bluuebunny/crossref_metadata_2025 huggingface dataset:
Myocardial electroporation — an alternative to thermal methods of atrial fibrillation treatment
Authors: Archakov E. A. , Batalov R. E. , Khlynin M. S. , Smorgon A. V. , Popov S. V.
Published: July 2023

Atrial fibrillation is one of the most common cardiac arrhythmias. By all estimates, the number of patients with this arrhythmia will only increase. Currently, the main and most used methods for the treatment of atrial fibrillation are radiofrequency and cryo-balloon ablation. However, the accumulated experience of their use has revealed a number of shortcomings — the lack of long-term pulmonary vein isolation, as well as life-threatening procedure complications. Relatively recent foreign studies showed data on the use of an alternative method of influencing arrhythmogenic foci. The method is based on the use of non-thermal pulsed field ablation, which leads to the appearance of pores in cardiomyocytes and their necrosis, which causes a more stable electrical left atrial pulmonary vein isolation. The margins of the lesions in this exposure are usually very sharp with a narrow transition from normal tissue to tissue with the complete necrosis, while not damaging neighboring structures such as blood vessels, nerves and esophagus. At present, information published in the literature on the use of pulsed field ablation in various fields of medicine, including oncology and cardiology, is clearly not enough. The implementation of this method for the interventional treatment of cardiac arrhythmias is considered a promising direction and is the subject of research by many leading scientific groups around the world. The purpose of this review is to structure the most significant information on the use of pulsed field ablation, presented in the literature, to analyze its possibilities, effectiveness, and disadvantages.
Heart failure with improved ejection fraction in patients with tachycardia-induced cardiomyopathy: a case report
Authors: Pravkina E. A. , Kochnova E. N. , Pereverzeva K. G. , Yakushin S. S.
Published: July 2023

Heart failure and arrhythmias are pathogenetically closely interconnected and they are mutually aggravating each other. At the same time, tachycardia-induced cardiomyopathy is particularly a reversible disease with proper treatment. This article presents a case report of an elderly patient with hypertension and atrial fibrillation, which are associated to an advanced heart failure and complicating the management of a decreasing kidneys filtration capacity, hematuria and brain stroke. In this case report, tachycardia-induced cardiomyopathy is caused by persistent atrial fibrillation. A complex approach to diagnosis and evidence-based treatment (in particular cardioversion and radiofrequency ablation) made it possible to restore sinus rhythm and compensate heart failure. Dynamics of the clinical state of the patient, laboratory indicators, echocardiographic characteristics allowed us to retrospectively verify atrial fibrillation-mediated cardiomyopathy as the main cause of heart failure progression, and classify this clinical case as heart failure with improved ejection fraction.
Recurrent bleeding during standard anticoagulant therapy in comorbid patients with atrial fibrillation: a clinical case report
Authors: Kudriavtseva A. A. , Kolpachkova E. V. , Gebekova Z. A. , Sadulaeva T. A. , Sokolova A. A. , Napalkov D. A.
Published: July 2023

The question of the safety of direct oral anticoagulants (DOACs), despite their high efficacy in the prevention of thrombotic events in atrial fibrillation (AF), remains relevant due to the risk of developing hemorrhagic events while taking standard doses, which requires a thorough personalized approach. The article presents a clinical case of the development of spontaneous hematomas on the skin of the upper and lower extremities and hemarthrosis of the knee joint while taking 20 mg of rivaroxaban in a 72-year-old patient with AF without impaired renal and hepatic function. Due to the increase in the residual plasma concentration of rivaroxaban, a pharmacogenetic study and the Thrombodynamics (TD) test were performed. A pharmacogenetic study did not reveal significant gene polymorphisms associated with the metabolism of rivaroxaban. However, TD allowed us to confirm the presence of significant hypocoagulation at the peak of the residual blood concentration of the drug in the blood, which could cause recurrent hemorrhagic events in the patient. In addition, the patient is taking amiodarone at a dosage of 200 mg per day, which does not allow us to rule out drug-drug interaction, despite the inconsistency of the literature data.
Ventricular tachycardia and myocardial infarction during antiarrhythmic therapy: a case report
Authors: Gurbanova A. A. , Pereverzeva K. G. , Yakushin S. S. , Budanova I. V.
Published: July 2023

The article analyzes the case of the development of ventricular tachycardia and type 2 myocardial infarction (MI) in an 80-year-old patient with a history of coronary artery disease, MI and chronic heart failure. In 2020, the patient was diagnosed with ventricular extrasystole and started antiarrhythmic therapy with diethylamino propionylethoxycarbonylaminophenothiazine 150 mg per day and sotalol 160 mg per day. In 2022, the patient had an episode of clinical death due to ventricular tachycardia with successful resuscitation. A diagnosis of non-ST-elevation acute coronary syndrome was made, coronary angiography was performed, which did not reveal significant coronary stenosis. Upon further examination, the dynamics of biomarkers of myocardial necrosis confirmed the diagnosis of acute MI. In the analyzed case, the development of ventricular tachycardia and MI is most likely associated with the intake of diethylaminopropionylethoxycarbonylaminophenothiazine in combination with sotalol, prescribed in the presence of contraindications to their use.
A Comparison of Match Rates to Orthopaedic Surgery Residency Programs Between First-Time Versus Repeat Applicants
Authors: Dhillon Jaydeep , Kraeutler Matthew J. , LaPorte Dawn M. , Eberson Craig P. , Mulcahey Mary K.
Published: July 2023

Introduction:

Orthopaedic surgery has become one of the most competitive specialties to match into among medical students applying to residency. The purpose of this study was to compare match rates to orthopaedic surgery residency programs among first-time vs. repeat applicants.

