bluuebunny/crossref_metadata_2025 huggingface dataset:
Eksistensi Paralegal dalam Meminimalisir Kekerasan Terhadap Perempuan di Desa Tuwed Kabupaten Jembrana
Authors: Sugiartha I Nyoman Gede , Swetasoma Cokorde Gede
Published: November 2022

Esistensi paralegal dalam meningkatkan kesadaran hukum masyarakat telah banyak diteliti. Salah satu peran penting paralegal di Bali khususnya di Desa Tuwed kecamatan Melaya Kabupaten, Jembrana adalah meminimalisir kekerasan terhadap perempuan yang masih dijumpai  Bali  yang  terkenal  dengan  menjungjung  tinggi  garis  keturunan patrilinial dimana adanya anggapan bahwa kedudukan laki-laki lebih tinggi dibandingkan perempuan.  Hal  tersebut  terjadi  diakibatkan  kurangnya  pengetahuan  tentang hukum terutama bagi masyarakat miskin dan marginal. Setelah lahirnya paralegal sebagai implementasi dari Undang-Undang Nomor 16 Tahun 2011 Tentang Bantuan Hukum sangatlah menarik untuk diteliti dengan kaitannya dengan kekerasan terhadap perempuan. Permasalahannya adalah Bagaimana eksistensi paralegal dalam meminimalisir kasus kekerasan terhadap perempuan di Desa Tuwed Kecamatan Melaya Kabupaten Jembrana  dan Bagaimana upaya paralegal dalam meningkatkan kesadaran hukum mencegah kekerasan terhadap perempuan di Kabupaten Jembrana. Dalam penelitian ini penulis menggunakan metode penelitian empiris dengan pendekatan studi kasus dalam meneliti keberadaan  paralegal dalam mecegah kekerasan terhadap perempuan telah diatur dalam Undang – Undang Bantuan Hukum Nomor 16 Tahun 2011 tentang Bantuan Hukum. Hasil penelitian ini menujukan bahwa Eksistensi paralegal dalam mencegah kekerasan terhadap perempuan di Desa Tuwed Kabupaten Jembrana berjalan efektif, dikarenakan telah terjadinya peningkatan kesadaran hukum dari masyarakat dan sosialisasi   tentang   paralegal   dan kekerasan terhadap perempuan kepada masyarakat Kabupaten Jembrana.
ANALISIS KONDISI FUNGSIONAL RUAS JALAN JENU-MERAKURAK DENGAN MENGGUNAKAN METODE PSI DAN RCI SERTA PREDIKSI SISA UMUR PERKERASAN JALAN (REMAINING LIFE)
Authors: Sugiyanto  , Arifin Nur Ahmad
Published: November 2022

Penelitian ini dilaksanakan dengan tujuan untuk menganalisa kondisi fungsional jalan Jenu-Merak Urak. Pada ruas jalan dengan konstruksi menggunakan perkerasan lentur (jalan aspal) dan memiliki panjang 5.3 kilometer atau 3.29 mil, analisa didasarkan pada nilai kerataan jalan atau IRI (international roughness index) diperoleh pada pengamatan jalan tersebut. Parameter yang digunakan berupa indeks-indeks yang terkait dengan tingkat keyamanan/kinerja jalan (riding quality) dan perkiraan sisa umur layanan jalan. Hasil penelitian ini mendapatkan hasil analisis fungsional jalan berdasarkan kondisi permukaan jalan (road condition index) sebesar 7.75 dapat dinyatakan kondisi permukaan jalan yang dianalisa tergolong sangat baik dan umumya rata. Demikian juga, hasil analisis fungsional jalan berdasarkan kondisi pelayanan jalan (present serviceability index) sebesar 4.03 dapat dinyatakan kondisi fungsi pelayanan jalan yang dianalisa tergolong baik. Berdasarkan data peningkatan lalu lintas aktual (3.05%/tahun) dibanding dengan rencana (2.7%/tahun) mengakibatkan prediksi sisa umur perkerasan (remaining life) jalan yang dianalisa, umur rencana jalan berakhir 3 (tiga) tahun lebih cepat dari umur yang direncanakan. Hasil analisa yang didapatkan pada penelitian ini dapat membuktikan terjadi korelasi dan tidak berdiri sendiri antara hasil analisis kondisi permukaan jalan yang tergolong baik dan umumnya rata akan menghasilkan kondisi pelayanan jalan yang tergolong baik juga.
Alternative Settlement of Dispute Results for the Election of Village Head to Realize Democracy in South Buton
Authors: Indah Kusuma Dewi  , Luh Putu Sudini  , Hardin  , Faais Mufaasir Ramadhan
Published: November 2022

The emergence of prolonged Village Head Election Conflicts due to fanaticism and the harsh confrontation of supporters of the village head candidates who face to face fight for the victory of their respective candidates. Sometimes they even forget the value of democracy and undermine the ethical values ​​that have been embedded in village communities. The purpose of this study was to determine the resolution of the dispute over the election results of the Lawela Village Head in realizing democracy in South Buton and to find out the legal consequences of the South Buton Regent's decision on the cancellation of the results of the Lawela Village Head election, South Buton Regency. The method used in this research is normative juridical. The stages of the research method are preparation and administration, inventory of relevant laws and regulations, research, analysis of research results, preparation of research reports and Focus Group Discussion. Based on the above explanation, the legal consequence of the South Buton Regent's Decree Number 341 of 2019 concerning the Dispute Resolution of the Election Results of the Lawela Village Head, Batauga District, South Buton Regency in 2019 is that the results of the Lawela Village Head election in the Lawela Village Head Election become non-binding from the moment it is canceled or fixed. The legal consequences for the elected Village Head candidate in Lawela Village are being canceled as the elected Village Head candidate or as Lawela Village Head for the 2019-2015 periods and/or as the winner who has succeeded in obtaining the most votes based on the determination of the Lawela Village Head Election Committee in 2019.
The Impact of Tourism Industry Development In Relation to Violations of Utilisation of Cliff Borders by Tourism Entrepreneurs
Authors: Luh Putu Suryani  , Ida Ayu Putu Widiati  , Indah Permatasari
Published: November 2022

