bluuebunny/crossref_metadata_2025 huggingface dataset:
A atuação da Equipe Multidisciplinar na Redução da Pneumonia Associada à Ventilação Mecânica: Estratégias de Prevenção e Manejo
Authors: Silva Elen Sousa de Abreu , Oliveira Roberta Paixão de , Bacelar Albert , Medeiros Maria Patrícia de , Santos Isabella Peixoto dos , Oliveira Kelly Albuquerque de , Reis Andreia Almeida Guedes , Santos Luis Fernando Simões dos , Costa Karolyne Lopes da , Coimbra Tânia Fagundes , Mota Ana Beatriz Oliveira da , Santana Maria Anunciada de Souto
Published: February 2025

A pneumonia associada à ventilação mecânica (PAVM) é uma das principais infecções adquiridas em unidades de terapia intensiva (UTI), representando um grande desafio para a equipe multiprofissional. Este estudo realizou uma revisão integrativa da literatura para analisar as principais estratégias preventivas, os desafios na implementação de protocolos e a eficácia das intervenções na redução da morbidade e mortalidade. Foram selecionados 14 estudos a partir de bases científicas, demonstrando que a adoção de bundles, a capacitação contínua da equipe e a padronização de protocolos assistenciais reduzem significativamente a incidência de PAVM. Os resultados mostraram que intervenções como elevação da cabeceira do leito, higiene oral com antissépticos, aspiração subglótica contínua e monitoramento da pressão do cuff do tubo endotraqueal estão associadas à menor taxa de infecção. No entanto, a baixa adesão a protocolos, a variabilidade na aplicação das diretrizes entre instituições e a necessidade de maior integração da equipe multiprofissional foram identificadas como barreiras para a prevenção eficaz da PAVM. Além disso, a inclusão do cirurgião-dentista na equipe foi apontada como uma estratégia promissora para melhorar a higiene oral e reduzir a colonização bacteriana na via aérea. Conclui-se que a prevenção da PAVM depende da atuação coordenada da equipe multiprofissional, do treinamento contínuo e da adoção de medidas baseadas em evidências, garantindo maior segurança para os pacientes ventilados e reduzindo complicações associadas à ventilação mecânica.
Impacto dos Bloqueios Regionais na Estratégia de Analgesia Multimodal em Cirurgias Cardíacas: Uma Revisão da Literatura
Authors: Pires Pereira da Silva Juliane , Carneiro de Oliveira Alexandre , Martins do Egito Filho Cesar , De Araújo Roque de Souza Cintia Alessandra , Olegario de Almeida Pajuelo Guilherme , Mendanha Carvalho Pedro Henrique , Carvalho Matos Gabriel , De Paiva Marques Carvalho Tayná , Lazzari Branquinho Paula , Barbosa Renan Bruno , Amaro Castelan Laura
Published: February 2025

Este artigo tem por objetivo realizar uma análise da literatura médica vigente sobre o impacto dos bloqueios regionais na analgesia multimodal em cirurgias cardíacas. Foram utilizados como motores de busca os indexadores PubMed, Scopus, Web of Science e Embase para seleção dos artigos, através dos termos “bloqueios regionais, analgesia multimodal, cirurgia cardíaca, recuperação pós-operatória”. Conclui-se que os bloqueios regionais apresentam benefícios significativos na redução da dor pós-operatória, do consumo de opioides e do tempo de recuperação, demonstrando serem uma ferramenta valiosa na analgesia multimodal em cirurgias cardíacas.
PERFIL DAS INTERNAÇÕES POR MENINGITE VIRAL NO BRASIL: UMA ANÁLISE EPIDEMIOLÓGICA (2014–2024)
Authors: Brito Pedro vitor maia bettini , Paiva Mateus de Castro , Samesima Gabriel Takesi , De Araujo Mayara Vedovati Ferraz , Coelho Geovane Alves , Berbert Vera Sofia , Cardoso Leone Romagnoli , Doetzer Karin Hauer , Cubo Bárbara Bach , Contin Ana Clara Slonski , Cesnik Eloá Vicentin , Santini Gabriel Brandão Campano , Ducini Ellen Cristina Prado , Simões Vitória Moreno , Paiva Andressa Carolina Nunes , Picolo Eduardo Henrique , Ferrari Luis Eugênio Pacheco , Lovatel Vittoria Beatriz Cauton , Cardoso Lucas Alan , Iora Giovana
Published: February 2025

Este artigo tem por objetivo analisar a epidemiologia das internações por meningite viral no Brasil no período de 2014 a 2024. Trata-se de uma pesquisa descritiva, transversal e epidemiológica. Os dados acerca das internações por meningite viral foram obtidos através do Sistema de Informações Hospitalares do Departamento de Informática do Sistema Único de Saúde (SIH/DATASUS), considerando o período de 2014 a 2024. As variáveis analisadas incluíram sexo, faixa etária, raça e número de internações por ano. No período analisado, foram registradas 26.424 internações por meningite viral no Brasil. Observou-se uma maior concentração de casos na Região Sudeste (42,7%) e uma predominância no sexo masculino (57,1%). As crianças menores de 1 ano (16,84%) e aquelas entre 1 e 4 anos (18,89%) foram os grupos etários mais afetados. Esses dados ressaltam a relevância da meningite viral para a saúde pública e a necessidade de aprimorar estratégias de prevenção, diagnóstico precoce e manejo adequado da doença.
PREVALÊNCIA DE INTERNAÇÕES POR UROLITÍASE NO BRASIL
Authors: Veloso Fernanda Moreira Fagundes , Fonseca Fernando Guimarães , Pessoa Iury Marcos da Silva , Ferreira Ana Célia Guedes Roque
Published: February 2025

