bluuebunny/crossref_metadata_2025 huggingface dataset:
Fenomena Mengabaikan Keadilan dalam Penegakan Hukum
Authors: Suhardin Yohanes
Published: August 2023

Happening phenomenon in law enforcement at current Indonesia is while justice progressively most moves over. Justice tend is ignored in law enforcement, eventually justice is fundamental and realities of laws. Even frequent being said justice is its heart of law, therefore while in law enforcement justice be ignored, law becomes not wherewith. Justice institute as institute foremost and castled deep enforcement episodic law functions as institute of place law to be kidded, commercialized and even commercial it’s called with jurisdiction mafia. That jurisdiction mafia takes shelter at turns back rule of law. To rule of law, justice and utility is sacrified. Apparatus enforcer law just focussed on legal security aspect without tries to respond society justice charge that wants that deep law enforcement to be done by that progressive ala close to justice point in society. It visually of justice verdict those are assessed soft especially in impacted corruption matter negative to realize it national aim which is society which fairs and affluent.
TINJAUAN YURIDIS MENGENAI PERDAGANGAN ORANG DARI PERSPEKTIF HAK ASASI MANUSIA
Authors: Suhardin Yohanes
Published: August 2023

Indonesia have regulated the trafficking since the Criminal Code (KUHP) era, the Act 39 of 1999 concerning Human Rights, the Act 23 of 2002 about Protection Child until currently we have the Act 21 of 2007 concerning Trafficking in Persons. However, the trafficking in persons cases increase dramatically and the law enforcement of trafficiking in persons was not function well. There are caused by some factors such as: the lack of sanction, the lack awareness of society, lack socialization of Trafficking in persons, and lack of victim awareness reporting the trafficking in person’s case to the police. From the social perspetive, the poor condition of the victim also become crusial factor caused weak of the law enforcement of trafficking in persons. Trafficking in persons in reality is not only breaking the Act 21 of 2007 and others trafficking in persons regulation but also tend to against the principle humiliated standard and human dignity and against of the human rights.
PENYELESAIAN SENGKETA BISNIS MELALUI ONLINE DISPUTE RESOLUTION DAN PEMBERLAKUANNYA DI INDONESIA
Authors: Sutiyoso Bambang
Published: August 2023

This paper is an attempt to discuss some issues concerning of business settlement via Online Dispute Resolution (ODR), Online Arbitrate Agreement, Online Arbitrate Procedure, Online Arbitrate Judgment, and examining the practice of the ODR in Indonesia. This description is an attempt to give comprehensive view about ODR and how the law will be used to mediate the civil dispute using the Internet media and alternative possibility resolve civil conflict in the Indonesian society. In the future, this discussion will open a new way in facilitating Indonesian people, especially that are seeking the justice provision, in the resolving their dispute using via the ODR.
PENGAMBILAN FOTO COPI MINUTA AKTA DAN PEMANGGILAN NOTARIS
Authors: Sukisno Djoko
Published: August 2023

The main problem of this paper is what can be used as limitation of Majelis Pengawas Daerah Notaris in implementing Article 66 Regulation Number 30 in the year of 2004 about Notaris Position especially in civil court ? The conclusion of this paper is the answer of the problem. The agreement given to the judge to take photocopy of the deed if there is not copy of the deed of there is a doubt toward the copy of the deed, and the agreement to call Notary by the judge can be given if it is related to official certificate ; the material of the certificate still needs witness form Notary as expert witness or Notary plays as the defender.
Sexual dimorphism in wing pigmentation promotes rapid species diversification in Zygoptera but not Anisoptera
Authors: Padilla-Morales Benjamin , Davis Katie , Barnes Chloe , Muñoz Aldo Carillo , García-Miranda Oscar , Castillo-Morales Daniel , Barragán Gustavo Wapper , López Andrea Nieto , Kilili Huseyin , Delmer Cyrille , Serrano-Meneses Martin , Wills Matthew , Urrutia Araxi
Published: August 2023

Sexual selection has long been thought to promote speciation, but
evidence is inconclusive. In Odonata - which includes dragonflies and
damselflies-, wing pigmentation has been found to be influenced by
sexual selection. Past evidence shows that wing pigmentation in males is
a driver of speciation in damselflies. However, whether sexual
dimorphism per se is associated with species diversification rates has
not been tested. Here we test whether wing pigmentation sexual
dimorphism influences diversification rates in a supertree of 1,239
species, the most comprehensive phylogeny inferred for the group. We
find that wing pigmentation among dimorphic males is associated with
higher species diversification rates in damselflies but not in
dragonflies.  This study presents the first evidence of the role of
species sexual dimorphism in species diversification in a clade
identified as a marker of habitat quality. In the face of accelerating
biodiversity loss, uncovering diversification drivers is of pressing
importance.
Robust cellular immune responses to BNT162b2 SARS-CoV-2 mRNA vaccine in T2DM individuals in Bangladesh
Authors: Shahriar Habib , Farzana Islam , Tahmina Akther , Afzalun Nessa
Published: August 2023

