bluuebunny/crossref_metadata_2025 huggingface dataset:
Cortex Mori extract inhibits migration and invasion of lung adenocarcinoma cells by blocking RECQL4-induced NF-κB and ERK signaling pathways
Authors: Qin Li  , Wei Enyao , Wenbin Zhang  , Feng Zhang
Published: July 2023

Lung adenocarcinoma (LUAC) is one of the usual tumors of the lung with high mortality rate. RecQ-like helicase 4 (RECQL4) gene has been discovered to take part in the progression of different cancers by undertaking as an oncogene, and is relevant with poor prognosis of LUAC. Cortex Mori (CM) extract has been investigated to affect cellular progress to regulate different diseases. However, the detailed functioning of RECQL4 and CM extract, as well as their regulatory mechanisms in LUAC, has not been illustrated. The purpose of the present study was to probe the impact of RECQL4 and CM extract on progression of LUAC. The expression of RECQL4 in LUAC was assessed by The Cancer Genome Atlas (TCGA) database. The mRNA expression of RECQL4 was examined by real-time quantitative polymerase chain reaction. The protein expressions (epithelial–mesenchymal transition [EMT] process, nuclear factor kappa B [NF-κB] and extracellular signal-regulated kinase [ERK] signaling pathways-related proteins) were determined by Western blot analysis. The cell proliferation was tested through cell counting kit-8 assay. Cell migration and invasion was affirmed by wound-healing and transwell assays. The cell senescence was assessed through senescence-associated beta-galactosidase staining. The cell cycle was inspected by flow cytometry. Our findings demonstrated that RECQL4 exhibited higher expression in LUAC tissues and cell lines. Through functional experiments, we found that RECQL4 facilitated cell proliferation, migration, and invasion as well as EMT progression. In addition, RECQL4 relieved cell cycle arrest and cell senescence. Moreover, RECQL4 activated NF-κB and ERK signaling pathways by enhancing phospho(p)-p65–p65 and p-ERK–ERK levels in LUAC. CM extract exhibited antitumor effects in LUAC, and blocked RECQL4-induced NF-κB and ERK signaling pathways. Our results manifested that CM extract inhibited migration and invasion of LUAC cells by blocking RECQL4-induced NF-κB and ERK signaling pathways. This result could provide a promising therapeutic strategy for LUAC.
His Majesty the Source
Authors: Soboleva Larisa
Published: July 2023

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The Kuranty in Context: Dutch Lading Lists and Their Russian Translations. Part 1
Authors: Waugh Daniel Clarke
Published: July 2023

There is a great deal of recent scholarship exploring how foreign news reached early modern Russia and what its impact there was. Of particular importance is the study of the kuranty, the translations of Western newspapers and pamphlets. By examining closely what may seem to have been an unusual choice to translate from Dutch newspapers – the cargo lists of Dutch ships from the East Indies – this article suggests how it might be possible to contextualize the news translations more broadly than has been done to date. It is important to examine the significance of the news where it originally appeared, since its significance in the Russian context may be quite different. And it is also important not just to focus on the Russian government’s interest in the political news that informed its foreign policy. Over a period of decades, the importance given certain topics may have changed. The interests of the translators themselves – among them Andrei Vinius – may help to explain why they selected particular items for translation from the substantial quantity of foreign news which began to arrive in Moscow regularly upon the establishment of the foreign postal connection in 1665. The article is published in two parts, the first one here covering the background and the analysis of the evidence up through 1665. The second part, to appear in a subsequent number of the journal, will deal with the lading lists of 1667 and 1671 and the complex analysis of the context within which they may have been of particular interest in Moscow.
Moscow as Perceived by Alexander II’s Elder Sons
Authors: Melentev Fedor
Published: July 2023

This article examines the attitude to Moscow of Grand Princes Nicholas Alexandrovich and Alexander Alexandrovich; the latter became Emperor Alexander III afterwards. The opinion has taken root in historiography and become self-evident that the peacemaker tsar loved the ancient capital like no other ruler of the Russian Empire. The article aims to reconstruct the attitude of Alexander III and his elder brother to Moscow and understand why it arose and how it changed over time. The research methodology considers the achievements of the new political history, the history of everyday life, and the history of emotions. The article refers to unpublished letters, diaries, and memoirs of contemporaries, the grand princes’ diaries, and their correspondence with Alexander II, Empress Maria Alexandrovna, Grand Princes Mikhail Nikolaevich, and Vladimir Alexandrovich, which have not been introduced into scholarly circulation previously. The analysis makes it possible to assert that warm feelings for Mother See did not arise in the tsar-liberator’s eldest sons immediately. The formation of their attitude toward the ancient capital was influenced by professors of Moscow University invited to teach the Grand Princes, such as statistician I. K. Babst, lawyer K. P. Pobedonostsev, and historian S. M. Solovyov. Also, the princes were influenced by the conservative Moscow periodicals they read and Empress Maria Alexandrovna. Unlike the Tsarina, Alexander II was suspicious of the Moscow public, which seemed insufficiently loyal to him. Therefore, his sons’ positive attitude towards Moscow and its society was not something taken for granted. At the same time, attempts to influence the sympathies of the grand princes to the ancient capital pursued the goal not so much to stimulate the tsarevichs’ interest in Moscow antiquities as to make them supporters of “people’s autocracy”, as well as adherents of the “national policy”. In conclusion, the author analyzes the phrase attributed to Alexander III that “Moscow is the temple of Russia, and the Kremlin is its altar” providing arguments about the doubtfulness of its authorship.
Conflict Landscapes of the Great War: The Spatial and Ecological Dimension of Military History
Authors: Nagornaia Oksana , Lingen Kerstin von
Published: July 2023