Methods:

Data were obtained from the National Resident Matching Program from 2018 to 2022. For each year, the total number of applicants to orthopaedic surgery residency programs was obtained, as well as the number of applicants who successfully matched into orthopaedics. The match rate was compared between first-time vs repeat applicants. A subanalysis was performed on allopathic graduates (MDs) and osteopathic graduates (DOs)/international medical graduates (IMGs). In addition, the match rate for first-time applicants and reapplicants was compared between MD and DO/IMG applicants.

Results:

Overall, there was a significantly higher match rate among first-time applicants (89.8%) vs. repeat applicants (22.5%, p < 0.0001). When substratified by MD and DO/IMG applicants, first-time applicants still matched at a significantly higher rate than reapplicants within each group (p < 0.0001 for each). Among first-time applicants, MDs (93.1%) matched at a significantly higher rate than DOs/IMGs (68.6%, p < 0.0001). Among reapplicants, DOs/IMGs (25.3%) matched at a significantly higher rate than MDs (20.1%, p < 0.01).

Conclusion:

First-time applicants to orthopaedic surgery residency programs have a significantly higher rate of matching compared with reapplicants, irrespective of degree. In recent years, first-time MD applicants have matched at a significantly higher rate than first-time DO/IMG applicants.
VALEČOVŠTÍ SKALÁCI POHLEDEM HISTORICKÉ DEMOGRAFIE A ETNOHISTORIE
Authors: Křížová Lenka
Published: July 2023

The article approximates the demographic behavior of the inhabitants of the rock dwellings near Valečov Castle in the former political and judicial district of Mnichovo Hradiště/Münchengrätz. It also describes their history. A specific community of the poorest villagers was evicted in 1892. The text is based on the method of family reconstruction and other archival research.
El uso de la Inteligencia Artificial en el proceso de diseño del habla y el lenguaje de un personaje de videojuegos
Authors: Alonso Urbano David , Cantos Leal Rubén
Published: July 2023

Este estudio parte de los resultados obtenidos en la investigación previa de Rubén Buren (2019) donde el autor ofrece instrumentos de mecanización para la construcción de personajes audiovisuales en un videojuego, a través de ciertas señales que lo deben componer como ser autónomo y diferenciado. Como hecho novedoso, coloca el foco de atención en la particularización e individualización que otorga a un personaje, o grupo de personajes, la confección de frases, palabras, un determinado uso del habla o un lenguaje ya sea fonoarticulado, sonoro o escrito. En este artículo se describe cómo esta mecanización en la construcción de personajes de videojuegos se puede combinar con ChatGPT, una aplicación de inteligencia artificial (IA) basada en el software GPT-3.5 de la empresa OpenAI, que es capaz de generar textos y resolver gran variedad de tareas, y que ha despuntado durante el año 2022. Entendiendo que ChatGPT utiliza un modelo probabilístico a la hora de generar textos, y que los algoritmos que configuran esta IA se basan en el aprendizaje por refuerzo, se pretende investigar hasta qué punto esta herramienta está entrenada y se puede entrenar para ser un asistente en el proceso de diseño de personajes de videojuegos.
diseño de eventos experienciales corporativos: el caso del Evento World Corporate Golf Challenge
Authors: Galmés Cerezo María , RODRÍGUEZ CARMEN CRISTÓFOL , Estrada Fernández-Hontoria Luis
Published: July 2023

Los eventos corporativos son una excelente herramienta de relaciones públicas tanto a nivel interno como externo y ayudan a crear experiencias que vinculan a sus públicos con la organización en cuestión. En esta investigación analizaremos el caso del Torneo World Corporate Golf Challenge, la mayor competición de golf amateur del mundo, desde la perspectiva de los eventos corporativos experienciales. Los eventos deportivos de golf adquirieron especial protagonismo en los años anteriores a la pandemia por sus posibilidades de ofrecer experiencias relacionales entre los públicos de las empresas (tanto entre clientes como empleados). Los torneos de golf han mostrado ser una herramienta de relaciones públicas apropiada para promover experiencias significativas que generan cercanía y confianza entre las empresas participantes y sus grupos de interés. Se ha estudiado el Caso World Corporate Golf Challenge desde la perspectiva del diseño de la experiencia corporativa en sus dimensiones sensorial, emocional, intelectual, relacional y de acción.
compromiso cívico en tiempos de crisis
Authors: Conejero Paz Enrique
Published: July 2023

En esta reseña se exponen la ideas principales de la obra de la polítóloga y jurista Victoria Rodríguez Blanco publicado en 2022 por la editorial Aula Magna, una obra que es una recoplilación de columnas de opinión publicadas en diversos medios de comunicación durante los últimos años. La temática es variada y heterogénea; la corrupción, los partidos políticos, la educación, la independencia judicial o la gestión pública siguen siendo preocupaciones ciudadanas de total actualidad. La idea fuerza que emerge en la reseña es el compromiso cívico de la autora y el papel del científico social al respecto. La autora es una científica social que se implica en la transformación de la realidad en la que vive, es coherente y la mayoría de los artículos sugieren reformas que a su juicio mejorarían la calidad democrática del sistema político en España.
Therapeutic Effect of San-Zi-Yang-Qin Decoction on Obese Pre-hypertension: A Non-targeted Combined with Pseudo-targeted Metabolomics
Authors: li shumin , Dong Meiyue , Jiang Haiqiang , Li Yunlun , Qi Dongmei
Published: July 2023

