bluuebunny/crossref_metadata_2025 huggingface dataset:
Bone morphogenetic protein (BMP) receptor inhibitor JL5 synergizes with Ym155 to induce AIF-caspase independent cell death.
Authors: Mondal Arindam , NeMoyer Rachel , Langenfeld Elaine , Glover Danea , Scott Michael , Lairson Lauren , Zloza Andrew , Augeri David , Gilleran John , Peng Youyi , Roberge Jacques , Langenfeld John E.
Published: April 2020

Background: BMP is an evolutionary conserved morphogen that is reactivated in lung carcinomas. BMP receptor inhibitors promote cell death of lung carcinomas by mechanisms not fully elucidated. The studies here reveal novel mechanisms by which the “survivin” inhibitor Ym155 in combination with the BMP inhibitor JL5 synergistically induces death of lung cancer cells.Methods: This study examines the mechanism by which Ym155 in combination with JL5 downregulates BMP signaling and induces cell death of non-small cell lung carcinomas (NSCLC) cell lines. Validation experiments were performed on five passage 0 primary NSCLC.Results: We found that Ym155, which is reported to be a survivin inhibitor, potently inhibits BMP signaling by causing BMPR2 mislocalization into the cytoplasm and its decreased expression. Ym155 mediated cell death is not caused by the inhibition of survivin but involves Ym155 binding to mitochondrial DNA leading to depletion of ATP. The combination of Ym155 and the BMP receptor inhibitor JL5 synergistically causes the downregulation of BMP Smad-1/5 dependent and independent signaling and the induction of cell death of lung cancer cell lines and primary lung tumors. Cell death involves the nuclear translocation of apoptosis inducing factor (AIF) from the mitochondria to the nucleus causing DNA double stranded breaks independent of caspase activation, which occurs only when JL5 and Ym155 are used in combination. Knockdown of BMPR2 together with Ym155 also induced AIF localization to the nucleus.Conclusions: These studies suggest that inhibition of BMPR2 together with Ym155 can induce AIF caspase-independent cell death. AIF caspase-independent cell is an evolutionary conserved cell death pathway that has never been targeted to induce cell death in cancer cells. These studies provide mechanistic insight how to target AIF caspase-independent cell death using BMP inhibitors.
MODELLING SUPPORT SYSTEMS FOR SELECTING PROFESSIONS FOR APPLICANTS IN THE CONTENT OF PERSONALIZATION OF EDUCATION
Authors: Gasimov Huseyn
Published: April 2020

Various methods are currently being used in examining the initial “START” knowledge of applicants and their placement for specialties. Studies show that applicants are placed on the decreasing principle in terms of their overall scores at universities. In this case, applicants with a high level of knowledge are placed in the prestigious specialties as medicine and law as they require high results. Though, while applying for other professions, the applicants do not perform enough results on the key disciplines for the profession, they are placed in those professions when the general results enable it. This causes them to face a number of problems while working both in education process and in the industry.

To avoid this problem and to place applicants in a specialty that is more relevant to their level of knowledge, the introduction of an individual approach to the evaluation of initial level of knowledge may be more promising.

This article presents a modeling of the "evaluation – placement" support system for the individual approach to assessing applicants' knowledge and positioning them in relevant specialties. The main goal of the system is to give each applicant the opportunity to choose and study the specialty that is more relevant to their knowledge and skills, as well as to analyze the results for each discipline along with the overall results. The system is implemented using fuzzy logic based artificial neural networks.

The network consists of 100 neurons in the input layer, two hidden layers and one output layer. The number of neurons at the output is the same as the number of specialties taught at university.
DETERMINATION OF MECHANICAL PROPERTIES OF REPAIR MORTARS USING IN SITU METHODS UNDER DIFFERENT CURINGS
Authors: Varzaneh Ali Saberi , Naderi Mahmoud
Published: April 2020

Considering the differences between environmental conditions of concrete structures and laboratory conditions, it is important to determine the parameters of the materials at the site of the structure. One of these materials is cement-based repair mortars due to the damage of concrete structures that may arise due to chemical or physical factors, these structures are required to be repaired. For this reason, in this paper, to determine the strength of repair mortars of different ages and under different Curing, Situ methods "Friction-Transfer" and "Pull-off" were used and the relationships between the Flexural Compressive, Tensile and readings obtained from the above methods on cementations mortars are presented. Experiments were performed on mortars at ages 3, 7, 28, 42 and 90 days under the conditions of "waterlogging", "Curing Agent" and "releasing in the outdoor". The results show the high impact of the process on the Flexural Compressive, Tensile of the repair mortars and the results of the "Friction-Transfer" and "Pull-off" methods. Also, a high correlation coefficient was obtained between the mechanical properties of the mortars and the results of the above tests; it is possible to measure the mechanical properties of repair mortars in situ with high confidence and in situ
Clinical Psychologist in the System of Complex Rehabilitation
Authors: Kozlova N. V. , Rogacheva T. V. , Levickaya T. E. , Tsehmeistruk E. A. , Nazmetdinova D. G.
Published: April 2020

