bluuebunny/crossref_metadata_2025 huggingface dataset:
Research data management and services: Resources for novice data librarians
Authors: Barbrow Sarah , Brush Denise , Goldman Julie
Published: June 2017

Research in many academic fields today generates large amounts of data. These data not only must be processed and analyzed by the researchers, but also managed throughout the data life cycle. Recently, some academic libraries have begun to offer research data management (RDM) services to their communities. Often, this service starts with helping faculty write data management plans, now required by many federal granting agencies. Libraries with more developed services may work with researchers as they decide how to archive and share data once the grant work is complete.
TEACHING FROM THE ARCHIVES
Authors: Falbo Bianca
Published: June 2017

My first thoughts in response to the question “What’s so special about special collections¿̣” were in relation to my own experience researching and writing about nineteenth-century Anglo-American literature and print culture. But like a lot of teachers, I find that my research informs my classroom practice and that my classroom practice, in turn, reinvigorates my research. Consequently, much of my thinking about this question comes out of my experience designing archival research projects for my undergraduate students. So, in response to why, at a time of increasingly sophisticated electronic resources for “preserving” and making available special collections materials, we should . . .
IS THERE A FUTURE FOR SPECIAL COLLECTIONS? AND SHOULD THERE BE?: A POLEMICAL ESSAY
Authors: Traister Daniel
Published: June 2017

Of the holy trinity—collecting, preserving, and making accessible precious books, manuscripts, and other special materials—preservation takes precedence.1
Following are three brief prefatory notes that will be helpful in understanding this essay. First, readers should note that the word polemical appears in the essay’s title. I ask the reader’s indulgence in understanding that I mean this word literally. The essay is a polemic. Intended to be serious, it is not therefore also intended to be “balanced” or “fair.” In addition, it is an essay, not a paper; and its informality of style is intended to reflect a difference between these two . . .
Guest Editor’s Note
Authors: Overholt John
Published: June 2017

This issue presents a selection of papers from the 51st RBMS Preconference, entitled Join or Die: Collaboration in Special Collections. From the beginning, the intention of the preconference planners was to reflect that theme not just in the substance of the programming but in the structure of the conference itself, with a schedule that emphasized more diverse and interactive forms of programming. That idea has been carried through to this special issue—three of the four articles were originally presented as part of seminars. I am grateful to the authors for their willingness to go beyond the already considerable effort . . .
Bridging the Gap: Taking Practical Steps Toward Managing Born-Digital Collections in Manuscript Repositories
Authors: Goldman Ben
Published: June 2017

A few years ago I attended a lecture by a well-known digital libraries researcher who, when discussing the issue of digital preservation, clicked forward to a PowerPoint slide that included Pablo Picasso’s iconic ink illustration of Don Quixote, the placement of which seemed a little too conveniently symbolic to be accidental. Regardless of the presenter’s intent, it is clear that the quest for sound and simple processes to support the management and preservation of electronic records—now often referred to as “born-digital” records—has remained a Quixotic one for many manuscripts curators and archivists, even more than two decades into . . .
Education, Training, and Recruitment of Special Collections Librarians: An Analysis of Job Advertisements
Authors: Hansen Kelli
Published: June 2017

This study surveys special collections job advertisements that are appropriate for recent graduates of LIS programs to determine the positions’ core qualifications and duties in relationship to the relatively recent set of core competencies identified by the Rare Book and Manuscripts Section (RBMS) of the Association of College and Research Libraries (ACRL). Rather than tracing the development of the position or identifying changes and trends, the study assembles a composite image of the opportunities available to new graduates, and the qualifications and competencies in demand by employers, over a five-year period. Although this is an exploratory survey, it is hoped . . .
Bettina Wagner and Marcia Reed, eds. Early Printed Books as Material Objects. Berlin: De Gruyter Saur, 2010. xii, 367p. ISBN 9783110253245. $150.00.
Authors: Sheehan Jennifer K.
Published: June 2017

This book consists of the proceedings from a preconference organized by the Rare Books and Manuscripts Section of the International Federation of Library Associations and Institutions (IFLA), held in Munich 19–21 August 2009 as a satellite meeting to IFLA’s annual congress in Milan, Italy. In the Introduction, Wagner sets the stage for the work included in this collection of presented papers. Although multiple copies of early printed editions may survive to the present day, Wagner emphasizes the importance of early printed books as individual objects, each with unique characteristics that distinguish it from all other copies printed in the . . .
The Practice, Power, and Promise of Archival Collections Assessment
Authors: Conway Martha O’Hara , Proffitt Merrilee
Published: June 2017

In the ongoing transition from institution-centered collections to a user-centered world of networked information, the role of the research library has changed dramatically. “Rather than focusing on acquiring the products of scholarship,” a recent ARL issue brief noted, “the library is now an engaged agent supporting and embedded within the processes of scholarship.”1 Successful collection management in this new environment has become a juggling act requiring careful consideration of a number of factors including the proliferation of shared print repositories, the shift to patron-driven acquisitions, the role of digital surrogates in discovery and use, and the importance of redirecting effort . . .
Data-Driven Management and Interoperable Metrics for Special Collections and Archives User Services
Authors: Chapman Joyce , Yakel Elizabeth
Published: June 2017

