bluuebunny/crossref_metadata_2025 huggingface dataset:
Correlação entre Trihalometanos e o Desenvolvimento do Câncer de Bexiga
Authors: Affornalli Beatriz de Almeida , Macetti Nadinne Maria , Marques Camila Moraes , Andrade Diancarlos Pereira de , Mello Rosiane Guetter
Published: December 2021

Introdução: Os trihalometanos (THM) constituem um grupo de subprodutos gerados pela desinfecção da água por meio da cloração. Desde a primeira vez em que foram reportados, em 1974, são alvos de estudos que buscam estabelecer uma relação positiva entre a exposição dos humanos a esses compostos e o desenvolvimento de câncer. Objetivo: Revisão da literatura cientifica disponível sobre a presença de THM na água e sua relação com o desenvolvimento do câncer de bexiga. Método: Levantamento bibliográfico da revisão feito nas bases de dados ScienceDirect e PubMeb. Os descritores utilizados foram ‘‘trihalomethane’’, ‘‘disinfection by-products’’ e ‘‘bladder cancer’’ dos Descritores em Ciências da Saúde (DeCS) da Biblioteca Virtual em Saúde. Os artigos selecionados foram publicados nos últimos cinco anos. Resultados: A amostra final desta revisão foi constituída por 31 artigos, sendo a maioria deles publicados em jornais e revistas sobre meio ambiente. Analisaram-se estudos descritivos, metanálises e outros estudos individuais com delineamento experimental, encontrando uma associação positiva, mas controversa, entre os THM e o câncer, associada a diferentes mecanismos. A relação mais consistente tem sido entre a exposição crônica e o câncer de bexiga. Conclusão: Os estudos reconhecem que existem riscos significativos a saúde relacionados aos THM, no entanto, evidencias que esclareçam os mecanismos de ação e o papel que outros fatores de risco possuem, juntamente com os THM, ainda permanecem incertas.
RESPON TANAMAN CABAI MERAH (Capsicum annum L.) TERHADAP KOMPOSISI DAN DOSIS BOKASHI PELEPAH SAWIT DAN DAUN REMUNGGAI
Authors: Kinasih Nur Illha Wahyu , Nurseha Nurseha , Pertiwi Nurlianti
Published: December 2021

This experiment aims to determine the response of red chili (Capsicum annum L.) plants to the composition and dosage of bokashi oil palm and remunggai (Moringa oleifera). This research was conducted from January to April 2021, in Kayu Arang Village, Sukaraja District, Seluma Regency. The design used was a Factorial Completely Randomized Desing (CRD). The first factor is the composition (A) namely: A1: remunggai + palm frond (1:1), A2: remunggai + palm frond (1:3), A3: remunggai + paln frond (1:5) and the second factor is bokashi dose (B) namely: B0 : 1 ton/ha bokashi + NPK recommendation, B1 : 10 ton/ha bokashi, B2 : 20 ton/ha bokashi, B3 : 30 ton/ha bokashi, B4 : 40 ton/ha bokashi. The treatment was repeated 3 times to produce 45 experimental units. The result of the analysis of variance was continued with Duncan’s Multiple Range Test (DMRT) with a test level of 5%. The results showed that giving bokashi composition had on significant effect on all observed variables. Meanwhile, in giving bokashi dose, there were observational variables that had a significant effect, namely plant height, number of productive branches, the total number of fruit per plant, fruit weight per plant, the weight of dry stover stove, and the parameters of variables that had no significant effect were flowering age and age harvest.
A pesquisa-ação e as suas contribuições para a ciência metodológica: aspectos gerais
Authors: Dendasck Carla Viana
Published: December 2021

Em virtude do aumento da popularidade e possibilidade de uso da pesquisa-ação, o instrumento passou a ser utilizado de maneira significativa, porém, com conceito ainda não consolidado, o termo tem sido aplicado de maneira abstrata, sem interpretações profundas e detalhadas quanto ao uso em diversos contextos. Pretende-se esclarecer ao longo deste artigo o significado do termo, e, como este tipo de instrumento pode ser aplicado da melhor forma, atuando dentro da esfera do rigor científico-metodológico. Tem-se como problema de pesquisa: quais as possibilidades de uso da pesquisa-ação, suas etapas e cuidados fundamentais? A relevância da ferramenta reside no fato de que permite a realização de uma pesquisa de maneira sistematizada, contínua e empiricamente embasada. Assim, discutir-se-á sobre o papel da teoria na pesquisa-ação e apontar-se-á as características inerentes às suas fases fundamentais. Algumas questões comuns relativas ao método, como, por exemplo, a participação do pesquisador, a função social da reflexão, a necessidade de gerir o conhecimento adquirido e a ética em pesquisa dever-se-ão ser consideradas. Apresenta-se, por fim, alguns “modelos” de pesquisa-ação que podem contribuir com os pesquisadores na escolha e organização metodológicas.
Todos os nomes: identidade, pobo, país
Authors:   Real Academia Galega, Boullón Agrelo Ana Isabel
Published: December 2021

Discurso lido no acto da súa recepción pola ilustrísima señora dona Ana Isabel Boullón Agrelo e resposta do excelentísimo señor don Ramón Lorenzo Vázquez. O solemne acto académico en que foron lidos os dous discursos recolleitos no presente volume celebrouse o 11 de decembro de 2021 no Teatro Cine Elma, na Pobra do Caramiñal.
Recent Advances in the Synthesis of Isocoumarins and Polyaromatic Hydrocarbons for Photoactive Materials
Authors:   Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, ul. Vavilova 28, Moscow, 119991 Russia, Arsenov M. A. , Loginov D. A. ,   Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, ul. Vavilova 28, Moscow, 119991 Russia
Published: December 2021

