bluuebunny/crossref_metadata_2025 huggingface dataset:
A Review on Design of Coumarin Hybrids in the Treatment of Breast Cancer
Authors: Astha Astha , Rao U.S. Mahadeva , Ashawat M.S , Arora Rashmi , Zhen Lee Wan
Published: December 2024

The breast cancer is one of most prevalent cancer in women, and after lung cancer, it is the second greatest death cause in women. From previous years, progress has been made and continues to be made in the breast cancer vaccines development. It is a great approach to create hybrid compounds by combining distinct pharmacophores to gain important biological activity. The use of coumarin in conjunction with other themes has resulted in the creation of novel strategies to combat breast cancer. Coumarin has been shown in reviewed literature to be a potent antidote for breast cancer, binding to different biological targets linked to the disease. The hybrids of Coumarin have recently gained the notice of researchers who want to investigate their therapeutic potential in the treatment of breast cancer due to their minimal toxicity in multiple organ systems. Interactions with isoxazoles, thiazoles, monastrol, chalcone, triazole, sulphonamide, and other coumarin strains have been reported. The definitions of the different coumarin compounds, as well as their structural connections, are described in this review article.
VEGF as Alveolar Bone Regeneration Key Protein in SHED Secretome, Hydroxyapatite and Collagen Type 1 Scaffold: An In-Silico Study
Authors: Rachmawati Dini , Saskianti Tania , Devijanti Ridwan Rini , Prasetyaningrum Nenny , Kanawa Masami
Published: December 2024

Background: A combination of SHED secretome, hydroxyapatite, and collagen type 1 is a promising scaffold for the alveolar bone defect. IL10, VEGF, FGF2, and TGF-beta growth factors contained in SHED secretome can potentially increase bone regeneration, while HA and COL10A scaffolds bind bone tissue and stimulate osteoblasts in the bone formation process. However, the activity, interaction, and physicochemical factors of those growth factors need to be revealed to increase their potential in tissue engineering. Objective: This study aimed to decipher the molecular basis of SHED Secretome, hydroxyapatite, and collagen type 1 combination for identifying biomolecules that drive the alveolar bone regeneration process. Method: The Uniprot and PubChem databases collected protein and molecular data. Docking analysis using the STITCH and STRING webservers. Results: IL-10, VEGF, FGF-2, TGF-beta, COL10A1, and HA are known to be involved in the alveolar bone defect healing process. These proteins support each other's functions and are assumed to be essential in bone regeneration. The analysis results show that the VEGF protein has a high score of betweenness centrality and closeness centrality. This means that VEGF has the most frequent and efficient interactions with other proteins related to bone regeneration mechanisms. Meanwhile, the COL10A1 protein has the lowest score. It indicates the protein has low and limited interactions. Conclusion: The combination of SHED secretome and HA-collagen type I can potentially increase the bone regeneration process of the alveolar bone defect with VEGF as a critical protein because of its high interaction efficiency compared to other proteins.
Association between Hypertension and Endothelin-1 Protein Induced by Dyslipidemia: An In vitro and Epidemiological study in the Aceh Population
Authors: Desiana Desiana , Suhud Khairi , Zainal Abidin Muchlisin , A. Gani Basri
Published: December 2024

Dyslipidemia has been reported as a trigger for hypertension, which causes coronary heart disease and stroke.Several ethnic groups in Aceh, Indonesia, are reported to have different health statuses that trigger dyslipidemia.Aim.Evaluating the incidence of hypertension influenced by dyslipidemia factors in Aceh ethnic for the benefit of treatment and reducing the risk of hypertension.Tensimeter, LIPID PRO checked hypertension and endothelin-1 titer by ELISA and checked HDL, LDL, triglyceride, and total cholesterol levels.The subject population consisted of 81 men (53%) and 71 females (47%) who were spread across ethnic Aceh (64:42%), Gayo (52:34%), and AneukJamee(36:24%).The population of subjects suffering from hypertension with a history of cholesterol in the Acehnese dominates, followed by the AneukJamee and Gayo tribes.Generally, the moderate-risk hypertension category was the most common in both male (62%) and female (44%) groups.A high-risk type of dyslipidemia was found in males and females (69% and 73%, respectively). Hypertension is connected with elevated LDL cholesterol, total cholesterol, HDL cholesterol, and triglycerides among four of Aceh's ethnic groups.The highest average endothelin-1 level was in the AneukJamee race (3.48 pg/mL), followed by the Aceh race (2.26 pg/mL) and the Gayo race (2.18 pg/mL).Hypertension experienced by four ethnicities in Aceh is associated with the prevalence of dyslipidemia with increased LDL, total cholesterol, and HDL.In contrast, triglycerides have a lower relationship with the incidence of hypertension.Increased hypertension among ethnic Aceh, Gayo, and AneukJame correlates to increased endothelin-1 protein.
Development and Validation of Selective and Sensitive Liquid Chromatography - Tandem Mass Spectroscopy (UHPLC-MS/MS) Method for Bioanalysis of Remogliflozin in Rat Plasma
Authors: Patel Smit J. , Chauhan Bindiya , Shaikh Basheer , Chavan Priyanka , Khan Nadeem
Published: December 2024

