bluuebunny/crossref_metadata_2025 huggingface dataset:
The Role of Monitoring Platelet Function Perioperatively and Platelet Transfusion for Operated Spontaneous Intracerebral Hemorrhage Patients With Long-term Oral Antiplatelet Therapy: A Case Report
Authors: Wang Kaiwen , Li Maogui , Liu Qingyuan , Wu Jun , Cao Yong , Wang Shuo
Published: August 2020

Spontaneous intracerebral hemorrhage (SICH) with long term oral antiplatelet therapy (LOAPT) is known as a dilemma in balancing the risk of postoperative rebleeding and ischemic events because of confused coagulation function. In this case, the authors reported a 42 year old male SICH patient on LOAPT who received an emergency craniectomy. The thromboelastography suggested that the inhibition of platelet function was high preoperatively. After platelet transfusion during surgery and taking control of the clotting and platelet function postoperatively, the patient was stable without rebleeding and new ischemic events in perioperative period and recovered satisfactorily. The authors presented the importance of monitoring coagulation and platelet function perioperatively for SICH patients on LOAPT. Postoperatively, monitoring and taking control of clotting and platelet function would help in preventing rebleeding and ischemic events in SICH patients on LOAPT; moreover, platelet transfusion may quickly and safely reverse platelet dysfunction for emergency surgery.
Bronchial Thermoplasty Reduces Ventilation Heterogeneity Measured by Multiple Breath Nitrogen Washout
Authors: Langton David , Bennetts Kim , Thien Francis , Plummer Virginia , Noble Peter B
Published: August 2020

Background Despite demonstrated symptomatic benefit from bronchial thermoplasty (BT), the underlying pathophysiological benefits have been uncertain. The purpose of the present study was to relate clinical benefit after BT to changes in lung physiology, focusing on ventilation homogeneity assessed using multiple breath nitrogen washout (MBNW), and how this may be affected by changes in airway volume and resistance.MethodsConsecutive patients (n=21) with severe asthma scheduled for BT, were evaluated at baseline, 6 weeks and 6 months after completion of treatment. Assessments included the Asthma Control Questionnaire (ACQ), medication usage, exacerbation frequency, spirometry, plethysmography and MBNW. Eighteen of these patients underwent detailed CT evaluation for the estimation of airway volume at baseline and then after the left lung had received BT treatment but prior to right lung treatment. Data are mean±STDEV.ResultsPatients responded to BT with an improvement in ACQ from 3.4±0.8 at baseline to 2.0±1.1 at 6 months (p<0.001). Steroid requiring exacerbations fell from 3.1±2.9 in the 6 months prior to BT to 1.4±1.7 following BT (p<0.001). Significant reductions in maintenance oral steroid dosing and short acting beta agonist use were observed.Airway volume measured by CT scanning significantly increased after treatment. The FEV1 improved from 1.34±0.65 l to 1.52±0.76 l (p=0.024). The Residual Volume fell from 2.87±0.89 l to 2.71±0.93 l (p=0.008) and Total Airway Resistance (Raw) from 10.58±6.56 to 7.64±3.74 cmH2O.s.l-1 (p=0.020). The Lung Clearance Index (LCI) was 187±63% predicted at baseline and improved after treatment from 12.7±3.3 to 11.8±2.4 (p=0.049). The improvement in LCI correlated with the improvement in Raw (r=0.463, p=0.035). Conclusion Clinical benefit after BT is accompanied by improvements in lung physiology, including normalisation of lung homogeneity that seems to be driven by airway dilation and reduced resistance.
Examination Of The Relationship Between Oil Price Shock And Macroeconomic Variables In Nigeria
Authors: Awujola Abayomi , Iyakwar Anna Dyaji Baba , Bot Ropheka Emerson
Published: August 2020

The price of oil is one of the important macroeconomic indicators because of the extreme importance of supplying oil to different countries of the world to meet their energy needs. As Nigeria’s economy depends on oil prices, the country remains vulnerable to fluctuations in world oil prices. During periods of rising oil prices caused by macroeconomic and political conditions in the international market, the state usually has a positive trade balance, there is an increase in foreign exchange reserves and the revaluation of the national currency. The purpose of the article is to evaluate the relationship between an oil price change and Nigeria’s economic growth rate using regression analysis. The source of statistical information is data from the National Bureau of Statistics, the Nigerian National Petroleum Corporation, and the Nigerian Energy Commission. By checking the time series for steady-state using the advanced Dickie-Fuller test, a regression equation is constructed where the dependent variable is represented as the price of oil and the independent variables are key macroeconomic indicators. The econometric model constructed is adequate because the determination coefficient and the adjusted determination coefficient are 0.97 and 0.96 respectively. The Durbin-Watson statistic in the model is 1.98, meaning the model is reliable. Oil price fluctuations have been found to be related to investment, economic growth, and exchange rates, as well as to inflation. The paper argues that the use of the shock of oil prices should be supported, as it promotes economic growth and is not inflationary. Therefore, the authors believe that the government, which is the main beneficiary of cash, should also implement strategies that counterbalance the propensity for the economic downturn. Based on the analysis, a set of priority measures was proposed: enhancing financial liberalization, combating corruption, transparency of government activities, creating an open currency market, and developing non-inflationary monetary and fiscal strategies.

