bluuebunny/crossref_metadata_2025 huggingface dataset:
Glymphatic dysfunction and choroid plexus volume increase in older adults with poor sleep quality
Authors: Kikuta Junko
Published: April 2024

Objective
This study aimed to explore alterations in diffusion tensor image analysis along the perivascular space (DTI-ALPS) method and choroid plexus volume (CPV), which could be biomarkers of the glymphatic system in older adults with poor sleep quality (PSQ).
Methods
Fifty-two Japanese older adults with Pittsburgh Sleep Quality Index (PSQI) scores > 5 (22 men and 30 women; mean age ± SD = 73.10 ± 5.67 years) and 52 healthy controls (HCs; PSQI score ≤ 5) were included. Diffusion-weighted imaging (DWI) and 3D T1-weighted images were obtained using 3T magnetic resonance imaging. The ALPS index was calculated using preprocessed diffusion-weighted imaging (DWI), and the CPV was calculated using FreeSurfer 6.0. The mean ALPS index was subsequently compared between the PSQ group and HCs by using a general linear model (GLM) adjusted for covariates, including age, sex, years of education, intracranial volume, systolic blood pressure, diastolic blood pressure, hemoglobin A1c, and white matter lesion volume (WMLV). The CPV was also compared between the two groups by using the GLM, adjusting for the same covariates mentioned above. Next, we conducted a partial correlation analysis between the ALPS index and the CPV, Montreal Cognitive Assessment (MoCA), and PSQI scores, adjusting for all the abovementioned covariates.
Results
Compared with HCs, patients in the PSQ group had a significantly lower mean ALPS (p = 0.04, Cohen’s d = − 0.28) and a greater CPV (p = 0.11, Cohen’s d = 0.24). In the PSQ group, the mean ALPS score was significantly negatively correlated with the CPV (r = − 0.35, false discovery rate [FDR]-corrected p = 0.03) but was significantly positively correlated with the MoCA score (r = 0.35, FDR-corrected p = 0.03).
Conclusion
Older adults with PSQ exhibited a decrease in the glymphatic system and an increase in CPV.
Glymphatic dysfunction and choroid plexus volume increase in older adults with poor sleep quality
Authors: Kikuta Junko , Kamagata Koji , Takabayashi Kaito , Hayakawa Yayoi , Taoka Toshiaki , Saito Yuya , Uchida Wataru , Guo Sen , Yoshida Seina , Yamazaki Keigo , Wada Akihiko , Kaga Hideyoshi , Tamura Yoshifumi , Kawamori Ryuzo , Watada Hirotaka , Aoki Shigeki
Published: April 2024

Objective
This study aimed to explore alterations in diffusion tensor image analysis along the perivascular space (DTI-ALPS) method and choroid plexus volume (CPV), which could be biomarkers of the glymphatic system in older adults with poor sleep quality (PSQ).
Methods
Fifty-two Japanese older adults with Pittsburgh Sleep Quality Index (PSQI) scores > 5 (22 men and 30 women; mean age ± SD = 73.10 ± 5.67 years) and 52 healthy controls (HCs; PSQI score ≤ 5) were included. Diffusion-weighted imaging (DWI) and 3D T1-weighted images were obtained using 3T magnetic resonance imaging. The ALPS index was calculated using preprocessed diffusion-weighted imaging (DWI), and the CPV was calculated using FreeSurfer 6.0. The mean ALPS index was subsequently compared between the PSQ group and HCs by using a general linear model (GLM) adjusted for covariates, including age, sex, years of education, intracranial volume, systolic blood pressure, diastolic blood pressure, hemoglobin A1c, and white matter lesion volume (WMLV). The CPV was also compared between the two groups by using the GLM, adjusting for the same covariates mentioned above. Next, we conducted a partial correlation analysis between the ALPS index and the CPV, Montreal Cognitive Assessment (MoCA), and PSQI scores, adjusting for all the abovementioned covariates.
Results
Compared with HCs, patients in the PSQ group had a significantly lower mean ALPS (p = 0.04, Cohen’s d = − 0.28) and a greater CPV (p = 0.11, Cohen’s d = 0.24). In the PSQ group, the mean ALPS score was significantly negatively correlated with the CPV (r = − 0.35, false discovery rate [FDR]-corrected p = 0.03) but was significantly positively correlated with the MoCA score (r = 0.35, FDR-corrected p = 0.03).
Conclusion
Older adults with PSQ exhibited a decrease in the glymphatic system and an increase in CPV.
Rheological Compatibility of Sulfonated Naphthalene Formaldehyde on Different Mixing Procedures of Activated Slag-based Mixes
Authors: Sengupta Jayashree , Dhang Nirjhar , Deb Arghya
Published: April 2024

This study delves into examining the flow and viscoelastic properties of soda ash and hydrated lime-activated slag mixes with the introduction of sulfonated naphthalene-formaldehyde (SNF) as a superplasticizer. Three different mixing techniques were employed: standard one-part normal-mixing (NM), pre-mixing soda ash in water (PM), and a dry mixture of granulated blast furnace slag (GGBFS) with a NaOH solution (CM). Without SNF, the yield stress followed the order CM < NM < PM. The optimal percentage of SNF varied depending on the mixing technique: 0.75% for NM, 0.5% for PM, and 0.25% for CM. Adding the right amount of SNF reduced the yield stress in all mixing methods. However, it increased the storage modulus, indicating improved structural integrity. None of the samples displayed a distinct low-velocity elastic response (LVER) plateau.
Shared genetic loci between clozapine metabolism and granulocyte counts
Authors: Koch Elise , Parker Nadine , Lock Siobhan K. , Smith Robert L. , Shadrin Alexey A. , Frei Oleksandr , Dale Anders M. , Djurovic Srdjan , Molden Espen , O´Connell Kevin S. , Andreassen Ole A.
Published: April 2024

