bluuebunny/crossref_metadata_2025 huggingface dataset:
Bone Morphogenetic Protein-9 Controls Pulmonary Vascular Growth and Remodeling
Authors: Berrebeh Nihel , Mbouamboua Yvon , Thuillet Raphaël , Ottaviani Mina , Chelgham Mustapha Kamel , Magnone Virginie , Desroches-Castan Agnès , Ricard Nicolas , Anegon Ignacio , Remy Séverine , Schermuly Ralph Theo , Lebrigand Kevin , Kojonazarov Baktybek , Savale Laurent , Humbert Marc , Bailly Sabine , Barbry Pascal , Tu Ly , Guignabert Christophe
Published: June 2023

Background

Pulmonary arterial hypertension (PAH), a life-limiting condition characterized by dysfunction of pulmonary microvascular endothelium, is predisposed by mutations in several genes that are critical for the proper activation of specific bone morphogenetic protein (BMP) receptor complexes that phosphorylate intracellular Smad1/5/8 in endothelial cells. However, the functional importance of BMP-9 (GDF2), one of the high affinity ligands for ALK1 (ACVRL1) and BMPR-II (BMPR2), for the pulmonary microvasculature remains imperfectly understood.

Objective

The aim of this study was first to determine thein vivoimpact of BMP-9 deficiency on pulmonary vascular growth and remodeling, then to assess whether ALK1 expression can alter BMP-9 transcriptional signatures in human pulmonary microvascular endothelial cells (PMECs).

Methods

CRISPR-Cas9gene editing was used to createGdf2knockout rats inSprague Dawleybackground. Computed micro-tomography (Micro-Ct) scan after Microfil perfusion was performed to generate high-resolution 3D-images of the pulmonary arterial tree. The influence of ALK1 abundance on the transcriptional signatures of BMP-9 responses in human PMECs was assessed by single cell (sc)-RNAseq. Functional studies were performed using human PMECs exposed to BMP-9, the ALK1/2 inhibitor ML347, and ALK1-Fc fusion protein that neutralizes BMP9/10 and two animal models of severe pulmonary hypertension (PH).

Results

Micro-Ct angiography revealed structural and functional remodeling along the pulmonary vascular tree in BMP-9 deficient rats, resulting in vasodilation and increase in vascular density. scRNA-seq experiments identified distinct transcriptional signatures in human PMECs in response to BMP-9 responses. ALK1 expression had a direct impact on both proangiogenic capacities and transcriptional responses of PMECs to BMP-9. Functional studies performed in human PMECs confirmed that abundance of BMP-9 and ALK1 acted as modulators of PMEC tube formation, migration and proliferation, and also of vascular endothelial growth factor (VEGF)/VEGFR activities. The structural and functional remodeling observed inGdf2knockout rats coincided with a lower susceptibility to develop severe PH induced by monocrotaline (MCT) and SU5416+hypoxia (SuHx).

Conclusion

BMP-9 and ALK1 are critical modulators of pulmonary vascular growth and remodeling. Our results provide potential mechanisms explaining why BMP-9 deficient animals are less susceptible to the rise in pulmonary vascular resistance in experimental models of PH.
dsRID: Editing-free in silico identification of dsRNA region using long-read RNA-seq data
Authors: Yamamoto Ryo , Liu Zhiheng , Choudhury Mudra , Xiao Xinshu
Published: June 2023

Double-stranded RNAs (dsRNAs) are potent triggers of innate immune responses upon recognition by cytosolic dsRNA sensor proteins. Identification of endogenous dsRNAs helps to better understand the dsRNAome and its relevance to innate immunity related to human diseases. Here, we report dsRID (double-stranded RNA identifier), a machine learning-based method to predict dsRNA regionsin silico, leveraging the power of long-read RNA-sequencing (RNA-seq) and molecular traits of dsRNAs. Using models trained with PacBio long-read RNA-seq data derived from Alzheimer’s disease (AD) brain, we show that our approach is highly accurate in predicting dsRNA regions in multiple datasets. Applied to an AD cohort sequenced by the ENCODE consortium, we characterize the global dsRNA profile with potentially distinct expression patterns between AD and controls. Together, we show that dsRID provides an effective approach to capture global dsRNA profiles using long-read RNA-seq data.
Age-dependent increase in tau phosphorylation at serine 396 in Huntington’s disease pre-frontal cortex
Authors: Petrozziello Tiziana , Huntress Sommer S. , Castillo-Torres Ayleen L. , Quinn James P. , Connors Theresa R. , Auger Corinne A. , Mills Alexandra N. , Kim Spencer E. , Liu Sophia , Mahmood Farah , Boudi Adel , Wu Muzhou , Sapp Ellen , Kivisäkk Pia , Sunderesh Shekar R. , Pouladi Mahmoud A. , Arnold Steven E. , Hyman Bradley T. , Rosas H. Diana , DiFiglia Marian , Pinto Ricardo Mouro , Kegel-Gleason Kimberly , Sadri-Vakili Ghazaleh
Published: June 2023

Background

To date, it is still controversial whether tau phosphorylation plays a role in Huntington’s disease (HD), as previous studies demonstrated either no alterations or increases in phosphorylated tau (pTau) in HD post-mortem brain and mouse models.

