bluuebunny/crossref_metadata_2025 huggingface dataset:
КОНЦЕПЦІЯ ПРОФЕСІЙНОЇ ПІДГОТОВКИ МАЙБУТНІХ ФАХІВЦІВ З ФІЗИЧНОЇ РЕАБІЛІТАЦІЇ ДО ФОРМУВАННЯ ЗДОРОВ’ЯЗБЕРЕЖУВАЛЬНОГО ОСВІТНЬОГО СЕРЕДОВИЩА
Authors: БЄЛКОВА Тетяна
Published: December 2024

У статті окреслено передумови створення концепції професійної підготовки майбутніх фахівців з фізичної реабілітації до формування здоров’язбережувального освітнього середовища: сучасні процеси становлення демократичної, правової, соціальної держави, розвиток засад громадянського суспільства, інтеграції України до Європейського співтовариства, реалізації освітньої реформи; спрямованість сучасної політики нашої держави у сфері реабілітації на збереження та оздоровлення нації. Метою створення концепції професійної підготовки майбутніх фахівців з фізичної реабілітації до формування здоров’язбережувального освітнього середовища є задоволення індивідуальних потреб здобувачів закладу вищої освіти щодо особистісного та професійного зростання за фахом, а також задоволення потреб держави у кваліфікованих спеціалістах з високим рівнем професіоналізму, здатних грамотно та відповідально проводити оздоровчу та реабілітаційну роботу з різним контингентом населення, впроваджувати в освітній процес здоров’язбережувальні та інтерактивні технології, сприяти гармонійному розвитку особистості, формуванню життєво необхідних навичок, розвитку фізичних якостей, зміцненню здоров’я та підготовці людини з обмеженими можливостями до активної трудової діяльності. Розкрито структуру та зміст професійної підготовки майбутніх фахівців з фізичної реабілітації, передбачено організаційні заходи щодо підвищення якості життя особистості шляхом максимального відновлення функціональних рухових можливостей. Запропоновано шляхи та наведено очікувані результати реалізації Концепції. Реалізація Концепції сприятиме створенню єдиного освітнього простору, спрямованого на забезпечення процесу професійної підготовки компетентного фахівця сфері реабілітації нового покоління, підготовленого до здійснення здоров’язбережувальної діяльності та конкурентоспроможного на ринку оздоровчо-реабілітаційних послуг.
Міжнародні та європейські стандарти у сфері цивільного та кримінального судочинства : матер. І Всеукр. наук.-практ. інтернет-конф. (м. Миколаїв, 28 березня 2024 р.)
Authors:   Національний університет «Одеська юридична академія» Миколаївський навчально-науковий інститут права Національного університету «Одеська юридична академія»
Published: December 2024

До збірника ввійшли тези доповідей, які оприлюднені під час І Всеукраїнської науково-практичної інтернет-конференції, присвяченої проблемам міжнародних та європейських стандартів у сфері цивільного та кримінального судочинства в умовах поєднаня особливостей загально-теоретичного та практичного правового напрямів
зазначеної тематики, зокрема: виствітлено окремі принципи цивільного судочинства; досліджено юрисдикцію спорів із приводу отримання, продовження, припинення дії
ліцензії; проаналізовано проблемні аспекти реалізації принципу змагальності господарського процесу; розглянуто питання доступності мови кримінального закону як
складової правової визначеності в контексті аналізу національної та європейської практики; вивчено окремі аспекти діджиталізації кримінального судочинтсва в контексті
досвіду Європейського Союзу; проаналізовано питання електронного адміністрування податкових процесів та ін. Отже, запропонована тематика доповідей і видання може бути корисним поштовхом для досліджень учених, аспірантів, магістрантів і студентів, співробітників судових та правоохоронних органів, органів публічної адміністрації, а також усіх, хто вивчає актуальну проблематику українського права, порівняно з нормами європейського права та процесу, практики його застосування, в умовах воєнного стану в Україні.
Hypersensitivity to chemotherapeutic drugs for the treatment of neoplasms. Literature review
Authors: Zaikov S.V. , Lykova M.A. , Hritsova N.A. , Veselovsky L.V.
Published: December 2024

BACKGROUND. Like any other drug, chemotherapy drugs can cause hypersensitivity reactions and are the third leading cause of drug-induced anaphylaxis deaths in the United States. Timely detection of hypersensitivity reactions to chemotherapeutic drugs in oncology is extremely important because, unlike other drugs (for example, antibiotics or anesthetics), which can be relatively easily replaced by others, chemotherapeutic drugs are often unique and indispensable for the treatment of neoplasms. In such situations, the doctor should evaluate the benefits of continuing treatment in comparison with the risk of a potentially fatal anaphylactic reaction when continuing chemotherapy with the drug that caused the development of hypersensitivity reactions, and also look for the possibility of replacing the chemotherapeutic drug that has become an allergen with another one.
OBJECTIVE. Analysis of existing data on the etiology, pathogenesis, clinic, diagnosis and prevention of hypersensitivity reactions associated with chemotherapy drugs for the treatment of neoplasms.
MATERIALS AND METHODS. Search for available sources of information, their analytical processing and discussion of the obtained results.
RESULTS. To date, there is a lack of data and research on approaches to the diagnosis and treatment of patients with neoplasms and hypersensitivity reactions to chemotherapy drugs. Cases of hypersensitivity reactions to chemotherapeutic drugs require the creation of a multidisciplinary team consisting of allergists, oncologists and therapists to choose rational tactics for managing such patients. For the diagnosis of hypersensitivity reactions to chemotherapeutic drugs, the clinical and anamnestic method, skin, laboratory and, if necessary, provocation tests with drugs should be used. Inorder to treat and prevent the development of hypersensitivity reactions to chemotherapeutic drugs, premedication with corticosteroids and antihistamines, replacement of the allergen drug, and in case of impossibility of such replacement, desensitization with the allergen drug should be used.
CONCLUSIONS. The problem of the development of hypersensitivity reactions to chemotherapeutic drugs used for the treatment of patients with neoplasms is extremely important and requires further research.
Polypharmacy among patients with asthma
Authors: Opimakh S.G.
Published: December 2024

