bluuebunny/crossref_metadata_2025 huggingface dataset:
Emotionally engaged or feeling anxious and cynical? School experiences and links to school achievement among Finland-Swedish general and special education students
Authors: Palmgren Marina , Pyhältö Kirsi , Pietarinen Janne , Sullanmaa Jenni , Soini Tiina
Published: September 2021

The aim of the study was to enhance understanding of how seventh graders vary in emotional engagement and experienced well-being at school in terms of anxiety and cynicism. The two profiles were explored, and comparisons were made between students in general education and those in special education. The study participants comprised 119 Finland–Swedish students from five secondary schools. Four emotional-engagement and well-being profiles were identified based on cluster analysis. The students with the most typical profile were moderately engaged in teacher-student interaction and emotionally highly engaged in peer interaction, combined with a low risk of anxiety and cynicism. The profiles showed no statistically significant differences regarding gender and school achievement. However, there were differences between students in special education and those in general education. In Finland, Swedish –speaking Finns are a language minority group. Swedish has official language status in Finland. Compared to many other language minority groups they can be considered somewhat exceptional, since according to many welfare indicators they tend to do better than the general population. There are a few studies on differences between Swedish and Finnish– speaking students’ school experiences in Finland, however, so far studies exploring Swedish- speaking general and special education students’ emotional engagement and study well-being in terms of anxiety and cynicism have been scarce.
Perceptual capacities, discrimination, and the senses
Authors: Hornett William
Published: September 2021

In this paper, I defend a new theory of the nature and individuation of perceptual capacities. I argue that we need a theory of perceptual capacities to explain modal facts about what sorts of perceptual phenomenal states one can be in. I defend my view by arguing for three adequacy constraints on a theory of perceptual capacities: perceptual capacities must be individuated at least partly in terms of their place in a hierarchy of capacities, where these capacities include the senses themselves; an adequate account of perceptual capacities must be sensitive to empirical considerations; and an adequate account should accommodate the nature of the capacity to perceive. I arrive at these constraints by considering how Schellenberg’s view fails, before defending and developing my alternative in line with the constraints. I defend a view on which there are few, coarse-grained perceptual capacities which can fulfil complex explanatory roles because they are evaluatively gradable on many axes. Finally, on my view, perceptual capacities bear a particularly close relation to the sensory modalities themselves.
Influences of landscape structure on butterfly diversity in urban private gardens using a citizen science approach
Authors: Pendl Manfred , Hussain Raja Imran , Moser Dietmar , Frank Thomas , Drapela Thomas
Published: September 2021

Although urbanization is increasing worldwide, private gardens may help mitigate the impact of urbanization on butterfly diversity. We investigated how local and landscape factors correspond with the observed butterfly species diversity and species composition in Viennese private gardens. The goal is to determine the importance of private gardens for butterfly conservation. Butterfly species were observed by skilled volunteers by applying a citizen science approach. We related butterfly species numbers in private gardens with local parameters and landscape composition in a radius of 1 km around each garden. Data were analyzed using a regression approach based on generalized linear models. The butterfly species richness in private gardens was positively correlated with butterfly species richness in the surrounding landscapes. Butterfly species richness in private gardens increased with higher proportions of area relevant for butterflies in the surrounding landscape and with increasing numbers of host and nectar plant species in the private gardens. A higher proportion of wooded areas in the surrounding landscape was related with a smaller proportion of the landscape butterfly species pool being observed in the private gardens. Overall, our results could be useful in land use planning, and for future studies of how to integrate citizen science and make urban gardens more beneficial for butterfly conservation.
Metabolomic signature of amino acids in plasma of patients with non-segmental Vitiligo
Authors: Marzabani Rezvan , Rezadoost Hassan , Choopanian Peyman , Kolahdooz Sima , Mozafari Nikoo , Mirzaie Mehdi , Karimi Mehrdad , Nieminen Anni I. , Jafari Mohieddin
Published: September 2021

Introduction

Vitiligo pathogenesis is complicated, and several possibilities were suggested. However, it is well-known that the metabolism of pigments plays a significant role in the pathogenicity of the disease.

Objectives

We explored the role of amino acids in vitiligo using targeted metabolomics.

Methods

The amino acid profile was studied in plasma using liquid chromatography. First, 22 amino acids were derivatized and precisely determined. Next, the concentrations of the amino acids and the molar ratios were calculated in 31 patients and 34 healthy individuals.

Results

The differential concentrations of amino acids were analyzed and eight amino acids, i.e., cysteine, arginine, lysine, ornithine, proline, glutamic acid, histidine, and glycine were observed differentially. The ratios of cysteine, glutamic acid, and proline increased significantly in Vitiligo patients, whereas arginine, lysine, ornithine, glycine, and histidine decreased significantly compared to healthy individuals. Considering the percentage of skin area, we also showed that glutamic acid significantly has a higher amount in patients with less than 25% involvement compared to others. Finally, cysteine and lysine are considered promising candidates for diagnosing and developing the disorder with high accuracy (0.96).

