bluuebunny/crossref_metadata_2025 huggingface dataset:
Is marketing digitization important?
Authors: Suasana I Gst. A. Kt. Gd. , Warmika I Gde Ketut , Ekawati Ni Wayan , Rastini Ni Made
Published: April 2022

Small industries tend to achieve marketing performance harder than their bigger counterparts, constrained by limited resources when compared to large businesses, especially during the Covid-19 pandemic. These constraints seem to still be relatively difficult to find a way out and result in low marketing performance including small industries in Denpasar. The purpose of the study is to explain the influence of entrepreneurial personality on marketing performance and to investigate the role of digitalization of marketing as a moderation of the influence of entrepreneurial personality on the marketing performance of small industries in Denpasar. The subject of the study was a small industry in Denpasar, represented by the owner / manager as a source. The sample size was set at 150 respondents. Analysis techniques use Moderated Regression Analysis (MRA). The results found that entrepreneurial personality has a significant influence on marketing performance, and digitalization of marketing acts as a quasi-moderation of the influence of entrepreneurial personality on the marketing performance. Small industries should be more active in exploring paid online media since it has a wider reach, such as existing market places or utilizing government-provided facilities, be careful about setting production targets and setting targets for special forces on marketing performance.
Influence of people, processes and technology on business strategy in small enterprise in a Covid 19 environment
Authors: Inga-Ávila Miguel , Churampi-Cangalaya Roberto , Inga-Aliaga Miguel , Rodríguez-Giraldez Wiliam , Vicente-Ramos Wagner
Published: April 2022

The business context has been affected by the action of Covid 19, and companies must react to this new reality. The research analyzes people, processes and technology and their effect on the development of the respective business strategy in small companies in Huancayo, Peru. The study design was non-probabilistic, cross-sectional, qualitative-quantitative and explanatory in a sample of 99 business units. The analytical technique used was structural equation modeling based on PLS. The results indicate that there is a positive relationship between the processes and technology used and the implementation of actions to achieve their objectives. No significant relationship was found with people, given that in the face of the health emergency, economic paralysis, closure of markets and sectors, the companies had to make decisions and postpone concern for human resources. The coefficient of determination (R2) was 79.3%, which shows that the model presented allows predicting future results.
Information diffusion model with homogeneous continuous time Markov chain on Indonesian Twitter users
Authors: Firdaniza Firdaniza , Ruchjana Budi Nurani , Chaerani Diah , Radiant Jaziar
Published: April 2022

In this paper, a homogeneous continuous time Markov chain (CTMC) is used to model information diffusion or dissemination, also to determine influencers on Twitter dynamically. The tweeting process can be modeled with a homogeneous CTMC since the properties of Markov chains are fulfilled. In this case, the tweets that are received by followers only depend on the tweets from the previous followers. Knowledge Discovery in Database (KDD) in Data Mining is used to be research methodology including pre-processing, data mining process using homogeneous CTMC, and post-processing to get the influencers using visualization that predicts the number of affected users. We assume the number of affected users follows a logarithmic function. Our study examines the Indonesian Twitter data users with tweets about covid19 vaccination resulted in dynamic influencer rankings over time. From these results, it can also be seen that the users with the highest number of followers are not necessarily the top influencer.
A Study of some Morphological and Essential Oil Characteristics of Spartium junecum L.
Authors: Mahfoud Rahaf , Salame Rim
Published: April 2022

Spartium junecum L. was collected from Baksa in Lattakia, Syria, and studied morphologically depending on characteristics of plant life-form, flowers, leaves, fruits and seeds according to specialized floras, in addition to some characteristics of stomata types, trichomes, pollen grains and fibers that have been demonstrated by this study. The study of the leaves stomata confirmed the presence of 4 types, namely; anisocytic, isotricytic, brachyparahexacytic, and tetracytic. The type of trichomes was the same in all the studied areas, which is: non-glandular trichomes with different densities. Pollen grains were, tricolpate, triangular, the dimensions of the polar axis and equatorial axis were (35µm), and (31µm), respectively. Spartium junecum L. cellulose fibers were extracted by DiCoDe method (digestion–compression–decompression). The morphology of the obtained fibers was studied by optical microscopy (OM). The results showed that Spartium junecum L. fibers are elementary fibers arranged in bundles. The diameter of a single elementary fiber ranged from 7 to 10μm approximately, while the diameter of the whole bundle was about (50μm). The cross-sections showed an irregular polygonal shape with a very much characterized lumen. The essential oil isolated by hydrodistillation from the dried flowers of Spartium junceum L. was investigated by Gas Chromatography-Mass spectrometry (GC/MS) method. The GC/MS analysis of the oil revealed the presence of 6 constituents, of which heptacosene (28.75%), 3-ethyl-5-(2-ethylbutyl)-octadecane (22.45%), heptacosane (21.2%) and heneicosane (18.82%) were the major compounds constituting altogether almost 91.22% of the total composition.
Membranous web in aqueduct of sylvius on FIESTA-C and 3D-BRAVO MR sequence in an adult
Authors:   Department of Radiodiagnosis, Indira Gandhi Institute of Medical Sciences, Patna, India., Sinha Neetu , Gupta Ruchi ,   Department of Radiodiagnosis, Indira Gandhi Institute of Medical Sciences, Patna, India., Vaibhav Waghmare ,   Department of Radiodiagnosis, Indira Gandhi Institute of Medical Sciences, Patna, India.
Published: April 2022

