bluuebunny/crossref_metadata_2025 huggingface dataset:
Renegade cellular and bacterial genetic sequences in monkey-derived stealth adapted viruses
Authors: Martin W. John
Published: March 2023

Stealth adapted viruses differ from the viruses from which they are derived in not being effectively recognized by the cellular immune system. This is because of the deletion or mutation of the genes coding for the relatively few virus components, which are generally targeted by cytotoxic T lymphocytes. Stealth adapted viruses do not, therefore, normally evoke inflammation, the hallmark of most infectious illnesses. A stealth adapted virus was repeatedly cultured from the blood of a patient with the chronic fatigue syndrome (CFS). Polymerase chain reaction (PCR) performed on the culture identified the virus as being derived from an African green monkey simian cytomegalovirus (SCMV). The PCR also amplified a genetic sequence closely related to a normal cellular gene. Further analysis of the viral DNA indicated that it was fragmented and genetically unstable. Moreover, additional genetic sequences have been incorporated into the replicating virus genome. Several of the additional sequences are originally of cellular origin with subsequent genetic modifications. Other incorporated sequences are of bacteria origin. PCR performed on cultures from some other CFS patients, led only to the amplification of modified cellular sequences, including a sequence apparently derived from the rhesus monkey genome. It is proposed that as part of the stealth adaptation process, sequences of the original infecting virus can be largely displaced by cellular and/or bacteria sequences, which have essentially switched their affiliation to that of the stealth adapted virus. For this reason, they are referred to as renegade sequences. The term “renegade viruses.” is also proposed to describe those viruses in which the originating conventional virus sequences have yet to be detected. The findings are relevant to efforts to seek a virus cause of many common illnesses, including CFS, and to the possible misattribution of certain illnesses to bacterial infections.
Recovery from Covid-19 and evolution, 03.22.2020
Authors: Benharroch Daniel , Benharroch Yane-Bianca , Goshen Ilai
Published: March 2023

Among the clinical categories described in the daily report by the W.H.O. on the incidence of COVID-19 worldwide, one concerns the number of recovering patients. However, in the subsequent accounts by various agencies, medical or otherwise, the data regarding convalescence are usually subdued. A relatively small proportion of recovery was noted in Germany and Israel and the query on the relevance of these figures was the basis of our investigation. The relative significance of the daily number of healing patients, as compared with the number of serious-critical patients and of death, together with the rate of these patients out of the total number of infected individuals were employed in our comparative study.
Comprehensive review on the evolution of SARS-CoV-2(COVID-19): From emergence, outbreak,molecular characterization to the clinical challenges in designing and developing potential drugs, vaccines and therapies to counter SARSCoV-2
Authors: Banerjee Pallabi , Singh Tripti , Singh Nagendra , Qamar Imteyaz
Published: March 2023

The outbreak of Coronavirus which initially began in China, in the year 2003 has caused several major public health concerns which resulted in epidemics globally, such as, severe acute respiratory syndrome (SARS) & Middle East respiratory syndrome (MERS). Most recently, i.e. in late December 2019, authorities identified an ongoing outbreak of the novel coronavirus (2019-nCoV), recently named as COVID-19 caused by SARS-CoV-2 which originated in Wuhan, Hubei Province, China. It probably marked the third highly pathogenic coronaviruses spreading globally, causing severe respiratory ailments and pneumonia-like infections in the humans.2019-nCoV exhibits similar genome organization, genetic, and epidemiological features to the other known CoVs. The COVID 19 virus has been declared as an inter-human transmissible virus which readily spreads mainly through the respiratory droplets produced when a person infected with coronavirus coughs, sneezes or talks. In a short stretch of time, this epidemic had spread to 210 Countries and Territories with 16, 20, 500 confirmed cases, including 97,400 confirmed deaths. Currently, the Mortality rate of COVID 19 is 2-5% only compared to SARS and MERS Coronaviruses. The older people are at a higher risk of COVID-19 infection due to their reduced immunity and body reserves, as well as multiple associated comorbidities like hypertension, diabetes, cancer and chronic obstructive pulmonary disorders. Till date, there is no effective anti-viral drug or licensed vaccine available to treat this infectious disease. As the infection is a recently advancing pathogen, several queries remain unanswered concerning the virus's reservoirs, pathogenesis, transmissibility, and much more is unknown. Herein, this article comprehensively reviews the currently available information on the virology, epidemiology, clinical presentation, diagnosis, and treatment of COVID-19.
Orbital inflammatory syndrome after mechanical thrombectomy of acute carotid occlusion
Authors: Silva Ana Rita , Costa Luís Rufo , Pinto Joana , Meira Torcato , Amorim José Manuel , Rocha Jaime , Alves José Nuno , Ferreira Carla
Published: March 2023

