bluuebunny/crossref_metadata_2025 huggingface dataset:
Dies1/VISTA expression loss is a recurrent event in gastric cancer due to epigenetic regulation
Authors: Oliveira Patrícia , Carvalho Joana , Rocha Sara , Azevedo Mafalda , Reis Inês , Camilo Vânia , Sousa Bárbara , Valente Sofia , Paredes Joana , Almeida Raquel , Huntsman David , Oliveira Carla
Published: October 2016

Dies1/VISTA induces embryonic stem-cell differentiation, via BMP-pathway, but also acts as inflammation regulator and immune-response modulator. Dies1 inhibition in a melanoma-mouse model led to increased tumour-infiltrating T-cells and decreased tumour growth, emphasizing Dies1 relevance in tumour-microenvironment. Dies1 is involved in cell de/differentiation, inflammation and cancer processes, which mimic those associated with Epithelial-to-Mesenchymal-Transition (EMT). Despite this axis linking Dies1 with EMT and cancer, its expression, modulation and relevance in these contexts is unknown. To address this, we analysed Dies1 expression, its regulation by promoter-methylation and miR-125a-5p overexpression, and its association with BMP-pathway downstream-effectors, in a TGFβ1-induced EMT-model, cancer cell-lines and primary samples. We detected promoter-methylation as a mechanism controlling Dies1 expression in our EMT-model and in several cancer cell-lines. We showed that the relationship between Dies1 expression and BMP-pathway effectors observed in the EMT-model, was not present in all cell-lines, suggesting that Dies1 has other cell-specific effectors, beyond the BMP-pathway. We further demonstrated that: Dies1 expression loss is a recurrent event in GC, caused by promoter methylation and/or miR-125a-5p overexpression and; GC-microenvironment myofibroblasts overexpress Dies1. Our findings highlight Dies1 as a novel player in GC, with distinct roles within tumour cells and in the tumour-microenvironment.
The 1257 Samalas eruption (Lombok, Indonesia): the single greatest stratospheric gas release of the Common Era
Authors: Vidal Céline M. , Métrich Nicole , Komorowski Jean-Christophe , Pratomo Indyo , Michel Agnès , Kartadinata Nugraha , Robert Vincent , Lavigne Franck
Published: October 2016

Large explosive eruptions inject volcanic gases and fine ash to stratospheric altitudes, contributing to global cooling at the Earth’s surface and occasionally to ozone depletion. The modelling of the climate response to these strong injections of volatiles commonly relies on ice-core records of volcanic sulphate aerosols. Here we use an independent geochemical approach which demonstrates that the great 1257 eruption of Samalas (Lombok, Indonesia) released enough sulphur and halogen gases into the stratosphere to produce the reported global cooling during the second half of the 13th century, as well as potential substantial ozone destruction. Major, trace and volatile element compositions of eruptive products recording the magmatic differentiation processes leading to the 1257 eruption indicate that Mt Samalas released 158 ± 12 Tg of sulphur dioxide, 227 ± 18 Tg of chlorine and a maximum of 1.3 ± 0.3 Tg of bromine. These emissions stand as the greatest volcanogenic gas injection of the Common Era. Our findings not only provide robust constraints for the modelling of the combined impact of sulphur and halogens on stratosphere chemistry of the largest eruption of the last millennium, but also develop a methodology to better quantify the degassing budgets of explosive eruptions of all magnitudes.
Dual Roles of IFN-γ and IL-4 in the Natural History of Murine Autoimmune Cholangitis: IL-30 and Implications for Precision Medicine
Authors: Syu Bi-Jhen , Loh Chia-En , Hsueh Yu-Hsin , Gershwin M. Eric , Chuang Ya-Hui
Published: October 2016

Primary biliary cirrhosis (PBC) is a progressive autoimmune liver disease with a long natural history. The pathogenesis of PBC is thought to be orchestrated by Th1 and/or Th17. In this study, we investigated the role of CD4+ helper T subsets and their cytokines on PBC using our previous established murine model of 2-OA-OVA immunization. We prepared adeno-associated virus (AAV)-IFN-γ and AAV-IL-4 and studied their individual influences on the natural history of autoimmune cholangitis in this model. Administration of IFN-γ significantly promotes recruitment and lymphocyte activation in the earliest phases of autoimmune cholangitis but subsequently leads to downregulation of chronic inflammation through induction of the immunosuppressive molecule IL-30. In contrast, the administration of IL-4 does not alter the initiation of autoimmune cholangitis, but does contribute to the exacerbation of chronic liver inflammation and fibrosis. Thus Th1 cells and IFN-γ are the dominant contributors in the initiation phase of this model but clearly may have different effects as the disease progress. In conclusion, better understanding of the mechanisms by which helper T cells function in the natural history of cholangitis is essential and illustrates that precision medicine may be needed for patients with PBC at various stages of their disease process.
Calcium dysregulation contributes to neurodegeneration in FTLD patient iPSC-derived neurons
Authors: Imamura Keiko , Sahara Naruhiko , Kanaan Nicholas M. , Tsukita Kayoko , Kondo Takayuki , Kutoku Yumiko , Ohsawa Yutaka , Sunada Yoshihide , Kawakami Koichi , Hotta Akitsu , Yawata Satoshi , Watanabe Dai , Hasegawa Masato , Trojanowski John Q. , Lee Virginia M.-Y. , Suhara Tetsuya , Higuchi Makoto , Inoue Haruhisa
Published: October 2016

