bluuebunny/crossref_metadata_2025 huggingface dataset:
BIM divide: an international comparative analysis of perceived barriers to implementation of BIM in the construction industry
Authors: Saka Abdullahi Babatunde , Chan Daniel W.M.
Published: October 2021

Purpose

Building information modelling (BIM) research studies are highly contextual as the contexts provide lenses for interpreting the results. However, there has been a growing decontextualization in extant studies especially between the small and medium-sized enterprises (SMEs) and large firms; and between developed and developing countries. Albeit these contexts are all in the same construction industry, they often react differently to the same conditions. Thus, this study aims to evaluate the perceptions of firms in varying contexts of size and location on the perceived barriers to the implementation of BIM in the architecture, engineering and construction (AEC) industry.

Design/methodology/approach

The perceptions of 228 firms gleaned from 26 countries across the 6 continents were collated via an international empirical questionnaire survey. The data was analysed using the mean score, rank agreement analysis, Mann-Whitney U test and factor analysis.

Findings

The findings revealed the major factors impending BIM implementation in each of the contexts and a comparative analysis emphasized the difference in their perceptions. The findings underscore that there is a general digital divide as regard BIM implementation between the SMEs and large firms, and a deepening divide between the developed and developing countries.

Originality/value

The study has provided empirical evidence for the BIM divide in the AEC industry, which would influence the promulgation of BIM policy and transferability of best practices across varying contexts of both firm size and country level.
Latent classes of accounting outsourcing firms
Authors: Juntunen Jouni , Lepistö Sinikka , Juntunen Mari
Published: October 2021

Purpose

Outsourcing of accounting increasingly attracts research interest, but research concerning the impact of the benefits of outsourcing on firm capabilities and performance across firms remains limited. This paper aims to reveal the unobservable latent classes of firms that outsource their accounting functions by testing a research model concerning the topic.

Design/methodology/approach

The authors build on accounting outsourcing research and adapt a research model from the literature on business services outsourcing. The authors analyze the data from 261 small and medium-sized enterprises in Europe using finite mixture structural equation modeling (FMSEM) and additional methods.

Findings

The authors reveal three latent classes with different research models. Thriving outsourcers (N = 103) have a positive attitude toward accounting outsourcing and associate competitive capabilities with mediating the relationship from outsourcing benefits to firm performance. Annoyed outsourcers (N = 143) are dissatisfied with their accounting service provider and only associate outsourcing benefits with competitive capabilities. Convenient outsourcers (N = 15) feel comfortable with their current accounting service provider and associate outsourcing benefits with neither capabilities nor with firm performance.

Research limitations/implications

The study initiates the discussion about the unobservable heterogeneity among accounting outsourcers. The study introduces the use of the FMSEM method in accounting outsourcing research.

Practical implications

The study offers novel insights concerning accounting outsourcers and proposes original explanations for their outsourcing decisions that would help both the outsourcers and accounting service providers.

Originality/value

The study might be the first to categorize accounting outsourcers using FMSEM.
Customer’s awareness, trust, discomfort and acceptance of anti-money laundering practices in Malaysian Banks
Authors: Azman Aziz Zuliera Zariz , Md Daud Seri Ayu Masuri
Published: October 2021

Purpose

This study aims to examine the associations between customers’ awareness of money laundering and terrorism financing, trust in banking secrecy measures and discomforts in fulfilling the bank’s anti-money laundering (AML) procedure and their acceptance of existing practices of banks regarding AML and counter-terrorism financing.

Design/methodology/approach

This study adapts a set of survey instruments developed and validated by prior studies to collect the required data. A convenient sample of 160 Malaysian bank customers aged 18 and above were surveyed to collect the data.

Findings

This study finds a significant relationship between the respondents’ awareness of money laundering and terrorism financing, trust in banking secrecy measures and their acceptance of the bank’s AML and counter-terrorism financing practices. However, no significant relationship is documented between the level of discomforts experienced by customers in satisfying the banks’ AML requirements and their acceptance of the banks’ AML practices. These results hold even after controlling for alternative explanations of the customers’ acceptance of banking practices examined in the extant literature: age, gender, location, literacy level and occupation.

Research limitations/implications

This study extends the literature on customers’ acceptance of banking practices more broadly by providing empirical evidence on the role of customers’ awareness on issues underlying the banking practices and their trust in the bank’s secrecy measures.

Practical implications

This study also provides some practical contributions by shedding some light on the factors that could help banks increase the acceptance of AML practices among their customers. Thus, the findings of this paper help banks focus their effort on these factors and hence increase acceptance rate more effectively.

Originality/value

Drawing on the elements of the theory of reasoned actions and technology acceptance model and the extant research on trust-privacy and comfortability in a banking setting, this study proposes an integrated approach that is theoretically and empirically grounded.
Assessment of the European monitoring frameworks for circular economy: the case of Croatia
Authors: Švarc Jadranka , Dabić Marina , Lažnjak Jasminka
Published: October 2021

Purpose

The main purpose of this research is to analyse the efficiency of the main European monitoring frameworks to estimate the transition of the countries within the European Union (EU) towards circular economy (CE) using the example of Croatia.

