bluuebunny/crossref_metadata_2025 huggingface dataset:
Collaborative Governance in Creative Economy Development: Role and Influence of Stakeholders in Parepare City
Authors: Suni Muhadjir , Taufik Muh , Isma Andika
Published: September 2024

Pengembangan ekonomi kreatif di Kota Parepare menghadapi tantangan dalam tata kelola kolaboratif antara berbagai pemangku kepentingan. Penelitian ini bertujuan untuk mengeksplorasi kondisi awal tata kelola kolaboratif, memetakan peran dan tanggung jawab pemangku kepentingan, serta mengidentifikasi tantangan dan kemajuan dalam sektor ekonomi kreatif di kota ini. Penelitian ini menggunakan pendekatan kualitatif dengan metode wawancara dan observasi. Data dikumpulkan dari 15 informan, termasuk pemerintah, pengusaha, komunitas, dan akademisi, selama periode dari 23 Juni hingga 5 Juli 2024. Lokasi penelitian meliputi berbagai titik di Kota Parepare yang terkait dengan ekonomi kreatif dan pariwisata. Studi ini menemukan bahwa meskipun pemerintah telah menunjukkan komitmen melalui pelatihan dan bimbingan teknis, tantangan dalam koordinasi dan ketidakpastian kebijakan masih menghambat kemajuan. Pertumbuhan UMKM yang positif dan upaya kolaboratif antara berbagai pemangku kepentingan menunjukkan potensi, namun sinergi yang lebih baik diperlukan untuk meningkatkan efektivitas strategi pengembangan. Untuk meningkatkan tata kelola kolaboratif dan mendorong pertumbuhan ekonomi kreatif, Kota Parepare perlu memperbaiki koordinasi antar pemangku kepentingan dan menyusun kebijakan yang lebih terarah. Kolaborasi yang harmonis dan dukungan berkelanjutan akan memperkuat ekosistem ekonomi kreatif di Parepare.
Model Pengembangan Akomodasi Berkelanjutan pada Kawasan Ekowisata Hutan Mangrove Lantebung
Authors: Rijal Muhammad Taufiq , Rijal Syamsu
Published: September 2024

Pengembangan ekonomi kreatif di Kota Parepare menghadapi tantangan dalam tata kelola kolaboratif antara berbagai pemangku kepentingan. Penelitian ini bertujuan untuk mengeksplorasi kondisi awal tata kelola kolaboratif, memetakan peran dan tanggung jawab pemangku kepentingan, serta mengidentifikasi tantangan dan kemajuan dalam sektor ekonomi kreatif di kota ini. Penelitian ini menggunakan pendekatan kualitatif dengan metode wawancara dan observasi. Data dikumpulkan dari 15 informan, termasuk pemerintah, pengusaha, komunitas, dan akademisi, selama periode dari 23 Juni hingga 5 Juli 2024. Lokasi penelitian meliputi berbagai titik di Kota Parepare yang terkait dengan ekonomi kreatif dan pariwisata. Studi ini menemukan bahwa meskipun pemerintah telah menunjukkan komitmen melalui pelatihan dan bimbingan teknis, tantangan dalam koordinasi dan ketidakpastian kebijakan masih menghambat kemajuan. Pertumbuhan UMKM yang positif dan upaya kolaboratif antara berbagai pemangku kepentingan menunjukkan potensi, namun sinergi yang lebih baik diperlukan untuk meningkatkan efektivitas strategi pengembangan. Untuk meningkatkan tata kelola kolaboratif dan mendorong pertumbuhan ekonomi kreatif, Kota Parepare perlu memperbaiki koordinasi antar pemangku kepentingan dan menyusun kebijakan yang lebih terarah. Kolaborasi yang harmonis dan dukungan berkelanjutan akan memperkuat ekosistem ekonomi kreatif di Parepare.
越南汉语学习者低龄化趋势：成因与现状分析——以胡志明市商业华语培训中心为例
Authors: Thu Lan Dang , Qian Li
Published: September 2024

In recent years, there has been a noticeable trend of younger learners taking up Chinese globally. Since the Vietnamese Ministry of Education included Chinese as an elective foreign language in primary schools in 2021, the number of primary and secondary school students learning Chinese has significantly increased. To gain a more comprehensive understanding of the current state of Chinese learning in Vietnamese primary and secondary schools, identify potential challenges in the process of younger learners taking up Chinese, and provide valuable data support for the formulation of long-term Chinese education development plans, this study uses the Hoavan SHZ Chinese Training Center as a case study. It explores the enrollment situation and operational status of young learners over the past ten years. Through data analysis and interviews, the study examines changes in the age groups of young learners, the causes of the trend toward younger learners, the prospects for development, and the challenges faced. The results show that the number of young Chinese learners in Vietnam has been steadily increasing, with the age of learners continuously decreasing, including preschool children starting to learn Chinese. National education policies and the deepening of China-Vietnam cooperation are the main driving forces. To respond to this trend and meet the needs of parents and students, this paper advocates cultivating students' interest in learning, improving the quality of teachers, and refining teaching materials and methods.
SCATTERING OF THE E-POLARIZED ELECTROMAGNETIC WAVE BY SOLITUDE CONDUCTIVE STRIP WITH IMPEDANCE
Authors: Vanin Viktor Antonovych , Koshovy George Ivanovych , Karpenko Valentyna Ivanivna , Vanin Borys Viktorovych
Published: September 2024

