bluuebunny/crossref_metadata_2025 huggingface dataset:
A mixed-methods study of VA video connect utilization among veterans with diabetes experiencing housing instability during the pandemic
Authors: Kinney Rebecca L , Copeland Laurel A , Tsai Jack , Abbott Alice A , Wallace Kate , Walker Lorrie A , Weber Jillian , Katsos Shara , McInnes Donald K
Published: October 2024

Introduction

Prior to the coronavirus disease-2019 (COVID-19) pandemic the U.S. Department of Veterans Affairs (VA) had the largest telehealth program in the United States. The pandemic motivated providers within the VA to expand telehealth in effort to reduce disrupted care while mitigating risks. The pandemic provides a rare opportunity to examine how to better engage veterans experiencing housing instability (HI) in telehealth diabetes care.

Methods

Mixed methods design to examine VA video connect (VVC) diabetes care utilization among veterans experiencing HI from March 1, 2019, to March 1, 2022, combining multivariable regression analyses of VA administrative data with semi-structured interviews. Study aims included: (a) examine changes in diabetes care delivery mode over the peri-pandemic timeframe; (b) identify sociodemographic and clinical characteristics associated with VVC care among veterans with HI; and (c) understand the facilitators and barriers of VVC utilization.

Results

Totally, 5904 veterans were eligible for study analysis. Veterans who are female (OR: 1.63; 95% CI: 1.3, 2.0; p < 0.0001), self-identify as Hispanic (OR: 1.44; 95% CI: 1.1, 1.9; p = 0.02), are married (OR: 1.39; 95% CI: 1.2, 1.6; p < 0.0001), and are in VA priority group 1 (OR: 1.21; 95% CI 1.1, 1.4; p = 0.004) were more likely to use VVC the pandemic. Veterans of older age (OR: 0.97; 95% CI: 0.97, 0.98; p < .0001) and rural dwelling (OR: 0.85; 95% CI: 0.7, 1.2; p = 0.04), were less likely to use VVC. Thirteen VA providers and 15 veterans were interviewed. Veterans reported that decisions about using VVC were driven by limitations in in-person care availability, safety, and convenience.

Discussion

Telehealth played an important role in providing veterans with HI access to diabetes care during the pandemic. Future interventions should seek to increase education and technology in effort to increase VVC uptake into routine diabetes care to ensure veterans’ optimal and equitable access.
Assessing the performance of large language models (LLMs) in answering medical questions regarding breast cancer in the Chinese context
Authors: Piao Ying , Chen Hongtao , Wu Shihai , Li Xianming , Li Zihuang , Yang Dong
Published: October 2024

Purpose

Large language models (LLMs) are deep learning models designed to comprehend and generate meaningful responses, which have gained public attention in recent years. The purpose of this study is to evaluate and compare the performance of LLMs in answering questions regarding breast cancer in the Chinese context.

Material and Methods

ChatGPT, ERNIE Bot, and ChatGLM were chosen to answer 60 questions related to breast cancer posed by two oncologists. Responses were scored as comprehensive, correct but inadequate, mixed with correct and incorrect data, completely incorrect, or unanswered. The accuracy, length, and readability among answers from different models were evaluated using statistical software.

Results

ChatGPT answered 60 questions, with 40 (66.7%) comprehensive answers and six (10.0%) correct but inadequate answers. ERNIE Bot answered 60 questions, with 34 (56.7%) comprehensive answers and seven (11.7%) correct but inadequate answers. ChatGLM generated 60 answers, with 35 (58.3%) comprehensive answers and six (10.0%) correct but inadequate answers. The differences for chosen accuracy metrics among the three LLMs did not reach statistical significance, but only ChatGPT demonstrated a sense of human compassion. The accuracy of the three models in answering questions regarding breast cancer treatment was the lowest, with an average of 44.4%. ERNIE Bot's responses were significantly shorter compared to ChatGPT and ChatGLM ( p < .001 for both). The readability scores of the three models showed no statistical significance.

Conclusions

In the Chinese context, the capabilities of ChatGPT, ERNIE Bot, and ChatGLM are similar in answering breast cancer-related questions at present. These three LLMs may serve as adjunct informational tools for breast cancer patients in the Chinese context, offering guidance for general inquiries. However, for highly specialized issues, particularly in the realm of breast cancer treatment, LLMs cannot deliver reliable performance. It is necessary to utilize them under the supervision of healthcare professionals.
Acceptability of the power over pain portal among patients awaiting tertiary care consultation: A qualitative study of patients’ perceptions
Authors: King Alesha C , Zahrai Amin , Bisson Etienne , Shergill Yaadwinder , Andreev Pavel , Bosma Rachael , MacNeil Alexandra O , Radhakrishnan Arun , Rash Joshua A , Wilson Rosemary , Poulin Patricia
Published: October 2024

Objective

Chronic pain affects approximately 7.6 million Canadians and access to care remains an issue. The Power Over Pain (POP) Portal offers immediate access to evidence-based resources ranging from low- (e.g. education, self-management), to high- (e.g. individual counseling) intensity. We explored the POP Portal's acceptability, usability, and perceived usefulness among patients newly referred to a tertiary care pain clinic.

Methods

We used a descriptive, qualitative approach with a prospective cohort of 60 adult patients recently referred to The Ottawa Hospital Pain Clinic. Patients were offered an orientation session and asked to participate in a seven-week follow-up interview. Data were thematically analyzed in an iterative process, whereby responses were reviewed and coded by two members of the research team.

