bluuebunny/crossref_metadata_2025 huggingface dataset:
PEMBERDAYAAN MASYARAKAT MELALUI PELATIHAN TATALAKSANA KESEHATAN DAN KEBERSIHAN KANDANG KAMBING DI DESA AIR SATAN KECAMATAN MUARA BELITI KABUPATEN MUSI RAWAS
Authors: Teguh Karyono  , Bagus Dimas Setiawan
Published: November 2022

ABSTRAKKegiatan Pengabdian Kepada Masyarakat (PKM) ini merupakan upaya memberikan keterampilan mengenaitatalaksana kesehatan dan kebersihan kandang kambing. Tatalaksana kesehatan dan kebersihan kandang ternaksebagai bagian dari manajemen peternakan merupakan salah satu faktor penentu keberhasilan suatu usaha peternakan,pada akhirnya bertujuan untuk meningkatkan pendapatan masyarakat dan menciptakan lapangan kerja yangdilaksanakan melalui pendampingan kelompok ternak. Kegiatan PKM ini dilakukan di Desa Air Satan KecamatanMuara Beliti Kabupaten Musi Rawas. Metode yang digunakan adalah metode ceramah (pemberian edukasi tentangsyarat dan pentingnya kesehatan dan kebersihan lingkungan kandang yang baik), Focus Group Discussion (FGD), danpraktik secara langsung. Pelatihan masyarakat khususnya masyarakat petani ternak menjadi tumpuan harapan untukpeningkatan kualitas sumber daya manusia (SDM). Hasil yang didapat diketahui bahwa kegiatan PKM melaluiedukasi yang diberikan dapat meningkatkan pengetahuan peternak tentang lingkungan kandang ternak yang sehatsehingga terbentuk kesadaran untuk memperbaiki lingkungan kandang. Perbaikan kesehatan dan kebersihan kandangyang dilakukan berdasarkan Focus Group Discussion berupa (1) Kesehatan lingkungan kandang perlu diperhatikanoleh peternak dan dinas yang terkait, seperti Poskeswan Kesehatan Hewan dan Dinas Peternakan (2) perbaikan letakkontruksi kandang, tempat pakan dan minum ternak sesuai dengan syarat kandang sehat; (3) perbaikan saluran limbahternak; (4) pembuatan tempat penampungan limbah; dan pembuatan pupuk organik.Keywords: Kesehatan dan Kebersihan Kandang, Ternak Kambing, Pemberdayaan Peternak
SOSIALISASI DALAM MEMANFAATKAN LIMBAH PERTANIAN SERTA TEKNIK BUDIDAYA KENTANG MERAH (Solanum tuberosum, L.) PADA SPESIFIK LAHAN KERING SUB OPTIMAL DI DESA WATAS MARGA, KECAMATAN CURUP SELATAN KABUPATEN REJANG LEBONG PROVINSI BENGKULU
Authors: Adnan  , Mardia Apriansi  , Febri Nur Pramudya
Published: November 2022

ABSTRAKHasil survei ke wilayah PKM dengan Luas pemukiman 5 ha, lahan persawahan 52 ha, lahan perkebunan 5 ha.Lahan tegal/ladang 10 ha., terletak 600 meter dari permukaan laut. Penduduk desa Watas Marga berasal dari sukusuku yang berbeda-beda, dimana mayoritas penduduk lokal dan penduduk tranmigrasi dari Pulau Jawa. Hasil surveydi lapangan profesi masyarakat yang berbedaa-beda, sebagian besar mata pencahariannya dibidang pertanian, buruh,perternakan dll. Dilihat kondisi sumber alamnya sangat potensial dan belum maksimal untuk dimanfaatkan secaramaksimal seperti limbah jerami hasil panen padi dan sisa bahan organik rumah tangga. Dengan kondisi tersebutuntuk melakukan sosialisasi serta dilakukan pelatihan untuk diadakan mendemontrasikan pembuatan pupukkompos padat dan cair. Dengan sasarannya kelompok PKK, dan remaja. Hasil pelaksanaannya :1).Telahdilaksanakan sosialisasi dan pelatihan tentang pembuatan pupuk organic dari limbah jerami padi dan limbah rumahtangga pada sasaran kelompok PKK dan remaja di Desa Watas Marga sesuai dengan scedul yang dibuat. 2) Telahdilakukan hasil pelatihan untuk pembuatan pupuk kompos hasil limbah jerami padi sesuai dengan scedulnyayaitubulan Oktober sampai dengan Nopember 2019. 3).Telah dilaksanakan aplikasi pupuk kompos padat pada tanamanpekarangan warga Desa Watas Marga untuk menciptakan lingkungan asri dan nyaman pada binaan kelompok PKKdan kelompok remaja Desa Watas Marga.Kata Kunci: Sosialisasi, kelompok PKK, Pupuk KomposABSTRACT
I Can’t: Acute Sexual Impotence and the Flesh
Authors: Pearl J. Leavitt ,   Zeta Books
Published: November 2022

Since Husserl’s phenomenological analyses of the living body (Leib) in Ideas II, the subjective experience of the body, what later French thinkers will name the flesh, has been particularly marked by its capacity for action—its potency. This privileging of the acting flesh, the potent organ, is echoed throughout the subsequent phenomenological tradition. For this tradition, from de Biran and Husserl, to Merleau‑Ponty and Henry, the flesh is distinguished from the mere body (Körper) by its unique capacity to act. For the later French tradition to be flesh is to be will, and to be will is to be action. Impotence (impuissance) appears as external resistance. In the present investigation, I challenge this trajectory of the flesh through a phenomenological investigation of the unique phenomenon of acute sexual impotence. In this way, it will be shown that l’impuissance (impotence) can be located not only in the objectivity of opposition within the world, on the organic or objective body (le corps, Körper), but within the immanence of the flesh (la chair, Leib) itself. Indeed, the experience of incarnate l’impuissance provides a unique phenomenological access to the incomplete synthesis of the carnal flesh—a synthesis that remains, by phenomenological necessity, run through with ruptures and gaps that function as its constitutive excess.
Phenomenology of the Stranger
Authors: Dreher Jochen ,   Zeta Books
Published: November 2022

