bluuebunny/crossref_metadata_2025 huggingface dataset:
The Spectral Properties of Pitted Impact Deposits on Vesta as Seen by the Dawn VIR Instrument
Authors: Michalik T. , Stephan K. , Cloutis E. A. , Matz K.-D. , Jaumann R. , Raponi A. , Otto K. A.
Published: August 2022

Pitted impact deposits (PIDs) on Vesta have been shown to exhibit distinct spectral characteristics with respect to their surrounding host deposits and other typical Vestan areas regarding the first major pyroxene absorption near 0.9 μm. The PIDs, especially those in the ejecta blanket of the large crater Marcia, show higher reflectance and pyroxene band strength with respect to their impact deposit surroundings. This study complements the spectral characterization of the PIDs on Vesta with Visible and Infrared Spectrometer observations obtained by NASA’s Dawn mission. In particular, we focus on the second major pyroxene absorption near 1.9 μm. We analyze nine PIDs in the ejecta blanket of the crater Marcia, as well as PIDs within the crater-fill deposits of the craters Marcia, Cornelia, and Licinia. We find that the second pyroxene absorption behaves in similar ways as the first major pyroxene absorption. The PIDs in Marcia’s ejecta blanket show higher reflectance and pyroxene band strength with respect to their immediate impact deposit surroundings. The PIDs present in the crater-fill deposits of Marcia, Cornelia, and Licinia, however, do not show such spectral characteristics. This is also consistent with previous observations of the first pyroxene absorption band. Based on the experimental results of other studies, we speculate that the observed spectral distinctness arises from an oxidation process in the interior of impact deposits, where Fe cations migrate within their host pyroxene grains. Thus, the surfaces of (melt-bearing) impact deposits might be different from their interiors, apart from space-weathering effects.
From Raw Data to Data Standards through Quality Assessment and Semantic Annotation
Authors: Sananikone Julien , Arnaud Elie , Norvez Olivier , Pamerlon Sophie , Archambeau Anne-Sophie , Le Bras Yvan
Published: August 2022

Data quality and documentation are at the core of the FAIR (Findable, Accessible, Interoperable, Reusable) principles (Wilkinson et al. 2016). Regarding biodiversity and more broadly ecology domains, complementary solutions of the well-known data standard (notably through Darwin Core (Wieczorek et al. 2012)) orientation are emerging from the intensive use of EML (Ecological Metadata Language (Michener et al. 1997)) metadata standard. These notably capitalize on using:

semantic annotation from EML metadata documents that describe data attributes, and

FAIR quality assessment as proposed by DataOne (Data Observation Network for Earth) network.

semantic annotation from EML metadata documents that describe data attributes, and

FAIR quality assessment as proposed by DataOne (Data Observation Network for Earth) network.

Here we propose to present this point of view by orchestrating the production of rich (with attributes description and links with terminological resources terms) EML metadata from raw datafiles and, through the generation of FAIR metrics for direct assessment of FAIRness and creation of data standards like Darwin Core. Using EML, we can describe each data attribute (e.g., name, type, unit) and associate each attribute one to several terms coming from terminological resources. Using the Darwin Core vocabulary as a terminological resource, we can thus associate, on the metadata file, original attributes terms to corresponding Darwin Core ones. Then, the data and their metadata files can be processed in order to automatically create the necessary files for a Darwin Core Archive. By acting at the metadata level, associated with accessible raw data files, we can associate raw attribute names to standardized ones, and then, potentially create data standards.
Taxonomic review of the subgenus Tatsipolia Benedek, Behounek, Floriani & Saldaitis of the genus Dasypolia Guenée with descriptions of two new species from southern Xizang, China (Insecta, Lepidoptera, Noctuidae)
Authors: Chen Enyong , Pan Zhaohui , Volynkin Anton V. , Saldaitis Aidas , Benedek Balázs
Published: August 2022

The subgenus Tatsipolia Benedek, Behounek, Floriani & Saldaitis, 2011 of the genus Dasypolia Guenée, 1852 is reviewed. Two new species, D. (T.) sejilaensissp. nov. and D. (T.) cerritulasp. nov. are described from the Linzhi (Nyingchi) Prefecture in southern Xizang, China. The adults and the male and female genitalia of all species in the subgenus are illustrated. Additionally, Dasypolia (Auropolia) carlotta Floriani, Benedek, Behounek & Saldaitis, 2011 is reported from Xizang for the first time.
Les conflits, freins et leviers pour l’ancrage territorial des aires marines protégées : une analyse comparative internationale
Authors: Cadoret Anne , Beuret Jean-Eudes
Published: August 2022

La création d’Aires Marines Protégées (AMP) fait l’objet d’oppositions qui constituent un enjeu pour leur pérennité et leur efficacité. L’article s’appuie sur l’analyse transversale de treize AMP, situées sur cinq continents, et révèle l’importance des conflits dans le processus d’ancrage territorial des AMP. Basée sur une analyse documentaire, l’observation in situ , des entretiens auprès des parties prenantes (201 au total) et la participation à des temps forts de concertation, l’analyse comparative a permis de constater l’omniprésence de conflits aux différentes étapes de l’institutionnalisation des AMP, puis de les catégoriser. Il ressort que la grande majorité des conflits ne confronte pas les promoteurs de l’AMP à des opposants à la conservation : la protection de l’environnement rassemble, c’est son mode de gestion qui divise. Bien que les contextes socio-culturels soient divers, et que les statuts, taille et type d’AMP soient différents, des facteurs récurrents renforçant les conflits ont été identifiés. Après les avoir décrits, nous nous intéressons en particulier aux plus discrets d’entre eux, traduisant l’insuffisante prise en compte des territorialités dans l’institutionnalisation de l’AMP, affectant l’acceptation du dispositif par les acteurs locaux. Mais l’article présente aussi, à partir d’exemples, les leviers d’innovations qui sont ou peuvent être activés dès lors que les conflits sont apprivoisés.
Espaces et pratiques du « chez-soi » en contexte de migration de retraite à l’international : l’exemple des Français au Maroc
Authors: Pinel Jordan
Published: August 2022

