bluuebunny/crossref_metadata_2025 huggingface dataset:
Localized Litmus Paper and Computer Interactive Simulator in Teaching Acids and Bases
Authors: Benong Christopher Bernard , Piñero Brando , Futalan Maria Chona , Benong Shery-Ann
Published: June 2024

This study aimed to determine the effectiveness of using localized litmus paper and computer interactive simulation in teaching the concepts of acids and bases. The respondents of the study are the grade seven students of a private school in Dumaguete City, during the academic year 2023-2024. The researcher utilized the descriptive, correlational, comparative, and Cluster-Randomized Controlled Trial (CRT) methods of research. This study also made use of researcher-made questionnaires that measured the performance of the students in using the two methods of instruction, respectively. The statistical tools used in this study include standard deviation, mean, t-tests for dependent and independent data, and Spearman’s rho. The findings revealed that there is a significant improvement in the student’s performance after using localized litmus paper (p=0.001 < α=0.05) and computer interactive simulator (p=0.000 < α=0.05). Overall, both methods of instruction proved to be vital and effective (p= 0.597 > 0.05) in the student’s learning of the concepts of acids and bases. The results suggest that both approaches can be valuable tools for educators, enabling them to effectively cater to students’ different learning styles or maximize teaching effectiveness through varied instructional strategies. While using both methods of instruction resulted in comparable posttest success, the usage must be coupled with classroom dynamics, a helpful learning environment, improved study habits of students, and teachers’ positive behavior to achieve higher student performance. Additionally, the findings indicate that both methods are useful teaching tools that the Department of Education and various private basic education institutions can use in teaching acid-base lessons.
Persuasion in the Business Speeches of Chief Executive Officers of Selected International Companies
Authors: Yingying Su , Munal Leonardo
Published: June 2024

This study investigated the persuasive strategies employed in the business speeches of Chief Executive Officers (CEOs) of selected international companies. Anchored in Speech Act Theory within the broader aspect of pragmatics, it analyzed 12 speeches, totalling 14,938 words, from a diverse range of international CEOs. These speeches, intended for both employees and shareholders, provided a rich corpus for examining the nuances of persuasion in a business context. The analysis focused on identifying various categories of persuasion, particularly distinguishing between direct and indirect speech acts. Utilizing a qualitative approach, 1,172 clauses were coded to elucidate the persuasive mechanisms at play. Findings revealed a predominant use of indirect persuasion by CEOs. Despite their intention to persuade, these business leaders predominantly opted for subtle, indirect speech acts, making their persuasive intent both non-obvious and inherent. Contrary to expectations, the study found a marked absence of direct rhetorical devices such as rhetorical questions, suppositions, and wonderings. This aligned with the pragmatic realities of business communication, which often eschews overtly unrealistic assertions. The analysis proposed a novel model for understanding the linguistic strategies of persuasive speech in business, highlighting both utilized and potential areas of persuasive speech acts. The implications of these findings extended beyond the specific speeches analyzed, suggesting avenues for further research. Recommendations included exploring persuasion directed at varied audiences, analyzing the perlocutionary effects post-delivery, and integrating paralinguistic and extralinguistic elements with verbal aspects of business speeches. This research not only mapped the current landscape of persuasive strategies in CEO speeches but also opened new possibilities for linguistic exploration in the realm of corporate communication.
Exploring the Interrelated Roles of Text, Author, and Reader in Identity Formation through Literature
Authors: Aquino Charles Jhon , Salvador Roberto
Published: June 2024

This paper explored the interrelated roles of text, author, and reader in the context of identity formation through literature. Engaging with literary sources provides individuals with a unique opportunity to gain a deeper understanding of themselves and others by delving into diverse perspectives, experiences, and narratives. Literature serves as a powerful medium for self-reflection, empathy, and personal growth. Authors' influences shape the text, while readers actively interpret and connect with the content based on their identities. The interactive dialogue between text, author, and reader contributes to the formation of personal and collective identities, expanding our understanding of ourselves and the world around us.
LA ACUMULACIÓN DE LA ACCIÓN CIVIL AL PROCEDIMIENTO PENAL EN CURSO: EFECTOS Y POSIBILIDADES
Authors: Tomás Pla Ángel
Published: June 2024

La presente obra es fruto del VII PROCESSULUS: ENCUENTRO DE JÓVENES INVESTIGADORES EN DERECHO PROCESAL, celebrado los días 19 y 20 de mayo de 2022 en la Universidad Miguel Hernández (previsto para 2020, pero aplazado por la crisis sanitaria ocasionada por el COVID-19). Este evento, que ya se ha organizado en ediciones anteriores en las Universidades de Salamanca, A Coruña, Santander, Cádiz y Cáceres, reúne anualmente a colegas nacionales e internacionales que se inician en la carrera académica dentro del ámbito del Derecho procesal. La exposición pública de los trabajos seleccionados —moderados por reconocidos y consolidados procesalistas— y la reflexión sobre los mismos en el debate generado posteriormente ofrece la garantía de calidad de este libro, dirigido por la profesora Arrabal Platero y coordinado por los profesores Conde Fuentes y García Molina. El lector encontrará en él estudios innovadores y rigurosos que giran en torno a los cuatro ejes temáticos del Congreso: los nuevos retos de la instrucción penal, eficacia, celeridad y resultados del proceso, los desafíos de la justicia en la sociedad digitalizada y cuestiones procesales actuales. La edición y publicación de esta monografía se ha financiado con cargo al proyecto de investigación «RETOS Y RESPUESTAS DEL DERECHO PROCESAL (RRPROC)» concedido por el Vicerrectorado de investigación de la Universidad Miguel Hernández.
LEGITIMACIÓN AMBIENTAL EN EL ORDEN JURISDICICONAL PENAL: NUEVOS RETOS
Authors: Yugueros Prieto Nerea
Published: June 2024