The research substantiates the role of clinical psychologists in the system of comprehensive rehabilitation within the conditions of bio-psychosocial model of rehabilitation. Practical experience and the analysis of scientific literature made it possible to describe peculiarities of modern complex rehabilitation and the problems experienced by clinical psychologists. The authors determined difficulties and characteristics of professional work of rehabilitation psychologist within modern legal terrain. One problem is the lack of professional standard for the profession of clinical psychologist. The other problem is the inconsistency in the use of terms denoting professional specifics. Тhe paper focuses on the specificity of psychodiagnostic and rehabilitative work of a psychologist in the light of changing theoretical basis of rehabilitation and the transition from the International Classification of Disability Disorders and Social Insufficiency to the International Classification of Functioning, Disability, and Health. The authors showed the discrepancy between the theoretical approaches of domestic and foreign psychology to the assessment of mental disorders. New professional tasks of the psychologist are defined taking into account multidisciplinary orientation of rehabilitation process. The paper describes the problems of professional training of clinical psychologists and specifies new educational tasks are specified proceeding from the modern approach to rehabilitation. Positive dynamics in the solution of the declared problem can be found in new legislative initiatives, development of General clinical recommendations for rehabilitation psychologists, scientific publications on psychological rehabilitation, update of educational programs for training clinical psychologists.
Structural-Content Analysis of Existential Theory and its Value for Psychological Consulting
Authors: Kutsenko N. Yu. , Yaroslavtseva I. V.
Published: April 2020

The present research was based on modern psychological studies. The article features the structure and contents of the existential theory. The structure of the theory is presented in the framework of the concept coined by A. V. Yurevich, while its contents are represented in the context of the existential and phenomenological philosophical traditions. The paper focuses on three elements in the structure of the existential psychological theory. The central one includes a generalized image of psychological reality, its central category, corresponding phenomena, basic concepts, the system of relations between them, basic statements, etc. The peripheral elements are represented by theoretical and empirical components. The third component features the implicit part. The generalized image of the psychological reality is represented by the concept of "Dasein", its central category being "the existence". The author described the basic concepts and auxiliary statements of the theory. The basic statements of the theoretical part of the existential approach are the key provisions and principles of existentialism as formulated by J.-P. Sartre. The auxiliary statements belong to A. Camus and V. Frankl. The authors clarify the conceptual formation of existential theory, starting with E. Husserl’s phenomenology and moving on to modern psychology. The authors believe that the establishment of existential theory contributed to the development of the existential tradition in psychological counseling practice.
Moral Foundations vs. Extremist Attitudes in University Students
Authors: Sychev O. A. , Zhikhareva E. V.
Published: April 2020

The paper features relations between extremist attitudes and moral sphere. The study was based on J. Haidt’s Moral Foundations Theory. Most researchers are interested in the problem of right-wing extremist attitudes, e.g. xenophobia, nationalism, religious fanaticism, authoritarianism, etc. However, the existing evidence of the link between such attitudes and some particularities of the moral sphere doesn't take into account modern psychological approaches toward moral. On the basis of moral foundations theory, the authors hypothesized that binding moral foundations may be linked with rightwing extremist attitudes. This hypothesis was tested on 397 university students (women – 83 %). The participants answered the Moral Foundations Questionnaire by J. Graham et al. and Young Men Extremist Attitudes Questionnaire by K. V. Zlokazov. The results of the correlation analysis showed that individualizing moral foundations (Harm and Fairness) were inversely correlated with right-wing extremist attitudes, while binding moral foundations (Loyalty and Authority) showed direct correlation. Such moral foundation as Sanctity showed contradictory correlations with extremist attitudes. Using structure linear modeling the authors demonstrated the significant impact of two moral foundations (Authority and Harm) on extremist attitudes. Authority was associated with a relatively high level of religious fanaticism, xenophobia, and authoritarianism. Care was associated with a low level of fanaticism, xenophobia, and nationalism. The obtained results proved that such violencecondemning values as care and harm avoidance oppose right-wing extremist attitudes. However, such values as respect for authorities and traditions may have potentially negative side effects, e.g. justification and support of right-wing extremist attitudes.
System of Value Orientations of Personality and Social Communities: Structural and Dynamic Model and its Application in Psychological Research and Psychological Practice
Authors: Yanitskiy M. S.
Published: April 2020

The present article is an extended version of the report delivered at the meeting of the Presidium of the Russian Academy of Education. The paper introduces an authentic structural and dynamic model of the system of value orientations of the individual and social communities. The model was tested in a series of psychological studies over the past 20 years. The research objective was to verify the authentic structural-dynamic model of value orientations in psychological research and psychological practice. The author used a wide range of psychodiagnostic techniques, focus group research, questionnaire survey, and authentic methodology for the study of the value structure of mass consciousness, etc. The experiments resulted in a set of data that characterize the features of the selected value types, i.e. adapting, socializing, and individualizing. These value types are characterized by a focus on different in their origin and level of development of the value system. They differ in such significant features as the level of meaningfulness of life, internality, and self-actualization. They also have a distinct specificity of the time perspective and life strategy of the individual, as well as the regulation of social behavior. The revealed psychological characteristics of value types open the possibility of forecasting social behavior, as well as the development of technologies for psychological and pedagogical support of the formation of a Pro-social hierarchy of values. The proposed structural-dynamic model is applicable to the characteristics of individual systems of value orientations and the value structure of mass consciousness of different communities. It can explain the patterns of social behavior of community members. The model can be used in psychological science and practice.
Reference Books on Trade, Merchants, and Entrepreneurship in Siberia in the Second Half of the XIX – early XX Centuries: Historiographical Review
Authors: Klimova O. G.
Published: April 2020

