bluuebunny/crossref_metadata_2025 huggingface dataset:
Elastisch-stabile intramedulläre Nagelung pertrochantärer Femurfrakturen im Kleinkindesalter (<6 bis 8 Jahre)
Authors: Kaiser N. , Slongo T.
Published: January 2021

Operationsziel

Minimal-invasive, übungsstabile Versorgung von pertrochantären Femurfrakturen bei Kindern < 6 bis 8 Jahren mittels elastisch-stabiler intramedullärer Nagelung (ESIN).

Indikationen

Proximale, pertrochantäre Femurfrakturen Delbet Typ IV bei Kindern < 6 Jahre.

Kontraindikationen

Trümmerfrakturen, Schenkelhalsfrakturen.

Operationstechnik

Durch Einbringen von insgesamt 3 (gelegentlich nur 2) im proximalen Drittel vorgebogenen, elastischen Titannägeln (TEN) retrograd in das Femur wird im proximalen Fragment eine stabile 3‑Punkt-Abstützung erreicht. Eine weitere Verbesserung der Stabilität kann durch die Applikation von Endcaps erreicht werden.

Weiterbehandlung

Die Nachbehandlung erfolgt mittels Sohlenbelastung während 4 bis 5 Wochen. Röntgenkontrollen erfolgen direkt postoperativ sowie nach 4 bis 5 Wochen. Eine Sportunfähigkeit besteht für 3 Monate.

Ergebnisse

In unserem Patientengut haben wir gute Erfahrungen mit dieser Technik bei den sehr seltenen pertrochantären Frakturen bei Kindern < 6 bis 8 Jahren. Mit minimal-invasivem Vorgehen kann eine übungsstabile Versorgung ohne Notwendigkeit eines Becken-Bein-Gipses erreicht werden.
Mediating distributive politics: political alignment and electoral business cycle effects on municipality financing in Greece
Authors: Kitsos Anastasios , Proestakis Antonios
Published: January 2021

We examine the role of political alignment and the electoral business cycle on municipality revenues in Greece for the period 2003–2010. The misallocation of resources for political gain represents a waste of resources with significant negative effects on local growth and effective decentralization. The focus of our analysis is municipality mayors since they mediate the relationship between central government and voters and hence can influence the effectiveness of any potential pork-barrelling activity. A novel panel data set combining the results of two local and three national elections with annual municipality budgets is used to run a fixed-effects econometric model. This allows us to identify whether the political alignment between mayors and central government affects municipality financing. We examine this at different stages of local and national electoral cycles, investigating both direct intergovernmental transfers (grants) and the remaining sources of local revenues (own revenues, loans). We find that total revenues are significantly higher for aligned municipalities in the run-up to elections due to higher intergovernmental transfers. We also find evidence that the 2008 crisis has reduced such pork-barrelling activity. This significant resource misallocation increases vertical networking dependency and calls for policy changes promoting greater decentralization and encouraging innovation in local revenue raising.
Mechanical characterization and properties of laser-based powder bed–fused lattice structures: a review
Authors: Riva Leonardo , Ginestra Paola Serena , Ceretti Elisabetta
Published: January 2021

The increasing demand for a wider access to additive manufacturing technologies is driving the production of metal lattice structure with powder bed fusion techniques, especially laser-based powder bed fusion. Lattice structures are porous structures formed by a controlled repetition in space of a designed base unit cell. The tailored porosity, the low weight, and the tunable mechanical properties make the lattice structures suitable for applications in fields like aerospace, automotive, and biomedicine. Due to their wide-spectrum applications, the mechanical characterization of lattice structures is mostly carried out under compression tests, but recently, tensile, bending, and fatigue tests have been carried out demonstrating the increasing interest in these structures developed by academy and industry. Although their physical and mechanical properties have been extensively studied in recent years, there still are no specific standards for their characterization. In the absence of definite standards, this work aims to collect the parameters used by recent researches for the mechanical characterization of metal lattice structures. By doing so, it provides a comparison guide within tests already carried out, allowing the choice of optimal parameters to researchers before testing lattice samples. For every mechanical test, a detailed review of the process design, test parameters, and output is given, suggesting that a specific standard would enhance the collaboration between all the stakeholders and enable an acceleration of the translation process.
Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors
Authors: Delp Johannes , Cediel-Ulloa Andrea , Suciu Ilinca , Kranaster Petra , van Vugt-Lussenburg Barbara MA , Munic Kos Vesna , van der Stel Wanda , Carta Giada , Bennekou Susanne Hougaard , Jennings Paul , van de Water Bob , Forsby Anna , Leist Marcel
Published: January 2021