We present a case of 38-year-old man who presented with persisted mild headache and occasional vision loss for four and half years. MRI of brain revealed tri-ventricular dilatation with uninvolved fourth ventricle. On the FIESTA-C and 3D-BRAVO MR sequences, two thin membranous webs were seen in the distal part of the aqueduct of sylvius. At present, the FIESTA sequence is the preferred imaging method for the aqueduct web/diaphragm, but both FIESTA and 3DBRAVO can show the web in aqueduct as well.
Anaesthetic management of fetal congenital diaphragmatic hernia by EXIT: A case report
Authors:   Department of Anesthesiology, Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University, Shenzhen, Guangdong, China., Liang Xiaoli , Liu Danyong ,   Department of Anesthesiology, Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University, Shenzhen, Guangdong, China., Gao Yajing ,   Department of Anesthesiology, Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University, Shenzhen, Guangdong, China., Xiao Yuci ,   Department of Anesthesiology, Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University, Shenzhen, Guangdong, China., Huang Xiaolei ,   Department of Anesthesiology, Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University, Shenzhen, Guangdong, China., Li Yuantao ,   Department of Anesthesiology, Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University, Shenzhen, Guangdong, China.
Published: April 2022

We present a case of congenital diaphragmatic hernia (CDH) diagnosed in the second trimester of pregnancy, with most of the stomach and part of the liver occupying half of the left hemithorax. Severe pulmonary hypoplasia is associated with reduced survival in patients with CDH. The pregnant woman was treated with Exutero intrapartum treatment (EXIT) at 38 weeks of gestation. Open fetal and EXIT procedures require maternal general anesthesia with volatile anesthetic and other medications to maintain uterine relaxation. Through this case, our team summarized some experience in perioperative period anesthetic management of EXIT. Keywords: CDH; EXIT procedure; fetal surgery; maternal anaesthesia.
Acute pancreatitis associated with gangrenous cholecystitis in the absence of definitive laboratory or imaging evidence: Case report and literature review
Authors:   Department of Integrative Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China., Kang Hongxin , Su Hang ,   Health Management Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China., Wan Meihua ,   Department of Integrative Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
Published: April 2022

Gangrenous cholecystitis (GC) is the most severe form of cholecystitis and is associated with acute pancreatitis. Once GC diagnosis is established, urgent cholecystectomy is recommended. The preoperative diagnosis is challenging, and clinical judgment can be critical. We report a case of GC with acute pancreatitis diagnosed in the absence of definite laboratory or imaging evidence. Keywords: gangrenous cholecystitis; acute pancreatitis; diagnosis; clinical judgment. Abbreviations: GC: Gangrenous cholecystitis; CT: computed tomography
Role of global longitude strain related miRNAs as potential prognostic indicators in myocardial infarction
Authors:   Department of Ultrasound, People’s Hospital of Longhua Shenzhen, Shenzhen 518109, Guangdong, China., Chen Xiaozhu , Huang Fengrong ,   Department of Cardiology, People’s Hospital of Longhua Shenzhen, Shenzhen 518109, Guangdong, China., Liu Yunhong ,   Clinical Laboratory, People’s Hospital of Longhua Shenzhen, Shenzhen 518109, Guangdong, China., Liu Shujun ,   Department of Ultrasound, People’s Hospital of Longhua Shenzhen, Shenzhen 518109, Guangdong, China., Ta Gangwen ,   Department of Cardiology, People’s Hospital of Longhua Shenzhen, Shenzhen 518109, Guangdong, China.
Published: April 2022

Background: Real-time three-dimensional spot tracking echocardiography (RT3D-STE) can be used to assess the prognosis of myocardial infarction (MI). Analyzing the correlation between miRNAs and RT3D-STE, especially miRNAs and Global Longitude Strain (GLS) and Global Circumferential Strain (GCS), can provide new ideas for discovering and evaluating the role of miRNAs in assessing myocardial function and prognosis of MI. Methods: The present study collected forty-nine (49) plasma samples (15 normal samples and 34 MI samples; 22 before and 12 after intervention therapy) and employed high-throughput sequencing technology and real-time quantitative polymerase chain reaction (qRT–PCR) to identify the differentially expressed miRNAs. The Pearson correlation coefficient was used to measure the strength of a linear association between differentially expressed miRNAs and strain parameters of RT3D-STE. Results: One hundred forty-one (141) differentially expressed plasma exosome miRNAs were identified in STEMI compared with NSTEMI. The target genes of these ten miRNAs were analyzed for Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment, and they were found to be involved mainly in cellular metabolism processes, HIF-1 signaling pathway, and the FoxO signaling pathway. Moreover, three of these differentially expressed miRNAs (hsa-miR-4798-3p, hsa-miR-371a-3p and hsa-miR4735-5p) had Pearson correlations greater than 0.5 based on GLS. Conclusion: Differentially expressed miRNAs obtained before and after surgical therapy of MI may play important roles in the occurrence and development of MI. hsa-miR-4798-3p, hsa-miR371a-3p, and hsa-miR-4735-5p may be used as potential prognostic indicators of MI. Keywords: surgical therapy; myocardial infarction; real-time threedimensional spot tracking echocardiography (RT3D-STE); differential expression microRNAs; exosomes.
Rare oncological metastasis; Colorectal and male breast cancer
Authors:   The Legacy Heritage Oncology Center & Dr. Larry Norton Institute, Soroka Medical Center & Ben-Gurion University, Beer-Sheva, Israel., Shalata Walid , Golosky Mitchell ,   Medical School for International Health and Sciences, Ben-Gurion University, Beer-Sheva, Israel., Man Sofia ,   The Legacy Heritage Oncology Center & Dr. Larry Norton Institute, Soroka Medical Center & Ben-Gurion University, Beer-Sheva, Israel., Abu-Saleh Omar ,   The Legacy Heritage Oncology Center & Dr. Larry Norton Institute, Soroka Medical Center & Ben-Gurion University, Beer-Sheva, Israel., Khalaila Yusuf ,   Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel., Haj Mohamed ,   Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel., Yakobson Alexander ,   The Legacy Heritage Oncology Center & Dr. Larry Norton Institute, Soroka Medical Center & Ben-Gurion University, Beer-Sheva, Israel.
Published: April 2022

