bluuebunny/crossref_metadata_2025 huggingface dataset:
Serum vitamin D level and female teenage caries experience: a cross-sectional study in Iran
Authors: Ahmadi Elham , Mirzaei Khadijeh , Yekaninejad MirSaeed , Fallahi Sasan , Omrani Ladan Ranjbar , Kermanshah Hamid , Mahmood Mahboobeh , Nouri Mohadeseh
Published: September 2024

Aims: This study aimed to assess Serum Vitamin D level and female teenage caries experience.
Methods: This study evaluated 330 healthy female Iranian students between 13 to 19 years residing in Rey city. A questionnaire collected their demographic information. They underwent clinical dental examination to determine the number of decayed (D), missing (M) and filled (F) teeth (DMFT index). The nutritional status was evaluated using the food frequency questionnaire(FFQ) by assessing the consumption of cariostatic, cariogenic, remineralizing, sticky foods and carbohydrates. The serum samples were collected to measure the serum vitamin D level using high-performance liquid chromatography(HPLC). Data were analyzed by multiple logistic regression and independent samples t-test.
Results: The mean DMFT was 5.34±3.94. Of all, 69.3% had severe vitamin D deficiency, 20.3% had moderate vitamin D deficiency and 10.4% had normal level of vitamin D. Cariostatic agents consumption had a significant inverse correlation with DMFT (P=0.006). An increase in serum level of vitamin D by more than 10.27 ng/mL was associated with a reduction in prevalence of dental caries by 22%. Increased consumption of cariostatic agents by more than 89.30 g/day decreased the prevalence of dental caries by 32%. No significant association was noted between the prevalence of dental caries and level of parent’s education, consanguinity of parents, level of income, place of residence, frequency of tooth brushing, dental flossing, and dental visits (P>0.05).
Conclusions: While the serum vitamin D level had no significant effect on DMFT, the nutritional regimen seemed to play a more important role in caries control.
INTRAOSSEOUS EPIDERMOID CYST OF JAW – A case report
Authors: Uppala Divya , Sivakalyan U , Sreevalli UDN , Varshita B Harika , Tirumalareddy Mounica
Published: September 2024

Abstract
Epidermoid cysts are benign, rare which can occur all throughout the body of an individual. Their occurrence in the oral cavity is rare and is difficult to distinguish from other intraoral cysts.
Method
A 27-year-old female patient presented with a swelling to the oral and maxillofacial surgery department for the removal of the cystic lesion.
Results
Based on the clinical and radiographic features the provisional diagnosis was given as odontogenic keratocyst. But the histopathological examination revealed a stratified squamous cystic epithelium with abundant keratin suggestive of an epidermoid cyst.
Conclusion
This case report presents an uncommon finding in the oral cavity with a history of teeth extraction. Based on these findings even though epidermoid cyst is rare it should be included in the differential diagnosis of radiolucent lesions of the jaws.
Explaining the Experiences of the Reasons for Non-Adherence to Treatment of Leukemia Cancer Patients in the Least Privileged Province of the Country: A Qualitative Study
Authors: Baygi Mehdi Zanganeh , Peyvand Mostafa , Bahabadii Faezeh Mirani , Noormohamadi Sayedeh Narges
Published: September 2024

Introduction: One of the most important challenges in cancer patients is the long treatment period, and as a result, non-compliance with the treatment, considering the cultural and indigenous context of Sistan and Baluchistan province, the importance of this position is felt more. Therefore, the present study was conducted with the aim of explaining the experiences of non-adherence to treatment in Leukemia cancer patients.
Methods: This cross-sectional study was conducted qualitatively with a content analysis approach via a purpose-based sampling method on 34 leukemia cancer patients with a mean age of 46±7 in 2022. The data collection tool was a semi-structured interview guide. All interviews were recorded and implemented daily on paper. Finally, the data was coded using conventional content analysis method.
Results: In this study, 17 women and 17 men were included in the study. 9 (26/5%) of them were more than 50 years old. After summarizing and coding the issues raised by the participants, 114 initial codes were obtained, five main themes (financial problems, lack of access to medical services, distrust of the health system and treatment, drug interactions and lack of motivation to continue treatment) and 10 sub-themes were extracted.
Conclusion: It can be concluded that adherence to drug regimen in cancer patients is a complex issue that depends on many factors. The financial and spiritual support of the government, increasing insurance coverage, and developing infrastructure for better access of patients to medicines and medical centers are among the implementation suggestions of this study.
Diversidade, equidade e inclusão nas organizações hospitalares e o papel do gestor: revisão de escopo
Authors: Cassiano Carolina , Oliveira Priscila Andreja , Macedo Sonia Maria Kalckmann de , Silva Iasmin Gabrielli da , Henriques Silvia Helena , Leal Laura Andrian
Published: September 2024