Mutations in the gene MAPT encoding tau, a microtubules-associated protein, cause a subtype of familial neurodegenerative disorder, known as frontotemporal lobar degeneration tauopathy (FTLD-Tau), which presents with dementia and is characterized by atrophy in the frontal and temporal lobes of the brain. Although induced pluripotent stem cell (iPSC) technology has facilitated the investigation of phenotypes of FTLD-Tau patient neuronal cells in vitro, it remains unclear how FTLD-Tau patient neurons degenerate. Here, we established neuronal models of FTLD-Tau by Neurogenin2-induced direct neuronal differentiation from FTLD-Tau patient iPSCs. We found that FTLD-Tau neurons, either with an intronic MAPT mutation or with an exonic mutation, developed accumulation and extracellular release of misfolded tau followed by neuronal death, which we confirmed by correction of the intronic mutation with CRISPR/Cas9. FTLD-Tau neurons showed dysregulation of the augmentation of Ca2+ transients evoked by electrical stimulation. Chemogenetic or pharmacological control of neuronal activity-relevant Ca2+ influx by the introduction of designer receptors exclusively activated by designer drugs (DREADDs) or by the treatment with glutamate receptor blockers attenuated misfolded tau accumulation and neuronal death. These data suggest that neuronal activity may regulate neurodegeneration in tauopathy. This FTLD-Tau model provides mechanistic insights into tauopathy pathogenesis and potential avenues for treatments.
Multiple discrete soluble aggregates influence polyglutamine toxicity in a Huntington’s disease model system
Authors: Xi Wen , Wang Xin , Laue Thomas M. , Denis Clyde L.
Published: October 2016

Huntington’s disease (HD) results from expansions of polyglutamine stretches (polyQ) in the huntingtin protein (Htt) that promote protein aggregation, neurodegeneration, and death. Since the diversity and sizes of the soluble Htt-polyQ aggregates that have been linked to cytotoxicity are unknown, we investigated soluble Htt-polyQ aggregates using analytical ultracentrifugation. Soon after induction in a yeast HD model system, non-toxic Htt-25Q and cytotoxic Htt-103Q both formed soluble aggregates 29S to 200S in size. Because current models indicate that Htt-25Q does not form soluble aggregates, reevaluation of previous studies may be necessary. Only Htt-103Q aggregation behavior changed, however, with time. At 6 hr mid-sized aggregates (33S to 84S) and large aggregates (greater than 100S) became present while at 24 hr primarily only mid-sized aggregates (20S to 80S) existed. Multiple factors that decreased cytotoxicity of Htt-103Q (changing the length of or sequences adjacent to the polyQ, altering ploidy or chaperone dosage, or deleting anti-aging factors) altered the Htt-103Q aggregation pattern in which the suite of mid-sized aggregates at 6 hr were most correlative with cytotoxicity. Hence, the amelioration of HD and other neurodegenerative diseases may require increased attention to and discrimination of the dynamic alterations in soluble aggregation processes.
A novel Al matrix composite reinforced by nano-AlNp network
Authors: Ma X. , Zhao Y. F. , Tian W. J. , Qian Z. , Chen H. W. , Wu Y. Y. , Liu X. F.
Published: October 2016

In pursuit of lightweighting of automobiles and low emission of transportation, the efforts to develop high-strength, heat-resistant and fatigue-resistant Al alloys and/or composites have been ongoing. Here we report a novel Al matrix composite with ultrahigh strength reinforced by a three dimensional network of nano-AlN particles for the first time. The in-situ synthesized AlN particles are connected by twinning bonding chains and built up a three dimensional network strengthening Al matrix enormously like the skeleton to human body. The composite containing 16.4wt.% AlN particles shows excellent properties: the ultimate tensile strengths can be up to 518MPa at room temperature and 190MPa at 350 °C. This peculiar performance results from the novel spatial distribution of nano-scale AlN particles. Our findings in this work would help to develop a potential candidate for high-performance heat resistance light-metal based materials.
Pathological Assessment of Rectal Cancer after Neoadjuvant Chemoradiotherapy: Distribution of Residual Cancer Cells and Accuracy of Biopsy
Authors: Xiao Lin , Yu Xin , Deng Wenjing , Feng Huixia , Chang Hui , Xiao Weiwei , Zhang Huizhong , Xi Shaoyan , Liu Mengzhong , Zhu Yujia , Gao Yuanhong
Published: October 2016

We investigated the distribution of residual cancer cells (RCCs) within different layers of the bowel wall in surgical specimens and the value of biopsies of primary rectal lesion after preoperative volumetric modulated arc therapy (VMAT) with concurrent chemotherapy in patients with rectal cancer. Between April 2011 and April 2013, 178 patients with rectal cancer who received preoperative VMAT, concurrent chemotherapy, and surgery were evaluated; 79 of the patients received a biopsy of the primary lesion after chemoradiotherapy and prior to surgery. The distribution of RCCs in the surgical specimens and the sensitivity and specificity of the biopsy of primary rectal lesions for pathological response were evaluated. Fifty-two patients had a complete pathological response in the bowel wall. Of the 120 patients with ypT2-4, the rate of detection of RCCs in the mucosa, submucosa, and muscularis propria was 20%, 36.7%, 69.2%, respectively. The sensitivity and specificity of biopsies of primary rectal lesions was 12.9% and 94.1%, respectively. After chemoradiotherapy, the RCCs were primarily located in the deeper layers of the bowel wall, and the biopsy results for primary rectal lesions were unreliable due to poor sensitivity.
Structurally Efficient Three-dimensional Metamaterials with Controllable Thermal Expansion
Authors: Xu Hang , Pasini Damiano
Published: October 2016

The coefficient of thermal expansion (CTE) of architected materials, as opposed to that of conventional solids, can be tuned to zero by intentionally altering the geometry of their structural layout. Existing material architectures, however, achieve CTE tunability only with a sacrifice in structural efficiency, i.e. a drop in both their stiffness to mass ratio and strength to mass ratio. In this work, we elucidate how to resolve the trade-off between CTE tunability and structural efficiency and present a lightweight bi-material architecture that not only is stiffer and stronger than other 3D architected materials, but also has a highly tunable CTE. Via a combination of physical experiments on 3D fabricated prototypes and numeric simulations, we demonstrate how two distinct mechanisms of thermal expansion appearing in a tetrahedron, can be exploited in an Octet lattice to generate a large range of CTE values, including negative, zero, or positive, with no loss in structural efficiency. The novelty and simplicity of the proposed design as well as the ease in fabrication, make this bi-material architecture well-suited for a wide range of applications, including satellite antennas, space optical systems, precision instruments, thermal actuators, and MEMS.
Synergistic Communication between CD4+ T Cells and Monocytes Impacts the Cytokine Environment
Authors: Schrier Sarah B. , Hill Abby S. , Plana Deborah , Lauffenburger Douglas A.
Published: October 2016

