bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure 7 from Targeting the EWSR1-FLI1 Oncogene-Induced Protein Kinase PKC-β Abolishes Ewing Sarcoma Growth
Authors: Surdez Didier , Benetkiewicz Magdalena , Perrin Virginie , Han Zhi-Yan , Pierron Gaëlle , Ballet Stelly , Lamoureux François , Rédini Françoise , Decouvelaere Anne-Valérie , Daudigeos-Dubus Estelle , Geoerger Birgit , de Pinieux Gonzague , Delattre Olivier , Tirode Franck
Published: March 2023

PDF file - 66K, Combined effect of TNFa with Enzastaurin on Ewing cell growth
Supplementary Figure 6 from Targeting the EWSR1-FLI1 Oncogene-Induced Protein Kinase PKC-β Abolishes Ewing Sarcoma Growth
Authors: Surdez Didier , Benetkiewicz Magdalena , Perrin Virginie , Han Zhi-Yan , Pierron Gaëlle , Ballet Stelly , Lamoureux François , Rédini Françoise , Decouvelaere Anne-Valérie , Daudigeos-Dubus Estelle , Geoerger Birgit , de Pinieux Gonzague , Delattre Olivier , Tirode Franck
Published: March 2023

PDF file - 102K, EWSR1-FLI1 expression upon Enzastaurin treatment
Supplementary Table 2 from Novel Transcriptional Targets of the SRY-HMG Box Transcription Factor SOX4 Link Its Expression to the Development of Small Cell Lung Cancer
Authors: Castillo Sandra D. , Matheu Ander , Mariani Niccolo , Carretero Julian , Lopez-Rios Fernando , Lovell-Badge Robin , Sanchez-Cespedes Montse
Published: March 2023

PDF file - 38K
Supplementary Figure 1 from Targeting the EWSR1-FLI1 Oncogene-Induced Protein Kinase PKC-β Abolishes Ewing Sarcoma Growth
Authors: Surdez Didier , Benetkiewicz Magdalena , Perrin Virginie , Han Zhi-Yan , Pierron Gaëlle , Ballet Stelly , Lamoureux François , Rédini Françoise , Decouvelaere Anne-Valérie , Daudigeos-Dubus Estelle , Geoerger Birgit , de Pinieux Gonzague , Delattre Olivier , Tirode Franck
Published: March 2023

PDF file - 122K, PRKC isoforms expression
Supplementary Figure 6 from Induction of the Stem-like Cell Regulator CD44 by Rho Kinase Inhibition Contributes to the Maintenance of Colon Cancer–Initiating Cells
Authors: Ohata Hirokazu , Ishiguro Tatsuya , Aihara Yuki , Sato Ai , Sakai Hiroaki , Sekine Shigeki , Taniguchi Hirokazu , Akasu Takayuki , Fujita Shin , Nakagama Hitoshi , Okamoto Koji
Published: March 2023

PDF file - 305K, CD44-/low cells are capable of forming CD44-positive tumors in mice
Supplementary Figure 4 from Induction of the Stem-like Cell Regulator CD44 by Rho Kinase Inhibition Contributes to the Maintenance of Colon Cancer–Initiating Cells
Authors: Ohata Hirokazu , Ishiguro Tatsuya , Aihara Yuki , Sato Ai , Sakai Hiroaki , Sekine Shigeki , Taniguchi Hirokazu , Akasu Takayuki , Fujita Shin , Nakagama Hitoshi , Okamoto Koji
Published: March 2023

PDF file - 85K, Inhibition of CD44 suppresses spheroid formation
Supplementary Figure 3 from Induction of the Stem-like Cell Regulator CD44 by Rho Kinase Inhibition Contributes to the Maintenance of Colon Cancer–Initiating Cells
Authors: Ohata Hirokazu , Ishiguro Tatsuya , Aihara Yuki , Sato Ai , Sakai Hiroaki , Sekine Shigeki , Taniguchi Hirokazu , Akasu Takayuki , Fujita Shin , Nakagama Hitoshi , Okamoto Koji
Published: March 2023

PDF file - 114K, CD44high cells in the spheroids show characteristics of cancer stem cells
Supplementary Figure 2 from Induction of the Stem-like Cell Regulator CD44 by Rho Kinase Inhibition Contributes to the Maintenance of Colon Cancer–Initiating Cells
Authors: Ohata Hirokazu , Ishiguro Tatsuya , Aihara Yuki , Sato Ai , Sakai Hiroaki , Sekine Shigeki , Taniguchi Hirokazu , Akasu Takayuki , Fujita Shin , Nakagama Hitoshi , Okamoto Koji
Published: March 2023

PDF file - 311K, The spheroids formed in the presence of ROCK inhibitor express colon cancer stem cell markers, differentiate into epithelial-like cells, and are capable of forming tumors in mice
Supplementary Table 1 from CD44s Regulates the TGF-β–Mediated Mesenchymal Phenotype and Is Associated with Poor Prognosis in Patients with Hepatocellular Carcinoma
Authors: Mima Kosuke , Okabe Hirohisa , Ishimoto Takatsugu , Hayashi Hiromitsu , Nakagawa Shigeki , Kuroki Hideyuki , Watanabe Masayuki , Beppu Toru , Tamada Mayumi , Nagano Osamu , Saya Hideyuki , Baba Hideo
Published: March 2023

PDF file - 107K, Correlation between a CD44shigh/vimentinhigh/E-cadherinlow expression profile and the clinicopathological factors of HCC patients
Supplementary Figure 5 from Candidate Pathways for Promoting Differentiation or Quiescence of Oligodendrocyte Progenitor-like Cells in Glioma
Authors: Dougherty Joseph D. , Fomchenko Elena I. , Akuffo Afua A. , Schmidt Eric , Helmy Karim Y. , Bazzoli Elena , Brennan Cameron W. , Holland Eric C. , Milosevic Ana
Published: March 2023

PDF file - 506K, Differentiation or Quiescence candidates show similar expression patterns in mouse and human glioma. A: Scatterplot of whole tumor (not TRAP) microarray data (x-axis), compared to normal mouse cortex (y-axis), shows strong enrichment of most OPC genes (blue), except the for DorQ candidates, which show only modest enrichment (purple). For comparison, there is no enrichment of mature oligodendrocyte gene (green). Up to 50 genes shown per class. B: Scatterplot of human proneural tumor microarray data from TCGA (x-axis), compared to normal human brain (y-axis), shows strong enrichment of most OPC genes (blue), and only modest enrichment of DorQ candidates (purple). For comparison, there is no enrichment of mature oligodendrocyte gene (green). C: Scatterplot of log2 fold changes for candidates, OPC and mature oligodendrocyte genes, in human (y-axis) and mouse tumor vs. normal comparisons shows good cross species correlation of gene expression patterns (myelinating oligodendrocytes, red, .44, DORQ candidates, purple, .49, OPC, blue, .62. Pearsons correlations). D: Candidate genes are less enriched then other OPC genes in both human (p<.05), and mouse (p < 1E-6, Welch's T-Test). Myelinating oligodendrocyte genes are shown for comparison
Supplementary Figure 3 from Candidate Pathways for Promoting Differentiation or Quiescence of Oligodendrocyte Progenitor-like Cells in Glioma
Authors: Dougherty Joseph D. , Fomchenko Elena I. , Akuffo Afua A. , Schmidt Eric , Helmy Karim Y. , Bazzoli Elena , Brennan Cameron W. , Holland Eric C. , Milosevic Ana
Published: March 2023

