bluuebunny/crossref_metadata_2025 huggingface dataset:
Prevention of doxorubicin-induce renal function abnormalities by turmeric in Wistar rats
Authors: Isirima Joshua Charles  , Okoroafor Dorcas Okayo
Published: March 2021

Doxorubicin is an anthracycline antibiotic with anti-neoplastic potentials mediated mainly by affecting the DNA synthetic machinery of the cell. It is found to be effective against a wide range of cancers including the ovary, uterus, lung, breast etc. Doxorubicin exerts its nephrotoxicity on the kidney by inducing inflammatory changes leading to increased capillary porousness and glomerular shrinking. This study investigated the effect of turmeric on the renal function biomarkers in doxorubicin-induced oxidative stress in Wistar rats. 54 adult Wistar rats were divided into 9 groups of six animals each. Group 1 animals served as control (normal saline), group 2 animals served as negative control, and received doxorubicin, group 3 animals were given doxorubicin and turmeric, group 4 animals received doxorubicin and vitamin C, group 5 animals received doxorubicin and vitamin E, group 6 animals received doxorubicin, vitamins C and turmeric, group 7 animals received doxorubicin, vitamin E and turmeric, while group 8 animals received doxorubicin, vitamin C and vitamin E and finally, group 9 animals receive doxorubicin, vitamin C, vitamin E and turmeric. The experiment lasted for 28 days and blood samples were collected from each animal from the various groups for renal function assay. Doxorubicin caused significant increase in the serum levels of urea, creatinine, sodium (Na+), calcium (Ca2+), and decrease serum levels of chloride (Cl-), magnesium (Mg2+) and potassium (K+). These abnormal electrolyte imbalances were prevented by administration of turmeric alone or in combination with vitamins C and or E along with doxorubicin concomitantly.
Atomic kernels as waves and catastrophes
Authors: Gudrun Kalmbach HE
Published: March 2021

The presentation of atomic kerrnels as particles requires for the physics duality principle that they get a wave description. This is due to presenting the SU (3) GellMann matrix space by octonians which are obtained by doubling the spacetime quaternions. Their multiplication table is different from the SU (3) matrices. The third presentation of this space is a complex 4-dimensional space where the real spacetime coordinates of a 4-dimensional Euclidean Hilbert space R4 are extended to C4. For getting from Deuteron Cooper pairs NP of a neutron and proton atomic kernels AK, the wave package superpositions for AK need the mass defect of neutrons where kg is changed to inner speeds or interaction energies. For kg octonians have a GF measuring base triple as Gleason operator. Using a projective geometrical norming, C4 is normed to CP³, a projective 3-dimensional space. Its cell C³ has spacetime coordinates C², extended by an Einstein energy plane z3 = (m,f), m mass, f = 1/∆t frequency where mass can be transformed into f by using mc² = hf. If C³ is presented as a real space R6, it can be real projective normed to a real projective space P5 for the field presentation of AK. As field the NP‘s have then a common group speed for AK wave packages superpositions with which AK moves in spacetime C² and also a presentation as a Ψ wave. As probability distribution where they can be energetically found in space serves Ψ* Ψ.
Evaluation of Streptomyces species from historically sewage sludge contaminated soils for tolerance to copper(II) toxicity
Authors: Ifunanya R. Akaniro  , Joy U. Nwankwo  , Chiamaka M. Adinnu  , Uchechukwu Okekeaji  , Francis A. Gbadamosi
Published: March 2021

Pollution of the environment by copper(II) exerts numerous adverse impacts on soils, microorganisms, plants, animals and humans. Assessing these impacts on microorganisms is essential as they are potential agents of bioremediation to purify the ecosystem. The aim of this study was to investigate the tolerance of Streptomyces species obtained from historically contaminated soils to copper (II) toxicity. Soil samples were collected from farms around sewage sludge dump sites (tests) and where there were no dumps (control). Standard microbiological methods were used to isolate, characterize and identify the three best copper tolerant species. Also, the impact on Streptomyces growth characteristics such as radial growth (R2), index of growth (GI) and percentage inhibition of radial growth (PIRG) by copper (II) was examined. Results obtained indicated that; the minimum inhibitory concentration of copper (II) for some of the Streptomyces isolates was 600 mg/l. However, three isolates; SW2B, SW7A and SW7B had MIC of 3000 mg/l and were selected for further investigations. Increasing metal concentration from 100 mg/l to 2000 mg/l reduced R2 from 40.2 to 4.0 and GI from 0.77 to 0.08, corresponding to 69.48 % increase in PIRG for SW2B. For isolate SW7A, R2 and GI decreased from 33.7 to 3.8 and from 0.67 to 0.08 respectively as copper (II) concentration increased from 100 mg/l to 2000 mg/l, giving 59.33 % increase in PIRG. The highest increase in PIRG (88.04 %) was obtained for SW7B, corresponding to a decrease of R2 and GI from 39.2 to 5.2 and 0.77 to 0.10 respectively. Molecular method was used to identify the isolates as Streptomyces chartreusis (SW2B), Streptomyces aureoverticillatus (SW7A) and Streptomyces subrutilus (SW7B).
Morphometric characterization of Rastrococcus invadens on four varieties of mango trees (Pout, Thies)
Authors: Amadou Fall  , Adiouma G.R. J. Sarr  , Fawrou Seye  , Mamour Toure  , Raymond D. Ndione  , Mady Ndiaye
Published: March 2021

