bluuebunny/crossref_metadata_2025 huggingface dataset:
PROFIL MINAT BELAJAR PERSERTA DIDIK DI KELAS VIII SMP N 1 LEMBANG JAYA
Authors: Kemala Niken , Helma Helma , Kardo Rici
Published: February 2025

This research is motivated by the existence of students who are unprepared for learning, late attendance, permission, truancy, activeness in learning, enthusiasm for learning, attention to learning, and interest in learning. The aim of this research is to describe the learning interest profile of students in class VIII SMP N 1 Lembang Jaya seen from the aspects: 1) Feelings of pleasure, 2) Interest, 3) Attention in Learning, and 4) Involvement. This research was conducted using quantitative descriptive methods. The research population was 96 students selected using total sampling technique. The instrument used is a questionnaire. The number of valid questionnaire statements after the trial was 50 items. The data analysis reveals an average percentage of (60,41%) across all aspects, indicating a high category. The results of research on the profile of students' interest in learning in class VIII SMP N 1 Lembang Jaya are seen from the aspects: 1) Feelings of pleasure are in the medium category 2) Interest is in the high category, 3) Attention in learning is in the high category, 4) Engagement is in the high category. Based on the results of this research, it is recommended for guidance and counseling teachers to provide services such as utilizing group guidance and group counseling services, or classical services that are in accordance with what is needed regarding learning interests, then subject teachers are recommended to use a variety of learning methods, for students who have the criteria can increase interest in learning and for future researchers to create an effective guidance service model.
ANALISIS KOMUNIKASI PENDIDIK TERHADAP SISWA BERKEBUTUHAN KHUSUS DI SEKOLAH LUAR BIASA (SLB) SURAKARTA
Authors: Hapsari Lintang Ayu , Ramadhani Nabila Oktavia , Fauzy Ibrahim , Minsih Minsih
Published: February 2025

This research aims to analyze the communication patterns and characteristics used by educators towards students with special needs at SLB Surakarta. Effective communication between educators and students is essential in the learning process, especially in special education settings, where students have a wide range of different needs and abilities. This research uses a qualitative method with a phenomenological approach, which allows researchers to explore direct and in-depth experiences regarding communication interactions between educators and students. Data collection techniques used include observation, interviews, literature study, and information analysis. The results of the research show that there are several communication patterns used by educators at SLB C1 YSSD Surakarta in interacting with students with special needs, including: (1) Two-way communication patterns that encourage active interaction between teachers and students, (2) Verbal communication patterns that involves the use of simple and easy to understand language, (3) Nonverbal communication patterns which include facial expressions, body movements, and gestures to support the message conveyed, (4) Repeated communication patterns carried out to ensure student understanding, (5) Communication patterns that emphasize each word to attract students' attention and help them stay focused, and (6) Communicate with empathy and openness to build closer relationships and support the learning process. The conclusion of this research shows that educators at SLB Surakarta apply various communication patterns designed to overcome challenges in interacting with students with special needs, by emphasizing the importance of clear, empathetic and open communication to support successful learning
PENGARUH MODEL PEMBELAJARAN CONTEXTUAL TEACHING LEARNING (CTL) DENGAN STRATEGI INKUIRI TERHADAP HASIL BELAJAR SISTEM GERAK MANUSIA
Authors: Nursafiah Nursafiah , Kurniawati Kurniawati , Fajriana Nurul , Rosma Fatemah
Published: February 2025

This study aimst determine the effect of the CTL learning model with inquiry strategies on student learning outcomes at SMPN 4 Kutacane. This research uses experimental methods. The population in this study was class VIII students, totaling 85 students. The sample consisted of 44 students consisting of two classes, namely class VIII-2 with 22 students as the experimental class and class VIII/3 as the control class. Data codellection was carried out through pretest and posttest. Data on improving learning outcomes is in the form of normalized gain (N-Gain). The difference in the average N_Gain of the experimental class and the control class was analyzed using an independent sample t-test. The average value of the experimental class is higher than the control class. The results of the t test show that the t value = 2.68 and the t table value = 2.02 (t count > t table) at a significance level of 0.05 which shows that Ho is rejected and Ha is accepted. That there is an influence of the CTL learning model with inquiry strategies on student learning outcomes in human movement systems material.
PENGARUH MICROTEACHING TERHADAP KECEMASAN CALON GURU DALAM PROSES PEMBELAJARAN DI UNIVERSITAS MUHAMMADIYAH ACEH
Authors: Helmanda Cut Mawar , Nazariah Nazariah , Yani Muhammad , Salsabila Siti
Published: February 2025

