bluuebunny/crossref_metadata_2025 huggingface dataset:
An Analytical–Numerical Model for Determining “Drill String–Wellbore” Frictional Interaction Forces
Authors: Bembenek Michał , Grydzhuk Yaroslav , Gajdzik Bożena , Ropyak Liubomyr , Pashechko Mykhaylo , Slabyi Orest , Al-Tanakchi Ahmed , Pryhorovska Tetiana
Published: January 2024

Currently, drilling of directional oil and gas wells under complex technical-technological and mining-geological conditions requires the use of drill pipes made of various materials. In turn, to choose rational modes of strengthening drill pipes and drill string layouts, information on the contact forces and friction forces of the drill string pipes on boreholes is necessary. Drill pipe curved sections friction with boreholes and drill bit resistance moment changes are the main causes of uneven rotation of a drill string during rotary or combined drilling methods and the occurrence of parametric oscillations. To reduce the cost of mechanical energy for well wiring, it is necessary to take into account the “drill string–borehole rocks” force interaction to estimate the magnitude of the frictional forces and their influence on the technological parameters of the drilling process. To solve this problem, mathematical models of “conventionally vertical and inclined drill string sections–borehole” were built. Based on the industrial data, an analysis of the force interaction of a deformed drill string composed of pipes made of different materials (aluminum, titanium, steel) was carried out. Analytical dependences were obtained for determining the contact forces and friction of the pipes on boreholes. A numerical study of the change of these power factors depending on the depth of the well under conditions of intensive vibration loading was carried out. The amplitude values of these forces, the frequency of their change for good sections, as well as the places for the most rational installation of drill pipes in the layout of the drill string were estimated. It was established that the intensity of contact and friction forces for steel drill pipes is greater than for titanium or aluminum ones. It is shown that the greater impact of a solid steel string on contact forces and frictional forces compared to a layout with sections of titanium or aluminum pipes in the range of vibration frequencies of 8–22 Hz corresponds to a bit rotation frequency of 70–80 rpm. The practical application of the obtained research results will contribute to the improvement of technical and economic indicators of the well drilling process.
Calculation Methods of High-Voltage Direct Current (HVDC) Line Sag Considering Meteorology
Authors: Li Xin , Xie Zuibing , Zeng Linping , Zhao Long
Published: January 2024

Sag is one of the important indicators for judging whether a transmission line is safe. The existing sag calculation method does not consider the temperature difference between conductor strands, causing the calculated results to often deviate from the values measured with a theodolite. In this article, a sag calculation method considering the temperature difference between strands is proposed. First, finite element analysis and experiments were used to analyze the temperature differences between each area and layer of the conductor when the wind blew the conductor, and then a correction calculation model for the conductor sag was proposed. Next, a sag monitoring system based on four-point temperature measurement was designed. Finally, the method was applied to a ±400 kV transmission line in Qinghai Province, China. The results show that after considering the temperature difference in the conductor strands, the error of the sag calculation result is much smaller than that without considering the temperature difference in the conductor strands, and the maximum relative error is reduced from 7.86% to less than 2%.
Quantifying the Impact of Street Greening during Full-Leaf Seasons on Emotional Perception: Guidelines for Resident Well-Being
Authors: Hao Nayi , Li Xinzhou , Han Danping , Nie Wenbin
Published: January 2024

Quantifying the emotional impact of street greening during the full-leaf seasons in spring, summer, and fall is important for well-being-focused urban construction. Current emotional perception models usually focus on the influence of objects identified through semantic segmentation of street view images and lack explanation. Therefore, interpretability models that quantify street greening’s emotional effects are needed. This study aims to measure and explain the influence of street greening on emotions to help urban planners make decisions. This would improve the living environment, foster positive emotions, and help residents recover from negative emotions. In Hangzhou, China, we used the Baidu Map API to obtain street view images when plants were in the full-leaf state. Semantic segmentation was used to separate plant parts from street view images, enabling the calculation of the Green View Index, Plant Level Diversity, Plant Color Richness, and Tree–Sky View Factor. We created a dataset specifically designed for the purpose of emotional perception, including four distinct categories: pleasure, relaxation, boredom, and anxiety. This dataset was generated through a combination of machine learning algorithms and human evaluation. Scores range from 1 to 5, with higher values indicating stronger emotions and lower values indicating less intense ones. The random forest model and Shapley Additive Explanation (SHAP) algorithm were employed to identify the key indicators that affect emotions. Emotions were most affected by the Plant Level Diversity and Green View Index. These indicators and emotions have an intricate non-linear relationship. Specifically, a higher Green View Index (often indicating the presence of 20–35 fully grown trees within a 200 m range in street view images) and a greater Plant Level Diversity significantly promoted positive emotional responses. Our study provided local planning departments with support for well-being-focused urban planning and renewal decisions. Based on our research, we recommend the following actions: (1) increase the amount of visible green in areas with a low Green View Index; (2) plant seasonal and flowering plants like camellia, ginkgo, and goldenrain trees to enhance the diversity and colors; (3) trim plants in areas with low safety perception to improve visibility; (4) introduce evergreen plants like cinnamomum camphor, osmanthus, and pine.
Soil Properties and Forest Decline in the North-Western Part of Romania
Authors: Onet Aurelia , Vidican Roxana , Ghergheles Carmen , Corcoz Larisa , Stoian Vlad , Onet Cristian , Teusdea Alin Cristian
Published: January 2024

