bluuebunny/crossref_metadata_2025 huggingface dataset:
HIGH-DOSE-RATE AND LOW-DOSE-RATE BRACHYTHERAPY AS MONOTHERAPY FOR CLINICALLY LOCALIZED PROSTATE CANCER
Authors: Solodkiy Vladimir , Pavlov Andrey , Tsybulskiy Aleksey , Pchelintsev Aleksandr , Moshurov Ivan , Korotkikh Nataliya , Kamenev Dmitriy
Published: November 2020

PURPOSE:To compare the outcome of high-dose-rate interstitial brachytherapy (HDR-BT) and low-dose-ratebrachytherapy (LDR-BT) as monotherapy for localized prostate cancer of low and intermediate risks progression.
METHODS AND MATERIALS: The study included 165 patients with localized prostate cancer in low and intermediate progression risk groups. We compared 65 patients treated with HDR-BT and 100 patients with LDR-BT as monotherapy. LDR-BT treated advanced disease with more hormonal therapy than HDR-BT. All patients were in low and intermediate risk groups for prostate cancer progression. HDR-BT as monotherapy was delivered in 2 fractions of 15 Gy, two weeks apart. LDR-BT was performed in a standard mode of 145 Gy. The median observation was 32 months. All patients gave written informed consent.
RESULTS: Overall biochemical free survival rate (BFSR) is 95,8%. There are 7 people having a growing prostatic specific antigen (PSA) while the case follow-up (in the group HDR-BT - 2 patients, LDR - 5 patients). Two recurrence cases with metastases in lymph nodes and bones were brought out as a result of 68Ga-PSMA PET examination in the group of HDR-BT. In 4 cases out of 5 LDR-BT, a local recurrence was detected (p=0,085). All cases of relapse were found in patients at intermediate risk (p = 0,041). LDR-BT showed a higher incidence of genitourinary (GU) toxicity grade >2 than that of HDR-BT in the acute phase and grade 1 toxicity in late phase. Accumulated incidence of late grade >2 GU and GU toxicity was equivalent between HDR-BT and LDR-BT.
CONCLUSION: HDR-BT monotherapy showed an equivalent outcome to that of LDR-BT for low and intermediate risk patients. LDR-BT showed equivalent incidence of grade >2 late GU toxicities and higher grade >2 acute GU toxicity as that of HDR-BT as a monotherapy.
SKIN MELANOMA INCIDENCE IN WORKERS OCUPATIONALLY EXPOSED TO IONIZING RADIATION OVER A PROLONGED PERIOD
Authors: Rybkina Valentina , Azizova Tamara , Grigoreva Yevgeniya
Published: November 2020

Purpose of the study. The study is aimed to investigate skin melanoma incidence in workers occupationally exposed to radiation over a prolonged period.
Materials and methods. Skin melanoma incidence was studied in a cohort of workers first employed at nuclear facility Mayak Production Association (PA) between 1948 and 1982 who had been followed up till 31.12.2013 (22,377 individuals). Mean cumulative doses from external gamma-rays over the whole follow-up period were 0.54±0.001 Sv in males and 0.44±0.002 Sv in females. Incident rates for skin melanoma were analyzed by sex, attained age, calendar period of diagnostics and radiation dose using worldwide standard and the direct standardization technique.
Results. 60 skin melanoma cases (37 in males and 23 in females) were registered in the study cohort over the whole follow-up period. The standardized skin melanoma incident rate was 8.51±1.46 in males and 8.78±2.27 in females per 100000 workers revealing statistically higher rates compared to corresponding rates for general populations of the Russian Federation, Urals Federal District and Chelyabinsk region. Skin melanoma incidence was significantly increased in the period of 1994 - 2013 as compared to the period of 1974 - 1993. Skin melanoma incidence excess in females was greater than that for males. Skin melanoma incidence increment in females was mostly driven by modifications of disease occurrence risk while in males it was driven by a combined effect of age pattern modifications in the study cohort and increase of disease risk.
Conclusions. Skin melanoma incidence rates in the cohort of workers occupationally exposed to ionizing radiation over a prolonged period were associated with sex and attained age workers and the calendar period of diagnostics. No significant association of skin melanoma incidence with dose from external gamma-rays was observed. A significantly increasing trend was observed for skin melanoma incidence by the end of the follow-up in both males and females.
MODIFICATING ACTION OF DICLOFENAC ON EFFECTS OF PHOTODYNAMIC THERAPY – IN VIVO STUDY
Authors: Kireeva Galina , Kruglov Stepan , Tarasov A. , Plakhov Ye. , Gubareva Yekaterina , Maydin Mikhail , Panchenko Andrey , Grishacheva Tatyana
Published: November 2020

Introduction. Non-steroidal anti-inflammatory drugs and, in particular, diclofenac, are considered as drugs with a potentially anticarcinogenic effect and can be used to enhance the effects of antitumor therapy.
Aim. To evaluate the effectiveness of diclofenac as a potential modifier of photodynamic therapy (PDT) in vivo in Ehrlich tumor model in mice.
Materials and methods. The study was conducted on male mice of BALB/C strain with intradermally grafted Ehrlich carcinoma. Experimental procedures were performed on day 7 after tumor inoculation. The control group did not receive treatment, in one group only diclofenac was administered, photosensitizer was administered in three groups (photoditazin, 5 mg / kg, intravenously once), tumor was irradiated with a laser (ALOD, 662 nm) or PDT was performed, respectively, and in three groups the procedures indicated above in each case were combined with the administration of diclofenac. 2 series of experiments were conducted to assess the reproducibility of the results. The size of the tumor was recorded after exposure.
Results. In the first series of the experiment, in all groups with the administration of diclofenac (45 mg/kg/day), a high animal mortality was unexpectedly observed, associated with the toxic effect of diclofenac, which required a change in its administration regime and dose (15 mg/kg) in the second series of the experiment. The administration of diclofenac did not significantly affect the efficacy of PDT, and also did not have a modifying effect in other groups (with the introduction of a photosensitizer or laser irradiation) compared with similar groups without diclofenac. PDT with photoditazine turned out to be the most effective treatment regimen: in 8 out of 10 mice in the group from the 21th day after procedure the tumors were not recorded, the animals were alive until the end of the observation for 60 days. The introduction of a photosensitizer and radiation without a photosensitizer did not lead to a significant inhibition of tumor growth.
Conclusion. In vivo on a model of intradermally grafted Ehrlich tumor in mice, diclofenac does not have a modifying effect on the antitumor effects of PDT.
METASTASIS PRIMARY MYXOFIBROSARCOMA FROM THE HEART OF IN BRAIN. CASE REPORT
Authors: Rynda Artemiy , Olyushin Viktor , Zabrodskaya Yuliya , Rostovtsev Dmitriy
Published: November 2020

