bluuebunny/crossref_metadata_2025 huggingface dataset:
CAR-T Cell Therapy: Pioneering Immunotherapy Paradigms in Cancer Treatment
Authors: Borah Dhitri , Hojaisa Sibasree , Sarma Indira , Mavi Anil Kumar , Singh Tejveer , Gulati Anita , Goswami Ravi Kumar , Maru Saurabh
Published: January 2025

The world's one of the major causes of death are cancer. Cancer is still a complex
disease over the years that needs to be cured. Traditional cytotoxic approaches, although they
have been implemented for years for treating neoplastic diseases, yet are limited due to the intricacy
and low efficiency of cancer cells. Researchers are thus compelled to seek more potent
therapeutic strategies. Chimeric antigen receptor (CAR-T) cell therapy is one such innovative
insight where T lymphocytes are altered genetically to target cancer cells. Despite the outstanding
accomplishment in patients with haematological malignancies, CAR-T cell treatment has
demonstrated minimal impact on solid tumours due to a number of obstacles, including proliferation,
stability, trafficking, and fate within tumors. Furthermore, interactions between the host
and tumour microenvironment with CAR-T cells significantly alter CAR-T cell activities. Designing
and implementing these treatments additionally also requires a complex workforce.
Overcoming these significant challenges, there is a requirement for innovative strategies for
developing CAR-T cells with greater anti-tumour efficacy and reduced toxicity. In this chapter,
the current advancement in CAR-T cell technology in order to increase clinical efficacy in both
solid tumors and haematological, as well as possibilities to conquer the limits of CAR-T cell
therapy in both solid and haematological tumours has been discussed.
Insight of Intestinal Fatty Acid Binding Protein as a Potential Biomarker in the Biology of Epithelial Damage of Gastrointestinal Membrane
Authors: Rehman Nahid , Pandey Anjana
Published: January 2025

The diagnosis of intestinal injury remains a challenge as it is rare in occurrence and
transpires in multiple traumatized patients. The deferred finding of injury of intestines upsurges
multiple risks such as septicemia, numerous organ failures as well as mortality. In this review, we
corroborate with the goals of proposing surrogate biomarkers that consent to the measurement of
the permeability of intestines more effortlessly. The expression of intestinal fatty acid binding protein
(I-FABP) is exclusive in the intestine and has beenreported to release extracellularly upon damage
caused to tissues. This work focuses on evaluating the legitimacy of I-FABP as an initial biomarker
to distinguish abdominal damage predominantly from an injury to the intestine.
Understanding Tankyrase Inhibitors and Their Role in the Management of Different Cancer
Authors: Das Sinjini , Byran Gowramma , Biswas Kaushik , Rajagopal Kalirajan
Published: January 2025

Cancer manifests as uncontrolled cell proliferation. Tankyrase, a poly(ADP-ribose) polymerase member, is vital in Wnt signal transmission, making it a promising cancer therapy target. The Wnt/β-catenin pathway regulates critical biological processes like genomic stability, gene expression, energy utilization, and apoptosis. Its dysregulation contributes to cancer development. Targeting tankyrase within this pathway holds the potential for inhibiting aberrant cell growth and promoting programmed cell death, offering a promising avenue for cancer treatment. ADP-ribosylation, a reversible process, modifies proteins post-synthesis, regulating diverse cellular signaling pathways. Transferase enzymes like mono and poly(ADP- ribosyl) transferases transfer ADP-ribose from NAD+ to specific amino acid side chains or ADP-ribose units on target proteins. Blocking tankyrase has emerged as a promising strategy in cancer treatment. This article reviews recent advancements in developing novel tankyrase inhibitors. It delves into structure-activity relationships, molecular docking, polypharmacology profiles, and binding mechanisms at the active site. Insights into lead structure development aid in designing potent anti-cancer medications, shedding light on promising avenues in cancer therapy.
Beyond CTLA-4 and PD-1: Novel Insights into MAO-A as a Next- Generation Immune Checkpoint Modulator for Cancer Immunotherapy
Authors: Maity Prajna , Sur Debjeet
Published: January 2025

Immune checkpoint blockade (ICB) has fundamentally transformed cancer treat-ment by unlocking the potency of CD8+ T cells by targeting the suppression of the CTLA-4 and PD-1/PD-L1 pathways. Nevertheless, ICBs are associated with the risk of severe side effects and resistance in certain patients, driving the search for novel and safer immune check-point modulators. Monoamine Oxidase A (MAO-A) plays an unexpected role in the field of cancer. Recent research has unveiled its dual nature: in the brain, it breaks down neurotrans-mitters, impacting mood and behaviour, while in tumours, its role takes a more complex turn. The involvement of MAO-A in the tumour microenvironment is crucial, affecting oxidative stress, hypoxia, and immune cell behaviour. Specifically, the regulation of tumour-associated macrophages (TAMs) and their polarisation underscores their potential as targets for cancer immunotherapy. MAO-A inhibition reprograms TAMs, shifting them from an immunosup-pressive to an immunostimulatory state, thereby enhancing the activity of tumour-infiltrating CD8+ T cells. Interestingly, the presence of MAO-A in CD8+ T cells suggests its potential as a target for novel ICB therapy. This review lays the groundwork for a deeper understanding of the therapeutic potential of MAO-A by examining the intricate landscape of its role in cancer immunology. We envision a future in which harnessing the power of CD8+ T cells through optimised MAO-A targeting might lead to safer and more effective cancer treatments, offering hope for countless patients.
In Silico Analysis of Antarctic Rhomboid Proteases (Rho): Unveiling
Protein Structure and Evolution
Authors: Al-Shomali Belal , Daniel Abdullah Muhd Danish
Published: January 2025

Background: The stability of Rho depends on its amino acids, protein structures, oligomerization,
strong interactions, salt bridges, and bonding patterns. A single amino acid change
can alter the protein's tertiary structure. Rhomboids cut misfolded membranes. They regulate protein
synthesis, mitochondrial integrity, parasite invasion, and growth factor secretion. Research into
these proteins and their inhibitors can improve therapeutic targeting of the Rho protein, which reduces
type II diabetes and Parkinson's disease.