Remogliflozin is an inhibitor of sodium-glucose cotransporter 2 inhibitors (SGLT-2) protein and plays an important role in the treatment and management of type-2 diabetes mellitus. In this study, a selective isocratic method was developed and validated using liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) for the determination of remogliflozin in rat plasma. Acetonitrile with formic acid was used as a precipitating agent. Chromatographic separation was achieved by using X select CSH Fluorophenyl (150 mm x 4.6 mm, 3.5 µm) column and 0.1% formic acid in milli-Q water (20%) and acetonitrile (80%), v/v as a mobile phase for isocratic elution method. Flow rate and injection volume were maintained at 0.7 mL/min and 10 µL, respectively. The validated method was linear in the range of 15– 2009 ng/mL with the lower limit of quantification (LLOQ) of 18 ng/mL. Also, the method was precise with a % CV less than 5.75 and accuracy within ±10% of nominal concentration. The method is accurate, simple, precise, and suitable for its application in further bioequivalence and pharmacokinetic studies.
Comparative Anti-inflammatory property of Sterol and Non-sterol Fractions from Amorphophallus campanulatus Roxb. tuber
Authors: P. Padmane Suhas , R. Manapure Sharad , A. Sawale Jyotiram
Published: December 2024

The plant Amorphophallus campanulatus Roxb. is found predominantly all over India and is used for numerous ailments as well as for anti-inflammatory property as traditional medicine. In this study, we have done fractionation of sterol from chloroform and petroleum ether extracts and after fractionation the sterol fractions from petroleum ether (IC1), sterol fraction from chloroform extract (IC2), non-sterol fractions left after fractionation of chloroform extract (EX2) and petroleum ether extract (EX1) were subjected for anti-inflammatory study. In this experimental in vivo study, five groups were formed, consisting of albino rats weighing 200-250g, regardless of sex, each group comprised five animals. EX1, EX2, IC1, and IC2 extracts were given orally at a dose of 250mg/kg of body weight, 250mg/kg, 50mg/kg, and 50mg/kg respectively. The right hind paw was injected with 0.1ml of 1% carrageenan an hour later, and the paw volume was assessed one, three, and five hours later. Indomethacin was used as the reference standard. Sterol fractions (IC1 and IC2) showed significant anti-inflammatory activity at a dose 50mg/kg body weight compared with the indomethacin at 10mg/kg body weight; the non-sterol fraction did not demonstrate any anti-inflammatory property. When compared to indomethacin as a reference, it was determined that only the sterol fractions, IC1 and IC2, exhibited substantial anti-inflammatory effect. It demonstrates the strong anti-inflammatory property of A. campanulatus, which may be because of the presence of sterol.
DEMOGRAPHIC PROFILE OF ORAL LICHEN PLANUS PATIENTS IN THE BULGARIAN POPULATION. CLINICOPATHOLOGICAL CORRELATION IN THE DIAGNOSIS OF THE DISEASE
Authors:   Department of Periodontology and Oral Mucosa Diseases, Faculty of Dental Medicine, Medical University of Plovdiv, Bulgaria., Mutafchieva Maria
Published: December 2024

Oral lichen planus (OLP) is a relatively common mucosal disease that mainly affects middle-aged women, yet the epidemiological characteristics of this condition in the Bulgarian population are poorly studied. OLP is considered a clinic-pathological diagnosis that is sometimes challenging to make.
Aim. The aim of the present study was to determine the prevalence of OLP among the Bulgarian population and to evaluate the clinico-pathological correlation in the diagnosis of the disease.
Materials and Methods. The files of the patients with diseases of the oral mucosa consulted in the Department of Periodontology and Oral Mucosa Diseases, Medical University of Plovdiv, between 2012-2016, were retrospectively reviewed. A comparison was also made of the clinical and histopathological diagnoses retrieved from the archived pathohistological records for the same cohort of patients.
Results. Out of a total of 714 patients with mucosal diseases, 141 have been diagnosed with OLP, with the disease accounting for the largest proportion (20%) among the analyzed group. Male to female ratio was 1:4, and most patients were over 51 years of age. Histological confirmation of the clinical diagnosis OLP has been obtained in 84.1%, and there were additional 10.84% ​​cases with a histological diagnosis of OLP that were clinically misdiagnosed.
Conclusion. OLP seems to be of great clinical importance in our country. There is a clinic-pathological discrepancy in the diagnostic evaluation of the disease in a relatively high percentage of cases. Therefore, stricter diagnostic criteria need to be introduced and followed to obtain a more reproducible diagnosis of OLP.
Pengembangan E-Book Cerita Anak Model Tarl Bermuatan Kearifan Lokal untuk Meningkatkan Literasi Dasar Siswa pada Level Kemampuan Membaca Cerita
Authors: Syarifuddin Syarifuddin , Ahyar Ahyar
Published: December 2024

