bluuebunny/crossref_metadata_2025 huggingface dataset:
No Association Between Suicidality and Weight Among School-Attending Adolescents in the United Arab Emirates
Authors: Ibrahim Hania , Mahfoud Ziyad R.
Published: March 2021

Previous data on the link between weight and suicidality is heterogenous. We aim to investigate the potential association between weight and suicidality among adolescents in the United Arab Emirates (UAE). We hypothesize that an association exists between weight and suicidality, with those at both extremes of weight suffering higher rates of suicidal ideation, planning and attempts. The 2016 UAE Global School Health Survey (GSHS) was used. Weight categories based on the World Health Organization Body Mass Index charts were generated. Suicidality measures were based on questions on suicide ideation, planning, and attempt. Univariate and multivariate binary logistic regression were used. Overall, 3.6, 21.4, and 17.5% of students were found to be underweight, overweight, and obese, respectively. In total, 492 students (14.6%) reported suicidal ideation, 397 (11.8%) reported planning, and 389 (11.4%) reported attempts within the twelve months prior to the survey. In the multivariate logistic regression, being female, older, and of lower socioeconomic status were significantly associated with increased suicidal ideation, planning and attempts. Increased parental involvement was associated with decreased suicidality. The association between weight category and suicidality did not reach statistical significance. A significant proportion of Emirati teens are under- or over-weight, with one in seven and one in nine having considered or attempted suicide, respectively. However, this study finds no significant association between weight and suicide ideation, planning, or attempts. This may be due to cultural differences in weight perception. Further research into this association can aid in tailoring suicide prevention interventions.
Meaning-Centered Coping in the Era of COVID-19: Direct and Moderating Effects on Depression, Anxiety, and Stress
Authors: Eisenbeck Nikolett , Carreno David F. , Pérez-Escobar José Antonio
Published: March 2021

The COVID-19 pandemic has subjected most of the world’s population to unprecedented situations, like national lockdowns, health hazards, social isolation and economic harm. Such a scenario calls for urgent measures not only to palliate it but also, to better cope with it. According to existential positive psychology, well-being does not simply represent a lack of stress and negative emotions but highlights their importance by incorporating an adaptive relationship with them. Thus, suffering can be mitigated (and transformed into growth) by, among other factors, adopting an attitude of positive reframing, maintaining hope, existential courage, life appreciation, engagement in meaningful activities, and prosociality. The conglomerate of these elements has been recently denominated as meaning-centered coping. In this study, we evaluated the protective role of this type of coping on mental health. A sample of 12,243 participants from 30 countries across all continents completed measures of Meaning-Centered Coping Scale (MCCS), depression, stress, anxiety and stressful COVID-19 related conditions they experienced. Results indicated that meaning-centered coping was strongly associated with diminished symptoms of stress, anxiety, and depression. Moreover, it moderated various relationships between vulnerability factors and markers of psychological distress, especially in the case of depression. These findings call for attention to meaning-centered coping approaches in the context of hardship, such as the current COVID-19 health crisis. In these difficult times, decision-makers and health organizations may integrate these approaches into their guidelines.
Gaze Coordination of Groups in Dynamic Events – A Tool to Facilitate Analyses of Simultaneous Gazes Within a Team
Authors: Fasold Frowin , Nicklas André , Seifriz Florian , Schul Karsten , Noël Benjamin , Aschendorf Paula , Klatt Stefanie
Published: March 2021

The performance and the success of a group working as a team on a common goal depends on the individuals’ skills and the collective coordination of their abilities. On a perceptual level, individual gaze behavior is reasonably well investigated. However, the coordination of visual skills in a team has been investigated only in laboratory studies and the practical examination and knowledge transfer to field studies or the applicability in real-life situations have so far been neglected. This is mainly due to the fact that a methodological approach along with a suitable evaluation procedure to analyze the gaze coordination within a team in highly dynamic events outside the lab, is still missing. Thus, this study was conducted to develop a tool to investigate the coordinated gaze behavior within a team of three human beings acting with a common goal in a dynamic real-world scenario. This team was a (three-person) basketball referee team adjudicating a game. Using mobile eye-tracking devices and an indigenously designed software tool for the simultaneous analysis of the gaze data of three participants, allowed, for the first time, the simultaneous investigation of the coordinated gaze behavior of three people in a highly dynamic setting. Overall, the study provides a new and innovative method to investigate the coordinated gaze behavior of a three-person team in specific tasks. This method is also applicable to investigate research questions about teams in dynamic real-world scenarios and get a deeper look at interactions and behavior patterns of human beings in group settings (for example, in team sports).
Effects of Mental Fatigue in Total Running Distance and Tactical Behavior During Small-Sided Games: A Systematic Review With a Meta-Analysis in Youth and Young Adult's Soccer Players
Authors: Clemente Filipe Manuel , Ramirez-Campillo Rodrigo , Castillo Daniel , Raya-González Javier , Silva Ana Filipa , Afonso José , Sarmento Hugo , Rosemann Thomas , Knechtle Beat
Published: March 2021

Background: Mental fatigue can impact physical demands and tactical behavior in sport-related contexts. Small-sided games (SSGs) are often used to develop a specific sport-related context. However, the effects of mental fatigue on physical demands and tactical behaviors during soccer SSGs have not been aggregated for systematical assessment.

