bluuebunny/crossref_metadata_2025 huggingface dataset:
Tanggungjawab Hukum Institusi Rehabilitasi Medis Bagi Penyalahguna Narkoba
Authors: Wahyudi  , Mohamad Riyad Mintarja  , Nuryamin  , Farid Diana , Abdulah Pakarti Muhammad Husni , Surasa Ais
Published: February 2025

This research aims to measure the effectiveness of medical rehabilitation services provided by mandatory reporting institutions. Medical rehabilitation for drug addicts and substance abusers is a comprehensive effort aimed at freeing individuals involved in drug abuse from addiction. This rehabilitation can be carried out in healthcare facilities recognized and selected by the Ministry of Health, including Government and private healthcare facilities in collaboration with the government in providing drug rehabilitation services. Medical rehabilitation services play a crucial role in helping individuals who have committed legal violations reintegrate into society. This study adopts a qualitative research approach by implementing in-depth interviews with medical staff, rehabilitation participants, and institution supervisors. The research findings indicate that the effectiveness of medical rehabilitation services is significantly influenced by factors such as the competence of medical staff, the organized rehabilitation programs, support from various relevant parties, and hindering factors. The provision of medical rehabilitation services for drug addicts and substance abusers is regulated by the Minister of Health Regulation Number 4 of 2020 concerning the Implementation of Mandatory Reporting Institution, where Standard Operating Procedures have been well-established and defined to operate efficiently and optimally of medical rehabilitation services provided by Mandatory Reporting Institutions.
La scultura dell’«ottimo artista». Palingenesi estetico-amorosa in Marsilio Ficino, Giulio Camillo e Francesco Patrizi
Authors: Ghezzani Tommaso
Published: February 2025

Starting from the Corpus Hermeticum the intersection between philosophical-theological speculation and magical-civil action, embodied by animated simulacra, was of fundamental importance. The close link between the divine measurements of the animated statues and the poetic song, modulated according to specific linguistic proportions, was strongly codified. The hermetic teachings were deeply used by Marsilio Ficino. Following this line of investigation, the aim of this contribution is also to examine the relationship between statuary art and poetical magic within the Hermetic-Platonic trend, in particular regarding two great protagonists of it in Italy, after Ficino: Giulio Camillo and Francesco Patrizi da Cherso.
Les dessins de Francesco Salviati de la collection de Everard Jabach
Authors: Monbeig Goguel Catherine
Published: February 2025

The article aims to make known the seventeen drawings of The Louvre Museum, from the collection of the banker Everard Jabach, which the collector attributed to Francesco Salviati. These are exclusively «glued and framed» drawings described in the inventory drawn up at the time of the sale to Louis XIV, in 1671. Apart from the six well-known original drawings by this great maniera master, the other sheets are now reclassified under very different names.
Federico Zuccaro's artistic education as evidenced in his drawings
Authors: Mundy James
Published: February 2025

At the end of his life, Federico Zuccaro was a world-famous artist who had worked all over Europe for kings, queens, popes, cardinals and many influential and rich patrons of the arts. He had also founded art academies and authored both memoirs and theoretical treatises. Unlike his more artistically gifted and shorter-lived brother, Taddeo, Federico left behind extensive documentation of his activities, his successes and failures. As evidenced in his drawings, this article considers the influences on Federico’s artistic education, particularly those stemming from his brother’s tutelage – in a formal sense – in Taddeo’s atelier, where Federico was tasked with merging his art with that of his brother. This paper aims also to consider the influences of his observation of the natural world and his close study of both historical and contemporary artists, largely through his drawings. Finally, it investigates his attraction to the mechanics of social and political power and his desire to attain fame and material success in the competitive world of which he had chosen to navigate.
Per Antonio Cimatori, il Visacci, disegnatore: un gruppo di inediti dell’Albertina di Vienna
Authors: Zavatta Giulio
Published: February 2025

Starting from the crucial contributions to the subject by Philip Pouncey and, above all, Catherine Monbeig Goguel, the article reconsiders the draftsmanship of Antonio Cimatori, known as Il Visacci, an eccentric pupil of Federico Barocci in the Marche and Romagna between the late 16th and early 17th centuries. The attribution to Visacci of a group of sheets kept at the Albertina in Vienna constitutes the starting point for re-evaluating the originality of Visacci’s drawing work, influenced by Federico Barocci’s style but also open to other influences such as those of Federico Zuccari and Cavalier d’Arpino.
La política de clusters en la Comunidad Autónoma del País Vasco: una primera valoración
Authors:   Universidad de Deusto, Aranguren Mari José , Navarro Itziar ,   Universidad de Deusto
Published: February 2025

Ha transcurrido más de una década desde que una serie de agentes empezaron a dar los primeros pasos para la constitución de las asociaciones clusters y para el diseño de una política de clusters en la CAPV. Este artículo tiene por objetivo, en primer lugar, dar a conocer tales clusters, describiendo la política de clusters y las agrupaciones cluster existentes en la actualidad. A continuación, se aborda una primera valoración de dicha política. Consideramos que la política de clusters es, en general, positiva, puesto que, con una inversión relativamente reducida, se generan mecanismos para el diálogo y la cooperación en áreas estratégicas entre distintos agentes de la CAPV. En la última parte del artículo se presentan los retos que, a nuestro entender, se le plantean a la política de clusters de la CAPV.
El cluster del conocimiento en gestión empresarial en el País Vasco: aplicación de la metodología de M. Porter a su definición, análisis y potencial diagnóstico
Authors:   Universidad de Deusto, Rivera Olga
Published: February 2025