La presente obra es fruto del VII PROCESSULUS: ENCUENTRO DE JÓVENES INVESTIGADORES EN DERECHO PROCESAL, celebrado los días 19 y 20 de mayo de 2022 en la Universidad Miguel Hernández (previsto para 2020, pero aplazado por la crisis sanitaria ocasionada por el COVID-19). Este evento, que ya se ha organizado en ediciones anteriores en las Universidades de Salamanca, A Coruña, Santander, Cádiz y Cáceres, reúne anualmente a colegas nacionales e internacionales que se inician en la carrera académica dentro del ámbito del Derecho procesal. La exposición pública de los trabajos seleccionados —moderados por reconocidos y consolidados procesalistas— y la reflexión sobre los mismos en el debate generado posteriormente ofrece la garantía de calidad de este libro, dirigido por la profesora Arrabal Platero y coordinado por los profesores Conde Fuentes y García Molina. El lector encontrará en él estudios innovadores y rigurosos que giran en torno a los cuatro ejes temáticos del Congreso: los nuevos retos de la instrucción penal, eficacia, celeridad y resultados del proceso, los desafíos de la justicia en la sociedad digitalizada y cuestiones procesales actuales. La edición y publicación de esta monografía se ha financiado con cargo al proyecto de investigación «RETOS Y RESPUESTAS DEL DERECHO PROCESAL (RRPROC)» concedido por el Vicerrectorado de investigación de la Universidad Miguel Hernández.
EFICACIA, CELERIDAD Y OPORTUNIDAD EN EL PROCESO PENAL: REFLEXIONES EN TORNO AL PROCESO POR ACEPTACIÓN DE DECRETO
Authors: Tierno Barrios Selena
Published: June 2024

La presente obra es fruto del VII PROCESSULUS: ENCUENTRO DE JÓVENES INVESTIGADORES EN DERECHO PROCESAL, celebrado los días 19 y 20 de mayo de 2022 en la Universidad Miguel Hernández (previsto para 2020, pero aplazado por la crisis sanitaria ocasionada por el COVID-19). Este evento, que ya se ha organizado en ediciones anteriores en las Universidades de Salamanca, A Coruña, Santander, Cádiz y Cáceres, reúne anualmente a colegas nacionales e internacionales que se inician en la carrera académica dentro del ámbito del Derecho procesal. La exposición pública de los trabajos seleccionados —moderados por reconocidos y consolidados procesalistas— y la reflexión sobre los mismos en el debate generado posteriormente ofrece la garantía de calidad de este libro, dirigido por la profesora Arrabal Platero y coordinado por los profesores Conde Fuentes y García Molina. El lector encontrará en él estudios innovadores y rigurosos que giran en torno a los cuatro ejes temáticos del Congreso: los nuevos retos de la instrucción penal, eficacia, celeridad y resultados del proceso, los desafíos de la justicia en la sociedad digitalizada y cuestiones procesales actuales. La edición y publicación de esta monografía se ha financiado con cargo al proyecto de investigación «RETOS Y RESPUESTAS DEL DERECHO PROCESAL (RRPROC)» concedido por el Vicerrectorado de investigación de la Universidad Miguel Hernández.
MAYORÍAS NECESARIAS PARA INTRODUCIR EN LOS ESTATUTOS SOCIALES LA AUTORIZACIÓN PARA CONVOCAR JUNTAS EXCLUSIVAMENTE TELEMÁTICAS
Authors: Díaz Moreno Alberto
Published: June 2024

La idea de publicar este Libro homenaje parte del XX Congreso Internacional de la Asociación Sainz de Andino, titulado El Derecho mercantil y la pandemia: algunos problemas del pasado, la crisis coyuntural y las perspectivas futuras. El Congreso fue inaugurado por D. Carlos Bermejo Acosta, que dictó la conferencia La política europea de aviación en tiempos de crisis, estando la clausura a cargo de D. Ignacio Tirado Martí, que disertó sobre el Derecho transnacional y tiempos de crisis. Contó, además, con un prestigioso comité científico, que lo es también de la presente obra, integrado por los Dres. Alberto Díaz Moreno, Esperanza Gallego Sánchez, Ángel García Vidal, Rafael Lara González, Carmen Pastor Sempere, José Luis Pérez Serrabona, María Victoria Petit Lavall, Juana Pulgar Ezquerra, Isabel Ramos Herranz, Sonia Rodríguez Sánchez y Daniel Vázquez Albert. Junto a las ponencias que se presentaron en el Congreso, celebrado en la Universidad Pablo de Olavide, en septiembre de 2022, el libro recoge numerosas aportaciones de quienes manifestaron su deseo de contribuir a realizar un reconocimiento al profesor Madrid Parra. En torno a ese tema central, se han agrupado en diversos bloques cuestiones jurídicas muy variadas, pertenecientes a distintos ámbitos del Derecho mercantil, como el Derecho de la Propiedad industrial, el Derecho de la competencia, el Derecho de la publicidad, el Derecho de sociedades, el Derecho de contratos, el Derecho del comercio internacional, el Derecho del transporte, el Derecho del turismo, los servicios de pago y criptoactivos y el Derecho concursal. En casi todos los sectores se han llevado a cabo actuaciones concretas que han supuesto, generalmente, modificaciones transitorias de las normas vigentes o introducción de nuevas normas ad hoc. Y aunque la mayor parte de esos cambios normativos no han tenido especial calado, sí puede decirse que, en ocasiones, se ha evidenciado la necesidad de mirar bajo un nuevo prisma la realidad existente. Eso ha servido tanto para abordar problemas que probablemente, aun detectados, no habían sido afrontados, y retos que, aunque ya pudieran vislumbrarse, habrían evolucionado de una forma más ralentizada de no haberse producido la pandemia. De ahí que, como se infiere del título de la obra, también se plantee en qué medida las reformas realizadas y las tendencias detectadas van más allá de lo coyuntural, de lo inmediato y cómo se está trazando la hoja de ruta de las reformas venideras en ciertos sectores normativos. Se ofrece, de esta manera, una obra que analiza las implicaciones que ha tenido la pandemia en el tráfico jurídico-mercantil, las reacciones del legislador y la posible pervivencia de muchas de las normas ahora adoptadas.
EL DERECHO DE DESISTIMIENTO EN TIEMPOS DE CORONAVIRUS (COVID-19)
Authors: Noval Lamas Joaquín
Published: June 2024