It is undeniable that the development of the tourism industry can have both positive and negative impacts on the economic, socio-cultural and environmental sectors. In the context of Bali, development of tourism industry will certainly have impacts towards the development of tourism supporting facilities in the form of hotels, restaurants, entertainment and recreation and so on. The aims of this research are to examine the impacts of the development of the tourism industry in relation to violations of the utilisation of cliff borders by tourism entrepreneurs and the one that involves reconstruction of legal norms in accordance with the concept of sustainable tourism development. The research takes the type of empirical legal research. The results show that the existence of tourism supporting facilities on the cliff borders in turn brings about negative impacts on the environment. As a consequence, legal reconstruction is urgently needed by adding more detailed justifications related to the regulations regarding the cliff border areas. The legal reconstruction in question can be done by adding the provisions of Articles in Provincial and Regencial or Municipal Regulations, or can be executed through preparation or reconstruction of additional provisions of Articles in the Regencial or Municipal Spatial Detail Plan or through zoning regulations based on sustainable tourism development.
Akuntabilitas Pengelolaan Dana Sosial LPD Berlandaskan Budaya Tri Hita Karana
Authors: Indriyani Ni Made Vita , Putra I Wayan Gde Yogiswara Darma
Published: November 2022

Lembaga Perkreditan Desa yang selanjutnya disingkat dengan ( LPD ) yaitu salah satu lembaga yang dibentuk oleh Desa Pakraman yang berfungsi menjalankan dan mengelola sistem keuangan desa serta berupaya dalam memajukan kesejahteraan masyarakat desa dan memenuhikepentinganmasyarakat desa adat pakraman itu sendiri. Dalam melaksanakan kegiatan utamanya yaitu menyalurkan dan menghimpun dana, LPD Susut Kaja dan LPD Desa Pekraman Kebon Bangli juga melaksanakan akuntabilitasnya yang berlandaskan atas budaya tri hita karana. Dalam LPD, istilah CSR memang tidak digunakan, namun konsep dalam pengelolaan dana sosialnya memiliki konsep serupa dengan CSR. Hasil yang diperoleh pada penelitian ini bahwa pengelolaan dana sosial sebesar 5% dari laba berjalan pada satu tahun periode dikelola sesuai dengan budaya tri hita karana. Dimana, dari 5% laba berjalan tersebut digunakan untuk mengharmoniskan hubungan dengan Tuhan melalui yadnya berupa dana punia, mengharmoniskan hubungan dengan manusia berupa bantuan sembako maupun pendidikan serta mengharmoniskan hubungan dengan lingkungan berupa penyediaan sarana dan prasarana untuk menjaga kelestarian lingkungan.
Pengaruh Produk Domestik Regional Bruto (PDRB) dan Tingkat Inflasi Terhadap Jumlah Deposito Berjangka Pada Bank Umum di Provinsi Bali Periode 2014-2019
Authors: Padmi Ni Luh Made Sri , Purnami A. A. Sri , Azis Ita Silvia Azita
Published: November 2022

Penelitian ini berjudul Pengaruh Produk Domestik Regional Bruto (PDRB) Dan Tingkat Infalsi Terhadap Jumlah Deposito Berjangka Pada Bank Umum Di Provinsi Bali Periode 2014-2019. dengan menggunakan data sekunder yang diperoleh dari laporan Bank Indonesia dan Badan Pusat Statistik Provinsi Bali. Data yang diolah merupakan data runtun waktu (time series) secara triwulanan. Agar mengetahui Pengaruh PDRB, Tingkat Inflasi Terhadap Jumlah Deposito Berjangka, baik secara serempak maupun parsial adalah tujuan dilakunnya penelitian ini. Regresi linier berganda merupakan teknik analisis yang digunakan. Bank Umum di Provinsi Bali menjadi objek penelitian. Pengujian dari uji F memberikan hasil, bahwa PDRB dan Tingkat Inflasi secara bersama-sama(serempak), memberikan pengaruh yang signifikan terhadap Jumlah Deposito Berjangka. Pengujian dari hasil uji t pada variabel PDRB mempunyai pengaruh positif dan signifikan terhadap jumlah deposito berjangka pada Bank Umum di Provinsi Bali, pada variabel tingkat inflasi mempunyai pengaruh negatif dan signifikan terhadap jumlah deposito berjngka pada Bank Umum di Provinsi Bali.
Faktor-Faktor yang Dominan Mempengaruhi Permintaan pada Distro Kota Denpasar
Authors: Deyan Ni Putu Rasrita , Purnami A. A. Sri , Wulandari I Gusti Ayu Athina
Published: November 2022

Distro adalah dunia model pakaian yang diproduksi sendiri, merek dan juga mengeluarkan desain sendiri dan juga pemasarannya sendiri. Penelitian ini mendalami faktor kuatnya permintaan moderat di tingkat Kota Denpasar. Penelitian ini menjajakan data primer dengan teknik analisis faktor ekspolatori. Penelitian ini menjajakan faktor demand yang mempengaruhi distro-distro di Kota Denpasar secara keseluruhan sebagai faktor utama adalah future state terdiri dari satu variabel aproksimasi dan arousal dari tepat empat variabel. Melihat kajian faktor-faktor yang mempengaruhi demand di Kota Denpasar menjadi faktor peramalan keadaan dimasa yang akan datang berupa salah satu variabel dan faktor yang berada pada posisi kedua adalah perkiraan dan selera.
The Moderating Effect of Academic Self-efficacy on the Relationship between Self-directed Learning Ability and Learning Performance in Online College English Class
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Jeong So Young , Uhm Chul Joo
Published: November 2022

