bluuebunny/crossref_metadata_2025 huggingface dataset:
The Internal Picture of the Child’s Health Viewed in the Context of Parent-Child Relationship
Authors: Merenkovawati V
Published: May 2020

The main function of the internal picture of health (IPH) is the regulation of a person’s activity or behavior, and is aimed at maintaining the person’s health, illness prevention and illness resistance. There is one subject that continues to be insufficiently accessible to psychological research, i.e. the system of the parenting style adopted in a family and the IPH levels of their children. We can suppose that IPH is one of the major indicators of the health-oriented behavior, the latter being significantly influenced by the interfamily relationships and the parenting style.
Methods: there were 82 primary school children who participated in the study. Along with the children, their mothers also took part in the research. Practically all of the fathers agreed to enroll in the study, but in fact only a few were actually involved, which was not enough to provide evidence-based conclusions. The IPH of the children and their parents was evaluated by means of a questionnaire (Nikolaeva et al., 2014). Upbringing styles were assessed by “The Analysis of Family Relationships” questionnaire (AFR method). We have shown that the better-developed the IPH is, the more likely it can signify a harmonious upbringing style. A low level of the parents’ emotional intelligence results n the predominance of indulging hyper protection parenting style which is considered ineffective.
Keywords: the internal picture of health, parent-child relationship, parents, primary schoolchildren.
Actualization of Potential Life Experience in Normal Aging
Authors: Naumova V , Glozman J
Published: May 2020

The paper search mechanisms for maintaining personality well-being at the stage of late ontogenesis, which is important for neuropsychology, gerontology and psychology. The authors analyze the preserved cognitive resource, acquired at the previous age stages, as a resource for life experience mobilization and providing adefinite level of intellectual and mental indicators in normal aging. The experience proves that preserved self-regulating abilities in elderly are the main condition of actualizing life experience potential. Specially organized environment in thematic art-groups providing the process of goal-oriented activity and adequate interpersonalinteraction is viewed as a determining factor of life experience implementation. The dynamics of viability components reflecting sustainable strategies of self-regulation is investigated and the results of this investigation are presented.
Keywords: potential life experience, normal aging, viability, cognitive resource.
Handedness: Manual Lateral Parameter – or the Result of the Researcher’s Manipulation
Authors: Nikolaeva E , Vergunov E
Published: May 2020

The purpose of the research was to compare different methods of handedness assessment. Participants included 161 children between 4 and 7 years of age: 87 girls and 74 boys. The research incorporated typical methods used in investigations and assessment of lateral phenotype. All tests were repeated at least three times to assess their reliability in assessing children. Our findings reveal that different sets of assessments and scoring methods produced different results in determination of right- or left-handedness. Factor analysis identified three significant factors of handedness: social pressure, genetic mechanisms, and two-hand coordination. We conclude that it is necessary for assessment of handedness to use at least three testsassociated with each of these factors.
Keywords: handedness, left-handedness, methods, lateral profile, children.
Effects of Neuropsychological Intervention in a Child with Functional Deficit in Programming and Control
Authors: Fernanda Ochoa Cardona M , Quintanar Rojas L
Published: May 2020

Introduction. The brain’s third functional block is considered an important element in the impairment of child development, which has been conceptually linked to ADHD and learning difficulties. Its rehabilitation presents some skepticism regarding the effectiveness of the treatments. This is associated with the lack of relationshipbetween the established diagnosis and the intervention proposal, the lack of knowledge of the basic psychological needs of each age and the design of an intervention program that corresponds to the neuropsychological syndrome.
Methodology. The main purpose of this paper is to present the results of a neuropsychological intervention in a 11-year-old schoolgirl from the city of Puebla-México with a functional deficit in programming and control mechanism. The intervention program was scheduled twice a week for 11 months; gauging its effectiveness with pre-post neuropsychological and electroencephalography (EEG) assessment. The EEG data revealed functional bilateral changes of origin in basal ganglia, mesencephalic and of the brainstem. The method of qualitative syndromic analysis of the functional status of the cerebral mechanisms was used, especially in mistakes made at different tasks associated with the mechanism involved. The program was elaborated based on the structure and content of the school learning activity and zone of proximal development.
Results. A significant improvement was observed in the functional state of programming and control and improvement in school performance.
Conclusion. Approaches to child correction like the cultural-historical are necessary in the neuropsychological field to generate methods that guarantee the psychological and neuropsychological development.
Keywords: Neuropsychological syndrome, child neuropsychology, child neuropsychological intervention, developmental problems, subcortical structures.
Investigation of Vandal Behavior of the Social Situation in the Territory in the Period of Destruction
Authors: Obolenskaya A
Published: May 2020

The article describes modern types and risks of vandalism in cities environment. Vandal activity in cities is steadily increasing (Mursalieva, 2017). New types of vandalism appear in streets of megalopolises, where involvement in crime communications tends to 70%. Surveyed townspeople often do not see anything reprehensible in perfect vandalism, like graffiti and product logos, to use municipal and private property for their messages. Graffiti on a municipal building, trampled lawns, broken garbage bin on the street is not considered something unusual, it’s public goods and it seems to be a draw. Perception of spoiling becomes a habitual norm. However, the alternative consequences for the citizens-spectators and the actors themselvesconstitute serious risks for socialization, mental and physical health, a sense of well-being. Vandalism is also active as a marketing communication, in which ads are placed in the city’s space without the consent of the owner of the building, which causes anxiety of the owner and users of the premises and the territory as a whole. We analysed more than 3 thousand objects damaged by vandals in the megacity of Yekaterinburg, which is located in the center of Russia and includes 7 districts. 1.5 million residents live in elite housing and old low-budget homes. Even well-protected residential complexes have graffiti. However, in low-density areas there is more graffiti as a criminal communication.
Keywords: vandalism, destruction of the social situation, territory, economic of vandalism, economic behavior.
Functional Organization of the Brain and Psychic Activity: A View Beyond Luria (With Luria)
Authors: Pena-Casanova J
Published: May 2020

