bluuebunny/crossref_metadata_2025 huggingface dataset:
Quasihomeomorphisms and Skula spaces
Authors: Echi Othman
Published: October 2021

Let [Formula: see text] be a topological space. By the Skula topology (or the [Formula: see text]-topology) on [Formula: see text], we mean the topology [Formula: see text] on [Formula: see text] with basis the collection of all [Formula: see text]-locally closed sets of [Formula: see text], the resulting space [Formula: see text] will be denoted by [Formula: see text]. We show that the following results hold:

(1) [Formula: see text] is an Alexandroff space if and only if the [Formula: see text]-reflection [Formula: see text] of [Formula: see text] is a [Formula: see text]-space. (2) [Formula: see text] is a Noetherian space if and only if [Formula: see text] is finite. (3) If we denote by [Formula: see text] the Alexandroff extension of [Formula: see text], then [Formula: see text] if and only if [Formula: see text] is a Noetherian quasisober space.

We also give an alternative proof of a result due to Simmons concerning the iterated Skula spaces, namely, [Formula: see text].

A space is said to be clopen if its open sets are also closed. In [R. E. Hoffmann, Irreducible filters and sober spaces, Manuscripta Math. 22 (1977) 365–380], Hoffmann introduced a refinement clopen topology [Formula: see text] of [Formula: see text]: The indiscrete components of [Formula: see text] are of the form [Formula: see text], where [Formula: see text] and [Formula: see text] is the intersection of all open sets of [Formula: see text] containing [Formula: see text] (equivalently, [Formula: see text]). We show that [Formula: see text]
A Literature Review of MADM Applications for Site Selection Problems — One Decade Review from 2011 to 2020
Authors: Zolfani Sarfaraz Hashemkhani , Hasheminasab Hamidreza , Torkayesh Ali Ebadi , Zavadskas Edmundas Kazimieras , Derakhti Arman
Published: October 2021

Site selection is a multi-dimensional optimization problem that influences a wide variety of stakeholders from local communities and authorities to governments, environmental protection agencies, etc. Locating an energy project as well as transportation infrastructure projects, for instance, are of great strategic importance and are connected to the top-level regulations and policy levels. These problems are significant from strategic levels to the productivity of a single construction project level, from energy to transportation and from infrastructure to residential buildings.

A large number of publications in this field of study prove this significance. However, regarding the variety of applications, managerial decision levels, and the growing number of studies, it is important to comprehend the latest trends and conclude an appropriate research path in this field.

This study is mainly focused on the application of MADM methodologies on locating problems by which many studies are carried out and have a high coincidence with the locating problem environment. Consequently, 425 studies are considered in this study, and 217 more relevant papers are selected for the subsequent reviews. Based on the results, Energy projects are by far the most frequent field of study in this regard which are considered as renewable and nonrenewable categories. Also, environmental planning and sustainable site selection are of secondary importance.
Generalized Reynolds operators on 3-Lie algebras and NS-3-Lie algebras
Authors: Hou Shuai , Sheng Yunhe
Published: October 2021

In this paper, first, we introduce the notion of a generalized Reynolds operator on a [Formula: see text]-Lie algebra [Formula: see text] with a representation on [Formula: see text]. We show that a generalized Reynolds operator induces a 3-Lie algebra structure on [Formula: see text], which represents on [Formula: see text]. By this fact, we define the cohomology of a generalized Reynolds operator and study infinitesimal deformations of a generalized Reynolds operator using the second cohomology group. Then we introduce the notion of an NS-[Formula: see text]-Lie algebra, which produces a 3-Lie algebra with a representation on itself. We show that a generalized Reynolds operator induces an NS-[Formula: see text]-Lie algebra naturally. Thus NS-[Formula: see text]-Lie algebras can be viewed as the underlying algebraic structures of generalized Reynolds operators on [Formula: see text]-Lie algebras. Finally, we show that a Nijenhuis operator on a 3-Lie algebra gives rise to a representation of the deformed 3-Lie algebra and a 2-cocycle. Consequently, the identity map will be a generalized Reynolds operator on the deformed 3-Lie algebra. We also introduce the notion of a Reynolds operator on a [Formula: see text]-Lie algebra, which can serve as a special case of generalized Reynolds operators on 3-Lie algebras.
Investigation on Thrust and Torque Generation During Drilling of Hybrid Laminates Composite with Different Stacking Sequences Using Multiobjective Optimization Module
Authors: Dubey Ankit Dhar , Kumar Jogendra , Kesarwani Shivi , Verma Rajesh Kumar
Published: October 2021

This paper highlights the reinforcement of two different fibers in the manufacturing of hybrid laminate composites. The feasibility of glass and carbon fiber-based hybrid composites is proposed for various high performances due to their versatile mechanical properties. However, anisotropic and non-homogeneity nature creates several machining challenges for manufacturers. It can be regulated through the selection of proper cutting conditions during the machining test. The effect of process constraints like spindle speed (rpm), feed rate (mm/min), and stacking sequences ([Formula: see text] was evaluated for the optimum value of thrust force and Torque during the drilling test. The cost-effective method of hand layup has been used to fabricate the composites. Four different hybrid composites were developed using different layers of carbon fiber and glass fiber layers. The outcomes of variables on machining performances were analyzed by variation of feed rate and speed to acquire the precise holes in the different configurations. The application potential of the proposed composites is evaluated through the machining (drilling) efficiency. The optimal condition for the drilling procedure was investigated using the multiobjective optimization-Grey relation analysis (MOO-GRA) approach. The findings of the confirmatory test show the feasibility of the MOO-GRA module in a machining environment for online and offline quality control.
Spread and control of COVID-19: A mathematical model
Authors: Misra O. P. , Sisodiya Omprakash Singh
Published: October 2021

