bluuebunny/crossref_metadata_2025 huggingface dataset:
Electrochemical in vitro Properties of 316L Stainless Steel for Orthodontic Applications
Authors: Simionescu Nicoleta , Ravoiu Anca , Benea Lidia
Published: January 2020

316L Stainless steels are widely used in biomedical applications with respect to their excellent corrosion resistance, nonmagnetic properties, high ductility and acceptable biocompatibility. There have been made electrochemical studies in-vitro in order to determine the corrosion reactions, which are necessary for foreseeing the behavior of the materials used in orthodontic applications. The degradation of metals and alloys in the human body is a combination of effects due to corrosion and mechanical activities. In dentistry, 316L stainless steel are used in a variety of applications: sterilized instruments, endodontic files in root canal therapy, metal posts in root canal treated teeth, temporary crowns, arch wires and brackets in orthodontics, a necessary condition for these applications must to resist to pitting corrosion. The pitting corrosion can be observed only in the case of passivable steels and in the presence of halogen or sulphur ions, in saline or acidic media like the human body. this type of corrosion propagates under the form of small pits, which give off to a significant quantity of metal ions, being very dangerous to the body. The metal ions resulted from the corrosive processes have allergic, carcinogenic and cytotoxic effects. The aim of this work was to evaluate the corrosion behavior of 316L stainless steel immersed in two artificial saliva solutions. The electrochemical measurements such as: open Circuit Potential (OCP), linear Polarization Resistance (LRP), and electrochemical Impedance Spectroscopy (EIS), methods were used to fulfill the corrosion evaluation. The research work concludes that the increase of the pH with a higher concentration of chloride contents lead to a lowest corrosion resistance while a decrease of the pH with a lowest concentration of chlorides contents reveals a higher corrosion resistance.
Isolation and Characterization of Hederagenin from Hedera helix L. Extract with Antitumor Activity
Authors: Tatia Rodica , Zalaru Christina , Tarcomnicu Isabela , Moldovan Lucia , Craciunescu Oana , Calinescu Ioan
Published: January 2020

Hederagenin, a saponin known for its therapeutic effect was isolated from leaves of Hedera helix. Hederagenin was obtained by repeated maceration of ground plant material in 95% (v/v) ethanol. The ethanolic extract was subjected to acid hydrolysis and purification with acetonitrile. Isolated hederagenin (IHe) was analyzed by HPLC-MS/MS and compared to standard hederagenin. In vitro cytotoxicity of IHe was tested in a culture of fibroblast cells from NCTC clone L929 cell line by MTT assay, using dioscin as positive control. For the determination of IHe antitumor effect, in vitro tests were performed in a culture of human cervix carcinoma Hep-2 cells cultivated in the presence of different concentrations of sample for 48 h. IHe was biocompatible in the range of concentrations 2-200 mg/mL, in NCTC cell culture. The compound showed cell cytotoxicity in the concentration range of 100-400 mg/mL, in Hep-2 cell culture, revealing its antitumor activity. These results demonstrated the possible use of hederagenin isolated from H. helix extract as an antitumor agent.
Synthesis and Characterization of New Solketal Alkylesters Usable as Diesel Biobased Fuel Additives
Authors: Neamtu Constantin , Stepan Emil , Plesu Valentin , Bozga Grigore , Tuluc Alexandru
Published: January 2020

There are described experimental studies on the esterification of solketal, (the cyclic acetal produced from glycerol and acetone reaction), by transesterification reactions of the -OH group with methyl esters of C3 -C10aliphatic acids (propionic, pentanoic, hexanoic, octanoic and decanoic). The goal was to obtain better additives for diesel and biodiesel fuels, as compared to solketal. The measured physical properties (especially density, viscosity and water solubility) of the synthesized solketal esters, closer to the corresponding ones for the diesel and biodiesel fuels, permit to suppose that these new compounds should be better additives for diesel type fuels, as compared with solketal. For three of these esters there were studied the liquid-vapor equilibrium at different temperatures, determining also the Antoine equation coefficients for the calculation of vapor pressure.
Research on Soil Resources of the NorthWest Part of the Cracau-Bistrita Depresion for Sustainable Agriculture
Authors: Stanila Anca-Luiza , Simota Catalin Cristian , Dumitru Mihail , Dumitru Sorina Iustina , Ignat Petru
Published: January 2020