Design/methodology/approach

Assessment methods with reliable data and appropriate indicators are essential when it comes to measuring transition and progress towards CE. The methodology employed in this research is a systematic and critical analysis of the seven European measurement frameworks employed to assess Croatia's progress towards CE.

Findings

The analysis revealed how EU's monitoring frameworks have developed over time and how useful they are in evaluating country's progress towards CE. The measurement tools and indicators proved, in the case of Croatia, insufficient for clarifying and understanding its progress towards CE. Selection of indicators within monitoring frameworks is arbitrary while their interpretation is highly contextual, dependent on policy targets and local conditions. These results can be extrapolated to other EU member states.

Practical implications

Policy recommendations for more efficient CE transitions are provided.

Originality/value

This research sheds light on the CE development in Croatia – an understudied European country in this context – and discusses the country's goals towards sustainability. The limited success of developed CE indicators is discussed.
Relationships between method-section citation rates and citation contexts: evidence from highly cited references in psychology
Authors: Li Kai
Published: October 2021

Purpose

The Method section of research articles offers an important space for researchers to describe their research processes and research objects they utilize. To understand the relationship between these research materials and their representations in scientific publications, this paper offers a quantitative examination of the citation contexts of the most frequently cited references in the Method section of the paper sample, many of which belong to the category of research material objects.

Design/methodology/approach

In this research, the authors assessed the extent to which these references appear in the Method section, which is regarded as an indicator of the instrumentality of the reference. The authors also examined how this central measurement is connected to its other citation contexts, such as key linguistic attributes and verbs that are used in citation sentences.

Findings

The authors found that a series of key linguistic attributes can be used to predict the instrumentality of a reference. The use of self-mention phrases and the readability score of the citances are especially strong predictors, along with boosters and hedges, the two measurements that were not included in the final model.

Research limitations/implications

This research focuses on a single research domain, psychology, which limits the understanding of how research material objects are cited in different research domains or interdisciplinary research contexts. Moreover, this research is based on 200 frequently cited references, which are unable to represent all references cited in psychological publications.

Practical implications

With the identified relationship between instrumental citation contexts and other characteristics of citation sentences, this research opens the possibility of more accurately identifying research material objects from scientific references, the most accessible scholarly data.

Originality/value

This is the first large-scale, quantitative analysis of the linguistic features of citations to research material objects. This study offers important baseline results for future studies focusing on scientific instruments, an increasingly important type of object involved in scientific research.

Peer review

The peer review history for this article is available at: 10.1108/OIR-03-2021-0171
Determinants of recycling behavior in higher education institution
Authors: Thoo Ai Chin , Tee Shi Jie , Huam Hon Tat , Mas’od Adaviah
Published: October 2021

Purpose

This study aims to investigate the impact of theory of planned behavior (namely, attitude, subjective norm and perceived behavioral control) on recycling intention, as well as the relationship between recycling intention and behavior in one of the top five universities in Malaysia. In addition, the mediation effect of recycling intention on the relationships is investigated.

Design/methodology/approach

A total of 180 responses were collected using online survey that distributed via Google Form. SmartPLS was used for data analysis via outer and inner model assessment. The assessments include construct reliability, validity and hypotheses testing.

Findings

The findings indicated that attitude, subjective norm and perceived behavioral control have a positive and significant relationship with students’ recycling intention. Besides, students’ recycling intention is positively related to actual recycling behavior. Additionally, this study also discovered that recycling intention mediates the relationship between attitude and recycling behavior, between subjective norm and recycling behavior, as well as between perceived behavioral control and recycling behavior.

Practical implications

The result of the study may serve as a guide for universities or higher education institutions to design effective recycling campaigns to promote the campus sustainability.

Originality/value

Universities are in a crucial position to make a huge impact when they recycle. In Malaysia, there is still a lack of high concern of universities toward green and sustainability concept. This paper fulfils the gap to study how recycling behavior can be enabled.
Seed viability in Bursera: The relative contribution of environmental variation and phylogenetic relatedness
Authors: Mendoza‐Segovia Yazmín Anaín , Zúñiga‐Vega José Jaime , Bonfil Consuelo
Published: October 2021

Seed viability is a crucial factor affecting the regeneration potential of seeds, but there is little information on how this trait varies across habitats, populations, species, and higher taxonomic units, as well as on the relative contributions of evolutionary history and environmental factors to this trait. Here we evaluate the relative contributions of climatic variability and phylogenetic history to seed viability in a group of species of Bursera that belong to two distinct lineages (sections Bursera and Bullockia). We analyzed 39 seed lots from 11 species, comprising several populations and 2 years, and estimated embryo presence and viability in each lot. We examined spatial and temporal variation in viability and analyzed the relationship between this trait and water availability using regression models; the amount of phylogenetic signal in seed viability was also estimated. Mean seed viability was consistently low in species of section Bursera (mean 29.7%) and substantially higher in species of section Bullockia (mean 79.6%). A high proportion of unviable seeds were embryoless. Spatial and temporal variation in seed viability was significant but usually low among populations and species. The relationship between water availability and seed viability was not significant, but the amount of phylogenetic signal in seed viability was high and significant (λ = 0.74). There is a clear difference in seed viability among the two sections of Bursera. During the split of the two sections in the middle Eocene, the reorganization of the genome may have involved changes in fruit morphology associated with differences in parthenocarpy among them.
Increased paediatric emergency mental health and suicidality presentations duringCOVID‐19 stay at home restrictions
Authors: Carison Anna , Babl Franz E , O'Donnell Sinead M
Published: October 2021

