bluuebunny/crossref_metadata_2025 huggingface dataset:
Targeted protein degraders: Blood–brain barrier permeability and central nervous system exposure
Authors: Singh Satinder , Kumar Satish , M. Shingatgeri Vyas , Srivastava Pratima
Published: February 2025

Innovative approaches are essential for treating central nervous system (CNS) diseases that present severe neurological manifestations and low survival rates. Delivering chemical or biological molecules across the blood–brain barrier (BBB) at therapeutically effective concentrations to treat CNS pathologies is a significant challenge. The urgent need for novel treatments targeting disease-causing proteins has propelled targeted protein degraders (TPDs) into the spotlight. TPDs have emerged as promising therapeutics for the treatment of CNS proteinopathies, characterized by the accumulation of misfolded protein aggregates. Given their structural features, the BBB permeability and CNS bioavailability of TPDs may seem improbable. However, several TPDs have demonstrated measurable concentrations in cerebrospinal fluid and the brain. Understanding the mechanisms behind their permeability across the BBB could open new avenues for the development of more effective TPD-based therapies for CNS proteinopathies. This review explores the absorption, distribution, metabolism, and excretion properties of TPDs in relation to brain pharmacokinetic parameters. It also delves into the likely interactions of advanced-stage TPDs with drug transporters and possibilities of disruption-propelled versus B-B barrier permeability-driven CNS bioavailability. Finally, it provides critical insights into the BBB permeability aspects of TPDs, uncovering new dimensions for future research.
Physicochemical properties of gelatin/hyaluronic acid printed hydrogel and incorporated with thymoquinone: In Vitro evaluation of biocompatibility for wound healing
Authors: Md Fadilah Nur Izzah , Tabata Yasuhiko , Maarof Manira , Fauzi Mh Busra
Published: February 2025

Wound healing is a multifaceted biological process that necessitates the development of advanced materials that can effectively support tissue regeneration and repair. The fabrication of bioengineered wound dressings has evolved significantly, with three-dimensional (3D) bioprinting emerging as a promising method to produce personalized, structurally stable hydrogels. In this study, we leveraged extrusion-based 3D bioprinting technology to develop gelatin-hyaluronic acid (GEL-HA) hydrogels, incorporating thymoquinone (TQ), a bioactive compound known for its regenerative properties. The use of 3D printing allowed for precise control over the scaffold’s architecture, optimizing its compressive strength and resilience while creating a bioactive, biocompatible platform for wound healing applications. This enabling precise control over their architecture and mechanical properties to enhance wound healing where it offers promising potential as biocompatible scaffolds for wound healing applications due to their favorable physicochemical properties and ability to promote cell proliferation and migration. GEL-HA hydrogels were fabricated with varying hyaluronic acid (HA) concentrations (0.1-1.0 wt%), and the effects on the gelation process and physical characteristics were evaluated.  Results showed that the ideal gelation temperature for the GEL-HA hydrogel was 22°C, with the inclusion of HA reducing polymerization time. The printed hydrogels exhibited high water retention (>1000%) and satisfactory mechanical properties, with a degree of crosslinking of up to 40.21%. Furthermore, the hydrogels demonstrated a low biodegradation rate (less than 0.300 mg/h) and favorable water vapor transmission rates (WVTR) in a range of 2000-3000 gm-2day-1, which are crucial for maintaining a moist environment in wound healing. The incorporation of TQ further enhanced the biocompatibility and cellular proliferation of human dermal fibroblasts (HDFs). Cell viability assays indicated that TQ promoted HDF growth at concentrations of 0.005–0.1 μg/mL without toxicity. Moreover, the wound scratch assay demonstrated that TQ facilitated cell migration, with the optimum concentration of 0.1 μg/mL showing the most significant effect. The GEL-HA-TQ hydrogel also supported HDF attachment and proliferation, as confirmed by live and dead cell staining, also with Ki-67, and collagen type-I immunocytochemistry. These findings suggest that GEL-HA hydrogels, combined with TQ, provide a promising and biocompatible platform for wound healing. It effectively promotes cell viability, migration, and extracellular matrix synthesis, which could be beneficial in regenerative medicine and tissue engineering applications.
Northern Harding Icefield glacier mass balance summary: 2010?2017
Authors: Kurtz Deb , Kurtz Deb
Published: February 2025

