bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of Hollow Fiber Liquid Phase Microextraction Method for Determination of Diazinon Residues in Vegetable Samples
Authors: Amanda Eviomitta R. , Raharjo Yanuardi , Handajani Usreg S.
Published: July 2022

An extraction method based on a combination of hollow fiber liquid-phase microextraction with high-performance liquid chromatography diode array detector (HF-LPME HPLC-DAD) has been developed and demonstrated to analyze pesticide residues in vegetables. This study aims to determine the optimum extraction conditions and validation performance of this method. Diazinon pesticide was selected as the target model analyte. HF-LPME is performed by stacking microliter organic solvent droplets through an HPLC syringe coated with polypropylene hollow fiber by directly dipping it into the sample solution and stirring it during the extraction process. Finally, the organic solvent was put into an HPLC syringe at the end of the extraction. Then, it was injected into the HPLC-DAD at the wavelength of 247 nm. Several important extraction parameters have been optimized. The optimization results showed the type of organic solvent of n-hexane, the length of the hollow fiber of 1.5 cm, the volume of the sample solution of 20 mL, and the stirring speed of 600 rpm. The validation performance obtained a limit of detection (LoD) of 0.10 mgL-1, limit of quantification (LoQ) of 0.33 mgL-1, percent recoveries of 99.88%, a coefficient of variation of 3% (n=15), and the enrichment factor of 19,982 times. Under optimal conditions, the developed method was applied to extract diazinon in vegetable matrix samples using the spiking method. Mustard green was selected as a model matrix sample. From the research, the percentage recoveries of diazinon obtained in the mustard green matrix sample are 98.80% - 100.41%.
Antioxidant Activity Test of Ethanol Extract of Ripe and Young Cocoa Pods (Theobroma Cacao L.)
Authors: Andriana Andriana , Jura Minarni R.
Published: July 2022

Antioxidant activity test of Ethanol Extract of Ripe and Young Cocoa Pod Skin (Theobroma Cacao L.) with DPPH (1,1-diphenyl-2-picrylhydrazyl) using UV-Vis spectrophotometer has been carried out. This study aimed to determine the IC50 value of the ethanol extract of ripe cocoa pods and young cocoa pods (Theobroma Cacao L.). The mature and young cocoa pods were extracted using absolute ethanol solvent and tested for their antioxidant activity using DPPH (1,1-diphenyl-2-picrylhydrazyl). The concentration variations used in the ethanol extract of ripe cocoa pods and young cocoa (Theobroma Cacao L.) were 20 ppm, 40 ppm, 60 ppm, and 80 ppm. The results showed that the IC50 values of the ethanol extract of ripe and young cocoa pods were 76.094 ppm and 91.884 ppm, respectively. Meanwhile, the IC50 value of vitamin C compared was 63.519 ppm. Based on the IC50 value data above, it can be seen that the antioxidant activity of the ethanol extract of young cocoa pods and ripe cocoa pods are potent antioxidants.
Development and validation of a full physiologically-based pharmacokinetic model for sublingual buprenorphine that accounts for nonlinear bioavailability
Authors: Hoogdalem Matthijs van , Johnson Trevor , Vinks Alexander , Mizuno Tomoyuki
Published: July 2022

Sublingual buprenorphine is used in the treatment of opioid use disorder
(OUD) and neonatal opioid withdrawal syndrome (NOWS). The aim of this
study was to develop a full physiologically-based pharmacokinetic (PBPK)
model that can adequately describe dose- and formulation-dependent
bioavailability of buprenorphine. Simcyp (v21.0) was used for
model construction. Linear regression modeling was explored to describe
sublingual absorption of buprenorphine across dose. Published clinical
trial data not used in model development were used for validation. The
PBPK model’s predictive performance was deemed adequate if the geometric
means of ratios between predicted and observed (P/O ratios) area under
the curve (AUC), apparent clearance (CL/F), peak concentration
(C), and time to reach C
(T) fell within the 1.25-fold prediction error range.
Sublingual buprenorphine absorption was best described by a
regression model with logarithmically transformed dose. By integrating
this nonlinear absorption profile, the PBPK model adequately predicted
buprenorphine pharmacokinetics (PK) following administration of
sublingual tablets and solution across a dose range of 2–32 mg, with
geometric mean (95% confidence interval) P/O ratios for AUC, CL/F,
C, and T equaling 0.99
(0.86–1.12), 1.04 (0.92–1.18), 1.24 (1.09–1.40), and 1.07
(0.95–1.20), respectively. In conclusion, a fully validated
PBPK model was developed that adequately predicts dose- and
formulation-dependent buprenorphine PK following sublingual
administration. The model forms the foundation on which a fetomaternal
PBPK model for buprenorphine can be built. Fetomaternal PBPK modeling
will allow conceptualization of prenatal buprenorphine exposure and
investigation of its influence on postnatal NOWS severity.
Differential patterns of fish sensitization in Asian populations: implication for precision diagnosis
Authors: Wai Christine Yee Yan , Leung Nicki Y.H. , Leung Agnes Sze Yin , Fusayasu Naoko , Sato Sakura , Xu Kary J.Y. , Yau Yat S. , Duque Jaime Rosa , YW Mike Kwan , Cheng James W. C. H. , Chan Wai Hung , Chua Gilbert , Lee Qun U. , Luk David C.K. , Ho Po K. , SC Joshua Wong , Lam Ivan C.S. , Wong Gary , Ebisawa Motohiro , Leung Ting Fan
Published: July 2022

