bluuebunny/crossref_metadata_2025 huggingface dataset:
Objectively measured the impact of air pollution on physical activity and sedentary behavior in freshmen student in Beijing, China
Authors: Yu Hongjun , Wu Yin , Gordon Shelby Paige , Cheng Jiali , Chen Panpan , Wang Yangyang , Yu Miao
Published: August 2019

Background: Air pollution has become a major environmental health risk factor, notably in China. Air pollution potentially has the impact of human populations’ health behavior. Gaps in scientific literature remain regarding more accurately estimates the relationship between air pollution and sedentary behavior in China. The purpose of this study is to examine the effect of hourly air pollution on hourly physical activity (PA) and sedentary behavior (SB) among college students living in Beijing, China. The secondary aim was to examine such associations varied at specific time.
Methods : Participants were recruited included 340 freshmen students from Tsinghua University. Accelerometers provided PA measures, including moderate-to-vigorous physical activity (MVPA), walking steps, energy expenditure, and sedentary time for 7 consecutive days. Corresponding air pollution data collected by Beijing Municipal Ecological Environment Bureau in the closed site in Tsinghua University were measured to include average hourly air quality index (AQI) and PM 2.5 (µg/m³). Associations were estimated using linear individual fixed-effect regressions.
Results: A one level increase in hourly air quality index (AQI) was associated with an reduction in one-hour physical activity by 0.083 (95% confidence interval [CI] =-0.137, -0.029) minutes of MVPA, 8.822 (95% CI = -15.028, -2.617) walking steps, 0.653 (95% CI =-1.033, -0.273) kcals of energy expenditure. A 10µg/m³ increase in air pollution concentration in hourly PM 2.5 was associated with a reduction in one-hour physical activity by 0.021 (95% confidence interval [CI] =-0.033, -0.010) minutes of MVPA, 2.232 (95% CI = -3.548, -0.916) walking steps, 0.170 (95% CI =-0.250, -0.089) kcals of energy expenditure and an increase in one-hour sedentary behavior 0.045 (0.005, 0.0845). At specific time, stronger negative associations of AQI and PM 2.5 air pollution with PA at 8 am, 4 pm, 5 pm and 7 pm. Similarly, stronger positive associations of one hour AQI and PM 2.5 air pollution with SB at 8 am, 9 am, 11 am, and 7 pm.
Conclusions: Air pollution decrease physical activity and increases sedentary behavior among freshman students living in Beijing, China. The impact of air pollution on physical activity and sedentary behavior at a specific time was different.
Prevalence of preterm premature rupture of membrane and its associated factors among pregnant women admitted in Debre tabor general hospital, North West Ethiopia: A facility based cross-sectional study
Authors: Addisu Dagne sewyew , Melkie Abenezer , Biru shimels
Published: August 2019

Abstract
Background: Premature rupture of membrane is a significant cause of maternal and neonatal morbidity and mortality both in high and low income countries which accounts 5-10 % of all deliveries. Due to different factors associated with the quality of health care given and socio-economic factors, the effect of preterm premature rupture of membrane is worsen in low-income countries. However, very little evidence is known about the problem in Ethiopian particularly in the study area. Therefore, this study was aimed to determine the prevalence of preterm premature rupture of membrane and its associated factors among pregnant women admitted in Debre tabor general hospital.
METHODS: Facility based cross-sectional study was conducted at Debre tabor general Hospital from December 14 – June 20, 2019. A total of 424 mothers were included in the study. Systematic random sampling technique was used selected the study participants. A combination of chart review and interview were used to collect the data. Data entry and analysis were made by using Epi-data version 4.2 and SPSS versions 23 respectively. Both descriptive & analytical statistics were computed. Statistical significance was considered at P<0.05 and the strength of association were assessed by using adjusted odds ratio.
Result: The prevalence preterm premature rupture of membrane was found to be 13.7%. Pregnant women with abnormal vaginal discharge [AOR=5.30, 95%C1=2.07-13.52], urinary tract infection [AOR =2.62, 95%Cl =1.32-5.19], history of premature rupture of membrane [AOR =3.31, 95%Cl =1.32-8.27], vaginal bleeding [AOR =2.58, 95%Cl =1.14-5.82] and mid upper arm circumstance <23cm [AOR =6.26, 95%Cl =3.21-12.20] were found to be associated with preterm premature rupture of membrane.
Conclusions: The prevalence of preterm premature rupture of membrane was high. Abnormal vaginal discharge, urinary tract infection, vaginal bleeding, previous premature rupture of membrane and mid upper arm circumstance <23cm were factors associated with an increased risk for preterm premature rupture of membrane. Thus, early screening, diagnosis and quickly treatments of urinary tract infection and abnormal vaginal discharges during pregnancy were recommended to reduce the risk of preterm premature rupture of membrane.
Keywords: premature rupture of membrane, prevalence, Debre tabor general hospital, risk factors
Multi-Drug Resistant, Extended Spectrum beta-Lactamase and Carbapenemase Producing Bacterial Isolates among Septicemia Suspected under Five Children in Tikur Anbesa Specialized Hospital, Addis Ababa Ethiopia: Cross-sectional study
Authors: Mitiku Mequanint , Ayenew Zeleke , Desta Kassu
Published: August 2019