The research objective was to assess the information potential of reference publications on the history of entrepreneurship in the pre-revolutionary Siberia. Pre-revolutionary, Soviet, and post-Soviet scientists published various encyclopedias and reference books on the history of trade, merchants, and entrepreneurship in Siberia in the second half of the XIX – early XX centuries. The reference literature of each period has its own characteristic features. For instance, The Brief Encyclopedia of the History of Merchants and Commerce of Siberia and The Encyclopedic Dictionary of the History of Merchants and Commerce of Siberia are very unusual. The dictionary with its encyclopedic form of presentation is currently the most convenient and popular variant. Directories and encyclopedias reflect the era they belonged to and thus can provide valuable information on the time period. The dictionaries under analysis appeared to contain biographies of people engaged in entrepreneurial activity, definitions of entrepreneurial activities, descriptions of rural settlements, cities, fairs, etc. The study of reference publications significantly expands the existing ideas about the nature of the business development, trade, and economy of Siberia. However, the related historiography still needs further studies.
Legal Concept and Legal Term: Specificity of the Correlation and Definitions (Based on Russian Laws)
Authors: Batyushkina M. V.
Published: April 2020

The present research featured legal concepts and terms in legislative texts. The paper focuses on various approaches to legal concepts and terms, e.g. logical-hierarchical, definitional, structural-semantic, etc. The author proved that the concepts of legal term and legal concept are often synonymous. They have the same nominative function, verbal expression, modification procedure, and variability. In addition, both terms possess legislative definitions. As a result, a legislative text can be understood in broad and narrow sense. The study touched upon the following issues: (a) the institutional functions of legislative definitions (interpretative, differentiating, legal, system-forming); (b) the location of the definition within the legislative text; (c) the main methods for constructing a legislative definition (lists, descriptions, combinations) and defective legislative definitions. The paper describes reasons for the ambiguity of legal concepts (terms) and the variability of their legislative definitions. The research was based on the texts of Russian federal and regional laws, legal dictionaries, and judicial practice. The methods included discursive, categorical, and definitional approaches, as well as induction and deduction and contextual, component, comparative analyzes. The obtained results and conclusions may be used in legislative text studies, as well as by experts in legislative and judicial discourse.
Mythosymbolic Component of the Animalistic Concept Horse (Loshad' / Kon') in the Russian Language Picture of the World
Authors: Bekmurzaeva F. Sh.
Published: April 2020

The research featured concept "horse", which is one of the key archetypal concepts of the Russian culture. The present article focuses on the secondary symbolic constituents that form the structure of the concept. The research objective was to describe symbolic features in the structure of the concept. The material involved sources of the Russian national corpus, Russian folk tales, and other genres of the belles-lettres discourse representing diverse functional styles of the language. The study revealed the ambivalent nature of symbolic categorization of the animal concept in the Russian language through the prism of religious and mythological worldview. The ambivalent nature represented in the bilateral image is in its polar opposition. On the one hand, it is a solar symbol, a symbol of celestial source, and deity. On the other hand, it is chthonic and demonological. Thus, it implies the following symbolic signs: sun; sky; rain; earth; star; month; bird; fire; light; air; red; water; white; gold; another world; age; sea; mountains; death; Kelpie – a water spirit; immortality; black; centaur; Trojan horse; the magic; time of day; number; unity; fertility; spirituality; speed; inspiration, contemplation; loyalty; persistence; fearlessness; luck; chivalry, nobility; purity, and inaccessibility; lust, riot; secrecy, deceit; power; beauty; intelligence; wisdom; power; life force. Ambivalent features revealed on the basis of factual material are invariant, since their historical significance is also actualized in modern linguistic realities. In addition, for the most part they are positively oriented, which indicates the marking and significance of the horse in the consciousness and life of the Russian people.
The Role of Speech Stereotypes in the Organization of French Protest Song Discourse (Chanson Engagée)
Authors: Zheludkova E. G.
Published: April 2020

The research featured the role of speech stereotypes in the formation of the discourse of protest songs, or chanson engagée, in the French language culture. The study included the method of continuous sampling, discursive analysis, and a descriptive method. Stereotype is a ready-to-use idea about a certain social group or phenomena. The research revealed a number of functions performed by speech stereotypes in the discourse of protest songs. Stereotypes appeared to have the following discourse organization function: they establish the horizontal relationship between communicators to create the communicative equality of the sender and the recipient. Their axiological function is in that they create emotional background that affects the mood and feelings of the recipient. Stereotypes create the illusion of objectivity, where judgment is replaced by the "obvious" knowledge, a fact statement. The dramatization function implies a certain collision. The objectification function is realized due to the incorporation of relevance markers in the artistic text fabric, signaling about the problems of society: if people regularly hear about something, they believe that they understand the phenomenon. The function of banalization means that stereotypes simplify the situation. The persuasive function is in the absence of an obvious appeal: songwriters resort to using clichés that are firmly rooted in the world culture.
French Film Titles with Anthroponyms: Translation Issues
Authors: Tkacheva A. N.
Published: April 2020