Objective: The primary aim is to examine Antarctic Rho sequences, amino acid contents, and active
domains. Additionally, modeling tools will be used to build three-dimensional Rho structures from
extremophiles. Docking simulations determine the predicted proteases' proteolytic and aminopeptidase
activity.

Methods: PATRIC discovered Antarctic Rho—MAFFT-aligned structures. Meanwhile, Inter-
ProScan and ProtParam determined the amino acid content and active domain. To foretell the 3D
structure of proteins, I-TASSER, CB-Dock, and Discovery Studio were used.

Results: Rhomboid gene alignments amongst Antarctica isolates show that protein evolution was
limited at cold temperatures. All isolated proteins had similar active domains and amino acid sequences.
Rhombic structure and proteolytic activity have not changed appreciably across evolution.
A spatial arrangement of Rho reduces resilience. Antarctic Rho contained critical amino acid residues
LEU (292, 251, 252, 289) and ALA 304.

Conclusion: Antarctic isolates' Rhomboid alignment demonstrates restricted evolution, possibly via
bacterial horizontal gene transfer. Despite multiple actions, active domain presence is maintained
physically and functionally. Bacterial Rhomboids are therapeutic targets due to their rising role in
various illnesses.
S100A8 and S100A9–Critical Mediators of Inflammation in Arthritis
Authors: Paramasivam Sivasakthi , Perumal Senthamil Selvan , Ekambaram Sanmuga Priya
Published: January 2025

Damage-associated molecular Patterns (DAMP) released on the onset of tissue injury
interact predominantly with pattern-recognizing receptors (PRRs) and multiple receptors to trigger
and mediate inflammation and play a critical role in the progression of various diseases. Among
the multiple DAMPs, S100A8 (MRP-8) and S100A9 (MRP-14) are low molecular weight calcium-
binding proteins primarily expressed in innate immune cells such as myeloid cells: neutrophils,
monocytes, keratinocytes, and early differentiation states of macrophages giving them
the name Myeloid related proteins (MRP). S100A8 and S100A9 can exist both as homo- and heterocomplexes
– shown to elicit different functions in cellular physiology, chemotaxis, phagocyte
migration and modulation of various macrophage functions, apoptosis in cancer, and activation of
NF-κB pathway. S100A8 and S100A9 have been shown to trigger innate immunity via TLR-4 signaling,
thereby increasing the production of proinflammatory cytokines and other downstream effectors
of the cascade. An influx in S100A8 and S100A9 proteins has been implicated in the most
prevalent arthritic conditions, such as rheumatoid arthritis (RA) and osteoarthritis (OA). Hence,
the primary objective of the review is to provide a comprehensive and systematic analysis imparting
insights into the role of S100A8 and S100A9 proteins as mediators of inflammation in RA and
OA.
A Review of the Protective Effects of Rosemary and its Main Ingredients Against Cancer by Modulating Nrf2 Signaling
Authors: Amiri-Ardekani Ehsan , Radfar Amirreza , Tavakoli-Far Fatemeh , Farkhondeh Tahereh , Aschner Michael , Samini Fariborz , Samarghandian Saeed
Published: January 2025

Rosemary, as a medicinal plant, contains valuable compounds such as rosmarinic acid,
rosanol, caronic acid, and carnosol. In this study, we summarized and summarized studies related
to the anticancer effects of rosemary and its main ingredients by activating Nrf2. For this purpose,
we searched the main databases including Scopus, PubMed, Web of Science, and MEDLINE until
2024. It was found that Rosemary and its main ingredients affect Nrf2 signaling activity, a pathway
that is induced in response to oxidative stress conditions to reduce reactive oxygen species
(ROS). Nrf2-related effects of Rosemary and its main ingredients have been studied in different
models of diseases, including cancers. These compounds also induce apoptosis and increase antioxidant
enzyme activity downstream in favor of cancer cell line death. The induction of Nrf2 activity
via activating protein kinase RNA-like endoplasmic reticulum kinase results in increased
phosphorylation at site threonine, downregulation of iNOS, enhancement of nerve growth factor,
and activating transcription factor 4 protects cells against carcinogenesis.
The Impact of Health Literacy on Knowledge, Attitude, and Practice Toward COVID-19 among Elderly Women: A Cross-Sectional Study in Iran
Authors: Ranjbar Afsaneh , Rahmani Ali Hasan , Mohamadi Solmaz , Abedi Parvin , Rahmanian Vahid , Javadifar Nahid , Jamali Safieh
Published: January 2025

Background and Objectives:

The coronavirus has become a significant danger to human
health. Health literacy is a major factor influencing health outcomes. The aim of this study was to
assess health literacy and knowledge, attitude, and practice (KAPs) toward COVID-19 among elderly
women.

Methods:

This descriptive-analytical study was conducted on elderly women living in Jahrom City
in 2022. Participants responded to questions regarding sociodemographics, the Health Literacy
Scale, and a researcher-developed knowledge, attitude, and practice (KAP) questionnaire. Descriptive
statistics, one-way analysis of variance, independent sample T-test, Tukey post hoc test, and
multiple linear regression were employed to analyze the data.

