bluuebunny/crossref_metadata_2025 huggingface dataset:
Insights into brain tumor diagnosis: exploring in situ hybridization techniques
Authors: Namiot E. D. , Zembatov G. M. , Tregub P. P.
Published: July 2024

Objectives

Diagnosing brain tumors is critical due to their complex nature. This review explores the potential of in situ hybridization for diagnosing brain neoplasms, examining their attributes and applications in neurology and oncology.

Methods

The review surveys literature and cross-references findings with the OMIM database, examining 513 records. It pinpoints mutations suitable for in situ hybridization and identifies common chromosomal and gene anomalies in brain tumors. Emphasis is placed on mutations’ clinical implications, including prognosis and drug sensitivity.

Results

Amplifications in EGFR, MDM2, and MDM4, along with Y chromosome loss, chromosome 7 polysomy, and deletions of PTEN, CDKN2/p16, TP53, and DMBT1, correlate with poor prognosis in glioma patients. Protective genetic changes in glioma include increased expression of ADGRB3/1, IL12B, DYRKA1, VEGFC, LRRC4, and BMP4. Elevated MMP24 expression worsens prognosis in glioma, oligodendroglioma, and meningioma patients. Meningioma exhibits common chromosomal anomalies like loss of chromosomes 1, 9, 17, and 22, with specific genes implicated in their development. Main occurrences in medulloblastoma include the formation of isochromosome 17q and SHH signaling pathway disruption. Increased expression of BARHL1 is associated with prolonged survival. Adenomas mutations were reviewed with a focus on adenoma-carcinoma transition and different subtypes, with MMP9 identified as the main metalloprotease implicated in tumor progression.

Discussion

Molecular-genetic diagnostics for common brain tumors involve diverse genetic anomalies. In situ hybridization shows promise for diagnosing and prognosticating tumors. Detecting tumor-specific alterations is vital for prognosis and treatment. However, many mutations require other methods, hindering in situ hybridization from becoming the primary diagnostic method.
KATP channels in cerebral hemodynamics: a systematic review of preclinical and clinical studies
Authors: Daoud Hassan Ali Suleiman , Kokoti Lili , Al-Karagholi Mohammad Al-Mahdi
Published: July 2024

Cumulative evidence suggests that ATP-sensitive potassium (KATP) channels act as a key regulator of cerebral blood flow (CBF). This implication seems to be complicated, since KATP channels are expressed in several vascular-related structures such as smooth muscle cells, endothelial cells and pericytes. In this systematic review, we searched PubMed and EMBASE for preclinical and clinical studies addressing the involvement of KATP channels in CBF regulation. A total of 216 studies were screened by title and abstract. Of these, 45 preclinical and 6 clinical studies were included. Preclinical data showed that KATP channel openers (KCOs) caused dilation of several cerebral arteries including pial arteries, the middle cerebral artery and basilar artery, and KATP channel inhibitor (KCI) glibenclamide, reversed the dilation. Glibenclamide affected neither the baseline CBF nor the baseline vascular tone. Endothelium removal from cerebral arterioles resulted in an impaired response to KCO/KCI. Clinical studies showed that KCOs dilated cerebral arteries and increased CBF, however, glibenclamide failed to attenuate these vascular changes. Endothelial KATP channels played a major role in CBF regulation. More studies investigating the role of KATP channels in CBF-related structures are needed to further elucidate their actual role in cerebral hemodynamics in humans.

Systematic review registration: Prospero: CRD42023339278 (preclinical data) and CRD42022339152 (clinical data).
The association between the size of adipocyte-derived extracellular vesicles and fasting serum triglyceride-glucose index as proxy measures of adipose tissue insulin resistance in a rat model of early-stage obesity
Authors: Delgadillo-Velázquez Jaime , Alday Efrain , Aguirre-García María Magdalena , Canett-Romero Rafael , Astiazaran-Garcia Humberto
Published: July 2024

Introduction

Obesity is a complex disease that predisposes individuals to cardiometabolic alterations. It leads to adipose tissue (AT) dysfunction, which triggers insulin resistance (IR). This suggests that people with obesity develop local IR first and systemic IR later. AT secretes extracellular vesicles, which may be physiopathologically associated with the development of IR. Our aim was to evaluate the effect of a high-fat diet on different parameters of adiposity in a rat model of early-stage obesity and to determine if these parameters are associated with markers of systemic IR. In addition, we sought to explore the relationship between fasting blood measures of IR (Triglycerides/High Density Lipoprotein-cholesterol [TAG/HDL-c] and Triglycerides-Glucose Index [TyG Index]) with the size of adipocyte-derived extracellular vesicles (adEV).

Methods

We used a model of diet-induced obesity for ten weeks in Wistar rats exposed to a high-fat diet. Final weight gain was analyzed by Dual X-ray absorptiometry. Visceral obesity was measured as epididymal AT weight. IR was evaluated with fasting TyG Index & TAG/HDL-c, and adEV were isolated from mature adipocytes on ceiling culture.

Results

In the high-fat diet group, glucose and triglyceride blood concentrations were higher in comparison to the control group (Log2FC, 0.5 and 1.5 times higher, respectively). The values for TyG Index and adEV size were different between the control animals and the high-fat diet group. Multiple linear regression analyses showed that adEV size can be significantly associated with the TyG Index value, when controlling for epididymal AT weight.

