bluuebunny/crossref_metadata_2025 huggingface dataset:
Анализ стратегических целей консолидации организаций в государственных корпорациях
Authors: Бакулина А.А. , Кандаурова Д.Ю.
Published: October 2024

В статье анализируется консолидация бизнеса организаций, входящих в состав государственных корпораций. Актуальность исследования обусловлена необходимостью эффективного управления и развития государственных корпораций, так как они играют важную роль в экономическом развитии страны. В данной статье авторами проанализированы открытые источники данных, полученные с официальных сайтов госкорпораций (Государственная корпорация «ВЭБ.РФ», Государственная корпорация «Ростех», Агентство по страхованию вкладов (АСВ), Государственная корпорация по атомной энергии («Росатом») и др.). Авторы приходят к выводу, в Российской Федерации крупные отечественные компании и корпорации создали собственную тенденцию консолидации бизнеса, достигая поставленных в своей деятельности стратегических целей. Несмотря на достигнутые успехи в развитии формирования стратегии консолидации организаций в составе госкорпораций, многие вопросы нуждаются в актуализации и разработке нового инструментария, что еще раз подчеркивает своевременность и необходимость проведения исследования по обозначенной теме.

The article examines the consolidation of businesses within organizations that are part of State Corporations. The relevance of the study is driven by the need for effective management and development of state corporations, as they play a significant role in the country's economic growth. In this article, the author analyzes data from public sources obtained from the official websites of state corporations (State Corporation "VEB.RF", State Corporation "Rostec," Deposit Insurance Agency (DIA), State Atomic Energy Corporation "Rosatom," and others). The authors conclude that in the Russian Federation, large domestic companies and corporations have established their own trend of business consolidation, achieving the strategic goals set in their operations. Despite the successes in developing a consolidation strategy for organizations within state corporations, many issues require further refinement and the development of new tools, which underscores the timeliness and necessity of research on this topic.
Perfis sociodemográfico e clínico de indivíduos com Atrofia Muscular Espinhal e de seus cuidadores
Authors: Guimarães Melo Natália , Balçanufo de Souza e Silva Geovane , De Ávila Cecília Rosa , Aguilera Rodrigues da Silva Francine , Ferreira Martins Ribeiro Maysa , De Araújo Morais Letícia
Published: October 2024

Objetivo. Analisar os perfis sociodemográfico e clínico de pessoas com Atrofia Muscular Espinhal (AME) e de seus cuidadores. Método. Estudo transversal, realizado em clínica de doenças neuromusculares de um centro de reabilitação. Foi utilizado um questionário com anamnese, identificação, perfis sociodemográfico e clínico. As variáveis categóricas foram apresentadas em frequência absoluta e relativa, e as variáveis contínuas pela média e desvio padrão.  Para comparação entre os tipos de AME foram utilizados o Qui-quadrado de Pearson e a ANCOVA, nível de significância de p<0,05. Resultados. Participaram do estudo 27 cuidadores e 32 pessoas com AME, sendo 17 participantes com AME do tipo III, 9 do tipo II e 6 do tipo I. A idade dos participantes com AME variou entre 1 e 59 anos, com maior prevalência do sexo masculino (53,1%). No nível de escolaridade, as prevalências foram o ensino superior (31,3%) e o fundamental (28,1%). Apenas 34,4% tinham histórico de AME na família. Com relação aos aspectos clínicos, 87,5% necessitavam de dispositivo auxiliar para locomoção. O uso de medicação específica para AME e de suporte respiratório foi mais comum entre pessoas com AME dos tipos I e II. Quanto aos cuidadores, a maioria era composta por pessoas do sexo feminino (96,3%), mães (74,1%) e que se dedicavam exclusivamente ao lar e aos cuidados do indivíduo com AME (88,9%). Conclusão. A maioria dos participantes com AME não tinha histórico da doença na família e necessitava de dispositivo auxiliar para locomoção. As mães foram as cuidadoras prevalentes.
A Novel Role for FERM Domain-Containing Protein 3 (FRMD3) in CKD
Authors: Kennedy CiarÁn , Doyle Ross , Gough Oisin , Mcevoy Caitriona , Anallen Susan MC , Hughes Maria , Sheng Xin , Crifo Bianca , Andrews Darrell , Gaffney Andrew , Rodriguez Javier , Kennedy Susan , Dillon Eugene , Crean Daniel , Zhang Weijia , Yi Zhengzi , Nair Viji , Susztak Katalin , Hirschhorn Joel , Florez Jose , Groop Per-Henrik , Sandholm Niina , Kretzler Matthias , Mckay Gareth J. , Mcknight Amy Jayne , Maxwell Alexander P. , Matallanas David , Dorman Anthony , Martin Finian , Conlon Peter J. , Sadlier Denise M. ,   Genie Consortium, Brennan Eoin , Godson Catherine
Published: October 2024

Background:

Currently there are limited methods to link disease severity and risk of disease progression in Chronic Kidney Disease (CKD). To better understand this potential relationship, we interrogated the renal transcriptomic profile of individuals with CKD with measures of CKD severity and identified FERM-domain containing protein 3 (FRMD3) as a candidate gene for follow-up study.

Methods:

RNA-seq was used to profile the transcriptome of CKD biopsies from the North Dublin Renal BioBank the results of which were correlated with clinical parameters. The potential function of FRMD3 was explored by interrogating the FRMD3 interactome and assessing the impact of lentiviral mediated FRMD3 knock down on human renal proximal tubule epithelial cells by assessing cell viability, metabolic activity, and structural markers.

Results:

We identified a subset of 93 genes which are significantly correlated with estimated glomerular filtration rate and percentage tubulointerstitial fibrosis at time of biopsy and with CKD progression 5 years post-biopsy. These results were validated against transcriptomic data from an external cohort of 432 nephrectomy samples. One of the top-ranking genes from this subset, FRMD3, has previously been associated with the risk of developing diabetic kidney disease. Interrogating the interactome of FRMD3 in tubule epithelial cells revealed interactions with cytoskeletal components of cell-cell junctions. Knockdown of FRMD3 expression in tubule epithelial cells resulted in increased pro-apoptotic activity within the cells as well as dysregulation of E-Cadherin.

