bluuebunny/crossref_metadata_2025 huggingface dataset:
KIF18A is a novel target of JNK1/c-Jun signaling pathway involved in tumorigenesis
Authors: Wang Yajie , Yu Siqi , Huang Baihai , Zhou Bowen , Wu Xinyue , Lian Xiaoying , Wen Lianpu , Zhu Changjun
Published: February 2024

Background
The mitogen-activated protein kinases (MAPKs) play a crucial role in various cellular processes, including gene expression. Among these, MAPK, MAPK8 (JNK1) specifically activates the oncogene—c-Jun. KIF18A, a kinesin protein, functions both as a promoter and an inhibitor of microtubule dynamics. Aberrant expression of KIF18A is linked with tumorigenesis, but its involvement in the JNK1/c-Jun pathway remains unclear. This study investigates the regulatory relationship between KIF18A and the JNK1-c-Jun pathway in cervical cancer.
Methods
We utilized the Genomic Data Commons (GDC) data portal to screen for KIF18A-related protein kinases in cervical cancer. All mRNA expression data of all cancer types obtained from TCGA database was investigated to further confirm the correlation between JNK1 and KIF18A. Expression levels of pc-Jun, c-Jun and KIF18A were examined through western blotting (WB) after inhibition of JNK1 in HeLa cells. In silico analysis was performed to identify the TF binding motifs on KIF18A promoter. Chromatin immunoprecipitation (ChIP) assay and Luciferase assay were used to confirm the c-Jun's direct binding and activation of the KIF18A promoter. Effect of c-Jun/KIF18A on cell growth was assessed by MTT assay and colony assay.
Results
A total of 193 kinases exhibited a close correlation with KIF18A, with JNK1 displaying a notably high correlation in cervical cancer and other tumor types. Inhibition of JNK1 in HeLa cells resulted in reduced KIF18A expression and decreased phosphorylation of c-Jun. Through In-silico analysis, c-Jun was identified as a transcription factor (TF) capable of binding to the KIF18A promoter. Confirmatory ChIP and Luciferase assays established c-Jun's direct binding and activation of the KIF18A promoter. Knockdown of c-Jun inhibited cancer cell proliferation by suppressing KIF18A transcription.
Conclusions
In summary, the JNK1/c-Jun pathway activates KIF18A expression, a process essential for cervical cancer cell proliferation. Targeting the JNK/c-Jun/KIF18A axis holds promise as a novel therapeutic approach in cancer treatment.
WITHDRAWN: Harmonizing Sustainable Transportation: A Comprehensive Hybrid Vehicle Integrating CNG, In-Wheel Motors, and Rooftop Solar Panels for Environmental Excellence.
Authors: KARTHIK MURI
Published: February 2024

This research paper presents a novel approach to sustainable transportation by proposing a hybrid vehicle that integrates a compressed natural gas (CNG) engine with a battery-powered plug-in electric vehicle (BEV). The hybrid system incorporates in-wheel motors for enhanced efficiency and maneuverability, coupled with a rooftop solar panel system to supplement energy supply. The integration of CNG and electric power addresses range anxiety associated with electric vehicles, reduces emissions, and promotes cleaner air quality. In-wheel motors optimize torque control and regenerative braking, while the rooftop solar panels extend the vehicle's driving range, reducing dependence on the grid. This comprehensive approach offers a promising solution for sustainable transportation, aligning with environmental goals and advancing clean energy technologies in the automotive sector
Investigating post-traumatic stress disorder among internally displaced undergraduate students in tribal districts of Pakistan
Authors: Cao Shan , Hussain Mudassir , Ullah Mati
Published: February 2024

The main focus of the researcher in this study was to investigate the Post-Traumatic Stress Disorder (PTSD) among Internally Displaced Undergraduate Students in Tribal Districts of Pakistan. The total number of (N = 220, respondents (IDPs undergraduate students) in six universities of Khyber Pakhtunkhwa (UST Bannu, KUST, Kohat, Gomal University, University of Peshawar, Swat University, and Malakand University) were the population of the study in which (n = 140 respondents: (20 undergraduate students) from each Tribal District (North Waaziristan South Waziristan, Orakzai, Bajaur, Kurram, Khyber and Mohmand) in the selected universities were taken as sample of the study by applying Krejcie, R.V., & Morgan, D.W. (1970) sample size formula. Simple random sampling and stratified sampling techniques were used. The key purpose of the study was to investigate the Post-Traumatic Stress Disorder among IDPs Undergraduate Students in Tribal Districts of Pakistan. Data were taken through a face-to-face questionnaire on a 3-point scale with options much affected, more affected, and most affected for quantitative purposes while interviews were taken from the respondents for qualitative purposes. The collected data were recorded and statistically analyzed through SPSS by using frequency, percentage, and Chi-Square tests. Results and conclusions were drawn by revealing that PTSD negatively affected IDPs Undergraduate students. Some recommendations were suggested that the government may give priority to discouraging and stopping war hazards in tribal districts of Pakistan by establishing psychological, medical, and psychiatric corners in each tribal district to ensure better treatment of PTSD patients.
Hepatitis E Infection and the Question of Screening Organ Donors
Authors: Solignac Justine , Boschi Celine , Pernin Vincent , Fouilloux Virginie , Motte Anne , Aherfi Sarah , Aubrespy Maxime Fabre - , Legris Tristan , Brunet Philippe Brunet , Colson Philippe , Moal Valérie
Published: February 2024