Objective: This systematic review (with a meta-analysis) was conducted to compare the effects of mental fatigue vs. control conditions in terms of the total running distance and tactical behavior of soccer players during SSGs.

Methods: The data sources utilized were PubMed, PsycINFO, Scielo, Scopus, SPORTDiscus, and Web of Science. The study eligibility criteria were established based on PICOS: (i) Population: healthy youth and young adult men soccer players with regular training practice and belonging to teams with regular competitions; (ii) Intervention: exposed to mental fatigue-induced protocols only before SSGs; (iii) Comparator: control conditions (passive or active not promoting mental fatigue) before SSGs; (iv) Outcomes: physical demands (total running distance) and tactical behavior (attacking behavior accuracy, pass decision-making accuracy, and space exploration index); (v) Study design: counterbalanced cross-over design; and (vi) only full-text and original articles written in English.

Results: The database search initially identified 111 titles. From those, six articles were eligible for the systematic review and meta-analysis. Results showed no significant effect of fatigue on total running distance (ES = 0.13; p = 0.307) and tactical behavior (ES = 0.56; p = 0.079).

Conclusions: A non-significant effect of mental fatigue on total running distance and tactical behaviors performed by soccer players during SSGs was found in this systematic review.
Field Test of a Passive Infrared Camera for Measuring Trail-Based Physical Activity
Authors: Abildso Christiaan G. , Haas Vaike , Daily Shay M. , Bias Thomas K.
Published: March 2021

Introduction: Trails are ubiquitous and far-reaching, but research on the impact trails have on physical activity is limited by the lack of resource-efficient, accurate, and practical systematic observation tools. Commonly used infrared trail sensors count trail use and may broadly differentiate activity (i.e., bicyclist vs. pedestrian), but cannot detect nuances needed for outcomes research such as frequency, intensity, time, and type of activity. Motion-activated passive infrared cameras (PICs), used in ecological research and visitor management in wildlife areas, have potential applicability as a systematic observation data collection tool.

Materials and Methods: We conducted a 7-month field test of a PIC as a systematic observation data collection tool on a hiking trail, using photos to identify each trail user's physical activity type, age, sex, and other characteristics. We also tallied hourly trail use counts from the photos, using Bland–Altman plots, paired t-tests, Concordance Correlation Coefficient, Kendall's Tau-b, and a novel inter-counter reliability measure to test concordance against concurrent hourly counts from an infrared sensor.

Results: The field test proved informative, providing photos of 2,447 human users of the trail over 4,974 h of data collection. Nearly all of the users were walkers (94.0%) and most were male (69.2%). More of the males used the trail alone (44.8%) than did females (29.8%). Concordance was strong between instruments (p < 0.01), though biased (p < 0.01). Inter-counter reliability was 91.1% during the field study, but only 36.2% when excluding the hours with no detectable trail use on either device. Bland–Altman plots highlighted the tendency for the infrared sensor to provide higher counts, especially for the subsample of hours that had counts >0 on either device (14.0%; 694 h).

Discussion: The study's findings highlight the benefits of using PICs to track trail user characteristics despite the needs to further refine best practices for image coding, camera location, and settings. More widespread field use is limited by the extensive amount of time required to code photos and the need to validate the PICs as a trail use counter. The future potential of PICs as a trail-specific PA research and management tool is discussed.
UAV Formation Shape Control via Decentralized Markov Decision Processes
Authors: Azam Md Ali , Mittelmann Hans D. , Ragi Shankarachary
Published: March 2021

In this paper, we present a decentralized unmanned aerial vehicle (UAV) swarm formation control approach based on a decision theoretic approach. Specifically, we pose the UAV swarm motion control problem as a decentralized Markov decision process (Dec-MDP). Here, the goal is to drive the UAV swarm from an initial geographical region to another geographical region where the swarm must form a three-dimensional shape (e.g., surface of a sphere). As most decision-theoretic formulations suffer from the curse of dimensionality, we adapt an existing fast approximate dynamic programming method called nominal belief-state optimization (NBO) to approximately solve the formation control problem. We perform numerical studies in MATLAB to validate the performance of the above control algorithms.
Feeding Behaviour and Bioavailability of Essential Amino Acids in Shrimp Penaeus monodon Fed Fresh and Leached Fishmeal and Fishmeal-Free Diets
Authors: Simon Cedric J. , Truong Ha , Habilay Natalie , Hines Barney
Published: March 2021