Objectives This study aimed to examine the structural relationships among self-directed learning, self-directed English learning ability, learning satisfaction and academic achievement, and to analyze the differences in learning performance according to academic self-efficacy in online college English classes. Methods A web-based survey was conducted on 172 students who took English classes in the first and second semesters of 2021 at N University. The data were analyzed with SPSS 23.0 and AMOS 21.0. For the moderating effect of students' academic self-efficacy, a multi-group analysis of structural equations was used. Results The results were as follows: First, self-directed learning had a positive effect on the self-directed English learning ability. Second, the two factors, self-directed learning ability and self-directed English learning ability, had a positive effect on learning satisfaction, but only self-directed English learning ability had a significant effect on academic achievement. Third, a multi-group analysis for the moderating effect verified that students with high academic efficacy showed a significant effect on academic achievement. Conclusions It is meaningful that the effect of autonomous learning of college students on self-directed learning ability of English subjects was statistically verified. Based on the results of the study, it is suggested that the method to improve the self-directedness and academic self-efficacy of learners should be sought properly.
RELAÇÕES LINFÓCITO/MONÓCITO, NEUTRÓFILO/LINFÓCITO, PLAQUETA/LINFÓCITO E TOXICIDADES EM PACIENTES DIAGNOSTICADOS COM CÂNCER DE CABEÇA E PESCOÇO
Authors: Bender Simsen Camila Cristina , Dexheimer Geórgia Muccillo
Published: November 2022

O câncer de cabeça de pescoço é o terceiro mais incidente no Brasil, afetando em sua maioria o sexo masculino. O prognóstico dos pacientes acometidos por tumores é associado com marcadores de progressão tumoral e apresenta relação com o sistema imunológico e suas respostas. Dentre os marcadores, as relações entre monócitos e linfócitos (RLM), neutrófilos e linfócitos (RNL) e entre linfócitos e plaquetas (RLP) vêm sendo apontadas como importantes indicadores tumorais e relacionados com a qualidade de vida. O presente estudo teve como objetivo avaliar as relações entre monócitos e linfócitos, neutrófilos e linfócitos e entre linfócitos e plaquetas como marcadores no prognóstico e de toxicidade precoce em pacientes com câncer de cabeça e pescoço de um hospital de médio porte da região do Vale do Taquari/RS. A pesquisa foi retroativa assim, analisando as evoluções médicas dos pacientes do estudo, disponíveis no programa Tasy do hospital. Os dados foram obtidos através da análise de hemogramas no período de janeiro de 2018 até o momento da coleta de dados em 2020. Dados como idade, sexo e data de início do tratamento foram levadas em conta, além de toxicidades agudas. Foram analisados um total de 197 prontuários, sendo que somente 10 puderam ser incluídos no estudo. As relações leucocitárias não apresentaram diferenças significativas, porém, alguns dos pacientes apresentaram diminuição da RNL e da RLP e aumento da RLM.
ANÁLISE DA ROTULAGEM DE ALIMENTOS EMBALADOS E COM DECLARAÇÃO DE INFORMAÇÃO NUTRICIONAL COMPLEMENTAR
Authors: Boff Tainá , Fassina Patricia
Published: November 2022

A rotulagem nutricional contribui de forma essencial para a escolha adequada dos alimentos, representando os produtos industrializados com o propósito de determinar a composição dos alimentos e as informações gerais, sendo de extrema importância para uma alimentação saudável. O presente estudo teve por objetivo analisar a rotulagem dos alimentos embalados e com declaração de Informação Nutricional Complementar (INC) em relação às legislações vigentes. Trata-se de uma pesquisa de caráter transversal, quantitativo, descritivo, exploratório e observacional. O estudo foi desenvolvido no período maio de 2022. Os critérios para análise foram rotulagem de alimentos embalados e com declarações de INC em relação a 13 alegações pré definidas quanto ao conteúdo absoluto de valor energético, açúcares, gorduras trans, ácidos graxos ômega 3, colesterol, sódio, proteínas, fibra alimentar, cálcio, ferro, zinco, vitamina A e vitamina D, de acordo com as Resoluções de Diretoria Colegiada (RDCs) 259/2002, 359/2003, 360/2003, 54/2012, e 26/2015 junto a Lei nº 10.674/03 da Agência Nacional de Vigilância Sanitária (ANVISA). A maioria dos rótulos de alimentos analisados e comercializados estavam adequados à legislação brasileira. As inconformidades verificadas foram relacionadas à porção em desacordo com a RDC 359/2003 em quatro (n=4) rotulagens e nas cifras decimais dos valores de percentual de valor diário (% VD) da rotulagem nutricional perante a RDC 360/2003 em duas (n=2) rotulagens. Das 13 alegações de propriedades nutricionais avaliadas frente a RDC 54/2012 foram encontradas irregularidades para INC de alimentos com os atributos “não contém açúcares” (n=3), “fonte de proteínas” (n=2), “muito baixo em sódio” (n=1) e “fonte de fibras” (n =1) rotulagens. Apesar de a maior parte dos rótulos de alimentos analisados estarem adequados à legislação, a incidência de não conformidades indica que ainda há falta de conhecimento e entendimento da legislação brasileira sobre a rotulagem por parte de alguns fabricantes para que essas embalagens prestem melhores informações aos consumidores e cumpram com a legislação vigente.
REFLEXO DO ATENDIMENTO ONLINE NA SAÚDE MENTAL DE PSICÓLOGOS CLÍNICOS: UM GRUPO FOCAL
Authors: Grosselli Eduarda , Cavanus Gabriel , Diehl Liciane
Published: November 2022

