bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of an Enhanced Transtheoretical Model Intervention (ETMI) Workshop on the Attitudes and Beliefs Regarding Low Back Pain of Primary Care Physicians in the Israeli Navy
Authors: Besor Omri , Brand Ronen , Feldman Ron , Nudelman Yaniv , Shahar Yair , Finestone Aharon S. , Ben Ami Noa
Published: March 2023

Low back pain (LBP) is a major cause of discomfort and disability. Physicians’ attitudes and beliefs influence the way patients with LBP are diagnosed and treated. The objective of the study is the assessment of military primary care physicians’ attitudes towards LBP and the effect of an enhanced transtheoretical model intervention (ETMI) workshop on them. We evaluated the impact of a 90-min ETMI workshop on the attitudes and beliefs of primary care physicians in the Israeli Navy on LBP. Outcomes were assessed using the Attitudes to Back Pain Scale in Musculoskeletal Practitioners questionnaire (ABS-mp). Participants responded before and after the workshop, and responses were compared to a control group of primary care physicians in the Air and Space Force. The intervention group included 22 participants and the control group included 18 participants. Both groups were heterogenic (gender, age, seniority). In both groups, primary care physicians reported the common use of non-steroidal anti-inflammatory drugs (NSAIDs) and over-the-counter (OTC) pain medications and often included physical activity and physiotherapy in the treatment plan. Physicians mentioned reassurance and suggestions of early return to physical activity as part of their appointment. There was a positive correlation between questionnaire items suggesting the physician tended to a biomedical approach and reporting the use of imaging modalities (r = 0.451, p = 0.005). After attending the workshop, physicians were significantly more likely to recommend an early return to physical activity (18 ± 0.48 vs. 16.4 ± 0.52, p = 0.04). An ETMI workshop had a minor impact on the attitudes and beliefs of primary care physicians regarding LBP, but a statistically significant impact was noted on return to physical activity recommendations. These findings may be important in the military setting.
Sexually Transmitted Diseases among Saudi Women: Knowledge and Misconceptions
Authors: Malli Israa Abdullah , Kabli Basmah Abdullah , Alhakami Lujain Ali
Published: March 2023

The rate of sexually transmitted diseases is increasing globally. Thus, this study aimed to examine the Al akami female community’s knowledge about the nature of sexually transmitted diseases and their associated factors. The STDs-Knowledge Questionnaire (STDs-KQ) was utilized to collect data from the female community (355) in Jeddah, Saudi Arabia. The data were analyzed using JMP Statistics for Windows, version 15. The significance level was set at 0.05. The study reported that participants had a relatively low understanding of STDs in acquisition, protection, prevention, and clinical signs and symptoms; only 33 (9%) had high knowledge scores (10–18), while 70% thought one virus caused all forms of STDs. Also, only 15% of the respondents knew the clinical features of the Chlamydia infection, and 18% identified the correct mode of its transmission. Also, older participants with clinical exposure had a higher knowledge score than young and single females, p < 0.05. A positive correlation between age and knowledge score was reported, r (354) = 0.339, p < 0.0001. The low knowledge scores were associated with marital status, age, and clinical exposure. Practical strategies to minimize literacy toward sexual education and increase the quality of sexual life must be promoted by educators and the academic curriculum
Land Use Conflict Identification Coupled with Ecological Protection Priority in Jinan City, China
Authors: Dong Guanglong , Wang Jue , Zhang Wenxin , Liu Zheng , Wang Kehua , Cheng Weiya
Published: March 2023

Land use conflicts exacerbate soil erosion and reduce biodiversity, which is detrimental to sustainable development. Multiple methods such as multi-criteria evaluation and landscape pattern indexes can identify land use conflicts, but few studies conform to the concept of green development. The concept of green development gives priority to ecological protection and coordinates the relationship between production development, food production and ecological protection to achieve sustainable development. Taking Jinan City (China) as the study area, we identified the ecological source areas by evaluating the importance of ecosystem service functions and ecological sensitivity, then extracted and optimized the ecological corridor network (using the minimum cumulative resistance model and gravity model), and constructed the ecological security pattern. Spatial overlay analysis of cultivated land, construction land, and the ecological security pattern was performed to identify the types and intensity of land use conflicts. Spatially, we found that ecological land was in more serious conflict with cultivated land than construction land. Different types of land use conflicts have significant differences in spatial distribution. The key to land use conflict mediation in Jinan City is to balance food security with the improvements in the quality of the ecological environment. Hence, it is necessary to delineate the main functional zones and formulate tailored land use conflict mediation strategies in each zone. The method for land use conflict identification proposed here follows the principle of giving priority to ecological protection, providing a scientific reference for the utilization and protection of territorial space in other similar areas.
Is Climate Change Slowing the Urban Escalator Out of Poverty? Evidence from Chile, Colombia, and Indonesia
Authors: Nakamura Shohei , Abanokova Kseniya , Dang Hai-Anh H. , Takamatsu Shinya , Pei Chunchen , Prospere Dilou
Published: March 2023

