bluuebunny/crossref_metadata_2025 huggingface dataset:
Pelatihan Video Broadcasting; Pengoperasian Kamera Video dan Aplikasi Live Streaming bagi Siswa SMK N 9 Surakarta
Authors: Muadz  , Riyanto Buddy
Published: October 2023

Mudahnya penyebaran informasi atau konten oleh publik terbuka secara lebar melalui media sosial. Beberapa media sosial mempunyai fitur video live streaming untuk berinteraksi dengan followers, menarik viewers, atau untuk kepentingan bisnis. Video live streaming sangat dinikmati oleh kalangan anak muda, tak terkecuali kalangan anak sekolah. SMK N 9 Surakarta mempunyai jurusan multimedia, dimana tujuan kompetensinya adalah untuk membekali siswa untuk terampil dan kompeten bidang multimedia. Video broadcasting adalah salah satu materi yang dipelajari di sekolah tersebut. Permasalahan tempat/lokasi pengabdian adalah masih terbatasnya peralatan yang memadai untuk mendukung untuk kegiatan praktek produksi live streaming di sekolah tersebut. Program Studi Ilmu Komunikasi UNISRI mempunyai pengalaman dan peralatan yang memadai dalam kegiatan belajar mengajar bidang keahlian broadcasting. Tim pengabdi melakukan kegiatan pengabdian kepada masyarakat kepada siswa SMK N 9 Surakarta jurusan multimedia dengan tujuan agar siswa mendapat pemahaman dan pengalaman lebih dari yang sudah diberikan di bangku sekolah. Metode yang digunakan dalam kegiatan pengabdian ini adalah; survei ke lokasi pengabdian, pelaksanaan kegiatan pelatihan, dan evaluasi kegiatan pelatihan. Peserta dalam kegiatan pengabdian ini adalah 30 siswa SMK N 9 Surakarta jurusan multimedia. Kegiatan pelatihan ini dilaksanakan selama dalam dua kali pertemuan. Pertemuan pertama pemberian materi serta praktek dan pertemuan kedua adalah praktek pengoperasian kamera dan aplikasi live streaming dalam sebuah acara yang disiarkan secara langsung melalui media sosial YouTube. Hasil dari kegiatan ini adalah, siswa SMK N 9 Surakarta, mendapatkan pengalaman dan pengetahuan baru dalam bidang video broadcasting.
Optimalisasi Pemanfaatan Media Sosial sebagai Alat Promosi Sekolah dalam Penerimaan Peserta Didik Baru
Authors: Wijayanto Pikir Wisnu , Qana’a Mutia
Published: October 2023

Pemanfaatan media sosial sebagai promosi sekolah sangat penting untuk menjangkau khalayak yang lebih luas, terutama dalam penerimaan peserta didik baru (PPDB). Namun, pemanfaatan teknologi belum optimal karena kurangnya sumber daya guru dan pegawai yang bisa menjadi pengelola media sosial. Sekolah masih mengandalkan metode promosi tradisional seperti membagikan brosur di sekitar rumah dan sekolah. Siapa yang belum mencapai target PPDB? Tim PKM dari Prodi D3 Sistem Informasi Telkom University membantu dengan memberikan pelatihan di SMK Plus Al-Aitaam Bandung pada tanggal 12 Juni 2023. Pelatihan ini diikuti oleh 20 peserta siswa dan guru, dibantu oleh dua orang dosen dan sembilan siswa. Materi pelatihan ini meliputi optimalisasi media sosial, games, dan role playing. Hasil pelatihan menunjukkan bahwa seluruh peserta menilai optimalisasi dan promosi media sosial untuk menjawab kebutuhan mereka dan membantu sekolah menyebarluaskan profil dan prestasi sekolah, menjaring calon siswa baru, dan mencapai target PPDB SMK Plus Al-Aitaam Bandung.
NANOTECNOLOGIA: REVISÃO INTEGRATIVA SOBRE USO DE NANOEMULGÉIS EM COSMECÊUTICOS
Authors: Vilas Boas de Almeida Beatriz , Gomes dos Santos Márcio , Tescarollo Iara Lucia
Published: October 2023

Com o avanço tecnológico nos dias atuais e o desejo da aparência perfeita, as buscas por tecnologias que podem favorecer a qualidade e os resultados obtidos por produtos cosméticos, no mercado da estética e beleza, vem crescendo cada vez mais. A nanotecnologia é uma área da ciência responsável pelos estudos e produção de sistemas estruturados em escalas nanométricas. Em sua forma nano, materiais tendem a mudar suas propriedades e dessa forma, é possível a criação ou aperfeiçoamento de determinados produtos, dentre eles os cosméticos, reunindo benefícios como controle de liberação, maior permeação cutânea, estabilidade e direcionamento de moléculas para o local de ação. Esse trabalho consiste em uma revisão integrativa sobre inovações nanotecnológicas aplicadas em cosmecêuticos, focando no potencial uso de nanoemulgéis para produtos destinados à pele, seus métodos de preparo, caracterização, desafios de formulação, usos, vantagens e possíveis riscos. Foi realizado um levantamento de dados em bases eletrônicas, considerando os critérios de inclusão, exclusão e seleção de artigos para discussão. Os trabalhos selecionados relatam aspectos promissores sobre o uso tópico de nanoemulgéis, mas, também evidenciam questões importantes e que requerem maior atenção, como a necessidade de regulação do setor, ampliação dos estudos de segurança, qualidade e eficácia.
POPULAÇÃO DE PROTEOGLICANOS EM DIFERENTES SÍTIOS ANATÔMICOS DA CARTILAGEM ARTICULAR DO JOELHO BOVINO
Authors: Esquisatto Marcelo Augusto Marretto , Erbert Contriciani Renata , Rosa Pimentel Edson , Gomes Laurecir
Published: October 2023