Este artículo analiza el Cluster del Conocimiento en Gestión Empresarial en el País Vasco, para avanzar en el diseño de una metodología de estudio de su realidad económica e institucional, en la forma de evaluación de sus principales fortalezas y debilidades, y en la identificación del grado de avance experimentado con respecto al diagnóstico que para él inicialmente se realizó en 1996. Para ello se aplica de modo estricto la metodología porteriana de análisis cluster. Las principales conclusiones de todo ello son que para comprender la realidad económica e institucional del Cluster del Conocimiento en Gestión es preciso estudiar un Cluster más amplio: el Cluster de Educación y Creación de Conocimiento; que las fortalezas y debilidades de aquel se encuentran relacionadas con las del sistema de innovación con el que está interconectado, cuestión que se ilustra a través del estudio del sector universitario en la CAPV; y que la mejora de dicho cluster requiere trascender el análisis estricto de sus componentes e interrelaciones, ampliar el ámbito de análisis a los dos niveles anteriores y abordar de forma consistente nuevos niveles de diálogo e interacción.
Ciudades y valores
Authors:   Bilbao Metrópoli-30, Martínez Cearra Alfonso
Published: February 2025

Mientras el origen de las ciudades globales está a menudo ligado al poder político y a la función de capitalidad y centro de coordinación del mercado nacional, las nuevas ciudades-región surgen de la actividad económica concentrada territorialmente, y por ello la manera en que se insertan en las redes globales también responde a lógicas diferentes. Hasta ahora, la mayoría de los planes estratégicos de ciudades ha puesto el énfasis en las ventajas competitivas asociadas a la creación de infraestructuras, acompañadas, frecuentemente, de inversiones en otros activos y servicios materiales. Pero las infraestructuras, siendo absolutamente necesarias para el proceso de revitalización, no deben hacer perder de vista que son las personas las que actúan como motores de dicho proceso. Los valores reconocidos como fundamentales para el desarrollo competitivo y sostenible de una ciudad como Bilbao, y sobre los que en consecuencia debe girar el Foro Mundial de Valores para el Desarrollo de la Ciudad se han establecido alrededor de la innovación, la profesionalidad, el sentido comunitario, la identidad y la apertura al exterior.
The Intersection of History and Race in American Media
Authors: Jiang Suri
Published: February 2025

As media consumers, individuals are directly influenced by the messages the media portrays. As a result, negative representations of minority groups have directly affected the social status of these communities in American culture. This research paper analyzes the portrayals of African-American, Asian-American, and Hispanic-American groups in American media to argue that American films use the intersection of racist history and media between white and non-white groups in order to marginalize minorities. Specific U.S. commercials and films from the early twentieth century to the present will be used as case studies to support this argument. Comparisons are drawn from the media’s usage of the history of slavery, stereotypical traits of these groups, and the U.S.-Mexican border to illustrate the different ways film misrepresents minorities.
Pelatihan Penerbangan Pesawat Drone Untuk Siswa SMK Al Farabi Medan
Authors: Andrian Andrian , Agustina Ika , Lubis Reniwati , Anwar Khairil , Aziz Prily Fitria , Frianto Herri Trisna
Published: February 2025

Unmanned aircraft or better known as drones have experienced rapid development in recent years. This technology has been used in various sectors, including military, agriculture, aerial photography, mapping, to surveillance and rescue. Along with the increasing demand and use of drones, skilled human resources are needed to operate and manage this technology safely and effectively. Lack of understanding of flight regulations, basic operating techniques, and drone maintenance can lead to the risk of accidents and violations of the law. Therefore, drone flight training for SMK Al Farabi Medan students is very important to ensure that drone operators have adequate competence. With this training, it is hoped that students can operate drones professionally, understand the technical and legal aspects involved, and be able to apply this technology optimally in their respective fields. This training also supports efforts to improve flight safety and more responsible management of drone technology.
EMOTIONAL REGULATION AS A MEDIATOR OF PERSONALITY TRAITS AND MARITAL SATISFACTION AMONG ACADEMIC STAFF IN COLLEGES OF EDUCATION IN OYO STATE
Authors: OYINKANSOLA ODEBUNMI  , SABINA N. OBI
Published: February 2025

This study explores how emotional regulation mediates the relationship between personality traits and marital satisfaction among academic staff in Colleges of Education in Oyo State. The study seeks to evaluate marital satisfaction in relation to sexual relationships, financial management, and communication. It will analyse key personality traits such as openness, conscientiousness, extraversion, agreeableness, and neuroticism, while also investigating the impact of emotional regulation techniques, including cognitive reappraisal and suppressive expression, on the relationship between these traits and marital satisfaction. A descriptive survey design was utilised, encompassing 1,150 academic staff from five operational colleges, chosen through intact sampling. The data collection involved a questionnaire that assessed marital satisfaction, personality traits, and emotional regulation, achieving a reliability coefficient of α = 0.827. Descriptive and inferential statistics were utilised, demonstrating notable impacts of emotional regulation on marital satisfaction, especially regarding communication. The findings highlight that the satisfaction with communication among staff is significantly high, probably attributed to their teaching responsibilities, while agreeableness emerged as a common personality trait. The influence of personality traits on marital satisfaction was mediated by emotional regulation, underscoring the importance of counselling and emotional management programs to improve interpersonal harmony within marital relationships.
TARBIYACHILARDA NUTQMADANIYATINING O‘ZIGA XOS XUSUSIYATLARI
Authors: Abdullayeva Kamola
Published: February 2025

