bluuebunny/crossref_metadata_2025 huggingface dataset:
Variation in Linnaea borealis (Linnaeaceae) across North America and Greenland
Authors: Zika Peter F. , Tucker Gordon C.
Published: November 2021

Three subspecies of Linnaea borealis (Linnaeaceae) are reported from North America. We reviewed the literature and herbarium specimens, and were able to consistently recognize two taxa in the herbarium and in nature. Floral characters distinguish the two subspecies. Linnaea borealis subsp. borealis is widespread across Eurasia, and is common in the Aleutian Islands and mainland Alaska. Linnaea borealis subsp. longiflora is represented in eastern and southeastern Alaska, south to California, and east to the Atlantic and Greenland, and includes plants called subsp. americana. PCA and statistical analyses support the recognition of two infraspecific taxa. Lectotypes are designated for Linnaea borealis var. longiflora and Linnaea borealis var. longiflora forma orientalis. Also, a neotype is chosen for Linnaea americana.
[RETRACTED] Where to buy Cannaleafz CBD Gummies in Canada? [Does Cannaleafz CBD Gummies Canada Really Work or Scam?] v1
Authors: not provided jijubaba
Published: November 2021

[RETRACTED]

Health
[RETRACTED] Guardian Botanicals Blood Balance [AU] v1
Authors: S S
Published: November 2021

[RETRACTED]

Blood BalanceAustraliais primarily intended to control blood pressure and blood sugar levels, but it also benefits your cardiovascular system and overall health in a variety of ways. The following are some of the health advantages ofGuardian Botanicals:
Investigation of blaKPC and blaNDM genes in enterobacteriaceae received in a public health laboratory
Authors: Martins Laisla Zanetoni , Alves Elisabete Cardiga , Marques Denise Fusco , Lemos Ana Paula , Binhardi Fernanda Modesto Tolentino , Soares Marcia Maria Costa Nunes , De Santi Milena Polotto
Published: November 2021

Introduction: KPC and NDM carbapenemases production is an important enzymatic mechanism of resistance to carbapenens in bacteria belonging to the Enterobacteriaceae family. These enzymes degrade virtually all beta-lactam antibiotics and are encoded by the blaKPC and blaNDM genes, which can be in mobile genetic elements such as plasmids and transposons. Objectives: This study evaluated the positivity rate of the presence of blaKPC and blaNDM genes in carbapenem-resistant enterobacteria received at the Instituto Adolfo Lutz (IAL) of São José do Rio Preto, Brazil and determined the epidemiological data related to the patients whose isolates were recovered. Methods: From June 2015 to April 2019, bacterial isolates were obtained from different hospitals located in five municipalities in São José do Rio Preto region. In the bacteriology and molecular biology laboratory, DNA extraction and real-time PCR were performed to investigate the blaKPC and blaNDM genes. Afterwards, epidemiological data were surveyed such as the municipality of origin, age, and gender of the patients whose bacterial isolates were recovered. Results: A total of 934 enterobacteria isolates were recovered from the different hospitals. Of these; 93.4% were positive for blaKPC, with 96.3%, 1.85%, and 1.85% of the isolates belonged to the Klebsiella genus, Enterobacter genus, and Escherichia coli species, respectively. Also, 52.5% and 84.4% of the isolates were obtained from women and elderly patients, respectively. The blaNDM gene was detected only in three isolates, two of which originated from surveillance cultures. Conclusion: Therefore, KPC-producing enterobacteria are widespread in all health units of the five municipalities that were studied, suggesting that the blaKPC-carrying Klebsiella sp. isolates may be endemic in these institutions. Additionally, there is a significant role of surveillance cultures in preventing the spread of resistance genes, as observed for blaNDM in this study.
Rapid delivery with placenta previa
Authors: Kakushkin N.
Published: November 2021

Having listed the conditions under which bleeding usually occurs and is maintained during presentation of the child's place, the author examines various benefits, usually directed towards stopping bleeding.
Artificial mother's milk for feeding newborns
Authors: Kakushkin N.
Published: November 2021

We are talking about cow's milk, processed according to the Gaertner's method mechanically using a centrifugal machine. The composition of the milk obtained is close to the natural female.
A case of long-term retention of the fetus in the uterus
when breaking it
Authors: Abuladze D.
Published: November 2021

In today's meeting, I allow myself to occupy the attention of the Society with a detailed description of the case from our clinic, which is of interest, both in the sense of considerable pride, and in many other respects.
Hysteropexia abdominalis anterior or vaginofixatio uteri?
Authors: Shorr Ya. O.
Published: November 2021

The article was written about the fact that one of the doctors in Kherson had three hysteropexia, and one of the patients died.
A case of extrauterine pregnancy
Authors: Sobustianskiy E. M.
Published: November 2021

(Channel, behind. IMPERIAL Kazan Med. General 1898 January 16, No. 13, p. 385).Patient 25 years old, 7 years ago urgent delivery. 1 year ІО / g month ago she became pregnant in the second connector, at the end of the 5th month she felt fetal movement. Childbirth was 2 months late; this forced the patient to turn to the village midwives, who began to treat the patient with cow urine. After 2 months after that, pus appeared in the navel, and then the decaying limb of the fetus came out.
Intrauterine bleeding during pregnancy
Authors: Reimer G. N.
Published: November 2021