In this report, we describe three cases of rare oncologic metastases. The first patient was a 73-year-old male, diagnosed with metastatic male breast cancer after radiological investigation of suspected renal cell carcinoma. The other two male patients, a 69 and 73-yearold, were diagnosed with colon adenocarcinoma; suspected to be a second primary prostate carcinoma following Positron Emission Tomography-Computer Tomography (PET-CT). This suspicion was ruled out by prostatectomy and histopathological investigations, which instead found adenocarcinoma of colonic origin. Keywords: rare metastasis; colon cancer; male breast cancer; second primary; adenocarcinoma
A case report of neuromyotonia (Isaacs syndrome)
Authors:   Department of Neurology, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China., Sun Xiaojia , Sun Liguo ,   Department of Neurology, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China., Wang Xu ,   Department of Neurology, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China., Feng Honglin ,   Department of Neurology, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Published: April 2022

A 58-year-old man presented with numbness and muscle twitching in the lower limbs since 2.5 months and muscle twitching in the upper limbs since 2 days. In early April 2015, the patient noticed numbness and coolness in the toes of both his feet without any obvious cause, and occasional muscle twitching in the left calf. He developed pain in both calves and twitching in the left thigh; and the muscle twitching gradually worsened in May. On June 9, he experienced muscle twitching in the upper extremities. He had a normal diet with increased sweating, chills, poor sleep, and a weight loss of 15 kg in 2 months.
Extended spinal dysraphism: Rachischisis or myeloschisis
Authors:   Radiology Department, Ibn Sina Paediatric Teaching Hospital, Mohammed V University, Rabat, Morocco, Rita Oze Koudouhonon , Tessi Romeo Thierry Yehouenou ,   Radiology Department, Ibn Sina Paediatric Teaching Hospital, Mohammed V University, Rabat, Morocco, Siham El Haddad ,   Radiology Department, Ibn Sina Paediatric Teaching Hospital, Mohammed V University, Rabat, Morocco, Nazik Allali ,   Radiology Department, Ibn Sina Paediatric Teaching Hospital, Mohammed V University, Rabat, Morocco, Latifa Chat ,   Radiology Department, Ibn Sina Paediatric Teaching Hospital, Mohammed V University, Rabat, Morocco
Published: April 2022

Myeloschisis (rachischisis) is a rare congenital malformation linked to incomplete development of the spine and characterized by posterior opening of the vertebrae [1,2]. It is spread over more than one floor or even the entire spine and incompatible with life. Its diagnosis is clinical, confirmed by ultrasound and cross-sectional imaging [2]. This anomaly in its thoracic location is rare. There are two types: Segmentation and development defects [4]. Developmental defects include hemi vertebrae and failure of neural tube fusion which in turn includes the simple cleft of the posterior arch of the vertebrae (spina bifida) [3]. It can involve one or more vertebral arches, determining extensive spinal dysraphism. Certain factors favor their appearance. According to the literature, only one article published in 1972 by Levy et al, which reported an incidence of 0.01% of thoracic spina bifida [3]. We report the case of a 33-day-old female infant born at term in breech presentation, with a pregnancy that was not well followed. There was a notion of taking fenugreek during pregnancy. Hospitalized for meningitis, with a dysmorphic face, clinically presented a dorsolumbar spina bifida (Figure 1). She had received antibiotic therapy and regular dressings since her admission. A cerebral-medullary scan was performed and showed a progressive opening of the spinous processes from the cervical and dorsal spine, more marked at the height of the spinous process of the fourth dorsal vertebra to distality, with issue of meningeal structures and spinal cord. Conflicts of interest: The authors declare that they have no conflicts of interest.
The Bee Honey Market in the State of Pará, Brazilian Amazon: An Econometric Model
Authors: Silva Joyce Monteiro da , Santos Marcos Antônio Souza dos , Santos Wânia Mendonça dos , Saraiva Joyce Dos Santos , Lopes Maria Lúcia Bahia , Costa Nilson Luiz , Soares Bruno Cabral , Loureiro João Paulo Borges de , Martins Cyntia Meireles , Martins Geany Cleide Carvalho
Published: April 2022

