bluuebunny/crossref_metadata_2025 huggingface dataset:
The Transcendence of Psychedelic Rock as a Phenomenon of the Mass Musical Culture of Great Britain and the USA of the 1960s and 1970s
Authors:   Ural Federal University, Maukin Vsevolod R.
Published: June 2022

The paper discusses transcendental trends in psychedelic rock music in the USA and Great Britain of the 1960s and 1970s. The reasons for the interest in altered states of consciousness among young people in the designated era are investigated. The main features of psychedelic rock are emphasized: its harmonic, rhythmic and timbral features, as well as recording techniques and the theme of songs.
The effect of stirrup spacing and hook angle on RC cantilever beams with iron chip waste
Authors: Ozyurt Muhammet Zeki , Sancak Omer Fatih
Published: June 2022

In this study, the usability of industrial iron chip waste was investigated to carry out recycling in the production of reinforced concrete (RC) cantilever beams with different stirrup spacings and hook angles. In the concrete produced for cantilever beams, aggregates no larger than 4 mm diameter were reduced by 20% and replaced with iron chip waste. Cantilever beams were manufactured with stirrup spaces of 50, 100 and 150 mm. The hook angles of the stirrups were differentiated to be 90 and 135°. The experimental set-up was prepared in such a way that one side of the samples was fixed and the other side was free. Load–displacement curves of cantilever beams were obtained. In the research, it was observed that although cantilever beams with 20% iron chips experienced a decrease in their strength compared with the reference beams, they increased their ductility values at all three different stirrup spaces. As the stirrup spacing widened, the ductility values decreased. However, the effect of iron chip additives on ductility increased. Samples with a stirrup hook angle of 135° increased in both strength and ductility values compared with samples with a stirrup hook angle of 90°.
‘Responsible Body’: Menstrual Education Films and Sex Education in the United States and Scotland, 1970s–1980s.
Authors: Ghanoui Saniya Lee
Published: June 2022

The provision of menstrual products for free has become one part of the larger push by menstrual activists to make menstrual equity a global priority. Menstrual equity includes addressing and solving concerns that connect menstruation to public health issues, gender equality, and access to complete and comprehensive health and menstrual education. This last point is the focus of this paper. The Period Products (Free Provision) (Scotland) Bill in Scotland did not emerge out of nowhere; neither did legislation across the US that addresses period poverty. Rather, these legal advances are the latest in a complicated and complex fight for menstrual education and healthcare. The Period Products Act’s emphasis on ‘access’—access to education and to menstrual products—is rooted in Scottish sex and menstrual education. This seemingly subtle difference from American menstrual education reveals how access has historically been integrated into Scottish menstrual education, a comparison particularly visible in the American and Scottish films studied here, Naturally … a Girl (1973) and Having a Period: Menstruation (1980), respectively.
İnançların Gökkuşağı: Dinsel Çoğulculuk Üzerine Eleştirel Diyaloglar
Authors: Taşdemir Tuğba
Published: June 2022

John Hick, New York’taki Union Theological Seminary’de verilen Auburn Konferanslarının bir versiyonu olan bu çalışmasında, dinsel çoğulculukla ilgili ileri sürdüğü argümanların yol açtığı yaklaşık 30 yıldır yapılan eleştirileri, felsefi ve teolojik itirazlara değinen filozof Phil ve teolog Grace ile karşılıklı diyaloglar şeklinde yanıtlar. Kitabın kapağı, bütün dünya dinlerini Aşkın Gerçekliğe yönelik onu kavramada, deneyimlemede ve O’na karşılık vermede eşit geçerli yollar olarak kabul eden dinsel çoğulculuk anlayışıyla ilgili ipuçları taşır. Hick’in ifadesiyle, güneşin ışıklarının yeryüzü atmosferi tarafından muhteşem bir tayfa dönüştürülmesi gibi gökkuşağı da İlahi ışığın bizim beşeri kültürlerimiz tarafından yansıtılmasını ifade eden bir metafordur.
IC50: an unsuitable measure for large-sized prostate cancer spheroids in drug sensitivity evaluation
Authors: Xu Yipeng , Pachnikova Gabriela , Wang He , Wu Yaoyao , Przybilla Dorothea , Schäfer Reinhold , Chen Zihao , Zhu Shaoxing , Keilholz Ulrich
Published: June 2022

Preclinical models of tumors have the potential to become valuable tools for commercial drug research and development, and 3D culture systems are gaining attraction in this area, including prostate cancer (PCa) research. However, nearly all 3D drug design and screening assessments are based on 2D experiments, indicating the limitations of 3D drug testing. To simulate the natural response of human cells to the drug, we detected the half-maximal inhibitory concentration (IC50) changes of 2D/3D LNCaP cells to the drug docetaxel and the sensitivity of different morphologies of 2D/3D LNCaP to docetaxel treatment. In contrast to 2D LNCaP cells, the evaluation of the susceptibility of LNCaP spheroids to treatment was more complicated. The fitness of IC50 curves of 2D and 3D tumor cell preclinical models differed significantly. IC50curves were unsuitable for large LNCaP spheroids. More evaluation indexes (e.g., maximal inhibition) and experiments (e.g., spheroids formation) should be explored and performed to systematically evaluate the susceptibility.
Challenges in School‐To‐Work Transition in Germany and Austria: Perspectives on Individual, Institutional, and Structural Inequalities
Authors: Schels Brigitte , Wöhrer Veronika
Published: June 2022