Background: myxofibrosarcoma is rare a fibroblastic neoplasm with myxoid matrix.
Objective: to show rare case of heart myxofibrosarcoma with brain metastasis.
Materials and methods: 52-year-old women, clinical manifestations were headaches, left hemiparesis, intellection-amnestic disorder.
Results: radical operation with intraoperative photodynamic therapy has been executed.
Šiuolaikinės plaučių vėžio diagnostikos ir gydymo galimybės
Authors: Stravinskaitė Kristina
Published: November 2020

Plaučių vėžys – viena dažniausių piktybinių ligų pasaulyje. Plaučių vėžio diagnozė dažniausiai nustatoma pavėluotai, esant IV ar III stadijai, kai radikalus gydymas negalimas. Straipsnyje aptariamos šiuolaikinės plaučių vėžio diagnostikos ir gydymo galimybės, padėsiančios pagerinti šia liga sergančių pacientų prognozę. Plaučių vėžys – viena dažniausių piktybinių ligų pasaulyje. Plaučių vėžio diagnozė dažniausiai nustatoma pavėluotai, esant IV ar III stadijai, kai radikalus gydymas negalimas. Straipsnyje aptariamos šiuolaikinės plaučių vėžio diagnostikos ir gydymo galimybės, padėsiančios pagerinti šia liga sergančių pacientų prognozę.
Alfa­1 antitripsino stoka – ar tikrai reta patologija
Authors: Serapinas Danielius
Published: November 2020

Alfa-1 antitripsino (AAT) stoka – viena dažniausių genetinių ligų europiečių populiacijoje, pasireiškianti maždaug 1 iš 1600–5000 asmenų. AAT – proteazių inhibitorius, apsaugantis plaučių audinį nuo žalingo proteazių poveikio. Kai šios antiproteazės stinga, suyra alveolių sienelės, formuojasi lėtinė obstrukcinė plaučių liga bei didėja rizika sirgti lėtinėmis kepenų ligomis. AAT stoka patikimai susijusi su ankstyvu LOPL išsivystymu ir sparčiu ligos progresavimu, ankstyvu neįgalumu, trumpesne gyvenimo trukme. AAT stoka nustatoma 1–3 proc. sergančiųjų LOPL. Kad stokotų AAT, pacientas turi būti gavęs po pakitusį PI geną (PI*Z, PI*S, PI*Null) iš abiejų tėvų, nes liga paveldima autosominiu recesyviniu būdu. Daugeliu atvejų LOPL sergantiems pacientams AAT stoka lieka nediagnozuota. Taigi anksti ištirti LOPL pacientus dėl alfa-1 antitripsino stokos yra svarbu nustatant ligos priežastinį veiksnį, prognozuojant ligos eigą, parenkant gydymą bei profilaktiką.
Kvėpavimo organų ligomis sergančių ligonių darbingumo lygio nustatymas
Authors: Naseckienė Violeta
Published: November 2020

Darbingumo lygio (DL) nustatymas yra aktuali tema tiek neįgaliesiems, tiek juos gydantiems gydytojams, turinti platų atgarsį ir visuomenėje. Šio straipsnio tikslas – supažindinti su DL vertinimo naujovėmis ir akcentuoti reikalavimus bei dažniausiai pasitaikančius trūkumus siunčiant ligonius, sergančius kvėpavimo organų ligomis, į Neįgalumo ir darbingumo nustatymo tarnybą (NDNT) DL nustatyti.
Aspergiliozė
Authors: Januškevičiūtė Asta
Published: November 2020

Į Panevėžio ligoninę paguldyta 43 metų moteris, mies­to gyventoja, dirbanti bendrosios praktikos slaugytoja. Indikacija hospitalizuoti – užsitęsęs dešiniojo plaučio uždegimas.
Naujosios dilgėlinės diagnozavimo ir gydymo rekomendacijos
Authors: Leišytė Palmira
Published: November 2020

Dilgėlinė – dažna odos liga. Skiriami įvairūs jos tipai ir potipiai. Jie atsispindi klasifikacijoje, kuri sudaryta atsižvelgiant į pūkšlių trukmę, dilgėlinės kartojimosi trukmę, sukeliančiuosius veiksnius. Naujosiose rekomendacijose pa-teikiami įvairių dilgėlinės tipų ir potipių diagnostikos ir gydymo principai atsižvelgiant į šiuolaikinį dilgėlinės priežasčių ir patomechanizmų supratimą. Pateikiamas lėtinės dilgėlinės gydymo algoritmas.
Itin smulkių dalelių sudėtinis beklometazono dipropionato ir formoterolio vaistas astmai gydyti: įrodymai ir perspektyva
Authors: Nutautienė Rūta
Published: November 2020