The essay presents a relational concept of the stranger parting from and at the same time going beyond Alfred Schutz’s famous and controversial conception of “The Stranger.” Not only the subjective viewpoint of the stranger entering an in‑group – as in the Schutzian outline – is relevant for the construction of strangeness, but also the interactional context and the receiving in‑group with its respective patterns of culture. For strangeness is a relational concept, it is only constructed in relationships of individuals and groups; it is an ascription or “label” that is activated in interaction processes. Within in‑ and out‑group constellations, the stranger is objectified by social typification, which may be based on a de‑subjectivation and reification of the respective Other. Relational strangeness refers to the diverse possibilities of the social construction of the stranger, always taking into consideration the individuals involved in in‑ and out‑group relations.
Imagination of history in Stevan Sremac's Short stories from antique books
Authors: Rajović Dragana
Published: November 2022

The subject of this paper are historical stories of Stevan Sremac. Their artistic value lags behind the value of his realistic prose. Bearing in mind the style of the writer's historical narratives, it is concluded that the writer's primary motive in writing was "national-educational action" and not literary creativity. Following the trail of legends and traditions, the author neglected historical facts, which resulted in artistic inconclusiveness. Stevan Sremac tried to balance historical facts with artistic vision and legends.
Effects of acute aerobic exercise on fatmetabolism in pre- and postmenopausal women of comparable body mass index
Authors: Hofmann K , Hanke LH , Bjarnason-Wehrens B , Diel PR , Flenker U , Wacker AJ
Published: November 2022

Problem: With menopause, the risk of cardiovascular diseases (CVD) increases significantly. A possible molecular mechanism is an estrogen-related change in fat metabolism. Endurance training has been demonstrated to reduce the risk of CVD and to have an impact on fat metabolism (FM). This study aims to analyze the ability of pre- (preW) and postmenopausal women (postW) of comparable body mass index (BMI) to activate their FM during endurance training. Methods: 12 preW and 12 postW were included. Serum Triglyceride, LDL, HbA1C, estradiol and body composition data were determined. The respiratory quotient (RQ) was determined during moderate 30-minute exercise (60% of the 4 mmol threshold) on an ergometer. Results: While the BMI of preW and postW was comparable, body fat (BF) (p=0.001), lean body mass (LBM) (p=0.001) and abdominal girth (AG) (p=0.003) were significantly different. Significant group effects could also be identified in HbA1c (p=0.001), cholesterol (p=0.001) and LDL (p=0.000) serum concentrations. RQ decreased during 30 minutes of cycling in preW and increased in postW (p=0.010) over time. Discussion: The higher AG and BF and the lower LBM demonstrates the change in body composition in postW. An accumulation of fat, especially in the trunk region, goes along with an increase of CVD in postW, even with a normal BMI. Conclusion: It is evident that postW show altered lipid metabolism compared to preW. Key Words: Menopause, Cardiovascular Risk Factor, Aerobic Training, Metabolism
The Effectiveness of Developing Interactive Learning Media on Learning Basic Concept Material
Authors: Ambarita Charles Fransiscus , Sirait Dita Eka Pertiwi , Pandimun Ambarita Dody Feliks
Published: November 2022

This study’s aim was to determine the interactive learning media effectiveness on the Learning Basic Concept material. The ADDIE Robert Maribe Branch approach is being used in this research and development. Regarding product effectiveness, in the field trial conducted, the t-test result was obtained tcount = 5.09 while ttable = 1.699 at significance level of 0.05. This shows that tcount > ttable, then Ho is rejected and Ha is accepted, so that interactive learning media based Lectora Inspire is effectively used in the learning process.
Current Trends in Business and Management: A Review
Authors: Sirohi Aakash , Kejriwal Aditya , Hossain Mohammad Kamrul
Published: November 2022

To survive in the current unstable economic environment, every organization that operates needs to be able to adapt. The pace of change has accelerated substantially in recent years, and businesses and organizations now deal with change on a daily basis. Organizations must adapt to shifting environmental conditions and ongoing change in the complex and competitive global business environment of today to stay competitive and profitable. There is fierce competition today. The market has evolved, there are more competitors, and new firms have entered. Additionally, Slovak enterprises must pay close attention to market changes and respond to both domestic and foreign market demands .Our time is one that is genuinely innovative. Without technical advancements, life would not be the same as it is today. The world market is undergoing rapid change. In order to improve their revenue, more and more businesses are currently going internationally. Today's global business trends center on utilizing cutting-edge technology, studying consumer behavior. This article describes the current state of the global business management area and discusses the newest business theories and the technology used to successfully execute them.
Effect of Different Growing Media on Growth, Establishment and Survival of Passion Fruit (Passiflora edulis Sims.) cv. Coorg Purple
Authors: Lodhi Paritosh , Topno Samir E. , Prasad V. M.
Published: November 2022