Results

Of the 60 patients referred to the POP Portal by clinic clerks, 45 participated in the orientation session, and 40 completed a four-week follow-up. All 40 patients had used the POP Portal and recommended that we continue to offer the POP Portal to patients awaiting care. We identified overarching themes of acceptability (five subthemes), usability (ten subthemes), accessibility (three subthemes), and patient value of the POP Portal (three subthemes). This includes (1) the POP Portal provides easy access to chronic pain resources; (2) the POP Portal is helpful in developing an understanding of chronic pain; and (3) improvements to the POP Portal are needed to increase usability and foster a user-friendly experience.

Conclusions

The POP Portal offers accessible and diverse resources for people living with pain awaiting a tertiary care consultation; however, patients would like to see resources specific to diagnosis. Improvements are suggested to allow greater increase the POP Portal usability.
Sonic Bouquet: Decoding Cross-Modal Correspondences Between Timbre and Scent
Authors: Zacharakis Asterios
Published: October 2024

The examination of cross-modal correspondences between auditory and olfactory senses opens up an intriguing perspective into the study of extra-musical meaning. In a behavioral experiment, musically trained participants were presented with 26 complex synthetic tones and 12 aromatic stimuli. Their task was to report potential associations between the two. The data analysis revealed that the majority of scents featured at least one association with a sound that was above chance. The salient acoustical correlates of basic aromatic categories could be summarized as follows: both fruity (e.g., cherry, melon, and pomegranate) and sour aromas exhibited a positive correlation with pitch. Fruity scents, in addition, were more likely to be associated with sounds featuring pronounced low harmonic partials (1st–4th), low noise content, low roughness, and a greater number of distinct pitches. Conversely, sour aromas were linked with stronger energy in the higher frequencies. Sweet scents correlated with sounds characterized by a lower spectral centroid, whereas aromas in the spicy/other category were associated with weak lower partials (fundamental frequency in particular) and stronger noisy components.
Patient and Community Health Worker (CHW) Perspectives on a CHW-delivered Nutrition Intervention for Low-Income Adults with Hypertension: A Qualitative Study
Authors: Gu Kristine D. , Cheng Jessica , Malone Ashlie , Faulkner Katherine C. , Bejarano Oldy , Gelsomin Emily , Thorndike Anne N.
Published: October 2024

Introduction/Objectives:

Adults with food insecurity (FI) face barriers to hypertension management, including difficulty adhering to diet recommendations. Few community health worker (CHW) interventions focus on diet to improve blood pressure. This qualitative study elicited patient and CHW perspectives on healthy eating and a future CHW nutrition intervention for patients with hypertension.

Methods:

Twenty-five patients with hypertension and FI and 5 CHWs participating in a hypertension health coaching program from 5 Boston-area health centers participated in semi-structured interviews from July to September 2023. Interviews were audio recorded, transcribed, and analyzed using the Framework Method.

Results:

Themes included: 1) Variable patient knowledge about dietary patterns for hypertension management and low confidence in interpreting nutrition labels; 2) Culture influenced healthy food perception; and 3) Barriers to healthy eating included cost, limited cooking abilities/supplies, and competing demands. Patients and CHWs favored simple nutrition education materials (e.g., traffic light nutrition ranking, healthy meals on a budget). Patients had mixed opinions about CHW-accompanied supermarket visits.

Conclusions:

This study identified culture, knowledge gaps, and budget constraints as factors influencing diet among patients with hypertension and FI. A CHW-delivered intervention could include simplified nutrition education, strategies for healthy eating on a budget, and linkage to community-based food programs.
Secondary Displacement was Common in Healing Distal Femur Fractures in a Cohort of Elderly Patients
Authors: Paulsson Martin , Ekholm Carl , Rolfson Ola , Tranberg Roy , Geijer Mats
Published: October 2024

Introduction

Surgical treatment of distal femoral fractures (DFFs) in osteoporotic bone is challenging despite improvements in hardware and surgical techniques. The occurrence and degree of secondary displacement during healing after bridging plate fixation are still unknown. This study aimed to assess the occurrence and degree of secondary displacement in healing DFFs in elderly patients and correlate the secondary displacement to body mass index, bone density, and weight-bearing regimen.

Patients and Methods

The study involved 32 patients, 65 years or older, with a DFF of AO/OTA types 33 A2-3, B1-2, C1-2, and 32(c) A-C,1-3, including peri-prosthetic fractures with stable implants. Twenty-seven patients had at least 8 weeks of follow-up, and 21 patients had a complete 1-year follow-up. Minimally invasive surgery was performed using a distal anatomical femoral plate as a long bridge-plating construct. Secondary displacement was assessed with computed tomography of the entire femur postoperatively and at 8, 16, and 52 weeks. Femoral length, coronal angulation (varus/valgus), and subsidence as the change in distance between the distal joint surface and a specified locking screw were measured.

Results

There was a statistically significant mean femoral shortening at 52 weeks of 4.7 mm (SD 3.9, (95% CI 2.9–6.5), P < 0.001) mainly by subsidence of the distal fragment. Most patients experienced limited coronal angulation. There was no correlation between body mass index or bone density and secondary displacement. At the 1-year follow-up, no patient needed revision surgery for non-union or plate breakage. Restricted weight-bearing for 8 weeks did not prevent secondary displacements or adverse events such as cut-outs.