This paper reviews, elaborates, and rebuilds Luria’s model of the three functional units of the brain. As a result, five functional brain units have been delineated: preferential (unit for life-support and arousal regulation), limbic (unit for valuation/motivation and for context memory), cortical and thalamic-cortical (“the conscious agent”), basal ganglia (”the reinforcer”), and cerebellar (”the supervisor”). The new model is more realistic; it includes elements missing from Luria’s model and avoids a corticocentric approach. It will allow a better analysis of the effects of brain pathology on cognition, neuropsychiatry, and behavior. Within the framework, the concept of complex functional system is maintained and expanded.
Keywords: brain, functional model, complex systems, cortex, Luria
School Adjustment Problems of Fifth Graders As a Risk Factor in Learning Difficulties
Authors: Permiakova M
Published: May 2020

In recent years, there has been a tendency in Russia to separate primary school from secondary one; gymnasiums and lyceums where children are recruited in the fifth grade through a competitive examination start operating. Despite the fact that such schools enroll children from prosperous families who perform well at school, some of them start experiencing learning difficulties resulting in dramatic decrease in academicperformance, behavioral problems, and health deterioration. One of the risk factors for these problems is the difficulties of adjusting to a new school, conditioned by agespecific psychological and physiological conditions of fifth graders and pedagogical factors. The purpose of this study is to increase awareness of fifth graders school adaptation, collect empirical data, by examining the relationship between its variouscomponents, as well as self-esteem. The present study explored 144 fifth graders aged 10-11 (74 boys and 70 girls) and their 6 class tutors (homeroom teachers). Measures: School Anxiety Questionnaire (B.N. Phillips), expert evaluation, «Sociometry» ( J.L. Moreno), self-esteem methodology called «Ladders». The results of the study into academic, social and psychological aspects of fifth graders School adjustment showed that the period of adaptation is characterized by decreased academic performance compared to the fourth grade while a third of the subjects lacked interest in studying. 39 % of fifth graders showed a low sociometric status.More than half of the students (55 %) are dissatisfied with their relationships with their classmates. An increased level of school anxiety is typical for 25% of fifth-graders. The main causes of school anxiety are fear of self-expression, problems with the teacher, fear of not meeting the expectations of others. Factor analysis proved a three-fold structure of school adaptation. The correlation analysis showed that academic adaptation is related to all components of school adaptation, whereas social and psychological components are not linked.55 % of fifth-graders have low or poor self-esteem. They are most dissatisfied with their lack of authority among their classmates and their appearance. Factor analysis demonstrated that the self-esteem of fifth graders in the period of adaptation to secondary school is more connected to the indicators of the social component ofadaptation. Teachers adequately evaluate only student performance and behavior, but not their sociometric status, school anxiety, and interest in learning. This complicates the identification of the problem and timely assistance to the fifth graders with difficulties in social and psychological adaptation.
Keywords: school adaptation, learning difficulty, fifth-graders, self-esteem, school anxiety, sociometry
Mindfulness As a Meta-Predictor of Personal and Professional Competence of a Labor Subject
Authors: Semenov D
Published: May 2020

Background: The article deals with psychological factors affecting professional development of a labor subject under the conditions of socio-economic shocks, information overloads and modernization of virtually all areas of professional activities. The research looks at psychological predictors of an individual’s constructiveprofessional development, as well as conditions for building coping skills in such critical situations as stress, conflict, frustration, etc., which are the causes of emotional burnout, professional destruction, deviant behavior, deterioration of occupational and psychological health, psychosomatic disorders, and so on. The analyzed phenomenon is a labor subject’s ”psychological immunity” to professional destruction stemmingfrom multiple increase in intensity of negative impact on individual psycho-emotional state. The research defines the role of psychological immunity in constructive professional development and personal and professional competence. Design: Academic novelty of the article consists in analysis of the psychological construct of mindfulness, which is new to Russian science. The author views this construct as a psychological meta-predictor of personal and professional competence belonging to the structure of personal and cognitive features of individuals and ensuring effective unleashing of their personal potential. Results: The research has found out the link between the psychological predictors of constructive professional development and the mindfulness level of an individual, which makes it possible to broaden the understanding of individual psychological characteristics and capabilities of labor subjects in their topmost achievements, to define strategies for effective use of psychological and intellectual resources of a professional, for choice betweendestructive and constructive professional development in favor of the latter and for shaping personal and professional competence. Conclusions: On the meta-cognitive level mindfulness contributes to building a labor subject’s psychological immunity for overcoming professional destruction, determines acquisition of personal and professional competences required for constructive professional development and an increase of personal and professional competence.
Keywords: Mindfulness, psychological predictors, meta-concept, personal and professional competence.
Psychomotor Development of Preschool Children By Means of Musical Improvisation
Authors: Shutova N , Suvorova O
Published: May 2020