La idea de publicar este Libro homenaje parte del XX Congreso Internacional de la Asociación Sainz de Andino, titulado El Derecho mercantil y la pandemia: algunos problemas del pasado, la crisis coyuntural y las perspectivas futuras. El Congreso fue inaugurado por D. Carlos Bermejo Acosta, que dictó la conferencia La política europea de aviación en tiempos de crisis, estando la clausura a cargo de D. Ignacio Tirado Martí, que disertó sobre el Derecho transnacional y tiempos de crisis. Contó, además, con un prestigioso comité científico, que lo es también de la presente obra, integrado por los Dres. Alberto Díaz Moreno, Esperanza Gallego Sánchez, Ángel García Vidal, Rafael Lara González, Carmen Pastor Sempere, José Luis Pérez Serrabona, María Victoria Petit Lavall, Juana Pulgar Ezquerra, Isabel Ramos Herranz, Sonia Rodríguez Sánchez y Daniel Vázquez Albert. Junto a las ponencias que se presentaron en el Congreso, celebrado en la Universidad Pablo de Olavide, en septiembre de 2022, el libro recoge numerosas aportaciones de quienes manifestaron su deseo de contribuir a realizar un reconocimiento al profesor Madrid Parra. En torno a ese tema central, se han agrupado en diversos bloques cuestiones jurídicas muy variadas, pertenecientes a distintos ámbitos del Derecho mercantil, como el Derecho de la Propiedad industrial, el Derecho de la competencia, el Derecho de la publicidad, el Derecho de sociedades, el Derecho de contratos, el Derecho del comercio internacional, el Derecho del transporte, el Derecho del turismo, los servicios de pago y criptoactivos y el Derecho concursal. En casi todos los sectores se han llevado a cabo actuaciones concretas que han supuesto, generalmente, modificaciones transitorias de las normas vigentes o introducción de nuevas normas ad hoc. Y aunque la mayor parte de esos cambios normativos no han tenido especial calado, sí puede decirse que, en ocasiones, se ha evidenciado la necesidad de mirar bajo un nuevo prisma la realidad existente. Eso ha servido tanto para abordar problemas que probablemente, aun detectados, no habían sido afrontados, y retos que, aunque ya pudieran vislumbrarse, habrían evolucionado de una forma más ralentizada de no haberse producido la pandemia. De ahí que, como se infiere del título de la obra, también se plantee en qué medida las reformas realizadas y las tendencias detectadas van más allá de lo coyuntural, de lo inmediato y cómo se está trazando la hoja de ruta de las reformas venideras en ciertos sectores normativos. Se ofrece, de esta manera, una obra que analiza las implicaciones que ha tenido la pandemia en el tráfico jurídico-mercantil, las reacciones del legislador y la posible pervivencia de muchas de las normas ahora adoptadas.
EL TRATAMIENTO CONCURSAL DE LOS CRÉDITOS DE LAS PERSONAS ESPECIALMENTE RELACIONADAS CON EL DEUDOR EN LA REGULACIÓN DE LA PANDEMIA
Authors: Augoustatos Zarco Nicolás
Published: June 2024

La idea de publicar este Libro homenaje parte del XX Congreso Internacional de la Asociación Sainz de Andino, titulado El Derecho mercantil y la pandemia: algunos problemas del pasado, la crisis coyuntural y las perspectivas futuras. El Congreso fue inaugurado por D. Carlos Bermejo Acosta, que dictó la conferencia La política europea de aviación en tiempos de crisis, estando la clausura a cargo de D. Ignacio Tirado Martí, que disertó sobre el Derecho transnacional y tiempos de crisis. Contó, además, con un prestigioso comité científico, que lo es también de la presente obra, integrado por los Dres. Alberto Díaz Moreno, Esperanza Gallego Sánchez, Ángel García Vidal, Rafael Lara González, Carmen Pastor Sempere, José Luis Pérez Serrabona, María Victoria Petit Lavall, Juana Pulgar Ezquerra, Isabel Ramos Herranz, Sonia Rodríguez Sánchez y Daniel Vázquez Albert. Junto a las ponencias que se presentaron en el Congreso, celebrado en la Universidad Pablo de Olavide, en septiembre de 2022, el libro recoge numerosas aportaciones de quienes manifestaron su deseo de contribuir a realizar un reconocimiento al profesor Madrid Parra. En torno a ese tema central, se han agrupado en diversos bloques cuestiones jurídicas muy variadas, pertenecientes a distintos ámbitos del Derecho mercantil, como el Derecho de la Propiedad industrial, el Derecho de la competencia, el Derecho de la publicidad, el Derecho de sociedades, el Derecho de contratos, el Derecho del comercio internacional, el Derecho del transporte, el Derecho del turismo, los servicios de pago y criptoactivos y el Derecho concursal. En casi todos los sectores se han llevado a cabo actuaciones concretas que han supuesto, generalmente, modificaciones transitorias de las normas vigentes o introducción de nuevas normas ad hoc. Y aunque la mayor parte de esos cambios normativos no han tenido especial calado, sí puede decirse que, en ocasiones, se ha evidenciado la necesidad de mirar bajo un nuevo prisma la realidad existente. Eso ha servido tanto para abordar problemas que probablemente, aun detectados, no habían sido afrontados, y retos que, aunque ya pudieran vislumbrarse, habrían evolucionado de una forma más ralentizada de no haberse producido la pandemia. De ahí que, como se infiere del título de la obra, también se plantee en qué medida las reformas realizadas y las tendencias detectadas van más allá de lo coyuntural, de lo inmediato y cómo se está trazando la hoja de ruta de las reformas venideras en ciertos sectores normativos. Se ofrece, de esta manera, una obra que analiza las implicaciones que ha tenido la pandemia en el tráfico jurídico-mercantil, las reacciones del legislador y la posible pervivencia de muchas de las normas ahora adoptadas.
LUCHA CONTRA LA CORRUPCIÓN EN EL SECTOR SALUD
Authors: Borráez Gaona Oswaldo
Published: June 2024