Introduction: Diabetes being one of the most common
comorbidities of COVID-19, is prioritized for SARS-CoV-2 vaccination. To
evaluate the T-cell mediated immune responses in T2DM, this study
assessed and compared IFN-γ and IL-2 secreting PBMCs
against the SARS-CoV-2 BNT162b2 mRNA vaccine. Methods: 19 known
cases of type 2 diabetes and 16 healthy controls were included through
purposive sampling and were regularly sampled before
1 dose, after 1 and
2 dose of vaccination. Ex-vivo ELISpot assays for
IFN-γ and IL-2 were done using isolated PBMCs along
with HbA1c status and SARS-CoV-2 spike-specific IgG antibody.
A p-value < 0.05 was considered
significant. Results: All participants were seroconverted after
1 dose and showed a robust rise of
IFN-γ and IL-2 secreting PBMCs counts in T2DM
participants irrespective of hypertension, gender and age after 2 doses
of vaccination. However, IFN-γ secreting PBMCs counts
were significantly lower in type 2 diabetic group than healthy control
group after 1 dose. Conclusion: Although
type 2 diabetic participants had a lower response initially, BNT162b2
mRNA vaccine overall induces a robust T-cell mediated immune response
Integrative perspective on pathophysiology of Schizophrenia and its management through African traditional medicinal plants
Authors: Balkrishna Acharya , Singh Sumit , Verma Sonam , Bora Pratha , Dobhal Vidhi , Arya Vedpriya
Published: August 2023

The majority of physiologic activities in the brain and associated
illnesses include multiple neurotransmitter systems and their
dysfunctional consequences, which entails elucidation of the interaction
among distinct pathways. In light of recent revaluations in
schizophrenia research, this review focuses on the interplay between
dysregulations of neurotransmitter systems, including the effects of
systemic neuroinflammation and a disruption of Wnt-pathways. This
includes a detailed network-circuit illustration centered on
dysregulated glutamatergic transmission and NMDA receptor hypofunction
explaining the role of dopamine and glutamate, their receptors like D2R,
NMDAR, AMPAR, and their agonist/co-agonist, antagonist, along with a
synergism of downstream effector molecules like Akt/GSK-3,
Wnt/β-catenin, Cytokines, CRP, NF-κB, while simultaneously illuminating
involvement of inflammatory, oxidative, and Kyunurenic mechanisms, and
their implications towards the progression of schizophrenia. We are for
the first time producing a comprehensive list of associated biomarkers
with their key roles and features. Schizophrenia is becoming more
prevalent in African countries, and existing antipsychotic therapeutic
regime provides little assistance, other from being inaccessible,
ineffective, and laden with complications. It is critical to focus on
traditional knowledge; thus, in the second section, we present a
detailed list of 27 African plant species across 23 families, replete
with phytocomponents proven effective in in-vivo models and their likely
mechanism of action. In essence, the first section of the review
presents the underlying mechanism of schizophrenia development via an
interactive signaling pathways approach and a list of identified
biomarker components, while the second section presents a comprehensive
list of African ethnomedicinal plants used in disease management.
A Comparative Analysis of Unit Fragility and the Relative Risk Index
Authors: Heston Thomas F
Published: August 2023

BACKGROUND: In biostatistics, evaluating fragility is crucial for
understanding their vulnerability to miscategorization. One proposed
measure of statistical fragility is the unit fragility index (UFI),
which measures the susceptibility of the p-value to flip significance
with minor changes in outcomes. Although the UFI provides valuable
information, it relies on p-values, which are arbitrary measures of
statistical significance. Alternative measures, such as the fragility
quotient (FQ) and the percent fragility index, have been proposed to
decrease the UFI’s reliance on sample size. However, these approaches
still rely on p-values and thus depend on an arbitrary cutoff of p
< 0.05. Instead of quantifying fragility by relying on
p-values, this study evaluated the effect of small changes on relative
risk. METHODS: Random 2x2 contingency tables associated with an initial
p-value of 0.001 to 0.05 were evaluated. Each table’s UFI and relative
risk index (RRI) were calculated. A derivative of the RRI, the percent
RRI, was also calculated along with the FQ. The UFI, FQ, RRI, pRRI,
initial p-value, and sample size were compared. RESULTS: A total of
15000 cases were tested. The correlation between the UFI and the p-value
was the strongest (r = -0.807), and the correlation between the pRRI was
the weakest (r = -0.395). The RRI had the strongest correlation with the
sample size (r = 0.826), and the UFI had the weakest correlation (r =
0.3904). The coefficient of variation for the average RRI was the
smallest at 28.3%, and for the FQ, it was the greatest at 57.0%. The
correlation between the UFI, FQ, and p-value is significantly greater
than the correlation between the RRI, pRRI, and p-value (for all
comparisons, p < 0.001). CONCLUSION: The RRI and pRRI are
significantly less correlated with the p-value than the UFI and FQ,
indicating relative independence of the RRI and pRRI from p-values.
Pancreatic panniculitis associated with periampullary duodenal diverticulum
Authors: Tirnanic Tanja , Radevic Tatjana , Djordjevic Andrea , Petrov Nenad , Mijuskovic Zeljko
Published: August 2023

Introduction. Pancreatic panniculitis (PP) is a rare type of lobular panniculitis that manifests as painful erythematous nodules on the skin of the lower extremities. Subcutaneous fat necrosis caused by the release of pancreatic enzymes is the underlying cause of the disease, affecting around 2?3% of patients with pancreatic diseases. Case report. We present a case of a 58-year-old male patient who was admitted to our clinic due to the appearance of painful erythematous nodules on the lower extremities and trunk. Laboratory results revealed increased levels of pancreatic enzymes, amylase, and lipase, as well as heightened levels of glucose and inflammation markers. The histological analysis of the skin lesion biopsy revealed the presence of predominantly lobular panniculitis in the hypodermis, with areas of fatty tissue necrosis/saponification and remnants of adipocytes (?ghost cells?). Abdominal computed tomography scan demonstrated peri-ampullary diverticulum (PD) of the duodenum, with no signs of pancreatitis or other pancreatic abnormalities. Esophagogastroduodenoscopy showed a wide opening of PD in the D2 segment of the duodenum. The patient was successfully treated with pancreatin therapy, resulting in a significant reduction of skin lesions and decreased levels of pancreatic enzymes. Conclusion. Duodenal PDs can be the cause of PP, most likely due to the pressure they exert on the pancreatic duct, which can lead to elevated values of pancreatic enzymes. Depending on the individual characteristics of the patient, symptomatic duodenal PD may be treated with operative or non-operative measures. Treatment of PP primarily involves addressing any underlying medical condition.
RFID-based logistics big data asset evaluation and data mining research
Authors: Li Yufeng , Mu Dan , Li Jingbo
Published: August 2023