Gydymas sudėtiniu beklametazono ir formaterolio vaistu ypatingas tuo, kad naująją Modulite® technologija pagaminto vaisto dalelės yra labai mažo dydžio ir įkvėptos gerai pasiskirsto smulkiuosiuose apatiniuose kvėpavimo takuose.
Piktybinės pleuros mezoteliomos diagnostika ir gydymas
Authors: Vagulienė Neringa , Žemaitis Marius , Vaitkus Mindaugas , Miliauskas Skaidrius
Published: November 2020

Straipsnyje aptariami piktybinės pleuros mezoteliomos diagnostikos ir gydymo principai.
The Craftsmanship Of The Emirate Of Bukhara At The Second Half Of The XIX Century - The Beginning Of The XX Century
Authors:   Associate Professor, Candidate Of Historical Sciences, Department Of Archaeology Of Uzbekistan, National University Of Uzbekistan, Fayzulla Ochildiev
Published: November 2020

This article describes the development of handicrafts in the second half of the XIX century and the beginning of the XX century in the Emirate of Bukhara. In the Emirate of Bukhara from ancient times developed weaving, embroidery, tanning, carpet weaving, pottery, blacksmithing, coppersmithing, carving, jewelry, painting and other crafts.
Conflicts In Approaches To Cognitive And Conceptual Metaphorical Classification
Authors:   Associate Professor, Termiz State University, Termiz, Uzbekistan, Makhmaraimova Sh.T.
Published: November 2020

The article provides a scientific commentary on the phenomena of cognitive and conceptual metaphors, as well as a response to existing theories in world linguistics. The different aspects of cognitive and conceptual metaphors are also revealed, with particular emphasis on J. Lakoff's classifications in this regard.
Shashi Deshpande’s the Intrusion and Other Stories: an Applause of Womanhood
Authors: Mehta Rajesh
Published: November 2020

Shashi Deshpande, the recipient of 1990 SahityaAkademi Award, penned her first short story collection The Legacy and Other Stories in the year 1978. She started writing short stories at a mature age of thirty to record her trip to England with her husband. Since then, she has published five collections of short stories. The fifth collection The Intrusion and Other Stories got published in 1993 when she was already an established Indian writer writing in English. The anthology narrates nineteen stories of women protagonists. All the protagonists of these stories have one or the other wish to fulfil, during the course of the action; they struggle hard to fulfil their dreams and aspirations. The author captures the touching knots of these women, either young or old, struggling against disappointment, failed love, and the death of their near ones. At times funny, at times disturbing, these stories
Közrend, közbiztonság, rendészet a keresztény közgondolkodásban
Authors: Tihanyi Miklós
Published: November 2020

The author provides a comparative, Catholic and Protestant analysis of the ethics of the concepts of public order and public safety.
Two new Leptobrachella species (Anura, Megophryidae) from the Yunnan-Guizhou Plateau, southwestern China
Authors: Wang Jian , Lyu Zhi-Tong , Qi Shuo , Zeng Zhao-Chi , Zhang Wen-Xiang , Lu Long-Shan , Wang Ying-Yong
Published: November 2020

Two new toad species of the genusLeptobrachellaare described from the Yunnan-Guizhou Plateau of China, based on the combination of molecular and morphological data. The description ofLeptobrachella asperaWang, Lyu, Qi & Wang,sp. nov.from Huanglianshan Nature Reserve represents the thirteenthLeptobrachellaspecies known from Yunnan Province, and the description ofLeptobrachella dorsospinaWang, Lyu, Qi & Wang,sp. nov.from Yushe Forest Park represents the sixthLeptobrachellaspecies known from Guizhou Province. These new discoveries further emphasize the extremely high diversity of theLeptobrachellatoads in these regions.
Deuil d’un enfant dans la famille : une prise en charge psychanalytique groupale comme issue possible ?
Authors: Guilleux-Keller Sandrine , Aubry Karin
Published: November 2020

Cet article aborde la question du deuil et plus particulièrement du deuil d’un enfant dans une famille. Ce deuil traumatique vient bouleverser l’ordre générationnel. Il confronte l’ensemble du groupe familial à un impensable. Comment peut-on accompagner au mieux une famille frappée par un tel drame ? Est-il pertinent de prendre en charge l’ensemble de la famille ? La plupart des auteurs qui ont travaillé ces questions sont d’orientation systémique. Les auteures, psychologues et thérapeutes familiales psychanalytiques, se proposent ici d’aborder cette thématique sous l’angle de la théorie psychanalytique individuelle et groupale. Elles illustrent leurs propos au travers d’une situation clinique afin de montrer l’évolution du travail de deuil au sein d’une famille confrontée à la perte d’un enfant.
Désorganisation des liens familiaux et réactivation des conflits chez les aidants confrontés à la maladie… d’Alzheimer de leur mère
Authors: Bonnet-Llompart Magalie , Laurent Alexandra
Published: November 2020

Prendre soin d’un parent souffrant de la maladie d’Alzheimer place l’ensemble de la famille dans des circonstances complexes et difficiles. Cet article s’emploie à comprendre comment la maladie d’Alzheimer vient convoquer l’histoire familiale, ses conflits et ses traces du négatif, perturbant à la fois les liens familiaux et l’inscription des proches dans leur rôle d’aidant. Les auteures rendent compte d’entretiens cliniques à visée de recherche menés auprès d’une fratrie de quatre sœurs confrontées à la dépendance de leur mère atteinte de la maladie d’Alzheimer. À partir d’une analyse phénoménologique, elles montrent l’importance de la désorganisation des liens familiaux et la réactivation des conflits dans l’organisation concrète des aidants autour du parent malade. Les enfants confrontés à la maladie grave d’un parent doivent non seulement réaliser un travail d’acceptation de la maladie, mais aussi réélaborer l’histoire familiale ainsi réactivée.
Perceptions, connaissances et attitudes concernant les naissances gémellaires en Afrique subsaharienne : le cas du Burkina Faso et du Sénégal
Authors: Ouedraogo Adama
Published: November 2020