While urbanization has great potential to facilitate poverty reduction, climate shocks represent a looming threat to such upward mobility. This paper empirically analyzes the effects of climatic risks on the function of urban agglomerations to support poor households’ escape from poverty. Combining household surveys with climatic datasets, our analyses of Chile, Colombia, and Indonesia find that households in large metropolitan areas are more likely to escape from poverty, indicating better access to economic opportunities in those areas. However, climate shocks such as extreme rainfalls and high flood risks significantly reduce upward mobility, thus offsetting such benefits of urban agglomerations. The findings underscore the need to enhance resilience among the urban poor to allow them to fully utilize the benefits of urban agglomerations.
The Relationship of Parent Support and Child Emotional Regulation to School Readiness
Authors: Lin Mei-Ling , Faldowski Richard A.
Published: March 2023

Using data from the longitudinal Early Head Start Research and Evaluation Project that were obtained when children were 14 through 60 months old, this study aims to explore the transactional effects between parent supportiveness and child emotion regulations skills. An autoregressive model with cross-lagged paths was utilized to examine the developmental trajectories of parent supportiveness and child emotion regulation, the directions of transactional relationships between them, and the transactional effects on the prediction of child cognitive school readiness. Significant autoregressive effects were found in both parent supportiveness and child emotion regulation trajectories. Significant concurrent and longitudinal transactional effects between these two processes were documented. The effects of child emotion regulation, parent supportiveness, and their transactional effects significantly predicted cognitive school readiness. This study exemplifies the use of archival longitudinal data to move beyond current unidirectional empirical understandings of child early psychosocial development toward more integrated perspectives. Equally important, the results provide critical insights for the timing of interventions as well as the involvement of parents in early intervention programs that early childhood educators and family services providers can benefit from.
System of Work and Stress-Coping Strategies Used by Nurses of a Polish Hospital during the COVID-19 Pandemic
Authors: Haor Beata , Antczak-Komoterska Anna , Kozyra Justyna , Grączewska Natalia , Głowacka Mariola , Biercewicz Monika , Królikowska Agnieszka , Jabłońska Renata , Grzelak Lech
Published: March 2023

The COVID-19 pandemic contributed to increased stress levels experienced by employees of the healthcare system during their professional activities. The aim of the study was to compare the stress-coping strategies used by nurses in two different systems of work (one shift/two shifts) in a Polish hospital in 2021. The study used the Polish adaptation of the Mini-COPE questionnaire and the authors’ data sheet. The results indicate that regardless of experience or the place and system of work, nurses more often chose problem-focused coping strategies. Conducting screening tests among nurses will help to establish effective strategies for coping with occupational stress, thus preventing professional burnout.
Effect of Combining Impact-Aerobic and Strength Exercise, and Dietary Habits on Body Composition in Breast Cancer Survivors Treated with Aromatase Inhibitors
Authors: Garcia-Unciti Marisol , Palacios Samper Natalia , Méndez-Sandoval Sofía , Idoate Fernando , Ibáñez-Santos Javier
Published: March 2023

This study examines both the effect of a twice-weekly combined exercise—1 h session of strength and 1 h session of impact-aerobic—on body composition and dietary habits after one year of treatment with aromatase inhibitors (AI) in breast cancer survivors. Overall, forty-three postmenopausal women with a BMI ≤ 35 kg/m2, breast cancer survivors treated with AI, were randomized into two groups: a control group (CG) (n = 22) and a training group (IG) (n = 21). Body composition, i.e., abdominal, visceral, and subcutaneous adipose tissue) was measured by magnetic resonance. In addition, some questionnaires were used to gather dietary data and to measure adherence to the Mediterranean diet. After one year, women in the IG showed a significant improvement in body composition, indicated by decreases in subcutaneous and visceral adipose tissue, and total fat tissue. Furthermore, the dietary habits were compatible with moderate adherence to the Mediterranean diet pattern and a low dietary intake of Ca, Zn, Folic Ac, and vitamins D, A, and E. A twice-weekly training program combining impact aerobic exercise and resistance exercise may be effective in improving the body composition for postmenopausal women who have breast cancer treated with AI, and the results suggest the need for nutritional counselling for this population.
Botulinum Toxin and Dynamic Splint Restore Grasping Function after Stroke: A Case Report
Authors: Moskiewicz Denis , Mraz Małgorzata , Chamela-Bilińska Dagmara
Published: March 2023

Evidence on the effectiveness of upper extremity rehabilitation post-stroke is inconclusive. We evaluated a tailored therapeutic program with dynamic splint and botulinum toxin injections for the treatment of upper extremity muscle spasticity. A case of a 43-year-old woman with chronic spastic hemiparesis after ischemic stroke with significant mobility impairment in the left upper extremity was described. A 16-week program consisted of three 50-min sessions daily and focused on grasping and releasing with and without the splint. The patient was evaluated before botulinum toxin injection and after 6, 12 and 16 weeks according to the International Classification of Functioning, Disability and Health, and included the following scales: Fugl-Meyer Upper Extremity Assessment (FMA-UE), Modified Ashworth Scale, Numerical Rating Scale (NRS), MyotonPro, Stroke Impact Scale, Box and Blocks. Photographic documentation made before and after the experiment was compared. Motor functions improved by 19.7% on FMA-UE, spasticity was reduced by one degree and pain at rest and during activity decreased by one score on NRS. A reduction in the oscillation frequency of the relaxed muscle and the stiffness of the examined muscles was observed. The patient regained grasping function. Health-related quality of life was systematically improving with a 35% increase at week 16 compared to the baseline. The combination treatment for spasticity based on botulinum toxin and SaeboFlex® dynamic splint in a patient with chronic spastic hemiparesis reduces disability and improves quality of life. However, further research is needed to investigate the treatment results.
Analysis of the Clinical Status and Treatment of Facial Cellulitis of Odontogenic Origin in Pediatric Patients
Authors: Słotwińska-Pawlaczyk Adrianna , Orzechowska-Wylęgała Bogusława , Latusek Katarzyna , Roszkowska Anna Maria
Published: March 2023