À partir d’une enquête de terrain effectuée dans le Souss-Massa (Maroc) auprès de 45 ménages retraités français, cet article questionne l’inscription dans un nouveau lieu de vie à la retraite et en migration. À partir d’une analyse des pratiques centrées autour de l’espace domestique, l’article propose une définition du « chez-soi » en migration de retraite à l’international, qui intègre à la fois les éléments matériels du logement et les pratiques immatérielles qui contribuent à recréer un sentiment de familiarité à l’étranger. L’étude de cas des retraités français au Maroc permet de mettre en avant des éléments constitutifs de la redéfinition de ce « chez-soi » et sa pratique : les lieux de vie et modes d’habiter qui dépendent de réseaux et d’infrastructures inhérents à l’espace migratoire ; la présence d’un entre-soi rassurant et familier ; la prise en compte de la famille dans les choix résidentiels ; une bi-résidence avec un logement en France qui s’inscrit dans un espace relationnel constituant l’espace migratoire de la retraite.
« Le truc du SIDA » : de la chose à l’objet, des récits socio-culturels aux récits du soi
Authors: Valverde-Rivera Florence , Teyssier Julien , Denoux Patrick
Published: August 2022

Une rupture existentielle ou une confrontation brutale à un événement traumatisant peuvent conduire la personne qui la subit à la mise en œuvre d’un remaniement psychique d’urgence. La psychologie interculturelle s’est beaucoup intéressée à ces dynamiques, qui peuvent parfois prendre une forme extrême, parfois surprenante (Teyssier, Denoux, 2013a). Au fil du temps, le dépassement de la césure sera intégré comme une partie du soi, un élément fondateur de la personnalité. Nous comprenons cette création d’un sens nouveau comme résultant du tissage des récits du soi aux récits socio-culturels (Teyssier, Denoux, 2019). Cet article exemplifie cette théorie en s’appuyant sur l’analyse du suivi psychothérapeutique de Marie-France, qui a gardé pendant vingt ans le secret de sa séropositivité. Aujourd’hui, ce secret n’a plus de raison d’être et Marie-France est mobilisée par des questionnements existentiels. L’interculturation narrative du soi, à la fois exploratrice, non-jugeante et prodigue en potentialités thérapeutiques se révèle être une piste intéressante contre la perte de sens éprouvée.
Du milieu à l’ambiance. Réflexions philosophiques sur une autre conception de l’environnement
Authors: Bégout Bruce
Published: August 2022

Notre article reprend la distinction du milieu et de l’ambiance qu’avait étudiée en son temps Leo Spitzer. Il vise à accentuer la différence entre une conception objectiviste de l’environnement et une conception qui laisse place à la résonance affective de ce qui nous entoure. L’ambiance est un milieu rendu sensible par sa présence affective et influente. Pour ce faire, notre travail questionne le concept de « médiance » d’Augustin Berque qui prétend réformer le concept trop physicaliste et déterministe de milieu et en montre néanmoins les limites, en plaidant pour une médialité ambiancielle qui se serait définitivement détachée des références à la structure sujet-objet et à l’idée d’un conditionnement psycho-physique du milieu.
Identify the characteristic in the evolution of the causality between the gold and dollar
Authors: Wang Ping , Gu Changgui , Yang Huijiu , Wang Haiying
Published: August 2022

The causal inference method based on the time-series analysis has been subject to intense scrutiny, by which the interaction has been revealed between gold and the dollar. The positive or negative causality between them has been captured by the existing methods. However, the dynamic interactions are time-varying rather than immutable, i.e., the evolution of the causality between gold and the dollar is likely to be covered by the statistical process. In this article, a method which combines the pattern causality and the state-transition network is developed to identify the characteristics of the causality evolution between gold and the dollar. Based on this method, we can identify not only the causality intensity but also the causality type, including the types of positive causality, negative causality and the third causality (dark causality). Furthermore, the patterns of the causalities for the segments of the bivariate time series are transformed to a state-transition network from which the characteristics in the evolution of the causality have also been identified. The results show that the causality has some prominent motifs over time, that are the states of negative causality. More interestingly, the states that act as a bridge in the transition between states are also negative causality. Therefore, our findings provide a new perspective to explain the relatively stable negative causality between gold and the dollar from the evolution of causality. It can also help market participants understand and monitor the dynamic process of causality between gold and the dollar.
Almost sure convergence theorems for arrays under sub-linear expectations
Authors: Wang Li , Wu Qunying
Published: August 2022

In this work, inspired by the extended negatively dependent arrays, we want to obtain a limit theorem on almost sure convergence relying on non-additive probabilities. Meanwhile, we offer two appropriate upper integration conditions as an application, allowing us to derive deterministic bounds based on logarithm. Furthermore, these results extend the limit theorems in classical probability space.
Some specific classes of permutation polynomials over $ {\textbf{F}}_{q^3} $
Authors: Qin Xiaoer , Yan Li
Published: August 2022

