bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Spindle Speed and Feed Rate on Surface Roughness and Milling Duration in Fabrication of the Milled Complete Dentures: An In Vitro Study
Authors: Akiyama Yo , Iwaki Maiko , Komagamine Yuriko , Minakuchi Shunsuke , Kanazawa Manabu
Published: November 2023

Milling machines have made denture fabrication possible with high accuracy in a short time. However, the relationship between the milling conditions, accuracy, and milling duration has not been clarified. This study aimed to clarify the effects of milling conditions on surface roughness and milling duration. The specimen was designed using a CAD software, and milled using PMMA disks. In milling, the parameters of finishing the specimen surface were adjusted. Three different spindle speeds and four different feed rates were set. Twelve combinations of each parameter were used for milling, and the surface roughness and milling duration were measured. Results showed that the surface roughness significantly increased with the feed rate on the slopes of the specimen. The surface roughness differed with the spindle speed on the left and right slopes. The spindle speed and feed rate did not affect the surface roughness on the flat surface. The milling duration was not affected by spindle speed but decreased as the feed rate increased. In conclusion, by increasing both the spindle speed and feed rate, the milling duration could be shortened while maintaining a constant surface quality. The optimum milling conditions were a spindle speed of 40,000 rpm and feed rate of 3,500 mm/min.
Women of Color in the Health Professions: A Scoping Review of the Literature
Authors: Okoro Olihe , Umaru Omolayo , Ray Meghana
Published: November 2023

Women of color (WoC) in the health professions encounter challenges in advancement to higher positions, disparities in wages, discrimination, lack of expectation to achieve leadership positions, and absence of extensive support networks. Articles in the literature have addressed race and/or gender in the context of professional development. However, applying an intersectionality lens or framework to better understand the contextual issues of professional development for WoC remains to be addressed. Thus, this scoping review aimed to (i) identify health professions literature that addresses disparities affecting WoC, and (ii) describe strategies and approaches to support WoC in the health professions. Methods: Literature searches were conducted in multiple databases. Three independent reviewers reviewed and screened articles for inclusion. Results: 31 articles were included - medicine(17), nursing(1), pharmacy(7), other(4), and multiple health professions(2). Key findings included underrepresentation of women and minority groups, inequities in professional advancement and leadership positions for WoC, and greater dissatisfaction and attrition among minority and women professionals. Conclusion: WoC face unique and distinct challenges and barriers in their professional careers resulting from the intersectionality of not only race and gender, but also lived experiences and opportunities. Strategies to improve diversity and representation should include an intersectionality framework or lens and be critically evaluated.
Relative Comparison of Benefits of Floor-Slab Insulation Methods, Using Polyiso and XPS Materials in South Africa, Subject to the New National Building Energy Efficiency Standards
Authors: Kabundu Emmanuel Kizito , Mbanga Sijekula , Botha Brink , Ayesu-Koranteng Emma
Published: November 2023

This article aims to assess the benefits of floor-slab insulation measures using extruded polystyrene (XPS) and polyisocyanurate (polyiso) insulation materials at various levels of insulation thicknesses for a detached residential building. The EnergyPlus simulation analysis was carried out within the seven energy zones (represented by eight locations) of South Africa in accordance with the South African national code for building energy efficiency (SANS10400-XA). The energy savings and payback periods due to use of the insulation over a lifecycle period of 50 years were assessed. Cape Town (zone 4) behaved differently from other locations and hardly benefitted from the application of floor-slab insulation measures. Generally, polyiso insulation performed better than XPS, for vertical gap insulation. For vertical gap insulation, lower insulation thicknesses required higher insulation depths to maximize energy savings. Similarly, lower insulation thicknesses required higher perimeter insulation widths to maximize energy savings, for the horizontal perimeter insulation method. The locations that benefitted most from vertical gap floor-slab insulation were Pretoria (zone2), Kimberley (zone6), Nelspruit (zone3), Fraserburg (zone7), Welkom (zone1), Mthatha (zone5), Ixopo (zone5H) and Cape Town (zone4) in that order. This order was almost similar with those for the horizontal perimeter floor-slab insulation and horizontal full floor-slab insulation methods.
Optimal Planning of Urban Building-type Integrated Energy Systems Considering Indoor Somatosensory Comfort and PV Consumption
Authors: You Guangzeng , Sun Peng , Lei Yi , Zhang Donghuizhang , Li Haibo
Published: November 2023