A lo largo de esta obra el lector podrá observar las distintas manifestaciones de la corrupción en entornos tan diversos como los sistemas de salud, el sector privado, la contratación pública o la gestión de desastres y el impacto de sus nefastas consecuencias; pero al mismo tiempo podrá advertir la variedad de mecanismos a través de los cuales se hace frente a este fenómeno: agencias estatales anticorrupción, inversión en I+D, uso de la inteligencia artificial, instituciones como el decomiso y la posibilidad de evitar el ciberblanqueo, además de los sistemas de control administrativo de los contratos públicos y el mapeo de riesgos. Las perspectivas y ámbitos en los que se desarrollan los capítulos de este trabajo dan cuenta de la extensión y alcances de la corrupción y de las numerosas posibilidades y alternativas para lidiar con ella. Esta obra aglutina múltiples aproximaciones a un tema que debe resultar de interés general porque ocasiona la disparidad en la asignación de recursos y permite que la brecha entre pobreza y riqueza se ensanche con facilidad.
Integritas Kepemimpinan Pastoral di Era Postmodern Menurut 2 Timotius 2:14-25
Authors: Hananto Tri , Adi Didit Yuliantono
Published: June 2024

The development of technology and information in the global era will have a major influence on human life. Modernist culture has become the choice of the wider community over conventional cultures. Sometimes society loses the social glue that has been the root of culture, which is replaced with the emergence of social media. Apart from that, the development of this technology also has a bad influence on moral ethics, norms and rules in society. However, this development also provides positive insight into the emergence of new leaders, especially leaders in the spiritual world or pastoral leaders who must maintain their integrity. The methodology in this writing uses an exposition approach by paying attention to the verses of God's word contained in 2 Tim 2:14-25, to get practical application from the figure of a pastoral leader with integrity who keeps his life in accordance with the truth of God's word and by asking for the guidance of the Holy Spirit so that he can protect accountability which has a good influence in the postmodern world.
Peran Nilai-Nilai Islam dalam Kewirausahaan Sosial: Studi Komparatif Pengusaha Muslim dan Non-Muslim
Authors: Agus Setiawan Muhammad , Haseena Armina Sheema , Reyhan Muhammad
Published: June 2024

This research explores the role of Islamic values in social entrepreneurship by comparing the ethos, motivations, and practices of Muslim and non-Muslim entrepreneurs. The aim is to understand how religious beliefs influence entrepreneurial behavior in the context of creating positive social change. This research uses qualitative methods with case studies on Muslim and non-Muslim entrepreneurs involved in various fields of social entrepreneurship. Data were collected through in-depth interviews and participant observation. The results showed that Islamic values such as justice, generosity, and social responsibility play an important role in motivating and guiding Muslim entrepreneurs in their activities. Muslim entrepreneurs have a strong commitment to helping communities and creating positive social change. However, there are some differences in ethos and practice between Muslim and non-Muslim entrepreneurs. Muslim entrepreneurs are more likely to emphasize the importance of business ethics and moral values in running their business. This research makes an important contribution to understanding the role of religion in social entrepreneurship. The results of this study show that Islamic values can be a source of inspiration and motivation for Muslim entrepreneurs to create positive social change.
Keywords : Social Entrepreneurship, Islamic Values, Business Ethics, Motivation, Social Change.
Genotyping of red tilapia strains in Central Luzon Philippines targeting ESR1 gene
Authors: de Guia Arren Christian , Judan Cruz Khristina , Almuete Karl Danielle , Uy Mary Rose
Published: June 2024

Tilapia is an economically important commodity worldwide. Marker-assisted selection (MAS) has been practiced in livestock culture to ensure the selection of a specific trait that will benefit the culture system. This study assessed the allelic variation in six red tilapia strains in Central Luzon, Philippines. Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) was done to evaluate the genotypes of six strains of red tilapia using intron one portion of the chromosome one of the estrogen receptor 1 (ESR1) gene. The target gene was amplified using primers designed in previous study and then subjected to RFLP using PvuII restriction enzyme. Single Nucleotide Polymorphisms (SNPs) were also evaluated in six DNA sequences. Results showed that 18 red tilapia samples were found to be of the AA genotype. Aligned sequences of the 122 bp ESR1 gene revealed that among six red tilapia strains, there are 117 identical pairs, three transversional pairs, and three transitional pairs. The SNPs observed can be used to identify restriction enzymes that discriminate different genotypes in the target gene. Association studies can be done to determine the genotypes that are linked to specific traits in cultured animals.
Incidence of ghost nets in the Tioman Island Marine Park of Malaysia
Authors: Chelliah Alvin , Chen Sue , Yaman Shahir , Dolorosa Roger
Published: June 2024