PDF file - 391K, Gene Ontology analysis reveals that RNAs specific to OPCs (such as in black box, from Figure 2E), are highly enriched in messages related to cell cycle, as expected, as well as in genes involved in biopolymer modification
Supplementary Methods from Histone Deacetylase Inhibitors Influence Chemotherapy Transport by Modulating Expression and Trafficking of a Common Polymorphic Variant of the ABCG2 Efflux Transporter
Authors: Basseville Agnes , Tamaki Akina , Ierano Caterina , Trostel Shana , Ward Yvona , Robey Robert W. , Hegde Ramanujan S. , Bates Susan E.
Published: March 2023

PDF file - 65K
Supplementary Figure 4 from Histone Deacetylase Inhibitors Influence Chemotherapy Transport by Modulating Expression and Trafficking of a Common Polymorphic Variant of the ABCG2 Efflux Transporter
Authors: Basseville Agnes , Tamaki Akina , Ierano Caterina , Trostel Shana , Ward Yvona , Robey Robert W. , Hegde Ramanujan S. , Bates Susan E.
Published: March 2023

PDF file - 26K, CHX does not affect histone and �-tubulin acetylation induced by HDIs
Supplementary Figures 1-10 from Cancer Cell Secretion of the DAMP Protein HMGB1 Supports Progression in Malignant Mesothelioma
Authors: Jube Sandro , Rivera Zeyana S. , Bianchi Marco E. , Powers Amy , Wang Ena , Pagano Ian , Pass Harvey I. , Gaudino Giovanni , Carbone Michele , Yang Haining
Published: March 2023

PDF file - 4.5MB, Figure S1. HMGB1 inhibitors hinder asbestos-induced HM transformation. Figure S2. Expressions of the HMGB1 receptors TLR2 and TLR4 are variable in MM cells. Figure S3. HMGB1 is a chemotactic and mitogenic factor in MM cells. Figure S4. Secreted HMGB1 is an autocrine chemotactic factor in MM cells. Figure S5. HMGB1 inhibition has no effect on the survival and migration of MM cells that are low HMGB1 producers (PPM-Mill). Figure S6. HMGB1 inhibition does not induce cell death in HM. Figure S7. Inhibition of HMGB1 induces apoptosis in MM cells "addicted" to HMGB1. Figure S8. HMGB1 supports the invasive phenotype in MM cells. Figure S9. Gene expression analysis of REN cells treated with HMGB1.
Supplementary Figures 1-8 from MEK Inhibition Leads to PI3K/AKT Activation by Relieving a Negative Feedback on ERBB Receptors
Authors: Turke Alexa B. , Song Youngchul , Costa Carlotta , Cook Rebecca , Arteaga Carlos L. , Asara John M. , Engelman Jeffrey A.
Published: March 2023

PDF file - 515K, Supplemenal figures 1-8 support the main figures in the manuscript, and include characterization of compounds and target inhibition, quantification of ERBB3 mRNA and HRG ligand, cell line characterization, and data supporting mass spectrometry experiments.
Supplementary Figure 6 from Dysfunction of Nucleus Accumbens-1 Activates Cellular Senescence and Inhibits Tumor Cell Proliferation and Oncogenesis
Authors: Zhang Yi , Cheng Yan , Ren Xingcong , Hori Tsukasa , Huber-Keener Kathryn J. , Zhang Li , Yap Kai Lee , Liu David , Shantz Lisa , Qin Zheng-Hong , Zhang Suping , Wang Jianrong , Wang Hong-Gang , Shih Ie-Ming , Yang Jin-Ming
Published: March 2023

PDF file - 98K, Generation of NAC1 knockout mice
Supplementary Figure 1 from LIGHT Delivery to Tumors by Mesenchymal Stem Cells Mobilizes an Effective Antitumor Immune Response
Authors: Zou Weibin , Zheng Huilin , He Tong-Chuan , Chang Jinjia , Fu Yang-Xin , Fan Weimin
Published: March 2023

PDF file - 1.2MB, MSC-L mainly located in tumor tissues and could express LIGHT in tumor
Supplementary Figure 4 from Radiotherapy Increases the Permissiveness of Established Mammary Tumors to Rejection by Immunomodulatory Antibodies
Authors: Verbrugge Inge , Hagekyriakou Jim , Sharp Leslie L. , Galli Mara , West Alison , McLaughlin Nicole M. , Duret Hélène , Yagita Hideo , Johnstone Ricky W. , Smyth Mark J. , Haynes Nicole M.
Published: March 2023

PDF file - 55K, Side-by-side immunohistochemical analysis of the 4T1.2 (A) and AT-3 (B) tumor microenviroment
Supplementary Methods from Embryonic Protein Nodal Promotes Breast Cancer Vascularization
Authors: Quail Daniela F. , Walsh Logan A. , Zhang Guihua , Findlay Scott D. , Moreno Juan , Fung Laura , Ablack Amber , Lewis John D. , Done Susan J. , Hess David A. , Postovit Lynne-Marie
Published: March 2023

PDF file - 153K
Supplementary Table 1 from AZD4547: An Orally Bioavailable, Potent, and Selective Inhibitor of the Fibroblast Growth Factor Receptor Tyrosine Kinase Family
Authors: Gavine Paul R. , Mooney Lorraine , Kilgour Elaine , Thomas Andrew P. , Al-Kadhimi Katherine , Beck Sarah , Rooney Claire , Coleman Tanya , Baker Dawn , Mellor Martine J. , Brooks A. Nigel , Klinowska Teresa
Published: March 2023

PDF file - 52K
Supplementary Figure Legends 1-2 from AZD4547: An Orally Bioavailable, Potent, and Selective Inhibitor of the Fibroblast Growth Factor Receptor Tyrosine Kinase Family
Authors: Gavine Paul R. , Mooney Lorraine , Kilgour Elaine , Thomas Andrew P. , Al-Kadhimi Katherine , Beck Sarah , Rooney Claire , Coleman Tanya , Baker Dawn , Mellor Martine J. , Brooks A. Nigel , Klinowska Teresa
Published: March 2023

PDF file - 59K
Supplementary Figures 1-9 from VEGF Exerts an Angiogenesis-Independent Function in Cancer Cells to Promote Their Malignant Progression
Authors: Cao Ying , E Guangqi , Wang Enfeng , Pal Krishnendu , Dutta Shamit K. , Bar-Sagi Dafna , Mukhopadhyay Debabrata
Published: March 2023