Physiological cytokine environments arise from factors produced by diverse cell types in coordinated concert. Understanding the contributions of each cell type in the context of cell-cell communication is important for effectively designing disease modifying interventions. Here, we present multi-plexed measurement of 48 cytokines from a coculture system of primary human CD4+ T cells and monocytes across a spectrum of stimuli and for a range of relative T cell/monocyte compositions, coupled with corresponding measurements from PBMCs and plasma from the same donors. Computational analysis of the resulting data-sets elucidated communication-independent and communication-dependent contributions, including both positive and negative synergies. We find that cytokines in cell supernatants were uncorrelated to those found in plasma. Additionally, as an example of positive synergy, production levels of CXCR3 cytokines IP-10 and MIG, depend non-linearly on both IFNγ and TNFα levels in cross-talk between T cells and monocytes. Overall, this work demonstrates that communication between cell types can significantly impact the consequent cytokine environment, emphasizing the value of mixed cell population studies.
Mu rhythm suppression reflects mother-child face-to-face interactions: a pilot study with simultaneous MEG recording
Authors: Hasegawa Chiaki , Ikeda Takashi , Yoshimura Yuko , Hiraishi Hirotoshi , Takahashi Tetsuya , Furutani Naoki , Hayashi Norio , Minabe Yoshio , Hirata Masayuki , Asada Minoru , Kikuchi Mitsuru
Published: October 2016

Spontaneous face-to-face interactions between mothers and their children play crucial roles in the development of social minds; however, these inter-brain dynamics are still unclear. In this pilot study, we measured MEG mu suppression during face-to-face spontaneous non-linguistic interactions between mothers and their children with autism spectrum disorder (ASD) using the MEG hyperscanning system (i.e., simultaneous recording). The results demonstrated significant correlations between the index of mu suppression (IMS) in the right precentral area and the traits (or severity) of ASD in 13 mothers and 8 children (MEG data from 5 of the children could not be obtained due to motion noise). In addition, higher IMS values (i.e., strong mu suppression) in mothers were associated with higher IMS values in their children. To evaluate the behavioral contingency between mothers and their children, we calculated cross correlations between the magnitude of the mother and child head-motion during MEG recordings. As a result, in mothers whose head motions tended to follow her child’s head motion, the magnitudes of mu suppression in the mother’s precentral area were large. Further studies with larger sample sizes, including typically developing children, are necessary to generalize this result to typical interactions between mothers and their children.
The relationships between HLA class II alleles and antigens with gestational diabetes mellitus: A meta-analysis
Authors: Guo Cong-cong , Jin Yi-mei , Lee Kenneth Ka Ho , Yang Guang , Jing Chun-xia , Yang Xuesong
Published: October 2016

Gestational diabetes mellitus (GDM) is defined as glucose intolerance with onset or first recognition during pregnancy. It is associated with an increased risk of pregnancy complications. Susceptibility to GDM is partly determined by genetics and linked with type 1 diabetes-associated high risk HLA class II genes. However, the evidence for this relationship is still highly controversial. In this study, we assessed the relationship between HLA class II variants and GDM. We performed meta-analysis on all of literatures available in PubMed, Embase, Web of Science and China National Knowledge Infrastructure databases. The odds ratio and 95% confidence interval of each variant were estimated. All statistical analyses were conducted using the Comprehensive Meta Analysis 2.2.064 software. At the allelic analysis, DQB1*02, DQB1*0203, DQB1*0402, DQB1*0602, DRB1*03, DRB1*0301 and DRB1*1302 reached a nominal level of significance, and only DQB1*02, DQB1*0602 and DRB1*1302 were statistically significant after Bonferroni correction. At the serological analysis, none of DQ2, DQ6, DR13 and DR17 was statistically significant following Bonferroni correction although they reached a nominal level of significance. In sum, our meta-analysis demonstrated that there were the associations between HLA class II variants and GDM but more studies are required to elucidate how these variants contribute to GDM susceptibility.
Development, validation and application of a device to measure e-cigarette users’ puffing topography
Authors: Cunningham Anthony , Slayford Sandra , Vas Carl , Gee Jodie , Costigan Sandra , Prasad Krishna
Published: October 2016

With the rapidly rising popularity and substantial evolution of electronic cigarettes (e-cigarettes) in the past 5–6 years, how these devices are used by vapers and consumers’ exposure to aerosol emissions need to be understood. We used puffing topography to measure directly product use. We adapted a cigarette puffing topography device for use with e-cigarettes. We performed validation using air and e-cigarette aerosol under multiple regimes. Consumer puffing topography was measured for 60 vapers provided with rechargeable “cig-a-like” or larger button-activated e-cigarettes, to use ad-libitum in two sessions. Under all regimes, air puff volumes were within 1 mL of the target and aerosol volumes within 5 mL for all device types, serving to validate the device. Vapers’ mean puff durations (2.0 s and 2.2 s) were similar with both types of e-cigarette, but mean puff volumes (52.2 mL and 83.0 mL) and mean inter-puff intervals (23.2 s and 29.3 s) differed significantly. The differing data show that product characteristics influence puffing topography and, therefore, the results obtained from a given e-cigarette might not read across to other products. Understanding the factors that affect puffing topography will be important for standardising testing protocols for e-cigarette emissions.
Combined covalent and noncovalent carboxylation of carbon nanotubes for sensitivity enhancement of clinical immunosensors
Authors: Niroula Jinesh , Premaratne Gayan , Ali Shojaee S. , Lucca Don A. , Krishnan Sadagopan
Published: October 2016

Combined covalent and non-covalent functionalization of carbon nanostructures for sensitivity amplification of biosensors.
Ru(ii)-Catalyzed C–H activation and annulation of salicylaldehydes with monosubstituted and disubstituted alkynes
Authors: Baruah Swagata , Kaishap Partha Pratim , Gogoi Sanjib
Published: October 2016

An Ru(ii) catalyst was used for the annulation reaction of terminal/disubstituted alkynes with salicylaldehydes to afford chromones.
Two-dimensional metal–organic framework nanosheets as a matrix for laser desorption/ionization of small molecules and monitoring enzymatic reactions at high salt concentrations
Authors: Liu Hai-Long , Chang Yu-Jie , Fan Ting , Gu Zhi-Yuan
Published: October 2016