Results:

The study participants had a mean age of 69.73 ± 7.17 years, with 38.53% aged over 70
years. Notably, 83.3% of participants expressed trust in information from friends and relatives. The
average health literacy score among the women was 75.79 ± 20.36, and 40.7% had high health literacy,
25.3% had adequate health literacy, 18% had somewhat insufficient health literacy, and 16%
had inadequate health literacy. The majority, 96%, had good awareness, 94.7% had a positive attitude,
and 87.4% had good performance regarding the prevention of COVID-19. The results revealed
that an increase of one unit in knowledge and practice scores corresponded to a respective
increase of 0.485 (p<0.001) and 0.274 (p=0.001) in the average health literacy score. Furthermore,
age (<0.001), education (<0.001), and occupation (<0.001) of participants were significantly associated
with knowledge and practice related to COVID-19.

Conclusion:

The study findings underscored the positive correlation between high health literacy
and individuals' awareness, practices, age of women, education, occupation, source of information,
and marital status. Enhancing people's awareness emerges as a key strategy to bolster health literacy
levels in the population.
In vitro and In silico Degradation Study Applied to the Carbapenems Meropenem and Imipenem
Authors: Carlos Graciela , Barbosa Fábio de Souza , Piton Yasmin Vendruscolo , Garcia Solange Cristina , Arbo Marcelo Dutra , Paula Fávero Reisdorfer , Garcia Cássia Virginia , Steppe Martin , Mendez Andreas Sebastian Loureiro
Published: January 2025

Background:

Imipenem and meropenem are the carbapenem antibiotics most commonly
used for the treatment of severe bacterial infections. Their stability behavior, which focuses on degradation
products, has been continually reported. Strategies based on in silico prediction have been
explored as an additional tool that provides additional information about drug stability.

Methods:

A comparison between experimental and predictive data, with a focus on stability and
degradation products, was performed by examining the literature data and the in silico results. The
experimental data were obtained from the literature throughdatabase searches. The in silico degradation
prediction was performed through the software Zeneth 9.0, which strictly focused on degradation
products. With a focus on stability, degraded samples of meropenem and imipenem were investigated
in terms of biological safety, applying an in vitro cytotoxicity assay by MTT reduction and
neutral red uptake.

Results:

From the literature survey, it was found that 11 major degradation products for both carbapenems
mainly formed from modifications on the b-lactam ring and dimerization. By using the
Zeneth software, a large number of substances were predicted, considering the probability of occurring
and the selected stressors. Even in low numbers, the comparative results indicated similarity in 4
degradation products, with high probability. About cytotoxicity, the cell viability by MTT assay was
significantly reduced for imipenem samples degraded during 4 hours. For meropenem, applying
neutral red uptake assay, a reduction of cell viability was observed in samples stored for 4 hours.

Conclusion:

Drug stability assay includes different approaches, which can be used favorably from
the interaction between all areas of interest, including experimental practice and predictive modelling
assay.
Recent Advancements in Inductively Coupled Plasma Mass Spectrometry in Trace Element Analysis
Authors: Barik Pallavi , Mehta Ashish , Makhija Rahul , Saha Moumita , Asati Vivek
Published: January 2025

Coupled Plasma Mass Spectrometry (ICP-MS) has emerged as a powerful analytical technique
for trace element analysis, finding widespread applications across diverse fields such as pharmaceuticals,
food safety, and biological sciences. This technique is known for its exceptional sensitivity
and capability to measure multiple elements simultaneously. Moreover, it provides critical
insights into heavy metal and trace element content in diverse matrices, making it an indispensable
tool in scientific research and regulatory compliance. Also, it plays a pivotal role in ensuring compliance
with regulatory standards and safeguarding human health and the environment. Its sensitivity,
versatility, and ability to provide accurate elemental analysis make it an invaluable tool for researchers,
regulators, and industries alike. As technological advancements continue, addressing challenges
and refining methodologies will further elevate the capabilities of ICP-MS in trace element analysis.
The review discussed the various research performed using ICP-MS to detect heavy metals in raw
materials, APIs, excipients, packaged food, seafood, blood samples, human hair, etc. Further, it mentioned
the impact of higher concentrations of toxic metals on human health. This article provides a
concise overview of ICP-MS, encompassing its principles, applications, and challenges, and highlighting
its pivotal role in various fields.
Optimization of Preparation Conditions of Coconut Shell-based Activated Carbon Using H3PO4 and Zncl2
Authors: Raut Ekta R , Bedmohata (Thakur) Monita A , Chaudhari Archana R
Published: January 2025

Introduction:

This research focuses on the valorization of lignocellulosic biomass in the
form of activated carbon, which can be further utilized for adsorption studies. Presently, waste generated
during cultivation, livestock production, and aquaculture is treated by conventional disposal
methods like landfilling, open-field burning and composting, which leads to land contamination and
air pollution. Moreover, a potential material like lignocellulosic biomass present in agricultural waste
has not been utilized properly despite its many advantages.

Methods:

Bio-based circular economy signifies the use of bio-based waste to produce value-added
products, which will help in minimizing waste. In this research, activated carbon has been prepared
from coconut shells by using two chemical agents such as H3PO4 and ZnCl2. The washed and dried
coconut shells were activated in the temperature range of 600-900°C for 1 hr. The impregnation ratio
of dried shells and activating agents taken was 1:1 to 1:3. The activated material was then washed
and stored for further characterization and adsorption studies. All the obtained products were then
compared to optimize the preparation conditions of temperature and ratio.

Results:

Experimental results revealed that, zinc chloride activation gives better results than phosphoric
acid activation. Even though H3PO4 is also a good activator, it may cause corrosion of the
equipment due to acid and alkali metal attacks. The optimized ratio of impregnation was found to be
1:1 with an activation temperature of 900°C.