Conclusion

Our results show that lipid and glucose metabolism, as well as the size and zeta potential of adEV are already altered in early-stage obesity and that adEV size can be significantly associated with liver and systemic IR, estimated by TyG Index.
Association of the Healthy Dietary Index 2020 and its components with chronic respiratory disease among U.S. adults
Authors: Zhiyi Liu , Shuhan Zhou , Libing Zhang , Jiaqi Li , Xin Ding , Lingxi Qin , Yuan-Mei Shi , Hong Zhang , Jiaqi Nie , Hui Li , Sanyou Fang
Published: July 2024

Background

Chronic respiratory disease is an important public health problem in the United States and globally. Diet, an important part of a healthy lifestyle, is also relevant to chronic respiratory health. We aimed to explore the relationship between overall dietary quality and the risk of chronic respiratory disease (CRD), include chronic bronchitis (CB), emphysema and asthma.

Method

A total of 4,499 United States adults were extracted from the National Health and Nutrition Examination Survey (NHANES) in 2017–2018. Diet quality was assessed using 2 day, 24 h dietary recall data and quantified as the Healthy Diet Index (HEI)-2020 score. Binary logistic regression models, restricted cubic splines (RCS) and generalized additive modeling (GAM), the weighted quartile sum (WQS) and qgcom models were used to assess the relationship between HEI-2020 scores and risk of CB, emphysema and asthma.

Results

High HEI-2020 scores are associated with low risk of chronic respiratory disease (CB: 0.98, 0.97–0.99; emphysema: 0.98, 0.97–0.99; asthma: 0.98, 0.97–0.99) and consistent results across different dietary variable categorization (Tertile: CB: 0.58, 0.42–0.81; asthma: 0.51, 0.35–0.74; Quartile: CB: 0.57, 0.34–0.97; asthma: 0.56, 0.36–0.86) and different weighting models. Negative dose-response relationship between dietary quality and risk of chronic respiratory disease also shown in RCS and GAM models. The WQS and qgcom models also showed a healthy mixing effect of dietary components on respiratory disease, with high-quality proteins, vegetables, and fruits making the heaviest contributions.

Conclusion

Higher HEI-2020 scores were associated with lower risk of CB, emphysema, and asthma. Following Dietary Guidelines for Americans 2020–2025 could support enhanced respiratory health.
The metabolites from traditional Chinese medicine targeting ferroptosis for cancer therapy
Authors: Tang Yu , Zhuang Ying , Zhao Chuanxiang , Gu Shuangshuang , Zhang Junya , Bi Shiqi , Wang Ming , Bao Lei , Li Mei , Zhang Wei , Zhu Liqun
Published: July 2024

Cancer is a major disease with ever-increasing morbidity and mortality. The metabolites derived from traditional Chinese medicine (TCM) have played a significant role in combating cancers with curative efficacy and unique advantages. Ferroptosis, an iron-dependent programmed death characterized by the accumulation of lipid peroxide, stands out from the conventional forms of cell death, such as apoptosis, pyroptosis, necrosis, and autophagy. Recent evidence has demonstrated the potential of TCM metabolites targeting ferroptosis for cancer therapy. We collected and screened related articles published in or before June 2023 using PubMed, Google Scholar, and Web of Science. The searched keywords in scientific databases were ferroptosis, cancer, tumor, traditional Chinese medicine, botanical drugs, and phytomedicine. Only research related to ferroptosis, the metabolites from TCM, and cancer was considered. In this review, we introduce an overview of the current knowledge regarding the ferroptosis mechanisms and review the research advances on the metabolites of TCM inhibiting cancer by targeting ferroptosis.
Mechanistic elucidation of ferroptosis and ferritinophagy: implications for advancing our understanding of arthritis
Authors: Guo Caopei , Peng Jiaze , Cheng Piaotao , Yang Chengbing , Gong Shouhang , Zhang Lin , Zhang Tao , Peng Jiachen
Published: July 2024

In recent years, the emerging phenomenon of ferroptosis has garnered significant attention as a distinctive mode of programmed cell death. Distinguished by its reliance on iron and dependence on reactive oxygen species (ROS), ferroptosis has emerged as a subject of extensive investigation. Mechanistically, this intricate process involves perturbations in iron homeostasis, dampening of system Xc-activity, morphological dynamics within mitochondria, and the onset of lipid peroxidation. Additionally, the concomitant phenomenon of ferritinophagy, the autophagic degradation of ferritin, assumes a pivotal role by facilitating the liberation of iron ions from ferritin, thereby advancing the progression of ferroptosis. This discussion thoroughly examines the detailed cell structures and basic processes behind ferroptosis and ferritinophagy. Moreover, it scrutinizes the intricate web of regulators that orchestrate these processes and examines their intricate interplay within the context of joint disorders. Against the backdrop of an annual increase in cases of osteoarthritis, rheumatoid arthritis, and gout, these narrative sheds light on the intriguing crossroads of pathophysiology by dissecting the intricate interrelationships between joint diseases, ferroptosis, and ferritinophagy. The newfound insights contribute fresh perspectives and promising therapeutic avenues, potentially revolutionizing the landscape of joint disease management.
Well-being in parents of children with cancer: illness perceptions’ mediating role for hope and social support
Authors: Schwartz-Attias Irit , Krulik Tamar , Ronen Tammie
Published: July 2024

Introduction

Parents of children with cancer may experience enormous physical and emotional pressures. During such times, perception of the situation can be important in mediating the link between one’s basic resources (mainly cognitive and social) and the well-being one attains as an emotional and cognitive response. This study aimed to explore the role of illness impact perceptions in mediating the link between hope, social support and subjective well-being in parents of children with cancer.