PDF file - 824K, 1) Supplementary Figure S1. VEGF knock down in RCC cells restricted the tumor size and induced a differentiation phenotype in vivo. 2) Supplementary Figure S2. VEGF knock down in RCC cells restricted the tumor phenotypes in vitro. 3) Supplementary Figure S3. VEGF knockdown did not affect 786-O and A-498 cell proliferation and apoptosis. 4) Supplementary Figure S4. Induction of VEGF shRNA ((+)Dox) reduced A-498 cells anchorage independent clonogenic ability. 5) Supplementary Figure S5. Low concentration (0.2ug/ml) Doxycycline did not have a significant effect on A-498 cell proliferation, apoptosis, differentiation, or tumor formation. 6) Supplementary Figure S6. Mouse xenograft model of VEGF in tumorigenesis using a GFP/RFP combination system. 7) Supplementary Figure S7. The distribution of GFP and RFP labeled cells and the vascular densities in the tumor tissue. 8) Supplementary Figure S8. ERK1/2 and AKT were activated by VEGF. 9) Supplementary Figure S9. Knockdown of SOS1/2 induced 786-O cells into a differentiation phenotype.
Supplementary Figure 4 from CCN6 Modulates BMP Signaling via the Smad-Independent TAK1/p38 Pathway, Acting to Suppress Metastasis of Breast Cancer
Authors: Pal Anupama , Huang Wei , Li Xin , Toy Kathy A. , Nikolovska-Coleska Zaneta , Kleer Celina G.
Published: March 2023

PDF file, 90K, Co-localization of CCN6 and BMP4 in clinical samples of breast cancer.
Supplementary Methods from ESE3/EHF Controls Epithelial Cell Differentiation and Its Loss Leads to Prostate Tumors with Mesenchymal and Stem-like Features
Authors: Albino Domenico , Longoni Nicole , Curti Laura , Mello-Grand Maurizia , Pinton Sandra , Civenni Gianluca , Thalmann George , D'Ambrosio Gioacchino , Sarti Manuela , Sessa Fausto , Chiorino Giovanna , Catapano Carlo V. , Carbone Giuseppina M.
Published: March 2023

PDF file - 105K
Supplementary Figures 1-8 from ESE3/EHF Controls Epithelial Cell Differentiation and Its Loss Leads to Prostate Tumors with Mesenchymal and Stem-like Features
Authors: Albino Domenico , Longoni Nicole , Curti Laura , Mello-Grand Maurizia , Pinton Sandra , Civenni Gianluca , Thalmann George , D'Ambrosio Gioacchino , Sarti Manuela , Sessa Fausto , Chiorino Giovanna , Catapano Carlo V. , Carbone Giuseppina M.
Published: March 2023

PDF file - 432K, Supplementary Figure 1 Histopathological and clinical parameters of primary prostate cancer patients in the two patient cohorts evaluated by TMAs. Supplementary Figure 2 ESE3/EHF knockdown induces epithelial to mesenchymal transition Supplementary Figure 3 Transient downregulation of ESE3/EHF induces a mesenchymal phenotype Supplementary Figure 4 In vivo formation of lung metastasis Supplementary Figure 5 Prostato-sphere formation by prostate epithelial cells Supplementary Figure 6 Transient downregulation of ESE3/EHF in PrECs and RWPE-1 cells induces stem-like properties Supplementary Figure 7 Prostato-sphere formation and stem-like properties in DU145 cells Supplementary Figure 8 Overall survival and PSA biochemical relapse in prostate cancer patients
Supplementary Materials and Methods from An NMR Metabolomics Approach for the Diagnosis of Leptomeningeal Carcinomatosis
Authors: Cho Hye Rim , Wen He , Ryu Young Jin , An Yong Jin , Kim Hyo Cheol , Moon Woo Kyung , Han Moon Hee , Park Sunghyouk , Choi Seung Hong
Published: March 2023

PDF file - 164K
Supplementary Figure 3 from Augmentation of Therapeutic Responses in Melanoma by Inhibition of IRAK-1,-4
Authors: Srivastava Ratika , Geng Degui , Liu Yingjia , Zheng Liqin , Li Zhaoyang , Joseph Mary Ann , McKenna Colleen , Bansal Navneeta , Ochoa Augusto , Davila Eduardo
Published: March 2023

PDF file - 49K, Role of TLR-induced cytokines and NF-kB on cell survival
Supplementary Figure 5 from Smac Mimetic LBW242 Sensitizes XIAP-Overexpressing Neuroblastoma Cells for TNF-α–Independent Apoptosis
Authors: Eschenburg Georg , Eggert Angelika , Schramm Alexander , Lode Holger N. , Hundsdoerfer Patrick
Published: March 2023

PDF file - 298K, Effect of LBW242 and etoposide treatment on TNF-� expression.
Supplementary Figures 1-11 from Distinct microRNA Expression Profiles in Prostate Cancer Stem/Progenitor Cells and Tumor-Suppressive Functions of let-7
Authors: Liu Can , Kelnar Kevin , Vlassov Alexander V. , Brown David , Wang Junchen , Tang Dean G.
Published: March 2023

PDF file - 1.5MB, Supplemental figures: microRNA expression profiling in prostate cancer stem/progenitor cell populations and biological and functional studies on selective miRNAs including let-7 and miR-301 in prostate cancer development
Supplementary Figure 2 from ARN-509: A Novel Antiandrogen for Prostate Cancer Treatment
Authors: Clegg Nicola J. , Wongvipat John , Joseph James D. , Tran Chris , Ouk Samedy , Dilhas Anna , Chen Yu , Grillot Kate , Bischoff Eric D. , Cai Ling , Aparicio Anna , Dorow Steven , Arora Vivek , Shao Gang , Qian Jing , Zhao Hong , Yang Guangbin , Cao Chunyan , Sensintaffar John , Wasielewska Teresa , Herbert Mark R. , Bonnefous Celine , Darimont Beatrice , Scher Howard I. , Smith-Jones Peter , Klang Mark , Smith Nicholas D. , De Stanchina Elisa , Wu Nian , Ouerfelli Ouathek , Rix Peter J. , Heyman Richard A. , Jung Michael E. , Sawyers Charles L. , Hager Jeffrey H.
Published: March 2023

PDF file - 241K
Supplementary Table 5 from Leptin and Soluble Leptin Receptor in Risk of Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition Cohort
Authors: Aleksandrova Krasimira , Boeing Heiner , Jenab Mazda , Bueno-de-Mesquita H. Bas , Jansen Eugene , van Duijnhoven Fränzel J. B. , Rinaldi Sabina , Fedirko Veronika , Romieu Isabelle , Riboli Elio , Gunter Marc J. , Westphal Sabine , Overvad Kim , Tjønneland Anne , Halkjær Jytte , Racine Antoine , Boutron-Ruault Marie-Christine , Clavel-Chapelon Françoise , Kaaks Rudolf , Lukanova Annekatrin , Trichopoulou Antonia , Lagiou Pagona , Trichopoulos Dimitrios , Mattiello Amalia , Pala Valeria , Palli Domenico , Tumino Rosario , Vineis Paolo , Buckland Genevieve , Sánchez María-José , Amiano Pilar , Huerta José María , Barricarte Aurelio , Menéndez Virginia , Peeters Petra H. , Söderberg Stefan , Palmqvist Richard , Allen Naomi E. , Crowe Francesca L. , Khaw Kay-Tee , Wareham Nickolas , Pischon Tobias
Published: March 2023

