bluuebunny/crossref_metadata_2025 huggingface dataset:
Underwater Sydney
Authors: Falkner Inke , Turnbull John
Published: August 2019

Admired all over the world and loved by locals for its natural beauty, Sydney Harbour is enjoyed by thousands of people every day. But rarely do we look below the surface where, beneath all the hustle and bustle, lively communities go about their business. With underwater forests and gardens, hundreds of species of fish and thousands of invertebrates, Sydney is as colourful and diverse below the water as it is above!
Underwater Sydney celebrates Sydney’s incredible harbour and coast through eclectic stories and stunning underwater photography. It also explores the challenges the harbour is facing today after more than 200 years of coastal development and the role that marine science plays in maintaining the harbour’s health. Underwater Sydney will open your eyes to the rich marine life that makes the Sydney estuary and coast so special.
Interactive effect of nitrogen nutrition, nitrate reduction and seasonal variation on oxalate synthesis in leaves of Napier-bajra hybrid (Pennisetum purpureum × P. glaucum)
Authors: Goyal Meenakshi , Kaur Rupinder
Published: August 2019

Oxalate may cause hypocalcaemia or formation of urinary calculi in animals with prolonged grazing of Napier grass (Pennisetum purpureum) × pearl millet (bajra, P. glaucum) hybrid (NBH). We investigated the influence of nitrate metabolism, nitrogen (N) nutrition, N forms and seasonal variation on oxalate accumulation in leaves of NBH in a field experiment in Ludhiana, India. The experiment was a randomised block design with three N sources (nitrate, amide and ammonium), three application rates (50, 75 and 100 kg N/ha), four seasons (summer, monsoon, autumn, pre-winter) and three replicates. Applied N nutrition induced oxalate synthesis and activities of nitrate reductase (NR) and nitrite reductase (NiR) enzymes. A positive association of N nutrition with both oxalate accumulation and nitrate-reducing enzymes was found. Nitrate-N increased oxalate accumulation and NiR activity more than ammonium and amide. A differential effect of seasons on NR and NiR activities, as well as on oxalate accumulation, was observed. Among different harvest seasons, NR and NiR activities were positively associated with oxalate accumulation in summer and the monsoon season. These results suggest that N fertilisation, particularly in nitrate form, is associated with upregulation of nitrate-reducing enzymes, leading to oxalate accumulation in NBH leaves.
Impacts of land use on hydrodynamic properties and pore architecture of volcanic soils from the Mexican Highlands
Authors: Duwig C. , Prado B. , Tinet A.-J. , Delmas P. , Dal Ferro N. , Vandervaere J. P. , Denis H. , Charrier P. , Gastelum Strozzi A. , Morari F.
Published: August 2019

Volcanic soils are important resources because of their unique mineralogical and physical characteristics, and allophanic Andosols represent some of the world’s most fertile soils. However, their unique properties can be lost when cultivated. Most soils in the Central Valley, Mexico, are derived from volcanic materials. This valley encompasses one of the largest water supply systems in the world by volume, but is affected by soil degradation and deforestation. Sustainably managing volcanic soils requires understanding how land use affects their hydrodynamic properties. Gas adsorption and mercury intrusion porosimetry, water retention curves, tension infiltrometry and X-ray tomography were used to describe pore structure characteristics. Two volcanic soils (one Andosol and one derived from indurated tuff – Tepetates), three land uses (maize monoculture, maize–wheat rotation and fallow) and two horizons (Ap and A2 for maize monoculture and maize–wheat rotation) were studied. Tillage affected topsoil by increasing the sand fraction by 38% and decreasing total porosity and macroporosity by 23% and 40% respectively. Macropore size was reduced and the number of isolated macropores was higher in the tilled layer under maize, compared with untilled subsoil. The plot under maize–wheat rotation had lower allophane content, and saturated hydraulic conductivity was reduced by nearly an order of magnitude and water retention by half, compared with maize and fallow plots. Compared with Andosols, Tepetates showed differences in mineralogical composition with lower contents of amorphous compounds and in its porous network characteristics with twice the total and percolating macroporosity compared with the maize plot. Its high content of organic carbon (3.5%) seemed beneficial for its hydrodynamic properties. Sustainable agricultural management of these volcanic soils requires reducing mechanised tillage, avoiding periods when soil is bare, not applying maize–wheat rotation and applying maize–fallow rotation allowing natural vegetation growth.
Efficient fabrication of ultrafine-grained 316L stainless steel surfaces for orthopaedic applications
Authors: Tufan Yiğithan , Demir Eyüp Can , Efe Mert , Ercan Batur
Published: August 2019

Commonly used severe plastic deformation (SPD) methods are suitable for fabrication of bulk nano and ultrafine-grained metals. Drawbacks of these methods include durability of dies, geometrical restrictions and reduced ductility of the products. In this study, two common machining techniques used in manufacturing of orthopaedic components, turning and milling, were applied on 316L stainless steel as surface SPD to refine the surface microstructures of the workpiece. Machining with optimised parameters resulted in substantial grain refinement down to 98 nm on the surfaces. Biological experiments showed up to ∼70% and ∼280% increased bone cell density on milled and turned samples compared to conventionally machined 316L stainless steel at 5 days, which was correlated with nanocrystallisation and nanoroughness of the samples.
Reform narratives and argumentative coupling in German pension policy: constructing the ‘deserving retiree’
Authors: Blum Sonja
Published: August 2019