Mazkur tezisda tarbiyachilarning kasbiy faoliyatida nutq madaniyatining o‘rni va ahamiyatini yoritishga bag‘ishlangan. Tarbiyachilarning nutqi nafaqat pedagogik jarayonning samaradorligini oshiradi, balki tarbiyalanuvchilarda madaniy, ma’naviy va intellektual fazilatlarni shakllantirishda muhim vosita sifatida xizmat qiladi. Nutq madaniyati — bu so‘z boyligi, intonatsiya, talaffuz, grammatik to‘g‘rilik, hamda nutqning ma’naviy-estetik jihatlarini birlashtiruvchi murakkab tizimdir.
3D MODELLASHTIRISH ORQALI TABIIY CHARM VA MO’YNADAN KIYIM TAYYORLASHDA FOYDALANILADIGAN XOM ASHYOLARNI MINIMALLASHTIRISH
Authors: Esanova Ma’rifat G’ayratovna Temirova Gulnoz Ibodovna, Yuldasheva Sitorabonu Ramazonovna
Published: February 2025

Tabiiy charm va mo'yna xom ashyosidan kiyim tayyorlash jarayonida xom ashyo maydonidan chiqindisiz foydalanish muhim masala bo'lib hisoblanadi. Mahsulot ishlab chiqarishda hosil bo'ladigan turli xildagi charm va mo'yna qiyqimlaridan foydalanilib, tayyor mahsulot olinadi. Xom ashyo tayyor mahsulotga aylangunga qadar bir nechta jarayonlardan o'tadi bu jarayonlarda turli xildagi va o'lchamdagi charm va mo'yna bo'lakchalari hosil bo'ladi.
TASVIRIY SAN’ATDA INEGRASIYA JARAYONINING ILMIY NAZARIY ASOSLARI
Authors: Sidikova Mohira Saloxidinovna
Published: February 2025

Maqolada hozirgi kunda ta’lim inegrasiyasiining muhimligi, talabalarninig ijodkorligini rivojlantirishda integrasiyaning ahamiyati va bo’lajak tasviriy san’at o’qituvchilarini shaklllantirishda qalamtasvir va plastik anatomiya fanlarining o’zaro integrasiyasi haqida fikrlar yuritilgan
KORXONA EKSPORT FAOLIYATIDA RISKLAR VA ULARNI MINIMALLASHTIRISHDA ZAMONAVIY YECHIMLAR
Authors: KABULOV Azizbek
Published: February 2025

Ushbu maqola Korxona eksport faoliyatida risklar va ularni minimallashtirishda zamonaviy yechimlar mavzusiga bag‘ishlangan bo‘lib, eksport faoliyati bilan shug‘ullanuvchi korxonalarning duch keladigan asosiy risklari va ularni kamaytirish usullari tahlil qilinadi. Maqolada eksport risklarini turlariga qarab klassifikatsiya qilish, iqtisodiy, siyosiy, huquqiy va logistika bilan bog‘liq xavf-xatarlarni aniqlash va ularga qarshi samarali strategiyalarni ishlab chiqish masalalari muhokama qilinadi. Tadqiqot natijalari, eksport faoliyatini yanada samarali tashkil etish va risklarni kamaytirish maqsadida ishlovchi mutaxassislar va korxona rahbarlari uchun qimmatli ma'lumot manbai bo‘lib xizmat qiladi.
“АЛПОМИШ” ДОСТОНИДАГИ ЗИНДОН ВОҚЕАСИ ВА ҲАКИМБЕКНИНГ СИНОВЛАРИ
Authors: Соннибоев Олим Нодирович
Published: February 2025

Алпомиш” халқ қаҳрамонлик эпоси ҳисобланиб, унда қаҳрамонлик, мардлик, миллатпарварлик, адолат, ўзаро қўшничилик, ватанпарварлик, биродарлик, вафодорлик туйғулари намоён этилган. Мазкур асар  минг йиллардан буён вужудга келиб, асрлар давомида халқ бахшилари, шоирлар томонидан  куйга солиниб, такомиллашиб келди. Ўзбекнинг узоқ ўтмиши, расм-русумлари, ҳаёт  тажрибасидан ўтган анъаналари, курашлари, ташвишлари, қувончлари ўзининг  бадиий ифодасини топган достонда Алпомишнинг жасорати, Барчиной садоқати, Қоражон, Қалдирғочой каби бир қатор образлар тасвирланган бўлиб, қуйида  «Алпомиш» достонидаги асосий образларга тавсиф бериб, бугунги кун ёшлари онгига қандай таъсир қилишига эътибор қаратамиз.
KIYIM TAYYORLASH JARONIDAGI ASOSIY TEXNOLOGIK JARAYONLAR VA TALABLAR
Authors: Muxammadova Zebiniso Olimovna, Temirova Gulnoz Ibodovna, Yuldasheva Sitorabonu Ramazonovna
Published: February 2025

Inson tanasini himoya qiluvchi har qanday kiyim gigiyenik va texnikaviy jihatdan uning nimaga mо’lallanganiga mos bо’lishi zarur. Ustki va qishgi kiyimlar issiq saqlaydigan, yengil va yozgi kiyimlar issiqlikka yuqori darajada qarshilik kо’rsatadigan, plash suv о’tkazmaydigan, ich kiyim esa havo va bug’ni  yaxshi о’tkazadigan, nam shimadigan bо’lishi kerak. Texnologik qulay bo’lgan har qanday kiyim ma’lum daraja pishiq, chidamli bо’lishi, maksimal darajada yengil va mayin bо’lishi asosiy talablardan.
ҲАМЗА ШАХСИЯТИ, АДАБИЁТИ ВА АБАДИЯТИ
Authors: Хўжамбердиев Шерзод
Published: February 2025