The discovery of transition metal-catalyzed selective activation of aromatic carbon–hydrogen bonds in 1993 has opened a new era in the synthesis of carbo- and heterocyclic compounds. This review covers the applications of oxidative annulations of aromatic compounds with alkynes involving CH activation for the synthesis of isocoumarins and polyaromatic hydrocarbons (PAHs). The limitations, advantages, and mechanical aspects of this approach as well as the current tendencies in the application of the reaction products for photoactive materials are discussed.
Deworming the Grinder for Successful Extrication of a Mangled Hand: A Case Report and Review of Literature
Authors: Md Yusoff Zuhri , Harun Mohd Hezery , Ab Halim Ashraf Hakim , Mohamed Ramlee Fadzrul Abbas , Lim Teck Siang
Published: December 2021

Grinding machine injuries are known to cause severe mutilating injuries of the upper limb. In some cases, the machinery equipment may still be attached to the limb when the patient reaches the hospital. In treating these injuries, the patient’s hemodynamic status should be the first priority of resuscitation. Following this and whenever possible, a reversal of the grinding mechanism should be done to free the limb as this would allow assessment of the extent of zone-of-injury prior to starting the surgical procedure. We report a case of a 28-year-old male who sustained a mangled hand injury that was successfully extricated from an industrial grinding machine, thereby allowing preservation of precious length of the limb during surgery. This case highlights the importance of adhering to safety precautions at the workplace to reduce the risk of potential occupational hazards when dealing with machinery equipment.
Gebeliğin ilk trimesterindeki ineklerde embriyonik ve fötal kayıplar
Authors: CENGİZ Mehmet , TOHUMCU Vefa
Published: December 2021

Embriyonik ve fötal ölümler süt sığırcılığı işletmelerinde hem ekonomik hem de biyolojik verimliliği olumsuz etkileyen kritik problemlerdir. Gebeliğin ilk trimesterindeki gebelik kayıpları, sonraki dönemlerdeki gebelik kayıplarına göre daha sık gözlenir. Her tohumlamada, oositlerin neredeyse tamamı fertilize olurken, oluşan embriyoların yaklaşık yarısı doğuma ulaşabilmektedir. İlk trimesterdeki gebelik kayıplarının çoğunluğu (%60 – 87) tohumlama sonrası ilk 28 günde meydana gelirken (erken embriyonik ölüm), ilerleyen günlerde de (28 – 90. günler) (%10 – 35) geç embriyonik veya erken fötal ölümler gözlenmektedir. Her ne kadar erken embriyonik ölümlerin prevalansı daha fazla olsa da, geç embriyonik ve erken fötal ölümler daha yüksek ekonomik zarara neden olmaktadır. Doğum sonrası jinekolojik problemler, uterus içi ve uterus dışı enfeksiyonlar, doğum sonrası erken dönemde yapılan tohumlamalar, tohumlama sayısı, kan progesteron düzeyi, genetik nedenler, ikiz gebelik, ırk ve süt verimi, mevsim ve vücut kondüsyon skoru gebelik kayıplarının en önemli nedenleridir. Gebelik kayıplarının tespitinde, rektal palpasyon, progesteron ölçümleri (P4), ultrasonografi ve gebelik ilişkili glikoprotein (PAG) ölçümleri kullanılmaktadır. İlk trimesterde meydana gelen gebelik kayıplarının önlenmesi amacıyla tohumlama sonrası GnRH (gonadotropin salıcı hormon) ve hCG (insan koriyonikgonadotropini) enjeksiyonu ile vajina içi progesteron salan gereçlerin kullanımı önerilmektedir.
Partial Pedicle Subtraction Osteotomy for Patients with Thoracolumbar Fractures : Comparative Study between Burst Fracture and Posttraumatic Kyphosis
Authors: Choi Ho Yong , Jo Dae Jean
Published: December 2021

Objective : To evaluate the surgical outcomes of partial pedicle subtraction osteotomy (PPSO) in patients with thoracolumbar fractures and compare the outcomes of PPSO for burst fractures with those for posttraumatic kyphosis (PTK).Methods : From June 2013 to May 2019, 20 consecutive adult patients underwent PPSO for thoracolumbar fractures at the levels of T10 to L2. Of these patients, 10 underwent surgery for acute fractures (burst fractures), and 10 for sequelae of thoracolumbar fractures (PTK). Outcomes of PPSO were evaluated and compared between the groups.Results : Twenty patients (each 10 patients of burst fractures and PTK) with a mean age of 64.7±11.1 years were included. The mean follow-up period was 21.8±11.0 months. The mean correction of the thoracolumbar angle was -34.9°±18.1° (from 37.8°±20.5°preoperatively to 2.8°±15.2° postoperatively). The mean angular correction at the PPSO site was -38.4°±13.6° (from 35.5°±13.6° preoperatively to -2.9°±14.1° postoperatively). The mean preoperative sagittal vertical axis was 93.5±6.7 cm, which was improved to 37.6±35.0 cm postoperatively. The mean preoperative kyphotic angle at the PPSO site was significant greater in patients with PTK (44.8°±7.2°) than in patients with burst fractures (26.2°±12.2°, p=0.00). However, the mean postoperative PPSO angle did not differ between the two groups (-5.9°±15.7° in patients with burst fractures and 0.2°±12.4° in those with PTK, p=0.28). The mean angular correction at the PPSO site was significantly greater in patients with PTK (-44.6°±10.7°) than in those with burst fractures (-32.1°±13.7°, p=0.04). The mean operation time was 188.1±37.6 minutes, and the mean amount of surgical bleeding was 1030.0±533.2 mL. There were seven cases of perioperative complications occurred in five patients (25%), including one case (5%) of neurological deficit. The operation time, surgical bleeding, and complication rates did not differ between groups.Conclusion : In cases of burst fracture, PPSO provided enough spinal cord decompression without corpectomy and produced sagittal correction superior to that achieved with corpectomy. In case of PTK, PPSO achieved satisfactory curve correction comparable to that achieved with conventional PSO, with less surgical time, less blood loss, and lower complication rates. PPSO could be a viable surgical option for both burst fractures and PTK.
Do Obliquity and Position of the Oblique Lumbar Interbody Fusion Cage Influence the Degree of Indirect Decompression of Foraminal Stenosis?
Authors: Mahatthanatrakul Akaworn , Kotheeranurak Vit , Lin Guang-Xun , Hur Jung-Woo , Chung Ho-Jung , Lokanath Yadhu K , Pakdeenit Boonserm , Kim Jin-Sung
Published: December 2021