Conclusion

Modern dynamic plate osteosynthesis could not prevent commonly occurring fracture subsidence in DFF in an elderly cohort. Restricted weight-bearing for 8 weeks did not prevent secondary displacements or mechanical adverse events.
Electroless silver plating on fabrics for antimicrobial coating: comparison between cotton and polyester
Authors: Ferrari Ivan Vito , Castellino Micaela , Pisani Anissa , Giuntoli Giulia , Cavallo Aida , Al Kayal Tamer , Mazzetti Paola , Rosellini Alfredo , Sidoti Maria , Cataldo Antonino , Pistello Mauro , Soldani Giorgio , Losi Paola
Published: October 2024

In the past few years, due to the Covid-19 pandemic, the interest towards textiles with antimicrobial functionalities faced a significant boost. This study proposes a rapid and convenient method, in terms of reactants and equipment, for fabricating antimicrobial coatings on textiles. Through the electroless silver plating reaction, silver coatings were successfully applied on cotton and polyester, rapidly and at room temperature. Functionalized samples were characterized by morphological (optical and scanning electron microscopies) and chemical tests (X-ray photoelectron spectroscopy, XPS) to investigate the nature of the silver coating. Although distinct nanoparticles did not form, XPS analysis detected the presence of silver, which resulted in an increased surface roughness and hydrophobicity of both cotton and polyester textiles. Ag-coated samples exhibited approximately 80% biocompatibility with murine L929 fibroblasts or human HaCaT cells, and strong antibacterial properties against Escherichia coli in direct contact tests. In antiviral experiments with SARS-CoV-2 virus, treated cotton showed a 100% viral reduction in 30 min, while polyester achieved 100% reduction in 1 h. With a human norovirus surrogate, the Feline Calicivirus, both treated textiles have a faster antiviral response, with more than 60% viral reduction after 5 min, while achieving a 100% reduction in 1 h. In conclusion, this study presents a fast, efficient, and low-cost solution for producing antimicrobial textiles with broad applications in medical and healthcare scenarios.
Trends in Anterior Cruciate Ligament Reconstruction Techniques and Postoperative Care Among Leaders in the Field: A Survey of the Herodicus Society
Authors: Engler Ian D. , Fox Michael A. , Curley Andrew J. , Mohr Damaris S. , Dadoo Sahil , Arner Justin W. , Musahl Volker , Bradley James P.
Published: October 2024

Background:

Despite a growing body of literature regarding anterior cruciate ligament reconstruction (ACLR), there remains a wide diversity in surgical technique and clinical practice across providers.

Purpose:

To (1) describe current ACLR practice preferences among members of the Herodicus society and (2) determine whether these preferences are influenced by years in practice and overall surgical volume.

Study Design:

Cross-sectional study.

Methods:

A 24-question survey investigating surgeons’ practices and preferred ACLR surgical techniques was sent via email to all active Herodicus Society members. Survey responses were subdivided by years of experience and overall ACLR annual case volume. Descriptive statistics were compiled and chi-square testing was utilized to determine the significance of experience and case volume on survey responses.

Results:

Of the 113 invited Herodicus Society members who perform ACLR, 69 (61%) completed the survey. Respondents had a mean ± SD of 30.9 ± 9.8 years of experience in clinical practice and performed a mean of 96.0 ± 50.7 primary and 21.6 ± 16.9 revision ACLR annually. Of revision cases, 72.1% were performed using a single-stage technique. Mean frequency of graft usage by surgeon was bone–patellar tendon–bone autograft (58.6%), quadriceps autograft (14.6%), hamstring tendon autograft (14.0%), and allograft (11.8%). The plurality of surgeons responded that they used anterolateral augmentation “rarely” in primary ACLR (39.1%) and “sometimes” in revision ACLR (31.9%), with the majority performing lateral extra-articular tenodesis (66.7%) rather than anterolateral ligament reconstruction (14.5%). Most surgeons would not allow a 20-year-old football player to return before 7 months after ACLR (71.0%) but highly valued return-to-sports testing to determine readiness (94.2%). Higher volume surgeons performed single-stage revision ACLR at a significantly higher rate (79.8% vs 62.9%, P = .02) and significantly differed in return-to-sports criteria, with a greater proportion relying primarily on biometric testing ( P = .01).

Conclusion:

The survey demonstrated that, in the Herodicus Society, a wide range of preferences exist regarding ACLR surgical technique. Bone–patellar tendon–bone autograft is the most frequent primary ACLR graft choice. Most participants have not embraced newer techniques such as anterolateral or suture tape augmentation. Return to sports is generally not allowed before 7 months and heavily factors-in return-to-sports testing metrics, suggesting that purely time-based criteria for return to sports is not modern practice among elite sports medicine surgeons.
Exploring Lived Experiences of Vulnerability in Nursing Management during the Coronavirus Disease 2019 Pandemic: A Phenomenological Study of Nurse Managers and Nurses
Authors: Heydarikhayat Nastaran , Ghanbarzehi Nezar , Darban Fatemeh , Kashani Zahra Atarodi , Rohani Camelia
Published: October 2024

Introduction

The Coronavirus Disease 2019 (COVID-19) pandemic placed enormous pressure on healthcare systems around the world, but it also provided valuable insights for healthcare organizations during this challenging period.

Objective

This study aimed to explore nurses’ lived experiences of vulnerability in hospital nursing management during the COVID-19 pandemic, and reflect on the lessons learned.

