bluuebunny/crossref_metadata_2025 huggingface dataset:
Geç Antik Çağ Amphoralarında Görülen Yazıt ve Mühürler Işığında Annona Sistemi: LRA 1, LRA 2, LRA 3 ve Zeest 80
Authors: KARA Ülkü
Published: June 2021

Doğu Roma İmparatorluk Dönemi ekonomisinde uygulandığı sanılan ve artık varlığı pek çok araştırmacı tarafından kabul edilen, vergi toplama ve ayni dağıtma sistemi olan annonanın (annona civicia ve annona militaris) eylemlerinden biri “ürünün yer değiştirmesi/nakliyesi”dir. Vergi karşılığında toplanan ürünlerin denizaşırı ve uzak coğrafyalara aktarılması gibi önemli bir organizasyonda kullanılan amphoralar, kabın temin edilmesinden ürünün bozulmadan varışına kadar geçen süreçte oldukça önemlidir. Ayrıca, amphoranın formu kadar üzerindeki yazıtlar ve mühürler de kabı temsil eden öğelerdendir. Sözü edilen mühür ve yazı biçimleri (graffito ve dipinto) dönemin ekonomik, din ve dil özelliklerini yansıtmasının yanı sıra, annnona sisteminin uygulamaları olarak da kabul edilmektedir. Sunulan çalışmada; Doğu Roma İmparatorluğu’nun Geç Roma – Erken Bizans Dönemi boyunca annona organizasyonuna yönelik üretildiği sanılan ya da bunun için kullanıldığı düşünülen ve Akdeniz çevresinde yoğun olarak yayılım gösteren dört amphora tipi (LRA 1, LRA 2, LRA 3 ve Zeest 80); formları, üretimleri ve üzerinde görülen yazıt ve mühürler özelinde ele alınmış ve annona sistemi içinde yer alıp almadıkları irdelenmiştir.
Legislative regulation of the results of research and experimental design works
Authors:   Federal Governmental Institution «Scientific Research Institute of Information Technologies of the FPS of Russia, MOSHNYAKOVA YANA I. , KORNILOVA YULIA A. ,   Federal Governmental Institution «Scientific Research Institute of Information Technologies of the FPS of Russia, RYABOVA NATALIA V. ,   Federal Governmental Institution «Scientific Research Institute of Information Technologies of the FPS of Russia, KOZLOV YURI D. ,   Federal Governmental Institution «Scientific Research Institute of Information Technologies of the FPS of Russia
Published: June 2021

The presented article studies the issues of accounting the results of research and development work in the institutions of the penal system. The purpose of the study is to refer to the official scientific and technical information of the penal system as an object of legal regulation. The scientific and practical significance of the work lies in its subsequent applicability in the legal regulation of activities in organizations. The research is based on the empirical method of cognition. The descriptive method of normative legal documents regulating the scientific activity in the penal system is used. The authors of the article summarize the need to create a unified database of research and development activities in the Service. The practical value of the materials presented in this article lies in the possibility of creating on their basis a single database for accounting the results of intellectual activity. Internal accounting of scientific and technical documentation will optimize the planning and control of research and development work, increase the volume of implemented developments, and expand the opportunities for exchange of experience. The creation of a departmental automated system operating on the basis of quantitative indicators, as a result, will help to improve the quality of scientific support and the efficiency of the entire penitentiary system. Key words: scientific activity, scientific and technical activity, scientific and technical information, scientific and technical result, state regulation, results of scientific and technical activity, the result of intellectual activity.
Extracts of herbs and alcohol increase vase life of Dianthus caryophyllus L. cv 5 ‘Yellow Candy’
Authors:   Islamic Azad University, Hashemabadi Davood , Abedini Aboksari Hassan ,   Islamic Azad University, Hedayat Rad Donya ,   Islamic Azad University, Kaviani Behzad ,   Islamic Azad University
Published: June 2021

Some chemicals such as 8-HQS used for prolonging the vase life of cut flowers are harmful to human health. Therefore, it is necessary to identify natural compounds to delay senescence and tissues destroying of cut flowers. Essential oils with antimicrobial properties can have a significant effect on the vase life of cut flowers without any problems. The effect of dill (Anethum graveolens), geranium (Pelargonium graveolens) and caraway (Cuminum cyminum) essential oils and alcohol on the vase life of Dianthus caryophyllus L. cv ‘Yellow Candy’ were investigated. Gas Chromatography/Mass Spectrometry (GC/MS) analysis of the essential oils showed that the highest percentage of essences in geranium (13.03 %), caraway (26.05 %) and dill (52.23 %) were geraniol, methyl-3-phenyl-2-propenal and linalool, respectively. Vase life was increased to 15.43 and 15.11 by using 100 mg·L-1 dill and 50 mg·L-1 28 geranium essential oil solutions, respectively. Solution uptake (2.18 mL·g-1 FW) and the activity of catalase (1.78 µg·g-1 29 FW) were also highest in 100 mg·L-1 dill essential oil solution compared to distilled water (1.07 mL·g-1 30 FW and 0.90 µg·g-1 FW, respectively). In conclusion, the 2 % alcohol, 100 mg·L-1 dill, 50 mg·L-1 31 geranium, and 100 mg·L-1 32 cumin induced the highest vase life. Therefore, dill essential oil (at a concentration of 100 mg·L-1 33 ) is introduced as the most appropriate, effective and safest treatment.
РАСПРЕДЕЛЕНИЕ ДОХОДОВ И РАСХОДОВ В БЮДЖЕТНЫХ ОРГАНИЗАЦИЯХ
Authors: Гулиева Сaадат
Published: June 2021