Background The current diagnostics of fish allergy lack
sufficient accuracy such that more reliable tests such as
component-resolved diagnosis (CRD) are urgently needed. This study aimed
at identifying fish allergens of salmon and grass carp and evaluating
the sensitization pattern towards the identified allergens in fish
allergic subjects from two distinct populations in Asia.
Methods One hundred and three fish allergic subjects were
recruited from Hong Kong (67 subjects) and Japan (46 subjects). Western
blot and mass spectrometry were used to identify allergens from salmon
and grass carp. Fish allergens were purified and tested against 96 sera
on ELISA to analyze patients’ sensitization pattern. The protein
profiles of salmon meat prepared under different cooking methods until
core temperature reached 80°C were evaluated by SDS-PAGE and mass
spectrometry. Results Three common allergens between salmon and
grass carp, namely enolase, glycerldehyde-3-phosphate dehydrogenase
(GAPDH) and parvalbumin, and two salmon-specific allergens collagen and
aldolase were identified. Parvalbumin was the major allergen for both
fishes showing an overall sensitization rate of 74.7%, followed by
collagen (38.9%), aldolase (38.5%) and enolase (17.8%). Japanese
subjects showed more diverse allergen sensitization pattern and more
frequent IgE-binding to heat-labile salmon allergens. Compared with
steaming and boiling, cooking by baking and frying retained more fish
proteins inclusive of heat-labile allergens. Conclusions Fish
allergic patients from different Asian populations show varying fish
allergen sensitization profiles. The relevant extracts and components
for diagnosis are population-dependent but parvalbumin and collagen are
important biomarkers. Cooking methods modify allergen composition of
salmon and appear to influence patients’ allergic manifestations.
Multilevel Modeling of Joint Narrowing in Rheumatoid Arthritis
Authors: Li Hongyang , Guan Yuanfang
Published: July 2022

While deep learning approaches are mostly developed for single images,
in real world applications, images are often taken as a series to inform
decision making. Due to hardware (memory) and software (algorithm)
limitations, so far, no methods have been developed to integrate
multiple images. In this study, we present an approach that seamlessly
integrates deep learning and traditional machine learning, to study
multiple images and score rheumatoid arthritis joint damage. This method
allowed the quantification of joining space narrowing to approach the
clinical upper limit. Beyond predictive performance, we integrated the
multilevel interconnections across joints and damage types into the
machine learning model and revealed the cross-regulation map of joint
damages in rheumatoid arthritis.

Corresponding author(s)
Email:   hyangl@umich.edu or gyuanfan@umich.edu
Exact expressions of the fine structure constant α
Authors: Pellis Stergios
Published: July 2022

In this paper are the exact formulas for the fine-structure constant. A
simple and absolutely accurate expression for the fine-structure
constant in terms of the Archimedes constant π. We propose the exact
formula for the fine-structure constant α in terms of the golden
angle,relativity factor and the fifth power of the golden mean. Also we
will present the continued fraction for the fine-structure constant.
Verbenalin attenuates hepatic damage and mitochondrial dysfunction in alcohol-associated steatohepatitis by regulating MDMX/PPARα-mediated ferroptosis
Authors: Dong Jiahui , Du Changlin , Chuanting Xu , Qi Wang , Zhonghao Wang , Fanle Zeng , Zhenzhen Qian , Zeng Li , Xiongwen Lv , Lei Zhang , Li Jun , Huang Cheng , Ma Taotao
Published: July 2022

Alcoholic steatohepatitis (ASH) is one of the predominant causes of
liver-related morbidity and mortality worldwide. However, effective
therapy for ASH is still lacking. Notably, increasing evidence indicates
ferroptosis may counteract the injury of the ASH. We recently identified
a novel strategy for attenuating ASH by an effective adjuvant via
ferroptosis through targeting MDMX. Verbenalin, which is a major
compound in Verbena officials L (Verbenaceae), is generally recognized
as a kind of safe food by the U.S. Food and Drug Administration. In this
study, we found for the first time that Verbenalin is protective against
alcoholic liver injury through transmission electron microscopy, Fe2+
content detection and other research methods. Its effect can not only
inhibit oxidative stress such as MDA, SOD, GSH, ROS, 4-HNE and other
related indicators, but also inhibit the ferroptosis of hepatocytes
caused by alcohol. It was further confirmed by computer docking that
verbenalin was targeted to inhibit MDMX activity, promote PPAR-alpha
activation, and inhibit alcohol-induced ferroptosis in hepatocytes.
Hence, Verbenalin might be employed as a promising natural supplement
for alcoholic liver injury drug therapy.
Current update of Coriandrum sativum L. (Coriander): potential use on Inflammatory bowel disease.
Authors: Bala Kiran , Melkani Indu , Singh Ajeet , Singh Amar , Kaur Jaspreet
Published: July 2022

Coriander (Coriandrum sativum L.) is a member of the Apiaceae family is
valued for both its cooking and therapeutic use. Various studies shows
that it possesses Anxiolytic, antidepressant, sedative-hypnotic,
anticonvulsant, memory-improving, or facial dyskinesia-improvement,
Neuroprotective, antibacterial, antifungal, anthelmintic, insecticidal,
antioxidant, cardiovascular, Hypolipidemic, anti-inflammatory (IBD),
analgesic, ant diabetic, mutagenic, ant mutagenic, anticancer,
gastrointestinal, deodorizing, dermatological, diuretic, reproductive,
hepatoprotective, detoxification and other various pharmacological
effects. All components of this plant are used as flavouring agents or
as conventional treatments for a variety of diseases mainly Inflammatory
Bowel Disease. The parts of this plant help to treat collitus by
changing the levels of MPO, colon samples, ulcer index. The Coriandrum
sativum phytochemical analysis revealed that it included tannins,
terpenoids, reducing sugars, alkaloids, phenolic, flavonoids, fatty
acids, sterols and glycosides in addition to its essential oil. Linalool
is the main essential oil treating collitus and ulcer. Additionally, it
had a wide variety of minerals, trace elements, vitamins, proteins,
lipids, carbs and fibers with significant nutritional qualities.
Coriander propagate worldwide easily, but mostly grown in India,
Netherlands, Myanmar, Romania, France, Spain, Italy and all other
countries. This review is designed to give an overview on chemical
constituents, cultivation, pharmacological actions traditional uses,
side effects of Coriandrum sativum Linn.
Can SIF and NPQ be used in the photosynthesis rate simulation of plants subjected to drought?
Authors: Shi Shaomin , Lu Sen , Zhao Tianhong , Cong Weiwei , Wang Feng , Lu Qi
Published: July 2022