Conclusions:

We have identified a panel of kidney-specific transcripts correlated with severity and progression of kidney disease, and from this have identified a possible role for FRMD3 in tubule cell structure and health.
Prevalence and Association of Pruritus and its Current Treatment during the First Year of Dialysis
Authors: van Lieshout Thomas S. , Driehuis Esmee , Abrahams Alferso C. , de Ruijter Violette , de Lange Sanne J. , Bonenkamp Anna A. , De Vriese An S. , Vernooij Robin W.M. , Kemperman Patrick M.J.H. , Rustemeyer Thomas , van Ittersum Frans J. , Penne Erik L. , van Jaarsveld Brigit C. ,   on behalf of the DOMESTICO study group
Published: October 2024

Key Points

Incident dialysis patients show a high prevalence of pruritus during the first year of dialysis, with pruritus being either persistent or fluctuating.

Medical treatment for pruritus does not improve quality of life within the 25% of patients with pruritus receiving it.

High prevalence, negative effect, and low treatment rate of pruritus urges for more awareness, for instance, by the means of patient reported outcomes.

Background

Pruritus is common in dialysis patients and associated with impaired health-related quality of life (HRQoL) and sleep disturbances. Its pathophysiology remains unclear, resulting in limited treatment options and lack of treatment guidelines. The exact trajectory of pruritus after dialysis initiation, nor the state of current medical treatment, has been studied.

Methods

Incident dialysis patients (N=1438) included in the Dutch nocturnal and home dialysis study to improve clinical outcomes were studied. Outcome parameters were prevalence of pruritus, severity of pruritus, and the use of antipruritic medication, repeatedly measured during the first year of dialysis. Associations between treatment, pruritus, and quality of life were longitudinally studied using linear mixed models.

Results

The prevalence of pruritus ranged from 50.5% to 56.6% during the first year of dialysis. Throughout the year, approximately 35% experienced persistent pruritus and 40% fluctuating pruritus. During follow-up, 21.5%–26.5% received medical treatment for pruritus. Emollients were associated with more severe pruritus (adjusted β=0.31; 95% confidence interval [CI], 0.15 to 0.48); the remaining treatments did not show any association. Pruritus was significantly associated with lower physical and mental HRQoL (adjusted β=−2.04; 95% CI, −2.78 to −1.30 and β=−1.73; 95% CI, −2.51 to −0.94, respectively), irrespective of treatment.

Conclusions

During the first year of dialysis, pruritus is highly prevalent, predominantly fluctuating, and associated with impaired HRQoL. The minority of patients received medical treatment; in our study, current treatment was not associated with an improvement of pruritus. These results highlight the need for more awareness among clinicians and for the development of effective treatment options.
التحولات الزمنية وأثرها في شعر القناع: قصيدة (قناع لمجنون ليلى) لمحمود درويش أنموذجًا.
Authors: الكلباني علي قاسم
Published: October 2024

تناول هذا البحث الإشكاليات الناتجة عن استعمال تقنية القناع في الشعر الحديث، ومن أهمّها التداخل في العوالم والتجارب والشخصيّات، والتوازي في الأمكنة والأزمنة والأصوات، وهدف إلى دراسة الطبيعة الزمنيّة لقصيدة القناع والظواهر الزمنية المتعلّقة بها وتأثيرها على الرؤيا النصيّة والمغزى الكلّي، وأردف المقاربة النظرية بتطبيق على نص (قناع لمجنون ليلى) لمحمود درويش، واتخذ البحث التأويل الفينومينولوجي منهجًا لفهم الزمن في الشعر، فعد الزمن ظاهرة من ظواهر الوعي، وتعامل مع أزمنة النص على أنها أزمنة باطنيّة قائمة في الوعي، وقد وصل البحث إلى أنّ قصيدة القناع مؤسسة على التحوّلات الزمنيّة التي تمكّن من جمع التجارب الزمنيّة للذوات المتفاوتة زمنيًّا، وأن التجارب الزمنيّة في هذه القصيدة تعلّقت بشخصيّة (ليلى) التي اتضح أنّها مصدر زمني يرمز إلى (فلسطين)، وكانت مهمّة القناع الوصول إلى (ليلى/ فلسطين) مسترشداً بوجودها الزمني لكنّه لم ينجح لاختلاف طبيعتها الزمنيّة وتحكّمها في زمنه، وتسبّب ذلك في تصاعد الإشكاليّات الزمنيّة التي عانى منها القناع وتزايد العبء الزمني الذي أدّى إلى سقوطه في نهاية القصيدة، وعلى الرغم من ذلك كشفت القصيدة أن التحوّلات المصاحبة لحب (ليلى/ فلسطين) هي تحوّلات في زمن العشق فقط، وأثبتت في المقابل أن الإشكاليات المتعلقة بظهور العشّاق واختفائهم أو دورانهم حول (ليلى/ فلسطين) هي بسبب التفاوت الزمني. وقد أوصى البحث بعدّ القصيدة تجربة من التجارب الزمانيّة الخاصّة، وأنها الموضوع الزمني العام الذي يضم الأزمنة الموضوعيّة الناشئة فيها، وأوصى أيضًا بفهم التحوّل الزمني بمعنى التردّد الزمني والتجوّل بين الأزمنة والعوالم والشخصيّات، كما أوصى بفهم أزمنة الماضي والحاضر والمستقبل على أنها معان زمنيّة مأخوذة من الاتصال الأصلي للزمن ولا تدل على أزمنة منفصلة.
From Lockdown to Laugh-town: Analyzing Saudi’s Humorous Memes during the COVID-19 Crisis.
Authors: Al Mufarreh Raniah
Published: October 2024