Objetivo: investigar as práticas de diversidade, equidade e inclusão implementadas para os trabalhadores nas organizações hospitalares, com foco no papel do gestor. Método: trata-se de uma revisão de escopo, utilizando cinco bases de dados: Base de Dados da Enfermagem; Cumulative Index to Nursing and Allied; Literatura Latino-Americana e do Caribe em Ciências da Saúde, PubMed e SCOPUS, sem restrição de idioma, no período de 2019 a fevereiro de 2024. Resultados: considerou-se 13 estudos, todos internacionais, dos quais oito artigos são oriundos dos Estados Unidos (61,53%). A partir dos estudos, três categorias foram construídas: Estratégias de Liderança e Gestão Inclusiva; Capacitação e Treinamento; e Políticas e Estruturas Organizacionais. Verificou-se uma tendência crescente nas organizações e gestores para a diversidade, equidade e inclusão dos trabalhadores hospitalares, como parte das suas práticas administrativas. Conclusão: a incorporação de estratégias educacionais até a criação de políticas sólidas possibilitam a consciência sobre o tema, com vistas a ambientes de trabalho mais justos, inclusivos, produtivos e harmônicos, que consequentemente reflete na qualidade da assistência prestada aos usuários.
Entre a cruz e a espada: dilemas na gestão de recursos humanos da atenção primária
Authors: Fontes de Carvalho Mailson , Setenta Andrade Cristina
Published: September 2024

Objetivo: investigar os desafios enfrentados na gestão de recursos humanos da atenção primária à saúde. Método: estudo descritivo, exploratório e de abordagem qualitativa, realizada em 2019. Utilizou-se entrevistas semiestruturadas com coordenadores de atenção primária de municípios do interior do Piauí. A análise temática foi realizada com auxílio do software MAXQDA. Resultados: participaram 28 gestores, e foram identificados 52 segmentos de falas, codificados em oito subcategorias, que conformaram as duas categorias temáticas: Perfil profissional desalinhado com as necessidades da atenção primária e Tensões sobre remuneração e jornada de trabalho, com destaque para o foco no dilema da flexibilização da jornada de trabalho dos profissionais, suas motivações e impactos. Conclusão: questões relacionadas ao gerenciamento de recursos humanos e em especial à remuneração e jornada de trabalho impulsionam gestores à difíceis tomadas de decisão na busca de soluções para a manutenção operacional da atenção primária, afrontando por vezes, normativas e questões éticas.
Qualidade de vida de cuidadores informais de crianças com Transtorno do Espectro Autista
Authors: Herculano Santiago Silva Ana Viviane , Silva Campos Jamylle , Homobono Machado Angélica , Monteiro de Araújo Ana Paula , Araújo Cardoso Dias Biatriz , De Oliveira Silva Dayse Danielle
Published: September 2024

Objetivo: Avaliar a qualidade de vida e a satisfação de cuidadores informais de crianças com Transtorno do Espectro Autista, e correlacionar com o comprometimento das habilidades da criança e com os fatores ambientais facilitadores e barreiras. Métodos: Foram avaliados 16 cuidadores informais de crianças atendidas no Centro Especializado de Reabilitação III. Os instrumentos de coleta de dados utilizados foram o WHOQOL-BREF, uma ficha de dados sociodemográficos, a Escala de Classificação de Autismo na Infância e os fatores ambientais da Classificação Internacional de Funcionalidade, Incapacidade e Saúde. Os resultados foram apresentados em valores absolutos e frequência e submetidos ao Teste de Correlação de Spearman. Resultados: 87,5% dos cuidadores eram do sexo feminino com idade entre 30 e 50 anos. A qualidade de vida apresentou correlação moderada com os fatores de apoio e relacionamentos de amigos (e320; p=0,032; rho 0,538) e com os fatores atitudes individuais de amigos (e420; p=0,015; rho 0,595); já a satisfação com a saúde apresentou correlação moderada com os fatores apoio e relacionamentos de amigos (e320; p=0,012; rho 0,609) e com os fatores normas, práticas e ideologias sociais (e465; p=0,040; rho 0,517). Conclusão: A qualidade de vida dos cuidadores avaliados foi impactada pelo apoio e relacionamentos de amigos e atitudes individuais de amigos. A satisfação com a qualidade de vida demonstrou relação com o apoio e relacionamentos de amigos e da variável de normas, práticas e ideologias sociais.
Primeiros socorros para profissionais da educação que atuam com crianças
Authors: De Castro Silva Emilene , Barbosa Gonçalves Laura , Teixeira Silva Aline , Oliveira Silva Pereira Vanessa , Santos Barbosa Oliveira Iácara , Goulart Alves Mateus
Published: September 2024

Objetivo: avaliar o nível de conhecimento teórico antes e após uma capacitação sobre Primeiros Socorros para profissionais que atuam com crianças nos Centros Municipais de Educação Infantil. Método: pesquisa quantitativa com delineamento quase-experimental do tipo antes e depois com profissionais dos centros de educação infantil através da capacitação intitulada: “Primeiros Socorros para profissionais que atuam com crianças”, realizada entre setembro a outubro de 2023. Utilizou-se dois instrumentos: um sobre o perfil sociodemográfico e outro com 18 questões como pré teste. Posteriormente foi realizada a capacitação teórica e prática e, após isso, a aplicação do pós-teste. Resultados: a média de idade dos profissionais foi de 42,5 anos e a maioria (76,0%) declarou participação prévia em cursos de primeiros socorros. Após a capacitação, o percentual geral de acertos foi de 97%. Conclusão: apesar da participação anterior em cursos e conhecimento insuficiente sobre atendimento de primeiros socorros no pré-teste, verifica-se um aumento substancial no conhecimento após a aplicação da capacitação no pós-teste.
Factors associated with engagement in nursing workers
Authors: Carvalho Campos Ana Paula , Campos Pavan Baptista Patrícia
Published: September 2024

