bluuebunny/crossref_metadata_2025 huggingface dataset:
Scoping Review about parent education program according to parent self-concept
Authors:   The Korea Associantion For Early Childhood Education Administration, Ko Kwang-Sook , Kim Seong-Gil
Published: April 2023

This study reviewed the subject scope literature for research records on the correlation between parental education programs and parental self-concept, and I hereby intend to apply this study as empirical basic data for the development and field application of future self-concept improvement parent education programs. To this end, among domestic academic and degree papers from 1997 to October 2022, I selected the final 40 articles through the standardized six-step process presented in the Scoping Review method. The results of analyzing the contents through frequency and percentage are as follows. First, 82.5 percent of mother participants, 32.5 percent of 21 to 30 subjects, 37.5 percent of child age infant, 92.5 percent of quantitative research methods, 52.5 percent of degree papers, 50.0 percent of Rosenberg (1965) self-esteem tests, 22.5 percent of parent education, and 35.0 percent of eighth sessions. Second, among the 17 types of parent education program conducted, group counseling parent education (17.5%) and TA (15%) were the most conducted, and those were meaningful for improving parent self-concept. However, just because this is a statistically meaningless program(APN, reality therapy, reading education) does not mean that it is generally meaningless to improve self-concept. Additionally, this suggests the needs for program development and institutional support for fathers' participation, and is meaningful in presenting the direction of the parent education program to improve self-concept improvement.
The influence of weed infestation and pea (Pisum sativum (Linn.)) cropping system on the beneficial and harmful entomofauna
Authors:   Institute of Agriculture - Karnobat, Agricultural Academy - Sofia, Maneva Vasilina , Atanasova Dina ,   Institute of Agriculture - Karnobat, Agricultural Academy - Sofia, Bozhanova Violeta ,   Institute of Fields Crops - Chirpan, Agricultural Academy - Sofia
Published: April 2023

The experiment was carried out in the conventional and organic experimental fields of the Institute of Agriculture - Karnobat, in the period 2019 - 2022. The aim of the experiment was to study the influence of weed infestation and cropping system of pea (Pisum sativum (Linn.)) on the beneficial and harmful entomofauna. Six and seven species of insects from seven families and three orders were found to damage pea in organic and conventional farming, respectively. Their density was higher in conventional farming. The most economically important and the most widespread pest in both types of cropping was the aphid Acyrthosiphon pisum (Harris, 1776). Of the beneficial insects, thirteen species were found in pea in organic and eleven in conventional farming, from eight families and five orders. Greater species diversity and higher numbers were observed in organically grown pea during all four years of the study. The absence of herbicide treatment in organic farming and the presence of more blooming vegetation stimulate the multiplication of beneficial entomofauna, regulating the population density of the aphids in pea. The correlations between the blooming vegetation and the beneficial entomofauna and between the beneficial and harmful entomofauna have been demonstrated.
Otorhinolaryngological symptoms in hospitalized patients with COVID-19 - single-medical-center study in Serbia
Authors: Sankovic-Babic Snezana , Milutinovic Vladan , Radin Zorana , Sapic Neda , Colic Sanja
Published: April 2023

Introduction/Objective. The infectious condition named coronavirus disease 2019 (COVID-19) was caused by coronavirus2 (SARS-Cov-2). Patients with COVID-19 disease may have symptoms which can range from mild to severe clinical condition. The aim of this study was to observe and analyze the presence of otorhinolaryngology symptoms in hospitalized patients with moderate to severe COVID-19 disease. Methods. The descriptive clinical study analyzed data from medical records in 230 hospitalized patients with moderate to severe COVID-19 pneumonia at Zvezdara Clinical Hospital Center, Belgrade, Serbia. Otorhinolaryngology symptoms as well as generalized COVID-19 related symptoms were analyzed from medical records during the year 2021. SARS-CoV-2 virus infection was previously confirmed in all patients with positive polymerase chain reaction test and/or rapid antigen test. Results. The mean age of 230 patients included in this study was 64 years. The most common general symptoms were cough 72%, fever 52%, dyspnea 46%, malaise 46% while to a lesser extent were observed myalgia 19%, vomitus 3%, and diarrhea 3%. The distribution of otorhinolaryngological symptoms showed that the most frequent symptom was anosmia 22%, while the throat pain was present in 20% and ageusia in 19% of patients. The otorhinolaryngological symptoms which were present in lower frequencies were headache in 16% of patients, tinnitus in 6%, vertigo in 5%, and hearing loss in 3% of patients. Comorbidities were observed more often in patients older than 50 years. Hypertension was the most common chronic disease in 60%, followed by diabetes in 23%, chronic obstructive pulmonary disease in 7%, malignancy in 7%, hypothyroidism in 6%, and renal disease in 4% of patients. Conclusion. Otorhinolaryngological conditions that should be the subject of further post COVID survey are prolonged anosmia, ageusia or hypogeusia, auditory dysfunction and vertiginous complaints.
Allergic Contact Dermatitis from Luliconazole: Implication of the Dithioacetal Structure
Authors: Tanaka Tomoko , Satoh Takahiro , Yokozeki Hiroo
Published: April 2023

