bluuebunny/crossref_metadata_2025 huggingface dataset:
Occurrence of Amblyomma rotundatum Koch, 1844 on Epicrates assisi Machado, 1945 in João Pessoa, Paraíba, Brazil
Authors: Batista Aksa Ingrid Vieira , Lucena Gabriel Vinicius Carvalho de , Oliveira Filho Kleber Silva de , Nery Thiago Ferreira Lopes , Martins Thiago Fernandes , Pereira Josivania Soares
Published: October 2021

The Caatinga rainbow boa (Epicrates assisi Machado, 1945) is a snake belonging to the order Squamata, family Boidae, and subfamily Boinae. It has a wide distribution in Brazil and can be found in the Caatinga biome. The present study aims to report the first occurrence of Amblyomma rotundatum on E. assisi in the municipality of João Pessoa, Paraíba State (PB). On March 3, 2020, a tick collection was performed on the dorsal region of the head of an E. assisi, which was captive at the Arruda Câmara Zoobotanical Park, João Pessoa-PB. After collecting the tick, it was transferred to a flask containing 70º alcohol and sent to the Laboratory of Animal Parasitology of the Federal Rural University of the Semi-Arid (UFERSA) for analysis. Identification was done with the aid of a stereomicroscope using a taxonomic key. The result identified this specimen as a nymph of A. rotundatum. The occurrence of this tick species on E. assisi is reported for the first time and constitutes new data applicable to the ectoparasites that occur in this host species in Brazil.
Hematological and histopathological changes in medular aplasia resulting from Ehrlichia canis infection in a Border collie dog
Authors: Neves Carolina Araújo , Moraes Reiner Silveira de , Ogliari Kaline , Severino Neto Antônio Carlos , Ramos Dirceu Guilherme de Souza , Saturnino Klaus Casaro
Published: October 2021

The Canine Monocytic Ehrlichiosis (CME) is an infectious disease that commonly affects dogs of all breeds and ages. It is caused by the bacterium Ehrlichia canis and is transmitted by the tick Rhipicephalus sanguineus. The disease may pre-sent itself in the acute, subclinical, and chronic forms. The present study reports the case of a 2-year-old male Border Collie with advanced stage CME, attended at the Pet Clinic of the Veterinary Hospital of the University Federal de Jataí, which resul-ted in medullary aplasia. The diagnosis of marrow aplasia was based on the necroscopic and histopathological examinations. At necropsy, the diaphyses of the long bones were filled with diffuse, strongly whitish and pasty tissue, typical of the adipose tissue, also found in the femoral epiphyses. The histopathology showed unilocular adipose tissue as the major constituent of the bone marrow and rare islands of marrow cells. These findings were compatible with severe hypoplasia of the red bone mar-row and hyperplasia of the white bone marrow, affecting hematopoiesis, resulting in the laboratory alterations observed in the hematocrit, WBC, and plateletogram.
Clinical, surgical, and radiographic aspects in a white‑eared opossum (Didelphis albiventris) with traumatic diaphragmatic hernia
Authors: Souza Carolina Fucks de , Piccoli Ronaldo José , Quintana Paula Eduarda , Thomas Lettycia Demczuk , Cunha Olicies da , Jojima Flávio Shigueru
Published: October 2021

This is the case of a specimen of Didelphis albiventris with signs of respiratory difficulty after a dog attack. Thoracic radiographic examination revealed pneumothorax, pulmonary contusion, and rib fracture, but no alteration compatible with diaphragmatic hernia was observed. Pneumothorax was reduced and the other alterations were treated. However, clinical manifestations persisted, and thus a contrast-gastrointestinal radiographic study was performed, showing abdominal organs in the thoracic cavity and loss of diaphragmatic line. The surgical approach was instituted, with access to the diaphragm through median laparotomy. Through the diaphragmatic rupture, present in the left antimere, there were herniated liver and gastric portions, intestinal segments, and omentum. After inspection and repositioning of the abdominal organs, the diaphragm raffia was performed with single sutures interrupted with 3-0 Nylon thread. The patient’s complete recovery occurred 14 days after the surgical procedure, with remission of clinical manifestations and normality of thoracic images in radiographic studies.
Uni-Variate and Multi-Variate Short-Term Household Electricity
Consumption Prediction Using Machine Learning Technique
Authors: Tyagi Sakshi , Singh Pratima
Published: October 2021

Background:

Electricity consumption prediction plays an important role in
conservation, development, and future planning. Accurate prediction model has various field
applications in real-life scenarios, future electricity demand estimation, performance evaluation of
current time, fault detection, efficient energy production, resource-saving, and many more. In this
paper, a CNN based short term building electricity consumption prediction model is developed and
tested for two different types of datasets that can perform weekly prediction. Two different
datasets are used to check how the algorithm behaves on different datasets i.e., what are the
impacts dataset has on prediction accuracy. Errors were calculated using MAE and RMSE.

Objective:

The objective of the study is to develop an electricity consumption prediction (ECP)
model for a univariate and multivariate dataset using CNN and LSTM network and to find that
how the correlation and independency of features affect the electricity prediction task.

Methods:

The proposed electricity consumption model is built using the deep CNN andLSTM
network and is trained and tested using the univariate and multivariate time series dataset thus the
two experiments have been performed and are named as U-ECPCL (Univariate- Electricity
Consumption Prediction using CNN and LSTM) and M-ECPCL (Multivariate- Electricity
Consumption Prediction using CNN and LSTM) respectively.