Ghost nets are major contributor to ocean pollution with extensive social, economic and environmental impacts. Ghost nets trap marine life, build up sediment, and smother and damage sensitive bottom habitats such as coral reefs and seagrass beds. Data on ghost nets are widely available for many coastal locations but there has been very limited information from Malaysia specifically Tioman Island. In 2015, Reef Check Malaysia started training local islanders to locate and remove ghost nets from reefs and beaches around Tioman Island. A reporting hotline was set up to gather information on ghost nets. Once vital information was gathered, the local islanders retrieved them and recorded the ghost nets and sent them for proper disposal. A total of 145 ghost nets weighing over 21 t were retrieved from Tioman Island from 2016 to 2022. The volume of ghost nets retrieved showed an increasing trend and were often found in March, April and September. The ghost nets originated from fishermen operating illegally inside the marine protected area (MPA) and legal fishermen operating outside the MPA. Ghost nets find their way to Tioman Island with strong currents and monsoonal winds. Most of the ghost nets retrieved were inside the MPA and on the western side of Tioman Island. Higher human population, shallower waters, shoreline morphology, dominant coral growth design and reef rugosity on the western side of Tioman Island are reasons for higher ghost nets sightings, thus retrieval and management efforts should focus on this side.
PENINGKATAN KAPASITAS PENANGANAN KEGAWATDARURATAN DENGAN KASUS PATAH TULANG (FRAKTUR) PADA REMAJA
Authors: Mar'athus Nasokha Ildsa Maulidya , Utami Asih Puji , Anggraeni Ari , Fadhila Hafidzoh Q. , Triwahyuningsih Aprillia , Salsabila Shelvira , Nugroho Anshor
Published: June 2024

One of the most common consequences of a traffic accident is a femur fracture. Those fractures can cause bleeding, internal organ injury, wound infection, respiratory syndrome and disability. Several studies state that the age range of 16-20 years old has the most traffic accidents and fractures. A fracture is a disturbance of the normal continuity of a bone, if a fracture occurs, the surrounding soft tissue is also often disturbed. Radiographs (s-rays) can show bone injuries but are unable to show torn muscles or ligaments, severed nerves, or broken blood vessels which can complicate the client’s recovery. An open fracture is a condition where fragments are or have been in contact with the outside world (Black and Hawks, 2014). Inspection for a fracture by looking for swelling, visible bone protruding from soft tissue. Treatment in general in this emergency situation, one which is to immobilize the fracture with support, bandage or splint. Efforts to improve students’ skills in handling
TRANSFORMASI DIGITAL DALAM PENGELOLAAN WAKAF UANG (PELATIHAN UNTUK KAUM MUDA SEDANAU, NATUNA, KEPULAUAN RIAU)
Authors: Miftahuddin  , Herliyanto Muci , Adam Orista Miranti Irpada
Published: June 2024

Terbitnya Peraturan Menteri Agama Nomor 1 Tahun 2022 tentang Pengelolaan dan Pengembangan Wakaf Uang Melalui Cash Waqf Linked Sukuk merupakan indikasi telah terjadinya perkembangan yang pesat dalam pengelolaan wakaf uang di Indonesia.  Peraturan ini, dan beberapa peraturan lain sebelumnya, secara strategis hadir dengan maksud untuk menjawab tantangan pengelolaan keuangan syariah secara modern. Ini merupakan bagian langkah strategis untuk memanfaatkan inovasi teknologi yang telah mendorong fenomena digitalisasi di berbagai bidang, termasuk dalam perwakafan. Pemanfaatan teknologi digital dalam pengelolaan wakaf sudah dilakukan mulai dari tahap pengumpulan sampai pelaporan pemanfaatan wakaf. Meski demikian, karena platform digital ini masih baru, perlu dilakukan peningkatan pemahaman dan kesadaran masyarakat untuk berwakaf secara digital, melalui sosialisasi, literasi dan edukasi. Pengabdian Masyarakat Prodi HPI STAI Natuna bermaksud melakukan sosialisasi, literasi dan edukasi masyarakat terkait pemanfaatan platform digital dalam pengelolaan wakaf uang. Kegiatan juga dimaksudkan untukmendorong partisipasi masyarakat, khusunya dalam mengawasi pengelolaan wakaf uang, baik pada tahap penggalangan dana, investasi wakaf tunai, maupun distribusi hasil investasi wakaf tunai.
SWOT ANALYSIS IN THE DEVELOPMENT OF CULTURAL VILLAGE-BASED TOURISM VILLAGES
Authors: Yurnalis Festria Anita , Mustiqowati Ummul Fithriyyah
Published: June 2024

The purpose of this study is to determine the most suitable development strategy for a tourism village based on cultural villages in Nagari Jawi-jawi. This qualitative descriptive study uses SWOT analysis to collect data from informants. The author uses observations, interviews, and documentation with research informants, including the Tourism and Culture Office of Solok Regency, Wali Nagari Jawi-jawi, Nagarai Jawi-jawi Tourism Awareness Group, and important figures. The results of this study state that the Nagari Jawi-jawi cultural village has a lot of natural, cultural and man-made potential that can be developed to improve the Nagari Jawi-jawi economy and increase people's income. One approach that can be used based on the SWOT analysis is to provide attractive and unique tour package solutions with the aim of being different from other similar tourist villages. However, in its development there are obstacles in the form of lack of public awareness, limited funds and also low competitiveness.
MANAGEMENT OF HAJJ SERVICES AT THE OFFICE OF THE MINISTRY OF RELIGIOUS AFFAIRS OF NORTH BENGKULU REGENCY
Authors: Anugerah Jerri Nopriyan , Noviyanto Hernowo , Gembar Mulyadi
Published: June 2024

