bluuebunny/crossref_metadata_2025 huggingface dataset:
Hypoxia-inducible factor 1 (HIF-1) as a biomarker of acute kidney injury in patients with acute decompensation of chronic heart failure
Authors: Efremova E. V. , Shutov A. M. , Makeeva E. R. , Menzorov M. V. , Sakaeva E. R. , Strakhov A. A.
Published: March 2019

Actuality.Impaired kidney function adversely influences both immediate and remote prognosis for patients with chronic heart failure (CHF). However, early detection and prediction of acute kidney injury (AKI) are understudied.

The aimof study was to investigate hypoxia-inducible factor 1 (HIF-1) as a biomarker for early diagnosis of AKI and determining prognosis in patients with acute decompensated CHF (ADCHF).

Materials and methods:84 patients admitted for ADCHF (18 women; mean age, 61.4±7.1) were evaluated. ADCHF was diagnosed in accordance with SEHF guidelines for diagnosis and treatment of chronic heart failure (RCS, 2016). AKI was diagnosed according to KDIGO criteria (2012). HIF-1, N-terminal pro B-type natriuretic peptide (NТ-proBNP), and erythropoietin were measured in blood serum. The follow-up period lasted for 12 months.

Results:AKI was diagnosed in 27 (32.1 %) patients. Level of HIF-1 was 1.27±0.63 ng / ml; NТ-proBNP – 2469.6 (interquartile range (IQR), 1312.2; 3300.0) pg / ml; eryhthropoietin – 56.0 mIU / ml (IQR, 13.2; 68.1). No correlation was found between HIF-1 and glomerular filtration rate, NТ-proBNP, or erythropoietin. Differences in biomarker levels were not observed between patients with and without AKI; however, HIF-1 was higher in the group of deceased patients than in the group of survived patients (1.64±0.9 vs. 1.17±0.44 ng / ml, р=0.004), which was not observed for NТ-proBNP and erythropoietin.

Conclusion.AKI was observed in every third patient with ADCHF. In ADCHF, HIF-1 was not correlated with the kidney function; however, a relationship was found between the HIF-1 level and prediction for patients with CHF.
Evaluation of central neuropathy in type 2 diabetes mellitus: a case control study
Authors: Balakrishnan R. , Ramadoss K. , Prasanna Venkatesan E.
Published: March 2019

Background: Diabetes mellitus (DM) is a global pandemic affecting almost every organ in the body. Peripheral nervous system involvement in diabetes is well known but there are not many studies on central nervous system involvement. Visual evoked potential (VEP) is a sensitive, non-invasive test to detect central demyelination of optic nerve. The objective was to compare the visual evoked potentials in type-2 DM patients with that of healthy controls and to find out if any correlation is there with the duration and glycaemic control of the disease and to compare incidence of peripheral and central neuropathy in DM patients.Methods: Author included 50 DM patients and 50 age and sex matched controls. Patients with previous stroke, demyelination, diabetic retinopathy and other ophthalmological disorders were excluded. VEP was recorded using pattern reversal stimulation with EMG RMS MARK II machine and p100 latency was measured.Results: P100 latencies (ms) was significantly prolonged in diabetics with mean±SD of (111.24±5.28 ms) as compared to controls (101.30±1.66 ms) with p value <0.003. Also, there was significant correlation between duration of DM and P100 latency prolongation, but no significant correlation was present when compared with glycaemic control.Conclusions: Central neuropathy is very common in DM. It is related to duration of DM and not HbA1c unlike PNP which is related to both. Central neuropathy occurs even prior to development of retinopathy or PNP. Hence, VEP is a non-invasive and sensitive screening tool for early neurological involvement in DM.
Pharmacovigilance of corticosteroids in dermatological diseases
Authors: Reddy Narotham , Parveen S. , Syed Allahuddin
Published: March 2019

Background: The aim of the study was to conduct the monitoring, detection, assessment and prevention of corticosteroid induced adverse drug reactions in dermatological diseases.Methods: Patient demographic details, past medical, medication history, lab investigations, allergic history were collected patient were followed and data collected every 1 month from the day of patient recruitment. The 1st, 2nd and 3rd follow ups were done, analysis of ADRs was done by using scales at each follow-up. In statistical analysis, data was articulated in percentage. A prospective, interventional study were designed.Results: In present study, author have recruited 40 subjects of which authors categorized ADRs based on different systems. In that 14 (56%) ADRs were identified in cardiovascular system and it was the majorly affected organ system followed by endocrine system 4 (16%). In 40 patients, 25 patients developed ADRs. In these male patients was 14 (56%) and female patients was 11 (44%). In 25, the majorly developed ADR was hypertension 13 (52%) followed by DM 4 (16%). In all ADRs majorly developed due to use of Prednisolone 17 (42%). The developed ADRs majorly in the age group of 41-50 (48%) years followed by 31-40 (16%) and 51-60 (16%).Conclusions: The study found that incidence of ADRs in males was higher than that of the females. Prednisolone was the most common drug associated with the ADRs. Majority of reported ADRs were managed by giving suitable interventions and most of the patients recovered after management.
Craniofacial dermoid cyst: a case report
Authors: Faoury Morad , Mitrasinovic Stefan , Hellier William , Mathad Nijaguna , Ethunandan Madanagopalan
Published: March 2019