This article is a fragment of a research project devoted to the study of the impact of the systematical musical influence on the integrated mental development of children. In this paper, we present an unique approach to the use of a criteria-oriented system for assessing the levels of psychomotor development of preschool children. Three estimated levels (from high to low) of child’s psychomotor development have been singled out. The range of characteristics of each level reflects the varying formation degree of the main indicators of the child’s psychomotor development and allows to establish both actual features of this development and to predict potential opportunities. The analysis of the results of the ascertaining experiment revealed some motor failures in a significant number of children aged 6-7 years. The failures manifested themselves in: difficulties of performing movements in accordance with instructions; violation of motor coordination, motor memory, inability to perform movements in accordance with spatial, temporal and dynamic characteristics, in thedistortion of tempo, rhythm and amplitude of movements (32.15%). The development program ”Music of My Body” presented in the article is aimed at overcoming the psychomotor underdevelopment of children and bringing them to the level of optimally realized age opportunities by means of musical improvisation plastics.As a result of the program, the following tasks are solved: developing a sense of rhythm and motor skills, the formation of correct posture and expressiveness of the movements, and facial expressions of children. The results of the program revealed positive changes in the psychomotor development of children. As a result of the program, the number of preschool children who demonstrated the first level in the development of motor skills almost doubled (from 13.82% to 38.09% at the control stage). The number of children with a low level of psychomotor development decreased (from 32.15% to 13.09% at the control stage). The dynamics of development based on the results of the control phase was statistically significant at a high level of reliability (p <0.001).
Keywords: psychomotor development, emotional and physical comprehension of music, ”sounding gestures”, improvisation, mimic intonation of music.
Patterns of Bioelectrical Brain Activity of Stroke Patients after Using Neurofeedback in the Rehabilitation Process
Authors: Trofimova A , Silina E , Dobrushina O , Isaychev S
Published: May 2020

Background: Stroke patients develop the ability to perform higher levels of functional activity on basis of concentrated rehabilitative training which affects sensory, motor and cognitive functions. Objective: The main aim of our work was to show the usefullness of neurofeedback therapy in rehabilitation of stroke patients. Design: 27 stroke patients with severe disabilitis were included in the pilot study (men aged 32 to 68 years, mean age 52.4 ± 3.29 years, median 57 years). They all underwent complex study of brain bioelectrical activity EEG and 15 trainings of neurofeedback. Results: By the end of the rehabilitation (after 17 sessions) recollection of psychotrauma led to an increase in the power of the alpha rhythm in both left and right hemispheres. Atthe endpoint of the study differences in the power of the alpha rhythm in the left hemisphere were 1.47 times greater, and in the right hemisphere, 1.95 times greater than at the first visit. The regress of theta rhythm (1.25 times in the left, 1.11 times in the right hemisphere) decreased considerable, which affected the alpha / thetaratio - decreased 1.04 times in the left, 1.18 times in the right hemisphere, and also the coefficient (alpha + theta) / beta - decreased 1.17 times in the left and 1.21 times in the right. Differences in the saturation of blood vessels index at the last visit were 1.69 times greater than at the first visit. Neurophysiological changes correlated with an improvement in the emotional shpere. By the time of discharge, the indicators on the Beck depression scale decreased by 1.4 times, on the Spielberger-Khanin scale, situational anxiety decreased by 1.63 times, personal anxiety - by 1.4 times; regression of indicators in the hospital scale of anxiety and depression (HADS) was observed in 1.89 times. Conclusion: The data presented indicate that the use of the neurofeedbackmethod leads to a reduction of anxiety-depressive disorders, which positively affects the usefulness of combine rehabilitation.
Keywords: stroke, neurofeedback, electroencephalogram, alpha rhythm, rehabilitation.
Cognitive Function Estimation in Children with Tuberous Sclerosis
Authors: Troitskaya L , Malahova N
Published: May 2020

Tuberous sclerosis (TSC) is a genetic disease characterized by cerebral structural abnormalities (such as cortical tubers, subependymal nodes and abnormal cerebral white matter) which are detected by means of neuroimaging methods (e.g., MRI). Typically, these events cause neurological complications (i.e., epilepsy).Objective: cognitive function estimation in TSC children considering severity and nature of clinical course of the disease. 15 children with tuberous sclerosis (i.e., experimental group) and 46 children with normal development (i.e., control group) aged 6-16 years old underwent neuropsychological examination. As a result, polymorphic disorders of higher mental functions were revealed in TSC children. Neuropsychological deficit (p<0.05) was detected. Namely, voluntary attention and memorization impairments were found in TSC children with normaldevelopment. Operational thinking disorders, immaturity of dynamic and kinesthetic movement basis, somatosensory gnosis, optical spatial or quasi-three-dimensional imaging, as well as insufficient oral/aural and semantical memorization were mentioned in TSC children with mental retardation. Regardless of mental development, TSC children demonstrate neurodynamic activity disorder (p<0.05) presented by slow task performance, increased exhaustibility and attention fluctuation. According to comparison between research findings and clinical course data, severity of cognitive disorders substantially depends on epilepsy onset age because early onset results in more severe developmental disorder (p<0.05). Since tuberous sclerosis is a dynamic disease with new potential symptoms arising over a lifetime, neuropsychological testing will provide timely mental status qualification and development of corrective actions to activate the cognitive activity of a child.
Keywords: tuberous sclerosis, children, higher mental function (HMF) developmental disorders.
Instrumentos de predicción
Authors: Barragán Espinosa Jairo Alberto
Published: May 2020