Background Evaluation of the intervention effect of SZD on high-fat and high-salt induced obese Pre-hypertension rats from the perspective of metabolomics, and to explore the metabolic mechanism of SZD for the treatment of obese Pre-hypertension Methods In this study, the efficacy of SZD was evaluated by blood pressure, body weight, Lee’s index, and biochemical indexes, and the mechanism of SZD in the treatment of obese prehypertensive rats induced by high-salt the high-fat mode was explored through non-targeted metabolomics combined with pseudo-targeted metabolomics. Results SZD intervention reduced systolic blood pressure(SBP), diastolic blood pressure(DBP), mean arterial pressure, and reduced body weight and Lee's index in rats, which had some improvement effect on obesity. It also reduced triglyceride(TG), total cholesterol(TC), Low-density lipoprotein cholesterol(LDL),Hypersensitivity C-reactive protein(Hs-CRP) levels in rats, but had no significant elevation effect on High-density lipoprotein cholesterol(HDL). Analysis of 35 biomarkers in the model and 31 biomarkers in the SZD intervention by non-targeted metabolomics revealed that SZD interfered with 7 of these metabolites (estradiol, sphingosine, TXB2, LysoPC (20:2), LysoPE (22:0), LysoPC (22:5), LysoPC (20:0)). The further content analysis of 7 metabolites by pseudo-targeted metabolomics revealed an increase in estradiol and sphingomyelin,and a decrease in LysoPC (20:2), LysoPE (22:0), LysoPC (22:5), and LysoPC (20:0) after SZD intervention, which involved in glycerophospholipid metabolism, sphingolipid metabolism, linoleic acid metabolism, and arachidic acid metabolism. Conclusions SZD was finally found to improve obesity and decreased blood pressure.The preliminary investigation of the efficacy mechanism of SZD intervention in obese Pre-hypertension enriched the pharmacological effects of SZD.
SALL3 mediates the loss of neuroectodermal differentiation potential in human embryonic stem cells with chromosome 18q loss
Authors: Spits Claudia , Lei Yingnan , Delbany Diana Al , Krivec Nuša , Regin Marius , de Deckersberg Edouard Couvreu , Janssens Charlotte , Ghosh Manjusha , Sermon Karen
Published: July 2023

Human pluripotent stem cell (hPSC) cultures are prone to genetic drift, as cells that have acquired specific genetic abnormalities experience a selective advantage in vitro. These abnormalities are highly recurrent in hPSC lines worldwide, but currently their functional consequences in differentiating cells are scarcely described. An accurate assessment of the risk associated with these genetic variants in both research and clinical settings is therefore lacking. In this work, we established that one of these recurrent abnormalities, the loss of chromosome 18q, impairs neuroectoderm commitment and affects the cardiac progenitor differentiation of hESCs. We show that downregulation of SALL3, a gene located in the common 18q loss region, is responsible for failed neuroectodermal differentiation. Knockdown of SALL3in control lines impaired differentiation in a manner similar to the loss of 18q, while transgenic overexpression of SALL3 in hESCs with 18q loss rescued the differentiation capacity of the cells. Finally, we show by gene expression analysis that loss of 18q and downregulation of SALL3 leads to changes in the expression of genes involved in pathways regulating pluripotency and differentiation, including the WNT, NOTCH, JAK-STAT, TGF-beta and NF-kB pathways, suggesting that these cells are in an altered state of pluripotency.
Pedicled ALT-flap for soft tissue reconstruction in the trochanteric area
Authors: Vater Adrian , Moncher Johanna , Schmidt Karsten , Jordan Martin , Jakubietz Michael , Meffert Rainer , Jakubietz Rafael
Published: July 2023

Purpose: Coverage of soft tissue defects following surgery at the trochanteric area is challenging. Revision surgery in case of compromised wound healing may lead to soft tissue defects requiring reconstruction with pedicled or free flaps. Previous access to the hip joint may jeopardize neurovascular structures relevant to the flap. In this study, we evaluated if pedicled anterior lateral thigh (ALT) flap is a valueable option for soft tissue reconstruction in this situation.
Methods: In this retrospective study, five patients were included. Defect etiology was tumor resection in one case, screw osreosynthesis in another case and total hip arthroplasty in three cases. All patients underwent reconstruction by proximal pedicled anterior lateral thigh (ALT) flap.
Results: Pedicled ALT flap was a safe procedure in all cases. One patient showed delayed wound healing with need for additional surgery. No further complications were observed.
Conclusion: Pedicled ALT flap transfer represents a reliable option for soft tissue coverage in the trochanteric area after primary surgery such as hip arthroplasty, osteosynthesis or tumor resection.
Long-term effect of municipal solid waste compost on the recovery of a potentially toxic elements (PTEs)-contaminated soil: PTEs mobility, distribution and bioaccessibility
Authors: Caporale Antonio Giandonato , Porfido Carlo , Roggero Pier Paolo , Palma Anna Di , Adamo Paola , Pinna Maria Vittoria , Garau Giovanni , Spagnuolo Matteo , Castaldi Paola , Diquattro Stefania
Published: July 2023