The complete replacement of fishmeal with terrestrial meals did not have a negative impact on the attractiveness, palatability, and apparent digestibility of the formulation. Shrimp were found on average to eat more and have similar appetite revival on the terrestrial meal-based formulation (TM) diet compared to the traditional fishmeal-based formulation (FM) diet. However, methionine (Met) and lysine (Lys) leached out rapidly from the TM diet, and as a result, this initially overfortified diet showed lower levels of those AA in comparison to FM after 60 min immersion. Both dietary Lys and Met were sub-optimal in TM within 120 min of immersion, whereas in comparison, the FM diet supplied consistent levels of EAA for up to 240 min immersion. Nonetheless, shrimp fed fresh TM had significantly higher peak haemolymph concentrations at 30 and 60 min for total AA, Met, and Lys than FM-fed shrimp. The over-supply of CAA far compensated leaching losses, and CAA were well absorbed and used by the shrimp within 120 min, with no obvious signs of asynchronous absorption of CAA to protein-bound AA. However, shrimp fed the TM diet that had leached out for 60 min, had haemolymph concentrations of Met and Lys that were only 41% and 44% of the ones on fresh feed respectively, while there was a negligible effect of leaching on FM. This study provides further insight into the feeding behaviour and bioavailability of dietary amino acids for P. monodon juveniles.
Effects on Synchronization and Reproductive Efficiency of Delaying the Removal of the Intravaginal Progesterone Device by 24 h in the 5d Co-Synch Protocol in Heifers
Authors: Fernandez-Novo Aitor , Santos-Lopez Sergio , Pesantez-Pacheco Jose Luis , Pérez-Villalobos Natividad , Heras-Molina Ana , Gonzalez-Martin Juan Vicente , Astiz Susana
Published: March 2021

In beef herds, increasing animal welfare, improving reproductive performance and easing animal management are key goals in farm economics. We explored whether delaying the removal of the intravaginal progesterone device by 24 h in heifers synchronized with a 5d Co-synch 72-h protocol could improve reproductive efficiency of fixed-time artificial insemination (FTAI). In experiment 1, we examined the total synchronization rate (TSR) in cycling Holstein heifers. Heifers (13.4 ± 0.69 mo.) were randomly assigned to the standard 5d Co-synch 56-h protocol (5dCo56; n = 10), 5d Co-synch 72-h (5dCo72; n = 17), or the modified 5d Co-synch 72-h protocol, in which removal of the progesterone device was delayed by 24 h (6dCo48; n = 19). In experiment 2, 309 cycling beef heifers on 18 commercial farms were subjected to the 5d Co-synch 72-h or 6-d Co-synch 48-h protocol and conception rate (CR) studied. In experiment 1, the three protocols led no differences on TSRs of 80.0% (5dCo56), 88.2% (5dCo72), and 89.5% (6dCo48). In experiment 2, the CR from the beef heifers, observed during two consecutive reproductive seasons did not differ: 59.7% for 5dCo72 and 62.0% for 6dCo48 (p = 0.907). Therefore, delaying removal by 24 h provides satisfactory results without reducing reproductive efficiency of heifers.
Evaluation of Antibiotic Dissemination into the Environment and Untreated Animals, by Analysis of Oxytetracycline in Poultry Droppings and Litter
Authors: Pokrant Ekaterina , Yévenes Karina , Trincado Lina , Terraza Gigliola , Galarce Nicolás , Maddaleno Aldo , Martín Betty San , Lapierre Lisette , Cornejo Javiera
Published: March 2021

Oxytetracycline (OTC) is widely used in broiler chickens. During and after treatment a fraction of OTC is excreted in its original form and as its epimer, 4-epi-OTC in droppings. To address the transfer of OTC into the environment, we evaluated the dissemination of OTC and 4-epi-OTC from treated birds to the environment and sentinels, through the simultaneous analysis of broiler droppings and litter. Male broiler chickens were bred in controlled conditions. One group was treated by orogastric tube with 80 mg kg−1 of OTC and two groups received no treatment (sentinels). OTC+4-epi-OTC were analyzed and detected by a HPLC-MS/MS post the end of treatment. The highest concentrations of OTC+4-epi-OTC were detected in the droppings of treated birds 14-days following the end of treatment (2244.66 µg kg−1), and one day following the end of treatment in the litter (22,741.68 µg kg−1). Traces of OTC+4-epi-OTC were detected in the sentinels’ droppings and litter (<12.2 µg kg−1). OTC+4-epi-OTC can be transferred from treated birds to the environment and to other untreated birds. The presence and persistence of OTC+4-epi-OTC in litter could contribute to the selection of resistant bacteria in the environment, increasing the potential hazard to public and animal health.
Enhancing Robustness of Per-Packet Load-Balancing for Fat-Tree
Authors: Lim Chansook
Published: March 2021

Fat-tree networks have many equal-cost redundant paths between two hosts. To achieve low flow completion time and high network utilization in fat-tree, there have been many efforts to exploit topological symmetry. For example, packet scatter schemes, which spray packets across all equal-cost paths relying on topological symmetry, work well when there is no failure in networks. However, when symmetry of a network is disturbed due to a network failure, packet scatter schemes may suffer massive packet reordering. In this paper, we propose a new load balancing scheme named LBSP (Load Balancing based on Symmetric Path groups) for fat-trees. LBSP partitions equal-cost paths into equal sized path groups and assigns a path group to each flow so that packets of a flow are forwarded across paths within the selected path group. When a link failure occurs, the flows affected by the failure are assigned an alternative path group which does not contain the failed link. Consequently, packets in one flow can still experience almost the same queueing delay. Simulation results show that LBSP is more robust to network failures compared to the original packet scatter scheme. We also suggest a solution to the queue length differentials between path groups.
Continuous-Time Fast Motion of Explosion Fragments Estimated by Bundle Adjustment and Spline Representation Using HFR Cameras
Authors: Ni Yubo , Liu Feng , Wu Yi , Wang Xiangjun
Published: March 2021

