bluuebunny/crossref_metadata_2025 huggingface dataset:
Modulation of Multichannel Electronic Communication Signal Parameters Based on a Nonlinear Phase Principle
Authors: Zhao Lifang
Published: August 2022

In order to solve the difficulty of the optical fiber communication system and network as the infrastructure of the global communication network, which is faced with the requirement of large capacity and high speed, the author proposes a method to modulate the parameters of multichannel electronic communication signals based on the nonlinear phase principle. The method includes multichannel electronic communication signal search, multichannel electronic communication signal parameter modulation, and multichannel electronic communication signal automatic acquisition algorithm realization. Experimental results show that under the conditions that the sampling frequency is set to

f
=
8.145

 MHz, the length of the C/A code period is set to 1 ms, and the 1 ms data packet contains 8145 sampling points, under the same experimental conditions, the capture probability of this experiment reaches 100% and the traditional algorithm has a capture probability of up to 70%. Modulation of multichannel electronic communication signal parameters based on nonlinear phase principle has a positive guiding role in building a high-speed optical fiber communication system and network with long distance, large capacity, high elasticity, high reliability, and low delay.
[Retracted] On the Problems and Countermeasures of College Students’ Mental Health and Safe Work under Network Environment
Authors: Xu Yuanyuan , Liu Shuchao , Chen Yongdong
Published: August 2022

Under the network environment, mental health and safety work on college is related to national security and campus security. Moreover, it affects the healthy development of college students. In the era of ever‐changing mobile Internet, colleges and universities must take practical countermeasures against the problems in mental health and safety education on college and improve the relevance and effectiveness of college students’ network safety education. This paper first finds the problems of college students’ mental health and safety through questionnaire survey and analyzes the current situation of college students’ mental health and safety under the current networked environment. In response to the problems found, we propose complete and systematic educational countermeasures. At the same time, we need to firmly establish the strategic awareness of network security education and strengthen the construction of network security education in colleges and universities. We should strengthen the construction of network security education in colleges and universities, form a joint effort of schools, families, government, and society, and improve the quality and effectiveness of network security education.
Biogenic Selenium Nanoparticles Alleviate Intestinal Epithelial Barrier Damage through Regulating Endoplasmic Reticulum Stress-Mediated Mitophagy
Authors: Qiao Lei , Yan Shuqi , Dou Xina , Song Xiaofan , Chang Jiajing , Pi Shanyao , Zhang Xinyi , Xu Chunlan
Published: August 2022

The intestinal barrier plays a fundamental role in body health. Intracellular redox imbalance can trigger endoplasmic reticulum stress (ERS) and mitophagy, leading to intestinal barrier damage. Our previous studies demonstrated that mitophagy is closely associated with the protective effects of biogenic selenium nanoparticles (SeNPs) on intestinal epithelial barrier function. Thus, we hypothesize that ERS and mitophagy are likely involved in the regulatory effects of SeNPs on oxidative stress-induced intestinal epithelial barrier dysfunction. The results showed that oxidative stress or ERS caused the increase of intestinal epithelial permeability. SeNPs effectively alleviated hydrogen peroxide (H2O2-)-induced structural damage of endoplasmic reticulum (ER) and mitochondria of porcine jejunal epithelial cells (IPEC-J2). SeNPs significantly decreased intracellular inositol triphosphate (IP3) and Ca2+ concentration, down-regulated inositol trisphosphate receptor (IP3R) expression level, and up-regulated ER-resident selenoproteins mRNA levels in IPEC-J2 cells exposed to H2O2. In addition, SeNPs pretreatment significantly decreased the intracellular Ca2+, IP3, IP3R, and reactive oxygen species (ROS) levels; protected the structure and function of ER and mitochondria; and effectively alleviated the increase of intestinal epithelial permeability of IPEC-J2 cells exposed to tunicamycin (TM). Moreover, SeNPs significantly inhibited the colocalization of mitochondria and lysosomes. Furthermore, compared with TM model group, SeNPs significantly inhibited the activation of PERK/eIF2α/ATF4 and AMPK/mTOR/PINK1 signaling pathway. The PERK agonist (CCT020312) and the AMPK agonist (AICAR) could reverse the protective effects of SeNPs on IPEC-J2 cells. The PERK inhibitor (GSK2656157) and the AMPK inhibitor (compound C) had a similar effect on IPEC-J2 cells as that of SeNPs. In summary, the protective effects of SeNPs on intestinal barrier dysfunction are closely associated with ERS-related PERK and mitophagy-related AMPK signaling pathway.
[Retracted] Effects of Anesthetics on Proliferation and Apoptosis of Drug‐Resistant Human Colon Cancer Cells
Authors: Tang Chunrong , Fu Shengdan , She Dongsheng , Zhou Juan , Su Weixia , Zeng Tao
Published: August 2022

