bluuebunny/crossref_metadata_2025 huggingface dataset:
«Escucha el Desierto del Sonido»
Authors: Gonzalo Carbó Antoni
Published: July 2023

La campana de bronce es un elemento simbólico muy relevante en la obra del artista visual italiano Claudio Parmiggiani (Luzzara, 1943). El simbolismo de la campana está sobre todo en relación con la percepción del sonido. Sin embargo, la campana lombarda que el artista instaló en el antiguo oratorio de San Lupo (Bérgamo, 2014) estaba colgada del techo con una cuerda, atada por el badajo: una campana que tañe «el gran silencio» (dem großen Schweigen), suspendida sobre el amplio agujero negro del suelo, la oquedad insondable (abgrunt o Abgrund, ‘fondo sin fondo’ o ‘Abismo’, Eckhart, Heidegger). Es la inversión de la campana soñada por Boriska (Andréi Rubliov, 1966, Andréi Tarkovski): no la que genera el movimiento del silencio al sonido, sino, en movimiento inverso, del sonido al silencio. Asimismo, el compositor siciliano Salvatore Sciarrino (Palermo, 1947), reduce el sonido hasta el susurro por medio de la dinámica musical «crescendo dal nulla», «diminuendo al niente», «dal nulla al nulla», «con el objetivo de expresar la nada que genera el sonido, a la que vuelve brillando». Dos creadores italianos, pues, con una pareja estética apofática de la Nada y el Silencio absoluto. Un viaje a través del vacío sonoro en el curso del cual el oído del poeta queda deslumbrado: «Escuché cosas que no son audibles» (die nicht hörbar sind).
Tras el Azafrán Minoico
Authors: Morro Mas Antoni Miquel
Published: July 2023

Este ensayo propone el abordaje mitopoiético de la cultura material minoica en la práctica artística contemporánea. En primer lugar, partiendo de fuentes arqueológicas se enfatiza su singularidad, de la que pueden obtenerse aprendizajes significativos y un enfoque holístico ante los actuales debates de género, espirituales y medioambientales. En segundo lugar, se presta atención a uno de sus programas pictóricos, propuesto aquí como ejemplo  paradigmático en la convergencia del arte, sociedad, economía y religión minoicas. Y en tercer lugar, entendiendo que la práctica artística puede promover una comprensión del mundo más unitaria y afectiva, se propone un desarrollo escultórico con la mujer posicionada como sujeto principal, para contribuir a la deconstrucción del paradigma dual que determina las relaciones entre las personas y como aporte a la espiritualidad feminista.
Promoting Social Interaction and Attention of Students with Disabilities through Interactive Groups
Authors: García-Carrión Rocío , Gutiérrez-Esteban Prudencia , Fernández-Villardón Aitana , Ayuso-Del Puerto Desireé
Published: July 2023

Academic learning and social skills are internalized through interactions and dialogue. However, students with disabilities have limitations at engaging in social interactions, affecting their educational experience. This case study analyses how a particular interactive learning environment, named Interactive Groups (IG), fosters quality interactions among students with disabilities. Five sessions of IG involving 20 students with disabilities in a special education setting were analysed. In total, 5831 interactions among the students were coded based on verbal and nonverbal communication. Besides, interviews with teachers and volunteers, and a focus group with students were conducted. Results show a high presence of attentional engagement towards the task, along with increased helping interactions. Benefits in terms of social skills and curricular development, fostering the acquisition of adaptative behaviours are identified.
Corpus Linguistics on the Impression Management Strategy of Indonesian Public Officials after Covid-19 Denial Statements
Authors: Pratiwi Miftha , Andarini Rindang Senja , Setiyowati Rini , Santoso Anang Dwi
Published: July 2023

With the Covid-19 pandemic, public officials in Indonesia were prone to making inaccurate claims and to enacting policies that the public might have overlooked due to a lack of understanding of complex situations. However, after making these mistakes, public officials needed to restore their reputation and create a positive impression. This study aimed to investigate the impression management strategies employed by Indonesian public officials following such incidents. The researchers analysed a dataset of 2,000 Instagram captions from seven public officials over the course of a year, totalling 13,725 words and 196,154 tokens, using corpus linguistic techniques such as frequent words and keyword lists. The findings revealed that officials used different strategies such as ingratiation, self-promotion and supplication to manage their impression, and that positive attitudes and hard work were the main tools used by officials to improve their public image.
Impact of sexual and neurogenic lower urinary tract dysfunction on multiple sclerosis patients' quality of life and health perceptions
Authors: EŞKUT Neslihan , KÖŞKDERELİOĞLU Aslı
Published: July 2023

Purpose: To investigate the impact of neurogenic lower urinary tract dysfunction (NLUTD) and sexual dysfunction (SD) on multiple sclerosis (MS) patients' quality of life and health perceptions and evaluate the possible relationship with disease parameters.

Materials and Methods: A total of 192 patients with MS were included in the study. Along with the King's Health (KHQ) and COOP/WONCA questionnaires, Arizona Sexual Experience Scale (ASEX), Beck Depression Scale (BDI), Monitoring My Multiple Sclerosis Scale (MMMS) were used to evaluate the patients’ quality of life and self-perception of health.

Results: The median age of the patients was 39.5 years (18–66 years). In contrast, SD was present in 34.4%, 51.6% of the patients presented with NLUTD. Patients with NLUTD had significant differences in terms of age, education level, duration of disease, EDSS, BDI, ASEX, and MMMS scores. The majority of the study group had minor disability (82.8% had an EDSS score less than 3). Patients with SD showed higher disability, depression, and disrupted self-perception of their health status. In addition, quality of life measures correlated with the presence of NLUTD, SD and depression along with higher disability and altered self perception of their health status.

