bluuebunny/crossref_metadata_2025 huggingface dataset:
Mechanism Underlying the Immune Responses of a Sublingual Vaccine for SARS-CoV-2 with RBD Antigen and Adjuvant, Poly(I:C) or AddaS03, in Non-human Primates
Authors: Yamamoto Tetsuro , Mitsunaga Fusako , Wasaki Kunihiko , Kotani Atsushi , Tajima Kazuki , Tanji Masanori , Nakamura Shin
Published: May 2023

A sublingual vaccine formulated with recombinant SARS-CoV-2 spike protein receptor binding domain (RBD) antigen and Poly(I:C)) adjuvant was assessed for its safety in non-human primates. This Poly(I:C)-adjuvanted sublingual vaccine was safe compared to the AddaS03-adjuvanted vaccine in blood tests and plasma CRP. The safety of the vaccine was also confirmed through quantitative reverse transcription PCR of six genes and ELISA of four cytokines associated with inflammation and related reactions. The Poly(I:C)- or AddaS03-adjuvanted sublingual vaccine produced RBD-specific IgA antibodies in nasal washings, saliva, and plasma. SARS-CoV-2 neutralizing antibodies were detected in plasma, suggesting that adjuvanted-sublingual vaccines protect against SARS-CoV-2 infection. “Yin and Yang”-like unique transcriptional regulation was observed through DNA microarray analyses of white blood cell RNAs from both vaccines, suppressing and enhancing immune responses and up- or downregulating genes associated with these immune responses. Poly(I:C) adjuvanted sublingual vaccination induced atypical up- or downregulation of genes related to immune suppression or tolerance; Treg differentiation; and T-cell exhaustion. Therefore, Poly(I:C) adjuvant is safe and favorable for sublingual vaccination and can induce a balanced “Yin/Yang” -like effect on immune responses.
Clonal Hematopoiesis of Indeterminate Potential in Patients with Chronic Thromboembolic Pulmonary Hypertension
Authors: Liu Chao , Cheng Chun-Yan , Lian Tian-Yu , Zhou Yu-Ping , Yang Yin-Jian , Zhang Si-Jin , Wei Yun-Peng , Zhu Yong-Jian , Qiu Lu-Hong , Qiu Bao-Chen , Ren Li-Yan , Ma Jing-Si , Li Ruo-Nan , Wang Jia , Shen Ying-Hui-Zi , Han Zhi-Yan , Li Jing-Hui , Zhao Qin-Hua , Wang Lan , Xu Xi-Qi , Sun Kai , Wang Duo-Lao , Zhang Ze-Jian , Jing Zhi-Cheng
Published: May 2023

Background

The pathogenesis of chronic thromboembolic pulmonary hypertension (CTEPH) is complex and multifactorial, with growing evidence indicating the involvement of hematologic disorders. Clonal hematopoiesis of indeterminate potential (CHIP) has recently been associated with increased risks of both hematologic malignancies and cardiovascular diseases. The CHIP in patients with CTEPH and its clinical relevance remain undetermined.

Methods

We performed a step-wise calling method on the next-generation sequencing data from 499 CTEPH patients referred to three centers between October 2006 and December 2021 to identify CHIP mutations. We associated CHIP with all-cause mortality in patients with CTEPH. To provide potential mechanistic insights, the associations between CHIP and inflammation characteristics reflected by circulating cytokines and IgG galactosylation, a hallmark of inflammatory state in diseases were also determined.

Results

Total 51 (10.2%) patients with CTEPH carried at least one CHIP mutation at a variant allele frequency of ≥ 2%, and the most common mutations were amongDNMT3A,RUN1andSTAG2. During a mean follow-up time of 55 months, deaths occurred in 21 patients (42.9%) in the CHIP group and 105 patients (24.3%) in the non-CHIP group, contributing to the 5-year survival rate of 65.3% in the CHIP group and 81.9% in the non-CHIP group (P< 0.001 for log-rank test). The association of CHIP with mortality remained robust in the fully adjusted model (HR: 3.447; 95% CI: 1.747 – 6.803;P< 0.001). Besides, patients in the CHIP group showed higher circulating IL-1beta and IL-6 and lower IL-4 and IgG galactosylation compared with the non-CHIP group.

Conclusions

CHIP is enriched in CTEPH patients and is associated with a worse prognosis in CTEPH. Mechanically, patients in the CHIP group showed a more severe inflammatory state.

Clinical Perspective

What is new?

Clonal hematopoiesis of indeterminate potential (CHIP) mutations are enriched in chronic thromboembolic pulmonary hypertension (CTEPH) patients, with most common mutated genes beingDNMT3A,RUN1andSTAG2.

CHIP is associated with worse clinical outcomes in CTEPH.

CHIP is associated with more severe inflammation state mediated by myeloid as well as lymphoid cells in patients with CTEPH.

What are the clinical implications?

CHIP might be a risk factor for CTEPH, suggesting a relationship between CTEPH and hematopoietic disorders.