Inhibition of complex I of the mitochondrial respiratory chain (cI) by rotenone and methyl-phenylpyridinium (MPP +) leads to the degeneration of dopaminergic neurons in man and rodents. To formally describe this mechanism of toxicity, an adverse outcome pathway (AOP:3) has been developed that implies that any inhibitor of cI, or possibly of other parts of the respiratory chain, would have the potential to trigger parkinsonian motor deficits. We used here 21 pesticides, all of which are described in the literature as mitochondrial inhibitors, to study the general applicability of AOP:3 or of in vitro assays that are assessing its activation. Five cI, three complex II (cII), and five complex III (cIII) inhibitors were characterized in detail in human dopaminergic neuronal cell cultures. The NeuriTox assay, examining neurite damage in LUHMES cells, was used as in vitro proxy of the adverse outcome (AO), i.e., of dopaminergic neurodegeneration. This test provided data on whether test compounds were unspecific cytotoxicants or specifically neurotoxic, and it yielded potency data with respect to neurite degeneration. The pesticide panel was also examined in assays for the sequential key events (KE) leading to the AO, i.e., mitochondrial respiratory chain inhibition, mitochondrial dysfunction, and disturbed proteostasis. Data from KE assays were compared to the NeuriTox data (AO). The cII-inhibitory pesticides tested here did not appear to trigger the AOP:3 at all. Some of the cI/cIII inhibitors showed a consistent AOP activation response in all assays, while others did not. In general, there was a clear hierarchy of assay sensitivity: changes of gene expression (biomarker of neuronal stress) correlated well with NeuriTox data; mitochondrial failure (measured both by a mitochondrial membrane potential-sensitive dye and a respirometric assay) was about 10–260 times more sensitive than neurite damage (AO); cI/cIII activity was sometimes affected at > 1000 times lower concentrations than the neurites. These data suggest that the use of AOP:3 for hazard assessment has a number of caveats: (i) specific parkinsonian neurodegeneration cannot be easily predicted from assays of mitochondrial dysfunction; (ii) deriving a point-of-departure for risk assessment from early KE assays may overestimate toxicant potency.
Inverted internal limiting membrane flap technique in eyes with large idiopathic full-thickness macular hole: long-term functional and morphological outcomes
Authors: Bleidißel Nathalie , Friedrich Julia , Klaas Julian , Feucht Nikolaus , Lohmann Chris Patrick , Maier Mathias
Published: January 2021

Purpose

To investigate morphological and functional outcomes of the inverted internal limiting membrane (I-ILM) flap technique in large (≥ 400 μm) idiopathic full-thickness macular holes (FTMH) over a follow-up period of 12 months.

Methods

In this retrospective study, 55 eyes of 54 consecutive patients were enrolled. Best-corrected visual acuity (BCVA) and spectral-domain optical coherence tomography (SD-OCT, Heidelberg, Spectralis) were performed preoperatively as well as 1, 3, 6, 9, and 12 months postoperatively. Special focus was put on the reintegration of outer retinal layers and the different ILM flap appearances.

Results

FTMH closure rate was 100% (55/55). BCVA significantly improved over the follow-up period of 12 months from 0.98 ± 0.38 LogMAR preoperatively to 0.42 ± 0.33 LogMAR at 12 months postoperatively (p < 0.001). There was no significant correlation between the three different ILM flap appearances and BCVA. Better preoperative BCVA, complete restoration of the external limiting membrane (ELM), higher macular hole index (MHI), and smaller MH base diameter were associated with higher improvement of BCVA.

Conclusion

Our study highlights the favorable morphological and functional outcomes of the I-ILM flap technique in the short as well as in the long term. While complete ELM restoration revealed to be an important factor for improvement in BCVA, the different postoperative ILM flap appearances seem not to be related to BCVA.
Emotion and expertise: how listeners with formal music training use cues to perceive emotion
Authors: Battcock Aimee , Schutz Michael
Published: January 2021

Although studies of musical emotion often focus on the role of the composer and performer, the communicative process is also influenced by the listener’s musical background or experience. Given the equivocal nature of evidence regarding the effects of musical training, the role of listener expertise in conveyed musical emotion remains opaque. Here we examine emotional responses of musically trained listeners across two experiments using (1) eight measure excerpts, (2) musically resolved excerpts and compare them to responses collected from untrained listeners in Battcock and Schutz (2019). In each experiment 30 participants with six or more years of music training rated perceived emotion for 48 excerpts from Bach’s Well-Tempered Clavier (WTC) using scales of valence and arousal. Models of listener ratings predict more variance in trained vs. untrained listeners across both experiments. More importantly however, we observe a shift in cue weights related to training. Using commonality analysis and Fischer Z score comparisons as well as margin of error calculations, we show that timing and mode affect untrained listeners equally, whereas mode plays a significantly stronger role than timing for trained listeners. This is not to say the emotional messages are less well recognized by untrained listeners—simply that training appears to shift the relative weight of cues used in making evaluations. These results clarify music training’s potential impact on the specific effects of cues in conveying musical emotion.
Neurointensive care results and risk factors for unfavorable outcome in aneurysmatic SAH: a comparison of two age groups
Authors: Välimäki Vilja , Luostarinen Teemu , Satopää Jarno , Raj Rahul , Virta Jyri J.
Published: January 2021

Background

The mean age of actively treated subarachnoid hemorrhage (SAH) patients is increasing. We aimed to compare outcomes and prognostic factors between older and younger SAH patients.

Methods

A retrospective single-center analysis of aneurysmal SAH patients admitted to a neuro-ICU during 2014–2019. We defined older patients as ≥70 years and younger patients as <70 years. For every older patient, we identified three younger patients with the same World Federation of Neurological Surgeons (WFNS) grade. We only included patients receiving active aneurysm treatment. Favorable functional outcome, defined as a Glasgow Outcome Scale (GOS) of 4–5 at 12 months, was our primary outcome. We used logistic regression to compare prognostic factors between the groups.