Objective: to measure the engagement of nursing workers and verify the association between engagement and sociodemographic variables in these workers. Method: quantitative cross-sectional research, with nursing workers, from the Mother and Child Department, of a private and philanthropic hospital, in the city of São Paulo - SP/Brazil. Data collection took place in 2022, via the REDcapTM digital platform, with sociodemographic questions and the UWES-9 (Utrecht Work Engagement Scale). Descriptive analyzes were carried out and correlations between variables were obtained using Spearman's correlation coefficient, using the free software R version 4.2.2 for the analyses. Result: for half of the 210 respondents, all dimensions and the total scale score presented median values above 5.00, indicating high worker engagement. The variables Age and Professional category had a positive statistical association with engagement, and it was identified that nursing workers who did not have health issues in the previous month had a higher median score. Conclusion: the study showed high participant engagement, with all items scoring greater than or equal to 5.00. Engagement was positively correlated with the variables age, with greater engagement among older ages, and with the professional category, which showed the highest median score among nursing assistants and technicians, 5.33, while nurses had a median score of 5.06.
Bóg – świat – człowiek w traktatach Corpus Hermeticum na tle greckiej tradycji filozoficznej
Authors: Tylak Aneta
Published: September 2024

Hermetyzm – nurt filozoficzno-religijny, który swymi korzeniami sięga starożytności – także dzisiaj jest przedmiotem zainteresowania nie tylko w kręgach filologicznych, filozoficznych, religioznawczych, lecz przede wszystkim stanowi źródło inspiracji, a czasem wręcz uniesień duchowych czy religijnych, o czym świadczy wiele publikacji dających wykładnię pism hermetycznych w duchu przypominającym egzegezę pism świętych. Na przestrzeni wieków szeroko pojęty hermetyzm wywarł wpływ na postaci tej miary, co Leonardo da Vinci, Albrecht Durer, Sandro Botticelli, Roger Bacon, William Blake, Johannes Kepler, Mikołaj Kopernik, Isaac Newton, John Milton, Carl Gustav Jung. Jego echa możemy również odnaleźć we współczesnej literaturze.
Celem tej książki jest zapoznanie czytelnika z jednym z najważniejszych źródeł myśli hermetycznej – zbiorem greckich traktatów Corpus Hermeticum – oraz przybliżenie tak zwanej „hermetycznej triady”, na którą składają się: bóg, świat i człowiek.
„Kłopotliwe” ciała
Authors: Cybulski Adam
Published: September 2024

W ramach prężnie rozwijających się od około trzydziestu lat badań nad niepełnosprawnością (ang. disability studies) szczególnie chętnie omawiane zjawisko stanowią reprezentacje „anormalności” fizycznej obecne w mediach audiowizualnych. Jednakże w literaturze naukowej najwięcej uwagi poświęca się porządkowi fabularnemu i ogólnie pojętej zdarzeniowości przedstawionym w tekście: cechom osobowym bohatera z niepełnosprawnością, jego statusowi społecznemu, działaniom, introspekcji czy relacjom ze społeczeństwem. Problemy środków wyrazowych, rozwiązań narracyjnych oraz estetycznych aspektów ekranowej konstrukcji „anormalnego” ciała z reguły nie mieszczą się w obszarze zainteresowań badaczy. Celem publikacji jest rozwinięcie refleksji nad oferowanymi przez współczesny film fikcji obrazami fizycznej „nieprawidłowości” o analizę filmoznawczą. Autor rozprawy sięga do wybranych zagadnień z neoformalno-kognitywnej teorii filmu. Koncepcje strategii narracyjnej, dominanty diegetycznej oraz zaangażowania widza w postać pozwoliły autorowi na wskazanie przykładów wykorzystania ciała stanowiącego atrybut piętna w charakterze atrakcji wizualnej, wyodrębnienie czterech trybów opowiadania we współczesnym filmie fikcji, omówienie ich związków z długą historią portretowania „oczywistej odmienności” oraz przybliżenie sposobów zarządzania „kłopotliwymi” ciałami przez instancje narracyjne.
Część badań sﬁnansowano w ramach programu Ministra Nauki i Szkolnictwa Wyższego pod nazwą „Narodowy Program Rozwoju Humanistyki” w latach 2016–2019. Nr 0073/NPRH4/H2b/83/2016.
Comparing Typing Methods for Foot-and-Mouth Disease Virus Serotypes: Sandwich ELISA, Multiplex PCR, RT-LAMP and SYBR Green Real-time PCR
Authors: Brahma Derhasar , Sharma Krishna , Barman Nagendra N. , Deka Pankaj , Borah Biswajyoti , Buragohain Bijoy M. , Ahmed Rofique , Hazarika Ritam
Published: September 2024

Background: Foot and Mouth Disease (FMD) poses a significant economic threat to the cattle population in Assam, with recurrent outbreaks occurring annually. Methods: This study aimed to compare different diagnostic techniques for the molecular detection and serotyping of Foot and Mouth Disease Virus (FMDV) outbreaks in the region. Epithelial tissue samples (n=29) were collected following standard procedures. SYBR Green real-time PCR targeting the 3D gene, sandwich enzyme-linked immunosorbent assay (S-ELISA), multiplex PCR (mPCR), and reverse transcription loop-mediated isothermal amplification (RT-LAMP) were utilized for detection and serotyping. Results: All 29 tissue samples tested positive for FMDV using SYBR Green real-time PCR, mPCR, and RT-LAMP, with 100% congruence in serotyping (20 serotype O, 9 serotype A). In contrast, S-ELISA detected only 86.21% of samples as positive (17 serotype O, 8 serotype A). Statistical analysis revealed significant differences between the sensitivity of S-ELISA and molecular techniques (p = 2.91×10-7).The findings underscore the superior sensitivity of SYBR Green real-time PCR, mPCR, and RT-LAMP, highlighting their potential for enhancing FMDV surveillance and control efforts in Assam.
Preparation and Evaluation of Co-Delivery of Tamoxifen and Curcumin Solid Lipid Nanoparticles (Slns) on Breast Cancer Cells MCF-7
Authors: Aboutaleb Ehsan
Published: September 2024