We describe a case of a craniofacial dermoid cyst in a 16-month boy treated at our tertiary referral centre. The patient presented with a soft tissue swelling in the mid forehead extending down to the glabella. Computed tomography and magnetic resonance imaging scans demonstrated a peripherally enhancing cystic lesion with a defect in the underlying frontal bone. The clinical and imaging features were suggestive of a dermoid cyst with intracranial extension. The cyst became infected pre-operatively and this episode was managed by aspiration and antibiotics. Definitive management was by excision of the extra and intra-cranial components of the lesion via a bifrontal craniotomy. The presentation, investigations and management of this lesion is discussed.
Bilateral Essure Perforation into the Abdominal Cavity
Authors: Adedayo Pelumi , Scheiber Michael
Published: March 2019

The Essure implant is a Food and Drug Administration (FDA) - approved form of hysteroscopic sterilization. The  device has been available since 2002 with over half a million placed in the United States. The safety and efficacy profile has been demonstrated in the literature and supported by the FDA. Here, we present a rare case of bilateral perforation into the abdominal cavity with one device ultimately let in-situ. Although Bayer, the manufacturer of Essure, plans to stop sale of the product by December 31, 2018 for financial reasons, providers may continue to have questions and concerns from implants placed previously.
Magnetization Transfer MRI of Breast Cancer in the Community Setting: Reproducibility and Preliminary Results in Neoadjuvant Therapy
Authors: Virostko John , Sorace Anna G. , Wu Chengyue , Ekrut David , Jarrett Angela M. , Upadhyaya Raghave M. , Avery Sarah , Patt Debra , Goodgame Boone , Yankeelov Thomas E.
Published: March 2019

Repeatability and reproducibility of magnetization transfer magnetic resonance imaging of the breast, and the ability of this technique to assess the response of locally advanced breast cancer to neoadjuvant therapy (NAT), are determined. Reproducibility scans at 3 different 3 T scanners, including 2 scanners in community imaging centers, found a 16.3% difference (n = 3) in magnetization transfer ratio (MTR) in healthy breast fibroglandular tissue. Repeatability scans (n = 10) found a difference of ∼8.1% in the MTR measurement of fibroglandular tissue between the 2 measurements. Thus, MTR is repeatable and reproducible in the breast and can be integrated into community imaging clinics. Serial magnetization transfer magnetic resonance imaging performed at longitudinal time points during NAT indicated no significant change in average tumoral MTR during treatment. However, histogram analysis indicated an increase in the dispersion of MTR values of the tumor during NAT, as quantified by higher standard deviation (P = .005), higher full width at half maximum (P = .02), and lower kurtosis (P = .02). Patients' stratification into those with pathological complete response (pCR; n = 6) at the conclusion of NAT and those with residual disease (n = 9) showed wider distribution of tumor MTR values in patients who achieved pCR after 2–4 cycles of NAT, as quantified by higher standard deviation (P = .02), higher full width at half maximum (P = .03), and lower kurtosis (P = .03). Thus, MTR can be used as an imaging metric to assess response to breast NAT.
Assessing Treatment Response of Glioblastoma to an HDAC Inhibitor Using Whole-Brain Spectroscopic MRI
Authors: Gurbani Saumya S. , Yoon Younghyoun , Weinberg Brent D. , Salgado Eric , Press Robert H. , Cordova J. Scott , Ramesh Karthik K. , Liang Zhongxing , Vega Jose Velazquez , Voloschin Alfredo , Olson Jeffrey J. , Schreibmann Eduard , Shim Hyunsuk , Shu Hui-Kuo G.
Published: March 2019

Histone deacetylases regulate a wide variety of cellular functions and have been implicated in redifferentiation of various tumors. Histone deacetylase inhibitors (HDACi) are potential pharmacologic agents to improve outcomes for patients with gliomas. We assessed the therapeutic efficacy of belinostat (PXD-101), an HDACi with blood–brain barrier permeability. Belinostat was first tested in an orthotopic rat glioma model to assess in vivo tumoricidal effect. Our results showed that belinostat was effective in reducing tumor volume in the orthotopic rat glioma model in a dose-dependent manner. We also tested the antidepression activity of belinostat in 2 animal models of depression and found it to be effective. Furthermore, we confirmed that myo-inositol levels improved by belinostat treatment in vitro. In a human pilot study, it was observed that belinostat in combination with chemoradiation may delay initial recurrence of disease. Excitingly, belinostat significantly improved depressive symptoms in patients with glioblastoma compared with control subjects. Finally, spectroscopic magnetic resonance imaging of 2 patient cases from this pilot study are presented to indicate how spectroscopic magnetic resonance imaging can be used to monitor metabolite response and assess treatment effect on whole brain. This study highlights the potential of belinostat to be a synergistic therapeutic agent in the treatment of gliomas.
Gleason Probability Maps: A Radiomics Tool for Mapping Prostate Cancer Likelihood in MRI Space
Authors: McGarry Sean D. , Bukowy John D. , Iczkowski Kenneth A. , Unteriner Jackson G. , Duvnjak Petar , Lowman Allison K. , Jacobsohn Kenneth , Hohenwalter Mark , Griffin Michael O. , Barrington Alex W. , Foss Halle E. , Keuter Tucker , Hurrell Sarah L. , See William A. , Nevalainen Marja T. , Banerjee Anjishnu , LaViolette Peter S.
Published: March 2019