CHIP represented an additional disease component in CTEPH that independently impacts prognosis.

CHIP might be a potential target for personalized medicine and an indicator of benefit from anti-inflammatory therapies for CTEPH patients.
Intravenous thrombolysis prior to endovascular treatment in posterior circulation occlusions; a MR CLEAN Registry study
Authors: Knapen R.R.M.M. , Pirson F.A.V. , Langezaal L.C.M. , Brouwer J. , Majoie C.B. , Emmer B.J. , Vos J.A. , van Doormaal P.J. , Yoo A.J. , Bruggeman A.A.E. , Nijeholt G.J. Lycklama à , van der Leij C. , van Oostenbrugge R.J. , van Zwam W.H. , Schonewille W.J.
Published: May 2023

Background and aims

The effectiveness of intravenous thrombolysis (IVT) prior to endovascular treatment (EVT) has been investigated in randomized trials and meta-analyses. These studies mainly concerned anterior circulation occlusions. We aimed to investigate clinical, technical, and safety outcomes of IVT prior to EVT in posterior circulation occlusions in a nationwide registry.

Methods

Patients were included from the MR CLEAN Registry: a nationwide, prospective, multicenter registry of patients with acute ischemic stroke (AIS) due to a large intracranial vessel occlusion receiving EVT between 2014 and 2019. All patients with a posterior circulation occlusion were included. Primary outcome was a shift towards better functional outcome on the modified Rankin scale (mRS) at 90 days. Secondary outcomes were favorable functional outcome (mRS 0-3), occurrence of symptomatic intracranial hemorrhages (sICH), successful reperfusion (eTICI≥2B), first-attempt successful reperfusion, and mortality at 90 days. Regression analyses with adjustments based on univariate analyses and literature were applied.

Results

A total of 248 patients were included, who received either IVT (n=125) or no IVT (n=123) prior to EVT. Results show no differences in a shift on the mRS (acOR:1.04, 95%CI:0.61-1.76). Although sICH occurred more often in the IVT group (4.8% versus 2.4%), regression analysis did not show a significant difference (aOR:1.65, 95%CI:0.33-8.35). Successful reperfusion, favorable functional outcome, first-attempt successful reperfusion, and mortality did not differ between patients treated with and without IVT.

Conclusions

We found no significant differences in clinical, technical and safety outcomes between patients with a large vessel occlusion in the posterior circulation treated with or without IVT prior to endovascular therapy. Our results are in line with the literature on the anterior circulation.
Predicting structures of large protein assemblies using combinatorial assembly algorithm and AlphaFold2
Authors: Shor Ben , Schneidman-Duhovny Dina
Published: May 2023

Deep learning models, such as AlphaFold2 and RosettaFold, enable high-accuracy protein structure prediction. However, large protein complexes are still challenging to predict due to their size and the complexity of interactions between multiple subunits. Here we present CombFold, a combinatorial and hierarchical assembly algorithm for predicting structures of large protein complexes utilizing pairwise interactions between subunits predicted by AlphaFold2. CombFold accurately predicted (TM-score > 0.7) 72% of the complexes among the Top-10 predictions in two datasets of 60 large, asymmetric assemblies. Moreover, the structural coverage of predicted complexes was 20% higher compared to corresponding PDB entries. We applied the method on complexes from Complex Portal with known stoichiometry but without known structure and obtained high-confidence predictions. CombFold supports the integration of distance restraints based on crosslinking mass spectrometry and fast enumeration of possible complex stoichiometries. CombFold’s high accuracy makes it a promising tool for expanding structural coverage beyond monomeric proteins.
Tool for automatic macrozone characterization from EBSD data sets of titanium alloys
Authors: Fernández Silva B. , Jackson M. , Fox K. , Wynne B. P.
Published: May 2023

Microtexture heterogeneities are commonly found in titanium forgings because of the thermomechanical processing. Also known as macrozones, these regions can reach millimetres in length, with grains sharing a similar crystallographic orientation leading to less resistance to crack propagation. Since the link between macrozones and the reduction of cold-dwell-fatigue performance on rotative components in gas turbine engines was established, efforts have been put into macrozone definition and characterization. The electron backscatter diffraction (EBSD) technique, widely used for texture analysis, allows for a qualitative macrozone characterization; however, further processing is required to define the boundaries and disorientation spread of each macrozone. Current approaches often use c-axis misorientation criteria, but this can sometimes lead to a large disorientation spread within a macrozone. This article describes the development and application of a computational tool implemented in MATLAB for automatic macrozone identification from EBSD data sets on the basis of a more conservative approach where both the c-axis tilting and rotation are considered. The tool allows for detection of macrozones according to the disorientation angle and density-fraction criteria. The clustering efficiency is validated by pole-figure plots, and the effects of the key parameters defining the macrozone clustering (disorientation and fraction) are discussed. In addition, this tool was successfully applied to both fully equiaxed and bimodal microstructures of titanium forgings.
Synthesis and crystal structure studies of 5-(trifluoromethyl)-1,3,4-thiadiazol-2(3H)-one at 180 K
Authors: Geetha Doreswamy , Mohan Kumar Thaluru M. , Anil Kumar Haleyur G. , Shreenivas Mellekatte T. , Basavaraju Yeriyur B. , Yathirajan Hemmige S. , Parkin Sean
Published: May 2023