This article does not have an abstract.
High Prevalence of Oncogenic Human Papilloma Virus in Women Not Attending Organized Cytological Screening
Authors: Stenvall Harriet , Wikström Ingrid , Wilander Erik
Published: April 2023

Since the introduction of organized cytological screening in Sweden, most women currently presenting with cervical cancer are those who have not attended the programme and who have no cytological screening history. The aims of this study were: (i) to measure the response rate among women not attending organized cytological screening who were offered a device for self-sampling a vaginal smear at home; (ii) to examine the prevalence of high-risk human papilloma virus (HPV) among women performing self-sampling. Women aged 35–50 years, who had not participated in organized cytological screening for more than 6 years, were offered the opportunity to collect vaginal samples at home using a self-sampling device (Qvintip?). The material collected was analysed for high-risk HPV using the Hybrid Capture 2 method. Of 369 women included in the study, 179 (49%) ordered the self-sampling device and 117 (32%) performed self-sampling at home and sent the sample to our laboratory for analysis. The mean prevalence of high-risk HPV was 26% (30/117), 31% (25/80) in women aged 35–42 years and 14% (5/37) in women aged 43–50 years. There was no significant difference in the participation rate with regard to age. The prevalence of high-risk HPV in women not covered by organized screening was considerably higher than in the general population; therefore they may represent a category at high risk of cervical cancer. The study shows that the use of a disposable self-sampling device for HPV testing is a relevant method to increase the participation rate in countries with organized cytological screening.
Clinical and Microbiological Comparisons of Isotretinoin vs. Tetracycline in Acne Vulgaris
Authors: Oprica Cristina , Emtestam Lennart , Hagströmer Lena , Erik Nord Carl
Published: April 2023

The aim of this study was to compare the clinical and microbiological effect on Propionibacterium acnes of oral tetracycline plus topical adapalene vs. oral isotretinoin in moderate to severe acne vulgaris. Male and female acne patients with moderate or severe inflammatory disease were enrolled and assigned randomly to 6 months of treatment with oral tetracycline hydrochloride plus topical adapalene, or oral isotretinoin, in a controlled, open study. After cessation of oral treatment the antibiotic-treated group received topical adapalene for the 2-month follow- up period. Clinical and microbiological assessments were performed. Skin samples for microbial identification and quantification were taken at baseline, after 2, 4 and 6 months of treatment, and 2 months after cessation of treatment. Patients treated with isotretinoin showed prolonged significant remission compared with the other group. The density of resistant propionibacteria did not change significantly in any of the groups and there was no correlation between resistant P. acnes and the clinical response in any of the regions investigated. Antibiotic treatment was found to be a good alternative to isotretinoin, regardless of the presence of antibiotic-resistant P. acnes, although isotretinoin had a better effect, with prolonged remission after treatment.
Expression of Allograft Inflammatory Factor-1 in Inflammatory Skin Disorders
Authors: Orsmark Christina , Skoog Tiina , Jeskanen L. , Kere Juha , Saarialho-Kere Ulpu
Published: April 2023

Allograft inflammatory factor-1 (AIF-1) is an evolutionarily conserved, inflammatory protein produced by activated macrophages during chronic transplant rejection and in inflammatory brain lesions. Since T-cell-mediated inflammation is common to various dermatoses and nothing is known about AIF-1 in skin, we studied its protein expression at the tissue level and regulation in monocytic cell lines by various agents. Using immunohistochemistry, we found that AIF-1 is expressed at low levels in normal skin, but is highly upregulated in various inflammatory skin disorders, such as psoriasis, lichen planus, graft-versus-host disease and mycosis fungoides. The main cell types expressing AIF-1 in affected skin are macrophages and Langerhans` cells. We also show by real-time PCR that AIF-1 mRNA levels in monocytic THP-1 and U937 cell lines are significantly upregulated by retinoic acid as well as a number of cytokines. We conclude that AIF-1 may mediate survival and pro-inflammatory properties of macrophages in skin diseases.
Human Papilloma Virus in Skin, Mouth and Uterine Cervix in Female Renal Transplant Recipients With or Without a History of Cutaneous Squamous Cell Carcinoma
Authors: Nordin Peter , Göran Hansson Bengt , Hansson Carita , Blohmè Ingemar , Larkö Olle , Andersson Kristin
Published: April 2023

Some human papillomaviruses are thought to be associated with skin cancer. In this pilot study, 21 female renal transplant carriers, 10 with a history of skin squamous cell carcinoma and 11 without, together with 9 age-matched healthy women were investigated for human papillomavirus DNA in sun-exposed (forehead) and less sun-exposed (buttock) skin, mouth and uterine cervix. Paraffin-embedded tumours from 9 of the patients with a history of squamous cell carcinoma were analysed. Healthy skin from both the healthy and the immunosuppressed individuals harboured a wide variety of papillomaviruses. In the healthy individuals, samples from less sun-exposed skin showed a lower prevalence of human papillomavirus DNA than corresponding samples from the immunosuppressed patients (4/9 and 7/9, respectively). Among the immunosuppressed patients, human papillomavirus DNA was found as frequently in buttock samples (17/21) as in forehead samples (17/20). There was no increased prevalence of human papillomavirus in the cervix or mouth samples from the immunosuppressed patients.
Efalizumab-induced Lupus-like Syndrome
Authors: Durox Hélene , Sparsa Agnès , Loustaud-Ratti Véronique , Prey Sorilla , Gondran Guillaume , Manea Petrus , Vidal Elisabeth , Bedane Christophe
Published: April 2023