A mathematical model is proposed in this paper to study the transmission and control of COVID-19. The mathematical model is formulated using system of nonlinear ordinary differential equations. The model includes disease-related parameters such as contact rate, disease-induced death rates, immigration rate and transition rates along with parameters for control measures such as implementation of social distancing practices, isolation and quarantine rates. From the stability analysis of the model, it is shown that if the social distancing is practiced by the large number of susceptible population, then the disease will not spread, and it may eventually die out. Further, it is derived from the analysis of the model that if most of the infected populations are isolated or quarantined, then the spread of the disease can be eventually controlled. However, from the analysis of the model, it is observed that if there is constant immigration of asymptomatic infected persons, then the disease will continue to spread and will remain pandemic. For controlling the disease, two more parameters, that is, vaccination and testing rates, are introduced in the original mathematical model and from the numerical analysis of this model, it has been shown that the control strategy involving vaccination and testing in combination can have synergistic effect for minimizing the COVID-19 infected cases.
Cell-Incorporated Bioactive Tissue Engineering Scaffolds made by Concurrent Cell Electrospinning and Emulsion Electrospinning
Authors: Sun Haoran , Zhao Qilong , Zheng Li-Wu , Lu William W. , Wang Min
Published: October 2021

Electrospun fibrous scaffolds attract great attention in tissue engineering owing to their high similarity in architecture to the extracellular matrix (ECM) that support cell attachment and growth in human bodies. Although they have shown superiority in promoting cell attachment and proliferation on their surfaces and hence, hold great promise for the regeneration of body tissues, the research still faces a great challenge of three-dimensional (3D) cell incorporation in electrospun scaffolds to form thick and cell-dense constructs because deep cell infiltration is hard to achieve in conventional electrospun scaffolds that normally have very small diameters of interconnected pores. Such hindrance has severely limited the clinical application of electrospun fibrous scaffolds to repair/regenerate various body tissues, particularly those with complex anatomies. To address this challenge, we have developed a concurrent cell electrospinning and emulsion electrospinning technique for fabricating bioactive bio-hybrid scaffolds with 3D and high-density cell incorporation. Through concurrent electrospinning, cell-encapsulated hydrogel fibers (“cell fibers”) and growth factor-containing ultrafine fibers are simultaneously deposited to form two-component scaffolds (i.e., scaffolds composed of two types of fibers) according to the design. With the breakup of cell fibers, live cells with well-preserved cell viability are released in situ inside the scaffolds, resulting in the creation of cell-incorporated bioactive scaffolds with ECM-mimicking fibrous architectures and 3D and high-density incorporation of cells. The growth and functions of incorporated cells in the scaffolds can be enhanced by the released growth factor from the emulsion electrospun fibrous component. The bioactive bio-hybrid scaffolds fabricated via concurrent electrospinning mimic the cell-matrix organization of body tissues and therefore have great potential for regenerating body tissues such as tendon and ligament.
Experimental investigation of modified co-curing process for carbon fiber/epoxy-laminates
Authors: Motsch-Eichmann Nicole , Rieger Florian , Rief Thomas , Hausmann Joachim
Published: October 2021

In this study, thermoset-based carbon fiber-reinforced polymer structures manufactured by the so-called modified co-curing process are analyzed and compared to well-established co-curing and co-bonding. The modified co-curing process allows manufacturing geometrically complex parts without traditional core technologies by producing laminates from a un-cured half and a pre-cured half in contrast to using two un-cured halves (co-curing) or a fully cured half plus an un-cured half (co-bonding). The interlaminar fracture toughness under Mode I loading, [Formula: see text], was determined in double cantilever beam (DCB) tests. [Formula: see text] displays a correlation of the degree of cure and the joint properties, with the co-curing laminates having 11% and 33% higher fracture toughness than the modified co-curing configurations. However, modified co-curing in all cases results is superior or equal to co-bonding. To assess the influence of surface properties for the bonding quality, different peel plies were compared with respect to the resulting joint properties. The results with up to 50% loss in [Formula: see text] values indicate the high importance of appropriate surface preparation. Subsequent tests also show that the negative influence of the peel ply on the joint properties can be reversed by abrasive surface treatment. It was found that at higher degrees of partial curing before co-curing, crack growth increasingly occurs in the interface of the bonded laminates. Therefore, the properties of the surface before joining were analyzed and modified to assess its relevance for the bonding properties and the potential for improvement.
Understanding reasons for electing gap years between undergraduate education and medical school and the impact of gap years on the student experience of medical education
Authors: Rashid Haroon , Kibble Jonathan D.
Published: October 2021