Prostate cancer is the most common noncutaneous cancer in men in the United States. The current paradigm for screening and diagnosis is imperfect, with relatively low specificity, high cost, and high morbidity. This study aims to generate new image contrasts by learning a distribution of unique image signatures associated with prostate cancer. In total, 48 patients were prospectively recruited for this institutional review board–approved study. Patients underwent multiparametric magnetic resonance imaging 2 weeks before surgery. Postsurgical tissues were annotated by a pathologist and aligned to the in vivo imaging. Radiomic profiles were generated by linearly combining 4 image contrasts (T2, apparent diffusion coefficient [ADC] 0-1000, ADC 50-2000, and dynamic contrast-enhanced) segmented using global thresholds. The distribution of radiomic profiles in high-grade cancer, low-grade cancer, and normal tissues was recorded, and the generated probability values were applied to a naive test set. The resulting Gleason probability maps were stable regardless of training cohort, functioned independent of prostate zone, and outperformed conventional clinical imaging (area under the curve [AUC] = 0.79). Extensive overlap was seen in the most common image signatures associated with high- and low-grade cancer, indicating that low- and high-grade tumors present similarly on conventional imaging.
Developing a Pipeline for Multiparametric MRI-Guided Radiation Therapy: Initial Results from a Phase II Clinical Trial in Newly Diagnosed Glioblastoma
Authors: Kim Michelle M. , Parmar Hemant A. , Aryal Madhava P. , Mayo Charles S. , Balter James M. , Lawrence Theodore S. , Cao Yue
Published: March 2019

Quantitative mapping of hyperperfused and hypercellular regions of glioblastoma has been proposed to improve definition of tumor regions at risk for local recurrence following conventional radiation therapy. As the processing of the multiparametric dynamic contrast-enhanced (DCE-) and diffusion-weighted (DW-) magnetic resonance imaging (MRI) data for delineation of these subvolumes requires additional steps that go beyond the standard practices of target definition, we sought to devise a workflow to support the timely planning and treatment of patients. A phase II study implementing a multiparametric imaging biomarker for tumor hyperperfusion and hypercellularity consisting of DCE-MRI and high b-value DW-MRI to guide intensified (75 Gy/30 fractions) radiation therapy (RT) in patients with newly diagnosed glioblastoma was launched. In this report, the workflow and the initial imaging outcomes of the first 12 patients are described. Among all the first 12 patients, treatment was initiated within 6 weeks of surgery and within 2 weeks of simulation. On average, the combined hypercellular volume and high cerebral blood volume/tumor perfusion volume were 1.8 times smaller than the T1 gadolinium abnormality and 10 times smaller than the FLAIR abnormality. Hypercellular volume and high cerebral blood volume/tumor perfusion volume each identified largely distinct regions and showed 57% overlap with the enhancing abnormality, and minimal-to-no extension outside of the FLAIR. These results show the feasibility of implementing a workflow for multiparametric magnetic resonance-guided radiation therapy into clinical trials with a coordinated multidisciplinary team, and the unique and complementary tumor subregions identified by the combination of high b-value DW-MRI and DCE-MRI.
Comparison of Voxel-Wise and Histogram Analyses of Glioma ADC Maps for Prediction of Early Therapeutic Change
Authors: Chenevert Thomas , Malyarenko Dariya , Galbán Craig , Gomez-Hassan Diana , Sundgren Pia , Tsien Christina , Ross Brian
Published: March 2019

Noninvasive imaging methods are sought to objectively predict early response to therapy for high-grade glioma tumors. Quantitative metrics derived from diffusion-weighted imaging, such as apparent diffusion coefficient (ADC), have previously shown promise when used in combination with voxel-based analysis reflecting regional changes. The functional diffusion mapping (fDM) metric is hypothesized to be associated with volume of tumor exhibiting an increasing ADC owing to effective therapeutic action. In this work, the reference fDM-predicted survival (from previous study) for 3 weeks from treatment initiation (midtreatment) is compared to multiple histogram-based metrics using Kaplan–Meier estimator for 80 glioma patients stratified to responders and nonresponders based on the population median value for the given metric. The ADC histogram metric reflecting reduction in midtreatment volume of solid tumor (ADC < 1.25 × 10−3 mm2/s) by >8% population-median with respect to pretreatment is found to have the same predictive power as the reference fDM of increasing midtreatment ADC volume above 4%. This study establishes the level of correlation between fDM increase and low-ADC tumor volume shrinkage for prediction of early response to radiation therapy in patients with glioma malignancies.
Multiparameter MRI Predictors of Long-Term Survival in Glioblastoma Multiforme
Authors: Stringfield Olya , Arrington John A. , Johnston Sandra K. , Rognin Nicolas G. , Peeri Noah C. , Balagurunathan Yoganand , Jackson Pamela R. , Clark-Swanson Kamala R. , Swanson Kristin R. , Egan Kathleen M. , Gatenby Robert A. , Raghunand Natarajan
Published: March 2019

Standard-of-care multiparameter magnetic resonance imaging (MRI) scans of the brain were used to objectively subdivide glioblastoma multiforme (GBM) tumors into regions that correspond to variations in blood flow, interstitial edema, and cellular density. We hypothesized that the distribution of these distinct tumor ecological “habitats” at the time of presentation will impact the course of the disease. We retrospectively analyzed initial MRI scans in 2 groups of patients diagnosed with GBM, a long-term survival group comprising subjects who survived >36 month postdiagnosis, and a short-term survival group comprising subjects who survived ≤19 month postdiagnosis. The single-institution discovery cohort contained 22 subjects in each group, while the multi-institution validation cohort contained 15 subjects per group. MRI voxel intensities were calibrated, and tumor voxels clustered on contrast-enhanced T1-weighted and fluid-attenuated inversion-recovery (FLAIR) images into 6 distinct “habitats” based on low- to medium- to high-contrast enhancement and low–high signal on FLAIR scans. Habitat 6 (high signal on calibrated contrast-enhanced T1-weighted and FLAIR sequences) comprised a significantly higher volume fraction of tumors in the long-term survival group (discovery cohort, 35% ± 6.5%; validation cohort, 34% ± 4.8%) compared with tumors in the short-term survival group (discovery cohort, 17% ± 4.5%, p < 0.03; validation cohort, 16 ± 4.0%, p < 0.007). Of the 6 distinct MRI-defined habitats, the fractional tumor volume of habitat 6 at diagnosis was significantly predictive of long- or short-term survival. We discuss a possible mechanistic basis for this association and implications for habitat-driven adaptive therapy of GBM.
The Assessment of fracture healing properties of lovastatin loaded nanoparticles: preclinical study in rat model
Authors: Zhu Peng , Huang Guiyun , Zhang Bing , Zhang Wenzhi , Dang Minyan , Huang Zhang
Published: March 2019