Objectives

The goal of this study was to determine whether total tau and pTau levels are altered in HD.

Methods

Immunohistochemistry, cellular fractionations, and western blots were used to measure tau and pTau levels in a large cohort of HD and control post-mortem prefrontal cortex (PFC). Furthermore, western blots were performed to assess tau, and pTau levels in HD and control isogenic embryonic stem cell (ESC)-derived cortical neurons and neuronal stem cells (NSCs). Similarly, western blots were used to assess tau and pTau inHttQ111and transgenic R6/2 mice. Lastly, total tau levels were assessed in HD and healthy control plasma using Quanterix Simoa assay.

Results

Our results revealed that, while there was no difference in tau or pTau levels in HD PFC compared to controls, tau phosphorylated at S396 levels were increased in PFC samples from HD patients 60 years or older at time of death. Additionally, tau and pTau levels were not changed in HD ESC-derived cortical neurons and NSCs. Similarly, tau or pTau levels were not altered inHttQ111and transgenic R6/2 mice compared to wild-type littermates. Lastly, tau levels were not changed in plasma from a small cohort of HD patients compared to controls.

Conclusion

Together these findings demonstrate that pTau-S396 levels increase significantly with age in HD PFC.
Complexity of baseline cognitive and psychological status in haematology patients planned for chimeric antigen receptor T-cell therapy
Authors: Kuznetsova Valeriya , Rosenfeld Hannah , Sales Carmela , van der Linde Samantha , Roos Izanne , Roberts Stefanie , D’Aprano Fiore , Loi Samantha M , Dowling Mark , Dickinson Michael , Kalincik Tomas , Harrison Simon J , Anderson Mary Ann , Malpas Charles B
Published: June 2023

Background

Immune effector cell-associated neurotoxicity syndrome (ICANS) is a relatively common consequence of chimeric antigen receptor T-cell (CAR-T) therapy, with a wide range of possible cognitive presentations. The aim of this study was to characterise a real-word cognitive and psychological status of patients with advanced haematologic and solid organ malignancies planned for CAR-T. We also aimed to examine utility of two cognitive screening approaches.

Methods

Patients underwent specialist cognitive assessment, including a self-report questionnaire of psychopathology and subjective cognitive function. A subset of individuals also completed the Montreal Cognitive Assessment (MoCA).

Results

Of 60 patients included, 15-16 (25%-27%) presented with evidence of cognitive impairment, with six unique patterns of dysfunction. Impaired patients were more likely to have B-cell acute lymphoblastic leukaemia (BF10=9.30), be younger (BF10=7.76), have bone marrow involvement (BF10=5.18), report history of anxiety (BF10=4.85), or have evidence of psychopathology (BF10=31.30). Analyses did not support the utility of cognitive screening. Of those patients who completed a self-report measure of psychopathology, nine (15.8%) were elevated on at least one symptom domain.

Conclusions

The findings demonstrate a broad spectrum of dysfunction and psychopathology in this cohort, emphasising the importance of baseline evaluation for detecting cognitive neurotoxicity symptoms that might arise after CAR-T infusion.
Associations of social media use with tobacco smoking and e-cigarettes: a national longitudinal study
Authors: Hopkinson Nicholas S. , Vrinten Charlotte , Parnham Jennie C. , Radó Márta K. , Filippidis Filippos T. , Vamos Eszter , Laverty Anthony A.
Published: June 2023

Background

Social media may influence children and young people’s health behaviour, including smoking and e-cigarette use.

Methods

We analysed data from participants aged 10-25 in the UK Household Longitudinal Study 2015-2022. The amount of social media use reported on a normal weekday, was related to current tobacco smoking and e-cigarette use. Generalised Estimating Equation (GEE) logistic regression models investigated associations of social media use with tobacco and e-cigarette use. Models controlled for possible confounders including age, sex, country of UK, ethnicity, household income and use of tobacco/e-cigarettes by others within the home.

Results

Among 10,808 participants with 27,962 observations, current tobacco smoking was reported by 2,237(20.7%) at least one time point, and current e-cigarette use by 1,013 participants (9.4%). In adjusted GEE models, increasing use of social media was associated with greater odds of current smoking and this was particularly apparent at higher levels of use (AOR 3.11, CI 2.41-4.03 for ≥7hours/day vs no use). Associations were similar for e-cigarettes, e.g. OR=3.04, CI 2.11-4.40 for ≥7hours social media use versus none).

Conclusions

Social media use is associated with an increased risk of e-cigarette and tobacco use, reinforcing the need for policies to address this as an avenue for marketing to children and young people.
Numerical and experimental studies of thermal performance enhancement for parabolic trough solar collector using none-circulated CuO/synthetic oil nanofluid
Authors: Elmnefi Mohamed , Al-Khazraji Waqas
Published: June 2023

Purpose

One of the existing and commonly used solar energy harvesting devices is the parabolic trough solar collector (PTSC). Because of their ability to operate in low and medium temperatures, parabolic trough concentrators are widely used in power generation plants and industrial process heating applications. Therefore, the investigation of how different operating conditions affect these devices’ overall efficiency has received a great deal of attention in the recent decade. This study aims to enhance the thermal performance of the PTSC and reduce the system cost.