Penelitian ini bertujuan untuk mengembangkan e-book model TaRL berbasis konten kearifan lokal untuk meningkatkan kompetensi literasi dasar siswa. Tujuan penelitian ini adalah untuk mengetahui proses pengembangan dan kelayakan produk yang dikembangkan menggunakan metode R&D dengan model ADDIE. Penelitian ini dilakukan di SDN Inpres Rabakodo, Kecamatan Woha, Kabupaten Bima, Provinsi Nusa Tenggara Barat. Subjek penelitian ini adalah siswa kelas V SDN Inpres Rabakodo sejumlah 20 orang. Pengumpulan data menggunakan angket. Validator pertama sebagai ahli materi memberikan skor total 17 dari 20 (85%), validator kedua sebagai ahli media memberikan skor total 20 (100%) dan validator ketiga (guru dan praktisi pendidikan) memberikan skor total 40 dari 40 (100%) sehingga persentase rata-rata kelayakan sebesar 95% (sangat tinggi). Dengan demikian, e-book yang dikembangkan dapat digunakan untuk meningkatkan kompetensi literasi dasar siswa pada jenjang membaca cerita.
Climate change and health: Hidden threats and sustainable prospects
Authors: Al-Enazi Huda Awad , Alshaghroud Salah Mohammed , Altwaijri Saleh Abdullah , Alrashed Mohammed Abdulrahman , Alotaibi Adil Mubarak F , Alahmadi Fahad Sale M , Almarzuqi Adhah Zabbar H , Alharbi Sami Sunaid , Alshammari Mohammed Salem , Aljohani Mazen Dakhel Saleh
Published: December 2024

Background: Climate change is becoming a bigger problem around the world that has big effects on people's health. Direct effects on health, like heatwaves and worsening air quality, are well known. But hidden threats, like the rise of vector-borne diseases, food shortages, and mental health problems, have not been fully studied. These threats affect vulnerable groups more than others, making health disparities worse. To deal with these problems, we need long-term, diverse solutions that boost robustness and lower risks. Aim: The point of this study is to look into the hidden health risks that climate change poses and to look at long-term ways to lower these risks, with a focus on improving global health equality and resilience. Methods: Findings from peer-reviewed journals, world health records, and climate change reports are put together in this study. Case studies of areas that have been impacted and data breakdowns are used to show how climate change and health are connected in a complicated way. Green healthcare systems, neighborhood resilience programs, and global policies are some of the sustainable solutions that are looked at in detail.
Natural convection within a greenhouse cavity with a porous layer mimicking algerian soil heated by embedded hot pipes: effects of soil porosity and permeability
Authors: Brahmi Chihab Eddine , Battira Mouna Maache , Belghar Nourredine
Published: December 2024

This study numerically investigates geothermal performance in selecting optimal soil properties for greenhouse applications. The analysis considers steady free convection within a two-dimensional cavity partially filled with a porous layer and featuring three embedded hot pipes beneath a semi-elliptical upper boundary, representing a greenhouse structure. The numerical simulation employs the Galerkin finite element method. The cavity is subjected to a hot isothermal temperature Th along the heated pipes and a cold isothermal temperature Tc on the top wall. Momentum transfer in the porous medium is modeled using the Darcy-Brinkman approach, incorporating non-Darcian flow effects. Key parameters explored include Rayleigh numbers (104<Ra<106), Darcy numbers (Da= 10-4 and 10-2), and porosities (ε=0.2 to 0.5). Results reveal that heat transfer significantly increases with higher Rayleigh numbers, while the effect of porosity is minimal. However, increased permeability and higher Darcy numbers substantially enhance heat transfer, particularly at elevated Rayleigh values.
Evaluation of the antifungal and antibacterial activities of plant extracts of the genera Centaurea papposa red and Punica granatum L belonging to the family Asteraceae and Lythraceae
Authors: Ababsa Zine El Abidine , Souilah Nabila , Bellil Ines
Published: December 2024

Centaurea papposa and Punica granatum L are plants belonging to the Acteracea and Punicacea families, respectively, and their richness in secondary metabolites led us to extract the leaves using methanol; the methanolic extract is then fractionated using solvents of increasing polarity. Based on these data, we were interested in the biological study and evaluation of two biological activities of these plants. Firstly, we studied the antibacterial activity on five bacterial strains (Bacillus subtilis, staphylococcus aureus, Esherichia coli, Proteus vulgaris, Pseudomenas aeruginosa). This activity was carried out using the diffusion method on disks impregnated with different concentrations of the extract. The results show that the dichloromethane extract of Centaurea papposa is the most active on the strains tested, with a maximum inhibition diameter of 15 mm for the initial concentration (MS) against Proteus vulgaris. Meanwhile, the n-butanol extract of Punica granatum L has the best antibacterial power against staphylococcus aureus with a diameter of 26.5 mm. On the other hand, we evaluated the antifungal activity on three fungal strains (Fusarium culmorum, Fusarium oxysporum, Fusarium cerealis) by the well diffusion method and the results show that the strains are very sensitive to three extracts with significant areas of inhibition.
Papel do familiar no processo de tomada de decisão das diretivas antecipadas de vontade em situações de fim de vida
Authors: Silva Elizabeth Pimentel da , Frutuoso Rafael Esteves , Costa Cristiane Maria Amorim
Published: December 2024

