bluuebunny/crossref_metadata_2025 huggingface dataset:
Küreselleşme ve Göç: Yerel Gazetecilerin Göç Olgusuna Bakış Açısının Değerlendirilmesi
Authors: Adıyaman Fırat , Sarıgül Ali , Sezek Aslıhan , Yılmaz Kübra , Kaya Hatice
Published: July 2024

Küreselleşme, göçü şekillendiren ve hızlandıran bir unsura dönüşmektedir. Küresel sermaye hareketlerinin yer değiştirmesi, bölgesel savaşlar ve daha iyi bir yaşam arayışına yönelik arayışın teknolojiyle kesişmesi göç olgusunu, küresel kamuoyunun önemli gündem maddelerinden biri hâline getirmiştir. Ülkelerin durdurmakta güçlük çektiği insan hareketleri, sınırları zorlamaya devam etmektedir. Küresel ölçekte artışa geçen göçün ekonomik ve toplumsal sonuçlarıyla daha çok yereldeki insanlar karşılaşmaktadır. Medya, göç konusunun birçok açıdan tartışıldığı bir alan olarak kamuoyunun şekillenmesinde önemli bir araçtır. Benzer şekilde yerel medya, küresel bir sorun olan göç sorunun farklı açılardan ele alındığı bir alandır. Daha çok yerel olayların haberleştirildiği yerel medyada, küresel olaylar da kaçınılmaz bir şekilde ele alınmaktadır. Göç konusu da yerel medyanın önem verdiği konular arasına girmiştir. Bu bağlamda yerel gazetecilerin göç konusu hakkındaki düşüncelerinin ne olduğu çalışmanın problemini oluşturmaktadır. Bu çalışmanın amacı, küreselleşme bağlamında yerel gazetecilerin göç olgusuna nasıl yaklaştığını belirlemektir. Ayrıca çalışmada yerel gazetecilerin küreselleşme, ekonomi, sosyokültürel ve medya hakkındaki düşünceleri analiz edilmektedir. Çalışmada, nitel araştırma desenlerinden fenomenoloji uygulanmıştır. Çalışmada veri toplama tekniği olarak derinlemesine görüşmeler, gerçekleştirilmiştir. Elde edilen bulgulara göre küreselleşme başlığında gazetecilerin düşüncelerinde ön plana çıkan temalar; küresel güçlerin göçlere neden olduğu, iletişim alanındaki gelişmelerin küresel göçlerde etkide bulunduğu, göçlerin ucuz iş gücü oluşturduğu ve küresel göç yönetiminin adil olmadığı şeklindedir.
Trend analysis of precipitation and drought characteristics over Churu district of northeast Rajasthan, India
Authors: Patel Shahid , Mehta Darshan , Kumar Vijendra , Patel Shakera , Tiwari Deepak Kumar
Published: July 2024

Drought is one of the most destructive natural disasters, becoming more extreme and less predictable due to climate change. Drought directly affects a region's water resources, leading to inadequate water availability and harming crops, animals, and humans. The objective of the present study is to assess the long-term trends of precipitation and drought characteristics for the Churu district of northeast Rajasthan, India. For this purpose, mean monthly precipitation data are collected through the India-WRIS from 1901 to 2022. The trend analysis uses statistical methods (M-K test & amp; SS estimator), and the results are compared with a graphical method (innovative trend analysis). Drought events are found using precipitation-based drought indices, i.e., standardized precipitation index, Z-score index, and percentage of normal precipitation index. Interestingly, the results of the statistical method are well matched with the results of the graphical method. The study concludes that during the annual precipitation a rising trend is observed, which can help to mitigate the severity of drought. Also, it is found that moderately dry droughts occur most frequently compared with other drought events. This study will help policy-makers and local administrators to take necessary action to mitigate the severity of drought.
MicroRNA-605-3p Inhibited the Growth and Chemoresistance of Osteosarcoma Cells via Negatively Modulating RAF1
Authors: Wang Mao , Li Weina , Han Guohui , Bai Xiangdong , Xie Jun
Published: July 2024

Background:

Osteosarcoma (OS) is the leading cancer-associated mortality in
childhood and adolescence. Increasing evidence has demonstrated the key function of microRNAs
(miRNAs) in OS development and chemoresistance. Among them, miRNA-605-3p acted as an
important tumor suppressor and was frequently down-regulated in multiple cancers. However, the
function of miR-650-3p in OS has not been reported.

Objective:

The aim of this work is to explore the novel role of miR-605-3p in osteosarcoma and its
possible involvement in OS chemotherapy resistance.

Methods:

The expression levels of miR-605-3p in OS tissues and cells were assessed by reverse
transcription quantitative PCR (RT-qPCR). The relevance of miR-605-3p with the prognosis of OS
patients was determined by the Kaplan-Meier analysis. Additionally, the influence of miR-605-3p
on OS cell growth was analyzed using the cell counting kit-8, colony formation assay, and flow
cytometry. The mRNA and protein expression of RAF1 were detected by RT-qPCR and western
blot. The binding of miR-605-3p with the 3’-UTR of RAF1 was confirmed by dual-luciferase
reporter assay.