Compost from municipal solid waste (MSWC) can represent a resource for the environmental management of soils contaminated with potentially toxic elements (PTEs), since it can reduce their mobility and improve soil fertility. However, the long-term impact of compost on soil recovery has been poorly investigated. To this end, the influence of a MSWC added at different rates (i.e. 1.5, 3.0 and 4.5% w/w) to a multi PTEs-contaminated (e.g. Sb 412 mg kg-1, Pb 2664 mg kg-1, and Zn 7510 mg kg-1) sub-acidic soil (pH 6.4) was evaluated after 6 years since its addition. The MSWC significantly enhanced soil fertility parameters (i.e. total organic carbon, Olsen-P and total N) and reduced the PTE labile fractions. The distribution maps of PTEs detected through μXRF analysis revealed the presence of Zn and Pb carbonates in the amended soils, or the formation of complexes between these PTEs and the functional groups of MSWC. A higher oral, inhalation and dermal bioaccessibility of each PTE was detected in the soil fine-grained fractions (<2 and 2-10 µm) than in coarse particles (10-20 and 20-50 µm). The MSWC amendment generally did not modify the PTEs bioaccessibility; while the relative bioaccessibility of cationic PTEs was greater than that of anionic ones (e.g. Cd> Zn> Pb> Sb> As). Pb and Sb showed the highest Hazard Quotients (e.g. 2.2 and 10 for Sb and Pb, respectively, in children). Overall, the results indicated that the MSWC used can be an effective option for the recovery of PTEs-contaminated soils, even in the long term.
Is Dispatcher-Assisted Cardiopulmonary Resuscitation Affected By a Bystander's Emotional Stress State in Out-of-hospital Cardiac Arrest?
Authors: Tuffley Rebecca Hvidt , Folke Fredrik , Ersbøll Annette Kjær , Blomberg Stig Nikolaj Fasmer , Linderoth Gitte
Published: July 2023

Aim The study aimed to investigate whether a bystander’s emotional stress state affects dispatcher-assisted cardiopulmonary resuscitation (DA-CPR) in out-of-hospital cardiac arrest (OHCA). The primary outcome was initiation of chest compressions (Yes/No). Secondarily we analysed time until chest compressions were initiated and assessed how the dispatcher instructed CPR.
Method The study was a retrospective, observational study of OHCA emergency calls from the Capital Region of Denmark. Recorded calls were evaluated by five observers using a pre-defined code catalogue regarding the variables wished investigated.
Results Included were 655 OHCA emergency calls, of which 211 callers were defined as emotionally stressed. When cardiac arrest was recognized, chest compressions were initiated in, respectively, 76.8% of cases with an emotionally stressed caller and 73.9% in cases with a not emotionally stressed caller (2.18 (0.80-7.64)). Cases with an emotionally stressed caller had a longer time until chest compressions were initiated compared to cases with a not emotionally stressed caller, however non-significant (164 sec. vs 146 sec.; P=0.145). The dispatchers were significantly more likely to be encouraging and motivating, and to instruct on speed and depth of chest compressions in cases with an emotionally stressed caller compared to cases with a not emotionally stressed caller (1.64 (1.07-2.56); 1.78 (1.13-2.88)). Barriers to CPR were significantly more often reported in cases with an emotional stressed caller compared to cases with a not emotional stressed caller (1.83 (1.32-2.56).
Conclusion There was no significant difference in initiation of chest compressions or in time until initiation of chest compressions in the two groups. However, the dispatchers were overall more encouraging and motivating, and likely to instruct on speed and depth of chest compressions when the caller was emotionally stressed. Furthermore, barriers to CPR were more often reported in cases with an emotional stressed caller compared to cases with a not emotional stressed caller.
TRIAL REGISTRATION
We applied for ethical approval from The Danish National Committee on Health Research Ethics, but formal approval was waived. We received permission for storage of data and to use these for research of OHCAs in the Capital Region of Denmark by Danish Data Protection Agency (P-2021-670) and Danish Health Authorities (R-2005114). The study is registered at ClinicalTrials (NTC05113706).
Real-time comparison of terlipressin vs. octreotide as an adjuvant treatment in the management of variceal bleeding
Authors: Rehman Hareem , Rehman Syed Tabish , Zulfiqar Shahzana , Awan Safia , Abid Shahab
Published: July 2023

Variceal bleeding is a major complication and the leading cause of death in patients with cirrhosis and portal hypertension. This study aims to compare the efficacy and safety of Terlipressin vs octreotide as an adjuvant to endoscopic management of patients with esophageal variceal bleeding in a real-time scenario. We reviewed the medical records of patients with esophageal variceal bleeding from January 2005 to December 2020 at our tertiary care Aga Khan University Hospital. Mortality was assessed after 6 weeks. A total of 842 patients with variceal bleed were evaluated. 624 patients (74.1%) and 218 patients (25.9%) received Terlipressin and Octreotide respectively. On multiple regression analysis, cardiac events during hospital stay (OR: 11.22), presence of Porto-systemic encephalopathy (OR: 3.79), and elevated bilirubin levels at the time of presentation were found to be independent risk factors for increased six weeks mortality. Moreover, cardiac events during hospital stay (OR: 3.26), Porto-systemic encephalopathy at presentation (OR: 3.06), and octreotide administration (OR: 1.80) were identified as independent risk factors for increased length of hospital stay. Terlipressin and Octreotide have similar outcomes in terms of control of bleeding, hospital stay, mortality, and side effects when used as adjuvant therapy for the management of variceal bleeding.
Relationship between early life asthma and chronic airway disease in adult life – in search for disease trajectories over the life span - The RELATE study based on the Kongsberg cohort
Authors: Savran Osman , Bønnelykke Klaus , Ulrik Charlotte Suppli
Published: July 2023