Stable 2-D metal–organic framework nanosheets as a MALDI matrix for small molecule analysis and monitoring enzymatic reactions at high salt concentrations.
Carbon-rich “Click” 1,2,3-triazoles: hexaphenylbenzene and hexa-peri-hexabenzocoronene-based ligands for Suzuki–Miyaura catalysts
Authors: Wright James R. , Crowley James D. , Lucas Nigel T.
Published: October 2016

Routes to polyaromatic 1,2,3-triazole ligands have been developed, their [PdCl2L2] complexes characterised and assessed as precatalysts in the Suzuki–Miyaura reaction.
Understanding charge transport in non-doped pristine and surface passivated hematite (Fe2O3) nanorods under front and backside illumination in the context of light induced water splitting
Authors: Bassi Prince Saurabh , Xianglin Li , Fang Yanan , Loo Joachim Say Chye , Barber James , Wong Lydia Helena
Published: October 2016

This work reports an in-depth study of the performance of hematite nanorods under back and front illumination while varying the crucial annealing temperature.
Oxygen diffusion and surface exchange in the mixed conducting oxides SrTi1−yFeyO3−δ
Authors: Metlenko Veronika , Jung WooChul , Bishop Sean R. , Tuller Harry L. , De Souza Roger A.
Published: October 2016

Variation of the surface exchange coefficient with Fe concentration suggests single mechanism of oxygen exchange for e−-poor and e−-rich SrTi1−yFeyO3−δoxides.
Intramolecular torque, an indicator of the internal rotation direction of rotor molecules and similar systems
Authors: Zhang Rui-Qin , Zhao Yan-Ling , Qi Fei , Hermann Klaus , Van Hove Michel A.
Published: October 2016

Rotation-inducing torque being ubiquitous in many molecular systems is the driving force of the molecular internal rotation and an indicator of the rotation direction.
It is no laughing matter: nitrous oxide formation in diesel engines and advances in its abatement over rhodium-based catalysts
Authors: Jabłońska Magdalena , Palkovits Regina
Published: October 2016

N2O appears as one of the undesired by-products in exhaust gases emitted from diesel engine aftertreatment systems, such as diesel oxidation catalysts (DOC), lean NOx trap (LNT, also known as NOx storage and reduction (NSR)) or selective catalytic reduction (NH3-SCR and HC-SCR) and ammonia slip catalysts (ASC, AMOX, guard catalyst).
Silica-supported chlorometallate(iii) ionic liquids as recyclable catalysts for Diels–Alder reaction under solventless conditions
Authors: Matuszek Karolina , Chrobok Anna , Latos Piotr , Markiton Magdalena , Szymańska Katarzyna , Jarzębski Andrzej , Swadźba-Kwaśny Małgorzata
Published: October 2016

The first catalytic application of supported chlorometallate(iii) ionic liquids as recyclable heterogeneous catalysts for a Diels–Alder reaction under solventless conditions.
Diruthenium(ii)–NNN pincer complex catalysts for transfer hydrogenation of ketones
Authors: Chai Huining , Wang Qingfu , Liu Tingting , Yu Zhengkun
Published: October 2016

A strategy to construct highly efficient diruthenium(ii)–NNN pincer complex catalysts was established for the transfer hydrogenation of ketones.
Zr and Y co-doped perovskite as a stable, high performance cathode for solid oxide fuel cells operating below 500 °C
Authors: Duan Chuancheng , Hook David , Chen Yachao , Tong Jianhua , O'Hayre Ryan
Published: October 2016

BaCo0.4Fe0.4Zr0.1Y0.1O3−δis applied for the first time as a cathode for low-temperature solid oxide fuel cells (LT-SOFCs) with high power densities below 500 °C and 2500 hours stable performance.
The mechanism of chronic toxicity to Daphnia magna induced by graphene suspended in a water column
Authors: Fan Wenhong , Liu Yingying , Xu Zhizhen , Wang Xiangrui , Li Xiaomin , Luo Shenglian
Published: October 2016

The mechanism of chronic toxicity induced by graphene toDaphnia magnacompared with that of C60, SWCNT, and MWCNT.
Antioxidant balance and accumulation of advanced glycation end products after the consumption of standard diets including Maillard reaction products from silver carp peptides
Authors: Yao Ye , Han Kaining , Dong Shiyuan , Zeng Mingyong , Liu Zunying
Published: October 2016

The oxidative stress of diabetic mice fed on peptide MRPs with high AGE levels was aggravated, and the uptake of CML correlated with excretion but affected the accumulation in organs to a lesser extent.
Biocatalytic stereoinversion ofd-para-bromophenylalanine in a one-pot three-enzyme reaction
Authors: Khorsand Fahimeh , Murphy Cormac D. , Whitehead Andrew J. , Engel Paul C.
Published: October 2016

d-Amino acid transaminase plus mutant phenylalanine dehydrogenase offer an effective one-pot system for 100% conversion ofdl-amino acids to thel-form.
Enhancement of dielectric constant in a niobium doped titania system: an experimental and theoretical study
Authors: Mandal Balaji P. , Anithakumari P. , Nigam Sandeep , Majumder Chiranjib , Mohapatra Manoj , Tyagi Avesh K.
Published: October 2016

A very high dielectric constant of Nb doped titania is observed due to both the interfacial effect and formation of complex defect dipoles.
Stereoselective photoreaction in P-stereogenic dithiazolylbenzo[b]phosphole chalcogenides
Authors: Iijima Shunsuke , Nakashima Takuya , Kawai Tsuyoshi
Published: October 2016

The diastereoselective photoreaction of dithiazolylbenzo[b]phosphole chalcogenides was achieved by means of the conformational control of the photoprecursor state by intramolecular interactions involving the stereogenic phosphorus.
Tuneable 2D self-assembly of plasmonic nanoparticles at liquid|liquid interfaces
Authors: Velleman Leonora , Sikdar Debabrata , Turek Vladimir A. , Kucernak Anthony R. , Roser Steve J. , Kornyshev Alexei A. , Edel Joshua B.
Published: October 2016