Objective : Oblique lumbar interbody fusion (OLIF) is a surgical technique that utilizes a large interbody cage to indirectly decompress neural elements. The position of the cage relative to the vertebral body could affect the degree of foraminal decompression. Previous studies determined the position of the cage using plain radiographs, with conflicting results regarding the influence of the position of the cage to the degree of neural foramen decompression. Because of the cage obliquity, computed tomography (CT) has better accuracy than plain radiograph for the measurement of the obliquely inserted cage. The objective of this study is to find the correlation between the position of the OLIF cage with the degree of indirect decompression of foraminal stenosis using CT and magnetic resonance imaging (MRI).Methods : We review imaging of 46 patients who underwent OLIF from L2-L5 for 68 levels. Segmental lordosis (SL) was measured in a plain radiograph. The positions of the cage were measured in CT. Spinal canal cross-sectional area (SCSA), and foraminal crosssectional area (FSCA) measurements using MRI were taken into consideration.Results : Patients’ mean age was 69.7 years. SL increases 3.0±5.1 degrees. Significant increases in SCSA (33.3%), FCSA (43.7% on the left and 45.0% on the right foramen) were found (p<0.001). Multiple linear regression analysis shows putting the cage in the more posterior position correlated with more increase of FSCA and decreases SL correction. The position of the cage does not affect the degree of the central spinal canal decompression. Obliquity of the cage does not result in different degrees of foraminal decompression between right and left side neural foramen.Conclusion : Cage position near the posterior part of the vertebral body increases the decompression effect of the neural foramen while putting the cage in the more anterior position correlated with increases SL.
Clinical Implications of the Mitotic Index as a Predictive Factor for Malignant Transformation of Atypical Meningiomas
Authors: Kwon Sae Min , Kim Jeong Hoon , Kim Young-Hoon , Hong Seok Ho , Cho Young Hyun , Kim Chang Jin , Nam Soo Jeong
Published: December 2021

Objective : Intracranial atypical meningiomas have a poor prognosis and high rates of recurrence. Moreover, up to one-third of the recurrences undergo high-grade transformation into malignant meningiomas. We aimed to investigate the clinical factors that can predict the propensity of malignant transformation from atypical to anaplastic meningiomas.Methods : Between 2001 and 2018, all patients with atypical meningioma, in whom the tumors had undergone malignant transformation to anaplastic meningioma, were included. The patients’ medical records documenting the diagnosis of atypical meningioma prior to malignant transformation were reviewed to identify the predictors of transformation. The control group comprised 56 patients with atypical meningiomas who were first diagnosed between January 2017 and December 2018 and had no malignant transformation.Results : Nine patients in whom the atypical meningiomas underwent malignant transformation were included. The median time interval from diagnosis of atypical meningioma to malignant transformation was 19 months (range, 7–78). The study group showed a significant difference in heterogeneous enhancement (77.8% vs. 33.9%), bone invasion (55.6% vs. 12.5%), mitotic index (MI; 14.8±4.9 vs. 3.5±3.9), and Ki-67 index (20.7±13.9 vs. 9.5±7.1) compared with the control group. In multivariate analysis, increased MI (odds ratio, 1.436; 95% confidence interval, 1.127–1.900; p=0.004) was the only significant factor for predicting malignant transformation.Conclusion : An increased MI within atypical meningiomas might be used as a predictor of malignant transformation. Tumors at high risk for malignant transformation might require more attentive surveillance and management than other atypical meningiomas.
Methyl-mercaptane adsorption and sensing on Fe-/Co-graphene structures: A DFT study
Authors: YUKSEL Numan , KOSE Ahmet , FELLAH Mehmet Ferdi
Published: December 2021

In this research, the adsorption and detection abilities of Fe and Co doped graphene structures for methyl-mercaptan molecule were investigated by Density Functional Theory (DFT) method. B3LYP hybrid functional and LANL2DZ/6-31G(d,p) basis sets were used in the calculations. At the end of the adsorption processes, Fe and Co doped graphene structures were determined to be suitable adsorbents for the methyl-mercaptan molecule. In addition, charge transfer happened from the methyl-mercaptan molecule to the Fe and Co-doped graphene structures. The electronic sensor and the Φ-type sensor properties were also investigated and it was determined that Fe-graphene structure could be only used as an electronic sensor for methyl-mercaptan molecule at room temperature.
Beetroot and radish production under different doses of green manures
Authors: Lino Vitor Abel da Silva , Bezerra Neto Francisco , Lima Jailma Suerda Silva de , Santos Elizangela Cabral dos , Nunes Renato Leandro da Costa , Guerra Natan Medeiros , Lino Francisca Karla Kelly da Silva , Sá Jolinda Mércia de , Desravines Rose Paula , Chaves Aridênia Peixoto , Porto Vania Christina do Nascimento
Published: December 2021