Design/methodology/approach

In the novel configuration, a noncirculated nanofluid absorbs solar radiation through a glass wall. The base fluid was synthetic oil (5W30), and the nanoparticles used were copper oxide. The heat captured is immediately absorbed by the water circulating inside the copper tube immersed in the nanofluid. ANSYS FLUENT 15.0 was used for carrying out computational fluid dynamics simulations for two models of single and triple copper tubes. The experimental results obtained from a test rig constructed for this purpose were compared with the numerical outcomes of the single copper tube model.

Findings

The findings of the simulation demonstrated that performance was superior for the single copper tube model over the triple copper tube model. The numerical findings of the single copper tube model were compared with the experimental results. The numerical and experimental results differed from 3.17% to 5.6%. Investigations were carried out to study the effects of varying the volumetric flow rate of (20, 40, 60 and 80 L/h) and water inlet temperatures of (300, 315 and 330 K) on the effectiveness and performance of the newly developed model. Additionally, two nanofluid volume fractions of 0.05% and 0.075% were used for investigating their effect on the performance of the novel configuration. According to the findings, the highest thermal efficiency of 55.31% was recorded at 0.075% concentration and 80 L/h volume flow rate.

Originality/value

In this study, a novel direct absorption solar collector configuration using a noncirculated nanofluid was designed to enhance the thermal efficiency of PTSC. This new approach makes it possible to boost the thermal performance of the PTSC and lower the system’s cost.
Analysis of training effectiveness from the perspective of managers and employees in the Colombian hospitality industry
Authors: Gil Alfonso J. , Rodriguez-Cavides Linzay , Romero-Daza Deyanith
Published: June 2023

Purpose

The literature has defined different indicators of training effectiveness. At the performance indicator level of analysis, training effectiveness measures the impact of training on knowledge, skills and job performance. This paper aims to analyse, from the perspective of managers and employees from the hotel sector in Colombia, the relationships between the improvement of knowledge and skills and the improvement of job performance.

Design/methodology/approach

The research technique used is a survey. Data are collected from a sample of managers and a sample of employees from the Colombian hospitality industry. The hypotheses are contrasted through regression analysis.

Findings

From the managers’ perspective, the data indicate a significant relationship between the improvement of knowledge and work performance. In contrast, there is no significant relationship between improving skills and improving job performance. From the employees’ perspective, significant relationships between the improvement of knowledge and the improvement of skills in job performance are revealed.

Originality/value

This work makes significant contributions to the training literature. It analyses the relationships among indicators of training effectiveness from the point of view of managers and employees from the Colombian hotel sector. It reveals differences between the perspectives of managers and employees.
Examining the effects of CSR on organizational attractiveness: perception study of job seekers in India
Authors: Ali Esrafil , Satpathy Biswajit , Gupta Deepika R.
Published: June 2023

Purpose

The purpose of this paper is to study the effect of corporate social responsibility (CSR) effectiveness on job seekers’ organizational attractiveness (JSA). Deriving inspiration from Carroll’s theory, the study specifically tries to measure the impact of CSR on JSA with the four dimensions pertaining to economics (PECO), pertaining to legal compliance (PLCO), pertaining to ethics (PETH) and pertaining to philanthropic (PPH). Furthermore, the paper also tries to examine the moderating role of company selection (COM SEL) done based on high or low CSR reputation and JSA.

Design/methodology/approach

Management and engineering students enrolled in premier institutions and universities of Western Odisha in India are surveyed for their perceptions of CSR and JSA. Purposive and convenience sampling are applied to collect data from 456 job seekers. Based on the analysis, the study proposes two main models (Models 1 and 2) wherein Model 1 tries to measure the effect of CSR on JSA and Model 2 checks the moderating effect of COM SEL on CSR and JSA. In addition, robustness of the study is tested using control variables (Models 3 and 4). Data is treated through SmartPLS 3.3 software. The structural equation modelling (partial least squares-SEM) method is applied to test the hypotheses and for further analysis.

Findings

The result reveals an interesting insight. There is a positive and significant effect of PECO, PLCO and PPH on JSA. Moreover, no such significant effect is observed between PETH and JSA. Further, the findings are contrary with respect to COM SEL, that partially moderates the effect of CSR on JSA. However, the results reveal that COM SEL has a substantial moderating effect on the PPH dimension of CSR and JSA.

Practical implications

The results highlight that CSR positively and significantly affects JSA in terms of PECO, PLCO and PPH, thereby emphasizing that organizations must be more focused on these perspectives of CSR. Further, though the results did not exhibit any significance with PETH, it is essential that organizations should strengthen the ethical aspects of CSR as well and align them with the CSR strategic actions. The study also confirms the moderating effect of COM SEL on PPH dimension of CSR and JSA, thereby supporting the philanthropic approach in this domain. Further, the organizations should foresee the philanthropic factor of CSR as a competitive advantage to attract potential job seekers.