Building energy consumption is the main urban energy consumption component, which mainly serves people-centered work and living energy demands. Based on the physical requirements of humans in urban buildings and to determine the comfortable body temperature in each season, this paper establishes a sizing optimization model of building-type integrated energy systems (IES), where the cooling and heating loads required to maintain indoor somatosensory body comfortable temperature are calculated. Depending on the external energy price, internal power balance and other constraints, the model develops an optimal sizing and capacity panning method of energy conversion and storage unit in a building-type IES with PV generation. The operating principle is described as follows: the PV generation is fully consumed, a gas engine satisfies the electric and thermal base load requirements, while the power system and a heat pump supply the remaining loads. The gas price, peak-valley electricity price gap and heat-topower ratio of gas engines are considered as important factors for the overall techno-economic analysis. The developed method is applied to optimize the economic performance of building-type IES and verified by practical examples. The results show that using the complementary characteristics of different energy conversion units is important to the overall IES cost.
Testing and Modeling Performance Growth of PV Water Pumping System Using Multi-Parallel Pumps Switching for An Optimal Hydraulic Power Point Tracking
Authors: Harkani Assia , Fassi H. Fihri , El-Aissaoui Abdellah
Published: November 2023

This research article aims to present implementation and evaluation of the HPPT design based on using multi-parallel pumps switching for yielding performance with reference to potential change of daily irradiance. After that, the curve fitting of the hydraulic performance scenarios is tested to compare the hydraulic energy growth behaviors with reference to exponential and power growth models.
Research on The Application of Mind Mapping in Indonesian-Chinese Character Teaching Review Lesson: A Case Study of The Department of Chinese Language and Culture Universitas Sebelas Maret 心智导图在印尼汉字教学复习课中的应用研究——以 三一一大学中文系为例
Authors: Phanata Stephanie
Published: November 2023

In order to probe the application of mind mapping in the Indonesian Chinese character teaching review lesson, the author attempts to use mind mapping to promote the development of student's writing skills in the Chinese character teaching review lesson. The research object of this article is a junior class student in the Department of Chinese Language and Culture of Universitas Sebelas Maret (first semester, newly exposed to Chinese) 180 mind maps were collected from 90 students and drawn. The analysis results of the observation method, action method, and questionnaire survey method indicate that Chinese character mind mapping is helpful in improving Indonesian students' ability to master Chinese characters and improve their quality and interest in Chinese character learning during the review lesson. When using mind mapping, teachers should try to highlight their strengths and avoid weaknesses. With the popularization of computers and the rapid development of graphic technology, the application of mind maps in Chinese character teaching as a foreign language will gradually be recognized, indicating that the development prospects of mind maps are bright. 

 
FEATURES OF THE DEVELOPMENT OF NATIONAL SELF-CONSCIOUSNESS IN STUDENTS
Authors: Pidbutska Nina , Leonov Roman
Published: November 2023

the article is devoted to the problem of the development of national self-awareness in times of large-scale cultural and historical transformations. The concept of national self-awareness, the idea of it in the works of Western and Ukrainian scientists is studied. The article determined that the main components of national self-awareness are a caring and responsible attitude towards the environment, kindness, sincerity, justice, hard work, patriotism, interest in the history of the native land, interest in the traditions of the people, its culture, self-improvement, love for the native language, mutual assistance. The authors presented a questionnaire aimed at determining the importance of various components of national self-awareness among young people who are getting higher education in different regions of Ukraine. The results of the study are presented, which indicates that in the structure of national self-awareness, young people value the love of their native language, interest in the history of their native land and the traditions of the people, patriotism, justice, mutual assistance, caring and responsible attitude towards the environment. At the same time, they underestimate those components that are related to personal qualities, in particular: self-improvement, hard work, sincerity, kindness.
PSYCHOLOGICAL CORRELATIONS OF RELIGIOUS ACTIVITY OF BELIEVERS
Authors: Kuznetsov Oleksiy , Radko Olga
Published: November 2023

the article is devoted to the study of indicators of religious activity and the use of prayer as coping, existential resources, religious self-regulation, personal virtues. 98 people of different faiths took part in the study. It was found that the higher the manifestation of religious activity as a combination of the ability to religious experiences, actions and a deep inner need to communicate with Theos, the greater the autonomous religious self-regulation and psychological need to use prayer to ensure various coping functions. It is shown that religious activity is positively related to such personal virtues as constancy, integrity, kindness, mercy, humility, prudence and spirituality, however, external religious motivation is related to creativity, love of learning, cheerfulness, love, social intelligence, hope , gratitude and humor, that is, having an adaptive potential for the challenges of the modern life of a believer. In addition, higher indicators of external religiosity predict a higher degree of development of the existential resources of the individual. It was determined that the naturalistic worldview corresponds to a higher degree of development of the moral component of spiritual intelligence, whereas the religious worldview is to a greater extent mutually determined by high indicators of the transcendental component of spiritual intelligence in believers.
ESTIMATION OF EXISTING MODELS OF THE MAXIMUM DURATION OF ACTIVE ENERGY LOSSES IN DISTRIBUTION NETWORKS
Authors: Bodunov Vadim , Gai Oleksandr , Kulko Tetiana , Prystupa Anatoliy
Published: November 2023