The spatial and environmental dimension of WWI has recently taken the central place in academic debates on the military history of the “short twentieth century”. At present, the large-scale conflict of humanity and nature under totalized warfare is recognized as no less significant to the existential experience of combatants and civilians than actual battles. Functioning as a demiurge, the Great War created and re-molded landscapes, accelerated development trends shaped during the industrial era, triggered the construction and demolition of infrastructure, and determined the resource policy, economic practices, and language constructs of national communities during subsequent historical periods. Textual and visual narratives of the war feature the following three dimensions of the environment: a subject and adversary (sometimes even more dangerous than the real enemy); an object of destruction, invasion, and ordering; and an anthropological construct defining behavioral strategies and the memorial culture relating to the conflict. Modern researchers share a unanimous opinion that the pivotal role of the clash between humanity and the environment during WWI for subsequent historical development is paradoxically at odds with the degree to which the clash has been studied. This may be linked with the fact that the multidimensionality of militarized landscapes would require a research methodology incorporating elements of military history, ecology, anthropology, archaeology, geology (landscape studies), and cultural geography. Such a creative symbiosis has become possible only recently, owing to the adoption of the interdisciplinary approach by military historians. The gradual uptake of innovative study techniques has resulted in the uneven development of the spatial and environmental history of the First World War as a research field: at present, the best-studied locations are confined to the western front and, partly, the colonial periphery. This publication presents a review of the recent conceptual publications by authors developing this research avenue and seeks to identify the heuristic potential of the concepts “Anthropocene”, “belligerent landscapes”, “landscape biographies”, and “layered landscapes”, including their applicability to the history of the Eastern Front of the First World War.
Oil Fires of the First World War: Military Use and Destruction of Galicia’s Fuel Industry
Authors: Golubinov Iaroslav
Published: July 2023

During the First World War, the Russian army was faced with the task of developing areas captured from the adversary and sought to integrate the new territorial acquisitions into the Russian economy while simultaneously adapting them for effective warfare. At the time of its occupation by the Russian troops, Austrian Galicia already existed as a fully-formed industrial landscape dominated by private and state-controlled oil fields and refineries. The environmental situation in Galicia had remained extremely problematic over several decades preceding the First World War due to intensive oil extraction and manufacturing of petroleum products. The Russian administration which largely ignored the environmental issues (or, rather, exacerbated them) attempted to resume oil mining in Galicia and organize the production and distribution of petrol, kerosene, and fuel oil to supply the urban centers as well as the army and railways. However, the 1915 Gorlice – Tarnów offensive by the German army prevented Russia from taking full advantage of the Galician oil production capacities and prompted the Russian commandment to apply the scorched earth tactic. Special military units were ordered to destroy most drilling rigs, oil reservoirs, and refineries around Boryslav and Drohobych. Official reports and testimonies by eyewitnesses provide a striking picture of demolition on a vast territory to the west and southwest of Lviv. The documentary and historiographical sources lack consensus as to the actual number of facilities destroyed and the overall damage caused to the country’s economy during the retreat of the Russian troops in April–May 1915. This study aims, firstly, to identify the key features of these events, and secondly, to explore the development of the Galician combat landscape, whose elements morph into “combat formations”, equally fit for productive activity and total (self-)destruction during warfare.
Anton Vladimirovich Kartashev as a Prophet not in His Own Country
Authors: Antoshchenko Aleksandr
Published: July 2023

This article discusses the justification by Anton Kartashev, a Russian emigrant historian, theologian, and public figure for the ideal of Holy Rus’, which was supposed to serve as a religious basis for the creation of the cultural and historical identity of the representatives of the “second wave” of emigration from the Soviet Union during the Second World War. In the case study, the author of the article applies methods of “personal history” and “new intellectual history” to both historical works and such ego documents as letters published and stored in the Bakhmeteff Archive of Russian and East European Culture at Columbia University. Considering the genesis of the concept of Holy Rus’ in the publications of Karashev before the war, the author of the article shows the influence on the content of the political views of the public man who followed the principles of centrism, intransigence, and non-precondition. Along with this, the article reveals the links between the historical and cultural, canonical and dogmatic justifications of the ideal in his narratives which were constructed as the Hegelian triad: thesis – antithesis – synthesis. Kartashev represented the process of transformation of the emerging symphony of church and state in Ancient Rus’ and Muscovite State through its denial in the laic culture of the Russian Empire after the Petrine reforms into a new desired symphony of church and society. The central place in the article is occupied by the characteristics of changes among Russian émigrés at the end and after the Second World War and by the explanation of the impact of these changes on the motivation of Kartashev to present his vision of the ideal of Holy Rus’ in a form of a book. As a result of studying the long process of preparing the edition and the subsequent reviewing and discussion of the book, it is shown that this ideal was perceived ambiguously. Such perception of Kartashev’s book was influenced by the complication of ideological divisions among Russian emigrants as a result of the spread among the part of them of the mood of “Soviet patriotism” and the addition to their ranks of anti-Soviet-minded “displaced persons” from the Soviet Union, as well as differences in the vision of life prospects by the representatives of the “older” generations of refugees who had to leave Soviet Russia soon after the revolution and the “younger” one, who were entering into life abroad. As a result, most of the participants in the discussion of the book, speaking kindly about the author, nevertheless emphasized their disagreement with both the political and religious-dogmatic justifications of the ideal of Holy Rus’ as a basis for their cultural and historical identity.
Towards a Conceptual-Historical Critique of the Essentialist and Teleological Interpretations of Russian History. Part 1
Authors: Ingerflom Claudio
Published: July 2023

