bluuebunny/crossref_metadata_2025 huggingface dataset:
Resistance and Biofilm Production Profile of Potential Pathogens Isolated from Kpètè Kpètè Used to Produce Traditional Fermented Beer in Benin
Authors: N'Tcha Christine , Sina Haziz , Bourobou Dyana Ndiade , Hoteyi Ismaël M. S. , Boya Bawa , Agnimonhan Raul , Mavoungou Jacques François , Adjanohoun Adolphe , Babalola Olubukola Oluranti , Baba-Moussa Lamine
Published: May 2023

This study aimed to determine the pathogenicity of the bacteria isolated and characterized from the kpètè kpètè used to produce two fermented beers in Benin. Species were identified by specific biochemical tests such as catalase, coagulase, and API 20 E. Antibiotic sensitivity was tested according to the French Society of Microbiology Antibiogram Committee. The crystal violet microplate technique and conventional PCR evaluated biofilm production to identify genes encoding virulence and macrolide resistance. Our data shows that Kpètè Kpètè used to produce beers are contaminated by Enterobacteriaceae species (Klebsiella terrigena, Enterobacter aerogens, Providencia rettgeri, Chryseomonas luteola, Serratia rubidae, and Enterobacter cloacae) and Staphylococcus spp. These multidrug-resistant strains can produce biofilms with a strong predominance of Enterobacter aerogens, Klebsiella terrigena (100%), and Staphylococcus spp (60%). Enterobacter cloacae (4%) and Coagulase negative Staphylococcus (5.55%) harbor the macrolide resistance gene. For other strains, these genes were not detected. Foods contaminated with bacteria resistant to antibiotics and carrying a virulence gene could constitute a potential public health problem. There is a need to increase awareness campaigns on hygiene rules in preparing and selling these traditional beers.
Okra Yield Increased by Bat Guano beyond Its Nutrient Supply
Authors: Dimande Paulo , Arrobas Margarida , Rodrigues Manuel Ângelo
Published: May 2023

The difficulty in obtaining commercial fertilizers by smallholder farmers in sub-Saharan Africa makes it very important to optimize the use of local organic resources. In VilanKulo, Mozambique, a study was carried out on okra (Abelmoschus esculentus) over two growing seasons in a haplic Lixisol, a loamy-sand textured soil, applying both bat guano and biochar prepared by an artisanal process. Bat guano was applied at two rates (5 and 10 t ha−1), one month and just before sowing. Biochar was also used at two rates (5 and 10 t ha−1) applied close to sowing. Mixtures of biochar and guano at two rates (1 and 4 t ha−1, and 2 and 8 t ha−1, respectively) were also used along with a non-fertilized control. Field trials were arranged in a completely randomized design with three replicates. The treatments receiving high rates of guano tended to show significantly higher fruit yields (> 10 t ha−1, being the two-year average) in comparison to the control, which showed the lowest average okra fruit yield (6.21 t ha−1). In guano treatments, the apparent recovery by okra of some important nutrients, such as nitrogen (N), was greater than the amount of nutrient contained in the guano itself. This result, together with many others related to tissue nutrient concentration, soil properties and residual fertilizing value in guano plots, indicates a strong mineralization of guano during the growing season, probably due to its low carbon (C)/N ratio and favourable environmental conditions for the mineralization process, such as high temperature and well-aerated soil. The result also suggests some kind of manuring effect, i.e., a fertilizing effect of guano beyond what can be explained by the nutrient supply. The use of biochar increased total organic C in the soil and cation exchange capacity (CEC) compared to the control, but did not affect variables related to plant performance, such as tissue nutrient concentration or plant growth and yield.
Preventive Epigenetic Mechanisms of Functional Foods for Type 2 Diabetes
Authors: Bilyaminu Abubakar , Usman Dawoud , Sanusi Kamaldeen Olalekan , Azmi Nur Hanisah , Imam Mustapha Umar
Published: May 2023

Type 2 Diabetes (T2D) is a growing global health problem that requires new and effective prevention and management strategies. Recent research has highlighted the role of epigenetic changes in the development and progression of T2D, and the potential of functional foods as complementary therapy for the disease. This review aims to provide an overview of the current state of knowledge on the preventive epigenetic mechanisms of functional foods in T2D. We provide background information on T2D and its current treatment approaches, an explanation of the concept of epigenetics, and an overview of the different functional foods with demonstrated preventive epigenetic effects in T2D. We also discuss the epigenetic mechanisms by which these functional foods prevent or manage T2D and the studies that have investigated their preventive epigenetic effects. In addition, we revisit works on the beneficial influence of functional foods against the programming and complications of parentally-triggered offspring diabetes. We also postulate, albeit based on the scarce data, that epigenetic inheritance mechanistically mediates the impacts of functional nutrition against the metabolic risk of diabetes in the offspring. Finally, our review highlights the importance of considering the preventive epigenetic mechanisms of functional foods as a potential avenue for the development of new prevention and management strategies for T2D.
Potential for Land Application of Biosolids-Derived Biochar in Australia: A Review
Authors: Sinha Payel , Marchuk Serhiy , Harris Peter , Antille Diogenes L. , McCabe Bernadette K.
Published: May 2023