PDF file - 101K, Relative risks (RR-s) and 95% confidence intervals (CI-s) of colon, rectal and colorectal cancer according to sex-specific quintiles of baseline soluble leptin receptor (sOB-R) concentrations, in men and women, the European Prospective Investigation into Cancer and Nutrition (EPIC), 1992-2003
Supplementary Figures 1-9 from The MET Oncogene Is a Functional Marker of a Glioblastoma Stem Cell Subtype
Authors: De Bacco Francesca , Casanova Elena , Medico Enzo , Pellegatta Serena , Orzan Francesca , Albano Raffaella , Luraghi Paolo , Reato Gigliola , D'Ambrosio Antonio , Porrati Paola , Patanè Monica , Maderna Emanuela , Pollo Bianca , Comoglio Paolo M. , Finocchiaro Gaetano , Boccaccio Carla
Published: March 2023

PDF file - 2.3MB, Figure S1: Histopathology of primary glioblastomas and genetic lesions of neurospheres. Figure S2: Genome-wide expression profiling and unsupervised hierarchical clustering of neurospheres (classical, mesenchymal and proneural centroids). Figure S3: Expression of MET, EGFR, and a panel of self-renewal markers in neurospheres. Figure S4: Genome-wide expression profiling and unsupervised hierarchical clustering of neurospheres (multiple signatures). Figure S5: Proliferative response, activation of tyrosine kinase receptors, and differentiation pattern in Met-neg-NS and Met-pos-NS. Figure S6: Methigh and Metneg sorting parameters. Figure S7: The Methigh subpopulation of Met-pos-NS retains clonogenic and tumorigenic cells. Figure S8: H&E and Met immunohistochemical staining of histological sections from tumors formed by BT302 neurosphere and its sorted subpopulations. Figure S9: HGF sustains the stem-like and invasive phenotype of Met-pos-NS.
Supplementary Table 1 from Leptin and Soluble Leptin Receptor in Risk of Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition Cohort
Authors: Aleksandrova Krasimira , Boeing Heiner , Jenab Mazda , Bueno-de-Mesquita H. Bas , Jansen Eugene , van Duijnhoven Fränzel J. B. , Rinaldi Sabina , Fedirko Veronika , Romieu Isabelle , Riboli Elio , Gunter Marc J. , Westphal Sabine , Overvad Kim , Tjønneland Anne , Halkjær Jytte , Racine Antoine , Boutron-Ruault Marie-Christine , Clavel-Chapelon Françoise , Kaaks Rudolf , Lukanova Annekatrin , Trichopoulou Antonia , Lagiou Pagona , Trichopoulos Dimitrios , Mattiello Amalia , Pala Valeria , Palli Domenico , Tumino Rosario , Vineis Paolo , Buckland Genevieve , Sánchez María-José , Amiano Pilar , Huerta José María , Barricarte Aurelio , Menéndez Virginia , Peeters Petra H. , Söderberg Stefan , Palmqvist Richard , Allen Naomi E. , Crowe Francesca L. , Khaw Kay-Tee , Wareham Nickolas , Pischon Tobias
Published: March 2023

PDF file - 58K, Median concentrations of leptin and sOB-R by tumor stage and cancer location, the European Prospective Investigation into Cancer and Nutrition (EPIC), 1992-2003
Supplementary Table 1 from Translation Initiation Factor eIF4E Is a Target for Tumor Cell Radiosensitization
Authors: Hayman Thomas J. , Williams Eli S. , Jamal Muhammad , Shankavaram Uma T. , Camphausen Kevin , Tofilon Philip J.
Published: March 2023

PDF file - 113K, List of 1124 genes whose binding to eIF4E was induced by radiation
Supplementary Figure and Movie Legends from CDK Inhibitors Upregulate BH3-Only Proteins to Sensitize Human Myeloma Cells to BH3 Mimetic Therapies
Authors: Chen Shuang , Dai Yun , Pei Xin-Yan , Myers Jennifer , Wang Li , Kramer Lora B. , Garnett Mandy , Schwartz Daniella M. , Su Florence , Simmons Gary L. , Richey Justin D. , Larsen Dustin G. , Dent Paul , Orlowski Robert Z. , Grant Steven
Published: March 2023

PDF file - 85K
Supplementary Figure 1 from CDK Inhibitors Upregulate BH3-Only Proteins to Sensitize Human Myeloma Cells to BH3 Mimetic Therapies
Authors: Chen Shuang , Dai Yun , Pei Xin-Yan , Myers Jennifer , Wang Li , Kramer Lora B. , Garnett Mandy , Schwartz Daniella M. , Su Florence , Simmons Gary L. , Richey Justin D. , Larsen Dustin G. , Dent Paul , Orlowski Robert Z. , Grant Steven
Published: March 2023

PDF file - 104K, FP/obatoclax induces dose-dependent mitochondrial injury and cell death in MM cells, accompanied by down-regulation of Mcl-1 protein and mRNA
Supplementary Figure 8 from Proangiogenic Factor PlGF Programs CD11b+ Myelomonocytes in Breast Cancer during Differentiation of Their Hematopoietic Progenitors
Authors: Laurent Julien , Hull Eveline Faes-van't , Touvrey Cedric , Kuonen François , Lan Qiang , Lorusso Girieca , Doucey Marie-Agnès , Ciarloni Laura , Imaizumi Natsuko , Alghisi Gian Carlo , Fagiani Ernesta , Zaman Khalil , Stupp Roger , Shibuya Masabumi , Delaloye Jean-François , Christofori Gerhard , Ruegg Curzio
Published: March 2023

Supplementary Figure 8 from Proangiogenic Factor PlGF Programs CD11b+ Myelomonocytes in Breast Cancer during Differentiation of Their Hematopoietic Progenitors
Supplementary Table S1 from LIN28B Polymorphisms Influence Susceptibility to Epithelial Ovarian Cancer
Authors: Permuth-Wey Jennifer , Kim Donghwa , Tsai Ya-Yu , Lin Hui-Yi , Chen Y. Ann , Barnholtz-Sloan Jill , Birrer Michael J. , Bloom Gregory , Chanock Stephen J. , Chen Zhihua , Cramer Daniel W. , Cunningham Julie M. , Dagne Getachew , Ebbert-Syfrett Judith , Fenstermacher David , Fridley Brooke L. , Garcia-Closas Montserrat , Gayther Simon A. , Ge William , Gentry-Maharaj Aleksandra , Gonzalez-Bosquet Jesus , Goode Ellen L. , Iversen Edwin , Jim Heather , Kong William , McLaughlin John , Menon Usha , Monteiro Alvaro N.A. , Narod Steven A. , Pharoah Paul D.P. , Phelan Catherine M. , Qu Xiaotao , Ramus Susan J. , Risch Harvey , Schildkraut Joellen M. , Song Honglin , Stockwell Heather , Sutphen Rebecca , Terry Kathryn L. , Tyrer Jonathan , Vierkant Robert A. , Wentzensen Nicolas , Lancaster Johnathan M. , Cheng Jin Q. , Sellers Thomas A.
Published: March 2023

Supplementary Table S1 from LIN28B Polymorphisms Influence Susceptibility to Epithelial Ovarian Cancer
Supplementary Figure 2 from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance
Authors: Zhang Lei , Pickard Karen , Jenei Veronika , Bullock Marc D. , Bruce Amanda , Mitter Richard , Kelly Gavin , Paraskeva Christos , Strefford John , Primrose John , Thomas Gareth J. , Packham Graham , Mirnezami Alex H.
Published: March 2023