ABSTRACT. Medical interventions are intended to benefit patients, but they can be threatening. Polypragmasia (problematic polypharmacy) is the inappropriate use of multiple medications or duplicate medications. Appropriate polypharmacy is the rational necessary and justified use of several drugs (5 or more) for the treatment of several concomitant diseases. Risk factors for polypragmasia include polymorbidity, advanced age, self-medication, and others. All these factors are inherent in bronchial asthma. Problematic polypharmacy in asthma is caused, among other, by the excessive use of salbutamol, which characterizes by a wide range of drug-drug interactions. Medications implicated in polypharmacy in asthmatics include asthma medications, antihistamines, anti-infective, cardiovascular agents, antidiabetics, gastrointestinal, anticonvulsants, antidepressants, antipsychotics, anxiolytics, sedatives, hypnotics, contraceptives and analgesics. Drugs that have a negative impact on the course of asthma in patients with comorbidities are angiotensin-converting enzyme inhibitors, proton pump inhibitors, antipsychotics and antibiotics. Problematic polypharmacy (polypragmasia) needs correction. Tackling problematic polypharmacy requires tailoring the use of medicines to individual circumstances and may involve the process of deprescribing. Deprescribing can cause anxiety and concern for clinicians and patients. An optimal approach for targeting patients with problematic polypharmacy is yet to be determined.
Amphibians and reptiles from Leyte Sab-a Basin Peatland: A unique wetland habitat in Leyte, Philippines
Authors: Decena Syrus Cesar P. , Banado Francis Ian C. , Densing Libertine Agatha F.
Published: December 2024

The Leyte Sab-a Basin Peatland (LSBP) is a unique wetland ecosystem that is an important refuge for biodiversity. However, the diversity of wildlife communities in peatland ecosystems, particularly herpetofauna (amphibians and reptiles), remains poorly understood. Therefore, the present study provides preliminary accounts of herpetofauna's occurrence, endemicity, habitat, and microhabitat use in LSBP. The field surveys in the peatland have yielded 39 herpetofauna species, comprising 13 frogs, 13 lizards, 12 snakes, and one turtle. Records from a previous study revealed a total of 44 herpetofauna species known to occur in peatland. A threatened species documented in the peatland is the Mindanao Fanged Frog (Limnonectes magnus Stejneger), which is already classified as near threatened based on the IUCN Red List of Threatened Species. The overall herpetofaunal endemicity was 64%, with an endemicity of 61% and 65% for amphibians and reptiles, respectively. The majority (69%) of the amphibian species occurred within the peatland area (peat swamp forests, grassland, and agricultural areas), while almost all (92%) of the reptile species were at least utilizing peatland edge/ecotone habitats. Around 43% of the amphibian species, mainly from the family Dicroglossidae, utilized terrestrial and aquatic microhabitats. For reptile species, a comparable portion of 46% utilized arboreal and terrestrial microhabitats. Lastly, it is crucial to implement conservation measures towards the unique ecology/biology of the herpetofauna species and the habitat dynamics in the peatland.
Encouraging the electrification of road transport at the regional level by creating an appropriately designed logistics centre
Authors: Schein Péter , Skapinyecz Róbert
Published: December 2024

The purpose of this paper is to examine how the more intensive electrification of urban and regional freight transport could be promoted with the help of a logistics centre to be created specifically for this purpose. Electrification requires more and more attention to make the transport of goods sustainable and to reduce harmful emissions. Besides, the advantages of electric freight transport can be, for example, the lighter regulations for electric cars and the tender resources that can be used for their purchase. However, while the technological capabilities of electric road freight transport vehicles are rapidly evolving careful infrastructural planning and expansion are still required to aid their wider adoption. For electric goods transport to be realized in an efficient way, the location of a possible logistics centre in the examined region – the city of Miskolc and its surroundings – is presented, based on the analysis of the local infrastructural conditions.
Micromobility revolution : Recommending efficient restaurant delivery systems in Hungary and Kyrgyzstan
Authors: Veres Péter , Umetaliev Akylbek , Bányai Tamás , Gombár Boglárka , Tamás Péter
Published: December 2024

The transportation systems of modern cities face growing challenges due to increasing populations and urbanization, resulting in reduced efficiency, heightened air pollution, and significant environmental strain. Micromobility solutions, such as electric bicycles and scooters, have emerged as effective and sustainable alternatives, offering reduced emissions and promoting the efficient use of resources. This study expands on the concept and applications of micromobility, particularly its role in logistics, with a focus on the "last mile" concept. This critical segment of the logistics chain emphasizes optimizing the final phase of delivery processes, illustrated here through a route planning analysis from the perspective of a fast-food delivery courier, incorporating the consolidation of purchasing and utility costs for various delivery methods. To deepen the understanding of micromobility's impact, this research includes a comparative case study conducted in Miskolc, Hungary, and Bishkek, Kyrgyzstan. The analysis examines the distinct urban contexts of these cities, assessing the efficiency, environmental benefits, and practical applications of micromobility solutions in their respective restaurant delivery ecosystems.
Application Of Variation Translation Theory In The Translation Of Culture-Loaded Words
Authors: Yuhe Meng
Published: December 2024

