bluuebunny/crossref_metadata_2025 huggingface dataset:
Circulating Klotho Is Higher in Cerebrospinal Fluid than Serum and Elevated Among KLOTHO Heterozygotes in a Cohort with Risk for Alzheimer’s Disease
Authors: Gaitán Julian M. , Asthana Sanjay , Carlsson Cynthia M. , Engelman Corinne D. , Johnson Sterling C. , Sager Mark A. , Wang Dan , Dubal Dena B. , Okonkwo Ozioma C.
Published: October 2022

Background: Klotho is a longevity and neuroprotective hormone encoded by the KLOTHO gene, and heterozygosity for the KL-VS variant confers a protective effect against neurodegenerative disease. Objective: Test whether klotho concentrations in serum or cerebrospinal fluid (CSF) vary as a function of KLOTHO KL-VS genotype, determine whether circulating klotho concentrations from serum and CSF differ from one another, and evaluate whether klotho levels are associated with Alzheimer’s disease risk factors. Methods: Circulating klotho was measured in serum (n = 1,116) and CSF (n = 183) of cognitively intact participants (aged 62.4 ± 6.5 years; 69.5% female). KLOTHO KL-VS zygosity (non-carrier; heterozygote; homozygote) was also determined. Linear regression was used to test whether klotho hormone concentration varied as a function of KL-VS genotype, specimen source, and demographic and clinical characteristics. Results: Serum and CSF klotho were higher in KL-VS carriers than non-carriers. Klotho concentration was higher in CSF than in serum. Females had higher serum and CSF klotho, while younger age was associated with higher klotho in CSF. Conclusion: In a cohort enriched for risk for Alzheimer’s disease, heterozygotic and homozygotic carriers of the KL-VS allele, females, and younger individuals have higher circulating klotho. Fluid source, KL-VS genotype, age, and sex should be considered in analyses of circulating klotho on brain health.
Mixed Pathologies in a Subject with a Novel PSEN1 G206R Mutation
Authors: Libard Sylwia , Giedraitis Vilmantas , Kilander Lena , Ingelsson Martin , Alafuzoff Irina
Published: October 2022

Background: There are more than 300 presenilin-1 (PSEN1) mutations identified but a thorough postmortem neuropathological assessment of the mutation carriers is seldom performed. Objective: To assess neuropathological changes (NC) in a 73-year-old subject with the novel PSEN1 G206R mutation suffering from cognitive decline in over 20 years. To compare these findings with an age- and gender-matched subject with sporadic Alzheimer’s disease (sAD). Methods: The brains were assessed macro- and microscopically and the proteinopathies were staged according to current recommendations. Results: The AD neuropathological change (ADNC) was more extensive in the mutation carrier, although both individuals reached a high level of ADNC. The transactive DNA binding protein 43 pathology was at the end-stage in the index subject, a finding not previously described in familial AD. This pathology was moderate in the sAD subject. The PSEN1 G206R subject displayed full-blown alpha-synuclein pathology, while this proteinopathy was absent in the sAD case. Additionally, the mutation carrier displayed pronounced neuroinflammation, not previously described in association with PSEN1 mutations. Conclusion: Our findings are exceptional, as the PSEN1 G206R subject displayed an end-stage pathology of every common proteinopathy. It is unclear whether the observed alterations are caused by the mutation or are related to a cross-seeding mechanisms. The pronounced neuroinflammation in the index patient can be reactive to the extensive NC or a contributing factor to the proteinopathies. Thorough postmortem neuropathological and genetic assessment of subjects with familial AD is warranted, for further understanding of a dementing illness.
Hypothalamic Functional Connectivity and Apathy in People with Alzheimer’s Disease and Cognitively Normal Healthy Controls
Authors: Chaudhary Shefali , Zhornitsky Simon , Chao Herta H. , van Dyck Christopher H. , Li Chiang-Shan R.
Published: October 2022

Background: Earlier studies have described the neural markers of apathy in Alzheimer’s disease (AD) and mild cognitive impairment (MCI), but few focused on the motivation circuits. Here, we targeted hypothalamus, a hub of the motivation circuit. Objective: To examine hypothalamic resting state functional connectivity (rsFC) in relation to apathy. Methods: We performed whole-brain regression of hypothalamic rsFC against Apathy Evaluation Scale (AES) total score and behavioral, cognitive, and emotional subscores in 29 patients with AD/MCI and 28 healthy controls (HC), controlling for age, sex, education, cognitive status, and depression. We evaluated the results at a corrected threshold and employed path analyses to assess possible interaction between hypothalamic rsFCs, apathy and depression/memory. Finally, we re-examined the findings in a subsample of amyloid-β-verified AD. Results: AES total score correlated negatively with hypothalamic precuneus (PCu)/posterior cingulate cortex (PCC) and positively with left middle temporal gyrus (MTG) and supramarginal gyrus rsFCs. Behavioral subscore correlated negatively with hypothalamic PCu/PCC and positively with middle frontal gyrus rsFC. Cognitive subscore correlated positively with hypothalamic MTG rsFC. Emotional subscore correlated negatively with hypothalamic calcarine cortex rsFC. In path analyses, hypothalamic-PCu/PCC rsFC negatively modulated apathy and, in turn, depression. The model where hypothalamic MTG rsFC and memory independently modulated apathy also showed a good fit. The findings of diminished hypothalamic-PCu/PCC rsFC in relation to apathy and, in turn, depression were confirmed in amyloid-verified AD. Conclusion: The findings together support a role of altered hypothalamic connectivity in relation to apathy and depression, and modulation of apathy by memory dysfunction.
The Ethics of Using Caregivers as Cognitive Testers
Authors: Possin Katherine L. , Rosen Allyson C.
Published: October 2022

