bluuebunny/crossref_metadata_2025 huggingface dataset:
Importance of Integrating Traditional Physical Education into Physical Education Teaching Using Big Data
Authors: Qiang Guo , Ya-mei Liu , Li Guo
Published: August 2022

In order to advance the assessment capability of the significance of integrating old-fashioned physical education into school physical education, an evaluation model of the significance of integrating old-fashioned physical education into school physical education founded on big data analysis of influencing factors of physical education quality is put forward. The big data analysis model of the significance of integrating old-fashioned physical education into school physical education was established, and the constraint parameter model was adopted to evaluate the significance of integrating old-fashioned physical education into school physical education by the method of objective elements collection of physical education teaching effect. Combined with the quantitative statistical analysis method of structural parameters of physical education system, the important parameter analysis model of integrating classical physical education into institution physical education was realized, and the inversion feature quantity of the significance evaluation of integrating classical physical education into institution physical education was extracted. Combining the questionnaire analysis method of influencing factors of institution physical education teaching quality, this paper realizes the piecewise linear estimation of the significance of classical physical education in institution physical education teaching, adopts the joint feature analysis method of quantitative rules, combines the quantitative analysis of indicators and the confidence test results of the significance of classical physical education in institution physical education teaching, and therefore realizes the fuzzy assessment of the significance of classical physical education in institution physical education teaching by fuzzy decision method. We realize the comprehensive evaluation decision of the significance of integrating classical sports into institution physical education. According to the big data mining results of the significance evaluation of integrating classical sports into institution physical education, realize the decision evaluation of the significance of integrating classical sports into institution physical education. The test outcomes express that this approach has good adaptability in evaluating the significance of integrating old-fashioned physical education into school physical education, and the confidence level of the evaluation results is higher than the other approaches.
Implementation of Key Technologies for a Healthy Food Culture Recommendation System Using Internet of Things
Authors: Xie Weiguang , Lou Hongliang
Published: August 2022

With the development of catering culture, the types of diets are changing with each passing day. The types of food are becoming more and more abundant, and the concept of healthy eating has become more and more prominent in people’s thinking. The development of Internet of Things technology enables people to live a variety of information in the network, and the amount of information increases sharply. With the development of the Internet of Things, the number of online recipes has increased significantly, and a number of choices are now available to people to find suitable recipes. It is still troublesome for people to select the menu of three meals on daily basis. In recent years, many people have long-term unhealthy eating habits, which has greatly increased the incidence of some diseases. Therefore, a balanced diet is very important for good health. This paper builds a fusion of healthy eating culture with the help of Internet of Things, deep learning, and other related technologies. A more practical healthy diet recommendation system is built, which aims to help people find diet recipes that conform to their personal eating preferences and habits and their health status. Experimental results show that the healthy food culture recommendation system constructed in this paper can more accurately recommend suitable healthy food recipes for individuals and promote people’s health. And the launched recipes can ensure nutrition and meet individual taste preferences, which has great practical significance.
Use of Green Chemistry for Amputation of Chromium Ions from Wastewater by Alkali-Treated Composts of Fruit Peels in Economical Way
Authors: Latif Shoomaila , Rehman Rabia , Imran Muhammad , Hira Uzma , Iqbal Shahid , Akram Mehwish , Mitu Liviu , Alsantali Reem I , Al-thagafi Zahrah T.
Published: August 2022

In this work, removal of chromium (VI) using alkali-treated composted peels of lemon (Citrus limonum), mango (Mangifera indica), water melon (Citrullus lanatus), and melon (Cucumis melo) has been studied in batch mode. Physico-chemical characteristics of each sorbent material were determined together with their subsequent characterization by scanning electron microscopic, FTIR, and TGA. The selected sorbent materials were chemically modified using nitric acid and sodium hydroxide solutions. Adsorption efficacy of the selected sorbent materials for Cr (VI) was investigated by optimizing different parameters. The most favorable conditions were as follows: adsorbent dosage = 1.2 g/50mL, pH = 4.0, agitation speed = 170 rpm, 60 minutes = contact time, and temperature = 313°K. Base-treated adsorbents were found to be better adsorbents as compared to the acid treated form which in turn are better than raw adsorbents (adsorbents without chemical modification). Overall, the chosen sorbents removed Cr (VI) in the range of 53.62–96%, whereas the maximum sorption is with base-treated water melon peels (BWMP), that is, 95.98%. The kinetic studies discovered that the results fitted with pseudo-second-order model. Thermodynamic parameters also support that under optimal conditions, all the selected sorbents specifically base-treated sorbents are good enough for the elimination of Cr (VI) ions in an eco-friendly way.
Application of Blockchain Based on Deep Learning Algorithm in Enterprise Internet of Things System
Authors: Guo Liang
Published: August 2022