This paper explores the application of variation translation theory in the translation of culture-loaded words. It analyzes the challenges faced in translating such words and demonstrates how variation translation theory provides effective solutions. Through a comprehensive literature review, detailed methodology, analysis of results, and conclusive discussions, this study highlights the significance and relevance of applying variation translation theory in enhancing cross-cultural communication.
Nemzetközi nagyvállalatok helyi egységeinek hatásai Komárom-Esztergom vármegye gazdaságára
Authors: Peredy Zoltán , Péli László
Published: December 2024

Az elmúlt három évtizedben Komárom-Esztergom vármegye (KEM) a feldolgozóipar különböző szegmenseiben tevékenykedő nemzetközi nagyvállalatok kapacitás létesítő, bővítő és technológiai korszerűsítő első, második és harmadik körös kelet-és közép európai beruházási döntései során preferált térséggé vált a kedvező feltételek és profitkilátások miatt. A szerzők egy szélesebb körű kutatás keretében, amelynek célja a KEM feldolgozóiparának szélesebb körű regionális elemzése jelen tanulmányukban azt elemzik, hogy a nemzetközi nagyvállalatok helyi egységei által megtermelt hozzáadott értéknek (GVA) és az általuk foglalkoztatott helyi munkaerőnek milyen hatásai vannak a vármegye gazdaságára, illetve ezen egységek termelékenysége hogyan viszonyul a vármegye átlagos termelékenységéhez. Emellett kitérnek arra is, hogy ezen feldolgozóipari beruházások által generált gazdasági növekedés és fejlődés átmenetei-e vagy tartós, azaz elkerülhető-e a KEM-ben a feldolgozóipari megyékre általában jellemző centrum-periféria fejlődési csapda helyzet. A feldolgozóipari térségek magas GVA aránya, alacsony hozzáadott értékű tevékenységei és alacsony termelékenysége miatt a beruházások jelentette gazdasági fellendülés átmeneti és a későbbiekben visszaesés várható, ami az ország fejlődését is visszafogja. Hogyan lehet ezt a csapdahelyzetet elkerülni a KEM-ben, az elmúlt időszakban megindult dinamikus gazdasági fejlődést fenntarthatóvá tenni és ehhez milyen gazdaságstratégiai irányváltás szükséges.
Innováció a mezőgazdaságban: irodalmi kitekintés
Authors: Vargáné Dudás Piroska , Szabó-Szentgróti Gábor
Published: December 2024

Ez a tanulmány összefoglalja az önvezető járművek ígéretes lehetőségeit és kihívásait a mezőgazdaságban. A további kutatás és fejlesztések révén ezek a technológiák lehetővé tehetik a fenntarthatóbb, hatékonyabb és versenyképesebb mezőgazdasági gyakorlatokat a jövőben. Az átalakító technológia elfogadását és bevezetését befolyásoló tényezők megértésére összpontosítva elmélyedünk a gazdákra, az iparági érdekeltekre és a fenntartható mezőgazdaság jövőjére gyakorolt hatásokban. Ipar 4.0, önvezető traktorok, autonóm járművek, mezőgazdasági traktorok, automatizált mezőgazdaság kulcsszavakat használva, készült a szakirodalmi áttekintés azzal a céllal, hogy átfogó képet kapjunk az önvezető traktorok használatáról hazai és nemzetközi szinten, továbbá betekintést nyerjünk az Ipar 4.0 és a mesterséges intelligencia hatására a mezőgazdaságban. Megismerjük az önvezető traktorokat és az Ipar 4.0 esetleges veszélyeit a mezőgazdaságban. Gazdálkodói szinten az önvezető traktorok átvétele paradigmaváltást jelent a mezőgazdasági feladatok végrehajtásában. Alapvető fontosságú az egyes gazdálkodókra gyakorolt hatások megértése, ideértve a munkakörben bekövetkezett változásokat, a szükséges készségeket és a lehetséges társadalmi-gazdasági hatásokat. Az autonóm technológia bevezetése megváltoztathatja a hagyományos gazdálkodási gyakorlatokat, így képzési programokra és támogatási mechanizmusokra lesz szükség a gazdálkodók számára, hogy zökkenőmentesen alkalmazkodjanak az új technológiai környezethez. Létfontosságú annak feltárása, hogy ez az átmenet hogyan befolyásolhatja az egyéni gazdálkodók megélhetését, jólétét és autonómiáját, biztosítva, hogy az önvezető traktorok előnyei méltányosak és inkluzívak legyenek.
Módszertan hőszivattyú kültéri egységének hőmérsékleti viszonyainak mérésére
Authors: Hermanucz Péter , Holló Gábor
Published: December 2024

