bluuebunny/crossref_metadata_2025 huggingface dataset:
Echographic markers of combined pathology of uterus for women reproductive age
Authors: Sendetskiy Serhij
Published: January 2025

The objective: the women of reproductive age have a study of echographic features of the united pathology of uterus.Materials and methods. Were inspected 153 patients from adenomyosis in combination with the pathological processes of endometrium. The set clinical diagnosis of adenomyosis appeared the criterion of selection on the basis of careful analysis clinical-and-anamnestic, instrumental-diag-nostic and morphological information. In the cases when after complex clinical-and-instrumental and histological inspection the clinical diagnosis of adenomyosis caused doubts, this fact was the 7569 виченянхогречр 9а нфісенянхогбвід наукових досліджень до практики | Perinatology and reproductology:from research to practiceNo1 Vol. 4 • 2024ISSN 2788-6190ГІНЕКОЛОГІЯcriterion of exception. Fact of combination of adenomyosis with the leiomyoma of uterus by sizes 15 and more than weeks also was pregnancy the criterion of exception. Research echographic we applied as a screening instrumental method in diagnostics of adenomyosis for all inspected patients.Results. During the leadthrough of echography, taking into account development of adeno-myosis at the invasion of endometrium from a basale layer in a myometrium, and also taking into account the structural changes adjoining to endometrium areas of myometrium verified at morphology, the special attention was spared to the scan-out of the so-called «bordeline» area. The followings signs of echo appear during the detailed visualization of this area: an unclear limit is between a myometrium and endometrium; uneven bulge of «bordeline» area; a hetero-geneous structure of limit is a «endometrium- myometrium», where the hyperechoic including appear as shallow, more frequent than the rounded or linear structures. Bulge of back wall at adenomyosis, that is registered at ultrasonic research, it was marked in 68,2% cases, front wall – 32,4%, areas of bottom – 28,3%. Adenomyosis for all patients was diffuse. Adenomyosis of 2 degrees found out in a 1 group in 47,5%, in 2 groups – in 39,3%, in 3 groups – in 23,9%, and in 4 groups in 10,3% patients; adenomyosis of 3 degrees – in 52,5%, 61,1%, 76,1% and 90,2% patients respectively.Conclusions. Research echographic, especially with the use of coloured Doppler mapping, mat-ters very much in diagnostics of the united forms of adenomyosis and hyperplastic processes of endometrium. Correct interpretation of the got echographic results at this united pathology allows to develop rational tactic of conduct of such patients and conduct the adequate monitoring of medical process. The got results must be taken into account at development of algorithm of diagnostic and treatment-and-prophylactic measures. Keywords:united pathology of uterus, echography, markers, reproductive age.
Hysteroscopic estimation of the repeated combined pathology of uterus
Authors: Tolstanova Galina
Published: January 2025

The objective:to conduct the hysteroscopic estimation of the repeated combined pathology of uterus.Materials and methods. For the decision of the put purpose we were add to the retrospective analysis of hospital chart 128 women and to the prospective study a 171 patient with bleeding in a postmenopausal period. Among the retrospectively studied patients the selected group of comparison which consists of a 61 woman with the repeated combined pathology of uterus in a postmenopausal period (for comparison of methods of treatment of this contingent).Results.It is set that most authenticity of diagnostics of the combined pathology of uterus for the patients of postmenopausal age (97,3%) it was succeeded to attain the successive use these methods, while each of them separately could give diagnostic errors. Considerable part of coin-cidences of clinical and morphological diagnosis appeared confirmation of high diagnostic value of similar algorithm for the operated patients. In addition, to the algorithm of inspection of patients of this group, taking into account indisputable synchronicity of development of proliferative processes of sexual sphere of woman, it is necessary to include the adequate endoscopic inspection of endocervix and exocervix.Conclusions. Testifies the results of the conducted researches to the high degree of informing of hysteroscopic estimation of the repeated combined pathology of uterus for the women of post-menopausal period. The set features must be taken into account at development of algorithm of diagnostic and treatment-and-prophylactic measures for these patients.Keywords:combined pathology of uterus, relapse, hysteroscopy.
A role of age of patients is in the estimation of efficiency of assisted reproductive technologies at the combined forms of infertility
Authors: Mikievich Igor
Published: January 2025