As forças mecânicas que atuam sobre uma articulação sinovial induzem alterações na composição e organização da cartilagem articular. Os condrócitos respondem a estímulos tanto de maneira quantitativa quanto qualitativa em relação à matriz extracelular. No presente estudo, foram investigados cinco regiões diferentes da articulação do joelho bovino em termos de populações de proteoglicanos e seu conteúdo de glicosaminoglicanos. A população de PG de alta densidade foi isolada por ultracentrifugação (fração D1) e filtração em gel. O PG apresentou tamanho semelhante em todas as regiões, porém na tíbia essas moléculas apresentam maior Mr. O sulfato de condroitina foi o glicosaminoglicano mais proeminente detectado na fração D1 e suas cadeias apresentaram em torno de 40 KDa. Duas populações de PG não agregantes foram isoladas em quantidade similar de todas as regiões. Essas moléculas apresentaram características polidispersas e migrando em torno de 70 e 200 kDa e exibindo um comportamento semelhante ao dos pequenos proteoglicanos decorin e biglican. A presença de decorin foi confirmada por immunoblotting. A análise do gel de agarose após a digestão com papaína mostrou a presença de dermatan sulfato nesses PGs. A presença de decorin e especialmente de biglican na fração D2 sugere que esses pequenos proteoglicanos podem interagir fortemente com proteoglicanos não agregantes de alto peso molecular. O imunoblotting para fibromodulina foi positivo para essas moléculas. Nenhuma diferença foi verificada em relação aos aspectos quantitativos, mas o tratamento com anti-fibromodulina também foi positivo para moléculas com 150 kDa. Essas moléculas desaparecem quando a amostra é tratada com agentes redutores. Esse fenômeno pode estar relacionado a autoagregação. A presença de FM agregado de 150 kDa foi mais proeminente na cartilagem articular da tíbia. Esses resultados indicam o efeito da estimulação mecânica nas diferentes regiões de uma mesma articulação. Ao considerar a relação existente entre a composição da matriz e estímulos mecânicos ou químicos, deve-se ter em mente que os condrócitos são sensíveis a diferentes estímulos e podem apresentar um comportamento metabólico heterogêneo em diferentes regiões de uma mesma articulação.
Assessment and Visualization of the Physician Role in the Opioid Crisis in New Hampshire Utilizing Geographic Information Systems
Authors:   University Of New England College Of Osteopathic Medicine, M Kusakavitch
Published: October 2023

This project utilizes GIS to map data pertaining to the physician role in combating this epidemic. There is a positive correlation between the number of opioid prescribers per county and the number of opioid prescriptions
A Randomized Sexual Health Intervention for Women in Treatment for Opioid Use Disorder: Sex And Female Empowerment (SAFE) Increases Reproductive Knowledge and Contraceptive Self-Efficacy
Authors:   University Of North Carolina At Chapel Hill, E Johnson
Published: October 2023

Objectives: Women with Opioid Use Disorder (OUD) commonly report unintended pregnancies. Clinics providing Medication for OUD (MOUD) treatment serve as ideal sexual health education settings.
Comprehensive Strategies for Addressing the Opioid Epidemic: A Review of Overdose Education, Naloxone Distribution, and Suboxone Interventions
Authors:   University Of North Texas Health Science Center, Judd Dallin
Published: October 2023

The United States is currently grappling with an opioid epidemic, prompting the development of Opioid Overdose Education and Naloxone Distribution programs (OEND) and Suboxone distribution programs as a response in certain states.
Integrating the Complementary Therapies of Energy Psychology and Dreamwork – the Dream to Freedom Method – a Review
Authors:   International Association For The Study Of Dreams, Hoss Robert J
Published: October 2023

The full case material and protocol described herein is available in Dream to Freedom: A Handbook for Integrating Dream work and Energy Psychology.
Treating Monocular Diplopia with Acupuncture: A Case Report
Authors:   Hospital Of Sichuan Integrative Medicine Hospital, Zhang Jicheng
Published: October 2023

For example, hypertension leads to cerebrovascular sclerosis and peripheral artery nerve compression, resulting in extraocular muscle paralysis in patients, and then diplopia appears.
Biosyndromes of Human Deification, of Illegitimacy, and the Myth of the Hero
Authors:   Centro De Prevención Y Tratamiento De La Violencia Sexual E Intrafamiliar, Cuevas-Sosa Alejandro
Published: October 2023

In the biodialogue that we establish through any relaxation validated technique, the bioimage of a BEG would be a living and acting virtual biointerfaceme, just like the rest of bioimages that are formed during it or in dreams.
Twenty Years of Non-Invasive Vascular Evaluation: from Bench to Bedside from Theoretical to Precision Medicine
Authors: Forcada Pedro
Published: October 2023