Objetivo: Analisar a prevalência de internações por urolitíase no Brasil entre janeiro de 2014 e junho de 2024. Metodologia: Trata-se de um estudo epidemiológico, retrospectivo, descritivo e quantitativo, baseado em dados secundários. As informações foram extraídas do Sistema de Informações Hospitalares do SUS (SIH/SUS) por meio do Departamento de Informática do SUS (DATASUS). Foram analisadas variáveis como o ano da internação, sexo, faixa etária, cor/raça, caráter da internação e distribuição geográfica. Resultados: No período avaliado, foram registradas 909.341 internações por urolitíase no Brasil. Houve predomínio de internações no ano de 2023 (12,74%), no sexo masculino (50,49%), na faixa etária entre 40 e 49 anos (22,29%) e cor/raça branca (45,05%), em caráter de urgência (71,08%), com maior incidência na região Sudeste (46,61%). Conclusão: A alta prevalência de internações por urolitíase, especialmente em adultos de meia-idade e nas regiões Sudeste e Sul, ressalta a necessidade de estratégias preventivas e de aprimoramentos no manejo clínico, visando à redução de hospitalizações e aos impactos no sistema de saúde.
ECONOMIA E SAÚDE MENTAL: O IMPACTO DA INSTABILIDADE FINANCEIRA NO BEM-ESTAR PSICOLÓGICO
Authors: Goulart Maria Joaquina Barbosa , Machado Gabriela Fernanda , Gonzaga Mariana Ramos , Leal Renata Teixeira , Jorge Giovana Diniz , Guilherme Gizela Passi Sady , Brito Diego Oliveira , Sousa Viviane Albuquerque Pinto de , Cananosque Neto Henrique , Lopatiuk Carlos
Published: February 2025

A conexão entre economia e saúde mental é um problema que vem ganhando cada vez mais relevância, especialmente durante períodos de crise financeira, quando a instabilidade econômica tende a piorar distúrbios psicológicos e a dificultar o acesso a cuidados adequados. Nesse contexto, adotar uma abordagem multidisciplinar torna-se fundamental. Isso implica a colaboração de economistas, psicólogos, assistentes sociais e formuladores de políticas públicas na criação de estratégias eficazes para amenizar os efeitos da vulnerabilidade financeira sobre a saúde mental. Dessa maneira, investir em redes de suporte, educação financeira e políticas públicas bem elaboradas pode contribuir para um ambiente socioeconômico mais equilibrado e saudável. O presente estudo visa investigar a relação entre instabilidade financeira e saúde mental, destacando fatores de risco e proteção, além de estratégias para reduzir os efeitos negativos desse fenômeno. Para isso, realizamos uma revisão narrativa da literatura, examinando estudos científicos recentes disponíveis em bases de dados como Scielo, PubMed e Google Scholar. Selecionamos artigos que discutem a intersecção entre economia e saúde mental, a relevância da multidisciplinaridade nas políticas públicas e os efeitos da instabilidade financeira no bem-estar psicológico. Os critérios para inclusão abarcaram publicações dos últimos 7 anos com uma análise profunda do tema, enquanto os de exclusão se referiram a estudos sem fundamentação empírica significativa. Os resultados da literatura apontam que a participação de profissionais de diferentes áreas é crucial para o desenvolvimento de estratégias eficazes em prol da saúde mental. Pesquisas mostram que a presença de redes de apoio social, em conjunto com políticas públicas que promovem a inclusão socioeconômica, pode diminuir consideravelmente os efeitos adversos da instabilidade financeira sobre o bem-estar psicológico. Além disso, iniciativas como programas de educação financeira têm se mostrado benéficas para reduzir o estresse financeiro e fortalecer a resiliência emocional. Contudo, persistem desafios, principalmente em nações com desigualdades estruturais, onde o acesso a tais recursos ainda é restrito.Em suma, a abordagem multidisciplinar é essencial para lidar com os desafios gerados pela relação entre economia e saúde mental. A cooperação entre diversas áreas do conhecimento possibilita o desenvolvimento de políticas e estratégias mais amplas e eficazes, que podem mitigar os impactos da instabilidade financeira e favorecer um ambiente socioeconômico mais estável e saudável. Portanto, investimentos em políticas públicas intersetoriais, programas de apoio psicológico e iniciativas educacionais são fundamentais para a melhoria da saúde mental da população.
ASSESSING THE EFFECTIVENESS OF INDUSTRY-ACADEMIA COLLABORATION IN CSR-FUNDED SKILL DEVELOPMENT PROGRAMS: A CASE STUDY APPROACH
Authors: Dr. Shaji. K. Joseph  , Priyanka Yadav
Published: February 2025

This study assesses the effectiveness of Corporate Social Responsibility (CSR)-funded skill development programs in India, focusing on industry-academia collaborations. Using a mixed-methods approach, the research evaluates four CSR-funded programs, analyzing employment outcomes, industry feedback, and stakeholder perspectives. The findings indicate that programs with active industry participation, well-structured curricula, and NGO involvement achieve higher employment rates (65-90%) and employer satisfaction. The study highlights the importance of strengthening industry-academia partnerships, improving curriculum relevance, and enhancing evaluation frameworks to maximize the impact of CSR-driven skill development initiatives. The research contributes to the existing literature on CSR's role in education and workforce development, providing empirical evidence on effectiveness metrics for CSR-funded skill development programs in India.
KEYWORDS: Corporate Social Responsibility, Funded Skill Development Program, Industry-Academia Collaboration, Education and Workforce Advancement.
GLOBAL CLIMATE CHANGES: ASSESSMENT AND EUROPEAN PERSPECTIVES FOR ITS PREVENTION
Authors: Belova Iryna , Sydoruk Borys , Senyk Ivan , Sydoruk Halyna
Published: February 2025