A hőszivattyúk közül egyre nagyobb arányban terjednek el a környezeti levegőt, mint hőforrást hasznosító típusok. A levegő hőforrás energia sűrűsége rendkívül alacsony, így nagy mennyiséget kell belőle átáramoltatni a kültéri egység hőcserélőjén. Éppen ezért a kültéri egység felállításakor körültekintően kell eljárni, hogy a közelben levő építmények, tereptárgyak ne zavarják meg a levegő áramlását. Amennyiben nem megfelelőek a telepítési körülmények, úgy hidraulikai rövidzár jöhet létre a beszívó- és kifúvó oldal között, ami a beszívott levegő hőmérsékletének csökkenését eredményezi. Ez a jelenség közvetlen hatással van a teljesítmény együtthatóra, vagyis az elérhető COP-re (Coefficience of Performance). Tekintve, hogy a jelenség szabad szemmel nem figyelhető meg, mérési eljárást dolgoztunk ki a jelenség kimutatására és mértékének vizsgálatára. Célunk olyan módszer kidolgozása, mely a lehető legegyszerűbb mérési eljárással, a lehető legkevesebb érzékelővel megvalósítható, de a gyakorlat számár megfelelő pontosságú eredményt ad. Ezzel lehetővé válik a korábban telepített hőszivattyúk kültéri egységeinek környezeti paraméter vizsgálata, különös tekintettel a hőmérsékleti viszonyokra.
Élelmiszer hulladékcsökkentést célzó, alma hűtve tárolási technológia vizsgálata
Authors: Farkas Anna , Ficzek Gitta , Veres Antal
Published: December 2024

Az alma megfelelő tárolása a minőség megőrzésének szempontjából kulcsfontosságú mind a fogyasztók, mind az élelmiszeripar hatékonyság szempontjából. A kutatás célja az almatárolás módszereinek, valamint lehetőségeinek feltárása elsősorban különböző tárolási körülmények között a vevők perspektívájából. A cél részletesen megvizsgálni a különböző tárolási körülmények hatását az alma fizikai és kémiai tulajdonságaira, valamint eltarthatóságára vonatkozóan, különös tekintettel a kereskedelmi és az otthoni tárolás közötti különbségekre.
A Golden Delicious almákat kereskedelmi forgalomból vásárolva, a fogyasztói magatartás szimulálva két hőmérsékleten (+5°C és +10°C) tároltuk tovább, a Magyar Agrár- és Élettudományi Egyetem Budai Campusának Gyümölcstermesztési tanszékén.
A fenntartható élelmiszertermelés és –fogyasztás egyre fontosabb szerepet játszik mindennapjainkban. A megfelelő tárolási módszerek feltárása hozzájárul az élelmiszerpazarlás csökkentéséhez és a fenntarthatóbb élelmiszerfogyasztás előmozdításához, amennyiben a fogyasztók képesek az almát megfelelően tárolni otthon, kevesebb gyümölcs megy veszendőbe.
Az élelmiszerpazarlás során keletkező élelmiszerhulladékokkal a lebomlás során keletkező üvegházhatású gázok kibocsátásának növekedésén túl a termelés és a szállítás során felhasznált erőforrások pazarlását is jelenti. A megfelelő otthoni tárolási módszerek feltárása elősegíti az alma minőségének megőrzését, és az energiafogyasztás csökkenését, valamint az élelmiszer-pazarlás mértékét is redukálja.
Green bonds as a tool for attracting investment in environmental projects
Authors: Hrubliak Oksana , Oleksyn Artur
Published: December 2024

Green bonds are one of the most popular sustainable investment instruments, and the green bond market is expected to flourish in the near future. Green bonds are becoming increasingly popular among environmentally responsible investors. The article reviews the literature related to the study of the green bond market, with the aim of highlighting the problems of using this financial instrument and providing information about the role of green bonds in developing the financial market of Ukraine and the economy as a whole. It is determined that the global green bond market is developing rapidly and covers not only developed countries but also the markets of developing countries. The author establishes that an important condition for the functioning of the green bond market is the issuer's obligation to fully disclose information on the use of the funds raised. Accordingly, transparent rules of the game in the green bond market attract more issuers and buyers of green bonds every year. Different types of green bonds are studied: use of proceeds bonds; use of proceeds revenue bonds or asset-backed bonds; project bonds; securitization bonds; covered bonds; unlabeled green bonds, their characteristics and features of their circulation. The article analyzes the trends in the development of the global green bond market and establishes that the volume of green bonds issued in the world has increased dramatically in recent years. The article examines the challenges that limit the possibility of issuing green bonds and mobilizing resources for the environmental sector: relatively broad criteria for green bonds, lack of formal guidelines for their issuance in emerging markets, liquidity and overconcentration risks for certain issuers, sectors or regions, credit or default risk, additional transaction costs, as issuers must track, monitor and report on the use of proceeds. The authors identify the main advantages of using green bonds for the development of the financial market of Ukraine: positive marketing history, investor diversification, tax incentives in the form of tax credits and exemptions, and financing of projects that provide environmental benefits.
Industry 4.0 and its impact on world countries in the context of achieving the 2030 sustainable development goals
Authors: Zelinska Dariia
Published: December 2024