Conclusion: NLUTD and SD significantly effect quality of life and well being. Increasing awareness about the impact of NLUTD and SD symptoms in patients with MS will provide a comprehensive approach in clinical practice.
Modulatory effects of Hypericum perforatum extract on sciatic nerve injury-induced peripheral neuropathy: an experimental study on mice
Authors: SARIYILDIZ Aylin , KAPLAN Halil Mahir , ŞİNGİRİK Ergin , KOZANOGLU Erkan
Published: July 2023

Purpose: The effect of Hypericum perforatum (HP), which is a medicinal plant, on sciatic nerve injury-induced peripheral neuropathy has been less studied so far. The current experimental study aimed to investigate the neuroprotective and antinociceptive effects of Hypericum perforatum (HP) extract on sciatic nerve injury-induced peripheral neuropathy in mice.

Materials and Methods: In the present study, 18 Balb/C albino mice were allocated equally into three groups. The first group was determined as controls, and no procedure was performed on these mice. Neuropathy was generated by the partial sciatic nerve ligation method on mice allocated to the second and third groups. Mice in the third group received HP extract at a dose of 70 mg/kg per day for fourteen days. Nociception (cold allodynia) was evaluated using the cold plate test at the end of the experimental period. Tumor necrosis factor –αlpha (TNF-α) and interleukin-6 (IL-6) in plasma; inducible nitric oxide synthase (iNOS), phospholipase A2, cyclooxygenase-2 (COX-2), nuclear factor-kappa B (NF-κB), caspase-3, Bcl-2, and Bax levels in sciatic nerve were measured by enzyme-linked immunosorbent assay test.

Results: Cold plate latencies (sec) of the neuropathy + HP, neuropathy, and control groups were 8.33 ± 0.67, 5.17 ± 0.60, and 13 ± 0.73, respectively. Plasma TNF-α, IL-6 levels, and sciatic nerve iNOS, COX-2, NF-κB, caspase-3, and Bax levels were significantly decreased after HP supplementation. Bcl-2 levels of the neuropathy + HP, neuropathy, and control groups were 9.92 ± 0.71, 5.37 ± 0.53, and 13.65 ± 0.68, respectively.

Conclusion: HP has improved oxidative, inflammatory, and apoptotic responses, as well as cytokine levels in plasma and sciatic nerves of mice. It has been concluded that HP provided neuroprotective, anti-inflammatory, and antinociceptive effects in experimental mice with sciatic nerve injury models, which is suggested to guide future studies on neuropathic pain management.
Rosuvastatin relaxes rat thoracic aorta, pulmonary artery, and trachea via nitric oxide, prostanoids, and potassium channels
Authors: ŞAHİNTÜRK Serdar
Published: July 2023

Purpose: This study aimed to determine the functional effects and mechanisms of the action of rosuvastatin on vascular and tracheal smooth muscle tissues.

Materials and Methods: Vascular and tracheal rings (2-3 mm) isolated from the thoracic aortas, pulmonary arteries, and tracheas of Wistar Albino male rats (250-300 g) were placed in chambers in the isolated tissue bath system. As the resting tension, 1 g was selected. Vascular rings contracted with 10-6 M phenylephrine after a 90-minute equilibration period. Tracheal rings contracted with 10-5 M acetylcholine. After the contraction was steady, rosuvastatin (10-8-10-4 M) was cumulatively applied to the vascular and tracheal rings. The defined experimental methodology was repeated following the incubation of selective inhibitors of signaling pathways and K+ channel blockers to ascertain rosuvastatin's functional effect mechanisms.

Results: In the precontracted rat vascular and tracheal rings, rosuvastatin induced concentration-dependent relaxation. The maximal relaxation level in vessel samples was 96%. On the other hand, the maximal relaxation level in tracheal samples was found to be 75%. The vasorelaxant effects of rosuvastatin were dramatically attenuated by endothelium removal, L-NAME treatment, and indomethacin incubation (up to 27%). With the incubation of tetraethylammonium, glyburide, 4-Aminopyridine, and anandamide, rosuvastatin-mediated vascular smooth muscle relaxation levels were significantly decreased (up to 38%). Moreover, With the incubation of tetraethylammonium, glyburide, and 4-Aminopyridine rosuvastatin-mediated tracheal smooth muscle relaxation levels were significantly decreased (up to 30%).

Conclusion: Rosuvastatin has a noticeable relaxing effect on the vascular and tracheal smooth muscles. The vasorelaxant effect of rosuvastatin involves intact endothelium, nitric oxide, prostanoids, and K+ channels (BKCa, KV, and KATP channels). Furthermore, nitric oxide, prostanoids, BKCa channels, KV channels, and KATP channels play a role in rosuvastatin-induced tracheal smooth muscle relaxation
Los créditos universitarios en los procedimientos concursales de liquidación voluntaria. Una mirada desde la jurisprudencia chilena
Authors: Martínez Montenegro Isnel , González Cerda Ismael , San Martín Valdés Sol
Published: July 2023

El 09 de octubre de 2014 se reforma en Chile la antigua ley de quiebras con la nueva ley N° 20.720 de Insolvencia y Reemprendimiento, creando para tal efecto el procedimiento concursal de liquidación voluntaria. Su objetivo es entregar herramientas jurídicas a aquellos deudores que se encuentren en una inviabilidad económica mediante la liquidación inmediata de sus activos (patrimonio) y extinción de todos sus pasivos (deudas), optando a la rehabilitación económica. Sin embargo, se ha generado la discusión ante la Excelentísima Corte Suprema de Justicia, si los créditos universitarios pueden incluirse dentro de los pasivos del deudor en estos procedimientos, ante la falta de regulación legal al respecto.
Kalwina koncepcja wolnej woli i usprawiedliwienia
Authors: Nowakowski Dawid
Published: July 2023

