bluuebunny/crossref_metadata_2025 huggingface dataset:
Pars Plana Vitrectomy in Tuberculous Endophthalmitis: A Case Report
Authors: Markov Gueorgui , Nikolina Andonova  , Yani Zdravkov  , Alexander Oscar
Published: August 2023

Introduction: Ocular tuberculosis (TB) is an extrapulmonary mycobacterial disease with varied manifestations. Endophthalmitis is a severe manifestation with a rapid progression that may lead to intraocular tissue destruction and panophthalmitis. This study aimed to report a case of tuberculous endophthalmitis treated with pars plana vitrectomy (PPV).

Case presentation: A 57-year-old male patient with TB endophthalmitis. The follow-up period was 6 months. The diagnosis was made on a clinical basis, and the specific etiology was confirmed by TST and IGRA tests. The diagnosis of ocular TB was delayed by one year. He had bilateral endophthalmitis with severe inflammation. The right eye (OD) was blind, and the left (OS) had best-corrected visual acuity (BCVA) of hand motion. Intraocular pressure (IOP) was elevated in both eyes. B-scan disclosed hyperreflective exudate, filling 1/3 of the vitreous cavity in OD, and vitritis and intravitreal hemorrhage in OS. We commenced triple antitubercular therapy. 23G PPV with silicone oil and phacoemulsification with IOL implantation were done. The intraocular inflammation in OS decreased postsurgically, and in one month, BCVA was 20/200 and IOP was within normal limits.

Conclusion: Eendophthalmitis is an indication for therapeutic vitrectomy. The risks of surgery seem to be lower than the benefits, including a decent chance for visual improvement and avoidance of enucleation. In our case, 23G PPV with phacoemulsification seemed to be beneficial in decreasing the level of inflammation, improvement of visual acuity, reduction of IOP, and preservation of the eye.
pyWitness 1.0: A python eyewitness identification analysis toolkit
Authors: Mickes Laura , Seale-Carlisle Travis M. , Chen Xueqing , Boogert Stewart
Published: August 2023

pyWitness is a python toolkit for recognition memory experiments, with a focus on eyewitness identification (ID) data analysis and model fitting. The current practice is for researchers to use different statistical packages to analyze a single dataset. pyWitness streamlines the process. In addition to conducting key data analyses (e.g., receiver operating characteristic analysis, confidence accuracy characteristic analysis), statistical comparisons, signal-detection-based model fits, simulated data generation, and power analyses are also possible. We describe the package implementation and provide detailed instructions and tutorials with datasets so that users can follow. There is also an online manual that is regularly updated. We developed pyWitness to be user-friendly, reduce human interaction with pre-processing and processing of data and model fits, and produce publication-ready plots. All pyWitness features align with open science practices, such that the algorithms, fits, and methods are reproducible and documented. While pyWitness is a python toolkit, it can also be used from R for users more accustomed to this environment.
MHD 3D Mixed Upper Convective Flow of Maxwell Nanofluid Flow Past in the Presence of Diffusion Thermo and Thermophoresis Effect using Nonlinear Radiative Heat Flux
Authors: Gangadhar Goddubarla  , SharathBabu Kanday Rao  , Srinivasa Kumar Vajha  , Haribabu Kommaddi
Published: August 2023

This article aims to investigate the impact of nanoparticles and magnetohydrodynamics (MHD) on the transfer of heat and mass using a three-dimensional upper-convected Maxwell (UCM) nanofluid flow across a stretched surface. A nonlinear radiative heat flow was included in formulating the equation that describes energy. The nonlinear partial differential equations of the issue are transformed into ordinary differential equations utilizing the similarity transformation. These equations are then solved using the well-known shooting approach in conjunction with the Runge-Kutta integration process of order four. To increase the dependability of our findings, make use of the MATLAB. On the velocities, temperatures, and concentrations of the particles, the graphical and numerical representations of the effects of the main parameters, such as the Dufour parameter, the Brownian motion parameter, the Prandtl number, the thermophoresis parameter, and the magnetic parameter, are presented. It has been shown that the flow velocity decreases as a function of both the linear and nonlinear thermal radiation parameters. In addition, increasing values of the Brownian motion parameter have the effect of reducing the nanoparticle concentration profile
Phloretin Ameliorates Succinate-Induced Liver Fibrosis by Regulating Hepatic Stellate Cells
Authors: Le Cong Thuc , Nguyen Giang , Park So Young , Dong Hanh Nguyen , Cho Yun Kyung , Lee Jae-Ho , Im Seung-Soon , Choi Dae-Hee , Cho Eun-Hee
Published: August 2023

Background: Hepatic stellate cells (HSCs) are the major cells which play a pivotal role in liver fibrosis. During injury, extracellular stimulators can induce HSCs transdifferentiated into active form. Phloretin showed its ability to protect the liver from injury, so in this research we would like to investigate the effect of phloretin on succinate-induced HSCs activation in vitro and liver fibrosis in vivo study.Methods: In in vitro, succinate was used to induce HSCs activation, and then the effect of phloretin on activated HSCs was examined. In in vivo, succinate was used to generated liver fibrosis in mouse and phloretin co-treated to check its protection on the liver.Results: Phloretin can reduce the increase of fibrogenic markers and inhibits the proliferation, migration, and contraction caused by succinate in in vitro experiments. Moreover, an upregulation of proteins associated with aerobic glycolysis occurred during the activation of HSCs, which was attenuated by phloretin treatment. In in vivo experiments, intraperitoneal injection of phloretin decreased expression of fibrotic and glycolytic markers in the livers of mice with sodium succinate diet-induced liver fibrosis. These results suggest that aerobic glycolysis plays critical role in activation of HSCs and succinate can induce liver fibrosis in mice, whereas phloretin has therapeutic potential for treating hepatic fibrosis.Conclusion: Intraperitoneal injection of phloretin attenuated succinate-induced hepatic fibrosis and alleviates the succinate-induced HSCs activation.
Analysis of the Level of Compliance of Corporate Taxpayers in Reporting PPN Period SPT Using E-Invoice 3.0 on Tax Revenue Performance at KPP Pratama Manado
Authors: ELEM Sutri , KALANGI Lintje , KOROMPIS Claudia W.M.
Published: August 2023