The objective:to learn the role of age of women and men in the estimation of efficiency of assisted reproductive technologies (ART) at the combined forms of infertility.Materials and methods. 70 matrimonial pair of reproductive age, which made the followings groups, were inspected: basic (n=30), comparison (n=30) and control (n=10). In the complex of the conducted researches were included clinical, echographic, endocrinology, morphological, statistical and immunological which included determination of level of cytokines in a follicle liquid the method of the multiplexed analysis of albumens. Results. Findings testify that strengthening of secretion in the ovary of прозапальних cytokines can be one of mechanisms of unfavorable influence of stimulation of ovaries of gonadotropin on an oocyte. It is presently foreseen that stimulation of ovaries, its modes influence on «quality» of oocyte, potency of him to the impregnation and rates of early development of embryo. A negative role high concentrations can play in blood of estradiol, and also pharmacological preparations, which are used during stimulation of ovaries (gonadotropins, agonists and antagonists of gonadotropin-releasing hormone), and also eyelids of patients. The got results were confirmed by present fundamental pictures that co-operation between an oocyte and somatic cages of ovary is critical for normal motion of oogenesis, impregnation and early development of embryo, especially for the patients of older age. Conclusions. To informing clinical-and-anamnestic and hormonal factors which determine the result of cycle of ART for the patients of reproductive age with the combined forms of infertility, take: age of sick; index of mass of body; presence pipe peritoneal factor of infertility; a level of free testosterone is in blood; a table of contents of progesterone is in blood on 20–22 days of menstrual cycle, and also determination in the follicle liquid of ovaries of cytokines. By us the rotined role of age of patients in the estimation of efficiency of ART.Keywords:infertility, men, women, assisted reproductive technologies, age.
Influence of the combined pathology of uterus and mammary glands is on the reproductive function of women
Authors: Boyko Volodymyr , Sukhostavets’ Natalia
Published: January 2025

The objective: decline of frequency of violations of reproductive function for women with the combined pathology of uterus and mammary glands on the basis of study of new aspects of pathogeny of infertility, and also improvement and introduction of algorithm of diagnostic and treatment-and-prophylactic measures depending on the variants of the combined pathology of uterus and mammary glands.Materials and methods. The basic form of pathology of mammary glands, which is studied, was diffuse dysplasia of mammary glands. To the variants which are studied, of bening pathology of uterus we took the leiomyoma of uterus and adenomiosis. A leiomyoma of uterus was small sizes (to 12 weeks pregnancies) of intramural and subserosal localization. Adenomiosis was key or diffuse form of I-II of degree. Treatment of infertility all patients had conducted by the use of methods of assisted reproductive technologies. A 1 group was made by 90 women from diffuse dysplasia of mammary glands. Among them three sub-groups of women were selected taking into account the presence of concomitant genital pathology. In the complex of the conducted researches were included clinical, echographic, doppler, cardiotocographic, morphological, endocrinology, biochemical and statistical.Results. Presence only of bening dysplasia of mammary glands does not influence on the state of ovarian reserve, attachment of adenomiosis and leiomyoma significantly reduces ovarian reserve, which is confirmed by decrease of volume of ovaries, number of antral follicles, content of follicle-stimulating hormone, inhibin B and to the Antimüllerian hormone. Efficiency of the programs of assisted reproductive technologies for women with the combined pathology of uterus and mammary glands does not depend on application of different charts of stimulation of ovaries, use of assisted hatching, but depends on the state of the state of ovarian reserve and timely use of oocytes of donor. Total efficiency of treatment of infertility for women with of bening dysplasia of mammary glands is 53,3%; at combination from adenomiosisом – 33,3% and with a leiomyoma – 30,0% respectively. Conclusions. As results of the conducted researches, use of the improved algorithm of treatment-and-prophylactic measures rotined for women with diffuse dysplasia of mammary glands in combination with a leiomyoma and adenomiosisом allows significantly to promote efficiency of treatment of infertility for the women of group of high risk.Keywords:combined pathology, uterus, mammary glands, reproductive function.
Pressing questions of combined pathology of genitalia for the women of postmenopausal period
Authors: Vdovychenko Sergij , Sendetskiy Serhij
Published: January 2025

The objective: increase of efficiency of diagnostics and treatment of the combined pathology of genitalia for the women of postmenopausal period on the basis of improvement and introduction of algorithm of diagnostic and medical measures with the use of modern endoscopic methods.Materials and methods. Analysis of inspection and treatment 1830 patients in age from 55 to 80 years. As a result of complex clinical-and-laboratory and additional methods of researches next pathologies were selected for a separate study. Connected by pathology of endometrium – 853 from 1830 patients (46,6%); submucosal fibroids – 208 from 1830 patients (11,4%); combination of intramural-subserous fibroids from adenomyosis – 368 from 1830 patients (20,1%); of high quality new formations of ovaries – 133 from 1830 patients (7,3%); combination of pelvic organ prolapse with the combined pathology of genitalia – 129 from 1830 patients (7,0%).Results. In the structure of the combined of genital pathology for the women of postmenopausal period prevail the combined pathology of endometrium (46,6%); combination of intramural-subserous fibroids is from adenomyosis (20,1%); submucosal fibroids (11,4%); of high quality new formations of ovaries (7,3%) and combinations of pelvic organ prolapse are with different of genitalpathology (7,0%). Frequency of decompensated forms or malignant new formations of extragenital localization is 7,6%. The age-old aspects of the combined of genital pathology for the women of postmenopausal period are characterized by predominance of women of 55–64 (54,6%) by comparison to 65–74 (35,0%) and over 75 years old (10,4%). For women in age 55–64 years prevail the combined pathology of endometrium (41,2%) and combination of intramural-subserous fibroids from adenomyosis (26,7%) in comparing to submucosal uterine fibroids (13,4%); by of high quality new formations of ovaries (5,8%) and combination of pelvic organ prolapse with the combined pathology (6,1%). In age from 65 to 74 years for women prevail the combined pathology of endometrium (53,9%) and combination of intramural-subserous fibroids from adenomyosis – 83 from 641 sick (12,9%) in comparing to submucosal fibroids (9,7%); by of high quality new formations of ovaries (8,1%) and combination of pelvic organ prolapse with the combined pathology (8,6%). Conclusions. The results of the conducted researches testify to predominance of the combined genital pathology for the women of postmenopausal period. The offered is improved treatment-and-prophylactic and surgical measures, based on individual approach taking into account the concrete variants of the combined pathology, allow to promote efficiency of treatment, reduce frequency of relapse and improve quality of life of patients.Keywords:combined pathology of genitalia, postmenopausal period.
Women have the combined pathology of uterus with concomitant obesity
Authors: Kostikov Valery
Published: January 2025