Cracau-Bistrita Depression it belongs to the investigated it is a unique physical geographical unit within Moldavian Subcarpatians, which occupies the center of the groove subcarpathic between Moldova and the Trotus Rivers. In geological terms we refer territory corresponds to a restricted part of the Moldavian Platform appears as an extension to the southwest of Russian platform. Geological rocks that are part of the northwest Cracau-Bistrita Depression parent materials generated relatively differentiated by features and nature that can be eluvial, colluvial and alluvial. After compiling size, they are made of clay and marly clay, sand, alluvial deposits. The main pedogenetic processes which led to differentiation and the formation horizons of soil the soil cover of the northwest Cracau-Bistrita Depression may be mentioned bioaccumulation, clay migration, argillisation, gleyzation and stagnogleyzation. Ensemble pedogenetic factors and pedogenetic processes specific area led to the formation of a coating on the ground floor consists of relatively varied protisols, cernisols, cambisols, luvisols, hidrisols and antrisols. Of these, the largest share is occupied by cernisols. Arable land suitability is limited by several factors, of which the most important are considered the soil, topography and drainage. So outstanding were six classes of land: from those with very good suitability for field crops, without restriction, to land that can be used only for forests as those from nearby watercourses due to flooding. Misuse of the land has led to extreme natural phenomena, considered risks that go to produce immense damage by reducing agricultural production. I particularly physical, chemical and complex risks. Most worthy of notice covers the main physical and chemical properties of soil and land degradation by destroying the soil. In order to eliminate the negative effects of limiting factors of agricultural production, reducing risk and thereby improving the productive potential of the northwest Cracau-Bistrita Depression were proposed a series of works agropedoameliorative such as regulation of water and embankment works, paper land on the contour and avoiding weeding plant cultivation on slopes, erosion control works and avoid prolonged grazing early spring or fall, ripping papers for land compacted or affected by excess moisture.
In vitro Evaluation of Static Frictional Forces at the Bracket-archwire Interface
Authors: Dragomirescu Anca-Oana , Rizescu Ciprian-Ion , Mihai Ana-Maria , Bencze Angelica , Teodorescu Elina , Pacurar Mariana , Ionescu Ecaterina
Published: January 2020

The aim of this research is to compare the static frictional forces generated by different bracket-archwire couples. The study group consisted of three types of ceramic brackets (polycrystalline alumina with stainless steel slot, polycrystalline alumina and monocrystalline alumina), one stainless steel bracket and two types of archwires (0.016` NiTi and 0.019x0.025` SS). Brackets corresponding to the upper right quadrant (form upper right central incisor to the upper right second premolar) were bonded on standardized maxillary models and elastomeric ligatures were used to secure the archwire to the bracket system. An in-vitro experiment was conducted using a testing machine designed to measure the compression and traction force, both in dry and wet testing conditions. The results indicated statistically significant differences between most bracket-archwire groups. According to the data obtained, stainless steel brackets produced the lowest static frictional forces, regardless of test conditions and orthodontic archwire type. Polycrystalline ceramic brackets with stainless steel slot generated higher static frictional forces than stainless steel brackets, but lower than ceramic brackets when combined with the 0.019`�0.025` SS archwire. No significant differences were found between polycrystalline and monocrystalline ceramic brackets. Experiments performed with 0.019�0.025` SS archwire produced greater static frictional forces than those with 0.016` NiTi wire. Static frictional forces were not significantly influenced by the test conditions.
PON-1, Possible Biomarker for Diagnosis But Also for Risk in Diastolic Dysfunction with Preserved Ejection Fraction
Authors: Coculescu Bogdan Ioan , Harsovescu Tudor , Tudorache Ioan Sorin , Manole Gheorghe
Published: January 2020

The determined values of paraoxonase-1 serum concentration in 91 patients with cardiac insufficiency with a preserved ejection fraction with etiology of ischemic cardiopathy showed that this as an antioxidant enzyme may be accepted as a diagnostic biomarker, the assessment of the response to therapy, but also risk in this condition. Reporting circulating values of isozyme to the sex of patients revealed a very good correlation for males, which would confer PON1 specificity of sex to such a condition.
Research Concerning the Use of Polynomial Functions in the Study of the Conventional Sucker Rod Pumping Units
Authors: Badoiu Dorin
Published: January 2020

The analysis of the conventional sucker rod pumping units and especially their dynamics is laborious and requires a large amount of calculations due to the constructive complexity of the component structural elements. Therefore, expressing in a simplified but sufficiently precise form the various cinematic and dynamic parameters that characterize the proper functioning of the pumping units is extremely useful in analyzing the possibilities of their functional optimization. In the paper are presented a series of results concerning the expressing of some cinematic and dynamic parameters using polynomial functions in the case of the mechanism of a C-640D-305-120 pumping unit. The simulations have been performed with a computer program developed by the author using Maple programming environment. Experimental records processing was performed with the program Total Well Management.
Fibroblast Growth Factor 23 and Cardiovascular Outcome in Acute Kidney Injury
Authors: Onofrei Simona Daniela , Radulescu Daniela , Peride Ileana , Niculae Andrei , Checherit Ionel Alexandru
Published: January 2020

Even though the identification of Fibroblast Growth Factor 23 (FGF23) has been the breakthrough of the last decades in understanding mineral homeostasis, it is clear that it could have only been the starting point of an outstanding biomarker. This article focuses on available literature data concerning the increase of FGF23 in AKI and its potential influence upon associated or future to be cardiovascular disease.
Formulation, Preparation , Physico-Chemical, Microbiological Analysis and Clinical Uses of Capsaicin Microemulsions
Authors: Tatu Alin Laurentiu , Elisei Alina Mihaela , Lificiu Oana , Diaconu Camelia , Miulescu Magdalena , Dumitriu Buzia Olimpia
Published: January 2020

The present paper aims at creating a pharmaceutical formulation, i.e. microemulsion with capsaicin as the active principle; the purpose was to solubilize capsaicin and draw up pseudoternary phase diagrams establishing the microemulsion domains. We created a pharmaceutical form: capsaicin ointment, aiming at releasing capsaicin in the microemulsion and ointment bases. Comparative microbiological determinations were performed between microemulsion and ointment. The novelty of the study is formulating microemulsions as a means of solving solubility issues and increasing the bioavailability of medicinal substances.
Advantages of Negative Pressure Therapy in Local Diabetic Foot Treatment
Authors: Tantu Monica Marilena , Man George Mihail , Paunescu Alina , Plesa Cristina Florentina , Nicolae Camelia , Rogozea Liliana Marcela , Bisoc Alina , Mostafa Marwa F. , Nemes Roxana Maria , Diaconu Magdalena
Published: January 2020