Calvin in popular imagination functions as a radical antagonist of rationalism and as an extreme advocat of predestination. This article, primarily on the base of analysis of Institutio Christiane religionis, shows that his doctrines are neither so distant from the theological and philosophical traditions, or so devoid of logical structure, as is commonly believed. When Calvin's conceptions of free will and justification are placed in a broader epistemological and anthropological perspective, a detailed analysis of his thought system shows that the idea of predestination is not his objective, but rather a logical extension.
Libres para creer. La conversión según Bartolomé de las Casas en la Historia de las Indias
Authors: Castillo Mattasoglio Carlos
Published: July 2023

El Departamento de Teología de la Pontificia Universidad Católica del Perú se complace en presentar la obra "Libres para Creer" del P. Carlos Castillo Mattasoglio, Doctor en Teología, miembro de nuestro Departamento. En su libro nos ofrece una honda reflexión teológica sobre el tema histórico. Se trata del análisis de la importante obra de Bartolomé de las Casas: "Historia de las Indias" en lo referente al tema de la teología de la conversión. que el autor del siglo XVI aborda con profundidad y creatividad. Por tratarse de la última y más importante obra de este profeta de los indios. resulta iluminador seguir los detalles de una reflexión, que en su tiempo significaba un planteamiento realmente nuevo. acerca del problema de la conversión de indios y españoles en una situación polémica de injusticia y pobreza. Nuestro Departamento quiere así contribuir a la reflexión que en Latinoamérica se ha desarrollado con ocasión del V Centenario de la Evangelización. Creemos que esta obra de Carlos Castillo constituye un serio aporte.
Albañilería estructural
Authors: Gallegos Héctor , Casabonne Rasselet Carlos
Published: July 2023

Enriquecer la formación y profundizar el arte de la ingeniería son la justificación más profunda para que el presente libro se haya hecho y para que tenga el contenido y la forma que le hemos dado. El libro analiza, por ello, los conceptos básicos y procura dar a conocer el comportamiento del material posibilitando que, al entendérsele, se lo aplique correctamente, bajo cualquier receta o reglamento, e incluso a pesar de ellos. Esto explica que se hayan esquivado los aspectos reglamentarios, que se haya perseguido exclusivamente el conocimiento del material y que se haya evitado también, por el mismo motivo, incluir las partes tradicionales, usuales en libros que tratan materiales estructurales, en lo que se refiere a su cálculo y dimensión. El ordenamiento está hecho sobre la base del sílabo que elaboró el autor cuando comenzó el dictado del curso de Albañilería Estructural en la Pontificia Universidad Católica del Perú, en el año 1978, y que ha ido modificando conforme el conocimiento general, y el suyo propio, progresaban. Dicho sílabo no se incluye como parte principal del curso sino como parte de las prácticas, los reglamentos, el cálculo y el dimensionamiento. El libro ha sido escrito en una secuencia lógica de temas y está provisto con índices de acceso, particularmente el alfabético; ofrece, además, una nutrida bibliografía -a la cual se hace referencia en el texto indicando los números entre corchetes- lo que facilitará su uso como instrumento de consulta y referencia. El objetivo de este libro es servir. Servir tanto al profesional -ingeniero o arquitecto- en el ejercicio del diseño, construcción y supervisión, como al estudiante de estas disciplinas. Servir a la ingeniería. Servir, en última instancia, al hombre.
Constructing and regulating nanochannels in two-dimensional-material-based membranes for specified separation applications
Authors: Xing Chao , Zhang Mengchen , Liu Lingfeng , Zheng Zehua , Zhou Ming , Zhang Shanqing , Liu Changyu
Published: July 2023

The two-dimensional (2D) materials offer atomic-level thickness and unique physical and chemical properties for the preparation of a new class of membranes, i.e., nanochannel membranes. The nanochannel membranes have been utilized in a broad spectrum of new separation applications. However, the instability of the nanochannels, interfacial instability of 2D materials, and the swelling problem could damage the membrane performance, such as permeability, selectivity, and service lifetime. Innovative strategies for constructing and regulating the nanochannels are enthusiastically explored to address these challenges. Along this line, in this work, we first provide insight into the mechanisms of the nanochannel construction, the separation mechanism, and the effect of nanochannels on the separation performance. Then, the strategies developed in the literature, in particular, the strategies for the preparation of ideal 2D nanosheets, the strategies for constructing nanochannels, and the strategies for regulating the characteristics of nanochannels (channel size, channel length, channel morphology, and channel surface physicochemical properties) are systematically summarized. After that, we briefly introduce the application of 2D-material-based nanochannel membranes and outline the current challenges and provide an outlook in the further exploration of separation mechanism, large-scale manufacturing, and the eventual commercialization of the membranes.
Wireless batteryless soft sensors for ambulatory cardiovascular health monitoring
Authors: Guess Matthew , Soltis Ira , Rigo Bruno , Zavanelli Nathan , Kapasi Sara , Kim Hyeonseok , Yeo Woon-Hong
Published: July 2023