Results:

Our results showed that miR-605-3p was markedly decreased in OS tissues and cells. A
lower level of miR-605-3p was strongly correlated with lymph node metastasis and poor 5-year
overall survival rate of OS patients. In vitro assay found that miR-605-3p suppressed OS cell
proliferation and promoted cell apoptosis. Mechanistically, the proto-oncogene RAF1 was seen as
a target of miR-605-3p and strongly suppressed by miR-605-3p in OS cells. Restoration of RAF1
markedly eliminated the inhibitory effect of miR-605-3p on OS progression, suggesting RAF1 as a
key mediator of miR-605-3p. Consistent with the decreased level of RAF1, miR-605-3p
suppressed the activation of both MEK and ERK in OS cells, which are the targets of RAF1.
Moreover, lower levels of miR-605-3p were found in chemoresistant OS patients, and downregulated
miR-605-3p increased the resistance of OS cells to therapeutic agents.

Conclusion:

Our data revealed that miR-605-3p serves as a tumor suppressor gene by regulating
RAF1 and increasing the chemosensitivity of OS cells, which provided the novel working
mechanism of miR-605-3p in OS. Engineering stable nanovesicles that could efficiently deliver
miR-605-3p with therapeutic activity into tumors could be a promising therapeutic approach for the
treatment of OS.
Knockdown of Anoikis-Associated Gene OCIAD2 Reduces Proliferation and Migration of Glioblastoma Cell Lines
Authors: Huang Danna , Chen Lu , Liu Yu , Wu Wuwei , Liu Yingying , Pan Yu
Published: July 2024

Background:

Glioblastoma (GBM) severely disrupts the quality of life of patients.
Anoikis represents a significant mechanism in cancer invasion and metastasis. Our study focused
on the prognostic relationship between the anoikis-associated gene and GBM and its effect on
GBM cell progression.

Methods:

We downloaded 656 and 979 GBM sample data from TCGA and CGGA cohort datasets,
respectively. Fifteen anoikis-associated genes were obtained from the GeneCards database
and were subsequently clustered to identify differential genes associated with them. After
LAASO screening, the expression values of the 5 differential genes were the sum of LASSO regression
coefficients. Survival analysis and ROC curve analysis of anoikis scores were performed
using the TCGA training and CGGA validation sets. The prognostic factors were analyzed
using Cox regression analysis in GBM. Moreover, CCK-8, colony formation, wound healing,
and transwell assay were used to evaluate GBM cell proliferation and migration.

Results:

Significant differences were observed in the 5-year survival of GBM patients between
the two subgroups. Then, our analysis demonstrated that high OCIAD2, FTLP3, IGFBP2, and
H19 levels were associated with lower 5-year GBM survival rates, whereas high SFRP2 levels
were associated with higher survival rates. Univariate Cox analysis indicated that GBM risk was
linked to both anoikis score and grade, while multivariate Cox analysis indicated that GBM risk
was associated with both anoikis score and age. Additionally, OCIAD2 was highly expressed in
U251MG and T98G cells. Moreover, OCIAD2 silencing inhibited GBM cell proliferation and
migration.

Conclusion:

This study demonstrated the potential of the anoikis-associated gene OCIAD2 as a
prognostic biomarker for GBM. Furthermore, we validated in vitro that OCIAD2 promoted
GBM cell progression.
Synthesis, Characterization, Molecular Docking, and Molecular Dynamics Studies of Schiff Bases of 2-Phenoxy-1-Phenyl-Ethanone as Antibacterial Agents
Authors: Agrawal Akarsh , Sati Nitin , Kumar Arvind , Kumar Sushil
Published: July 2024

Background:

The development of antimicrobial resistance and reduced discovery and commercialization of newer antibiotics point to the need for the discovery of novel anti-bacterial agents. Schiff bases are reported to possess a broad range of pharmacological activi-ties, which also include antibacterial activity. With this background, novel Schiff bases were synthesized.

Aim:

The present study aimed to synthesize novel Schiff bases of 2-phenoxy-1-phenyl-etha-none with aryl amines and evaluate their antibacterial activity.

Methods:

The desired Schiff bases were synthesized by condensing various aryl amines with 2-bromo-1-phenylethanone and characterized by physicochemical and spectral methods. The antibacterial activity of the synthesized Schiff bases was determined by the cup diffusion method. Molecular docking with Staphylococcus aureus tyrosyl-t-RNA synthetase (Protein Data Bank ID: 1JIJ) was performed using Autodock. Molecular dynamics simulation studies were performed using GROMACS. ADME analysis and drug-likeliness of the synthesized compounds were predicted using SwissADME. Protein-ligand interactions were studied using BIOVIA Discovery Studio Visualizer.

Results:

Out of the synthesized compounds, two compounds, sb_04 and sb_05, exhibited fair antibacterial activity. The compounds sb_04 and sb_05 exhibited better binding energy values than the original ligand of the target enzyme and comparable binding energy with ampicillin. The Autodock program estimated the binding free energy and inhibition constant values of compound sb_05 as -9.18 kcal/mol and 187.33 nM and for the compound sb_04 as -8.82 kcal/mol and 341.59 nM, respectively. The RMSD values of the compound sb_04 were stable throughout the duration of the simulation; however, the compound sb_05 showed lesser sta-bility in the docked complex. Interestingly, the compound sb_05 (-182.754 kJ/mol) exhibited stable interaction with a lower value of total interaction energy than sb_04 (-136.304 kJ/mol). The synthesized Schiff bases showed no violation of Lipinski’s rule of five and a bioavailabil-ity score in the range of 55% to 85%.