With the rapid rise of e-commerce platforms, in view of the sharp increase in the amount of data in the logistics system, the timely update and processing of relevant logistics information data have assumed a particular relevance. In this paper, we fully draw on the excellent performance of radio frequency identification (RFID) technology and data mining technology, begin by using RFID technology to authenticate logistics commodities, move on to extracting relevant feature information and finally carry out a detailed comparison between k-nearest neighbour algorithm, support vector machine (SVM) algorithm, logistic regression (LR) algorithm and improved LR algorithm. The algorithm provides a solution method for asset information collection channel and data mining classification algorithm. It meets the needs of different customers, and provides a variety of working modes, which helps to improve the time and operation efficiency of data processing algorithms. The results show that the SVM algorithm only achieves 93.8% accuracy when iterating 50 times for the classification results of the classification samples containing the objective functions ofx1andx2. The improved LR algorithm stochastic gradient descent algorithm has a classification accuracy of 94.6% after 50 iterations. The RFID-based logistics big data asset evaluation and data mining research identification algorithm has obvious advantages, and the accuracy rate reaches 97.3%.
Comparison of infrazygomatic crest bone screw position using a postero-anterior cephalogram versus cone-beam computed tomography: a cross sectional study
Authors: Ashfaq Sauni , Mathew Silju , Prashantha G.S. , Sabrish Sharanya , Krishnamurthy Sathyashree , Bhaduri Nirajita
Published: August 2023

Background

The position of infrazygomatic crest bone screws is an important consideration in determining the success of orthodontic treatment. The aim of this study was to compare the position of infrazygomatic crest (IZC) bone screws in relation to skeletal and dental parameters using postero-anterior (PA) cephalograms and cone beam computed tomography (CBCT).

Methods

A CBCT scan and a PA cephalogram were taken of 19 patients (8 males; 11 females) after IZC bone screw placement. Each CBCT image was reconstructed and oriented using the CS 3D CBCT software (Carestream Dental LLC, Atlanta, USA) and was subsequently analysed. The landmarks were traced on the PA cephalogram. The angulation of the IZC bone screw was measured with respect to three skeletal and two dental landmarks and compared between the two imaging modalities. A paired t-test was applied to compare the means of different variables between the PA cephalogram and CBCT scan.

Results

The results showed no statistically significant difference between the two imaging modalities with respect to four landmarks, i.e., the inter-jugale plane, the mid sagittal plane, the zygomatic arch and the perpendicular long axis to the 1st molar but a small statistically significant difference was seen with respect to measurements from the facial surface of the 1st molar (P ≤ 0.05).

Conclusion

The angulation and position of an IZC bone screw are consistent between the two imaging modalities. A PA cephalogram may be used as a substitute for a CBCT scan to reduce the radiation exposure to patients.
Recycling of foundry sand wastes in self-compacting concretes: Use as cementitious materials and fine aggregates
Authors: Sebki Ghania , Mechakra Hamza , Saidi Mohammed , Safi Brahim
Published: August 2023

This paper discusses waste recycling as a compound in building materials. Foundry sand-based self-compacting concretes (SCC) were investigated to see the possibility of recycling foundry sand wastes (FSW). FSW was used as a cementitious addition (by partial cement replacement: 10%, 20% and 30% wt. cement), then as a fine aggregate (by partial sand substitution: 10%, 30% and 50% wt. sand). For this, an experimental study was carried out to evaluate physical and mechanical properties of SCC at fresh and hardened states. The results show that the FSW also played the role of a filling material, which slightly improved the compactness of the concrete while saving part of the cement. According to the results of the non-destructive tests by ultrasonic tests, all concretes gave a dynamic modulus of elasticity that was almost identical and which was greater than 36 GPa. Compressive strength value slightly reduced with the cement substitution by the crushed foundry sand waste. However, up to 30% FSW, the compressive strength recorded after 28 days was around 30 MPa. A slight decrease in the fluidity of concrete at 10% substitution of natural sand by FSW was observed. After up to 30% replacement of sand by foundry sand wastes, the fluidity of the concrete was improved. The improvement in the fluidity of the concretes was perhaps due to the fineness of the natural sand and that of the foundry sand. When used as up to 50% of sand substitution, FSW can be used as a fine aggregate for concretes without affecting the essential proprieties of concretes.
Synthesis of functionalized 4,5-dihydroisoxazoles decorated with the dimethylphosphinoyl group
Authors: Fedyk Andrii V. , Chalyk Bohdan A.
Published: August 2023