Transitions between schools, vocational education and training (VET), and work pose important challenges for young people that influence their well‐being and social positioning now and in the future. The young people themselves experience the transition phase as the formation stage of their aspirations and goals. In this process, young people are confronted with the expectations and assessments of relevant others—such as parents, teachers, employers, and career counsellors—and by the requirements that are defined in sociopolitical and institutional contexts. In these contexts, criteria of successful transitions and risky transitions worthy of special support are made relevant. German and Austrian employment-centred transition regimes are characterised by relatively high standardisation and segregation as well as a strong VET system linked to the labour market. This thematic issue brings together contributions that examine challenges in these transitions from different perspectives and related facets of social inequality. The articles address different transitions (mostly school‐to‐VET, but also school‐to‐school or unemployment to work) and their different phases: aspiration formation, changing aspirations, challenges in transitions, and concrete problems in transition processes like disconnectedness or unemployment. The articles on social inequalities are related to class, ethnicity, gender, and (dis)ability. We also place importance on balancing different methods to bring together findings from quantitative surveys, qualitative interviews, and participatory research.
Pushing Higher or Lower? Divergent Parental Expectations and Compromises in Occupational Choice
Authors: Fischer-Browne Melanie
Published: June 2022

Many adolescents in Germany are unable to realize their realistic occupational aspirations when they transition from school to vocational education and training (VET). However, little is known about the underlying circumstances and what the compromises look like when these adolescents come to take up a VET occupation. As parents perform an important socialization role, which is also influential in occupational orientation, this article examines the role of divergent parental expectations. Are parental expectations, which differ from adolescents’ realistic occupational aspirations, related to the probability that adolescents will take up different occupations than they originally aspired to? Are relatively higher or lower parental expectations associated with a corresponding direction of compromise formation? Are there differences between men and women in the relationship between divergent parental expectations and compromise formation? This empirical analysis is based on a sample of 1243 VET entrants from the starting cohort 4 of the National Educational Panel Study (NEPS). The compromise formation of the adolescents is measured by comparing their realistic occupational aspirations from ninth grade with their first VET occupation. Results from multinomial logistic regression models show that adolescents adjust their occupational choices to their parents’ divergent expectations. Women are more likely to make compromises that accommodate their parents’ higher expectations.
Chaotic-Based Encryption Algorithm using Henon and Logistic Maps for Fingerprint Template Protection
Authors: Siswanto Apri
Published: June 2022

Fingerprint is a reliable user authentication method as it is unique to individual users that makes it efficient for authenticating users. In a fingerprint authentication system, user fingerprint information is stored in databases in an image format known as a fingerprint template. Although fingerprint is reliable, the templates stored in the database are exposed to security threats either during the data transmission process over the network or in storage. Therefore, there is a need to protect the fingerprint template, especially in unsecured networks to maintain data privacy and confidentiality. Many past studies proposed fingerprint template protection (FTP) using chaotic-based encryption algorithms that are more suitable to secure images than conventional encryption such as DES, AES, and RSA. The chaotic-based encryption algorithms have been improved a lot in terms of their robustness. However, the robustness of the algorithm caused a trade-off to encryption speed where it remains an issue in FTP.  Hence, this study aims to improve the limitations found in the existing chaotic-based encryption algorithms for FTP by improving its encryption speed using Henon and Logistic map. A series of simulations were conducted using MATLAB to evaluate the performance of the proposed chaotic-based encryption algorithm for FTP through different analyses covering key sensitivity, histogram, correlations, differential, information entropy, and encryption/decryption speed. The performance proposed encryption algorithm was promising which could be a starting point for detailed analysis and implementation in real application domains.
ANALYSIS OF THE RELATIONSHIP BETWEEN THE QUALITY OF HEALTH SERVICES DIMENSIONS AT THE TERTIARY LEVEL OF HEALTHCARE
Authors:   University of Tuzla, Faculty of Economics, Brajić Aldin , Dedić Samira , Brajić Saliha
Published: June 2022

Tercijarna razina zdravstvene zaštite trebala bi pružati visokospecijaliziranu zdravstvenu uslugu koja uključuje najsloženije metode i postupke dijagnostike, liječenja i rehabilitacije. U skladu s time, kvaliteta usluga na ovoj razini zdravstvene zaštite trebala bi biti na najvišoj razini, a menadžeri bi trebali posjedovati i provoditi sustav upravljanja kvalitetom. Cilj rada je ispitati povezanost dimenzija kvalitete zdravstvenih usluga na tercijarnoj razini zdravstvene zaštite u Bosni i Hercegovini, mjereno iz perspektive korisnika zdravstvene zaštite. Središnja hipoteza glasi: „Postoji statistički značajna povezanost između dimenzija kvalitete zdravstvenih usluga na tercijarnoj razini zdravstvene zaštite Bosne i Hercegovine.“ Istraživanje je provedeno anketnim putem na stratificiranom uzorku od 1022 korisnika zdravstvenih usluga svih pet tercijarnih kliničkih centara na području BiH. Istraživanjem je utvrđena statistički značajna korelacija između promatranih dimenzija kvalitete zdravstvenih usluga: opipljivosti, pouzdanosti, odaziva, sigurnosti i empatičnosti. Dobivene rezultate klinički menadžment može koristiti za implementaciju sustava upravljanja kvalitetom i poboljšanje kvalitete zdravstvenih usluga.
Impact of high speed of vessels on narrow and shallow waterways with reference to the Adriatic Sea
Authors:   Faculty of Maritime Studies Rijeka, Komać Ante , Mohović Đani , Strabić Marko
Published: June 2022