Conclusion:

The synthesized Schiff bases present a scaffold for the development of novel antibacterial agents, in particular the compounds sb_04 and sb_05.
Experiences of Discrimination and its Impact on the Intensity of Pain: A Study in the Elderly Brazilian Population
Authors: Zarama Virginia ,   Facultad de Ciencias de la Salud, Universidad ICESI, Cali, Colombia, Crasta Nikitha , Sosa Jeltsina , Gomez Kimberly P. , Fernández Daniela M. , García José , de Magalhaes Silviane Fernandes , Montoya Marco ,   Department of Emergency Medicine, Fundación Valle del Lili, Cali, Colombia,   Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States,   Universidad Iberoamericana (UNIBE), Santo Domingo, República Dominicana,   Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida, United States,   Fundación Universitaria San Martin, School of Medicine, Bogotá, Colombia,   Facultad de Medicina, Universidad Francisco Marroquín,   Universidad Iberoamericana (UNIBE), Santo Domingo, República Dominicana,   Eurofarma Laboratórios S.A.,   Department of Dermatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States
Published: July 2024

Background: The experience of pain is multifactorial and may be exacerbated by everyday stressors like discrimination leading to a poor quality of life. Perceived discrimination has been associated with the presence and increased intensity of pain. The elderly population may be more likely to experience discrimination making them vulnerable to external stress factors that can make managing pain more difficult. We aimed to explore the influence of discrimination and stress on pain intensity in an elderly Brazilian population. Methods: In this cross-sectional study design, we analyzed the data from the Brazilian Longitudinal Study of Aging (ELSI- Brazil) in which participants answered the revised everyday discrimination questionnaire stating their pain intensity and perceived stress level. The effect of discrimination and stress on pain intensity was assessed using a multivariable-adjusted ordinal logistic regression. Sensitivity analysis with multiple imputations for missing data was also conducted to assess the robustness of the findings. Results: In the elderly Brazilian population, discrimination and perceived stress had a significant association with pain intensity. The odds of experiencing strong intense pain were 7% higher in an adult experiencing everyday discrimination (OR= 1.07, 95% CI: 1.03-1.11, p<0.001). Stress was also significantly associated with pain intensity (OR 1.05, 95% CI 1.05 - 1.06). This finding emphasizes the need to address the influence of such societal factors on the psychological and physical aspects of pain. Conclusion: Our study found that there is a significant association between experiences of discrimination and stress with pain intensity in a large population from Brazil in accordance with previous studies despite differences in population demographics and cultural contexts. These findings provide evidence of the generalizability of these associations and underscores the detrimental health consequences associated with perceived discrimination.
Intangible benefits as objects of civil law protection
Authors: Popova I. Y.
Published: July 2024

Relevance. The article analyzes legislative provisions and views of Russian scientists on the issues of protection of intangible benefits, definition of their signs, classification criteria, strengthening of protection, establishment of correlation between intangible benefits and personal non-property rights. The peculiarities of protection of intangible benefits in those areas in which such protection is most in demand at present, including the protection of honor, dignity and business reputation of citizens, their images, consumer rights, compensation for moral harm associated with encroachments on life and health, and in other cases are considered.

The conclusions are made about the need for further development of the system of civil legal protection of intangible benefits, which is currently in the stage of formation, based on the generalization and systematization of existing approaches, as well as the development of the definition of the concept of intangible benefits, their scientifically justified classification, division by types, including taking into account the features of their protection.

The purpose of the study is to develop theoretical provisions aimed at improving the civil legal protection of intangible benefits.

Objectives: to analyze the peculiarities of legal relations arising in connection with violations of intangible benefits and encroachments on such intangible benefits; to identify problems arising in the protection of intangible benefits by civil law means; to propose solutions that ensure the elimination of gaps and contradictions in the legislation related to the protection of intangible benefits.

Methodology. In the research we used general scientific methods, including dialectical-materialistic method, methods of analysis and synthesis, etc., as well as systematic and formal-legal methods.

The results of the research have a theoretical and applied nature and are aimed at improving the legal regulation of relations related to the protection of intangible benefits.

Conclusions. For further development of the legislation and judicial practice it is required to develop a scientifically grounded classification of intangible benefits, based on the identification of their signs and features, as well as to determine the features of protection methods applicable to encroachments on intangible benefits, which will allow to extend such protection to all cases of violations and encroachments on intangible benefits.
Civil protection of a citizen's privacy after his death
Authors: Ustinov V. D. , Korotkich O. A.
Published: July 2024

Relevance. The article considers the peculiarities of civil protection of a person's private life after his death by other persons in accordance with Art. 152.2 of the Civil Code of the Russian Federation. The positions of legal scholars regarding the ambiguous phenomenon of «experience of law» with the inalienability of intangible benefits, when information about the private life of a deceased citizen is subject to posthumous protection, are analyzed. The established judicial practice was studied to resolve such claims for civil law remedies for the right to privacy of a deceased person, decisions of the Constitutional Court and clarifications of the Supreme Courts of the Russian Federation on issues related to the protection of the personal non-property law in question in civil proceedings.