Results:

The model predicts accurately with few errors with MAE of 0.251 and RMSE of 0.66 for
univariate dataset and MAE of 4.36 and RMSE of 11.53 for a multivariate dataset.

Conclusion:

The model predicts accurately with few errors and if the prediction error of univariate
and multivariate are compared then it is concluded that the univariate model outperforms the
multivariate model.
Polymeric Reverse Osmosis and Forward Osmosis Membranes for Water Desalination
Authors: Ang W.L.
Published: October 2021

Polymeric reverse osmosis (RO) and forward osmosis (FO) membranes have been predominantly used in membrane applications for water desalination. The membrane science has advanced in the past decades and various efforts have been employed to improve the membrane characteristics for enhanced water flux and impurities rejection capability. In this chapter, the progress of RO and FO membranes has been discussed in three sections: synthesis methods of RO and FO membranes, modification works done on the membranes and the formulation used for the synthesis of RO and FO membranes, with particular interest given to the incorporation of nanoparticles in the synthesis of thin film composite membrane.
Polymeric Membranes for H2 and N2 Separation
Authors: Wu J.
Published: October 2021

H2 and N2 separations are of paramount importance to the global development of clean energy and environment. While the traditional thermal-driven processes are often deemed overly energy-intensive, the polymeric membrane technology presents an energy-efficient and potentially cost-effective alternative that comes with many operational and environmental advantages to offer. However, a variety of key challenges revolving around the membrane performance and stability issues require new material innovations in order to be eventually overcome. This chapter provides the background for polymeric gas separation membranes and also a detailed evaluation on state-of-the-art polymeric membrane materials for H2 and N2 separations. Performance enhancement strategies will also be discussed in the later parts.
HIGH ALTITUDE PULMONARY EDEMA (HAPE)
Authors: Khiptiyah Mariyatul , Sartono Teguh Rahayu , Normahayu Indrastuti , Jaya Wiwi
Published: October 2021

Â Introduction:Â High altitudeÂ pulmonary edema (HAPE) is one of the acute, severe, non-cardiogenic disease that could be life threatening,Â occurs upon either the first or subsequent exposure to high altitude. It is triggered by a shortage of oxygen after ascending high altitude. The most effective therapeutic approach for HAPE is to immediately descend from high altitude and to give oxygenation, maintaining arterial saturation over 90%, as well as letting the patient rest from strenuous physical activity. The use ofÂ portable hyperbaric chamberÂ is also deemed effective in certain circumstance, and nifedipine can also be used to treat HAPE, even as additional treatment in condition that the patients had yet to descend and oxygenation is still not administrable.Â Case Report: We reported a case at Rs. Dr. Saiful Anwar, a 23-year old male with High Altitude Pulmonary Edema (HAPE). Diagnosis established from anamnesis, physical examination, and laboratory tests. Patient complained shortness of breath when climbing Mt. Semeru, in which the patient reached an altitude of 2700 mdpl in 2 days. Physical examination showed oxygen saturation 46-49% with NRBM 10 lpm, and rhonchi breath sound in all lung areas. Laboratory examination showed leukocytosis, blood gas analysis showed hypocarbia,Â severe hipoxemia,Â metabolic acidosis, and type I respiratory failure. Ches XRay showed wide, irregular infiltrate in both lungs. Based on those, the patient was diagnosed with HAPE. In this case, the patient was given oxygenation.Conclussion: In this case, the patient was diagnosed with HAPE based on anamnesis, physical examination, and laboratory tests. Oxygenation given to the patient improved his condition.Key words: High altitude disease, Acclimatization, Pathophysiology, Management and treatment
RISK FACTORS FOR THE OCCURRENCE OF PRIMARY OPEN-ANGLE GLAUCOMA IN PATIENTS WITH DIABETIC RETINOPATHY AND TYPE 2 DIABETES
Authors: Gudzenko K. A. , Mogilevskyy S. Yu. , Kyryliuk М. L. , Ziablitsev D. S.
Published: October 2021

The aim of this work was to identify risk factors for the occurrence of primary open-angle glaucoma in patients with diabetic retinopathy and type 2 diabetes mellitus by conducting a regression analysis of the mutual influence of these diseases. We examined 649 patients (649 eyes), among whom 301 patients (301 eyes) had diabetic retinopathy and glaucoma; 164 patients (164 eyes) had diabetic retinopathy only; 81 patients (81 eyes) had only glaucoma and 103 patients (103 eyes) did not have these diseases (control). The construction of logistic regression models was carried out in the GLZ module of the Statistica 10 software (StatSoft, Inc. USA). It was found that the development of primary open-angle glaucoma directly depended on the duration of diabetes and the intraocular pressure level, and vice versa — on visual acuity (p < 0.001). The development of diabetic retinopathy did not depend on the presence of glaucoma, but it was directly dependent on the blood content of glucose and glycated hemoglobin. Men had a lower risk of developing diabetic retinopathy than women(OR = 0.800; 95% CI 0.76-0.84). Also, men had a lower risk of glaucoma (OR = 0.95; 95% CI 0.94–0.96). Stratification by stages of diabetic retinopathy showed the effect of intraocular pressure, decreased visual acuity and glaucoma stages on the development of proliferative diabetic retinopathy (p < 0.001). Increased intraocular pressure was an independent factor in the development of retinopathy. The development of glaucoma of the initial stage was directly influenced by an increase of blood glycated hemoglobin and by the stage of diabetic retinopathy. The occurrence of stage 2 glaucoma was influenced by the duration of diabetes and visual acuity, stage 3 glaucoma — by visual acuity, and stage 4 glaucoma – by the age and duration of diabetes. Independent risk factors for glaucoma were duration of diabetes, increased intraocular pressure, and low visual acuity. When stratified by stage, there was no evidence of a reduction in the risk of developing diabetic retinopathy and glaucoma in men. Thus, the features of the mutual influence of the development of diabetic retinopathy and primary open-angle glaucoma in type 2 diabetes mellitus have been established.
PERSONALIZED THYROID HYPOFUNCTION THERAPY STRATEGY
Authors: Kravchun Nonna , Dunaieva Inna , Kozakov Olexander
Published: October 2021