Breast cancer is caused by the growth of a malignant tumor mass. Luminal subtypes mainly contain estrogen and progesterone receptors. Three classes of drugs can be noted for the treatment of breast cancer, one of which is the selective estrogen receptor modulator (SERMs) such as TMX. The oral bioavailability of TMX is increased in the presence of CUR. CUR can also influence the expression of oncogenic proteins involved in the breast cancer progression. SLNs have been developed as leading nanocarriers in the treatment of cancer. SLNs containing TMX and CUR were prepared by microemulsion techniques. The average size of nanoparticles was 19.46 nm. Around 99.97% of CUR and 98.7% of TMX had loaded on nanoparticles, about 78% of TMX and 80% of CUR were released. An in vitro study of antiproliferative activity, carried out on MCF-7 cell line, demonstrated that TMX-CUR SLNs showed an antitumoral activity. The results of characterization assessments and in vitro antiproliferative activity intensely support the potential application of TMX-CUR SLNs as a carrier system at extended-release useful for breast cancer treatment. TMX-CUR SLNs had a suitable size and high loading capacity and are controlled release. They have a higher efficacy than free drugs in vitro situations.
Analyzing the dynamics of import demand function in Pakistan: Long-term and short-term relationships with key economic factors
Authors: Ahmad Shakil , Maqbool Imran , Raihan Asif , Xin Liu
Published: September 2024

This study investigates the short-term and long-term correlations between total imports in Pakistan and a set of explanatory variables. We utilized the Autoregressive Distributed Lag (ARDL) model, and we estimated the import demand function for the period from 1980 to 2021. The Augmented Dickey-Fuller (ADF) test confirmed that none of the variables exhibited second-order integration, ensuring their suitability for the ARDL approach. Bounds testing indicated the existence of a long-term equilibrium relationship among the included variables. Furthermore, diagnostic tests validated our model's statistical robustness, ensuring our findings' reliability. The long-term analysis shows significant relationships between imports and key economic indicators such as gross domestic product (GDP), the inflation rate, and the import demand function. Furthermore, we found a slight positive impact on import demand from the import price index and foreign direct investment (FDI). These results emphasize the included relationships between various macroeconomic factors and import demand in Pakistan. Based on these findings, we recommend that the government implement policies aimed at boosting investment, stimulating economic growth, and controlling inflation. Specifically, policies that target enhancing foreign direct investment (FDI), maintaining stable inflation rates, and promoting economic growth will be crucial in strengthening the import demand function. These measures will not only support sustainable economic development but also optimize the import dynamics in Pakistan’s economy.
Intervención en habilidades de percepción visual y coordinación visomotora para procesos de lectoescritura en paciente secuelar de accidente cerebrovascular
Authors: Vargas Clemente William Frank , Huamán Yanac María Esther
Published: September 2024

El presente reporte describe la rehabilitación desde la terapia ocupacional de una paciente secuelar de accidente cerebrovascular. Se quiere dar a conocer el proceso de intervención en terapia ocupacional y las técnicas de terapia visual utilizadas en el entrenamiento de habilidades visoperceptuales mediante un enfoque perceptivo-cognitivo para mejorar procesos de lectura y escritura. El proceso de intervención contó con planificación, implementación y evaluación de resultados. Tras la intervención se evidencia una mejora de las habilidades visoperceptuales básicas y necesarias para la lectoescritura.
The Future of ICT Integration in Antiguan Secondary Schools: A Post-Covid Perspective
Authors: Donaldson Anthony S. , Jackman W. Marc
Published: September 2024

In this article, specific findings from a larger mixed-methods study that examined the leadership strategies Antiguan school principals employed to integrate technology into the curriculum are examined. In particular, the goal was to provide a greater understanding on some of the potential future applications of ICT integration in curriculum delivery, as identified by educators and school administrators. This study was anchored by the International Standards for Technology in Education (ISTE) model, an established technology leadership theoretical framework, as well as a technology integration framework, TPACK. Qualitative data were gathered from school principals and teachers through the use of semi-structured interviews (N=27). Furthermore, the qualitative data were manually coded and subjected to thematic content analysis. Regarding the future of ICT Integration in Antiguan Secondary Schools, several themes emerged such as, the need for increased online instruction, integrating AI technologies, as well as the acquisition of more advanced ICTs. The development of a contemporary technology use policy for secondary schools is one of the recommendations, along with pre- and in-service training for principals and educators.
Social Determinants of Health (SDoH) and Hepatitis B and C Health Inequalities Among Male Prisoners in Nigeria: A Narrative Literature Review
Authors: Onyemali Chidi Peter , Ode Damilola Kudirat , Madihi Salma
Published: September 2024