The synthesis and crystal structure of C3HF3N2OS, systematic name 5-(trifluoromethyl)-1,3,4-thiadiazol-2(3H)-one (5-TMD-2-one), a compound containing the pharmacologically important heterocycle 1,3,4-thiadiazole, is presented. The asymmetric unit comprises six independent molecules (Z′ = 6), all of which are planar. The r.m.s. deviations from each mean plane range from 0.0063 to 0.0381 Å, not including the CF3 fluorine atoms. Within the crystal, two of the molecules form hydrogen-bonded dimers that in turn combine with inversion-related copies to form tetrameric constructs. Similar tetramers, but lacking inversion symmetry, are formed by the remaining four molecules. The tetramers are linked into tape-like motifs by S...O and O...O close contacts. The environments of each symmetry-independent molecule were compared via a Hirshfeld surface analysis. The most abundant atom–atom contacts are between fluorine atoms, while the strongest result from N—H...O hydrogen bonds.
2-[3-(1H-Benzimidazol-2-yl)propyl]-1H-benzimidazol-3-ium 3,4,5-trihydroxybenzoate–1,3-bis(1H-benzimidazol-2-yl)propane–ethyl acetate (2/1/2.94): co-crystallization between a salt, a neutral molecule and a solvent
Authors: Palacios Rodríguez José Carlos , Mendoza Angel , Sosa Rivadeneyra Martha , Bernès Sylvain
Published: May 2023

The chemical formula of the title compound, 2C17H17N4
+·2C7H5O5
−·C17H16N4·2.94C4H8O2, was established by X-ray diffraction of a single-crystal obtained by reacting 1,3-bis(benzimidazol-2-yl)propane (L) and gallic acid (HGal) in ethyl acetate. The molecular structure can be described as a salt (HL)+(Gal)− co-crystallized with a molecule L, with a stoichiometric relation of 2:1. Moreover, large voids in the crystal are filled with ethyl acetate, the amount of which was estimated by using a solvent mask during structure refinement, affording the chemical formula (HL
+·Gal−)2·L·(C4H8O2)2.94. The arrangement of components in the crystal is driven by O—H...O, N—H...O and O—H...N hydrogen bonds rather than by π–π or C—H...π interactions. In the crystal, molecules and ions shape the boundary of cylindrical tunnels parallel to [100] via R (rings) and D (discrete) supramolecular motifs. These voids, which account for about 28% of the unit-cell volume, contain disordered solvent molecules.
The performance of major airports in the Europe, North America and Asia
Authors: Park Jae-Woo , Roh Saeyeon , Jang Hyunmi , Seo Young-Joon
Published: May 2023

Purpose

This study aims to provide a meaningful comparison of airports’ performance and better understand the differences observed in the analysed airport performance by presenting a model to analyse the relationship between operational and financial performance and airport characteristics.

Design/methodology/approach

This study uses a quantitative analysis approach. The Technique for Order Preference by Similarity to Ideal Solution (TOPSIS) and entropy weight were utilised to analyse 17 airports in three Airports Council International regions: Asia, Europe and North America. Through operational and financial factors, these sample airports identified the most efficiently operated airports from 2016 to 2019.

Findings

Overall, Asian airports were superior in operational and financial efficiency. Unlike operating performance, the sample airport’s financial and total performance results show a similar trend. There were no noticeable changes in operational factors. Therefore, differences in financial variables for each airport may affect the total performance.

Practical implications

This study provides insightful implications for airport policymakers to establish a standardised information disclosure foundation for consistent analysis and encourage airports to provide this information.

Originality/value

The adoption of Earnings Before Interest, Taxes, Depreciation, and Amortisation (EBITDA) to debt ratio and EBITDA per passenger, which had previously been underutilised in the previous study as financial factors, demonstrated differences between airports for airport stakeholders. In addition, the study presented a model that facilitates producing more intuitive results using TOPSIS, which was relatively underutilised compared to other methodologies such as date envelopment analysis.
Unpacking the strategies to promote the implementation of automation techniques in the construction industry
Authors: Oke Ayodeji Emmanuel , Aliu John , Fadamiro Patricia , Akanni Prince , Jamir Singh Paramjit Singh , Shaharudin Samsurijan Mohamad
Published: May 2023

Purpose

This study aims to identify and evaluate the key strategies to promote the implementation of automation techniques with reference to the Nigerian construction industry.

Design/methodology/approach

Pragmatic philosophical thinking using a mixed-method approach (a combination of qualitative and quantitative) was adopted for this study. The qualitative strand of this research was achieved using a Delphi technique while a well-structured questionnaire conducted among 191 construction professionals was adopted to attain the quantitative strand. Obtained data were analyzed using frequencies, percentages, mean item scores, Kruskal–Wallis H test and exploratory factor analysis (FA).