Keywords: oil price, macroeconomic variables, energy needs, Organization of Petroleum Exporting Countries, Dickie-Fuller Extended Test, Petroleum Exporters.
THE USE OF CORRECTIVE TECHNOLOGIES IN THE PROCESS OF PREPARING SENIOR PRESCHOOLERS WITH AUTISM SPECTRUM DISORDER FOR LEARNING ACTIVITIES
Authors: Sidenko Yuliia , Kolyshkin Oleksandr
Published: August 2020

The authors of the article have analyzed scientific research on the problem of the formation of cognitive readiness for educational activity in children with autism spectrum disorders of senior preschool age. It is noted that for children with autism spectrum disorders, a special approach should be applied with a focus on world standards and effective methods of correction and training should be developed. It is revealed that today the psychological and pedagogical correction of the development of autism does not have unambiguity and consistency regarding technologies and methods that would help to effectively overcome autism spectrum disorders and contribute to the effective preparation of autistic children for educational activities. The content of the concept of "cognitive readiness" is revealed as a prerequisite for the development of psychological characteristics and preparation of a child with autism spectrum disorders of senior preschool age for learning activities. The features of the use of correctional technologies to increase the level of cognitive readiness for educational activity of children with autism spectrum disorders of senior preschool age have been determined. It was revealed that the main condition for the formation of cognitive readiness for educational activity in children with autism spectrum disorders of senior preschool age is the use of ABA therapy technology, the TEACCH program, (PRT), PECS, sensory integration. It is revealed that the program (TEACCH, PECS) reflects a clear algorithm of actions, encourages mental operations; method (ABA-therapy) improves the stability of concentration, memory development, forms learning behavior; (PRT) promotes the development of motivation in a child with autism spectrum disorder of senior preschool age, self-management. The formation of imagination and perception of the surrounding world is carried out in the process of conducting classes with sensory integration. It is proved that the formation of cognitive readiness for educational activity in senior preschoolers with autism spectrum disorders is an important factor in the realization of personal potential and social adaptation.
MECHANISMS OF AUTONOMIC DYSFUNCTION REALIZATION DURING COMORBID GASTROESOPHAGEAL REFLUX DISEASE AND NEUROCIRCULATORY DYSTONIA WITH INSOMNIA AMONG YOUNG PEOPLE
Authors: Oparin Aleksey , Oparin Anatoliy , Balaklytska Iryna , Khomenko Ludmila
Published: August 2020

The aim of the study: to optimize diagnostics and treatment of comorbid gastroesophageal reflux disease (GERD) and concomitant neurocirculatory dystonia (NCD) with insomnia among young people by studying autonomic dysfunction and mechanisms of its realization.

Methods. The study was conducted in three groups of patients, homogeneous by gender and age. The first group included patients with GERD and insomnia, the second group counted those with NCD and insomnia, and the third group consisted of GERD with NCD and insomnia. We studied the quality of life (SF-36), quality of sleep (PSQI), the presence and severity of depression (PHQ-9), psychosomatic condition (Spielberger-Khanin scale), and determined the presence and severity of autonomic dysfunction syndrome (Wayne questionnaire), acidity of the stomach, ultrasound examination of the esophagus and stomach.

Results. The first group revealed sympathicotonia and increase of gastric juice aggression (in the stomach body 0.89±0.05) and reactive (47.2 points) and personal anxiety (52.7 points), which suggests the advisability of use PPI (omeprazole 20 mg 2 times a day for 5 weeks), and melatonin 3 mg per night during 3 weeks. The second group showed parasympathicotonia predominant, a more pronounced decrease in vitality scale (31.5±4.2), and a moderate increase in indicators of reactive (44.0 points) and personal anxiety (46.5 points), which suggests the advisability of use 3 mg of melatonin per night during 3 weeks. The third group demonstrated predominance of parasympathicotonia, motor disorders, a decrease in alkalizing function of antrum (5.4±0.17), depression (81.8 %), and the greatest decrease in indicators of sleep quality (11.7) and quality of life, which suggests the advisability of use PPI (omeprazole 20 mg 2 times per day during 5 weeks), with prokinetics (domperidone 10 mg 3 times per day during 5 weeks), and melatonin 3 mg per night during 3 weeks.

Conclusions. Autonomic dysfunction has a key influence on the main pathogenetic factors in the formation of both GERD and NCD and insomnia, and the type of autonomic tone determines the features of the clinical course of both isolated and combined pathology.
THE IMPORTANCE OF NON-INVASIVE REGIONAL BRAIN OXIMETRY IN PREVENTING POSTOPERATIVE COGNITIVE DYSFUNCTION DURING LAPAROSCOPIC CHOLECYSTECTOMY IN ELDERLY AND SENILE PATIENTS
Authors: Bielykh Olena
Published: August 2020

The adverse effect of general anesthesia in elderly patients during surgery requires monitoring of functions and processes to identify their dangerous abnormalities to prevent complications.

The aim of the study. To establish the effectiveness of non-invasive regional brain oximetry with rSO2 determination during anesthetic support in laparoscopic cholecystectomy (LCE) to prevent postoperative cognitive dysfunction in elderly and senile patients.

Material and methods. 84 elderly and senile patients with diagnosed gallstone disease, acute cholecystitis, who underwent LCE with sevofluran inhalational anesthesia and total intravenous anesthesia with propofol were examined. rSO2 was monitored. Cognitive functions were assessed using neuropsychological scales and the MMSE mental state examination scale.

Results. rSO2 was found to be significantly decreased during the carbon dioxide insufflation as compared to before premedication: in LH (left hemisphere) – by 7.0 %, in RH (right hemisphere) – by 6.9 % (Group I); in LH – by 7.4 %, in RH – by 7.5 % (Group II). rSO2 was significantly increased during the surgery, particularly in the middle of the operation, as compared to before premedication: in LH – by 14.66 %, in RH – by 13.94 % (Group I); in LH – by 11.60 %, in RH – by 11.53 % (Group II). The day following the surgery, cognitive functions significantly decreased by 8.7 % on the Luria's test, by 6.0 % on the MMSE test (Group I); in Group II – by 10.1 % and 6.3 %, respectively, as compared to before premedication. On Day 5 after the surgery, cognitive functions decreased by 2.7 % on the Luria's test, by 0.35 % on the MMSE test (Group I); in Group II – by 2.7 % and 0.35 %, respectively, as compared to before premedication.