Introduction: Orbital ischemic syndrome (OIS) is a rare disorder that presents with acute loss of visual acuity, chemosis, proptosis, ptosis and ophtalmoparesis. We present a case with acute onset of orbital inflammation following mechanical thrombectomy that mimicked an OIS, except for the absence of vision loss. Case report: A 65-year-old woman presented to our emergency department after an episode of transient dysarthria and left-sided hemiparesis and paresthesia that lasted about forty minutes. Head computed tomography showed no signs of intracranial bleeding or acute ischemia. CT angiogram showed occlusion of the right ICA terminus. Mechanical thrombectomy was then performed and the clot was removed with combined technique. Eight hours later, she developed orbital pain, ptosis, chemosis and complete ophthalmoplegia of the right eye. She had no diplopia, visual acuity and funduscopic examination were normal and there was no audible bruit in the orbit. Brain MRI performed showed hyperintensity of orbital fat along with hyperintensity and enlargement of all the extraocular There were no signs of orbital infarction and the optic nerve was structurally normal. Time of flight magnetic resonance angiography revealed reduced calibre of the distal portion of ICA, with associated contrast enhancement on vessel wall imaging. She was started on intravenous dexamethasone with full recovery two days later. Discussion: We present the case of an orbital inflammatory syndrome after mechanical thrombectomy. The mechanical stress exerted by endovascular devices has been associated with endothelial damage that correlates with vessel wall thickening and contrast enhancement in high resolution MRI studies. The temporal correlation with mechanical thrombectomy, the absence of vision loss or orbital infarction and the good clinical response to steroids support the hypothesis of an internal carotid artery wall inflammation due to endovascular manipulation of the stent retriever to be responsible for this acute orbital syndrome. This case highlights the need for close postprocedural monitoring after MT and the consideration of orbital inflammation secondary to endovascular devices in the differential diagnosis of an acute orbital syndrome. Further studies are needed to understand the long-term consequences of arterial wall lesions associated with these devices.
Adaptation of the inventory of complicated grief in relatives of those who died from COVID
Authors: Aguinaga Arcos Sayuri Nicolle , Pérez Mori Dreyci Nathali
Published: March 2023

The general objective of this research was to determine the psychometric evidence of the complicated grief inventory adapted in relatives of the deceased by COVID - 19 of Lima East 2021. The sample consisted of 995 family members of deceased persons due to Covid-19, between 18 and 73 years of age, to whom the complicated Grief Inventory created by Prigerson (1995) was applied, adapted to the Colombian population by Gamba and Navia,1 the objective was to adapt the Complicated Grief Questionnaire to the Colombian population. A sample of 995 people was taken as a sample, 43.5 % women and 56.5 % men, average age up to 73 years (range = 18 to 73 years). Cronbach's alpha (a=.879), similar to the original test in English (a=.94) and higher than the Spanish adaptation (a=.88), as the inclusion of 21 items. Regarding the factorial structure of the test, the Kaiser Meyer - Olkin sample adequacy index (kmo=89) and Bartlett's test of sphericity (χ2=1702.133, p<.000), indicated that the factorial analysis was viable. Following the internal consistency method, Cronbach's alpha was .902, which is considered high reliability. It was possible to establish scales and percentiles of the psychometric evidence of the complicated grief inventory adapted in relatives of the deceased by COVID - 19 of Lima East 2021.
Hydrocephalus secondary to tumors of the posterior fossa: review article
Authors: Palacios Claudio A Rivas , Alvis Miranda Hernando R , Escobar Pacheco María Andrea
Published: March 2023

Posterior fossa (PF) tumors are a common cause of obstructive hydrocephalus. In adults, metastases are the most common tumors in PF. Among the primary neoplasms, the most common are meningioma, vestibular schwannoma, and hemangioblastoma. Glial tumors are the most prevalent in children and adolescents, followed by medulloblastoma and ependymomas. Surgical treatments are of choice in hydrocephalus due to posterior fossa tumors (HPFt). Tumor resection may be sufficient as monotherapy in adults with asymptomatic hydrocephalus and in others with a low risk of postoperative hydrocephalus. Endoscopic third ventriculoscisternostomy (ETV) is the choice for prophylaxis and / or treatment of HPFt in children-adolescents and adults. Ventriculoperitoneal bypass is beneficial in children-adolescents and adults with relative contraindications for EVT and / or unfavorable anatomy for it. External ventriculostomy is useful in adults who require emergency cerebrospinal fluid drainage.
Primary lumbosacral intradural hydatid cyst revealed by a cauda equina syndrome
Authors: Hmamouche O , Lakhdar F , Benzagmout M , Chakour K , Chaoui MF
Published: March 2023

Hydatid disease is a serious public health problem in developing countries. Spinal hydatid cysts account for 1% of all cases of hydatid disease and the primary intradural extramedullary hydatid cyst is exceptional. We report a case of 75-year-old women presented with a history of backache, leg pain, difficulty in walking, and bladder incontinence. Thoraco-lumbar MRI has showed an intradural process extending from L2 to S5, a low intensity signal on T1 weighted images and a high-intensity signal on T2 weighted images, which were not enhanced after gadolinium injection. There was no vertebral involvement. The patient underwent surgery, by a posterior approach we perform L2S1 laminectomy. After opening the dura multiple vesicles were found scattered among the roots, with no adhesion to meninges or nervous structures. The outcome was good. Albendazole therapy is obligatory.
Rhino-orbito-cerebral mucormycosis (black fungus) in covid 19 patients in western Uttar pradesh India
Authors: Srivastava Mohit , Gupta Keshav , Singh Veenita
Published: March 2023

