bluuebunny/crossref_metadata_2025 huggingface dataset:
Finite Element Analysis of Combined Energy Piles with Long and Short Heat Exchanger Tubes
Authors: Chen Shuaijiong , Deng Yuebao , Niu Shuai , Ming Wei , Chen Guannian , Zhang Rihong
Published: November 2023

To improve the heat exchange effect of energy piles in coastal areas, a new energy pile with a combination of long and short heat exchanger tubes is proposed. This technology combines the characteristics of implanted pile construction and arranges heat exchanger tubes of different lengths inside and outside the precast pipe pile, which can make full use of the geological conditions in coastal areas. Finite element analysis was applied for a project in a deep, soft soil ground to study the effectiveness of the new combined energy pile technology. The influences of the combined heat exchanger tubes and groundwater seepage conditions on the heat transfer and stress state of the energy pile were analyzed. The results show that the deformation and internal force of the pile body are closely related to temperature change. The temperature change is determined by heat transfer, which is closely related to the arrangement of heat exchanger tubes and underground water flow. With the increase of groundwater seepage velocity, the heat taken away by the heat exchanger tubes gradually increases; thus, the heat exchange between the heat exchanger tubes and the pile body decreases. The inner heat exchanger tube of the pile leads to an increase in heat exchange. However, as the length of the inner heat exchanger tube increases from 40 m to 80 m, the heat exchange decreases. The research results provide technical support for further development of the new energy pile technology.
The Influence of the Proportions of Titanium and Boron in the Al and AlSi7-Based Master Alloy on the Microstructure and Mechanical Properties of Hypoeutectic Silumin, AlSi7Mg
Authors: Lipiński Tomasz
Published: November 2023

Unmodified hypoeutectic silumins have a microstructure composed of large-sized phases, which are the reason for their low mechanical properties. Many years of research have shown the modifying effects of many chemical elements and their compounds, including the master alloy consisting of Al-Ti-B, often in the form of the finished AlTi5B alloy. In this work, it was decided to check how the proportions of Ti and B content in the Al or AlSi-based master alloy affect the microstructure and mechanical properties of a hypoeutectic silumin, AlSi7Mg. It has been shown that a master alloy containing silicon (with the participation of Al + Ti + B) has a more effective impact on the refinement of the microstructure, and thus an increase in the mechanical properties of the AlSi7Mg alloy, than a master alloy without silicon. It has been shown that the ratio of titanium to boron content in the very-often-used AlTi5B modifier is not always optimal. It has been shown that the use of a master alloy with a composition similar to that of modified silumin with titanium and boron in a 2:1 ratio allows the obtaining of an AlSi7Mg alloy with higher mechanical properties than the alloy after the modification of the AlTi5 master alloy.
Numerical Study of Endwall Modification with Micro-Scale Ribs in a Turbine Cascade
Authors: Liu Zhao , Song Yu , Lu Yixuan , Zhang Weixin , Feng Zhenping
Published: November 2023

A novel modification method, the ‘micro-scale’ rib, is proposed to expand cooling coverage for turbine endwalls. However, the introduction of the rib will inevitably affect the flow in the near-wall region. Therefore, the variation in the flow pattern for the traditional model of secondary flow needs further exploration. In this paper, to gain a clearer understanding of the micro-scale rib, the original endwall and three types of ribbed endwalls were adopted to numerically present the detailed flow, film cooling, and heat transfer information for the endwall surface and phantom cooling on the suction side (SS) of the blade. The Ansys code CFX was utilized to solve the 3D Reynolds-averaged Navier–Stokes (RANS) equations, and the SST k-ω was selected as the turbulence model after the verification. The results show that the rib-like vortex changed the flow of the coolant and had various impacts on the cooling characteristics. Although the cooling performance of the ribbed endwall improved, it also had a negative impact on heat transfer in most cases. Compared with the original, the vertical rib cases provided optimal film cooling, with increases of 26.9% and 17.4% for rib spacing values of 8 mm and 10 mm, respectively, with little difference in heat transfer (less than 1%). In addition, the horizontal rib cases presented the worse performance for both film cooling and heat transfer, which indicates that the rib layout should consider a mainstream flow direction for future designs.
Modeling, Prediction, and Results Correction of PDSH Circuits for Nanosecond Pulse Peak Detection
Authors: Shu Jun , Du Yi , Zhao Hui , Liu Kefu , Qiu Jian
Published: November 2023

The peak detect and sample hold (PDSH) circuit is an important component of the light detection and ranging (LiDAR) system, because the PDSH circuit can correct the walk error of the time discriminator, and distinguish different objects at the same location. However, due to the requirement for high-precision measurement of nanosecond-scale pulse signals, the design of the PDSH circuit presents significant challenges. This paper accomplishes the modeling of the PDSH circuit, including the modeling of the PDSH measurement speed and the voltage step, quantifies various factors that affect the PDSH circuit measurement results, and makes predictions based on the model. Through the derivation and simplification of the rise process in the PDSH circuit, this study establishes a mathematical model to predict the performance of the PDSH circuit. Furthermore, this study also investigates the effect of circuit delay time on the measurement speed of the PDSH circuit. Meanwhile, this study analyzes the voltage step process, and an equivalent circuit model is derived through theoretical analysis. By utilizing a fitting method, the equivalent capacitance value of the diode is obtained. The simulation and experiment results show that the errors between the measurement speed model of the PDSH circuit and the actual circuit are no more than 1.98 ns and 2.03 ns, respectively. Thus, the measurement speed model can accurately predict whether the PDSH circuit meets the requirements. Moreover, the maximum absolute error of the equivalent circuit model is 19.87 mV, which can significantly reduce the error caused by the voltage step.
The Potential of Green Engineering Solutions for Energy Conservation in Residential Buildings Towards Sustainability: A Case Study of Saudi Arabia
Authors: ALshabanat Abdullah , Omer Siddig
Published: November 2023