Introduction. Climate changes and the resulting global warming, which have been observed in recent decades on a global scale and in Ukraine in particular, pose a threat to the existence of humanity and require urgent measures to combat them. The world community has adopted a number of important documents, which should regulate the issue of emissions of greenhouse gases (methane and carbon dioxide) into the atmospheric air and thus prevent the further increase in the temperature regime of our planet.
Methods. The methods of systematic and comparative analysis and empirical research were used during the study. Data collection was carried out by analysing scientific publications, regulatory and legal framework and informational materials of NASA.
Results. There is an increase in air temperature in the global dimension, compared to the base period of 1951-1980, and in 2024 it was 1.28°C.
This process is inextricably linked with the increase in carbon dioxide content in the atmosphere. From 1958 to 2024, the content of CO2 in the atmosphere increased by 109.4 ppm or by 34.7% and amounted to 424.6 ppm. In addition to carbon dioxide, methane is a greenhouse gas, which has a much greater effect on global warming than carbon dioxide. Since the beginning of planetary observations from 1983 to 2024, its concentration in the air increased by 290.8 ppb from 1636.6 to 1927.4 ppb or by 17.8%.
One of the ways to solve the issue of reducing the content of greenhouse gases, primarily CO2, is its sequestration by annual intermediate, siderable and cover crops.
Discussion. In this regard, the study of the issue of effective cultivation of intermediate, sideral and cover crops becomes especially relevant in terms of the undiscovered potential of absorbing carbon dioxide from atmospheric air.
Keywords: climate changes, global warming, carbon sequestration, sidereal crops, catch crops, greenhouse gases.
The Effect Of Leverage, Independent Commissioners, and Audit Fees On Financial Statement Integrity With Audit Quality As Moderating Variable (Empirical Study on LQ45 Companies Listed on the Indonesia Stock Exchange in 2019 - 2023)
Authors: Pratama Bobby , Adhitama Fardinant , Nurullah Asfeni
Published: February 2025

This research has the main objective to provide special strategies that can be used to increase coffee sales, especially Beanspot. Various data shows that current coffee sales continue to increase, so it is very interesting to research what factors must be met to win the competition. The research method used is descriptive qualitative with data collection through interviews, observation and documentation studies. By carrying out internal analysis consisting of 11 factors and external analysis consisting of 9 factors, the IFAS = 3,349 and EFAS = 3,262 were obtained. In the SWOT diagram, Beanspot is in quadrant III where the most appropriate strategy for Beanspot is stability / turn around or changing tactics. The main suggestion resulting from this research for companies is to focus more on improving the company's internal resources, especially human resources, so that when added to its strengths such as strong networks and competitive prices, Beanspot can dominate the market.
O ensino de Geometria com o uso do Geogebra para o ensino fundamental: contribuições do Estudo de Aula
Authors: Afonso Dieine Jaqueline , Miola Adriana Fatima de Souza
Published: February 2025

This text aims to present an experience in a public school and to discuss the elaboration and execution of an investigative task on Geometry using GeoGebra for elementary school students. The study is part of a master's research and used authors such as Fiorentini, Schön, Pontes, among others. or data production, we used Lesson Study as a research methodology and formed a working group consisting of two researchers and three Mathematics teachers from the partner school. The results revealed that the use of GeoGebra can favor the understanding of the Geometry concepts addressed, and that Lesson Study contributed to the teachers' learning when they share knowledge and experiences with other teachers they interact with in the school environment, enabling reflection and change among the teachers within the school community.
ANÁLISE ESPACIAL E DEMOGRÁFICA DOS CASOS DE DENGUE EM PORTO VELHO, RONDÔNIA: IMPLICAÇÕES PARA POLÍTICAS DE SAÚDE PÚBLICA
Authors: Santos Amanda Marques dos , Souza Rômulo Rodrigues dos Santos , Alvares Oliveira Marcela
Published: February 2025

A dengue é uma arbovirose emergente transmitida principalmente pelo Aedes aegypti, um mosquito da família Culicidae. É uma das doenças infecciosas de maior crescimento global. Este artigo revisa a literatura recente sobre a análise de casos de dengue em Porto Velho, Rondônia, focando em aspectos geográficos, etários e de gênero. A partir de estudos publicados entre 2018 e 2024, examinamos como a segmentação de casos por bairro, idade e gênero pode fornecer insights relevantes para políticas de saúde pública. A revisão revela que a incidência da dengue na cidade está fortemente correlacionada com características socioeconômicas locais e padrões demográficos, o que reforça a necessidade de intervenções direcionadas. A pesquisa destaca a importância de mapear detalhadamente os casos de dengue para planejar campanhas preventivas, otimizar a distribuição de recursos e controlar o vetor Aedes aegypti, visando melhorar as respostas às epidemias. O envolvimento da comunidade é igualmente ressaltado como essencial para uma prevenção eficaz, especialmente entre grupos vulneráveis.
Dengue is an emerging arboviral disease primarily transmitted by Aedes aegypti, a mosquito of the Culicidae family. It is one of the fastest-growing infectious diseases globally. This article reviews recent literature on analyzing dengue cases in Porto Velho, Rondônia, focusing on geographic, age, and gender aspects. Based on studies published between 2018 and 2024, we examine how segmenting cases by neighborhood, age, and gender can provide relevant insights for public health policies. The review reveals that the incidence of dengue in the city is strongly correlated with local socioeconomic characteristics and demographic patterns, reinforcing the need for targeted interventions. The research highlights the importance of detailed mapping of dengue cases to plan preventive campaigns, optimize resource distribution, and control the Aedes aegypti vector, aiming to improve responses to epidemics. Community involvement is also essential for effective prevention, especially among vulnerable groups.
PANORAMA DA SEGURANÇA DO TRABALHO NA CONSTRUÇÃO CIVIL EM JANDAIA DO SUL
Authors: Justi André Luiz , Ferreira Lara , Saizaki Paula Mayumi
Published: February 2025

