bluuebunny/crossref_metadata_2025 huggingface dataset:
Roughness of Production Conditions: Does It Really Affect Stability of IgG-Based Antivenoms?
Authors: Mateljak Lukačević Sanja , Kurtović Tihana , Borić Juraj , Halassy Beata
Published: July 2022

Antivenoms contain either pure animal IgGs or their fragments as an active substance, and are the only specific therapeutics against envenomation arising from snakebites. Although they are highly needed, the low sustainability of such preparations’ manufacture causes constant global shortages. One reason for this is the stability of the product, which contributes not only to the manufacture sustainability, but the product safety as well. It has been hypothesized that the roughness of conditions to which IgGs are exposed during downstream purification disturbs their conformation, making them prone to aggregation, particularly after exposure to secondary stress. The aim of this research was to investigate how the roughness of the downstream purification conditions influences the stability properties of purified IgGs. For this purpose, equine IgGs were extracted from unique hyperimmune plasma by two mild condition-based operational procedures (anion-exchange chromatography and caprylic acid precipitation) and three rougher ones (ammonium sulphate precipitation, cation-exchange chromatography and protein A affinity chromatography). The stability of the refined preparations was studied under non-optimal storage conditions (37 °C, 42 °C, and a transiently lower pH) by monitoring changes in the aggregate content and thermal stability of the pure IgGs. Mild purification protocols generated IgG samples with a lower aggregate share in comparison to the rougher ones. Their tendency for further aggregation was significantly associated with the initial aggregate share. The thermal stability of IgG molecules and the aggregate content in refined samples were inversely correlated. Since the initial proportion of aggregates in the samples was influenced by the operating conditions, we have shown a strong indication that each of them also indirectly affected the stability of the final preparations. This suggests that mild condition-based refinement protocols indeed generate more stable IgGs.
Relations of Public Transport Use and Car Ownership with Neighbourhood and City-Level Travel Purposes in Kerman, Iran
Authors: Masoumi Houshmand , Chakamera Chengete , Mapamba Liberty , Pisa Noleen , Soltanzadeh Hamid
Published: July 2022

There are significant deviations in travel mode choice drivers between developed and developing countries. This study investigates the determinants of car ownership and public transit ridership in Iran. Using survey data from 800 respondents, the determinants of travel behaviour of Kerman residents were investigated, based on gender, age, household size, car ownership, frequency of public transport ridership, number of working days per week, number of shopping activities in the neighbourhood per week, number of entertainment activities in the neighbourhood per week, and number of shopping activities in the city. Two multivariate models were estimated using the OLS and WLS methods. Our findings suggested that owning a car tends to increase as age, household size, number of working days and number of shopping days in the city decreases. An increase in the number of entertainment days in the neighbourhood raised the probability of car ownership while shopping in the neighbourhood did not influence car ownership. Public transport use was negatively influenced by gender, increased age and number of working days, but positively influenced by shopping in the city. Our research results have significant implications for transport planning. Firstly, changes in household size may not be a good basis to inform planning as our findings show that in Kerman as household size increases, car ownership decreases, and it does not influence public transport. Secondly, when planning road network connectivity (land use) higher working days are expected to increase both car ownership and public transport use.
Self-Repairing Herpesvirus Saimiri Deletion Variants
Authors: Heyn Ines , Bremer Linda , Zingler Philipp , Fickenscher Helmut
Published: July 2022

Herpesvirus saimiri (HVS) is discussed as a possible vector in gene therapy. In order to create a self-repairing HVS vector, the F plasmid vector moiety of the bacterial artificial chromosome (BAC) was transposed via Red recombination into the virus genes ORF22 or ORF29b, both important for virus replication. Repetitive sequences were additionally inserted, allowing the removal of the F-derived sequences from the viral DNA genome upon reconstitution in permissive epithelial cells. Moreover, these self-repair-enabled BACs were used to generate deletion variants of the transforming strain C488 in order to minimalize the virus genome. Using the en passant mutagenesis with two subsequent homologous recombination steps, the BAC was seamlessly manipulated. To ensure the replication capacity in permissive monkey cells, replication kinetics for all generated virus variants were documented. HVS variants with increased insert capacity reached the self-repair within two to three passages in permissive epithelial cells. The seamless deletion of ORFs 3/21, 12–14, 16 or 71 did not abolish replication competence. Apoptosis induction did not seem to be altered in human T cells transformed with deletion variants lacking ORF16 or ORF71. These virus variants form an important step towards creating a potential minimal virus vector for gene therapy, for example, in human T cells.
Virus Hijacks Host Proteins and Machinery for Assembly and Budding, with HIV-1 as an Example
Authors: Lin Chih-Yen , Urbina Aspiro , Wang Wen-Hung , Thitithanyanont Arunee , Wang Sheng-Fan
Published: July 2022

Viral assembly and budding are the final steps and key determinants of the virus life cycle and are regulated by virus–host interaction. Several viruses are known to use their late assembly (L) domains to hijack host machinery and cellular adaptors to be used for the requirement of virus replication. The L domains are highly conserved short sequences whose mutation or deletion may lead to the accumulation of immature virions at the plasma membrane. The L domains were firstly identified within retroviral Gag polyprotein and later detected in structural proteins of many other enveloped RNA viruses. Here, we used HIV-1 as an example to describe how the HIV-1 virus hijacks ESCRT membrane fission machinery to facilitate virion assembly and release. We also introduce galectin-3, a chimera type of the galectin family that is up-regulated by HIV-1 during infection and further used to promote HIV-1 assembly and budding via the stabilization of Alix–Gag interaction. It is worth further dissecting the details and finetuning the regulatory mechanism, as well as identifying novel candidates involved in this final step of replication cycle.
SARS-CoV-2 Genomic Characteristics and Clinical Impact of SARS-CoV-2 Viral Diversity in Critically Ill COVID-19 Patients: A Prospective Multicenter Cohort Study
Authors: Fourati Slim , Audureau Etienne , Arrestier Romain , Marot Stéphane , Dubois Claire , Voiriot Guillaume , Luyt Charles-Edouard , Urbina Tomas , Mayaux Julien , Roque-Afonso Anne-Marie , Pham Tài , Landraud Luce , Visseaux Benoit , Roux Damien , Bellaiche Raphael , L’honneur Anne-Sophie , Ait Hamou Zakaria , Brichler Ségolène , Gaudry Stéphane , Salmona Maud , Clere-Jehl Raphaël , Azoulay Elie , Morand-Joubert Laurence , Marcelin Anne-Geneviève , Chaix Marie-Laure , Descamps Diane , Mekontso Dessap Armand , Rodriguez Christophe , Pawlotsky Jean-Michel , de Prost Nicolas
Published: July 2022

