bluuebunny/crossref_metadata_2025 huggingface dataset:
The Swedish Jordan Expedition 2014 at Tall Abu al-Kharaz. Preliminary results from areas 12 and 13
Authors: Fischer Peter M. , Bürge Teresa
Published: June 2018

In previous seasons excavations have concentrated on the periphery of the city of Tall Abu al-Kharaz, a multi-period tell in the Central Jordan Valley. Tall Abu al-Kharaz flourished from the Early Bronze to Islamic times, from roughly 3200 BC to the 10th century AD. The main object of the field work in 2014 was to investigate the area around the geographical centre of the city (Area 12). Preference was given to further investigation of the Iron Age sequence, i.e. the period from the 12th to the 7th centuries BC (local Phases IX–XV). Another task was to extend the excavations in the northern part of the city, Area 7, which produced essential information on the Iron Age, towards the south (Area 13) in order to generate a coherent picture of Iron Age occupation in the city’s northern half. Domestic structures and a system of fortified walls were uncovered. The rich find assemblage confirmed connections with the Cypriote and Phoenician sphere of culture. The exposure of the remains in general stopped when Late Bronze Age levels were reached. Nevertheless, remnant “islands” of Late and Early Bronze Age remains, left aside by the Iron Age settlers, were uncovered. A burial pit with the skeleton of a female from Byzantine or Abbasid times was found in Area 12, cut into Iron Age layers.
Removal of nickel and methylene blue from aqueous solutions by steel slag as a low cost adsorbent
Authors:   Center for Advanced Chemistry, Institute of Research & Development, Duy Tan University, Le Van Thuan , Le Hoang Sinh ,   Center for Advanced Chemistry, Institute of Research & Development, Duy Tan University, Tran Xuan Vu ,   Faculty of Environmental and Chemical Engineering, Duy Tan University, Tran Thi Kieu Ngan ,   Faculty of Environmental and Chemical Engineering, Duy Tan University, Vo Dang Quang ,   Faculty of Environmental and Chemical Engineering, Duy Tan University, Tran Bao Chau ,   Faculty of Environmental and Chemical Engineering, Duy Tan University, Ngo Quoc Phu ,   Faculty of Environmental and Chemical Engineering, Duy Tan University, Le Thi Xuan Thuy ,   Faculty of Environment, Da Nang University of Science and Technology
Published: June 2018

Nowadays, wastewater from various industries contains a large number of harmful heavy metals and coloring agents, which have to be removed to restore the quality of the environment. In this study, the removal of nickel ions (Ni2+) and methylene blue (MB) from the aqueous solution using steel slag as a low cost adsorbent was investigated. The chemical and mineralogical compositions, as well as the surface area of slag, were analyzed by using X-ray fluorescence spectroscopy, X-ray diffraction, and the Brunauer-Emmett-Teller method (BET). The effect of several important parameters such as contact time, adsorbent dose, pH, temperature, and initial adsorbate concentration on the adsorption process was studied systematically by batch experiments. The adsorption data were well correlated with the Langmuir isotherm model by all samples. The maximum adsorption capacity of the raw slag samples was 36.49 mg/g for Ni2+ and increased from 0.68 to 1.98 mg/g for MB after being acid-activated. The determined thermodynamic parameters indicate that the adsorption of Ni2+ and MB on steel slag is spontaneous in nature, endothermic (for Ni2+), and exothermic (for MB).
Using NMR, X-ray, and CD analysis in the study on natural products obtained from Vietnamese plant and fungi in terms of pharmaceutical product development
Authors:   Faculty of Chemistry, Vinh University, Vietnam, Tran Dinh Thang , Vo Cong Dung ,   Faculty of Chemistry, Vinh University, Vietnam, Nguyen Ngoc Tuan ,   Faculty of Chemistry, Vinh University, Vietnam, Doan Manh Dung ,   Faculty of Chemistry, Hue University of sciences - Hue University, Vietnam, Wu Yang-Chang ,   School of Pharmacy, College of Pharmacy, China Medical University, Taiwan, Wu Tian-Shung ,   School of Pharmacy, National Cheng Kung University, Taiwan
Published: June 2018

NMR, X-ray analysis, and CD methods are powerful techniques for the study of absolute configuration of bioactive compounds from natural resources. This study presents the results of a joint-study between Vietnam and Taiwan on the bioactive compounds obtained from Vietnamese plants and fungi. Among the tested compounds, hexatenuin A displayed the most significant inhibition of superoxide anion generation and elastase release. These triterpenoids may be used as potential anti-inflammatory agents.
Single port laparoscopic colectomy for colonic cancer
Authors:   Hue Central Hospital, Vietnam, Pham Trung Vy , Pham Nhu Hiep ,   Hue Central Hospital, Vietnam, Ho Huu Thien ,   Hue Central Hospital, Vietnam, Pham Anh Vu ,   Hue Central Hospital, Vietnam, Phan Hai Thanh ,   Hue Central Hospital, Vietnam, Nguyen Thanh Xuan ,   Hue Central Hospital, Vietnam, Tran Nghiem Trung ,   Hue Central Hospital, Vietnam, Pham Xuan Dong ,   Hue Central Hospital, Vietnam, Van Tien Nhan ,   Hue Central Hospital, Vietnam, Mai Trung Hieu ,   Hue Central Hospital, Vietnam
Published: June 2018