Com o isolamento social imposto pela pandemia da Covid-19, muitos profissionais tiveram suas condições de trabalho adaptadas, dentre eles, os psicólogos. Este estudo, de abordagem qualitativa, busca descrever as possibilidades e desafios do trabalho de psicólogos clínicos durante a pandemia da Covid-19. Para esse fim, realizou-se um grupo focal com cinco psicólogos e psicólogas que adaptaram as condições de atendimento psicológico ao formato online. Posteriormente, os dados foram analisados por meio da análise de conteúdo. Foi possível constatar que o atendimento psicológico online foi uma alternativa indispensável para a prevenção de sofrimento mental e promoção de saúde. Identificou-se, ainda, que essa modalidade de trabalho necessita de um olhar atento no que diz respeito aos Conselhos de Psicologia, ao nível Federal e Regional, de modo que os profissionais e futuros profissionais da área possam ter conhecimento dessa forma de atuação profissional e de seus princípios éticos.
Salvia officinalis-based green-mediated vanadium nanoparticles: Describing a modern chemotherapeutic drug for the treatment of colorectal carcinoma
Authors: Xu Ruimin
Published: November 2022

In this study, vanadium nanoparticles were green synthesized using the
aqueous extract of Salvia officinalis. Different techniques such as
FE-SEM, XRD, FT-IR, and EDS analysis were used to characterize
VNPs@Salvia officinalis. A 25.6 nm was obtained for the crystal size of
the vanadium nanoparticles using XRD analysis. The FE-SEM images show a
spherical morphology for VNPs@Salvia officinalis with the range size of
11.28 to 40.74 for the synthetic nanoparticles. In the antioxidant test,
the IC50 of VNPs@Salvia officinalis and BHT against DPPH free radicals
were 300 and 265 µg/mL, respectively. For anticancer activity evaluation
the treated cells with VNPs@Salvia officinalis were assessed by MTT
assay for 48h about the cytotoxicity and anti-colorectal cancer
properties on normal (HUVEC) and colorectal cancer cell lines i.e.,
Caco-2, COLO 320, DLD-1‎, HCT-15‎, HCT-116‎, and HT-29. The IC50 of
VNPs@Salvia officinalis were 213, 210, 297, 204, 160, and 125 µg/mL
against Caco-2, COLO 320, DLD-1‎, HCT-15‎, HCT-116‎, and HT-29 cell
lines, respectively. The viability of malignant colorectal cell lines
reduced dose-dependently in the presence of VNPs@Salvia officinalis. It
appears that the anti-colorectal cancer effect of VNPs@Salvia
officinalis is due to their antioxidant effects.
A Microwave Limiter with Non-reciprocal Limiting Threshold
Authors: Shen Jian , Liu Jibin , Lin Mingtuan , Wu Zhangfeng , Deng Shixiong
Published: November 2022

A novel microwave limiter with non-reciprocal limiting threshold is
proposed in this paper to protect the transceiver switch or the
transmitter. The directivity of the directional coupler is utilized to
make the power of the received signal input to the detection circuit
larger than that of the transmitted signal, thereby the detection
circuit provides different DC bias voltage to the limiter circuit and
changes the threshold level of the limiter diode. The test results show
that this limiter has a threshold level of 35 dBm for the transmitted
signal and 17 dBm for the received signal, which has a non-reciprocal
limiting threshold for high-power signals input in both directions.
Education and Economic Growth in the Economic Community of West African States (ECOWAS)
Authors: Awolusi Olawumi Dele
Published: November 2022

The declining level of economic growth in the Economic Community of West African States (ECOWAS) has been attributed to the poor level of educational development in the bloc. Consequently, this study aims to assess the effect of primary, secondary and tertiary educational development on economic growth in the ECOWAS bloc. The study adopted an extended literature review/ desktop research methodology to address three research questions. Findings based on the extended literature review indicated negative and insignificant relationships between primary educational development and economic growth in the ECOWAS bloc. Secondly, findings also established largely positive relationships between secondary educational development and economic growth in the bloc. Lastly, the relationship between tertiary educational development and economic growth was largely mixed in the ECOWAS bloc. The three specific conclusions were, therefore, validated by both the institutional fitness theory and the new theory of growth. Consequently, to improve the contributions of primary, secondary and tertiary educational development to economic growth in the ECOWAS bloc, the present study recommends the promotion of enhanced social programs, integration of existing policies and creation of societal culture executed within a sound institutional framework, reduction in unemployment, regional disparities, defining the active role of non-governmental organizations (NGOs) and other independent institutions, as well as even distribution of political and financial power, especially in Nigeria, the largest country in the bloc.
Questionnaire-Based Polyexposure Assessment Outperforms Polygenic Scores for Classification of Type 2 Diabetes in a Multiancestry Cohort
Authors: Akhtari Farida S. , Lloyd Dillon , Burkholder Adam , Tong Xiaoran , House John S. , Lee Eunice Y. , Buse John , Schurman Shepherd H. , Fargo David C. , Schmitt Charles P. , Hall Janet , Motsinger-Reif Alison A.
Published: November 2022

OBJECTIVE

Environmental exposures may have greater predictive power for type 2 diabetes than polygenic scores (PGS). Studies examining environmental risk factors, however, have included only individuals with European ancestry, limiting the applicability of results. We conducted an exposome-wide association study in the multiancestry Personalized Environment and Genes Study to assess the effects of environmental factors on type 2 diabetes.

RESEARCH DESIGN AND METHODS

Using logistic regression for single-exposure analysis, we identified exposures associated with type 2 diabetes, adjusting for age, BMI, household income, and self-reported sex and race. To compare cumulative genetic and environmental effects, we computed an overall clinical score (OCS) as a weighted sum of BMI and prediabetes, hypertension, and high cholesterol status and a polyexposure score (PXS) as a weighted sum of 13 environmental variables. Using UK Biobank data, we developed a multiancestry PGS and calculated it for participants.

RESULTS

We found 76 significant associations with type 2 diabetes, including novel associations of asbestos and coal dust exposure. OCS, PXS, and PGS were significantly associated with type 2 diabetes. PXS had moderate power to determine associations, with larger effect size and greater power and reclassification improvement than PGS. For all scores, the results differed by race.