Mucormycosis (Black fungus) is a designated as a rare, rapidly progressive fatal disease of immunocompromised caused by saprophytic fungus of family mucorales. Early diagnosis with prompt medical and surgical treatment is the only tool available. Rhino-orbito-cerebral is the most common subtype. In India we saw a sudden rise in mucormycosis cases during second wave of COVID 19. This necessitated a systematic review of epidemic of mucormycosis in COVID 19. A Retrospective multi-centric study was conducted comprising of 51 cases of Rhino-orbito-cerebral mucormycosis with present or recent COVID19 in Western Uttar Pradesh positive status presenting to us during 14th April 2021- 31st May 2021. Either Type2 Diabetes Mellitus or history of recent use of steroids in high doses was present in all the patients. Contribution of virulence of the Delta strain B1.617.2 is significant. FESS with sino-nasal debridement contributes significantly towards mortality reduction and cost of total treatment by significantly reducing days of Liposomal Amphotericin B therapy. Early diagnosis with prompt medical and surgical management along with blood sugar control and avoiding use of high dose of steroids remain to key to mortality and morbidity reduction.
From pioneers to modern medicine: tracing the evolution of our understanding of the relationship between Eustachian tube dysfunction, alternobaric vertigo, and laryngopharyngeal reflux
Authors: Kim Hee-Young
Published: March 2023

Decades of research have been devoted to understanding the complicated connections between the ears, nose, throat, and stomach. Pioneers in the discipline of otolaryngology/ear, nose, and throat (ENT), James Yearsley (1805–1869) and Peter Allen (1826–1844), produced theories and concepts that allowed us to determine the relationship between these items. The current study has contributed to clarifying the complex relationship between Eustachian tube dysfunction (ETD), alternobaric vertigo (ABV), gastroesophageal reflux disease (GERD), laryngopharyngeal reflux (LPR), and nasopharyngeal reflux (NPR). These interrelationships are required for guiding otolaryngology research and improving patient care. This article investigates the historical and contemporary links between ETD, ABV, and LPR. James Yearsley developed the concept of "stomach deafness" in 1843, suggesting a relationship between stomach issues and hearing loss. Peter Allen thought that ETD might be related to vertigo, especially "alternobaric vertigo," which happens when the air pressure changes in the labyrinth and affects the fluid in it. Recent investigations have shown that NPR or LPR can produce ETD and ABV by irritating and inflaming the Eustachian tube. For otolaryngology research to progress and patient care to improve, it is critical to understand both the historical and modern perspectives on these complex interactions.
Chemotherapy delivering port catheter fracture and migration into the heart: a life-threatening accident during neck dissection
Authors: Dhaha Mohamed , Zahmoul Asma , Jbeli Souheil , Methnani Alia , Brahem Rim , Dhambri Sawsen , Kedous Skander
Published: March 2023

Objectives: port catheter fracture and migration could be an iatrogenic life-threatening complication. We aimed to sensitize head and neck surgeons to this complication. Observation: a 61-years old man was referred to our surgery department for management of T3N0M0 laryngeal cancer after failure of preservative treatment. The patient had received 2 cycles of chemotherapy and was judged a bad responder. A total laryngectomy with bilateral neck dissection was indicated. The port catheter was kept in place for possible further chemotherapy treatment. During neck dissection the catheter fractured and migrated. Post operative CT scan showed the distal part of the catheter bulging in the right cardiac chambers. The patient was transferred to an interventional cardiology unit where the foreign body was successfully retrieved using femoral venous access. Conclusion: port catheters are a real potential danger because of the risk of fracture and migration of the distal part. Removal of these devices should be performed in collaboration with medical care oncologists before every neck intervention.
On the issue of objective diagnosis of dissociative identity disorder in the practice of forensic psychiatry
Authors: SV Rosman
Published: March 2023

The article presents the possibilities of a new method of neurophysiological research in forensic psychiatry – the variance of the amplitude-frequency characteristics of the alpha rhythm of the EEG on the example of a dynamic study of a patient with dissociation of personality identification.
Local wind in urban canyons of a residential area in Quito-Ecuador
Authors: Campoverde Andrés Bustamante
Published: March 2023

This study evaluates the behavior of the wind from its speed in representative urban canyons of residential buildings in the city of Quito. The methodology was based on the selection of case studies from the area of Concepción located in the north of the city to build simplified models according to their aspect ratio height / width (H / W) in blocks of 250 m by 250 m. In each case includes multiple configurations of urban canyons, giving priority to the west-east and north-south orientations, which are simulated by the application of Computational Fluid Dynamics (CFD). The local wind is evaluated according to pedestrian height and their predominant direction obtained from the historical information obtained from the weather station in the area. The results show that the predominant relationship of the wind retains higher speeds when it flows canyons with a lower H/W ratio.
Effect of drying on the yield and chemical composition of essential oils obtained from Mentha Longifolia leaves
Authors: Singh Sunita
Published: March 2023

The present study was carried out to evaluate the influence of the drying mode (under the sun) on the yield and composition of essential oils extracted from leaves (fresh and sun dried) of Mentha longifolia. Drying under the sun increased the concentration of essential oils isolated by hydrodistillation in a Clevenger apparatus. Twenty-three components were identified by using gas chromatography (GC) and GC coupled to mass spectrometry (GC–MS). The chemical composition was dominated by the presence of piperitenone oxide, in both essential oils obtained from fresh and sun dried mentha leaves. These results showed that the drying has a significant variation on essential oils yield and affected the qualitative and quantitative constituents of their composition.
The preservative effect of Aframomum danielli spice powder on the chemical, microbial and sensory properties of Groundnut butter
Authors: Bello Florence A , Ndah Linus S , Irem-Oka Jessica A
Published: March 2023