This article does not have an abstract.
Unusual Presentation of Orf in an Otherwise Healthy Individual
Authors: Villadsen Louise S. , Zachariae Claus O.C.
Published: April 2023

This article does not have an abstract.
Precursor B-cell Lymphoblastic Lymphoma Presenting as Solitary Infiltrative Plaque in a Child
Authors: Eun Choi Jae , Hyun Ahn Hyo , Chul Kye Young , Nam Kim Soo
Published: April 2023

This article does not have an abstract.
Successful Treatment of Kimura's Disease with a 595-nm Ultra-Long Pulsed Dye Laser
Authors: Eun Choi Jae , Hong Seo Soo , Hwan Kim Il , Chul Kye Young , Wook Son Sang
Published: April 2023

This article does not have an abstract.
Itch Intensity Evaluated in the German Atopic Dermatitis Intervention Study (GADIS): Correlations with Quality of Life, Coping Behaviour and SCORAD Severity in 823 Children
Authors: Weisshaar Elke , Diepgen Thomas L. , Bruckner Thomas , Fartasch Manigé , Kupfer Jörg , Lob-Corzilius Thomas , Ring Johannes , Scheewe Sibylle , Scheidt Reginald , Schmid-Ott Gerhardt , Schnopp Christina , Staab Doris , Szcepanski Rüdiger , Werfel Thomas , Wittenmeier Marita , Wahn Ulrich , Gieler Uwe
Published: April 2023

The German Atopic Dermatitis Intervention Study (GADIS), which includes 823 children and adolescents, showed that age-related educational programmes are effective in the long-term management of atopic dermatitis. We investigated whether the itch severity obtained in the scoring of atopic dermatitis (SCORAD) correlates with quality of life and coping behaviour in children and parents. There were significant but low correlations between the severity of atopic dermatitis and the itch intensity. Itch and sleeplessness were significantly correlated. Significant correlations of itch with the coping behaviour and quality of life in parents of children with atopic dermatitis were measured. The coping and itching behaviour of children (8-12 years) and adolescents (13-18 years) had higher significant correlations with the itch compared with the parents' answers. Quality of life in children (8-12 years) and adolescents (13-18 years) showed a significant negative correlation with itch intensity. Quality of life, itch intensity and coping strategies should be considered when treating patients with atopic dermatitis.
Psoriasis Vulgaris Associated with Acne Vulgaris: Differential Effects of Biologicals?
Authors: Colsman Andreas , Sticherling Michael
Published: April 2023

This article does not have an abstract.
Successful Treatment of an Elderly Patient with Refractory Ultraviolet-A-sensitive Atopic Eczema with Mycophenolic Acid
Authors: Bär Michael , Schmitt Jochen , Bauer Andrea , Wozel Gottfried , Meurer Michael
Published: April 2023

This article does not have an abstract.
Chronic Graft-versus-host Disease and Non-melanoma Skin Cancer in Children: Report of Two Cases
Authors: Borroni Riccardo G. , Vassallo Camilla , Ciocca Olga , Castello Michela , Brazzelli Valeria , Zecca Marco , Locatelli Franco , Borroni Giovanni
Published: April 2023

This article does not have an abstract
Targeted Broadband Ultraviolet B Phototherapy Produces Similar Responses to Targeted Narrowband Ultraviolet B Phototherapy for Vitiligo: A Randomized, Double-blind Study
Authors: Asawanonda Pravit , Kijluakiat Jirasin , Korkij Wiwat , Sindhupak Wannasri
Published: April 2023

Narrowband ultraviolet B (NB-UVB) phototherapy, with a 308-nm xenon chloride excimer laser, and targeted UVB phototherapy have produced encouraging therapeutic results for vitiligo. However, very few studies employing broadband UVB exist. Moreover, there has been no direct comparison study between broadband UVB and NB-UVB for the treatment of vitiligo. The aims of this study were to compare the repigmenting efficacy of targeted broadband UVB phototherapy with that of NB-UVB in an equi-erythemogenic manner. Twenty identical vitiliginous lesions from 10 patients were randomly allocated to receive either targeted broadband UVB or targeted NB-UVB phototherapy. UV fluences were started at 50% of the minimal erythema dose detected within the vitiliginous patches, then increased gradually, in the same manner, to ensure equi-erythemogenic comparison. Treatments were carried out twice weekly for 12 weeks. The results show that grade 1, i.e. 1-25% repigmentation, to grade 2, 26-50% repigmentation, occurred in 6 of 10 subjects. Responses in terms of repigmentation, de-pigmentation, or lack thereof, were similar between lesions receiving broadband and NB-UVB phototherapy. Onset of repigmentation occurred as early as 4 weeks of treatment in most subjects. Treatments were well tolerated, with only minimal erythema and hyperpigmentation.
Microscopic Distribution of Protoporphyrin (PpIX) Fluorescence in Superficial Basal Cell Carcinoma During Light-fractionated Aminolaevulinic Acid Photodynamic Therapy
Authors: De Haas Ellen R.M. , De Bruijn Henriette S. , Sterenborg Henricus J.C.M. , Neumann A. Martino H.: Robinson
Published: April 2023

