bluuebunny/crossref_metadata_2025 huggingface dataset:
Políticas educativas en universidades ecuatorianas para atender a estudiantes migrantes venezolanos
Authors: Pinzón Barriga Luis Enrique , Bernal Luna Claudia Patricia , Montecé Quiguango Efrén Armando
Published: May 2022

Introducción. En la actualidad la gran movilización de venezolanos hacia países de Latinoamérica se ha convertido en tema de preocupación, por lo que gobiernos y organismos internacionales han reconocido esta problemática abordándola y brindando soluciones a través de normativas migratorias y de derechos humanos. Asimismo, el desequilibrio social que sufren los migrantes, les conlleva a tropezar en la continuidad de su formación educativa. Objetivo. El objetivo de este artículo es discernir sobre las políticas que se han desarrollado en el Ecuador en cuanto a la atención de migrantes venezolanos en el sistema educativo superior. Metodología. Se realizará a través de una revisión documental de leyes y normativas nacionales e internacionales que enmarcan la inserción y apoyo para migrantes venezolanos. Resultados. En esta publicación se analizan y brindan aportes sobre los organismos que han trabajado con la problemática de la migración venezolana y sus repercusiones en la región latinoamericana y las políticas que ha tomado el Ecuador para coadyuvar con la gran cantidad de personas venezolanas que se encuentran en el país, las reglamentaciones que los benefician en cuanto a derechos humanos, oportunidades de estudio, y las estrategias que se han tomado en consideración para brindarles experiencias satisfactorias para establecerse y seguir adelante como ciudadano del mundo. Conclusión. El recorrido por leyes, normas y sistema de gestión de recursos para la educación que posee el Ecuador, desde el Grupo de Lima, La Constitución del Ecuador, la Ley de Organización del Movimiento de la Población y las políticas educativas de cada universidad aún deben promocionar cada vez más las estrategias de inclusión, multiculturalidad y enriquecimiento que beneficien al migrante y por ende al país, permitiéndole a las personas migrantes venezolanas tener una vida normal y que a través de estos beneficios puedan colaborar con el desarrollo socio-educativo y cultural del país.
Maternal Near Miss in A Tertiary Care Hospital : An Observational Study
Authors: Surovi Farjana Ahmed , Noor Serajun , Ali SM Ishtiaque , Sultana Aklima
Published: May 2022

Background: The term maternal near miss refer to women who have escaped death either by chance or due to good health care after experiencing severe life threatening complications during pregnancy, labour and within six weeks after termination of pregnancy. Severe Acute Maternal Morbidity (SAMM) or Maternal Near Miss (MNM) is a complement of maternal mortality. The aim of this study is to state the need of patient’s health education, importance of emergency transportation as well as to evaluate the standard of effective quality & evidence based care in the facility to reduce maternal mortality and morbidity.

Materials and methods : This observational study conducted for the period of January to December 2019 at Chattogram Maa-O-Shishu Hospital Medical College (CMOSHMC). Among 8976 total patients, MNM were 44 and total Maternal Death (MD) 13. Maternal Near miss clinical criteria – haemorrhage, hypertensive disorder of pregnancy, dystocia, sepsis & severe anaemia, organ dysfunction, based on management of ICU, blood transfusion, Maternal near miss are used to indicate quality of health care. Exclusion criteria- maternal death.

Results: Total admitted patients in Obs & Gynae department in this study period were 8976. Obstetric patient 7422 & total deliveries 6027. MNM 44 in number & MD were 13. Main causes of MNM were hypertensive disorders (Severe preeclampsia, Eclampsia, HELLP syndrome)-23 (52.3%), obstetric haemorrhage (Placenta praevia, abruption placenta, rupture uterus, rupture ectopic pregnancy, incomplete abortion with shock, DIC)-14 (31.8%) Cardiopulmonary dysfunction (Cardiac arrest, cardiomyopathy, heart failure) – 7 (15.9%). Among the 44 near miss management, LSCS – 32 (73%) vaginal deliveries – 4 (9%), laparotomy – 5 (11%), peripartum hysterectomy – 3 (7%). Women with life threatening condition (MNM & MD) – 57. MNM ratio 6.8 per thousand live birth, MNM & MD ratio – 3.4:1

Conclusion : SAMM or MNM is a pro-indicator to improve quality of obstetric care. Monitoring the near miss morbidity in conjunction with mortality surveillance could help to identify effective preventable measure for potentially life threatening morbidity.

Chatt Maa Shi Hosp Med Coll J; Vol.21 (1); January 2022; Page 57-60
Seroprevalence of Chikungunya Virus Infection in an Urban Slum Population of Bangladesh: A Cross-Sectional Study
Authors: Islam Mohammad Tanvir , Haque M Atiqul , Anjum Afifa , Nessa Afzalun , Rayna Shahrin Emdad , Sultana Sharmin , Khan Fahmida Afroz , Samin Sharraf , Khalequzzaman Md
Published: May 2022