Sudden increase of demand of high speed craft, especially fast passenger-cargo ferries and catamarans in the last few decades, has made it necessary to respond in a timely manner to the set of negative impacts that such vessels cause with high speeds near coastal areas. All relevant literature was investigated in this paper, as well as the reports, scientific articles by different databases, and collected data was evaluated by analyzing the content and mitigation measures by specific categories in order to emphasise the importance of potential negative effects of wakes. In addition to the mechanism of wake generation and physical characteristics of waves generated by vessels in coastal areas, a critical overview of the investigated impacts is presented, which includes: impact on safety (lives, vessels, structures), and environmental impact (hydro-morphological impact, impact on flora, fauna and cultural heritage). Particular attention is paid to the analysis and review of applied methods of risk assessment and adoption of measures in various countries where such research has already been conducted to a certain extent, in order to compile a set of effective recommendations that can be applied to reduce negative impacts. Since the previous researches mostly cover some impacts individually, it is also pointed out, among other recommendations, the importance of conducting concrete comprehensive coordinated research on this topic with an emphasis on the Adriatic Sea area, which is unique in multiple locations in terms of safety and environmental aspect, as well as in terms of the aspect of preserving the cultural heritage.
Determining the Trajectory of the Crane Block Using the Finite Element Method
Authors:   Polish Naval Academy, Faculty of Mechanical and Electrical Engineering, Gdynia, Poland, Grządziela Andrzej , Kiciński Radosław , Szturomski Bogdan , Piskur Paweł
Published: June 2022

The paper discusses determining crane block trajectories using the finite element method (FEM). The mathematical formulation for air resistance of hooks’ block is presented with kinematic analysis of the block. The three crane blocks are considered: without wind deflector, with a spherical deflector and a cylindrical fairing. The hook block was assumed as a physical pendulum. The FEM analysis is provided with the hook block movement consideration. Movement trajectories of hook blocks for different wind speeds is depicted and the results are. At the end of the paper, the conclusions are provided with the directions of future research.
The globalization of values: A comparison between Bangladesh and the USA
Authors: Khan Wahiduzzaman , Khan Md. Zakir Hossain
Published: June 2022

Globalization is creating similar environments for younger consumers around the world. With younger individuals being socialized in more similar environments than their parents, the former should have more comparable values than the latter. The goal of the current study was to empirically test this argument.

154 consumers served as voluntary subjects (84 from the USA and 70 from Bangladesh). Questionnaires were administered to respondents for gathering the necessary data.

The respondents ranged in age from 19 to 80. Based on data gathered from 120 subjects across two countries, the results support growing similarities in values between younger consumers in comparison to older consumers. These results suggest that marketers might be able to adopt standardized marketing practices with younger individuals, whereas standardization might not have been an option with their parents.

JEL Classification Code: D46, F01, M31
Does trade credit substitute bank credit during crisis period? A Review of recent literature
Authors: Rehman Shafiq ur
Published: June 2022

Although earlier studies on trade credit have made good progress and provided evidence that adds to our understanding of the role of trade credit they don’t reach a unanimous conclusion. This highlights a clear gap in the existing literature. The objective of this study is to fill the gap in the literature by providing an extensive review of the role of trade credit, especially during crisis periods.

Since this is a review paper, therefore it does not involve any econometric modeling or statistical methods for validating its claim. The method of this study is based on the interpretation of the results of existing studies. 

There is conflicting evidence regarding the role of trade credit during the crisis period. However, the currently dominant practice in finance is to view trade credit as a substitute for bank credit, especially for small firms. Since small firms face high market frictions and have limited access to market finance, therefore when rationed by banks during a financial crisis, these firms move towards high implicit cost trade credit to offset the reduction in bank credit.

This paper presents a review of the empirical literature on the use of trade credit for financing motives. Its aim is to provide an insight into whether trade credit serves as a substitute or complement during the crisis period. The review concludes that small firms face a high information problem. This information problem becomes worsens during an economic downturn or tight monetary conditions. As a consequence firm’s particularly small firms move towards trade credit to undo the bank lending channel.

JEL Classification Code: F17, F18, G01, M48
Teoría y práctica en la teoría política medioambiental
Authors: Lara de La Fuente Daniel
Published: June 2022

Es sabido que hay consenso científico sobre la existencia de problemas ecológicos que, de no ser abordados, pueden comprometer el futuro de las sociedades actuales. Para resolverlos, se requiere cambiar sustancialmente las relaciones entre naturaleza y sociedad. Esta necesidad ha sido remarcada por la denominada teoría política medioambiental. Sin embargo, las aportaciones de este campo no han cristalizado en las instituciones y las prácticas sociales. Este trabajo compara dos formas de acortar esta distancia entre teoría y acción medioambientales. Teniendo el Antropoceno como marco de análisis de las relaciones socionaturales, reivindica un papel activo de la teoría política en la provisión de conceptos y argumentos a otros actores en la esfera pública e institucional. Esta tesis se defiende de dos maneras. Primero, se argumenta que esto puede hacerse sin menoscabo de estándares lógicos y epistemológicos convencionales. Segundo, se muestran las deficiencias de otros actores propuestos para desempeñar esta tarea, centrándonos en los movimientos por la justicia medioambiental y los movimientos por la justicia climática.
Alianzas de nacionalismos: los vínculos del partido Vox con la derecha radical de Europa y Estados Unidos
Authors: Ballester Rodríguez Mateo
Published: June 2022