Taxpayer compliance plays an important role in tax revenue. The more taxpayers are obedient in paying taxes, the greater the tax revenue received. The development of information systems and technology in the taxation sector continues to be carried out by the government to ensure compliance and accountability in tax collection. One of them is a change in the tax administration system or what is commonly called tax system modernization. In order to improve the ease of service to PKP, the Directorate General of Taxes released the latest e-invoice application, namely e-invoice 3.0. The e-faktur 3.0 application has a variety of the latest automation features which certainly make it easier for PKP to submit Periodic VAT Returns in only one application, namely e-faktur 3.0. This study aims to determine the level of compliance of corporate taxpayers in reporting Periodic VAT Returns using e-invoice 3.0 on the performance of tax revenue at KPP Pratama Manado. The method used in this research is a qualitative research method with a descriptive approach, the data source used is primary data. The results showed that the level of compliance of corporate taxpayers in reporting Periodic VAT returns using e-invoice 3.0 on the performance of tax revenue at KPP Pratama Manado with a percentage of effective and very effective revenue realization because it can be seen from the realization of tax revenue that has increased from period to period and from year to year.
Teaching Experiences with Overcrowded Classrooms in Primary Schools in the Or Tambo Coastal District of South Africa
Authors: Tshangana Noluthabo , Nomtshongwana Thanduxolo Albert , Buka Andrea Mqondiso
Published: August 2023

The focus of this paper was to explore teaching experiences with overcrowded classrooms in primary schools in OR Tambo Coastal District of South Africa. The paper took on a subjective exploration approach in which a contextual investigation configuration was embraced. Unstructured interviews were used to gather data. The paper’s overall findings indicate that teachers’ experiences with overcrowding in their classrooms are “stressful.” The overcrowding of a classroom has been identified as a stressful environment by teachers themselves. Inadequate classroom space, health and safety concerns, a lack of learner-teacher interaction, and disruptive behaviour were some of these conditions. Inadequate teaching time, an increase in workload, and emotional and psychological issues were also experienced by teachers. The research also reveals the factors that contribute to stressful experiences namely, Discipline, limited space, and insufficient resources. Additionally, the findings demonstrated that teachers use individual resources and collaborate with one another to manage classroom overcrowding. The paper recommends that the Department of Basic Education (DBE) builds more classrooms and puts in measures to ensure that the ratio of teachers is always below 1:30 in order for teachers to teach students without the stress of facing overload. This article adds to the existing literature on employee welfare in the South African educational system. Keywords: Overcrowded Classroom, Primary Teachers’ Experience, Classroom Discipline, Classroom Management Techniques.
Primula medogensis, a new species of Primulaceae from Tibet of China
Authors: Ju Wen-Bin , Deng Heng-Ning , Liu Feng , He Xing-Jin , Gao Xin-Fen , Xu Bo
Published: August 2023

We present a description of a newly discovered species, Primula medogensis, found in southern Xizang, China. Additionally, we explore distinctive morphological characteristics that aid in its taxonomy. The new species belongs to sect. Cordifoliae and exhibits morphological similarities to P. baileyana and P. rotundifolia. However, it can be distinguished by its densely grayish-haired roots, petioles that are 3–7 times longer than the leaf blades, a short stock surrounded by straight and withered petioles, reniform leaf blades with revolute margins, scapes shorter than or equal to leave and both at flowering and in fruiting, flowers solitary on the scapes.
Repair of a Tractional Retinal Detachment in the Setting of an Idiopathic Vasoproliferative Tumor
Authors: Adeghate Jennifer O. , Goldburg Samantha R. , Marr Brian , Sheyman Alan , Winokur Jules , Kaden Talia R.
Published: August 2023

Vasoproliferative tumors (VPT) are benign retinal lesions that may cause epiretinal membrane proliferation and tractional retinal detachments (TRD). We describe a case of a 71-year-old woman who presented with a macula involving TRD in the setting of a VPT. Given the limited number of publications on the management of these cases, we aim to articulate some principles we believe may be helpful in planning a surgical approach that maximizes postoperative anatomic and functional outcomes. We hope that our video provides useful guidance in preparing the vitreoretinal surgeon for managing this uncommon entity.