Developing countries in hot climate regions such as Saudi Arabia have witnessed rapid population growth, which has led to greater resource consumption as a result of the increased demand for new buildings. This research proposes a multi-objective evaluation of the potential green engineering solutions to conserve energy using a building within the ROSHN housing project, which is one of the mega projects in Saudi Arabia, as a case study for this paper with the aid of simulation software, taking into consideration the context of the sustainability concept. The results showed that traditional passive architectural design, whether courtyards or Mashrabiya, had the nearly greatest influence, with percentages ranging from −4% to −5.15% for varied parameters and designs compared to the base case energy usage. Furthermore, energy efficiency solutions for the building envelope’s external insulation and finish system (EIFS) enabled a drop in the U-value that lowered energy usage to −5.40%. However, the wall insulation thickness beyond 300 mm in this system has no substantial influence on energy savings. This research’s most clear finding is that a P2P system for PV panels on a district scale can supply enough energy to meet its needs after implementing the optimal strategy of the other proposed solutions.
Uniqueness Results for Some Inverse Electromagnetic Scattering Problems with Phaseless Far-Field Data
Authors: Zhu Xianghe , Guo Jun , Wang Haibing
Published: November 2023

Consider three electromagnetic scattering models, namely, electromagnetic scattering by an elastic body, by a chiral medium, and by a cylinder at oblique incidence. We are concerned with the corresponding inverse problems of determining the locations and shapes of the scatterers from phaseless far-field patterns. There are certain essential differences from the usual inverse electromagnetic scattering problems, and some fundamental conclusions need to be proved. First, we show that the phaseless far-field data are invariant under the translation of the scatterers and prove the reciprocity relations of the scattering data. Then, we justify the unique determination of the scatterers by utilizing the reference ball approach and the superpositions of a fixed point source and plane waves as the incident fields. The proofs are based on the reciprocity relations, Green’s formulas, and the analyses of the wave fields in the reference ball.
Managing Cybersecurity Threats and Increasing Organizational Resilience
Authors: Trim Peter R. J. , Lee Yang-Im
Published: November 2023

Cyber security is high up on the agenda of senior managers in private and public sector organizations and is likely to remain so for the foreseeable future. [...]
An Investigation of Acoustic Back-Coupling in Human Phonation on a Synthetic Larynx Model
Authors: Näger Christoph , Kniesburges Stefan , Tur Bogac , Schoder Stefan , Becker Stefan
Published: November 2023

In the human phonation process, acoustic standing waves in the vocal tract can influence the fluid flow through the glottis as well as vocal fold oscillation. To investigate the amount of acoustic back-coupling, the supraglottal flow field has been recorded via high-speed particle image velocimetry (PIV) in a synthetic larynx model for several configurations with different vocal tract lengths. Based on the obtained velocity fields, acoustic source terms were computed. Additionally, the sound radiation into the far field was recorded via microphone measurements and the vocal fold oscillation via high-speed camera recordings. The PIV measurements revealed that near a vocal tract resonance frequency fR, the vocal fold oscillation frequency fo (and therefore also the flow field’s fundamental frequency) jumps onto fR. This is accompanied by a substantial relative increase in aeroacoustic sound generation efficiency. Furthermore, the measurements show that fo-fR-coupling increases vocal efficiency, signal-to-noise ratio, harmonics-to-noise ratio and cepstral peak prominence. At the same time, the glottal volume flow needed for stable vocal fold oscillation decreases strongly. All of this results in an improved voice quality and phonation efficiency so that a person phonating with fo-fR-coupling can phonate longer and with better voice quality.
A Novel Image Processing Method for Obtaining an Accurate Three-Dimensional Profile of Red Blood Cells in Digital Holographic Microscopy
Authors: Kim Hyun-Woo , Cho Myungjin , Lee Min-Chul
Published: November 2023

Recently, research on disease diagnosis using red blood cells (RBCs) has been active due to the advantage that it is possible to diagnose many diseases with a drop of blood in a short time. Representatively, there are disease diagnosis technologies that utilize deep learning techniques and digital holographic microscope (DHM) techniques. However, three-dimensional (3D) profile obtained by DHM has a problem of random noise caused by the overlapping DC spectrum and sideband in the Fourier domain, which has the probability of misjudging diseases in deep learning technology. To reduce random noise and obtain a more accurate 3D profile, in this paper, we propose a novel image processing method which randomly selects the center of the high-frequency sideband (RaCoHS) in the Fourier domain. This proposed algorithm has the advantage of filtering while using only recorded hologram information to maintain high-frequency information. We compared and analyzed the conventional filtering method and the general image processing method to verify the effectiveness of the proposed method. In addition, the proposed image processing algorithm can be applied to all digital holography technologies including DHM, and in particular, it is expected to have a great effect on the accuracy of disease diagnosis technologies using DHM.
Simple Chemical and Cholinesterase Methods for the Detection of Nerve Agents Using Optical Evaluation
Authors: Břízová Aneta , Pitschmann Vladimír
Published: November 2023