O’Caoimh et al. demonstrated that caregivers or family members could administer and score a brief cognitive screening instrument and detect cognitive impairment with comparable accuracy to similar measures administered in-person by trained staff. This novel approach challenges us to consider the boundaries of how caregivers or other family members are used in remote testing. We discuss the potential risks of administration bias, test integrity, and impacts on the patient and caregiver or family member, and we recommend further research before incorporating this practice into routine clinical or research use.
Data fusion method for wireless sensor network based on machine learning
Authors: Wu Mi
Published: October 2022

In order to improve the energy consumption balance between wireless sensor nodes and reduce the energy consumption of nodes in the process of data fusion, a machine learning based data fusion method for wireless sensor networks is proposed. Through the establishment and training of wireless sensor network model, the compressed sensing method is used to collect wireless sensor network data, and the multi-dimensional de aggregation class analysis algorithm is used to de duplicate the collected data. Using the spatial correlation between the data collected by multiple sensor nodes, the DCS method is used to process the abnormal data of WSN network. In order to eliminate the influence of measurement error on the fusion accuracy, the WSN network data is preliminarily fused by combining the adaptive theory with the batch estimation fusion algorithm. Based on the preliminary fusion results of WSN network data, the Bayesian inference method in machine learning algorithm is used to further fuse WSN network data. The experimental results show that the number of surviving nodes is large and the energy consumption is low when using this method for data fusion. The energy consumption between wireless sensor nodes has a certain balance, which proves that this method has a good data fusion effect.
RETRACTED: An unsupervised approach for personalized RHM with reduced mean alert latency
Authors: Marimuthu Poorani , Vaidehi V.
Published: October 2022

This article has been retracted. A retraction notice can be found at https://doi.org/10.3233/JIFS-219433.
Student Psychology based optimized routing algorithm for big data clustering in IoT with MapReduce framework
Authors: Shanmugam Gowri , Thanarajan Tamilvizhi , Rajendran Surendran , Murugaraj Sadish Sendil
Published: October 2022

Clustering plays a fundamental task in the process of data mining, which remains more demanding due to the ever-increasing dimension of accessible datasets. Big data is considered more populous as it has the ability to handle various sources and formats of data under numerous highly developed technologies. This paper devises a robust and effective optimization-based Internet of Things (IoT) routing technique, named Student Psychology Based Optimization (SPBO) -based routing for the big data clustering. When the routing phase is done, big data clustering is carried out using the Deep Fractional Calculus-Improved Invasive Weed Optimization fuzzy clustering (Deep FC-IIWO fuzzy clustering) approach. Here, the Mapreduce framework is used to minimizing the over fitting issues during big data clustering. The process of feature selection is performed in the mapper phase in order to select the major features using Minkowski distance, whereas the clustering procedure is carried out in the reducer phase by Deep FC-IIWO fuzzy clustering, where the FC-IIWO technique is designed by the hybridization of Improved Invasive Weed Optimizer (IIWO) and Fractional Calculus (FC). The developed SPBO-based routing approach achieved effective performance in terms of energy, clustering accuracy, jaccard coefficient, rand coefficient, computational time and space complexity of 0.605 J, 0.935, 0.947, 0.954, 2100.6 s and 72KB respectively.
Flow distribution optimization of parallel pumps based on improved mayfly algorithm
Authors: Hou Shuai , Yu Junqi , Su Yucong , Liu Zongyi , Dai Junwei
Published: October 2022

An improved mayfly algorithm is proposed for the energy saving optimization of parallel chilled water pumps in central air conditioning system, with the minimum energy consumption of parallel pump units as the optimization objective and the speed ratio of each pump as the optimization variable for the solution. For the problem of uneven random initialization of mayflies, the variable definition method of Circle chaotic mapping is used to make the initial position of the population uniformly distributed in the solution space, and the mayfly fitness value and the optimal fitness value are incorporated into the calculation of the weight coefficient, which better balances the global exploration and local exploitation of the algorithm. For the problem that the algorithm is easy to fall into the local optimum at the later stage, a multi-subpopulation cooperative strategy is proposed to improve the global search ability of the algorithm. Finally, the performance of the improved mayfly algorithm is tested with two parallel pumping system cases, and the stability and time complexity of the algorithm are verified. The experiments show that the algorithm can get a better operation strategy in solving the parallel water pump energy saving optimization problem, and can achieve energy saving effect of 0.72%  8.68% compared with other optimization algorithms, and the convergence speed and stability of the algorithm have been significantly improved, which can be better applied to practical needs.
Use of shear wave elastography to analyze the muscle structure in children with spastic cerebral palsy
Authors: Analan Pinar Doruk , Aslan Hulya
Published: October 2022

PURPOSE: In children with cerebral palsy (CP), gastrocnemius muscle spasticity may lead to pes equinus posture which causes insufficient ankle joint dorsiflexion for normal gait. The aim of this study was to analyze the stiffness of gastrocnemius and tibialis anterior muscles by shear wave elastography (SWE) in children with pes equinus deformity due to spastic CP. METHODS: 24 legs of 12 children (6 females and 6 males, mean age 45.8 months) with CP were prospectively included in the study. Tissue stiffness quantification with shear-wave velocity (SWV) was analyzed. RESULTS: The mean SWVs of the gastrocnemius and tibialis anterior muscles were 3.91±0.26 m/s and 2.67±0.18 m/s, respectively. The stiffness of the gastrocnemius muscle was significantly higher than the stiffness of the tibialis anterior muscle (p < 0.0001). There was no correlation between the stiffness of these muscles (r = 0.129, p > 0.05). CONCLUSION: Gastrocnemius muscles were stiffer than tibialis anterior muscles in patients with spastic CP. But stiffness between these muscles was not correlated with each other. Pes equinus may be related to stiff gastrocnemius in these patients. This study demonstrates the clinical potential for SWE as a non-invasive tool for analyzing calf muscle stiffness.
The challenge point framework to improve stepping reaction and balance in children with hemiplegic cerebral palsy: A case series study
Authors: Ashouri Somayeh , Letafatkar Amir , Thomas Abbey C. , Yaali Rasoul , Kalantari Minoo
Published: October 2022

