%). No seizure activity was observed arising from any extratemporal location. All patients underwent surgical intervention targeting the temporal lobe and tailored to the SEEG findings, and all experienced significant improvement in seizure frequency with a postoperative follow-up observation period of at least 1 year.

CONCLUSIONS

This study demonstrates 3 important findings: 1) normal memory does not preclude mesial temporal seizure onset; 2) onset of seizures exclusively from mesial temporal structures without early neocortical involvement is common, even in the absence of memory deficits; and 3) extratemporal seizure onset is rare when video EEG and semiology are consistent with focal TLE.
Cancer death rates in US congressional districts
Authors: Siegel Rebecca L. , Sahar Liora , Portier Kenneth M. , Ward Elizabeth M. , Jemal Ahmedin
Published: July 2015

Knowledge of the cancer burden is important for informing and advocating cancer prevention and control. Mortality data are readily available for states and counties, but not for congressional districts, from which representatives are elected and which may be more influential in compelling legislation and policy. The authors calculated average annual cancer death rates during 2002 to 2011 for each of the 435 congressional districts using mortality data from the National Center for Health Statistics and population estimates from the US Census Bureau. Age‐standardized death rates were mapped for all sites combined and separately for cancers of the lung and bronchus, colorectum, breast, and prostate by race/ethnicity and sex. Overall cancer death rates vary by almost 2‐fold and are generally lowest in Mountain states and highest in Appalachia and areas of the South. The distribution is similar for lung and colorectal cancers, with the lowest rates consistently noted in districts in Utah. However, for breast and prostate cancers, while the highest rates are again scattered throughout the South, the geographic pattern is less clear and the lowest rates are in Hawaii and southern Texas and Florida. Within‐state heterogeneity is limited, particularly for men, with the exceptions of Texas, Georgia, and Florida. Patterns also vary by race/ethnicity. For example, the highest prostate cancer death rates are in the West and north central United States among non‐Hispanic whites, but in the deep South among African Americans. Hispanics have the lowest rates except for colorectal cancer in Wyoming, eastern Colorado, and northern New Mexico. These data can facilitate cancer control and stimulate conversation about the relationship between cancer and policies that influence access to health care and the prevalence of behavioral and environmental risk factors. CA Cancer J Clin 2015;65:339–344. © 2015 American Cancer Society.
Direct and/or Indirect Roles for SUMO in Modulating Alpha-Synuclein Toxicity
Authors: Vijayakumaran Shamini , Wong Mathew , Antony Helma , Pountney Dean
Published: July 2015

α-Synuclein inclusion bodies are a pathological hallmark of several neurodegenerative diseases, including Parkinson’s disease, and contain aggregated α-synuclein and a variety of recruited factors, including protein chaperones, proteasome components, ubiquitin and the small ubiquitin-like modifier, SUMO-1. Cell culture and animal model studies suggest that misfolded, aggregated α-synuclein is actively translocated via the cytoskeletal system to a region of the cell where other factors that help to lessen the toxic effects can also be recruited. SUMO-1 covalently conjugates to various intracellular target proteins in a way analogous to ubiquitination to alter cellular distribution, function and metabolism and also plays an important role in a growing list of cellular pathways, including exosome secretion and apoptosis. Furthermore, SUMO-1 modified proteins have recently been linked to cell stress responses, such as oxidative stress response and heat shock response, with increased SUMOylation being neuroprotective in some cases. Several recent studies have linked SUMOylation to the ubiquitin-proteasome system, while other evidence implicates the lysosomal pathway. Other reports depict a direct mechanism whereby sumoylation reduced the aggregation tendency of α-synuclein, and reduced the toxicity. However, the precise role of SUMO-1 in neurodegeneration remains unclear. In this review, we explore the potential direct or indirect role(s) of SUMO-1 in the cellular response to misfolded α-synuclein in neurodegenerative disorders.
High Energy Radial Deposition of Diamond-Like Carbon Coatings
Authors: Suschke Konrad , Hübner René , Murmu Peter , Gupta Prasanth , Futter John , Markwitz Andreas
Published: July 2015