(Ezhenedlnik, 1898, No. 14, p. 263). A patient about 40 years old, multiparous, pregnant at the end of the 4th month. In the third month of pregnancy, she fell, after which she developed general weakness, anemia, pain in the abdomen and a gradually growing tumor in the abdomen, reaching up to the epigastric cavity (abdominal circumference 98 cm).
A case of a non-symmetrically constricted pelvis and a case of a flat pelvis as a result of a bone scar on the pubic junction in women in labor
Authors: Team Editorial
Published: November 2021

The case of a non-symmetrically constricted pelvis and the case of a flat pelvis due to the bone scar on the pubic junction in puerperas, No. 1, page 7. Finkelkraut (2) pointing out the works of Mikhnov, Schauta and War-tappA, goes on to describe the case of vaginal rupture during copulation, which was under observation in the abstraction. A patient of 40 years old, according to her words, last night she was raped by a healthy muschina for 26 years. Severe bleeding. The gap is located on the posterior wall of the vagina at the transition to the left and continues in depth to the posterior fornix, which is not torn.
Complete asymptomatic fundal rupture of the uterus in the first stage of labor
Authors: Mochalova Marina N. , Kuzmina Lyubov A. , Mironenko Anastasia Yu. , Likhanov Igor B. , Mudrov Viktor A.
Published: November 2021

A clinical case of a complete fundal rupture of the uterus at the first stage of labor of a woman with a uterine scar from a previous cesarean section in the lower uterine segment is addressed in this article. During clinical observation, the patient did not have hemorrhagic and pain syndromes. Operative delivery was performed due to primary uterine inertia. A newborn did not show any signs of asphyxia. During the operation, a rounded defect of 4 5 cm in size, penetrating the uterine cavity, was detected in the uterine fundus. It was sutured with a triple-row suture. The area of the lower segment was thinned to 2 mm, with deformation and defects not detected. In the postpartum period, subinvolution of the uterus was noted. The patient was discharged from hospital in satisfactory condition on the 10th day of the postpartum period.
Biochemical aspects of creation bacterial vaginosis
Authors: Karpishenko A. L. , Kira E. F. , Molchanov O. L.
Published: November 2021

In the review new data and the authors original opinion of the biochemical mechanisms in pathogenesis of bacterial vaginosis are represented.
Information about the Joint Plenum of the Interdepartmental Scientific Council for Obstetrics and Gynecology of the Russian Academy of Medical Sciences and the All-Russian Scientific-Practical Conference of the Association of Obstetricians and Gynecologists "Topical Questions of Infections in Obstetrics and Gynecology", Saint-Petersburg, May 26-28, 1998
Authors: Dolgov G. V.
Published: November 2021

On May 26-28, 1998, the Joint Plenum of the Interdepartmental Scientific Council for Obstetrics and Gynecology of the Russian Academy of Medical Sciences and the All-Russian Scientific Conference of the Association of Obstetricians and Gynecologists "Topical Questions of Infections in Obstetrics and Gynecology", dedicated to the 200th anniversary of the first Russian Chair in Obstetrics and Gynecology at the Military Medical Academy in Saint-Petersburg, were held.
Laparoscopy assisted minilaparotomy in the present uterine surgery
Authors: Savitskiy G. A. , Volkov N. N. , Ivanova R. D. , Gorbushin S. M.
Published: November 2021

It has been created the new technology of uterine surgery based on laparoscopy assisted suprapubical middle minilaparotomy. This operative method allows to minimize the surgical injure in the cases when laparoscopy itself may be difficult because of some reasons and typical laparotomy is undesirable. The first experience of these operations has shown that using of this technology does allow to decrease intraoperative blood loss considerably, reduce very much postoperative hospital stay of patients in comparison with laparotomy, minimize the necessity of analgetics, optimize the suture of the uterus in myomectomy and diminish the zone of coagulative necrosis of tissues.
Georgi Ermolaevitch Rein - academician, architect, Minister of Public Health Services
Authors: Tzvelev U. V. , Bezhenar V. F. , Ruhliada N. N.
Published: November 2021

Both the separate citizens, and all community and whole country require of the doctors, whose knowledge, results of their works were not left on the shelfs in libraries, but that they were done by real, common property of mankind, that they were spilled a wide wave along the country, bringing in everywhere a simplification of sufferings, reducing lethality and physical inability of the population, including mothers and born generation ...

G.E. Rein (1912).
Development dependence of human embryo from changes in cosmophysical situation within a year
Authors: Moiseeva N. I. , Evsukova L. I.
Published: November 2021

In the article the original sight of the authors on heliophysical aspects of embryogenesis is submitted. The new approaches in perinatal pathology reduction are revealed.
The diagnostics and treatment of dishormonal mammal hyperplasia in uterine myoma patients
Authors: Tzvelev Ju. V. , Ilyin A. B.
Published: November 2021

In gynecologic patients with internal genitalia diseases (endometriosis, uterine myoma) the frequency of mammal hyperplasia makes up to 60- 95%. The research aim was to study the effectiveness of conservative therapy with gestagens (norcolut, orgametril) application in benign hyperplastic mammal processes management in patients with uterine myomas. The effectiveness of gestagens application in patients with uterine myomas with coexisting dyshormonal mammal hyperplasia is proved.
Organ-saving operations in gynecological practice
Authors: Shamarin D. L. , Kira E. F.
Published: November 2021