To analyze, from a historical point of view, the scientific and technologic progression of the non-invasive vascular evaluation, in particular the huge step ahead in the last 20 years, in parallel with the evolution from a “treatment-after- event” based Medicine to Preventive Medicine. No-invasive vascular Evaluation jumped in the last twenty years from the bench to the bedside, giving rise to a Precision Medicine, detecting and preventing the atherosclerotic disease in the earliest stages, in order to control the huge burden of cardiovascular disease that the human kind has been suffering the last hundred years. A worldwide and widespread use of non-invasive vascular evaluation in the current clinical practice for cardiovascular prevention remains as a challenge, and this review is a call to action to do so.
Forschung in der Personzentrierten und Experienziellen Psychotherapie 2008–2019
Authors: Käfer-Schmid Gerald , Kurl Neena , Keil Sylvia , Korunka Christian , Topaloglou Helena M.
Published: October 2023

File, Hutterer, Keil, Korunka und Macke-Bruck beschäftigten sich in einem 2008 veröffentlichten Artikel vorrangig mit publizierten Wirksamkeitsstudien über Klienten-/Personzentrierte und Experienzielle Psychotherapien aus den Jahren 1991 bis 2008. Aktuell wurde systematisch der Frage nachgegangen, welche Entwicklungen es in den elf Folgejahren gegeben hat. 343 in facheinschlägigen Zeitschriften publizierte Forschungsarbeiten wurden ausgewertet. Der erste narrative Review setzte sich mit der Forschung von am personzentrierten Ansatz orientierten Psychotherapien breiter auseinander. Dieser zweite Teil befasst sich mit der Ausbildungsforschung, den Störungsbildern in der personzentrierten Forschung und mit dem Bereich der Kinder-, Spiel- und Jugendlichenpsychotherapie.
Verwickeltes ent-wickeln und weiter-entwickeln
Authors: Brossi Rosina , Lottaz Angelo
Published: October 2023

Ausgehend von der alltäglichen Erfahrung als Psychotherapeut*in, dass die Rogerschen Konzepte dank ihrem hohen Abstraktions-grad einerseits einen grossen Freiraum und einen kohärenten Reflexions- und Orientierungsrahmen bieten, andererseits aber ihre Abstraktheit die Gefahr birgt, dass Haltung und Handlung vermischt und die Therapeutenpersonen in der ganz konkreten thera-peutischen Situation allein gelassen werden, treten die Autorin und der Autor in einen Dialog. Ihrer Meinung nach hat diese Schwierigkeit mit einem Stopp im Konzeptbildungsprozess des PZA zu tun, den sie historisch im Wisconsin-Projekt verorten. Die damaligen Auseinandersetzungen haben dazu geführt, dass das Experiencing Konzept von Eugene Gendlin, das eine Handhabe für die konkrete Situation bieten könnte, nie wirklich in die PZA-Konzepte eingeflossen ist.
Aktivitas Antimikroba Ekstrak Daun Karamunting (Melastoma malabathricum L.) Terhadap Bakteri Penyebab Diare
Authors: Tandirogang Nataniel , Paramita Swandari , Yasir Yadi , Yuniati Yuniati , Aminyoto Meiliati , Fitriany Evi
Published: October 2023

Diare hingga kini masih merupakan masalah kesehatan utama di Indonesia. Pemberian antibiotik merupakan salah satu upaya penatalaksanaan diare, namun belakangan terkendala masalah adanya resistensi terhadap antibiotik. Berdasarkan hal tersebut, maka upaya pencarian sumber antimikroba baru berbasis tumbuhan obat perlu dilakukan. Penelitian ini dilakukan untuk menguji potensi ekstrak daun karamunting (Melastoma malabathricum L.) yang secara tradisional digunakan etnis Dayak sebagai obat diare. Aktivitas antimikroba ekstrak tumbuhan diuji terhadap 5 bakteri standar;  Escherichia  coli ATCC 35128, Shigella sonnei ATCC 25931, Campylobacter jejuni ATCC 33291, Pseudomonas aeruginosa ATCC 15442, dan Enterobacter cloacae ATCC13047. Pengukuran aktivitas antimikroba dilakukan dengan disc diffusion method (Kirby-Bauer) dan pengukuran minimum inhibitory concentration (MIC). Hasil penelitian menunjukkan ekstrak daun M. malabathricum dapat menghambat pertumbuhan seluruh bakteri uji, dengan diameter zona hambat sebesar 12,3-16 mm dan MIC sebesar 2,3-13,3 mg/ml. Kesimpulan penelitian ini adalah ekstrak daun M. malabathricum berpotensi sebagai antidiare berdasarkan aktivitas antimikrobanya.
Uji Teratogenik Air Rebusan Mie Instan Selama Masa Kehamilan Mencit Betina (Mus musculus L.) Melalui Pengamatan Kelainan Morfologi Fetus
Authors: Sianturi Sister , Muti Annisa Farida , Perdana Moh. Benny
Published: October 2023

Indonesia is one of the second ranked countries in the world consuming the most instant noodles. This product is liked by all people, especially pregnant women, so research is needed to determine the effect of consumption of instant noodles on fetal development. This study uses mice as a test animal. The purpose of this study was to determine the teratogenic effects of instant noodle cooking water on pregnant mice (Mus musculus L.) concentrations of 30%, 50%, and 70% based on morphological observations of fetal mice during pregnancy. This research is experimental with a completely randomized design (CRD) method using 60 experimental female mice in pregnancy divided into 10 groups, 1 group was given aquadest as a control group and 9 groups were given instant noodle cooking water in 3 different brands with a concentration of 30% , 50%, and 70% given on the 6th day of pregnancy until the 15th day of pregnancy. Then on the 18th day female mice were sacrificed by dislocation of the neck to see the teratogenic effects based on morphology in the fetus. The results of the statistical test showed that there were differences in the average number of dead fetuses in each group (p = 0.05), differences in body weight (p = 0.0001), and body length (p = 0.0001) and found one fetuses that experience cleftpalate or abnormalities in the palate of the fetus of mice in the treatment of instant noodle boiled water concentration of 70%
Molecular Docking Study of Nigella sativa Alkaloid Compounds as the Inhibitor of Papain-Like Protease SARS-CoV-2
Authors: Gholam Gusnia Meilin , Firdausy Iman Akhyar
Published: October 2023