Methods

In this phenomenological study, 14 participants, including nurse managers at different levels and staff nurses, were selected by purposive sampling from one center university hospital. Data collection was done through in-depth individual semistructured interviews with participants and a review of weekly reports of crisis management meetings at the university hospital. Interviews were analyzed using Colaizzi's method in seven phases by MAXQDA software Version 10.

Results

One overarching theme, four themes, and 15 subthemes were obtained from analyses of interviews. Four themes of “nurses’ attrition,” “distrust of society to the organization,” “fragility in the organization's performance,” and “intensified inequalities” were extracted as threats to nursing management at the hospital. Subsequently, the weekly reports of crisis management meetings at the university hospital were analyzed to extract the solutions and lessons.

Conclusion

The unpreparedness of the healthcare system against a crisis can led to the loss of organizational assets, including medical staff and the credibility of the healthcare system. Limitations of the infrastructure at hospital became more obvious during the pandemic and caused serious threats to the healthcare system. Despite severe challenges along with the pandemic, it offered four valuable lessons in nursing management.
The Pact: How a Seemingly Race-Neutral Behavioral Policy Reproduced Racial Inequality at a Predominantly White Liberal Arts College
Authors: Gillis Alanna , van Stee Elena G.
Published: October 2024

How do seemingly nonracial organizational processes reproduce racial inequality? This study examines how “the Pact,” an ostensibly race-neutral COVID-19 behavioral policy implemented at a predominantly White U.S. liberal arts college, undermined social connection and belonging among students of color. Analyzing three waves of interviews with 30 undergraduates (N = 75 interviews), we document disparities in four domains of campus life: (1) social isolation in residence halls, (2) access to “safe” forms of rule breaking, (3) visibility and surveillance, and (4) stakes of violation. We identify three underlying mechanisms—unequal resource allocation, uneven rule enforcement, and color-blind decision-making—and demonstrate how distinct institutional conditions facilitated these processes. This analysis advances theoretical understandings of racialized organizational processes in higher education by connecting previously theorized mechanisms to specific university characteristics and practices.
“I Just Had to Do What I Had to Do”: Characterizing Direct and Indirect Prostate Cancer Treatment Costs for Black Survivors and Their Caregivers
Authors: Rice Hannah E. , L’Hotta Allison J. , Siječić Amela , Drake Bettina F. , Chang Su-Hsin , Kim Eric H. , Wright-Jones Robin , Shahid Mellve , Neal Camille , Housten Ashley J.
Published: October 2024

Introduction. Financial hardship is prevalent among Black prostate cancer survivors and exacerbates health disparities. Characterizing and sharing cost information with patients can facilitate well-informed treatment decision making. Our research explored the direct and indirect costs associated with prostate cancer treatment among Black men and their caregivers. Direct costs included out-of-pocket and insurance-related fees, and indirect costs included the unforeseen costs of care, including patient time, caregiver time, lost wages, and transportation. Methods. We conducted semi-structured interviews with Black prostate cancer survivors and their caregivers to learn about the experience of direct and indirect costs. The interview guide and data analysis were informed by the Measures of Financial Wellbeing framework to gain a better understanding of the material, behavioral, and psychosocial aspects of care-related costs. Guided by a qualitative descriptive approach, we used inductive and deductive coding for our thematic analysis. Results. Eleven prostate cancer survivors with a median age of 68 y (interquartile range [IQR] 62.0–71.5 y) and 11 caregivers with a median age of 64 y (IQR 58.5–70.5 y) participated. We grouped themes into 3 domains and their intersections (i.e., material, behavioral, psychosocial). Participants reported their work and insurance had a significant influence on their finances, treatment costs required rearranging of household budgets, and the weight of indirect costs varied. Ultimately, participants emphasized the significant impact of care costs and the adjustments needed to adapt to them. Discussion. The complexities of material, behavioral, and psychosocial domains of direct and indirect costs of prostate cancer are critical to address when supporting those diagnosed with prostate cancer when making preference-sensitive treatment decisions. The interconnectedness between indirect costs highlights the wide-ranging impact financial well-being has on prostate cancer survivors and caregivers.

Highlights

Direct and indirect costs have a wide-ranging impact on the material, behavioral, and psychosocial aspects of financial well-being of Black prostate cancer survivors and their caregivers. These results emphasize the need for sharing cost information to support medical decision making. Future research should focus on the design of cost-sharing interventions that target the complexities of direct and indirect costs collectively, rather than separately.
Large ischemic core defined by visually assessed ASPECTS predicts functional outcomes comparably accurate to automated CT perfusion in the 6–24 h window
Authors: Dittrich Tolga D , Nguyen Anh , Sporns Peter B , Toebak Anna M , Kriemler Lilian F , Rudin Salome , Zietz Annaelle , Wagner Benjamin , Barinka Filip , Hänsel Martin , Gensicke Henrik , Sutter Raoul , Nickel Christian H , Katan Mira , Peters Nils , Michels Lars , Kulcsár Zsolt , Karwacki Grzegorz M , Pileggi Marco , Cereda Carlo , Wegener Susanne , Bonati Leo H , Psychogios Marios , De Marchis Gian Marco
Published: October 2024

Introduction:

Automated CT perfusion (aCTP) is commonly used to select patients with anterior circulation large vessel occlusion (aLVO) for endovascular treatment (EVT). The equivalence of visually assessed Non-contrast CT Alberta Stroke Program Early CT Scores (ASPECTS) and aCTP based selection in predicting favorable functional outcomes remains uncertain.