The extreme toxicity of nerve agents and the broad spectrum of their physical and chemical properties, enabling the use of these agents in a variety of tactical situations, is a continuing challenge in maintaining the knowledge and capability to detect them, as well as in finding new effective methods. Despite significant advances in the instrumentation of the analysis of nerve agents, relatively simple methods based on the evaluation of colour signals (absorption and fluorescence), in particular those using the cholinesterase reaction, continue to be of importance. This review provides a brief presentation of the current status of these simple methods, with an emphasis on military applications, and illustrates the high interest of the professional community in their further development. At the same time, it also contains some peculiarities (high reliability and durability, resistance to extreme climatic conditions, work in deployed means of protection, low purchase prices, economic availability especially in a state of war, etc.) that the authors believe research and development of simple methods and means for the detection of nerve agents should respect.
Taking Action towards an Inclusive Career Counselling for Asylum Seekers and Refugees—A Literature Review Based on the PRISMA Model
Authors: Beqiraj Gresa , Ferrari Lea
Published: November 2023

Over the past decade, scholarly attention has increasingly focused on what is known as the ‘refugee gap’, which refers to the great difficulty asylum seekers and refugees face in entering the labour market in the host country. This poses a grave threat of social and occupational marginalisation for this group and highlights the role of systemic factors in facilitating resilience outcomes. By adopting a systemic perspective, this research aims to provide a critical reflection on the key features that should be considered when designing and implementing effective career counselling interventions for asylum seekers and refugees. To this end, a systematic review of the international applied research published by October 2022 has been carried out, using the PRISMA model. The 20 selected publications are grouped according to three main career research strands that reflect the core aspects to be addressed within career interventions in order to assist asylum seekers and refugees in their life and career transition in the host country, namely (i) psychosocial resources, (ii) identity transformation processes, and (iii) lived experiences and meaning-making processes. The main findings of the studies are discussed by looking into common themes that emerge from the literature, namely challenges related to migration contexts, self-regulating personal resources and skills, and sense of self and identity in career transitions, as well as considerations on the design aspects of career counselling and research targeting As&R. Finally, some guidelines and directions for action are provided for the purpose of developing inclusive career counselling interventions for As&R.
Views of Cross-Laminated Timber (CLT) Manufacturer Representatives around the World on CLT Practices and Its Future Outlook
Authors: Ilgın Hüseyin Emre , Karjalainen Markku , Mikkola Pinja
Published: November 2023

Due to its recent emergence, there is a limited body of global market research available on CLT. Presently, the literature lacks comprehensive understanding regarding the present state, varied uses, and future outlook of CLT construction at a global level. The objective of this article is to address this knowledge gap by conducting semi-structured, in-depth interviews with CLT manufacturer representatives around the world, including Austria, Italy, Czech Republic, Sweden, Norway, Finland, Japan, Canada, and Uruguay. Critical findings emphasized that (1) the predominant mention was about the insufficient knowledge and experience within construction professionals; (2) a clear need for heightened expertise and training in the domain of CLT was underscored; (3) CLT was regarded as a favorable choice in efforts to combat climate change; (4) CLT was deemed highly appropriate for settings marked by variable climatic conditions; (5) CLT producers, particularly those with comprehensive, vertically integrated operations encompassing the entire processing cycle, remained unaffected by the rise in raw material costs; (6) the COVID-19 pandemic generally yielded positive impacts on the CLT market; (7) primary application of CLT, as emphasized by most manufacturers, is in residential and institutional projects; and (8) most manufacturers noted the expansive and boundless opportunities within the market, especially considering the climate crises as potential future avenues for the utilization of CLT. This article aims to advance the widespread adoption of CLT within the global construction sector. It will achieve this by elucidating the obstacles, possibilities, and forthcoming prospects associated with CLT.
Measurement of the Diffusion Coefficient of Xenon in Self-Sintered Nanopore Graphite for Molten Salt Reactor
Authors: Li Pengda , Lei Qiantao , Zhang Heyao , Qi Mingbo , Song Jinliang , Lian Pengfei , Cheng Jinxing , Wang Qingbo , Tang Zhongfeng , Liu Zhanjun
Published: November 2023

The economics and safety of reactors can be affected by the diffusion of fission products into graphite. Xenon (Xe) fission products diffusing into graphite is the most critical neutron absorber and poison that can slow down or stop the chain reaction. The transport parameters for inhibiting the xenon diffusion in graphite are therefore an important scientific problem. Self-sintered nanopore-isotropic (~40 nm) graphite (SSNG) derived from green pitch coke can decrease Xe diffusion into graphite. In this study, the surface morphology and microstructural evolution in graphite before and after irradiation, as well as after annealing, were studied with different characterization methods. A method for the measurement of diffusion coefficients of fission products’ diffusion in graphite using Rutherford backscattering spectrometry (RBS) was also reported. The SSNG substrates were implanted with Xe at a dose of 4.8 × 1015 ions/cm2 and energy of 7 MeV. The RT-implanted samples were annealed in a vacuum at 650 °C for 9 h. The implanted and annealed samples were characterized using RBS. The diffusion coefficient D (Xe, 650 °C) was 6.49 × 10−20 m2/s. The results indicate SSNG’s excellent ability to inhibit Xe diffusion and are significant for designing and evaluating the safety of nuclear reactors.
Generating Novel and Soluble Class II Fructose-1,6-Bisphosphate Aldolase with ProteinGAN
Authors: Tang Fangfang , Ren Mengyuan , Li Xiaofan , Lin Zhanglin , Yang Xiaofeng
Published: November 2023