PURPOSE: This study investigated the effects of the challenge point framework (CPF) to improve stepping reactions and enhance balance in children with hemiplegic cerebral palsy (HCP). The CPF relates practice variables to the skill level of the individual and task difficulty. METHODS: Nine children with HCP (age: 7.7±2.4 years) completed six weeks (12 sessions) of a CPF intervention which consisted of progressively fewer sets and repetitions of a stepping reaction task wherein participants sought to improve both step length and reaction rate. Stepping reaction (step length and reaction rate) to a balance perturbation in the anterior, posterior, and lateral directions and static and dynamic balance (via the Pediatric Balance Scale) were measured at baseline, a second baseline 3 weeks later, and post-intervention. Repeated measures ANOVAs determined within-group changes. Cohen’s d effect sizes were calculated. RESULTS: Participants improved balance (d = 0.948, p = 0.010), step length (forward d = 0.938, p = 0.002; backward d = 0.839, p = 0.001; and lateral d = 0.876, p = 0.002), and reaction rate (forward d = 0.249, p = 0.042; backward d = 0.21, p = 0.047; and lateral d = 0.198, p = 0.049). CONCLUSION: These findings indicate that children with HCP may benefit from completing a CPF program with a motor learning approach. This approach of retraining stepping reactions helped to improve static and dynamic balance. The CPF may aid progression of functional task training in children with HCP aged 4–12, though more studies with a long-term follow-up analysis are needed to confirm this result.
Time-matched accelerometers on limbs and waist in children with CP give new insights into real-life activities after botulinum toxin treatment: A proof of concept study
Authors: Gantelius Stefan , Vikerfors Sandra , Edqvist Josefin Jansson , von Walden Ferdinand , Hagströmer Maria , Pontén Eva
Published: October 2022

PURPOSE: This study aimed to explore the feasibility of using time-matched uniaxial accelerometers for measuring movement in daily life in children with cerebral palsy (CP) before and after botulinum toxin injections. METHODS: This observational study of clinical care with a pre-post design was set in the home and school environment. Participants included eleven children (4–13 years of age) with CP (GMFCS I-III). The children wore uniaxial accelerometers (ActiGraph, model GT1M) for 4 days on both wrists, the right ankle and around the waist before, 3 weeks and 3 months after BoNT-A injections in the legs. Five children also got BoNT-A in the most affected arm. All injections were given according to clinical indications and routine. The accelerometers were all time-matched to define ambulation, arm swing, voluntary activity of arms, and bimanual activity. The feasibility of wearing accelerometers with this setup was evaluated. A linear mixed model was used for analysis of the percentage time and at which intensity the different activities were performed. The confidence interval demonstrated any difference between the dominant and non-dominant arm. RESULTS: Time-matching of accelerometers placed on both wrists, the waist, and one ankle is a feasible method of registering ambulation, arm swing during gait, and arm movements while not ambulating. Before injections, the children spent 5.6% of their time ambulating. This value declined to 3.9% at 3 months. Contrary to clinical goals, arm movement did not increase after injecting the most affected arm with BoNT-A, however, injections may have decreased mirror movements, which are often bothersome for the child. CONCLUSION: A time-matched 4-accelerometer set-up is feasible in children with cerebral palsy. A future study including time-matched multi-axial accelerometers on all four limbs, could provide important information on the effect of BoNT-A in daily life.
The prediction and treatment of postpartum myofascial pelvic pain
Authors: Zheng Yuan-Yuan , Ni Le-Yi , Ni Fei-Fei , Wang Xiao-Qian , Chen Yu-Mei , Guo Min , Dong Xiao-Xia , Pan Qiong-Hui , Chen Cong
Published: October 2022

BACKGROUND: The clinical manifestations of myofascial pelvic pain (MFPP) are mainly acute or chronic muscle pain at one or more trigger points in the pelvic cavity or pelvic floor. OBJECTIVE: This study aims to explore the predictive value of pelvic floor myoelectric parameters with respect to MFPP and the effect of its clinical treatment. METHODS: Two hundred and one women followed up in the Wenzhou People’s Hospital 6–12 weeks postpartum between July 2020 and July 2021. They were divided into an MFPP group (n= 90) and a non-MFPP group (n= 102), but 9 MFPP patients without a pelvic floor electromyography evaluation were not included. The general demographic data and pelvic floor electromyography evaluation parameters of the two groups were compared; the related factors of postpartum women suffering from MFPP were analyzed, and a nomogram model of the postpartum risk of suffering from MFPP was established. The 99 patients with postpartum MFPP were divided into a treatment group (n= 10) and a control group (n= 89). The difference in visual analog scale scores between the two groups initially and after three months of treatment was compared to evaluate the effective remission rate of postpartum MFPP after treatment. RESULTS: A significant difference was observed in the relaxation time at the rapid contraction stage (z= 4.369, p< 0.05) and the tension contraction stage (z= 135.645, p< 0.01) between the MFPP group and the non-MFPP group. The nomogram model for predicting postpartum MFPP was established with nine variables as potential predictors. The calibration chart and C index of 0.68 (95% CI: 0.65–0.71) proved that the model had a certain degree of discrimination. The clinical decision-making curve showed that the model could increase the net benefit rate of patients. The pain relief rate in the treatment group was significantly higher than that in the control group (p< 0.01). CONCLUSION: There is a significant correlation between postpartum MFPP and relaxation time at rapid contraction stage and tension contraction stage. The risk prediction nomogram model of postpartum MFPP established with nine potential predictors has a certain prediction capability, and clinical treatment can effectively relieve MFPP in postpartum patients.
Study on the effective measurement area of an open-ended coaxial probe for the dielectric measurement of biological tissues
Authors: Zhang Liang , Liu Benyuan , Ji Zhenyu
Published: October 2022