[
Ophthalmic Surg Lasers Imaging Retina
2023;54:485–488.]
Time-Resolved 3D cardiopulmonary MRI reconstruction using spatial transformer network
Authors: Zou Qing , Miller Zachary , Dzelebdzic Sanja , Abadeer Maher , Johnson Kevin M. , Hussain Tarique
Published: August 2023

The accurate visualization and assessment of the complex cardiac and pulmonary structures in 3D is critical for the diagnosis and treatment of cardiovascular and respiratory disorders. Conventional 3D cardiac magnetic resonance imaging (MRI) techniques suffer from long acquisition times, motion artifacts, and limited spatiotemporal resolution. This study proposes a novel time-resolved 3D cardiopulmonary MRI reconstruction method based on spatial transformer networks (STNs) to reconstruct the 3D cardiopulmonary MRI acquired using 3D center-out radial ultra-short echo time (UTE) sequences. The proposed reconstruction method employed an STN-based deep learning framework, which used a combination of data-processing, grid generator, and sampler. The reconstructed 3D images were compared against the start-of-the-art time-resolved reconstruction method. The results showed that the proposed time-resolved 3D cardiopulmonary MRI reconstruction using STNs offers a robust and efficient approach to obtain high-quality images. This method effectively overcomes the limitations of conventional 3D cardiac MRI techniques and has the potential to improve the diagnosis and treatment planning of cardiopulmonary disorders.
Fire and flood occurrence in the habitats of the endangered butterfly Coenonympha oedippus in Slovenia
Authors: Zupan Sara , Bužan Elena , Čelik Tatjana , Kovačič Gregor , Jugovic Jure , Lužnik Martina
Published: August 2023

In Slovenia the False ringlet Coenonympha oedippus uniquely occurs both on wet (Ljubljana Marsh and surroundings) and dry grasslands (Slovenian Istria, Karst, Gorica Hills). Natural hazards that threaten its habitats include fires and floods; the frequency of their occurrence in the former and existing habitats of C. oedippus was determined using the χ2-test. We showed that habitats on wet grasslands are less threatened by fire than those on dry grasslands. Among the latter, habitats in the Karst and Slovenian Istria are the most threatened. Habitats of C. oedippus are threatened by flooding only in Slovenian Istria and Ljubljana Marsh. Considering the extent of fire and flood risk and fragmentation of C. oedippus habitats in Slovenia, we assume that such natural hazards may lead to local extinction of the species.
National geniuses’ heritage as potential for the development of cultural tourism in Romania
Authors: Nicolaie Daniela , Matei Elena , Cooley Timothy John , Vijulie Iuliana , Cushing David , Truțescu Marius Nicolae
Published: August 2023

This article investigates how domestic tourists perceive the possibilities of boosting cultural heritage tourism in Romania, through the capitalization of national genius personalities. The methodology is based on the survey method. The research identified 22 geniuses, largely represented in national culture, and acknowledged and demanded by the market. The vast majority have been converted into tourist attractions, however those of international visibility are missing or are underrepresented in Romanian heritage tourism. An increased focus on geniuses would be highly valued by tourists and could reinforce the value of cultural heritage, consequently, boosting tourism resources. This would lead to multiple and sustainable benefits for destinations’ development, but certain infrastructure and management gaps would need to be filled.
Peuplements paléolithiques et paléoenvironnements pléistocènes dans le Massif central
Authors: Vernet Gérard , Angevin Raphaël
Published: August 2023

Au cours des dernières décennies, le déploiement des opérations préventives relatives à la Préhistoire ancienne en Auvergne a permis de mettre au jour de nombreux sites dont la contribution s’avère complémentaire de celle des gisements historiques. Leur mise en réseau modifie la connaissance de l’occupation paléolithique du Massif central, longtemps envisagée sous le prisme déformant du déterminisme climatique. La reconstitution des paléoenvironnements pléistocènes et la calibration des principaux événements volcaniques ont en outre conduit à réviser les paramètres en jeu dans les relations sociétés-milieux au sein d’un espace considéré comme contraint. D’un point de vue opérationnel, cette approche croisée et la prise en compte des potentiels de conservation régionaux posent un cadre d’intervention raisonné, articulant étroitement stratégies de prescription, de diagnostic et de fouille, tout en faisant varier la focale du site vers le territoire. Il en résulte une programmation originale de la recherche, visant à documenter au plus près les contextes dans lesquels les vestiges s’inscrivent et justifiant certains choix d’intervention à caractère prospectif sur des potentiels géoarchéologiques forts.
Vieille-Toulouse, métropole des Volques Tectosages
Authors: Gardes Philippe
Published: August 2023

Après vingt ans d’interruption, les recherches à Vieille-Toulouse ont repris à partir des années 2000. Une vingtaine de diagnostics et de fouilles ont été conduits dans le cadre des nouvelles lois sur l’archéologie préventive. Les résultats sont d’intérêt majeur. Ils concernent l’emprise du site, avec en particulier la mise en évidence d’une enceinte enserrant un espace de 190 à 200 hectares. À l’intérieur, le centre urbain de la Planho a pu être mieux défini. Il associe des monuments publics et un habitat dense, évoluant à un rythme rapide entre les années 175 et 10 avant notre ère. Les quartiers périphériques abritent quant à eux un habitat plus aéré et des ateliers d’artisans (tuiliers, potiers…). Un projet collectif de recherche (PCR) en cours permettra de synthétiser l’ensemble de ces recherches et aboutira à une publication monographique à l’horizon 2023.
L’avancée récente de l’étude des réseaux routiers anciens de la région Bretagne (1995-2020)
Authors: Leroux Gilles , Lorho Thierry
Published: August 2023

Il y a dix ans, le SRA Bretagne a lancé un inventaire du réseau viaire principal de la péninsule armoricaine afin d’enregistrer les vestiges et les tracés restitués dans Patriarche sous forme d’entités archéologiques afin, notamment, de proposer une réflexion sur le réseau viaire ancien et son évolution de la protohistoire au Moyen Âge et de susciter des actions d’étude, de protection et de valorisation. Les auteurs présentent leur retour sur expérience et un bref bilan.
Vingt ans de prescription et d’archéologie préventive à Paris
Authors: Chaoui-Derieux Dorothée
Published: August 2023