Diabetic foot is a current public health problem and a late consequence of diabetes. Morbidity and mortality are significant, seriously affecting the patient�s quality of life. Treatment of the diabetic foot is a long-lasting, highly resource-consumption process. Using negative pressure therapy leads to shorter hospitalization periods, better functional outcomes, significantly contributes to decreasing the number of amputations and improving patient�s quality of life. 49 year-old patient is hospitalized with necrotizing at right foot and shank, neglected type II diabetes. It is performed amputation of atypical necessity, right leg, transtarsal, open stump. After successive debridements, negative pressure therapy is installed for a period of 24 days. This favors the formation of the granular bed, the remission of the infection, allowing grafting. The graft is partially integrated and plantar reconstruction is performed with sural reversal flap. The local and functional results are satisfactory, with the flap viability and the possibility of moving with support on the right leg, preventing the amputation of the shank. Negative pressure therapy has a multitude of advantages, it is preferable to conventional therapies, and it can have higher costs, but accelerates healing and improves the quality of life of the patient.
CD10, CD34 and Ki67 Immunohistochemical Markers Expression in Endometriosis and Adenomyosis
Authors: Penciu Roxana-Cleopatra , Steriu Liliana , Izvoranu Silvia , Postolache Iulia , Tica Andrei-Adrian , Mocanu Diana , Tica Oana-Sorina , Sarbu Vasile , Deacu Mariana , Baltatescu Gabriela , Tica Irina , Petcu Lucian , Tica Vlad-Iustin
Published: January 2020

Endometriosis is a benign disease represented by existence of endometrial tissue outside the uterine cavity. Considered in the past a type of endometriosis, adenomyosis is, presently, described as a possible different entity, comparative to endometriosis. That is the reason why we decided to study two groups of patients - one with endometriosis and one with adenomyosis - in order to determine if they are one and the same disease. We included all successive patients admitted and surgically treated in the Emergency Clinical Hospital Constanta between 2015-2017, and, after applying the selection criteria, we assessed 61 patients (group 1) diagnosed with endometriosis - ovarian, cervical, caesarian section scar - and 39 patients (group 2) with adenomyosis. We studied all patients in terms of age, parity, lesions� size, admissions� symptoms, chronic symptoms and immunohistochemical markers CD10, CD34, Ki67. We chose there three markers because of their possible relation to endometriosis and because we were unable to find data regarding the comparison of CD34 or Ki67 expression in endometriosis and adenomyosis and because we did not find articles that reported the expression of these three immunohistochemical markers, combined, for either endometriosis or adenomyosis. According to our study, it seems that endometriosis and adenomyosis are different clinically with regard of age and dysmenorrhea, but there was no statistical difference between the studied immunohistochemical biomarkers� expression in samples of patients with endometriosis or adenomyosis.
Statistical Analysis Between the Routes of Administration of L-Dopa and Digestive Dysfunctions in Parkinson Disease
Authors: Criciotoiu Oana , Stanca Diana Iulia , Glavan Daniela-Gabriela , Mirea Cecil Sorin , Mita Adrian , Calborean Veronica , Gheorman Victor , Udristoiu Ion , Dijmarescu Anda Lorena , Davitoiu Dragos Virgil , Gheonea Dan Ionut
Published: January 2020

The aim of this study was to evaluate possible correlation between routes of administration of levodopa in patients diagnosed with Parkinson�s disease and the presence of digestive symptoms. We included in this study 31 patients diagnosed with Parkinson�s disease:14 patients were on oral levodopa and 17 patients were on intrajejunal administration of levodopa/carbidopa. Each patient was assessed using Non-motor Symptoms Questionnaire for Parkinson�s Disease regarding the dysfunction of gastrointestinal tract. The results of our study indicated that there is a different distribution of the digestive dysfunction between the two groups of patients. The study indicate that the constipation was more frequent in those patients with oral medication.
The Effects of Idazoxan and Efaroxan Improves Memory and Cognitive Functions in Rats Experimental research
Authors: Rusu-Zota Gabriela , Timofte Daniel Vasile , Albu Elena , Nechita Petronela , Sorodoc Victorita
Published: January 2020

