bluuebunny/crossref_metadata_2025 huggingface dataset:
A first principles insight on structural, electronic, optical and mechanical properties of ZrCl4
Authors: Tse Geoffrey
Published: January 2024

In this paper, using density functional theory (DFT), we present a systematic computational investigation on ZrCl4 in respect of electronic, structural, optical, mechanical properties, which is of great interest in semiconductor physics. Our results show that the metal tetrachloride is a mechanically stable semiconductor with a wide indirect bandgap of [Formula: see text][Formula: see text]eV ([Formula: see text][Formula: see text]eV). ZrCl4 could behave as a brittle material and could be covalent. According to our optical data, a reflectivity of 27.6% could suggest a good material absorption characteristic on the studied material, with a high absorption coefficient of up to [Formula: see text][Formula: see text]cm[Formula: see text]. On the partial density of states plot, the hybridization of electron orbitals between Cl 3p5 states in the valence band and transition Zr 4d2 states in the conduction band is also observed. Our findings advance the fundamental understanding of ZrCl4 material and provide important insights in electronic/optoelectronic applications.
Investigation of structural, electronic, magnetic, and mechanical stability of a non-trivial topology phase in compound full-Heusler alloys TiHfFeX (X=Al, Ga, In)
Authors: Ait Elkoua I. , Masrour R.
Published: January 2024

In this paper, we present studies relating to the structural, electronic, magnetic and mechanical properties of TiHfFeX ([Formula: see text], Ga, In) full Heusler alloys. We will use the GGA-PBE, TB-mBj, GGA-PBEsol, and GGA-WC approximation implemented in the density functional of the theory as integrated into the Wien2k software. However, the full Heusler alloys studied are considered in the ferromagnetic phase for different structural stabilities of the TiHfFeAl, TiHfFeGa and TiHfFeIn phases. types I, II or III, respectively. Calculation of band structures and total electron density of states shows that these alloys can both exhibit topologically non-trivial semi-metallic characteristics with energy bandgaps of 0.010[Formula: see text]eV, 0.014[Formula: see text]eV and 0.018[Formula: see text]eV. The electronic stability of ’such a Heusler structure will have nothing to do with its mechanical stability. Calculations reveal that the systems exhibit semi-metallic ferromagnetism. The elastic constants and the associated elastic moduli confirm its stability given by different elastic constants namely the Cauchy pressure, Poisson’s ratio, the anisotropy factor, Young’s modulus and the shear modulus.
Modelling and analysis of high efficiency silicon solar cell using double layers anti-reflection coatings (ARC)
Authors: Jamaluddin Nur Irdina Iwani Mohd , Yusoff Mohd Zaki Mohd , Malek Mohd Firdaus
Published: January 2024

The modernization that is currently taking over across the world is resulting in numerous advancements in a variety of industries, and the most notable and apparent development is the rising use of solar energy, which has become more prevalent every day. Most companies, residences, schools, and other organizations rely mostly on solar energy as the main source of electricity. It was discovered that anti-reflective coating (ARC) had been applied to solar cells with the goal of increasing power conversion efficiency, decreasing reflection loss, and improving absorption. Although a single layer of ARC is sufficient, applying an additional layer might improve the solar cell application’s effectiveness. Hence, the modeling and analysis of double layers of anti-reflection coating (ARC) with different types of materials have been investigated and evaluated using personal computer one-dimensional (PC1D) simulation software. In this study, the double-layer anti-reflection coating on the solar cell was modeled using PC1D, where this software allowed for one-dimensional simulation of the parameters required for the operation of semiconductor-based solar energy systems. The PC1D simulation reveals that SiO2/TiO2 has the highest efficiency (22.82%) and lowest reflection compared to Si3N4/TiO2 and ZnO/TiO2. Also, SiO2/TiO2 generates the highest external quantum efficiency (EQE) among ARC double layers, making it ideal for silicon solar cell applications in order to boost the solar cell’s efficiency. The results for the effects of current, voltage, reflection, and EQE of the different double layers of ARC have also been studied in this paper.
Linear regression analysis of MHD Maxwell nanofluid flow over a stretched surface of varying thickness with heat flux and chemical reaction
Authors: Ali Aamir , Afzaal Muhammad F. , Sulaiman M. , Hussain S. , Ashraf M.
Published: January 2024

Non-Newtonian materials have been an appealing topic for researchers because of the variety of laboratory and industrial process involving these fluids. There are several kinds of non-Newtonian fluids classified according to their properties. In this study, the Maxwell fluid model is analyzed due to the unique properties and applications of this non-Newtonian material. We have considered the Buongiorno model for nanofluid, which is a two-phase model that accounts for the effects of Brownian motion and thermophoresis on the transport of nanoparticles in a fluid. A stretching surface holding a chemically reactive fluid is assumed. In addition, the study also considers the impacts of heat flux and magnetic fields. The influence of various physical factors on the flow fields is presented and graphically highlighted. Using linear regression and the data point approach, the relationship between the physical parameters, such as rate of heat and mass transfer, at the surface is investigated. The relationship between the various physical parameters was investigated using the t-test approach. The Maxwell fluid parameter influences heat transmission at the surface. As the magnetic field and heat source parameters increases, the rate of heat transfer decreases. Increasing the Deborah number, chemical reaction parameter and magnetic field parameter enhances the mass transfer rate at the surface. The fluid’s velocity decreases with rising magnetic field and Maxwell fluid parameters. The heat source parameter elevates fluid temperature, while inclusion of the chemical reactions parameter reduces nanoparticle concentration.
Optical sensor properties of a novel BODIPY compound for non-enzymatic detection of glucose
Authors: Yıldırım Selma K. , Ömeroğlu İpek , Durmuş Mahmut
Published: January 2024