Light fractionation in aminolaevulinic acid photodynamic therapy (PDT) of superficial basal cell carcinoma has been shown to enhance the therapeutic efficacy significantly. We have shown previously that this increase in efficacy is not simply due to an increase in the amount of protoporphyrin utilized during therapy. The present study investigated the spatial distribution of protoporphyrin in 32 superficial basal cell carcinomas undergoing light-fractionated PDT. Superficial fluorescence imaging performed during therapy was compared with the microscopic analysis of protoporphyrin fluorescence in biopsies acquired immediately before the second of two light fractions. The microscopic distribution of fluorescence was also compared with tumour sections immunohistochemically stained for Ki-67. Large variations in superficial and microscopic protoporphyrin fluorescence were found in both control and treated lesions. Despite these variations there was a reasonable correlation between the two techniques (R2=0.86). The mean fluorescence intensity in control biopsies was greater than in illuminated lesions before the second light fraction, but there was no significant difference in the variation within and between regions of interest in each of these sets of lesions. There was no clear trend in depth of protoporphyrin reappearance during the dark interval between light fractions. The general distribution of cells stained positive for Ki-67 followed the protoporphyrin fluorescence that was associated with islands of basal cell carcinoma. In conclusion, this study confirms that the mean relative re-synthesis of protoporphyrin after PDT is consistent with that found previously in pre-clinical models. There are large variations in fluorescence within superficial basal cell carcinoma that include regions of tumour cells that do not synthesize protoporphyrin.
Prevention of Polymorphic Light Eruption with a Sunscreen of Very High Protection Level Against UVB and UVA Radiation Under Standardized Photodiagnostic Conditions
Authors: Schleye Verena , Weber Oliver , Yazdi Amir , Benedix Frauke , Dietz Klaus , Röcken Martin , Berneburg Mark
Published: April 2023

Polymorphic light eruption (PLE), with an overall prevalence of 10-20%, is mainly provoked by ultraviolet A (UVA) (320-400 nm) and to a lesser degree by UVB (280-320 nm). The most effective prophylaxis of PLE, application of UV protection clothing, is not feasible for all sun-exposed areas of the skin and UV-hardening is time-consuming and may be associated with side-effects. Most sunscreens protect predominantly against UVB and therefore fail to prevent PLE. The protection level of potent UVA-protective filters remains unresolved. This single-centre, open, placebo-controlled, intra-individual, comparative study, analysed the efficacy of a sunscreen of very high protection level against UVB and UVA, containing methylene bis-benzotriazolyl tetramethylbutylphenol (Tinosorb M), bis-ethylhexyloxyphenol methoxyphenyl triazine (Tinosorb S) and butyl methoxydibenzoylmethane as UVA absorbing filters, in the prevention of PLE under standardized photodiagnostic conditions. After determination of the minimal erythema dose at day 0, photoprovocation was performed in 12 patients with a clinical history of PLE, on days 1, 2 and 3 with 100 J/cm2 UVA and variable doses of UVB, starting with the 1.5-fold minimal erythema dose of UVB. Prior to irradiation, placebo was applied to the right and sunscreen to the left dorsal forearm under COLIPA (European Cosmetic, Toiletry and Perfumery Association) conditions. In 10 patients PLE could be provoked at the placebo site, with positive reactions in 90% of the UVA, 40% of the UVB and 90% of the UVA/UVB irradiated fields. At the site with the active treatment none of these patients developed PLE. These data demonstrate that a sunscreen with effective filters against UVA and UVB can successfully prevent the development of PLE. Further studies are needed to examine whether regular application of sunscreen under everyday conditions, especially in doses less than the tested COLIPA-norm, could be an equivalent alternative to UV-hardening therapy.
Rapidly Growing Cobblestone-like Nodules as a Manifestation of Myeloid Sarcoma
Authors: Nakagawa Satoshi , Tagami Hachiro , Ichinohasama Ryo , Aiba Setsuya
Published: April 2023

This article does not have an abstract
ILVEN: Is it Psoriasis? Debate Based on Successful Treatment with Etanercept
Authors: Renner Regina , Colsman Andreas , Sticherling Michael
Published: April 2023

This article does not have an abstract
T-cell Receptor Excision Circles (TREC) in CD4+ and CD8+ T-cell Subpopulations in Atopic Dermatitis and Psoriasis Show Major Differences in the Emission of Recent Thymic Emigrants
Authors: Just Helle L. , Deleuran Mette , Vestergaard Christian , Deleuran Bent , Thestrup-Pedersen Kristian
Published: April 2023