Rastrococcus invadens (Homoptera, Pseudococcidae) or mealybug is an insect pest of mango and several other fruit trees including citrus. The cochineal is native to Southeast Asia and was first identified in Senegal in Dakar in 1995. Since then, it has been widely distributed throughout the country and more particularly in the two most fruit-producing areas: Casamance and Thies. To properly conduct our study, we chose the four most infested mango varieties namely Kent, Keitt, Sewe and Boukodiekhal. All these populations are from the locality of Pout (Thies region). On each plant we collected 10 people. This allowed us to have a total of 40 individuals. The individuals harvested are coded according to the zone and the type of plant in which they were harvested. This study revealed almost two more or less distinct morphometric groups made up on the one hand by populations from improved varieties (Kent and Keitt) and on the other by those from local varieties (Sewe and Boukodiekhal).
The anxiolytic effect of some plant extracts in clinical trials and animal models
Authors: Malkhaz Makashvili  , Giorgi Andronikashvili  , Tamila Bagashvili  , Tea Gurashvili  , Ketevan Gogeshvili  , Tamar Nadiradze  , Nino Akhobadze
Published: March 2021

The phenomenon of anxiety remains poorly understood and there is much to be learnt about its’s effective treatment. Here we discuss the data of available scientific literature concerning the use of plant derived extracts in the treatment of anxiety. Study of the treating effects of natural alternatives to prescription drugs is very important in regard to limitations of current drug therapies. Significance of the study of treating efficacy of endemic plant species, endemic to Georgia in particular, and the use of animal models, such as rat grooming and rat behavior in maze, for evaluation of the anxiolytic efficacy of phytomedicines is discussed as well. We conclude, that medical as well as experimental trials in animal models of anxiety provide strong argument for the use of plant extracts as an alternative to the current drug therapies for anxiety.
Tyra Kleen
Authors: Ström Lehander Karin
Published: March 2021

The Swedish artist and writer Tyra Kleen (1874–1951) was a professional artist and a constant traveller who had a great interest in different religious questions. This article describes her Symbolist artistry, her interest in Theosophy and her journeys to India and Asia.
Seekers of the spiritual art and higher wisdom
Authors: Kokkinen Nina , Illman Ruth
Published: March 2021

Editorial of Approaching Religion, Vol. 11 Issue 1,  based on a two-day seminar arranged in Helsinki in August 2020 by the Signe and Ane Gyllenberg Foundation under the title ‘Clear-sighted Art – Open Mind? Encounters between Art and Esotericism’.
Sigrid af Forselles and ‘The Development of the Human Soul’
Authors: Lahelma Marja
Published: March 2021

The five-part relief series The Development of the Human Soul (c.1887–1903) by the Finnish sculptor Sigrid af Forselles is a monumental work consisting of five large plaster reliefs. The artist’s esoteric interests have been noted in previous research, but their impact on her art has not been properly analysed. The first part of the relief series, which has for its subject a theme from Scandinavian mythology, belongs to the collections of the Finnish National Gallery, while the other parts, with seemingly Christian content, are situated in the Kallio Church in Helsinki. The separation of the parts and the apparent inconsistency in the thematic structure of the series has caused confusion among those who have attempted to interpret it as a whole, although occasionally a possible Ttheosophical inspiration has been suggested. This article presents the first attempt at a more profound, esoteric interpretation of the series, arguing that its main theme is a spiritual evolution that attaches itself to the idea of progress and liberation through art. The narrative evolves from materiality and physical strength towards spirituality and immateriality.
Dance as a contemplative practice
Authors: Hellsten Laura
Published: March 2021

This article analyses ethnographic material gathered in Sweden amongst dancers in the Church of Sweden. With the help of the writings of Sarah Coakley and Simone Weil I explore if, and how, dancing could be considered a contemplative practice in the Christian traditions of the Latin West.
Evaluation of dietary supplementation of fenugreek seed (Trigonella foenum-graecum L.) as a growth promoter in broiler diet and its impacts on growth performance, carcass quality and cost effectiveness
Authors: HASSAN ALİ Abdimajid , YEASMIN Tahera , MOHAMED Yonis Abukar , MOHAMUD Abdiaziz İdiris , MISHRA Pravin
Published: March 2021

This study was carried out to evaluate the efficacy of Fenugreek seeds (Trigonella foenum-graecum L.) on overall performance of broiler. A total of 96-day old Cobb-500 chicks were randomly divided into four dietary treatment groups namely 0, 1, 2 and 3 having three replications in each treatment group. Brooded chicks were randomly separated into replications wise separate pen to rear up to 4 weeks. Each treatment group contains 24 birds (8 birds in each replication). Experimental birds in 1, 2 and 3 were provided fenugreek seeds meal with 0.5%, 1% and 1.5% of feed while 0 was provided with standard feed and considered as control group. The results of this study were indicated that final live weight gain and feed efficiency of birds was significantly (P<0.05) higher in 3 compared to 2, 1 and 0 respectively. The result also indicated that feed efficiency was increased at dose rate of 1.5% fenugreek seeds meal in 3 compared to 2 1 and control 0 group respectively. In case of meat yield parameters there was significant (P<0.05) difference among treatment groups except liver weight. The carcass weight was significantly (P<0.05) higher in 3 group compared to the control group. The lowest feed cost was found in 0 and highest profit in 3 group. Based on the current study, it is concluded that fenugreek seed meal at a dose of 1.5% can be used as growth promoter for the production of broiler chicken.
Enhancing the extraction of pumpkin seed (Cucurbita pepo L) for increasing oil yield and its phytosterol content
Authors: Hien Tran Thi , Minh Nguyen Thi
Published: March 2021