À Paris, l’évolution de l’exercice de prescription, en lien avec les politiques d’aménagement de la ville, et la multiplication des opérations d’archéologie préventive menées depuis vingt ans ont permis de renouveler les connaissances acquises sur la topographie urbaine, mais aussi d’interroger plus finement certaines problématiques, en lien notamment avec les questions de paléoenvironnement et de paléotopographie. Dans un espace fortement contraint, où les surfaces accessibles sont de plus en plus réduites, les opérations de diagnostic et de fouille doivent souvent faire face à des conditions de mise en œuvre complexes. La compilation des données acquises sur le terrain (notamment les épaisseurs de dépôts anthropiques) et l’élaboration d’une carte archéologique de plus en plus précise permettent aujourd’hui une meilleure évaluation du potentiel archéologique, utile à des fins de recherche, mais aussi d’aménagement.
Recherches sur l’histoire de Troyes, des origines à la fin du Moyen Âge
Authors: Kasprzyk Michel , Roms Cédric
Published: August 2023

Augustobona chef-lieu de la cité des Tricasses, puis la ville de Troyes se sont développées en aval de la confluence de la Seine et de la Vienne, un de ses modestes affluents en rive gauche, à l’endroit où le fleuve quitte les terrains argileux de la Champagne humide pour les terrains crayeux de la Champagne sèche. De nombreuses sources historiques et archéologiques montrent que les cours actuels des bras de la Seine et de la Vienne ont considérablement fluctué depuis la fin de la Protohistoire, tant par migration naturelle que sous l’effet de travaux de canalisation ou de dérivation. Dans un premier temps (1981-2020), l’activité archéologique préventive paraît conditionnée par l’historiographie ancienne de la ville de Troyes, qui considère le site urbain dans le seul cadre de l’enceinte de la fin du Moyen Âge. Dans un second temps (2001-2020), la multiplication des prescriptions sur l’ensemble du territoire communal semble refléter une prise en compte de l’espace périurbain comme une composante de la ville de la fin de l’âge du Fer, puis des périodes romaine et médiévale, tout comme le fait que ce territoire a connu une occupation antérieure (Préhistoire, Âge des métaux) à laquelle ne se superpose pas forcément la ville romaine et médiévale.
Ensilage expérimental en Roussillon. Approche croisée de l’archéologie et de la biologie
Authors: Dominguez Cécile , Yebdri Eric
Published: August 2023

L’expérimentation menée depuis 2016 dans l’unité Inrae à Alénya (Pyrénées-Orientales) par une équipe pluridisciplinaire a pour but de comprendre la technique d’ensilage autrement qu’au travers de l’analyse des fosses-silos abandonnées. La mise en place du protocole expérimental nous a conduits à mettre au cœur de nos préoccupations les qualités sanitaires, alimentaires et germinatives des stocks de grains expérimentaux. C’est l’expertise croisée d’agriculteurs céréaliers et de professionnels du stockage qui aide l’équipe d’archéologues à comprendre les résultats de l’ensilage expérimental. Les données anciennes et récentes en archéologie, en histoire et en ethnographie donnent quant à elles des pistes sur les différentes mises en œuvre et solutions techniques. L’objectif à terme est de produire des résultats et une méthodologie à destination des chercheurs (archéologues, historiens, agronomes) et éventuellement des solutions de stockage alternatives pour les producteurs et les transformateurs de céréales.
La détection des sites de la Préhistoire ancienne en Hauts-de-France
Authors: Goval Émilie , Locht Jean-Luc
Published: August 2023

La détection des sites du Paléolithique en archéologie préventive est sûrement l’un des enjeux méthodologiques récurrents de ces trente dernières années. La mise au jour des gisements de Seclin et de Biache-Saint-Vaast ont marqué l’histoire de la discipline en démontrant la possibilité d’allier détection, fouilles et recherche. Depuis, de nombreuses évolutions et ajustements méthodologiques ont émergé concernant le repérage des sites de la Préhistoire ancienne (Paléolithique inférieur, moyen et supérieur). Le partage d’expérience et le transfert de compétences à d’autres régions ont peu à peu permis une évolution significative des méthodes de diagnostic au niveau national. Les services déconcentrés de l’État jouent un rôle important dans le repérage des sites. Comment les prescriptions des SRA influencent-elles la recherche des sites paléolithiques ? Sans être exhaustive, cette réflexion permet de dresser un bilan d’étape de la détection des sites de la Préhistoire aux niveaux régional et national et les perspectives envisagées.
La photogrammétrie sur le site de Pontcharaud (Puy-de-Dôme)
Authors: Prodéo Frédéric , Deberge Yann
Published: August 2023

Le site de Clermont-Ferrand « Pontacharaud » a été densément occupé à maintes reprises pendant les six derniers millénaires avant notre ère. Tous les techniciens de fouille ont été formés pour que les structures soient relevées par photogrammétrie. Pour les sépultures en particulier, cette manière de procéder fournit les documents nécessaires aux anthropologues pour noter leurs observations lors du démontage des squelettes. Les modèles obtenus se prêtent à divers développements : métrologie, présentations multimédias, impression 3D. Les vases déposés en offrande dans les tombes néolithiques ont également été modélisés par photogrammétrie, permettant des rendus fidèles, utilisés pour la production de planches normalisées illustrant les rapports et les publications.
Acquisition numérique des données archéo-anthropologiques et spatiales. Le projet « Nécropole numérique »
Authors: Seng Christelle , Le Forestier Cyrille , El-Hajaoui Rachid
Published: August 2023