En Afrique subsaharienne, les naissances gémellaires sont entourées de nombreuses perceptions et de diverses pratiques culturelles. La présente étude qui fait suite à des travaux (quantitatifs) en lien avec le taux d’accouchement gémellaire ainsi que la surmortalité des enfants jumeaux s’intéresse aux perceptions, connaissances et attitudes des Subsahariens concernant les naissances gémellaires. Elle analyse des entretiens qualitatifs recueillis au Burkina Faso et au Sénégal auprès de jumeaux, de parents de jumeaux et d’acteurs associatifs, médicaux et religieux (94 entretiens). Les principaux résultats indiquent que le jumeau subsaharien demeure un être « extraordinaire », au carrefour de plusieurs mondes culturels ; ils indiquent aussi qu’il est moins craint et moins menacé de nos jours, mais peut-être plus exposé qu’autrefois par une mendicité chronique des mères.
La production participative dans l’élaboration des politiques publiques
Authors: Aitamurto Tanja , Richet Isabelle
Published: November 2020

Les gouvernements font un usage croissant de la « production participative » ( crowdsourcing ) pour mobiliser les citoyens et leurs connaissances. Cet outil qui permet de déployer sur internet une collaboration à grande échelle constitue une innovation démocratique pour l’élaboration des politiques publiques. L’article analyse les caractéristiques, les avantages et les difficultés qu’il présente en s’appuyant sur des exemples concrets.
Remettre le citoyen au cœur de la décision publique
Authors: Leyrit Christian
Published: November 2020

Comment rendre plus légitimes les décisions publiques, concernant notamment les projets d’équipement et d’aménagement du territoire ? Comment remettre les citoyens au cœur de la décision publique ? Leurs frustrations sont importantes, et leur demande de participation d’autant plus forte que le modèle politique apparaît en crise. Ils attendent et exigent la mise en place d’une nouvelle gouvernance publique, fondée non plus sur les rapports de force mais sur une co-construction de l’intérêt général. Puisse l’ensemble des responsables politiques, sociaux, économiques et associatifs, s’engager dans cette voie, seule à même de restaurer la confiance et de reconstruire le lien social.
Le grand débat national : la démocratie participative à grande échelle
Authors: Perrineau Pascal
Published: November 2020

Le processus du « grand débat national » a été inventé en décembre 2018 pour tenter de trouver une issue à la crise des « gilets jaunes ». Cette expérience de démocratie participative à très grande échelle est une première mondiale impliquant environ deux millions de citoyens qui, pendant deux mois (15 janvier-15 mars 2019), ont débattu et proposé des perspectives sur quatre grands thèmes proposés par le président de la République. Au-delà de l’expérience démocratique en tant que telle, les effets de ce grand débat sur la vie politique française ont été modestes.
La représentation de l’autre
Authors: Gay Déborah
Published: November 2020

Le but de cet article est de montrer comment une fiction audiovisuelle est porteuse de la vision d’un Autre exotisé et par quelles actions des comédiens racisés peuvent modifier leurs personnages à la marge. Pour cela, nous avons réalisé une enquête ethnographique de sept mois sur une websérie LGBT. Dans le cadre de cette fiction, deux des personnages sont d’origine maghrébine : le personnage principal et sa sœur. Nous nous focalisons ici sur la période de tournage pour pouvoir analyser l’agentivité des comédiens racisés incarnant ces rôles dans le cadre d’une production destinée au web. Ces comédiens tirent parti de flous dans le scénario pour nuancer la représentation d’une minorité à laquelle ils appartiennent, tout en restant dans un rapport en tension avec les réalisateurs et le scénariste qui gardent la responsabilité de la direction d’acteurs, du montage et de l’écriture du récit.
Black to Detroit
Authors: Benabdellah Alia
Published: November 2020

Créée à l’orée des années 1980 par des musiciens afro-américains dans la ville de Détroit, inspirés par la musique house de la ville voisine de Chicago et l’environnement machinique de Détroit, la techno a bénéficié d’une rapide diffusion internationale qui s’accompagne d’une production médiatique importante. Si le récit médiatique initial présente bien le genre en continuité des productions culturelles et artistiques noires américaines et révèle l’importance à cet égard de l’infrastructure médiatique locale et notamment des émissions de radio The Midnight Funk Association et de télévision The New Dance Show , l’exportation européenne de la techno va inaugurer un récit médiatique différent. Dans une perspective attentive au processus de racialisation dans la production médiatique, cet article, appuyé sur des entretiens et des observations à Détroit et à Berlin, s’attache à montrer comment ce récit européen participe d’un blanchiment du genre musical en minimisant son apport noir fondateur.
Les pensions de survie en Grèce sous le feu croisé des plans de sauvetage
Authors: Tinios Platon , Georgiadis Thomas , Chouzouris Michalis
Published: November 2020

Cet article tente de cerner comment et pourquoi les pensionnés survivants, c’est-à-dire les veuves et les orphelins dépendant des droits dérivés de l’assurance sociale, ont souffert des ajustements de la réforme des retraites, attendue de longue date et supervisée par les institutions européennes dans le cadre du plan de sauvetage de la Grèce, de 2010 à 2018. Cette situation est due avant tout à des lacunes de gouvernance, notamment, à l’incapacité d’équilibrer des considérations conflictuelles. La fragmentation du système a retardé la réforme et préservé les inégalités : d’un côté, certaines veuves n’avaient aucun droit à pension, tandis que les filles non mariées de certains fonctionnaires percevaient des pensions complètes. D’après les données Share, cette diversité s’est traduite par des différences de comportement selon la cohorte ou le prestataire de pension. Par exemple, les droits des veuves semblent avoir influencé les comportements matrimoniaux et l’on peut observer un écart d’âge assez important entre les conjoints. Dans le cadre des réformes prévues par le plan de sauvetage, les pensions ont été réévaluées de façon rétroactive afin de réaliser des économies budgétaires. Ces réformes prévoyaient également un programme de modernisation comportant un certain degré de personnalisation, qui a particulièrement affecté les retraités survivants. Bien que certains de ces changements soient apparemment en train de s’inverser après le sauvetage, la question n’est pas encore réglée.
Transformer la culture de l’habiter
Authors: Menu Flavien
Published: November 2020