Thermal treatment in Australia is gaining interest due to legislative changes, waste reduction goals, and the need to address contaminants risks in biosolids used for agriculture. The resulting biochar product has the potential to be beneficially recycled as a soil amendment. On-farm management practices were reviewed to identify barriers that need to be overcome to increase recycling and examine the role of pyrolysis and gasification in effectively improving the quality and safety of biochar. Key findings revealed: (1) thermal treatment can effectively eliminate persistent organic pollutants, microplastics and pathogens, and (2) more than 90% of the total heavy metals content in biosolids become immobilized when these are converted to biochar, thus reducing their bioavailability following land application. While reported research on the short-term effects of biosolids-derived biochar suggested promising agronomic results, there is dearth of information on long-term effects. Other knowledge gaps include optimisation of land application rates, understanding of rate of breakdown and fate of contaminants in soil and water, heavy metal mobility in soil and bioaccumulation or transfer to the food chain. Improved understanding of nutrients and contaminants dynamics in soils receiving biosolids-derived biochar is a pre-requisite for their safe use in Australian agriculture, and therefore it is highlighted as priority area for future research.
All-Optical, Air-Coupled Ultrasonic Detection of Low-pressure Gas Leaks and Observation of Jet Tones in the MHz Range
Authors: Scheuer Kyle G. , DeCorby Ray G.
Published: May 2023

We used an ultrasensitive, broadband optomechanical ultrasound sensor to study the acoustic signals produced by pressurized nitrogen escaping from a variety of small syringes. Harmonically related jet tones extending into the MHz region were observed for a certain range of flow (i.e., Reynolds number), in qualitative agreement with historical studies on gas jets emitted from pipes/orifices of much larger dimensions. For higher turbulent flow rates, we observed broadband ultrasonic emission in the ~ 0 – 5 MHz range, likely limited on the upper end by attenuation in air. These observations are made possible by the broadband, ultrasensitive response (for air-coupled ultrasound) of our optomechanical devices. Aside from their theoretical interest, our results could have practical implications for the non-contact monitoring and detection of early-stage leaks in pressured fluid systems.
Antioxidants Prevent Iron Accumulation and Lipid Peroxidation, but do not Correct Autophagy Dysfunction or Mitochondrial Bioenergetics in Cellular Models of BPAN
Authors: Suárez-Carrillo Alejandra , Álvarez-Córdoba Mónica , Romero-González Ana , Talaverón-Rey Marta , Povea-Cabello Suleva , Cilleros-Holgado Paula , Piñero-Pérez Rocío , Reche-López Diana , Gómez-Fernández David , Romero-Domínguez José M. , Munuera-Cabeza Manuel , Díaz Antonio , Gonzalez-Granero Susana , García-Verdugo José M. , Sánchez-Alcázar And José A.
Published: May 2023

Neurodegeneration with brain iron accumulation (NBIA) is a group of rare neurogenetic dis-orders frequently associated with iron accumulation in the basal nuclei of the brain. Among NBIA subtypes, β -propeller protein-associated neurodegeneration (BPAN) is associated with mutations in the autophagy gene WDR45.
The aim of this study was to demonstrate autophagic defects and secondary pathological con-sequences in cellular models derived from two patient harboring WDR45 mutations.
Both protein and mRNA expression levels of WDR45 were decreased in patient-derived fibro-blasts. In addition, the increase of LC3B upon treatments with autophagy inducers or inhibitors was lower in mutant cells compared to control cells, suggesting decreased autophagosome formation and impaired autophagic flux. Transmission electron microscopy (TEM) analysis showed mitochondrial vacuolization associated with accumulation of lipofuscin-like aggregates containing undegraded material. Autophagy dysregulation was also associated with iron ac-cumulation and lipid peroxidation. In addition, mutant fibroblasts showed altered mitochon-drial bioenergetics. Antioxidants such as pantothenate, vitamin E and α-lipoic prevented lipid peroxidation and iron accumulation. However, antioxidants were not able to correct the ex-pression levels of WDR45 neither the autophagy defect nor cell bioenergetics.
Our study demonstrated that WDR45 mutations in BPAN cellular models impaired autophagy, iron metabolism and cell bioenergetics. Antioxidant partially improved cell physiopathology, however autophagy and cell bioenergetics remained affected.
Effectiveness of Adjunctive Hyaluronic Acid Application in Surgical Treatment of Gingival Recession Sites: A Systematic Scoping Review
Authors: Manfredini Mattia , Beretta Mario , Maiorana Carlo , Tandurella Marco , Salina Federica Euegnia , Poli Pier Paolo
Published: May 2023

The aim of this systematic scoping review was to provide scientific evidence on the efficacy and methods of application of hyaluronic acid in the coverage of gingival recessions in terms of recession depth (RD) reduction, clinical attachment level (CAL) gain, probing depth (PD). An electronic search of the literature on the main databases was conducted. Initially, 405 articles were identified. Finally, 4 studies were included after the review process. It was not possible to perform a meta-analysis of the articles selected because of the differences among the surgical treatments and commercial formulations and compositions of hyaluronic acid. Both randomized controlled trials in this research examined Recession Type 1 gingival treated with coronally advanced flap. Recessions were treated with either modified coronally advanced tunnel or laterally closed tunnel combined with subepithelial connective tissue graft and hyaluronic acid (HA) in all case series. The studies analyzed no significant variation was found in PD variable. The results of RD reduction are in accordance with the literature. Modifications of CAL are connected to variations of RD. HA seems to improve the clinical outcomes of the described surgical treatment.
Characteristics Associated with Major Complications and Refractory Course in Patients with Osteomyelitis of the Jaw: Clinical, Radiological, and Bacteriological Features of 54 Patients
Authors: FENELON MATHILDE , Gernandt Steven , Aymon Romain , SCOLOZZI PAOLO
Published: May 2023

