bluuebunny/crossref_metadata_2025 huggingface dataset:
Values Based Superior Students’ Learning Behaviour
Authors: Nadhirin N
Published: April 2019

The purpose of this research is to find (1) organizational behavior in superior school students learn (2) the source of values that underlies the attitude and behavior of superior student learning (3) superior student learning behavior in school and (4) learning interaction between teacher and student excel at school. This research uses qualitative approach and pospositivistic paradigm. The research data was collected by interview, observation and documentation. Technique of validity test data use triangulation, cover angulasi technique, source and time. Data were analyzed by Miles Hubermans interactive cycling technique, with cycle collecting, reducting, displaying and verifying. The subjects of this research are the leaders of madrasah, faculty, students and stakelholders of madrasah. Research location at MA. NU Banat, Kudus, Central Java, Indonesia. The results of this study are (1) Students who have good pretation in the field of academic and non academic are students who study in school organization unit that has commitment and spirit to go forward. A good and conducive organizational culture that is maintained by all members of the organization is very supportive to the achievement of superior and competitive student achievement (2) The source of values or outlooks that make the students become outstanding achievers is the accumulation of values formed from the religious family environment and dicipline, school environment consistent with the practice of religion in the school environment that inculcates values of virtue, dicipline in learning, honest, competitive and heed the norms prevailing in society. (3) behavioral typology and high school student learning attitudes are responsive stimuli. The more rules and structured tasks created by the school and the subject teachers, the students' attitudes and motivation will be more intense and vice versa (4) outstanding achievement students have a close relationship with the teacher. Teachers for students who excel are teachers who are not only as parents, as mentors, as well as teachers who can put themselves as friends of students, who can be invited to communicate closely and there is openness in various problems and teachers help students to solve problems encountered so that good achievement is greatly assisted by his teachers who are concerned primarily on non-academic issues.
TEACHING SUPERVISION OF MADRASAH HEADMASTER BASED ON PESANTREN CULTURE
Authors: Nadhirin Nadhirin
Published: April 2019

To realize the learning, it takes teaching supervision activities. The target of supervision is the teaching staff. The  purpose  of  this  paper  is  to  find  out  (1)  how  the teaching  supervision  activities  in  madrasah  is  (2)  how the techniques and approaches of supervision is (3) how the supervision of teaching in the madrasah is based on pesantren culture. The research method is library research with the technique of collecting the source of supervision theory of teaching through literature study and analysis technique   with   deductive-inductive    thinking   pattern. The results showed that (1) supervision of teaching in madarash is a function of leadership communication with pesantren  culture  so  the  relationship  between  teachers with the headmaster  or between  teachers  and students is to follow the pattern of relationship between kyai and santri (2) supervision approaches with a limited personal relationship approach and in an informal setting are much more effective because supervisory activities between teacher and headmaster are not open (3) teaching supervision  uses cultural  organization  group of religion technique (4) teaching supervision uses situational integrated approach.
Optimization of Vaccine Virus Accumulation in the Development of Smallpox Drugs Based on Cell Cultures
Authors: Ovchinnikov A. V. , Borisevich G. V. , Terent’ev A. I. , Pashchenko Yu. I. , Krotkov V. T. , Marchenko V. N. , Borisevich S. V. , Kuznetsov S. L.
Published: April 2019

Objective. Optimization of vaccine virus cultivation in the suspended cell culture BHK-21 for infectious activity increment of virus-containing suspension as the base material for smallpox vaccine preparations. Materials and methods. We used suspended culture line of the cells BHK-21 of 72-hour age and nutrient medium of the MEM type in accordance with the guidelines on preparation in our studies. For challenging of the cells, vaccine virus (strain B-51) was used. The virus was adapted through three consequent passages on horion-allantois shell of developing chicken embryos of commercial dermovaccine series 449а at the premises of the Federal State Budgetary Institution “the 48th Central Research Institute” of the Ministry of Defense of the Russian Federation. Information on its genetic features is absent. Cultivation and precipitation of infected cells BHK-21 was carried out in bioreactor with priming volume of 1 liter at (36.5±0.5) °C and aeration with air mixture with varying content of CO2. Results and conclusions. Gas  massexchange intensity was enhanced alongside simultaneous maintaining of sparing hydrodynamic conditions for mixing suspended cell cultures in bioreactor. Two-fold increase (up to (4.48±0.63)·109 cell/l) in suspended BHK-21 cell culture concentration at the end of reproduction cycle was achieved. Concentration of the vaccine virus was 3–5 times raised, from (8.1±0.3) lg PFU (plaque forming unit)/ml up to the level of infectious activity – (8.8±0.3) lg PFU/ml. Specific multiplicity of cell infection in recalculation per a cell was 1–5 PFU/cell and by virus yield – 20–100 PFU/cell. Enhanced infectious activity of the virus in concentrated suspension of infected BHK-21 cells substantiates the perspectives of the proposed method for improvement of vaccine virus accumulation phase in the development of anti-smallpox preparations based on cell cultures.
Psychometric Properties of Patient-Reported Outcome Measures for Periacetabular Osteotomy
Authors: Wasko Marcin K. , Yanik Elizabeth L. , Pascual-Garrido Cecilia , Clohisy John C.
Published: April 2019

Background:

Appropriate patient-reported outcome measures are paramount to determine the clinical relevance of change experienced by patients after a surgical procedure. The purpose of this study was to evaluate the psychometric properties of 3 patient-reported outcome measures (Hip disability and Osteoarthritis Outcome Score [HOOS], modified Harris hip score, and Western Ontario and McMaster Universities Osteoarthritis Index [WOMAC]) in a large population of patients treated with periacetabular osteotomy for symptomatic developmental dysplasia of the hip.