This research aims to determine the effect of microteaching on the anxiety of prospective teachers in the learning process at University of Muhammadiyah Aceh. This study employs a mixed-methods approach, encompassing both quantitative and qualitative methods. The population of this research consists of students from the Faculty of Islamic Studies at University of Muhammadiyah Aceh, academic year of 2021, who were taking the microteaching course, with a sample size of 20 students. The data collection techniques used included questionnaires and interviews. The data analysis technique used to answer the research questions were normality, linearity and linear regression tests. The results of the study showed that microteaching learning was very meaningful for prospective teacher students in overcoming and reducing their anxiety levels in preparing to teach in front of the class with a strong correlation level and a determination coefficient of 43.2%. This indicates that the microteaching learning variable's ability to influence the anxiety variable of prospective teacher students is 43.2%. The results of this study indicated that there is an effect of microteaching on the anxiety of prospective teachers in the learning process at University of Muhammadiyah Aceh. Furthemore, the feedback from the lecturer and the students helped the performer to deal with the anxiety for the upcoming teaching performance
EFEKTIVITAS PENGGUNAAN MEDIA BERBASIS WORDWALL DALAM PEMBELAJARAN PENDIDIKAN PANCASILA DI KELAS IV SD NEGERI 32 BANDA ACEH
Authors: Maulidar Maulidar , Mislinawati Mislinawati , Vitoria Linda
Published: February 2025

The phenomenon in the field shows that the learning process is not effective because students often feel bored and do not follow Pancasila education lessons. Wordwall-based media is one type of media that can be used to produce effective learning. The method in this research is a qualitative approach with descriptive research type. The research subjects were 34 class IV students at SD Negeri 32 Banda Aceh. The instruments used include student learning activity observation sheets, test sheets, and questionnaires to measure student responses. The research results showed that: 1) students' learning activities reached 89.2% with the criteria "very good"; 2) the use of this media is effective, with 97% of students declared "complete" based on an average score of 94; 3) students' responses to Wordwall media averaged 30.3 in the "positive" category. Thus, the use of Wordwall-based media is effective in learning Pancasila Education
PENERAPAN MEDIA ARTICULATE STORYLINE 3 SEBAGAI PEMBELAJARAN INTERAKTIF PADA MATERI SISTEM PEREDARAN DARAH
Authors: Amir Daniah , Lubis Silvi Puspa Widya
Published: February 2025

This research aims to develop and examine the feasibility of learning media based on Articulate Storyline 3 for circulatory system material for grade XI students at MAN 1 Pidie Jaya. The media development utilized a modified ADDIE model, encompassing analysis, design, development, implementation, and evaluation phases. This study employed both quantitative and qualitative approaches, involving subject matter experts, media experts, and students as respondents. Validation by subject matter and media experts was conducted to assess media feasibility, while small group trials were performed to determine student responses. The results indicate that the developed learning media has a high validity level, with an average assessment of 86% from subject matter experts and 87.67% from media experts. Student response to the learning media was also highly positive, with an acceptance rate of 89%. The media's strengths include interactive displays, animations that facilitate understanding, and interactive quiz features. However, there are some limitations such as computer device requirements and potential technical constraints. Overall, the developed Articulate Storyline 3 learning media has proven to be valid, practical, and effective for use in learning circulatory system material at the high school level
MODEL PROBLEM BASED LEARNING DALAM PENDIDIKAN AGAMA ISLAM: SUATU STUDI EVALUATIF
Authors: Maghfirah Maghfirah , Walidin Warul , Mahmud Salami
Published: February 2025

Educators should choose a learning model that can generate students’ enthusiasm for learning and develop their potential so that they are able to solve the problems faced in life. Problem Based Learning is one of  learning models that is considered can maximize the students’ potential and guide them to have the ability to solve problems in life. Problem Based Learning (PBL) is based on constructivism and accommodates students' involvement in the learning process and problem solving. To apply PBL in the learning process, there are several principles and procedures that must be understood by educators. To implement PBL in the learning process, educators should follow the procedures or implementation stages. The procedure for implementing PBL is divided into several steps, namely: problem orientation, organizing students to study (in groups), investigation or data collection, developing and presenting work results and finally; evaluation and reflection. This PBL model certainly has advantages and disadvantages, so educators should study all things related to this PBL to maximize results and minimize deficiencies, educators should adhere to the principles and procedures for implementing them in the learning process because PBL is one of the learning models that is capable to answer the needs of students and be relevant to the demands of this century.
PENGARUH PENERAPAN PENDIDIKAN MULTIKULTURAL TERHADAP TINGKAT TOLERANSI BERAGAMA BERBASIS PROYEK PENGUATAN PROFIL PELAJAR PANCASILA (P5)
Authors: Lao Hendrik A.E , Pa Hemi D. Bara , Dami Fredrickson
Published: February 2025

Implementing multicultural education is essential in education, as it fosters respectful attitudes among students and promotes a deep understanding of religious tolerance. This study aims to analyze the extent to which the implementation of multicultural education influences the level of religious tolerance at Payeti Christian Middle School, East Sumba Regency. The research employs a quantitative approach, utilizing data collection techniques such as observation, questionnaires, and documentation, and analyzes the data using descriptive statistics with the SPSS 27 application. The results of the study found that the application of multicultural education increased religious tolerance by 33.2% > 5%, which means that Ho was rejected, and Ha was accepted. Thus, multicultural education significantly impacts the degree of religious tolerance, as demonstrated by the P5 initiative at Payeti Christian Middle School in East Sumba Regency. Therefore, the implementation of multicultural education to increase religious tolerance needs to be carried out sustainably.
PENGEMBANGAN ALAT PERAGA KOTAK SIFAT CAHAYA SEBAGAI MEDIA PEMBELAJARAN IPAS SISWA SD
Authors: Malo Ferdinanda Gole , Dinatha Ngurah Mahendra , Dolo Fransiskus Xaverius , Kua Maria Yuliana
Published: February 2025