Seismocardiography (SCG) is the measure of local vibrations in the chest due to heartbeats. Typically, SCG signals are measured using rigid integrated circuit (IC) accelerometers and bulky electronics. However, as alternatives, recent studies of emerging flexible sensors show promise. Here, we introduce the development of wireless soft capacitive sensors that require no battery or rigid IC components for measuring SCG signals for cardiovascular health monitoring. Both the capacitive and inductive components of the circuit are patterned with laser micromachining of a polyimide-coated copper and are encapsulated with an elastomer. The wearable soft sensor can detect small strain changes on the skin, which is wirelessly measured by examining the power reflected from the antenna at a stimulating frequency. The performance of the device is verified by comparing the fiducial points to SCG measured by a commercial accelerometer and electromyograms from a commercial electrode. Overall, the human subject study demonstrates that the fiducial points are consistent with data from commercial devices, showing the potential of the ultrathin soft sensors for ambulatory cardiovascular monitoring without bulky electronics and rigid components.
Similaridades teóricas entre os pensamentos de Milton Santos e Ortega y Gasset
Authors: Costa Hugo Aureliano da
Published: July 2023

Este ensaio objetiva apresentar como o pensamento de Milton Santos é ressignificado a partir da obra do filósofo Ortega y Gasset, demonstrando as similaridades entre os pensamentos dos dois teóricos. Portanto, defendemos a hipótese que as estruturas do pensamento orteguiano contribuem de forma clara para a construção da geografia de Milton Santos. Para isso, foi realizada uma pesquisa bibliográfica de cunho teórico apoiada nas principais obras do filósofo espanhol e do geógrafo brasileiro com o intuito de compreender as interligações e similaridades dos pensamentos desses dois autores.
The evaluation of the use of jack bean (Canavalia ensiformis) and protease enzyme on the broiler diet with the different level of protein
Authors: Mahardhika Brahmadhita Pratama , Ridla Muhammad , Mutia Rita , Febriani Sisca , Purbaya Agung Mayandika
Published: July 2023

Objective: This study evaluated the use of jack beans (Canavalia ensiformis) and protease enzymes in broiler chicken feed. The protein levels on carcasses and the efficiency of the diet were assessed based on protein efficiency ratio, nitrogen retention, percentage of immunity organs, and feed economic analysis based on Income Overfeed Conversion.

Methods: The factorial complete randomized design (CRD) was employed in this study, piloting three treatment factors: protein level (22% and 19.5%), protein source material (basal diet and jack bean), and the use of enzymes (without enzymes and protease supplementation). Moreover, three replications were conducted, consisting of two samples of broiler chickens per replication. Forty-eight male broiler chickens from 240 populations that had previously been reared for 28 days were taken as the sample of the study.

Result: The results showed that the use of jack beans significantly decreased the dress body weight (P<0.05), undress body weight, and carcass weight of broiler chickens. In addition, the weight significantly increased IOFC by (P<0.01). The use of protease enzymes significantly (P<0.05) increased Retention Nitrogen, Protein Eficiency Ratio, and carcass. The feed protein level decreased substantially by (P<0.01). It reduced protein consumption, RN, PER, dress, undress, and carcass body weight. The use of jack bean did not affect the broiler's immune organ size.

Conclusion: The use of protease enzymes in diets with low protein levels can produce dress body weight, carcass body weight, RN, and PER, similar to basal diets, without affecting the size of the immune organs of broiler chickens.
Assuring Customer Value, Customer Experience, and Trust to Improve Customer Loyalty
Authors: Indah Febriyanti  , Tuti Meylani
Published: July 2023

Consumer loyalty may be influenced by consumer trust. Consumer experience and customer value are only two of the many elements that contribute to consumer trust. Through consumer trust, this study seeks to examine the impact of customer value and customer experience on customer loyalty. Purposive sampling was the sampling method utilized, and 162 purchasers had made purchases more than twice. SmartPLS was used to conduct the analytical procedure utilizing structural equation modeling (SEM). According to the study's findings, trust and loyalty are influenced by both the customer experience and the value of the customer. Similarly, loyalty is influenced by the trust.
Praktik Jual Beli Saren untuk Pengobatan Perspektif Hukum Islam
Authors: Munawaroh Nadhatul , Abdullah Fuady , Ningrum Trisna Setya
Published: July 2023

In the modern era like today, there are still many traditional products circulating whose benefits have not been clinically tested. One of these products is saren which is made from chicken blood. The use of saren as a drug is not based on advice or advice from medical experts. So, it is not known for certain whether the saren is good for consumption or not, especially for health. Moreover, the perpetrators in the transaction are Muslims. Thus, this study was conducted to find out how Islamic law reviews the practice of buying and selling, as well as what factors are behind the practice of buying and selling saren for the drug. The approach used in this research is a qualitative approach (field research), while the data collection uses the methods of observation, interviews and documentation. From the results of this study it can be concluded that the saren product is unclean and forbidden in Islamic law. Even though the saren product has undergone various production processes, the law is still haram and there is no istiḥālah on it. In addition, from a medical point of view, in the saren there are also toxic substances that can harm people who consume it. So that the use of saren as a medicine is just a belief of the local community. The factors behind the practice of buying and selling saren for these drugs are based on economic factors, cultural factors, religious and educational factors.