Conclusion

The findings are consistent with the previously illustrated mechanism of Vitiligo, such as production deficiency in melanin and an increase in immune activity and oxidative stress. Furthermore, new evidence was provided by using amino acids profile toward the pathogenicity of the disorder.
Six weeks of high-intensity interval training enhances contractile activity induced vascular reactivity and skeletal muscle perfusion in older adults
Authors: Herrod Philip J. J. , Atherton Philip J. , Smith Kenneth , Williams John P. , Lund Jonathan N. , Phillips Bethan E.
Published: September 2021

Impairments in muscle microvascular function are associated with the pathogenesis of sarcopenia and cardiovascular disease. High-intensity interval training (HIIT) is an intervention by which a myriad of beneficial skeletal muscle/cardiovascular adaptations have been reported across age, including capillarisation and improved endothelial function. Herein, we hypothesised that HIIT would enhance muscle microvascular blood flow and vascular reactivity to acute contractile activity in older adults, reflecting HIIT-induced vascular remodelling. In a randomised controlled-trial, twenty-five healthy older adults aged 65–85 years (mean BMI 27.0) were randomised to 6-week HIIT or a no-intervention control period of an equal duration. Measures of microvascular responses to a single bout of muscle contractions (i.e. knee extensions) were made in the m. vastus lateralis using contrast-enhanced ultrasound during a continuous intravenous infusion of Sonovue™ contrast agent, before and after the intervention period, with concomitant assessments of cardiorespiratory fitness and resting blood pressure. HIIT led to improvements in anaerobic threshold (13.2 ± 3.4 vs. 15.3 ± 3.8 ml/kg/min, P < 0.001), dynamic exercise capacity (145 ± 60 vs. 159 ± 59 W, P < 0.001) and resting (systolic) blood pressure (142 ± 15 vs. 133 ± 11 mmHg, P < 0.01). Notably, HIIT elicited significant increases in microvascular blood flow responses to acute contractile activity (1.8 ± 0.63 vs. 2.3 ± 0.8 (arbitrary contrast units (AU), P < 0.01)), with no change in any of these parameters observed in the control group. Six weeks HIIT improves skeletal muscle microvascular responsiveness to acute contractile activity in the form of active hyperaemia-induced by a single bout of resistance exercise. These findings likely reflect reports of enhanced large vessel distensibility, improved endothelial function, and muscle capillarisation following HIIT. Moreover, our findings illustrate that HIIT may be effective in mitigating deleterious alterations in muscle microvascular mediated aspects of sarcopenia.
The influence of individual characteristics on getting involved in an entrepreneurial team: The contingent role of individualism
Authors: Pinzón Nathaly , Montero Javier , González-Pernía José L.
Published: September 2021

A traditional stereotype of the entrepreneur is that of a lone hero. However, many entrepreneurs engage in new businesses as members of entrepreneurial teams. These teams usually perform better in terms of employment generation, innovation, and profits. Thus, a relevant question is why some individuals get involved in entrepreneurship through a team rather than alone. Our explanation is focused on two variables related to the entrepreneur’s human capital: their educational level and their intrapreneurial experience. There are conflicting arguments on how these variables lead an entrepreneur to join a team, and we argue that the degree of individualism of the society helps us understand the discrepancies. We use a sample of 66,716 early-stage entrepreneurs from 66 countries surveyed by the Global Entrepreneurship Monitor between 2014 and 2017. Our results show that entrepreneurs with higher levels of education and intrapreneurial experience are more likely to be involved in the entrepreneurship process as members of teams. However, the effect of educational level is less pronounced in individualist contexts. In addition, we find that the motivation to enter entrepreneurship partially mediates these relationships, as individuals endowed with higher human capital are likely to enter entrepreneurship driven by an opportunistic motivation, which in turns makes them likely to need or join teams to reach their goals.
Serviceability analysis of piled foundations supporting tall structures
Authors: Iovino Maria , Di Laora Raffaele , de Sanctis Luca
Published: September 2021

Pile foundations supporting tall structures, such as wind turbines, chimneys, silos, elevated water tanks or bridge piers, are subjected during their life span to remarkably eccentric loads. These may lead to significant rotations which, however, cannot exceed the limiting values corresponding to the safe operation of the structure. A physically motivated mathematical framework aimed at the prediction of the serviceability performance of such kind of structures is herein presented and discussed. Piles are idealized as uniaxial nonlinear elements characterized by two yielding loads, one in compression and one in uplift, while pile-to-pile interaction effects are modeled by means of superposition, through an approximate solution. The axial load–moment capacity of the pile group is preliminary determined from a recent closed form, exact solution based on upper and lower bound theorems, allowing the analysis to be performed under load control. The model is capable of accounting for the dependence of the moment–rotation response from the dead load of the structure and the ‘coupling effect’ between generalized loads and displacements. The prediction performance of the proposed calculation method is validated against both numerical and experimental benchmarks. Finally, a parametric study allowed to assess the importance of pile-to-pile interaction on the foundation response under eccentric loads.
Quantitative but not qualitative flavor recognition impairments in COVID-19 patients
Authors: Nettore Immacolata Cristina , Cantone Elena , Palatucci Giuseppe , Franchini Fabiana , Maturi Rufina , Nerilli Mariagiovanna , Manzillo Elio , Foggia Maria , Maione Luigi , Ungaro Paola , Colao Annamaria , Macchia Paolo Emidio
Published: September 2021

Background

Smell and taste dysfunctions (STDs) are symptoms associated with COVID-19 syndrome, even if their incidence is still uncertain and variable.