The author discusses some of the dominant assertions in the literature on Russian history. One of them is the disqualification of the myth of the benevolent tsar as “false”. This disqualification is accompanied by the formulas “naïve or popular monarchism”, which designate the “pre-scientific illusions” that would have guided the collective movements of resistance to autocracy. Given the importance of collective representations of the tsar and power in Russian history, the theoretical premises on which the above-mentioned disqualifications are based affect the general interpretation of this history, for example the conception of the Russian people as “passive”. The author proposes to abandon this positivist scaffolding and approach the sources from other theoretical perspectives, in particular conceptual history (Begriffsgeschichte), to pose a radically different question: what truth is contained in the myth of the benevolent tsar and to reconstruct, against the essentialist and teleological vision, the historicity of the collective resistance to power in Russia. The first part studies the genealogy of the expression samozvan/ets/stvo (self-appointment), its original meaning – individual initiative against divine appointment – and its functions in the autocratic political paradigm. The lack of heuristic value of the formulas of “popular, or naïve monarchism,” the logic of which is to deprive the most oppressed segments of the population of their culture and language, is emphasized.
The Belgorod Line as an Object of Research: Heuristic and Analytical Possibilities of Traditional and Modern Historical Methods
Authors: Lyapin Denis
Published: July 2023

Published in 2020, The Belgorod Line. History. Fortification. People, a book by Andrey Papkov, Nikolay Petrukhintsev, and Dmitry Khitrov is the first attempt to understand and update modern achievements in studying the Belgorod Line. The authors reveal the historical specifics behind the construction of this military-defensive line in the broad historical context of the seventeenth century. They show the background of events (before 1635), the building process, and the social processes after the line was erected (1658). A special place is given to the military reforms of Tsar Alexei Mikhailovich, preceding the famous army reforms of Peter the Great. The Belgorod Line. History. Fortification. People allows the scholarly community to move to a new stage in understanding the features of the social and military history of the southern border of Russia, but first, it is important to understand the political context of the events of the construction of the Belgorod line. Until 1645, the construction of fortifications was not systematic. But after the accession to the throne of Alexei Mikhailovich Romanov, the construction of the Belgorod line acquired a clear logic. However, in 1654 Russia entered the war with Poland, and the military potential of the southern Russian border was used for other military tasks in the west. This political context of the development of events is reflected in the book under review.
Efeitos da terapia vocal indireta via telefonoaudiologia na autoavaliação e qualidade vocal de profissionais da educação física
Authors: Lima Catarina , Diedio Pollyana , Brasolotto Alcione Ghedini , Antonetti-Carvalho Angélica Emygdio , Silverio Kelly
Published: July 2023

RESUMO Objetivo: este estudo objetivou verificar os efeitos da terapia vocal indireta (TVI), aplicada via telefonoaudiologia, em profissionais da educação física na autoavaliação e qualidade vocal. Métodos: 16 profissionais da Educação Física, com idades entre 18 e 50 anos, de ambos os sexos, participaram do estudo. Foram submetidos a oito sessões de TVI, duas vezes/semana, 30 minutos cada. As sessões e avaliações foram ministradas à distância. Foram trabalhados conhecimento sobre saúde vocal, para modificar hábitos vocais e de saúde geral, estratégias de enfrentamento, gerenciamento de estresse e interação terapêutica. Aplicaram-se protocolos: Índice de Triagem de Distúrbios Vocais, Escala de Sintomas Vocais (ESV), Índice de Desvantagem Vocal (IDV) e gravação vocal (/a/ e contagem), avaliando-se o grau geral da qualidade vocal, pré e pós TVI. Utilizou-se o Teste de Wilcoxon (p<0,05) nas comparações. Resultados: houve diminuição significante nos valores dos protocolos ESV (total p=0,041; limitação p=0,032), IDV (total p=0,012 e orgânico p=0,005), e no grau geral da qualidade vocal na vogal (p=0,011). Conclusão: a TVI aplicada por meio da telefonoaudiologia, em profissionais da Educação Física, tem efeitos positivos nos sintomas vocais/laringofaríngeos, melhorando a autopercepção da desvantagem vocal. A TVI melhorou significantemente o grau geral da qualidade vocal, apenas na emissão da vogal sustentada.
Influência do ambiente familiar, percepção parental e nível econômico no vocabulário receptivo de crianças
Authors: Souza Débora Ocarlina de , Santos Lívia Pereira dos , Martins-Reis Vanessa de Oliveira , Martins Ana Luiza de Freitas , Morais Rosane Luzia de Souza , Santos Juliana Nunes
Published: July 2023