The SARS-CoV-2 variant of concern, α, spread worldwide at the beginning of 2021. It was suggested that this variant was associated with a higher risk of mortality than other variants. We aimed to characterize the genetic diversity of SARS-CoV-2 variants isolated from patients with severe COVID-19 and unravel the relationships between specific viral mutations/mutational patterns and clinical outcomes. This is a prospective multicenter observational cohort study. Patients aged ≥18 years admitted to 11 intensive care units (ICUs) in hospitals in the Greater Paris area for SARS-CoV-2 infection and acute respiratory failure between 1 October 2020 and 30 May 2021 were included. The primary clinical endpoint was day-28 mortality. Full-length SARS-CoV-2 genomes were sequenced by means of next-generation sequencing (Illumina COVIDSeq). In total, 413 patients were included, 183 (44.3%) were infected with pre-existing variants, 197 (47.7%) were infected with variant α, and 33 (8.0%) were infected with other variants. The patients infected with pre-existing variants were significantly older (64.9 ± 11.9 vs. 60.5 ± 11.8 years; p = 0.0005) and had more frequent COPD (11.5% vs. 4.1%; p = 0.009) and higher SOFA scores (4 [3–8] vs. 3 [2–4]; 0.0002). The day-28 mortality was no different between the patients infected with pre-existing, α, or other variants (31.1% vs. 26.2% vs. 30.3%; p = 0.550). There was no association between day-28 mortality and specific variants or the presence of specific mutations. At ICU admission, the patients infected with pre-existing variants had a different clinical presentation from those infected with variant α, but mortality did not differ between these groups. There was no association between specific variants or SARS-CoV-2 genome mutational pattern and day-28 mortality.
Conversion of Industrial Sludge into Activated Biochar for Effective Cationic Dye Removal: Characterization and Adsorption Properties Assessment
Authors: Jellali Salah , Azzaz Ahmed Amine , Al-Harrasi Majida , Charabi Yassine , Al-Sabahi Jamal Nasser , Al-Raeesi Ahmed , Usman Muhammad , Al Nasiri Noura , Al-Abri Mohammed , Jeguirim Mejdi
Published: July 2022

This paper presents an in-depth characterization of a raw industrial sludge (IS-R) and its KOH-activated biochar pyrolyzed at 750 °C (IS-KOH-B) followed by their application to remove a cationic dye from aqueous solution. Materials characterization shows that compared to the IS-R, the IS-KOH-B has improved structural, textural, and surface chemical properties. In particular, the IS-KOH-B’s BET surface area and total pore volume are about 78 and 6 times higher than those found for the IS-R, respectively. The activated biochar efficiently retained the cationic dye under wide experimental conditions. Indeed, for an initial dye concentration of 50 mg L−1, removal yields were assessed to be more than 92.5%, 93.5%, and 97.8% for a large pH range (4–10), in the presence of high contents of competing cations (3000 mg L−1 of Ca2+, Mg2+, Na+, and K+), and a low used adsorbent dose (1 g L−1), respectively. The Langmuir’s adsorption capacities were 48.5 and 65.9 mg g−1 for of IS-R and IS-KOH-B, respectively, which are higher than those reported for various adsorbents in the literature. The dye removal was found to be monolayer, spontaneous, and endothermic for both the adsorbents. Moreover, this removal process seems to be controlled by chemical reactions for IS-KOH-B whereas by both physico–chemical reactions for IS-R. This study demonstrates that the raw industrial sludge and especially its KOH-activated derived biochar could be considered as promising adsorbents for the removal of dyes from aqueous solutions.
Development of an Objective Low Flow Identification Method Using Breakpoint Analysis
Authors: Raczyński Krzysztof , Dyer Jamie
Published: July 2022

Low flow events (a.k.a. streamflow drought) are described as episodes where stream flows are lower or equal to a specified minimum threshold level. This threshold is usually predefined at the methodological stage of a study and is generally applied as a chosen flow percentile, determined from a flow duration curve (FDC). Unfortunately, many available methods for choosing both the percentile and FDCs result in a large range of potential thresholds, which reduces the ability to statistically compare the results from the different methods while also losing the natural character of the phenomenon. The aim of this work is to introduce a new approach for low flow threshold calculation through the application of an objective approach using breakpoint analysis. This method allows for the identification of an environmental moment of river transition, from atmospheric feed flows to base flow, which characterizes the moment at the beginning of the hydrological drought. The method allows for not only the capture of the genesis of a low flow event but, above all, unifies the approach toward threshold levels and completely excludes the impact of the subjective researcher’s decisions, which occur at the methodological stage when selecting the threshold criteria or when choosing a respective percentile. In addition, the method can be successfully used in datasets characterized by a high level of discretization, such as numerical model data, where the subsurface runoff component is not described in sufficient detail. Results of this work show that the objective identification method is better able to capture the occurrence of a low flow event, improving the ability to identify hydrologic drought conditions. The proposed method is published together with the Python module objective_thresholds for broad use in other studies.
Correction: Gasperi et al. Micropollutants in Urban Runoff from Traffic Areas: Target and Non-Target Screening on Four Contrasted Sites. Water 2022, 14, 394
Authors: Gasperi Johnny , Le Roux Julien , Deshayes Steven , Ayrault Sophie , Bordier Louise , Boudahmane Lila , Budzinski Hélène , Caupos Emilie , Caubrière Nadège , Flanagan Kelsey , Guillon Martin , Huynh Nina , Labadie Pierre , Meffray Laurent , Neveu Pascale , Partibane Chandirane , Paupardin Julien , Saad Mohamed , Varnede Lucie , Gromaire Marie-Christine
Published: July 2022