Glaciers cover nearly half of Kenai Fjords National Park, serving an important role in ecosystem dynamics and attracting hundreds of thousands of visitors to the park each year. Glacial melt is important to park managers as it impacts visitor experience, infrastructure (e.g., trails and roads), and downstream habitats. Glacier mass balance is the annual gain and loss of ice calculated as a sum of seasonal measurements of accumulation and ablation (the loss of ice through melt, sublimation, and calving). Long-term glacier mass balance studies provide an established method for monitoring the status of glaciers and can be used to estimate rates of change and to predict thresholds and trigger points that could result in major changes to glacier extent and downstream systems.
This report summarizes field efforts and results of eight years of stake-based mass balance measurements on the northern Harding Icefield, for water years 2010?2017. From 2010?2017, seasonal measurements were conducted at six sites on the northern Harding Icefield to quantify seasonal and annual point mass balances along an elevation gradient from 532 m to 1290 m. Cumulative winter mass balances range from 0.47 to 1.81 meters water equivalent (m w.e.) at the lowest site (532 m a.s.l), and 2.11 m w.e. to 3.43 m w.e. at the highest site with continuous annual data (1230 m a.s.l). Summer mass balances range from ?5.85 m w.e. to ?8.35 m w.e. at the lowest site (532 m a.s.l.) and ?0.54 to ?2.24 at the site located at 1230 m a.s.l.. Although all sites display interannual variability in the seasonal and annual mass balance, the general trend is of decreasing mass balance. The two sites at the lowest elevations are in the ablation zone and display persistent negative mass balances. The two sites at the middle elevations have been oscillating around a zero or neutral balance and are near the Equilibrium Line Altitude (ELA). The two sites at the highest elevations have positive balances (mass gain) but have shown a decrease over the period of measurements. This has resulted in significant surface melt and elevation loss at lower elevations of Exit Glacier over the period of record.
Intubation difficile en réanimation
Authors: MONET Clément , CAPDEVILA Mathieu , LAKBAR Ines , CUNY Ambre , RAIMBERT Chloé , BRIANE Chloé , JABER Samir , DE JONG Audrey
Published: February 2025

L'intubation difficile et compliquée sont deux concepts différents qui ont tendance à se confondre. L'intubation trachéale en réanimation est difficile dans 8 à 20% des cas et s’accompagne d’une complication sévère dans 38 à 45% des cas. La recherche systématique des facteurs de risque d’intubation difficile et de complications est cruciale. Le MACOCHA score aide à identifier les patients à risque d’intubation difficile. L’endoscopie transnasale ou la vidéolaryngoscopie pré induction sont des outils supplémentaires pour évaluer ce risque. Pour prévenir l’intubation difficile, l’utilisation d’un protocole est absolument primordiale. Ce protocole devra reprendre tous les points importants de la préparation pré induction et inclure une stratégie en cas d’intubation difficile prévue et non prévue. En cas d’intubation difficile non prévue, l’enjeu sera à la ventilation possible ou non qui sera au cœur de la stratégie de contrôle des voies aériennes.
The oil issue in the context of the Anglo-Russian economic rivalry in Persia at the turn of the XIXXX centuries
Authors:   North-Caucasus Federal University, Pantyukhina T. V.
Published: February 2025

Introduction. The relevance and novelty of the paper is determined by the absence in the Russian historic literature of a special study of such an important aspect of the AngloRussian economic rivalry in Persia as the oil issue.
Materials and Methods. The main body of sources consisted of published documents of the Russian and British Foreign Ministries, agreements on Persian concessions, speeches and memoirs of British politicians and diplomats. The following methods were used: case study, the narrative, descriptive and comparative ones.
Analysis. At the height of the economic rivalry between Britain and Russia in Persia, the oil issue arose. The interest shown in it by each side sprang from different causes. Britain’s interest was driven by the Persian oil deposits, while Russia showed interest in Persian oil market. By the end of the XIX century Russian oil products had acquired a dominant position in the Persian market. Also, Baku oil producers were interested in Persia as the country through which the closest land routes to other markets in Asia and the Far East ran. Unlike Russians, British businessmen were seeking concessions related to oilfields exploitation. Despite the difference of interests, an oil issue was the source of tension, which rose to its peak in the diplomatic fight around D’Arcy Concession of 1901. Both Russian and British governments provided official and unofficial support to oil producers and traders in Persia. For the British government the oil issue was more specific: the possibility of obtaining a source of secure supplies of fuel oil for the British fleet.
Results. The policy of the British Government to back the Anglo-Persian Oil Company (APOC) proved to be justified as the oil factor became crucial in World War I. Largely due to Persian oil the British fleet had a certain advantage over the fleets of other powers during the war. As for the Anglo-Russian oil rivalry in Persia itself, the start of the exploitation of the oilfields by APOC affected the economic interests of Russia in the Middle East and Asia. Russian kerosene was forced out of the ports of the Persian Gulf. However, in Persia itself, Russian kerosene maintained a monopoly position until the end of the 1920s.
Stages of the licensing procedure in the field of higher education
Authors:   Saratov State Law Academy, Krasnoshchekov A. A.
Published: February 2025

Introduction. The article examines the features of the structure of the administrative licensing procedure in the field of higher education by studying its elements, namely the stages.
Materials and Methods. The use of the analysis method provided disclosure of the structure of the administrative licensing procedure in the field of higher education. The work also used a formal legal method, which made it possible to identify the essential features of the licensing stage in the field of higher education and formulate its definition.
Analysis. The stages of the administrative procedure for licensing educational activities in the field of higher education are primarily characterized by the presence of common features of the stages of administrative procedures. However, in science there are different points of view regarding the composition of the stages of the procedure under consideration.
Results. The stage of the procedure for licensing educational activities in the field of higher education should be treated as a relatively independent set of procedural actions performed within the time frame and in the sequence determined by regulations, in order to make a decision on the possibility of granting a license to carry out educational activities in the field of higher education, as well as for the implementation other normatively established goals determined by the need to license educational activities. The stages of licensing educational activities in the field of higher education include the following mandatory stages: the stage of initiating a licensing case; the stage of consideration of the licensing case and making a decision on it; the stage of providing the result of the state service for licensing educational activities. The optional stages of the administrative procedure under consideration include the stage of providing information about the license, as well as the stage of correcting typographical errors and (or) errors in the register of licenses and (or) in documents generated as a result of the provision of state licensing services.
The “Greens” of the “first hour” in the Federal Republic of Germany: social characteristics of the electorate
Authors:   Volgograd State Social and Pedagogical University, Evdokimova T. V.
Published: February 2025