RESUMO Objetivo: verificar a influência do ambiente familiar, percepção parental e condições socioeconômicas no vocabulário receptivo de escolares do ensino fundamental. Métodos: trata-se de estudo observacional transversal analítico. Os escolares, selecionados por amostragem proporcional estratificada, realizaram o Teste de Vocabulário Receptivo. Os responsáveis responderam à anamnese e ao Inventário de Recursos do Ambiente Familiar. Inicialmente, realizou-se análise bivariada pelo teste Qui-quadrado, considerando p<0,20. Na análise multivariada de regressão logística binária, considerou-se o valor p<0,05 e a qualidade do modelo foi avaliada pelo método Hosmer-Lemeshow. Resultados: dos 263 escolares, 131 são do sexo masculino, 142 do terceiro ano, possuem idade média de 7,6 anos (±0,57) e 111 apresentam vocabulário receptivo rebaixado. Na análise bivariada, observou-se relação entre percepção parental acerca do aprendizado da leitura, da escrita, repetência escolar e o desfecho (p<0,05). Também foram para análise multivariada as variáveis recursos do ambiente e estabilidade da vida familiar (p<0,20). Conclusão: a percepção parental de dificuldade de leitura e de escrita e a falta de estabilidade familiar foram fatores associados ao pior vocabulário receptivo.
Correntes do Conhecimento: o bailado do Santo Daime como dança decolonial
Authors: Flecha Ana
Published: July 2023

Resumo: Santo Daime, religião ayahuasca da Amazônia brasileira fundada em 1930, tem como uma de suas principais práticas uma dança chamada bailado que gera correntes energéticas por meio do balanço coletivo. Os praticantes assumem papéis de espectadores e performer ao dançarem o bailado e se envolvem em um discurso transcorpóreo com vários seres. Com base nos hinos do Santo Daime, na observação participante e em registros pessoais como daimista, neste artigo argumenta-se que o bailado decoloniza a dança de três maneiras: como parte de um sistema de conhecimento caboclo único; através do cultivo de subjetividades coletivas pelos participantes; e ao desafiar as definições eurocêntricas de dança.
Diante da Performance: contribuições do pragmatismo especulativo para a sociologia da arte
Authors: Martins Daniela Felix
Published: July 2023

Resumo: O texto pretende analisar os principais aspectos que constituem a experiência performática, bem como analisar as contribuições do pragmatismo-especulativo para renovação do campo da sociologia da arte. O texto estrutura-se em três partes: 1) contextualização do trabalho no âmbito do projeto de pesquisa Protocolos de musealização de ações performáticas em museus públicos de arte e a sua problemática desde o ponto de vista sociológico; 2) definição do conceito de experiência; 3) verificação do rendimento analítico desse conceito para a pesquisa em arte performática. Como conclusão central, o texto buscou sistematizar as maneiras pelas quais a sociologia pragmática-especulativa pode fornecer acesso às complexas redes de atores e práticas sociais envolvidas na produção artística contemporânea.
Antimicrobial Activities of Ganoderma mbrekobenum Strain EGDA (Agaricomycetes) from Egypt
Authors: El-Dein Mahmoud M. Nour , El-Fallal Amira A. , El-Sayed Ahmed K. A. , El-Esseily Shimaa R.
Published: July 2023

Ganoderma is a well-known genus of medicinal mushrooms. The biological activity of the fruiting bodies of G. mbrekobenum (previously identified as Ganoderma sp. EGDA, (AC: LN774971) is scarcely studied. The microorganisms
including bacteria and fungi were chosen for screening of the antimicrobial activity produced by G. mbrekobenum
strain EGDA. The bioactive compounds were extracted from aqueous, petroleum ether, chloroform, ethyl acetate, and methanol extracts. The higher antibacterial activity produced by methanol extract was against Bacillus subtilis and B. cereus (14.13 ± 0.12 mm, 13.03 ± 0.12 mm, respectively). Water fraction showed antibacterial effect against most of the test bacterial strains. The highest antifungal activity produced by methanol extract was against Fusarium oxysporum I and F. oxysporum f. sp. lycopersici (16.37 ± 0.03 mm 15.67 ± 0.19 mm, respectively). Gas chromatography/mass spectrometry
analysis of the separated fractions revealed the identification of 46 compounds.
Management of irrigation water in Al-Baha, Saudi Arabia, using a simple alternative to the Penman–Monteith equation
Authors: Alkhuzai Khalid A.
Published: July 2023