Originality/value

This research attempts to contribute to CSR and HR literature in two ways. First, it is the first attempt to use PLS-SEM with an attempt to understand job seekers’ perception of CSR and JSA with Indian data consisting of students belonging to premier business management and engineering institutes. Second, the study is an attempt to empirically measure the moderating effect of COM SEL on JSA. To sum up, the study will provide insights to organizations to help craft CSR strategies for attracting more job seekers.
Investigating consumer purchase decision based on switching barriers and decision postponement: moderating role of time pressure
Authors: Xue Pengsongze , Jo WooMi
Published: June 2023

Purpose

Although various booking platforms have been contributing to the dramatic growth of hotel industry, little research has been conducted to understand consumer psychological processes and behaviors in online hotel booking. To fill this gap, the current study examines the effect of switching barriers (switching cost and alternative attractiveness) on consumers' decision postponement and repurchase intention. Additionally, the moderating effect of time pressure in different phases of booking decision is investigated.

Design/methodology/approach

A total of 352 samples was collected through an online platform. Data analysis was conducted via Amos 23 (structural equation modeling) and SPSS 24 (descriptive analysis and PROCESS macro).

Findings

Results show that switching cost and alternative attractiveness are two significant drivers of decision postponement and repurchase intention. Meanwhile, time pressure only has a significant moderating effect on the relationship between switching cost and decision postponement.

Practical implications

The findings of this research reveal that hotel operations need to implement strategies to prevent customers' delayed booking decisions and overcome the influence of time pressure on customer decision-making.

Originality/value

These findings stress the importance of consumer perceptions of switching barriers and time span when making hotel reservations online. Hotel practitioners are encouraged to provide multiple human–computer interaction applications to attract novice consumers and increase their familiarity with booking process.
A feasibility study to identify the presence of autism specific risk factors in secure services using an autism specific framework
Authors: Skelhorn Esther , Girardi Alessandra , Cooper-Evans Sam
Published: June 2023

Purpose

Some individuals with autism may engage in violent behaviour. Research into autism specific factors (ASFs) that may contribute to violence is limited. The purpose of this paper is to explore the feasibility of use of an ASF framework which was developed to inform risk formulation and treatment needs.

Design/methodology/approach

Retrospective identification and evaluation of ASFs in offenders with autism (N = 13) at childhood, time of index offence and in current risk behaviours. The ASFs described in the framework were repetitive behaviours and circumscribed interests; poor social understanding and empathy; sensitivity to sensory stimulation; and disruption to rigid behavioural routines or difficulties coping with change.

Findings

There was evidence for all four ASFs being consistently present in childhood, contributing to violent behaviour at the index offence and current risk behaviours in at least one case. Poor social understanding and empathy was often present at both childhood and index offence in all cases. Of the seven cases with offence paralleling behaviour, five had at least one ASF present at each timepoint.

Practical implications

This proof-of-concept study provides initial support that ASFs play a role in offending behaviour of individuals with autism. Clinicians working in specialist and generic forensic services, with an in-depth knowledge of autism, could use the ASF framework to enhance risk assessments and facilitate more targeted treatment planning for offenders with autism in specialist and general forensic services.

Originality/value

To the best of the authors’ knowledge, this study is the first to test the application of the ASF framework in an autistic offending population.
Learning and programming challenges of React.js open-source framework
Authors: Hasnain Muhammad , Ullah Sami
Published: June 2023

Purpose

This paper aims to examine the role of Open Artificial Intelligence application (ChatGPT) to identify challenges faced by developers working on React.js libraries.

Design/methodology/approach

Scopus and Google Scholar databases were searched for the literature. In addition, ChatGPT application was accessed to extract contents regarding its potential role in identifying challenges and their solutions for developers.

Findings

This paper found that ChatGPT has potential in identifying challenges, faced by learners and developers. ChatGPT enables developers to navigate the projects’ libraries and overcome steep learning curve issue. ChatGPT excels in helping the developers by presenting a range of valuable strengths. These include offering tutorials and document support, providing comprehensive programming challenges solutions, assisting with the configuration and adding in debugging process of React.js application.

Originality/value

To the best of the authors’ knowledge, this is one of the first articles presenting the potential role of ChatGPT in identifying and offering solutions to the challenges of learners and programmers about React.js.
Use of geographical information system (GIS) application in public libraries
Authors: Hussain Abid
Published: June 2023

Purpose

The purpose of this study is to describe the role of geographical information system (GIS) in public libraries. The study shed light on various functions of GIS in the public library scenario. It further elaborates on the scope of GIS, its functions and the multiple challenges faced by library staff in implementation in public library.

Design/methodology/approach

A qualitative study was conducted by exploring articles published in top databases like Elsevier, Taylor and Francis, SpringerLink, Google Scholar, etc. The study reveals that GIS has been part of multiple businesses for the past few years, and its role is expanding at an alarming rate in public libraries for the past 10 years.

Findings

The study reveals that GIS deals with the geospatial characteristics of the data set, and the public library’s prime role is to visualize large quantities of disparate data in one data set.

Originality/value

The study will further wider the scope of the GIS in public library scenario. Experts in GIS and library field will get an extensive information and optimum benefits by reading this paper.
The production and pricing strategy of the two-echelon remanufacturing supply chain with government subsidy under patent protection
Authors: Cao Xiaogang , Wen Hui , Cao Bowei
Published: June 2023

Purpose

In this paper, the authors study the production and pricing decisions of a remanufacturing supply chain composed of a supplier, an assembler and a remanufacturer, in which the remanufacturing of components requires patent licensing from the supplier.