Viral hepatitis caused by hepatitis B virus (HBV) and hepatitis C virus (HCV) pose a significant global health challenge, with an increasing number of deaths and a substantial burden on healthcare systems, among prisoners in particular. Nigeria ranks fifth in Africa for prison population, with 98.2% being males and are more likely than females to have higher rates of viral hepatitis and other risky behaviours. This literature review explores the impact of social determinants of health (SDoH) on the prevalence and outcomes of HBV and HCV infections among male prison inmates in Nigeria, by examining factors such as overcrowding, inadequate healthcare access, and food insecurity. This review reports the updated data on HBV and HCV infection rates among inmates in different regions in Nigeria, with a special focus on related risk factors, highlighting how these determinants contribute to the high rates of hepatitis infections in this category. The review underscores the urgent need for a multifaceted approach involving policy changes, improved healthcare access, and enhanced preventive measures to address these health disparities. The findings aim to inform public health strategies and interventions to reduce the transmission and impact of viral hepatitis in prison settings, aligning with global health goals and promoting health equity among this population group.
Under Normoxia Simvastatin Shifts Lipid Metabolism of B16.F10 Melanoma Cells to Support Their Aggressiveness
Authors: Negrea Giorgiana Gabriela , Balacescu Loredana , Sesarman Alina , Banciu Manuela
Published: September 2024

Our previous studies demonstrated a tight connection between simvastatin (SIM) inhibition of B16.F10 murine melanoma cell proliferation in vivo and in vitro and strong suppression of the subunit α of hypoxia inducible factor 1 (HIF-1) (HIF-1 α) production in these cancer cells. Since the translation of HIF-1α is modulated by signaling pathways coordinated by Akt, SIM effects on the link between these two regulatory factors and cancer cell metabolism under normoxia was investigated, which to our knowledge have never been described before. To achieve the proposed aim, SIM effects on cell metabolism were analysed at mRNA (via RNA-seq and RT-qPCR) as well as protein level (via western blot and catalytic activity of the key enzymes) Our data suggested that SIM might orientate glucose transport and metabolism to ensure replenishment of tricarboxylic acid (TCA) cycle activity. Moreover, it seems that SIM enhanced biosynthetic role of TCA over its energy role to further support synthesis of lipid-derived signaling molecules. Thus, under normoxia SIM treatment orientated lipid metabolism to stimulate isoprenoid and prostaglandin synthesis which might favor melanoma cell survival and aggressiveness.
Leveraging Religion to Reduce Food Waste: Examining Food Waste Through the Lens of Islam and Arab Hospitality
Authors: Moufakkir Omar , Auzun Busra
Published: September 2024

Food waste is a real environmental challenge worldwide. It is a major sin in Islam; yet it is ubiquitous in Muslim society, a society where the majority of people say that Islam is critical in their life. Ingrained in moral aspects of overconsumption, a conundrum this paradox study tries to unravel is why plate waste is prevalent in the Arab Muslim society, despite the teaching of the Quran [Muslim’s holy book] and Sunna [teaching and acts of prophet Muhammad] against wanton waste. The influence of religiosity on environmental concern and intentions to reduce food waste in Islam and Christianity has been widely examined. However, our understanding of why religious people waste food remains limited. This serendipitous qualitative inquiry is the first to examine food waste from the nexus triad -food waste, hospitality, and religion, and comprehensively. Findings suggest that the conception of contemporary Arab hospitality, entrenched in Karam/generosity, and entangled with the interpretation of sin and God’s mercy, is a major contributing factor to plate waste perpetuation. The gravity of food waste warrants a new conceptualization of Arab generosity. Suggestions for plate waste prevention in this cultural context, grounded in the interviews and the Quran, are presented.
Remote Sensing Analysis of Wood Volume and Volume Increments in Pine Forest Ecosystems: Insights from Vegetation Indices
Authors: Kotlarz Jan , Kubiak Katarzyna , Kacprzak Mariusz , Oszako Tomasz
Published: September 2024

This article explores the use of vegetation indices (VIs) in remote sensing for estimating standing wood volume and volume increments in forest ecosystems. The study investigates the correlations between various VIs and wood volume across different forest stand age classes, focusing on the effectiveness of commonly used indices such as Squared Ratio Simple Red Edge (SQSR) and Red-Edge Ratio Vegetation Index (RERVI), as well as other typical indicators including Enhanced Vegetation Index (EVI), Red-Edge EVI (RE-EVI), and Green Normalized Difference Vegetation Index (GNDVI). Additionally, the analysis considers a pair of indicators based on blue and near-infrared channels, resembling the Blue-normalized Difference Vegetation Index (BNDVI). The research reveals that quadratic and power-law models of SQSR and RERVI demonstrate higher correlations (>0.40) with wood volume, especially in younger forest stands (>0.80). Furthermore, the study highlights the potential of NDII and NDWI indices for estimating volume increments in certain classes of forest stands (0.70). However, correlations vary across different forest stand classes, suggesting the need for further investigation into the reliability of VIs for monitoring wood volume and volume increments in forest ecosystems. Overall, this research contributes to the understanding of the applicability of VIs in remote sensing for forest management and ecosystem monitoring.
On a Unitary Solution for the Schrödinger Equation
Authors: Mulian Achimeir Yair
Published: September 2024