This study aims to develop and test the validity and practicality of a light properties box as a learning media for students at UPTD SDI Ngoramawo. This teaching aid is designed to help students understand concepts of light properties, such as light traveling in straight lines, being reflected, refracted, and passing through transparent objects. The research uses a Research and Development (R&D) approach with a 3D development model (Define, Design, and Develop). The study was conducted at UPTD SDI Ngoramawo, Bajawa Subdistrict, Ngada Regency, East Nusa Tenggara Province, involving 5 fourth-grade students and 1 teacher. Data analysis was performed by subject matter experts, design experts, and language experts, all of whom are IPAS teachers. The data used includes quantitative data from expert validation results and responses from students and teachers through questionnaires, as well as qualitative data in the form of suggestions and feedback from the evaluators. The validation results showed a percentage of 90% from the subject matter expert, indicating that the teaching aid is considered highly valid for helping students understand the concepts being taught. This result shows that the teaching aid aligns with the learning objectives and can be easily understood by students. A score of 87% from the design expert reflects the evaluation of the visual and functional aspects of the teaching aid. With this value, the teaching aid is deemed to have a good and effective design in delivering the material, although there may still be small aspects that can be improved. The language expert gave a score of 82%. Teacher responses through the questionnaire reached 90.7%, while student responses reached 88%. The developed light properties box demonstrates high validity and practicality for use in IPAS learning in fourth-grade classrooms. The light properties box developed shows high validity with validation percentages of 90% from the subject matter expert, 87% from the design expert, and 82% from the language expert, indicating that the teaching aid aligns with the learning objectives, has an effective design, and uses clear, easily understandable language. Its practicality is confirmed through positive responses from teachers (90.7%) and students (88%), showing that the teaching aid is easy to use in daily learning and effective in helping students understand the concepts being taught
EVALUASI KEMAMPUAN FISIK ATLET PB PASHA JAYA TAHUN 2023
Authors: Masri Masri , Musran Musran , Mansur Mansur , Karimuddin Karimuddin , Ammar Zahran
Published: February 2025

Evaluation of athletes' physical condition is carried out at PB Pasya Jaya to assess the development of their abilities whether they are up to standard. This research aims to evaluate the physical abilities of PB Pasha Jaya athletes in 2024. The method used is a quantitative descriptive approach. The population of the study consists of PB Pasha Jaya athletes, and the sample was obtained using total sampling technique, involving 14 PB Pasha Jaya athletes as the sample. Data collection was conducted through physical tests, which included: 1) arm muscle power test, 2) leg muscle power test, 3) flexibility test, 4) agility test, and 5) cardiorespiratory endurance test. Data analysis was performed using percentage frequency distribution. The evaluation results show that:1) Arm muscle power has an average of 390.36 (42.86%) in the moderate category, 2) Leg muscle power with an average of 37.79 (92.86%) is in the very poor category, 3) Flexibility with an average of 14.9 (50.00%) falls into the good category, 4) Agility with an average of 12.75 (64.29%) is also in the good category, and 5) Cardio- respiratory endurance with an average of 2.45 (42.86%) is in the moderate category. The conclusion of the study is that flexibility and agility are superior to muscle power and heart-lung endurance, so training is needed to improve these two aspects in order to achieve physical balance
MANAJEMEN SDM DALAM PENDIDIKAN : UPAYA PENGELOLAAN SUMBER DAYA MANUSIA DI SEKOLAH
Authors: Haratua Chandra Sagul , Utami Citra Widuri Nur Fajar , Kloudya Mira , Sari Inta Jukanti , Fitriyani Nunu
Published: February 2025

Human resources (HR) are the most valuable assets in an organization, including in the education sector. Effective Human Resource Management can support the achievement of educational goals, both short and long term goals. Management within the school environment must involve important elements, namely educators and educational staff so that it can be ensured that there are competent, motivated and in line with the vision and mission of the institution. By using a literature review method, this journal aims to explore the concepts and practices of Human Resource Management in the school environment, as well as identifying Human Resource management efforts that can help educational institutions achieve their goals. The discussion will cover key aspects of Human Resources Management such as developing the competence of teaching staff, establishing a conducive work culture, implementing technology in managing human resources, and improving the welfare of Human Resources. It is hoped that this journal can provide insight and recommendations for educational practitioners in managing Human Resources in the school environment strategically.
ANALISIS PERILAKU BULLYING DALAM PERSPEKTIF AL-QUR’AN DAN HADITS
Authors: Hasanah Hasanah , Tamarli Tamarli , Saifuddin Saifuddin , Taqiyah Anisah , Nabila Cut
Published: February 2025