Methods:

Patients who underwent a periacetabular osteotomy for acetabular dysplasia between October 2011 and October 2016 completed multiple questionnaires preoperatively and at the 1-year follow-up. Internal consistency for subscores was evaluated with the Cronbach alpha. Validity was assessed against the Short Form-12. Interpretability included the calculation of the distribution of scores, floor and ceiling effects, and the minimal clinically important difference. Responsiveness was assessed by correlating the score changes with the Global Perceived Effect score.

Results:

Of 294 patients, 246 (84%) were female. The median age was 21 years (interquartile range, 17 to 29 years). All WOMAC and HOOS subscores demonstrated adequate internal consistency, and none of the modified Harris hip score components did. All scores except the WOMAC stiffness score exhibited adequate validity and interpretability, with no floor and ceiling effects over 15%. For the HOOS subscores, the minimal clinically important difference was 10.3 for pain, 10.2 for symptoms, 12.6 for sports and recreation, 11.2 for quality of life, and 10.8 for activities of daily living. The minimal clinically important difference for the modified Harris hip score was 7.4. For the WOMAC subscores, the minimal clinically important difference was 10.8 for pain, 12.9 for stiffness, 10.8 for physical, and 10.4 for total. All scores demonstrated adequate responsiveness.

Conclusions:

The HOOS, WOMAC, and modified Harris hip score have adequate psychometric properties for use in patients undergoing periacetabular osteotomy, with minor shortcomings. Among the scores analyzed, the HOOS appears to be the most appropriate measure of patient-reported outcome in patients undergoing periacetabular osteotomy.

Clinical Relevance:

By establishing the psychometric properties of patient-reported outcome measures for periacetabular osteotomy, this study enables a more informed choice of measures for clinical practice and research. The estimated minimal clinically important difference values will facilitate understanding the importance of change in patient-reported outcomes after a surgical procedure in a clinical setting and sample size calculation for further studies.
Pengaruh Jarak Tanam Terhadap Pertumbuhan dan Hasil Jagung (Zea mayz.L) Pada Tingkat Umur Kelapa Sawit (Elaeis guineensis Jacq) [The Effect Spacing of Growth and Yield Corn (Zea mayz.L) of The Palm Oil (Elaeis guineensis Jacq) Grade Aged]
Authors: Nur M , Nln Asrul , Nln Raffiudin
Published: April 2019

The research spacing of corn growth and yield of the palm oil various aged is to know the effect of the spacing, palm oil grade aged, and interaction. The research was conducted in  Central Mamuju regency.  West Sulawesi from July to October, 2016. Experiments in the form of  RAK 1 factor , the treatment is spacing of  50 cm x 25 cm, 60 cm x 25 cm and 70 cm x 25 cm,  performed on palm oil aged 1.5 years, 2.5 years, 3.5 years and without palm oil, and repeated 3. The result showed for 70 cm x 25 cm is the best for all grade aged. The best especially in general for, relative growth rate ( 9.93 g. plant-2.week- 1 ), grain yield (5.58ton ha-1)  of corm  of aged 2.5 yr palm oil  and there is interaction

 

ABSTRAK

Penelitian pengaruh jarak tanam terhadap pertumbuhan dan hasil jagung pada tingkat umur kelapa sawit dilakukan untuk mengetahui pengaruh jarak tanam dan tingkat umur kelapa sawit serta interaksi antara jarak tanam dan tingkat umur kelapa sawit terhadap pertumbuhan dan hasil jagung. Penelitian dilaksanakan di Kabupaten Mamuju Tengah Propinsi Sulawesi Barat, dari bulan Juli sampai Oktober tahun 2016. Percobaan dalam bentuk Rancangan Acak Kelompok 1 faktor, perlakuannya adalah jarak tanam  50 cm x 25 cm,  60 cm x 25 cm dan 70 cm x 25 cm. Perlakuan dilakukan pada kelapa sawit umur 1,5 tahun, 2,5 tahun dan 3,5 tahun dan tanpa kelapa sawit, dan 3 ulangan. Hasil penelitian menunjukkan bahwa Jarak tanam 70 cm x 25 cm terbaik  pada semua tingkat umur, dan jagung pada kelapa sawit umur 2,5 tahun  secara umum terbaik, terutama pada laju tumbuh relatif  (9,93 g tan2.minggu-1) , hasil biji pipilan (5,58 ton ha-1), dan ada interaksi.
PERTANGGUNGJAWABAN PIDANA PELAKU TINDAK PIDANA PERKOSAAN DITINJAU DARI PERSPEKTIF MORALITAS
Authors: Agustanti Rosalia Dika
Published: April 2019