Background
Hepatitis E is a potentially serious infection in organ recipients, with an estimated two-thirds of cases becoming chronic, and with a subsequent risk of cirrhosis and death. In Europe, transmission occurs most often through the consumption of raw or undercooked pork, more rarely through blood transfusion, but also after solid organ transplantation. Here we describe a case of Hepatitis E virus (HEV) infection transmitted following kidney transplantation and review the literature describing cases of HEV infection transmitted by solid organ transplantation.
Case presentation
Three weeks after kidney transplantation, the patient presented with an isolated minimal increase in GGT and hepatic cytolysis 6 months later, leading to the diagnosis of genotype 3c hepatitis E, with a plasma viral load of 6.5 log10IU/mL. In retrospect, HEV RNA was detected in the patient's serum from the onset of hepatitis, and in the donor's serum on the day of donation, with 100% identity between the viral sequences, confirming donor-derived HEV infection. Hepatitis E had a chronic course, was treated by ribavirin, and relapsed 10 months after the end of treatment.
Conclusions
Seven cases of transmission of HEV by solid organ transplantation have been described since 2012 without systematic screening for donors, all diagnosed at the chronic infection stage; two patients died. HEV organ donor transmission may be underestimated and there is insufficient focus on immunocompromised patients in whom mild liver function test impairment is potentially related to hepatitis E. However, since HEV infection is potentially severe in these patients, and as evidence accumulates, we believe that systematic screening of organ donors should be implemented for deceased and living donors regardless of liver function abnormalities, as is already the case in the UK and Spain. In January 2024, the French regulatory agency of transplantation has implemented mandatory screening of organ donors for HEV RNA.
Analysis on temporal variability of monsoon rainfall using ARIMA Model and ANN-LSTM
Authors: Grover Rahul , Sharma Siddhartha , Bajaj Pankaj
Published: February 2024

In this study, machine learning algorithms employed for predicting the weather conditions of the upcoming day with a particular focus on forecasting rain, which serves as a crucial indicator. To identify the most reliable rain-related attributes, most of the researchers utilize line charts, matrix graphs, and scatterplot graphs for visualization and analysis. The investigation reveals several attribute pairs demonstrating a significant degree of similarity and correlation. In the modeling phase, researchers employ elementary models such as decision trees, and regression analysis to assess their fundamental prediction capabilities. The resulting accuracy rate found favourable sometimes on statistics platform. Notably, during the visualization stage, a subtle pattern emerges: samples experiencing rainfall today exhibit a slightly elevated probability of rain the following day. Temporal variability in rainfall refers to the fluctuations and changes in precipitation patterns over time. It encompasses the temporal distribution, intensity, and duration of rainfall events, reflecting the dynamic nature of weather systems. Understanding temporal variability is crucial for effective water resource management, agriculture, and climate impact assessment. Consequently, our attempt to analyze the influence of historical weather on forecasting using ARIMA and ANN-LSTM. The rainfall predictions generated by these models are deemed accurate based on statistical analysis and algorithm simulation.
Tuning the ground state of cuprate high-critical-temperature superconducting thin films by nanofaceted substrates
Authors: Seibold Goetz , Arpaia Riccardo , Wahlberg Eric , Bauch Thilo , Kalaboukhov Alexei , Caprara Sergio , Castro Carlo Di , Grilli Marco , Lombardi Floriana , Mirarchi Giovanni
Published: February 2024

Anisotropic transport properties have been assessed in a number of cuprate superconductors, providing evidence for a nematic state. In our recent experiment we have shown that for ultra- thin YBa2Cu3O7-δ (YBCO) films, where nematicity is induced via strain engineering, there is a suppression of charge density wave scattering along the orthorhombic a-axis and a concomitant enhancement of strange metal behavior along the b-axis~. Here we develop a microscopic model, that is based on the strong interaction between the substrate facets and the thin film, to account for the unconventional phenomenology. Based on the atomic force microscopy imaging of the substrates’ surface, the model is able to predict the absence (presence) of nematicity and the resulting transport properties in films grown on SrTiO3 (MgO) substrates. Our result paves the way to new tuning capabilities of the ground state of HTS by substrate engineering.
Factors Associated with Changes in Reproductive Outcomes during the first year of COVID- 19 pandemic in Burkina Faso: A multinomial analysis from a longitudinal study using PMA 2030 data
Authors: Sylvain Y. M. , Joseph Ashaolu
Published: February 2024

Background:The advent of COVID-19 pandemic has dramatically affected women’s life and livelihoods. In the past decade, the promotion of family planning contributed to reduced poverty and averted poor maternal and child outcomes. There is evidence that these gains may be threatened by social restrictions following COVID-19 outbreak.
Methods:We used data from a longitudinal survey collected by the Performance Monitoring Accountability in Burkina Faso. Data were collected over one-year period, from before (November 2019–February 2020) and during (November 2020–February 2021) COVID-19 pandemic. We evaluate changes in reproductive outcomes with respect to changes in health and economic circumstances as well as sociodemographic conditions among 1372 women aged 15-49 at risk of pregnancy and potential contraceptive users. Bivariate and multivariate multinomial logistic regression were performed to examine correlates of reproductive outcomes.
Results:Half (52%) of women did not change their reproductive status. While, 29% had childbearing, 19% started using a contraceptive method. In the multivariate analysis, childbearing was relatively higher among women exposed to family planning promotion, healthcare utilization, but relatively lower among those employed without cash paid and those who experienced household income loss. As of contraception, women exposed to family planning promotion were also associated with a relatively higher contraceptive use while concerns about getting COVID-19 infection had the opposite effect.
Conclusion:After a year period of COVID-19 outbreak, contraceptive adoption increased significantly, but at a slower pace which was not enough to reduce childbearing. The most vulnerable women may remain at greater risk of unintended pregnancies and poor maternal and child outcomes. Therefore, family planning programs should direct their efforts into combatting misinformation and reaching out women in communities in the context of COVID-19 restrictions.
Co-designing a cardiac rehabilitation program with knowledge users for patients with cardiovascular disease from a remote area
Authors: Bernier Jessica , Breton Mylaine , Poitras Marie-Eve
Published: February 2024