Pada era modern seperti sekarang ini, masih banyak beredar produk tradisional yang manfaatnya belum teruji secara klinis. Salah satu produk tersebut adalah saren yang terbuat dari darah ayam. Penggunaan saren sebagai obat tersebut tidak berdasarkan saran atau anjuran dari ahli medis. Sehingga tidak diketahui secara pasti apakah saren tersebut baik untuk dikonsumsi atau tidak, terutama untuk kesehatan. Apalagi para pelaku dalam transaksi tersebut adalah seorang muslim. Dengan demikian, penelitian ini dilakukan untuk mengetahui bagaimana hukum Islam meninjau praktik jual beli tersebut, serta faktor apa saja yang melatar belakangi terjadinya praktik jual beli saren untuk obat tersebut. Pendekatan yang digunakan pada penelitian ini adalah pendekatan kualitatif (field research), sedangkan pengumpulan datanya menggunakan metode observasi, wawancara dan dokumentasi. Dari hasil penelitian ini dapat disimpulkan bahwa produk saren tersebut hukumnya najis serta diharamkan dalam hukum Islam. Meskipun produk saren tersebut telah mengalam beragai proses produksi, hukumnya tetaplah haram dan tidak ada istiḥālah atasnya. Selain itu dari segi medis, di dalam saren juga terdapat zat racun yang dapat membahayakan orang yang mengkonsumsinya. Sehingga penggunaan saren sebagai obat tersebut hanyalah sekedar kepercayaan masyarakat setempat. Adapun yang menjadi faktor yang melatarbelakangi terjadinya praktik jual beli saren untuk obat tersebut adalah karena didasari oleh faktor ekonomi, faktor budaya, faktor agama dan pendidikan.
Akad Qardh Perspektif Fatwa DSN-MUI tentang Qardh
Authors: Ikafitria Rakhma , Wahid Soleh Hasan , Islami Lutvia Izzul , Putri Rahma Zafira
Published: July 2023

The purpose of this research is to explore the system of lending money under other people's names from the perspective of the DSN-MUI fatwa No. 19/DSN-MUI/IV/2001 Regarding Qardh in the Ngudi Makmur Farmer Group Association of Magetan, and what is the default settlement system? This study uses field research methods. At the same time, data collection is done through interviews, documentation, and observation. This observation concluded that the Ngudi Makmur Farmers Group Association gave illegal loans in other people's names. Because according to the DSN-MUI fatwa No. 19/DSN-MUI/IV/2001, Qardh is a loan given to a customer in need, and the card's terms, it is also explained that a loan is considered valid if the person holding the loan is the borrower. However, in this case, the management of Gapoktan Ngudi Makmur provides loans to non-members in the name of members, where members have died, but their names are used for loans of money by other people who are not members. Then the default dispute resolution system in Gapoktan Ngudi Makmur uses non-litigation channels, namely by negotiations carried out by deliberation between the parties, namely the combined management of the Ngudi Makmur farmer group and members who experience defaults to find a fair way out of the problems at hand. The settlement of defaults at Gapoktan Ngudi Makmur is by the DSN-MUI fatwa No. 19/DSN-MUI/IV/2001 Concerning Qardh.

Tujuan penelitian ini untuk mengeksplorasi sistem pemberian pinjaman uang dengan nama orang lain perspektif fatwa DSN-MUI No. 19/DSN-MUI/IV/2001 Tentang Qardh Pada Gabungan Kelompok Tani Ngudi Makmur Magetan, serta bagaimana sistem penyelesaian wanprestasinya? Dalam penelitian ini menggunakan metode penelitian lapangan. Sedangkan pengumpulan data dilakukan melalui wawancara, dokumentasi, dan observasi. Dari proses pengamatan ini disimpulkan bahwa Gabungan Kelompok Tani Ngudi Makmur memberikan pinjaman uang dengan nama orang lain tidak sah. Karena menurut fatwa DSN-MUI No. 19/DSN-MUI/IV/2001, Qardh adalah pinjaman yang diberikan kepada nasabah yang membutuhkan dan dalam syarat qardh juga dijelaskan bahwa pinjamanadianggap sah apabila yang memegang pinjaman adalah peminjam. Namun, dalam permasalahan ini pengurus Gapoktan Ngudi Makmur memberikan pinjaman uang kepada bukan anggota dengan nama anggota, dimana anggota sudah meninggal tetapi namanya digunakan untuk pinjaman uang oleh orang lain yang bukan anggota. Kemudian sistem penyelesaian sengketa wanprestasi di Gapoktan Ngudi Makmur menggunaan jalur non litigasi yaitu dengan negosiasi yang dilakukan dengan musyawarah oleh antara para pihak yaitu pengurus gabungan kelompok tani Ngudi Makmur dengan anggota yang mengalami wanprestasi untuk mencari jalan keluar yang adil dari permasalahan yang dihadapi. Penyelesaian wanprestasi di Gapoktan Ngudi Makmur ini sudah sesuai dengan fatwa DSN-MUI No. 19/DSN-MUI/IV/2001 Tentang Qardh.
Minimization of Cancer Cells with ATS Fuzzy Controller: An Application to Androgen Deprivation therapy
Authors: Dubey Priya , Kumar Surendra
Published: July 2023

Androgen deprivation therapy (ADT) is commonly used to treat prostate
cancer, but its 5-year survival rate remains low at 57%. Prolonged
ADT treatment can lead to increased toxicity and drug resistance. To
address these challenges, this study proposes adaptive therapy that
combines chemotherapy or immunotherapy with discontinuation of hormone
therapy. The study applies the super-twisting sliding mode control
(STSMC) algorithm to the ADT model to implement adaptive dosing
based on control laws derived from these algorithms. The main
objective is to quickly minimize cancer cells and reduce prolonged drug
exposure. An active control algorithm (ATS)-based Takagi-Sugeno fuzzy
controller is also introduced and compared to the STSMC design. The
ATS fuzzy controller significantly reduces therapy duration to six months
while maintaining global asymptotic stability. The controllers are implemented
using the Linear Matrix Inequality (LMI) algorithm and the
YALMIP toolbox, and their effectiveness is validated through MATLAB
and Simulink simulations. This study presents a novel approach
to improve prostate cancer treatment outcomes by integrating nonlinear
control algorithms and adaptive dosing strategies, aiming to reduce
treatment duration and minimize drug exposure, ultimately enhancing
patient outcomes in prostate cancer management.
The influence of oxygen and oxidative stress on de novo acquisition of antibiotic resistance in E. coli and Lactobacillus lactis
Authors: Qi Wenxi , Jonker Martijs J. , Teichmann Lisa , Wortel Meike , Kuile Benno H. ter
Published: July 2023