Background: Bloodstream infections due to bacterial pathogens are a major cause of morbidity and mortality among pediatric patients. Emergence of drug resistance in high classes of antibiotics among the bacterial pathogens is another issue of the public health concern. Therefore this study aimed to determine Multi-drug resistant, extended spectrum β-lactamase and carbapenemase producing bacterial isolates among septicemia suspected under five Children in Tikur Anbesa Specialized Hospital, Addis Ababa Ethiopia. Methods: Across-sectional study was conducted from September 2017 to June 2018 among pediatric patients with febrile illness aged under five in Tikur Anbesa Specialized Hospital. Three hundred forty blood samples were collected and processed following standard microbiological techniques and culture was performed using BacT/Alert machine in combination with conventional method. AST of the isolates was performed by Kirby-Bauer disc diffusion method and MIC technique Result: A total of 137(40.2%) bacterial pathogens were isolated from 340 pediatric patients suspected of BSI with febrile illness. Of these isolates 54% were Gram negative bacteria. Of the isolates 43 (31.4%) Klebsiella pneumoniae and Acinitiobactor species were the most frequently isolated pathogens. Klebsiella pneumoniae isolates were 95.6% MDR, 23.7% ESBL, and 27.1% CRE in children. Conclusion: In this study, Klebsiella pneumoniae and S. aureus are common pathogens associated with BSI in pediatrics with high antimicrobial resistance. The prevalence of MDR 51.1%, CRE 30.5% and ESBL 25.4% were alarmingly high in bacterial isolates. ESBL producing organisms were common in Klebsiella species and Escherichia coli isolates. Since most of isolates exhibit multidrug resistant, invitro- susceptibility of antimicrobials is mandatory. Strengthen antimicrobial surveillance system and antimicrobial stewardship are necessary for better management of antibiotics in addition to infection prevention practice in TASH settings. Key words: Blood stream infection, BacT/Alert, multi-drug resistance, Extended spectrum beta-lactamase, Carbapenem resistance entrobacteriaciae.
Small RNA-seq analysis of exosomes from porcine uterine luminal fluid during peri-implantation
Authors: Hua Renwu , Wang Yueying , Lian Weisi , Li Wenchao , Xi Yu , Xue Songyi , Kang Tingting , Lei Minggang
Published: August 2019

Background

The exosomes of uterine luminal fluid (ULF) mediate intrauterine communication between conceptus and uterus in pigs. The small RNAs of ULF exosomes are widely recognized as important factors that influence embryonic implantation in humans, mice, cattle and sheep. Therefore, it can be hypothesized that small RNAs of ULF exosomes are essential for implantation in pigs.

Results

Cup-shaped exosomes (diameters: 40–160 nm) of porcine ULF were isolated and characterized, and then PKH67 stained exosomes were taken up by endometrial epithelial cells and porcine trophectoderm cells. The expression of small RNAs in these exosomes on days 10 (D10), 13 (D13) and 18 (D18) of pregnancy was comprehensively profiled through sequencing. From nine libraries, a total of 152 known microRNAs (miRNAs), 43 novel miRNAs and 145 novel Piwi-interacting RNAs (piRNAs) were identified. Among these small RNAs, ssc-miR-21-5p, ssc-let-7a, ssc-let-7i-5p and ssc-let-7g were differentially and highly expressed during the three stages. Hierarchical cluster analysis and principal component analysis suggested that the expression profiles of small RNAs in D13 group were different from those in D10 and D18 groups. Bioinformatics analysis showed that the miRNAs differentially expressed in the comparisons between D10 and D13, D13 and D18, and D10 and D18 groups were involved in important molecular functions and pathways such as “G-protein coupled receptor activity” and “Insulin signaling pathway”.

Conclusions

Our results reveal that porcine ULF exosomes contain various small RNAs with potentially vital effects on implantation. This research also provides resources for studies of miRNAs and piRNAs in the cross-talk between embryo and endometrium.
The efficacy of iCBT added to treatment as usual for alcohol dependent patients in Primary Care: study protocol for a randomized controlled trial.
Authors: Hyland Karin , Hammarberg Anders , Hedman-Lagerlöf Erik , Johansson Magnus , Andreasson Sven
Published: August 2019

Introduction
Alcohol dependence is a common disorder with a continuum regarding severity. Most alcohol dependent persons have a moderate level of dependence and live under socially orderly conditions. Treatment seeking in this group is low, mainly due to stigma and because treatment options are seen as unappealing. Alcohol is a relevant topic to discuss in many primary care (PC) consultations and PC is less stigmatizing to visit compared to addiction care units for people with alcohol problems. General practitioners (GP) hesitate to engage in treating alcohol problems due to time constraints and lack of knowledge. Screening and brief interventions are effective for high consumers but there are few studies on dependence.
Methods
This is a two-group, parallel, randomized controlled trial (RCT). The aim is to study whether an Internet based Cognitive Behavioral Treatment (iCBT) when added to treatment as usual (TAU) is more effective than TAU only for alcohol dependence in PC. 260 adults with alcohol dependence will be included. Participants are randomized to iCBT and TAU or TAU only. The primary study outcome is alcohol consumption in grams per week and heavy drinking days. Secondary outcomes include alcohol related problem severity, number of diagnostic criteria for alcohol dependence, depression and anxiety symptoms, health related quality of life and biochemical markers for high consumption and liver pathology. Data will be analysed using mixed-effect models.
Discussion
Internet based interventions are attractive to and have been shown to reach people with alcohol problems. Yet there are no studies investigating the efficacy of internet treatment of alcohol dependence in PC. In this study we hypothesize that iCBT when added to TAU will improve treatment outcome for alcohol dependence in PC, compared to TAU only. If effective, iCBT can be distributed to the public to a low cost for a stakeholder and has the opportunity to reduce both short term and long-term public health costs.
Trial registration: ISRCTN69957414. Retrospectively registered 07/06/2018. http://www.isrctn.com/ISRCTN69957414
Kinetic characterization of inhibitors of histone deacetylases (HDACs) and sirtuins
Authors: Moreno-Yruela Carlos , Madsen Andreas Stahl , Olsen Christian A.
Published: August 2019