Design/methodology/approach

The authors consider three different models with government subsidy for remanufacturing: (1) no government subsidies; (2) the government subsidizes the remanufacturing behavior of the supplier and (3) the government subsidizes the remanufacturing behavior of the remanufacturer and use the Stackelberg game model to solve and analyze the equilibrium wholesale prices of components and the equilibrium outputs of new and remanufactured products under three subsidy modes.

Findings

The results show that the equilibrium wholesale prices of two kinds of components decrease with the unit patent licensing fee and the unit government subsidy, and the equilibrium quantity of the remanufactured products under the three modes is obviously higher than that of the new products.

Originality/value

Finally through numerical simulation, it is found that the equilibrium profits of the supplier, the manufacturer and the supply chain increase monotonously in relation to the unit government subsidy, while the optimal profit of the assembler in relation to the unit government subsidy tends to decrease first and then increase.
Does technology make start-ups resilient amidst COVID-19? A qualitative enquiry
Authors: Tiwari Anubhav , Das Payel , Dubey Ritesh Kumar , Kaur Tavleen , Dixit Saurabh Kumar , Mandal Santanu
Published: June 2023

Purpose

This paper aims to explore the challenges faced by start-ups during COVID-19 and highlight solutions for catering to the new-normal consumer behaviour. The study accounts for 15 deep-tech start-ups sailing through the pandemic and their responsiveness. This study brings forth insights and experiences from the Indian start-up founders and CEOs during COVID-19.

Design/methodology/approach

This study uses a qualitative approach and is exploratory and phenomenological. A purposive sample of 15 young start-ups founded between the years 2013–2020 by founders aged between 24 and 41 was selected for the study. The recorded telephonic interview was collected from the founders from April 2021 to September 2021. The thematic analysis of the study evolves from Braun and Clarke (2006) using the MAXQDA 2020.

Findings

The study emphasizes upon challenges faced by start-ups, crisis management of start-ups and the relevance of technology-based start-ups during challenging times. This research provides a qualitative framework to establish the role of the technology acceptance model (TAM) towards the adaptability, responsiveness and resilience demonstrated by the start-ups. The findings also highlight the solutions to address challenges faced by start-ups and road to recovery.

Practical implications

The study has great relevance and lessons for budding entrepreneurs during crisis management. The study has implications for corporations and governments in terms of setting up incubators and accelerators to support budding entrepreneurs.

Originality/value

The study is unique in highlighting the relevance and importance of TAM for start-ups during crisis management like COVID-19. The study thrusts upon the need of technology acceptance for better crisis management.
“I would want to see young people working in here, that’s what I want to see…” how peer support opportunities in youth offending services can support a Child First, trauma-informed, and reparative model of practice for youth justice
Authors: Thompson Naomi , Spacey Meghan
Published: June 2023

Purpose

This paper aims to explore how peer support can support a combined Child First, trauma-informed and restorative approach for youth justice. While other scholars have identified clashes between these approaches, particularly between Child First and restorative approaches, a focus on reparative practice with peers has been under-explored as a more child-centred model for reparation-focused work.

Design/methodology/approach

We draw on qualitative data from interviews and surveys undertaken with young people and parents/caregivers in a London youth offending service (YOS). The data was part of a broader mixed-methods study in the YOS that used observational methods alongside surveys and interviews to evaluate the effectiveness of its model of practice. Peer support emerged as a theme.

Findings

Participants expressed the desire to see young people working and volunteering in the YOS and felt this would help make it a safe and non-threatening space. Young people who had completed their time with the YOS saw themselves as role models with the insight and skills to support others. These young people expressed a strong desire to work in the YOS and, in some cases, to develop long-term careers supporting young people.

Originality/value

Our research challenges the notion that young people who have been involved in crime struggle to empathise, providing rich examples of their empathic understanding for peers. Peer support opportunities could offer a reconceptualisation of restorative practice that is Child First and trauma-informed. Such opportunities would benefit both the young people being supported and those offering support, building a co-produced approach that is directly informed by the expressed needs and desires of the young people.
A call for critical PDS: infusing DisCrit into the nine essentials
Authors: Damiani Michelle L. , Elder Brent C.
Published: June 2023

Purpose

The field of Professional Development Schools (PDS) continues to evolve with promising implications. As part of advancing practice, the National Association for Professional Development Schools has updated its nine essential guiding principles, which now includes an explicit expectation for all PDS partners to advance equity, anti-racism and social justice. This article is a call for critical professional development work which infuses Disability Critical Race Theory (DisCrit) practices into achieving the Nine Essentials.

Design/methodology/approach

In this call-to-action article, the authors argue that it is imperative for the whole of PDS work to establish a priority for inclusive practice that recognizes and responds to all aspects of diversity in education from the outset, including disability. The authors suggest that PDS work must be guided by an intersectional approach that is operationalized to achieve equity in education by dismantling both racism and ableism in education. The authors use an action-based example from our PDS work to exemplify these elements in practice.

Findings

In this article, the authors put forth two arguments that they urge their PDS colleagues to consider. First, the authors call for practices within PDS to give attention to improving student learning in ways that specifically address disability and intersectional considerations related to disability. Second, the authors urge that PDS work must be conceptually and practically inclusive in order to achieve the social justice impact put forth in the comprehensive mission of the Nine Essentials.