Este trabalho, intitulado Panorama da Segurança do Trabalho na Construção Civil em Jandaia do Sul, foi escolhido devido ao alto índice de acidentes no setor. O estudo foca na utilização de Equipamentos de Proteção Individual e Coletiva (EPIs e EPCs) no município. O principal problema identificado é a resistência ao cumprimento das normas e a falta de preparo de trabalhadores e líderes em relação à segurança e saúde ocupacional. O Brasil ocupa o quarto lugar mundial em acidentes no setor de construção civil. O objetivo é apresentar como os EPIs são utilizados nas obras de Jandaia do Sul e os acidentes resultantes da negligência. A justificativa é fornecer subsídios para que os trabalhadores tomem decisões conscientes sobre a implementação das Normas Regulamentadoras (NRs) e o uso adequado de equipamentos de segurança, com o intuito de reduzir os acidentes. De acordo com a pesquisa, 72,7% dos trabalhadores sofreram acidentes, e 50% desconhecem as NRs, evidenciando a falta de atenção à segurança no setor.
Can We Raise the Level of Environmental Awareness Through Art?
Authors: Finale Rock
Published: February 2025

In this paper, we underscore the importance of integrating environmental education into the curriculum at all levels of education, especially at the primary level. Teachers are called to adopt innovative didactic approaches, such as Problem-Based Learning, Inquiry-Based Learning, Experiential Learning, and Gestalt pedagogy, to foster environmental consciousness in students. This study presents an experimental investigation conducted in two Slovenian primary schools, involving a sample of 154 fourth-grade students with an average age of 9 years. The research demonstrated that the innovative model of teaching environmental content through visual arts (ECTA) is a new approach that significantly enhanced students' environmental knowledge, awareness, attitudes, and behaviors toward the environment. The experimental group exhibited statistically marked improvements compared to the control group, with higher mean percentages in artworks and more positive ecological attitudes and behaviors. A key research finding was the statistically significant correlation between students' artworks and their environmental awareness, attitudes, and behaviors toward the environment in the experimental group. A strong, statistically significant correlation was found between artwork theme and environmental awareness in the experimental group (r = 0.88, p < 0.001). This correlation was not observed in the control group (r = 0.077, p = 0.503), underscoring the transformative potential of the ECTA approach. By encouraging the creative use of recycled materials and linking artistic expression to ecological topic, this approach provides a holistic learning experience that bridges theoretical knowledge with practical application. The broader adoption of interdisciplinary and innovative teaching models such as ECTA, is necessary to enhance environmental education. It is also important to emphasize the role of fine arts in cultivating ecological responsibility and creative engagement.
Perilaku Komunikasi Siswa SMA-MA Di Daerah Aliran Sungai (Das) Dalam Bermain Esports (Studi Etika Sosial Siswa di Palangka Raya)
Authors: Mikdar U.Z. , Wisman Yossita , Dony Garry William , Bernisa Bernisa
Published: February 2025

Permasalahan penelitian ini adalah terkait dengan perilaku komunikasi siswa dalam bermain ESPORTS  dan  dampaknya  terhadap  kehidupan  sehari-harai  siswa,  sedangkan  tujuannya  adalah untuk mendeskripsikan gambaran perilaku komunikasi siswa dalam bermaain ESPORTS serta dampaknya terhadap perilaku komunikasi dalam kehidupan sehari-hari. Penelitian ini termasuk penelitian kualitatif deskriptif dengan teknik analisis data interaktif Miles dan Huberman. Subyek dan informannya adalah siswa Sekolah Menengah Atas Negeri 10 (SMAN 10), Madrasah Aliyah (MA) Miftahul Jannah, dan Sekolah Menengah Kejuruan (SMK) Al-Ishlah yang berada di Daerah Aliran Sungai (DAS) Palangka Raya, yang berjumlah 30 orang, yang terdiri dari SMAN 10 berjumlah 10 orang, MA 10 orang, dan SMK 10 orang. Dengan beberapa jenis permainan yang dipilih siswa tersebut, seperti Mobile Legends, Free Fire, Genshin Impact, HOK, Roblox, FC Mobile, The Spike, Clash of Clans, CODM, Terraria. Hasil penelitiannya menunjukan bahwa perilaku komunikasi siswa SMA, MA, dan SMK di Daerah Aliran Sungai (DAS) Palangka Raya yang bermain ESPORTS adalah sebagai berikut; (1) terkadang pada saat bermain atau pertandingan keluar kata-kata kasar, teriak- teriak, pukul-pukul meja atau tembok. Bahkan ucapan kata-kata kasar tersebut terkadang terbawa juga  dalam  kehidupan  sehari-hari  walaupun  terbatas  hanya  dengan  teman  akrab  saja;  dan  (2) dampak positifnya bahwa bermain ESPORTS bisa menghilangkan rasa stress, menghilangkan rasa kesepian dan terhibur, sedangkan dampak negatifnya terkadang kurang tidur, emosian, juga mengganggu waktu ibadah.
Preparation and characterization of stearyl glycyrrhetinate/cyclodextrin complex using co-grinding
Authors: Ebisawa Momoko , Kodama Nao , Mitomo Shun-ichi , Tomita Junki , Suzuki Mitsuaki , Inoue Yutaka
Published: February 2025