В условиях постоянно растущей рыночной экономики и научно-технического прогресса чрезвычайно важна проблема повышения качества, развития и управления бюджетными организациями, а также совершенствования бюджетных доходов и расходов, которая лежит в основе общей проблемы. Проблема повышения эффективности финансирования бюджетных организаций выходит на первый план. В данной статье как один из эффективных механизмов управления расходованием средств, выделенных из государственного бюджета, рассматривается группировка расходовбюджетов всех уровней и подробно рассматривается их группировка по экономическому содержанию. Цель – рассмотреть доходы и расходы государственного бюджета и определить, как они распределяются в бюджетных организациях. Методология – теоретическое исследование. Результат – выявлены источники формирования средств в бюджете и определить статьи затрат в зависимости от экономического содержания.
ТЕОРЕТИЧНІ ПІДХОДИ ДО ВИЗНАЧЕННЯ ТА СИНХРОНІЗАЦІЇ СВІТОВИХ ЕКОНОМІЧНИХ ЦИКЛІВ
Authors: Галуцьких Наталія , Кошкарьова Єлизавета , Чорна Анна
Published: June 2021

В статті розглянуто категорія «економічні цикли» та їх основні чотири фази. Проведено детальний аналіз сучасних підходів до визначення категорії «економічні цикли» з застосуванням ретроспективного методу. Розглянута класифікація та сутність економічних циклів. Визначено різноманітність видів економічних циклів, які мають значення як у теорії, так і на практиці.
ACCOUNTINGS AND FINANCIAL REPORTINGS REFORM IN THE GEORGIAN PUBLIC SECTOR
Authors: Grigalashvili Levan , Grigalashvili Bidzina
Published: June 2021

The paper includes a retrospective review of the reformation of accounting and financial reporting of the public sector of Georgia. The modern state of regulation of this particular field is analyzed and existing disadvantages are emphasized. Also, based on the analysis, proposals in regards to perfecting the accounting and the financial reporting in the public sector are developed.
MODERN CONDITIONS FOR SOFT SKILLS FORMATION AMONG STUDENTS OF SOCIONOMIC PROFESSIONS
Authors: Tokaruk L. , Vasylieva-Khalatnykova M. , Muzyka O.
Published: June 2021

Modern higher professional education only stands on the threshold of reforms, related to the educational guidance aimed at the development of soft skills which are in demand in the international labour market. The basis of modernization consists of innovative transformations of constituents of the educational system, including continuous on-line education, blended learning. The development of universal «Soft skills» among the students of socionomic professions enables developing in a professional direction, building a career, and afterwards getting work in a successful organization.
КОРИГУЮЧА ГІМНАСТИКА З ЕЛЕМЕНТАМИ ПОСТІЗОМЕТРИЧНОЇ РЕЛАКСАЦІЇ ПРИ ШИЙНОМУ ОСТЕОХОНДРОЗІ ХРЕБТА
Authors: Грейда Наталія , Андрійчук Ольга , Ульяницька Наталія , Кренделєва Венера
Published: June 2021

В статті дано рекомендації застосування коригуючих вправ на розслаблення м’язів, вправ на координацію, динамічних вправ з обмеженою амплітудою, статичних і спеціальних дихальних вправ та діафрагмального дихання, вправ на зміцнення м’язів шиї і тулуба та основних технічних прийомів постізометричної релаксації при шийному остеохондрозі хребта. Автором обґрунтовано ефективність застосування коригуючої гімнастики з елементами постізометричної релаксації при шийному остеохондрозі хребта на основі ортопедичних методів дослідження.
MEASUREMENT ERRORS AFFECTING THE CHARACTERISTICS OF MULTI-POSITION SYSTEMS, AND WAYS TO REDUCE THEM
Authors: Аrtikula Andriy , Britov Dmytro , Dzhus Volodymyr , Haibadulov Borys , Haibadulova Anastasiia , Herasymov Serhii , Kaluhin Denys , Kukobko Serhii , Roshchupkin Yevhen , Tytarenko Roman
Published: June 2021

Modern wide development of science and technology causes the growth of information needs in all branches of human development. At present, there are all opportunities to increase information security by combining sources of information into a single system. At the same time, when merging, specific difficulties and features emerge, which together make it difficult to implement the proposed solutions. The paper considers the peculiarity of combining different types of radar stations into a single information system. Errors of measurements of separate parameters and their influence on system characteristics are considered. Options for solving the problems that have arisen are proposed.
Análisis descriptivo de 105 pacientes con linfoma de células T tratados en un centro de cuarto nivel en Cali (Colombia) entre los años de 2007-2013.
Authors: Díaz Correa Laura María , Jaramillo Echeverri Francisco , Silva Pérez Nora , Restrepo Molina Juan Guillermo , Rosales Martínez Joaquín Donaldo
Published: June 2021

Introducción y objetivos. Los linfomas T representan el 10%-12% de todos los linfomas no Hodgkin. Actualmente no se conocen claramente razones por las cuales tienen mal pronóstico y pobre respuesta al tratamiento convencional. El objetivo es describir una cohorte con diagnóstico de linfoma T tratada en la Fundación Valle del Lili (Cali) período 2007-2013.
Caracterización de los pacientes con diagnóstico de linfoma B difuso de célula grande (LBDCG) en el Instituto Nacional de Cancerología.
Authors: Ospina Idárraga Juan Alejandro , Enciso Olivera José Leonardo
Published: June 2021

Introducción y objetivos. Los LBDCG son los linfomas no Hodgkin más frecuentes en adultos. No existen estudios en nuestra población que caractericen pacientes con esta enfermedad. El objetivo fue la caracterización clínica, histopatológica e inmunofenotípica de la población con LBDCG diagnosticada y tratada en la institución desde enero de 2009 hasta diciembre de 2013.
Supervivencia de cáncer de mama operable.
Authors: Ramos Guette Pedro
Published: June 2021