Introduction. Currently, the increased interest in the German party “Union 90 / The Greens”, associated with its transformation from a “one-day butterfly” into a “green monster”, makes it relevant to turn to the origins of this party and raises the question of the legitimacy of comparing the early and modern “greens”
Materials and Methods. The fundamental principles of the research are the principles of historicism and authenticity, following which allows one to create a “portrait” of the “greens” at the stage of their organizational design and initial stage of development. Using historical-genetic and historical-comparative methods, the social component of the electorate of the Greens and their candidates is presented. The chronological scope of the article goes beyond the traditional consideration of the history of the party, from its creation in 1980, and extends to 1978. The source base of the research is the results of the elections to the Landtags of West Germany (1978), the European Parliament (1979), the Bundestag (1980, 1983), contained in the periodical press, and public opinion polls.
Analysis. The historical and sociological analysis of the above data allows us to state that the early “greens” mainly expressed the interests of the “new” middle strata of society (the intelligentsia, who worked as hired employees, the staff close to it, who held average leadership positions) and students. The voters of the Greens and the Greens themselves were distinguished by their relatively young age, high educational level and commitment to post-material values, which meant the need for freedom and creative self-realization. Advocating for the preservation of human life in conditions of environmental and nuclear danger, the “greens” have activated the most mobile part of society, ready for change.
Results. The Green Party became an indicator of the socio-economic, political and socio-cultural development of the FRG at the turn of the 1970s-1980s. The specific foreign policy situation in the world and the domestic political situation in the country predetermined the tasks and programmatic guidelines of the emerging party.
On the factors of transformation of modern international relations
Authors:   Moscow State Linguistic University, Kashirina T. V.
Published: February 2025

Introduction. The article analyzes the process of forming and transforming the Westphalian system of international relations. Special attention is paid to the transformation of its latest modification – the Yalta-Potsdam subsystem in the post-bipolar period. The author gives an assessment of the process of shaping the modern world order, especially after the deterioration of relations between the collective West and Russia in the context of a special military operation in Ukraine. The analysis of the factors of the fundamental restructuring of the modern world order is presented, the most significant of which are the conceptual revision of the foreign policy of Russia, strengthening ties with China and the countries of the Global South and the objective strengthening of non-Western countries in political and economic terms.
Materials and Methods. The research is based on the analysis of Russian and foreign historiography on the problem of the Westphalian system of international relations, official documents of the Russian Foreign Ministry and the US administration, Russian and foreign press. A systematic integrated approach, concrete historical and comparative historical methods were used.
Analysis. The Westphalian system of international relations developed cyclically. The periods of its development were interspersed with stages of a certain unipolarity and the subsequent desire for a collective solution to international issues. The decisive transformation of the Yalta-Potsdam subsystem was caused by the collapse of the USSR and the bipolar structure of the world. At the present stage, the trigger has become the strengthening of the foreign policy of Russia in the context of defending its national interests, especially in the post-Soviet space. The policy of the West to further expand NATO has become one of the reasons for the launch of a special military operation by Russia.
Results. The conclusion is made about the transformation of Westphal into the Yalta-Potsdam variation, but not about its complete breakdown. Radical restructuring is taking place under the influence of new factors of the world order - Russia, as a Eurasian state-civilization, is one of the centers of world development, actively defending its national interests; the role of China as a world power has significantly increased and the political and economic importance of the countries of the Global South is increasing.
The official activity of the undeservedly forgotten officer Nikolai Petrovich Beklemishev
Authors:   Pyatigorsk State University, Nikolaenko N. D. , Rutkovskaya M. V. ,   Pyatigorsk State University
Published: February 2025

Introduction. To preserve the historical memory of the exploits of our soldiers in defending the borders of Russia, remembering the traditions that existed in the army in the past, the authors analyze the official activities of the undeservedly forgotten officer of the Russian Imperial Army Nikolai P. Beklemishev. They consider in which military units he served, what positions he held, and what awards he was awarded.
Materials and Methods. The research is based on the analysis of various published documents and materials. The work uses the method of system analysis, which allowed the authors analyze the official activities of N.P. Beklemishev. Historical-systemic and narrative-descriptive methods helped the authors to consider the main milestones of his life.
Analysis. The authors analyze that one of the representatives of an ancient noble family devoted his life to serving the Motherland and protecting it. In the Caucasus, he participated in the Darginsky campaign of Count M.S. Vorontsov, and in the so-called “Sukhar expedition”, proved himself to be a brave, competent officer capable of organizing defense in difficult conditions of retreat. Then he served as commander of the 6th Brigade of the Caucasian Line Cossack Army (hereinafter referred to as the KLKV) and head of the center of the Caucasian Line. In the Orenburg province, while serving as commander of the Bashkir-Meshcheryak army, he defended the interests of the Bashkir people. He commanded various cavalry formations of the regular army. He put a lot of effort into improving the combat capability and material support of the troops entrusted to him. During the few years that he held the position of the ataman of the Astrakhan Cossack army, he managed to solve several problems facing the army and raise the combat capability of the personnel.
Results. According to the results of the study, it can be concluded that N.P. Beklemishev gave 63 years of military service out of almost 80 years of his life, went from a cadet to a lieutenant general, commanded various regular and irregular military formations. In the service, he proved himself to be a competent, demanding, disciplined, initiative officer, faithful to his oath and duty, alien to careerism and intrigue, able to defend the interests of his subordinates in front of his superiors.
Forma bez funkcji. Projektowanie budynków pozbawionych funkcji użytkowej
Authors:   JG Jadwiga Grab, Grab Jadwiga
Published: February 2025