While clozapine is the most effective antipsychotic drug, its use is limited due to hematological side effects involving reduction of granulocyte counts with potential life-threatening agranulocytosis. It is not yet possible to predict or prevent the risk of agranulocytosis, and the mechanisms are unknown, but likely related to clozapine metabolism. Genome-wide association studies (GWASs) of clozapine metabolism and clozapine-induced agranulocytosis have identified few genetic loci. We used the largest available GWAS summary statistics of clozapine metabolism (clozapine-to-norclozapine ratio) and clozapine-induced agranulocytosis, applying the conditional false discovery rate (condFDR) method to increase power for genetic discovery by conditioning on granulocyte counts variants. To investigate potential causal effects of shared loci, we performed Mendelian Randomization analyses. After conditioning on granulocyte counts, we identified two novel loci associated with clozapine-to-norclozapine ratio. These loci were associated with clozapine metabolism in a validation sample of 392 clozapine-treated individuals. For clozapine-induced agranulocytosis, five loci were identified after conditioning on granulocyte counts. Genetic liability to slow clozapine metabolism (high clozapine-to-norclozapine ratio) showed evidence of a causal effect on reduced neutrophil counts, and genetic liability to low neutrophil counts exhibited weak evidence of a causal effect on clozapine-induced agranulocytosis. Our findings of shared genetic variants associated with clozapine metabolism and granulocyte counts may form the basis for developing prediction models for clozapine-induced agranulocytosis.
Inside the Ryoke Magmatic Arc: Crustal Deformation, High-T Metamorphism, and Magmatic Pulses
Authors: Okudaira Takamoto , Kawakami Tetsuo , Ikeda Takeshi , Skrzypek Etienne
Published: April 2024

The Ryoke belt represents the root of a volcanic arc exposed across SW Japan. It records successive deformation phases, high-temperature metamorphism, and several magmatic pulses that occurred during the Late Cretaceous. Successive magma intrusions at different crustal levels raised the overall geothermal gradient of the arc crust, and their thermal influence was contrastingly recorded in metamorphic zircon and monazite. Despite a broadly similar duration of magmatic activity (20–30 My) along the belt, the timing and periodicity of magma pulses varied. An along-arc variation in lower crustal magma generation together with a fluctuating crustal stress regime likely controlled the formation and evolution of this magmatic arc section.
STUDY ON MECHANICAL AND THERMAL PROPERTIES OF WATER HYACINTH CEMENT COMPOSITES
Authors:   Associate Professor, Department of Civil Engineering, Sethu Institute of Technology, Kariapatti - 626 115, Virudhunagar District, Tamilnadu, India., Karthik A. , Chandru Maris K. Rooban ,   Final Year Civil Engineering Student, Department of Civil Engineering, Sethu Institute of Technology, Kariapatti - 626 115, Virudhunagar District, Tamilnadu, India., R. Suligaikumar ,   Final Year Civil Engineering Student, Department of Civil Engineering, Sethu Institute of Technology, Kariapatti - 626 115, Virudhunagar District, Tamilnadu, India., K. Vishnu ,   Final Year Civil Engineering Student, Department of Civil Engineering, Sethu Institute of Technology, Kariapatti - 626 115, Virudhunagar District, Tamilnadu, India., S. Vishwa ,   Final Year Civil Engineering Student, Department of Civil Engineering, Sethu Institute of Technology, Kariapatti - 626 115, Virudhunagar District, Tamilnadu, India.
Published: April 2024

This study investigates the mechanical and thermal properties of a novel cement composite incorporating water hyacinth, an abundant and under-utilized aquatic plant. The water hyacinth fibers were treated and mixed with cement to create a composite material. Various ratios of water hyacinth to cement were tested to optimize the composites properties. The mechanical properties, including compressive strength, tensile strength and flexural strength were evaluated using standard testing methods. The thermal properties were assessed by measuring the thermal conductivity and specific heat capacity of the water hyacinth cement composites. The test results indicate that the water hyacinth cement composite exhibits promising mechanical strength and improved thermal insulation compared to conventional cement. This research suggests that water hyacinth, often considered a problematic invasive species, could be effectively utilized in sustainable construction materials.
INTERSTELLAR EXTINCTION MODELLING BY AGGREGATE DUST
Authors:   Kokrajhar Govt. College, Kokrajhar, Assam, India., Bhattacharjee Chinmoy
Published: April 2024

Extinction generally ours whenever electromagnetic radiation propagates through a medium containing small particles. The spectral dependence of extinction, or extinction curve, is a function of the composition, structure and size distribution of the particles. The study of interstellar extinction is important because they provide essential information for understanding the properties of the dust. In this work we have considered the aggregate dust model to interpret the extinction efficiency (Qext) of interstellar dust in the wavelength range 0.11Âµm to 3.4Âµm. Using Superposition T-matrix code with Ballistic Cluster-Cluster Aggregate (BCCA) aggregate having 64 number of monomers with graphite, astronomical silicates and amorphous carbon, the normalized extinction efficiency has been calculated for a well designed size distribution within a size range 0.001 to 0.077 micron of extinction near wavelength 0.2175Âµm. It is seen that for large grain size distribution the well pronounced UV-bump almost disappear. Moreover the nature of variation of extinction curve with increasing size of the grain has also been shown.
PRICING OF EQUITY INVESTMENT - AN EMPIRICAL ANALYSIS OF INDIAN CAPITAL MARKET
Authors:   Director, Progressive Investment Pvt Ltd., Patil Rahul
Published: April 2024