Diamond-like carbon (DLC) coatings were deposited with a new direct ion deposition system using a novel 360 degree ion source operating at acceleration voltage between 4 and 8 kV. Cross-sectional TEM images show that the coatings have a three layered structure which originates from changes in the deposition parameters taking into account ion source condition, ion current density, deposition angles, ion sputtering and ion source movement. Varying structural growth conditions can be achieved by tailoring the deposition parameters. The coatings show good promise for industrial use due to their high hardness, low friction and excellent adhesion to the surface of the samples.
Performance Testing of Suspension Plasma Sprayed Thermal Barrier Coatings Produced with Varied Suspension Parameters
Authors: Curry Nicholas , VanEvery Kent , Snyder Todd , Susnjar Johann , Bjorklund Stefan
Published: July 2015

Suspension plasma spraying has become an emerging technology for the production of thermal barrier coatings for the gas turbine industry. Presently, though commercial systems for coating production are available, coatings remain in the development stage. Suitable suspension parameters for coating production remain an outstanding question and the influence of suspension properties on the final coatings is not well known. For this study, a number of suspensions were produced with varied solid loadings, powder size distributions and solvents. Suspensions were sprayed onto superalloy substrates coated with high velocity air fuel (HVAF) -sprayed bond coats. Plasma spray parameters were selected to generate columnar structures based on previous experiments and were maintained at constant to discover the influence of the suspension behavior on coating microstructures. Testing of the produced thermal barrier coating (TBC) systems has included thermal cyclic fatigue testing and thermal conductivity analysis. Pore size distribution has been characterized by mercury infiltration porosimetry. Results show a strong influence of suspension viscosity and surface tension on the microstructure of the produced coatings.
Performance Comparison between Steam Injected Gas Turbine and Combined Cycle during Frequency Drops
Authors: Bahrami Saeed , Ghaffari Ali , Genrup Magnus , Thern Marcus
Published: July 2015

Single-shaft gas turbine and its cycles are sensitive to frequency drops and, therefore, sudden change loads or large frequency dips might affect their stability. This phenomenon is related to the reduction of the air mass flow passing through the machine during the frequency dips, which might lead to an interaction between governor and temperature control loop. In this paper, the performance of the combined cycle and steam-injected gas turbine are studied during frequency dips and transient maneuvers. For this purpose, two similar units are developed based on these cycles and their performances are studied in different scenarios. The simulation results show that the steam injected gas turbine has a better performance during frequency drops and it can handle relatively larger change loads.
Vehicular Internet: Security & Privacy Challenges and Opportunities
Authors: Zaidi Kamran , Rajarajan Muttukrishnan
Published: July 2015

The vehicular internet will drive the future of vehicular technology and intelligent transportation systems (ITS). Whether it is road safety, infotainment, or driver-less cars, the vehicular internet will lay the foundation for the future of road travel. Governments and companies are pursuing driver-less vehicles as they are considered to be more reliable than humans and, therefore, safer. The vehicles today are not just a means of transportation but are also equipped with a wide range of sensors that provide valuable data. If vehicles are enabled to share data that they collect with other vehicles or authorities for decision-making and safer driving, they thereby form a vehicular network. However, there is a lot at stake in vehicular networks if they are compromised. With the stakes so high, it is imperative that the vehicular networks are secured and made resilient to any attack or attempt that may have serious consequences. The vehicular internet can also be the target of a cyber attack, which can be devastating. In this paper, the opportunities that the vehicular internet offers are presented and then various security and privacy aspects are discussed and some solutions are presented.
Experience of Multisensory Environments in Public Space among People with Visual Impairment
Authors: Jenkins Gavin , Yuen Hon , Vogtle Laura
Published: July 2015