Pumpkin seeds (Cucurbita pepo) were harvested in 2018 containing 41.23±1.23% oil; 33.18±1.61% protein; and 1575.97 ±67.79 mg phytosterol in 100g seeds (dried weight). Solvent (hexane) extraction (SE), Ultrasound assisted solvent (hexane) extraction (UAE), Enzyme Alcalase assisted extraction (EAE) and Enzyme Alcalase_Ultrasound assisted extraction (E_UAE) were studied. The oil’s yields and phytosterol in oil obtained were 90.07±0.17% and 1657.6±82.9 mg/100ml oil; 95.46±0.06% and 2017.5±100.1 mg/100ml oil; 89.65±0.11% and 1992.7±99.5 mg/100ml oil; 91.87± 0.03% and 2327.7 ±110.4 mg/100ml oil, respectively. The highest oil yield of 95.56% was obtained when UAE method was applied, while it was found that the highest phytosterol content of 881.7 mg/100g seeds can be obtained in the case of using E_UAE.
Analisa Bauran Pemasaran (Marketing mix) Jasa Penginapan Berbasis Syariah Di Hotel Sofyan Inn Srigunting Bogor.
Authors: Djunaid Ika Suryono
Published: March 2021

ABSTRAK
Latar belakang penelitian ini adalah adanya fenomena pariwisata syariah yang merupakan konsep yang mengintegrasikan nilai-nilai syariah ke dalam kegiatan-kegiatan pariwisata dengan menyediakan fasilitas dan layanan yang sesuai dengan ketentuan syariah tidak terkecuali hotel syariah sebagai salah satu bentuk fasilitas layanan dalam pariwisata syariah yang memberikan bentuk layanan hospitality. Penelitian ini bertujuan untuk mengetahui sejauh mana strategi pemasaran jasa berbasis syariah di Hotel Sofyan Inn Srigunting Bogor. Penelitian ini menggunakan metode kuantitatif deskriptif, dengan menyebarkan kuesioner  kepada para tamu untuk mengetahui bagaimana pelayanan yang di rasakan oleh para tamu di hotel Sofyan Inn Srigunting Bogor. Kesimpulan dari penelitian ini adalah bauran pemasaran jasa berbasis syariah di Hotel Sofyan Inn Srigunting Bogor sudah berjalan dengan sangat efektif. Apabila di tinjau dari keseluruhan adalah baik dengan nilai rata-rata 405. Namun perlu adanya sedikit perbaikan mengenai varian tipe kamar untuk menambah kepuasan tamu di Hotel Sofyan Inn Srigunting Bogor.

Kata kunci :

Bauran Pemasaran, Hotel Syariah,
PENGARUH BAURAN PEMASARAN TERHADAP VOLUME PENJUALAN KAMAR DI AMARIS HOTEL DIPONEGORO YOGYAKARTA
Authors: Hayati Rafika , Achmadi Nila Sartika
Published: March 2021

Persaingan dalam dunia perhotelan semakin meningkat dengan berbagai penawaran yang kompetitif sehingga perlu melakukan strategi dalam pemasaran produk maupun jasa yang ditawarkan melalui Bauran Pemasaran. Pada Hotel Amaris Diponegoro Yogyakarta mengalami penurunan volume penjualan dalam menawarkan produk maupun jasa yang ditawarkan hal ini disebabkan telah banyak hotel yang berkembang dengan menawarkan produk yang baru. Penelitian tugas akhir bertujuan untuk mengetahui berapa besar pengaruh bauran pemasaran terhadap volume penjualan kamar di Amaris Hotel Diponegoro Yogyakarta. Variabel independen dalam penelitian ini meliputi Bauran Pemasaran yang terdiri dari indikator produk, harga, promosi, tempat, bukti fisik, orang, proses. Sedangkan variabel dependen yang meliputi Volume Penjualan terdiri dari dua indikator yaitu intensitas pembelian dan arus perusahaan. Populasi dalam penelitian ini adalah seluruh tamu yang berkunjung di Hotel Amaris Diponegoro Yogyakarta terhitung pada bulan Januari sampai bulan Maret. Penentuan sampel dalam penelitian ini menggunakan rumus Slovin dengan total sampel sebanyak 99 tamu dengan menggunakan teknik insidental sampling. Teknik pengumpulan data yang digunakan oleh peneliti yaitu studi literatur dan angket yang dianalisis dengan menggunakan uji Asumsi Klasik dan Regresi Linear Sederhana. Berdasarkan dari hasil perhitungan Koefisien Determinasi Bauran Pemasaran berpengaruh langsung terhadap Tingkat Penjualan Kamar di Hotel Amaris Diponegoro Yogyakarta sebesar 51,2% dan sisanya sebesar 48,8% dipengaruhi oleh faktor lain di luar variabel Bauran pemasaran yang tidak diteliti lebih lanjut oleh penulis..

Kata kunci: Industri Hotel, Bauran Pemasaran, Volume Penjualan.

 

 

 

 

 
Pembuatan Dodol sebagai Atraksi Wisata di Perkampungan Budaya Betawi Setu Babakan. Studi Kasus : Dodol Nyak Mai di Perkampungan Budaya Betawi Setu Babakan
Authors: Adiati Maria Pia , Levyta Farah , Wahyuningtias Dianka
Published: March 2021

ABSTRACT

 

Setu Babakan Cultural Village is a Betawi cultural reserve area. So far, people know Setu Babakan only to enjoy and see Betawi culture. But not many know that there is a Betawi Dodol producer that has long been established. Making Betawi Dodol should be a tourist attraction because of its uniqueness and take long process. The organier of Setu Babakan Betawi Village has indeed provided a visiting package for Dodol making workshops, but this method has not attracted many tourists to witness the process of making Betawi Dodol. This research was carried out in qualitative and quantitatively descriptive ways. The results of this study were to recommend the organier of Betawi Cultural Village in coordination with the producer Dodol Nyak Mai to make a schedule for making dodol that could be visited and the schedule was published through social media and cooperating with tourism schools.