Constructing permutation polynomials is a hot topic in finite fields. Recently, huge kinds of permutation polynomials over $ {\bf F}_{q^2} $ have been studied. In this paper, by using AGW criterion and piecewise method, we construct several classes of permutation polynomials over $ {\bf F}_{q^3} $ of the forms similar to $ (x^{q^2}+x^q+x+\delta)^{\frac{q^{3}-1}{d}+1}+L(x) $, for $ d = 2, 3, 4, 6, $ where $ L(x) $ is a linearized polynomial over $ {\bf F}_{q} $.
On the Blaschke approach of Bertrand offsets of spacelike ruled surfaces
Authors: Aldossary Maryam T. , Abdel-Baky Rashad A.
Published: August 2022

In this paper using the Blaschke approach we generalized the Bertrand curves to spacelike ruled and developable surfaces. It is proved that, every spacelike ruled surface have a Bertrand offset if and only if an equation should be fulfilled among their dual integral invariants. Consequently, some new relationships and theorems for the developability of the Bertrand offsets of spacelike ruled surfaces are outlined.
Numerical groundwater modelling for studying surface water-groundwater interaction and impact of reduced draft on groundwater resources in central Ganga basin
Authors: Kumar Sumant , Dwivedi Anuj Kumar , Ojha Chandra Shekhar Prasad , Kumar Vinod , Pant Apourv , Mishra P. K. , Patidar Nitesh , Singh Surjeet , Sarkar Archana , Janardhanan Sreekanth , Kumar C. P. , Mainuddin Mohammed
Published: August 2022

Water resources in India's Indo-Gangetic plains are over-exploited and vulnerable to impacts of climate change. The unequal spatial and temporal variation of meteorological, hydrological and hydrogeological parameters has created additional challenges for field engineers and policy planners. The groundwater and surface water are extensively utilized in the middle Gangetic plain for agriculture. The primary purpose of this study is to understand the discharge and recharge processes of groundwater system using trend analysis, and surface water and groundwater interaction using groundwater modelling. A comprehensive hydrological, and hydrogeological data analysis was carried out and a numerical groundwater model was developed for Bhojpur district, Bihar, India covering 2395 km2 geographical area, located in central Ganga basin. The groundwater level data analyses for the year 2018 revealed that depth to water level varies from 3.0 to 9.0 meter below ground level (m bgl) in the study area. The M-K test showed no significant declining trend in the groundwater level in the study area. The groundwater modelling results revealed that groundwater head is higher in the southern part of the district and the groundwater flow direction is from south-west to north-east. The groundwater head fluctuation between the monsoon and the summer seasons was observed to be 2 m, it is also witnessed that groundwater is contributing more to rivers in the monsoon season in comparison with other seasons. Impact of reduction in pumping on groundwater heads was also investigated, considering a 10% reduction in groundwater withdrawal. The results indicated an overall head rise of 2 m in the southern part and 0.2–0.5 m in the middle and northern part of the district.
Use and Attitudes of Complementary and Alternative Medicines Among Allied Health Sciences Students, University of Peradeniya
Authors: Dayarathana Kavindi , Sakeena M.H.F. , Bowatte Gayan
Published: August 2022

Background: Complementary and Alternative Medicine (CAM) consists of a group of medical and health care systems, practices, and products delivered outside the mainstream health care system. CAM treatments can be used not only to treat diseases but also to promote wellness, disease prevention, and manage symptoms. However, someone’s attitudes toward health may contribute to seeking CAM treatments. This study aimed to investigate the use and attitudes of CAM among Allied Health Sciences (AHS) students at the University of Peradeniya.Methods: An online questionnaire was used and all AHS students at the University of Peradeniya were invited to participate. The questionnaire comprised three parts: Part A) demographic data, Part B) usage of complementary and alternative medicines and Part C) attitudes toward complementary and alternative medicines. CAM usage and attitude differences between different degree programs and academic years were compared.Results: Of the 601 students invited, 314 (52.2%) responded to the questionnaire. Among them, 143 participants (45.5%) had used CAM during the past 12 months. Of them, vitamins were the most used CAM. Most participants (70.1%) had used CAM to improve their health, while (68.5%) had selected CAM to reduce side effects. More than one-third of students showed positive attitudes towards CAM. There were significant differences in CAM usage between students of pharmacy/nursing and MLS/Radiography/Physiotherapy, while there was no difference in attitudes regarding CAM. There were differences in attitudes concerning CAM between senior and junior students, however no difference in CAM usage.Conclusion: This study found that AHS students commonly reported using CAM. A comparison between Pharmacy/Nursing and MLS/Radiography/Physiotherapy students suggests that pharmacy/nursing education is associated with improved awareness and use of CAM among AHS undergraduate students in a Sri Lankan university.
Development of an Optimal Short Course for Pharmacy Students in Sri Lanka to Enhance the Knowledge of Antimicrobial Resistance
Authors: Sakeena M.H.F. , Bennett Alexandra A. , McLachlan Andrew J.
Published: August 2022