Findings

Results revealed that the “provision of funding and subsidies for automation techniques” “mandatory automation policies and regulations,” “creating incentives for adoption,” “formulation of programs to promote awareness” and “deploying gamification to boost employee performance” were the top five strategies to promote the adoption of automation techniques. FA revealed four principal clusters, namely, awareness and publicity programs, government regulations and standards, provision of education and training and awards and recognition.

Practical implications

This study provided a solid theoretical and empirical foundation that can be useful to construction industry stakeholders, decision-makers, policymakers and the government in mapping out strategies to promote the incorporation and deployment of automation and robotics in the construction industry.

Originality/value

To the best of the authors’ knowledge, this study is one of the first in developing countries and Nigeria to establish an ordered grouping structure of the strategies to promote the adoption of automation techniques.
Investigating the performance of European banks using non-parametric techniques: the role of performing loans efficiency
Authors: Dimitras Augustinos I. , Dokas Ioannis , Mamou Olga , Spyromitros Eleftherios
Published: May 2023

Purpose

The scope of this research is to investigate performing loan efficiency for fifty European banks during the period 2008–2017.

Design/methodology/approach

The study is structured as a two-stage analysis of performing loan efficiency and its driving factors. In the first stage of the proposed methodology “Data Envelopment Analysis” is used to estimate performing loan efficiency for each bank included in the sample. A bootstrap statistical procedure enhances the findings. In the second stage, the impact of other factors on the efficiency scores of loan performance using tobit regression is investigated.

Findings

The results are consistent with the findings of the individual banks' financial analyses. According to the findings of DEA implementation, the evaluated banks may enhance their cost efficiency by 39% on average. In addition, the results indicate that loan efficiency performance improves after 2015, coinciding with the business cycle's upward trend. The tobit regression is employed in the second stage to examine the influence of bank-related and macroeconomic factors on banks' loan management efficiency. According to the findings of the tobit regression, three factors, namely the capital adequacy ratio, GDP per capita and managerial inefficiency, have a substantial influence on performing loan efficiency.

Originality/value

This research investigates the effectiveness of European economic policy in protecting the European banking system from the consequences of the sovereign debt crisis in several euro area members. The results highlight the distance of the Eurozone from the level of the ‘optimal currency area’.
Conducting responsible research in hospitality management with greater societal impact
Authors: Pereira-Moliner Jorge , Molina-Azorín José F.
Published: May 2023

Purpose

This study aims to highlight the importance of developing academic research in tourism and hospitality management into a more responsible approach, applying a multistakeholder model. This multistakeholder approach forces the tourist community to be considered when identifying the gaps and impacts of academic research.

Design/methodology/approach

This study suggests action research as one of the appropriate methodological approaches for conducting responsible research, as action research allows challenges to be overcome through the interaction of researchers and stakeholders. Principles of responsible research are indicated and exemplar studies that use action research are described.

Findings

Proposals and recommendations for responsible research are identified, such as demand-driven research, action research as a methodological approach and a way to address societal challenges, and the importance of considering the research ecosystem. In addition, some advantages (funding, reputation and legitimacy) and barriers (resources and publication) of responsible research are explained.

Practical implications

Practical implications are described. Conducting responsible research is oriented toward identifying real practical implications proposed and validated by the tourist community instead of being proposed solely by the researchers.

Social implications

This paper emphasizes the need to work together with the tourist community and their stakeholders to enhance the real societal impact of academic research in tourism and hospitality management.

Originality/value

The authors would like to raise a self-critical debate for the future enrichment of research in the tourism industry. Research in this industry can contribute to solving significant societal problems. Responsible research can help scholars to be part of the solution to these challenges, working together with different tourism stakeholders.
The effect of proximal personality traits on entrepreneurial intention among higher education students
Authors: Brás Gonçalo Rodrigues , Daniel Ana , Fernandes Cristina
Published: May 2023

Purpose

According to the literature, general personality traits are less strongly related to the creation of new ventures than specific/proximal personality traits. Therefore, this study aims to understand the different proximal personalities that influence the entrepreneurial intention to start a new venture and the relationship between them.

Design/methodology/approach

Data were gathered through a self-administered questionnaire filled in by students of entrepreneurship or related courses at the end of the second semester (2019/2020 academic year), and the research option is based on covariance-based structural equation modelling.

Findings

The results of this study show that entrepreneurial intentions can be predicted by specific individual traits, namely, risk-taking, entrepreneurial alertness, creativity, proactivity and self-efficacy. Moreover, it was found that risk-taking mediates the relationship between entrepreneurial alertness and proactivity. On the other hand, students’ creativity mediates the relationship between risk-taking and proactivity. Finally, students’ self-efficacy mediates the relationship between proactiveness and entrepreneurial intention.