Methods

The cross-sectional study included 108 parents of children aged 7–18 diagnosed with cancer at least 6 months prior to the study. The parents completed one questionnaire comprising five instruments: perceived impact of illness, hope, social support, positive and negative affect (the emotional component of well-being) and life satisfaction (the cognitive component of well-being). Descriptive statistics and Pearson correlations were conducted for all study variables. SEM analysis was performed to examine the study’s theoretical model.

Results

The current sample included 108 parents of children with cancer recruited from two pediatric hematology-oncology wards in two different hospitals in central Israel. Most participants were mothers (70.4%), and the mean age was 44.46. The main results indicated that hope and social support correlated negatively with perceptions of the illness’ impact. Illness impact perceptions mediated the relations between hope, social support and positive emotions, which means that when the parents perceived their child’s illness as less impactful on the family, they experienced higher levels of emotional well-being.

Conclusion

A parent with social support resources and higher levels of hope experiences higher levels of positive perceptions regarding their child’s illness. Higher levels of positive perceptions allow the parent to express more positive than negative emotions, thus maintaining a more optimal level of subjective emotional well-being. The findings offer implications for healthcare teams to enhance sensitivity to parents’ needs and to help parents attain more resources, positive perceptions, and well-being.
Sense of safety or meaning in danger? Real-contact stick fighting as an imagistic ritual
Authors: Pauha Teemu
Published: July 2024

It is a common assumption that human behavior is guided by a desire to feel safe and avoid harm. However, this view is challenged by the popularity of high-risk leisure sport and other practices that involve subjecting oneself to a considerable danger with no apparent gain. By using real-contact stick fighting as an example, I suggest that the attractiveness of at least some such practices can be explained by cognitive dynamics that are typical of affectively intense rituals such as initiations. Affectively intense rituals are known to enhance personal meaning-making and foster identity fusion, that is, the overlapping of personal and social identities. The sense of meaning thus engendered effectively satisfies common identity motives and thus elicits positive affect. By introducing ritual studies perspectives into the edgework paradigm that is commonly used to conceptualize voluntary risk taking, I contribute to an increased understanding of the cognitive processes motivating participation in extreme leisure sport.
Curative care expenditure of outpatient anxiety disorder in Liaoning Province, 2015-2020-based on “System of Health Accounts 2011”
Authors: Shi Xiaoxia , Zhao Yue , Wan Quan , Chai Peipei , Ma Yuedan
Published: July 2024

Introduction

Anxiety disorders are the most common mental disorder, experienced by more than a quarter of the population. This study examines total outpatient curative care expenditures (CCE) for anxiety disorders and changes in their composition based on the System of Health Accounts 2011 (SHA 2011).

Methods

This study used multi-stage stratified random from a total of 9,318,513 outpatient sample data by 920 healthcare organizations, a total of 109,703 cases of anxiety disorders from 53 sample organizations (5.76%) from 2015 to 2020. Univariate analysis, multifactor analysis and structural equation modeling (SEM) were used to explore the influential factors affecting outpatient CCE for anxiety disorders.

Results

Anxiety disorder outpatient CCE from 2015 to 2020 continued to increase from CNY 99.39million in 2015 to CNY 233.84 million in 2020, mainly concentrated in western medicine costs, 15–64 years, general hospital, generalized anxiety disorder and public financing. The results of univariate analysis showed statistically significant differences in all subgroups, and the results of multivariate analysis and SEM showed that the choice to purchase western drugs, purchase prepared Chinese drugs, choice to have a checkup, urban employees’ basic medical insurance, and 0–14 years old were associated with high anxiety disorder outpatient CCE.

Conclusion

Initiatives to improve the essential drug system, reduce the out-of-pocket (OOP) ratio, and strengthen primary health care to effectively reduce the medical burden on patients.
Keeping young researchers out of harm’s way: conducting youth participatory action research with young people experiencing homelessness
Authors: Ratliff G. Allen , Cosgrove Darren , Yang Jessica O. , Sarabia Richard , Harvey Taylor L. , Jeffcoat Nathan , Lightfoot Marguerita , Adams Sherilyn , Lund Ilsa , Auerswald Colette L.
Published: July 2024

Introduction

Youth Participatory Action Research (YPAR) is an approach to conducting research with youth populations in order to effectively engage youth in research that impacts their lives. Young people experiencing homelessness (YEH) are vulnerable to power and social environments in ways that call attention to their experiences in research.