En el partido Vox ha existido desde su fundación un doble discurso. Por un lado, se ha destacado su carácter singular, tanto en las circunstancias que propician su existencia como en su idiosincrasia y planteamientos. Por otro lado, se ha ido afirmando e imponiendo un discurso que identifica como compartidos con otros partidos de derecha radical tanto su diagnóstico de las problemáticas que denuncia como las soluciones ofrecidas. Desde este planteamiento el partido ha desarrollado una amplia política de contactos y alianzas con otras formaciones. En este artículo se abordarán las influencias ejercidas por otras formaciones de derecha radical sobre un partido Vox en proceso de definición ideológica. Se argumentará asimismo que, una vez consolidado en el panorama político español, Vox ha centrado sus contactos en las formaciones con las que tiene un mayor grado de coincidencia en planteamientos considerados centrales desde el partido, abandonado una previa política escasamente selectiva al respecto. Se estudiarán de forma individualizada las referencias internacionales más intensas de Vox, en buena medida ordenadas por su creciente relevancia en ese sentido. Estos contactos y alianzas suponen en cualquier caso una colaboración meramente reactiva, centrada en propiciar que cada país pueda anteponer en toda cuestión su estricto interés nacional.
Between center-periphery and left-right: A comparison of traditional and new regionalist parties’ strategies in Galicia during the Great Recession
Authors: Gómez-Reino Margarita , Marcos-Marne Hugo
Published: June 2022

This article explains the rise, success, and subsequent failure of new challenger formations in the Galician party system during the Great Recession. For that, it focuses on the multidimensional electoral strategies developed by Alternativa Galega de Esquerda (AGE) and En Marea, comparing them to that of the traditional Bloque Nacionalista Galego (BNG). Our analysis shows the different strategies displayed by the BNG and new challengers (AGE, and later En Marea), examining both the electoral supply (framing and party programmatic positions) and demand (voter positions). We find a new subsuming strategy developed by AGE and En Marea, which prioritized left-wing anti-austerity policies over core pro-periphery ones. The paper demonstrates the potential of this new strategy during the Great Recession but also its limitations, linking its demise to the organizational weakness that prevented electoral realignment, and ultimately allowed the BNG to regain its leading role in the territorial dimension of competition.
Fragmentación y polarización parlamentarias en las Cortes Generales españolas (2015-2019)
Authors: Nieto-Jiménez José C.
Published: June 2022

En este artículo nos aproximamos a dos conceptos que en los últimos años han marcado el devenir de las legislaturas de las Cortes Generales, la fragmentación y la polarización parlamentarias. En el contexto de quiebra del bipartidismo imperfecto vigente en España desde los albores de la Transición, el objetivo principal del texto pasa por corroborar la irrupción del parlamentarismo fragmentado y polarizado en las Cortes Generales españolas a partir de las elecciones generales de diciembre de 2015. A tal fin, proponemos un concepto de fragmentación parlamentaria basado en la relación de esta y los grupos parlamentarios, revisamos los temores y presunciones que presidieron el diseño constitucional durante la Transición y, en último término, aplicamos los indicadores previamente concretados tratando de identificar las legislaturas en las que están presentes simultáneamente las notas de la fragmentación y de la polarización parlamentaria. Esto último posibilitará concluir si el escenario de fragmentación e inestabilidad supuesto para el sistema parlamentario de los años posteriores a la entrada en vigor de la Constitución de 1978 se ha correspondido o no con la realidad.
Instituciones islámicas en Bosnia-Herzegovina y España. Diferentes formas de politizar la religión
Authors: Martín Lupiañez Isaac
Published: June 2022

El presente trabajo describe la actualidad institucional islámica de dos países diferentes en el panorama europeo. La trayectoria histórica e identitaria es crucial en el caso de Bosnia-Herzegovina, mientras que en el caso de España, la gestión del islam fue tratada desde el control estatal hacia una minoría religiosa. Sin embargo, ambas instituciones islámicas comparten la jerarquía y el orden en sus proyectos, a pesar de la lentitud y relativa novedad del caso español. Estas diversas realidades han producido dos modelos que conforman reseñables ejemplos de la variada gestión del islam europeo y su relación con los Estados modernos.
A comparative study on efficacy of oral terbinafine and itraconazole on dermatophytic infections
Authors: Kumar Govind , Saxena Kshitij , Koti V. Rao
Published: June 2022

Background: The increased cases of dermatophyte infections and their poor response to oral drugs with current doses and duration of treatment is common. So, we conducted the study with a goal to assess the efficacies of two antifungal drugs with their increased dosages and duration. 

Methods: A prospective comparative study was done on 145 patients belonging to age group 18-60 years which were both clinically and microbiologically confirmed cases of tinea cruris and tinea corporis. Patients were randomized into two groups A and B. Group A patients were given capsule itraconazole 100 mg twice daily and group B were given tablet terbinafine 250 mg twice daily, both for 6 weeks. Patients were followed up at 2, 4 and 6 week and at each visit, scores for 3 parameters (erythema, scaling and pruritus) were recorded and were analysed.