Introducción y objetivos. El propósito de este estudio fue evaluar supervivencia libre de enfermedad y global en pacientes mujeres con cáncer de mama operable.
Cáncer de colon temprano en un paciente con bacteriemia por Streptococcus bovis : reporte de un caso y revisión de la literatura.
Authors: Bonilla González Carlos Eduardo , Velásquez Juan Carlos , Galvis Gómez Luisa Alejandra , Pinilla Paola Andrea
Published: June 2021

Introducción y objetivos. Se ha descrito una estrecha relación entre la bacteriemia por Streptococcus bovis y tumores de colon. A pesar de la recomendación de numerosos estudios clínicos acerca de la necesidad de realización de colonoscopia entre los pacientes que presentan ya sea bacteriemia o endocarditis por Streptococcus bovis, por su vinculación con tumores colónicos, esta asociación no ha sido constante, debido a la no discriminación entre diferentes biotipos y al requerimiento del examen colónico completo.
Mesotelioma pericárdico : reporte de caso clínico y revisión de la literatura.
Authors: Quiroga Echeverri Alicia , Durango Isabel Cristina , Holguín Cardona Andrea
Published: June 2021

Introducción y objetivos. Los tumores que comprometen el pericardio son poco frecuentes, detectándose del 1% al 20% de las autopsias realizadas a pacientes con cáncer. El mesotelioma pericárdico primario es una de las neoplasias más raras teniendo en cuenta estadísticas generales, aunque ocupa el tercer lugar entre los cánceres con origen cardíaco primario. Se lleva a cabo una revisión de la literatura y se reporta el caso de un paciente.
Meduloblastoma de alto riesgo en recaída con respuesta favorable a un análogo de somatostatina (octreótido) : reporte de un caso.
Authors: Bonilla González Carlos Eduardo , González Ramírez Diego Mauricio , Galvis Gómez Luisa Alejandra
Published: June 2021

Introducción y objetivos. El meduloblastoma cerebeloso en adultos es una enfermedad infrecuente, por lo que la mayoría de los datos del tratamiento de las recaídas se basa en series y reportes de casos de centros de referencia. Se ha identificado expresión de receptores de somatostatina en la mayoría de casos de meduloblastoma y algunas experiencias preclínicas han mostrado respuesta a los análogos de somatostatina.
Análisis de supervivencia de cáncer de seno en un centro oncológico de Bogotá (2005-2013).
Authors: Zuluaga Liberato Andrea Marcela , Zuluaga Cristancho Eduardo Alirio
Published: June 2021

Introducción y objetivos. El cáncer de seno es el cáncer más común en mujeres en el mundo, por eso es importante identificar los determinantes de su pronóstico. Determinar cómo el estadio de la enfermedad al diagnóstico, la presencia de receptores hormonales y la sobreexpresión de HER2 afectan la sobrevida libre de la enfermedad y la sobrevida global.
Supervivencia de siete años de adenocarcinoma de pulmón : reporte de un caso.
Authors: Bruges Ricardo , Pisciotti Iván
Published: June 2021

Introducción y objetivos. El cáncer de pulmón es la segunda causa de mortalidad entre las mujeres, con supervivencia promedio de 60 meses en estadios tempranos y menos de 12 meses para estadios avanzados.
Análisis de flujos, tiempos de espera y capacidades en el área de quimioterapia del Centro Javeriano de Oncología.
Authors: Ruiz Patiño Alejandro , Rojas Puentes Luis Leonardo , Acosta Ospina Laura Elena , Natera Annie
Published: June 2021

Introducción y objetivos. Evaluar la capacidad instalada, los tiempos de espera para inicio y el tiempo de ingreso de pacientes en tratamiento en la Unidad de Quimioterapia del Centro Javeriano de Oncología (CJO).
Identificación de las necesidades de atención de pacientes en un programa de trasplante de células tronco hematopoyéticas.
Authors: Orozco Oviedo Carlos A. , Olmos Grings Cristiane , Zuckemann Joice , Reichert Andressa , Oliveira da Silva Priscila , Della Costa Rigoni Lisandra , Dalmolin Gabriela , Keller Jochims Ana Maria , Esteves Daudt Liane
Published: June 2021

Introducción y objetivos. Identificar y analizar las necesidades de atención de los pacientes candidatos a trasplante de células tronco hematopoyéticas (TCTH) con el fin de planificar las intervenciones para cada situación específica en el Programa Asistencial de Trasplante de Células Tronco Hematopoyéticas (PATCTH).
Leucemia y linfoma de células T del adulto y virus HTLV-I en Colombia (Suramérica) : reporte de dos casos y revisión de la literatura.
Authors: Huertas Gamboa José Fernando , Guerrero Villota Álvaro Jaime , Gómez Rigoberto , Gómez Álvaro , Herrera Juan Manuel , Idrobo Henry , Hernández Indira , Saavedra Miguel Ángel
Published: June 2021

La leucemia/linfoma de células T (ALLT) es un raro desorden linfoproliferativo que fue descrito como una entidad distinta en 1977, en Kioto (Japón). El virus linfotrópico tipo I HTLV-I está implicado en la patogénesis desde que fue reportado en áreas del mundo donde es endémico. El 2% de los pacientes infectados con HTLV-I desarrollan ALLT a través del tiempo y el 95% de los pacientes con ALLT muestran evidencia serológica de HTLV-I. La ALLT muestra cuatro formas: aguda, linfomatosa, crónica e indolente. La forma aguda es muy común y tiene un curso agresivo con una sobrevida de 6-10 meses sin tratamiento.
Leucemia promielocítica aguda : experiencia en un centro.
Authors: Cortés M. , Sarmiento I. C. , Linares A. , Aristizábal M. P. , Castaño S. , Cabrera E. , Ortiz F. , Beltrán E.
Published: June 2021