This work demonstrated the preparation and characterization of a novel 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) derivative containing boronic acid group and investigation of its non-invasive/non-enzymatic fluorescence sensor behavior for determination of glucose. The novel BODIPY derivative bearing boronic acid pinacol ester (BODIPY-1) was synthesized by Sonogashira coupling reaction between Iodo-BODIPY and 4-ethynylphenylboronic acid pinacol ester. The target novel BODIPY-2 compound which was used as a fluorescence probe for the determination of glucose was synthesized from BODIPY-1by changing the pinacol ester group to the boric acid moieties. The fluorescence intensity of the BODIPY-2 fluorophore decreased when it interacted with the glucose. Sensing performance towards to glucose of this probe was evaluated in detail concerning the suitable solvent, linear concentration range, convenient pH, limit of detection (LOD), limit of quantification (LOQ) and selectivity. The LOD value of BODIPY-2 was found 0.19 mM toward glucose. Also, the complex stoichiometry between the BODIPY-2 and glucose molecules was determined by Job’s plot technique.
Counterfactual Explanation for Fairness in Recommendation
Authors: Wang Xiangmeng , Li Qian , Yu Dianer , Li Qing , Xu Guandong
Published: January 2024

Fairness-aware recommendation alleviates discrimination issues to build trustworthy recommendation systems. Explaining the causes of unfair recommendations is critical, as it promotes fairness diagnostics, and thus secures users’ trust in recommendation models. Existing fairness explanation methods suffer high computation burdens due to the large-scale search space and the greedy nature of the explanation search process. Besides, they perform feature-level optimizations with continuous values, which are not applicable to discrete attributes such as gender and age. In this work, we adopt counterfactual explanations from causal inference and propose to generate attribute-level counterfactual explanations, adapting to discrete attributes in recommendation models. We use real-world attributes from Heterogeneous Information Networks (HINs) to empower counterfactual reasoning on discrete attributes. We propose a
Counterfactual Explanation for Fairness (CFairER)
that generates attribute-level counterfactual explanations from HINs for item exposure fairness. Our
CFairER
conducts off-policy reinforcement learning to seek high-quality counterfactual explanations, with attentive action pruning reducing the search space of candidate counterfactuals. The counterfactual explanations help to provide rational and proximate explanations for model fairness, while the attentive action pruning narrows the search space of attributes. Extensive experiments demonstrate our proposed model can generate faithful explanations while maintaining favorable recommendation performance.
HIF-1 contributes to autophagy activation via BNIP3 to facilitate renal fibrosis in hypoxia in vitro and UUO in vivo
Authors: Liu Jing , Livingston Man J. , Dong Guie , Wei Qingqing , Zhang Ming , Mei Shuqin , Zhu Jiefu , Zhang Chun , Dong Zheng
Published: January 2024

Autophagy has been reported to participate in renal fibrosis, but its role and underlying activation mechanism is unclear. In this study, we report the role of HIF-1 in autophagy activation in models of renal fibrosis and further investigate the underlying mechanism.
CFTR expression in human salivary gland acinar cells
Authors: Muñoz Manuel , Acevedo Alejandro , Ovitt Catherine E. , Luitje Martha E. , Maruyama Eri O. , Catalán Marcelo A.
Published: January 2024

This study addresses the uncertainty about the impact of CFTR on human salivary gland function. We found CFTR transcripts in a subset of duct cells known as ionocytes, as well as in acinar cells. Isolated human parotid acinar cells exhibited Cl− conductance consistent with CFTR activity. This marks the first documented evidence of functional CFTR expression in human salivary gland acinar cells.
The TIMP protein family: diverse roles in pathophysiology
Authors: Coates-Park Sasha , Rich Joshua A. , Stetler-Stevenson William G. , Peeney David
Published: January 2024

The tissue inhibitors of matrix metalloproteinases (TIMPs) are a family of four matrisome proteins classically defined by their roles as the primary endogenous inhibitors of metalloproteinases (MPs). Their functions however are not limited to MP inhibition, with each family member harboring numerous MP-independent biological functions that play key roles in processes such as inflammation and apoptosis. Because of these multifaceted functions, TIMPs have been cited in diverse pathophysiological contexts. Herein, we provide a comprehensive overview of the MP-dependent and -independent roles of TIMPs across a range of pathological conditions. The potential therapeutic and biomarker applications of TIMPs in these disease contexts are also considered, highlighting the biomedical promise of this complex and often misunderstood protein family.
Reentry Capsule Reachable Tube Boundary Prediction via Evolutionary Multiobjective Optimization
Authors: Zou Wen , Cui Zhanxin , Li Genghui , Feng Zhiwei , Wang Zhenkun , Gao Qingyu , Zhang Qingbin , Yang Tao
Published: January 2024

In the field of aerospace, solving the boundary problem associated with the parachute-capsule system remains a big challenge. The conventional Monte Carlo method proves inadequate for acquiring comprehensive boundary information. To address this issue, this paper introduces a novel tube prediction scheme by leveraging the natural geometric characteristics of the reachable tube and employing a multiobjective optimization strategy. Initially, a multibody dynamic model with nine degrees of freedom was established and verified by the airdrop test data to ensure the accuracy and reliability of the model. Subsequently, the Sobol sensitivity analysis method was employed to assess uncertain factors that affect the deceleration phase of the reentry capsule. These factors are then utilized to determine the optimization parameters for the multiobjective optimization model. Ultimately, the multiobjective evolutionary algorithm based on decomposition was employed to solve the multiobjective optimization model, and the geometric boundary of the tube corresponds to the Pareto front of the multiobjective optimization. The proposed methodology was validated through a simulation experiment utilizing the Chang’e-5 reentry capsule as an engineering case. The experimental results unequivocally demonstrate the superior accuracy of our approach in predicting the boundary of the reachable tube compared to the Monte Carlo method. This research serves as a valuable reference for calculating reachable tubes in practical engineering scenarios and can be effectively applied to spacecraft search and rescue operations during the reentry phase.
De Novo Onset of Myasthenia Gravis after Kidney Transplantation
Authors: de Souza Aaron , Raj Rajesh
Published: January 2024