Aim. To synthesize a hybrid molecular platform incorporating dimethylphosphinoyl and 4,5-dihydroisoxazole moieties suitable for the creation of focused combinatorial libraries of compounds.Results and discussion. The base-promoted interaction of halogenoxides with dimethyl(vinyl)phosphine oxide under mild conditions allowed us to obtain 11 isoxazoline–dimethylphosphine oxide hybrids in moderate yields. The reaction was found to be regio- though non-stereoselective. Furoxans were identified as possible side products of the reaction.Experimental part. The one-pot interaction with dimethyl(vinyl)phosphine oxide was used for the synthesis of the target compounds. Nitrile oxides were obtained in situ from the corresponding halogenoximes by base-promoted generation. The ADME parameters for a synthesized 5-P(O)Me2-isoxazoline compared to its isosters with the same core structure were predicted using a SwissADME Web Tool. The compounds obtained were characterized by 1H, 13C, 19F, 31P NMR spectroscopy and HPLC-MS spectrometry methods, as well as the elemental analysis.Conclusions. A practical approach to the isoxazoline platform decorated with a 5-P(O)Me2 “magic” group and containing 3-substituent with an easy-to-modify functionality has been developed. On example of the piperidine derivative, the effect of the dimethylphosphinoyl group on physicochemical properties and ADME parameters compared to its isosters has been determined.
Spaceflight Logistics Approach to Modeling Aggregated Vehicle Concepts
Authors: Downs Chloe , Prasad Akshay , Robertson Bradford , Mavris Dimitri N.
Published: August 2023

As space exploration moves toward long-duration, sustainable campaigns, operations such as in-space rendezvous, multiple launches, and in-space rendezvous or In-Situ Resource Utilization plants complicate campaign planning. The field of spaceflight logistics has been developed to perform the logistical planning for these new campaigns in an automated manner. Though previous tools have included aggregated vehicle concepts consisting of multiple vehicles, they have key limitations that may not be able to assess campaigns with more complex vehicle architectures and mission operations. This works aims to address these limitations by formulating a method to include independently operating vehicles that can also operate as an element within a larger stack across various different mission segments. Because of the use of the path-arc formulation, the optimizer has the flexibility to decide to use the independent vehicle stages independently, or within a stack. To prove the usefulness of this formulation, the methodology will be applied to a sample case that uses some of these aggregated space vehicles. In particular, a case study of a government reference Human Landing System mission will be used due to its inclusion of aggregated space vehicles.
Data-Driven Departure Flight Time Prediction Based on Feature Construction and Ensemble Learning
Authors: Xu Jiaxin , Zhang Junfeng , Peng Zihan , Bao Jie , Wang Bin
Published: August 2023

Temporal–spatial resource optimization within the terminal maneuvering area has become an important research direction to meet the growing demand for air traffic. Accurate departure flight time prediction from taking off to the metering fixes is critical for departure management, connecting the surface operations, and overhead stream insertion. This paper employs ensemble learning methods (including bagging, boosting, and stacking) to predict departure flight times via different metering fixes based on four feature categories: initial states, operating situation, traffic demand, and wind velocity. The stacking method employs a linear regressor, a support vector regressor, and a tree-based ensemble regressor as base learners. The Guangzhou Baiyun International Airport case study shows that the stacking method proposed in this work outperforms other methods and could achieve satisfactory performance in departure flight time prediction, with a high prediction accuracy of up to 89% within a 1 min absolute error and 98% within a 2 min absolute error. Besides, the affecting factors analysis indicates that the operation direction, flight distance, and traffic demand in different areas significantly improve prediction accuracy.
Anomaly Detection Using Deep Learning Respecting the Resources on Board a CubeSat
Authors: Horne Ross , Mauw Sjouke , Mizera Andrzej , Stemper André , Thoemel Jan
Published: August 2023

We explore the feasibility of onboard anomaly detection using artificial neural networks for CubeSat systems and related spacecraft where computing resources are limited. We gather data for training and evaluation using a CubeSat in a laboratory for a scenario where a malfunctioning component affects temperature fluctuations across the control system. This data, published in an open repository, guides the selection of suitable features, neural network architecture, and metrics comprising our anomaly detection algorithm. The precision and recall of the algorithm demonstrate improvements as compared to out-of-limit methods, whereas our open-source implementation for a typical microcontroller exhibits small memory overhead, and hence may coexist with existing control software without introducing new hardware. These features make our solution feasible to deploy on board a CubeSat, and thus on other, more advanced types of satellites.
Carbazole – Quinoxaline Based Bipolar Host Materials for Phosphorescent Organic Light Emitting Diodes (PhOLEDs)
Authors: Keshari Hemant , Ansari Namira , Ansari Farah Naaz Ansari , Chetti Prabhakar , Chaskar Atul
Published: August 2023

Two novel bipolar host materials, 2-(9-phenyl-9H-carbazol-3-yl)quinazolin-4(3H)-one (3CBZ-QZ) and 2-(4-(9H-carbazol-9-yl)phenyl)quinazolin-4(3H)-one (9-CBZQZ), have been designed, synthesized, characterized, and used as host materials for PhOLEDs in this work with the goal to provide balanced charge flux for enhanced PhOLED device efficiency. The design of these compounds incorporates 2-aminobenzamide as an electron acceptor with electron-transporting capabilities and carbazole as an electron donor with hole-transporting properties. Furthermore, the absorption, emission, electrochemical, thermal and theoretical characteristics of these synthesized materials are also reported. The synthesized compounds exhibited relatively high thermal stability with 5% weight loss at temperatures exceeding 380oC. The position of the quinoxaline ring in relation to the phenyl ring of N-phenyl carbazole has been determined to have a substantial impact on the characteristics of the molecules. The conjugation and physical characteristics of these molecules were seen to differ when the linkage location of the donor-acceptor system was changed. A slight change in absorption is observed due to the substitution on carbazole. The emission properties for both molecules are also determined by performing TD-DFT calculations on optimized structures in first excited state (S1). For these compounds, the band gap between the LUMO and HOMO was found to be 3.18 eV and 3.21 eV for 3-CBZ QZ and 9-CBZ QZ respectively. Both molecules are useful for better hole and electron transporting agents for charge transporting materials. They become likely structures for creating very effective electro-phosphorescence devices because of the appropriate HOMO-LUMO gap.
Multi-Objective and Many-Objective Optimisation: Present and Future in de novo Drug Design
Authors: S. Angelo Jaqueline , Alvim Guedes Isabella , J. C. Barbosa Helio , E. Dardenne Laurent
Published: August 2023