The most common cause of the development of odontogenic infection is untreated dental caries, which initially leads to pulpitis. If an odontogenic infection is left untreated, it will pass through the limiting bone plate and will infiltrate deeper structures. Odontogenic infections are different in adults and children. The study was conducted at the Department of Pediatric Otolaryngology and Pediatric Head and Neck Surgery of Upper Silesian Children’s Health Center in Katowice in the 2020–2022. We included 27 patients aged 2–16 in the study. Patients were diagnosed with an active, acute odontogenic inflammatory process in the head and neck area. We assessed pain, trismus, extraoral and intraoral swelling and the level of CRP [C Reactive Protein], WBC [White Blood Cells], NLR [Neutrophil Lymphocyte Ratio], D-dimers and Prealbumins. The results were analyzed in terms of the location of the source of inflammation: maxilla or mandible and the type of source of infection: deciduous tooth or permanent tooth. Deciduous teeth are more often the cause of odontogenic infection in the maxilla, while permanent teeth in the mandible. Trismus, extraoral, and intraoral swelling occurred in all infections caused by permanent teeth. The CRP and NLR ratio is statistically higher in infection, which originates from permanent teeth. The mean hospitalization time was also longer for infections from permanent teeth 3.42 days than for deciduous teeth 2.2 days. The varied clinical picture of odontogenic infections in children requires periodic analyzes of statistical data related to epidemiology, etiology, and symptomatology in order to update diagnostic and therapeutic procedures.
Determining the Impact of Heatwaves on Emergency Ambulance Calls in Queensland: A Retrospective Population-Based Study
Authors: Mason Hannah M. , King Jemma C. , Peden Amy E. , Watt Kerrianne , Bosley Emma , Fitzgerald Gerard , Nairn John , Miller Lauren , Mandalios Nicole , Franklin Richard C.
Published: March 2023

Heatwaves are a significant and growing threat to the health and well-being of the residents of Queensland, Australia. This threat is increasing due to climate change. Excess heat increases the demand for health services, including ambulance calls, and the purpose of this study was to explore this impact across Queensland. A state-wide retrospective analysis of heatwaves and emergency ‘Triple Zero’ (000) calls to Queensland Ambulance (QAS) from 2010–2019 was undertaken. Call data from the QAS and heatwave data from the Bureau of Meteorology were analysed using a case-crossover approach at the postcode level. Ambulance calls increased by 12.68% during heatwaves. The effect was greatest during low-severity heatwaves (22.16%), followed by severe (14.32%) and extreme heatwaves (1.16%). The impact varied by rurality, with those living in very remote areas and major cities most impacted, along with those of low and middle socioeconomic status during low and severe intensity heat events. Lag effects post-heatwave continued for at least 10 days. Heatwaves significantly increase ambulance call centre workload, so ambulance services must actively prepare resources and personnel to address increases in heatwave frequency, duration, and severity. Communities must be informed of the risks of heatwaves at all severities, particularly low severity, and the sustained risks in the days following a heat event.
Associations between Prenatal and Postnatal Exposure to Cannabis with Cognition and Behavior at Age 5 Years: The Healthy Start Study
Authors: Moore Brianna F. , Salmons Kaytlyn A. , Hoyt Adrienne T. , Swenson Karli S. , Bates Emily A. , Sauder Katherine A. , Shapiro Allison L. B. , Wilkening Greta , Kinney Gregory L. , Neophytou Andreas M. , Sempio Cristina , Klawitter Jost , Christians Uwe , Dabelea Dana
Published: March 2023

Background: Prenatal exposure to cannabis may influence childhood cognition and behavior, but the epidemiologic evidence is mixed. Even less is known about the potential impact of secondhand exposure to cannabis during early childhood. Objective: This study sought to assess whether prenatal and/or postnatal exposure to cannabis was associated with childhood cognition and behavior. Study design: This sub-study included a convenience sample of 81 mother–child pairs from a Colorado-based cohort. Seven common cannabinoids (including delta 9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD)) and their metabolites were measured in maternal urine collected mid-gestation and child urine collected at age 5 years. Prenatal and postnatal exposure to cannabis was dichotomized as exposed (detection of any cannabinoid) and not exposed. Generalized linear models examined the associations between prenatal or postnatal exposure to cannabis with the NIH Toolbox and Child Behavior Checklist T-scores at age 5 years. Results: In this study, 7% (n = 6) of the children had prenatal exposure to cannabis and 12% (n = 10) had postnatal exposure to cannabis, with two children experiencing this exposure at both time points. The most common cannabinoid detected in pregnancy was Δ9-THC, whereas the most common cannabinoid detected in childhood was CBD. Postnatal exposure to cannabis was associated with more aggressive behavior (β: 3.2; 95% CI: 0.5, 5.9), attention deficit/hyperactivity problems (β: 8.0; 95% CI: 2.2, 13.7), and oppositional/defiant behaviors (β: 3.2; 95% CI: 0.2, 6.3), as well as less cognitive flexibility (β: −15.6; 95% CI: −30.0, −1.2) and weaker receptive language (β: −9.7; 95% CI: −19.2, −0.3). By contrast, prenatal exposure to cannabis was associated with fewer internalizing behaviors (mean difference: −10.2; 95% CI: −20.3, −0.2) and fewer somatic complaints (mean difference: −5.2, 95% CI: −9.8, −0.6). Conclusions: Our study suggests that postnatal exposure to cannabis is associated with more behavioral and cognitive problems among 5-year-old children, independent of prenatal and postnatal exposure to tobacco. The potential risks of cannabis use (including smoking and vaping) during pregnancy and around young children should be more widely communicated to parents.
Effect of Humus on the Solidification and Stabilization of Heavy Metal Contaminated River Sediment
Authors: Gao Huimin , Tao Hong , Yang Yang , Che Qingyang , Tang Qinyi , Gu Yong
Published: March 2023