Despite improved knowledge regarding diagnosis and treatment of osteomyelitis of the jaw (OMJ), it remains a clinical challenge for oral and maxillofacial surgeons. This study aimed to identify risk factors associated with severe forms of OMJ, i.e. related to the occurrence of major complications or the refractory course of the disease. A retrospective study was performed based on the medical records of all patients diagnosed with OMJ from the past 20 years. Collected data included demographic information, medical and dental history, clinical, radiological, and bacterial findings as well as treatment modalities. The main outcome variables were the onset of major complications and treatment results. Fifty-four patients were included. Our results showed that alcohol and smoking habits, as well as malnutrition, were significantly associated with the occurrence of major complications. We also established that dental implant–induced OMJ should be considered as an aggressive subtype of OMJ. Finally, clinical bone exposure was significantly associated with unfavorable outcomes, whereas dental causes or radiological evidence of periosteal reaction were predictive of successful outcomes. Identifying such factors could be useful in preventing serious complication and informing patients about the refractory course of the disease based on the presence of these factors.
Culture, Mindset and Functionality in Regional Organisations – A Study on ASEAN and the European Union.
Authors: Rautakivi Tuomo , Yolles Maurice
Published: May 2023

Regional organisations (ROs) are important in that they can enable states in their regions to pros-per and develop for improvement. Interest here lies in the European Union (EU) and the Associa-tion of South East Asian Nations (ASEAN). Their political development involves complex process-es for collective actions involving ingroup member RO states. To explore development, we firstly examine the rise of both the EU and ASEAN. The literature gives some attention to the behaviour-alist political approach to explain developmental differences using social organisation theory, often in terms of the Gemeinschaft-Gesellschaft paradigm of Tönnies. However, here we adopt a social psychology approach that distinguishes between operative structure (which directly determines behaviour), and substructure (housing normative personality deemed to be responsible for behav-ioural imperatives). This enables a relationship to be made between the Tönnies paradigm and the Collectivism-Individualism paradigm of Triandis. The theoretical approach adopted involves a complex adaptive systems model deriving from metacybernetics, and this also delivers Mindset Agency Theory as a qualitative methodology. Consistent with the general view, it is shown that the EU is more or less a coherent rational organisation, while ASEAN is more idealistic delivering pragmatic paradox. In particular, ASEAN is frequently descried as an organisation with contra-dictions, and for this reason its pathologies are explored in some detail
Proving Maximal Linear Loose Tangle as a Linear Tangle
Authors: Fujita Takaaki
Published: May 2023

Linear-width is a well-regarded width parameter in graph theory. The constructs of linear loose tangle and linear tangle present obstacles to attaining linear-width. In this succinct paper, our primary focus will be the exploration of maximal linear loose tangles.
Head to Head Comparison of 18F-Fluorocholine and Imaging of Prostate-Specific Membrane Antigen, using 18F-DCFPyL PET/CT, in Patients with Biochemical Recurrence of Prostate Cancer: A Review
Authors: Garcia Zoghby Laura , Lucas Lucas Cristina , Amo-Salas Mariano , Soriano Castrejon Angel Maria , Garcia Vicente Ana Maria
Published: May 2023

Purpose
To analyse diagnostic and therapeutic impact of molecular imaging TNM (miTNM) stage obtained with 18F-DCFPyL versus 18F-Fluorocholine in head to head comparison in biochemical recurrence (BCR) prostate cancer (PCa).
Material and methods
Patients with BCR PCa after radical treatment with previous 18F-Fluorocholine-PET/CT (negative or oligometastatic disease) were derived to 18F-DCFPyL-PET/CT. Patients were classified attending to: grade group, EAU classification, PSA, PSA doubling time (PSAdt) and PSA velocity (PSAvel).
The overall detection rate (DR) and miTNM stage according to PROMISE criteria were assessed for both radiotracers and also correlation (Kappa). The influence of PSA and kinetics on both PET/CT (DR and miTNM) and predictive value of unfavourable kinetics on miTNM were determined.
Cut-off PSA, PSAdt and PSAvel values able to predict PET/CT results were determined. Change in miTNM and treatment derived of 18F-DCFPyL information with respect to 18F-Fluorocholine was also evaluated.
Results
We studied 138 patients. 18F-DCFPyL showed a higher DR than 18F-Fluorocholine (64.5% vs 33.3%). 18F-DCFPyL and 18F-Fluorocholine detected T in 33.3% versus 19.6%, N in 27.5% versus 13.8%, M in 30.4% versus 8.7%. Both tracers DR showed significant associations with PSA and PSAvel. Significant association was only found between miTNM and PSA on 18F-Fluorocholine-PET/CT (p=0.033). For 18F-Fluorocholine and 18F-DCFPyL PET/CT a PSAdt cut-off of 4.09 and 5.59 months, respectively, were able to predict M stage. 18F-DCFPyL changed therapeutic management in 40/138 patients.
Conclusion
18F-DCFPyL provides a higher DR and superior miTNM staging than 18F-Fluorocholine in restaging BCR, especially with high PSA and unfavourable PSA kinetics, showing a fair agreement to 18F-Fluorocholine.
Moderation of Clean Energy Innovation in the Relationship between the Carbon Footprint and Profits in CO₂e-Intensive Firms: A Quantitative Longitudinal Study
Authors: Porles Ochoa Francisco , Guevara Ruben
Published: May 2023