Objective

Anecdotal reports indicate an increase in mental health presentations and acuity to EDs during the COVID‐19 pandemic and associated stay at home restrictions. Paediatric and adolescent data to confirm this are unavailable in the Australian setting.

Methods

Retrospective electronic medical record review of all ED patients with mental health discharge codes at a large tertiary children's hospital in Australia during the period of stay at home restrictions from 1 April to 30 September 2020 compared with the same dates in 2019.

Results

We found a 40% decrease in ED presentations (18 935–11 235) with a concurrent 47% increase in mental health presentations (809–1190) to ED during the study periods between 2019 and 2020. This resulted in an increase of 100 mental health admissions from ED. Diagnoses with greatest percentage increases were eating disorders, social issues and suicidality. We found suicidality presentation numbers were highest in June to September 2020 compared with 2019. Patients with a diagnosis of suicidality had a higher rate of re‐presentation in 2020 (1.83 presentations per patient) compared to 2019 (1.38 presentations per patient).

Conclusions

Despite an overall decrease in ED presentations, the absolute increase in mental health presentations for children and adolescents during the stay at home restriction period was pronounced. It is unclear how sustained this change and the impact on mental health resource use will be post‐pandemic.
Cross‐cultural adaptation for Brazil and validity of a guide to assist nursing students’ clinical reasoning
Authors: Guandalini Lidia Santiago , Santos Vinicius Batista , Tesoro Mary Gay , Maurício Aline Batista , Drehmer de Almeida Cruz Elaine , de Lima Lopes Juliana , Lopes Camila Takao , Bottura Leite de Barros Alba Lucia
Published: October 2021

Purpose

To assess the validity of a Written Clinical Reasoning Prompt (WCRP) to help nursing students’ clinical reasoning (CR).

Method

This is a methodological study of translation and cross‐cultural adaptation into Brazilian Portuguese of instruments that aim to promote CR improvement, composed of (1) WCRP; (2) two case studies; (3) a questionnaire about students’ perceptions during decision‐making in case studies; (4) a scoring rubric for correcting case studies. For translation and cross‐cultural adaptation, stages 1–8 of the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) Consortium Network were adopted. Agreement values among experts >80% and content validity coefficient (CVC) > 0.8 were considered satisfactory. For the pretest, a randomized clinical trial was carried out with 24 nursing students (intervention group, n = 14, using the WCRP to solve case studies; control group, n = 10, without using the WCRP).

Findings

The WCRP was translated and adapted into Brazilian Portuguese, requiring minimal adjustments to obtain agreement among the judges above 80% and CVC above 0.80. Regarding face validation, an adequate agreement was obtained in the assessment by students. There was no difference in the accuracy of nursing diagnoses between the intervention and control groups in the pretest.

Conclusion

The WCRP was translated and adapted into Brazilian Portuguese and had adequate face and content validity estimates; however, there was no association with improving nursing students’ diagnostic accuracy.

Implications for nursing practice

The translated and adapted versions of all instruments into Brazilian Portuguese had adequate evidence of content and face validity. The use of WCRP was not associated with a significant improvement in nursing students’ diagnostic accuracy. New studies with larger samples, a sample power of at least 80%, and a level of significance of 5% are needed.
Effects of glaucoma surgery on visual field progression in open‐angle glaucoma considering the floor effect
Authors: Schlatter Andreas , Rauchegger Teresa , Schmid Eduard , Teuchner Barbara
Published: October 2021

Purpose

The aim of this retrospective analysis was to investigate whether trabeculectomy (TRAB) and XEN® Gel Stent implantation (XEN) – both filtrating surgery techniques – can slow down the deterioration of visual field (VF) parameters considering the floor effect, which could lead to a misestimation of pre‐ and postoperative VF rate of progression (ROP).

Methods

Included in this study were patients with open‐angle glaucoma, who underwent either TRAB or XEN® gel stent implantation and who had at least three VF tests before and after surgery, over an observation period of 13 years. The annual ROP of the mean defect (MD) and the square root of loss variance (sLV) were calculated with two different censoring thresholds: by censored regression and by ordinary least squares regression (OLSR). In addition, the diagnostic range of sLV was calculated.