To better reutilize heavy metal contaminated river sediment containing organic matter, the sediments in a river located in Chongming District, Shanghai were collected and Portland cement was used as a curing agent along with commercial organic matter to conduct the solidification/stabilization experiment. The unconfined compressive strength and heavy metal leaching concentrations of solidified blocks with different water content, organic matter content, and cement content were tested and analyzed to determine the optimal ratio. The effects of fulvic acid (FA), humic acid (HA), and an HA/FA ratio on the solidification and stabilization, as well as the speciation of heavy metals in sediment before and after solidification and stabilization, were studied. The results showed that when the organic content of the sediment is 6.16%, the water content is 65% and the cement content is greater than 38%, so the curing effect proves to be satisfactory. Fulvic acid has a stronger inhibiting effect on cement hydration than humic acid, and its consumption in the curing process is more significant. The addition of humic acid contributes to the stabilization of heavy metals, while the increase in fulvic acid greatly weakens the stability of heavy metals. The exchangeable state of heavy metals in the sediment has been reduced to varying degrees after solidification and stabilization. The research results can provide a basis for the reclamation and utilization of heavy metal contaminated river sediment with organic matter.
The State of Artificial Intelligence in Nursing Education: Past, Present, and Future Directions
Authors: De Gagne Jennie C.
Published: March 2023

As health care continues to evolve and become increasingly complex, nursing education must also evolve to keep pace with the changing landscape [...]
Paternal Experiences of Perinatal Loss—A Scoping Review
Authors: Mota Cecilia , Sánchez Claudia , Carreño Jorge , Gómez María Eugenia
Published: March 2023

Background: Perinatal grief is one of the most complex and devastating types of mourning for both mothers and fathers; however, there is still little research on the psychological impact on men who experience it. Therefore, the objective of this study was to summarize and synthetize the existing literature on the way men’s grief is experienced. Methods: A search was carried out to examine three databases for articles published in the last four years; 56 articles were obtained, and 12 were retained for analysis. Results: Four common themes were found: the men’s experience of grief, their role as fathers, the impact of the death, and their needs regarding grief and how to face it. Conclusions: There is also a need for discussion of the importance of validating perinatal grief in men and studies that examine it without social gender stigmas in order to provide them with effective emotional support.
COVID-19 Public Health Measures and Patient and Public Involvement in Health and Social Care Research: An Umbrella Review
Authors: Fouladi Negin , Tchangalova Nedelina , Ajayi Damilola , Millwee Elizabeth , Lovett Corinne , Del Sordi Alana , Liggett Samantha , De Silva Malki , Bonilla Laura , Nkwonta Angel , Ramnarine Leah , Munoz Allyssa , Frazer Kate , Kroll Thilo
Published: March 2023

An umbrella review of previously published systematic reviews was conducted to determine the nature and extent of the patient and public involvement (PPI) in COVID-19 health and social care research and identify how PPI has been used to develop public health measures (PHM). In recent years, there has been a growing emphasis on PPI in research as it offers alternative perspectives and insight into the needs of healthcare users to improve the quality and relevance of research. In January 2022, nine databases were searched from 2020–2022, and records were filtered to identify peer-reviewed articles published in English. From a total of 1437 unique records, 54 full-text articles were initially evaluated, and six articles met the inclusion criteria. The included studies suggest that PHM should be attuned to communities within a sociocultural context. Based on the evidence included, it is evident that PPI in COVID-19-related research is varied. The existing evidence includes written feedback, conversations with stakeholders, and working groups/task forces. An inconsistent evidence base exists in the application and use of PPI in PHM. Successful mitigation efforts must be community specific while making PPI an integral component of shared decision-making.
Should We Use the Men Load–Velocity Profile for Women in Deadlift and Hip Thrust?
Authors: Nieto-Acevedo Raúl , Romero-Moraleda Blanca , Montalvo-Pérez Almudena , Valdés-Álvarez Agustín , García-Sánchez Carlos , Mon-López Daniel
Published: March 2023