In the current conditions, coronavirus infection is often the cause of the development of inflammatory and autoimmune diseases of the thyroid gland. One of these diseases can be subclinical hypothyroidism — the initial stage of development of manifest hypothyroidism. Signs of hypothyroidism include weight gain, edema, decreased mental activity, increased drowsiness, dry skin, bradycardia, cardiomyopathy, constipation, muscle cramps, and paraesthesia. Because SG is asymptomatic by definition, 25–50% of patients have slow but characteristic signs of hypothyroidism, manifested by disorders of many organs and systems. Unfortunately, in most cases, such clinical manifestations are assessed retrospectively after the detection of characteristic hormonal changes. The expediency of treating both subclinical hypothyroidism and manifest hypothyroidism is evaluated individually, especially for the elderly, depending on the level of Thyroid-Stimulating Hormone and the presence of comorbid pathology. Synthetic levothyroxine remains the drug of choice for all forms of hypothyroidism. The generally accepted starting dose of levothyroxine for adult 13 patients, according to the recommendations of ATA, is considered a dose of 1.6–1.8 mcg/kg of body weight. Eutirox is a drug that has a unique line of 6 dosages in increments of 25 mcg of Levothyroxine and now the drug has an updated composition that fully ensures the balanced functioning of the thyroid gland. The updated composition is completely bioequivalent to the previous composition with similar tolerability. The increased requirements for the composition of the active substance, which was achieved in the updated composition of Eutirox, has advantages for patients, since hormone fluctuations will be minimized and this will help to avoid the development of adverse clinical consequences.
Snodgrass procedure for distal penile and mid-shaft hypospadias repair in children
Authors: Zadykyan S. S. , Zadykyan R. S. , Sizonov V. V. , Kagantsov I. M.
Published: October 2021

Introduction. Hypospadias is one of the most frequent penile malformations in newborn boys. Warren Snodgrass developed the «tubularized incised plate» (TIP) urethroplasty that is the most often procedure used in the surgical treatment of distal hypospadias for the last 20 years. Despite the great popularity of the technique, its no less famous Grafted TIP (GTIP) modification appeared. The technique is aimed at filling the defect in the urethral site with a foreskin free flap followed by tubularized urethroplasty.

Purpose of the study. To compare the outcomes of TIP and GTIP procedures in our clinic which have been performed in the last 10 years.

Materials and methods. One hundred-fourteen boys with hypospadias (aged 6 mo – 15 years) were operated on using the TIP technique and its modification GTIP during 2010 – 2020 (Sochi Center of Motherhood and Childhood Protection). The patients were: boys up to 1 year – 27 (23.7%), from 1 to 3 years – 57 (50%), 4 – 7 years – 19 (16.7%), from 8 to 14 years – 14 (12.3%). Primary repair was done in 112 cases (98.2%), the second procedure was done in 2 (1.8%) cases. There were 94 (82.5%) boys with distal hypospadias and 20 (17.5%) children with mid-shaft hypospadias. All patients were examined 3 and 12 months after surgery. We assessed the degree of skin scar process on the penile shaft, the location of the meatus and the quality of urination during the examination.

Results. We observed 27 (23.7%) complications after urethroplasty out of 114 treated boys. There were 13 (11.4%) cases of urethral fistula, which were secondary repaired 6 months later. Meatal stenosis was observed in 2 (1.8%) cases, which required secondary meatoplasty. Repeat urethroplasty was done in 10 (8.7%) cases due to neourethral suture failure. There were also 2 (1.8%) cases of secondary penile curvature that required repeat surgery. The good cosmetical and functional results were achieved finally in all children.

Conclusion. The analysis of our ten-year experience of using TIP-urethroplasty and its GTIP modification did not reveal significant differences in the overall incidence of postoperative complications. Yet, using the TIP procedure is associated with more fistulas. There were more cases of urethral suture failure in children whom the GTIP technique was performed. Our data suggest the need for a selective approach in the formation of indications for using TIP and GTIP procedures, along with research aimed at finding criteria for patient selection.
A Tool to Assess the Trustworthiness of Evidence-Based Point-of-Care Information for Health Care Professionals (CAPOCI): Design and Validation Study (Preprint)
Authors: Lenaerts Gerlinde , Bekkering Geertruida E , Goossens Martine , De Coninck Leen , Delvaux Nicolas , Cordyn Sam , Adriaenssens Jef , Aertgeerts Bert , Vankrunkelsven Patrik
Published: October 2021

BACKGROUND

User-friendly information at the point of care for health care professionals should be well structured, rapidly accessible, comprehensive, and trustworthy. The reliability of information and the associated methodological process must be clear. There is no standard tool to evaluate the trustworthiness of such point-of-care (POC) information.