Ce projet de R & D a pour objectif la mise au point et l’expérimentation d’outils numériques dédiés à l’enregistrement des données de terrain en contexte funéraire. Sa particularité repose sur la dématérialisation intégrale de l’acquisition des données archéologiques, en s’appuyant sur la géomatique pour gérer les données spatiales et attributaires à partir de relevés issus de la photogrammétrie. La saisie et l’interrogation des données archéologiques s’effectuent par l’interface de QGIS dans une base de données archéologiques au format SQLite. Les sépultures sont modélisées et géoréférencées, puis l’édition d’une ortho-image, importée dans QGIS, permet de numériser les vestiges et de mettre instantanément en lien la géométrie et les données attributaires. Ce travail de terrain est ensuite complété et enrichi par les analyses effectuées en laboratoire, notamment les données anthropologiques. L’intégralité des données spatiales et attributaires est ainsi contenue au sein d’un projet unique, éditable et consultable dans QGIS. Les outils du logiciel permettent une grande diversité de représentations cartographiques et d’analyse spatiale des données.
L’« équipement » nécessaire au fonctionnement d’une villa. La villa de Saint-Clément (Yonne)
Authors: Fort Bérangère , Tisserand Nicolas , Chevrier Sébastien
Published: August 2023

Dans le comblement d’une cave du bâtiment de la pars urbana, mêlé à des gravats, a été découvert un lot composé de près de 200 objets métalliques, en sus de la clouterie. La cause de la destruction du bâtiment dans le courant de la première moitié du IIIe siècle de notre ère semble être un incendie. L’effondrement rapide d’une partie du bâtiment a scellé bon nombre d’éléments dans la cave (céramique, enduits peints, objets métalliques). La découverte d’un lot de mobilier homogène constituant un ensemble clos illustrant les activités d’un tel établissement à un instant T demeure exceptionnelle.
La collaboration suivie entre le musée de la Romanité et l’Inrap
Authors: Darde Dominique
Published: August 2023

À Nîmes, les liens entre le musée et les archéologues se sont tissés depuis les années 1950-60, le conservateur du musée archéologique s’étant vu confier la mission de correspondant de la Direction Régionale des Antiquités Historiques, pour tout le département du Gard. Dans les deux décennies suivantes, l’équipe du musée a activement participé aux premières opérations d’archéologie de sauvetage menées notamment par l’Association pour les fouilles archéologiques nationales (Afan). Cette collaboration s’est poursuivie avec les équipes de l’Inrap et c’est sur la base des informations qu’elles nous fournissent qu’ont pu être élaborées nos actions vers nos publics (expositions permanente et temporaires, conférences, écrans tactiles, tablettes numériques, audiovisuels, multimedia, réalité augmentée).
Comparison of Hybrid Artificial Neural Networks With GA, PSO, and RSA in Predicting COVID-19 Cases
Authors: Manohar Balakrishnama , Das Raja
Published: August 2023

The objective of the current study is to choose the best model with the highest accuracy rate using three robust hybrid artificial intelligence-based models: the ANN-GA, ANN-PSO and ANN-RSA. To do so, a sample of COVID-19 confirmed cases in India between August 1, 2021, and July 26, 2022, is first compiled. A random allocation of 70% (30%) of the total observation has been chosen as training (testing) data. After that, the LM method is used to train an ANN model. Accordingly, the appropriate number of hidden neurons is determined to be 9 using the R^2 and RMSE criterion. To achieve the highest accuracy rate, ANN-GA, ANN-PSO, and ANN-RSA models are developed using the presented ANN model. The optimized model's R-values during the training and test phases, according to ANN-GA and ANN-PSO, are 0.99 and 0.95, respectively. The R-values for ANN-RSA varied from 0.99 to 0.96. hence, the ANN-RSA demonstrated superior performance in forecasting COVID-19 cases in India.
Clinical and Experimental Evidence of Cirrhosis-Related Parkinsonism
Authors: El Hiba Omar , El-Mansoury Bilal , Chatoui Hicham , Benammi Hind , Balzano Tiziano , Merzouki Mohamed , Abdelmonaim El Hidan My , Radhakrishnan Jayakumar , Bahi Lahoucine , Idrissi Hamid Rguibi , Saadaoui Nabila , Tilaoui Mounir , Outeiro Tiago Fleming , Norenberg Michael D.
Published: August 2023

The clinical significance of hepatic encephalopathy (HE) includes a variety of neuropsychiatric abnormalities arising from both chronic and acute hepatic failures. Cirrhotic patients manifest symptoms related to acquired hepatolenticular degeneration (parkinsonism in cirrhosis); the disease is characterized by extrapyramidal symptoms including hypokinesia, dystonia, and rigidity that are rapidly progressive and independent of the severity of cognitive dysfunction, while imaging techniques revealed T1-weighted hyperintense signals in the globus pallidus (GP) and substantia nigra (SN) along with manganese (Mn) deposition leading to the dysfunction of the dopaminergic, glutamatergic, as well as GABAergic neurotransmitter systems in the basal ganglia. Through the chapter, the authors emphasize the common neurological and cognitive features between Parkinson's disease/parkinsonism and HE with a special focus on the underlying pathophysiological mechanisms.
Parkinson's Disease
Authors: Echchakery Mohamed , Guennouni Morad , Amane Mounia , Omari Mohammad , El Baz Soraia , Achbani Abderrahmane , Draoui Ahmed , Abdelmohcine Aimrane , El Otmani Ihsane , Rokni Taoufik , Elmoumou Lahcen , Hanchi Asmae Lamrani
Published: August 2023