The paper presents the study of the soil quality and health expressed by the chemical and biological properties in a research field placed at Varciorog, Bihor County, Romania. The soil samples were collected from 3 soil variants in March 2023. In each soil variant, some soil chemical parameters and the abundance of bacteria were determined. The frequency and intensity of colonization, along with arbuscules and vesicles, were scored to determine the mycorrhizal potential of each soil. The community-level physiological profile was used to determine the functional microbiome and its ability to decompose a specific set of substrates. In the control variant (CTRL), which is a functional forest cultivated with beech in a proportion of 90%, the soil properties were compared with those determined from Site 1 (a declined mixed forest) and from Site 2 (chestnut forest in a stage of complete drying). The data were statistically processed with a one-way ANOVA test, followed by the Duncan post-hoc test, which revealed significant variation in the potential of microbial functional communities across the analyzed sites. Also, the soil parameters that significantly varied in the 3 soil variants were bacterial number, pH, humus, exchangeable aluminum, coarse sand, dust, and fine sand. The Pearson correlation was computed to study the links between bacterial numbers and chemical parameters. The results showed strong correlations between most of the studied soil properties. The Ecoplates approach to soil functional microbiome highlighted various differences between the microbial communities of the three tested sites. Mycorrhizal colonization shows different potentials for symbiosis formation. The peak of mycorrhizal colonization was in declined forest, with 43.36% colonization frequency and 24.56% intensity. Arbuscules reached 11.36% in declined forest, while in control and decayed sites, the indicator was under 4%. Vesicles are more associated with control and decayed forests, with values of presence over 1.30%. As an indicator of microbial general activity, the sum of recorded activities was higher in declined and decayed forests. At these sites, the activity of the functional microbiome was amplified. The decline process activates a higher diversity of functional groups and is associated with a larger area of substrate decomposition capacity, which indicates a more extensive range of microbial functions related to breaking down organic matter.
Impact of High-Moisture Ear Corn on Antioxidant Capacity, Immunity, Rumen Fermentation, and Microbial Diversity in Pluriparous Dairy Cows
Authors: Shang Songlin , Li Jiajun , Zhang Wenjing , Zhang Xinrui , Bai Jinni , Yang Zhiye , Wang Xiangguo , Fortina Riccardo , Gasco Laura , Guo Kaijun
Published: January 2024

Due to the increasing costs of livestock farming, it is important to find cost-effective alternatives of feed stuffs. This study investigated the effects of high-moisture ear corn (HMEC) feeding on the production performance, serum antioxidant capacity, immunity, and ruminal fermentation and microbiome of dairy cows. Thirty pluriparous Chinese Holstein cows were randomly allocated to two groups: steam-flaked corn (SFC) and HMEC (replacement of 2 kg equal dry matter SFC) and fed for a 60 day trial. The results showed replacing SFC with HMEC significantly increased dry matter intake, milk yield, and 4% fat-corrected milk yield (p < 0.05). Serum levels of superoxide dismutase, glutathione peroxidase, and immunoglobulins G, M, and A were significantly higher, and those of creatinine and cholesterol were significantly lower, in the HMEC group than in the SFC group (p < 0.05). HMEC also significantly increased total volatile fatty acid and acetate (p < 0.05) concentrations. In both groups, the dominant phyla of ruminal bacteria were Bacteroidetes, Firmicutes, and Actinobacteria, and the dominant genera were Prevotella, NK4A214-group, and Succiniclasticum. Mogibacterium, Eubacterium nodatum group, norank-f-Lachnospiraceae, and Eubacterium brachy group were significantly enriched in the ruminal fluid of HMEC-group cows (p < 0.05). In conclusion, replacing SFC with HMEC improved production performance, antioxidant capacity, and immunity, while regulating both ruminal fermentation and the composition of the ruminal microbiome in dairy cows.
A Comprehensive Study and Analysis of the Third Generation Partnership Project’s 5G New Radio for Vehicle-to-Everything Communication
Authors: Ali G. G. Md. Nawaz , Sadat Mohammad Nazmus , Miah Md Suruz , Sharief Sameer Ahmed , Wang Yun
Published: January 2024

Recently, the Third Generation Partnership Project (3GPP) introduced new radio (NR) technology for vehicle-to-everything (V2X) communication to enable delay-sensitive and bandwidth-hungry applications in vehicular communication. The NR system is strategically crafted to complement the existing long-term evolution (LTE) cellular-vehicle-to-everything (C-V2X) infrastructure, particularly to support advanced services such as the operation of automated vehicles. It is widely anticipated that the fifth-generation (5G) NR system will surpass LTE C-V2X in terms of achieving superior performance in scenarios characterized by high throughput, low latency, and enhanced reliability, especially in the context of congested traffic conditions and a diverse range of vehicular applications. This article will provide a comprehensive literature review on vehicular communications from dedicated short-range communication (DSRC) to NR V2X. Subsequently, it delves into a detailed examination of the challenges and opportunities inherent in NR V2X technology. Finally, we proceed to elucidate the process of creating and analyzing an open-source 5G NR V2X module in network simulation-3 (ns-3) and then demonstrate the NR V2X performance in terms of different key performance indicators implemented through diverse operational scenarios.
A Novel Semantic IoT Middleware for Secure Data Management: Blockchain and AI-Driven Context Awareness
Authors: Elkhodr Mahmoud , Khan Samiya , Gide Ergun
Published: January 2024