OBJECTIVE

We aim to develop and validate a new tool for assessment of trustworthiness of evidence-based POC resources to enhance the quality of POC resources and facilitate evidence-based practice.

METHODS

We designed the Critical Appraisal of Point-of-Care Information (CAPOCI) tool based on the criteria important for assessment of trustworthiness of POC information, reported in a previously published review. A group of health care professionals and methodologists (the authors of this paper) defined criteria for the CAPOCI tool in an iterative process of discussion and pilot testing until consensus was reached. In the next step, all criteria were subject to content validation with a Delphi study. We invited an international panel of 10 experts to rate their agreement with the relevance and wording of the criteria and to give feedback. Consensus was reached when 70% of the experts agreed. When no consensus was reached, we reformulated the criteria based on the experts’ comments for a next round of the Delphi study. This process was repeated until consensus was reached for each criterion. In a last step, the interrater reliability of the CAPOCI tool was calculated with a 2-tailed Kendall tau correlation coefficient to quantify the agreement between 2 users who piloted the CAPOCI tool on 5 POC resources. Two scoring systems were tested: a 3-point ordinal scale and a 7-point Likert scale.

RESULTS

After validation, the CAPOCI tool was designed with 11 criteria that focused on methodological quality and author-related information. The criteria assess authorship, literature search, use of preappraised evidence, critical appraisal of evidence, expert opinions, peer review, timeliness and updating, conflict of interest, and commercial support. Interrater agreement showed substantial agreement between 2 users for scoring with the 3-point ordinal scale (τ=.621, P<.01) and scoring with the 7-point Likert scale (τ=.677, P<.01).

CONCLUSIONS

The CAPOCI tool may support validation teams in the assessment of trustworthiness of POC resources. It may also provide guidance for producers of POC resources.
A Serious Game for Young People With First Episode Psychosis (OnTrack>The Game): Qualitative Findings of a Randomized Controlled Trial (Preprint)
Authors: Jankowski Samantha , Ferreira Kathleen , Mascayano Franco , Donovan Effy , Rahim Reanne , Birnbaum Michael L , Yum-Chan Sabrina , Medoff Deborah , Marcogliese Bethany , Fang Lijuan , Nicholson Terriann , Dixon Lisa
Published: October 2021

BACKGROUND

Several studies have shown the benefits of coordinated specialty care (CSC) for individuals with first episode psychosis; however, pathways to care are marred by lack of knowledge, stigma, and difficulties with treatment engagement. Serious games or video interventions may provide a way to address these factors.

OBJECTIVE

This study focuses on qualitative results of a randomized controlled trial comparing OnTrack>The Game (OTG) with recovery videos (RVs) on engagement, stigma, empowerment, hope, recovery, and understanding of psychosis in clients receiving CSC. Clinicians are also interviewed regarding their perceptions of the interventions and suggestions for improvement.

METHODS

A total of 16 clients aged 16-30 years, with first episode psychosis attending a CSC program in New York State, and 9 clinicians participated in the qualitative interviews. Interviews were analyzed using the rapid identification of themes from audio recordings method.

RESULTS

For clients, themes included relatability of game content, an increased sense of hope and the possibility of recovery, decreased self-stigma and public stigma, increased understanding of the importance of social support, and increased empowerment in the OTG group. Clinicians had a preference for RV and provided suggestions for dissemination and implementation.

CONCLUSIONS

Themes that may help inform future research in this area, particularly regarding dissemination and implementation of OTG and RV, emerged.

CLINICALTRIAL

ClinicalTrials.gov NCT03390491; https://clinicaltrials.gov/ct2/show/NCT03390491
A Novel, Scalable Social Media–Based Intervention (“Warna-Warni Waktu”) to Reduce Body Dissatisfaction Among Young Indonesian Women: Protocol for a Parallel Randomized Controlled Trial (Preprint)
Authors: Garbett Kirsty May , Craddock Nadia , Haywood Sharon , Nasution Kholisah , White Paul , Saraswati L Ayu , Medise Bernie Endyarni ,   Girl Effect,   Percolate Galactic, Diedrichs Phillippa C , Williamson Heidi
Published: October 2021

BACKGROUND

Despite the prevalence of body dissatisfaction among young Indonesian women and its consequential negative impacts, there are currently no evidence-based, culturally appropriate interventions to tackle this issue. Therefore, there is a need to develop scalable, cost-effective, and accessible interventions to improve body image among this population.

OBJECTIVE

This paper describes the study protocol of a parallel randomized controlled trial to evaluate the effectiveness of Warna-Warni Waktu, a social media–based intervention that aims to reduce state and trait body dissatisfaction and improve mood among young Indonesian women aged 15-19 years.