The purpose of this research was to analyze the moderating effect of clean energy innovation on the relationship between corporate carbon footprint and corporate profits in those industrial sectors associated with high demand for fossil fuels in which it is "hard to abate" CO₂e emissions. It used a longitudinal research design, in particular a panel study under a structural equation modeling (SEM) approach, based on partial least squares. For the longitudinal moderation analysis, this research employed the Bayesian method by defining a multiple-indicator latent growth curve model (B-LGC model). A global sample was used consisting of 7,827 firm-year observations between 2015 and 2021 corresponding to 167 international firms. The results revealed a very significant impact of the corporate carbon footprint on corporate profits. Likewise, the results showed that innovations in clean energy, when measured as the consumption of renewable energy, positively moderates the relationship between the greenhouse gas emissions from the value chain associated with Scope 3 of the Greenhouse Gas (GHG) Protocol, and the gross profit margin obtained. Besides the academic contribution represented by the moderating effect of clean energy innovation, these findings imply that a more detailed understanding of the emissions of the entire value chain (Scope 3 CO₂e) by executives and managers of high emitting CO₂e companies represents an effective mechanism to obtain higher profits, create competitive advantages and, at the same time, achieve a net zero emissions strategy. More importantly, public policy makers will be able to use these results to revise CO₂e-related policies paying more attention to the Scope 3 CO₂e emissions produced by these companies, to formulate regulatory and control mechanisms that stimulate clean energy innovation.
Real-World Clinical Characterization of Polycythemia Vera Patients From a Prospective Registry in Portugal: Is Resistance to Hydroxyurea a Reality?
Authors: Sarmento Maria , Duarte Marta , Ponte Sandra , Sanchez Juan , Roriz Diana , Fernandes Laura , Silva Maria José Monteiro , Pacheco Judite , Ferreira Gisela , Freitas Jorge , Costa Inês , Brás Daniel
Published: May 2023

Patients with polycythemia vera (PV) are at increased risk of thrombosis and hemorrhages. Although hydroxyurea (HU) has been the frontline therapy for patients at high-risk of vascular complications, about 25% of patients develop resistance/intolerance to this therapy. The aim of this non-interventional, multicenter cohort study was to understand the clinical characteristics and HU treatment response of Portuguese PV patients. HU resistance/intolerance was defined according to adjusted European LeukemiaNet (ELN) criteria. 134 PV patients with a mean disease duration of 4.8±5.0 years were included and followed up for 2 years. At baseline, most patients were ≥60 years old (83.2%), at high risk for thrombotic events (87.2%), and receiving HU therapy (79.1%). A total of 10 thrombotic events and 8 hemorrhagic events were reported, resulting in a 5-year probability of thrombo-hemorrhagic events of 17.2%. Hematocrit (p=0.007), hemoglobin (p=0.012) and MPN10 symptom score (12.0±11.6 vs 10.3±9.1; p=0.041) decreased significantly at the 24-month visit compared to baseline. Overall, 75.9% of patients met at least one of the adjusted ELN criteria for HU resistance. 14.4% of patients remained on HU throughout the study. The results from this real-world study may help identify the subset of patients at higher risk of disease sequelae who may benefit from earlier second-line treatment.
Dietary Manipulation of Amino Acids for Cancer Therapy
Authors: Jiménez-Alonso Julio José , López-Lázaro Miguel
Published: May 2023

Cancer cells cannot proliferate and survive unless they obtain sufficient levels of the 20 proteinogenic amino acids (AAs). Unlike normal cells, cancer cells have genetic and metabolic alterations that may limit their capacity to obtain adequate levels of the 20 AAs under challenging metabolic environments. However, since normal diets provide all AAs at relatively constant levels and ratios, these potentially lethal genetic and metabolic defects are eventually harmless to cancer cells. If we temporarily replace the normal diet of cancer patients with artificial diets in which the levels of specific AAs are manipulated, cancer cells may be unable to proliferate and survive. This article reviews in vivo studies that have evaluated the antitumor activity of diets restricted or supplemented with the 20 proteinogenic AAs, individually and in combinations. It also reviews our recent studies that show that manipulating the levels of several AAs simultaneously can lead to marked survival improvements in mice with metastatic cancers.
An Overview of Catalytic Carbonylative Double Cyclization Reactions
Authors: Gabriele Bartolo , Mancuso Raffaella , Della Ca' Nicola , Veltri Lucia , Ziccarelli Ida
Published: May 2023

This short review is aimed at giving an overview of catalytic carbonylative double cyclization reactions, which are processes in which suitable organic substrates and carbon monoxide are sequentially activated by a promoting catalyst to afford the formation of two new cycles with concomitant incorporation of carbon monoxide as a carbonyl function into the final product. Paradigmatic examples of this powerful synthetic methodology, which allows the one-step synthesis of complex molecular architectures from simple building blocks using the simplest and readily available C-1 unit (CO) are illustrated and discussed. The review is divided into five sections: 1) Introduction; 2) Functionalized Olefinic Substrates; 3) Functionalized Acetylenic Substrates; 4) Functionalized Halides; 5) Conclusions and Future Perspectives.
A Proof of Collatz Conjecture
Authors: Qingxue HUANG
Published: May 2023

In 1937,German mathematician L.Collatz proposed a conjeture:for any positive integer,if it is even,divide it by 2;if it is odd,multiply it by 3 and 1 to get an even number;keep going on and on, the final result is 1.This paper gives a sequence classification of odd numbers,and gives 1-1 mapping of odd numbers and odd number sequences,and uses these results to give a proof of this conjecture.
Estimation of the Restoration Period of the Water Supply System in Lima, Peru, After a Scenario Earthquake
Authors: Maruyama Yoshihisa , Ichimoto Ryo , Nojima Nobuoto , Inocente Italo , Gallardo Jorge , Quiroz Luis
Published: May 2023

The restoration period of the water supply system in Lima, Peru, after a scenario earthquake was estimated in this study. To achieve the objective, the probabilistic assessment model for post-earthquake residual capacity of the utility lifeline system initially proposed by Nojima and Sugito (2005) and revised by following related studies was employed. The dataset of water distribution pipelines was provided by Potable Water and Sewer System Service in Lima, Peru (SEDAPAL), and the spatial distribution of ground motion with a moment magnitude of 8.6 was considered as a scenario earthquake in this study. The water disruption was anticipated to continue for approximately one month in certain districts of Lima, Peru. The estimated smallest water supplying ratio was 21.1% in Villa El Salvador after the scenario earthquake.
The Importance of Family and Community Approach in Reducing the Risk Faced by the Elderly During the COVID-19 Pandemic
Authors: Hidayati Deny , Widayatun  , Situmorang Augustina
Published: May 2023