Solar-induced chlorophyll fluorescence (SIF) has been used to estimate
leaf-level net CO assimilation by a mechanistic light
reaction (MLR-SIF) equation. However, the application of this model
would be limited by the challenging measurement and estimation of input
parameters (e.g. fraction of open PSII reaction centres, q). We modified the MLR-SIF model by replacing q by the easily obtained parameters (non-photochemical
quenching [NPQ]) to facilitate its application. We employed
synchronous measurements of gas exchanges, ChlF parameters and SIF for
Leymus chinensis, Populus tomentosa Carrières and
Ulmus pumila var. sabulosa under the soil–water deficit
and rehydration process to test the robustness of the modified MLR-SIF
model. Our results demonstrated that for L. chinensis the net
photosynthesis rate dynamics under severe soil–water stress and
saturated water condition were effectively captured by the modified
MLR-SIF model ( R = 0.75–0.92, RMSE =
1.11–3.56) . For P. tomentosa Carrières and U.
pumila var. sabulosa, the net photosynthesis rates were
predicted by the modified MLR-SIF model with good accuracy ( R = 0.86, RMSE = 9.44; R = 0.88, RMSE = 4.16) across the water deficit
and rehydration condition . However, the electron transport rate
estimated by the modified MLR-SIF model uncoupled with the
photosynthetic capacity ( r = -0.13) and
lowered the net photosynthesis rate simulation precision ( R = 0.35, RMSE = 3.41) for L. chinensis
under mild drought stress and saturated light intensities. The electron
transport rate estimated by the modified MLR-SIF model downregulated the
photosynthetic capacity for P. tomentosa Carrières ( r = 0.32) and U. pumila var. sabulosa (
r = 0.22) under mild drought stress. The
shift of the Rubisco and RUBP limited state cross-points, the dynamic
photosynthesis parameters across the plant species and the alternative
electron sinks under soil–water deficit and rehydration process
influenced the simulation precision of the modified MLR-SIF model. Our
modified MLR-SIF model provided a basis for understanding and inferring
the photosynthetic rate by SIF and NPQ under water stress.
ALLEVIATION OF SOIL SALINITY EMPLOYING ORGANIC AMENDMENTS TO RESTORE FERTILITY AND SUSTAINABLE PRODUCTION -A COMPREHENSIVE REVIEW
Authors: Neeraj Ajay , Hiranmai R.Y.
Published: July 2022

Agricultural practices modified the soil quality considerably inputs to
the soil in terms of irrigation, fertilizer, and crop variety influenced
soil fertility. The quality and quantity of irrigating water modify
soil’s physical, chemical, and biological properties and productivity.
Soil is affected by natural and anthropogenic activities, and it is
reflected in different agricultural lands. Salinity is one of the
significant issues affecting agriculture by; increasing the soil salt
content and modifying the mineral composition turn imbalances the
organic matter, biotic community, and biogeochemical cycling.
Agricultural, domestic, and industrial activities produce various
organic wastes recycled for soil quality improvement. These organic
sources can be converted to organic matter of soil and balance
exchangeable ions, and manage the soil properties. This review paper is
prepared by referring to the research and review articles published in
reputed journals concerning soil quality, salinity and reclamation of
saline soil using organic wastes, composts, vermicompost and organic
matter. The comprehensive study of research exhibits that the organic
matter from the biowastes can be a resource for modifying the saline
soil and improving crop production.
A genome for Cissus illustrates features underlying the evolutionary success in dry savannas
Authors: Xin Haiping , Wang Yi , Li Qingyun , Wan Tao , Hou Yujun , Liu Yuanshuang , Gichuki Duncan , Zhou Huimin , Zhu Zhenfei , Xu Chen , Zhou Yadong , Liu Zhiming , Li Rongjun , Liu Bing , Lu Limin , Jiang Hongsheng , Zhang Jisen , Wan Jun-Nan , Aryal Rishi , Hu Guangwan , Chen Zhi-Duan , Gituru Robert , Liang Zhenchang , Wen Jun , Wang Qingfeng
Published: July 2022

Cissus is the largest genus in Vitaceae and is mainly distributed in the
tropics and subtropics. Crassulacean acid metabolism (CAM), a
photosynthetic adaptation for the occurrence of succulent leaves or
stems, indicates that convergent evolution occurred in response to
drought stress during species radiation. Here, we provided the
chromosomal level assembly of Cissus rotundifolia (an endemic species in
Eastern Africa) and genome-wide comparison with grape to understand
genome divergence within an ancient eudicot family. Extensive
transcriptome data were produced to illustrate the genetics underpinning
C. rotundifolia’s ecological adaption to seasonal aridity. The modern
karyotype and smaller genome of C. rotundifolia (n = 12, 350.69 Mb/1C),
which lack further whole-genome duplication, were mainly derived from
gross chromosomal rearrangement such as fusions and segmental
duplications, whilst sculpted by a very recent burst of retrotransposons
activity. Bias on local gene amplification contributed to its remarkable
functional divergence with grape and the specific proliferated genes
associated with abiotic and biotic responses (e.g., HSP-20, NBS-LRR)
enabled C. rotundifolia to survive in a hostile environment.
Re-organization of existing enzymes of CAM characterized as diurnal
expression patterns of relevant genes further confer to its present
thriver in dry savannas.
The impact of socioeconomic factors on vegetation restoration in karst regions: a perspective beyond climate and ecological engineering
Authors: Yuan Ershuang , Zhou Qiuwen , Yan Weihong , Peng Dawei , Wang Yalin , Yang Xinglan , Li Ping
Published: July 2022