As diretivas antecipadas de vontade (DAV) são uma manifestação livre e prévia na qual uma pessoa, com capacidade e discernimento, recupera, ou mantém a qualidade de agente na tomada de decisões sobre a assistência que deverá ou não ser realizada durante sua inaptidão. O propósito deste estudo é identificar e analisar produções acadêmicas voltadas ao processo de tomada de decisão sobre DAV na perspectiva de familiares de pessoas em situação de fim de vida. Trata-se de uma revisão integrativa da literatura realizada nas bases de dados LILACS, MEDLINE, Web of Science, SciELO e Scopus, tendo sido selecionados 17 artigos. Como resultados principais, foram identificados aspectos limitantes para exercício das DAV, como hiatos de informação, comunicação e discussão em tempo hábil sobre essas diretivas, o que tende a ocasionar conflitos, principalmente na ausência de um mandatário substituto. Observou-se também a importância não só do amparo legal, mas da divulgação do tema na sociedade. Como fatores facilitadores, constatou-se que quando a família é bem esclarecida, ela se torna a maior incentivadora das DAV e mediadora da assistência prestada; os estudos indicaram ainda a relevância cultural na abordagem. Desse modo, os achados apontaram a importância da participação da família para garantir o protagonismo do paciente nas decisões acerca do cuidado, respeitando sua dignidade e autonomia, bem como mostraram a relevância da decisão compartilhada como guia no tratamento do tema.
Estudo da matemática financeira e educação financeira: aproximações e diferenças
Authors: Araujo Weslay Vieira de , Cardozo Daucília Araújo , Sousa Tiago Camelo , Araujo Kécia Silva , Santos Davi Ribeiro dos , Cole Bruno Salgado , Brito José Marcio Machado de , Lustosa Iuri Augusto Alves
Published: December 2024

O presente trabalho tem por objetivo abordar as aproximações e diferenças entre a Matemática Financeira e a Educação Financeira, além de explanar de forma sucinta sobre ambos os temas e ressaltar a importância de trabalhar com tais assuntos nas escolas, uma vez que pode vir a contribuir para a qualidade de vida financeira de muita gente. A fim de mostrar a relevância e a necessidade em conhecer conceitos da Matemática Financeira bem como da Educação Financeira buscou-se embasamento em autores e pesquisadores como Puccini (2011), Castro e Dal Zot (2015), Lopes (2018), Pinto (2020), entre outros. Além de livros e artigos, também foram analisados sites que tratam da Matemática Financeira e da Educação Financeira, dando maior visibilidade às temáticas. É perceptível que a Matemática Financeira é abordada de forma mais ampla nas escolas do que a Educação Financeira, visto que a abordagem dos dois temas se faz necessário para que as pessoas tenham um melhor direcionamento quanto as suas tomadas de decisões no que diz respeito as suas finanças. O ensino e aprendizagem da Educação Financeira aliada a Matemática Financeira tem muito a contribuir na qualidade de vida das pessoas, seja individualmente ou de forma coletiva, desta forma o ensino de Educação Financeira vem acontecendo de forma transversal nas salas de aula, um grande passo para o incentivo de consumidores mais conscientes.
Rearranjo genético do vírus OROV BR-2015-2024 e a associação com o surto de febre oropouche
Authors: Teixeira Jeferson Manoel , Barbosa Iná Regina Talacimon , Araújo Maísa Bandeira , Praça Luiz Felipe de Albuquerque Mundim , Camillato Marina Carvalho Fracalossi , Costa Lidiane Batista da , Monteiro Tiago da Cruz , Souza Ivaldo Maurício de , Sousa Neilton Nogueira de , Costa Fabio Alexandre , Mendes Rogério de Oliveira , Stocker Hilton Diego de Paula , Brito Leonardo Rodrigues , Silva Filho Leonardo Cézanne Garcia da , Guerra Murilo de Almeida Araujo , Barbosa Erick Matheus Garcia
Published: December 2024

A epidemia de febre Oropouche no Brasil, entre 2015 e 2024, revela um aumento significativo nos casos, associada ao rearranjo genético do vírus Oropouche (OROV). Essa doença, transmitida principalmente pelo vetor Culicoides paraensis, porém outros vetores podem estar envolvidos na transmissão como Culex quinquefasciatus, apresenta manifestações clínicas que vão de sintomas leves a complicações graves, como quadros neurológicos e hemorrágicos. Esta patologia foi negligenciada por anos, e atualmente, ela está requerendo uma atenção especial a nível mundial, de todas as autoridades competentes, pois o tema além de se enquadrar em medicina tropical, há relevância para saúde única. O impacto das mudanças genéticas do OROV sugere uma adaptação que pode aumentar a transmissibilidade e a virulência do vírus. A abordagem de saúde única se torna crucial, considerando a interdependência entre saúde humana, animal e ambiental, especialmente em contextos de desmatamento e mudanças climáticas. Medidas integradas de vigilância, diagnóstico e educação em saúde são essenciais para o controle da epidemia e a proteção da saúde pública.
Art Development in Authoratitive Governments
Authors: Li Jialin
Published: December 2024

This paper takes the development of comic art in China as the research object, aiming to demonstrate the influence of authoritarian political system on the development of art. First, it introduces the three art forms of Chinese comics: satirical comics, comic strips and modern story comics, and summarizes the development characteristics of Chinese comics during the Cultural Revolution and the influence of China's planned economy. Secondly, from the development of comics in the late Cultural Revolution in China and the development of comic art in the liberal democratic environment of the West, it explores the influence of political system and economic policy on the development of art.
Acculturation of Images in American and Chinese Poetry
Authors: He Shi
Published: December 2024