Gap years have grown in popularity among students attempting to go to medical school in recent years. According to the Association of American Medical Colleges (AAMC), more than half of matriculated students now have taken time off between their undergraduate studies and medical school. Although many claim benefits to taking gap years, research on the impacts of these experiences on medical students is largely nonexistent. This study aimed to qualitatively analyze the gap year phenomenon and its impacts on medical students through semistructured interviews conducted at the University of Central Florida College of Medicine. Through these interviews, the research team collected in-depth responses that were thematically analyzed. Analysis revealed the following major themes regarding the impacts of gap years: 1) adaptability to change and failure, 2) professional identity formation and understanding of team role, 3) understanding the “real world,” 4) refocusing of goals, 5) resilience and stress management, and 6) reinforcement of motivation.
Integrating active learning activities and metacognition into STEM writing courses
Authors: Zhang Hongmei , Li Yanju
Published: October 2021

Although active learning is highly recognized and recommended in the educational community, instructors are still struggling with how to incorporate active learning tools into writing courses. This study aims to 1) describe specific challenges encountered in the course of Molecular Cell Biology Laboratory–Critical Thinking through Writing (BIOL3810-CTW); 2) introduce the active learning approaches and metacognition integrated into this writing-intensive course; 3) demonstrate the effectiveness of these active learning approaches in engaging students in classes; and 4) share the principles of integrating active learning activities into writing courses in science, technology, engineering, and mathematics (STEM) and beyond.
Guidelines for in vivo mouse models of myocardial infarction
Authors: Lindsey Merry L. , Brunt Keith R. , Kirk Jonathan A. , Kleinbongard Petra , Calvert John W. , de Castro Brás Lisandra E. , DeLeon-Pennell Kristine Y. , Del Re Dominic P. , Frangogiannis Nikolaos G. , Frantz Stefan , Gumina Richard J. , Halade Ganesh V. , Jones Steven P. , Ritchie Rebecca H. , Spinale Francis G. , Thorp Edward B. , Ripplinger Crystal M. , Kassiri Zamaneh
Published: October 2021

Despite significant improvements in reperfusion strategies, acute coronary syndromes all too often culminate in a myocardial infarction (MI). The consequent MI can, in turn, lead to remodeling of the left ventricle (LV), the development of LV dysfunction, and ultimately progression to heart failure (HF). Accordingly, an improved understanding of the underlying mechanisms of MI remodeling and progression to HF is necessary. One common approach to examine MI pathology is with murine models that recapitulate components of the clinical context of acute coronary syndrome and subsequent MI. We evaluated the different approaches used to produce MI in mouse models and identified opportunities to consolidate methods, recognizing that reperfused and nonreperfused MI yield different responses. The overall goal in compiling this consensus statement is to unify best practices regarding mouse MI models to improve interpretation and allow comparative examination across studies and laboratories. These guidelines will help to establish rigor and reproducibility and provide increased potential for clinical translation.

Listen to another corresponding podcast at https://ajpheart.podbean.com/e/guidelines-for-in-vivo-mouse-models-of-myocardial-infarction/ .
Optimization Algorithm and Simulation of Public Resource Emergency Scheduling Based on Wireless Sensor Technology
Authors: Zhou Yi , Xia Weili
Published: October 2021

Public resource scheduling refers to the rational allocation and effective use of resources, while public emergency scheduling refers to the rational allocation and effective use of resources in the context of emergencies. Its main purpose is to reduce casualties and property losses caused by emergencies. This paper mainly studies the emergency scheduling of public resources based on line sensing technology and solves the scheduling problem of public resources through algorithm optimization. Firstly, combined with the positioning algorithm of wireless sensor, this paper optimizes the positioning and detection technology of wireless sensor technology. Then, we design an improved multiagent genetic algorithm (MAGA‐MTERS) using natural number coding and design a penalty function to solve the model. Then, the algorithm is compared with the traditional genetic algorithm. The results show that the accurate positioning of wireless sensor technology can improve the efficiency of public resource scheduling and save the scheduling cost. The multiagent genetic algorithm optimizes the positioning function of wireless sensor. Compared with the traditional genetic algorithm, MAGA‐MTERS algorithm can obtain a better solution.
Impairment of Proprioception in Young Adult Nonradicular Patients with Lumbar Derangement Syndrome
Authors: Olszewska-Karaban Marzena , Permoda-Białozorczyk Anna , Dąbrowska Aneta , Bandurska Ewa , Permoda Andrzej , Zajt Jolanta , Sobierajska-Rek Agnieszka , Szalewska Dominika
Published: October 2021