Myasthenia gravis occurring de novo after kidney transplantation is a rare course of severe muscle weakness. A 57-year-old female on treatment with peritoneal dialysis following polycystic kidney disease received a renal transplant with standard basiliximab induction. She had no preceding history of neuromuscular problems. Three months after transplant she presented with progressive weakness and fatigability, finally needing a wheelchair to mobilise. Graft function was stable. Examination revealed patchy limb weakness, worsening on repeated exercise. There were no abnormalities in cranial nerves, reflexes, or sensation. Electromyography was normal, but repetitive nerve stimulation studies showed a postsynaptic neuromuscular transmission defect suggestive of myasthenia gravis. Serological testing revealed no putative antibodies. Initial treatment with pyridostigmine was not tolerated. Following an episode of hospitalisation with severe limb weakness, she received intravenous immunoglobulin and showed dramatic improvement, which persisted over the next few weeks. Approximately 6 months later, she had a relapse of her symptoms, which once again responded to intravenous immunoglobulin therapy. De novo myasthenia gravis after transplantation is a rare entity, infrequently reported in the literature. This illness is surprising since immunosuppression after transplant is usually sufficient to prevent immune-mediated disease. This patient had no history of similar illnesses. Delayed physical recovery after major surgery such as renal transplantation is often attributed to other causes such as deconditioning, and patients are often prescribed physiotherapy as a response. In this patient, the profound unexplained weakness that persisted for several weeks after transplant prompted referral to the neurologist, which enabled this rare diagnosis to be made. This story highlights the need to monitor unexpected symptoms closely and to consider a wide differential diagnosis when improvement after transplant is not along usual expected lines. Finally, this case also illustrates the benefits of multidisciplinary involvement in the care of these complex patients.
Design of Novel Poly(Propranolol) Acrylate and Methacrylate Polymers through Radical Polymerization for Antibacterial Activity and Metal Ion Absorption
Authors: Kumar John Santhosh , Kamaraj P. , Vivekanand P. A. , Periyasami Govindasami , Rahaman Mostafizur , Karthikeyan Perumal , Uthappa U. T. , Palaniappan Selvakumar
Published: January 2024

The monomer 1‐(isopropylamino)‐3‐(1‐naphthyloxy)‐2‐propanoacrylate (IANOPA) and monomer 1‐(isopropylamino)‐3‐(1‐naphthyloxy)‐2‐propanomethacrylate (IANOPMA) were synthesized by treating 1‐(isopropylamino)‐3‐(1‐naphthyloxy)‐2‐propanol with acryloylchloride/methacryloyl chloride. The above esterification reactions were carried out in the presence of triethylamine. By employing the free radical polymerization method, the synthesized monomers were converted into polymers by using an initiator 2, 2′‐azobisisobutyronitrile in the presence of nitrogen environment at 70 ± 2°C. The monomers and polymers were characterized by various techniques such as FT‐IR, UV, 1H NMR, and 13C NMR spectroscopic analyses. Further, differential scanning calorimetry (DSC) was used to estimate the glass transition temperature (Tg). Gel permeation chromatography (GPC) was used to estimate the molecular weight of the polymers. In addition, monomer and polymer surfaces’ morphology was analyzed using SEM analysis. As a primary application, the effectiveness of synthesized monomers and polymers was explored as antibacterial agents against gram‐positive bacteria (Staphylococcus aureus) and gram‐negative bacteria (Pseudomonas aeruginosa) which were measured from their inhibitory zone diameters. Further, the synthesized polymers, poly‐IANOPA and poly‐IANOPMA, were utilized for the uptake ability study of heavy metal ions such as Zn2+, Cu2+, Ni2+, and Pb2+ present in water sources by equilibrium method.
Horadam Spinors
Authors: Erişir Tülay
Published: January 2024

Spinors can be expressed as Lie algebra of infinitesimal rotations. Spinors are also defined as elements of a vector space which carries a linear representation of the Clifford algebra typically. The motivation for this study is to define a new and particular sequence. An essential feature of this sequence is that while a generalization is being made, spinors, which have a lot of use in physics, are used. This new sequence defined using spinor representations is called the Horadam spinor sequence; formulas such as the Binet formula, generating function formula, and Cassini formula are given. The Horadam spinors given in this study are a generalization of the spinor representations of Horadam quaternion sequences.
Reliability-Constrained Task Scheduling for DAG Applications in Mobile Edge Computing
Authors: Zhu Liangbin , Shang Ying , Li Jinglei , Jia Yiming , Yang Qinghai
Published: January 2024

The development of the internet of things (IoT) and 6G has given rise to numerous computation-intensive and latency-sensitive applications, which can be represented as directed acyclic graphs (DAGs). However, achieving these applications poses a huge challenge for user equipment (UE) that are constrained in computational power and battery capacity. In this paper, considering different requirements in various task scenarios, we aim to optimize the execution latency and energy consumption of the entire mobile edge computing (MEC) system. The system consists of single UE and multiple heterogeneous MEC servers to improve the execution efficiency of a DAG application. In addition, the execution reliability of a DAG application is viewed as a constraint. Based on the strong search capability and Pareto optimality theory of the cuckoo search (CS) algorithm and our previously proposed improved multiobjective cuckoo search (IMOCS) algorithm, we improve the initialization process and the update strategy of the external archive, and propose a reliability-constrained multiobjective cuckoo search (RCMOCS) algorithm. According to the simulation results, our proposed RCMOCS algorithm is able to obtain better Pareto frontiers and achieve satisfactory performance while ensuring execution reliability.
Mathematical Concepts and Empirical Study of Neighborhood Irregular Topological Indices of Nanostructures TUC4C8p,q and GTUC p,q
Authors: Zaman Shahid , Ullah Asad , Naseer Rabia , Rasool Kavi Bahri
Published: January 2024