Background: Cardiovascular disease is the leading cause of death worldwide. Cardiac rehabilitation (CR) programs are recognized as effective in reducing the burden of cardiovascular disease. However, cardiac rehabilitation programs are offered inequitably across regions, and are available in less than 15% of remote areas worldwide. The main goal of this study was to design a CR program adapted to the contexts of remote areas, in order to improve the service offer for patients.
Methods: We used an iterative user-centered design approach to understand the user context and services offered in cardiac rehabilitation in remote areas. We conducted two co-design processes in two remote regions with knowledge users. Two advisory committees were created in each of these regions, comprising managers (n = 6), healthcare professionals (n = 12) and patients (n = 2). We used the guidelines of an operational model specific to cardiac rehabilitation to conceptualize data collection for the development of the cardiac rehabilitation program. We conducted four cycles of co-design with each of the committees to develop the cardiac rehabilitation program. Qualitative data were analyzed iteratively after each cycle.
Results: The co-design process led to the development of a prototype cardiac rehabilitation program that is similar in both regions, based on a six-phase care and service trajectory contextualized to remote regions. Participants made structural changes to phases 0, 2, 3 and 4 in order to overcome staffing shortages in remote areas. These changes make it possible to decentralize cardiac rehabilitation expertise away from specialized centers, to ensure equity of service across the territory. Therapeutic patient education was integrated into phase 4 to meet patients' needs. Participants suggested that three follow-up offerings could come from nursing services to increase access to the cardiac rehabilitation program (primary care, home care, special chronic disease programs) in patients' home communities.
Conclusion: The co-design process enables us to meet the needs of remote regions in program development. This final program can be the subject of future implementation research.
Blockchain for IoT and Medical Data Management
Authors: El-Hamed Osama M. Abd , El-Samie Fathi E. Abd , Badawy Wael , El-atty Saied M. Abd
Published: February 2024

This paper presents an innovative approach to enhance the security, sharing, and management of medical data in hospitals and clinics through the integration of blockchain technology and Internet of Things (IoT) devices. Traditional databases, while effective, may pose challenges related to data security and accessibility. In response, our proposed system leverages the inherent features of blockchain to establish a tamper-resistant and transparent framework for storing medical records. The core of our solution involves the integration of blockchain in medical data storage, utilizing Raspberry Pi devices equipped with sensors such as DHT11 for data collection. Each patient is uniquely identified and assigned an individualized ID number, acting as a secure password to access and manage their medical records. This not only ensures data privacy but also provides a seamless and secure method for patients to oversee their healthcare information. We propose a partially decentralized blockchain-based system for medical data storage, constructed from scratch using TypeScript. Additionally, we provide a proof of concept that demonstrates the practical implementation of blockchain in the realm of Electronic Health Records (EHR), utilizing a temperature sensor (DHT11) connected to a Raspberry Pi specifically designed for IoT medical records systems. This multifaceted approach contributes to advancing the field by offering a secure, transparent, and patient-centric system for healthcare data management.
The Course of Moderate-to-Severe Headaches in Patients Undergoing Endovascular Treatment for Unruptured Intracranial Aneurysms: A retrospective cross-sectional Study
Authors: Choi Jin Young , Kim Young Bae , Chung Joonho , Park Keun Young , Han Hyun Jin , Kim Junhyung , Park Sang Kyu
Published: February 2024

Background
This retrospective cross-sectional study aimed to investigate the course of newly onset moderate-to-severe headaches in patients who underwent endovascular treatment (EVT) for unruptured intracranial aneurysms (UIAs).
Methods
Between September 2009 and May 2022, 412 patients were included, and all met the following criteria: (1) presence of UIAs on computed tomography angiography or magnetic resonance angiography; (2) newly onset moderate-to-severe headache (Numeric Rating Scale, NRS ≥ 4) around the time of UIAs diagnosis; and (3) EVT of UIAs. We evaluated initial and follow-up NRS scores to determine the significance of NRS changes and identified predisposing factors for headache improvement at the 12-month follow-up.
Results
Compared to the NRS score before EVT, the average NRS scores significantly decreased at discharge (P < 0.05). Subsequently, the follow-up NRS scores at 1-month, 6-month, and 12-month were significantly decreased (P < 0.01). Follow-up NRS scores decreased continuously until the 12-month follow-up. In multiple logistic regression analysis, a history of stroke (odds ratio [OR] = 0.539, 95% confidence interval [CI] 0.196 to 0.806; P = 0.039) and procedure-related complications (OR = 0.567, 95% CI 0.218 to 0.728; P = 0.045) were identified as independent predisposing factors of headache improvement.
Conclusions
After EVT of UIAs, patients with newly onset moderate-to-severe headaches experienced significant headache improvement at discharge, with NRS scores continuously decreasing over the 12 months of follow-up. Headache improvement might be expected in patients who do not have a history of stroke and in those who have not experienced procedure-related complications.
Applicability of the pipe-model theory to seedlings of hinoki cypress (Chamaecyparis obtusa)
Authors: Ogawa Kazuharu
Published: February 2024