Patients and methods:

Retrospective multicenter study of adult aLVO patients from the Swiss Stroke Registry (2014–2021) treated with EVT or best medical treatment 6–24 h after stroke onset. We assessed ASPECTS on non-contrast CT visually and ischemic core volumes on aCTP, defining ASPECTS 0–5 and aCTP CBF < 30% volumes ⩾50 mL as large ischemic cores. We used logistic regression to explore the association between CT modalities and favorable functional outcomes (modified Rankin Scale [mRS] score shift toward lower categories) at 3 months. Receiver operating characteristic (ROC) curve analysis compared the predictive accuracy of visually assessed ASPECTS and aCTP ischemic core for favorable outcomes (mRS 0–2) at 3 months.

Results:

Of 210 patients, 11.4% had ASPECTS 0–5, and 12.9% aCTP core volumes ⩾50 mL. Within the same model, ASPECTS but not aCTP core volumes were associated with favorable outcomes (ASPECTS: acOR 1.85, 95%CI 1.27–2.70, p = 0.001). The ROC curve analyses showed comparable diagnostic accuracy in predicting favorable functional outcomes (mRS 0–2) at 3 months (ROC areas: ASPECTS 0.80 [95%CI 0.74–0.86] vs aCTP core 0.79 [95%CI 0.72–0.85]).

Discussion and conclusion:

In patients with aLVO, visually assessed ASPECTS showed at least comparable accuracy to automatically generated CTP core volumes in predicting functional outcomes at 3 months.
The Role of Genetic Variations in the FAAH rs324420 Polymorphism and its Interaction with CRHR1 rs110402 and CNR1 rs2180619 in Anxiety and- Trauma Related Symptoms After Military Deployment
Authors: Leen Nadia , de Weijer Antoin , Boks Marco , Baas Johanna , Vermetten Eric , Geuze Elbert
Published: October 2024

Background

During military deployment, stress regulation is vital to protect against the development of anxiety and trauma-related symptoms. Brain endocannabinoids play an important role in stress regulation and previous research has shown that genetic variations in the FAAH rs324420 polymorphism demonstrate protective effects during stress. In addition, this polymorphism shows interactions with the CRHR1 and CNR1 polymorphisms on anxiety. The present study examines whether genetic variations of the FAAH, CRHR1 and CNR1 polymorphisms interact with the development of anxiety and trauma related symptoms in military veterans.

Methods

Veterans (N = 949) who went on military deployment and experienced a stressful event were genotyped for FAAH rs324420, CRHR1 rs110402 and CNR1 rs2180619. Anxiety and trauma symptoms were measured pre-deployment and 6 months after deployment. Anxiety was measured with the anxiety subscale of the Symptom Checklist-90 (SCL-90) and trauma with the Self-Rating Inventory for PTSD (SRIP).

Results

Covariance Pattern Models demonstrated no significant relation of genetic variations in FAAH rs324420 on anxiety and PTSD symptoms from pre-deployment to 6 months after military deployment. Additionally, we investigated interactions between the FAAH s324420, CRHR1 rs110402 and CNR1 rs2180619 polymorphisms. This also demonstrated no significant effects on anxiety and PTSD symptoms pre- to post deployment. However, the covariate of childhood trauma that was included in the models was significant in all these models.

Conclusion

Genetic variations in FAAH rs324420 and its interactions with CRHR1 rs110402 and CNR1 rs2180619 are not related to the development of anxiety and trauma-related symptoms. The study however, indicates the importance of considering childhood trauma in the investigation of the effects of polymorphisms that are related to the endocannabinoid system on the development of anxiety and PTSD symptoms.
A Loss Cycle of Burnout Symptoms and Reduced Coping Self-Efficacy: A Latent Change Score Modelling Approach
Authors: Koning-Eikenhout Liselotte M.J. , Delahaij Roos , Kamphuis Wim , Hulshof Inge L. , Van Ruysseveldt Joris
Published: October 2024

Police officers are frequently faced with chronic and acute stressors, such as excessive workload, organizational stressors and emotionally charged reports. This study aims to examine the relationship between a form of chronic strain (ie, burnout symptoms) and a resource (ie, coping self-efficacy) in a sample of Dutch police officers. Specifically, we aim to investigate the existence of a loss cycle of resources. We use Latent Change Score modeling to investigate the potential depletion or loss cycle of coping self-efficacy as a result of burnout symptoms in a sample of 95 police officers who completed a survey on three consecutive timepoints. The lag between the measurements was approximately one year. We found that, during both one-year intervals, within-person increases in burnout symptoms were related to within-person decreases in coping self-efficacy. Also, the results emphasize the buffering role of coping self-efficacy for burnout symptoms, as within-person decreases in coping self-efficacy during the first year were associated with within-person increases in burnout symptoms during the following year. Together, the results imply that a loss cycle of coping self-efficacy and burnout symptoms may occur. For this we used Latent Change Score modeling, which is a relatively new approach which provides researchers with the opportunity to analyse multi-wave longitudinal data while focusing on within-person changes over time. Practically, police organizations are advised to monitor personnel wellbeing and resources, to maintain and promote sustainable employability of police officers and to be able to timely provide individuals with interventions. Limitations discussed are the use of self-report measures and large intervals between the measurements. Finally, future directions of research are discussed that would circumvent the reported limitations, such as multiple wave with shorter lags and incorporating confounding factors that could affect coping self-efficacy.
Pharmacists’ perceptions of error reporting systems
Authors: Hartt Christopher Michael , Weigand Heidi , MacDonald Ashley Jean , Barker James R , MacKinnon Neil J
Published: October 2024

Background

Healthcare-related adverse events directly impact patient safety. Effective reporting of adverse events and workplace factors affecting the quality and quantity of reporting has been a recent focus. In Nova Scotia, pharmacists have been required to report quality-related events (QREs), errors, and near misses since 2010 through the Canadian Pharmacy Incident Reporting (CPhIR) database. This study aims to better understand how healthcare professionals who use the CPhIR system feel about their experience with QREs and the QRE reporting process.