Validation of the plasmon ruler through small angle X-ray diffraction and optical reflectance of ordered nanoparticle films at the liquid–liquid interface.
A theoretical study of the Duff reaction: insights into its selectivity
Authors: Grimblat Nicolás , Sarotti Ariel M. , Kaufman Teodoro S. , Simonetti Sebastian O.
Published: October 2016

The selectivity-determining step of the Duff ortho-formylation was studied using DFT calculations; a hydrogen bond establishes the position where the formylation will take place.
Synthesis of 28a-homoselenolupanes and 28a-homoselenolupane saponins
Authors: Sidoryk Katarzyna , Rárová Lucie , Oklešťková Jana , Pakulski Zbigniew , Strnad Miroslav , Cmoch Piotr , Luboradzki Roman
Published: October 2016

A facile synthesis of 28a-homoselenolupanes was demonstrated. Glycosylation of free selenol afforded 28a-homoselenolupane saponins.
Protein-engineering of an amine transaminase for the stereoselective synthesis of a pharmaceutically relevant bicyclic amine
Authors: Weiß Martin S. , Pavlidis Ioannis V. , Spurr Paul , Hanlon Steven P. , Wirz Beat , Iding Hans , Bornscheuer Uwe T.
Published: October 2016

Application of amine transaminases (ATAs) for stereoselective amination of prochiral ketones represents an environmentally benign and economically attractive alternative to transition metal catalyzed asymmetric synthesis.
Preparation of glucose responsive polyelectrolyte capsules with shell crosslinking via the layer-by-layer technique and sustained release of insulin
Authors: Shi Dongjian , Ran Maoshuang , Huang He , Zhang Li , Li Xiaojie , Chen Mingqing , Akashi Mitsuru
Published: October 2016

(Alg/CS-g-CPBAm)n capsules were fabricated to study the effect of the capsule structure on the glucose sensitivity and sustained release of insulin.
A copper–amyloid-β targeted fluorescent chelator as a potential theranostic agent for Alzheimer's disease
Authors: Yang Tao , Yang Liu , Zhang Changli , Wang Yanqing , Ma Xiang , Wang Kun , Luo Jian , Yao Cheng , Wang Xiaoyong , Wang Xiaohui
Published: October 2016

A fluorescent chelator is able to specifically target and attenuate Cu2+–Aβ aggregates in the brain of mice with Alzheimer's disease, which can be visualized by fluorescence imaging of the chelator.
Investigation of supramolecular interactions between liquid crystals and PCBM for improved morphological stability in solar cells
Authors: Zhou Weihua , Hu Kunxing , Shen Xingxing , Xie Yuanpeng , Zhang Lin , Ai Qingyun , Yin Jingping , Chen Yiwang
Published: October 2016

Supramolecular interactions between liquid crystals and PC61BM restrict the aggregation of PC61BM for improved morphological stability, depending on the chemical structure.
Nickel-catalyzed direct formation of the C–S bonds of aryl sulfides from arylsulfonyl chlorides and aryl iodides using Mn as a reducing agent
Authors: Wang Yang , Zhang Xiaofeng , Liu Haixiong , Chen Hui , Huang Deguang
Published: October 2016

Unsymmetrical aryl sulfides were synthesized by nickel-catalyzed arylsulfonyl chlorides and aryl iodides via intermediate disulfides using Mn as a reducing agent.
Side-chain-type quaternized naphthalene-based poly(arylene ether ketone)s for anhydrous high temperature proton exchange membranes
Authors: Li Guibin , Zhao Chengji , Zhu Chongyi , Ru Chunyu , Li Xuefeng , Qi Duo , Wei Yuxue , Na Hui
Published: October 2016

The PA/Q-SCT-NPAEK-xx membranes with good proton conductivity, mechanical and thermal stabilities were prepared successfully.
Degradation of 2,4-dichlorophenol from aqueous using UV activated persulfate: kinetic and toxicity investigation
Authors: Chen Juxiang , Gao Naiyun , Lu Xian , Xia Meng , Gu Zhenchuan , Jiang Chuang , Wang Qiongfang
Published: October 2016

2,4-DCP is a high-toxicity phenol compound, which is difficult to remove, harmful to the health of people and seriously influences the aquatic ecosystems.
Effect of freezing rate on rheological, thermal and structural properties of frozen wheat starch
Authors: Tao Han , Wang Pei , Wu Fengfeng , Jin Zhengyu , Xu Xueming
Published: October 2016

Native wheat starch was frozen at different rates (0.18, 0.37 and 1.54 °C min−1) and then evaluated for dough making.
Hyaluronic acid/EDC/NHS-crosslinked green electrospun silk fibroin nanofibrous scaffolds for tissue engineering
Authors: Yang Xingxing , Wang Xiaoyun , Yu Fan , Ma Linlin , Pan Xiaohan , Luo Gejie , Lin Si , Mo Xiumei , He Chuanglong , Wang Hongsheng
Published: October 2016

The mechanical properties of SF nanofibrous matrices were enhanced through crosslinking with HA/EDC/NHS for soft tissue engineering.
Syntheses, structures and magnetic properties of symmetrical Schiff-base supported dinuclear Ln(iii) compounds
Authors: Lin Shuang-Yan , Wang Chunlai , Xu Zhikun
Published: October 2016

Two dinuclear Dy(iii) compounds bridged by respectivesyn–synη1:η1-µ2-benzoato and µ2-O alkoxido groups have been synthesized by symmetrical two-arm and four-arm ligands, respectively, which show field-induced slow relaxation phenomenon.
A novel hierachically-nanostructured Pt/SiO2/Fe3O4 catalyst with high activity and recyclability towards hydrosilylation
Authors: Zai Huachao , Zhao Yizhou , Chen Shanyu , Wang Rui , Ge Lei , Chen Changfeng , Li Yujing
Published: October 2016

Ultrafine Pt nanoparticles immobilized on the SiO2/Fe3O4 support show high activity towards the hydrosilylation.
Influence of free fatty acid content on the oxidative stability of red palm oil
Authors: De Leonardis Antonella , Cuomo Francesca , Macciola Vincenzo , Lopez Francesco
Published: October 2016