SARS-CoV-2 causes about 66% of China’s Wuhan market workers to experience fever, dry cough, and fatigue. Black cumin (Nigella sativa) is a plant with many benefits to cure many illnesses like hypertension, headache, infection, and inflammation. This study aimed to investigate the inhibition by compounds belonging to the Alkaloid group from Black Cumin Seed to inhibit PLpro activity as a target for SARS-CoV-2. The study used five alkaloid compounds ((2E,4E)-Decadienal, (2E,4Z)-Decadienal, Nigellicine, Nigellidine, and Nigellimine) from the Black cumin seed and a PLpro SARS-CoV-2 receptor (PDB ID: 6WX4). The methods used are ligand and receptor preparation, grid box validation, molecular docking, 2D and 3D visualisation, and data analysis using Gibbs free energy, type of interaction, and contact of amino acid residues data. This study used YASARA structure and BIOVIA Discovery Studio. The results showed that Nigellidine has the highest Gibbs free energy with a -2.67 kcal/mol score, higher than VIR251. PLpro has a catalytic triad at Cys111, His272, and Asp286 residues, the compound that binds to the active site is Nigellicine found at amino acid Cys111 with Pi-Sulfur.
Molecular Docking and Molecular Dynamics Simulation using Monascus sp. as a Candidate Cervical Cancer Drug
Authors: Yuliana Anna , Rahmiyani Ira , Kartika Cindi
Published: October 2023

Cervical cancer is the fourth most common female cancer worldwide and results in over 300000 deaths globally. Given that HPV prophylactic vaccines do not exert a therapeutic effect in individuals previously infected, it is unlikely that HPV-associated cancers will be eradicated in the coming years. Therefore, there is an emerging need for the development of anti-HPV drugs. The purpose of this study is to find out Monascus sp. as cervical anticancer using molecular docking and dynamics methods. The results of docked with AutodockTools were visualized with Pymol, analyzed the effectiveness using the Ramachandran plot. The docking results show that there are 2 pigments that have lower G than raloxifen in estrogen receptor beta with the lowest G indicated by the pigment Monascin and Ankaflavin, which is -6.94 kcal/mol with Ki value of 39.49 nM and -6.22 kcal/mol with Ki value of 27.78 nM. The results of molecular dynamics, Ankaflavin and Monascin have good stability at estrogen receptor beta because the outlier area has a value 11.722% and 10.256%. And the amino acid residues in the most preferred area were 68.864% and 70.330%. In addition, Monascopyridine B and Monascuspiloin pigments showed good and stable results at the EGFR receptor because the outlier areas were 14.692% and 10.623%. And the amino acid residues in the most-favored region were 65.403% and 73.260%. Based on the results of this study, we predict that Ankaflavin, Monascin, Monascopyridine B and Monascuspiloin can be used as new cervical anticancer candidates after validated with in vitro and in vivo tests.
Evaluation of Serum Chemerin Level in Diabetic, Hemodialized Patients
Authors: M. Hussain Al-Obaidi Saad , H. Ahmed Al-Obaidi Amina , S. Ahmed Salam
Published: October 2023

Background: Diabetic nephropathy (DN) also called diabetic kidney disease (DKD) is one of the maincomplications of diabetes mellitus (DM) and it is the most common cause of end-stage renal disease(ESRD). Diabetes mellitus has been proved as conventional risk factors for the development of coronaryartery diseases (CAD). Adipose tissue is now considered as an active endocrine gland secretes severalinflammatory cytokines, namely, adipokines or adipocytokines such as chemerin, visfatin, leptin andothers, which interfere with insulin sensitivity, with glucose and lipid metabolism, and with theinflammatory process. Aim: The aim of this study was to evaluate serum chemerin level and otherbiochemical parameters in in diabetic hemodialized patients to determine the risk of cardiovasculardiseases (CVD) in DKD. Materials and methods: This case control study was conducted on a samplecomposed of 50 patients with diabetic nephropathy and a control group consists of 50 apparently normalhealthy subjects. Estimation of serum chemerin level by ELIZA, lipid profile, Blood urea, serumcreatinine, serum albumin, serum electrolytes, serum uric acid and serum malondialdehyde (MDA) weredone for both patients and control. Body mass index (BMI) and glomerular filtration rate (GFR) werecalculated for both patients and control. Atherogenic index of plasma (AIP) and coronary artery diseaserisk percentage (CAD risk %) were also calculated for both patients and control group. Results: Theresults of this study showed that the level of serum chemerin was significantly higher in DN patientscompared to control.Serum chemerin level was correlated with other parameters.
The Relation between Some Hormonal And Biochemical Parameters In Infertile Women
Authors: A. Tayes Amna , M. Rahim Saleh , M. Yaseen Enas
Published: October 2023