Y a-t-il une alternative au mode d’habitation hérité de la société industrielle et qui tienne compte des mutations sociétales de nos modes de vie ? Des initiatives ont émergé, en Europe et aux États-Unis, adoptant une démarche collective, comme le community-led housing et d’autres formes de co-housing . Elles ont toutes pour principe de mettre le foncier en commun et de faire de tous les habitants des acteurs du changement.
L’alignement des planètes
Authors: Charbonneau Jean-Pierre
Published: November 2020

Le changement de mode de vie et d’ambiance urbaine provoqué par l’effet du confinement peut constituer une opportunité pour passer enfin à l’acte dans le domaine écologique et dans ses implications urbaines. En l’occurrence, certaines actions apparaissent d’une nécessité de plus en plus évidente, comme celle d’élargir les espaces destinés aux piétons et ceux dévolus aux vélos. De même, paraît s’imposer celle de supprimer les voitures devant les magasins et surtout devant les écoles. Plus généralement, ce sont les projets urbains qui doivent être revus. Pour cela, les collectivités locales doivent se doter des compétences nécessaires, en l’occurrence recourir à des professionnels aguerris.
On the convexity for the range set of two quadratic functions
Authors: Nguyen Huu-Quang , Chu Ya-Chi , Sheu Ruey-Lin
Published: November 2020

Given \begin{document}$ n\times n $\end{document} symmetric matrices \begin{document}$ A $\end{document} and \begin{document}$ B, $\end{document} Dines in 1941 proved that the joint range set \begin{document}$ \{(x^TAx, x^TBx)|\; x\in\mathbb{R}^n\} $\end{document} is always convex. Our paper is concerned with non-homogeneous extension of the Dines theorem for the range set \begin{document}$ \mathbf{R}(f, g) = \{\left(f(x), g(x)\right)|\; x \in \mathbb{R}^n \}, $\end{document} \begin{document}$ f(x) = x^T A x + 2a^T x + a_0 $\end{document} and \begin{document}$ g(x) = x^T B x + 2b^T x + b_0. $\end{document} We show that \begin{document}$ \mathbf{R}(f, g) $\end{document} is convex if, and only if, any pair of level sets, \begin{document}$ \{x\in\mathbb{R}^n|f(x) = \alpha\} $\end{document} and \begin{document}$ \{x\in\mathbb{R}^n|g(x) = \beta\} $\end{document}, do not separate each other. With the novel geometric concept about separation, we provide a polynomial-time procedure to practically check whether a given \begin{document}$ \mathbf{R}(f, g) $\end{document} is convex or not.
First order necessary conditions of optimality for the two dimensional tidal dynamics system
Authors: Mohan Manil T.
Published: November 2020

In this work, we consider the two dimensional tidal dynamics equations in a bounded domain and address some optimal control problems like total energy minimization, minimization of dissipation of energy of the flow, etc. We also examine an another interesting control problem which is similar to that of the data assimilation problems in meteorology of obtaining unknown initial data, when the system under consideration is the tidal dynamics, using optimal control techniques. For these cases, different distributed optimal control problems are formulated as the minimization of suitable cost functionals subject to the controlled two dimensional tidal dynamics system. The existence of an optimal control as well as the first order necessary conditions of optimality for such systems are established and the optimal control is characterized via the adjoint variable. We also establish the uniqueness of optimal control in small time interval.
Strict dissipativity for discrete time discounted optimal control problems
Authors: Grüne Lars , Müller Matthias A. , Kellett Christopher M. , Weller Steven R.
Published: November 2020

The paradigm of discounting future costs is a common feature of economic applications of optimal control. In this paper, we provide several results for such discounted optimal control aimed at replicating the now well-known results in the standard, undiscounted, setting whereby (strict) dissipativity, turnpike properties, and near-optimality of closed-loop systems using model predictive control are essentially equivalent. To that end, we introduce a notion of discounted strict dissipativity and show that this implies various properties including the existence of available storage functions, required supply functions, and robustness of optimal equilibria. Additionally, for discount factors sufficiently close to one we demonstrate that strict dissipativity implies discounted strict dissipativity and that optimally controlled systems, derived from a discounted cost function, yield practically asymptotically stable equilibria. Several examples are provided throughout.
Introduction. Devenir orphelin : entre l’ordre des choses et le désordre des affects
Authors: Decout Maxime , Chaudier Stéphane
Published: November 2020

Au commencement, il y a une expérience, à la fois banale et tragique : devenir orphelin à l’âge adulte, à l’âge où il est justement normal de « perdre » ses parents. Mais ce qui s’inscrit dans le cours des choses n’est pas pour autant sans effet sur l’écrivain et sur son œuvre. Les textes réunis ici interrogent la productivité littéraire contemporaine de ces réalités existentielles à travers différentes générations d’auteurs (Perec, Derrida, Cixous ; Claude Louis-Combet, Jean Rouaud ; Philippe Vilain, Gwenaëlle Aubry, Lydia Flem, Anne Pauly…). L’expérience du deuil ouvre un espace d’écriture lié à un désir d’exploration où les formes littéraires se réinventent.
« Il n’y a pas d’âge pour se sentir orpheline » : Anne Pauly et l’écriture du deuil
Authors: Chaudier Stéphane
Published: November 2020