Parkinson's disease is a progressive neurodegenerative disease characterized by the deterioration and death of a type of brain cell (neurons) in the brain and the accumulation of protein clumps that are toxic to nerve cells. These cells produce the molecule dopamine, involved in the coordination and generation of muscle movements. It affects millions of people around the world and causes permanent damage. It is a progressive disease in which the symptoms can degenerate. Thanks to the progress made in recent years, the pathophysiological processes at work are better understood. Ultimately, these discoveries should lead to the development of treatments capable of stopping or slowing the progression of the disease. But for the time being, the management of patients is mainly based on the administration of dopamine, in order to compensate for the effects linked to neurodegeneration and those of other drugs, which make it possible to relieve the non-motor symptoms of the disease.
Pesticide Exposure as a Risk Factor for Parkinson's Disease
Authors: Saad Fatima Ez-Zahraa , Lelo Aaron Pambu , Smimih Kamal , El-Mansoury Bilal , lkhanouchi Manal , El Amine Souad , Bitar Abdelali
Published: August 2023

Pesticides are very unique environmental pollutants that are introduced into the environment specifically to fight pests, frequently by killing them, and to protect cultures against losses and vector-transmitted diseases. Many studies have found potential toxic effects of pesticides on many organisms such as humans. Neurotoxicity has been found to be associated with the use of certain classes of pesticides, including insecticides, herbicides, and fungicides. Observational research has shown an association between some pesticide exposure, such as Rotenone, Paraquat, Organochlorines, Organophosphates, Pyrethroids, and Triazines, and the etiology of Parkinson's disease. In this chapter, the authors discuss the mechanisms of action of different pesticides involved in the pathology of PD.
Effects of Physical Activity on Pakinson's Disease Patients
Authors: Smimih Kamal , El-Mansoury Bilal , Laadraoui Jawad , Saad Fatima Ez-Zahraa , Merzouki Mohamed , Ammouta Lhoussaine , Khanouchi Manal , Aimrane Abdelmohcine , Azzouhri Chaima , Zouhairi Nadia , El Khiat Abdelaati , Bitar Abdelali , Ferssiwi Abdesslam
Published: August 2023

Parkinson's disease (PD) is the most common movement disorder worldwide, of which neuroprotective or neurorestorative therapy is not yet available. The current line treatments are believed to be effective in alleviating PD symptoms, but as the disease progress, various complications appear, and the treatment becomes challenging. Hence, the role of nonpharmacologic therapies in the treatment of PD is of great interest and can be useful to delay and slow the disease progression. Increasing evidence shows the important role of physical activity (PA) in the management and even the prevention of the disease. Several mechanisms are thought to explain the beneficial effect of exercise in PD. However, the exact neurobiological mechanisms underpinning this benefit are not fully understood. This chapter will discuss the benefit of exercise in PD patients and the possible molecular mechanisms by which PA could lead to these beneficial effects.
Potential Role of Probiotics and Fecal Microbiota Transplantation in the Treatment of Parkinson's Disease
Authors: El-Mansoury Bilal , Smimih Kamal , El Khiat Abdelaati , El Fatimi Hanane , Aimrane Abdelmohcine , El Baz Soraia , Elmourid Abdessamad , Saad Fatima Ez-Zahraa , El Ghachi Hafida , Khanouchi Manal , Jayakumar Arumugam Radhakrishnan , Zoubadi Abdeljalil
Published: August 2023

Parkinson disease (PD) is the second most common neurodegenerative disease worldwide. It is characterized by both motor and non-motor symptoms. The histopathological hallmark of PD is the loss of dopaminergic neurons from the substantia nigra combined with Lewy bodies (LBs) and Lewy neurites, together termed Lewy pathology. However, the exact pathophysiological mechanism underpinning PD remains undetermined. Compelling evidence highlights the potential involvement of gut microbiota dysbiosis in the pathogenesis of PD and point toward potential pathological mechanisms between the gastrointestinal tract and the brain. In this regard, microbiota-targeted interventions such as probiotics and fecal microbiota transplantation (FMT) have been recently demonstrated to have a beneficial role in alleviating PD symptoms and providing neuroprotection. This chapter briefly provides an overview of current knowledge on disturbed gut microbiota and the gut-brain axis in PD, followed by possible therapeutic interventions, with a particular focus on the use of probiotics and FMT.
Machine Learning Application for Evidence Image Enhancement
Authors: Sampangirama Reddy B. R.  , Saxena Ashendra Kumar , Pandey Binay Kumar , Gupta Sachin , Gurpur Shashikala , Dari Sukhvinder Singh , Dhabliya Dharmesh
Published: August 2023

Taking into account the uses of ML in the field of vision, many practical vision systems' first processing stages include enhancing or reconstructing images. The goal of these tools is to enhance the quality of photos and give accurate data for making decisions based on appearance. In this research study, the authors examine three distinct types of neural networks: convolutional networks, residual networks, and generative countermeasure networks. There is a proposal for a model structure of a scalable supplementary generation network as part of a network that enhances evidence images as a generative countermeasure. The authors present the objective loss function definition, as well as the periodic consistency loss and the periodic perceptual consistency loss analysis. An in-depth solution framework for picture layering is offered once the problem's core aspects are explained. This approach implements multitasking with the help of adaptive feature learning, this provides a strong theoretical guarantee.
An Empirical Study on the Impact of Social Media Promotion of Branded Drugs on the Health Behavior of Indian Patients
Authors: Mukherjee Samrat Kumar , Sarkar Abhijit , Mukherjee Subhadeep , Kumar Jitendra , Jha Ajeya
Published: August 2023