We used T-cell receptor excision circles (TREC) to evaluate thymic function in adult patients with atopic dermatitis and psoriasis. We observed that men, but not women, with atopic dermatitis had a significantly faster decline in TREC content with increasing age compared with healthy men. In contrast, both men and women with psoriasis had significantly reduced TREC levels, which were, on average, only 30% of that of healthy persons. In atopic dermatitis the levels of TREC declined with increasing levels of IgE, disease intensity and extent of eczema. Furthermore, patients with atopic dermatitis showed signs of altered thymus function, as they had a significantly greater variation in TREC content measured over time than healthy controls, especially within the CD8+ T-cell subpopulation. Because both atopic dermatitis and psoriasis patients have an increased number of T-cells, this indicates that atopic dermatitis patients can have compensatory emissions of thymic emigrants, whereas psoriatic patients do not, thus supporting different thymic function in these two diseases.
Vulvar Basal Cell Carcinoma with Clitoral Involvement
Authors: Celik Husnu , Gurates Bilgin , Yavuz Adem , Dogan Zeynep , Cobanoglu Bengu , Saral Yunus
Published: April 2023

This article does not have an abstract.
Psoriasiform Acral Dermatitis: Long-term Follow-up of 10 Cases
Authors: Patrizi Annalisa , Medri Matelda , Neri Iria
Published: April 2023

This article does not have an abstract.
Therapeutic Effectiveness of Various Treatments for Eosinophilic Pustular Folliculitis
Authors: Fukamachi Shoko , Kabashima Kenji , Sugita Kazunari , Kobayashi Miwa , Tokura Yoshiki
Published: April 2023

Eosinophilic pustular folliculitis is a rare dermatosis. Recently, in addition to oral indomethacin, other treatments have been applied for eosinophilic pustular folliculitis. The aim of this study was to assess the effectiveness of various therapies encompassing conventional to newly applied drugs for eosinophilic pustular folliculitis. Twenty patients with eosinophilic pustular folliculitis seen in our department were investigated. The effectiveness of each treatment was assessed by a severity score index. Eleven patients were treated with oral indomethacin, and the severity scores of all patients were decreased after the treatment. Oral cyclosporine was markedly effective in all 11 patients treated, and topical tacrolimus ointment alleviated eosinophilic pustular folliculitis in 3 of 7 with one patient showing a remarkable reduction in the severity score. In addition to indomethacin or other oral non-steroidal anti-inflammatory drugs, oral cyclosporine and topical tacrolimus may be beneficial choices when patients have been resistant to previous treatments.
Eosinophilic Pustular Folliculitis Occurring after Bone Marrow Transplantation in a Child with Aplastic Anaemia
Authors: Ogawa Eisaku , Okuyama Ryuhei , Niizuma Hidetaka , Tagami Hachiro , Tsuchiya Shigeru , Aiba Setsuya
Published: April 2023

This article does not have an abstract.
Myeloid Sarcoma Developing in Pre-existing Pyoderma Gangrenosum
Authors: Bruun Kristensen Ida , Møller Hanne , Wanscher Kjærskov Mette , Yderstræde Knud , Boe Møller Michael  , Olav Bergmann J.
Published: April 2023

We report here a case of pyoderma gangrenosum in a patient with myelodysplastic syndrome developing into myeloid sarcoma as a sign of transformation to acute leukaemia. The patient was treated successfully with intensive chemotherapy and achieved complete remission, and her otherwise expanding ulcers started to heal. This is the first reported case of secondary blastic infiltration in pyoderma gangrenosum, and it underlines the importance of performing re-biopsy of non-healing ulcers, especially in patients with an underlying haematological disease.
Erythrosis Pigmentosa Mediofacialis: Familial Occurrence
Authors: Bovenschen Jorn H. , Seyger Marieke M.B.
Published: April 2023

This article does not have an abstract.
Pyoderma Vegetans: A Case for Discussion
Authors: Adişen Esra , Tezel Fulya , Gürer Mehmet Ali
Published: April 2023

This article does not have an abstract.
Eccrine Poroma: A Clinical-Dermoscopic Study of Seven Cases
Authors: Ferrari Angela , Buccini Pierluigi , Silipo Vitaliano , De Simone Paola , Mariani Giustino , Marenda Samantha , Hagman Johanna H. , Amantea Ada , Panetta Chiara , Catricalà Caterina
Published: April 2023

Eccrine poroma can mimic benign and malignant melanocytic and non-melanocytic lesions. To date, little is known about the dermoscopic features of this condition. Seven histopathologically proven cases of eccrine poroma were examined using dermoscopy by three independent dermatologists. Both glomerular and hairpin vessels were observed in 71% of cases, whereas linear irregular vessels were observed in 43% of cases. A white-to-pink halo surrounding the vessels and multiple pink-white structureless areas were also frequently found (in 86% and 71% of cases, respectively). Three dermoscopic "profiles were identified all characterized by the presence of halo surrounding the vessels as well as by the association of two additional different features namely: glomerular vessels and pink-white structureless areas glomerular and linear irregular vessels hairpin vessels and linear irregular vessels. However due to the small number of lesions studied so far we suggest that these profiles should be considered as likely but not definitely pathognomonic signs of eccrine poroma.
Photodynamic Therapy Following Carbon Dioxide Laser Enhances Efficacy in the Treatment of Extramammary Paget's Disease
Authors: Fukui Toshimitsu , Watanabe Daisuke , Tamada Yasuhiko , Matsumoto Yoshinari
Published: April 2023