PDF file, 3629K, MiR-153 expression in pilot series of tumour samples.
Supplementary Figure 6 from Mutationally Activated PIK3CAH1047R Cooperates with BRAFV600E to Promote Lung Cancer Progression
Authors: Trejo Christy L. , Green Shon , Marsh Victoria , Collisson Eric A. , Iezza Gioia , Phillips Wayne A. , McMahon Martin
Published: March 2023

PDF file, 116K, Cooperative effects of combined pharmacological blockade BRAFV600E and PIK3CAH1047R signaling on BRAFV600E/PIK3CAH1047R/TP53null lung cancer derived cells assessed by Crystal Violet staining and validation of the effects of inhibitors in cell lysates analyzed by RPPA.
Supplementary Figures 1 through 5 from Tumor Hypoxia Does Not Drive Differentiation of Tumor-Associated Macrophages but Rather Fine-Tunes the M2-like Macrophage Population
Authors: Laoui Damya , Van Overmeire Eva , Di Conza Giusy , Aldeni Chiara , Keirsse Jiri , Morias Yannick , Movahedi Kiavash , Houbracken Isabelle , Schouppe Elio , Elkrim Yvon , Karroum Oussama , Jordan Bénédicte , Carmeliet Peter , Gysemans Conny , De Baetselier Patrick , Mazzone Massimiliano , Van Ginderachter Jo A.
Published: March 2023

PDF - 410K, Molecular and functional heterogeneity of TAM and TADC subsets in 3LL-R tumors (S1); Characterization of the myeloid cell infiltrate in orthotopic 3LL-R tumors and effect of tumor growth on the lung macrophage subsets (S2); Intratumoral localization of the distinct myeloid cell subpopulations in 3LL-R tumors (S3); PHD2-haplodeficiency increases tumor vessel perfusion and vessel coverage in 3LL-R tumors (S4); Expression of hypoxia-regulated proteins in sorted TAM (S5).
Supplementary Table 2 from Mixed Lineage Kinase MLK4 Is Activated in Colorectal Cancers Where It Synergistically Cooperates with Activated RAS Signaling in Driving Tumorigenesis
Authors: Martini Miriam , Russo Mariangela , Lamba Simona , Vitiello Elisa , Crowley Emily Hannah , Sassi Francesco , Romanelli Davide , Frattini Milo , Marchetti Antonio , Bardelli Alberto
Published: March 2023

PDF file - 30K, Primers used for PCR amplification and sequencing of the MLK4 exons in tumor samples.
Supplementary Figure 1 from Natural Human Plasmacytoid Dendritic Cells Induce Antigen-Specific T-Cell Responses in Melanoma Patients
Authors: Tel Jurjen , Aarntzen Erik H.J.G. , Baba Tetsuro , Schreibelt Gerty , Schulte Barbara M. , Benitez-Ribas Daniel , Boerman Otto C. , Croockewit Sandra , Oyen Wim J.G. , van Rossum Michelle , Winkels Gregor , Coulie Pierre G. , Punt Cornelis J.A. , Figdor Carl G. , de Vries I. Jolanda M.
Published: March 2023

Supplementary Figure 1 PDF file - 34K, Supplementary Figure 1 CliniMACS-based pDC isolation is feasible
Supplementary Figure 3 from Myeloid-Specific Expression of Ron Receptor Kinase Promotes Prostate Tumor Growth
Authors: Gurusamy Devikala , Gray Jerilyn K. , Pathrose Peterson , Kulkarni Rishikesh M. , Finkleman Fred D. , Waltz Susan E.
Published: March 2023

PDF file - 138K, qRT-PCR analysis of cytokines in the tumor proper and Ron expression in purified cell populations. For Review and Publication Both.
Supplementary Figure 2 from Myeloid-Specific Expression of Ron Receptor Kinase Promotes Prostate Tumor Growth
Authors: Gurusamy Devikala , Gray Jerilyn K. , Pathrose Peterson , Kulkarni Rishikesh M. , Finkleman Fred D. , Waltz Susan E.
Published: March 2023

PDF file - 80K, Ron loss in the tumor microenvironment increases macrophage cell death. For Review and Publication Both.
Supplementary Figure 3 from mTOR Inhibitors Block Kaposi Sarcoma Growth by Inhibiting Essential Autocrine Growth Factors and Tumor Angiogenesis
Authors: Roy Debasmita , Sin Sang-Hoon , Lucas Amy , Venkataramanan Raman , Wang Ling , Eason Anthony , Chavakula Veenadhari , Hilton Isaac B. , Tamburro Kristen M. , Damania Blossom , Dittmer Dirk P.
Published: March 2023

PDF file - 102K, Suppl. Figure 3: Reversibility of rapamycin-induced tumor inhibition in vivo supports a tumor static mechanism of action.
Supplementary Figure 1 from mTOR Inhibitors Block Kaposi Sarcoma Growth by Inhibiting Essential Autocrine Growth Factors and Tumor Angiogenesis
Authors: Roy Debasmita , Sin Sang-Hoon , Lucas Amy , Venkataramanan Raman , Wang Ling , Eason Anthony , Chavakula Veenadhari , Hilton Isaac B. , Tamburro Kristen M. , Damania Blossom , Dittmer Dirk P.
Published: March 2023

PDF file - 41K, Suppl. Figure 1: Inhibition of VEGF secretion of PEL cells by rapamycin as measured by ELISA and bioassay.
Supplementary Figure Legend from PTEN Loss Mitigates the Response of Medulloblastoma to Hedgehog Pathway Inhibition
Authors: Metcalfe Ciara , Alicke Bruno , Crow Ailey , Lamoureux Marlea , Dijkgraaf Gerrit J.P. , Peale Franklin , Gould Stephen E. , de Sauvage Frederic J.
Published: March 2023

PDF file - 57K
Supplementary Movie 1 from Automated Tracking of Nanoparticle-labeled Melanoma Cells Improves the Predictive Power of a Brain Metastasis Model
Authors: Sundstrøm Terje , Daphu Inderjit , Wendelbo Ingvild , Hodneland Erlend , Lundervold Arvid , Immervoll Heike , Skaftnesmo Kai Ove , Babic Michal , Jendelova Pavla , Sykova Eva , Lund-Johansen Morten , Bjerkvig Rolf , Thorsen Frits
Published: March 2023

MP4 file - 195K, SPION positive H2 cells at 24 hours
Supplementary Tables 1 - 2 from PME-1 Modulates Protein Phosphatase 2A Activity to Promote the Malignant Phenotype of Endometrial Cancer Cells
Authors: Wandzioch Ewa , Pusey Michelle , Werda Amy , Bail Sophie , Bhaskar Aishwarya , Nestor Mariya , Yang Jing-Jing , Rice Lyndi M.
Published: March 2023

PDF file - 340K, Table S1. siRNA and shRNA sequences targeting the gene PPME1, which codes for PME-1 protein. Table S2. Tumor and normal adjacent tissue (NAT) matched pairs were purchased from Proteogenex.
Supplementary Figure 2 from Tissue Damage–Associated “Danger Signals” Influence T-cell Responses That Promote the Progression of Preneoplasia to Cancer
Authors: He Ying , Zha Jikun , Wang Yamin , Liu Wenhua , Yang Xuanming , Yu Ping
Published: March 2023