BACKGROUND: The dielectric properties of tissues are very important physical factors for the investigation and application of bio-electromagnetism. However, the size of the active sample tissue is usually limited in actual measurement, making it difficult to meet the requirements of the existing high-frequency measurement methods, thus influencing the measurement results. OBJECTIVE: The present study aimed to systematically investigate the various factors influencing the effective measurement area of the open-ended coaxial probe, including the design size of the probe and the dielectric properties of the object to be measured. METHODS: The simplified material mixing model, in which several types of materials were set as the material under test (MUT) and the perfect conductor (PEC) was set as the specific material, was used in the simulation to study the effective measurement area of eight types of probes with different sizes for the dielectric measurement of different MUTs. Different concentrations of NaCl solutions and three types of coaxial probes were used in the actual measurement to verify the simulation results. RESULTS: According to the simulation results, the effective measurement area, especially the effective measurement radius, was closely related to the outer conductor radius of the probe. The effective measurement area of the probe decreased when the outer conductor radius of the probe reduced. Moreover, the change in the effective measurement area of the probe was independent of the MUT when the cross-sectional size of the probe was smaller than a certain threshold value. The experimental results also confirmed this conclusion. CONCLUSION: According to the research results, the independent variable dimension could be effectively reduced and the modeling difficulty was reduced when the analysis model of the effective measurement area of the probe was established.
A novel composite smeared finite element for mechanics (CSFEM): Some applications
Authors: Simic Vladimir , Milosevic Miljan , Milicevic Vladimir , Filipovic Nenad , Kojic Milos
Published: October 2022

BACKGROUND: Mechanical forces at the micro-scale level have been recognized as an important factor determining various biological functions. The study of cell or tissue mechanics is critical to understand problems in physiology and disease development. OBJECTIVE: The complexity of computational models and efforts made for their development in the past required significant robustness and different approaches in the modeling process. METHOD: For the purpose of modeling process simplifications, the smeared mechanics concept was introduced by M. Kojic as a general concept for modeling the deformation of composite continua. A composite smeared finite element for mechanics (CSFEM) was formulated which consists of the supporting medium and immersed subdomains of deformable continua with mutual interactions. Interaction is modeled using 1D contact elements (for both tangential and normal directions), where the interaction takes into account appropriate material parameters as well as the contact areas. RESULTS: In this paper we have presented verification examples with applications of the CSFEMs that include the pancreatic tumor tissue, nano-indentation model and tumor growth model. CONCLUSION: We have described CSFEM and contact elements between compartments that can interact. Accuracy and applicability are determined on two verification and tumor growth examples.
Association between the time of physical laboral activities and leisure over shoulder pain in fruitculture workers: A cross-sectional study
Authors: Batista Gabriel de Amorim , Locks Francisco , Beltrán Picón Sol Patricia , Correia Heloísa Jácome , Ferraz Zalane Cristina Marques , Pitangui Ana Carolina Rodarti , Cappato de Araújo Rodrigo
Published: October 2022

BACKGROUND: Fruitculture workers are exposed to shoulder pain disorders due to long working times in overhead activities. OBJECTIVE: This study aims to analyze the association between the time of physical work and leisure activities over the perception of shoulder pain intensity in fruit growing workers. METHODS: This is a descriptive and correlational cross-sectional study. The sample consisted of 180 fruit-growing workers. Multivariable logistic regression was used, with an estimate of the Odds Ratio (OR) and 95% confidence intervals. The dependent variable: Numeric Pain Rating Scale (NPRS) (0–10 points), was categorized as low and high, with cutoff points of NPRS > 3 and NPRS > 4, and was associated with the independent variables (level of physical activity, personal, labour and psychosocial). RESULTS: Workers which are insufficiently active in leisure time are more likely to report high-intensity shoulder pain, NPRS > 3 (OR: 2.39; p = 0.049) and NPRS > 4 (OR: 2.85; p = 0.036). In addition, working time in overhead activities is a risk factor for high-intensity pain for NPRS > 3 and NPRS > 4 (OR = 1.01; p < 0.001). Underweight and normal-weight workers were less likely to report shoulder pain in NPRS > 3 (OR = 0.35; p = 0.020) and in NPRS > 4 (OR = 0.20; p = 0.001). CONCLUSION: Fruit-growing workers had a high prevalence of severe shoulder pain. In addition, workers who are insufficiently active at leisure, overweight and obese are more likely to report severe pain. It was observed that overhead tasks increase the chances of reporting high-intensity shoulder pain among workers.
Post COVID-19 pandemic assessment of quality of life of dental students using the WHOQOL-BREF questionnaire
Authors: Bashir Raima , Alam Beenish Fatima , Nayab Talha , Fahim Faisal
Published: October 2022