Injuries are common in team sports and can impact both team and individual performance. In particular, hamstring strain injuries are some of the most common injuries. Furthermore, hamstring injury ratios, in number of injuries and total absence days, have doubled in the last 21 seasons in professional soccer. Weakness in hip extensor strength has been identified as a risk factor in elite-level sprinters. In addition, strength imbalances of the hamstring muscle group seem to be a common cause of hamstring strain injuries. In this regard, velocity-based training has been proposed to analyze deficits in the force–velocity profile. Previous studies have shown differences between men and women, since there are biomechanical and neuromuscular differences in the lower limbs between sexes. Therefore, the aim of this study was to compare the load–velocity profile between males and females during two of the most important hip extension exercises: the hip thrust and the deadlift. Sixteen men and sixteen women were measured in an incremental loading test following standard procedures for the hip thrust and deadlift exercises. Pearson’s correlation (r) was used to measure the strength of the correlation between movement velocity and load (%1RM). The differences in the load–velocity relationship between the men and the women were assessed using a 2 (sex) × 15 (load) repeated-measures ANOVA. The main findings revealed that: (I) the load–velocity relationship was always strong and linear in both exercises (R2 range: 0.88–0.94), (II) men showed higher velocities for light loads (30–50%1RM; effect size: 0.9–0.96) than women for the deadlift, but no significant differences were found for the hip thrust. Based on the results of this study, the load–velocity equations seem to be sex-specific. Therefore, we suggest that using sex-specific equations to analyze deficits in the force–velocity profile would be more effective to control intensity in the deadlift exercise.
Development and Validation of Nutrition and Food Safety Educational Material for Fish Processors in Nigeria
Authors: Adegoye Grace Adeola , Tolar-Peterson Terezie , Ene-Obong Henrietta Nkechi , Nuntah Joseph Nkem , Pasqualino Monica M. , Mathews Rahel , Silva Juan L. , Cheng Wen-Hsing , Evans Marion Willard , Pincus Lauren
Published: March 2023

Introduction: fish can be an affordable and accessible animal-source food in many Low- and Middle-Income Countries (LMIC). Background: Traditional fish processing methods pose a risk of exposing fish to various contaminants that may reduce their nutritional benefit. In addition, a lack of literacy may increase women fish processors’ vulnerability to malnutrition and foodborne diseases. Objective: The overall aim of the project was to educate women and youth fish processors in Delta State, Nigeria about the benefit of fish in the human diet and to develop low literacy tools to help them better market their products. The objective of this study was to describe the development and validation of a low-literacy flipbook designed to teach women fish processors about nutrition and food safety. Method: developing and validating instructional material requires understanding the population, high-quality and relevant graphics, and the involvement of relevant experts to conduct the content validation using the Content Validity Index (CVI) and the index value translated with the Modified Kappa Index (k). Result: The Item-level Content Validity Index (I-CVI) value of all domains evaluated at the initial stage was 0.83 and the Scale-level Content Validity Index (S-CVI) was 0.90. At the final stage, the material was validated with CVI 0.983 by four experts and satisfied the expected minimum CVI value for this study (CVI ≥ 0.83, p-value = 0.05). The overall evaluation of the newly developed and validated flipbook was “excellent”. Conclusions: the developed material was found to be appropriate for training fish processors in Nigeria in nutrition and food safety and could be modified for a population of fish processors in other LMICs.
Are We Facing a Radical Change in the Migration Behavior of Medical Graduates from Less Developed Countries? Demographic Profile vs. Social Push Factors
Authors: Vasile Valentina , Bunduchi Elena , Stefan Daniel , Comes Calin-Adrian , Vasile Razvan , Stefan Anamari-Beatrice
Published: March 2023

The phenomenon of migration among medical personnel from less developed countries is a large one, with negative effects on the origin country, but more worrying is graduates’ propensity to migrate during or immediately after university studies. The analysis of the labor market in the health sector from the last two decades shows us greater attractiveness of employment in (more) economically developed states compared to the demand from the health sector in graduates’ origin countries. This research’s purpose is to identify the determinants of the propensity to study and work abroad of medical students as a defined factor for better employment, and to identify the push factors in the origin country. As a result of the dichotomous nature of the dependent variables, logistic regression was applied. The independent variables (gender, residence, medical specialization, grades and perceived economic status) were used to identify the odds of the intention to migrate for studies. The results highlighted a higher propensity to migrate for studies among medical students, with opportunities offered by universities differing across countries and geographical areas. Moreover, students with a lower level of household income have openness to migrate, the tuition fees being managed through part-time/temporary employment during studies.
Identification of Emerging Roadkill Hotspots on Korean Expressways Using Space–Time Cubes
Authors: Kim Minkyung , Lee Sangdon
Published: March 2023