According to the pipe-model theory, the relationship between the cumulative mass of leaves [F(z)] and the density of non-photosynthetic organs [C(z)] at depth z from the crown surface is linear for adult trees. However, the present study of seedlings of Chamaecyparis obtusa demonstrates that the F(z)–C(z) relationship can be approximated as a non-rectangular hyperbola with convexity (θ) between 0 and 1. For θ=1, the F(z)–C(z) relationship is linear, in accordance with adult trees. Therefore, the basic concept of pipe-model theory regarding the F(z)–C(z) relationship can be generalized as a non-rectangular hyperbola for both growth stages (i.e., seedlings and adult trees). The difference between linearity (θ = 1) and curvilinearity \(\left(\theta \ne 1\right)\)in the F(z)–C(z) relationship corresponds to the difference in proportional area of sapwood in the studied seedlings. Thus, the proportional sapwood area is larger for seedlings with a linear F(z)–C(z) relationship than for seedlings with a curvilinear F(z)–C(z) relationship. The relationship between convexity and the square of stem diameter at the crown base showed scatter in terms of both season and seedling size, indicating that the size dependence of the degree of curvature in the F(z)–C(z) relationship for seedlings remains unclear. The allometric relationship between leaf mass and the square of stem diameter at crown base tended to separate seedlings from adult trees. Seedlings have more leaves per stem cross-sectional area at crown base than adult trees, as seedling stems are mostly composed of sapwood, which functions as an assemblage of living pipes connected to the leaves. Greater scattering of data for seedlings than adult trees in the allometry between leaf mass and the square of stem diameter at crown base could be explained by the non-rectangular hyperbola of the F(z)–C(z) relationship.
Differentially expressed genes and ceRNA network of early subperiosteal osteogenesis in rabbit skull defect models
Authors: Wang Wenxue , Zhao Baodong , Xu Hao , Zhen Li , Li Xin
Published: February 2024

Objective
To explore potential critical genes and identify ceRNA network participating in early stage of subperiosteal osteogenesis.
Materials and Methods
Rabbit skull defect models were constructed. The periosteum of defects and control site were obtained 3 weeks postsurgery, and a bioinformatics method was used to analyze differentially expressed (DE) genes and construct a ceRNA regulatory network.
Results
In total, 332 lncRNAs, 22 circRNAs, 37 miRNAs and 1141 mRNAs were differentially expressed. The functional enrichment suggested the immune response, cell-cell interaction, cell proliferation and differentiation, and angiogenesis were associated with wound healing and osteogenesis at an earlier stage. CeRNA networks with 39 lncRNA/ 33 miRNAs/ 51mRNAs and 8 circRNAs/ 9 miRNAs/ 46 mRNAs. were constructed respetively.
Conclusion
Expression gene profiles were significantly altered in periosteum during early healing stages of bone regeneration. This study revealed potentially important genes, pathways and ceRNA regulatory networks participating in intramembranous osteogenesis.
Anatomical Description of the Brachial Plexus Nerves in Sphiggurus Villosus (Cuvier, 1823) (Rodentia: Erethizontidae): A Comparative Analisys
Authors: Estruc¹ Thais Mattos , Nascimento¹ Renata Medeiros , Carvalho² Natan Cruz , Santos-Sousa³ Carlos Augusto , Souza-Júnior² Paulo , Abidu-Figueiredo¹ Marcelo
Published: February 2024

The aim of this study was to describe the origin and branches of the brachial plexus nerves in S. villosus, as well as the innervated musculature, contributing information to the field of comparative animal anatomy and providing insights for applied studies. Fifteen adult cadavers (eight males and seven females), previously identified, sexed, and fixed with a 10% aqueous formaldehyde solution, were used. They underwent digital radiographic examinations of the cervical region to characterize the number of cervical vertebrae. The nerves were dissected up to the innervation of the intrinsic and extrinsic musculature of the thoracic limb. With the assistance of a costotome, the vertebrae were removed until the visualization of the spinal cord and the roots giving rise to the nerve branches. The specimens presented seven cervical vertebrae, and the brachial plexus was characterized as post-fixed, formed by connections between the last four cervical spinal nerves (C5, C6, C7, and C8) and the first two thoracic nerves (T1 and T2). The cranial, middle, and caudal trunks originated the suprascapularis, subscapularis, axillary, musculocutaneous, radial, median, and ulnar nerves for intrinsic musculature, and the cranial pectoral, caudal pectoral, lateral thoracic, long thoracic, and thoracodorsal nerves for extrinsic musculature. The ventral branches that contributed the most to the plexus formation in the right antimer were C5 and C8, while in the left antimer, it was C7. The resulting nerves and the innervation for extrinsic and intrinsic musculature were similar to those observed in other rodents and representatives of the Mammalia class in general.
Analysis of underlying disease and infection source with sepsis patients: A 10-year prospective study
Authors: Feng Qiangsheng , Xiaoqin Ha , yuejuan Song
Published: February 2024