A multi-technique approach used for the characterization of the oxidative stability of red palm.
Self-healing epoxy with a fast and stable extrinsic healing system based on BF3–amine complex
Authors: Song Yi Xi , Ye Xiao Ji , Rong Min Zhi , Zhang Ming Qiu
Published: October 2016

An easily processed healing system consisting of BF3–amine complex and cycloaliphatic epoxy monomer enables fast healing of cured epoxy within seconds.
Enhancing the photovoltaic performance of binary acceptor-based conjugated polymers incorporating methyl units
Authors: Feng Guitao , Xu Yunhua , Wu Yang , Li Cheng , Yang Fan , Yu Yaping , Ma Wei , Li Weiwei
Published: October 2016

“Binary acceptors” conjugated polymers with methyl side units were found to provide high photocurrent and efficiency in solar cells due to the small crystal domain of polymers in blended thin films.
Manganese oxide films with controlled oxidation state for water splitting devices through a combination of atomic layer deposition and post-deposition annealing
Authors: Mattelaer Felix , Bosserez Tom , Rongé Jan , Martens Johan A. , Dendooven Jolien , Detavernier Christophe
Published: October 2016

Manganese oxide thin films were obtained by a combination of atomic layer deposition and post-deposition annealing, and the viability of these thin films as thin film catalysts for solar hydrogen devices has been demonstrated.
The enantioselective metabolic mechanism of quizalofop-ethyl and quizalofop-acid enantiomers in animal: protein binding, intestinal absorption, and in vitro metabolism in plasma and the microsome
Authors: Liang Yiran , Wang Peng , Liu Donghui , Zhan Jing , Luo Mai , Han Jiajun , Jing Xu , Yao Guojun , Zhou Zhiqiang
Published: October 2016

The effects of protein binding (pepsin, trypsin and serum albumin), intestinal absorption (everted gut sac), and degradation (plasma, liver microsome and cytosol) on the enantioselectivity of quizalofop-ethyl in animals were studiedin vitro.
Smart-phone attachable, flow-assisted magnetic focusing device
Authors: Amin Reza , Knowlton Stephanie , Yenilmez Bekir , Hart Alexander , Joshi Ashwini , Tasoglu Savas
Published: October 2016

We present a smart-phone attachable continuous flow magnetic focusing device as an inexpensive and portable tool for real-time detection, monitoring, and sorting of particles in high-volume samples based on their volumetric mass density.
Mixed calcium and zinc salts of N-(3-amino-benzoic acid)terpene-maleamic acid: preparation and its application as novel thermal stabilizer for poly(vinyl chloride)
Authors: Wang Mei , Xia Jianling , Jiang Jianchun , Li Shouhai , Li Mei
Published: October 2016

N-(3-Amino-benzoic acid)terpene-maleamic acid was successfully prepared, and converted to the corresponding good efficient Ca/Zn-based thermal stabilizers for poly(vinyl chloride).
The effect of magnetite on the start-up and N2O emission reduction of the anammox process
Authors: Lv Lu , Ren Long-Fei , Ni Shou-Qing , Gao Bao-Yu , Wang Yi-Nan
Published: October 2016

A reactor combined with magnetite could enhance the anammox performance and enrich morePlanctomycetesbacteria.
Two polymolybdate-based complexes and their graphene composites with visible-light photo-responses
Authors: Luo Hai-Qiang , Zhang Pan , Yang Yong-Xi , Gong Yun , Lin Jian-Hua
Published: October 2016

Two polymolybdate-based complexes with different band gaps show different visible-light photo-responses, and their graphene composite materials possess improved electrocatalytic activities for HER.
Well-defined quantum dots and broadening of optical phonon line from hydrothermal method
Authors: Jamwal Deepika , Rana Dolly , Singh Pardeep , Pathak Dinesh , Kalia Susheel , Thakur Pankaj , Torino Enza
Published: October 2016

A versatile and facile methodology is presented for size-controlled, lead telluride nanoparticles in the presence of highly hydrophobic cationic gemini surfactants (12–2–12, 14–2–14 and 16–2–16) as capping/stabilizing agents.
Enhanced microwave absorbing properties of PANI/CoFe2O4/PVDF composite
Authors: Yang Haibo , Han Ning , Lin Ying , Zhang Ge , Wang Lei
Published: October 2016

Polyaniline/CoFe2O4/polyvinylidene fluoride (PANI/CoFe2O4/PVDF) composites were synthesized by an in situ polymerization method.
Broadening the range of vesicle formation by heating
Authors: Liu Songlin , Liu Cuicui , Song Xiaohui , Kim Il , Chen Hongyu
Published: October 2016

Vesicles of amphiphilic block copolymers have been extensively studied, but surprisingly few studies used high temperature to promote the polymer shape evolution towards vesicles.
Solution-grown GeO2 nanoparticles with a nearly 100% yield as lithium-ion battery anodes
Authors: Li Guo-An , Li Wei-Chin , Chang Wei-Chung , Tuan Hsing-Yu
Published: October 2016

Germanium oxide (GeO2) nanoparticles were synthesized with a nearly 100% production yield in a nonionic reverse micelle system at ambient temperature as high performance lithium-ion battery anodes.
Facile one-pot synthesis of carbon incorporated three-dimensional hierarchical TiO2 nanostructure for highly efficient pollutant removal
Authors: Xu Shiping , Gao Yuan , Sun Xiang , Yue Min , Yue Qinyan , Gao Baoyu
Published: October 2016

The facile one-pot synthesized carbon incorporated 3D hierarchical TiO2 nanostructures simultaneously possessed superior adsorption capability and photocatalytic activity towards pollutants.
Enhanced photoelectrical performance of chemically processed SnS2 nanoplates
Authors: Kumar G. Mohan , Xiao Fu , Ilanchezhiyan P. , Yuldashev Sh. , Kang T. W.
Published: October 2016

Photo electrical performances of the heterojunction diodes fabricated using chemically processed SnS2 nanoplates has been investigated.
Semi-aromatic polyamides containing methylene and thioether units: synthesis and membrane properties
Authors: Zhang Gang , Cao Su-Jiao , Ren Hao-Hao , Wang Xiao-Jun , Long Sheng-Ru , Yang Jie
Published: October 2016