Antimicrobial resistance (AMR) has been identified as one of the greatest threats to human health. Healthcare professionals play a pivotal role in patient care activities, and an understanding of antimicrobial agents and AMR is a critical component of high-quality care. Pharmacists are experts in medicines, and their education and training can directly impact the quality of services they provide to patients. Antimicrobial stewardship (AMS) competencies for pharmacy students have been developed and implemented in the developed world. However, in developing countries like Sri Lanka, there is a gap in the training of pharmacy students in AMS competencies, thereby hindering their ability to be effective in stewardship activities upon graduation.This study presents a protocol that includes learning outcomes and content to explore a national consensus on AMS competencies that will improve knowledge about antibiotics and AMR in pharmacy students in Sri Lanka. The first draft of the proposed curriculum was developed through a literature review, informed by extensive investigations of pharmacy students’ current knowledge and understanding and ensuring suitability in the Sri Lankan context. A process of liaising with academics and stakeholders in Sri Lanka and discussions with academics from developed countries (such as Australia) was used to prepare the final draft. Future consultation and implementation will also seek further input from current and recently graduated pharmacy students in Sri Lanka. The competencies developed will apply to pharmacy undergraduate programs in Sri Lankan universities and for practicing Sri Lankan pharmacists in a continuous professional development program. Once implemented, this protocol will help strengthen AMS education amongst pharmacists in Sri Lanka and ultimately benefit Sri Lankan consumers and assist other health care professionals addressing AMR.
Antibacterial Activity of Honey in Combination with Cinnamon
Authors: Dalugodage Sachira S. , Tennakoon Imalka
Published: August 2022

Emergence of antimicrobial resistance (AMR) is a major global concern today. High prevalence of multidrug resistant (MDR) bacteria cause the treatments to be less effective or ineffective and finally leads to higher rates of mortality. This situation urges the development of novel antimicrobial agents. Natural products have gained more attention as safe and cost-effective sources of candidate compounds. Honey possesses a potent antibacterial activity against a wide range of bacteria. High osmolarity, acidic pH, hydrogen peroxide production, and presence of nonperoxide compounds provide various mechanisms for honey to act against bacteria. Cinnamon also has the ability to act on a number of bacteria through destruction of cell membranes, anti-quorum sensing effect, ATPase inhibition and membrane porins inhibition. Thus, the combinations of honey and cinnamon have shown important interactions such as synergistic, additive and antagonistic effects due to the interactions among various constituents in them. Their combined action varies depending on the honey type, cinnamon plant species, cinnamon extract type, etc. Therefore, both honey and cinnamon can be considered as good candidates for developing new antimicrobial agents. Further studies are required to isolate and identify bioactive compounds and to clarify their exact mechanisms of action, antibacterial spectrum, and toxicities.
Polymorphic eruption of pregnancy: A case report
Authors: Zejnullahu Vjosa A. , Zejnullahu Valon A.
Published: August 2022

Polymorphic eruption of pregnancy (PEP) is a benign self-limiting dermatosis that occurs during pregnancy and/or postpartum period. Etiology is unknown and evidence suggest a relationship between excessive maternal weight gain, cesarean deliveries, skin overdistension, multiple gestation and male fetuses. We present a case of polymorphic eruption of pregnancy in a 26-year-old woman with twin pregnancy. We recommend prompt evaluation and diagnosis of a pregnant woman with primary skin lesions and pruritus to differentiate between the benign polymorphic eruption of pregnancy and other dermatosis which are associated with increased fetal morbidity.
The influence of policies limiting author self-citations on journals impact factor and self-citation rate in respiratory system
Authors: Sanfilippo Filippo , Crimi Claudia , Morgana Alberto , La Via Luigi , Astuto Marinella
Published: August 2022

To assess the presence of journal policies discouraging inappropriate author’s self-citation (A-SC) in “Respiratory System” journals, we evaluated submission guidelines of “Respiratory System” journals included in Journal-Citation Reports 2020 (Clarivate Analytics®) for presence of policies on A-SC and its impact on journals’ self-citation (J-SC) rate and impact factor (IF). We found that 14.3% of journals (n=8/56) reported policies on inappropriate A-SC. The median IF was not different in “Respiratory System” journals with (3.6; IQR:2.3) vs without A-SC policies (3.1; IQR:3.0; p=0.41). The J-SC rate was not influenced by presence of A-SC policies (p=0.83). Fully open-access (n=14) and traditional (n=42) journals had no differences in IF (3.3; IQR:1.5 vs 3.1; IQR:3.4, respectively; p=0.77) and J-SC rate (4.5%; IQR:5.6 vs 6.2%; IQR:8.4, respectively; p=0.38). The majority of “Respiratory System” journals do not have policies discouraging A-SC. The presence of such policies is not associated with changes in IF or J-SC rate.
Understanding plateau and prairie landslides: annual report on landslide research in the Thompson River valley, British Columbia, and the Assiniboine River valley, Manitoba-Saskatchewan (2020-2021 to 2021-2022)
Authors: Huntley D , Rotheram-Clarke D , Cocking R , Joseph J , Bobrowsky P
Published: August 2022

Open File 8838 is a publication of Interdepartmental Memorandum of Understanding (IMOU) 5170 between Natural Resources Canada (NRCAN), the Geological Survey of Canada (GSC), and Transport Canada Innovation Centre (TC-IC). IMOU 5107 aims to gain new insight into
slow-moving landslides and the influence of climate changes through testing conventional and emerging monitoring technologies along strategically important sections of the national railway network in the Thompson River valley, British Columbia, and the Assiniboine River valley along the borders of
Manitoba and Saskatchewan. The results of this research will be applicable to other sites in Canada, and elsewhere around the world where slowmoving landslides and climate change are adversely affecting critical socio-economic infrastructure.
In silico design of a multi-epitope Chimera from Aedes aegypti salivary proteins OBP 22 and OBP 10
Authors: Sankar Sathish
Published: August 2022

Background & objectives:

The emergence and re-emergence of arboviruses such as dengue, Chikungunya and Zika viruses causing morbidity and mortality around the globe are of serious concern. A safe and effective vaccine is essential to control viral transmission. The salivary proteins of the mosquito that aid in blood probing, feeding and development are immunogenic. We aimed to report a multi-epitope candidate vaccine chimera from Aedes aegyptii mosquito salivary proteins OBP 22 and OBP 10 that could confer protection against all pathogens transmitted by the vector.