Results: A total 140 patients completed the study with 72 patients in group A and 73 patients in group B. In group A 72.5% patients achieved complete remission compared to 67.6% in group B. At each follow up patients were evaluated based on total symptom score (erythema, scaling and pruritus) which had shown significant improvement with negative potassium hydroxide results. None of the patients had severe side effects.

Conclusions: Study showed that Itraconazole has higher clinical and mycological cure rates as compared to terbinafine. So itraconazole is superior to terbinafine in treatment of tinea corporis and cruris.
Gestión del talento humano y control de la corrupción: el efecto del Programa de Nuevos Talentos en Control Gubernamental sobre la detección de corrupción en Perú
Authors: Pierri Gastón , Lafuente Mariano
Published: June 2022

Las iniciativas de control gubernamental han demostrado cierta efectividad en la lucha contra la corrupción, sin embargo, existen espacios de aprendizaje en la literatura en cuanto a cómo las mejoras en las capacidades y conocimientos de los auditores inciden en esa efectividad. En esta publicación se busca presentar evidencia acerca del impacto del programa de Nuevos Talentos en Control Gubernamental de la Contraloría General de la República (CGR) del Perú sobre la eficacia en el procesamiento de denuncias ciudadanas. Este programa brinda un riguroso proceso de formación y especialización a los profesionales reclutados desde fuera de la CGR y seleccionados por orden de mérito (con una tasa de aceptación del 1,25 %), por lo cual se espera que los funcionarios que atravesaron este proceso de selección y recibieron este entrenamiento tengan un mejor desempeño. A partir de datos del sistema de denuncias de la CGR y del entrenamiento especializado, se aplica la metodología de diferencia-en-diferencias para evaluar el impacto del programa a nivel de las oficinas regionales. Los resultados evidencian que las oficinas que incorporaron Nuevos Talentos en su equipo incrementaron en 36 puntos porcentuales la tasa de éxito de las denuncias, en 32 puntos porcentuales la tasa de éxito de los hechos denunciados y en 27 puntos porcentuales la tasa de éxito de las alarmas. De acuerdo a estos resultados preliminares, el programa parece representar una iniciativa efectiva para mejorar los procesos internos de la CGR y contribuir a la lucha contra la corrupción.
Processo coletivo sancionador anticorrupção
Authors: Augimeri de Goes Lima Thadeu
Published: June 2022

O artigo analisa o microssistema especializado existente no ordenamento jurídico brasileiro que pode ser denominado microssistema processual coletivo sancionador anticorrupção, composto pela Lei de Improbidade Administrativa (Lei 8.429/1992) e pela Lei Anticorrupção (Lei 12.846/2013) e dirigido à tutela do patrimônio público e da probidade administrativa, mediante a aplicação de sanções punitivas e ressarcitórias aos autores, partícipes ou beneficiários de condutas ilícitas tipificadas extrapenalmente e violadoras de ditos bens jurídicos. Situa o patrimônio público e a probidade administrativa no quadro dos interesses supraindividuais e trata dos principais aspectos da Lei de Improbidade Administrativa (LIA), após as modificações promovidas pela Lei 14.230/2021, e da Lei Anticorrupção (LAC), enfocando ainda como elas se coordenam sistematicamente. Ao final, traz as principais conclusões obtidas no estudo. A abordagem privilegia os métodos dialético, comparativo e sistemático.
From early childhood to the first year of school: Connecting practices for mathematics learning and teaching
Authors: Thomas Becs , Mackay Kirsten , Stephenson Niki , McChesney Jane
Published: June 2022

This article reports from a Teacher-led Innovation Fund project that investigated connecting practices and resources for mathematical learning between a kindergarten and the first year of school. Teachers at both sites were teacher-researchers in the 2-year project. Our results highlighted expected and unexpected aspects of connections and connecting practices. Language played a critical role, and even brief drops of language were used by teachers to identify opportunities for further mathematical learning. Another finding was that teachers became more attuned to mathematical possibilities and included more questions and provocations, resulting in extended mathematical conversations.
Anticancer effects of zapotin flavone in human gastric carcinoma cells are mediated via targeting m-TOR/PI3K/AKT signalling pathway
Authors: Chen Yunlan , Han Jiangqiong , Wang Guoqin , Qian Bin , Zhao Hua
Published: June 2022

The current study aims to investigate the anticancer effects of zapotin flavone in human gastric carcinoma cells. MTT assay was performed to determine the cytotoxicity effects of zapotin against the gastric cancer cells (SNU-1) and normal gastric cells (GES-1). SNU-1 cell morphology was analyzed through phase-contrast microscopy. Apoptosis was identified through DAPI staining assay and quantified through annexin V/propidium iodide (PI) staining. The effects on cell migration and invasion were carried out through transwell assay. Apoptosis and m-TOR/PI3K/AKT signalling pathway related proteins were analysed through western blotting. Proliferation rate of gastric cancer SNU-1 cell line declined with enhanced zapotin concentrations in comparison to normal GES-1 cells. Substantial morphological changes after zapotin exposure, including nuclear condensation and membrane rupture was observed. Further, increasing number of apoptotic cells, suppression of both cell migration and invasion was observed with increased zapotin concentrations. Finally, western blotting indicated significant blocking of m-TOR/PI3K/AKT signalling pathway. We conclude that zapotin can act as a potential drug against the gastric cancer.
ENTRE A EUROPA E A AMAZÓNIA - DO RITUAL DA ARTE DO PODER AO PODER DA ARTE DO RITUALENTRE A EUROPA E A AMAZÓNIA DO RITUAL DA ARTE DO PODER AO PODER DA ARTE DO RITUAL
Authors: Mourão Rui
Published: June 2022