La OPS/OMS, teniendo en cuenta la meta de “Salud para todos en el año 2000”, ha planteado dentro de las estrategias fundamentales para lograrla la “Atención Primaria en Salud”.De acuerdo con la situación actual de salud de los países del tercer mundo, la atención primaria en salud entra a jugar un papel importante en la prestación de los servicios y con el fin de hacerlos relevantes, se consideran los conceptos de niveles de atención como escalones de complejidad para brindar una oferta de buena calidad a la población, de acuerdo con sus posibilidades de acceso o grado de postergación.Para identificar aquellos grupos postergados debe incorporarse el concepto de Riesgo, que permite abordar la problemática de salud de un grupo determinado con un criterio preventivo, toda vez que conociéndose el o los factores de riesgo que inciden sobre la presencia de un daño, en un grupo o individuo, ofrece la posibilidad de intervenir con el fin de reducir o atenuar esos factores mucho antes de presentarse el resultado no deseado.
Os Influenciadores Digitais e a Relação com a Tomada de Decisão de Compra de seus Seguidores
Authors: Schinaider Anelise Daniela , Barbosa Isabelle Noga
Published: May 2020

No cenário atual cada vez mais as pessoas estão mais online do que off-line. Assim, novas formas de trabalho e marketing estão sendo escolhidas para suprir a demanda e chegar ao público alvo. Um novo modo de marketing está em alta com o marketing digital que, juntamente com o marketing de conteúdo, são os digital influencers que vêm com força para ser o modo de marketing mais eficaz. Objetiva-se identificar se os digital influencers auxiliam na tomada de decisão dos seus seguidores no ramo da beleza. Foi utilizado o método survey, sendo a coleta de dados por meio de um questionário, contendo 17 perguntas fechadas. Obteve-se uma amostra de 208 respondentes, em outubro de 2018. Evidencia-se que a maior parte dos respondentes são do sexo feminino inserida nesse campo de seguidores dos digital influencers, jovens e 66,3% tem Ensino Médio completo, concluindo que essa é a geração milênio voltado ao mundo da tecnologia. Ainda, as estratégias de marketing dos digital influencers transmitem confiança aos seus seguidores, tonando-se essa relação lucrativa para as marcas/empresas e os digital influencers. Conclui-se que os digital influencers no ramo da beleza influenciam na tomada de decisão de compra em seus seguidores.
Pensar o Brasil: novos tempos para ciência, tecnologia e inovação
Authors: Goncalves do Amaral Marcelo , Fisher Bruno Brandão , Carvalho Rodrigo Da Silva , E Oliveira Virgílio Cézar Da Silva
Published: May 2020

No limiar do vigésimo ano do novo século e milênio, um grande conjunto de mudanças é sentida em nossa sociedade, tanto em nível nacional quanto em âmbito global. O aprofundamento da transformação digital, iniciada há quarenta anos, as crises políticas e econômicas dos estados-nações, refutam completamente a ideia do fim da historia e da hegemonia norte-americana, abrindo espaço para uma nova dualidade ocidente-oriente. Nesse contexto, pensar o papel do Brasil em sua inserção na política internacional e nas cadeias globais de valor é essencial. Entretanto, pouca discussão tem sido feita sobre tais temas para se definir uma estratégia nacional. Em paralelo, discussões importantes sobre a configuração e financiamento dos entes de C&T&I do país foram trazidas à tona sem o devido cuidado e vêm gerando uma série de desconfortos e pânicos sobre o futuro de nossas instituições. Ao mesmo tempo que os setores mais dinâmicos da economia aceleram sua integração internacional, outros vão ficando cada vez mais distantes, assim fatiando o país em camadas ou grupos sociais que vivem em condições altamente heterogêneas em termos de desenvolvimento socioeconômico. Tal situação representa um fenômeno difícil de ser compreendido e tolerado à luz do conceito de cidadania  - e de difícil reversão, ainda que políticas de equidade sejam empreendidas. Sem fazer juízo de valor, a RASI se posiciona como um instrumento de discussão, acadêmico e profissional, das temáticas relevantes para o avanço da administração, da inovação e da sociedade em sentido amplo.
KAMU HARCAMALARI VE SOSYOEKONOMİK GELİŞMİŞLİK DÜZEYLERİ BAKIMINDAN İLLERİN GRUPLANDIRILMASI: TÜRKİYE ÜZERİNE BİR UYGULAMA
Authors: ATILGAN YAŞA Ayşe , YÜZBAŞI KÜNÇ Gonca
Published: May 2020

Bu çalışmada, Türkiye’de sosyoekonomik gelişmişlik göstergeleri dikkate alındığında öne çıkan iller ile kamu hizmetlerinden yararlanan illerin olası benzerlik ve farklılıklarının tespiti amaçlanmıştır. Çalışma kapsamında 2018 yılına ait kamu harcamaları fonksiyonel açıdan ele alınmış ve ilgili değişkenlere ilk olarak çok değişkenli istatistikî yöntemlerden çok boyutlu ölçekleme analizi ve kümeleme analizi uygulanmıştır. Sonrasında illere ait sosyoekonomik değişkenler ele alınarak çok boyutlu ölçekleme analizi ve kümeleme analizi kullanılmıştır.  Çalışma, yapılan uygulamalar sonucu elde edilen benzerlik ve farklılıkların değerlendirilmesiyle devam etmiştir. Çalışma sonucunda, söz konusu illerin sosyoekonomik gruplanmalarıyla kamu harcamalarına ait gruplanmalarının birebir olmasa da paralele yakın sonuçlar verdiği görülmüştür. Ancak bazı illerin sosyoekonomik açıdan daha gelişmiş düzeyde iken kamu harcamaları açısından daha düşük seviyede olduğu görülmüştür. Bazı illerin ise sosyoekonomik açıdan diğer illere göre daha az gelişmişlik seviyesindeyken kamu harcamaları açısından daha yüksek seviyede olduğu tespit edilmiştir.
PHILLIPS MAKİNESİ: İKTİSAT ÖĞRETİMİNE KATKILARI ÜZERİNE BİR ARAŞTIRMA
Authors: TAYYAR Ahmet Emrah
Published: May 2020