COVID-19, spreads very quickly and became a global pandemic in a short time, is not only life-threatening but also disrupts people’s lives, especially the elderly who are very vulnerable to being exposed to the coronavirus. The number of Indonesian elderly people is constantly increasing, reaching around 29 million in 2021. Almost half of them have socio-demographic vulnerability, high morbidity, and limited economic conditions. This paper discusses the importance of reducing the impact and risk that elderly people face in dealing with the COVID-19 pandemic with a family and community approach. During the pandemic, the elderly people in the research location confront many challenges, such as accessing health facilities and services, providing basic daily needs, and engaging in social interaction, which are limited due to the government’s social restrictions. The health vulnerabilities and risks of the elderly are therefore getting higher, as indicated by the large number of them exposed to and dying due to COVID-19. The economic vulnerability and financial dependence of some elderly on their families also increase. In these difficult conditions, their families and residential communities provide enormous support and positively influence the knowledge, awareness, and behavior of the elderly regarding the COVID-19 pandemic. This research relies heavily on primary data collection using qualitative methods through in-depth interviews with representatives of the elderly in the City of Bekasi, West Java. Data are also collected through a desk review of relevant books, articles, and documents.
PENGEMBANGAN ALAT PENILAIAN PRAKTIK RESERVATION CONVERSATION MENGGUNAKAN APLIKASI VE-RUBRIC DI SEKOLAH MENENGAH KEJURUAN AKOMODASI PERHOTELAN
Authors: Salsabila Salsabila , Rohaeni Neni , Jubaedah Yoyoh
Published: May 2023

Penelitian ini dilatarbelakangi oleh penggunaan alat penilaian di sekolah yang masih dilakukan secara konvensional (paper-based). Dalam perkembangan teknologi di dunia pendidikan yang berimplikasi pada pengembangan penilaian. Kondisi tersebut menunjukkan perlunya pengembangan rubrik penilaian berbasis digital. Penelitian ini bertujuan untuk mengembangkan alat penilaian praktik Reservation Conversation menggunakan VE. Rubric di Sekolah Menengah Kejuruan (SMK). Metode yang digunakan dalam melakukan penelitian ini adalah deskriptif dengan pendekatan ADDIE (Analysis, Design, Development, Implementation, and Evaluation). Teknik pengumpulan data dilakukan dengan observasi, wawancara, expert judgement, serta angket respon kepada guru mata pelajaran front office di SMK. Hasil validasi pengembangan alat penilaian adalah: (1) ahli penilaian menilai sangat layak dengan persentase sebesar (85,7%). (2) ahli materi menilai sangat layak dengan persentase sebesar (97,5%). Implementasi dilakukan dengan uji coba terbatas pada 6 orang peserta didik di SMK. Evaluasi diisi dengan kegiatan pengisian angket kuesioner usability respon guru terhadap implementasi yang  telah dilakukan, dengan hasil guru menilai layak dengan persentase (79,3 %). Berdasarkan hasil perolehan data menunjukkan bahwa alat penilaian praktik Reservation Conversation menggunakan VE. Rubric layak digunakan.
The Peran Teknologi dalam Menekan Biaya Alur Pendistribusian Barang
Authors: Khairunnisa Arandra Swari , Arif Hilmi , Faiza Salma Nur , Rizkyanfi Mochamad Whilky
Published: May 2023

Distribusi barang merupakan penyaluran barang sebagai kegiatan pemasaran suatu produk dari produsen hingga sampai ke konsumen secara tepat. Secara umum, masalah distribusi komoditas mengacu pada pemilihan rute jaringan distribusi untuk suatu produk dari berbagai sumber dengan pasokan terbatas ke beberapa tujuan dengan permintaan pasar yang melonjak tetapi dengan biaya transportasi serendah mungkin. Perusahaan memerlukan strategi yang unggul di era digitalisasi dengan menyesuaikan zaman yang didukung oleh perkembangan IT yang modern. Tujuan artikel ini untuk mengetahui peranan teknologi dalam menekan biaya dalam alur pendistribusian barang dan mengetahui beberapa strategi yang berguna untuk kepuasan konsumen dengan memenuhi harapan konsumen berupa harga yang relatif terjangkau. Metode studi yang digunakan berupa deskriptif dengan pendekatan kualitatif yang memfokuskan terhadap fenomena-fenomena atau sebuah kejadian. Penerapan E-SCM, pemasaran digital, dan penerapan e-commerce dapat meminimasi biaya pada alur pendistribusian barang yang dibuktikan oleh beberapa studi kasus yang diambil dari sumber jurnal-jurnal terdahulu.
Environmental-Based Tourism Village Modeling in Tasikmalaya District, West Java
Authors: Siti Fadjarajani  , Sunaedi Nedi , Erni Mulyanie  , Hilman Hakim Erwin
Published: May 2023

The tourism sector in Tasikmalaya Regency has very good potential to be developed towards an ecotourism-based tourism area. The objectives of this study were: to identify the level of fulfillment of the criteria for a tourist village in Santana Mekar Village, Tasikmalaya; and formulate the development and modeling of environmentally-based tourism villages. The research method used is a qualitative research method with a field survey. Analysis of the potential of the three tourist areas using SWOT analysis. Santana Mekar Village has tourism potential which can be divided into three categories, namely: natural tourism, educational tourism, and cultural tourism, based on these three potentials, Santanamekar village can be used as a model for eco-based tourism village and become leading tourism in Tasikmalaya Regency. The results of this study are expected to provide important information about tourism potential that can be developed and can be input for local governments in tourism development policies in Tasikmalaya Regency.
1876 Osmanlı-Sırp-Karadağ Savaşı'nda Osmanlı Ordusunda Gayrimüslim Gönüllüler
Authors: ÖZKAN Ayşe
Published: May 2023