German pension policy experienced a shift in the early 2000s, when public pensions were cut back, the retirement age raised, and private, publicly subsidized pension provision stipulated. Within a coherent reform narrative, those reforms were grounded on arguments of a ‘demographic time bomb’, a no-longer-affordable public pension scheme, and the return potential of private pension funds. Yet this narrative was delegitimized quickly with zero-rate-policy, and increasing old-age poverty in a lean public pension scheme. In such a situation, it can be expected difficult to either adapt the old narrative or construct new ones. This makes an interesting case for this article to study reform narratives and argumentative coupling in recent German pension policy through two contrasting cases: A failed attempt at establishing a minimum-pension scheme; and a ‘successful’ reform package combining a ‘mothers’ pension’ and exceptions for a full pension at age 63. Findings illuminate how the contrasting success of those reform proposals can be understood in terms of narrative stories: The reform which – political-strategically – could build on the ‘deservingness’ of the target groups could be agreed upon comparatively easily. Possible beneficiaries of a minimum pension are of varying ‘deservingness’, though, and narrating a more ‘problem-solving’ story has proven difficult.
When words matter: narratives and strategies in the Italian Jobs Act (2014–2016)
Authors: Tullia Galanti Maria , Sacchi Stefano
Published: August 2019

With the reforms of the so-called ‘Jobs Act’ (JA), Italy aimed to structurally reform its labour market and income-support system, through recalibration (i.e. a mix of both expansionary and retrenching measures) for old social policy risks, and some expansionary measures to face new social risks. The JA also became the symbol of opposite views about the Italian welfare state, being itself a reason for ideological conflict and coalition reshuffling in the Italian left. Ultimately, its increasing personalization around Renzi’s divisive figure detracted from its functional and substantive matter. Hence, the JA reform provides an unparalleled vantage point to investigate the role of narrative stories in shaping policy contents and reforms. The paper aims to contribute to the literature on social policy reforms by combining a focus on narrative stories with the analytical perspective of the Multiple Stream Framework. Through qualitative analysis of official documents, of more than 500 newspaper articles and of selected in-depth interviews to key informants, this paper reconstructs the narratives about the JA reform, considering both the supporters and the challengers. Building on the Multiple Stream Framework, the paper focuses in particular on whether and how policy entrepreneurs took advantage of windows of opportunity by shaping the narrative stories. Results are twofold. First, the paper shows the variations of social policy reform narratives across actors. Second, it demonstrates the crucial role of policy entrepreneurs in shaping narrative stories as a strategy to couple the streams of problem, policy and politics.
Narrative stories in Chinese characters: political framing of ageing and welfare reform in China
Authors: Van Gerven Minna
Published: August 2019

This article analyses narrative stories used by the Chinese government to connect the problem of population ageing to welfare reform. The findings derived from semi-structural interviews and key policy documents suggest the unfolding of the narrative stories of power and stories of rising and stories of decline. The narrative stories in the developmental Chinese welfare state are diverse and stem from different processes than those for the mature European welfare states. The Narrative stories also vary for different policy areas. For inequality and health-care policies, under the master narrative of story of power, state depicts ‘stories of giving-to-give’ to support expansion in the traditional ‘old risk’ type of policies to main population, including the elderly. For long-term care, the power narrative of ’giving-to-shape’ legitimizes the expansionary reforms for a small group of deserving frail elderly. Behind this political framing of long-term care reform lies the story of decline that justifies the modest role of state provision in the organization of long-term care and leaves the responsibility for economic, social and spiritual wellbeing for the society itself. The story of decline in China also gravitates around sustainability of societies rather than around financial sustainability commonly underlining the political debate in the West.
Optoelectronic properties analysis of silicon light-emitting diode monolithically integrated in standard CMOS IC*
Authors: Chen Yanxu , Xu Dongliang , Xu Kaikai , Zhang Ning , Liu Siyang , Zhao Jianming , Luo Qian , Snyman Lukas W , Swart Jacobus W
Published: August 2019

Si

p

+

n

junction diodes operating in the mode of avalanche breakdown are capable of emitting light in the visible range of 400–900 nm. In this study, to realize the switching speed in the GHz range, we present a transient model to shorten the carrier lifetime in the high electric field region by accumulating carriers in both p and n type regions. We also verify the optoelectronic characteristics by disclosing the related physical mechanisms behind the light emission phenomena. The emission of visible light by a monolithically integrated Si diode under the reverse bias is also discussed. The light is emitted as spatial sources by the defects located at the p–n junction of the reverse-biased diode. The influence of the defects on the electrical behavior is manifested as a current-dependent electroluminescence.
Two-dimensional XSe2 (X= Mn, V) based magnetic tunneling junctions with high Curie temperature*
Authors: Pan Longfei , Wen Hongyu , Huang Le , Chen Long , Deng Hui-Xiong , Xia Jian-Bai , Wei Zhongming
Published: August 2019