Niniejsza praca podejmuje temat relacji między formą a funkcją w architekturze, koncentrując się na
zagadnieniu formy pozbawionej funkcji użytkowej. Analizowane są teoretyczne i praktyczne aspekty
tego zagadnienia, a także jego znaczenie dla współczesnego projektowania. Forma architektoniczna,
oderwana od funkcji, nie traci swojego sensu – przeciwnie, otwiera nowe możliwości interpretacyjne,
które wzbogacają miejskie środowisko.
Projektowanie zrównoważonych budynków biurowych
Authors:   Politechnika Krakowska im. Tadeusza Kościuszki, Taczalska-Ryniak Anna
Published: February 2025

Publikacja jest artykułem przeglądowym, w którym analizowane są różnorodne aspekty projektowania
obiektów biurowych w kontekście aktualnych uwarunkowań prawnych i technicznych oraz oczekiwań
użytkowników tych obiektów. Analiza kryteriów oceny budynków w procesach popularnych,
wielokryterialnych ocen budynków oraz szerzej – zasad zrównoważonego rozwoju, stanowi podstawę
do prezentacji wybranych aspektów projektowania zielonych biurowców.
Rendimiento Clínico y Diagnóstico en la Aplicación de Guías ASGE 2019 para Pacientes con Coledocolitiasis. Experiencia en Hospital General Regional 220 IMSS Toluca
Authors: Camacho Santoyo Michel , Alarcón Albarrán Dulce María
Published: February 2025

La coledocolitiasis es la presencia de litos a nivel del conducto biliar. La presentación clínica habitual de una coledocolitiasis se traduce en un síndrome ictérico, que a su investigación médica amerita realizar estudios bioquímicos y de imagen. La clasificación de los resultados se validará según las guías internacionales propuestas por la ASGE 2019, lo cual determinará la necesidad de realizar una colangiopancreatografía retrógrada endoscópica. Se realizó una investigación para determinar el rendimiento que presentaron los criterios de ASGE 2019 en nuestro medio para el diagnóstico de coledocolitiasis.
Aula Invertida en la Educación Básica: Ventajas y Desafíos para Mejorar la Participación Estudiantil
Authors: Vera López Franklin Benito , Mendoza Zambrano Nelly Maribel , Valenzuela Espinoza Andrea Elizabeth , López Zambrano Alexandra Maribel , López Zambrano Rubén Atilio
Published: February 2025

El presente trabajo tiene como título “Aula invertida en la educación básica: Ventajas y desafíos para mejorar la participación estudiantil”. Donde la problemática de investigación fue definida por la pregunta ¿Cuáles son las ventajas y desafíos documentados del aula invertida para la educación básica? Llegando a conocer que el aula invertida es una metodología didáctica activa que logra que los estudiantes construyen su propio aprendizaje durante el desarrollo de las actividades. Para desarrollar este estudio, se utilizó un enfoque de tipo cualitativo, mediante una revisión bibliográfica exhaustiva utilizando fuentes académicas como Google, Dialnet, Scielo, Redalyc, etc. Se analizaron 21 trabajos de enorme actualidad que bordeaban su fecha de publicación en los cinco últimos años, en más del 90%. Los hallazgos encontrados fueron: El aula invertida es una metodología donde cambia los momentos de una clase tradicional, permitiendo que la construcción del conocimiento se la realice en casa con la ayuda de una guía de aprendizaje elaborada por el docente y las actividades de refuerzo y tareas se la realice en el salón de clase con la gestión directa del docente, donde sus ventajas son:  Participación de los estudiantes durante todo el proceso de aprendizaje, responsabilidad del alumno en las actividades educativas, aprendizaje al ritmo del educando, integración de las TIC, mayor motivación por parte del estudiante durante las etapas de aprendizaje, fomento del trabajo colaborativo y mejora en la relación docente – educando.
Sospecha de maltrato en adultos mayores de 60 años adscritos a la UMF 56 de León, Guanajuato
Authors: Carranza Tinoco Christian Eugenio , Cobos Azcorra Mariana Montserrat
Published: February 2025

Introducción: La sospecha de maltrato en el adulto mayor es una presunción o indicios de que una persona mayor podría estar siendo víctima de abuso, negligencia o explotación. Este maltrato puede manifestarse de varias formas, como abuso físico, emocional o sexual, mal cuidado o problemas financieros. La sospecha puede pensarse con signos físicos (lesiones inexplicables), cambios en el comportamiento, condiciones de vida inadecuadas o crisis económica. Identificar y abordar estas sospechas es crucial para proteger la salud y el bienestar del colectivo mayor. Objetivo general: Identificar la prevalencia de sospecha de maltrato en adultos mayores de 60 años adscritos a la UMF 56. Material y métodos: Estudio cuantitativo, descriptivo, n=231 pacientes adultos mayores de 60 años; nivel de confianza del 95%, precisión del 3%, proporción esperada del 5%, con uso de una fórmula para estimar una proporción infinita. Resultados: de las mujeres encuestadas con sospecha de maltrato, el 20.7% tuvo una media de 69 años; el 19% mostró datos de maltrato psicológico, 1% físico, 1% económico y 1% abandono. El 58% fueron mujeres dedicadas al hogar, en unión libre. Conclusiones: en el primer nivel, tenemos áreas de oportunidad a través de la prevención oportuna y la valoración médica.
Consumo y venta ilegal de fauna y flora en la vereda la virgen, corregimiento el pando en el municipio de Caucasia, Antioquia
Authors: Gonzalez Revuelta Xiomara Maria
Published: February 2025