Green manuring with spontaneous species from Caatinga biome has become an important strategy in production vegetables. One of the great challenges in tuberous vegetables production is to define an optimized quantity that provides a high productive yield with economic efficiency of production system. The objective of this study was to optimize agronomically and economically the production and its components of tuberous crops of beetroot and radish when manured with different amounts of green manures biomass, Merremia aegyptia and Calotropis procera from Caatinga biome, in two cropping seasons. The experimental design was a randomized complete block with five treatments and five replications. Treatments consisted of green manures amounts (16, 26, 36, 46, 56 t ha-1). The maximum agronomic efficiency of beetroot and radish was obtained with incorporation of 49.87 and 39.43 t ha-1 of M. aegyptia and C. procera, respectively, and the production maximum economic efficiency was reached when 36.14 and 36.48 t ha-1, respectively, of biomass of these green manures were added to the soil. The returns rate obtained in beetroot and radish cultivation using the manures optimized amounts were 1.42 and 1.32 reais obtained for each real invested in the production of these tuberous.
qNMR quantification and in silico analysis of isobrucein B and neosergeolide from Picrolemma sprucei as potential inhibitors of SARS-CoV-2 protease (3CLpro) and RNA-dependent RNA polymerase (RdRp) and pharmacokinetic and toxicological properties
Authors: Silva Marcos Túlio da , Oliveira Matheus Gabriel de , Paula José Realino de , Silva Vinicius Barreto da , Neves Kidney de Oliveira Gomes , Machado Marcos Batista , Nunomura Rita de Cássia Saraiva
Published: December 2021

Objective: To quantify the quassinoids of P. sprucei, a medicinal plant that is native to the Amazon region, using qNMR and investigate the inhibitory potential of isobrucein B and neosergeolide on the 3CLpro and RdRp targets of SARS-CoV-2 through in silico approaches. Methods: the quantification was performed in a fraction (F2-F3) enriched with the quassinoids isobrucein B and neosergeolide using the PULCON method. In silico assays were performed using molecular docking to assess interactions and binding affinity between neosergeolide and isobrucein B ligands with SARS-CoV-2 3CLpro and RdRp targets, and online servers were used to estimate pharmacokinetic and toxicity. Results: It was possible to determine the quantity of the two quassinoids isobrucein B and neosergeolide in the F2-F3 fraction (769.6 mg), which were present in significant amounts in the PsMeOH extract (5.46%). The results of the docking analysis, based on the crystallized structures of RdRp and 3CLpro, indicated that isobrucein B and neosergeolide are potential inhibitors of the two proteins evaluated, as well as showing the importance of hydrogen bonding and pi (π) interactions for the active sites foreseen for each target. Conclusion: The results suggest that P. sprucei quassinoids may interact with 3CLpro and RdRp targets. In vitro and in vivo experiments are needed to confirm the results of molecular docking and investigate the risks of using P. sprucei as a medicinal plant against COVID-19.
Incidência de traumas faciais em atletas profissionais: revisão integrativa
Authors: Lima Ernandi Ribeiro Cezar de , Nascimento Estéfane Carvalho do , Sousa Gabriela de Almeida , Santos Nathalia , Lessa Filho Luciano Schwartz
Published: December 2021

A incidência de traumas faciais vem crescendo ao redor do mundo por diversos fatores, dentre eles a prática esportiva. Lesões faciais podem ter consequências catastróficas para os atletas, sendo assim, é de extrema importância examinar as taxas, os fatores de risco e a natureza desses traumas. O objetivo deste presente estudo foi realizar uma investigação da incidência de traumas faciais, tais como as regiões anatômicas mais acometidas e tratamento através de uma revisão integrativa da literatura. Foi realizada uma revisão integrativa, por meio de pesquisas nas bases de dados SCIELO, PUBMED e MEDLINE, utilizando o operador boleano AND, sendo critérios de inclusão, artigos em inglês que falem sobre a incidência de traumas faciais em atletas, de categoria profissional, bem como as regiões anatômicas envolvidas, o esporte e o uso ou não de proteção facial e bucal. Á realização dos levantamentos bibliográficos ocorreu no mês de março de 2020. Analisaram-se 12 artigos que atenderam os critérios de inclusão. Os artigos revisados mostraram que o esporte que mais ocorre traumas faciais é o futebol, a região anatômica mais acometida foi o complexo zigomático, e a não utilização de medidas preventivas foi o principal fator para ocorrência dos traumas. Esta revisão revelou uma alta prevalência de lesões maxilofaciais, com prevalência maior na região da mandíbula e complexo zigomático.
Estimulação elétrica neuromuscular na força muscular e no desempenho motor de idosos: uma revisão sistemática
Authors: Figueira Mariana Correia , Ferreira Ana Clara Nunes Oliveira , Sampaio Lucas Silveira
Published: December 2021