Despite the rapid development of electrical networks automation level, and the introduction of Smart Grid intelligent network systems,  there is still a need to use, in addition to instrument accounting, calculation methods, in particular, to estimate the technological losses of electricity. The application of calculation methods in distribution electric networks of medium and low voltage is especially relevant. The main reason is the economic inexpediency of automated measurement of mode parameters at all sections and nodes of distribution networks. At the same time, it is necessary to take into account the impact of daily and seasonal unevenness of load schedules. One of the methods for the approximate calculation of the loading component of technological losses of electricity is the method based on the maximum losses time interval, the analysis of which is considered in this work. It carried out a comparative analysis of existing empirical dependencies for estimating the maximum losses time interval and determined the limits of their use. For each empirical dependence the allowable ranges of such parameters as the normalized value of the duration of use of the maximum load, the factor of the shape of the load schedule and the factor of the maximum were found. Allowable range formation is carried out using characteristic load schedules of transformer substations 110-35/10 kV and 10/0.4 kV, which supply utility and agricultural production and mixed (production and utility) equipment of consumers. It was found that none of the empirical dependences provide acceptable accuracy in estimating the duration of maximum losses for schedules that have significant unevenness, which is typical for seasonal agricultural enterprises, or for sources of non-guaranteed generation. Thus, there is a need for additional research and development of an empirical dependence to estimate the duration of maximum losses for load (generation) schedules with significant unevenness.
INFORMATION AND MEASUREMENT SYSTEM FOR PROBLEMS OF TECHNOLOGICAL CONTROL OF MAYONNAISE
Authors: Hryhorenko Ihor , Momot Maksym , Hryhorenko Svetlana
Published: November 2023

In modern automated production, the main trend in the development of measurements is the transition to machine control and the use of more complex information and measurement systems capable of controlling the technological process. In this connection, the value of the metrological characteristics of each of the measuring channels, which take into account the metrological characteristics of all the blocks included in the measuring channel, increases. The possibility of expanding systems during operation or the possibility of changing their structure depending on production tasks essentially complicates the regulation of requirements for such systems, unlike conventional measuring devices, which are «finished» products, but makes it possible to use key elements of the system to create based on them a new system for solving other problems. This principle is clearly demonstrated in this work. A modern information and measurement system is presented to meet the needs of food industry enterprises specializing in the production of various types of mayonnaise. Mayonnaise is the most common semi-solid seasoning in the world, which can improve the taste of food. The need to develop such a system is related to the fact that there is a need to automate the mayonnaise production process to eliminate the influence of subjective factors on the production process and, in this regard, to improve the quality of products. The fulfillment of this task is achieved by maintaining the parameters of the technological process within the established tolerance limits. Control of the technological process of making mayonnaise and influence on it is possible only thanks to the development of an information and measurement system, which is able to receive information from the object of control thanks to the use of high-precision sensors and influence the technological process through the actions of executive devices. All this makes it possible to avoid an emergency situation and ensure the required quality of products. The structural diagram of the system, the main elements of its elemental base, on the basis of which the electrical schematic diagram of the information and measurement system was developed, are presented. An analysis of errors and uncertainty was carried out, which confirms the high accuracy of the proposed version of the system construction.
PRODUCTION TECHNOLOGY OF RADIO-TRANSPARENT CERAMIC MATERIALS
Authors: Lisachuk Georgе , Kryvobok Ruslan , Voloshchuk Valentyna
Published: November 2023

Ceramic radiotransparent materials are non-metallic materials that ensure the transmission of electromagnetic radiation in the radio frequency range of 105–1012 Hz with minimal dielectric losses in the operating temperature range (tgδ 10-2–10-5, ε < 10) and a low value of the radio wave reflection coefficient (P < 1 %). Ceramic radiotransparent materials are used to create rocket and aircraft fairings that protect antenna systems from external factors. For the synthesis of radiotransparent ceramic materials, it is expedient and promising to use such crystalline phases as celsian (BaAl2Si2O8) and slawsonite (SrAl2Si2O8) due to their low dielectric constant and dielectric loss tangent, as well as rather high thermal stability and melting point compared to other aluminosilicate compounds (mullite, spodumene, cordierite, etc.). The development of technology for obtaining radio-transparent ceramic antenna fairings and elements of protective structures of antenna systems of aviation facilities based on the BaO (SrO) – Al2O3 – SiO2 system is relevant. For the formation of complex profile ceramic radiotransparent materials slurry casting in porous gypsum molds is used. In order to compare the developed ceramic compositions, the physico-mechanical, dielectric and electrodynamic properties were studied under normal conditions and in the millimeter frequency range (26-38 GHz). As a result of the research, the following have been developed: a technology for the production of ceramic radiotransparent materials based on slawsonite by semi-dry pressing method, based on celsian-slawsonite by slip casting method and based on celsian or slawsonite by slip casting method. It has been established that the developed materials meet the technical requirements for radio-transparent ceramic materials and can be used to produce elements of protective structures of antenna equipment, such as nose fairings for aircraft.
MEASUREMENT OF LINEAR VELOCITY USING A MOBILE ROBOTIC PLATFORM WITH COMPUTER VISION
Authors: Vorobiov Bohdan , Senchenko Serhii , Kyrylenko Yaroslav , Likhno Yaroslav , Khan Liu , Kutovyi Yurii
Published: November 2023