Conclusion:

These conditions of ratio discovered the mechanism of ZnCl2 activation. Zinc chloride
activation allows the liquid activating agent to intercalate into the carbon matrix and also extends up
to interlayers of carbon, which consequently produces pores at a temperature above its melting point.
A high amount of activating agent increases the removal of light hydrocarbon and volatile matter due
to collapsing of aliphatic and aromatic bonds, thereby causing weight loss.
The Presence of Nitrosamines and Nitrosamine Drug-Related Substances in Pharmaceutical Products: An Overview of Regulatory Concerns, Analytical Methodologies, and Control Strategies
Authors: Dhansekar Neha , Rale Pratiksha , Ghalsasi yogesh
Published: January 2025

The presence of N-nitrosamine impurities in pharmaceutical products is well known.
In 2019, it resulted in drug recall by the Food and Drug Administration (FDA). Soon, several
groups identified the presence of many N-nitrosamines (NAs) in various Active Pharmaceutical
Ingredients (APIs) and drug formulations worldwide. Moreover, in the last two years, another
type of NAs was identified and detected in several pharmaceutical products. These are easily
formed from the parent drug molecule and are known as Nitrosamine drug-related substances
(NDSRIs). The amine group plays a major and unique role in the synthesis of many drug molecules,
and hence, it is practically impossible to eliminate the presence of NAs and NDSRIs from
drug products. The risk assessment of the health hazard to the patient was done, and the FDA has
set the maximum daily acceptable intake (AI) at 18 ng/day for NAs. This limit poses a significant
challenge in isolating, identifying and quantifying NAs and NDSRIs in APIs and formulations.
For small, simple NAs, a lot of toxicological information and carcinogenetic data is available;
however, for NDSRIs, such data is practically absent. This review article attempts to gather
the toxicological data for a few NAs and NDSRIs and tries to assess the genotoxicity potential of
some NDSRIs. The possible sources of NAs and NDSRIs, including synthetic methodology and
processes, impurities associated with intermediates or raw materials, stability of the API, packaging
materials, imprinting inks, and excipients, are also discussed. A summary of different analytical
techniques used for the detection of these NAs and NDSRIs in different pharmaceutical
products has also been included. Finally, various strategies employed for the minimization of
these impurities along with additional control strategies to mitigate NAs and NDSRIs below acceptable
limits, have also been discussed.
Recent Prospectives of Cellular Signaling Role for Mammary Gland Carcinogenesis
Authors: Kashyap Monu Kumar , Roy Sikma , Jaiswal Shiwani , Verma Shweta , Srivastava Siddhartha , Nigam Amit Kumar , Kumar Awadhesh , Singh Bandana , Tiwari Ved Prakash , Mahima Mahima , Ved Akash , Shukla Karuna S. , Singh Namrata
Published: January 2025

In women globally, breast cancer ranks as the second most frequent cause of cancer-related deaths,
making up about 25% of female cancer cases, which is pretty standard in affluent countries. Breast cancer is
divided into subtypes based on aggressive, genetic and stage. The precise cause of the problem is still unknown.
However, the following significant risk factors have been found: sex, age, heredity, not having children, breastfeeding,
elevated hormone levels, and personal lifestyle. The presence or lack of three nuclear receptors ER, PR,
and HER2/ERBB2 (triple negative) and the amplification of the HER2/ErbB2 gene are the clinical criteria used to
classify breast cancer. Chemotherapy is still the cornerstone of treatment for triple-negative breast cancer
(TNBC), even. If, for the first two groups of patients,receptor-specific therapy is used. The most often prescribed
chemotherapy agents for the treatment of breast cancer include doxorubicin (DOX), curcumin paclitaxel (PTX),
docetaxel (DCX), thioridazine (THZ), disulfiram (DSF), and camptothecin (CPT). Monoclonal antibodies (mAbs)
were used in antibody-drug conjugates (ADCs) to bind tumor-associated target antigens selectively and deliver
very effective cytotoxic agents. According to recent research, synthetic derivatives effectively combat both MCF-
7 and breast cancer cell lines that are resistant to many drugs. This review provides a wealth of information on the
mechanism of action of synthetic derivatives on multidrug-resistant cell lines. This review includes information
about how synthetic derivatives affect cancer cells that have developed multidrug resistance during chemotherapy.
These mechanisms have been linked to factors such as increased drug efflux, genetic factors, growth factors,
increased DNA repair capacity, and elevated xenobiotic metabolism. Because of this, more research is necessary
to learn more about the effectiveness of synthetic derivatives against breast cancer and cell lines that are resistant
to several drugs. This review aims to find recent prospects of various types of cellular signaling pathways
(JAK/STAT, Akt, MAPK, etc.) involved in the progression of breast cancer disorder, and we also study different
synthetic and natural drugs that are applied for treating breast cancer.
CD36 as a Therapeutic Target in Tumor Microenvironment and Lipid Metabolism
Authors: Li Jiaxuan , Chen Jiaqi , Yang Guang , Zhang Shulin , Li Peiyao , Ye Lan
Published: January 2025

Dysregulated lipid metabolism within the tumor microenvironment (TME) is a critical hallmark of
cancer progression, with lipids serving as a major energy source for tumor cells. Beyond their role in cell membrane
synthesis, lipids also provide essential substrates for biomolecule production and activate signaling pathways
that regulate various cellular processes. Aberrant lipid metabolism impacts not only function but also alters
the behavior of immune and stromal cells within the TME. CD36, a key lipid transporter, plays a crucial role in
regulating fatty acid sensing and lipid metabolism, and its dysregulated expression has been associated with poor
prognosis in several cancers. Studies have demonstrated that elevated CD 36 expression in the TME is closely
linked to abnormal lipid metabolism, promoting tumor growth, migration, and metastasis. In recent years, significant
progress has been made in developing CD36-targeted therapies, including small-molecule inhibitors, antibodies,
and nanoparticle-based drugs, with many entering experimental or preclinical stages. This review comprehensively
summarizes the latest advances in understanding the role of CD36 in the TME, focusing on its metabolic
regulatory mechanisms in tumor cells, immune cells, and stromal cells. Additionally, it highlights the contribution
of CD36 to immune evasion, drug resistance, and cancer stem cell maintenance while discussing several
therapeutic strategies targeting CD36, including novel therapies currently in clinical trials. By exploring the therapeutic
potential of CD36, this review provides critical insights for the future development of CD36-targeted
cancer therapies.
Progress on One-dimensional Vanadium Pentoxide-based Nanomaterials for Advanced Energy Storage ANSTEEL Research Institute of Vanadium & Titanium (Iron & Steel), China
Authors: Ni Wei
Published: January 2025