While special collections and archives managers have at times recognized the importance of using data to drive decision making, translating this objective into reality and integrating data analysis into day-to-day operations has proven to be a significant challenge. There have also been obstacles to formulating quantitative metrics for special collections and archives and rendering them interoperable across institutional boundaries. This article attempts to focus a conversation around two issues: 1) the importance of quantitative analysis of operational data for improving research services in special collections and archives; and 2) the need for the profession to achieve consensus on definitions for . . .
Karen Nipps. Lydia Bailey: A Checklist of Her Imprints. University Park, Pa.: The Pennsylvania State University for the Bibliographical Society of America in association with the Houghton Library, Harvard University, and the Library Company of Philadelphia, 2013. xiii + 310 p. $79.95 (ISBN: 978-0-271-05571-8).
Authors: Solek Vivian Lea
Published: June 2017

From a review of the earlier published scholarship in the field of printing history, an inquiring reader would surmise that women were not a significant part of commercial letterpress printing during the handpress period. Scholarship in the last 20 years, however, has revealed that this is not the case. In fact, many recent studies document women’s high degree of involvement from the earliest days of printing in the Western world.Lydia Bailey: A Checklist of Her Imprints is an important addition to the study of the history of the book and of women’s roles in letterpress printing. It is a . . .
Embracing the Future as Stewards of the Past: Charting a Course Forward for Historical Medical Libraries and Archives
Authors: Reznick Jeffrey S.
Published: June 2017

In June 2013, the American Academy of Arts and Sciences (AAAS) released The Heart of the Matter, a report on the continuing indispensable role of the humanities and social sciences in meeting major global challenges and urgent national goals. Commissioned by a bipartisan group of senators and representatives and involving more than fifty AAAS members from various sectors—including academia, business, government, the arts, and the media—the report called for renewed commitment to the humanities and social sciences. More specifically, it called for leadership collaborations across a wide array of sectors to meet the urgent goals of: educating Americans . . .
Donald C. O’Brien. The Engraving Trade in Early Cincinnati. Athens: Ohio University Press, 2013. ix, 194 p. ISBN 978-0821420140. $29.14
Authors: Dean Jason W.
Published: June 2017

Donald C. O’Brien’s The Engraving Trade in Early Cincinnati is the first published survey of individuals and businesses engaged in engraving, lithographing, and printing in early Cincinnati, Ohio. Mr. O’Brien, a retired public educator, is a past president of the American Historical Print Society and a member of the American Antiquarian Society. This title highlights the work of early engravers and printers in Cincinnati in the wider context of American engraving and illustration, while also giving an overview of notable items and titles produced by these firms. O’Brien gives a roughly chronological look at the firms and their work in . . .
Editor's Note
Authors: Sheehan Jennifer K.
Published: June 2017

After the 30th anniversary “digital vs. physical” issue in the Spring, we didn’t set out to have a theme for this one. There is no link between any two articles in this issue, beyond their relationship to special collections. Many of our peers are doing such interesting work and scholarship, covering a spectrum of activities related to our discipline, that we didn’t want to restrict the types of submissions we received. When I say “spectrum,” that’s precisely what these articles offer—illumination of the world of special collections, from the precise to the infinite, viewed through the lens of these authors.
In the Flesh? Anthropodermic Bibliopegy Verification and Its Implications
Authors: Gordon Jacob
Published: June 2017

Special collections hold a host of objects that lie outside the anticipated disintegrating newsprint or leather-bound tomes. Sometimes the items, at least as far as their provenance informs, appear to be rather abnormal. Within the Cassel Collection, held at Beeghly Library at Juniata College, was one such volume: Bibliotheca Politica. Abraham H. Cassel (1820–1908) collected widely during his lifetime, amassing a collection of 50,000 volumes. On the front flyleaf of Bibliotheca Politica, Cassel wrote: “This book [is] bound in human skin.” As will be seen, this is not a unique notation, nor is it unusual for such an inscription to be the only bit of information to suggest the binding material. Subsequent peptide mass fingerprinting of samples taken from the binding of Bibliotheca Politica proved it to be made of sheepskin. While this result led to a mingled sense of disappointment and relief, it did spark the author’s curiosity into this historical binding practice.
A Constructivist Approach for Introducing Undergraduate Students to Special Collections and Archival Research
Authors: Vong Silvia
Published: June 2017

In the last five years, a wealth of literature has been published on collaborations and practical approaches to engaging undergraduate students with special collections and archival materials. However, there is a gap in the literature on pedagogical approaches to teaching undergraduates with special collections. Constructivism, a learning theory, centers on the idea that students are able to construct their own meaning from their learning environment and experiences with guidance from a teacher, and that students possess prior knowledge from their own experiences. Prior knowledge helps to connect students to new knowledge with support from the teacher. Rather than create a learning environment that treats students as passive learners with nothing to contribute, the constructivist approach involves students in the learning process by engaging them in dialogue with the teacher and their peers, situating them through hands-on practice and helping them develop an awareness of their own learning preferences and experiences. The constructivist learning theory acts as a guide for designing lesson plans and activities.
THE HARD WORK OF SOFTWARE HISTORY
Authors: Lowood Henry
Published: June 2017