This article presents an approach to integrating computer vision algorithms into the control system of traction electric drives in rail transport. It demonstrates the utilization of computer vision algorithms for calculating linear velocity as an alternative to conventional sensors like wheel odometers, GPS, DGPS and inertial sensors, which may prove ineffective on slippery surfaces and at low speeds. As a result, this article focuses on employing linear velocity as feedback within the control system to enhance power efficiency during starting and stopping and to prevent wheel slip. The electric drive control system has been successfully implemented and tested on a robotics platform designed for simulating dynamic behaviors in real rail transports scenarios. The article details the development process of this robotics platform, which is employed to mimic real-world dynamic conditions in rail transport. The proposed control algorithm for speed estimation is assessed using a specially designed test bench, revealing its capability to predict speed with a relatively high degree of accuracy. Additionally, an optical flow algorithm for velocity estimation is introduced and evaluated through a specially designed test rig, indicating a strong correlation between the predicted vehicle speed and the measurements from precision optical encoders. The study also determines the optimal feature window size for real-time optical flow rate estimation. In summary, this approach exhibits significant potential for accurate speed estimation. Ongoing experiments are being conducted under various real-world conditions, with future research aimed at developing a dependable autonomous system for speed measurement. The integration of modern digital computer vision technologies not only enhances the traction characteristics of electric drives but also extends the capabilities of traction electric drives to meet the rigorous demands of industrial equipment.
Анализ динамики эпидемического процесса COVID-19 в мире за неделю с 04.11.2023 г. по 10.11.2023 г.
Authors: Зимирова Анастасия , Поспелов Михаил , Иванова Александра , Карнаухов Игорь , Щербакова Светлана , Кутырев Владимир , Дмитриева Людмила
Published: November 2023

В обзоре представлен анализ эпидемиологической ситуации в странах мира по COVID-19 за неделю с 04.11.2023 г. по 10.11.2023 г.
Academic Spaces and Architectural Composition
Authors: Mariani Leandro , Magalhães Mariani Maria de Fatima , Brazeiro Carlos Thiago
Published: November 2023

This paper sought to develop an architectural proposal for a campus. The analysis of historical aspects of the implementation of higher education in Brazil was essential to understand the notion of campus and the relationship between architectural design and the restructuring of the teaching model in the 1960s The architectural design of the university campus in Brazil is inserted in the context of Modern Architecture and in the principles of the Charter of Athens. The pioneering institutions in this model, UnB and Unicamp, promoted the review of academic programs aligned with the innovation of the physical structure of space to promote university integration. The period from 2000 to 2010 was expressive in the creation of new campuses, many located in the interior cities. In this context, Univasf stands out, whose most recent campus is Salgueiro-PE, with courses in Production and Computer Engineering. Univasf's initiative for Salgueiro contributed to the choice of land for the implementation of the architectural design. The bibliographical research was significant to understand the process of the emergence of the campus in Brazil, to know the history of the constitution of academic spaces and the importance of university architecture. The pioneer institutions in this model, UnB and Unicamp, promoted the review of academic programs aligned with the innovation of the physical structure of the space to promote integration. In view of this, UNIVASF's Salgueiro campus was chosen as a reference for further analysis of the architectural proposal for a campus under development.
RETRACTED: Geometrical Modeling and Experimental Validation of 3D woven Honeycomb Fabric for Lightweight Aircrew Helmet Liner Manufacturing
Authors: Singh Omender , Behera B. K
Published: November 2023

The authors have requested that this preprint be removed from Research Square.
Effect of Relative phase of loose tie rods on nonlinear dynamic behavior of rod-fastening rotor-bearing-seal system
Authors: Wu Xianglin , Jiao Yinghou , Gu Xiaohui
Published: November 2023

The circumferential rod-fastening rotor is composed of multiple disks fastened together by preload provided by tie rods evenly distributed along the circumference of rotor. After the rotor has been running for a period of time, some tie rods will loosen and fail to provide preload due to thermal load, centrifugal load, etc. Which causes the preload that was originally evenly distributed in the circumferential direction to become uneven. Uneven preload introduces anisotropy of contact interface stiffness between rotor disks and generalized bending moments, which have important effects on nonlinear dynamic characteristics of rotor-bearing-seal system. Further, it is common for multiple tie rods to become loose at the same time in practical engineering, the relative position of loose tie rods in the circumferential direction will also have an important impact on rotor dynamics. The relevant research has not been done yet. In this paper, a contact model of the rough machined surface is firstly established by combining the statistical contact theory and fractal contact theory, and then the contact stiffness model between disks is established based on the contact model. Finally, the dynamic model of the circumferential rod-fastening rotor-bearing-seal system is established and solved. The effect of relative phase of loose tie rods on the nonlinear dynamic characteristics of rod-fastening rotor-bearing-sealing system is studied. It can be concluded that relative phase of the loose tie rod has an important influence on the frequency, bifurcation, and periodic motion of the rotor system. At lower speed, the anisotropy of contact stiffness caused by loose rods has little effect on the rotor trajectory, while the generalized bending moment has a greater influence on dynamics of the system. At higher speed, the anisotropy of contact stiffness has a great influence on the axis rail of the rod-fastening rotor.
The Experience and Influence of Youth in China in Coping with Stressful Life Events during the Post–COVID-19 Pandemic Era: A Qualitative Study
Authors: Guo Yannan , Xu Ziruo , Ding Hexiao , Wang Cailing , Peng Xinran , An Yuping , Wang Jing , Hu Wangjing , Li Sicheng , Hui Zhengyang , Xia Wei
Published: November 2023