Conclusions. A decrease in rSO2 can occur during LCE in the Trendelenburg position, despite the fact that other intraoperative indicators remain stable, which allows it to remain unrecognized. rSO2 monitoring in the perioperative period contributes to alertness and timely measures to prevent postoperative cognitive dysfunction.
Biologically active peptides of meat and meat product proteins: a review. Part 2. Functionality of meat bioactive peptides
Authors: Chernukha I. M. , Mashentseva N. G. , Afanasev D. A. , Vostrikova N. L.
Published: August 2020

Biologically active peptides (BAP) are regarded as the main products of protein hydrolysis. BAP activity depends on the amino acid sequence molecular weight and chain length, type and charge of an amino acid at the N-terminus and C-terminus, hydrophobic and hydrophilic properties, spatial structure. They positively influence many systems of the human body, including the blood circulatory, nervous, immune, gastrointestinal and other systems. The health-improving effect of bioactive peptides is formed due to their antioxidant, antihypertensive, antithrombotic, immunomodulatory, antimicrobial, anti-allergic, opioid, anti-inflammatory, hypocholesterolemic and anticancer properties. Angiotensin-I-converting enzyme (ACE) inhibitory peptides are most studied due to their effect on blood pressure regulation. Unlike synthetic preparations, biologically active peptides do not have side effects and, therefore, can be used as their alternative. There is a growing commercial interest in peptides generated from meat proteins is in the context of health saving functional foods. The paper describes prospects, pros and cons of using bioactive peptides as functional food ingredients and biologically active food additives.
Biochemical and histological indicators of blood and m. longissimus dorsi of young bulls of Kazakh white-headed breed of different genotypes by the CAPN1 and GH genes
Authors: Selionova M. I. , Plakhtyukova V. R.
Published: August 2020

The use of molecular genetic markers for productivity is one of the modern approaches in breeding beef cattle. The article presents the results of the studies on the influence of genotypes by the calpain (CAPN1) and growth hormone (GH) genes on live weight, fatty acid composition of blood plasma, quantitative and qualitative indicators of meat of young cattle of Kazakh white-headed breed. It was established that animals of the homozygous geno-types СС–CAPN1 and VV-GH had a larger live weight and its average daily gain on the 240th and 365th days. Their superiority over the GG and LL genotypes was 13.8% (P<0.05) and 6.9%; 14.6% (P<0.05) and 6.9%, respectively. The carriers of the desirable alleles in the homozygous state had the sum of unsaturated fatty acids higher by 6.3% and 7.1%, respectively, than the young bulls, in which genotypes they were absent. The predominance of unsaturated fatty acids over saturated fatty acids also determined lower values of lipid me-tabolism direction index (0.92 and 1.00) in the animals with the desirable genotype. Muscle tissue of animals of the СС and VV genotypes was characterized by a higher level of protein, fat by 0.28–2.13 abs. per cent, energy value, and the quantity of muscle fibers with a smaller diameter per unit area compared to the GG and LL genotypes by on average 8.7% and 25.5% (P<0.01). Due to the greater number of interfiber fat inclusions, muscle tissue of the desirable genotypes received higher marbling scores. The obtained data testify to the prospects of replication of animals, which genotype has the desirable alleles for further improvement of traits of meat productivity of Kazakh white-headed breed.
Fintech in the eyes of Millennials and Generation Z (the financial behavior and Fintech perception)
Authors: A. M. Abu Daqar Mohannad , Arqawi Samer , Abu Karsh Sharif
Published: August 2020

This study investigates the Millennials and Gen Z perception toward Fintech services, their usage intention, and their financial behavior. The study took place in the Palestinian context with a global comparison among these generations. The authors used the questionnaire-based technique to meet the study objective. West Bank respondents were selected for this purpose; the study instrument was distributed through different social media channels. The findings show that reliability/trust and ease of use are the main issues in using a financial service. Millennials are more aware (48%) of Fintech services than Gen Z (38%), which is different from the global view where Gen Z is the highest. The smartphone penetration rate is 100% among both generations, while the financial inclusion ratio in Palestine is around 36.4%; these clear indicators are the main Fintech drivers to promote Fintech services in Palestine, and these are global indicators for Fintech adoption intention. Both generations (84%) intend to use e-wallet services, Millennials (87%) and Gen Z is (70%) prefer using real-time services. Half of the respondents see that Fintech plays a complementary role with banks. The majority see that Fintech services are cheaper than bank services. Wealth management, and robot advisor services, and both generations are looking to acquire them in the long run. The authors revealed that 85% of respondents from both generations trust banks, so it is recommended that banks digitize their financial services to meet the customers’ needs, considering that 90% of respondents see that promotions are a key issue in adopting Fintech services. Promoting e-wallet services by banks is highly recommended due to the massive rivalry with Fintech parties.
Prenatal diagnostics in carrier of pericentric inversion of
the chromosome 6
Authors: E.I. Golovataya , T.A. Plevako , D.A. Mykytenko
Published: August 2020

Two cases with different recombinant chromosomes associated with a paternal pericentric inversion inv(6)
(p25q25.3) are presented. The data of ultrasound and cytogenetic studies, as well as the results of preimplantation
genetic testing of embryos obtained in in vitro fertilization cycles are presented. Based on our own and published
data, the possibility of the appearance of recombinant chromosomes in the progeny of inv(6)(p25q25.3) carrier
is discussed.
Prenatal diagnosis of unilateral cerebellar hypoplasia
Authors: O.I. Guseva
Published: August 2020