Two-dimensional (2D) magnetic crystals have attracted great attention due to their emerging new physical phenomena. They provide ideal platforms to study the fundamental physics of magnetism in low dimensions. In this research, magnetic tunneling junctions (MTJs) based on XSe2 (X=Mn, V) with room-temperature ferromagnetism were studied using first-principles calculations. A large tunneling magnetoresistance (TMR) of 725.07% was obtained in the MTJs based on monolayer MnSe2. Several schemes were proposed to improve the TMR of these devices. Moreover, the results of our non-equilibrium transport calculations showed that the large TMR was maintained in these devices under a finite bias. The transmission spectrum was analyzed according to the orbital components and the electronic structure of the monolayer XSe2 (X=Mn, V). The results in this paper demonstrated that the MTJs based on a 2D ferromagnet with room-temperature ferromagnetism exhibited reliable performance. Therefore, such devices show the possibility for potential applications in spintronics.
Pasture-scale vegetation predicts Dickcissel nest-site selection and success in native and exotic grass pastures
Authors: Monroe Adrian P , Burger L Wes , Martin James A
Published: August 2019

Exotic grasses such as bermudagrass (Cynodon dactylon) and tall fescue (Schedonorus arundinaceus) are widely established across the southeastern United States as livestock forage, but their structure and management can limit avian reproductive success. Native warm-season grasses (NWSG) are promoted as sustainable forage alternatives. To examine nesting suitability for tall structure specialists such as Dickcissels (Spiza americana) we established an operational-scale study in northeastern Mississippi, USA, with 4 treatments along a gradient of beef production intensity. Treatments included grazed exotic forages, 2 grazed NWSG treatments including Indiangrass (Sorghastrum nutans) monoculture and NWSG polyculture of Indiangrass, little bluestem (Schizachyrium scoparium), and big bluestem (Andropogon gerardii), and an ungrazed NWSG polyculture treatment. We monitored 208 Dickcissel nests in 2011 and 2012 to evaluate effects of treatment, vegetation structure, fire ants (Solenopsis spp.), and arthropod prey biomass on nest-site selection and nest survival. Survival rates varied among treatments and increased with pasture-scale visual obstruction reading (VOR), being lowest among grazed exotic grass, intermediate in grazed NWSG, and highest in ungrazed NWSG. Although Dickcissels selected nest sites with greater VOR, we found little support for effects of nest-site vegetation on survival. However, nest survival was lower for nests in shrubs that also occurred in pastures with greater shrub cover, and selection for shrubs declined as pasture-scale VOR increased, suggesting a functional response in selection. We found little support for food availability influencing nest survival. These results suggest NWSG pastures increase Dickcissel nest success through greater pasture-scale VOR by reducing Dickcissel selection of shrubs for nest sites, and possibly by reducing predator efficiency. Incorporating NWSG into beef production systems while maintaining availability of tall vegetation could benefit Dickcissels and other tall structure specialists.
The Relationship between the European Court of Human Rights and the Constitutional Court of the Russian Federation: Conflicting Conceptions of Sovereignty in Strasbourg and St Petersburg
Authors: Kahn Jeffrey
Published: August 2019

Russia eagerly ratified the European Convention on Human Rights (ECHR) in 1998. Twenty years later, the chair of its Constitutional Court now expresses resentment at the subordination of Russian sovereignty. A new law expands his Court’s jurisdiction to deny effect to judgments of the European Court of Human Rights, an unprecedented power that has already been used twice. This article analyses this law and its application in its first two years. Both the claim of ‘subordination’ and the Russian response to it, in law and practice, rest on weak legal ground. But Russia’s action also raises deeper theoretical and practical questions for the ECHR as a ‘living instrument’ subject to the ‘evolutive’ interpretations of the Strasbourg Court. If other member states mimic Russia’s response to these issues, a European human rights system premised on the final interpretive authority of an international court could come to its end.
Interactions of anaerobic ammonium oxidizers and sulfide-oxidizing bacteria in a substrate-limited model system mimicking the marine environment
Authors: Russ Lina , van Alen Theo A , Jetten Mike S M , Op den Camp Huub J M , Kartal Boran
Published: August 2019

In nature anaerobic ammonium oxidation (anammox) and denitrification processes convert fixed nitrogen to gaseous nitrogen compounds, which are then released to the atmosphere. While anammox bacteria produce N2 from ammonium and nitrite, in the denitrification process nitrate and nitrite are converted to N2 and the greenhouse gas nitrous oxide (N2O). Furthermore, nitrite needed by the anammox bacteria can be supplied by nitrate reduction to nitrite. Consequently, the interplay between nitrogen-transforming microorganisms control the amount of harmless N2 or the greenhouse gas N2O released to the atmosphere. Therefore, it is important to understand the interactions of these microorganisms in the natural environment, where dynamic conditions result in fluctuating substrate concentrations. Here, we studied the interactions between the sulfide-oxidizing denitrifier Sedimenticola selenatireducens and the anammox bacterium Scalindua brodae in a bioreactor mimicking the marine environment by creating sulfide, ammonium and nitrate limitation in distinct operational phases. Through a microbial interaction, Se. selenatireducens reduced nitrate to nitrite, which together with the supplied ammonium was converted to N2 by Sc. Brodae. Using comparative transcriptomics, we determined that Sc. Brodae and Se. selenatireducens had significant responses to ammonium and nitrate limitation, respectively, indicating that the activities of these microorganisms are regulated by different nitrogen compounds.
Theorizing the Judicialization of International Relations
Authors: Alter Karen J , Hafner-Burton Emilie M , Helfer Laurence R
Published: August 2019