In the original publication [...]
Genetic Diversity, Antimicrobial Resistance and Survival upon Manure Storage of Campylobacter jejuni Isolated from Dairy Cattle Farms in the Cantabric Coast of Spain
Authors: Varsaki Athanasia , Ortiz Sagrario , Santorum Patricia , López Pilar , López-Alonso Victoria , Martínez-Suárez Joaquín V.
Published: July 2022

The aim of this study was the examination of the genetic diversity and antimicrobial susceptibility of C. jejuni isolates obtained from dairy farms situated in Cantabria. The presence of Campylobacter jejuni was scrutinized in dairy farms situated in the Cantabria region (Atlantic coast, North of Spain). A total of 520 samples were collected from 12 dairy farms and 62 C. jejuni isolates were achieved. Sixty-one (61) of the isolates proceeded from fresh feces and only one from the stable (soil). Characterization of the isolates was conducted by Pulsed Field Gel Electrophoresis (PFGE) analysis. Antimicrobial susceptibility testing was carried out by standardized disk diffusion test. The PFGE analysis showed a high genetic diversity. From the 62 C. jejuni isolates, 27 different PFGE types were obtained with 70% similarity. The results of the antimicrobial susceptibility tests showed that 21 out of 27 strains were resistant to ciprofloxacin (78%), and 15 of them were also resistant to tetracycline (55%), whereas none of the 27 strains analyzed were resistant to erythromycin. C. jejuni was capable of surviving in livestock waste for at least 20–25 days, whereas the maximum detectable survival time on crops was of six days. This study reveals the high genetic diversity and ciprofloxacin resistance of C. jejuni in dairy cattle farms in Northern Spain, a fact that highlights the urgent need for the surveillance and control of this foodborne pathogen.
The Effect of Using Whatsapp on EFL Students' Medical English Vocabulary Learning During the Covid-19 Pandemic
Authors: Alenezi Saud , Bensalem Elias
Published: July 2022

The role of social networking mobile applications such as WhatsApp in enhancing second language vocabulary learning among English language learners continues to be a subject of interest for many scholars. The current study aimed at examining medical English vocabulary learning among undergraduate students using WhatsApp compared to learning vocabulary via Blackboard platform during the Covid-19 pandemic. To this end, 108 medical students (51 males, 57 females) enrolled in a first semester English for a specific English course participated in the study. A quasi-experimental design was adopted for two groups. Fifty-three students were assigned to the WhatsApp group and 55 students were assigned to the Blackboard group. Data were collected using pretest-posttest design. Results of t-test scores revealed no significant difference between the WhatsApp and Blackboard groups on a vocabulary test. Results of survey that gauged students' perception of the use of WhatsApp as a platform for learning new vocabulary showed positive perceptions since participants thought that WhatsApp enhanced their learning experience.
Survei Kesadaran Memelihara Lingkungan Hidup Berdasarkan Perspektif Ekoteologi di STT Simpson Ungaran
Authors: Budiman Sabda , Objantoro Enggar
Published: July 2022

Tindakan memelihara lingkungan hidup secara intensif dan berkelanjutan menjadi hal utama yang perlu dilakukan. Pemeliharaan lingkungan hidup juga tidak terlepas dari peran serta orang Kristen, terkhusus mahasiswa teologi selaku calon pemimpin di gereja dan masyarakat. Oleh karena itu, mahasiswa di Sekolah Tinggi Teologi (STT) Simpson Ungaran juga perlu memiliki kesadaran yang baik dalam hal memelihara lingkungan hidup. Tujuan penulisan dalam penelitian ini yaitu: “Untuk mengetahui tingkat kesadaran mahasiswa dalam memelihara lingkungan hidup berdasarkan perspektif ekoteologi di STT Simpson Ungaran.” Metode yang penulis gunakan dalam penelitian ini ialah metode penelitian kuantitatif dengan pendekatan survei. Berdasarkan hasil penelitian dan analisis data yang penulis lakukan, terlihat bahwa kesadaran mahasiswa memelihara lingkungan hidup berdasarkan perspektif ekoteologi di STT Simpson Ungaran dikategorikan baik dengan persentase 88,79%.  Kesadaran mahasiswa memelihara lingkungan hidup yang baik juga terlihat dari kesadaran dalam aspek pemahaman yang memperoleh persentase 91,50% dengan kategori sangat baik, kesadaran dalam aspek pemanfaatan yang memperoleh persentase 87,80% dengan kategori baik, dan kesadaran dalam aspek pelestarian yang memperoleh persentase 90,21% dengan kategori baik.
Inhibition of Cancer Cell Migration and Glycolysis by Terahertz Wave Modulation via Altered Chromatin Accessibility
Authors: Sun Lan , Li Yangmei , Yu Yun , Wang Peiliang , Zhu Shengquan , Wu Kaijie , Liu Yan , Wang Ruixing , Min Li , Chang Chao
Published: July 2022