The key problem of scattering of a plane E - polarized electromagnetic wave by a solitude electrically conductive impedance strip is studied in detail. A well-posed full-wave mathematical model of scattering in the form of the first order singular integral equation was obtained by applying a modifica- tion of a classical method if integral equations. To examine this singular integral equation two basic methods were used. The first one is remarkable Lord Rayleigh’s asymptotic method, which delivers an explicit analytical solution in a narrow frequency range. It deals with the long-wave case of the plane E - polarized electromagnetic wave scattering problem. The second method is a direct numerical method, dealing with approximate computa- tion of definite integrals, which gives an approximate solution as well, but in the full-frequency range. A series of numerical experiments on scattering a E-polarized electromagnetic wave by impedance strip were carried out and are presented in this paper. Comparing of computation results shows good agreement in long-wave case of the plane E - polarized electromagnetic wave scattering problem, which indicates the correctness of numeric compu- tation in full frequency range as well.
NEW INFORMATION OPERATORS IN PROBLEMS OF NUMERICAL INTEGRATION OF FUNCTIONS OF THREE VARIABLES
Authors: Nechuiviter Olesia Petrivna , Ivanov Serhii Serhiyovych , Kovalchuk Kyrylo Gennadiyovych
Published: September 2024

Modern development of many technical areas is characterized by the rapid introduction of new digital technologies, algorithms, and methods which contribute to the emergence of latest approaches to obtaining, processing and analyzing information. It leads to further creation of new numerical methods for solving corresponding issues. Thereupon, there arises a problem of building new or improving known mathematical models, as well as their effective computer implementation. Depending on the modeling type the methods of probability theory and mathematical statistics, one- and mul- tidimensional interpolation and approximation theory are widely used in the process of preparing information. Along with the tasks of multidimen- sional interpolation, operators that restore intermediate values of quantities from an existing set of known data are widely used in the construction of mathematical models of various processes, in particular, when the values of a function of many variables on lines, planes, etc. are known. An example of the effective use of the above operators is the theory of calculating integrals of highly oscillating functions of many variables since the algorithm is chosen depending on the type of information about the functions. The author of this theory is the Laureate of the State Prize of Ukraine in Science and Technology, Doctor of Physical and Mathematical Sciences, Professor O.M. Lytvyn. The purpose of this article is to review the results of applying the theory of new information operators to the calculation of integrals of fast oscillating functions of many variables, as well as to present a new cubature formula for the approximate calculation of double integrals of fast oscillating functions of general type. The cubature formula is effective in terms of using the input information to achieve a given accuracy.
Digital Learning Media in Interactive Multimedia Based on Inquiry Approach for Sociology Learning in High Schools
Authors: Pinilih Yogi , Rejekiningsih Triana , Musadad Akhmad Arif
Published: September 2024

The rapid evolution of technology presents significant challenges in its integration into educational environments. Despite these challenges, interactive multimedia digital learning materials stand out as an effective means to meet educational objectives in high schools. By combining these materials with methodologies like inquiry-based learning, educators can offer a richer and more dynamic learning experience. Therefore, the objective of this research is to develop interactive multimedia with an inquiry-based approach that is suitable for use in education. The research method used in this study is research and development, adopting the Alessi & Trollip model. The research sample consist of 7 people which was media experts, subject matter experts, practitioners (subject teachers), and 42 students. Data collection is conducted through non-test methods such as observation and questionnaires. The research data is then analyzed qualitatively and quantitatively. The research results show that in the alpha testing phase, the developed interactive multimedia received a "Very Good" qualification from the experts and practitioners who acted as validators, with an overall average score of 87%. Meanwhile, the beta testing results with the research subjects, the students, gave a rating of 87% which falls under the "Very Good" qualification. Thus, interactive multimedia with an inquiry-based approach is deemed suitable for use as a learning medium in sociology subjects. This research showed that the inquiry-based multimedia for sociology could be a tool to facilitate learning activities in high schools.
The Relationship of Student Learning Discipline and Learning Outcomes in The Indonesian Language Subject Class V of Elementary School
Authors: Oktarian Pira , Amaliyah Nurrohmatul
Published: September 2024

This research aims to determine the relationship between learning discipline and Indonesian language learning outcomes for class V students at SD Negeri 1 Dendang. This research uses a quantitative approach with a correlation method. The sample was determined using a saturated sample technique or census with 39 students as respondents. Data collection techniques using questionnaires, documentation studies and interviews. To determine the level of relationship between learning discipline and learning outcomes, the Product Moment Correlation formula is used. From the calculation results, the rxy value is 0.923, which means it has a very strong relationship. The results of the hypothesis test obtained a significance value from the Coefficients table of 0.001 <0.05 and a t value of 14,565 > t table 2,026. through this test, it was concluded that learning discipline and Indonesian language learning outcomes had a positive and significant relationship so that hypothesis H1 was accepted, meaning that there was a relationship between student learning discipline and Indonesian language learning outcomes for class V SDN 1 Dendang.
Analysis of Educational Technology Approaches in Supporting Health Services at College Clinics
Authors: Undap Tiersa Reinie
Published: September 2024