Background: Chikungunya virus is common in Bangladesh.
Objective: The aim of the study was to estimate the post-outbreak seroprevalence of chikungunya virus infection in a Bangladeshi urban slum population.
Methodology: From April to May 2018, a cross-sectional study was conducted in Bauniabadh, an underprivileged slum area in Mirpur Thana (subdistrict), Dhaka, Bangladesh. Randomly selected residents of this area were interviewed and screened for chikungunya IgM and IgG antibodies in sera using the immunochromatographic process.
Results: Randomly selected 403 residents were recruited of which 200 cases were male and 203 cases were female. Chikungunya seroprevalence was 4.7% cases with males being more vulnerable than females (6.5% vs. 3.0% ). People over the age of 60 years were found to be infected at a higher rate (7.2%) than people between the ages of 18 and 59 years (5.5%) and those in the pediatric age group (1%). During the outbreak, 22% of patients with joint pain and 17% with fever were diagnosed as having chikungunya. Conclusion Urban slum people, especially the elderly, are affected by chikungunya outbreak in Bangladesh characterized by fever and joint pain.
Journal of Current and Advance Medical Research, January 2022;9(1):3-8
How accurately does the Australian Immunisation Register identify children overdue for vaccine doses? A national cross-sectional study
Authors: Dalton Lauren G , Meder Kelley N , Beard Frank H , Dey Aditi , Hull Brynley P , Macartney Kristine K , McIntyre Peter B
Published: May 2022

The accuracy of data recorded in the Australian Immunisation Register (AIR) is important for assessment of population-level vaccine coverage but has not been assessed nationally since 2001. We undertook a cross-sectional study in five states in 2017 using standard criteria to validate AIR records classified as three months overdue for any vaccine at 12, 24 and 48 months. Of 2,000 records selected for audit, 905 were assessable, of which 124 (14%) were misclassified as overdue (errors). Among 563 general practice (GP) records, 91 (16.1%) were errors. Compared with Victoria (1/99; 1%), errors were significantly higher in Western Australia (11/106; 10.4%), Queensland (13/104; 12.5%), South Australia (23/110; 20.9%) and New South Wales (43/144; 29.9%); p < 0.01 for all. Among 165 council and community health centre providers, the overall error rate (17; 10.3%) was non-significantly lower than for GP providers, with an odds ratio (OR) of 0.6 and a 95% confidence interval (95% CI) of 0.3–1.1, and did not differ between states. Records were transmitted to the AIR by paper-based methods in 13 cases, with significantly higher error rates (7/13; 54%) than for practice management software (77/630; 12.2%); OR 9.8 (95% CI 2.8–36.4) or the AIR secure site (23/87; 26.4%); OR 2.6 (95% CI 1.4–4.5). Accuracy is increasingly important, with mandatory reporting to the AIR for all National Immunisation Program vaccines from July 2021, and best achieved by uniform use of practice management software.
Two Treponema pallidum strains account for the majority of syphilis infections, including among females, in Queensland, Australia
Authors: Sweeney Emma L , Lowry Kym , Seel Mandy , Rahimi Frashta , Langton-Lockton Julian , Bletchly Cheryl , Nimmo Graeme R , Whiley David M
Published: May 2022

An ongoing outbreak of syphilis in Australia, first reported in the state of Queensland in 2011, has led to increasing cases of congenital syphilis, including several deaths. Here, we applied multi-locus sequence typing (MLST) on available Treponema pallidum PCR-positive samples from the state of Queensland from the beginning of the outbreak to July 2020. In total, 393 samples from 337 males and 56 females were genotyped. Of 36 different Treponema pallidum sequence types (ST) observed, the two most common STs, ST 1 (also reported to be a dominant strain in various other countries) and ST 100 (the latter differing from ST 1 by only one single nucleotide polymorphism (SNP) based on the MLST scheme), together comprised 69% (271/393) of all samples, including the majority of samples in females (79%; 44/56). ST 1 was prevalent throughout the entire study period. Both strains remained the most common STs during the year 2020 where social distancing and other measures were implemented due to the COVID-19 pandemic. Both STs had high male-to-female ratios and included male rectal infections, therefore suggestive of occurrence primarily among men-who-have-sex-with-men (MSM). Hence, bridging from MSM to heterosexual networks may potentially contribute to infections among females, but further studies are needed to confirm this. Overall, there was considerable diversity of Treponema pallidum genotypes observed throughout the study period, but the fact that two key strains accounted for the majority of infections, including among females, stresses the need for further investigations into the transmission of these strains, and potentially a need for targeted public health interventions to better control the spread of syphilis in Queensland.
“Scary to get, more scary not to”: COVID-19 vaccine acceptance among healthcare workers in Central Queensland, Australia, a cross-sectional survey
Authors: Chapman Gwenda , Al Imam Mahmudul Hassan , Khan Arifuzzaman , Smoll Nicolas , Adegbija Odewumi , Kirk Michael , Khandaker Gulam , Wiley Kerrie
Published: May 2022

Background Behavioural and social drivers (BeSD) of coronavirus disease 2019 (COVID-19) vaccine acceptance among Australian healthcare workers (HCW) living and working in regional areas are not well studied. Understanding local HCWs’ COVID-19 risk perceptions and potential barriers to COVID-19 vaccine uptake is crucial in supporting rollout. We aimed to understand the COVID-19 vaccine drivers among HCW in Central Queensland (CQ), Australia. Method A cross-sectional online survey of HCWs in CQ between 17 May and 31 May 2021, based on the BeSD framework adapted from the World Health Organization (WHO) Data for Action guidance, consisting of the five instrument domains: what people think and feel; social processes; motivations; practical issues; and vaccination uptake. Results Of the 240 responding HCWs within Central Queensland Hospital and Health Service, 78% were female. Of the participating HCWs, 64% percent had received at least one dose of a COVID-19 vaccine; of those who had not yet received a vaccine, 53% said they were willing to receive one. Factors associated with vaccine acceptance included: belief that the vaccine was important for their health (81%; odds ratio (OR): 7.2; 95% confidence interval (CI): 3.5–15.5); belief that their family and friends wanted them to have the vaccine (64%; OR: 6.7; 95% CI: 2.9–16.7); trust in the vaccine (72%; OR: 6.4; 95% CI: 3.5–12.0); and confidence in being able to answer patients’ questions about the vaccine (99%). Conclusions These findings suggest that a combination of communications and educational material framed around the benefits and social norms of vaccination, along with materials addressing vaccine safety concerns, will encourage HCW to take up a COVID-19 vaccine.
Penelitian Pendahuluan: Pelatihan Pemeriksaan Payudara bagi Tenaga Medis RS. Kanker Dharmais
Authors: Kardinah Kardinah , Sutjipto Sutjipto , Suzzana Evlina
Published: May 2022