The objective:the women of reproductive age have a study of risk factors of the combined pathology of uterus.Materials and methods. 397 women of reproductive age were inspected. Inclusion criteria are in research: presence of the combined hyperplastic processes of uterus – two and more for a disease (hyperplasia of endometrium, hysteromyoma and adenomyosis), verified morphologically, fertile age (18–45 years), absence in anamnesis of immunosuppressive therapy (6 months prior to entering into permanent establishment). Collection of anamnesis was conducted on the questionnaire – questionnaire which contains 120 points specially developed by us. The clinical methods of research included: general review on organs and systems, analysis of gynaecological status. Results. Detailing of anamnestic information demonstrates, that most specific gravity of risk factors distinguished representatives with combination of all variants of hyperplastic diseases of uterus, determining such potentially «unreliable» in a prognostic plan due to high-purity of the domestic inherited «load» on morbidity; to high infectious morbidity and, as a result – low index of somatic health (concomitant obesity, disease of the respiratory system and gastrointestinal tract); initially the unhappy state of the reproductive system: violation of menstrual cycle (protracted becoming of menstrual cycle (more than year), protracted and abundant menstruations) as reflection unfavorable endocrine-metabolic to the background; frequent artificial abortions which excel births on a quantity, post-abortion complications (bleeding and purulent-septic disease); high-purity of the carried inflammatory diseases of genitalia.Conclusions. The got results must be taken into account at development of algorithm of conduct of patients with the combined pathology of uterus in reproductive age. Keywords:combined pathology of uterus, tactician of treatment, obesity.
The women of the different age­related groups have clinical aspects of adenomyosis
Authors: Leshchova Olga
Published: January 2025

The objective: study of modern clinical aspects of adenomyosis. Materials and methods. An inspection was conducted 170 patients, from what 120 are patients of adenomyosis of different degree of activity and prevalence - basic group. A control group was made by 50 patients reproductive and premenopausal age without adenomyosis, which was added hysteгectomy with subsequent pathomorphological research of body of uterus concerning pelvic organ prolapse. To the complex of methods of researches were included clinical, laboratory, instrumental, morphological and statistical. Results. As a result of analysis of previous diagnoses on the prehospital stage for the patients of adenomyosis was discovered them considerable heterogeneity. From 120 patients in 49% this diagnosis was put correctly, in 18% adenomyosis by mistake was accepted for a hysteromyoma, in 11% – for hyperplasia and endometrial polyps, in 7% – after dysfunctional uterine bleeding; in 3% - at a ovarian cystadenoma. 9% patients long time inspected and treated oneself for a neurologist, gastroenterologist, internist with suspicion on hernia of disk, osteochondrosis, colitis, adhesive process and others like that. On the basis of clinical-and-anamnestic information and results of gynaecological inspection of adenomyosis was suspected in 95 patients, from them confirmed - in 56 cases. A part of pseudo-positive results was 41%. At the same time from 120 patients with confirmed adenomyosis, in a clinical diagnosis this pathology was taken away in 62, that part of pseudo-negative results was 48%, test-sensitivity – 51,7% and specificity – 59%.Conclusions. The got results specify in the presence of a few forms of this pathology, which must be taken into account in clinical to practice. The effective estimation of the got clinical results specifies on the necessity of improvement of existent algorithm of diagnostic and treatment-and-prophylactic measures for patients from adenomyosis.Keywords: adenomyosis, clinic, different age.
Women have medical­and­social aspects with natural menopause
Authors: Mitrinyuk Natalia
Published: January 2025