For almost 75 years, the general solution for the Schrödinger equation was assumed
to be generated by an exponential or a time-ordered exponential known as the Dyson
series. We study the unitarity of this solution in case of singular Hamiltonian and provide a
new methodology that is not based on the assumption that the underlying space is L2(R).
Then, an alternative operator for generating the time evolution is suggested that is manifestly
unitary, regardless of the choice of the Hamiltonian. The new construction involves an additional
positive operator that normalizes the wave-function locally and allows us to preserve
unitary even on indefinite norm spaces. Our considerations show that Schrödinger's and Liouville's
equations are, in fact, two sides of the same coin, and together they become the unified
description of quantum systems.
Validation of sample extraction and analysis techniques for simultaneous determination of legacy and insensitive munitions (IM) constituents
Authors: Scircle Austin , Crouch Rebecca , Smith Jared , Kimble Ashley , Stromer Bobbi , Beal Samuel , Clausen Jay , Georgian Thomas , Bednar Anthony
Published: September 2024

Currently, no standardized method exists for the analysis of insensitive munitions (IM) in environmental matrices such as water, soils, and tis-sues. However, standardized methods, such as United States Environmental Protection Agency (EPA) 8330B, exist for legacy munitions for water and soil matrices. The lack of standardized methods for IM analysis leads researchers to use a wide variety of incomplete and overlapping analytical methodologies. The overall project’s first phase, Strategic Environmental Research and Development Program (SERDP) Environmental Restoration (ER)–2722, was to develop and optimize methods to address these methodological gaps by creating analytical methods for simultaneous analysis of IM and legacy munitions in water, soil, and tissue matrices. The main objective of the current project phase, Environmental Security Technology Certification Program (ESTCP) ER19-5078, is to build upon the previous work in phase one and to focus on the validation of the newly developed methods. Synergizing with the main objective of the overall project, the methods were validated and submitted to the EPA for inclusion as a possible addendum to EPA 8330B.
Transdisciplinary employability practitioners: Engaging with skills for the future and redefining professional identity
Authors: Buck Adrian
Published: September 2024

In response to the need for graduates to tackle global, complex problems, higher education is increasing attention towards approaches that cross the boundaries of disciplinary thinking. However, while students can benefit from learning across disciplines, employability practitioners can also benefit. Transdisciplinary approaches can prompt practitioners to rethink career education, take charge of their professional development, and redefine their identity as borderless, ever-evolving transdisciplinary employability practitioners. Within this provocation, a transdisciplinary approach to learning is introduced and questions pertinent to the seven habits of a transdisciplinary mind are posed, intended to provoke converging perspectives on employability. By refocusing practitioners’ employability perspectives, higher education can enhance its capacity for career-led learning and transform the identities of those working within it.
Creating group work-integrated learning experiences for non-clinical health degrees: A practitioner reflection
Authors: Colson Natalie , Maddock Louise , Shuker Mary-Ann , Georgina Sanger
Published: September 2024

Work-Integrated Learning (WIL) experiences, integral for equipping students with the skills and knowledge crucial for employment and success in their chosen careers, have traditionally been associated with accreditation requirements in professional programs. More recently, acknowledging the importance of WIL experiences in non-professional programs has grown. In this reflective paper, the experiences of the practitioner tasked with developing a new WIL capstone course for students in Health and Biomedical Science degrees are described. Grounded in social exchange theory, where interactions are viewed as exchanges aimed at maximising rewards while minimising costs, the intent was for student groups to engage with a range of authentic project experiences offered by industry, community, and academic staff (the WIL partners). Critical elements were the active involvement of a diverse array of partners and the importance of relationship building for the long-term sustainability of the project experiences. I discuss and reflect on the specific strategies employed to engage the WIL partners, inspiring them to collaborate and develop meaningful projects suitable for students pursuing various career paths. Additionally, I reflect on the invaluable experiences and feedback provided by our partners.
Using image-reflections to support undergraduate students’ relational employability: A practitioner reflection
Authors: Wallace Ruth , Doherty Sally-Anne , Cook Elizabeth J.
Published: September 2024

This practitioner reflection explores our integration of the Relational Employability Framework within the Health Research Project capstone unit of a Bachelor of Health Science degree. To address the historically low quality of student reflections, we incorporated image-based reflective activities to improve engagement and depth. These activities encouraged students to use visual media to examine their developing relational employability. We developed and implemented a series of tutorial activities designed to scaffold this process, aiming to foster deeper reflective practice and highlight its importance for career development and employability. Our reflections indicate that, while grades did not significantly increase, students showed enhanced critical thinking and engagement with reflective practice, suggesting the framework’s effectiveness in broadening awareness and enriching employability overall. We discuss the need for peer support among educators to sustain and enhance reflective practices in teaching-learning and conclude with thoughts on our ongoing efforts to embed and expand reflective practices in teaching approaches
Bridging the gap: Graduate dispositional employability and the interconnected relationship between third space career and learning support services
Authors: Luke Jennifer , Bartlett Cristy
Published: September 2024

This conceptual paper explores the dynamic interplay between university career development and learning support services. A distinct focus on enhancing dispositional employability of both staff and the graduates they support is discussed. Integral to successful career preparedness, the essential attributes of dispositional employability include openness to work change; resilience via a sense of control over career decision-making; an optimistic and proactive approach to seeking future opportunities; motivation in career self-management, and confidence in linking work and personal identity. Additionally, the paper also discusses how career and learning support services are positioned within the third space of higher education which is outside of administrative and traditional academic spaces. The significance of collaborating whilst maintaining distinct career development and learning advisory services is highlighted, so as to enhance graduate employability via effective connection of academic learning with career readiness. Investigations of the literature in the field lead to a conceptual model, the Maturity Model of Integrated Career and Learning Services (MM-ICLS), and recommendations that encourage collaborative peer support and capacity building for these third space staff, and congruent student support that will strengthen the dispositional employability of graduates and empower student success.
Asymptomatic Migration of Ureteral Stent to Superior Vena Cava After Ultrasound-Guided Percutaneous Nephrolithotomy: An Extremely Rare Case and Review of the Literature
Authors: Hassani Amir Hossein , Kamran Hooman , Kojuri Javad , Bazroodi Helia , Fatemian Hossein , Rasekhi Alireza , Naderi Nima , Kooshafar Saeed , Dehghani Anahita , Haghpanah Abdolreza
Published: September 2024