PDF file - 41K, Few infiltrating immune cells in the prostate of young or old WT mice
Supplementary Materials and Methods and Figure Legends from Therapeutic PD-1 Pathway Blockade Augments with Other Modalities of Immunotherapy T-Cell Function to Prevent Immune Decline in Ovarian Cancer
Authors: Duraiswamy Jaikumar , Freeman Gordon J. , Coukos George
Published: March 2023

PDF file, 122K.
Supplementary Figure Legends from Metalloprotease-Mediated Tumor Cell Shedding of B7-H6, the Ligand of the Natural Killer Cell–Activating Receptor NKp30
Authors: Schlecker Eva , Fiegler Nathalie , Arnold Annette , Altevogt Peter , Rose-John Stefan , Moldenhauer Gerhard , Sucker Antje , Paschen Annette , von Strandmann Elke Pogge , Textor Sonja , Cerwenka Adelheid
Published: March 2023

PDF file - 70KB
Supplementary Table S2 from Amplification of FRS2 and Activation of FGFR/FRS2 Signaling Pathway in High-Grade Liposarcoma
Authors: Zhang Keqiang , Chu Kevin , Wu Xiwei , Gao Hanlin , Wang Jinhui , Yuan Yate-Ching , Loera Sofia , Ho Kimberley , Wang Yafan , Chow Warren , Un Frank , Chu Peiguo , Yen Yun
Published: March 2023

Supplementary Table S2 PDF file 122K, Immunohistochemical staining and FISH results of DDLS
Supplementary Figure 3 from AMPK Activation by Oncogenesis Is Required to Maintain Cancer Cell Proliferation in Astrocytic Tumors
Authors: Ríos Marcos , Foretz Marc , Viollet Benoit , Prieto Angel , Fraga Máximo , Costoya Jose A. , Señarís Rosa
Published: March 2023

PDF file - 109K, Supplemental figure 3. Characterization of AMPK role in proliferation of astrocytes with HRasV12 expression and human glioblastoma cell lines.
Supplementary Figures 1 - 7 from 14-3-3ζ Orchestrates Mammary Tumor Onset and Progression via miR-221–Mediated Cell Proliferation
Authors: Rehman Sumaiyah K. , Li Shau-Hsuan , Wyszomierski Shannon L. , Wang Qingfei , Li Ping , Sahin Ozgur , Xiao Yi , Zhang Siyuan , Xiong Yan , Yang Jun , Wang Hai , Guo Hua , Zhang Jitao D. , Medina Daniel , Muller William J. , Yu Dihua
Published: March 2023

PDF file - 1165K, Characterization of 14-3-3zeta Transgenic Mice and Mammary Tumors (S1); Analysis of Metastasis in Mammary Tumors (S2); Apoptosis Assays in Transgenic Mice and Cell Lines (S3); IHe Staining of Ki-67 and p21 Expression (S4); p27-Targeting miRNA Expression in Human Breast Cancer Cell Lines (S5); Analysis of Signaling Pathways Involved in 14-3-3zeta-Mediated miR-221 Transcriptional Upregulation (S6); Logistic regression model (S7).
Supplementary Figure 2 from Low PIP4K2B Expression in Human Breast Tumors Correlates with Reduced Patient Survival: A Role for PIP4K2B in the Regulation of E-Cadherin Expression
Authors: Keune Willem-Jan , Sims Andrew H. , Jones David R. , Bultsma Yvette , Lynch James T. , Jirström Karin , Landberg Goran , Divecha Nullin
Published: March 2023

PDF file - 383K, Cells as indicated were fixed and embedded in paraffin and sections were cut and mounted. The sections were stained with the PIP4K2BP6 antibody after antigen retrieval.
Supplementary Figure 1 from Endocrine Fibroblast Growth Factor FGF19 Promotes Prostate Cancer Progression
Authors: Feng Shu , Dakhova Olga , Creighton Chad J. , Ittmann Michael
Published: March 2023

PDF file - 684KB, Decreased viability of prostate cancer cells after FGF19 knockdown.
Supplementary Table 2 from A Circadian Clock Transcription Model for the Personalization of Cancer Chronotherapy
Authors: Li Xiao-Mei , Mohammad-Djafari Ali , Dumitru Mircea , Dulong Sandrine , Filipski Elisabeth , Siffroi-Fernandez Sandrine , Mteyrek Ali , Scaglione Francesco , Guettier Catherine , Delaunay Franck , Lévi Francis
Published: March 2023

PDF file - 78K, Plasma pharmacokinetic parameters (Mean plus/minus SEM) of irinotecan according to timing and chronotoxicity classes.
Supplementary Tables 1 - 3 from High-Throughput Tyrosine Kinase Activity Profiling Identifies FAK as a Candidate Therapeutic Target in Ewing Sarcoma
Authors: Crompton Brian D. , Carlton Anne L. , Thorner Aaron R. , Christie Amanda L. , Du Jinyan , Calicchio Monica L. , Rivera Miguel N. , Fleming Mark D. , Kohl Nancy E. , Kung Andrew L. , Stegmaier Kimberly
Published: March 2023

PDF file - 33K, Sequences for pLKO.1 FAK-targeting and CAS-targeting shRNAs (S1); Median fluorescent intensity for six Ewing sarcoma cell lines and 293FT cells measuring the phosphorylation level of 62 tyrosine kinases (S2); PF-562271 downregulates mTOR, AKT, and S6 phosphorylation (S3).
Supplementary Figure 6 from De Novo Design of a Tumor-Penetrating Peptide
Authors: Alberici Luca , Roth Lise , Sugahara Kazuki N. , Agemy Lilach , Kotamraju Venkata R. , Teesalu Tambet , Bordignon Claudio , Traversari Catia , Rizzardi Gian-Paolo , Ruoslahti Erkki
Published: March 2023

PDF file - 898K, iNGR does not increase the penetration of co-administered Evans blue dye into normal organs
Supplementary Figure 1 from Combined Anti-CD40 and Anti–IL-23 Monoclonal Antibody Therapy Effectively Suppresses Tumor Growth and Metastases
Authors: von Scheidt Bianca , Leung Patrick S.K. , Yong Michelle C.R. , Zhang Yu , Towne Jennifer E. , Smyth Mark J. , Teng Michele W.L.
Published: March 2023

PDF file - 114K, Anti-CD40/anti-IL-23p19 combination mAb therapy in mice bearing established RM-1 lung metastases is dependent on NK cells and IL-12p35.
Data Supplement from TLR7 Promotes Tumor Progression, Chemotherapy Resistance, and Poor Clinical Outcomes in Non–Small Cell Lung Cancer
Authors: Chatterjee Saradiya , Crozet Lucile , Damotte Diane , Iribarren Kristina , Schramm Catherine , Alifano Marco , Lupo Audrey , Cherfils-Vicini Julien , Goc Jeremy , Katsahian Sandrine , Younes Mohammad , Dieu-Nosjean Marie Caroline , Fridman Wolf Herman , Sautès-Fridman Catherine , Cremer Isabelle
Published: March 2023

Supplemental data. This supplemental data contains the supplemental figure legends and the supplemental tables 1 and 2 Supplemental table 1 describes the cohort of non treated NSCLC patients Supplemental table 2 describes the cohort of chemotherapy treated NSCLC patients
Supplementary Figure 2 from Apoptosis Imaging for Monitoring DR5 Antibody Accumulation and Pharmacodynamics in Brain Tumors Noninvasively
Authors: Weber Thomas G. , Osl Franz , Renner Anja , Pöschinger Thomas , Galbán Stefanie , Rehemtulla Alnawaz , Scheuer Werner
Published: March 2023