Investigating the effects of idazoxan and efaroxan imidazoline receptor antagonists on cognitive functions with the rat Y-maze test; an internationally recognized experimental pattern of behavior, is to be used in order to evaluate the effects of test substances on the simple spatial memory of the laboratory animals. Our experimental evaluation tested the influence induced by idazoxan and efaroxan on the short-term memory on rats. In the experiment were used eighteen (18) male Wistar rats which were randomly divided into three groups (I - Control, II - IDZ and III - EFR) comprising of 6 animals each, treated intraperitoneally according to the following protocol: group I (Control): distilled water 0.5 mL/100 g body weight; group II (IDZ): idazoxan 3 mg/kg body weight; group III (EFR): efaroxan 1 mg/kg body weight. The purpose of this research was to assess the eligibility using the Y-maze test, involving: latency of the first arm visited, the number of arms visited, and the time spent into the arms, the number of returns of the experimental animals in the same arm, the number of alternations, percentage of spontaneous alternation. In this work, manifestations of the natural behavior of the animals tested was expressed by their choice of goal arm alternation. Statistical data processing reveals that: the administration of IDZ, as well as of EFR was accompanied by a tendency to enter a less recently visited arm and reduced the total number of arms visited, statistically significant (p[0.05) compared to control group. In this experiment, the use of these two imidazoline receptor antagonists did not considerably influence the reference memory, when pursuing the latency of the first arm visited, compared to the group treated with distilled water. The effects of IDZ and EFR on the percentage of time spent in the arms were sorted in descending order in this behavioral experimental model (IDZ]Control]EFR). The results demonstrate that the treatment with imidazoline agents optimizes the cognitive function of the animals, improving their learning ability, in the rat Y-maze Test. Regular exercise can reduce depression-, anxiety-, and impaired cognitive-like behaviors, and in conclusion these substances would be a useful pharmacological agents for the treatment of cognitive dysfunction.
Study of Phytotoxic Effects of Cu2+ and Cd2+ on Seed Germination and Chlorophyll Pigments Content to the Bell Pepper
Authors: Iosob Gabriel-Alin , Nedeff Valentin , Sandu Ion , Prisecaru Maria , Cristea Tina Oana
Published: January 2020

Phytotoxic effects of Cooper and Cadmium have been studied on germination of seeds and the content of chlorophyll pigments.The experiment was completed in accordance with OECD Protocol 208 (Guidelines for the Testing of Chemicals) and four concentration levels for Cu were used (16, 80, 200, 400 mg�kg soil) in the chemical form of CuSO4 and four concentration levels for Cd (0.8, 2.4, 4, 8 mg�kg soil) standard solution for atomic absorbtion standard solution (AAS), Both Cu and Cd have been embedded in the soil.The results show that the effect of inhibiting seed germination of bell pepper is higher in soil contaminated with Cd compared to soils contaminated with Cu. Chlorophyll pigments were extracted from fresh green leaves in an alcoholic extract and quantified using Lichtenthaler�s equations (1987), however, the determination of chlorophyll pigments (chlorophyll a, b, carotenes) from bell pepper leaves shows a rather large increase in the coefficients of variation. Therefore, we can conclude that the toxic compounds (Cu and Cd) induce structural and functional changes in the bell pepper photosynthesis mechanism.
The Role of Anticoagulant Therapy in the Prevention of Preeclampsia Pharmacokinetic and pharmacodynamic mechanisms
Authors: Turcan Natalia , Bohiltea Roxana , Neacsu Adrian , Baros Alexandru , Cirstoiu Monica Mihaela
Published: January 2020

Pregnancies complicated with preeclampsia associate a high incidence of intrauterine fetal death, intrauterine growth restriction, premature ruptures of membranes, abruption placentae and prematurity. Understanding the pathogenesis of preeclampsia is mandatory for a correct approach and prevention management of high risk cases. Placental hypoperfusion seems to be a key factor in developing systemic resounding. By placental necrosis and apoptosis, cell-free DNA is released in maternal circulation in early pregnancy, respectively prior 17 weeks of gestation. There is no test, useful in early pregnancy, accurate enough to predict preeclampsia. Various screening test have been proposed in order to predict the development of preeclampsia, but most of them are not sufficiently accurate for general screening. There is a continuous debate regarding the algorithm of administration, doses and timing of low dose aspirin. The initiation moment is crucial, as the administration after the development symptoms and signs of preeclampsia do not interfere with the progression and the severity of the disease. Early initiation of therapy with low dose aspirin, prior the end of the first trimester is important since the pathogenesis mechanisms of preeclampsia take place in the first trimester. The action of acetylsalicylic acid consists in inhibition of COX-1 and COX-2 (cyclooxygenase isoenzymes), necessary for prostaglandin biosynthesis. Preferential inhibition of Thromboxane A2 by low dose aspirin, counterbalance the increased production of thromboxanes characteristic to preeclampsia and modulate the inflammatory process, amplified in pregnant women with preeclampsia.
OCT Application in Direct Dental Restorations Marginal Fit Evaluation
Authors: Popescu Sanda Mihaela , Lascu Luana , Gingu Oana , Mercut Veronica , Osiac Eugen , Scrieciu Monica , Tuculina Mihaela Jana , Draghici Emma Cristina , Manolea Horia Octavian , Moraru Alina Iren
Published: January 2020

To apply OCT analysis in secondary caries and marginal gap detection and evaluation for direct dental restorations is the aim of the paper. 15 extracted teeth with pre-existing direct dental restorations were analysed through OCT to evaluate marginal fit of restorations. The OCT system used wasmanufactured by Thorlabs (OCS1300SS), powered by a swept laser source with central 1310 nm wavelength, 100 nm spectral bandwidth and 12 mW average power. The occlusal area of the teeth was sampled pictured in 10 mm width, 10 mm distance and 3 mm depth. OCT was used also to evaluate in micrometers (mm) the maximum marginal gap between dental filling and tooth. OCT analysis of the marginal fit of direct dental restorations after A scan examination revealed that amalgam had the smallest marginal gap (width 210 mm, depth 90 mm), followed by glass ionomer (width 350 mm, depth 280 mm), and composite (width 520 mm, depth 300 mm). OCT analysis revealed that for marginal fit evaluation amalgam had best performance, followed by glass ionomer, and ultimately, by resin composite. OCT could be used as an alternative method to appreciate the marginal fit of direct dental restorations giving details that could help dentists to take best treatment decision, whether to repair or to replace the restorations.
Evaluation of the Biocompatibility and Graft Integration Following Ligamentoplasty or Augmentation. Experimental study on rabbits
Authors: Chitea Claudiu , Tomoaia Gheorghe , Toader Oana D. , Milea Claudia , Trante Octavian , Earar Kamel , Saceleanu Vicentiu
Published: January 2020