Histone deacetylase (HDAC) inhibitors are employed for the treatment of lymphoma and are under development against multiple other types of cancer and neurodegenerative diseases. Here, we describe a robust and uncomplicated in vitro assay for HDAC inhibitor kinetic profiling. Enzyme and fluorogenic peptide substrate are incubated together with a small amount of protease “assay developer”, which enables continuous recording of substrate conversion under steady-state conditions. Assay progression curves upon addition of an inhibitors at varying concentrations permit determination of kinetic constants and overall inhibitor potency. This assay helped provide new insight into the kinetic properties of known HDAC inhibitors as well as the kinetic characterization of both inhibitors and substrates of sirtuin enzymes, which are class III HDACs involved in metabolic control and oncogene regulation.
Genetic Diversity and Epidemiology of Genogroup II Noroviruses in Children with Acute Sporadic Gastroenteritis in Shanghai, China, 2012-2017
Authors: Lu Lijuan , Zhong Huaqing , Xu Menghua , Su Liyun , Cao Lingfeng , Jia Ran , Xu Jin
Published: August 2019

Background Noroviruses (NoVs) are considered an important cause of acute gastroenteritis (AGE) across all age groups, especially in children under five years of age. We investigated the epidemiology of noroviruses in outpatient children from the Children’s Hospital of Fudan University in Shanghai, China. Methods Stool specimens were collected between January 2012 and December 2017 from 1433 children under ﬁve years of age with acute gastroenteritis. All samples were analysed by conventional reverse transcription-polymerase chain reaction (RT-PCR) for genogroup II NoVs amplifying both the RNA-dependent RNA polymerase (RdRp) and partial capsid genes. The Norovirus Genotyping Tool v.2.0 (https://www.rivm.nl/mpf/typingtool/norovirus/) was used for genotyping the strains, and phylogenetic analyses were conducted by MEGA 6.0. Results From 2012 to 2017, GII NoVs were detected in 15.4% (220/1433) of the samples, with the highest detection rate in children aged 7-12 months (19.2%, 143/746). The seasons with the highest prevalence of GII NoVs infection were autumn and winter . Based on genetic analysis of RdRp, GII.Pe (74.5%%, 137/184) was the most predominant RdRp genotype from 2013 to 2017, while GII.P4 played a dominant role in 2012 (55.6%, 21/36). Among the capsid genotypes, the most prevalent NoV genotype from 2012 to 2017 was GII.4 (73.6%, 162/220). On the basis of genetic analysis of RdRp and capsid sequences, the strains were clustered into 19 RdRp/capsid genotypes, and 12 of them were discordant, such as GII.Pe/GII.4-Sydney_2012, GII.P12/GII.3, GII.P7/GII.6, GII.Pe/GII.3, and GII.P16/GII.2. Starting with 2013, GII.Pe/GII.4-Sydney_2012 had completely replaced the pandemic GII.P4-2006b/GII.4-2006b subtype and was detected in children across all age groups. Conclusions The present study shows high detection rates and the genetic diversity of circulating NoV GII genotypes in paediatric AGE samples from Shanghai. The findings emphasize the importance of continuous molecular surveillance of emerging NoV strains. Keywords: Norovirus, RdRp/capsid genotypes, Epidemiology, Children, Acute gastroenteritis
The impact of working capital management on cash holdings of large and small firms: evidence from Jordan
Authors: Fawzi Shubita Mohammad
Published: August 2019

Liquidity is a firm’s ability to pay its current obligations as they come due and thus remain in business in the short run, which reflects the ease with which assets can be converted to cash. The objective of working capital management (WCM) is to minimize the cost of maintaining liquidity while guarding against the risk of insolvency, working capital policy applies to short-term decisions, and capital structure finance applies to long-term decisions.Several studies have been conducted on the impact of WCM on cash holding levels. The impact of WCM on liquidity and cash holding levels is analyzed in this study. The study also makes a comparison between large- and small-scale firms. Panel data for 62 Jordanian industrial firms covering an eleven-year period (2006–2016) have been analyzed. The descriptive analysis indicates that large firms hold more cash than small firms, as well as more debt, cash flow and growth.The findings of the data set indicate that WCM, as a variable (working capital net of cash), is a strong predictor of firm cash holding levels. When a firm has several cash substitutes, it will maintain low cash levels. The separate analysis shows that there are significant differences between small- and large-scale firms for determinates related to cash holding levels. Firm size and cash flow ratios were strong predictors of cash holding levels for both samples.
THE EFFECT OF CARDIORESPIRATORY FITNESS AND FATIGUE LEVEL ON LEARNING ABILITY OF MOVEMENT COORDINATION
Authors: Kriswanto Erwin Setyo , Setijono Hari , Mintarto Edy
Published: August 2019

This research aims to prove: 1) relationship between cardiorespiratory fitness with movement coordination learning ability, 2) relationship between cardiorespiratory fitness with fatigue level, and 3) relationship between cardiorespiratory fitness and fatigue level on learning ability of movement coordination. Samples were 30students of Department of Sport Education determined by purposive sampling technique.To conduct the correlational research, the instruments includeda Cardiorespiratory fitness measured by using Fitmate version 2.2, Wellness Technology a Division of Cosmed, also equipped with other supporting devices such as treadmills. Level of fatigue was measured by using the heart rate monitor of Polar brand and Stopwatch (BT Butterfly 60 Japan) while movement coordination learning ability measured by using Drawing Mirror Tracer Test. Using multiple regression analysis, it is concluded that: firstly, there is significant relationship between cardiorespiratory fitness and learning ability of movement coordination. Secondly, there is significant relationship between the level of fatigue and the learning ability of movement coordination. Thirdly, there is significant relationship between cardio respiratory fitness and level of fatigue in the learning ability of movement coordination.
Evaluación de extractos de hierbas y el óxido de germanio como adyuvantes inmunológicos en codornices (Coturnix coturnix japonica)
Authors: Bižanov Gazim , Normantienė Teresa , Jonauskienė Irena , Vyšniauskis Gintautas
Published: August 2019