Sepsis with high mortality in critically ill patients, although there are many methods for early identification of sepsis such as qSOFA and NEWS, which patients with underlying diseases or infection sites were more prone to sepsis with very little research, our objective to explore another way to the successful preventing sepsis. We collected 2789 sepsis patients who were diagnosed by positive blood culture from 2013 to 2023 in our hospital. The Sepsis incidence rate was 485.07/100 000 in hospitalization, males/females 1.85, there were 3088 pathogenic were isolated belonging to 165 species, E. coli was the most frequent agent 31.70% overall, followed by Klebsiella pneumoniae and S. aureus accounting for 14.33% and 11.26% respectively. We found cancers were the frequent underlying disease with sepsis accounting for 15.63% overall, followed by hematologic malignancy, uremia, gallstones, and cholecystitis, type 2 diabetes accounting for 14.49%,6.10%,5.81%, and 4.48% respectively. We found urinary tract infections (UTIs) were the first infection source accounting for 17.0% overall, followed by suppurative cholecystitis and cholangitis, pulmonary infection, and catheter-associated bloodstream infections (CABSIs) accounted for 12.7%,11.9%, and 11.0% respectively. The sepsis mortality was 32.27%, ICU, hematologic malignanc, cancers, candidemia, mixed infection, pulmonary infection, and abdominal sepsis being the main mortality risk factors. Those studies reveal sepsis was common with cancers and hematologic malignancy patients, infection sources were mainly UTIs, suppurative cholecystitis and cholangitis, pulmonary infection, and CABSIs, the mortality risk factors for BSIs were ICU, hematologic malignancy, cancers, and candidemia.
Making Sense of Change after Intensive Trauma Treatment; a Mixed- Method Study into Adolescents Experience of Efficacy
Authors: Ee Elisa van , de Beijer Dani , Florisson Desirée , Geuskens Fenna
Published: February 2024

While evidence-based interventions are effective for children with post-traumatic stress disorder (PTSD), some adolescents may not respond sufficient. Intensive trauma treatment (ITT) has shown promise for adults, but research on its efficacy for adolescents is limited. This study adopts a mixed-method approach, combining clinical data and narratives, to explore the efficacy and subjective experience of change in 22 adolescents participating in ITT. Quantitative analysis revealed a significant reduction in PTSD symptoms post-ITT, aligning with prior research. Qualitative analysis highlighted themes such as negative thoughts impacting treatment success, the importance of social support, and identity-related struggles. The study contributes to understanding ITT efficacy and emphasizes the need for developmental sensitivity, systemic interventions, and continued research to enhance PTSD treatment for adolescents.
Effect of Rab8a on proliferation and migration of esophageal squamous cell carcinoma cells and its molecular mechanism
Authors: Liu Rong , Kang Zhanting , Gan Ting , Wang Yangruonan , Huangfu Zhiyuan , Cui Jing , Wang Yongxia
Published: February 2024

Purpose To explore the expression and function of Rab8a in esophageal squamous cell carcinoma (ESCC).
Methods The study first used TIMER, GEPIA and UALCAN to analyze the expression of Rab8a in a variety of clinically common malignancies including ESCC, followed by real-time PCR (quantitative real-time PCR, qPCR), Western blot, immunohistochemical (IHC) tests, and a series of in vitro biological experiments.
Results Rab8a is highly expressed in the esophageal cancer cells and tissues, and its expression is significantly correlated with the size and depth of invasion of the esophageal squamous carcinoma. overexpression of Rab8a can promote the proliferation and migration of ESCC while knockdown its expression can inhibit the proliferation and migration of ESCC, indicating a positive correlation of Rab8a with NDUFA1 and CYC 1 expression through GEO database analysis. Therefore, Rab8a may promote ESCC progression by activating mitochondrial respiration.
Conclusions
This study demonstrated that Rab8a is upregulated in ESCC and may promote its proliferation and migration by activating mitochondrial respiration. This study provides a rationale for clinical diagnosis and screening of new therapeutic targets for ESCC.
Efficacy and Safety of Conservative Treatment in Patients with Neurologically Intact Thoracolumbar Burst Fractures: A Meta-Analysis
Authors: Grin Andrey , Karanadze Vasiliy , Kordonskiy Anton , Talypov Aleksandr , Lvov Ivan
Published: February 2024

Objective: To conduct a systematic review and meta-analysis of studies focused on conservative treatment for thoracolumbar burst fractures (TLBF), and to determine efficacy and safety of this method in these patients.
Materials and Methods: The study was performed following PRISMA guidelines. Inclusion criteria were: 1) full-text articles in English and Russian; 2) A3 or A4 type fractures according AOSpine classification; 3) absence of neurological deficit; 4) patients aged over 18 years; 5) detailed description of treatment outcomes or complications; 6) a follow-up of at least one year.
Results: A total of 29 studies, including 1107 patients, were analyzed. Initial assessments showed a pooled mean for Cobb angle of 13.60 (95%CI, 10.8 – 16.5), vertebral body compression percentage of 39.9% (95%CI, 27.7 – 52.0), and spinal canal stenosis of 41.7% (95%CI, 29.2 – 54.2). Follow-up assessments indicated a significant increase in Cobb angle by 3.70 and vertebral body compression by 3.7%. The pooled prevalence for neurological deficit development and progression of TLBF instability were 5.8% (95%CI, 4.1 - 8.1) and 6.5% (95%CI, 4.5 - 9.3) respectively. Work status according to Denis scale was as follows: 1) W1 and W2, 74.7% (95%CI, 63.9 - 83.1); 2) W3, 14.1% (95%CI, 10.2 - 19.3); 3) W4 and W5, 14.8% (95%CI, 8.8 - 23.9).
Conclusion: Conservative therapy is an effective and safe option for patients with TLBF without neurological deficits and with initial kyphotic deformity up to 16°, vertebral body compression percentage up to 52%, and spinal canal stenosis up to 54.2%. The incidence of radiculopathy or myelopathy under conservative treatment is 5.8%. Orthopedic intervention may be required in 6.5% of patients. Over 90% of patients return to full-time work, either in their previous roles or under modified conditions. Future comparative studies between conservative and surgical treatments are needed to establish clear guidelines for managing patients with neurologically intact TLBF.
Synthesis, Characterization, and Evaluation of Antibacterial and Anticorrosion Properties of 4-Azo-3,5-sustituted-1,2,4-Triazole Polymers
Authors: Hamzah Bahaa Fadhil , Mhaibes Raed Muslim
Published: February 2024