The purpose of an IoT enterprise business system is to form a global open network structure. The main task of this process is to build the Internet of Things system based on the internal enterprise, and link the upstream and downstream enterprises to interact with the Internet of Things system. However, existing blockchain systems often have limited performance and capacity, so they cannot be used in many scenarios, resulting in reduced scalability. The most common solution is to use the deep learning algorithm to find the optimal blockchain parameters. Based on deep learning and blockchain technology, this article proposes an enterprise Internet of Things system, which divides the whole Internet of Things into three layers—device layer, edge layer, and application layer, so as to build a reliable edge layer platform, so as to integrate the application network and blockchain network of the enterprise Internet of Things system and ensure the data security of the enterprise Internet of Things system. Finally, in order to verify the design proposed in this article, we build a distributed IoT business system, implement the deployment of experimental datasets on multiple hardware platforms, and design experiments to verify the security and effectiveness of the system designed in this work. By using blockchain technology based on the deep learning algorithm, the accuracy and time efficiency of the enterprise Internet of Things system are improved, and the burden of enterprise operators is greatly reduced. This article studies the deep learning algorithm and blockchain technology, and applies it to the design process of the enterprise Internet of Things system, thus promoting the development of the enterprise Internet of Things system.
Influence of Drying–Wetting Cycles on the Water Retention and Microstructure of Residual Soil
Authors: Xu Xu-tang , Liu Dao-qi , Xian Zhen-xing , Yang Feng , Jian Wen-bin , Xu Xiang , Huang Jian-bin
Published: August 2022

Due to frequent changes in the humid and hot environment, the residual soil with a particle-size distribution (PSD) from gravel to clay experiences multiple drying–wetting cycles. The pressure plate test and nuclear magnetic resonance (NMR) spectroscopy were used to investigate the influence of drying–wetting cycles on the soil–water characteristic curve (SWCC) and pore-size distribution (POSD) of undisturbed residual soil. The results showed that the water-holding capacity of the residual soil decreased as the number of drying–wetting cycles increased and gradually stablilized, and then the van Genuchten (VG) model was found to perform well on the SWCC during the drying–wetting processes. The NMR results indicated a double-pore structure, and the porosity of the residual soil as well as the internal water content increased smoothly with more drying–wetting cycles. The obtained POSD curve of soil implied that drying–wetting cycles had a more obvious effect on small pores and macro-pores than on micro-pores and meso-pores. Theoretical calculations evinced that the product of the matric suction and relaxation time should be constant at a constant temperature. However, the experimental results did not effectively reflect such a relation between the matric suction and relaxation time. A modified VG model based on the cumulative pore volume was utilized to describe the POSD under drying–wetting cycles. Subsequently, the proposed Rational2D surface equation was used to accurately reflect the internal relationship between the SWCC and POSD curve under different numbers of drying–wetting cycles. Moreover, the fractal model for the SWCC derived from the capillary theory confirmed that the matric suction had a strong linear relationship with the relative volumetric water content in the log-log scale. Also, the fractal dimension can be approximated as a constant, because its attenuation is small with more drying–wetting cycles.
Bioinformatically Expanded Next-Generation Sequencing Analysis Optimizes Identification of Therapeutically Relevant MET Copy Number Alterations in >50,000 Tumors
Authors: Solomon James P. , Yang Soo-Ryum , Choudhury Noura J. , Ptashkin Ryan N. , Eslamdoost Nasrin , Falcon Christina J. , Martin Axel , Plodkowski Andrew , Wilhelm Clare , Shen Ronglai , Ladanyi Marc , Berger Michael , Zhang Yanming , Drilon Alexander , Arcila Maria E.
Published: August 2022

Purpose:

Clinical relevance thresholds and laboratory methods are poorly defined for MET amplification, a targetable biomarker across malignancies.

Experimental Design:

The utility of next-generation sequencing (NGS) in assessing MET copy number alterations was determined in >50,000 solid tumors. Using fluorescence in situ hybridization as reference, we validated and optimized NGS analysis.

Results:

Incorporating read-depth and focality analyses achieved 91% concordance, 97% sensitivity, and 89% specificity. Tumor heterogeneity, neoplastic cell proportions, and genomic focality affected MET amplification assessment. NGS methodology showed superiority in capturing overall amplification status in heterogeneous tumors and defining amplification focality among other genomic alterations. MET copy gains and amplifications were found in 408 samples across 23 malignancies. Total MET copy number inversely correlated with amplified segment size. High-level/focal amplification was enriched in certain genomic subgroups and associated with targeted therapy response.

Conclusions:

Leveraging our integrated bioinformatic approach, targeted therapy benefit was observed across diverse MET amplification contexts.
To Rb or Not to Rb: Uncovering Unique Subsets of Small Cell Lung Carcinoma
Authors: Mahadevan Navin R. , Sholl Lynette M.
Published: August 2022

The use of IHC as a surrogate for specific underlying genomic alterations has allowed for increasingly comprehensive and accurate diagnosis of small cell lung carcinoma (SCLC). This is especially relevant in light of the increasing recognition of the biologic heterogeneity of this aggressive and difficult-to-treat lung tumor. Integrated genomic and IHC profiling of Rb status in SCLC yields new diagnostic insights and has translational implications.