The investment is stock market is an art as well as science. The objective of stock market investment is to achieve superior returns comparing other investment options. The investment cost is one of the variable contributing towards the performance of the stock. The justified price of the stock is always a matter of discussion but no specific formula or theory exist to recognize the correct price. This paper is an attempt to decompose the market price of the stock listed on Indian exchanges. Using the data for 10 years, explanatory variables are identified which explain market price of the stock. The model identify the significant factors explaining 62 per cent changes in the market price. The findings of the study are useful to all academicians, researchers and market participants to understand the complex dynamics of market price of the stock and its explanatory factors.
Identification of Adulterants in Extra Virgin Olive Oil Using HS-SPME-GC-MS and Multivariate Data Analysis
Authors: Knaul Luana , Santos Leticia Maria , Ramos Priscila Maria , Cabrera Martha , Rüdiger André Luis , Kapp Marcelo , Toci Aline , Boroski Marcela
Published: April 2024

Food fraud, such as the adulteration of extra virgin olive oil (EVOO), is found to cause substantial negative impacts on both the economy and the health of consumers. This work was aimed at evaluating 19 EVOO samples commercialized in Foz do Iguaçu, a frontier city located around the triple border of Brazil, Argentina, and Paraguay. To detect the presence of adulteration in EVOO samples, the present study employed gas chromatography coupled to flame ionization detector (GC-FID) and headspace solid phase microextraction with gas chromatography coupled to mass spectrometry (HS-SPME-GC-MS) in order to evaluate fatty acids composition and volatile organic compounds (VOCs), respectively. The quantitative results obtained from the analysis of fatty acids composition showed that 32% of the EVOO samples were adulterated, presumably with soy oil, due to the high levels of linoleic, linolenic, and myristic acids present in them. Principal component analysis (PCA) conducted using the complete chromatographic aroma profiles obtained from the VOCs helped distinguish authentic EVOO samples from adulterated ones and the country of origin of the samples. The following aromatic compounds were first described, as possible adulterant markers: 3,3-dimethylheptanoic acid, propyl pentanoate, methyl cyclohexanecarboxylate, ethyl cyclohexanecarboxylate, 2-phenylethyl acetate, 6,10,14-trimethylpentadecan-2-one, and 1,2-dimethoxy-4-methylbenzene.
Comparative study between Patrangasava and Pradararipu Rasa in the treatment of Leucorrhoea
Authors: Animesh Maiti
Published: April 2024

Leucorrhoea is a common and significant issue that affects women, particularly during their reproductive years, often experiencing it at least once. It manifests as a discharge of white fluid from the vagina. In this study, we evaluated the comparative efficacy of Patrangasava and Pradararipu Rasa in treating Leucorrhoea. Sixty patients with clinical symptoms including white vaginal discharge, vulva itching, vaginal burning pain, low back pain, and general weakness were selected and divided into two equal groups: Group A and Group B. Group A received treatment with Patrangasava for 3 months, while Group B received treatment with Pradararipu Rasa for the same duration. This prospective, comparative, observational study aimed to assess the effectiveness of these treatments in both groups. The study observed a significant reduction in mean scores of clinical symptoms, particularly white vaginal discharge, in both groups. Overall compliance with the treatment was good in both groups, with a highly significant p-value of < 0.001.
Pharmaceutico-Analytical Study of Kaidaryadi Ghanavati - A Poly Herbal Formulation
Authors: Rohini HD  , Prashanth AS
Published: April 2024

Kaidaryadi Kashayam is an herbal preparation which is commonly used in Udaragata Vikaras like Pravahika, Agnimandhya and Grahani etc. Even though this Yoga is used most frequently used and having only four easily available ingredients very less companies are preparing the Kashaya. The excellent results are seen in the Grahani, Pravahika etc diseases conditions. The palatability is a challenge for taking the Kashya and also transportation is a challenge. In the present study here attempt has been made to prepare Ghanavati of Kaidaryadi Kashaya of Chikitsa Manjari text book by Rasakriya method. The prepared Vati was subjected for physciochemical and phytochemical analysis, HPTLC, microbial load as per the WHO guidelines. Efforts were made to set the analytical standards for the Kaidaryadi Ghanavati which were not reported till date. Loss on drying - 10.084%, Ash value -13.366%, Acid insoluble ash - 1.287%, Water soluble extractive - 79.793%, Alcohol soluble extractive -4.064%, Hardness - 10kg/cm, Friability - 0.004%, Disintegration - 20min, pH - 5.23, in HPTLC of Kaidaryadi Ghanavati maximum four spots at short UV and maximum seven spots long UV. Microorganisms in the formulation were found to be 24CFU/ml.
Nephroprotective activity of Bilwadi Agada in Cypermethrin Induced Nephrotoxicity in Wistar Rats
Authors: Neeraj A.K  , U. N. Prasad  , Swapna Swayamprabha  , Sudhakar Bhat
Published: April 2024