The purpose of the study is to supplement theoretical provisions deepening the civil law theory of posthumous protection of privacy, and to develop proposals to eliminate existing gaps in civil ¬ legal regulation in this area.

Objectives: to analyze court decisions on claims for posthumous protection of private life, decisions of the Constitutional Court and decisions of the Supreme Courts of the Russian Federation, to identify shortcomings in the wording of Art. 152.2 of the Civil Code of the Russian Federation, as well as to update, taking into account scientific discussions, proposals regarding the sale of intangible benefits after death.

Methodology. To achieve a theoretical and practical result, the author used scientific (analysis, synthesis, induction and deduction) and private scientific methods (formal-legal, system-analytical and formal-logical, method of analysis and generalization of judicial practice).

The results of the study are determined by its theoretical and applied nature and contain the author's vision of improving the norms of the Civil Code of the Russian Federation in terms of posthumous protection of the right to privacy (changing the list of persons entitled to protect the interests of the deceased, legalizing the concept of «good memory of a deceased citizen»).

Conclusion. Posthumous protection of privacy is delegated by the state to close relatives of the deceased person by virtue of public and personal interest. In connection with death, the legal personality of a person ceases, and those who protect the privacy of the deceased become the subjects of legal relations.
The concept of an ideocratic state
Authors: Safronov N. A.
Published: July 2024

Relevance.It is quite obvious that the modern world has entered a new stage of its development, the prospects of which are very vague. The model of the mondial world order with its ideas of faceless globalization, depopulation, universalization, de-Christianization, etc. are rejected by Russia. Recently, in political discourse and in official strategic planning documents, Russia has been called a civilization state with a pronounced identity. In the Russian conservative legal doctrine, the definition of specific features of Russia's state identity was a key topic, and the priority of intangible values was noted as the main feature of Orthodox civilization. It is no coincidence that Russian socio-political thought has always been puzzled by the search for a Russian idea. In this regard, the concept of ideocratic statehood is of particular interest, the main meaning of which was to search for a key idea or system of ideas on the basis of which the state should be built.

The aimis to reconstruct and interpret the theory of the ideocratic state of the Russian conservative political and legal doctrine of the late XIX - first half of the XX centuries.

Research objectives:to study the evolution of the concept of an ideocratic state, to analyze its conceptual apparatus, to comprehend the importance of state ideology for the modern stage of development.

Methodology.It is based on the historical method of cognition, which contributed to the disclosure of the evolution of the theory under study, the method of diachronic and synchronous comparison, as well as a problem-theoretical one, which allows determining the degree of modern relevance of the concept under study.

Results.The conducted research allowed us to establish that the concept of ideocratic statehood was mainly formed in the works of representatives of the socio-political movement of Eurasians, which originated in the 20-30 years among Russian emigration. The most significant contribution to the theoretical development of the doctrine of the ideocratic state was made by N.N. Alekseev. It was he who generalized the ideas of the Eurasians, conceptualizing them into a legally sound theory of demotic ideocracy or a guarantee state.

Conclusion.Ideocracy is a concept of governance based on the postulate of idealism, based on which the definition of the state as a single super-organic entity, where the idea shared by all the people rules.
The abolition of serfdom and the situation of the post-Reform peasantry in Russia in the assessments of V. P. Meshchersky
Authors: Ipatov A. M. , Oboimova R. V.
Published: July 2024

Relevance. The article attempts to present an assessment by the influential conservative publicist and publicsher of the magazine "Citizen" V. P. Meshchersky of the events of the abolition of serfdom and the post-reform situation of the Russian peasantry. Turning to the study of this question allows us to expand the understanding of existing opinions about the problem under study.

The purpose of the study is to analyze, on the basis of modern achievements of historical science, the assessments of the abolition of serfdom and the post-reform status of the peasantry by the influential Russian publicist V. P. Meshchersky.

Objectives: to analyze the sources and historiography on the topic under study; to focus on the socio-political views of Prince V. P. Meshchersky and their uniqueness, or, on the contrary, typical for the environment of domestic conservatives of the second half of the XIX century; to try to reconstruct, on the basis of his assessments, the perception by an influential publicist of the events of the abolition of serfdom and the prevailing post-reform situation of the peasantry.

Methodology. The presented research is based on the principles of historicism, objectivity, consistency, which are closely interrelated with the dialectical method, as well as on general scientific methods of analysis, synthesis and generalization.

Results. The conducted research allowed us to focus on the significant interest of Prince V. P. Meshchersky in the peasant issue, the abolition of serfdom and its practical implementation. At the same time, remaining a representative of the noble class, he largely expressed his thoughts on the post-reform situation of the peasantry from the point of view of the interests of landowners, emphasizing that in conditions of political immaturity of the broad masses of the population and lack of experience in independent economic activity, many peasants are waiting for ruin and impoverishment.