Practical implications

The results have implications for entrepreneurship education given that a better understanding of the personality traits that influence entrepreneurial intentions can lead to the development of new approaches and pedagogical tools.

Originality/value

This model can be used as a diagnostic tool for designing an effective and efficient entrepreneurship curriculum and pedagogy, acting as an (ongoing) audit of students’ entrepreneurial intentions to get a scientific basis in case of further course/module adjustments.
Application of Six Sigma methodology using DMAIC approach for a packaging olives production system: a case study
Authors: Tsarouhas Panagiotis , Sidiropoulou Niki
Published: May 2023

Purpose

In a packaging olives manufacturing system, the drained weight of the product plays a decisive role in customer’s satisfaction as well as in financial saving for the organization. The purpose of this study is to minimize the variation of the drained weight of olives in the production system to avoid the negative consequences.

Design/methodology/approach

The research develops a practical implementation step-by-step of Six Sigma define, measure, analyze, improve and control (DMAIC) in reducing the variation of the drained weight of olives.

Findings

Data analysis was used at various phases of the project to identify the root causes of rejection and rework. As a result of the necessary interventions and actions to optimize the manufacturing process, the standard deviation of drained weight was significantly reduced by 51.02%, with a 99.97% decrease in the number of parts per million defectives. Thus, the yield of the production process was improved by 8.24%. The estimated annual savings from this project were US$ 228,000 resulting from reduced rejection and rework.

Practical implications

This research may be used in packaging olives production systems as a tool for managers and engineers planning to increase productivity and efficiency while also improving product quality. The study also provided the organization with helpful actions that will be used to guide future Six Sigma operations management on the system. Thus, practical guidelines and solutions are provided.

Originality/value

In this project, for the first time, the Six Sigma methodology has been applied to solve a real-world problem in the packaging olives manufacturing system and to show that the DMAIC approach may assist to improve the efficiency of their operations and hence contribute to their quest toward continuous improvement.
Career plateau and counterproductive work behaviour: a moderated moderation model of abusive supervision and job embeddedness
Authors: Jain Vivek , Chhabra Bindu
Published: May 2023

Purpose

Drawing upon the social identity theory (SIT), the present study aims to examine the moderating role of abusive supervision (AS) and job embeddedness (JE) in the relationship between career plateau (CP) and counterproductive work behaviour (CWB). The research also aims to investigate whether JE moderated the moderating effect of AS on the CP–CWB relationship.

Design/methodology/approach

The hypotheses were tested with two-wave survey data collected from 290 employees working in India’s banking, financial services and insurance sector. Data were analysed using moderation and moderated moderation analyses on PROCESS v 4.1 macro.

Findings

Results showed that AS moderated the CP–CWB relationship, whereas the moderating role of JE was not observed. However, JE was seen to moderate the moderating effect of AS, supporting the moderated moderation framework.

Research limitations/implications

The present study adds value to the existing literature by connecting SIT with hierarchical layers. The supervisor themselves may stay longer in their current positions and block the subordinates’ progress. This impacts the social image of the subordinates. The study enriches the CP literature by highlighting that CP may lead to CWB, as the employees who perceive CP hit back at the organisation for being unfairly treated and not getting the career progression due to their supervisor.

Practical implications

The study provides important implications for the supervisors who need to introspect if their behaviour is viewed as abusive by the career-plateaued employees. They need to mentor the employees, especially those with higher career aspirations, and provide them with various career avenues. Furthermore, organisations should make all possible efforts to embed the employees within their jobs as the embedded employees can better take the shock of CP.

Originality/value

Drawing on the SIT, the study contributes uniquely to the employee behaviour literature by investigating the impact of CP, AS and JE on CWB in hierarchically flatter organisations. This is the first study to investigate the moderated moderation model of AS and JE in the CP–CWB relationship in the context of employees’ social status within the organisation.
Using community-based social marketing to identify promising behavioral targets for reducing greenhouse gas emissions among college students
Authors: Ross Elizabeth C. , Aloise-Young Patricia A. , Curcio Hannah
Published: May 2023

Purpose

The purpose of this paper is to recommend behavioral targets for future interventions to reduce greenhouse gas emissions at college campuses and to advise interventionists on how to choose between many potential behavioral targets.

Design/methodology/approach

The authors used the community-based social marketing (CBSM) methodology over two studies. In Study 1, the authors assessed adoption rates (i.e. penetration) and likelihood of adoption (i.e. probability) for 16 potential behavioral targets. In Study 2, the authors used quantitative and qualitative methods to assess the barriers and benefits of engagement in five of the top-performing behaviors from Study 1.

Findings

The findings suggest that an intervention to promote purchasing green energy credits (GECs) has a high potential to reduce emissions. Purchasing GECs has a small penetration (<7%) and a large impact (1,405 kgCO2e/person/year). Compared to the other four behaviors the authors examined in Study 2, purchasing GECs is also more convenient and requires very little time. Thus, the behavior should be appealing to many individuals interested in reducing emissions or protecting the environment.