Several techniques are used to reconstruct the anterior cruciate ligaments (ACL) by using different grafts in order to obtain a new ligament with properties closest to those of the healthy one. Our aim was a faster graft harvesting and the integration into the bone tissue; we have studied the efficiency of the techniques that preserve the torn ligament end vs. the techniques that used a graft harvested from the patient. The ligamentoplasty studies performed on rabbits reveal a satisfactorily cost-efficiency ratio, this being the main reason for choosing this model. We wanted to study the importance of preserving one edge of the torn ligament as a base of integration for the new graft and compare the appearance of the blood vessels and the neoformation tissue in the two study groups. For the first study group we performed an implantation technique that uses a complete new graft harvested from the same animal and for the second group we used the technique which preserves the torn ligament. All the surgical procedures were conducted on the NZW rabbits. All ligamentoplasty reconstruction surgical interventions were conducted on the left limb and the graft was harvested from the extensori digitorum longi located on the lateral side of the rabbit�s thigh. Twelve rabbits in each group were operated upon using the two techniques and the results were compared. No major complications were noted, the long term results were similar, and with no significant differences as far as the ligament integration was concerned. The study group in which the ligament end was preserved showed a more rapid integration. Our study suggests that keeping a longer ligament end correlates with early graft integration.
Structural Analysis of Thin Ni-P Layers
Authors: Alexandru Petrica , Radu Tamara , Potecasu Florentina , Vlad Maria , Istrate Gina Genoveva , Buruiana Daniela L. , Carp Bogdan-Gabriel
Published: January 2020

The deposition mechanism by autocatalytic reduction method is a chemical one, which does not lead to structures as shown in the Ni-P balance diagram. In the experiments of the present work, Ni-P layers were made deposited on thin steel strip with low carbon content. By optical microscopy and scanning electron microscopy by (SEM) it was analyzed the appearance and surface morphology of the deposited layers depending on the content of phosphorus and working parameters (temperature, pH, stirring speed). The layer structure was analyzed in the cross section and on the break surface. The analysis results show that thin coatings of Ni-P have a surface topography that follows faithfully the steel support. Depending on the content of phosphorus, on the layer surface of low phosphorus content, spherical particles of different sizes can be seen while high and average phosphorus content coatings feature a smooth surface with nanometer-sized grains. Analysis of the cut-off /break section of the Ni-P layer structure, show a more or less porous structure depending on the stirring speed and pH level.
The Production of the Isotope 15N by Isotopic Exchange in Nitrox System at Pressure
Authors: Axente Damian , Bugeac Stefan , Gergely Stefan , Gligan Mihai , Marcu Cristina , Szucs Zsolt , Varodi Codruta
Published: January 2020

The operation of 15N production plant at pressure of 0.7 +/- 0.05 bar in stable conditions at total reflux and in production is demonstrated. The 10M HNO3 flows used in the primary column were 6.6 L/h and 6.0 L/h, 47, respectively 33% higher than that of atmospheric pressure (4.5 L/h) and corresponding flow rates of the same column were 3.12 mL/cm2. min, respectively 2.83 mL/cm2.min for operation at pressure, compared to 2.12 mL/cm2�.min at atmospheric pressure. The 10M HNO3 flows used in the final column were 324 mL/h and 264 mL/h, 62, respectively 32 % higher than that of the atmospheric pressure (200 mL/h) and flow rates of that column were: 3.05 mL/cm2.min, respectively 2.49 mL/cm2.min, compared to 1.86 mL/cm2�.min for atmospheric pressure operation. The HETP values are lower for both separation columns operated at pressure and higher 10M HNO3 flow rates, that being an argument in the favour of operation the 15N production plant by isotopic exchange in Nitrox system at pressure. The nitrogen enriched in 15N losses in the waste sulphuric acid, evacuated at the bottom of product refluxer stage II, were : 5.18 -10.58 ppm of feeding with 10M HNO3 of the plant. Any losses of nitrogen enriched in 15N represent an additional uncontrolled production, which diminishes the production of 15N plant. In the case of operation at pressure the flows of H15NO3 extracted as plant product are higher than those corresponding to atmospheric pressure because the nitric acid solution is chemically equilibrated with nitrogen oxides at the operation pressure and temperature. At a pressure of 1 atm. in the 15N production plant the nitrogen content of nitric acid solution would be 10.919M instead of 10M.
Impact of Material Serum Screening in Early Prenatal Diagnosis and Management of Congenital Anomalies
Authors: Albu Cristina-Crenguta , Cilievici Suzana Elena , Albu Dinu-Florin , Albu Stefan-Dimitrie , Patrascu Anca , Goganau Alexandru Marian
Published: January 2020