The research objective was to analyze, classify, and describe the ways of translation of French film titles that contain anthroponyms. Proper names (surnames, nicknames, or pseudonyms) are used to add additional characteristics to the personage or to express some cultural information. The principles of translation of French anthroponyms into Russian include etymological transposition, practical transcription, morphographic method, and transliteration. The anthroponyms do not correspond semantically in different languages. Therefore, they cannot be considered identical equivalents. When translated from French into Russian, anthroponym-containing film titles often lose their stylistic and artistic value, associations, or puns. As a rule, such titles are transformed using reduction, substitution, or addition of some language elements. The transformation serves to correct a seemingly unattractive title, to link the title to the topic and genre, or to achieve commercial success. Titles with pseudonyms and nicknames of French celebrities always undergo some kind of transformation. Sometimes, translators change the title completely or borrow some elements from commercially successful films to attract the attention of the potential audience. The research results can be applied to train specialists of cinema and media industry and teach them French, as well as to develop universal rules of cinema translation.
Staurographic Collection of the Krivoshchyokovo Necropolis (Typology, Semantics)
Authors: Salnikova I. V.
Published: April 2020

The present research featured a collection of cross pendants, obtained in the process of archeological excavations in the village of Krivoshchyokovo. The village was situated on the left bank of the Ob river on the territory of the modern Novosibirsk. The archeological site included a fragment of the foundation of Nikolskaya church (1881) and a Christian necropolis of 384 graves. The excavations yielded a substantial staurographic collection, as rich as the collections of the Ilimsk fortress, Irkutsk churches, or the city of Omsk. The research objective was to structure the information about the Krivoshchyokovo collection of cross pendants. The collection consists of 270 artifacts dated XVIII – late XIX centuries. The items were classified according to shape, semantics, and epigraphic observations. The classification was based on the typology developed by V. I. Molodin for the collection of Ilimsk fortress. The collection was divided into six types of crosses, typical of similar collections of modern time artifacts found in Western and Eastern Siberia. The Krivoshchyokovo collection appeared to contain some unique items, which have no iconographic analogies but are similar in shape. As a result, the typology introduced by the present article proved wider than the typology it was based on. In addition, the author discovered two new types of cross pendants. The fact that one of them may be related to Catholic cross pendants revealed a certain confessional diversity of the local village population.
Militia Forces against Anti-Soviet Agitation, Propaganda, and Provocative Rumors in the Altai Territory in 1941–1942
Authors: Shatilov S. P. , Shatilova O. A.
Published: April 2020

The research featured the implementation of state ideology and legal policy during the World War II. The present paper describes the case of the Altai Territory, where the local militia forces had to struggle against anti-Soviet propaganda and provocative rumors in 1941–1942. The study helped to identify the main reasons that led to such manifestations: the critical situation at the front during the early period of the war; lack of media information about the real state of affairs; distorted information that the disoriented evacuees shared with the local people. Archival materials helped to shed light on the basic forms and methods which the local militia used to combat the rumors. The paper focuses on the means of identification of sources of anti-Soviet propaganda, as well as the peculiarities of criminal prosecution in such cases. During the Great Patriotic War (1941–1945), the militia used various forms and methods to identify sources of anti-Soviet propaganda and provocative rumors. The analysis showed that the militia thoroughly investigated each case, revealing the initial source of anonymous information.
Forecast of streamflows to the Arctic Ocean by a Bayesian neural network model with snowcover and climate inputs
Authors: Rasouli Kabir , Nasri Bouchra R. , Soleymani Armina , Mahmood Taufique H. , Hori Masahiro , Haghighi Ali Torabi
Published: April 2020

Increasing water flowing into the Arctic Ocean affects oceanic freshwater balance, which may lead to the thermohaline circulation collapse and unpredictable climatic conditions if freshwater inputs continue to increase. Despite the crucial role of ocean inflow in the climate system, less is known about its predictability, variability, and connectivity to cryospheric and climatic patterns on different time scales. In this study, multi-scale variation modes were decomposed from observed daily and monthly snowcover and river flows to improve the predictability of Arctic Ocean inflows from the Mackenzie River Basin in Canada. Two multi-linear regression and Bayesian neural network models were used with different combinations of remotely sensed snowcover, in-situ inflow observations, and climatic teleconnection patterns as predictors. The results showed that daily and monthly ocean inflows are associated positively with decadal snowcover fluctuations and negatively with interannual snowcover fluctuations. Interannual snowcover and antecedent flow oscillations have a more important role in describing the variability of ocean inflows than seasonal snowmelt and large-scale climatic teleconnection. Both models forecasted inflows seven months in advance with a Nash–Sutcliffe efficiency score of ≈0.8. The proposed methodology can be used to assess the variability of the freshwater input to northern oceans, affecting thermohaline and atmospheric circulations.
Aportaciones para una epistemología de los estudios sobre fronteras internacionales
Authors: Medina García Eusebio
Published: April 2020