This paper introduces a continuous-time fast motion estimation framework using high frame-rate cameras. To recover the high-speed motions trajectory, we inherent the bundle adjustment using a different frame-rate strategy. Based on the optimized trajectory, a cubic B-spline representation was proposed to parameter the continuous-time position, velocity and acceleration during this fast motion. We designed a high-speed visual system consisting of the high frame-rate cameras and infrared cameras, which can capture the fast scattered motion of explosion fragments and evaluate our method. The experiments show that bundle adjustment can greatly improve the accuracy and stability of the trajectory estimation, and the B-spline representation of the high frame-rate can estimate the velocity, acceleration, momentum and force of each fragments at any given time during its motion. The related estimated result can achieve under 1% error.
Optimization of Laser Fired Contact Process for the Formation of an Al-BSF Layer
Authors: Park Jeong Eun , Choi Won Seok , Lim Donggun
Published: March 2021

The back-surface field (BSF) layer obtained through the laser fired contact (LFC) process is the key to increasing the efficiency of solar cells. In this paper, we studied the optimization of LFC process parameters—focusing on laser frequency, influence, and speed—to achieve good ohmic contacts, and to reduce the heat-affected zone (HAZ). As frequency increases, interactions between the laser and particles increase, with the particles becoming overly heated. This generates the thermal effect, in which heat is transferred to particles not directly affected by the laser—resulting in the HAZ becoming wider and deeper. Under different laser power conditions, depths of approximately 18 and 8.3 μm were observed at laser speeds of 10 and 100 mm/s, respectively. This analysis of performance variables allowed us to identify those best suited to forming an Al-BSF layer approximately 1.2 μm thick, which resulted in the best LFC procedure while minimizing the HAZ area. HAZ size was minimized at a frequency of 400 kHz, using 5 W laser power, and a laser speed of 100 mm/s, while the best cell characteristics were obtained using a laser pitch of 500 μm and a single laser process.
Validation of WRF-Chem Model and CAMS Performance in Estimating Near-Surface Atmospheric CO2 Mixing Ratio in the Area of Saint Petersburg (Russia)
Authors: Nerobelov Georgy , Timofeyev Yuri , Smyshlyaev Sergei , Foka Stefani , Mammarella Ivan , Virolainen Yana
Published: March 2021

Nowadays, different approaches for CO2 anthropogenic emission estimation are applied to control agreements on greenhouse gas reduction. Some methods are based on the inverse modelling of emissions using various measurements and the results of numerical chemistry transport models (CTMs). Since the accuracy and precision of CTMs largely determine errors in the approaches for emission estimation, it is crucial to validate the performance of such models through observations. In the current study, the near-surface CO2 mixing ratio simulated by the CTM Weather Research and Forecasting—Chemistry (WRF-Chem) at a high spatial resolution (3 km) using three different sets of CO2 fluxes (anthropogenic + biogenic fluxes, time-varying and constant anthropogenic emissions) and from Copernicus Atmosphere Monitoring Service (CAMS) datasets have been validated using in situ observations near the Saint Petersburg megacity (Russia) in March and April 2019. It was found that CAMS reanalysis data with a low spatial resolution (1.9° × 3.8°) can match the observations better than CAMS analysis data with a high resolution (0.15° × 0.15°). The CAMS analysis significantly overestimates the observed near-surface CO2 mixing ratio in Peterhof in March and April 2019 (by more than 10 ppm). The best match for the CAMS reanalysis and observations was observed in March, when the wind was predominantly opposite to the Saint Petersburg urbanized area. In contrast, the CAMS analysis fits the observed trend of the mixing ratio variation in April better than the reanalysis with the wind directions from the Saint Petersburg urban zone. Generally, the WRF-Chem predicts the observed temporal variations in the near-surface CO2 reasonably well (mean bias ≈ (−0.3) − (−0.9) ppm, RMSD ≈ 8.7 ppm, correlation coefficient ≈ 0.61 ± 0.04). The WRF-Chem data where anthropogenic and biogenic fluxes were used match the observations a bit better than the WRF-Chem data without biogenic fluxes. The diurnal time variation in the anthropogenic emissions influenced the WRF-Chem data insignificantly. However, in general, the data of all three WRF-Chem model runs give almost the same CO2 temporal variation in Peterhof in March and April 2019. This could be related to the late start of the growing season, which influences biogenic CO2 fluxes, inaccuracies in the estimation of the biogenic fluxes, and the simplified time variation pattern of the CO2 anthropogenic emissions.
Spatial Variability of Glaciochemistry along a Transect from Zhongshan Station to LGB69, Antarctica
Authors: Huang Weilong , Yan Ming , Mulvaney Robert , Qian Zuoqin , Liu Leibao , An Chunlei , Xiao Cunde , Zhang Yujia
Published: March 2021