The article examines the impact of Industry 4.0 concept on achieving the Sustainable Development Goals by 2030, particularly Goal № 9 «Industry, Innovation, and Infrastructure». The theoretical foundations of Industry 4.0 concept are analyzed, with systematization and generalization of definitions by leading scientists, based on which the author's interpretation of the term is proposed. Key components of Industry 4.0 are identified, including cyber-physical systems, Internet of Things, cloud computing, big data, artificial intelligence, robotics, and additive manufacturing, which contribute to achieving sustainable development goals. The relationship between the implementation of Industry 4.0 technologies and the realization of specific objectives of Goal №9 is investigated, including the development of quality infrastructure, modernization of industrial enterprises, stimulation of innovative activity, and ensuring equal access to digital technologies. A practical example of Industry 4.0 technology implementation is presented through the creation of a «smart» office model for IT enterprises in Ukraine using Cisco Packet Tracer tools. A conceptual model of such an office is developed, incorporating various Internet of Things devices to optimize energy consumption and improve operational efficiency. A detailed economic analysis of potential resources and cost savings from implementing the proposed technologies across Ukraine's entire IT sector is conducted. Calculations demonstrated the possibility of annual savings of approximately 50 million hryvnias and reduction of greenhouse gas emissions by 25,000 tons of CO2 equivalent when implementing smart office technologies in 2,500 IT companies nationwide. It is substantiated that Industry 4.0 also contributes to achieving other sustainable development goals, particularly in the areas of energy efficiency, environmental protection, and economic growth. Major challenges in ensuring equal access to Industry 4.0 technologies are identified, and solutions are proposed through expanded international support and the creation of a favorable political climate for domestic innovation development. Based on the conducted research, conclusions are formulated regarding the key role of Industry 4.0 in achieving sustainable development goals and the necessity of coordinated efforts at global and national levels to maximize its benefits.
Adaptation of material flow management to the requirements of globalized supply chains
Authors: Falovych Volodymyr , Besh Vitalii , Zelinskyi Serhii , Kapshii Yurii
Published: December 2024

The article examines the impact of globalization on the management of material flows of the modern business environment, in particular, in conditions of rapidly changing market conditions. The main challenges faced by enterprises are analyzed, among which changes in consumer demand, growing competition, as well as political and economic instability, which can negatively affect the effectiveness of resource management, are highlighted. The key adaptation strategies that allow companies to effectively respond to these challenges are characterized. The article proposes several methods, including inventory optimization using Just-In-Time (JIT) management systems, which help reduce costs and improve customer service. It also emphasizes the importance of automating logistics processes, which speed up order fulfillment and reduce the likelihood of errors. In particular, the need to develop flexible logistics schemes that allow planning alternative routes and suppliers was analyzed, which, in turn, reduces dependence on a single source. The importance of collaboration with partners is described, which is critical to creating efficient supply chains and reducing costs. In addition, special attention is paid to the role of environmental responsibility in the management of material flows, which is becoming more and more relevant in the modern world. The need to take into account environmental and social criteria in business processes, which can increase the reputation of enterprises and satisfy the demands of conscious consumers, is analyzed. It also includes implementing sustainable practices that not only meet ethical standards but also contribute to economic development. The conclusion of the article is that the adaptation of material flow management is a necessary condition for achieving sustainability and successful functioning of enterprises in a globalized environment. The proposed strategies allow companies not only to maintain their competitiveness, but also open new opportunities for development and growth, which is critical for successful operation in the conditions of the modern market.
Features of innovative entreprenuership development in the world in the context of global destabilization
Authors: Hrishchenko Danylo , Skrypnyk Nataliіa
Published: December 2024

The article explores the specifics of the development of innovative entrepreneurship worldwide in the context of global destabilization, particularly considering factors such as economic instability, geopolitical conflicts, natural disasters, and environmental issues. It analyzes how these phenomena are changing approaches to entrepreneurial activity, fostering the development of innovative strategies focused on adapting to new conditions. The impact of digital technologies, such as artificial intelligence, robotics, and automation, is examined, highlighting their role as a driving force behind innovative processes, providing flexibility and rapid response to changes. The article also emphasizes the role of environmental sustainability and green technologies, which are gaining strategic importance amid increasing attention to the issue of climate change. The implementation of new business models based on flexibility, risk diversification, and the search for global partnerships is considered key to the successful operation of businesses in crisis conditions. Special attention is given to examples of companies that successfully use innovative approaches to overcome the consequences of global challenges. The rapid development of e-commerce and digital platforms has provided companies with access to international markets. The ability to quickly adapt to new conditions and cultures has become a strategic advantage. Political and economic crises are driving businesses to diversify supply chains, including shifting to local production and reducing dependence on global suppliers. Under pressure from society and consumers, companies are increasingly integrating corporate social responsibility into their strategies, including support for social and environmental initiatives. These new realities create both challenges and opportunities for innovative entrepreneurship, encouraging constant adaptation and rethinking of strategies, and highlighting the relevance of the topic. The authors offer recommendations on ways to adapt innovative businesses to new realities, considering the need for developing digital infrastructure, active cooperation with international partners, and the implementation of ecological innovations.
Words that matter: The use of language with hate purposes
Authors: Cruschina Silvio , Gianollo Chiara
Published: December 2024

This chapter introduces the rationale behind the volume and the main topics discussed in the various chapters. It surveys the difficulties surrounding the definition of hate speech and singles out the main issues that are relevant for its linguistic investigation: besides the lexical elements (slurs, insults, derogatory epithets), more hidden pragmatic and grammatical strategies are also argued to characterise hate speech and aggressive language. In this respect, a rigorous evaluation of the contextual conditions by means of the tools provided by linguistics helps towards establishing a more precise identification of types of hate speech in conversational dynamics (explicit and implicit hate speech, intensity and degree of offensiveness, intentions, and effects).
Decoding implicit hate speech: Italian political discourse on social media during the COVID-19 pandemic
Authors: Retta Mattia
Published: December 2024