It was performed a case-control study, that included totally 187 pregnant women hospitalized in Obstetrical-Gynecology Department of Prof. Dr. Panait Sarbu Hospital, Bucharest, Romania. The selection criteria for case sample were: age over 30 years, history of malformative risk, clinical exam that emphasised malformations and ultrasound examination that suspicioned embrio-fetal morphological abnormalities. We determined the serum levels of alpha fetoprotein (AFP), human chorionic gonadotropin (hCG) and unconjugated estriol (uE3), by immunoenzymometry. As statistical analysis we determined the estimated median value. For each of the three parametres, the final curve was compared with the value obtained by spectrophotometry. The study revealed the predictive value of correlated use of these three parameters, together with ultrasound examination and cytogenetic investigations, in order to early prenatal diagnosis of congenital fetal anomalies.
Synthesis of 4-(2-Hydroxy-5-methylphenyl)-1,3-Dithiol-2-ylidene Derivatives
Authors: Lungu Catalin Neculai , Asaftei Iuliean Vasile , Sandu Ion , Chirita Paul , Bahrin Lucian Gabriel
Published: January 2020

The reaction of 4-(2-hydroxy-5-methylphenyl)-1,3-dithiolium perchlorates with various methylene active compounds has provided the corresponding 1,3-dithiol-2-ylidene derivatives. The reactions have been performed under basic conditions using DBU. The newly obtained derivatives were characterized by NMR, MS spectrometry and IR spectroscopy.
Eco-materials for Arsenium and Selenium Removal from Aqueous Solutions
Authors: Minzatu Vasile , Davidescu Corneliu Mircea , Ciopec Mihaela , Negrea Petru , Duteanu Narcis , Negrea Adina , Motoc Marilena , Manea Aniko
Published: January 2020

Environmental engineering have a great importance because is dealing with different fields, most important of them being water resource protection. It is well known that natural waters and especially groundwater contain dissolved substances, most of them unharmful for human and animal life, but some of them still potentially harmful. Ground waters containing dissolved arsenic and / or selenium are harmful and not suitable for human an animal life. Selenium represents a human life prerequisite microelement which can become toxic when higher quantities are ingested or accumulated. In comparison arsenic has an acute toxic effect over the human body even when very low quantities are ingested. In both cases the maximum amount were limited by OMS at 10 mg L-1. A new technique was used to produce an ecofriendly composite material by doping graphite with iron oxide, which was used for retention of arsenic and selenium from aqueous solutions. Synthesized material was characterized using SEM, EDX, XRD and DTA. Adsorption capacity and adsorption mechanism were established through equilibrium studies. Maximum adsorption capacity was 400 �g As(V) and 625 �g Se(VI) per gram of adsorbent.
The Heat Stress Effects on the Gases Permeability of the Isolative Type Garment of the Czech Armed Forces Chemical Corps Specialists Body Surface Protection
Authors: Otrisal Pavel , Friess Karel , Feherova Lucia , Melicharik Zdenek , Svorc Lubomir , Bungau Constantin , Mosteanu Danut-Eugeniu
Published: January 2020

In our research, both theoretical and practical approaches to the assessment of permeability of barrier materials used to produce protective garments of an isolative type designed for body surface protection have been studied. The main goal of this paper is to study the thermal resistance for a barrier material of the ventilated anti-gas isolative garment OPCH-05 which is used in the conditions of the Czech Armed Forces for the Chemical Corps specialists� protection against the effects of toxic compounds. The thermal analysis of samples was performed using the differential scanning calorimetry, the surface structural changes were determined via the 3D optical profilometer and the gas permeation measurements were performed by means of the integral permeation method. Based on permeation results, the appropriate time limits and the temperatures of the exposure, during which the chemical protective garment could be securely used, were evaluated.
Impact of Prolactin Hipersecrey on Glucid and Lipid Metabolisms
Authors: Ionescu Elena , Cotoi Bogdan Virgil , Ganescu Anca
Published: January 2020

Pituitary is a common terrain for the appearance of tumoral changes, representing the origin of about 15% of all intracranial tumors [13]. These tumors are, for the most part, histologically benign, as they arise from hormone secreting cells in the anterior lobe. Therefore, the aim of the paper is to specify the clinical and paraclinical clinical onset characteristics, the evolutionary peculiarities, as well as the metabolic complications secondary to the prolactin hypersecretion. The effects of prolactin-secreting pituitary tumors may occur as a result of mass effects of tumors or even hyperprolactinaemia. Because microadenomas are intrathecal, visual defects may not occur, but headaches occur more often (50%) than normal (27%) [1, 6]. A large tumor that extends beyond the limbs of the turkey can cause headaches and vision defects. The classical presentation is bitemporal hemianopsia due to the compression of the optic chiasm from a tumor that extends to the upper level. If chiasma is prefixed or if the tumor extends posteriorly, compression of a single optical system results in visual field defects similar. The lateral extension in the cavernous sinus can lead to the illness of the oculomotor function involving the cranial nerves III, IV and VI and the branches V1 and V2 of the cranial nerve V, alone or in combinations.
Research Related to Capsular Contracture after Breast Augmentation for Cosmetic or Reconstructive Purposes
Authors: Marinescu Silviu Adrian , Enescu Dan Mircea , Bejinariu Catalin Gheorghe , Giuglea Carmen
Published: January 2020