In the modern digital landscape of the Internet of Things (IoT), data interoperability and heterogeneity present critical challenges, particularly with the increasing complexity of IoT systems and networks. Addressing these challenges, while ensuring data security and user trust, is pivotal. This paper proposes a novel Semantic IoT Middleware (SIM) for healthcare. The architecture of this middleware comprises the following main processes: data generation, semantic annotation, security encryption, and semantic operations. The data generation module facilitates seamless data and event sourcing, while the Semantic Annotation Component assigns structured vocabulary for uniformity. SIM adopts blockchain technology to provide enhanced data security, and its layered approach ensures robust interoperability and intuitive user-centric operations for IoT systems. The security encryption module offers data protection, and the semantic operations module underpins data processing and integration. A distinctive feature of this middleware is its proficiency in service integration, leveraging semantic descriptions augmented by user feedback. Additionally, SIM integrates artificial intelligence (AI) feedback mechanisms to continuously refine and optimise the middleware’s operational efficiency.
Novel Therapeutic Hybrid Systems Using Hydrogels and Nanotechnology: A Focus on Nanoemulgels for the Treatment of Skin Diseases
Authors: Sghier Kamil , Mur Maja , Veiga Francisco , Paiva-Santos Ana Cláudia , Pires Patrícia C.
Published: January 2024

Topical and transdermal drug delivery are advantageous administration routes, especially when treating diseases and conditions with a skin etiology. Nevertheless, conventional dosage forms often lead to low therapeutic efficacy, safety issues, and patient noncompliance. To tackle these issues, novel topical and transdermal platforms involving nanotechnology have been developed. This review focuses on the latest advances regarding the development of nanoemulgels for skin application, encapsulating a wide variety of molecules, including already marketed drugs (miconazole, ketoconazole, fusidic acid, imiquimod, meloxicam), repurposed marketed drugs (atorvastatin, omeprazole, leflunomide), natural-derived compounds (eucalyptol, naringenin, thymoquinone, curcumin, chrysin, brucine, capsaicin), and other synthetic molecules (ebselen, tocotrienols, retinyl palmitate), for wound healing, skin and skin appendage infections, skin inflammatory diseases, skin cancer, neuropathy, or anti-aging purposes. Developed formulations revealed adequate droplet size, PDI, viscosity, spreadability, pH, stability, drug release, and drug permeation and/or retention capacity, having more advantageous characteristics than current marketed formulations. In vitro and/or in vivo studies established the safety and efficacy of the developed formulations, confirming their therapeutic potential, and making them promising platforms for the replacement of current therapies, or as possible adjuvant treatments, which might someday effectively reach the market to help fight highly incident skin or systemic diseases and conditions.
Therapeutic Applications of Extracellular Vesicles in Inflammatory Bowel Disease
Authors: Kim Sang Hyun , Keum Bora , Kwak Sooun , Byun Junhyoung , Shin Jae Min , Kim Tae Hoon
Published: January 2024

The treatment landscape for inflammatory bowel disease (IBD) has undergone substantial advancements with the introduction of biologics. However, a considerable number of patients either show an immediate lack of response or lose responsiveness over time, necessitating the development of innovative and effective treatment approaches. Extracellular vesicles (EVs) are small lipid bilayer-enclosed structures that facilitate cell-to-cell molecular transfer and are integral to the pathogenesis of IBD. They play pivotal roles in maintaining the integrity of the intestinal epithelial barrier and the expulsion of cellular metabolites. The potential use of EVs as drug carriers or therapeutic agents has opened up a plethora of clinical applications. This review investigates the creation and content of EVs, their role in IBD development, and advances in their isolation and analytical techniques. Furthermore, the therapeutic promise they hold for IBD is explored, along with the latest research on their roles as IBD drug delivery systems.
Efficient Revocable Attribute-Based Encryption with Data Integrity and Key Escrow-Free
Authors: Huang Meijuan , Liu Yutian , Yang Bo , Zhao Yanqi , Zhang Mingrui
Published: January 2024

Revocable attribute-based encryption (RABE) provides greater flexibility and fine-grained access control for data sharing. However, the revocation process for most RABE schemes today is performed by the cloud storage provider (CSP). Since the CSP is an honest and curious third party, there is no guarantee that the plaintext data corresponding to the new ciphertext after revocation is the same as the original plaintext data. In addition, most attribute-based encryption schemes suffer from issues related to key escrow. To overcome the aforementioned issues, we present an efficient RABE scheme that supports data integrity while also addressing the key escrow issue. We demonstrate the security for our system, which is reduced to the decisional q-parallel bilinear Diffie-Hellman exponent (q-PBDHE) assumption and discrete logarithm (DL) assumption. The performance analysis illustrates that our scheme is efficient.
Host-Encoded Aminotransferase Import into the Endosymbiotic Bacteria Nardonella of Red Palm Weevil
Authors: Huang Ying , Feng Zhen-Feng , Li Fan , Hou You-Ming
Published: January 2024