The objective:to learn medical-and-social features for women with natural menopause.Materials and methods. Conducted analysis of the clinical looking after 150 patients in age from 50 to 70 year with natural menopause. Groups made practically healthy women, which before an inspection, during the last year, did not accept a replacement hormonotherapy: a to 1 group entered 50 patients in age from 50 to 56 year, middle age 51,6±in 1,6; 2 groups are presented by 50 women in age from 57 to 65 year, middle age of 60,3±in 3,2; 3 groups consist of 50 inspected women in age from 66 to 70 year, middle age 67,4±1,9 year.Results. For the estimation of disorders of menopause, quality of life of inspection of women with natural menopause conducted with the use of traditional methods of research. Conclusions. The results of the conducted researches testify that patients had more heavy disorders of menopause in age 66–70 year – 42%, unlike 56–65 year – 18%, that underlines growth of metabolic violations with duration of postmenopause. Quality of life of women is related both to the features of person, social adaptation and with the degree of expressed of disorders of menopause. Suffer from loneliness of woman more senior in 66 – 40%, that worsens quality of their life. Considerably a necessity to treat oneself worsens a mood – «very experience» – 39% in age 50–56 year, it is «unpleasant» – 50%. Size of modified menopausal index higher for women which never were in marriage (r=0,76; p<0,01). Keywords: menopause, medical-and-social aspects.
Influence of assisted reproductive technologies is on clinical motion to a 1 trimester of pregnancy
Authors: Kitsаk Olga
Published: January 2025

The objective: to learn the comparative aspects of clinical motion of pregnancy for women after assisted reproductive technologies at infertility of different genesis in anamnesis. Materials and methods. 160 patients with infertility in anamnesis, pregnancy were inspected in which came as a result in vitro fertilization. In 34 from 160 patients after transference of embryos the noted development of ovarion hyperstimulation syndrome of different degree of severity. All patients were up-diffused on groups depending on the etiologic factor of infertility.Results. By us found out factors which are instrumental in reproductive losses in a 1 trimester of pregnancy for patients from pipe peritoneal by infertility in anamnesis: low body mass index, primary character of infertility and his duration more than 5 years, inflammatory genesis of impassable salpinxs. Additional factors of risk of reproductive losses in a 1 trimester at masculine infertility discovered it was not. It is set that in 2 from 3 patients pregnancy intermitted in 5–6 weeks on a type that stopped beating (anembryony). This fact, probably, is explained by inferiority of spermatozoa which are entered in the cytoplasm of ovule, forming genetically of anomalous embryos and is to the reflections of natural selection. Conclusion. The results of the conducted researches testify that early terms of pregnancy are «critical» for patients with infertility in anamnesis, regardless of his reason characterized by higher frequency of reproductive losses and threat of breaking as compared to II and by III trimesters of pregnancy. The risk of unfavorable result rises at development of ovarion hyperstimulation syndrome. The got results must be taken into account at development of algorithm of diagnostic and treatment-and-prophylactic measures. Keywords:assisted reproductive technologies, 1 trimester of pregnancy, complication.
Features of endocrinology and microbiological violations are in married couple in the estimation of efficiency of assisted reproductive technologies
Authors: Mikievich Igor
Published: January 2025

The objective:men and women have a study of features of hormonal status and state of microbiocenosis of urogenital tract from sterile married couple, plugged in the program of assisted reproductive technologies. Materials and methods. These inspections are in-process presented 250 men and women in age from 24 to 46 years (35,1±4,3), which are in sterile marriage. Duration of infertility in marriage varied from 2 to 16 years (6,5±2,1). In the etiopathogenetic structure of infertility a female factor appeared in 30% cases, masculine - in 10% cases, while combinations of the combined violations of reproductive function were diagnosed in most married couple (60%). In the complex of methods researches were included clinical, laboratory, instrumental, microbiological and statistical methods. Results. The analysis of hormonal function of ovaries rotined that certain differences are in the functional state of the reproductive system of patients and practically healthy women which are expressed in the reliable (p<0,05) decline of concentration of estradiol at 1,5 time in a periovulatory period (475,0±7,6 pmol/l and 710,2±10,5 pmol/l) and in diminishing of products of progesterone in the luteal phase of cycle (11,9±0,8 nmol/l and 35,1±1,2 nmol/l). At the estimation of results of bacteriologic examination from a cervical canal for the women of group of assisted reproductive technologies conditionally pathogenic microorganisms (Escherichia of coli, Staphylococcus, Streptococcus, Candida of albicans et cetera) found out in 87,3% cases. At the analysis of oscillation frequency sexually transmitted infections, it is marked, that them found out in 3,5% women, plugged in the program of assisted reproductive technologies.Conclusion. The results of the conducted endocrinology and microbiological researches in married couple testify to deeper than it is accepted to count, violation of reproductive function of and men, and women, plugged in the program. Thus, the representatives of married couple have violation of the neuroendocrine regulation the basic pathogenetic links of violation of reproductive function and microbiocenosis of the urinary system. The got results must be taken into account at development of algorithm of increase of efficiency of assisted reproductive technologies. Keywords:assisted reproductive technologies, married couple, endocrinology and microbiological violations.
Perinatal consequences for women with reproductive losses in anamnesis
Authors: Susidko Olena
Published: January 2025