Este estudo teve o objetivo de avaliar a literatura científica de forma sistemática para analisar o efeito da EENM no ganho de força muscular e no desempenho motor em idosos. O levantamento bibliográfico foi realizado através de publicações indexadas na base de dados da Biblioteca Virtual de Saúde, Scientific Electronic Library Online, Medical Literature Analysis and Retrieval System Online, US National Library of Medicine National Institutes of Heath e Physiotherapy evidence database. A busca foi realizada utilizando os descritores na língua portuguesa e inglesa: “Terapia por estimulação elétrica”, “Força muscular”, “Desempenho Motor”, “Idoso”.  Para organização do estudo, foram seguidos os critérios da revisão sistemática PRISMA (Principais Itens para Relatar Revisões Sistemáticas e Metanálises). Após avaliação, foram selecionados cinco artigos que se enquadravam nos critérios de inclusão. Diversos estudos mostraram dados que fornecem evidências de que a eletroestimulação neuromuscular é um método seguro para combater o declínio muscular em idosos, como também evita a perda da força muscular e proporciona seu incremento. Esta revisão foi conclusiva no tocante à eficácia da EENM, pois demonstrou que há efetivamente aumento da força de MMII e melhora no desempenho motor após um protocolo de EENM em idosos, mesmo com grande divergência nos parâmetros e no tempo de intervenção.
Tecnologias digitais da informação e comunicação no contexto educação física escolar: análises sobre as abordagens Instrucionistas e Construcionistas
Authors: Faria João Paulo de Oliveira , Gomes Geórgia Regina Rodrigues , Nascimento Matheus Carvalho do
Published: December 2021

As Tecnologias Digitais da Informação e Comunicação (TDIC’s) tem influenciado significativamente a maneira como a escola tem construído as suas práticas pedagógicas. Em especial neste cenário, o Componente Curricular denominado “Educação Física” pôde reorganizar e fomentar novas formas de trabalhar as práticas corporais no contexto educacional. Este trabalho descreve as contribuições de uma proposta em que a tecnologia é pensada como dispositivo didático nas escolas, com o objetivo de propor reflexões sobre as diferentes possibilidades que as (TIDC’s) oferecem para as aulas de Educação Física (EFI) no Ensino Médio. Tratou-se de estudo de caso, em que 35 Estudantes de um Curso de Licenciatura em EFI construíram e analisaram sequências didáticas permeadas por diferentes formas de utilização das tecnologias educacionais pautadas nas abordagens instrucionistas e construcionistas da informática na educação. O estudo esclarece que os métodos instrucionistas na EFI reforçam o caráter tecnicista, mecanicista e técnico do movimento humano, enquanto os métodos construcionistas direcionam-se para aulas com metodologias ativas e mais significativas. Nesta segunda abordagem o professor ganha status de mediador do conhecimento abrindo possibilidade para a construção de práticas pedagógicas mais autônomas e colaborativas. Por fim, esclarece que as 06 (seis) unidades temáticas apresentadas pela Base Nacional Comum Curricular (BNCC) poderão se beneficiar com perspectivas pedagógicas mais críticas e multiculturalistas no contexto da EFI nas escolas.
A osteonecrose dos maxilares induzida por bifosfonatos: uma revisão de literatura
Authors: Dorigan Maria Caroline , Matias Juliano Bernardes , Tognetti Valdinéia Maria , Torres Silvia Cristina Mazeti
Published: December 2021

Os bifosfonatos atuam no processo de remodelação óssea, impedindo a reabsorção patológica ocasionada por determinadas doenças como a osteoporose, osteogênese imperfeita, doença de Paget e neoplasias com metástases ósseas. O bifosfonato incorpora na matriz óssea devido a sua alta afinidade com os ossos, caracterizando seu efeito cumulativo e proporcionando o risco de desenvolvimento da osteonecrose dos maxilares induzida por bifosfonatos, que discorre de uma complicação decorrente do uso desses fármacos onde existe a exposição óssea necrótica patológica de ossos maxilares podendo ser de surgimento espontâneo ou induzida por intervenções odontológicas. O objetivo deste estudo visa a compreensão da osteonecrose e sua etiologia afim de identificar fatores de risco locais ou sistêmicos, métodos de prevenção, evidenciar meios de diagnóstico através de sinais e sintomas clínicos e exames complementares além da realização do seu estadiamento em caso de ocorrência e os respectivos tratamentos existentes. Para a construção da revisão de literatura alguns passos foram determinantes como a elaboração de questões norteadoras e hipóteses, pesquisa bibliográfica para coleta de dados seguindo critérios de inclusão e exclusão através de análise minuciosa e interpretação de resultados.  Com o envelhecimento populacional o número de pessoas usando medicações antirreabsortivas aumentou significativamente e com isso, o risco de desenvolvimento de complicações como a abordada também cresceu. Conclui-se que é de extrema importância o papel do cirurgião-dentista em uma equipe multidisciplinar para tratamento destes indivíduos que fazem uso deste tipo de fármaco afim de evitar e diminuir a ocorrência da osteonecrose garantindo assistência, saúde e bem-estar ao paciente.
As perspectivas da felicidade na era digital: o caso brasileiro
Authors: Almeida Neto Honor de , Santos Everton Rodrigo , Castro Henrique Carlos de Oliveira , Moura José Antônio Ribeiro de
Published: December 2021

Este artigo tem como objetivo principal investigar o impacto das novas tecnologias de informação e comunicação nas relações humanas e sociais, no que tange ao sentimento de felicidade e de bem-estar subjetivo. Em outras palavras, procuramos demonstrar, como hipótese de trabalho, que há uma relação estreita entre as novas mediações sociais e a instauração de uma cultura mais autônoma e, portanto, de bem-estar, que está na gênese da Sociedade em Rede nesta Era Digital. Redes sociais constituem-se em uma plataforma digital que possibilita e potencializa a autocomunicação de massas, a sociabilidade, cuja prática tende a instaurar uma cultura ligada à autonomia e ao empoderamento, criando o processo de individuação. Os dados analisados de nossa pesquisa apontam que pessoas mais conectadas na rede tendem a ser mais felizes, nutrindo um sentimento de maior liberdade e autonomia. A base empírica deste artigo é a Sétima Onda da Pesquisa Mundial de Valores (WVS, 2017-2020), pesquisa quantitativa, tipo survey, que utilizaremos para demonstrar nosso argumento.
A contribuição dos Institutos Federais para o desenvolvimento local: Uma análise comparativa para municípios do estado de Minas Gerais, Brasil
Authors: Felizardo Júnior Nuno Álvares , Ferreira Marco Aurélio Marques , Gava Rodrigo
Published: December 2021