Methods:

Linear and conformation B-cell epitopes and MHC class-I and class-II binding T- cell epitopes were predicted using bioinformatic tools. Selected B- and T-cell epitopes were chosen for designing a multiepitope vaccine construct. The chimeric construct was analyzed for its immunogenicity, TAP and proteasomal cleavage, allergenicity, and structural validation for its suitability to be used as a candidate vaccine. Molecular docking was carried out to analyze the binding interactions with TLRs molecules.

Results:

A chimeric multiepitope vaccine was designed with the best-selected combination of immunogenic B-cell epitope, cytotoxic and helper T-cell and gamma interferon inducing epitopes with suitable adjuvant and linkers. The interacting residues between the candidate vaccine and the TLR molecules have been identified.

Interpretation & conclusion:

The proposed multiepitope candidate vaccine was designed from the mosquito salivary protein OBP 22 and OBP 10. The candidate vaccine was found promising for the protection against arboviruses. Further clinical validation is warranted to prove its efficacy, safety and immunogenicity for its potential use.
Smartphone-Based Telestroke Vs“Stroke Physician” led Acute Stroke Management (SMART INDIA)
Authors: Vishnu Venugopalan Y , Bhatia Rohit , Khurana Dheeraj , Ray Sucharita , Sharma Sudhir , Kulkarni Girish Baburao , Rao Girish N. , Mailankody Pooja , Garuda Butchi Raju , Bharadwaj Amit , Angra Monika , Ferriera Teresa , Sharma Ashish , Wilson Vinny P. , Kuthiala Neha , Sharma Sakshi , Bhasin Ashu , Mukherjee Aprajita , Agarwal Ayush , Murali Suhas , Nilima Nilima , Srivastava M.V. Padma
Published: August 2022

Background:

One of the major challenges is to deliver adequate health care in rural India, where more than two-thirds of India's population lives. There is a severe shortage of specialists in rural areas with one of the world's lowest physician/population ratios. There is only one neurologist per 1.25 million population. Stroke rehabilitation is virtually nonexistent in most district hospitals. Two innovative solutions include training physicians in district hospitals to diagnose and manage acute stroke ('Stroke physician model') and using a low-cost Telestroke model. We will be assessing the efficacy of these models through a cluster-randomized trial with a standard of care database maintained simultaneously in tertiary nodal centers with neurologists.

Methods:

SMART INDIA is a multicenter, open-label cluster-randomized trial with the hospital as a unit of randomization. The study will include district hospitals from the different states of India. We plan to enroll 22 district hospitals where a general physician manages the emergency without the services of a neurologist. These units (hospitals) will be randomized into either of two interventions using computer-generated random sequences with allocation concealment. Blinding of patients and clinicians will not be possible. The outcome assessment will be conducted by the blinded central adjudication team. The study includes 12 expert centers involved in the Telestroke arm by providing neurologists and telerehabilitation round the clock for attending calls. These centers will also be the training hub for “stroke physicians” where they will be given intensive short-term training for the management of acute stroke. There will be a preintervention data collection (1 month), followed by the intervention model implementation (3 months).

Outcomes:

The primary outcome will be the composite score (percentage) of performance of acute stroke care bundle assessed at 1 and 3 months after the intervention. The highest score (100%) will be achieved if all the eligible patients receive the standard stroke care bundle. The study will have an open-label extension for 3 more months.

Conclusion:

SMART INDIA assesses whether the low-cost Telestroke model is superior to the stroke physician model in achieving acute stroke care delivery. The results of this study can be utilized in national programs for stroke and can be a role model for stroke care delivery in low- and middle-Income countries. (CTRI/2021/11/038196)
Pure Autonomic Failure-A Localized Alpha Synucleinopathy with a Potential for Conversion to More Extensive Alpha Synucleinopathies
Authors: Bhattacharjee Shakya , Alsukhni Rana Alnasser
Published: August 2022

Pure autonomic failure (PAF) is an alpha synucleinopathy with predominant involvement of the autonomic ganglia and peripheral nerves. The hallmark clinical feature is orthostatic hypotension. However, genitourinary, sudomotor, and cardiac involvement is also common. Many patients also develop supine hypertension. Almost a quarter of patients can phenoconvert or evolve into Parkinson's disease, multiple system atrophy, and Lewy body dementia in the future. Early severe bladder involvement, higher supine noradrenaline level, early motor involvement, and dream enactment behavior increase the risk of phenoconversion. The diagnosis is confirmed via autonomic function testing and serum noradrenaline measurement. The treatment is mainly supportive. The non-pharmacological treatment includes adequate fluid, dietary salt, compression stockings, and abdominal binders. The drug therapies to improve blood pressure include midodrine, fludrocortisone, pyridostigmine, and droxidopa. The diagnostic criteria need to be updated to incorporate the recent understandings. The treatment of orthostatic hypotension and supine hypertension is mainly based on case series and anecdotal reports. Randomized control trials are needed to ascertain the best treatment strategies for PAF.
Post-Varicella Neurological Complications
Authors: Gupta Subhadeep , Biswas Atanu , Chandra Atanu , Ray Biman Kanti , Dutta Arpan , Pandit Alak
Published: August 2022

Objectives:

The objective of this study is to analyse detailed clinical presentations, imaging findings, and outcome in a series of 17 cases (n = 17) with neurological complications following acute varicella infection.