Introduction: One of the most potent and widely used formulations of Agadatantra is Bilwadi Agada mentioned in the context of management of envenomation from snake in Ayurveda. The same formulation is also indicated in multiple ailments like poisoning from other animals or insects and even is general conditions of fever. Nephroprotective activity has been demonstrated by Bilwadi Agada and the same was evaluated in this experiment in Wistar rats induced by cypermethrin Aim: To evaluate the nephroprotective activity of Bilwadi Agada in toxicity induced by cypermethrin in wistar albino rats. Materials and Methods: According to OECD guidelines 407, the induction of sub‑acute toxicity was done and effect of Bilwadi Agada was evaluated in wistar albino rats. Results: Degenerative changes in kidneys were found to be increased in lower dose level but moderate reversal was observed in higher dose. Conclusion: The thorough analysis of the results shows that the test drug at double the therapeutic dose causes moderate reversal of toxicant induced changes, thereby providing evidence for presence of nephroprotective activity against cypermethrin toxicity. Thus, therapeutic effects of Bilwadi Agada along with suitable cytoprotectant will be beneficial in the management of Cypermethrin toxicity.
Pharmaceutical-Analytical Study and Therapeutic uses of Ashtashatarishta : A Scientific View
Authors: Raju Ninama  , Archana Verma  , Anil Nagle  , R K Pati
Published: April 2024

Background: Ashtashatarishta comes under the Sandhan Kalpanas quoted by Charak Samhita, Chikitsa Sthan for therapeutic use in Shotha. Aim and Objectives: Pharmaceutico-Analytical and clinical indications of Ashtashatrishta from a scientific view. Material and Methods: Ashtashatarishta was prepared in the Department of Rasashasra and Bhaishajya Kalpana of Pt. K. L. S. Govt. Ayurveda College & Institute Bhopal. As per the classical reference of Charak Samhita. Pharmaceutical study: A detailed description of the preparation of Ashtashatarishta by using yeast as a fermentation agent is discussed in this part. The sample was prepared in a Pharmacy of Dept. of Rasa Shastra & Bhaishajya Kalpana. Analytical study: In this phase of the study, all organoleptic parameters (appearance, color, odor, taste, and touch), and physicochemical parameters were analysed. Result: The above analysis showed the pH of the tested formulation range 3.47, total solid content 29.93%W/v, specific gravity 1.0595, refractive index 1.391, viscosity 2.20cP, total acidity 1.26%W/v, alcohol content 4.27%v/v, presence of methanol absent, reducing sugar 17.37%W/v, non-reducing sugar 8.675W/v. Organoleptic tests confirmed a characteristic odor of self-generated alcohol with an astringent test. Discussion: All the observations and results of the pharmaceutical and analytical study have been elaborated and discussed scientifically with the support of suitable references.
Neutraceutical and Pharmaceutical Potential of Fagopyrum esculentum (Linn.) Moench.
Authors: Kaur Taranjeet  , Mishra H.S.  , Agarwal A.K.  , Bedar S.S.
Published: April 2024

Buckwheat is a gluten-free pseudocereal grown annually in hilly regions of India. It belongs to family Polygonaceae and genus Fagopyrum. Buckwheat is adaptable to extreme cold temperature, stress conditions of water making it a sustainable crop. In India, twenty species of buckwheat are cultivated across various hilly regions. Out of these only nine species have desirable nutritional value and two are commonly grown. They are Fagopyrum esculentum (Common buckwheat) and Fagopyrum tartaricum (Tartary buckwheat). Buckwheat has good amount of nutrients and many health benefits. Buckwheat has been used in the gluten free diet for those suffering from celiac disease. It can be used for the prevention of obesity and diabetes as they have high total dietary fibre and soluble dietary fibre. It is commonly used grain in the name of Kuttu in Indian society during fasting. The present study aims at establishing the Neutraceutical and Pharmaceutical utility of potential alternative to conventional food grains as mentioned in the contemporary texts.
An analytical study on Sharad Ritucharya
Authors: Vinod Bajiya  , Pramod Kumar Mishra  , Brahmanand Sharma
Published: April 2024

The newly emerging diseases and diminishing immunity have made humans to seriously think about their health. Lifestyle modulation and adaptation according to climate is the need of hour. The glorious Ayurveda has its principal focus of conserving health and prevention of disease before their occurrence.[1] Aacharya’s have described Dincharya (daily regimen) and Ritucharya (seasonal regimen). One can cherish good health by following proper Ritucharya, described in classical texts of Ayurveda. The living beings especially humans are hugely affected by the change in climate. The features of all the Ritus, dietary and habitual modulation according to changing Ritu has been widely explained in the foremost texts of Ayurveda. Here, the Sharad Ritu which is one of the Ritu’s of Dakshinayan is overviewed so as to present the dietary and behavioural regimen in this season. The Sharad Ritu marks the transition from summers to winters. The hot sun rays in Sharad Ritu exaggerate the Pitta Dosha which is already accumulated in body in the Varsha Ritu. So dietary and habitual modifications which are Pitta Shamak in nature should be followed in Sharad Ritu along with the Shodhan procedures like Virechan and Raktamokshan.
A clinical study to evaluate the efficacy of Aaditya Pak Guduchi Tail Shiroabhyanga in management of Khalitya (Baldness)
Authors: Ghayan Kanwar  , Pramod Kumar Mishra  , Brahmanand Sharma
Published: April 2024