Bu çalışmada 1876 Osmanlı- Sırp-Karadağ Savaşı’nda Osmanlı ordusunda yer alan gayrimüslim gönüllüler incelenmiştir. Öncelikle savaşın başlangıcı, Prens Milan’ın savaş beyannamesi ile Sırp ordusundaki Rus gönüllüler hakkında kısa bilgi verilmiştir. Sonrasında Osmanlı ordusunda 1870 tarihli Askerlik Kanunu’na göre gönüllülük kavramı açıklanmıştır. Nizamiye, redif ve müstahfız sınıflarının dışında gönüllü askerlerden oluşan orduya Müslümanların yanı sıra gayrimüslimler de asker yazılmak için başvuruda bulunmuşlardır.1877-1878 Osmanlı-Rus Savaşı’nda da ön planda olan Dimostini Efendi Hristiyanlardan asker yazarak savaşa göndermiş ve ödüllendirilmiştir. Osmanlı Devleti’nin kendi gayrimüslim tebaasının yanında yurtdışından da orduya gönüllü katılımlar olmuştur. Belçika’dan, Lehistan’dan ve Macaristan’dan gönüllüler Osmanlı ordusuna katılmak için başvuruda bulunmuşlardır. Özellikle Macarlar her şekilde Osmanlı Devleti’nin ve Türklerin yanında yer almışlar, maddi ve manevi her türlü yardımda bulunmuşlardır. Macaristan’dan siviller olduğu kadar subay ve erler de gönüllü olarak Osmanlı Devleti ordusuna katılmak istemişlerdir. Macar doktorlar ise ordunun yaralarını sarmak istemişlerdir.
Namık Kemal’in Siyasî Paradigmasında Meşveret Kavramı ve Meclis Düşüncesi
Authors: DEĞİRMENCİ Hakan
Published: May 2023

Demokrasi, Türk siyasi tarihinde yüz elli yıllık bir geçmişe sahiptir. Meşrutiyet’in az öncesinde başlayan demokrasi mücadelesi, Yeni Osmanlılar Cemiyeti’nin gayretiyle ortaya çıkmış ve “meclis” kavramıyla hayat bulmuştur. Bu dönemde ismi en çok öne çıkan kişi hiç kuşkusuz Namık Kemal olmuştur.
Namık Kemal, fıtratının ve yetişme şeklinin gereği olarak eleştirel düşünceye açık ve dışa dönük bir kişidir. Tercüme Odası’nda çalışmaya başlaması, burada Şinasi ile tanışması, Fransızca öğrenmesi ve Avrupa’yı görmesi itibariyle Batılı fikirlere ve yeniliklere açık yetişmiştir. Namık Kemal böylelikle mizacının getirdiği mücadele gücüyle birlikte daima yeni fikirler peşinde koşmuş, bir aydın sorumluluğu ile düşüncelerini idareyle ve halkla paylaşmıştır. Diğer taraftan gazetelerde ve edebî mahsullerinde işlediği fikirleri ile yaşadığı dönemden günümüze kadar uzanan bir çizgide Türk siyasal ve sosyal hayatına tesir etmiştir.
Namık Kemal, devlet yönetimiyle ilgili olarak “meşrutiyet”i savunmuştur. Meşrutiyet, padişahın altında bir meclisin varlığını öngören yönetim biçimidir. Osmanlı devlet yapısını ve çağın ruhunu göz önünde bulundurduğumuzda o günlerdeki meclis talebinin bugünkü demokrasinin nüvesi olduğunu çok net bir biçimde ifade edebiliriz. Çalışmamızda meşveret kavramı ve meclis düşüncesinin Namık Kemal’in fikir ve hareket dünyasındaki karşılığını aramaya çalışacağız.
Osmanlı Taşrasında Bir Seçkinin Yükselişi: İçelli Abdülmü’min Paşa [1650-1684]
Authors: KÖSE Ensar
Published: May 2023

Bu araştırmanı öznesi Abdülmü’min Paşa, İçel sancağına bağlı Zeyne kasabasında, köklü geçmişe sahip bir aileye mensuptur. Mahalli bir lider olarak, 1650’lerden itibaren adından söz ettirmeye başlamıştır. 1664’te mütesellim, 1673’te mukātaa voyvodası olmuştur. 1683’te II. Viyana seferine, İçel sancağı mutasarrıfı olarak katılmıştır. Kuşatma sonrasındaki savaşta Karaman Beylerbeyi hayatını kaybedince, Karaman eyaleti de Abdülmü’min Paşa’ya verilmiştir. Bundan bir yıl sonra 1684’te ise, Budin savunmasında şehit düşmüştür. İşte bu makalede, bir taşra seçkini olarak Abdülmü’min Paşa’nın yükselişi ve Osmanlı idari zümresine katılışı anlatılmaktadır. Osmanlı eyalet ve livalarındaki mansıpların, Enderun çıkışlı ağlar, paşalar ve paşa-zâdeler tarafından doldurulduğu bir devirde, yerelden birinin ortaya çıkarak askerî sınıfa katılması nadiren görülen bir durumdur. Bu yönüyle Abdülmü’min Paşa, Osmanlı taşra toplumunda âyan zümresinin doğuşu ve yükselişi bağlamında da ilginç bir örnektir. Onun yükseliş hikâyesi, mümkün olduğunca, devrin şartları ve merkezî hükümetin yapısındaki değişimlerle paralel şekilde verilmeye çalışılmıştır. Özellikle, sancakbeyi tevcihlerinin genel seyri, araştırma boyunca gözden uzak tutulmamıştır. Araştırmanın birincil kaynakları, büyük ölçüde Osmanlı arşivindeki defterler, belgeler ve tevcih kayıtlarından oluşmaktadır. Ayrıca Konya ve Karaman kadı sicillerinden de istifade edilmiştir. Keza dönemin Osmanlı kronikleri de yine birincil kaynaklarımızdandır.
Towards the acquisition of strategic competence in translator training
Authors: Gregorio Cano Ana
Published: May 2023