Educational technology is a growing area of interest, including healthcare management in higher education. This study aims to evaluate the role of educational technology in improving health service management in college clinics, with a focus on the Universitas Negeri Manado Clinic. The research method used was a qualitative approach with data collection techniques including in-depth interviews, direct observation, and documentation. Data were analyzed using the triangulation method to identify key themes and in-depth interpretation of the influence of educational technology on health services. The results showed that the implementation of educational technology in college clinics can improve the efficiency and effectiveness of health services. Information technologies such as electronic medical record management systems and e-learning platforms have helped to improve the process of planning, implementing and evaluating health services. However, there are challenges in terms of system integration and additional training needs for staff. This study found that while educational technology provides significant benefits, its successful implementation is highly dependent on infrastructure readiness and user skills. Suggestions for improvement include increasing technology training for staff, updating hardware and software, and strengthening evaluation procedures to ensure that technology can be optimally used to improve the quality of health services.
The Effect of Teachers' Level of Self-Regulated Learning and Internet Self-Efficacy on Teaching Innovation in the Constructivist Curriculum
Authors: Budhi Santosa Eka , Sukmawati Fatma , Juwita Ratna , Prihatin Relly , Tri Cahyono Budi , Suparmi
Published: September 2024

In the era of modern education, innovation in teaching is a crucial aspect for improving learning quality. This study aims to find out the extent to which Internet Self-Efficacy (ISE) of teachers affects learning innovation in the constructivist curriculum and the extent to which Self-Regulated Learning (SRL) affects teachers in making learning innovations in the constructivist curriculum. The research method used is quantitative with a survey approach. Data was collected through a questionnaire filled out by 97 junior high school teachers in Central Java who implemented a constructivist curriculum. Based on the results of the regression analysis, it was found that in the condition that teachers have a high level of Internet self-efficacy, self-regulated learning (SRL) has a significant effect on the learning innovations that are carried out by teachers.  Another condition is the influence of SRL with low teacher ISE on teacher learning innovation. In the condition of low self-efficacy levels, SRL indicators of metacognitive skills, time management, and environmental settings did not have a significant effect on teachers' learning innovation. These findings indicate that teachers with high levels of self-regulated learning (SRL) and internet self-efficacy tend to be more innovative in implementing teaching methods that are in accordance with the principles of constructivism. The implications of this study emphasize the importance of developing teachers' self-regulated learning (SRL) and internet self-efficacy skills through continuous training and professional development programs to improve the quality of teaching in constructivist curricula.
Penerapan Pembelajaran Learning Cycle 5E Terhadap Penguasaan Konsep Mahasiswa Pada Materi Hukum Newton
Authors: Kholil Munawar , Arahman Emy
Published: September 2024

Tujuan dari penelitian ini adalah untuk mngetahui pengaruh pembelajaran Learning Cycle 5E terhadap penguasaan konsep fisika mahasiswa pada materi Hukum Newton. Penelitian ini merupakan penelitian kuasi eksperimen dengan desain two group pretest-posttes design. Teknik analisis data menggunakan uji independent sample t test, hasil uji independent sample t test untuk data pretest pada nilai sig (2-tailed) adalah 0,847 dan nilai ini lebih besar dari 0,05 artinyaÂ  kemampuan awal penguasaan konsep kelas eksperimen dan kelas kontrol tidak berbeda signifikan secara statistik. SedangkanÂ  hasil uji independent sample t test untuk data posttest nilai sig (2-tailed) adalah 0,000 dan nilai ini lebih kecil dari 0,05 artinya rata-rata kemampuan akhir penguasaan konsep kelas eksperimen (75,61)Â  dan kelas kontrol (64,61)Â  berbeda signifikan secara statistik dengan perbedaan rata-rata sebesar 11. hasil ini menunjukkan bahwa pembelajaranÂ  learning cycle 5E dapat dianggap sebagai metode pembelajaran yang efektif untuk meningkatkan penguasaan konsep mahasiswa pada materi Hukum Newton.
Pengembangan Media Pembelajaran Webtoon berbantuan Media Sosial Instagram Pada Materi Suhu dan Kalor Untuk Siswa SMP
Authors: Rini Dyah Umyek Bagus Timur , Kurniawati Maris , Aji Sudi Dul
Published: September 2024

Pengembangan media pembelajaran Instagram Webtoon berbantuan media sosial bertujuan untuk mengembangkan media pembelajaran yang efektif untuk meningkatkan kinerja belajar siswa. Sedangkan dari faktor kognitif diketahui bahwa tingginya tingkat penggunaan media sosial Instagram dan tingginya minat membaca cerita bergambar menunjukkan pengaruh minat belajar dan meningkatkan tingkat keberhasilan belajar. Fase define merupakan fase dimana siswa dianalisis melalui wawancara dan angket kebutuhan. Pendefinisian materi pembelajaran dan penyajian media pembelajaran berlangsung pada tahap desain. Pada tahap pengembangan, produk dievaluasi oleh ahli media, materi, dan bahasa, dan perbaikan dilakukan berdasarkan evaluasi ahli sebelum pengujian. Sampel uji berjumlah 53 siswa yang merupakan pengguna aktif media sosial dan pembelajaran penggunaan webtoon terkait suhu dan kalor di SMP Negeri 17 Malang dilakukan pada tahap diseminasi. Peningkatan kinerja siswa diukur dengan distribusi pretest dan posttest. Pada kategori â€œsedangâ€ peningkatan kinerja belajar siswa sebesar 0,60 dan pada kategori â€œsangat baikâ€ peningkatan kinerja sebesar 3,40. Berdasarkan hasil uji siswa dapat disimpulkan bahwa media pembelajaran webtoon berbantuan sosial Instagram efektif meningkatkan prestasi belajar siswa.
Peningkatan Motivasi dan Pemahaman Konsep Fisika SMP Melalui Penerapan Model Discovery Learning
Authors: Ain Nurul , Jufriadi Akhmad , Tiu Natalia
Published: September 2024