One-dimensional (1D) vanadium-based nanostructures have advantageous properties and
are showing emerging critical applications in the fields of catalysis, smart devices, and electrochemical
energy storage. We herein timely gave an overview of the 1D vanadium pentoxide (V2O5)-based
nanomaterials for these promising applications, especially regarding the merits of different synthetic
methods, structures and properties combined with recent research frontiers in advanced energy storage,
including batteries, supercapacitors and like. The high capacity, high rate and flexibility of 1D
V2O5-based nanomaterials endow them with great potential in high-energy-density, high-power energy
devices and specific/harsh environments. Finally, the directions and suggestions are provided
for further development of this emerging and promising field.
A Robust NSCLC Biomarker- Mir-7-5p: Its In-Silico Validation and Potential SPR-Based Probe for Detection
Authors: Dhara Chandrajeet , Dhara Anindita , Gantayat Saumyatika
Published: January 2025

MicroRNA abundance as a particular biomarker for precisely identifying cancer me-tastases has emerged in recent years. The expression levels of miRNA are analyzed to get insights into cancer tissue detection and subtypes. Similar to other cancer types, the miRNA shows high levels of target mRNA dysregulation in association with non-small cell lung carcinoma (NSCLC). Among many promising cancer biomarkers for NSCLC, miR-7-5p has shown significant down-regulation in the NSCLC tissues and targets proto-oncogenes like PAK2 and NOVA2. The ex-pression levels of different proto-oncogenes targeting the miR-7-5p in NSCLC showed that the EGFR-mutated NSCLC has an experimental validation. The target validation of the miR-7-5p could be analyzed using SPR (Surface plasmon resonance) based sensors at a single nanoparticle level, such as Au nanocube, due to its high specificity and accountability. Despite being an accountable tool for cancer diagnosis, miRNA-based biomarkers sometimes cause poor diagnostic specificity and reproducibility due to their heterogenicity and immunogenicity in cancer detection. To overcome these shortcomings, the biomarkers need to be validated according to recent clinical studies.
Microwave-assisted Synthesis of Quinolines
Authors: Nageswar Yadavalli Venkata Durga , Ramesh Katla , Rakhi Katla
Published: January 2025

Quinoline is a biologically important class of N-based heterocyclic compound. It has attracted
the attention of the researchers since the 19th century. The researchers have identified more
than 600 quinoline compounds to date. Further, these exhibit several biological activities such as
antibacterial, antifungal, antimalarial, antiviral, anti-inflammatory, antiparasitic, insecticidal, and
other activities. Microwave-assisted synthesis is a promising green technique for synthesizing organic
and heterocyclic compounds. The present review provides an overview of the literature available
on microwave-promoted synthetic methodologies for the synthesis of quinoline derivatives that have
appeared in the last ten years. Since the major goal of this work is to highlight the sustainable nature
of microwave-promoted methods, the green features of each research report are presented. It covers
recent synthetic strategies both under homogeneous and heterogeneous catalytic approaches. Significant
decreases in reaction times, enhancement in overall yields, and greater atom economy can be
observed in the documented research. We believe that this work will definitely help in the search for
novel and environmentally benign routes for the synthesis of quinoline-related potential lead molecules.
UPAYA GENERASI MUDA MELALUI KOMUNITAS DALAM MENDUKUNG PELESTARIAN LINGKUNGAN DI JAWA TIMUR
Authors: Diki Angger Arianto  , Aditya Saputra  , Muhammad Zacky Hidayat  , Diva Kartika Putri Pratama
Published: January 2025

Partisipasi generasi muda dalam pelestarian lingkungan memainkan peran krusial dalam mendorong keberlanjutan di Indonesia. Studi ini menggunakan pendekatan analisis permasalahan mitra yang kami lakukan dengan melaksanakan focus group discussion dengan komunitas Environmental Proactive Youth Community Indonesia. Artikel ini membahas bagaimana Environmental Proactive Youth Community Indonesia memobilisasi generasi muda melalui gerakan seperti #ZeroWaste, kampanye Environmental Proactive Youth Community Wave, dan Youth Camp. Studi ini menemukan bahwa dengan pendekatan kolaboratif dan partisipatif, Environmental Proactive Youth Community terus berupaya meningkatkan kesadaran tentang keberlanjutan dan memfasilitasi aksi lingkungan di berbagai daerah. Tidak hanya itu, dampak baik dari gerakan Environmental Proactive Youth Community adalah bahwa inisiatif ini tidak hanya meningkatkan kesadaran lingkungan tetapi juga memperkuat jaringan kolaborasi lintas organisasi. Artikel ini menyimpulkan bahwa pemberdayaan generasi muda melalui komunitas lingkungan dapat menciptakan perubahan positif bagi pelestarian lingkungan.
PENGEMBANGAN KREATIVITAS GURU MELALUI PENDEKATAN NARATIF DALAM PENULISAN ARTIKEL POPULER
Authors: Trisna Andarwulan  , Prima Zulvarina  , Muhammad Hambali  , Millatuz Zakiyah  , Noveria Anggraeni Fiaji
Published: January 2025