This qualitative study explored the role of sensory characteristics embedded in the built environment and whether they support or hinder people with visual impairment in their use of public spaces. An online survey link was e-mailed to the presidents and committee members of each state’s chapters and associations of the National Federation of the Blind in the United States, resulting in 451 direct invitations to participate. Written responses of the survey questions from 48 respondents with visual impairment were analyzed. Three main themes: Barriers, Supporters, and Context-Dependence emerged from the respondents’ experience of multisensory characteristics within the built environment. The four subthemes subsumed in Barriers were: (1) Population specific design, (2) Extreme sensory backgrounds, (3) Uneven ground surfaces and objects, and (4) Inconsistent lighting. For Supporters, respondents provided specific examples of various sensory characteristics in built environments, including audible cues and echoes, smells, tactile quality of the ground surface, and temperature. Context-Dependence referred to the effects of sensory characteristics embedded in public spaces depending on one’s vision condition, the proximity to the sensory cues and the purpose of the activities one was performing at that moment. Findings provide occupational therapy practitioners an in-depth understanding of the transactional relationship between embedded sensory characteristics in the built environment, occupations, and people with visual impairment in order to make appropriate modifications or removal of barriers that affect occupational performance and engagement. Suggestions for occupational therapists as well as architects, designers, planners, policy makers/legislators related to functional sensory cues in the design of built environments were provided to increase accessibility in the use of public spaces by people with visual impairment.
Human Leukocyte Antigen Class II Alleles Are Associated with Hepatitis C Virus Natural Susceptibility in the Chinese Population
Authors: Yue Ming , Xu Ke , Wu Meng-Ping , Han Ya-Ping , Huang Peng , Peng Zhi-Hang , Wang Jie , Su Jing , Yu Rong-Bin , Li Jun , Zhang Yun
Published: July 2015

Human leukocyte antigen (HLA) class II molecule influences host antigen presentation and anti-viral immune response. The aim of this study was to investigate whether single nucleotide polymorphisms (SNPs) within HLA class II gene were associated with different clinical outcomes of hepatitis C virus (HCV) infection. Three HLA class II SNPs (rs3077, rs2395309 and rs2856718) were genotyped by TaqMan assay among Chinese population, including 350 persistent HCV infection patients, 194 spontaneous viral clearance subjects and 973 HCV-uninfected control subjects. After logistic regression analysis, the results indicated that the rs2856718 TC genotype was significantly associated with the protective effect of the HCV natural susceptibility (adjusted OR: 0.712, 95% CI: 0.554–0.914) when compared with reference TT genotype, and this remained significant after false discovery rate (FDR) correction (p = 0.024). Moreover, the protective effect of rs2856718 was observed in dominant genetic models (adjusted OR: 0.726, 95% CI: 0.574–0.920), and this remained significant after FDR correction (p = 0.024). In stratified analysis, a significant decreased risk was found in rs2856718C allele in the male subgroup (adjusted OR: 0.778, 95% CI: 0.627–0.966) and hemodialysis subgroup (adjusted OR: 0.713, 95% CI: 0.552–0.921). Our results indicated that the genetic variations of rs2856718 within the HLA-DQ gene are associated with the natural susceptibility to HCV infection among the Chinese population.
Therapeutic Hypothermia in Spinal Cord Injury: The Status of Its Use and Open Questions
Authors: Wang Jiaqiong , Pearse Damien
Published: July 2015