Keyword: Cultural Village, Culinary, Dodol, Betawi

 

ABSTRAK

 

Perkampungan Budaya Setu Babakan merupakan kawasan cagar budaya Betawi. Selama ini orang mengenalnya hanya untuk berekreasi dan melihat kebudayaan Betawi. Tetapi  belum banyak yang tahu bahwa disana ada produsen Dodol Betawi yang sudah lama berdiri. Pembuatan Dodol Betawi semestinya dapat menjadi atraksi wisata karena prosesnya yang unik dan panjang. UPK Perkampungan Budaya Betawi Setu Babakan memang sudah menyediakan paket kunjungan untuk workshop pembuatan Dodol, tetapi cara ini belum banyak menarik minat turis untuk menyaksikan proses pembuatan Dodol Betawi. Penelitian ini dilakukan dengan  caradeskriptif  kualitatif dan kuantitif. Hasil dari penelitian ini adalah merekomendasikan UPK Perkampungan Budaya Betawi berkoordinasi dengan produsen Dodol Nyak Mai untuk membuat jadwal pembuatan dodol yang dapat dikunjungi dan jadwal tersebut dipublikasikan  lewat sosial media maupun bekerjsama dengan sekolah pariwisata.

Kata kunci: Perkampungan Budaya, Budaya Kuliner Dodol, Betawi
PENGARUH MOTIVASI DAN LAYANAN TERHADAP KEPUTUSAN BERKUNJUNG WISATAWAN NUSANTARA KE MUSEUM SUMPAH PEMUDA
Authors: Meiliana Sherly , Dewantara Yudhiet Fajar
Published: March 2021

Kunjungan wisatawan yang setiap tahun meningkat secara signfikan dan ulasan positif yang diberikan wisatawan terhadap Museum Sumpah Pemuda, terutama untuk motivasi dan layanan terhadap museum, maka tujuan dari penelitian ini adalah untuk mengetahui apakah faktor motivasi dan layanan memang mempunyai pengaruh dan bagaimanakah pengaruh tersebut terhadap keputusan berkunjung wisatawan nusantara ke Museum Sumpah Pemuda. Jenis penelitian yang digunakan adalah Kuantitatif dengan analisis statistik regresi linear berganda, penelitian ini menggunakan teknik pengambilan sampel probability sampling dengan pendekatan simple random sampling dengan kriteria sampel wisatawan nusantara yang sudah pernah berkunjung ke Museum Sumpah Pemuda sebanyak 100 responden yang diambil menggunakan kuesioner melalui Google Form. Analisis data yang digunakan adalah analisis pengujian validitas, reliabilitas, uji asumsi klasik, analisis regresi linear berganda (uji-t dan uji F) dan determinasi. Data pada penelitian ini diolah menggunakan SPSS Statistic versi 22. Hasil analisis regresi linear berganda menunjukkan bahwa Motivasi dan Layanan mempunyai hubungan yang positif terhadap Keputusan Berkunjung, hasil uji-t menunjukkan bahwa Motivasi dan Layanan mempunyai pengaruh yang signifikan terhadap Keputusan Berkunjung dan hasil uji F menunujukkan bahwa Motivasi dan Layanan mempunyai berpengaruh secara simultan terhadap Keputusan Berkunjung, dimana hasil koefisien determinasi menunjukkan bahwa Motivasi dan Layanan berpengaruh terhadap Keputusan Berkunjung sebesar 66,9%. Simpulan dalam penelitian ini adalah bahwa motivasi dan layanan dapat mempengaruhi keputusan berkunjung
Farmacias comunitarias de Ecuador y España. Aspectos legales
Authors: Fernández Rodríguez María , Martínez Martínez Fernando , Iñiguez-Pineda Debbie , Morales-Flores Myriam , Cabezas-López María Dolores , García Corpas José Pedro
Published: March 2021

Introducción: La necesidad de estándares de calidad de los servicios farmacéuticos, para garantizar el uso seguro, responsable y efectivo del medicamento, ha hecho que a través de los años se produzcan una serie de cambios en los sistemas sanitarios. Existe además, una lucha para posicionar a la farmacia y a farmacéuticos como ejes potenciales para promulgar la protección de la salud. Fruto de estos cambios, se evidencian diferencias estructurales en los modelos de farmacia entre países desarrollados y países en vías de desarrollo. El presente estudio realiza un análisis comparativo del modelo de oficina farmacia entre los países de Ecuador y España, diferenciando las legislaciones alusivas al funcionamiento de las farmacias y comparando los modelos de oficina de farmacia.

Método: Estudio comparativo basado en investigación documental, en lo referente a normativas y legislación de las farmacias comunitarias de Ecuador y España

Resultados: En el presente trabajo se analizan la legislación vigente que regula la farmacia española y ecuatoriana, en referencia al establecimiento de nuevas farmacias, propiedad farmacéutica, prohibición de cadenas de farmacia, así como la calidad de la formación del farmacéutico comunitario

Conclusiones: En países de Latinoamérica, como en el caso de Ecuador, la farmacia adopta un modelo más liberal, refiriendo a la desregularización de la apertura de nuevas farmacias, temas de propiedad, sistema de planificación territorial, así como la no presencia del profesional farmacéutico; dando lugar a un sistema con un fuerte enfoque comercial; incidiendo de esta forma sobre la función ideal que debe llevar a cabo la farmacia comunitaria.
Prevalence of Anemia in Children of Rural Population of Northern State of India
Authors: Mehta Geetika , Sachdeva Monika , Tripathi Rashmi
Published: March 2021

Introduction: India carries the highest burden of anemia, particularly in children and women. Children at the growing stage are at the risk of nutrition depletion, hence anemia. Fewer data are available on the prevalence of anemia in growing children of age 10-14 years. It is important to intervene early and track this group. The objective of the present study was to estimate the prevalence of anemia and its correlation to age, gender and body mass index in children of rural area of Ghaziabad, Uttar Pradesh, India.