La diversidad biologica es esencial para el equilibrio de los ecosistemas, proporcionando servicios vitales para la vida en el planeta. Sin embargo, la caza, recolección y comercio ilegal de fauna y flora han provocado una crisis ambiental que amenaza la sostenibilidad de los recursos naturales. La vereda La Virgen, en el corregimiento El Pando del municipio de Caucasia, Antioquia, enfrenta una creciente problemática debido a estas prácticas, poniendo en riesgo su equilibrio ecológico y el bienestar de sus habitantes. Este estudio busca identificar los factores que impulsan estas actividades ilícitas y proponer estrategias para su mitigación, promoviendo la conservación de la biodiversidad local. A través de un enfoque cualitativo, se emplearon encuestas (estructuradas), grupos de discusión y observación participante para analizar las dinámicas socioeconómicas que fomentan la explotación de los recursos naturales. Los resultados evidencian que, aunque la comunidad reconoce la importancia de la conservación, la falta de alternativas económicas y de educación ambiental perpetúa estas prácticas. A pesar de ello, existe un interés genuino en participar en iniciativas de protección. Por ello, se propone un enfoque integral que combine educación, alternativas económicas sostenibles y participación comunitaria para reducir el impacto ambiental y mejorar la calidad de vida en la región.
Análisis térmico comparativo de materiales de cambio de fase; parafina, sales hidratadas y ácidos grasos, por método de diferencias finitas en Python
Authors: García Gavilánez Robinson José , Garzón Cárdenas Carlos Miguel , Estrella Herrera Juan Carlos
Published: February 2025

En este artículo se compara el desempeño térmico de materiales de cambio de fase (PCM), los materiales que fueron seleccionados para el análisis son tres: parafina, sal hidratada (CaCl₂·6H₂O) y ácido esteárico, para ello se desarrollaron simulación numéricas que usan el método de diferencias fintas implementado en Python, los PCM se analizaron en el contexto operativo de un colector solar plano con el fin de identificar los parámetros clave, como temperatura máxima alcanzada, el tiempo de fusión, la eficiencia térmica y la respuesta a cambios de las variables de diseño como, espesor, irradiación solar y la temperatura del ambiente. Los resultados indican que el PCM parafina alcanza una eficiencia térmica del 85%, lo cual lo destaca en aplicaciones cuyo fin es el almacenamiento prolongado, esto evidenciado por excelente capacidad latente, la sal hidratada presento un tiempo de fusión más rápido y una alta conductividad térmica, en procesos industriales de ciclos rápidos es un material que se posiciona como un potencial candidato, tiene una menor eficiencia por efectos del subenfriamiento, el más equilibrado de los materiales de cambio de fase estudiados fue el ácido esteárico en cuanto a su transferencia de calor y la capacidad de almacenar energía térmica, en proyectos sostenibles donde se necesita estabilidad química es una opción viable. El análisis recalca la importancia de una selección adecuada y precisa de PCM dependiendo de su aplicabilidad, además propone explorar distintas combinaciones entre los materiales de cambio de fase para optimizar el rendimiento de los sistemas, estos hallazgos contribuyen al mejoramiento en el diseño de sistemas térmicos eficiente y también sostenibles, con potenciales aplicaciones en sectores industriales y residenciales. Este análisis resalta la necesidad de una selección precisa de PCM según la aplicación y propone explorar combinaciones híbridas para optimizar el rendimiento. Los hallazgos contribuyen al diseño de sistemas solares térmicos más eficientes y sostenibles, con aplicaciones potenciales en sectores industriales y residenciales.
Use realia for strengthening the speaking skill in third basic year students in rural school
Authors: Nevárez Zambrano María Maricela , Luis Miguel Romero Zambrano  , Nevárez Rosado Daniela Marisol , Loor Bailón Evelyn Tatiana , Moreira Acosta Mayra Auxiliadora
Published: February 2025

This research aim was identifying the effectiveness of using real objects for strengthening the speaking skill of third-year primary school students in the English language class in Ecuador. From this perspective, the research focused on a qualitative assessment based on documentary analysis, with a hermeneutic and systematic approach; as well as field work to analyze the incidence of the use realia for strengthening the speaking skill the English language applied to the context of the students' educational reality. Methods and techniques of educational research were used in its development, such as: interview and observation form; assessing the level of effectiveness and feasibility of the procedures developed for the appropriate use of real objects in the teaching of the English language with emphasis on the development of speaking skills.
Strategy for the Development of International Training At the National Financial Audit Training Agency (Badan Diklat Pemeriksaan Keuangan Negara)
Authors: Yanto Budi , Lestari Ni Putu Nina Eka
Published: February 2025