Avant que j’oublie d’Anne Pauly, prix Inter 2020, est la chronique d’un deuil. Mais pas seulement. C’est aussi le portrait d’un homme, d’un père, à la fois singulier et typique, un homme du peuple, un homme de sa génération, un homme désastreux et attachant. Mais c’est aussi et surtout l’analyse d’un processus subtil. Dans et par l’écriture se déploie la présence d’une âme — à la fois disparue et cependant irradiant de sa présence concrète un style voué à la susciter et se modelant à son image. Transmigration des âmes : le père n’a pas seulement fait sa fille orpheline, il l’a faite écrivaine.
Jean Rouaud. « La source noire » de l’écriture
Authors: Ducas Sylvie
Published: November 2020

Le deuil pour Jean Rouaud n’est pas qu’une catastrophe native, il est la condition première de la venue à l’écriture. L’expérience de la perte, en ce qu’elle est plurielle, itérative, inscrite dans une troublante « loi des séries », fonde le geste d’écrire et l’identité auctoriale dans ce désastre de la disparition de l’Autre avant soi, surtout celle du père mort prématurément lorsque son fils n’a que dix ans, mais aussi la mère et tous les aïeux du roman familial. Si la dynamique de l’œuvre roualdienne repose sur la périlleuse transmutation d’un être en deuil en un faire son deuil, son intérêt réside dans la façon dont elle achoppe sur l’impossibilité d’effacer totalement la mort. C’est cette thanatographie qui se conteste qu’on se propose ici d’étudier.
Riflessioni etiche sulla produzione e commercializzazione di organismi animali e vegetali geneticamente modificati
Authors: Bompiani A.
Published: November 2020

L’Autore esamina sotto l’aspetto etico il vasto dibattito in corso sulle biotecnologie, riferendosi in particolare agli organismi geneticamente modificati.

L’Autore approfondisce l’attuale concorso delle biotecnologie allo sviluppo umano, soffermandosi sull’eticità della “manipolazione” della natura vivente secondo una visione antropocentrica moderata, nella adeguata tutela della biodiversità ambientale e di un sufficiente grado di benessere animale.

L’articolo si sofferma poi sui “rischi”, che costituisce una delle principali domande etiche maggiormente avvertite dall’opinione pubblica.

Riconoscendo la difficoltà attuale di una valutazione epidemiologica precisa del “rischio” derivante dall’uso di alimenti geneticamente modificati attualmente commercializzati per la salute umana, lo studio si conclude affermando che è necessario: 1. Promuovere una maggiore informazione pubblica sui temi complessi delle biotecnologie e degli organismi geneticamente modificati; 2. Sostenere il criterio della valutazione scientifica del rischio, adottando peraltro il “principio di precauzione” (che tuttavia va meglio specificato in senso giuridico nelle applicazioni biotecnologiche); 3. Prevedere uno sviluppo di armonici rapporti fra i diversi settori interessati dalle biotecnologie (produttori, università per le attività di ricerche e formazione, consumatori, etc.), anche mediante l’assunzione dei criteri di massima “trasparenza” e di facoltà di scelta; 4. Assicurare a tutti i popoli della terra i benefici che possono derivare dalle applicazioni biotecnologiche.
Gram-negative infective endocarditis: a retrospective analysis of 10 years data on clinical spectrum, risk factor and outcome
Authors: Thomas Vineeth Varghese , Mishra Ajay Kumar , Jasmine Sudha , Sathyendra Sowmya
Published: November 2020

Infective endocarditis (IE) is a significant cause of morbidity and mortality. Underlying congenital heart disease and acquired valvular disease significantly increases the IE risk, which is still prevalent in developing countries. Gram-negative organism related IE prevalence appears to be rising with limited data on their presentation and outcomes. This study hopes to shed further light on this subject. This retrospective cross-sectional study occurred in a tertiary care center in South India. A retrospective cross-sectional study performed in a single tertiary care center in South India. All patients with IE from 2006 to 2016 were included in this study. The details of clinical presentation, laboratory investigations, clinical course, microbiology, and outcomes were obtained. Patients fulfilling the modified Duke's criteria and a culture-proven diagnosis of gram-negative IE were eligible for inclusion. A total of 27 patients were enrolled from Jan 2006 to Dec 2016, among whom 78% were male. Prior structural heart disease was common in our cohort (41%) with renal (55%) and embolic (51%) complications being the most common systemic complications. A comparison of mortality with survivors found that congenital and acquired structural heart disease had a higher risk of mortality. Non-fermenting GNB accounted for 52% of the cohort, with Pseudomonas accounting for 19%. E. coli was the most common bacilli isolated, constituting 37% of the cohort. Assessment of risk factors for adverse outcomes found that renal dysfunction and intravascular device were significant with multivariate-logarithmic analysis showing renal dysfunction as an independent risk factor. In-hospital mortality in this series was 30%. In conclusion, gram-negative IE was more prevalent among males. Underlying structural heart disease was the most common risk factor associated with the disease. Renal dysfunction and embolic complications were the most common complications in this cohort. E. coli and NFGNB accounted for 70% of the offending organisms. In-hospital mortality was similar to patients with IE secondary to common organisms. The presence of renal dysfunction was an independent risk factor for an adverse outcome.
Annotated checklist of the herpetofauna (Amphibia, Reptilia) of Lefkada Island (Ionian Islands, Greece)
Authors: Sindaco Roberto , Rossi Roberta
Published: November 2020

The island of Lefkada is a popular and easily accessible tourist destination; nevertheless, there is no comprehensive checklist of its interesting herpetofauna. Indeed, most records are old, scattered in different papers, and lacking precise locality data. In order to summarize the knowledge on the herpetofauna of the island, we critically reviewed literature, we looked for reliable records in the web and we carried out a field survey in May 2019. The herpetofauna of Lefkada amounts to 28 species (six amphibians and 22 reptiles). The occurrence of Testudo graeca on the island is considered unlikely, while an additional species, Testudo marginata, is here reported based on web sources. Among the species recorded on the island, 25 have been recently confirmed, two of them (Rana dalmatina and Anguis graeca) over a century. For three species (Lissotriton graecus, Chelonia mydas, and Podarcis tauricus) the last records date back to over 30 years ago.
The slow-flat-slow sequence in malignant vasovagal syncope
Authors: Vaksmann Guy , Bouzguenda Ivan , Lamblin Marie-Dominique
Published: November 2020