Collisions with wild animals on high-speed expressways not only lead to roadkill but can also cause accidents that incur considerable human and economic costs. Based on roadkill data from 2004–2019 for four common wildlife species involved in collisions with vehicles on expressways in Korea (water deer, common raccoon dog, Korean hare, and wild boar), the present study conducted optimized hotspot analysis and identified spatiotemporal patterns using a space–time cube (STC) approach. Temporal and spatial differences in the roadkill data were observed between species. Water deer were the most common roadkill species of the four studied, with hotspots in the southern region of the capital area, in the Chungnam region, and in the western Chungbuk and Gangwon-do regions. However, the instances of water deer roadkill over time differed between each region. In addition, it was found that the number of cases of wild boar roadkill has increased recently. In particular, a number of new hotspot areas were observed centered on the metropolitan area Gyeonggi-do, which contains a high population and significant infrastructure. Overall, the emerging hotspot analysis based on STCs was able to determine cold spot and hotspot trends over time, allowing for a more intuitive understanding of spatiotemporal clustering patterns and associated changes than cumulative density-oriented hotspot analysis. As a result, it becomes easier to analyze the causes of roadkill and to establish reduction measures according to priority.
Development of a Proposal for a Program to Promote Positive Mental Health Literacy among Adolescents: A Focus Group Study
Authors: Nobre Joana , Arco Helena , Monteiro Francisco , Oliveira Ana Paula , Ferré-Grau Carme , Sequeira Carlos
Published: March 2023

Over the last years, there have been several studies that have shown insufficient levels of adolescents’ mental health literacy (MHL). Knowledge about intervention programs that promote positive mental health literacy (PMeHL) among adolescents is still very scarce. In this sense, we defined as objectives to identify and describe the necessary components to design a program proposal that promotes adolescents’ PMeHL. We conducted an exploratory, descriptive, qualitative study using two focus groups in July and September 2022 with an intentional non-probability sample of eleven participants (nine professional experts and two adolescents). Data were analyzed using content analysis, using NVivo® 12 software (version 12, QRS International: Daresbury Cheshire, UK). We obtained a total of four categories and eighteen subcategories: structure (context; format; contents; length and frequency; pedagogical methods; pedagogical techniques; resources; denomination), participants (target group; program facilitators), assessment (timing; evaluation instruments), other components (planning, articulation and adaptation; involvement; training; special situations; partnerships; referral). The perspectives of the professional experts and of the adolescents that we obtained from this study contributed to the design of a proposal for a program to promote adolescents’ PMeHL.
Inter- vs. Intra-Molecular Hydrogen Bond in Complexes of Nitrophthalic Acids with Pyridine
Authors: Jóźwiak Kinga , Jezierska Aneta , Panek Jarosław J. , Kochel Andrzej , Filarowski Aleksander
Published: March 2023

This study covers the analysis of isomeric forms of nitrophthalic acids with pyridine. This work dwells on the complementary experimental (X-ray, IR and Raman) and theoretical (Car-Parrinello Molecular Dynamics (CPMD) and Density Functional Theory (DFT)) studies of the obtained complexes. The conducted studies showed that steric repulsion between the nitro group in ortho-position and the carboxyl group causes significant isomeric changes. Modeling of the nitrophthalic acid—pyridine complex yielded a short strong intramolecular hydrogen bond (SSHB). The transition energy from the isomeric form with an intermolecular hydrogen bond to the isomeric form with an intramolecular hydrogen bond was estimated.
Recognizing Minor Leukemic Populations with Monocytic Features in Mixed-Phenotype Acute Leukemia by Flow Cell Sorting Followed by Cytogenetic and Molecular Studies: Report of Five Exemplary Cases
Authors: Semchenkova Alexandra , Zerkalenkova Elena , Demina Irina , Kashpor Svetlana , Volchkov Egor , Zakharova Elena , Larin Sergey , Olshanskaya Yulia , Novichkova Galina , Maschan Alexey , Maschan Michael , Popov Alexander
Published: March 2023

Mixed-phenotype acute leukemia (MPAL), a rare and heterogeneous category of acute leukemia, is characterized by cross-lineage antigen expression. Leukemic blasts in MPAL can be represented either by one population with multiple markers of different lineages or by several single-lineage populations. In some cases, a major blast population may coexist with a smaller population that has minor immunophenotypic abnormalities and may be missed even by an experienced pathologist. To avoid misdiagnosis, we suggest sorting doubtful populations and leukemic blasts and searching for similar genetic aberrations. Using this approach, we examined questionable monocytic populations in five patients with dominant leukemic populations of B-lymphoblastic origin. Cell populations were isolated either for fluorescence in situ hybridization or for clonality assessment by multiplex PCR or next-generation sequencing. In all cases, monocytic cells shared the same gene rearrangements with dominant leukemic populations, unequivocally confirming the same leukemic origin. This approach is able to identify implicit cases of MPAL and therefore leads to the necessary clinical management for patients.
Biomarkers for Early Detection of Cancer: Molecular Aspects
Authors: Tappia Paramjit S. , Ramjiawan Bram
Published: March 2023

According to the World Health Organization, cancer is a leading cause of death worldwide, representing almost 10 million deaths in 2020 [...]
KDM5D Histone Demethylase Identifies Platinum-Tolerant Head and Neck Cancer Cells Vulnerable to Mitotic Catastrophe
Authors: Chen Tsung-Ming , Huang Chih-Ming , Setiawan Syahru Agung , Hsieh Ming-Shou , Sheen Chih-Chi , Yeh Chi-Tai
Published: March 2023