The spatial glaciochemical variability of snow samples collected along a transect from Zhongshan Station to Lambert Glacier Basin 69 (LGB69) in Antarctica was investigated. Sea-salt ion concentrations exponentially decreased with increasing distance from the coast and/or altitude. The observed high sea-salt ion concentrations within 20.6 km of the coast may be related to preferential wet or dry deposition of sea-salt aerosols. Methanesulfonic acid (MSA), non-sea-salt sulfate (nssSO42−), and calcium (Ca2+) concentrations decreased along the transect. The mean MSA/nssSO42− value of the surface snow samples (0.34 ± 0.08) indicates that coastal sea areas are their likely source regions. The non-sea-salt Ca2+ (nssCa2+)/Ca2+ percentages of the surface snow and LGB69 snow pit samples reveal that continental dust is the primary Ca2+ source. The δD and δ18O values decreased from the coast inland. The variation of deuterium excess (d-excess) along the transect was stable and d-excess values in the two snow pit samples were low and similar, which indicates that the moisture source region between Zhongshan Station and LGB69 is a coastal sea area. These results reveal the spatial distribution patterns and sources of ions and stable isotopes, as well as factors that influence the deposition of ions and the composition of stable isotopes, which provide important insight for further studies of ice cores drilled in Antarctic coastal regions.
Exploring EEG Characteristics to Identify Emotional Reactions under Videogame Scenarios
Authors: Martínez-Tejada Laura , Puertas-González Alex , Yoshimura Natsue , Koike Yasuharu
Published: March 2021

In this article we present the study of electroencephalography (EEG) traits for emotion recognition process using a videogame as a stimuli tool, and considering two different kind of information related to emotions: arousal–valence self-assesses answers from participants, and game events that represented positive and negative emotional experiences under the videogame context. We performed a statistical analysis using Spearman’s correlation between the EEG traits and the emotional information. We found that EEG traits had strong correlation with arousal and valence scores; also, common EEG traits with strong correlations, belonged to the theta band of the central channels. Then, we implemented a regression algorithm with feature selection to predict arousal and valence scores using EEG traits. We achieved better result for arousal regression, than for valence regression. EEG traits selected for arousal and valence regression belonged to time domain (standard deviation, complexity, mobility, kurtosis, skewness), and frequency domain (power spectral density—PDS, and differential entropy—DE from theta, alpha, beta, gamma, and all EEG frequency spectrum). Addressing game events, we found that EEG traits related with the theta, alpha and beta band had strong correlations. In addition, distinctive event-related potentials where identified in the presence of both types of game events. Finally, we implemented a classification algorithm to discriminate between positive and negative events using EEG traits to identify emotional information. We obtained good classification performance using only two traits related with frequency domain on the theta band and on the full EEG spectrum.
Diffusion Kurtosis Imaging Fiber Tractography of Major White Matter Tracts in Neurosurgery
Authors: Bopp Miriam , Emde Julia , Carl Barbara , Nimsky Christopher , Saß Benjamin
Published: March 2021

Diffusion tensor imaging (DTI)-based fiber tractography is routinely used in clinical applications to visualize major white matter tracts, such as the corticospinal tract (CST), optic radiation (OR), and arcuate fascicle (AF). Nevertheless, DTI is limited due to its capability of resolving intra-voxel multi-fiber populations. Sophisticated models often require long acquisition times not applicable in clinical practice. Diffusion kurtosis imaging (DKI), as an extension of DTI, combines sophisticated modeling of the diffusion process with short acquisition times but has rarely been investigated in fiber tractography. In this study, DTI- and DKI-based fiber tractography of the CST, OR, and AF was investigated in healthy volunteers and glioma patients. For the CST, significantly larger tract volumes were seen in DKI-based fiber tractography. Similar results were obtained for the OR, except for the right OR in patients. In the case of the AF, results of both models were comparable with DTI-based fiber tractography showing even significantly larger tract volumes in patients. In the case of the CST and OR, DKI-based fiber tractography contributes to advanced visualization under clinical time constraints, whereas for the AF, other models should be considered.
Intracranial Venous Sinus Stenting in Idiopathic Intracranial Hypertension: A Case Report and Review of the Literature
Authors: Ramanathan Dinesh , Travis Zachary D. , Omosor Emmanuel , Wilson Taylor , Sahasrabudhe Nikhil , Sen Anish
Published: March 2021

We describe a case of severe headaches, double vision, and progressive vision loss secondary to a ruptured intracranial cyst (IAC) in a 31-year-old woman with no relevant past medical history. The case is peculiar because drainage of the subdural hygroma led to a minimal improvement in vision with persistent elevated intracranial pressure (ICP). Further exploration revealed transverse sinus stenosis necessitating stenting. Evaluation post-stenting showed marked reduction of ICP and improvement in symptoms. This report underscores the importance of comprehensive work-up and suspicion of multiple underlying etiologies that may be crucial to complete resolution of presenting symptoms in some cases. We provide an overview of the clinical indications and evidence for venous sinus stenting in treating idiopathic intracranial hypertension (IIH).
A Novel Role of Bergamottin in Attenuating Cancer Associated Cachexia by Diverse Molecular Mechanisms
Authors: Jung Young Yun , Ko Jeong-Hyeon , Um Jae-Young , Sethi Gautam , Ahn Kwang Seok
Published: March 2021