Aims

In this study, the effects of SARS-CoV-2 infection on chemosensory function have been investigated using both a self-reporting questionnaire on smell and flavor perception, and a simplified flavor test.

Methods

A total of 111 subjects (19 hospitalized [HOS] and 37 home-isolated [HI] COVID-19 patients, and 55 healthy controls [CTRL]) were enrolled in the study. They received a self-evaluation questionnaire and a self-administered flavor test kit. The flavor test used consists in the self-administration of four solutions with a pure olfactory stimulus (coffee), a mixed olfactory-trigeminal stimulus (peppermint), and a complex chemical mixture (banana).

Results

After SARS-CoV-2 infection, HOS and HI patients reported similar prevalence of STDs, with a significant reduction of both smell and flavor self-estimated perception. The aromas of the flavor test were recognized by HI and HOS COVID-19 patients similarly to CTRL; however, the intensity of the perceived aromas was significantly lower in patients compared to controls.

Conclusion

Data reported here suggests that a chemosensory impairment is present after SARS-CoV-2 infection, and the modified “flavor test” could be a novel self-administering objective screening test to assess STDs in COVID-19 patients.

Clinical trial registration no. NCT04840966; April 12, 2021, retrospectively registered
Spider Neurotoxins as Modulators of NMDA Receptor Signaling
Authors: Pałasz Artur , Krzystanek Marek
Published: September 2021

Molecules that selectively act on N-methyl-D-aspartate (NMDA) receptors may have a multidirectional effect by modulating the activity of NMDARs, affecting their active sites as well as by changing the composition of their subunits. The results of the clinical trials conducted so far in mood disorders and schizophrenia indicate that such agents may become new effective drugs for the treatment of these diseases. Number of spider neurotoxins e.g. ctenitoxins extracted from Phoneutria sp. venom act as potent and selective NMDAR blockers that do not disturb cortical and hippocampal glutamate signaling, LTP generation and synaptic neurochemistry. Possibly this intriguing kind of promising neuroregulatory peptides and polyamines can be clinically applicable in a wide spectrum of neuropsychiatric disorders, including epilepsy, neurotrauma and ischemic injuries. These novel medications can potentially be helpful in the future treatment of stroke and several neurodegenerative diseases.
The Semiotic Approach to Bacterial Chemotaxis
Authors: Kłóś Adam , Płonka Przemysław Mieszko
Published: September 2021

Bacterial chemotaxis is often considered to be a textbook example of the rudimentary semiotic process. As such, it gives an excellent opportunity to better understand both semiosis and biology. Our study reviews this phenomenon in the light of up-to-date scientific knowledge to answer the most basic semiotic questions: what is the sign? What types of signs are there? What is the meaning understood on the molecular level, and by what means can it grow with time? As a case study, the bacterial chemotaxis toward glucose in E. coli species is chosen, and the semiotic framework of Charles Sanders Peirce applied. The analyses provide us with the following results: the sign, in its ultimate nature, is a general process. Bacterial chemotaxis can be understood in terms of Peircean type, symbol, and argument. The meaning on the molecular level is entirely pragmatic and, in this case, reduced to a bacterial response to glucose. A sign can grow through sign generalization, the emergence of different sign categories, the integration of these categories in functional cycles, and the introduction of contextuality. The sign of bacterial chemotaxis extends from the cell signaling pathways up to the population level. The presented results advance our knowledge of sign processing in the context of semiotic evolution.
How Molecules Became Signs
Authors: Deacon Terrence W.
Published: September 2021

To explore how molecules became signs I will ask: “What sort of process is necessary and sufficient to treat a molecule as a sign?” This requires focusing on the interpreting system and its interpretive competence. To avoid assuming any properties that need to be explained I develop what I consider to be a simplest possible molecular model system which only assumes known physics and chemistry but nevertheless exemplifies the interpretive properties of interest. Three progressively more complex variants of this model of interpretive competence are developed that roughly parallel an icon-index-symbol hierarchic scaffolding logic. The implication of this analysis is a reversal of the current dogma of molecular and evolutionary biology which treats molecules like DNA and RNA as the original sources of biological information. Instead I argue that the structural characteristics of these molecules have provided semiotic affordances that the interpretive dynamics of viruses and cells have taken advantage of. These molecules are not the source of biological information but are instead semiotic artifacts onto which dynamical functional constraints have been progressively offloaded during the course of evolution.
Geostatistical modeling of porosity and evaluating the local and global distribution
Authors: GhojehBeyglou MohammadHossein
Published: September 2021