Methods

The context for this paper was a qualitative YPAR project to incorporate youth voice into the operations of a larger research study that hired youth as researchers. Participant-researchers provided feedback and consultation with senior staff in order to improve their access to resources, safety, and stability.

Results

Themes that emerged from thematic analysis of reflections, discussions, and meetings showed the need for consistent access to food, the risk of environmental violence targeting youth researchers, the structural and experiential barriers to professional engagement, and the benefits that young researchers experienced as part of their work in the study.

Discussion

Recommendations and lessons learned are described, notably to ensure that youth are paid and provided food, to construct effective safety plans during fieldwork, and to provide a flexible, inclusive, trauma-responsive approach to supervision of project tasks.
Beyond sight: Comparing traditional virtual reality and immersive multi-sensory environments in stress reduction of university students
Authors: Baktash Hanieh , Kim Daejin , Shirazi Amin
Published: July 2024

Introduction

This study aims to assess the efficacy of traditional virtual reality (VR) and Immersive Multi-sensory Environments (IME) in mitigating anxiety levels among university students. The study can address the following research questions: 1) What disparities exist in anxiety levels before and after exposure to traditional VR and IME? 2) How do anxiety levels compare between participants exposed to IME and those in a VR environment?

Methods

The research adopted a twophase approach involving participants exhibiting moderate to high-stress levels. In the second phase, participants were randomly assigned to either a VR group (solely visual stimulation) or an IME group (comprising visual, auditory, and olfactory stimuli). The State-Trait Anxiety Inventory (STAI) were utilized to assess stress and anxiety levels before and after each experiment.

Results

The findings suggest that participants’ experiences in both VR and IME environments effectively contributed to reducing anxiety levels and fostering a tranquil atmosphere. Both experimental groups reported a significantly heightened sense of relaxation post-experiments. Although the disparity was not statistically significant, the IME group displayed a more pronounced reduction in stress levels compared to the VR group.

Discussion

The research underscores the significance of considering the built environment and sensory design in addressing mental health challenges among college students. Further exploration and integration of such approaches into educational settings could significantly contribute to establishing more supportive and conducive environments for student success.
Blackfeet innovation pathways to food sovereignty: sustainability through indigenous-led research partnerships
Authors: Paul Kimberly L. , Ruppel Kristin T. , Young Micaela M. , Caplins Laura , Ramaker Jill Falcon , Carter Christopher J. , Seeley William B. , Falcon Christen , Berger Andrew
Published: July 2024

The Blackfeet Nation in northwestern Montana, United States, is implementing its Agriculture Resource Management Plan (ARMP), an Indigenous-led, sustainable agriculture plan prioritizing economic development for Indigenous producers, intergenerational health and well-being of Amskapi Piikani Blackfeet people, and ecological and cultural sensitivities within this sovereign nation and its traditional territories. Since the passage of the American Indian Agricultural Resource Management Act of 1993, only three Tribes have drafted and finalized Agricultural Resource Management Plans (ARMPs). The Blackfeet ARMP is now being held up as a national model of Tribal sovereignty. “Blackfeet Innovation Pathways to Food Sovereignty,” an Indigenous-led research project, emerged from the Blackfeet Nation’s community-based strategic planning process identifying gaps, systemic barriers and impactful solutions for achieving Blackfeet food sovereignty through the implementation of the Blackfeet Nation ARMP, along with research influenced by the ARMP. This paper provides a community case study of the ongoing process and offers a translational model of sustainable agriculture and food sovereignty within Indigenous lands to improve the economic futures of producers and their families, as well as health outcomes for Native communities.
Socioeconomic Status and Adherence to Preventive Measures During the COVID-19 Pandemic in Switzerland: A Population Based Digital Cohort Analysis
Authors: Tancredi Stefano , van der Linden Bernadette W. A. , Chiolero Arnaud , Cullati Stéphane , Imboden Medea , Probst-Hensch Nicole , Keidel Dirk , Witzig Melissa , Dratva Julia , Michel Gisela , Harju Erika , Frank Irene , Lorthe Elsa , Baysson Hélène , Stringhini Silvia , Kahlert Christian R. , Bardoczi Julia B. , Haller Moa Lina , Chocano-Bedoya Patricia O. , Rodondi Nicolas , Amati Rebecca , Albanese Emiliano , Corna Laurie , Crivelli Luca , Kaufmann Marco , Frei Anja , von Wyl Viktor
Published: July 2024

Objectives

To assess the association between socioeconomic status (SES) and self-reported adherence to preventive measures in Switzerland during the COVID-19 pandemic.

Methods

4,299 participants from a digital cohort were followed between September 2020 and November 2021. Baseline equivalised disposable income and education were used as SES proxies. Adherence was assessed over time. We investigated the association between SES and adherence using multivariable mixed logistic regression, stratifying by age (below/above 65 years) and two periods (before/after June 2021, to account for changes in vaccine coverage and epidemiological situation).

Results

Adherence was high across all SES strata before June 2021. After, participants with higher equivalised disposable income were less likely to adhere to preventive measures compared to participants in the first (low) quartile [second (Adj.OR, 95% CI) (0.56, 0.37–0.85), third (0.38, 0.23–0.64), fourth (0.60, 0.36–0.98)]. We observed similar results for education.