Surgical resection is the first-choice therapy for extramammary Paget's disease, but extensive resection is highly invasive and non-surgical treatments are sometimes preferred. Although photodynamic therapy (PDT) has been used for extramammary Paget's disease for some time, recurrence and residual tumour cells are common. In the present study, five patients with extramammary Paget's disease with a total of eight lesions first underwent carbon dioxide (CO2) laser abrasion, followed by 3 h of occlusive application of aminolaevulinic acid (ALA) and then 100 J/cm2 irradiation with a 630-nm excimer dye laser. This combination treatment regime was repeated every 2 weeks for a total of 3 times. Group 1 comprised two patients (five lesions) who received CO2 laser and ALA-PDT only. Group 2 comprised three patients (three lesions) who received CO2 laser and ALA-PDT for residual tumour cells following surgery. Follow-up examin ations showed that seven lesions in five patients had not recurred after 12 months, suggesting the efficacy of the present method.
Dengue- A Global Threat; Need to be Halted with Sound Scientific Measures to Stop its Rapid Devastation throughout the World
Authors: SH Syeda
Published: April 2023

Dengue virus belongs to family Flaviviridae and genus Flavivirus, transmitted primarly in a cycle through human beings and mosquito vector. The rate of incidence of dengue fever epidemics has reached to the highest, since past few years. Over a geologically expanding area, the level of hyperendemic transmission has been established. The person with sequential dengue infection is also victim of dengue hemorrhagic fever (DHF) which is the most severs disease. The rate of incidence of DHF and the possibility of sequential infections has increased intensely, first of all in Asian countries and currently in America. The wide spreading of mosquito Aedes aegypti is even more alarming. As a consequence of insufficiency of antiviral drugs and potential vaccine, a large number of individuals are infected with severe dengue virus every year which causes huge death cases. Conclusion: Effective vector control measures are the only weapon against dengue these days, however effective potential drugs and vaccine are expected in future.
CONCEPÇÕES DE PROFESSORES SOBRE O ENSINO DO TEMA QUEIMADAS NAS AULAS DE CIÊNCIAS EM ESCOLAS PÚBLICAS DE RONDONÓPOLIS/MT
Authors: Pompermayer Verdério Leonardo Álisson , Aoyama Barbosa Souza Leila Cristina
Published: April 2023

A prática de Queimadas é considerada comum para a limpeza de áreas/terrenos, visando principalmente à liberação de espaços para a agricultura e pecuária e para a queima de lixo doméstico. Considerando tal problemática, o objetivo deste estudo é caracterizar a abordagem do tema Queimadas nas aulas de ciências para o Ensino Fundamental II em escolas públicas de Rondonópolis/MT, a partir do trabalho desenvolvido por docentes. Para tanto, metodologicamente, foi realizada pesquisa de campo, por meio da aplicação de um questionário semiestruturado a dez professores da disciplina de Ciências do Ensino Fundamental II do município de Rondonópolis/MT. Os resultados obtidos apontaram que todos os professores participantes consideram importante a abordagem do tema Queimadas nas aulas de ciências e fazem o uso do livro didático para tal abordagem. Os professores também fazem uso de recursos audiovisuais, como vídeos e imagens.
AUDIO-VISUAL AIDS MEDIA, LANGUAGE ACQUISITION AND ATTITUDE: AN INITIAL INVESTIGATION IN THE EFL CLASSROOMS
Authors: Indrayanti Iin , Kuntoro Adi , Romadhon Syaefani Arif
Published: April 2023

Audio-Visual-Aids (AVA) media is a type of media that has long been acknowledged as a teaching aid in foreign language contexts. However, its uses are varied greatly from teacher to teacher depending on the content, inventiveness, classroom needs, and benefits approaches in language learning. Thus, the current research focused on the investigation of the analysis of vocabulary acquisition in the form of nouns and word spellings. In addition, the researcher also determined the influences of the use of the media on learners’ attitudes. A quantitative pre-experimental research approach in a one-group pre-test post-test design was performed involving 35 participants. AVA media was given within four meetings in the form of PowerPoint slides completed with original audio dubbing and fifteen images representing “Things in My Room”. To get further looks at their attitude, the participants also completed a questionnaire responding to 4 Likert Scales regarding their experiences. The analysis was reported to find out the average scores and initial hypotheses using a t-test on two main focuses with a 0.05 significance level. Findings showed a positive significant difference in the average scores of students’ vocabulary acquisition in the pre-test (7.66) and post-test (12.37) or 12.37 7.66. Scores of the tcoun reached higher than the ttable or 18,56438 2,021. Most of the students agreed and strongly agreed, that learning with AVA media brought some benefits to their learning experiences, particularly in the context of Vocabulary Acquisition.
Dynamic dependencies and return connectedness among stock, gold and Bitcoin markets: Evidence from South Asia and China
Authors: Zeng Hongjun , Lu Ran , Ahmed Abdullahi D.
Published: April 2023