Indonesia mempunyai masalah yang sama dengan negara berkembang lainnya yaitu pasien kanker payudara yang datang ke rumah sakit dalam stadium lanjut. Oleh karena itu diperlukan upaya peningkatan kepedulian khususnya di lingkup tenaga medis terhadap kanker payudara melalui penyuluhan dan ketrampilan pemeriksaan payudara. Tujuan penelitian ini adalah mengumpulkan data awal untuk menentukan metode yang tepat untuk pelatihan pemeriksaan payudara bagi tenaga medis khususnya perawat, bidan dan dokter umum.Dilakukan penyuluhan bagi staf medis yang berminat dan pelatihan pemeriksaan payudara pada tenaga medis (perawat dan bidan) di RS.Kanker Dharmais periode April - Desember 2005. Untuk meningkatkan kepedulian dan kemampuan ketrampilan pemeriksaan payudara para peserta kemudian diminta untuk memberikan penyuluhan di lingkungannya dan mengajak wanita yang bersedia dilakukan pemeriksaan payudara dan USG payudara di RS. Kanker Dharmais.Sebanyak 25 orang perawat dan bidan serta 1 orang dokter umum yang berpartisipasi aktif, 856 wanita bersedia dilakukan pemeriksaan payudara dan USG payudara. Pemeriksaan payudara oleh tenaga medis yang telah dikonfirmasi dengan USG payudara ditemukan hasil normal 783 ( 91.5 %) dan 73 (8.5%) abnormal. Adapun dari hasil abnormal tersebut adalah 39 (53.4%) kista, 17 (23.3%) lesi solid benigna dan 8 (10.9%) dicurigai maligna. Sedangkan kelainan payudara lain yang ditemukan adalah mastitis, galactocele, duktal ektasis serta mamaria aberans.Pelatihan pemeriksaan payudara membutuhkan tidak hanya pengetahuan dan ketrampilan pemeriksaan payudara tetapi juga ketrampilan berkomunikasi dan menjalin kerjasama dengan para wanita di lingkungannya sehingga partisipasi masyarakat dapat ditingkatkan.Kata kunci: kanker payudara, deteksi dini, pemeriksaan payudara, USG payudara.
Plastic bottle feeding produces changes in biochemical parameters in human infants – A pilot study
Authors: Pant Mahendra K. , Ahmad Abul. H. , Naithani Manisha , Pant Jayanti
Published: May 2022

Background: Plastic bottles are widely used by people to feed their infants when breastfeeding is not possible. Bisphenol A (BPA), an endocrine disruptor is widely used in the manufacturing of plastic wares and is leached out from these plastic wares on exposure to high temperature, changed pH, or cleaning the plastic wares by harsh detergents.Purpose: Feeding through plastic bottles over prolong duration is expected to expose the infants to leached BPA. Hence the present study was taken up to compare the effects of breastfeeding and plastic bottle feeding on biochemical parameters in infants and also detect for the presence of free BPA or its metabolite in the infants.Methods: Biochemical tests like lipid profile, liver function tests, creatine-kinase–MB (CK-MB), serum urea, serum electrolytes were performed on blood samples obtained from infants who were breastfed and plastic bottle fed. Further, plasma and urine samples of the infants were subjected to Liquid chromatography-mass spectrometry analysis for detecting free BPA and BPA glucuronide.Results: Biochemical changes in form of raised triglycerides, cholesterol, low-density lipoproteins, very low-density lipoproteins and increase in CK-MB, serum urea were observed in plastic bottle fed infants. BPA glucuronide was also detected in the urine of these infants. Free BPA was not detected in plasma or urine samples of the infants except in one plasma sample from bottle-fed group.Conclusion: Plastic bottle feeding may lead to toxic changes in the functioning of organs which manifest as altered biochemical parameters.
The effect of different antioxidants on nitric oxide production in hypertensive rats
Authors: Kojšová S , Jendeková L , Zicha J , Kuneš J , Andriantsitohaina R , Pecháňová O
Published: May 2022

The imbalance between nitric oxide (NO) and reactive oxygen species (ROS) production appears to be a common feature of experimental and human hypertension. Previously, different antioxidants and/or scavengers of oxygen free radicals were shown to activate nitric oxide synthase (NO synthase, NOS) and to increase the expression of both endothelial and neuronal NO synthase isoforms leading to blood pressure reduction. On the other hand, various antihypertensive drugs have been documented to possess antioxidant properties, which may contribute to their beneficial effect on blood pressure. This review is focused on the effects of antioxidant treatment in different models of experimental hypertension with a special attention to the prevention of oxidative damage and the augmentation of NO synthase activity and expression of NOS isoforms.
Vascular effect of red wine polyphenols in chronic stress-exposed Wistar-kyoto rats
Authors: Púzserová A , Csizmadiová Z , Andriantsitohaina R , Bernátová I
Published: May 2022