Conclusion. Vladimir Petrovich Meshchersky's views on the abolition of serfdom and the post-reform situation of the peasantry mostly coincided with the opinions of other representatives of the conservative camp, except for the editorial office of the newspaper "Vesti". They were largely the result of his worldview on the paternalistic nature of relations between landlords and serfs, so the prince, being a staunch supporter of the liberation of the peasants, was dissatisfied with its implementation in practice. He based his conclusions on what he saw during numerous trips around the country.
The organization of provincial control bodies in 1920-1922: based on the materials of the Kursk region
Authors: Nemkova D. S.
Published: July 2024

Relevance. In modern conditions, the main directions of reforming control (supervisory) activities are to increase its efficiency and effectiveness, reduce the administrative burden on enterprises and entrepreneurs. The improvement of control (supervisory) activities remains relevant in the context of increased external sanctions pressure. At the same time, the history of the control system, which extended to all types and forms of public administration and economic activity, remains poorly understood in terms of existing regional experience. The study of the formation of control bodies in the Soviet state is of particular practical interest, since it allows accumulating achievements and mistakes of the past, thereby setting benchmarks in the present.

Purpose. The study of the experience of organizing socialist control bodies in 1920-1922 on the example of the Kursk provincial branch of the Workers' and Peasants' Inspection.

The objectives of the article follow from the set goal and consist in investigating the conditions and methods of work of the Kursk provincial department of the Workers' and Peasants' Inspection during the designated period.

Methodology. During the research of the designated topic, the author used both general scientific methods of cognition, such as analysis, synthesis, induction, deduction, and special historical methods: problem-chronological, comparative historical.

Results. The study of the working conditions of the Kursk provincial department of the Workers' and Peasants' Inspection in the designated period allowed, in historical retrospect, to determine the specifics of the methods used by it, as well as to establish the reasons for the subsequent reforms.

Conclusion. The basis for the unification of party and Soviet state control was the analysis of the provincial experience of the RKI in 1920-1922. A significant obstacle to the broader development of both organizational and auditing activities of the Kursk Provincial Branch of the Russian Academy of Sciences in the period under study was the insufficient number and low level of their training.
Constitutional legal limits to privacy protection
Authors: Kamenskii M. A.
Published: July 2024

Relevance. The right to privacy, as one of the basic constitutional rights of man and citizen, is subject to protection in accordance with Art. 23, 24 of the Constitution of the Russian Federation. On the basis of constitutional justice and the scientific views of theorists, the content of the law in question is disclosed, problems of a legislative and terminological nature that affect its content and the establishment of limits of constitutional legal protection are described.

The purpose of the study is to supplement theoretical provisions that contribute to the deepening of scientific knowledge about the protection of the constitutional right to privacy, its content and the limits of constitutional legal protection.

Objectives: to analyze the practice of the Constitutional and Supreme Court of the Russian Federation in cases of protecting the right to privacy and the scientific positions of scientists regarding its concept; describe the state of constitutional and legal protection and the content of the right in question; identify legislative and terminological gaps impeding its proper protection; define the boundaries of constitutional legal protection.

Methodology. The study was carried out using methods of analysis and synthesis, induction and deduction, documentary, formal-legal, system-analytical and formal-logical methods. The results of the study are formulated theoretical provisions characterizing the content of the right to privacy and the objective limits of its constitutional and legal protection.

Conclusion. In the theory of constitutional law and the practice of the Constitutional Court of the Russian Federation, there is a change in the trend in the interpretation of the right to privacy from «negative» to «positive». It is transformed by supplementing the concept of private life with new types of information that make it up (the right to genetic inviolability, inviolability of personal data, secrecy when using reproductive technologies, etc.). A forecast is given on the modernization of the system of personal human rights with the recognition of an independent right to protect personal data.
The right to protect the image of a minor: methods of implementation and specifics of protection
Authors: Grigorieva I. M.
Published: July 2024

Relevance. The article analyzes the problems of protecting the image of minors in accordance with Art. 152.1 of the Civil Code of the Russian Federation, including judicial methods of its protection. The inconsistency of judicial practice on the application of provisions on the protection of the right to inviolability of the image of children is noted. An assessment of the norm under consideration in the context of law enforcement is given and legislative solutions are proposed to eliminate the shortcomings of its revision.

The purpose of the study is to supplement and develop theoretical provisions that contribute to the deepening of scientific knowledge on the protection of the right to image children and the uniform application of Art. 152.1 of the Civil Code of the Russian Federation.

Objectives: to analyze the decisions and decisions of the Supreme Court of the Russian Federation, courts of general jurisdiction in cases of protecting the right to image a minor; identify the reasons for the inconsistency of court decisions that impede the proper protection of this right; clarify the existing gaps in the version of Art. 152.1 of the Civil Code of the Russian Federation; formulate proposals aimed at improving the protection of photographs and video images of minors.

Methodology. When writing the article, the author used methods of analysis and synthesis, induction and deduction, as well as dialectical-materialistic, formal-legal, formal-logical, system-analytical, documentary methods, as well as a method for generalizing judicial practice. The results of the study are applied and are reflected in the findings and formulated proposals for solving theoretical and practical problems related to the protection of the image of minors.

Conclusion. The norm on the protection of the right to image requires modernization in terms of eliminating gaps that require the attention of the legislator. To overcome the contradictory interpretation of its meaning and the disunity of judicial practice, it is necessary to consolidate the concept of consent as a bilateral civil law transaction, introduce property compensation, and determine the rights of the second parent in case of his disagreement with the use of the child's image.
Usability Assessment Methods for Mobile Apps for Physical Rehabilitation: Umbrella Review
Authors: Hach Sylvia , Alder Gemma , Stavric Verna , Taylor Denise , Signal Nada
Published: July 2024

Background

Usability has been touted as one determiner of success of mobile health (mHealth) interventions. Multiple systematic reviews of usability assessment approaches for different mHealth solutions for physical rehabilitation are available. However, there is a lack of synthesis in this portion of the literature, which results in clinicians and developers devoting a significant amount of time and effort in analyzing and summarizing a large body of systematic reviews.