PDF file - 414KB, Supplementary Figure 2 - Fluorescence imaging after i.v. application of anti-DR5-Cy5 shows no specific antibody accumulation in the right brain hemisphere.
Supplementary Table 2 from Extracellular Vesicles Modulate the Glioblastoma Microenvironment via a Tumor Suppression Signaling Network Directed by miR-1
Authors: Bronisz Agnieszka , Wang Yan , Nowicki Michal O. , Peruzzi Pierpaolo , Ansari Khairul I. , Ogawa Daisuke , Balaj Leonora , De Rienzo Gianluca , Mineo Marco , Nakano Ichiro , Ostrowski Michael C. , Hochberg Fred , Weissleder Ralph , Lawler Sean E. , Chiocca E. Antonio , Godlewski Jakub
Published: March 2023

PDF file - 56K, SUPPLEMENTARY TABLE 2. Functional analysis of EV proteins identified by mass spectrometry.
Supplementary Methods, Figure Legend from Extracellular Vesicles Modulate the Glioblastoma Microenvironment via a Tumor Suppression Signaling Network Directed by miR-1
Authors: Bronisz Agnieszka , Wang Yan , Nowicki Michal O. , Peruzzi Pierpaolo , Ansari Khairul I. , Ogawa Daisuke , Balaj Leonora , De Rienzo Gianluca , Mineo Marco , Nakano Ichiro , Ostrowski Michael C. , Hochberg Fred , Weissleder Ralph , Lawler Sean E. , Chiocca E. Antonio , Godlewski Jakub
Published: March 2023

PDF file - 149K
Supplementary Figure Legends from p53 and NF-κB Coregulate Proinflammatory Gene Responses in Human Macrophages
Authors: Lowe Julie M. , Menendez Daniel , Bushel Pierre R. , Shatz Maria , Kirk Erin L. , Troester Melissa A. , Garantziotis Stavros , Fessler Michael B. , Resnick Michael A.
Published: March 2023

PDF file - 41K
Supplementary Figure 3 from Extracellular Vesicles Modulate the Glioblastoma Microenvironment via a Tumor Suppression Signaling Network Directed by miR-1
Authors: Bronisz Agnieszka , Wang Yan , Nowicki Michal O. , Peruzzi Pierpaolo , Ansari Khairul I. , Ogawa Daisuke , Balaj Leonora , De Rienzo Gianluca , Mineo Marco , Nakano Ichiro , Ostrowski Michael C. , Hochberg Fred , Weissleder Ralph , Lawler Sean E. , Chiocca E. Antonio , Godlewski Jakub
Published: March 2023

PDF file - 154K, FIGURE S3 related to FIGURE 4. Characterization of GBM-derived EVs.
Supplementary Figure 2 from Extracellular Vesicles Modulate the Glioblastoma Microenvironment via a Tumor Suppression Signaling Network Directed by miR-1
Authors: Bronisz Agnieszka , Wang Yan , Nowicki Michal O. , Peruzzi Pierpaolo , Ansari Khairul I. , Ogawa Daisuke , Balaj Leonora , De Rienzo Gianluca , Mineo Marco , Nakano Ichiro , Ostrowski Michael C. , Hochberg Fred , Weissleder Ralph , Lawler Sean E. , Chiocca E. Antonio , Godlewski Jakub
Published: March 2023

PDF file - 168K, FIGURE S2 related to FIGURE3. Effect of miR-1 overexpression on GBM cells in vitro.
Data Supplement from AR-Regulated TWEAK-FN14 Pathway Promotes Prostate Cancer Bone Metastasis
Authors: Yin JuanJuan , Liu Yen-Nien , Tillman Heather , Barrett Ben , Hewitt Stephen , Ylaya Kris , Fang Lei , Lake Ross , Corey Eva , Morrissey Colm , Vessella Robert , Kelly Kathleen
Published: March 2023

Supplemental Figure 2. (A) Representative IHC staining in tissue cores from UWTMA22. Shown are prostate cancer bone metastases with low to intermediate intensity in >95% of tumor cells (left) and intermediate to high intensity in >95% of tumor cells (right). B: bone. (B) Fn14 stain intensity (left panel) and extent (right panel) scores in TMA samples in different groups. *** P<0.001 vs metastasis. (C) Histological images of prostate cancer and bone metastasis sections stained for TWEAK. *: adenocarcinoma component. B: bone.
Supplementary Methods, Figures 1 - 13 from A Macrophage-Specific Fluorescent Probe for Intraoperative Lymph Node Staging
Authors: Yoo Jung Sun , Lee Sung-Chan , Jow Zhi Yen , Koh Pamela Yun Xiang , Chang Young-Tae
Published: March 2023

PDF file - 5664K, Supplementary Figure 1: Overview of high-throughput screening, Supplementary Figure 2: Synthesis scheme for MFP, Supplementary Figure 3: Identification spectra of MFP obtained by using 1H-NMR and 13C-NMR, Supplementary Figure 4: Identification LC-MS spectrum of MFP, Supplementary Figure 5: Physiochemical properties of MFP, Supplementary Figure 6: Macrophage differentiation with the U-937 cell line by using PMA stimulation, Supplementary Figure 7: Selective macrophage staining with MFP for different concentrations and incubation times, Supplementary Figure 8: Effect of MFP on cell viability, Supplementary Figure 9: Enrichment of T lymphocytes, monocytes and granulocytes from human blood, Supplementary Figure 10: Macrophage differentiation with peripheral blood monocytes, Supplementary Figure 11: Characterization of MFP+ cells in inflamed lymph nodes, Supplementary Figure 12: Characterization of MFP+ cells in metastatic lymph nodes, Supplementary Figure 13: Structural selectivity test with several analogues of MFP, Supplementary Methods.
Data Supplement from AR-Regulated TWEAK-FN14 Pathway Promotes Prostate Cancer Bone Metastasis
Authors: Yin JuanJuan , Liu Yen-Nien , Tillman Heather , Barrett Ben , Hewitt Stephen , Ylaya Kris , Fang Lei , Lake Ross , Corey Eva , Morrissey Colm , Vessella Robert , Kelly Kathleen
Published: March 2023

Supplemental Figure 4. (A) AR activity signature genes expressed as a summed Z score in metastatic samples separated on the basis of Fn14 expression above the median (Fn14 high) or below the median (Fn14 low) using the Grasso dataset. * p<0.05. (B) qChIP analysis was performed in DU145 cells expressing doxycycline induced AR. AR binding to the predicted AREs in the Fn14 promoter was determined either with or without prior DHT (5nM) treatment for 4 hours. The binding activity to each site is given as a percentage of total input then normalized to individual immunoglobulin G (IgG). (C) FACS analysis of human Fn14 promoter reporter in DU145 cells expressing Tet-on TA and TREG3-AR with or without prior doxycycline and DHT treatment.
Supplementary Figure 5 from Phosphorylation at Ser-181 of Oncogenic KRAS Is Required for Tumor Growth
Authors: Barceló Carles , Paco Noelia , Morell Mireia , Alvarez-Moya Blanca , Bota-Rabassedas Neus , Jaumot Montserrat , Vilardell Felip , Capella Gabriel , Agell Neus
Published: March 2023