In recent years, people’s living standards are getting higher and higher, and life pressure is also increasing, and there are also many problems in eating habits. This is also the direct cause of colon cancer. The aim of this paper was to investigate whether anesthetic drugs could positively affect the proliferation and apoptosis of colon cancer cells. In this paper, the significance of anesthetic drugs is proposed, and an artificial neural network algorithm based on artificial intelligence is proposed. It is well known that artificial neural networks play an important role in medicine. The experimental results of this paper show that the incidence of colon cancer in 2020 will be in the range of 5%‐35%, and the incidence of colon cancer in 2021 will be in the range of 7%‐30%. While colon cancer rates in 2021 do not appear to be as high as colon cancer rates in 2020, they are generally much higher than colon cancer rates in 2020. It can be seen that as the population ages, the number of colon cancer patients is increasing due to the lack of emphasis on health. This also means that the incidence of colon cancer is getting higher and higher, and traditional drug chemotherapy has been unable to play a good role in inhibiting the proliferation of colon cancer cells. Therefore, this paper investigated the effects of anesthetic drugs on the proliferation and apoptosis of human colon cancer cells.
[Retracted] Histological Classification and Invasion Prediction of Thymoma by Machine Learning‐Based Computed Tomography Imaging
Authors: Wang Danfeng , Zhang Yiwei , Li Bingli , Zhuang Qiaowei , Zhang Xiaoqin , Lin Daiying
Published: August 2022

Purpose. The values of machine learning‐based computed tomography (CT) imaging in histological classification and invasion prediction of thymoma were investigated. Methods. 181 patients diagnosed with thymoma by surgery or biopsy in Shantou Central Hospital between February 2017 and March 2022 were selected. According to the concept of simplified histological classification and the latest histological classification by the WHO, thymoma was divided into two groups, including low‐risk (types A, AB, B1, and metaplastic type) and high‐risk groups (types B2 and B3). CT images were reconstructed by filtering back projection (FBP) algorithm. CT image features were collected for statistical analysis. Results. The main symptoms of patients diagnosed with thymoma included respiratory tract infection, chest distress and shortness of breath, and chest pain. 35.91% of them suffered from complicated myasthenia gravis. Tumor size and position in low‐risk and high‐risk groups showed no statistical significance (P > 0.05). Tumor morphology and boundary between the two groups suggested statistical difference (P < 0.05). Whether tumor invaded adjacent tissues was apparently correlated with simplified histological classification (P < 0.01). The sensitivity and specificity of CT images for the invasion of mediastinal pleura or pericardium were around 90% and negative predictive values both reached above 95%. Those of the CT images for lung invasion were over 80%. The negative and positive predictive values were 93.54% and 63.82%, respectively. Those of the CT images for blood vessel invasion were 67.32% and 97.93%. The negative and positive predictive values were 98.21% and 83%, respectively. Conclusion. The machine learning‐based CT image had significant values in the prediction of different histological classification and even invasion level.
Distributed Soccer Training Smart Sensors for Multitarget Localization and Tracking
Authors: Jiang Jian , Qiu Zhiqun
Published: August 2022

This paper presents an in-depth study and analysis of the localization and tracking of multiple targets in soccer training using a distributed intelligent sensor approach. An event-triggered mechanism is used to drive the acoustic array sensors in the distributed acoustic array sensor network, which solves the problem of increased communication load caused by frequent communication of microphones and effectively reduces the communication load between microphones as well as the energy consumption of the acoustic array sensor network. By designing a suitable state estimation equation for the acoustic source target and fully utilizing the measurement and state estimation information of its nodes as well as the state estimation information of neighboring nodes, the next moment state of the acoustic source target can be accurately predicted. A correlation filtering tracking algorithm based on multiscale spatial co-localization is proposed. In the proposed algorithm, the tracker contains a total of several subfilters with different sampling ranges. Then, this paper also proposes a collaborative discrimination method to judge the spatial response of the target image samples of each filter and jointly localize the target online. Based on this, this paper further explores the potential of correlation filter tracking algorithms in complex environments and proposes a robust correlation filter tracking algorithm that fuses multiscale spatial views. The cross-view geometric similarity measure based on multiframe pose information is proposed, and the matching effect is better than that based on single-frame cross-view geometric similarity; to solve the problem of player appearance similarity interference, a graph model-based cross-view appearance similarity measure learning method is further proposed, with players in each view as nodes, player appearance depth features as node attributes, and connections between cross-view players as edges to construct a cross-view player graph. The similarity obtained by the graph convolutional neural network training is better than the appearance similarity calculated based on simple cosine distance.
[Retracted] Public View of Public Health Emergencies Based on Artificial Intelligence Data
Authors: Zhang Shitao , Chu-ke Chun , Kim Hyunjoo , Jing Changqiang
Published: August 2022

In the current environment where the network and the real society are intertwined, the network public view of public emergencies has involved in reality and altered the ecology of communal public views in China. A new online court of influence has been created, and it affected the trend of events. As the main type of public emergencies, public health emergencies are directly related to people’s health and life insurance. Therefore, the public often pays special attention. At present, correct media guidance plays an irreplaceable and important role in calming people’s hearts and stabilizing social order. If news and public view are left unchecked, it is likely to cause panic among the people. However, in reality, public view research has always been a research object that is difficult to intelligentize and quantify. Based on such a realistic background, the article conducts a research on public view of public health emergencies based on artificial intelligence data analysis. This study designs an expert system for network public view and optimizes the algorithm for the key problem: SFC deployment. Finally, the system was put into real news and public opinion research on new coronavirus epidemic prevention, and experimental tests were carried out. The experimental results have shown that in the new coronavirus incident, the nuclear leakage incident, and the epidemic prevention policy, the data obtained by the public through the Internet are 50%, 68.06%, and 64.35%, respectively. For the system function in this study, both ICSO and IPSO are far better than the optimization results of CSO and PSO. For most of the test functions, IPSO is better than ICSO’s optimization results, which better fulfills the needs of the research content. This study will make an in‐depth analysis of the evolution process of online public opinion on public emergencies from the macro‐, meso‐, and micro‐perspectives, in order to analyze the dissemination methods and internal evolution mechanism of various public emergencies of online public opinion, which provides countermeasures and suggestions for the government to guide and manage network public opinion.
Study on Stress-Strain Characteristics of Pipeline-Soil Interaction under Ground Collapse Condition
Authors: Liu Xiaohui , Sun Zhizhong , Zhu Jianping , Fang Yingchao , He Yanglian , Pan Yuchen
Published: August 2022