Introduction: In today’s corporate life, prime importance is given to our appearance, personality and beauty. Hair plays an important role in making body externally beautiful, healthy and good looking. Long hair makes a person mentally enthusiastic and healthy. Who are mostly suffering from this problem is the total population. Susceptibility of hair fall is more in male than in females. Methodology: Present study is carried out to know the traditional Ayurvedic treatment for Khalitya. For Khalitya Shiroabhyanga is one of the best choices of management for its prime role in maintaining hair growth and preventing Khalitya. Massage (Abhyanga) greatly improves the blood circulation, thus increasing the health of hair and also scalp. Result: The present study showed significant reduction in hair fall, dryness. Aaditya Pak Guduchi Tail was found effective in Khalitya along with significant effect on associated complaints. Conclusion: It also proves that Aaditya Pak Guduchi Tail is effective for use as Shiroabhyanga along with local application for scalp and hairs.
Conceptual study of Vata Dosha w.s.r. to Nervous System
Authors: Tarkeshwar Sharma  , Chetan Ram Meghwal  , Monika Prajapat  , Ashok Kumar Sharma
Published: April 2024

The depth of Ayurvedic principles must be understood and emphasized in a clear, simple manner in light of the growing awareness of Ayurveda and its importance in today's society. Despite the rapid advancement of modern science and the plethora of new medical research projects, it would not be hyperbole to argue that Ayurveda has already established its distinct identity and has been steadily advancing with new insights. Doshas stand for the presence of Pancha Maha Bhuta in our bodies, Panchamahabhuta is the foundation upon which all Ayurvedic concepts are based, and Panchabhutika refers to everything in the universe. The management of Panchamahabhutas, for which the Ayurvedic approach is essential, determines the course of treatment, regardless of advancements in modern science. One of the three basic humors, Vata, has a significant impact on both health and disease. The majority of Vata disorders that are discussed in Ayurveda are classified as neurological disorders in contemporary medicine. As a result, an effort has been made to comprehend Vata physiological activity, paying particular attention to neurophysiology.
Importance of Achara Rasayana in Present Era
Authors: Rajeev Kumar  , Ujjwal  , Sanjiv  Kumar  , Guru Sharan Pal  , Vijay Shankar Pandey
Published: April 2024

There is a crisis of character in all fields or professions. Some persons in almost all professions are corrupt, making failure of the system. Many efforts have been done by the government in many countries to improve the system but complete removal of corruption could not be done because ethical or moral values cannot be forced. Public should be self-conscious about morality. Achara Rasayana (Ethical Alchemy) is a special contribution of Acharya Charak for achieving the physical, mental and social health and a high moral sense. The individuals acquire rejuvenation effects, who are truthful and free from annoy, devoid of alcohol and sex indulgence, do not involve in fighting or exhaustion, nonviolent and pleasant on their language, carry out Japa and hygiene, Dhira individual, frequently carry out charity and Tapas, frequently offer prayer to the God, cows, Brahmanas, teachers, preceptors and old persons, completely free from barbarous acts, sympathetic, time of awakening and sleep are regular, routinely receive milk and ghee, aware with the nation and the time, experts in the knowledge of rationality, free from self-image, have good behavior not narrow minded, have love for religious information, have brilliant sense organs, have respect for seniors, Astikas the existence of God and validity of the Vedas, having self-control and commonly study scriptures. Thus, Ayurvedic literature shows many matchless information of primary importance in context of Rasayana.
Intervention of IT in Rog Nidan Evum Vikriti Vigyan - An Explorative Review
Authors: Nimisha Mishra  , Prof. Satya Deo Pandey
Published: April 2024

Introduction: Going by the trend, the Indian traditional medicine system Ayurveda is observing a paradigm shift in its growth, and in the era of technology AI (Artificial Intelligence) is one of the main factors behind it. Be it the discovery of new medicines, implementation of a new drug discovery model, getting its global acceptance through patents, or the delivery of the final product through AI equipped supply chain model system, the intervention of technology cannot be ruled out. Methodology: The literature survey was done through Google Scholar database, PubMed, and Web of Science. The dig out information about the use of IT in Medical fields and, use of technology in Ayurveda were screened for relevant studies synthesis. Result: At last, we have sorted out the areas of Rog-Nidan that need to be taken care of from a research point of view with the help of information technology. Discussion:  In this research paper, an effort has been made to review the areas where technology can play its role, especially in Rog-Nidan. Additionally, the approaches that are being used in Ayurveda where it is being presented as wellness therapy and preventive care have been studied along with identifying the gaps that can be addressed with efficient use of IT-based technologies.
Role of Ayurveda in Graceful Ageing w.s.r. to Dincharya, Ratricharya & Ritucharya
Authors: Varun Maithani  , Tanvi Gusain
Published: April 2024

Background: In present time, looking young is something which is needed by everyone. The beauty standards have been definitely increased which certainly only amount to external beauty. The market of the cosmetic industry has grown a lot in the past year because of the increased consumer which is definitely not gender oriented. Aim: To demonstrate the role of ayurveda with special reference to ageing. Objective: To study the importance of Dincharya, Ritucharya & Ratricharya. Material & methods: The material will be collected from the Bruhatrayee & Laghutrayeesamhita. And any scientific studies related with above will be obtained from the google scholar, pubmed or any other online source. Discussion: Acharya has mentioned the importance of Dincharya, Ritucharya in the Samhitas. There is a specific criterion which is to be followed in accordance to Dincharya, Ritucharya & Ratricharya because of the distribution of Tridoshas accordingly. Conclusion: Looking young with great skin even at old age doesn’t define being young. People need to change their perspective on how they look at ageing. And that’s where the regime of ayurveda can help in ageing gracefully the one where everyone is disease free physically, mentally & emotionally and cover all the aspect of being ‘Swastha’. Only healthy eating doesn’t define our health. There are other factors described well in the ayurveda to create a balance in Dosha. Dincharya, Ratricharya & Ritucharya play an important role in maintaining Swasthya by controlling the external factors which are equally important for internal dosha balance & thus longevity in long run.
Concept of Deshaviparyaya w.s.r. to Migration - A Literary Review
Authors: Gouri M. Wariyar  , Arhanth Kumar K  , Vidyalakshmi K
Published: April 2024