In this study, a series of 4-azo derivatives of 1,2,4-triazole were synthesized through the reaction of melt thiocarbohydrazide with various substituted benzoic acids. Subsequently, these derivatives were coupled with different aromatic amines to obtain 4-azo derivatives of 1,2,4-triazole. The synthesized derivatives were then converted into 4-azo-3,5-substituted-1,2,4-triazole polymers using dry acetonitrile, pyridine, and poly acryloyl chloride. The physical properties, FT-IR spectra, and 1H-NMR spectra (for selected compounds) were utilized to confirm the structures of the synthesized compounds and polymers. Furthermore, the antibacterial and anticorrosion activities of the compounds and polymers were investigated.
COVID-19 Vaccine Uptake in Individuals with Functional Difficulty, Disability, and Comorbid Conditions: Insights from a National Survey in Bangladesh
Authors: Khanam Shimlin Jahan , Rana Md Shohel , Islam M Mofizul , Khan Md Nuruzzaman
Published: February 2024

Background: COVID-19 vaccine coverage among individuals with disabilities is crucial for safeguarding their health and well-being. However, the extent of vaccine coverage among this group remains largely unknown in low- and middle-income countries. This study aims to explore the COVID-19 vaccine coverage among persons with functional difficulty, disability and/or morbidity in Bangladesh.
Methods: Data from 9,370 respondents extracted from the 2021 National Household Survey on Persons with Disability were analysed. The outcome variable was the receipt of at least one dose of the COVID-19 vaccine (yes, no). Key explanatory variables included the presence of disability (yes, no), morbidity (yes, no), and both morbidity and disability (yes, no) among persons with functional difficulty. The relationship between the outcome and explanatory variables was determined using multilevel logistic regressions adjusted for covariates.
Results: The overall acceptance rate for at least one dose of the COVID-19 vaccine among persons with functional difficulty was 57.37%, among persons with functional difficulty and disability was 48.63% and among persons with functional difficulty and single (57.85%) or multi-morbidity (60.37%). Compared to the respondents with functional difficulty only, the adjusted odds ratio (aOR) of acceptance of at least one dose of the COVID-19 vaccine for individuals with both functional difficulty and disability was 0.73 (95% CI, 0.65-0.82) and 0.77 (95% CI, 0.70-0.87) for individuals with functional difficulty, disability and one or more comorbid conditions. The aOR for individuals with functional difficulty and one or more morbid conditions was significantly higher than that for persons with functional difficulty only.
Conclusion: In Bangladesh, COVID-19 vaccine coverage was relatively low among individuals with disabilities. The existing COVID-19 vaccine rollout programs and similar future programs should prioritise individuals with disabilities and include targeted strategies to reach them.
Diagnosing the role of atmospheric variability on the extreme summer monsoon precipitation events over India
Authors: kaagita Venkatramana , Thandlam Venugopal , Sakirevupalli Venkatramana Reddy , muriki Sathosh kumar , Mathew Milan , Byju Pookkandy
Published: February 2024

The study focused on the impact of atmospheric dynamics and thermodynamics on precipitation intensity during four extreme precipitation events (EPEs) in different locations across India from June to September 2019–2021. The magnitude and extent of precipitation observed in IMD and ERA5 varied during these EPEs. However, the occurrence of EPEs was strongly associated with enhanced convective potential energy, suppressed convective inhibition, low-level convergence, and high-level divergence, which favoured convection. EPEs were also linked to higher vorticity and a saturated atmosphere with relative humidity exceeding 80% in the upper layers. All EPEs experienced a strong low-level westerly flow and mid-tropospheric northerlies. While negative vertical velocity favouring uplift of warm moist air during EPEs, positive vertical velocities (subsidence) with reduced relative humidity below 60% were observed in the upper atmosphere after EPEs. A better understanding of EPEs can be achieved by including the enhanced view of thermodynamic components, such as the horizontal transport of water vapour and moist static energy, which have shown significant increases in magnitude during an EPE occurrence.
A Crank-Nicolson Finite Element treatment of time-dependent singularities of the one dimensional Heat equation
Authors: Nkeck Jake Leonard
Published: February 2024