Methods

A total of 1000 registered pharmacists and staff were contacted through the Nova Scotia College of Pharmacists. Five focus group meetings were conducted from May to October 2018, consisting of 17 community pharmacists, pharmacy technicians, and assistants.

Analysis

Thematic analysis was used to identify and define emerging themes in the transcripts by multiple readers. The Actor-Network Analytical Theory helped draw a web of connections in producing a safety culture that extends beyond the roles at the dispensing counter.

Results

It was found that participants were committed to minimizing and reporting errors, but using the CPhIR database system is both time-consuming and onerous. Additionally, there was a lack of continuity in communicating the QRE system protocols and compliance protocols for the system.

Conclusions

Community-based pharmacy culture needs to shift from a compliance-based culture, where error reporting is based on completion and volume, to a just culture that embraces quality and learning from mistakes, a critical element of safe dispensing.
Examining Homeless-Experienced Adults’ Smoking Cessation Treatment Use Pre- and Post-Entry into Permanent Supportive Housing
Authors: Harris Taylor , Panadero Talia , Hoffmann Lauren , Montgomery Ann Elizabeth , Tsai Jack , Gelberg Lillian , Gabrielian Sonya
Published: October 2024

Background:

Homeless-experienced adults smoke at rates 5 times that of the general adult population, and often have limited access to cessation treatments while homeless. Permanent Supportive Housing (PSH) can be a catalyst for cessation treatment utilization, yet little is known about use of these treatments following PSH entry, or how to tailor and implement cessation care that meets homeless-experienced adults’ vulnerabilities.

Methods:

Using Department of Veterans Affairs (VA) administrative data, we assessed smoking status (ie, current, former, non/never) among a cohort of homeless-experienced Veterans (HEVs) housed in Los Angeles-based PSH. We compared cessation treatment use rates (ie, nicotine replacement therapies, cessation medications, psychosocial counseling) pre- and post-housing using Chi-square tests. Predisposing (ie, demographics), enabling (eg, primary care, benefits), and need characteristics (ie, health, mental health, substance use diagnoses) were examined as correlates of cessation treatment utilization pre- and post-housing in univariable and multivariable logistic regression models.

Results:

Across HEVs (N = 2933), 48.6% were identified as currently-smoking, 17.7% as formerly-smoking, and 14.0% as non/never smoking. Among currently- and formerly-smoking HEVs (n = 1944), rates of cessation treatment use post-housing were significantly lower, compared to pre-housing, across all treatment types. Health, mental health, and substance use was more prevalent among currently- and formerly-smoking HEVs compared to non/never-smoking HEVs, and most diagnoses were positively associated with utilization univariably. However, in multivariable models, cessation clinic referrals and primary care engagement were the only significant ( P < .001) predictors of pre-housing and post-housing cessation treatment utilization.

Conclusion:

Among HEVs, we found high smoking rates and low cessation treatment utilization pre- and post-PSH entry. Efforts to educate providers about this population’s desire to quit smoking, support primary care engagement, and increase cessation clinic referrals may bolster their utilization. For homeless-experienced adults, optimizing cessation treatment accessibility by embedding cessation services within PSH and homeless service settings may reduce utilization impediments.
Understanding the “platform” keyword: An inquiry on the contested use of metaphors in platform studies
Authors: Cristofari Gianmarco
Published: October 2024

The emerging field of platform studies has sparked an ongoing debate regarding the meaning and utility of the term 'platform' within the academic community. This paper explores the contested nature of the term 'platform,' which has been employed as a metaphor, a conceptual framework for interpretation, and a keyword in digital discourse. The initial section traces the origins of platform discourse and the evolution of platform thinking. The second section utilizes cultural semiotics to reconstruct the metaphor's utility as a pragmatic instrument of knowledge. The third section delves into the contested meanings of the 'platform' by mapping twenty metaphors employed by scholars in diverse fields, including management, political economy, software studies, urbanism, and economic sociology. This section also organizes the metaphors in four conceptual categories related to the operations of the digital platform. The final part offers reflections on the 'platform' as a novel organizational form and assesses the overall usefulness of the term in academic discourse.
Open comments on Blok & Bruun Jensen's paper ‘What next for actor network theory? Inventing around Latour on a planet in distress’
Authors: Hennion Antoine
Published: October 2024

My comment mostly underlines the inadequacy of the tone of the paper, very critical about the way Latour has been criticized on one side, and somehow dogmatic on the other, in the way the authors present. Latour's propositions, from Actor Network Theory (ANT) to the Inquiry into the Modes of Existence (IME), though himself conceived them as proposals to be discussed, modified, criticized, something himself and Callon had done very early about ANT, in 1999.
Spatial distribution of damage potential of the 2023 Pazarcik Turkey earthquake using inelastic-response spectra of recorded and simulated ground motions
Authors: Zengin Esra , Bozorgnia Yousef , Tamhidi Aidin , Mazzoni Silvia
Published: October 2024