Introducción. Los pacientes con leucemia promielocítica aguda (LPA) pueden lograr altas tasas de curación con tratamientos adaptados al riesgo. Objetivo. Conocer los resultados con protocolo de quimioterapia Pethema adaptado a un país en vía de desarrollo.
Asociación entre herpes zóster cutáneo y recaída o progresión del cáncer.
Authors: Alarcón Tarazona M. L. , Esper Rueda J. A. , Alzate Amaya F. , Fajardo J. E. , Insuasty Enríquez J. S.
Published: June 2021

Objetivo. Determinar la asociación entre la aparición de herpes zóster y posterior recaída o progresión de neoplasia sólida.
Rabdomiosarcoma embrionario prostático en adultos : a propósito de un caso.
Authors: Contreras Borrego Eusebio Enrique , Estrada López Haroldo
Published: June 2021

Objetivo. Describir las características clínicas, estudios diagnósticos, aspectos quirúrgicos y radioterápicos de un paciente adulto con rabdomiosarcoma embrionario prostático.
La academia en oncología y hematología a través de nuestra publicación.
Authors: Manneh Raimundo
Published: June 2021

El aumento progresivo de la incidencia del cáncer, su mortalidad y el número de personas que viven con diversas neoplasias activas o no, crece en más del 3% cada año. Esta cifra es un testamento vívido del avance de la investigación clínica y de transferencia que en la actualidad suman cerca del 30% del producto intelec-tual global en diferentes áreas biomédicas. No obstante, el aporte de América Latina ha sido escaso, y sigue  una  tendencia  lenta,  limitada  por  la  carencia  de  recursos;  en  concordancia,  Colombia  continúa situando sus objetivos en investigación alre-dedor de las enfermedades transmisibles, a pesar de la rápida transición epidemiológica que modifica estre-pitosamente el comportamiento de las enfermedades crónicas,  incluyendo  las  alteraciones  hematológicas  benignas y malignas, y el cáncer
Investigación clínica en hematología y oncología en América Latina.
Authors: Cardona Andrés Felipe , Rivera Diana , Acevedo Andrés
Published: June 2021

En general, se considera que la contribución de América Latina a la producción científica global es baja, incluyendo la generación de conocimiento en áreas sensibles de la hematología y la oncología. Un análisis bibliométrico de la geografía relacionada con la produc-ción literaria, presentada en las reuniones anuales de la Sociedad Americana de Oncología Clínica (ASCO, por su sigla en inglés), indicó que cerca de la mitad de los resúmenes provienen de los Estados Unidos; de igual forma, el estudio documentó que cerca del 20% de los países latinoamericanos en dicha conferencia cada año producen más del 90% de los estudios aceptados1. El mejor representante de nuestro entorno fue Brasil, que constituyó el 1.1% (IC 95% 0.34% - 1.46%); tal cifra fue inferior a lo reportado por China, Corea del Sur, Canadá, España, Francia, Alemania, Japón, Italia y Estados Unidos.
Uso del catéter subcutáneo (CS) en el programa de cuidado paliativo domiciliario de la Fundación Santa Fe de Bogotá.
Authors: Camacho María Isabel , Acevedo Andrés , Santacruz Juan Guillermo , Castro Carlos , Becerra Henry , Cardona Andrés Felipe
Published: June 2021

Introducción: Los catéteres subcutáneos (CS) constituyen una herramienta útil para facilitar el manejo domiciliario de los pacientes con enfermedad oncológica o crónica terminal. Materiales y métodos: El presente estudio refleja los resultados de un registro ambidireccional que inició la recolección de información sobre el uso domiciliario de CS en una población de pacientes en cuidado paliativo (CP) a partir de julio del 2009 y hasta diciembre del 2010. Las variables incluidas hicieron referencia a las características demográficas de la población, los motivos y el perfil de uso de los CS y sus complicaciones. Cada evento (colocación de un CS) fue registrado de forma independiente (aunque correspondieran a un solo paciente). Resultados: En total, se realizaron 140 intervenciones en 66 pacientes que tuvieron una edad promedio de 64 años (+/-16) y una distribución equitativa según el sexo. El 71% de los sujetos tenía un índice de Karnofsky < 50% y tan solo el 16% estaba en tratamiento oncológico activo, siendo más frecuente entre los hombres (p < 0.05) y en aquellos con menor compromiso funcional (p < 0.05). Los diagnósticos oncológicos más frecuentes fueron los tumores de origen gastrointestinal (28/42%), del tracto genitourinario (12/18%) y los primarios de cabeza y cuello (5/8%). La principal indicación para la colocación del CS fue la administración de analgésicos opioides y no opioides (87%), seguido por el manejo de náuseas y vómito (32%). El tiempo promedio de uso del CS fue de 15.8 días (+/-11), el sitio más utilizado fue la región infraclavicular (64%) y el motivo principal para su instauración fue la administración de medicamentos (95%). En general, el objetivo terapéutico se logró en el 92% de los casos; en la población restante, el fin no se alcanzó por ser el control de disnea tumoral (4/5 casos con cáncer de pulmón). La tasa de complicaciones fue del 35% en 128 casos evaluables. Los eventos adversos se asociaron con la administración concomitante de quimio y/o radioterapia (p = 0.03), con la infusión continua de opioides potentes (p = 0.03), cuando el motivo primario fue la analgesia (p = 0.006) y cuando el CS duró menos de 15 días (p = 0.003). Conclusión: El CS es una estrategia de manejo integral para el paciente que se encuentra en CP domiciliario con una elevada razón entre el beneficio y el riesgo.
Genotipo complejo en un paciente con GIST.
Authors: Becerra Henry , Cardona Andrés Felipe , Acevedo Andrés , Vargas Carlos , Carranza Hernán , Otero Jorge , Álvarez Johanna , Aguirre Diego , Serrano Silvia , Zuluaga Alirio
Published: June 2021