In the article the basic statistical data about the myoma myometrium morbidity are set up. The consequences after radical operations concerning benign lesions of a uterus and adnex are described. The expediency of more broad organ-saving operations application is justified. The new tactics of myoma management is shown. The basic criteria are considered by selection of a method of treatment and definition of a operation volume, which are closely connected to the appeared modern methods of diagnostics. Here are described the most used in daily practice organ-saving methods of surgical treatment.
Peculiarities of the course of the menopausal period in women with endocrine system diseases
Authors: Melnichenko G. A. , Kathuria Yu. V. , Chazova T. E. , Berketova T. Yu. , Fadeev V. V. , Pivovarova S. V.
Published: November 2021

In recent decades, there has been a clear trend towards an increase in the life expectancy of the population. In the 1990s it reached 78.9 years for women. The global population of postmenopausal women today is 10%. According to WHO projections 46% of women are expected to be over 45 years old by 2015. The age of menopause remains fairly stable and in different regions of Russia is 49-50 years. Consequently, a woman spends more than a third of her life in a state of deficiency of female sex hormones.
Morphological and microbiological endometrium researches in examination of the patients with tubal-peritoneal infertility at a stage of preparation to IVF
Authors: Corsac V. S. , Bodul A. S. , Isakova E. V. , Savitcheva A. M. , Tchemodanova E. B.
Published: November 2021

At 102 patients with tubal-peritoneal infertility at examination after unsuccessful attempt of IVF in 1 phase (8-10 days) of menstrual cycle was made a biopsy of endometrium with subsequent histologic and microbiological research of the material. The pathology of endometrium was revealed in 67,7 % patients. As a result of microbiological pathogenic and is conditional - pathogenic microorganisms are allocated in 29 (28,4 % ) women (streptococci of group В - at 16 ( 15,7 %) patients, chlamydia - at 11 (10,7 %), mycoplasma - at 2 (1,9 %). And the morphological endometrium pathology was found at 18, in others 11 cases the persistence of these microorganisms in endometrium was not accompanied with any histologic manifestation of inflammatory process. All patients with verified diagnosis of chronic endometritis have passed a rate complex thiopathognie therapy. In the result of treatment after attempt for IVF the pregnancy has come in 58,8 % of cases. The morphological and microbiological researches of endometrium should be included in examination of patients with tubal- peritoneal infertility at a stage of preparation to IVF in connection with high frequency of infectional pathology of endometrium to this group of the patients.
Quality-of-life of the women after surgical treatment of ectopic pregnancy
Authors: Kira E. F. , Bezhenar V. F. , Ruhliada N. N.
Published: November 2021

Estimation of quality-of-life (QOL) - modern method of researches allowing to reveal even insignificant change in any spheres of ones life with the purpose of all-round definition of efficiency of treatment. The questionnaire, developed by the authors, for an QOL estimation f the patients after operations concerning ectopic pregnancy has high sensitivity, and allows to reveal statistically significant authentic distinctions since 14 day postoperation. The conducting factor determining QOL of patients after all kinds of surgical ectopic pregnancy treatment is the infertility. The increase of a share carried out organ-saving operations considerably improves reproductive health of the population in comparison with results of radical surgeries with removal of uterine tube, that is reflected in fastest positive dynamics in QOL in various terms after operation.
Role of total antioxidant capacity and oxidative stress in fertilization and embryo selection in the IVF cycle
Authors: SEYFETTİNOĞLU Sevtap , ŞAHİN Gülnaz , AKDOĞAN Ayşin , TAVMERGEN GÖKER Ege Nazan , AKÇAY Yasemin , Y. SÖZMEN Eser , TAVMERGEN Erol
Published: November 2021

Purpose: This study aims to evaluate the oxidant and antioxidant parameters in follicular fluid and embryo culture medium in IVF cycles and investigate their effects on embryo quality, fertilization success, and pregnancy.

Materials and Methods: Fifty-one patients who underwent IVF/ICSI were included in this prospective study. Two hundred sixty of a total of 454 follicular fluids and the cell culture media of transferred fifty-one embryos (one from each patient) were examined. Antioxidant activity (AOA), Trolox equivalent antioxidant capacity (TEAC), thiobarbiturate reactive substances (TBARS), ferric antioxidant power (FRAP), paraoxonase, nitrotyrosine were analyzed.

Results: TBARS were significantly lower in the follicular fluid of fertilized oocytes than in non-fertilized oocytes (21 vs. 29.75 nmol/ml). There was no difference in terms of other parameters. TEAC levels were higher in oocytes in the agonist protocol group than in the antagonist protocol group. In terms of embryo quality, there were no differences between the groups in any analysis. TEAC levels were higher in the embryo cell culture medium in the group that became pregnant after embryo transfer on the second day.

Conclusion: When oxidative stress and antioxidant parameters were evaluated in both follicle fluid and embryo cell culture medium, it was determined that lipid peroxidation negatively affected fertilization. However, there is no significant difference in terms of embryo quality and pregnancy rates.
Seismic Response of 2D Topographic Profiles for Incident SH Waves: Iterative Solution and Comparison of Direct and Indirect BEM
Authors: Mejía-López Jimena , López-Sugahara Oscar I. , Piña-Flores José , Sánchez-Sesma Francisco J. , Ge Zengxi , Wei Jia , Rong Mianshui , Ba Zhenning
Published: November 2021