Maintaining body balance is a complex function based on the information deriving from the vestibular, visual, and proprioceptive systems. The aim of the study was to evaluate quiet single stance stability in young adults with lumbar derangement syndrome (LDS) and in the control group of the healthy subjects. The second aim of this study was to determine whether pain intensity, degree of disability, and the level of physical activity can influence postural control in patients with LDS. It is important to underline that selecting a homogeneous group of LBP patients using, for example, mechanical diagnosis and therapy method and Quebec Task Force Classification, can result in an increased sensitivity of the study. The study included 126 subjects: 70 patients with LDS (37 women, 33 men) and the control group 56 healthy volunteers (36 women, 20 men). In case of multiple group comparisons for variables with normal distribution, ANOVA post hoc test was used or, as the nonparametric equivalent, Kruskal‐Wallis test. In all these calculations, the statistical significance level was set to p < 0.05. The stability index eyes open for the study group was 88.34 and for the control group 89.86. There was no significant difference in the level of postural control between the study and control groups (p > 0.05). The level of stability index eyes closed (SI EC) for the study group was 71.44 and for the control group 77.1. SI EC results showed significant differences in proprioceptive control during single leg stance between the study and control groups (p < 0.05). The level of pain intensity, the degree of disability, and physical activity level did not influence postural control in the study group with LDS. In summary, patients with LDS showed significantly worse proprioceptive control.
Analysis of Driving Factors of Innovation and Entrepreneurship Based on Time Series Analysis
Authors: Feng Jing
Published: October 2021

In order to analyze the driving factors of innovation and entrepreneurship, based on the time series analysis algorithm, this paper combines the analysis requirements of innovation and entrepreneurship driving factors to improve the time series, uses decomposition methods to decompose the complex original data into relatively simple components and reconstruct them, and predicts the reconstructed components to integrate the final predicted value. Moreover, this paper introduces entrepreneurial attitude as an intermediary variable and verifies it through data collection and statistical analysis, so that entrepreneurial traits influence entrepreneurial propensity through entrepreneurial attitude. The test results show that entrepreneurial attitude can better explain the influence of entrepreneurial traits on entrepreneurial propensity. In addition, this paper constructs an analysis model of driving factors for innovation and entrepreneurship, obtains experimental data through questionnaire survey methods, and conducts experimental research in combination with mathematical statistics. From the statistical results, it can be seen that the innovative and entrepreneurial driving factor analysis model based on time series analysis proposed in this paper is effective.
Evaluation of the Effect of FOXO3 rs13217795 Genotype and Minor Allele (C) on Clinical Chemistry and Genetic Risk of Diabetes Among the Elderly Individuals from Northern India
Authors: Hussain Sartaj , Yadav Suraj Singh , Banerjee Monisha , Usman Kauser , Khattri Sanjay
Published: October 2021

The forkhead box O family (FOXO) is expressed ubiquitously in a spatio-temporal manner and plays a key role in cellular metabolism, senescence, and aging. Genetic mutations in FOXO lead to metabolic diseases and cancer,and affect the longevity of individuals. Our study investigated how the genetic risk of type 2 diabetes mellitus (T2DM) altered due to an intronic variant rs13217795 of the longevity-associated FOXO3 gene in the geriatric population of North India. Genotypic characteristics of rs13217795 were determined among 347 age sex-matched (177 diabetic cases, 170 healthy controls) elderly individuals by TaqMan SNP assays after clinical assessment. Clinical chemistry and circulating cytokines level were assessed by biochemical and immunoassays. Genotype frequencies were not significantly (p = 0.526) different between cases and controls. The minor allele (C) frequency in diabetic cases and controls was 0.47 and 0.49, respectively (OR = 0.94, 95% CI = 0.69–1.26, p > 0.05). The minor allele was associated with lower fasting plasma glucose (FPG), fasting insulin, HOMA-IR, CRP, TNF-α, and IL-6 (p < 0.05). The homozygous minor allele carriers showed significantly lower levels of FPG, HOMA-IR, and TNF-α in T2DM patients. The minor allele (C) of intronic polymorphism in FOXO3 (rs13217795: T/C) confers the protective role characterized by its association with a decrease in glycemic and insulin resistance and proinflammatory markers.
Early Antibiotic Exposure Is Not Detrimental to Therapeutic Effect from Immunotherapy in Hepatocellular Carcinoma
Authors: Fessas Petros , Naeem Muntaha , Pinter Matthias , Marron Thomas U. , Szafron David , Balcar Lorenz , Saeed Anwaar , Jun Tomi , Dharmapuri Sirish , Gampa Anuhya , Wang Yinghong , Khan Uqba , Muzaffar Mahvish , Navaid Musharraf , Lee Pei-Chang , Bulumulle Anushi , Yu Bo , Paul Sonal , Nimkar Neil , Bettinger Dominik , Hildebrand Hannah , Abugabal Yehia I. , Pressiani Tiziana , Personeni Nicola , Nishida Naoshi , Kudo Masatoshi , Kaseb Ahmed , Huang Yi-Hsiang , Ang Celina , Pillai Anjana , Rimassa Lorenza , Naqash Abdul Rafeh , Sharon Elad , Cortellini Alessio , Pinato David J.
Published: October 2021