Head and neck squamous cell carcinoma (HNSCC) is a major contributor to cancer incidence globally and is currently managed by surgical resection followed by adjuvant chemoradiotherapy. However, local recurrence is the major cause of mortality, indicating the emergence of drug-tolerant persister cells. A specific histone demethylase, namely lysine-specific demethylase 5D (KDM5D), is overexpressed in diverse types of cancers and involved in cancer cell cycle regulation. However, the role of KDM5D in the development of cisplatin-tolerant persister cells remains unexplored. Here, we demonstrated that KDM5D contributes to the development of persister cells. Aurora Kinase B (AURKB) disruption affected the vulnerability of persister cells in a mitotic catastrophe–dependent manner. Comprehensive in silico, in vitro, and in vivo experiments were performed. KDM5D expression was upregulated in HNSCC tumor cells, cancer stem cells, and cisplatin-resistant cells with biologically distinct signaling alterations. In an HNSCC cohort, high KDM5D expression was associated with a poor response to platinum treatment and early disease recurrence. KDM5D knockdown reduced the tolerance of persister cells to platinum agents and caused marked cell cycle deregulation, including the loss of DNA damage prevention, and abnormal mitosis-enhanced cell cycle arrest. By modulating mRNA levels of AURKB, KDM5D promoted the generation of platinum-tolerant persister cells in vitro, leading to the identification of the KDM5D/AURKB axis, which regulates cancer stemness and drug tolerance of HNSCC. Treatment with an AURKB inhibitor, namely barasertib, resulted in a lethal consequence of mitotic catastrophe in HNSCC persister cells. The cotreatment of cisplatin and barasertib suppressed tumor growth in the tumor mouse model. Thus, KDM5D might be involved in the development of persister cells, and AURKB disruption can overcome tolerance to platinum treatment in HNSCC.
SARS-CoV-2 Spike Protein and Neutralizing Anti-Spike Protein Antibodies Modulate Blood Platelet Function
Authors: Luzak Boguslawa , Rozalski Marcin , Przygodzki Tomasz , Boncler Magdalena , Wojkowska Dagmara , Kosmalski Marcin , Watala Cezary
Published: March 2023

Several studies report elevated blood platelet activation and altered platelet count in COVID-19 patients, but the role of the SARS-CoV-2 spike protein in this process remains intriguing. Additionally, there is no data that anti-SARS-CoV-2 neutralizing antibodies (nAb) may attenuate spike protein activity toward blood platelets. Our results indicate that under in vitro conditions, the spike protein increased the collagen-stimulated aggregation of isolated platelets and induced the binding of vWF to platelets in ristocetin-treated blood. The spike protein also significantly reduced collagen- or ADP-induced aggregation or decreased GPIIbIIIa (fibrinogen receptor) activation in whole blood, depending on the presence of the anti-spike protein nAb. Our findings suggest that studies on platelet activation/reactivity in COVID-19 patients or in donors vaccinated with anti-SARS-CoV-2 and/or previously-infected COVID-19 should be supported by measurements of spike protein and IgG anti-spike protein antibody concentrations in blood.
Diabetes during Pregnancy: A Transgenerational Challenge
Authors: Giannubilo Stefano R. , Ciavattini Andrea
Published: March 2023

For many years, gestational diabetes mellitus (GDM) has been defined as “a glucose intolerance of variable magnitude that begins or is first diagnosed in pregnancy” and that, in most cases, resolves after delivery [...]
Relationship between Lower Extremity Peripheral Arterial Disease and Mild Cognitive Impairment in Hemodialysis Patients
Authors: Nishimura Akinori , Hidaka Sumi , Kawaguchi Takayuki , Watanabe Aki , Mochida Yasuhiro , Ishioka Kunihiro , Mwanatanbwe Milanga , Ohtake Takayasu , Kobayashi Shuzo
Published: March 2023

Background: The link between arterial stiffness and mild cognitive impairment (MCI) in patients on hemodialysis (HD) has been receiving increased attention. The purpose of this study was to investigate the relationship between cognitive function and ankle brachial index (ABI) and toe brachial index (TBI) values in patients on hemodialysis. Of the 100 participants (mean age: 67.9 years; average history of hemodialysis: 7.3 years). Of these, 46.0% had MCI. The MoCA-J scores were significantly higher in the ABI ≥ 1.06 group. However, the MoCA-J scores divided into the two groups according to the TBI cutoff value were not significantly different. In a multiple regression model with the MoCA-J scores as the objective variable, the ABI was a significantly associated factor. This study indicates that a low ABI might be associated with MCI.
Physiotherapy and Exercise Management of People Undergoing Surgery for Lung Cancer: A Survey of Current Practice across Australia and New Zealand
Authors: Whish-Wilson Georgina A. , Edbrooke Lara , Cavalheri Vinicius , Denehy Linda , Seller Daniel , Granger Catherine L. , Parry Selina M.
Published: March 2023