Мазкур мақолада Ҳамза Ҳакимзоданинг шахсияти, бу масалага бугунги кун назари билан қараш, ўтмишда шоир шахсияти юзасидан баёнланган битикларга муносабат, шоир ҳаёт йўлидаги энг муҳим нуқталар, бу серқирра ижодкорнинг адабиёт ва санъатнинг турли соҳалари бўйича ёзган асарлари, маориф ва миллий маданият соҳалари бўйича қилган ишлари юзасидан мухтасар сўз юритилади. Шу билан бирга, Ҳамза Ҳакимзода шахсияти ва асарларига бугунги мезонлар билан қараш қай даражада эканлиги хусусидаги мулоҳазалар баён қилинади. Эндиликда адибнинг асарларига қай йўсинда ёндашув кераклиги борасида ҳам айрим таклифлар берилади. Истиқлол даврида бу серқирра ижодкорнинг шахсияти ва фаолиятига баҳо беришда амалга оширилган ишлар, турли  позициядан туриб ёзилган баъзи мақолалар, ҳужжатли бадиий асарларга муносабат ҳам эътибордан четда қолмаган.
Spectators Onstage: Metatheatrical Experiments in Early Tom Stoppard
Authors: V Iswarya
Published: February 2025

While listing the ground-breaking contributions of twentieth-century theatre practitioners and theorists in incorporating the audience into the scheme of performance, the metaphysical engagement of the spectators in the Theatre of the Absurd and the emerging metatheatre of the same period is often overlooked. Tom Stoppard’s early experimental plays The Real Inspector Hound and Rosencrantz and Guildenstern are Dead serve as an important link in the contemporary theatrical innovation of dissolving the strict demarcation between actors and audiences while eschewing the methods of later theatre makers who use more direct and even intrusive forms of engaging with the audience in the theatre. The present paper analyses Tom Stoppard’s attempt to include the spectator within the drama and expand the idea of spectatorship itself through his plays.
Bodily Humor and Ideologies of Disability in Joey Pigza Swallowed the Key
Authors: Ragan Shelby
Published: February 2025

There is a scarcity of protagonists with disabilities in children’s literature, but one series that has received both critical and popular attention is the Joey Pigza series by Jack Gantos. This paper explores the use of humor in the first book of the series, Joey Pigza Swallowed the Key. Drawing on theories of humor by scholars such as David Russell, Julie Cross, and Roderick McGillis, the paper frames the use of humor, particularly bodily humor, as means of giving a voice to the protagonist as well as critiquing the ideologies around disabilities in education. Ultimately, though, it argues that beyond the critique, the text still reaffirms problematic ideologies about normalcy that undermine the overt critique.
What Cannot Be (Re)written: Disentangling Panoptic Structures in Charlotte Perkins Gilman's "The Yellow Wall-paper" and Herland
Authors: Fox Heather
Published: February 2025

Jeremy Bentham’s Panopticon was an architectural response to an eighteenth-century problem, positioning inmates’ bodies relative to the watchtower to perpetuate a sense of constant visibility. But the Panopticon’s design is not dependent on a prison setting; it can be evoked in any setting that constructs a panoptic relationship between the observer and the observed. The paper argues that the settings and patriarchal ideology locate protagonists’ bodies within panopticon-like surveillance in Charlotte Perkins Gilman’s “The Yellow Wallpaper” and Herland. They are subjects without agency who, despite resistance, perpetuate the design they attempt to overturn. Whether structured as a prison (Bentham’s Panopticon), a nursery (the narrator’s room in “The Yellow Wallpaper”), or a utopia (the all-female society of Herland) the psychological effects of the infrastructure remain intact. The paper concludes that it is impossible to eliminate the Panopticon within the shadow of the Panopticon because its design perpetuates its effect. Until ideology is revised the narrative, despite its repositioning, remains strikingly similar.
Feminist Epistemology and the Web-based Text: Reflections on Raya Sarkar's List
Authors: Sarmah Raginee
Published: February 2025

Raya Sarkar’s list of ‘alleged sexual harassers’ in the academia, without names and personal narratives, is a text which frames a new turn in our understanding of feminist politics. The ‘List’ (with a capital l) is not an ordinary inventory but a potent text which transforms the diurnal activity of list making. In the length of a year, the List has begun to acquire a form of canonicity given the excess of literature being produced on it and the conflicting readings it sustains. The List can be observed as a cultural text with contextual adaptations being curated, with variance in context, modality, and location. In a short span of time several new lists have been created and circulated on basis of which the essay argues that if the act of listing can be seen as an act of reordering, is it a worldview that is being reordered? Does the List as a text allow the ‘concealment,’ if not the ‘death’ of its ‘author’? What contexts limit this text and what contexts does it transcend? These are a few enquiries which will inform the textual interrogation of these web-based processes with a specific focus on the List, and it is in the gaps of information that this paper seeks to find sites of critical analysis.
Trial by Silence and A Lonely Harvest by Perumal Murugan
Authors: Sengupta Rituparna
Published: February 2025

In January 2015, Tamil writer, poet, and scholar, Perumal Murugan made a dramatic declaration on his Facebook page: “Author Perumal Murugan is dead. He is no God. Hence, he will not resurrect. Hereafter, only P Murugan, a teacher, will live.” 1 This was in response to the controversy around his book Maadhorubaagan, (2010; tr. One Part Woman, 2013) and the harassment he had to face at the hands of members of the influential Gounder caste community—from which he too hails—who alleged that his book ‘insulted’ Gounder women and Hinduism.
IMPLEMENTATION OF LEARNING MANAGEMENT SYSTEM AT SEMEN TONASA JUNIOR HIGH SCHOOL TO SUPPORT DIGITAL LEARNING
Authors: Asrul Asrul , Baihaqi  , Windayani Windayani , Aprita Ika Rezvani , Sri Agustina
Published: February 2025