Objective

This study aims to summarize systematic reviews examining usability assessment instruments, or measurements tools, in mHealth interventions including physical rehabilitation.

Methods

An umbrella review was conducted according to a published registered protocol. A topic-based search of PubMed, Cochrane, IEEE Xplore, Epistemonikos, Web of Science, and CINAHL Complete was conducted from January 2015 to April 2023 for systematic reviews investigating usability assessment instruments in mHealth interventions including physical exercise rehabilitation. Eligibility screening included date, language, participant, and article type. Data extraction and assessment of the methodological quality (AMSTAR 2 [A Measurement Tool to Assess Systematic Reviews 2]) was completed and tabulated for synthesis.

Results

A total of 12 systematic reviews were included, of which 3 (25%) did not refer to any theoretical usability framework and the remaining (n=9, 75%) most commonly referenced the ISO framework. The sample referenced a total of 32 usability assessment instruments and 66 custom-made, as well as hybrid, instruments. Information on psychometric properties was included for 9 (28%) instruments with satisfactory internal consistency and structural validity. A lack of reliability, responsiveness, and cross-cultural validity data was found. The methodological quality of the systematic reviews was limited, with 8 (67%) studies displaying 2 or more critical weaknesses.

Conclusions

There is significant diversity in the usability assessment of mHealth for rehabilitation, and a link to theoretical models is often lacking. There is widespread use of custom-made instruments, and preexisting instruments often do not display sufficient psychometric strength. As a result, existing mHealth usability evaluations are difficult to compare. It is proposed that multimethod usability assessment is used and that, in the selection of usability assessment instruments, there is a focus on explicit reference to their theoretical underpinning and acceptable psychometric properties. This could be facilitated by a closer collaboration between researchers, developers, and clinicians throughout the phases of mHealth tool development.

Trial Registration

PROSPERO CRD42022338785; https://www.crd.york.ac.uk/prospero/#recordDetails
National and Regional Trends in the Prevalence of Hypertension in South Korea Amid the Pandemic, 2009-2022: Nationwide Study of Over 3 Million Individuals
Authors: Lee Hyeri , Kim Minji , Woo Selin , Park Jaeyu , Kim Hyeon Jin , Kwon Rosie , Koyanagi Ai , Smith Lee , Kim Min Seo , López Sánchez Guillermo F , Dragioti Elena , Lee Jinseok , Lee Hayeon , Rahmati Masoud , Rhee Sang Youl , Lee Jun Hyuk , Woo Ho Geol , Yon Dong Keon
Published: July 2024

Background

Understanding the association between hypertension prevalence and socioeconomic and behavioral variables during a pandemic is essential, and this analysis should extend beyond short-term trends.

Objective

This study aims to examine long-term trends in the prevalence of participants diagnosed with and receiving treatment for hypertension, using data collected by a nationally representative survey from 2009 to 2022, which includes the COVID-19 pandemic era.

Methods

A nationwide, population-based, cross-sectional study used data collected from the South Korea Community Health Survey between 2009 and 2022. The study sample comprised 3,208,710 Korean adults over a period of 14 years. We aimed to assess trends in the prevalence of participants diagnosed with and receiving treatment for hypertension in the national population from 2009 to 2022, with a specific focus on the COVID-19 pandemic, using weighted linear regression models.

Results

Among the included 3,072,546 Korean adults, 794,239 (25.85%) were aged 19-39 years, 1,179,388 (38.38%) were aged 40-59 years; 948,097 (30.86%) were aged 60-79 years, and 150,822 (4.91%) were aged 80 years or older. A total of 1,426,379 (46.42%) were men; 761,896 (24.80%) and 712,264 (23.18%) were diagnosed with and received treatment for hypertension, respectively. Although the overall prevalence over the 14-year period increased, the upward trends of patients diagnosed with and receiving treatment for hypertension decreased during the COVID-19 pandemic era compared with the prepandemic era (β difference for trend during vs before the pandemic –.101, 95% CI –0.107 to –0.094 vs –.133, 95% CI –0.140 to –0.127). Notably, the trends in prevalence during the pandemic were less pronounced in subgroups of older adults (≥60 years old) and individuals with higher alcohol consumption (≥5 days/month).

Conclusions

This nationwide representative study found that the national prevalence of participants diagnosed with and receiving treatment for hypertension increased during the prepandemic era. However, there was a marked decrease in these trends during the prepandemic era, compared with the pandemic era, particularly among specific subgroups at increased risk of negative outcomes. Future studies are needed to evaluate the factors associated with changes in the prevalence of hypertension during the COVID-19 pandemic.
National and Regional Trends in the Prevalence of Hypertension in South Korea Amid the Pandemic, 2009-2022: Nationwide Study of Over 3 Million Individuals (Preprint)
Authors: Lee Hyeri , Kim Minji , Woo Selin , Park Jaeyu , Kim Hyeon Jin , Kwon Rosie , Koyanagi Ai , Smith Lee , Kim Min Seo , López Sánchez Guillermo F , Dragioti Elena , Lee Jinseok , Lee Hayeon , Rahmati Masoud , Rhee Sang Youl , Lee Jun Hyuk , Woo Ho Geol , Yon Dong Keon
Published: July 2024

BACKGROUND

Understanding the association between hypertension prevalence and socioeconomic and behavioral variables during a pandemic is essential, and this analysis should extend beyond short-term trends.