Bu çalışmanın temel amacı Phillips makinesinin iktisat öğretimine olan katkılarını incelemektir. İncelemede analiz aracı olarak Edgar Dale’nin yaşantı konisi ile öğrenme piramidi kavramları kullanılmıştır. Buna göre iktisat derslerinin sözel ve grafiksel yolla anlatımı yaşantı konisi kapsamında öğrenimin karmaşık, soyut ve daha çok başkaların yardımıyla edinilen bilgi bütününden oluştuğunu göstermektedir. Bu yolla öğrenme piramidi açısından %20 oranında akılda kalıcılık sağlanmaktadır. İktisat öğretiminde Phillips makinesinin kullanılmasıyla soyut iktisadi ilişkilerin görsel yolla anlaşılması mümkün olmaktadır. Cihaz yardımıyla kontrollü deneylerin yapılabilmesi tüm duyu organlarını kapsayan, daha somut ve kendi kendine öğrenme yoluyla gerçekleşen öğrenme sürecini ifade etmektedir. Dolayısıyla Phillips makinesinin iktisat öğretiminde kullanılması yaşantı konisinin tabanında bulunan doğrudan doğruya edinilen yaşantılar ile model ve numunelerle elde edinilen tecrübeler sınıflandırmasında yer almaktadır. Bu durum öğrenme piramidi açısından katılımcı öğrenme sürecini göstermekte olup öğrenilen bilgilerin %75 oranında akılda kalıcılığı sağlanmaktadır. Sonuç olarak Phillips makinesine benzer cihazların ve simülasyonların geliştirilmesi iktisat öğretiminin somutlaştırılması bakımından faydalı olacaktır.
SİYASAL DÜZEN ÜZERİNE KAVRAMSAL BİR İNCELEME
Authors: ERKEN Baki
Published: May 2020

Siyasal düzen kavramı siyaset biliminin en temel kavramlarındandır. Siyasal düzen küresel teorilerde ve ülkelerin gelişmesi / modernleşmesi konusunda bilimsel önem kazanmıştır. Siyaset biliminin temel kavramları ve siyasal düşüncenin temel teorileri kullanarak siyasal düzen hakkında bir bilimsel inceleme yapmak mümkündür. Bu makalenin kapsamı siyasal düzen kavram ve teorisidir. Makalenin temel amacı; siyasal düzen kavramına bütüncül bir yaklaşımla açıklama getirilmesine katkı sunmaktır. Makalede yöntembilim olarak, literatür taraması ve doküman analizi kullanılmıştır. Bu kapsamda ulaşılan temel tez; siyasal düzenin modern, Batılı ve bir Amerikan kavramı olduğudur. Siyasal düzen kavramı, klasik ve modern siyasal düşünce içerisinde temellenmiş ve 20. yüzyıl Amerikan siyasal düşüncesi içerisinde gelişmiştir. Kavramı geliştiren düşünür veya bilim adamları Amerikan hegemonyası savunucularıdır. Aynı dönemde gelişen modernleşme ve gelişme teorilerinin kavramları siyasal düzen kavramına önemli katkılar sunmuştur.
The Stratigraphic Architecture of Small Incised Valleys Along an Active Margin: Examples from the Oceanside Littoral Cell of the Southern California Coast
Authors: King Baird L. , Simms Alexander R. , Simkins Lauren M.
Published: May 2020

Compared to their equivalents along passive margins, less is understood about the stratigraphic architecture of incised-valley fill along active margins. Using approximately 10 km of shallow-marine seismic data and five vibracores, we compare the coastal incised-valley fill of two small southern California mountainous streams within the slowly uplifting and semiarid Oceanside Littoral Cell to incised-valley fill models from other active and passive margins. Our seismic data images the upper 16 m of the valley fill and contains three seismic units. The top unit is composed of a discontinuous drape of high-amplitude discontinuous subparallel reflections between 0.2 to 2 m thick, assuming a seismic velocity of 1500 m/s. The second unit is a 5.5- to 8-m-thick unit of faint chaotic reflections discontinuously compartmentalized by higher-amplitude mounded reflections. The lowest unit recorded in the seismic data is composed of a series of faint horizontal continuous reflections. A prominent reflector at 10 m separates the middle chaotic seismic unit from the lowest seismic unit. The shallow vibracores sampled the upper two seismic units, revealing a moderately well-sorted fine to very fine sand overlain by two silty units. The upper silt unit is bioturbated while the lower silt unit is well-laminated with laminations of gypsum sand. We interpret the silty units to represent a well-flushed mudflat overlying an enclosed evaporative mudflat. The second of these two facies appears to be unique to southern California estuaries undergoing uplift as an equivalent facies is not found within the estuaries developed within subsiding basins of the southern California coast. The sandy unit is interpreted to represent sandy lagoon or sandflat deposits. No cores sampled the lowest seismic unit; however, based on previously published data from neighboring incised valleys, we interpret it to be an open-estuary/central basin deposit. The fill within these small incised valleys is similar to that found along passive margins. The architecture of the valley fill is not dominated by tectonics but by eustatic sea-level rise. It lacks the multiple progradational phases and large volumes of coarse clastics common to other incised-valley fills from active margins. We attribute this difference to the generally low rates of uplift along this portion of the coast.
Tectonic Evolution of the Palos Verdes Fault–Lasuen Knoll Segment, Offshore Southern California
Authors: Thompson Michael , Francis Robert D.
Published: May 2020