Objetivo. El objetivo de la presente investigación fue evaluar la actividad inmunoestimulante de extractos de hierbas de Allium sativum, Aloe arborescens y óxido de germanio. Materiales y métodos. Las codornices se inmunizaron tres veces por vía oral con albúmina de suero bovino (BSA) en combinación con los extractos vegetales crudos y la sustancia inorgánica antes indicada. Los anticuerpos IgA específicos de la BSA en la saliva y los anticuerpos IgY en la yema de huevo se analizaron mediante ELISA. Resultados. Se encontró que las aves tratadas con BSA en combinación con extractos de Allium sativum o Aloe arborescens o con óxido de germanio tenían títulos más altos de anticuerpos IgA específicos de BSA en la saliva a los 42 días de seguimiento, mientras que las codornices administradas con BSA y Allium sativum o extractos de Aloe arborescens u óxido de germanio demostraron niveles más altos de anticuerpos IgY específicos de BSA en la yema de huevo al final de la observación. Además, las aves inmunizadas sólo con BSA tuvieron respuestas inmunitarias significativamente más bajas a la BSA que las codornices inmunizadas con BSA complementadas con extractos de hierbas y óxido de germanio. Conclusiones. Estos datos sugieren que los extractos de plantas medicinales y el óxido de germanio pueden aplicarse como adyuvantes orales o como inmunomoduladores para las codornices.
Evaluación de medicamentos homeopáticos en la supervivencia y respuesta antioxidante del camarón blanco Litopenaeus vannamei infectado con Vibrio parahaemolyticus
Authors: Mazón-Suástegui José , García-Bernal Milagro , Avilés-Quevedo María Araceli , Campa-Córdova Ángel , Salas-Leiva Joan , Abasolo-Pacheco Fernando
Published: August 2019

Objetivo. Evaluar el efecto de medicamentos homeopáticos sobre la supervivencia y actividad de la enzima superóxido dismutasa (SOD) del camarón Litopenaeus vannamei sometido a infección con Vibrio parahamolyticus. Materiales y Métodos. Se determinó la dosis letal media (DL50) para la cepa patógena en juveniles de L. vannamei, bajo los método de inmersión (Inm), inyección (Iny) e incisión + inmersión (Inc+Inm).Luego el efecto de cuatro medicamentos homeopáticos sobre juveniles de L. vannamei retados con Vibrio parahaemolyticus fue evaluado usando el índice la supervivencia y la actividad SOD. Se aplicaron cuatro tratamientos: (1) Mezcla CIB®-HOM Heel-Mix (TH1), constituido por igual proporción v/v, de Cyme-Heel®, Gal-Heel®, Hepa-Heel®, Mucs-Heel® y Chol-Heel®; (2) Mezcla CIB®-HOM Pav-Mix (TH2), constituido por igual proporción v/v de Passiflora incarnata, Valeriana officinalis, Zincum valerianicum e Ignatia amara (Similia®); (3) Heel-Mix/Pav-Mix (TH3) constituido por una combinación 1:1 v/v de los tratamientos TH1 y TH2, y (4) ViT-Mix (TH4), constituido por Vidatox®, y un control (no tratado/infectado). Resultados. Al aplicar los método Inm, Iny e Inc+Inm la DL50 fue de 0.9 x 106; 0.6 x 106 y 0.5 x 106 UFC.mL-1, respectivamente. Los camarones tratados con TH3 y TH4 presentaron una mayor actividad de SOD con respecto al grupo control (p<0.05). Al final del reto, los grupos TH2, TH3 y TH4 tuvieron una supervivencia mayor a la del grupo control (p<0.05). Conclusiones. Los tratamientos homeopáticos (TH3 y TH4), aumentaron la actividad de la enzima SOD y la supervivencia en juveniles de L. vannamei, retados con V. parahaemolyticus. Esto sugiere que los tratamientos homeopáticos empleados tienen potencial como alternativa para el control de V. parahaemolyticus y sus enfermedades asociadas, incluido el síndrome de mortalidad temprana en el cultivo del camarón
Osteosarcoma periosteal en perro - Informe de caso
Authors: Noronha T Gabriela , Hough Monteiro Julio Edward , Casarin Costa Rodrigo , Oliveira Vasconcelos Rosemeri , Tinucci Costa Mirela
Published: August 2019

El osteosarcoma es el tumor óseo más común en los perros. Osteosarcoma periosteal es un subtipo de osteosarcoma y se considera raro en la especie canina.  El objetivo del presente estudio fue describir un caso de una perra mestiza de 14 años de edad con una masa ulcerada y localizada en la tibia derecha y 30 días de evolución. Él paciente se sometió a exámenes adicionales (análisis de sangre, dosis de enzimas bioquímicas - creatinina y alanina aminotransferasa, radiografías torácicas y ultrasonografía abdominal) para la estadificacion completa de la enfermedad. La radiografía de la tibia derecha reveló reacción perióstica proliferativa y lítica. Él examen citológico de la masa sugirió un tumor de celulas redondas. La evaluación clínica y hallazgos radiológicos sugieren la presencia de una neoplasia ósea. La amputación de la extremidad pélvica derecha fue el tratamiento quirúrgico inicial sugerido al cliente. Él examen histopatológico reveló la presencia de osteosarcoma periosteal con márgenes libres y ganglios linfáticos sin evidencia de células tumorales. El seguimiento clínico se realizó a través de exámenes de imágenes sin evidencia de enfermedad metastásica. El perra tenía un tiempo de sobrevida de nueve meses desde el diagnóstico.
Adherence Reporting in Randomized Controlled Trials Examining Manualized Multisession Online Interventions: Systematic Review of Practices and Proposal for Reporting Standards
Authors: Beintner Ina , Vollert Bianka , Zarski Anna-Carlotta , Bolinski Felix , Musiat Peter , Görlich Dennis , Ebert David Daniel , Jacobi Corinna
Published: August 2019