A case of prenatal diagnosis of hypoplasia of the left hemisphere of the cerebellum in a fetus at 32 weeks
of gestation is presented. Concomitant developmental abnormalities were not detected. The development of
a child at 13 months of life corresponds to the age norm.
A case of prenatal diagnosis of corpus callosum lipoma
Authors: A.I. Zamiatina, M.V. Medvedev
Published: August 2020

A case of prenatal diagnosis of the corpus callosum lipoma at 32–33 weeks of gestation is presented.
In a consultative examination, a hyperechoic formation with clear contours was found in the projection of the
septum pellucidum, occupying the rostrum, genu, and truncus of corpus callosum, without signs of intratumorally
blood flow in the color Doppler mapping mode. The prenatal diagnosis of "callosum lipoma" was established,
confirmed after the birth of a child during magnetic resonance imaging.
Prenatal diagnosis of Di George syndrome of the fetus with tetralogy
of Fallot
Authors: O.A. Grammatikova, , G.A. Ryabchenko , A.M. Bondarev
Published: August 2020

Prenatal diagnosis of deletion 22q11.2 of the fetus in the second trimester of pregnancy, suspected on
the basis of congenital heart disease (tetralogy of Fallot) in the combination with thymus hypoplasia, is presented.
The pregnancy was interrupted.
Ethical conflicts around the procedure preimplantation genetic diagnosis
and their overcoming by legal remedies based on foreign experience
Authors: N.A. Altinnik , V.V. Komarova , M.A. Borodina et all
Published: August 2020

Objectives. The purpose of this study is to study the essence of ethical conflicts arising over the use of
preimplantation genetic diagnosis (PGD) and to identify ways to overcome them by legal means, taking into
account existing foreign experience.
Materials. The legal acts and doctrinal sources of Australia, Great Britain, Canada, China, New Zealand,
USA are investigated. The methods used are: general philosophical, general scientific, private scientific, special
(structural-legal, comparative-legal, formal-legal).
Results. Ways to resolve ethical conflicts around the PGD procedure that are relevant for use in Russian
conditions are proposed.
Conclusions. It was established that the resolution of ethical conflicts around the procedure should be
based on state legal regulation of requirements related to informing patients about the content of the services
provided and the consequences of the procedure, methods and procedures for the independent interpretation of
the results. In addition to the official fixing of the list of genetic diseases, for the presence of markers which are
allowed to conduct research, the legislation on the protection of the health of citizens must establish a procedure
for authorizing PGD in exceptional cases, as well as factors and circumstances that must be taken into account
and evaluated when an appropriate decision is made (including the features of a family history, an assessment
of the degree of impaired function of the organism, the state of individual organs and their systems during
development of the corresponding disease, etc.). Regulatory requirements can be supplemented and developed
in the content of professional manuals
Treatment of zinc plating wastewater by combination of electrocoagulation and ultrafiltration process
Authors: Öztel Merve Dönmez , Kuleyin Ayşe , Akbal Feryal
Published: August 2020

In this study treatment of zinc plating wastewater by combination of electrocoagulation (EC) and ultrafiltration (UF) processes was investigated. The effect of operating parameters such as wastewater pH, flow rate and membrane pore size on zinc removal was investigated to optimize the EC-UF process. The results showed that zinc removal was pH dependent and optimum pH was 9.0. The zinc removal over 99% was achieved by the combined EC-UF process with both 50 and 100 kDa membranes at pH 9.0 and current density of 5 mA cm−2. Suspended solids and oil–grease were also removed completely by the combined EC-UF process. The EC-UF process proved to be a promising technology for the treatment and recycling of zinc plating wastewater.
Dalton Trevisan, João Antônio e Rubem Fonseca
Authors: Junior Valdemar Valente
Published: August 2020

Este artigo tem por objetivo identificar elementos da violência e da escatologia nos contos de Dalton Trevisan, João Antônio e Rubem Fonseca como termos específicos que decorrem do processo de industrialização do pós-guerra e da sequente implantação da ditadura militar no país. Nesse sentido, o descontrole que se verifica em razão do crescimento urbano contribui para que as várias manifestações da contravenção e da criminalidade se ampliem em dimensão inimaginável. Isso habilita os contos escolhidos para efeito deste artigo a funcionarem como representações que identificam um universo da desordem, do sadismo e violência. Assim, A velha querida, de Dalton Trevisan, Leão-de-chácara, de João Antônio, e Feliz Ano Novo, de Rubem Fonseca, podem funcionar como recortes da escatologia que busca afrontar o sistema político e identificar seus descaminhos como única ferramenta à disposição desses escritores.
“Outrora Esquecidos”
Authors: Dal Piva Jéssica
Published: August 2020

Neste estudo, apresento alguns aspectos simbólicos evidenciados a partir das reformas realizadas no Cemitério Municipal Cristo Rei, localizado na Avenida Maripá, no Município de Toledo/PR, na primeira década do século XXI. Na reforma, houve um trabalho simbólico e novos elementos foram inseridos no espaço, ao mesmo tempo em que alguns elementos antigos foram mantidos e valorizados. Assim, escolhi um dos monumentos que compõem o espaço cemiterial remodelado: a Quadra 27, que é composta por enterramentos realizados entre os anos de 1953 até 1972. Durante a reforma da necrópole, “os esquecidos” foram homenageados através da identificação de seus nomes e da colocação de placas no corredor principal do cemitério. O elemento em análise são os “Arcos da Vida” – onde estão as placas com os nomes “dos esquecidos”.
Cidade política, cidade poética:
Authors: Carvalho da Silva Jeferson
Published: August 2020