Background: Chronic airway disease in adults may have its origin in early life. The purpose of this study is to investigate the long-term prognosis of severe childhood asthma in search for an association between asthma in early life and obstructive lung disease in adulthood.
Methods: This study is based on the Kongsberg cohort, which includes approximately 5000 children with severe asthma with a 4-month stay at the asthma care facility in Kongsberg, Norway during the years 1950 to 1979. An on average 60-year follow-up examination will be performed including questionnaires, blood samples, and tests of lung function and bronchial responsiveness. Blood samples will be stored in a biobank. In addition, we will conduct further analyses of the cohort based on nationwide register data, including socio-economic parameters and mortality.
Discussion: Chronic airway disease is associated with substantial burden for both the individual patient and society. Our knowledge of early life origins of chronic airway disease later in life has been increasing in recent decades but is still limited. By exploring early life risk factors for chronic airway disease in adulthood, we may gain insights paving the way for future reduction in the burden of chronic airway diseases.
Prediction Model of mental health of Middle-aged and older adults in China
Authors: Li Yong , Kong Lingrui
Published: July 2023

The phenomenon of aging has emerged as a prominent concern within the context of China's economic and social progress. The middle-aged and elderly population suffers the dual burden of psychological and physiological challenges due to the decline in their physiological functions. However, the intricate nature of mental health diagnostic analysis poses difficulties in early predicting and intervening in mental health issues affecting middle-aged and elderly individuals. We attempt to establish a benchmark for evaluating the mental health of middle-aged and older adults based on psychological theories. Additionally, we propose a hypergraph-based mental health prediction model, termed MH-HGNN, specifically designed for this demographic. MH-HGNN incorporates a hypergraph structure to capture and process complex high-order correlation relationships by representing middle-aged and elderly individuals as nodes. By applying Laplace polynomial spectral convolution representation learning on these relationships, the model forecasts the mental health status of this population segment. Empirical findings indicate that MH-HGNN achieves an 82.7% accuracy rate in predicting mental health outcomes, surpassing the performance of prevalent deep learning baseline techniques like GNN, GAT, and GraphSAGE. Notably, the MH-HGNN model exhibits an improvement of up to 9.17% in accuracy compared to the baseline model.
Long term efficacy of three chitin synthesis inhibitors and oxymatrine as cowpea seed protectants against Callosobruchus maculatus and Callosobruchus chinensis
Authors: Gad Hassan A. , Al-Ayat Adel A. , Mohamed Hamdy A. , Abdelgaleil Samir A.M.
Published: July 2023

The residual efficacy of three chitin synthesis inhibitors (CSIs) (chlorfluazuron, hexaflumuron and lufenuron) and oxymatrine at an application rate of 5.0 mg/kg was evaluated against Callosobruchus maculatus and Callosobruchus chinensis monthly for 5 consecutive months (6 bioassays). In each bioassay, the mortality of two insect adults was counted after 7 days, progeny reduction and cowpea weight loss percentages were recorded after 45 days. Our results revealed that CSIs caused high level of adult mortality of both insects and oxymatrine caused a complete adult mortality (100%) for five months storage. The tested CSIs produced a significant progeny reduction of C. maculatus and C. chinensis but did not achieve a complete reduction of F1 progeny during all storage periods. A complete progeny suppression of two insects and full cowpea seed protection were observed in all oxymatrine treatments during the entire storage periods. A remarkable protection of cowpea seeds was also achieved in the treatments with CSIs particularly chlorfluazuron during the first 3 months. These findings indicate CSIs and oxymatrine could be implemented in IPM of these insects.
Does Mandibular Osteotomy Affect the Infraorbital Nerve? A Prospective Study
Authors: Ak Kıvanç Berke , Özel Abdullah , Süzen Muazzez , Uçkan Sina
Published: July 2023

Objectives
The aim of this study was to evaluate the sensory function of the infraorbital nerve after orthognathic surgery (OS) .
Materials and methods
Patients who underwent Le Fort I osteotomy with or without BSSO for dentofacial deformity treatment were studied. Two groups were created according to whether BSSO was performed. Class A tests were performed to determine the degree of peripheral nerve damage. The Class B test was performed if decreased sensation was detected in at least one of these tests. A Class C test was performed if abnormal sensation was detected.
Results
Twenty-eight patients (n = 56) who underwent OS were included in this prospective study. Of the patients, 57.1% were female, 42.9% were male, and the mean age was 24.6 (± 3.8). Seven patients were in group 1 (n = 14), and 21 patients were in group 2 (n = 42). In both groups, there were statistically significant differences between T1 and T2 (p < 0.001), and the mean NSD score at T2 was higher than that at T1. The mean NSD score in the single jaw group was higher than that in the double jaw group at all time points.
Conclusions
Bimaxillary surgeries had a negative effect on the somatosensory changes that developed in the early period. The upper lip’s somatosensorial recovery was faster than IOR and single jaw recovery was faster than double jaw.
Clinical relevance:
Maxillofacial surgeons performing orthognathic surgery should be aware that in double jaw operations, changes in the somatosensory function of the ION are more severe.
An Empirical Study of the Influences of Gustiness on Vertical Mixing in Air-sea Boundary Layer
Authors: lyu Meng , Potter Henry , Ortiz-Suslow David , Wang Qing , Wang Xiaoqi
Published: July 2023