Darurat tindak pidana perkosaan menjadi perhatian bahwa harus dicari penyebab seseorang melakukan tindak pidana perkosaan. Terjadinya tindak pidana perkosaan di tengah masyarakat mengidentifikasikan, bahwa korban demi korban terus berjatuhan dengan kerugian dan penderitaan yang sangat besar, maka bagaimana bentuk pertanggungjawaban  pidana pelaku tindak pidana perkosaan. Penelitian ini merupakan penelitian yuridis normatif, yaitu penelitian yang difokuskan untuk menguji penerapan kaidah atau norma-norma dalam hukum positif yang berlaku. Pendekatan yang digunakan yaitu pendekatan undang-undang (statute approach), pendekatan ini dilakukan dengan menelaah semua undang-undang dan regulasi yang bersangkut paut dengan isu hukum yang sedang ditangani dan pendekatan konseptual (conseptual approach), pendekatan ini beranjak dari pandangan-pandangan dan doktrin-doktrin yang berkembang di dalam ilmu hukum. Supaya orang bermoral baik, suatu perbuatan manusia harus sesuai dengan norma moralitas dalam tiga hal yaitu menurut hakikatnya, motifnya dan keadaannya. Ketidaksesuaian terhadap salah satu dari ketiganya menyebabkan perbuatan moral salah. Hal ini menjadi penyebab tindak pidana perkosaan di masyarakat semakin sering tejadi. Mengenai pertanggungjawaban pelaku tindak pidana perkosaan, supaya dapat dipidana, maka pelakunya haruslah memenuhi unsur-unsur sebagaimana dalam Pasal 285 KUHP. Jika salah satu dari kehendak atau maksud dan pengetahuan terdakwa tidak dapat dibuktikan, maka tidak ada alasan bagi penuntut umum untuk menyatakan terdakwa terbukti mempunyai kesengajaan dalam melakukan tindak pidana perkosaan, dan Hakim akan memberi putusan bebas dari tuntutan hukum bagi terdakwa. Dari sekian banyak penyebab terjadinya tindak pidana perkosaan, kesemuanya terjadi karena lingkungan seseorang tinggal, beradaptasi bahkan berkembang. Perkembangan seseorang menunjukkan kualitas atas dirinya, hal yang sangat mempengaruhi ialah moralitas seseorang.
Integrating Model Uncertainty in Probabilistic Decline-Curve Analysis for Unconventional-Oil-Production Forecasting
Authors: Hong Aojie , Bratvold Reidar B. , Lake Larry W. , Ruiz Maraggi Leopoldo M.
Published: April 2019

Decline-curve analysis (DCA) for unconventional plays requires a model that can capture the characteristics of different flow regimes. Thus, various models have been proposed. Traditionally, in probabilistic DCA, an analyst chooses a single model that is believed to best fit the data. However, several models might fit the data almost equally well, and the one that best fits the data might not best represent the flow characteristics. Therefore, uncertainty remains regarding which is the “best” model. This work aims to integrate model uncertainty in probabilistic DCA for unconventional plays.

Instead of identifying a single “best” model, we propose to regard any model as potentially good, with goodness characterized by a probability. The probability of a model being good is interpreted as a measure of the relative truthfulness of this model compared with the other models. This probability is subsequently used to weight the model forecast. Bayes' law is used to assess the model probabilities for given data. Multiple samples of the model-parameter values are obtained using maximum likelihood estimation (MLE) with Monte Carlo simulation. Thus, the unique probabilistic forecasts of each individual model are aggregated into a single probabilistic forecast, which incorporates model uncertainty along with the intrinsic uncertainty (i.e., the measurement errors) in the given data.

We demonstrate and conclude that using the proposed approach can mitigate over/underestimates resulting from using a single decline-curve model for forecasting. The proposed approach performs well in propagating model uncertainty to uncertainty in production forecasting; that is, we determine a forecast that represents uncertainty given multiple possible models conditioned to the data. The field data show that no one model is the most probable to be good for all wells.

The novelties of this work are that probability is used to describe the goodness of a model; a Bayesian approach is used to integrate the model uncertainty in probabilistic DCA; the approach is applied to actual field data to identify the most-probable model given the data; and we demonstrate the value of using this approach to consider multiple models in probabilistic DCA for unconventional plays.
Revascularization of Acute Stent Thrombosis after Carotid Artery Stenting in Clopidogrel Resistance Patient
Authors: Wang Pian , Wei Wei , Wang Yan , Li Zheng , Zhang Qingbin
Published: April 2019

Carotid Artery Stenting (CAS) is an alternative strategy to prevent ischemic stroke in patients who are at high-risk of surgery compared with carotid endarterectomy (CEA) .Acute carotid stent thrombosis (ACST) was extremely rare, but devastating complication after CAS. Academically, it occurred within 30 days after CAS. There are several reasons causing ACST, such as inadequate antiplatelet therapy, early discontinuation of antiplatelet therapy, clopidogrel resistance, hypercoagulable state, local vessel dissection, vasospasm, intimal injury, and so on. Although successful recanalization cases were reported, however, there is still a lack of experience in the choice of treatment methods and the timing of ACST treatment, especially when the patient has clopidogrel resistance. We are here to provide a case that successfully revascularization after ACST in patient with evidenced clopidogrel resistance, which was further confirmed by genetic testing. In our case, both thrombus aspiration and platelet glycoprotein IIb/IIIa antagonist (GPIs) were used for recanalization. Also, we review the literature and discuss appropriate treatment strategies for this deadly and rare event.
Paraspinal amyotrophy in DNM-2-related centronuclear myopathy
Authors: Kakiuchi Kensuke , Unoda Kiichi , Nakajima Hideto , Nishino Ichizo , Arawaka Shigeki
Published: April 2019

Background
Dynamin 2-related centronuclear myopathy (DNM2-CNM) is a rare congenital myopathy, and clinically, slowly progressive muscle weakness in the distal or proximal limbs, calf muscle atrophy, and pes cavus are features that are highly suggestive of DNM2-CNM. We experienced a case of DNM2-CNM who exhibited marked paraspinal amyotrophy on CT and showed a mutation in the GTPase effector domain (GED) of DNM2.
Case presentation
A 50-year-old man presented with a 5-year history of lumbar pain and slow progression of foot weakness. He showed bilateral pes cavus. Electromyography revealed a myopathic pattern, and nerve condition velocities and amplitudes were normal. Muscle CT showed marked fat replacement in the posterior compartment of the lower extremities, and also demonstrated severe involvement of the erector spinae muscles. Muscle biopsy from quadriceps femoris showed nuclear centralization in the majority of fibers. Sequence analysis of Dynamin 2 (DNM-2) demonstrated heterozygous c.1948G>A (p.E650 K) mutation compatible with the diagnosis of DNM2-CNM.
Conclusions
This case suggests that marked paraspinal amyotrophy may be a characteristic feature of DNM2-CNM. The selective involvement of the erector spinae muscles and posterior compartment of the lower extremities could offer a valuable feature for the diagnosis of DNM2-CNM.
Application of concomitant disease scoring in acute cerebral infarction
Authors: Zhao Xiao-Jing , Li Qun-Xi , Liu Ying , Chang Li-Sha , Chen Rui-Ying , Fan Hai-Yan , Zheng Fu-Xia
Published: April 2019