Unravelling the complex process of acquiring Translator Competence (TC) is a considerable challenge. Whilst TC has been considered fundamental to translator training, research, and training have often been limited to theoretical reflections, without including empirical input. In this proposal, we will try to fill a gap in the empirical studies that have been performed to date on TC and the analysis of its acquisition in real teaching practice. We offer the reader an in-depth review of key issues for the training of translators before presenting the empirical study. In the first part, we place the reader in the context in which the study is framed, dealing with basic concepts such as TC. This paper summarizes essential ideas before exploring the question of TC acquisition, and particularly into strategic competence (SC). In the second part, we describe the quantitative and qualitative methodology of the empirical study. The longitudinal study, presented, includes a group of 37 subjects, allowing greater depth in the analysis of the processes of the acquisition of SC. Finally, we present our conclusions. Our results shed light on key issues for the development of theory and practice to facilitate advances in the training of translators.
Sexo, amor y palabras
Authors: Ogea Pozo Maria del Mar , Botella Tejera Carla
Published: May 2023

Las series de adolescentes o teen series llevan ya años acompañándonos y representando escenas y situaciones con las que se identifican jóvenes y adolescentes. Sin embargo, además de identificarse con dichas escenas, también lo hacen con el léxico y expresiones que emplean sus protagonistas. De esta manera, recrean una especie de jerga juvenil que, entre otros temas de interés para sus receptores, cubre el de la relaciones sexuales y amorosas. Así, través de la traducción, estas series llegan distintos países y espectadores muy diversos. En el caso del doblaje, a pesar de partir de una oralidad prefabricada, los diálogos tienen que ser lo más naturales posibles para que resulten verosímiles para el público meta. Por eso, el léxico relacionado con las relaciones sexuales y amorosas en español deberá intentar producir en la nueva audiencia las mismas sensaciones provocadas a los de la versión original.

Este artículo estudia doce episodios de tres series de adolescentes de los últimos años (2019-2022) tanto en su versión original como en su versión doblada al español con el objetivo de analizar las dificultades de traducción de este tipo de léxico, su posible caducidad y censura recibida, para llegar a establecer una taxonomía propia de clasificación del léxico de las relaciones. Así, llegamos a la conclusión de que se da una cifra muy similar de términos de esta jerga en las series ambos idiomas, a pesar de darse algunas diferencias interesantes, pero que, en general, el doblaje de las tres permite una experiencia pareja a la que viven los espectadores de la versión original.
SÁNCHEZ-MOMPEÁN, Sofía. The Prosody of Dubbed Speech. Beyond the Character’s Words. Cham, Switzerland, Palgrave Macmillan, 2020, 250 pp., ISBN 978-3-030-35520-3
Authors: Mejías-Climent Laura
Published: May 2023

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SUSTAINABLE DEVELOPMENT GOALS, HERDING, AND RISK-AVERSE BEHAVIOUR IN MUSLIM COUNTRIES
Authors: Loang Ooi Kok
Published: May 2023

This study examines the impact of Sustainable Development Goals (SDGs) on behavioural biases, namely herding and risk-averse behaviours, in Sharia-compliant stocks. It also explores the mediating effect of investors' sentiments on the relationship between SDGs and behavioural biases. Adopting panel data and quantile regressions, we find that that SDGs 4, 8, 10, 11, and 13 significantly and positively correlate with stock returns in Indonesia, Kuwait, Oman, and Qatar. However, SDG 7 is the only SDG goal that is significant to Saudi and UAE stock returns. The results imply a complete mediation as the SDGs have caused changes in investors' sentiment and subsequently triggered the investors to herd and become risk-averse. The impact of SDGs is more pronounced in the upper and lower quantiles of Indonesia, Saudi, and UAE stock returns, as well as the median quantile of Bahrain, Kuwait, Oman, and Qatar stock returns. The results of this study can benefit policymakers, regulators, and practitioners in identifying the best SDG practices to assist Sharia-compliant stocks in Indonesia and Gulf Cooperation Council (GCC) countries to attain better stock returns and improve investors' sentiments and behaviours. The results can also assist governments in weighing the impact and benefits of adopting SDGs in different Muslim countries.
DETERMINANTS OF THE INTENTION TO PAY ZAKAT ONLINE: THE CASE OF INDONESIA
Authors: Kasri Rahmatina A. , Sosianti Meis Winih
Published: May 2023

In this paper, we extend the Unified Theory of Acceptance and Use of Technology (UTAUT) model to examine factors that shape the intention of Muslims in Indonesia to pay zakat online.  In the analysis, we include performance expectancy, effort expectancy, social influence, facilitating conditions, trust in zakat institutions, zakat literacy and Islamic religiosity as potential factors in the analysis.  The study employs primary data gathered from 734 respondents and uses the Structural Equation Modeling method for data analysis. The main result shows that facilitating conditions, performance expectancy, trust in zakat institutions, social influence, and zakat literacy influence the intention to pay zakat online. However, effort expectancy and Islamic religiosity turn out to be insignificant determinants of the intention to pay online zakat. The findings suggest that zakat stakeholders must enhance trust and intensify education about zakat. Zakat organizations must also improve the quality of the online zakat system, highlight the benefits of zakat online, and optimize the use of social media to increase zakat collection through digital channels.
Comparing patient-reported outcome measures for pain in women with pelvic floor disorders pre- and post-surgical management: A systematic review protocol
Authors: Hoque Sheymonti Shahreen , Ahern Susannah , O’Connell Helen E. , Romero Lorena , Ruseckaite Rasa
Published: May 2023