BACKGROUND: COVID-19 bitterly jolted the lives of masses around the globe, and affected the physical, mental, health, and quality of life of majority of individuals. OBJECTIVE: The aim of the study was to assess the quality of life of dental students of public and private colleges and those residing in college accommodation and own home using the WHOQOL-BREF questionnaire. METHODS: This cross-sectional study was conducted amongst 402 dental students of a private and public university. Students’ t-test was used to compare the data. Relationship between gender, institute and accommodation (college accommodation or own home) was assessed by multiple linear regression. P-value of < 0.05 was taken significant. RESULTS: The participants rated their quality of life to be good (mean Score 3.99±SD 0.93) during the post COVID-19 pandemic, while satisfaction with health was neutral to satisfactory (mean Score 3.77±SD 0.87). A significant difference regarding physical health and social relationship domains was observed between the private and public university students. Significant differences in all domains of QOL was also reported among students living in own homes versus those students utilizing college accommodation. CONCLUSION: The post COVID-19 quality of life of dental students in both private and public institutes differed with respect to physical and environmental domains. The difference was more significant among the student living in college accommodation than those living at home, which underscores that effort should be made to facilitate the students to improve their the quality of life post pandemic so that they may be more focused on studies and perform better.
Lassa Fever cases suffer from severe under-reporting based on reported fatalities
Authors: Simons David
Published: October 2022

INTRODUCTION: Lassa Fever is a viral haemorrhagic fever endemic to eight West African countries. Symptomatic disease is expected to occur in 20% of those infected, transmission typically occurs from viral spillover from rodent hosts. The combination of limited access to diagnostics and access to healthcare means the true burden of this disease is unknown.

METHODS: The case fatality rate among confirmed, probable, and possible cases of Lassa Fever in endemic regions is expected to be around 15%. Here, annual reported cases and deaths have been used to estimate the case fatality rate, using three subsets of available data, to understand the scale of under-reporting of severe human cases.

RESULTS: 38 records of Lassa Fever reported cases and deaths were produced comprising 5,230 reported cases and 1,482 reported deaths from 7 countries. The estimated case fatality rate ranges from 16.5-25.6% (S.D. = 11.5-32.2%). The expected number of severe cases between 2012-2022 is 8,995 with currently reported numbers 58% of the expected.

CONCLUSION: This analysis highlights current uncertainty and systemic under-reporting of the morbidity and mortality burden of Lassa Fever in its endemic region and must be considered when discussing the epidemiology of this neglected tropical disease.
Nodulo-ulcerative syphilis – case report and the review of literature
Authors: Skiepko U , Serwin AB , Piłasewicz-Puza A , Flisiak I
Published: October 2022

ABSTRACT
We describe the case of tertiary syphilis involving the skin. The lesions had a nodular-ulcerative form, localized on both arms. The patient had high titers of treponemal and non-treponemal serological tests for syphilis and histopathological picture was indicative for nodulo-ulcerative syphilis. No cardiological, neurological or ophtalmological abnormalities were found. The patient was treated with 2.4 million units i.m. of benzathine benzylpenicillin three times at weekly intervals, according to European Guideline. Unfortunately, the patient was lost for scheduled follow-up. More than two years later the skin lesions healed completely leaving discrete scars and a four-fold decline in a titre of Venereal Disease Laboratory Test was noticed.

STRESZCZENIE
Prezentujemy przypadek pacjenta z kiłą trzeciego okresu z zajęciem skóry pod postacią kiły guzkowo-wrzodziejącej w obrębie kończyn górnych. Chory miał wysokie miana odczynów krętkowych i niekrętkowych i obraz mikroskopowy typowy dla tej postaci kiły. Pacjent otrzymał trzy dawki benzylpenicyliny benzatynowej, każda po 2,4 mln j. w odstępach tygodniowych, zgodnie z Zaleceniami Europejskimi. Niestety, nie zgłosił się do żadnej z wyznaczonych wizyt kontrolnych. Po ponad dwóch latach stwierdzono całkowite wygojenie zmian skórnych z pozostawieniem dyskretnych blizn oraz 4-krotny spadek miana odczynu VDRL.
Challenges in Communicating Climate Change to Extension Audiences
Authors: Monroe Martha C. , Bode Claire Layman , Megalos Mark A.
Published: October 2022

Media coverage of climate change can often leave the average person confused and unsure what to believe. However, as a trusted source of information and research, Extension has the opportunity to educate people about climate change and appropriate adaptation strategies in a scientific, unbiased way. This 5-page fact sheet outlines four challenges of climate change education. Written by Martha Monroe, Claire Layman Bode, and Mark A. Megalos, and published by the UF School of Forest Resources and Conservation, May 2015.
Florida Citrus Rootstock Selection Guide, 3rd Edition
Authors: Castle William S. , Bowman Kim D. , Grosser Jude W. , Futch Stephen H. , Graham James H.
Published: October 2022

Information about citrus rootstocks has become an important part of understanding and managing citrus greening (Huanglongbing or HLB). This selection guide covers 20 characteristics of 45 citrus rootstocks and explains its methodology in detail. This revised 3-page fact sheet was written by William S. Castle, Kim D. Bowman, Jude W. Grosser, Stephen H. Futch, and James H. Graham and published by the UF Department of Horticultural Sciences, May 2015.

SP248/HS1260: Florida Citrus Rootstock Selection Guide, 4th Edition (ufl.edu)
Vespiform Thrips Franklinothrips vespiformis Crawford (Insecta:Thysanoptera: Aeolothripidae)
Authors: Mao Runqian , Xiao Yingfang , Arthurs Steven P.
Published: October 2022

Franklinothrips vespiformis Crawford is a predatory thrips with a pantropical distribution. The distinctive red, humped-back larvae and fast-moving ant-like adults are predaceous on small arthropods. In addition to being easily mistaken for an ant, this beneficial thrips is unusual in that it constructs a silken cocoon within which it pupates. Males of this species are rare. This species is sold for use as a biological control agent in botanical gardens, zoos, interior landscapes, research greenhouses, nurseries with ornamental plants as well as outdoors in subtropical regions. This 4-page fact sheet was written by Runqian Mao, Yingfang Xiao, and Steven P. Arthurs, and published by the UF Department of Entomology and Nematology, March 2015. (Photo credit: Runqian Mao, UF/IFAS)