Objectives: The evaluation of feasibility, safety, and outcomes of single port laparoscopic colectomy (SPLC) for colonic cancer. Prospective study of 114 patients with colonic cancer (84 right side, 17 left side, and 13 sigmoid colon) who underwent SPLC between October 2010 and October 2016 in Hue Central Hospital. Results: Mean age of patients was 56.1±15.2 (25-87 years), male/female ratio was 70/44. Mean BMI was 23.5±2.2 kg/m2. Procedures included 84 right hemi-colectomies (73.7%), 17 left hemi-colectomies (14.9%), and 13 sigmoidectomies (11.4%). Six cases required additional ports, and 19 were converted to open surgery. Mean tumor size was 3.7±2.7 cm. Stage I: 6.1%; stage IIa: 43.9%; stage IIIa: 36.8%; and stage IIIc: 13.2%. Mean operation time was 160.5±75.5 min. There had been no deaths/intraoperative complications. Mean incisional length (including extraction) was 5.5±2.2 cm. Mean lymph nodes was 16.2±4.5. Mean hospital stay was 7.5±6.1 days. The surgical site infection rate was 3.5%, and 1 patient required reoperation (anastomotic leakage: 0.9%). After 32.2±7.5 (3-65 months) follow-up, there were no late surgical complication, incisional hernia, or incision metastasis. There were five local recurrences, and three patients developed liver metastasis in the open conversion group. The overall survival time after 2 years was 87.5%, and after 5 years, it was 59.4% (Kaplan-Meier). Conclusion: SPLC is feasible and safe procedure for the treatment of colon cancer. The cosmetic value is better (short incision confounded by umbilicus). Other outcomes were equivalent to conventional laparoscopy.
A simple, efficient and universal method for the extraction of genomic DNA from bacteria, yeasts, molds and microalgae suitable for PCR-based applications
Authors:   National Key Laboratory of Enzyme and Protein Technology, University of Science, Vietnam National University, Hanoi, Do Thi Binh Xuan Loc , Tran Van Tuan ,   Faculty of Biology, University of Science, Vietnam National University, Hanoi,   National Key Laboratory of Enzyme and Protein Technology, University of Science, Vietnam National University, Hanoi, Nguyen Thi Khuyen ,   National Key Laboratory of Enzyme and Protein Technology, University of Science, Vietnam National University, Hanoi, Vu Xuan Tao ,   National Key Laboratory of Enzyme and Protein Technology, University of Science, Vietnam National University, Hanoi, Dao Bich Ngoc ,   National Key Laboratory of Enzyme and Protein Technology, University of Science, Vietnam National University, Hanoi, Nguyen Hoai Ha ,   Institute of Microbiology and Biotechnology, Vietnam National University, Hanoi
Published: June 2018

The extraction of genomic DNA from microbial cells plays a significant role in PCR-based applications such as molecular diagnosis, microbial taxonomy, screening of genetically engineered microorganisms, and other such PCR-based applications. Currently, many methods for extraction of genomic DNA from microorganisms have been developed. However, these methods either require hazardous chemicals or consist of time-consuming steps for effective execution. In this study, we have established a simple and universal genomic DNA extraction method for different microorganisms including bacteria, yeasts, molds, and microalgae. Our method does not require harmful reagents such as phenol and chloroform for the extraction process to minimize the generation of hazardous wastes. The obtained genomic DNA products displayed high concentrations and represented a good purity level with the average 260 nm/280 nm absorbance ratios (A260/280) that range from 1.6 to 2.0. The DNA molecules further remained considerably intact when analyzed on agarose gels. More importantly, these DNA products were qualified through successful PCR amplifications of 16S rRNA gene, rDNA internal transcribed spacer (ITS), or 18S rRNA gene from genomes of bacteria, fungi, and microalgae respectively. Furthermore, with the extracted genomic DNA products, the processes of the identification of the haploid and diploid states of the Saccharomyces yeast strains or detection of putative strains of Aspergillus oryzae and Aspergillus flavus that have been isolated from infected food materials through PCR analyses are facilitated. The genomic DNA extraction method established in this study is easy to manage, time saving and cost-effective, and environmentally friendly.
Síndrome de ovario poliquístico
Authors: Fonseca Villanea Carlos
Published: June 2018

Se fijó una revisión sobre la presentación clínica para el diagnóstico del síndrome de ovario poliquístico. Inicialmente se exhibe conceptos sobre la etiología y fisiopatología. Posteriormente, se habla sobre la historia para llegar a los criterios diagnósticos. Finalmente, se explica el manejo; exponiendo las diferencias en los casos cuando las pacientes tienen o no deseo de concebir.
OPTIMIZATION OF BOX TYPE GIRDER WITH AND WITHOUT INDUSTRIAL CONSTRAINTS
Authors: Abid Muhammad , Khan Shahbaz Mahmood , Wajid Hafiz Abdul
Published: June 2018

In this paper three dimensional nonlinear finite element analysis is performed for the optimization of an overhead crane box girder for capacity (50~120ton) and span (10 ~ 32 m) for safe bending stress and deflection with minimum mass and volume. A customized optimization code is developed using interpolative relations and correction factors to achieve optimized results with and without considering industrial constraints. A cutting and welding plan is developed to provide a standard operating procedure for the manufacturing of the box girder. Bill of materials, box girder design dimensions, and cutting and welding lengths are recorded with considerable time saving. ABSTRAK: Kertas ini mengkaji tentang analisis tidak linear tiga dimensi unsur terhingga bagi mengoptimumkan kotak kren galang atas kepala bagi kapasiti (50 ~ 120 tan) dan pada kadar (10 ~ 32 m) bagi takat lentur selamat dan pesongan dengan jisim minimum dan isipadu. Kod optimum penyesuaian telah direka mengguna pakai kaitan interpolatif dan faktor-faktor pembetulan bagi mencapai keputusan yang optimum, dengan dan tanpa mengambil kira kekangan industri. Pelan pemotongan dan kimpalan telah dicipta bagi menyediakan prosedur operasi biasa bagi pembuatan kotak galang. Rang undang-undang bahan, dimensi reka bentuk kotak galang, pemotongan dan panjang kimpalan telah direkodkan dengan penjimatan masa yang besar.
HYDROGEN PRODUCTION FROM ETHANOL DRY REFORMING OVER LANTHANIA-PROMOTED Co/Al2O3 CATALYST
Authors: FAYAZ FAHIM , NGA NGUYEN THI ANH , PHAM THONG LE MINH , DANH HUONG THI , ABDULLAH BAWADI , SETIABUDI HERMA DINA , VO DAI-VIET NGUYEN
Published: June 2018