Infertility is the most gynecological problem which is increasing all over the world.Many studies were done and many theories were tried to put the pathophysiology andcauses of infertility in order to find solutions to this problem. The aim of this study is:-1. To study the distribution of the problem all over Tikrit governorate.2. To study the relation between some hormones, biochemical parameters and infertility.Patients and Methods: 600 infertile patients were enrolled .The study conducted atobstetrics and gynecology out-patient of Tikrit Teaching Hospital. The primaryinvestigations of infertility were done to all women. Seventy two patients complained ofovarian cause infertility were taken randomly as a group -1- and 18 normal fertilewomen as a control group or group -2- to study FSH, LH, prolactin, insulin, leptin, TSH,T3, T4, blood sugar, lipid profile, BMI ,Glutathione (internal anti-oxidant) andMalondialdehyde ( oxidative stress product). Results: infertility increased in Iraq after2003 war. The primary infertility is more than secondary infertility. Many factorsassociated with it such as: age, BMI, blood groups, blood sugar, lipids profile andhormones. Different relations between study’s hormones, Glutathione andMalondialdehyde. Conclusion: The environmental factors can participates in infertilitysince 2003 in Iraq. Different hormones such as FSH,LH,Prolactin,Insulin, TSH, T4, T3,Leptin and others play a role in pathogenesis and different mechanisms of infertility.These hormones and infertility at the end result would be affected by oxidative stress ofthe body.
Comparison of Different Medical Treatment of Missed Abortion
Authors: Hashim Abid Alkareem Israa , Jasim Athraa
Published: October 2023

Missed abortion constitutes a significant problem in gynecology patient, as itrepresents an unfortunate outcome of early pregnancy. Despites its frequencyhowever, there is still scope for improvement in patient care as it remains responsiblefor considerable emotional and psychological trauma to the patients. Aim of TheStudy:- This study is designed to evaluate for using misoprostol therapy in compareto other medical therapy for Iraqi female. Patients and Method:- The current studyrepresent a prospective clinical trial that was done on patients with missed abortion.The total number of cases that involving in the study were included 104 cases & 52 ofthem use mifepristone in a standard regimen and 52 use misoprostol in standardregimen, and those who failed to response from the two groups were selected to use acombination of these two drugs. Of these drugs misoprostol alone regimen was shownto be the most effective method for inducing complete abortion in 77.8% of thepatient using this drug alone within a shorter duration (<12 hours), and equal rate ofcomplication with other groups while mifepristone shows (55%) rate of completeabortion while the rate for combination of drugs was (43.6%). Other factors such asthe gestational age of the patient, types of delivery, Parity and the patient age werenot show to be significantly correlated with the end results. Conclusion:- The currentstudy found a significant correlation between the duration from the last delivery andthe end result, that complete miscarriage occurs more in patient delivered since morethan 11 months.
STRATEGIZING FOREIGN ECONOMIC ACTIVITY IN THE CONTEXT OF ENTERING FOREIGN MARKETS
Authors:   Zhytomyr Polytechnic State University, Yankovoi Roman , Kulish Damir ,   Zaporizhzhya National University, Yashechen Inna ,   Kyiv national university of culture and arts
Published: October 2023

The article substantiates the strategy of foreign economic activity in the context of entering foreign markets. As a result, we applied a statistical regression to predict the relationship between dependent and independent variables, the main purpose of which is to predict the probability of proposed factors (firm size, International Experience, Innovation, Network, Product Characteristics, assets, export intensity, and industry) affecting the level of resource utilization obligations in firms ' choice of entry modeThe article also explains that the size of SMEs strongly and positively affects the extent to which firms participate in the choice of entry method.International experience also has a significant impact on firms ' decisions regarding participation in certain ways of entering the market. As expected, network relationships significantly influence the choice of ways to enter the foreign market. The intensity of assets and exports is indicated as positive and very important. Empirical results show that innovations not only significantly influence the firm's choice of a way to enter the foreign market, but also correspond to the forecast direction.Also, the product characteristic factor has a strong positive effect. In addition, firms that engage in higher levels of advertising are more likely to choose high-level resource commitments, such as joint ventures or direct investment. The high level of export intensity also encourages firms to choose high-level resource commitments. The industry also positively correlates with the probability of choosing high-level resources in the selected mode of entering the foreign market.
PROFESSIONAL DEFICITS OF ADAPTIVE SCHOOL TEACHERS IN THE PROCESS OF INTERACTION WITH THE FAMILY
Authors:   Omsk State Pedagogical University, Omsk, Russia, Kruglova E.E.
Published: October 2023

New socio-cultural and socio-economic factors affect the style and way of life of families. Currently, special interaction of educational organizations with families raising a child with disabilities is required. The modern family makes a number of demands, requests to the state, educational, public organizations and, in particular, teachers working with their children. The state is taking a number of measures to improve the professional and personal qualities of a teacher. The study of professional deficits of modern teachers of an adaptive school, the identification of general and specific problems encountered in the process of testing modern technologies for interaction with a family raising a child with disabilities will help to find and systematize effective ways to solve the professional problems of a teacher of an adaptive school in the future. Equipping the material and technical base is reflected in the implementation of the national projects “Success of every child”, “Modern school”, “Support for families raising a child with disabilities”, which allow adaptive schools to acquire innovative teaching aids, improve the conditions of the educational space. The development of a specialized methodological base is aimed at creating specialized programs in accordance with the individual capabilities of the child and his family. One of the promising ways to develop methodological work is the organization of network forms of interaction between teachers. The creation of conditions for accessible education includes the presence of narrow specialists in adaptive schools: a psychologist, defectologist, speech therapist, social pedagogue, etc. The development of individual teacher development routes based on the identified difficulties will help to effectively work to overcome professional deficits. This route should include a number of modern technologies to expand the knowledge of the teacher in the psychological, pedagogical, medical, social and legal spheres.
FORMATION OF UNIVERSAL COMPETENCIES AMONG STUDENTS THROUGH THE IMPLEMENTATION OF THE “BEST ASSET” PROGRAM
Authors:   Orenburg state pedagogical university, Orenburg, Russia, Flyantsraih A.P.
Published: October 2023