Conclusion

No differences by SES were found during the period with high SARS-CoV-2 incidence rates and stringent measures. Following the broad availability of vaccines, lower incidence, and eased measures, differences by SES started to emerge. Our study highlights the need for contextual interpretation when assessing SES impact on adherence to preventive measures.
The Composition of the L5-S1 Neural Foramen on MRI—A Retrospective Cohort Study Examining the Anatomy Relevant to Transforaminal Epidural Steroid Injections
Authors: Stewart Zachary E. , Mercer Ronald W. , Staffa Steven , Simeone F. Joseph , Huang Ambrose J.
Published: July 2024

Transforaminal epidural steroid injections are commonly used for the treatment of radicular pain. Some providers opt for an antero-superior approach and others a postero-inferior approach. In this retrospective cohort study, we evaluated MRI evident anatomic differences between the antero-superior and postero-inferior neural foramen at L5-S1 that may be relevant when choosing an approach for injections. A total of 29 L5-S1 neural foramina that were targeted for transforaminal epidural steroid injections were included. Pre-procedure MRIs were assessed for the distribution of the fat within the foramen. Additionally, the presence of foraminal vessels and foraminal stenosis and the presence/absence of anterolisthesis was also observed. Final imaging data were obtained by majority opinion of three or four radiologists. There was a statistically significant difference in the distribution of foraminal fat between the postero-inferior foramen and the antero-superior foramen (p < 0.001), with more fat generally in the postero-inferior foramen. Foraminal vessels were not consistently visualized. There was weak inter-reader reliability for the presence of vessels. In conclusion, this study suggests that there is a difference in the distribution of foraminal epidural fat between the postero-inferior and antero-superior foramen at L5-S1. Through MRI, vessels are inconsistently visualized and cannot be reliably detected on conventional MRI between readers.
Network Goodness Calculus Propositions
Authors: Bershadsky Marina , Ivanković Božidar , Pušić Marko
Published: July 2024

We coin the term “network goodness” for a value we define for a network embedded in a given environment as a metric that describes the suitability of that network for meeting a demand. Three formulas are proposed to calculate the metric from three variable values. The first variable considers parts of the environment gravitated by the network. For these parts of the environment, we define a value that measures user costs refusing them the use of the network. Last but not least, the network maintenance costs are considered. The results are obtained after focusing on infrastructure and transport networks, but can be used for other types of networks as well.
Unsupervised Domain Adaptation for Constraining Star Formation Histories
Authors: Gilda Sankalp , de Mathelin Antoine , Bellstedt Sabine , Richard Guillaume
Published: July 2024

In astronomy, understanding the evolutionary trajectories of galaxies necessitates a robust analysis of their star formation histories (SFHs), a task complicated by our inability to observe these vast celestial entities throughout their billion-year lifespans. This study pioneers the application of the Kullback–Leibler Importance Estimation Procedure (KLIEP), an unsupervised domain adaptation technique, to address this challenge. By adeptly applying KLIEP, we harness the power of machine learning to innovatively predict SFHs, utilizing simulated galaxy models to forge a novel linkage between simulation and observation. This methodology signifies a substantial advancement beyond the traditional Bayesian approaches to Spectral Energy Distribution (SED) analysis, which are often undermined by the absence of empirical SFH benchmarks. Our empirical investigations reveal that KLIEP markedly enhances the precision and reliability of SFH inference, offering a significant leap forward compared to existing methodologies. The results underscore the potential of KLIEP in refining our comprehension of galactic evolution, paving the way for its application in analyzing actual astronomical observations. Accompanying this paper, we provide access to the supporting code and dataset on GitHub, encouraging further exploration and validation of the efficacy of the KLIEP in the field.
From Genesis to Old Age: Exploring the Immune System One Cell at a Time with Flow Cytometry
Authors: Larbi Anis
Published: July 2024

The immune system is a highly complex and tightly regulated system that plays a crucial role in protecting the body against external threats, such as pathogens, and internal abnormalities, like cancer cells. It undergoes development during fetal stages and continuously learns from each encounter with pathogens, allowing it to develop immunological memory and provide a wide range of immune protection. Over time, after numerous encounters and years of functioning, the immune system can begin to show signs of erosion, which is commonly named immunosenescence. In this review, we aim to explore how the immune system responds to initial encounters with antigens and how it handles persistent stimulations throughout a person’s lifetime. Our understanding of the immune system has greatly benefited from advanced technologies like flow cytometry. In this context, we will discuss the valuable contribution of flow cytometry in enhancing our knowledge of the immune system behavior in aging, with a specific focus on T-cells. Moreover, we will expand our discussion to the flow cytometry-based assessment of extracellular vesicles, a recently discovered communication channel in biology, and their implications for immune system functioning.
A Comparative Study on Cognitive Assessment in Cerebellar and Supratentorial Stroke
Authors: Liu Qi , Zhang Yumei
Published: July 2024