Background: Bacteria can acquire resistance through DNA mutations in response to exposure to sub-lethal concentrations of antibiotics. According to the radical-based theory, reactive oxygen species (ROS), a byproduct of the respiratory pathway, and oxidative stress caused by reactive metabolic byproducts, play a role in cell death as secondary killing mechanism.
Results: To investigate whether oxygen and ROS affect de novoacquisition of antibiotic resistance, evolution of resistance was compared in E. coli wildtype and ΔoxyR strains under aerobic and anaerobic conditions. Since Lactococcus lactis (L. lactis) does not have an active electron transport chain (ETC) even in the presence of oxygen, and thus forms much less ROS, resistance development in L. lactis was to distinguish between oxygen and ROS. The resistance acquisition in E. coli wildtype under aerobic and anaerobic conditions did not differ much. However, the aerobically grown ΔoxyR strain gained resistance faster than the wildtype or anaerobic ΔoxyR. Inducing an ETC by adding heme increased the rate at which L. lactis acquired resistance. Whole genome sequencing identified crucial mutations involved in the acquisition of resistance. These mutations were specific for each antibiotic. The lexA mutation in ΔoxyR strain under aerobic conditions indicated that the SOS response was involved in resistance acquisition.
Conclusions: The concept of hormesis can explain the beneficial effects of low levels of ROS and reactive metabolic byproducts, while high levels are lethal. DNA repair and mutagenesis may therefore expedite development of resistance. Taken together, the results suggest that oxygen as such barely affects resistance development. Nevertheless, non-lethal levels of ROS stimulate de novo acquisition of antibiotic resistance.
A mHealth Intervention to Reduce Perceived Stress in Patients with Ischemic Heart Disease: Study Protocol for the Randomized, Controlled Confirmatory Intervention ‘mStress-IHD’ Trial
Authors: Lortz Julia , Rassaf Tienush , Jansen Christoph , Knuschke Ramtin , Schweda Adam , Schnaubert Lenka , Rammos Christos , Köberlein-Neu Juliane , Skoda Eva-Maria , Teufel Martin , Bäuerle Alexander
Published: July 2023

Background
Stress is highly prevalent in patients with ischemic heart disease (IHD) and is associated with lower health-related quality of life and impaired cardiovascular outcome. The importance of stress management is now recognized in recent guidelines for the management of cardiovascular disease. However, effective stress management interventions are not implemented in clinical routine yet. The development of easily disseminated eHealth interventions, particularly mHealth, may offer a cost-effective and scalable solution to this problem. The aim of the proposed trial is to assess the efficiency and cost-effectiveness of the mHealth intervention ‘mindfulHeart’ in terms of reducing stress in patients with IHD.
Methods and analysis:
This randomized controlled confirmatory interventional trial with two parallel arms has assessments at six measurement time points: baseline (T0, prior randomization), post treatment (T1) and four follow-ups at month 1, 3, 6, and 12 after intervention (T2, T3, T4, and T5). We will include patients with confirmed diagnosis of IHD, high-perceived stress, and use an internet-enabled smartphone. Patients will be randomized into two groups (intervention vs. control). The proposed sample size calculation allocates 128 participants in total. The primary analysis will be performed in the intention-to-treat population, with missing data imputed. An ANCOVA with the outcome at T1, a between-subject factor (intervention vs. control), as well as the participants’ pre-intervention baseline values as a covariate will be used. Different ANOVAs, regression and descriptive approaches will be performed for secondary analyses.
Discussion
The randomized controlled ‘mStress-IHD’ trial aims to assess the efficacy and cost-effectiveness of the mHealth intervention ‘mindfulHeart’ for reducing stress in patients with IHD. A successful stress reduction in IHD patients with an increase of quality of life could be an important component of secondary prevention. Thus, the investigation related to the impact of the mHealth solution ‘mindfulHeart’ can lead to beneficial findings.
Ethics:
The Ethics Committee of the Medical Faculty of the University of Duisburg-Essen approved the study (22-11015-BO).
Trial registration number:
ClinicalTrials identifier NCT05846334
Tango-therapy vs physical activity in older people with dementia. A randomized controlled trial
Authors: Bracco Lucia , Pinto-Carral Arrate , Hillaert Linda , Mourey France
Published: July 2023