We present the electroencephalographic and electrocardiographic tracing obtained in an 8-year old boy who experienced malignant vasovagal syncope during the recording. This tracing illustrates the highly specific “slow-flat-slow” sequence described in cases of syncope induced by severe cerebral hypoperfusion.
Wet regeneration of waste artificial sand used in sand casting using chemical solutions
Authors: Ko Eun Yeong , Kim Kyeong Ho , Baek Jae Ho , Hwang Inseong , Lee Man Sig
Published: November 2020

Natural sand and organic binders have been the main materials used in sand casting. However, inorganic binders are used in novel casting technologies, and research on artificial sand as a substitute of natural sand has been conducted. Herein, the wet regeneration of waste artificial sand was performed using a sodium silicate binder. Acidic, neutral, and basic solutions were used for wet regeneration. The effects of binder removal and reusability of the regenerated sand were investigated by comparing the characteristics and strengths of the artificial and regenerated sand. It was demonstrated that the basic solution effectively removed the binder from the surface of the waste artificial sand. The Si-O-Si bond cleavage in the binder occurred due to the high concentration of hydroxide ions in the basic solution. The strength of the regenerated sand treated with the basic solution and that of the artificial sand were similar. Moreover, the strengths of regenerated sands treated with the acidic or neutral solutions were lower than that of artificial sand due to the presence of residual binder. These results indicated that the basic solution was suitable for removing the sodium silicate binder. The quality of the regenerated sand was similar to that of artificial sand.
A Study on Oxidation of Tetramethylammonium Hydroxide (TMAH) using UV/Persulfate
Authors: Choi Hyo-yeon , Pak Daewon
Published: November 2020

Objective : In order to efficiently remove TMAH from the wastewater generated by the TFT-LCD manufacturing process, the oxidation of TMAH was tested by applying an UV/persulfate. The optimum reaction conditions for high concentration TMAH oxidation were investigated by evaluating and comparing the removal efficiency according to the factors affecting TMAH oxidative degradation.Methods : In this study, TMAH was decomposed by sulfate radical (SO4-∙) and hydroxyl radical (OH∙) generated from persulfate activated by UV. Factors affecting on the treatment efficiency were try to be optimized by comparing and evaluating the removal efficiency depending on the initial pH, oxidant concentration, and initial TMAH concentration.Results and Discussion : Depending on initial pH (2, 7, 12), persulfate addition (0, 50, 100, 150, 200 mM), initial TMAH concentration (100, 300, 500, 700 mg/L) degradation rates of TMAH were compared. When UV/persulfate was applied, the removal efficiency of TMAH was close to 90% regardless of the initial pH and, at initial pH 12, was the highest with 89%. It was confirmed that the generation pattern of intermediate formed were different depending on the initial pH. When the oxidizing agent was not added, there was little change in TMAH concentration. The removal efficiency was highest when 100 mM persulfate was added. However the efficiency was rather low when 150 mM persulfate was added. When the initial TMAH concentration was 100 mg/L, it was decreased within 150 minutes. As the initial concentration increased, the removal efficiency and reaction rate constant decreased.Conclusions : As a results, during the oxidation of 750 mg/L TMAH by using UV/persulfate, the removal efficiency was highest with initial pH 12 and 100 mM of persulfate addition.
O “ser autor” na prática do jornalismo diversional
Authors: De Assis Francisco
Published: November 2020

O artigo discute o significado de autoria na prática do chamado jornalismo diversional, que se destaca por sua função de divertir – ou seja, pelo “prazer estético” proporcionado a audiências potenciais –, cumprida com o uso de recursos expressivos próprios da literatura, os quais são responsáveis por equiparar narrativas do cotidiano a obras ficcionais. Apoiando-nos em pesquisa bibliográfica e em observações baseadas nos relatos de jornalistas notadamente cultivadores do gênero, que nos concederam entrevista, discutimos que, no bojo a que nos direcionamos, autoria vai muito além da assinatura de um texto ou, mesmo, da possibilidade de fazer reportagem com traços literários. Ser autor, nesse âmbito, é ter habilidades e condições para desenvolver um estilo próprio – em geral, notado por outros –, sem deixar de atender a exigências fundamentais da atividade.
De Caligari à Rainha Má
Authors: Gonçalves Gamba Junior Nilton , Gaio Silveira de Senna Marcelus
Published: November 2020

Este artigo está inserido em um processo de pesquisa de doutorado As idades do Expressionismo – criação de estilo e atmosfera em filmes de animação, que tem sua origem no questionamento sobre as possíveis influências que o cinema de animação recebeu do movimento expressionista – mais particularmente de suas vertentes nas artes plásticas e no cinema. O cinema de animação teria, portanto, além das influências de meios como, por exemplo, os cartoons, os livros infantis e o próprio cinema live action, a influência específica do Expressionismo Alemão na constituição de sua linguagem. Dentre as várias possibilidades de análise, adotamos aqui uma abordagem histórica e formal, para identificar um dos principais elementos expressivos formais do Expressionismo Alemão – a iluminação em claro-escuro –, e, em seguida, verificar a ocorrência deste elemento expressivo formal no filme Branca de Neve e os sete anões.
Produzindo animação
Authors: Cipiniuk Alberto , Freitas Ribeiro Leonardo
Published: November 2020