Fructose-1,6-bisphosphate aldolase (FBA) is an important enzyme involved in central carbon metabolism (CCM) with promising industrial applications. Artificial intelligence models like generative adversarial networks (GANs) can design novel sequences that differ from natural ones. To expand the sequence space of FBA, we applied the generative adversarial network (ProteinGAN) model for the de novo design of FBA in this study. First, we corroborated the viability of the ProteinGAN model through replicating the generation of functional MDH variants. The model was then applied to the design of class II FBA. Computational analysis showed that the model successfully captured features of natural class II FBA sequences while expanding sequence diversity. Experimental results validated soluble expression and activity for the generated FBAs. Among the 20 generated FBA sequences (identity ranging from 85% to 99% with the closest natural FBA sequences), 4 were successfully expressed as soluble proteins in E. coli, and 2 of these 4 were functional. We further proposed a filter based on sequence identity to the endogenous FBA of E. coli and reselected 10 sequences (sequence identity ranging from 85% to 95%). Among them, six were successfully expressed as soluble proteins, and five of these six were functional—a significant improvement compared to the previous results. Furthermore, one generated FBA exhibited activity that was 1.69fold the control FBA. This study demonstrates that enzyme design with GANs can generate functional protein variants with enhanced performance and unique sequences.
Correction: Winter et al. Z-Disk-Associated Plectin (Isoform 1d): Spatial Arrangement, Interaction Partners, and Role in Filamin C Homeostasis. Cells 2023, 12, 1259
Authors: Winter Lilli , Staszewska-Daca Ilona , Zittrich Stefan , Elhamine Fatiha , Zrelski Michaela M. , Schmidt Katy , Fischer Irmgard , Jüngst Christian , Schauss Astrid , Goldmann Wolfgang H. , Stehle Robert , Wiche Gerhard
Published: November 2023

The authors wish to make the following changes to their paper [...]
Chemistry of Hydrogen Sulfide—Pathological and Physiological Functions in Mammalian Cells
Authors: Andrés Celia María Curieses , Pérez de la Lastra José Manuel , Andrés Juan Celia , Plou Francisco J. , Pérez-Lebeña Eduardo
Published: November 2023

Hydrogen sulfide (H2S) was recognized as a gaseous signaling molecule, similar to nitric oxide (-NO) and carbon monoxide (CO). The aim of this review is to provide an overview of the formation of hydrogen sulfide (H2S) in the human body. H2S is synthesized by enzymatic processes involving cysteine and several enzymes, including cystathionine-β-synthase (CBS), cystathionine-γ-lyase (CSE), cysteine aminotransferase (CAT), 3-mercaptopyruvate sulfurtransferase (3MST) and D-amino acid oxidase (DAO). The physiological and pathological effects of hydrogen sulfide (H2S) on various systems in the human body have led to extensive research efforts to develop appropriate methods to deliver H2S under conditions that mimic physiological settings and respond to various stimuli. These functions span a wide spectrum, ranging from effects on the endocrine system and cellular lifespan to protection of liver and kidney function. The exact physiological and hazardous thresholds of hydrogen sulfide (H2S) in the human body are currently not well understood and need to be researched in depth. This article provides an overview of the physiological significance of H2S in the human body. It highlights the various sources of H2S production in different situations and examines existing techniques for detecting this gas.
Inorganic Green Pigments Based on LaSr2AlO5
Authors: Yamaguchi Kazuki , Takemura Akari , Furumoto Saki , Oka Ryohei , Masui Toshiyuki
Published: November 2023

La1.03Sr1.97Al0.97M0.03O5 (M = Fe, Co, Ni, and Cu) samples were synthesized using a citrate sol–gel method to develop a novel environmentally friendly inorganic green pigment. Among them, the Co-doped sample exhibited a vivid yellow, but not green. Then, (La0.94Ca0.06)Sr2(Al0.97Mn0.03)O5 was synthesized and characterized with respect to the crystal structure, optical properties, and color. The sample was obtained in a single-phase form and the lattice volume was smaller than that of the (La0.94Ca0.06)Sr2AlO5 sample, indicating that Mn ions in the lattice of the sample were pentavalent. The sample exhibited optical absorption at a wavelength below 400 nm and around 650 nm. These absorptions were attributed to the ligand, the metal charge transfer (LMCT), and d-d transitions of Mn5+. Because the green light corresponding to 500 to 560 nm was reflected strongly, the synthesized sample exhibited a bright green color. (La0.94Ca0.06)Sr2(Al0.97Mn0.03)O5 showed high brightness (L* = 50.1) and greenness (a* = −20.8), and these values were as high as those of the conventional green pigments such as chromium oxide and cobalt green. Therefore, the (La0.94Ca0.06)Sr2(Al0.97Mn0.03)O5 pigment is a potential candidate for a novel environmentally friendly inorganic green pigment.
New Zwitterionic Imidazolones with Enhanced Water Solubility and Bioavailability: Synthesis, Anticancer Activity, and Molecular Docking
Authors: Abu-Jabal Saber , Ghareeb Ahmad , Smadi Derar , Hamed Othman , Assali Mohyeddin , Berisha Avni , Abutaha Nael , Mansour Waseem , Omairah Ameed , Janem Alaa , Jaser Ataa
Published: November 2023