Methods:

It is an observational study on the patients who presented to the neurology outpatient department of our institute with neurological abnormalities following acute varicella infection within the last 3 months.

Results:

Neuroimaging, either computed tomography or magnetic resonance imaging, cerebrospinal fluid analysis, electroencephalography and nerve conduction studies were performed in all the patients along with other specialized investigations as per clinical context. The age of presentation varied from childhood to middle age (median age was 23 years) and range of clinical spectrum was also wide. Peripheral nervous system involvement was more common in the form of Guillain–Barré syndrome (29.4%) and isolated lower motor neuron facial nerve palsy (23.5%) compared to central nervous system (CNS) involvement. CNS involvement was documented in the form of ataxia (11.76%), myelopathy (17.6%), stroke (5.88%) and encephalitis (5.88%).

Conclusion:

Chickenpox is a common viral disease and most patients recover without any complication. Although rare, neurological complications following acute varicella infection may have myriad presentations ranging from lower motor neuron facial palsy to life-threatening encephalitis. Compared to other studies, varicella encephalitis and ataxia were not so common in our study group. Response to therapy was uniformly good except in the patients presenting with ataxia. Response was particularly good to central and peripheral demyelinating disorders.
Glucocorticoid Use and Misuse in a Rural Community of Kerala, India
Authors: Mulavelil Rachel , Finny Philip , David Alice , Samuel Preethy S. , Armstrong Lois J.
Published: August 2022

Background:

Glucocorticoids (GCs) are anti-inflammatory steroid medications prescribed globally by doctors for various illnesses and they are known to produce quick symptom relief. In India, they are among the cheapest and easily accessible over-the-counter medications. Thus, it can be misused, leading to many life-threatening illnesses such as diabetes mellitus, hypertension, overwhelming infections, Cushing’s syndrome, and hypo-adrenal crisis.

Objective:

This study reports the misuse of GCs in a rural community in the state of Kerala, India, and compares it with the only other community GC misuse study in India, from the state of Bihar.

Methods:

A community-based cross-sectional survey of 452 households comprising 1,734 people was conducted in rural Konni, Kerala, during June and July of 2019. In each house, people who had been taking medications over the previous 6 months were interviewed.

Results:

Almost 2% (n = 31) had consumed one or more GCs in the last 6 months (95% CI: 1.3–2.5%). Of these, 26% (n = 8) were taking oral GCs and 36% (n = 11) of them were inappropriately using them based on current clinical guidelines. 29% (n = 9) had used GCs for more than 1 month.

Conclusions:

GC misuse exists in Kerala but not to the extent seen in Bihar. In Kerala, inhaled GCs are more common than oral GCs, and the prescription is obtained predominantly from qualified medical practitioners. The prevalence of prolonged GC use could be implicated as an underlying factor for diabetes, hypertension, osteoporosis, and cataracts. It is possible that approximately 220,000 people in Kerala may have a suppressed hypothalamus-pituitary-adrenal axis which can predispose them to a fatal hypo-adrenal crisis.
The Comparison of the Effects of three Meals Feeding a Day and Four Meals Feeding a Day in Type 2 Diabetes Mellitus Hospitalised Patients in Thammasat University Hospital on Blood Sugar Control and Enteral Feeding Complications
Authors: Wongwatanasanti Kwansuphang , Wichansawakun Sanit
Published: August 2022

Background:

As malnutrition negatively impacts hospital outcomes, hospitalised patients should receive proper nutritional management. Enteral nutrition (EN) is the most common route for non-volitional dietary support, usually fed four times/day. It is different from patients with volitional feeding who receive only three meals/day. This practice may affect blood glucose (BG) control in enteral feeding diabetes patients and increase nursing care’s working burden. As a result, the study aimed to compare BG control and enteral feeding complications between 3 and 4 times feeding/day in hospitalised diabetes patients who require EN.

Methods:

A non-blind randomised controlled trial study was conducted in 37 types two diabetes hospitalised patients who required EN in Thammasat University hospital (TUH) from April 1 to December 31, 2019. The study patients were randomised and stratified by HbA1C at <8% or ≥8% to treat three meals or four meals/day. BG was controlled based on the insulin injection protocol of TUH. The study data was collected at least five days until the patients were stopped EN or discharged from the hospital. The primary outcome was a percentage of times BG was in controlled at ≤180mg/dl. The secondary outcomes were any feeding complications such as frequency of hypoglycemia, diarrhea and gastric residual volume over 100 ml before the next feeding time.