Rui MourãoFCSH-UNL
5th International Conference EnRe-Energy&Responsibility: Book of Extended Abstracts
Authors: Seme Sebastijan , Avsec Jurij , Sredenšek Klemen
Published: June 2022

The tendency to improve energy devices, the impact of environmental factors and the development of new technologies for the exploitation of sustainable resources contribute to the fact that we have witnessed intensive energy development in the last decade. The two most important Slovenian energy pools, located in Velenje and Krško, are at the turning point of renovation, and are facing major challenges in the design and planning of modern energy devices. The current generation faces a great ethical responsibility to leave their descendants a world with as little human impact on the environment as possible. Therefore, communication between experts and researchers, discussion and exchange of different views for the future is of the utmost importance, which is exactly the purpose of the EnRe Conference.
Varietal Susceptibility and Disease Resistance of Tomato Cultivars against Meloidogyne incognita in Greenhouse Condition
Authors: Ikram Mohd , Khan Arshad , Fatima Saba , Ansari Taruba , Siddiqui Mansoor A. , Tariq Moh
Published: June 2022

Background: Root-knot nematodes (Meloidogyne spp.) are the most devastating pests of vegetables, especially in the tropic and subtropic regions. Meloidogyne incognita is among the major pathogens found in the tomato crop and causes a significant yield loss. This study evaluates the resistance and susceptible cultivar of tomato against root-knot nematodes (Meloidogyne incognita). Methods: A greenhouse study was conducted to evaluate the resistance or susceptibility of nine tomato cultivars against M. incognita. Nine cultivars of tomato (Jyoti-4, Navuday, P-21, T9, Pusa-Rohini, Pusa-Sheetal, Pusa-Ruby, Tomato-Ped and Tomato-Round) were procured from Indian Institute of Agriculture Research (IARI), New Delhi and Chola seeds store Aligarh, Uttar Pradesh, India. Two weeks old seedlings of each cultivar were transplanted singly into each pot of 15 cm diameter (1 kg mixture of soil). Only one healthy seedling of each cultivar was maintained in each pot, including the control. Each pot was inoculated with 1500 freshly hatched second-stage juveniles (J2s) of M. incognita. This experiment was carried out in a completely randomized design (CRD) with five replications of each cultivar. Result: According to the rating scale of galls and reductions in growth parameters, cultivars Pusa-Ruby and Tomato-Ped were found highly susceptible. Five cultivars, namely Jyoti-4, Navuday, Pusa-Sheetal, P-21 and Tomato-Round were found susceptible, while cultivar Pusa-Rohini was found moderately susceptible. Only one cultivar viz., T9, was found moderately resistant.
Optimization of Agrobacterium tumefaciens-mediated Transformation in Oxalis corniculata (L.)
Authors: Rajagopal M. , Reddy C.M. Narendra , Prasuna V.N. Swetha , Lakshmi P.V. Chaithanya , Srinivas B.
Published: June 2022

Background: Optimization of co-cultivation parameters during Agrobacterium-mediated transformation to Oxalis corniculata evaluated were bacterial density, infection period, acetosyringone (AS) concentration and co-cultivation temperature. Five fold transformation efficiency is achieved in transient gus gene expression after optimizing various parameters. The optimized conditions were Agrobacterium tumefaciens growth phase of A600nm 0.17, infection period of 30 min, addition of acetosyringone (AS) in co-cultivation medium (400 μM) and cocultivation temperature of 22°C. Methods: Oxalis corniculata (L.) were used for transformation. Bacterial culture was added to 50 ml of liquid YEP medium with kanamycin and rifampicin and grown until reaching the growth phase (A600nm). Bacterial density ranged from A600nm 0.17, 0.56,0.80 and 1.34 OD were used in the present study. The co-cultivation medium made of solid MS medium consisted of BAP 2 mg L-1 and NAA 0.5 mg L-1 and various concentrations of AS at 0, 50, 100, 200, 400,600 and 800 μM. Histochemical analysis of gene expression was carried out. Result: Higher bacterial density resulted in more transformation efficiency, but also higher necrosis in the explants. Dilution of bacterial suspension reduced necrosis in explants and resulted in higher transformation. The transformation efficiency is 64% when the infection process was carried out with acetosyringone in co-cultivation medium (400 μM). Our studies proved that among the optimized conditions, cocultivation temperature and acetosyringone were the critical parameters during Agrobacterium mediated transformation.
Neuroprotective Effect of Phaseoloidin in Scopolamine Induced Amnesia, Neuro-inflammation and Apoptosis in Mice
Authors: Barua Chandana Choudhury , Buragohain Lipika , Goswami Abhinab , Pathak Debesh Chandra , Phukan Arabinda , Barua Acheenta Gohain
Published: June 2022