Purpose: The potential effects of bergamotiin (BGM) on the suppression of cancer cachexia was evaluated under in vitro and in vivo conditions to investigate its possible inhibitory effects on the muscle and fat loss. Method: The differentiated C2C12 and 3T3L1 cells were treated with BGM after the induction of cancer-cachexia with pancreatic cancer conditioned media (CM). The expression levels of the various molecules involved in the differentiation and loss of muscle and fat (MuRF-1, Atrogin-1, C/EBPα, and PPARγ) were analyzed by Western blot and oil red O staining. For in vivo experiment, MIA PaCa-2 cells were injected into the mice (n = 6), and then BGM (1 mg/kg) was intraperitoneally administered to analyze muscle and adipose tissue by Hematoxylin and Eosin staining and Western blot. Result: BGM displayed a significant effect on the inhibition of muscle and fat catabolism under both in vitro and in vivo conditions. The results of the in vivo experiment revealed a remarkable suppressive effect of BGM on the weight loss in mice. Conclusions: The potential effects of BGM on the inhibition of muscle and fat catabolism in vitro and in vivo were thus confirmed. Based on the results, the impact of BGM on cancer cachexia could be possibly analyzed in the future clinical studies.
Significance of the Overexpression of Substance P and Its Receptor NK-1R in Head and Neck Carcinogenesis: A Systematic Review and Meta-Analysis
Authors: González-Moles Miguel Ángel , Ramos-García Pablo , Esteban Francisco
Published: March 2021

The objective of our study has been, through a systematic review and meta-analysis, to increase the scientific evidence on the implications of SP and its receptor NK-1R in head and neck carcinogenesis. We searched studies published before May-2020 without date and publication language restrictions (PubMed, Embase, Web of Science, Scopus). We evaluated the quality of the studies included (QUIPS tool). We performed heterogeneity, sensitivity, small-study effects, and subgroup analyses. A total 16 studies and 1308 cases met inclusion criteria. Qualitative evaluation demonstrated that not all studies were performed with the same scientific rigor, finding the greatest risk of bias in the study confounding and prognostic factors measurement domains. Quantitative evaluation showed a greater SP/NK-1R overexpression in malignant head and neck lesions compared to benign lesions (p = 0.02), and that expression was observed in malignant salivary gland pathology. Likewise, we found a higher overexpression of NK-1R compared to SP (p = 0.02). In conclusion, the results of this systematic review and meta-analysis show evidence that the upregulation of SP and NK-1R are oncogenic events involved in head and neck carcinogenesis, probably acting in the early stages of malignization. In addition, there is evidence of a greater relevance of the upregulation of the NK-1R receptor compared to SP, which highlights the interest in deepening the development of targeted therapies on the receptor. Future studies assessing the relationships between SP/NK-1R among subjects with head and neck tumors could consider the recommendations given in this systematic review and meta-analysis to improve and standardize future research.
Proteomic Analyses of Fibroblast- and Serum-Derived Exosomes Identify QSOX1 as a Marker for Non-invasive Detection of Colorectal Cancer
Authors: Ganig Nicole , Baenke Franziska , Thepkaysone May-Linn , Lin Kuailu , Rao Venkatesh S. , Wong Fang Cheng , Polster Heike , Schneider Martin , Helm Dominic , Pecqueux Mathieu , Seifert Adrian M. , Seifert Lena , Weitz Jürgen , Rahbari Nuh N. , Kahlert Christoph
Published: March 2021

The treatment of colorectal cancer (CRC) has improved during the last decades, but methods for crucial early diagnosis are yet to be developed. The influence of the tumour microenvironment on liquid biopsies for early cancer diagnostics are gaining growing interest, especially with emphasis on exosomes (EXO), a subgroup of extracellular vesicles (EVs). In this study, we established paired cancer-associated (CAFs) and normal fibroblasts (NF) from 13 CRC patients and investigated activation status-related protein abundance in derived EXOs. Immunohistochemical staining of matched patient tissue was performed and an independent test cohort of CRC patient plasma-derived EXOs was assessed by ELISA. A total of 11 differentially abundant EV proteins were identified between NFs and CAFs. In plasma EXOs, the CAF-EXO enriched protein EDIL3 was elevated, while the NF-EXO enriched protein QSOX1 was diminished compared to whole plasma. Both markers were significantly reduced in patient-matched CRC tissue compared to healthy colon tissue. In an independent test cohort, a significantly reduced protein abundance of QSOX1 was observed in plasma EXOs from CRC patients compared to controls and diagnostic ROC curve analysis revealed an AUC of 0.904. In conclusion, EXO-associated QSOX1 is a promising novel marker for early diagnosis and non-invasive risk stratification in CRC.
The Plasma Membrane Ca2+ Pump PMCA4b Regulates Melanoma Cell Migration through Remodeling of the Actin Cytoskeleton
Authors: Naffa Randa , Padányi Rita , Ignácz Attila , Hegyi Zoltán , Jezsó Bálint , Tóth Sarolta , Varga Karolina , Homolya László , Hegedűs Luca , Schlett Katalin , Enyedi Agnes
Published: March 2021