Seismic mapping indicates that Lasuen Knoll in the Inner Borderland, offshore southern California, is a pop-up structure associated with a restraining stepover of the Palos Verdes Fault. Dextral shear is apparently transferred southeast through a complex zone of faults that includes the Carlsbad Ridge and Coronado Bank faults. This model is supported by comparison with other pop-up structures in the Inner Borderland and analogs to published sandpack laboratory simulations.

The Palos Verdes Fault along Lasuen Knoll has existed at least since the late Miocene Epoch (5 to 8 Ma) and is contemporaneous with the segment of the Palos Verdes Fault on San Pedro Shelf and adjacent to the Palos Verdes Peninsula. Isochore maps of stratigraphic intervals indicate that extension occurred locally along the Palos Verdes Fault adjacent to the present Lasuen Knoll pop-up during the Mohnian Stage and became more widespread during the Delmontian Stage (approximately 7.5 to 5 Ma). Repettian strata onlapping Lasuen Knoll indicate that the knoll began to form as a pop-up structure by the early Repettian (entire stage approximately 5 to 2.3 Ma) and has been active possibly until the Holocene.

Transtensional zones occur along the Palos Verdes–Carlsbad Ridge–Coronado Bank Fault Zone north and south of Lasuen Knoll. The San Gabriel Transtensional Zone, north of Lasuen Knoll, separates the knoll from the Palos Verdes Anticlinorium, the other major uplift structure along the Palos Verdes Fault. The Lasuen Knoll basement high, the overall structural high that includes Lasuen Knoll, is similar in dimension and shape to the Palos Verdes Anticlinorium, which has been interpreted to be underlain by a low-angle ramp fault. Recent models of low-angle ramp faults as major causes of the uplift of Palos Verdes, however, cannot be readily applied to Lasuen Knoll.
On the Relationship among Submarine‐Channel Stacking Patterns, Environmental Controls during Deposition, and Reservoir Architecture: Case Studies of Three Neogene Outcrops in Southern California
Authors: Pyles David R. , Schwartz Daniel E. , Bouroullec Renaud , Jennette David C. , Gordon Gregory S.
Published: May 2020

A quantitative model for categorizing submarine-channel stacking patterns is developed and applied to well-exposed outcrops of Neogene-aged submarine channels in the Capistrano and upper Monterey formations, Southern California. Three outcrops are characterized in terms of their stratigraphic architecture: (1) Point Fermin, (2) Dana Point Harbor, and (3) San Clemente State Beach. Each outcrop has a unique channel-stacking style. The channel elements at Point Fermin stack in a vertical, disorganized pattern; the channel elements at Dana Point Harbor stack in a mixed vertical–lateral, disorganized pattern; and the channel elements at San Clemente State Beach stack in a predominantly lateral, organized pattern. The different stacking styles are compared and contrasted using a method that quantifies channel-stacking patterns by normalized vertical and lateral offset. First-order controls on channel-stacking patterns are interpreted to be position on the physiographic profile, accommodation regime, and/or local changes in subsidence due to syndepositional faulting. The discrete channel-stacking patterns in the three outcrops closely relate to parameters relevant in subsurface reservoir characterization, such as net-sand content, connectivity of channel elements, and preservation potential.
Quantitative Digital Petrography: A Novel Approach to Reservoir Characterization
Authors: Buono Antonio , Peterson Keith , Luck Kelly , Fullmer Shawn , Moore Paul J.
Published: May 2020

Carbonate reservoirs are often comprised of a heterogeneous pore system within a matrix of variably distributed minerals including anhydrite, dolomite, and calcite. When describing carbonate thin sections, it is routine to assign relative abundance levels to each of these components, which are qualitative to semiquantitative (e.g., point counting) and vary greatly depending on the petrographer. Over the past few decades image analysis has gained wide use among petrographers; however, thin-section characterization using this technique has been primarily limited to quantifying the pore space due to the difficulty associated with optical recognition beyond the blue-dyed epoxy associated with the pores. Here, we present a new method of computerized object-based image analysis (Quantitative Digital Petrography: QDP) that relies on a predefined rule set to enable rapid, automated thin-section quantification with limited interaction of a petrographer. We have developed a novel work flow that automatically isolates the sample on a high resolution (i.e., <1 μm/pixel) scanned thin section, segments the image, and assigns those segments to predefined categories; e.g., pores, cement, and grains. With this technique, statistically relevant numbers of thin sections can be rapidly batch processed and quality controlled, thereby allowing quantitative data from conventional core analysis, special core analysis, and reservoir surveillance to be integrated with the petrographic data for a more dynamic description of the carbonate rock. Our technique can also incorporate multiple layers, such as cross-polarization, backscatter electron imaging, and elemental maps, which allow additional information to be easily integrated with results from QDP. The QDP approach is a significant improvement over previous digital image analysis methods because it (1) does not require binarization, (2) eliminates the subjectivity in assessing abundance levels, (3) requires less interaction with a petrographer, and (4) provides a much fuller dataset that can be incorporated across an entire well or field to better address common challenges associated with carbonate reservoir characterization, such as understanding pore type and cement abundance, pore connectivity, grain distribution, and reservoir flow characteristics.
A European Field Assessment of the efficacy of fluralaner (Bravecto®) chewable and spot-on formulations for treatment of dogs with generalized demodicosis
Authors: Petersen Ivo , Chiummo Rafael , Zschiesche Eva , Karas-Tecza Joanna , Rapti Dhimiter , Roepke Rainer , Thomas Emmanuel
Published: May 2020