This study evaluates the effects of socioeconomic, environmental, and institutional variables on the bee honey market in the state of Pará, from 1990 to 2019. The generalized method of moments was used to create the econometric model for estimation. The results show that the supply of honey is price-inelastic and that the rate of forest deforestation strongly impacts honey production. The creation of the Federação das Associações de Apicultores do Estado do Pará was denoted an important institutional landmark for the beekeeping production chain; however, the effects of incentive policies such as rural credit are limited and do not meet the needs of beekeepers. Institutional market policies are ineffective and rarely accessed by beekeepers; however, they represent an opportunity to diversify marketing channels. Honey is a product of biodiversity that is economically classified as a superior good and its demand is price-inelastic. Honey and its derivatives lack marketing strategies to enable their competitive insertion in new markets and government programs; these would enable access to broader markets in cities and lead to the acquisition of more consumers in the future.
Hungarian birch mouse, Sicista trizona (Frivaldszky, 1865): past achievements, present status and future visions (Rodentia: Sminthidae)
Authors: Cserkész Tamás
Published: April 2022

The aim of this review is to provide a brief summary, based on a decade and a half of intensive research, of the past and future of the rodent species currently known as the Hungarian birch mouse, Sicista trizona (Frivaldszky, 1865). The species is endemic to the Carpathian Basin and listed as Endangered by International Union for Conservation of Nature. Past evidence is reinterpreted to provide an updated perspective on the species’ probable historical distribution and to discuss expectations for the future. In addition, a brief summary of previously unpublished results is provided: vegetation surveys of the known habitats, annual census and monitoring, genetic studies, and the launch of a captive breeding programme. Ten years ago, experts working on the conservation of this species were very pessimistic about its future, but today the results of the latest surveys, having knowledge of the appropriate management techniques and new directions in the species conservation, are encouraging. If we are able to maintain the Sicista research and conservation programme based on the results, and environmental factors do not change drastically, there is a good chance that we can manage to ensure long-term protection and maintenance for the population of Hungarian birch mouse. With five figures.
Authentic Assessment - The Right Choice for Students Studying Law?
Authors: Collins Toni
Published: April 2022

Law students benefit from authentic assessment. This was the clear result from a small study of the experiences of 16 law students in a new course where an assessment required them to write a research submission to a real entity. Students gained experience in undertaking a real-life task and the results were overwhelmingly positive and strongly in favour of authentic assessment. This article details the study undertaken. Although the findings must be read in the context of the study’s limitations, they do show the potential for authentic assessment to enhance students’ learning experiences by injecting meaning and purpose into their assessment tasks and better preparing them for legal practice.
The benefits and barriers of hosting students within allied health private practice settings: The perspective of private practice and clinical education coordinators
Authors: Forbes Roma , Dinsdale Alana , Copley Jodie , Booth Jodie , Cain Daniella , Crabb Meagan , Dunwoodie Ruth , Hunter Lucy , Sher Auriel , Hill Anne
Published: April 2022

Background: Allied health graduates are increasingly employed in private practice settings despite limited placement opportunities during training. Understanding the benefits and barriers of hosting allied health student placements is an important step in supporting initiatives to expand clinical placement capacity within this sector.

Aims: This study aimed to explore the benefits and barriers of hosting allied health students within private practice organisations from the perspective of practices who currently, have previously, and who have never hosted students and university clinical education coordinators.

Methods: A thematic analytical approach was applied to interview data (private practices n=26) and focus group data (clinical education coordinators n=13) and a thematic network tool was used to determine common themes.

Results: Three overarching themes were generated: 1) Local and wider perceived value of placements, 2) Challenges and concerns, and 3) Weighing up.

Conclusion: The findings of this study have highlighted a range of benefits and challenges of hosting students that are carefully weighed up by practices within allied health professions. The perceived benefits to the practice and staff, as well as the wider professions are weighed up against the required resources of time, physical spaces and opportunities for students to participate in client care.
Evaluation of Diabetic Patients’ Knowledge to Cutoff Osteoporosis at Diabetes Center in Duhok City
Authors: Khaleel Emad Elias , Atiyah Hussein Hadi
Published: April 2022

Background: Patients with T1DM had two to six fold greater of fractures hazard compared to healthy individuals, with the dangerous being highest in T1DM females. In a recent study examining the factors that influence bone break hazards in T1DM adult persons, about 50% of the participants said they had at least one fracture after being diagnosed with diabetes. With comparison of non-diabetic persons, those with T2DM get a 1.2- to 3-fold high prevalence of breakage, especially hip fractures and moreover forearm and leg fracture. Break incidence appear higher in people with a BMI of less than 30 kg/m2 comparing to obese people, and does not appear to differentiate much by gender. Longer duration of diabetes, poor levels of physical activity, sugar and systemically corticosteroid usage, and advancing ages are all linked to an increased fracture risk in T2DM patients. Falls are another cause of fractures, particularly in diabetic women. Aims: The present study conducted to evaluate the patients’ knowledge to put off osteoporosis among a sample from a diabetes center in Duhok city. Methodology: A descriptive design aimed to evaluate diabetic patients’ knowledge from 25 November 2020 to 26 June 2021. In order to get reliable data and a representative sample, a nonprobability (accidental) sample of 27 patients were selected from the diabetes center of Azadi teaching hospital in Duhok city. The statistical data analysis approaches used in order to analyze and assess the results of the study under the application of the statistical package (SPSS) ver. (22.0). Descriptive statistical data analysis and inferential data analysis were used to analyze the finding of the present study Results: The finding of the present study shows female were more than male, constituted 19 (70.4%). The distribution of the gender variable is coincident in the study, as it is high of females, age was between (50- 60) and constituted 12 (44.4%). With regard to the marital status, most of the participants were married and constituted 23(85.2%). Regarding the educational level, most of the participants do not read and write (illiterate) and constituted 12 (44.4%). Most of the participants had low knowledge score of Relative sufficiency coefficient (RS%) less than (33.34) about osteoporosis. Conclusion: Most of the participants were suffer from type two diabetes mellitus and most of them who visit a diabetes center had minimum knowledge toward osteoporosis. Instructional programs with a large sample should be designed for all diabetic patients with both types of diabetes to improve their knowledge about osteoporosis.
Assessment of the Frequency of Different Patterns of Clinical Presentation of Children Presenting with Congenital Adrenal Hyperplasia
Authors: v Muhammad , Raza Feezan , Hayat Moqeet , Bangulzai Attaullah , Gillani Syed Aqeel Akbar Shah , Jaffar Murtaza
Published: April 2022