CONCLUSIONS

Our findings in a multiancestry cohort elucidate how type 2 diabetes odds can be attributed to clinical, genetic, and environmental factors and emphasize the need for exposome data in disease-risk association studies. Race-based differences in predictive scores highlight the need for genetic and exposome-wide studies in diverse populations.
Long-term Exposure to Ambient PM2.5 and Its Components Associated With Diabetes: Evidence From a Large Population-Based Cohort From China
Authors: Li Sicheng , Guo Bing , Jiang Ye , Wang Xing , Chen Lin , Wang Xue , Chen Ting , Yang La , Silang Yangzong , Hong Feng , Yin Jianzhong , Lin Hualiang , Zhao Xing
Published: November 2022

OBJECTIVE

Association between particulate matter with aerodynamic diameters ≤2.5 μm (PM2.5) components and diabetes remains unclear. We therefore aimed to investigate the associations of long-term exposure to PM2.5 components with diabetes.

RESEARCH DESIGN AND METHODS

This study included 69,210 adults with no history of diabetes from a large-scale epidemiologic survey in Southwest China from 2018 to 2019. The annual average concentrations of PM2.5 and its components were estimated using satellite remote sensing and chemical transport modeling. Diabetes was identified as fasting plasma glucose ≥7.0 mmol/L (126 mg/dL) or hemoglobin A1c ≥48 mmol/mol (6.5%). The logistic regression model and weighted quantile sum method were used to estimate the associations of single and joint exposure to PM2.5 and its components with diabetes, respectively.

RESULTS

Per-SD increases in the 3-year average concentrations of PM2.5 (odds ratio [OR] 1.08, 95% CI 1.01–1.15), black carbon (BC; 1.07, 1.01–1.15), ammonium (1.07, 1.00–1.14), nitrate (1.08, 1.01–1.16), organic matter (OM; 1.09, 1.02–1.16), and soil particles (SOIL; 1.09, 1.02–1.17) were positively associated with diabetes. The associations were stronger in those ≥65 years. Joint exposure to PM2.5 and its components was positively associated with diabetes (OR 1.04, 95% CI 1.01–1.07). The estimated weight of OM was the largest among PM2.5 and its components.

CONCLUSIONS

Long-term exposure to BC, nitrate, ammonium, OM, and SOIL is positively associated with diabetes. Moreover, OM might be the most responsible for the relationship between PM2.5 and diabetes. This study adds to the evidence of a PM2.5-diabetes association and suggests controlling sources of OM to curb the burden of PM2.5-related diabetes.
Cost-effectiveness of a collaborative care model among patients with type 2 diabetes and depression in India
Authors: Emmert-Fees Karl M. F. , Laxy Michael , Patel Shivani A. , Singh Kavita , Poongothai Subramani , Mohan Viswanathan , Chwastiak Lydia , Narayan K M  Venkat , SAGAR RAJESH , Sosale Aravind , Anjana Ranjit Mohan , Sridhar Gumpeny R. , Tandon Nikhil , Ali Mohammed K
Published: November 2022

  

Objective

To assess the cost-effectiveness of collaborative versus usual care in adults with poorly-controlled type 2 diabetes and depression in India.

Research Design and Methods

We performed a within-trial cost-effectiveness analysis of a 24-month parallel, open-label, pragmatic randomized clinical trial at four urban clinics in India from multipayer and societal perspectives. The trial randomized 404 patients with poorly-controlled type 2 diabetes (HbA1c≥8.0% or systolic BP≥140mmHg or LDL-c≥130mg/dl) and depressive symptoms (PHQ-9≥10) to collaborative care (support from non-physician care coordinators, electronic registers, and specialist-supported case review) for 12 months, followed by 12 months usual care or 24 months usual care. We calculated incremental cost-effectiveness ratios (ICER) in Indian rupees (INR) and international dollars (Int’l) and the probability of cost-effectiveness using quality-adjusted life years (QALYs) and depression-free days (DFDs).

Results

From a multipayer perspective, collaborative care costed additional INR309,558 (Int’l-$15,344) per QALY and additional INR290.2 (Int’l-$14.4) per DFD gained compared to usual care. The probability of cost-effectiveness was 56.4% using a willingness-to-pay of INR336,000 (Int’l-$16,654) per QALY (~3-times per-capita GDP). The willingness-to-pay per DFD to achieve a probability of cost-effectiveness >95% was INR401.6 (Int’l-$ 19.9). From a societal perspective, cost-effectiveness was marginally lower. In sensitivity analyses, integrating collaborative care in clinical workflows reduced incremental costs by ~47% (ICER: 162,689/QALY; cost-effectiveness probability: 89.4%) but cost-effectiveness decreased when adjusting for baseline values.

Conclusions

Collaborative care for patients with type 2 diabetes and depression in urban India can be cost-effective, especially when integrated in clinical workflows. Long-term cost-effectiveness might be more favorable. Scalability across lower- and middle-income country settings depends on heterogeneous contextual factors. 
Deficits and Disparities in Early Uptake of GLP-1 Receptor Agonists and SGLT2 Inhibitors among Medicare-insured Adults Following a New Diagnosis of Cardiovascular Disease or Heart Failure
Authors: Cromer Sara J. , Lauffenburger Julie C. , Levin Raisa , Patorno Elisabetta
Published: November 2022

  

Objective: To examine the association of race/ethnicity and socioeconomic deprivation with initiation of guideline-recommended diabetes medications with cardiovascular benefit (glucagon-like peptide-1 receptor agonists (GLP1-RA) and sodium-glucose co-transporter-2 inhibitors (SGLT2i)) among older adults with type 2 diabetes (T2D) and either incident atherosclerotic cardiovascular disease (ASCVD) or congestive heart failure (CHF).

Research Design and Methods: Using Medicare data (2016-2019), we identified 4,057,725 individuals over age 65 with T2D and either incident ASCVD or CHF. We estimated incidence rates (IR) and hazard ratios (HR) of GLP1-RA or SGLT2i initiation within 180 days by race/ethnicity and zip code-level Social Deprivation Index (SDI) using adjusted Cox proportional hazards models. 