Aim: In this study, the physicochemical properties of stearyl glycyrrhetinate/β-cyclodextrin (SG/βCD) and SG/γCD complexes were characterized, and the complexes were prepared using the co-milling method. The molecular interactions within the SG/CD complexes were also investigated using nuclear magnetic resonance (NMR) measurements to determine the mode of interaction. Methods: Here, we evaluated the physicochemical properties of SG complexes with CDs prepared by ground mixtures (GM SG/βCD or γCD = 1/1, 1/2). Results: Powder X-ray diffraction (PXRD) showed that the characteristic SG and CD peaks disappeared after co-grinding with GM (SG/CD = molar ratio of 1/2), indicating a halo pattern. Differential scanning calorimetry (DSC) measurements showed that after co-grinding, the endothermic peak due to SG melting, as well as the dehydration peak and the endothermic peak due to SG melting, disappeared. Near-infrared (NIR) spectroscopy results showed that the peaks of SG-derived –CH moieties and CD-derived –OH and –CH moieties broadened in GM, suggesting their involvement in complex formation through SG/CDs intermolecular interactions. In GM (SG/CDs), NMR measurements showed broadened H-A and H-F peaks of the steroid skeleton derived from SG. In GM (SG/βCD = 1/2), the doublet peak, especially OH-3 at the wide edge of CD, shifted to a singlet peak. In GM (SG/γCD = 1/2), the H-3 peak, which is the wide edge of γCD, and the H-6 peak, which is the narrow edge, shifted to broad peaks, suggesting that γCD is deeply encapsulated in the steroidal structure. Conclusions: These findings suggest that complex formation occurred in SG/CDs and that inclusion behavior is different between GM (SG/βCD = 1/2) and GM (SG/γCD = 1/2).
Unlocking the therapeutic potential of protein kinase inhibitors in neurodegenerative and psychiatric disorders
Authors: Asir R V Angela , Buzaeva Polina , Michaelevski Izhak
Published: February 2025

Protein phosphorylation is a fundamental regulatory mechanism governing a broad spectrum of cellular processes. In the nervous system, it is critical for modulating neurotransmitter release, synaptic plasticity, neuronal excitability, and cell survival. Dysregulation of protein kinase activity is closely linked to the pathogenesis of various neurological and psychiatric disorders, positioning several kinases as promising therapeutic targets. Although protein kinase inhibitors (PKIs), a major class of compounds that modulate kinase activity, have shown considerable therapeutic success in oncology, their application in neurological diseases remains in the early stages of exploration. Of the 82 PKIs approved by the Food and Drug Administration (FDA), 37 are now in various preclinical and clinical trials for neurological conditions, primarily targeting signaling pathways mediated by key protein kinases implicated in these diseases. This review examines the roles of critical protein kinases and the therapeutic effects of their inhibitors in neurodegenerative, psychiatric, and selected neurological disorders, such as autism spectrum disorders (ASD) and epilepsy. We focus on Abelson kinase I (ABL1), calmodulin-dependent kinase II (CaMKII), casein kinase 1δ (CK1δ), c-Jun N-terminal kinase (JNK), cyclin-dependent kinase 5 (CDK5), dual-specificity tyrosine-phosphorylated and regulated kinase 1A (DYRK1A), leucine-rich repeat kinase 2 (LRRK2), extracellular signal-regulated kinase 1/2 (ERK1/2), glycogen synthase kinase 3β (GSK3β), mammalian target of rapamycin (mTOR), p38 mitogen-activated protein kinase, and protein kinase C (PKC) in neurodegenerative diseases. Additionally, we discuss CaMKII, CDK5, ERK1/2, PI3K/AKT/GSK3, protein kinase A (PKA), and PKC in psychiatric disorders, focusing on schizophrenia and mood disorders, and analyze GSK3β, ERK1/2, and mTOR in ASD and epilepsy. This review underscores the therapeutic potential of PKIs in neurological disorders while highlighting ongoing challenges and the need for further research to refine kinase-targeted therapies.
A Közbeszerzési Hatóság legfrissebb állásfoglalásai : 2024. májusi összefoglaló
Authors: Rakovitsné Szini Katalin
Published: February 2025

A Közbeszerzési Hatóság állásfoglalások formájában ad felvilágosítást a közbeszerzési eljárásokban résztvevő jogalkalmazók számára a közbeszerzésekről szóló 2015. évi CXLIII. törvény (a továbbiakban: Kbt.) és kapcsolódó végrehajtási rendeleteinek alkalmazásával összefüggő általános jellegű megkeresésekre. Alábbiakban a Kbt. alkalmazásával összefüggő kérdésekre adott válaszainkat rendeztük sorrendbe, bízva abban, hogy iránymutatásaink nem csak a kérdésfeltevőknek, hanem valamennyi Olvasónknak hasznos információkkal szolgálnak. Felhívjuk Tisztelt Olvasóink figyelmét, hogy a közbeszerzésekre irányadó jogszabályok alkalmazásával kapcsolatos döntések meghozatala mindenkor a közbeszerzési eljárások résztvevőinek joga és felelőssége. Hangsúlyozzuk továbbá, hogy az állásfoglalásokban megfogalmazott véleményeknek jogi ereje, kötelező tartalma nincsen.
Jogorvoslati aktualitások : A Döntőbizottság D.302/9/2023. számú határozata
Authors: Horváth Éva
Published: February 2025

A Közbeszerzési Értesítő Plusz jelen számában ismertetett jogesetek a közbeszerzési eljárás megfelelő előkészítésére vonatkozó ajánlatkérői kötelezettségre koncentrálnak. A közbeszerzési eljárások alapos előkészítése biztosítja a megfelelő ajánlatokat, a közbeszerzésre kötelezett ajánlatkérő beszerzési igényének a megvalósítását. A jogorvoslati üggyel érintett tárgyak: Az ajánlatkérő akkor jár el megfelelő alapossággal a közbeszerzési eljárás előkészítése során, ha a szerződésszerű teljesítésre hatással lévő valamennyi esetlegesen felmerülő körülményt számba vesz.
Várható változások a közbeszerzés szabályozásában az európai zöld megállapodáshoz kapcsolódó új és felülvizsgált uniós irányelvek és rendeletek tükrében
Authors: Hubai Ágnes
Published: February 2025