A topological index is a structural descriptor of any molecule/nanostructure that characterizes its topology. In the QSAR and QSPR research, topological indices are employed to predict the physical characteristics associated with bioactivities and chemical reactivity within specific networks. 2D nanostructured materials have many exhibit numerous chemical, mechanical, and physical features. These nanomaterials are exceptionally thin, displaying high chemical functionality and anisotropy. For applications necessitating robust surface interactions on a small scale, 2D materials stand out as the optimal choice due to their expansive surface area and status as the thinnest among all discovered materials. This paper characterized the neighborhood irregular topological invariants of nanostructures TUC4C8[p, q] and GTUC[p, q] and derived closed form expressions for them. A comparative analysis is then performed on the basis of these computed indices.
AI-Driven Digital Twin Model for Reliable Lithium-Ion Battery Discharge Capacity Predictions
Authors: Nair Pranav , Vakharia Vinay , Shah Milind , Kumar Yogesh , Woźniak Marcin , Shafi Jana , Fazal Ijaz Muhammad
Published: January 2024

The present study proposes a novel method for predicting the discharge capabilities of lithium-ion (Li-ion) batteries using a digital twin model in practice. By combining cutting-edge machine learning techniques, such as AdaBoost and long short-term memory (LSTM) network, with a semiempirical mathematical structure, the digital twin (DT)—a virtual representation that mimics the behavior of actual batteries in real time is constructed. Various metaheuristic optimization methods, such as antlion, grey wolf optimization (GWO), and improved grey wolf optimization (IGWO), are used to adjust hyperparameters in order to optimize the models. As indicators of performance, mean absolute error (MAE) and root-mean-square error (RMSE) are applied to the models after they have undergone extensive training and ten-fold cross-validation. The models are rigorously trained and cross-validated using the NASA battery aging dataset, a widely accepted benchmark dataset for battery research. The IGWO-AdaBoost digital twin model emerges as the standout performer, achieving exceptional accuracy in predicting the discharge capacity. This model demonstrates the lowest mean absolute error (MAE) of 0.01, showcasing its superior precision in estimating discharge capabilities. Additionally, the root mean square error (RMSE) for the IGWO-AdaBoost DT model is also the lowest at 0.01. The findings of this study offer insightful information about the potential utilization of the digital twin model to accurately predict the discharge capacity of batteries.
Why Millennials Continue to Use WhatsApp? A Focus on Culture and Computer–Human Dialogue
Authors: Allil Kamaal , Faisal Serri , Zia Adil
Published: January 2024

Continuous usage behavior among millennials is crucial, yet factors influencing this behavior are not well understood. This study integrates human-computer interaction and marketing research to investigate the relationship between persuasive dialogue support (PDS), attitudinal loyalty (AL), and continuous-use intention (CI) in the context of WhatsApp. The study also examines the moderating role of four cultural dimensions: uncertainty avoidance (UA), power distance (PD), masculinity (MAS), and individualism (IND) in these relationships. Data was collected from 287 WhatsApp users in four countries, and the proposed theoretical model was tested using structural equation modelling (SEM-PLS). The results indicate that PDS has a direct positive impact on AL, which in turn leads to CI. The study also found that cultural differences can moderate the relationship between PDS and AL and between AL and CI. Therefore, app developers need to consider cultural differences when designing their products and implement persuasive design aspects to boost user loyalty and intention to use. To ensure optimal app performance in diverse cultural settings, developers should strike an appropriate balance between universal design principles and culturally sensitive adaptation. However, the study’s limitations, such as reliance on self-reported data and a relatively small sample size, suggest the need for future research to expand its scope to include participants from a broader range of cultural backgrounds.
Greedy-Mine: A Profitable Mining Attack Strategy in Bitcoin-NG
Authors: Hu Junjie , Jiang Zhe , Xu Chunxiang
Published: January 2024

Bitcoin-NG is an extensible blockchain protocol based on the same trust model as Bitcoin. It divides each epoch into one keyblock and multiple microblocks, effectively improving the transaction processing capacity. Bitcoin-NG adopts a special incentive mechanism (i.e., the transaction fees in each epoch are split to the current and next leader) to maintain its security. However, there are some limitations to the existing incentive analysis of Bitcoin-NG in recent works. First, the incentive division method of Bitcoin-NG only includes some specific mining attack strategies of the adversary, while ignoring more stubborn attack strategies. Second, once adversaries find a whale transaction, they will deviate from the honest mining strategies to obtain an extra reward. In this paper, we are committed to solving these two limitations. First, we propose a novel mining strategy named Greedy-Mine attack. Then, we formulate a Markov reward process (MRP) model to analyze the competition of honest miners and adversaries. Furthermore, we analyze the extra reward of adversaries and summarize the mining power proportion required for malicious adversaries to launch Greedy-Mine to obtain extra returns. Meanwhile, we make a backward-compatibility progressive modification to Bitcoin-NG protocol that would raise the threshold of propagation factor from 0 to 1. Finally, we get the winning condition of adversaries when adopting Greedy-Mine, compared with honest mining. Simulation and experimental results indicate that Bitcoin-NG is not incentive compatible, which is vulnerable to Greedy-Mine attack.
Do Contemporary Cancer Survivors Experience Better Quality of Life? Evaluating a Decade of SEER Medicare Health Outcomes Survey Data
Authors: Allaire Benjamin T. , Horvath Marc L. , Lines Lisa M. , Davidoff Amy J. , Smith Ashley Wilder , Jensen Roxanne E.
Published: January 2024

Background:

A cancer diagnosis may have deleterious effects on health-related quality of life (HRQOL) as adults age. This study examined differences in HRQOL between cancer and matched noncancer Medicare beneficiaries over 65, within and across two time periods.