The people who speak English and Chinese respectively live on the same planet for thousands of years. They share same feelings and perceptions toward the things about themselves and around them during the course of human evolution. Some Chinese theories attracted attention in Western world because they share common ground with certain traditional Chinese literary concepts. Poetry is the soul of literature. This thesis will discuss the backgrounds of acculturation of images in American and Chinese Poetry.
Quota Allocation Policy in Carbon Market Trading -- A Case Study of Beijing and Shenzhen
Authors: Yang Xiaotian
Published: December 2024

With the increasingly serious problem of the greenhouse effect and climate change, the concept of a carbon emission market has been gradually included in the development agenda of various countries. Establishing carbon markets is expected to promote energy conservation, emission reduction, and green development of multiple industries. In 2021, China's carbon market officially launched, entering a new stage of development. This paper aims to take Beijing and Shenzhen, two pilot cities approved in advance, as examples to study the allocation of credits in the Chinese carbon market. through the literature research method, content analysis method, and comparative analysis method, combined with existing literature to carry out specific analysis and comparison of quota allocation in these two cities. Through the above analysis, this paper aims to get a clearer and deeper understanding of the current situation, distribution mode, distribution method, and characteristics of local Allocation of emission credits relating to the following activities in the actual situation. It helps us to grasp the existing problems and defects in the carbon quota allocation of the two cities. It provides reference significance for promoting the development of Beijing, Shenzhen, and the overall carbon market in China.
Investment Research on Individual Stocks in Large Research Industry Enterprises
Authors: Zhang Xuan
Published: December 2024

As technology continues to develop, the influence of the technology industry on the market cannot be ignored. This study aims to explore the trends and fluctuations of key representative technology stocks, specifically focusing on Advanced Micro Devices (AMD), Oracle Corporation (ORCL), and Qualcomm Incorporated (QCOM). By meticulously analyzing the publicly available balance sheets and income statements of these companies, we will extract pertinent financial indices and conduct a comprehensive financial analysis. The analysis will include key financial metrics such as revenue growth, profit margins, return on equity (ROE), and debt-to-equity ratios, among others. These metrics will be used to evaluate the financial health and performance trends of each company over a specified period. Additionally, we will compare these metrics across the three companies to provide insights into their relative market positions and competitive advantages. The objective of this analysis is to furnish investors with a reliable and data-driven market analysis that can inform their investment decisions. By understanding the financial underpinnings of these technology giants, investors can better assess the potential risks and returns associated with investing in these stocks. This study aims to bridge the gap between financial theory and practical investment strategies, offering a valuable resource for both individual and institutional investors interested in the technology sector.
Optimization Study of High-Efficiency Rectifier Circuits for Uninterruptible Power Supply Systems
Authors: Fan Yulu
Published: December 2024

Uninterruptible Power Supply (UPS) is a kind of equipment that can supply power to other equipment’s in an uninterrupted way, which can ensure that the key equipment’s can continue to operate stably in the face of power grid failure. Therefore, uninterruptible power supply system is of utmost importance in the modern power system. The aim of this paper is to optimize rectifier circuits in uninterruptible power supply system that rely on three-phase bridge full-wave rectifier circuits. Build a model using LTspice and simulate it, compare and analyze the waveform characteristics of the output voltage of the load under different filtering schemes, and propose optimization strategies based on actual production. As one of the key components of the UPS system, the rectifier circuit can directly affect the efficiency with stability of the whole system. Hence, it is important to optimize the high efficiency rectifier circuit to improve the overall performance of the UPS system.
YOLOv10-based Model for Player and Football Detection
Authors: Hu Erzhizhi
Published: December 2024

This study presents an advanced YOLOv10n-based method for the automatic detection of football players and balls directly from match videos. We enhance the YOLOv10 architecture with several significant improvements, including additional detection heads, the integration of C2f_faster and C3_faster modules for enhanced processing speed and accuracy, and the inclusion of BotNet modules with self-attention mechanisms for managing complex visual scenes. Further, we incorporate GhostConv modules to reduce computational overhead while maintaining effective feature extraction. These architectural modifications ensure robust detection capabilities in real-time sports environments, addressing challenges such as high-speed movements, frequent occlusions, and variable lighting conditions typical of both indoor and outdoor stadiums. Validation on internet-sourced images from football matches demonstrates the practicality and effectiveness of our model.
Prediction and Evaluation of Investment Portfolios Using Multi-Factor Models: A Case Study of Engineering & Construction and Insurance-Reinsurance Industries
Authors: Fan Yiqiang
Published: December 2024

This analysis evaluates the performance of a portfolio selected from 20 common stocks across two industries: Engineering & Construction and Insurance-Reinsurance, covering period from 2020 to 2023. By utilizing historical data, a rigorous multi-factor approach is employed to assess the financial return and risk characteristics of the assets. Key metrics include the stocks and the total portfolio return and risk. These metrics provide empirical insights into the performance of the portfolio.
Investing In High Technology: Strategies for International Financial Markets
Authors: Xie Kaying , Tang Naze , Chen Yuyue
Published: December 2024