Metastasis and metabolic disorders contribute to most cancer deaths and are potential drug targets in cancer treatment. However, corresponding drugs inevitably induce myeloid suppression and gastrointestinal toxicity. Here, we report a nonpharmaceutical and noninvasive electromagnetic intervention technique that exhibited long-term inhibition of cancer cells. Firstly, we revealed that optical radiation at the specific wavelength of 3.6 
μ
m (i.e., 83 THz) significantly increased binding affinity between DNA and histone via molecular dynamics simulations, providing a theoretical possibility for THz modulation- (THM-) based cancer cell intervention. Subsequent cell functional assays demonstrated that low-power 3.6 
μ
m THz wave could successfully inhibit cancer cell migration by 50% and reduce glycolysis by 60%. Then, mRNA sequencing and assays for transposase-accessible chromatin using sequencing (ATAC-seq) indicated that low-power THM at 3.6 
μ
m suppressed the genes associated with glycolysis and migration by reducing the chromatin accessibility of certain gene loci. Furthermore, THM at 3.6 
μ
m on HCT-116 cancer cells reduced the liver metastasis by 60% in a metastatic xenograft mouse model by splenic injection, successfully validated the inhibition of cancer cell migration by THM
in vivo
. Together, this work provides a new paradigm for electromagnetic irradiation-induced epigenetic changes and represents a theoretical basis for possible innovative therapeutic applications of THM as the future of cancer treatments.
Confronto, judicialização e burocracia
Authors: Spinieli André Luiz Pereira
Published: July 2022

Este artigo objetiva discutir a crítica bolsonarista ao presidencialismo de coalizão como estratégia para a manutenção de um modelo institucional denominado "presidencialismo de confrontação". Esse paradigma tem como base a utilização das instâncias judiciais como instrumentos para fazer avançar projetos políticos não aprovados na dinâmica congressual, além da eleição de adversários e inimigos públicos. Para isso, buscamos avançar teoricamente sobre as formas pelas quais o presidencialismo de coalizão tem se expressado na política brasileira e apresentar a ideia de confrontação no contexto do bolsonarismo. Esse modelo de presidencialismo garante a ausência de coalizões no mandato de Jair Bolsonaro? Recorremos à literatura especializada em ciência política sobre presidencialismo de coalizão, judicialização da política e análises sobre o fenômeno do bolsonarismo no país e suas repercussões nas esferas judicial e legislativa. Apesar da opção bolsonarista pelo paradigma de confrontação, concluímos que tem ocorrido coalizões naturais em seu governo, além da constante utilização do Judiciário como forma de legitimar demandas não aprovadas no Congresso Nacional.
Enhanced piezoelectric and dielectric properties of AC poled sliver-mode Pb(In1/2Nb1/2)O3-Pb(Mg1/3Nb2/3)O3-PbTiO3 single crystals for ultrasonic abdomen probes
Authors: Sun Yiqin , Ota Yuhei , Kim Hwang-Pill , Wang Zhuangkai , Fujii Tadashi , Yamashita Yohachi (John) , Karaki Tomoaki , Jiang Xiaoning
Published: July 2022

The effect of AC poling (ACP) on the piezoelectric and dielectric properties of diced sliver-mode vibrators (L13 × W0.15–0.30 × T0.51 mm3) was investigated for a convex abdomen ultrasound (US) probe that is made of a large Pb(In1/2Nb1/2)O3-Pb(Mg1/3Nb2/3)O3−0.3PbTiO3 (PIN-PMN-PT) single crystal (SC) plate (L13 × W60 × T0.51 mm3). The SC was manufactured by the continuous feeding Bridgman (CF-BM) method. The

ε

33

T

/ε
0 aging rate (AR) of both DCP and ACP large plate SCs were found to be within 1%/decade suggesting no obvious property degradation. After array dicing, a considerable decrease in electromechanical and dielectric properties was observed. After a post-dicing DCP, the diced DCP-DCP 0.15 mm wide SC slivers showed

ε

33

T

/ε
0 and electromechanical coupling factor (k′33) of 4300 and 89.1%, respectively. The diced ACP-DCP 0.15 mm wide SC slivers showed improved

ε

33

T

/ε
0 and k′33 of 5980 and 92.2%, respectively, which are considered useful in practical medical array transducer applications.
Desain Kerangka Baru Sistem Keamanan Sepeda Motor Berbasis EDR (Event Data Recorder)
Authors: Kusuma Bagus Adhi , Indartono Kuat , Jahir Abdul , Purwadi Purwadi , Ramadhani Arief Kurnia
Published: July 2022

Abstrak. Kendaraan bermotor adalah salah satu alat transportasi penting di Indonesia. Namun jumlah kecelakaan lalu-lintas kendaraan bermotor makin meningkat dari waktu ke waktu sehingga diperlukan suatu sistem yang dapat mengetahui kejadian riil pada saat terjadinya kecelakaan. Terkadang kecelakaan tunggal tanpa adanya saksi yang melihat kejadian tersebut dapat menimbulkan efek bahaya yang lebih parah bagi pengemudinya. Oleh karena itu, untuk meningkatkan faktor keselamatan bagi pengendara perlu dirancang suatu kerangka sistem terintegrasi yang dapat sekaligus berfungsi sebagai alat investigasi kecelakaan kendaraan bermotor. Pada penelitian ini kerangka dibangun dengan menggunakan sensor-sensor pendukung yang terekam dalam suatu data logger (EDR) yang berfungsi untuk menyimpan aktifitas selama periode tertentu. Investigasi kecelakaan dapat dapat terbantu dengan menggunakan kerangka ini, dan jumlah korban kecelakaan dapat diminimalisir dengan adanya emergency system yang terhubung dengan GPS dan aplikasi android. Invertigasi sangat berguna untuk memberikan rekomendasi penting terkait penyebab kecelakaan kepada dewan keselamatan transportasi di suatu negara, di Indonesia diatur oleh Komite Nasional Keselamatan Transportasi (KNKT). Penelitian ini melakukan pengembangan sistem melalui pendekatan baru dari penelitian-penelitian sebelumnya yang menghasilkan suatu kerangka baru yang dapat digunakan untuk penelitian selanjutnya. Kata kunci: Kerangka, Emergency System, Investigasi, Kecelakaan Lalu-lintas, Data Logger