Background and Rationale: Immune checkpoint inhibitor (ICI) therapy is an expanding therapeutic option for hepatocellular carcinoma (HCC). Antibiotics (ATB) taken prior to or early during ICI therapy can impact immunotherapy efficacy across indications; however, the effect of ATB is undefined in HCC. Methods: In a large international cohort of 450 ICI recipients from Europe, North America, and Asia, we categorized patients according to timing of ATB focusing on exposure within −30 to +30 days from ICI (early immunotherapy period [EIOP]). EIOP was evaluated in association with overall survival (OS), progression-free survival (PFS), and best radiologic response using RECIST 1.1 criteria. Results: Our study comprised mostly cirrhotic (329, 73.3%) males (355, 79.1%) with a Child-Turcotte Pugh class of A (332, 73.9%), receiving ICI after 1 therapy line (251, 55.9%) for HCC of Barcelona clinic liver cancer stage C (325, 72.4%). EIOP (n = 170, 37.9%) was independent of baseline clinicopathologic features of HCC and correlated with longer PFS (6.1 vs. 3.7 months, log-rank p = 0.0135). EIOP+ patients had similar OS, overall response, and disease control rates (DCRs) compared to EIOP. The effect of EIOP persisted in landmark time analyses and in multivariable models, confirming the independent predictive role of EIOP in influencing PFS following adjustment for covariates reflective of tumor burden, liver function, and ICI regimen administered. In patients receiving programmed cell death-1 receptor/ligand inhibitors monotherapy, EIOP was also associated with higher DCRs (61.4% vs. 50.9%, p = 0.0494). Conclusions: Unlike other oncological indications, ATB in the 30 days before or after ICI initiation is associated with improved benefit from immunotherapy, independent of disease and treatment-related features. Evaluation of the immune microbiologic determinants of response to ICI in HCC warrants further investigation.
Pathological Diversity of Gastric Cancer from the Viewpoint of Background Condition
Authors: Abe Hiroyuki , Ushiku Tetsuo
Published: October 2021

Background: The prevalence of Helicobacter pylori infection and chronic atrophic gastritis is decreasing in Japan, which has led to a decline in the incidence of gastric cancer. However, there are various subtypes of gastric cancer that arise from the background mucosa without H. pylori infection, and their histological characteristics are distinct from those of gastric cancer with chronic atrophic gastritis. Summary: In this review, after a brief overview of conventional gastric carcinoma with H. pylori infection, including its molecular classification, histological characteristics of gastric cancer after eradicating H. pylori are described. The clinicopathological characteristics of gastric cancer independent of H. pylori infection are then explained. Autoimmune gastritis (type A gastritis) increases the risk of gastric adenocarcinoma and neuroendocrine tumors. Gastric carcinoma without H. pylori infection has various histological subtypes, including fundic gland-type adenocarcinoma (oxyntic gland adenoma), foveolar-type adenocarcinoma/adenoma, signet ring cell carcinoma, and adenocarcinoma of the esophagogastric junction. In addition, some familial gastric cancer syndromes, including hereditary diffuse gastric cancer, familial adenomatous polyposis, and gastric adenocarcinoma and proximal polyposis of the stomach, are also discussed. Key Messages: Although the incidence of gastric cancer will decrease in the near future, the diversity of gastric cancer pathology will be enhanced because H. pylori-negative gastric cancer will have a significant impact on the clinical practice guidelines for gastric cancer. Gastroenterologists and pathologists should be aware of the morphological diversity of H. pylori-negative gastric cancer, and attention should be paid to the status of the background gastric mucosa while examining gastric cancer.
10 Years of Experience with the First Thawed Plasma Bank in Germany
Authors: Selleng Kathleen , Greinacher Andreas
Published: October 2021

Background: Plasma is stored at –30°C, which requires thawing before transfusion, causing a time delay between ordering and issuing of at least 30 min. In case of bleeding emergencies, guidelines strongly recommend a 2:1 transfusion ratio of RBCs and plasma. In addition, each minute delay in issuing of blood products in bleeding emergencies increases the mortality risk. To provide plasma in time in bleeding emergencies, a thawed plasma bank was introduced in 2011. Summary: The thawed plasma bank of University Medicine Greifswald has provided 18,924 thawed stored plasma units between 2011 and 2020. The workflow in the laboratory as well as in the emergency room, the operating room, and the intensive care unit have been optimized by thawed stored plasma. In case of emergencies, the stress factor for the transfusion medicine laboratory staff has been reduced substantially. The thawed plasma bank allows to transfuse patients with massive transfusion demand at a 2:1 ratio of RBCs and plasma according to guidelines. To reduce storage time, we issue all plasma requests from the thawed plasma bank except for pediatric patients. This results in a median storage time in the thawed plasma bank of 24 h. The “just in time” availability of plasma within the entire hospital based on the thawed plasma bank has reduced precautionary ordering of plasma, and hereby the unnecessary use of plasma. After introduction of the thawed plasma bank, plasma usage decreased substantially by 24% within the first year and by 60% compared to 2019/2020. However, as the overall approach to using blood products has changed over the last 10 years due to the patient blood management initiative, quantification of the effects of the thawed plasma bank in reduction of plasma transfusion is difficult. Key Messages: (1) A thawed plasma bank for the routine supply of blood products in a large hospital is feasible in Germany. (2) The thawed plasma bank allows to supply RBCs and plasma in a 2:1 ratio in bleeding emergencies. (3) The beneficial logistical effects of the thawed plasma bank are optimal if all plasma requests are supplied from the thawed plasma bank. This results in a median storage time of 24 h for thawed plasma.
A Clinical Score to Predict “Corrected Thrombolysis in Myocardial Infarction Frame Count” in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
Authors: Ozkalayci Flora , Türkyılmaz Erdem , Karagoz Ali , Karabay Can Yucel , Tanboga İbrahim Halil , Oduncu Vecih
Published: October 2021