Artikel ini bertujuan mendeskripsikan pengembangan kreativitas guru melalui pendekatan naratif dalam penulisan artikel populer di Sekolah Menengah Pertama Muhammadiyah 6 Dau, yang diselenggarakan oleh Unit Pengembangan Karakter Mahasiswa, Universitas Brawijaya. Pelatihan ini dirancang untuk membekali guru dengan keterampilan menulis sebagai sarana menyebarkan nilai-nilai karakter kreatif kepada siswa, sekaligus mendorong guru untuk menjadi agen perubahan dalam dunia pendidikan. Metode pelatihan mencakup berbagai teknik, seperti pengenalan dasar-dasar penulisan artikel populer, penggunaan elemen naratif, refleksi mendalam, dan praktik kolaboratif. Hasil pelatihan menunjukkan bahwa penulisan artikel populer tidak hanya meningkatkan keterampilan literasi dan berpikir kritis guru, tetapi juga menciptakan ruang reflektif yang memperkuat praktik pedagogis mereka. Guru dilatih untuk memanfaatkan elemen naratif dalam menyampaikan ide-ide kreatif secara efektif, memotivasi pembaca, dan memperluas dampak tulisan mereka ke masyarakat yang lebih luas. Diskusi dan kolaborasi selama pelatihan membantu peserta memperkaya perspektif mereka dan meningkatkan kualitas tulisan. Artikel ini menekankan pentingnya pelatihan berkelanjutan dalam mengembangkan kreativitas guru serta mendukung transformasi pendidikan yang lebih inovatif, relevan, dan inklusif.
PENINGKATAN KEMAMPUAN NUMERASI MELALUI MELALUI KEGIATAN PENGOLAHAN SAMPAH ANORGANIK
Authors: Diana Rista  , Hamidah Ulfa Fauziah  , Wikan Sasmita  , Nanda Maharani Sukma
Published: January 2025

Kemampuan numerasi merupakan kesatuan dari pengetahuan, keterampilan, dan tindakan nyata yang dilakukan oleh siswa dengan mengaitkan perhitungan matematika pada setiap kondisi menyesuaikan tujuannya. Konsep dasar dalam numerasi adalah tingkatan satuan seperti satuan panjang, berat, dan volume, yang sering digunakan dalam berbagai konteks kehidupan, termasuk pengelolaan sampah. Metode penelitian yang digunakan yakni kegiatan pengabdian masyarakat yang dilakukan oleh mahasiswa Program Studi Pendidikan Pancasila dan Kewarganegaraan Universitas Nusantara Persatuan Guru Republik Indonesia Kediri bersama dengan siswa dari Sekolah Dasar Negeri 2 Babadan. Kegiatan ini selaras dengan tujuan peningkatan kemampuan numerasi siswa melalui materi tingkatan satuan matematika dan menumbuhkan kepedulian terhadap lingkungan melalui pengolahan sampah anorganik. Melalui pendekatan pembelajaran yang memadukan konsep matematika dengan aktivitas pengolahan sampah, siswa mampu memahami aplikasi praktis dari pengukuran, perhitungan, dan konversi satuan dalam kehidupan sehari-hari. Hal ini meningkatkan pemahaman siswa tentang numerasi secara signifikan. Hasil temuan penelitian yang telah dilakukan bahwa dengan pendekatan integratif ini diharapkan dapat memberikan dampak positif ganda yaitu peningkatan kemampuan numerasi siswa serta peningkatan kesadaran dan kepedulian mereka terhadap lingkungan.
PENGUATAN MUTU PESANTREN MELALUI PELATIHAN PEMBELAJARAN BERBASIS IT BAGI GURU PESANTREN
Authors: Hasyim Amrullah  , Risna Rianti Sari  , M. Anwar Mas'adi  , Azizatiz Zahra
Published: January 2025

Desa Turirejo yang memiliki banyak Pondok Pesantren menunjukkan bahwa tingginya minat masyarakat terhadap pendidikan berbasis agama. Akan tetapi pada observasi awal masih banyak guru-guru yang belum menguasai teknologi dalam pembelajaran yang berdampak pada kualitas dan mutu pendidikan. Penelitian ini bertujuan untuk meningkatkan mutu pendidikan Pondok Pesantren yang ada di Desa Turirejo, Kabupaten malang melalui pelatihan pembelajaran berbasis IT bagi guru-guru pesantren. Penelitian ini menggunakan model ASSURE, yang mencakup analisis karakteristik peserta, penetapan tujuan pembelajaran, pemilihan metode dan media, pemanfaatan bahan ajar, keterlibatan peserta, serta evaluasi dan revisi. Kegiatan ini melibatkan guru-guru Pondok Pesantren di Desa Turirejo, dengan fokus pada pelatihan aplikasi inovatif yang mendukung media pembelajaran. Hasil penelitian menunjukkan bahwa dengan dilaksanakannya pelatihan pembelajaran berbasis IT, para guru mampu menggunakan teknologi sebagai media dalam pembelajaran, yang berdampak positif pada peningkatan kualitas dan mutu pendidikan di Pondok Pesantren. Berdasarkan hasil penelitian dapat dipahami bahwa pelatihan berbasis IT dapat meningkatkan kompetensi guru dan mutu pendidikan pesantren. Sehingga, diperlukan adanya pelatihan lanjutan yang lebih banyak, workshop praktis, serta mentoring dan pendampingan yang berkelanjutan.
System zarządzania bezpieczeństwem w nowoczesnej organizacji – aktualne wyzwania w obszarze przywództwa
Authors: Domżał Piotr
Published: January 2025