The scattering and diffraction of waves by irregular surface profiles is of interest in seismology and in many other areas. Diverse techniques have been proposed to quantitatively study the problem. Among them, domain approaches such as finite differences, spectral elements and finite elements have been used. Because the reduction of dimensionality boundary formulations is widely used. Recently, the direct boundary-element method has been applied using some series approximations for surface scattering, including the preconditioned splitting series, for the numerical description of rough surface scattering. Extending further and simplifying this approach, we use the indirect boundary-element method. The ensuing Fredholm integral equation of the second kind that arises in IBEM leads to a very efficient iterative scheme based on the classical Jacobi method. A discussion of direct and indirect approaches is presented. Assuming incident SH waves, results are obtained with the various approaches and compared among them for both a canyon and a hill, both of semicircular shape. Besides, an example is presented of a surface profile that produces strong scattering. This was inspired by the diverse problems that arise in the emerging field of metamaterials.
Regiones inteligentes: la tecnología, la innovación y la efectividad operativa
Authors:   Universidad Icesi, Santa Ricardo , Morante Diego ,   Escuela Militar de Aviación “Marco Fidel Suárez” (EMAVI), Tegethoff Thomas ,   Universidad Icesi
Published: November 2021

El libro Regiones inteligentes: la tecnología, la innovación y la efectividad operativa tiene como objetivo evaluar las capacidades de diferentes organizaciones colombianas para enfrentar el reto de transformación hacia la Industria 4.0, enfocado desde la tecnología e innovación para generar un desempeño óptimo o, en los términos del libro, alcanzar una efectividad que induzca a la competitividad de las organizaciones [Ricardo Santa, Diego Morante y Thomas Tegethoff].
Efectos de la COVID-19 en el ritmo empresarial colombiano
Authors:   Universidad Icesi, Varela Villegas Rodrigo , Arango Carlos ,   Universidad Icesi, Soler Librero Juan David ,   Universidad Icesi
Published: November 2021

El alcance previsto en este libro es múltiple: mostrar, a partir del sentir de los colombianos en general y de los empresarios en particular, la situación empresarial colombiana seis (6) meses después de reconocida la COVID-19 como pandemia; evaluar el uso que los empresarios colombianos le han dado a los programas que el gobierno nacional ha ofrecido; proponer algunas acciones de política pública que se puedan implementar y que ayuden a la recuperación del tejido empresarial; continuar apoyando las investigaciones sobre el proceso empresarial colombiano; demostrar como un esfuerzo Universidad-Gobierno-Empresarios para hacer investigación produce resultados útiles; invitar a otras organizaciones a apoyar este esfuerzo investigativo. Pero esta investigación tiene un componente muy especial y es el hecho de haberse diseñado y ejecutado con el propósito de medir los efectos, en la actividad empresarial colombiana, de la pandemia COVID-19, en adición de medir todas las variables propias al estudio Global Entrepreneurship Monitor (GEM).
Mixed Flow Assembly Line Balancing Problem Considering Material Supply Strategy
Authors:   Institute of Logistics Science and Engineering, Shanghai Maritime University, China, Yujia Zhou , Jin Shen , Wu Bin , Daofang Chang
Published: November 2021

With the capacity limitation of the assembly line buffer area, a method for solving the mixed flow assembly line balancing problem considering material supply strategy is proposed. This paper analyzes the changes in material transportation time and assembly time due to different supply strategies, and proposes a method for jointly modeling the assembly line balancing and material supply problem. In the case of meeting the production cycle, with the buffer area capacity as the limit and the shortest production operation time as the goal, a joint optimization model including material handling time, material transportation time and assembly line working time is established, and the model is designed for the established model Genetic algorithm with piecewise coding. Finally, the proposed algorithm was evaluated using a workshop raw date， the simulation results show that although the indirect supply cost is relatively more than the direct supply, it can effectively alleviate the problem of the capacity limitation of the buffer area.
Depression and coping strategies used among adolescents with cystic fibrosis
Authors: Tiwari Surya Kant , Sharma Rimple , Joshi Poonam , Kabra Sushil Kumar
Published: November 2021

Background: Cystic fibrosis (CF), an autosomal recessive monogenic chronic disorder affects the lungs, pancreas, and other exocrine glands, and manifests as recurrent respiratory infections, malabsorption, and a myriad of complications pertaining to other systems like hepatobiliary, endocrine and reproductive systems.  Objectives were to assess the level of depression among adolescents with CF, to assess the coping strategies used by adolescents with CF and to find an association between selected sociodemographic and clinical variables with depression.Methods: In a cross-sectional survey, 30 adolescents with CF in the age group of 12-18 years, attending the specialty clinic of a selected tertiary care facility were enrolled using a purposive sampling technique. Tools consisting of sociodemographic and clinical profile, patient health questionnaire (PHQ)-9, and ways of coping with CF were used for data collection.Results: Most of the adolescents with CF (66.7%) had depression of varying severity with 36.7% having moderate-severe to severe depression. The frequently used coping strategies by the adolescents with CF were hopefulness (76.66±11.29), followed by optimistic acceptance (70.23±13.04).  The individual coping strategy with the highest mean score was “having confidence on doctor and treatment” (3.83±0.37), while ‘I cry, eat, drink or take drugs’ had the lowest score (1.6±1.00).Conclusion: Depression is a common problem among adolescents with CF requiring regular screening and referral to experts for enhancing their coping strategy of optimistic acceptance.
Impact of postnatal counseling on care of newborn
Authors: Vijayalakshmi Vantaku Venkata , Padma K. Jhansi , Mohan M. Madan , Manikyamba D. , Prasad A. Krishna
Published: November 2021