This research aims to identifies the strategy for the development of international training at Badiklat PKN (the National Financial Audit Training Agency). This study adopts a qualitative approach to answer the research questions, utilizing two primary methods: observation and in-depth interviews. The study recommends a growth-focused strategy for Badiklat PKN’s international training programs, which includes enhancing infrastructure, increasing human resources, improving training materials. In conclusion, this research underscores the significant role of organizational environment in shaping policies for international training at Badiklat PKN, with a focus on enhancing Badan Pemeriksa Keuangan's global position through high-quality training programs
National research
Authors: Hajduković Andrijana , Hohnjec Aleksandra
Published: February 2025

From April 6 to May 20 2024, the Croatian Shorthand Association conducted a national research study on inclusive education, focusing on the attitudes and perceptions of stakeholders within the educational process. The objective of the research was to identify key challenges faced by teachers, principals, and educational specialists and to provide recommendations for enhancing inclusive practices within the education system. A total of 268 actively employed individuals from various educational institutions in the Republic of Croatia participated, with data collected via a survey questionnaire.The results revealed that the majority of respondents are familiar with the concept of inclusive education and believe that their institutions encourage inclusive practices. However, some participants expressed concerns about the lack of resources and support for students with developmental difficulties. Additionally, many respondents recognized efforts by their institutions to provide special attention to students with difficulties, indicating a positive trend toward integrating these students. The research highlights existing challenges in implementing inclusive education and underscores the need for additional training and resources. These findings contribute to a better understanding of inclusive education and provide a foundation for developing strategies to improve practices within Croatia’s education system.
VALLEJO + SCHÖNBERG + BERG + GLASS =
TRILCE
Authors: VILLALBA JORGE
Published: February 2025

La relación entre la Poesía y la Ópera en Iberoamérica continental ha experimentado importantes cambios a lo largo de los siglos, mostrando ambas formas, tendencias convergentes y divergentes en sus expresiones temáticas. La evolución de estas ha supuesto en ocasiones notables avances para ambos campos.
Trilce
(1922), de César Vallejo, es una obra con textos esencialmente musicales, que en ocasiones poseen un carácter operístico. El poemario constituye un cimiento para el siguiente artículo, que analiza algunos de sus poemas desde una perspectiva que incluye ambas disciplinas. El objetivo es identificar puntos de convergencia entre las dos artes, demostrando cómo fueron capaces de integrarse a través del siglo XX y tiempos más actuales.
VOCES TRANS EN LA POESÍA IBEROAMERICANA: SUBJETIVIDADES INÉDITAS EN KÜTRAL VARGAS HUAIQUIMILLA, FLOR BÁRCENAS Y CLAUDIA RODRÍGUEZ
Authors: SÁNCHEZ-OSORES IGNACIO
Published: February 2025

En este ensayo se analiza la política y estética travesti desplegada en la obra de tres escritoras trans-latinoamericanas recientes: la poeta mapuche Kütral Vargas Huaiquimilla, la afrocolombiana Flor Bárcenas Feria y la chilena Claudia Rodríguez. Sostengo que sus tres proyectos poéticos proponen, por medio de diversos tropos y heterogéneos universos líricos, actos encarnados de politización de una subjetividad trans inédita en la poesía latinoamericana: una
política del modelaje travesti
(Vargas Huaiquimilla), una
política de la fluidez travesti
(Bárcenas Feria) y, por último, una
política de la precaridad travesti
(Rodríguez).
JULIO HERRERA Y REISSIG, ASCETA OBSCENO
Authors: ECHAVARREN ROBERTO
Published: February 2025

Este ensayo caracteriza la poética de Julio Herrera y Reissig a través de sus obras principales:
Los éxtasis de la montaña, Los parques abandonados
, los
Nocturnos
, y
La berceuse blanca
. En conjunto derivan de una sensibilidad modernista hispanoamericana que hereda el decadentismo de fin de siglo francés e inglés. Esta modalidad del deseo (véase por ejemplo la
Salomé
de Oscar Wilde) fusiona el erotismo con la mística. La relación de fuerzas planteada por los escritores decadentistas entre los términos “asceta” y “obsceno”, que a primera vista parecen excluirse, tomó un cariz diferenciado en cada caso, conformando facetas de la obra de Herrera. El erotismo se realiza literariamente, en una contemplación poética y una elevación mística, tal vez estimulada por la morfina, que se inyectaba para moderar la arritmia cardíaca. Este erotismo sublimado es a la vez ascético y obsceno. No se trata de represión, sino de una sublimación literaria del impulso erótico en la esfera santa de una experiencia mística. En las varias etapas de la obra de Herrera el lector pasa de la contemplación de la naturaleza, al juego equívoco del galanteo amoroso, a una cabalgata que preludia el encuentro con la muerte, a una veneración de la belleza dormida y a la vez ya muerta. Esta instancia ambigua, en una circunstancia histórica post-teológica, está hecha de paradojas y oxímoron: “Una magnolia narcótica de vida… se abre bajo un blanco crepúsculo de muerte.” Es un “concepto” barroco, significa a dos luces, y forma el núcleo aporético de
Berceuse blanca
.
TESS Hunt for Young and Maturing Exoplanets (THYME). XII. A Young Mini-Neptune on the Upper Edge of the Radius Valley in the Hyades Cluster
Authors: Distler Adam , Soares-Furtado Melinda , Vanderburg Andrew , Schulte Jack , Becker Juliette , Mann Andrew W. , Howell Steve B. , Kraus Adam L. , Kerr Ronan , Barkaoui Khalid , Briceño César , Collins Karen A. , Conti Dennis , Jenkins Jon M. , Limbach Mary Anne , Quinn Samuel N. , Schwarz Richard P. , Seager Sara , Turner Jake D. , Twicken Joseph D. , Winn Joshua N. , Ziegler Carl
Published: February 2025