Branded drug social media promotion (SMP) has increased dramatically in the recent era. The impact of this new phenomenon (although it is illegal in most countries) on patient behaviour has not been thoroughly studied. The purpose of this research is to learn about patients' perceptions of the impact of SMP on their behaviour. The sample size is 380 people. Pearson correlation and regression were used for analysis. The study clearly shows that SMP has an effect on patients' negative behaviour as well as the patient-physician relationship. The government and physicians should be conscious that proper guidelines are needed to guide patients. In addition, patients must understand that physicians and their expertise are critical to their treatment.
On the Use of ICT by Enterprises to Activate Industrial Heritage
Authors: Ni Zebo , Ouyang Taohua
Published: August 2023

Despite the increasing use of information and communications technology (ICT) by enterprises engaged in industrial heritage, the academic community lacks sufficient understanding of how ICT enables the sustainable development of industrial heritage. This article fills this gap by analyzing the application of ICT by Taoxichuan Ceramic Art Avenue (the Company) to promote its organizational innovation and achieve the sustainable development of industrial heritage. To start with, the authors conceptualized the two stages, adaptive change, and breakthrough change, of ICT-induced organizational changes in industrial heritage. Secondly, they extended the research of affordance from the technical field to the social theory field and proposed the concept of organizational affordance. Finally, the authors provided suggestions for future research to employ organizational affordance to deepen our understanding of relevant fields.
Intervenção pedagógica nos esportivos coletivos: uma revisão sistemática
Authors: Mazzardo Tatiane , Aburachid Layla Maria Campos , Morales Juan Carlos Perez , Greco Pablo Juan
Published: August 2023

Analisou-se a produção da literatura com programas de intervenção, aplicados aos esportes coletivos. As bases de dados consultadas quanto ao tema, nos últimos 20 anos, foram o Web of Science, Scielo e PubMed. Utilizou-se as diretrizes PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) com as palavras-chave: jogo coletivo e jogos esportivos coletivos, associados aos termos: modelos de ensino, ensino do esporte, ensino-aprendizagem-treinamento, intervenção pedagógica, desempenho tático-técnico e processos cognitivos, nos idiomas português, inglês e espanhol. Após triagem com critérios definidos, 39 manuscritos foram selecionados para compor a amostra. A análise descritiva apontou que os anos de 2016 e 2018 apresentou maior quantitativo de publicações (17,95% cada ano); a língua inglesa a mais utilizada nas publicações (69,24%); as modalidades futebol e basquetebol compreenderam o maior número de trabalhos (25,64% e 17,95%, respectivamente); os programas de ensino abrangeram entre 5 e 54 sessões de aula; a amostra dos estudos com escolares foi a mais eleita (64,1%); a maioria dos programas de ensino centrou-se na tática; e as principais variáveis analisadas foram conhecimentos táticos, desempenho tático-técnico e habilidades específicas. Na produção de literatura analisada observou-se uma tendência nos últimos 10 anos à aplicação de programas de ensino dos esportes com abordagens táticas e ainda alterar e/ou agregar conteúdos a esses modelos, com o intuito de potencializar o desenvolvimento de alunos/atletas. Essas mudanças deixam abertas as reflexões sobre possíveis alterações de orientação docente na práxis no ensino-aprendizagem dos esportes coletivos.
Modeling the influence of basketball game parameters on the final result in Tokyo 2020
Authors: Simovic Slobodan , Komić Jasmin Komić , Pajic Zoran , Rađević Nenad , Guzina Bojan , Grahovac Goran
Published: August 2023

This study aims to ascertain the significance of the basketball game parameters which discriminated between winning and losing teams in matches played. The study sample comprises matches played at the men’s basketball tournament at the XXXII Olympic Games in Tokyo. Four regression models were formed. Due to the size of the sample, the number of explaining variables was reduced using factor analysis, followed by stepwise regression to ascertain the statistical significance of the obtained models summarily, which were then broken down into individual parameters. This study indicates: (1) one of the four set regression models was summarily highly statistically significant; (2) out of the remaining models, two were eliminated due to the presence of multicollinearity, and one model did not exhibit high statistical significance; (3) the final score was most influenced by the variables of two- and three-point shot percentages, number of three-point shots, turnovers, defensive rebounds, and true shooting percentage. The results of the study corroborated the results of other studies which were carried out in recent years, that the game of basketball is trending towards three-point shots and lay-ups, reduction of turnovers when passing, and defensive rebounds have been confirmed to be greatly significant.
O conhecimento do treinador esportivo no contexto de projetos sociais
Authors: Simarelli Paula , Galatti Larissa Rafaela , De Andrade Rodrigues Heitor , Silva Reverdito Riller , Rodrigues Paes Roberto
Published: August 2023

O Brasil possui inúmeros projetos sociais que visam garantir o direito ao esporte àqueles que vivem em situações de vulnerabilidade social. O objetivo deste artigo foi identificar os conhecimentos para a prática profissional em projetos sociais, a partir das percepções dos próprios treinadores. Entrevistas foram conduzidas com seis treinadores do maior programa social brasileiro, o Programa Segundo Tempo. Conhecer o esporte trabalhado e seus alunos foram os resultados mais expressivos. Ainda, conhecer questões pedagógicas e contextuais apresentam-se como necessárias. Entendemos esse estudo como um importante passo à promoção de discussões contextualizadas sobre esses treinadores, que convivem com situações de risco e possuem significativo papel social e formativo em nossa sociedade.
Fatores associados à dinapenia em idosos do nordeste brasileiro
Authors: Santos Lucas dos , Silva Rizia Rocha , Santana Pabline dos Santos , Valença Neto Paulo da Fonseca , Almeida Cláudio Bispo de , Casotti Cezar Augusto
Published: August 2023