Socioeconomic factors are important parameters that affect vegetation
changes in karst areas. Previous studies primarily focused on ecological
engineering when analyzing the impact of human activities on vegetation
restoration, whereas the impact of socioeconomic factors has been less
studied. Using the methods of structural equation modeling and
geographically weighted regression, this study quantitatively analyzed
the interactive effects of socioeconomic factors on vegetation changes
in karst areas using counties as the research unit. The results showed
that both the enhanced vegetation index and net primary productivity in
the humid karst areas of China showed an increasing trend between 2000
and 2020. Among the socioeconomic factors, non-agricultural economy and
rural economy had a positive effect on vegetation change, with maximum
path coefficients of the structural equation model of 0.79 and 0.64,
respectively; whereas population pressure had a negative impact with a
minimum path coefficient of –0.80. Over time, the positive impact of
rural economy on vegetation restoration showed an increasing trend, and
the path coefficient increased from –0.92 to 0.64; in turn,
non-agricultural economy and population pressure showed a decreasing
trend. Moreover, because they were affected by the heterogeneity of the
karst mountain environment, the impact of various socioeconomic factors
on vegetation restoration had obvious spatial non-stationarity. The
results of this study will promote our understanding of the mechanism
underlying vegetation change in humid karst areas and provide scientific
reference for ensuring the sustainability of the ecological effects in
these areas.
Forkhead Box i2 (Foxi2) Transcription Factor Regulates Systemic Energy Metabolism Via Neuropeptide AgRP
Authors: Fan Yatong , Sheng Sufang , Guo Cunle , Qiao Wei , Jin Yue , Tan Lu , Gao Yong , Zhang Lei , Dong Xi , Zhang Jun , Li Xiaorong , Shen Hui , Liao Yunfei , Chang Yongsheng
Published: July 2022

The neuropeptide AgRP is essential for maintaining systemic energy homeostasis. In the present study, we show that hypothalamic Foxi2, as a novel regulator of nutrient sensing, controls systemic energy metabolism by specifically stimulating AgRP expression. Foxi2 was highly expressed in the hypothalamus, and its expression was induced by fasting. Immunofluorescence assays demonstrated that Foxi2 was localized in AgRP neurons. We stereotaxically injected AAV to selectively overexpress Foxi2 in AgRP-IRES-Cre mice and found that Foxi2 overexpression in AgRP neurons specifically increased AgRP expression, thereby increasing food intake and reducing energy expenditure, subsequently leading to obesity and insulin resistance. Mechanistically, Foxi2 stimulated AgRP expression by directly binding to it and activating its transcription. Furthermore, Foxi2 overexpression activated AgRP neuron activity, as revealed by whole-cell patch-clamp experiments. Conversely, global Foxi2 mutant mice became leaner with age and were resistant to high-fat diet (HFD)–induced obesity and metabolic disturbances. Collectively, our data suggest that Foxi2 plays an important role in controlling energy metabolism by regulating AgRP expression.
Forkhead box i2 (Foxi2) transcription factor regulates systemic energy metabolism via neuropeptide AgRP
Authors: Fan Yatong , Sheng Sufang , Guo Cunle , Qiao Wei , Jin Yue , Tan Lu , Gao Yong , Zhang Lei , Dong Xi , Zhang Jun , Li Xiaorong , Shen Hui , Liao Yunfei , Chang Yongsheng
Published: July 2022

The neuropeptide AgRP is essential for maintaining systemic energy homeostasis. In the present study, we show that hypothalamic Foxi2, as a novel regulator of nutrient sensing, controls systemic energy metabolism by specifically stimulating AgRP expression. Foxi2 was highly expressed in the hypothalamus, and its expression was induced by fasting. Immunofluorescence assays demonstrated that Foxi2 was localized in AgRP neurons. We stereotaxically injected AAV to selectively overexpress Foxi2 in AgRP-IRES-Cre mice and found that Foxi2 overexpression in AgRP neurons specifically increased AgRP expression, thereby increasing food intake and reducing energy expenditure, subsequently leading to obesity and insulin resistance. Mechanistically, Foxi2 stimulated AgRP expression by directly binding to it and activating its transcription. Furthermore, Foxi2 overexpression activated AgRP neuron activity, as revealed by whole-cell patch-clamp experiments. Conversely, global Foxi2 mutant mice became leaner with age and were resistant to high-fat diet (HFD)–induced obesity and metabolic disturbances. Collectively, our data suggest that Foxi2 plays an important role in controlling energy metabolism by regulating AgRP expression.
Effective Bioconversion of Lignocellulosic Waste to Biodegradable Products for a Cleaner Earth
Authors: P Nair , I Kuriakose , B Das
Published: July 2022

Earth is constantly subjected to dramatic changes due to uncontrolled human activities and this has led to climatic variations associated with global warming resulting in unparalleled greenhouse gas emissions. One of the major causes is solid waste accumulation by human activities ranging from agricultural to industrial activities. The relation between solid waste and climatic change had forced scientists to propose a solid waste management plan to reuse, recycle and create energy from solid waste preventing its accumulation and subsequent pollution. When we consider human activities which are environmentally hazardous; plastic waste accumulation, agricultural wastes disposal and fossil fuel burning holds prominent positions. Plastic wastes. The accumulation of plastic wastes and agricultural wastes pose serious problems of disposal. Plastic wastes are often incinerated or left to be dumped in landfills. Similarly, agricultural wastes are also burnt, releasing a lot of toxic gases into the atmosphere. A common solution to curb both the problems is to streamline the production of bioplastic using agricultural waste (mostly lignocellulose) as a substrate. The third major environmental threat is the increased motor vehicle emission leading to air pollution associated with health threat. The extent of risk ranges from carcinogenic and noncarcinogenic health effects. Carbon dioxide emission by the increasing use of fossil fuels by ever increasing world population not only depletes the resource but also will result in anthropogenic climate change. Therefore, utilization of lignocellulosic waste material as raw material for monomers for bioplastic as well as for bioethanol production can be considered as a productive approach to address all the three problems mentioned above. In addition utilization of fermentation residue after bio products extraction can be used as a soil enriching agent. The intention is converting lignocellulosic waste to zero waste.
Bioprospecting of Marine Bacteria for their Diversity and Biotechnological Application
Authors: D Chettri , AK Verma , AK Verma
Published: July 2022