Se presenta el caso de un hombre de 35 años diagnosticado de un tumor del estroma gastrointestinal (GIST) localizado en el yeyuno proximal y estratificado como de alto riesgo, en quien se resecó el primario sin evidencia de recaída, hasta documentar múltiples lesiones hepáticas, por lo que inició imatinib (Glivec®) 400 mg/día. Después de encontrar progresión, se aumentaron las dosis del inhibidor sin respuesta, por lo que inició sunitinib (Sutent®) 50 mg/día con el mismo resultado. Posteriormente, se realizó una reevaluación del histotipo y genotipificación, encontrando positividad para la mutación del exón 9 del gen KIT. A partir de noviembre del 2009, se administró sorafenib (Nexavar®) 400 mg cada 12 horas, logrando una respuesta metabólica superior al 50% (evaluada por tomografía por emisión de positrones –PET/TAC–) y parcial siguiendo los criterios descritos por Choi y colaboradores. Durante el tratamiento de tercera línea, se efectuó una nueva biopsia del tumor, que demostró un genotipo complejo, incluyendo la mutación V600E del BRAF, y manteniendo el beneficio clínico con la intervención descrita hasta julio del 2011; en el momento, el paciente continúa vivo. A continuación, se plantea un análisis de los mecanismos moleculares que explican la resistencia a los inhibidores de tirosina-quinasa y las implicaciones sobre la terapéutica del GIST.
Tumor teratoide rabdoide atípico en un adulto joven.
Authors: Quintero Carlos Andrés , Castro Christian , Hakim Fernando , Useche Nicolás , Mejía Marcela , Flórez Adriana , Bermúdez Sonia , Velandia Fernando , García Alfredo , Ortiz León Darío , Cardona Andrés Felipe
Published: June 2021

Se presenta el caso de un hombre de 28 años con pérdida progresiva de la agudeza visual y cefalea asociada a polidipsia, poliuria e hipersomnia. La resonancia magnética cerebral mostró una masa heterogénea localizada a nivel selar/supraselar con realce intenso después de la administración del contraste. Se realizó una resección parcial con patología que evidenció una lesión tumoral de apariencia rabdoide con pérdida de la expresión del INI-1. Estos hallazgos fueron compatibles con un tumor teratoide/rabdoide atípico tratado con teleterapia y el esquema de quimioterapia ICE con adecuada respuesta. Se discute el resultado después de cinco meses de tratamiento en espera de la administración de quimioterapia con intensidad de dosis más rescate con progenitores obtenidos de sangre periférica. También se presenta una revisión de los datos referentes al manejo de esta neoplasia, al igual que de los mecanismos moleculares implicados en su fisiopatología.
¿Cómo quedamos los pacientes frente a la nueva reforma del sistema de salud?
Authors: Ramírez Laura , Garzón Adriana María
Published: June 2021

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Nuevas perspectivas moleculares para el tratamiento de los meningiomas anaplásicos recurrentes : a propósito de un caso.
Authors: Behaine José M. , Mejía Juan Armando , Useche Nicolás , Bermúdez Sonia , Cardona Andrés Felipe
Published: June 2021

Se reporta el caso de una mujer de 53 años con un cuadro clínico de corta evolución consistente en cambios comportamentales que se asoció con alteración del afecto y de la atención, por lo que se diagnosticó un meningioma de alto grado frontal izquierdo, que requirió manejo quirúrgico en tres oportunidades, radioterapia y dos líneas de tratamiento médico (hidroxiurea e imatinib) sin respuesta; ante la evidente progresión de la enfermedad, se decidió administrar octreotide más everolimus, intervención dirigida contra la expresión anormal de receptores de somatostatina tipo 2 y la disfunción molecular de la vía de señalización PIP3K/mTOR/AKT. Con dicha intervención, se alcanzó respuesta parcial.
A importância das atividades carnavalescas na vida dos idosos
Authors: De Magalhães Arena Corrêa Matilde Maria , Simson OlgaRodrigues de Moraes von
Published: June 2021

O presente artigo se refere aos idosos participantes de escolas de samba do interior paulista: uma de Campinas, a Rosa de Prata, e a outra de Duartina, Unidos da Vila. Nesta pesquisa, foram realizadas entrevistas que tinham como objetivo demonstrar através de trechos das narrativas dos colaboradores suas atividades carnavalescas e o quanto isso pode ter contribuído com o envelhecimento bemsucedido,teoria no campo da Gerontologia, que considera vários aspectos como: a subjetividade dos idosos, sua autopercepção, características culturais e, principalmente, que o bem-estar na velhice não é responsabilidade apenas individual, mas coletiva. A pesquisa se utilizou da História Oral no campo das artes, com entrevistas que foram gravadas e transcritas, e também do recurso de imagens fotográficas.
Grandmas Project: memória e afeto na cozinha
Authors: Mazzucchi Ferreira Maria Leticia
Published: June 2021

Neste artigo é proposta a análise de narrativas orais de mulheres idosas através do programa Grandmas Project, que consiste em filmes de 8 minutos feitos por netos junto às suas avós executando receitas que estejam associadas às suas trajetórias biográficas. No encontro intergeracional entre avós e netos se estabelece um diálogo no qual a memória atua tanto como a motivação de cada cinegrafista quanto como evocação para as idosas com suas receitas. Contextos históricos, tramas sociais, relações com o tempo e com o próprio corpo formatam as lembranças narradas pelas avós, constituindo, assim, uma janela aberta para o passado que é ressignificado no presente. A cozinha, lugar de realização do vídeo, é também um lugar de memória, afeto e vida.
Assessing sub-grid variability within satellite pixels over urban regions using airborne mapping spectrometer measurements
Authors: Tang Wenfu , Edwards David P. , Emmons Louisa K. , Worden Helen M. , Judd Laura M. , Lamsal Lok N. , Al-Saadi Jassim A. , Janz Scott J. , Crawford James H. , Deeter Merritt N. , Pfister Gabriele , Buchholz Rebecca R. , Gaubert Benjamin , Nowlan Caroline R.
Published: June 2021