Method: Total 600 children of 5-13 years age group were included in this study. A detailed questionnaire was used to collect the health details of the children and socioeconomic status of the parents. Hemoglobin was determined by the calibrated Hemoglobin analyzer. Body mass index values were calculated based on the measurements of weight and height of the children.

Results: Prevalence of anemia as per WHO standards in these children was 57.67%. Results of the study population reveal that anemia in this region is more prevalent in girls (68%) when compared to boys (47.3%). However, association between body mass index and hemoglobin was not statistically significant in the present study.

Conclusions: Our results suggest that increased prevalence of anemia in the children of rural area is associated with multiple nutrient deficiencies. Nutritional interventions, evaluation of predisposing risk factors and increased coverage of supplementation programme are recommended measures that can be adopted to control anemia in children.
Resistance evaluation of nonmetallic elements of pneumatic suspension of machines to influence of negative temperatures
Authors:   Moscow Automobile and Road Construction State Technical University (MADI), Marenkov I. G. , Baurova N. I. ,   Moscow Automobile and Road Construction State Technical University (MADI)
Published: March 2021

The operation conditions of nonmetallic elements of the pneumatic suspension of road-making machines have been studied and analyzed. Evaluation of the strength characteristics of the nonmetallic elements of the pneumatic suspension under the influence of negative temperatures was carried out. It was found out by experiments that the influence of negative temperatures resulted in an increase in stiffness of a rubber part of an air cell. It was determined that for increasing resistance of the nonmetallic elements of the pneumatic suspension to the influence of negative temperatures it was necessary to use anaerobic impregnating compounds.
Road environmental impact assessment in the conceptual design stage - example of the Kragujevac - Mrčajevci motorway
Authors: Fric Sanja , Ilić Vladan , Lukić Miloš , Gavran Dejan , Trpčevski Filip , Vranjevac Stefan
Published: March 2021

The construction of new motorway routes leaves lasting consequences on the nature and the living world along the corridor through which the adopted motorway alignment extends. Therefore, it is necessary that in the initial stage of the project (Conceptual design) the analysis of all potential impacts of the motorway on the environment be done very rigorously. The subject of this paper is the road environmental impact assessment methodology implemented in conceptual design of Kragujevac - Mrčajevci motorway. Within the motorway environmental assessment for different variants of motorway corridor, traffic noise, air pollution, rainwater and groundwater pollution, soil pollution, climate change, occupation of surfaces for expropriation and other relevant impacts were investigated. In the paper the methodology used to assess the initial ("zero") state of the environment in the studied area was briefly described. In addition, the methodology based on which the project alternatives were compared regarding environmental requirements was also presented, and finally, what was the conclusion of such a comparison.
Delivery of goods by courier services, before and during the Covid-19 virus epidemic
Authors: Ivanisevic Tijana , Simović Sreten
Published: March 2021

This paper presents the results of a survey of respondents' attitudes related to the delivery of goods, ordered online, by courier services, in the period before and during the epidemic of the COVID-19 virus. The aim of the study was to analyze the attitudes of users to assess whether there were changes in attitudes during the epidemic of the COVID-19 virus, and observed in relation to the period before the epidemic of the COVID-19 virus, which relate to online shopping, to assess the quality of courier services by the respondent, and on the delivery of goods.
Can peripheral blood provide good DNA methylation biomarkers in myelodysplastic syndrome?
Authors: Jorge Joana , Gonçalves Ana Cristina , Cortesão Emília , Pires Ana Cláudia , Alves Raquel , Geraldes Catarina , Pereira Amélia , Ribeiro Letícia , Nascimento-Costa José Manuel , Sarmento-Ribeiro Ana Bela
Published: March 2021

Myelodysplastic syndromes (MDS) are a group of hematological stem cell malignancies strongly associated with aberrant epigenetic anomalies, namely DNA methylation. Blood-based specimens may be a potential source of noninvasive DNA methylation cancer biomarkers. Systemic methylation profile has been explored in solid tumors but is still largely unknown in hematological cancers. We compared DNA methylation status in bone marrow (BM) aspirates and peripheral blood (PB) in MDS patients at diagnosis. Using MS-PCR, we compared DNA methylation status of nine tumor suppressor genes (TSG) P15, P16, TP53, DAPK, MGMT, and TRAIL receptors (TRAIL-DcR1, -DcR2, -DR4, and -DR5) genes. Statistical analysis was performed using the chi-square test, and Kappa statistics analyzed the concordance between BM and PB methylation. Overall survival was assessed by the Kaplan-Meier method. In MDS patients, we observed a high methylation status of the analyzed genes, mainly P15 (64.7%) and DAPK (60.3%). Moreover, 75% of MDS patients presented more than two hypermethylated genes, and these patients had a significantly lower overall survival. We observed a good correlation between gene methylation patterns in PB and BM samples, mainly for P15 (70.6% concordance; kappa = 0.344) and TRAIL-DcR1 (75% concordance; kappa = 0.243). No patient presented TP53 and MGMT methylated genes. Our results suggest that DNA methylation patterns measured in PB may have great potential as informative biomarkers of MDS-related tumor suppressor genes methylation.
SAİT FAİK ABASIYANIK’IN SEMAVER VE MAHALLE KAHVESİ KİTAPLARINDA YER ALAN ÇOCUK TİPLERİ
Authors: ÇİFTÇİ TOMBAL Nazan
Published: March 2021