This article introduces a Thematic Section and theorizes the multiple ways that judicializing international relations shifts power away from national executives and legislatures toward litigants, judges, arbitrators, and other nonstate decision-makers. We identify two preconditions for judicialization to occur—(1) delegation to an adjudicatory body charged with applying designated legal rules, and (2) legal rights-claiming by actors who bring—or threaten to bring—a complaint to one or more of these bodies. We classify the adjudicatory bodies that do and do not contribute to judicializing international relations, including but not limited to international courts. We then explain how rights-claiming initiates a process for authoritatively determining past violations of the law, identifying remedies for those violations, and preventing future violations. Because judicializing international relations occurs in multiple phases, in multiple locations, and involves multiple actors as decision-makers, governments often do not control the timing, nature, or extent to which political and policy decisions are adjudicated. Delegation—and the associated choice of institutional design features—is thus only the first step in a chain of processes that determine how a diverse array of nonstate actors influence politically consequential decisions.
The Dejudicialization of International Politics?
Authors: Abebe Daniel , Ginsburg Tom
Published: August 2019

For many, the growing judicialization of international relations is the next step in the process toward the complete legalization of international politics. We draw on the literature in comparative judicial politics to examine the limits of the phenomenon. The domestic literature on judicialization portrays the process as something of a one-way ratchet. In an increasingly juridified world, judges have been asked to take on greater roles in global governance, and they seem to be doing so with aplomb. This in turn incentivizes individuals and interest groups to frame their policy claims in legal terms, providing ever-more fuel for judicial governance. Yet many courts and other legal institutions, both domestic and international, have had their jurisdiction constrained, with some areas of law removed from judicial purview. Might the dynamics of constraint and backlash lead to the dejuridification of an area that has been judicialized? We conceptualize the possibility of what we call dejudicialization, situate it in the context of the literature on backlash, and delimit its potential scope and implications. While dejudicialization is empirically rare, we argue that its very possibility suggests that judicialization should not be considered a teleological process.
Frequent Detection of Pituitary-Derived PrPres in Human Prion Diseases
Authors: Honda Hiroyuki , Matsumoto Masaki , Shijo Masahiro , Hamasaki Hideomi , Sadashima Shoko , Suzuki Satoshi O , Aishima Shinichi , Kai Keita , Nakayama Keiichi I , Sasagasako Naokazu , Iwaki Toru
Published: August 2019

Human prion diseases including sporadic Creutzfeldt-Jakob disease (sCJD), inherited prion diseases, and acquired human prion diseases are lethal neurodegenerative diseases. One of the major sources of iatrogenic Creutzfeldt-Jakob disease was human growth hormone (hGH-iCJD) derived from contaminated cadaveric pituitaries. The incidence of hGH-iCJD has decreased since changing from growth hormone extracted from human cadaveric pituitaries to recombinant pituitary hormones. However, extensive analysis on the localization and detecting of abnormal prion protein in the pituitary gland are limited. In this study, we examined 9 autopsied brains and pituitary glands from 6 patients with prion disease (3 Gerstmann-Sträussler-Scheinker disease, 2 sCJD, and 1 dura mater graft-associated CJD) and 3 individuals with nonprion diseases. Western blot analysis of pituitary samples demonstrated unique glycoforms of normal cellular prion protein with molecular weights of 30–40 kDa, which was higher than the typical 25–35 kDa prion protein in brains. Proteomic analysis also revealed prion protein approximately the molecular weight of 40 kDa in pituitary samples. Moreover, proteinase K-resistant Prion protein was frequently detected in pituitary samples of the prion diseases. Immunohistochemistry for Prion protein revealed mosaic cellular distribution preferentially in growth hormone- or prolactin-producing cells.
NGTS-6b: an ultrashort period hot-Jupiter orbiting an old K dwarf
Authors: Vines Jose I , Jenkins James S , Acton Jack S , Briegal Joshua , Bayliss Daniel , Bouchy François , Belardi Claudia , Bryant Edward M , Burleigh Matthew R , Cabrera Juan , Casewell Sarah L , Chaushev Alexander , Cooke Benjamin F , Csizmadia Szilárd , Eigmüller Philipp , Erikson Anders , Foxell Emma , Gill Samuel , Gillen Edward , Goad Michael R , Jackman James A G , King George W , Louden Tom , McCormac James , Moyano Maximiliano , Nielsen Louise D , Pollacco Don , Queloz Didier , Rauer Heike , Raynard Liam , Smith Alexis M S , Soto Maritza G , Tilbrook Rosanna H , Titz-Weider Ruth , Turner Oliver , Udry Stéphane , Walker Simon R , Watson Christopher A , West Richard G , Wheatley Peter J
Published: August 2019