This bullying problem is a serious problem for the general public in general, because acts of violence in this day and age can happen anytime if we look at current technological developments, such as deviant behavior, bad ethics, morals and legal norms from the lightest. So the aim of this study is to analyze bullying behavior from the perspective of the Qur'an and Hadith, as we know that the Qur'an and hadith are the main sources for Muslims. The aim of this study is to look at the contents of the verses of the Qur'an and hadith regarding the explanation of bullying. This research method is a Library research method (library research) with qualitative descriptive-analytical analysis. The research results obtained in the Qur'an are the prohibition of insulting and criticizing others, the obligation to act fairly and reject acts of injustice, the prohibition of arrogance and belittling other people. Meanwhile, in the hadith of the Prophet Muhammad SAW it is explained that’s forbidden to mention other people’s shortcomings, to protect other people’s honor, to guard one’s tounge, andit’s forbidden to criticize other people’s physical appearance.
IDENTIFIKASI KONSEP BIOLOGI YANG DIANGGAP SULIT OLEH SISWA SEKOLAH MENENGAH ATAS: A SYSTEMATIC LITERATURE REVIEW
Authors: Hallaby Syarifah Fadiya , Hamama Syarifah Farissi
Published: February 2025

As a field of natural sciences that studies living things, biology not only plays an important role but also basis for various essential applied fields such as agriculture, medical, biotechnology and environmental science. However, biology is also a subject that is often reported difficult to learn. This study aims to identify biology concepts that are considered difficult by high school students in Indonesia through a literature review in the form of a Systematic Literature Review (SLR). The results of the analysis of the selected articles show that the concepts that are considered difficult are distributed at all grades in high school level. The concepts of viruses, plantae, animalia, invertebrate, cells, animal tissue structure and function, excretory system, movement system, disorders in the circulatory system, immune system, cell division, metabolism, enzymes, growth and development of organism and plant tissue culture are biological concepts that are considered difficult by high school students. The factors that cause certain biological concepts are difficult to learn as well as the efforts to overcome the difficulties in the biology learning process related to these concepts are analyzed in this study
Association between extramarital sexual activity, number of sexual partners, and HIV incidence among productive-age adults at H. Adam Malik general hospital, Medan
Authors: Erwina Bella Putri , Ismah Zata
Published: February 2025

HIV/AIDS remains a critical global health challenge, characterized by significant morbidity and mortality. In 2022, Medan reported 1,543 HIV/AIDS cases, with the majority occurring in individuals aged 15–64 years. This study investigates the associations between extramarital sexual activity, the number of sexual partners, and the incidence of HIV among productive-age adults treated at H. Adam Malik General Hospital, Medan, Indonesia. An analytical observational case-control study was employed with 108 participants (54 cases and 54 controls). The analysis identified significant associations between extramarital sexual activities, the number of sexual partners, and HIV infection risk. These findings highlight the urgent need for strengthened global initiatives such as the "Getting to Zero" campaign, youth empowerment through NGOs, and enhanced public health education. Collaborative efforts involving the healthcare sector and government agencies are critical to improving HIV prevention strategies and reducing transmission rates.
К 30-летию официального визита премьер-министра Государства Изра-иль И. Рабина в Российскую Федерацию (апрель 1994 г.) (по материалам АВП РФ). Часть первая
Authors: Смирнов Виктор Юрьевич
Published: February 2025

Исполнилось 30 лет со дня официального визита премьер-министра Государства Израиль И. Рабина в Российскую Федерацию (24–27 апреля 1994 г.). На фоне драматического развития ситуации на Ближнем Востоке, непрекращающегося вооруженного конфликта между Израилем и палестинским движением ХАМАС годовщина этого события прошла незамеченной как в политическом мире, так и в средствах массовой информации. Между тем тот визит тридцатилетней давности оказался заметной вехой в формировании нового характера политических связей и многопланового сотрудничества между двумя странами. В частности, была сформирована договорно-правовая база российско-израильских отношений, сохраняющая свою актуальность и поныне.

Многие аспекты визита И. Рабина в Россию позволяют с исторической дистанции оценить потенциал, который закладывался в те годы
в интересах достижения прочного арабо-израильского урегулирования и в случае его реализации был способен предотвратить возникновение нынешней катастрофической ситуации на Ближнем Востоке, негативно сказывающейся в том числе и на состоянии современных российско-изра-ильских отношений, при том что руководство Российской Федерации остается приверженным ориентирам, которые были определены в те годы, и последовательно выступает за мирное урегулирование палестино-израильского конфликта и укрепление дружественных двусторонних отношений с Израилем.