See related article by Febres-Aldana et al., p. 4702
Persistent Facial Blanching after Botulinum Toxin Injection
Authors: Mitri Fouad , Kälber Katharina Anna , Enk Alexander H. , Toberer Ferdinand
Published: August 2022

We report the case of a 38-year-old male patient who presented with blanching of the face after strenuous exercise or physical exertion. The symptoms regressed in a relaxed state. Three years before presentation, he underwent botulinum toxin injections in the affected areas of the face. Facial blanching is a rare side effect of botulinum toxin injection. The postulated pathophysiology involves different transmitters mainly acetylcholine as well as co-transmitters implicated in vasodilation. Usually, facial blanching resolves shortly after waning of the botulinum toxin. However, in our case, the symptoms persisted for a longer time. Till date, therapy options for post-botulinum facial blanching are lacking, mainly due to the temporary aspect of the disease.
Risks of Single Fetal Demise after Laser for Twin-Twin Transfusion Syndrome
Authors: Gebb Juliana , Miller Kendra , Hwang Rosa , Soni Shelly , Paidas Teefey Christina , Didier Ryne , Oliver Edward R. , Rychik Jack , Moldenhauer Julie S. , Khalek Nahla
Published: August 2022

Introduction: The aim of the study was to determine if markers of donor placental insufficiency and recipient cardiac dysfunction increase the risk for single fetal demise (SFD) after laser for twin-twin transfusion syndrome (TTTS). Methods: Single-center retrospective review of patients who had laser for TTTS. Risk factors for donor and recipient demise within 1 week were compared in pregnancies with SFD and pregnancies with dual survival using χ2 or Fisher’s exact test. Multivariate logistic regression was then performed. Results: Of 398 procedures, 305 (76.6%) had dual survival, 36 (9.0%) had donor demise, 28 (7.0%) had recipient demise, and 9 (2.3%) had dual demise. The remaining 20 (5.0%) patients had complicated courses with pregnancy loss or further intervention. In the 64 pregnancies with SFD, 29 (81%) in the donor group and 20 (71%) in the recipient group occurred in the first postoperative week. For the donor demise group, estimated fetal weight (EFW) <10%, EFW <3%, EFW <1%, EFW discordance >25%, and EFW discordance >30% did not increase the risk for donor demise except in cases that also had umbilical artery absent or reversed end diastolic flow (AREDF). Donor AREDF was the only independent risk factor for early donor demise. For the recipient demise group, recipient abnormal venous Dopplers were associated with increased risk while EFW discordance >25% was associated with decreased risk of recipient loss. Discussion/Conclusion: In our cohort, donor growth restriction did not increase the risk of early donor demise after laser unless there was also donor AREDF. Donor AREDF was an independent risk factor for donor demise likely due to the severity of placental insufficiency. Abnormal recipient venous Doppler indices increased the risk of early recipient loss while a large intertwin discordance decreased the risk. This may be explained by profound overload in cases with recipient abnormal venous Doppler velocimetry and a lower risk of substantial fluid shifts from a relatively smaller donor territory when there is a large discordance.
Distinção e classe social no acesso ao ensino superior brasileiro
Authors: Moris Carlos Henrique Aparecido Alves , Casellato Fernando , Nascimento Matheus Monteiro , Agostini Gabriela , Massi Luciana
Published: August 2022

Este artigo tem como objetivo  estratificar e configurar as classes  sociais e suas distinções no acesso ao ensino superior brasileiro. A pesquisa adota técnicas estatísticas para investigar essas relações por meio dos dados do Exame Nacional do Ensino  Médio (Enem). Com base no capital cultural, econômico, social e  linguístico, identificamos uma classe superior que tem acesso a todos os cursos; uma classe intermediária heterogênea, cuja fração privilegiada tem acesso a 35,8% dos cursos, mas não aos de prestígio; e uma classe inferior, cujo baixo desempenho permite acesso a menos de 5% dos cursos. Assim, o Enem opera como um elemento que reproduz a  diferenciação e hierarquização, ao manter o ensino superior como uma distinção social.
Fragmentación ideológica de la elite en Chile
Authors: Gayo Modesto , Méndez María Luisa
Published: August 2022

Este artículo se titula “fragmentación ideológica de la elite en Chile”. Ofrece resultados de una investigación sobre los estratos más privilegiados de la sociedad chilena compuestos por empresarios, directivos y profesionales. En base a literatura sociológica y politológica, se indaga sobre la división política de las clases altas y medias altas. Para ello, se emplea una aproximación metodológica que combina técnicas cuantitativas (análisis de correspondencias múltiples), cualitativas (entrevistas en profundidad) y una lectura geográfica (mapas). Se concluye que la elite chilena está fuertemente dividida en torno a los cambios que el país enfrenta, mostrando una fragmentación interna de acuerdo a la edad y sobre todo la ideología política.
Right-Wing Populism and Political Instrumentalization of Religion
Authors: Marchetti Rita , Righetti Nicola , Pagiotti Susanna , Stanziano Anna
Published: August 2022

The study investigates the online debate sparked by the political instrumentalization of religious symbols by right-wing populist leaders, taking as a case study the campaign communication of Matteo Salvini—leader of the Italian “Lega” party—in the run-up to the 2018 and 2019 general and European elections. Against the backdrop of theories on populism, religious publicization and politicization in a social media context, the research analyzes over 2,000 Facebook posts referring to Salvini and religion by using a mixed computational and qualitative method including semi-automated frame analysis and correspondence analysis. Results show that right-wing populism is capable of successfully appropriating religious symbols and setting the agenda for religious topics on social media, even challenging the authority of traditional religious authorities on their own ground. By attacking the Church, defending the religious sentiment of the people, and opposing Christian identity to Islam, religion is effectively integrated into the populist worldview.
Environmental Personhood as a Landscape Planning Tool
Authors: Buława Piotr , Buława Bartłomiej , Borsa Maciej
Published: August 2022