We report the discovery of a new ultrashort period hot Jupiter from the Next Generation Transit Survey. NGTS-6b orbits its star with a period of 21.17 h, and has a mass and radius of $1.330^{+0.024}_{-0.028}$MJ and $1.271^{+0.197}_{-0.188}$RJ, respectively, returning a planetary bulk density of $0.711^{+0.214}_{-0.136}$ g cm−3. Conforming to the currently known small population of ultrashort period hot Jupiters, the planet appears to orbit a metal-rich star ([Fe/H] = +0.11 ± 0.09 dex). Photoevaporation models suggest the planet should have lost 5 per cent of its gaseous atmosphere over the course of the 9.6 Gyr of evolution of the system. NGTS-6b adds to the small, but growing list of ultrashort period gas giant planets, and will help us to understand the dominant formation and evolutionary mechanisms that govern this population.
Photospheric nitrogen abundances and carbon 12C/13C ratios of red giant stars
Authors: Takeda Yoichi , Omiya Masashi , Harakawa Hiroki , Sato Bun’ei
Published: August 2019

Nitrogen abundances and carbon isotope ratios (12C$/$13C) in the atmospheres of red giants are known to be influenced by dredge-up of H-burning products, and serve as useful probes to study the nature of evolution-induced envelope mixing. We determined the [N/Fe] and 12C$/$13C ratios for 239 late-G/early-K giant stars by applying the spectrum-fitting technique to the 12CN and 13CN lines in the ∼8002–8005 Å region, with the aim of investigating how these quantities are related to other similar mixing-affected indicators which were already reported in our previous work. It was confirmed that [N/Fe] values are generally supersolar (typically by several tenths of a dex, though widely differing from star to star), anti-correlated with [C/Fe], and correlated with [Na/Fe], as expected from theory. As seen from their dependence upon stellar parameters, it appears that mixing tends to be enhanced with an increase of stellar luminosity (or mass) and rotational velocity, which is also reasonable from the theoretical viewpoint. In contrast, the resulting 12C$/$13C ratios turned out to be considerably diversified in the range of ∼5–50 (with a peak around ∼20), without showing any systematic dependence upon C or N abundance anomalies caused by the mixing of CN-cycled material. It thus appears that our understanding of the photospheric 12C$/$13C ratios in red giants is still incomplete, requiring more observational studies.
Brief, one-on-one, telephone-adapted mindfulness-based stress reduction for patients undergoing percutaneous coronary intervention: a randomized controlled trial
Authors: Hou Yunying , Zhao Xin , Lu Minxia , Lei Xiaoqing , Wu Qing , Wang Xiaohua
Published: August 2019

Patients undergoing percutaneous coronary intervention showed significant psychological symptoms improvement when assigned to a brief on-on-one, telephone-adapted mindfulness-based stress reduction intervention.
Liver Inflammatory Injury Initiated by DAMPs-TLR4-MyD88/TRIF-NFκB Signaling Pathway Is Involved in Monocrotaline-Induced HSOS
Authors: Huang Zhenlin , Chen Minwei , Wei Mengjuan , Lu Bin , Wu Xiaojun , Wang Zhengtao , Ji Lili
Published: August 2019

Hepatic sinusoidal obstruction syndrome (HSOS) causes considerable morbidity and mortality in clinic. Up to now, the molecular mechanisms involved in the development of HSOS still remain unclear. Here, we report that hepatic inflammation initiated by damage-associated molecular patterns (DAMPs) plays a critical role in the development of HSOS. Monocrotaline (MCT) belongs to pyrrolizidine alkaloids. Monocrotaline-induced HSOS in mice and rats was evidenced by the increased serum alanine/aspartate aminotransferase (ALT/AST) activities, the elevated hepatic metalloproteinase 9 (MMP9) expression, and results from liver histological evaluation and scanning electron microscope observation. However, MCT-induced HSOS was markedly attenuated in myeloid differentiation primary response gene 88 (MyD88), TIR-domain-containing adapter-inducing interferon-β (TRIF) and toll like receptor 4 (TLR4) knock-out mice. Monocrotaline increased liver myeloperoxidase activity, serum contents of proinflammatory cytokines, hepatic aggregation of immune cells, and nuclear accumulation of nuclear factor κB (NFκB). However, these inflammatory responses induced by MCT were all diminished in MyD88, TRIF, and TLR4 knock-out mice. Monocrotaline elevated serum contents of DAMPs including high mobility group box 1 (HMGB1) and heat shock protein 60 (HSP60) both in mice and in rats. HSOS was markedly exacerbated and serum contents of HMGB1 and HSP60 were elevated in nuclear factor erythroid 2-related factor 2 (Nrf2) knock-out mice treated with MCT. Our findings indicate that hepatic inflammatory injury mediated by DAMPs-initiated TLR4-MyD88/TRIF-NFκB inflammatory signal pathway plays an important role in HSOS development.
Localized Genetic and Phenotypic Diversity of Xanthomonas translucens Associated With Bacterial Leaf Streak on Wheat and Barley in Minnesota
Authors: Curland Rebecca D. , Gao Liangliang , Hirsch Cory D. , Ishimaru Carol A.
Published: August 2019