En este artículo proponemos un modelo interpretativo que puede servir como referente para abordar desde una perspectiva interdisciplinar los estudios sobre fronteras internacionales. Dicho modelo, inspirado en la teoría del campo social dinámico o campo sociocultural (Sztompka, 1995) y en los modelos de simulación social basados en inteligencia artificial (Lozares, 2004), se articula en cuatro dimensiones básicas: ideacional, normativa, materialista y agencial. El modelo es dinámico e interactivo y presupone la existencia de relaciones múltiples y complejas entre las cuatro dimensiones del campo, así como de una cierta autonomía en cada una de ellas. Dicho modelo está gobernado, además, por dos vectores fundamentales: espacio y tiempo. La dimensión espacial se refiere tanto al soporte físico y material, al territorio, como a otros aspectos, entre ellos la aprehensión psicológica del espacio y el espacio imaginario. En su dimensión histórica, temporal, consideramos que el modelo evoluciona constantemente sobre un fondo de mismidad suficiente para poder ser estudiado como hecho social. Abogamos aquí por la necesidad de construir una metodológica ecléctica que nos permita alcanzar una conjunción equilibrada entre los aspectos tangibles e intangibles, cuantitativos y cualitativos, macro y micro, interpretativos y comprensivos, singulares y compartidos, funcionales y crítico-racionales.
Sprzeczność uchwały wspólników spółki z ograniczoną odpowiedzialnością z umową spółki a uchylenie uchwały. Glosa krytyczna do uchwały Sądu Najwyższego z 10.3.2016 r., sygn. akt III CZP 1/16
Authors: Herbet Weronika
Published: April 2020

Uchwałą Sądu Najwyższego z 10.3.2016 r. w sprawie o sygn. akt III CZP 1/16 skład orzeczniczy orzekł, że sprzeczność uchwały wspólników spółki z ograniczoną odpowiedzialnością z umową spółki nie jest samodzielną przesłanką uzasadniającą uwzględnienie powództwa o uchylenie uchwały. Celem niniejszej glosy jest prezentacja stanowiska Sądu Najwyższego przyjętego w niniejszej sprawie oraz jego ocena. W oparciu o wykładnię językową, funkcjonalną, systemową oraz historyczną art. 249 § 1 Kodeksu spółek handlowych, podjęta została polemika z poglądem negującym autonomiczny charakter przesłanki sprzeczności uchwały wspólników z umową spółki, jako podstawy uchylenia uchwały wspólników sp. z o.o. Przeprowadzona analiza została również wzbogacona o wątek prawnoporównawczy, odnoszący się do stanu prawnego oraz poglądów orzecznictwa i doktryny w Niemczech.
Antidiabetic and Anticholinesterase Properties of Extracts and Pure Metabolites of Fruit Stems of Pistachio (Pistacia vera L.)
Authors: Lawali Yabo Dambagi , Mehmet Akyuz , Tuba Aydin , Ahmet Cakir
Published: April 2020

:

Five metabolites were isolated by chromatographic methods from the fruit stems
of P. vera and their chemical structures were characterized as masticadienonic acid (1),
tirucallol (2), masticadienolic acid (3), pistachionic acid (4) and inulobiose (5) via FT-IR,
1H-NMR, 13C-NMR, 1D-NMR and 2D-NMR. Pistachionic acid (4), a new shikimic acid
derivative, was isolated from the ethanol extract for the first time. The hexane, chloroform,
ethanol extracts and pure metabolites exhibited antidiabetic properties by inhibiting α-
glycosidase and α-amylase enzymes at different rates. Their inhibitory effects against the α-
glycosidase enzyme were also higher than that of the acarbose (IC50=10.30 mg/mL). Masticadienolic
acid (3) (IC50=0.03 mg/mL), masticadienonic acid (1) (IC50=0.13 mg/mL) and
hexane extract (IC50=0.09 mg/mL) with the lowest IC50 values were found to be most active
substances. Nevertheless, the inhibitory effect of acarbose against the α-amylase enzyme was determined to be
higher than the inhibition effects of the extracts and pure metabolites. According to the IC50 values, the best
inhibitors against the α-amylase were ethanol extract (IC50=5.17 mg/mL), pistachionic acid (4) (IC50=7.35
mg/mL), tirucallol (2) (IC50=7.58 mg/mL) and masticadienolic acid (3) (IC50=8.22 mg/mL), respectively among
the applications. In addition, anticholinesterase properties of the extracts and pure metabolites were investigated
by testing the inhibitory properties against acetylcholine esterase (AChE) and butrylcholine esterase (BChE)
enzymes activities. The results showed that the anticholinesterase properties of all extracts and pure metabolites
were weaker than those of the commercial cholinesterase inhibitors, neostigmine and galantamine, and all applications
reduced the activity of these enzymes at very high concentrations.
SATISFACTION EVALUATION MODEL OF HIGH-LEVEL ATHLETES MANAGEMENT SYSTEM IN UNIVERSITIES OF SICHUAN PROVINCE OF CHINA
Authors: Yudong Tang , Aman Mohd Salleh , Hooi Lim Boon , Siswantoyo Siswantoyo
Published: April 2020