Symbiotic systems are intimately integrated at multiple levels. Host–endosymbiont metabolic complementarity in amino acid biosynthesis is especially important for sap-feeding insects and their symbionts. In weevil–Nardonella endosymbiosis, the final step reaction of the endosymbiont tyrosine synthesis pathway is complemented by host-encoded aminotransferases. Based on previous results from other insects, we suspected that these aminotransferases were likely transported into the Nardonella cytoplasm to produce tyrosine. Here, we identified five aminotransferase genes in the genome of the red palm weevil. Using quantitative real-time RT-PCR, we confirmed that RfGOT1 and RfGOT2A were specifically expressed in the bacteriome. RNA interference targeting these two aminotransferase genes reduced the tyrosine level in the bacteriome. The immunofluorescence-FISH double labeling localization analysis revealed that RfGOT1 and RfGOT2A were present within the bacteriocyte, where they colocalized with Nardonella cells. Immunogold transmission electron microscopy demonstrated the localization of RfGOT1 and RfGOT2A in the cytosol of Nardonella and the bacteriocyte. Our data revealed that RfGOT1 and RfGOT2A are transported into the Nardonella cytoplasm to collaborate with genes retained in the Nardonella genome in order to synthesize tyrosine. The results of our study will enhance the understanding of the integration of host and endosymbiont metabolism in amino acid biosynthesis.
A Survey of the Dung-Dwelling Arthropod Community in the Pastures of the Northern Plains
Authors: Schmid Ryan B. , Welch Kelton D. , Lundgren Jonathan G.
Published: January 2024

Grassland ecosystems of the Northern Plains have changed substantially since European settlement began in the latter half of the 19th century. This has led to significant changes to the dung-dwelling arthropod community in the region. As humans continue to modify large portions of the landscape, inventories of ecologically significant communities are important to collect in order to monitor the long-term effects of anthropogenic biomes. We conducted a survey of the arthropod community dwelling in cattle dung from 40 pastures extending from northeast South Dakota to central North Dakota during the 2019 and 2020 grazing seasons. In sum, 51,283 specimens were collected from 596 dung pats, comprising a community of 22 orders. Coleoptera, Diptera, and Hymenoptera contributed to the majority (94.5%) of the community abundance. The mean pest abundance was low per pat (0.43 adult pests/pat), with 80% of the pats not containing any adult pest. Ecologically beneficial dung-feeding beetles, predators, and parasitoids were abundant in the region, but it was an inconsistent community, which may hinder ecosystem services. This highlights the need for future work to understand the mechanisms to increase the consistency of dung pat colonization for improved consistency of ecosystem services in the region.
SA-β-Gal in Kidney Tubules as a Predictor of Renal Outcome in Patients with Chronic Kidney Disease
Authors: Esposito Pasquale , Picciotto Daniela , Verzola Daniela , Garibotto Giacomo , Parodi Emanuele Luigi , Sofia Antonella , Costigliolo Francesca , Gaggero Gabriele , Zanetti Valentina , Saio Michela , Viazzi Francesca
Published: January 2024

Cellular senescence has emerged as an important driver of aging and age-related disease in the kidney. The activity of β-galactosidase at pH 6 (SA-β-Gal) is a classic maker of senescence in cellular biology; however, the predictive role of kidney tissue SA-β-Gal on eGFR loss in chronic kidney disease (CKD) is still not understood. We retrospectively studied the expression of SA-β-Gal in kidney biopsies obtained in a cohort [n = 22] of incident patients who were followed up for 3 years as standard of care. SA-β-Gal staining was approximately fourfold higher in the tubular compartment of patients with CKD vs. controls [26.0 ± 9 vs. 7.4 ± 6% positive tubuli in patients vs. controls; p < 0.025]. Tubular expressions of SA-β-Gal, but not proteinuria, at the time of biopsy correlated with eGFR loss at the follow up; moreover, SA-β-Gal expression in more than 30% of kidney tubules was associated with fast progressive kidney disease. In conclusion, our study shows that SA-β-Gal is upregulated in the kidney tubular compartment of adult patients affected by CKD and suggests that tubular SA-β-Gal is associated with accelerated loss of renal function.
Advancing Research and Treatment: An Overview of Clinical Trials in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Future Perspectives
Authors: Seton Katharine A. , Espejo-Oltra José A. , Giménez-Orenga Karen , Haagmans Rik , Ramadan Donia J. , Mehlsen Jesper
Published: January 2024