Methods:

We used novel matching methods on data from the Surveillance, Epidemiology and End Results (SEER)-Medicare Health Outcomes Survey (MHOS) data resource. We matched SEER-MHOS respondents with cancer from a recent period (2015–2019) to respondents with cancer from an earlier period (2008–2012). We then matched these two cohorts, without replacement, to contemporary cohorts without cancer diagnoses. We estimated Veteran's RAND 12-Item Short Form Survey Physical Component Summary (PCS) and Mental Component Summary (MCS) scores for all cohorts.

Results:

Our analysis found significantly higher mean MCS scores in the recent period for those with cancer relative to the recent noncancer control group. Breast and lung cancer presented positive and statistically significant trends. We found statistically insignificant differences in PCS scores between the two time periods. No cancer sites had different PCS scores over time compared with the comparison group.

Conclusions:

Mental health for those with cancer improved more between 2008 and 2019 than a matched noncancer comparison group. Physical health remained stable across time. These findings highlight the importance of including a matched noncancer group when evaluating HRQOL outcomes.

Impact:

SEER-MHOS respondents with cancer report stable PCS scores across 15 years of data and higher MCS scores relative to noncancer controls.
TABLE 3 from Maternal Embryonic Leucine Zipper Kinase is Associated with Metastasis in Triple-negative Breast Cancer
Authors: Xie Xuemei , Chauhan Gaurav B. , Edupuganti Ramakrishna , Kogawa Takahiro , Park Jihyun , Tacam Moises , Tan Alex W. , Mughees Mohd , Vidhu Fnu , Liu Diane D. , Taliaferro Juliana M. , Pitner Mary Kathryn , Browning Luke S. , Lee Ju-Hyeon , Bertucci François , Shen Yu , Wang Jian , Ueno Naoto T. , Krishnamurthy Savitri , Hortobagyi Gabriel N. , Tripathy Debu , Van Laere Steven J. , Bartholomeusz Geoffrey , Dalby Kevin N. , Bartholomeusz Chandra
Published: January 2024

Multicovariate Cox regression model for OS, PFS, and DMFS among patients with breast cancer (World IBC Consortium dataset; n = 314)
Supplementary Figure S2 from Maternal Embryonic Leucine Zipper Kinase is Associated with Metastasis in Triple-negative Breast Cancer
Authors: Xie Xuemei , Chauhan Gaurav B. , Edupuganti Ramakrishna , Kogawa Takahiro , Park Jihyun , Tacam Moises , Tan Alex W. , Mughees Mohd , Vidhu Fnu , Liu Diane D. , Taliaferro Juliana M. , Pitner Mary Kathryn , Browning Luke S. , Lee Ju-Hyeon , Bertucci François , Shen Yu , Wang Jian , Ueno Naoto T. , Krishnamurthy Savitri , Hortobagyi Gabriel N. , Tripathy Debu , Van Laere Steven J. , Bartholomeusz Geoffrey , Dalby Kevin N. , Bartholomeusz Chandra
Published: January 2024

Supplementary Figure S2. Volcano plots show differences in gene expression in parental and Cas9-p15 control or MELK knockout (KO) MDA-MB-231 cells.
TABLE 2 from Phase II Study of the Liposomal Formulation of Eribulin (E7389-LF) in Combination with Nivolumab: Results from the Small Cell Lung Cancer Cohort
Authors: Nishio Makoto , Murakami Shuji , Kawakami Hisato , Okishio Kyoichi , Tamiya Motohiro , Kobayashi Haruki , Fujimoto Daichi , Sugawara Shunichi , Kozuki Toshiyuki , Oya Yuko , Izumi Hiroki , Shiroyama Takayuki , Satouchi Miyako , Yamamoto Noboru , Kaname Shota , Matsuoka Daiko , Otake Yohei , Takase Takao , Semba Taro , Azuma Koichi
Published: January 2024

TEAEs that occurred in >10% of patients
TABLE 1 from Phase II Study of the Liposomal Formulation of Eribulin (E7389-LF) in Combination with Nivolumab: Results from the Small Cell Lung Cancer Cohort
Authors: Nishio Makoto , Murakami Shuji , Kawakami Hisato , Okishio Kyoichi , Tamiya Motohiro , Kobayashi Haruki , Fujimoto Daichi , Sugawara Shunichi , Kozuki Toshiyuki , Oya Yuko , Izumi Hiroki , Shiroyama Takayuki , Satouchi Miyako , Yamamoto Noboru , Kaname Shota , Matsuoka Daiko , Otake Yohei , Takase Takao , Semba Taro , Azuma Koichi
Published: January 2024

Patient demographics and baseline characteristics
Supplemental Table 4 from Phase II Study of the Liposomal Formulation of Eribulin (E7389-LF) in Combination with Nivolumab: Results from the Small Cell Lung Cancer Cohort
Authors: Nishio Makoto , Murakami Shuji , Kawakami Hisato , Okishio Kyoichi , Tamiya Motohiro , Kobayashi Haruki , Fujimoto Daichi , Sugawara Shunichi , Kozuki Toshiyuki , Oya Yuko , Izumi Hiroki , Shiroyama Takayuki , Satouchi Miyako , Yamamoto Noboru , Kaname Shota , Matsuoka Daiko , Otake Yohei , Takase Takao , Semba Taro , Azuma Koichi
Published: January 2024