This type of research is qualitative research with the research approach using Management and psychology. At the same time, the informants in this study are the Head of the Hajj and Umrah Organizing Section, the Staff of the Hajj and Umrah Organizing Section, namely: 1) How is the management of Hajj services at the office of the Ministry of Religion of North Bengkulu Regency. 2) What are the supporting and inhibiting factors in hajj services at the Office of the Ministry of Religion of North Bengkulu Regency? The results of the study show that the management of the services of pilgrims at the Office of the Ministry of Religion of North Bengkulu starts from planning, organizing, implementing, and supervising activities in collaboration with Government Institutions that help the successful implementation of the pilgrimage. The forms of services provided at the North Bengkulu Ministry of Religion Office include Hajj registration services, Hajj cancellation, proposals for elderly pilgrims, merging of mahrams who register separately, guidance on Hajj rituals, division of groups and groups as well as protection services for pilgrims. The inhibiting factors encountered can be overcome by having supporting factors in providing services to prospective pilgrims
Air Traffic Scenario Evaluation Based on Metric Learning
Authors: SUI Dong , LI Qian , ZHOU Tingting , LIU Kechen
Published: June 2024

Air traffic scenario evaluation can support the optimisation of traffic flow and airspace configuration to improve the safety of air traffic control. Since the air traffic scenario is influenced by the interaction of multiple factors, and real labelled data are lacking, the feature index selection and scenario evaluation are challenging endeavours. In this study, indicators were selected from three dimensions: airspace structure, traffic characteristics and meteorological conditions. The evaluation indicators were quantitatively screened according to information importance and overlap. Utilising the flow control and traffic flow information, the authors defined the free and saturated states of the state interval and developed a metric-based learning method to calibrate the state samples. A multilayer perceptron regression model was employed to establish the mapping relationship between the feature indicators and air traffic scenario. The evaluation accuracy of the sample set from three sectors in Shanghai exceeded 80%, which verified the effectiveness of the scenario evaluation model. This contribution holds practical significance in enhancing the safety of airspace operations.
An Alternative Optimal Design of Dynamic Straight-Right Lane Control for T-Shaped Intersections
Authors: HAN Yin , NING Bo , LIANG Shidong
Published: June 2024

A novel control method called dynamic straight-right lane (DSRL) control design is proposed for signalised intersections. This design aims to utilise the resources of the right-turn lane to increase the capacity for straight-through traffic while minimising the impact on right-turn vehicles. In this paper, an alternative approach to DSRL control design for T-shaped intersections is proposed. By redesigning the spatial and temporal allocation at the entrance, this design ensures the safety of lane change manoeuvres and reduces the design threshold for T-shaped intersections. To facilitate the implementation of the DSRL control design, a cellular automata model is constructed. Additionally, a case study is conducted, leading to the identification of the optimal design parameters for DSRL control. The proposed DSRL control design is compared with two conventional control designs, namely dedicated right-turn lane control design and static straight-right lane control design, in various geometric and traffic demand scenarios. The findings reveal that the T-shaped intersection, when equipped with a dedicated right-turn lane control design, can achieve a maximum delay optimisation rate of 91% by adopting the DSRL control design. Similarly, the T-shaped intersection, with a static straight-right lane control design, can attain a maximum delay optimisation rate of 84% when employing the DSRL control design.
Operating Vehicles’ Speed Prediction Models
Authors: VERTLBERG Juraj Leonard , ŠVAJDA Marko , JAKOVLJEVIĆ Marijan , ŠEVROVIĆ Marko
Published: June 2024

Vehicle speed is one of the main factors that influence the occurrence and severity of the consequences of road traffic accidents. Operating speed can be defined, among other things, as the actual speed at which the largest number of road users drive in conditions of free traffic flow. It can be measured on existing roads, however, on newly designed roads it can only be predicted. For this reason, many researchers have examined the correlation between the elements of the road as well as its surroundings and operating speed. By determining the correlation, models for predicting operating speed were created. As part of this paper, the most significant models for predicting operating speed were analysed. Of course, the largest number of models are stochastic, but in recent years, models based on artificial intelligence, more precisely on deep learning, have also been created. Accordingly, the goal of this paper is to review the model for predicting the operating speed of vehicles while identifying opportunities for further research and improvement in this area.
Discovery of runs-of-homozygosity diplotype clusters and their associations with diseases in UK Biobank
Authors: Naseri Ardalan , Zhi Degui , Zhang Shaojie
Published: June 2024