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic, debilitating, and multi-faceted illness. Heterogenous onset and clinical presentation with additional comorbidities make it difficult to diagnose, characterize, and successfully treat. Current treatment guidelines focus on symptom management, but with no clear target or causative mechanism, remission rates are low, and fewer than 5% of patients return to their pre-morbid activity levels. Therefore, there is an urgent need to undertake robust clinical trials to identify effective treatments. This review synthesizes insights from clinical trials exploring pharmacological interventions and dietary supplements targeting immunological, metabolic, gastrointestinal, neurological, and neuroendocrine dysfunction in ME/CFS patients which require further exploration. Additionally, the trialling of alternative interventions in ME/CFS based on reported efficacy in the treatment of illnesses with overlapping symptomology is also discussed. Finally, we provide important considerations and make recommendations, focusing on outcome measures, to ensure the execution of future high-quality clinical trials to establish clinical efficacy of evidence-based interventions that are needed for adoption in clinical practice.
Assessment of Cement Leakage in Decompressed Percutaneous Kyphoplasty
Authors: Cheng Shih-Hao , Chou Wen-Hsiang , Tsuei Yu-Chuan , Chu William , Chu Woei-Chyn
Published: January 2024

Symptomatic osteoporotic compression fractures are commonly addressed through vertebroplasty and kyphoplasty. However, cement leakage poses a significant risk of neurological damage. We introduced “aspiration percutaneous kyphoplasty”, also known as “decompressed kyphoplasty”, as a method to mitigate cement leakage and conducted a comparative analysis with high viscosity cement vertebroplasty. We conducted a retrospective study that included 136 patients with single-level osteoporotic compression fractures. Among them, 70 patients underwent high viscosity cement vertebroplasty, while 66 patients received decompressed percutaneous kyphoplasty with low-viscosity cement. Comparison parameters included cement leakage rates, kyphotic angle alterations, and the occurrence of adjacent segment fractures. The overall cement leakage rate favored the decompressed kyphoplasty group (9.1% vs. 18.6%), although statistical significance was not achieved (p = 0.111). Nonetheless, the risk of intradiscal leakage significantly reduced in the decompressed kyphoplasty cohort (p = 0.011), which was particularly evident in cases lacking the preoperative cleft sign on X-rays. Kyphotic angle changes and the risk of adjacent segment collapse exhibited similar outcomes (p = 0.739 and 0.522, respectively). We concluded that decompressed kyphoplasty demonstrates efficacy in reducing intradiscal cement leakage, particularly benefiting patients without the preoperative cleft sign on X-rays by preventing intradiscal leakage.
Lung Involvement in Patients with Ulcerative Colitis: Relationship between Exhaled Nitric Oxide and Lung Function
Authors: Ragnoli Beatrice , Cena Tiziana , Pochetti Patrizia , Pignatti Patrizia , Malerba Mario
Published: January 2024

Ulcerative colitis (UC) is characterized by immune system dysregulation with frequent extraintestinal manifestations, including airway involvement. A reduction in CO diffusing capacity and functional alterations in small airways have been described. An extended analysis of fractional exhaled nitric oxide (FeNO) may distinguish the sites of production, and the presence of small airway inflammation may be a useful, non-invasive marker for patient follow-up. The aim of our study was to compare the PFTs as well as FeNO and CANO values of UC patients with different clinical disease activities and healthy subjects to reveal lung function abnormalities and the presence of subclinical airway inflammation. We enrolled 42 adult outpatients at different clinical activity stages of UC (39 ± 13 years) and a healthy control group of 41 subjects (29 ± 3 years). C-reactive protein (CRP) and FeNO values at different flows (50,100, and 200 mL/s) were collected. All patients performed pulmonary function tests (PFTs) with static volumes and diffusing capacity (DLCO). FeNO and CANO values were significantly increased in UC patients when compared with controls (p = 0.0008 and p < 0.0001, respectively) and were proportional to disease activity (FeNO class 3: 28.1 ppb vs. classes 1–2: 7.7 ppb; CANO values class 3: 8.6 ppb vs. classes 1–2: 2.7 ppb (p < 0.0001)). TLC and DLCO were significantly reduced in severe (Mayo 3) UC patients (p = 0.010 and p = 0.003, respectively). The results of this study show significant lung functional abnormalities in UC patients and suggest the presence of airway inflammation directly correlated with disease activity, suggesting the need for an integrated approach in routine assessment.
Relapses and Serious Infections in Patients with Neuromyelitis Optica Spectrum Disorder Treated with Rituximab: A Swedish Single-Center Study
Authors: Carlsson Olof , Jonsson Dagur Ingi , Brundin Lou , Iacobaeus Ellen
Published: January 2024

Neuromyelitis optica spectrum disorder (NMOSD) is a rare immune-mediated relapsing-remitting disease of the central nervous system. The usage of rituximab, as relapse-preventive therapy, in NMOSD is common. We performed a single-center retrospective cohort study to assess the risk of relapses and severe infectious events (SIEs) in rituximab-treated NMOSD patients. This study included 24 aquaporin-4 IgG+ (AQP4+), 8 myelin-oligodendrocyte-protein IgG+ (MOG+), and 10 double-seronegative NMOSD patients. Relapses were observed in 50% of all patients during a mean treatment time of 4.0 (range: 0.5–8.25) years. The incidence risk ratio (IRR) of relapse was three times higher in MOG+ compared to AQP4+ patients (IRR: 3.0, 95% confidence interval (CI); 1.2–7.7). SIEs occurred in 40% of all patients during follow-up. AQP4+ patients conferred an increased risk of SIEs compared to MOG+ patients (IRR; 5.3, 95% CI; 1.2–24.3). Incomplete CD19+ B-lymphocyte suppression was not correlated with relapse risk (hazard ratio; 1.9, 95% CI; 0.7–5.2), and there was no correlation between IgG-levels and SIE risk (odds ratio; 2.0, 95% CI; 0.8–4.8). In conclusion, considerable risks of both relapses and SIEs were observed in NMOSD patients exposed to rituximab, which underlines the need for close clinical vigilance of disease activity and infections during treatment.
New 3D Printed Scaffolds Based on Walstromite Synthesized by Sol–Gel Method
Authors: Chiriac Ştefania , Popescu Roxana-Cristina , Pele Mihnea-Mihăiță , Ghiţulică Cristina-Daniela , Cucuruz Andreia , Geanaliu-Nicolae Ruxandra-Elena , Stancu Izabela-Cristina , Voicu Georgeta , Ciocan Lucian-Toma
Published: January 2024