La-promoted and unpromoted 10%Co/Al2O3 catalysts were synthesized using wet a impregnation method and evaluated in a quartz fixed-bed reactor at different CO2:C2H5OH ratios of 2.5:1-1:2.5 and a reaction temperature of 973 K under atmospheric pressure. X-ray diffraction measurements detected the presence of Co3O4 and CoAl2O4 phases on the surface of both promoted and unpromoted catalysts. BET surface area of promoted and unpromoted 10%Co/Al2O3 catalysts was about 143.09 and 136.04 m2.g-1, respectively. The La promoter facilitated Co3O4 reduction, improved the degree of reduction from 86 to 98% and increased metal dispersion from 9.11% to 16.64%. The La-promoted catalyst appeared to be a better catalyst in terms of catalytic activity and product yield regardless of reactant partial pressure. Both C2H5OH and CO2 conversions improved significantly with an increase in CO2 partial pressure from 20 to 50 kPa for both catalysts whilst a decline in catalytic performance was observed with rising C2H5OH partial pressure. La addition improved C2H5OH and CO2 conversions up to about 74.22% and 33.80%, respectively. ABSTRAK: Penggalak-La dan bukan penggalak-La mangkin 10%Co/Al2O3 dihasilkan menggunakan kaedah impregnasi basah dan dinilai dalam reaktor alas-tetap quarza pada pelbagai nisbah CO2:C2H5OH sebanyak 2.5:1-1:2.5 dan suhu tindak balas sebanyak 973 K di bawah tekanan atmosfera. Hasil daripada ukuran pembelauan X-ray, didapati terdapat kehadiran fasa Co3O4 dan CoAl2O4 pada permukaan kedua-dua mangkin penggalak dan bukan penggalak. Permukaan kawasan BET pada penggalak dan bukan penggalak mangkin 10%Co/Al2O3 adalah masing-masing sebanyak 143.09 dan 136.04 m2.g-1. Penggalak-La membantu dalam pengurangan Co3O4,membaiki peratus penurunan daripada 86 kepada 98% dan menambah penyebaran logam daripada 9.11% kepada 16.64%. Mangkin penggalak-La dilihat sebagai mangkin terbaik dari segi aktiviti pemangkinan dan hasil pengeluaran, biarpun pada tekanan separa reaktan. Kedua-dua penukaran C2H5OH dan CO2 meningkat dengan ketara dengan kenaikan separa tekanan CO2 daripada 20 kepada 50 kPa bagi kedua-dua pemangkin, sementara penurunan dalam aktiviti pemangkinan dilihat dengan kenaikan tekanan separa C2H5OH. Penambahan La meningkatkan penukaran C2H5OH dan CO2, masing-masing sebanyak 74.22% dan 33.80%.
GREEN SYNTHESIS OF SILVER NANOPARTICLES USING SAGO (METROXYLON SAGU) VIA AUTOCLAVING METHOD
Authors: Jamaludin Aliyah , Mohammad Faizal Che Ku
Published: June 2018

Sago (metroxylon sagu) is a polysaccharide bio resource, which is biodegradable and low in toxicity that can be found in large scale in Mukah, Sarawak.Â  A simple green method of synthesizing silver nanoparticles (AgNPs) has been developed using sago dissolved in water as the reducing agent. The mixture of dissolved sago and silver nitrate (AgNO3) were autoclaved at 121 Â°C for 20 minutes. The size, morphology and structures of the AgNPs formed in the sago solution were investigated through UV-Vis spectrophotemeter, XRD and FESEM analysis. The synthesized AgNPs were spherical in shape and well distributed with average particle sizes of 19.3 Â± 2.7 nm.ABSTRAK: Sago (Pokok Rumbia) adalah sumber bio polisakarida yang bioterurai dan rendah ketoksikan yang boleh didapati dalam skala yang besar di Mukah, Sarawak. Satu kaedah hijau yang mudah untuk mensintesis nanopartikel perak telah dihasilkan dengan menggunakan sagu yang larut dalam air sebagai ejen penurunan. Campuran sagu yang dilarutkan dan perak nitrat (AgNO3) telah autoklaf pada suhu 121Â°C selama 20 minit. Saiz, morfologi dan struktur nanopartikel perak yang terhasil di dalam larutan sago telah disiasat melalui analisis spektrofotometer UV-Vis, XRD dan FESEM. Nanopartikel perak yang dihasilkan adalah berbentuk bulat dengan purata saiz partikel 19.3 Â± 2.7 nm.
A MODIFIED MODEL BASED ON FLOWER POLLINATION ALGORITHM AND K-NEAREST NEIGHBOR FOR DIAGNOSING DISEASES
Authors: Zekriyapanah Gashti Mehdi
Published: June 2018