We present the discovery and characterization of TOI-4364b, a young mini-Neptune in the tidal tails of the Hyades cluster, identified through TESS transit observations and ground-based follow-up photometry. The planet orbits a bright M dwarf (K = 9.1 mag) at a distance of 44 pc, with an orbital period of 5.42 days and an equilibrium temperature of

48

8

−
7

+
9

K. The host star's well-constrained age of 710 Myr makes TOI-4364b an exceptional target for studying early planetary evolution around low-mass stars. We determined a planetary radius of

2.0

1

−
0.08

+
0.10

R

⊕

, indicating that this planet is situated near the upper edge of the radius valley. This suggests that the planet retains a modest H/He envelope. As a result, TOI-4364b provides a unique opportunity to explore the transition between rocky super-Earths and gas-rich mini-Neptunes at the early stages of evolution. Its radius, which may still evolve as a result of ongoing atmospheric cooling, contraction, and photoevaporation, further enhances its significance for understanding planetary development. Furthermore, TOI-4364b’s moderately high transmission spectroscopy metric of 44.2 positions it as a viable candidate for atmospheric characterization with instruments such as JWST. This target has the potential to offer crucial insights into atmospheric retention and loss in young planetary systems.
A Long Spin Period for a Sub-Neptune-mass Exoplanet
Authors: Price Ellen M. , Becker Juliette , de Beurs Zoë L. , Rogers Leslie A. , Vanderburg Andrew
Published: February 2025

HIP 41378 f is a sub-Neptune exoplanet with an anomalously low density. Its long orbital period and deep transit make it an ideal candidate for detecting oblateness photometrically. We present a new cross-platform, GPU-enabled code, greenlantern, suitable for computing transit light curves of oblate planets at arbitrary orientations. We then use the Markov Chain Monte Carlo method to fit K2 data of HIP 41378 f, specifically examining its transit for evidence of oblateness and obliquity. We find that the flattening of HIP 41378 f is f ≤ 0.889 at the 95% confidence level, consistent with a rotation period of P
rot ≥ 15.3 hr. In the future, high-precision data from JWST have the potential to tighten such a constraint and can differentiate between spherical and flattened planets.
On a new haematophagous species of the genus Leptoconops (Holoconops) Kieffer (Diptera, Ceratopogonidae) from the coastal region of West Bengal, India
Authors: Ghosh Lipika , Pal Gouri Sankar , Hazra Niladri
Published: February 2025

Leptoconops (Holoconops) beccussp. nov. is described from India after molecular and morphological data. Both sexes of the new species were fetched from Digha, the coastal region of West Bengal. A revised key to the Oriental species of the subgenus Holoconops Kieffer is also designed.
Comparative morphological study of the gastrointestinal tract of Eutropius niloticus and Oreochromis niloticus from lower river Benue, Nigeria
Authors: Madan Ayush , Gbaaondo Solomon Terzungwe , Nenge James , Akange Edward Terhemen
Published: February 2025

This study investigates the gastrointestinal tract (GIT) morphology of Eutropius niloticus and Oreochromis niloticus which are two economically important fish species from Lower River Benue. Fifty specimens of each species were sampled monthly for a period of three months (November, 2022 – January, 2023) to determine their body and gut measurements. Results revealed that Eutropius niloticus had a mean total length of 24.15±1.90 cm, gut length of 18.00±1.32 cm, and gut weight of 6.09±0.95 g in November, indicating a digestive system enhanced for rapid transit during the period. Conversely, Oreochromis niloticus showed a highly coiled intestine, with a mean gut length of 79.75±9.59 cm and a gut weight of 3.99±1.19 g, suggesting a digestive system adopted to prolonged digestion. Both species showed a significant correlation between body weight and gut length, with r² values of 81.67% and 69.65%, respectively. These findings contribute to the understanding of the feeding strategies and adaptive digestive mechanisms of these species to the dry season fluctuations of River Benue.
Persicaria zhenaiguoi (Polygonaceae, Persicarieae), an overlooked new species from Dabie Mountains, central China
Authors: Wei Yi-Ming , Zhu Zhen-Hua , Lei Shu-Qing , Li Bo
Published: February 2025