EENY621/IN1083: Vespiform Thrips Franklinothrips vespiformis Crawford (Insecta: Thysanoptera: Aeolothripidae) (ufl.edu)
Asian Horntail Eriotremex formosanus (Matsumura) (Insecta: Hymenoptera: Symphyta: Siricidae: Tremicinae)
Authors: Li You , Hulcr Jiri
Published: October 2022

Since it was introduced to North America, the Asian woodwasp has become the most common wood wasp in Florida. It is not considered an economically important pest because it only attacks dying or dead trees, but the species may someday prove to be a pest and its ecological impacts in North American forests remain unknown. This 4-page fact sheet was written by You Li and Jiri Hulcr, and published by the UF Department of Entomology and Nematology, June 2015. (Photo credit: You Li, UF/IFAS)

EENY 628/IN1095: Asian Horntail Eriotremex formosanus (Matsumura) (Insecta: Hymenoptera: Symphyta: Siricidae: Tremicinae) (ufl.edu)
Spondias Growing in the Florida Home Landscape
Authors: Crane Jonathan H. , Wasielewski Jeff
Published: October 2022

Spondias species (whose common names among English speakers include ambarella, Ataheite apple, mombins, and hog plums) are flowering trees native to tropical and subtropical regions. They are known for their sweet fruit and grow well in the warmest parts of Florida. This revised 8-page fact sheet discusses biology, distribution and uses, as well as guidelines for propagation and maintenance. Written by Jonathan H. Crane and Jeffrey Wasielewski, and published by the UF Department of Horticultural Sciences, April 2015. (Photo by Forest & Kim Starr, CC BY 3.0)

HS63/MG059: Spondias Growing in the Florida Home Landscape (ufl.edu)
Gastrointestinal Parasites of Farmed White-tailed Deer (Odocoileus virginianus) in Florida
Authors: Cottingham Sydney L. , Walden Heather D.S. , Wisely Samantha M. , Campos-Krauer Juan M.
Published: October 2022

White-tailed deer are susceptible to infection by numerous gastrointestinal parasites. Not all parasite infections cause clinical disease, but even subclinical gastrointestinal parasitism may reduce the health and productivity of infected deer.  An understanding of parasite epidemiology is critical to improving captive deer health through effective parasite control strategies. This publication will serve as a guide to common parasites of farmed white-tailed deer in Florida and will provide producers with recommendations for management of gastrointestinal parasites in farmed deer.
The Veil as a Literary Central Motif in Selected Works
Authors: MOLLAMEHMETOĞLU ÖZBAY Sinem
Published: October 2022

In this article, the veil was treated as a central theme in selected literary texts. For this purpose, autobiographical novels, youth literature and short stories were selected. All were examined for a veil motif by evaluating the perception in the individual works. In addition, the holy scriptures, the Torah, the Bible and the Koran were analyzed for veiling fundamentals. The veiling in the individual works was examined for religious backgrounds and the behavioral pattern of the respective perception was observed. During the analysis of the texts, theoretical methods such as hermeneutics, reception aesthetics, psychoanalysis and comparative studies were used. The main work of this study is Chador by Murathan Mungan, with which the remaining works have been compared. The aim of the study was to find an answer to the question of how veiling is treated in German-Turkish literature. In addition, it was examined whether the respective veiling in the works is really religious or just traditional or culturally justified.
Tena Štivičić’in Invisible Adlı Oyununda Göç, Yeni Irkçılık, Kültürel Kimlik ve Çokkültürlülük
Authors: ERCİŞLİ Nazan
Published: October 2022

Göç sorununun çokça tartışıldığı son yıllarda, İngiliz tiyatrosunun dikkat çeken oyun yazarlarından biri olan Hırvat asıllı Tena Štivičić bu sorunu ele aldığı Fragile (2007) ve Invisible (2011) isimli oyunları ile adından söz ettirmiş, bu oyunlar ile European Author’s Award ve Innovation Award gibi ödüllere layık görülmüştür. Yazar, bu makalede ele alınan Invisible adlı oyununda yirminci yüzyılın son çeyreğinden itibaren küreselleşen dünyamızın hızla değişen girift yapısında, uluslararası göç sorununu ekonomik, politik, kültürel ve psikolojik temelli olarak ele alarak göçmenlerin sorunlarını dile getirmeye çalışmıştır. Karakterlerin göç hikayelerini yirminci ve yirmi birinci yüzyılda meydana gelen savaş ve çatışmalara açık olmayan göndermelerde bulunarak ele alan yazar, aynı zamanda onların İngiltere’nin çok kültürlü ve kapitalist temelli toplumsal yapısı içerisinde kültürel kimlikleri ile var olma ve ayakta kalma savaşını çarpıcı bir şekilde ortaya koyar. Oyunda uluslararası göç sorununu ağırlıklı olarak kendilerini görünmez ve değersiz hisseden göçmenlerin perspektifinden yansıtmaya çalışan Štivičić, aynı zamanda sorunun diğer muhatabı olan İngilizlerin bakış açılarına da yer verir. Çalışmada, yazarın Invisible adlı oyunundan hareketle içinden çıkılması zor bir soruna dönüşen göç olgusu nedenleri ve sonuçları ile birlikte tartışılmaktadır. Göçmenlerin kimlik edinme süreçleri ve maruz kaldıkları ırkçı ve ötekileştiren muameleler Immanuel Wallerstein, Etienne Balibar ve Homi K. Bhabha gibi bazı kuramcıların görüşleri ışığında ele alınarak, Štivičić’in göç sorununun çözüm yollarına dair yaklaşımları incelenmektedir.
Toskana Elçisi Neri Giraldi’nin İstanbul’daki Maceraları (1598)
Authors: MERCAN Özden
Published: October 2022