Background

Adherence reflects the extent to which individuals experience or engage with the content of online interventions and poses a major challenge. Neglecting to examine and report adherence and its relation to outcomes can compromise the interpretation of research findings.

Objective

The aim of this systematic review is to analyze how adherence is accounted for in publications and to propose standards for measuring and reporting adherence to online interventions.

Methods

We performed a systematic review of randomized controlled trials on online interventions for the prevention and treatment of common mental disorders (depression, anxiety disorders, substance related disorders, and eating disorders) published between January 2006 and May 2018 and indexed in Medline and Web of Science. We included primary publications on manualized online treatments (more than 1 session and successive access to content) and examined how adherence was reported in these publications.

Results

We identified 216 publications that met our inclusion criteria. Adherence was addressed in 85% of full-text manuscripts, but only in 31% of abstracts. A median of three usage metrics were reported; the most frequently reported usage metric (61%) was intervention completion. Manuscripts published in specialized electronic health journals more frequently included information on the relation of adherence and outcomes.

Conclusions

We found substantial variety in the reporting of adherence and the usage metrics used to operationalize adherence. This limits the comparability of results and impedes the integration of findings from different studies. Based on our findings, we propose reporting standards for future publications on online interventions.
Nutritional Assessment of Childhood Cancer Survivors (the Swiss Childhood Cancer Survivor Study-Nutrition): Protocol for a Multicenter Observational Study
Authors: Belle Fabiën Naomi , Beck Popovic Maja , Ansari Marc , Otth Maria , Kuehni Claudia Elisabeth , Bochud Murielle
Published: August 2019

Background

Childhood cancer survivors are at high risk of developing adverse late health effects. Poor nutritional intake may contribute to this risk, but information about dietary intake is limited.

Objective

This study will assess childhood cancer survivors’ dietary intake and compare two dietary assessment tools: a self-reported food frequency questionnaire, and dietary measurements from urine spot samples.

Methods

In a substudy of the Swiss Childhood Cancer Survivor Study (SCCSS), SCCSS-Nutrition, we assessed childhood cancer survivors’ dietary intake via a validated food frequency questionnaire. We sent a urine spot collection kit to a subset of 212 childhood cancer survivors from the French-speaking region of Switzerland to analyze urinary sodium, potassium, urea, urate, creatinine, and phosphate content. We will compare the food frequency questionnaire results with the urine spot analyses to quantify childhood cancer survivors’ intake of various nutrients. We collected data between March 2016 and March 2018.

Results

We contacted 1599 childhood cancer survivors, of whom 919 (57.47%) returned a food frequency questionnaire. We excluded 11 childhood cancer survivors who were pregnant or were breastfeeding, 35 with missing dietary data, and 71 who had unreliable food frequency questionnaire data, resulting in 802 childhood cancer survivors available for food frequency questionnaire analyses. To a subset of 212 childhood cancer survivors in French-speaking Switzerland we sent a urine spot collection kit, and 111 (52.4%) returned a urine sample. We expect to have the results from analyses of these samples in mid-2019.

Conclusions

The SCCSS-Nutrition study has collected in-depth dietary data that will allow us to assess dietary intake and quality and compare two dietary assessment tools. This study will contribute to the knowledge of nutrition among childhood cancer survivors and is a step toward surveillance guidelines and targeted nutritional recommendations for childhood cancer survivors in Switzerland.

Trial Registration

ClinicalTrials.gov NCT03297034; https://clinicaltrials.gov/ct2/show/NCT03297034

International Registered Report Identifier (IRRID)

DERR1-10.2196/14427
Associations Between Characteristics of Web-Based Diabetes News and Readers’ Sentiments: Observational Study in the Netherlands
Authors: Vehof Hans , Heerdink Eibert , Sanders José , Das Enny
Published: August 2019

Background

Although experts agree that Web-based health information often contains exaggeration and misrepresentation of science, it is not yet known how this information affects the readers’ sentiments.

Objective

This study aimed to investigate whether specific aspects of Web-based diabetes research news are associated with positive or negative sentiments in readers.

Methods

A retrospective observational study of the comments on diabetes research news posted on Facebook pages was conducted as a function of the innovations’ developmental phase, the intended treatment effect, and the use of strong language to intensify the news messages (superlatives). Data for the investigation were drawn from the diabetes research news posted between January 2014 and January 2018 on the two largest Dutch Facebook pages on diabetes and the corresponding reader comments. By manually coding these Facebook user comments, three binary outcome variables were created, reflecting the presence of a positive sentiment, the presence of a negative sentiment, and the presence of a statement expressing hopefulness.