Originality/value

There is a growing body of literature around PDS that addresses theory to practice research and best practices in PDS settings. While some recent publications address inclusive PDS practices, the authors were not able to identify any works related to DisCrit in the PDS literature to date.
Investigation on pore properties, thermal conductivity, and compressive behavior of fly ash/slag‐based geopolymer foam
Authors: Zhou Huafei , Xu Zhechen , Xie Ziling , Hong Hengda
Published: June 2023

Geopolymer foam has emerged as a promising inorganic porous material in the last decade. Despite of the numerous advantages, there are some pending issues to be addressed, on top of that is the low compressive strength. To overcome this, this study synthesizes a high‐strength geopolymer foam by the partial substitution of fly ash (FA) with ground granulated blast furnace slag and carries out an intensive investigation into its microstructure, pore properties, thermal conductivity as well as compressive behavior. The microstructure is firstly analyzed by X‐ray diffraction and Fourier transform infrared spectroscopy techniques. The pore characteristics are also scrutinized, including pore size distribution, total porosity and water absorption. Then, the thermal conductivity is investigated and the applicability of basic effective thermal conductivity models to characterize the relationship with total porosity is evaluated. Afterward, the compressive strength together with the softening coefficient is examined, and the relationship with total porosity is also studied. Finally, comparisons between the proposed geopolymer foam and other FA‐based geopolymer foams in the literature are performed. The results show that the proposed geopolymer foam possesses not only a comparable thermal conductivity but also a far superior compressive strength, which sheds light on the widespread applications in thermal insulation.
Comparison of the Hysteresis Response of Super-Coiled Polymer Actuators
Authors: Henry Josh H. P. , Bridge Jacqueline
Published: June 2023

In recent years, super-coiled polymer (SCP) actuators have been investigated as a higher yield, low-cost alternative to conventional actuators. A major challenge has been finding appropriate general and industry uses for these actuators due to their hysteretic response. This paper seeks to compare the response for SCP actuators based on different thread weights and sizes and thus suggest possible directions for their use. The actuators were produced through coiling and heat training controlled via Arduino. The responses were obtained by supplying a controlled voltage to the system. The response was filmed and processed using matlab; the resulting displacement and strain were used to observe the hysteretic characteristics. Based on the characteristics noted, different applications were recommended for these SCP actuators. It is recommended that this research into SCP actuators be furthered by developing hysteresis models for compensation, control, and exploring their use in robotic systems and tactile mechanisms.
Statistical Distribution Model of Charpy Absorbed Energy in Transition Temperature Range for Reactor Pressure Vessel Steel
Authors: Miura Naoki , Shinko Tomoki
Published: June 2023

A statistical model to estimate the distribution characteristics of Charpy absorbed energy in the transition temperature range was proposed based on the variation in fracture toughness addressed by the Master Curve and the relationship between fracture toughness and Charpy absorbed energy associated with the Charpy Master Curve. Charpy absorbed energy in the transition temperature range can be well approximated by both the Weibull and normal distributions, and the parameters to determine the shape of the distributions (scale and shape parameters of the Weibull distribution, mean and standard deviation of the normal distribution) can be deductively defined as the functions of two independent variables, median of the fracture toughness and the difference between reference temperature and Charpy reference temperature. A series of Charpy impact tests were conducted under the same conditions to obtain the characteristics of the variation in Charpy absorbed energy for a reactor pressure vessel steel SQV2A base metal, and the experimental variation was reasonably predicted by the proposed model.
Antibody-mediated immunity against lung cancer goes retro
Authors: Langel Stephanie N. , Martinez David R.
Published: June 2023

Endogenous retrovirus antibody responses contribute to survival after immune checkpoint blockade therapy against lung adenocarcinoma.
Phosphorylation of E2 Serine Residue 402 Is Required for the Transcription and Replication of the HPV5 Genome
Authors: Lototskaja Elina , Liblekas Lisett , Piirsoo Marko , Laaneväli Airiin , Ibragimov Ruslan , Piirsoo Alla
Published: June 2023

Human papillomavirus type 5 (HPV5) may play a role in the development of specific types of cutaneous and head and neck cancers. The persistence of the HPV genome in host cells depends on the activity of its proteins, namely, a helicase E1 and transcription/replication factor E2.
Biapenem, a Carbapenem Antibiotic, Elicits Mycobacteria Specific Immune Responses and Reduces the Recurrence of Tuberculosis
Authors: Pahuja Isha , Verma Akanksha , Ghoshal Antara , Mukhopadhyay Suparba , Kumari Anjna , Shaji Aishwarya , Chaturvedi Shivam , Dwivedi Ved Prakash , Bhaskar Ashima
Published: June 2023

Tuberculosis (TB) caused by
Mycobacterium tuberculosis
(
M.tb
) tops the list of infectious killers around the globe. The emergence of drug-resistant variants of
M.tb
has been a major hindrance toward realizing the “END TB” goal.
A Customized Novel Blocking ELISA for Detection of Bat-Origin Swine Acute Diarrhea Syndrome Coronavirus Infection
Authors: Cao Liyan , Kong Xiangyu , Li Xiangtong , Suo Xuepeng , Duan Yueyue , Yuan Cong , Zhang Yu , Zheng Haixue , Wang Qi
Published: June 2023