Este artigo tem como objetivo esboçar a ampliação das categorias “inscrição” e “circulação” abordadas pela antropóloga Teresa Caldeira. Tais categorias referem-se a práticas de ocupação e produção dos espaços públicos das cidades. As imagens, nesse processo, auxiliadas pela busca de caminhos de aplicação e construção de “olhares disciplinados para ver as cidades”, propostos por Urpi Montoya Uriarte, se tornaram elementos importantes para observar e interpretar a realidade de ruas, becos e avenidas da cidade de Viçosa (MG), onde se deu o campo dessa pesquisa. Sob essas perspectivas nos aproximamos de uma cidade em constante movimento, produzida e ressignificada cotidianamente por seus habitantes.
O SISTEMA DE SEGURANÇA ALIMENTAR E NUTRICIONAL COMO MECANISMO DE GOVERNANÇA NO ÂMBITO MUNICIPAL NO RIO GRANDE DO NORTE, BRASIL
Authors: Medeiros Laís Crislaine Duarte de , Calazans Dinara Leslye Macedo e Silva , Pequeno Nila Patrícia Freire , Bagni Ursula Viana , Câmara Jean Pierre Tertuliano , Silva Amanda Patrícia Gomes da
Published: August 2020

Introdução: O SISAN – Sistema de Segurança Alimentar e Nutricional representa a institucionalização de governança para atuar na Segurança Alimentar e Nutricional (SAN) de forma articulada e intersetorial no Brasil. Objetivo: Este estudo objetiva compreender os desafios enfrentados pela gestão pública nos níveis municipais para implementação do SISAN no Rio Grande do Norte em relação às práticas de governança. Métodos: O estudo consiste em uma pesquisa-ação, no qual foi realizado um recorte das ações do projeto SISAN Universidades no RN. Este é um projeto de extensão envolvendo três universidades federais (UFPB, UFRPE, UFRN) desenvolvido para fortalecer e/ou implantar os componentes municipais do SISAN, a saber: o COMSEA (Conselho Municipal de Segurança Alimentar e Nutricional) e a CAISAN (Câmara Intersetorial de Segurança Alimentar e Nutricional) nesses estados (PB, PE e RN). Foram coletados dados de questionários estruturados aplicados aos gestores (n=68), documentos do projeto que incluíam atas, relatórios, fichas de avaliação e demais materiais. Incluídas observações realizadas durante as assessorias da equipe de articuladores aos municípios (n=45), nos encontros territoriais (n=10), oficinas regionais (n=03) e reuniões com lideranças sociais (associações, sindicatos, ONGs, Grupos populares, Povos e Comunidades Tradicionais, entre outros), profissionais e demais gestores públicos, resultando em um total de 651 pessoas consultadas. Resultados: Foi observada alta rotatividade e falta de qualificação de técnicos e gestores, logo, a perda de referências e informações relevantes sobre o SISAN; o desconhecimento sobre os recursos para ações e mobilizações em prol da operacionalização dos planos e ausência da mobilização dos demais atores para adesão do SISAN. Conclusões: Conclui-se, que o baixo número de municípios aderidos ao SISAN, as dificuldades durante os processos de formação de COMSEAs e CAISANs e a necessidade do fortalecimento das instâncias já estabelecidas visam um compromisso firme do governo junto à sociedade civil organizada para dar prosseguimento as ações de SAN.
CORRELAÇÃO ENTRE OS ÍNDICES ANTROPOMÉTRICOS E PRESSÃO ARTERIAL DE ADOLESCENTES E ADULTOS JOVENS EM UM MUNICÍPIO DO NORDESTE BRASILEIRO
Authors: Cassiano Maria Helena , Santana Luz Anna Beatriz , Bezerra Mariana Silva , Barbosa Suamy Sales , Silva Hémyllen Taísa Diniz da , Araújo Daline Fernandes de Souza
Published: August 2020

Introdução: A Hipertensão Arterial Sistêmica tem apresentado alta mortalidade em todo o mundo, associada a fatores de risco cardiovascular como o excesso de peso e a obesidade abdominal. Objetivo: Avaliar os índices antropométricos e pressão arterial em adolescentes e adultos jovens do município de Santa Cruz-RN. Método: Trata-se de um estudo quantitativo, do tipo transversal, realizado com 86 indivíduos com idade média de 19,0 ± 0,97 anos. Foram avaliados o Índice de Massa Corporal (IMC), Relação Cintura Estatura (RCE), Relação Cintura Quadril (RCQ), Índice de Conicidade (IC) e Pressão Arterial (PA). Os dados foram analisados no programa SPSS versão 23.0, apresentados em percentual, média e desvio padrão. O teste T de Student foi aplicado para avaliar a diferença entre as médias, a correlação entre medidas antropométricas e a pressão arterial pela correlação de Pearson. Resultados: A prevalência maior foi do sexo feminino, 81,4%. A obesidade esteve mais presente nos meninos adolescentes do que nas meninas, 33,3 e 13,9% respectivamente, bem como nos adultos jovens 28,6% em homens e 11,8% em mulheres. A RCE se mostrou mais elevada nas meninas e mulheres adultas (0,46 ± 0,07, 0,50 ± 0,08). Em contrapartida, a RCQ e IC se mostraram maiores nos meninos (0,79 ± 0,06; 1,12 ± 0,74)  e nos homens adultos (0,82 ± 0,09; 1,15 ± 0,12) respectivamente. Em ambos os grupos houve correlação positiva moderada entre o IMC e a RCE com a PA (p<0,05). Conclusões: Os índices antropométricos apresentaram correlação positiva com a elevação da pressão arterial, destacando-se o IMC e a RCE nos adolescentes e adultos jovens.