Background: dementia is a growing health concern that affects millions of people worldwide. Balance and gait disorders are often present and represent a major risk factor for falls. We investigated the effectiveness of tango-therapy in older people with dementia.
Methods: A randomised controlled trial with 31 participants living in a specialised Alzheimer disease unit, aged 65 to 93 years old, who were randomly assigned to tango group (IG) or adapted physical activity group (CG). Physical abilities (gait speed, Timed Up and Go test, Short Physical Performance Battery), ability to perform activities of daily living (Katz Index) and quality of life (Quality of life in Alzheimer Disease) were assessed. Measurements were performed at baseline, and after one and three months of training.
Results: after 3 months IG improved gait speed (p=0.035) while CG worsened (p=0.273), implying a statistically significant difference between groups (p=0.049). Both groups declined in their ability to perform activities of daily living, being statistically significant only in the CC (p=0.004). Both groups improved their quality of life, although this result was not constant during the 3-month intervention.
Conclusion: Tango interventions showed efficacy in improving gait and functional mobility, as well as in attenuating the deterioration in capacities of ADL skills. Allowing older people with dementia access to non-pharmacological interventions may be a successful strategy to prevent functional decline.
Trial registration: Tango for Older People with Dementia. Registered at ClinicalTrials.gov (ID: NCT05744011). First trial registration: 24/02/2023
Longitudinal propagation of aquatic disturbances from the largest wildfire recorded in New Mexico, USA
Authors: Nichols Justin , Kaphle Asmita , Tunby Paige , Khandelwal Aashish , Reale Justin , Horn David Van , González-Pinzón Ricardo
Published: July 2023

Wildfires generate hydro-geomorphological disturbances initiated by post-fire precipitation-runoff events. These disturbances are drivers of aquatic impairment over multiple months and years. While the impacts of wildfires on streams and rivers near burned areas have received increased attention in the last decades, it is still unclear how wildfire disturbances propagate longitudinally through fluvial networks. We deployed a rapid response team to install and maintain five high-frequency in-situ sondes to monitor water quality and stream metabolism changes over 190 km along the Gallinas Creek-Pecos River-Santa Rosa Lake fluvial network in response to the Hermit’s Peak - Calf Canyon (HPCC) wildfire, the largest in New Mexico’s recorded history. We assessed how far downstream water quality disturbances propagated along the fluvial network, the role of seasonality in that propagation, and the impact of lakes in mitigating further longitudinal propagation. Monitoring began a few days after the fire started in April 2022 and before any precipitation events had occurred. In the ten months post-fire, there were significant increases in turbidity and fDOM and reductions in gross primary production and ecosystem respiration at all monitoring sites upstream of Santa Rosa Lake. Stream metabolic fingerprints suggest increased scouring, DOC, nutrients, and suspended sediments at these sites. In contrast, the site downstream of Santa Rosa Lake did not have altered turbidity, gross primary production, or ecosystem respiration, and the metabolic fingerprints remained unchanged. These results suggest that Santa Rosa Lake, and associated water operations, buffered the propagation of wildfire disturbances ~180km downstream from the burn scar, resetting water quality parameters and metabolic activity for over ten months post-fire.
Ofatumumab as Part of Reduced Intensity Conditioning in High Risk B-cell Lymphoma Patients: Final Long-term Analysis From a Prospective Multicenter Phase-ii Trial
Authors: Cabrero Mónica , Corral Lucía López , Jarque Isidro , Cruz Fátima de la , Valcárcel David , Pérez Estefanía , Orti Guillermo , Martín Carmen , Caballer Jaime Sanz , Serna Javier de la , Espigado-Tocino Ildefonso , Caballero Maria Dolores
Published: July 2023

Curative potential of allogeneic transplantation (AlloSCT) in high-risk non-Hodgkin lymphoma (NHL) could be enhanced by the integration of Ofatumumab (OFA), a 2nd generation anti-CD20 moAb, due to an antitumor effect and a role over graft-versus-host disease (GVHD). In this phase II trial (NCT01613300), we investigated safety and effectiveness of OFA-based reduced intensity conditioning (RIC). High-risk B-cell NHL patients with chemorrefractory disease or post-autologous SCT relapse were eligible. OFA was added to a standard RIC regimen. Primary endpoint was grade 3–4 aGVHD rate, while secondary endpoints included CR and survival rates. Thirty-three patients were included (median age 51; diffuse large B-cell:68%, HLA-identical donor: 74%). No grade > 2 OFA toxicity was observed. Acute GVHD affected 77% of patients (16% grade 3–4). Remarkably, 75% achieved CR after first-line treatment. Chronic GVHD, primarily mild or moderate, occurred in 54% of patients. The CR rate at day + 100 was 81%. Relapses occurred in 7 patients after a median of 3 months. Causes of death were lymphoma progression (5), infections (10), and GVHD (2). At 24 months, progression-free and overall survival rates were 50%. OFA-RIC regimen is safe and effective, though acute GVHD remains a significant complication. However, data suggest that OFA could mitigate its severity.
Prevalence of patient-reported perioperative anaesthesia-related anxiety, anxiety triggers and its association with patient satisfaction: a retrospective, observational study in Switzerland
Authors: Bello Corina , Nuebling Matthias , Koster Kira-Lee , Heidegger Thomas
Published: July 2023

Perioperative anxiety is a widespread complaint. The mutual relation between anxiety and patient satisfaction with anaesthesia is still under debate. We assessed the prevalence and different triggers of perioperative anxiety and the association with patient satisfaction. A psychometric questionnaire1 was sent to patients after discharge. Clinical Data was used from a previous study. Statistical analysis included bivariate and multivariate regression models. 141 patients (30%) reported anxiety regarding anaesthesia before admission to hospital. The prevalence of anxiety was significantly associated with patient age < 54 years (n = 196, prevalence = 37%, p = 0.002), female gender (n = 242, prevalence 39%, p < 0.001) and surgical specialty (gynaecology (n = 61, prevalence = 49%), otolaryngology (n = 56, prevalence = 46%) p < 0.001). The fear of not waking up from anaesthesia (n = 44, prevalence 32%, SD 45.8) and of developing postoperative nausea or vomiting (n = 42, prevalence 30%, SD 46.0) were the most reported triggers of anxiety. The presence of anxiety was associated with impaired overall patient satisfaction (mean dissatisfaction score 23%, SD 16.3, p < 0.001), especially regarding the dimensions “information and involvement in decision-making” (14% of deficits stated in non-anxious group compared to 23% in anxious group, p < 0.001), “respect and trust” (2% vs 6.26%, p < 0.001) and “continuity of care” (50% vs 57%, p < 0.015).
Sign Language Recognition and Training Module
Authors: V Anjana Devi , T Charulatha , P Dharishinie
Published: July 2023