Results

Ninety-five (85%) of 112 older patients and 317 (94%) of 336 younger patients received aneurysm treatment. Of the younger patients, 91% with a good-grade SAH (WFNS I-III) had a favorable outcome compared to 52% in the older good-grade SAH group. In poor-grade patients (WFNS IV-V), favorable outcome was seen in 51% of younger patients, compared to 24% of older patients. Acute hydrocephalus and intracerebral hemorrhage were associated with unfavorable outcome in the younger (OR 4.7, 95% CI 2.6–8.4, and OR 3.7, 95% CI 2.1–6.4), but not in the older patients (OR 1.8, 95% CI 0.8–4.2, and OR 1.3, 95% CI 0.5–3.1, respectively).

Conclusions

In actively treated SAH patients, age was a major determinant of outcome. Factors reflecting increases in intracranial pressure associated with outcome only among younger patients.
A formal approach to finding inconsistencies in a metamodel
Authors: Wu Hao , Farrell Marie
Published: January 2021

Checking the consistency of a metamodel involves finding a valid metamodel instance that provably meets the set of constraints that are defined over the metamodel. These constraints are often specified in Object Constraint Language. Often, a metamodel is inconsistent due to conflicts among the constraints. Existing approaches and tools are typically incapable of pinpointing the conflicting constraints, and this makes it difficult for users to debug and fix their metamodels. In this paper, we present a formal approach for locating conflicting constraints in inconsistent metamodels. Our approach has four distinct features: (1) users can rank individual metamodel features using their own domain-specific knowledge, (2) we transform these ranked features to a weighted maximum satisfiability modulo theories problem and solve it to compute the set of maximum achievable features, (3) we pinpoint the conflicting constraints by solving the set cover problem using a novel algorithm, and (4) we have implemented our approach into a fully automated tool called MaxUSE. Our evaluation results, using our assembled set of benchmarks, demonstrate the scalability of our work and that it is capable of efficiently finding conflicting constraints.
Social relationships as predictors of extended employment beyond the pensionable age: a cohort study
Authors: Kauppi M. , Prakash K. C. , Virtanen M. , Pentti J. , Aalto V. , Oksanen T. , Kivimäki M. , Vahtera J. , Stenholm S.
Published: January 2021

The aim is to examine whether characteristics of social relationships predict extended employment beyond the pensionable age among Finnish public sector workers. The study population consisted of 4014 participants (83% women, age 62.56 ± 1.21) of the Finnish Retirement and Aging Study followed between 2014 and 2019. Extended employment was defined as the difference between actual retirement date and individual age-related pensionable date and classified into three groups: no extension (retired on pensionable age or extended by < 3 months), short extension (3 months–< 1 year), and long extension (≥ 1 year) beyond the pensionable date. Characteristics of social relationships and engagement were assessed 18 months prior to the pensionable date. Social engagement was classified into consumptive social participation, formal social participation, informal social participation, and other social participation. Data were analyzed using multinomial regression analysis. Of total study participants, 17.8% belonged to short- and 16.5% belonged to long-extension group. Adjusted for age, occupational status, self-rated health and depression, and having a working spouse (OR 2.34, 95% CI 1.39–3.95) were associated with long extension of employment beyond the pensionable age when compared to no extension among men. Likewise, among women, living alone (OR 1.60, 95% CI 1.28–2.00), having a working spouse (1.85, 1.39–2.45), and high consumptive (1.32, 1.07–1.65), high formal (1.47, 1.17–1.85), and other social participation (0.79, 0.63–0.98) were associated with long extension. Having a working spouse, living alone, and high consumptive social participation were associated with short extension. Several characteristics of social relationships, such as having a working spouse, living alone, and high frequency of social engagement, predicted an extension of employment beyond the pensionable age.
Development of an Intervention Aimed at Increasing Awareness and Acknowledgement of Victimisation and Its Consequences Among People with Severe Mental Illness
Authors: Albers Wendy M. M. , Nijssen Yolanda A. M. , Roeg Diana P. K. , Bongers Inge M. B. , van Weeghel Jaap
Published: January 2021

Individuals with severe mental illness have a significant risk of (anticipated) discrimination and (criminal) victimisation, which is not structurally and systematically addressed by mental health practitioners. The aim of this study was to develop and pilot an intervention which supports professionals to address victimisation and its consequences, in order to reinforce safe social participation and improve recovery. Following the rehabilitation and positive risk management literature, in addition to current practice, intervention components were developed in two focus groups and four subsequent expert meetings. The intervention was piloted in two outpatient teams before being finalised. The Victoria intervention includes positive risk management, focusing on clients’ narratives and strengths, and awareness of unsafe (home) environments: it comprises four steps: exploring issues with social participation, analysing victimisation experiences, clarifying the context of these experiences, and determining future steps, including victimisation-sensitive rehabilitation planning and optional trauma treatment. Future research should further test this intervention.
Transition radiation in a nonlinear and infinite one-dimensional structure: a comparison of solution methods
Authors: Fărăgău Andrei B. , Keijdener Chris , de Oliveira Barbosa João M. , Metrikine Andrei V. , van Dalen Karel N.
Published: January 2021