Results

48 eyes of 39 glaucoma patients were included in the study. The annual rate of MD progression was significantly reduced by filtering surgery when calculating the yearly ROP using OLSR (p = 0.006) and by censoring values exceeding a precalculated cut‐off of 14.20 dB (p = 0.041) and a cut‐off from the literature of 15.00 dB (p = 0.028). On average, the MD was impacted by a significant floor effect of 14.20 dB (95% CI: 12.83‐15.56), corresponding to 17.7/59 absolute defects or 29.9% of the whole VF. When applying both OLSR and censored regression, the annual rate of sLV progression did not show a significant difference. The sLV showed a diagnostic boundary at a MD of 15.78 dB.

Conclusion

This study shows that filtering surgery can reduce the progression of VF in patients with open‐angle glaucoma, especially those whose disease develops aggressively. This is valid even if the floor effect in advanced cases is compensated by censored regression. On average, the ROP of MD is affected by a significant floor effect at about 29.9% absolute loss of the whole VF.
Performance of creatinine‐based equations to estimate glomerular filtration rate with a methodology adapted to the context of drug dosage adjustment
Authors: Delanaye Pierre , Björk Jonas , Courbebaisse Marie , Couzi Lionel , Ebert Natalie , Eriksen Björn O. , Dalton R. Neil , Dubourg Laurence , Gaillard Francois , Garrouste Cyril , Grubb Anders , Jacquemont Lola , Hansson Magnus , Kamar Nassim , Lamb Edmund J. , Legendre Christophe , Littmann Karin , Mariat Christophe , Melsom Toralf , Rostaing Lionel , Rule Andrew D. , Schaeffner Elke , Sundin Per‐Ola , Berg Ulla B. , Åsling‐Monemi Kajsa , Selistre Luciano , Åkesson Anna , Larsson Anders , Bökenkamp Arend , Pottel Hans , Nyman Ulf
Published: October 2021

Aim

The Cockcroft‐Gault (CG) creatinine‐based equation is still used to estimate glomerular filtration rate (eGFR) for drug dosage adjustment. Incorrect eGFR may lead to hazardous over‐ or underdosing.

Methods

In a cross‐sectional analysis, CG was validated against measured GFR (mGFR) in 14 804 participants and compared with the Modification‐of‐Diet‐in‐Renal‐Diseases (MDRD), Chronic‐Kidney‐Disease‐Epidemiology (CKD‐EPI), Lund‐Malmö‐Revised (LMR) and European‐Kidney‐Function‐Consortium (EKFC) equations. Validation focused on bias, imprecision and accuracy (percentage of estimates within ±30% of mGFR, P30), overall and stratified for mGFR, age and body mass index at mGFR <60 mL/min, as well as classification in mGFR stages.

Results

The CG equation performed worse than the other equations, overall and in mGFR, age and BMI subgroups in terms of bias (systematic overestimation), imprecision and accuracy except for patients ≥65 years where bias and P30 were similar to MDRD and CKD‐EPI, but worse than LMR and EKFC. In subjects with mGFR <60 mL/min and at BMI 18.5‐25 kg/m2, all equations performed similarly, and for BMI < 18.5 kg/m2 CG and LMR had the best results though all equations had poor P30‐accuracy. At BMI ≥ 25 kg/m2 the bias of the CG increased with increasing BMI (+17.2 mL/min at BMI ≥ 40 kg/m2). The four more recent equations also classified mGFR stages better than CG.

Conclusions

The CG equation showed poor ability to estimate GFR overall and in analyses stratified for mGFR, age and BMI. CG was inferior to correctly classify the patients in the mGFR staging compared to more recent creatinine‐based equations.
Exploring the intellectual structure of research in codes of ethics: A bibliometric analysis
Authors: Delgado‐Alemany Rafael , Blanco‐González Alicia , Díez‐Martín Francisco
Published: October 2021

In this study, we map the intellectual structure of the code of ethics research field by means of a co‐citation bibliometric analysis. To date, this type of analysis is absent from the literature on codes of ethics. Previous literature reviews have clarified definitions, studied contents, and analyzed the effectiveness of codes of ethics. However, the qualitative nature of these reviews does not resolve fundamental issues for understanding the evolution and status of this research field. This study contributes to the field by providing a bibliometric review in which the main research areas, sources of knowledge, trends, interrelationships, and dissemination paths of the domain are shown. Our findings reveal four main lines of research in the field of codes of ethics: corporate agent behavior with respect to codes of ethics, content analysis, effectiveness of codes of ethics, and employees’ attitudes toward codes of ethics. We also show that the study of the contents of codes of ethics is the main connecting bridge in this area of knowledge. Finally, we identify upcoming research topics in the field such as cultural change, the defensive nature of codes of ethics, and the application of organizational theories to code analysis.
Relationship between physical activity and health in individuals with intellectual disability
Authors: Faust Caroline , Morin Diane
Published: October 2021

Accessible summary

Individuals with intellectual disability are less physically active and have more health problems than the general population.

This paper is about information gathered from family members on health and physical activity levels of people with intellectual disability.

Health of people with intellectual disability do not differ according to the frequency and the intensity of physical activity.

Research is important for people with intellectual disability because our results helped better understand the need for developing physical activity guidelines specifically for this population and strategies to encourage them to be more physically active.