The exchange of momentum across the air-sea interface is a key driver of the earth system and its accurate parameterization is essential for precise weather and climate forecasting. However, our understanding of gustiness as an independent factor that can contribute to the momentum flux is still limited. Using data collected from the R/P FLIP, as part of the Couple Air-sea Processes and Electromagnetic Ducting Research (CASPER) experiment, we explored the mechanisms by which gustiness contributes to the total interfacial momentum flux. We investigate how gustiness affects both the temporal and spatial (vertical) variance of turbulence in the atmospheric surface layer. We identified that high gustiness was associated with strong anisotropic turbulence at each measurement height. This was found to increase vertical wind fluctuations and inject additional momentum across the air-sea interface at lower wind speeds. Increased gustiness was founded associated with the breakdown of the constant flux layer, which is generally assumed valid over the ocean. The study of gustiness presented in this paper has implications for both momentum flux parameterization and the use of similarity theory to model the flux-gradient relationship in the gusty atmospheric surface layer, thereby influencing the forecasting of climate and extreme weather events.
Risk Assessment of multiple mycotoxins and trace metals through mother milk consumption to neonates in India
Authors: Maurya Kamlesh , Mandal Payal , Saifi Ishrat J. , Shukla Aditya , Naseem Mariya , Dixit Sumita , Srivas Pankaj K. , Yadav Akhilesh K. , Verma Sanjeev K. , Ansari Kausar M
Published: July 2023

Mother’s milk is a unique biological fluid providing essential nutrients for the proper growth and development of neonates. Surveillance reports indicated continuous exposure to various contaminants to humans. These xenobiotics tend to mobilize into multiple body fluids, including mother’s milk, thus creating a higher risk to mother’s milk-fed neonates. This study aimed to determine the extent of mycotoxins, trace and toxic metals contamination in mother’s milk, and health risk assessment of mother’s milk-dependent neonates. In this study, mycotoxins and metals were analyzed in the milk of 100 Indian nursing mothers. Aflatoxin M1(AFM1) was detected by ELISA, whereas Ochratoxin (OTA), α-Zearalenol(α-ZEL), β-Zearalenol (β-ZEL) and Zearalenone (ZEN) were analyzed by LC-HRMS. Metals were analyzed using ICP-MS. In the 100 analyzed samples, the detection of AFM1, OTA, ZEN, α-ZEL, and β-ZEL were 73%, 96%, 30%, 15%, and 7%, respectively. In breastfed infants, the estimated daily intake (EDI) of AFM1, OTA, and ZEN were 0.005, 0 0.047, and 0.024 µg/L BW/day. Similarly, metals analysis showed the presence of Cr, Mn, As, Cd, and Pb were 26%, 49%, 42%, 34%, and 12%, respectively. The HQ > 1 in arsenic indicates possible health risks for the infants. A significant correlation was found among all metals except As. α-ZEL, β-ZEL, and ZEN were significant among themselves. Altogether, results suggest a potential risk of mycotoxins and trace toxic metals for neonates via mother’s milk which requires immediate attention and must be regulated promptly.
Outpatient orthognathic surgery: a prospective study of predictive factors for the length of hospital stays.
Authors: Prevost Alice , Lauwers Frédéric , Varazzani Andréa , Poulet Vinciane , Mure Marion , Lopez Raphael , Cavallier Zoé
Published: July 2023

Objectives
Transitioning from non-outpatient orthognathic surgery to outpatient surgery is a new challenge, and it is essential to target the eligible population as precisely as possible. Several authors describe series of outpatient orthognathic surgery but do not include the reasons for their success or failure.
The main aim of this study was to identify the factors significantly associated with "successful" outpatient orthognathic treatment.
The secondary objective was to determine the factors significantly associated with prolonged hospital stays (≥ 2 nights).
Materials & Methods:
A prospective cohort study including patients undergoing orthognathic surgery was conducted over a period of 1 year. We recorded the prognostic factors that contributed to successful outpatient treatment and prolonged hospital stays. These factors were evaluated by bivariate and multivariate analysis.
Results:
102 patients were included and the success rate of treatment was 65%. The variables that were isolated by multivariate analysis were: patients over the age of 22, procedures ending before 1 pm, brief operations, the absence of both postoperative vomiting and the administration of morphine.
Conclusion:
Patient selection, organisation of outpatient facilities and anaesthetic protocols contribute to the development of outpatient orthognathic surgery. These initial considerations provide a framework for our practice, but the considerations that predict the failure of outpatient surgery will need to be clarified.
Clinical Relevance:
Orthognathic surgery can be performed on outpatient basis in selected cases. Age, the operative time, procedure end time, postoperative vomiting and the administration of morphine are associated with the success of outpatient care.
Evaluating resistance of potato cultivars to powdery scab and transcriptome analysis under the stress of Spongospora subterranea
Authors: Liu Xia , Yang Yanli , Huang Xun
Published: July 2023