The convergence rate of the Crank-Nicolson Finite Element Method (FEM) for the Heat equation can be affected if the solution entails time-dependent singularities. This paper presents a Crank-Nicolson FEM coupled to a Predictor-corrector algorithm to recover the optimal convergence rate when the solution has singularities. The FEM presented is based on the approximation of the time-dependent singular function by Fourier series. Numerical experiments are presented to show the efficiency of the method.
New approach method for solving nonlinear differential equations of blood flow with nanoparticle in presence of magnetic field
Authors: Hamzeh Morteza , Kachabi Amirreza , Sipey Milad Heydari , Ganji Davood Domiri
Published: February 2024

In this paper, effect of physical parameters in presence of magnetic field on heat transfer and flow of third grade non-Newtonian Nanofluid in a porous medium with annular cross sectional analytically has been investigated. The viscosity of Nanofluid categorized in 3 model include constant model and variable models with temperature that in variable category Reynolds Model and Vogel's Model has been used to determine the effect of viscosity in flow filed. analytically solution for velocity, temperature, and nanoparticle concentration are developed by Akbari-Ganji's Method (AGM) that has high proximity with numerical solution (Runge-Kutta 4th-order). Physical parameters that used for extract result for non dimensional variables of nonlinear equations are pressure gradient, Brownian motion parameter, thermophoresis parameter, magnetic field intensity and Grashof number. The results show that the increase in the pressure gradient and Thermophoresis parameter and decrease in the Brownian motion parameter cause the rise in the velocity profile. Also the increase in the Grashof number and decrease in MHD parameter cause the rise in the velocity profile. Furthermore, either increase in Thermophoresis or decrease in Brownian motion parameters results in enhancement in nanoparticle concentration. The highest value of velocity is observed when the Vogel's Model is used for viscosity.
Ionosound Data Analysis for Precise Study of Ionospheric Electron Density
Authors: Dinede Amsalu Hundesa
Published: February 2024

The ionosphere, crucial for communication, navigation, and space weather forecasting, pro foundly impacts our technological infrastructure by reflecting and refracting radio waves. Enter Ionosound, a cutting-edge ionospheric sounder system revolutionizing our ability to capture and analyze ionospheric data. Unlike traditional radar, Ionosound employs sound waves to probe electron density profiles, unlocking new insights into the ionosphere’s intricate dynamics. This paper delves into Ionosound’s principles, capabilities, and applications in studying electron density, showcasing its pivotal role in advancing atmospheric research and space weather prediction. With a focus on electron density profiles peaking between 150-350 km, we examine Ionosonde measurements capturing reflections from the E-layer to the F2 peak, with notable absorption observed in the D-layer below the E-layer. We leverage key ionospheric parameters such as electron density profile (Ne), maximum electron density (NmF2), maximum ionization height (hmF2), and critical frequency (foF2) to deepen our analysis. However, it’s important to acknowledge Ionosonde’s limitation in probing only the lower ionospheric region, prompting us to supplement our findings using the Chapman electron density profile to extend observations to upper layers. Through meticulous analysis, Ionosound empowers scientists to explore the ionosphere’s responses to diverse phenomena with unprecedented precision, shaping the future of atmospheric science and space exploration.
SİYASİ İDEOLOJİLERİN HÜRRİYETE KARŞI SUÇLARA ETKİSİ
Authors: Egemenoğlu Alaaddin
Published: February 2024

İlk zamanlardan itibaren özellikle insanların devlet çatısı altında örgütlenerek toplumu oluşturdukları bir ortamda, bireylerin hürriyetlerini ne ölçüde kullanabilecekleri siyasi iktidar tarafından belirlenmektedir. Hürriyet, uygulanan siyasi rejimle doğrudan ilişkili bir kavramdır. Tarihte anarşist, liberal, faşist ve Marksist gibi bazı siyasi ideolojiler ortaya çıkmış ve hürriyet anlayışını şekillendirmiştir. Devlet otoritesini asla kabul etmeyen ve bireylerin kendi aralarında sözleşme yaparak özgürlüklerinin çerçevesini belirleyebileceğini savunan anarşist düşüncenin ceza kanunları üzerinde hiçbir etkisi yoktur. Bireylerin hürriyetine yönelik ihlalleri cezalandıran ve bireyi esas alan ceza kanunları liberal hürriyet anlayışını ortaya koymaktadır. Liberal hürriyet anlayışı, hürriyete karşı işlenen suçlar bağlamında ceza kanunları üzerinde büyük bir etkiye sahiptir. Öte yandan bireyin hürriyetleri yerine siyasi iktidarın bekasını ve gücünü önceleyen ceza kanunları ise, faşist ve Marksist ideolojiyi benimsemektedir. Faşist ideolojide bireyler devletin çıkarları ve izni doğrultusunda belirli hürriyetlere sahip olabilirler. Marksist ideolojide ise, gerçek hürriyete ulaşmanın yolu devletin iktidarını sağlamak için demokratik hürriyetlerden vazgeçmektir. Bu ideolojiler, hürriyete karşı suçlar bağlamında ceza kanunlarını etkilemektedirler.
Stability of Complete and Star Multiplex Networks
Authors:   St. Petersburg State University, Ziyu Ma , Parilina Elena ,   St. Petersburg State University
Published: February 2024

We propose a concept of stability for multiplex networks. First, a utility function combining benefits and costs from network connections is introduced. The utilities significantly influence incentives of players in link formation and, consequently, network structure. Costs are derived from direct links connecting players. We examine the stability conditions of multiplex networks with special network structures, in particular, complete and star network in all layers, and compare the stability conditions for two different type of benefits (with and without decay).
A Sustainability Measurement Framework of Supply Chain Information Flow: The Case of Industry 4.0 Technology Implementation
Authors:   St. Petersburg State University, Todorova Anna , Zyatchin Andrey ,   St. Petersburg State University
Published: February 2024