Estimating reference crop evapotranspiration (ETo) is very important in the planning and scheduling of irrigation water. A simple method for the estimation of ETo is needed, with fewer meteorological factors that are required for estimation using the Penmen–Monteith equation (PME). The aim of this study was to manage irrigation water in the Al-Baha region of Saudi Arabia using a simple equation to estimate ETo based on air temperature as an effective alternative to the PME. Four simple temperature-dependent equations proposed by Thornthwaite, Blaney-Criddle, Hamon and Linacre were selected for analysis. Of these four equations, the Linacre equation (LE) was found to be best for estimating ETo. Although the ETo rate was overestimated when using the LE compared with the PME, it had the lowest error percentage (9.55%) and the highest R2 (0.97). After deducing a new and accurate equation based on the LE with the ability to estimate the ETo rate, the modified LE produced values closest to the results obtained using the PME for the Al-Baha region. It can thus be relied upon for estimating irrigation needs in the Al-Baha region with the irrigation systems used in the region.
40 anos de cultura galega en estatísticas
Authors:   Consello da Cultura Galega
Published: July 2023

Este informe ten como obxectivo realizar unha comparación e estudo da situación sociocultural de España e Galicia en 1983 con respecto ao ano 2023, coa finalidade de ofrecer unha visión panorámica da evolución da cultura e dos seus estudos estatísticos en Galicia e España, identificando as tendencias, desafíos e ameazas, así como os cambios socioculturais e económicos que se produciron nos últimos 40 anos. Así mesmo, este marco temporal coincide co 40 aniversario do Consello da Cultura Galega, polo que o contido do informe serve tamén como panorámica da evolución da cultura galega durante o tempo de existencia da institución.
Resurrection of the genus Micherdzinskiiobovella Hirschmann, 1989, with the description of M. petofii sp. n. from Singapore (Acari: Mesostigmata: Urodinychidae
Authors: Kontschán Jenő , Ermilov Sergey G.
Published: July 2023

The genus Micherdzinskiiobovella Hirschmann, 1989 (Mesostigmata: Uropodina: Uropodi­nychidae) is resurrected for species of the Uroobovella micherdzinskii-group. This genus differs from the other taxa of the Uroobovella sensu lato based on the shape of body, the first gnathosomal setae, the peritreme and the number of the ventral setae. All species from the Uroobovella micherdzinskii-group are moved to the genus Micherdzinskiiobovella, as M. japonica (Hiramatsu et Hirschmann, 1977) comb. n., M. levigata (Hirschmann et Hiramatsu, 1990) comb. n., M. ma­kilingensis (Hirschmann et Hiramatsu, 1990) comb. n., M. mitakensis (Hiramatsu et Hirschmann, 1977) comb. n., M. pauxilla (Hiramatsu, 1981) comb. n., M. pauxillaoides (Hirschmann, 1981) comb. n., M. similimitakensis (Hirschmann, 1981) comb. n., M. topali (Hirschmann, 1981) comb. n., and M. multisetosa (Kontschán et Starý, 2011) comb. n. A new species (M. petofii sp. n.) is described, based on one female and four males collected from Singapore. The new species differs from the congeners in the length and shape of the ventral setae.
Diseño de imagen de la personalidad del docente en el entorno educativo de la universidad
Authors: Dovga Tetiana Ya , Plachynda Tetiana S. , Zavitrenko Dolores Zh. , Snisarenko Iryna Ye.
Published: July 2023

El análisis del concepto de diseño desde el punto de vista de los enfoques personales y de imagen permitió distinguir las nociones de diseño de imagen y diseño pedagógico en la intersección de las cuales se actualizó el problema del diseño de imagen de una personalidad. El diseño de imagen apareció debido al impacto del diseño en la esfera personal de una persona, y el diseño pedagógico afectó directamente al campo de la educación. En particular, el diseño pedagógico asegura el desarrollo de contenidos innovadores para el entorno educativo y herramientas didácticas, que se caractericen por la eficiencia pedagógica, la adecuación metodológica y la razonabilidad. El propósito del artículo se centró en la imagen de un maestro. La noción de imagen-diseño de la personalidad del docente ha sido formulada y presentada como formación personal y profesional. El primero ha sido revelado a través del prisma del diseño pedagógico y analizado dentro del entorno educativo universitario. Se ha determinado la relación entre la imagen-diseño de un docente, su imagen profesional y su apariencia. Se han analizado las posibilidades de mejorar la apariencia del docente a través del diseño social de la apariencia. Para ello se ha utilizado la noción de imagen-vestimenta, cuyo principal instrumento es el diseño de prendas de vestir, siendo medios acompañantes el etnodiseño y el ecodiseño.
MED-JET H4 MULTIJET (MJH4M) Transfection Protocol v1
Authors: Liu Nathan
Published: July 2023

Transfection, a non-viral method of nucleic acid delivery, often shows poor efficiency in vivo. The needle-based in vivo delivery of transfection reagents can be invasive. Here, we report a non-invasive in vivo gene delivery protocol via the needle-free MED-JET H4 MULTIJET (MJH4M) devices using glucose-based and commercial transfection reagents. The objective of this study is to compare the relative transfection efficiencies of the needle-free system to that of the needle-based delivery method. The highest transfection efficiency was noted using 5% glucose as a delivery agent; a 15-fold increase was observed using MJH4M compared to delivery with needles.
Single cell RNA-seq and ATAC-seq protocol for PBMCs treated with LPS v1
Authors: Luca Francesca
Published: July 2023