Results

Facebook users made a total of 3710 comments on 173 diabetes research news posts that were eligible for further analysis. Facebook user comments on posts about diabetes prevention (odds ratio [OR] 0.55, 95% CI 0.37-0.84), improved blood glucose regulation (OR 0.68, 95% CI 0.56-0.84), and symptom relief (OR 0.31, 95% CI 0.21-0.44) were associated with less positive sentiments as compared with potential diabetes cures. Furthermore, comments on innovations supported by preclinical evidence in animals were associated with more positive sentiments (OR 1.46, 95% CI 1.07-1.99) and statements expressing hope (OR 1.47, 95% CI 1.01-2.14), when compared with innovations that have evidence from large human trials. This study found no evidence for the associations between language intensification of the news posts and the readers’ sentiments.

Conclusions

Our finding that the attitudes toward diabetes research news on Facebook are most positive when clinical efficacy is not (or not yet) proven in large patient trials suggests that news authors and editors, as well as medical professionals, must exercise caution when acting as a conduit for diabetes research news.
Targeting the Infant Gut Microbiota Through a Perinatal Educational Dietary Intervention: Protocol for a Randomized Controlled Trial
Authors: Dawson Samantha L , Craig Jeffrey M , Clarke Gerard , Mohebbi Mohammadreza , Dawson Phillip , Tang Mimi LK , Jacka Felice N
Published: August 2019

Background

The early life gut microbiota are an important regulator of the biological pathways contributing toward the pathogenesis of noncommunicable disease. It is unclear whether improvements to perinatal diet quality could alter the infant gut microbiota.

Objective

The aim of this study is to assess the efficacy of a perinatal educational dietary intervention in influencing gut microbiota in mothers and infants 4 weeks after birth.

Methods

The Healthy Parents, Healthy Kids randomized controlled trial aimed to recruit 90 pregnant women from Melbourne, Victoria, Australia. At week 26 of gestation, women were randomized to receive dietary advice from their doctor (n=45), or additionally receive a dietary intervention (n=45). The intervention included an educational workshop and 2 support calls aiming to align participants’ diets with the Australian Dietary Guidelines and increase intakes of prebiotic and probiotic foods. The educational design focused on active learning and self-assessment. Behavior change techniques were used to support dietary adherence, and the target behavior was eating for the gut microbiota. Exclusion criteria were age under 18 years, diagnosed mental illnesses, obesity, diabetes mellitus, diagnosed bowel conditions, exclusion diets, illicit drug use, antibiotic use, prebiotic or probiotic supplementation, and those lacking dietary autonomy. The primary outcome measure is a between-group difference in alpha diversity in infant stool collected 4 weeks after birth. Secondary outcomes include evaluating the efficacy of the intervention in influencing infant and maternal stool microbial composition and short chain fatty acid concentrations, epigenetic profile, and markers of inflammation and stress, as well as changes in maternal dietary intake and well-being. The study and intervention feasibility and acceptance will also be evaluated as secondary outcomes.

Results

The study results are yet to be written. The first participant was enrolled on July 28, 2016, and the final follow-up assessment was completed on October 11, 2017.

Conclusions

Data from this study will provide new insights regarding the ability of interventions targeting the perinatal diet to alter the maternal and infant gut microbiota. If this intervention is proven, our findings will support larger studies aiming to guide the assembly of gut microbiota in early life.

Trial Registration

Australian Clinical Trials Registration Number ACTRN12616000936426; https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=370939

International Registered Report Identifier (IRRID)

DERR1-10.2196/14771
Assessing Breast Cancer Survivors’ Perceptions of Using Voice-Activated Technology to Address Insomnia: Feasibility Study Featuring Focus Groups and In-Depth Interviews (Preprint)
Authors: Arem Hannah , Scott Remle , Greenberg Daniel , Kaltman Rebecca , Lieberman Daniel , Lewin Daniel
Published: August 2019

BACKGROUND

Breast cancer survivors (BCSs) are a growing population with a higher prevalence of insomnia than women of the same age without a history of cancer. Cognitive behavioral therapy for insomnia (CBT-I) has been shown to be effective in this population, but it is not widely available to those who need it.

OBJECTIVE

This study aimed to better understand BCSs’ experiences with insomnia and to explore the feasibility and acceptability of delivering CBT-I using a virtual assistant (Amazon Alexa).

METHODS

We first conducted a formative phase with 2 focus groups and 3 in-depth interviews to understand BCSs’ perceptions of insomnia as well as their interest in and comfort with using a virtual assistant to learn about CBT-I. We then developed a prototype incorporating participant preferences and CBT-I components and demonstrated it in group and individual settings to BCSs to evaluate acceptability, interest, perceived feasibility, educational potential, and usability of the prototype. We also collected open-ended feedback on the content and used frequencies to describe the quantitative data.

RESULTS

We recruited 11 BCSs with insomnia in the formative phase and 14 BCSs in the prototype demonstration. In formative work, anxiety, fear, and hot flashes were identified as causes of insomnia. After prototype demonstration, nearly 79% (11/14) of participants reported an interest in and perceived feasibility of using the virtual assistant to record sleep patterns. Approximately two-thirds of the participants thought lifestyle modification (9/14, 64%) and sleep restriction (9/14, 64%) would be feasible and were interested in this feature of the program (10/14, 71% and 9/14, 64%, respectively). Relaxation exercises were rated as interesting and feasible using the virtual assistant by 71% (10/14) of the participants. Usability was rated as better than average, and all women reported that they would recommend the program to friends and family.