Results: IRs of GLP1-RA or SGLT2i initiation increased over time but remained low (<0.6 initiations per 100 person-months) in all years studied. Medication initiation was less common among those of Black or Other race/ethnicity (HR 0.81 [95% confidence interval (CI) 0.79-0.84] and HR 0.84 [95%CI 0.75-0.95], respectively) and decreased with increasing SDI (HR 0.96 [95%CI 0.96-0.97]). Initiation was higher in ASCVD than CHF (0.35 vs. 0.135 initiations per 100 person-months). Moderate (e.g., nephropathy, non-alcoholic fatty liver disease) but not severe (e.g., advanced chronic kidney disease, cirrhosis) comorbidities were associated with higher probability of medication initiation.

Conclusions: Among older adults with T2D and either ASCVD or CHF, initiation of GLP1-RA or SGLT2i was low, suggesting a substantial deficit in delivery of guideline-recommended care or treatment barriers. Individuals of Black and Other race/ethnicity and those with higher area-level socioeconomic deprivation were less likely to initiate these medications.
Pengembangan Bahan Ajar Handout Untuk Pembelajaran Biologi Siswa Kelas X di SMA Negeri 1 Tegaldlimo Banyuwangi
Authors: Anggara Bima Apry , Warpala I Wayan Sukra , Julyasih Ketut Srie Marhaeni
Published: November 2022

This study aims to determine product design, validity and practicality of handout teaching materials. This study uses the ADDIE model (analyze, design, development, implementation, and evaluation). The trials carried out were validity tests and practicality tests by distributing questionnaires to material experts, media experts and students. The location of the trial was at SMA Negeri 1 Tegaldlimo. The results of the research are, product design produces handout teaching materials, the validity of handout teaching materials is 79.9% with appropriate criteria, and the practicality of handout teaching materials is 88.8% with very feasible criteria. Based on these results, the handout teaching materials are feasible and very practical to use in class X biology learning at SMA Negeri 1 Tegaldlimo.
Analysis of Diversity and Abundance Soil Insects in Taman Gumi Banten, Forest of Wanagiri Village, Buleleng
Authors: Riawan I Made Oka , Bestari Ida Ayu Purnama , Saraswati Ni Luh Putu Ananda Saraswati , Adnyaningsih Ni Kadek Putri , Perdiana I Kadek
Published: November 2022

The forest in Wanagiri Village about 1.055 ha, and almost 250 ha of that forest managed as “village forest”. Village forest is the forest that is used by villagers, and in addition to being a natural reservoir area and maintaining water availability. This research aims to explored diversity and abundance soil insects that play a role in maintaining soil fertility. Surface insects were collected using the pitfall trap method, while infauna or ground insects were collected using the core method. The site of this research consists of 8 plots each site with random purposive sampling. The results showed that macrofauna species were higher than infauna. The diversity Index of soil insects is in the low category (0.355987).
Pengembangan Media Pembelajaran Flipbook Untuk Materi Sistem Koordinasi Berorientasi budaya lokal Pada Pelajaran Biologi SMA
Authors: Febrianti Ni Wayan , Ida Bagus Putu Arnyana , Ida Ayu Purnama Bestari
Published: November 2022

The purpose of this research is to develop flipbook learning media based on local culture with valid and practical coordination system materials. The research was conducted on students of class XI SMAN 1 Susut. Development using the ADDIE model. The product created in this research displays components such as videos, brief explanations, pictures, practice questions and quizzes. Local culture-based flipbook contains examples of local culture in each sub-material. The validity test in this study was carried out by material experts, media experts and linguists. The practicality test was carried out by 5 biology teachers and 12 class XI students of SMAN 1 Susut. Data analysis was carried out using qualitative and quantitative descriptive methods to determine the feasibility and practicality of the developed flipbook. The results showed that: (1) The results of each stage of development created a product in the form of a local culture-based flipbook on the material of the XI class coordination system, (2) The validity of the local culture-based flipbook on the coordination system material from the material expert got a score of 1 with very valid criteria, from media experts got a score of 1 with very valid criteria and from linguists got a score of 1 with very valid criteria, (3) the practicality of flipbook learning media based on local culture material for the coordination system from the teacher got a percentage of 90.88% categorized as very practical and from students got a percentage of 96 .3% are categorized as very practical, so the average practicality of flipbook learning media is 93.59% in the very practical category. Based on the results of the study of flipbook learning media based on local culture, the coordination system material developed was very valid and very practical to be used as teaching material for the XI class coordination system material at SMAN 1 Susut.
Avaliação in vitro da eficácia de diferentes solventes sobre os cones de guta-percha F3
Authors: de França Maria Isabel Anastácio Faria , Pinto Débora Cristina de Souza , Soldá Mayara Machado , Cruz Alessandra Timpone Goes , de Aragão Egas Moniz , Heck Alexandre Roberto
Published: November 2022

O objetivo do presente estudo é avaliar, in vitro, a capacidade solubilizadora de diferentes solventes sobre cones de guta-percha F3. Para tanto, 100 cones de guta-pecha F3 foram divididos em 5 grupos de acordo com o solvente utilizado: xilol, eucaliptol, citrol, óleo de laranja e água destilada. Os cones foram pesados inicialmente e colocados imersos nos solventes por 15 minutos, após este período os cones foram mantidos em estufa por 48 horas a 37º. Os cones foram novamente pesados e estabeleceu-se a perda média para cada grupo de solvente. Os autores observaram que o grupo do xilol apresentou maior média de perda de peso, com diferença estatisticamente significante para os outros grupos testados (p<0,0001). Já a água destilada (grupo controle) apresentou a menor média de perda de peso, com diferença estatisticamente significante para os demais grupos avaliados. Não houve diferença estatisticamente significante entre os demais grupos. Concluiu-se que o xilol foi o solvente que apresentou melhor solvência sobre a guta-percha. Contudo, atenção deve ser dada ao potencial tóxico deste material.
Correção da extensão basal de sobredentadura inferior: técnica direta-indireta de reparo
Authors: Wanghon Zuila Maria Lobato , Reginaldo Isabela , Pasetto Julia Jacoby , Zimmermann Glaucia Santos , Philippi Analucia Gebler , Gonçalves Thais Marques Simek Vega
Published: November 2022