В статье использованы доступные материалы Архива внешней политики Российской Федерации по вопросам, относящимся к организации официального визита И. Рабина в Российскую Федерацию, его пребывания в Москве и Санкт-Петербурге, а также содержанию состоявшихся тогда советско-израильских переговоров.
Мировой порядок и его современное состояние
Authors: Гринин Антон
Published: February 2025

Мир-Система в настоящее время находится в системном кризисе, который постоянно углубляется быстро растущим противостоянием. Поэтому политологический дискурс во многом вращается вокруг проблемы мирового порядка и его ожидаемой смены. В настоящей статье будут показаны формирование современного американского мирового порядка и некоторые важные характеристики нынешнего состояния мирового порядка, которые характеризуют его как переходный к новой системе. Сначала будут рассмотрены некоторые теоретические вопросы, связанные с понятием мирового порядка. Далее будет описано, как устанавливался однополярный порядок; затем – в чем и как он ослаб и перестал устраивать мировое сообщество. Наконец, автор объясняет, почему на смену США не придет новый абсолютный лидер, а новый мировой порядок будет порядком без абсолютного лидера.
Освещение и трактовка событий Афганской войны 1979–1989 гг. в советской телевизионной публицистике
Authors: Пак Александр
Published: February 2025

Сегодня россияне, даже интересующиеся историей, практически ничего не знают о войне в Афганистане и о том, что советским гражданам много лет пришлось воевать в этой далекой восточной стране. Популярная советская телевизионная публицистика конца 70-х – 80-х гг. XX в. была одним из источников, дававших информацию о том, что происходило в соседней с нами стране, о тех бурных и трагических событиях, которые позднее, вне всякого сомнения, сумели изменить не только судьбы афганского и советского народов, но и ход развития всемирной истории.

Советские журналисты, работавшие в условиях военной и идеологической цензуры, тем не менее старались максимально объективно, насколько это было возможно, доносить до своих зрителей информацию о том, что происходило в Афганистане. Они не были праздными наблюдателями, смело разъезжали по стране, бывали в самых отдаленных уголках, встречаясь как с представителями законной афганской власти, так и с лидерами моджахедов. Некоторые из них погибли во время исполнения своего служебного долга. К сожалению, многие из их полевых заметок и дневников в то время не могли войти в официальные телерепортажи и фильмы из Афганистана. Многие темы Афганской войны долгое время находились под негласным запретом и не могли быть обнародованы. И лишь после распада СССР и крушения коммунистической идеологии многие факты этой войны были оглашены в публичном поле.
Духовная культура Запада и Востока сквозь призму концепции нигилизма представителя Киотской школы Ниситани Кэйдзи
Authors: Скворцова Елена
Published: February 2025

В статье представлен краткий анализ основных моментов философской концепции представителя Киотской школы Ниситани Кэйдзи (1900–1990), одного из учеников самого известного мыслителя Японии Нисиды Китаро. Главный труд жизни Ниситани «Что такое религия?» посвящен проблемам нигилизма. Интерес к этому течению общественной мысли возник у японского ученого под влиянием в первую очередь идеологии Ф. Ницше (в лице которого нигилизм обрел самосознание), а также мировоззренческих идей Ф. М. Достоевского. Большое место в работах Ниситани уделено также творчеству главного нигилиста ХХ в., мыслителя-экзистенциалиста Ж.-П. Сартра. Можно констатировать двухвекторность мировоззренческих установок Киотской школы: с одной стороны, опора на буддийскую и даосскую традицию метафизики, а с другой – использование понятийного аппарата западной эпистемологии. Отсюда синкретизм в стремлении создать аутентичную национальную японскую философию. Ниситани Кэйдзи посвятил свое творчество развитию эстетического и религиозного направления философии как наиболее полно выражающих мировоззренческие особенности японской духовной культуры. При этом он отмечает тот факт, что нигилизм является духовной болезнью не только западной части человечества, но и японского общества.
Анализ повести Лу Цыюня «Жизнеописание Юаньюань»
Authors: Писцов Константин
Published: February 2025

Статья посвящена анализу повести Лу Цыюня (вторая половина XVII – начало XVIII в.) «Жизнеописание Юаньюань». В повести рассказано о жизни Чэнь Юаньюань (1624–1681) – любимой второстепенной супруги полководца У Саньгуя (1612–1678). В статье охарактеризованы прототипы главных героев, рассмотрены художественные особенности произведения. Выдвигается предположение, что интерес Лу Цыюня к исторической роли Юаньюань мог быть обусловлен актуальностью вопроса о женском равноправии в китайском обществе XVII в. В приложении приведен перевод произведения.
Simulation of technological modes for production of silicone molds based on 3D master-models
Authors:   Moscow Automobile and Road Construction State Technical University (MADI), Dvoryankin A.O. , Baurova N. I. ,   Moscow Automobile and Road Construction State Technical University (MADI)
Published: February 2025

It is shown that the technology that allows combining the casting technology and 3D-printing is the FDM 3D-printing technology, since it allows the use of silicone molds, which in turn make it possible to apply one printed master-model to manufacture from 30 to 40 molds while observing the necessary 3D-printing parameters. A program has been developed to calculate the technological modes of manufacturing silicone molds, taking into account the individual parameters of the compounds used, the type of equipment for dosing the compound, as well as 3D master-models on the basis of which silicone molds are made. Recommendations on the use of 3D-printing methods for the production of injection molds are presented.
Diagnosis and treatment of somatoform disorder with gastroenterological symptoms
Authors: Sarsenbaeva A. S. , Malinina E. V. , Mityushkin A. E. , Chinarev V. A. , Mikhailina V. C. , Pokidusheva A. V.
Published: February 2025