Microorganisms from marine environments are gaining attention for their idiosyncratic ability to survive in these extreme conditions and been evaluated for their application in bioprospecting. From isolation of enzymes and bioactive compounds possessing peculiar abilities, identification of unique metabolic pathways, to application in health care and bioremediation, extensive study on these organisms is been done with tremendous success. Technological advancement in modern science with regards to Omics technologies integrated with genetic engineering technologies are paving way for isolation of novel organisms and their macromolecules. These bioengineered organisms and enzymes have found their application in industries with high commercial value
Textural and Paleoenvironmental Characterization of the Campano-Maastrichtian Patti Sandstone, Southern Bida Basin, Northcentral Nigeria
Authors: RG Oladimeji , AO Ola-Buraimo
Published: July 2022

Field and granulometric investigation of Patti Sandstone were carried out with a view towards establishing the lithological sequence, geological processes, textural characteristics and paleoenvironment of deposition of the sediments. Field study entailed basic field procedures and sedimentological descriptions which encompass physical factors such as textural parameter, composition, colour and structures; biological inference in terms of fossil content and chemical character in terms of chemical composition and post depositional diagenesis effect. Granulometric laboratory procedure includes weighing and sieving of samples with set of sieves; calculated cumulative percentages, software input of data to generate statistical parameters such as mean, standard deviation (sorting), skewness, kurtosis and ternary diagrams. Field observations show that the lower part of the outcrop section has alternation of claystone and shale; the mid-section shows coarsening-up sequence of shale, clay and sandstone facies of a retrogradational system, while the upper part is composed of intercalation of claystone and sandstone in repetitive pattern, various thicknesses and colours. The textural characteristics of the sandstone are generally coarse-fine grains, reddish to greyish in colour, rounded to subrounded and moderately to well sorted. Structurally, the outcrops are planar cross bedded, wavy laminated and concretional. Granulometric result categorized the sandstones into fine, medium and coarse grained particles; well sorted to moderately well sorted, characterized by lateral retrogradational sequence from the shoreline. The skewness varies from fine skewed, very fine skewed and symmetrical. Kurtosis values suggest multi-sourced particles deposited in marine and fluviatile paleoenvironments.
Logarithm Model for Decline Curve Analysis
Authors: JR Fanchi
Published: July 2022

A decline curve analysis model has been developed for flow rate proportional to the logarithm of time. The logarithm of time model requires careful interpretation of initial time dependence of volumetric flow rate. Applications of the model to shale gas production and shale oil production are presented.
Comparison of medication-related fall risk in hospitalized adults and older people
Authors: Silva Amanda Pestana da , Scwanke Carla Helena Augustin , Pasa Thiana Sebben , Inácio José Francisco Secorun , Rotta Ana Laura Olsefer , Urbanetto Janete de Souza
Published: July 2022

The proposed study aims to verify whether drugs, drug classes, and polypharmacy related to the occurrence of falls are the same for hospitalized adults and older people. The present protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO) (ID: CRD42020208624). The search for articles will be carried out in PubMed, Embase, and in Latin American and Caribbean Literature on Health Sciences (Lilacs) databases. If quantitative analysis is not possible, a synthesis of the present information will be carried out.
Associação entre doenças cardiovasculares e sinais/sintomas do climatério em mulheres atendidas em uma Unidade Básica de Saúde
Authors: Vargas Brenda Ramos de , Burg Maria Renita , Santos Ana Maria Pujol Vieira dos , Morgan-Martins Maria Isabel
Published: July 2022

O presente estudo teve como objetivo avaliar a associação de doenças cardiovasculares (DCVs) em mulheres, no período do climatério/menopausa, de uma Unidade Básica de Saúde do município de Canoas/RS. Este estudo é de caráter descritivo e exploratório. A coleta de dados ocorreu após o projeto ser aprovado pelo Comitê de Ética (CAAE 86378818.1.0000.5349). Todas as participantes assinaram o Termo de Consentimento Livre e Esclarecido (TCLE). Foram utilizados os instrumentos: o questionário sociodemográfico; o questionário validado para o português “Menopause Rating Scale (MRS)” e três perguntas abertas que questionavam se as participantes usavam medicações e se de uso contínuo, bem como se tinham doenças cardiovasculares e a sua percepção da fase do climatério/menopausa. As associações foram analisadas pelo teste de correlação de Spearman, com o nível de significância adotado de 5% (p<0,05), e no programa SPSS versão 21.0. Em relação aos resultados sociodemográficos da amostra a idade média das mulheres foi de 53,3 ± 8,2; destas, 99 (48,5%) tem o ensino fundamental, apenas 98 (48,0%) trabalham; e 196 (96,0%) dessas mulheres têm filhos. A porcentagem de mulheres medicadas para alguma doença cardiovascular foi de 42,16%. As DCVs prevalentes, com diagnóstico, foram angina, dislipidemias, insuficiência cardíaca e hipertensão. A deficiência estrogênica, ainda hoje, é pouco discutida, sendo apenas um ciclo na vida das mulheres; porém, ele desencadeia alterações morfológicas, fisiológicas e interfere no sistema cardiovascular. Por isso, este tema merece uma atenção especial das políticas públicas.
NUANCES DOS SABERES CIENTÍFICOS E PEDAGÓGICOS DE CONTEÚDO EXPRESSOS POR PROFESSORES DE CIÊNCIAS NATURAIS DO ENSINO FUNDAMENTAL
Authors: Oliveira Brito Vilma de , Damasceno Ribeiro Marcel Thiago
Published: July 2022