Penelitian ini bertujuan untuk mendeskripsikan peningkatan motivasi belajar dan pemahaman konsep dengan menerapkan model Discovery Learning. Subjek dalam peneltian ini adalah siswa kelas VIII SMPN 08 Poco Ranaka Kabupaten Manggarai Timur, Nusa Tenggara Timur, yang berjumlah 30 orang. Penelitian ini merupakan penelitian tidakan kelas (PTK) dengan menggunakan dua siklus. Materi pada penelitian ini adalah materi Usaha dan Pesawat sederhana pada materi Fisika SMP. Instrumen motivasi dikembangkan dalam bentuk observasi sedangkan instrumen pemahaman konsep dalam bentuk tes. Data dianalisis menggunakan tiga jalur kegitan yaitu redukasi data, penyajian data dan kesimpulan. Hasil penelitian menunjukan adanya peningkatan motivasi belajar dari siklus I ke siklus II, rata-rata sebesar 19,6%, sedangkan peningkatan dari kondisi awal tantang pemahaman konsep sebesar 15,5%. Hasil penelitian juga menunjukkan peningkatan siswa yang mencapai ketuntasan (KKM) dari kondisi awal 39,4% menjadi 88,2% pada siklus II. Kesimpulan penelitian ini adalah model discovery learning dapat meningkatkan motivasi belajaran dan pemahaman konsep siswa kelas VIII SMPN 08 Poco Ranaka.
Pengaruh Strategi Discovery Learning dan Gaya Kognitif terhadap Kemampuan Pemecahan Masalah dalam Pembelajaran Fisika
Authors: Sholikhan Sholikhan , Sayyadi Muhammad
Published: September 2024

Penelitian ini bertujuan untuk mengetahui :(1)perbedaan kemampuan pemecahan masalah antara penerapan pembelajaran discoveri dengan ekspositori (2). Perbedaan kemampuan pemecahan masalah antara siswa yang mempunyai kemampuan gaya kognitif field independent dengan field dependent. (3).Pengaruh interaksi  pembelajaran discoveri  dan gaya kognitif  terhadap kemampuan pemecahan masalah. Penelitian ini merupakan penelitian eksperimen semu yang melibatkan 120 siswa SMA, dengan rancangan percobaan analisis factor 2x2, dan rancangan penelitian pre test post test control group design. Ada  3 variable yang digunakan yaitu variable bebas strategi pembelajaran discoveri, dan variable terikat kemampuan pemecahan masalah, sedang gaya kognitif sebagai variable moderator. Data gaya kognitif diperoleh melalui angket, sedangkan data tentang kemampuan pemecahan masalah diperoleh melalui tes. Hasil penelitian menunjukan bahwa 1) ada perbedaan kemampuan pemecahan masalah, antara penerapan pembelajaran discoveri dengan ekspositori (2). Ada perbedaan kemampuan pemecahan masalah antara siswa yang mempunyai kemampuan gaya kognitif field independent dengan field dependent; 3) ada pengaruh interaksi  antara pembelajaran discoveri  dan gaya kognitif  terhadap kemampuan pemecahan masalah
Deoxidation of steel with calcium carbide. Influence of calcium carbide addition on steel contamination by non‑metallic inclusions
Authors: Shatovsky A. V. , Grudnitskiy O. M. , Konovalenko S. V. , Kovaleva I. A. , Kovalev A. A. , Morozov V. O.
Published: September 2024

One of the main factors determining the final properties of metal products is the quantity, morphology and distribution of non‑metallic inclusions in steel. The article deals with the issues related to the use of calcium carbide in steelmaking production, instead of secondary aluminum and other deoxidizing materials, in order to improve the quality of the products. During the experimental work on the use of calcium carbide in steelmaking production, instead of secondary aluminum and other deoxidizing materials, second grade calcium carbide according to GOST 1460–81 was used. To determine the contamination of steel with non‑metallic inclusions, sampling was carried out from hot‑rolled products obtained from continuously cast billets. According to the results, it was found that the improvement of melt deoxidation in melts using calcium carbide can be achieved by increasing its consumption. In turn, the use of calcium carbide for deoxidation of the melt upon its release from the electric arc furnace into the ladle, instead of secondary aluminum ingots of grade AB87 according to GOST 295–98, helps to reduce the contamination of steel with non‑metallic inclusions.
Radio‑absorbing composite materials and coatings based on aluminum and iron oxides for electromagnetic radiation shielding
Authors: Tumilovich M. V. , Peñalosa Ovalle D. I. , Boiprav O. V.
Published: September 2024

Radio‑absorbing composite materials, coatings and shields based on aluminum and iron oxides have been developed for protection of microwave devices from electromagnetic radiation (EMR). The patterns of changes in the characteristics of EMR reflection and transmission of electromagnetic shields based on the said powder‑like oxides have been established. It has been shown that the use of these composite materials for EMR shields can reduce the EMR reflection coefficient by 2–10 dB in the frequency range of 0.7–17.0 GHz and in the microwave range, and improve the operational properties of existing electromagnetic shields for the protection of electronic devices used for processing of limited distribution information, as well as in architectural electromagnetic shielding systems.