Bone fracture, being mainly caused by mechanical stress, requires special and quick attention for a rapid healing. The study presented here aims at formulating nanoparticulate system to overcome the solubility issues of lovastatin. The lovastatin nanoparticles were successfully prepared by ionotropic gelation method using chitosan and tri-polyphosphate as polymers. Thus prepared nanoparticles were found to be smooth and spherical with average particle size of 87 nm and encapsulation efficiency of 86.5%. The in-vitro drug release was found to be almost 89.6% in the first 360 minutes. Artificial fracture was produced in female Wistar rats at right leg using fracture apparatus. After administration of lovastatin nanoparticles or saline solution, the respective groups were observed for various parameters. The X-ray imaging showed that lovastatin accelerated bone healing, compared to control. The growth of animals was not hampered by lovastatin by any means. The radiographic examination confirmed a role of lovastatin in increasing bone density. The histological study showed the broken, proliferated and discontinued trabecullae in the control, while at the same time point, the normal, thick, continuous and connected trabecullae were observed in animals administered with lovastatin nanoparticles. The biomechanical studies showed high breaking resilience and minimum bone brittleness in animals injected with lovastatin nanoparticles. Considering these observations we state that lovastatin helps in rapid bone healing after fracture via increasing the bone density.
Evaluation of Relationship Between Single-Nucleotide Polymorphism in TNF-Gene Promoter and Susceptibility to Atherosclerosis in Fatemeh Zahra Hospital
Authors: Nouri Somayyeh , Mousavi Zahra , Azizi Soheil , Bagheri Babak , Ataee Ramin
Published: March 2019

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Different Features of Escherichia coli and Klebsiella pneumoniae in Children and Adults
Authors: Sheikhalizadeh Vajihe , Rezaee Mohammad Ahangarzadeh , Langarizadeh Nastaran , Goli Hamid Reza
Published: March 2019

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STUDY OF THE MINERALIZATION OF THE WASTE FROM ANATOMY LABORATORIES OF THE UNDERGRADUATION COURSES OF THE FEDERAL UNIVERSITY OF JEQUITINHONHA AND MUCURI VALLEYS
Authors: De Sousa José Alberto , Corrêa de Souza Marina
Published: March 2019

In spite of it is a dangerous substance already defined as carcinogenic, formaldehyde even widely used in industry and in the academic environment, in Brazil, it still does not present a regulation that delimits what can be considered a safe disposal. Based on the literature, it was defined that 1.61 mg L-1 of formaldehyde represents a safe concentration to be lead to sewage. The proposal of this study is to establish a complete oxidation model of this residue, followed by its simulation using different types of reactor models. The entire process was structured to satisfy the demands from the human and animal anatomy laboratories, both present at Federal University of Jequitinhonha and Mucuri Valleys, in the city of Diamantina, MG. The corpses and carcass washing process implanted provides the effluent which will be treated. The reaction model has three stages, the first follows zero-order kinetics and the other two follow a pseudo-first order kinetic, their specific reaction rates were 0.0457 mol L-1 min-1, 0.0702 min-1 and 0.0144 min-1, respectively. A 150 L BSTR presented satisfactory operation, with a batch time of 7 minutes to achieve a safe disposal. Further tests with the real effluent ought to be implemented in order to compare with the results from the synthetic effluent.
PROCESSO DE MOAGEM DE GARRAFAS PET PÓS-CONSUMO
Authors: Silva Elisângela Aparecida da , Cunha Lins Vanessa de Freitas , Cotting Fernando
Published: March 2019

Atualmente, grandes volumes de lixo são descartados, com isso o meio ambiente é cada vez mais contaminado e degradado. Uma forma de remediação bastante difundida são as implementações de associações que incentivem a coleta seletiva de resíduos. A Associação Brasileira da Industria de PET (ABIPET) acompanha a reciclagem e a reutilização de embalagens de PET no Brasil, segundo estudos realizados o volume de descarte incorretamente ainda é superior quando comparado ao volume produzido. O PET é um polímero de engenharia com excelentes propriedades e com vasta aplicação. Após o processamento grande parte das propriedades são mantidas, neste sentido, a reutilização desse polímero com matéria prima é favorável. Porém, o PET reciclado é fornecido em forma de flakes o que limita a sua aplicação. A proposta desse trabalho é fornecer uma metodologia para moagem das garrafas PET pós-consumo com granulometria abaixo de 0,3 mm para ampliar aplicabilidade. O material produzido foi caracterizado pelas técnicas de FTIR, DSC, TG e distribuição granulométrica.
MISTURAS ELASTOMÉRICAS DE SBR/BORRACHA NITRÍLICA CARBOXILADA COMPATIBILIZADAS COM POLIACROLEÍNA
Authors: Pinto Patricia Re , Nascimento Ziceli Cardozo , Sirqueira Alex da Silva
Published: March 2019