Az Európai Unió az európai zöld megállapodásról szóló közlemény kiadását követően számos irányelvet és rendeletet fogadott el, amelyek közvetlenül vagy közvetve a közbeszerzési eljárásokra is tartalmaznak előírásokat. A cikk ezek közül emel ki hét olyan jogszabályt, amelyeket ugyan csak néhány éven belül kell alkalmazni, de ismeretük hozzájárulhat a jogalkalmazók megfelelő felkészüléséhez.
Gubernatorial elections: predictable results in the regional political context
Authors:   Pyatigorsk State University, Astvatsaturova M. A.
Published: February 2025

The article provides a political analysis of the elections of the governor of the Stavropol Territory held in September 2024. The determinants of the political content and organizational technologies of the election of the head of the region in a broad political-chronological and political-event context are revealed. The initial ambivalent factors of V.V. Vladimirova's career growth as a top official of Stavropol are particularly emphasized. The resource factors of V.V. Vladimirova as the current governor in competition with other candidates are highlighted. The administrative resource is emphasized, as well as other properties of the head of the region in relation to the social needs of the region's population.
Youth labor migration in Uzbekistan
Authors:   Associate Professor of the Department of Social Sciences, Faculty of History, Karakalpak State University named after Berdakh, Uzbekistan, Nesibeli Zaretdinova , Mavluda Khakimniyazova ,   3rd year student of the Sociology department, Faculty of History, Karakalpak State University named after Berdakh, Uzbekistan
Published: February 2025

The process of labor migration in Uzbekistan plays a crucial role in shaping the country’s demographic and economic landscape. This article analyzes the main motives, trends, and consequences of external labor migration from Uzbekistan. In particular, factors contributing to migration - economic problems, shortage of jobs, and the search for better living conditions - are considered. In addition, the social and economic impact of migration, including the experience of returning labor migrants and their contribution to the local economy through remittances, is also analyzed. The study also examines the policies and programs implemented by the Government of Uzbekistan to regulate labor migration.
Formation and development of the military prosecutor's office in Turkestan during the Russian empire period
Authors:   Independent Researcher at the Law Enforcement Academy of the Republic of Uzbekistan, Karimberdiyevich Khudoyberdiyev Bakhodir
Published: February 2025

This article analyzes the formation and development of the prosecutor's office, particularly the military prosecutor's office, in the Turkestan region after its occupation by the Russian Empire. Based on historical sources, it illuminates the activities and functions of this institution.
A brief overview of Colum Mccann’s works and prose style
Authors:   Doctor of Science in Philological Sciences, Professor, Department of English Literary and Translation Studies, Foreign Languages Faculty, Bukhara State University, Uzbekistan, Feruza Khajieva , Shakhnoza Rakhimova ,   MA student of Bukhara State University, Department of English Literary and Translation Studies, Foreign Languages Faculty, Bukhara State University, Uzbekistan
Published: February 2025

Colum McCann is a renowned Irish writer and the author of Let the Great World Spin, TransAtlantic, and Apeirogon. His works explore important themes such as migration, historical memory, social inequality, and human solidarity. McCann masterfully blends reality and fiction, creating poignant and profound stories that resonate with readers worldwide. This article examines his style, key themes, and influence on contemporary literature.
Editorial 2024
Authors: Lorenzatti Marco
Published: February 2025

Editorial
EFFECT OF TRANSCRANIAL DIRECT CURRENT STIMULATION ASSOCIATED WITH PROPRIOCEPTIVE EXERCISES IN CHILDREN AND PRE-ADOLESCENTS WITH ACQUIRED AND CONGENITAL VISUAL IMPAIRMENT: RANDOMIZED CLINICAL TRIAL
Authors: Toledo Roberta Carneiro de , Oliveira Cláudia Santos
Published: February 2025

In the absence of information from the visual system, balance is guided by only two of the three afferent systems. If there is no early stimulation of these systems, blind children tend to become passive, which can have a negative impact on muscle tone, coordination, and balance. The objective of the present study was to analyze whether transcranial direct current stimulation (tDCS) is capable of enhancing the effects of static and dynamic proprioceptive exercises on gait and balance control in children and pre-adolescents with acquired or congenital visual impairment. The study will be conducted after approval by the Research Ethics Committee of the Evangelical University of Anápolis, Anápolis, GO, Brazil (certificate number: 4610052.6.0000.5076). The study will be divided into three phases. Phase 1 will be a cross-sectional study for the characterization of gait, postural control, and balance (static and dynamic) in the sample. Phase 2 will be a pilot study that will serve to determine the sample size for Phase 3. Both phases 2 and 3 will employ the same methods and will constitute a randomized, controlled, double-blind clinical trial. The participants will be randomly divided into four groups: G1) Active TENS + static proprioceptive exercises; G2) simulated TENS + static proprioceptive exercises; G3) active TENS + dynamic proprioceptive exercises; G4-sham TENS + dynamic proprioceptive exercises. The results will be based on evaluations conducted at three time points (pre-intervention, post-intervention [after ten treatment sessions], and one-month follow-up) and will involve three-dimensional gait analysis, as well as assessments of functional mobility and balance (static and dynamic).
THE ENVIRONMENTAL HEALTH OF THE GOIÁS JUDICIARY SERVERS: ADVANCES AND PERSPECTIVES BASED ON DATA FROM THE MUNICIPALITY OF LUZIÂNIA-GO
Authors: Santos Edmilson Jardim dos , Rosseto Lucimar Pinheiro , Maranhão Mariana
Published: February 2025

In this study, a considerable rate of absenteeism due to illness was evidenced among the employees of the Luziânia District - GO. The importance of health for the proper functioning of the Goian Judiciary is highlighted, as the lack of adequate care negatively affects the performance of their work activities. The research highlights the relevance of constitutional regulations, such as fundamental rights and the right to health, and also emphasizes the need for care regarding health-related changes, especially those related to modernization, and their impact on the employees. The results indicate the need to improve health care for public servants, with a focus on mental health, taking into account environmental, social, and technological factors. This research paves the way for broader investigations on how the management of the Judiciary can ensure the quality of life of its employees in accordance with the fundamental right to health.
Métodos de alfabetização: um estudo de caso em uma escola da rede pública municipal de Barra do Garças-MT
Authors: Lima Hanna Lorrane , Mota Elenice da Silva , Santana Isis Terezinha Santos de , Amorim Jhonata Jankowitsch
Published: February 2025