Desha (geographical distribution) is one of the important principles linked with health of individual. The characteristics of the Desha impart certain physical, physiological, psychological attributes in inhabitants. There is another term Deshaviparyaya which is not much understood. This factor is one main cause for many diseases prevailing nowadays. A comprehensive exploration can be done between Deshaviparyaya and migration. Through a multidisciplinary lens, this work aims to provide insights into complex interplay between geographical disorientation and health effects on people’s health. Aims  & Objectives: Literary review on basic concepts of Desha & Satmya (Habituation) & understanding concepts of Deshaviparyaya in view of migration. Materials & Methods: Ayurvedic literatures containing all details about Desha, Satmya & Deshaviparyaya were studied and literary material was critically reviewed. Discussion: Effect of migration and on sleep, integumentary system and generation of stress has been discussed with its Ayurvedic treatment. Conclusion: Migration has impact on different systems of human body. This article can be hypothesized that Desha & Satmya should be considered for successful administration of therapeutics.
A review on Janusandhigata Vata
Authors: Swetha BM  , Madhusudhan Kulkarni  , Yaseen Hullur
Published: April 2024

Janusandhigata Vata is explained in concise form in our Samhitha. The symptoms includes Vatapoorna-Dritisparsha, Sandhi Shotha, Prasarana Acuchanayo Vedana, Atopa, Sandhi Hanti. Various treatment modalities have been employed such as Bahya and Abhyantara Snehana, Basti Prayoga, Upanaha, Agnikarma, Bandhana, Unmardana. Aetiology and symptomology of Sandhigata Vata mentioned in Samhitha, mimics with the symptoms of osteoarthritis of contemporary science. Osteoarthritis is defined as a non-inflammatory degenerative joint disease marked by degeneration of articular cartilage, accompanied by pain and stiffness of joints. When left untreated this disease makes the person crippled and dependent on others for attending normal daily activities.
Unlocking Fertility - with administration of Lekhaniya Mahakashaya in Pushpaghani Jataharini w.s.r. to PCOD
Authors: Arti Yadav  , Sucheta Ray  , Aswathy K  , Ekta Singh Parihar  , Priyanka Hajare
Published: April 2024

Children are a gift from the Lord; the fruit of the womb is a divine reward. Average Reproductive Age is 14-49 yrs. This age group have number of conditions related to menstrual cycle, such as Menorrhagia, Dysmenorrhea, Irregular menses, PCOD, endometriosis, etc. According to WHO - PCOD is a lifestyle disorder which is a common hormonal condition that affects women of reproductive age. It usually starts during adolescence, but symptoms may fluctuate over time. PCOD can cause hormonal imbalances, irregular periods, excess androgen levels and cysts in the ovaries, absence of menstruation, excessive hair growth (face, body, including back, belly and chest), acne, weight gain, hair loss, skin darkening (in neck and groin). Irregular periods, usually with a lack of ovulation, can lead infertility. PCOD is a leading cause of infertility. PCOD can lead to anovulation where ovaries stop releasing eggs. PCOD is a common condition that causes 70% of anovulation cases. PCOD causes the excessive production of androgens, which cause the follicles in your ovaries to remain small instead of maturing and growing as they have to prepare for ovulation. In Ayurveda on the basis of symptoms Pushpaghani Jataharini can be correlated with PCOD. PCOD is a chronic condition and cannot be cured. However, some symptoms can be improved through lifestyle changes and medications. In order to treat PCOD the changes in the life style and the administrations of Ausadhies like Lekhaniya Mahakashaya (Musta, Kustha, Haridra, Daruharidra, Vacha, Ativisha, Katurohini, Chitrak, Chirbilva).
Critical appraisal of Millets - A Conceptual Study
Authors: Deeksha Dubey  , Trupti Jain  , Nitin Marwaha
Published: April 2024

Recently the millets have been recognised with their enormous potential and they are renovate as Nutri-cereals (shree anna). Millets are good source of protein, vitamins, and minerals like phosphorus, calcium, magnesium, iron etc. As millets are loaded with phytochemicals, they help in management of various life style disorders like cardiovascular disease, obesity, diabetes mellitus, cancer. Millets are one of the oldest staples for various civilisation across the continents. In Ayurveda literature they are explained under the Dhanya Varga as Trindhanya, Kudhanya and Kshudradhanya. General properties of millets are Ushna Veerya, Kashaya and Madhura Rasa, Katu Vipaka, Laghu and Ruksha Guna. But beyond these, some specific properties have also been mentioned in detail in Ayurveda Classics. In Ayurveda literature millets have been described as Pathya-Apathya in various diseases. Present paper encompasses various aspect of Millets described in Ayurveda and contemporary science so that the importance of millets is known to each and every person.
Ayurvedic management of Nasa Arsha w.s.r. to Nasal Polyp - A Single Case Study
Authors: Poonam Devi  , Ashu  , Manoj Kumar
Published: April 2024