Background: Newborn care is an integral aspect of child health care practices. Globally 2.4 million children died in the neonatal period in 2019. Currently in India around 7.47 lakh neonates die annually. Advocating and adopting proper postnatal care of newborn in aspects of breastfeeding, immunization, warmth care, cord care, eye care etc will help in reducing neonatal morbidity and mortality.Methods: This was an hospital based cross sectional study of 100 postnatal mothers of babies admitted in NICU, in a tertiary care hospital. The knowledge of the mothers on various aspects of postnatal care was assessed by a pretest, followed by counseling and reassessment with a post test.Results: The study found that postnatal mothers had better awareness regarding breastfeeding, warmth care, cord care and oil massage. Poor knowledge was seen regarding eye care, immunization, recognition of danger signs and maternal nutrition and supplementation. Health care workers focused more on breastfeeding and warmth care practices than other aspects of postnatal care during antenatal counseling which could be a reason for this. A wide gap exists between contact with health workers and antenatal counseling. Knowledge gaps of the mothers improved significantly after counseling irrespective of their parity, education and location as seen by the increase in mean scores.Conclusions: Neonatal morbidity and mortality due to avoidable causes like hypoglycemia, hypothermia, sepsis can be achieved by practicing appropriate post-natal care practices. WHO recommendations on these practices should be widely propagated through frequent antenatal and post-natal counseling by health care workers.
Neonatal hepatitis in a term newborn: sequelae to in utero COVID-19 infection
Authors: Kaur Pushwinder
Published: November 2021

Neonatal hepatitis is a common disease entity seen among newborns. It is known as inflammation of liver parenchyma in newborns, specifically in first month of life. Most common cause of neonatal hepatitis is viral infection which infects liver in utero or in postnatal period. Newborns carrying neonatal hepatitis mostly present with jaundice, failure to gain weight and hepatosplenomegaly. Neonatal hepatitis due to in utero COVID infection is diagnosed by conjugated hyperbilirubinemia, raised SGOT and SGPT levels and raised COVID antibody levels.  Treatment includes addition of fat-soluble vitamins, phenobarbitone and supportive care. Here author is reporting a rare case of 11 days old newborn with neonatal hepatitis, who presented with severe jaundice (TSB/DB- 44/22) hepatosplenomegaly and hypoxemia with mild respiratory distress. Maternal history revealed high grade fever with low cell count during 5th month of gestation, though COVID RAT was negative and RT-PCR was not done. Baby was managed in NICU with IV antibiotics, IV fluids, oxygen by prongs, oral fat-soluble vitamin supplementation, adequate calorie intake and phenobarbitone. Baby responded very well to the treatment and discharged in healthy condition after 7 days. Paucity of data documenting in utero COVID-19 infection as cause of neonatal hepatitis led us to report this rare case.
Non-suicidal intentional ingestion of iron tablets and severe intoxication: the result of adolescent boy’s impulsive risky behaviour in the school
Authors: Tandon Krutika Rahul , Tandon Rahul , Khandwala Amola , Mehta Tanvi
Published: November 2021

Acute iron poisoning is a potentially fatal intoxication in children. As the Iron preparations are commonly administered to pregnant women, lactating mothers, toddlers, it is easily available at home. So younger children are prone to consume it accidently. Although iron is a therapeutic drug in recommended dosages, excessive iron in the free state can produce toxicity by affecting multiple cellular processes by catalysing redox reactions with lipid peroxidation and free radical formation. The severity of intoxication depends on the amount of elemental iron ingested. Serious toxicity is usually associated with a dose of >40 mg/kg of elemental iron. Levels more than 100 mg/kg are almost always fatal. We report a case where a 12-year male child intentionally taken 60 tablets of iron (ferrous fumarate) at his school as a part of competition or bet to other schoolmate and presented with acute iron poisoning with hepatic encephalopathy to us. Important initial laboratory parameters were AST-4,879 U/L, Prothrombin time-60 sec and Iron level-213 microgram/dl. With timely specific management i.e., deferoxamine infusion along with all required intensive care supportive management in PICU the patient was discharged successfully. We chose to report this case to highlight the risky behaviour of adolescence who usually grows physically and emotionally earlier but their prefrontal lobes are yet immature to take proper and correct decision. Thus, impulse activity may prove fatal for them.
Aerosolized type II transmembrane serine protease 2 inhibitor to combat COVID-19: a proposal
Authors: Raybarman Chandan , Bhattacharjee Surajit
Published: November 2021

Type II transmembrane serine protease (TMPRSS2) is expressed at the cell surface with COVID-19 infection. And COVID-19 infection misuse TMPRSS2 to advance their spread, making this protease potential focuses for intervention in COVID-19 infection. TMPRSS2 blocker may be the appropriate option to arrest cellular entry of COVID-19 by deregulating spike priming. Therefore a trial may be intended to watch the adequacy of aerosolized spraying of TMPRSS2 inhibitors to break the viral entry to the objective cells that empower to break the COVID-19 transmission. Targeting TMPRSS2 through aerosolized TMPRSS2 inhibitor is important to examine a possibly viable remedial technique in the treatment of COVID-19.
Atypical hand foot mouth disease presenting as vesiculobullous lesion
Authors: Lohidakshan Nihil E. , Srinivas Chakravarthi R. , Alanghat Sruthi
Published: November 2021