de novo Drug Design (dnDD) is a multi-objective optimisation problem (MultiOOP) that aims to design new molecules that satisfy multiple conflicting objectives. Since several desired properties can be considered in the optimisation process, dnDD is naturally categorised as a many-objective optimisation problem (ManyOOP), where more than three objectives must be simultaneously optimised. However, many objectives typically pose several challenges that affect the choice and the design of optimisation methodologies. Herein, we cover the application of MultiOO and ManyOO methods, particularly those based on Evolutionary Computation and Machine Learning techniques, to enlighten their potential application in dnDD. Additionally, we comprehensively analyse how molecular properties used in the optimisation process are applied as either objectives or constraints to the problem. Finally, we discuss future research in ManyOO for dnDD, highlighting two important possible impacts: i) its integration with the development of multi-target approaches to accelerate the discovery of innovative and more efficacious drug therapies and ii) its role as a catalyst for new developments in more fundamental and general methodological frameworks within the ManyOO field.
Highly defective ultra-small M(IV)-MOF nanocrystals
Authors: Dai Shan , Simms Charlotte , Patriarche Gilles , Daturi Marco , Tissot Antoine , Parac-Vogt Tatjana , Serre Christian
Published: August 2023

A precise and concomitant control of both the size and defects in inorganic materials is of importance in many applications, particularly catalysis, as it often results in enhanced properties or emerging new features. So far, applying the strategy of modulation chemistry has been unable to afford high-quality functional Metal-Organic Frameworks (MOFs) nanocrystals with minimized size while exhibiting maximized defects. We report here a general sustainable strategy for the design of highly defective and ultra-small M(IV)-MOFs crystals (ca. 35% missing linker, 4-6 nm). Advanced characterizations have been performed to shed light on the main factors governing the crystallization mechanism and to identify the nature of the defects. The ultra-small Zr-MOFs showed excellent performance in peptide hydrolysis reaction, including high reactivity, selectivity, diffusion, stability, and show emerging tailorable reactivity and selectivity towards peptide bond formation simply by changing the reaction solvent. Therefore, these highly defective ultra-small tetravalent MOFs particles open new perspectives for the development of heterogeneous MOF catalysts with dual functions.
New insights from old data - Hunting for compounds with novel mechanisms using cellular high-throughput screening profiles with Grey Chemical Matter
Authors: Thomas Jason R , Shelton IV Claude , Murphy Jason , Brittain Scott , Bray Mark-Anthony , Aspesi Peter , Concannon John , King Frederick J , Ihry Robert J , Ho Daniel J , Henault Martin , Hadjikyriacou Andrea , Neri Marilisa , Sigoillot Frederic D , Pham Helen T , Shum Matthew , Barys Louise , Jones Michael D , Martin Eric J , Blechschmidt Anke , Rieffel Sébastien , Troxler Thomas J , Mapa Felipa A , Jenkins Jeremy L , Jain Rishi K , Kutchukian Peter S , Schirle Markus , Renner Steffen
Published: August 2023

Identifying high quality chemical starting points is a critical and challenging step in drug discovery, which typically involves screening large compound libraries or repurposing of compounds with known mechanisms of actions (MoAs). Here we introduce a novel cheminformatics approach that mines existing large-scale, phenotypic high throughput screening (HTS) data. Our method aims to identify bioactive compounds with distinct and specific MoAs, serving as a valuable complement to existing focused library collections. This approach identifies chemotypes with selectivity across multiple cell-based assays and characterized by persistent and broad structure activity relationships (SAR). We prospectively demonstrate the validity of the approach in broad cellular profiling assays (cell painting, DRUG-seq, Promotor Signature Profiling) and chemical proteomics experiments where the compounds behave similarly to known chemogenetic libraries, but with a bias towards novel protein targets and required no synthetic effort to improve compound properties. A public set of such compounds is provided based on the PubChem BioAssay dataset for use by the scientific community.
Aplicación de gestores bibliográficos para la producción de textos académicos en estudiantes de un instituto
Authors: Romani Pillpe Guillermo , Macedo Inca Keila Soledad
Published: August 2023

El objetivo de este trabajo fue determinar el efecto de la aplicación de gestores bibliográficos como estrategia para la producción de textos académicos en estudiantes del Instituto de Educación Superior Tecnológico Publico Federico Uranga, Pisco. Para ello, se utilizó la siguiente metodología; el tipo aplicada, nivel explicativo, diseño pre experimental y enfoque cuantitativo. Se trabajó con 38 estudiantes del primer semestre 2021 -1 en el curso Producción e Interpretación de Textos en el Programa de estudios de Industrias Alimentarias. Para la contratación de hipótesis se utilizó la prueba de los rangos con signo de Wilcoxon. Los resultados indicaron que al comparar el rango medio pre-test 35,92 y el post-test 85,74 que si existe diferencia estadísticamente significativa. Se concluyó que el uso de los gestores bibliográficos influye de manera significativa en la producción de textos académicos.
Educación remota y satisfacción académica de los alumnos FCCSS UNFV LIMA – 2020
Authors: Peña Huapaya Pedro Saturnino , Camacho Manrique Nora Amalia
Published: August 2023