SADS-CoV was reported to be of high potential for dissemination among various of host species. Accurate serological diagnosis of SADS-CoV infection is key in managing the emerging SADS-CoV.
Anti-synthetase syndrome masquerading as recurrent pneumonia
Authors: Lio Ka U , Li Si
Published: June 2023

Anti-synthetase syndrome (ASS) is a rare inflammatory myopathy with a wide variety of clinical presentations. ASS-related interstitial lung disease (ASS-ILD) presents with rapid onset and progression, which could often be confused with other more common acute processes such as pneumonia, especially when ILD can be the sole manifestation. A woman in her 50s presented with recurrent dyspnoea for 2 months requiring multiple hospital admissions, and each time, she was diagnosed with multifocal pneumonia and treated with antibiotics. On admission, the evaluation revealed a markedly elevated creatine kinase level at 3258 U/L and a CT scan of the chest revealed worsening scattered ground-glass opacities. Given the concern for ILD as the cause of antibiotic failure, she underwent bronchoscopy with bronchoalveolar lavage which revealed non-specific interstitial pneumonia. A subsequent myositis panel revealed a positive anti-Jo-1 antibody, and she was diagnosed with ASS-ILD. She completed a course of intravenous immunoglobulin and methylprednisolone and experienced significant clinical improvement with the resolution of hypoxaemia and improved polyarthralgia.

ASS could often be misdiagnosed as other more common acute lung processes, as a clinically subtle course can escape detection given its rarity, as well as its non-specific and highly variable presentations. This case highlights the importance of early suspicion and consideration of performing specific autoantibody testing when evaluating patients with a suspicion of undifferentiated autoimmune condition.
BASE—high-precision comparisons of the fundamental properties of protons and antiprotons
Authors: Latacz B. M. , Arndt B. P. , Bauer B. B. , Devlin J. A. , Erlewein S. R. , Fleck M. , Jäger J. I. , Schiffelholz M. , Umbrazunas G. , Wursten E. J. , Abbass F. , Micke P. , Popper D. , Wiesinger M. , Will C. , Yildiz H. , Blaum K. , Matsuda Y. , Mooser A. , Ospelkaus C. , Quint W. , Soter A. , Walz J. , Yamazaki Y. , Smorra C. , Ulmer S.
Published: June 2023

The BASE collaboration at the antiproton decelerator/ELENA facility of CERN compares the fundamental properties of protons and antiprotons with ultra-high precision. Using advanced Penning trap systems, we have measured the proton and antiproton magnetic moments with fractional uncertainties of 300 parts in a trillion (p.p.t.) and 1.5 parts in a billion (p.p.b.), respectively. The combined measurements improve the resolution of the previous best test in that sector by more than a factor of 3000. Very recently, we have compared the antiproton/proton charge-to-mass ratios with a fractional precision of 16 p.p.t., which improved the previous best measurement by a factor of 4.3. These results allowed us also to perform a differential matter/antimatter clock comparison test to limits better than $$3\,$$

3

%. Our measurements enable us to set limits on 22 coefficients of CPT- and Lorentz-violating standard model extensions (SME) and to search for potentially asymmetric interactions between antimatter and dark matter. In this article, we review some of the recent achievements and outline recent progress towards a planned improved measurement of the antiproton magnetic moment with an at least tenfold improved fractional accuracy.

Graphic Abstract
On quarkonium masses in 3D non-commutative space
Authors: Bukor Benedek , Tekel Juraj
Published: June 2023

We modify the calculation of quarkonium masses using the radial WKB and Pekeris-type approximations for the case of three-dimensional, rotationally invariant non-commutative space. We obtain corrections to the charmonium ($${\text {c}}\bar{{\text {c}}}$$cc¯), bottomonium ($${\text {b}}\bar{{\text {b}}}$$bb¯) and bottom-charmed meson ($${\text {c}}\bar{{\text {b}}}$$cb¯) masses due to the discrete short distance structure of the space introduced by the space non-commutativity. For the fundamental length at the Planck scale we obtain relative correction at the order of$$10^{-39}$$10-39, and taking into account the current experimental data, we obtain the upper bound at the order of$${10^{-18}\,{{\text {m}}}}$$10-18mfor the fundamental length scale of space.
Off-shell chromomagnetic dipole moments of light quarks in the SM at and beyond the Z gauge boson mass scale
Authors: Montaño-Domínguez J. , Quezadas-Vivian B. , Ramírez-Zavaleta F. , Tututi E. S.
Published: June 2023

The anomalous chromomagnetic dipole moment, with the gluon off-shell, of the Standard Model (SM) light quarks ([Formula: see text], [Formula: see text], [Formula: see text], [Formula: see text] and [Formula: see text]), at the [Formula: see text] gauge boson mass scale, is computed by using the [Formula: see text] scheme. The numerical results disagree with all the previous predictions reported in the literature and show a discrepancy of up to two orders of magnitude in certain situations.
EXPERIMENTAL STUDIES ON THE SURFACE CHARACTERISTICS OF BIMETALLIC JOINTS INTERFACE FABRICATED THROUGH MICROWAVE IRRADIATION
Authors: KAUSHAL SARBJEET , KUMARI SAPNA , MUDGAL DEEPA , GUPTA DHEERAJ , VASUDEV HITESH
Published: June 2023