Uma política pública brasileira de educação voltada para o fomento do desenvolvimento local são os Institutos Federais de Educação, Ciência e Tecnologia (IF’s), que apresentam uma organização descentralizada e localizada em diversos municípios, inclusive, com população abaixo de 10.000 habitantes. Essa estrutura descentralizada – multicampi - e a clara definição do escopo geográfico dos IF’s enfatizaram o compromisso de intervir em suas respectivas localidades e regiões, por meio da criação de soluções técnicas e tecnológicas que levem ao desenvolvimento sustentável com inclusão social. Portanto, entender se os Institutos Federais afetam positivamente o desenvolvimento econômico local permite convergir esforços para melhorar esse relacionamento. Isso permite a elaboração da seguinte questão: O estabelecimento de Institutos Federais influencia o desenvolvimento local? A fim de responder a essa questão, foi realizado um clusterização dos municípios por meio de indicadores de desenvolvimento coletados no ano de 2008 e, posteriormente, uma análise qualitativa entre duas cidades, por meio de indicadores coletados no ano de 2016, sede e não sede de Institutos Federais. O resultado sugere que a influência dos Institutos Federais pode ser observada com mais destaque em municípios de menor concentração populacional, bem como, com mais ênfase nos indicadores de educação e, em seguida, trabalho e renda.
Brucella ceti sequence type 23, 26, and 27 infections in North American cetaceans
Authors: Curtiss JB , Colegrove KM , Dianis A , Kinsel MJ , Ahmed N , Fauquier D , Rowles T , Niemeyer M , Rotstein DS , Maddox CW , Terio KA
Published: December 2021

Brucella ceti infection is associated with a variety of disease outcomes in cetaceans globally. Multiple genotypes of B. ceti have been identified. This retrospective aimed to determine if specific lesions were associated with different B. ceti DNA sequence types (STs). Characterization of ST was performed on 163 samples from 88 free-ranging cetaceans, including common bottlenose dolphin Tursiops truncatus (T.t.; n = 73), common short-beaked dolphin Delphinus delphis (D.d.; n = 7), striped dolphin Stenella coeruleoalba (n = 3), Pacific white-sided dolphin Lagenorhynchus obliquidens (n = 2), sperm whale Physeter macrocephalus (n = 2), and harbour porpoise Phocoena phocoena (n = 1), that stranded along the coast of the US mainland and Hawaii. ST was determined using a previously described insertion sequence 711 quantitative PCR. Concordance with 9-locus multi-locus sequence typing was assessed in a subset of samples (n = 18). ST 26 was most commonly identified in adult dolphins along the US east coast with non-suppurative meningoencephalitis (p = 0.009). Animals infected with ST 27 were predominately perinates that were aborted or died shortly after birth with evidence of in utero pneumonia (p = 0.035). Reproductive tract inflammation and meningoencephalitis were also observed in adult T.t. and D.d. with ST 27, though low sample size limited interpretation. ST 23 infections can cause disease in cetacean families other than porpoises (Phocoenidae), including neurobrucellosis in D.d. In total, 11 animals were potentially infected with multiple STs. These data indicate differences in pathogenesis among B. ceti STs in free-ranging cetaceans, and infection with multiple STs is possible.
Utility of Perioperative Warming for the Prevention of Surgical Site Infection and Patient Rehabilitative Complications: A Systematic Review
Authors: Shang Aaron C. , Galow Kristen E. , Essuman Jeffrey T.
Published: December 2021

Overview: Surgical site infection (SSI) is a leading cause of postoperative complication, rehospitalisation, and patient mortality after invasive clinical interventions. Surgical risks compounded by SSI introduce greater medical, economic, and quality-of-life challenges for both patients and providers alike, and to better inform clinical practice, empirical evaluation of modern surgical warming techniques is relevant. This systematic review and meta-analysis qualitatively examined the efficacy of both active and passive perioperative warming interventions upon SSI presentation versus standardised (i.e., non-warming) care.

Methods: This review analysed available literature on active and passive warming application across general anaesthesia procedures, containing longitudinal data on patient outcomes and SSI. The primary outcome studied was occurrence of post-surgical SSI; secondary outcomes included rehabilitative length of stay, attributable SSI-related mortality, and incidence of re-admittance.

Results: Meta-analysis demonstrated a significantly reduced risk ratio for SSI in patients receiving any surgical warming intervention (odds ratio: 0.36; 95% confidence interval: 0.18–0.87; p<0.01) compared to individuals treated under standard care conditions, with limited further data supporting improved active warming effect in contrast with passive implementation. Secondary postoperative outcomes, including length of rehabilitative stay or wound healing score (ASEPSIS), correspondingly demonstrated greater outcomes for surgical patients receiving perioperative warming. Introduction of warming interventions consistently correlated with reduced patient-reported pain experiences (p<0.05) and downstream care expenditures (p<0.01).