Palavras-Chave: Antropometria, Estado Nutricional, Hipertensão Arterial.
VARIABILIDADE ESPACIAL DA UMIDADE E CONDUTIVIDADE ELÉTRICA DO SOLO EM VALE ALUVIAL UTILIZANDO TÉCNICAS GEOFÍSICAS
Authors: Lins Frederico Abraão Costa , Lopes Iug , Montenegro Abelardo Antônio de Assunção
Published: August 2020

Os métodos de indução eletromagnética na agricultura de precisão possuem alto potencial em aplicações voltadas para estudos da variabilidade espacial da salinidade e umidade do solo. O objetivo deste trabalho foi verificar o desempenho do EM38® em vale aluvial no semiárido para fins de aplicação de agricultura de precisão, e avaliar a dinâmica e dependência espacial da umidade e da condutividade elétrica em diferentes profundidades do solo. A área de estudo está localizada no município de Parnamirim, Pernambuco, no Campus Avançado de Agricultura Irrigada de Parnamirim da Universidade Federal Rural de Pernambuco. Duas malhas regulares foram adotadas, uma de 10 x 10 m para amostragem de condutividade elétrica aparente do solo (CEa) estimada com o aparelho EM38® e outra de 20 x 10 m para amostragem de solo, para determinação da umidade, salinidade, silte e argila nas camadas de 0-0,3 m, 0,3-0,6 m e 0,6-0,9 m. Informações diretas e indiretas foram utilizadas nas análises geoestatísticas, construção de semivariogramas e krigagem de mapas. O Grau de Dependência Espacial dos atributos avaliados variou entre forte e moderado. Maior umidade na camada mais profunda do solo foi constatada, as maiores CEa foram encontradas na camada 0,3-0,6 m. O EM38® mostrou-se eficiente na estimativa da condutividade elétrica do solo, e possibilitou a validação de modelo de regressão previamente calibrado na mesma área, em período com restrição hídrica no solo.
FATORES GEOMORFOLÓGICOS NA CONTRIBUIÇÃO DE OCORRÊNCIA DE PROCESSOS EROSIVOS AS MARGENS DA RODOVIA TO-445, MUNICÍPIO DE MIRACEMA-TO
Authors: Medeiros Glacielle Fernandes , Castro Athos Sousa , Rodrigues Rafael Junior Resplandes , Resplandes Jhonathan Morais , Almeida João Guilherme Rassi
Published: August 2020

Processos erosivos são fenômenos nos quais materiais inconsolidados da crosta terrestre são desagregados e transportados por agentes da natureza como água, vento e gelo, podendo ser acelerado ou mesmo provocados por ações antrópicas. O presente trabalho é composto pelo levantamento de dados geograficos que permite a análise de trechos mais propensos ao surgimento de processos erosivos as margens da rodovia TO-445, entre as cidades de Miracema e Lajeado do Tocantins, no estado do Tocantins. Buscando entender como as variáveis do meio físico interagem e atuam no desenvolvimento das erosões próximas a rodovia e as patologias (defeitos) presentes na capa asfáltica da via, foram realizados o levantamento bibliográfico e a análise de dados disponibilizados pela SEFAZ, TOPODATA e INPE, sendo os dados processando-os por meio do Sistemas de Informação Geográfica (SIG) através do software QGIS. As áreas com presença de processos erosivos, foram identificadas por meio de geoprocessamentos utilizando-se imagens de satélite via Google Earth Pro. Através da correlação entre mapas de Curvatura vertical e horizontal, formas do terreno, declividade, hipsometria, geologia, geomorfologia, solos e uso e ocupação, foi possível compreender o comportamento dos fatores que influenciar e causar processos de erosão as margens da rodovia, bem como os pontos mais propensos ao surgimento de patologias na faixa de rolamento da rodovia em estudo.
Therapeutic Options for Mucopolysaccharidosis II (Hunter Disease)
Authors: Kubaski Francyne , Vairo Filippo , Baldo Guilherme , de Oliveira Poswar Fabiano , Corte Amauri Dalla , Giugliani Roberto
Published: August 2020

Background:

Mucopolysaccharidosis type II (Hunter syndrome, or MPS II) is an X-linked lysosomal disorder caused by the deficiency of iduronate-2-sulfatase, which leads to the accumulation of glycosaminoglycans (GAGs) in a variety of tissues, resulting in a multisystemic disease that can also impair the central nervous system (CNS).

Objective:

This review focuses on providing the latest information and expert opinion about the therapies available and under development for MPS II.

Methods:

We have comprehensively revised the latest studies about hematopoietic stem cell transplantation (HSCT), enzyme replacement therapy (ERT - intravenous, intrathecal, intracerebroventricular, and intravenous with fusion proteins), small molecules, gene therapy/genome editing, and supportive management.

Results and Discussion:

Intravenous ERT is a well-established specific therapy, which ameliorates the somatic features but not the CNS manifestations. Intrathecal or intracerebroventricular ERT and intravenous ERT with fusion proteins, presently under development, seem to be able to reduce the levels of GAGs in the CNS and have the potential of reducing the impact of the neurological burden of the disease. Gene therapy and/or genome editing have shown promising results in preclinical studies, bringing hope for a “one-time therapy” soon. Results with HSCT in MPS II are controversial, and small molecules could potentially address some disease manifestations. In addition to the specific therapeutic options, supportive care plays a major role in the management of these patients.