Results:

37 patients were included. 83% of the patients were female, and the mean age was 78.44 ± 8.14 and 74.11 ± 10.03 years old in three meals and four meals feeding group, respectively. There were none significant in mean percentage of BG control between three times and four times/day either in HbA1C <8% and HbA1C ≥8% (52.21% and 68.43%, P value = 0.192 and 54.29% and 55.10%, P value = 0.942, respectively). Percentage of hypoglycemic events were none significant in 3 vs 4 times feeding at 1.70% vs 0.99%, P value = 0.552 and 2.53% vs 2.00%, P value = 0.727 in HbA1C <8% and HbA1C ≥8%, respectively. However, other complications were not significant between two groups.

Conclusion:

There was no clinically significant outcome on BG control and other complications between three and four times feeding/day in type 2 diabetes hospitalised patients. Therefore, three times feeding can be implied in clinical practice to reduce the burden of nursing care.
Induction of Endometrial HOXA 10 Gene Expression by Vitamin D and its Possible Influence on Reproductive Outcome of PCOS Patients Undergoing Ovulation Induction Procedure
Authors: Shilpasree AS , Kulkarni Vinuta B. , Shetty Praveenkumar , Bargale Anil , Goni Mallikarjun , Oli Ajaykumar , Sarathkumar E , Patil Vidya S. , Desai Rathnamala M.
Published: August 2022

Background and Objectives:

Polycystic ovarian syndrome (PCOS) is one of the most common endocrinopathies in women frequently presenting with anovulatory infertility. Low successful pregnancy and live birth rates even after successful ovulation induction (OI) and in vitro fertilization (IVF) in these patients indicate that endometrial dysfunction may be another important factor contributing to infertility. Vitamin D acting through nuclear receptors induces the expression of various genes required for cell growth and differentiation and plays a crucial role in reproduction. Homeobox 10 (HOXA10) may be one of the potential targets for vitamin D action. HOXA10 gene product promotes the differentiation of endometrial cells, making the endometrium receptive for implantation. The present study was undertaken to determine the effect of circulating vitamin D levels on HOXA10 gene expression in endometrial tissues and its possible influence on the reproductive outcome of PCOS patients undergoing OI procedure.

Materials and Methods:

A prospective cohort study was conducted on 110 infertile PCOS patients. The patients were divided into two groups: Group 1: Vitamin D ³20 ng/ml, Group 2: Vitamin D <20 ng/ml. Endometrial samples were obtained from 22 patients using pipelle biopsy, used to determine HOXA10 mRNA (messenger ribonucleic acid) expression by quantitative RT-PCR (reverse transcription-polymerase chain reaction) and protein expression by Western blotting. OI was performed using Clomiphene citrate or Letrozole from the 3rd day of the cycle, and patients were followed up for a maximum of five cycles. Attainment of successful pregnancy was considered a positive outcome.

Results:

Both the groups were similar in mean age and other endocrine parameters. Serum vitamin D levels were significantly low (P < 0.001), and BMI (body mass index) was significantly high (P = 0.032) in group 2 compared to group 1. Endometrial HOXA10 mRNA (by quantitative rtPCR) and protein expression (by western blotting) were significantly low in group 2 compared to group 1. The clinical pregnancy rate was low in group 2 (28.6%) compared to group 1 (42.3%), but this difference was not significant (P = 0.22). On regression analysis adjusted for age and BMI, vitamin D was an independent predictor of successful pregnancy after OI (P = 0.09).

Conclusion:

Circulating vitamin D levels influence the endometrial HOXA10 gene expression, and this may be reflected on the reproductive outcome of infertile PCOS patients undergoing OI.
Implications of Cell Adhesion Molecules in Autism Spectrum Disorder Pathogenesis
Authors: Sindi Ikhlas A.
Published: August 2022

Autism spectrum disorder (ASD) is a neurodevelopmental illness that leads to repetitive behavior and debilitates social communication. Genetic changes such as susceptible genes and environmental factors promote ASD pathogenesis. Mutations in neuroligins (NLGNs) and neurexin (NRXNs) complex which encode cell adhesion molecules have a significant part in synapses formation, transcription, and excitatory–inhibitory balance. The ASD pathogenesis could partly, at the least, be related to synaptic dysfunction. Here, the NRXNs and NLGNs genes and signaling pathways involved in the synaptic malfunction that causes ASD have been reviewed. Besides, a new insight of NLGNs and NRXNs genes in ASD will be conferred.
Oral Mucous Membrane Pemphigoid
Authors: Babu Cathy , Tamgadge Sandhya , Vidhale Rutuja Gajanan , Pereira Treville
Published: August 2022

Pemphigoid is a group of rare autoimmune diseases affecting the skin and the mucous membrane in which the autoantibodies are directed against the basement membrane zone target antigens causing subepithelial blistering. Oral health professionals are usually the first to identify as more than 90% of cases show oral lesions initially. A lack of diagnostic criteria can lead to misdiagnosis and delay in treatment. We report a unique case of mucous membrane pemphigoid devoid of ocular or cutaneous involvement.
Path-lifting properties of the exponential map with applications to geodesics
Authors: Costa e Silva Ivan Pontual , Flores José Luis , Honorato Kledilson Peter Ribeiro
Published: August 2022