This study delves into the realm of humor found in memes that proliferated across various digital platforms in Saudi Arabia in response to the COVID-19 pandemic. These memes emerged as instrumental means of communication, coping, and adaptation throughout the crisis. The research is driven by the objective of categorizing and comprehending the humor in these memes through a qualitative content analysis. The study adopts the incongruity-resolution (IR) framework to scrutinize 150 Saudi memes. The analysis is centered on incongruity-resolution strategies, the interaction between text and image, and contextual elements that contribute to comprehension. The results reveal that Saudi COVID-19 memes predominantly employ seven incongruity-resolution strategies, both with and without image integration. Notably, a substantial portion of the memes (30.5%) defies categorization within any specific IR class and is hence classified as ‘textless memes.’ These memes effectively convey compelling messages without any textual content, relying on shared experiences. The analysis has yielded valuable insights into the diverse methods employed in constructing humor, resolving incongruities, and the significance of contextual information in generating humorous effects. These findings carry implications for cross-cultural communication, digital media, public health communication, and the exploration of humor within crisis situations. Understanding the role of humor in navigating global crises and its evolutionary dynamics is pivotal for achieving effective communication and adaptation within the rapidly transforming digital landscape.
Nanoscale Study on Noninvasive Prevention of Dental Erosion of Enamel by Silver Diamine Fluoride
Authors: Saha Aditi , Kim Yohan , Kim Kack-Kyun , Kim Young J. , Byon Hye Ryung , Hong Seungbum
Published: October 2024

Here, we aimed to demonstrate the efficacy of silver diamine fluoride (SDF) in halting dental erosion caused by dietary selection and offer a potential explanation for the underlying mechanism. We investigated the surface chemical and mechanical characteristics of human tooth enamel when exposed to Coca-Cola from 10 s to 1 h, with and without the topical treatment of SDF. We analyzed the mechanical properties by measuring the enamel surface roughness and elastic modulus using atomic force microscopy and the surface chemical composition through x-ray photoelectron spectroscopy and Fourier transform infrared spectroscopy analyses, with scanning electron microscopy as a supplementary characterization method. After 1 h of immersion in Coca-Cola, the roughness changed from 83 to 287 nm for enamel without SDF treatment and 64 to 70 nm for enamel with SDF treatment. Under the same conditions, the elastic modulus changed from 125 GPa to 13 GPa for enamel without SDF treatment and 215 GPa to 205 GPa for enamel with SDF treatment. Topical coating of SDF onto enamel formed a passivation layer composed of fluorapatite and created added fluorine flux in the system, which protected the teeth from demineralization under Coca-Cola etching, as shown by morphology and chemical composition analysis as well as roughness and modulus characterization. Applying SDF to enamel minimizes changes in chemical compositions and surface roughness while improving enamel elastic modulus.
The Inhibition of Interfacial Ice Formation and Stress Accumulation with Zwitterionic Betaine and Trehalose for High-Efficiency Skin Cryopreservation
Authors: Liu Xinmeng , Zhang Liming , Li Haoyue , Yang Jing , Zhang Lei
Published: October 2024

Cryopreservation is a promising technique for the long-term storage of skin. However, the formation of ice crystals during cryopreservation unavoidably damages skin structure and functionality. Currently, the lack of thorough and systematic investigation into the internal mechanisms of skin cryoinjury obstructs the advancement of cryopreservation technology. In this study, we identified 3 primary contributors to skin cryoinjury: interfacial ice nucleation, stress accumulation, and thermal stress escalation. We emphasized the paramount role of interfacial ice nucleation in provoking ice growth within the skin during the cooling process. This progress subsequently leads to stress accumulation within the skin. During the rewarming process, the brittleness of skin, previously subjected to freezing, experienced a marked increase in thermal stress due to ice recrystallization. Based on these insights, we developed a novel zwitterionic betaine-based solution formulation designed for cryopreservation skin. This cryoprotective agent formulation exhibited superior capability in lowering ice nucleation temperatures and inhibiting ice formation at interfaces, while also facilitating the growth of smooth and rounded ice crystals compared to sharp-edged and cornered crystals formed in aqueous solutions. As a result, we successfully achieved prolonged cryopreservation of the skin for at least 6 months, while preserving 98.7% of structural integrity and 94.7% of Young’s modulus. This work provides valuable insights into the mechanisms of ice crystal damage during organ cryopreservation and profoundly impacts the field of organ transplantation and regenerative medicine.
Noninvasive Monitoring of Programmed Death-Ligand 2 Expression with Positron Emission Tomography using
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Ga-labeled Peptide Antagonist in Preclinical and Exploratory Human Studies
Authors: Zhao Yajie , Yin Xiaoqin , Zhou Ming , Rao Wanqian , Ji Xuan , Wang Xiaobo , Xiao XiaoXiong , Hu Shuo
Published: October 2024

While the expression of programmed death ligand-1 (PD-L1) is associated with response to immune therapy, PD-L1-negative patients may still benefit from immune treatment. Programmed death ligand-2 (PD-L2), another crucial immune checkpoint molecule interacting with PD-1, correlates with the efficacy of various tumor immune therapies. This study investigates the expression of PD-L2 in non-small cell lung cancer (NSCLC) patients following anti-PD-1 therapy and its predictive value for clinical survival outcomes. Additionally, we explore the noninvasive, real-time, and dynamic quantitative analysis potential of PD-L2 positron emission tomography (PET) imaging in transplanted tumors. We utilized [
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Ga]Ga-labeled peptide HN11-1 for PD-L2 PET imaging. The results indicate a higher response rate to anti-PD-1 therapy in patients positive for both PD-L1 and PD-L2, with PD-L2 status independently predicting progression-free survival (PFS) with pembrolizumab treatment. Furthermore, [
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Ga]Ga-HN11-1 PET imaging demonstrates specificity in assessing PD-L2 status. Overall, we confirm the correlation between high PD-L2 expression and favorable PFS in NSCLC patients post anti-PD-1 therapy and highlight the promising potential of [
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Ga]Ga-HN11-1 as a specific tracer for PD-L2 in preclinical and initial human trials.
AVALIAÇÃO DE CULTIVARES DE ALFACE AMERICANA PRODUZIDAS EM ESTUFA E A CAMPO
Authors: Vieira Júnior Paulo Sérgio Martins , Sousa Letícia Martins de , Teixeira Itamar Rosa , Mota José Hortêncio
Published: October 2024