The purpose of this study was to develop a questionnaire to measure satisfaction levels of Sichuan Province high-level athletes with their management systems using field investigation and mathematical statistics. Through the process of sorting and analyzing existing literature and in combination with the results of expert interviews, an ‘initial questionnaire’ consisting of 58 items and 6 dimensions was formed. As first steps, content validity and face validity of the questionnaire were tested. Then, SPSS 24 and Smart PLS 3 were used to carry out exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) respectively. After the unqualified items were deleted, a formal questionnaire comprising 49 items and 6 dimensions was ultimately formed. Reliability and validity tests demonstrated that the questionnaire had good internal consistency reliability and structural validity. By analyzing the structural model, it is found that the model has good prediction accuracy and prediction relevance, and the model fit is also good. Therefore, the evaluation model constructed in this study could be used as a tool for surveying satisfaction levels of Sichuan Province high-level athletes with their university management systems.
Gestão local e seu impacto no desempenho fiscal: análise dos municípios mineiros
Authors: Karruz Ana Paula , Machado Moraes André
Published: April 2020

O estudo busca elucidar e articular a gama de condicionantes do desempenho fiscal local, dimensionar a influência da gestão fiscal municipal nesse desempenho, e descrever como a qualidade da gestão fiscal se distribui entre municípios com diferentes características. Propõe um modelo conceitual e de regressão para o desempenho fiscal, tendo o Índice Firjan de Gestão Fiscal (IFGF) dos municípios de Minas Gerais como variável dependente. A identificação de efeitos apoia-se na natureza longitudinal dos dados (2007-2016) e na modelagem em painel. Transferências voluntárias da União e do governo estadual parecem favorecer o desempenho fiscal local, especialmente via investimentos. Um terço da variação do IFGF não pode ser atribuída às covariáveis e é tomada, por eliminação, como proxy para a qualidade da gestão fiscal. Esta apresenta moderada correlação com a população e mostra sinais de dependência espacial, com concentração de valores altos na região da capital.
Leilões para conversão de dívida em investimento: uma proposta da teoria de leilões para implantação dos termos de ajuste de conduta (TAC) da Anatel
Authors: Bugarin Maurício Soares , Da Fonseca Hélio Maurício Miranda
Published: April 2020

Desde a privatização da Telebrás em 1998, o Brasil tem assistido a uma impressionante expansão nas telecomunicações. Paralelamente, cresceram assustadoramente as dívidas das operadoras de telecomunicação, com elevadas multas regulatórias. Em 2012, a Anatel aprovou a celebração de termos de ajustamento de conduta (TAC) para a conversão de dívida das operadoras em projetos de investimento. A questão crucial é como determinar a taxa de conversão. Este trabalho propõe um mecanismo de leilão para a determinação endógena dessa taxa. Nesse leilão as operadoras propõem taxas de conversão de dívida em um certo investimento, e a operadora que oferecer a taxa mais baixa (menos reais de dívida deduzidos para cada real investido) vence o leilão. Ademais, discute-se como a estrutura sequencial do problema permite desenhar um mecanismo inédito de leilões sequenciais que tem a característica de criar assimetria entre os jogadores, gerando maior bem-estar social e garantindo a implementação dos projetos selecionados.
Predicting COVID-19 Incidence Through Analysis of Google Trends Data in Iran: Data Mining and Deep Learning Pilot Study
Authors: Ayyoubzadeh Seyed Mohammad , Ayyoubzadeh Seyed Mehdi , Zahedi Hoda , Ahmadi Mahnaz , R Niakan Kalhori Sharareh
Published: April 2020

Background

The recent global outbreak of coronavirus disease (COVID-19) is affecting many countries worldwide. Iran is one of the top 10 most affected countries. Search engines provide useful data from populations, and these data might be useful to analyze epidemics. Utilizing data mining methods on electronic resources’ data might provide a better insight into the COVID-19 outbreak to manage the health crisis in each country and worldwide.

Objective

This study aimed to predict the incidence of COVID-19 in Iran.

Methods

Data were obtained from the Google Trends website. Linear regression and long short-term memory (LSTM) models were used to estimate the number of positive COVID-19 cases. All models were evaluated using 10-fold cross-validation, and root mean square error (RMSE) was used as the performance metric.

Results

The linear regression model predicted the incidence with an RMSE of 7.562 (SD 6.492). The most effective factors besides previous day incidence included the search frequency of handwashing, hand sanitizer, and antiseptic topics. The RMSE of the LSTM model was 27.187 (SD 20.705).

Conclusions

Data mining algorithms can be employed to predict trends of outbreaks. This prediction might support policymakers and health care managers to plan and allocate health care resources accordingly.
Peer-to-Peer Contact Tracing: Development of a Privacy-Preserving Smartphone App
Authors: Yasaka Tyler M , Lehrich Brandon M , Sahyouni Ronald
Published: April 2020

Background

The novel coronavirus disease 2019 (COVID-19) pandemic is an urgent public health crisis, with epidemiologic models predicting severe consequences, including high death rates, if the virus is permitted to run its course without any intervention or response. Contact tracing using smartphone technology is a powerful tool that may be employed to limit disease transmission during an epidemic or pandemic; yet, contact tracing apps present significant privacy concerns regarding the collection of personal data such as location.

Objective

The aim of this study is to develop an effective contact tracing smartphone app that respects user privacy by not collecting location information or other personal data.