Misturas elastoméricas são extensivamente estudadas com intuito de melhorar as propriedades finais dos materiais vulcanizados. Neste trabalho foi avaliada a mistura do elastômero sbr com a borracha nitrílica carboxilada na proporção de 50:50 %. Entretanto, devido às diferenças de polaridade entre os dois elastômeros a mistura apresenta imiscibilidade e incompatíbilidade, sendo necessária a utilização de agentes compatibilizantes. As misturas foram compatibilizadas com o oligômero de acroleína em diferentes proporções (1,5; 2,5 e 5,0). Na síntese do oligômero utilizou-se a razão de monômero/iniciador de 8. Os resultados de ftir confirmaram a conversão no oligômero e, através de gpc, determinou-se a massa molecular ponderal média de 582 g/mol. As misturas elastoméricas de sbr/xnbr foram processadas em misturador aberto de rolos, em seguida foram avaliadas as propriedades de vulcanização em reometro de disco oscilatório (rdo), a resistência à tração do material vulcanizado e o grau de inchamento em diferentes solventes orgânicos. O oligômero de acroleína atuou aumentando a densidade de ligações cruzadas da mistura sbr/xnbr, confirmado pelo aumento no valor de torque máximo no rdo. A cinética de vulcanização também foi catalisada pela presença dos oligômeros, observado pelo aumento de aproximadamente 86 % na taxa de vulcanização em relação a mistura não compatibilizada. Os resultados de resistência à tração foram superiores para as misturas compatibilizadas. A presença do oligômero também reduziu o grau de inchamento em hexano, o que corrobora com os dados de reometria e resistência à tração. O teor de acroleína que apresentou o melhor desempenho foi de 2,5%.
IN-SILICO STUDY FOR PREDICTING THE INHIBITION CONCENTRATION OF SOME HETEROCYCLIC AND PHENYLIC COMPOUNDS AS POTENT HERBICIDES USING THE MLR - GFA APPROACH
Authors: TUKUR SAIDU , SHALLANGWA GIDEON ADAMU , UZAIRU ADAMU , IBRAHIM ABDULKADIR
Published: March 2019

The study of the quantitative structure-activity relationship (QSAR) was used in a set of data from 43 heterocyclic and phenylic inhibitor compounds in order to establish a correlation between the inhibitory concentrations of the compounds in question and their structures. The optimization method of the density  functional theory (DFT) was used to minimize the energy of the 3D structures using the Becke functional  hybrid Exchange (B3)  parameter with the Lee, Yang, and Parr Functional Correlation (LYP), commonly called the B3LYP functional Hybrid and 6-31G* Basis Set (B3LYP/6-31G*) method, to discover their molecular Quantum descriptors. Five models of QSAR were generated with the technique of genetic function algorithm (GFA). Among the five models generated, model 1 was selected as the best model because of its statistical significance (Friedman's LOF = 0.3008, R2 = 0.9784, R2adj = 0.9739, Qcv2 = 0.9675 and R2pred = 0.7348). The meticulous model was evaluated by means of the Leave One out cross-validation (LOO-CV) approach, external validation of the compounds of the test set, Y -randomization test and applicability domain (Williams Plot). The proposed QSAR model was highly predictive and vigorous with good validation parameters. The molecular descriptors used in the model should be considered of great importance in improving the inhibitory concentrations of the herbicides and also in the conception of new herbicides with a higher concentration of inhibitor.
INSILICO MODELLING ON SOME C14-UREA TETRANDRINE COMPOUNDS AS POTENT ANTI-CANCER AGAINST HUMAN ERYTHROLEUKEMIA (HEL) CELL LINE
Authors: Abdullahi Mustapha , Shallangwa Gideon A. , Ali Tijjani , Uzairu Adamu
Published: March 2019

Insulin modeling was performed on 28 C14-urea tetrandrine compounds as inhibitors of leukemic (HEL) cell lines using Quantitative Structure-Activity Relationship (QSAR) method. The structure of the inhibitors was correctly drawn, then geometrically optimized at Density Functional Theory (DFT) level (DFT / B3LYP / 6-31G *) with Spartan 14 V1.1.4. Also, molecular descriptors of the inhibitors were calculated with PaDEL calculator, and the results were partitioned into training and test set after data pretreatment. The training set was used to generate a model by employing genetic function approximation in choosing best descriptors to form the model. The validation parameters of the model include; R ^ 2 (train) at 0.8067, LOF 0.037 r ^ 2 (QCV) to 0.6378 R ^ 2 (test) 0.7629 of the CRP ^ 2 and  the  0. 6990 Which have passed the acceptance criteria for a QSAR model worldwide. In addition, the model depicted four (4) descriptors, AATS4v, AATS5i, AATSC5i, and GATS5m with positive meanings signifying that increase in these descriptors will positively influence and increase the activity of the inhibitors. This study depicts a route in designing and synthesizing new C14-urea tetrandrine compounds with better inhibitory potentials.
INSILICO STUDIES OF SULFUR-CONTAINING SHIKONIN OXIME DERIVATIVES AS INHIBITORS OF MGC 803 GASTRIC CANCER CELL LINE
Authors: Ismail Sagir Yusuf , UZAIR A. , SAGAGI B.
Published: March 2019