Este estudo teve por objetivo avaliar o desempenho agronômico de cultivares comerciais de alface do grupo repolhuda crespa (americana) em cultivo estufa e campo nas condições edafoclimáticas de Jataí-GO. O delineamento utilizado foi o de blocos casualizados com três repetições e dez cultivares (Angelina, Aroeira, Bruma, Escarcha, Lucy Brown, Ludmila, Raider, Santa Celeste, Serena, Tainá). As características avaliadas foram massa fresca total e comercial, diâmetro e altura de planta, número de folhas, peso, diâmetro e comprimento de caule. Observou-se que houve efeito para o cultivo no solo e em hidroponia, observou-se que houve efeito significativo das cultivares para massa fresca total e comercial, altura de plantas, peso caule, diâmetro e comprimento de caule. Todas as cultivares avaliadas tanto para o cultivo na hidroponia como no campo apresentaram padrão comercial para o mercado in natura, sendo que as cultivares Ludmila, Santa Celeste, Serena e Tainá apresentaram resultados superiores às demais cultivares para o cultivo em hidroponia. Já para o cultivo em solo a cultivar Ludmila apresentou melhor desempenho para massa fresca comercial. Observou-se que, no cultivo em estufa, houve antecipação na colheita de 44 dias, quando comparado ao cultivo em campo.
Licere 25 Anos
Authors: Mota Andreza Gonsalez Rodrigues , Gomes Vivianne Limeira Azevedo , Pereira Brisa de Assis , Abade Natascha Stephanie Nunes , Santos Rafael Rodrigo dos
Published: October 2024

Este estudo aborda alguns aspectos da trajetória dos 25 anos da Revista Licere, do PPGIEL da UFMG, destacando sua evolução desde a concepção até sua consolidação como referência nos Estudos do Lazer. Utilizando a história oral dos idealizadores e a análise de dados do site da Revista, buscamos examinar, divulgar e preservar a trajetória da Licere, incluindo seu pioneirismo, adaptação à cultura digital e perspectivas futuras. Foram analisadas 1.105 publicações de artigos em diferentes edições da Revista, foi possível acessar todos os artigos de maneira digital, categorizadas por gênero, instituição e além dos eixos temáticos englobados por cada produção. Observamos nas análises que as publicações no campo do lazer evidenciam que as mulheres vêm se destacando, a UFMG foi aquela instituição que mais teve publicações, a temática lazer e sociedade se sobressai nos resultados e a região Sudeste lidera na produtividade. A Revista Licere se avulta com o compromisso contínuo de enriquecimento do conhecimento na área do Lazer.
Influence of trapped magnetic field of Sn-Pb solders on electrical resistivity measurement: an example of superconducting transition of Sn
Authors: Ichikawa Takumi , Watanabe Yuto , Murakami Takumi , Rani Poonam , Yamashita Aichi , Miura Osuke , Mizuguchi Yoshikazu
Published: October 2024

We examined the effect of the flux-trapped states of Sn60-Pb40 solders on the superconducting properties of a Sn wire. The temperature dependence of electrical resistivity at H = 0 Oe after zero-field cooling (ZFC) showed a sharp superconducting transition at T = 3.7 K. In contrast, field cooling (FC) resulted in a broadening of the transition. The difference between ZFC and FC data evidences the critical effect of trapped fluxes at solders on superconducting states. We propose that, in electrical measurements where magnetic fields of several hundred Oe are critical, field experience should be seriously considered when using solders.
Measurement of temporal evolution of antiferromagnetic domain change in nickel oxide driven by 2TO phonon mode excitation via pump-probe experiment
Authors: Bo Ju Yoon Hnin , Zen Heishun , Ohgaki Hideaki
Published: October 2024

The temporal evolution of antiferromagnetic domain pattern changes under resonant excitation of the second-order transverse optical phonon mode in nickel oxide was investigated using mid-infrared free electron laser (MIR-FEL) pulses and visible nanosecond probe laser pulses at room temperature. We visualized the domain patterns through magneto-optical polarized microscopy in transmission and observed their temporal variation after the phonon excitation via MIR-FEL. We evaluated the differences throughout the timeline using the structural similarity index measure technique from domain images with and without MIR-FEL irradiation. We found that the MIR-FEL irradiation induces significant structural changes in the domain patterns. The maximum difference was observed at the timing of the MIR-FEL irradiation and exponentially recovered with the time constant of 1.4 ± 0.2 ms. This rather long-time constant could be owing to the spin relaxation, whilst further investigation is needed to confirm the underlying mechanism.
Self-traceable angle standards with simplified traceability chain for dimensional metrology
Authors: Deng Xiao , Shen Junyu , Xiong Yingfan , Gou Jinming , Tang Zhaohui , Xiao Guangxu , Yin Zhijun , Xue Dongbai , Shi Yushu , Shi Zhoumiao , Xie Yuying , Cheng Xinbin , Li Tongbao
Published: October 2024