In the context of changing trends in the development of Russian society, the information war for the “minds” of young people, the problem of education and prevention plays an important role at the state level. The recent tragic events in our country associated with the manifestations of “schoolshutting” and “collumbine” prove the relevance of the problem of preventive education of young people. Today, such pedagogical categories as “education” and “prevention” should be considered in a single interconnected university environment, due to the increase in negative manifestations among young people. We believe that the mission of the university today is the formation of a safe educational and preventive environment, which will be aimed not only at the safety of students, but also at comprehensive, harmonious and professional development. For the organization of this environment, we offer a special pedagogical impact — the “Best Asset” program, which contributes to the formation of this environment and is a kind of tool for the assimilation of universal competencies among students. Since modern education in Russia is built on a competence-based approach, the essence of which is to acquire the necessary key competencies that satisfy the labor market. We believe that the “Best Asset” program as a means of organizing the educational and preventive environment of the university should meet modern realities and form universal competencies among students, which are so necessary for employers. The article discusses the formation of universal competencies among students through the implementation of the “Best Asset” program at the university.
GOVERNMENT REFORM OF HIGHER EDUCATION IN MODERN CHINA
Authors:   Orenburg state university, Orenburg, Russia, Vaskina M.V.
Published: October 2023

Currently, the developed countries of the world are striving to increase their competitiveness on the world stage through the training of new qualified personnel to ensure rapid economic growth and a high standard of living. Now the competent construction and timely reform of the country’s education system is almost the main component for the successful development of the state. Chinese higher education is being popularized around the world. The Chinese university has risen to the same level of education as the universities of England and Germany. China has achieved unprecedented heights in the reform of higher education, which has led to an improvement in the image of Chinese education on the world stage. This growth is due to a competent state program for the transformation of higher education, which originates from the 80s of the 20th century to the present, and is implemented through effective reforms, laws and projects. The study analyzed the features of state support for higher education in China, as well as its structure. Based on the analysis, the statistics of the increase in the number of universities in the country and students in them is presented. The differences between public and private higher education in the “Celestial Empire” are considered. A model of state support for graduates to create a business on their own and to support entrepreneurship when hiring a young qualified workforce is described. The percentage of employed graduates of Chinese universities and the problems faced by the graduate in employment, and the employer when hiring a young specialist are considered.
ON UNIFICATION OF MULTIPLE, CURVILINEAR AND SURFACE INTEGRALS PRESENTATION IN ENGINEERING DIRECTIONS OF UNDERGRADUATE STUDIES
Authors:   Orenburg State University, Orenburg, Russia, Gerasimenko S.A. , Pavlenko A.N. ,   Orenburg State University, Orenburg, Russia
Published: October 2023

In modern world, the up-to-date trends in reforming of higher education lead to a significant reduction of classroom activities in the educational process, which extremely negatively affects the study of disciplines of the mathematical cycle due to their abstractness and often complexity of material presentation. Thus, there is a necessity to increase the efficiency of contact work and to widen the role of unsupervised work of students. This problem is especially evident in the study of the topic “Integral calculus for functions of several variables” in the engineering directions of undergraduate studies. One of the factors that contribute to increasing the efficiency of contact and unsupervised work is the unification of the educational material presentation related to this topic. In this article, we suggest a new approach to the study of multiple, curvilinear and surface integrals in the engineering directions of undergraduate studies, which include a unified parallel consideration of these integrals when using: 1) a preliminary revision of the topic “Defined integral” and the study of new material on this basis, 2) interdisciplinary connections, 3) information technologies. It is advisable to use appropriate methodical support to improve the effectiveness of this approach. As the latter, it is appropriate to use tutorials, problem books and individual tasks, posters and 3d models, interactive guidelines integrated with applications, written in high-level languages, generators of typical tasks, etc.
FEATURES OF ONLINE COMMUNICATION IN THE SYSTEM OF HIGHER EDUCATION: ETHICAL ASPECTS
Authors:   Orenburg State Medical University, Orenburg, Russia, Fomina M.V. , Maslovskaya S.V. ,   Regional Center for the Development of Education, Orenburg, Russia, Mikhailova E.A. ,   Orenburg State Medical University, Orenburg, Russia
Published: October 2023