Modern hikâyeciliğe farklı bir bakış açısı getirmiş olan Sait Faik Abasıyanık, Cumhuriyet dönemi Türk edebiyatının önemli yazarlarından biridir. Hikâyelerinde farklı konu ve tiplere yer veren sanatçı; her zaman ve her yerde karşılaşması mümkün olan balıkçı, işçi, emekçi, hamal, esnaf, memur, işsiz, ev hanımı ya da çocuk gibi sıradan insanları anlatır. Çocuk figürü, sanatçının hikâyelerinin büyük bir kısmında önemli yer tutar. Bazı hikâyelerinde, başkahraman bir çocukken bazı hikâyelerinde çocuk yardımcı karakter olarak karşımıza çıkar. Bu çalışmanın amacı, Sait Faik Abasıyanık’ın Semaver ve Mahalle Kahvesi adlı kitaplarında yer alan hikâyelerdeki çocuk tiplerini incelemektir. Kaynak taramasına dayalı olarak yapılan incelemede, sanatçının bu iki kitabında yer alan ve toplumsal düzenin önemli bir figürü olan çocuk kavramına bakışı değerlendirilmiştir.
Notes on the language of Northern Russian lamentations. 2. Composite nominations, their structure and semantics
Authors: Tolstaya Svetlana M.
Published: March 2021

The paper is devoted to the language of the Northern Russian lamentations collected and published by E.V. Barsov 150 years ago. The author uses the material of wedding lamentations to study the typical folklore language — composite nominations, i.e. nouns, verbs, and other parts of speech formed on the basis of two (rarely three) lexical units: 1) integral compound words (svet-batiushka, drug-podruzhka, zvon-unylyj), 2) phrases with an application (dusha-devushka, doch’-nevol’nica, idti-shatat’s’a), 3) tautological phrases, i.e. complete or partial reduplications (vol’a-vol’ushka, mesto-mestechko, um-razum, gnevev-gneven) or combinations of synonyms (put’-dorozhen’ka, rod-plem’a, znat’-vedat’, gl’adet’-smotret’, strogo-grozno, zhalko-unylo), 4) constructions with a compositional relationship (gusi-lebedi, zlato-serebro, khleb-sol’, kormit’-poit’, dosyta-dop’ana). The classification is based on the following characteristics: structure (the declination of the components of the phrases), macro-syntax (coordination with both members of the binomial or one of them), micro-syntax (relationship of the components with each other—the subordination or composition) and semantics (whether members of the phrase semantically independent, or one of the members serves as an emotional, evaluative, functional definition, addition, refinement, modification of the other). The specifics of folklore material, and particularly of poetic texts of Northern Russian wedding lamentations, are their structural and syntactic diffuseness, blurring of borders between different types of composite units, the tendency to free syntax of the paratactic type, avoiding explicit means of expressing semantic relations (especially subordinates), the predominance of composition over subordination not only in sentences, but also between components of phrases.
Albanian Elements in the Slavic speech of Golo Bordo Bilinguals: Code-Mixing or Borrowing?
Authors: Morozova Maria S.
Published: March 2021

The article considers contact-related phenomena found in the Slavic speech of bilinguals in the multiethnic region of Golo Bordo, Northeastern Albania. Most inhabitants of the Slavic part of the region master the local Western Macedonian dialect and the literary Albanian language. The material for the study includes dialect texts previously published in [Steinke, Ylli 2008; Соболев et al. 2013], examples from [Asenova 2016] and field materials collected by the author. Particular attention is paid to the insertion of Albanian nouns and verbs in the Macedonian speech of bilinguals. The article analyzes the ways to integrate the Albanian nouns, the examples of non-integrated verb insertions, and the models of adaptation of verbs. An attempt is made to provide a theoretical understanding of the described phenomena as either borrowing or code-mixing. The notion of “congruent lexicalization” [Muysken 2000] is used for the interpretation of phenomena such as the insertion of morphologically integrated Albanian nouns and non-integrated verbs used in their Albanian grammatical forms.
Institutions, Hierarchy, and the Flock of the Orthodox Church in the Balkans in the 1600s and 1700s as Shown by New Documents from the Ottoman Archive in Istanbul
Authors: Polyvyannyy Dmitry I.
Published: March 2021

[Rev. of: Mutafova Krasimira, Kalitsin Maria, Andreev Stefan, The Orthodox Structures in the Balkans during the 17th–18th Century according to Documents from the Ottoman Archives in Istanbul, Veliko Tarnovo: Abagar, 2019. 672 p.]

More than two hundred documents from the “Bishops’ files” (Piskopos Kalemi) Collection at Istanbul Ottoman Archives at the Chancellery of the Prime Minister of the Turkish Republic (Başbakanlık Osmanlı Arşivleri), recently published for the first time by Bulgarian scholars of Ottoman Studies Krassimira Mutafova, Maria Kalitsin and Stefan Andreev, reveal multifaceted practices of Orthodox Balkan church institutions’ interactions with the Ottoman authorities from 1684 to 1788. The review deals with the typology of the published documents and the information they contain regarding the fiscal activities of the patriarchy of Constantinople and the patriarchies of Ohrid and Peć (which were incorporated into the Constantinople patriarchy in 1757–1758) towards their Orthodox flock in the Balkan provinces of the Ottoman Empire. The accent is made towards conflicts between the church institutions and the Christian population, as well as contradictions within the higher Orthodox clergy. The importance of personal information on some hierarchs and of data concerning territories and centers of the dioceses is underlined. The author concludes that the reviewed publication provides abundant material for research on the status and functions of the Orthodox hierarchy in the administrative system of the Ottoman Empire in the 17th and 18th centuries.
Holy Martyr Pitirim of Perm: Notes on the Bishop’s Biography and Veneration (15th–16th cc.)
Authors: Tarasov Arkadiy E.
Published: March 2021