PDF file - 25K, Fig. S5. GTP loading of endogenous Ras isoforms in the DLD1 KRAS wt/- cells expressing oncogenic KRAS phosphomutants.
Supplementary Figure Legends, Figures 1 - 4 from Foxp3+ T Cells Inhibit Antitumor Immune Memory Modulated by mTOR Inhibition
Authors: Wang Yanping , Sparwasser Tim , Figlin Robert , Kim Hyung L.
Published: March 2023

PDF file - 308KB, Supplemental Figure 1. Tumor increases Tregs. The percent of CD4 cells expressing FoxP3 were examined from lymph nodes, spleen, bone marrow and peripheral blood lymphocytes (PBL) from tumor (~1 cm in diameter)bearing mice and control mice without tumor (n=5 per group). Flow cytometry results and summary data are shown. Histograms provide mean + SEM. *p<0.0,***p<0.005. Supplemental Figure 2. αCD4 antibody depletes effector CD4 subtypes. a. Splenocytes (n=3 per group) were collected before (day 0) and 1 or 10 days after administering αCD4 antibody, and analyzed by flow cytometry. The number of total splenocytes staining for CD4 and IL-2, IL-4 or IL-17 is shown. b. Percent of CD4 cells staining for IL-2, IL-4 or IL-17 is shown. Histograms provide mean + SEM. Supplemental Figure 3. CD4 depletion and mTor inhibition enhanced the antitumor effect of DC vaccine in B6 mice implanted with B16 tumor cells. B16 tumor cells were implanted into B6 mice (n=5 per group) on day 0. Tumor-lysate pulsed DCs were administered on day 3. CD4 lymphocytes were depleted with αCD4 antibody on days 6 and 9. Mice were treated with daily temsirolimus on days 9 to 23. Tumor growth was monitored. *p<0.05, **p<0.01,***p<0.005. Supplemental Figure 4. CD4 depletion prior to immune stimulation prevents formation of CD8 memory cells. The experimental scheme is similar to Figure 4 (n=5 per group). An additional group is included where αCD4 antibody is administered on day -1 and +1 (Group A). a. The percent of CD8 cells expressing Thy1.1 is shown from splenocytes harvested 5 days following rechallenge of memory cells. b. The percent of CD8 cells expressing Eomes is shown. Histograms provide mean + SEM. *p<0.05, **p<0.01,***p<0.005.
Supplementary Figure 1 from Phosphorylation at Ser-181 of Oncogenic KRAS Is Required for Tumor Growth
Authors: Barceló Carles , Paco Noelia , Morell Mireia , Alvarez-Moya Blanca , Bota-Rabassedas Neus , Jaumot Montserrat , Vilardell Felip , Capella Gabriel , Agell Neus
Published: March 2023

PDF file - 51K, Fig. S1. Tumor volume of mice grafts from NIH3T3 cells expressing HA-KRAS-G12V phosphomutants.
Supplementary Figures 1 - 7 from CCL2/CCR2-Dependent Recruitment of Functional Antigen-Presenting Cells into Tumors upon Chemotherapy
Authors: Ma Yuting , Mattarollo Stephen R. , Adjemian Sandy , Yang Heng , Aymeric Laetitia , Hannani Dalil , Portela Catani João Paulo , Duret Helene , Teng Michele W.L. , Kepp Oliver , Wang Yidan , Sistigu Antonella , Schultze Joachim L. , Stoll Gautier , Galluzzi Lorenzo , Zitvogel Laurence , Smyth Mark J. , Kroemer Guido
Published: March 2023

PDF file - 544K, Influence of anthracycline-based chemotherapy on myeloid cells in distinct lymphoid organs (S1); Impact of chemotherapy on the expression of M1 and M2 macrophage-related genes by Ly6Chigh cells (S2); Anthracycline-based chemotherapy activates antigen-specific T cells within neoplastic lesions (S3); Anthracycline-based chemotherapy fails to affect the proliferation of antigen-specific T cells within tumor draining lymph nodes (S4); Anthracycline-based chemotherapy induces fluctuations in the circulating levels of various myeloid cell populations (S5); Chemotherapy regulates the expression of chemokine-encoding genes by tumor-infiltrating leukocytes (S6); Expression of Ccr2 on malignant cells and tumor-infiltrating CD11b+ cells (S7).
Supplementary Figure 2 from Netrin-1 Promotes Medulloblastoma Cell Invasiveness and Angiogenesis, and Demonstrates Elevated Expression in Tumor Tissue and Urine of Patients with Pediatric Medulloblastoma
Authors: Akino Tomoshige , Han Xuezhe , Nakayama Hironao , McNeish Brendan , Zurakowski David , Mammoto Akiko , Klagsbrun Michael , Smith Edward
Published: March 2023

PDF file - 52KB, Netrin-1 induces EC sprout.
Supplementary Figure 1 from Netrin-1 Promotes Medulloblastoma Cell Invasiveness and Angiogenesis, and Demonstrates Elevated Expression in Tumor Tissue and Urine of Patients with Pediatric Medulloblastoma
Authors: Akino Tomoshige , Han Xuezhe , Nakayama Hironao , McNeish Brendan , Zurakowski David , Mammoto Akiko , Klagsbrun Michael , Smith Edward
Published: March 2023

PDF file - 89KB, Netrin-1 induces phosphorylation of Erk.
Supplementary Table 1 from CBP Loss Cooperates with PTEN Haploinsufficiency to Drive Prostate Cancer: Implications for Epigenetic Therapy
Authors: Ding Liya , Chen Shuai , Liu Ping , Pan Yunqian , Zhong Jian , Regan Kevin M. , Wang Liguo , Yu Chunrong , Rizzardi Anthony , Cheng Liang , Zhang Jun , Schmechel Stephen C. , Cheville John C. , Van Deursen Jan , Tindall Donald J. , Huang Haojie
Published: March 2023

XLSX file - 9KB, Supplemental Table S1. Primers for genotyping, RT-qPCR and ChIP-qPCR.
Supplementary Figure 2 from Bcl2 Induces DNA Replication Stress by Inhibiting Ribonucleotide Reductase
Authors: Xie Maohua , Yen Yun , Owonikoko Taofeek K. , Ramalingam Suresh S. , Khuri Fadlo R. , Curran Walter J. , Doetsch Paul W. , Deng Xingming
Published: March 2023

PDF file - 154K, Expression of Bcl2 retards DNA replication via reduction of deoxyribouclotide synthesis and RNR activity in normal human bronchial epithelial (BEAS-2B) cells.
Supplementary Figure S6 from Endothelin A Receptor/β-Arrestin Signaling to the Wnt Pathway Renders Ovarian Cancer Cells Resistant to Chemotherapy
Authors: Rosanò Laura , Cianfrocca Roberta , Tocci Piera , Spinella Francesca , Di Castro Valeriana , Caprara Valentina , Semprucci Elisa , Ferrandina Gabriella , Natali Pier Giorgio , Bagnato Anna
Published: March 2023

Supplementary Figure S6. Analysis of ÃŽÂ²-arr1 and ETAR expression in human EOC samples.