Corrected thrombolysis in myocardial infarction frame count (cTFC) is an objective, simple, and reproducible method to assess coronary blood flow which is a surrogate for cardiovascular outcomes. It is important to learn which factors are associated with cTFC. The goal of this study was to determine predictive models for epicardial blood flow assessed by cTFC and develop a diagnostic predictive model that indicates the individualized assessment of epicardial blood flow prior to primary percutaneous coronary intervention. This is a retrospective study including 3205 patients with ST-segment elevation myocardial infarction who underwent pPCI. The primary outcome was cTFC. Multivariable linear regression analysis was performed. Subsequently, a nomogram was developed to predict cTFC according to the candidate predictors. Median age was 58; the number of male patients was 2381 (74.3%). Median value of cTFC was 22 and interquartile range (IQR): 16.5–28.0). Age, diabetes mellitus (DM), total ischemic time, systolic blood pressure (SBP), heart rate (HR), and history of statin use remained in both full and reduced models. Our model may potentially allow clinicians to identify patients at high risk for impaired epicardial perfusion.
Understanding the Role of the Otolaryngology Hospitalist: Tracheostomies and Tracheostomy Care
Authors: Issa Mohamad , El-Kouri Nadeem , Mater Sara , Lee Jonathan Y. , Snyderman Carl , Lee Yan
Published: October 2021

Introduction:

The concept of a hospitalist has been well established. This model has been associated with reduced length of stay contributing to reduction in healthcare costs. Minimal literature is available assessing the effects of an otolaryngology (ENT) hospitalist at a tertiary medical center. The aim of this study is to assess the role of an ENT hospitalist on (1) performing tracheostomies and (2) providing care as part of the tracheostomy care team (TCT).

Methods:

Retrospective chart review of all tracheostomies performed by the ENT service over 2 years (July 2015-June 2017), and prospective data collection of all tracheostomy care consults over 1 year (July 2016-June 2017). In year 1 (from July 2015 to June 2016), no ENT hospitalist was employed, and in year 2 (from July 2016 to June 2017), an ENT hospitalist was employed.

Results:

Compared to other Ear, Nose, and Throat (ENT) surgeons, the ENT hospitalist performed tracheostomies with shorter patient wait times, and performed a greater proportion of percutaneous tracheostomies at the bedside versus open tracheostomies in the operating room. The tracheostomy care team (TCT) received 91 consults over the course of 1 year with an average of 1.1 billable procedures generated per consult.

Conclusion:

In this study, an ENT hospitalist was decreased patient wait time to tracheostomy and increased bedside percutaneous tracheostomies, which has positive implications for resource utilization and healthcare cost. The average wait time to receive a tracheostomy was reduced when calculated across the entire department due to the availability of the ENT hospitalist to see and perform tracheostomies. The TCT generated many billable bedside procedures in addition to encouraged decannulation of patients. This study highlights the fact that the ENT hospitalist contributes to providing expedient tracheostomies and provides valuable consulting services as part of a TCT at a high-volume tertiary care facility.
Biden’s China Policy: Old Wine in New Bottles?
Authors: Nathan Andrew J.
Published: October 2021

The Biden Administration has accepted the Trump Administration’s definition of China as a ‘strategic competitor’, and has retained Trump’s tariffs, the ‘Quad’, and the upgrade in Taiwan’s protocol status. But Biden’s China policy is different from Trump’s in being truly strategic. The key elements of that strategy are focused on improving the United States’ competitiveness domestically and in international affairs; cooperation with allies and partners; an emphasis on human rights; partial decoupling of economic and technology relationships; and a search for some areas of cooperation with China. Success for the Biden strategy would consist neither of bottling up China in its current global power position nor in achieving a negotiated condominium in Asia. The Biden Administration would succeed if the United States can maintain its alliance system, keep a robust military presence in East Asia and prevent the forcible integration of Taiwan into China while avoiding major war. Several features of the China challenge make it reasonable to hope that such success is possible.
Classic Psychedelic Use and Mechanisms of Mental Health: Exploring the Mediating Roles of Spirituality and Emotion Processing on Symptoms of Anxiety, Depressed Mood, and Disordered Eating in a Community Sample
Authors: Lafrance Adele , Strahan Erin , Bird Brian M. , St. Pierre Michelle , Walsh Zach
Published: October 2021

A resurgence of research has begun to systematically examine the relationship between psychedelic use and mental health and well-being. Although preliminary findings examining the therapeutic value of these substances show promise, the mechanisms through which psychedelic use may predict reduced mental distress remain poorly understood. To this end, we surveyed a community sample of individuals ( n = 159) who endorsed lifetime psychedelic use to examine relationships among psychedelic use and self-reported spirituality, difficulties in emotion regulation, and symptoms of mental health issues. Results revealed a pathway through which classic psychedelic use predicted greater spirituality, which in turn predicted better emotion regulation, ultimately predicting lower levels of anxiety, depressed mood, and disordered eating. These results contribute to our understanding of potential mechanisms of change with respect to psychedelics and mental health. They also add to the growing body of literature pointing to the healing effects of the cultivation of spirituality and emotion regulation as separate and related constructs.
Promoting New Psychological Understandings by Use of an Indigenous American Psychological Paradigm
Authors: Blume Arthur W.
Published: October 2021