In this chapter, I examine the main linguistic and discursive features of anti-Chinese and anti-immigrant discourse in Italian political debate on social media. I combine a top-down approach, focusing on politicians, and a horizontal approach, which analyses the discourses produced by other social media users. The aims of this study are to identify the implicit levels of hate speech found in the corpus and to describe the intertextual and interdiscursive construction of discriminatory and stereotyping language. Implicitness is a key element of online political discourse, since a politician’s goal is to induce the audience to perceive the world in the way the politician wants them to. In the study, the pragmatic analysis shows that some kinds of connectives (contrastive, correlative, and temporal) and certain adverbial phrases emerge as effective structures to convey such implicit messages. The vilification of out-groups takes place mainly through dehumanising and naturalising metaphors, which are more effectively unveiled by the discourse analysis. This level of analysis also confirms previously identified metaphors and stereotypes used for othering migrants; however, some topoi seem to be more commonly attributed to specific categories, such as unreliability and brutality being used almost exclusively in relation to the Chinese.
Explaining the Willingness to Pay Higher Prices and Taxes to Combat Climate Change
Authors:   University of Wuerzburg, Doganoglu Toker , Grzybowski Lukasz ,   University of Warsaw, Faculty of Economic Sciences, University of Cape Town, School of Economics, Rachubik Joanna ,   University of Warsaw, Faculty of Economic Sciences
Published: December 2024

In this paper, we analyze the determinants of individual’s willingness to pay higher prices and
taxes and to reduce their standard of living to support environmental protection. Using data
from the 2020 International Social Survey Programme (ISSP), Environment IV module from 26
countries on about 29,000 individuals, we investigate the influence of socio-demographic factors,
consumer behavior, environmental beliefs, opinions, and attitudes. The findings reveal signif
icant variations in willingness to bear financial burdens for environmental protection across
different countries and socio-economic groups. Our analysis highlights the critical role of edu
cation, religion, political affiliation, and trust in institutions in shaping environmental attitudes
and behaviors. Moreover, after controlling for individual characteristics, significant interna
tional disparities persist, with countries like India showing exceptionally high willingness across
all measures, while many European countries, despite their progressive environmental policies,
show lower willingness for higher taxes due to possibly already high tax burdens. These find
ings underscore the importance of tailoring policy communications to different socio-economic
groups, emphasizing both the immediate and long-term benefits of environmental protection to
enhance acceptance among various demographic segments.
Molecular measurable residual disease by immunoglobulin gene rearrangements on circulating tumor DNA predicts outcome in diffuse large B-cell lymphoma
Authors: Soscia Roberta , Assanto Giovanni Manfredi , Starza Irene Della , Moia Riccardo , Talotta Donatella , Bellomarino Vittorio , Bellissimo Teresa , Antonacci Marco , Petrucci Luigi , Gaidano Gianluca , Guarini Anna , Martelli Maurizio , Di Rocco Alice , Foà Robin , Del Giudice Ilaria
Published: December 2024

In diffuse large B-cell lymphoma (DLBCL) treatment response relies on imaging. We investigated the potential value of molecular measurable residual disease (MRD) on circulating tumor DNA (ctDNA) to predict patient outcomes.
We retrospectively evaluated 73 patients. Analyses were conducted on 57 tumor biopsies, based on sample availability. At baseline, next-generation sequencing was used to detect clonal immunoglobulin (IG) gene rearrangements on tumor biopsies and ctDNA. MRD monitoring was applied by tracking the IG clones in ctDNA samples collected during treatment (interim) and at the end of treatment (EOT). MRD results were correlated with clinical data and radiologic disease assessment. Before treatment, clonal IG were found in 91.2% (52/57) of tumor biopsies and in 93.2% (68/73) of ctDNA samples. In paired samples, the same clonotype was found in 69.2% (36/52) of cases. At the interim analysis, ctDNA MRD was negative in 32/45 evaluable patients and positive in 13/45, correlating significantly with progression-free survival (PFS) (78.1% MRD- vs 30.8% MRD+; p
Clinical and laboratory risk factors for sickle cell retinopathy and maculopathy: a scoping review of the current evidence
Authors: Brandsen Rajani P. , Diederen Roselie M.H. , Kocabas Gizem , Nur Erfan , Malekzadeh Arjan , Schlingemann Reinier O. , Biemond Bart J.
Published: December 2024

Sickle cell retinopathy (SCR) is a complication of sickle cell disease (SCD) and can drastically impair visual acuity. Screening for SCR is therefore recommended, but evidence for optimal screening frequency on an individual level is lacking. This scoping review mapped the current evidence on risk factors for SCR and sickle cell maculopathy (SCM). A literature search (in Medline(Ovid), Embase(Ovid) and Scopus) resulted in 67 included articles, which covered demographic risk factors, genetic risk factors, systemic therapy, correlations with other forms of SCD-related organ damage and hematological risk factors. SCR risk factors include older age, male sex, HbSC genotype, hemolysis and HbF% 15%) patients to ensure comprehensive yet proportionate ophthalmic care. However, to elucidate the sense and nonsense of screening, future studies are needed on the role of interventions for SCR and the long-term consequences of SCM.
Comparison of Red Cell Indices between Hypertensive and Normotensive Individual in Rajshahi City
Authors: Rahman Nabila , Rahman Md Tahmid Ur , Gosh Emu , Tamanna Tanzina , Mahmud Yeasir , Ferdaus Jannatul
Published: December 2024