Arshas is described as one of the Asta Mahagada Roga by Acharyas and is also explained as a fourfold treatment such as Bheshaja, Shastra, Kshara and Agni Karma. The Nasa Arshas means Arshas located in the nasal cavity causing nasal obstruction. The predominant Dosha is Kapha and Dushya is Twak, Mamsa and Medho Dhatus. Nasa Arshas can be correlated with nasal polyps. Nasal polyps are non-neoplastic masses of oedematous, prolapsed, pendenculated nasal or sinus mucosa. It can be treated by medical and surgical methods. Prolonged usage of anti-histaminics, steroids, antibiotics, nasal decongestants cause drug resistance, decreases the immunity, rebound congestion and there is a lot of chance for reoccurrence, even after the surgery especially in ethmoidal polyp. In Ayurveda, several treatment modalities have been planned for the treatment of Arsha as Shastra Karma (operative procedure), Kshara Karma (applying some alkaline drugs), Agni Karma (cauterization) and Bhaishaja (conservative/medical treatment). Here the present case study was planned to evaluate the efficacy of Anu Taila Nasya with Shamanaoushadhas.
Effect of Nimbadi Taila Vrana Basti in the management of Dusta Vrana (Chronic Ulcer) - A Case Study
Authors: Nikhil Sood  , Jeetendra A. Javali  , B.S. Savadi
Published: April 2024

Dusta Vrana (chronic ulcer) is a frequently encountered problem in present era produced commonly as a complication of trauma or pathologic affront and it causes long term agony to the patient. The issue of chronic ulcers management with Ayurvedic panacea is one of the major areas of research and has come under increased scrutiny. In the present study Nimbadi Taila is selected which is cited by Acharya Bhela in the context of Vrana. It contains Nimba Pallava, Aamra Pallava, Amalaki Pallava, Bala, Yashtimadhu and Gomaya Rasa. These drugs possess Vrana Shodhana and Ropana properties. It was used in Vrana Basti in the management of chronic ulcer for 7 days followed by dressing with Nimbadi Taila. It reduces pain, burning sensation, itching, reduces discharge, oedema, and helps in gradual improvement in floor and granulation tissues. Hence it can be speculated that Nimbadi Taila possess sufficient efficacy in Vrana Shodhana and Ropana without producing any adverse effects.
A Survey for - Awareness about Dinacharya in General Public
Authors: Sunita Pandey  , Sanjiv Kumar  , Rajiv Kumar  , Prabhat Kumar Dwivedi
Published: April 2024

Dinacharya is a concept from Ayurveda, the traditional system of medicine in India. In Sanskrit term, Dinacharya, translates into daily routine or "daily regimen." It refers to daily routines and practices that are believed to promote overall health and well-being. These routines are designed to align with natural circadian rhythms and include activities such awaking up early, oral care, bowel movement, hygiene practices, exercise, dietary habits, meditation and mindfulness, work and rest and seasonal adaptation. Ayurveda places a strong emphasis on preventive healthcare and maintaining a balance of the body, mind and spirit to promote overall well-being. The main aim of this work is to know how aware is the public? This survey assesses public awareness, revealing that urban populations are more informed about Dinacharya than rural ones. It is important to note that individual variations exist and Ayurveda recognizes the uniqueness of each person's constitution, known as Prakriti, Doshas etc.
Phytochemical investigation and experimental evaluation of Panchavalkala for Lekhana Karma w.s.r. to Antihyperlipedemic Activity
Authors: Raghunath G.V  , M.S Veena  , Suresh Janadri
Published: April 2024

Panchavalkala the barks of five trees i.e., Nyagrodha (Ficus benghalensis L.), Udumbara (Ficus racemosa L.), Ashwatha (Ficus religiosa L.), Plaksha (Ficus virens Aiton) and Parisha (Thespesia populnea (L.)Sol.ex Correa) are also known as Pancha Ksheeri Vrikshas in use since Vedic period. The plant samples were collected in Sharad Rutu (late autumn) from their natural habitat, extracted using ethanol and water and subjected for the phytochemical analysis. The study was aimed to evaluate Antihyperlipidemic effect (Lekhana Karma) of Panchavalkala Bark extracts individually and in combination (1:1:1:1:1) both in ethanolic and aqueous extracts on serum lipid profile in Cafeteria died (HFD) induced hyperlipidemia in SD rats. The animals were divided into fifteen groups of six animals each. The normal control group continued to be fed laboratory pellet chow ad libitum. The cafeteria diet-control group received the cafeteria diet in addition to the normal pellet diet (NPD). The remaining 13 groups were fed with the cafeteria diet and NPD along with standard control Atorvastatin 10mg/kg and the test drug p.o for 30 days. Treatment with the test substance PVK AE and PVK EE at doses of 200mg/kg body weight p.o. controlled and regulated the HFD induced weight gain, glucose and lipids in the blood when compared against high fat diet control (P< 0.05). PVK bark extracts are capable of exhibiting significant antihyperlipidemic activity in HFD induced SD rats. Taken together, this study strongly suggests that PVK bark extracts might be an efficient way for treatment of hyperlipidemia.
Avaliação experimental de tensões geradas num sistema de colagem de cerâmica sob ação de gradientes térmicos
Authors: Silva L. , Sequeira P. , Flores A. , Viriato N. , Melo F.Q. , Vaz M. A.
Published: April 2024