Este estudo identificou os fatores associados à dinapenia em idosos residentes em um município de pequeno porte do Nordeste brasileiro. Trata-se de um estudo populacional, conduzido com 208 idosos (58,7% mulheres) de Aiquara-BA. As informações sociodemográficas, comportamentais e de condições de saúde foram obtidas em entrevistas face a face, e o estado nutricional foi avaliado pelo índice de massa corporal. Para mensuração do nível de atividade física e do comportamento sedentário, utilizou-se o International Physical Activity Questionnaire. O diagnóstico da dinapenia foi realizado por sexo, a partir do percentil 25 da força de preensão manual, averiguada com um dinamômetro hidráulico. Para análises inferenciais foi utilizada a regressão de Poisson, com estimador robusto, cálculo das Razões de Prevalência (RP) e de seus respectivos intervalos de confiança de 95% (IC). A prevalência de dinapenia foi maior nos idosos com idade entre 70-79 (RP: 3,21; IC95%: 1,55-6,64) e ≥80 anos (RP: 4,91; IC95%: 2,32-10,39), nos com baixo peso (RP: 2,20; IC95%: 1,26-3,82), nos insuficientemente ativos (RP: 1,99; IC95%: 1,12-3,54) e entre os com elevado comportamento sedentário (RP: 1,88; IC95%: 1,19-2,98). Identificou-se que os fatores associados à dinapenia foram: idade entre 70-79 e ≥80 anos, nível de atividade física insuficiente; elevado comportamento sedentário e baixo peso.
Qualidade de vida de professores de educação física universitários: uma análise de clusters
Authors: Araldi Franciane Maria , Martins Alessandra Catarina , Dantas da Mota Íris , Both Jorge , Coutinho de Azevedo Guimarães Adriana , Oliveira Farias Gelcemar , Folle Alexandra
Published: August 2023

A docência no Ensino Superior exige o envolvimento em diversas funções que podem afetar a percepção de qualidade de vida desta classe de trabalhadores. O estudo buscou determinar os perfis de qualidade de vida de professores de Educação Física do Ensino Superior e associá-los às suas características pessoais e profissionais. Participaram 93 professores da mesorregião da Grande Florianópolis. Utilizou-se um questionário de caracterização e o Whoqol-bref e empregou-se análise de Clusters, método Ward e testes Kruskal Wallis, Friedman e Qui-Quadrado. Identificou-se três grupos de professores: Grupo I apresentou percepção mais negativa e escores menores em todo constructo da qualidade de vida (sem vínculos com a extensão); Grupo II revelou percepção mais positiva e escores mais elevados da qualidade de vida (coordenadores de ações extensionistas); Grupo III apresentou percepção regular da avaliação geral e dos domínios físico e psicológico e escores intermediários quando comparados aos demais Grupos (colaboradores da extensão universitária).
Polimorfismo do gene ACTN3 e os fatores associados ao desempenho funcional de idosas atendidas na atenção primária em saúde
Authors: Machado Leandro César Teixeira , Medeiros Mateus , Stival Marina Morato , De Sousa Barbalho Yuri Gustavo , De Lima Filipe Dinato , De Lima Luciano Ramos , Silva Alessandro de Oliveira , Da Silva Izabel Cristina Rodrigues , Funghetto Silvana Schwerz
Published: August 2023

Objetivo: analisar as potenciais influências do polimorfismo genético R/X do gene ACTN3 e das características antropométricas e metabólicas no desempenho funcional de mulheres idosas atendidas na atenção primária em saúde. Método: Cento e quarenta e uma idosas foram avaliadas em relação as características antropométricas, metabólicas, funcionais, aspectos clínicos, cognitivos e demográficos. Foram determinadas as frequências de alelos e genótipos do polimorfismo do gene ACTN3. Resultados: 141 idosas (68,30 ± 6,18 anos) foram avaliadas. Não foram observadas diferenças significativas (p > 0,05) entre os genótipos RR e RX/XX no desempenho funcional, características antropométricas ou metabólicas das idosas. O tempo de realização do TUG apresentou correlações positivas com idade, índice de massa corporal, circunferência da cintura e percentual de gordura (s = 0,315; p < 0,001; s = 0,238; p = 0,005; s = 0,174; p = 0,039; s = 0,207; p = 0,014) respectivamente. Correlações negativas foram observadas entre o TUG com força de preensão manual absoluta (s = - 0,314; p < 0,001) e relativa (s = - 0,380; p < 0,001). Conclusão: Em nosso estudo, não foram observadas influências dos polimorfismos do gene ACTN3 no desempenho funcional das idosas, sendo este, influenciado por outros fatores.
Itinerários de combate da Federação Paraense de Luta Marajoara
Authors: Afonso Ferreira dos Santos Carlos , Alan Gonçalves Andrade Welison , Gonçalves de Freitas Rogério
Published: August 2023

O objetivo deste artigo foi analisar os primeiros passos da recém-criada Federação Paraense de Luta Marajoara (FPLM), e compreender quais os possíveis impactos de sua governança na escolarização e esportivização desta luta. Nesta pesquisa, de cunho qualitativo, a técnica utilizada para a reunião dos dados foi a entrevista não diretiva. Os participantes da pesquisa foram dois membros da FPLM. Constatou-se que a FPLM como instituição autoreguladora estrutura suas propostas de escolarização e esportivização em um contexto de governança esportiva centralizada, estabelecendo-se como detentora de um monopólio sobre a Luta Marajoara ao idealizar intenções voltadas ao impulsionamento local e regional dessa luta brasileira. Contudo, a pesquisa conclui que o longo caminho de “combate” da FPLM se dará entre sua concepção prática autoreguladora em contraste ao sentido crítico e democrático para o reconhecimento da Luta Marajoara.