Finding an effective anticancer drug to combat cancer cell resistance remains a challenge. Herein, we synthesized a new series of imidazolone derivatives 4a–4i and assessed their anticancer activities against liver cancer cells (Hep3B), Hela cells, and normal LX2 cells. The imidazolne derivatives were synthesized by the condensation cyclization reaction using the natural product vanillin as a starting material. Among the synthesized imidazolones are those with an alkyl sulfate moiety that are water-soluble and showed enhanced anticancer activity against the tested cancer cells. The anticancer testing results showed that compound 4d with the NO2 group at position 4 of the benzene ring was superior to the other compounds; it showed an IC50 value of 134.2 ± 4.4 µM against Hep3B cells, while compound 4h with the pyridyl moiety showed the highest cytotoxicity against Hela cells with an IC50 of 85.1 ± 2.1 µM. The anticancer activity of some imidazolones was greatly enhanced by adding to them the zwitterionic properties that made them more polar and water-soluble. DNA binding studies with compounds 4a1, 4d, and 4g indicated a docking score ranging from approximately −6.8 to −8.7 kcal/mol. This could be attributed to the outstanding interaction between the molecule and the DNA binding sites, which primarily relies on its inherent capability to establish hydrogen bonds, facilitated by the electron pair present at the oxygen atoms and the drug’s amino group. In conclusion, water-soluble imidazolone with zwitterionic functionality could be a promising tool for the development of anticancer medication. To outline the general idea and the relationships for the effect of the developed compounds under study, as well as their mechanism of action, further extensive research is also necessary.
The dn Number in Transition Metal Chemistry: Its Utility and Limitations
Authors: Norman Nicholas C. , Pringle Paul G.
Published: November 2023

The dn number or configuration is a very useful parameter in transition metal chemistry because it conveys information about the expected properties of a d-block metal complex, including its shape, magnetism, thermodynamic stability, kinetic lability, and spectroscopic properties. The dn number can be determined from either the oxidation state (OS) or valence number (VN) of the metal centre, and since, in most cases, these are numerically equal, the derived dn value is the same. However, examples are discussed where the OS and VN are not equal, which results in unavoidable ambiguities in dn values. Following a discussion of these examples, a revised definition of dn is proposed based on the occupation of the frontier molecular orbitals of the complex.
Bioactive Pyrrolo[2,1-f][1,2,4]triazines: Synthesis, Molecular Docking, In Vitro Cytotoxicity Assay and Antiviral Studies
Authors: Mochulskaya Nataliya N. , Kotovskaya Svetlana K. , Butorin Ilya I. , Varaksin Mikhail V. , Charushin Valery N. , Rusinov Vladimir L. , Esaulkova Yana L. , Slita Alexander V. , Ilyina Polina A. , Zarubaev Vladimir V.
Published: November 2023

A series of 2,4-disubstituted pyrrolo[2,1-f][1,2,4]triazines containing both aryl and thienyl substituents were synthesized by exploiting the 1,3-cycloaddition reaction of N(1)-ethyl-1,2,4-triazinium tetrafluoroborates with dimethyl acetylenedicarboxylate. The antiviral activity of the synthesized compounds against influenza virus strain A/Puerto Rico/8/34 (H1N1) was studied in experiments on Madin-Darby canine kidney (MDCK) cell culture. Among the pyrrolo[2,1-f][1,2,4]triazine derivatives, compounds with low toxicity and high antiviral activity were identified. Dimethyl 4-(4-methoxyphenyl)-7-methyl-2-p-tolylpyrrolo[2,1-f][1,2,4]triazine-5,6-dicarboxylate was found to demonstrate the best antiviral activity (IC50 4 µg/mL and selectivity index 188). Based on the results of in vitro tests and molecular docking studies performed, a plausible mechanism of action for these compounds was suggested to involve inhibition of neuraminidase.
How Can Specialist Advice Influence the Neuroimaging Practice for Childhood Headache in Emergency Department?
Authors: Cappellari Alberto M. , Bruschi Gaia , Beretta Gisella B. , Molisso Maria T. , Bertolozzi Giuseppe
Published: November 2023