Background: This study aims to explore the predictive value of concomitant disease scoring for the prognosis of patients with acute cerebral infarction (ACI). Methods: A total of 399 patients with ACI, who met the inclusion criteria, were enrolled into the present study. The concomitant disease score was assessed within 24 hours after admission, and the risk degree of death was analyzed. Then, the goodness of fit test and validity analysis were carried out, the best survival/death cut-off value was determined, and its predictive value for the prognosis of ACI patients was assessed. Results: The area under the receiver operating characteristic (ROC) curve for the concomitant disease score was 0.700, the distinctiveness was relatively good, and the prediction cut-off value was 10 points. Furthermore, the mortality rate of patients with a higher score was significantly higher, when compared to patients with a lower score. Conclusion: This concomitant disease score has good predictive value for the prognosis of ACI patients, and is an ideal system for evaluating the condition of cerebral infarction. The survival/death cut-off value was 10 points.
Traffic Police Officers’ Experience of Post-crash Care to Road Traffic Injury Victims: A Qualitative Study in Dar es Salaam, Tanzania
Authors: Lukumay Gift G. , Mkoka Dickson A. , Outwater Anne H. , Ndile Menti L. , Saveman Britt-Inger
Published: April 2019

Background

Recently, road traffic injuries (RTIs) have become a major health problem affecting health systems in many low- and middle-income countries. Regardless of whether an ambulance is available for evacuation, police officers have been shown to arrive at the crash scene first, becoming, in effect, the first responders to RTI victims. The experiences of traffic police officers who have provided care to RTI victims in the prehospital environment was therefore the focus of the present study.

Method

The study used a qualitative approach in which data were obtained from 10 in-depth interviews and three focus group discussions. Data were collected in Dar es Salaam Region, Tanzania, in three phases from December 2017 to June 2018 by means of an interview guide designed by the researchers. Qualitative content analysis was used to analyse all the materials.

Results

Three themes emerged from the analysis. The theme “Maintain safety while saving injured victims’ lives and facilitating access to a health facility” was comprised of safety, sorting, initial help, and assisting access to hospital care. “Overwhelmed working with limited resources and support” included limited care and transport resources, police fatigue, and little or no support. “Improving supportive system and empowering frontline personnel” included the need for an emergency care system, availability of resources and an emergency medical support system, and training for police and drivers regarding victims’ first-aid care, and road safety.

Conclusion

The study findings characterize an environment in which the police first responders have no knowledge or skills and no equipment and supplies to provide care to RTI victims at the scene before rushing them to definitive care. The results suggest a favorable climate for training and equipping police officers so that they can deliver competent postcrash care at the scene while emergency medical services are yet to be established. However, more research will be needed to determine the efficacy of such training and its acceptability in the Tanzanian context.
HOSENG trial – Effect of the provision of oral self-testing for absent and refusing individuals during a door-to-door HIV testing campaign on testing coverage: protocol of a cluster randomized clinical trial in rural Lesotho
Authors: Amstutz Alain , Lejone Thabo Ishmael , Khesa Lefu , Muhairwe Josephine , Nsakala Bienvenu Lengo , Tlali Katleho , Bresser Moniek , Vanobberghen Fiona , Kopo Mathebe , Kao Mpho , Klimkait Thomas , Battegay Manuel , Labhardt Niklaus Daniel , Glass Tracy Renée
Published: April 2019

BACKGROUND
HIV testing coverage remains below the targeted 90% despite efforts and resources invested. Home-based HIV testing is a key approach endorsed by the World Health Organization (WHO), especially to reach individuals who might not seek testing otherwise. Although acceptance of test-ing during such campaigns is high, coverage remains low due to absent household members. This cluster-randomized trial aims to assess increase in testing coverage using oral HIV self-testing (HIVST) among individuals who are absent or decline testing during home-based HIV testing.

METHODS
The HOSENG (HOme-based SElf-testiNG) trial is a cluster-randomized, parallel group, superiority trial in two districts of Lesotho, Southern Africa. Clusters are stratified by district, village size, and village access to the nearest health facility. Cluster eligibility criteria include: village is in catchment area of one of the study facilities, village authority provides consent, and village has a registered, capable and consenting village health worker (VHW). In intervention clusters, HIV self-tests are provided for eligible household members who are absent or decline HIV testing in presence of the campaign team. In control clusters, standard of care for absent and refusing individuals applies, i.e. referral to health facility. The primary outcome is HIV testing coverage among individuals 12 years and older within 120 days after enrolment. Secondary objectives include HIV testing coverage among other age groups, and uptake of the different testing modalities. Statistical analyses will be conducted and reported in line with CONSORT guidelines. HOSENG trial is linked to VIBRA (Vil-lage-Based Refill of ART) trial. Together, they constitute the GET ON (GETting tOwards Ninety) research project.