Porosity is one of the main variables needed for reservoir characterization. For this volumetric variable, there are many methods to simulate the spatial distribution. In this article, porosity was analyzed and modeled in the local and global distribution. For simulation, Sequential Gaussian simulation (SGS) and Gaussian Random Function (GRFS) were applied. Also, kriging was used to estimate the porosity at specific locations. The main purpose of this work was to investigate the porosity to compare geostatistical simulation and estimation methods in a sandstone reservoir as a real case study. First, the data sets were normalized by the Normal Scores Transformation (NST) and stratigraphic coordinate. The model of experimental variograms was fitted in the vertical and horizontal directions. For the simulation methods, 10 realizations were generated by each method. The Q-Q plots were calculated, and both sets of quintiles (Target Porosity Distribution versus Porosity realization) came from normal distributions with the following correlation coefficients: 0.93, 0.94 and 0.97 related to GRFS, SGS and Kriging, respectively. The extracted variograms from realizations showed that the kriging couldn’t reproduce the variograms with global distribution. For local validation, the cross-validation was evaluated and three wells were omitted. The re-estimation of porosity was considered at located well logs through the well sections window where the kriging had a better performance with minimum error to estimate porosity locally. Finally, the cross-sectional models were generated by each algorithm which showed that the simple kriging tries to produce smoother distribution, whereas conditional simulations (SGS and GRFS) try to represent more global-detailed sections.
The innate aptitude’s effect on the surgical task performance: a systematic review
Authors: El Boghdady Michael , Ewalds-Kvist Beatrice Marianne
Published: September 2021

Surgery is known to be a craft profession requiring individuals with specific innate aptitude for manipulative skills, and visuospatial and psychomotor abilities. The present-day selection process of surgical trainees does not include aptitude testing for the psychomotor and manual manipulative skills of candidates for required abilities. We aimed to scrutinize the significance of innate aptitudes in surgical practice and impact of training on skills by systematically reviewing their significance on the surgical task performance. A systematic review was performed in compliance with PRISMA guidelines. An initial search was carried out on PubMed/Medline for English language articles published over 20 years from January 2001 to January 2021. Search strategy and terms to be used included ‘aptitude for surgery’, ‘innate aptitude and surgical skills, ‘manipulative abilities and surgery’, and ‘psychomotor skills and surgery’. MERSQI score was applied to assess the quality of quantitatively researched citations. The results of the present searches provided a total of 1142 studies. Twenty-one studies met the inclusion criteria out of which six citations reached high quality and rejected our three null hypothesis. Consequently, the result specified that all medical students cannot reach proficiency in skills necessary for pursuing a career in surgery; moreover, playing video games and/or musical instruments does not promote skills for surgery, and finally, there may be a valid test with predictive value for novices aspiring for a surgical career. MERSQI mean score was 11.07 (SD = 0.98; range 9.25–12.75). The significant findings indicated that medical students with low innate aptitude cannot reach skills necessary for a competent career in surgery. Training does not compensate for pictorial-skill deficiency, and a skill is needed in laparoscopy. Video-gaming and musical instrument playing did not significantly promote aptitude for microsurgery. The space-relation test has predictive value for a good laparoscopic surgical virtual-reality performance. The selection process for candidates suitable for a career in surgery requests performance in a simulated surgical environment.
Spatio-temporal joint aberrance suppressed correlation filter for visual tracking
Authors: Xu Libin , Kim Pyoungwon , Wang Mengjie , Pan Jinfeng , Yang Xiaomin , Gao Mingliang
Published: September 2021

The discriminative correlation filter (DCF)-based tracking methods have achieved remarkable performance in visual tracking. However, the existing DCF paradigm still suffers from dilemmas such as boundary effect, filter degradation, and aberrance. To address these problems, we propose a spatio-temporal joint aberrance suppressed regularization (STAR) correlation filter tracker under a unified framework of response map. Specifically, a dynamic spatio-temporal regularizer is introduced into the DCF to alleviate the boundary effect and filter degradation, simultaneously. Meanwhile, an aberrance suppressed regularizer is exploited to reduce the interference of background clutter. The proposed STAR model is effectively optimized using the alternating direction method of multipliers (ADMM). Finally, comprehensive experiments on TC128, OTB2013, OTB2015 and UAV123 benchmarks demonstrate that the STAR tracker achieves compelling performance compared with the state-of-the-art (SOTA) trackers.
Imperatives of recognising the complexities: gendered impacts and responses to COVID-19 in India
Authors: Agarwal Bina
Published: September 2021

This paper argues that the gendered impact of COVID-19 has both visible and hidden dimensions, and both immediate effects linked with lockdowns and longer-term effects that are likely to emerge sequentially in time and affect recovery. Much of the existing feminist literature on the impact of COVID-19 has neglected these complexities and focused mainly on care work and domestic violence. This has diverted attention away from other key concerns such as livelihood loss, food and nutritional insecurity, indebtedness, rising poverty, and the low resilience of most women in developing economies. Even care work and domestic violence have complex facets that tend to be missed. Using examples from India, the paper outlines the kinds of gendered effects we might expect, the extent to which these have been traced in existing surveys, and the data gaps. It also highlights the potential of group approaches in enhancing women’s economic recovery and providing social protection from the worst outcomes of the pandemic—approaches that could guide us towards effective policy pathways for ‘building back better.’
Spatio-temporal clustering of earthquakes based on distribution of magnitudes
Authors: Yamagishi Yuki , Saito Kazumi , Hirahara Kazuro , Ueda Naonori
Published: September 2021