Background:
The COVID-19 pandemic has had a profound effect on the mental well-being of individuals, particularly among the youth. The experience of stressful life events has been linked to increased poor mental health. While the immediate effects have been documented, there is evidence to suggest that the pandemic’s impact on mental health could persist in the long run. Additionally, the pandemic has influenced coping strategies and forms of social support.
Methods:
A phenomenological descriptive study was conducted to elucidate the changes in strategies adopted by youth to cope with stressful life events during the COVID-19 era. Thirty-three Chinese youths aged 15 to 24 years who have experienced regular COVID-19 pandemic prevention and control were invited to complete a semi-structured interview. Colaizzi’s method was used to analyze the data. Triangulation was adopted to ensure the validity.
Results:
Four key themes were generated, including (1) negative changes in mental health, (2) positive changes in mental health, (3) changes in the adoption of coping strategies, and (4) the utilization of internet-based coping strategies.
Conclusions:
The results could guide the development of interventions to help the youth cope with stressful life events and further promote mental health among this population.
Trial registration:
This study has prospectively been registered on the Chinese Clinical Trial Registry (ID: ChiCTR2200060894) on 14/06/2022.
WITHDRAWN: Molecular and cytogenetic analyses in Geranium macrorrhizum L. wild Italian plants
Authors: Cardinali Irene , Ceccarelli Marilena
Published: November 2023

Geranium macrorrhizum L. is a herbaceous species native to southern Europe, and introduced in central Europe and North America. It is widely distributed also in Italy, up to Campania region as the southern limit. In this study, molecular and cytogenetic analyses were carried out on 22 wild plants, collected in central and southern Italy, compared to five cultivated plants, with the main purpose to identify those living near the Marmore waterfalls in central Italy, recently described as the new species G. lucarinii. Four barcoding markers (rbcL, matK, trnH-psbA intergenic spacer, and internal transcribed spacer region, ITS) were sequenced and their variability among the plants was evaluated. Chromosome numbers were determined and 45S rDNA was physically mapped by fluorescence in situ hybridization (FISH) in both wild and cultivated plants. Moreover, genomic affinity between wild and cultivated plants was evaluated by genomic in situ hybridization (GISH). Our results confirmed that all the plants, including Marmore population, belong to G. macrorrhizum. Barcoding analyses showed a close similarity among the wild plants, as well as a differentiation, although not significant, between the wild plants on one hand and the cultivated plants on the other. Integrated studies focusing on morphological, genetic and ecological characterization of a larger number of wild populations will allow for knowing the extent of the variability within the species.
Ameliorative Effects of Alchornea cordifolia Extract on Bisphenol A-Induced Obesity in Wistar rats
Authors: Agboola Abdulhakeem Rotimi , Itam Ako Hogan , Ekeleme Chinedum Martins , Agwupuye Eyuwa Ignatius , Ahmed Zuwairatu Oyiza , Igiakong Godswill Peter , Agbor Gideon Bassey , Abubakar Asmau Niwoye , Adamu Zainab , David-Oku Esien
Published: November 2023