In the face of increasing human impact on the environment, it is necessary to look for new tools for sustainable landscape planning. One of them may be the institution of environmental personhood. The conducted studies based on an analysis of legal texts show that environmental personhood has evolved into a more complex institution. Increasing emphasis is placed on the intangible, cultural, and even spiritual aspects of granting legal personality to natural objects. The first implementations of environmental personhood in Ecuador, Bolivia, Australia, and India did not concern landscape, but the other cases in Colombia, New Zealand, and Canada did and have features typical of a landscape planning tool.
Classes nominales dans deux langues Niger-Congo : le baïnouck djifanghorois (atlantique) et le koalib (kordofanien)
Authors: Quint Nicolas
Published: August 2022

Koalib (Kordofanian, Central Sudan) and Djifanghor Nyun (Atlantic, Senegal) are two Niger-Congo languages, both of which exhibit rich noun class systems controlling various morphological concord patterns. In this paper, I will study in turn the main characteristics of each of these class systems by taking into account the following criteria: form of the class markers, agreement targets, interaction with number, semantics, class derivation, exceptions and integration of loanwords. I will then discuss the interest and significance of this comparison, bearing in mind the fact that the inclusion of both Nyun and Koalib into the Niger-Congo language family is largely due to the existence of these class systems.
The Netherlands, the EU and the Israeli-Palestinian Conflict
Authors: Malcontent Peter
Published: August 2022

This historical study assesses the determining factors behind the development of the Netherlands as one of Israel’s most faithful European allies in its conflict with the Palestinians. As such it wants to contribute to the academic debate on foreign policy Europeanisation that started two decades ago with the publication of Ben Tonra’s seminal study on The Europeanisation of National Foreign Policy. Comprehensive studies using primary sources of the EU’s individual member states’ policies towards the Israeli-Palestinian conflict continue to be scarce. This study about the Netherlands contributes to filling this gap. It first sets out why the Dutch government’s position has always been more pro-Israel compared to that of the EU by assessing the relative influences of the EU and the Netherlands’ national Parliament as external and internal foreign policy determinants. After having established the dominating role of Dutch Parliament the latter part of this article tries to explain what continues to motivate a right-wing majority in Dutch Parliament to protect the Dutch government’s traditional pro-Israel position against external influences from the European level.
A new species of Tmesiphorus LeConte from northern Myanmar (Coleoptera: Staphylinidae: Pselaphinae)
Authors: YIN ZI-WEI
Published: August 2022

A new species of the pselaphine genus Tmesiphorus, T. shihongliangi sp. nov., is described and illustrated from Kachin State, North Myanmar, and is compared with and separated from allied congeners.
Trends in the Management of Non-emergent Surgery for Diverticular Disease and the Impact of Practice Parameters
Authors: Ore Ana Sofia , Allar Benjamin G. , Fabrizio Anne , Cataldo Thomas E. , Messaris Evangelos
Published: August 2022

Background

Due to the rise in diverticular disease, the ASCRS developed practice parameters to ensure high-quality patient care. Our study aims to evaluate the impact of the 2014 practice parameters on the treatment of non-emergent left-sided diverticular disease.

Methods

This is a retrospective cohort study using the ACS-National Surgical Quality Improvement Project (ACS-NSQIP). Elective sigmoid resections performed by year were evaluated and compared before and after practice parameters were published.

Results

Overall, 46,950 patients met inclusion criteria. There was a significant decrease in the number of non-emergent operations when evaluating before and after guideline implementation ( P < .001). There was a significant decrease in the number of patients younger than 50 years of age operated electively for diverticular disease (25.8% vs. 23.9%, P = .005). Adoption of minimally invasive surgery continued to increase significantly throughout the study period.

Conclusions

Publication of the 2014 ASCRS practice parameters is associated with a change in management of diverticular disease in the non-emergent setting.
Total Pelvic Exenteration Combined With Sacral Resection for Rectal Cancer
Authors: Komori Koji , Tsukushi Satoshi , Yoshida Masahiro , Kinoshita Takashi , Sato Yusuke , Ouchi Akira , Ito Seiji , Abe Tetsuya , Misawa Kazunari , Ito Yuichi , Natsume Seiji , Higaki Eiji , Asano Tomonari , Okuno Masataka , Fujieda Hironori , Oki Satoshi , Aritake Tsukasa , Tawada Kakeru , Akaza Satoru , Saito Hisahumi , Narita Kiyoshi , Hiroki Kawabata , Yasui Kohei , Shimizu Yasuhiro
Published: August 2022

Background

This retrospective study aimed to demonstrate surgical operative approach of total pelvic exenteration combined with sacral resection with rectal cancer and elucidate the relationships between the level of sacral resection and short-term outcomes.

Methods

Twenty cases were selected. Data regarding sex, age, body mass index, neoadjuvant therapy, location of sacral resection (“Upper” or “Lower” relative to the level between the 3rd and 4th sacral segment), operative time, bleeding, and curability (R0/R1) were collected and compared to determine their association with complications exhibiting a Clavien-Dindo grade III.