Hand, food, and mouth disease (HFMD) is a highly contagious disease caused by enteroviruses affecting young children under 5 years. Among enteroviruses (EVs), the main pathogens of HFMD are coxsackievirus A16 (CV-A16) and EV-A71 (EV-71).1 The clinical features include a prodromal phase which has low-grade fever, malaise and sore throat. This initial phase is usually followed by enanthem and erythematous papular skin lesions, predominantly affecting palms and soles. The dorsal surface of hands, feet, and perioral skin are rarely affected. Atypical HFMD presents as a widely distributed rash with varying morphology that makes clinical diagnosis and treatment challenging.2 Our objective is to present atypical cutaneous manifestations of HFMD caused by CA6.
Liquid based cytology and immunohistochemistry on cytosmears based diagnosis of letterer-siwe disease in a 40 year male
Authors: Agarwal Preeti , Khan Fatima , Gupta Vaibhav , Dubey Devanshi
Published: November 2021

: Histiocytes with coffee bean like nucleus are the diagnostic hallmark of Langerhans cell histiocytosis (LCH) supported with immunohistochemical (IHC) demonstration of fascin, CD1a and S-100. We report a case of Letterer-Siwe disease in a 40year male diagnosed on cytology and IHC on cytosmears along with cytomorphology in Liquid based cytology (LBC) smears.

Forty year male presented with complains of low grade fever and reduced appetite from two years with a cervical swelling and discomfort from five months.

Fine needle aspiration(FNA) from cervical lymph node showed sheets of histiocytes in background of mixed inflammatory cells. LBC smears highlighted fine chromatin, delicate nuclear outline with coffee bean like morphology. On IHC tumor cells were positive for S-100 and CD1a. CT thorax revealed consolidation in left lower lung, bone lesions were found on skeletal survey.

Hence diagnosis of Letterer-Siwe disease was given. Patient responded well to systemic chemotherapy.
Estudios electrónicos y electroquímicos del 2,2-bis[5´- (2´-carbonilfuranil)]propano
Authors: Galarza Esperanza
Published: November 2021

En este estudio se reporta la síntesis y caracterización del compuesto 2,2-bis[5´-(2´-carbonilfuranil)] propano (BCFP), el cual es un prototipo de bloque de construcción para la preparación de macrociclos, polímeros e, incluso, estructuras supramoleculares con diferentes aplicaciones. La síntesis del BCFP se llevó a cabo a través de la reacción de Vilsmeier-Haack del 2,2-bis(2´-furanil) propano usando N,N-dimetilformamida (DMF) y cloruro de fosforilo (POCl3), con un 55 % de rendimiento. El compuesto exhibió una transición nπ* característica de compuestos con átomos sp2 que contienen pares libres no enlazantes. Mediante voltamperometría cíclica se evidenciaron dos procesos redox (reducción y oxidación) de naturaleza electroquímica y química irreversible. Los cálculos teóricos basados en la teoría del funcional de la densidad (density functional theory, DFT) corroboraron las transiciones electrónicas y los procesos redox. Los orbitales moleculares de frontera (HOMO y LUMO) fueron dominados por los grupos aldehído y los anillos de furano.
Editorial
Authors: López Zaldívar Halley
Published: November 2021

El actual contexto, provocado por la pandemia de la COVID-19, ha generado cambios profundos en el sistema educativo y, en alguna medida, en el sistema de investigación en toda latitud. No obstante ello, así como los educadores y educandos, los investigadores han logrado adaptarse a estas nuevas circunstancias, lo que incluso ha llevado a identificar nuevos espacios para la aplicación de las categorías jurídicas, tal es así que se ha llamado la atención hacia nuevas áreas relacionadas con la sanidad, los derechos colectivos, además del análisis crítico de las herramientas actuales y su capacidad para atender los efectos generados por la pandemia.
El conocimiento del profesional del derecho sobre los aspectos jurídicos del expediente clínico en México
Authors: Bravo Acevedo Omar , González Contreras Fernando , Santana Campas Marco
Published: November 2021

A medida que avanzan los años, las ciencias jurídicas van evolucionando y adaptándose a nuevas realidades y contextos sociales, y estas pretenden que las personas interactúen y vivan en armonía con sus semejantes, por lo que es indispensable regular la conducta y actividad humana en cada área del Derecho. En este artículo se estudió una figura jurídica del área de la medicina, específicamente el expediente clínico, el cual se origina a partir del servicio de atención médica entre el profesional de la salud y el paciente, por lo que el objetivo principal de esta investigación fue establecer los aspectos jurídicos básicos del expediente clínico que debe conocer el profesional del Derecho para que pueda proceder legalmente en representación de los usuarios de la salud, ante la autoridad competente. A efecto de cumplir con el objetivo de esta investigación, se usó la metodología cualitativa documental, a través de la revisión sistemática de la literatura, donde se identificó los aspectos jurídicos básicos que son del interés del abogado y que este debe conocer, así como las sanciones que contempla la legislación mexicana en contra de los médicos por el mal manejo del expediente clínico.
Kindfull-Digital Character Book Effectiveness: A User Satisfaction Approach
Authors: Fitriati Azmi , Anggoro Subuh , Harmianto Sri , Tubastuvi Naelati
Published: November 2021