METHODS

The trial will take place online. Approximately 1800 young women from 10 cities in Indonesia, evenly split across the ages of 15-19 years, will be recruited via a local research agency’s established research panel. Participants will be randomly allocated to the intervention condition or a waitlist control condition. The intervention consists of six 5-minute videos, with each video supplemented with up to five brief interactive activities. The videos (and associated activities) will be delivered at a rate of one per day across 6 days. All participants will complete three self-report assessments: at baseline (Day 1), 1 day following the intervention (Day 9), and 1 month following the intervention (Day 36). The primary outcome will be change in trait body dissatisfaction. Secondary outcomes include change in internalization of appearance ideals, trait mood, and skin shade satisfaction. Intervention effectiveness on these outcomes will be analyzed using linear mixed models by a statistician blinded to the randomized condition. Intervention participants will also complete state measures of body satisfaction and mood before and after watching each video to assess the immediate impact of each video. This secondary analysis of state measures will be conducted at the within-group level.

RESULTS

Recruitment began in October 2021, with baseline assessments underway shortly thereafter. The results of the study will be submitted for publication in 2022.

CONCLUSIONS

This is the first study to evaluate an eHealth intervention aimed at reducing body dissatisfaction among young Indonesian women. If effective, the intervention will be disseminated to over half a million young women in Indonesia via Facebook, Instagram, and YouTube.

CLINICALTRIAL

ClinicalTrials.gov NCT05023213; https://clinicaltrials.gov/ct2/show/NCT05023213

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/33596
Perceptions of In-home Monitoring Technology for Activities of Daily Living: Semistructured Interview Study With Community-Dwelling Older Adults (Preprint)
Authors: Camp Nicola , Johnston Julie , Lewis Martin G C , Zecca Massimiliano , Di Nuovo Alessandro , Hunter Kirsty , Magistro Daniele
Published: October 2021

BACKGROUND

Many older adults prefer to remain in their own homes for as long as possible. However, there are still questions surrounding how best to ensure that an individual can cope with autonomous living. Technological monitoring systems are an attractive solution; however, there is disagreement regarding activities of daily living (ADL) and the optimal technologies that should be used to monitor them.

OBJECTIVE

This study aimed to understand older adults’ perceptions of important ADL and the types of technologies they would be willing to use within their own homes.

METHODS

Semistructured interviews were conducted on the web with 32 UK adults, divided equally into a younger group (aged 55-69 years) and an older group (≥70 years).

RESULTS

Both groups agreed that ADL related to personal hygiene and feeding were the most important and highlighted the value of socializing. The older group considered several activities to be more important than their younger counterparts, including stair use and foot care. The older group had less existing knowledge of monitoring technology but was more willing to accept wearable sensors than the younger group. The younger group preferred sensors placed within the home but highlighted that they would not have them until they felt that daily life was becoming a struggle.

CONCLUSIONS

Overall, technological monitoring systems were perceived as an acceptable method for monitoring ADL. However, developers and carers must be aware that individuals may express differences in their willingness to engage with certain types of technology depending on their age and circumstances.
Effectiveness of Mindfulness-Based Cognitive Therapy With Follow-Up Sessions for Pharmacotherapy-Refractory Anxiety Disorders: Protocol for a Feasibility Randomized Controlled Trial (Preprint)
Authors: Sado Mitsuhiro , Ninomiya Akira , Nagaoka Maki , Koreki Akihiro , Goto Naho , Sasaki Yohei , Takamori Chie , Kosugi Teppei , Yamada Masashi , Park Sunre , Sato Yasunori , Fujisawa Daisuke , Nakagawa Atsuo , Mimura Masaru
Published: October 2021

BACKGROUND

Augmented mindfulness-based cognitive therapy (MBCT) with treatment as usual (mainly pharmacotherapy) is reported to be effective after treatment for anxiety disorders. However, whether its effectiveness persists in the long term is unclear.

OBJECTIVE

This study aims to examine the feasibility, acceptability, and effectiveness of a follow-up program by conducting a feasibility randomized controlled trial (RCT) that compares augmented MBCT with follow-up sessions and that without follow-up sessions in preparation for a definitive RCT.

METHODS

The study involves an 8-week MBCT with a 10-month follow-up. Patients aged 20 to 65 years who meet the Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) criteria for panic disorder, agoraphobia, or social anxiety disorder, which is not remitted with usual treatment for at least 4 weeks, will be included in the study and randomly allocated to receive augmented MBCT with follow-up sessions or augmented MBCT without follow-up sessions. For this feasibility RCT, the primary outcomes are (1) study inclusion rate, (2) dropout rate, (3) attendance rate, and (4) mean and standard deviation of several clinical measures at 8 weeks and 5, 8, and 12 months.

RESULTS

We started recruiting participants in January 2020, and 43 participants have been enrolled up to January 2021. The study is ongoing, and data collection will be completed by May 2022.

CONCLUSIONS

This study is novel in terms of its design, which compares augmented MBCT with and without follow-up sessions. The limitations of the trial are as follows: (1) mixed participants in terms of the delivery mode of the intervention, and (2) lack of a pharmacotherapy-alone arm. Owing to its novelty and significance, this study will provide fruitful knowledge for future definitive RCTs.