The objective: to investigate perinatal consequences for women after assisted reproductive technologies and by reproductive losses in anamnesis. Materials and methods. In basis of work a complex inspection is fixed 100 pregnant after assisted reproductive technologies and them new-born (basic group). Group to comparison made 50 women of analogical age, in which pregnancy came in natural way. Middle age of pregnant in groups made 29,0±4,1 years and 33,1±3,3 for men. The protracted sterile period results in a volume, that the most favourable age missing for the offensive of pregnancy, and it comes in a late reproductive period on a background somatic and gynaecological diseases which accumulated. In the complex of the conducted researches were included clinical, echographic, doppler, cardiotocographic and endocrinology.Results. State of new-born at birth estimated after a scale Apgar. Middle estimation on 1 and differentiated 5 minute and made in a basic group 6,8±0,1, in the 5 minute 8,1±0,1; in the group of comparison – 6,4±0,2, in the 5 minute – to a 7,5±0,1 points (p<0,05). At the analysis of the state of new-born after a scale Apgar, we saw that in the group of comparison the more than 50% new-born had in the 1 minute an estimation after a scale Apgar less than 7 points, thus in 3 cases – there are less than 4 point. In the 5 minute in the group of comparison for certain greater there was an amount of children with an estimation less than 7 points as compared to a basic group 16,9% as compared to 2,9% (р<0,001). In the 1 minute the state of new-born on points was appraised as satisfactory (more 8–10 points) in a basic group in 53 (76,1%), in the group of comparison in 21 (35,5%) (р<0,001). A heavy stay in the 1 minute (4 point and less) was diagnosed only in the group of comparison in 3 (5,2%) new-born, that is conditioned by prematurity, hypoxia and functional immaturity of organs and systems.Conclusion. The analysis of the state and early adaptation of new-born from puerperas after assisted reproductive technologies rotined that perinatal results in a basic group and group of comparison had some differences which depend on expressed of initial pathological changes, from the variant of overcoming of infertility, from indemnification to extragenital pathology and, certainly, from the conduct of pregnancy, in particular from the grounded choice of charts of hormonal support.Keywords:perinatal consequences, reproductive losses in anamnesis.
Features of psychological description of women are with the combined forms of infertility
Authors: Shchedrov Andrey
Published: January 2025

The objective:a study of psychological features of women is with the combined forms of infertility.Materials and methods. By us 156 women were inspected, sufferings infertility, that appealed to the clinic of assisted technologies in treatment of infertility. All patients were inspected and on the basis of abnormal clinical-and-psychopathological an inspection on the criteria of International classification of diseases of a 10 revision was found out that a 81 woman suffered bordeline psychical disorders. A control group was made by 52 fertile mentally healthy women. In a group researches entered a 81 woman with bordeline psychical disorders which appealed for the contacted of assisted reproductive technologies with the second infertility. To all patients it was conducted complete clinical-and-laboratory inspection on a chart, accepted in the clinic of assisted technologies in treatment of infertility. For the estimation of psychological status of patients studied the followings indexes: Lazarus and Folishan test; index of vital style; a Leongard questionnaire and Beсk depression inventory.Results. More frequent all the women of the investigated group remembered a surprise, concern, anger, loneliness, offense, depression, inadequate conduct at the estimation of feelings, when first ran into a question about absence of offensive of pregnancy. Question which belongs more frequent all: «Why I?», «Why with me so did it happen?». Counted the more than half of women, that pregnancy all the same would come independently, and did not apply for treatment many years. From it spoke to the doctor in age more senior 35 years 37,0% women of the investigated group. Adequate position in relation to treatment modern methods registered in the group of patients 25–30 years in 12,0% patients. A tendency is traced, that in the investigated group the more than half of patients freely discusses the problems of infertility with a partner, practically all feel support of partner, half mark mutual relations warm, satisfaction in sexual contacts in the more than half of all women. A cross-correlation analysis was rotined by positive influence of positive relation in families and offensives of pregnancy.Conclusions. Combination of a few factors assists development of bordeline psychical disorders, such as a non-adaptive conduct, which was instrumental in strengthening of internal tensiondisfunction of the vegetative nervous system, that appeared in vegetative violations. Protracted internal tension resulted in development of high level of alarm, extrass of corticosteroids in future to the immunodeficient state, that was instrumental in intensifying of chronic somatic illness. Coping strategy «escape in illness» resulted in development of psychosomatic diseases the primary objective of which was avoidance of treatment. The got results must be taken into account at development of algorithm of diagnostic and treatment-and-prophylactic measures.Keywords: infertility, combined forms, psychological status.
Clinical aspects acne for the women of early reproductive age
Authors: Kosyuta Myroslava
Published: January 2025