The membranes of the resultant semi-aromatic polyamides showed good corrosion resistance, mechanical and thermal properties.
Pluronic stabilized Fe3O4 magnetic nanoparticles for intracellular delivery of curcumin
Authors: Barick K. C. , Ekta Ekta , Gawali Santosh L. , Sarkar Avipsha , Kunwar A. , Priyadarsini K. I. , Hassan P. A.
Published: October 2016

Water-dispersible Pluronic stabilized Fe3O4 magnetic nanoparticles were developed for intracellular delivery of hydrophobic anticancer drug.
CuI-catalyzed amination of Tröger's base halides: a convenient method for synthesis of unsymmetrical Tröger's bases
Authors: Reddy Manda Bhaskar , Reddy Potuganti Gal , Shailaja Myadaraboina , Manjula Alla , Rao Tadikamalla Prabhakar
Published: October 2016

A convenient and efficient Ullmann type copper catalyzed amination method has been developed for direct amination of halogen substituted Tröger's base analogues.
Synthesis and characterization of vinyl ester/inorganic layered material nanocomposites
Authors: Tsai Tsung-Yen , Bunekar Naveen , Yen Chein-Hsiang , Lin Yu-Bing
Published: October 2016

We present the osmotic swelling method for in situ free radical polymerization of well dispersed VE nanocomposites, which are expected to effectively help the development of wind blades.
Synthesis and characterization of two novel second-order nonlinear optical chromophores based on julolidine donors with excellent electro-optic activity
Authors: Zhang Hua , Huo Fuyang , Liu Fenggang , Chen Zhuo , Liu Jialei , Bo Shuhui , Zhen Zhen , Qiu Ling
Published: October 2016

Second order NLO chromophores with julolidine donor.
Molecular dynamics simulation elucidates the preferential binding affinity of sodium and tetramethylammonium ions for tetrameric Nafion unit under aqueous conditions
Authors: Ghosh Soumadwip , Chakrabarti Rajarshi
Published: October 2016

Preferential binding interaction of sodium and tetramethylammonium cations with Nafion pendant and backbone sites respectively.
Nanoscale topography, semiconductor polarity and surface functionalization: additive and cooperative effects on PC12 cell behavior
Authors: Snyder Patrick J. , Kirste Ronny , Collazo Ramon , Ivanisevic Albena
Published: October 2016

This work compares the behavior of PC12 cells on planar and patterned III-nitride materials with nanostructured topographies.
A simple and efficient in situ generated ruthenium catalyst for chemoselective transfer hydrogenation of nitroarenes: kinetic and mechanistic studies and comparison with iridium systems
Authors: Paul Bhaskar , Chakrabarti Kaushik , Shee Sujan , Maji Milan , Mishra Anju , Kundu Sabuj
Published: October 2016

A convenient and highly efficient in situ generated Ru(ii) system for synthesizing functionalized amines and mechanistic studies and comparison with iridium systems is presented.
Facile fabrication of robust superhydrophobic surfaces: comparative investigation
Authors: Bär Robin M. , Widmaier Simon , Levkin Pavel A.
Published: October 2016

Comparison of eight simple but robust superhydrophobic coatings in a wide space of parameters, helpful for planning correct experiments.
Study on Fe–Co alloy role over RANEY® Fe–Co bimetallic catalysts in Fischer–Tropsch synthesis
Authors: Zhai Yongbiao , Xue Yingying , Chen Zheng , Chen Min , Wang Buhuan , Chen Jiangang
Published: October 2016

Supersaturated R-Fe0.2Co0.8 and R-Fe0.1Co0.9 catalysts exhibited the best CO conversion and higher C5+ selectivity.
Semiconducting end-perfluorinated P3HT–fullerenic hybrids as potential additives for P3HT/IC70BA blends
Authors: Kakogianni S. , Lebedeva M. A. , Paloumbis G. , Andreopoulou A. K. , Porfyrakis K. , Kallitsis J. K.
Published: October 2016

Hybrid materials based on polythiophene–fullerene species covalently attached through aziridine bridges are presented, as potential stabilizers of P3HT:IC70BA active layers for BHJ devices.
Synthesis and optoelectronic properties of reduced graphene oxide/InP quantum dot hybrids
Authors: Jiang Guohua , Su Yanjie , Li Ming , Hu Jing , Zhao Bo , Yang Zhi , Wei Hao
Published: October 2016

The rGO/InP QD hybrids have firstly been synthesized using a hot-injection method, which exhibit good photoelectric response and efficient electron transfer from InP QDs to rGO nanosheets.
Facile hydrothermal synthesis and multicolor-tunable luminescence of YPO4:Ln3+ (Ln = Eu, Tb)
Authors: Xiong Hailong , Dong Jianchao , Yang Junfeng , Liu Yali , Song Hongbo , Gan Shucai
Published: October 2016

This work investigates a novel facile hydrothermal conversion method for the synthesis of uniform cuboid YPO4 and obtains multicolor emissions in YPO4:Tb3+, Eu3+ samples, and the energy transfer efficiency reachs about 94.30%.
A universal surface enhanced Raman spectroscopy (SERS)-active graphene cathode for lithium–air batteries
Authors: Liu Kewei , Yu Zitian , Zhu Xiaowen , Zhang Shuo , Zou Feng , Zhu Yu
Published: October 2016

A uniform SERS-active graphene electrode was used in lithium–oxygen batteries.
Ag-Functionalized macro-/mesoporous AZO synthesized by solution combustion for VOCs gas sensing application
Authors: Xing Xinxin , Li Yuxiu , Deng Dongyang , Chen Nan , Liu Xu , Xiao Xuechun , Wang Yude
Published: October 2016

The aim of this paper is to develop easily manufactured and highly sensitive gas sensors for VOCs (volatile organic compounds) detection.
One-step lipase-catalysed preparation of eslicarbazepine
Authors: El-Behairy M. F. , Sundby E.
Published: October 2016

The antiepileptic eslicarbazepine (S-licarbazepine) has been prepared in one step from its racemic formRS-licarbazepinevialipase catalysed kinetic resolution.
Design and fabrication of graphene fibers based on intermolecular forces and charge properties in a novel acidic system
Authors: Zhang Zhaofa , Zhang Desuo , Lin Hong , Chen Yuyue
Published: October 2016