Background: Congenital suprarenal hyperplasia is an autosomal recessive condition that is characterized by defects in some of the 5-enzymes required for cortisol synthesis. Literature indicates a high incidence of salt depletion and genital virilization in children with congenitally adrenal hyperplasia. The purpose of this study was to examine the prevalence of clinical patterns in children with congenital adrenal hyperplasia. Material and methods Study design: Cross sectional study Setting: Department of Pediatric, Fatima Memorial Hospital, Lahore. Duration: 6 months i.e. 19-12-2019 to 18-06-2020 Data collection: 92 infants who met the inclusion criteria were included in the study. Blood sample was obtained, if serum sodium was <135mEq/L, salt depletion was labeled. Then, genital examination for assessment of genital virilization was done. All data was entered in specially designed Performa and analyzed in SPSS. Results: The mean age of patients was 6.52±3.56 months. There were 49 (53.26%) male while 43 (46.74%) female infants. The mean weight of patients was 5.59±1.44 kg. There were 21 (22.83%) cases of consanguineous marriage while 71 (77.17%) were others. 63 (68.48%) had salt depletion while 29 (31.52%) did not had salt depletion. 39 (42.39%) patients had genital virilization while 53 (57.61%) did not have genital virilization. Conclusion: The frequency of patterns (salt depletion and genital virilization) of Congenital adrenal hyperplasia are high in local population. Keywords: Patterns, salt depletion, genital virilization, congenital adrenal hyperplasia, infants, consanguineous marriage
Circadian Maladministration 'S Position Sleeplessness, Insomnia and Role in Shifts Increased Risk of Heart Disease
Authors: Ramzan Talat , Ishaq Babar , Din Faheem Ud , Bangulzai Attaullah , Shah Gillani Syed Aqeel Akbar , Khajjak Noor
Published: April 2022

Around 124.6 million individuals experience the ill effects of cardiovascular ailments universally. The danger of cardiovascular ailments increments with propelling age in the two sexes. Circadian musicality is liable for a smoothed out working of different body capacities. Certain capacities and hormones have their pinnacle levels as per the organic day or evening of circadian cadence. Move work and rest issues like obstructive rest apnea can cause circadian misalignment that influences diverse metabolic, immunological, and cardiovascular capacities, which eventually expands the danger of cardiovascular illnesses. Our current research was conducted at Shaikh Zayed Hospital from Feb 2021 to Jan 2022. We methodically looked the online information base PubMed to discover papers on randomized controlled preliminaries from the past five years, assessing the function of move work and distinctive rest problems in causing circadian misalignment and its impact on the danger of cardiovascular maladies. Fifty papers were shortlisted, also, after the utilization of different incorporation and prohibition models, 18 papers were picked; and afterward after a careful investigation of the content, eight papers were chosen for the audit. All papers were assessed for quality. Two papers zeroed in on the impact of move take a shot at cardiovascular ailments, though five papers assessed the function of rest problems on circadian cadence and the danger of cardiovascular illnesses. Move work and rest related problems were found to cause circadian misalignment, and it was discovered to be related with an expansion in the danger of cardiovascular maladies. Dealing with these issues can help decrease the danger of cardiovascular infections. Keywords: Circadian Maladministration 'S Position Sleeplessness Heart Disease.
Incidence of Diabetic Retinopathy Amongst Persons who Screened Positive for Diabetes in five Neighborhood Eye Camps in Northern Multan Pakistan
Authors: Javed Ahmad , Mehfooz Asma , Choudhry Abdullah , Ahmed Nauman , Shamrez Kashaf , Bashir Hafiz Bilal
Published: April 2022

Aim: Lack of community data on diabetes-related blindness in Pakistan. In five neighborhood eye camps in northern Multan, Pakistan, we assessed the incidence of diabetic retinopathy amongst persons who screened positive for diabetes. Methods: In Multan, Pakistan's largest metropolis, five community-based eye camps were created in the May of 2021. Study participants had to be at least 32 years of age. They were tested for diabetes and go to an eye doctor for assessment of their diabetic retinopathy. We identified five eye clinics in Pakistan's largest metropolis, Multan, between May 2020 and April 2021 in Multan eye Hospital. All respondents were required to give verbal informed permission at the time of the assessment. It was determined that diabetic retinopathy was the most important outcome measure, which was classified into no proliferative, serious NPDR, and diabetic nephropathy retinopathy. It must have been predicated on a patient assessment. Results: There were 925 people tested for diabetes. 18% had diabetes: 2.9% had type I and 16.8% had type II. There were 138 individuals who went to the hospital for an ophthalmological checkup. Diabetic Retinopathy was found in 16.8% of the patients. There was a higher increase of diabetic retinopathy among persons with type I diabetes, those who had been diabetic for longer periods of time, and women. One of the most prevalent types of diabetes. Maculopathy (18.7 percent) and proliferative diabetic retinopathy were the two most prevalent forms of diabetic retinopathy, respectively (6.8 percent). Conclusion: We need more systematic study and population-based studies to establish the occurrence of diabetic retinopathy in Pakistan and the potential things that affect to it. Keywords: Diabetic Retinopathy, Screened Positive for Diabetes, Northern Multan Pakistan.
Prevalence and Susceptibility Profile of E. Coli O157:H7 Isolated from Raw Milk in Kohat, Pakistan
Authors: Zada Hakeem , Maitlo Amjad Ali , Hassan Zaidi Syed Zahoor Ul , , Fatima Komal , Shah Mir Sadiq , Khan Malik Waleed Zeb , Shaheen Ghazala , Shamim Tahira , Sumreen Laila
Published: April 2022