Bacterial leaf streak (BLS) of wheat and barley has been a disease of increasing concern in the Upper Midwest over the past decade. In this study, intra- and interfield genetic and pathogenic diversity of bacteria causing BLS in Minnesota was evaluated. In 2015, 89 strains were isolated from 100 leaf samples collected from two wheat and two barley fields naturally infected with BLS. Virulence assays and multilocus sequence alignments of four housekeeping genes supported pathovar identifications. All wheat strains were pathogenic on wheat and barley and belonged to the same lineage as the Xanthomonas translucens pv. undulosa-type strain. All barley strains were pathogenic on barley but not on wheat. Three lineages of barley strains were detected. The frequency and number of sequence types of each pathovar varied within and between fields. A significant population variance was detected between populations of X. translucens pv. undulosa collected from different wheat fields. Population stratification of X. translucens pv. translucens was not detected. Significant differences in virulence were detected among three dominant sequence types of X. translucens pv. undulosa but not those of X. translucens pv. translucens. Field trials with wheat and barley plants inoculated with strains of known sequence type and virulence did not detect significant race structures within either pathovar. Knowledge of virulence, sequence types, and population structures of X. translucens on wheat and barley can support studies on plant–bacterial interactions and breeding for BLS disease resistance.
Choroid plexus APP regulates adult brain proliferation and animal behavior
Authors: Arnaud Karen , Moreira Vanessa Oliveira , Vincent Jean , Dallerac Glenn , Le Poupon Chantal , Richter Max , Müller Ulrike C. , Rondi-Reig Laure , Prochiantz Alain , Di Nardo Ariel A.
Published: August 2019

Elevated amyloid precursor protein (APP) expression in the choroid plexus suggests an important role for extracellular APP metabolites in cerebrospinal fluid. Despite widespreadAppbrain expression, we hypothesized that specifically targeting choroid plexus expression could alter animal physiology. Through various genetic and viral approaches in the adult mouse, we show that choroid plexus APP levels significantly impacted proliferation in both subventricular zone and hippocampus dentate gyrus neurogenic niches. Given the role of Aβ peptides in Alzheimer disease pathogenesis, we also tested whether favoring the production of Aβ in choroid plexus could negatively affect niche functions. After AAV5-mediated long-term expression of human mutatedAPPspecifically in the choroid plexus of adult wild type mice, we observe reduced niche proliferation, behavioral defects in reversal learning, and deficits in hippocampal long-term potentiation. Our findings highlight the unique role played by the choroid plexus in regulating brain function, and suggest that targeting APP in choroid plexus may provide a means to improve hippocampus function and alleviate disease-related burdens.
SGID: a comprehensive and interactive database of the silkworm
Authors: Zhu Zhenglin , Guan Zhufen , Liu Gexin , Wang Yawang , Zhang Ze
Published: August 2019

Although the domestic silkworm (Bombyx mori) is an important model and economic animal, there is a lack of comprehensive database for this organism. Here, we developed the silkworm genome informatics database, SGID. It aims to bring together all silkworm related biological data and provide an interactive platform for gene inquiry and analysis. The function annotation in SGID is thorough and covers 98% of the silkworm genes. The annotation details include function description, gene ontology, KEGG, pathway, subcellular location, transmembrane topology, protein secondary/tertiary structure, homologous group and transcription factor. SGID provides genome scale visualization of population genetics test results based on high depth resequencing data of 158 silkworm samples. It also provides interactive analysis tools of transcriptomic and epigenomic data from 79 NCBI BioProjects. SGID is freely available athttp://sgid.popgenetics.net. This database will be extremely useful to silkworm research in the future.
Can Bitcoin become money? The monetary rule problem
Authors: Cachanosky Nicolás
Published: August 2019

The growing literature on Bitcoin can be divided into two groups. One performs an economic analysis of Bitcoin focusing on its monetary characteristics. The other one takes a financial look at the price of Bitcoin. Interestingly, both of these groups have not given much more than passing comments to the problem of whether or not Bitcoin has the right monetary rule in order to become a well‐established currency. This paper argues that Bitcoin in particular, and cryptocurrencies in general, do not have a good monetary rule and that this shortcoming seriously limits its prospect of becoming widely used money.
Geographic variation in the use of lymphadenectomy and external‐beam radiotherapy for endometrial cancer: a cross‐sectional analysis of population‐based data
Authors: White B , Nordin A , Fry A , Ahmad A , McPhail S , Roe C , Rous B , Smittenaar R , Shelton J
Published: August 2019

Objective

To quantify geographic variation in the use of lymphadenectomy and/or external‐beam radiotherapy (EBRT) for endometrial cancer in England.

Design

Cross‐sectional analysis of population‐based data.

Setting

English cancer registry data, linked to chemotherapy, radiotherapy and hospital episodes statistics data.

Population

Twenty‐two thousand four hundred and eighty‐three women with endometrial cancer presenting without clinical or radiological evidence of distant metastatic spread, diagnosed in England from 2013 to 2016.

Methods

Proportions of patients receiving lymphadenectomy and/or EBRT were compared across 19 Cancer Alliances, to identify variations in clinical practice. Two separate logistic regression models assessed the impact on variation of adjustment for tumour and patient characteristics.

Main outcome measures

Receipt of lymphadenectomy, receipt of EBRT.

Results

There was substantial variation by Cancer Alliance in the adjusted proportion of women with endometrial cancer receiving lymphadenectomy (range 5% [95% CI 4–6%] to 48% [95% CI 45–52%]) and EBRT (range 10% [95% CI 7–12%] to 31% [95% CI 28–33%]), after adjusting for variation in pathological grade, age, comorbidities, deprivation, ethnic group and (EBRT only) FIGO stage. Different approaches to clinical practice were identified; (i) one Cancer Alliance had significantly higher than average lymphadenectomy and significantly lower than average EBRT use, (ii) three had high use of both lymphadenectomy and EBRT, (iii) one had low lymphadenectomy use and high EBRT use, and (iv) three had low use of both lymphadenectomy and EBRT.