Research background: In order to examine market uncertainty, the paper depicts broad patterns of risk and systematic exposure to global equity market shocks for the major South Asian and Chinese equity markets, as well as for specific assets (gold and Bitcoin).
Purpose of the article: The purpose of this paper is to investigate the dynamic correlation among the major South Asian equity markets (India and Pakistan), the Chinese equity markets, the MSCI developed markets, Bitcoin, and gold markets.
Methods: While applying the GARCH-Vine-Copula model and the TVP-VAR Connectedness approach, major patterns of dependency and interconnectedness between these markets are investigated.
Findings & value added: We find that risk shocks from developed equity markets are critical in these dynamic links. A net return spillover from Bitcoin to the Chinese and Pakistani stock markets throughout the sample period is reported. Interestingly, gold can be applied to hedge and diversify positions in China and major South Asian markets, particularly following the COVID-19 outbreak. Our paper presents three main original add valued: (1) This paper adds global factors to the targeted study of risk transmission among South Asian and Chinese stock markets for the first time. (2)The assets of Bitcoin and gold were added to the study of risk transmission among South Asian and Chinese stock markets for the first time, enabling the research in this paper to observe the non-linear link among the South Asian and Chinese stock markets with them. (3) Our research adds to these lines of inquiry by giving empirical evidence on how COVID-19 altered the dependent structure and return spillover dynamics of Bitcoin, gold and South Asian and Chinese stock markets for the first time. Our results have critical implications for investors and policymakers to effectively understand the nature of market forces and develop risk-averse strategies.
The approach to supply chain cooperation in the implementation of sustainable development initiatives and company's economic performance
Authors: Małys Łukasz
Published: April 2023

Research background: The idea of sustainable development, in the face of the challenges encountered by contemporary society, is gaining increasing popularity. Currently, it recognizes the substantial role that companies play in its successful implementation. Initiatives in the field of sustainable development may be undertaken by companies independently as part of their own activities, or together with entities forming the supply chain as an element of sustainable supply chain management.
Purpose of the article: Identification of groups of companies that are characterised by a different approach to cooperation in the field of sustainable development in the supply chain.
Methods: The quantitative research was conducted in September 2020 with the use of the CATI (Computer-Assisted Telephone Interview) technique and a standardised survey questionnaire. A total of 500 randomly selected companies located in Poland participated in this study. The respondents were representatives of top management of the companies. In order to identify various groups of companies, a cluster analysis was performed using the k-means method in SPSS.
Findings & value added: Based on the literature analysis, 3 areas of sustainable development have been identified, in which companies can become involved ? green design, sustainable operations, and reverse logistics & waste management. For each of the 3 areas, 3 clusters of companies were identified: companies that are not involved in sustainable development at all (1), companies that carry out most of the sustainable development initiatives independently (2), companies that carry out most of the sustainable development initiatives jointly with supply chain partners (3). The article also shows that the companies in different cluster differ in terms of perceived economic benefits achieved thanks to the implementation of sustainable development initiatives. This may suggest the need to develop separate sustainability solutions for such groups of companies in the future.
Variations of Nivometeorological Parameters During 2021-2022 Winter.
Authors:   Regional Meteorological Center Transilvania Sud, 49 Someșului Str, Sibiu, Romania, MILIAN Narcisa , RECKERTH  ,   Regional Meteorological Center Transilvania Sud, 49 Someșului Str, Sibiu, Romania
Published: April 2023

The paper presents and analyze snow and meteorological parameters of 2021-2022 winter, measured at the weather stations with nivological program (Predeal, Sinaia 1500, Parâng, Semenic, Vlădeasa, Ceahlău-Toaca, Iezer, Călimani, Țarcu, Bâlea-Lac, Vârful-Omu), as well as the estimated avalanche risk for each monitored massif.
Smart Electronic System for Monitoring Water Quality Parameters in Fish Tanks
Authors:   BEIA Consult International, R&D Department, Bucharest, Romania, DĂNILĂ Andrei-Bogdan , BĂLĂCEANU Cristina ,   BEIA Consult International, R&D Department, Bucharest, Romania, ORZA Oana ,   BEIA Consult International, R&D Department, Bucharest, Romania, BOSOC Sabina ,   BEIA Consult International, R&D Department, Bucharest, Romania
Published: April 2023

Fish farming represents a strong link in the value chain of food distribution over the world. There are different types of farms like RAS, continuously water alimented pounds, lake, maritime, etc. The self-cleaning water capability of a tank system is the key factor in describing RAS (recirculating aquaculture system) systems. This factor is crucial for the survival of farmed fish in urban aquaculture systems. The aim of this paper consists in describing the design and the functionality of a smart electronic system, capable of monitoring water quality parameters, in order to monitor the fish tanks’ environment and making decisions about undesirable events that may affect them. If unpleasant events occur, such as the parameter’s level no longer falls within the preseted limits, an alarm is set to warn the user. Automatization of the system will be conceived to close the power and/or water supply circuit in case there was no human intervention within a certain period of time in the fish tanks. This paper is based on the ongoing research of the iPREMAS aquaculture project. The system from the iPREMAS project contains sensors for monitoring the essential water quality parameters for the growth, reproduction and qualitative and quantitative improvement of fish population, such as pH level, water temperature, dissolved oxygen level, water salinity, water level, conductivity and will be improved with sensors to monitor the level of nitrates and nitrites. The sensors are to be connected to a special designed electronic module and will transmit the information to an electronic control module based on a development kit containing a microcontroller for the automatization of the system. A database is used to store the data and a software application is used to visualize the data transmitted by the sensors that will communicate with the database and display the values in real time.
Examining Partisan Reporting of Critical Race Theory Using Meta’s CrowdTangle
Authors:   University of Central Florida, United States of America, WRIGHT Chrysalis , COELHO Beatriz ,   University of Central Florida, United States of America, KOERNER Caitlyn ,   University of Central Florida, United States of America, FERRER Cristina ,   University of Central Florida, United States of America, RECHDAN Caitlin ,   University of Central Florida, United States of America, LARSON Donna ,   University of Central Florida, United States of America
Published: April 2023