Este artigo busca contribuir com a compreensão dos Saberes Científicos e Pedagógicos de Conteúdo de professores de Ciências Naturais de uma escola estadual, em Várzea-Grande – MT. Nesse sentido, apresenta-se o problema de pesquisa: como se configuram e se expressam os saberes científicos e pedagógicos de conteúdos de Ciências Naturais subjacentes à docência de professores, ao relatarem o ensino que realizam nos anos finais do Ensino Fundamental? Adota-se uma pesquisa de abordagem qualitativa, a partir da Pesquisa Narrativa. Os instrumentos foram: um questionário e entrevistas semiestruturadas. Os colaboradores da pesquisa são quatro professores de Ciências Naturais. Os resultados evidenciam a legitimidade dos saberes científicos nas metodologias do trabalho pedagógico de todos os professores pesquisados, no entanto, são utilizados, de forma reducionista, apoiados nas literaturas. Pretende-se, no presente estudo, contribuir com os debates para construção de uma base de conhecimentos, envolvendo saberes científicos e pedagógicos de conteúdo de Ciências Naturais.
Tüketicilerin Organik Yumurta Satın Alma Tercihlerini Etkileyen Faktörler; Aydın İli Efeler İlçesi Örneği
Authors: ÇINAR Nurçin , ENGİNDENİZ Sait , ÇINAR Gökhan
Published: July 2022

Amaç; Bu araştırmanın amacı, tüketicilerin organik yumurta satın alma tercihlerini etkileyen faktörleri belirlemektir.Tasarım/Metodoloji /Yaklaşım: Araştırma kapsamında Aydın ili Efeler ilçesinde yaşayan 121 tüketici ile görüşülmüştür. Organik yumurta tüketimini etkileyen faktörler 9 alt boyut ve 33 maddeden oluşan bir ölçek yardımıyla analiz edilmiştir. Ölçeğin alt boyutları normlar, sağlık bilinci, özkimlik, organik gıda tüketmenin faydaları, inanışlar, sosyal kimlik, gıda güvenliği, olumlu ahlaksal yaklaşım ve bilgi aramadan oluşmaktadır. Bu ölçme aracının yapı güvenilirliği Cronbach's Alfa katsayıları ile değerlendirilmiştir. Verilerin değerlendirilmesinde t-testi ve ANOVA testi kullanılmıştır. Bulgular: Araştırmaya 81 kadın, 40 erkek tüketici katılmıştır. Tüketicilerin yaş ortalaması 44.31’dir. Tüketicilerin 62’si organik yumurta tüketirken, 59’u ise organik yumurta tüketmediğini belirtmiştir. Organik yumurta satın almayı etkileyen faktörlerin, normlar, özkimlik, organik ürünlerin faydalarının bilinci, gıda güvenliği, bilgi arama olduğu saptanmıştır. Organik yumurta tüketmeyi tercih edenlerin kadın tüketicilerin ve spor yapan bireylerin beslenmelerinde daha fazla organik yumurta tükettikleri belirlenmiştir. Özgünlük/Değer: Türkiye’de organik yumurta üretimine ve pazarlamasına yön verebilmek ve uygun politikalar oluşturabilmek açısından tüketici tercihleri önemlidir. Bu araştırmanın sonuçlarının bu yönde paydaşlara katkı sağlaması beklenmektedir.
Üreticilerin Damla Sulama Hibelerinden Yararlanma Durumu ve Davranışları: İzmir, Manisa, Denizli Örneği
Authors: ÇELİK Zerrin , ÖZÇELİK Şener , ALBAYRAM DOĞAN Zübeyde , AYDIN Başak
Published: July 2022

Amaç: Tarım ve Orman Bakanlığı tarafından 2012-2017 yılları arasında kırsal kalkınma yatırımları kapsamında İzmir, Manisa ve Denizli illerinde damla sulama hibelerinden yararlanan ve yararlanmayan üreticilerin durumu ile su yönetimine ilişkin tutum ve davranışları karşılaştırılarak ortaya konulmaya çalışılmıştır.Tasarım/Metodoloji/Yaklaşım: Çalışmanın verileri; söz konusu hibeden yararlanan 33 üretici ile hibeden faydalanmayan, ancak damla sulama sistemini kullanan, benzer işletme özelliklerine sahip 33 üretici ile yapılan yüz yüze anket çalışmasından elde edilmiştir. Verilerin analizinde ortalama, standart sapma, yüzde oran gibi istatistikler kullanılmıştır. Damla sulama hibesinden yararlanma durumuna etki eden faktörler ise lojistik regresyon analizi ile değerlendirilmiştir. Bulgular: Elde edilen veriler ışığında, hibeden yararlanan üreticilerin, hibe almayan üreticilere göre daha genç ve daha yüksek eğitimli oldukları; çiftçilik dışında bir mesleğe sahip oldukları; çevre ve doğa bilincinin nispeten daha gelişmiş olduğu görülmüştür. Bununla birlikte hibeden yararlanmayan üreticilerin damla sulama sistemini, sulama hibe ve desteklerinden önce kurdukları tespit edilmiştir.Bulgular: Lojistik regresyon analizi sonuçlarına göre, üreticilerin eğitim süresinin, ailedeki kişi sayısının, tarımda çalışan aile birey sayılarının, tarımsal gelirlerinin ve işlenen tarla arazisi büyüklüğünün damla sulama hibesinden faydalanma durumunu pozitif yönde etkilediği sonucuna ulaşılmıştır. Bu durum, damla sulama hibelerinden gelir seviyesi yüksek, arazi varlığı fazla olan üreticilerin yararlandığını ortaya koymaktadır. Bununla birlikte, su yönetimi ve modern sulama sistemlerinin önemi konularında bilgi yetersizliği olduğu görülmüştür.Özgünlük/Değer: Stratejik bir doğal kaynak olan su, artan talep, iklim değişiminin etkisi ve kalite kayıpları nedeniyle günümüzde daha da önemli bir hale gelmiştir. Ülkemizde mevcut tatlı su kaynaklarının %74’ü tarımsal sulamalarda kullanılmaktadır. Bu nedenle su kullanım etkinliğinin arttırılmasına yönelik modern sulama sistemlerine geçilmesi ve bu sistemlerde doğru bir sulama işletmeciliğinin uygulanması su kaynaklarının korunması bakımından önemli unsurlardandır. Etkin su kullanımı ve yönetimi için modern sulama sistemlerini kullanan üreticilerin durumu ile su yönetimine ilişkin tutum ve davranışları üzerine gerekli çalışmalar yapılmalıdır. Etkin su kullanımı ve yönetimi konusunda bilgi yetersizlikleri ile yanlış uygulamalara yönelik daha fazla yayım ve bilgilendirme çalışmalarının yapılması gerekmektedir.
Pandemi Döneminde Küçük Aile Çiftçilerinin Sorunları Üzerine Nitel Bir Araştırma: Torbalı Örneği
Authors: CANDAN DEMİRKOL Esin
Published: July 2022