Methods

We propose the use of an anonymized graph of interpersonal interactions to conduct a novel form of contact tracing and have developed a proof-of-concept smartphone app that implements this approach. Additionally, we developed a computer simulation model that demonstrates the impact of our proposal on epidemic or pandemic outbreak trajectories across multiple rates of adoption.

Results

Our proof-of-concept smartphone app allows users to create “checkpoints” for contact tracing, check their risk level based on their past interactions, and anonymously self-report a positive status to their peer network. Our simulation results suggest that higher adoption rates of such an app may result in a better controlled epidemic or pandemic outbreak.

Conclusions

Our proposed smartphone-based contact tracing method presents a novel solution that preserves privacy while demonstrating the potential to suppress an epidemic or pandemic outbreak. This app could potentially be applied to the current COVID-19 pandemic as well as other epidemics or pandemics in the future to achieve a middle ground between drastic isolation measures and unmitigated disease spread.
Assessment of Health Information About COVID-19 Prevention on the Internet: Infodemiological Study (Preprint)
Authors: Hernández-García Ignacio , Giménez-Júlvez Teresa
Published: April 2020

BACKGROUND

The internet is a large source of health information and has the capacity to influence its users. However, the information found on the internet often lacks scientific rigor, as anyone may upload content. This factor is a cause of great concern to scientific societies, governments, and users.

OBJECTIVE

The objective of our study was to investigate the information about the prevention of coronavirus disease 2019 (COVID-19) on the internet.

METHODS

On February 29, 2020, we performed a Google search with the terms “Prevention coronavirus,” “Prevention COVID-19,” “Prevención coronavirus,” and “Prevención COVID-19”. A univariate analysis was performed to study the association between the type of authorship, country of publication, and recommendations to avoid COVID-19 according to the World Health Organization (WHO).

RESULTS

In total, 80 weblinks were reviewed. Most of them were produced in the United States and Spain (n=58, 73%) by digital media sources and official public health organizations (n=60, 75%). The most mentioned WHO preventive measure was “wash your hands frequently” (n=65, 81%). A less frequent recommendation was to “stay home if you feel unwell” (n=26, 33%). The analysis by type of author (official public health organizations versus digital media) revealed significant differences regarding the recommendation to wear a mask when you are healthy only if caring for a person with suspected COVID-19 (odds ratio [OR] 4.39). According to the country of publication (Spain versus the United States), significant differences were detected regarding some recommendations such as “wash your hands frequently” (OR 9.82), “cover your mouth and nose with your bent elbow or tissue when you cough or sneeze” (OR 4.59), or “stay home if you feel unwell” (OR 0.31).

CONCLUSIONS

It is necessary to urge and promote the use of the websites of official public health organizations when seeking information on COVID-19 preventive measures on the internet. In this way, users will be able to obtain high-quality information more frequently, and such websites may improve their accessibility and positioning, given that search engines justify the positioning of links obtained in a search based on the frequency of access to them.
Research on the Effect of Individualized Therapy on Cognitive Function in Patients with Vascular Cognitive Impairment Based on Brain Rehabilitation Health Measurement System (Preprint)
Authors: Hu Yanqun , Zhong Wei , Cen Yunguang , Han Shuyan , Feng Zhiyun , Zhang Xuri , Li Wei , Wang Lanhua , Li Bin , Rogers Daniel
Published: April 2020

BACKGROUND

Background: Vascular cognitive disability (VCI) includes various degrees of mental decline related to cerebrovascular disease. It refers to the basic pathological process of the formation of Alzheimer's disease. Its early diagnosis and treatment are beneficial to improve the prognosis of patients.

OBJECTIVE

Objective: To explore the effect of individualized therapy based on brain rehabilitation health measurement system on the cognitive function and event-related potential (ERP) P300 of patients with vascular cognitive impairment no dementia (VCIND).

METHODS

Methods: Sixty patients with non-dementia vascular cognitive impairment were randomly divided into a training group and a control group. Both groups were given conventional medication and traditional rehabilitation training. Based on it, the training group added cognitive training of the brain rehabilitation health measurement system, 40 minutes/time, once a day, 5 times a week for 4 weeks. Then, the mini-mental state examination (MMSE), Montreal cognitive assessment (MoCA), Barthel Index (BI) and myoelectric evoked potential were used to measure and evaluate the cognitive function, daily life activities and P300 of the two groups of patients.

RESULTS

Results: After treatment, the MoCA score, MMSE, BI score, visual space and executive function, attention, language function, and delayed memory of the training group were significantly improved compared with the control group, and the difference was significant (P <0.05). The incubation period of P300 in the training group was shorter than that in the control group, and the amplitude was higher than that in the control group, the difference was statistically significant (P <0.05).

CONCLUSIONS

Conclusions: Brain rehabilitation health measurement system assisted cognitive training can effectively improve the cognitive function and daily activities of VCIND patients.