Spinal cord injury (SCI) is a major health problem and is associated with a diversity of neurological symptoms. Pathophysiologically, dysfunction after SCI results from the culmination of tissue damage produced both by the primary insult and a range of secondary injury mechanisms. The application of hypothermia has been demonstrated to be neuroprotective after SCI in both experimental and human studies. The myriad of protective mechanisms of hypothermia include the slowing down of metabolism, decreasing free radical generation, inhibiting excitotoxicity and apoptosis, ameliorating inflammation, preserving the blood spinal cord barrier, inhibiting astrogliosis, promoting angiogenesis, as well as decreasing axonal damage and encouraging neurogenesis. Hypothermia has also been combined with other interventions, such as antioxidants, anesthetics, alkalinization and cell transplantation for additional benefit. Although a large body of work has reported on the effectiveness of hypothermia as a neuroprotective approach after SCI and its application has been translated to the clinic, a number of questions still remain regarding its use, including the identification of hypothermia’s therapeutic window, optimal duration and the most appropriate rewarming rate. In addition, it is necessary to investigate the neuroprotective effect of combining therapeutic hypothermia with other treatment strategies for putative synergies, particularly those involving neurorepair.
Murine K2P5.1 Deficiency Has No Impact on Autoimmune Neuroinflammation due to Compensatory K2P3.1- and KV1.3-Dependent Mechanisms
Authors: Bittner Stefan , Bobak Nicole , Hofmann Majella-Sophie , Schuhmann Michael , Ruck Tobias , Göbel Kerstin , Brück Wolfgang , Wiendl Heinz , Meuth Sven
Published: July 2015

Lymphocytes express potassium channels that regulate physiological cell functions, such as activation, proliferation and migration. Expression levels of K2P5.1 (TASK2; KCNK5) channels belonging to the family of two-pore domain potassium channels have previously been correlated to the activity of autoreactive T lymphocytes in patients with multiple sclerosis and rheumatoid arthritis. In humans, K2P5.1 channels are upregulated upon T cell stimulation and influence T cell effector functions. However, a further clinical translation of targeting K2P5.1 is currently hampered by a lack of highly selective inhibitors, making it necessary to evaluate the impact of KCNK5 in established preclinical animal disease models. We here demonstrate that K2P5.1 knockout (K2P5.1−/−) mice display no significant alterations concerning T cell cytokine production, proliferation rates, surface marker molecules or signaling pathways. In an experimental model of autoimmune neuroinflammation, K2P5.1−/− mice show a comparable disease course to wild-type animals and no major changes in the peripheral immune system or CNS compartment. A compensatory upregulation of the potassium channels K2P3.1 and KV1.3 seems to counterbalance the deletion of K2P5.1. As an alternative model mimicking autoimmune neuroinflammation, experimental autoimmune encephalomyelitis in the common marmoset has been proposed, especially for testing the efficacy of new potential drugs. Initial experiments show that K2P5.1 is functionally expressed on marmoset T lymphocytes, opening up the possibility for assessing future K2P5.1-targeting drugs.
Autonomic Dysregulation in Multiple Sclerosis
Authors: Pintér Alexandra , Cseh Domonkos , Sárközi Adrienn , Illigens Ben , Siepmann Timo
Published: July 2015

Multiple sclerosis (MS) is a chronic, progressive central neurological disease characterized by inflammation and demyelination. In patients with MS, dysregulation of the autonomic nervous system may present with various clinical symptoms including sweating abnormalities, urinary dysfunction, orthostatic dysregulation, gastrointestinal symptoms, and sexual dysfunction. These autonomic disturbances reduce the quality of life of affected patients and constitute a clinical challenge to the physician due to variability of clinical presentation and inconsistent data on diagnosis and treatment. Early diagnosis and initiation of individualized interdisciplinary and multimodal strategies is beneficial in the management of autonomic dysfunction in MS. This review summarizes the current literature on the most prevalent aspects of autonomic dysfunction in MS and provides reference to underlying pathophysiological mechanisms as well as means of diagnosis and treatment.
Phylogenetic Diversity of Diazotrophs along an Experimental Nutrient Gradient in Mangrove Sediments
Authors: Romero Isabel , Jacobson-Meyers Myrna , Fuhrman Jed , Capone Douglas
Published: July 2015