Conclusions

Lymphadenectomy is probably used to triage for EBRT when lymphadenectomy use is high and EBRT use is low. This is probably a result of variation in local endometrial cancer management guidelines, suggesting that UK recommendations should be clarified.

Tweetable abstract

There is geographic variation in England in the use of lymphadenectomy and radiotherapy to treat endometrial cancer.
The “sequential cues hypothesis”: a conceptual model to explain host location and ranking by polyphagous herbivores
Authors: Silva Rehan , Clarke Anthony R.
Published: August 2019

Successfully locating a host plant is crucial for an insect herbivore to feed and/or oviposit. However, locating a host within a complex environment that may contain an array of different plant species is a difficult task. This is particularly the case for polyphagous herbivores, which must locate a host within environments that may simultaneously contain multiple suitable and unsuitable hosts. Here we review the mechanisms of host selection used by polyphagous herbivores, as well as exploring how prior experience may modify a generalist's response to host cues. We show that recent research demonstrates that polyphagous herbivores have the capacity to detect both common cues from multiple host species, as well as specific cues from individual host species. This creates a paradox in that generalists invariably rank hosts when given a choice, a finding at odds with the “neural limitations” hypothesis that says generalist insect herbivores should not have the neural capacity to identify cues specific to every possible host. To explain this paradox we propose a model, akin to parasitoid host location, that postulates that generalist herbivores use different cues sequentially in host location. We propose that initially common host cues, associated with all potential hosts, are used to place the herbivore within the host habitat and that, in the absence of any other host cues, these cues are sufficient in themselves to lead to host location. As such they are true “generalist” cues. However, once within the host habitat, we propose that the presence of a smaller group of cues may lead to further host searching and the location of preferred hosts: these are “specialist” cues. This model explains the current conflict in the literature where generalists can respond to both common and specific host‐plant cues, while also exhibiting specialist and generalist host use behavior under different conditions.
Mung Bean Protein Hydrolysate Modulates the Immune Response Through NF‐κB Pathway in Lipopolysaccharide‐Stimulated RAW 264.7 Macrophages
Authors: Diao Jingjing , Chi Zhiping , Guo Zengwang , Zhang Liping
Published: August 2019

The objective of this study was to evaluate the immunomodulatory activity of mung bean protein hydrolysate (MBPH) in lipopolysaccharide (LPS)‐induced RAW 264.7 cells and discuss the possible immune regulatory mechanism. MBPH was prepared by alcalase, trypsin, neutrase, and flavourzyme. The 3‐h alcalase‐hydrolyzed hydrolysate with a molecular weight less than 1,450 Da was selected for the immunological tests. Results showed that MBPH possessed strong suppressing activity to proinflammatory mediators in a dose‐dependent manner. Compared to the LPS alone group, MBPH (200 µg/mL) significantly reduced nitric oxide (NO), inducible nitric oxide synthase, interleukin (IL)‐6, and IL‐1β secretion levels by 52.6%, 53.2%, 48.4%, and 49.7%, respectively, in LPS‐induced macrophages. It also enhanced IL‐10 secretion from 789 to 3,678 pg/mL. MBPH blocked nuclear factor‐kappa B (NF‐κB) translocation in LPS‐induced macrophages through the prevention of IκBα phosphorylation, and this process further prevented p65 translocation into the nucleus. A possible mechanism of MBPH is that it regulated the expression of inflammatory factors via the NF‐κB pathway, thus inhibiting inflammatory reactions. The results suggested that MBPH is of application potential in the development of immunomodulatory functional food to ameliorate immunosuppression.
Wheat Qu and Its Production Technology, Microbiota, Flavor, and Metabolites
Authors: Zhang Kaizheng , Li Qiong , Wu Wenchi , Yang Jiangang , Zou Wei
Published: August 2019

Chinese rice wine (CRW) is an ancient wine with a moderate alcohol content; it has been prized in China for its color, sweet flavor profile, and is a national beverage typically used in banquets. Wheat Qu is the starter used to make CRW, and plays a vital role in the quality and flavor profile. This review details the raw materials and the wheat Qu manufacturing process, and recent information on wheat Qu microbiotas. The volatile compounds in wheat Qus and its flavor are also reviewed. Finally, the enzymes, and metabolites contained in wheat Qu, such as biogenic amines, are also discussed.
Optimizing the genetic composition of a translocation population: Incorporating constraints and conflicting objectives
Authors: Bragg Jason G. , Cuneo Peter , Sherieff Ahamad , Rossetto Maurizio
Published: August 2019