Este artigo apresenta uma análise sobre o trabalho do profissional especializado em animação, a partir de uma perspectiva da animação como prática social. Do mesmo modo, procura esclarecer a natureza dessa prática e entender as causas da noção de artista como gênio prevalecer dentro de um universo de saberes e procedimentos coletivos, tal como o cinema de animação. Usamos como ponto de partida de nossa análise o trabalho sobre biografias de artistas, de Kris e Kurz, a noção de “mundo” da arte, de Becker, em diálogo com a noção de “campo”, de Bourdieu e os conceitos de arte e ideologia formulados por Wolff.
Governo eletrônico, democracia digital e comunicação pública
Authors: Da Silva Vanzini Katia Viviane , Rothberg Danilo
Published: November 2020

Este artigo descreve resultados de pesquisa que empreendeu uma análise comparativa das páginas web dos tribunais superiores do Poder Judiciário no Brasil — Supremo Tribunal Federal (STF), Superior Tribunal de Justiça (STJ), Tribunal Superior Eleitoral (TSE), Tribunal Superior do Trabalho (TST) e Supremo Tribunal Militar (STM) — e de seus órgãos fiscalizadores — Conselho Nacional de Justiça (CNJ), Conselho da Justiça Federal (CJF) e Conselho Superior da Justiça do Trabalho (CSJT) com o objetivo de produzir um diagnóstico da qualidade da exploração das tecnologias. A metodologia envolveu análise de conteúdo em quatro categorias: informações institucionais; transparência; serviços; e interatividade. Os resultados indicam que os portais apresentaram desempenho satisfatório nas categorias de informações institucionais (87% das páginas web analisadas contêm informações relacionadas), transparência (78%) e serviços (74%), mas nota-se a insuficiência da exploração de recursos de interatividade (39% das páginas contêm mecanismos de input dos usuários). Estes dados são interpretados à luz de recomendações de organismos internacionais e pesquisas na área.
Transposición didáctica y educación deportiva en la Educación Física del Sistema Educativo
Authors: Sarni Muñiz Mariana , Beer David
Published: November 2020

El objetivo del texto es aportar insumos que permitan poner a discusión los conceptos de transposición didáctica y de educación deportiva en la Educación Física del Sistema Educativo. El primero, la trasposición didáctica, puede llevar a una interpretación que considera, de manera reduccionista, que el campo de lo escolar es una suerte de molde en donde el saber sabio ha de verter sus conocimientos, que no son otra cosa que “los conocimientos en estado prístino”, ignorando supinamente las condiciones epistemológicas y sociales que posibilitan y condicionan su aparición, como así también los propósitos y necesidades peculiares y específicas de cada campo. La Educación Física, luego del paso por las influencias biomédicas y/o militaristas, parece haber adoptado al deporte como el saber sabio, organizando de esta manera sus prácticas; este deporte, parece además, fuertemente influenciado por una lógica claramente dependiente de su égida. Si la escuela se propone generar procesos de solidaridad, de grupalidad y cooperación por sobre las actitudes individualistas, meritocráticas e hipercompetitivas, y superar su naturalizada socialización hacia la búsqueda de procesos definitivamente transformadores, deberá plantearse cuáles son las situaciones motrices de las que valerse y el carácter pedagógico y emancipatorio de su propuesta. Esto no implica desechar el deporte; se trata de apropiarse de él, de resignificarlo y subvertirlo a la medida de los intereses del campo educativo y no de manera crítica y obsecuente, y de esta forma proponer prácticas escolares que conduzcan procesos deliberados de educación deportiva.
Controversies in Sepsis Management—What is the Way Forward?
Authors: Lo Alvin HY , Kee Adrian CL , Li Andrew , Rubulotta Francesca
Published: November 2020

Sepsis is life-threatening and might potentially progress from dysregulation to severe organ dysfunction. It is recognised by the World Health Organisation as a global health priority. The mortality rate for sepsis has decreased in many countries, and this is credited to the earlier recognition and treatment of this complex syndrome. In 2002, the Surviving Sepsis Campaign was launched, and there have been several revisions to the sepsis recommendations therefrom. The latest sepsis guidelines focus on viral as well as bacterial infections, and advise that initiating resuscitation and management should take place within one hour from when sepsis is initially suspected. Numerous studies and guidelines pertaining to sepsis management have been published over the past 2 decades. The use of novel therapies and alternative adjunctive therapies has tremendous potential in sepsis management. Debates amongst intensivists exist with the creation of updated sepsis guidelines and advances in treatment. The present review article provides both a summary and recommendations based on the latest clinical evidence and controversies around sepsis management. Key words: Critical Care Medicine, Intensive Care Medicine, Respiratory Medicine, Sepsis, Sepsis Bundles, Sepsis Management
DORSCON Orange: An Approach to Challenges in a Busy Antenatal Diagnostic Centre in the Midst of a Global Pandemic
Authors: Sim Wen Shan , Tan June VK , Zhang Valencia RY , Chong Glenda SL , Ku Chee Wai , Tan Kok Hian , Tan Hak Koon , Yeo George SH
Published: November 2020

The WHO declared the coronavirus disease 2019 (COVID-19) a global pandemic on 11 March 2020. Lessons from SARS epidemic led Singapore to develop stringent infection control protocols in preparation for future pandemics. However, unlike SARS, COVID-19 appears to be more transmissible and is predicted to continue for longer. As of 14 June 2020, there have been 40,197 positive cases with 26 deaths in Singapore, and KK Women’s and Children’s Hospital (KKH) has managed a total of 73 cases. Obstetrics ultrasound is an indispensable medical service and must continue to operate during a pandemic. A key balance must be struck between keeping patients and healthcare workers safe while being able to provide quality and prompt obstetric care. Our Antenatal Diagnostic Centre (ADC) in KKH developed new strategies to adapt to the pandemic when the national Disease Outbreak Response System Condition (DORSCON) was raised from yellow to orange on 7 February 2020. In this paper, we discuss our clinical workflow to reduce the risk of transmission amongst patients and staff while minimising disruption to our services.