CONCLUSIONS

This virtual assistant prototype delivering CBT-I components by using a smart speaker was rated as feasible and acceptable, suggesting that this prototype should be fully developed and tested for efficacy in the BCS population. If efficacy is shown in this population, the prototype should also be adapted for other high-risk populations.
THE ROLE OF KIAI LEADERSHIP AND CHARACTER EDUCATION: A PATTERN OF SANTRI CHARACTER FORMATION AT ASY-SYIFA AL-QUR'AN ISLAMIC BOARDING SCHOOL
Authors: Hafidh Zaini , Zuhri M. Tajudin , Sandi Wawan Kurniawan
Published: August 2019

This research departs from the actualization of the kiai's leadership role in santri character education in Islamic boarding schools, which consists of the role of goal rationality, spirituality, and interpretation of the vision of education in Islamic boarding schools. This research aims to describe the role of the kiai in forming the character of santri in the Asy-Syifa Islamic boarding school. This research used a qualitative approach with descriptive methods. data collection with interviews, observation and documentation studies, also data analysis and valid data testing. the results of research on how kiai act as pathfinding, a lightning and empowering in the process of forming the character of santri, this is illustrated by how the kiai synergizes the great vision of kiai and Islmic boarding school, with typical learning and Islamic boarding school culture and relational patterns of kiai-santri, santri-kiai and santri-community as a comprehensive process of character education patterns in the Asy-Syifa Islamic boarding school
Historia de la conquista, pérdida y restauración de la Nueva México. Escribiendo la historia oficial de la frontera norte del imperio español de acuerdo con Juan de Villagutierre y Sotomayor, relator del Consejo de Indias, 1706
Authors: Arias Ortiz Teri Erandeni , Segovia Liga Argelia
Published: August 2019

El siguiente trabajo tiene como objetivos revisar brevemente la vida de Juan de Villagutierre y Sotomayor, relator del Consejo de Indias a finales del siglo XVII e inicios del XVIII, y  explorar de forma general el contenido de una de sus obras dedicada a la historia de la entonces provincia de Nuevo México. Este manuscrito, muy poco conocido, es único en su género por varias razones; una de ellas es el hecho de que la obra puede considerarse como una revisión general del territorio y su gente, ya que incluye su historia indígena, hispánica, y colonial. La otra es que el discurso de la obra ofrece una interpretación secular de la historia,  por lo que los personajes principales que aparecen en la narración pertenecen a la esfera civil de la Corona española, y no a la religiosa.
Francisco Quijano Velasco, Las repúblicas de la Monarquía. Pensamiento constitucionalista y republicano en Nueva España, 1550-1610
Authors: Pastor Llaneza Marialba
Published: August 2019

Reseña del libro de Francisco Quijano donde aborda el pensamiento constitucionalista y republicano en Nueva España 1550-1610.
RELACIONANDO AS CARACTERISTICAS E FUNÇÕES DO ORÇAMENTO COM A SATISFAÇÃO ORÇAMENTÁRIA EM EMPRESA DE CONSULTORIA EMPRESARIAL
Authors: Defaveri Ivan Rafael , Santi Diego Grahl de , Toigo Leandro Augusto
Published: August 2019

O estudo investiga como as características, funções e satisfação dos orçamentos se relacionam em empresa prestadora de serviço. Tendo as funções dos orçamentos e características designadas no processo nas organizações para controle gerencial. Estudos consideram inclusive que a satisfação dos usuários do orçamento é um efeito mediador da percepção de justiça que estes têm do processo orçamentário. A participação orçamentária representa o envolvimento dos gerentes e demais componentes na construção dos orçamentos e definição de metas orçamentárias Para tanto, foi realizada uma pesquisa qualitativa, com entrevistas semiestruturadas aplicadas aos dois responsáveis pela coordenação do processo orçamentário de uma empresa localizada na cidade de Cascavel – PR. Os resultados indicam algumas características e funções apresentadas pelo processo orçamentário na empresa, e também fatores condicionantes de satisfação apresentados pelos participantes. Dentre os fatores mais relacionados com a satisfação estão aqueles relativos ao engajamento do funcionário com a empresa, como a participação e a avaliação de desempenho por meio do processo orçamentário, uma vez que os responsáveis pelo processo se mostram satisfeitos sobretudo pela possibilidade de estarem envolvidos, mostrando voz ativa e tomando parte no processo de gestão. O trabalho contribuiu na definição de fatores capazes de gerar satisfação no processo orçamentário, de modo a permitir uma visão que pode ser aplicada nas empresas, de forma a proporcionar processos mais viáveis para as organizações. Estudos futuros podem investigar o fenômeno por meio de uma perspectiva quantitativa, também testando a satisfação orçamentária como uma variável endógena.
DA PAIXÃO PELA COZINHA A VISÃO EMPREENDEDORA: O CASO DA BARRACA DO CARIOCA
Authors: Zonatto Patrinês Aparecida França , Sbissa Amanda Paterno , Rossetto Carlos Ricardo , Zonatto Vinícius Costa da Silva
Published: August 2019

Este caso para ensino tem como objetivo analisar as estratégias de crescimento e desenvolvimento para a Barraca de cachorro quente do Carioca, para que não encere suas atividades. A empresa está passando por sérios desafios financeiros e cada vez está mais difícil conseguir permanecer atuando neste ramo. Guiado pela paixão por cozinhar, o proprietário Carioca como é conhecido, decidiu abrir uma pequena barraca no mesmo terreno de sua casa, para vender lanches e bebidas. No entanto suas vendas não estão como ele esperava, seus custos aumentam dia-a-dia, e Carioca se vê frente uma decisão difícil: Será que é hora de se reposicionar no mercado? O caso para ensino pode ser utilizado como material didático em cursos de graduação e de pós-graduação em administração e áreas afins. A elaboração do texto seguiu uma metodologia apropriada para caso para ensino. O caso possibilita ao professor explorar temas como perfil empreendedor, competências empreendedoras, toma de decisão e a importância de um plano de negócios na constituição de uma empresa. Após análise da situação apresentada, os alunos são convidados a discutir sobre habilidades empreendedoras, propondo soluções eficazes para a tomada de decisão. O caso é finalizado com notas de ensino e sugestões de aplicação em aula.
DETERMINANTES DAS OSCILAÇÕES NO ENDIVIDAMENTO DAS EMPRESAS BRASILEIRAS
Authors: Sonza Igor Bernardi , Machado Vagner Naysinger , Lacruz Maria Silvia Pardi , Rosa Andrieli da Silva
Published: August 2019