This study aims to understand the cognitive profiles of cerebellar infarction patients and compare them to those with supratentorial infarctions, particularly frontal infarctions. This current study also aims to find reliable assessment tools for detecting cognitive impairment in cerebellar infarction patients. A total of fifty cerebellar infarction patients, sixty supratentorial infarction patients, and thirty-nine healthy controls were recruited. The Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Addenbrooke’s Cognitive Examination III (ACE-III), and Cerebellar Cognitive Affective Syndrome scale (CCAS-s) were used to assess global cognitive function. An extensive neuropsychological assessment battery was also tested to evaluate the characteristics of each cognitive domain. To assess the features of cognitive function, a comprehensive neuropsychological evaluation tool was also utilized. The cerebral infarction patients demonstrated cognitive impairment comparable to those with frontal infarcts, notably characterized by disturbance in attention and executive function. However, the degree of cognitive impairment was comparatively milder in cerebellar infarction patients. Furthermore, the patients in the cerebellar group had worse scores in the ACE-III and CCAS-s compared to healthy controls. The two assessments also demonstrated a significant area under the curve values, indicating their effectiveness in distinguishing cognitive impairment in cerebellar infarctions. In conclusion, cognitive impairment in a cerebellar infarction resembles frontal lobe dysfunction but is generally mild. It can be accurately assessed using the ACE-III and CCAS-s scales.
Determinants of Creativity in Migrant versus Urban Children: A Case Study in China
Authors: Dai Yiqi , Chen Shunan , Mao Fengqian , Xu Junfang
Published: July 2024

Objective: This study examines the current status and variations in creativity between migrant and urban children, exploring the influencing factors affecting creativity. Methods: We selected children from local households in Hangzhou City and non-local migrant households as participants. Their basic demographic information and creative tendencies were assessed using the Children’s Basic Situation Questionnaire and Williams’ Creativity Tendency Measurement Scale, respectively. A multi-model regression analysis was conducted to analyze factors influencing creativity. Results: This study included 1047 children. Significant differences were observed between urban and migrant children regarding age, family type, number of siblings, parental education, parental presence at home, parental guidance in learning, experience of changing schools, having their own room, and academic performance. In addition, migrant children exhibited significantly lower creativity levels compared to urban children. The multi-model regression analysis showed that migrant status, a good parent–child relationship, having parents who often guide learning, having their own room, and excellent academic performance significantly influenced children’s creativity. Conclusions: Migrant children display lower levels of creativity than their urban counterparts, with notable differences across several factors.
Effects of Schroth 3D Exercise on Adolescent Idiopathic Scoliosis: A Systematic Review and Meta-Analysis
Authors: Chen Chenting , Xu Jialu , Li Haifeng
Published: July 2024

(1) Background: This meta-analysis aims to systematically assess the effect size of Schroth three-dimensional exercise training on adolescent idiopathic scoliosis, especially for Cobb angles, angles of trunk rotation, and quality of life. (2) Methods: Randomized controlled trials (RCTs) focused on the effect of Schroth exercise on patients with adolescent idiopathic scoliosis (AIS) were retrieved from six databases, including PubMed, Embase, Cochrane Library, Web of Science, CNKI, and Wanfang. All publications until July 2023 were searched. Two researchers screened and evaluated the literature. Review manager (RevMan 5.3) statistical software was used for meta-analyses, and subgroup analysis and sensitivity analysis of the literature with high heterogeneity were further conducted. (3) Results: In total, 14 studies were included, including 538 adolescent idiopathic scoliosis patients. Compared with conventional physical therapy, Schroth 3D exercise training is more effective at reducing the Cobb angle (WMD = −3.32, 95%CI [−4.15, −2.50], p < 0.001) and improving the trunk rotation angle (WMD = −2.24, 95%CI [−3.00, −1.48], p < 0.001), quality of life (SMD = 2.80, 95%CI [1.53, 4.06], p < 0.001), and WRVAS (WMD = −2.92, 95%CI [−3.25, −2.60], p < 0.001), as well as enhancing the strength of the lumbar extensor (SMD = 1.79, 95%CI [1.46, 2.12], p < 0.001). (4) Conclusion: Compared with traditional therapy, Schroth 3D exercises are more effective at decreasing the Cobb angle and ATR in adolescent idiopathic scoliosis, improving patients’ quality of life, as well as enhancing the strength of the lumbar extensor.
Study on Antibacterial Durability of Waterproof Coatings with Different Base Materials
Authors: Gao Yuxuan , Chang Xuning , Shi Yuntong
Published: July 2024

Microbial corrosion of waterproof coatings causes structural damage to buildings and renovation materials and severely threatens human health. In practical applications, coatings with different base materials show different durabilities to external environmental influences. There is little literature on the antimicrobial durability performance of waterproof coatings. Therefore, this paper selected four standard waterproofing coatings, including polyurethane coatings, cement-based coatings, asphalt-modified polymer coatings, and polymer emulsion coatings, as the main body of this study. Their antimicrobial abilities against Gram-negative Escherichia coli, Gram-positive Staphylococcus aureus, Candida albicans, and mold were tested after experiencing three kinds of harsh environments: Ultraviolet ray (UV), water immersion, and low temperature. The results show that the extreme climates significantly reduced the ability of the four coatings to resist mold, and the highest growth rate of bacteria was 54.64%. Under UV conditions, the polymer emulsion coatings were significantly more resistant to Candida albicans, and the optical density of the bacterial liquid showed a negative growth trend. The microstructural integrity of the polymer emulsion coatings was found to be damaged by Scanning Electron Microscope (SEM) observation. This work improves the durability application research on these coatings and provides a valuable reference for developing new environmentally friendly, antibacterial, and anticorrosive waterproof coatings.
Risk Factors for Emergency Room Visits in Patients with Digestive Bleeding Associated with Direct-Acting Anticoagulants
Authors: Ruiz-Ramos Jesús , Pérez-Méndez María Carmenza , Socias-Cañellas Catalina Maria , Lozano-Polo Laura , Plaza-Diaz Adrián , Puig-Campmany Mireia , Juanes-Borrego Ana María
Published: July 2024