The current study was conducted in the Research Field at the SHUATS, Prayagraj, Department of Horticulture, from 2020 to 2021. Seven treatments were used in the experiment, which included growing media (farm yard manure, vermicompost, and poultry manure) on passion fruit. The experiment was carried out using a Randomized Block Design (RBD). the treatments were T1 Control (RDF 100% NPK)/ Plant, T2 Vermicompost (50%) +Poultry Manure (25%) + FYM (25%), T3 Vermicompost (25%) +Poultry Manure (50%) + FYM (25%), T4 Vermicompost (25%) + Poultry Manure (25%) + FYM (50%), T5 Poultry Manure (50%) + FYM (50%), T6 Poultry Manure (50%) + Vermicompost (50%) and T7 FYM (50%) + Vermicompost (50%). The results from the present investigation revealed that treatment T7 followed by T4 and T5 was found superior in terms of Survival percentage and growth parameters of Passion fruit in growing media i.e. (Vermicompost, Poultry manures, and Farm yard manures), in an agro-climatic condition of Prayagraj in terms of cost of cultivation maximum cost was recorded in treatment T3 and minimum in treatment T1.
Analysis of Oil Pollution Intensity in Niger-delta, Nigeria Using Normalized Difference Vegetation Index
Authors: C. Peter Chibuike , M. Ezeogu Chibuike , Brisibe Oyintare
Published: November 2022

There has been an increase in the level of oil spillage across the Niger Delta region of Nigeria since the advent of crude oil exploration. The effects of oil pollution cannot be overemphasized, as it is not only detrimental to human health but also to the ecosystem at large. Geographic Information Systems (GIS) and Remote Sensing (RS) are veritable tools in Environmental management. Normalized Difference Vegetation Index was used as GIS and RS tools to determine the intensity of pollution caused by oil spillage in the Niger Delta area for the past decade (2010-2020). The land sat imageries of the study area were acquired and NDVI analyses were performed. Five NDVI types were used with the equation NDVI=(NIR-Red)/(NIR+Red). The total land mass covered was 109,582 sq.Km. The results showed that in 2010, Healthy Vegetation was 37,352 sq. Km, which was 34 percent of the total land mass. In 2015, Poor Health vegetation accounted for the highest land mass with a total of 41,976 sq. Km, while Moderate Health Vegetation had the lowest land mass of 12,830 sq.Km. In 2020, Poor Health Vegetation accounted for the highest land mass of 38,324 sq.Km representing 35 Percent of the total land mass while Increasing Vegetation had 13,452 sq.Km with 12 Percent making it the lowest NDVI type for the year.

From the results, there was evidence showing of increased Normalized Difference Vegetation Index (NDVI) negative values across the years in the study area. This was an indication of the high level of pollution.

There is a need to mitigate oil spillage to its barest minimum in the study area.
Role and Complication of Existing and Newer Calcium Channel Blockers in Hypertension Treatment
Authors: Aljehani Salman Abdulaziz , Alshahrani Khalid Ahmed , Alhumidi Nidaa Turki , Ghamdi Alya Saeed Al , Alishaq Mohammed Ahmed , Alawad Buthaynah Ahmed , Albishi Areej Habib , Albalawi Mohammad Ahmad , Alkhayri Ahmed Hassan , Alotaibi Turkiyah Sharar , Alahmadi Ashwaq Abdulhamid
Published: November 2022

Hypertension is the major risk factor for cardiovascular disease and early death worldwide. Early and prompt management of hypertension can significantly prevent complications. Owing to the extensive usage of antihypertensive drugs, worldwide mean blood pressure has stayed constant or declined to some extent during the previous four decades although high prevalence in reported in developing countries. CCBs are a class of drugs that are commonly used to lower blood pressure and are structurally and functionally diverse. They are generally well accepted and have less adverse effects. The purpose of this research is to review the available information about role and complication of existing and newer CCBs in hypertension treatment. As soon as CCBs were utilized to treat hypertension, they earned a reputation as potent antihypertensives that significantly and consistently lowered blood pressure in people of all ages and races in mono and combination therapy. CCBs work by reducing peripheral vascular resistance. Newly available CCBs may be therapeutically more effective in treatment of hypertensive individuals with chronic kidney disease than the L-type CCB. Lercanidipine is a third generation CCB that has fewer side effects and is used in people with a high risk of target organ damage and elderly patients. CCBs are associated with certain side effects including peripheral edema, hypotension, headaches, conduction abnormalities among various others. Some studies have also associated use of CCBs with modest risk increase for myocardial infarction and heart failure. Further clinical research is required to elaborately study the efficacy of CCBs in management of hypertension.
PI3Kβ inhibition enhances ALK‐inhibitor sensitivity in ALK‐rearranged lung cancer
Authors: Talwelkar Sarang S. , Mäyränpää Mikko I. , Schüler Julia , Linnavirta Nora , Hemmes Annabrita , Adinolfi Simone , Kankainen Matti , Sommergruber Wolfgang , Levonen Anna‐Liisa , Räsänen Jari , Knuuttila Aija , Verschuren Emmy W. , Wennerberg Krister
Published: November 2022