Runs-of-homozygosity (ROH) segments, contiguous homozygous regions in a genome were traditionally linked to families and inbred populations. However, a growing literature suggests that ROHs are ubiquitous in outbred populations. Still, most existing genetic studies of ROH in populations are limited to aggregated ROH content across the genome, which does not offer the resolution for mapping causal loci. This limitation is mainly due to a lack of methods for the efficient identification of shared ROH diplotypes. Here, we present a new method, ROH-DICE (runs-of-homozygous diplotype cluster enumerator), to find large ROH diplotype clusters, sufficiently long ROHs shared by a sufficient number of individuals, in large cohorts. ROH-DICE identified over 1 million ROH diplotypes that span over 100 single nucleotide polymorphisms (SNPs) and are shared by more than 100 UK Biobank participants. Moreover, we found significant associations of clustered ROH diplotypes across the genome with various self-reported diseases, with the strongest associations found between the extended human leukocyte antigen (HLA) region and autoimmune disorders. We found an association between a diplotype covering the homeostatic iron regulator (HFE) gene and hemochromatosis, even though the well-known causal SNP was not directly genotyped or imputed. Using a genome-wide scan, we identified a putative association between carriers of an ROH diplotype in chromosome 4 and an increase in mortality among COVID-19 patients (p-value = 1.82 × 10−11). In summary, our ROH-DICE method, by calling out large ROH diplotypes in a large outbred population, enables further population genetics into the demographic history of large populations. More importantly, our method enables a new genome-wide mapping approach for finding disease-causing loci with multi-marker recessive effects at a population scale.
The Alk receptor tyrosine kinase regulates Sparkly, a novel activity regulating neuropeptide precursor in the Drosophila central nervous system
Authors: Sukumar Sanjay Kumar , Antonydhason Vimala , Molander Linnea , Sandakly Jawdat , Kleit Malak , Umapathy Ganesh , Mendoza-Garcia Patricia , Masudi Tafheem , Schlosser Andreas , Nässel Dick R , Wegener Christian , Shirinian Margret , Palmer Ruth H
Published: June 2024

Numerous roles for the Alk receptor tyrosine kinase have been described in Drosophila, including functions in the central nervous system (CNS), however the molecular details are poorly understood. To gain mechanistic insight, we employed Targeted DamID (TaDa) transcriptional profiling to identify targets of Alk signaling in the larval CNS. TaDa was employed in larval CNS tissues, while genetically manipulating Alk signaling output. The resulting TaDa data were analyzed together with larval CNS scRNA-seq datasets performed under similar conditions, identifying a role for Alk in the transcriptional regulation of neuroendocrine gene expression. Further integration with bulk and scRNA-seq datasets from larval brains in which Alk signaling was manipulated identified a previously uncharacterized Drosophila neuropeptide precursor encoded by CG4577 as an Alk signaling transcriptional target. CG4577, which we named Sparkly (Spar), is expressed in a subset of Alk-positive neuroendocrine cells in the developing larval CNS, including circadian clock neurons. In agreement with our TaDa analysis, overexpression of the Drosophila Alk ligand Jeb resulted in increased levels of Spar protein in the larval CNS. We show that Spar protein is expressed in circadian (clock) neurons, and flies lacking Spar exhibit defects in sleep and circadian activity control. In summary, we report a novel activity regulating neuropeptide precursor gene that is regulated by Alk signaling in the Drosophila CNS.
Coordinated molecular and ecological adaptations underlie a highly successful parasitoid
Authors: Pang Lan , Fang Gangqi , Liu Zhiguo , Dong Zhi , Chen Jiani , Feng Ting , Zhang Qichao , Sheng Yifeng , Lu Yueqi , Wang Ying , Zhang Yixiang , Li Guiyun , Chen Xuexin , Zhan Shuai , Huang Jianhua
Published: June 2024

The success of an organism depends on the molecular and ecological adaptations that promote its beneficial fitness. Parasitoids are valuable biocontrol agents for successfully managing agricultural pests, and they have evolved diversified strategies to adapt to both the physiological condition of hosts and the competition of other parasitoids. Here, we deconstructed the parasitic strategies in a highly successful parasitoid, Trichopria drosophilae, which parasitizes a broad range of Drosophila hosts, including the globally invasive species D. suzukii. We found that T. drosophilae had developed specialized venom proteins that arrest host development to obtain more nutrients via secreting tissue inhibitors of metalloproteinases (TIMPs), as well as a unique type of cell—teratocytes—that digest host tissues for feeding by releasing trypsin proteins. In addition to the molecular adaptations that optimize nutritional uptake, this pupal parasitoid has evolved ecologically adaptive strategies including the conditional tolerance of intraspecific competition to enhance parasitic success in older hosts and the obligate avoidance of interspecific competition with larval parasitoids. Our study not only demystifies how parasitoids weaponize themselves to colonize formidable hosts but also provided empirical evidence of the intricate coordination between the molecular and ecological adaptations that drive evolutionary success.
Senescent cells inhibit muscle differentiation via the SASP-lipid 15d-PGJ2 mediated modification and control of HRas
Authors: Pundlik Swarang Sachin , Barik Alok , Venkateshvaran Ashwin , Sahoo Snehasudha Subhadarshini , Jaysingh Mahapatra Anshuman , Math Raviswamy G H , Ramanathan Arvind
Published: June 2024