Persicaria zhenaiguoi Bo Li, a remarkable new species discovered from the summit of Tiantangzhai Peak of Dabie Mountains in Hubei Province, central China, is described and illustrated. Based on its spicate inflorescences, ciliate ocreae, and the absence of prickles, the species is placed in P. sect. Persicaria. Within this section, P. zhenaiguoi most resembles P. orientalis and P. viscosa in gross morphology, particularly in the presence of densely spreading villus throughout. However, the new species can be easily distinguished from these two similar taxa by its nearly sessile leaves, which are lanceolate in shape with broadly cuneate to rounded bases, membranous ocrea with a small circle of green leaf-like wing, sparse and interrupted inflorescences, glabrous peduncles, greenish tepals, and ovoid achenes with grooved surfaces. Diagnostic characteristics, along with comparative photographs of the three related species, are provided, as well as a detailed morphological description and information on the distribution and habitat of the new species.
Floristic patterns in the Andes of northern Patagonia’s forests, Argentina: towards integrating ecological responses with expert-based and unsupervised classification methods
Authors: Joelson Natalia Zoe , Simon Alois , von Lampe Friedemann , Loguercio Gabriel Ángel , Zerbe Stefan , Leuschner Christoph , Walentowski Helge
Published: February 2025

Aims: To explore the relationship between plant communities and key environmental drivers in the Andes of northwest Patagonia, Argentina, and to evaluate the applicability of traditional phytosociological definitions to this region. Methods: We conducted 141 vegetation samples using a stratified systematic sampling design. This was done along two steep gradients of aridity and temperature, which are further modified by local factors that include successional changes due to fire and soil variation. We employed a series of multivariate approaches, including hierarchical clustering, Indicator Species Analysis (ISA), restricted Monte Carlo permutation tests, and both constrained and unconstrained ordinations, to identify (a) the main plant community types, (b) their representative species, and (c) the primary drivers of variation in species composition. Finally, we compared the obtained groups and species to associations described by earlier expert-based classifications. Results: From the set of analyses, we identified six different plant community types with 241 recorded species. We found significant differences across communities’ species composition and their environmental indicators. Among the considered environmental variables, elevation and annual precipitation had the strongest effect on species composition. Additionally, variation in composition was significantly related to forest structure, land use and soil characteristics. We further outlined the influence of locally biased classifications based on a predominance of sampling in areas western to the Andes in classification systems developed in the region. Conclusion: Our analysis allowed us to identify the most relevant environmental drivers and indicator species of the six classified plant communities based on numerical methods. The findings highlight the importance of considering full ecological gradients and communities’ responses for developing stable classification approaches.

Taxonomic reference: Anton and Zuloaga (2023).

Abbreviations: db-RDA = distance-based Redundancy Analysis; ISA = Indicator Species Analysis; NMDS = Non-metric Multi-Dimensional Scaling.
Social Media and Subjective Well-Being in Older Adults: The Role of Social Support, Self-Efficacy, and Depressive Symptoms
Authors: Yu Ke , Liang Tianxing , Chen Ruishan , Tao Wuhai
Published: February 2025

Purpose

To explore how social media affects older adults' subjective well-being (SWB) through underlying mechanisms.

Method

Path analysis was performed with 106 Chinese older adults to examine the effects of social media's interactive communication, information acquisition, and leisure and entertainment on SWB via social support, self-efficacy, and depressive symptoms.

Results

The model fit well (χ
2
/
df
= 5.28, goodness of fit index = 0.86). Social support mediated the positive relationship between interactive communication and SWB, and self-efficacy mediated the positive relationship between information acquisition and SWB. Leisure and entertainment activities on social media showed no significant association with SWB.

Conclusion

Social media addresses social support deficits from physical limitations and enhances self-efficacy through information retrieval, thus improving SWB. Findings elucidate how social media influences SWB in older adults, offering theoretical guidance for interventions to enhance their well-being. [
Journal of Geronto-logical Nursing, xx
(xx), xx–xx.]
Dual Application of Methotrexate Improves Functional and Anatomical Outcomes in Diabetic Tractional Retinal Detachment
Authors: Safwat Abdallah , Abdullah Mohamed , Abdelhalim Ahmed Shawkat , Hassanien Rabei , Mourad Khaled , Moustafa Mohamed Tarek
Published: February 2025

Background and Objective

This study evaluated the use of a dual-delivery methotrexate (MTX) strategy for diabetic tractional retinal detachment (TRD). Diabetic retinopathy (DR) is a leading cause of blindness. Inflammation plays a key role in TRD, and MTX has anti-inflammatory properties.

Patients and Methods

This is a pilot study that included 60 patients with TRD. They were block randomized to either MTX with pars plana vitrectomy (PPV) (
n
= 30) or PPV alone (control,
n
= 30). MTX was added to the irrigation fluid during surgery and an intra-silicone injection at the end. One month after silicone oil removal, visual acuity (VA), multifocal electroretinography (mfERG), and spectral-domain optical coherence tomography (SD-OCT) were assessed.

Results

One month after silicone oil removal, VA and mfERG were significantly better with a lower prevalence of epiretinal membranes, disorganization of retinal inner layers, and cystic macular changes by SD-OCT in the MTX group.

Conclusion

This study found that dual-delivery MTX during PPV is a promising strategy to improve functional and anatomical results in diabetic TRD.

[Ophthalmic Surg Lasers Imaging Retina
2025;56:XX–XX.]
Des spectroscopistes en support des études atmosphériques et climatiques du LMD
Authors: Perrin Agnès , Tran Ha , Hartmann Jean-Michel
Published: February 2025

Cet article décrit l'arrivée au Laboratoire de météorologie dynamique, en 2016, de trois chercheur(se)s en spectroscopie moléculaire du CNRS. Nous expliquons les raisons qui ont motivé ce changement d'affectation, sur quelles bases scientifiques s'est faite leur intégration réussie, et comment se dessine d'ores et déjà un futur riche en projets.