Treatment with anaplastic lymphoma kinase (ALK) inhibitors significantly improves outcome for non‐small‐cell lung cancer (NSCLC) patients with ALK‐rearranged tumors. However, clinical resistance typically develops over time and, in the majority of cases, resistance mechanisms are ALK‐independent. We generated tumor cell cultures from multiple regions of an ALK‐rearranged clinical tumor specimen and deployed functional drug screens to identify modulators of ALK‐inhibitor response. This identified a role for PI3Kβ and EGFR inhibition in sensitizing the response regulating resistance to ALK inhibition. Inhibition of ALK elicited activation of EGFR, and subsequent MAPK and PI3K‐AKT pathway reactivation. Sensitivity to ALK targeting was enhanced by inhibition or knockdown of PI3Kβ. In ALK‐rearranged primary cultures, the combined inhibition of ALK and PI3Kβ prevented the EGFR‐mediated ALK‐inhibitor resistance, and selectively targeted the cancer cells. The combinatorial effect was seen also in the background of TP53 mutations and in epithelial‐to‐mesenchymal transformed cells. In conclusion, combinatorial ALK‐ and PI3Kβ‐inhibitor treatment carries promise as a treatment for ALK‐rearranged NSCLC.
Constructing a Stable and Efficient Buried Heterojunction via Halogen Bonding for Inverted Perovskite Solar Cells
Authors: Zhang Caiyi , Shen Xiangqian , Chen Mengjiong , Zhao Yan , Lin Xuesong , Qin Zhenzhen , Wang Yanbo , Han Liyuan
Published: November 2022

The inverted perovskite solar cell has made great progress in recent years and the quality of the heterojunction has played a key role. Here, a series of halide‐substituted benzoic acid molecules are investigated as the bridge between nickel oxide and the perovskite, constructing a stable and efficient buried heterojunction via halogen bonding. The designed molecules are anchored at the surface of NiO by the coordination between the carboxyl and hydroxyl groups. On the opposite site of the molecules, strong halogen bonding is formed by binding the undercoordinated I− at the buried surface of the perovskite, which inhibits the generation of I2 under continuous light soaking and thereby suppresses the formation of voids. Moreover, the highly directional halogen bonding is beneficial for the oriented growth of perovskite crystals, which accelerate the carrier transport. As a result, the champion device yields a power conversion efficiency (PCE) of 22.02% and the encapsulated device maintains 91.86% of the initial PCE under continuous 1‐sun illumination at 55 °C for 1000 h.
Vitamin Natural Molecule Enabled Highly Efficient and Stable Planar n–p Homojunction Perovskite Solar Cells with Efficiency Exceeding 24.2%
Authors: Liu Bin , Wang Yuqi , Wu Yanjie , Zhang Yuhong , Lyu Jiekai , Liu Zhongqi , Bian Shuhang , Bai Xue , Xu Lin , Zhou Donglei , Dong Biao , Song Hongwei
Published: November 2022

The defect passivation and interface energetics‐modification between perovskite and transport layers are significant for the further improvement of efficiency and stability of perovskite solar cells (PSCs). Here, a double‐layer modification engineering strategy is employed by different functionalized natural vitamins into the electron transport layer and perovskite, respectively. Considering the different role of each functional layer in PSCs, the vitamin C (VC) with high conductivity is introduced into SnO2, showing electron mobility enhancement, an interface energy‐levels offsets reduction, and enhanced interfacial charge transfer. Meanwhile, antioxidant vitamin D2 (VD2) with multiple passivating functional groups is introduced into the perovskite bulk to moderately tailor its intrinsic characteristics. The surface energetics of perovskite are changed from n‐type to p‐type, the thickness of the p‐type perovskite is 80 nm, thus the spontaneous n–p homojunction is formed in perovskite caused by VD2, which increases the built‐in electric field and the efficiency of perovskite hole extraction. The synergistic effect of VC and VD2 better heightens the charge extraction efficiency and achieves charge‐carrier transport balance in PSCs. The optimum device achieves a power conversion efficiency of 24.20% and a fill factor of 81.01% with negligible hysteresis. This efficiency is among the best PSCs employing natural molecules reported so far.
Patients with DeSanto–Shinawi syndrome: Further extension of phenotype from Italy
Authors: Pasquali Daniela , Torella Annalaura , Grandone Anna , Luongo Caterina , Morleo Manuela , Peduto Cristina , di Fraia Rosa , Selvaggio Lucia Digitale , Allosso Francesca , Accardo Giacomo , Zanobio Maria Teresa , Maitz Silvia , Mariani Milena , Selicorni Angelo , Banfi Sandro , Nigro Vincenzo ,   TUDP Study Group
Published: November 2022

Here we describe three patients with neurodevelopmental disorders characterized by mild‐to‐moderate intellectual disability, mildly dysmorphic features, and hirsutism, all of which carry de novo sequence variants in the WW domain‐containing adaptor of the coiled‐coil (WAC) gene; two of these—c.167delA, p.(Asn56I1efs*136) and c.1746G>C, p.(Gln582His)—are novel pathogenic variants, and the third—c.1837C>T, p(Arg613*)—has been previously described. Diseases associated with WAC include DeSanto–Shinawi syndrome; to date, de novo heterozygous constitutional pathogenic WAC variants have caused a syndromic form of intellectual disability and mild dysmorphic features in 33 patients, yet potential associations with other clinical manifestations, such as oligomenorrhea and hyperandrogenism, remain unknown, because the phenotypic spectrum of the condition has not yet been delineated. The patient bearing the novel c.167delA WAC gene variant presented a normal psychomotor development, oligomenorrhea, hyperandrogenism, and hirsutism, and hirsutism was also observed in the patient with the c.1746G>C WAC gene variant. Hypertrichosis and hirsutism have been described in nine DeSanto–Shinawi patients, only in 17 of the 33 aforementioned patients thus far reported this aspect, and no hormonal‐pattern data are available. In conclusion, we note that the pathogenic c.167delA WAC variant may be associated with a mild phenotype; and in addition to the neurodevelopmental problems nearly all DeSanto–Shinawi patients experience (i.e., intellectual disability and/or developmental delay), we recommend the addition of mild dysmorphic features, hirsutism, and hypertrichosis to this clinical presentation.
Conductive and antibacterial scaffold with rapid crimping property for application prospect in repair of peripheral nerve injury
Authors: Zhang Hai‐qiang , Lan Dong‐wei , Li Xia , Li Zhi , Dai Fang‐Yin
Published: November 2022