Transition zones in railway tracks are locations with a significant variation of track properties (i.e. foundation stiffness) encountered near structures such as bridges and tunnels. Due to strong amplification of the track’s response, transition zones are prone to rapid degradation. To investigate the degradation mechanisms in transition zones, researchers have developed a multitude of models, some of them being very complex. This study compares three solution methods, namely an integral-transform method, a time-domain method, and a hybrid method, with the goal of solving these systems efficiently. The methods are compared in terms of accuracy, computational efficiency, and feasibility of application to more complex systems. The model employed in this paper consists of an infinite, inhomogeneous, and piecewise-linear 1-D structure subjected to a moving constant load. Although the 1-D model is not particularly demanding computationally, it is used to make qualitative observations as to which method is most suitable for the 2-D and 3-D models, which could lead to significant gains. Results show that all three methods can reach similar accuracy levels, and in doing so, the time-domain method is most computationally efficient. The integral-transform method appears to be efficient in dealing with frequency-dependent parameters, while the time-domain and hybrid methods are efficient in dealing with a smooth nonlinearity. For multi-dimensional models, if nonlinearities and inhomogeneities are considered throughout the depth, the time-domain method is likely to be most efficient; however, if nonlinearities and inhomogeneities are limited to the surface layers, the integral-transform and hybrid methods have the potential to be more efficient than the time-domain one. Finally, although the 1-D model presented in this study is mainly used to assess the three methods, it can also be used for preliminary designs of transition zones in railway tracks.
Broad bracketing for low probability events
Authors: Chaudhry Shereen J. , Hand Michael , Kunreuther Howard
Published: January 2021

Individuals tend to underprepare for rare, catastrophic events because of biases in risk perception. A simple form of broad bracketing—presenting the cumulative probability of loss over a longer time horizon—has the potential to alleviate these barriers to accurate risk perception and increase protective actions such as purchasing flood insurance. However, it is an open question whether broad bracketing effects last over time: There is evidence that descriptive probability information is ignored when decisions are based on “experience” (repeatedly and in the face of feedback), which characterizes many protective decisions. Across six incentive-compatible experiments with high stakes, we find that the broad bracketing effect doesnotdisappear or change size when decisions are made from experience. We also advance our understanding of the mechanisms underlying broad bracketing, finding that, while cumulative probability size is a strong driver of the effect, this is dampened for larger brackets leading people to be less sensitive to probability size.
Oxylipins at intermediate larval stages of damselfly Coenagrion hastulatum as biochemical biomarkers for anthropogenic pollution
Authors: Späth Jana , Brodin Tomas , Cerveny Daniel , Lindberg Richard , Fick Jerker , Nording Malin L.
Published: January 2021

Aquatic pollution resulting from anthropogenic activities requires adequate environmental monitoring strategies in sentinel organisms. Thus, biochemical biomarkers have been used as early-warning tools of biological effects in aquatic organisms. However, before using these markers for environmental monitoring, knowledge about their developmental variation is vital. In this study, we assessed baseline levels and developmental variations of a group of potential biomarkers, oxylipins, during the lifespan of the Northern damselfly (Coenagrion hastulatum) using liquid chromatography-tandem mass spectrometry. Effects of wastewater exposure on baseline levels were studied in a subset of damselflies to investigate the responsiveness due to anthropogenic pollution. Thirty-eight oxylipins deriving from four polyunsaturated fatty acids via two enzymatic pathways were detected in damselflies at three larval stages and in the adult form. Overall, oxylipin baseline levels showed developmental variation, which was lowest in the intermediate larval stages. Effects of exposure to wastewater effluent on oxylipin baseline levels were dependent on the life stage and were greatest in the early and intermediate larval stages. The study provides first insights into oxylipin profiles of damselflies at different stages of development and their developmental variation. Based on our results, we propose further strategies for incorporating oxylipins in damselfly larvae as biochemical markers for anthropogenic pollution.

Graphical abstract
Zusammenhänge zwischen verhaltensbezogenen und somatischen Facetten von Resilienz bei Arbeitnehmern/-innen der Automobilzuliefererindustrie
Authors: Friederichs Edgar , Kärner Tobias , Schellinger Bianca , Sembill Detlef
Published: January 2021

Hintergrund und Zielstellung

Ausgehend von einem mittels Selbstauskunft erfassten Resilienzkonstrukt, welches die Verhaltensweisen beschreibt, (1) dynamisch Veränderungen gestalten zu können, (2) flexibel auf Erfordernisse reagieren zu können sowie (3) sich angemessen von den Erwartungen anderer abgrenzen zu können, setzt sich der Beitrag das Ziel, Zusammenhänge mit kardialen Indikatoren des autonomen Nervensystems (ANS) zu ermitteln.

Methodik

Wir greifen auf Daten von insgesamt 150 Mitarbeiter/-innen (MA) eines deutschen Industrieunternehmens zurück, von welchen sowohl entsprechende Selbstauskunftsdaten als auch Messdaten der Aktivität des ANS erfasst wurden.