The diversity of diazotrophs was studied in the sediment of mangrove forests (Twin Cays, Belize) subjected to a long-term fertilization with nitrogen and phosphorus. Terminal Restriction Fragment Length Polymorphism (TRFLP) and cloning of PCR-amplified nifH genes were combined via in silico analysis to assign clones to TRFLP-nifH phylotypes, as well as to characterize the occurrence of phylotypes in response to environmental conditions. Results indicated that mangrove sediments from Belize harbor a unique diazotrophic community with a low metabolic diversity dominated by sulfate reducers. The variability of potential nitrogen-fixing sulfate reducers was explained by several environmental parameters, primarily by the abundance of dead roots in the sediments, and the concentration of H2S in the pore-waters. This study describes the complexity of microbial communities within the mangrove sediments with specific functional groups varying along environmental gradients.
Hydrodynamic and Sediment Modelling within a Macro Tidal Estuary: Port Curtis Estuary, Australia
Authors: Dunn Ryan , Zigic Sasha , Burling Murray , Lin Hsin-Hui
Published: July 2015

An understanding of sediment transport processes and resultant concentration dynamics in estuaries is of great importance to engineering design awareness and the management of these environments. Predictive modelling approaches provide an opportunity to investigate and address potential system responses to nominated events, changes, or conditions of interest, often on high temporal and spatial resolution scales. In this study, a three-dimensional hydrodynamic model and wave model were validated and applied to generate forcing conditions for input into a sediment transport model for the period 7 May 2010–30 October 2010 within a macro tidal estuary, Port Curtis estuary (Australia). The hydrodynamic model was verified against surface and near-bottom current measurements. The model accurately reproduced the variations of surface and near-bottom currents at both a mid-estuary and upper-estuary location. Sediment transport model predictions were performed under varying meteorological conditions and tidal forcing over a 180-day period and were validated against turbidity data collected at six stations within Port Curtis estuary. The sediment transport model was able to predict both the magnitudes of the turbidity levels and the modulation induced by the neap and spring tides and wind-wave variations. The model-predicted (converted) turbidity levels compared favourably with the measured surface water turbidity levels at all six stations. The study results have useful practical application for Port Curtis estuary, including providing predictive capabilities to support the selection of locations for monitoring/compliance sites.
Friction Reduction and Reliability for Engines Bearings
Authors: Ligier Jean-Louis , Noel Bruno
Published: July 2015

Friction reduction is necessary in order to decrease engine emissions, so bearing friction needs to be reduced but with the constraint that low friction solutions should not affect bearing reliability. To meet this target of low friction and high reliability bearings, several technical solutions are reviewed. Particular attention is paid to evaluating friction reduction performance for each solution. Damage risks relating to customer uses are also presented in order to check that these risks are negligible with low friction solutions.
A Columbia River Basalt Group Aquifer in Sustained Drought: Insight from Geophysical Methods
Authors: Piersol Mark , Sprenke Kenneth
Published: July 2015

Aquifers within the Columbia River Basalt Group (CRBG) provide a critical water supply throughout much of the Pacific Northwest of the United States. Increased pumping has resulted in water level declines in this region. Recharge into this aquifer system is generally not well understood. Recent suggestions of probable decades-long droughts in the 21st century add to this problem. We show that geophysical methods can provide useful parameters for improved modeling of aquifers in a primary CRBG aquifer located on the eastern edge of the Columbia Plateau. Groundwater models depend in part on the area, thickness, porosity, storativity, and nature of confinement of this aquifer, most of which are poorly constrained by existing well information and previous stress tests. We have made use of surface gravity measurements, borehole gravity measurements, barometric efficiency estimates, earth tidal response, and earthquake seismology observations to constrain these parameters. We show that the aquifer, despite its persistent drawdown, receives a great deal of recharge annually. Much of the recharge to the aquifer is due to leakage from overlying flows, ultimately tied to precipitation, an important result for future aquifer management in times of sustained drought.
Fusion of Visible and Thermal Descriptors Using Genetic Algorithms for Face Recognition Systems
Authors: Hermosilla Gabriel , Gallardo Francisco , Farias Gonzalo , Martin Cesar
Published: July 2015