Present study investigated the effect of red wine polyphenolic compounds (Provinols) on blood pressure (BP), nitric oxide synthase (NOS) activity and vascular function in Wistar-Kyoto (WKY) rats exposed to chronic social stress produced by crowding. Adult male rats were divided into four groups: control (480 cm(2)/rat), Provinols-treated (20 mg/kg/day, 480 cm(2)/rat), crowded (200 cm(2)/rat) and crowded treated with Provinols (20 mg/kg/day, 200 cm(2)/rat) for 8 weeks. No differences in BP were observed among the groups at the end of experiment, however, reduced BP was observed in Provinols-treated rats after 3 weeks of treatment. NOS activity in the aorta was significantly elevated in crowded rats, while Provinols alone had no effect on nitric oxide (NO) production. Acetylcholine-induced relaxation of the femoral artery was significantly improved in stressed and Provinols-treated rats vs. control, without significant changes in their noradrenaline-induced vasoconstriction. Interestingly, Provinols blunted the elevation of NO production and vasorelaxation during crowding. Increased endothelium-dependent vasorelaxation and NO synthesis in crowded rats may represent the adaptation mechanisms, resulting in unaltered blood pressure in stress-exposed normotensive rats. This study further demonstrated that elevated release of NO during chronic stress may be prevented by Provinols. Thus, Provinols might maintain equilibrium between endothelium-derived vasoconstrictor and vasodilator factors in stress.
Performance of Homebalance Test in an Assessment of Standing Balance in Elderly Adults
Authors: Kajzar J , Janatová M , Hill M , Otáhal J , Nechlebová E , Tichý M , Krejčí M
Published: May 2022

Balance control is a critical task of daily life, the ability to maintain upright posture becomes of particular concern during aging when the sensory and motor system becomes deteriorated. Falls contribute to the most deaths caused by injury within the aged population, and the mortality rate following a fall is drastically elevated. Longitudinal and reliable assessment of balance control abilities is a critical point in the prediction of increased risk of falling in an elderly population. The primary aim of the study was to evaluate the efficiency of the Homebalance test in the identification of persons being at higher risk of falling. 135 subjects (82 women and 53 men) with geriatric syndrome have been recruited and the Homebalance and the Tinetti Balance test were performed. Results of both tests strongly correlated proving the good performance of the Homebalance test. Standing balance declines with increasing body mass index in both genders. Analysis of fluctuations of the center of pressure (COP) revealed higher frequency and magnitude in mediolateral direction COP movements when compared women to men. A strong negative correlation has been found between Tinetti static balance score and the total length of the COP trajectory during the examination on Homebalance (r = -0.6, p<0.001). Although both methods revealed good performance in detecting balance impairment, Homebalance test possesses higher precision due to the continuous nature of COP-derived parameters. In conclusion, our data proved that the Homebalance test is capable to identify persons with impaired balance control and thus are at higher risk of falling.
Analisis Kemampuan Numerik Peserta Didik: Dampak Strategi Lightening The Learning Climate dan Tipe Kepribadian Keirsey
Authors: Supriadi Nanang , Komarudin Komarudin , Juana Nadya Amalia , Suherman Suherman
Published: May 2022

Abstrak. Kemampuan dasar numerik dalam mengoperasikan bilangan dengan penggunaan fungsi-fungsi hitung dasar memiliki peran penting dalam meningkatkan kecepatan, kecermatan, penalaran untuk menyelesaikan soal matematika. Penelitian kuantitatif ini mengkaji kemampuan numerik peserta didik dengan mengimplementasikan strategi lightening the learning climate (LLC) dan tipe kepribadian keirsey. Metode penelitian yang digunakan adalah quasi experimental design dengan jumlah sampel sebanyak 61 peseta didik. Teknik pengumpulan data yang digunakan adalah tes dan angket kepribadian keirsey. Hasil menunjukkan bahwa terdapat peningkatan kemampuan numerik matematis antara peserta didik yang dipengaruhi oleh strategi pembelajaran LLC, tidak terdapat peningkatan kemampuan numerik matematis antara peserta didik yang diakibatkan oleh tipe kepribadian keirsey, sedangkan tidak terdapat peningkatan kemampuan numerik matematis antara peserta didik yang diakibatkan oleh interaksi antara strategi LLC dan tipe kepribadian keirsey. Implementasi strategi LLC yang diberikan berdampak baik pada peningkatan kemampuan numerik peserta didik.Kata Kunci: Kemampuan Numerik Matematis; Kepribadian Keirsey; Lightening the Learning Climate.
Pengembangan Bahan Ajar Interaktif Berbasis Komputer pada Materi Bangun Ruang Sisi Datar untuk Siswa Kelas VIII SMP
Authors: Saputri Febiyana , Afgani Muhammad Win , Nizar Harisman
Published: May 2022