Ground collapse is one of the main geological disasters affecting the safe operation of oil and gas pipelines. Studying the stress-strain characteristics of pipe-soil interaction under ground collapse has an important guiding role for the prevention of ground collapse and the safety protection of pipelines. The current results are mostly concentrated in a single theory or the stress of the pipeline itself, which cannot fully consider the pipe-soil interaction. In this paper, ABAQUS is used to establish the finite element geometric model. Considering the pipeline and the surrounding geological environment conditions, the study is carried out from five aspects: the length of the collapse area, the thickness of the cover layer, the buried depth of the pipeline, the diameter of the pipeline, and the thickness of the pipeline. The displacement of the pipeline soil, the deformation of the pipeline, and the characteristics of the pipeline stress are analyzed, and the variation law is determined through the development trend of the pipeline stress and strain. At the same time, by fitting and analyzing the relationship between the span of different subsidence areas, the thickness of the cover layer, the buried depth of the pipeline, the diameter of the pipeline, the thickness of the pipeline, and the maximum deformation of the pipeline, the reference value of the maximum subsidence displacement of the pipeline under the action of ground collapse is proposed. The work has practical application value for pipeline monitoring, early warning, and disaster management.
tRNA-Derived Fragment tRF-5009A Regulates Autophagy and Degeneration of Cartilage in Osteoarthritis via Targeting mTOR
Authors: Deng Zengfa , Long Dianbo , Liu Hailong , Xu Yiyang , Xin Ruobing , Liao Hongyi , Li Zhiwen , Li Ruiyun , Mao Guping , Zhang Ziji , Kang Yan
Published: August 2022

tRNA-derived fragments (tRFs) have been reported to have critical regulatory roles in osteoarthritis (OA). Recent studies have suggested that autophagy promotes the homeostasis of the extracellular matrix of chondrocytes in OA. However, the role of tRFs in posttranscriptional gene regulation during autophagy in OA is unknown. Therefore, we explored the role of tRF-5009A in the posttranscriptional gene regulation of autophagy and cartilage degeneration in OA. Using RNA sequencing, we identified tRF-5009A, the tRNAValCAC-derived fragment, in OA tissues and explored its expression by quantitative reverse transcription PCR and fluorescence in situ hybridization. We further investigated the relationship between the expression of tRF-5009A and clinical factors in OA. Chondrocytes were transfected with a tRF-5009A inhibitor or mimic to determine their functions, including in relation to autophagy and the cartilage phenotype. A rescue experiment and dual-luciferase reporter assay were conducted to determine whether the 3

′

-untranslated region (UTR) of mTOR contains a tRF-5009A-binding site. tRF-5009A was downregulated in the cartilage of OA knees, especially in damaged areas. mTOR was highly expressed in damaged cartilage and negatively correlated with the expression of tRF-5009A; transfection with a tRF-5009A inhibitor promoted the expression of mTOR and suppressed autophagy, whereas transfection with a tRF-5009A mimic had the opposite effect. A dual-luciferase reporter assay showed that tRF-5009A silenced the expression of mTOR by binding to its 3

′

-UTR. Thus, tRF-5009A regulates autophagy and cartilage degeneration in OA by targeting mTOR. In summary, these findings provide an additional tool for the clinical diagnosis and novel targeted therapy of OA.
Application of Intelligent Image Matching and Visual Communication in Brand Design
Authors: Liu Ming , Zhong Wenyan
Published: August 2022

In this paper, from the perspective of improving the visual communication of brand design, image texture intelligent matching processing is needed, proposing a brand design texture intelligent matching method based on visual communication, constructing a brand design texture intelligent information acquisition model under visual communication, using automatic image imaging technology for texture imaging and feature segmentation of brand design, and extracting typical brand design and ethnic design language of texture histogram, texture segmentation, and automatic matching under visual communication according to histogram distribution, brand design texture information enhancement and optimization detection by regularized feature fusion method, extraction of edge contour feature points of brand design, and texture matching with the extracted edge contour feature points of decorative patterns as input statistics. The adaptive performance of texture matching for a brand design using this method is better, and the texture discrimination ability is stronger, which improves the application research of better reflecting brand design in modern visual communication design and promotes the innovative combination of traditional cultural elements and modern design.
Big Data Storage Index Mechanism Based on Spatiotemporal Information Cloud Platform
Authors: Xu Junmei , Chen Bin , Sun Liying
Published: August 2022