Amaç: Bu çalışma pandemi ile gündemimizde önemi artan tarım ve gıda politikalarının küçük üreticiyi nasıl etkilediğini araştırmayı amaçlamıştır.Tasarım/Metodoloj/Yaklaşım: Pandemi süreci devam ederken Torbalı`da üretim yapan küçük ölçekli aile çiftçilerinin bu yeni durum karşısında tutumlarını anlamak çalışmanın temel amacı olmuştur. Çalışmada nitel araştırma yöntemi kullanılmış ve Torbalının 10 köyünde 25 üretici ile `derinlemesine mülakat` görüşmesiyle elde edilen veriler karşılaştırılarak analiz edilmiştir. Bulgular: Pandemiden en çok sebze ve süt üreticilerinin etkilendiği, ancak asıl sorunun tarımdaki yapısal nedenler olduğu bulgularına ulaşılmıştır.Özgünlük: Bu çalışma pandemi sürecinde gıda arz zincirinde oluşabilecek sorunların üstesinden gelmeye yardımcı olabilir
Enkapsulasi Asap Cair Tandan Kosong Kelapa Sawit (Elaeis guineensis Jacq.) dan Uji Aktivitas Antijamur
Authors: Riskawati  , Magfira Nurul , Baharuddin Maswati , Sappewali  , Azis Fitria
Published: July 2022

Oil palm empty bunches is  lignocellulose that can be processed into liquid smoke with the content of acid compounds and phenol compounds that function as a natural preservative. The purpose of this study  to find out the characteristics of liquid smoke, see the effect of encapsulan on the liquid smoke encapsulation  process, and see the antifungal activity of A. flavus and A. niger. The method used is pyrolysis process at a temperature of 400 oC to produce liquid smoke and encapsulation  process by using variation  of coating material using spray dryer with micro sized result. The result showed that the liquid smoke characteristics can be seen from its chemical content that is the dominant phenol compound and has the highest phenol content among the parts found in oil palm that is 68,15%. Based on analysis it can be seen that the best encapsulation process is by the addition of chitosan on maltodextrin with water content 5.78%, phenol content of 43.03 ppm and has a high rate of encapsulation efficiency of 45.87%. The liquid smoke microcapsules could inhibit the growth of fungi with the highest value of liquid smoke concentration, that is 3% with inhibitory value of 8.30 mm.
Analisis Yuridis Terhadap Sengketa Hak Milik Atas Tanah Di Kabupaten Takalar
Authors: Kifliansyah Baso , Marilang Marilang , Talli Halim
Published: July 2022

The main problem of this research is the Juridical Analysis of Land Ownership Disputes in Takalar Regency. This research is descriptive research using qualitative data, data obtained through field studies (Field Research). so that the data collection method is sourced from informant data from both the Plaintiff and the Defendant, the Takalar District Court, and from the government in this case the Lakatong Village. Data was collected through the methods of observation, interviews and documentation. Furthermore, the data obtained will be analyzed through a Juridical Sociology approach. The conclusions from the results of this study are: 1) the problem is that the land located in Kaporengeng, Lakatong Village, Manggarabombang District, Takalar Regency (the object of the current dispute) is the land owned by Samsu B Peleng based on the detailed letter of Pesil No. 8a D1 Kohir 30 covering an area of ​​± 10 acres (1000 m²) with boundaries according to the results of local inspections, 2) based on legal considerations for the petitum which basically states that ACCUSED I controls the Disputed Land I, Rinkik land with an area of ​​:±4Are(± 400M2 Lompo Kaponrengang Persil No. 8a D1 Kohir Number 30 is an unlawful act (onrechtmatige daad) and ACCUSED II is in control of Disputed Land II, detailed land with an area of ​​:±2Are (±200M2 Lompo Kaponrengang Persil No. 8a D1 Kohir Number 30 is an act Against the law (onrechtmatige daad), 3) ​​Dictum / Amar Decision is to partially grant the claim of the plaintiffs.

Keyword: Land Dispute, Property Rights
ISLAMIC CRIMINAL LAW ON JARIMAH ZINA'S TESTIMONY: UNCOVERING THE CONFLICTS BETWEEN SHARIA DOCTRINE AND REALITY
Authors: Haq Islamul , Marilang  , Kurniati
Published: July 2022

The purpose of this study was to examine the orientalist N.J. Coulson's point of view on the discrepancy between the doctrine of Sharia and reality in the case of adultery in the evidence of a witness. This research was qualitative in nature and employed a descriptive normative juridical technique to answer the research questions. Documenting data, conducting data analysis through reduction, presenting data and drawing conclusions were all examples of data collection techniques. With regard to the testimony of adultery, the researcher aimed to uncover and then offer evidence regarding the disagreement between Sharia doctrine and reality in order to better understand the phenomenon. Based on the findings of the study, it could be stated that Islamic Sharia is a Sharia that places a great value on human honor, and that hifz al-irdh was one of the maqashid sharia, or honor code. With the introduction of hifz al-'irdh, the Islamic Criminal Law had strengthened the requirement for four witnesses to testify in an adultery case. This was also consistent with the punishment for adultery, which might range from stoning to death. However, the criticism levelled against N.J. Coulson regarding the seeming conflict between Sharia doctrine and reality in terms of the strictness of testimony was essentially incorrect, as Islamic law granted the privilege of maintaining human honor (hifz al-'irdh) rather than a conflict.
THE EFFECT OF LEARNING MOTIVATION AND PARENTS’ ROLE ON THE ACHIEVEMENT INDEX IN PGMI STUDENTS' ONLINE LEARNING
Authors: Pramusinta Yulia , Faizah Silviana Nur
Published: July 2022