Single cell RNA-seq and ATAC-seq protocol for PBMCs treated with LPS
Okunev Culture and the Dene-Caucasian Macrofamily
Authors:   Peter the Great Museum of Anthropology and Ethnography (Kunstkamera), Russian Academy of Sciences, Kozintsev A. G.
Published: July 2023

В статье рассматривается вопрос о языковой принадлежности окуневцев. Приводятся аргументы в пользу того, что они говорили на каком-то языке дене-кавказской макросемьи, относящемся к енисейской ветви. Об этом косвенно свидетельствуют генетические и культурные связи их предков с аборигенами Нового Света, параллели окуневскому искусству в древнем Китае и на северо-западном побережье Северной Америки, а также петроглифы окуневского типа в Северном Кашмире, где сохранился лингвистический изолят в виде бурушаски — языка, родственного енисейским. Будучи реликтовой группой, оставшейся там, откуда дене-кавказские племена мигрировали в разных направлениях, окуневцы могли быть не только предками енисейцев (на эту роль, впрочем, могут претендовать и карасукцы, родство которых с окуневцами предстоит уточнить), но и боковыми родственниками на-дене, сино-тибетцев и других носителей дене-кавказских языков. Альтернативные предположения — о принадлежности языка окуневцев к евразийской макросемье, в частности к самодийской ветви уральской семьи, — по ряду причин менее правдоподобны. Совсем маловероятной кажется индоиранская его принадлежность, являющаяся почти неизбежным следствием гипотезы о решающей роли ямно-катакомбного населения в этногенезе окуневцев. Между тем такое предположение вполне правдоподобно по отношению к чаахольцам Тувы ввиду их чрезвычайно близких краниологических параллелей среди ямных и катакомбных групп, а также скифов восточноевропейских степей. У собственно окуневцев такие параллели не обнаружены.
ADAPTATION PROCEDURE OF THE TEST OF ASSERTIVE BEHAVIOUR
Authors: Makarevičs Valērijs , Iliško Dzintra
Published: July 2023

The problem of assertiveness as a condition of self-actualization is actively developed by both, theorists and  practitioners. In order to explore it,  more than 30 different tests are being developed by the scientists.  However, most of them have common drawback.In reality, behavioural acts that in one cultural environment are perceived as manifestations of assertiveness, in other context it can be interpreted as aggression or perceived as completely unacceptable. The purpose of this study was to select an assertiveness test created in a similar culture, translate it into Latvian and test for reliability. Both, direct and reverse translation was carried out, which was discussed with the author of the test. Repeated pilot testing indicate to  high reliability of a translated version of the test.
RECOGNISING EMOTIONAL ABUSE AND MOBBING IN ADOLESCENTS: CAUSES AND IMPACTS
Authors: Jurs Pāvels , Ročāne Maija , Kulberga Inta , Striguna Santa , Titrek Osman
Published: July 2023

Emotional abuse can cause severe effects on person`s emotional development, e.g., sense of worthlessness, wearing away confidence and self-esteem, anxiety, depression, etc. Psycho-emotional wellbeing becomes essential for the adolescent to become successful at school, which can be reached through emotional support, understanding and self-discovery. Emotional abuse quite often is not recognized, because of possible judgement from family, friends, teachers and community members. Silence about emotional and physical abuse can be the result of fears and emotional abuse situations which can seem as normal for the victim. Therefore, the first step to solve mental problems is becoming aware of a problem and reducing stigma about mental health. Survey results highlight the need for parents to improve their knowledge, attitudes and skills about emotional abuse and understanding of how to communicate with their children about possible emotional abuse situations at schools. Survey results also highlight that one of the main reasons why mobbing occurs is students` attitude towards difference of others e.g. different interests, lifestyle, appearance, clothes, way of communication, sexual orientation, etc.). Using theoretical and empirical research (survey) methods, the aim of the article is: to describe forms of emotional abuse, highlighting the link between emotional abuse and physical abuse and the impact of it on the emotional well-being of adolescent at school. The authors of the article have identified the main problems faced by students, teachers and parents in cases of emotional abuse.
PROFESSIONAL STANDARDS FOR EDUCATIONAL MANAGERS: ANALISING THE EXPERIENCE OF COUNTRIES WITH DIFFERENT SOCIO-ECONOMIC DEVELOPMENT WITH THE VIEW OF ITS POSSIBLE USE IN UKRAINE
Authors: Zadorozhna-Kniahnytska Lenina , Netreba Marina , Holiuk Oksana , Zolotko Julia , Khadzhinova Irina
Published: July 2023

Professional standards for educational managers establish the compliance of a person with the professional requirements; therefore, it is important to study them in order to develop the content of university training programs for school principals. The aim of the present research is to examine the experience of standardization of educational managers’ professional activity in the countries of different socio-economic development and various degrees of participation in the global educational integration processes, as well as to highlight the possible use of best practices to develop and implement the most effective university training programs for educational managers. We conducted the study during 2018 – 2020 according to the methodology of the aspect analysis, having distinguished two aspects: functional and behavioural. We analysed the professional standards within the framework of regional clusters taking as a basis the mutual convergence and interaction of their educational systems, namely regions that are the generators of integration processes; regions that respond positively to integration processes but do not initiate them; regions that are inert to the integration of educational processes. Furthermore, we chose a few countries from each cluster, which adopted the standards at the state level or at the level of individual administrative units within a particular country. The results of the analysis made it possible to identify general and special trends, peculiar to certain groups of countries. The results obtained within the framework of the study made it possible for us to develop the construct of the standard that takes into account the particular features of socio-economic development of Ukraine.
PROMOTING SELF-EFFICACY OF PROSPECTIVE MUSIC TEACHERS: THEORETICAL INSIGHTS
Authors: Bi Guanhua
Published: July 2023