The effect of natural preservative (Aframomum danielli) on the chemical, microbiological and sensory properties of stored groundnut butter was investigated. Raw groundnut seeds were processed traditionally into a paste (butter) and Aframomum danielli powder was added at the concentration levels of 0.20%, 0.40% and 0.60% and labeled as samples B, C and D, respectively while sample A (without Aframomum danielli powder) was prepared as control. The samples were stored at ambient temperature and evaluated at 1, 10 and 20 days for proximate composition, peroxide value, microbial and sensory properties. The moisture and crude protein content increased with increase in concentration of Aframomum danielli powder on day 1 and decreased on day 10 and 20 with sample D having the least values. Crude fat and crude fibre content increased significantly (p<0.05) as the concentration increased but decreased as storage day increased, with sample D having the highest value. Increase in A. danielli powder also increased the ash content of the treated samples and decreased the carbohydrate content. Peroxide value decreased with increase in concentrations with sample D having the least peroxide value. Bacterial and fungal count decreased significantly (p<0.05) as the concentration increased, with sample D having the least microbial count. All the samples were judges as acceptable but sample D was most preferred. A. danielli when used at 0.60% is more effective as a natural preservative in groundnut butter without objectionable attributes in sensory properties.
Nano-delivery system for bioactive compounds
Authors: Khan Irfan , Haque Abdul , Ahmad Saghir
Published: March 2023

The scientific community is searching, discovering and inventing things for the welfare of humanity in pursuit of sustainable solutions to respective problems. Among the factors relating to human life, human health is the most concerned issue. Each country is investing a significant amount of money in research and development to improve the human health. Besides having appropriate amount of nutrients, the most important aspect of food is the bioavailability of nutrients. Food item rich in natural antioxidants but not accessible to human body is wasteful. Thus, nanotechnology has shown great potential to improve the efficiency of delivery system of bioactive components to the human body. In this article, an effort has been made to discuss the applications of nanotechnology in the delivery of bioactive compounds to improve the human health. Today, the pharmaceutical companies have started the manufacturing of nutraceuticals to treat the number of anomalies in human body. The nutraceuticals are the food, carrying densely packed bioactive compounds. The bioactive compounds help to fight against number of noncommunicable diseases such as cancer, diabetes, osteoporosis, arthritis and cardiovascular diseases. The action of bioactive compounds depends upon the extent of bio accessibility or bioavailability to the human body. In this context, nanotechnology play crucial role by manipulating bioactive compounds in the dimensions of 1-100 nm. The typical example of nano-delivery system is the liposomes, lipid vesicles, can incorporate variety of bioactive compounds in their interior. The exceptional capability of nanotechnology is paving a path of new technologies that may affect the human lives by various means. By improving the delivery efficiency of bioactive agents, nanotechnology can be a breakthrough technology in the world of food medicine.
Abiotic stress tolerance in horticultural crops by phyto-beneficial microbial inoculants: a review
Authors: Mishra Brijesh Kumar , Saxena SN , Kant Krishna
Published: March 2023

Many agricultural crops at global level are exposed to numerous abiotic stresses such as extremely high or low temperature, salinity, drought, acidic soils, and metal toxicity. Depending on the type of crop, such abiotic stresses result in yield losses in tune of 50 to 82%. It is widely recognized that microbes perform crucial roles in biogeochemical cycling; the impact of microbes on plant productivity and diversity is still need to understand. The role of microbial inoculants in plant growth promotion, nutrient management and disease control is very well studied. These beneﬁcial microorganisms colonize the rhizosphere /endorhizosphere of plants and promote growth of the plants through various direct and indirect mechanisms. Microorganisms could play a significant role in this respect; if suitably exploit their unique properties of tolerance to extremities. It is therefore, very essential to explore the soil microbial diversity and the various modes of actions involved in direct and indirect plant growth promotion and develop consortium of two or more phyto-beneficial microbes to attain maximum benefits from microbial inoculation. The present review article provides concise updated information on Phyto-beneficial microbial inoculants in food production system especially horticultural crops.
Development, quality assessment and antioxidant properties of cocoa based beverage produced from vegetable milk
Authors: Oluwadunsin Olugbuyi Ayo , David Oluwajuyitan Timilehin , Ayobamidele Badejo Adebanjo , Nathaniel Fagbemi Tayo
Published: March 2023

Developing countries are faced with the challenge of diet related diseases like diabetes mellitus, cancer, cardiovascular diseases and inadequate protein in their diet. The common beverage produced from animal milk was reported to have bad cholesterol which may lead to hypertension, hence the need to develop beverage from plant sources. Cocoa based beverage was developed from of Tigernut tubers (Cyperus esculentus), Soybean (Glycine max) and Alkalized Cocoa Powder sweetened with either natural or synthetic sweeteners (Date syrup, Sucrose and Aspartame). A commercially available sample was used as control. Physicochemical, amino, fatty, antioxidant properties and sensory evaluation were carried out using standard methods. The protein content of the formulated beverage ranged from 3.12g/100g in TCSW to 9.58g/100g in TCS and were significantly higher (p<0.05) than TSBD (2.12g/100g) which was the control sample ;while Energy values (Kcal) ranged from 84.529kcal/100g in SCS to 468.51kcal/100g in TCS. The total phenolic content ranged from 136.11mg/g in SCS to 161.37mg/g in TCDS but was slightly lower than TSBD (165.85mg/g). In conclusion, the study established that the formulated beverage exhibited high amino acid profile and low fatty acid composition; hence the beverage drink may be suitable as functional foods for both old and young.
Therapeutic effect of cranberry active components on E.coli urinary tract adhesions: A review
Authors: Basharat Shahnai , Khalid Ayesha , Sohail Aiman , Wahab Khadija Abdul , Ali Muhammad , Omer Areesha , Qureshi Aleena , Nadeem Raida , Sajjad Huma , Anmol Sanabil
Published: March 2023