Background
Bisphenol A (BPA) is a chemical found in plastic bottles and has been linked to obesity and its associated health problems. Due to the cost and possible side effects that are associated with the orthodox medications employed for weight management, there is a shift in attention to local medicinal plants as they are readily available and are believed to be free from negative side effects. One plant that has found application for weight loss amongst the local population in Nigeria is Alchornea cordifolia which commonly grows in Africa and has been confirmed to possess numerous medicinal properties which include; anti-inflammatory, anti-diarrheal, hepaprotective, antiviral, and anti-diabetic effects.
Objective:
To investigate the effects of Alchornea cordifolia ethanol extract (ACEA) against the harmful impacts caused by BPA-induced obesity in Wistar rats.
Methods
ACEA was prepared and tested on BPA-induced Wistar rats. Thirty (30) young male Wistar rats were divided into five groups with six rats per group where Group 1 (Normal control) received commercial feed and water only, Group 2 (BPA) received commercial feed and 50 mg/kg of BPA, Group 3 (BPA + Orlistat (30 mg/kg), Group 4 (BPA + A.cordifolia (500 mg/kg)) ethanol extract of A.cordifolia, Group 5 (BPA + A.cordifolia(1000 mg/kg) ethanol extract of A.cordifolia. The parameters studied after obesity was induced and after treatments are; Anthropometric parameters; body weight, waist circumference, lees index and biochemical and kidney function parameters; fasting blood glucose, serum glucose, total protein, relative weight of the kidneys, serum levels of urea, creatinine, uric acid, concentrations of sodium, chloride, and potassium, serum levels of total cholesterol (TC), triacylglycerides (TAG), high-density lipoprotein cholesterol (HDL-c) lipase, low-density lipoprotein cholesterol (LDL-c) and HMG-CoA reductase activity.
Results
Results showed that Bisphenol-A caused obesity and related complications after 4 weeks of administration as evidenced by the elevation of the anthropometric, biochemical and kidney function parameters. However, treatment with low (500 mg/kg) and high dose (1000 mg/kg) of A.cordifolia reduced the elevated levels of the anthropometric, biochemical and kidney function parameters in the Wistar rats.
Conclusion
The results obtained from this study demonstrates the potential of ACEA in the management of obesity and its related complications
Molecular evaluation of SARS-CoV-2 in post-vaccinated patients of Malakand division Khyber Pakhtunkhwa
Authors: abbas waseem , Amir Syed , Rafiullah
Published: November 2023

Coronavirus disease (COVID-19) is one of the epidemic diseases caused by the SARS-CoV-2 virus. The priority of the health community is the development of various reliable vaccinations to combat the COVID-19 pandemic. Some vaccines have been developed to combat the Covid-19 pandemic and humans have been allowed to use. However, vaccinated people have had frequent infections in many areas. The purpose of this study is to find out the efficacy of the SARS-CoV-2 vaccine in Malakand Division. A total of 500 samples were collected from infected subjects through nasopharyngeal swabs. The samples were then categorized based on vaccination type and efficacy. The RNA was extracted and subjected to RT-PCR for detection SARS-CoV-2. Out of 500 vaccinated individuals, 173 were positive. The rate of SARS-CoV-2 recurrent infections was high among all subjects. The most effective vaccines were Pfizer BioNTech with an efficiency 85%. The remaining vaccines such as Moderna showed an efficiency of 75%, Sputnik-V vaccine (73%), AstraZeneca (72%), CoronaVac-SinoVac (60%), Sinopharm BBIBP (55%) and Cansino Vaccine (50%). The study concludes that Pfizer BioNTech is the most effective vaccine among all the tested vaccines and can be recommended to minimize the risk of recurrent infection.
Metabolic Engineering of Escherichia coli for the Production of 5-Aminolevulinic Acid Based on Combined Metabolic Pathway Modification and Reporter-Guided Mutant Selection (RGMS)
Authors: Yang Yuting , Zou Yuhong , Chen Xi , Sun Haidong , Hua Xia , Johnston Lee , Zeng Xiangfang , Qiao Shiyan , Ye Changchuan
Published: November 2023

Background
5-Aminolevulinic acid (ALA) recently received much attention due to its potential application in many fields such as medicine, nutrition and agriculture. Metabolic engineering is an efficient strategy to improve microbial production of 5-ALA.
Results
In this study, an ALA production strain of Escherichia coli was constructed by rational metabolic engineering and stepwise improvement. A metabolic strategy to produce ALA directly from glucose in this recombinant E. coli via both C4 and C5 pathways was applied herein. The expression of a modified hemARS gene and rational metabolic engineering by gene knockouts significantly improved ALA production from 765.9 to 2056.1 mg/L. Next, we tried to improve ALA production by RGMS-directed evolution of eamA gene. After RGMS, the ALA yield of strain A2-ASK reached 2,471.3 mg/L in flask. Then we aimed to improve the oxidation resistance of cells by overexpressing sodB and katE genes and ALA yield reached 2703.8 mg/L. A final attempt is to replace the promoter of hemB gene in genome to inhibit the hemB gene. After 24 h cultivation, a high ALA yield of 19.02 g/L was achieved by 108-ASK in a 5 L fermenter.
Conclusions
These results suggested that an industrially competitive strain can be efficiently developed by metabolic engineering based on combined rational modification and optimization of gene expression.
Protein and transcript expression levels of TRIP13 signify worse prognosis in endometrioid carcinoma
Authors: Wu Quan , Wang Zitong , He Cai , Guo Jingwei , Xu Chengcheng , Gao Yehan , Zhang Yichen , Ma Jiajie , Wang Zhe
Published: November 2023