Peripheral nerve injury (PNI) is a severe clinical disease leading to the loss of sensory and motor function and even lifelong disability of patients. Nerve scaffolds with conductive materials are beneficial to PNI repair and regeneration through the recovery of electrical signals transmission and regulation of nerve cell membrane function. In this study, composite poly(lactide‐co‐glycolide) (PLGA)/Ti3C2Tx (MXene) membranes with different content of MXene were fabricated by electrospinning, and these fibrous membranes showed favorable mechanical property for supporting nerve regeneration. With loaded MXene, the electrospun membranes exhibited good antibacterial property that the antimicrobial rate was as high as 80%, which is conducive to the prevention of wound inflammation after stent implantation. The loaded MXene also improved the hydrophilicity and conductivity of the electrospun composite membranes, which provided good biocompatibility for cell growth. Interestingly, treating in 75% ethanol solution made fabricated PLGA/MXene membranes rapidly crimp into stable nerve conduits for implanted application. These fabricated PLGA/MXene membranes showed good potential for nerve repair and have a good prospect for nerve conduit application.
Assessing how well students understand the molecular basis of evolution by natural selection
Authors: Sievers Matt , Reemts Connor , Dickinson Katherine J. , Mukerji Joya , Beltran Ismael Barreras , Theobald Elli J. , Velasco Vicente , Freeman Scott
Published: November 2022

Researchers have called for undergraduate courses to update teaching frameworks based on the Modern Synthesis with insights from molecular biology, by stressing the molecular underpinnings of variation and adaptation. To support this goal, we developed a modified version of the widely used Assessing Conceptual Reasoning of Natural Selection (ACORNS) instrument. The expanded tool, called the E‐ACORNS, is explicitly designed to test student understanding of the connections among genotypes, phenotypes, and fitness. E‐ACORNS comprises a slight modification to the ACORNS open‐response prompts and a new scoring rubric. The rubric is based on five core concepts in evolution by natural selection, with each concept broken into elements at the novice, intermediate, and expert‐level understanding. Initial tests of the E‐ACORNS showed that (1) upper‐level undergraduates can score responses reliably and quickly, and (2) students who were just starting an introductory biology series for majors do not yet grasp the molecular basis of phenotypic variation and its connection to fitness.
An interactive virtual reality model for enhancing safety training in construction education
Authors: Abotaleb Ibrahim , Hosny Ossama , Nassar Khaled , Bader Sahar , Elrifaee Mohamed , Ibrahim Salma , El Hakim Yasmin , Sherif Mohamed
Published: November 2022

One of the main factors leading to fatalities in construction sites is the inefficiency of safety training programs. This article presents an immersive and interactive virtual reality (VR) model for safety training, which is an advanced and more comprehensive version of previously developed VR models in the literature. The novelty of this research is present in the proposed general safety training model that is fully immersive and interactive, that is built based on the concepts of experiential learning; where users learn from their mistakes rather than being passive learners in a virtual environment. The model, which was developed using the Unity® platform and C#, contains 12 scenario‐based hazards with programmed interactions and responses to the actions of the trainees. The developed model was tested for two aspects: (1) the ability to achieve learning outcomes and supersede traditional training, and (2) user experience and usability. Using an experimental setting and statistical tests, the developed model has shown statistical significance when it comes to its efficiency in enhancing hazard identification and mitigation skills as opposed to traditional training. The model also performed well in terms of usability and user experience, and important lessons were extracted for future VR development in construction education applications. This research strengthens the utility of VR as an effective tool for experiential learning; which enables future research in exploring how computer applications can improve experiential learning even further.
Sex differences in adults with acute myeloid leukemia and the impact of sex on overall survival
Authors: Stabellini Nickolas , Tomlinson Benjamin , Cullen Jennifer , Shanahan John , Waite Kristin , Montero Alberto J. , Barnholtz‐Sloan Jill S. , Hamerschlak Nelson
Published: November 2022

Background

There is a male predominance of acute myeloid leukemia (AML) incidence, but survival data are conflicting. The objective of this study is to carry out a comprehensive analysis of sex differences in AML, and to investigate the impact of sex disparities in survival.

Methods

The cohort included patients ≥18 years diagnosed with AML (2010–2022). Demographics, treatment patterns, treatment adverse events, and survival were analyzed. The population was described and compared by sex, and sex‐based risks and associations were obtained via Cox proportional‐hazards regression.

Results

In total, 1020 AML patients were analyzed (57.4% males), with lower risk of death for females (aHR = 0.41, 95% CI 0.26–0.66). Among females, BMT (aHR = 0.51, 95% CI 0.27–0.97), hospitalization record (aHR = 0.65, 95%CI 0.45–0.93), and higher appointment completion rates (aHR = 0.98, 95% CI 0.98–0.98) were associated with lower risk of death. Overall, and similarly in males, higher age at diagnosis (aHR = 1.03, 95% CI 1.02–1.04) and a TP53 mutation (aHR = 2.24, 95% CI 1.69–2.97) were associated with higher risk of death.