Exponential growth of medical data and recorded resources from patients with different diseases can be exploited to establish an optimal association between disease symptoms and diagnosis. The main issue in diagnosis is the variability of the features that can be attributed for particular diseases, since some of these features are not essential for the diagnosis and may even lead to a delay in diagnosis. For instance, diabetes, hepatitis, breast cancer, and heart disease, that express multitudes of clinical manifestations as symptoms, are among the diseases with higher morbidity rate. Timely diagnosis of such diseases can play a critical role in decreasing their effect on patientsâ€™ quality of life and on the costs of their treatment. Thanks to the large data set available, computer aided diagnosis can be an advanced option for early diagnosis of the diseases. In this paper, using a Flower Pollination Algorithm (FPA) and K-Nearest Neighbor (KNN), a new method is suggested for diagnosis. The modified model can diagnose diseases more accurately by reducing the number of features. The main purpose of the modified model is that the Feature Selection (FS) should be done by FPA and data classification should be performed using KNN. The results showed higher efficiency of the modified model on diagnosis of diabetes, hepatitis, breast cancer, and heart diseases compared to the KNN models. ABSTRAK: Pertumbuhan eksponen dalam data perubatan dan sumber direkodkan daripada pesakit dengan penyakit berbeza boleh disalah guna bagi membentuk kebersamaan optimum antara simptom penyakit dan mengenal pasti gejala penyakit (diagnosis). Isu utama dalam diagnosis adalah kepelbagaian ciri yang dimiliki pada penyakit tertentu, sementara ciri-ciri ini tidak penting untuk didiagnosis dan boleh mengarah kepada penangguhan dalam diagnosis. Sebagai contoh, penyakit kencing manis, radang hati, barah payudara dan penyakit jantung, menunjukkan banyak klinikal simptom jelas dan merupakan penyakit tertinggi berlaku dalam masyarakat. Diagnosis tepat pada penyakit tersebut boleh memainkan peranan penting dalam mengurangkan kesan kualitiÂ  hidup dan kos rawatan pesakit. Terima kasih kepada set data yang banyak, diagnosis dengan bantuan komputer boleh menjadi pilihan maju menuju ke arah diagnosis awal kepada penyakit. Kertas ini menggunakan Algoritma Flower Pollination (FPA) dan K-Nearest Neighbor (KNN), iaitu kaedah baru dicadangkan bagi diagnosis. Model yang diubah suai boleh mendiagnosis penyakit lebih tepat dengan mengurangkan bilangan ciri-ciri. Tujuan utama model yang diubah suai ini adalah bagi Pemilihan Ciri (FS) perlu dilakukan menggunakan FPA and pengkhususan data perlu dijalankan menggunakan KNN. Keputusan menunjukkan model yang diubah suai lebih cekap dalam mendiagnosis penyakit kencing manis, radang hati, barah payudara dan penyakit jantung berbanding model KNN.
PERITONEAL DIALYSIS IN TREATMENT FOR PATIENTS WITH ACUTE KIDNEY INJURY
Authors: Kolesnyk M. , Stepanova N.
Published: June 2018

This article is a review of the literature. Peritoneal dialysis (PD) was the first method of dialysis renal replacement therapy (DRRT), used for the treatment of patients with acute kidney injury (AKI). PD is able to correct metabolic, electrolyte, acid-alkali disorders and hypervolemia in patients with AKI. Continuous equilibration PD and continuous flow PD can provide of dialysis dose compared with extracorporeal methods of DRRT. However, PD is considered less effective than hemodialysis. In this regard, PD has used in patients with AKI, especially those who are hemodynamically unstable or at risk of bleeding because of severe coagulation abnormalities, in infants and children with AKI, and in patients with circulatory failure.
NEPHROLOGICAL PATHOLOGY IN SCHOOL AGE CHILDREN AS A COMPONENT OF THE RISK OFDEVEL OPMENT OF THE ARTERIAL HYPERTENSION
Authors: Bezruk V. V. , Nechitaylo YU.
Published: June 2018

In Ukraine the increase of amount of children registers with a hypertension.
SECRETORY IMMUNOGLOBULIN A LEVEL IN SALIVA OF CHRONIC KIDNEY DISEASE PATIENTS ON DIALYSIS
Authors: Klimchuk A. V.
Published: June 2018

Dialysis patients have elevated levels of markers of inflammation. Endotoxin of gram negative bacteria is one of the most potent inducers of inflammation. Endotoxin translocation from the gut into the blood can triggerproinflammatory response. Secretory immunoglobulin A (sIgA) in the mucous membranes can neutralize bacterial toxins and prevent their translocation, if the immune response is adequate.
PRUNE BELLY SYNDROME: A CASE REPORT
Authors: Solodkiy M.I. , Dzhuma K.A. , Zhezhera R.V. , Vylkov O.J.
Published: June 2018

Prune belly syndrome (PBS) is a rare congenital anomaly almost exclusive to males defined by the triad of abdominal muscle deficiency, severe urinary tract abnormality and cryptorchidism. The syndrome has a broad spectrum of affected anatomy with different levels of severity. We report a newborn boy with PBS. Diagnosis was confirmed by karyotyping, ultrasound investigation and intraoperative findings.
THE PREDICTORS OF HOSPITALIZATION IN HEMODIALYSIS PATIENTS
Authors: Dudar I. , Gonchar Y. , Savchuk V.
Published: June 2018

Summary. The aim of the present research was to identify predictors of hospitalization hemodialysis (HD) patients.

Materials and methods. The study involved 186 HD patients (49,38±0,94 у.) between Jan 2013 and Jan 2014. We studied the evolution of laboratory and treatment parameters, including dry body-weight, ultrafiltration, mean blood pressure, plasma albumin, Hb, absolute lymphocyte count, absolute neutrophil count, neutrophil-to-lymphocyte ratio, “hemoglobin variability ” all patients. The HD patients were divided for 2 groups: I group of outpatients (n=103), II group of hospitalized patients (n=83). Data from 83 hospitalized patients were compared with non-hospitalized patients. Laboratory and treatment parameters were assessed at least 3 months prior to admission.

Results. We found that hospitalization was 45,29±4,20 days, frequency of hospitalization 1,46±0,07. The likelihood of frequency and duration a hospitalization increased with patient age (p<0,05). Hospitalizations were preceded by a decrease level albumin, a decline in Hb concentration, a decrease absolute lymphocyte count, increase in the neutrophil-to-lymphocyte ratio, a reduction ultrafiltration.

The hozpitalization of patients with “stable hemoglobin ” was significantly lower than in patients with “low of hemoglobin variability”(p<0,005).