Abstract. Motorized vehicles are one of the important means of transportation in Indonesia. However, the number of motor vehicle traffic accidents is increasing from time to time, so we need a system that can find out the real events at the time of the accident. Sometimes a single accident in the absence of witnesses to see the incident can have a more severe hazard effect on the driver. Therefore, to increase the safety factor for motorists, it is necessary to design an integrated system that can simultaneously function as a vehicle accident investigation tool. In this study, a framework was built using supporting sensors recorded in a data logger (EDR) that functions to store activity for a certain period. Accident investigations can be helped by using this framework, and the number of accident victims can be minimized with an emergency system connected to GPS and an Android application. Investigation is very useful to provide important recommendations regarding the causes of accidents to the transportation safety board in a country, in Indonesia it is regulated by Komite Nasional Keselamatan Transportasi (KNKT). This research conducts system development through a new approach from previous studies which produces a new framework that can be used for further research. Keywords: Framework, Emergency System, Investigation, Traffic Accident, Data Logger
Analisis Dan Perancangan Sistem Publikasi Realisasi Anggaran Desa
Authors: Dwiyanti I Gusti Ayu Aris , Eka Putra I Gede Juliana , Purnama I Nyoman
Published: July 2022

Information services for the implementation of the Village Fund Allocation from the village government to the community are still manual so that the information received by the community is still minimal. This article aims to analyze and design an information system model for the publication of village budget realization, so that the community can easily access information anywhere and anytime regarding the realization of the village budget in Keramas Gianyar Village. This study uses the software development life cycle (SDLC) method with a linear sequential model, where the tools used in designing the village budget realization publication system use Data Flow Diagrams (DFD), Databases using Entity Relational Database (ERD), Data Dictionary. The results of the System Usability Scale (SUS) test show that the average score is at a value of 77, indicating that the user interface of the village budget realization publication system in Keramas Village is at grade B with an Adjective Rating Good.

Keywords: Accounting Information System, Village Fund Allocation, Village Publication System

 

ABSTRAK. Layanan informasi pelaksanaan Alokasi Dana Desa dari pemerintah desa ke masyarakat masih manual sehingga informasi yang diterima masyarakat masih minim. Artikel ini bertujuan untuk menganalisis dan merancang model sistem informasi untuk publikasi realisasi anggaran desa, agar masyarakat dapat dengan mudah mengakses informasi dimana saja dan kapan saja mengenai realisasi anggaran desa di Desa Keramas Gianyar. Penelitian ini menggunakan metode software development life Cycle (SDLC) dengan model sekuensial linier, dimana tools yang digunakan dalam merancang sistem publikasi realisasi anggaran desa menggunakan Tools Data Flow Diagram (DFD), Basis Data yang menggunakan Entity Relational Database (ERD), Kamus Data. Hasil pengujian System Usability Scale (SUS) menunjukkan Skor rata-rata berada pada nilai 77, menunjukkan user interface sistem publikasi realisasi anggaran desa di Desa Keramas berada pada grade B dengan Adjective Rating Good.

Kata kunci: Sistem Informasi Akuntansi, Alokasi Dana Desa, Sistem Publikasi Desa
Sistem Informasi Pelayanan Data Pegawai Online Pada Badan Kepegawaian Pendidikan Dan Pelatihan Kabupaten Barito Kuala
Authors: Husin Muhammad Fahriza Amir , Ruliah Ruliah , Fadilah Fadilah
Published: July 2022

Abstrak. Sistem Informasi Manajemen Kepegawaian (SIMPEG) Badan Kepegawaian dan Pelatihan Pendidikan Kabupaten Barito Kuala sudah menggunakan komputer sebagai alat bantu kerja dalam pengolahan administrasi kepegawaian, akan tetapi masih berbasis Desktop (stand Alone), sehingga proses pembaruan data pegawai, pengajuan cuti atau kenaikan pangkat menjadi tidak efektif karena pegawai harus datang langsung ke kantor badan kepegawaian. Paper ini menyajikan model Sistem Informasi Manajemen Kepegawaian (SIMPEG) berbasis Online sehingga proses usulan kenaikan pangkat, update data pegawai dan usulan cuti dengan mudah dapat dilakukan kapan saja dan dimana saja. Pengembangan sistem mengikuti tahapan dalam model pengembangan Waterfall. Hasil pengujian User Acceptance menyimpulkan bahwa sistem yang dibangun menghasilkan sistem pelayanan kepegawaian yang lebih baik, sehingga pegawai yang ingin melakukan pembaruan data, pengajuan cuti dan pengajuan kenaikan kepangkatan dapat dilakukan secara online kapan saja dan dimana saja.

Kata kunci: Sistem Informasi, Administrasi Kepegawaian, Online

Abstract. Personnel Management Information System (SIMPEG) the Educational Training and Personnel Agency of Barito Kuala Regency already uses computers as work aids in processing personnel administration, but it is still desktop-based (stand alone), so that the process of updating employee data, submitting leave or promotion becomes ineffective because employees have to come directly to the office of the personnel agency. This paper presents an Online-based Personnel Management Information System (SIMPEG) model so that the process of promotion proposals, employee data updates and leave proposals can easily be done anytime and anywhere. System development follows the stages in the Waterfall development model. The results of the User Acceptance test concluded that the system built resulted in a better personnel service system, so that employees who wish to update data, submit leave applications and apply for promotions can be done online anytime and anywhere.