Diseases development due to food is a major threat to consumers; especially in countries where sanitation facilities are poor. E. coli O157:H7 strain causes major outbreaks among foodborne diseases. The current work investigated the prevalence of E. coli O157:H7 and their antibiogram profile in raw milk samples. A total of 180 samples were collected from milk shops in Kohat, Pakistan. The isolates were initially identified on colony morphology on different Media and later through biochemical tests. Isolates were also screened to differentiate E. coli O157:H7 from other fecal E. coli via sorbitol MaCconkey agar. Out of 180 samples 134 (74.4%) milk samples were positive for E. coli and 46 (25.6%) milk samples were negative. Antibiotic susceptibility test was performed by using antibiotics of different classes. Most of the isolates showed susceptibility to ciprofloxacin (82.5%) (80.4%), gentamicin (82.5%) (80.5%) and Oxytetracycline (85.5%) (85.6%) respectively and slightly resistant to Tetracycline (55.8%) (48.2%), Imepenam (52.6%) (42.8%), Ceftriaxone (45.5%) (40.6%), Trimethoprim (54.4%) (36.6%), Chloramphenicol (38.6%) (30.5%), and shows resistance to Amikacin (25.5%) (18.4%) and Cloxacillin (10.5%) (4.5%) respectively. The high frequency of E. coli O157:H7 in milk samples indicate poor hygiene during milking, transportation and milk storage. The awareness against spreading of this pathogen is necessary among stakeholders at different levels of milk handling. Keywords: E. coli O157:H7; Antibiotic resistance, Milk
Turkish Validity and Reliability Study of the Functional Independence and Difficulty Scale in Older Adults
Authors: SERTEL Meral , TÜTÜN YÜMİN Eylem , ÖZEL Alp
Published: April 2022

Aim: The present research aims to investigate the suitability of the Functional Independence and Difficulty Scale (FIDS) to the Turkish version and society and the efficiency of its clinical use and bring it into use for other researchers.

Materials and Methods: One hundred forty older adults living in the society were enrolled in the research. The physical characteristics and clinical states of the individuals were recorded during their first evaluation, and their cognitive states were evaluated by the Mini-Mental State Examination (MMSE). The Turkish Version of the Functional Independence and Difficulty Scale (FIDS) was translated by professionals to investigate its validity and reliability. To test the validity, the Barthel Index for Activities of Daily Living (Barthel ADL) and the Katz Index of Activities of Daily Living (Katz Index ADL) were applied in the study. For the test-retest reliability, a retest was performed two weeks later by the same physiotherapist.

Results: The ICC value of the FIDS was found to be 0.999 (95% CI; 0.995–1.000 excellent agreement).According to the correlation analysis, a high correlation was detected between the first and second assessments of the FIDS (p
Obezite Tedavisinde Tartışmalı Bir Konu: Öğün Sıklığı
Authors: BAKAN Sevinç , GEZMEN KARADAĞ Makbule
Published: April 2022

Obezite, dünya çapında giderek yaygınlaşan tüm yaş gruplarını tehdit eden önlenebilir bir hastalıktır. Obezitenin önlenmesi ve tedavisinde etkili olabilecek birçok yöntem mevcuttur. Sağlıklı beslenme, fiziksel aktivitenin arttırılması ve davranış değişikliği terapilerinin bir arada uygulanması sağlıklı vücut ağırlığına ulaşmada en etkili yöntem olarak önerilmektedir. Öğün sıklığı, obezitenin tıbbi beslenme tedavisinde yer alan tartışmalı konulardan biridir. Öğün sıklığının arttırılmasının sağlıklı vücut ağırlığının korunması ve iştah kontrolünde faydalı olabileceğini bildiren araştırmalar olsa da öğün sayısını azaltarak daha büyük porsiyonlu öğünler tüketmenin tokluk ve enerji harcamasını arttırdığını rapor eden çalışmalar da yapılmıştır. Özellikle kahvaltıyı atlamanın obezite riski ile ilişkisine dair birçok çalışma mevcuttur. İlgili çalışmalarda konu hakkında kabul görmüş bir terminolojinin olmayışı, değişik grupların birbiri ile kıyaslanması ve araştırmaların farklı yöntemler ile yapılması obezite ile öğün sıklığı ilişkisi hakkında genel ve net çıkarımlar yapmayı engelleyen temel sebepler olarak bildirilmiştir. Öğün sıklığındaki değişimlerin obezitenin önlenmesi ve tedavisindeki olası rolünü incelemek için yapılan bu derleme çalışmasında da benzer engeller ile karşılaşılmıştır. Sonuç olarak öğün sıklığının obezite ile ilişkisini açıklayabilmek için farklı yaş gruplarında ortak metodoloji ve terminoloji oluşturularak, öğün sayısı ile birlikte diyet kalitesinin de sorgulandığı daha uzun vadeli çalışmalara ihtiyaç olduğu vurgulanmıştır.
Pakistan-Turkmenistan Relations: Evaluating the Progress on TAPI
Authors: Mir Sherbaz Khetran
Published: April 2022