Results

The complication rate was significantly higher for recurrent cancers (n = 10, 76.9%) than for primary cancers (n = 1, 14.3%) ( P = .007), and for “Upper” resection (n = 8, 72.7%) than for “Lower” resection (n = 3, 33.3%) ( P = .078). Significant differences were observed when complication rates for “Lower” and primary cancer resection (n = 3, .0%) were compared between “Upper” and recurrent cancers (n = 8, 100.0%) ( P = .007).

Conclusion

In patients with recurrent rectal cancer, “Upper” sacral resection during total pelvic exenteration is associated with a high complication rate, highlighting the need for careful monitoring.
Failure behavior of laminated composite plates under anticlastic bending
Authors: Alpay Yakup O , Oz Fatih E , Sonmez Fazil O , Cinar Kenan
Published: August 2022

In this study, the failure behavior of laminated composite plates subjected to anticlastic bending is investigated. Anticlastic bending is a special case of bi-axial out-of-plane loading that produces predominantly twisting moment. A test fixture is designed to actualize anticlastic loading condition. Carbon-fiber-reinforced epoxy composite is selected as the material of the specimens. Totally nine different layup configurations are chosen and at least four specimens are tested for each configuration. Acoustic emission monitoring (AEM) is utilized to detect the first-ply-failure load and the accumulation of damage in the laminates. In this method, elastic waves resulting from initiation and progression of damage are detected, and then AE signals are processed to identify the failure modes and determine the first-ply-failure load. A finite element model is developed to simulate the anticlastic bending test. A code is developed using ANSYS parametric design language to predict the first-ply-failure loads using various failure criteria like Tsai–Wu, Hashin, and Puck. The experimental and numerical results are then compared. Relative strengths and weaknesses of the failure criteria in estimating failure of laminated composite plates under anticlastic bending are discussed.
Predictors of infrapopliteal vein bypass graft revision in patients with chronic limb-threatening ischemia
Authors: Kawai Yohei , Kodama Akio , Sato Tomohiro , Ikeda Shuta , Tsuruoka Takuya , Sugimoto Masayuki , Niimi Kiyoaki , Banno Hiroshi , Komori Kimihiro
Published: August 2022

Purpose

Surgical revascularization is the standard treatment for chronic limb-threatening ischemia (CLTI). However, some patients may require reintervention. The Global Anatomic Staging System (GLASS), which evaluates the complexity of infrainguinal lesions, was proposed. This study aimed to identify predictors for graft revision and evaluate whether GLASS impacts vein graft revision.

Methods

Between 2011 and 2018, CLTI patients who underwent de novo infrapopliteal bypass using autogenous veins were retrospectively analyzed. To assess anatomic complexity with GLASS, femoropopliteal, infrapopliteal, and inframalleolar/pedal (IM) disease grades were determined. The outcomes of patients with or without graft revision were compared. Cox regression analysis was performed.

Results

Thirty-six of the 80 patients underwent reintervention for graft revision. Compared to the non–graft revision group, the graft revision group exhibited significantly higher rates of GLASS stage III (66% vs 81%, p = 0.046) and grade P2 IM disease (25% vs 58%, p = 0.009). Multivariate analysis revealed that IM grade P2 (hazard ratio [HR], 3.35; 95% confidence interval [CI], 1.66–6.75; p = 0.001) and spliced vein grafts (HR, 3.18; 95% CI, 1.43–7.06; p = 0.005) were significantly associated with graft revision.

Conclusions

This study demonstrated that IM grade P2 and spliced vein grafts were predictors of graft revision. The GLASS stratification of IM disease grade may be useful in optimizing treatment for CLTI.
Increased incidence of hematologic malignancies in SCD after HCT in adults with graft failure and mixed chimerism
Authors: Lawal Rialnat A. , Mukherjee Devdeep , Limerick Emily M. , Coles Wynona , Hsieh Matthew M. , Dillon Laura W. , Hourigan Christopher S. , Fitzhugh Courtney D.
Published: August 2022

Lawal et al report on a 45-fold increase in secondary hematologic malignancy in 120 patients following hematopoietic stem cell transplantation (HSCT) for sickle cell disease (SCD), comparable to what has been reported following gene therapy. Notably, the cohort is enriched for older patients and for haploidentical transplant recipients with mixed chimerism following HSCT. These data further support the idea that pre-existing premalignant myeloid clones undergo clonal selection in the setting of nonmyeloablative HSCT and contribute to secondary malignancy.
Different rhizosphere soil microbes are recruited by tomatoes with different fruit color phenotypes
Authors: Chen Siyu , Sun Yan , Wei Yufei , Li Huan , Yang Shangdong
Published: August 2022

Background

To explore and utilize abundant soil microbes and their beneficial functions, the bacterial and fungal compositions in rhizospheres between red- and yellow-fruited tomato varieties were analyzed using high-throughput sequencing technique.