Scientific literature shows that cultivating self-efficacy is conducive to learner in-depth study of music, independent choices and perseverance in the field of music. However, most current research studies focus on self-efficacy in primary and secondary education, whereas the self-efficacy of prospective music teachers has been scarcely investigated. Considering the importance of self-efficacy in music activities of prospective music teachers, a study on the particularity of prospective music teachers’ self-efficacy has been initiated: the literature analysis method has been used, and a large number of literature sources related to self-efficacy and music education have been analysed. The following problem question is formulated: what is the particularity of self-efficacy in music education? The aim of this research is to analyse the concept of self-efficacy in music education. Research results show that self-efficacy determines the judgment of prospective music teachers on their learning, performance, and teaching abilities. Factors that affect the self-efficacy of prospective music teachers include mastery of experiences, vicarious experience, social persuasion, and emotional and psychological states.
PERSPECTIVES ON MUSIC EDUCATION IN ESTONIAN SCHOOLS
Authors: Kaja Kadi , Läänemets Urve , Kiilu Kristi , Kalamees-Ruubel Katrin
Published: July 2023

The content of education at schools meeting the demand for culturally, socially and politically relevant knowledge, skills and competencies for a particular society has remained an issue of debate in all times. Estonia started development of a new national curriculum (NC) in 2020/2021 and both – the content of learning as well as its organization from kindergartens up to the end of gymnasia became a serious issue. The main topic for debates were the proportions of compulsory and optional subjects, especially at the final level (grades 10–12). Music and other art subjects must prove their positions during recent pandemia and military conflicts. The aim of the study is to map expectations of different target groups concerning the future of music education creating the basis for development of music culture in society.The students (n=203) were asked to write essays, analyzing why learning music at high school level is meaningful or not for their personal development. The people responsible for pan-Estonia cultural organizations were interviewed (n=10) and the data were analyzed qualitatively. The results of the study can be used for development of music syllabi in NC of all levels of general education under the present conditions and for teacher training.
THE ROLE OF EMOTIONS IN MUSIC EDUCATION: THEORETICAL INSIGHTS
Authors: Rauduvaitė Asta , Yao Zhiyu
Published: July 2023

Emotional expression has been the focus of teachers and educational researchers, as it can result in an improvement in cognitive performance. In specific settings, personal and emotional experiences can provide a steppingstone to developmental and learning processes. Emotions significantly influence learner learning and play a crucial role in quality teaching, educational reform, and learner-teacher interaction. The inherent social and communicative nature of music would make group training an excellent tool for increasing the coordination of behaviour, affect, and mental states among children. This paper aims to explore the literature on various aspects of the concept of emotions in the context of music education with the main focus on opportunities for experiencing and expressing emotion in music education, learners' positive emotion experiences in music education, teaching to generate positive emotion outcomes, and the benefits of a greater emphasis on the emotions in music education. The results of theoretical analysis indicate that music education has a particularly positive effect on identifying emotions, emotion regulation, emotion recognition, improved learning, and self-expression.
STUDENTS’ DEPTH OF COGNITIVE PERFORMANCE ON SECONDARY SCHOOL STATE MATHEMATICS TESTS
Authors: Mikite Marta , France Ilze
Published: July 2023

Latvia began curriculum reform implementation in 2020. Not only has the learning content changed, but students are also now able to choose from one of three levels to study mathematics in secondary school. This requires new exams at the end of each of these courses. The aim of this study is to investigate student performance and to what extent students can use higher cognitive skills on the new exams. Results were analyzed using Classical Test Theory and Item Response Theory. Comparing the results of the new exams using Wright maps shows a trend that, although there are flaws, they are more representative of the relevant population than the previous exam. A group of experts determined the level of cognition for each of the tasks and analyzed students' performance. The results show that there are tasks where students can demonstrate the highest level of cognitive abilities. However, such tasks are relatively few, and they are mathematical rather than problems in a real context. Performance analysis shows that students have difficulty expressing their thoughts and this is one of the reasons why only a small number of students solve challenging problems
EDUCATORS’ FEEDBACK ON WEBSITE “OVERCOMING STRESS AND ANXIETY TOGETHER: TEACHERS – SCHOOLCHILDREN – PARENTS”
Authors: Kaupuzs Aivars , Malykhin Oleksandr , Aristova Nataliia , Kalvans Eriks , Orska Rita
Published: July 2023