The advancement of digital technology has transformed the education sector, encouraging institutions to adopt technology-based learning systems. One viable solution is the Learning Management System (LMS), which aims to enhance the efficiency and effectiveness of the learning process. This Community Partnership Program (PKM) focuses on implementing LMS at SMP Semen Tonasa as part of the school's digital transformation efforts in teaching and learning activities. The methods employed include training and mentoring for teachers and students on LMS utilization, followed by an evaluation to assess its impact on engagement and learning outcomes. The program consists of several stages, including needs analysis, LMS installation, user training, and monitoring and evaluation. The results indicate that LMS implementation improves teacher-student interaction, facilitates easier access to learning materials, and enhances flexibility in the learning process. Evaluation findings reveal that 99% of participants understood the benefits of LMS after training. Additionally, the system allows students to access materials anytime and anywhere, fostering greater engagement in learning. Despite challenges such as adapting to a new system and infrastructure limitations, continuous mentoring helps overcome these obstacles. The LMSimplementation at SMP Semen Tonasa is expected to serve as a model for other educational institutions looking to integrate technology into their learning processes.
Impact of Ginger-containing Dentifrice for Use during Pregnancy on the Teeth Enamel Surface
Authors: Ballier Melissa , Degrazia Felipe Weidenbach , Xavier Tainá Maria , Dellazzana Fernando Zurlo , Camassola Melissa , Zanatta Rayssa Ferreira , Hilgert Leandro Augusto , Genari Bruna
Published: February 2025

Aim: Dental hygiene practices themselves can predispose pregnant women to nausea and vomiting, as changes in olfaction and taste may lead to intolerance to the taste and smell of oral hygiene products, potentially increasing the risk of oral diseases. Ginger has demonstrated an antiemetic effect and may serve as an alternative for preventing NVP. Incorporating ginger into a dentifrice could offer therapeutic benefits for managing NVP. This study aimed to evaluate an experimental dentifrice containing ginger with respect to its impact on cell viability and potential effects on tooth enamel.
Study Design: The ginger-containing dentifrice (GD) was formulated, and Colgate Total® 12 served as the control group (CG) to perform cell viability, flow, surface roughness and colorimetry tests. Place and Duration of Study: Faculty of Health Sciences of University of Brasilia and School of Dentistry of Federal University of Minas Gerais, Brazil. Between November 2022 and September 2024.
Methodology: Cell viability following direct contact with the experimental dentifrice was assessed using the MTT cytotoxicity assay (n=2), in accordance with ISO 10993-5. The flow test (n=3) was performed following ISO 6876 guidelines. Using a brushing simulator, 20 bovine incisors (n=10) were coated with 10 mL of dentifrice and 30 mL of water (1:3 ratio) and subjected to 10,000 brushing cycles. The enamel surfaces were analyzed before and after brushing to assess surface roughness (Ra, Rz, and Rq), changes in luminosity (ΔL), and variations in colorimetric parameters (ΔE and ΔE2000) according to their respective formulas. Data were analyzed using the t-test and Mann-Whitney test at a significance level of 5%, employing appropriate statistical software. The ginger dentifrice preserved cell viability after 24 hours of direct contact.
Results: The GD demonstrated a flow of 51.8 ± 0.6 mm, significantly higher than that of the CG (45.8 ± 0.6 mm). After brushing, no significant differences were observed between groups in final roughness values. Similarly, colorimetric analysis revealed no significant differences in ΔE (p=0.25) between the groups.
Conclusion: The GD did not induce cytotoxic effects, nor did it alter the roughness or color of tooth enamel.
Salivary gland transcriptomics of the cotton aphid Aphis gossypii and comparative analysis with other sap‐sucking insects
Authors: Pavithran Shanmugasundram , Murugan Marimuthu , Mannu Jayakanthan , Sathyaseelan Chakkarai , Balasubramani Venkatasamy , Harish Sankarasubramanian , Natesan Senthil
Published: June 2024

Aphids are sap‐sucking insects responsible for crop losses and a severe threat to crop production. Proteins in the aphid saliva are integral in establishing an interaction between aphids and plants and are responsible for host plant adaptation. The cotton aphid, Aphis gossypii (Hemiptera: Aphididae) is a major pest of Gossypium hirsutum. Despite extensive studies of the salivary proteins of various aphid species, the components of A. gossypii salivary glands are unknown. In this study, we identified 123,008 transcripts from the salivary gland of A. gossypii. Among those, 2933 proteins have signal peptides with no transmembrane domain known to be secreted from the cell upon feeding. The transcriptome includes proteins with more comprehensive functions such as digestion, detoxification, regulating host defenses, regulation of salivary glands, and a large set of uncharacterized proteins. Comparative analysis of salivary proteins of different aphids and other insects with A. gossypii revealed that 183 and 88 orthologous clusters were common in the Aphididae and non‐Aphididae groups, respectively. The structure prediction for highly expressed salivary proteins indicated that most possess an intrinsically disordered region. These results provide valuable reference data for exploring novel functions of salivary proteins in A. gossypii with their host interactions. The identified proteins may help develop a sustainable way to manage aphid pests.
Dietary supplement of sodium butyrate improves the growth performance and intestinal health by targeting Wnt/β‐catenin signaling pathway in rabbits
Authors: Ni Mengke , Wang Zhitong , Li Zhichao , Chen Mengjuan , He Hui , Cai Hanfang , Chen Zhi , Li Ming , Xu Huifen
Published: June 2024