A few years ago, the literary and media historian Friedrich Kittler opened an essay called “There Is No Software” with, in his own words, a “rather sad statement.” In his view, “the bulk of written texts—including this text—do not exist anymore in perceivable time and space but in a computer memory’s transistor cells.” From a scholar who, until then, had situated the cultural meaning of literary texts in discourse networks dependent on technologies of inscription (writing, gramophone, typewriter, computer) and the materiality of communication, this remark captures the essence of a significant cultural shift. At the end of the twentieth . . .
EDITOR'S NOTE
Authors: Browar Lisa
Published: June 2017

“No day but today.” The cast of the long-running musical Rent sings this anthem of consolation at the end of Act Two before sending its audience out into the neon-saturated day-for-night world that is Times Square after dark. After a modest beginning composer Jonathan Larson's Pulitzer prize-winning work about the lives and loves of starving artists inhabiting abandoned buildings made its way uptown from an authentically grungy theatre in New York City's East Village to the posh Nederlander Theatre. Newly refurbished, the better to emulate a shabby downtown performance space, the Nederlander evokes for upmarket audiences the downmarket and . . .
EVIDENCE: TOWARD A LIBRARY DEFINITION OF EPHEMERA
Authors: Young Timothy G.
Published: June 2017

In her book Evidence: The Art of Candy Jernigan, the artist works with a palette of what might be called detritus: sketches of crushed cans, cigarette packages, and burnt matches coreside with real bottle caps, crack vials, and even a stuffed rat, all of which form the substance of her work. This obsession with the rejected also is found in her travel journals, pages of which are reproduced in facsimile in the book. In these records of her travels across the United States and around the world, Jernigan ups the ante for the standard travelogue by pasting in cobwebs from . . .
INTERVIEW WITH ROGER E. STODDARD
Authors: Slive Daniel J.
Published: June 2017

Roger E. Stoddard will retire in December 2004 as Curator of Rare Books in the Harvard College Library after four decades of service in the Houghton Library. To commemorate this event, Stoddard curated an exhibition in Spring 2004 titled “RES Gestae: Libri Manent: A Curator’s Choice of Books Purchased for the Houghton Library from 1965 to 2003,” which explored many of the collecting areas he pursued at Harvard. Acquisitions for Historical Collections, a symposium in the curator’s honor, was also held at Harvard in March 2004.1
Born and raised in New England, Stoddard attended Brown University and received his bachelor’s . . .
RARE CONDITION: PRESERVATION ASSESSMENT FOR RARE BOOK COLLECTIONS
Authors: Starmer Mary Ellen , McGough Sara Hyder , Leverette Aimée
Published: June 2017

It is not uncommon for a university to house its special collections library in the “old” library building. The character of the architecture and the connection with the university’s past often fit with the mission of collecting and preserving rare books, manuscripts, and university archives. A beautiful old library can inspire both librarians and researchers. However, it also can be the downfall of the very collections we treasure. Many older libraries now housing rare and valuable special collections materials have out-of-date and inadequate environmental control systems, if they have any at all. The resulting environmental conditions, particularly wide fluctuations in . . .
THE SALA DE INVESTIGACIONES —FONDO RESERVADO OF THE UNIVERSITY OF SAN MARCOS CENTRAL LIBRARY, LIMA, PERU
Authors: Nehmad Alberto Loza
Published: June 2017

The Universidad Nacional Mayor de San Marcos (UNMSM) was founded in 1551 in Lima, Peru, and for centuries has remained the major university in the country. But during the past several decades, a number of other universities, both public and private, have been created in Lima, and San Marcos now shares with them a space that, until the mid-twentieth century, was almost exclusively its own. Today, the rare book and manuscript collections within the library system are among the most important in the country. A recent development has been the creation of the Sala de Investigaciones Bibliográficas-Fondo Reservado,1 which contains . . .
From “Treasure Room” to “School Room”: Special Collections and Education
Authors: Smith Steven Escar
Published: June 2017

Webster's Ninth New Collegiate Dictionary states that education involves learning and then defines learning as the acquisition of knowledge or understanding through study, instruction, or experience.1 This is the best and broadest definition of the term I know of and the one that most closely informs what I do in my work as director of the Cushing Memorial Library and Archives at Texas A&M University. I consider any activity that provides opportunities for study or experience as education. In a special collections environment, this includes traditional classroom teaching as well as many other undertakings—exhibits, displays, guided and self-guided tours, . . .
Education and Training of Special Collections Professionals, Librarians, and Archivists in Canada
Authors: Fleming Patricia
Published: June 2017

I would like to open with two recent national events. The first concerns Library and Archives Canada/Bibliothèque et Archives Canada (LAC/BAC), a new institution created by federal legislation proclaimed on May 21, 2004, in a merger of the National Archives and the National Library. The National Archives was the older of the two entities. Established in 1872, it was the first cultural agency created after Confederation in 1867. An active collector from the outset, the Archives maintained offices in London and Paris, collected documentary art, photographs, and artifacts (including war trophies during the First World War), as well as books . . .
Protocols for Native American Archival Materials
Authors: Underhill Karen J.
Published: June 2017

In the midst of a spring snowstorm on April 5, 2006, a group of fifteen Native American, First Nation, and Aboriginal information professionals and scholars and four non-Native archivists gathered at the Northern Arizona University Cline Library (Flagstaff, Arizona) for a series of conversations.1 The goal of this invitational conference was to develop best practices for culturally responsive care and use of American Indian archival material held by non-tribal organizations. The participants tackled complex topics, such as the intersection of Native American and Western knowledge systems, to produce a draft document entitled Protocols for Native American Archival Materials. Written from . . .
Intersecting Missions, Converging Practice
Authors: Martin Robert S.
Published: June 2017