Abstrak. Bahan ajar yang interaktif sangat diperlukan dalam proses pembelajaran. Salah satu materi pada pembelajaran matematika yang memerlukan bahan ajar interaktif adalah bangun ruang sisi datar. Penelitian ini bertujuan untuk menghasilkan bahan ajar interaktif berbasis komputer pada materi bangun ruang sisi datar untuk kelas VIII SMP yang valid dan praktis. Penelitian ini menggunakan Development Research dengan dua tahapan, yaitu tahap preliminary dan tahap prototyping menggunakan alur formative evaluation yang terdiri dari self evaluation, expert review, one-to-one dan small group. Teknik pengumpulan data yang digunakan meliputi angket, wawancara, dan dokumentasi. Adapun instrumen yang digunakan meliputi lembar validasi dan angket kepraktisan. Subjek penelitian ini adalah siswa kelas VIII SMP . Hasil penelitian ini adalah bahan ajar berbasis komputer pada materi bangun ruang sisi datar yang tergolong valid berdasarkan lembar validasi dan komentar ahli. Validator menyimpulkan bahwa bahan ajar yang di kembangkan ini telah baik dari segi konten, desain, kualitas teknis dan menyatakan layak untuk diujicobakan. Sedangkan kepraktisan dari bahan ajar dinilai dari hasil angket respon siswa dan wawancara pada tahap one-to-one dan small group. Siswa menyatakan bahwa bahan ajar mudah digunakan,  membantu siswa menguasai materi bangun ruang sisi datar,  dan  tertarik untuk menggunakan bahan ajar berbasis komputer.Kata Kunci: Bahan Ajar, Penelitian Pengembangan, Bangun Ruang Sisi Datar
Pengembangan Media Pembelajaran Statistika SMA Kelas XII Menggunakan Articulate Storyline
Authors: Rosiyanti Hastri , Farahdiba Tarisha
Published: May 2022

Abstrak. Rendahnya motivasi belajar siswa pada saat pembelajaran daring menyebabkan kesulitan guru dalam mengajar statistika. Untuk mendukung dalam proses pembelajaran statistika, peneliti mengembangkan media pembelajaran berbasis articulate storyline dengan harapan media ini dapat meningkatkan motivasi belajar siswa. Penelitian ini menggunakan model penelitian Research and Development (R&D) dengan teori pengembangan ADDIE (Analysis, Design, Development, Implementation, Evaluation). Instrumen yang digunakan dalam penelitian ini berupa kuisioner dengan skala likert yang diberikan kepada validator dan pengguna dan uraian yang diberikan hanya kepada pengguna. Hasil penelitian menunjukkan bahwa media BATIK sangat valid dari hasil perhitungan rata rata skor oleh ahli media 97%, ahli materi dengan rata – rata skor 96%, dan ahli bahasa dengan rata – rata skor 96%. Penelitian ini di uji coba di salah satu SMA swasta di Jakarta dengan sasaran siswa dan guru kelas XII IPA. Pada tahap implementation, peneliti melakukan uji coba ke 4 siswa dan 1 guru dengan rata–rata skor pada penilaian siswa diperoleh 79,89% dengan kategori praktis. Pada tahap evaluation, peneliti melakukan uji coba ke 23 siswa dan 1 guru dengan rata–rata skor pada penilaian guru diperoleh 91,31% dengan kategori sangat praktis. Dengan demikian dapat disimpulkan bahwa media pembelajaran BATIK dapat diterapkan pada pembelajaran statistika dan diharapkan dapat bermanfaat kepada pihak–pihak terkait.Kata Kunci: Media pembelajaran, Statistika, ADDIE.
Human Resources Management in The Country’s Border Region Faces Industry 4.0 and The Covid-19 Pandemic
Authors: Siswanto Dwi Joko , Tegor Tegor , Haqiqi Fauzan , Yusmalina Yusmalina , Susanto Alpino
Published: May 2022

This study was to see how much influence mediation of mindset changes has on human resource development and economic growth. The study used questionnaire aids, from which the questionnaire results were processed with Smart PLS 3.0 and the Sobel test, which is used to look at the indirect influence of mediation variables. Respondents involved in this study were the Karimun Regency community, with as many as 120 respondents taken using random sampling techniques. The results of hypothesis testing in this study are: first, human resource development has a significant influence on economic growth with an influence value of 14,407, more significant than the value of t value 1.96; second, human resource development has a significant value in changing mindsets of 40,679, greater than the value of t value 1.96. Third, the variable change mindset significantly influences the economic growth of 11,696 and is greater than the value of t = 1.96. Fourth, there is a significant indirect influence between human resource development and economic growth mediated by a change in the mindset of 306.25, more significant than the value of t values of 1.96.
Leadership Cadre in Madrasah: Strategies for Finding The Ideal Leader in Islamic Educational Institutions
Authors: Subiyantoro Subiyantoro
Published: May 2022

This study aims to understand leadership regeneration at Madrasah Aliyah Asy-Syafi'iyah Kendari to produce ideal leaders for the advancement of the institution. This study uses a qualitative approach to phenomenology, where the researcher tries to understand the meaning behind the phenomena that occur in the field. The data collection technique is done through in-depth interviews, observation, and documentation. The data analysis was carried out in stages, including data collection, data reduction, data presentation, and conclusions. The study results indicate that regeneration in leadership in madrasas is essential to create ideal leaders and good governance. The role of regeneration, including the inheritance of good organizational values, guarantor of organizational sustainability, and learning facilities for new cadres and prospective leaders of Islamic educational institutions. The cadre refers to standardization and formalization of the division of labor and specialization, the hierarchy of authority, professionalization, and written documentation.
Adapting to Learning Services During Covid-19: A Risk Mitigation Review
Authors: Aziz Reva Abdul , Nurannisa Anti
Published: May 2022