Conclusion

Sex differences exist in both AML incidence and overall survival. Treatment and health care factors should be addressed by caregivers and public policies developed to reduce mortality rates and mitigate existing sex differences.
Accidental displacement of a dental implant into the nasal cavity: Report of a rare case
Authors: Safi Yaser , Mortazavi Hamed , Sadeghian Ali , Hazrati Parham
Published: November 2022

Through radiographic evaluation to discover the location of a displaced implant, it was revealed that the implant had migrated to the middle meatus of the nasal cavity. The patient had no signs or symptoms, and no inflammation was observed radiographically. The implant was removed under endoscopy through the nostril.
Effects of early season soil moisture and nitrogen applications on tolerance of quizalofop‐resistant rice to quizalofop
Authors: Godara Navdeep , Norsworthy Jason K. , Butts Thomas R. , Roberts Trenton L. , Gbur Edward E.
Published: November 2022

Quizalofop‐resistant rice (Oryza sativa L.) allows for postemergence applications of quizalofop. Previous research reported that soil moisture availability strongly influences the response of grass species to aryloxyphenoxypropionate herbicides. Experiments were conducted at Stuttgart, AR, and at Colt, AR, in 2021 to investigate the influence of early season soil moisture and nitrogen (N) applications on the tolerance of quizalofop‐resistant cultivars to sequential quizalofop applications. The experiment was implemented as a two‐factor, randomized complete block design. The factors evaluated were cultivar (PVL02 and RTv7231 MA) and herbicide treatment (nontreated control; nontreated control fertilized with ammonium sulfate [AMS] at 100 lb acre−1 and surface irrigated at the two‐leaf stage; sequential quizalofop applications at 1× and 2× rates; sequential quizalofop at 1× and 2× rates surface irrigated at the two‐leaf stage; and sequential quizalofop applications at 1× and 2× rates fertilized with AMS at 100 lb acre−1 then surface irrigated at the two‐leaf stage). Sequential quizalofop applications were applied at the two‐leaf and five‐leaf stages, with 1× and 2× rates of quizalofop being 0.11 and 0.22 lb a.i. acre−1, respectively. RTv7231 MA injury was 2‐ to6‐percentage points higher than PVL02 at all visual injury ratings averaged across treatment and location. Sequential quizalofop applications caused 1–9% visible injury to quizalofop‐resistant cultivars pooled over locations and rating timings. Growers could consider environmental conditions before herbicide applications to mitigate the risk of injury to quizalofop‐resistant cultivars from quizalofop, and drier soil conditions could be used for quizalofop applications onto rice compared with saturated soil conditions.
Dripping and underground river waters shed light on the ecohydrology of a show cave
Authors: Addesso Rosangela , Morozzi Pietro , Tositti Laura , De Waele Jo , Baldantoni Daniela
Published: November 2022

Water and air flows connect underground ecosystems to the surface, affecting the cave chemical and physical properties. Together with the visitor's fluxes in show caves and occasional presence of cavers in wild caves—excluding the large amounts of organic supply by bat or bird colonies or large sinking rivers bringing vegetal debris—fluid flows are the main means of transport of nutrients into the normally oligotrophic cave environment. The aim of this work was to investigate the chemical characteristics of waters in the Pertosa‐Auletta Cave (Italy), focusing on drip water and on the underground Negro river, seasonally and in different areas of the cave. In particular, three trails with different environmental characteristics and tourism pressure were investigated in order to shed light on the processes affecting the ecological equilibrium of the hypogean ecosystem. Dripping and flowing river waters, both rich in Ca because of their interaction with carbonate rocks, show distinct chemical signatures regarding the other chemical elements (especially K and Mg) due to lithological and hydro‐dynamical differences. Moreover, water chemistry is affected by the seasonality in the pluviometric regime owing to the subsequent variability in the dilution effect. Bat colonies, dwelling mainly along the fossil trail, enrich dripping waters with P and N. Their concentrations have also been found at fairly high values across the whole trail network, suggesting an additional potential role of leaching from agricultural and forested soils above the Pertosa‐Auletta Cave in defining dripwater chemistry.
Joint connectivity matrix independent component analysis: Auto‐linking of structural and functional connectivities
Authors: Wu Lei , Calhoun Vince
Published: November 2022

The study of human brain connectivity, including structural connectivity (SC) and functional connectivity (FC), provides insights into the neurophysiological mechanism of brain function and its relationship to human behavior and cognition. Both types of connectivity measurements provide crucial yet complementary information. However, integrating these two modalities into a single framework remains a challenge, because of the differences in their quantitative interdependencies as well as their anatomical representations due to distinctive imaging mechanisms. In this study, we introduced a new method, joint connectivity matrix independent component analysis (cmICA), which provides a data‐driven parcellation and automated‐linking of SC and FC information simultaneously using a joint analysis of functional magnetic resonance imaging (MRI) and diffusion‐weighted MRI data. We showed that these two connectivity modalities produce common cortical segregation, though with various degrees of (dis)similarity. Moreover, we show conjoint FC networks and structural white matter tracts that directly link these cortical parcellations/sources, within one analysis. Overall, data‐driven joint cmICA provides a new approach for integrating or fusing structural connectivity and FC systematically and conveniently, and provides an effective tool for connectivity‐based multimodal data fusion in brain.
Immune repertoire sequencing reveals an abnormal adaptive immune system in COVID‐19 survivors
Authors: Jia Chen , Zhou Zhiguo , Pan Wenjing , Zhang Pan , Yang Ming , Zhao Mingming , Li Bo , Liu Ping , Zhang Qianqian , Kong Xianglong , Li Keyu , Yue Tingting , Cai Ting , Wang Zijun , De Clercq Erik , Li Song , Li Guangdi , Liu Jiyang , Wu Haijing , Lu Qianjin
Published: November 2022