I am especially pleased to have been asked to contribute to this issue of RBM, focusing as it does on the convergence of libraries, museums, and archives. This has been a major interest of mine for a long time, and almost all of my professional experience has been within institutions housing collections comprising not only rare books and other library materials, but also incorporating rich assemblages of institutional archives, historical and literary manuscripts, maps, prints, photographs, oral history resources, works of art, and artifacts.
As Director of the Institute of Museum and Library Services (IMLS), I found myself in a . . .
Introduction
Authors: Welbourne Penny , Burns Kathleen T.
Published: June 2017

The Fall 2003 issue of RBM included an article entitled “RBMS, Special Collections, and the Challenge of Diversity: The Road to the Diversity Action Plan” by Julie Grob, Chair of the RBMS Task Force on Diversity. In it she stated, “Since its debut in 1986, neither RBM nor RBML [Rare Books and Manuscript Librarianship, the predecessor to RBM] has ever published a single article on racial and ethnic collections, despite awareness of the lack of diversity in the section and the occurrence of pre-conference sessions on ethnic collections … Marvin Taylor (RBM co-editor, 2000–2003) says that the editorial board . . .
John Dewey y la tragedia de los Comunes
Authors: Esteban  Cloquell José Miguel
Published: June 2017

s de participación democrática contenidos en la obra de John Dewey posibilitan comunidades de aprendizaje e investigación que comparten los procesos comunicativos  que Ostrom (1990) señala como condiciones de cooperación frente a algunos de los dilemas sociales  que la crisis ambiental plantea a las sociedades contemporáneas.  Se analizarán la Investigación de Acción (Action Research) y (2) como heurística basadas en esos conceptos, para mostrar finalmente que ambas   comparten  una noción de racionalidad ambiental  sustentada en la interdependencia entre las nociones de validez ecológica y validez social
Lo sublime kantiano como paradoja. A propósito de un ejemplo de Jean-Luc Marion
Authors: Llorente Cardo Jaime
Published: June 2017

Partiendo de un ejemplo mencionado por Jean-Luc Marion, el presente trabajo trata de desarrollar y explicitar las conexiones entre la teoría del “fenómeno saturado” o “paradoja” expuesta por el fenomenólogo francés y la descripción del fenómeno de lo sublime que Kant ofrece fundamentalmente en su Crítica del juicio. A este respecto, se examinan los cuatro puntos de vista o categorías que permiten reconocer un determinado fenómeno como “saturado” o “paradójico” (invisable, insupportable, absolu e irregardable) a la luz del modo en el cual Kant aborda la cuestión de la exposición perceptiva a un elemento definido por la sublimidad. Tal análisis permite acaso arrojar alguna luz sobre el sentido del renacimiento “popular” de la estética de lo sublime que puede apreciarse en múltiples aspectos de la cultura contemporánea.
Código técnico y Situación hermenéutica
Authors: Mascaró Luciano
Published: June 2017

El presente trabajo se propone estudiar la obra de Andrew Feenberg «Transforming Technology» para mostrar que la allí desarrollada presentación de Heidegger como representante de la así llamada «Teoría sustantiva de la tecnología” responde a la preferente consideración de las obras posteriores a la «Kehre» de los años ’30. En contraste, consideramos que la filosofía del primer período del pensar de Heidegger posee numerosos puntos de contacto con la posición propuesta por Feenberg, la así llamada «Teoría crítica de la tecnología». En esta línea, nos ocuparemos de hacer explícita una de las posibles articulaciones: propondremos que en la noción de «Código técnico» de Andrew Feenberg puede encontrarse una fuerte resonancia de la idea de mundo de Heidegger; por esta vía buscamos rescatar la figura del autor alemán como la de un defensor, o al menos, un antecedente de la teoría crítica de la tecnología
Evaluation of risk management tools for stabilising farm income under CAP 2014-2020
Authors: Castañeda-Vera Alba , Garrido Alberto
Published: June 2017

Guaranteeing farm income stability is an objective of the European Union’s and the Spanish agricultural policies. In this paper, CAP direct payments, diversification, crop insurance and an Income Stabilisation Tool (IST) were compared considering (i) their effect on farm income and income stability, (ii) the expected farmers’ willingness for adoption, and (iii) the efficiency of public expenditure invested in supporting them. Main conclusions point at direct payments and  crop diversification as the most effective measures in decreasing income variability. Nevertheless, using crop  insurance or an IST has potential for both improving farm resilience to income variability and limiting public expenditure.
Walter Benjamin liest Georg Simmel. Über Walter Benjamin und Georg Simmel von Marian Mičko
Authors: Barbisan Léa
Published: June 2017

Marian Mičko’s book Walter Benjamin und Georg Simmel (2010) gives a precise insight into Benjamin’s debt towards Simmel’s philosophical method and characterization of modern experience. Centered on the similarities between their “phenomenology of modernity”, Mičko’s analysis widely disregards the discrepancies between Simmel’s and Benjamin’s assessments of modern experience, culminating in Benjamin’s criticism of the bourgeois concept of individuality and his commitment to a Marxist approach.
Review of the Third International Symposium on Georg Simmel - Medellín, Colombia. November 2011
Authors: Cervantes Reyes Haydeé Lorena , Botia Merchán H. Augusto , Díaz Aldana Gilberto , Mosquera Acevedo Einer
Published: June 2017