In order to study the storage and management mechanism of raster data and vector data for different purposes in data services, a research method of big data storage and indexing mechanism based on spatiotemporal information cloud platform is proposed. This paper discusses the application of big data storage index in virtualization platform, cloud management software, and storage management, so that Hadoop cluster can use the dynamic expansion ability of cloud platform to obtain better expansion ability. High performance statistical applications for geographical conditions are constructed. A high performance geostatistical analysis system Hadoop-Geostatistics is designed and implemented. A variety of spatial statistics index calculation, flow, and MapReduce algorithm was realized. The experimental results show that in the cluster environment, the time consumption is basically the same as that of the single index calculation, while in the single computer environment, when the comprehensive index is calculated in parallel for 10,000 statistical objects, the system performance drops rapidly and reaches an early inflection point. In the comprehensive statistical concurrent calculation, when the time consumption reaches 5 × 10^7, the amount of calculation data is as high as 7000, which increases linearly. The experimental data show that the designed spatiotemporal information cloud platform model can store spatial big data, and the storage method is very accurate. By establishing a spatiotemporal information cloud platform, cloud computing technology can provide higher spatial information services.
Evaluation of Therapeutic Efficacy of Copper Nanoparticles in Staphylococcus aureus‐Induced Rat Mastitis Model
Authors: Taifa Syed , Muhee Amatul , Bhat Riyaz A. , Nabi Showkat UI , Roy Arpita , Rather Gulzar Ahmed , Khan Azmat Alam , Bashir Showkeen Muzamil , Patwekar Mohsina , Wahab Shadma , Alghamdi Saad , Dablool Anas S. , Kabrah Ahmed , Hani Umme , Bannunah Azzah M. , Patwekar Faheem , Mallick Jewel
Published: August 2022

The current study was devised to develop alternative, nonantibiotic, and economically viable treatments for bovine mastitis. The concentration of 6.25 μg/mL (25 nm) CuNPs was selected as intramammary (IM) treatment in S. aureus‐induced mastitis in rats as this concentration showed a significant zone of inhibition through the in vitro sensitivity test and minimal cell toxicity on fibroblast cell lines. After, this in vivo study was conducted, and rats were divided into four groups of 6 rats each: group I (healthy control/deionized water), group II (disease control), group III (CuNPs), and group IV (gentamicin). Injection of gentamicin IM for 5 days was selected on the basis of an antibiotic sensitivity test. The therapeutic efficacy of CuNPs was assessed on the basis of clinical signs, mammary gland architecture, bacterial load, oxidative stress parameters, and histopathology of mammary glands. The clinical signs of mastitis in group III ameliorated within 3 days of treatment while in group IV clinical signs ameliorated within 4 days of initiation of treatment. On the 5th day after randomization, bacterial load, mammary gland weights, TOS (Total Oxidant Status), and OSI (oxidative stress index) were significantly lower in the CuNPs group compared to the disease control group and commercial antibiotic group. Similarly, TAS of group III was significantly higher compared to that of groups II and IV indicating that CuNPs have better ameliorative efficacy in mastitis. Treatment with IM, CuNPs @ 6.25 μg/mL showed early recovery, reduced bacterial loads, and amelioration of oxidative stress indices henceforth resulting in marked amelioration in histopathological changes compared to rats in group IV. From this study, it may be concluded that CuNPs may provide a potential alternative therapeutic regimen for the treatment of bovine mastitis.
Intimate Partner Violence and Its Predictors among Pregnant Women in Eastern Ethiopia: Generalized Structural Equation Modeling
Authors: Misgana Tadesse , Weldesenbet Adisu Birhanu , Tamiru Dawit , Tariku Mandaras , Tesfaye Dejene , Alemu Daniel , Gebremichael Berhe , Dheresa Merga
Published: August 2022

Introduction. Intimate partner violence (IPV) has a negative impact on women’s physical, mental, sexual, and reproductive health. Identifying the determinant factors of IPV among pregnant women is of paramount importance to overcome its negative consequences thereby increasing the performance of women in all activities. Thus, this study applied a generalized structural equation model (GSEM) to determine the prevalence of intimate partner violence among pregnant women and its predictors in Eastern Ethiopia. Methods. A community based cross-sectional study was conducted in Kersa Health and Demographic Surveillance System (KHDSS), Eastern Ethiopia. Data were collected form a sample of 1051 pregnant women using structured questionnaires. Descript findings were presented in percentage with 95% confidence interval. The generalized structural equation model was used to determine factors associated with each domain of IPV (physical, emotional, and social violence). Adjusted odds ratio (AOR) with a 95% CI were used to declare significant factors associated with intimate partner violence. Results. The overall prevalence of IPV in the Eastern Ethiopia was 48.57% (95% CI: 45.45, 51.69). The highest intimate partner violence was observed in the sexual domain of IPV (31.6%, 95% CI: (28.8, 34.58)). In GSEM, being a farmer (

AOR
=
0.42

, 95% CI: 0.19, 0.91) was significantly associated with psychological domain of IPV. Age (

AOR
=
0.97

, 95% CI: 0.95, 0.99) and educational status (neither read nor write) (

AOR
=
2.50

, 95% CI: 1.61, 3.89) were significantly associated with physical domain of IPV. Being in medium (