CLINICALTRIAL

UMIN Clinical Trials Registry UMIN000038626; https://tinyurl.com/2p9dtxzh

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/33776
Correction: Electronic Video Consent to Power Precision Health Research: A Pilot Cohort Study (Preprint)
Authors: Naeim Arash , Dry Sarah , Elashoff David , Xie Zhuoer , Petruse Antonia , Magyar Clara , Johansen Liliana , Werre Gabriela , Lajonchere Clara , Wenger Neil
Published: October 2021

UNSTRUCTURED

Developing innovative, efficient, and institutionally scalable biospecimen consent for remnant tissue that meets the National Institutes of Health consent guidelines for genomic and molecular analysis is essential for precision medicine efforts in cancer. This study aims to pilot-test an electronic video consent that individuals could complete largely on their own. The University of California, Los Angeles developed a video consenting approach designed to be comprehensive yet fast (around 5 minutes) for providing universal consent for remnant biospecimen collection for research. The approach was piloted in 175 patients who were coming in for routine services in laboratory medicine, radiology, oncology, and hospital admissions. The pilot yielded 164 completed postconsent surveys. The pilot assessed the usefulness, ease, and trustworthiness of the video consent. In addition, we explored drivers for opting in or opting out. The pilot demonstrated that the electronic video consent was well received by patients, with high scores for usefulness, ease, and trustworthiness even among patients that opted out of participation. The revised more animated video pilot test in phase 2 was better received in terms of ease of use (P=.005) and the ability to understand the information (P<.001). There were significant differences between those who opted in and opted out in their beliefs concerning the usefulness of tissue, trusting researchers, the importance of contributing to science, and privacy risk (P<.001). The results showed that “I trust researchers to use leftover biological specimens to promote the public's health” and “Sharing a biological sample for research is safe because of the privacy protections in place” discriminated opt-in statuses were the strongest predictors (both areas under the curve were 0.88). Privacy concerns seemed universal in individuals who opted out. Efforts to better educate the community may be needed to help overcome some of the barriers in engaging individuals to participate in precision health initiatives.
Correction: Precision Public Health Campaign: Delivering Persuasive Messages to Relevant Segments Through Targeted Advertisements on Social Media (Preprint)
Authors: An Jisun , Kwak Haewoon , Qureshi Hanya M , Weber Ingmar
Published: October 2021

UNSTRUCTURED

REMOVE
Exploring Relationships Between Tweet Numbers and Over-the-counter Drug Sales for Allergic Rhinitis: Retrospective Analysis (Preprint)
Authors: Wakamiya Shoko , Morimoto Osamu , Omichi Katsuhiro , Hara Hideyuki , Kawase Ichiro , Koshiba Ryuji , Aramaki Eiji
Published: October 2021

BACKGROUND

Health-related social media data are increasingly being used in disease surveillance studies. In particular, surveillance of infectious diseases such as influenza has demonstrated high correlations between the number of social media posts mentioning the disease and the number of patients who went to the hospital and were diagnosed with the disease. However, the prevalence of some diseases, such as allergic rhinitis, cannot be estimated based on the number of patients alone. Specifically, individuals with allergic rhinitis typically self-medicate by taking over-the-counter (OTC) medications without going to the hospital. Although allergic rhinitis is not a life-threatening disease, it represents a major social problem because it reduces people’s quality of life, making it essential to understand its prevalence and people’s motives for self-medication behavior.

OBJECTIVE

This study aims to explore the relationship between the number of social media posts mentioning the main symptoms of allergic rhinitis and the sales volume of OTC rhinitis medications in Japan.

METHODS

We collected tweets over 4 years (from 2017 to 2020) that included keywords corresponding to the main nasal symptoms of allergic rhinitis: “sneezing,” “runny nose,” and “stuffy nose.” We also obtained the sales volume of OTC drugs, including oral medications and nasal sprays, for the same period. We then calculated the Pearson correlation coefficient between time series data on the number of tweets per week and time series data on the sales volume of OTC drugs per week.

RESULTS

The results showed a much higher correlation (r=0.8432) between the time series data on the number of tweets mentioning “stuffy nose” and the time series data on the sales volume of nasal sprays than for the other two symptoms. There was also a high correlation (r=0.9317) between the seasonal components of these time series data.

CONCLUSIONS

We investigated the relationships between social media data and behavioral patterns, such as OTC drug sales volume. Exploring these relationships can help us understand the prevalence of allergic rhinitis and the motives for self-care treatment using social media data, which would be useful as a marketing indicator to reduce the number of out-of-stocks in stores, provide (sell) rhinitis medicines to consumers in a stable manner, and reduce the loss of sales opportunities. In the future, in-depth investigations are required to estimate sales volume using social media data, and future research could investigate other diseases and countries.
Vascular flow simulations using SimVascular and OpenFOAM (Preprint)
Authors: Yogeswaran Swetha , Liu Fei
Published: October 2021

UNSTRUCTURED

Applications of computational fluid dynamics (CFD) techniques to aid in the diagnosis and treatment of cardiovascular disease have entered the research domain in recent years, due to their ability to provide valuable patient-specific information without risks associated with highly invasive procedures. SimVascular is an open-source software which allows streamlined processing and CFD blood flow analysis of medical imaging data. OpenFOAM is a proven open-source software which allows for versatile modeling of various fluid dynamics phenomena. In this study, both SimVascular and OpenFOAM simulations are set up with identical computational mesh, similar numerical schemes, boundary conditions, and material properties, to model blood flow in the coronary artery of a 10 year old patient with Coarctation of the Aorta (CoA) who underwent end-to-side anastomosis. Difference in the flow fields such as flow rate, pressure, vorticity, and wall shear stress between SimVascular and OpenFOAM are analyzed. Similar results are obtained in both simulations up to a certain model time, before the results become drastically different. Both the similarities and differences are documented and discussed.
Empowering Family Awareness of Cardiovascular Disease in Ngangkrik Hamlet, Sleman Regency
Authors: Nurrahma Erinda , Widyadhana Ailsa Nur Rahma Apta , Saraswati Annisa Leny , Anugraheni Ave , Prasetyatama Muhammad Jourdan , Huriyati Emy
Published: October 2021