Result

Our results indicated that different soil microbes in rhizospheres of tomatoes were exactly recruited by different color fruit tomatoes. For the reasons as not only soil bacterial community, but also soil fungal compositions were all different between red and yellow fruit tomatoes. For example, Nocardioides, norank_f_norank_o_Vicinamibacterales, norank_f_norank_o_norank_c_KD4-96, norank_f_Birii41, norank_f_norank_o_S085 and Bradyrhizobium were the specific dominant soil bacterial genera, and Lecythophora, Derxomyces and unclassified_f_Pyronemataceae were the dominant soil fungal genera in the rhizospheres of red tomato varieties. By contrast, unclassified_f__Micromonsporaceae, Acidipila, Roseisolibacter, Gaiella and norank_f_Xanthobacteraceae were the unique dominant soil bacterial genera in the rhizospheres of yellow tomato varieties. And unclassified_o__Onygenales, Trichocladium, unclassified_c__Sordariomycetes, Pseudogymnoascus, Acremonium, Oidiodendron, Phialemonium, Penicillium, Phialosimplex were the unique dominant soil fungal genera in rhizospheres of yellow tomato varieties. Moreover, a higher abundance of specific soil bacterial and fungal genera in the rhizosphere was found in rhizospheres of the yellow than those of the red tomato varieties.

Conclusion

Soil bacterial and fungal compositions in rhizospheres between red- and yellow-fruited tomato varieties were found significantly different which growing in the same environment under the identical managements. It suggested that different soil microbes in rhizospheres exactly were recruited by different phenotypes tomato varieties related to fruit color formation.
The combined effects of physical frailty and cognitive impairment on emergency department- versus direct-admission hospitalizations
Authors: Buta Brian , Friedman Ari B. , Chung Shang-En , Sheehan Orla C. , Blinka Marcela D. , Gearhart Susan L. , Xue Qian-Li
Published: August 2022

Background

We aimed to study whether physical frailty and cognitive impairment (CI) increase the risk of recurrent hospitalizations in older adults, independent of comorbidity, and disability.

Methods

Two thousand five hundred forty-nine community-dwelling participants from the National Health and Aging Trends Study (NHATS) with 3 + years of continuous Medicare coverage from linked claims data were included. We used the marginal means/rates recurrent events model to investigate the association of baseline CI (mild CI or dementia) and physical frailty, separately and synergistically, with the number of all-source vs. Emergency Department (ED)-admission vs. direct admission hospitalizations over 2 years.

Results

17.8% of participants had at least one ED-admission hospitalization; 12.7% had at least one direct admission hospitalization. Frailty and CI, modeled separately, were both significantly associated with risk of recurrent all-source (Rate Ratio (RR) = 1.24 for frailty, 1.21 for CI; p < .05) and ED-admission (RR = 1.49 for frailty, 1.41 for CI; p < .05) hospitalizations but not direct admission, adjusting for socio-demographics, obesity, comorbidity and disability. When CI and frailty were examined together, 64.3% had neither (Unimpaired); 28.1% CI only; 3.5% Frailty only; 4.1% CI + Frailty. Compared to those Unimpaired, CI alone and CI + Frailty were predictive of all-source (RR = 1.20, 1.48, p < .05) and ED-admission (RR = 1.36, 2.14, p < .05) hospitalizations, but not direct admission, in our adjusted model.

Conclusions

Older adults with both CI and frailty experienced the highest risk for recurrent ED-admission hospitalizations. Timely recognition of older adults with CI and frailty is needed, paying special attention to managing cognitive impairment to mitigate preventable causes of ED admissions and potentiate alternatives to hospitalization.
Perioperative stroke during carotid endarterectomy: benefits of multimodal neuromonitoring - a case report
Authors: Michels D. M. , Van Dijk L. C. , Tavy D. L. J.
Published: August 2022

Background

Carotid endarterectomy is routinely performed after ischemic stroke due to carotid stenosis. Perioperative, cerebral blood flow and oxygenation can be monitored in different ways, but there is no clear evidence of a gold standard and a uniform guideline is lacking. Electroencephalography and near-infrared spectroscopy are among the most frequently used methods of neuromonitoring. Clinicians should be aware of their pitfalls and the added value of transcranial doppler.

Case presentation

We present the case of an 85-year old male with perioperative haemodynamic stroke during carotid endarterectomy. Ischemic stroke was caused by suddenly increased carotid stenosis resulting in major neurologic deficit. This was registered only by transcranial doppler, while surface electroencephalography and near-infrared spectroscopy failed to detect any significant change in cerebral perfusion, despite a large perfusion defect on computed tomography. Circulation was restored with endovascular treatment and neurologic deficit quickly resolved.

Conclusion

We strongly advocate the practice of multimodal neuromonitoring including transcranial doppler whenever possible to minimize the risk of persistent neurologic deficit due to perioperative stroke during carotid endarterectomy.
Trends and determinants of pregnancy loss in eastern Ethiopia from 2008 to 2019: analysis of health and demographic surveillance data
Authors: Regassa Lemma Demissie , Tola Assefa , Daraje Gamachis , Dheresa Merga
Published: August 2022

Background

Pregnancy losses remain a neglected issue and it will be taking more than a century before a pregnant woman in Sub Sahara has the same chance of her baby being born alive as a woman in a high-income country. Pregnancy loss data are limited and not universal in Sub Saharan countries. This study was aimed to assess the magnitude and determinants of pregnancy loss in eastern Ethiopia.

Methods

This study was conducted in, open continues and dynamic cohort of population, Kersa Health and Demographic Survillance site (HDSS) in Eastern Ethiopia in 2008–2019. All mothers who had known pregnancy outcomes during the period and reside in Kersa HDSS were considered. The prevalence proportions were calculated as the sum of all pregnancy loss divided by the number births in the specified year. Log-Binomial regression was used to determine factors associated with pregnancy loss. Prevalence Proportion Ratio (PPR) was used to report the magnitude and strength of association. A p-value of less than 0.05 was considered statistically significant.