The upward trend of patients opting for elective breast augmentation, as well as the large number of patients benefiting from alloplastic breast reconstruction, require further studies on the safety profile of these techniques. Without any doubt, the incidence of Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) has drawn attention to the possible unknown complications characteristic of these procedures, creating the context of further studies devoted to this issue. The present research examines the capsular contracture rate on a group of 253 patients between 2015 and 2019, also proposing a scoring system based on the integration of the main diagnostic criteria related to the capsular contracture. The results of the literature review indicate that a lower incidence of capsular contracture could be achieved by using the newest techniques in the field involving the application of chemical substances on the surface of the latest generation of silicone breast implants.
Comparative Study of Color Stability of Three Composite Materials, Treated by Finishing and Coated Sealing, After Immersion in Different Wholesale
Authors: Bolat Maria , Stoleriu Simona , Iovan Viorica , Iovan Gianina , Pancu Galina , Sandu Andrei Victor , Taraboanta Ionut , Andrian Sorin
Published: January 2020

The present study was conducted to evaluate the effects of common drinks consumed by patients (Coffee, Coca-Cola, Black Tea) on different types of composite restorations, finishing and surface sealing (nanocomposites, nanohybrids, ormocers) regarding color changes. 45 specimens of composite materials (Nanoceramic, Nanocomposite and Nanohybrid) were made and divided into 3 groups G1-control group, G2 - finished in 2 stages, and G3 glaze coated. The LOVIBOND RT 300 portable spectrophotometer was used to determine the color by following the CIELAB scale. The data was analyzed using Mann-Whitney followed by a multiple comparison t test. Significant differences were found between the groups in terms color changes (p[0.001). The results showed that for both groups of composites (G2 and G3), irrespective of the beverage they were immersed in, the DE values were significantly higher at 7 days compared with the 30 day values.
Anorexia, a First Sign of Diagnosis in Severe Pediatric Disorders
Authors: Nedelcuta Ramona-Mihaela , Calin Gigi , Baleanu Vlad Dumitru , Davitoiu Dragos Virgil , Voiculescu Daniel-Iulian , Mirea Cecil Sorin , Tenea Cojan Tiberiu Stefanita , Socea Bogdan , Alexandru Dragos Ovidiu , Clenciu Diana , Gheorman Victor , Udristoiu Ion , Calborean Veronica , Ciora Cosmin Alexandru
Published: January 2020

Anorexia, as a symptom, is part of the complex picture of a large pediatric pathology. Through attentive observation, anorexia as a single sign, may announce the onset of serious and particular affections. In all 4 cases, anorexia was a singular sign for a period of time before the complete illness was established. Whether adenoid cyst, cerebral abscess, pontocerebellar atrophy, Wilms tumor, neuroendocrine system of hunger regulation, satiety, complex control achieved through interactions of the limbic-hypothalamus-cortex system, come into operation with the occurrence of organic anorexia, different of the psychogenic anorexia (usually common in adolescents). The study is an alarm signal on the importance of a symptom in early diagnosis, and the rapid establishment of therapy in severe life threatening conditions.
The Influence of Diabetes Mellitus on Sodium Homeostasis in Patients with Preserved Ejection Fraction Heart Failure
Authors: Buse Alexandru-Madalin , Nanea Ioan Tiberiu , Nicolae Camelia , Plesa Cristina Florentina , Nemes Roxana Maria , Bisoc Alina , Diaconu Magdalena , Paunescu Alina , Tantu Monica Marilena
Published: January 2020

The objective of the study was to analyze the characteristics of the patients with preserved ejection fraction heart failure (HfpEF) who develop hyponatremia, in relationship with the diabetes mellitus (DM). The current study is an observational retrospective one, that included 36 patients(25 women, 11 men), aged 66.6� 3.1 years, hospitalized for decompensated chronic heart failure, with a left ventricular ejection fraction ]40%. 33% (n=12) of the enrolled patients had hyponatremia, which was strong associated with DM (75% vs 17%, p[0.0005). In hyponatremic patients group was no association between DM and age, gendre, smoking, artrial hypertension, dyslipidemia, ejection fraction distribution or NTproBNP. As for medication at admission, we found an association of the presence of DM with betablockers(100% vs 67%, p[0.05) and with statins( 89% vs 67%, p[0.05). In our study, DM and non-DM patients with low serum sodium values and HfpEF have quite similar clinical profile, since the differences we found do not explain the high prevalence of DM in hyponatremic patients. As a conclusion, the presence of DM itself may explain the high prevalence of DM in hyponatremic patients, but is necessary to have larger studies with more variables included to assess HFpEF patients with DM and hyponatremia.
Influence of Various Types of Waste on the Main Properties of Gypsum Based Composites for Thermal Insulations
Authors: Dima Cristina , Badanoiu Alina , Stoleriu Stefania , Luca Diana
Published: January 2020

In the last decade numerous research studies were performed in the attempt to recycle several types of industrial waste. This study has as main objective the obtaining and characterization of gypsum based composite materials with various amounts of industrial wastes (flue gas desulfurization gypsum and recycled rubber). The main properties assessed for these materials were setting time, compressive strength, apparent density and thermal conductivity. The gypsum binder was partially replaced with thermally treated flue gas desulfurization gypsum (FGDgp_t) without an important negative impact on the compressive strength; if the replacement amount is up to 40 wt.% the resulted binder still meets the requirements imposed for this property by specific norm for gypsum plaster - EN 13279-1. The substitution of gypsum plaster with FGDgp_t shortens the setting time, therefore it was compulsory to use also sodium citrate as retarder addition. The addition of 5 wt.% rubber waste has a positive effect on the thermal conductivity of composite materials based on gypsum binder with/without FGDgp_t. Consequently, these materials could be used for the manufacture of low cost, eco-friendly thermal insulation materials.
MicroCT Analisys of Dental Adhesives Loaded with Nanoparticles
Authors: Zaharia Cristian , Sinescu Cosmin , Gabor Alin-Gabriel , Cojocariu Andreea Codruta , Socoliuc Vlad , Szuhanek Camelia , Negrutiu Meda-Lavinia
Published: January 2020