O sucesso da prótese total está diretamente relacionado à sua retenção e estabilidade. Nesse sentido, a cobertura correta da área basal é essencial para que a prótese seja funcional e melhore o conforto e a eficiência durante a função. Próteses mal adaptadas ou instáveis podem ainda sobrecarregar os tecidos de suporte, além de serem iatrogênicas para implantes e sistemas retentivos de sobredentaduras, o que pode levar à perda precoce dos mesmos. Nesses casos, pode-se fazer o reembasamento temporário da base de resina acrílica. Esse procedimento é realizado pelo próprio cirurgião-dentista e visa promover maior contato entre a base da prótese e o rebordo edêntulo, aumentando a retenção e estabilidade da prótese de forma temporária, até que uma nova prótese seja confeccionada. A técnica direta-indireta, detalhada nesse artigo, é bastante vantajosa, pois ao ser realizada sobre um modelo de gesso, não causa desconfortos ao paciente. Em acréscimo, pode ser realizada em sessão única, no próprio consultório, com materiais comuns à prática clínica, não havendo necessidade de envio do trabalho ao laboratório, o que reduz o custo, além de apresentar resultados imediatos ao paciente.
REVITALISASI KEBIJAKAN PEMBELAJARAN AL ISLAM DAN MUHAMMADIYAHAN DI UNIVERSITAS MUHAMMADIYAH METRO
Authors: Sujino Sujino , Marlisa Lusi
Published: November 2022

Pendidikan Al-Islam dan Kemuhammadiyahan di Perguruan Tinggi Muhammadiyah dapat berfungsi sebagai kekuatan gerakan bagi Muhammadiyah (Quwwatul  Harokah al-Muhammadiuah) karena dapat menjadi basis kekuatan spiritual, moral, dan intelektual. Pendidikan Al-Islam dan Kemuhammadiyahan (AIK) juga sebagai identitas karakter warga kampus. Perkembangan peradaban yang cepat dan pesat dengan teknologi informasi di era digitalisasi serta inovasi teknologi (gawai, internet, media sosial) yang semakin berkembang, sangat mempengaruhi daya serap informasi, pemahaman dan praktik keislaman mahasiswa. Kesenjangan dalam ilmu pembelajaran AIK masih mnyisakan masalah, antara lain: kurikulum masih belum menggambarkan standar lulusan dan masih menitik beratkan pengetahuan. Dosen pengampu belum disiapkan secara profesional, dosen pengampu belum memilki komitment tinggi pada Muhammadiyah dan dosen AIK belum dimiliki semua jurusan, termasuk Kebijakan Universitas Muhammadiyah Metro belum menempatkan prioritas penting bagi pendidikan AIK. Tujuan dari penelitian ini untuk mengatahui Gambaran dan standar Pembelajaran AIK di Universitas Muhammadiyah Metro, serta untuk Mengetahui Revitaliasi Kebijakan LPM dan Wakil Rektor 4 terhadap Pembelajaran AIK di Univeritas Muhammadiyah Metro. Metode yang digunakan dalam penelitian ini menggunakan jenis penelitian kualitatif deskriptif, dengan menggunakan pendekatan studi kasus (case study). Penelitian ini memusatkan diri secara intensif pada satu obyek tertentu yang mempelajarinya sebagai suatu kasus.Revitalisasi kebijakan pembelajaran AIK didasari oleh realitas di Universitas Muhammadiyah Metro adalah keniscayaan. Reliata yang  kian melemah itu perlu segera di respon positif. Revitalissi berarti menggaerahkan  AIK dalam dimensi  transfer knowlagde dan transfer value, memvitalkan kembali  fungsi AIK yang sudah berjalan. Dengan mempertimbangkan beberapa aspek. Tujuan pendidikan Muhammadiyah yang dalam grand Desain rencana yang akan mendorong terwujudnya Indonesia yang berkemajuan yang dimulai dengan revitalisasi AIK di perguraun Muhammadiyah khususnya Universitas Muhammadiyah Metro.
Conformación de redes y circuitos educativos internacionales. El caso de la Primera Reunión Sudamericana de Asociaciones de Profesores de Educación Física, 1950
Authors: Scharagrodsky Pablo Ariel
Published: November 2022

El siguiente trabajo analiza, a partir de la historia social y cultural de la educación, los tópicos y propuestas abordadas en la Primera Reunión Sudamericana de Asociaciones de Profesores de Educación Física. Asimismo, examina al evento internacional como un lugar en el que sobresalieron las voces de ciertos especialistas, así como la presencia de determinadas instituciones. Conceptualiza al evento sudamericano como parte y, al mismo tiempo, producto de un circuito más complejo y diversificado de reuniones, jornadas, congresos, viajes de estudio y alianzas personales e institucionales producidos muy especialmente en la década de 1940 en América Latina. Se identifica a la reunión sudamericana como un espacio de discusión conceptual articulado con reclamos corporativos, fusionado con narrativas nacionales y sudamericanas.
Reseña de Rodolfo Rozengardt y Fabio Krivzov (compiladores) - La Pampa en Movimiento. 30 años. 1ª edición – Buenos Aires: Editores asociados, 2021. 422 páginas. ISBN 978-987-4150-52-3
Authors: Rodríguez Piñero Cristian David
Published: November 2022

Reseña de  La Pampa en Movimiento. 30 años de R. Rozengardt  y F. Krivzov (comp.) por Cristian David Rodríguez Piñero.
Open data application to evaluate exposure of wildfire to water resources: A case study in Johor, Malaysia
Authors: Sanin Fara Aiza Md , Alias Nor Eliza , Kanniah Kasturi Devi , Kadir Mariyana Aida Ab. , Mohamad Izni Izzati , Paramasivam Rasnavi
Published: November 2022