Introdução: Este estudo examina diferentes métodos de alfabetização, de modo a explorar suas peculiaridades e impactos no desenvolvimento da leitura e escrita. Nessa perspectiva, vale considerar que a escolha adequada do método de ensino é fundamental para o sucesso da aprendizagem e a compreensão leitora dos alunos. Objetivo: Investigar a aplicação de métodos de alfabetização, com ênfase na análise de abordagens eficazes para promover o desenvolvimento das habilidades de leitura e escrita dos alunos. Método: A pesquisa teve uma abordagem quali-quantitativa, uma vez que o questionário propiciou a aquisição de dados das duas naturezas, com questões de múltipla escolha e discursivas. Foram realizadas consultas bibliográficas em livros e artigos científicos, que não se restringiram apenas aos métodos de alfabetização, mas envolveram discussões acerca do letramento. Por meio da pesquisa exploratória, buscou-se familiarizar com o assunto e a partir da observação em sala de aula, descreveu-se os resultados. Resultados: Constatou-se que o método de consciência fonológica foi amplamente adotado e demonstrou resultados positivos, com aumento significativo no desempenho dos alunos em termos de alfabetização. Conclusões: A pesquisa destacou a importância de se utilizar métodos que integrem tanto a fonética quanto atividades lúdicas para maximizar o desenvolvimento da leitura e escrita.
Donatello’s Genesis reliefs of c. 1405: adapting a Roman statuette in Ghiberti’s collection
Authors: Spicer Joaneath
Published: February 2025

The four extant (out of the original six) terracotta reliefs with the early history of Adam and Eve (Victoria & Albert Museum, London, and Museo dell’Opera del Duomo, Florence) are here argued to be certainly by Donatello, to be for gilded companion marriage chests, commissioned by a member of the Corsini family, and among the artist’s earliest known works, datable to around 1405 when he was in Lorenzo Ghiberti’s workshop. Their most intriguing feature is the brilliant, subtle adaptation for one figure of a small Roman bronze of Victoria Romana in Ghiberti’s collection. This is made more consequential as Victory’s figural type is directly based on Nike, the Greek personification of victory, so Donatello unknowingly introduced a Greek figure type into the Italian Renaissance, a figure type that then worked its way through the artist’s later art and indeed that of the Italian Renaissance. On a further plane, it is the previously unrecognized Renaissance point of entry of Aby Warburg’s ‘Florentine nymph’.
The Effects of the Carbon-to-oxygen Ratio on the Condensate Compositions around Solar-like Stars
Authors: Shakespeare Cody J. , Li Min , Huang Shichun , Zhu Zhaohuan , Steffen Jason H.
Published: February 2025

The initial stellar carbon-to-oxygen (C/O) ratio can have a large impact on the resulting condensed species present in the protoplanetary disk and, hence, the composition of the bodies and planets that form. The observed C/Os of stars can vary from 0.1–1. We use a sequential dust condensation model to examine the impact of the C/O on the composition of solids around a solar-like star. We utilize this model in a focused examination of the impact of varying the initial stellar C/O to isolate the effects of the C/O in the context of solar-like stars. We describe three different system types in our findings. The solar system falls into the silicate-dominant, low-C/O systems which end at a stellar C/O somewhere between 0.52 and 0.6. At C/Os between about 0.6 and 0.9, we have intermediate systems. Intermediate systems show a decrease in silicates while carbides begin to become significant. Carbide-dominant systems begin around a C/O of 0.9. Carbide-dominant systems exhibit high carbide surface densities at inner radii with comparable levels of carbides and silicates at outer radii. Our models show that changes between C/O = 0.8 and C/O = 1 are more significant than previous studies, that carbon can exceed 80% of the condensed mass, and that carbon condensation can be significant at radii up to 6 au.
The Formation Histories of Massive and Quiescent Galaxies in the 3 < z < 4.5 Universe
Authors: Nanayakkara Themiya , Glazebrook Karl , Schreiber Corentin , Chittenden Harry , Brammer Gabriel , Esdaile James , Jacobs Colin , Kacprzak Glenn G. , Kawinwanichakij Lalitwadee , Kimmig Lucas C. , Labbe Ivo , Lagos Claudia , Marchesini Danilo , Martìnez-Marìn M. , Marsan Z. Cemile , Oesch Pascal A. , Papovich Casey , Remus Rhea-Silvia , Tran Kim-Vy H.
Published: February 2025