Turkmenistan and Pakistan enjoy mutually respectful and cordial relations underpinned by history, culture and religion. Both countries value people-to-people ties and underscore the need to further augment bilateral cooperation in a variety of fields. China-Pakistan Economic Corridor (CPEC), a component of Belt and Road Initiative (BRI), provides an opportunity to enhance bilateral cooperation and shift the focus of relationship to addressing socio-economic challenges, building economic linkages and enhancing bilateral trade. Turkmenistan-Afghanistan-Pakistan-India (TAPI) gas pipeline is one of the most effective development projects since the countries of the region are energy starved. The collective address to the common handicap will also play a vital role in the regional economic upswing. Most importantly, new avenues of cooperation can promote a common understanding of evolving regional and international issues of interest to both countries.
MODELO EXPERIMENTAL DE PERFUSÃO CARDÍACA EX VIVO
Authors: Assis dos Reis Filho Valdir
Published: April 2022

Diversos sistemas de perfusão de órgãos isolados foram desenvolvidos e implantados na prática de transplante, tendo como principal finalidade a manutenção da estabilidade dos enxertos por tempos prolongados. A perfusão ex vivo oferece aparatos para preservar o tecido cardíaco, manter os impulsos elétricos e estabelecer um estado metabólico adequado. Novas técnicas de preservação precisam ser discutidas e apresentadas, no sentido de ampliar perspectivas futuras para melhorar a proteção miocárdica no contexto do transplante cardíaco.
Konceptualne i organizacione karakteristike daljeg obrazovanja
Authors: Alibabić Šefika
Published: April 2022

The purpose of this paper is to analyse conceptual and organisational features of further education - the status of further education concept in the notional conceptual system of further education studies, as well as the place of further education in educational system; to identify the bearer of organization and program orientation of further education in practice, enviromental factors which stimulate or inhibit the idea of further education; to point out the scientific and research activities in the field; and, based on this, to comprehend further education prospects in Serbia. For this purpose, available and relevant goverment and non-goverment sectors' data and empirical research results about the shape aspects form of further education have been used. Strategic analysis method has been used to identify strenghts and weaknesses, opportunities and threats for further education, which represents the for ground basis foundation framework mild optimism for further education planing in our educational system.
Large-Scale Land Acquisition and Economic Development
Authors: Purbawa Yudha
Published: April 2022

ABSTRACTThe development of Yogyakarta International Airport (YIA) has been accomplished, and even now the airport is currentlyoperating, serving the flight from and to Yogyakarta Special Province. However, the pro and cons of the YIA developmentremain. Some argue the YIA brought economic development for locals, while others argue the YIA made the locals worse-off.This paper describes the author’s view on this opposite perspective by reviewing several scientific articles regarding the YIA.The author supports the idea that the new airport of Yogyakarta has the potential to boost local economic development dueto some conditions, they are sufficient compensation, productive use of compensation, the high number of flight destinations,and government intervention to involve the local sources. In addition, further research to estimate the average effect of YIAland acquisition compensation and the YIA existence on local economic development by using causal inference techniques isrequired to ensure the most objective study result.Keywords : large-scale land acquisition, economic development, Yogyakarta International Airport.
ABSTRAKPembangunan Bandara Internasional Yogyakarta (YIA) telah selesai dan saat ini telah beroperasi melayani penerbangan daridan menuju Provinsi Daerah Istimewa Yogyakarta (DIY), namun masih ada pendapat pro dan kontra mengenai pembangunanYIA. Beberapa pihak berpandangan bahwa YIA membawa pembangunan ekonomi bagi penduduk setempat, sedangkanbeberapa pihak lain berpendapat bahwa YIA malah memperburuk kondisi perekonomian warga lokal. Artikel ini menyajikanpandangan penulis terhadap perbedaan perspektif tentang YIA ini dengan mengulas beberapa tulisan ilmiah tentangpembangunan YIA. Penulis berpendapat bahwa pembangunan YIA memiliki potensi untuk dapat menciptakan kemajuanekonomi lokal karena memenuhi beberapa persyaratan, yaitu ganti rugi yang cukup, penggunaan uang ganti rugi untuk halproduktif, tingginya angka penerbangan tujuan ke DIY, dan intervensi pemerintah dalam memanfaatkan sumber daya lokal.Untuk mencapai hasil studi paling objektif, maka dibutuhkan penelitian lebih lanjut untuk menghitung secara rata-rata dampakdari ganti rugi lahan bandara YIA dan dampak dari keberadaan bandara YIA terhadap parameter pembangunan ekonomidengan menggunakan metode-metode pengukuran sebab-akibat.Kata kunci : pengadaan tanah skala besar, pembangunan ekonomi, Bandara Internasional Yogyakarta.
PENGARUH TEKNIK MESSAGE TERHADAP PENGURANGAN NYERI PERSALINAN KALA 1 FASE AKTIF DI PUSKESMAS BILOKKA KABUPATEN SIDRAP TAHUN 2021
Authors: Kalsum Umi , H Hasrida , J Jusmawati , Ghita Dwi
Published: April 2022