The purpose of this study was to analyze online learning during the COVID-19 pandemic and its solutions at SDIT Insan Rahayu Rancaekek Bandung. This research uses a qualitative approach with a case study type, the data obtained through interviews, observation, and documentation. This study indicates that the implementation of online learning during the covid-19 pandemic has problems for teachers: weak mastery of information technology devices and limited access to student supervision. Students have problems related to the inactivity of students in participating in learning, limited supporting facilities, and internet network access. Meanwhile, parents have limited time to accompany their children during online learning. These problems can be overcome by increasing the competence of teachers' IT mastery as well as intensive supervision involving the role of parents who are also supervised by the school so that two important roles involved in children's education as well as on the side of assignments that are carried out manually can be completed without any problems.
Optimizing the Potential Resources of Tahfidz Al Qur'an Educational Institutions: Quality Management Review
Authors: Noor Hasni
Published: May 2022

This study aimed to determine the management of improving the quality of resources at the Tahfidz Al-Qur'an Al Haromain Banjarmasin Institute. This research is descriptive qualitative research, using interviews, observations, and documentation as data collection techniques. The data analysis is carried out in stages: data reduction, data display and concluding. The study results indicate that the Tahfidz Al-Qur'an Al Haromain Educational Institution has managed to improve the management of the quality of resources in its institution. Planning efforts for all resources are carried out; the supervisory process is also carried out on the management of human resources, leaders, teachers, students, and parents, then the management of financial resources for those who apply mandatory infaq and for those who have donors have the control of donations from outside donors, management facilities and infrastructure and others that are by the existing theory.
Anger Management in Improving Teacher Performance in School
Authors: Rozi Fathor , Baharun Hasan , Tohet Moch , Aini Qurrotul , Imamah Najmi Nurul
Published: May 2022

Anger is often a weapon for all creatures to defend their lives through the most natural way or mechanism, namely attacking other animals who are bullies or threats, not even a teacher, also has an angry agent like other living creatures. This study aims to examine anger management to manage anger for PAUD teachers to conduct the learning process calmly, not depressed, and not stressful for children. This research uses qualitative methods of this type of case study with a purposive sampling approach conducted at the Raudhatul Athfal Nurul Islam Kalibuntu Probolinggo institute. The informants in the study were principals, group A teachers, and group B teachers. Results from anger management research in improving teacher performance in schools show that first, analyze the causes of the problem. Second, personal approach and place oriented. Third, reflection so that every teacher knows the extent of their ability to manage anger. The implication is that teachers should remind each other in controlling emotions, especially when in the school environment.
Leadership and Principal Motivation on Teacher Performance at Madrasah
Authors: Jamilus Jamilus , Murtadlo Ghulam , Pahmi Pahmi , Indriani Dewi , Jasiah Jasiah
Published: May 2022

This study aims to determine the influence of leadership and principal motivation on teacher performance at Madrasah Tsanawiyah Thawalib, Tanjung Limau Pariangan, West Sumatra. This study uses a quantitative correlational approach that is commonly used to evaluate and detect the extent of a factor's variation on one or more other factors based on the correlation coefficient. This study involved 30 teachers. The results showed that leadership and motivation simultaneously affected teacher performance at Madrasah Tsanawiyah Thawalib with a significance value (sig) of 0.003. The better the leadership and the higher the motivation given by the head of the madrasah, it will improve teachers' performance in the madrasah. This study has implications for the importance of the leadership style displayed by the principal in improving the performance of existing personnel in the organization to achieve the desired goals.
Making use of transcription data from qualitative research within a corpus-linguistic paradigm: issues, experiences and recommendations
Authors: Collins Luke , Hardie Andrew
Published: May 2022

In this paper, we reflect on the process of re-operationalising transcript data generated in an ethnographic study for the purposes of corpus analysis. We present a corpus of patient–provider interactions in the context of Emergency Departments in hospitals in Australia, to discuss the process through which ethnographic transcripts were manipulated to generate a searchable corpus. We refer to the types of corpus analysis that this conversion enables, facilitated by the rich metadata collected alongside the transcribed audio recordings, augmenting the findings of prior qualitative analyses. Subsequently, we offer guidance for spoken data transcription, intended to ‘future proof’ such data for subsequent reformatting for corpus linguistic analysis.
Dermal integration of hyaluronic acid fllers: observation in real clinical practice
Authors: Yusova J. Yu. , Baranova E. L. , Demidion D. V. , Akhmedbaeva I. A. , Kruglova L. S.
Published: May 2022

A clinical observation of the dermal integration of low-concentration products based on hyaluronic acid produced by KPM and IPN-Like technologies is presented. KPM technology is a method of obtaining a cohesive poly-compacted gel matrix of hyaluronic acid, which determines the peculiarity of distribution in the skin due to particles of different densities in one product. On the one hand, the drug remains at the injection site after injection due to dense particles, on the other hand, translocation of loose particles into a more modifed part of the dermis. The clinical effect is manifested in the form of full integration of the drug into the dermis, imitating natural volumes. IPN-Like technology involves the preparation of a hyaluronic acid preparation from two monophase chains with low and high elasticity. Interpenetrating stabilized chains are obtained under pressure. Partial independence of IPN structures is necessary for the predicted integration and distribution of the drug in tissues, whereas the increased density of cross-linking nodes strengthens the intensity of the chemical bond, strengthens the fxation of the drug at the injection site. The study was conducted on seven patients using ultrasound scanning before the procedure, during the procedure to control the introduction into the required layer, 15 minutes after the procedure and 2 months later. To objectify the data, skin proflometry was used and photodocumentation in the designated time frame. In the presented clinical case, when comparing the distribution of fllers based on hyaluronic acid, it was revealed that all drugs are well distributed in the surface layers of the dermis, which makes it possible to safely inject drugs created using IPN-Like technology in the same techniques and to the same depth as the drug with CPM technology. According to ultrasound of the skin, drugs produced by IPN-Like technology showed greater effectiveness in terms of dermis thickness after 2 months.
Blue spectrum of light: Effects on skin and photoprotection
Authors: Kruglova L. S. , Shatohina E. A.
Published: May 2022