Differentiating between primary and secondary headaches can be challenging, especially in the emergency department (ED). Since symptoms alone are inadequate criteria for distinguishing between primary and secondary headaches, many children with headaches undergo neuroimaging investigations, such as brain CT and MRI. In various studies, the frequency of neuroimaging utilization is influenced by several factors, including teaching status, ownership, metropolitan area, insurance status, and ethnicity of patients. However, only a few studies have considered the role of specialist consultations in ordering neuroimaging studies on childhood headaches. We report the contributions of different specialists to the evaluation of children with headaches admitted to the ED and their influence on neuroimaging decisions. We retrospectively reviewed the medical reports of paediatric patients who presented with headaches to the paediatric ED of the Ospedale Maggiore Policlinico of Milano between January 2017 and January 2022. Overall, 890 children with headaches were evaluated (mean age: 10.0 years; range: 1 to 17 years). All patients were examined by the ED paediatricians, while specialist consultations were required for 261 patients, including 240 neurological (92.0%), 46 ophthalmological (17.6%), and 20 otorhinolaryngological (7.7%) consultations. Overall, 173 neuroimaging examinations were required, of which 51.4 and 48.6% were ordered by paediatricians and neurologists, respectively. In particular, paediatricians required 61.4% of brain CT scans, and neurologists required 92.0% of brain MRI scans. In conclusion, paediatricians were responsible for the management of most children with headaches admitted to the ED, while specialist consultations were required only in about a third of the cases. Although there was no significant difference in the number of neuroimaging studies ordered by specialists, brain CT scans were most often used by paediatricians, and MRI scans by neurologists.
Characteristics of Tuberculous Meningitis in HIV-Positive Patients from Northeast Romania
Authors: Loghin Isabela Ioana , Vâță Andrei , Miftode Egidia Gabriela , Cobaschi Mihaela , Rusu Șerban Alin , Silvaș George , Frăsinariu Otilia Elena , Dorobăț Carmen Mihaela
Published: November 2023

Background and objectives: One of the most severe forms of extrapulmonary tuberculosis (EPTB) is tuberculous meningitis (TBM), which is linked to significant morbidity and high mortality. It is well recognized that human immunodeficiency virus (HIV)-positive people are more likely to develop EPTB, including TBM, especially if they have severe immunodeficiencies. We aim to highlight the profile and the characteristics of TBM in HIV-infected patients. Material and methods: We conducted a retrospective clinical study based on hospital medical records of patients diagnosed with HIV/AIDS (acquired immunodeficiency syndrome) and TBM in Northeast Romania, hospitalized at “St. Parascheva” Clinical Hospital of Infectious Diseases of Iasi from 1 January 2010 to 1 December 2022. Results: From a total number of 1692 patients on record in our center, 195 had a HIV–tuberculosis (TB) coinfection, and 19 cases were HIV–TBM coinfected. Six cases were newly HIV-diagnosed late presenters, and thirteen patients’ names were already found in the center’s records with deficient immunological viral status (median CD4 lymphocyte level 47/mm3). The average age in the study group was 27 years old. The clinical manifestations and cerebrospinal fluid (CSF) variables were typical in most cases, despite the severe immunodepression of the patients. The Thwaites scoring system correctly identified 89.5% of the patients. The median admission period was 18 days; the lethality rate was 31.6%, despite access to ART and anti-TB drugs, and was associated with a more severe immunosuppression. No rifampicin resistance was detected. Conclusions: TBM appeared in a minority of our HIV cohort and affected severely immunodepressed patients; the clinical and CSF variables had a typical aspect in most cases, and the Thwaites scoring system performed well for this type of patient. The lethality rate was high and was correlated with a more severe immunodepression.
Effect of Water Magnetization Technique on the Properties of Metakaolin-Based Sustainable Concrete
Authors: Elkerany Ahmed M. , Elshikh Mohamed M. Yousry , Elshami Ahmed A. , Youssf Osama
Published: November 2023

Using metakaolin (MK) in concrete with magnetized water (MW) has a high possibility to enhance concrete suitability. In this study, the effect of using MK and MW on concrete characteristics was studied through testing twelve concrete mixes. Seven ratios of MK were used in this study, namely 0%, 5%, 10%, and 20%, as an alternative to cement and +5%, +10%, and +20% as a cement additive. In addition, five water magnetization methods were applied on MK concrete. In the first stage of this study, the impact of different MK ratios on the workability of concrete, compressive strength, flexural strength, and tensile strength was studied using traditional tap water (TW) as the concrete mixing water. In the second stage, the best mix (best MK ratio) from the first stage was chosen to study the effect of the water magnetization method on concrete properties and to determine the best method for water magnetization. Scanning electronic microscope (SEM) analysis was also carried out on selected mixes to closely investigate the effect of MK and MW on concrete microstructure. The results showed that the best ratio of MK in concrete was +10% (MK as a 10% cement addition), and the best water magnetization method was to pass the water through 1.6 tesla then through 1.4 tesla magnetic fields. The SEM analysis confirmed the absence of pores after using MW instead of regular TW by increasing the calcium silicate hydrate (CSH) gel and reducing calcium hydroxide (CH). Using MK and MW enhanced the compressive strength by up to 33%, 32%, and 27% at 7, 28, and 365 days, respectively, and MW enhanced the workability by up to 3% compared to that of the control mix.
Study on the Effect of Monoacrylic Monomers on the Polymer Network Morphology and Electro-Optical Performance of Reverse-Mode Polymer Stabilized Liquid Crystal Devices
Authors: Ma Cong , Wu Yishuo , Song Zhexu , Shi Yingjie , Xiong Guirong , Yu Meina , Gao Yanzi , Wang Qian , Zou Cheng , Xiao Jiumei
Published: November 2023