The paper deals with three aspects of the biography of the holy martyr Pitirim of Perm († 1455): the place of his original monastic feat, the time and circumstances of the bishop's ordination, and his veneration in the Kirillo-Belozersky monastery after death. The first and third aspects are closely related. According to the author, a number of testimonies of the bishop’s veneration in the Kirillo-Belozersky monastery in the 15th–16th centuries (the presence of his hagiography here, a tradition of records of his martyrdom) may indicate that his tonsure took place in this monastery and confirms the testimony of the Life of the Holy Martyr regarding his teacher, “a certain great elder, Cyril by name”. The veneration of Pitirim of Perm in the Kirillo-Belozersky monastery could have been initiated by Bishop Philotheos of Perm, who retired there. Philotheos was careful to preserve the memory of his predecessors at the episcopal cathedra. Concerning the time and circumstances of Pitirim of Perm's ordination as bishop, the author argues for the authenticity of the dates found in the Vychegod-Vymsky chronicle placing the ordination under 6952 (1443/1444) and his death under 6963 (1454/1455). The bishop’s consecration could have been performed with the participation of Bishop Ephraim of Rostov and Bishop Jonah of Ryazan, and Vladyka (Bishop) Ephraim should have led the consecration. The Life of Pitirim's reference to his consecration by Jonah, who was already a metropolitan, may reflect the need to legitimise the first autocephalous metropolitan during the church crisis of the late 1450s–1460s.
Korelati korištenja medija kod djece predškolske dobi
Authors: Šimić Šašić Slavica , Rodić Marija
Published: March 2021

Cilj istraživanja bio je ispitati povezanost između količine vremena provedenog u korištenju medija djece predškolske dobi i nekih osobnih i okolinskih čimbenika. U istraživanju je sudjelovalo 391 dijete u dobi od 5 do 7 godina. Roditelji su procijenili korištenje medija, temperament i regulaciju emocija kod djece, roditeljska ponašanja prema djetetu i roditeljsku kompetentnost. Odgojiteljice su procijenile socioemocionalnu dobrobit i otpornost djece, a procjene o samopoimanju prikupile su kroz intervjue s djecom. Dobiveni rezultati pokazuju da je količina vremena koju djeca predškolske dobi provode u korištenju medija slabo, ali statistički značajno povezana s osobnim i okolinskim čimbenicima. Spol djeteta, negativan afekt, regulacija emocija, obrazovanje roditelja, popustljivost, informatička pismenost i stav prema dječjem korištenju medija povezani su s djetetovim ukupnim vremenom provedenim u korištenju medija. Korelati vremena provedenog u korištenju medija razlikuju se i ovise o vrsti medija. Rezultati istraživanja ukazuju na potrebu daljnjeg istraživanja uloge medija između varijabli antecedenti i razvojnih ishoda.
THE INVESTIGATION OF THE CONSUMERS’ TOURISM PREFERENCES IN THE COVID-19 PANDEMIC
Authors: ERDOĞAN TARAKÇI İnci , UYSAL Burhanettin , ULUSİNAN Ebrar
Published: March 2021

The new coronavirus (COVID-19) which is rapidly spreading and affecting the whole world, has had significant effects on consumer behavior as in almost every society and industry. Especially, it is expected the fact that the global panic that occurs during the pandemic will impact the tourism sector in this process, change the holiday tourism preferences of the consumers, that consumers will be more selective. The study aims to determine the impact of the COVID-19 pandemic on tourism preferences of the consumers. Within the scope of the research, 403 people were reached with the online survey application and the data were analyzed with the Jamovi (version 1.2.12.0) statistical program. According to the results, the participants think that cleaning/hygiene and health precautions in the facility/area are more important than entertainment and activities in holiday preferences during the COVID-19 pandemic. In the correlation analysis, it was found that there are significant relationships between expressions. The items with the highest relationship are "Infirmary and Medical Services (Doctor) at the Facility" and "Hospitals and Other Medical Institutions in the Region Where the Facility is Located." (r= .764); “Health Precautions Taken for Pandemic in the Facility/Area” and “Cleaning and Hygiene of the Facility” (r= .523).
SILABUS PEMBELAJARAN
Authors: Nensi Fita Novia
Published: March 2021

SILABUS PEMBELAJARAN SMP
Three Proofs that the Square Root of 2 Is Irrational
Authors: Shah Shalin
Published: March 2021

This short article surveys three proofs that √2 is irrational. The first proof is a simple proof by contradiction and the second and third proofs use field theory from abstract algebra.
STX3 is differentially expressed in lymph node metastasis in human breast cancer.
Authors: Mamoor Shahan
Published: March 2021

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). Between the breast and the brain reside the secondary lymphoid organ, the lymph nodes. We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with metastasis to the lymph nodes in humans with metastatic breast cancer. We found that syntaxin 3, STX3, was among the genes whose expression was most different in the lymph node metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. STX3 mRNA was present at decreased quantities in lymph node metastases as compared to primary tumors of the breast. Importantly, expression of STX3 in primary tumors of the breast was correlated with patient distant metastasis-free survival, in lymph node positive patients but not in lymph node negative patients. Modulation of STX3 expression may be relevant to the biology by which tumor cells metastasize from the breast to the lymph nodes and the brain in humans with metastatic breast cancer.
WDR60 is differentially expressed in lymph node metastasis in human breast cancer.
Authors: Mamoor Shahan
Published: March 2021