Conclusion: The present review identified evidence supporting a statistically significant correlation between both active and passive perioperative warming interventions to SSI prevention. These findings strongly support the recommendation of standardised perioperative warming implementation with continued investigation of relative efficacy contrasting active and passive methodologies, and across more diverse and substantial patient population sizes.
Urinary Tract Infection in Children: A Review of the
Established Practice Guidelines
Authors: Uwaezuoke Samuel , Ayuk Adaeze , Muoneke Uzoamaka
Published: December 2021

Urinary tract infection (UTI) is a significant cause of morbidity in children. Delayed treatment is associated with complications that may result in chronic kidney disease and, subsequently, end-stage kidney disease. Over the years, clinical practice guidelines have advanced to ensure the best global practices in treating the infection and preventing its progression to chronic kidney disease. The established practice guidelines address five main questions: 1) which children should have their urine tested; 2) how the sample should be obtained; 3) which radiological tests are recommended after a diagnosis of UTI; 4) how the infection should be treated; 5) and how affected children should be followed up. There is a substantial overlap in the recommendations of the American Academy of Pediatrics (AAP) guidelines and the UK’s National Institute for Health and Clinical Excellence (NICE) guidelines. Subtle differences, however, exist between the two established guidelines. An evidence-based paradigm shift of some traditional concepts about UTI in children has contributed to the revision and update of these guidelines. Further research is needed to clarify the role of host and genetic factors in renal scarring, as well as the diagnostic criteria for UTI. This narrative review aims to discuss the current recommendations of these established practice guidelines with an emphasis on the diagnosis, radiological investigation, treatment, and follow-up of UTI in children.
CLIMATE CHANGE ADAPTATION PLAN
Authors: Ugle Pimpalkhute Prachi
Published: December 2021

Nations across have come with national adaptation plan (NAPs). The inclination towards mitigation i.e.; to reduce emissions have taken a back step and adaptation has come to forefront as even with advanced frameworks, innovation, methodological tool kits, technology and capacity building, we except nations to adapt, acclimatize, adjust and bear the consequences of climate change. Adaptation plans are focused on making the stakeholders including the entities per se to make them used to impacts rather than nudging the ways and means or processes to future proof the entire supply chain and stakeholders day to day living and functioning. Adaptation is a climate intensive attribute for not just 1.5 degrees and or NDCs targets planning, but it’s a preparedness planning fudge function. Why adapt when we can do away with just mitigation? Is what, debate is on with in the scientific think tank.
Incerteza e esforço inovativo no pensamento keynesiano e neo-schumpeteriano
Authors: Cavalcante Thiago
Published: December 2021

Este artigo analisa como elementos da teoria keynesiana e evolucionária – incerteza, investimento e a formação de expectativas – demonstram-se relevantes no processo decisório orientado à mudança teológica das firmas. Emprega-se o método epistemológico para articular a noção de temporalidade das expectativas e decisões de investimentos em inovação presente nas duas abordagens teóricas. Dentre os resultados, destaca-se que a emergência de um novo paradigma tecnológico altera a eficiência marginal do capital previamente mobilizado, visto que as inovações radicais alteram às quase-renda vinculadas aos rendimentos prospectivos dos bens de capital. Logo, as decisões de investimentos relativas a inovações radicais (longo prazo) demonstram-se mais suscetíveis à incerteza do que as decisões de investimentos em inovações incrementais (curto prazo), dado o processo de aprendizado.
THE ROLE OF CUSTODIAN IN THE FORMATION OF ART WORKS COLLECTION (on the example of educational and methodological funds of the Drawing Department of the National Academy of Fine Arts and Architecture)
Authors: Maуstrenko-Vakulenko Yuliya
Published: December 2021

Abstract. The article considers the peculiarities of formation of the collection of educational and methodical funds of the Drawing Department of the National Academy of Fine Arts and Architecture (NAFAA). The purpose of the study is to identify the role of the custodian in the process of forming the collection; determination of special professional requirements and specific range of job responsibilities of the keeper of museum collection of the institution of higher art education by studying the history of the collection. On the basis of the study of NAFAA archival materials and conversations with employees of the Academy, the list of persons responsible for the preservation of the collection of educational and methodical funds of the Drawing Department since 1937 has been established. It was found out that the position of the person responsible for the preservation of the collection of educational and methodical funds of the Drawing Department, during second half of the 20th century and the beginning of the 21st century, had different names: Head of the drawing studyroom, Educational master, Master of industrial training, Head of the educational laboratory of the Drawing Department. People who worked with the funds mostly had higher art education (or intended to acquire it): they were practicing artists, graduates of painting, graphic arts, restoration, theory and history of art, pedagogical or architectural faculties. It was noted that the process of transferring art values took place between the responsible employees without any documentary support, and the employees themselves were changing their positions almost annually until the 1990s. It was proved that the absence of appropriate position of funds keeper in the staff schedule of the KSAI-NAFAA, which requires a professional education in art history and knowledge of museum management methods, had a negative impact on the preservation of collection. Thus, the museum, which is planned to be established under the NAFAA in the near future, should become a special structural subdivision. Along with its main activity related to the acquisition, recording, storage, conservation (preservation) and restoration of museum treasures, the NAFAA museum should perform an important educational and methodological function. To the typical duties of the Head keeper of the NAFAA museum collections there should necessarily be the requirement to know the history, methods and techniques of teaching artistic disciplines, as well as to have pedagogical experience.
YULII MYKOLAIOVYCH YATCHENKO (1928–2020). MEMORIES OF THE ARTIST [publication of the document]
Authors: Maуstrenko-Vakulenko Yuliya
Published: December 2021