Ergebnisse

In den Ergebnissen zeigen sich signifikante Korrelationen der Resilienzfacette „Dynamik“ mit parasympathischen Messparametern des ANS. Weiterhin zeigt sich, dass die Facette „Dynamik“ in signifikant negativem Zusammenhang mit verschiedenen Skalen des „Trierer Inventars zum chronischen Stress“ steht. Ältere MA weisen bei der Facette „Dynamik“ verglichen mit jüngeren MA tendenziell geringere Werte auf. MA, welche eine Führungsaufgabe mit disziplinarischer und/oder fachlicher Funktion innehaben, zeigen höhere Werte in dieser Facette, verglichen mit MA ohne entsprechende Führungsverantwortung.

Diskussion

Messbare Daten für eine wissenschaftlich gestützte Prävention und Resilienzunterstützung sind ein innovativer und vielversprechender Ansatz. Die Anwendung geprüfter Messverfahren kann auch für Leistungsfähigkeit, Erfolg und Wettbewerbsfähigkeit eines Unternehmens wichtig sein. Aus den Strukturähnlichkeiten der verhaltensbezogenen und somatischen Resilienzfacetten ergeben sich gezielte Implikationen für die Resilienzerfassung in Arbeitskontexten. Entsprechende Anschlussfragen hinsichtlich personen- und organisationsspezifischer Trainings zur Resilienzförderung müssen in Folgestudien geklärt werden.
A computable general equilibrium analysis of environmental tax reform in Japan with a forward-looking dynamic model
Authors: Takeda Shiro , Arimura Toshi H.
Published: January 2021

The Japanese government plans to reduce greenhouse gas emissions by 80% by 2050. However, it is not yet clear which policy measures the government will adopt to achieve this goal. In this regard, environmental tax reform, which is the combination of carbon regulation and the reduction of existing distortionary taxes, has attracted much attention. This paper examines the effects of an environmental tax reform in Japan. Using a dynamic computable general equilibrium (CGE) model, we analyze the quantitative impacts of an environmental tax reform and clarify which types of environmental tax reform are the most desirable. In the simulation, we introduce a carbon tax and consider the following four scenarios for the use of the carbon tax revenue: (1) a lump-sum rebate to the household, (2) a cut in income taxes, (3) a cut in corporate taxes and (4) a cut in consumption taxes. The first scenario is a pure carbon tax, and the other three scenarios are types of environmental tax reform. Our CGE simulation shows that (1) environmental tax reform tends to generate more desirable impacts than the pure carbon tax and that (2) the strong double dividend is obtained in some cases. In particular, we show that a cut in corporate taxes leads to the most desirable policy in terms of GDP and national income.
Altered structural connectivity networks in dementia with lewy bodies
Authors: Nicastro Nicolas , Mak Elijah , Surendranathan Ajenthan , Rittman Timothy , Rowe James B. , O’Brien John T.
Published: January 2021

The impairment of large-scale brain networks has been observed in dementia with Lewy bodies (DLB) using functional connectivity, but the potential for an analogous effect on structural covariance patterns has not been determined. Twenty-four probable DLB subjects (mean age 74.3 ± 6.7 years, 16.7% female) and 23 similarly aged Controls were included. All participants underwent 3T MRI imaging with high-resolution T1-weighted magnetization-prepared rapid gradient echo (MPRAGE) sequence. Graph theoretical analyses were performed using variation in regional cortical thickness to construct a structural association matrix with pairwise Pearson correlations. Global and nodal graph parameters were computed to assess between-group differences and community structure was studied in order to quantify large-scale brain networks in both groups. In comparison to Controls, DLB subjects had decreased global efficiency, clustering, modularity and small-worldness of structural networks (all p < 0.05). Nodal measures showed that DLB subjects also had decreased clustering in bilateral temporal regions and decreased closeness centrality in extensive areas including right middle frontal, left cingulate and bilateral occipital lobe (all false-discovery rate (FDR)-corrected q < 0.05). Whereas four distinct modules could be clearly identified in Controls, DLB showed extensively disorganized modules, including default-mode network and dorsal attentional network. Our results suggest a marked impairment in large-scale brain structural networks in DLB, mirroring functional connectivity networks disruption.
Supporting international networks through platforms for standardised data collection—the European Registries for Rare Endocrine Conditions (EuRRECa) model
Authors: Ali S. R. , Bryce J. , Smythe C. , Hytiris M. , Priego A. L. , Appelman-Dijkstra N. M. , Ahmed S. F.
Published: January 2021