Background: Moderate- to high-certainty evidence supports the benefits of pre- and post-operative exercise for people undergoing surgical resection for lung cancer. Despite this, exercise programs are not commonly provided. Previous data regarding exercise practices are a decade old. Therefore, this study aimed to understand current exercise practices in surgical lung cancer care in Australia and New Zealand. Methods: An online cross-sectional survey of Australian and New Zealand allied health professionals specialising in exercise-based interventions was carried out. Survey development and reporting adhered to CHERRIES and CROSS checklists. Institutions with thoracic surgery departments were invited to participate via email, and additional responses were sought via snowballing. Results: The response rate was 81%, with a total of 70 health services responding. A total of 18 (26%) pre-operative services, 59 (84%) inpatient post-operative services, and 39 (55%) community/outpatient post-operative services were identified. Only eight (11%) services provided a pre-operative exercise program. Half of the respondents referred less than 25% of patients to community/outpatient exercise programs on hospital discharge. Respondents reported that their clinical management was predominantly influenced by established workplace practices and personal experience rather than evidence. Conclusions: The availability and uptake of pre- and post-operative exercise remain low, and work should continue to make pre/post-operative exercise training usual practice.
Effect of Traditional Chinese Exercises on Patients with Chronic Heart Failure (TCE-HF): A Systematic Review and Meta-Analysis
Authors: Bao Qinyi , Lei Shuxin , Guo Shitian , Wang Zhuo , Yu Jiaye , You Yayu , Zhang Ning , Xie Xiaojie
Published: March 2023

Exercise-based cardiac rehabilitation is safe and effective for chronic heart failure (CHF) patients. The present study aimed to investigate the effects of traditional Chinese exercise (TCE) on patients with CHF and the impact of exercise types and duration. Evaluation of randomized controlled trials (RCTs) of TCE in patients with CHF published since 1997 from PubMed, Embase, Web of Science, the Cochrane Library, Chongqing VIP, Wanfang Databases, and the China National Knowledge was performed. A total of 41 RCTs, including 3209 patients with CHF, were included. It showed that TCE significantly increased 6-min walk distance (6MWD) [mean difference (MD) = 72.82 m, p < 0.001] and left ventricular ejection fraction (MD = 5.09%, p < 0.001), whereas reduced B-type natriuretic peptide (BNP) (MD = −56.80 pg/mL, p < 0.001), N-terminal pro-BNP (MD = −174.94 pg/mL, p < 0.05), and Minnesota Living with Heart Failure Questionnaire scores (MD = −11.31, p < 0.001). However, no significant difference was found in the effects of TCE on peak oxygen consumption. The increase in TCE weekly duration and program duration significantly improved 6MWD (MD = 71.91 m, p < 0.001; MD = 74.11 m, p < 0.001). The combination of TCE and conventional aerobic exercise significantly improved 6MWD (MD = 19.86 m, p < 0.005). TCE improves exercise capacity, cardiac function, and quality of life in patients with CHF, which might be an optimal and available pattern of exercise-based cardiac rehabilitation.
Chemotherapy Response Score in Ovarian Cancer Patients: An Overview of Its Clinical Utility
Authors: Rodolakis Ioannis , Pergialiotis Vasilios , Liontos Michalis , Haidopoulos Dimitrios , Loutradis Dimitrios , Rodolakis Alexandros , Bamias Aristotelis , Thomakos Nikolaos
Published: March 2023

The chemotherapy response score has been developed over the last few years as a predictive index of survival outcomes for patients with advanced-stage epithelial ovarian cancer undergoing interval debulking surgery. While its importance in predicting patients at risk of developing recurrences earlier seems to be important, its accuracy in determining patients with a shorter overall survival remains arbitrary. Moreover, standardization of the actual scoring system that was initially developed as a 6-tiered score and adopted as a 3-tiered score is still needed, as several studies suggest that a 2-tiered system is preferable. Given its actual importance in detecting patients with shorter progression-free survival, research should also focus on the actual predictive value of determining patients with platinum resistance, as a suboptimal patient response to standard neoadjuvant chemotherapy might help determine patients at risk of an earlier recurrence. In the present review, we summarize current knowledge retrieved from studies addressing outcomes related to the chemotherapy response score in epithelial ovarian cancer patients undergoing neoadjuvant chemotherapy and discuss differences in outcome reporting to help provide directions for further research.
A Mathematical Approach for Sound Insulation Characteristics and Cost Optimization of Double-Layer Composite Structures
Authors: Zhang Liang , Zhang Huawei , Chen Qiyu , Long Danfeng
Published: March 2023

The compressor is the primary source of noise in a refrigeration system. Most compressors are wrapped with multi-layer sound insulation cotton for noise reduction and sound insulation. We explore the sound insulation law of different polyvinyl chloride thicknesses and non-woven fibers. Polyvinyl chloride with varying thicknesses and non-woven fibers are then combined by bonding to study the sound insulation characteristics of a two-layer composite structure. A sound insulation prediction model is established using the multi-parameter nonlinear regression method. An optimal cost mathematical model is established based on experimental and mathematical methods that can quickly determine the optimal cost scheme for different designs with the same effect.
An Innovative Approach of Surface Polishing for SRF Cavity Applications
Authors: Hryhorenko Oleksandr , Antoine Claire Z. , Magnin William , Rajkumar Monish , Brisset François , Guilet Stephane , Longuevergne David
Published: March 2023

The damage layer produced during the Niobium sheets and cavity fabrication processes is one of the main reasons why cavities have to undergo an extensive surface preparation process to recover optimal superconducting properties. Today, this includes the use of lengthy, costly, and dangerous conventional polishing techniques as buffered chemical polishing (BCP), or electro-polishing (EP). We propose to avoid or at least significantly reduce the use of acids. We developed a novel method based on metallographic polishing of Nb sheets, consisting of 2–3 steps. We demonstrate that this surface processing procedure could be transferred to large dimensions and an industrialized scale thanks to the limited number of steps and its compatibility with standard lapping polishing devices.