This study investigated the genes implicated in endometrioid adenocarcinoma development to provide insights into the molecular diagnosis, targeted therapy, and prognostic prediction of the disease. Two mRNA microarray datasets were obtained from the Gene Expression Omnibus. Differentially expressed genes were identified, and a protein–protein interaction network was constructed. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were performed on the genes within the network modules. Prognostic significance was determined through a survival analysis to identify the key genes. The UALCAN website was used to validate TRIP13 mRNA expression, and immunohistochemical staining was performed to evaluate TRIP13 protein expression in patient samples. Sixteen genes were significantly associated with patient prognosis. The results revealed significantly elevated TRIP13 transcription and protein expression levels in endometrial cancer tissues compared to those in normal tissues. High TRIP13 expression was significantly correlated with shorter survival and considered an independent risk factor for endometrioid adenocarcinoma. Further, a negative correlation between TRIP13 expression and infiltrating CD8 + T cell levels in uterine corpus endometrial carcinoma was observed. This study validated the correlation between TRIP13 expression and poor patient prognosis, suggesting that TRIP13 may be a biomarker for endometrioid adenocarcinoma prognosis predictions.
Properties of layer V pyramidal neurons in the primary motor cortex representing acquired motor skills
Authors: Kida Hiroyuki , Sakimoto Yuya , Mitsushima Dai
Published: November 2023

Layer V neurons in primary motor cortex (M1) are required for motor skill learning. We analyzed training-induced plasticity using a whole-cell slice patch-clamp technique with a rotor rod task, and found that training induces diverse changes in intrinsic properties and synaptic plasticity in M1 layer V neurons. Although the causal relationship between specific cellular changes and motor performance is unclear, by linking individual motor performance to cellular/synaptic functions, we identified several cellular and synaptic parameters that represent acquired motor skills. With respect to cellular properties, motor performance was positively correlated with resting membrane potential and fast afterhyperpolarization, but not with the membrane resistance, capacitance, or threshold. With respect to synaptic function, the performance was positively correlated with AMPA receptor-mediated postsynaptic currents, but not with GABAA receptor-mediated postsynaptic currents. With respect to live imaging analysis in Thy1-YFP mice, we further demonstrated a cross-correlation between motor performance, spine head volume, and self-entropy per spine. In the present study, among the diverse changes that occur in M1 layer V pyramidal neurons after motor training, we identified several changes that represent acquired motor skills. These results suggest that systematic control of specific intracellular parameters and enhancement of synaptic plasticity in M1 layer V neurons may be useful for improving motor skills.
The Cycles of Decrees: Evidence From the Italian Parliament 1
Authors: Lagona Francesco , Mingione Marco , Padovano Fabio
Published: November 2023

This research provides an empirical test of the predictions of the Political Legislation Cycle theory about decrees using disaggregated data made recently available by official databanks of the Italian Republic. The analysis focuses on the five different types of decrees for which long enough data series are available: law-decrees (decreti legge), legislative decrees (decreti legislativi), DPR (decrees of the President of the Republic), implementing decrees (decreti attuativi) and independent decrees (decreti indipendenti). Multiple sources of latent heterogeneity affect the production of decrees due to multilevel factors that operate jointly with observed covariates at all levels of the hierarchy of the data. We account for these factors by estimating a multilevel negative binomial regression model with random effects on the mean for repeated measurements of disaggregated counts of decrees, implemented under multiple Italian governments, nested within the first 17 legislatures of the Italian Republic. The estimates of the model broadly confirm the theory’s prediction that decrees tend to be approved in the earlier stages of the legislature; this prediction receives stronger support the more the institutional characteristics of each type of decree resemble those of the theoretical variable. Finally, the analysis confirms the prediction of the PLC theory about the legislators’ choice of the legislative instruments through which they satisfy the conflicting interests of special interest groups and voters, shedding light on the timing of the activities of lobbies.
JEL classification codes: D72, C49, H61, H62
Unlocking Corrosion Secrets: A Comprehensive Analysis of Acoustic Emission Data Using Continuous Wavelet Transform and Deep Learning for Steel Pipeline Monitoring
Authors: Hassan Farrukh , Rahim Lukman AB , Khan Muhammad Irfan , Adnan Muhamed Hariz Mohamed , Ali Shahid , Qayyum Faiza
Published: November 2023

The analysis of acoustic emission data in the time and frequency domains can provide useful insights about the state of steel pipelines, although research in this field is limited. The research shortage has been triggered due to specific problems provided by elements such as irregular structure geometries, material dependencies, and insufficient training data. To address the lack of training data, we created a new dataset of scalogram images for deep learning-based classification approaches. Monitoring a 500-meter-long steel oil and gas pipeline provided experimental data. The acoustic emission waveforms were preprocessed, tagged, and classified based on three critical characteristics: AE-mean, kurtosis, and amplitude. The continuous wavelet transform was used to translate these waveform instances into the time-frequency domain. To. The abstract should be an objective representation of the article and it must not contain results that are not presented and substantiated in the main text and should not exaggerate the main conclusions. State-of-the-art deep convolutional neural networks were used as benchmarks to assess the effectiveness of the proposed dataset. Surprisingly, the unique dataset achieved a classification accuracy of 91.0%. Furthermore, the impact of initial learning rate and L2 regularization hyperparameters were evaluated for EfficientNet-b0. The availability of this dataset opens the door to a plethora of corrosion detection applications, providing substantial prospects in this field.
Black holes regulate cold gas accretion in massive galaxies
Authors: Wang Tao , Xu Ke , Wu Yuxuan , Shi Yong , Elbaz David , Ho Luis , Zhang Zhi-Yu , Gu Qiusheng , Wang Yijun , Shu Chenggang , Yuan Feng , Xia Xiaoyang , Wang Kai
Published: November 2023