Indigenous Americans are not well represented by mainstream psychology and its reductionistic tenets. As psychology developed, it could not help but to be implicitly biased by the surrounding hierarchical colonial culture—a culture in which Indigenous people and many others were conquered, oppressed, dehumanized, devalued, neglected, and excluded. An Indigenous worldview views humans as co-equal partners of an interdependent holistic system. Striving for healthy relationships with others is foundational to psychological health and well-being from an Indigenous perspective. Discrete entities (including self), independence, autonomy, and hierarchy are considered artificial mainstream conceptualizations that have negatively impacted the well-being of humans and the natural world. Indigenous American psychology appreciates the sacred nature of the whole and its entities, approaching professional psychology with the humility and respect that interacting with sacred entities warrants. Essential tenets of an Indigenous American Psychological Paradigm (IAPP) are discussed therein as an alternative to existing mainstream beliefs. An IAPP offers the ability to address intergenerational psychological problems holistically across time in ways that mainstream psychology has been unable. Psychology is ultimately strengthened by an ability to conceptualize psychology through the new lenses of alternative paradigms such as this one.
Development of an Abbreviated Adult Reading History Questionnaire (ARHQ-Brief) Using a Machine Learning Approach
Authors: Feng Luxi , Hancock Roeland , Watson Christa , Bogley Rian , Miller Zachary A. , Gorno-Tempini Maria Luisa , Briggs-Gowan Margaret J. , Hoeft Fumiko
Published: October 2021

Several crucial reasons exist to determine whether an adult has had a reading disorder (RD) and to predict a child’s likelihood of developing RD. The Adult Reading History Questionnaire (ARHQ) is among the most commonly used self-reported questionnaires. High ARHQ scores indicate an increased likelihood that an adult had RD as a child and that their children may develop RD. This study focused on whether a subset of ARHQ items (ARHQ-Brief) could be equally effective in assessing adults’ reading history as the full ARHQ. We used a machine learning approach, lasso (known as L1 regularization), and identified 6 of 23 items that resulted in the ARHQ-Brief. Data from 97 adults and 47 children were included. With the ARHQ-Brief, we report a threshold of 0.323 as suitable to identify past likelihood of RD in adults with a sensitivity of 72.4% and a specificity of 81.5%. Comparison of predictive performances between ARHQ-Brief and the full ARHQ showed that ARHQ-Brief explained an additional 10%–35.2% of the variance in adult and child reading. Furthermore, we validated ARHQ-Brief’s superior ability to predict reading ability using an independent sample of 28 children. We close by discussing limitations and future directions.
A novel intelligent ultra-local model control-based type-II fuzzy for frequency regulation of multi-microgrids
Authors: Sohrabzadi Erfan , Gheisarnejad Meysam , Esfahani Zahra , Khooban Mohammad Hassan
Published: October 2021

Due to the random nature of renewable energy in the micro-grid (MG) configuration, the energy generators in such systems are not able to offer an uninterrupted power and a mismatch between the demand and generation will be occurred. To alleviate this unbalance, technically, conventional storage devices are one of the practical solutions to this issue. However, the implementation of storage system is not effective from the economic preceptive and, as an alternative, the battery of electric vehicle can be also embedded in the structure of the MGs. In this work, an ultra-local model (ULM) controller based on a single-interval type-II fuzzy logic (SIT2-FL) controller is applied for frequency regulation of multi-MG(s) with electric vehicles. In this scheme, the ULM controller plays a critical role in the reducing the dependency of the controller to the MG model. An extended observer error is embedded in the structure ULM controller to remove the uncertainties included in the system. The SIT2-FL is established as supplementary controller to remove the error of observer and further ameliorate the multi-MG performance. Comparative simulation analysis and robustness examination are made to ascertain the usefulness of the suggested ULM controller-based SIT-FL.
autoFC: An R Package for Automatic Item Pairing in Forced-Choice Test Construction
Authors: Li Mengtong , Sun Tianjun , Zhang Bo
Published: October 2021

Recently, there has been increasing interest in adopting the forced-choice (FC) test format in non-cognitive assessments, as it demonstrates faking resistance when well-designed. However, traditional or manual pairing approaches to FC test construction are time- and effort- intensive and often involve insufficient considerations. To address these issues, we developed the new open-source autoFC R package to facilitate automated and optimized item pairing strategies. The autoFC package is intended as a practical tool for FC test constructions. Users can easily obtain automatically optimized FC tests by simply inputting the item characteristics of interest. Customizations are also available for considerations on matching rules and the behaviors of the optimization process. The autoFC package should be of interest to researchers and practitioners constructing FC scales with potentially many metrics to match on and/or many items to pair, essentially exempting users from the burden of manual item pairing and reducing the computational costs and biases induced by simple ranking methods.
Does music help regulate depressive symptoms for fans of violently themed music?
Authors: Powell Merrick , Olsen Kirk N , Thompson William Forde
Published: October 2021