OBJECTIVE

This study aims to examine long-term trends in the prevalence of participants diagnosed with and receiving treatment for hypertension, using data collected by a nationally representative survey from 2009 to 2022, which includes the COVID-19 pandemic era.

METHODS

A nationwide, population-based, cross-sectional study used data collected from the South Korea Community Health Survey between 2009 and 2022. The study sample comprised 3,208,710 Korean adults over a period of 14 years. We aimed to assess trends in the prevalence of participants diagnosed with and receiving treatment for hypertension in the national population from 2009 to 2022, with a specific focus on the COVID-19 pandemic, using weighted linear regression models.

RESULTS

Among the included 3,072,546 Korean adults, 794,239 (25.85%) were aged 19-39 years, 1,179,388 (38.38%) were aged 40-59 years; 948,097 (30.86%) were aged 60-79 years, and 150,822 (4.91%) were aged 80 years or older. A total of 1,426,379 (46.42%) were men; 761,896 (24.80%) and 712,264 (23.18%) were diagnosed with and received treatment for hypertension, respectively. Although the overall prevalence over the 14-year period increased, the upward trends of patients diagnosed with and receiving treatment for hypertension decreased during the COVID-19 pandemic era compared with the prepandemic era (β difference for trend during vs before the pandemic –.101, 95% CI –0.107 to –0.094 vs –.133, 95% CI –0.140 to –0.127). Notably, the trends in prevalence during the pandemic were less pronounced in subgroups of older adults (≥60 years old) and individuals with higher alcohol consumption (≥5 days/month).

CONCLUSIONS

This nationwide representative study found that the national prevalence of participants diagnosed with and receiving treatment for hypertension increased during the prepandemic era. However, there was a marked decrease in these trends during the prepandemic era, compared with the pandemic era, particularly among specific subgroups at increased risk of negative outcomes. Future studies are needed to evaluate the factors associated with changes in the prevalence of hypertension during the COVID-19 pandemic.
Breaking Down the Lockdown: The Impact of Stay-At-Home Mandates on Uncertainty and Sentiments (Preprint)
Authors: Biliotti Carolina , Bargagli-Stoffi Falco J. , Fraccaroli Nicolò , Puliga Michelangelo , Riccaboni Massimo
Published: July 2024

BACKGROUND

Since the spread of the SARS-CoV-2 virus and the lockdown measures went hand-in-hand, it is difficult to distinguish how public opinion reacted to the lockdown measures from the reactions to COVID-19.

OBJECTIVE

We analyze the causal effect of COVID-19 lockdown policies on sentiment and uncertainty using the Italian lockdown in February 2020 as a quasi-experiment. Communities inside and just outside the lockdown area were equally confronted with COVID-19 at the time of the implementation of the policy, offering a form of random allocation of the lockdown. The two areas had also balanced socioeconomic and demographic characteristics before the lockdown, indicating that the definition of the boundaries of the area under strict lockdown approximates a randomized experiment. This allows to identify the causal impact of lockdowns on public emotions, disentangling the changed due to the policy itself, from the changes induced by the spread of the novel virus.

METHODS

We employ Twitter data, natural language models (N = 24,261), and a difference-in-differences approach to compare sentiment changes within (n=1,567) and outside (n=22,694) the lockdown areas before and after the beginning of the lockdown. Tweets are classified into four categories—economics, health, politics, and lockdown policy—to analyze the corresponding emotional responses.

RESULTS

We find that the lockdown had no significant effect on economic uncertainty (b=0.005, SE=0.007, t(125)=0.70, P =.48) or economic negative sentiment (b=-0.011, SE=0.0089, t(125)=-1.32, P =.19), but increased uncertainty about health (b=0.036, SE=0.0065, t(125)=5.55, P<.001) and the lockdown policy (b=0.026, SE=0.006, t(125)=4.47, P<.001) and negative sentiment towards politics (b=0.025, SE=0.011, t(125)=2.33, P =.02), suggesting that lockdowns have wide externalities beyond health.