Background : Recent reports indicate that the isoxazoline compounds have the potential to provide safe and effective treatment of canine generalized demodicosis, a condition that has been traditionally difficult to cure. Controlled field studies are needed to confirm this potential. A study was therefore initiated to investigate the efficacy of a single oral or spot-on treatment with fluralaner, an isoxazoline, compared with multiple topical treatments with imidacloprid-moxidectin, in dogs naturally affected by generalized demodicosis. Methods : Veterinary clinics in 5 European countries enrolled 134 dogs diagnosed with generalized demodicosis. Dogs were randomized to treatment with either fluralaner chewables, fluralaner spot-on, or topical imidacloprid-moxidectin in a 2:2:1 ratio. Both fluralaner formulations were administered once, at the approved dose rate, on day 0. Imidacloprid-moxidectin was administered per label on day 0, and every 4 weeks, more frequently if necessary. At each visit (days 0, 28, 56, 84), dogs were monitored for demodectic mites, using deep skin scrapings, and observed for health and for severity of skin lesions. Treatment was considered efficacious if more than 90% of the dogs were free of live mites at both days 56 and 84. Results : Of 124 dogs completing the study, 57 were diagnosed with juvenile-onset demodicosis and 67 with the adult-onset form. A single treatment with oral or spot-on fluralaner was efficacious, each eliminating mites from at least 98.0% of treated dogs on days 56 and 84. Against juvenile-onset demodicosis, efficacy of the oral and spot-on formulations was 96.0% and 100%, respectively, and against adult-onset demodicosis 100% and 96.7%. Multiple administrations of imidacloprid-moxidectin were not efficacious, eliminating mites from 87.5% of dogs (92.0% with juvenile-onset demodicosis cured; 81.8% with adult-onset demodicosis). All groups showed a marked reduction in skin lesions by day 28, with continuing clinical improvement at each subsequent visit through day 84. There were no treatment-related adverse events. Conclusion : A single administration of fluralaner chewables or fluralaner spot-on is highly effective against juvenile-onset and adult-onset forms of generalized canine demodicosis. Topically applied imidacloprid-moxidectin at weekly to monthly intervals over the 84-day study did not achieve the proportion of mite-free dogs required to demonstrate efficacy.
Pre-stroke adherence to a Mediterranean diet pattern is associated with lower acute ischemic stroke severity: A cross-sectional analysis of a prospective hospital-register study.
Authors: Lavados Pablo M. , Mazzon Enrico , Rojo Alexis , Brunser Alejandro M. , Olavarría Verónica V.
Published: May 2020

Background: High adherence to a Mediterranean Diet is associated with reduced incidence and mortality of acute ischemic stroke (AIS) but may also be associated with severity.Aim: To investigate the association of adherence to a Mediterranean diet and severity in a prospective hospital register of AIS patients.Methods: We included AIS patients admitted from February 2017 to July 2019. All were assessed by a neurologist with a standard stroke protocol, including NIHSS. Adherence to Mediterranean diet was prospectively measured by the 14-point Mediterranean Diet Adherence Screener (MEDAS) and defined as low (0-6 points) or high (7-14 points). Demographic and clinical characteristics were compared by group with univariate analysis. A Generalized Linear Model (GLM) was used to investigate the association of admission NIHSS as a continuous ordinal variable and an ordinal logistic regression (OLR) analysis to determine the independent association of the NIHSS quartiles with adherence to Mediterranean diet. Results: 368 patients were included, mean age 68.3 (17.7), 158 (42.9%) females. The median NIHSS score was 3 (IQR 1-9) and the median MEDAS score was 6 (IQR 4.5-8). Patients with high MEDAS scores had significantly lower; admission NIHSS scores, sedentary lifestyle, body mass index, total and LDL cholesterol levels, but higher alcohol consumption. After adjustments, high adherence to Mediterranean diet remained independently associated with lower stroke severity both in the GLM (β coefficient = -0.19, p=0.01) and in the OLR model (OR for lower NIHSS quartiles 0.6 (95% CI 0.37-0.98, p=0.04). Conclusions: Higher pre-stroke adherence to a Mediterranean diet is independently associated with lower AIS severity.
Multilevel resistive switching memory based on a CH3NH3PbI3-xClx film with potassium chloride additives
Authors: Lv Fengzhen , Ling Kang , Zhong Tingting , Liu Fuchi , Liang Xiaoguang , Zhu Changming , Liu Jun , Kong Wenjie
Published: May 2020