Bezpieczeństwo w nowoczesnej organizacji jest jednym z kluczowych elementów warunkujących optymalny rozwój podmiotów a zarządzanie bezpieczeństwem ma pozytywny wpływ nie tylko na zdrowie i bezpieczeństwo pracowników, ale także na ogólną wydajność i konkurencyjność firmy. Analiza wielowymiarowych uwarunkowań bezpieczeństwa organizacji może odnosić się zarówno do przestrzeni podmiotowej, przedmiotowej czy procesualnej. Z uwagi na fakt, iż współczesne organizacje funkcjonują w warunkach rozwijającej i zmieniającej się gospodarki, to zarządzanie nimi wymaga kompleksowego rozpoznania sytuacji aktualnej, prognozowania, ciągłej identyfikacji zagrożeń oraz zarządzania ryzykiem. W obszarze zapewniania bezpieczeństwa, zarządzanie obejmuje umiejętność skoordynowania działań we wszystkich obszarach funkcjonalnych – w tym kontekście istotne znaczenie dla poprawy bezpieczeństwa ma skuteczne przywództwo.
Studium przypadku: Wykorzystanie Robota Emys w nauczaniu języka angielskiego dzieci
Authors: Śmieszek-Formela Lucyna
Published: January 2025

Nauczanie języka obcego stawia przed nauczycielami wyzwania związane z utrzymaniem zainteresowania i zaangażowania dzieci podczas zajęć. Jednym z nowoczesnych narzędzi wspomagających naukę języka angielskiego jest Robot Emys – interaktywny robot stworzony przez polską firmę Flash Robotics. Celem artykułu jest analiza wykorzystania Robota Emys w edukacji dzieci w wieku przedszkolnym na podstawie opinii nauczycielki języka angielskiego, która jako jedna z pierwszych użytkowniczek korzysta z tego innowacyjnego narzędzia, a także rozpoznanie jego zalet i ograniczeń. W badaniu wykorzystano metodę studium indywidualnego przypadku (ang. case study) oraz wywiad z nauczycielką korzystającą z urządzenia. Wyniki badania wskazują, że jest to doskonały środek dydaktyczny, który nie tylko uatrakcyjni lekcje języka angielskiego, ale przede wszystkim ułatwi jego naukę w pełni angażując dzieci w zajęcia.
Carbon Footprint Review in Higher Learning Environment towards Campus Sustainability
Authors: Misni Alamah , Buyadi Siti Nor Afzan , Brahimi Mohamed
Published: January 2025

The greenhouse gas emissions on the campus are directly or indirectly caused by activities or accumulated over the life stages of the product or services, expressed by Carbon Dioxide. The six leading gases that contribute to the carbon emissions in the atmosphere are carbon dioxide (CO2), methane (CH4), nitrous oxide (N2O), hydrofluorocarbons (HFCs), perfluorocarbons (PFCs), and sulphur hexafluoride (SF). This paper aims to identify methods for evaluating the carbon footprint on the campus and its database and creates a theoretical framework for a sustainable campus in the local context of the higher learning environment of Malaysia.
Spatial Identity in the Context of Interior and Building Environment
Authors: Abdul Kadir Syazwani , Aris Nurul Nabilah , Ginting Nurlisa
Published: January 2025

The research paper explores the concept of "spatial identity" within an interior and building environment. It aims to determine how physical and psychological elements contribute to spatial identity in interior design and architecture. The study primarily uses literature review and synthesis, discussing on theories like place identity, sense of place, place attachment, and spatial experience. Key findings suggest that spatial identity is shaped by both physical attributes (such as form, materials, and layout) and psychological elements (like emotional ties and memories). The research concludes that a building’s design can offer meaningful spatial identity through thoughtful integration of these elements.
Efficient degradation of methyl orange through photo-Fenton processes with MIL-100(Fe) modified Fe\(_3\)O\(_4\) (Fe\(_3\)O\(_4\)@MIL-100(Fe)) catalyst
Authors: Puspitasari Melani Puji , Pratama Jeesica Hermayanti , Nugroho Roshid Adi , Lestari Witri Wahyu , Kemala Yusnadia , Saraswati Teguh Endah , Fansuri Hamzah , Mukti Rino Rakhmata , Suharbiansah Rujito S. R.
Published: January 2025

The research successfully synthesized a composite MIL-100(Fe) modified Fe3O4 (Fe3O4@MIL-100(Fe)) catalyst and examined its efficiency in degrading methyl orange (MO) through the photo-Fenton process compared to Fenton. The different percentages of Fe3O4 were integrated into MIL-100(Fe) and their effects on material characteristics and degradation capabilities were studied. Ex-situ synthesis involved varying Fe3O4 weight ratios (3, 10, and 20% w/w). Characterization techniques confirmed the integration of Fe3O4 and MIL-100(Fe) and revealed changes in surface area, pore size, and thermal stability with Fe3O4 addition. Meanwhile, removal tests showed promising results with the photo-Fenton process exhibiting maximum efficiency (95.51%) using 10% Fe3O4@MIL-100(Fe). This study provides valuable insights into developing efficient photo-Fenton catalysts for environmental remediation, particularly for addressing dye pollution in wastewater by highlighting the potential of Fe3O4@MIL-100(Fe) composites in this context.
Modification of Chitosan/PEG4000 dispersed with Lithium Triflate (LiCF\(_3\)SO\(_3\)) as a solid polymer electrolyte for the secondary battery
Authors: Sari Kartika , Haryadi Arifin Nur Muhammad , Khusaenah Nur , Sudaryanto  , Yulianti Evi , Utomo Agung Bambang Setio
Published: January 2025