Supplementary Table 4. Median Change in Biomarkers from Baseline
Supplemental Figure 3 from Phase II Study of the Liposomal Formulation of Eribulin (E7389-LF) in Combination with Nivolumab: Results from the Small Cell Lung Cancer Cohort
Authors: Nishio Makoto , Murakami Shuji , Kawakami Hisato , Okishio Kyoichi , Tamiya Motohiro , Kobayashi Haruki , Fujimoto Daichi , Sugawara Shunichi , Kozuki Toshiyuki , Oya Yuko , Izumi Hiroki , Shiroyama Takayuki , Satouchi Miyako , Yamamoto Noboru , Kaname Shota , Matsuoka Daiko , Otake Yohei , Takase Takao , Semba Taro , Azuma Koichi
Published: January 2024

Supplementary Figure 3. Changes from Baseline in Additional Vasculature- and IFNγ-related Biomarkers Weekly to C3D1 (A), and Per Cycle to C8D1 (B)
Supplemental Figure 1 from Phase II Study of the Liposomal Formulation of Eribulin (E7389-LF) in Combination with Nivolumab: Results from the Small Cell Lung Cancer Cohort
Authors: Nishio Makoto , Murakami Shuji , Kawakami Hisato , Okishio Kyoichi , Tamiya Motohiro , Kobayashi Haruki , Fujimoto Daichi , Sugawara Shunichi , Kozuki Toshiyuki , Oya Yuko , Izumi Hiroki , Shiroyama Takayuki , Satouchi Miyako , Yamamoto Noboru , Kaname Shota , Matsuoka Daiko , Otake Yohei , Takase Takao , Semba Taro , Azuma Koichi
Published: January 2024

Supplementary Figure 1. Patient Disposition
FIGURE 4 from Phase II Study of the Liposomal Formulation of Eribulin (E7389-LF) in Combination with Nivolumab: Results from the Small Cell Lung Cancer Cohort
Authors: Nishio Makoto , Murakami Shuji , Kawakami Hisato , Okishio Kyoichi , Tamiya Motohiro , Kobayashi Haruki , Fujimoto Daichi , Sugawara Shunichi , Kozuki Toshiyuki , Oya Yuko , Izumi Hiroki , Shiroyama Takayuki , Satouchi Miyako , Yamamoto Noboru , Kaname Shota , Matsuoka Daiko , Otake Yohei , Takase Takao , Semba Taro , Azuma Koichi
Published: January 2024

Changes from baseline in select vasculature and IFN-related biomarkers weekly to C3D1 (A), per cycle to C8D1 (B), by tumor response (for vasculature-related biomarkers; C), and by presence of prior ICI treatment (for IFN-related biomarkers; D). Lines represent medians; error bars represent 95% CI. For box-and-whisker plots in C, the horizontal line represents the median, the box represents the interquartile range, the whiskers represent the largest or smallest values within 1.5 times the interquartile range (either above the 75th percentile or below the 25th percentile), and diamonds represent outliers. P values are: *, P < 0.05; **, P < 0.01; ***, P < 0.001; patient numbers are as follows: A: n = 33 (C1D1, C1D8), n = 32 (C1D15), n = 30 (C2D1), n = 29 (C2D8), n = 28 (C2D15), n = 25 (C3D1). B: n = 33 (C1D1). n = 30 (C2D1), n = 25 (C3D1), n = 24 (C4D1), n = 19 (C5D1), n = 12 (C6D1), n = 8 (C7D1), n = 7 (C8D1). C: for CR/PR, n = 8 (C2D1, C3D1, C4D1); for non-CR/PR, n = 22 (C2D1), n = 17 (C3D1), n = 16 (C4D1). D: for prior ICI, n = 27 (C1D1, C1D8), n = 26 (C1D15), n = 25 (C2D1, C2D8, C2D15), n = 20 (C3D1); for no prior ICI, n = 6 (C1D1, C1D8, C1D15), n = 5 (C2D1), n = 4 (C2D8), n = 3 (C2D15), n = 5 (C3D1). C#D#, cycle #, day; CR, complete response; ICI, immune checkpoint inhibitor; IFNγ, interferon gamma; IP-10, IFN gamma-induced protein 10; MIG, monokine induced by gamma IFN; PECAM1, platelet endothelial cell adhesion molecule 1; PR, partial response; TEK, TEK receptor tyrosine kinase; TIE2, tyrosine kinase immunoglobulin and EGF homology domains 2.
FIGURE 1 from Phase II Study of the Liposomal Formulation of Eribulin (E7389-LF) in Combination with Nivolumab: Results from the Small Cell Lung Cancer Cohort
Authors: Nishio Makoto , Murakami Shuji , Kawakami Hisato , Okishio Kyoichi , Tamiya Motohiro , Kobayashi Haruki , Fujimoto Daichi , Sugawara Shunichi , Kozuki Toshiyuki , Oya Yuko , Izumi Hiroki , Shiroyama Takayuki , Satouchi Miyako , Yamamoto Noboru , Kaname Shota , Matsuoka Daiko , Otake Yohei , Takase Takao , Semba Taro , Azuma Koichi
Published: January 2024