Conclusions. Patients whose noted these parameters should be monitored, thus, it may be useful to identify risk factors for hospitalization.
EVALUATIONOFRENAL REPLACEMENT THERAPYQUALITY IN UKRAINE: TIME FOR ACTIONS
Authors: Kolesnyk Mykola , Kozlyuk Nadiya
Published: June 2018

Background. Little is known about the status of renal replacement therapy (RRT) in the post-Soviet period of Ukraine. We therefore investigated the epidemiology and treatment outcomes of RRT in Ukrainian patients and put the results into an international perspective.

Methods. Data from the Ukrainian National Renal Registry for patients on RRT between 1 January 2010 and 31 December 2012 were selected. We calculated the incidence and prevalence of RRT per million population (pmp) and the 3-, 12- and 24-month patient survival using the Kaplan— Meier method and Cox regression

Results. There were 5985prevalent patients on RRT on 31 December 2012 (131,2 pmp). Mean age was 46,5 ± 13,8 years, 56% were men and 74% received haemodialysis (HD), while peritoneal dialysis and kidney transplantation both represented 13%. The most common cause of end-stage renal disease was glomerulonephritis (51%), while only 12% had diabetes. In 2012, 1129 patients started dialysis (incidence 24,8 pmp), with 80% on HD. Mean age was 48 ± 14 years, 58% were men and 20% had diabetes. Three, 12- and 24-month patient survival on dialysis was 95,1%, 86,0% and 76,4%, respectively. The transplant rate in 2012 was 2,1 pmp.

Conclusions. The incidence and prevalence of RRT and the transplantation rate in Ukraine are among the lowest in Europe, suggesting that the need for RRT is not being met. Strategies to reduce the RRT deficit include the development and improvement of transplantation and home-based dialysis programs. Further evaluation of the quality of Ukrainian RRT care is needed.
ANTIMICROBIAL RESISTANCE OF GRAM POSITIVE BACTERIA ISOLATED LNPATLENTS WLTHCHRONLCKLDNEYDLSEASSTAGE5D: PREVALENCE AND OUTCOMES
Authors: Shifris І.М. , Dudar I.O. , Krot V.F. , Kruglikov V.T. , Aleksieva N.G. , Nechyporuk T.N. , Grigorieva Е. М.
Published: June 2018

Bacterial infections in chronic kidney disease stage VD (CKD VD st.)patients are associated with increased risk of hospitalization and death.

 

The aim was to study of opportunistic pathogenic bacteria spectrum, their antibacterial resistance and the correlation between carriage and hospitalization and mortality rate in adult patients with CKD V D st.

Materials and methods. This prospective cohort, open-label, randomized, two-phase study included 146 patients with CKD V D st., 118 of whom were treated by hemodialysis (HD) and 28 by peritoneal dialysis (PD). The microbiological screening was conducted in the first stage. The examined material was throat/nose swabs and wet smears from skin of dialysis access site. On the second stage all patients were randomized on two groups: the group 1 (n=61) included patients with identified MRSA / VRE colonization and group 2 (n=85) included patients with colonization of other strains of opportunistic pathogenic bacteria. The groups were representative according to gender, age, type of kidney affections and renal replacement therapy (RRT) modality. The microbiological examination consisted of inoculation of hard medium by examined material. The end points were total amount of hospitalization and death events evaluated for 24 months after randomization.

Results. The colonization of some biotype of opportunistic pathogenic bacteria was established in 100% ofpatients. In total were isolated 347 strains of gram-positive bacteria: 284 and 63 in HD and PD patients, respectively. Without statistical significance approximately 20% of microorganism strains were resistant to 10 and more antibiotics according to dialysis modality. The MRSA colonization was identified in 49 (33.6%) patients (37/31.4% and 12/42.9% of HD u PD patients, respectively; p=0,246). The VRE colonization was established in 12 patients (10/8.5% and 2/7.1% of HD and PD patients, respectively; p=0.81).

The 70 hospitalization episodes were recorded during monitoring period. The significant majority was established in group 1 of patients (39/64% vs. 31/36.5 %; %2 =10.733, p=0,001) irrespective ofRRTmodality. The specific share ofdead persons in group 1 was in three times more than such share in group 2 (9/14.8% vs. 4/4.7 %; %2=4.42, p= 0.0355). The relative risks of hospitalization and death in the presence of MRSA/VRE colonization increased in 1.75 (95% CI: 1.252.5) and 3.14(95% CI: 1.01-9.7) times.

Conclusion. In this study was demonstrated that MRSA/VRE colonization in adult patients with CKD V D st. is a risk marker and a predictor of negative clinical prognosis. The RRT modality hadn’t significant effect on rate of negative consequences, particularly on rate of hospitalization and death in population of CKD V D st. patients.
PHARMACOKINETICS AND PHARMACODYNAMICS OF DRUGS IN PATIENTS WITH RENAL DYSFUNCTION
Authors: Zakon K. , Dudarenko V. , Kolesnyk M.
Published: June 2018

This review is dedicated to drugs` pharmacokinetics and pharmakodynamcs in patients with renal dysfunction.
EVALUATION OF THE MICROBIAL PROFILE AND ANTIBIOTIC RESISTANCE OF BACTERIA CAUSING URINARY TRACT INFECTION IN THE CHILDREN OF KYIV REGION
Authors: Lavrenchuk О. , Bagdasarova І.
Published: June 2018

The rapid growth of the acquired resistance of bacteria to antibacterial agents requires a revision of the selection ofempirical antimicrobial therapy in children with urinary tract infection (UTI).

The aim of this work was to investigate the etiological structure of uropathogen flora and its sensitivity to nitrofurantoin and antibacterial drugs ofother classes in children with UTI in Kyiv and region.

Materials and methods. Were examined in 95 children aged 3 to 17years in the aediatric Nephrology Department of, Institute of Nephrology NAMS of Ukraine” on the basis of clinical hospital №7 Kyiv city in 2015-2016. The disease duration ofthepatients rangedfrom 3 months to 4years.