DISCUSSION
The HOSENG trial tests if oral HIVST may be an add-on during door-to-door testing campaigns towards achieving optimal testing coverage. The provision of oral self-test kits, followed up by VHWs, requires little additional human resources, finances and logistics. If cost-effective, this approach will inform home-based HIV testing policies not only in Lesotho, but in similar high-prevalence settings.

TRIAL REGISTRATION
This trial has been registered at clinicaltrials.gov (NCT03598686) on July 25, 2018. More information under www.getonproject.wordpress.com.
Retinal Function determined by Flicker ERGs before and soon after Intravitreal Injection of Anti-VEGF Agents
Authors: Terauchi Gaku , Shinoda Kei , Sakai Hiroyuki , Kawashima Makoto , Matsumoto Soichi , Mizota Atsushi , Miyake Yozo
Published: April 2019

Background: To evaluate the retinal function before and soon after an intravitreal injection of an anti-vascular endothelial growth factor (anti-VEGF) agents.
Methods: Seventy-nine eyes of 79 patients that were treated by an intravitreal injection of an anti-VEGF agent for age-related macular degeneration (AMD), diabetic macular edema (DME), or retinal vein occlusion (RVO) with macular edema (ME) were studied. The RETeval® system was used to record 28 Hz flicker electroretinograms (ERGs) from the injected and non-injected eyes before (Phase 1, P1), within 2 hours after the injection (P2), and 2 to 24 hours after the injection (P3). Patients were grouped by disease or by the injected agent and compared. The significance of the changes in the implicit times and amplitudes was determined by t tests.
Results:
The amplitudes were not significantly different at the three phases. The implicit time of the injected eye was 31.2±3.2 msec at P1, and it was not significantly different at P2 (31.7±3.1 msec) but it was significantly longer at P3 (32.2±3.3 msec, P<0.01, ANOVA for both). The implicit time in the non-injected fellow eye was 30.5±3.3 msec at P1, and it was significantly longer at P2 (31.1±3.2 msec) and phase 3 (31.3±3.4 msec, P<0.01, ANOVA for both).
Conclusions: The results indicate that an intravitreal anti-VEGF injection will increase the implicit times not only in the injected eye but also in the non-injected eye soon after the intravitreal injection.
Desarrollo de estación de carga de vehículos eléctricos
Authors: Restrepo Laverde José Valentín Antonio , Tobón Ramírez Diego Alejandro
Published: April 2019

Se presenta el desarrollo de una estación de carga para vehículo eléctrico, comenzando por la búsqueda de similitudes en patentes de desarrollos afines. Se dan a conocer algunos conectores usados para cargar vehículos eléctricos con su respectiva distribución de pines, quién lo desarrolló, dónde se desarrolló y se mencionan algunos vehículos que incorporan tales conectores. El conector elegido para la estación de carga fue el estándar SAE J1772. El funcionamiento de la estación se da a partir de la integración de cinco módulos que se encargan de llevar a cabo el proceso de carga y la transmisión y recepción de información a través de diferentes protocolos de comunicación. Adicionalmente, se detalla el funcionamiento de la estación de carga y del hardware utilizado para la elaboración de esta.
Sistema Meteorológico con Comunicación Remota Usando Zigbee
Authors: Marín García Edward Jhohan , Torres Marín José Neftalí , Serna Ruiz Andrés Felipe
Published: April 2019

El presente artículo presenta la implementación de una estación meteorológica la cual permite observar en el lugar de medición y de forma remota, el cambio de las distintas variables climáticas como: la velocidad del viento, precipitación de lluvia, temperatura y humedad relativa del ambiente. Inicialmente se hace la respectiva caracterización de los sensores utilizados, para el caso, el anemómetro, pluviómetro y el termo higrómetro, por medio de un patrón y las especificaciones dadas por el fabricante. Estos datos son representados gráficamente generando la ecuación de tendencia, evaluada con su correlación correspondiente. Seguidamente del proceso de caracterización, por medio de la plataforma Arduino, se programa la lectura de los sensores e igualmente él envió inalámbrico de datos por medio de módulos Xbee, Zigbee. Como proceso final, los datos son visualizados en una pantalla de cristal líquido ubicada en la estación meteorológica y en el receptor por medio de un ordenador previamente configurado.
Impacto de los Proyectos Universitarios en la Planeación Local, El Hábitat Rural y el Desarrollo Agropecuario Local del Municipio Camajuaní, Cuba
Authors: Hernández Medina Carlos Alberto , Carrasco Fuentes Magdalys Alibet , Báez Hernández Alexander
Published: April 2019

Este trabajo explora cómo contribuyen los proyectos al fortalecimiento del Desarrollo Agropecuario Local de un municipio cubano. Se precisan los aportes de la gestión de proyectos al tejido productivo en las comunidades campesinas desde la investigación de profesores y estudiantes. Los proyectos juegan un papel importante en el fortalecimiento del tejido productivo en Camajuaní y contribuyen al Desarrollo Local en la generación de empleos, la incorporación de la mujer al trabajo agrícola, el incremento de la repoblación forestal, incorporación de nuevas variedades de bambú que pueden ser utilizadas en obras constructivas y fabricación de muebles y útiles del hogar, ampliación de infraestructuras y mejoría de las existentes, diversificación de la producción y producción de abonos naturales y materia orgánica para lograr mayor fertilidad del suelo y productos más saludables.
Violación de principios constitucionales y legales en el contrato No. 638 de 2013
Authors: Giraldo Quintero Valencia Rodrigo , Giraldo Valencia Elkin Octavio
Published: April 2019