The aim of this article is to present a new face recognition system based on the fusion of visible and thermal features obtained from the most current local matching descriptors by maximizing face recognition rates through the use of genetic algorithms. The article considers a comparison of the performance of the proposed fusion methodology against five current face recognition methods and classic fusion techniques used commonly in the literature. These were selected by considering their performance in face recognition. The five local matching methods and the proposed fusion methodology are evaluated using the standard visible/thermal database, the Equinox database, along with a new database, the PUCV-VTF, designed for visible-thermal studies in face recognition and described for the first time in this work. The latter is created considering visible and thermal image sensors with different real-world conditions, such as variations in illumination, facial expression, pose, occlusion, etc. The main conclusions of this article are that two variants of the proposed fusion methodology surpass current face recognition methods and the classic fusion techniques reported in the literature, attaining recognition rates of over 97% and 99% for the Equinox and PUCV-VTF databases, respectively. The fusion methodology is very robust to illumination and expression changes, as it combines thermal and visible information efficiently by using genetic algorithms, thus allowing it to choose optimal face areas where one spectrum is more representative than the other.
Energy-Efficient Channel Handoff for Sensor Network-Assisted Cognitive Radio Network
Authors: Usman Muhammad , Khan Muhammad , Vu-Van Hiep , Insoo Koo
Published: July 2015

The visiting and less-privileged status of the secondary users (SUs) in a cognitive radio network obligates them to release the occupied channel instantly when it is reclaimed by the primary user. The SU has a choice to make: either wait for the channel to become free, thus conserving energy at the expense of delayed transmission and delivery, or find and switch to a vacant channel, thereby avoiding delay in transmission at the expense of increased energy consumption. An energy-efficient decision that considers the tradeoff between energy consumption and continuous transmission needs to be taken as to whether to switch the channels. In this work, we consider a sensor network-assisted cognitive radio network and propose a backup channel, which is sensed by the SU in parallel with the operating channel that is being sensed by the sensor nodes. Imperfect channel sensing and residual energy of the SU are considered in order to develop an energy-efficient handoff strategy using the partially observable Markov decision process (POMDP), which considers beliefs about the operating and backup channels and the remaining energy of the SU in order to take an optimal channel handoff decision on the question “Should we switch the channel?” The objective is to dynamically decide in each time slot whether the SU should switch the channel or not in order to maximize throughput by utilizing energy efficiently. Extensive simulations were performed to show the effectiveness of the proposed channel handoff strategy, which was demonstrated in the form of throughput with respect to various parameters, i.e., detection probability, the channel idle probabilities of the operating and backup channels, and the maximum energy of the SU.
Dynamic Reconfiguration of a RGBD Sensor Based on QoS and QoC Requirements in Distributed Systems
Authors: Munera Eduardo , Poza-Lujan Jose-Luis , Posadas-Yagüe Juan-Luis , Simó-Ten José-Enrique , Noguera Juan
Published: July 2015

The inclusion of embedded sensors into a networked system provides useful information for many applications. A Distributed Control System (DCS) is one of the clearest examples where processing and communications are constrained by the client’s requirements and the capacity of the system. An embedded sensor with advanced processing and communications capabilities supplies high level information, abstracting from the data acquisition process and objects recognition mechanisms. The implementation of an embedded sensor/actuator as a Smart Resource permits clients to access sensor information through distributed network services. Smart resources can offer sensor services as well as computing, communications and peripheral access by implementing a self-aware based adaptation mechanism which adapts the execution profile to the context. On the other hand, information integrity must be ensured when computing processes are dynamically adapted. Therefore, the processing must be adapted to perform tasks in a certain lapse of time but always ensuring a minimum process quality. In the same way, communications must try to reduce the data traffic without excluding relevant information. The main objective of the paper is to present a dynamic configuration mechanism to adapt the sensor processing and communication to the client’s requirements in the DCS. This paper describes an implementation of a smart resource based on a Red, Green, Blue, and Depth (RGBD) sensor in order to test the dynamic configuration mechanism presented.
On the Accuracy Potential in Underwater/Multimedia Photogrammetry
Authors: Maas Hans-Gerd
Published: July 2015