Keywords. Composite materials, electromagnetic radiation, elecomagnetic radiation shields, aluminum and iron oxides.
Features of water crystallization
Authors: Stetsenko V. Yu.
Published: September 2024

Water is mainly composed of ice nanocrystals. The peculiarities of water crystallization can be explained on the basis of its nanostructural structure and nanostructural crystallization. Atmospheric air molecules dissolve well in water and are adsorbed by its nanocrystals. It is shown that the amount of expansion of ice, when water solidifies, is proportional to the concentration of air dissolved in it. The concentration of air dissolved in water decreases significantly with an increase in its temperature. Hot water solidifies faster than cold water because there is less air concentration in hot water. Its bubbles, released on ice crystals, reduce the rate of crystallization of water. A large supercooling of water occurs as a result of the blocking action of adsorbed air, which prevents the unification of ice nanocrystals into crystallization centers. Shaking a bottle of supercooled water leads to desorption of air and accelerated crystallization of water. Air bubbles released on dendritic ice crystals reduce the degree of branching of these crystals. It has been shown that music increases the intensity of removal of gas bubbles and is able to influence the shape of dendritic ice crystals during water crystallization. It has been shown that an increase in the volume of sound and (or) a decrease in its frequency increase the intensity of removal of air bubbles from dendritic ice crystals and increase the branching of these crystals.
SISTEMA DE ENFRIAMIENTO EVAPORATIVO INDIRECTO FABRICADO CON IMPRESIÓN 3D Y RESINA CERÁMICA
Authors: Ruiz de Adana Santiago Manuel , Comino Francisco , Romero Pablo E. , Martinez José A. , Castillo-González Jesús , Navas-Martos Francisco J.
Published: September 2024

Los sistemas de enfriamiento evaporativo indirecto presentan una alternativa prometedora a los métodos convencionales de enfriamiento basados en compresión de vapor. Este estudio se centró en el diseño y la fabricación de un sistema de enfriamiento evaporativo de punto de rocío utilizando resina cerámica y la técnica de fabricación aditiva DLP (Digital Light Processing). A diferencia de los diseños tradicionales con canales rectangulares, este sistema emplea un diseño tubular. Se realizaron pruebas experimentales en condiciones de laboratorio, variando la temperatura del aire de entrada de 30 °C a 45 °C y el caudal de aire de 12 m³/h a 30 m³/h. Los resultados mostraron una significativa reducción de la temperatura del aire de hasta 20 °C y una alta eficiencia energética de enfriamiento (EER) de hasta 11, especialmente a la temperatura máxima de entrada y al caudal mínimo de aire. Estos hallazgos indican que los enfriadores evaporativos indirectos compactos pueden lograr un enfriamiento eficaz con bajo consumo de energía y un impacto ambiental reducido.
EVALUACIÓN TERMODINÁMICA DEL CICLO CLAUDE CON PREENFRIAMIENTO PARA LA LICUEFACCIÓN DE HIDRÓGENO
Authors: García López María Fernanda , Tenorio Rodríguez Fabián , Lugo Leyte Raúl , Torres Aldaco Alejandro , Lugo Méndez Helen Denise , Castro Hernández Sergio
Published: September 2024

En este trabajo se presenta la evaluación termodinámica del ciclo Claude con preenfriamiento para la licuefacción de hidrógeno, que se muestra en la Figura 1. En este ciclo, el hidrógeno es aspirado por el compresor a condiciones ambiente a 1 bar y 25°C de presión y temperatura respectivamente, y en la descarga del compresor se tiene una presión de 40 bar. Se parte del análisis energético, en donde se plantean los modelos matemáticos para determinar las propiedades como presión, temperatura, entalpía y entropía; con estas propiedades se obtienen los parámetros de desempeño como el trabajo de compresión, el trabajo de expansión, la fracción másica de hidrógeno licuado Z. Posteriormente, se realiza el análisis exergético con el fin de evaluar la producción de las irreversibilidades en el sistema. De los resultados obtenidos se muestra que, se requieren 12.85 kg de gas de hidrógeno para obtener 1 kg de hidrógeno líquido y el trabajo suministrado al compresor es de 6190.31 kJ/kg. Con la evaluación exergética se determina que, el ciclo produce una irreversibilidad por unidad de masa de 5549.38 kJ/kg. Por último, la eficiencia exergética del ciclo es del 14%.
A METHODOLOGY TO COMPARE REFRIGERANTS BASED ON THEIR THERMOPHYSICAL PROPERTIES
Authors: Navarro Peris Emilio , Alarcon David , Barcelo Francisco
Published: September 2024

To compare different refrigerants in a fair way has been always a matter of discusión. There are some properties like Isoentropic COP, volumetric capacities, pressure ratio that can be compared easily and supply some relevant information. However, how they are translated into real systems is not so direct. For instance, isentropic COP is obtained under the assumption that all the refrigerants are able to work in the same condensing and evaporating temperatures, but these variables depend on the temperature lift of the secondary fluid and in real systems, they will not be the same. The size of the heat exchangers and, hence, the cost depend on heat transfer coefficients and pressure drop, and extrapolating this data in a straightforward way is not easy; even the required refrigerant charge is not easy to determine.
In this work, the authors propose a methodology to compare different refrigerants based on the external operating conditions, the approach compares the system performance not only in terms of efficiency parameters but also in term of operation map, size and cost of the system and refrigerant charge. To do that, a basic modelling approach has been developed based on quite extended correlations for heat transfer coefficient, pressure drop and void fraction in the heat exchangers. The developed methodology does not pretend to be an exact design guide but a guide that researchers and students can use to estimate qualitatively the differences among refrigerants
EFECTOS DE LÁMINAS ACTIVAS DE PAPEL EN LA CALIDAD DE LOS TOMATES CHERRY DURANTE EL ALMACENAMIENTO EN FRÍO
Authors: Martínez Hernández Ginés Benito , Navarro Martínez Alejandra , López Gómez Antonio , Piñeros Castro Yineth Nubia
Published: September 2024