The University of Antioquia in Medellín, Colombia, was the scenario for holding what can be regarded now as a tradition in Latin America: an International Symposium on Georg Simmel. This review attempts to share the result of the third symposium outlining how simmelian categories were revisited and used as research keys for understanding the Latin American context. It is worth to mention that after the event not only the initiative of publishing the proceedings was achieved, but also the formalization of a Latin American simmelian studies network. This valuable experience of gathering around Simmel’s work will return to its initial point when the Fourth Symposium will be hold in Buenos Aires, Argentina, on November 2015.
Metodologias ativas: das concepções às práticas em distintos níveis de ensino
Authors: Valente José Armando , Bianconcini de Almeida Maria Elizabeth , Flogi Serpa Geraldini Alexandra
Published: June 2017

Este artigo foi desenvolvido com base no trabalho realizado a partir da disciplina Currículo, Tecnologias, Aprendizagem e os Desafios à Educação na Cultura Digital, ministrada durante o segundo semestre de 2016, no Programa de Pós-graduação em Educação: Currículo, da Pontifícia Universidade Católica de São Paulo (PUC-SP). Essa disciplina tinha como objetivo desenvolver práticas que explorassem o uso das Tecnologias Digitais de Informação e Comunicação (TDIC) e estudar as contribuições e limites que tais práticas oferecem ao desenvolvimento do currículo e à aprendizagem baseada nas metodologias ativas. Oito estudantes de mestrado e doutorado participaram dela e, como parte das atividades, cada um desenvolveu uma prática pedagógica com alunos do ensino básico ou superior, baseada em metodologias ativas com o uso das TDIC. Como produto dessa experiência, cada estudante produziu um texto reflexivo e uma narrativa digital, representando o processo de aprendizagem ao longo da disciplina. Os resultados do trabalho possibilitaram entender as diferentes concepções sobre metodologias ativas, bem como analisar as potencialidades destas metodologias para uso em diferentes níveis de ensino.
Analytic Hierachy Process suportando a avaliação por pares
Authors: Wollmann Dewey
Published: June 2017

A avaliação pode ser um importante instrumento para complementar o processo de aprendizagem, principalmente quando se deseja desenvolver, em complemento ao conteúdo técnico, habilidades humanas, como é o caso dos estudantes dos cursos de Administração. Nesse contexto, a utilização de técnicas de metodologias ativas e de avaliação por pares merece destaque. O objetivo deste estudo é avaliar o uso da técnica de análise multicritérios denominada analytic hierarchy process para auxiliar a avaliação por pares. A ferramenta desenvolvida foi utilizada em um exemplo hipotético, com características de uma disciplina do curso de Administração de Empresas. O estudo, de modelagem quantitativa, foi desenvolvido segundo os modelos de Bertrand e Fransoo (2002) e Mitroff et al. (1974). Como resultado, foi possível identificar que a técnica permite, a partir de critérios predefinidos e hierarquizados, identificar os graus de desempenho dos estudantes de uma equipe de trabalho. Com essas informações, o feedback para os estudantes torna-se mais objetivo e efetivo.
Structural Changes in the Lower Extremities in Boys Aged 7 to 12 Years Who Engage in Moderate Physical Activity
Authors: Gijon-Nogueron Gabriel , Diaz-Miguel Salvador , Lopezosa-Reca Eva , Cervera-Marin Jose Antonio
Published: June 2017

Background:

Physical activity in children may provide health benefits. We sought to consider the practice of soccer as a possible major factor in the development of the lower limb. The study is based on 3-year data for a group of children who practice this sport.

Methods:

For 3 years we monitored 53 children who practiced soccer 3 times a week and had engaged in 2 years of continuous sports activity. Their mean ± SD age was 8.49 ± 2.01 years in the first year. Each year, Foot Posture Index, valgus index, subtalar joint axis, and Q angle for the knee were analyzed.

Results:

The mean ± SD Foot Posture Index scores ranged from 5.38 ± 1.79 in the right foot and 4.49 ± 1.67 in the left foot in the first year to 4.64 ± 2.51 and 4.34 ± 2.26, respectively, in the third year. The valgus index for the same period ranged from 14.05° ± 1.51° (right) and 13.88° ± 1.46° (left) to 13.09° ± 1.28° and 13.07° ± 1.07°, respectively. In the knee, the Q angle ranged from 12.83° ± 1.98° (right) and 12.74° ± 1.68° (left) to 13.17° ± 1.45° and 13.26° ± 1.46°, respectively. In the subtalar joint, the changes were 37.73% right and 30.19% left between the first and third years toward a neutral subtalar joint axis.