This study explores the potential utilization of walstromite (BaCa2Si3O9) as a foundational material for creating new bioceramics in the form of scaffolds through 3D printing technology. To achieve this objective, this study investigates the chemical–mineralogical, morphological, and structural characteristics, as well as the biological properties, of walstromite-based bioceramics. The precursor mixture for walstromite synthesis is prepared through the sol–gel method, utilizing pure reagents. The resulting dried gelatinous precipitate is analyzed through complex thermal analysis, leading to the determination of the optimal calcination temperature. Subsequently, the calcined powder is characterized via X-ray diffraction and scanning electron microscopy, indicating the presence of calcium and barium silicates, as well as monocalcium silicate. This powder is then employed in additive 3D printing, resulting in ceramic scaffolds. The specific ceramic properties of the scaffold, such as apparent density, absorption, open porosity, and compressive strength, are assessed and fall within practical use limits. X-ray diffraction analysis confirms the formation of walstromite as a single phase in the ceramic scaffold. In vitro studies involving immersion in simulated body fluid (SBF) for 7 and 14 days, as well as contact with osteoblast-like cells, reveal the scaffold’s ability to form a phosphate layer on its surface and its biocompatibility. This study concludes that the walstromite-based ceramic scaffold exhibits promising characteristics for potential applications in bone regeneration and tissue engineering.
Combining Synthetic Images and Deep Active Learning: Data-Efficient Training of an Industrial Object Detection Model
Authors: Eversberg Leon , Lambrecht Jens
Published: January 2024

Generating synthetic data is a promising solution to the challenge of limited training data for industrial deep learning applications. However, training on synthetic data and testing on real-world data creates a sim-to-real domain gap. Research has shown that the combination of synthetic and real images leads to better results than those that are generated using only one source of data. In this work, the generation of synthetic training images via physics-based rendering is combined with deep active learning for an industrial object detection task to iteratively improve model performance over time. Our experimental results show that synthetic images improve model performance, especially at the beginning of the model’s life cycle with limited training data. Furthermore, our implemented hybrid query strategy selects diverse and informative new training images in each active learning cycle, which outperforms random sampling. In conclusion, this work presents a workflow to train and iteratively improve object detection models with a small number of real-world images, leading to data-efficient and cost-effective computer vision models.
Classification of Cocoa Beans by Analyzing Spectral Measurements Using Machine Learning and Genetic Algorithm
Authors: Ayikpa Kacoutchy Jean , Gouton Pierre , Mamadou Diarra , Ballo Abou Bakary
Published: January 2024

The quality of cocoa beans is crucial in influencing the taste, aroma, and texture of chocolate and consumer satisfaction. High-quality cocoa beans are valued on the international market, benefiting Ivorian producers. Our study uses advanced techniques to evaluate and classify cocoa beans by analyzing spectral measurements, integrating machine learning algorithms, and optimizing parameters through genetic algorithms. The results highlight the critical importance of parameter optimization for optimal performance. Logistic regression, support vector machines (SVM), and random forest algorithms demonstrate a consistent performance. XGBoost shows improvements in the second generation, followed by a slight decrease in the fifth. On the other hand, the performance of AdaBoost is not satisfactory in generations two and five. The results are presented on three levels: first, using all parameters reveals that logistic regression obtains the best performance with a precision of 83.78%. Then, the results of the parameters selected in the second generation still show the logistic regression with the best precision of 84.71%. Finally, the results of the parameters chosen in the second generation place random forest in the lead with a score of 74.12%.
Exploring Microvariation in Verb-Movement Parameters within Daco-Romanian and across Daco-Romance
Authors: Costea Ștefania , Ledgeway Adam
Published: January 2024