We demonstrated that the plasma membrane Ca2+ ATPase PMCA4b inhibits migration and metastatic activity of BRAF mutant melanoma cells. Actin dynamics are essential for cells to move, invade and metastasize, therefore, we hypothesized that PMCA4b affected cell migration through remodeling of the actin cytoskeleton. We found that expression of PMCA4b in A375 BRAF mutant melanoma cells induced a profound change in cell shape, cell culture morphology, and displayed a polarized migratory character. Along with these changes the cells became more rounded with increased cell–cell connections, lamellipodia and stress fiber formation. Silencing PMCA4b in MCF-7 breast cancer cells had a similar effect, resulting in a dramatic loss of stress fibers. In addition, the PMCA4b expressing A375 cells maintained front-to-rear Ca2+ concentration gradient with the actin severing protein cofilin localizing to the lamellipodia, and preserved the integrity of the actin cytoskeleton from a destructive Ca2+ overload. We showed that both PMCA4b activity and trafficking were essential for the observed morphology and motility changes. In conclusion, our data suggest that PMCA4b plays a critical role in adopting front-to-rear polarity in a normally spindle-shaped cell type through F-actin rearrangement resulting in a less aggressive melanoma cell phenotype.
How Do Young Women with Cancer Experience Oncofertility Counselling during Cancer Treatment? A Qualitative, Single Centre Study at a Danish Tertiary Hospital
Authors: Bentsen Line , Pappot Helle , Hjerming Maiken , Colmorn Lotte B. , Macklon Kirsten T. , Hanghøj Signe
Published: March 2021

Background: Adolescents and young adults (AYAs) with cancer are at risk of therapy-induced infertility. The importance of initial and specialized fertility counselling to this patient group is undisputed. Despite international guidelines, oncofertility counselling is still inadequate. The purpose of this study was to examine how female AYA cancer patients and survivors experienced initial and specialized oncofertility counselling, and to present their specific suggestions on how to improve the oncofertility counselling. Methods: Twelve individual semi-structured interviews were performed with AYAs aged 20–35 with cancer or who were survivors. Participants were recruited via a youth support centre and social organization for AYAs with cancer. Data was analysed using thematic analysis. Results: Three main themes were found: Support is needed for navigating the fertility information jungle; The doctor’s approach determines the content of the patient consultation; Inadequate and worrying information causes mistrust and frustration. Conclusion: Results indicate a continuing problem regarding insufficient oncofertility counselling to AYAs with cancer. To ensure adequate and uniform information, especially in the initial oncofertility counselling, national guidelines for oncology specialists are suggested including multidisciplinary effort and collaboration between oncology and fertility specialists in mind. In addition, participants suggest focus on communication skills.
Combining mTOR Inhibitors and T Cell-Based Immunotherapies in Cancer Treatment
Authors: el Hage Alexandre , Dormond Olivier
Published: March 2021

mTOR regulates several processes that control tumor development, including cancer cell growth, angiogenesis and the immune response to tumor. Accordingly, mTOR inhibitors have been thoroughly explored in cancer therapy but have failed to provide long-lasting anticancer benefits. Several resistance mechanisms that counteract the antitumor effect of mTOR inhibitors have been identified and have highlighted the need to use mTOR inhibitors in combination therapies. In this context, emerging evidence has demonstrated that mTOR inhibitors, despite their immunosuppressive properties, provide anticancer benefits to immunotherapies. In fact, mTOR inhibitors also display immunostimulatory effects, in particular by promoting memory CD8+ T cell generation. Hence, mTOR inhibitors represent a therapeutic opportunity to promote antitumor CD8 responses and to boost the efficacy of different modalities of cancer immunotherapy. In this context, strategies to reduce the immunosuppressive activity of mTOR inhibitors and therefore to shift the immune response toward antitumor immunity will be useful. In this review, we present the different classes of mTOR inhibitors and discuss their effect on immune cells by focusing mainly on CD8+ T cells. We further provide an overview of the different preclinical studies that investigated the anticancer effects of mTOR inhibitors combined to immunotherapies.
Feeling Unsafe at School and Associated Mental Health Difficulties among Children and Adolescents: A Systematic Review
Authors: Mori Yuko , Tiiri Elina , Khanal Prakash , Khakurel Jayden , Mishina Kaisa , Sourander Andre
Published: March 2021

This study systematically reviewed the literature on perceived school safety. We investigated the prevalence, factors and associated mental health difficulties, as well as cross-cultural findings. Five databases were searched up to 9 February 2021 for peer-reviewed papers published in English. We included quantitative studies that explored the perception of school safety among children and adolescents. The reference lists of the selected papers were also searched. We conducted a narrative synthesis of the included studies. The review included 43 papers. The mean prevalence of the students who felt unsafe at school was 19.4% and ranged from 6.1% to 69.1%. Their perceived safety was associated with a wide range of personal, school, and social factors. Not feeling safe at school was related to being victimized and mental health difficulties, including depressive symptoms and suicidal behavior. Higher perceived school safety was associated with measures such as the presence of a security officer and fair school rule enforcement. The results showed the lack of cross-cultural studies on perceived school safety. Empirical studies are needed that examine the mechanisms of school safety, using valid measures. A clear definition of school safety should be considered a key aspect of future studies.
Electro-Optic Control of Lithium Niobate Bulk Whispering Gallery Resonators: Analysis of the Distribution of Externally Applied Electric Fields
Authors: Minet Yannick , Zappe Hans , Breunig Ingo , Buse Karsten
Published: March 2021