Background

The frequency and intensity of physical activity are directly related to health in the general population. However, to our knowledge, no study has looked at that relationship in people with intellectual disability.

Method

The aim of this study was to determine whether there were differences in the health of 407 people with intellectual disability according to the frequency and intensity of physical activity. The method involved cross‐sectional study of secondary data.

Findings

Results showed that the ability to express pain, number of orthopaedic and physiotherapy consultations, body mass index and percentage of psychosis/schizophrenia diagnoses differed with the frequency and intensity of physical activity.

Conclusion

Other studies are needed to learn more about physical activity factors that could improve the health of people with intellectual disability.
Clinical, neuropathological, and immunological short‐ and long‐term feature of a mouse model mimicking human herpes virus encephalitis
Authors: Sehl‐Ewert Julia , Schwaiger Theresa , Schäfer Alexander , Hölper Julia E. , Klupp Barbara G. , Teifke Jens P. , Blohm Ulrike , Mettenleiter Thomas C.
Published: October 2021

Herpes simplex encephalitis (HSE) is one of the most serious diseases of the nervous system in humans. However, its pathogenesis is still only poorly understood. Although several mouse models of predominantly herpes simplex virus 1 (HSV‐1) infections mimic different crucial aspects of HSE, central questions remain unanswered. They comprise the specific temporofrontal tropism, viral spread within the central nervous system (CNS), as well as potential molecular and immunological barriers that drive virus into latency while only rarely resulting in severe HSE. We have recently proposed an alternative mouse model by using a pseudorabies virus (PrV) mutant that more faithfully represents the striking features of human HSE: temporofrontal meningoencephalitis with few severely, but generally only moderately to subclinically affected mice as well as characteristic behavioral abnormalities. Here, we characterized this animal model using 6‐ to 8‐week‐old female CD‐1 mice in more detail. Long‐term investigation over 6 months consistently revealed a biphasic course of infection accompanied by recurring clinical signs including behavioral alterations and mainly mild meningoencephalitis restricted to the temporal and frontal lobes. By histopathological and immunological analyses, we followed the kinetics and spatial distribution of inflammatory lesions as well as the underlying cytokine expression in the CNS over 21 days within the acute phase of infection. Affecting the temporal lobes, the inflammatory infiltrate was composed of lymphocytes and macrophages showing a predominantly lymphocytic shift 15 days after infection. A strong increase was observed in cytokines CXCL10, CCL2, CCL5, and CXCL1 recruiting inflammatory cells to the CNS. Unlike the majority of infected mice, strongly affected animals demonstrated extensive temporal lobe edema, which is typically present in severe human HSE cases. In summary, these results support the validity of our animal model for in‐depth investigation of HSE pathogenesis.
Identification of RET fusions in a Chinese multicancer retrospective analysis by next‐generation sequencing
Authors: Shi Minke , Wang Weiran , Zhang Jinku , Li Bobo , Lv Dongxiao , Wang Danhua , Wang Sizhen , Cheng Dezhi , Ma Tonghui
Published: October 2021

Fusion of RET with different partner genes has been detected in papillary thyroid, lung, colorectal, pancreatic, and breast cancer. Approval of selpercatinib for treatment of lung and thyroid cancer with RET gene mutations or fusions calls for studies to explore RET fusion partners and their eligibility for RET‐based targeted therapy. In this study, RET fusion patterns in a large group of Chinese cancer patients covering several cancer types were identified using next‑generation sequencing. A total of 44 fusion patterns were identified in the study cohort with KIF5B, CCDC6, and ERC1 being the most common RET fusion partners. Notably, 17 novel fusions were first reported in this study. Prevalence of functional RET fusions was 1.05% in lung cancer, 6.03% in thyroid cancer, 0.39% in colorectal cancer, and less than 0.1% in gastric cancer and hepatocellular carcinoma. Analysis showed a preference for fusion partners in different tumor types, with KIF5B being the common type in lung cancer, CCDC6 in thyroid cancer, and NCOA4 in colorectal cancer. Co‐occurrence of EGFR mutations and RET fusions with rare partner genes (rather than KIF5B) in lung cancer patients was correlated with epidermal growth factor receptor‐tyrosine kinase inhibitor resistance and could predict response to targeted therapies. Findings from this study provide a guide to clinicians in determining tumors with specific fusion patterns as candidates for RET targeted therapies.
Infant vocalizing and phenotypic outcomes in autism: Evidence from the first 2 years
Authors: Plate Samantha , Yankowitz Lisa , Resorla Leslie , Swanson Meghan R. , Meera Shoba Sreenath , Estes Annette , Marrus Natasha , Cola Meredith , Petrulla Victoria , Faggen Aubrey , Pandey Juhi , Paterson Sarah , Pruett John R. , Hazlett Heather , Dager Stephen , St. John Tanya , Botteron Kelly , Zwaigenbaum Lonnie , Piven Joseph , Schultz Robert T. , Parish‐Morris Julia ,   IBIS Network
Published: October 2021