Traceability is a fundamental issue for ensuring accuracy of nanometrology. A shortened traceability chain is advantageous for reducing calibration steps, thus reducing errors and raising application efficiency. A novel kind of two-dimensional grating is manufactured by atom lithography, whose pitch and (orthogonal) angle values are directly determined by natural constants, offering a feasible approach for effectively shortening the traceability chain. The PTB’s calibration results show that the two-dimensional grating has excellent orthogonality with a deviation of only 0.001°. The application of two-dimensional grating is demonstrated for the characterization of the angular distortion of a SEM, showing its great application potential.
A STUDY OF EFFICACY OF ONDANSETRON AND GRANISETRON IN PREVENTING POST-OPERATIVE SHIVERING IN PATIENTS RECEIVING GENERAL ANAESTHESIA
Authors: R. Fating Dnyaneshwar , Kulkarni Vaishnavi , Khar Syiemlieh Teilang
Published: October 2024

Introduction: Post-operative shivering is a very unpleasant nding after general anesthesia. It is distressing to patients
especially with ischemic heart diseases as shivering increases oxygen consumption. 5-HT3 receptor blockers are
routinely given as a premedication to patients receiving general anesthesia as an anti-emetic. The 5-HT3 receptors blockers have antishivering
property as well and their efcacy as an antishivering agent is studied here. 80 patients were inclu Methods: ded in the study with 40 patients in
each group. Group G received intravenous granisetron and Group O received intravenous ondansetron along with other drugs as premedication.
The study was conducted in patients undergoing laparoscopic appendicectomy and laparoscopic cholecystectomy. Keeping all the Results:
parameters like demography and duration of surgery comparable in both the groups, The total patients who had shivering post-operatively in
Group G were 3 (7.5%) and in Group O were 10(25%) with a signicant p value. Granisetron is better Conclusion: than Ondansetron in
preventing post-operative shivering in the anti-emetic doses administered preoperatively, without affecting the hemodynamic state of the
patients.
INDIAN DIABETIC RISK SCORE AS A SCREENING TOOL FOR UNDIAGNOSED DIABETES IN ADULT POPULATION IN PUDUCHERRY.
Authors: V Saranya , S P Kasipandian , K Suresh.
Published: October 2024

Background Diabetes is a major public health problem. Diabetes also exhibits an iceberg phenomenon where majority of
the cases were hidden in the community as undiagnosed ones. To identify the high-risk subjects for s Objectives creening
of undiagnosed diabetes mellitus using IDRS and evaluating the IDRS as a screening tool. The present Material and Methods study was cross
sectional study carried out among adults more than 18 years in the department of general medicine for a period of 3 months. The sample size was
estimated to 135. Those who were already diagnosed to have diabetes and unwilling to participate were excluded from the study. The data was
collected in a semi structured questionnaire. Statistical analysis was done using descriptive statistics. The mean IDRS score among the Results
participants was 56.29 ± 18.71. 54 (40%) were having a score between 50 and 60. 44 (32.6%) were having score between 70 and 80. Among the
participants with IDRS score of more than or equal to 60, 27 (36%) were diabetic and among those with IDRS score of less than 60, none was
diabetic. The sensitivity was 100%, specicity was 55.6%, the positive predictive value was 36%, the negative predictive value was 100%. The
accuracy of IDRS was found to be 64.4% The IDRS is a valid screening tool among the population undi Conclusion agnosed with diabetes
mellitus.
RISK ASSESSMENT IN ACS USING GRACE SCORE
Authors: Singh Surendra , Sarawag Mayank , Agarwal Manogya , Rahar Monika
Published: October 2024

Importance: Cardiovascular diseases are the leading global cause of death, projected by WHO to account for 33% of
deaths by 2030, driven by lifestyle changes and rising rates in countries like India. Despite advances in treating acute
myocardial infarction, mortality remains high, highlighting the need for effective risk assessment tools like the GRACE score, which is valued
for its comprehensive, accessible, and validated risk prediction. To evaluate the risk of acute coro Objective: nary syndrome (ACS) using the
GRACE risk score to predict in-hospital mortality and identify associated risk factors. This observa Design: tional cross-sectional study was
conducted from February to December 2022. This study was conducted in a tertiary care medical Centre Setting: - SRG hospital and Jhalawar
Medical College, Jhalawar, India. 200 ACS patients having rst incidence of acute coronary syndrome Participants: were selected by
convenience sampling after obtaining their written informed consent. Patients were excluded if they had a known diagnosis of coronary artery
disease (CAD), declined to provide consent, or were discharged before their data could be fully collected. The exposures Exposure(s):
examined in the study included age, family history of ACS, smoking, dyslipidemia, and obesity. Main Outcome(s) and Measure(s): The study
aimed to predict in-hospital mortality in ACS patients using the GRACE risk score, which demonstrated excellent discrimination. All fatalities
were associated with high GRACE risk scores. Out of 200 patients, 150 (75%) were male and 50 (25%) w Results: ere female, with a mean age of
59.45 ±12.56 years. Fourteen patients (7%) died during hospital stay. The GRACE risk score had 100% sensitivity and high specicity (85.42%
for NON-ST-Elevation ACS, 70% for ST-Elevation Myocardial Infarction) for predicting mortality. Its negative predictive value was 100%, and
the positive predictive value was 25% for STEMI and 22.22% for NON-ST-Elevation ACS. The GRACE score showed excellent discrimination
with a C-statistic of 0.99 and a 95% condence interval of 115.742 – 151.221 (p<0.001). Elevated heart rate, low blood pressure, high serum
creatinine, and Killip class 4 were signicantly associated with in-hospital mortality (p<0.001). th Conclusions and Relevance: is study
demonstrates that the GRACE Risk Score is highly effective in predicting in-hospital mortality among patients with Acute Coronary Syndrome.
Its accuracy in assessing risk underscores its utility as a crucial tool for identifying high-risk patients.
CT IMAGING IN EMPHYSEMATOUS PYELONEPHRITIS: KEY FINDINGS AND CLINICAL IMPLICATIONS
Authors: Akshaj Aila , Sadagana Abhinaya
Published: October 2024