Abstract

COVID-19 became a problem in Indonesia, especially in education. The whole educational level ranging from basic to higher education is required to learn from home or online. This study aimed to find: (1) the learning motivation effect on the Achievement Index (AI), (2) the parents’role effect on AI, and (3) the interaction of learning motivation and parents’ role in AI. This research used a descriptive quantitative method with a google form survey approach. The sample in this study was 154 students of PGMI study program for the even semester in 2020/2021. The analysis technique used was multiple linear regression analysis to test three hypotheses. The results showed that: (1) there was an influence of learning motivation on students' AI, (2) there was an influence of parents' role on AI, and (3) there was an interaction between learning motivation and parents' role in students' AI.
PENGGUNAAN MEDIA PEMBELAJARAN POSTER BERBASIS PENDEKATAN SAINTIFIK TERHADAP KEMAMPUAN KOGNITIF PESERTA DIDIK
Authors: Munirah Munirah , Rosdiana  , Hadmawati Nurul
Published: July 2022

Abstrak

 Penelitian ini bertujuan untuk mengetahui pengaruh penggunaan media pembelajaran poster berbasis pendekatan saintifik terhadap kemampuan kognitif siswa khususnya mata pelajaran Pendidikan Agama Islam pada siswa kelas V SDI Kecamatan Raulo Kabupaten Parigi Kabupaten Gowa. Penelitian ini menggunakan tipe ex post facto. Populasi dalam penelitian ini adalah siswa SDI Raulo yang berjumlah 17 siswa. Hasil penelitian menunjukkan bahwa: (1) nilai rata-rata penggunaan media pembelajaran poster di SDI Roulo masih dalam kategori sedang, dengan capaian maksimal 84 dan minimal 68; (2) rata-rata skor kemampuan kognitif siswa kelas V SDI Raulo berada pada kategori sedang dengan prestasi belajar maksimal 87 dan minimal 76; dan (3) ada pengaruh penggunaan media pembelajaran poster terhadap kemampuan kognitif siswa pada pembelajaran PAI. Guru hendaknya menggunakan media pembelajaran seperti poster untuk menarik minat siswa dalam mempelajari pelajaran pendidikan agama Islam.
PEMAHAMAN KONSEP PERKALIAN DENGAN MENGGUNAKAN METODE RME PADA PESERTA DIDIK KELAS III MI MIFTAHUL HUDA
Authors: Indriani Nina , Salsabila Zuha Prisma , Firdaus Alfira Nur Azizah
Published: July 2022

Abstrak

Tujuan penelitian ini adalah untuk mengetahui sejauh mana pemahaman peserta didik mengenai operasi hitung perkalian dengan menggunakan metode RME. Sampel dalam penelitian ini ialah peserta didik kelas 3 di MI Miftahul Huda sebanyak 28 siswa dipilih mengunakan purposive sampling. Penelitian ini menggunakan metode kuantitatif kuasi eksperimen dengan jenis the time series experiment. Hasil penelitian menunjukkan bahwa pemahaman perkalian siswa meningkat. Indikator perkalian yang terpaku dengan hafalan, konsep perkalian dengan penjumlahan berulang, konsep sifat-sifat perkalian, dan pengaplikasian konsep perkalian ke dalam soal cerita menunjukkan peningkatan, sehingga dapat disimpulkan bahwa pemahaman konsep perkalian peserta didik kelas III MI Miftahul Huda Jatisari mengalami peningkatan yang signifikan. Peserta didik telah mampu memahami konsep matematika sederhana dan membuktikannya tanpa selalu berpaku pada hasil hafalan mereka.
The Pregnancy care and baby parenting patterns in toraja ethnics
Authors: Bahar Hartati , Powatu Karlina
Published: July 2022

One of the causes of the high maternal mortality rate in Indonesia is the limited knowledge of the community and the existence of cultural influences. This study aims to analyze in depth the pattern of maternity care and infant care patterns in the Toraja ethnicity in the working area of ​​the Mekar Public Health Center, Kendari City. The type of research used is qualitative research with a phenomenological approach. The results showed that the pattern of maternity care and baby care in terms of elemental assessment in the Toraja tribe, namely the behavior that was more recommended, namely moving a lot, light exercise and walking; abstained behavior is not allowed to cut nails, cut hair, bathe after 4 pm, not allowed to sit at the door, not allowed to put a towel around his neck; preferred foods are katuk leaves and nuts; The foods that are abstained are bananas, pineapples, and durians, spicy foods and coconut milk. In terms of the prescriptive elements in the Toraja tribe, namely pregnancy checks, infant feeding, namely breastfeeding and complementary feeding such as red flour porridge, Ambon banana and mixed porridge after 6 months and over, and massage therapy. In terms of cognitive elements, the Toraja tribe has trust during pregnancy, but in terms of baby care, they have certain trust in baby caretakers in terms of views about the placenta, namely aluk ma'lolo. Therefore, education with a local culture approach can still be carried out as long as safe for mother and children
Descriptive Study of Cadre Knowledge About Filling in KMS at Simpang Baru Health Center Pekanbaru
Authors: Riana Helma , Rustam Musfardi
Published: July 2022

Posyandu activity one of the activities is to monitor the growth of children under five through KMS. Based on data from the Pekanbaru City Health Office, it is known that the highest number of cadres is in the Simpang Baru Pekanbaru Health Center. The purpose of this study was to Determine The Knowledge Of Cadres About Filling KMS Toddlers in Puskesmas Simpang Baru Pekanbaru Years 2015. This research uses quantitative research. Based on the description of the results of research on cadre knowledge about KMS in the Simpang Baru Pekanbaru Puskesmas in 2015, the researcher can conclude that the majority of respondents lack knowledge about KMS as many as 31 people (68.9%). The research sub-variables can be identified as follows: the majority of respondents lack knowledge about KMS by 25 people (55.6%), lack knowledge about the causes of hypertension by 21 people (46.7%), and lack knowledge about how to fill KMS by 27 people (60.0%).