AOR
=
0.64

, 95% CI: 0.46, 0.90) and rich (

AOR
=
0.53

, 95% CI: 0.36, 0.78), wealth quintiles were significantly associated with sexual domain of IPV, whereas husband controlling behavior was significantly associated with all domains of IPV. Conclusions. The magnitude of IPV among pregnant women was relatively high in Eastern Ethiopia. This finding pin a light to pay special consideration to pregnant women at each point of service delivery to alleviate consequence of IPV. Being a farmer, older ages and being in higher wealth quintiles were protective factor, whereas being uneducated increase the risk of IPV. Improving socioeconomic status and promoting legal rights of women is needed to alleviate the problem, and younger women require special attention.
Intertwine Connection-Based Routing Path Selection for Data Transmission in Mobile Cellular Networks and Wireless Sensor Networks
Authors: Vijay  , Siddiqui Shams Tabrez , Ritu  , Kumar Relangi Anil , Kumar Avinash , Umamaheswararao S. , Dudiki Narahari , Reddy Y. Venkateswara , Dekeba Kenenisa
Published: August 2022

In a network setting, a sensor node's round-trip delay time over hostile nodes compromises the node's ability to transmit data from the sender node to the destination node. Minimum distance path discovery causes the path failure, since aggressive nodes are available. Node connectivity is poor which should cause the packet loss; it does not control more energy consumption, since packet broadcasting is repeated for many times using that path. So, the proposed intertwine connection-based routing path selection (ICBRPS) technique allows only energy efficient routing path, path connectivity is important, and routing path is damaged because of the presence of aggressive nodes. It hacks the information from sensor and operates unpredictable manner. The objective of this presented ICBRPS scheme is to improve the routing path in efficient manner. If any damages occur during the transmission of data, then the alternate best node connectivity path is created by energetic route discovery method. The performance metrics of parameters are delay, network overhead, energy consumption, packet loss, packet delivery ratio, and connectivity ratio. It enhances the connectivity rate and reduces the energy consumption.
Integrated Development of Smart City Tourism and Cultural and Creative Industries Based on Internet of Things
Authors: Liu Shiyan
Published: August 2022

In order to solve the problem of asymmetric development of cultural and creative industries in smart city tourism, this paper proposes an analysis method based on the IPA model. Based on the analysis of the current situation of the tourism cultural and creative projects in the traditional block, this method combines the RMP analysis theory and the tourist satisfaction theory to study the local cultural elements and the satisfaction of tourism cultural and creative projects with the IPA model. The results are as follows: sightseeing (42.5%) is the highest motivation of tourists, followed by cultural and creative experience (16.2%), of which 84.8% are self-help tourists, and only 2.3% choose to join the group. Life custom is a significant factor influencing the satisfaction of patients who think it is very important but are actually dissatisfied. Smart tourism and creative tourism projects are considered important by the respondents, but there is a large difference between expectations and perceptions. These are the projects that managers need to focus on to correct at present. It proves that the activation of tourism cultural and creative projects should follow the market-oriented principle, the principle of reflecting characteristics, the principle of cultural guidance, the principle of effectiveness, and the principle of sustainable development in order to achieve the ultimate success.
Numerical Study on the Relationship between the Dominant Frequency of Blasting Vibration and the Development of Plastic Zone in Cylindrical Charge
Authors: Liu Da , Zhao Xiaohua , Gao Jianglin , Xue Binghan , Wu Xiaobin , Hu Songtao , Chen Fang
Published: August 2022

Blasting vibration is a widely studied harmful effect of rock blasting excavations. Many factors affect its dominant frequency, which makes analyzing, evaluating, and predicting it difficult. This study explored the factors influencing the dominant frequency of blasting vibrations in the case of a spherical charge. Based on symmetry, a theoretical analysis in terms of a spherical explosion source is generally sufficient to describe a cavity excited by a spherical explosion charge. The elastic cavity radius and the dominant frequency of vibration induced by the spherical blasting source are closely related. However, there is a lack of relevant research on cylindrical charges. Therefore, a calculation model for a single-hole cylindrical charge was established. There is a relationship between the corresponding dominant frequency and the range of the plastic zone. The results indicate that the dominant frequency of the blasting vibration for both cylindrical and spherical charges is closely related to the range of the plastic zone formed by the rock blasting. As the elastic cavity radius increases, both the zero-crossing and the dominant Fourier frequencies decrease, and the amplitude spectrum shifts to lower frequencies. However, increasing the cylindrical charge diameter causes more changes in the plastic zone in the direction perpendicular to the cylindrical explosive axis. Moreover, increasing the charge length causes more changes in the plastic zone along this axis. It is therefore difficult to identify a unique dimensional parameter that characterizes the range of the plastic zone formed by the blasting. Because the plastic zone around a cylindrical charge is less regular than around a spherical charge, the charge weight

Q

is a more favorable parameter than the elastic cavity radius

a

when used as the main influencing factor and in an attenuation analysis for the dominant frequency of cylindrical charge blasting.
Online Course Recommendation Using Deep Convolutional Neural Network with Negative Sequence Mining
Authors: Gao Ming , Luo Yonghan , Hu Xiaonan
Published: August 2022