O sucesso da aplicação de cerâmica em fachadas e pavimentos exteriores depende, entre vários fatores, de uma correta relação e compatibilidade mecânica, química e física entre os todos os elementos envolvidos, a saber, o suporte, a cerâmica e as argamassas. Quando exposto a variação térmica, fatores como a dimensão e cor dos cerâmicos, tipologia do suporte e dimensão de junta adotada, assumem especial relevância ao nível das tensões obtidas. Um estudo recentemente publicado avalia as tensões geradas em contexto de aplicação com suportes como: reboco, betão ou um isolante térmico, apresentando exaustivamente resultados de combinações de vários elementos do sistema. Tais elementos parecem adequar-se e comprovar as exigências em contexto real, sublinhando a importância de se caracterizar experimentalmente alguns casos, como método de validação dos resultados obtidos em simulação numérica. O presente trabalho aborda este desafio ao definir e executar uma metodologia experimental que permite obter as tensões em diferentes componentes, por ação de um gradiente térmico sobre um sistema cerâmico colado em condições próximas dos modelos teóricos. Admite-se que a comparação de resultados obtidos permitirá fazer uma reflexão ao grau de aplicabilidade da metodologia teórica desenvolvida e eventuais necessidades de afinação da mesma.
Melhoria de desempenho do ETICS, com base em lã mineral, por homogeneização da superfície de interação entre componentes
Authors: Cardoso D. , Flores-Colen I. , Pereira M. F. C. , Ferreira P. , Sequeira P. , Silva L.
Published: April 2024

A solução de isolamento térmico pelo exterior (ETICS) é reconhecida no mercado como solução de excelência no revestimento de fachadas, por prover conforto térmico, otimização de consumo energético e pelo próprio desempenho mecânico e estético, com vantagens inerentes. Porém, apresenta algumas limitações, uma das quais relacionadas com a reação ao fogo que, em parte, é melhorada pela utilização de materiais isolantes de base mineral, como a lã de vidro. Face a esta conjetura, admite-se um número crescente, mas ainda limitado na totalidade de ETICS, de casos com utilização deste material como isolante. Esta experiência crescente permite, por outro lado, conhecer fatores mais críticos na aplicação e sucesso deste sistema em específico, sendo um deles relacionado com casos de observação de falta de aderência em pontos aleatórios da fachada. Este estudo elabora e apresenta uma metodologia de trabalho que tenciona apresentar a causa para a anomalia e uma proposta de minimização ou eliminação da mesma, e que assenta na hipótese de otimização por homogeneização de absorção da superfície da placa isolante.
Micro-indicadores de Circularidade para o Setor de Construção Civil na Perspetiva de Produtos Plásticos
Authors: Matos J. , Martins C.I. , Simões C.L. , Simões R.
Published: April 2024

O setor da Construção Civil é um dos maiores contribuintes da atualidade para o aumento continuo no consumo global dos plásticos. No entanto, apesar das propriedades dos plásticos se adequar a várias aplicações neste setor, a sua sustentabilidade é uma preocupação, principalmente porque as aplicações plásticas atuais são projetadas e fabricadas sem uma prudente reflexão sobre o seu ciclo de vida e a sua gestão em fim de vida. Este fator, impulsionado pelo crescimento global da população e aumento na procura por habitação, juntamente com um comportamento social irresponsável com a gestão dos resíduos de construção e demolição, resultou num agravamento da crise global de poluição ambiental. A maioria do plástico reciclado que entra atualmente no mercado europeu é aplicado na construção civil em aplicações não ecológicas, que simplesmente consomem recursos plásticos. É vital preservar e otimizar os recursos existentes, o que requer empregar conceitos e estratégias da economia circular e, para isso, é preciso medir a circularidade de um produto. Os indicadores de circularidade são muito interessantes nesta abordagem. No entanto, existe uma infinidade destas ferramentas na literatura, com características e metodologias incompatíveis. Este artigo fornece uma análise dos micro-indicadores de circularidade mais relevantes para o setor da Construção Civil, enquanto identifica diretrizes e boas práticas para promover a transição do setor para uma economia mais circular.
Thrombotic Microangiopathy in Solid Organ Transplantation
Authors: Nandavaram Sravanthi , Twist Hannah , Evans Rickey , Paluri Sravanthi , Castellanos Ana , Pelaez Andres
Published: April 2024

Thrombotic Microangiopathy (TMA) is a syndrome characterized by microangiopathic hemolytic anemia (MAHA) and thrombocytopenia. The presence of schistocytes on peripheral smear, a negative Coombs test, elevated lactate dehydrogenase, increased reticulocyte count and low haptoglobin are often the clues for MAHA. The microvascular process often targets vasculature in kidneys, brain, gastrointestinal system, heart, and skin. A timely diagnosis and treatment are often crucial to prevent severe end organ damage and death. TMA is classified into primary and secondary forms. Primary TMA includes TTP and complement mediated or atypical hemolytic uremic syndrome (aHUS), often related to a mutation or deficiency and clinically expressed in the setting of a precipitant condition. Secondary TMA is a manifestation of underlying disorder and can occur in clinical scenarios associated with autoimmune disease, malignancy, infections, SOT (Solid Organ Transplant), pregnancy, HSCT (Hematopoietic Stem Cell Transplantation), medications, or methylmalonic acidemia. Transplant associated TMA (TA-TMA) can be complement mediated or aHUS and could be related to the ischemic reperfusion injury, induction regimen, calcineurin inhibitor (CNI) use, mammalian target of rapamycin (MTOR) inhibitor use, or could be infection related. Cost, access, and turnaround time are often the limitations for certain TTP and complement specific testing. Treatment should not be delayed while waiting for such tests. Treatment must be individualized based on the underlying cause of TMA. Terminal complement blockade utilizing monoclonal antibodies directed against C5 complement is the treatment for complement mediated TMA. C5 inhibitors have also been used successfully in treatment of secondary HUS cases where, unlike aHUS, defects in complement cannot be demonstrated. Such treatment has demonstrated improvement in renal function, MAHA and platelet counts.