Originality/value

The authors performed a holistic evaluation of potential behavioral targets that included a barrier and benefit analysis, in addition to the traditional CBSM method of combining impact, probability and penetration.
Tacit knowledge sharing in information systems development projects: social interdependence and regulatory focus perspectives
Authors: Hung Shin-Yuan , Tsai Jacob Chia-An , Chen Kuanchin , Chen Charlie , Yeh Ting-Ting
Published: May 2023

Purpose

The purpose of this study is to examine tacit knowledge sharing within information systems development (ISD) projects by exploring the combination of social interdependence theory and regulatory focus theory (RFT).

Design/methodology/approach

A survey was conducted on 198 ISD professionals to investigate the effect of social interdependence on tacit knowledge sharing. The survey data were analyzed using partial least squares structural equation modeling (PLS-SEM), and the results were discussed.

Findings

This study reveals that team members tend to share tacit knowledge in a way characterized by cooperative interdependence, and different patterns of social interdependence have an impact on tacit knowledge sharing. The RFT explains the disparities in attitude toward tacit knowledge sharing. Specifically, individuals with a prevention-focused orientation positively moderate the impact of competitive interdependence on tacit knowledge sharing, while those with a promotion-focused orientation have a negative moderating effect on the effect of competitive interdependence on tacit knowledge sharing. Moreover, promotion-focused individuals negatively moderate the effect of cooperative interdependence on tacit knowledge sharing.

Originality/value

The study identifies important aspects of social interdependence in ISD projects that affect the management of tacit knowledge. Furthermore, the study shows that the influence of cooperative and competitive interdependence on tacit knowledge sharing is moderated by the regulatory focus of an individual, providing new insights into ISD knowledge management.
Credibility of Youtube product reviews and customers' product return intention: a product fit uncertainty perspective
Authors: Nugroho Aditya , Wang Wei-Tsong
Published: May 2023

Purpose

This research aims to examine the factors that influence customers' product return intentions and proposes that YouTube product reviews can mitigate customers' desire to return a product.

Design/methodology/approach

The proposed theoretical research model and hypothesized relationship were investigated using a quantitative process. This study used 302 data from Indonesian young adult respondents to examine the structural model, which was analyzed using the SmartPLS 3.2 software package.

Findings

The results show that YouTube product reviews, product fit uncertainty and customer satisfaction are the key determinants of customers' product return intention. Furthermore, the results show that the credibility of YouTube product reviews has a major impact on customers' familiarity with a product, satisfaction and the likelihood of returning goods to sellers.

Practical implications

In the e-commerce industry, increasing the use of YouTube product reviews will help businesses eliminate unnecessary product returns. Sellers are also encouraged to collaborate with YouTube producers to review specific products, which can benefit companies by raising brand awareness and gaining customer feedback. Furthermore, YouTube online product reviews can help consumers avoid having an unpleasant shopping experience that causes emotional reactions and lowers satisfaction.

Originality/value

Most research has not considered antecedents in observing the product return phenomenon; this study observes a prerequisite of consumer product returns (i.e. information asymmetry and product familiarity) and investigates the relationships between YouTube product reviews, customer satisfaction and product return intention.
Theorising the dark side of interorganizational relationships: an extension
Authors: Pillai Kishore Gopalakrishna , Sharma Piyush , Cornelissen Joep , Zhang Yumeng , Nair Smitha R.
Published: May 2023

Purpose

This paper aims to propose mechanisms of the dark side of interorganizational relationships from a social psychological perspective. The purpose is to understand the role of boundary spanners’ social psychological processes that may trigger the dark side effects.

Design/methodology/approach

Multple mechanisms are developed through three social psychological theories, namely, social identity theory, system justification theory and social learning theory.

Findings

Boundary spanners’ social psychological processes can trigger the dark side of interorganizational relationships via mechanisms such as excessive cooperation, reification, system justification and path dependence in learning.

Practical implications

This paper concludes with a discussion that offers a new perspective on research on dark side effects and the managerial implications of the present analysis.

Originality/value

This paper contributes to the current literature by extending the interpersonal social psychological processes that could explain the dark side of interorganizational relationships. This paper is a step forward to answer the calls for multilevel considerations of the dark side effects and inspire future research on the role of social psychological processes in dark side effects.
Bank risk and returns: did prompt corrective action make a difference?
Authors: Ghosh Saibal
Published: May 2023

Purpose

The purpose of this paper is to assess the effects of prompt corrective action on bank risk and returns in an empirical framework.

Design/methodology/approach

The paper uses a difference-in-difference specification to analyse whether and how PCA affects bank risk and returns. As part of robustness, the analysis also uses a fixed effects specification with Driscoll–Kraay standard errors to account for serial correlation and cross-sectional dependence.

Findings

The findings reveal that banks under PCA framework contribute less to systemic risk and exhibit higher market valuation. These findings differ across recapitalised versus non-recapitalised banks and for banks with differing asset quality, capital and profitability. The overall price impact is a decline in lending rates and deposit costs.