Supplementation of sodium butyrate (SB) has been proved to be beneficial for improving the growth performance and health of animals, but its effects on rabbits have not been well understood. Therefore, this study aimed to investigate the effects of SB supplementation on growth performance, meat quality, and intestinal health of rabbits by evaluating feed intake and efficiency, diarrhea index, blood and cecum metabolites, cecal pH and short‐chain fatty acids (SCFAs), histological staining, nutritional composition of meat, and gene expression profile of cecum. A total of 14 weaned male New Zealand White rabbits (35 ± 2 days, 1.70 ± 0.09 kg) were randomly divided into two groups: rabbits in Control group were fed normally with the basal diet, and rabbits in Butyrate group were supplemented with 0.75 g/kg SB on the basis of the basal diet. After a 1‐week acclimatization period, the formal trial lasted for 10 weeks. Results suggest that dietary SB reduced the feed conversion ratio and diarrhea index of rabbits (p < 0.05). SB treatment significantly increased serum glutamyl transpeptidase, total bile acid, total cholesterol, triglyceride, and glucose levels and decreased tCO2 content relative to the Control group (p < 0.05). Meanwhile, crude ash content in rabbits' meat was significantly increased by SB treatment (p < 0.05). Furthermore, SB treatment significantly increased the integrity of epithelial villi and number of goblet cells in the cecum and decreased cecal pH compared with the Control group. Dietary SB also upregulated levels of Na+‐K+ ATPase, Ca2+‐Mg2+ ATPase, total superoxide dismutase, and glutathione peroxidase in cecum. SCFAs analysis revealed that dietary supplementation with SB increases butyric acid in the cecum contents. Furthermore, SB supplementation is demonstrated to stimulate the proliferation and migration of cecal epithelial cells through activating Wnt/β‐catenin pathways in rabbits both in vitro and in vivo by using transcriptome sequencing and gene function verification technologies. Taken together, our findings provide a theoretical basis for the application of SB as an alternative to antibiotics in livestock production.
Geochemistry of forty‐one eclogitic and pyroxenitic mantle xenoliths from the Central Slave Craton, Canada (Ekati Diamond Mine)
Authors: Jacob D. E. , Fung A.
Published: June 2024

This article describes a novel dataset on non‐diamondiferous eclogite and garnet pyroxenite xenoliths from four kimberlite pipes of the Ekati Diamond Mine (Central Slave Craton, Canada). Xenoliths brought to the surface by kimberlite eruptions are direct sources of information on the composition and evolution of the Earth's mantle. Eclogite and garnet pyroxenite xenoliths, specifically, are testimony of subduction into, and metasomatism of, the mantle beneath cratons. Furthermore, these rocks are major hosts for diamond and thus an important part of the deep carbon cycle. The sample suite consists of 41 small xenoliths (2–5 cm) recovered from drill cores. The dataset includes major and trace element concentrations for garnet, clinopyroxene and ilmenite, as well as stable oxygen isotope compositions of garnets. Strontium and neodymium isotopic compositions are reported for garnet and clinopyroxene for four samples which were large enough to allow for analysis. Overall, this dataset significantly expands and complements existing datasets on diamondiferous and non‐diamondiferous xenoliths from the Slave Craton in Canada, furthering our understanding of the composition of the Slave subcratonic lithosphere. The dataset includes several samples with rare mineral assemblages, including an olivine‐bearing eclogite as well as ilmenite and apatite‐bearing garnet‐pyroxenites, and thus provides data shedding light on rarely reported compositional nuances in xenolith suites found in kimberlites.
Relationships between matrix mineralization, oxidative metabolism, and mitochondrial structure during ATDC5 murine chondroprogenitor cell line differentiation
Authors: Blank Kevin , Ekanayake Derrick , Cooke Margaret , Bragdon Beth , Hussein Amira , Gerstenfeld Louis
Published: June 2024

The mechanistic relationships between the progression of growth chondrocyte differentiation, matrix mineralization, oxidative metabolism, and mitochondria content and structure were examined in the ATDC5 murine chondroprogenitor cell line. The progression of chondrocyte differentiation was associated with a statistically significant (p ≤ 0.05) ~2‐fold increase in oxidative phosphorylation. However, as matrix mineralization progressed, oxidative metabolism decreased. In the absence of mineralization, cartilage extracellular matrix mRNA expression for Col2a1, Aggrecan, and Col10a1 were statistically (p ≤ 0.05) ~2–3‐fold greater than observed in mineralizing cultures. In contrast, BSP and Phex that are associated with promoting matrix mineralization showed statistically (p ≤ 0.05) higher ~2–4 expression, while FGF23 phosphate regulatory factor was significantly lower (~50%) in mineralizing cultures. Cultures induced to differentiate under both nonmineralizing and mineralizing media conditions showed statistically greater basal oxidative metabolism and ATP production. Maximal respiration and spare oxidative capacity were significantly elevated (p ≤ 0.05) in differentiated nonmineralizing cultures compared to those that mineralized. Increased oxidative metabolism was associated with both an increase in mitochondria volume per cell and mitochondria fusion, while mineralization diminished mitochondrial volume and appeared to be associated with fission. Undifferentiated and mineralized cells showed increased mitochondrial co‐localization with the actin cytoskeletal. Examination of proteins associated with mitochondria fission and apoptosis and mitophagy, respectively, showed levels of immunological expression consistent with the increasing fission and apoptosis in mineralizing cultures. These results suggest that chondrocyte differentiation is associated with intracellular structural reorganization, promoting increased mitochondria content and fusion that enables increased oxidative metabolism. Mineralization, however, does not need energy derived from oxidative metabolism; rather, during mineralization, mitochondria appear to undergo fission and mitophagy. In summary, these studies show that as chondrocytes underwent hypertrophic differentiation, they increased oxidative metabolism, but as mineralization proceeds, metabolism decreased. Mitochondria structure also underwent a structural reorganization that was further supportive of their oxidative capacity as the chondrocytes progressed through their differentiation. Thus, the mitochondria first underwent fusion to support increased oxidative metabolism, then underwent fission during mineralization, facilitating their programed death.
Future exposure of rainfall and temperature extremes to the most populous island of Indonesia: A projection based on CORDEX simulation
Authors: Hendrawan Vempi Satriya Adi , Mawandha Hanggar Ganara , Sakti Anjar Dimara , Karlina  , Andika Neil , Shahid Shamsuddin , Jayadi Rachmad
Published: June 2024