Abstract. Sub-grid variability (SGV) in atmospheric trace gases within satellite
pixels is a key issue in satellite design and interpretation and validation
of retrieval products. However, characterizing this variability is
challenging due to the lack of independent high-resolution measurements.
Here we use tropospheric NO2 vertical column (VC) measurements from the Geostationary Trace gas and Aerosol Sensor Optimization (GeoTASO) airborne instrument with a spatial resolution of about 250 m×250 m to quantify the normalized SGV (i.e., the standard deviation of the sub-grid GeoTASO values within the sampled satellite pixel divided by the mean of the sub-grid GeoTASO values within the same satellite pixel) for different hypothetical satellite pixel sizes over urban regions. We use the GeoTASO measurements over the Seoul Metropolitan Area (SMA) and Busan region of South Korea during the 2016 KORUS-AQ field campaign and over the Los Angeles Basin, USA, during the 2017 Student
Airborne Research Program (SARP) field campaign. We find that the normalized SGV of NO2 VC increases with increasing satellite pixel sizes (from ∼10 % for 0.5 km×0.5 km pixel size to ∼35 % for 25 km×25 km pixel size), and this relationship holds for the three study regions, which are also within the domains of upcoming geostationary satellite air quality missions. We also quantify the temporal variability in the retrieved NO2 VC within the same hypothetical satellite pixels (represented by the difference of retrieved values at two or more different times in a day). For a given satellite pixel size, the temporal variability within the same satellite pixels increases with the sampling time difference over the SMA. For a given small (e.g., ≤4 h) sampling time difference within the same satellite pixels, the temporal variability in the retrieved NO2 VC increases with the increasing spatial resolution over the SMA, Busan region, and the Los Angeles Basin. The results of this study have implications for future satellite design and
retrieval interpretation and validation when comparing pixel data with
local observations. In addition, the analyses presented in this study are
equally applicable in model evaluation when comparing model grid values to
local observations. Results from the Weather Research and Forecasting model
coupled with Chemistry (WRF-Chem) model indicate that the normalized
satellite SGV of tropospheric NO2 VC calculated in this study could
serve as an upper bound to the satellite SGV of other species (e.g., CO and SO2) that share common source(s) with NO2 but have relatively longer lifetime.
Cycling and retention of nitrogen in European beech (Fagus sylvatica L.) ecosystems under elevated fructification frequency
Authors: Brumme Rainer , Ahrends Bernd , Block Joachim , Schulz Christoph , Meesenburg Henning , Klinck Uwe , Wagner Markus , Khanna Partap K.
Published: June 2021

Abstract. Atmospheric deposition of nitrogen (N) has exceeded its
demand for plant increment in forest ecosystems in Germany. High N inputs
increased plant growth, the internal N cycling within the ecosystem, the
retention of N in soil and plant compartments, and the N output by seepage
water. But the processes involved are not fully understood, notably the
effect of fructification in European beech (Fagus sylvatica L.) on N fluxes. The frequency
of fructification has increased together with air temperature and N
deposition, but its impact on N fluxes and the sequestration of carbon (C) and N in
soils have been hardly studied. A field experiment using 15N-labeled leaf
litter exchange was carried out over a 5.5-year period at seven long-term
European beech (Fagus sylvatica L.) monitoring sites to study the impact of current mast
frequency on N cycling. Mean annual leaf litterfall contained 35 kg N ha−1, but about one-half of that was recovered in the soil 5.5 years
after the establishment of the leaf litter 15N exchange experiment. In
these forests, fructification occurred commonly at intervals of 5 to 10 years, which has now changed to every 2 years as observed during this
study period. Seed cupules contributed 51 % to the additional litterfall
in mast years, which creates a high nutrient demand during their decomposition
due to the very high ratios of C to N and C to phosphorus (P).
Retention of leaf litter 15N in the soil was more closely related to
the production of total litterfall than to the leaf litterfall, indicating
the role of seed cupules in the amount of leaf N retained in the soil.
Higher mast frequency increased the mass of mean annual litterfall by about
0.5 Mg ha−1 and of litterfall N by 8.7 kg ha−1. Mean net primary
production (NPP) increased by about 4 %. Mean total N retention in soils
calculated by input and output fluxes was unrelated to total litterfall,
indicating that mast events were not the primary factor controlling total N
retention in soils. Despite reduced N deposition since the 1990s, about 5.7 out of 20.7 kg N ha−1 deposited annually between 1994
and 2008 was retained in soils, notably at acid sites with high N/P and C/P
ratios in the organic layers and mineral soils, indicating P limitation for
litter decomposition. Trees retained twice as much N compared to soils by
biomass increment, particularly in less acidic stands where the mineral soils
had low C/N ratios. These results have major implications for our
understanding of the C and N cycling and N retention in forest ecosystems.
In particular the role of mast products in N retention needs more research in
the future.
Hydrogen and carbon isotope fractionation factors of aerobic methane oxidation in deep-sea water
Authors: Kawagucci Shinsuke , Matsui Yohei , Makabe Akiko , Fukuba Tatsuhiro , Onishi Yuji , Nunoura Takuro , Yokokawa Taichi
Published: June 2021