It is expected that the pronounced decrease inb-value of the Gutenberg–Richter law for some region during some time interval can be a promising precursor in forecasting earthquakes with large magnitudes, and thus we address the problem of automatically identifying such spatio-temporal change points as several clusters consisting of earthquakes whoseb-values are substantially smaller than the total one. For this purpose, we propose a new method consisting of two phases: tree construction and tree separation. In the former phase, we employ one of two different declustering algorithms called single-link and correlation-metric developed in the field of seismology, while in the later phase, we employ a variant of the change-point detection algorithm, developed in the field of data mining. In the later phase, we also employ one of two different types of objective functions, i.e., the average magnitude which is inversely proportional to theb-value, and the likelihood function based on the Gutenberg–Richter law. Here note that since the magnitudes of most earthquakes are relatively small, we formulate our problem so as to produce one relatively large cluster and the other small clusters having substantially larger average magnitudes or smallerb-values. In addition, in order to characterize some properties of our proposed methods, we present a method of analyzing magnitude correlation over an earthquake network. In our empirical evaluation using earthquake catalog data covering the whole of Japan, we show that our proposed method employing the single-link strategy can produce more desirable results for our purpose in terms of the improvement of weighted sums of variances, average logarithmic likelihoods, visualization results, and magnitude correlation analyses.
Refugee Integration and Globalization: Ugandan and Zimbabwean Perspectives
Authors: Wamara Charles Kiiza , Muchacha Munyaradzi , Ogwok Benard , Dudzai Cornelius
Published: September 2021

This article examines refugee integration in a globalizing world through the example of the efforts made, and challenges faced, by refugees, communities, and governments in Zimbabwe and Uganda. Using documentary analysis, the article shows how the two countries have striven to integrate refugees through encampment and non-camp settlement policies despite structural challenges such as restrictions on movement, economic crises, high unemployment, and limited state funding and resources. The article begins by conceptualizing globalization and integration and then reviews the perspectives on refugee integration in the two countries. It concludes with some recommendations to improve refugee integration in both countries.
Development of a Plasma Chemistry Model for Helicon Plasma Thruster analysis
Authors: Majorana Enrico , Souhair Nabil , Ponti Fabrizio , Magarotto Mirko
Published: September 2021

The present work is part of a wider project aimed at improving the description of the plasma dynamics during the production phase of a Helicon Plasma Thruster. In particular, the work was focused on the development of a chemical model for Argon- and Xenon-based plasma. The developed model consists of a collisional radiative model suitable to describe the dynamics of the 1s and 2p excited levels. The model is meant to be complementary to 3D-VIRTUS, a numerical tool which enforces a fluid description of plasma, developed by the University of Padova to analyse helicon discharges. Once identified, the significant reactions for both propellants, the reaction rate coefficients, have been integrated exploiting cross sections from literature and assuming a Maxwellian velocity distribution function for all the species. These coefficients have been validated against experimental measurements of an Argon Inductively Coupled Plasma and compared with a well-established code. For Argon, the selected reactions have been reduced through a proposed lumping methodology. In this way, it was possible to reduce the number of equations of the system to solve, and implement them into 3D-VIRTUS. A validation against an experimental case taken from literature was performed, showing good agreement of the results. Regarding the Xenon model, only a verification has been performed against the results of another collisional-radiative model in literature. Finally, a predictive analysis of the propulsive performances of a Helicon Plasma Thruster for both Argon and Xenon is presented.
Conjuring the Ghost: A Call and Response to Haints
Authors: brown drea
Published: September 2021

This article discusses haunting as a condition and strategy for Black women in their lived and literary experiences. I use the haint as a key figure for understanding Black women's liminal state as both the ones haunted and the thing haunting and focus on one of the haint's primary manifestations: the hag. Throughout the essay I unpack maligning myths of this specter and center the works of Phillis Wheatley and Lucille Clifton to refigure the hag as a spiritual and ancestral presence.
Effects of phase difference between instability modes on boundary-layer transition
Authors: Kim Minwoo , Kim Seungtae , Lim Jiseop , Lin Ray-Sing , Jee Solkeun , Park Donghun
Published: September 2021

Phase effect on the modal interaction of flow instabilities is investigated for laminar-to-turbulent transition in a flat-plate boundary-layer flow. Primary and secondary three-dimensional (3-D) oblique waves at various initial phase differences between these two instability modes. Three numerical methods are used for a systematic approach for the entire transition process, i.e. before the onset of transition well into fully turbulent flow. Floquet analysis predicts the subharmonic resonance where a subharmonic mode locally resonates for a given basic flow composed of the steady laminar flow and the fundamental mode. Because Floquet analysis is limited to the resonating subharmonic mode, nonlinear parabolised stability equation analysis (PSE) is conducted with various phase shifts of the subharmonic mode with respect to the given fundamental mode. The application of PSE offers insights on the modal interaction affected by the phase difference up to the weakly nonlinear stage of transition. Large-eddy simulation (LES) is conducted for a complete transition to turbulent boundary layer because PSE becomes prohibitively expensive in the late nonlinear stage of transition. The modulation of the subharmonic resonance with the initial phase difference leads to a significant delay in the transition location up to