Emphysematous pyelonephritis (EPN) can be dened as an acute necrotizing infection of the renal parenchyma and
surrounding tissues. Diabetes mellitus is the most important risk factor, presenting in >90% of the cases. Escherichia coli
(E.Coli) is the most common organism cultured from urine and blood specimens. The symptoms of EPN infection are usually nonspecic, but the
clinical triad of fever, ank pain, and nausea are the most common presentations. Clinical diagnosis of the condition closely mirrors acute
pyelonephritis, which requires accurate evaluation through imaging, particularly computed tomography (CT) scans.
A RARE CASE REPORT: OVERLAP SYNDROME OF SYSTEMIC LUPUS ERYTHEMATOSUS AND SJOGREN SYNDROME AT TERTIARY CARE CENTER
Authors: Kushwah Amrendra Singh , Kanodia Nishant , Prasad Verma Durga , Lagarkha Nishant
Published: October 2024

Introduction- Overlap syndrome (OS) is dened as an entity that satises the classication criteria for at least two
connective tissue diseases (CTDs) occurring at the same time or at different times in the same patient We are Casepresenting a case report of 35 years old female presented with complain of recurrent oral ulcers , multiple joint pain, rash over the face since 3
months diagnosed with Overlap syndrome of SLE and Sjogren Syndrome based on clinical symptoms and laboratory investigations. Discussionpatient presented with classical features of Systemic Lupus Erythematosus along with Sjogren syndrome symptoms for long time and repeated
hospitalization in past should be evaluate with blood investigations to rule out causes of Overlap Syndrome in middle aged woman.
Simulating farm structural change dynamics in Thessaly (Greece) using a recursive programming model
Authors: Mantziaris Stamatis , Rozakis Stelios , Karanikolas Pavlos , Petsakos Athanasios , Tsiboukas Konstantinos
Published: October 2024

Although the policy impacts on farms accumulate year by year, most farm decision models focus on short-term decisions, evaluating policies based on snapshots. Structural changes are gradually built; therefore, farm decision models should consider the sequences within the period under study. Multiyear data from the arable sector in Thessaly, Greece, have fed a newly developed farm-level recursive linear programming model mainly to simulate farm structural change dynamics. The proposed model incorporates new evidence on the strategic decision of arable crop farms regarding their remaining in the production system and farm expansion. Results reveal an evident gradual farmland concentration in relatively large farms, accompanied by a gradual expansion of the most profitable cropping activities, verifying the real-world survival strategy of farms.
Crop production, the pollinator deficit and land use management: UK farm level survey results
Authors: Fraser Iain , Fountain Michelle T. , Holland John M.
Published: October 2024

In this paper, we address a gap in the literature concerning pollination management, the pollinator deficit, and conservation objectives. By employing a farm level survey of UK farmers, we examine farmers’ attitudes, understanding and management of pollinators. Based on descriptive statistics and regression analysis, we found significant variation in interest and understanding of the impact of pollinators on commercial crops meaning that many respondents did not consider they had a pollinator deficit in terms of crop quality, quantity, or financial impacts. At the same time, many farmers are willing to adopt environmentally beneficial land-use measures if suitable advice and financial incentives are offered. However, there is little evidence of coordination of actions between farms to support wild pollinators. These findings indicate a potential disconnect between a farmer’s understanding of the impact on agricultural output from a pollinator deficit and the agricultural benefits from the adoption of specific environmental measures.
Farm characteristics and exogenous factors influencing the choice to buy land in Italy
Authors: Russo Silvia , Raggi Meri , Bimbati Barbara , Povellato Andrea , Viaggi Davide
Published: October 2024

Access to land is one of the key factors of farm growth, while at the same time, related research is characterised by important gaps, in particular facing the change over time in the nature and role of drivers of the land market. The objective of this research is to identify the endogenous and exogenous factors that affect the decision to purchase land in Italy between 2013 and 2020. Five probit regression models were implemented to understand the role of a set of different determinants in land investment decisions. The results show that factors related to capital in machinery and equipment, energy production and the presence of a successor are endogenous factors that positively influence the purchase decision. The ratio of rented land to utilised agricultural area and of family work units to total work units are endogenic factors that negatively influence the purchase decision. Exogenous factors related to the cost of capital and inflation rate affect the purchase of land in an opposite way, negatively and positively respectively. The role of Utilised Agricultural Area and Gross Saleable Production per hectare varies depending on the specialisation considered. The research can support policymakers in designing policies to promote the survival and growth of farms, as well as to facilitate land investment by reducing barriers to land acquisition.
Educación bioeconómica: Una red biosemiótica de conexiones entre sociedad y naturaleza en un contexto complejo
Authors:   Universidad de San Carlos de Guatemala, Orellana Aldana Oscar Eduardo
Published: October 2024

Los procesos cognitivos en el ser humano tienen una intrincada relación con su entorno; de alguna forma la capacidad que se tiene para absorber el conocimiento es un proceso recursivo, el ambiente alimenta al ser humano y este alimenta al ambiente recursivamente; en este sentido, lo que se percibe de la sociedad, es así mismo un reflejo de lo que la misma proyecta. De alguna manera, incluso, existen estudios sobre epigenética que indican que el ADN está expuesto a cambios mediante el ambiente y que estos cambios pueden incluso trasladarse a los descendientes y que una buena parte de esa herencia tienen que ver con procesos cognitivos.
Hacia una convivencia armoniosa entre sociedad y naturaleza
Authors:   Universidad de San Carlos de Guatemala, Orellana Aldana Oscar Eduardo
Published: October 2024

La bioeconomía se destaca como una ciencia transdisciplinar que forma parte integral de las ciencias de la complejidad o ciencias de la vida, debido a que esta entrelaza los conceptos de desarrollo económico, la sustentabilidad y sostenibilidad ecológica, además, incorpora en su estudio el bienestar social. Para Gaviria et al. (2021, como se citó en Carrizosa et al., 2023) es fundamental destacar que no es un modelo económico; sino que es "un proceso disruptivo con profundos impactos sociales, ambientales y económicos, fundamentado en el uso intensivo del conocimiento para abordar retos globales" (p. 90). Esta definición resalta la naturaleza de la bioeconomía como un campo emergente, impulsado por la innovación y el conocimiento, enfocado en la solución de desafíos contemporáneos.
Recursividad y emergencia: Educación y empresa como sistemas dinámicos, interdependientes y simbióticos
Authors:   Universidad de San Carlos de Guatemala, Pérez Yoc Adery Luciano
Published: October 2024