Ultraviolet radiation has a proven damaging and carcinogenic effect, while the blue spectrum of visible light has now been proven to contribute to damage to skin cells. Blue light causes an antiproliferative effect associated with oxidative stress, disruption of the permeability of the epidermal barrier, activates inﬂammation and the appearance of pronounced, prolonged hyperpigmentation. In this regard, when developing photoprotective agents, it is necessary to take into account the damaging effect of blue light. The frst full spectrum photoprotector is TriAsorB, which allows full protection of the skin from photodamage.
Atopic dermatitis and celiac disease as comorbid conditions in pediatric dermatology
Authors: Opryatin L. A.
Published: May 2022

Atopic dermatitis is a chronic dermatosis most often encountered in the practice of a pediatric dermatologist. Often, the skin process is difficult to treat, which may be due to gluten intolerance caused by celiac disease, and therefore requires the complete exclusion from the diet of products based on gluten-containing cereals: wheat, rye, barley. The article presents data indicating a high incidence of celiac disease among children with atopic dermatitis, exceeding the frequency in the general population. Given the above, patients with atopic dermatitis, especially those with persistent, torpid course, need to be screened for celiac disease, and if it is confrmed, they additionally need to be consulted by a nutritionist.
Trends and prospects of development of the cadastre of lands of the water fund of the Transcarpathian region
Authors:   Lviv Polytechnic National University, SAI V. , GUBAR Yu. ,   Lviv Polytechnic National University
Published: May 2022

The purpose of the proposed study is to comprehensively study the current state of the lands of the water fund of the Transcarpathian region, to identify trends and prospects for its development in a market economy. Method. Water resources play a significant socio-economic, environmental and biosphere role. Floodplains, as a kind of biogeocenoses and an integral part of modern landscapes, through the system of energy flows in them, carried out under the influence of living matter and various natural and anthropogenic factors, affect other types of ecosystems and the biosphere as a whole. The main problematic issues of land use are: disturbance of natural landscapes (slopes, beaches) as a result of intensive development of the coast, taking into account natural conditions; unreasonable construction of floodplains, which has exacerbated the crisis in their basins; plowing of lands within the coastal protection strips to the water's edge; deforestation, which is carried out primarily in the coastal areas of rivers, lakes, seas, reservoirs negatively affects the state of the lands of the water fund. To solve these problems, it is very important to study the rational use of water resources in artificial and natural terms, which will contribute to the preservation and reproduction of these vulnerable objects. Results. Features of land use of the water fund of the Transcarpathian region are considered. The component structure of the lands of the water fund and the peculiarities of its territorial differentiation are studied. The shares of artificial and natural water bodies in the Transcarpathian region have been determined. A detailed description of water fund lands and their structure, data on the area of land occupied by water bodies (rivers and streams, lakes and coastal closed reservoirs), hydraulic and other water facilities, as well as coastal protection strips, the distribution of water fund lands by land users, as well as the distribution of water fund lands within the administrative districts of the Zakarpattia region. Scientific novelty and practical significance. The analytical database of water fund lands, which contains accounting and reference data with territorial reference for the necessary analysis and synthesis of information in different territorial sections, will ensure the efficiency and reliability of detailed theoretical and practical studies of water fund lands for multiple and multi-purpose using.
Comparison Between Dichloroacetate and Phenylbutyrate Treatment for Pyruvate Dehydrogenase Deficiency
Authors: Karissa Patricia , Simpson Timothy , Dawson Simon P. , Low Teck Yew , Tay Sook Hui , Nordin Fatimah Diana Amin , Zain Shamsul Mohd , Lee Pey Yee , Pung Yuh-Fen
Published: May 2022

Pyruvate dehydrogenase (PDH) deficiency is caused by a number of pathogenic variants and the most common are found in the PDHA1 gene. The PDHA1 gene encodes one of the subunits of the PDH enzyme found in a carbohydrate metabolism pathway involved in energy production. Pathogenic variants of PDHA1 gene usually impact the α-subunit of PDH causing energy reduction. It potentially leads to increased mortality in sufferers. Potential treatments for this disease include dichloroacetate and phenylbutyrate, previously used for other diseases such as cancer and maple syrup urine disease. However, not much is known about their efficacy in treating PDH deficiency. Effective treatment for PDH deficiency is crucial as carbohydrate is needed in a healthy diet and rice is the staple food for a large portion of the Asian population. This review analysed the efficacy of dichloroacetate and phenylbutyrate as potential treatments for PDH deficiency caused by PDHA1 pathogenic variants. Based on the findings of this review, dichloroacetate will have an effect on most PDHA1 pathogenic variant and can act as a temporary treatment to reduce the lactic acidosis, a common symptom of PDH deficiency. Phenylbutyrate can only be used on patients with certain pathogenic variants (p.P221L, p.R234G, p.G249R, p.R349C, p.R349H) on the PDH protein. It is hoped that the review would provide an insight into these treatments and improve the quality of lives for patients with PDH deficiency.
Improved Cytocompatibility and Reduced Calcification of Glutaraldehyde-Crosslinked Bovine Pericardium by Modification With Glutathione
Authors: Jiang Zhenlin , Wu Zhongshi , Deng Dengpu , Li Jiemin , Qi Xiaoke , Song Mingzhe , Liu Yuhong , Wu Qiying , Xie Xinlong , Chen Zeguo , Tang Zhenjie
Published: May 2022