$\Delta Re_{x, tr} \simeq 4\times 10^5$

as predicted by the current LES. Effects of the initial phase difference on the spatial evolution of the modal shape of the subharmonic mode are further investigated. The mechanism of the phase evolution is discussed, based on current numerical results and relevant literature data.
Intergenerational differences in dietary acculturation among Ghanaian immigrants living in New York City: a qualitative study
Authors: Horlyck-Romanovsky Margrethe F. , Huang Terry T.-K. , Ahmed Ramatu , Echeverria Sandra E. , Wyka Katarzyna , Leung May May , Sumner Anne E. , Fuster Melissa
Published: September 2021

Dietary acculturation may explain the increasing risk of diet-related diseases among African immigrants in the United States (US). We interviewed twenty-five Ghanaian immigrants (Youthn13, Age (Mean ±sd) 20 y ± 5⋅4, Parents (n6) and Grandparents (n6) age 58⋅7 ± 9⋅7) living in New York City (NYC) to (a) understand how cultural practices and the acculturation experience influence dietary patterns of Ghanaian immigrants and (b) identify intergenerational differences in dietary acculturation among Ghanaian youth, parents and grandparents. Dietary acculturation began in Ghana, continued in NYC and was perceived as a positive process. At the interpersonal level, parents encouraged youth to embrace school lunch and foods outside the home. In contrast, parents preferred home-cooked Ghanaian meals, yet busy schedules limited time for cooking and shared meals. At the community level, greater purchasing power in NYC led to increased calories, and youth welcomed individual choice as schools and fast food exposed them to new foods. Global forces facilitated nutrition transition in Ghana as fast and packaged foods became omnipresent in urban settings. Adults sought to maintain cultural foodways while facilitating dietary acculturation for youth. Both traditional and global diets evolved as youth and adults adopted new food and healthy social norms in the US.
Characterisation of body size phenotypes in a middle-aged Maltese population
Authors: Agius Rachel , Pace Nikolai Paul , Fava Stephen
Published: September 2021

Obesity is increasingly recognised as being a heterogeneous disease. Some obese individuals may present a metabolically healthy profile (metabolically healthy obese (MHO)), while some normal weight individuals exhibit an adverse cardiometabolic phenotype (metabolically unhealthy normal weight individuals (MUHNW)). The objectives of the present study were to examine the prevalence and associated characteristics of the different body composition phenotypes within a Maltese cohort. This was a cross-sectional analysis involving 521 individuals aged 41 ± 5 years. The metabolically unhealthy state was defined as the presence of ≥2 metabolic syndrome components (NCEP-ATPIII parameters), while individuals with ≤1 cardiometabolic abnormalities were classified as metabolically healthy. Overall, 70 % of the studied population was overweight or obese and 30⋅7 % had ≥2 cardiometabolic abnormalities. The prevalence of MHO and MUHNW was 10⋅7 and 2⋅1 %, respectively. Individuals with the healthy phenotype were more likely to consume alcohol, participate in regular physical activity and less likely to be smokers. While the MHO phenotype had similar values for waist, hip and neck circumferences, waist–hip ratio and insulin resistance when compared with MUHNW individuals, there was a lower proportion of MHO subjects having a high fasting plasma glucose, hypertriglyceridaemia or low HDL-C when compared with the unhealthy lean individuals. A high prevalence of the metabolically unhealthy phenotype was observed in this relatively young population which may result in significant future cardiovascular disease burden if timely assessment and management of modifiable risk factors are not implemented. Furthermore, the present study suggests that the MHO phenotype is not totally benign as previously thought.
In vitro effects of nutraceutical treatment on human osteoarthritic chondrocytes of females of different age and weight groups
Authors: Amr Mahmoud , Mallah Alia , Abusharkh Haneen , Van Wie Bernard , Gozen Arda , Mendenhall Juana , Idone Vincent , Tingstad Edwin , Abu-Lail Nehal I.
Published: September 2021

The in vitro effects of four nutraceuticals, catechin hydrate, gallic acid, α-tocopherol and ascorbic acid, on the ability of human osteoarthritic chondrocytes of two female obese groups to form articular cartilage (AC) tissues and to reduce inflammation were investigated. Group 1 represented thirteen females in the 50–69 years old range, an average weight of 100 kg and an average body mass index (BMI) of 34⋅06 kg/m2. Group 2 was constituted of three females in the 70–80 years old range, an average weight of 75 kg and an average BMI of 31⋅43 kg/m2. The efficacy of nutraceuticals was assessed in monolayer cultures using histological, colorimetric and mRNA gene expression analyses. AC engineered tissues of group 1 produced less total collagen and COL2A1 (38-fold), and higher COL10A1 (2⋅7-fold), MMP13 (50-fold) and NOS2 (15-fold) mRNA levels than those of group 2. In comparison, engineered tissues of group 1 had a significant decrease in NO levels from day 1 to day 21 (2⋅6-fold), as well as higher mRNA levels of FOXO1 (2-fold) and TNFAIP6 (16-fold) compared to group 2. Catechin hydrate decreased NO levels significantly in group 1 (1⋅5-fold) while increasing NO levels significantly in group 2 (3⋅8-fold). No differences from the negative control were observed in the presence of other nutraceuticals for either group. In conclusion, engineered tissues of the younger but heavier patients responded better to nutraceuticals than those from the older but leaner study participants. Finally, cells of group 2 formed better AC tissues with less inflammation and better extracellular matrix than cells of group 1.
Rewriting the Virgilian Career: The Scaligers and theAppendix Vergiliana
Authors: Brammall Sheldon
Published: September 2021