Surface characteristics of dissimilar metal joints interface play a crucial role on its functional performance. In this study, the microstructural, metallurgical and corrosion behavior of the microwave processed and TIG welded bimetallic joints interface surfaces were investigated. Metallurgical and mechanical properties of the joints interface surfaces were studied using SEM/EDS, XRD and microhardness techniques. The hot corrosion behavior study of both joints was carried out at elevated temperature in actual environment of biomass fuel-fired boiler as well as in simulated boiler environment. The after-corrosion behavior of both joints was analyzed using SEM and XRD methods. TIG-welded samples exhibited more loss in weight during both actual and simulated corrosion environments. The depletion of chromium from substrates in the actual corrosion environment proved that chromium is involved in controlling corrosion rates by forming the protective oxides during corrosion cycles.
The modulation of photonic band structures of silicon carbide polytype multilayers applicable in optical wave-guiding devices
Authors: Alsheikh M. , Alsalamah R. , Alshehri H. , Laref A.
Published: June 2023

In this study, we report photonic band structures and optical transmissions of some SiC polytypes, such as 3C, 2H, 4H, and 6H, and their multilayers, which have the form of a hexagonal photonic crystal at two-dimensional (2D) scale. Through the finite-difference time-domain computational simulations, we found that spatial electric-field variations of electromagnetic waves depend on the radius of dielectric rods of the multilayer crystal structure, and the central structural geometry of 4H- and 6H-SiC hexagonal polytypes was found to cause a remarkable increase of the wave vector [Formula: see text] in [Formula: see text] and [Formula: see text] directions. We also found a correlation between the local central structures of the optical modes in the 2D hexagonal crystal of 4H- and 6H-SiC polytypes. The wave-guiding in 4H- and 6H-SiC polytypes in the central core of the model geometry enabled the integration of defects to achieve a wide spectrum of technological functionalities, such as devices with striking features for miniaturized sensors and quantum information processing.
MINIMALLY INVASIVE SPINE SURGERY FOR POST-TRAUMATIC KYPHOSIS: A SYSTEMIC LITERATURE REVIEW AND RETROSPECTIVE CASE ANALYSIS
Authors: Yeh Chun , Lin Chia-Yu , Chen Hsien-Te
Published: June 2023

Study Design: Retrospective case analysis and systematic literature review.

Objective: To comprehensively review minimally invasive surgery (MIS) for post-traumatic kyphosis.

Methods: A systematic PubMed search was conducted for MIS and kyphotic deformities were published between 2012 and 2022. Sixteen patients between 2017 and 2021 met the criteria. Demographic data, surgical characteristics, and full-length radiographic parameters were collected pre- and post-operatively, and at final follow-up.

Results: Twenty-three articles were included. The mean age was 67 years, and the mean follow-up was 17 months. The mean operative time was 331 min and blood loss was 252 ml. Pre-operative radiographic outcomes were as follows: Lumbar lordosis (LL), [Formula: see text]; pelvic incidence (PI), [Formula: see text]; PI-LL mismatch, [Formula: see text]; pelvic tilt (PT), [Formula: see text]; and sagittal vertical axis (SVA), [Formula: see text] mm. At the final follow-up, LL was [Formula: see text] ([Formula: see text] = 0.51229), PI was [Formula: see text] ([Formula: see text] = 0.61438), PI-LL mismatch was [Formula: see text] ([Formula: see text] = 0.74696), PT was [Formula: see text] ([Formula: see text] = 0.00386), and SVA was [Formula: see text] mm ([Formula: see text] = 0.00465). The mean ODI and VAS scores for back pain at baseline and at 96 months follow-up were 33.2–19.7 and 8.4–2.5, respectively.

Conclusion: Age-adjusted MIS provides correction of sagittal alignment for posttraumatic kyphosis that satisfies patient demand.
MECHANICAL PLATFORM FOR THREE-DIMENSIONAL MODEL GENERATION OF FOOT POSTURE INDEX: A PRELIMINARY STUDY
Authors: CAHYADI WILLY ANUGRAH , MUKHTAR HUSNENI , SETIYADI SUTO , ANANTA FAHMI IHZA SULISTYA
Published: June 2023

A foot posture index (FPI-6) measurement is well presented as a straightforward clinical tool for diagnosing foot posture in patients. However, the FPI-6 diagnosis is mostly performed by a medical practitioner manually utilizing both palpation and rulers. Digital photos of the feet had been considered to digitize the FPI-6 assessment, unfortunately, the two-dimensional image is inadequate to identify two-palpation based on six criteria of FPI-6. This paper proposes a mechanical platform design for generating a three-dimensional (3D) model of the patient’s foot. The design is aimed to ease the test process of a large number of samples or participants as statistical data to estimate the foot posture based on the FPI-6 method. The 3D-generated models of the foot belonging to 37 children aged below 12 years old show that the FPI-6 Criteria 1 and 4 can be evaluated more clearly in the 3D models compared with flat 2D photos.