The objective: to learn clinical aspects acne for the women of early reproductive age. Materials and methods. As a result of screening inspection in research 50 patients entered from acne different degree of severity. All patients produced complaints on acne in the area of person, and 10 women (20,0%) also and in the area of breasts and back. Rashes, as a rule, were not accompanied by the subjective feelings, after a liquid exception, when separate elements were sickly at palpation. In addition, 39 patients (78,0%) marked the enhanceable facial skin greasiness and scalp. Age of the investigated patients ranges from 18 to 25 years. To the complex of the conducted researches clinical, laboratory, instrumental and statistical methods were included. Results. Found out for certain reverse cross-correlation dependence between the initial values of diagnostic index acne and age of patients acne (r=-0,34; p=0,023). Thus, the considerably less initial values of diagnostic index acne (less than 5) found out more than in the halves (73,3%) of women in age 20–25, and less than in the fourth (20,0%) of patients under age 20. By us reliable dependence of severity of motion was set acne from the inherited factors: more heavy degree acne registered in a sub-group patients in which in domestic anamnesis acne were for a mother r=0,555; p=0,015) and for brothers and sisters (r=0,921; p=0,000) and easy degree – for a father. The certain tendency of direct dependence of severity acne from duration of morbidity, however reliable information it is not got. At a gynaecological inspection except for bimanual research and ultrasonic research of organs of small pelvis (for the exception of gynaecological pathology) determined a hirsutic number for patients from acne. Hirsutic number for patients acne from 10 to 25 point hesitated scope on the scale of Ferrimana-Gollveya, median 16,2. Findings testify that expressiveness of hirsutism for certain is associated with the factors of heredity (r=0,448; p=0,021), and also, that the degree of severity acne does not correlate with manifestations of hirsutism. Direct cross-correlation dependence of degree of expressiveness of hirsutism and duration of disease (r=0,616; p=0,003) which confirms influence of androgens on duration of dermatosis and absence of nosotropic meaningfulness of expressiveness and severity acne is set.Conclusions. The results of the conducted researches testify that findings must be taken into account at development of algorithm of diagnostic and treatment-and-prophylactic measures. Keywords: acne, clinical aspects, early reproductive age.
The women of young age have features of treatment of submucosal uterine fibroids
Authors: Leshchova Olga
Published: January 2025

The objective: The women of reproductive age have an increase of efficiency of diagnostics and treatment of submucosal uterine fibroids on the basis of study of clinical-and-echographic, endocrinology and immunohistochemical features, and also development and introduction of the improved algorithm of diagnostic and treatment-and-prophylactic and rehabilitation measures with the use of modern endoscopic technologies and directed medicinal correction. Materials and methods. A complex inspection is conducted 60 women which a conservative myomectomy was conducted. In the complex of the conducted methods researches were included: behind-the-scenes clinic inspection; clinical-and-laboratory methods of diagnostics; echography of organs of small pelvis; hysteroscopy; separate diagnostic scraping the mucous membrane of the cervical canal and cavity of uterus with subsequent morphological research; immunohistochemical methods of study of biomolecular markers. For the estimation of remote consequences were analysed clinical-and-laboratory indexes in 60 women after a conservative myomectomy, which were up-diffused on two groups: a to 1 group entered 30 patients in which operative treatment was conducted on the method improved by us, and also which hormonal preparations were appointed taking into account immunohistochemical of information; 2 groups were made by 30 women, operated on the generally accepted method and recipient treatment only on the basis of morphological research of myoma and endometrium. Results. The results of immunohistochemical researches of remote myomatous nodes testify that in their tissue receptor dependence on estrogen absents in 56,7%; weak – in 26,7%; moderate – in 10,0% and strong – in 6,7% supervisions. In the structure of expression of receptors on progesterone the moderate (36,7%) prevail and strong (36,7%) in comparing to weak (20,0%) and its absence (6,7%). The use of the algorithm of rehabilitation measures improved by us allows to reduce frequency of pain syndrome on 36,7%; violations of menstrual function on 33,3%; prophylaxis of relapses of disease (during the generally accepted rehabilitation – 8,3%), and also on 18,0% to promote efficiency of proceeding in a reproductive function as an offensive of pregnancy.
Conclusions.The conducted analysis of the nearest and remote results of submucosal myomectomy rotined that a myomectomy was the expedient and effective surgical method of treatment. The use of less invasion endoscopic accesses on the algorithm improved by us is instrumental in more «smooth» motion of postoperative period, abbreviates the terms of stay of patients in permanent establishment, that in combination with an endocrinotherapy, appointed taking into account immunohistochemistry endo- and myometrium, instrumental in normalization of menstrual function and creates favourable terms for realization of reproductive function of woman.Keywords:submucosal uterine fibroids, treatment, young age, reproductive function.
Pressing questions of pathogeny of combination of genital endometriosis and hypothyroidism
Authors: Netskar Iryna
Published: January 2025