CONCLUSIONS

Our results emphasize the need for authorities to use these findings to improve future policies and communication efforts to mitigate uncertainty and social panic.
mujeres del guetto también las pueden”.
Authors: Ángeles Villanueva Alain
Published: July 2024

Este artículo continúa con la trayectoria y dimensiones identitarias de las raperas en Morelia, Michoacán, México, ahora con gran parte de las que surgieron en la segunda década del presente siglo. Contiene un breve contexto de la comunidad rapera de Morelia en dicha época; seguido de las mujeres que rimaron por una corta temporada y el caso de quienes se encuentran vigentes. Esta interpretación se realizó mediante comunicación personal con las protagonistas, historias de vida focales y el análisis de sus expresiones identitarias en el discurso oral de sus canciones.
Metodologias ativas em sala de aula de Ciências: um relato da regência na Residência Pedagógica Interdisciplinar Biologia
Authors: Sousa Tayanara , De Souza Amélia Fernandes de Souza , Do Nascimento Silva Silvana
Published: July 2024

Metodologias tradicionais de ensino e a sua utilização são questionados, principalmente por pessoas cada vez mais conectadas e tecnológicas. Nessa direção, as metodologias ativas de aprendizagem ganham força por serem consideradas uma ferramenta complementar aos processos de ensino e aprendizagem. Este relato de experiência busca refletir sobre três jogos utilizados em uma escola da rede estadual de ensino, na cidade de Jequié-BA. Como elementos de Metodologias Ativas de Aprendizagem, utilizou-se o Quiz online, jogo da memória e cartilhas sobre assuntos de Ciências. Para isso, foi realizada uma revisão sistemática da literatura à procura de outros relatos de experiência, como forma de apresentar as principais contribuições do método para o processo de ensino e aprendizagem, buscando auxiliar na elaboração das aulas de Ciências no contexto do Núcleo Interdisciplinar Biologia da Residência Pedagógica. Se tratando das metodologias utilizadas, obtivemos os seguintes resultados: as atividades práticas foram concluídas com êxito, tornando-se notável que as metodologias ativas se mostraram inovadoras, afinal, colocam os estudantes como os principais agentes de seu aprendizado, fazendo com que se torne viável existirem estímulos que são incentivados pelo docente, proporcionando ao discente um aprendizado de maneira mais participativa.
Cemento osseous dysplasia(COD) of the mandibular teeth misdiagnosed as periapical lesion; cone beam CT-based case report
Authors: Han Won-Jeong
Published: July 2024

Cemento osseous dysplasia (COD) is a lesion that occurs in the periapical and tooth-bearing area where normal bone tissue is replaced by fibrous tissue and metaplastic bone. The cause is not clearly known. COD is often discovered incidentally without any symptoms. It is more common in females and mandibular molars. The involved tooth is vital. In radiological imaging, the lesion has a well defined border. The internal density of the lesion depends on the maturity of the lesion. Radiolucent and mixed lesions of COD are sometimes mistaken for periapical lesions and root canal treatment is performed. Because COD has limited growth, no special treatment is required. Accordingly, The author reports cases of COD in mandibular teeth region referred from other clinics for accurate diagnosis or removal of the lesions and presents the cone beam computed tomography images of the cases to help clinicians make an accurate diagnosis.
Pharmacological Management of Hypertension: New Drugs and Mechanisms
Authors: R Selvin
Published: July 2024

Hypertension remains a leading global health challenge, contributing significantly to morbidity and mortality due to cardiovascular diseases. Traditional antihypertensive therapies, while effective for many, often fall short in certain populations, necessitating the development of novel pharmacological agents. This review explores recent advancements in the pharmacological management of hypertension, focusing on new drug classes and their mechanisms of action. We discuss innovations such as angiotensin receptor-neprilysin inhibitors (ARNIs), endothelin receptor antagonists, and sodium-glucose co-transporter 2 (SGLT2) inhibitors, highlighting their clinical efficacy and safety profiles. Additionally, we examine emerging mechanisms targeted by these drugs, including modulation of the renin-angiotensin-aldosterone system (RAAS), endothelial function enhancement, and metabolic pathway alteration. The review also addresses the potential for personalized medicine approaches in optimizing hypertension management. By elucidating these advancements, we aim to provide a comprehensive understanding of the future directions in hypertensive therapy, paving the way for improved patient outcomes through more precise and effective treatment strategies.
A ARBITRAGEM COMO CONTRAPONTO À MOROSIDADE JUDICIAL NA RESOLUÇÃO DOS CONFLITOS DA ADMINISTRAÇÃO PÚBLICA
Authors: Batista Larissa Pereira , Luz Rodrigo Barbosa , Gomes Luiz de Souza , Mota Raquel Cistrina Lucas , Santos Ciro Meneses
Published: July 2024

A morosidade no sistema judiciário brasileiro é uma questão que, continuamente, vem sendo debatida tanto no campo dos estudos sobre o Estado. Essa lentidão judicial na resolução das demandas resulta em insatisfação por parte dos cidadãos e prejudica a percepção da eficácia da justiça.Visando conferir mais eficiência em sua área de atuação o Poder Judiciário tem, cada vez mais, aderido à mecanismos de gestão. Entre estes, encontram-se as formas consensuais de resolução de conflitos, das quais fazem parte a mediação, a conciliação e a arbitragem. A Arbitragem, por sua vez, é considerada como um importante instrumento para pacificação de controvérsias, como meio alternativo à morosidade dosistema judiciário brasileiro. Este trabalho tem por objetivo destacaros possíveis benefícios que a arbitragem pode trazer para a resolução dos conflitos na Administração Pública. Para tal, foi realizada uma pesquisa bibliográfica de abordagem qualitativa e natureza aplicada, através levantamento de dados indiretos, mediante revisão bibliográfica. Como resultado do presente estudo, foi possível observar que a utilização do instituto da Arbitragem confere mais eficiência e celeridadenas demandas que envolvem a Administração Pública pela agilidade na resolução dos problemas.