Nearly every massive galaxy contains a supermassive black hole (BH) at its center. For decades, both theory and numerical simulations have indicated that BHs play a central role in regulating the growth and quenching of galaxies. Specifically, BH feedback by heating or blowing out the interstellar medium (ISM) serves as the groundwork for current models of massive galaxy formation. However, direct evidence for such an impact on the galaxy-wide ISM from BHs has only been found in some extreme objects. For general galaxy populations, it remains unclear whether and how BHs impact the ISM. Here based on a large sample of nearby galaxies with measurements of masses of both black holes and atomic hydrogen, the major component of cold ISM, we reveal that the atomic hydrogen content ( fHI = MHI/M*) is tightly and anti-correlated with black hole mass (M_BH) with f_HI ~M_BH^(-α) (α ∼ 0.5 − 0.6). This correlation is valid across five orders of magnitude in M_BH. Once this correlation is taken into account, fHI loses dependence on other galactic parameters, demonstrating that M_BH serves as the primary driver of fHI. These findings provide critical evidence for how the accumulated energy from BH accretion impacts galaxy-wide ISM, representing a crucial step forward in our understanding on the role of BHs in regulating the growth and quenching of massive galaxies.
Design, Formulation, Evaluation and Statistical Optimization of Coated Floating Pulsatile Tablets for Modified Chronopharmacotherapy of Rheumatoid Arthritis
Authors: jyothirmayi pasam
Published: November 2023

Objective
The main aim of designing Coated Floating Pulsatile Tablets (CFPT) of Tramadol hcl for statistical optimization and to perform in vitro and in vivo buoyancy evaluation for modified chronopharmacotherapy of rheumatoid arthritis.
Methods
The formulation was designed with the immediate core covered with a compression coat followed by the upper buoyant layer. Best formulations of Immediate burst release core tablets were compression coated with polymer HPMC K15M, Ispaghula gum (IG), and Tamarindus gum (TG) to assign suitable lag time to formulation. HPMC K100M, Ispaghula gum, and their combination were compressed as the buoyant layers. Parameters such as BLT, TFT, %SI,% CDR were Statistical optimized by surface and contour plots AND invivo buoyancy was also done.
Results
Immediate release core tablets were optimized with formulation IF2 which contains sodium starch Glycolate 8% as immediate release agent, and then in compression coated buoyant formulation CFPT was optimized by DoE optimization showing BF4 and BF8 exhibiting good floating behavior and lag time, drug release for a period of 11 hrs. Abdominal X-ray imaging of rabbits after oral administration of the tablets, confirmed the floating behavior and lag time.
Conclusion
As the formulation showed delay in drug release both in in vitro and showed in vivo buoyancy, hence nighttime administration could be beneficial to reduce the rheumatoid arthritis complications in the early morning.
Relevance of pathognomonic changes in multiple sclerosis patients in remission for oral and maxillofacial surgery– a pilot study of case series
Authors: Fehlhofer Jakob , Ries Jutta , Nickel Florian Tobias , Rothhammer Veit , Schwab Stefan , Kesting Marco , Buchbender Mayte
Published: November 2023

Objectives
Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of unknown etiology that affects the central nervous system and can lead to neurological impairment. Our aim was to determine whether MS patients also show inflammatory changes in the oral cavity more frequently than healthy individuals.
Material and Methods
We examined plaque samples for various mediators and their correlation with clinical findings. A study group (MS) and a control group were examined and compared. The plaque samples were analyzed for the expression of interleukins (IL-2, -6, -10), matrix metalloproteinases (MMP-7, MMP-9) and a surface antigen CD90 by quantitative real-time PCR. Clinical parameters examined were the Mombelli plaque index (MPI), bleeding on probing (BOP) index, gingival pocket depth (PD) and Decayed, missing and filled tooth (DMFT) index.
Results
The expression of MMP9 was significantly (p = 0.035) higher in the control group. The expression of IL-2 was increased 4-fold in the MS group, but this difference was not statistically significant. The mean PD (p < 0.001) and BOP index (p = 0.029) were increased in the study group.
Conclusion
The clinical parameters of the BOP index and PD were significantly amplified in the MS patients. However, no causal relationship could be established in this case series, thus for the oral and maxillofacial surgical treatment no evidence for restrictions could be derived.
Clinical Relevance
With the worldwide increasing incidence of MS, it’s important to obtain insights into the effects of the disease on the oral cavity. The study was registered in the German clinical trial registry (DRKS00022956, registered 28/08/2020).