On 6 February 2023, a devastating earthquake of magnitude 7.7 struck the southeastern part of Turkey, followed by multiple aftershocks. The sequence of earthquakes caused extensive damage in Southern Turkey and Northern Syria. This study evaluates the destructive potential of ground shaking resulting from the Pazarcik mainshock by developing spatial distribution of inelastic demand spectra across the region by using the recorded ground motions. These spectra provide an additional step toward more realistic estimates of the damage potential of ground shaking than the traditional elastic response spectra. Given the recorded ground motions, we also developed simulated ground-motion time series at numerous un-instrumented sites. We used these recorded and simulated motions to estimate ductility demands across the affected area. Constant-ductility spectra were derived using recording stations within 100 km of the fault rupture. The results indicated that in the near-fault area, and for structural periods of 0.5 and 1.0 s, the yield strength demand at a ductility level of 3 exceeded the levels specified in the local seismic design code for a 475-year return period. Our findings demonstrate that with more refinement and efficiency of the ground-motion simulation approach, the development of near-real-time spatial distribution of ductility demand is a promising approach for rapid seismic damage assessment of earthquakes.
Failure of metabolic checkpoint control during late-stage granulopoiesis drives neutropenia in reticular dysgenesis
Authors: Wang Wenqing , Arreola Martin , Mathews Thomas , DeVilbiss Andrew , Zhao Zhiyu , Martin-Sandoval Misty , Mohammed Abdulvasey , Benegiamo Giorgia , Awani Avni , Goeminne Ludger , Dever Daniel , Nakauchi Yusuke , Porteus Matthew H. , Pavel-Dinu Mara , Al-Herz Waleed , Auwerx Johan , Morrison Sean J. , Weinacht Katja G.
Published: October 2024

Cellular metabolism is highly dynamic during hematopoiesis, yet the regulatory networks that maintain metabolic homeostasis during differentiation are incompletely understood. Herein, we have studied the grave immunodeficiency syndrome reticular dysgenesis caused by loss of mitochondrial adenylate kinase 2 (AK2) function. By coupling single-cell transcriptomics in samples from patients with reticular dysgenesis with a CRISPR model of this disorder in primary human hematopoietic stem cells, we found that the consequences of AK2 deficiency for the hematopoietic system are contingent on the effective engagement of metabolic checkpoints. In hematopoietic stem and progenitor cells, including early granulocyte precursors, AK2 deficiency reduced mechanistic target of rapamycin (mTOR) signaling and anabolic pathway activation. This conserved nutrient homeostasis and maintained cell survival and proliferation. In contrast, during late-stage granulopoiesis, metabolic checkpoints were ineffective, leading to a paradoxical upregulation of mTOR activity and energy-consuming anabolic pathways such as ribonucleoprotein synthesis in AK2-deficient cells. This caused nucleotide imbalance, including highly elevated adenosine monophosphate and inosine monophosphate levels, the depletion of essential substrates such as NAD+ and aspartate, and ultimately resulted in proliferation arrest and demise of the granulocyte lineage. Our findings suggest that even severe metabolic defects can be tolerated with the help of metabolic checkpoints but that the failure of such checkpoints in differentiated cells results in a catastrophic loss of homeostasis.
Health-related quality of life among women and men living with migraine: a Canada-wide cross-sectional study
Authors: Tam Alexander C.T. , Naik Hiten , Trenaman Logan , Lynd Larry , Zhang Wei
Published: October 2024

Background

Migraine is a prevalent neurologic disorder that affects women more than men. Examining health-related quality of life (HRQoL) by gender can aid decision makers in prioritizing future treatment and prevention programs. We aimed to quantify HRQoL by different levels of migraine disability and by gender.

Methods

As part of a Canada-wide cross-sectional study, we administered an online survey to employed adults who self-reported a diagnosis of migraine. Migraine disability level was assessed using the Migraine Disability Assessment questionnaire (MIDAS). MIDAS scores were used to categorize respondents as having little to no, mild, moderate, or severe level of migraine-related disability. Physical and mental component summary scores (PCS and MCS) and health utilities were derived from responses to the Veterans Rand 12 Item Health Survey. PCS, MCS, and health utilities were summarized by migraine-related disability levels and gender. Covariate-adjusted linear regressions were used to examine the association between migraine disability level and health utility by gender.

Results

A total of 441 participants completed the survey. The sample was predominantly women (60.1%), White race (75.5%), and had a mean age of 37 years. Mean health utility, PCS, and MCS scores were 0.61 (0.22), 45.0 (7.7), and 43.4 (11.0), respectively. All three scores decreased with increased migraine disability level. Gender differences on HRQoL within each migraine disability level were not statistically significant, except in the little to no disability level where women had lower mean MCS scores and health utility relative to men [mean (SD) MCS: women 44.0 (11.3); men 55.1 (8.1),p < 0.001; health utility: women 0.66 (0.18); men 0.81 (0.18),p < 0.001]. Linear regressions showed women with severe migraine-related disability had reduced health utility compared to women with little to no disability [adjusted difference: -0.16 (95%CI -0.24,-0.09)]. Associations among men increased in magnitude with migraine disability level [adjusted differences: mild − 0.16 (95%CI -0.24,-0.09); moderate − 0.18 (95%CI -0.26,-0.10); severe − 0.28 (95%CI -0.37,-0.20)].