Infant vocalizations are early‐emerging communicative markers shown to be atypical in autism spectrum disorder (ASD), but few longitudinal, prospective studies exist. In this study, 23,850 infant vocalizations from infants at low (LR)‐ and high (HR)‐risk for ASD (HR‐ASD = 23, female = 3; HR‐Neg = 35, female = 13; LR = 32, female = 10; 80% White; collected from 2007 to 2017 near Philadelphia) were analyzed at 6, 12, and 24 months. At 12 months, HR‐ASD infants produced fewer vocalizations than HR‐Neg infants. From 6 to 24 months, HR‐Neg infants demonstrated steeper vocalization growth compared to HR‐ASD and LR infants. Finally, among HR infants, vocalizing at 12 months was associated with language, social phenotype, and diagnosis at age 2. Infant vocalizing is an objective behavioral marker that could facilitate earlier detection of ASD.
Mono‐allelic loss of YTHDF3 and neurodevelopmental disorder: clinical features of four individuals with 8q12.3 deletions
Authors: Terkelsen Thorkild , Brasch‐Andersen Charlotte , Illum Niels , Busa Tiffany , Missirian Chantal , Chandler Kate , Holden Simon T. , Jensen Uffe Birk , Fagerberg Christina R.
Published: October 2021

The YTH domain family member 3 gene (YTHDF3) encodes a reader of the abundant N6‐methyladenosine (m6A) modification of eukaryotic mRNA, which plays an essential role in regulating mRNA stability and is necessary to achieve normal development of the central nervous system in animal models. YTHDF3 has not previously been implicated in Mendelian disease despite a high probability of loss of function intolerance and statistical evidence of enrichment for gene‐disruptive de novo variants in large‐scale studies of individuals with intellectual disability and/or developmental delay. We report four individuals with deletion of 8q12.3, deletion size 1.38–2.60 Mb, encompassing YTHDF3, three of them were de novo, and in one case, the inheritance was unknown. Common features of the individuals (age range, 4–22 years) were developmental delay and/or intellectual disability. Two individuals underwent squint surgery. We suggest that haploinsufficiency of YTHDF3 causes a neurodevelopmental disorder with developmental delay and intellectual disability of variable degree.
Phylogeny of gracillariid leaf‐mining moths: evolution of larval behaviour inferred from phylogenomic and Sanger data
Authors: Li Xuankun , St Laurent Ryan , Earl Chandra , Doorenweerd Camiel , van Nieukerken Erik J. , Davis Donald R. , Johns Chris A. , Kawakita Atsushi , Kobayashi Shigeki , Zwick Andreas , Lopez‐Vaamonde Carlos , Ohshima Issei , Kawahara Akito Y.
Published: October 2021

Gracillariidae is the most taxonomically diverse cosmopolitan leaf‐mining moth family, consisting of nearly 2000 named species in 105 described genera, classified into eight extant subfamilies. The majority of gracillariid species are internal plant feeders as larvae, creating mines and galls in plant tissue. Despite their diversity and ecological adaptations, their phylogenetic relationships, especially among subfamilies, remain uncertain. Genomic data (83 taxa, 589 loci) were integrated with Sanger data (130 taxa, 22 loci), to reconstruct a phylogeny of Gracillariidae. Based on analyses of both datasets combined and analyzed separately, monophyly of Gracillariidae and all its subfamilies, monophyly of the clade “LAMPO” (subfamilies: Lithocolletinae, Acrocercopinae, Marmarinae, Phyllocnistinae, and Oecophyllembiinae) and relationships of its subclade “AMO” (subfamilies: Acrocercopinae, Marmarinae, and Oecophyllembiinae) were strongly supported. A sister‐group relationship of Ornixolinae to the remainder of the family, and a monophyletic leaf roller lineage (Callicercops Vári + Parornichinae) + Gracillariinae, as sister to the “LAMPO” clade were supported by the most likely tree. Dating analyses indicate a mid‐Cretaceous (105.3 Ma) origin of the family, followed by a rapid diversification into the nine subfamilies predating the Cretaceous–Palaeogene extinction. We hypothesize that advanced larval behaviours, such as making keeled or tentiform blotch mines, rolling leaves and galling, allowed gracillariids to better avoid larval parasitoids allowing them to further diversify. Finally, we stabilize the classification by formally re‐establishing the subfamily ranks of Marmarinae stat.rev., Oecophyllembiinae stat.rev. and Parornichinae stat.rev., and erect a new subfamily, Callicercopinae Li, Ohshima and Kawahara to accommodate the enigmatic genus Callicercops.
‘When I open it, I have to drink it all’: Push and pull factors shaping domestic alcohol consumption during the COVID‐19 pandemic UK Spring 2020 lockdown
Authors: Conroy Dominic , Nicholls Emily
Published: October 2021

Introduction

The closure of licensed venues during the COVID‐19 pandemic meant that most alcohol has been consumed at home during lockdown periods in the UK, a phenomenon that remains under‐researched despite the public health implications.