El objetivo de la investigación, se enmarca en determinar los principios de contratación estatal violados en el contrato No. 638 de 2013. Por tanto, este estudio investigativo es de tipo cualitativo, con método hermenéutico y el enfoque empleado es descriptivo analítico. En consecuencia, se busca en la interpretación del contrato estatal de la máquina tapahuecos de Bogotá, permitir identificar y descomponer las partes o elementos del fenómeno y así observar sus causas, la naturaleza y los efectos. En la dinámica del diseño metodológico se realizó una triangulación teórica jurídica (constitucional, jurisprudencial y normativa), partiendo de fuentes bibliográficas y web gráficas de normas constitucionales, legales, reglamentarias, jurisprudencia de las Altas Cortes, doctrina especializada en contratación estatal e informes proferidos en la actuación administrativa por parte de los órganos de control fiscal. Se empleó la recolección de datos documentales, que proporcionaron diversas interpretaciones en los análisis de los principios violentados en la contratación estatal. La investigación, se concluye determinando que en el contrato No. 638 de 2013, fueron violados los principios de planeación, eficacia, eficiencia, economía, publicidad y los principios constitucionales y fundamentales de la prevalencia del interés general, los fines esenciales del Estado en conexidad con el derecho fundamental de igualdad.
Perfil psicológico y neuropsicológico de víctimas del conflicto armado en Colombia
Authors: Jaramillo Osorio Naila Camila , Villa Carmona Lina Maribel , Tobón Zapata Yuly Tatiana , Munera Peréz Leidy Johana , Ospina Villa Eduardo Andrés , Quintero López Catalina
Published: April 2019

El conflicto armado en Colombia es una problemática compleja con consecuencias devastadoras de carácter social, económico y cultural. La presente investigación formativa realizada bajo la modalidad de estudio de caso, pretendió establecer si existe una relación entre el perfil psicológico y neuropsicológico de diez (10) víctimas del conflicto armado, pertenecientes a la Asociación Caminos de Paz Madres de la Candelaria, con el conocimiento y la posición que asumen frente al posconflicto. Se les aplicó la prueba psicológica 16PF, cuatro subpruebas de la escala Wechsler para Adultos (WAIS-IV) y un cuestionario de conocimiento y posición sobre temas del posconflicto. Los resultados evidenciaron que existe relación entre los rasgos de su personalidad y sus habilidades cognitivas, con respecto a la posición y el conocimiento que tienen sobre el posconflicto, por lo tanto, se proponen investigaciones a mayor escala con el fin de obtener resultados más significativos que permitan crear estrategias orientadas hacia una cátedra para la paz, según las características de la población.
Preparation of the intestine for colonoscopy of women with reproductive system pathology
Authors: Stoletova T. A.
Published: April 2019

Aim: to evaluate the efficacy of Picoprep for colonoscopy preparation in women with pelvic pathology.

Patients and methods: during the period from January 2018 to December 2018 in the Federal State Budgetary Institution «National Medical Research Center of Obstetrics, Gynecology and Perinatology named after V.I.Kulakov’’ of the Ministry of Health of the Russian Federation, 873 diagnostic video-colonoscopies were performed on women of reproductive age (from 23 to 41 years of age) in the surgical department of the Department of Operational Gynecology and General Surgery. Macrogol and Picoprep were used in preparation for the study. 512 (58.7%) of the total number of performed colonoscopies were performed after colon preparation with Picoprep.

Results: quality of colon preparation with Picoprep: excellent – 168 (32.7%), good – 275 (53.7%), satisfactory – 66 (13%), unsatisfactory – 3 (0.6%).

Conclusion: The effectiveness of Picoprep does not differ from the quality of preparation with the use of alternative preparations of Macrogol, but significantly exceeds them in tolerability by patients.
Nonsteroidal anti-inflammatory drugs for management of pelvic pain in women
Authors: Kuznetsova I. V. , Evsyukova L. V.
Published: April 2019

Pelvic pain is one of the common causes for visiting a doctor, which can be the main symptom of gynecological diseases and an independent pathological condition. Acute pelvic pain is most often caused by an infection that affects the organs of a woman’s reproductive system. Non-infectious causes of pain are also associated with inflammation, and estrogens support pain and inflammation in women, which increases the risk of chronic pelvic pain (CPP). The urgency of the pelvic pain problem is considered not only in connection with an adequate diagnosis of its causes, but also from the perspective of managing the pain symptoms themselves. The anaesthesia strategy significantly improves the quality of life and prevents the development of chronic inflammatory diseases and CPP syndrome. Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used in pain therapy, and their effect consists in reducing the synthesis of prostaglandins and is pathogenetically substantiated both in the complex treatment of acute pelvic infections and in the treatment of idiopathic menstrual pain. The article presents clinical observations of the use of NSAIDs with the specified purpose.
Modern approaches to the treatment of postpartum purulent-septic diseases
Authors: Ivannikov N. Yu. , Mitichkin A. E. , Dimitrova V. I. , Slyusareva O. A. , Khlynova S. A. , Dobrokhotova Ju. E.
Published: April 2019

The cohort prospective comparative study showed improvement of the management of patients with various forms of purulentseptic diseases (PSD). The study included 276 women with PSD admitted to the gynecological hospital from January 1, 2014 to December 31, 2016. The patients were divided into two cohorts depending on the clinical course, management, and outcomes, which corresponded to the clinical forms of PSD: uncomplicated and complicated. The parameters that were evaluated in patients in both groups included complaints, pregnancy course and childbirth, duration of manifestations of the disease, the clinical picture, laboratory parameters. The study resulted in the development of an algorithm for management of patients with PSD including lavage of the site of infection, adequate antibiotic therapy depending on the type of pathogen, infusion and anticoagulant therapy, and treatment of vaginitis. The developed algorithm for management of patients with various forms of postpartum PSD allowed all 276 (100%) participants to preserve reproductive function and avoid early postoperative complications.
First stage of medical rehabilitation of patients after spontaneous miscarriage
Authors: Ozolinya L. A. , Ovsepyan N. R. , Savchenko T. N.
Published: April 2019