Renaissance scholars agreed that Virgil's canon included poems beyond the “Eclogues,” “Georgics,” and “Aeneid,” but the number of other authentic poems and their value were matters of debate. This article charts competing readings of the “Appendix Vergiliana” by Julius Caesar Scaliger and Joseph Justus Scaliger. Pseudo-Virgilian poems played a key role in J. C. Scaliger's “Poetices Libri Septem” (1561), providing a model of self-quotation and self-emulation for young poets to imitate. In a groundbreaking edition, J. J. Scaliger then discovers a neoteric, Catullan side to Virgil. Their influential readings of the “Appendix” offer radically revised conceptions of the Virgilian poetic career.
Starting with People Where They Are: Ella Baker’s Theory of Political Organizing
Authors: INOUYE MIE
Published: September 2021

This article argues that Ella Baker’s ideology of radical democracy shaped her theory of organizing, including her theories of mass action and indigenous leadership. Against the emerging consensus in realist and radical democratic theory that both Baker’s praxis and democratic organizing more broadly are nonideological, I argue that all organizing is ideological if, with Stuart Hall, we understand ideology not as a rigid set of beliefs but as a dynamic framework for understanding society. Organizers make decisions based on their own ideologies and they attempt to maintain or reshape the dominant ideologies. In this sense, organizers are political theorists: they have self-conscious theories of how society works and changes based on which they make strategic decisions. I demonstrate a method for interpreting organizers’ political theories and argue that Baker’s theory of radical democracy offers democratic theory insight into the practices and organizational structures that advance democratization.
Comprehensive HIV/AIDS knowledge and safer sex negotiation among adolescent girls and young women in sub-Saharan Africa
Authors: Frimpong James Boadu , Budu Eugene , Adu Collins , Mohammed Aliu , Tetteh Justice Kanor , Seidu Abdul-Aziz , Ahinkorah Bright Opoku
Published: September 2021

Globally, HIV/AIDS remains a public health issue, especially in sub-Saharan Africa (SSA). Despite the increased advocacy and dissemination of comprehensive HIV/AIDS information in SSA, it appears that little progress has been made to reduce the incidence of HIV/AIDS in the sub-region. This study, therefore, examined the association between comprehensive HIV/AIDS knowledge and safer sex negotiation among adolescent girls and young women in SSA. Data were taken from the Demographic and Health Surveys conducted between 2010 and 2019 in 30 countries in SSA. The study sample comprised 37,364 adolescent girls and young women aged 15–24. A multivariable binary logistic regression analysis was done to test the hypothesis that there is a positive association between comprehensive HIV/AIDS knowledge and safer sex negotiation. Adolescent girls and young women who had comprehensive knowledge on HIV/AIDS were more likely to negotiate for safer sex compared with those who had no comprehensive knowledge on HIV/AIDS (AOR=1.31, 95% CI: 1.22–1.41). At the country level, the positive association between comprehensive knowledge on HIV/AIDS and safer sex negotiation was significant in Chad, Congo DR, Gambia, Guinea, Liberia, Ethiopia and Malawi. On the other hand, in Togo, adolescent girls and young women who had comprehensive HIV/AIDS knowledge were less likely to negotiate for safer sex. These findings can inform policies and programmes on the crucial role of comprehensive HIV/AIDS education and knowledge in increasing safer sex negotiation among adolescent girls and young women in SSA. The study recommends that Togo needs to address certain practices such as intimate partner violence against adolescent girls and young women, which prevent them from negotiating for safer sex, despite their higher knowledge on comprehensive HIV/AIDS. Lessons can be learnt from Chad, Congo DR, Gambia, Guinea, Liberia, Ethiopia and Malawi about the scale-up of programmes and interventions targeted at young women.
Strong complete minors in digraphs
Authors: Axenovich Maria , Girão António , Snyder Richard , Weber Lea
Published: September 2021

Kostochka and Thomason independently showed that any graph with average degree
$\Omega(r\sqrt{\log r})$
contains a
$K_r$
minor. In particular, any graph with chromatic number
$\Omega(r\sqrt{\log r})$
contains a
$K_r$
minor, a partial result towards Hadwiger’s famous conjecture. In this paper, we investigate analogues of these results in the directed setting. There are several ways to define a minor in a digraph. One natural way is as follows. A strong
$\overrightarrow{K}_{\!\!r}$
minor is a digraph whose vertex set is partitioned into r parts such that each part induces a strongly connected subdigraph, and there is at least one edge in each direction between any two distinct parts. We investigate bounds on the dichromatic number and minimum out-degree of a digraph that force the existence of strong
$\overrightarrow{K}_{\!\!r}$
minors as subdigraphs. In particular, we show that any tournament with dichromatic number at least 2r contains a strong
$\overrightarrow{K}_{\!\!r}$
minor, and any tournament with minimum out-degree
$\Omega(r\sqrt{\log r})$
also contains a strong
$\overrightarrow{K}_{\!\!r}$
minor. The latter result is tight up to the implied constant and may be viewed as a strong-minor analogue to the classical result of Kostochka and Thomason. Lastly, we show that there is no function
$f\;:\;\mathbb{N} \rightarrow \mathbb{N}$
such that any digraph with minimum out-degree at least f(r) contains a strong
$\overrightarrow{K}_{\!\!r}$
minor, but such a function exists when considering dichromatic number.
Standard CPR versus interposed abdominal compression CPR in shunted single ventricle patients: comparison using a lumped parameter mathematical model
Authors: Stromberg Daniel , Carvalho Karen , Marsden Alison , Mery Carlos M. , Immanuel Camille , Mizrahi Michelle , Yang Weiguang
Published: September 2021