With the development of the world, the connection between the international financial market and the high-tech industry is becoming increasingly close. The innovation and development of the high-tech industry has not only promoted the adjustment and upgrading of the global economic structure, but also injected new vitality and opportunities into the international financial market. The theme of the research is to explore investing strategies of the high technology industry in the international financial market. Through the collection and analysis of relevant literature, the selection of typical cases for in-depth research, the processing and analysis of the collected data. After research, we have come to the following main results, the development trend and prospects of the high-tech industry have great development potential. Changes in the international financial market will have an important impact on investment in the high-tech industry. Investors investing in high-tech industries in the international financial market need to develop effective investment strategies and methods. This study argues that investment in the high-tech industry is of great strategic significance in the context of the international financial market. Investors should pay close attention to the development trends and prospects of the high-tech industry, as well as the changes in the international financial market, and formulate effective investment strategies and methods.
Digital Bridge: The Role and Function of Youth Social Organizations in the Construction of Digital Villages
Authors: Wang Qi , Li Huizhong
Published: December 2024

Against the background of the continuous advancement of global informatization, the construction of digital villages has become an important strategy to promote rural revitalization and agricultural modernization. This paper explores the roles and functions of youth social organizations in the construction of digital villages through discursive and documentary analysis methods, focusing on how these organizations can play a key role in influencing the process of rural digitization through their dynamism, innovative capacity, and commitment to the public interest. The aim of this paper is to assess the roles and contributions of youth social organizations and explore how to optimize their role in this field.
The Boundaries of Directors' Duty of Diligence: Responsibility Determination from the Perspective of Corporate Decision-Making Mechanism
Authors: Wang Jiachun
Published: December 2024

Although China's Company Law has established a basic framework for the duty of care of directors, there is still a lack of clear and specific standards for the boundaries and responsibility determination of the duty of care under the decision-making mechanism in the specific implementation process. This involves disputes over the allocation of corporate decision-making power and the choice of judgment criteria. The choice should be made based on the company's objective reality. Examining the composition of the elements of responsibility, subjectively it should be gross negligence and non-bona fide, and objectively, when evaluating whether the director has been diligent, one should not simply judge from the outcome, but should delve into the considerations and efforts in the decision-making process to fairly evaluate whether the director has fulfilled their duty of care. The business judgment rule essentially reduces the requirements of the duty of care for directors and serves to block liability. Therefore, the determination of responsibility should be lenient rather than strict. By constructing a scientific, reasonable, and flexible determination mechanism, the optimization and upgrading of corporate governance are promoted.
A Review of The Research on the Implementation Effect of Inclusive Financial Policies in China
Authors: He Meilin
Published: December 2024

The inclusive financial policy aims to address the financial needs of the vulnerable, such as small and micro enterprises (SMEs), farmers. The Chinese government places significant emphasis on the advancement of inclusive finance, and this paper employs a literature review method to demonstrate the positive effects of inclusive financial policies and digital inclusive finance (DIF) in the areas of small and micro enterprise financing, rural revitalization, urban development, real economy, and virtual economy.
A Comprehensive Analysis of The Retail Giant: An In-Depth Study of Costco
Authors: Zhao Haoyan
Published: December 2024

As a leader in the US membership-based warehouse retail chain, Costco provides consumers with high-quality and low-price goods through high-volume procurement and a streamlined supply chain and cultivates a loyal customer base through the membership fee model. This study provides an in-depth analysis of Costco's market performance, competitive advantages, SWOT analysis, and risk assessment to evaluate the company's operating conditions and development prospects comprehensively. The financial data shows that Costco's revenue continues to grow, and profitability is solid. However, it still faces increasing competitive pressure from online retailers and risk factors such as economic volatility and supply chain disruptions. According to the study, Costco should actively invest in digital transformation, explore multichannel retail strategies, and focus on expansion opportunities in emerging markets. At the same time, companies must continue to focus on cost control and operational efficiency and strengthen cybersquatting and sustainability initiatives. Through internal and external training, Costco can consolidate its leading position in the retail industry, navigate the rapidly changing market environment, and achieve long-term stable growth. Based on empirical analysis and case studies, this study aims to objectively evaluate Costco's strengths and weaknesses and provide reference suggestions for its future development.
The Persuasiveness of the Flu Vaccination Campaign Video
Authors: Tong Jiaxin
Published: December 2024

The purpose of this paper is to evaluate the effectiveness and persuasiveness of the health campaign video about flu vaccinations called No Time For Flu: 30. A survey that asks for people’s attitudes before and after watching the video, targeted to those people who haven’t taken the flu vaccines yet. Twenty-six participants were involved in the survey, including six males and twenty females. After watching the video, the result shows no significant change in people’s attitudes toward taking the flu vaccines. However, it helps raise people’s awareness of flu shots. Failure of the persuasive message designs of “gain-framed message,” “source similarity,” and “peripheral path” might contribute to the ineffectiveness of the video in persuading people. In future health promotion campaigns, to persuade people to take action, persuasive message designs like “loss-frame message” might be suggested for effectiveness. For future research in measuring the effectiveness of persuasive message design in health promotion campaigns, higher numbers of participants with broader races and occupations are suggested. Also, designing the survey in different periods of time for more generalizable results is recommended as well.
Federated learning merges with v2x privacy protection
Authors: Zhou Yuhan
Published: December 2024