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). Between the breast and the brain reside the secondary lymphoid organ, the lymph nodes. We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with metastasis to the lymph nodes in humans with metastatic breast cancer. We found that WD repeat domain 60, WDR60, was among the genes whose expression was most different in the lymph node metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. WDR60 mRNA was present at decreased quantities in lymph node metastases as compared to primary tumors of the breast. Importantly, expression of WDR60 in primary tumors of the breast was correlated with patient post-progression survival, in lymph node negative patients but not in lymph node positive patients. Modulation of WDR60 expression may be relevant to the biology by which tumor cells metastasize from the breast to the lymph nodes and the brain in humans with metastatic breast cancer.
STRES PETUGAS KESEHATAN DIMASA PANDEMI COVID-19
Authors: Sembiring Nikita Gina Chesena
Published: March 2021

Covid-19 adalah penyakit menular yang disebabkan oleh jenis virus baru yang belum pernah teridentifikasi pada manusia sebelumnya.Selain berdampak pada kesehatan dan dapat meningkatkan kematian, wabah Covid-19 dapat berdampak pada kesehatan mental atau kesejahteraan psikologis manusia (Othman, 2020). Gejala gangguan psikologis yang paling banyak muncul adalah kecemasan, stress dan depresi (Othman, 2020).Stres dan kecemasan adalah reaksi terhadap situasi yang mengencam dan tak terduga seperti dalam wabah pandemi koronavirus. Petugas kesehatan adalah hal yang paling rentan terhadap hal tersebut. Tenaga kesehatan berisko tinggi mengalami masalah kejiwaan berupa stres ringan hingga berat karena berbagai tekanan yang meningkat dan harus mereka hadapi (Lai Ma, Wang, Cai, Hu, Wei, Wu, Du, Chen, Li, Tan, Kan, Yao, Huang, Wang, Wang, Liu, Hu, 2020).Para profesional perawatan kesehatan, terutama mereka yang berada di garis depan, berisko lebih tinggi terinfeksi, bekerja dibawah tekanan ekstrem, terpapar stres tinggi, waktu kerja yang lama, beban kerja yang berlebihan, kadang-kadang tanpa pelatihan yang tepat dan peralatan perlindungan pribadi yang memadai, dan bahkan kemungkinan lebih didiskriminasi, dan mereka juga menghadapi situasi yang belum pernah terjadi sebelumnya (Greenberg, Docherty, Gnanapragasam, & Wessely, 2020; Kang et al., 2020). Perlunya pendekatan yang akan mendukung perasaan, kekhawatiran tentang kesehatan pribadi, katakutan membawa infeksi dan menularkannya kepada anggota keluarga atau orang lain, diisolasi, perasaan tidak pasti, stigmatisasi sosial, beban kerja yang berlebihan, dan merasa tidak aman ketika memberikan layanan perawatan dan kesehatan pada pasien Covid-19, sebagai dukungan pada mereka yang berada digarda depan dalam merawat dan mengobati pasien.
ANKRD50 is differentially expressed in the lymph node metastases of patients with breast cancer.
Authors: Mamoor Shahan
Published: March 2021

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). Between the breast and the brain reside the secondary lymphoid organ, the lymph nodes. We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with metastasis to the lymph nodes in humans with metastatic breast cancer. We found that ankyrin repeat domain 50, ANKRD50, was among the genes whose expression was most different in the lymph node metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. Analysis of a separate microarray dataset revealed that ANKRD50 was also differentially expressed in brain metastatic tissues (5). ANKRD50 mRNA was present at decreased quantities in lymph node metastases as compared to primary tumors of the breast. Importantly, expression of ANKRD50 in primary tumors of the breast was correlated with patient overall survival, in lymph node positive patients but not in lymph node negative patients.
Hydraulics Lab Manual
Authors: Sarker Shiblu
Published: March 2021

Hydraulics provides a foundation for students who specialize in the field of Water Resources Engineering. This lab manual will deal with application of basic principles of fluids at rest and in motion for analysis and design of hydraulic systems and will provide an advanced understanding of fluid mechanics, open channel flow, pipe flow, water pumps, and some engineering applications of these concepts. This lab manual is the basic laboratory procedure of fluid movement in pipes and open channel. This Lab will implement an active learning laboratory environment to assess students’ understanding and while covering experiments of pipe and open channel flow. Practical engineering problems and design applications will be emphasized.
Imitation and culture: what gives?
Authors: heyes cecilia
Published: March 2021

What is the relationship between imitation and culture? This article charts how definitions of imitation have changed in the last century, distinguishes three senses of “culture” used by contemporary evolutionists (Culture1 – Culture3), and summarises current disagreement about the relationship between imitation and culture. I trace the roots of this disagreement to ambiguities in the distinction between imitation and emulation, and to confusion between two projects that motivate research on cultural evolution – the anthropocentric project and the cultural selection project. Combing out these tangles and highlighting research on neonatal imitation in monkeys and humans, I argue that the relationship between imitation and culture goes both ways. Imitation gives cultural evolution an inheritance mechanism for communicative and gestural skills (but not technological skills), and cultural selection yields the cognitive mechanisms that make imitation possible.
In defense of epicycles: Embracing complexity in psychological explanations
Authors: Endress Ansgar D
Published: March 2021

As simpler scientific theories are widely considered preferable to more convoluted ones, it is plausible (and widely assumed, especially in recent Bayesian models of cognition) that biological learners are also guided by simplicity when acquiring mental representations, and that formal measures of complexity might indicate which learning problems are harder and which ones are easier. However, the history of science suggests that simpler scientific theories are not necessarily more useful if more convoluted ones make calculations easier. Here, I suggest that a similar conclusion applies to mental representations. Using case studies from perception, associative learning, word and rule learning as well as causal inference, I show that formal measures of complexity critically depend on assumptions about the underlying representational and processing primitives, and are generally unrelated to what is actually easy to learn and process in humans. When simpler hypotheses are preferred, they are preferred because they are also easier to process. Empirically viable notions of complexity thus need to build on the representational and processing primitives that are available to actual learners even if this leads to formally complex explanations.