Methods

This article draws on a study consisting of online semi‐structured interviews and focus groups with 20 UK drinkers, conducted between the first and second 2020 UK lockdowns. The study aimed to explore changing and enduring UK drinking practices within home spaces during the pandemic.

Results

Our findings illuminate specific ways in which assemblages and contextual factors may come together to encourage or mitigate against the consumption of any (or excessive) volumes of alcohol at home during the lockdown. For example, the physical presence of alcohol bottles may both encourage consumption (e.g. compulsion to finish an open bottle of wine) and cue reflection on one's drinking (through the potentially confronting presence of empty bottles after domestic drinking). We also highlight the significance of the home as a space separate from—and different to—public drinking spaces.

Discussion and Conclusions

With the increasing normalisation of domestic drinking during a global pandemic, this paper illuminates several factors that may encourage or curtail domestic alcohol consumption and invites us to consider the importance of assemblages, space and context. Such findings have wider applicability; for example, consideration of specific (and perhaps unique) push and pull factors of home spaces could inform future alcohol policy, health promotion messages and how guidance around ‘moderation’ or risky drinking is communicated.
Sensory stimulation via the visual, auditory, olfactory and gustatory systems can modulate mood and depression
Authors: Canbeyli Resit
Published: October 2021

Depression is one of the most common mental disorders, predicted to be the leading cause of disease burden by the next decade. There is great deal of emphasis on the central origin and potential therapeutics of depression whereby the symptomatology of depression has been interpreted and treated as brain generated dysfunctions filtering down to the periphery. This top‐down approach has found strong support from clinical work and basic neuroscientific research. Nevertheless, despite great advances in our knowledge of the aetiology and therapeutics of depression, success in treatment is still by no means assured. As a consequence, a wide net has been cast by both clinicians and researchers in search of more efficient therapies for mood disorders. As a complementary view, the present integrative review advocates approaching mood and depression from the opposite perspective: a bottom‐up view that starts from the periphery. Specifically, evidence is provided to show that sensory stimulation via the visual, auditory, olfactory, and gustatory systems can modulate depression. The review shows how—depending on several parameters—unisensory stimulation via these modalities can ameliorate or aggravate depressive symptoms. Moreover, the review emphasises the bidirectional relationship between sensory stimulation and depression. Just as peripheral stimulation can modulate depression, depression in turn affects—and in most cases impairs—sensory reception. Furthermore, the review suggests that combined use of multisensory stimulation may have synergistic ameliorative effects on depressive symptoms over and above what has so far been documented for unisensory stimulation.
Low‐salinity transitions drive abrupt microbial response to sea‐level change
Authors: Whittle Alex , Barnett Robert L. , Charman Dan J. , Gallego‐Sala Angela V.
Published: October 2021

The salinisation of many coastal ecosystems is underway and is expected to continue into the future because of sea‐level rise and storm intensification brought about by the changing climate. However, the response of soil microbes to increasing salinity conditions within coastal environments is poorly understood, despite their importance for nutrient cascading, carbon sequestration and wider ecosystem functioning. Here, we demonstrate deterioration in the productivity of a top‐tier microbial group (testate amoebae) with increasing coastal salinity, which we show to be consistent across phylogenetic groups, salinity gradients, environment types and latitude. Our results show that microbial changes occur in the very early stages of marine inundation, presaging more radical changes in soil and ecosystem function and providing an early warning of coastal salinisation that could be used to improve coastal planning and adaptation.
Modified particle swarm optimization based magnetic resonance imaging analysis for identification of risk factors tissue damage incidence
Authors: Ke Ji , Wang Shufa , Li Jiangchun , Liu Quan
Published: October 2021

This study was to analyse the risk factors of unstable patella and the incidence of tissue damage (TD) with magnetic resonance imaging (MRI) image under the modified particle swarm optimization (MPSO). In this study, 45 patients with patella instability who visited hospital from 1 November 2018 to 28 September 2020 were selected as the experimental group (group E), and 45 volunteers with healthy knee joints were recruited as the control group (group C). MRI images under MPSO were to evaluate the four groups of related indicators (trochlear groove angle, trochlear groove depth, trochlear surface ratios, and Insall‐Salvati index) of unstable patella in the two groups and count the incidence of TD caused by unstable patella. Comparison of four indicators revealed that there was an obvious difference in the data of the two groups. The abnormal rate of patients with unstable patella in the group E was much higher than that of the group C, and the difference was statistical (p < 0.05). The incidences of trochlea dysplasia and high patella accounted for 88.9% and 57.8% in group E and accounted for 4.4% and 3.2% in the group C, respectively, showing statistically obvious differences (p < 0.05). The incidence of patella cartilage TD, thigh cartilage TD, lateral meniscus TD, medial meniscus TD, patella medial retinaculum TD, patella lateral retinaculum TD, patellar ligament damage, and joint effusions were 14.5%, 11.45%, 50.38%, 49.62%, 10.69%, 16.03%, 9.16%, and 79.39%, respectively in the patients with unstable patella in the group E. In short, trochlear dysplasia and high patella were risk factors for unstable patella, and unstable patella was one of the risk factors for multiple TDs of the knee joint. This study provided a new research basis for the early treatment of unstable patella.
Surviving death: emerging concepts of RIPK3 and MLKL ubiquitination in the regulation of necroptosis
Authors: Karlowitz Rebekka , van Wijk Sjoerd J. L.
Published: October 2021