Results.The microbial spectrum of the urine depended on theform of pyelonephritis, but all patients were dominated by enterobacteria E. coli and Kl. pneumoniae. The greatest number of patients was resistant to ampicillin, co-trimoxazol and cefuroxime – 10.5% of patients with acute and 17.2% with chronic pyelonephritis. The highest sensitivity was preserved in all patients before medications meronem and gentamicin – 100% and 94.7%, respectively. Most children in Kyiv and Kyiv region showed a high sensitivity to nitrofurantoin:furamag – 78.9-75.8%,furagin - 63.8-65.5%. Comparative analysis of therapeutic efficiency of drugsfuramag and co-trimoxazol, demonstrated greater therapeutic efficacy of nitro- furans in the absence of recurrences, compared with co-trimoxazol (Oto 1.68withp=0.021).

Conclusions. Among the causative agents of UTI in children of the city of Kyiv and Kyiv region was dominated by gram-negativeflora - E. coli and Kl. pneumoniae. High sensitivity to nitrofurantoin drugs, especiallyfuramag, cephalosporins, and gentamicin and meronem was documented. High rates of resistance to penicillin and co-trimoxazol was revealed. The use of the drugfuramag contributed to a more rapid, complete andpersistent normalization ofclinical and laboratory parameters in children with UTI.
HOSPITAL MORBIDITYINPATIENTS WITH CHRONICKIDNEYDISEASE STAGE UD
Authors: Shifris І. , Krot V. , Gonchar Y. , Krasyuk E. , Dudar I.
Published: June 2018

According to opinion of European researchers the expenses, associated with in–patient treatment, constitutes the significant part of health service expenditure in population of patients on renal replacement therapy (RRT). Only in few studies the hospitalization levels were compared for population ofpatients on hemodialysis (HD) and peritoneal dialysis (PD).

Aim. The aim of this study was analysis the hospital morbidity pattern in patients with CKD stage 5D on HD and PD.

Materials and methods. It was performed the retrospective (for period 01 Jan to 31 Dec 2013) analysis of hospitalization structure and rate for patients, were treated by RRT. All hospitalization admissions were assessed in view of modality and duration of RRT, demographic/gender characteristics, and renal affection type. In 2013 the RRT treatment were provided to 351 patients, including the 296 on HD and 55 on PD.

Results. Overall 173 cases of hospitalization were recorded, including 142 (82,08%) primary and 31 (17,92%) readmissions. Irrespective of RRT modality the three most common causes of hospitalization were cardiovascular diseases (CVD), bacterial infections, and anemia. 41 hospitalization was caused by RRT initiation (28 HD and 13 PD), the most

of patients aged 45 years and older. The hospitalization rate in PD patients with was significantly higher than in patients on HD: 70,9±6,1% vs. 34,8±2,8%, respectively;p<0,0001. The duration of hospitalization was significantly higher by HD– than PD patients (30,09±17.21 vs. 21.82±10.56, respectively; p=0,0007).

 

Conclusions. During follow–up, at least one hospitalization had more than 40%patients with CKD stage 5D. In HD patients the most common causes of hospitalization were bacterial infections, CVD and anemia. Anemia, CVD and bacterial infections were the most frequent causes hospitalization in PD patients.
REVISÃO SOBRE O USO DE TÉCNICAS DE ENCONTRABILIDADE NA WEB
Authors: Marsico Gonçalves Rafael Gabriel , Petrucelli Erick Eduardo
Published: June 2018

Os recentes avanços tecnológicos possibilitaram o acesso à informação, recuperação de dados, assim como o uso e apropriação da informação e relação entre dados de diferentes dispositivos e sistemas. Diante deste cenário, surgiu o termo Findability, que mostra a facilidade em se encontrar qualquer informação a respeito de algo ou alguém a partir de qualquer local e a qualquer momento, usando ferramentas de busca. Este trabalho teve como objetivo desenvolver uma pesquisa literária de técnicas em Encontrabilidade e suas aplicações, assim como verificar sua utilização. O objetivo da pesquisa foi atingido, pois foi possível fazer um levantamento bibliográfico, entre publicações de diversos autores da área, e verificar que o objeto da pesquisa já vem fazendo parte da vida dos usuários, pois a Encontrabilidade no ambiente informacional, leva os usuários da Web a conseguirem encontrar as informações que buscam, a qualquer momento, de qualquer lugar, desde que estejam conectados a Internet.
DISPUTAS NO MERCADO DE EQUIPAMENTOS PARA LABORATÓRIOS DE PESQUISA
Authors: Gama Filho Angelino dos Santos , Neto Martin Mundo
Published: June 2018

Este artigo apresenta a disputa entre grandes empresas fornecedoras de fermentadores para a produção de etanol de segunda geração como processo de construção de novos mercados, por meio de análise das informações institucionais publicadas pelas empresas envolvidas, além de um conjunto de entrevistas com colaboradores da DuPont para obter os detalhes da estratégia de escolha do fornecedor durante a implantação do Centro de Inovação Brasil da DuPont em Paulínia / SP. O objetivo deste trabalho é indicar como as instituições que sustentam o mercado de fermentadores ocorreram em função da ação de atores sociais hábeis, uma vez que a empresa Sartorius, apesar de líder mundial neste segmento e possuir, até aquele momento, contrato de exclusividade com a DuPont, em âmbito global, perdeu a concorrência para a empresa Eppendorf. A reputação da Eppendorf, em especial, nos serviços de pós-vendas entre os pesquisadores brasileiros, contribuiu para que as instituições que sustentavam este mercado fossem redefinidas, notadamente a estrutura de governança e as normas das transações.
Pengaruh Pengembangan Karir dan Budaya Organisasi terhadap Kinerja Melalui Kepuasan Kerja Guru Sekolah Kebangsaan Kebun Sireh Pulau Pinang
Authors: Rusby Zulkifli , Hamzah Zulfadli
Published: June 2018

Human resource plays important role and the most dominant factors in organization. Employee performance can be measured by various indicators, one of which is job satisfaction. This research employs descriptive approach with collected primary and secondary data in describing the effect of carrier development and culture organization on teacher performance through job satisfaction. The population of this research include all teacher are 46 respondent. Data analysis technique use path analysis. The result of this research found that carrier development through job satisfaction indirectly has positive influence or significance toward teacher performance. Besides that, organizational culture through job satisfaction indirectly also has positive influence or significance toward teacher performance.