Bu makalede Toskana Grandukalığının Osmanlı yönetimiyle 1598 yılında müzakere edilen ve başarısızlıkla sonuçlanan diplomatik girişimi ele alınacaktır. Mevcut literatürde müzakerelerin başarısız olmasının nedeni olarak Santo Stefano Tarikatına ait kadırgaların Doğu Akdeniz’de Osmanlı karşıtı faaliyetleri gösterilmiştir. Bu konu görüşmelerde öne çıkan meselelerden biri olsa da müzakerelerin başarısızlıkla sonuçlanmasında başka faktörler de etkin rol oynamıştır. Özellikle Toskana temsilcisi olarak İstanbul’a gönderilen Neri Giraldi’nin faaliyetleri bu anlamda önemlidir. Giraldi’nin Osmanlı yönetimi ve diplomatik uygulamaları konusundaki yetersiz bilgisi birtakım diplomatik krizlere yol açmış, görüşmelerin başarısızlıkla sonuçlanmasına neden olmuştur. Bu makale, çeşitli arşiv belgelerindeki bilgiler ışığında müzakere sürecini yeniden kurgulayarak, Toskana elçisinin Osmanlı başkentindeki maceralarına odaklanacaktır.
19. Yüzyılda Ürgüp’te Rumların Yaşadığı Mahallelerde Yer Alan Konutlar Üzerine Mimari Değerlendirme
Authors: DIRIK Aytülü , TEKİNALP Pelin
Published: October 2022

Kapadokya Bölgesinin önemli yerleşimlerinden biri olan Ürgüp, Nevşehir kent merkezinin 20 km doğusunda yer alır. Ürgüp yerleşimi tarih boyunca çok sayıda uygarlığa ev sahipliği yapmıştır. Tarihi Antik Çağ’a kadar uzanan bu yerleşimde, 1923 nüfus mübadelesine kadar Hristiyan ve Müslüman halk beraber yaşamıştır. Kapadokya Bölgesinde önemli bir nüfusa sahip olan Rum halk, arkalarında kültür mirası eserleri bırakarak göç etmişlerdir. Çalışmanın amacı, 19. yüzyılda Ürgüp yerleşiminde Rumların yaşadığı mahallelerde yer alan konutları sanat ve mimarlık tarihi açısından incelemek ve belgelemektir. Ürgüp yerleşiminin, iklim, doğal şartları, topografya, tarihi kent dokusu yanında Rumların kentle ilişkileri, sosyo-kültürel ve ekonomik durumları hakkında bilgi verilmiştir. Konutlar sanat ve mimari oluşum yönünden incelenerek 18 evin kataloğu hazırlanmıştır. İncelenen konutların plan özellikleri, cephe düzeni, bezeme özellikleri ve malzeme-teknik bakımından bir değerlendirmesi yapılarak bir sonuca varılmıştır. Çalışmada incelenen konutlar üzerinden belgeleme çalışması yapılarak konutların özgün durumları yansıtılmaya çalışılmıştır. Bu çalışma ile bölgede hızla devam eden restorasyon ve onarım çalışmalarına bir altlık oluşturulmuş ve konutların yöresel özellikler taşıdığı, özgün değerleri ile ortaya konulmuştur. Bölgede daha sonra yapılacak olan koruma ve restorasyon faaliyetlerinde altlık veri oluşturacaktır.
Çince Söz Diziminin Tipolojik Açıdan Rusça ve Kırgızca ile Karşılaştırılması
Authors: KESKİN Mesut
Published: October 2022

Dillerde tipolojik yönelimi belirlemede kullanılan cümle kalıpları aracılığıyla yapılan incelemede “VO” sıralamalı diller ile aynı grupta yer almış olan Çin dilinin “OV” sıralamalı diller ile daha benzer bir yapıya sahip olduğu gözlemlenmiştir. Bu nedenle çalışmamız Çin dilini tipolojik açıdan “OV” sıralamalı dil olarak kabul görmüş olan Kırgızca ve “VO” sıralamalı dil olarak kabul görmüş olan Rusça ile karşılaştırıp, dillerin tipolojik açıdan “OV” tip mi, yoksa “VO” tip mi olduğunu belirlemede kullanılan cümle kalıplarının geçerliliğini somut örnekleme yöntemi ile yeniden test etmiştir. Yapılan inceleme ile dillerin yönelimini belirlemede kullanılan kalıpların geçerli olduğu sonucuna varılmıştır. Çince tipolojik açıdan incelendiğinde “VO” tip bir dil olan Rusçadan farklı, “OV” tip bir dil olan Kırgızca ile daha benzer bir sıralamaya sahiptir. Bu da Çincenin fiil konumları açısından “VO” diller ile benzerlik gösteren ancak diğer cümle ögelerinin sıralamaları açısından “OV” tip bir dil olarak değerlendirilmesi gerektiğini açık bir şekilde göstermektedir. Çincenin “OV-VO” diller ile benzer ve farklı yönlerinin anlaşılması, Çince öğrenen her iki tip dilin kullanıcıları açısından oldukça önemlidir.
Obtenção de Nanoformulações do Tipo Microemulsão Objetivando a Biodisponibilização de Anacardium occidentale e sua Eficiência como Agente Antioxidante
Authors: Maciel M. A. M. , Gomes F. E. S. , Anjos G. C. , Dantas T. N. C. , Esteves A. , Echevarria A.
Published: October 2022