As consequências das dificuldades financeiras podem ser severas para as empresas em momentos de crise, gerando impactos institucionais nos negócios e resiliência no mercado de capitais, o que leva a uma maior demora em superá-la. Por esse motivo, o presente artigo busca analisar os determinantes das oscilações na alavancagem das empresas brasileiras de capital aberto após a crise de 2008, identificando se os seus efeitos foram sentidos de forma diferenciada para grupos classificados de acordo com o nível de endividamento. Para esse fim, foram aplicadas análises de cluster e regressões lineares através de dados em painel não balanceados por GMM-Sys. Como resultado do estudo, foi identificado que, no pós-crise, as empresas ficaram mais receosas em buscar dívidas, também, os bancos começaram a ser mais rigorosos na concessão de crédito, sendo que as empresas maiores e mais arriscadas, com mais oportunidades de crescimento e menor rentabilidade, foram as mais suscetíveis a se endividarem nesse período.
AVALIAÇÃO DO DESPERDÍCIO DE ALIMENTOS E SUSTENTABILIDADE EM UNIDADES PRODUTORAS DE REFEIÇÕES NO MUNICÍPIO DE SÃO PAULO-SP
Authors: Gois Beatriz , Souza Beatriz , Hachul Letícia , Canongia Sofia , Spinelli Mônica Glória Neumann
Published: August 2019

O hábito de comer fora de casa tem relação com o crescimento socioeconômico do país, fazendo com que, cada vez mais surjam diversos estabelecimentos que comercializam refeições, conhecidos como Unidades Produtoras de Refeições (UPR). Um fator de grande importância nessas unidades é o desperdício de alimentos, que pode ser considerado sinônimo de falta de qualidade e deve ser evitado por meio de um planejamento adequado. Esse desperdício cada vez maior de resíduos, torna-se um dos maiores problemas da sociedade atual, trazendo impactos à saúde pública e ao meio ambiente. Assim, o objetivo deste trabalho foi investigar a geração de resíduos sólidos e sustentabilidade ambiental em unidades produtoras de refeições na cidade de São Paulo. Os dados foram coletados por meio de um questionário com perguntas relacionadas ao desperdício de alimentos, o destino das sobras e restos, do lixo reciclável, e do óleo utilizado, além de abordar o reaproveitamento dos alimentos, e ações de sustentabilidade realizadas. Dos resultados encontrados, pode-se perceber que há uma conscientização a respeito da economia de água, luz, além da coleta seletiva do lixo reciclável e dos óleos utilizados nos estabelecimentos. Em 100% dos estabelecimentos a maior origem de descarte de matéria-prima provém da etapa de pós-produção, o que resulta no provável desperdício de matérias orgânicas, visto que 100% dos estabelecimentos tem como destino de suas sobras o lixo.
INTERNAÇÕES POR DOENÇAS DO APARELHO CIRCULATÓRIO E A QUEIMA DE BIOMASSA FLORESTAL EM RESIDENTES DE PORTO VELHO RONDÔNIA ENTRE 2014 -2015
Authors: Torres Thiago De Lima , Medeiros Andréa Paula Peneluppi de
Published: August 2019

Estudos experimentais e observacionais têm apresentado evidências consistentes sobre os efeitos da poluição do ar, especialmente do material particulado fino, na morbidade e na mortalidade por doenças do aparelho circulatório. O presente estudo teve como objetivo estudar se a exposição aos poluentes do ar (monóxido de carbono e material particulado) e focos de queimadas estão associadas às internações hospitalares por algumas doenças do aparelho circulatório no município de Porto Velho - RO. Para tanto, realizou-se um estudo epidemiológico transversal dessas internações no município de Porto Velho - RO, no período entre setembro de 2014 e agosto de 2015. Os critérios de inclusão foram: pessoas hospitalizadas e residentes no município de Porto Velho - RO, diagnóstico principal da internação ser por Doenças do Aparelho Circulatório e estar acima de 39 anos de idade. Os dados sobre as internações foram adquiridos por meio do Sistema de Informações Hospitalares do SUS (SIH/SUS) do Departamento de Informática do Sistema Único de Saúde - DATASUS.  Já os dados sobre a poluição do ar e dos focos de queimadas foram obtidos a partir do banco de dados do Sistema de Informações Ambientais (SISAM). Realizou-se análise descritiva e regressão logística univariada, utilizando-se o Programa Stata 9.0. A análise constatou maior chance de duas ou mais internações ao dia quando da ocorrência de exposição ao PM2,5 no 4o quartil (OR=1,67 e OR= 2,95, respectivamente nos lags 2 e 6), para o CO, de maneira expressiva e com significância, no 4o quartil (OR=1,61; OR=1,55; OR=1,90; OR=2,21; OR=1,84; respectivamente nos lags 2, 4, 5, 6 e 7). Também chama a atenção os focos de queimadas no 4o quartil (OR= 1,90; OR=1,78; OR=1,85; OR=1,90; OR=4,59; OR=2,21, respectivamente nos lags 1, 2, 3, 4, 6 e 7), todos com p<0,05. Conclui-se que a exposição aos poluentes do ar (CO, PM2,5) e aos focos de queimadas pode estar associada ao aumento das internações hospitalares por doenças do aparelho circulatório no município de Porto Velho - RO.