The article presents a discussion of the issue of management of patients after spontaneous abortion to prevent inflammatory complications. The condition of 165 patients distributed randomly in two groups is analyzed. Attention was paid to a full-fledged microbiological examination, including bacterioscopy and modern methods of PCR-diagnostics: «Inbioflor(4+MHC)» and «Femoflor-16». Patients of the first group (85 people) were prescribed antibacterial therapy (doxycycline, metronidazole, povidoniodine), as well as modern methods of physiotherapy: magnetoinfrared laser and ozone therapy. The second group (80 people) received similar antibacterial therapy, without physiotherapy. The study showed that the best effect can be achieved with complex therapy, including antibacterial drugs and modern methods of physiotherapy.
Decolorization effect and related mechanism of atmospheric pressure plasma jet on Eriochrome Black T
Authors: Li Xiaoyan , Liu Jinren , Wu Yueming , Gao Lingge , Ma Yan , Xu Guimin , Li Guoqiang , Zhang Longlong , Li Miao , You Li , Shi Xingmin , Yuan Wang
Published: April 2019

In this study, Eriochrome Black T (EBT) in water was decolorized by means of argon atmospheric pressure plasma jet (APPJ), which showed great decolorization performance. The results showed that the relatively high decolorization rate (approximately 80%) was obtained after plasma treatment for 6 min. Changes to some reactive oxygen and nitrogen species (RONS) in the liquid phase were detected. The contents of peroxide, HO·, O2−·, and NO· in the plasma-treated EBT solution were much less than those in the activated water. The roles of H2O2 and HO· in the decolorization of EBT solution were explored by evaluating the effects of their scavengers, and by exploring the direct effect of H2O2. The results indicated that reactive oxygen species (ROS), especially HO· and O2−·, played significant roles in the decolorization of the EBT solution. Analysis of degradation by-products indicated that plasma discharge could destroy the azo bond first and gradually break the aromatic rings of EBT molecules into small molecular compounds.
Temperature influence on homogeneous instabilities in stationary shear flow of nematic liquid crystal with weak surface anchoring
Authors: Nasibullayev I.Sh. , Urina O.V.
Published: April 2019

Plane stationary shear flow of the nematic liquid crystal with weak surface anchoring is investigated. The effect of temperature, external fields, and the nature of the surface coupling on the formation of orientation instabilities is investigated.
Stresses and deformations in the rod under the action on the end of the dynamic load
Authors: Yakupov R.G.
Published: April 2019

The stresses and deformations of a semi-infinite rod located in an elastic medium are considered when the dynamic load acts on the end face. Using the respect to time Laplace transform, a system of two differential equations of motion of the theory of Timoshenko beams has been solved. The integrals obtained are determined numerically. The graphs of the change in deflection and bending moment along the longitudinal coordinate are given.
Expression, Purification, and in vivo Evaluation of GFP-Fused M Cell Targeting Receptor Binding Domain of Protein FimH
Authors: Nguyen-Thi Thanh-Hoa , Huynh Kien-Quang , Dinh-Thi Phuong-Linh , Tran Linh-Thuoc , Jang Yong-Suk , Tran-Van Hieu
Published: April 2019

Background:

The number of oral vaccines is still limited due to many difficulties
suffered in the intestinal environment, such as mucosal clearance, vast area, harsh conditions,
deteriorative enzymes, impermeability, tolerance, etc. Numerous strategies have focused on
directing antigen to the receptors of M cells, which is the main gateway to acquire and initiate
specific responses to antigens in intestine. FimHrb is a receptor binding domain of type 1 of
fimbriae from E. coli and Salmonella that can bind to GP2 receptor expressed exclusively on M
cells.

Objective:

In this study, we evaluated the potential of FimHrb for oral vaccine development via its
ability to adhere M cells.

Methods:

The coding gene of FimHrb fused Green Fluorescent Protein (GFP) was cloned and
expressed intracellularly in E. coli host strain. The recombinant protein FimHrb-GFP was then
purified by IMAC method through 6x His tag designed downstream of GFP. Finally, the purified
protein was monitored its binding on murine M cells in Payer Patch region.

Results:

Following the methods mentioned above, the coding gene FimHrb-GFP was successfully
cloned into vector pET22b and intracellularly expressed in soluble form at low temperature
induction. The purity and the recovered yield of this protein were 90% and 20%, respectively. After
that, the adhesion of FimHrb-GFP was monitored in murine small intestine, which showed that the
protein bound to Peyer Patch region and did not restrict on M cells.

Conclusion:

With the present data, we revealed a candidate protein FimHrb targeted receptor on M
cells for oral vaccine development and other factors in E. coli would supplement FimH to provide
the specific invasion of these bacteria via M cells.
Beneficial Effects of the Angiotensin-Converting Enzyme 2 Activator Dize in Renovascular Hypertension
Authors: Kangussu Lucas Miranda , de Almeida Tatiane Cristine S. , Prestes Thiago Ruiz R. , de Andrade De Maria Marilda Luz , da Silva Filha Roberta , Vieira Maria Aparecida Ribeiro , Silva Ana Cristina Simões e , Ferreira Anderson José
Published: April 2019

Background:

Angiotensin Converting Enzyme (ACE) 2 is an important modulator of the Renin Angiotensin System (RAS) and the RAS plays a central role in renovascular hypertension. Very few studies investigated the role of components of the counterregulatory RAS axis (ACE2, Ang-(1-7) and Mas receptor) in renovascular hypertension and the results are controversial.