Percentage changes in sums of diameters of target lesions from baseline over time (A)a, and by PD-L1 CPS at nadir in all patients (B), patients with a biopsy (C), and patients with an archival tumor sample (D) aPatients could continue to receive study drugs beyond disease progression if they had investigator-assessed clinical benefit and were tolerating study drugs. A includes data from beyond disease progression. CPS, combined positive score; ICI, immune checkpoint inhibitor; N/A, not available; PD-L1, programmed cell death ligand 1.
A Dramatic Response to Second-Line Nivolumab and Ipilimumab in BRAF-V600-Mutated Metastatic Melanoma
Authors: Fedele Dahlia , Moroso Stefano , Turoldo Angelo , Bazzocchi Gabriele , Conforti Claudio , Zalaudek Iris , Guglielmi Alessandra
Published: January 2024

Introduction: Current treatment options for BRAF V600-mutated unresectable stage III/IV melanoma include anti-PD-1 monotherapy or combination with anti-CTLA-4 or anti-LAG-3 agents, BRAF/MEK inhibitors, and clinical trials. The strategy of combination immunotherapy with nivolumab and ipilimumab has shown promising results, achieving higher response rates, longer duration of response, improved progression-free survival, and enhanced overall survival. The optimal sequence of treatments remains a topic of interest, with preliminary data suggesting a greater effectiveness of immunotherapy as the first-line approach. Preclinical trials have indicated that the efficacy of this sequence may be due to the modification of the immune environment by BRAF kinase inhibitors, leading to immune escape by tumor cells and resistance to immune checkpoint inhibitors. Case Presentation: We present a case of a 72-year-old woman with high-burden metastatic melanoma who failed to respond to prior targeted therapy with BRAF/MEK inhibitors and exhibited a successful response to the second-line treatment with ipilimumab and nivolumab. We discuss the potential reasons for this positive outcome contributing to the current debate concerning treatment sequences, resistance mechanisms, and biomarkers predictive of response to immune checkpoint inhibitors in metastatic melanoma. Conclusion: We believe that in few years the therapeutic algorithms in BRAF V600-mutated unresectable stage III/IV melanoma will be more complex since they will define clearly the correct therapeutic sequences with the inclusion of new immune checkpoint inhibitor drugs and multiple predictive biomarkers of response to better select patients eligible to immunotherapy.
Genetic Variants Associated with Hypertension Risk: Progress and Implications
Authors: Curtis David
Published: January 2024

Background: Genetic variants causing diseases with hypertension as a secondary feature have previously been identified. Studies focussing on primary hypertension have utilised common and latterly rare genetic variants in attempts to elucidate the genetic contribution to the risk of primary hypertension. Summary: Using genome-wide association studies (GWASs), associations of hypertension with hundreds of common genetic variants have been reported, implicating thousands of genes. Individual variants have small effect sizes and cumulatively account for around 6% of genetic risk. The common variant signal is enriched for relevant tissues and physiological processes, while some variants are associated with traits expected to have secondary impacts on hypertension risk, such as fruit intake, BMI, or time watching television. Studies using rare variants obtained from exome sequence data have implicated a small number of genes for which impaired function has moderate effects on blood pressure and/or hypertension risk. Notably, genetic variants which impair elements of guanylate cyclase activation, stimulated by either natriuretic hormones or nitric oxide, increase hypertension risk. Conversely, variants impairing dopamine beta-hydroxylase or renin production are associated with lower blood pressure. Variants for which a definite effect can be designated remain cumulatively extremely rare and again make only a small contribution to overall genetic risk. Although these results are of interest, it is not clear that they provide radical new insights or identify drug targets which were not previously known. Nor does it seem that genetic testing could be useful in terms of quantifying disease risk or guiding treatment. Key Messages: Research has increased our knowledge about the relationship between naturally occurring genetic variation and risk of hypertension. Although some results serve to confirm our understanding of underlying physiology, their value in terms of potentially leading to practical advances in the management of hypertension appears questionable.
Соціально-етичні портрети представників духовенства в Новгородському першому літописі
Authors: Межжеріна [Mezhzherina] Ганна Валентинівна [Hanna Valentynivna]
Published: January 2024

Socio-Ethical Portraits of Representatives of the Clergy in the Novgorod First Chronicle
The article is devoted to the reconstruction of the corpus of socio-ethical portraits of representatives of the clergy (преставися блаженыи митрополит, боголюбивым архиепископомъ Феоктистомъ) in the Novgorod First Chronicle. As examined, the chronicle entries of the eleventh–thirteenth centuries contain portraits of eleven clergymen – metropolitans of Kyiv and Novgorod, archbishops, bishops, abbots (Stephen Domesticus, Sava Grechin, Cyril I, Niphont, Anthony, Martirii, Arsenii, Theoktist and others). The study established that the use of laudatory epithets is a way of expressing the political position of representatives of the secular and ecclesiastical authorities. The author’s self-awareness of the chronicler, his desire to express his own opinion, without going beyond the canons of chronicles and norms of literary etiquette, found manifestation in the use of epithets. The degree of objectivity of the annalistic assessment and the degree of etiquette in the use of epithets next to the names of real historical figures have been examined using a combination of linguistic analysis with historical and cultural analysis, taking into account historical facts.
Społeczno-etyczne portrety przedstawicieli duchowieństwa w Latopisie nowogrodzkim pierwszym
Artykuł jest poświęcony rekonstrukcji korpusu portretów społeczno-etycznych przedstawicieli duchowieństwa (преставися блаженыи митрополит, боголюбивым архиепископомъ Феоктистомъ) w Latopisie nowogrodzkim pierwszym. Jak ustalono, zapisy kronikarskie z XI–XIII wieku zawierają portrety jedenastu duchownych – metropolitów kijowskich i nowogrodzkich, arcybiskupów, biskupów, opatów (Stefan Domestyk, Sawa Greczin, Cyryl I, Nifont, Antoni, Martirij, Arsenij, Teoktyst i in.). W toku badań stwierdzono, że stosowanie epitetów pochwalnych jest sposobem wyrażania stanowiska politycznego przedstawicieli władzy świeckiej i kościelnej. Samoświadomość autora kroniki, chęć wyrażenia własnego zdania bez wykraczania poza kanony kronikarskie i normy etykiety literackiej przejawiają się w stosowaniu epitetów. Zbadano stopień obiektywizmu oceny kronikarskiej i wymogów etykiety w wyborze epitetów przy imionach rzeczywistych postaci historycznych, łącząc analizę językoznawczą z analizą historyczno-kulturową, z uwzględnieniem faktów historycznych.
GeoXO: NOAA’s Future Geostationary Satellite System
Authors: Lindsey Daniel T. , Heidinger Andrew K. , Sullivan Pamela C. , McCorkel Joel , Schmit Timothy J. , Tomlinson Michelle , Vandermeulen Ryan , Frost Gregory J. , Kondragunta Shobha , Rudlosky Scott
Published: January 2024