Cranberry (Vaccinium spp.) has been used by North American Indians to treat many medicinal properties. It is also recommended for the treatment of urinary tract infection (UTI) which is caused by adhesion of bacteria called Escherichia coli. We conducted this meta-analysis to assess the effect of cranberry in preventing the adhesion of E. coli in the urinary tract. Cranberry appears to work by inhibiting the adhesion of type I and P-fimbriated Escherichia coli to the uroepithelium, thus hinder the colonization and upcoming infections. Adhesion is prevented by 2 ingredients of cranberries: laevulose that prevents binding of type 1 fimbriae and pro-anthocyanidins, which prevents p- fimbriae binding. The anti-adherent effect began in 2 hours and remains for up to 10 hours after consumption. These results suggest that cranberry can be an effective in preventing and treating urinary tract infections; however, larger high-quality studies are needed to confirm these findings.
Determinants of under–five mortality in south–eastern Nigeria
Authors: EC Azuike , PEN Onyemachi , CC Amah , KC Okafor , JO Anene , KG Enwonwu , RC Aniemena , NE Arua , AL Ilika
Published: March 2023

Background: Under–five mortality is a major public health indicator hence its inclusion among the Sustainable Development Goals (SDGs). Identifying the determinants of under–five mortality is a major step in tackling under–five mortality. While it is important to determine factors that affect under–five mortality at the national level, is it also very important to disaggregate data to determine the peculiarities and differences at the geopolitical zones. This zoomed into the South–eastern geo–political zone of Nigeria. Methods: This was a population based cross–sectional study. Secondary data of the 2013 Nigeria Demographic and Health Survey (NDHS) was analyzed. Though the NDHS was a nationally representative study, only data from the South–east geo–political zone was included in analysis. The aim of the study was to identify determinants of under–five mortality. Univariate and multivariate logistic regression were carried out. Results: This study revealed several determinants of under–five mortality in the South–east geo–political zone of Nigeria. Children who reside in Anambra state had lower odds of under–five mortality compared with the children who reside in the four states. The following factors reduced the odds of under–five mortality: female gender, maternal education, maternal age less than 35years, maternal use of modern family planning, family belonging to the middle and rich wealth index. Conclusions: this study has identified important risk factors that should be considered in the formulation of policies that combat under–five mortality in the South–east geo–political zone of Nigeria.
Use of the PCSK9 inhibitor, evolocumab, in patients with heterozygous familial hypercholesterolemia
Authors: Srinivasan Sneha
Published: March 2023

Evolocumab is a monoclonal immunoglobulin G2 that acts against human proprotein convertase subtilisin/kexin type 9 (PCK9) used against Homozygous familial hypercholesterolemia and Heterozygous familial hypercholesterolemia in high cardiovascular disease risk patients with increased level of triglycerides. Evolocumab is administered subcutaneously 420mg every month and 140 mg twice a week in patients with HeFH as evaluated by RUTHERFORD and RUTHERFORD 2 trials. This paper reviews the six clinical trials of evolocumab that evaluated the efficacy of the drug for heterogenous familial hypercholesterolemia.
The nature of science dimension in the teaching discourse. a case study
Authors: Cutrera Guillermo
Published: March 2023

Spoken language is the vehicle through which a great deal of teaching takes place, as well as the way in which students show the teacher a great deal of what they have learned. In this context, teaching is mostly a means of providing access to those specific ways of speaking. In particular, metadiscourse is a discursive resource used in discursive exchanges in science classrooms. Despite its importance, metadiscourse has been poorly studied in the science classrooms. One of the metadiscourse methods studied in classrooms is the one corresponding to epistemic markers. The purpose of this study is to analyze how a future Chemistry teacher uses metadiscourse to build scientific knowledge along with the students. A qualitative study of the future teacher’s speech was undertaken from discursive exchanges in a physical chemistry classroom. All classes were video and audio recorded for analysis purposes. From total of four classes, a number of extracts were selected from the third class. Based upon a content analysis, representative categories of epistemic markers in the teacher's verbal discourse were inferred. Discourse markers referred to the scientific law recognition as well as its structure and physicochemical properties thay either vary or remain constant during the phenomenon occurence were found. These markers show the importance of considering an explicit work with the epistemic dimension of the content in order to promote the construction of scientific explanations understanding in the science classroom. Additionally, this importance implies the relevance of engaging the future teachers in reflective practices that demonstrate the work with the nature of science from the discursive use of epistemological markers.
Türkiye’de Türk Sineması Üzerine Yazılan Yüksek Lisans, Doktora ve Sanatta Yeterlik Tezleri Üzerine Bir Araştırma
Authors: İŞLER SEVİNDİ Meltem , SEVİNDİ Koray
Published: March 2023