Accumulating evidence suggests that severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) impairs the adaptive immune system during acute infection. Still, it remains largely unclear whether the frequency and functions of T and B cells return to normal after the recovery of Coronavirus Disease 2019 (COVID‐19). Here, we analyzed immune repertoires and SARS‐CoV‐2‐specific neutralization antibodies in a prospective cohort of 40 COVID‐19 survivors with a 6‐month follow‐up after hospital discharge. Immune repertoire sequencing revealed abnormal T‐ and B‐cell expression and function with large T cell receptor/B cell receptor clones, decreased diversity, abnormal class‐switch recombination, and somatic hypermutation. A decreased number of B cells but an increased proportion of CD19+CD138+ B cells were found in COVID‐19 survivors. The proportion of CD4+ T cells, especially circulating follicular helper T (cTfh) cells, was increased, whereas the frequency of CD3+CD4− T cells was decreased. SARS‐CoV‐2‐specific neutralization IgG and IgM antibodies were identified in all survivors, especially those recorded with severe COVID‐19 who showed a higher inhibition rate of neutralization antibodies. All severe cases complained of more than one COVID‐19 sequelae after 6 months of recovery. Overall, our findings indicate that SARS‐CoV‐2‐specific antibodies remain detectable even after 6 months of recovery. Because of their abnormal adaptive immune system with a low number of CD3+CD4− T cells and high susceptibility to infections, COVID‐19 patients might need more time and medical care to fully recover from immune abnormalities and tissue damage.
Factors affecting climate variability of basin‐wide western North Pacific tropical cyclone intensity
Authors: Zhu Yuxiang , Zhao Haikun , Lu Jun , Raga Graciela B. , Duan Jingjing , Wang Chao
Published: November 2022

Changes in the duration of tropical cyclones (TCs) and the embedded large‐scale environment along with TC tracks have a substantial impact on basin‐wide TC intensity. However, their relative importance in changes of basin‐wide TC intensity remains unclear. This study focuses on their contributions to change in TC intensity over the western North Pacific (WNP) basin using a TC intensity model. First, simulations using a TC intensity model with inputs of TC tracks and the embedded environment adequately capture the climate variability of the observed basin‐wide WNP TC intensity. It suggests that the climate variability of basin‐wide TC intensity largely depends on the synergistic changes in large‐scale environment and TC tracks. Sensitivity tests indicated that changes in TC tracks generally appear to be the most important factor affecting basin‐wide TC intensity on the interannual and interdecadal timescales. Changes in large‐scale environment play a limited role especially for weak‐to‐moderate TCs (i.e., tropical storms and Cat.1–3 TCs), while comparable impacts of change in TC tracks and large‐scale environment are found for intense TCs (i.e., Cat.4–5 TCs). Given that TC tracks remain unchanged, sensitivity simulations further show that TC duration plays a more crucial role in controlling basin‐wide TC intensity than the environmental fields. Moreover, weak‐to‐moderate TCs appear to be more sensitive to duration than intense TCs, in consistent with the dramatic changes in basin‐wide TC intensity for westward TCs that form in the South China Sea and the Philippine Sea with short TC duration. Results of this study would be helpful for climate prediction of basin‐wide TC intensity over the WNP basin.
Non‐uniform changes of growing conditions for sweet cherry trees responses to climate warming in main production regions of China
Authors: Sun Wanxia , Ren Ruixuan , Liu Yangtai , Wang Jiyuan , Wang Li , Liu Xunju , Jiu Songtao , Wang Shiping , Zhang Caixi
Published: November 2022

Given the strong sensitivity of sweet cherry trees to air temperature and the foreseeable warming under future climates, it becomes urgent to analyse spatiotemporal variability of growing conditions in main production areas of China. Here, we estimated changes of three climate metrics, that is, winter chill, heat accumulation and the risk of spring frost events, by using 22 global climate models over the historical and future (represented by central years 2050s and 2085s) time stages. Statistically downscaled daily maximum and minimum temperatures at 14 sites under representative concentration pathway (RCP) 4.5 and 8.5 scenarios were used. The results show a general increase of available winter chill for most sites in Bohai and Lanzhou–Lianyungang Railway line agro‐climatic zones, and the increase in chill accumulation could reach up to 15.2% in these regions for RCP4.5 by 2085 s. However, the most dramatic winter chill decrease is projected to occur in the southwest region under the RCP8.5 scenario by 2085 s. Additionally, the increase rate of heat accumulation during the forcing period shows spatially consistency, and the most pronounced increase is found in the RCP8.5 by 2085 s. In the north region, median heat accumulation increases by 17.5%–21.0% in the 2050 s under RCP4.5. Similar increasing range could be found in the southwest station. High frost risk areas are found in the southwestern region for both baseline and future climate scenarios. Across the 14 study sites, Mengzi and Kunming have the highest meteorologically defined risk of spring damaging frost with accumulated 335 growing degree days (GDDs) and 264 GDDs before the last spring frost event, respectively. Overall, this study provides projected characteristics of site‐specific growing conditions for sweet cherry trees in main production regions. The results could be useful for decision‐making such as selection of appropriate species and varieties in adapting to future warming.
Extraction of anthocyanins from haskap using cold plasma‐assisted enzyme
Authors: Zhou Yajun , Li Jiangfei , Li Zongping , Ma Qingshu , Wang Lu
Published: November 2022

BACKGROUND

Haskap berries (Lonicera caerulea L.) are rich in anthocyanins. Cold plasma‐assisted enzyme method (CPEM) is an innovative method for green extraction of anthocyanins, which was optimized by an artificial neural network‐genetic algorithm (ANN‐GA) to maximize the yield. In this study, seven factors were screened using by Plackett–Burman design based on single‐factor experiments and optimized by ANN‐GA.