Los aceites esenciales vegetales (AE) tienen varias propiedades tecnológicas, como antimicrobianas, antioxidantes, inhibidoras de enzimas, etc., que luego son muy valoradas en el sector alimentario como alternativa de conservación sostenible a los controvertidos aditivos químicos. El envasado activo con AE es una técnica con gran potencial para alargar la vida útil de frutas y hortalizas. Para ello, estudiamos la aplicación de láminas de papel activo (kraft) (incluyendo complejos de inclusión de β-ciclodextrina con una mezcla de timol:eugenol (50:50)) para conservar tomates cherry (también conocidos como tomates uva) hasta 14 días a 10 ºC. La calidad del tomate se evaluó mediante análisis fisicoquímicos (sólidos solubles, acidez titulable y pH), de firmeza, de color y microbianos. El crecimiento microbiano de psicrófilos, mesófilos y mohos estuvo muy controlado, con recuentos ≈1 unidad logarítmica más bajos en comparación con el control tras 14 días de almacenamiento refrigerado, en los tomates en los que se utilizaron las láminas activas. Además, también se controló el crecimiento de enterobacterias y levaduras, con recuentos hasta 0,6 unidades logarítmicas inferiores tras 14 días de almacenamiento refrigerado. Además, las láminas activas no afectaron (p>0,05) a la calidad fisicoquímica (sólidos solubles, acidez titulable y pH), la firmeza o el color de los tomates. En conclusión, el envasado en láminas activas de AE controló el crecimiento microbiano durante el almacenamiento refrigerado de los tomates.
VIABILIDAD TÉCNICO-ECONÓMICA DE DISTINTAS TECNOLOGÍAS DE RECUPERACIÓN DE CALOR EN LA INDUSTRIA AGROALIMENTARIA
Authors: Hassan Abdelrahman H. , Payá Herrero Jorge , Gómez-Elegido Daniel , Lucás-Alós Pablo , Sanjuan Víctor
Published: September 2024

El presente trabajo consiste en un estudio técnico-económico para analizar la aplicación potencial de distintas tecnologías de recuperación de calor en ARYZTA, de la industria agro-alimentaria. En concreto, se ha estudiado la posibilidad de producir vapor saturado a 150 °C mediante el uso de una bomba de calor de alta temperatura. De esta manera, se reduciría el consumo de las resistencias eléctricas actuales. El trabajo está enmarcado dentro del contexto del proyecto europeo PUSH2HEAT del programa H2020. Los resultados indican que la integración de una bomba de calor de alta temperatura reduciría las emisiones de CO₂ en un 61%, con un periodo de retorno inferior a un año. Por tanto, se trata de una alternativa a considerar en la planificación energética de la empresa dado su beneficio potencial y el impacto que puede tener para descarbonizar la industria.
APLICACIÓN DE LA METODOLOGÍA SRI PARA LA EVALUACIÓN DEL FUNCIONAMIENTO DE LAS INSTALACIONES TÉCNICAS DEL EDIFICIO
Authors: Aguilar Valero Francisco Javier , Martínez Pedro J. , Lucas Manuel , Martínez Pedro , Ruiz Javier , Crespí Damián , Lucas Roberto , Vicente Pedro G.
Published: September 2024

En 2018, la Directiva Europea de Eficiencia Energética en Edificios (EPBD 2018/844) propuso a los Estados miembros el uso de un nuevo indicador de Eficiencia Energética directamente relacionado con el nivel de inteligencia de los edificios, denominado SRI (Smart Readiness Indicator). La metodología SRI evalúa la capacidad de un edificio para actuar de forma autónoma sobre las instalaciones técnicas de este (calefacción, refrigeración, iluminación, etc.) para mejorar su eficiencia energética, adaptando el funcionamiento a las necesidades de sus ocupantes y de la red eléctrica. El estudio llevado a cabo por miembros del grupo de investigación de ingeniería energética sobre 18 edificios públicos de la provincia de Alicante pone de manifiesto que, en términos generales, el nivel de preparación inteligente de los edificios analizados es bajo, registrando índices SRI de entre el 7% y el 49%, con una calificación de entre G y E. Asimismo, como parte del trabajo realizado en este estudio se han propuesto diversas estrategias de mejora con las que se pretende optimizar el funcionamiento de las instalaciones técnicas. Tras la aplicación de las mejoras, se estima que el nivel SRI de los edificios podría alcanzar un valor promedio del 43% (Calificación E)
Characterization of Variably Protease-Sensitive Prionopathy by Capillary Electrophoresis
Authors: Myskiw Jennifer , Bailey-Elkin Ben A , Avery Kristen , Barria Marcelo A , Ritchie Diane L , Cohen Mark L , Appleby Brian S , Booth Stephanie A
Published: September 2024