Somatic symptoms, under the guise of which mental disorders can be hidden, are a problem for patients, psychiatrists and doctors of other specialties who are faced with this in the first place. Anxiety for one’s health and subjectively experienced bodily sensations force the patient to repeatedly seek medical help, which can aggravate maladjustment and cause significant damage to resources, causing additional stress, closing a vicious circle. Purpose of the study: to analyze the clinical manifestations, problems of diagnosis and treatment of psychopathological disorders using the example of clinical observation of somatoform disorder in a young man with gastroenterological symptoms. Materials and methods: the patient’s diagnosis corresponded to ICD-10 code F45.3 Somatoform dysfunction of the autonomic nervous system. Clinical-anamnestic, clinical-psychopathological, laboratory and instrumental methods were used. This clinical case demonstrates certain difficulties in diagnosing and treating somatoform disorders due to the need to exclude somatic pathology, nonspecific and difficult to differentiate symptoms that are not subjectively realized by the patient, individual selection of therapy and low compliance with it, and the need for psychotherapeutic assistance.
Possibilities of using telemedical interventions in the framework of providing specialized endocrinological care to the population
Authors: Treneva E. V. , Bulgakova S. V. , Fatenkov O. V. , Kurmaev D. P. , Nesterenko S. A.
Published: February 2025

Telemedicine is the use of telecommunication systems to provide medical care to the population at a distance. It has the potential to improve patient outcomes, access to care, and reduce health care costs. As telemedicine consultation applications continue to evolve, it is important to understand in which clinical situations and settings of care a telemedicine intervention is appropriate and can ensure that patients receive quality care. Objective: to assess the acceptability, effectiveness and safety of using TMC in the provision of specialized endocrinological care to patients. Search strategy: review of the most relevant studies published in the electronic databases Medscape, PubMed, PubMed Central, MEDLINE, Scopus, eLibrary, CyberLeninka. The selection criterion was scientific articles published up to March 2024 inclusive. Search keywords: telemedicine, virtual care, endocrinology, diabetes. Conclusions. The results of currently published studies have shown that telemedicine interventions can have a beneficial effect on the outpatient management of patients with chronic non-communicable diseases, in particular diabetes mellitus, and improve the self-management of glycemic parameters in patients. However, many questions remain unresolved regarding the choice of the optimal strategy for monitoring, treating and providing quality medical care to patients with endocrine pathology. Findings to date indicate significant promise for implementing telemedicine interventions within health care delivery. The advisability of their use in each specific case must be approached individually and solely as another, additional tool for improving the quality and accessibility of medical care.
Relationship between levels of inflammatory markers and the degree of obesity in patients with metabolic syndrome
Authors: Pashentseva A. V. , Vukolova Yu. Yu. , Gubareva I. V. , Savelyeva N. V.
Published: February 2025

Currently, metabolic syndrome (MS) is interpreted as a symptom complex of disorders of carbohydrate and lipid metabolism and arterial hypertension. Impaired carbohydrate metabolism or insulin resistance with a decrease in the sensitivity of peripheral tissues to insulin provokes the accumulation of visceral fat, which in turn initiates systemic inflammation. Obesity is clearly associated with cardiovascular pathology with progression of risk and development of diabetes mellitus. Aim is to identify the relationship between traditional markers of inflammation and interleukins -8, -10 with the degree of obesity in patients with MS. Materials and methods: the study included 160 male patients with MS and hypertension. Depending on the degree of obesity, patients were divided into 5 groups: the number of subjects in group 1 (n=36), in group 2 (n=76), in group 3 (n=39), in group 4 (n=6) and in group 5 (n=3). All patients with hypertension of 1-3 degrees, with the target blood pressure level achieved. The age of the subjects was 31-65 years. All patients underwent: collection of complaints and medical history, assessment of body mass index (BMI); determination of lipid spectrum, blood glucose. Microalbuminuria and glomerular filtration rate were determined. Interleukins 8, 10 were determined using the ELISA method. Instrumental studies were performed: ABPM, echocardiography. Results: when assessing traditional risk factors, the following was revealed: a direct relationship between the degree of obesity and BMI (r=0.94; p=0.001), with TG levels (r=0.34; p=0.001), with blood glucose levels (r=0 .24; p=0.004), inverse with MAU (r= -0.92; p=0.003) and direct with SBP level (r=0.35; p=0.0007). Inflammation indicators CRP and ESR were correlated with IL-10 levels, which is associated with activation of anti-inflammatory activity (r=0.83; p=0.01; r=0.78; p=0.02, respectively). Heredity and smoking also determined their contribution to the initiation of inflammation - direct relationships were identified with CRP and fibrinogen levels (r=0.30; p=0.04; r=0.36; p=0.01). Correlation analysis of echocardiography data showed that correlations between LVMI and age were identified (r=0.494; p=0.0001); duration of hypertension (r=0.504; p=0.0001); with blood glucose level (r=0.242; p=0.047).
Role of adipose tissue and obesity in the development of reproductive disorders in women
Authors: Kosareva O. V. , Bulgakova S. V. , Dolgikh Yu. A. , Sharonova L. A. , Treneva E. V. , Kurmaev D. P. , Merzlova P. Ya.
Published: February 2025