The objective: to set the features of pathogeny of genital endometriosis of hypothyroidism.Materials and methods. By us it was inspected 110 patients of reproductive age from 20 to 41 year with external genital endometriosis. All women parted on two groups. In the first group 50 patients entered with external genital endometriosis without pathology of thyroid, in a friend – 60 women with external genital endometriosis and concomitant hypothyroidism.The clinical groups of patients are formed thus: the first group was made 10 (20%) patients which treated oneself concerning infertility and during an inspection there were found out the hearths of external genital endometriosis on the peritoneum of small pelvis; that 15 (30%) appealed to the gynaecologist with complaints about dysmenorrhea, dyspaurenia, pains in the area of pelvis and at a complex inspection was found out external genital endometriosis; 25 (50%) patients which acted on the planned operative treatment concerning the endometrioid ovarian cysts.To the complex of the conducted researches were included clinical, echographic, immunological, endocrinology and statistical methods.Results. Secretion of thyrotropic hormone for women with external genital endometriosis and with subclinical and by a manifest hypothyroidism was considerably (р<0,01) more high as compared to such in the group of patients with external genital endometriosis without pathology of thyroid, and also higher than normative indexes. At obvious or manifest hypothyroidism together with the increase of level of thyrotropic hormone the reduced level of fT4 is determined (free thyroxine). The hyperproduction of thyrotropic hormone for patients with external genital endometriosis at hypofunction of thyroid are instrumental in diminishing of level of follicle-stimulating hormone to the increase of products of prolactin, that results in the decline of estrogen-producing function of ovaries.Conclusions. The results of the conducted researches testify to the substantial role of endocrinology status in pathogeny of external genital endometriosis on a background a hypothyroidism. The got results must be taken into account at development of tactic of conduct of these patients.Keywords:genital endometriosis, hypothyroidism, pathogeny, pressing questions
Actual aspects of dysbiosis vagina for the women of reproductive age from trichomoniasis to pregnancy
Authors: Prishchepa Andrey
Published: January 2025

The objective: determination of laboratory and clinical features of development of trichomonas vaginal dysbacteriosis. Materials and methods. Under our supervision were 94 unpregnant women in age from 17 to 39 years (middle age 27,04 ± in 0,76), which take the course of inspection and treatment concerning acute urogenital trichomoniasis. A control group (first group) was made 95 healthy unpregnant women of reproductive age. In the second group (52 women) there were the included patients, suffering from acute trichomoniasis. To 42 patients after the conducted course of antiprotozoal therapy, an inspection with the purpose of determination of conformities to law of forming of trichomonas vaginal dysbacteriosis was conducted (third group). To the complex of the conducted researches were included clinical, microbiological, virological, biochemical and statistical. Results. Acute trichomonas invasion is the factor of unbalance of all element of microecosystem of vagina which leads to forming of terms for development of trichomonas vaginal dysbacteriosis. At trichomonas vaginal dysbacteriosis reliable changes take place in functional activity of epithelium, biochemical composition of vaginal liquid, microbiological concord of vagina. For certain meaningful changes in composition a vaginal liquid are certain in content of urea, general albumen, iron and copper, activity of enzymes, level of рН of vaginal liquid and virality of amine test. Acute trichomonas invasion results in violations of factors of heterospecific resistance of microecosystem of vagina. A preservation of concentration of sIgA at the level of values of norm is prognostic a favourable sign in the plan of normocenosis of vaginal microecosystem.Conclusions. The got results it must draw on for effective diagnostics and treatment of trichomonas vaginal dysbacteriosis.Keywords: vaginal dysbiosis, reproductive age, trichomoniasis, pregnancy.
A manufatura enxuta no contexto da defesa nacional aplicada em indústrias de defesa e forças armadas: uma revisão integrativa
Authors: Gomes Hanameel Carlos Vieira , Miceli Junior Giuseppe , Cunha Antonio Eduardo Carrilho da
Published: January 2025

Este trabalho tem por objetivo apresentar as contribuições da manufatura enxuta no contexto da defesa nacional, a partir de uma revisão integrativa da literatura voltada para aplicações em indústrias de defesa e Forças Armadas, e identificar oportunidades de integrá-la ao Exército Brasileiro. A revisão integrativa da literatura destacou 27 artigos, em que organizações militares e indústrias de defesa do mundo todo têm se beneficiado da aplicação dos princípios e ferramentas da manufatura enxuta, na medida em que elimina ou reduz desperdícios de processos, principalmente relacionados com a espera entre atividades e processamentos desnecessários, alcançando melhores resultados na entrega dos seus bens e serviços. Destaca-se o Mapeamento de Fluxo de Valor (MFV) como a principal ferramenta da manufatura enxuta para o aperfeiçoamento de processo e aplicação eficiente dos recursos. As oportunidades de integrá-la ao Exército Brasileiro são primariamente identificadas nos processos de manutenção, modernização e revitalização de Sistemas e Materiais de Emprego Militar (SMEM), podendo ser aplicada em outros ambientes como, gestão hospitalar, de obras militares, organizacional, de projetos, do ciclo de vida de SMEM e logística de suprimentos.
A Comprehensive Review of Time-Domain Approaches for Chatter Dynamics and Forced Vibration Analysis in Thin-Walled Milling
Authors: Dheeraj S. Lengare
Published: January 2025

Chatter is a prevalent self-excited vibration phenomenon that occurs in most milling procedures and substantially affects surface quality, tool life, and productivity. This paper discusses time-domain methods for modeling chatter dynamics and forced vibration in thin-walled milling, mainly focusing on prediction, detection, and control techniques. To deal with the chatter phenomenon, theoretical factors affecting chatter, such as process damping, tool run-out, and gyroscopic effects, are discussed to gain insight into their influence on stability prediction. This paper reviews models for milling force prediction with the prospective application of these models to thin-walled structures. It further questions the established experimental methods, such as finite element modal analysis or structural coupling, for obtaining frequency response functions of workpieces and tools. Advances and performances of hardware in the loop simulation study deal with the reflection of mirror-milling technology development aimed at application to performing thin-walled part components. The review discusses the root causes of chatter and provides the path for future work to further improve prediction accuracy and suppression methodologies. This contributes to the sustainable planning of successful thin-walled milling processes with improved characteristics and machine output.
An Analysis of the Role of Religion in Impulsive and Obligatory Online Purchasing of Islamic Clothing
Authors: Seyyed Hassan Hataminasab
Published: January 2025