Geostationary Extended Observations, or GeoXO, is NOAA’s future geostationary satellite constellation, set to launch in the early 2030s and operate into the 2050s. Given changes to the Earth system, improvements in technology, and expanding needs of satellite data users, GeoXO will extend NOAA’s current observation suite by adding three new instruments and one new spacecraft. Improved versions of the imager and lightning mapper will again be placed on East and West satellites, where they will monitor severe storms, tropical cyclones, fires, and other hazards. They will be joined by an ocean color instrument designed for detection of harmful algal blooms, phytoplankton, chlorophyll-a, and other constituents. The third geostationary spacecraft will be placed in the center of the United States and will carry a hyperspectral infrared sounder, an atmospheric composition instrument, and potentially a partner payload. Radiances from the sounder will be assimilated into numerical weather prediction models to improve forecasts, and sounder-derived retrievals of vertical profiles of temperature and water vapor will allow forecasters to detect and track areas of enhanced instability. Retrievals of pollutants such as nitrogen dioxide and ozone from the new atmospheric composition instrument along with trace gas measurements from the sounder will be used to improve air quality monitoring, forecasts, and warnings in addition to climate monitoring. Once complete, the GeoXO constellation will contribute to an international “geo ring” of satellites that will be used for worldwide weather, oceans, climate, and air quality monitoring. This revolutionary new geostationary satellite constellation will provide critical observations for a changing Earth system.
Visualized values on Instagram: A comparison of visual practices among German and Ukrainian Instagram users
Authors: Bataeva Ekaterina
Published: January 2024

This article focuses on the similarities and differences between visual value content on German and Ukrainian Instagram, employing the methodology of traditional, modernist, and postmodernist values. In particular, we investigate the gender aspect of visualized values on Instagram in a cross-cultural comparative perspective. The results of content analysis of 2095 photos on German Instagram and 2657 photos on Ukrainian Instagram reveal that most often, in the social practices of Ukrainian and German Instagram users, modernist and postmodernist values are visualized. Our findings support the argument that Instagram is a specific field of social practices that contributes to the unification of the visual practices of users and the homogenization of the visualized values as a result of cultural convergence.
Fatigue performance investigation of perforated and bolted pultruded glass fiber reinforced polymer laminates based on experiment and digital images
Authors: Xiong Zhihua , Meng Yang , Zhao Chenyu , Liu Yuqing , Liu Xiaoyu
Published: January 2024

To investigate the fatigue performance of perforated and bolted pultruded Glass Fiber Reinforced Polymer (GFRP) laminates, a series of tests are conducted including static tensile and cyclic fatigue test, while Digital Image Correlation (DIC) and CT tests were implemented to monitor strains around the perforations and damage developed in the samples subjected to tensile and fatigue tests respectively. The stress concentrations of the cyclic loaded perforated GFRP laminates are discussed based on the experiment results. Due to the stress limitation of single bolted laminates, the diameter to width ratio is suggested to be less than 0.3. The GFRP laminates with double holes have a better fatigue performance than that of single hole, which is called the double-hole effect. This effect is also found in double bolted GFRP laminates. Considering the strength of the laminates between the holes and to unify the requirement, the critical distance to width ratio is suggested to be 1.6 and the diameter to width ratio should be less than 0.3.
Sjögren’s Disease and Oral Health: A Genetic Instrumental Variable Analysis
Authors: Reckelkamm S.L. , Alayash Z. , Holtfreter B. , Nolde M. , Baumeister S.E.
Published: January 2024

Epidemiological studies have consistently shown that Sjögren’s disease (SjD) increases the risk of dental caries. Despite similar evidence indicating an elevated risk of periodontitis, SjD remains a disputed risk factor for this disease. The risk of bias in observational research is a major impediment to confirming this link. Within an instrumental variable framework, genetic variants associated with a risk factor can be used to proxy its effect on an outcome while avoiding common sources of observational study bias. In this study, we leveraged an instrumental variable approach to investigate whether SjD affects the risk of caries and periodontitis. A total of 57 genetic variants strongly associated with SjD were identified from a genome-wide association study of 2,247 European descent cases and 332,115 controls. We tested for associations of these genetic instruments with caries (measured as the number of decayed, missing, and filled surfaces in 26,792 individuals) and periodontitis (17,353 clinical periodontitis cases and 28,210 European controls). Several sensitivity analyses were used to further validate the primary inverse variance weighted (IVW) estimate. IVW analysis revealed an adverse effect of SjD on caries (β = 0.039, P = 6.3e-16) and periodontitis (odds ratio = 1.033, P = 2.3e-05). Sensitivity analyses, conducted to assess the robustness to potential violations of instrumental variable assumptions, further support these findings. Our results showed that SjD has a detrimental effect on caries and also suggest that SjD promotes periodontitis.