Translocations of threatened species can reduce the risk of extinction from a catastrophic event. For plants, translocation consists of moving individuals, seeds, or cuttings from a native (source) population to a new site. Ideally a translocation population would be genetically diverse and consist of fit founding individuals. In practice, there are challenges to designing such a population, including constraints on the availability of material, and tradeoffs between different goals. Here, we present an approach for designing a translocation population that identifies sets of founders that are optimized according to multiple criteria (e.g., genetic diversity), while also conforming to constraints on the representation of different founders (e.g., propagation success). It uses flexible inputs, including SNP genotypes, matrices of similarity between individuals, and vectors of phenotype data. We apply the approach to a critically endangered plant,Hibbertia puberulasubsp.glabrescens(Dilleniaceae), which was genotyped at thousands of SNP loci. The goals of minimizing genetic similarity among the founding individuals and maximizing genetic diversity were largely complementary: populations optimized for one of these criteria were near‐optimal for the other. We also performed analyses in which we minimized genetic similarity among founding individuals while imposing selection (against hypothetical deleterious alleles, and against undesirable phenotypes, respectively), and here characterized sharp tradeoffs. This was useful in allowing the benefits of selection to be weighed against costs in terms of genetic similarity. In summary, we present an approach for designing a translocation population that allows flexible inputs, the imposition of realistic constraints, and examination of conflicting goals.
Effective Orchestration? The 1540 Committee and theWMDTerrorism Regime Complex
Authors: Kienzle Benjamin
Published: August 2019

In 2004, the United Nations Security Council adopted Resolution 1540, the central international tool to prevent terrorism with Weapons of Mass Destruction (WMD). In spite of the resolution's strong mandate, its implementation body, the 1540 Committee, has remained weak in terms of enforcement powers, budget allocation and human resources. This article addresses this gap between mandate and implementation capacity. It examines specifically how the 1540 Committee has tried to overcome its structural constraints to achieve its objectives. This has led to two important findings: first, building upon theoretical insights from the management of regime complexes, the article shows that the 1540 Committee has resorted to the orchestration of intermediary actors in the form of other international organizations belonging to the so‐calledWMDterrorism regime complex. This demonstrates that – contrary to what the current literature suggests – orchestration is used on a large scale in high profile cases of international security. Second, the analysis of the performance of the process of orchestration reveals significant variation. While a large number of intermediary actors have integrated the provisions of Resolution 1540 in their own agendas, the coordination of these actors by the 1540 Committee has remained largely ad hoc and lacked the systematic exchange of relevant information.
The impact of sealer extrusion on endodontic outcome: A systematic review with meta‐analysis
Authors: Aminoshariae Anita , Kulild James C.
Published: August 2019

The purpose of this systematic review was to qualify and quantify the evidence regarding the effect of extruded sealers on endodontic treatment outcomes. Two reviewers independently conducted a comprehensive literature search. The EMBASE, MEDLINE, Cochrane, PubMed databases, bibliographies, grey literature of all relevant articles and textbooks were searched. Six articles met the inclusion criteria with a moderate risk of bias and were analysed for qualitative and quantitative synthesis. There was moderate‐certainty evidence that sealer extrusion can contribute to non‐healing outcomes, 95% confidence interval, risk ratio 1.32 (1.12–1.54) and P < 0.05. This indicates that the current authors are somewhat confident the true effect is likely to be close to the estimate of the effect. Sealer extrusion had a 32% higher risk of contributing to a non‐healing outcome than no extrusion. However, well‐conducted research would need to be conducted to confirm this causality claim.
Impact of a Patient Blood Management monitoring and feedback programme on allogeneic blood transfusions and related costs
Authors: Kaserer A. , Rössler J. , Braun J. , Farokhzad F. , Pape H.‐C. , Dutkowski P. , Plass A. , Horisberger T. , Volbracht J. , Manz M. G. , Spahn D. R.
Published: August 2019

A Patient Blood Management programme was established at the University Hospital of Zurich, along with a monitoring and feedback programme, at the beginning of 2014 with a first analysis reported in 2015. Our study aimed to investigate the further impact of this Patient Blood Management monitoring and feedback programme on transfusion requirements and related costs. We included adult patients discharged between 2012 and 2017. A total of 213,882 patients underwent analysis: 66,659 patients in the baseline period (2012–2013); 35,309 patients in the year after the introduction of the Patient Blood Management monitoring and feedback programme (2014) and 111,914 patients in the continued sustainability period (2015–2017). The introduction of the Patient Blood Management monitoring and feedback programme reduced allogeneic blood product transfusions by 35%, from 825 units per 1000 hospital discharges in 2012 to 536 units in 2017. The most sustained effect was an approximately 40% reduction in red blood cell transfusions, from 535 per 1000 discharges to 319 units. Fewer patients were transfused in the periods after the introduction of the Patient Blood Management monitoring and feedback programme (6251 (9.4%) vs. 2932 (8.3%) vs. 8196 (7.3%); p < 0.001). Compared with 2012, the yearly OR for being exposed to any blood transfusion declined steadily after the introduction of the Patient Blood Management monitoring and feedback programme to 0.64 (95%CI 0.61–0.68; p < 0.001) in 2017. For patients requiring extracorporeal membrane oxygenation, transfusion requirements were also sustainably reduced. This reduction in allogeneic blood transfusions led to savings of 12,713,754 Swiss francs (£ 9,497,000 sterling; EUR 11,100,000; US$ 12,440,000) in blood product acquisition costs over 4 years. In‐hospital mortality was not affected by the programme. The Patient Blood Management monitoring and feedback programme sustainably reduced transfusion requirements and related costs, without affecting in‐hospital mortality.