Ureteral stent migration should be considered a rare complication of urologic procedures. We report a 69-year-old lady diagnosed with ureteral stent migration two weeks after undergoing percutaneous nephrolithotomy while she was symptom-free. The stent passed the heart and extended to the superior vena cava and right brachiocephalic vein. After excluding thrombus formation, the stent was retrieved with endovascular approach. Stent migration to superior vena cava while being asymptomatic is extremely rare. Considering this complication is crucial to prevent consequent fatal events. This case highlights this rare complication of ureteral stent placement and reviews its management.
Characterization of language abilities and semantic networks in very preterm children at school-age
Authors: Décaillet Marion , Christensen Alexander P. , Besuchet Laureline , Huguenin-Virchaux Cléo , Fumeaux Céline J. Fischer , Denervaud Solange , Schneider Juliane
Published: September 2024

It has been widely assessed that very preterm children (<32 weeks gestational age) present language and memory impairments compared to full-term children. However, differences in their underlying semantic memory structure have not been studied yet. Nevertheless, the way concepts are learned and organized across development relates to children’s capacities in retrieving and using information later. Therefore, the semantic memory organization could underlie several cognitive deficits existing in very preterm children. Computational mathematical models offer the possibility to characterize semantic networks through three coefficients calculated on spoken language: average shortest path length (i.e., distance between concepts), clustering (i.e., local interconnectivity), and modularity (i.e., vocabulary enrichment). Here we assessed these coefficients in 38 very preterm schoolchildren (aged 8-10 years) compared to 38 full-term schoolchildren (aged 7-10 years) based on a verbal fluency task. Using semantic network analysis, very preterm children showed a longer distance between concepts and a lower interconnectivity at a local level than full-term children. However, we found no differences between very preterm and full-term children regarding their modularity at a global level. These findings provide preliminary evidence that very preterm children demonstrate subtle impairments in the organization of their semantic network, encouraging the adaptation of the support and education they receive.
Dynamic optimization elucidates higher-level pathogenicity strategies of Pseudomonas aeruginosa
Authors: Dimitriew Wassili , Schuster Stefan
Published: September 2024

Pseudomonas aeruginosa is a robust pathogen and possesses many virulence components, including the ability to survive inside macrophages. A minimal model is proposed to study the interaction of P. aeruginosa and the human host in terms of nested defence, in which the host and pathogen counter each other in a back-and-forth interaction. In particular, the pathogen attacks the host, macrophages of the host engulf the pathogen and reduce its access to glucose, the pathogen activates the glyoxylate shunt which is started by an enzyme isocitrate lyase (Icl), the host inhibits it by itaconic acid, and the pathogen metabolizes itaconic acid using the enzyme succinyl-CoA:itaconate CoA transferase (Ict). Therefore, the pathogen needs to allocate its limited protein resource between the enzymes Icl and Ict in order to maximize the time integral of a flux through the enzyme Icl. We use both random search and dynamic optimization and analyze three different scenarios of the interaction. We identify the enzyme Ict as a cost-effective means of counter-counter-counter defence and as a possible drug target.
Sexual reproduction and physiology of the soft coral Sclerophytum eilatenis along depth
Authors: liberman Ronen , Benayahu Yehuda , Tamir Shay
Published: September 2024

The ability of species to thrive across environmental gradients relies on their ability for sexual reproduction and physiological adaptations to varying conditions. Advances in diving technologies have enabled in-depth research into corals ecology and biology along depth gradients, from shallow-water habitats to mesophotic coral ecosystems (MCEs; 30-150 m). Findings from such studies suggest that MCEs may act as refugia for some species, providing shelter from threats such as global climate change and local stressors. However, effective refugia necessitate that individuals within a population can both reproduce sexually and adapt physiologically along their depth range. This study investigates the reproductive biology and physiological traits of the zooxanthellate octocoral Sclerophytum eilatenis along a depth gradient in the Gulf of Aqaba/Eilat. By examining sexual reproduction characteristics and the physiological parameters of both host and symbiont, this study provides a comprehensive view into this octocoral’s adaptive nature. The current study’s findings indicate that MCEs may serve as reproductive refugia for S. eilatenis, offering favorable conditions for sexual reproduction. However, significant variations in reproductive and physiological characteristics along depth underscore the necessity for careful evaluation of the potential for MCEs to assist in the recovery of shallow reef populations. This study highlights the importance of integrating reproduction and physiological data in order to advance our understanding of coral adaptation and resilience in dynamic marine environments.
Serum Extracellular Vesicles Reveal Metabolic Responses to Time-Restricted Feeding in High Fat Diet-Induced Obesity in Male Mice
Authors: Chen Xiaoli , Bushman Theresa , Lin Te-Yueh , Fu Qin , Zhang Sheng
Published: September 2024