Conclusion:

At this time, the treatment of individuals with MPS II is mainly based on intravenous ERT, whereas HSCT can be a potential alternative in specific cases. In the coming years, several new therapy options that target the neurological phenotype of MPS II should be available.
An Insight in Pathophysiological Mechanism of Alzheimer’s Disease and its Management Using Plant Natural Products
Authors: Firdaus Zeba , Singh Tryambak Deo
Published: August 2020

Alzheimer’s disease (AD) is an age-associated nervous system disorder and a leading cause of dementia worldwide. Clinically, it is described by cognitive impairment and pathophysiologically by deposition of amyloid plaques and neurofibrillary tangles in the brain and neurodegeneration. This article reviews the pathophysiology, course of neuronal degeneration, and the various possible hypothesis of AD progression. These hypotheses include amyloid cascade, tau hyperphosphorylation, cholinergic disruption, metal dysregulation, vascular dysfunction, oxidative stress, and neuroinflammation. There is an exponential increase in the occurrence of AD in the recent few years that indicate an urgent need to develop some effective treatment. Currently, only 2 classes of drugs are available for AD treatment, namely acetylcholinesterase inhibitor and NMDA receptor antagonist. Since AD is a complex neurological disorder and these drugs use a single target approach, alternatives are needed due to limited effectiveness and unpleasant side-effects of these drugs. Currently, plants have been used for drug development research especially because of their multiple sites of action and fewer side effects. Uses of some herbs and phytoconstituents for the management of neuronal disorders like AD have been documented in this article. Phytochemical screening of these plants shows the presence of many beneficial constituents like flavonoids, triterpenes, alkaloids, sterols, polyphenols, and tannins. These compounds show a wide array of pharmacological activities, such as anti-amyloidogenic, anticholinesterase, and antioxidants. This article summarizes the present understanding of AD progression and gathers biochemical evidence from various works on natural products that can be useful in the management of this disease.
Epigenetic Evaluation of N-(2-hydroxyphenyl)-2-Propylpentanamide, a Valproic Acid Aryl Derivative with Activity Against HeLa Cells
Authors: Luna-Palencia G.R. , Correa-Basurto J. , Trujillo-Ferrara J. , Meraz-Ríos M.A. , Vásquez-Moctezuma I.
Published: August 2020

Background:

Valproic acid (VPA) is an HDAC inhibitor (HDACI) with an anticancer
activity, but is hepatotoxic. N-(2-hydroxyphenyl)-2-propylpentanamide (o-OH-VPA) is a VPA aryl
derivative designed in silico as a selective inhibitor of HDAC8 with biological properties against
HeLa, rhabdomyosarcoma and breast cancer cell cultures.

Objective:

We studied the epigenetic mechanism of o-OH-VPA as an HDACI and evaluated
whether it was toxic to normal cells.

Methods:

HeLa cells and primary human fibroblasts were used for this study as carcinogenic and
normal cells, respectively. Cell survival was evaluated by MTT assay, whereas viability and doubling
time were determined by the Trypan-blue method. HDAC activity was tested using the colorimetric
HDAC activity assay. The expression of p21 was analyzed by PCR and HDAC8 expression
was also evaluated by real-time PCR. Cell cycle and caspase-3 activity were analyzed by flow cytometry
and caspase-3 colorimetric assay, respectively.

Results:

o-OH-VPA (IC50 = 0.1 mM) was fifty-eight times more effective than VPA (IC50 = 5.8
mM) to reduce HeLa cell survival. Furthermore, o-OH-VPA increased the doubling time of HeLa
cells by 33% with respect to the control. o-OH-VPA acted as HDACI in HeLa cells without affecting
the HDAC8 expression, arresting the cell cycle of HeLa cells in the G0/G1 phase due to the increase
in p21 expression with the inhibition of caspase-3 activity without exhibiting toxicity toward
normal cells.

Conclusion:

Our results revealed that o-OH-VPA is an HDACI with a selective effect against
HeLa cells but without the known toxicity exerted by most pan-HDACIs on normal cells.
Recent Nanocarrier Approaches for Targeted Drug Delivery in Cancer Therapy
Authors: Bhatia Rohit , Sharma Amit , Narang Raj K. , Rawal Ravindra K.
Published: August 2020

Cancer is one of the most serious health concerns in the 21st century whose prevalence is
beyond boundaries and can affect any organ of the human body. The conventional chemotherapeutic
treatment strategies lack specificity to tumors and are associated with toxic effects on the immune
system and other organ systems. In the past decades, there has been continuous progress in
the development of smart nanocarrier systems for target-specific delivery of drugs against a variety
of tumors, including intracellular gene-specific targeting. These nanocarriers are able to recognize
the tumor cells and deliver the therapeutic agent in fixed proportions, causing no or very less harm
to healthy cells. Nanosystems have modified physicochemical properties, improved bioavailability,
and long retention in blood, which enhances their potency. A huge number of nanocarrier based formulations
have been developed and are in clinical trials. Nanocarrier systems include polymeric micelles,
liposomes, dendrimers, carbon nanotubes, gold nanoparticles, etc. Recent advancements in
nanocarrier systems include mesoporous silica nanoparticles (MSNs), metal organic frameworks,
and quantum dots. In the present review, various nanocarrier based drug delivery systems, along
with their applications in the management of cancer, have been described with special emphasis on
MSNs.
Graphene-based Room Temperature Gas Sensing Materials
Authors: Liang Hongping , Hu Huiyun , Wang Jianqiang , Li Hao , de Rooij Nicolaas Frans , Zhou Guofu , Wang Yao
Published: August 2020

Gas sensing materials essentially dominate the performances of the gas sensors which are
widely applied in environmental monitoring, industrial production and medical diagnosis. However,
most of the traditional gas sensing materials show excellent performances only at high operating
temperatures, which are high energy consumptive and have potential issues in terms of reliability
and safety of the sensors. Therefore, the development of Room Temperature (RT) gas sensing materials
becomes a research hotspot in this field. In recent years, graphene-based materials have been
studied as a class of promising RT gas sensing materials because graphene has a unique twodimensional
(2D) structure with high electron mobility and superior feasibility of assembling with
other “guest components” (mainly small organic molecules, macromolecules and nanoparticles).
More interestingly, its electrical properties become even more sensitive toward gas molecules at RT
after surface modification. In this review, we have summarized the recently reported graphenebased
RT gas sensing materials for the detection of NO2, H2S, NH3, CO2, CO, SO2, Volatile Organic
Compounds (VOCs) (i.e. formaldehyde, acetone, toluene, ethanol), as well as Liquefied Petroleum
Gas (LPG) and highlighted the latest researches with respect to supramolecular modification of graphene
for gas sensing. The corresponding structural features and gas sensing mechanisms of the
graphene-based gas sensors have also been generalized.
A Comparative Clinical Study on the effect of Ajmodadi Churna and Kati Basti in the management of Gridhrasi w.s.r. to Sciatica
Authors: Parida Akhilanath , Jena Satyasmita
Published: August 2020