A polymer-stabilized liquid crystal (PSLC) device has been a promising candidate in several scenarios like smart vehicle windows and glass curtain walls in recent years due to its remarkable features like a fast switch from the initial transparent state to the scattering state with a rather low driving voltage, high transmittance at off-state, and broad viewing angle. The electro-optical characteristics of PSLC devices are determined by the synergistic attributions of liquid crystal (LC) molecules and the influence of the polymer network exerted on the movement of LC molecules. A systematic study of the influence of the polymer network on the movement of LC molecules is conducted, with the polymer network formed by methoxy/cyano/carboxyl monomers and diacrylate C6M. The polymer network morphology of PSLC film is greatly affected by the molecular structures and content of monoacrylic monomers. Additionally, the electro-optical performance and peel strength of PSLC films could be improved by modulating the molecular structures and morphology of polymer networks. PSLC devices containing carboxyl monomers show enhanced electro-optical performance and peel strength due to their directional filiform topology. This study might provide guidance for optimizing the performance of PSLC devices and establishing the relationship between the molecular structure, polymer network morphology, and electro-optical performance of reverse-mode dimming films.
Improved Huygens’ Principle for Metamaterial
Authors: Huang Wei , Liu Dan , Qu Xiaowei , Yin Shan , Ye Song , Zhang Wentao
Published: November 2023

In this paper, we propose a new method based on Huygens’ principle for calculations of transmission spectra with weak coupling and we call this method an improved Huygens’ principle. The original Huygens’ principle for metamaterial can only deal with transmission spectra without coupling between metamaterial structures. Our improved Huygens’ principle can give the approximate calculations of transmission spectra while considering coupling by employing the original Huygens’ principle. We demonstrate our method by employing full-wave simulations and experimental results.
On the Efficient Particle Dispersion and Transfer in the Fabrication of SiC-Particle-Reinforced Aluminum Matrix Composite
Authors: Du Andong , Lattanzi Lucia , Jarfors Anders E. W. , Zheng Jinchuan , Wang Kaikun , Yu Gegang
Published: November 2023

Lightweight SiC-particle-reinforced aluminum composites have the potential to replace cast iron in brake discs, especially for electric vehicles. This study investigates the effect of SiC particle size and matrix alloy composition on the resulting transfer efficiency and particle distribution. The performance of a specially designed stirring head was studied using a water model, and the stirring head conditions were assessed to understand the particle transfer and dispersion mechanisms in the molten aluminum. The standard practice of thermal pre-treatment promotes the wetting of the reinforcing particles and commonly causes clustering before the addition to the melt. This early clustering affects the transfer efficiency and particle dispersion, where their interaction with the melt top-surface oxide skin plays an important role. In addition, the transfer efficiency was linked to the particle size and the chemical composition of the matrix alloy. Smaller particles aggravated the degree of clustering, and the addition of rare earth elements as alloying elements in the matrix alloy affected the particle dispersion. The stirring parameters should be selected to ensure cluster disruption when the carbides are added to the melt.
Feedback on the Implementation of a Rapid and Connectable Point-of-Care COVID-19 Antigen Test in an Emergency Department
Authors: Coulon Caroline , Bargnoux Anne-Sophie , Jourdan Océane , Foulongne Vincent , Mondain Anne-Marie , Dupuy Anne-Marie , Sebbane Mustapha , Cristol Jean-Paul
Published: November 2023

Faced with the pandemic viral circulation of SARS-CoV-2, healthcare establishments have had to maintain an effective screening strategy in order to prevent nosocomial clusters. Automated antigenic tests appear to be a reliable and complementary alternative to RT-PCR (reverse transcriptase polymerase chain reaction) in order to optimize patient care in the emergency department. We report our experience of the deployment of the LumiraDx antigen tests on the LumiraDx platform, as well as the comparison of these tests’ results with the RT-PCR results on a population of patients sampled in the emergency department.
The Mediating Effect of Perceived Trust in the Adoption of Cutting-Edge Financial Technology among Digital Natives in the Post-COVID-19 Era
Authors: Chawla Udit , Mohnot Rajesh , Singh Harsh Vikram , Banerjee Arindam
Published: November 2023

The primary aim of this research is to thoroughly examine the determinants that influence customers’ intention towards embracing FinTech products and services, thereby enriching our understanding of the adoption and utilization trends within the FinTech industry in the aftermath of the COVID-19 pandemic. This is quantitative research in the context of India covering five major tech-savvy cities—Mumbai, Bengaluru, New Delhi, Pune, and Chennai. Using structural equation modeling (SEM), the mediation effect of Perceived Trust was examined in order to see the relationship between the retrieved constructs and their attributes. Predominantly, the data delve into the utilization of financial technology and the prevailing embrace of this transformative innovation by contemporary Indian society. From the findings, it has emerged that the three factors influencing Customer Intention to Adopt FinTech products are “Perceived Security”, “Perceived Risks”, and “Perceived Trust”. The significance of Perceived Security in the realm of defending against cyber risks and safeguarding personal information has been discovered to have a profound effect on individuals’ inclination to embrace FinTech. Likewise, acknowledging the potential risks and uncertainties that come with FinTech has proven to have a favorable impact on the intention to adopt. Notably, the perception of trust, which encompasses aspects such as the credibility of the company and the user-friendly nature of the technology, has been identified as a significant driver towards adoption.
Virtual Galleries as Learning Scaffolds for Promoting Problem-Based Learning
Authors: Papasarantou Chrissa , Alimisi Rene , Alimisis Dimitris
Published: November 2023