Keywords: Information System, Personnel Administration, Online
Implementasi Algoritma Certainty Factor Dalam Sistem Pakar Untuk Mendiagnosa Penyakit Kulit Pada Kucing
Authors: Romadiana Parlia , Septryanti Ade , Sari Lili Indah
Published: July 2022

Abstrak. Kesehatan pada hewan peliharaan khsusunya Kucing perlu diperhatikan agar terhindar dari berbagai jenis penyakit, seperti penyakit iritasi pada kulit Kucing. Tujuan dari penelitian ini membuat aplikasi Sistem Pakar yang dapat membantu orang awam melakukan penanganan awal penyakit kulit pada Kucing berdasarkan gejala yang ditemui. Sistem aplikasi mendiagnosa penyakit kulit pada Kucing dengan menggunakan algoritma Certainty Factor (CF). Terdapat 23 gejalan yang menjadi dasar penalaran pada algoritma CF untuk menentukan jenis penyakit kulit pada Kucing. Hasil uji terhadap 2 sampel penyakit pada Kucing menunjukkan aplikasi sistem pakar yang dikembangkan dapat digunakan untuk mendiagnosa penyakit Ring Worm dengan tingkat kepercayaan 87,20% dan penyakit Scabies dengan tingkat kepercayaan 90,78%.

Kata kunci: Penyakit kulit, Certainty Factor, Sistem Pakar, Kucing
Abstract. The health of pets, especially cats, needs to be considered in order to avoid various types of diseases, such as irritating diseases on the cat's skin. The purpose of this study is to create an Expert System application that can help ordinary people carry out initial treatment of skin diseases in cats based on the symptoms encountered. The application system diagnoses skin diseases in cats using the Certainty Factor (CF) algorithm. There are 23 symptoms that form the basis of reasoning in the CF algorithm to determine the type of skin disease in cats. The results of the test on 2 samples of disease in cats showed that the expert system application developed could be used to diagnose Ring Worm disease with a confidence level of 87.20% and Scabies disease with a confidence level of 90.78%.
Keywords: Skin disease, Certainty Factor, Expert System, Cats

 
Penentuan Jalur Terdekat Angkutan Kelapa Sawit Berbasis Algoritma Dijkstra
Authors: Taufiq Taufiq , Yudihartanti Yulia
Published: July 2022

Abstrak. Banyaknya jalur alternatif yang dapat dilalui oleh armada pengangkutan buah Kelapa Sawit dari suatu Blok Kebun Produksi ke Parik Pengolahan pada Perusahaan Perkebunan Kelapa Sawit PT. Pucuk Jaya, menyebabkan tidakefisiennya waktu tempuh pengangkutan jika keliru dalam menentukan Jalur terdekat. Artikel ini menyajikan model aplikasi penentuan jalur angkut terdekat bagi armada angkutan untuk mengangkut buah Kelapa Sawit dari blok Kebun produksi ke Pabrik Pengolahan. Metode penalaran yang digunakan dalam aplikasi adalah algoritma Dijkstra. Sepuluh Blok Kebun dengan berbagai jalur alternatif yang tersedia menuju ke Pabrik Pengolahan diujicoba dalam pengujian kinerja algoritma. Hasil pengujian kinerja algoritma menunjukkan 30% data jalur yang diuji mampu dinalar oleh algoritma sesuai dengan jalur rekomendasi terbaik yang disarankan oleh manajemen pabrik, sedangkan 70% data jalur lainnya mampu dinalar oleh algoritma secara lebih baik dari jalur rekomendasi terbaik yang disarankan oleh manajemen pabrik.

Kata Kunci: Penentuan Jalur Terdekat, Armada angkutan Kelapa Sawit, Algoritma Dijkstra

Abstract. The number of alternative routes that can be traversed by the oil palm fruit transportation fleet from a Production Plantation Block to a Processing Plant at the Oil Palm Plantation Company PT. Pucuk Jaya, causing inefficiency in transportation travel time if you make a mistake in determining the closest route. This article presents an application model for determining the closest transportation route for transportation fleets to transport oil palm fruit from the production plantation block to the processing factory. The reasoning method used in the application is Dijkstra's algorithm. Ten Farm Blocks with various alternative paths available to the Processing Plant were tested in algorithm performance testing. The results of the algorithm performance test show that 30% of the path data tested are able to be reasoned by the algorithm according to the best recommendation path suggested by the factory management, while 70% of the other path data are able to be reasoned by the algorithm better than the best recommendation path suggested by the factory management.

Keywords: Determination of the Nearest Path, Oil Palm Transportation Fleet, Dijkstra's Algorithm
Rancangan Sistem Informasi Aktivitas Produksi Batubara Pada Perusahaan Titan Group
Authors: Andiani Andiani , Fadhil M. Aiman
Published: July 2022

Abstrak. Penggunaan sistem aplikasi konvensional dalam pengolahan data, temu kembali data dan informasi, serta akses dan penyampaian informasi ke berbagai pihak yang terkait dengan manajemen perusahaan Batu Bara Titan Group menyebabkan proses menjadi tidak efisien. Paper ini menyajikan model Sistem Informasi berbasis Web untuk mengelola data aktivitas produksi Batubara pada Perusahaan TitanGroup. Pengembangan sistem aplikasi mengikuti tahapan umum dalam model SDLC (System Development Life Cycle). Desain sistem menggunakan teknik pemodelan berbasis Objek (Object Oriented Design/OOD) dengan Tools pemodelan UML (Unified Modeling Language), sedangkan konstruksi aplikasi menggunakan bahasa pemrograman PHP dan database MySql. Metode Focus Group Discussion dengan melibatkan perwakilan bagian-bagian dalam perusahaan, baik pada tingkat operasional maupun pada tingkat manajerial organisasi dalam menganalisis kebutuhan sistem. Hasil analisi kebutuhan menetapkan fitur-fitur fungsionalitas pada aplikasi berupa fitur untuk memperoses, temu kembali, dan menyajikan informasi coal getting, chauling, crushing, barging secara otomatis dan cepat, serta dapat melihat record setiap aktifitas penambangan dan stock batubara di masing masing area secara online.