Dois diferentes tipos de sistemas microemulsionados (SME) foram obtidos utilizando-se uma mistura dos tensoativos Tween 80 e Span 20 (3:1), miristato de isopropila (IPM) como fase orgânica e água bidestilada (sistema SME-4) e com adição de etanol como cotensoativo obteve-se o outro sistema (SME-1). Estes sistemas foram obtidos objetivando-se otimizar a avaliação do potencial antioxidante de Anacardium occidentale. A ação antioxidante do extrato metanólico (MeOH) obtido das cascas do caule desta planta, bem como do óleo fixo (FO) e de uma fração rica em taninos (FT) provenientes deste extrato, foi avaliada utilizando-se como fonte de radical livre o 2,2-difenil-picril-hidrazila (DPPH). Em função da difícil solubilização de FT, a atividade antioxidante desta fração só foi avaliada após solubilização nos sistemas SME-1 e SME-4. Os resultados obtidos mostraram uma forte atividade antioxidante para o extrato MeOH (CE50= 42,47 ± 0,14 μg/mL) e para a fração FT solubilizada nos dois sistemas microemulsionados (CE50 = 39,27 ± 1,07 μg/mL e CE50 = 42,20 ± 5,20 μg/mL para FT-SME-1 e FTSME-4, respectivamente). O óleo fixo não apresentou atividade até a dose de 710 μg/mL. Estes resultados indicam que a atividade antioxidante do extrato metanólico de Anacardium occidentale está correlacionada com a presença de taninos. Em relação aos sistemas encapsuladores SME-1 (contendo o cotensoativo etanol) e SME-4 (ausência de cotensoativo), não foi observada interferência significativa destes sistemas, nos resultados observados para a atividade antioxidante de FT-SME-1 e FT-SME-4.
Fluoride Concentration in Tap Water from Different Regions in Thailand
Authors: Putraphan Boonsong , Nantanapiboon Dusit , Osathanon Thanaphum
Published: October 2022

Fluoride supplementation in drinking tap water is one of the well-known effective methods for dental caries prevention. However, overexposure to fluoride following excessive fluoride intake from drinking water leads to dental fluorosis. Therefore, the assessment of daily fluoride consumption is required to calculate the optimal fluoride intake. The present study investigated the fluoride concentration in tap water collected from different areas in Thailand. A total of 27 locations were selected. Three samples of tap water (500 mL each) were independently collected from one location. Each sample in the same location was collected from the same faucet of tap water and stored in different containers. The samples were collected by dental students or dentists who worked in the selected areas from March 2020 to June 2020. Briefly, the faucet was cleaned with the tap water and the water was run from the faucet for 1-2 mins. Then, water was collected in 500 mL bottles and immediately capped. Samples were then stored at room temperature in tightly sealed bottles until analysis. Findings showed that most samples contained fluoride at a concentration lower than 0.7 mg/mL. Further, the water pH was in the range of 6.81-8.37. These levels were lower than the cut-offs established by the World Health Organization (WHO) for maximum levels of fluoride and pH in drinking water. In conclusion, the present study demonstrated that fluoride levels in tap water from different regions in Thailand are lower than those recommended by WHO for fluoride levels in drinking water.
Feeding Plate Fabrication for Infants with Cleft Palate Congenital Disorder at Mitra Sejati Hospital Medan and Grandmed Hospital Lubuk Pakam
Authors: Chairunnisa Ricca , Syafrinani  , Rusdy Hendry
Published: October 2022

Cleft lip and palate (CLP) are one of the birth defects commonly found in Medan and surrounding areas with approximately 150 cases handled annually at Mitra Sejati and Grand Med Hospitals. Generally, labioplasty surgery is the only given treatment, but fabrication of the feeding plate before or after surgery is important to cover the palatal defect. From the prosthodontics aspect, fabrication after surgery cannot be performed because most parents do not know the importance of the feeding plate. To overcome this problem, community service was conducted by fabricating feeding plates that will be given 1 week after surgery. This was achieved by getting information about patients with CLP, general examination by paediatricians, the impression of the oral cavity in the operating room before surgery, outline design, and feeding plate fabrication at the dental laboratory. Subsequently, the insertion was carried out to evaluate whether infants can drink normally using a bottle. A total of 18 infants with CLP recognized the benefits of the feeding plate in Mitra Sejati and Grand Med Hospitals. The education given had a positive effect on knowledge about the importance of feeding plate and motivation for its use to make infants drink normally and gain weight according to age.
Analyses of Bioactive Compounds of Pegagan (Centella Asiatica (L.) Urb) from Samosir – Indonesia Accession
Authors: Vinolina Noverita Sprinse , Sigalingging Riswanti
Published: October 2022

Centella Asiatica or Pegagan is classified as one of the wild plants that has not been domesticated. The excessive usage of this plant in traditional and modern medicinal applications threatens its population and sustainability. Thus, to preserve the plant and supply the high request of this plant in agromedicinal industry, studies concerned with the growth and bioactive compounds of Pegagan cultivated under commercial field conditions are urgently needed. This study purposed to examine the bioactive components of Pegagan (especially in leaves and roots) under field conditions, including asiaticoside, madeccasoside, and Asiatic acid. The Pegagan was harvested weeks after planting (WAP). The wet and dry weights of the leaves and roots were weighted and subsequently measured for their centelloside compounds by Thin-Layer Chromatography (TLC) procedure. The results revealed that the resulting asiaticoside content in the roots (1.25%) was higher than in the leaves (0.88%). The same results were achieved for the madecassoside content where the madecasosside content in the roots was 2.23%, while the content in the leaves was 2.11%. However, contrarily, the Asiatic acid compound in the leaves was 1.10% higher than the content in the roots (0.60%). It might be attributed to a longer period of field cultivation of Pegagan that delivered adequate time for the plant to alter Asiatic acid to asiaticoside and madecasosside at a later developmental growth. Moreover, these discoveries are advantageous in defining the most proper harvest time for commercial field cultivation of Pegagan to yield the highest amount of certain centelloside compounds.