High-quality CH3NH3PbI3-xClx (MAPIC) films were prepared using potassium chloride (KCl) as an additive on indium tin oxide(ITO)-coated glass substrates using a simple one-step and low-temperature solution reaction. The Au/KCl-MAPIC/ITO/Glass devices exhibited obvious multilevel resistive switching behavior, moderate endurance, and good retention performance. Electrical conduction analysis indicated that the resistive switching behavior of the KCl-doped MAPIC films was primarily attributed to the trap-controlled space-charge-limited current conduction that was caused by the iodine vacancies in the films. Moreover, the modulations of the barrier in the Au/KCl-MAPIC interface under bias voltages were thought to be responsible for the resistive switching in the carrier injection trapping/detrapping process.
miR-128-3p enhances the protective effect of dexmedetomidine on acute lung injury in septic mice by targeted inhibition of MAPK14
Authors: Ding Li , Gao Xiang , Yu Shenghui , Sheng Liufang
Published: May 2020

Background: To investigate the mechanism of miR-128-3p and MAPK14 on the protective effect of dexmedetomidine on acute lung injury in septic mice.Methods: SPF C57BL/6 mice were divided into 8 groups. The pathological changes and wet/dry weight ratio (W/D), PaO2, PaCO2, MDA, SOD and MPO levels in lung tissue and the serum levels of inflammation factors were observed. Dual luciferase reporter assay was used to verify the targeting relationship between miR-128-3p and MAPK14. qPCR and WB were used to detect the expression of miR-128-3p and MAPK14.Results: Compared with the Normal group, other groups had lower MDA, MPO, inflammatory factors levels and the expression level of MAPK14, while the content of SOD and the expression level of miR-128-3p was significantly decreased. DEX treatment and up-regulation of miR-128-3p could significantly decrease the contents of MDA, MPO, inflammatory factor levels and significantly increase the SOD content in model mice, however, MAPK14 over-expression had opposite effects. miR-128-3p up-regulation enhanced the changes of above indicators caused by DEX treatment and MAPK14 over-expression could block the protective effect of DEX on acute lung injury in septic mice. miR-128-3p up-regulation reversed the effects of MAPK14 over-expression in model mice.Conclusion: miR-128-3p can further enhance the protective effect of dexmedetomidine on acute lung injury in septic mice by targeting and inhibiting MAPK14 expression.
Efficacy evaluation of photodynamic therapy for oral lichen planus: a systematic review and meta-analysis
Authors: He Yuqing , Deng Jiaxin , Zhao Yi , Tao Huiqian , Dan Hongxia , Xu Hao , Chen Qianming
Published: May 2020

Background Photodynamic therapy (PDT) is a new option for oral lichen planus (OLP) management; however, there are different opinions on the efficacy of PDT for OLP. The aim of this study was to comprehensively assess the efficacy of PDT in the treatment of OLP and compare PDT with steroid therapy. Methods A systematic review and meta-analysis were conducted to assess the curative effect of PDT. Five electronic databases were searched, PubMed, Web of Science, the Cochrane Library, Embase, and EBSCO up to 1 December, 2019. Random and fixed effects models for pooled estimates calculation were used and the Meta package of R was applied. Results Pooled estimates revealed that, after PDT, the lesion size decreased by 1.53 cm2 (95% confidence interval (CI): 0.71–2.35) after PDT and the partial response (PR) was 0.77 (95% CI: 0.65–0.85). The visual analogue scale (VAS) score decreased by 3.82 (95% CI: 2.80–4.85) and the Thongprasom sign score decreased by 1.33 (95% CI: 0.56–2.10) after PDT. Subgroup analyses revealed that the 5-aminolevulinic acid (5-ALA) was more effective than methylene blue (MB), with a PR of 0.87 (95% CI: 0.80–0.91). The topical use of 5-ALA yielded a better response than gargling methylene blue. In terms of VAS, the diode laser showed a better clinical PR in the treatment of OLP. In terms of changes in lesion size, the efficacy of the semiconductor laser was higher than that of the diode laser. PDT had a similar efficacy to topical corticosteroids, as shown by pooled estimates of five randomised controlled trials with 139 lesions. Conclusion PDT could be a valuable optional treatment for the management of OLP. And the results indicated that the curative effect of PDT is similar to that of topical corticosteroids in the treatment of OLP.
Impact of Mouse Strain and Sex when Modeling Radiation Necrosis
Authors: Boria Andrew J. , Perez-Torres Carlos
Published: May 2020

Background: Murine models are among the most common type of preclinical animal models used to study the human condition, but a wide selection of different mice is currently in use with these differences potentially compromising study results and impairing the ability to reconcile interstudy results. Our goal was to determine how the train and sex of the mice selection would affect the development of radiation necrosis in our murine model of radiation-induced cerebral necrosis. Methods: We generated this model by using a preclinical irradiator to irradiate a sub-hemispheric portion of the brain of mice with single-fraction doses of 80 Gy. Eight possible combinations of mice made up of two different with two substrains each(BALB/cN, BALB/cJ, C57BL/6N, and C57BL/6J) and both sexes were irradiated in this study. Radiation necrosis development was tracked up to eight weeks with a 7T Bruker MRI utilizing T2-weighted and post-contrast T1-weighted imaging. MRI results were compared to and validated with the use of histology which utilized a scale from 0-3 in ascending order of damage. Results: Both time post-irradiation and strain (BALB/c vs C57BL/6) were significant factors affecting radiation necrosis development. Sex was in general not a statistically significant parameter in terms of radiation necrosis development. Conclusion: Mouse strain thus need to be considered when evaluating the results of necrosis models. However, sex does not appear to be a variable needing major consideration.