Massive Open Online Course (MOOC) has been criticized for low completion rates, and one of the major reasons is that it fails to offer personalized course recommendations for different users with different demands. To solve this problem, this paper proposes a personalized course recommendation model based on convolutional neural network combined with negative sequence pattern mining. The model first models the course-learning sequence as a negative sequence pattern according to the user’s course registration, degree of completion, and final grades, in which, the negative term means that students should not choose and misoperate the principle of courses. Then, it employs a convolutional neural network structure to extract the internal features of negative sequence patterns for representation learning. Finally, through the convolutional sequence-embedding model, each user is recommended with a course list that includes the user’s maximized needs in recent temporal terms and the courses that are easy to be misselected. Experiment results show that the recommended model achieves higher recommendation performance with lower course dropout rate compared to baselines, which provides a new insight for both online and offline course recommendation.
Creativity of Nanofiber Materials and Application in the Expressive Power of Manual Tie-Dyeing Process
Authors: Wen Jing , Lu Xueqing , Jiang Mai , Shao Xiaohua
Published: August 2022

Traditional printing and tie-dyeing are an important part of Chinese handicrafts. It consists of three main techniques: batik, tie-dye, and multi-layer dyeing. Among the traditional printing and dyeing techniques, tie-dyeing creates an ever-changing visual artistic effect due to the diversity of its production methods. In modern society with the unprecedented development of technology and information, people’s life rhythm has accelerated, and the opposite “slow fashion” has become popular. More and more people are focusing more on the traditional craft of tie-dyeing. In contemporary fiber art, raw materials have become the soul and foundation of fiber art. This is also the difference between modern fiber art and traditional textile art. Entering the new era, the demand for textiles by people of all countries is also increasing, new functional requirements are put forward for textiles, and functional textiles emerge as the times require. The creative display of nanofibers is a comprehensive grasp of the properties of the fibrous material. It is the creativity and expression generated under the premise of understanding the type, shape, craft, and expression of fiber. It fully reflects the characteristics of the material itself, and it is also the designer’s ideological expression of the texture and shape of the material. It is then materialized into a certain connotation by appropriate technical means. In this paper, manual tie-dyeing is applied to nanofiber materials, making full use of the advantages of modern nanomaterials to promote the development of fabric tie-dyeing technology. In the performance test of the transmittance of nanomaterials to ultraviolet rays, it can be found that the transmittance of nanomaterials through the tie-dyeing process is lower for optical fibers with shorter wavelengths. When the wavelength of ultraviolet light is 313 nm, the transmittance of ZnO to ultraviolet light is 0. When the ultraviolet wavelength is 435 nm, the transmittance of ZnO to ultraviolet light is 45%.
Assessment of Households’ Willingness to Join and Pay for Improving Waste Management Practices in Gedeo Zone, Southern Ethiopia
Authors: Kaso Abdene Weya , Hareru Habtamu Endashaw , Ashuro Zemachu , Soboksa Negasa Eshete
Published: August 2022

Background. Waste management has become a serious challenge in urban areas of developing countries. However, managing municipal solid waste generated is the most costly urban service and needs community engagement in management of municipal solid wastes. Therefore, this study determined willingness to join and pay for improving solid waste management services and associated factors among households of Gedeo zone, Southern Ethiopia. Method. We performed a community‐based cross‐sectional study design to assess willingness to join and pay for improved solid waste management and its predictors among residents in Gedeo zone, Southern Ethiopia. Multivariate logistic regression analysis was computed to identify the factors associated with willingness to join and pay for improved solid waste management services. An adjusted odds ratio (AOR) with a 95% confidence interval (CI) was used to report an association, and a p < 0.05 was used to declare a statistically significant association. Result. Of 552 study participants, 91.5% (95% CI: 89.2, 93.8) were willing to join and 86.3% (95% CI: 83.3, 89.4) of them were willing to pay for improving solid waste management services. Having a large family size, higher educational status, positive attitude, and good knowledge of waste management services, access to waste management services, and amount of waste generated per week were positively associated with willingness to support improved solid waste management services. In addition, we found that respondents with high educational status, monthly income, who had good knowledge of waste management, access to waste management services, and the amount of waste generated per week were significant predictors of willingness to pay for improved solid waste management. Conclusion. This study found that a significant number of the respondents were willing to support and pay for improved solid waste management services. A higher probability of willingness to support and pay for solid waste management services among residents who had access to waste management services and good knowledge of solid waste management was observed. Therefore, wide‐range awareness creation through mini media should be used to address poor knowledge. In addition, establishing more temporary waste collection sites in every corner of cities is needed to encourage households to support and pay for improved solid waste management services.
Does Therapeutic Zinc Level of Supplementation for Diminutions of Acute Diarrheal Morbidity Varied in Public and Private Health Institutions in Ethiopia, Data from EDHS 2016?
Authors: Kebede Fassikaw , Markos Merkineh
Published: August 2022

Background. Supplementation of zinc is a therapeutic medication for under-five children diminution incidence, severity, duration, and intensity of acute diarrhea morbidity. Nevertheless, levels of therapeutic zinc supplementation varied across public and private health institutions in Ethiopia. Thus, this study was aimed at estimating the levels of therapeutic zinc supplementation and factors associated for intent to be utilized among caregivers with their dyads, data from Ethiopia Demographic and Health Survey (EDHS 2016). Methods. The data used were from a secondary analysis of the Ethiopia Demographic and Health Survey in 2016 (EDHS). Overall, 1090 under-five children with acute diarrheal cases of two weeks before the EDHS 2016 were included. After cleaning, editing, and coding variables, the result was presented with frequency, tables, and graphs. Bivariable and multivariable logistic regression was conducted to identify and determine factors associated after zinc is prescribed for utilizations by caregivers. Result. The mean (±SD) age of participant children was found to be 36.4(±7.07) month. The overall levels of therapeutic zinc supplementation were 38.7% (95% CI: 35.8, 41.6) in public (29.08%) and private 138 (12.66%), respectively. The prescribed therapeutic zinc was influenced for utilization through maternal educational status (