Dental decay is an infectious disease that affects more and more people. Dental Restoration Materials are not infallible, after filling a tooth with composite materials, and secondary caries may appear. One of the possible causes involved in the appearance of secondary caries is generated by the uneven thickness of the layer of adhesive that can be fractured by microinfiltration areas. The purpose of this study is to evaluate a new type of dental adhesive that has been loaded with ferric nanoparticles. The thickness of the adhesive layer used in the restoration of the various types of cavities on the surface of the teeth, which were coated with copolymerizable composite materials, was evaluated, making a comparison between the thickness of the uncoated adhesive layer and the thickness of the adhesive loaded with ferric nanoparticles.In this study, 20 extracted teeth were used which presented various carious lesions. The dental caries were removed resulting class I and II Black cavities. The restoration of the cavities was made using adhesive techniques and photopolymerizable fluid-type composites, the adhesive layer being analyzed by the microCT.
The Characterization of Antibiotic Resistance of Bacterial Isolates from Intensive Care Unit Patient Samples in a University Affiliated Hospital in Romania
Authors: Golli Andreea-Loredana , Nitu Floarea Mimi , Balasoiu Maria , Lungu Marina Alina , Dragomirescu Cristiana Cerasella , Olteanu Madalina , Nemes Roxana Maria , Tantu Monica Marilena , Olteanu Mihai
Published: January 2020

To determine the resistance pattern of bacterial pathogens involved in infections of the patients aged between 18-64 years, admitted in a ICU from a 1518-bed university-affiliated hospital. A retrospective study of bacterial pathogens was carried out on 351 patients aged between 18-64 years admitted to the ICU, from January to December 2017. In this study there were analysed 469 samples from 351 patients (18-64 years). A total of 566 bacterial isolates were obtained, of which 120 strains of Klebsiella spp. (35.39%%), followed by Nonfermenting Gram negative bacilli, other than Pseudomonas and Acinetobacter (NFB) (75- 22.12%), Acinetobacter spp. (53 - 15.63%), Pseudomonas aeruginosa and Proteus (51 - 15.04%), and Escherichia coli (49 - 14.45%). The most common isolates were from respiratory tract (394 isolates � 69.61%). High rates of MDR were found for Pseudomonas aeruginosa (64.70%), MRSA (62.65%) and Klebsiella spp. (53.33%), while almost all of the isolated NFB strains were MDR (97.33%). There was statistic difference between the drug resistance rate of Klebsiella and E. coli strains to ceftazidime and ceftriaxone (p[0.001), cefuroxime (p[0.01) and to cefepime (p[0.01). The study revealed an alarming pattern of antibiotic resistance in the majority of ICU isolates.
Diabetes Mellitus raise the Risk for Interval Colorectal Cancer and Advanced Colorectal Adenomas
Authors: Suceveanu Andra Iulia , Mazilu Laura , Nitipir Cornelia , Stoian Anca Pantea , Parepa Irinel , Voinea Claudia , Suceveanu Adrian Paul
Published: January 2020

Interval colorectal cancer (ICRC) means CRC discovered at or before the second colonoscopy during a screening interval. Literature provides data concerning the present issue, 7.2-9% of CRCs meeting the definition of interval CRC, without knowing the risk factors for this. We aimed to study if diabetes mellitus (DM) patients have a greater risk to develop ICRC/advanced adenomas (ACRA). We randomly included in the study 50 patients aged over 50 years old diagnosed with DM in whom colonoscopy was done for different reasons. Were excluded patients with CRC/ACRA diagnosed at first colonoscopy and results were compared to those of an age/gender-matched group of patients without DM as background. The interval of colonoscopies was fixed at 36 months (the shortest interval used for surveillance after a polypectomy). The total number of interval lesions significantly differs in our two groups (p=0.022, q=0.17). Interval CRC, serrated adenomas and villous adenomas were more frequent in the T2D group. (p = 0.013, p= 0.032, respectively p=0.011, q=0.14). DALM lesions were more frequently present in controls than in T2D (p=0.049) Results showed that patients with interval ICRC were two times more in DM group in male gender (p=0.003, ss) (4 pts, respectively 2 pts) and 1.5 times greater in female group (3 pts, respectively 2 pts). The rate of CRC occurrence during the interval period of 36 months was 0.16% for male and 0.12% for females. Regarding the occurrence of ACRA (villous/tubulovillous adenomas), male patients with DM had 3 times more ACRA lesions than the control group (p=0.029, ss) (9 pts vs 3 pts) while females patients with DM had 2 times more ACRA than controls (p=0.031, ss) (6 pts vs 3 pts). The rate of interval advanced CR lesions occurrence during the interval period of 36 months was 0.36% for male and 0.24% for females. DM looks be a risk factor ICRC/ACRA by accelerating the colorectal epithelial proliferation rate. Male gender looks to be more exposed to ICRC/ACRC, especially when they are diagnosed with metabolic co-morbidities like T2D.