Fans of extreme metal and rap music with violent themes, hereafter termed “violently themed music,” predominantly experience positive emotional and psychosocial outcomes in response to this music. However, negative emotional responses to preferred music are reported to a greater extent by such fans than by fans of non-violently themed music. We investigated negative emotional responses to violently themed music among fans by assessing their experience of depressive symptoms, and whether violently themed music functions to regulate negative moods through two common mood regulation strategies: discharge and diversion. Fans of violent rap ( n = 49), violent extreme metal ( n = 46), and non-violent classical music ( n = 50) reported depressive symptoms and use of music to regulate moods. Participants listened to four one-minute excerpts of music in their preferred genres and rated negative emotional responses to each excerpt (sadness, tension, anger, fear). There were no significant differences between ratings of depression between groups, but depressive symptoms predicted negative emotional responses to music across all groups. Furthermore, depression ratings predicted the use of the mood regulation strategy of discharge in all groups. The discharge strategy did not reduce (or exacerbate) fans’ negative emotional responses, but may nevertheless confer other benefits. We discuss implications for the psychosocial well-being of fans of violently themed music.
Psychological distress among patients awaiting histopathologic results after prostate biopsy: An unaddressed concern
Authors: Sarchi Luca , Eissa Ahmed , Puliatti Stefano , Amato Marco , Assumma Simone , Calcagnile Tommaso , Ticonosco Marco , Iseppi Andrea , Toso Stefano , Sighinolfi Maria Chiara , Bianchi Giampaolo , Micali Salvatore , Rocco Bernardo
Published: October 2021

Background:

Prostate cancer is the most commonly diagnosed neoplasm in men. From the introduction of PSA testing, an increasing number of men undergoes prostate biopsy (PBX). While the physical side effects of PBx have been well investigated, its psychological impact has been under-evaluated.

Aim:

The aim of our study is to investigate the presence of psychological distress (anxiety and depression) in patients waiting for histopathological results after prostate biopsy (PBx).

Methods:

From February to April 2019, 51 consecutive patients undergoing prostate biopsies at our institution were included. Age, PSA, DRE, familiarity for prostate cancer, number of previous biopsies, type of anesthesia, number of cores were recorded. All patients filled the Hospital Anxiety and Depression Scale (HADS), a psychometric Likert-scale questionnaire, before receiving the histopathological results of their PBx.

Results:

The prevalence of psychological distress among patients awaiting histopathologic results is 41% (21/51 patients), with anxiety being the main component of their distress. On multivariate analysis, PSA, family history, and repeat biopsy were significantly associated with anxiety and depression.

Conclusion:

Patients undergoing PBx experience a burden of psychological distress waiting for histopathologic results, especially anxiety. Appropriate counseling should be offered to patients at high risk of developing psychological distress after PBx. Future goals would include technological improvements to shorten the time between biopsy and definitive results.
Ireland's White Paper to End Direct Provision and Establish a New International Support Service (2021) and the ‘sticky’ discourse of control
Authors: Coakley Liam
Published: October 2021

The Government of Ireland has published its plan to reorder the infrastructure it uses to accommodate and support migrants seeking International Protection (IP) in Ireland. This policy document - entitled The White Paper to End Direct Provision and Establish a New International Support Service - was published on 26th February, 2021. The White Paper proposes to replace Ireland's current but discredited system with a new IP accommodation and support process – to be entitled Ireland's International Protection Support Service. This new system is intended to “treat all applicants to the process with dignity and respect” (Government of Ireland, 2021: 7). Dissonances exist, however. The discursive framing of the IPSS and the spatialities inherent in the proposals suggest a potential rearticulation of state control rather that a diminution of same. I turn to the work of scholars inspired by Giorgio Agamben to help situate the spatialities of this shift, and suggest that the current ‘white paper’ should simply be seen as a mechanism deployed the Government of Ireland to ensure that its bio-political command and control processes can migrate from the spatially-defined set of control environments currently in effect to a diffuse construction of a spatially networked series of deterritorialised indistinctions.
Formability study of bake hardening steel and its correlation with microstructure
Authors: Das Atanu , Kumar Basant , Ahmed Sheikh N , Paul Surajit Kumar , Mandal Gopi K
Published: October 2021

In the present study, the bake hardening (BH 240) steel sheet’s formability behavior is studied experimentally based on the Nakajima test method. A forming limit diagram is successfully constructed using universal sheet metal forming machine by offline measuring the strains of deformed specimens. In-process strain measurement based on a digital image correlation technique is also performed for a few selected samples to compare the results with manual strain measurement techniques. All the deformed specimens are also characterized to correlate the sample geometries with hardness values and microstructure. It is observed that the hardness value gradually decreases with an increase in sample width for all the deformed specimens up to the width of 150 mm, except for full-width sample of 200 mm. Microstructural analysis reveals that the morphology of ferrite grains changes with the sample geometry in all the deformed specimens. Microstructural characterization at the top surface of the specimen demonstrates that the aspect ratio of grains is maximum for a 25 mm width sample due to uni-axial stretching. It is also noted that grain’s aspect ratio is close to one (minimum) for a 200 mm width sample due to almost equi-biaxial elongation in grains. It is also observed that the aspect ratio of grains obtained from specimen cross-section indicates that the ratio increases gradually from 25 to 200 mm width samples.