Los seres humanos viven en agrupaciones conocidas como sociedades. Originalmente, sus necesidades básicas eran alimentarse y buscar refugio, lo que hoy llamamos vivienda. Con el tiempo, el Desarrollo de estas sociedades ha generado nuevas "necesidades", que en realidad son deseos impuestos por la propia sociedad, un fenómeno que Fromm (2006) asocia con el concepto de "tener".
Pneumococcal Septicemia: A Neonatal Case Report
Authors: Daraoui Z. , Lalaoui A. , Tahiri F. , Bennaoui F. , Slitine N. El Idrissi , Soraa N. , Maoulainine F. M. R.
Published: October 2024

Pneumococcus or Streptococcus pneumoniae is a rare cause of neonatal sepsis, associated with significant morbidity and a very high mortality rate. The infection is generally acquired during pregnancy, from colonization of the maternal genital tract. Most affected newborns present with early symptoms, usually within 48 hours of birth, which is similar to other causes of neonatal sepsis. We report the case of a premature female neonate with fatal, early pneumococcal sepsis that appeared at D1 of life, with an unfavorable course that initially led to intubation and death after 24 hours of hospitalization.
Benign Cystic Mesothelioma of the Uterus: Myth or Reality?
Authors: Bergaoui Haifa , Mnejja Amina , Ghaddab Imen , Hajji Ahmed , Hafsi Montacer , Mtir Hela , Farhat Imen Ben , Najjar Sana Bouakez Héla , Zoukar Olfa , Toumi Dhekra , Faleh Raja
Published: October 2024

Mesothelioma is a very rare tumor of mesodermal origin that covers the surface of body organs such as the peritoneum, pleura and pericardium. This tumour in the majority of cases presents in its malignant form where it represents some characteristics: increased cellularity, cytological atypia, papillary formations, even invasion. We report the case of Mrs AB, 37 years old, blood group A positive with no particular pathological history, nulli gesture nulli pare, consulted for pelvic pain and abdominal bloating. The clinical examination showed a distended bloated abdomen with a 20 centimetre pelvic mass with regular contours and painlessness. Abdominal and pelvic ultrasound showed a globular uterus increased in size by 200 millimetres with a multilocular cystic image intra myometrial (corporal anterior and fundial) of 188*79 millimetres. Intraoperatively, a globular uterus was found to be enlarged with a 15 centimetre parovascular cystic mass, dependent on the anterior aspect of the uterus, with a rock water fluid content, without any other associated abnormalities The postoperative course was simple. To conclude, Benign cystic mesothelioma of the uterus is a tumour of diagnostic value. This tumour is spleen. The preoperative evaluation allows the diagnosis to be suspected, especially by pelvic magnetic resonance imaging.
Association of C- Reactive Protein and Glycated Hemoglobin among Type 2 Diabetic Adults
Authors: Jahan Nasrin , Firoz Abu Md. Ahsan , Nowroz A S M , Islam Md Saiful , Mortaz Rubaiyat-E- , Shafiq Sabrina , Zaman Khan Md. Shahariar , Rahman A. K. M Shahidur
Published: October 2024

Background: Diabetes mellitus (DM) is a complex metabolic disorder and is a major global health problem. An increasing amount of evidence suggests that chronic subclinical inflammation is one of the triggering factors in the onset of type 2 diabetes mellitus (T2DM). Objective: The current study was designed to determine the association of C- reactive protein (CRP) and glycated hemoglobin (HbA1c) in T2DM patients. Methods: This cross-sectional study was carried out at Department of Laboratory Medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh between March 2017 to February 2018. Total 80 adult patients of newly diagnosed T2DM were included in this study. A detailed clinical history was recorded and relevant physical examinations were done. The complete blood count (CBC), C-reactive protein (CRP), fasting blood glucose (FBG) and HbA1c were done accordingly. Data were analyzed and compared by statistical tests. Results: The mean age of the study patients was 45.06±11.08 years with female predominance. More than half (53.7%) of the study patients were in age group 41-59 years. Majority (65%) of the study patients was overweight/obese. It was observed that, mean(±SD) FBG, HbA1c and CRP levels were 8.97±2.41 mmol/L 8.54±2.08% and 8.98±4.85 mg/L respectively. Pearson correlation analysis revealed that CRP has a significant positive correlation with HbA1c (r= 0.457, p< 0.001). Conclusion: This study concluded that CRP has a significant positive association with HbA1c in adult T2DM patients. CRP can be used as a valuable and effective tool for monitoring T2DM.
Situación de la pesca artesanal en Galicia y retos ecosistémicos para una nueva agenda de cambio social transformador
Authors: Seijo Villamizar Javier , Martín Bermúdez Federico
Published: October 2024

Este análisis trata sobre las razones de cambio social en el actual modelo de gobernanza de la pesca artesanal en Galicia. Con este objetivo, se ilustran los atributos emergentes y conductores que acompañan al oficio de pescador/a y mariscador/a en los ecosistemas asociados a la flota del Cantábrico-Noroeste. El método de estudio se articula mediante un análisis descriptivo de información clave desde estudios empíricos y teóricos. La metodología presenta una caracterización y retos para las cofradías de Galicia. En síntesis, se reflexiona sobre cuál es el mejor camino para una nueva agenda de cambio social en Galicia desde la gobernanza marina y el paradigma de gobierno abierto, para la innovación social y democrática.
Macrolide and fluoroquinolone resistance in Mycoplasma genitalium isolated from pregnant women in Russia and Belarus
Authors: Avchinnikova D.A. , Edelstein I.A. , Pokusaeva V.N. , Rudneva N.S. , Sukhanova L.N. , Akhmedova A.M. , Madzharova O.A. , Lapuka M.O. , Romanov A.V.
Published: October 2024

Objective.
To study epidemiology of resistance to macrolides and fluoroquinolones in Mycoplasmagenitalium isolated from pregnant women in Russia and Belarus.