AOR
=
2.55

; 95% CI: 1.95, 3.47;

P
=
0.001

), availability of health insurance (

AOR
=
10.7

; 95% CI: 7.2, 16;

P
=
0.001

), media exposure status (

AOR
=
2.1

; 95% CI: 1.7, 3.6;

P
=
0.001

). Conclusion. More than twofold time therapeutic zinc was prescribed in public than in private health institutions. Health care workers should be encouraged both in public and private health institutions for zinc prescription.
Escherichia coli–Specific CXCL13-Producing TFH Are Associated with Clinical Efficacy of Neoadjuvant PD-1 Blockade against Muscle-Invasive Bladder Cancer
Authors: Goubet Anne-Gaëlle , Lordello Leonardo , Alves Costa Silva Carolina , Peguillet Isabelle , Gazzano Marianne , Mbogning-Fonkou Maxime Descartes , Thelemaque Cassandra , Lebacle Cédric , Thibault Constance , Audenet François , Pignot Géraldine , Gravis Gwenaelle , Helissey Carole , Campedel Luca , Roupret Morgan , Xylinas Evanguelos , Ouzaid Idir , Dubuisson Agathe , Mazzenga Marine , Flament Caroline , Ly Pierre , Marty Virginie , Signolle Nicolas , Sauvat Allan , Sbarrato Thomas , Filahi Mounia , Davin Caroline , Haddad Gabriel , Bou Khalil Jacques , Bleriot Camille , Danlos François-Xavier , Dunsmore Garett , Mulder Kevin , Silvin Aymeric , Raoult Thibault , Archambaud Baptiste , Belhechmi Shaima , Gomperts Boneca Ivo , Cayet Nadège , Moya-Nilges Maryse , Mallet Adeline , Daillere Romain , Rouleau Etienne , Radulescu Camelia , Allory Yves , Fieschi Jacques , Rouanne Mathieu , Ginhoux Florent , Le Teuff Gwénaël , Derosa Lisa , Marabelle Aurélien , Van Dorp Jeroen , Van Dijk Nick , Van Der Heijden Michiel S. , Besse Benjamin , Andre Fabrice , Merad Miriam , Kroemer Guido , Scoazec Jean-Yves , Zitvogel Laurence , Loriot Yohann
Published: August 2022

Biomarkers guiding the neoadjuvant use of immune-checkpoint blockers (ICB) are needed for patients with localized muscle-invasive bladder cancers (MIBC). Profiling tumor and blood samples, we found that follicular helper CD4+ T cells (TFH) are among the best therapeutic targets of pembrolizumab correlating with progression-free survival. TFH were associated with tumoral CD8 and PD-L1 expression at baseline and the induction of tertiary lymphoid structures after pembrolizumab. Blood central memory TFH accumulated in tumors where they produce CXCL13, a chemokine found in the plasma of responders only. IgG4+CD38+ TFH residing in bladder tissues correlated with clinical benefit. Finally, TFH and IgG directed against urothelium-invasive Escherichia coli dictated clinical responses to pembrolizumab in three independent cohorts. The links between tumor infection and success of ICB immunomodulation should be prospectively assessed at a larger scale.

Significance:

In patients with bladder cancer treated with neoadjuvant pembrolizumab, E. coli–specific CXCL13 producing TFH and IgG constitute biomarkers that predict clinical benefit. Beyond its role as a biomarker, such immune responses against E. coli might be harnessed for future therapeutic strategies.

This article is highlighted in the In This Issue feature, p. 2221
Belly Fat Weakens Immune Fitness
Authors: Conejo-Garcia Jose R. , Curiel Tyler J.
Published: August 2022

Much work has been done to reduce cancer immunosuppression through inhibiting soluble proteins, surface molecules, and suppressive cells. This article shows an important role for the lipid lysophosphatidic acid, whose suppression shows promise as a novel cancer immunotherapeutic, demonstrated in ovarian cancer.

See related article by Chae et al., 1904 (5).
UltraPulse Carbon Dioxide Laser Plus Methyl Aminolevulinate-Photodynamic Therapy for the Treatment of Penile Cancer
Authors: Mercuri Santo Raffaele , Paolino Giovanni , Brianti Pina , Di Nicola Matteo Riccardo , Martini Alberto , Necchi Andrea , Montorsi Francesco
Published: August 2022