In Ayurveda, Gridhrasi is considered as one of the Vataja Nanatmaja Vyadhi having vitiation of Vata and sometimes Vata Kapha Dosha. The cardinal signs and symptoms of Gridhrasi are Ruk (pain), Toda (pricking sensation), Stambha (stiffness) and Muhurspandan in the Sphika, Kati, Uruh, Janu, Jangha and Pada in order and Sakthiuthkshepanigraha (hinderence in lifting of the legs). In Kaphanubandha -Tandra, Gaurav, Arochaka are present. The signs and symptoms of ‘Gridhrasi’ can be correlated with that of ‘Sciatica’ in modern terminology. Sciatica is a very painful condition in which pain begins in lumbar region and radiates along the posterior lateral aspects of thigh and leg along with difficulty in walking. SLR test, sitting test, Lasegues sign are helpful not only to diagnose the sciatica but also to assess the progress of the therapy. With reference to the management of Sciatica, in modern medicine, various modalities are available. These modern therapies have their own limitations and these management tools are not affordable for the poor, especially in the developing countries. Therefore, the choice of treatment commonly opens to reveal some effective, simple, safe and economic modalities. Total 30 patients were registered in this study. 15 patients were assigned to group A (Ajmodadi Churna) and 15 to group B (Ajmodadi Churna and Sahacharadi Taila Kati Basti). Each patient was examined thoroughly before treatment and observed keenly during the procedure and follow up.
Role of Panchakarma in the management of Hypothyroidism
Authors: Kumbar Dr.Suraj , BA Dr.Lohith , M Dr.Ashvinikumar , R Dr. Amritha , Banu Dr. Shameem
Published: August 2020

We are in technical era where there is more of sedentary life style and stress along with this urbanization is affecting our quality of food and health. This is leading to many lifestyle disorders and hormonal imbalances in our body. Hypothyroidism one among the endocrinal disorder. Thyroid is an endocrinal gland secrets T3 and T4 hormones regulated by TSH which is secreted by Pituitary gland. These hormones have two major effects on the body, 1) To increase the overall metabolic rate in the body 2) To stimulate growth in children. Hypothyroidism is common health issue in India. The highest prevalence of hypothyroidism (13.1%) is noted in people aged 46-54yrs old. With people aged 18-35 yrs being less affected (7.5%). To prevent these hazards Panchakarma is beneficiary to maintain metabolic rate. Here an attempt is made to diagnose hypothyroidism in the light of Ayurveda and management guidelines through Panchakarma.
Nidana Panchaka - A tool of diagnosis in Ayurveda
Authors: Sawant Dr. Varun , . Dr. Ashu , Parida Dr. Akhilanath , Prasad Dr.N. A.
Published: August 2020

Nidana Panchaka is one of the many methods of diagnosis in Ayurveda. It is the most important method to diagnose disease, know its causes and predict its prognosis. Nidana Panchaka consists of five things which are Nidana (etiological factors), Purvaroopa (primordial symptoms), Roopa (signs and symptoms), Upashaya (like and dislike) and Samprati (etiopathogensis). Diagnosis of disease depends on Tridoshas which are Vata, Pitta, Kapha which are responsible for every disease that occurs in the body. These imbalances in the body Doshas are due to etiological factors such as lifestyle and eating habits of a person. Prior diagnosis is essential before one goes for the treatment of disease. There are many other techniques which are used for the diagnosis of the disease like Ashtavidha Pareeksha, Dashavidha Pareeksha, Chaturvidha Pareeksha, but this article is only concerned with importance of Nidana Panchaka.
Critical anatomical review of Tarunasthi (cartilage tissue) in Ayurveda
Authors: Banarase Dr. Rahul Shamrao
Published: August 2020

The human anatomy (Shareera Rachana) is an important for allied health sciences. It is one of the fundamental subject to the health science. Acharyas like Sushruta, Charaka and Vagbhata were given importance to the knowledge of Rachana Shareera. Tarunasthis are consider as a bone in Ayurvedic science are synonymous to cartilages described in modern medical science. It comes under 5 types of Asthi. Its locations mentioned in Ayurvedic text are Ghrana, Karna, Greewa and Akshikosh. The description of Tarunasthi is sporadic and scattered all over in Ayurvedic texts. In this review of applied part of Tarunasthi and its importance in Sharira has been discussed.
Stay healthy this monsoon with Ayurvedic lifestyle modifications
Authors: Baragi Dr. Umapati C. , Ganer Dr.Jyoti M. , Baragi Dr. Pramod C.
Published: August 2020

Ritucharya is the term for the dietary and lifestyle regimens that are based on Earth's seasons. The belief is that illness can be prevented if diet and lifestyle reflect the changes in weather conditions. Ritucharya is the ancient Ayurvedic practice and is comprised of two words, “Ritu” which means season and “Charya” which means regimen or discipline. Ritucharya consists of lifestyle and Ayurvedic diet routine to cope with the bodily and mental impacts caused by seasonal changes as recommended by Ayurveda. Varsha Rutu (Monsoon) brings about vivid changes not only in the nature but also in the body. Our body is more susceptible to health issues during rainy season, because monsoon reduces the digestive fire in our body. Our body constantly gets affected with indigestion problems, viral fever, malaise etc. so we must keep our body resistant against such diseases. Hence this review article discusses the lifestyle modifications needed to preserve then body from diseases originating in Varsha Rutu.