Keywords: Carrier Development,Organizational Culture,Performance,Job Satisfaction, Path Analysis
Hubungan Pola Makan dengan Kejadian Anemia pada Ibu Hamil di Wilayah Kerja Puskesmas
Authors: Mariana Dina , Wulandari Dwi , Padila Padila
Published: June 2018

This study aims to determine the relationship between diet and the incidence of anemia in pregnant women in Puskesmas Jalan Gedang Kota Bengkulu. Based on the preliminary study conducted on 10 people pregnant women in the work area of ​​gedang puskesmas got 5 mother mother had pregnancy anemia in trimester 1 and 2I, when asked this matter because of the food menu that potluck.The study method used was a descriptive analytic cross sectional design. This studywas conducted in Jalan Gedang health center Bengkulu City from March 1 until May 1, 2017, with the samples of 30 respondents. Retrieving data was done using a questionnaire sheet and documentation of patient status and then analyzed by univariate and bivariate using Chi Square test. Results of the 30 respondents were half of the respondents 50.0% had unhealthy eating patterns, almost half of respondents 26.7% had anemia. Based on Chi-Square test pvalue 0.035, which shows there was a correlation between the diet and the incidence of anemia among pregnant women in Jalan Gedang health center Bengkulu City.

Keywords: Anemia of Pregnant Women, Diet,
Risk of subsequent stroke, with or without extracranial-intracranial bypass surgery: a nationwide, retrospective, population-based study
Authors: Chen XianXiu , Lin Cheng-Li , Su Yuan-Chih , Chen Kuan-Fei , Lai Shih-Wei , Wei Sung-Tai , Peng Ching-Tien , Chiu Cheng-Di , Shieh Shwn-Huey , Chen Chun-Chung
Published: June 2018

OBJECTIVE

Although no benefits of extracranial-intracranial (EC-IC) bypass surgery in preventing secondary stroke have been identified previously, the outcomes of initial symptomatic ischemic stroke and stenosis and/or occlusion among the Asian population in patients with or without bypass intervention have yet to be discussed. The authors aimed to evaluate the subsequent risk of secondary vascular disease and cardiac events in patients with and without a history of this intervention.

METHODS

This retrospective nationwide population-based Taiwanese registry study included 205,991 patients with initial symptomatic ischemic stroke and stenosis and/or occlusion, with imaging data obtained between 2001 and 2010. Patients who underwent EC-IC bypass (bypass group) were compared with those who had not undergone EC-IC bypass, carotid artery stenting, or carotid artery endarterectomy (nonbypass group). Patients with any previous diagnosis of ischemic or hemorrhagic stroke, moyamoya disease, cancer, or trauma were all excluded.

RESULTS

The risk of subsequent ischemic stroke events decreased by 41% in the bypass group (adjusted hazard ratio [HR] 0.59, 95% CI 0.46–0.76, p < 0.001) compared with the nonbypass group. The risk of subsequent hemorrhagic stroke events increased in the bypass group (adjusted HR 2.47, 95% CI 1.67–3.64, p < 0.001) compared with the nonbypass group.

CONCLUSIONS

Bypass surgery does play an important role in revascularization of the ischemic brain, while also increasing the risk of hemorrhage in the early postoperative period. This study highlights the fact that the high risk of bypass surgery obscures the true benefit of revascularization of the ischemic brain and also emphasizes the importance of developing improved surgical technique to treat these high-risk patients.
Variations in 30-day readmissions and length of stay among spine surgeons: a national study of elective spine surgery among US Medicare beneficiaries
Authors: Singh Siddhartha , Sparapani Rodney , Wang Marjorie C.
Published: June 2018

OBJECTIVE

Pay-for-performance programs are targeting hospital readmissions. These programs have an underlying assumption that readmissions are due to provider practice patterns that can be modified by a reduction in reimbursement. However, there are limited data to support the role of providers in influencing readmissions. To study this, the authors examined variations in readmission rates by spine surgeon within 30 days among Medicare beneficiaries undergoing elective lumbar spine surgery for degenerative conditions.

METHODS

The authors applied validated ICD-9-CM algorithms to 2003–2007 Medicare data to select beneficiaries undergoing elective inpatient lumbar spine surgery for degenerative conditions. Mixed models, adjusting for patient demographics, comorbidities, and surgery type, were used to estimate risk of 30-day readmission by the surgeon. Length of stay (LOS) was also studied using these same models.

RESULTS

A total of 39,884 beneficiaries were operated on by 3987 spine surgeons. The mean readmission rate was 7.2%. The mean LOS was 3.1 days. After adjusting for patient characteristics and surgery type, 1 surgeon had readmission rates significantly below the mean, and only 5 surgeons had readmission rates significantly above the mean. In contrast, for LOS, the patients of 288 surgeons (7.2%) had LOS significantly lower than the mean, and the patients of 397 surgeons (10.0%) had LOS significantly above the mean. These findings were robust to adjustments for surgeon characteristics and clustering by hospital. Similarly, hospital characteristics were not significantly associated with readmission rates, but LOS was associated with hospital for-profit status and size.