Conclusions:

These results show that although playing soccer might cause structural changes in the lower limb, these alterations should not be considered harmful because they may be influenced by age as well.
LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs
Authors: Hong Sungki , Freeberg Mallory A , Han Ting , Kamath Avani , Yao Yao , Fukuda Tomoko , Suzuki Tsukasa , Kim John K , Inoki Ken
Published: June 2017

The RNA binding protein, LARP1, has been proposed to function downstream of mTORC1 to regulate the translation of 5’TOP mRNAs such as those encoding ribosome proteins (RP). However, the roles of LARP1 in the translation of 5’TOP mRNAs are controversial and its regulatory roles in mTORC1-mediated translation remain unclear. Here we show that LARP1 is a direct substrate of mTORC1 and Akt/S6K1. Deep sequencing of LARP1-bound mRNAs reveal that non-phosphorylated LARP1 interacts with both 5’ and 3’UTRs of RP mRNAs and inhibits their translation. Importantly, phosphorylation of LARP1 by mTORC1 and Akt/S6K1 dissociates it from 5’UTRs and relieves its inhibitory activity on RP mRNA translation. Concomitantly, phosphorylated LARP1 scaffolds mTORC1 on the 3’UTRs of translationally-competent RP mRNAs to facilitate mTORC1-dependent induction of translation initiation. Thus, in response to cellular mTOR activity, LARP1 serves as a phosphorylation-sensitive molecular switch for turning off or on RP mRNA translation and subsequent ribosome biogenesis.
Somatostatin binds to the human amyloid β peptide and favors the formation of distinct oligomers
Authors: Wang Hansen , Muiznieks Lisa D , Ghosh Punam , Williams Declan , Solarski Michael , Fang Andrew , Ruiz-Riquelme Alejandro , Pomès Régis , Watts Joel C , Chakrabartty Avi , Wille Holger , Sharpe Simon , Schmitt-Ulms Gerold
Published: June 2017

The amyloid β peptide (Aβ) is a key player in the etiology of Alzheimer disease (AD), yet a systematic investigation of its molecular interactions has not been reported. Here we identified by quantitative mass spectrometry proteins in human brain extract that bind to oligomeric Aβ1-42 (oAβ1-42) and/or monomeric Aβ1-42 (mAβ1-42) baits. Remarkably, the cyclic neuroendocrine peptide somatostatin-14 (SST14) was observed to be the most selectively enriched oAβ1-42 binder. The binding interface comprises a central tryptophan within SST14 and the N-terminus of Aβ1-42. The presence of SST14 inhibited Aβ aggregation and masked the ability of several antibodies to detect Aβ. Notably, Aβ1-42, but not Aβ1-40, formed in the presence of SST14 oligomeric assemblies of 50 to 60 kDa that were visualized by gel electrophoresis, nanoparticle tracking analysis and electron microscopy. These findings may be relevant for Aβ-directed diagnostics and may signify a role of SST14 in the etiology of AD.
Pathological game use in adults with and without Autism Spectrum Disorder
Authors: Engelhardt Christopher R. , Mazurek Micah O. , Hilgard Joseph
Published: June 2017

This study tested whether adults with autism spectrum disorder (ASD) are at higher risk for pathological game use than typically developing (TD) adults. Participants included 119 adults with and without ASD. Participants completed measures assessing daily hours of video game use, percent of free time spent playing video games, and symptoms of pathological game use. The results indicated that adults with ASD endorsed more symptoms of video game pathology than did TD adults. This relationship was strong, enjoying 300,000-to-1 odds in Bayesian model comparison. Results also showed that adults with ASD spent more daily hours playing video games and spent a higher percent of their free time playing video games than did TD adults. Even after adjustment for these differences in daily video game hours and proportion of free time spent on games, model comparisons found evidence for a difference in game pathology scores associated with ASD status. Additionally, escapism motives for playing video games was associated with game pathology scores in both ASD and TD adults, replicating and extending a previous report. In conclusion, the risk for pathological game use appears larger in adults with ASD compared with TD adults. These findings point to pathological game use as a potentially important focus of clinical attention in adults with ASD.
Reconstitution of Low‐Density Lipoproteins with Fatty Acids for the Targeted Delivery of Drugs into Cancer Cells
Authors: Zhu Chunlei , Pradhan Pallab , Huo Da , Xue Jiajia , Shen Song , Roy Krishnendu , Xia Younan
Published: June 2017

Low‐density lipoproteins (LDLs) are a class of nanocarriers for the targeted delivery of therapeutics into aberrant cells that overexpress the LDL receptor. A facile procedure is used for reconstituting the hydrophobic core of LDLs with a binary fatty acid mixture. Facilitated by the tumor targeting capability of the apolipoprotein, the reconstituted, drug‐loaded LDLs can effectively target cancer cells that overexpress the LDL receptor while showing minor adverse impact on normal fibroblasts. According to a hypothesized mechanism, the reconstituted LDLs can also enable metabolism‐triggered drug release while preventing the payloads from lysosomal degradation. This study demonstrates that LDLs reconstructed with fatty acids hold great promise to serve as effective and versatile nanocarriers for targeted cancer therapy.
Palladium‐Catalyzed Fluoroarylation of gem‐Difluoroalkenes
Authors: Tang Hai‐Jun , Lin Ling‐Zhi , Feng Chao , Loh Teck‐Peng
Published: June 2017

A Pd‐catalyzed fluoroarylation of gem‐difluoroalkenes with aryl halides is reported. By taking advantage of the in situ generated α‐CF3‐benzylsilver intermediates derived from the nucleophilic addition of silver fluoride to gem‐difluoroalkenes, this strategy bypasses the use of a strong base, thus enabling a mild and general synthetic method for ready access to non‐symmetric α,α‐disubstituted trifluoroethane derivatives.
A dual‐fluorescence reporter in the Eomes locus for live imaging and medium‐term lineage tracing
Authors: Probst Simone , Daza Ray A. , Bader Natalie , Hummel Jonas F. , Weiß Matthias , Tanriver Yakup , Hevner Robert F. , Arnold Sebastian J.
Published: June 2017