El objetivo fue determinar cómo la educación remota se relaciona con la satisfacción académica de los alumnos FCCSS UNFV 2020-1. La investigación fue básica, con alcance o nivel descriptivo y diseño no experimental. Se contó con una población de 503 estudiantes con matrícula regular y asistencia de las tres escuelas de la Facultad de Ciencias de la Comunicación. Luego de aplicar el muestreo probabilístico se contó con 132 alumnos. Los resultados indicaron que los alumnos estan pocos satisfechos con las dimensiones: asignaturas (21.3 %), enseñanza (11.3 %) y contenidos del sílabo (26.8 %), pero con las dimensiones comunicación y plataforma o entorno virtual una satisfaccion es media (43 %). Se concluye que es necesario una plataforma basada en software abierto adaptada a la realidad de la FCCSS-UNFV; capitación a alumnos y docentes en el uso de nuevas tecnologías y entornos virtuales. Adquirir nuevos equipos y módems de alta velocidad para poder estar a la altura de las necesidades de los alumnos y del prestigio de la universidad.
Palabras clave: Educación remota, Tecnología virtual, satisfacción universitaria
Voyerismo académico como síntoma del sistema contemporáneo de las ciencias sociales
Authors: Navarro Hinojoza Ernesto
Published: August 2023

Como nunca antes los individuos podemos estar expuestos a una infinidad de información y podemos mirar y ser mirados, donde el voyerismo se erige como parte fundamental de las modernas relaciones sociodigitales que terminan teniendo una influencia sustancial más allá del mundo digital y trascienden a la esfera de lo real. ¿Qué tanto este comportamiento voyerista se está acentuando en la academia? ¿Qué tan voyeristas somos cuando decidimos “estudiar, diagnosticar y analizar” los entornos rurales y sus problemáticas y no pasar de ese punto? ¿qué tan conscientes estamos siendo de ello? Y ¿qué repercusiones trae consigo esta posición?
Como nunca antes los individuos podemos mirar y ser mirados, donde el voyerismo se erige como parte fundamental de las modernas relaciones socio digitales que terminan teniendo una influencia sustancial más allá del mundo digital y trascienden a la esfera de lo real. ¿Qué tanto este comportamiento voyerista se está acentuando en la academia? ¿Qué tan voyeristas somos cuando decidimos estudiar, diagnosticar y analizar los entornos rurales y sus problemáticas y no pasar de ese punto? Para atender dichas interrogantes, el método llevado a cabo en este trabajo fue el de un análisis reflexivo, en forma de ensayo científico, de algunas evidencias empíricas sobre el comportamiento de los académicos, contrastándolas con ideas de la literatura especializada. Aunque no se pretende dar respuesta tajante a ninguna de estas cuestiones, el objetivo de este trabajo es hacer una autocrítica, resaltando las contradicciones que estamos experimentando en nuestro ejercicio como estudiosos de lo rural. En primera instancia se hace una reflexión sobre la cultura voyerista en la que solemos caer al buscar ser vistos y reconocidos por nuestros pares, y se continua con el análisis de nuestro comportamiento voyerista en el que caemos al intentar hablar por y en nombre de los sujetos de estudio que volvemos objetos al cosificarlos en nuestros análisis. Concluyendo que si bien es cierto esta crítica no es nueva y las generalizaciones son limitantes, el solo hecho de que exista el fenómeno nos debería motivar a pausar el camino y ponernos a cuestionar el rumbo del mismo.
Etnografía de la culinaria tradicional andina en el valle del Mantaro, Junín (1928-1990)
Authors: Arredondo Baquerizo Freder Lorgio , Salazar Solano Roberto
Published: August 2023

El presente artículo de revisión tiene por objetivo, exponer información esencial sobre la culinaria tradicional de las comunidades del valle del Mantaro y situarla en el contexto crítico contemporáneo. Para su desarrollo se desplegó una metodología de revisión bibliográfica de la etnografía local sobre cultura alimentaria; a través, de fichas bibliográficas de registro de datos extraídos. Asimismo, se cualificó como fuente primaria, documentos de divulgación local, que es el más preciso en detalles de valoración de este acervo. De la revisión, se concluyó que la diversidad culinaria, explicitada en técnicas y saberes tradicionales, fueron determinantes de la identidad de sus productores en el valle del Mantaro. También, que el registro etnográfico de 1928 a 1990 evidencia una cultura de la comida sublimada en los afanes de sus protagonistas.
Gestión del fan page de la PNP en la campaña “Yo me quedo en casa” y su relación con la imagen institucional, 2020
Authors: Ríos Chanca Edvan Agripino
Published: August 2023