Recognition of sign language has long been essential to communication between the deaf and non-verbal cultures. From early electric signal-based sign language identification to more recent recognition using machine/deep learning techniques, researchers from all over the world have made an effort to automate this process. Key point detection-based sign language recognition (SLR) is the major goal of this study. The focus of this work is American Sign Language (ASL), particularly ASL pickle data. Several machines learning algorithms, including random forest, support vector machine, and k nearest neighbour, were used to train the model. Lastly, the best model is selected from the model testing using assessment parameters including f1score, precision, and recall. To gather user input, a simple GUI is made, and the forecast is then made using the best machine learning model. Additionally, a training tool for learning American sign language has been developed, which will have a significant impact on non-verbal cultures.
Complex interventions and service innovations: development and application of the COMPLETE framework for patient-centered and justice-oriented design
Authors: May Carl R , Hillis Alyson , Gravenhorst Katja , Bradley Cory D , Geng Elvin , Gallacher Katie , Chew-Graham Carolyn A , Lippiett Kate , May Christine M , Smyth Rachel , Stevenson Fiona , Richardson Alison , Mair Frances , MacFarlane Anne , Montori Victor M
Published: July 2023

Background. The field of implementation research has recently seen considerable, and long overdue, interest in equity, with a strong emphasis on recognizing and responding to disparities in care. The COMPLETE (COMPLEx inTErventions and service innovation)framework is intended to support inclusive intervention and service design. The aim is the development of a patient-centered and justice-informed framework for the design of complex healthcare interventions and innovations in service design.Methods. We undertook three studies. (1) We operationalized constructs from sociological theories of inequality, implementation processes, social roles and expectations, to build a Matrix Model of mechanisms that drive the embedding of disparities in complex healthcare interventions and service innovations. (2) We developed patient-centered and justice-informed principles for design that form a Theory of Change that can be applied in intervention and service design. (3) We then linked the Matrix Model and the Theory of Change together with core elements of theories of prefigurative design and research justice, to build a Transformational Design Cycle for complex interventions and service innovations around a set of critical questions about the implications.Results. The COMPLETE framework focuses on the ways health inequalities and inequities are brought into being by systemic mechanisms within health services; are then propagated and normalized through implementation mechanisms; and are then realized and normalized in practice through institutionalized expectations of patients and caregivers. The framework provides tools to resist the naturalization of inequities and inequalities.Conclusion. We developed a framework for intervention and service design that consists of three components: a conceptual model of the translation of social determinants of health through organizational mechanisms that shape patient and caregivers’ lived experience of disparities in health and healthcare; a transformational theory of change; and a set of principles for design that seeks to place restitution for disparities at its center.
Fading SARS-CoV-2 humoral VOC cross-reactivity versus sustained cellular immunity in convalescent children and adolescents
Authors: Paniskaki Krystallenia , Goretzki Sarah , Anft Moritz , Konik Margarethe J. , Lechtenberg Klara , Vogl Melanie , Meister Toni L. , Pfaender Stephanie , Zettler Markus , Jäger Jasmin , Dolff Sebastian , Westhoff Timm H. , Rohn Hana , Felderhoff-Mueser Ursula , Stervbo Ulrik , Witzke Oliver , Dohna-schwake Christian , Babel Nina
Published: July 2023

Cross-reactive cellular and humoral immunity can substantially contribute to antiviral defense against SARS-CoV-2 variants of concern (VOC). While the adult SARS-CoV-2 cellular and humoral immunity and its cross-recognition potential against VOC is broadly analyzed, similar data regarding the pediatric population are missing. In this study, we perform an analysis of the humoral and cellular SARS-CoV-2 response immune of 32 convalescent COVID-19 children (children), 27 convalescent vaccinated adults(C+V+) and 7 unvaccinated convalescent adults (C+V-). SARS-CoV-2 reactive T cell response is analyzed via multiparametric flowcytometry and humoral immunity is addressed via pseudovirus neutralization assay. Similarly to adults, a significant reduction of cross-reactive neutralizing capacity against delta and omicron VOC was observed 6 months after SARS-CoV-2 infection. While SAR-CoV-2 neutralizing capacity was comparable among children and C+V- against all VOC, children demonstrated as expected an inferior humoral response when compared to C+V+. Nevertheless, children generated SARS-CoV-2 reactive T cells with broad cross-recognition potential. When compared to V+C+, children presented even comparable frequencies of WT-reactive CD4+ and CD8+ T cells with high avidity. Our results suggest that following SARS-CoV-2 infection children generate a humoral SARS-CoV-2 response with neutralizing potential comparable to unvaccinated COVID-19 convalescent adults as well a sustained SARS-CoV-2 cellular response cross-reactive to VOC.
Key statement
Following SARS-CoV-2 infection children generate a humoral SARS-CoV-2 response with neutralizing potential comparable to unvaccinated COVID-19 convalescent adults as well a sustained robust SARS-CoV-2 cellular response cross-reactive to VOC, comparable to vaccinated convalescent adults.