Lytic forms of programmed cell death, like necroptosis, are characterised by cell rupture and the release of cellular contents, often provoking inflammatory responses. In the recent years, necroptosis has been shown to play important roles in human diseases like cancer, infections and ischaemia/reperfusion injury. Coordinated interactions between RIPK1, RIPK3 and MLKL lead to the formation of a dedicated death complex called the necrosome that triggers MLKL‐mediated membrane rupture and necroptotic cell death. Necroptotic cell death is tightly controlled by post‐translational modifications, among which especially phosphorylation has been characterised in great detail. Although selective ubiquitination is relatively well‐explored in the early initiation stages of necroptosis, the mechanisms and functional consequences of RIPK3 and MLKL ubiquitination for necrosome function and necroptosis are only starting to emerge. This review provides an overview on how site‐specific ubiquitination of RIPK3 and MLKL regulates, fine‐tunes and reverses the execution of necroptotic cell death.
Low cycle fatigue performance of DP900 steel under cyclic shear paths
Authors: Zhang Zhongran , Yue Zhenming , Qi Jiashuo , Gao Jun , Qiu Yuliang
Published: October 2021

In this study, a sheet fatigue shear test device is designed and applied to the low‐cycle fatigue testing of DP900 with varying strain amplitudes within the range of 0.5%–6.0%. The microstructure is analyzed by using electron backscatter diffraction, and fracture surfaces are examined via scanning electron microscopy. Results indicate that the material exhibits cyclic softening behavior after the first two cycles of hardening, with a stable softening rate and a high damage evolution rate related to loading amplitude. The variation of the hysteresis curve in the cyclic process is shown. Total plastic strain energy absorbed increases as loading amplitude decreases and it reaches the peak at approximately 1%. The life prediction model based on plastic strain energy density and strain amplitude is verified to be suitable for the cyclic shear path. The influence of microinhomogeneity on the distribution of stress and strain, especially the deformation of martensite, is closely related to the bi‐linear region of fatigue life curve.
Investigation of creep damage mechanical behaviors of red sandstone considering temperature effect
Authors: Pan Xiaokang , Berto Filippo , Zhou Xiaoping
Published: October 2021

This work investigates the influence of high temperature on the creep damage behaviors of red sandstone. The closure and evolution of microcracks in the red sandstone treated at different temperatures during the enter creep process are analyzed. Temperature has obvious influence on uniaxial compressive strength, Young's modulus, and failure modes of red sandstone. It can degrade the mechanical behaviors of red sandstone and can reduce the ability of red sandstone to resist creep deformation. Moreover, acoustic emission (AE) technology is employed to monitor the distribution law of the AE events generated at each creep stage. As the temperature increases, the absolute value of the critical index increases exponentially, reflecting the exponential increase in the proportion of its low‐energy AE signal.
Reef‐building corals act as long‐term sink for microplastic
Authors: Reichert Jessica , Arnold Angelina L. , Hammer Nils , Miller Ingo B. , Rades Marvin , Schubert Patrick , Ziegler Maren , Wilke Thomas
Published: October 2021

The pollution of the marine environment with microplastics is pervasive. However, microplastic concentrations in the seawater are lower than the number of particles entering the oceans, suggesting that plastic particles accumulate in environmental sinks. Yet, the exact long‐term sinks related to the “missing plastic” phenomenon are barely explored. Sediments in nearshore biogenic habitats are known to trap large amounts of microplastics, but also the three‐dimensional structures of coral reefs might serve as unique, living long‐term sinks. The main framework builders, reef‐building corals, have been shown to ingest and overgrow microplastics, potentially leading to a deposition of particles in reef structures. However, little is known about the number of deposited particles and the underlying processes determining the permanent deposition in the coral skeletons. To test whether corals may act as living long‐term sink for microplastic, we exposed four reef‐building coral species to polyethylene microplastics (200 particles L−1) in an 18‐month laboratory experiment. We found microplastics in all treatment specimens, with low numbers of particles trapped in the coral tissue (up to 2 particles per cm2) and much higher numbers in the skeleton (up to 84 particles per cm3). The numbers of particles accumulated in the coral skeletons were mainly related to coral growth (i.e., skeletal growth in volume), suggesting that deposition is a regularly occurring stochastic process. We estimate that reef‐building corals may remove 0.09%–2.82% of the bioavailable microplastics from tropical shallow‐reef waters per year. Our study shows for the first time that microplastic particles accumulate permanently in a biological sink, helping to explain the “missing plastic” phenomenon. This highlights the importance of coral reefs for the ecological balance of the oceans and reinforces the need to protect them, not only to mitigate the effects of climate change but also to preserve their ecosystem services as long‐term sink for microplastic.