Spongospora subterranea f. sp. subterranean causes powdery scab of potato and can result in significant losses to the production. In searching strategies of disease control, 22 potato cultivars were collected and screened for assessing the resistance to powdery scab under field conditions from 2014 to 2018 in Yunnan, China. Each variety was planted with 10 plants in each of three plots. Resistance of potato was evaluated by measuring yield, disease incidence and disease index. Resistance performance was evaluated through the 5-year study period. Results showed that varieties with high level of powdery scab resistance included Mira, Lishu 6, Lishu 12, S10-843, Xuanshu 5, Lishu 1105, Lishu 14, Xuanshu 6, Huishu 9 and Yunshu 505. Yunshu 401, Qingshu 9, Hezuo 88 and S10-277 were susceptible to powdery scab. The transcriptome analysis of resistant variety Mira and susceptible variety Cooperation-88(S88) under the stress of Spongospora subterranea was carried out to explore the genes involved in regulating the resistance of powdery scab.
Replacing the unsustainable and wild-caught fishmeal with field cricket (Gryllus bimaculatus) meal in Catla (Catla catla) fry diet: Effect for growth, in vivo digestibility, carcass composition histopathological alterations and disease tolerance
Authors: Perera G. S. Champika , Afridin M. R. , Adikari A. M.A.N. , Heenatigala P. P.M. , Maduka K. L.W.T. , Dunusinghe S.B.K.
Published: July 2023

Insect meal has been identified as one of the cutting-edge alternatives to substitute fishmeal (FM) in aquafeeds. However, the potential of FM replacing with field cricket meal (FCM) related to Calta catla fry stage has yet to be researched. Therefore, an eight-week experiment was designed to evaluate the performance of C. catla fry (0.22 ± 0.04 g/fish). The protein content of the FM of the control feed (0FCM) was replaced with 35% (35FCM), 70% (70FCM), and 100% (100FCM) of FCM. All the fish were hand-fed by respective research diets 5% of the body weight twice daily. Results showed that FCM could replace wild-caught fishmeal (67.1 % crude protein) without adversely affecting growth performance, carcass composition, liver functions, and disease tolerance. Though in vivo protein digestibility significantly decreased (P<0.05) when the FCM percentage increased in the feed, it did not affect the performance of the fish. Therefore, FCM could be used to prepare fish-free feed in the C. catla fry stage. However, optimum technical know-how should be identified to certify the accessible and economically viable mass-scale production of FCM.
Development and validation of a risk prediction model for cefoperazone/sulbactam-related coagulation disorders in Chinese inpatients – A case-control study
Authors: Fu An , Ge Feng , Wang Yanwei , Guo Haili , Zhu Man , Li Shu , Gao Ao , Li Chao , Lu Jingchuan , Guo Daihong
Published: July 2023

Background and aim: Long-term use of cefoperazone/sulbactam (CPZ/SAM) may lead to vitamin K-dependent coagulation dysfunction which is significantly associated with increased risks of major bleeding and death. However, there is a lack of prediction models estimating the risk for this adverse drug reaction. This study aimed at developing and internally validating a risk prediction model for coagulation-related adverse reactions in Chinese inpatients treated with CPZ/SAM.
Methods: A case-control study was conducted in 11,092 adult inpatients admitted to our hospital from 2020 to 2021. We selected patients reporting coagulation-related adverse reactions through the Adverse Drug Events Active Surveillance and Assessment System-2 developed by our team. The final predictors were obtained by using the Least Absolute Shrinkage and Selection Operator (LASSO) algorithm. The prediction model was visualized as a static nomogram and a web-based dynamic nomogram. Internal validation and calibration were performed using bootstrap enhanced procedure with 1000 resampling.
Results: We found 215 coagulation-related adverse reactions (5.1%) in 4212 patients treated with CPZ/SAM. A final population of 208 cases and 624 controls was considered for model development and validation. Malnutrition, renal insufficiency, parenteral nutrition, longer treatment duration and red blood cell count were identified as final predictors. There is a nonlinear relationship between treatment duration and coagulation disorder. The model shows good discrimination and calibration, with the validated area under the receiver operating characteristic curve (AUROC)being 0.739 (0.699-0.779), p for Hosmer-lemeshow more than 0.05 and Brier score being 0.152. The decision curve analysis reveals that the net benefit of the model is higher, compared with the hypothesis that coagulopathy occurs in all patients with medication or no coagulopathy occurs.
Conclusions: The nomogram model quantifies the risk for coagulation-related adverse reactions in Chinese inpatients treated with CPZ/SAM, supporting individual assessment and interventions to mitigate the risk.
HERPUD1 as a potential prognostic biomarker in lung cancer and association with migration and invasion
Authors: Xiao Di , Zeng Xingruo , He Hengjing , Jamal Muhammad , Zhang Chengjie , Zhang Xiaoyu , Xie Songping , Zhang Qiuping
Published: July 2023