Abstract. Isotope fractionation factors associated with various biogeochemical processes are important in ensuring the practicality of isotope tracers in biogeosciences at large. Methane is a key component of the subsurface biosphere and a notable greenhouse gas, making the accurate evaluation of methane cycles, including microbial methanotrophy, imperative. Although the isotope fractionation factors associated with methanotrophy been examined under various conditions, the dual-isotope fractionation factors of aerobic methanotrophy in oxic seawater column remain unclear. Here, we investigated hydrogen and carbon isotope ratios of methane as well as the relevant biogeochemical parameters and microbial community compositions in hydrothermal plumes in the Okinawa Trough. Methanotrophs were found to be abundant in plumes above the Hatoma Knoll vent site, and we succeeded in simultaneously determining hydrogen and carbon isotope fractionation factors associated with aerobic oxidation of methane (εH = 49.4 ± 5.0 ‰, εC = 5.2 ± 0.4 ‰) – the former being the first of its kind ever reported. This εH value is comparable with reported values from terrestrial ecosystems but clearly lower than those from aerobic and anaerobic methanotroph enrichment cultures, as well as incubations of methanotrophic isolates. The covariation factor between δ13CCH4 and δDCH4, Λ (9.4/8.8 determined using two different methods), was consistent with those from methanotrophic isolate incubations. These values determined herein are valuable for understanding dynamics of methane cycling in the marine realm, and future applications of the approach used herein to other habitats with methanotrophic activity will help reveal whether the small εH value observed herein is a ubiquitous feature across all marine systems.
A revised mid-Pliocene composite section centered on the M2 glacial event for ODP Site 846
Authors: Herbert Timothy D. , Caballero-Gill Rocio , Novak Joseph B.
Published: June 2021

Abstract. The composite section from ODP Site 846 has provided key data sets for
Pliocene stable isotope and paleoclimatic time series. We document here
apparent outliers in previously published data sets for stable isotopes and
alkenone-derived sea surface temperature (SST) estimates in the Pliocene interval containing the M2 glaciation (ca. 3.290–3.3 Ma) by tying
high-resolution core measurements to a continuous downhole conductivity log.
We generate a revised sequence of new stable isotopic and alkenone
measurements across the M2 event that correlate well to the revised splices
of color reflectance and gamma ray attenuation porosity evaluator data from
Site 846, and to a new composite section produced at equatorial Pacific ODP
Site 850. A new composite splice for Site 846 is proposed, along with
composite isotope and alkenone time series that should be integrated into
revised Pliocene paleoclimatic stacks.
Short communication: Runout of rock avalanches limited by basal friction but controlled by fragmentation
Authors: Haug Øystein T. , Rosenau Matthias , Rudolf Michael , Leever Karen , Oncken Onno
Published: June 2021

Abstract. Rock avalanches produce exceptionally long run-outs that correlate with their rock volume. This relationship has been attributed to the size-dependent dynamic lowering of the effective basal friction. However, it has also been observed that run-outs of rock avalanches with similar volumes can span several orders of magnitude, suggesting additional controlling factors. Here, we analyse analogue models of rock avalanches, with the experiments designed to test the role of dynamic fragmentation. We show that for a fixed low basal friction, the run-out of experimental rock avalanches varies over 2 orders of magnitude and is determined by their degree of fragmentation, while the basal friction acts only as an upper limit on run-out. We interpret the run-out's dependence on fragmentation as being controlled by the competition between mobility enhancing spreading and energy-consuming fragmentation limited by basal friction. We formalize this competition into a scaling law based on energy conservation, which shows that the variation in the degree of fragmentation can contribute to the large variation in run-out of rock avalanches seen in nature.
Quantifying the impact of land cover changes on hydrological responses in India
Authors: Naha Shaini , Rico-Ramirez Miguel A. , Rosolem Rafael
Published: June 2021

Abstract. The objective of this study is to assess the impacts of Land Use Land Cover change on the hydrological responses of the Mahanadi river basin, a large river basin in India. Commonly, such assessments are accomplished by using distributed hydrological models in conjunction with different land use scenarios. However, these models through their complex interactions among the model parameters to generate hydrological processes, can introduce significant uncertainties to the hydrological projections. Therefore, we seek to further understand the uncertainties associated with model parameterization in those simulated hydrological responses due to different land cover scenarios. We performed a sensitivity-guided model calibration of a physically semi-distributed model, the Variable Infiltration Capacity (VIC) within a Monte Carlo Framework to generate behavioural models for subcatchments of the Mahanadi river basin. These behavioural models are then used in conjunction with historical and future land cover scenarios from the recently released, Land use Harmonisation (LUH2) to generate hydrological predictions and related uncertainties from behavioural model parameterisation. The LUH2 dataset indicates a noticeable increase in the cropland (23.3 % cover) at the expense of forest (22.65 % cover) by the end of year 2100 compared to the baseline year, 2005. As a response, simulation results indicate a median percent increase in the extreme flows (defined as the 95th percentile or higher river flow magnitude) and mean annual flows in the range of 1.8 to 11.3 % across the subcatchments. The direct conversion of forested areas to agriculture (on the order of 30,000 km2) reduces the Leaf Area Index and which subsequently reduces the Evapotranspiration (ET) and increases surface runoff. Further, the range of behavioural hydrological predictions indicated variation in the magnitudes of extreme flows simulated for the different land cover scenarios, for instance uncertainty in far future scenario ranges from 17 to 210 cumecs across subcatchments. This study indicates that the recurrent flood events occurring in the Mahanadi river basin might be influenced by the changes in LULC at the catchment scale and suggests that model parameterisation represents an uncertainty, which should be accounted for in the land-use change impact assessment.
River runoff in Switzerland in a changing climate – changes in moderate extremes and their seasonality
Authors: Muelchi Regula , Rössler Ole , Schwanbeck Jan , Weingartner Rolf , Martius Olivia
Published: June 2021