Results

From 39,153 included pregnancies, 810 (20.7; 95%CI:19.32, 22.15 per 1000 births) experienced pregnancy loss. Stillbirth was higher than abortion (11.14 Vs. 9.55 per 1000 births). Lacking own income (aPPR:1.26; 95%CI: 1.01, 1.58), being daily laborer (aPPR:1.44; 95%:1.08, 306) history of previous pregnancy loss (aPPR:2.26, 95%CI:1.69, 3.03), unwanted pregnancy (aPPR:1.26; 95%CI:1.01, 1.80), not receiving antenatal care (aPPR:1.59; 95%CI: 1.19, 2.13) and not receive the TT-vaccine during pregnancy (aPPR:1.33; 95%CI: 1.08, 1.80) were positively associated with pregnancy loss.

Conclusions

The overall rate pregnancy loss was ranged between 19.32, 22.15 per 1000 births with higher still births than miscarriage or abortion. Pregnancy loss was positively associated with social factors reproductive health factors, and maternal health service utilization.
Distance is “a big problem”: a geographic analysis of reported and modelled proximity to maternal health services in Ghana
Authors: Dotse-Gborgbortsi Winfred , Nilsen Kristine , Ofosu Anthony , Matthews Zoë , Tejedor-Garavito Natalia , Wright Jim , Tatem Andrew J.
Published: August 2022

Background

Geographic barriers to healthcare are associated with adverse maternal health outcomes. Modelling travel times using georeferenced data is becoming common in quantifying physical access. Multiple Demographic and Health Surveys ask women about distance-related problems accessing healthcare, but responses have not been evaluated against modelled travel times. This cross-sectional study aims to compare reported and modelled distance by socio-demographic characteristics and evaluate their relationship with skilled birth attendance. Also, we assess the socio-demographic factors associated with self-reported distance problems in accessing healthcare.

Methods

Distance problems and socio-demographic characteristics reported by 2210 women via the 2017 Ghana Maternal Health Survey were included in analysis. Geospatial methods were used to model travel time to the nearest health facility using roads, rivers, land cover, travel speeds, cluster locations and health facility locations. Logistic regressions were used to predict skilled birth attendance and self-reported distance problems.

Results

Women reporting distance challenges accessing healthcare had significantly longer travel times to the nearest health facility. Poverty significantly increased the odds of reporting challenges with distance. In contrast, living in urban areas and being registered with health insurance reduced the odds of reporting distance challenges. Women with a skilled attendant at birth, four or more skilled antenatal appointments and timely skilled postnatal care had shorter travel times to the nearest health facility. Generally, less educated, poor, rural women registered with health insurance had longer travel times to their nearest health facility. After adjusting for socio-demographic characteristics, the following factors increased the odds of skilled birth attendance: wealth, health insurance, higher education, living in urban areas, and completing four or more antenatal care appointments.

Conclusion

Studies relying on modelled travel times to nearest facility should recognise the differential impact of geographic access to healthcare on poor rural women. Physical access to maternal health care should be scaled up in rural areas and utilisation increased by improving livelihoods.
The pilot project of the National Cancer Network in Poland: Assessment of the functioning of the National Cancer Network and results from quality indicators for lung cancer (2019–2021)
Authors: Trembecki Łukasz , Sztuder Aleksandra , Dębicka Izabella , Matkowski Rafał , Maciejczyk Adam
Published: August 2022

Background

This analysis presents the outcomes of the operations of the National Cancer Network (NCN) pilot project in Lower Silesian Voivodeship, Poland, for lung cancer for the period of 2019–2021. The results concerning measures of the quality of medical processes were analysed.

Methods

Twenty-one measures used to gauge the quality of oncological care for lung cancer were assessed. Data collection and processing for the purpose of calculating the measures were carried out as part of the NCN pilot project based on the Regulation of the Ministry of Health enacted on 13 December 2018. The measures were calculated at the Voivodeship Coordination Center, and the data were derived from the centres included in the network in the area of the analysed voivodeship.

Results

A total of 3,638 patients diagnosed with lung cancer were enrolled in the NCN pilot program during the analysed period. For 3 measures, out of 21, target values were obtained. For 2 measures, the values differed significantly from the assumed target value.

Conclusion

In our opinion, the NCN pilot study, as a test of the network’s functioning, meets the assumed goal. The NCN assessment is based on, inter alia, analysis of the outcomes of oncological quality of care measures for lung cancer, and facilitates monitoring of the quality of medical services provided and the identification of areas for improvement. In addition, the pilot program, which will last until the end of 2022, will allow for further in-depth analysis regarding the network’s limitations before implementing the system on a national scale in Poland. This will be the subject of further investigation.
The differences of serum lipid profiles between primary aldosteronism and essential hypertension: a meta-analysis and systematic review
Authors: Manosroi Worapaka , Phudphong Pitchaporn , Atthakomol Pichitchai , Phimphilai Mattabhorn
Published: August 2022

Background

The data on lipid profile differences between primary aldosteronism (PA) and essential hypertension (EH) patients are inconsistent and inconclusive. Most studies reported lower levels of lipid profiles in PA than in EH. This meta-analysis aimed to explore differences in serum lipid profiles including triglyceride (TG), total cholesterol (TC), LDL and HDL levels in PA patients and EH patients.