Lung adenocarcinoma (LUAD) is the most prevalent type of lung cancer with unfavorable prognosis. Endoplasmic reticulum (ER) stress and the tumor immune microenvironment (TME) contribute to cancer progression. However, the role of ER stress and TME in LUAD remains poorly understood. Utilizing bioinformatics analysis, we identified HERPUD1 as a promising candidate gene among ER stress-related genes. HERPUD1 was found down-regulated in lung cancer tissues compared to normal tissues, with low expression HERPUD1 serving as a poor prognostic indicator. Immunofluorescence analysis indicated the subcellular localization of HERPUD1 within the cytoplasm, ER and plasma membrane. Cell functional experiments indicated that HERPUD1 overexpression significantly inhibited lung cancer cells proliferation and epithelial mesenchymal transformation (EMT). To further investigate the underlying mechanisms of HERPUD1 in LUAD, we performed GO and KEGG enrichment analyses. These analyses unveiled that upregulated HERPUD1 inhibited the JAK2/STAT3 pathway. Furthermore, immune infiltration analyses showed that a positive correlation between HERPUD1 and B cells, CD8 T cells and NK cells. Chemokine analysis showed that HERPUD1 may recruit DCs, T cells and monocytes/macrophages, and reduce the polarization of macrophages and neutrophils. Notably, high HERPUD1 expression indicated favorable chemotherapy and immunotherapy response after immune checkpoint blockade treatment. Collectively, our findings shed light on the critical role of ER stress in the context of LUAD, emphasizing the significance of HERPUD1 as a prospective therapeutic target and prognostic biomarker in LUAD.
The main forest species encountered in southern and central Benin, west Africa
Authors: Gorgias AÏKPON , Kourouma KOURA , Jean GANGLO C.
Published: July 2023

Benin is a West African country with significant biodiversity resources. In this regard, research work is expected in order to better discover and document the country's biodiversity. This dataset provides information on the main forest species found in southern and central Benin, West Africa. These species are characteristic of forests and above all are of particular interest both to populations and to managers of protected areas. Field collections were initiated in 2007 as part of natural forest inventory work. The data collected has been completed by various field works that followed this work on forest species in southern Benin. The latest version of the dataset is publicly and freely accessible on the Gbif website at the address https://www.gbif.org/dataset/aff3a10a-a86b-4eff-98e4-d63f92fd6f7e.
Land suitability analysis for solar power plant using satellite imagery processing and GIS, Ardabil, Iran
Authors: Hasanzadeh Meysam , Kamran Khalil Valizadeh , Feizizadeh Bakhtiar , Mollabashi Sanam Hassanzadeh
Published: July 2023

Fossil fuel emissions have caused immense harm to the environment, making renewable energy sources like solar power essential. However, finding the optimal location for a solar power plant requires multi-criteria decision making (MCDM) due to various factors influencing the selection process. This study used the AHP method to weigh criteria such as GHI, Temperature, Elevation, Slope, Land cover, Distance from city, and Distance from road. The layers created from satellite imagery were combined using algebraic sums to produce a final map with 9 classes The analysis showed that class 9 has the most desirable values for each criterion, indicating the most suitable regions for a solar power plant. The results of the study have identified the southern and some central regions of Ardabil province as being the most suitable locations for the construction of a solar power plant. These regions have been found to have favorable values for the criteria studied, indicating a higher potential for solar energy generation. Based on the criteria assigned to class 9, the best lands have been identified, occupying a total area of 3085 hectares. This area represents approximately 0.17% of the total area of Ardabil province. These findings highlight the importance of careful site selection for solar power plants to ensure maximum efficiency and sustainability.
Effect of Household Packaging on the Antioxidant Parameters of the Organic and Conventional Cucumis Sativus L. : a Comparative Analysis
Authors: Das Suryatapa , Chatterjee Annalakshmi , Pal Tapan Kumar
Published: July 2023

Organic foods are becoming popular for their health benefits consumers perceived. But proper storage of organic fresh produce is essential to preserve the vital nutrients to sustaining health benefit. The present study was framed to show the effect of domestic packaging on antioxidant and antioxidant status of organic and conventional Cucumis sativus L. stored at different temperatures. The organic and conventional Cucumis were stored without any packaging, in Polypropylene (PP) Container, Low Density Polyethylene(LDPE) Zipper bag, and Cling film wrap at ambient temperature (250C) and low (4 0C) for 3 and 7 days. The ascorbic acid content, total carotenoids, total polyphenols, total flavonoids, tannin contents, and DPPH, ABTS, and FRAP antioxidant capacities were estimated. Results showed that the ascorbic acid, total carotenoids, tannin, and flavonoids were reduced during storage. The DPPH and FRAP antioxidant capacities were reduced significantly. Therefore, packaging at ambient and low temperatures creates a modified atmosphere within it, thereby can be considered as a devising strategy to preserve antioxidants in organic and conventional Cucumis at domestic level.
Differential Neurodevelopmental Trajectories in Patients With autism spectrum disorders and developmental language disorders: A large-sample study from China
Authors: Liu Zhimei , Zou Liye , Chen Aiguo , Herold Fabian , Taylor Alyx , Yu Qian , Chen Minhua , Wei Rongmei , Cai Kelong , Liu Yuexin , Chen Wei , Li Jinming
Published: July 2023

In children, both autism spectrum disorder (ASD) and developmental language disorder (DLD) are characterized by serious deficits in language development and have a certain overlap in their symptoms, it is often difficult to reach a clear diagnosis. In this study 3219 children with ASD and DLD were evaluated using the Gesell Developmental Diagnostic Scale (GDDS) and the Childhood Autism Rating Scale (CARS). We observed Children with ASD exhibited a lower score in five domains. And the CARS score shows negative low to moderate correlation with the five domains of the GDDS. Based on our findings, we deduce that GDDS combined with CARS assessment can be helpful for early screening and differential diagnosis of children with ASD and DLD.