Variably Protease Sensitive Prionopathy (VPSPr) is a rare human prion disease that, like Creutzfeldt-Jakob disease (CJD), results in the deposition of abnormally folded prion protein aggregates in the brain and ultimate fatality. Neuropathology and clinical features of VPSPr are heterogeneous. However, the key discriminating feature is the relative sensitivity of the pathological prion protein to proteinase digestion compared to that typically seen in other human prion cases. Three major fragments of 23, 17 and 7 kDa are characteristic of the disease following digestion with proteinase K. We recently reported the utility of the highly adaptive and reproducible ProteinSimple™ capillary electrophoresis (CE) system to perform protein separation of PK digested prion protein in CJD. Consequently, we explored capillary-based electrophoresis (CE) technology as a sensitive method to detect and characterize VPSPr in a cohort of 29 cases. The unique 7 kDa fragment has high intensity, particularly in cases with the codon 129 VV genotype, but can be missed by regular Western blotting due to the small size. However, this fragment is readily detected by CE in all cases. In addition, the flexibility of CE produced highly reproducible, semi-quantitative data for determining relative proteinase K sensitivity and epitope mapping of representative cases from each codon 129 genotype (VV, MV and MM).
Metabolomics Analysis Reveals Potential Biomarkers for Diffuse Axonal Injury
Authors: Chen Weiliang , Wang Guanjun , Wu Jiayi , Li Shengwen , Yao Chunyu , Su Wen , Xu Lisheng
Published: September 2024

Background
Metabolism is essential for life maintenance, neurological function and injury repair, yet its role in diffuse axonal injury (DAI) is not fully understood.
Methods
30 DAI patients and 34 non-DAI patients were recruited based on the classification criteria using Magnetic Resonance Imaging (MRI) within 30 days of admission in this exploratory research. Serum samples and clinical parameters were collected upon admission, with the Glasgow Outcome Scale Extended (GOSE) at 6 months post-injury used as the neurological functional outcome. The metabolome was assayed using liquid chromatography-mass spectrometry.
Results
The DAI group and non-DAI group showed significant differences in pupillary light reflex, Glasgow Coma Scale (GCS) score, and Marshall computed tomography (CT) score, as well as in the expression levels of 27 metabolites in serum. Random forest analysis indicated that Lysophosphatidylcholine (LPC) 22:3 sn-2 and carnitine C8:1 greatly contributed to distinguishing DAI patients from non-DAI patients (MeanDecreaseGini: 3.81, 5.16). The combined prediction of DAI using these two metabolites yielded an area under the curve (AUC) of 0.944, which was higher than the combination of clinical parameters.
Conclusions
The serum metabolomics revealed potential biomarkers for DAI and has significant value for exploring pathogenesis, determining early diagnosis, and improving long-term neurological function.
From intervention studies to national programs, what are the favoring and hindering factors? A scoping review
Authors: Rola Renata Cristina Ferreira , Ramirez Tatiana Rivera , Kroeger Axel
Published: September 2024

Background
The translation of successful health projects into public health practice is among the most relevant challenges to pursue better health results, including the outcomes established by the United Nations sustainable development goals (SDGs). Healthcare interventions proven cost-effective should be expanded into broader policies and practices. This process is called scaling-up and its success depends on several factors. To critically think about how to scale-up projects or adapt programs, it is necessary to identify potential barriers and facilitators. In this sense, this study aims to document the type of public health programs which have been scaled up, describe the favoring and hindering factors of this process, and critically analyze the findings about it.
Methods
To reach this goal, this project used the scoping review method to synthesize the knowledge of a certain theme through available publications. The databases used in this review were PubMed, Web of Science, Cochrane Library, Scopus, VHL, Scielo, and Google Scholar.
Results
Through the selection process from a total of 7,027 search hints, 30 relevant papers were included. The found factors that impacted the scaling-up process were organized based on categories of the ExpandNet/WHO framework. The results indicate that poor "user organization", "institutional environment" and "resource mobilization" were the most frequently mentioned hindering factors for scaling-up processes. Favoring factors included strong leadership, well defined roles, good coordination, positive political environment and community support and engagement.
Conclusion
Hindering and favoring factors do not exist in isolation, but are correlated, interact, enhance or hinder one another. Beyond the practical advice given in this paper, further research recommended that investigates the association between different factors.
Factors associated with male recruitment in a multi-site randomized behavioral clinical trial targeting the metabolic syndrome: analysis of screening and recruitment data from the ELM trial
Authors: Suzuki Sumihiro , Yeh Chen , Crane Melissa M. , Daniels Bryce , Lohse Barbara , Karavolos Kelly , Olinger Tami , Nicklas Jacinda , Powell Lynda H.
Published: September 2024

Background
Males are underrepresented in behavioral clinical trials of lifestyle change or weight loss. Little is known about factors that facilitate or deter males from participating in such trials. The aim of this exploratory study was to describe the sample of males recruited into a multi-site behavioral trial targeting lifestyle change and remission of the metabolic syndrome and to investigate factors associated with trial interest at different stages of recruitment and overall. Similar analyses were performed for female participation to investigate the uniqueness or consistency with the findings for males.
Methods
Data collected at various stages of recruitment in an ongoing multi-site behavioral clinical trial were used. A series of logistic regressions compared respondents who moved forward to the next step of the screening process versus those who did not. These analyses were stratified by sex. A chi-squared test was used to directly compare proportions of men and women who chose to advance to the next step.
Results
Males who showed interest in the trial were more likely to be self-aware of their current health risk. Comparison of males and females showed that men tended to lose interest earlier in the recruitment process (58.3% of men vs. 66.5% of women attended an in-person information session, p < 0.001), but the proportion that moved forward among those who demonstrated initial interest was similar in men and women.
Conclusion
Efforts to increase male enrollment in behavioral clinical trials will benefit from a focus on early stages of recruitment, aiming to increase potential participants’ initial levels of interest and awareness of their health risk. As men and women differ in the reasons they choose to participate in a behavioral trial, recruitment should be tailored to sex to maximize trial participation.
Trial registration
ClinicalTrials.gov number, NCT04036006, https//clinicaltrials.gov/study/NCT04036006
Genome-wide Mendelian randomization and single-cell RNA sequencing analyses identify the causal effects of glucocorticoids on inflammatory disorders of breast
Authors: Chen Shuran , Xue Lei , Li Lixiang , Yin Zhenglang , Yang Wencan
Published: September 2024