Background: Hypertension is a major public health problem worldwide. Hypertension is a risk factor for stroke, renal failure and cardiovascular disease and has an impact on hematological parameters. Hypertension with abnormal hematological parameters enhance end-organ damage. The aim of this study was to explore whether red cell indices parameters (MCV, MCH and MCHC) were associated with hypertension or not.
Materials and Methods: This cross-sectional comparative study was carried out in the Department of Physiology in collaboration with OPD Department of Medicine in Rajshahi Medical College from January 2019 to December 2019 among the hypertensive patients and normal adults in Rajshahi citywith ethical clearance from respective IERB. Samples were collected by purposive sampling technique. Pre-designed, validated, structured questionnaire was used to gather information from 60 hypertensive and 60 normotensive respondents residing in Rajshahi City. In both group, sex ratio was equal. Unpaired ‘t’ test was performed to compare the red cell indices between two groups. Data were analyzed by SPSS software, version-24. A p-value <0.05 was considered statistically significant.
Results: In hypertensive group, more than half (53.3%) of the respondents had systolic blood pressure between 140 to 159 mmHg and less than three-quarter (73.3%) had diastolic blood pressure between 100 to 120 mmHg. In the normotensive group, more than half (51.7%) of the respondents had systolic blood pressure between 110 to 119 mmHg and less than two-thirds (63.3%) had diastolic blood pressure between 70 to 79 mmHg. In both hypertensive and normotensive group, the majority of the respondent’s MCV level was 76-94 fL, MCH 27-32 Pg and MCHC 31-35 gm/dl. The hematological parameters including mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) were significantly increased in the hypertensive group compared to the normotensive group (p<0.001, p<0.001 and p=0.001 respectively).
Conclusion: By regular investigation of Red Cell Indices, it is possible to diagnose early hypertension, and appropriate measures might be taken to prevent hypertension related complications. Information from the study might be helpful for the concerned people to take appropriate measures for hypertensive patients and the basis for further in-depth study on this issue.
Eastern Med Coll J. July 2024; 9 (2): 62-67
Age, Gender and Side Distribution of Adhesive Capsulitis of Shoulder Among Diabetic Patients
Authors: Sharif Rayhan , Alam Shamina , Islam Md Ashikul , Alam Md Ehsanul , Raihan Md Galib
Published: December 2024

Background: Diabetes mellitus is a heterogeneous condition characterized by hyperglycaemia because of defects in insulin secretion, insulin resistance/action or combination of both of these factors. Many population-based studies established the association of shoulder pain and/or stiffness with diabetes mellitus. Adhesive capsulitis (AC) is the progressive painful restriction in range of movement and can reduce function and quality of life. 
Materials and Methods: This cross-sectional observational study was carried out in the outpatient department of Physical Medicine and Rehabilitation, Dhaka Medical College & Hospital (DMCH), Dhaka from July 2021 to June 2022with ethical clearance from respective IERB. A total of 122 diabetic patients with adhesive capsulitis attending the study place were selected by purposive sampling. The patient’s pain was recorded using the visual analogue scale (VAS). Movements of the affected shoulder joint were measured by using a goniometer. The validated Bangla version of Shoulder Pain and Disability Index (SPADI) was used to assess functional status. Variables were expressed as mean ± standard deviation (SD), frequency and percentage.
Results: In this cross-sectional observational study, a total of 122 diabetic patients with adhesive capsulitis were included in which, 60 patients (49.2%) were male and the rests 62 (50.8%) were female. The mean age of the patients was 51.9 ± 8.6 years. Among the patients, 47 (38.5%) were from the 45-54 years age group and 41 (33.6%) were from 55-64 years age group. In this study 74 patients (60.7%) had adhesive capsulitis on their right shoulder and the rests 48 (39.3%) had adhesive capsulitis on their left shoulder in this study. Conclusion: Adhesive capsulitis is one of the most common musculoskeletal disorders in patients with diabetes mellitus. It is recommended that diabetic patients should always be screened for the presence of rheumatic complications since early recognition lessens the chances of irreversible damage.
Eastern Med Coll J. July 2024; 9 (2): 73-76
A Comparative Study between Zinc Alone and Zinc with Racecadotril in Acute Watery Diarrhoea
Authors: Sufian Abu , Ahmed ATM Faruq , Hossain Abir , Bhuyan Mizanur Rahman , Sultana Sharmin , Chakrabarty Debashis , Hossen Mobarak , Amin Ruhul , Ghosh Uzzal Kumar
Published: December 2024

Background:Diarrhoea is one of the most common causes of morbidity and mortality in children under 5 years in the developing world. Racecadotril is a diesterified derivative of thiorphan. The objective of the study is to compare the effects of zinc alone and zinc with racecadotril in acute watery diarrhoea.
Materials and Methods: This prospective comparative study was carried out in the Department of Paediatrics, Abdul Malek Ukil Medical College &Jononeta Nurul Hoque Adhunik Hospital, Noakhali during July 2021 to December 2021with ethical clearance from respective IERB.Total 86 Children aged between 3-60 months requiring admission for severe acute gastroenteritis, as evidenced by a Modified Vesikari Score of >11 was included in this study. Patients were divided into two groups,Group-A: Zinc with racecadotril and Group-B: Zinc alone. All the information was recorded in the fixed protocol. Collected data were classified, edited, coded and entered into the computer for statistical analysis by using SPSS-23.
Results: Mean duration of diarrhoea was found 35.32±9.25 hrs in group-A and 31.57±11.38 hrs in group-B. The mean duration of hospital stay was 30.39±16.10 hrs in group-A and 41.53±18.38 hrs in group-B. Mean remission time was 49.7±23.22 hrs in group-A and 66.25±29.41 in group-B. The difference was statistically significant between the two groups. Skin rashes were found 4 (9.3%) in group-A and 6 (14.0%) in group-B. Angioedema was 3 (7.0%) and 1 (2.3%) in group-A and group-B respectively. Tonsilitis was 2 (4.7%) in group-B but no tonsilitis was found in group-A. Convulsion was 2 (4.7%) in group-A and 1(2.3%) in group-B.
Conclusion: When comparing the zinc plus racecadotril group to the zinc alone group, the mean frequency of diarrhoea, the mean length of hospital stays, and the mean remission time were all considerably lower. There was no discernible difference in the adverse occurrences between the two groups.
Eastern Med Coll J. July 2024; 9 (2): 51-55
Acne Vulgaris with Polycystic Ovarian Syndrome: A Case Report
Authors: Sikder Romana , Khan Morshed Uddin , Salam Shaikh Salman , Islam Sunjida
Published: December 2024