Cardiovascular disease is the main cause of death worldwide and in Indonesia. Public awareness and acceptance of preventative cardiovascular care are crucial for reducing illness-related morbidity and mortality. As a result, community service is essential for the primary prevention of cardiovascular disease. Between April and July 2019, this community service was undertaken in Ngangkrik Hamlet, Sleman Regency, Yogyakarta Special Region (DIY). Ngangkrik locals participated in this program in three categories: Bapak Bijak (Wise Dads), Ibu Cerdas (Smart Moms), and Pemuda Bijak (Wise Youngsters). Five stages comprised this program: planning, informing, preparation, implementation, and oversight. Lectures/courses, discussions, practice, and roleplaying were used to implement the materials. To examine participants' knowledge, the pretest and posttest approach was utilized. The program raised participants' knowledge and understanding about the prevention and treatment of cardiovascular disease across all categories.
Bajo el signo de Orfeo: duelo, melancolía y castración del héroe decadente
Authors: Chaves José Ricardo
Published: October 2021

José Ricardo Chaves examina el héroe decadente: sus orígenes, su evolución y su representación final en la literatura finisecular decimonónica. A la marginación social que sufre el artista en la sociedad burguesa del XIX, hay que añadir una cierta marginación sexual que él mismo se encarga de producir en la escena literaria con personajes que hacen del sexo una vía de trascendencia más allá del matrimonio burgués, como los viajes a tierras exóticas, como las drogas, como la magia y el ocultismo, que tanta importancia tuvieron en la imaginación artificialista, decadente y desencantada. Orfeo describe la percepción que tenían de sí mismos los hombres al final del siglo XIX: han perdido para siempre a su Eurídice ideal y en su duelo melancólico y narcisista han llegado a desear a su propio sexo y a temer a las mujeres sexuales que merodean y que amenazan con castrarlo.
Prediction of Crop, Fertilizer and Disease Detection for Precision Agriculture
Authors: C Bharathi
Published: October 2021

Abstract: The main walk of life of our Country is Agriculture. More than 70 % of the population’s lives depend upon agriculture. It is also a great source of country’s economy. In order to make this filed more profitable for farmers proper crops have to be grown in their fields. The prevalent problem among the farmers is Crop choice depending upon the soil in their farmlands. Another challenge faced by farmers is choosing the right fertilisers for their crops, which plays a very important role in getting a good and profitable yield. There is another major problem which they have to give more attention is the pest control or the diseases to which the plants may limit their growth. The above listed problems may solved using the advanced techniques of Precision Agriculture and data mining. Precision Agriculture is modern technique which can be used for farming. The main objective of is to solve above problems using data mining techniques and build a decision system which would help farmers to choose right crops for their farm , fertiliser recommendation for the crops grown and also to help the farmers in detecting the diseases by using the infected leaf images.. Keywords: Precision Agriculture, Data Mining, Crop, fertilizer recommendation system, ML Algorithms
Effect of barren plateaus on gradient-free optimization
Authors: Arrasmith Andrew , Cerezo M. , Czarnik Piotr , Cincio Lukasz , Coles Patrick J.
Published: October 2021

Barren plateau landscapes correspond to gradients that vanish exponentially in the number of qubits. Such landscapes have been demonstrated for variational quantum algorithms and quantum neural networks with either deep circuits or global cost functions. For obvious reasons, it is expected that gradient-based optimizers will be significantly affected by barren plateaus. However, whether or not gradient-free optimizers are impacted is a topic of debate, with some arguing that gradient-free approaches are unaffected by barren plateaus. Here we show that, indeed, gradient-free optimizers do not solve the barren plateau problem. Our main result proves that cost function differences, which are the basis for making decisions in a gradient-free optimization, are exponentially suppressed in a barren plateau. Hence, without exponential precision, gradient-free optimizers will not make progress in the optimization. We numerically confirm this by training in a barren plateau with several gradient-free optimizers (Nelder-Mead, Powell, and COBYLA algorithms), and show that the numbers of shots required in the optimization grows exponentially with the number of qubits.
Investment cooperation between Russia and India
Authors: Manshin Roman V. , Ghafari Abdul Latif
Published: October 2021