We present the formation histories of 19 massive (≳3 × 1010
M
⊙) quiescent (specific star formation rate, sSFR < 0.15 Gyr−1) galaxy candidates at z ~ 3.0–4.5 observed using JWST/NIRSpec. This completes the spectroscopic confirmation of the 24 K-selected quiescent galaxy sample from the ZFOURGE and 3DHST surveys. Utilizing Prism 1–5 μm spectroscopy, we confirm that all 12 sources that eluded confirmation by ground-based spectroscopy lie at z > 3, resulting in a spectroscopically confirmed number density of ~1.4 × 10−5 Mpc−3 between z ~ 3 and 4. Rest-frame U − V versus V − J color selections show high effectiveness in identifying quiescent galaxies, with a purity of ~90%. Our analysis shows that parametric star formation histories (SFHs) from FAST++ and binned SFHs from Prospector on average yield consistent results, revealing diverse formation and quenching times. The oldest galaxy formed ~6 × 1010
M
⊙ by z ~ 10 and has been quiescent for over 1 Gyr at z ~ 3.2. We detect two galaxies with ongoing star formation and six with active galactic nuclei (AGNs). We demonstrate that the choice of stellar population models, stellar libraries, and nebular or AGN contributions does not significantly affect the derived average SFHs of the galaxies. We demonstrate that extending spectral fitting beyond the rest-frame optical regime reduces the inferred average star formation rates (SFRs) in the earliest time bins of the SFH reconstruction. The assumed SFH prior influences the SFR at early times, where spectral diagnostic power is limited. Simulated z ~ 3 quiescent galaxies from IllustrisTNG, SHARK, and Magneticum broadly match the average SFHs of the observed sample but struggle to capture the full diversity, particularly at early stages. Our results emphasize the need for mechanisms that rapidly build stellar mass and quench star formation within the first billion years of the Universe.
Kite-borne Spectroscopic Observations of the Corona During the 2023 April 20 Total Solar Eclipse
Authors: Justen Benedikt , Habbal Shadia Rifai , Justen Matthias , Mayer Oliver , Ding Adalbert , Brumann Klemens , Stehr Herbert
Published: February 2025

We report in this Letter on the first use of a kite as an airborne platform for coronal observations during total solar eclipses, to mitigate the detrimental impact of clouds when present. In this first innovative attempt, the scientific payload was chosen to be a single-channel color spectrometer operating in high order over the wavelength range of 400–1000 nm, with light being fed from a coelostat that tracked the Sun optically. The payload was made airborne by a Cody-box-type kite with a wingspan of 6.5 m and launched from Cape Range National Park in North West Australia during the 2023 April 20 total solar eclipse. The kite and payload reached a terminal altitude of 450 m about 30 minutes prior to second contact and remained airborne 1 hr past the 58 s of totality. Although the tracking was not perfect, it nevertheless enabled the acquisition of two coronal spectra. This first successful technology demonstration paves the way for the feasibility of future low-cost kite-borne payloads for astronomical observations not limited to total solar eclipses.
On the morphological variability of Hister shanghaicus Marseul, 1861 (Coleoptera: Histeridae)
Authors: Zheng Ji-Huan , Lackner Tomáš
Published: February 2025

In Histerid identification and morphological studies alike, the configuration of dorsal elytral striae has been a widely used important characteristic. The variability of dorsal elytral striae in Hister shanghaicus Marseul, 1861 has been observed when examining multiple specimens collected from Gutian Natural Server (Guangdong Province) and Jiulianshan Natural Server (Jiangxi Province), southern China. The species is herein for the first time reported from the Jiangxi Province (southern China).
A collection of field-based indicators for assessing ecosystem services in crop fields
Authors: Leveau Lola , Biot Nicolas , Lobet Guillaume , Bertin Pierre
Published: February 2025

The transition from intensive crop production to more sustainable practices, such as ecologically intensive cropping systems, requires precise, field-based assessments of Ecosystem Services (ES). These assessments depend on selecting appropriate indicators that can measure the supply of ES directly within crop fields. Despite the growing recognition of ES role in sustainable agriculture, comprehensive lists of field-applicable indicators remain scarce. To address this gap, we present a collection of indicators for assessing ES in cropping systems, specifically designed for in situ measurements. The collection aims to support researchers and practitioners in selecting context-specific indicators that enhance site-specific knowledge for developing sustainable cropping systems. It was derived from the exhaustive list provided by Boerema et al. (2016), which included 507 indicators applicable across various ecosystem types and linked to various data collection methods. It covers provisioning and regulating ES, emphasizing empirical data collection methods such as field observations and remote sensing. Our analysis highlights significant disparities in indicator distribution across ES, cascade levels, and measurement methods, with a predominance of indicators for soil quality regulation and pollination ES. We also identify gaps in field-based assessments, particularly for air quality regulation, life cycle maintenance and water provision. Finally, we underscore the importance of staying alert to emerging indicators driven by recent research trends and technological advancements, such as remote sensing.
Revision of the Trichoclinocera systenognatha species subgroup from eastern Asia (Diptera, Empididae, Clinocerinae)
Authors: Saigusa Toyohei , Sinclair Bradley J.
Published: February 2025

The Trichoclinocera systenognatha species subgroup from eastern Asia is newly recognized on the basis of the long triangular projection from the ventral margin of the labellum and includes three new species, which are described here: T. elongatasp. nov., T. subelongatasp. nov. and T. systenognathasp. nov. An identification key to species is provided and their distributions mapped.
Extending the fossil record of Miocene neotropical epiphyte communities
Authors: Feldberg Kathrin , Kaasalainen Ulla , Mamontov Yuriy S. , Gradstein S. Robbert , Schäfer-Verwimp Alfons , Divakar Pradeep K. , Schmidt Alexander R.
Published: February 2025

Dominican amber (15–20 Ma) and Mexican amber (15–23 Ma) are valuable sources of fossil epiphytic bryophytes, ferns, and lichens. Both ambers derive from resins of Hymenaea, a genus in the Fabaceae family still occurring in Mexico, Central America, and the Caribbean today. The amber inclusions provide rare glimpses into Miocene neotropical epiphyte communities in life-like preservation. In this study, we extend the fossil record of these communities and describe Frullania chiapasensis and Thysananthus patrickmuelleri, two new fossil species of leafy liverworts from Mexican amber. Frullania chiapasensis is the fourth representative of this genus from tropical amber. The genus Thysananthus is rather diverse in Dominican amber, and it is here newly recorded from Mexican amber. Additionally, we treat five new fossils at genus level, including one leafy liverwort (Lejeunea sp.) as well as three lichens from Dominican amber and one lichen from Mexican amber, all belonging to the extant genus Parmotrema. All four cryptogamic genera are common extant elements of tropical and subtropical forests. The new fossil evidence substantiates that Miocene neotropical cryptogamic communities were very similar to extant ones at generic level.