Rare endocrine pathology is manifested by either a deficiency or excess of one or more hormones. These conditions can be life-threatening and are almost universally associated with long-term morbidity. Understanding the aetiology of these conditions requires multicentre collaboration and expertise, most often across national boundaries, with the capacity for long-term follow-up. The EuRRECa (European Registries for Rare Endocrine Conditions) project (www.eurreca.net), funded by the EU Health Programme, aims to support the needs of the wider endocrine community by maximising the opportunity for collaboration between patients, health care professionals and researchers across Europe and beyond. At the heart of the EuRRECa collaboration is a Core Endocrine Registry that collects a core dataset for all rare endocrine conditions that are covered within Endo-ERN. The registry incorporates patient reported markers of clinical outcome and will signpost participants to high-quality, disease-specific registries. Furthermore, an electronic surveillance programme (e-REC) captures clinical activity and epidemiology for these rare conditions. EuRRECa receives guidance compliant with the highest ethical standards from Expert Working Groups that align with the Main Thematic Groups of Endo-ERN. Security, data quality and data governance are cornerstones of this platform. Clear policies that are acceptable to patients, researchers and industry for data governance coupled with widespread dissemination and knowledge exchange through closely affiliated stakeholders will ensure sustainability beyond the current lifetime of the project. This paper describes the infrastructure that has been developed, stakeholder involvement, the data fields that are captured within the registry and details on the process for using the platform.
Clinical management of patients with genetic obesity during COVID-19 pandemic: position paper of the ESE Growth & Genetic Obesity COVID-19 Study Group and Rare Endo-ERN main thematic group on Growth and Obesity
Authors: De Groot Cornelis Jan , Poitou Bernert Christine , Coupaye Muriel , Clement Karine , Paschou Stavroula A. , Charmandari Evangelia , Kanaka-Gantenbein Christina , Wabitsch Martin , Buddingh Emilie P. , Nieuwenhuijsen Barbara , Marina Ljiljana , Johannsson Gudmundur , Van Den Akker E. L. T.
Published: January 2021

This article aims to provide guidance on prevention and treatment of COVID-19 in patients with genetic obesity. Key principals of the management of patients with genetic obesity during COVID-19 pandemic for patients that have contracted COVID-19 are to be aware of: possible adrenal insufficiency (e.g., POMC deficiency, PWS); a more severe course in patients with concomitant immunodeficiency (e.g., LEP and LEPR deficiency), although defective leptin signalling could also be protective against the pro-inflammatory phenotype of COVID-19; disease severity being masked by insufficient awareness of symptoms in syndromic obesity patients with intellectual deficit (in particular PWS); to adjust medication dose to increased body size, preferably use dosing in m2; the high risk of malnutrition in patients with Sars-Cov2 infection, even in case of obesity. Key principals of the obesity management during the pandemic are to strive for optimal obesity management and a healthy lifestyle within the possibilities of the regulations to prevent weight (re)gain and to address anxiety within consultations, since prevalence of anxiety for COVID-19 is underestimated.
ENDO-ERN expert opinion on the differential diagnosis of pubertal delay
Authors: Persani Luca , Bonomi Marco , Cools Martine , Dattani Mehul , Dunkel Leo , Gravholt Claus H. , Juul Anders
Published: January 2021

The differential diagnoses of pubertal delay include hypergonadotropic hypogonadism and congenital hypogonadotropic hypogonadism (CHH), as well as constitutional delay of growth and puberty (CDGP). Distinguishing between CDGP and CHH may be challenging, and the scientific community has been struggling to develop diagnostic tests that allow an accurate differential diagnosis. Indeed, an adequate and timely management is critical in order to enable optimal clinical and psychosocial outcomes of the different forms of pubertal delays. In this review, we provide an updated insight on the differential diagnoses of pubertal delay, including the available tests, their meanings and accuracy, as well as some clues to effectively orientate towards either constitutional pubertal delay or pathologic CHH and hypergonadotropic hypogonadism.
Effect of interleukin-6, -17, -21, -22, and -23 and STAT3 on signal transduction pathways and their inhibition in autoimmune arthritis
Authors: Woś Izabela , Tabarkiewicz Jacek
Published: January 2021

Rheumatic diseases are complex autoimmune diseases which include among others rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), and psoriatic arthritis (PsA). These diseases are characterized by prolonged and increased secretion of inflammatory factors, eventually leading to inflammation. This is often accompanied by persistent pain and stiffness in the joint and finally bone destruction and osteoporosis. These diseases can occur at any age, regardless of gender or origin. Autoimmune arthritis is admittedly associated with long-term treatment, and discontinuation of medication is associated with unavoidable relapse. Therefore, it is important to detect the disease at an early stage and apply appropriate preventative measures. During inflammation, pro-inflammatory factors such as interleukins (IL)-6, -17, -21, -22, and -23 are secreted, while anti-inflammatory factors including IL-10 are downregulated. Research conducted over the past several years has focused on inhibiting inflammatory pathways and activating anti-inflammatory factors to improve the quality of life of people with rheumatic diseases. The aim of this paper is to review current knowledge on stimulatory and inhibitory pathways involving the signal transducer and activator of transcription 3 (STAT3). STAT3 has been shown to be one of the crucial factors involved in inflammation and is directly linked with other pro-inflammatory factors and thus is a target of current research on rheumatoid diseases.
Prevalence of nonalcoholic fatty liver disease in mental disorder inpatients in China: an observational study
Authors: Ma Qiuyue , Yang Fude , Ma Botao , Jing Wenzhan , Liu Jue , Guo Moning , Li Juan , Wang Zhiren , Liu Min
Published: January 2021

Background and Purpose

Non-alcoholic fatty liver disease (NAFLD) is becoming the most common liver disease in China. However, the understanding of NAFLD prevalence among Chinese mental disorder inpatients remains insufficient. We aim to investigate the prevalence of NAFLD among mental disorder inpatients in Beijing, China.