We revisit certain path-lifting and path-continuation properties of abstract maps as described in the work of F. Browder and R. Rheindboldt in the 1950s and 1960s, and apply their elegant theory to exponential maps. We obtain thereby a number of novel results of existence and multiplicity of geodesics joining any two points of a connected affine manifold, as well as
causal
geodesics connecting any two causally related points on a Lorentzian manifold. These results include a generalization of the well-known Hadamard–Cartan theorem of Riemannian geometry to the affine manifold context, as well as a new version of the so-called Lorentzian Hadamard–Cartan theorem using weaker assumptions than global hyperbolicity and timelike 1-connectedness required in the extant version. We also include a general description of
pseudoconvexity and disprisonment
of broad classes of geodesics in terms of suitable restrictions of the exponential map. The latter description sheds further light on the relation between pseudoconvexity and disprisonment of a given such class on the one hand, and geodesic connectedness by members of that class on the other.
YouTubers y dietas milagros: la difusión de contenidos de salud entre 2020 y 2021
Authors: Castillo Abdul Hadi Barbara , Blanco-Herrero David , Muela-Molina Clara
Published: August 2022

Introducción: La presente investigación profundiza en la posible influencia de factores poco estudiados en la interacción que despiertan los vídeos de YouTube sobre dietas milagro, dado el potencial riesgo de salud pública que pueden suponer los consejos que ofrecen, especialmente para la población joven. Metodología: Se analizaron los 50 vídeos más vistos sobre dietas rápidas subidos entre enero de 2020 y junio de 2021 en español y en inglés. A través de un análisis de contenido cuantitativo se estudió la influencia de variables sobre la relación con la audiencia y la presencia en cámara, la expresión de emociones y la descripción y análisis de la dieta o producto sobre la interacción y consumo del video. Resultados: Los factores estudiados no tienen apenas efecto, como tampoco lo tuvo el idioma, en las cifras de visionados, comentarios, likes, dislikes y compartidos. Discusión: Lo anterior se interpreta como señal de un consumo acrítico e irreflexivo, lo que podría suponer riesgos si la audiencia sigue dietas o consume productos que puedan suponer un riesgo para la salud. Conclusiones: El trabajo aspiraba a abrir nuevas vías de análisis de contenidos de salud en YouTube poniendo el foco en características de los vídeos menos estudiadas en la literatura previa. A pesar de los escasos efectos observados, se plantea la necesidad de seguir abordando factores como las emociones transmitidas, el tipo de información utilizada o la actitud hacia los productos o dietas tratados.
Классификация инволютивных коммутативных двузначных групп
Authors: Buchstaber Victor Matveevich , Veselov Aleksandr Petrovich , Gaifullin Alexander Aleksandrovich
Published: August 2022

Получена полная классификация конечно порожденных инволютивных коммутативных двузначных групп. Построены три серии таких двузначных групп: основная, унипотентная и специальная - и показано, что любая конечно порожденная инволютивная коммутативная двузначная группа изоморфна двузначной группе, принадлежащей одной из этих серий. Получен ряд классификационных результатов для топологических инволютивных коммутативных двузначных групп в хаусдорфовом и локально компактном случаях. Обсуждается также классификация алгебраических инволютивных двузначных групп в одномерном случае.
Библиография: 45 названий.
Association between polymorphic eNOS gene markers and risk of primary open-angle glaucoma in the Perm Region population
Authors: Gavrilova Tatyana V. , Kinkulkina Aliya R. , Avagyan Hasmik S. , Svitich Oksana A.
Published: August 2022

Glaucoma is widely known to have a progressive course and occupy a leading place among the causes of vision loss and blindness. Increased intraocular pressure is the key harmful factor among the causes of glaucoma occurrence. In some cases, however, the progressive disease is also observed at normal values of ophthalmic tonus. Early diagnosis of glaucoma will allow for timely therapy, which in turn will reduce the risk of complications and prevent neuroopticopathy progression. According to the literature data, the pathogenesis of primary open-angle glaucoma is associated with nitric oxide (NO), due to imbalance between endothelium-produced vasoconstrictors and vasodilators, especially, endotelin-1 and nitric oxide. Decreased NO level combined with endotelin-1 hyperproduction is associated with development and progression of a number of ocular disorders including glaucomatous atrophy of the optic nerve. Since nitric oxide is produced by endothelial NO-synthase (eNOS), one may assume that eNOS is involved in pathogenesis of neurodegenerative changes in primary open-angle glaucoma. However, despite numerous studies on the pathogenesis of glaucoma, the distinct factors of innate immune response remain poorly studied. The purpose of the present study was a search for association between polymorphic markers (C774T, T786C, Glu298Asp) of the eNOS gene and the risk of primary open-angle glaucoma among the Perm Region residents.

Peripheral blood of patients with primary open-angle glaucoma (the main group) and cataract without glaucoma (a comparison group) was used as initial biomaterial. In comparison group, arterial hypertension was most often encountered as concomitant pathology. Genomic DNA was first isolated from the blood samples, followed by rt-PCR using reagent kits for determining C774T, T786C, Glu298Asp polymorphic markers in the eNOS gene.

The prevalence of polymorphic variants of the innate immunity genes T786C, C774T and Glu298Asp of the eNOS gene was analyzed in patients with primary open-angle glaucoma. There were no significant differences in the distribution of genotypes and alleles of eNOS gene for the C774T and Glu298Asp polymorphic markers. An increased frequency of homozygous TT genotype was found, along with decreased occurrence of C allele at the polymorphic T786C locus of the eNOS gene, as well as a trend for decreased frequency of the TC and CC genotypes. Arterial hypertension potentiated the negative effect of increased intraocular pressure upon the glaucoma-associated optic neuropathy. Conclusions. The studied changes in genotypes and allelic frequencies of eNOS gene may be regarded as risk factors that increase probability of the primary open-angle glaucoma and predict severity of the disease.