Vehicle-to-Everything (V2X) communication systems are poised to revolutionize road safety, traffic efficiency, and driver experience through real-time data exchange among vehicles and infrastructure. However, ensuring the privacy and security of sensitive vehicular data remains a critical challenge. Federated Learning (FL) emerges as a promising paradigm to address these concerns by enabling collaborative model training without centralized data aggregation. This paper explores the integration of FL techniques into V2X environments, where vehicles act as decentralized participants in model training processes. We discuss the unique challenges and opportunities presented by V2X scenarios, such as intermittent connectivity and diverse data distributions across vehicles. Through a detailed review of existing FL methodologies and their adaptation to V2X settings, this paper proposes practical solutions for privacy-preserving model aggregation and efficient learning across dynamic vehicular networks. Case studies and simulation results illustrate the feasibility and benefits of FL in enhancing V2X applications while safeguarding user privacy. This study contributes to the growing field of secure and collaborative machine learning in connected vehicle environments, paving the way for safer and smarter transportation systems.
A Comprehensive Analysis on CMOS Comparators: Principles, Design Optimizations, and Applications
Authors: Zeng Zixi
Published: December 2024

The paper aims to systematically review the basic principles, structure, and optimal design of Complementary Metal Oxide Semiconductor (CMOS) comparators, discussing their specific applications in various fields and their future development trends. CMOS comparators are crucial in signal processing and data conversion due to their low power consumption and high integration capability. The paper begins with an introduction to the basic principles and technical analysis of CMOS comparators, providing a foundation for understanding their operations. It then explores the detailed structure and optimization design of both traditional and new CMOS comparators, highlighting advancements in speed and power efficiency. The paper concludes with an analysis of performance optimization techniques, including device parameter adjustments and deep learning-based optimizations, and discusses the integration and packaging trends that will shape the future of CMOS comparators. This comprehensive review of CMOS comparators summarizes current knowledge and advancements, making it a valuable resource for researchers and engineers. It highlights key developments in speed, power efficiency, and integration, and discusses future trends and optimization techniques. This work contributes to the continued innovation of electronic systems, enhances signal processing capabilities and guides future research directions.
A Study on the Impact of Cultural Difference Awareness on Opportunity Recognition in Entrepreneurship Among International Students in China
Authors: Shi Tao , Zhang Zhongyong , Huang Caixia , Chi Bengrui
Published: December 2024

Supporting the development of international students in China can help to promote economic growth and Chinese culture, as well as the consolidation of the “Belt and Road” construction process and international exchanges. This paper utilizes the rootedness theory to investigate the impact of cultural differences in cognition on the identification of entrepreneurial opportunities for international students from countries along the “Belt and Road” through field interviews with several international students from these countries. The study found that: (1) The level of cultural difference awareness directly and positively affects the identification and utilization of entrepreneurial opportunities by international students. (2) Communication effectiveness plays a mediating role in the process of cultural difference cognition on the identification of entrepreneurial opportunities by international students. (3) The external carriers of cultural difference awareness of international students in China include the Chinese dining table culture, trade habits, and social etiquette, and the internal factors are mainly in the personal cultural interaction, emotional experience, and adaptation to the Chinese culture. This study reveals the key role of cultural difference awareness in the identification of entrepreneurial opportunities for international students in China, which can help international students discover unique business opportunities through adapting to Chinese culture, and promote talent retention and economic development in China.
A Study on the Shaping of Students' Self-Efficacy by Teachers' Feedback Styles in the View of Educational Psychology
Authors: Zhang Juan
Published: December 2024

This study explores the shaping of students' self-efficacy by teachers' feedback styles from the perspective of educational psychology. The classification and characteristics of teachers' feedback styles are analyzed, including conversational descriptive feedback, different types of feedback, self-referential and other-referential feedback, and SHARP feedback method. The concept and importance of students' self-efficacy and the relevant theoretical foundations in educational psychology, such as Bandura's social cognitive theory and Locke's goal-setting theory, are described. The relationship between teachers' teaching efficacy and students' self-efficacy was investigated, and teacher feedback strategies for cultivating students' self-efficacy were proposed, including giving positive feedback and recognition, encouraging to try new things, and providing a suitable learning environment. Finally, we summarize the research results and point out the shortcomings and prospects of the study. In the future, we can further study the relationship between teachers' feedback and students' self-efficacy in different cultural backgrounds and digital environments, and expand the research targets and incorporate more theories of educational psychology.
An Analysis of Key Macroeconomic Factors Driving Chinese Tourism Demand for South Korea
Authors: Li Wenqing , Zhang Weiran , Duan Keyang
Published: December 2024

This study employs a random effects model to examine the macroeconomic factors that shape Chinese tourism demand for South Korea. Key drivers identified include per capita income, exchange rates, and the consumer price index (CPI). As Chinese incomes rise, there is a notable shift towards more premium travel destinations, which may result in decreased demand for South Korea. Exchange rate fluctuations, though significant, have not meaningfully stimulated tourism, potentially due to non-economic factors such as geopolitical tensions. In contrast, rising CPI in South Korea has not negatively impacted its appeal, indicating that other elements, such as cultural attractions and service quality, may offset price increases. Additionally, trade volume between China and South Korea contributes to shaping demand, highlighting the complex interplay between economic activity and tourism. These findings offer valuable insights for policymakers seeking to strengthen the China-South Korea tourism market by addressing income distribution, exchange rate stability, and enhancing non-price factors in tourism promotion strategies.
Research On the Impact of ESG Performance on Operating Capacity in Environmental Protection Industry
Authors: Chen Yiou , Yu Tianyuan
Published: December 2024