RESULTS

The results showed that the maximum total anthocyanin content (TAC, 42.45 ± 0.25 g cyanidin‐3‐glucoside equivalent (C3G) kg−1 dry weight, DW) was obtained under optimal pretreatment power of 192 W, pretreatment time of 29 s and liquid‐to‐solid ratio of 39 mL g−1. Cleavage and porosity appeared on the surface of the treated sample. The active ingredients and antioxidant capacity of the CPEM extracts were identified by ultra‐performance liquid chromatography with quadrupole time‐of‐flight mass spectrometry (UPLC‐Q‐TOF‐MS). Compared with other extraction technologies, CPEM presents the advantages of shortening the extraction time, reducing the solvent volume, and significantly increasing active ingredients and antioxidant activity.

CONCLUSION

The ANN‐GA has better predictive and higher accuracy than the response surface methodology (RSM) model and is more suitable for optimizing the CPEM by greatly improving the process yield and the utilization of biomass, thus contributing to the sustainability of the agri‐food chain. © 2022 Society of Chemical Industry.
An equal 18‐way low‐profile power divider for sparse antenna arrays using amplitude equalization network
Authors: Zhou Yedi , Song Kaijun , Guo Song , Yong Fan
Published: November 2022

An equal 18‐way power divider, using a half‐air‐filled stripline technique, is presented in this letter. An amplitude equalization network is designed to mitigate the amplitude imbalance of the multiplexed planar/quasi‐planar power‐division network. Optimized transmission paths are obtained based on a combination of 1‐6‐3 power division and a multilayer structure, which effectively reducing transmission losses. To validate the design, this power divider, which is used to feed a sparse antenna array, is designed, optimized, fabricated, and measured. The measured return loss was better than 18 dB, and the measured insertion loss was better than 1.55 dB over the range 7–10 GHz. The amplitude imbalance is better than 0.4 dB, and the phase imbalance is better than 7.3°. The measured results are in good agreement with the simulation results.
Arterial spin labeling using spatio‐temporal encoding readout for robust perfusion imaging in inhomogenous magnetic fields
Authors: Franklin Suzanne L. , Schuurmans Megan , Otikovs Martins , Borman Pim T. S. , van Osch Matthias J. P. , Bos Clemens
Published: November 2022

Purpose

To evaluate the feasibility of spatio‐temporal encoding (SPEN) readout for pseudo‐continuous ASL (pCASL) in brain, and its robustness to susceptibility artifacts as introduced by aneurysm clips.

Methods

A 2D self‐refocused T2*‐compensated hybrid SPEN scheme, with super‐resolution reconstruction was implemented on a 1.5T Philips system.Q(=BWchirp*Tchirp) was varied and, the aneurysm clip‐induced artifact was evaluated in phantom (label‐images) as well as in vivo (perfusion‐weighted signal (PWS)‐maps and temporal SNR (tSNR)). In vivo results were compared to gradient‐echo EPI (GE‐EPI) and spin‐echo EPI (SE‐EPI). The dependence of tSNR on TR was evaluated separately for SPEN and SE‐EPI. SPEN withQ ˜ 75 encodes with the same off‐resonance robustness as EPI.

Results

The clip‐induced artifact with SPEN decreased with increase in Q, and was smaller compared to SE‐EPI and GE‐EPI in vivo. tSNR decreased with Q and the tSNR of GE‐EPI and SE‐EPI corresponded to SPEN with a Q‐value of approximately ˜85 and ˜108, respectively. In addition, SPEN perfusion images showed a higher tSNR (p < 0.05) for TR = 4000 ms compared to TR = 2100 ms, while SE‐EPI did not. tSNR remained relatively stable when the time between SPEN‐excitation and start of the next labeling‐module was more than ˜1000 ms.

Conclusion

Feasibility of combining SPEN with pCASL imaging was demonstrated, enabling cerebral perfusion measurements with a higher robustness to field inhomogeneity (Q > 75) compared to SE‐EPI and GE‐EPI. However, the SPEN chirp‐pulse saturates incoming blood, thereby reducing pCASL labeling efficiency of the next acquisition for short TRs. Future developments are needed to enable 3D scanning.
Preliminary analysis of hippocampus synaptic apoptosis and microglial phagocytosis induced by severe restraint stress
Authors: Enomoto Shingo , Ohgidani Masahiro , Sagata Noriaki , Inamine Shogo , Kato Takahiro A.
Published: November 2022

Aim

Several studies reported stress‐induced microglial phagocytosis, but the biochemical mechanisms by which stress alters microglial synaptic phagocytosis are not fully uncovered. Local or limited apoptosis without cell death was observed at neuronal synapses in previous studies, and proposed as an upstream mechanism for microglial synapse elimination. In this micro‐report, we aimed to preliminary examine local synaptic apoptosis in the mouse hippocampus following severe restraint stress, and its effect on microglial phagocytosis.

Methods

Mice were exposed to 10‐day water immersion restraint stress (WIRS). Brain sections including stratum lucidum in the hippocampal CA3 subfield were stained with antibodies against cleaved caspase 3, ionized calcium‐binding adapter molecule1 (Iba1), lysosomal‐associated membrane protein1 (LAMP1), vesicular glutamate transporter1 (VGLUT1). Co‐localization among these proteins were calculated.

Results

Our image analysis revealed that synaptic apoptosis was increased while there were no significant changes in microglial phagocytic activity and synaptic phagocytosis following 10‐day WIRS.

Conclusion

Severe restraint stress enhanced pre‐synaptic apoptosis in mouse CA3 stratum lucidum region, but did not promote microglial phagocytosis. The phenomenon microglia fail to phagocytose weakened and unnecessary synapses may be related to pathology of stress.