Methods

In this observational study, we included 66,273 mental disorder inpatients between 2014 and 2018, including inpatients with schizophrenia, bipolar disorder, depressive disorder and other mental disorders. Data were obtained from electronic health records of 19 specialized psychiatric hospitals in Beijing. NAFLD was defined by ICD-10 code, excluding other causes of liver disease. We calculated the overall and annual prevalence rates of NAFLD from 2014 to 2018, and compared NAFLD prevalence between sexes, age groups, mental disorders types, antipsychotics use, and comorbidities. Multivariable logistic regression was used to examine risk factors associated with NAFLD. Subgroup analysis was performed in different mental disorder types.

Results

The prevalence of NAFLD was 17.63% (95% CI 17.34–17.92%) in mental disorder inpatients, increasing from 16.88% in 2014 to 19.07% in 2018. The NAFLD prevalence in participants with schizophrenia (22.44%) was higher than that in participants with bipolar disorder (17.89%), depressive disorder (12.62%), and other mental disorders (12.99%). Women had similar or even higher NAFLD prevalence than men after 50 years. Men, 50–59 years (aOR = 1.71), schizophrenia (aOR = 1.56), bipolar disorder (aOR = 1.47), antipsychotics use (aOR = 1.46), hypertension (aOR = 1.50), diabetes (aOR = 1.83), dyslipidemia (aOR = 2.50) were risk factors for NAFLD in mental disorder inpatients.

Conclusion

NAFLD was common among Chinese mental disorder inpatients, and increased over years. The prevalence of NAFLD was higher among men, old women, inpatients with schizophrenia, bipolar disorder, antipsychotics, hypertension, diabetes, and dyslipidemia. Fatty liver disease among mental disorder population warrants the attention of psychiatric specialists and health policy-makers.
Robustness of life histories to environmental variability in complex versus simple life cycles
Authors: Jonsson Annie
Published: January 2021

Most animal species have a complex life cycle (CLC) with metamorphosis. It is thus of interest to examine possible benefits of such life histories. The prevailing view is that CLC represents an adaptation for genetic decoupling of juvenile and adult traits, thereby allowing life stages to respond independently to different selective forces. Here I propose an additional potential advantage of CLCs that is, decreased variance in population growth rate due to habitat separation of life stages. Habitat separation of pre- and post-metamorphic stages means that the stages will experience different regimes of environmental variability. This is in contrast to species with simple life cycles (SLC) whose life stages often occupy one and the same habitat. The correlation in the fluctuations of the vital rates of life stages is therefore likely to be weaker in complex than in simple life cycles. By a theoretical framework using an analytical approach, I have (1) derived the relative advantage, in terms of long-run growth rate, of CLC over SLC phenotypes for a broad spectrum of life histories, and (2) explored which life histories that benefit most by a CLC, that is avoid correlation in vital rates between life stages. The direction and magnitude of gain depended on life history type and fluctuating vital rate. One implication of our study is that species with CLCs should, on average, be more robust to increased environmental variability caused by global warming than species with SLCs.
A Markov-switching dynamic regression analysis of the asymmetries related to the determinants of US crude oil production between 1982 and 2019
Authors: Temkeng Serge Djoudji , Fofack Achille Dargaud
Published: January 2021

The structural changes brought about by shale oil revolution have inspired this paper of which the aim is to analyze the potential asymmetries related to the determinants of crude oil production in the USA. Thus, using a Markov-switching dynamic regression model in which parameters change when oil production moves from one regime to the other, it is found that for both oil production and oil relative importance, the regime that was dominant during the 1980s and the early 1990s when oil production in the USA was substantially high is the same regime that has once again become dominant in the decade corresponding to the shale oil revolution. Furthermore, the study reveals the existence of asymmetries in the relationship between US crude oil production and both manufacturing production and the consumer price index. Asymmetries are also found in the relationship between the relative importance US crude oil and manufacturing production. Finally, it is found that the intercept and the variance parameter also vary from one regime to the other, thus justifying the use of regime-dependent models.
Investigation of Spatial and Temporal Salinity Distribution in a River Dominated Delta through Idealized Numerical Modelling
Authors: Matsoukis Constantinos , Amoudry Laurent O. , Bricheno Lucy , Leonardi Nicoletta
Published: January 2021

The world’s river deltas are increasingly vulnerable due to pressures from human activities and environmental change. In deltaic regions, the distribution of salinity controls the resourcing of fresh water for agriculture, aquaculture and human consumption; it also regulates the functioning of critical natural habitats. Despite numerous insightful studies, there are still significant uncertainties on the spatio-temporal patterns of salinity across deltaic systems. In particular, there is a need for a better understanding of the salinity distribution across deltas’ channels and for simple predictive relationships linking salinity to deltas’ characteristics and environmental conditions. We address this gap through idealized three-dimensional modelling of a typical river-dominated delta configuration and by investigating the relationship between salinity, river discharge and channels’ bifurcation order. Model results are then compared with real data from the Mississippi River Delta. Results demonstrate the existence of simple one-dimensional and analytical relationships describing the salinity field in a delta. Salinity and river discharge are exponentially and negatively correlated. The Strahler-Horton method for stream labelling of the delta channels was implemented. It was discovered that salinity increases with decreasing stream order. These useful relationships between salinity and deltas’ bulk features and geometry might be applied to real case scenarios to support the investigation of deltas vulnerability to environmental change and the management of deltaic ecosystems.
Preoperatively diagnosed gastric collision tumor with mixed adenocarcinoma and gastrointestinal stromal tumor: a case report and literature review
Authors: Matsuno Kunihiko , Kanazawa Yoshikazu , Kakinuma Daisuke , Hagiwara Nobutoshi , Ando Fumihiko , Masuda Yuka , Fujita Itsuo , Arai Hiroki , Nomura Tsutomu , Kato Shunji , Yoshiyuki Toshiro , Peng Wei-Xia , Yoshida Hiroshi
Published: January 2021