Whispering gallery resonators made out of lithium niobate allow for optical parametric oscillation and frequency comb generation employing the outstanding second-order nonlinear-optical properties of this material. An important knob to tune and control these processes is, e.g., the linear electro-optic effect, the Pockels effect via externally applied electric fields. Due to the shape of the resonators a precise prediction of the electric field strength that affects the optical mode is non-trivial. Here, we study the average strength of the electric field in z-direction in the region of the optical mode for different configurations and geometries of lithium niobate whispering gallery resonators with the help of the finite element method. We find that in some configurations almost 100% is present in the cavity compared to the ideal case of a cylindrical resonator. Even in the case of a few-mode resonator with a very thin rim we find a strength of 90%. Our results give useful design considerations for future arrangements that may benefit from the strong electro-optic effect in bulk whispering gallery resonators made out of lithium niobate.
Hyper-Chaotic Color Image Encryption Based on Transformed Zigzag Diffusion and RNA Operation
Authors: Zhang Duzhong , Chen Lexing , Li Taiyong
Published: March 2021

With increasing utilization of digital multimedia and the Internet, protection on this digital information from cracks has become a hot topic in the communication field. As a path for protecting digital visual information, image encryption plays a crucial role in modern society. In this paper, a novel six-dimensional (6D) hyper-chaotic encryption scheme with three-dimensional (3D) transformed Zigzag diffusion and RNA operation (HCZRNA) is proposed for color images. For this HCZRNA scheme, four phases are included. First, three pseudo-random matrices are generated from the 6D hyper-chaotic system. Second, plaintext color image would be permuted by using the first pseudo-random matrix to convert to an initial cipher image. Third, the initial cipher image is placed on cube for 3D transformed Zigzag diffusion using the second pseudo-random matrix. Finally, the diffused image is converted to RNA codons array and updated through RNA codons tables, which are generated by codons and the third pseudo-random matrix. After four phases, a cipher image is obtained, and the experimental results show that HCZRNA has high resistance against well-known attacks and it is superior to other schemes.
Generalized Trust and Economic Growth: The Nexus in MENA Countries
Authors: Miniesy Rania S. , AbdelKarim Mariam
Published: March 2021

This study mainly examines the relationship between generalized/horizontal/social trust and economic growth in countries in the Middle East and North Africa (MENA) region, considering the substantial decline in their trust values since 2005. The study utilizes a multiple linear regression model based on panel data comprising 104 countries over the period from 1999 to 2020. Trust data were obtained from the last four waves of the World Values Survey (WVS). A Pooled Ordinary Least Squares (POLS) estimation technique was used, and interaction terms between trust and several dummy variables were employed. The results show an overall positive and significant relationship between trust and economic growth in the general model and for all country classifications, except for MENA, where the overall relationship is negative but almost negligible. Trust has the highest impact on growth in transition economies, followed in order by developing Asia, developed, developing/Sub-Saharan Africa, developing America, and then MENA countries. Further investigations reveal that the overall negative/reversed effect of trust on economic growth in MENA is only during waves 6 and 7, where the coefficients are sizable.
Association between Building Characteristics and Indoor Environmental Quality through Post-Occupancy Evaluation
Authors: Bortolini Rafaela , Forcada Núria
Published: March 2021

Post-occupancy evaluations are common tools used to periodically assess Indoor Environmental Quality (IEQ) in tertiary buildings. Although the large amount of data collected from surveys contain valuable information, the influence of building characteristics on IEQ considering the different uses of the rooms and different types of occupants is rarely considered in the evaluation. This study presents an analysis of the association between building characteristics and IEQ in different building rooms (classrooms and offices) and different occupants (students and lecturers) using a post occupancy evaluation survey to 1013 occupants in 26 higher educational buildings in Spain under a Mediterranean climate. This research demonstrated that building characteristics influence IEQ perceptions of the different rooms in tertiary education buildings. The possibility of controlling the lighting, shadows or heating, ventilation air or conditioning (HVAC) systems are the most influential factors when analyzing IEQ. The findings of this research are of interest to facility managers aiming at implementing energy efficiency measures based on user-centric satisfaction or developing maintenance plans focused on IEQ enhancement.
Experimental Investigation of a Standalone Wind Energy System with a Battery-Assisted Quasi-Z-Source Inverter
Authors: Bubalo Matija , Bašić Mateo , Vukadinović Dinko , Grgić Ivan
Published: March 2021

This paper presents a wind energy conversion system (WECS) for grid-isolated areas. The system includes a squirrel-cage induction generator (SCIG) and a battery-assisted quasi-Z source inverter (qZSI). The batteries ensure reliable and stable operation of the WECS in spite of the wind power oscillations. The maximum power is captured from both the wind turbine (WT) and the SCIG through adjustment of the WT speed and the SCIG operating flux, respectively. The utilized maximum power point tracking (MPPT) algorithms belong to the group of fuzzy logic (FL) search-based algorithms. The battery state of charge (SOC) is tracked online and controlled. When it reaches the minimum allowed level, the load is automatically disconnected; conversely, when it reaches the maximum allowed level, the battery charging is stopped via WT speed control. The load voltage root-mean-square (RMS) value and frequency are at all times controlled at grid-level values. The performance of the proposed system was experimentally validated, in steady state and during transients, achieving wide ranges of wind speed, load power, SOC, and alternating current/direct current (AC/DC) voltage levels. The system startup and low-wind operation were also analyzed. The control algorithms were executed in real time by means of the DS1103 and MicroLabBox controller boards (dSpace).