Objective:

The aim of this study was to investigate the effects of Diminazene Aceturate (DIZE) administration on renal function and renal inflammation parameters in 2K1C hypertensive rats.

Methods:

Male Wistar rats were divided into three experimental groups: sham-operated animals, 2K1C+saline and 2K1C+DIZE orally (1 mg/kg/day). At the end of the 30 days of treatment, renal function was analyzed and kidneys from all the groups were collected and processed separately for measurement of N-acetyl-beta-D-glucosaminidase (NAG) and Myeloperoxidase (MPO) activities, cytokines, chemokines and nitric oxide levels.

Results:

Oral DIZE administration for 4 weeks in hypertensive rats attenuated renal dysfunction and reduced the levels of MPO and NAG, cytokines and chemokines (IL1β, IL-6, TNF-α and MCP-1) and increased urinary nitrate/nitrite levels in 2K1C hypertensive rats.

Conclusion:

Our findings showed that ACE2 activation may effectively improve renal alterations and inflammation induced by renovascular hypertension.
FoxF1 is Required for Ciliogenesis and Distribution of Sonic Hedgehog Signaling Components in Cilium
Authors: Huang Lu , Tjakra Marco , Luo Desha , Wen Lin , Lei Daoxi , Wang Jinxuan , Yin Tieying , Zhang Xiaojuan , Huang Junli , Wang Yeqi , Wang Guixue
Published: April 2019

Background:

In vertebrates, cilium is crucial for Hedgehog signaling transduction. Forkhead box transcriptional factor FoxF1 is reported to be associated with Sonic Hedgehog (Shh) signaling in many cases. However, the role of FoxF1 in cilium remains unknown. Here, we showed an essential role of FoxF1 in the regulation of ciliogenesis and in the distribution of Shh signaling components in cilium.

Methods:

NIH/3T3 cells were serum starved for 24h to induce cilium. Meanwhile, shRNA was used to knockdown the FoxF1 expression in the cells and CRISPR/Cas9 was used to generate the FoxF1 zebrafish mutant. The mRNA and protein expression of indicated genes were detected by the qRT-PCR and western blot, respectively. Immunofluorescence staining was performed to detect the cilium and Shh components distribution.

Results:

FoxF1 knockdown decreased the cilium length in NIH/3T3 cells. Meanwhile, the disruption of FoxF1 function inhibited the expression of cilium-related genes and caused an abnormal distribution of Shh components in the cilium. Furthermore, homozygous FoxF1 mutants exhibited defective development of pronephric cilium in early zebrafish embryos.

Conclusion:

Together, our data illustrated that FoxF1 is required for ciliogenesis in vitro and in vivo and for the proper localization of Shh signaling components in cilium.
Inhibition of SOX15 Sensitizes Esophageal Squamous Carcinoma Cells to Paclitaxel
Authors: Zhang Ming , Wang Jianying , Gao Tianwei , Chen Xin , Xu Yan , Yu Xiaoting , Guo Xianyang , Zhuang Rong , Li Ziwei , Wu Hongjin , Yu Juehua
Published: April 2019

Background:

SOX15 is a crucial transcription factor involved in the regulation
of embryonic development and in the cell fate determination. It is also an important
mediator of tumorigenesis in cancer.

Methods:

Here, we sought to explore the expression patterns and biological functions of
SOX15 in esophageal squamous cell carcinomas (ESCC). SOX15 was found aberrantly
overexpressed in ESCC tumors.

Results:

Experimentally, inhibition of SOX15 through RNAi suppressed cell proliferation
in ESCC cells and sensitized cancer cells to paclitaxel, but not to Cisplatin. Moreover,
inhibition of SOX15 significantly repressed the expression of genes associated with
WNT and NOTCH signaling pathways, which may contribute to the increased sensitivity
to paclitaxel.

Conclusion:

In conclusion, the current study revealed that inhibition of SOX15 in ESCC
cells sensitizes the ESCC cells to paclitaxel, suggesting that the SOX15 expression level
may predict the therapeutic outcomes for paclitaxel treatment for ESCC.
Therapeutic Exploitation of Viral Interference
Authors: Kovesdi Imre , Bakacs Tibor
Published: April 2019

:

Viral interference, originally, referred to a state of temporary immunity, is a state whereby infection with a virus limits replication or production of a second infecting virus. However, replication of a second virus could also be dominant over the first virus. In fact, dominance can alternate between the two viruses. Expression of type I interferon genes is many times upregulated in infected epithelial cells. Since the interferon system can control most, if not all, virus infections in the absence of adaptive immunity, it was proposed that viral induction of a nonspecific localized temporary state of immunity may provide a strategy to control viral infections. Clinical observations also support such a theory, which gave credence to the development of superinfection therapy (SIT). SIT is an innovative therapeutic approach where a non-pathogenic virus is used to infect patients harboring a pathogenic virus.

:

For the functional cure of persistent viral infections and for the development of broad- spectrum antivirals against emerging viruses a paradigm shift was recently proposed. Instead of the virus, the therapy should be directed at the host. Such a host-directed-therapy (HDT) strategy could be the activation of endogenous innate immune response via toll-like receptors (TLRs). Superinfection therapy is such a host-directed-therapy, which has been validated in patients infected with two completely different viruses, the hepatitis B (DNA), and hepatitis C (RNA) viruses. SIT exerts post-infection interference via the constant presence of an attenuated non-pathogenic avian double- stranded (ds) RNA viral vector which boosts the endogenous innate (IFN) response. SIT could, therefore, be developed into a biological platform for a new “one drug, multiple bugs” broad-spectrum antiviral treatment approach.