Quantitative structural activity relationship and molecular docking studies were performed to predict the anticancer activity of 41 sulfur-containing shikonin oxime derivatives. Quantum chemical calculations method (Density Functional Theory with B3LYP/6-31G* basis set) were used in optimising the studied molecules to find the lowest geometry. Genetic function algorithm was employed in selecting five relevent molecular descriptors that derived a quantitative relationship between the anticancer activity and the structural properties of the studied compounds. Based on the value of coefficient of correlation R2 0.833, R2ext value of 0.64 R2adj value of 0.799 and Q2 value of 0.737, the model was found to be robust, highly satisfactory and predictive. Docking study between the derivatives of sulfur- containing shikonin oxime and fibroblast growth factor receptor (5A46) revealed that compound number 24 has the highest binding energy of -9.3 kcal/mol and all the other compounds has favourable binding affinity toward the target receptor.
QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP STUDY ON THE INHIBITORY ACTIVITY OF COPPER SCHIFF BASE COMPLEXES AGAINST CANDIDA ALBICAN
Authors: Muhammad Umma , Uzairu Adamu , Idris Sulaiman Ola
Published: March 2019

Quantitative Structure Activity Relationship (QSAR) study was performed on Copper Schiff base complexes. Multiple Linear Regression analysis and genetic function algorithms was employed to derive QSAR model for better activity. The derived QSAR model having Squared Correlation Coefficient R2 = 0.8345, Cross Validation Squared Correlation Coefficient Q2 = 0.6681 and predicted R squared (R2pred ) = 0.5980. The predictive ability of the derived model was also confirmed by internal and external cross validation techniques. The QSAR model indicate that the descriptors (MATS4p) Moron autocorrelation of lag 4 weighed by polarizability,(RCI) Ring Complexity index, (G2m) 2nd component symmetry directional WHIM index/weighted by mass, BI0 [N-O] Presence/absence of N-O at topological distance 10 and (nF) Number of Fluorine atoms plays an important role in predicting the activities against anti-candida albican. The result obtained in this study was used in designing more potent Copper Complexes as anti-candida albican agents.
THEORETICAL MODELLING FOR INVESTIGATING SOME ACTIVE COMPOUNDS AS POTENT INHIBITORS AGAINST LUNG CANCER: A MULTI-LINEAR REGRESSION APPROACH
Authors: Adeniji Shola Elijah , Ovaku Momohjimoh Idris , Saidu Tukur , Ugochukwu Ahanonu Saviour , Shallangwa Gideon , Uzairu Adamu
Published: March 2019

A Quantitative Structure Activity Relationship (QSAR) study has been attempted on ciprofloxacin derivatives as potent anti-lung cancer. QSAR models were derived with the aid of multi-linear regression (MLR) approach using topological, molecular shape, electronic and structural descriptors. The predictive ability of the QSAR models generated  were validated and the best model selected has squared correlation coefficient (R2) of 0.954801, adjusted squared correlation coefficient (Radj) of 0.939265, Leave one out (LOO) cross validation coefficient () value of 0.907523. The external validation set used for confirming the predictive power of the model has its R2pred of 0.8387. The QSAR models point out that AATSC2m, VR3_Dzp and BIC2 are the important descriptors effectively describing the bioactivity of these compounds.
STUDY OF BIODIESEL PRODUCTION BY HETEROGENEOUS CATALYSIS USING MAGNETIC NANOPARTICLES SUPPORTED IN SILICA IN A PACKED BED REACTOR
Authors: Boury Allan , Zussa Andeson , Campos Christian , Felix Marta , Felix Mariana , Marin Maristhela , Ferreira Luis , Ferreira Newton , Toma Sergio , Toyama Marcos
Published: March 2019

In this work the biodiesel production was studied through heterogeneous catalysis using SPIONs in silica. The reaction was conducted in a fixed bed reactor immersed in thermostated bath to maintain the temperature at 60 °C using 1:6:5 (soybean/methanol/tert-butanol) molar ratios between reagents and reaction times of 6,8 and 10 hours. The reactions were also conducted in Erlenmeyer incubators at Shaker under the same conditions of molar ratios and temperature, with agitation of 300 rpm, samples being withdrawn from time to time ranging from 0.25 to 8 hours. The results showed that when the reaction was conducted in a fixed bed reactor the best conversion was achieved in batch of 10 hours being equal to 3.18% and that when incubated in Shaker a conversion of 36.04% in 8 hours. In this study the kinetic constant was also determined from the experiments incubated at Shaker and proposed a transesterification process model using the ASPEN PLUS (R) process simulator.
CONFECÇÃO DE MATERIAL DIDÁTICO PELOS MONITORES DA DISCIPLINA DE ENFERMAGEM EM GINECOLOGIA E OBSTETRÍCIA
Authors: Paulo Brena Elisa de , Condeles Paulo César , Ruiz Mariana Torreglosa
Published: March 2019

Objetivo: relatar a experiência da confecção de um manual sobre os cuidados de enfermagem com medicamentos mais utilizados em Ginecologia e Obstetrícia. Método: estudo descritivo do tipo relato de experiência, proporcionado a partir da vivência dos acadêmicos junto ao programa de monitoria da Universidade Federal do Triângulo Mineiro (UFTM) na disciplina de Enfermagem em Ginecologia e Obstetrícia, cujas atividades ocorreram no período de abril a julho de 2017. Resultados: Os acadêmicos que estavam cursando a disciplina se mostraram extremamente satisfeitos com o manual, destacando como sendo a melhor atividade realizada pelos monitores. Foi relatado que com este material eles se sentiram mais seguros e preparados perante o conhecimento exigido para realizarem o ensino clínico. Conclusões: A monitoria trouxe benefícios no processo de ensino-aprendizagem para todos os envolvidos, além disso, o material didático foi extremamente importante para aprimoramento e fixação do conteúdo tratado.
ANÁLISE ESPACIAL DA VIOLÊNCIA AUTOPROVOCADA EM ADOLESCENTES: SUBSÍDIO PARA ENFRENTAMENTO
Authors: De Abreu Paula Daniella , Da Silva Lúcio Firley Poliana , De Araújo Ednaldo Cavalcante , Ribeiro de Vasconcelos Eliane Maria , Da Cunha Tarcisio Neves , Dos Santos Claudia Benedita
Published: March 2019