The research aim was to collect feedback from educators on the website “Overcoming Stress and Anxiety Together: Teachers – Schoolchildren – Parents” created within the joint Latvian-Ukrainian project “Web-based Support System for Educators to Reduce Children’s Anxiety in War-affected Areas” (Registration No GPK-07/2022). Immediately after creating a demo version of the website, researchers organised webinars aimed at presenting its content to educators in Ukraine and collected feedback from webinars’ participants. For that very reason the joint Latvian-Ukrainian team of researchers developed a web-based questionnaire using Google Forms. The population of the conducted research comprised 216 educators from different regions of Ukraine including university lecturers, general secondary teachers, researchers and students of pedagogical specialties. The obtained results proved the necessity of developing the web-based support system for educators aimed at reducing anxiety among schoolchildren in war-affected areas in Ukraine.
DEVELOPMENT OF PATIENT-CENTRED HEALTH CARE APPROACH IN THE NURSES’ AND DOCTOR ASSISSTANTS’ EDUCATION
Authors: Jankovska Livija
Published: July 2023

Nowadays the development of health care system focuses on high quality, effective and safe health services which satisfy patients and clients’ needs. Pacient-centred health care approach and strategies are important factors to improve medical care process and results. Nurses and doctor assistants’ education practises should be based on personalised health care approach and principles. The aim of the article is to identify pacient-centred health care components and ways, how to implement them in nurses and doctor’s assisstants education in order to improve knowledge, skills, competences and attitudes for future work in multi-disciplinary team and multi-cultural environment. The study is based on theoretical and methodological analyses of the concepts and education documents. The results: the deeper understanding of the pacient-centred approach and principles, more detailed complex of skills, competences and attitudes appropriate to urgent health care problems and more competent medical worker in the individualized health care system.
APPLYING OF DESIGN THINKING APPROACH IN THE DEVELOPMENT OF FOREIGN LANGUAGE COURSE
Authors: Opincāne Marīte , Laganovska Karīne
Published: July 2023

A lot of people comprehend the necessity to acquire foreign languages and particularly foreign languages for their professional needs, but in most cases, their enthusiasm and motivation decrease and sometimes even disappear when hard work on a regular basis starts.  The greatest advantages of the Design Thinking approach in teaching foreign languages are the development of foreign languages’ competencies and the making of the learners more motivated. The aim of the paper is to analyze the development outcomes of communicative competencies by applying the Design Thinking approach to teaching foreign languages to Bachelor level law students who acquire legal English and Bachelor level Information Technology students who study German as a second foreign language. The following methods were used while doing the research: survey data analysis of the foreign languages courses’ target audience and the qualitative analysis of the data content. A questionnaire of the students was developed and carried out, the answers were processed.  The research experience was analyzed, the conclusions were drawn and the proposals for future work were worked out. The framework of learning was based on the Stanford method: empathizing, defining the problem, ideating, prototyping, and testing. The results of the study proved that the design thinking approach is effective as the learners solve many real-life problems. This encouraged collaboration and activity as they discussed simulated professional and real-life issues. The results also proved that the design thinking approach is recommended for learners with a higher level of foreign language proficiency. The pros and cons of the approach, based on the learners’ results and questionnaires have been summarized.
MEDIATION AS A SKILL IN FOREIGN LANGUAGE CLASSES IN SECONDARY EDUCATION
Authors: Žindžiuvienė Ingrida Egle
Published: July 2023

Although the importance of mediation tasks was introduced in Common European Framework of Reference for Languages: Learning, teaching, assessment (CEFR) in 2001, the development of mediation skills was finally legitimized in the recent edition of CEFR (Council of Europe, 2020). However, the development of this “fifth” language skill during the language classes remains a problematic issue: contrary to the other four language skills (reading, writing, speaking and listening), teachers often face the dilemma of how and when to introduce mediation activities and to what extent mediation should be applied in the process of foreign language teaching and learning. The aim of the research is to survey language teaching policies in Lithuania, Latvia and other EU countries from the aspect of the development of mediation skills in language classes in secondary education. Teaching programs of the English language in senior classes of the secondary school are surveyed from the aspect of mediation skills as defined in the newest edition of CEFR. The research results show that mediation activities are still not adequately included in foreign language classes: first of all, language syllabuses must be adjusted to the revised edition of CEFR. The research has proved the necessity of mediation skills to be included in the secondary education programs of foreign languages. Therefore, the selection of textbooks used in senior classes of foreign languages in secondary education must follow the recommendations outlined in CEFR, where the development of mediation skills is especially emphasized due to the present needs. It has been determined that mediation activities can develop students’ multilingual and plurilingual skills and raise students’ awareness of the peculiarities of both the native language and the foreign one.
INTEGRATION OF NI ELVIS TOOLS INTO THE EDUCATIONAL PROCESS FOR ANALYSIS OF ELECTRONICS SCHEMATICS
Authors: Kozic Antoni , Lucun Andzej , Tumasonis Romanas , Macerauskas Eugenijus , Laukhammer Eivin
Published: July 2023

A receiver circuitry is provided that is primarily controlled by the NI ELVIS instrument and the LabVIEW software package. Thus, it is possible not only to control, but also to process the received signals. This article highlights how easy it is to automate receiver control and receive signal processing with NI ELVIS with LabVIEW. The article presents the practice and perspectives of using the new National Instruments LabVIEW software and NI ELVIS II hardware for teaching in the educational laboratory.