La presente investigación titulada Gestión del Fan page de la PNP en la campaña “Yo me quedo en casa” y su relación con la imagen institucional, 2020 presentó el objetivo de establecer la relación concurrente entre el Fan page de la PNP en la campaña “Yo me quedo en casa” con su imagen institucional en el 2020. Respecto a la metodología, esta investigación presenta un enfoque cuantitativo, de tipo o alcance correlacional, de diseño no experimental y corte transversal o transeccional. Entre las conclusiones abordadas se halló la existencia de relación directa y significativa (r = 0.687) del Fan page analizado y la imagen institucional de la PNP en el 2020, y la relación directa, significativa y alta (r = 0.774) entre el contenido de este Fan page y su imagen institucional en el 2020. La utilización de videos, imágenes, fotografías y memes evidenciaron una alta relación en la imagen institucional. Otra conclusión fue que los comentarios y likes también son elementos que ayudan a optimizar la imagen de la institución. Finalmente, se concluye que existe relación directa, significativa y alta (r = 0.721) entre la interactividad del Fan page de la PNP y su imagen institucional en el 2020. Las divulgaciones en el Fan page de la PNP fueron interesantes, según manifiestan los encuestados, es por ello por lo que la cantidad de veces compartidas y un mayor número de likes a las publicaciones son considerados como elementos importantes en la alta relación que se obtuvo con la imagen institucional de esta entidad pública.
ESTADO DO CONHECIMENTO: ENSINO DE BIOLOGIA SOBRE O CERRADO EM TEXTOS ACADÊMICOS
Authors: Rodrigues Naielly Christhiny Paz , Moraes Mariuce Campos de
Published: August 2023

Este artigo apresenta um estado do conhecimento acerca do Ensino de Biologia com ênfase no Cerrado, considerando a publicação de dissertações e artigos científicos e a necessidade de conhecer pesquisas com abordagem crítica e relevante para a sensibilização das pessoas sobre a importância socioambiental do bioma. As publicações selecionadas compreendem aquelas que associam os temas Cerrado, Ensino de Biologia, Ensino de Ecologia e Ensino Médio e foram publicadas entre os anos de 2016 a 2021. Nessas pesquisas publicadas encontramos, por um lado, a implementação de diferentes estratégias didáticas, como produções audiovisuais, sequências didáticas, aulas de campo, jogos de tabuleiro, livros didáticos, livros paradidáticos, palestras e atividades envolvendo o plantio de mudas de espécies típicas do Cerrado. Por outro lado, nota-se pouca ênfase no ensino sobre o Cerrado a partir de um viés sistêmico. Tendo isso em vista, os resultados apontam para a importância de materiais de divulgação sobre o Cerrado a partir dessa uma perspectiva, dada a necessidade de estabelecer uma relação de valorização do bioma como sistema complexo, considerando sua relevância nacional.
APRENDIZAGEM DA DOCÊNCIA E FORMAÇÃO DE PROFESSORES QUE ENSINAM MATEMÁTICA: UMA REVISÃO DE LITERATURA
Authors: Negrão Felipe da Costa , Gonzaga Amarildo Menezes , Azevedo Rosa Oliveira Marins , Anic Cinara Calvi
Published: August 2023

Este artigo teve o objetivo de identificar a produção científica sobre aprendizagem da docência e formação inicial em pesquisas com professores polivalentes que ensinam Matemática. O conceito de professores polivalentes aplica-se aos docentes formados em Pedagogia com habilitação para a docência na Educação Infantil e nos Anos Iniciais do Ensino Fundamental. Metodologicamente, adotamos um protocolo de revisão de literatura com a string “aprendizagem da docência” AND “formação inicial” AND “professores que ensinam Matemática” no período de 2017 a 2022 em trabalhos escritos em língua portuguesa disponíveis na Biblioteca Digital Brasileira de Teses e Dissertações (BDTD). Este protocolo foi constituído por critérios de inclusão e exclusão, além de questões-norteadoras que subsidiaram a análise qualitativa das produções. Diante disso, três pesquisas foram selecionadas e analisadas a partir do viés interpretativo da espiral de Creswell (2014), o que nos reportou para a composição de duas categorias analíticas: a) aprendizagem da docência; e b) formação inicial de professores que ensinam Matemática. Os resultados dessas pesquisas reforçam a importância de uma formação inicial para professores polivalentes que ensinam Matemática, baseada em estratégias de ensino que integrem conhecimentos matemáticos, didáticos e pedagógicos. Além disso, destacamos a necessidade de incentivar a consciência de que o desenvolvimento profissional docente é um processo contínuo.
O QUE MOSTRAM OS ESTUDOS SOBRE OS CONTEÚDOS PRESENTES NOS LIVROS DIDÁTICOS PARA O ENSINO DE PILHAS?
Authors: Domingues Carlos Alberto Pereira , Cintra Elaine Pavini
Published: August 2023

Os livros didáticos estão presentes em uma significativa proporção de escolas, fazem parte do cotidiano escolar e muitas vezes é o único material didático utilizado para o ensino. Assim, são necessários constantes acompanhamentos dos conteúdos e das abordagens neles apresentados, principalmente sobre temáticas que envolvem conceitos mais abstratos. Neste manuscrito são apresentados os resultados de uma pesquisa bibliográfica cujo objetivo foi analisar trabalhos publicados na literatura que investigaram como a temática das pilhas galvânicas são abordadas nos livros didáticos. O levantamento bibliográfico foi realizado nas bases de dados Google Acadêmico, Scielo e Portal Capes. Após aplicados critérios de seleção e exclusão, foram eleitas doze publicações que constituíram o corpus desta pesquisa. As discussões foram pautadas em quatro categorias de análise, a saber: Abordagem Experimental, Enfoque CTSA/Ambiental, Imagens e Representações e Enfoque Teórico e Conceitual. Os resultados indicam que aspectos importantes, envolvendo conceitos de eletroquímica, vêm merecendo a atenção de estudiosos, garantindo avanços na qualidade do conteúdo disponibilizados nos livros. Apontam também obstáculos que ainda precisam ser superados, como as abordagens conceituais equivocadas, o uso recorrente de imagens com função meramente ilustrativa e, a ocorrência de propostas experimentais ainda com caráter procedimental.
Study of indium antimonide single crystals obtained by the modernized Chokhralsky method in several crystallographic directions
Authors: Komarovsky N. Yu. , Molodtsova E. V. , Belov A. G. , Grishechkin M. B. , Kozlov R. Yu. , Kormilitsina S. S. , Zhuravlev E. O. , Nestyurkin M. S.
Published: August 2023