CLINICALTRIAL
The role of iron oxidizing bacteria to the quality of leachate on acid sulphate soil
Authors: Napisah Khairatun , Maas Azwar , Hidayah Utami Sri Nuryani , Yusuf Wahida Annisa
Published: April 2020

The problem encountered in acid sulphate soil is the presence of pyrite (FeS2) which causes soil  to have highly acid reaction when the pyrite is oxidized. The decline in quality not only occurs on the soil  but also on the quality of the surrounding waters. One way to improve the quality of the leachate is by draining it through biofilter plants in the form of purun tikus (Eleocharis dulcis) and bulu babi (Eleocharis retroflaxa) which can absorb or neutralize these elements. The purpose of this research was to know the inoculant influence of iron oxidizing bacteria to leachate quality in acid sulphate soil. The research was conducted on a pot scale in greenhouse. The research was in randomized block design (RBD) of 3-factors with 3 replications. The first factor was inoculants, the second factor was water management, and the third one was phytoremediation material (Eleocharis dulcis  and Eleocharis retroflaxa). The results showed that the plant height in the inoculant treatment+wood charcoal was in the range of 89.33−95.33 cm, while that in the inoculant treatment+husk charcoal was in the range of 89.50­­­−93.00 cm. Meanwhile, the yield of rice with bacteria oxidizing iron inoculant+wood charcoal was higher, which was at 6.77 ton.ha-1 than inoculant treatment of oxidizing iron+husk charcoal which was only 5.95 ton.ha-1.
Histochemistry of backcross 1 of oil palm seeds at different storage periods
Authors: Ernayunita Ernayunita , Taryono Taryono , Yudono Prapto
Published: April 2020

Oil palm backcross 1 is the result of the crossing between E. oleifera and E. guineensis, followed by backcrossing to one of its parents. It has several advantages, including slow height growth and good oil quality, thereby having the potential to be developed. However, it also has a short seed shelf life, which might be inherited from E. oleifera that has relatively quick seed deterioration. This is problem to the breeding program, and there have not been many studies on the seed deterioration process. A histological examination can determine the composition of food reserves in seed endosperm tissue. Therefore, it is necessary to assess the histochemistry of seeds concerning the process of seed deterioration. Histochemical tests with Sudan III, Milon, and IKI reagents were used as histochemical tests of fat, protein and carbohydrate seed content with different seed storage periods, i.e. 4, 3, 2, and less than 1 year. The result showed that the fat content decreased during the storage periods. Based on carbohydrates and proteins staining, there were only very few substances , which were difficult to distinguish among the storage periods, so that this analysis could not be used as the determining indicator of seed deterioration. The fat content was a determining factor of seed deterioration and quality. The oil palm seed storage up to 3-4 years led to the reduction in the fat content in significant quantities compared to the fresh seeds stored less than 1 year as they still contained a lot of fat in the cell.
ANTIOXIDANT AND HEPATOPROTECTIVE EFFECT OF QUERCUS ILEX LEAVES EXTRACT IN ETHANOL INDUCED LIVER DAMAGE IN WISTAR RATS
Authors: MALIK RENU , SINGHAL K. G.
Published: April 2020

Objective: This study was undertaken to investigate the hepatoprotective and antioxidant activity of Quercus ilex leaves extract (QILE) on ethanol-induced toxicity in Wistar rats.

Methods: Hepatotoxicity was induced by administering ethanol (40%) at a dose of 7.9 gm/kg/day; p. o. (1:1 of ethanol in olive oil) for 28 d. Silymarin 100 mg/kg/day; p. o. was used as a standard drug. The whole study was divided into a prophylactic and curative study. In the prophylactic study, the Silymarin and QILE (test drug) 100, 200, and 400 mg/kg Body Weight(BW) given orally one hour before administration of 40% ethanol administration for 28 d. In the curative study, 7 d of treatment of Silymarin and QILE 200 and 400 mg/kg BW was given orally after 28 d of ethanol administration to different groups.

Results: Hepatoprotectivity was confirmed by the highly significantly (p<0.001) restoration of elevated biochemical parameters like SGPT, SGOT, ALP, TB, and highly significantly (p<0.001) depleted Albumin and Total protein levels by 200 mg/kg BW QILE in comparison to the positive control group. QILE 200 mg/kg highly significantly (p<0.001) raised the antioxidants by draining the elevated oxidative stress markers in comparison of positive control group. At dose levels QILE 200 mg/kg, significant (p<0.05) protection from loss in body weight and in liver weight was found when the comparison was done with the positive control group. Histopathology revealed that QILE 200 mg/kg reduced the markers of cell necrosis.

Conclusion: Present study revealed that Quercus ilex leaves have antioxidant and hepatoprotective activity due to its chemical constituents.
Teoria crítica, hermenêutica e formação de professores: contribuições de Mario Osorio Marques
Authors: Kuhn Martin , Callai Helena Copetti
Published: April 2020

Diferentes racionalidades têm perpassado a formação de professores. Expressivamente, em nosso contexto, a tradição acadêmica e a epistemologia da prática. Acusadas de acalentarem a distinção entre teoria e prática assumem um caráter instrumentalizador da formação de professores.  Sustentamos que o diálogo proposto por Mario Osorio Marques, teoria crítica e a hermenêutica, se constitui em possibilidade razoável de compreender a educação e a formação dos educadores em tempos que a racionalidade instrumental se agudiza. Marques sugere três exigências à formação dos educadores: a exigência hermenêutica, a exigência crítico-dialética e a exigência epistêmico-instrumental.