The treatment of early-stage penile carcinoma is usually represented by wide excision or partial penectomy with or without inguinal lymph node dissection. However, laser ablation of the tumor may have a prominent role as an organ-sparing approach. In this regard, the combination of UltraPulse CO2 laser and photodynamic therapy (PDT) may be a valid option, especially when surgery is not feasible or refused. UltraPulse CO2 laser allows for the formation of gentle cutaneous abrasion that destroys the malignant tissue and, at the same time, improving the uptake of methyl aminolevulinate and amplifying the photochemical reaction of PDT in the tumor and surrounding tissue.
Skin Treatment with Detergent Induces Dermatitis with H1-Antihistamine-Refractory Itch and Upregulates IL-4 and Th17/Th22 Cytokine Gene Expression in C57BL/6 Mice
Authors: Masutani Yurie , Takai Toshiro , Kamijo Seiji , Kimitsu Toru , Yoshimura Tomoko , Ichikawa Saori , Shimizu Saya , Ogawa Takasuke , Takada Keiko , Tominaga Mitsutoshi , Suto Hajime , Takamori Kenji , Ogawa Hideoki , Okumura Ko , Ikeda Shigaku
Published: August 2022

Introduction: Repeated skin contact to detergents causes chronic irritant contact dermatitis (ICD) associated with itch sensation and eczema. However, the mechanisms of detergent-induced ICD are poorly understood. Here, we established a new murine model of detergent-induced ICD with H1-antihistamine-refractory itch. Methods: Ear skin of wild-type and mast cell-deficient mice on the C57BL/6 genetic background was treated with a detergent, sodium dodecyl/lauryl sulfate (SDS), daily for approximately 2 weeks with or without administration of an H1-antihistamine, fexofenadine. Skin inflammation, barrier dysfunction, and itching were analyzed. Quantitative PCR for earlobe gene expression and flow cytometry analysis for draining lymph node cells were conducted. Results: SDS treatment induced skin inflammation with ear swelling, increased transepidermal water loss, and hind-paw scratching behaviors in the wild-type and mast cell-deficient mice. The peak value of scratching bouts was retained for at least 48 h after the last SDS treatment. H1-antihistamine administration showed no or little reduction in the responses. SDS treatment upregulated gene expression for a Th2 cytokine IL-4 and Th17/Th22 cytokines, IL-17A, IL-17F, and IL-22, and increased cell numbers in draining lymph nodes of CD4+ T, CD8+ T, and γδT cells with enhanced expression of GATA3, RORγt, T-bet, or FOXP3 compared with untreated mice. Conclusions: The present study showed that SDS treatment of ear skin in C57BL/6 mice induces mast cell-independent skin inflammation with H1-antihistamine-refractory itch and suggested a possible Th cytokine- and/or lymphocyte-mediated regulation of the model. The model would be useful for elucidation of mechanisms for inflammation with H1-antihistamine-refractory itch in detergent-induced ICD.
EPOC: Diagnóstico oportuno en el primer nivel de atención
Authors: Thirión-Romero Ireri Isadora
Published: August 2022

Background: The COPD Diagnostic Questionnaire (CDQ) was developed to identify people who would benefit from spirometry testing to confirm Chronic Obstructive Pulmonary Disease (COPD). The aim of this study was to determine the usefulness of a cut-off score of 16.5 on the CDQ in identifying those at increased risk of obstruction, in a mixed population of people ‹at risk› of COPD and those with an ‹existing› COPD diagnosis. Methods: People ‹at risk› of COPD (aged > 40 years, current/ex-smoker) and those with ‹existing› COPD were identified from four general practices and invited to participate. Participants completed the CDQ and those with a CDQ score ≥ 16.5 were categorised as having intermediate to increased likelihood of airflow obstruction. Pre and post-bronchodilator spirometry determined the presence of airway obstruction (FEV1/FVC ratio < 0.7). Sensitivity, specificity and accuracy of the CDQ was determined compared to spirometry as the gold standard. Results: One hundred forty-one participants attended an initial assessment (‹at risk› = 111 (79%), ‹existing› COPD = 30 (21%)). A cut-off score of 16.5 corresponded to a sensitivity of 81%, specificity of 36% and accuracy of 50%, in the entire mixed population. The area under the ROC curve was 0.59 ± 0.50 indicating low diagnostic accuracy of the CDQ. Similar results were found in the ‹existing› COPD group alone. Conclusion: Whilst a cut-off score of 16.5 on the CDQ may result in a large number of false positives, clinicians may still wish to use the CDQ to refine who receives spirometry due to its high sensitivity. Trial registration: ANZCTR, ACTRN12619001127190. Registered 12 August 2019 – Retrospectively registered, http://www.ANZCTR.org.au/ACTRN12619001127190.aspx.
Leukoderma Induced by Rotigotine Patch, a Transdermal Dopamine Agonist
Authors: Talty Ronan , Micevic Goran , Wang Alice , Ko Christine J. , Damsky William
Published: August 2022

Leukoderma, or hypomelanosis of the skin, can occur in response to various chemical and pharmacologic substances ranging from topical medications to optic preparations and systemic medications. In this case report, we present a 78-year-old man with a history of restless leg syndrome (RLS) who had been using rotigotine transdermal patches once daily for 1 year and developed leukoderma on the bilateral anterior shoulders in the area of patch application. Histopathologic examination showed an absence of melanocytes at the dermal-epidermal junction confirmed by Melan A stain. While the patient was not bothered by the depigmentation and elected to continue the rotigotine patch for his RLS, this case highlights leukoderma as a potential side effect of dopamine transdermal patches and offers insight into the potential mechanism of hypopigmentation in response to dopamine agonism.