Background: Pelvic floor disorders including stress urinary incontinence and/or pelvic organ prolapse affect more than 50% of Australian women. Pelvic floor disorders cause a wide range of symptoms including painful urination, constipation and lower back pain. Previous surgical treatment may also affect the presence of pelvic symptoms, including pelvic pain, vaginal pain and dyspareunia which can lead to poor health-related quality of life. Patient-reported outcome measures are an important way of examining the health-related quality of life of women with pelvic floor disorders pre- and post-surgery, however, there are very few patient-reported outcome measures measuring this important domain of pelvic or vaginal pain. This paper aims to identify and compare patient-reported outcome measures for pain in women with a pelvic floor disorder in the existing literature, as well as to explore and highlight the gaps regarding the development and validation of a pain instrument. This review also aims to describe the modes and methods for administration of the instruments.
Methods: This review will be conducted based on the Preferred Reporting Items for Systematic review and Meta-Analysis Protocols guideline and checklist. Ovid MEDLINE, Ovid Embase, CINAHL Plus and Ovid PsychInfo databases as well as the grey literature will be searched for studies that use, develop or implement patient-reported outcome measures for pain as an HRQoL outcome in adult women with a pelvic floor disorder pre- and post-surgery. Studies reporting on the psychometric properties of patient-reported outcome measures will be included. An independent researcher will screen the title and abstracts of the studies. Two independent researchers will undertake full-text review and any disagreements will be resolved through discussion and consensus. The final selected studies will undergo data extraction, qualitative analysis and synthesis.
Discussion: The findings of this review will assist with the development and validation of new pain-specific patient-reported outcome measures for women with pelvic floor disorder in the registry or clinical practice.
Trial registration: CRD42022319663
Molecular surveillance leads to the first detection of Anopheles stephensi in Kenya.
Authors: Ochomo Eric O. , Milanoi Sylvia , Abong’o Bernard , Onyango Brenda , Muchoki Margaret , Omoke Diana , Olanga Evelyne , Njoroge Laban , Juma Elijah , Otieno James Dan , Matoke-Muhia Damaris , Kamau Luna , Rafferty Cristina , Gimnig John E. , Shieshia Mildred , Wacira Daniel , Mwangangi Joseph , Maia Marta , Chege Charles , Omar Ahmeddin , Rono Martin K , Abel Lucy , Obala Andrew , O’Meara Wendy Prudhomme , Mbogo Charles , Kariuki Lenson
Published: May 2023

Anopheles stephensi is an invasive malaria vector recently reported in Djibouti (2012), Ethiopia, Sudan (2019), Somalia (2019) and most recently Nigeria (2020). The World Health Organization (WHO) has called on all countries to scale up surveillance efforts to detect and report invasion by this vector and institute appropriate and effective control mechanisms. In Kenya, the Division for National Malaria Program (DNMP) conduct entomological surveillance in counties at risk of An. stephensi invasion. These efforts were supported by molecular surveillance of all sampled Anopheles mosquitoes from other studies conducted by the Kenya Medical Research Institute (KEMRI) to identify An. stephensi. In this article, we report the first detection of An. stephensi in Marsabit and Turkana Counties using PCR and confirmed by sequencing and morphological identification. This detection shows the urgent need for intensified surveillance to determine its occurrence and distribution and develop tailored approaches towards control to prevent further spread.
Impact of Body Mass Index on Pathological Response after Neoadjuvant Chemotherapy: Results from the I-SPY 2 trial
Authors: Wang Haiyun , Yee Douglas , Potter David , Jewett Patricia , Yau Christina , Beckwith Heather , Watson Allison , O'Grady Nicholas , Wilson Amy , Brain Susie , Pohlmann Paula , Blaes Anne
Published: May 2023

Purpose
Increased body mass index (BMI) has been associated with poor outcomes in women with breast cancer. We evaluated the association between BMI and pathological complete response (pCR) in the I-SPY 2 trial.
Methods
978 patientsenrolled in the I-SPY 2 trial 3/2010-11/2016 and had a recorded baseline BMI prior to treatment were included in the analysis. Tumor subtypes were defined by hormone receptor and HER2 status. Pretreatment BMI was categorized as obese (BMI≥30 kg/m2), overweight (25≤BMI < 30 kg/m2), and normal/underweight (< 25 kg/m2). pCR was defined as elimination of detectable invasive cancer in the breast and lymph nodes (ypT0/Tis and ypN0) at the time of surgery. Logistic regression analysis was used to determine associations between BMI and pCR. Event-free survival (EFS) and overall survival (OS) between different BMI categories were examined using Cox proportional hazards regression.
Results
The median age in the study population was 49 years. pCR rates were 32.8% in normal/underweight, 31.4% in overweight, and 32.5% in obese patients. In univariable analysis, there was no significant difference in pCR with BMI. In multivariable analysis adjusted for race/ethnicity, age, menopausal status, breast cancer subtype, and clinical stage, there was no significant difference in pCR after neoadjuvant chemotherapy for obese compared with normal/underweight patients (OR = 1.1, 95% CI: 0.68–1.63, p = 0.83), and for overweight compared with normal/underweight (OR = 1, 95% CI: 0.64–1.47, p = 0.88). We tested for potential interaction between BMI and breast cancer subtype; however, the interaction was not significant in the multivariable model (p = 0.09). Multivariate Cox regression showed there was no difference in EFS (p = 0.81) or OS (p = 0.52) between obese, overweight, and normal/underweight breast cancer patients with a median follow-up time of 3.8 years.
Conclusions
We found no difference in pCR rates by BMI with actual body weight based neoadjuvant chemotherapy in this biologically high-risk breast cancer population in the I-SPY2 trial.