Background: Alzheimer’s disease (AD) is a major form of dementia among neurodegenerative diseases, which results in memory deficits. There is no report of the memory enhancing activity of Entada phaseoloides, however we reported its potential as a memory enhancing compound and based on this study, its isolated compound Phaseoloidin is taken up for the present study in scopolamine induced memory impairment in Morris water Maze (MWM). Methods: Mice (n=6/group) treated with Phaseoloidin (100 and 200 mg/kg) and the standard drug Tacrine (3 mg/kg, i.p.) were pretreated with scopolamine. Animals were sacrificed to evaluate AChE and lipid peroxidase, nitric oxide, reduced glutathione, superoxide dismutase, catalase. Gene (BDNF, TrkB, NF-êB p65, Caspase-3) expression studies by Western Blotting and AChE, PP2A, Tau, Nrf2 and HO-1 by Reverse Transcriptase PCR and Real Time PCR. Result: Phaseoloidin and Tacrine significantly improved memory dysfunction by decreasing escape latency during training and enhance in time spent in target quadrant. Its treatment reversed the scopolamine induced elevation of AChE, elevated SOD, GSH, Catalase levels and decreased LPO, NO levels in the hippocampus. Expressions of BDNF, TrkB, NF-êB p65 and Caspase-3 were up regulated in the treated group. It suppressed mRNA expression of AChE, Tau and increased Nrf2, HO-1, PP2A. Thus, Phaseoloidin could be a potent neuro-pharmacological compound against amnesia.
Reliability and Validity Testing of the Caregiver-Centered Communication Questionnaire
Authors: Demiris George , Pitzer Kyle , Washington Karla , Oliver Debra Parker
Published: June 2022

Objective:The purpose of this study is to test the reliability and construct validity of a new instrument, the Caregiver-Centered Communication Questionnaire (CCCQ), designed to assess the extent to which family caregivers feel their perspectives and needs are appropriately acknowledged and addressed by the healthcare team.Methods:We administered the CCCQ to adult family caregivers of hospice patients. We calculated Cronbach’s alpha and performed structural equation modeling. Following the estimation of the congeneric model, modification indices (MI) were examined to establish cross-loading. We used RMSEA, CFI and TLI, and SRMR to determine the quality of model fit.Results:A total of 525 caregivers completed the CCCQ instrument. The Cronbach’s alpha was α = 0.98, indicating good reliability. Our final model demonstrated good fit to our data, χ2(354) = 711.653, RMSEA = 0.044(0.039, 0.049), CFI = 0.99, TLI = 0.99, SRMR = 0.029.Conclusion:Caregivers are asked to play an ever-increasing role in managing aspects of care. This role is not fully reflected in available toolkits to assess processes of care, and the CCCQ, designed to address this gap, was found to be reliable and valid. Assessing caregiver centered communication should and can be integrated into the evaluation of health care services delivered to patients and families.
A Preliminary Exploration of the Influence of Intimate Partner Violence Victimization on Perceptions of Others’ Intimate Partner Violence Experiences
Authors: Kirby Charli M. , Jarnecke Amber M. , Leone Ruschelle M. , Flanagan Julianne C. , Johnson Ralph H.
Published: June 2022

Purpose

Psychological intimate partner violence (IPV) will impact almost half of US adults throughout the lifespan and as many as 80% of undergraduate college students; however, psychological IPV remains understudied. Examining perceptions of IPV can aid in the identification of potential barriers to treatment seeking and advance intervention efforts. The current study intended to determine how myths and stigmatizing beliefs about IPV affected the minimization (i.e., neutralization) of IPV acts and how history of psychological IPV victimization could moderate the aforementioned associations.

Methods

Participants were undergraduate students in the southeastern United States (N = 52) who were currently, or had previously been, in a relationship for at least 1 month. Data were collected regarding IPV victimization and perpetration and perceptions of IPV, including stigmatizing beliefs, myth endorsement, and neutralizing beliefs.

Results

Findings indicated that those reporting higher levels of psychological IPV victimization endorsed more neutralizing beliefs about IPV more stigmatizing beliefs about females experiencing IPV victimization, compared to those reporting fewer stigmatizing beliefs towards females experiencing IPV. That is, individuals who have experienced psychological IPV and also stigmatize females experiencing IPV victimization may tend to normalize IPV.

Conclusions

Findings illuminate how perceptions and personal experiences of IPV can minimize someone’s views of the severity of others’ IPV victimization. This research has implications for highlighting barriers to help-seeking behaviors for individuals experiencing IPV and informing future studies about help-seeking in undergraduate populations.
Extremely rare coronary artery anomaly: Left main coronary artery originating from the non-coronary sinus
Authors: PINARCI Cihat , BAYRAKTAROĞLU Selen
Published: June 2022

Although they are rare, left coronary artery anomalies can cause complications with high mortality, including arrhythmia and cardiac arrest. Left main coronary artery originates from the non-coronary sinus abnormality is rarely observed. This abnormality has been defined as a benign pathology in the past, although it is described in the literature to cause morbidity and mortality in some cases. We present very rare case of the left main coronary artery arising from non-coronary sinus detected on CCTA.
Les actualités cinematographiques en France
Authors: Bittar Xavier
Published: June 2022

El artículo tiene por objeto las noticias filmadas - principalmente francesas - del período 1930-1936. Algunas noticias se inscriben en un marco político con la llegada de Hitler al poder en 1933. Tres años después, en el momento del Frente Popular, se muestra una Francia en huelga, una huelga que incluso tendrá un impacto en la actividad cinematográfica.