RESUMOObjetivo: analisar a correlação entre as taxas brutas de violência autoprovocada em adolescentes e ano de ocorrência e o padrão espacial da ocorrência dos casos notificados de violência autoprovocada em adolescentes. Método: estudo ecológico com tendência temporal, desenvolvido a partir de dados notificados no período de 2009 a 2014 referentes aos casos de violência autoprovocada em adolescentes residentes no Estado de Pernambuco, coletados por município pelo Sistema de Informação de Agravos de Notificação. Os dados foram analisados com o auxílio do programa TerraView, versão 4.2.2, a partir das bases cartográficas municipais de Pernambuco e quantitativo populacional fornecidos pelo Instituto Brasileiro de Geografia e Estatística. Resultados: obteve-se correlação linear estatística positiva entre as variáveis representadas pelas taxas brutas e ano de ocorrência, além da inexistência de associação espacial significante. Conclusões: a aplicação de abordagens integradas que considerem a situação do entorno, configura-se em importante estratégia para construção de ações em saúde.  Descritores: Análise Espacial; Promoção da Saúde; Violência; Comportamento do Adolescente; Enfrentamento.
TOQUE TERAPÊUTICO COMO ESTRATÉGIA PARA REDUÇÃO DE ESTRESSE EM ESTUDANTES DE ENFERMAGEM
Authors: Fornari Nerizane Cerutti , Piexak Diéssica Roggia , De Oliveira Aline Cristina Calçada , Abreu Daiane Porto Gautério , Barlem Edison Luiz Devos , Medeiros Silvana Possani
Published: March 2019

Objetivo: Analisar o toque terapêutico como estratégia para redução de estresse em estudantes de enfermagem. Métodos: Estudo longitudinal do tipo caso-controle realizado com 20 estudantes de enfermagem. O instrumento de pesquisa foi uma escala de avaliação de estresse antes e após a aplicação de toque terapêutico. Para análise dos dados, utilizaram-se os testes de Wilcoxon e Kruskal-Wallis. Resultados: O toque terapêutico mostrou-se eficaz para redução do estresse nos domínios 1, 3 e 6 da escala, não sofrendo influência de fatores como atividade de lazer, renda, ter ou não filhos, e série atual. Conclusão: O toque terapêutico foi eficiente na redução dos níveis de estresse, auxiliando os estudantes de enfermagem quanto ao enfrentamento do mesmo. Outros estudos são necessários para aprofundar pesquisas na área, que visem propiciar recursos a serem buscados pelos estudantes de enfermagem para minimizar o estresse vivenciado.
FATORES DIFICULTADORES NA REALIZAÇÃO DAS TECNOLOGIAS LEVES NO CUIDADO DO ENFERMEIRO NA ATENÇÃO BÁSICA
Authors: Souza Joyce Wadna Rodrigues de , Silva Fabrícia Cristina Vidal , Brito Paloma Karen Holanda , Silva Rayara Cibelle Ribeiro da , Alves Bruna , Fernandes Marcelo Costa
Published: March 2019

Objetivo: identificar os obstáculos encontrados na execução de atividades relacionadas às tecnologias leves voltadas ao cuidado do enfermeiro na Atenção Básica. Método: Trata-se de um estudo descritivo com abordagem qualitativa realizado com 15 Enfermeiros das Estratégias de Saúde da Família do município de Cajazeiras, Paraíba. Foi utilizado para coleta de dados uma entrevista semiestruturada, que aconteceu entre os meses de janeiro e fevereiro de 2016, após a aprovação do Comitê de Ética e Pesquisa. Resultados: Percebeu-se a existência de alguns fatores que prejudicam a utilização das tecnologias leves do cuidado, dentre eles, o tempo reduzido para realizar o atendimento à população, estrutura física inadequada, imediatismo do atendimento, a pressão da demanda para o trabalho. Conclusão: É imprescindível que exista o apoio da gestão oferecendo ações de educação permanente para com os profissionais da saúde sobre a importância da utilização das tecnologias interacionistas em seus cotidianos de práticas.
EDITORIAL - PESQUISA EM SAÚDE E RESPONSABILIDADE SOCIAL
Authors: Soares Sônia Maria
Published: March 2019

Em tempos de incerteza, chegamos ao final de 2018 celebrando conquistas e realizações, mas com muitas inquietações e dúvidas frente às reformas sociais e econômicas, que podem surgir a partir do atual cenário político brasileiro. Portanto, colocar à disposição dos leitores da REAS mais um número da revista, é acima de tudo, uma conquista e a garantia do cumprimento da sua missão de difundir a ciência da enfermagem e áreas afins. Ao mesmo tempo, cabe aplaudir a aprovação da indexação da REAS na base de dados CINAHL- Cumulative Index to Nursing and Allied Health Literature, o que amplia a divulgação e a exposição do periódico.
Factors Affecting Initiation and Duration of Breastfeeding Among Off-Reserve Indigenous Children in Canada
Authors: Romano Isabella , Cooke Martin , Wilk Piotr
Published: March 2019