The debatability of the problem of ethics of media communication of the academic community, in the framework of the implementation of the distance format of online learning, is beyond doubt. In the course of the study, the vast majority (95.7 %) of respondents agree with the need to comply with ethical standards when using a remote format of communication. When asked if there are differences in the ethics of online and offline communication, 59.6 % of respondents answered that communication in networks has its own characteristics, which distinguishes it from communication in the external, “textured” world, 29.7 % did not find any differences and 10.7 % could not unambiguously answer the question. Of particular interest are the problems of corporate ethics of network communities. Studies have shown that 8 (8.5 %) respondents do not exclude anonymous communication on the network and 65.9 % of respondents published information under an assumed name. Along with this, 65 (69.1 %) respondents are aware of the legal responsibility in the virtual space, which indicates the Internet literacy of active users. It is known that the ethics of communication involves respect for the rights of other people. The study showed that the majority — 84 respondents (89.4 %) were in favor of respecting copyright, but only 50 (53.2 %) support privacy. The extremely negative aspects of remote communication should not be overlooked. As the survey showed, 32 (34.0 %) respondents encountered obscene language and obscene content on the network, as well as insults and slander against themselves (in 15.9 % and 17.0% of cases, respectively). Thus, the information environment is increasingly turning into a complex of objectively acting factors that determine the moral and ethical development of the individual.
DEVELOPMENT OF A COMPETENT MODEL OF REQUIREMENTS FOR THE RESULTS OF TRAINING SPECIALISTS IN THE FIELD OF COMPUTER GRAPHICS AND GAME SPECIAL EFFECTS
Authors:   Nosov Magnitogorsk State Technical University, Magnitogorsk, Russia, Savva L.I. , Novikova T.B. ,   Nosov Magnitogorsk State Technical University, Magnitogorsk, Russia, Kurzaeva L.V. ,   Nosov Magnitogorsk State Technical University, Magnitogorsk, Russia, Dubrovskiy V.V. ,   Nosov Magnitogorsk State Technical University, Magnitogorsk, Russia
Published: October 2023

Today, the industry of computer graphics and game special effects and its application in the development of computer games, virtual/augmented reality (Ar / Vr) occupies a leading position in all areas of life. The training of specialists for the computer graphics and animation industry is very important. However, today, in higher educational institutions there are no disciplines that consider the knowledge and skills of working with computer graphics and special effects for game development and Ar / Vr. The computer games industry is mainly self-taught, who study independently in certain areas of graphics from separate courses. There is no complete course in computer graphics for the computer games industry, Ar/Vr. We have decided to develop an electronic course on the discipline “Fundamentals of creating computer graphics and game special effects for the industry of computer games and virtual/augmented reality”. We have presented in detail the description of the development of a computer model of requirements for the results of training of specialists in the field of computer graphics and game special effects in the gaming industry. After analyzing the theory, a list of professions of people who are employed in the industry was described and their functionality was highlighted. Based on previously identified professions, using international standards, the requirements for the competencies of IT specialists in the field of computer games, computer graphics and animation have been formed. From the identified competencies, a competency-based model of requirements for learning outcomes in the subject areas of the computer graphics and animation industry in the computer games industry was synthesized.
ADVANCED PRACTICES IN THE INTERACTION OF A REGIONAL UNIVERSITY AND A TECHNOLOGICAL INNOVATOR ENTERPRISE
Authors:   Kumertau Branch of Orenburg State University, Kumertau, Russia, Sazonova T.V.
Published: October 2023

In the current socio-economic situation, the organization of advanced practical training of students is required, which ensures the formation of import substitution competencies and intensive technological development of the region. Opportunities for the development of new and promising production technologies can be created through the interaction of a regional university and innovation-oriented enterprises. To date, resources, organizational and pedagogical conditions and experience of multifunctional cooperation of a regional university with innovation-oriented enterprises for the purpose of advanced practice have not been sufficiently disclosed. There are well-known studies of a cluster of enterprises — technological innovators who need continuous improvement of personnel and are interested in partnership with vocational education. In turn, the regional university needs production resources to organize advanced professional training. The methodology of the integrative approach determines the logic and principle of the joint activities of the stakeholders of advanced training. Interested partners create joint structural units that unite on the basis of the university the production resources of the innovator enterprise, the development and transfer of technologies and scientific results of partners, the competence of the teaching staff of the university and the needs of advanced training of regional customers-employers. The activities of the Advanced Professional Training Center established in the Kumertu branch of the OSU revealed characteristic variants of such structural units: the TechnoNIKOL resource center and the KNAUF consulting center. Network interaction of stakeholders is implemented within the framework of contractual “co-resource” relations in the following areas: methodological, resource, reputational, career guidance, educational, consulting, expert, personnel, marketing, commercial, research, scientific, industrial, entrepreneurial, recruiting. Tripartite agreements “university-student-enterprise” are concluded, guaranteeing employment according to the acquired promising competencies. The leading nature of the practices is determined by taking into account the forecast of the development of the socio-economic, personnel, educational situation in the presentation of the products and services of the innovator to regional customers-employers, as well as the ecosystem development of the regional university with the optimal use of partners’ resources.
Early evidence for inclusion of practice of morning ingestion of water as a lifestyle modification (adjuvant) in management of hypertension in patients of diabetes mellitus
Authors: Rathod Chirag , Sheth Anavi , Tailor Poorva , Rana Himanshu , Godbole Varsha , Shah Ashka
Published: October 2023

Objectives:

Researches reflecting the role of water in blood pressure (BP) regulation are documented to a lesser degree. A holistic approach, combining standard treatment protocols with lifestyle modifications, serves as the best approach to check the increasing prevalence and coexistence of hypertension (HTN) and diabetes mellitus. Thus, we aim to access the effects of morning ingestion of water on HTN in diabetic individuals when practiced adjuvant with antihypertensive and oral hypoglycemic medications.