The long-term cooperation between Russia and India in the investment field is analyzed. This cooperation is of great strategic importance not only for the development of these countries, but also for solving problems at the global level. The world is currently undergoing large-scale changes affecting various spheres of public life. On the basis of Russian and Indian statistics, as well as statistics of international organizations, conclusions are drawn about the uneven distribution of foreign direct investment between Russia and India, and their different position in the international movement of capital is indicated. Examples of specific investment projects between TNCs of the two countries are given. Prospects for investment cooperation between the two countries have been substantiated. The purpose of this research is to study investment cooperation between Russia and India. The theoretical basis of the study was the works of Russian and foreign authors, which examine the issues of the socio-economic situation of developing countries, and in particular, the economic development of India and Russian-Indian relations. The work used methods of analysis and comparison of theoretical positions, as well as methods of statistical and analogy, expert assessments. It was found that the most interesting projects for the Indian economy are the extraction of oil and other minerals, construction, trade, and real estate. For Russia, the sphere of manufacturing is of particular investment interest, as well as the sphere of trade and the financial sector.
Mali’s participation in the West Africa’s integration processes
Authors: Andronova Inna V. , Dembele Mama
Published: October 2021

The first ever integration bloc in Africa was formed back in the colonial era in 1910, when a number of British colonies were integrated. Modern integration processes in the African countries in the south of the Sahara began much later, from the early 1960s, when most of the former colonies gained independence, and it was during this period that the construction of a number of economic blocks began. The article reveals integration processes in West Africa and sub-Saharan African countries features. Integration as such is viewed as a complex procedure, with the success way which depends on many factors. On the experience of the Republic of Mali, the authors demonstrated how an irrational socio-economic policy can lead to deformation of integration processes, which inevitably threatens with deep financial and socio-political crises.
What’s happening to the locomotive of global economy, or The myths about the recovery of China
Authors: Reshetnikova Marina S. , Pugacheva Irina A.
Published: October 2021

The COVID-19 pandemic has caused irreparable damage to all economies. Coping with the consequences by the leading players in the global economy is only expected. However, the worlds leading organizations have been trumpeting about overcoming the crisis in China. The aim of the research is to analyze the current state of the Chinese economy and answer the question whether it has overcome all the crisis phenomena. As part of the study, the authors analyzed indicators such as GDP, debt level, level of domestic demand, activity in the financial market and the MA market, as well as technological and social policies of China and the structure of trade. For the analysis of quantitative indicators, a combination of comparison and classification methods, media scanning, and crowdsourcing was used. The information base was grounded on annual reference books published by official institutions in Сhina, World Bank, International Monetary Fund, statistical data from international publications devoted to Chinese economy. The analysis showed the presence of trigger situations in the stock market, in the market for innovative investments and the banking sector. The state of the credit system is also a matter of concern. The authors have proven that enthusiastic statements about the rapid recovery of the Chinese economy are more an encouraging myth than a fait accompli. Today, China is only at the beginning of its recovery from the crisis caused by the pandemic. Will it be able to become the locomotive of global economic growth again, as in 2008? The answer to this question remains open.
Antidiabetic Activity of Peperomia pellucida In Streptozotocin-Induced Diabetic Mice
Authors: Hidayati Sholihatil
Published: October 2021

Background: Diabetes mellitus is a heterogeneous group of diseases in the form of disorders in the body's metabolism clinically. Peperomia pellucida herbs have phytochemical containing which is antidiabetic potential development. Objectives: This study was conducted to compare the antidiabetic activity of ethanol extract and n-hexane fraction of Peperomia pellucida. Material and Methods: This research was conducted by make diabetic mice with 50 mg/kg.bw of streptozotocin induction, which was then treated with ethanol extract and n-hexane fraction of Peperomia pellucida with doses 250 mg/kgbw for 7 days.  Results: The results showed that the ethanol extract and n-hexane fraction of Peperomia pellucida reduced blood glucose levels in diabetic mice due to streptozotocin induction. The n-hexane fraction of Peperomia pellucida can lower blood glucose levels as much 244.00 ± 18.99 mg/dL better than the ethanol extract, which is 99.50 ± 28.17 mg/dL. Conclusions: Peperomia pellucida herb has the potential to be developed as an antidiabetic agent.
The Evaluation of Fasting Plasma Glucose (FPG) Levels in Hypertensive Patients Using Calcium Channel Blocker (CCB) Drugs Class in Undata Regional Hospital
Authors: Rumi Amelia , Fitriana Anggun
Published: October 2021

Background: Hypertension plays a major role in the development of heart disease which is one of the most leading causes of death worldwide. Antihypertensives must be selected carefully to avoid affecting metabolic parameters. A risky case involving the increase of plasma glucose levels using Calcium Channel Blocker (CCB) antihypertensive, amlodipine, has been reported. Objectives: This study aims to examine the effects of CCB treatments on blood glucose levels in hypertensive patients at the Undata District General Hospital of Central Sulawesi Province. Material and Methods: This study used a cross-sectional design with a prospective approach. The instruments & materials used in this study are Accu-Chek Performa glucometer along with the patient's blood sample material. The research subjects were 31 patients who met the inclusion criteria; patients had been treated with CCB therapy for 3 months, patients were not diagnosed with diabetes mellitus, andpatients did not use drugs that might affect the blood glucose levels. Results: The results showed an average value of fasting plasma glucose (FPG) levels of hypertension patients using CCB class showed an increase from baseline of 124,619 mg/dL to 141,612 mg/dL with a difference of 16,993 mg/dL. Statistical analysis conducted also obtained a significance value of p 0,000 which indicates that the use of amlodipine can significantly increase fasting patients' plasma glucose levels. Conclusions: If observed clinically, the increasing in fasting plasma glucose values ​​falls into the category of mild to moderate hyperglycemic.