Tujuan penelitian ini adalah untuk mengetahui gambaran pengaruh teknik massege terhadap pengurangan nyeri persalinan kala 1 fase aktif di Puskesmas Bilokka Kabupaten Sidrap. Nyeri saat persalinan meningkatkan kesemasan pada ibu yang meningkatkab resiko terjadinya persalinan lama dan itngginya angka section cesarea. Karena ini sebagai titik penentu apakah seorang ibu bersalin dapat menjalani perslinan normal atau diakhiri dengan suatu tindakan dikarenakan adanya penulit yang diakibatka  nyeri yang sangat berat, maka sangat penting untuk menolong persalinan memenuhi kebutuhan ibu akan rasa aman dan nyaman. Salah satu upaya untuk mengurangi rasa nyeri persalinan adalah dengan teknik massege.

Penelitian ini menggunakan metode peneltian preeksperien dengan rancangan penelitian one group pretest posttest. Sampel diambil menggunakan teknik purposive sampling, yaitu sebanyak 20 ibu bersalin. Instrument yang digunakan dalam penelitian ini adalah lembar observasi. Data tersebut dianalisis dengan dua macam teknik analisis bivariat dengan menggunakan program spss 24. Sebelum melaksanakan teknik massege sebagian besar responden berada pada skala 406 (nyeri sedang) sebanyak 11 orang (55%). Sesudah dilakukan teknik massege sebagian besar responden berada pada skala 4-6 (nyeri ringan) sebanyak 14 orang (70%). Hasil uji t diperoleh nilai signifika (0,000 < 0,05) artinya Ho ditolak dan Ha diterima. Sehingga dapat disimpulkan terdapat pengaruh teknik massege terhadap pengurangan nyeri persalinan kala 1 fase aktif di puskesmas bilokka kabupaten sidrap.
Docking, synthesis and biological evaluation of pyridine ring containing Diaryl urea derivatives as anticancer agents
Authors: Marvaniya Vanita , Joshi Hirak V. , Shah Ujashkumar A. , Patel Jayvadan K. , Patel Jimish R.
Published: April 2022

A novel series of pyridine ring containing diaryl urea derivatives (R1-R9) were synthesized in four chemical steps using pyridine-2-carboxylic acid as starting material. The synthesized compounds were design by using Autodock vina in the crystal structure of the Kinase domain of Human B-raf (PDB ID: 4DBN) to get insights into structural requirements for anticancer activity. In vitro anticancer activity against cell line (MCF-7) showed that compounds R3, R6 and R9 were found to be the most potent (Docking score: > -12, IC50 = 17.39 µM) among the synthesized molecules.
Assessing the effect of chemical surface treatment and joint surface preparations on transverse strength of repaired denture base resin
Authors: Sonune Shital J. , Karthik Sahana , Lunkad Honey , Chopra Arushi , Gupta Hitesh
Published: April 2022

The present study was conducted to assess the effect of chemical surface treatment and joint surface preparations on transverse strength of repaired denture base resin. The study included 120 specimens divided into 8 groups of 15 samples each based on the combination of chemical surface treatment with either methyl methacrylate, ethyl acetate, or methylene chloride and chemical surface treatment of rounded joint, 45° bevel, and butt joint. Following surface treatment, dentures were repaired with self-cure resin. After treatment, to assess the transverse strength, they were subjected to a 3‑point bending test. Surfaces that were fractured were assessed under the microscope and were analyzed to AutoCAD for assessing cohesive or adhesive failure type and the area was measured. The study results showed that a statistically significant difference was seen in most of the comparisons done. Specimens with rounded joints and methylene chloride used for 60 seconds showed the gain of strength of 60%-70& in the present study. The present study concludes that to attain better bond strength in a specimen repaired, the fractured segments of the specimens should be etched with methylene chloride for 60 s and should be given the rounded joints.
Evaluation of an educational film as a learning tool for nurses caring for seniors with pressure ulcers
Authors: Ibrahim Fatma Magdi
Published: April 2022

Background:  Pressure ulcers last to be a severe and prevalent health condition in hospitals; they have been considered the most physically debilitating and expensive problems of the twentieth century. Advanced pressure ulcers are common in the elderly; about 70% happen in cases 65 years or older, peaking range from 70 and 80. Many pressure ulcers are considered preventable or even treatable with the proper procedures to preserve skin integrity. Objectives: This work aims to evaluate the influence of an instructional film on nurses caring for seniors with pressure ulcers in terms of attitude and knowledge. Materials and Method. The research employed a quasi-experimental design and was conducted in intensive care Units of the General Mansoura Hospital, Specialized Medical Hospital, and Emergency Hospital in Dakhalia governorate. The research surveyed 69 nurses. Two instruments were utilized in this research: the Braden Scale and a two-part structured interview schedule sheet. Results: Following the educational film, the nurse's practice and knowledge increased, plus there was an enhancement in wound healing of pressure ulcers for older adults. Conclusion: This study concluded that nurses' knowledge and attitude have improved after displaying the educational film program.
The Danger of Small Lies: Dishonesty can snowball
Authors:   Character Lab, Sharot Tali
Published: April 2022

At 8 p.m. every night, my 6-year-old son happily heads upstairs to bed—just as long as his older sister does, too. He can’t bear the thought of her having fun while he is asleep. She, on the other hand, does not need as much sleep. What to do?