The T‐box transcription factor Eomes (also known as Tbr2) shows short‐lived expression in various localized domains of the embryo, including epiblast cells during gastrulation and intermediate progenitor cells in the cerebral cortex. In these tissues Eomes fulfills crucial roles for lineage specification of progenitors. To directly observe Eomes‐dependent cell lineages in the living embryo, we generated a novel dual‐fluorescence reporter allele that expresses a membrane‐bound tdTomato protein for investigation of cell morphology and a nuclear GFP for cell tracing. This allele recapitulates endogenous EOMES protein expression and is suitable for live imaging. We found that the allele can also be used as a short‐to‐medium‐term lineage tracer, as GFP persists in cells longer than EOMES protein and marks Eomes‐dependent lineages with a timeframe of days to weeks depending on the proliferation rate. In summary, we present a novel genetic tool for investigation of Eomes‐dependent cell types by live imaging and lineage tracing.
Prediction in ecology: a first‐principles framework
Authors: Dietze Michael C.
Published: June 2017

Quantitative predictions are ubiquitous in ecology, yet there is limited discussion on the nature of prediction in this field. Herein I derive a general quantitative framework for analyzing and partitioning the sources of uncertainty that control predictability. The implications of this framework are assessed conceptually and linked to classic questions in ecology, such as the relative importance of endogenous (density‐dependent) vs. exogenous factors, stability vs. drift, and the spatial scaling of processes. The framework is used to make a number of novel predictions and reframe approaches to experimental design, model selection, and hypothesis testing. Next, the quantitative application of the framework to partitioning uncertainties is illustrated using a short‐term forecast of net ecosystem exchange. Finally, I advocate for a new comparative approach to studying predictability across different ecological systems and processes and lay out a number of hypotheses about what limits predictability and how these limits should scale in space and time.
Control of autoimmune inflammation using liposomes to deliver positive allosteric modulators of metabotropic glutamate receptors
Authors: Gammon Joshua M. , Adapa Arjun R. , Jewell Christopher M.
Published: June 2017

Multiple sclerosis (MS) is an autoimmune disease where myelin is incorrectly recognized as foreign and attacked by the adaptive immune system. Dendritic cells (DCs) direct adaptive immunity by presenting antigens to T cells, therefore serving as a target for autoimmune therapies. N‐Phenyl‐7‐(hydroxyimino) cyclopropa[b]chromen‐1a‐carboxamide (PHCCC), a positive allosteric modulator of metabotropic glutamate receptor 4 (mGluR4), can promote regulatory T cells by altering cytokine secretion to bias T cell differentiation. The therapeutic potential of PHCCC, however, is hindered by dose‐limiting toxicity, poor solubility, and the need for frequent dosing. We hypothesized liposomal delivery of PHCCC might enable safe, effective delivery of this hydrophobic drug to exploit metabolism as a means of controlling inflammation in self‐reactive immune cells. PHCCC was readily encapsulated in liposomes modified with polyethylene glycol. Under sink conditions, controlled release resulted in 58% of drug released into media over 18 hours. Culture of primary DCs with PHCCC liposomes reduced pro‐inflammatory cytokine secretion while reducing toxicity four‐fold compared with soluble PHCCC. During co‐culture of DCs with myelin‐reactive T cells from transgenic mice, PHCCC liposomes reduced T cell proliferation and interferon gamma secretion. These results support the potential of using liposomes to promote tolerance through biocompatible delivery of metabolic modulators. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 2977–2985, 2017.
Duration and cessation characteristics of heparinization after finger replantation: A retrospective analysis of outcomes
Authors: Efanov Johnny I. , Khriguian Julia , Cassier Sophie , Boghossian Elie , Harris Patrick G. , Bou‐Merhi Joseph , Danino M. A.
Published: June 2017

Background

To prevent postoperative thrombosis, indications for anticoagulation in finger replantation have been described, but no consensus has yet been found for cessation protocols. The aim of this study is to investigate cessation methods of intravenous anticoagulation after finger replantation.

Methods

A retrospective review of all patients treated for a finger replantation between December 2014 and July 2016 was performed. Only those who required postoperative treatment with intravenous heparin were extracted. Primary outcome was survival of finger at hospital discharge and data collection focused on postoperative anticoagulation regimens.

Results

108 patients with replantation were treated with intravenous heparin and included in the analysis. When anticoagulated, survival rate was 60% (n = 65) at hospital discharge, wherein arterial and venous thrombosis accounted for 60 and 40% respectively. Descriptive analysis failed to demonstrate an increase in failure rates when tested for duration of intravenous heparin, fixed or variable infusion rates of anticoagulation and need for vascular grafts. However, there was a 2.8‐fold (P = .009) increase in the survival rate with progressive weaning of anticoagulation rather than abrupt discontinuation. Subgroup analysis demonstrated similar findings when considering arterial thrombosis alone (OR 5.2, P = .012), but did not show any significant difference for venous thrombosis (OR 1.7, P = .344).