Yapılan araştırmanın temel amacı, Türkiye’de Türk sinemasını konu alan ve YÖK Ulusal Tez Merkezi veri tabanında erişilebilir olan yüksek lisans, doktora ve sanatta yeterlik tezlerinin çeşitli başlıklar altında değerlendirilmesi ve incelenmesidir. Bu amaca uygun olarak tezlerin genel profillerine, konularına ve belirlenen başlıkların tarihsel süreçteki değişimlerine bakılmıştır. Çalışmada tez türüne yönelik bir sınırlandırmaya gidilmemiş ve yüksek lisans, doktora ve sanatta yeterlik alanındaki bütün tezler incelenmiştir. Makalede, nitel araştırma yöntemlerinden biri olan doküman inceleme yöntemi kullanılmıştır. Temelde dokuz farklı tablo oluşturulmuş ve bu tablolarda elde edilen bulgular üzerinden değerlendirmeler yapılmıştır. Tablolara konu olan başlıklar: tezin savunulduğu yıl, tezin yazıldığı üniversite ve anabilim/anasanat dalı, tezin yazım dili, tezin konu aldığı film türü, tezin inceleme alanındaki Türk sineması dönemi, tezde temel alınan ve tez başlığında yer alan kişiler ve filmler ile tezin araştırma alanındaki temel konulardır. Sadece üretilen tezlere yönelik sayısal bilgilere ulaşılmamış, aynı zamanda tezlerin ele aldığı konular ve bu konuların tarihsel süreçte nasıl ortaya çıktığı ve farklılaştığı da gözlemlenmiştir. Böylece akademik çalışmaların analizi ve incelenmesi ile Türk sinemasının akademik dünyadaki karşılığı ve yansımaları üzerine de fikir elde edilmiştir. Ayrıca, Türk sinemasını konu alan tezlerin içeriği konusunda araştırmacılara bilgi sağlanması, teze konu olan kavramların tarihsel süreçteki seçilme eğilimlerinin belirlenmesi, Türk sineması üzerine yapılan akademik çalışmalar konusunda genel bir bakış açısı oluşturulması, Türk sineması üzerine çok fazla çalışılan ve pek fazla ilgi duyulmayan alanların saptanması ve böylece yeni akademik çalışmalar için yönlendirme yapılması amaçlanmıştır.
Roundtable on the Archive: A Group Discussion from the Fourth Critical Genealogies Workshop (Richmond, VA, 2022)
Authors: Koopman Colin
Published: March 2023

This article is based on a transcription of a roundtable conversation on archival work and the concept of the archive held at the Fourth Meeting of the Critical Genealogies Workshop in Richmond, Virginia, on October 21, 2022. The roundtable panelists were Ladelle McWhorter, Kevin Olson, Verena Erlenbusch-Anderson, Perry Zurn, and William A.B. Parkhurst, all in conversation with the roundtable's moderator, Colin Koopman. Full participant biographies are appended at the end of the article.
Working-Through Wellness: Critical Perspectives on the Contemporary Wellness Dispositif
Authors: Bstieler Michaela , Crepaldi Gianluca
Published: March 2023

In this paper, we examine the institutionalised demands and imperatives that govern the contemporary working subject. Our starting point is the thesis advanced by both Alain Ehrenberg and Eva Illouz that since the 1960s institutions are no longer characterised by a strict culture of prohibition and discipline. Instead, institutions seem to be increasingly animated by the norms and practices of a "culture of self-care", enriched by therapeutisation (Ehrenberg) and emotionalisation (Illouz). However, this does not mean that the disciplinary regimes that Foucault focuses on are simply disappearing. They persist, albeit in a different form, and we demonstrate this by looking at three central aspects of contemporary wellness: (a) specific spatial arrangements, (b) the performance of bodily practices and techniques and (c) ritualised interactions. We argue that in wellness facilities disciplinary regimes become effective through interpellations that are inscribed in rigid temporal-spatial orders and demand the body's docility. Insofar as this process relies on those norms that Ehrenberg and Illouz reserve for post-Fordist labour, the wellness space can ultimately be understood as a labour space. For what is at stake is the productivity of the subject.
How Do Different Ingredients and Additives Affect the Production Steps and the Bioactive Potential of Mead?
Authors: Simão Larissa , da Silva Monteiro Wanderley Bruna Rafaela , Vieira Michelly , Haas Isabel Cristina da Silva , Amboni Renata Dias de Mello Castanho , Fritzen-Freire Carlise Beddin
Published: March 2023

Mead is a fermented alcoholic beverage that is made from honey diluted in water and commonly with the addition of other ingredients. The chemical characteristics of mead are closely related to the ingredients and additives that are used in its preparation, especially the type of honey, yeast strain and prefermentation nutrients, as well as herbs, spices and/or fruits. These additives can affect not only the fermentation process, in particular the yeast activity, the formation of metabolites and fermentation time, but also the bioactive potential of the mead, which mainly depends on phenolic compounds. Scientific studies have shown that the mead with added different plant species contains considerable amounts of different classes of polyphenols, which have important biological activities. Within this context, this review study seeks to investigate how different ingredients and additives can affect each of the stages of the preparation of mead, as well as its bioactive potential, in order to understand the effects on its chemical composition, and thus add greater commercial value to this beverage.
Evaluation of the Probiotic Properties of Lacticaseibacillus casei 431® Isolated from Food for Special Medical Purposes
Authors: Leboš Pavunc Andreja , Penava Lenkica , Čuljak Nina , Banić Martina , Novak Jasna , Butorac Katarina , Ceilinger Marijana , Miličević Jelena , Čukelj Danijela , Šušković Jagoda , Kos Blaženka
Published: March 2023