Abstract. The article is a publication of the memories of Yulii Mykolaiovych Yatchenko, a Ukrainian painter, graduate of the Kyiv State Art Institute (KSAI), student of S. Hryhoriev, M. Sharonov, H. Melikhov, and K. Ieleva. Yulii Yatchenko dedicated almost his entire life to pedagogical and organizational work: Director of the Republican Art Secondary School named after T.H. Shevchenko, Professor of the Department of Drawing and Vice-Rector for scientific work of the KSAI, as well as he headed the Directorate of Art Exhibitions of the Ministry of Culture of the USSR. The manuscript work «Memories of the Artist» of Yulii Mykolaiovych Yatchenko was prepared by him for printing in 2014. The manuscript contains two parts: «Memories of the Artist. The Story» and «Work on the Images of Princes and Kings». Now the first part is published, in which the author recalls both his training at the KSAI (now — «the NAFAA») and the methods of work and education of the teachers; describes moments of the creative process over the painting «With the Dream of Peace. Rescuing Works of Dresden Art Gallery by Soviet Troops in 1945» (1959) and other major paintings; revives in memories trips to Dresden and communication with the management of the Dresden Gallery, visits of the Ukrainian delegation for culture to Portugal, creative trips to Lithuania and Latvia, stay in Sedniv and Kanev; as if relives the pleasant moments associated with personal exhibitions in the halls of the National Academy of Fine Arts and Architecture. Yulii Yatchenko also draws attention to the issues of pedagogy, drawing teaching methods, reflects on the needs of creative youth. Finally, the author dives into his childhood memories, verbally describing his family and his ancestors. The feature of «Memories of the Artist» of Yulii Yatchenko is the absence of a rigid chronology and informality of presentation; the artist wrote down his own memories in the sequence in which they surfaced in his memory. After reading the «Memories», there is a feeling of personal communication with Yulii Mykolaiovych Yatchenko. The publication is a unique original testimony of the artist, a representative of that generation, whose creative path began in the difficult postwar period, in times of severe ideological constraints. The material of his memories is useful for teachers, graduate and undergraduate students, as well as connoisseurs of art in general and the creativity of Yulii Mykolaiovych Yatchenko in particular.
Honey bees show dance pattern to communicate – A review
Authors: Khan Momin Aziz , Sulehri Naiha Ijaz , Talha Muhammad , Nazar Aqsa , Ahmed Hafiz Ghulam Muhu-Din
Published: December 2021

The honey bee language is considered by many to be one of the most interesting systems for animal communications, used for recruitment to food sources. Honeybee's forager dancers communicate food and other resources to the household by quantity, consistency, direction, and spatial location. The waggle dance was interesting and complex, which bees used for spatial information on desired resources. All honeybee species use the waggle dance to convey their position and distance from food sources and possible new nest sites. The research was carried out on dance communication, earlier ideas, controversies, and solutions gave a broad overview. In this analysis, unique problems are focused on as follows: (a) multiple dance forms. (b) Distance and path calculation (c) How bees do dark hive dance.? Several experiments verified that bees perform various kinds of dance, depending on their particular task. There is, however, still a lack of comprehensive knowledge on other types of dances, which help us solve numerous questions and help us better understand the meaning of the different kinds of dances carried in and outside the hive by honeybees.
Frequency of Streptococcus mutants in patients having dental caries; a data from clinical setting in rural area of Balochistan
Authors: Muhammad Eid , Butt Saima Akram , Shaheen Shehla , Khan Tamoor
Published: December 2021

To assess the frequency of streptococcus mutans (S. mutans) and its association with socio-demographic factors in patients having dental caries presenting at a DHQ hospital in rural area of Balochistan. It was a cross-sectional study conducted at the clinical setting or DHQ hospital of a rural area in Balochistan from April 2020 January 2021. About 120 patients of age 18 to 40 years of either gender presenting dental caries were included in the study using non-random consecutive sampling technique. Data regarding age, gender, ethnicity, addictions (like gutka and smoking) pH level and oral hygiene was obtained from all the participants by researcher himself. The number of S. mutans colonies (CFU) was counted using a self-illuminating binocular microscope after plates were incubated for 48 hours at 37°C. All findings were entered into a pre-designed proforma. SPSS version 23 was used to analyze data. The median age of patients with dental caries was 28 years (IQR: 21-35 years) and 83.3% of the patients were males. The median S. mutans count of all the patients with dental caries was estimated as 35 with IQR as 32 to 38. Mann-Whitney statistics showed significant difference between ethnic groups for S. mutans count (p=0.049). A weak correlation was observed between S. Mutans count and pH level (r=0.206) with statistically insignificant difference (p=0.206). Frequency of S. mutans is 100% in individuals with dental caries. S. mutan counts have a significant association with ethnicity and weak correlation with pH in saliva.
StartLink and StartLink+: Prediction of Gene Starts in Prokaryotic Genomes
Authors: Gemayel Karl , Lomsadze Alexandre , Borodovsky Mark
Published: December 2021

State-of-the-art algorithms of ab initio gene prediction for prokaryotic genomes were shown to be sufficiently accurate. A pair of algorithms would agree on predictions of gene 3′ends. Nonetheless, predictions of gene starts would not match for 15–25% of genes in a genome. This discrepancy is a serious issue that is difficult to be resolved due to the absence of sufficiently large sets of genes with experimentally verified starts. We have introduced StartLink that infers gene starts from conservation patterns revealed by multiple alignments of homologous nucleotide sequences. We also have introduced StartLink+ combining both ab initio and alignment-based methods. The ability of StartLink to predict the start of a given gene is restricted by the availability of homologs in a database. We observed that StartLink made predictions for 85% of genes per genome on average. The StartLink+ accuracy was shown to be 98–99% on the sets of genes with experimentally verified starts. In comparison with database annotations, we observed that the annotated gene starts deviated from the StartLink+ predictions for ∼5% of genes in AT-rich genomes and for 10–15% of genes in GC-rich genomes on average. The use of StartLink+ has a potential to significantly improve gene start annotation in genomic databases.