Indigenous children in Canada are less likely to be breastfed compared to non-Indigenous children; however, little information about rates and correlates of breastfeeding exist. We used a nationally representative survey to examine breastfeeding initiation (n = 9,330) and duration (n = 6,760) among First Nations, Métis, and Inuit children. In our sample, 72.5% of children had been breastfed, and 57.9% of these individuals were breastfed until six months. Factors associated with increased breastfeeding included mothers’ educational attainment, children’s weight at birth, mothers' residential school attendance, and region of residence. Having Indian Status and lower household income were associated with lower breastfeeding initiation and duration. Our findings suggest that targeted efforts to encourage and support breastfeeding among Indigenous women are needed. Additional research using contemporary data are required in Canada.
Integrated Research of Professional Voice Disorders of Humanitarian Departments’ Teachers
Authors: Peretyaha Liudmyla , Grineva Valentyna , Shulga Iryna , Kuzmichyova Valentina , Shlenova Maryna , Tkachenko Maryna
Published: March 2019

Purpose: To determine the main voice disorders of humanitarian departments’ teachers, their reasons and effective methods to keep the voice in a health condition. Material: In the research participated 142 teachers of H. S. Skovoroda Kharkiv National Pedagogical University and National Aerospace University – "Kharkiv Aviation Institute" (n=106 women, n=36 men). The study involved auditory assessment of teachers' voice and questionnaire in order to determine teachers’ professional voice problems and factors influenced on the status and quality of the voice. Results: It was determine the maximum phonation time for participants of genders, the voice disorders frequency, typical problems with teachers' voice, the positive and negative factors affecting the voice system condition. Also participants answered the questionnaire’s questions about voice using. Conclusions: the study showed that teachers take their voice for granted and do not always care about it; use their voice in an unhealthy condition and they are not always aware of the negative consequences for their health.
Attitude and Self-Efficacy of Students with Motor Impairments Regarding Touch Input Technology
Authors: Schipor Maria-Doina
Published: March 2019

We address in this work the role touch interfaces could play in reducing the inequalities motor disabled students confront with. To this end, we conduct a between subjects experiment, involving students with motor disability and able bodied participants,  investigating both the attitude and the self-efficacy with respect to the utilisation of  touch technology in the everyday life. We rely on the well-established relationship between attitude, self-efficacy, and actual performance in order to explore strategies for increasing the actual performances through psychological means. The statistical analysis indicates significant differences between subjects with motor impairments and able bodied participants in the case of both attitude and self-efficacy. We connect these outcomes with strategies for reducing the inequalities for the students with motor disabilities in the context of educational activities.
Student Perceptions on War Topics and War Anxiety in History Classes
Authors: Tezer Murat , Uzun Gizem Öneri
Published: March 2019

The consequences of wars are not affecting only the humanity that existed in the period of war, but also the generations that lived afterward. These results are passed on to the students through history classes. Determining the change in students’ anxiety levels based on this is the main purpose of the research. The scale developed in the context of this goal is applied to 365 university students. The topics of war and war anxiety in history classes have been evaluated regarding gender, age, origin, the success of history lesson, family members participated in the war, and the idea of "war can come out any time”. While there is a significant difference between variables; gender, the success of history lesson, and the idea of "war can come out anytime," there is no significant difference in variables; age, origin, and having family members participated in the war.
Roles and Responsibilities of Teaching Staff in Promoting Interculturalism
Authors: Enache Roxana Constanţa , Petrescu Ana-Maria Aurelia , Stăiculescu Camelia , Crişan Alina
Published: March 2019

Education can, without a doubt, be a long-term solution to the problems of a multi-ethnic and multicultural society. From a defensive and seclusion closure, schools can become places of openings and communication. From an instrument of assimilation and strengthening of nationalistic characteristics, school can become a tool for the formation of young people, which respecting cultural diversity. With the help of sensitization and training actions, of the representatives of the multiethnic institutions of education, as well as of the local public authorities and the representatives of the civil society, the achievement of these objectives and the prevention of possible tensions will be achieved. These actions can turn school into a true community center and allow them to better respond to specific needs. The intercultural perspective must be at the base of the learning process addressed to all, minorities and majority. The implementation of intercultural education activities, especially in communities with a multicultural character, within the part of the curriculum decided by the school, will contribute to a better knowledge among the different communities, but also to the strengthening of the social cohesion at the local level. Also, intercultural education activities should aim to strengthen the links between school and community - civil society, as well as better communication between school and local authorities.In this paper we want to identify the elements of intercultural education existing in the curriculum of the Romanian education and the way in which interculturality can be promoted as a European competence.Intercultural communication as a trainer’s competence should be considered as a priority both from the point of view of European standards and at national level. Therefore, the professors’ concerns should focus primarily on encouraging behaviors, attitudes and values so as to cause the individual to react desirably to fear, anxiety, curiosity, labeling, ethnocentrism etc.; the development of implicit or explicit hierarchical relations between groups and their impact on communication; on exercising the students’ competences to perceive time and space, the rapport between them, the system of values and beliefs, the way of feeling and thinking, the types of behavior, that is, the entire habitus that each individual accomplishes by socializing in the determined cultural environment ; on the development of identity strategies that participants put into practice to defend themselves against destabilization, to affirm their own identity, to integrate in the group, to make a positive image, to differentiate themselves, to individualize
An Equation for Computing Thermal Capacity of an Electrolyte in a Dissociated Solution
Authors: Akhapkina T.E. , Gurov A.A. , Solovev S.N. , Kozhevnikova S.V.
Published: March 2019

The authors used E.M. Kuznetsova's theory to derive an equation for computing thermal capacity of an electrolyte in a dissociated solution. This equation may also be used to determine such important characteristics as the constant and enthalpy of ion association in electrolyte solutions. This equation is derived from the simplest model, that of ion association, which allows certain solution properties to be adequately described as functions of concentration. The ion association model is based on the equilibrium between ions and ion pairs of the same kind that exists in electrolyte solutions