This article reviews some of the principal patterns of morphosyntactic variation within Daco-Romanian and across Daco-Romance in support of a distinction between low vs high V-movement grammars variously distributed in accordance with diatopic variation (Daco-Romance: west vs east, Aromanian: north vs south), diachronic and diagenerational variation (Megleno-Romanian) and endogenous vs exogenous factors (Istro-Romanian). This approach, which builds on the insights of the Borer–Chomsky conjecture, assumes that the locus of parametric variation lies in the lexicon and the (PF-)lexicalization of specific formal feature values of individual functional projections, in our case the clausal heads T and v and the broad cartographic areas that they can be taken to represent. In this way, our analysis locates the relevant dimensions of (micro)variation among different Daco-Romance varieties in properties of T and v. In particular, we show that the feature values of these two heads are not set in isolation, inasmuch as parameters form an interrelated network of implicational relationships: the given value of a particular parameter entails the concomitant activation of associated lower-order parametric choices, whose potential surface effects may consequently become entirely predictable, or indeed render other parameters entirely irrelevant. In this way we can derive properties such as verb–adverb order, auxiliary selection, retention vs loss of the preterite, the availability of a dedicated preverbal subject position, the distribution of DOM, and the different stages of Jespersen’s Cycle across Daco-Romance quite transparently, based on the relevant strength of T and v in individual sub-branches and sub-dialects.
Impact of Aortic Root Abscess on Surgical Outcomes of Infective Endocarditis
Authors: Elderia Ahmed , Wallau Anna-Maria , Bennour Walid , Gerfer Stephen , Gaisendrees Christopher , Krasivskyi Ihor , Djordjevic Ilija , Wahlers Thorsten , Weber Carolyn
Published: January 2024

Locally destructive infective endocarditis (IE) of the aortic valve complicated by abscess formation in the aortic root may seriously affect patients’ outcomes. Surgical repair of such conditions is often challenging. This is a single-center observational analysis of consecutive patients treated surgically for IE between 2009 and 2019. We divided the cohort into two groups considering the presence of an aortic root abscess and compared the characteristics and postoperative outcomes of patients accordingly. Moreover, we examined three different procedures performed in abscess patients regarding operative data and postoperative results: an isolated surgical aortic valve replacement (AVR), AVR with patch reconstruction of the aortic root (AVR + RR) or the Bentall procedure. The whole cohort comprised 665 patients, including 140 (21.0%) patients with an aortic root abscess and 525 (78.9%) as the control group. The abscess group of patients received either AVR (66.4%), AVR + RR (17.8%), or the Bentall procedure (15.7%). The mean age in the whole cohort was 62.1 ± 14.8. The mean EuroSCORE II was 8.0 ± 3.5 in the abscess group and 8.4 ± 3.7 in the control group (p = 0.259). The 30-day and 1-year mortality rates were 19.6% vs. 11.3% (p = 0.009) and 40.1% vs. 29.6% (p = 0.016) in the abscess compared to the control group. The multivariable regression analysis did not reveal aortic root abscess as an independent predictor of mortality. Rather, age > 60 correlated with 30-day mortality and infection with Streptococcus spp. correlated with 1-year mortality. In the analysis according to the performed procedures, KM estimates exhibited comparable long-term survival (log-rank p = 0.325). IE recurrence was noticed in 12.3% of patients after AVR, 26.7% after AVR + RR and none after Bentall (p = 0.069). We concluded that patients with an aortic root abscess suffer worse short and long-term outcomes compared to other IE patients. The post-procedural survival among ARA patients did not significantly vary based on the procedures performed.
Role of Perturbated Hemostasis in MASLD and Its Correlation with Adipokines
Authors: Pezzino Salvatore , Luca Tonia , Castorina Mariacarla , Puleo Stefano , Latteri Saverio , Castorina Sergio
Published: January 2024

The prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) continues to rise, making it one of the most prevalent chronic liver disorders. MASLD encompasses a range of liver pathologies, from simple steatosis to metabolic dysfunction-associated steatohepatitis (MASH) with inflammation, hepatocyte damage, and fibrosis. Interestingly, the liver exhibits close intercommunication with fatty tissue. In fact, adipose tissue could contribute to the etiology and advancement of MASLD, acting as an endocrine organ that releases several hormones and cytokines, with the adipokines assuming a pivotal role. The levels of adipokines in the blood are altered in people with MASLD, and recent research has shed light on the crucial role played by adipokines in regulating energy expenditure, inflammation, and fibrosis in MASLD. However, MASLD disease is a multifaceted condition that affects various aspects of health beyond liver function, including its impact on hemostasis. The alterations in coagulation mechanisms and endothelial and platelet functions may play a role in the increased vulnerability and severity of MASLD. Therefore, more attention is being given to imbalanced adipokines as causative agents in causing disturbances in hemostasis in MASLD. Metabolic inflammation and hepatic injury are fundamental components of MASLD, and the interrelation between these biological components and the hemostasis pathway is delineated by reciprocal influences, as well as the induction of alterations. Adipokines have the potential to serve as the shared elements within this complex interrelationship. The objective of this review is to thoroughly examine the existing scientific knowledge on the impairment of hemostasis in MASLD and its connection with adipokines, with the aim of enhancing our comprehension of the disease.
A Transparent Hydrogel-Ionic Conductor with High Water Retention and Self-Healing Ability
Authors: Lee Yangwoo , So Ju-Hee , Koo Hyung-Jun
Published: January 2024