Senescent cells, which are characterized by multiple features such as increased expression of Senescence-Associated β-galactosidase activity (SA β-gal) and cell cycle inhibitors such as p21 or p16, accumulate with tissue damage and dysregulate tissue homeostasis. In the context of skeletal muscle, it is known that agents used for chemotherapy such as Doxorubicin cause buildup of senescent cells, leading to the inhibition of tissue regeneration. Senescent cells influence the neighboring cells via numerous secreted factors which form the senescence-associated secreted phenotype (SASP). Lipids are emerging as a key component of SASP that can control tissue homeostasis. Arachidonic acid-derived lipids have been shown to accumulate within senescent cells, specifically 15d-PGJ
2
, which is an electrophilic lipid produced by the non-enzymatic dehydration of the prostaglandin PGD
2
. In this study, we show that 15d-PGJ
2
is also released by Doxorubicin-induced senescent cells as a SASP factor. Treatment of skeletal muscle myoblasts with the conditioned medium from these senescent cells inhibits myoblast fusion during differentiation. Inhibition of L-PTGDS, the enzyme that synthesizes PGD
2
, diminishes the release of 15d-PGJ
2
by senescent cells and restores muscle differentiation. We further show that this lipid post-translationally modifies Cys184 of HRas in skeletal muscle cells, causing a reduction in the localization of HRas to the Golgi, increased HRas binding to RAF RBD, and activation of cellular MAPK-Erk signaling (but not the Akt signaling). Mutating C184 of HRas prevents the ability of 15d- PGJ
2
to inhibit the differentiation of muscle cells and control the activity of HRas. This work shows that 15d-PGJ
2
released from senescent cells could be targeted to restore muscle homeostasis after chemotherapy.
Benchmarking tRNA-Seq quantification approaches by realistic tRNA-Seq data simulation identifies two novel approaches with higher accuracy
Authors: Smith Tom , Monti Mie , Willis Anne E , Kalmár Lajos
Published: June 2024

Quantification of transfer RNA (tRNA) using illumina sequencing based tRNA-Seq is complicated by their degree of redundancy and extensive modifications. As such, no tRNA-Seq method has become well established, while various approaches have been proposed to quantify tRNAs from sequencing reads. Here, we use realistic tRNA-Seq simulations to benchmark tRNA-Seq quantification approaches, including two novel approaches. We demonstrate that these novel approaches are consistently the most accurate, using data simulated to mimic five different tRNA-Seq methods. This simulation-based benchmarking also identifies specific shortfalls for each quantification approach and suggests that up to 13% of the variance observed between cell lines in real tRNA-Seq data could be due to systematic differences in quantification accuracy.
Human immunodeficiency virus-1 induces and targets host genomic R-loops for viral genome integration
Authors: Park Kiwon , Lee Dohoon , Jeong Jiseok , Lee Sungwon , Kim Sun , Ahn Kwangseog
Published: June 2024

Although HIV-1 integration sites are considered to favor active transcription units in the human genome, high-resolution analysis of individual HIV-1 integration sites have shown that the virus can integrate in a variety of host genomic locations, including non-genic regions. The invisible infection by HIV-1 integrating into non-genic regions challenging the traditional understanding of HIV-1 integration site selection are rather more problematic as they are selected to preserve in the host genome during prolonged antiretroviral therapies. Here, we showed that HIV-1 targets R-loops, a genomic structure made up of DNA–RNA hybrids, for integration. HIV-1 initiates the formation of R-loops in both genic and non-genic regions of the host genome and preferentially integrates into R-loop-rich regions. Using a cell model that can independently control transcriptional activity and R-loop formation, we demonstrated that the formation of R-loops directs HIV-1 integration targeting sites. We also found that HIV-1 integrase proteins physically bind to the host genomic R-loops. These findings provide fundamental insights into the mechanisms of retroviral integration and the new strategies of antiretroviral therapy against HIV-1 latent infection.
T follicular helper cell profiles differ by malaria antigen and for children compared to adults
Authors: Forconi Catherine S. , Nixon Christina , Wu Hannah W. , Odwar Boaz , Pond-Tor Sunthorn , Ong’echa John M. , Kurtis Jonathan , Moormann Ann M.
Published: June 2024

Circulating T-follicular helper (cT
FH
) cells have the potential to provide an additional correlate of protection against
Plasmodium falciparum
(
Pf)
as they are essential to promote B cell production of long-lasting antibodies. Assessing the specificity of cT
FH
subsets to individual malaria antigens is vital to understanding the variation observed in antibody responses and identifying promising malaria vaccine candidates.Using spectral flow cytometry and unbiased clustering analysis we assessed antigen-specific cT
FH
cell recall responses
in vitro
to malaria vaccine candidates
Pf
SEA-1A and
Pf
GARP within a cross-section of children and adults living in a malaria holoendemic region of western Kenya.In children, a broad array of cT
FH
subsets (defined by cytokine and transcription factor expression) were reactive to both malaria antigens,
Pf
SEA-1A and
Pf
GARP, while adults had a narrow profile centering on cT
FH
17- and cT
FH
1/17-like subsets following stimulation with
Pf
GARP only.Because T
FH
17 cells are involved in the maintenance of memory antibody responses within the context of parasitic infections, our results suggest that
Pf
GARP might generate longer lived antibody responses compared to
Pf
SEA-1A. These findings have intriguing implications for evaluating malaria vaccine candidates as they highlight the importance of including cT
FH
profiles when assessing interdependent correlates of protective immunity.
Ais: streamlining segmentation of cryo-electron tomography datasets
Authors: Last Mart G.F. , Abendstein Leoni , Voortman Lenard M. , Sharp Thomas H.
Published: June 2024

Segmentation is a critical data processing step in many applications of cryo-electron tomography. Downstream analyses, such as subtomogram averaging, are often based on segmentation results, and are thus critically dependent on the availability of open-source software for accurate as well as high-throughput tomogram segmentation. There is a need for more user-friendly, flexible and comprehensive segmentation software that offers an insightful overview of all steps involved in preparing automated segmentations. Here, we present Ais: a dedicated tomogram segmentation package that is geared towards both high performance and accessibility, available at github.com/bionanopatterning/Ais. In this report, we demonstrate two common processing steps that can be greatly accelerated with Ais: particle picking for subtomogram averaging, and generating many-feature models of cellular architecture based on
in situ
tomography data. Featuring comprehensive annotation, segmentation, and rendering functionality, as well as an open repository for trained models at aiscryoet.org, we hope that Ais will help accelerate research and dissemination of data involving cryoET.