Extensive research into the effectiveness of problem-based learning (PBL) in primary and secondary education has been carried out over the past few years. PBL is an appealing, promising, but also challenging educational approach for both students and teachers. To overcome challenges, one of the most popular proposed strategies is to build learning scaffolds that gradually help students to effectively resolve the emerging sub-problems and tasks. Moreover, the massive impact of technology on students’ lives, and the transition from in-person to distance teaching (especially during the COVID-19 pandemic) highlights the necessity of using virtual worlds and digital tools to facilitate and amplify collaboration and communication, both synchronously and asynchronously. This paper introduces the virtual galleries method as a scaffold for applying PBL approaches in both physical and distance learning environments, within the field of STEM education. Virtual galleries are perceived as a practice that motivates learners to collaborate, express their ideas on solving a problem, and present them as interactive and immersive experiences, while allowing others (peer-learners and educators) to evaluate the produced solutions. In this context, it is argued that virtual galleries can facilitate PBL by serving as a conceptual framework for scaffolding the learning process, thus enabling the acquisition of new PBL-driven skills.
Purpose in Life in Higher Education: Is There a Role for Service-Learning?
Authors: Ribeiro Luísa Mota , Doroftei Alexandra , Miranda Francisca , Themudo Carmo , Dias Paulo , Peixoto Ricardo , Oliveira Ana , Correia Maria , Aramburuzabala Pilar , Rosário Pedro , Bringle Robert G.
Published: November 2023

The current study analyzed university students’ purpose in life in the context of service-learning (SL) courses developed in a university in Portugal. Briefly, 112 graduation and master students, from different areas, involved in 15 SL courses (82 female; 73.2%; age ranging from 18 to 51; M = 23; SD = 6.51) participated in this study. Questionnaires included an open-ended question about students’ purpose in life. Four closed-ended questions were included to understand student’s perceptions of change in their purpose in life arising from the SL courses and other perceptions about their SL course. Qualitative data were analyzed via content analysis with NVivo. Results indicated that students’ purpose in life ranged from social-related goals, such as helping or caring for others, to personal-related goals, including personal growth and well-being. Most of the students (71.4%) reported that their purpose in life changed moderately or a lot after participating in a SL course. Findings are discussed in light of the literature, identifying implications for the development of SL courses in higher education, considering the contribution of this pedagogic methodology to the definition and reconfiguration of young people’s purpose in life.
Talent Development Programs for Secondary Schools: Implementation and Evaluation of a Model School
Authors: Jöstl Gregor , Hinterplattner Sara , Rogl Silke
Published: November 2023

A school profile of talent development including model classes has been implemented at BG/BRG Keimgasse. This paper evaluates the impact of the actions taken by the school and compares the effects of both the model classes and the regular classes, with a school without a special focus on talent development. The aim of this study was to investigate the influence that the change in profile and teaching strategies had on both types of classes. This was conducted through initial qualitative interviews, followed up by quantitative questionnaires. It was found that the model classes had significantly higher scores in terms of school satisfaction, class climate, self-efficacy, mastery goal orientation, and in hope of successes, as well as scoring significantly lower on classroom pressure. This was achieved while shortening the education for the model-class students by one year and adding extracurricular activities. When comparing the regular classes at BG/BRG Keimgasse with classes from a regular school, the scores differed only slightly. This suggested that the concepts integrated at BG/BRG Keimgasse were successful in catering to the gifted students, without compromising the quality of the regular education.
Diets including Animal Food Are Associated with Gastroesophageal Reflux Disease
Authors: Baroni Luciana , Bonetto Chiara , Solinas Irene , Visaggi Pierfrancesco , Galchenko Alexey V. , Mariani Lucia , Bottari Andrea , Orazzini Mattia , Guidi Giada , Lambiase Christian , Ceccarelli Linda , Bellini Massimo , Savarino Edoardo V. , de Bortoli Nicola
Published: November 2023

Gastroesophageal reflux disease (GERD) is a clinical condition with a prevalence of up to 25% in Western countries. Typical GERD symptoms include heartburn and retrosternal regurgitation. Lifestyle modifications, including diet, are considered a first-line therapeutic approach. To evaluate the impact of life habits on GERD in this cross-sectional study, we used data collected through an online survey from 1146 participants. GERD was defined according to the Montreal Consensus. For all participants, clinical and lifestyle characteristics were recorded. Overall, 723 participants (63.1%) consumed a diet including animal food (non-vegans), and 423 participants (36.9%) were vegans. The prevalence of GERD was 11% (CI 95%, 9–14%) in non-vegans and 6% (CI 95%, 4–8%) in vegans. In the multivariate analysis, after adjusting for confounding factors, subjects on a non-vegan diet were associated with a two-fold increase in the prevalence of GERD compared to vegans (OR = 1.96, CI 95%, 1.22–3.17, p = 0.006). BMI and smoking habits were also significantly associated with GERD. This study shows that an animal food-based diet (meat, fish, poultry, dairy, and eggs) is associated with an increased risk of GERD compared to a vegan diet. These findings might inform the lifestyle management of patients with GERD-related symptoms.