Abstract. Future changes in river runoff will impact many sectors such as agriculture, energy production, or ecosystems. Here, we study changes in the seasonality, frequency, and magnitude of moderate low and high flows and their time of emergence. The time of emergence indicates the timing of
significant changes in the flow magnitudes. Daily runoff is simulated for 93 Swiss catchments for the period 1981–2099 under Representative Concentration Pathway 8.5 with 20 climate model chains from the most recent
transient Swiss Climate Change Scenarios. In the present climate, annual low flows typically occur in the summer
half-year in lower-lying catchments (<1500 m a.s.l.) and in the winter half-year in Alpine catchments (>1500 m a.s.l.). By the end of the 21st century, annual low flows are projected to occur in late summer and early autumn in most catchments. This indicates that decreasing precipitation and increasing evapotranspiration in summer and autumn exceed the water contributions from other processes such as snowmelt and glacier melt. In lower-lying catchments, the frequency of annual low flows increases, but their magnitude decreases and becomes more severe. In Alpine catchments, annual low flows occur less often and their magnitude increases. The magnitude of seasonal low flows is projected to decrease in the summer half-year in most catchments and to increase in the winter half-year in
Alpine catchments. Early time of emergence is found for annual low flows in
Alpine catchments in the 21st century due to early changes in low flows
in the winter half-year. In lower-lying catchments, significant changes in
low flows emerge later in the century. Annual high flows occur today in lower-lying catchments in the winter
half-year and in Alpine catchments in the summer half-year. Climate change
will change this seasonality mainly in Alpine catchments with a shift
towards earlier seasonality in summer due to the reduced contribution of
snowmelt and glacier melt in summer. Annual high flows tend to occur more
frequent, and their magnitude increases in most catchments except some
Alpine catchments. The magnitude of seasonal high flows in most catchments
is projected to increase in the winter half-year and to decrease in the
summer half-year. However, the climate model agreement on the sign of change in moderate high flows is weak.
Refined estimates of water transport through the Åland Sea, Baltic Sea
Authors: Westerlund Antti , Miettunen Elina , Tuomi Laura , Alenius Pekka
Published: June 2021

Abstract. Water exchange through the Åland Sea, Baltic Sea, greatly affects the environmental conditions in the neighbouring Gulf of Bothnia. Recently observed changes in the eutrophication status of the Gulf of Bothnia may be connected to changing nutrient fluxes through the Åland Sea. Pathways and variability of sub-halocline northward-bound flows towards the Bothnian Sea are important for these studies. While the general nature of the water exchange is known, that knowledge is based on only a few studies that are somewhat limited in details. Notably, no high-resolution modelling studies of water exchange in the Åland Sea area have been published. In this study, we present a configuration of the NEMO 3D hydrodynamic model for the Åland Sea-Archipelago Sea area at around 500 m horizontal resolution. We then use it to study the water exchange in the Åland Sea. We first ran the model for the years 2013–2017 and validated the results, with a focus on the simulated current fields. We found that the model reproduced current direction distributions and layered structure of currents in the water column with reasonably good accuracy. Next, we used the model to calculate volume transports across several transects in the Åland Sea. These calculations provided new detail of water transport in the area. Time series of monthly mean volume transports showed a consistent northward transport in the deep layer. In the surface layer there was more variability: while net transport was towards the south, in several years some months in late summer or early autumn showed net transport to the north. Furthermore, based on our model calculations, it seems that dynamics in the Lågskär Deep are more complex than has been previously understood. While Lågskär Deep is the primary route of deep water exchange, still a significant volume of deep water enters the Åland Sea through the depression west of the Lågskär Deep. Better spatial and temporal coverage of current measurements is needed to further refine the understanding of water exchange in the area.
Correction to: Bican, R., Christensen, C., Fallieras, K., Sagester, G., O’Rourke, S., Byars, M., & Tanner, K. (2021). Rapid Implementation of Telerehabilitation for Pediatric Patients During COVID-19
Authors: Cohn Ellen R.
Published: June 2021

Correction to: Bican, R., Christensen, C., Fallieras, K., Sagester, G., O’Rourke, S., Byars, M., & Tanner, K. (2021). Rapid Implementation of Telerehabilitation for Pediatric Patients During COVID-19. International Journal of Telerehabilitation, 13(1). https://doi.org/10.5195/ijt.2021.6371
The affiliation for each author was incorrectly stated as: Physical Medicine & Rehabilitation, Children’s Minnesota, Minneapolis, Minnesota, USA
The correct affiliation for each author is: Clinical Therapies, Nationwide Children’s Hospital, Columbus, Ohio, USA
The metadata for the original article has been corrected.
APPROACHES TO THE DEVELOPMENT OF ENGINEERING MODELS OF RADIOCARBON MIGRATION IN WATER BODIES
Authors:   Nuclear Safety Institute, Russian Academy of Sciences, Krylov A. L. , Nosov A. V. ,   Nuclear Safety Institute, Russian Academy of Sciences, Aron D. V. ,   Nuclear Safety Institute, Russian Academy of Sciences
Published: June 2021

The issues of radiocarbon forecasting in surface land water are considered. Numerical estimates of radiocarbon specific activity values in surface water caused by natural sources, anthropogenic discharges, and emissions from NPPs are presented. The estimates are based on literature data on stable carbon and 14C measurements in air, water, and other components of water bodies. The estimates of the main parameters of biochemical migration of 14C in surface water are given. A need in taking into account the elimination biochemical cycle of 14C for modeling its migration is substantiated.
QUASI-BIENNIAL OSCILLATION OF ZONAL WIND IN THE EQUATORIAL STRATOSPHERE AND ITS INFLUENCE ON INTERANNUAL FLUCTUATIONS IN THE DEPTH OF THE ANTARCTIC OZONE HOLE
Authors:   Arctic and Antarctic Research Institute, Gabis I. P.
Published: June 2021

The Antarctic ozone hole is observed annually in spring due to the complex influence of photochemical and dynamical processes. The increased concentration of ozone-depleting substances in the atmosphere causes a long-term negative trend in total ozone (TO). Intense interannual fluctuations in TO against a background of the long-term trend associated with dynamic atmospheric processes do not allow assessing definitely the direction of the trend (growth/decline) in the recent years. Studying the dependence of interannual fluctuations in the ozone hole intensity on the equatorial quasi-biennial oscillation (QBO) allows identifying natural causes of variations and assessing the trend due to anthropogenic factors. The long-term QBO forecast allows predicting different phenomena that depend on the QBO.