This study aims to examine the effect of user competence on system quality and user satisfaction with the use of the kindfull-digital character book apps. The quality of the system is measured by indicators of flexibility and accessibility. Then, user satisfaction affected the acceptance of a system. Survey method with quantitative measurements were used. Respondents where users of the application include teachers’ and parents. Data were collected using a questionnaire. The analysis technique used is Structural Equation Modeling - Partial Least Square. The results showed that user competence had an effect on system quality. Then, competent users improve system quality. Furthermore, the quality of the system can increase user satisfaction. Satisfied users will always use IS. Thus, resulted monitoring will also be more accurate, complete and timely. Based on these results, were suggested to increase the user's knowledge and skills. So, the quality of the system will improve. The perceived satisfaction will increase their use. Then, application usage training is needed to improve their competence. Thus, the quality of the system can be improved through flexibility and accessibility. The app interface design should be made more user-friendly by providing simple features, compliant content accompanied by interested display.
The Degradation of the Territories of Snow Polygons
Authors: Pasko O.A. , Zakharchenko A.V.
Published: November 2021

The assessment of the degree of degradation of the soil and vegetation cover in the territory of storage of snow masses was carried out. It is established that in the soils of the polygons there is a decrease in the reserves of organic carbon, an increase in the power of the abiotic alluvial layer, a reduction in the power of the upper part of the soil profile, washouts and algae are formed. It is determined that the soil filtration coefficients are low. Stagnation of water near the surface and prolonged waterlogging against the background of low temperatures during the entire period of snowmelt were revealed. The soils of all snow polygons are characterized as highly degraded. They have lost their valuable functions for humans and need to be reclaimed.
Ecological Safe Concentrations of Oil in the Soils of the Black Sea Coast of the Caucasus
Authors: Kuzina A.A. , Kolesnikov S.I. , Minnikova T.V. , Gaivoronsky V.G. , Nevedomaya E.N. , Ter-Misakyants T.A. , Kazeev K.Sh.
Published: November 2021

Environmentally safe concentrations of oil in the soils of wet and dry subtropics of the Black Sea coast of the Caucasus (Black Sea Coast) have been established according to the degree of violation of their ecological functions. The indicators of the number of bacteria, the activity of soil enzymes, plant growth and development were determined. Based on the analysis of the degree of disruption of the ecological functions of soils, regional values of the maximum permissible concentrations of oil in the soils of the Black Sea Coast have been established.
ANTAGONISTIC ACTIVITY OF ACTINOMYCETES ISOLATED FROM SALINE SOILS NEAR WITH KUMISI LAKE (GEORGIA)
Authors: Tsulukidze M. D. , Lomtatidze Z. Sh. , Mamulashvili Q. H.
Published: November 2021

Aim. To study the antagonistic activity of actinomycetes isolated from soils adjacent to Kumisi Lake (Georgia). Methods. It was used 12 samples of actinomycetes isolated from the soils adjacent to Kumisi Lake. The antibiotic activity of actinomycetes was determined using test strains: Escherichia coli К-12 (B-3254), Bacillus subtilis 26 D, Xanthomonas campestris В-1459, Rhizobium radiobacter C58, Pectobacterium carotovorum EC1by the method of agar blocks. Results. It was revealed that actinomycete samples isolated from soils adjacent to Lake Kumisi shown the most significant inhibitory effect on test strains: Escherichia coli B-3254, Rhizobium radiobacter C58 and Xanthomonas campestris В-1459. The most resistant test-strains, to the studied actinomycetes, were Bacillus subtilis 26 D and Pectobacterium carotovorum EC1. Conclusion. Isolated strain 301 of actinomycetes shown a significant antagonistic effect on all test strains and could be potential for further studies spectrum and properties of antibiotic compounds.
ACCUMULATION OF α-TOCOPHEROL IN MICROALGAE CELLS
Authors: Mokrosnop V. M. , Zolotareva E. K.
Published: November 2021

To date, the main natural source of vitamin E is vegetable oils. Among the compounds of the vitamin E group, α-tocopherol has the higher biological activity, the relative content of which in vegetable oils is comparatively small. Significantly higher concentrations of α-tocopherol (up to 4-6 mg / g dry weight) accumulate some microalgae, such as Euglena gracilis, Dunaliella tertiolecta, Nannochloropsis oculata, Tetraselmis suecica and others. Due to this, there has been a growing interest in biotechnology of microalgae as a raw material for the production of vitamins. The largest amount of tocopherols is synthesized in Euglena gracilis cells by myxorotrophic cultivation.Lipid-soluble α-tocopherol is a component of the non-enzymatic antioxidant system and performs the function of protecting cell membranes from reactive oxygen species and free radicals. As a result of many studies, the dependence of the level of α-tocopherol accumulation on the conditions of cultivation of microalgae, including light intensity, photoperiod, nitrogen level, temperature, type of carbon nutrition, etc. At the same time, stressful conditions stimulate the accumulation of antioxidants in photosynthetic organisms, but limit the normal rate of their growth. The problem of increasing the yield of tocopherols is solved in systems of two-stage cultivation through the separation in time of the stage of biomass accumulation and the stage of stimulation of α-tocopherol biosynthesis. The increase in tocopherol content is achieved due to the introduction of exogenous carbon sources at the stage of biomass accumulation and limiting the nutrient medium for some nutrients at the stage of stimulating the synthesis of antioxidants. The review presents data on the effects of the composition of the nutrient medium, type of nutrition, temperature, light intensity, cultivation technique on the accumulation of vitamin E by microalgae cells.
Processing pineapple pulp into dietary fibre supplement
Authors:   University of Ghana, Ackom NB , Tano-Debrah K
Published: November 2021