Materials and Methods.
A total of 107 M. genitalium DNA samples isolated from pregnant women in Russia (n = 58) and Belarus (n = 49) was included in the study. In order to detect markers of macrolide or fluoroquinolone resistance, polymerase chain reaction in real time with the effect of quenching fluorescence of the probe by a primer was used. Confirmation of mutation type was performed using Sanger sequencing.

Results.
The prevalence of M. genitalium resistance mutations to macrolides in Russia (Tula, Smolensk) and Belarus (Vitebsk, Brest, Minsk) was 3.4% (2⁄58) and 6.1% (3⁄49), respectively. Markers of M. genitalium resistance to fluoroquinolones were detected in 5.2% (3⁄58) of samples from Russia and 8.2% (4⁄49) of samples from Belarus. The most common mutations associated with macrolide resistance were A2059G (n = 4), fluoroquinolone resistance – D84N (n = 3) and S80I (n = 3) (numbering according to E. coli).

Conclusions.
The prevalence of M. genitalium resistance markers isolated in pregnant women highlights a need for regular macrolide and fluoroquinolone resistance surveillance.
PENGARUH MULTIMEDIA PEMBELAJARAN UNTUK MENINGKATKAN HASIL BELAJAR SEPAK BOLA MAHASISWA FIKK UNESA
Authors: Mochamad Ridwan  , Dwi Lorry Juniarisca  , Irma Febriyanti  , Fajar Eka Samudra  , Made Pramono
Published: October 2024

Multimedia memiliki peran untuk meningkatkan hasil belajar sepakbola yang meliputi aspek pengetahuan maupun keterampilan. Penting bagi dosen untuk menerapkannya agar pembelajaran menjadi lebih variasi dan bermakna sehingga tidak menimbulkan kejenuhan. Tujuan dari penelitian ini yaitu untuk mengetahui pengaruh multimedia pembelajaran untuk meningkatkan hasil belajar sepakbola. Metode penelitian yang digunakan oleh penulis yaitu kuantitatif dalam bentuk eksperimen semu dengan desain penelitian menggunakan one group pretest-posttest. Sampel ini sebanyak 87 mahasiswa dengan penelitian dilakukan selama 4 pertemuan. Teknik pengumpulan data yang digunakan yaitu instrumen tes hasil belajar pengetahuan dan keterampilan. Teknik analisis yang digunakan yaitu uji t dengan taraf signifikan < 0,05. Hasil penelitian menunjukkan bahwa dengan pemanfaatan multimedia mampu memudahkan mahasiswa dalam menerima materi, waktu belajar menjadi fleksibel, tidak terbatas ruang dan akses yang cepat. Oleh karena itu, dapat simpulkan bahwa terdapat pengaruh yang signifikan multimedia pembelajaran dalam meningkatkan hasil belajar sepak bola mahasiswa FIKK Unesa. Diharapakan dosen dalam melaksanakan perkuliahan hendaknya menggunakan multimedia pembelajaran agar mahasiswa lebih semangat dan senang sehingga menimbulkan hasil belajar yang diharapkan.
EFEKTIVITAS HUBUNGAN PELATIH DAN ATLET DALAM PEMBENTUKAN KETANGGUHAN MENTAL UKM FUTSAL UNIVERSITAS PENDIDIKAN INDONESIA
Authors: Try Utama Pasca Nugraha  , Nurlan Kusmaedi  , Ahmad Hamidi
Published: October 2024

Ketangguhan mental menjadi suatu komponen yang sangat penting untuk perkembangan atlet selain kemampuan teknik dan fisik yang dimiliki. Pelatih pun menjadi faktor yang sangat penting terhadap peran pembentukan ketangguhan mental atlet. Pelatih mempunyai tanggung jawab membimbing  dalam membangun ketangguhan mental atlet di lapangan maupun di luar lapangan. Tujuan dari penelitian ini untuk mengetahui seberapa besar ketangguhan mental dan seberapa besar kontribusi hubungan pelatih dan atlet terhadap pengembangan ketangguhan mental. Jenis penelitian ini deskriptif kuantitatif, populasi dalam penelitian ini adalah atlet UKM Futsal Universitas Pendidikan Indonesia berjumlah 35 orang atlet. Teknik sampling yaitu total sampling. Kriteria sampling: (1) Atlet Futsal UKM Universitas Pendidikan Indonesia, (2) Mengisi instrumen yang diberikan peneliti secara penuh. Instrumen yang digunakan dalam penelitian ini yaitu Mental Toughness Questionnaire (MTQ) dan Coach-Atlet Relationship (CART-Q). Teknik Analisa data yang digunakan yaitu Uji Korelasi Pearson. (1) Hasil penelitian menunjukkan, ketangguhan mental atlet UKM Futsal Universitas Pendidikan Indonesia berada pada klasifikasi tangguh yaitu pada angka 30,66, Kategori nilai 28,01-42,00. (2) Tidak terdapat kontribusi yang signifikan hubungan pelatih dan atlet dalam pembentukan ketangguhan mental. Banyak faktor yang dapat berpengaruh terhadap ketangguhan mental, faktor sosial seperti rekanan atlet dan keluarga, tidak hanya itu faktor mindset yang diterapkan pun juga berpengaruh sangat terhadap pembentukan ketangguhan mental. Kesimpulannya adalah hasil penelitian menunjukkan ketangguhan mental berada pada tingkat tangguh yaitu sebesar 30,66, serta hubungan pelatih dan atlet memiliki kontribusi yang lemah terhadap pengembangan ketangguhan mental.