Objective
Extracellular vesicle (EV) secretion and cargo composition are dysregulated in metabolic diseases. This study aimed to identify changes in the EV size profile and protein cargoes in diet-induced obesity following time-restricted feeding (TRF) and to establish the role of EVs in obesity-related metabolic responses.
Methods
Mice were fed a high-fat diet (HFD) for 18 weeks prior to being placed either ad libitum or a time-restricted feeding for an additional 10 weeks. Mice on a normal chow ad libitum served as the control. The TRF group had food available for 10 hours and fasted for 14 hours per day.
Results
The serum EV size profile and amount displayed sex- and age-dependent changes in HFD-induced obesity, with age reducing EV amounts. HFD decreased small EV populations and increased larger EV populations, while TRF reversed these changes. Quantitative proteomic analysis showed that the abundance and composition of EV proteins changed in response to both acute stimulation with lipopolysaccharides (LPS) and HFD. Gene ontology analysis identified specific sets of EV proteins and their involved biological processes, reflecting the effect of LPS and HFD, as well as the reversal effect of TRF on metabolic and inflammatory pathways. EV proteins altered by HFD and those reversed by TRF had low protein overlap but significant functional overlap in biological processes. TRF activated the PPAR signaling pathway and the AKT-mTOR signaling pathway. The most significant impacts of HFD and TRF were observed on lipoprotein and carbohydrate metabolism, complement system, and neutrophil degranulation. The reversal effect of TRF on the complement system was pathway-specific, significantly activating the lectin complement pathway and restoring neutrophil degranulation.
Conclusion
Our data indicate that EVs are involved in diet-induced metabolic and inflammatory responses. Different EV populations may carry distinct sets of proteins involved in specific biological processes, thereby regulating diverse metabolic pathways efficiently.
Association between stress hyperglycemia ratio and No-reflow phenomenon in AMI patients undergoing primary percutaneous coronary intervention
Authors: Wu Peng , Wang Mohan , Ma Juan , Zhu Baozhen , Jia Shaobin , Ma Xueping , Yan Ning
Published: September 2024

The relationship between the stress hyperglycemia ratio (SHR) and no-reflow phenomenon (NRP) in acute myocardial infarction (AMI) patients undergoing primary percutaneous coronary intervention (PPCI) remains unclear. This study aimed to investigate the association between baseline SHR and NRP in AMI patients undergoing PPCI and to further explore whether neutrophils play a mediating role. The study enrolled 2725 patients with AMI after PPCI from the General Hospital of Ningxia Medical University. Patients were divided into tertiles according to the NRP and SHR levels. The characteristics of baseline data of each group were recorded. A multivariate logistic regression model was developed to analyze the association between SHR and neutrophils with NRP. The linear association between baseline SHR and NRP was explored using smooth curve fitting. Correlation analysis was employed to evaluate the relationship between SHR, NRP, and neutrophils. Mediation analysis was conducted to determine whether the association between SHR and the NRP was mediated by neutrophils and to quantify the extent of this mediation. After controlling for confounding factors, the multivariate logistic regression model showed that SHR was an independent risk factor for the NRP (OR = 3.133, 95% CI: 1.700 - 5.548, P=0.0001), and neutrophils was also an independent risk factor for the NRP (OR = 1.113, 95% CI: 1.049 – 1.180, P=0.0003). Additionally, as the SHR and neutrophils quartiles increased, the incidence of NRP also gradually increased, with a significant P-trend (P -trend < 0.05). Smooth curve fitting and subgroup analysis were used to investigate the linear relationship between baseline SHR and NRP. The correlation relationship results showed that SHR was positively correlated with NRP (r=0.122, p <0.0001) and neutrophils (r=0.187, p <0.0001). Neutrophils was positively correlated with NRP (r=0.068, P=0.0004). The mediating effect analysis showed that SHR played a partial mediating role in NRP [indirect effect :0.0028(0.0006-0.0052), P=0.010], accounting for 9.03% of the total effect. Neutrophils plays a mediating role in the effects of SHR and NRP. The SHR was independently associated with no reflow phenomenon, and neutrophils play a mediating role. The SHR can be used to assess the risk of AMI patients undergoing PPCI.
Staphylococcus aureus thermonuclease NucA is a key virulence factor in septic arthritis
Authors: Götz Friedrich , Li Ningna , Deshmukh Meghshree , Sahin Filiz , Hafza Nourhane , Ammanath Aparna , Ehnert Sabrina , Nussler Andreas K. , Weber Alexander , Jin Tao
Published: September 2024

Septic arthritis, primarily caused by Staphylococcus aureus, poses a significant risk of both mortality and morbidity due to its aggressive nature. The nuc1-encoded thermonuclease NucA of S. aureus degrades extracellular DNA/RNA, allowing the pathogen to escape neutrophil extracellular traps (NETs) and maintain the infection unabated. Here we show that in the mouse model for hematogenous septic arthritis the Δnuc1 mutant was much less pathogenic and the severity of clinical septic arthritis was markedly reduced, including decreased weight loss, lower kidney bacterial loads and much less IL-6 production. In vitro, S. aureus genomic DNA induced in macrophages a robust TNF-α response which was abrogated when the DNA was degraded by NucA. NucA induced higher IL-6 production in SAOS-2 and higher TNF-α and IL-10 production in neutrophils and shielded S. aureus from phagocyte engulfment and killing. NucA exacerbates septic arthritis possibly by increased internalization by host cells and killing of neutrophiles.