Secondary battery solid electrolytes attract researchers' attention for being one of the components of the anode and cathode separation in batteries. Currently, battery electrolytes on the market are liquid-based, which have weaknesses in their safety and are not environmentally friendly. Solid-based electrolytes can be a good choice since they excel in the safety and stability of mechanical and electrical properties; however, they still have the disadvantage of low conductivity values (~10-4 - 10-6 S/cm), thus requiring modification. The solid electrolytes modification using chitosan can be done by adding other polymers and salts as fillers and Li+ ion-making agents. This scientific paper offers an overview of the development of chitosan-based secondary battery solid electrolytes with the addition of PEG4000 polymer and LiCF3SO3. The study was conducted using the solution casting method producing solid electrolytes in the form of membranes. The addition of PEG4000 and LiCF3SO3 affected the microstructure and electrical permittivity of the polymer solid electrolyte membrane. PEG4000 as a plasticizer had no significant effect on inter- and intra-molecular bonds due to poor membrane homogeneity; meanwhile, LiCF3SO3 could increase the permittivity and ionic conductivity of the chitosan polymer solid electrolyte membrane to 3.199 x 10-7 S/cm. The chitosan polymer solid electrolyte membrane with the addition of PEG4000 and 30% LiCF3SO3 salt has an optimal value compared to other salt concentration variations.  The results of this research concluded that LiCF3SO3 is evenly dispersed in the chitosan/PEG4000 solid polymer electrolyte membrane enabling it to be used as a secondary battery solid electrolyte.
Klanceng Honey (Tetragonula laeviceps): Its effect on fasting blood glucose, lipid and hematological profiles, and pancreatic histopathology of diabetic rats
Authors: Agussalim  , Umami Nafiatul , Nurliyani  , Wan Ismail Wan Iryani , Masyithoh Dewi , Ustadi  , Agus Ali
Published: January 2025

This study aims to assess the daily ingestion of Klanceng Honey (KH) on fasting blood glucose (FBG), high-density lipoprotein (HDL), total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), and pancreatic histopathology. Thirty rats were involved and divided into six groups: G1 = untreated normal rats, G2 = untreated diabetic rats (DR), G3 = DR treated with 0.9 mg/kg BW glibenclamide, G4, G5, and G6 = DR treated with 1, 2, and 3 g/kg BW KH, respectively for 28 days. The FBG level of G1 was found lower than that of diabetic rat groups (G2–G6) (p<0.01). The TC level of G1 group on 14th and 28th days was lower than that of G2–G6 groups (p<0.01). The TG levels in all rat groups showed no significant difference at 0–28 days. On 14th day, the LDL level of diabetic groups were higher than the one in G1 group (p<0.01). Meanwhile, on 14th and 28th, the HDL levels of G3–G6 groups, were higher than the one in G1 group (p<0.01). The pancreatic histopathology of all rat groups showed no abnormalities of the Langerhans islets. The daily ingestion of KH prevented FBG, TC, TG, and LDL levels from rising, increased the HDL levels, and protected the pancreatic glands against damage. T. laeviceps honey can potentially be used as a functional food for therapy of DM patients.
Enhancing dissolving pulp quality of mixed raw materials through pre-hydrolysis kraft-cooking: A study on Acacia crassicarpa and Terminalia catappa
Authors: Sahan Yusnimar , Rahmi Sri Wahdini , Evelyn  , Herman Syamsu , Chairul  , Khairat  , Ohi Hiroshi , Amri Amun
Published: January 2025

Acacia crassicarpa wood is widely used in Indonesia as a raw material for dissolving pulp (DP) by the kraft-cooking process. Given that Indonesia has a rich variety and abundance of cellulose-rich wood, it is deemed crucial to research alternative raw materials, such as Terminalia catappa wood. As an alternative source of raw material, Terminalia catappa possesses excellent adaptability to various environmental conditions and is easy to grow everywhere. The current research sought to produce DP using the mixtures of materials from these two plant species as raw materials by pre-hydrolysis, kraft-cooking, and Elementary Chlorine Free (ECF) bleaching. The DP produced had ISO brightness > 88%, alpha-cellulose content > 94%, viscosity > 6.2 cP, and pentosan content of 2.54%. The DP quality traits have met the SNI 938:2017 standards for rayon-grade pulp. Acacia Crassicarpa and Terminalia Catappa are the prospective wood mixture for producing high-quality dissolving pulp via the kraft-cooking process.
Novel colored biomass-waste from food industry sector derived hierarchical porous carbon nanofiber for robust symmetric supercapacitor
Authors: Nursyaputri Wan Mery , Fairuzy Zeeva Khalilah , Khumairah Zahra , Yanti Novi , Nursyafni Nursyafni , Apriwandi Apriwandi , Taslim Rika , Taer Erman
Published: January 2025

A major challenge in the use of supercapacitor energy storage applications is optimizing 3D-hierarchical porous and 2D nanofiber structures to improve the electrochemical performance of colored biomass-derived activated carbon (AC). Therefore, this study aims to synthesize AC from Dracaena Angustifolia (DA) leaves and dregs using a sustainable method through chemical activation and high-temperature pyrolysis. AC was designed to be adhesive-free to maintain the true mechanical properties of the precursor. Research results showed that the sample of DA-dregs-KOH shows optimal results with a specific surface area (317.66 m2 g-1). The electrochemical performance of hierarchical porous carbon treated with 1 M H2SO4 electrolyte in a 2-electrode system had a nanofiber structure with the highest specific capacitance (248 F g-1) at 1 A g-1 and energy density (12.96 Wh kg-1) with a coulomb efficiency 84.1%. Based on these results, DA dreg-KOH based porous AC with hierarchical porous morphology shows significant potential to be used as binder-free electrode materials that can produce high-performance supercapacitors as a new renewable and sustainable energy storage solution.