Materials and Methods:

We conducted a prospective cohort with 68 patients having diabetes mellitus and HTN, with 34 participants each in the study and control group. The control group followed standard treatment protocol for HTN and diabetes mellitus. Study group in adjuvant to above practiced drinking 0.75–1 L of water altogether (within 5–10 min) in the morning immediately after waking up in a sitting (crossed leg or squatting) position. The changes in BP and other biochemical parameters were recorded.

Results:

For the study group (n = 34), repeated measured analysis of variance revealed a statistically significant lowering of systolic BP (SBP): F (2, 66) = 17.17, P ≤ 0.0001 and diastolic BP (DBP): F (2, 66) = 7.31, P = 0.0014. Moreover, post hoc analysis with Tukey–Kramer multiple comparisons found that the mean difference was statistically significant for baseline and end of 2 months – SBP: (14 [95% confidence interval, CI 8.23–19.77] mmHg, P < 0.001) and DBP: (6.35 (95% CI 2.22–10.48) mmHg, P < 0.01). The SBP and DBP at baseline versus the end of 2 months were 143.76 (13.40) versus 129.76 (14.27) mmHg and 84.35 (12.01) versus 78 (8.90) mmHg, respectively. In the study group, regression in the stage of HTN was observed where ten of 15 patients and 11 of 19 patients recovered from Stage I and Stage II HTN, respectively. Furthermore, 67.6% of the study group achieved a target BP of <140/90 mmHg at the end of 2 months.

Conclusion:

The practice of morning ingestion of water does affect BP regulation and this practice can be a new potential lifestyle modification adjuvant with standard treatment guidelines for management of HTN in patients of diabetes mellitus.
Development and In silico ADMET Analysis of Novel Flavonoids Derivatives as Potent, Non-Competitive and Selective PTP1B Inhibitors
Authors: Faiad Eman , Alchab Faten
Published: October 2023

Diabetes mellitus is a serious disease that threatens human health. The most prevalent type of diabetes mellitus is type 2 (T2DM) which is characterized by the lack of insulin secretion and resistance to insulin in target tissues. Protein Tyrosine Phosphatase 1B (PTP1B) plays an important role in the dephosphorylation of phospho-tyrosine residues from the insulin receptor and its substrate. Studies have shown that overexpression of PTP1B protein and its increased activation have been associated with insulin resistance and thus it is a promising therapeutic target for type 2 diabetes. The discovery of selective and effective inhibitors on the active target site present a great challenge due to the site charge and the high degree of conserved active site. Therefore, the identified allosteric site of enzyme PTP1B was chosen to design and evaluate ligands based on effectiveness and selectivity, then filter the compounds based on their ADMET properties in silico to identify the potential inhibitors of the PTP1B enzyme. Among the designed molecules, 14 compounds were obtained with better affinity and selectivity for PTP1B. Some of these compounds showed acceptable pharmacokinetic properties of ADMET and were expected to be non-mutagenic. Thus, they can be considered as promising PTP1B inhibitors.
Photocatalytic Degradation of Eriochrome Black-T Dye by Immobilized Dowex-1x8
Authors: Yadav Lal Chand , Jaimini H. , Meena K. , Meena R.C. , Meena S.L.
Published: October 2023

Eriochrome Black-T (EBT) is a commonly used textile dye. It is a harmful organic molecule and is also present in textile effluent. The photocatalytic degradation has been studied using MBIR Dowex-1×8 as the photocatalyst. Some parameters such as pH, light intensity, the amount of photocatalyst and initial dye concentration were also studied. At room temperature at pH 7.5, the optimal degradation of Eriochrome Black-T dye (30 mg/L) was observed in about 210 minutes and the photo catalyst load was 2.0 gm. The kinetic study related to the photocatalytic degradation of EBT followed first order kinetics where the rate constant is 2.11x10-2 min-1. This catalyst can degrade dye molecules and can recover transparent water from coloured textile effluent in few hours of treatment.
Microbial mediated Synthesis and characterization of Ag Nanoparticles and its Synergistic impact on Actinobacterial, Anticancer and Antihelminthic activity
Authors: Manoharan Gomathi , Kumarasamy Suresh , Ranganathan Muthusamy
Published: October 2023

In this study, an endophytic actinomycetes strain of Streptomyces viridodiastaticus strain MGR23 was isolated from the roots of the medicinal plant Centella asiatica. The biosynthesized Ag-NPs were characterized using UV-Vis spectroscopy, Fourier transform infrared (FT-IR), Scanning electron microscopy (SEM), X-ray diffraction (XRD) and Zeta potential, which confirmed the successful formation of crystalline, spherical silver nanoparticles. Biosynthesized AgNPs significantly inhibited and reduced the growth of medically important survival microorganisms (Streptomyces viridodiastaticus MGR 23 against Streptomyces toxytricini D2, Acidothermus cellulolyticus CA16, Streptomyces sp. MGR 21, Aciditerrimonas ferrireducens SM7 and Streptomyces tritici D5). The biosynthesized Ag-NPs exhibited broad-spectrum antihelminthic activity. Our data elucidated that the biosynthesized Ag-NPs had a highly cytotoxic effect against the cancerous L6 cell line under in vitro conditions, revealing a maximum IC50 value of 1.0 μg/mL and no known anticancer drug was used as a positive regulation. AgNPs have a remarkable synergistic impact that points to their considerable potential in nanomedicine for future clinical use as a combination therapy.