Underwater applications of photogrammetric measurement techniques usually need to deal with multimedia photogrammetry aspects, which are characterized by the necessity of handling optical rays that are refracted at interfaces between optical media with different refractive indices according to Snell’s Law. This so-called multimedia geometry has to be incorporated into geometric models in order to achieve correct measurement results. The paper shows a flexible yet strict geometric model for the handling of refraction effects on the optical path, which can be implemented as a module into photogrammetric standard tools such as spatial resection, spatial intersection, bundle adjustment or epipolar line computation. The module is especially well suited for applications, where an object in water is observed by cameras in air through one or more planar glass interfaces, as it allows for some simplifications here. In the second part of the paper, several aspects, which are relevant for an assessment of the accuracy potential in underwater/multimedia photogrammetry, are discussed. These aspects include network geometry and interface planarity issues as well as effects caused by refractive index variations and dispersion and diffusion under water. All these factors contribute to a rather significant degradation of the geometric accuracy potential in underwater/multimedia photogrammetry. In practical experiments, a degradation of the quality of results by a factor two could be determined under relatively favorable conditions.
Performance Based Evaluation of Concrete Strength under Various Curing Conditions to Investigate Climate Change Effects
Authors: Kim Tae-Kyun , Choi Seung-Jai , Kim Jang-Ho , Kim Byung-Yun
Published: July 2015

Recently, the manifestation of global warming-induced climate change has been observed through super typhoons, heavy snowfalls, torrential rains, and extended heat waves. These climate changes have been occurring all over the world and natural disasters have caused severe damage and deterioration of concrete structures and infrastructure. In an effort to deal with these problems due to extreme and abnormal climate changes, studies have been conducted to develop construction technologies and design guidelines. Nevertheless, study results applicable to construction sites continue to be ineffective and insufficient. Therefore, this study proposes ways to cope with climate change by considering the effect of concrete curing condition variations on concrete material performance. More specifically, the 3-, 7- and 28-day compressive and split tensile strength properties of concrete mix cured under various climatic factors including temperature, relative humidity, wind speed, and sunlight exposure time were evaluated to determine whether the concrete meets the current design requirements. Thereafter, a performance based evaluation (PBE) was performed using satisfaction probabilities based on the test values to understand the problems associated with the current mix proportion design practice and to identify countermeasures to deal with climate change-induced curing conditions.
Enhancing Trifocal Leadership Practices Using Simulation in a Pediatric Charge Nurse Orientation Program
Authors: Clark Teresa J. , Yoder-Wise Patricia S.
Published: July 2015

A well-established charge nurse orientation program was enhanced with the addition of a simulation, addressing three primary populations (the trifocus) with whom charge nurses interact: patients, patients’ parents, and other staff members. In this pilot quality improvement project, 20 staff nurses enrolled in the orientation program and were assigned a mentor. Only one participant used the mentorship opportunity; therefore, it is not discussed here. Twelve nurses completed all charge nurse classes and a simulation scenario of caring for a deteriorating infant. The nurses were given an opportunity to reflect on leadership practices after the simulation. Thematic analysis from qualitative, reflective data supported the enhanced understanding of managing complex patients, a code situation, and teams; guiding a team’s novice nurse; leading as a charge nurse; and using clinical and critical thinking skills. All nurses reported that the simulation as experiential learning helped them to meet their leadership goals.

J Contin Educ Nurs.
2015;46(7):311–317.
Challenging Psychiatric Discrimination in Insurance
Authors: Carroll Bernard J.
Published: July 2015

The Mental Health Parity and Addiction Equity Act of 2008 did not include commercial disability insurance and life insurance contracts. Strategies to challenge these discriminatory policies are not widely understood because of confidential, out-of-court settlements. This article elaborates on strategies to challenge such discriminatory insurance contracts by describing the approaches used in a successful challenge on behalf of a patient initially diagnosed with a depressive disorder.

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Psychiatr Ann
. 2015;45(7):372–376.]