Acne vulgaris is a common chronic skin condition of pilosebaceous units that can be presented with non-inflammatory lesions, inflammatory lesions or mixture of both. This affects a large portion of teenagers and young adults (aged 15-40 years). About 85% of adolescents experience it. It is a polymorphic disorder (comedons, papules, pustules, nodules, cysts and sometimes scarring). Besides, Polycystic Ovarian Syndrome (PCOS) is a heterogeneous disorder of hormonal imbalance that occurs when ovaries produce unusual hormones during reproductive age. Clinically it is manifested by acne, oligomenorrhoea, subfertility and hirsutism. The presence of hyper-androgenism and metabolic problems may lead to the development of this condition. In this case study, a female aged 22 years presented with papules, pustules, some nodules in face and irregular menstrual cycle with no history of receiving any hormonal treatment. Clinical data including age, weight, height, BMI, menstrual history and androgenic sign (hirsutism, alopecia, acanthosis nigricans) were recorded with hormonal assay. A pelvic ultrasonogram was also done.
Eastern Med Coll J. July 2024; 9 (2): 125-128
Production Performance and Nutritional Quality of Black Soldier Fly Larvae Nurtured in Different Organic Waste
Authors: Ahmed Sonia Tabasum , Hassan Md Masudul , Islam Md Wahidul , Resmi Samira Islam , Hossain Md Mosharraf
Published: December 2024

Nutritionists are beginning to pay attention to black soldier fly (Hermetia illucens L.) larvae (BSFL) as an alternative to expensive soybean and fish meal in animal feed which is abundant in different nutrients. Additionally, organic wastes including leftover food, animal excreta, and agricultural wastes, can be used to efficiently raise and spread BSFL. This study was carried out to evaluate the yield, production performance and proximate composition of BSFL nurtured on different organic waste namely, broiler starter feed (BF); rice bran (RB); market-sourced vegetable wastes (VW); chicken manure (CM) and kitchen waste (KW). The BF fed group had the highest observed larval yields (16.2 kg in total; P<0.05). Raising BSFL on BF, VW and KW resulted in the greatest body weight (0.149, 0.147 and 0.150 g, respectively) and growth rate (0.012 g), whereas the KW fed group had the longest body length (P<0.05). The fed groups that received CM and BF had the highest and lowest mortality rates, respectively (P<0.05). All fed groups except RB had improved feed conversion ratios, while VW and KW fed groups had higher protein conversion ratios (2.626 and 2.852, respectively; P<0.05). All the group had better substrate reduction rate compared to CM fed group (P<0.05). The dry matter and ash contents of BSFL reared on BF, VW and KW were higher than the RB and CM group (P<0.05). The KW supplemented BSFL had the highest ether extract level, whereas the BF fed group had the highest protein content (43.58%, P<0.05). In conclusion, BSFL can be successfully reared on kitchen and vegetable scraps. It is anticipated that the cost of black soldier fly farming and animal production will decrease since these organic waste shown favorable effects on BSFL growth performance and nutritional quality comparable to broiler feed in the current study.
J. of Sci. and Tech. Res. 6(1): 139-148, 2024
Molecular Diagnosis of Major Emerging Tomato Infecting Viruses and Their Vector Population Dynamics
Authors: Akhter Md Shamim , Rahman Mohammad Siddiqur , Islam Rummana
Published: December 2024

Tomato is an important vegetable crop in Bangladesh, growing year-round in both kitchen gardens and large-scale commercial farming. Many diseases affect the solanaceous vegetable crop, particularly viral diseases. Using modern molecular methods and vector population dynamics, we attempted to detect major emerging viral infections of tomato. A survey was conducted in different locations of Bangladesh, namely Rajshahi, Jamalpur, Jessore, and Joydebpur to assess viral infections in tomato and associated insect vectors. Various forms of viral disease symptoms were observed to infect tomato in the examined area, including mosaic, yellowing, mottling, leaf curling, and bud necrosis, with a incidence ranging from 20 to 100%. Among the different viral diseases, leaf curl was the most common, accounting for 100% of the cases. Field resistance to viral infections was investigated among the BARI released tomato varieties, and all of the tomato types tested were infected with the leaf curl virus. In addition, the examined area had a moderate to high prevalence of chlorosis and purple vein disease. The viruses identified by DACELISA, PCR, and RT-PCR were tomato leaf curl virus (ToLCV) and groundnut bud necrosis virus (GBNV).
J. of Sci. and Tech. Res. 6(1): 161-167, 2024