This study presents a transparent and ion-conductive hydrogel with suppressed water loss. The hydrogel comprises agarose polymer doped with sucrose and sodium chloride salt (NaCl–Suc/A hydrogel). Sucrose increases the water retention of the agarose gel, and the Na and Cl ions dissolved in the gel provide ionic conductivity. The NaCl–Suc/A gel shows high retention capability and maintains a 45% water uptake after 4 h of drying at 60 °C without encapsulation at the optimum gel composition. The doped NaCl–Suc/A hydrogel demonstrates improved mechanical properties and ionic conductivity of 1.6 × 10−2 (S/cm) compared to the pristine agarose hydrogel. The self-healing property of the gel restores the electrical continuity when reassembled after cutting. Finally, to demonstrate a potential application of the ion-conductive hydrogel, a transparent and flexible pressure sensor is fabricated using the NaCl–Suc/A hydrogel, and its performance is demonstrated. The results of this study could contribute to solving problems with hydrogel-based devices such as rapid dehydration and poor mechanical properties.
Comparative Fatigue Performance of Decarburized Surfaces in Railway Rails
Authors: Muttamara Apiwat , Sommanat Jinnaphat , Kanchanomai Chaosuan , Viyanit Ekkarut
Published: January 2024

This study explores the comparative fatigue performance of decarburized surfaces in railway components, emphasizing rolling contact fatigue, crack propagation, and acoustic emission. The investigation entails the examination of two grades of railway steels, namely R260 and U71Mn, to analyze crack and surface characteristics subsequent to fatigue testing employing a Twin Roller Machine. The purpose is to discern the impact of decarburization on the fatigue life of these materials. The results reveal distinct patterns in crack propagation and acoustic emission between decarburized and non-decarburized surfaces, providing valuable insights into the fatigue behavior of railway components. This comparative analysis contributes to a nuanced understanding of the material’s response to cyclic loading.
Using Recycled Tetrapak and Doped Titanyl/Vanadyl Phthalocyanine to Make Solid-State Devices
Authors: Sánchez Vergara María Elena , Toledo Dircio Emiliano , Cantera Cantera Luis Alberto , Bazán-Diaz Lourdes , Salcedo Roberto
Published: January 2024

In this work we studied the semiconductor behavior of titanyl phthalocyanine (TiOPc) and vanadyl phthalocyanine (VOPc), doped with anthraflavic acid and deposited on Tetrapak/graphite as flexible electrodes. The molecular structure was approached using the density functional theory and astonishingly, it was found that the structure and electronic behavior can change depending on the metal in the phthalocyanine. Experimentally, the Root Mean Square was found to be 124 and 151 nm for the VOPc-Anthraflavine and TiOPc-Anthraflavine films, respectively, and the maximum stress was 8.58 MPa for the film with VOPc. The TiOPc-Anthraflavine film presents the smallest fundamental gap of 1.81 eV and 1.98 eV for indirect and direct transitions, respectively. Finally, the solid-state devices were fabricated, and the electrical properties were examined. The tests showed that the current–voltage curves of the devices on Tetrapak and VOPc-Anthraflavine on a rigid substrate exhibit the same current saturation behavior at 10 mA, which is achieved for different voltage values. Since the current–voltage curves of the TiOPc-Anthraflavine on a rigid substrate presents a defined diode model behavior, it was approximated by nonlinear least squares, and it has been determined that the threshold voltage of the sample for the different lighting conditions is between 0.6 and 0.8 volts.
Clinical and Radiologic Analysis of Minimally Invasive Anterior–Posterior Combined Surgery for Adult Spinal Deformity: Comparison of Oblique Lateral Interbody Fusion at L5/S1 (OLIF51) versus Transforaminal Interbody Fusion
Authors: Kotani Yoshihisa , Ikeura Atsushi , Tanaka Takahiro , Saito Takanori
Published: January 2024

Background and Objectives: Although adult spinal deformity (ASD) surgery brought about improvement in the quality of life of patients, it is accompanied by high invasiveness and several complications. Specifically, mechanical complications of rod fracture, instrumentation failures, and pseudarthrosis are still unsolved issues. To better improve these problems, oblique lateral interbody fusion at L5/S1 (OLIF51) was introduced in 2015 at my institution. The objective of this study was to compare the clinical and radiologic outcomes of anterior–posterior combined surgery for ASD between the use of OLIF51 and transforaminal interbody fusion (TLIF) at L5/S1. Materials and Methods: A total of 117 ASD patients received anterior–posterior correction surgeries either with the use of OLIF51 (35 patients) or L5/S1 TLIF (82 patients). In both groups, L1–5 OLIF and minimally invasive posterior procedures of hybrid or circumferential MIS were employed. The sagittal and coronal spinal alignment and spino-pelvic parameters were recorded preoperatively and at follow-up. The quality-of-life parameters and visual analogue scale were evaluated, as well as surgical complications at follow-up. Results: The average follow-up period was thirty months (13–84). The number of average fused segments was eight (4–12). The operation time and estimated blood loss were significantly lower in OLIF51 than in TLIF. The PI-LL mismatch, LLL, L5/S1 segmental lordosis, and L5 coronal tilt were significantly better in OLIF51 than TLIF. The complication rate was statistically equivalent between the two groups. Conclusions: The introduction of OLIF51 for adult spine deformity surgery led to a decrease in operation time and estimated blood loss, as well as improvement in sagittal and coronal correction compared to TLIF. The circumferential MIS correction and fusion with OLIF51 serve as an effective surgical modality which can be applied to many cases of adult spinal deformity.