With the rise of ESG concepts as a hot topic, the topic of corporate Environment. Social. Government(ESG)governance has attracted the attention of scholars. However, there is a lack of research on the relationship between corporate ESG governance and operational capabilities. This article explores the impact and mechanism of ESG performance of listed companies in the environmental protection field on their operational capabilities. Based on quarterly data from 2010 to 2023, this article uses the Topsis model and linear regression analysis to do empirical analysis. Research shows that the comprehensive ESG performance of environmental protection enterprises is significantly positively correlated with their operational capabilities. Enterprises with excellent ESG can improve operational efficiency by effectively reducing sales costs. The study emphasizes the role of ESG in corporate strategy, information transparency, and financing simplification, and suggests that companies strengthen the integration of ESG strategies into their business, transparent disclosure, and internal and external supervision. This article enriches the research on the operational efficiency of ESG in environmental protection enterprises and has practical guidance value for ESG application, policy formulation, and corporate strategy.
Leveraging Machine Learning Algorithms for Early Detection and Prediction of Dengue Fever
Authors:   Faculty of Artificial Intelligence, Delta University for Science and Technology, Mansoura, Egypt, Marwa Marwa ,   School of ICT, Faculty of Engineering, Design and Information  Communications Technology (EDICT), Bahrain Polytechnic, Isa Town, Bahrain,   School of ICT, Faculty of Engineering, Design and Information  Communications Technology (EDICT), Bahrain Polytechnic, Isa Town, Bahrain, Gatzoulis Christos , Abedallat Osama Al
Published: December 2024

This paper explores the potential of machine learning (ML) in revolutionizing the screening and prognosis of dengue fever, a pervasive viral illness transmitted through the bite of infected mosquitoes prevalent in tropical and subtropical areas. Historically, traditional approaches to monitoring outbreaks have been hampered by a lack of precision and timing, creating an opportunity for machine learning to rectify datasets and uncover patterns that enhance accuracy. The paper introduces Random Forests, Support Vector Machines, Neural Networks, and combined classification models, along with their advantages, disadvantages, and the potential for incorporating external data such as climatic factors, population data, real-time Twitter data, etc. The results demonstrate significant increases in accuracy from the models, but it is clear that their applicability is contingent on localized approaches suitable for the regions. This underscores the importance of the quality and completeness of data used in the models. Current research indicates that data availability and the refinement of these models require a collective approach. The work underscores the potential of ML to redefine the paradigm of outbreak management in dengue and other vector-borne diseases, offering hope for improved public health worldwide.
דבר המערכת, חורף תשפ"ה
Authors: הלר ערגה
Published: December 2024

קוראים יקרים,

כוחו של החינוך בתקופות כמו זאת העוברת עלינו, לצערנו, מאז סוף חגי תשרי תשפ"ד נמדד ביכולתו לקיים שגרה, גם אם שגרה חדשה של חיזוק, תמיכה ותקווה. ערכים רבים שהגיעו למערכת בחודשים האחרונים ועתידים להתפרסם בחלקם בשני הגיליונות הבאים משקפים את האתגרים הנוכחיים של מערכות החינוך בישראל.

תקופות משבר, מלחמה ואובדן, כפי שלמדנו לאורך תולדות העם והמדינה, הן גם תקופות של כינון ערכים ושימור מסורות באמצעות סוכני התרבות הקרובים ביותר לילדים ובהם המורים וצוותי החינוך. כך, מבלי שהתכוונו, ואף על פי שחלק מהערכים נמצאו בתהליכי קבלה ושיפוט מלפני אוקטובר 2023, נראה כי גיליון 22 של כתב העת לקסי־קיי סובב תמות של תקווה, אחווה ורווחה.
Evaluación comparativa entre los perfiles de disolución de tabletas de Clorhidrato de Propranolol genéricas del mercado Venezolano y el Importado
Authors:   Laboratorio de Análisis de Medicamentos, Facultad de Farmacia UCV. Correspondencia: Apdo. 40109 - Caracas 1040A, Venezuela, Agudelo Janesky
Published: December 2024

Se realizó un estudio comparativo de perfiles de disolución de clorhidrato de propranolol 40 mg en tabletas. La comparación se realizó entre un medicamento genérico importado contra un producto de referencia genérico nacional, en medios de disolución a diferentes pH y en agua desionizada. Este principio activo pertenece a la clase 1 del Sistema de Clasificación Biofarmacéutica (SCB), posee una alta solubilidad y alta permeabilidad, lo que permite realizar un estudio de bioexención como una posible alternativa a un estudio de bioequivalencia, con la finalidad de determinar si existe similitud entre ambos medicamentos. Se encontró que los perfiles de disolución entre ambos fármacos son similares, donde no existe diferencia significativa entre ellos. Sin embargo, al realizar el ensayo de valoración y uniformidad de contenido, el producto de origen importado no cumple con las especificaciones consultada en la literatura.