In the presented paper a methodology for evaluation the sustainability of supply chain information flow that allows to find the most sustainable Industry 4.0 technology for implementation in oil & gas industry is developed: it is constructed the tree of key criteria for measuring sustainability of supply chain information flow, the evaluation framework for quantitative measuring sustainability of supply chain information flow is proposed, the recommendations of Industry 4.0 technology implementation are formulated.
Cooperative Stock Market Game
Authors:   St. Petersburg State University, Jianpeng Zhang , Tian Lu ,   Yan’an University
Published: February 2024

This study explores the game-theoretic model of the stock market, analyzing the behavior and strategic choices of market participants, and constructing a cooperative game model. The basic concepts of game theory are introduced, and the importance and practical application of game theory in the stock market are explained. A cooperative game-theoretic model is constructed, the characteristic function is established, and its superadditivity is proven. The model is analyzed, the Shapley value is derived. It is demonstrated that the Shapley value belongs to the core.
Cooperative Solutions for Network Games with Quadratic Utilities
Authors:   Yan’an University, Chen Yan
Published: February 2024

This paper analyzes the public goods model with linear quadratic utilities in which each player determines the intensity of the activity they take, which can also be described as a network game with local payoff complementarity, as well as positive payoffs and negative quadratic costs. Players play cooperative games with each other, and cooperative solutions when the game is the planner’s optimal concern for the collective, describing each player’s optimal action in maximizing the individual and public interest. They are implemented programmatically to facilitate simple computations. In these games, players’ activities can be linked to their positions in the local interaction network. The cooperative actions taken by any player are proportional to their Katz-Bonacich centrality in a complementary linear quadratic game. In other words, higher Katz-Bonacich centrality, higher action. We then use a comparative statics framework to analyse the effect that changes in individual variables have on cooperative actions.
Multi-gauge calibration comparison for simulating streamflow across the Major River Basins in Madagascar: SWAT + Toolbox, R-SWAT, and SWAT + Editor Hard calibration
Authors: Harifidy Rakotoarimanana Zy , Hiroshi Ishidaira , Kazuyoshi Souma , Jun Magome , Harivelo Rakotoarimanana Zy Misa , Fernández-Palomino Carlos Antonio
Published: February 2024

This paper aims to improve the Soil and Water Assessment Tool (SWAT) model performance across the Major River Basins in Madagascar (MRBM), specifically for SWAT simulation in the Manambolo, Onilahy, Mananara, and Mandrare basins. A multi-gauge calibration was carried out to compare the performance of SWAT+ Toolbox, and R-SWAT, SWAT+ Editor Hard calibration on a monthly time step for the periods 1982–1999. We found that the SWAT+ model generated greater surface runoff, while the SWAT model resulted in higher groundwater flow in both CSFR and CHIRPS datasets. It has been demonstrated that the SWAT+ Toolbox had more potential in calibrating runoff across the MRBM compared to R-SWAT. Calibration in both methods led to a reduction in surface runoff, percolation, water yield, and curve number but increased the lateral flow, evapotranspiration (ET), and groundwater flow. The results showed that the multi-gauge calibrations did not significantly enhance simulation performance in the MRBM compared to single-site calibration. The performance of the SWAT+ model for runoff simulation within the SWAT+ Toolbox and R-SWAT was unsatisfactory for most basins (NSE < 0) except for Betsiboka, Mahavavy, Tsiribihina, Mangoro, and Mangoky basins (NSE = 0.40–0.70; R2 = 0.45–0.80, PBIAS≤ ±25), whether considering the CHIRPS or CSFR datasets. Further study is still required to address this issue.
The Emergence of N. sativa L. as a Green Antifungal Agent
Authors: Pandey Raghvendra , Pandey Brijesh , Bhargava Atul
Published: February 2024

Background:

Nigella sativa L. has been widely used in the Unani, Ayurveda, Chinese,
and Arabic medicine systems and has a long history of medicinal and folk uses. Several phytoconstituents
of the plant are reported to have excellent therapeutic properties. In-vitro and in-vivo studies
have revealed that seed oil and thymoquinone have excellent inhibitory efficacy on a wide range
of both pathogenic and non-pathogenic fungi.

Objective:

The present review aims to undertake a comprehensive and systematic evaluation of the
antifungal effects of different phytochemical constituents of black cumin.

Method:

An exhaustive database retrieval was conducted on PubMed, Scopus, ISI Web of Science,
SciFinder, Google Scholar, and CABI to collect scientific information about the antifungal activity
of N. sativa L. with 1990 to 2023 as a reference range using ‘Nigella sativa,’ ‘Nigella oil,’ ‘antifungal
uses,’ ‘dermatophytic fungi,’ ‘candidiasis,’ ‘anti-aflatoxin,’ ‘anti-biofilm’ and ‘biological activity’
as the keywords.

Results:

Black cumin seeds, as well as the extract of aerial parts, were found to exhibit strong antifungal
activity against a wide range of fungi. Among the active compounds, thymoquinone exhibited
the most potent antifungal effect. Several recent studies proved that black cumin inhibits biofilm
formation and growth.

Conclusion:

The review provides an in-depth analysis of the antifungal activity of black cumin.
This work emphasizes the need to expand studies on this plant to exploit its antifungal properties for
biomedical applications.