Climate change impacts wildfire events as well as water availability. Exposure of water resources to wildfire can reduce water quality supplied to humans and resulting health problems. On the other hand, water resources such as rivers and ponds are essential in wildfire firefighting. This paper intended to assess spatially the exposure of water resources to wildfire. A case study in Johor, Malaysia is utilised to asses and determine locations of water bodies in an area which are vulnerable to wildfire. Post wildfire runoff water can contaminate water resources. Fire data collected by MODIS from 2000–2020 are used to create a hotspot map. Water resources and waterbody data originated from Department of Surveying and Mapping Malaysia used to identify the stream and dams that are exposed to wildfire. 5 class exposure level has been set to show the degree of closeness of water resources to wildfire hotspot area. Using the spatial analysis method, low to high level of potential wildfire-water exposures were able to be locate. Analysis shows, 7% of Johor’s water sources is exposed to medium levels of wildfire, while just 1% is exposed to the highest levels. The majority of the streams have very low levels of exposure. In addition, the wildfire-water exposure map aids in first respondent preparedness and planning.
Topical Diagnosis and Determination of the Primary Hyperaldosteronism Variant
Authors: Shidlovskyi Viktor O. ,   Surgery Department, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine, Shidlovskyi Olexandr V. ,   Surgery Department, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine, Tovkai Oleksandr A. ,   Ukrainian Scientific and Practical Center of Endocrine Surgery, Endocrine and Tissue Transplantation of the Ministry of Health of Ukraine, Kyiv, Ukraine, Sheremet Michael I. ,   First Surgery Department, Bukovinian State Medical University, Chernivtsi, Ukraine,   Michael I. Sheremet, First Surgery Department of Bukovinian State Medical University, Holovna str., 191, 58018, Chernovtsy, Ukraine, E-mail: mihayl71@gmail.com; Phone: +380956064607, Maksymyuk Vitaliy V. ,   First Surgery Department, Bukovinian State Medical University, Chernivtsi, Ukraine, Tarabanchuk Volodimir V. ,   First Surgery Department, Bukovinian State Medical University, Chernivtsi, Ukraine, Ivanovych Shved M. ,   Department of First Emergency Medical Aid and Emergency Medical Treatment, Ternopil, Ukraine, Heryak Mykolaivna S. ,   Second Department of Obstetrics and Gynecology, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine, Andreychyn Mykhailovych S. ,   Department of Propaedeutic of Internal Medicine and Phthisiology, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine, Hanberher Igorivna I. ,   Department of Propaedeutic of Internal Medicine and Phthisiology, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine, Piddubna Antonina A. ,   Department of Clinical Immunology, Allergology and Endocrinology, Bukovinian State Medical University, Chernivtsi, Ukraine
Published: November 2022

Laboratory diagnosis of primary hyperaldosteronism is based on determining blood levels of aldosterone, renin on request, potassium, and sodium. The results of these studies are significantly influenced by drugs, preparation for the study and blood collection methods, age, gender, and concomitant diseases. The work analyzes the factors influencing the results of the study of aldosterone and identifies the main ways of their exclusion at each stage of the diagnosis. Their neglecting is the determining factor in obtaining false results, diagnostic errors, the selection of ill-treatment tactics, and inadequate treatment. All these diagnostic problems are covered in a variety of ways in the review, which is based on the analysis of results of individual authors’ research and practical and clinical recommendations from leading world endocrinological associations.

Results of laboratory diagnostics of PHA depend on the influence of many factors. Among them, it is essential to use different medication drugs, the rules for preparing for the study, and the method of conducting it. In assessing the results of research, it is necessary to take into account not only the indicators of the level of aldosterone in the blood but also the features of the clinical course of the disease, its compliance to the drug therapy, age, and gender of the patients.
The Severity of Oxidative Stress in Comorbid Chronic Obstructive Pulmonary Disease (COPD) and Hypertension: Does it Depend On ACE and AGT Gene Polymorphisms?
Authors: Marushchak Mariya ,   Department of Functional and Laboratory Diagnostics, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine,   Mariya Marushchak, Professor and Head of the Functional and Laboratory Diagnostics Department, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine, E-mail: marushchak@tdmu.edu.ua, Maksiv Khrystyna ,   Department of Medical Rehabilitation, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine, Krynytska Inna ,   Department of Functional and Laboratory Diagnostics, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine, Dutchak Olha ,   Department of Pediatrics, Institute of Postgraduate Education, I. Horbachevsky Ternopil National Medical University,Ternopil, Ukraine, Behosh Nina ,   Department of Functional and Laboratory Diagnostics, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine
Published: November 2022

There is an increasing number of studies suggesting the role of genetic factors in the development and progression of chronic obstructive pulmonary disease and hypertension. Therefore, our study aimed to establish the role of ACE and AGT gene polymorphisms in the mechanisms behind the development of oxidative stress in patients with concomitant chronic obstructive pulmonary disease and hypertension. The study group consisted of 96 patients: Group 1 (individuals with a chronic obstructive pulmonary disease), Group 2 (individuals with arterial hypertension), Group 3 (individuals with a chronic obstructive pulmonary disease and arterial hypertension). The control group consisted of 20 healthy subjects. ACE and AGT gene polymorphisms were determined by polymerase chain reaction amplification. Detection of intracellular reactive oxygen species levels was performed by EPICS XL cytometer (Beckman Coulter, USA) with dichlorodihydrofluorescein diacetate and dihydroethidium. Serum levels of 8-isoprostane were assayed with ELISA, Cayman Chemicals (USA). No significant correlations between ACE and AGT gene polymorphisms and parameters of oxidative stress in a setting of comorbid chronic obstructive pulmonary disease and hypertension were observed. However, the increase in oxidative stress parameters was observed to be the most significant in patients with chronic obstructive pulmonary disease + hypertension and with I/I genotype of the ACE gene, which was due to their lowest values in virtually healthy individuals. This suggests that I/I genotype may be associated with lower levels of reactive oxygen species production compared with other genotypes.