In recent decades, obesity has been a pressing medical and social problem for all countries, including the Russian Federation. Obesity is an independent risk factor for the development of many chronic diseases, including reproductive and metabolic disorders. The article presents data on the prevalence of obesity among women. The effect of adipose tissue on reproductive function is shown - on ovarian function, on the endometrium, as well as on the activity of the hypothalamic-pituitary-ovarian system. The relationship between obesity and polycystic ovary syndrome, infertility, and metabolic menopausal syndrome is discussed. The mechanisms of the impact of obesity on the pathogenesis of reproductive disorders in women are considered.
Correction of nutritional status in a comprehensive program for the prevention and treatment of sarcopenic obesity
Authors: Chainikova M. A. , Kurmaev D. P. , Bulgakova S. V. , Treneva E. V.
Published: February 2025

Sarcopenic obesity is a complex condition characterized by a combination of obesity and sarcopenia. This pathology has a significant impact on the health and quality of life of the elderly and old people, increasing the risk of chronic diseases and impairing physical functions. Nutritional status plays a key role in maintaining the health and functional ability of older people, influencing the development of sarcopenia and obesity. Understanding the relationship between sarcopenic obesity and nutritional status is critical for developing prevention and treatment strategies. Our scientific article covers the various mechanisms of development of sarcopenic obesity and the influence of nutritional status on sarcopenic obesity, and also examines the role of various nutrients and dietary supplements in the management of this condition. Our scientific article highlights the need for a comprehensive approach to the treatment and prevention of sarcopenic obesity among elderly and elderly patients to improve overall health and quality of life.
Genetic aspects of celiac disease
Authors: Rosina M. A. , Trapeznikova A. Yu. , Khavkin A. I. , Yablokova E. A.
Published: February 2025

Today, among chronic immune-mediated systemic diseases, celiac disease, or gluten enteropathy, occupies one of the leading places in terms of the degree of study and development in gastroenterology and therapy. Despite these facts, celiac disease is of interest from the point of view of scientific research, as a direct correlation between the disease and the genetically determined component has been proven, research in the direction of which promises doctors to find preventive points of impact in combination with knowledge of immunobiology and genetics. The purpose of this literary review is to analyze current literary data on this topic. Materials and methods. Modern scientific articles published in the period from 2019 to 2024 were collected and analyzed. Information was searched in the databases Pubmed, Scopus, Elibrary, Global Health, CyberLeninka. Results. The presence of HLA risk alleles is a necessary, but not the only genetic factor for development. HLA typing has great predictive value, and the absence of HLA-DQ2/-DQ8 excludes the presence of celiac disease in those predisposed to it. Additional non-HLA genomic loci identified as associated with celiac disease probably explain the additional 32% of genetic heritability. Speaking in general terms, the presence of gluten in the diet is a necessary factor. At the same time, celiac disease does not develop without gluten, even if there is a genetic predisposition. Discussion. The PubMed biomedical knowledge search engine, at the beginning of August 2024, contains 10 111 publications on gluten enteropathy over the previous ten years, and 4804 in Elibrary. An analysis of the topics of articles in recent years suggests that the main focus is on the genetic and immunobiological aspects of the disease in the age aspect, aimed at a greater.
Prevalence of genetic markers of celiac disease in different populations
Authors: Yankina G. N. , Kondratieva E. I. , Loshkova E. V.
Published: February 2025

Despite the fact that celiac disease has been described for a long time, the role of genetic factors and mechanisms of predisposition and/or resistance to celiac disease has not yet been fully determined. Factors such as the presence of HLA (heterodimers of DQ2 and DQ8) and gluten as a trigger are necessary but not sufficient for the development of celiac disease. This statement is supported by studies showing that celiac disease has been diagnosed in patients without the presence of any recognized risk factors. For a long time, celiac disease was considered rare in Asia, but several studies published over the past two decades have shown that CD is detected and as widespread in the Indian subcontinent and the Middle East as in Western countries. Among the Far Eastern countries, reports of CD are particularly rare in both Korea and Japan, but the incidence of the disease in these countries is steadily increasing. Of great interest is the analysis of the prevalence of HLA haplotypes in the Japanese population, as an example of a “non-classical” population, in which the frequencies may not correspond to those described for Western Europe. Thus, an increase in the number of genome-wide studies and sample sizes allows not only to map new regions of predisposition to the genetic map of celiac disease, but also new genetic variants of already known genes, as well as new genes, which in turn allows us to identify and detail already known mechanisms of development and progression of the disease on the way to its therapy.
GM1 - gangliosidosis, type 1 in the practice of a clinical laboratory diagnostics doctor
Authors: Konyukhova T. V. , Mandzhieva A. I. , Trukhina E. V. , Guruleva L. B.
Published: February 2025