Gastrointestinal bleeding is the main cause of admission to the emergency services of patients taking direct-acting oral anticoagulants (DOACs). Little is known about the effects of treatment modification on the risk of readmission, especially in elderly patients. This retrospective observational study included elderly patients with atrial fibrillation who were on DOACs and who were admitted to the emergency department due to gastrointestinal bleeding from 2018 to 2023. To evaluate the risk factors for readmission 90 days after discharge, a multivariate analysis was conducted, which included patient comorbidities, concomitant treatment, changes in anticoagulant treatment, and the prescription of DOACs at discharge. One hundred and thirty-nine patients were included. At discharge, anticoagulant therapy was modified in 44 (31.6%) patients, 16 (36.3%) patients were switched from one DOAC to another, 23 (52.2%) to heparins, and 5 (11.3%) to vitamin K antagonists. A total of 21 (15.1%) patients returned to the emergency department within 90 days after discharge due to new bleeding events. No significant differences were observed depending on the modification of treatment at discharge. The presence of cognitive impairment was the only factor associated with readmission at 90 days. Patients who undergo treatment with DOACs and have gastrointestinal bleeding at discharge are at risk of readmission to the emergency room due to new bleeding events. No benefit was observed in modifying anticoagulant treatment at discharge.
Review of Switched Reluctance Motor Converters and Torque Ripple Minimisation Techniques for Electric Vehicle Applications
Authors: Abdel-Aziz Ali , Elgenedy Mohamed , Williams Barry
Published: July 2024

This paper presents a review of the most common power converters and torque ripple minimisation approaches for switched reluctance motors (SRMs). Unlike conventional three-phase AC motors, namely squirrel cage induction motors and permanent magnet synchronous motors, which require a typical three-phase inverter for operation, the switched reluctance motor requires a different topology power converter for reliable and efficient operation. In addition, due to the non-linear, discrete nature of SRM torque production, torque ripple is severely pronounced, which is undesirable in servo applications like electric vehicles. Hence, deploying a proper torque control function for smooth and quiet motor operation is crucial. This paper sheds light over the most popular SRM power converters as well as torque ripple minimisation methods, and it suggests an optimal SRM drive topology for EV applications.
Recent Progress in Heat and Mass Transfer Modeling for Chemical Vapor Deposition Processes
Authors: Łach Łukasz , Svyetlichnyy Dmytro
Published: July 2024

Chemical vapor deposition (CVD) is a vital process for deposit of thin films of various materials with precise control over the thickness, composition, and properties. Understanding the mechanisms of heat and mass transfer during CVD is essential for optimizing process parameters and ensuring high-quality film deposition. This review provides an overview of recent advancements in heat and mass transfer modeling for chemical vapor deposition processes. It explores innovative modeling techniques, recent research findings, emerging applications, and challenges in the field. Additionally, it discusses future directions and potential areas for further advancement in CVD modeling.
Influence of Wind Turbines as Dominants in the Landscape on the Acceptance of the Development of Renewable Energy Sources in Poland
Authors: Świdyńska Natalia , Witkowska-Dąbrowska Mirosława , Jakubowska Dominika
Published: July 2024

Where there are wind turbines, they become a dominant feature of the landscape. The landscape is one of the frequently identified types of impacts of these investments on the natural environment and people. Specially prepared methodologies are used to assess the impact of turbines on the landscape. No less important is the subjective feeling of residents because it can affect the social acceptance of these investments. The work answers questions about residents’ opinions on the impact of energy installations on the landscape. The results of the study, using chi-square, indicate that there is a relationship between the presence of windmills in the municipality and support for their development, as well as the evaluation of both the positive as well as the negative. Residents of a municipality where wind turbines have been around for more than a dozen years considered the introduction of a very strong visual stimulus as the most important negative impact on the landscape. Residents of a municipality without wind power considered interference with ecosystems as the most important negative impact.
The Emergence of Neuroleadership in the Knowledge Economy
Authors: Bratianu Constantin , Staneiu Roxana-Maria
Published: July 2024