Bioprosthetic heart valves (BHVs) used in clinics are fabricated via glutaraldehyde (GLUT) crosslinking, which results in cytotoxicity and causes eventual valve calcification after implantation into the human body; therefore, the average lifetime and application of BHVs are limited. To address these issues, the most commonly used method is modification with amino acids, such as glycine (GLY), which is proven to effectively reduce toxicity and calcification. In this study, we used the l-glutathione (GSH) in a new modification treatment based on GLUT-crosslinked bovine pericardium (BP) as the GLUT + GSH group, BPs crosslinked with GLUT as GLUT-BP (control group), and GLY modification based on GLUT-BP as the GLUT + GLY group. We evaluated the characteristics of BPs in different treatment groups in terms of biomechanical properties, cell compatibility, aldehyde group content detection, and the calcification content. Aldehyde group detection tests showed that the GSH can completely neutralize the residual aldehyde group of GLUT-BP. Compared with that of GLUT-BP, the endothelial cell proliferation rate of the GLUT + GSH group increased, while its hemolysis rate and the inflammatory response after implantation into the SD rat were reduced. The results show that GSH can effectively improve the cytocompatibility of the GLUT-BP tissue. In addition, the results of the uniaxial tensile test, thermal shrinkage temperature, histological and SEM evaluation, and enzyme digestion experiments proved that GSH did not affect the ECM stability and biomechanics of the GLUT-BP. The calcification level of GLUT-BP modified using GSH technology decreased by 80%, indicating that GSH can improve the anti-calcification performance of GLUT-BP. Compared with GLUT-GLY, GLUT + GSH yielded a higher cell proliferation rate and lower inflammatory response and calcification level. GSH can be used as a new type of anti-calcification agent in GLUT crosslinking biomaterials and is expected to expand the application domain for BHVs in the future.
Reduction of Drosophila Mitochondrial RNase P in Skeletal and Heart Muscle Causes Muscle Degeneration, Cardiomyopathy, and Heart Arrhythmia
Authors: Saoji Maithili , Petersen Courtney E. , Sen Aditya , Tripoli Benjamin A. , Smyth Jeremy T. , Cox Rachel T.
Published: May 2022

In this study, we examine the cause and progression of mitochondrial diseases linked to the loss of mtRNase P, a three-protein complex responsible for processing and cleaving mitochondrial transfer RNAs (tRNA) from their nascent transcripts. When mtRNase P function is missing, mature mitochondrial tRNA levels are decreased, resulting in mitochondrial dysfunction. mtRNase P is composed of Mitochondrial RNase P Protein (MRPP) 1, 2, and 3. MRPP1 and 2 have their own enzymatic activity separate from MRPP3, which is the endonuclease responsible for cleaving tRNA. Human mutations in all subunits cause mitochondrial disease. The loss of mitochondrial function can cause devastating, often multisystemic failures. When mitochondria do not provide enough energy and metabolites, the result can be skeletal muscle weakness, cardiomyopathy, and heart arrhythmias. These symptoms are complex and often difficult to interpret, making disease models useful for diagnosing disease onset and progression. Previously, we identified Drosophila orthologs of each mtRNase P subunit (Roswell/MRPP1, Scully/MRPP2, Mulder/MRPP3) and found that the loss of each subunit causes lethality and decreased mitochondrial tRNA processing in vivo. Here, we use Drosophila to model mtRNase P mitochondrial diseases by reducing the level of each subunit in skeletal and heart muscle using tissue-specific RNAi knockdown. We find that mtRNase P reduction in skeletal muscle decreases adult eclosion and causes reduced muscle mass and function. Adult flies exhibit significant age-progressive locomotor defects. Cardiac-specific mtRNase P knockdowns reduce fly lifespan for Roswell and Scully, but not Mulder. Using intravital imaging, we find that adult hearts have impaired contractility and exhibit substantial arrhythmia. This occurs for roswell and mulder knockdowns, but with little effect for scully. The phenotypes shown here are similar to those exhibited by patients with mitochondrial disease, including disease caused by mutations in MRPP1 and 2. These findings also suggest that skeletal and cardiac deficiencies induced by mtRNase P loss are differentially affected by the three subunits. These differences could have implications for disease progression in skeletal and heart muscle and shed light on how the enzyme complex functions in different tissues.
Novel Insights in the Regulatory Mechanisms of Ferroptosis in Hepatocellular Carcinoma
Authors: Ma Shiwen , Adzavon Yao Mawulikplimi , Wen Xiaohu , Zhao Pengxiang , Xie Fei , Liu Mengyu , Ma Xuemei
Published: May 2022

Ferroptosis is a newly defined programmed cell death, which by its mechanism differs from other programmed cell death processes such as apoptosis, necrosis, and autophagy. It has a unique morphology and biological properties that antioxidants and iron-chelating agents can regulate. Ferroptosis has the characteristics of iron ion deposition and dependence on lipid peroxidation. It can affect the progression of many cancers, including liver cancer, by inducing an intracellular iron-dependent accumulation of reactive oxygen species, providing new possibilities for cancer treatment. At present, great progress has been made in exploring the molecular mechanism of ferroptosis. In this review, we summarize the characteristics, mechanisms, and regulatory factors of ferroptosis in detail, discuss the progress of ferroptosis research in liver cancer, and provide directions and new ideas for the treatment of hepatocellular carcinoma.