Background
Inflammatory disorders of breast(IDB) is a common reason for glucocorticoids(GCs) treatment in women. However, there are no studies elucidating the relationship between GCs and the risk of IDB in general population. Therefore, we employed Mendelian randomization (MR) to explore the causal associations between GCs and IDB.
Methods
A two-sample MR analysis was performed using the summary statistics sourced from the largest genome-wide association studies(GWAS) conducted in GCs, glucocorticoid receptor-related mRNAs(GRs) and IDB. Inverse-variance weighting (IVW), MR‒Egger, and weighted median (WM) were further supported by several sensitivity analyses. Metascape and Single-cell RNA sequencing(scRNA-Seq) were used to analyze the functions and distribution of GRs.
Results
We detected causal genetic associations between GCS and IDB (OR, 1.22 (95% CI, 1.019– 1.462), P = 0.021). Further WM measure (OR, 1.294 (95% CI, 1.002– 1.671), P = 0.048) also showed similar results. No causal association was found between GCs and Childbirth-Associated Breast Infections. ScRNA-Seq confirmed that GRs were expressed in almost all immune cells, but more highly expressed in macrophages. The expression quantitative trait locus (eQTL) data suggest that NR1I3 is a high-risk factor for IDB.
Conclusions
We are the first to use MR analysis to explore the causal relationships between GCs and IDB, revealing an increased risk of IDB with GCs. These may caused by the highly expressed GRs on macrophages in breast tissue.
Therapeutic and Analgesic Efficacy of Photobiomodulation Therapy (PBMT) in the Management of Trigeminal Neuralgia: A Case Report
Authors: Al-Kufi Hani M. , Alhumadi Almustafa , Ali Marwah S. , Al-Deen Dhyaa M.J. Hirz
Published: September 2024

Purpose: The aim of this study is to evaluate the therapeutic and analgesic effect of PBMT in management of trigeminal neuralgia.
Methods: A 42-year-old female patient was chosen for this study. She experienced severe, unilateral, electrical-like pain episodes originating from specific points on the right side of her face, including the zygomatic region, infraorbital area, lateral side of the nose, and the upper right portion of the upper lip. The pain episodes were typically triggered by specific activities, such as speaking or washing her face. The procedure utilized photobiomodulation therapy with an EPIC X 940 nm diode laser. The laser settings included: power density of 0.5 W/cm², continuous wave (CW) emission mode, laser beam diameter on the target area of 3 cm, spot size of 7.065 cm², and an exposure time of 30 seconds for each trigger point. Treatment sessions were conducted three times per week, with a total of 12 sessions. As for the points of application, Laser irradiation was administered to each trigger area along the course of the maxillary branch of the trigeminal nerve.
Results: The results obtained from the study show a significant reduction in VAS after 12 sessions and after a period of 6 and 12 months postoperatively following PBMT.
Conclusions: According to the results obtained from the study, PBMT was effective in reducing pain in patients with idiopathic TN and can be considered an adjunctive method to pharmacotherapy, offering more satisfactory results without adverse effects. To achieve the maximum therapeutic effect using PBMT, correct diagnosis and proper knowledge of laser-tissue interaction are essential.
Exon 1 Methylation Status of CDH13 is Associated with Decreased Overall Survival and Distant Metastasis in Patients with Postoperative Colorectal Cancer
Authors: Xiang PengCheng , Li PengJu , Yuan Xiaoqi , Zhao Xiuhao , Xiao Zitian , Chen Bingguan , Biskup Ewelina , Han Junyi
Published: September 2024

Background
Cadherin 13 (CDH13) is a member of the cadherin superfamily that exerts tumor-suppressive effects on cancers derived from epithelial cells. Although hypermethylation of CDH13 promoter has been reported in various cancers, its prognostic value for colorectal cancer (CRC) is still controversial. The methylation alterations of CDH13 within exon 1 have not yet been investigated.
Methods
A total of 49 CRC patients were recruited for the prospective study. The methylation status of CpG sites was quantified by Bisulfite Amplicon Sequencing (BSAS) in malignant tissues and adjacent non-malignant tissues. The primary endpoint of the study was overall survival (OS) after surgery. The relationship between methylation level with pathological stage and OS was also evaluated.
Results
Compared with adjacent tissues, the overall average methylation level within exon 1 was significantly increased in tumor tissues (p < 0.001). The association study showed that the hypermethylation status of the CpG1 site was non-significantly associated with the presence of distant metastasis (p = 0.032). Moreover, the hypermethylation of two CpG sites, including CpG1 (p = 0.003) and CpG5 (p = 0.032), was associated with worse OS in CRC. Co-hypermethylation of CpG1 and CpG5 sites was significantly associated with a worse clinical outcome (HR: 4.43 [95% CI:1.27–15.46]; p = 0.019) in multivariate Cox regression analysis.
Conclusion
The methylation level of CDH13 exon 1 in CRC tissue was significantly higher than in adjacent non-malignant tissues. Hypermethylation at the CpG1 site suggests a risk of distant metastasis in CRC. The hypermethylation of the CpG1 site and CpG5 site, including the co-hypermethylation of these two sites, may serve as a valuable prognostic biomarker.