CONCLUSIONS

The authors found almost no variations in readmission rates by surgeon. These findings suggest that surgeon practice patterns do not affect the risk of readmission. Likewise, no significant variation in readmission rates by hospital characteristics were found. Strategies to reduce readmissions would be better targeted at factors other than providers.
Clinical potential of meningioma genomic insights: a practical review for neurosurgeons
Authors: Karsy Michael , Azab Mohammed A. , Abou-Al-Shaar Hussam , Guan Jian , Eli Ilyas , Jensen Randy L. , Ormond D. Ryan
Published: June 2018

Meningiomas are among the most common intracranial pathological conditions, accounting for 36% of intracranial lesions treated by neurosurgeons. Although the majority of these lesions are benign, the classical categorization of tumors by histological type or World Health Organization (WHO) grade has not fully captured the potential for meningioma progression and recurrence. Many targeted treatments have failed to generate a long-lasting effect on these tumors. Recently, several seminal studies evaluating the genomics of intracranial meningiomas have rapidly changed the understanding of the disease. The importance of NF2 (neurofibromin 2), TRAF7 (tumor necrosis factor [TNF] receptor–associated factor 7), KLF4 (Kruppel-like factor 4), AKT1, SMO (smoothened), PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha), and POLR2 (RNA polymerase II subunit A) demonstrates that there are at least 6 distinct mutational classes of meningiomas. In addition, 6 methylation classes of meningioma have been appreciated, enabling improved prediction of prognosis compared with traditional WHO grades. Genomic studies have shed light on the nature of recurrent meningioma, distinct intracranial locations and mutational patterns, and a potential embryonic cancer stem cell–like origin. However, despite these exciting findings, the clinical relevance of these findings remains elusive. The authors review the key findings from recent genomic studies in meningiomas, specifically focusing on how these findings relate to clinical insights for the practicing neurosurgeon.
Traumatic brain injury in high versus low falls in young children and adolescents: a retrospective analysis
Authors: Bandte Angela , Püschel Klaus , Krajewski Kara
Published: June 2018

OBJECTIVE

So-called low falls are gaining interest in traumatology. To date, there are no studies on low versus high falls in the pediatric population. The aim of the current analysis was to characterize the symptoms, diagnostics, and injuries associated with high versus low falls and to examine the effect of fall height on injuries and outcome in the context of current guideline-based recommendations.

METHODS

After obtaining study approval from the local ethics committee, the authors reviewed the data for patients ages 5–17 years who had been consecutively treated at either hospital associated with the University Medical Center Hamburg in the period from January 2009 to August 2014 for diagnoses including traumatic brain injury (TBI). Retrospective analysis of the electronic patient charts was performed to obtain data on demographics; accident mechanism; initial neurological status with respect to consciousness, symptoms, and Glasgow Coma Scale score; radiological studies; diagnoses; length of stay; all intracranial procedures; and Glasgow Outcome Scale (GOS) score.

RESULTS

Sixty-five fall-related TBIs among 380 patients were identified; 26 patients fell from a height of 3 m or more and 28 fell from a height under 3 m (height undocumented in 11 cases). Patients who fell from ≥ 3 m were 22 times more likely than those who fell from < 3 m to undergo spiral CT studies in the emergency room (p = 0.05). In addition, there was a 7.4 times greater chance of undergoing cranial CT (p = 0.02). There were significantly more noncerebral injuries requiring surgery in patients who fell from ≥ 3 m versus those who fell from < 3 m (p = 0.007). There was no difference in the frequency of neurosurgical procedures performed between low and high groups. Follow-up ranged from 0 to 92 months (mean 12.5 months, median 0 months). There was no significant difference in good (GOS score 4–5) and poor (GOS score 1–3) outcomes between high and low falls (p = 0.208).

CONCLUSIONS

Low falls can be associated with intracranial hemorrhages requiring ICU monitoring and/or surgery. The authors encourage intensive monitoring and CT scans based on clinical presentation, not on fall height.
Development of synthetic simulators for endoscope-assisted repair of metopic and sagittal craniosynostosis
Authors: Eastwood Kyle W. , Bodani Vivek P. , Haji Faizal A. , Looi Thomas , Naguib Hani E. , Drake James M.
Published: June 2018

OBJECTIVE

Endoscope-assisted repair of craniosynostosis is a safe and efficacious alternative to open techniques. However, this procedure is challenging to learn, and there is significant variation in both its execution and outcomes. Surgical simulators may allow trainees to learn and practice this procedure prior to operating on an actual patient. The purpose of this study was to develop a realistic, relatively inexpensive simulator for endoscope-assisted repair of metopic and sagittal craniosynostosis and to evaluate the models’ fidelity and teaching content.

METHODS

Two separate, 3D-printed, plastic powder–based replica skulls exhibiting metopic (age 1 month) and sagittal (age 2 months) craniosynostosis were developed. These models were made into consumable skull “cartridges” that insert into a reusable base resembling an infant’s head. Each cartridge consists of a multilayer scalp (skin, subcutaneous fat, galea, and periosteum); cranial bones with accurate landmarks; and the dura mater. Data related to model construction, use, and cost were collected. Eleven novice surgeons (residents), 9 experienced surgeons (fellows), and 5 expert surgeons (attendings) performed a simulated metopic and sagittal craniosynostosis repair using a neuroendoscope, high-speed drill, rongeurs, lighted retractors, and suction/irrigation. All participants completed a 13-item questionnaire (using 5-point Likert scales) to rate the realism and utility of the models for teaching endoscope-assisted strip suturectomy.

RESULTS

The simulators are compact, robust, and relatively inexpensive. They can be rapidly reset for repeated use and contain a minimal amount of consumable material while providing a realistic simulation experience. More than 80% of participants agreed or strongly agreed that the models’ anatomical features, including surface anatomy, subgaleal and subperiosteal tissue planes, anterior fontanelle, and epidural spaces, were realistic and contained appropriate detail. More than 90% of participants indicated that handling the endoscope and the instruments was realistic, and also that the steps required to perform the procedure were representative of the steps required in real life.

CONCLUSIONS

Both the metopic and sagittal craniosynostosis simulators were developed using low-cost methods and were successfully designed to be reusable. The simulators were found to realistically represent the surgical procedure and can be used to develop the technical skills required for performing an endoscope-assisted craniosynostosis repair.