Conclusions

Progressive tapering of intravenous heparin is associated with an increased survival rate after finger replantation, particularly for arterial thrombosis. Further prospective and randomized trials are necessary to elucidate the optimal duration, method of infusion and indications for vascular grafts.
Error bounds of singular boundary method for potential problems
Authors: Li Junpu , Chen Wen , Gu Yan
Published: June 2017

The singular boundary method (SBM) is a recent strong‐form boundary collocation method free of integration, mesh, and fictitious boundary. Although an extensive study has been reported in the literature on improving its accuracy and stability as well as its applications to diverse problems, little, however, has been done to analyze its convergence mathematically. The main purpose of this paper is to derive the explicit error bounds of the SBM for potential problems as well as to explain the essential difference between the origin intensity factor (OIF) in the SBM and the singular integration in the boundary element method (BEM). In the process of derivation, we also illustrate the physical meaning of OIF and explain the reason why the OIF has the function to correct the discretization error on the boundary. Finally, several benchmark examples are given to verify the effectiveness of the conclusions obtained from this article, as well as to investigate the different convergence behaviors between the SBM and BEM. It can be found that the SBM has the explicit error bound and is mathematically a stable technique.© 2017 Wiley Periodicals, Inc. Numer Methods Partial Differential Eq 33: 1987–2004, 2017
A degradable atom transfer radical polymerization inimer: Synthesis, polymerization, and cleavage of the resulting polymer products
Authors: Elladiou Marios , Patrickios Costas S.
Published: June 2017

A novel degradable inimer for atom transfer radical polymerization (ATRP), 2‐(6‐(2‐((2‐bromo‐2‐methylpropanoyl)oxy)ethyl)pyridin‐2‐yl)ethyl methacrylate (PyDEBrMΑ), was synthesized by the two‐step esterification of 2,6‐pyridinediethanol, first with α‐bromoisobutyryl bromide in order to introduce the initiator moiety, and then with methacryloyl chloride in order to introduce the monomer moiety. PyDEBrMA was subsequently used to initiate the self‐condensing ATRP of methyl methacrylate (MMA) to obtain a hyperbranched MMA homopolymer which could be cleaved at the PyDEBrMA residue either by treatment under mildly alkaline hydrolysis conditions (sodium deuteroxide in d6‐DMSO at room temperature) or thermolysis at 150 °C. The lability of the PyDEBrMA residue arises from the presence in its structure of two 2‐(pyridin‐2‐yl)ethyl ester moieties. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017, 55, 2831–2839
The role of boundary‐layer friction on tropical cyclogenesis and subsequent intensification
Authors: Kilroy Gerard , Montgomery Michael T. , Smith Roger K.
Published: June 2017

A recent idealized, high‐resolution, numerical model simulation of tropical cyclogenesis is compared with a simulation in which the surface drag is set to zero. It is shown that, while spin‐up occurs in both simulations, the vortex in the one without surface drag takes over twice as long to reach its intensification begin time. When surface friction is not included, the inner core size of the simulated vortex is considerably larger and the subsequent vortex intensity is significantly weaker than in the case with friction. In the absence of surface drag, the convection eventually develops without any systematic organization and lies often outside the radius of azimuthally averaged maximum tangential winds. The results underscore the crucial role of friction in organizing deep convection in the inner core of the nascent vortex and raise the possibility that the timing of tropical cyclogenesis in numerical models may have an important dependence on the boundary‐layer parametrization scheme used in the model.
The relationship between emotion regulation strategies and job search behavior among fourth‐year university students☆
Authors: Wang Ling , Xu Huihui , Zhang Xue , Fang Ping
Published: June 2017

The job search process is a stressful experience. This study investigated the effect of emotion regulation strategies on job search behavior in combination with anxiety and job search self‐efficacy among Chinese university fourth‐year students (N = 816, mean age = 21.98, 31.5% male, 34.9% majored in science, 18.0% from “211 Project” universities). Results showed that cognitive reappraisal was positively related to job search behavior, while expressive suppression was negatively related to job search behavior. Additionally, anxiety was negatively related to job search behavior, while job search self‐efficacy was positively associated with job search behavior. Moreover, both anxiety and job search self‐efficacy mediated the relationship between emotion regulation strategies and job search behavior. In general, emotion regulation strategies played an important role in job search behavior. Implications include the notion that emotion regulation interventions may be helpful to increase job search behavior among university students.
Olympic class laser sailing dinghy uses world class composite materials
Authors: Stowell Jon
Published: June 2017

The International Laser Class sailboat, also referred to as the Laser Standard, but most commonly called a Laser®, is a popular one-design fiberglass dinghy that is sailed the world over, with sales in excess of 220,000 boats. Over the last 46 years, Laser has grown to become a globally recognized sailing class and brand. It received a massive popularity boost in 1996 when Laser Standard became a new single-handed men's Olympic sailing class, with Robert Scheidt of Brazil (Gold), Ben Ainsle of GB (Silver) and Peer Moberg of Norway (Bronze) winning the first Laser class Olympic games medals in Atlanta, USA. In 2008, the Laser Radial, with a smaller sail, was first sailed as a new women's single-handed Olympic-class boat in Beijing.
Timothy A. Cohn (1957–2017)
Authors: Hirsch Robert
Published: June 2017

Cohn emphasized the use of hydrologic science for the public good, to protect ordinary citizens from flood and pollution hazards and to reduce losses from natural disasters.