“The Emergence of Neuroleadership in the Knowledge Economy” explores the field of neuroleadership in today’s constantly changing economy, highlighting the transition from traditional leadership to neuroleadership. Neuroleadership renders itself as a novel approach to the leadership theory, which brings together insights from neuroscience, psychology, and leadership studies. It emphasizes understanding the workings of the brain and human behavior in order to drive leadership effectiveness, at individual, team, and organizational levels. Additionally, the knowledge economy is characterized by the significant role of knowledge and intellectual capital when it comes to driving economic growth and organizational development. It highlights the creation, dissemination, and sharing of knowledge as important pillars for productivity and competitive advantage, shaping industries and transforming leadership traditional models. Through an extensive literature review and by employing the Dulewicz and Higgs leadership model, the authors showcase what are the intellectual, managerial, and emotional competencies that make neuroleadership the next natural step in leading teams and organizations. This article proposes a comparative matrix between traditional leaders and neuroleaders, and highlights a novel framework for better understanding neuroleadership.
Androgenic Steroid Hormones and Endurance Exercise in Athletic Women
Authors: Hackney Anthony C. , Prado Raul Cosme Ramos , Dolan Eimear
Published: July 2024

This study investigated the impact of intensive endurance exercise on circulating androgenic steroid hormones in women. Fifteen normally menstruating athletic women participated. They completed intensive endurance exercise (treadmill running) until volitional fatigue in their follicular phase, with blood samples collected at pre-exercise, volitional fatigue, 90 min and 24 h into recovery. The steroid hormones (total, free testosterone, dehydroepiandrosterone [DHEA], and DHEA-sulfate [DHEA-S], cortisol) were analyzed in blood sera. Non-parametric statistics were used to assess changes across exercise and recovery. At volitional fatigue, all hormones, except free testosterone, were significantly (p < 0.05) increased compared to pre-exercise levels. Most hormones remained elevated through 90 min of recovery, with DHEA, DHEA-S, and total testosterone changes being significant (p < 0.05). At 24 h of recovery, hormonal levels were reduced; specifically, DHEA, DHEA-S, and total testosterone compared to baseline (p < 0.01 to 0.06). Increases in cortisol levels at volitional fatigue and 90 min of recovery were correlated with reductions in total testosterone, DHEA, and DHEA-S observed at 24 h of recovery (rho > −0.62, p < 0.05). In conclusion, in menstruating women performing intensive endurance exercise during their follicular phase, their androgenic steroid hormones remain elevated during early recovery but are suppressed at 24 h of recovery. The latter finding indicates that establishing a resting endocrine equilibrium requires a longer recovery period than 24 h.
Complete Chloroplast Genome Sequences of Endangered Tropical Fosbergia Species (Family: Rubiaceae)
Authors: Chen Lilin , Zhu Wen , Song Yu , Zhou Qihai , Li Huimin
Published: July 2024

Fosbergia shweliensis (Anth.) Tirveng. & Sastre, Fosbergia petelotii Merr. ex Tirveng. & Sastre, and Fosbergia thailandica Tirveng. & Sastre are reported as in extremely small populations in China. The three tree species all belong to the Forbergia of Rubiaceae, and little is known about the structural and evolutionary features of Fosbergia chloroplast genomes. In this study, four chloroplast genomes from three Fosbergia species were assembled, subjected to comparative genomics, and phylogenetically analyzed. The complete chloroplast genomes of Fosbergia showed highly conserved structures and were 154,623–154,730 bp in size, with a GC content of 37.6%. A total of 130 genes were annotated, comprising 85 protein-coding genes, 37 tRNA genes, and 8 rRNA genes. There are 119–128 long repeats and 39–42 SSRs in four chloroplast genomes. Highly variable loci trnS-trnG and psaA-ycf3 were detected as candidate markers for species identification in Fosbergia. Using 31 complete chloroplast genomes, the phylogenetic relationships among three Fosbergia species were investigated by constructing phylogenetic trees. Fosbergia and Gardenia are sister clades, and F. petelotii is more closely related to F. shweliensis than to F. thailandica. This study provided more molecular data to illuminate the genus Fosbergia evoltution in Rubiaceae.
A New Species of Hydrozoan Jellyfish Eutima onahamaensis and New Record of Eutima diademata (Hydrozoa, Leptothecata) from Japan
Authors: Toshino Sho , Ishii Rintaro , Mizutani Seiichi
Published: July 2024

The family Eirenidae is one of the major taxa of the order Leptothecata, comprising approximately 80 species from ten genera. In this study, taxonomic investigations, including morphological observations and molecular 16S phylogenetic analyses, were conducted on unknown Eirenidae specimens collected off the coast of Iwaki, Fukushima Prefecture, eastern Japan, in June 2022. The specimens had the following morphological characteristics: marginal warts and tentacular bulbs with lateral cirri and without adaxial papillae, a mouth with simple lips, four simple radial canals, and eight statocysts common to the genus Eutima. However, this species can be distinguished from other species of Eutima by the number of tentacles, number and shape of marginal warts, position of the gonads, and gastric peduncle length. Moreover, the monophyly of the species was evident in the 16S rRNA phylogenetic tree (as indicated by the high bootstrap value of 100%), thereby supporting the validity of the new species. Based on these results, we describe it as a new species, Eutima onahamaensis, for taxonomic stabilization. We also made detailed observations of the morphology and molecular phylogenetic analyses of one of the species newly recorded in Japan: Eutima diademata. A comparative table of the primary diagnostic characteristics of Eutima has been provided. This study provided taxonomic keys for identifying species in the genus Eutima.