The study focuses on understanding the future exposure to rainfall and temperature extremes in one of the world's most populous islands, Java, Indonesia. We use the high‐resolution climate projections from the Coordinated Regional Climate Downscaling Experiment (CORDEX) simulation for Southeast Asia by 2100 under RCP4.5 and RCP8.5 scenarios. Results show that the island will likely experience drying in the lowlands due to annual rainfall decline by approximately 13%–18%, potentially exposing around 27%–73% of the population (varying under different scenarios) during the end of the century (2060–2099). Additionally, the future drying condition may be exacerbated by extreme temperatures with a 1.7–3.1°C increase in maximum daily temperature, linked with more than half of the population (63%) likely to experience at least an unprecedented temperature of 3°C under RCP8.5. Our seasonal analysis also suggests that dry seasons get even drier, and wet seasons get wetter. In terms of landuse areas exposed, we show a higher fraction of crop and forest areas may face both drying and warming, which can potentially lead to crop failure and wildfire. Our study indicates that compound drought and heat may be a common threat in lowland Java in the future, while intensifying rainfall extremes in the uplands may lead to flash flooding downstream and landslides. These findings highlight the urgent need for adaptation and mitigation strategies to reduce the risks associated with climate change in Java as one of Indonesia's most critical regions in the future.
Growth and development of epiglottis and preepiglottic space of larynx as it acquires vocal tract
Authors: Sato Kiminori , Chitose Shun‐ichi , Sato Kiminobu , Sato Fumihiko , Ono Takeharu , Umeno Hirohito
Published: June 2024

Objectives

The growth and development of the epiglottis and preepiglottic space (PES) of the human larynx as it acquires the vocal tract were investigated.

Methods

Three newborns, one infant, four children (2, 7, 8, and 12 years old), and two adult normal larynges were investigated and compared using the whole organ serial section technique.

Results

The newborn PES occupied a small area just anterior to the epiglottis. It was composed of immature adipose tissue and areolar tissue. The epiglottis lay on a somewhat horizontal axis and is partially obscured behind the hyoid bone. The hyoid bone overlapped the thyroid cartilage, partially obscuring the superior thyroid notch. The newborn epiglottic cartilage was immature elastic cartilage, and the elastic fiber component was sparse. In the first 8 years of life, as the PES grew, the PES was located not only anterior to but also posterolateral and inferolateral to the epiglottic cartilage and thyroepiglottic ligament. Meanwhile, the epiglottic cartilage matured.

Conclusions

In order to develop the vocal tract for speech production, it is reported that the human larynx descends as the child grows in the first 9 years of life. This study showed that the PES, occupying a small area just anterior to the epiglottis, grew and existed astride the epiglottis as the larynx descended and the vocal tract developed. Consequently, its distribution allows the epiglottis to more effectively play the role of retroflection during swallowing in order to prevent aspiration. The human speech faculty likely develops in conjunction with swallowing physiology.
Atypical BCR‐ABL1 transcript in mixed phenotype acute leukemia with bone marrow necrosis
Authors: Liu Jiarui , Jiang Yujie , Yuan Dai , Zhang Zhifen , Liu Xin , Zhao Wenbo , Xu Hongzhi
Published: June 2024

Mixed phenotype acute leukemia (MPAL) is a type of acute leukemia in which encompasses mixed features of myeloid, T‐lymphoid, and/or B‐lymphoid differentiation. Philadelphia chromosome‐positive (Ph+) MPAL is a rare subgroup with a poor prognosis and accounts for ＜1% of adult acute leukemia. Until now, there is still no consensus on how to best treat Ph+ MPAL. Here, we report a 62‐year‐old male with Ph+ (atypical e13a2 BCR‐ABL1 fusion protein) MPAL. This patient presented with recurrent and intense bone pain due to bone marrow necrosis (BMN). Besides, he did not achieve a complete remission for the first two chemotherapies, until he received flumatinib combined with hyper‐CVAD (B) (a dose‐intensive regimen include methotrexate and cytarabine). To our knowledge, this is the first report to describe the coexistence of BMN and atypical e13a2 BCR‐ABL1 transcripts in patients with MPAL. This finding will bring new understandings in the diagnosis and treatment of Ph+ MPAL.
Autoimmune pulmonary alveolar proteinosis during the treatment of nonspecific interstitial pneumonia complicated by clinically amyopathic dermatomyositis: A case report
Authors: Arakawa Naoko , Shiota Yuno , Onizawa Fumi , Miyata Fumi , Miyoshi Azusa , Akaba Tomohiro , Tsuji Mayoko , Arimura Ken , Yagi Osamitsu , Kondo Mitsuko , Katsura Hideki , Tagaya Etsuko
Published: June 2024

A 46‐year‐old male was treated with corticosteroids for nonspecific interstitial pneumonia (NSIP). He was referred to our hospital and admitted for worsening dyspnea and diffuse ground‐glass opacity on chest computed tomography (CT) during corticosteroid treatment. Gottron's sign was observed, and the patient was diagnosed with clinically amyopathic dermatomyositis on skin biopsy. We increased the corticosteroid dose and added immunosuppressive agents; however, the opacity on the chest CT worsened. Based on periodic‐acid‐Schiff‐positive granular material in the bronchoalveolar lavage fluid and the presence of anti‐GM‐CSF antibodies, the patient was diagnosed with autoimmune pulmonary alveolar proteinosis (APAP). The concentration of anti‐GM‐CSF antibodies in preserved serum was also elevated when the patient was diagnosed with NSIP. Thus, we assumed that NSIP and APAP coexisted, and that APAP manifested during immunosuppressive therapy. When exacerbation is observed during the treatment of interstitial pneumonia with immunosuppressive agents, it is necessary to consider APAP.
A ciliated adenocarcinoma of the lung mimicking lung abscess and pneumonia
Authors: Fujimoto Naoki , Fujita Kohei , Ishida Ayami , Moriyoshi Koki , Tanizawa Kiminobu
Published: June 2024