Originality/value

To the best of the author’s understanding, this is one of the early studies in the Indian context to carefully examine the linkage between PCA and bank behaviour.
Internal auditors’ independence under workplace bullying stress: an investigative study
Authors: Taha Alaa A.D.
Published: May 2023

Purpose

This study aims to examine the direct influence of workplace bullying (WB) on internal auditors’ independence using the nexus between the agency theory and social exchange theory. From the internal auditors’ perspective, the investigation covered both government and private colleges and universities in one of the Middle East countries.

Design/methodology/approach

A survey was administered and delivered to internal auditors at each of the 85 educational institutions. A total of 267 valid questionnaires were analysed. The study’s measurement and structural models were tested and evaluated by using SmartPLS v.4 and partial least squares-structural equation modelling.

Findings

The study results indicated that bullying is common among senior managers, and that it has a significant, negative, high-level and direct effect on the independence of internal auditors in the higher education sector.

Practical implications

Regulators and other stakeholders should make a deliberate effort to promote positive behaviours and abandon negative ones regarding the independence of internal auditors and the performance of audit teams, which play a crucial role in enhancing the efficiency of audit units. For example, enhancing coordination and communication internally and externally. In addition to providing the internal auditors with equitable advancement and learning opportunities, senior management should also support their professional development.

Originality/value

To the best of the author’s knowledge, this study is the first to examine the relationship between WB and the internal auditor’s independence in the context of government and private organisations in Southwest Asian countries.
Credibility and trust of information privacy at the workplace in Slovakia. The use of intuition
Authors: Svenson Frithiof , Ballová Mikušková Eva , Launer Markus A.
Published: May 2023

Purpose

Employees may feel overwhelmed with information privacy choices and have difficulties understanding what they are committing to in the digital workplace. This paper aims to analyze the role of different thinking styles for effort reduction, such as the use of intuition, when employees make decisions about the credibility and trustworthiness of workplace information privacy issues in Slovakia. While the General Data Protection Regulation sets precise requirements for valid consent, organizations are classified as data controllers and are subject to credibility judgments by their employees.

Design/methodology/approach

Data was collected from 230 employees in Slovakia using a survey questionnaire. Quantitative analysis using SPSS was conducted to describe employees thinking preferences when judging the credibility of information privacy in their organizations.

Findings

The survey participants revealed their perceived credibility and trust in personal data protection and thinking preferences. Unconscious thinking is the type of effort reduction often reported by participants, who perceive high credibility and trust in personal data protection. This study can help managers and data controllers in small- and medium-sized enterprises in reflecting about the way in which people use different thinking processes for decision-making about information privacy in their organizations.

Research limitations/implications

This study set out to explore how decision-making processes at the workplace relate to credibility of data practices. Focusing on the use of different types of intuition, the authors explored whether the preference for a specific decision-making style can explain the perceived credibility of data practices. The part of the workforce in the sample did not have a strict predisposition to use either intuitive or rational thinking.

Practical implications

The contribution provides scholars with an overview of the field of intuition, a field that is likely to grow given the challenges of digitalization for organizations, such as shitstorms, cyberattacks and whistleblowing.

Originality/value

The most well-known concepts from intuition research, e.g. the dual process theory, and practice are tested simultaneously, therewith contributing to the applied literature on domain-specific preferences for intuition and deliberation in decision-making.
Factors affecting the citizen’s intention to adopt e-government in Nigeria
Authors: Muhammad Abubakar Sadiq , Kaya Tuğberk
Published: May 2023

Purpose

This study aims to investigate and comprehend the key factors that affect citizens’ adoption of electronic government (e-government) in Nigeria. In addition, the exploration intends to assess the potential determinants that may affect the Nigerian’s behavioural intention (BI) to adopt e-government services. The findings can be helpful for policymakers and government officials to provide e-government practices effectively.

Design/methodology/approach

The research adopted a quantitative method using the unified model of e-government adoption (UMEGA). In this study, data are collected from 410 citizens aged above 18 years old and analysed using partial least squares path modelling technique.

Findings

The results showed that performance expectancy and effort expectancy positively influenced attitude (ATT) towards e-government. In contrast, perceived risk negatively impacted ATT towards e-government. However, social influence did not have a significant influence. The results showed that ATT and facilitating conditions (FC) positively influenced the BI to use e-government services. The explanatory and predictive power of UMEGA in Nigeria accounted for 63.9%.

Originality/value

To the authors’ knowledge, no prior studies analysed citizens’ adoption of e-government in Nigeria. This study, however, filled this gap. This study has contributed to the current knowledge of e-government adoption in Nigeria, which policymakers and government officials can use.
TMT entrepreneurial passion diversity and firm innovation performance: the mediating role of knowledge creation
Authors: Chen Jiawen , Liu Linlin
Published: May 2023

Purpose

This study extends the literature on top management team (TMT) diversity and innovation by introducing entrepreneurial passion diversity as an important TMT affective component in determining firm innovation performance. This paper draws on the knowledge-based view and proposes that TMT passion diversity, in terms of intensity separation and focus variety, may hinder the process of knowledge creation, and, in turn, reduce firm innovation performance.