Several tonnes of conventionally consumed dietary fibre-containing fruit components are discarded as wastes in the processing of fruits into fruit juices, resulting in the loss of food nutrients and the increased production of organic waste. A study was done to investigate the processing of pineapple pulp waste from a processing plant, into a powdered product to be used as a dietary fibre supplement. The proximate composition and the functional properties of the raw material and final product were determined. The pasting characteristics or properties of wheat flour fortified with the product up to 20 % were also determined using a viscoamylograph. The wheat flour fortified at 10 % level was used to prepare cookies and muffins after which it was subject to a performance test. Proximate analysis of the product showed crude fibre content of about 30 %; crude protein: 8.5 %; crude fat: 1.5 %; total ash: 5.2 %, and ascorbic acid: 20 mg/100 g. The fat and water absorption capacities were 2.5 g/g and 2.0 g/g of product respectively. The foaming and gelation capacities of the product were found to be 2.8 % and 12 %, respectively. Changes in the pasting characteristics of the whole-wheat flour with the 10% level of fortification were not statistically significant. Acceptance levels of the cookies and muffins made from the composite flour were high and much preference was shown for samples from the fortified flour compared to samples from whole-wheat flour without fortification. This study demonstrated a potential way of harnessing pineapple pulp, a dietary fibre source, which is lost in fruit processing. This will improve the economic value to pineapple, which is widely cultivated in Ghana. It also demonstrated a way of increasing the dietary fibre content of some popular foods to help increase the fibre intake and health of the general population.
Dietary therapy of obesity: Effect on some hormonal and biochemical blood indices
Authors:   National Research center, Cairo, Egypt, Salwa ME , Maha IAM , Hamed IM , Salwa TT , Laila MH , Lobna AG
Published: November 2021

It is now clear that the presence of obesity substantially increases the risk of related co-morbidities such as insulin resistance, diabetes, dyslipidemia, hypertension and others. The objective of this study was to measure adiponectin, insulin hormones, and homocysteine concentrations in obese Egyptian women before and after diet therapy that consisted of a hypo -caloric regimen supplemented with a formula rich in dietary fiber, folate and betaine. This study investigated serum adiponectin, insulin, homocysteine, lipid profiles, haemoglobin and homeostatic model assessment (HOMA) value in twenty eight volunteer obese women, whose mean age was 47.86±2.18 years and body mass index (BMI) was 34.10± 0.95 kg/m 2 . The studied period was 8 weeks divided into two phases, 1 and 2 of 4 weeks each. In the first phase, the women consumed a hypo- caloric diet (900 -1000 Kcal/day) plus the supplement made from highly extracted wheat (82%) comp osited with ground peanuts at a 50:50 ratio, prepared as cookies of; 20 g each. Two cookies were consumed at breakfast and one at dinner, to replace the bread carbohydrate content. In the second phase , the same subjects consumed only the hypo- caloric diet. Results showed that fasting serum glucose, insulin, homocysteine concentrations and HOMA values were reduced significantly (P<0.01) at the end of the 1 st phase, while adiponectin hormone was slightly decreased (1.3%). Homocysteine concentration increased significantly (P<0.05) at the end of the 2 nd phase, while the other parameters showed only numerical increase. Adiponectin was positively correlated with high density lipoprotein cholesterol (HDL -C) at P<0.01 at all phases of the study, while insulin and HOMA were negatively associated at the start of the study. Homocysteine was positively correlated (P<0.05 and P<0.01) with cholesterol, low density lipoprotein cholesterol (LDL -C) and glucose at the basal test, than with systolic blood pressure (SBP), diastolic blood pressure (DBP), and HOMA (P<0.01) at the end of the 1st phase. In conclusion, the weight reducing diet supplemented with the dietary fiber rich formula in the short -term might have a beneficial effect on body weight, insulin and homocysteine. A diponectin showed minor changes, but its role against dyslipidemia could be suggested.
A comparison of the kinetics of mango drying in open-air, solar, and forced-air dryers
Authors:   University of Guelph, Canada, Mercer DG
Published: November 2021

Mangoes are under-utilized fruits that grow naturally in many sub-Saharan African countries. At the present time most mangoes are sold fresh in local markets. There is little done to preserve them for use during the off-season. Drying is one way in which the economic potential of mangoes could be exploited. This study was undertaken to investigate and compare the kinetics of mango drying using three basic drying methods: open-air drying on wire mesh racks; solar drying in a prototype dryer equipped with solar-powered exhaust fans; and forced-air drying in an Armfield Model UOP8 laboratory-scale tray dryer. Results could then be used to determine appropriate drying techniques for mango processing in sub-Saharan Africa on both local and commercial scales. Of these methods, forced air drying was found to provide the best overall results, based on water removal rates and general control over the drying process. Solar drying, while viewed as a promising technology for application in developing countries, was considerably slower than forced- air drying and is severely restricted by climatic conditions. A similar situation was observed for open-air drying, which was the slowest drying method of the three. Based upon mathematical models developed for each drying method, 11.6 hours was predicted as being required for mangoes in the forced-air dryer to a final moisture content of 10% (wet basis). Sixteen (16) hours and 24 hours of exposure to appropriate drying conditions were predicted as being required for solar drying and open-air drying, respectively. This could take three or four days to achieve under actual operating conditions. These times were supported by experimentally determined values. The impact of air temperature and linear air velocity on the drying kinetics of sliced mangoes were also investigated using the forced-air dryer. A linear velocity of 0.5 m/s was found to be sufficient for satisfactory drying of the mango slices when combined with an air temperature in the range of 50ΕC to 60ΕC. It is recommended that forced-air drying be utilized whenever possible for the drying of mango slices for both food safety and food quality reasons.