This case report describes a 78‐year‐old man initially treated for pneumonia and lung abscess who was resistant to antimicrobial treatment and was eventually diagnosed with ciliated adenocarcinoma. Ciliated adenocarcinoma, a rare non‐terminal respiratory unit (TRU)‐type lung adenocarcinoma, presents a unique diagnostic challenge because of its similarity to pneumonia and lung abscesses. Morphologically, the ciliated adenocarcinoma in this case appeared to be a non‐TRU type adenocarcinoma, with partial mucous epithelium, no visible extracellular mucus, thyroid transcription factor (TTF)‐1 negativity, and mucin (MUC) 5AC positivity on immunostaining. The patient was considered to have ciliated adenocarcinoma based on the fact that the mucous epithelium was partial and extracellular mucus was not prominent. This case emphasizes the importance of considering malignancy in patients with non‐resolving pulmonary infections.
A new real‐time path planning for USV based on dynamic artificial potential field in complex environments
Authors: Lu Nan , Liu Hao , Wang Yueying , Yan Huaicheng
Published: June 2024

This article studies the problem of real‐time path planning for unmanned surface vessels (USVs) in complex environments. Although this problem has received increasing research attention recently, it is still unsolved to a large extent due to the complexity of obstacles and their high dynamics. In particular, the existing path planning approaches are only able to solve the simplest scenarios. The main contribution of this article is to propose a new dynamic artificial potential field to represent the influence of obstacles on the danger degree of the surrounding environment, which is an important step towards the uniform and appropriate description of dynamic and static obstacles in real‐time path planning. At the same time, based on state constraints of USV, the obstacle avoidance strategy consistent with the International Regulations for Preventing Collisions at Sea (COLREGs, short for Collision Regulations) is set up, and the optimal path is solved by genetic algorithm. Simulation results are presented to verify the effectiveness of the proposed method.
A case of hemorrhage at the junctions of the posterior intercostal arteries—a vital sign?
Authors: Lange-Herr Nicolas , Tschui Joëlle , Klaus Jeremias , Baglivo Manuela , Schlottke Emilie , Zech Wolf-Dieter
Published: June 2024

The authors present the case of a 58-year-old man found hanging from a radiator by his shoelaces. The time of death was approximately 6 h before the body was discovered. An autopsy was performed approximately 24 h after the body was found, which revealed hemorrhages in the thoracic aorta at the junctions of the posterior intercostal arteries. Before autopsy, a routine whole-body CT scan was performed. Histologic examination of the aorta and the posterior intercostal arteries revealed a fresh hemorrhage into the tunica adventitia of the aorta. To our knowledge, there is no case description of such findings in hanged persons in the literature. Conclusion: Hemorrhages into the tunica adventitia of the junction of the posterior costal arteries may occur in association with suicidal hanging. The significance of these hemorrhages as a sign of vitality may be debated.
Unveiling the invisible: a qualitative interview study on the impact of young onset Parkinson’s disease on (ex-)partners
Authors: Kapelle Willanka Mariëlle , Geerlings Angelika D. , Mutsaers Inge , Bloem Bastiaan R. , Meinders Marjan J. , Post Bart
Published: June 2024

Introduction

Living with young onset Parkinson’s disease (YOPD) not only affects the persons with YOPD, but also their families. Although caregiver burden has been researched in Parkinson’s disease in general, little is known about the specific impact of having an (ex-)partner with YOPD. This exploratory study aimed to explore the impact of having an (ex-)partner with YOPD on daily life.

Materials and methods

We used a qualitative approach including semi-structured interviews with 16 (ex-)partners of people with YOPD. Interviews were audio-taped and transcribed verbatim. Qualitative thematic analysis was used to analyze the interview data.

Results

Qualitative analysis revealed nine themes to describe the impact of having an (ex-)partner with YOPD: (1) Psychosocial impact, (2) Impact on taking care of children, (3) Impact on working life, (4) Impact on intimacy and (sexual) relationships, (5) Impact on daily life, (6) Acceptance and other coping strategies, (7) Thoughts about the future, (8) Autonomy and (9) Caregiver support.

Discussion

This study provides important findings that will inform future interventions that aim to reduce or even prevent caregiver burden, as well as to inform healthcare professionals to recognize the needs of caregivers of people with YOPD.
Exploring the interplay between angiosperm chlorophyll metabolism and environmental factors
Authors: Yong Shunyuan , Chen Qian , Xu Fan , Fu Hao , Liang Guolu , Guo Qigao
Published: June 2024

Main conclusion

In this review, we summarize how chlorophyll metabolism in angiosperm is affected by the environmental factors: light, temperature, metal ions, water, oxygen, and altitude.

The significance of chlorophyll (Chl) in plant leaf morphogenesis and photosynthesis cannot be overstated. Over time, researchers have made significant advancements in comprehending the biosynthetic pathway of Chl in angiosperms, along with the pivotal enzymes and genes involved in this process, particularly those related to heme synthesis and light-responsive mechanisms. Various environmental factors influence the stability of Chl content in angiosperms by modulating Chl metabolic pathways. Understanding the interplay between plants Chl metabolism and environmental factors has been a prominent research topic. This review mainly focuses on angiosperms, provides an overview of the regulatory mechanisms governing Chl metabolism, and the impact of environmental factors such as light, temperature, metal ions (iron and magnesium), water, oxygen, and altitude on Chl metabolism. Understanding these effects is crucial for comprehending and preserving the homeostasis of Chl metabolism.