Se menciona más concretamente la forma en que las noticias dan cuenta del asesinato del rey de Yugoslavia el 9 de octubre de 1934 y del comienzo de la guerra de España en 1936. A través de informes en la prensa y privilegiando los testimonios de los operadores de la época, se vuelve en particular sobre el comienzo de su mediatización así como sobre la ambigüedad de su posicionamiento ante ciertos hechos políticos.  Si reivindican cierta neutralidad, su implicación les da paradójicamente una pretensión periodística.
Flipped classroom and the use of role-play in the COVID-19 pandemic
Authors: Chisini Luiz Alexandre , Conde Marcus Cristian Muniz , Alves Alessandro Menna , Costa Francine dos Santos
Published: June 2022

Aim: In Brazil, COVID-19 remains one of the epicenters of the pandemic, thus, presential educational activities are suspended. The study aimed to describe the approach of flipped classroom performed to provide social distancing and to maintain teaching activities during COVID-19-pandemic. Methods: Flipped Classroom was chosen to be associated with the role-play technique as a central methodology. To bring students closer to activities performed in the non-pandemic period, some actions and assessments were also role-played by Professor simulating patients in virtual meetings. Results: Although the changes in the format of the lessons, our approaches stimulated the students maintained the high frequency of students in the activities (almost 100%) providing continuity activities. Conclusions: This report can reinforce that meaningful learning can be taught by using a virtual/remote approach. However, the potential positive results observed cannot be used as an excuse to maintain remote teaching activities with the objective of cost-cutting by the institutions.
Escrita acadêmica no campo da educação
Authors: Brasileiro Ada Magaly Matias , Oliveira Adilson Ribeiro de , Souza Kariny Cristina , Pimenta Viviane Raposo
Published: June 2022

Em tempos de acirrada política neoliberal comprometida com o produtivismo acelerado, o artigo é uma das formas de comunicação que mais circulam no âmbito acadêmico-científico, objeto sobre o qual recaem muitos dos índices de ranqueamento institucionais e é ele próprio tema recorrente de estudos vinculados aos estudos do letramento, à didática da escrita e aos estudos do discurso. Encontramos em Swales (1990) propostas que buscam articular saberes de campos teóricos distintos que podem contribuir para a didática da escrita acadêmica. Nessa seara, o objetivo principal deste estudo é compreender como a orientação retórica de introduções e conclusões dos artigos científicos da área da Educação se faz presente na composicionalidade, no estilo e no desenvolvimento temático desse gênero. Trata-se de uma pesquisa documental, cujo corpus é composto por 16 artigos da área da Educação, tendo sido os periódicos avaliados como Qualis A1, no quadriênio Capes 2013-2016. Os resultados revelam a presença dos movimentos retóricos apontados por Swales, por meio das estratégias discursivas de engajamento e posicionamento (HYLAND, 2015), e contribuem para a composicionalidade do gênero. Apesar disso, não é possível afirmar, como descrito por Swales, que tais movimentos sejam de ordem obrigatória. Verificou-se também que as configurações de escolhas sistemáticas de linguagem devem ser compreendidas no interior de um campo disciplinar e que o texto reflete as escolhas e as limitações que atuam sobre os autores.
Phototype
Authors: Venson Ramon , Callaghan Michael , Marcelino Roderval
Published: June 2022

Os resultados positivos demonstrados por diversas pesquisas sobre o uso de novas tecnologias da informação na educação evidenciam novas formas de atrair e engajar estudantes no processo educativo. Uma dessas tecnologias, chamada de Jogos Sérios, propõe a utilização de jogos digitais com finalidades para além do entretenimento do jogador, como educação, marketing e política. Esta pesquisa descreve o desenvolvimento de um jogo sério voltado ao processo de ensino-aprendizagem de normas, procedimentos e termos técnicos sobre sistemas fotovoltaicos. O jogo Phototype foi desenvolvido sob o apoio de metodologias voltadas a jogos educacionais, como o Heuristic Framework e o Learning Mechanics – Game Mechanics; e avaliado por intermédio de um questionário e instrumentos técnicos que observaram a percepção dos estudantes de um curso superior em relação às mecânicas de jogo e aprendizado do jogo digital. Os resultados da pesquisa identificaram uma experiência positiva por parte dos estudantes na utilização do jogo Phototype, sugerindo sua importância como ferramenta educacional e de apoio ao ensino-aprendizagem, complementando o resultado de pesquisas anteriores.
A disputa de Nietzsche com Sócrates e seus efeitos para a educação
Authors: Hardt Lúcia Schneider
Published: June 2022

O artigo debruça-se sobre a filosofia dos antagonismos de Nietzsche para buscar suas repercussões formativas considerando a arte, ciência e a educação. O modelo agonístico presente na obra de Nietzsche é tomado como definidor para as apreciações das sutilezas dos embates filosóficos, especialmente a disputa com Sócrates. Na dinâmica da disputa, a potência do elogio, da crítica e também de uma autocrítica. Este solo filosófico conecta-se com o solo pedagógico, fazendo surgir métodos de análise e de prática que configuram uma possível educação agônica. Nestes termos, a disputa educativa resgata uma vitalidade por meio do método genealógico que visa discutir invenção, descoberta, explicação e interpretação considerando o arranjo dos conceitos para contestar sua imutabilidade ontológica e gerar nova orientação em termos epistemológicos. Mostrar disposição em pensar com Nietzsche, sem necessariamente abandonar Sócrates, implicaria refletir sobre como o excesso de fixidez instaurada por nossas invenções pedagógicas têm impedido descobertas mais robustas para fazer acontecer outra educação.  Será necessário antes questionar o valor da verdade que ainda reina entre nós para levar às últimas consequências o projeto nietzschiano de transvaloração de todos os valores.