Introduction:

Cardiopulmonary resuscitation (CPR) in the shunted single-ventricle population is associated with poor outcomes. Interposed abdominal compression-cardiopulmonary resuscitation, or IAC-CPR, is an adjunct to standard CPR in which pressure is applied to the abdomen during the recoil phase of chest compressions.

Methods:

A lumped parameter model that represents heart chambers and blood vessels as resistors and capacitors was used to simulate blood flow in both Blalock-Taussig-Thomas and Sano circulations. For standard CPR, a prescribed external pressure waveform was applied to the heart chambers and great vessels to simulate chest compressions. IAC-CPR was modelled by adding phasic compression pressure to the abdominal aorta. Differential equations for the model were solved by a Runge-Kutta method.

Results:

In the Blalock-Taussig-Thomas model, mean pulmonary blood flow during IAC-CPR was 30% higher than during standard CPR; cardiac output increased 21%, diastolic blood pressure 16%, systolic blood pressure 8%, coronary perfusion pressure 17%, and coronary blood flow 17%. In the Sano model, pulmonary blood flow during IAC-CPR increased 150%, whereas cardiac output was improved by 13%, diastolic blood pressure 18%, systolic blood pressure 8%, coronary perfusion pressure 15%, and coronary blood flow 14%.

Conclusions:

In this model, IAC-CPR confers significant advantage over standard CPR with respect to pulmonary blood flow, cardiac output, blood pressure, coronary perfusion pressure, and coronary blood flow. These results support the notion that single-ventricle paediatric patients may benefit from adjunctive resuscitation techniques, and underscores the need for an in-vivo trial of IAC-CPR in children.
Design and Construction of an Optical TEM Specimen Holder
Authors: Martis Joel , Zhang Ze , Li Hao-Kun , Marshall Ann , Kim Roy , Majumdar Arun
Published: September 2021

Electron microscopy has enabled atomic resolution imaging of matter. However, unlike optical spectroscopic imaging, traditional electron microscopes provide limited spectroscopic information in terms of their energy resolution. Only recently, owing to advances in monochromated STEM-EELS, have transmission electron microscopes (TEMs) been able to attain a high energy resolution. We recently proposed combining spectrally selective photoexcitation with HRTEM to achieve sub-nanometer scale optical imaging, a technique we called photoabsorption microscopy using electron analysis (PAMELA). To realize PAMELA-TEM experimentally, we constructed a TEM holder with an optical feedthrough, capable of photoexciting materials with different wavelengths. In this article, we describe our process for designing and fabricating an optical TEM specimen holder, highlighting important aspects of the design.
Probabilistic Evaluation of Drought in CMIP6 Simulations
Authors: Papalexiou Simon Michael , Rajulapati Chandra Rupa , Andreadis Konstantinos M. , Foufoula‐Georgiou Efi , Clark Martyn P. , Trenberth Kevin E.
Published: September 2021

As droughts have widespread social and ecological impacts, it is critical to develop long‐term adaptation and mitigation strategies to reduce drought vulnerability. Climate models are important in quantifying drought changes. Here, we assess the ability of 285 CMIP6 historical simulations, from 17 models, to reproduce drought duration and severity in three observational data sets using the Standardized Precipitation Index (SPI). We used summary statistics beyond the mean and standard deviation, and devised a novel probabilistic framework, based on the Hellinger distance, to quantify the difference between observed and simulated drought characteristics. Results show that many simulations have less than error in reproducing the observed drought summary statistics. The hypothesis that simulations and observations are described by the same distribution cannot be rejected for more than of the grids based on our distance framework. No single model stood out as demonstrating consistently better performance over large regions of the globe. The variance in drought statistics among the simulations is higher in the tropics compared to other latitudinal zones. Though the models capture the characteristics of dry spells well, there is considerable bias in low precipitation values. Good model performance in terms of SPI does not imply good performance in simulating low precipitation. Our study emphasizes the need to probabilistically evaluate climate model simulations in order to both pinpoint model weaknesses and identify a subset of best‐performing models that are useful for impact assessments.
The Changing Climate's Snowball Effect
Authors: Howley Korena
Published: September 2021

Shrinking snowpack, thawing permafrost, and shifting precipitation patterns have widespread consequences. Can new technologies—and public policies—help communities adapt?