Conclusions

Findings contribute to the literature on the association between migraine disability level and HRQoL by examining trends by gender. Model results emphasize the importance of future treatments reducing severe disability due to migraine among both women and men.
Understanding the impact of COVID-19 on mobility behavior of public transport passengers: the case of Metropolitan Area of Porto
Authors: Ferreira Marta Campos , Fernandes Hugo , Sobral Thiago , Dias Teresa Galvão
Published: October 2024

Public transport systems worldwide experienced significant declines in usage during the COVID-19 pandemic due to lockdowns and work-from-home mandates. While numerous studies have examined these phenomena, there is still a need for empirical evidence that not only documents what occurred but also provides actionable insights for future transport planning. This study aims to enhance understanding of public transport passengers’ mobility behaviors during different stages of the pandemic, using the Metropolitan Area of Porto, Portugal, as a case study. Automated Fare Collection data from 2020 were analyzed and compared with data from the pre-pandemic year of 2019. The analysis included temporal, spatial, spatio-temporal, and sociodemographic dimensions. Key patterns and trends identified include a rapid recovery of ridership post-restriction easing, homogenized daily travel patterns, varied impacts on different transport modes, and significant shifts in demographic travel behaviors. These findings highlight the resilience of public transport demand and suggest that adaptive scheduling, enhanced safety measures, targeted support for vulnerable groups, promotion of off-peak travel, investment in bus infrastructure, and encouragement of multi-modal transport are essential strategies. Implementing these strategies can help improve public transport planning and mitigate the adverse effects of future crises.
The effect of probiotic supplementation on non-alcoholic fatty liver disease (NAFLD) fibrosis score in patients attending a tertiary hospital clinic in Cairo, Egypt
Authors: Abd El Hamid Alaa Ahmed , Mohamed Azza Emam , Mohamed Manal sabry , Amin Ghada Essam El-Din , Elessawy Hagar Ahmed Ahmed , Allam Mohamed Farouk
Published: October 2024

Background

Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic fat accumulation (> 5% of liver tissue) in the absence of alcohol abuse or other chronic liver diseases. NAFLD can progress to non-alcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). This study aimed to assess the efficacy of probiotic (lactobacillus) supplementation on NAFLD fibrosis score.

Methodology

A double-arm randomized controlled trial was conducted in the family medicine clinic of a tertiary hospital, enrolling patients with sonographic evidence of NAFLD. Fifty patients were divided into two groups: the Probiotic group received lifestyle modification instructions along with daily probiotic supplementation for twelve weeks, with regular monthly follow-up visits. The Standard Treatment group received low-fat diet and lifestyle modification instructions only.

Results

The mean age of participants was 46.10 years (SD 10.11), with 70% females and 30% males. The study found a statistically significant difference in liver enzymes (ALT and AST) and BMI in the probiotic group before and after intervention. However, there was no significant difference in NAFLD fibrosis score between the two groups.

Conclusion

Short-term probiotic treatment resulted in improvements in ALT, AST, and BMI in the probiotic group, but did not significantly affect NAFLD fibrosis score. Further research with larger sample sizes and longer follow-up periods is warranted.

Trial registration

The clinical trial was registered at Protocol Registration and Results System with number NCT06074094 (12/09/2021).
The value of quantitative analysis of radionuclide bone SPECT/CT imaging in vertebral compression fracture: a retrospective study
Authors: Wang Yuhua , Qiao Feifei , Li Na , Liu Ye , Long Yahong , Xu Kang , Wang Jiantao , Zhang Wanchun
Published: October 2024

Background

Most patients with osteoporosis experience vertebral compression fracture (VCF), which significantly reduces their quality of life. These patients are at a high risk of secondary VCF regardless of treatment. Thus, accurate diagnosis of VCF is important for treating and preventing new fractures. We aimed to investigate the diagnostic and predictive value of quantitative bone imaging techniques for fresh VCF.

Methods

From November 2021 to March 2023, 34 patients with VCF were enrolled in this study, all of whom underwent routine 99mTc-MDP whole-body bone planar scan and local SPECT/CT imaging. The maximum standard uptake value (SUVmax) of 57 fresh VCF, 57 normal adjacent vertebrae, and 19 old VCF were measured. Based on the site of the fracture, fresh VCFs were regrouped into the intervertebral-type group and the margin-type group. Meanwhile, 52 patients who had no bone metastasis or VCFs in their bone scan were assigned to the control group. The SUVmax of 110 normal vertebral bodies and 10 old VCFs in the control group were measured.

Results

The median SUVmax of fresh VCF was 19.80, which was significantly higher than the SUVmax of other groups. The receiver operator characteristic (ROC) curve showed that the cut-off value of SUVmax was 9.925 for diagnosing fresh VCF. The SUVmax in the intervertebral-type group was significantly higher than that in the margin-type group (P = 0.04). The SUVmax of normal vertebrae was higher among patients than among the control group (P<0.01), but the CT HU value showed no significant difference.

Conclusion

The quantitative technique of bone SPECT/CT has a significant value in diagnosing fresh VCF. It can also determine the severity of fractures. In addition, whether the SUVs of the vertebrae adjacent to the fractured vertebra can predict re-fracture deserves further studies.