Single-crystal indium antimonide InSb is an indispensable material in such branches of solid-state electronics as opto- and nanoelectronics. In turn, the dislocation density and the character of their distribution, which directly depend on the technological parameters of the growth process, considerably determine the physical and mechanical properties of the material. We present the results of studying InSb single crystals obtained by the modernized Czochralski method in the crystallographic directions [100], [111], and [112]. The effect of growth conditions (axial and radial temperature gradients at the crystallization front) on the dislocation structure of InSb plates and the structural properties of the plates were analyzed. Using the method of selective etching it was shown that the number of etching pits on the wafers with different orientations differs by approximately an order of magnitude (103 cm–2 for plane (111) and 102 cm–2 for (100)). Number of etch pits for the (100) plane is commensurate with their number in crystals grown in the [112] and [100] directions. Probably, the maximum dislocation density in InSb single crystals can be considered as a material constant, and the increased strength of single crystals grown at lower axial gradients at the crystallization front is related to the formation of a characteristic ensemble of point defects along the dislocation line through diffusion. It is shown that InSb wafers [112] (100) exhibit the best physical and mechanical properties. The results obtained can be used in the manufacture of structures for photodetectors, in particular, in plate processing (cutting, grinding and polishing) to optimize technological processes.
Antimicrobial susceptibility testing and reporting practices of public hospital microbiology laboratories in Greece, 2022: A national observational survey and call for action
Authors: Karagiannidou Sofia , Kopsidas Ioannis , Polemis Michalis , Tryfinopoulou Kyriaki , Zaoutis Theoklis
Published: August 2023

Antimicrobial resistance (AMR) in Greece is among the highest across the European Union/European Economic Area (EU/EEA), with high AMR rates even to last-line antibiotics. To better understand the clinical microbiology laboratory practices and capacities in species identification and antimicrobial susceptibility testing (AST) across public healthcare establishments in Greece, we sent a questionnaire to 98 of 128 public hospital microbiology laboratories between 1 February and 1 April 2022. Of the 73.5% (72/98) that responded, 51.4% (37/72) reported using EUCAST guidelines. Two of three laboratories used an automated instrument for species identification and AST for all laboratory samples. Broth microdilution for colistin susceptibility testing was used by 46 of the laboratories, more frequently in larger (> 400 beds) versus smaller (< 400 beds) hospitals (90.5% (19/21) vs 52.9% (27/51) respectively, p = 0.011). MALDI-TOF mass spectrometry was available in one of 10 laboratories, and more often in larger compared to smaller hospitals (p = 0.035). Although the majority of laboratories had a laboratory information system (LIS) in place, only half had the capacity to extract data directly from the LIS for the purpose of AMR surveillance; 73.6% (53/72) used restrictive antibiograms. Public microbiology laboratory AMR capacities in Greece require improvement, prioritising interventions for EUCAST guidelines implementation.
Seroprevalence, seroconversion and seroreversion of Borrelia burgdorferi-specific IgG antibodies in two population-based studies in children and adolescents, Germany, 2003 to 2006 and 2014 to 2017
Authors: Böhm Stefanie , Woudenberg Tom , Stark Klaus , Böhmer Merle M , Katz Katharina , Kuhnert Ronny , Schlaud Martin , Wilking Hendrik , Fingerle Volker
Published: August 2023

Background

Lyme borreliosis (LB), caused by Borrelia burgdorferi (Bb), is the most common tick-borne infection in Germany. Antibodies against Bb are prevalent in the general population but information on temporal changes of prevalence and estimates of seroconversion (seroincidence) and seroreversion are lacking, especially for children and adolescents.

Aim

We aimed at assessing antibodies against Bb and factors associated with seropositivity in children and adolescents in Germany.

Methods

We estimated seroprevalence via two consecutive cross-sectional surveys (2003–2006 and 2014–2017). Based on a longitudinal survey component, we estimated annual seroconversion/seroreversion rates.

Results

Seroprevalence was 4.4% (95% confidence interval (CI): 3.9–4.9%) from 2003 to 2006 and 4.1% (95% CI: 3.2–5.1%) from 2014 to 2017. Seroprevalence increased with age, was higher in male children, the south-eastern regions of Germany and among those with a high socioeconomic status. The annual seroconversion rate was 0.3% and the annual seroreversion rate 3.9%. Males were more likely to seroconvert compared with females. Low antibody levels were the main predictor of seroreversion.

Conclusion

We did not detect a change in seroprevalence in children and adolescents in Germany over a period of 11 years. Potential long-term changes, for example due to climatic changes, need to be assessed in consecutive serosurveys. Seroconversion was more likely among children and adolescents than among adults, representing a target group for preventive measures. Seroreversion rates are over twice as high in children and adolescents compared with previous studies among adults. Thus, seroprevalence estimates and seroconversion rates in children are likely underestimated.