Kata Kunci: Sistem Informasi, Aktivitas Produksi, Penambangan Batubara, Berbasis Web, Unified Modeling Language
Abstract. The use of conventional application systems in data processing, retrieval of data and information, as well as access and delivery of information to various parties related to the management of the Titan Group Coal Company causes the process to be inefficient. This paper presents a Web-based Information System model for managing data on coal production activities at TITAN Group Companies. Application system development follows the general stages in the SDLC (System Development Life Cycle) model. The system design uses Object Oriented Design (OOD) with UML (Unified Modeling Language) modeling tools, while the application construction uses the PHP programming language and MySql database. Focus Group Discussion method by involving representatives of parts within the company, both at the operational level and at the organizational managerial level in analyzing system requirements. The results of the needs analysis determine the functional features of the application in the form of features for processing, retrieval, and presenting information on coal getting, chauling, crushing, barging automatically and quickly, as well as being able to view records of every mining activity and coal stock in each area online.

Keywords: Information Systems, Production Activities, Coal Mining, Web-Based, Unified Modeling Language
Implementasi Metode Least Square Untuk Prediksi Penjualan Kue Donat dan Bomboloni
Authors: Octavia Ranti Wilda Nur , Chotijah Umi
Published: July 2022

Abstrak. Prediksi Jumlah permintaan kue donat dan bomboloni oleh pelanggan (konsumen) Toko Milly Donuts selama ini tidak akurat, dimana jumlah produksi tidak sesuai dengan jumlah permintaan konsumen.  Penelitian ini bertujuan mengimplementasikan Metode Least Square untuk melakukan forecast (prediksi) dalam penjualan. Metode Least Square merupakan salah satu teknik dalam menyusun forecast penjualan dengan meminimumkan fungsi kriteria jumlah kuadrat kesalahan prediksi serta menggunakan Mean Squad Error (MSE), Mean Absolute Deviation (MAD) dan Mean Absolute Percentage Error (MAPE) untuk mengetahui tingkat kesalahan dalam metode least square. Prediksi menggunakan metode Trend Least Square, dimana nilai peramalan yang didapatkan diharapkan sesuai data aktual. Data yang dipakai dalam penelitian ini merupakan pencatatan penjualan kue donat dan bomboloni pada bulan Januari 2021 hinggai bulan Desember 2021. Hasil penelitian memperoleh forecast penjualan untuk bulan Januari hingga Maret 2022 sebanyak 1550,1579,1608 dengan kesalahan sebesar 0,34 pada MAD, 1,707 pada MSE dan 0,03602% pada MAPE.

Kata kunci: Prediksi; Least Square; Mean Squad Error; Mean Absolute Deviation; Mean Absolute Percentage Error

 

Abstract. Prediction of requests amount for donuts and bomboloni by customers (consumers) of Milly Donuts Shop so far is not accurate, where the amount of production does not match the number of consumer requests. This study aims to implement the Least Square Method to forecast (prediction) in sales. The Least Square method is one of the techniques in preparing sales forecasts by minimizing the criterion function for the number of squares of prediction errors and using Mean Squad Error (MSE), Mean Absolute Deviation (MAD) and Mean Absolute Percentage Error (MAPE) to determine the error rate in the least squares method. Prediction using the Trend Least Square method, where the forecast value obtained is expected to match the actual data. The data used in this study is the recording of sales of donuts and bomboloni in January 2021 to December 2021. The results of the study obtained sales forecasts for January to March 2022 as many as 1550,1579,1608 with errors of 0.34 in MAD, 1.707 in MSE and 0.03602% on MAPE.

Keywords: Prediction; Least Square; Mean Squad Errors; Mean Absolute Deviation; Mean Absolute Percentage Error
Komparasi Algoritma Naïve Bayes, Logistic Regression Dan Support Vector Machine pada Klasifikasi File Application Package Kit Android Malware
Authors: Diana Diana , Indrajit Richardus Eko , Dazki Erick
Published: July 2022

Abstrak. Fenomena malware yang terus bertumbuh pada sistem Android menjadikan peneliti berfokus untuk menganalisa malware dengan memanfaatkan teknologi kecerdasan buatan. Tujuan dari penelitian ini adalah menganalisa file-file APK (Application Package Kit) Android dengan mengklasifikasi keluarga malware. File malware akan dijadikan dataset untuk dilakukan training menggunakan algoritma pembelajaran mesin. Pembelajaran mesin yang digunakan adalah Naïve Bayes, Logistic Regression dan Support Vector Machine. Pengukuran performansi dan akurasi juga disajikan dalam perbandingan antara algoritma Naïve bayes, Logistic Regression dan Support Vector Machine yang merupakan algoritma Machine Learning dan bagian dari kecerdasan buatan. Hasil uji akurasi menunjukkan algoritma Naive Bayes mampu mengklasifikasi keluarga malware dengan tingkat akurasi 97.75%, sedangkan algoritma Logistic Regression akurasinya 88.75% dan akurasi Support Vector Machine mencapai 96,75%. Meskipun akurasi tidak setinggi penelitian sebelumnya, teknik analisa statis dengan fitur Permission dan fitur Intent cukup sederhana untuk mendeteksi file APK Android adalah malware atau bukan malware.