Methods

A search of published studies was performed using PubMed, Embase and Scopus databases from their inception through August 2022. Thirty studies involving 11,175 patients were identified. Inclusion criteria included 1) observational studies which contained data on any of the lipid profiles of interest (TG, TC, LDL and HDL) which could be acquired from baseline data or the outcomes, 2) data which should be compared between adult PA and EH patients and 3) the use of appropriate methods to diagnose PA. Standardized mean difference (SMD) with a 95% confidence interval (95% CI) was calculated to assess effect size by using STATA program version 15.0. Risk of bias was assessed by Joanna Briggs Institute (JBI) Critical Appraisal Tools for cross-sectional, cohort and case-control studies.

Results

Levels of the lipid parameters TG (SMD − 0.16 mmol/L; 95%CI (− 0.25, − 0.07)), TC (SMD − 0.30 mmol/L; 95%CI (− 0.41, − 0.19)) and LDL (SMD − 0.17 mmol/L; 95%CI (− 0.27, − 0.08)) were significantly lower in PA than in EH patients. There was no statistically significant difference in HDL between PA and EH patients (SMD − 0.08 mmol/L; 96%CI (− 0.23,0.07)). High levels of heterogeneity for TG, TC, HDL and LDL were observed in all studies. Risk of bias among the studies was low to moderate.

Conclusion

Lower levels of TG, TC and LDL were observed in PA than in EH patients. Further study should be conducted to address the underlying mechanisms of lipid alteration in PA.
Whole-transcriptome analysis of periodontal tissue and construction of immune-related competitive endogenous RNA network
Authors: Zhao Quanquan , Wen Jing , Ouyang Xiangying , Liu Jianru , Liu Wenyi , Zhang Shengnan , Lv Peiying , Lou Xinzhe
Published: August 2022

Background

In periodontitis, noncoding RNAs may play a regulatory role in the immune microenvironment through competitive endogenous RNA. We aimed to profile noncoding RNA expression and construct immune-related ceRNA network in periodontitis.

Methods

Five inflamed periodontal tissue and five healthy gingivae were collected for whole-transcriptome sequencing. Differential gene, functional enrichment, and protein–protein interaction network analysis were performed to explore the function of differentially expressed genes. CIBERSORTx was used to analyze level of immune cell infiltration in the periodontal tissue. An immune-related competitive endogenous RNA network was constructed and expression of key regulators in the network was validated.

Results

Compared with healthy gingiva, 200 mRNAs, 90 long noncoding RNAs, 65 microRNAs, and 518 circular RNAs were differentially expressed, and cell chemotaxis was significantly enhanced in inflamed periodontal tissue. Immune cell infiltration analysis showed that neutrophils, macrophages M1, T follicular helper cells, and naive B cells were significantly increased in periodontitis. Key regulators including JUN, FOS, THBS1, KLF2, WIF1, were identified and their expression was then validated.

Conclusion

We constructed an immune-related competitive endogenous RNA network in periodontal tissue, which provided new insights into immune homeostasis in periodontitis and laid a foundation for further study of noncoding RNAs. Key regulators in this network may be promising targets for future periodontitis treatment.
“I want to live, but …” the desire to live and its physical, psychological, spiritual, and social factors among advanced cancer patients: evidence from the APPROACH study in India
Authors: Joad Anjum S. Khan , Hota Arati , Agarwal Pratima , Patel Krimal , Patel Kinjal , Puri Jyotika , Shin Soye
Published: August 2022

Background

The limited access to palliative care resources along with the social stigma around cancer largely explains the poor quality of life (QoL) of Indian advanced cancer patients. As advanced cancer patients with poor QoL often harbour a desire for hastened death (DHD), it is imperative to understand factors affecting DHD, or the desire to live (DTL) among advanced cancer patients in India. We aim to examine the relationship between DTL and physical, psychological, spiritual, and social factors measuring patients’ QoL alongside their awareness of their late cancer stage.

Methods

We surveyed 200 patients from a tertiary cancer hospital in India to collect their DTL, awareness of cancer stage, demographic characteristics, and standardized measures for patients’ QoL. We used a linear probability regression model to quantify the association between these factors and patients’ DTL among the final sample of 192 patients with no missing information for the variables of interest.

Results

Among the various domains affecting cancer patients’ QoL, we found that the pain severity score (ranging from 0 to 10) and psychological distress score (ranging from 0 to 42) are negatively associated with the DTL. One point increase in each score reduced the DTL by 2.2% (p < 0.05) and 0.7% (p < 0.05), respectively. Our results also showed that patients whose perceived socio-economic status (SES) is poor have a 16% (p < 0.05) lower probability of DTL, compared to those with higher SES (lower middle class, upper middle class, and wealthy). Controlling for caste, religion, gender, age, marital status and years of education, we found psychological distress is statistically higher among patients belonging to this bottom SES.

Conclusions

We found that pain severity, psychological distress and perceived low SES are negatively associated with the desire to live in advanced cancer patients. Future research should focus on developing interventions to improve physical pain and psychological distress, particularly for patients who are socially and economically disadvantaged.