GM1- gangliosidosis is a rare hereditary disease from the group of lysosomal storage diseases, caused by a deficiency of the enzyme beta-galactosidase and leading to an abnormal accumulation of metabolic byproducts. GM1 - gangliosidosis is accompanied by a number of cytological disorders: multiple vacuoles in lymphocytes; weakly stained, unevenly distributed granules and cytoplasmic vacuolization in eosinophils. The article presents a clinical case of GM-1 - gangliosidosis type 1 in a 5-month-old child, which became possible to assume from the study of bone marrow (BM) and peripheral blood smears. Detection of vacuolated lymphocytes and abnormal eosinophils in the study of leukocyte formula may have important diagnostic value in patients with metabolic disorders.
Quality of life of children who have had infectious diseases of the respiratory, gastrointestinal tracts and HIV infection
Authors: Nikulina I. A. , Trendeleva T. A.
Published: February 2025

In the article the authors consider the problem of studying the quality of children’s life who have had infectious diseases of the respiratory (acute and recurrent) and gastrointestinal tracts (rotavirus infection and chronic hepatitis C), as well as HIV-infection. The relevance of such studies is due to the significant role of infectious pathology in the structure of childhood morbidity, especially acute infections of the upper respiratory tract of multiple and unspecified localization, as well as acute intestinal infections. The methodology of using specially designed questionnaires for children and their caregivers presented, allowing for a comprehensive assessment of various aspects of their quality of life.
Longer Single-Session Interventions may not be Better: Evidence From two Randomized Controlled Trials With Online Workers Facing Mental Health Struggles
Authors: Kaveladze Benjamin , Ghosh Arka , Funkhouser Carter J. , Schueller Stephen M. , Schleider Jessica L.
Published: February 2025

Online self-guided single-session interventions (SSIs), which provide a complete mental health intervention in one brief experience (typically 20-30 minutes), promise to increase global access to evidence-based support. One way to expand current SSIs’ reach is to shorten them, but doing so could also compromise their effectiveness. We conducted two randomized trials to test if shortening evidence-based SSIs reduces their effectiveness among adult online workers facing mental health struggles. In study 1 (n = 262), an 8-minute SSI reduced loneliness over eight weeks more than a 23-minute version of it did (b = 2.64; d = 0.22; 95% CI 0.02, 0.41; p = .03). In study 2 (n = 1,145), a 15-minute, 9-minute, 5-minute, and 3-minute version of an SSI did not significantly differ in how much they affected depression eight weeks later (ps > 0.14). Our results suggest that longer SSIs are not necessarily more helpful than shorter ones.
Intolerance of aloneness as a prospective predictor of suicidal ideation during COVID-19
Authors: Lewis Katie C , ROCHE MICHAEL J , Brown Fiona , Tillman Jane
Published: February 2025

Background: Social distancing has been essential in mitigating the spread of the SARS-CoV-2 virus. Evidence regarding the impact of reduced social contact on mental health during the pandemic has been mixed, however, with studies suggesting that enduring personality traits and affect regulation impairments may together increase risk for suicidal distress during periods of lockdown. The present study utilized experience sampling and longitudinal follow-up methods to evaluate intolerance of aloneness (IA) as a predictor of suicidal ideation (SI) during the pandemic. Methods: A general adult sample (n=184) recruited online completed an 8-week experience sampling protocol via smartphone between April and September 2020. A subset of n=69 participants completed a follow-up assessment of SI six months after the initial study period. Results: IA was associated with suicidal ideation both at baseline and prospectively during the experience sampling period. Individuals with greater IA were more likely to report SI in the short-term context of reduced daily in-person social contact. Higher IA at baseline furthermore prospectively predicted the occurrence of SI during the 6-month follow-up period. Limitations: The sample was relatively homogenous in terms of demographic characteristics and excluded individuals with limited access to communication technology. While statistical models accounted for the impact of clinical status, other factors that were not assessed (such as adverse events) may have contributed to the development of SI. Conclusions: Findings enhance understanding of how personality-based factors may contribute to suicide risk during periods of social distancing, informing both clinical treatment, risk assessment, and public health intervention approaches.
Personalized prognosis & treatment using an optimal predictor machine: An example study on conversion from Mild Cognitive Impairment to Alzheimer's Disease
Authors: Porta Mana PierGianLuca , Rye Ingrid , Vik Alexandra , Kociński Marek , Lundervold Astri Johansen , Lundervold Arvid , Lundervold Alexander Selvikvåg
Published: February 2025

The present work presents a statistically sound, rigorous, and model-free algorithm for use in personalized medicine. The algorithm is designed first to learn from a set of clinical data with relevant predictors and predictands, and then to assist a clinician in the assessment of prognosis & treatment for new patients. It allows the clinician to input, for each new patient, additional patient-dependent clinical information, as well as patient-dependent information about benefits and drawbacks of available treatments. For this reason we call it an "optimal predictor machine". We apply this machine in a realistic setting for clinical decision-making, incorporating clinical, environmental, imaging, and genetic data, using a data set of subjects suffering from mild cognitive impairment and Alzheimer’s Disease. We show how the algorithm is theoretically optimal, and discuss some of its major advantages for decision-making under risk, resource planning, imputation of missing values, assessing the prognostic importance of each predictor, and further uses.