Religious consumers may have different preferences for online shopping based on their religious motivations, and individual and contextual factors can influence their behavior. Specifically, there is a hypothesis that other individuals affect the decision-making of religious consumers in their social environment; moreover, individual factors, like a tendency toward future-oriented thinking, also play an important role in their online shopping decisions. In this study, the researcher aims to examine the impact of religion on impulsive and obligatory online shopping behavior with regards to the mediating role of individual sensitivity. The research method is descriptive and survey-based, using a questionnaire as the tool, and the statistical population consists of consumers of Islamic clothing in Yazd. Analysis of the hypotheses using structural equation modeling showed that individuals' beliefs significantly impact their tendencies for impulsive online shopping of Islamic textiles, but it does not lead to obligatory purchases. Conversely, external religiosity has a significant role in obligatory purchases, but it cannot generate impulsive online shopping behavior.
Artificial Intelligence Governance in the European Union
Authors: Ali Karami
Published: January 2025

The European Union has taken an active stance in regulating AI through legislative initiatives, ethical guidelines, and consultation with stakeholders (European institutions, companies and governments) and aims to lead the global AI landscape by balancing AI advances with the social values ​​of citizens. Through AI governance, the Union seeks to create a regulatory framework that promotes innovation while ensuring the protection of fundamental rights, safety, and the public interest. This article aims to examine the EU mechanisms for AI governance. The main research question is what are the most important salient features of the AI ​​governance model in the EU? Given the qualitative nature of the subject, the research method is descriptive-analytical. The required data will be collected by referring to EU AI documents and laws such as the AI ​​Law, the General Data Protection Regulation, ethical guidelines, the European AI Strategy, the Data Governance Law, the AI ​​Coordination Plan, and the EU AI Supervisory and Enforcement Mechanisms. The paper's findings show that while the EU is progressing in AI governance, it faces challenges in harmonizing member states’ regulations, attracting global cooperation, navigating the rapidly evolving AI landscape, and balancing innovation with ethical standards. The paper’s findings show that the EU AI governance model focuses on creating a regulatory framework that encourages innovation and oversees the development of AI so that it is used in a way that is consistent with European values ​​such as protecting fundamental rights, ensuring transparency, and promoting accountability.
The European Union's Approach to Cognitive Warfare’s Command and Control
Authors: Ali Karami
Published: January 2025

Cognitive warfare has evolved alongside advances in technology, psychology, and communication methods, reflecting a growing understanding of how to influence and control human minds. Cognitive warfare refers to efforts to influence, manipulate, or control public perceptions, decision-making processes, and behaviors using psychological, informational, or technological tactics that often blur the lines between the military and civilian domains. From ancient psychological tactics to artificial intelligence-based disinformation campaigns, the essence of cognitive warfare is the same: shaping perceptions and behavior in ways that often achieve strategic goals without the need for physical force. One of the most important aspects of cognitive warfare is its command and control, which naturally has multiple perspectives. This article aims to understand the European Union’s approach to command and control of cognitive warfare. The main research question is what similarities and differences does the European Union’s approach to command and control of cognitive warfare have with other approaches? The method of this article is descriptive-analytical. The required data was obtained by referring to library sources as well as reputable scientific research articles and official documents. The research findings show that the European Union's approach to command and control in cognitive warfare is shaped by its broader strategy for hybrid threats, cybersecurity, and defense, with a focus on resilience, collective security, and democratic values. The European Union's approach to command and control in cognitive warfare integrates multi-level efforts to protect information integrity, increase public resilience, and promote digital governance while respecting democratic values. Also, in the Union's approach, cooperation with international partners and continuous development of capabilities in command and control of the growing domain of cognitive warfare is crucial.
The Role of Information and Communication Technology in Promoting Quranic Culture
Authors: Mahdi Dolati
Published: January 2025

The author begins this speech by examining the impact of information and communication technology on understanding the Quran, including: easy storage and retrieval of information, establishing communication in cyberspace, and preserving old manuscripts. After that, he points to solutions for optimal use of the Internet in promoting Quranic culture in two ways: one: referring to search engines. Second: referring to subject classification spaces on the Internet. Then, under the title of optimization solutions for recognizing and accessing Quranic information, he states four of these solutions. Pathology - communication of Quranic websites and blogs, including not being updated and biased, and then optimization solutions for these sites and blogs, such as audience-centered answering questions, paying attention to the global dimensions of the Quran, developing specialized and thematic (group) blogs, is another title; and finally, the author's specific suggestions conclude the speech.