This paper describes a new strategy of fabricating macroscopic graphene oxide fibers based on intermolecular forces and their charge properties in a new acidic coagulation system. This work extended the methods for preparation of graphene fibers.
A new microfluidic approach for the one-step capture, amplification and label-free quantification of bacteria from raw samples
Authors: Pereiro Iago , Bendali Amel , Tabnaoui Sanae , Alexandre Lucile , Srbova Jana , Bilkova Zuzana , Deegan Shane , Joshi Lokesh , Viovy Jean-Louis , Malaquin Laurent , Dupuy Bruno , Descroix Stéphanie
Published: October 2016

A microfluidic fluidized bed composed of antibody-grafted magnetic beads for the fast visual detection of bacteria by in situ expansion phenomena.
Pharmaceutical polymorph control in a drug-mimetic supramolecular gel
Authors: Foster Jonathan A. , Damodaran Krishna K. , Maurin Antoine , Day Graeme M. , Thompson Hugh P. G. , Cameron Gary J. , Bernal Jenifer Cuesta , Steed Jonathan W.
Published: October 2016

A supramolecular gel designed to chemically mimic the structure of a pharmaceutical compound controls the polymorphic outcome of the crystallization of the substrate.
Hierarchical Zn3V3O8/C composite microspheres assembled from unique porous hollow nanoplates with superior lithium storage capability
Authors: Bie Changfeng , Pei Jian , Chen Gang , Zhang Qiang , Sun Jingxue , Yu Yaoguang , Chen Dahong
Published: October 2016

Unique hollow nanoplate-assembled 3D Zn3V3O8/C composite microspheres fabricated via PVP assisted heterogeneous contraction effect exhibit superior performance as anode materials for lithium-ion batteries.
Constructing water-resistant CH3NH3PbI3perovskite films via coordination interaction
Authors: Li Bo , Fei Chengbin , Zheng Kaibo , Qu Xuanhui , Pullerits Tönu , Cao Guozhong , Tian Jianjun
Published: October 2016

2-aminoethanethiol in perovskite films improves the intrinsic water-resistance, and the films can retain the MAPbI3perovskite crystal structure when immersed in water for a long time (>10 minutes).
A thin-film silicon based photocathode with a hydrogen doped TiO2 protection layer for solar hydrogen evolution
Authors: Liang Junhui , Tan Hairen , Liu Min , Liu Bofei , Wang Ning , Zhang Qixing , Zhao Ying , Smets Arno H. M. , Zeman Miro , Zhang Xiaodan
Published: October 2016

There is a trade-off relationship between activity and stability in silicon based monolithic photovoltaic electrochemical (PV–EC) systems, especially when a thick TiO2 protection layer (preferred to enhance the chemical stability in the electrolyte) is used.
Decorating geometry- and size-controlled sub-20 nm Pd nanocubes onto 2D TiO2 nanosheets for simultaneous H2 evolution and 1,1-diethoxyethane production
Authors: Weng Bo , Quan Quan , Xu Yi-Jun
Published: October 2016

The morphological characteristics of metal play a pivotal role in affecting the activity of metal–semiconductor composite photocatalysts for solar energy conversion.
Metallic Ni3N nanosheets with exposed active surface sites for efficient hydrogen evolution
Authors: Gao Daqiang , Zhang Jingyan , Wang Tongtong , Xiao Wen , Tao Kun , Xue Desheng , Ding Jun
Published: October 2016

Atomically thin metallic Ni3N nanosheets fabricated as the hydrogen evolution cathode exhibit remarkable HER activity close to that of a commercial Pt/C electrode. The Ni atoms accompanied by surrounding N atoms on the N–Ni surface demonstrate a small ΔGH* of 0.065 eV due to the Ni–N co-effect, and thus act as the most active HER sites.
Regulation of the growth, morphology, mechanical properties and biocompatibility of natural polysaccharide-based multilayers by Hofmeister anions
Authors: Andreeva Tonya D. , Hartmann Hanna , Taneva Stefka G. , Krastev Rumen
Published: October 2016

Herein the optimization of the physicochemical properties and surface biocompatibility of polyelectrolyte multilayers of the natural, biocompatible and biodegradable, linear polysaccharides hyaluronan and chitosan by Hofmeister anions was systematically investigated.
Spheroid culture of primary hepatocytes with short fibers as a predictable in vitro model for drug screening
Authors: Wei Jiaojun , Lu Jinfu , Liu Yaowen , Yan Shili , Li Xiaohong
Published: October 2016

Short fibers are utilized as scaffolds for generation of size-controlled hepatocyte spheroids, exhibiting an efficient in vitro model for determining drug metabolism.
Triple-responsive inorganic–organic hybrid microcapsules as a biocompatible smart platform for the delivery of small molecules
Authors: Timin Alexander S. , Muslimov Albert R. , Lepik Kirill V. , Saprykina Natalia N. , Sergeev Vladislav S. , Afanasyev Boris V. , Vilesov Alexander D. , Sukhorukov Gleb B.
Published: October 2016

We designed novel hybrid inorganic/organic capsules with unique physicochemical features enabling multimodal triggering.
Developing Mn-doped lead sulfide quantum dots for MRI labels
Authors: Turyanska Lyudmila , Moro Fabrizio , Patanè Amalia , Barr James , Köckenberger Walter , Taylor Alexander , Faas Henryk M. , Fowler Maxine , Wigmore Peter , Trueman Rebecca C. , Williams Huw E. L. , Thomas Neil R.
Published: October 2016

Magnetic interactions of Mn2+ ions in lead sulfide (PbS) nanocrystals with protons in water are probed by NMR and MRI.
Nanohybrids of RGO nanosheets and 2-dimensional porous Co3O4 nanoflakes working as highly efficient counter electrodes for dye-sensitized solar cells
Authors: Du Feng , Zuo Xueqin , Yang Qun , Li Guang , Ding Zongling , Wu Mingzai , Ma Yongqing , Zhu Kerong
Published: October 2016

In this paper, nanohybrids (Co3O4@RGO) of 2-dimensional (2D) porous Co3O4 nanoflakes anchored on reduced graphene oxide nanosheets have been fabricated by a facile hydrothermal reduction process.