Kata kunci: Malware Android; Naïve Bayes; Logistic Regression; Support Vector Machine

 
Abstract. The phenomenon of malware that continues to grow on the Android system makes researchers focus on analyzing malware by utilizing artificial intelligence technology. The purpose of this research is to analyze Android APK (Application Package Kit) files by classifying malware families. The malware files will be used as a dataset for training using machine learning algorithms. The machine learning used is Naïve Bayes, Logistic Regression and Support Vector Machine. Performance and accuracy measurements are also presented in a comparison between the Naïve Bayes algorithm, Logistic Regression and Support Vector Machine which is a Machine Learning algorithm and part of artificial intelligence. The accuracy test results show that the Naive Bayes algorithm is able to classify malware families with an accuracy rate of 97.75%, while the Logistic Regression algorithm has an accuracy of 88.75% and an accuracy of Support Vector Machine reaches 96.75%. Although the accuracy is not as high as previous studies, the static analysis technique with the Permission feature and the Intent feature is quite simple to detect Android APK files are malware or not malware.

Keyword: Malware Android; Naïve Bayes; Logistic Regression; Support Vector Machine
Model Sistem Informasi Geografis Berbasis Web Rute Terdekat Menuju Restoran di Kota Semarang Dengan Algoritma A*
Authors: Furqon Ilham Rizqi , Wismarini Theresia Dwiati
Published: July 2022

Abstrak. Untuk mempermudah wisatawan menemukan lokasi serta rute terdekat menuju lokasi wisata, diperlukan suatu teknologi untuk mendukung hal tersebut. Penelitian ini mengusulkan model sistem informasi geografis berbasis Web mobile untuk membantu wisatawan menemukan lokasi restoran yang ada di Kota Semarang. Sistem aplikasi didukung oleh Algoritma A* untuk menemukan rute terdekat menuju lokasi restoran yang dituju. Pemodelan sistem menggunakan tools pemodelan berorientasi objek, sedangkan pengembangan sistem menggunakan editor Visual Studio Code, bahasa pemrograman PHP, dan database MySql. Hasil analisis kebutuhan fungsional mengidentifikasi pitur utama aplikasi berupa pendataan restoran dan posisinya, menu khas restoran; proses pencarian lokasi pada map; informasi titik lokasi, rute jalan, serta analisis penyelesaian masalah rute terdekat. Uji Black Box menunjukkan fitur-fitur fungsional aplikasi telah dinyatakan valid sesuai kebutuhan pengguna. Uji pencarian rute terdekat juga memperlihatkan sistem berbasis Algoritma A* yang dikembangkan mampu menemukan rute terdekat yang lebih baik dari aplikasi Google Map.

Kata Kunci: Sistem Informasi Geografis; Rute terpendek; Algoritma A*; Berbasis Web Mobile

 

Abstract. To make it easier for tourists to find the nearest location and route to tourist sites, a technology is needed to support this. This study proposes a mobile Web-based geographic information system model to help tourists find the location of restaurants in Semarang City. The application system is supported by the A* Algorithm to find the closest route to the destination restaurant location. The system modeling uses object-oriented modeling tools, while the system development uses the Visual Studio Code editor, the PHP programming language, and the MySql database. The results of the functional requirements analysis identify the main features of the application in the form of data collection on restaurants and their positions, typical restaurant menus; the process of finding the location on the map; location point information, road routes, as well as analysis of solving problems of the nearest route. The Black Box test shows that the functional features of the application have been declared valid according to user needs. The test of finding the closest route also shows that the developed A* Algorithm-based system is able to find the closest route which is better than the Google Map application.

Keywords: Geographic Information System; The shortest route; Algorithm A*; Mobile Web Based
Rancangan Sistem Informasi Pelelangan Barang Berbasis Web Pada Kantor Pegadaian
Authors: Triyawan Muhamad Rizal , Ramadhan Muhammad Hamdan , Syahidin Yuda
Published: July 2022

Abstrak. Sistem pelelangan barang pada kantor Pegadaian XYZ yang masih diselenggaran secara manual (tatap muka langsung) menyebabkan proses menjadi tidak efektif. Tujuan penulisan ini adalah menyajikan rancangan sistem Informasi berbasis Web yang dapat digunakan untuk mendukung proses pelelangan barang pada Perusahaan Pegadaian. Sistem aplikasi dikembangkan menggunakan metode pengembangan Agile. Rancangan sistem menggunakan kombinasi tools perancangan secara terstruktur dan berorientasi objek. Sistem didesain untuk dapat mengintegrasikan pihak Administrator Lelang, pemilik Barang, dan calon pembeli. Beberapa fungsi yang diidentifikasi pada sistem berupa Pendaftaran peserta dan barang lelang, pendaftaran calon pembeli, informasi barang lelang, pengajuan penawaran, serta informasi barang lelang yang dimenangkan.  Hasil uji fungsional menggunakan BlackBox testing menunjukkan seluruh fungsi-fungsi yang terdapat dalam aplikasi telah sesuai dengan kebutuhan pengguna sistem.

Kata kunci: Sistem Informasi; Pelelangan Barang; Berbasis Web; Metode Agile

 

Abstrak. The goods auction system at the XYZ Pawnshop office which is still being held manually (face to face) causes the process to be ineffective. The purpose of this paper is to present a Web-based information system design that can be used to support the process of auctioning goods at the Pawnshop Company. The application system is developed using Agile development methods. The system design uses a combination of structured and object-oriented design tools. The system is designed to be able to integrate the Auction Administrator, Goods owner, and potential buyers. Some of the functions identified in the system are registration of participants and auction items, registration of prospective buyers, information on auction items, submission of bids, and information on auction items won. The results of the functional test using BlackBox testing show that all the functions contained in the application are in accordance with the needs of system users.

Keywords: Information System; Goods Auction; Web Based; Agile Method