Design/methodology/approach

The authors conduct a questionnaire survey using a simple random sampling technique and collect data from 195 small- and medium-sized enterprises in China. Ordinary least squares regression and a structural equation model are applied to test the hypotheses.

Findings

This study finds that TMT passion intensity separation has a negative effect on firm innovation performance via knowledge exchange and knowledge combination. TMT passion focus variety has a negative effect on firm innovation performance via knowledge combination.

Originality/value

This study highlights the affective diversity of entrepreneurial passion in TMTs and clarifies the detrimental role of TMT entrepreneurial passion diversity in innovation and knowledge creation. It contributes new insights to the literature on TMT diversity, knowledge management and entrepreneurial passion.
“Improved access, delayed accreditation, low recognition”: perspectives of mental health educators, preceptors and students on the Kintampo Project in Ghana
Authors: Agyekum Mary Pomaa , Odopey Selase Adjoa , Asiamah Sabina , Wallis Lucy , Williams John E.O. , Locke Rachel
Published: May 2023

Purpose

The purpose of this study explores the perspective of key informants (educators, preceptors and former students) of the Kintampo Project, on the perceived effectiveness, gains and challenges in delivering this large-scale training innovation in Ghana. The problem of mental health care neglect in Ghana is gradually improving. The Kintampo Project which trained mental health workers in Ghana has played a critical role in increasing access to mental health care.

Design/methodology/approach

This qualitative study explored participants' perspectives on the Kintampo Project in three broad areas: perceived effectiveness, gains and challenges. In all, 17 interviews were conducted with former students, preceptors and educators from the project. The interviews were digitally audio-recorded, transcribed, coded and analysed using deductive and thematic methods.

Findings

The participants perceived the project to have been successful in increasing the number of mental health workers in Ghana. The project provided a route for career progression for those involved. However, the Kintampo Project faced accreditation issues, low recognition, improper integration and remuneration of trained staff in the Ghana Health Service. This study points to the fact that the sustainability of mental health training in Ghana can be obstructed, because of this career path being less attractive. Further research is needed to explore how best to achieve sustainability of similar mental health innovations.

Originality/value

This paper shares the views of participants in the Kintampo Project.
Comparing the attitudes of junior doctors towards mental and physical ill-health: a survey of trainees in North London
Authors: Levene Tamara , Stock Lisanne
Published: May 2023

Purpose

Doctors are more likely to suffer from mental illness in comparison to the wider population. This is particularly true for junior doctors, who are at increased risk in comparison to their senior colleagues. This study aims to identify whether junior doctors in North London are comfortable discussing mental health problems with their peers and supervisors and to compare how comfortable they are discussing mental and physical health problems.

Design/methodology/approach

An anonymous online questionnaire was designed with demographic data, multiple-choice questions and free-text boxes. This was distributed via email to core psychiatry trainees and foundation doctors in North London. Drug- and alcohol-related disorders were excluded from our definition of mental illness in this survey, as these are reportable to the General Medical Council.

Findings

A total of 51 junior doctors responded to the survey. The respondents were significantly more likely to discuss mental health problems with their peers in comparison to their supervisors. They were also less likely to discuss mental health problems in comparison to physical health problems with their peers, supervisors or general practitioner. Qualitative analysis of the free-text comments elucidated several themes including the stigmatisation of mental health.

Originality/value

To the best of the authors’ knowledge, there has been no prior research in the UK comparing the attitudes of junior doctors towards physical and mental ill-health. The questionnaire highlights the continued stigma towards mental health within the medical profession. The difference in attitudes towards physical and mental ill-health has important implications for the training and well-being of junior doctors.
Exploration of potential money laundering crimes with virtual currency facilities in Indonesia
Authors: Meiryani Meiryani
Published: May 2023

Purpose

The purpose of this study is to exploration potential money laundering crimes with virtual currency facilities in Indonesia. Money laundering using crypto is the process of disguising the origin of money obtained illegally. Then, the perpetrator transfers it to a legitimate business. Virtual money then started to become a phenomenon in society since the emergence of cryptocurrencies as a form of technology development of e-commerce activities.

Design/methodology/approach

This research method is normative law which is prescriptive. The data collection technique used is document study or literature study by collecting primary and secondary legal materials.

Findings

The results of this study show that the bitcoin virtual currency has the potential to act as a means of money laundering. There are technologies and online platforms that are moving with more sophisticated methods. Through bitcoin exchanges, it has the greatest potential for money laundering. The usage of virtual currency (cryptocurrency) by those who commit money laundering offenses is responsible for the actions’ severe negative effects on the State of Indonesia.

Originality/value

To the best of the author’s knowledge, this is the first study conducted in Indonesia that explores potential money-laundering crimes using virtual currency facilities.