Reports of gastric collision tumors, comprising adenocarcinoma and gastrointestinal stromal tumor, are extremely rare. Here, we report the case of a 68-year-old male who was diagnosed with a lower-body, moderately differentiated, tubular-type adenocarcinoma and submucosal tumor and underwent an elective D2 distal gastrectomy. The tumor cells of the gastrointestinal stromal tumor were positive for H-caldesmon and CD117, weakly positive for smooth muscle actin and DOG-1, and negative for desmin, S-100 protein, CD31, and AE1/AE3. The tumor had grown into a mixed form of adenocarcinoma and gastrointestinal stromal tumor. Thus, we report the first case of a preoperatively diagnosed collision tumor in the stomach consisting of adenocarcinoma and gastrointestinal stromal tumor.
The Threats of Artificial Intelligence Scale (TAI)
Authors: Kieslich Kimon , Lünich Marco , Marcinkowski Frank
Published: January 2021

In recent years Artificial Intelligence (AI) has gained much popularity, with the scientific community as well as with the public. Often, AI is ascribed many positive impacts for different social domains such as medicine and the economy. On the other side, there is also growing concern about its precarious impact on society and individuals, respectively. Several opinion polls frequently query the public fear of autonomous robots and artificial intelligence, a phenomenon coming also into scholarly focus. As potential threat perceptions arguably vary with regard to the reach and consequences of AI functionalities and the domain of application, research still lacks necessary precision of a respective measurement that allows for wide-spread research applicability. We propose a fine-grained scale to measure threat perceptions of AI that accounts for four functional classes of AI systems and is applicable to various domains of AI applications. Using a standardized questionnaire in a survey study (N = 891), we evaluate the scale over three distinct AI domains (medical treatment, job recruitment, and loan origination). The data support the dimensional structure of the proposed Threats of AI (TAI) scale as well as the internal consistency and factoral validity of the indicators. Implications of the results and the empirical application of the scale are discussed in detail. Recommendations for further empirical use of the TAI scale are provided.
Melatonin Improves Drought Resistance in Maize Seedlings by Enhancing the Antioxidant System and Regulating Abscisic Acid Metabolism to Maintain Stomatal Opening Under PEG-Induced Drought
Authors: Li Zhuo , Su Xiaoyu , Chen Yulu , Fan Xiaocong , He Lingzhi , Guo Jiameng , Wang Yongchao , Yang Qinghua
Published: January 2021

Maize (Zea mays L.) is highly sensitive to drought stress, resulting in large losses in yield; therefore, strategies aimed at enhancing drought tolerance are essential. Melatonin improves stress tolerance in plants; however, its mechanism in maize seedlings under drought stress remains unknown. Therefore, we investigated the effects of foliar-sprayed melatonin (100 umol L−1) on the antioxidant system, photosynthetic gas exchange parameters, stomatal behavior, endogenous melatonin and abscisic acid (ABA)-related gene expression in maize seedling leaves under 20% polyethylene glycol (PEG)-induced drought stress. PEG treatment resulted in oxidative stress and stomatal closure, resulting in chlorophyll degradation and inhibition of photosynthesis; thereby, reducing seedling biomass. Melatonin pretreatment significantly improved the relative water content, photosynthetic gas exchange parameters and stomatal behavior; thereby, maintaining chlorophyll contents and photosynthesis. Melatonin also stimulated the antioxidant system, enhancing the clearance of reactive-oxygen species, preventing severe damage under PEG-induced drought. Pre-treatment also increased endogenous melatonin and inhibited up-regulation of NCED1, an ABA synthesis-related gene, as well as selectively up-regulating ABA catabolic genes ABA8ox1 and ABA8ox3, reducing ABA accumulation and inducing stomatal reopening. Overall, these findings suggest that melatonin pre-treatment alleviated the inhibitory effects of drought stress on photosynthesis, enhancing tolerance in maize seedlings.
Application of big data in healthcare: examination of the military experience
Authors: Berry David
Published: January 2021

Healthcare is fully embracing the promise of Big Data for improving performance and efficiency. Such a paradigm shift, however, brings many unforeseen impacts both positive and negative. Healthcare has largely looked at business models for inspiration to guide model development and practical implementation of Big Data. Business models, however, are limited in their application to healthcare as the two represent a complicated system versus a complex system respectively. Healthcare must, therefore, look toward other examples of complex systems to better gauge the potential impacts of Big Data. Military systems have many similarities with healthcare with a wealth of systems research, as well as practical field experience, from which healthcare can draw. The experience of the United States Military with Big Data during the Vietnam War is a case study with striking parallels to issues described in modern healthcare literature. Core principles can be extracted from this analysis that will need to be considered as healthcare seeks to integrate Big Data into its active operations.