Research background. Increasing awareness of the importance of nutrition in health promotion and disease prevention has driven to the development of foods for special medical purposes (FSMPs). In this study, the probiotic strain Lacticaseibacillus paracasei ssp. paracasei (Lacticaseibacillus casei 431®) was incorporated into FSMPs to develop an innovative product. The aim was to investigate the influence of the FSMP matrix on the specific probiotic properties of L. casei 431® in vitro.
Experimental approach. A series of in vitro experiments were performed as part of the probiotic approach. After evaluation of antibiotic susceptibility profiles, functional properties such as survival under simulated gastrointestinal tract (GIT) conditions, bile salt deconjugation activities, cholesterol assimilation, antagonistic activity against spoilage bacteria and adhesion to Caco-2 cell line monolayers and extracellular matrix proteins were investigated.
Results andconclusions. The L. casei 431® strain, both the lyophilised strain and the strain isolated from the FSMP matrix, effectively survived the simulated adverse gastrointestinal conditions without significant effects of the food matrix. The effect of the FSMP matrix on the deconjugation activity of the bile salts of L. casei 431® was minimal; however, cholesterol assimilation was increased by 16.4 %. L. casei 431® had antibacterial activity against related lactic acid bacteria regardless of whether it was used in FSMPs or not. Conversely, the probiotic strain isolated from FSMP matrix had significantly higher inhibitory activity against six potential pathogens than the lyophilised culture. The autoaggregation ability of the L. casei 431® cells was
not affected by the FSMP matrix. The adhesion of L. casei 431® bacterial cells to the extracellular matrix proteins was reduced after treatment with proteinase K, with the highest adhesion observed to laminin. The adhesion of L. casei 431® reduced the binding of E. coli 3014 by 1.81 log units and the binding of S. Typhimurium FP1 to Caco-2 cell lines by 1.85 log units, suggesting the potential for competitive exclusion of these pathogens.
Novelty and scientific contribution. The results support the positive effect of the FSMP matrix on the specific probiotic properties of L. casei 431®, such as antibacterial activity, bile salt deconjugation and cholesterol assimilation, while the incorporation of this probiotic strain adds functional value to the FSMPs. The synergistic effect achieved by the joint application of L. casei 431® and innovative FSMP matrix contributed to the development of the novel formulation of an improved functional food product with added value.
L’imprévisible dans l’enseignement des langues ayant recours aux nouvelles technologies
Authors: GUO Jing
Published: March 2023

Fondée sur deux exemples d’exploitation des dispositifs numériques dans deux universités en France, nous apporterons quelques réflexions sur l’intégration des nouvelles technologies à l’enseignement / l’apprentissage des langues. En prenant appui sur les recherches didactiques, psychologiques et psycholinguistiques, nous proposerons des pistes de réflexion pour une meilleure alternance des démarches prévisible et imprévisible dans le but de favoriser l’apprentissage / l’acquisition.
L’imprévisible dans l’improvisation théâtrale multilingue
Authors: TAMUSSIN Catherine
Published: March 2023

L’improvisation théâtrale multilingue a incité les stagiaires (enseignants et futurs enseignants de langues) à chercher des solutions créatives inattendues pour se comprendre au-delà du sens des mots. Elle a développé une capacité d’attention réceptive à l’instant présent qui ouvre à des ressources intérieures insoupçonnées et favorise l’entrée directe dans la langue de l’autre.
Réflexions sur la place du texte littéraire dans la formation de futurs enseignants de FLE
Authors: BAKEŠOVÁ Václava
Published: March 2023

Dans le contexte de la formation actuelle de futurs enseignants de FLE, les textes littéraires, documents authentiques, acquièrent de nouveau un rôle important, celui d’un support didactique riche véhiculant la culture. En cela les textes sélectionnés peuvent apporter des réponses à différents types de questions, prévisibles ou / et imprévisibles. Or, comment l’usage des textes littéraires s’intègre-t-il dans cette formation ? Comment l’étudiant peut-il faire le transfert entre le texte et les objectifs didactiques et culturels ? Ce sont les questions sur lesquelles nous nous pencherons dans cet article.
Le prévisible et l’imprévisible dans l’enseignement du vocabulaire de spécialité
Authors: ČERVENKOVÁ Marie
Published: March 2023

Dans cet article sont présentés des principes clés de l’approche lexicale de l’enseignement / l’apprentissage du français de spécialité. Diverses stratégies d’enrichissement du vocabulaire et de l’identification des mots dans le contexte basées sur la prévisibilité sémantique, formelle et phrastique facilitent l’apprentissage. La seconde partie de l’article résume des activités lexicales réceptives et productives possibles qui permettent le développement et l’ancrage du vocabulaire.
Le prévisible et l’imprévisible dans la préparation des stages en France
Authors: DELALANDE Hana
Published: March 2023

Dans cette contribution, les résultats d’une recherche qualitative auprès des étudiants du master franco-tchèque d’administration publique qui partent en stage professionnel en France seront analysés selon les critères fondés sur des attentes prévisibles et imprévisibles. Suivant les conclusions de cette analyse, nous avancerons que l’imprévisible du déroulement des stages professionnels peut devenir prévisible grâce à une meilleure préparation de ceux-ci.
Du prévisible à l’imprévisible
Authors: WOLF-MANDROUX Françoise
Published: March 2023

Dans les Instituts Universitaires de Technologie (IUT) de France, les langues de spécialité sont enseignées, développant compétences à la fois universitaires et professionnelles. Les innovations numériques rendent l’enseignement-apprentissage des langues plus dynamiques et la mobilité internationale les renforce. Des étudiants ont créé le site Réseau Alumni Mobilité internationale (RAMI), projet innovant dont nous allons présenter les différentes étapes.
Prévisibilité / imprévisibilité dans le système linguistique slave
Authors: POGNAN Patrice
Published: March 2023

Grâce à l’expérience de la grammaire historique des langues slaves de l’Ouest et de la grammaire comparée de ces langues, issue de l’enseignement de la grammaire tchèque et de son traitement automatique, l’évolution ou plutôt la disparition de certains phénomènes est prévisible. À l’inverse, si de grandes tendances telles que l’analogie et l’agglutination sont (pré-)visibles, leurs réalisations concrètes sont imprévisibles.
Une signification prévisible, mais pour des sens imprévisibles
Authors: RACCAH Pierre-yves
Published: March 2023

Dans ce chapitre, nous verrons que les langues humaines ont toutes une propriété, appelons-la p, apparemment paradoxale, selon laquelle :
p une langue permet à qui sait l’utiliser de produire des énoncés imprévisibles et pourtant compréhensibles par les autres utilisateurs de cette langue.
Ce chapitre présente quatre caractéristiques essentielles des langues humaines, qui, confirmant la remise en question de la conception transmissionnelle des langues (assimilant notamment la signification des segments linguistiques au sens de leurs énoncés), amènent à lui préférer une conception manipulatoire s’appuyant sur le concept de point de vue… et qui semblent rendre p encore plus paradoxale. Après avoir vu pourquoi ces quatre caractéristiques, loin de permettre de réfuter la propriété p, la rendent, au contraire, … prévisible, nous examinerons la portée de ces réflexions sur quelques aspects de l’acquisition des langues secondes, aspects liés à la question suivante : comment faire acquérir la sémantique, complexe mais nécessairement prévisible (nous verrons pourquoi), d’une langue à apprendre, de manière à favoriser la production et la compréhension de discours, aux sens nécessairement imprévisibles (nous verrons aussi pourquoi). Nous tirerons de ces résultats, d’une part, quelques enseignements sur les progrès que nous avons à faire dans notre manière de concevoir les langues et leur utilisation, et, d’autre part, une stratégie visant à aider l’enseignant à consolider l’acquisition de la sémantique
Pour aborder l’étude de l’articulation entre prévisible et imprévisible en matière de sens
Authors: SIMONFFY Zsuzsa
Published: March 2023

Cette réflexion propose d’envisager la nature de la polarité de l’imprévisible et du prévisible tout particulièrement dans ses rapports épistémo-méthodologiques. Mon objectif est d’esquisser, à travers cette réflexion, une piste possible afin d’élaborer des outils heuristiques en sciences du langage. Dans cette perspective, ces deux termes nous rappellent d’autres couples de termes comme « général vs particulier », ou « nécessaire vs contingent ». Je tenterai d’apporter quelques éclairages sur la manière dont les acquis de la recherche linguistique peuvent être rentabilisés dans l’enseignement des langues étrangères. Si les notions de sens, de signification et de culture utilisées dans une perspective didactique gagnent à être adoptées et retravaillées dans leur dimension proprement linguistique, c’est pour prévoir comment rendre l’apprenant disponible à l’organisation des discours et comment parfaire sa capacité de construire du sens sans nécessiter de le transformer en épistémologue ou en linguiste.
L’imprévisible comme composante de sens
Authors: NAGY Andrea
Published: March 2023

S’appuyant sur les principes de la linguistique textuelle (Adam 1987–2013 ; Tolcsvai 2001), notre article présentera les deux principaux types – prévisible et imprévisible – d’organisations méso-textuelles des séquences évoquant des souvenirs. L’analyse textuelle d’extraits littéraires vise à montrer que le caractère prévisible ou imprévisible de la structure narrative relatant des souvenirs est à interpréter comme une composante pragmatique dans le sens global de l’œuvre littéraire.
Peut-on prévoir l’imprévisible?
Authors: SZÁSZ Géza
Published: March 2023

Des textes philosophiques du XVIIIe siècle insistent sur l’importance des voyages dans la connaissance du monde, sur la nécessité d’organiser l’observation et l’écriture, afin de minimiser l’imprévisible. Or, le récit de voyage serait incomplet sans l’évocation des éléments fortuits. Basé sur une typologie de l’imprévisible et sur l’analyse des Voyages en Hongrie, l’article propose de prendre en compte les modalités de la présence de l’imprévisible, et souligne l’arbitraire de l’auteur dans leur présentation.
Du prévisible à l’imprévisible : l’apparition du vers libre dans la poésie française
Authors: SZILÁGYI Ildikó
Published: March 2023

L’apparition du vers libre dans la poésie française à la fin du XIXe siècle anticipe le passage d’un système métrique prévisible à un système imprévisible. Nous proposons de placer les principales théories du vers libre (Kahn, Roubaud, Murat) et les pratiques observées dans une perspective historique, pour montrer les enjeux esthétiques, sociologiques et politiques de cette transformation. Après avoir évoqué les débats passionnels que l’émergence du vers libre a soulevés, cet article abordera les rapports entre la modernisation de la société et la « crise de vers » à travers les prises de position de Rimbaud, Verlaine et Mallarmé. Pour finir, nous illustrerons l’indétermination prosodique du vers libre par Apollinaire.