Mainstream news media outlets can influence the opinions and attitudes of their audience based on how they frame information. This framing can also to polarization. Presently there exists partisan controversies and state-level legislation in the United States regarding Critical Race Theory (CRT). We examined partisan reporting related to CRT using Meta’s metrics platform, CrowdTangle and tracked Facebook posts by news media outlets from January 30, 2020, to January 30, 2022. We were interested in how mainstream news media reported on CRT and wanted to examine significant differences in consumers interactions with posts and page following from right-leaning, left-leaning, and neutral news media outlets. We also examined the overperformance of posts. We identified social media accounts that played a vital role in sharing content related to CRT and determined the potential impact of posts. We found that right-leaning news media were more likely to post about CRT, compared to left-leaning and neutral news media outlets, with reporting beginning in June 2020. Neutral and left-leaning news media outlets began reporting on CRT months later. Our results demonstrated that right-leaning news media outlets had more followers and more post interactions. We also found variations in user interactions based on the partisan nature of the news media. Additionally, neutral news media had higher overperformance scores compared to other outlets. Our findings will be beneficial to those involved in policy making regarding social media, media distrust, and race relations within the United States.
Marketing and Communication in Romania’s Next Sports Decade: Identifying Key Success Factors in the National Strategy for Sport 2023
Authors:   Babes-Bolyai University, Cluj-Napoca, Romania, CERGĂ Brîndușa-Maria
Published: April 2023

Sports in Romania is experiencing a surge of popularity and desire to improve in all areas, after years of decline in which the statics have raised concerns. Enabling this industry with a clear plan and raising the standards is paramount for the future development of the sports scene. In this context, the present paper aims to explore the National Sports Strategy of Romania (NSS23), with the objective of identifying key success factors related to marketing and communication and determining whether they can be measured against future success. A content analysis of the NNS23 was conducted. Compliant items include clear objectives and methods, a statement of ownership and responsibility, and the beneficiaries. The analysis revealed that the document is missing some data, such as limitations, terms of quality and resources, which must be included to measure the success of the strategy. Additionally, it was found that in its current form, the NSS23 cannot be accurately measured against future success due to the lack of financial and capacity resources related to marketing and communication. Suggested amendments can help to ensure that the strategy is complete and can be properly assessed against future success. Future research directions are proposed to explore the NSS23.
Transcatheter heterotopic valve implantation with the TricValve system: focus on preoperative assessment and patient selection
Authors: Nicolò Francesca , Russo Marco , Ranocchi Federico , Cammardella Antonio G. , Bellomo Francesca , Polizzi Vincenzo , Pergolini Amedeo , Sbaraglia Fabio , Lio Antonio , Musumeci Francesco
Published: April 2023

Nontreated severe symptomatic tricuspid valve regurgitation is associated with significant morbidity and mortality. When a surgical correction is not feasible due to high operative risk, transcatheter treatment of the tricuspid valve has been suggested as an interesting valuable option. Caval valve implantation has been proposed to overcome the tricuspid valve regurgitation mechanism reducing the effect of insufficiency on the splanchnic systems. Given the technical simplicity of the caval valve implantation technique when compared with other transcatheter devices, it is a suitable option for a wide variety of patients. Eligibility criteria and patient selection are still matter of debate. We hereby describe the case of a patient successfully treated with bicaval implants with regard to preoperative assessment.
Energy and emission properties of burley tobacco stalk briquettes and its combinations with other biomass as promising replacement for coal
Authors: Malnar Maja , Radojičić Vesna , Kulić Gordana , Dinić Zoran , Cvetković Olga
Published: April 2023

As a tobacco producer, Serbia has to deal with large amounts of leftover tobacco stalks after harvesting. One option for this type of biomass is to burn it, but burning is not encouraged in Serbia, since the levels of its combustion products have not been investigated yet. The aim of this study was therefore to determine the elemental composition, ash and nicotine content, heat values, and composition of gaseous combustion products of tobacco stalk briquettes and to see if their mixing with other types of biomass available in Serbia could improve their ecological profile. We made 11 different types of briquettes: six of pure raw materials, including burley tobacco stalks, sunflower head remains, wheat straw, corncob, soy straw, and beech sawdust and five by mixing tobacco stalks with these other raw materials in a 50:50 mass ratio. All briquettes meet the ecological criteria regarding the emission limits for nitrogen oxides (NOx), sulphur dioxide, carbon monoxide, and carbon dioxide. Nicotine content in flue gases (<10 mg/kg) is far below the maximum level allowed by the European Union. Heat values of all biomass samples are acceptable, although lower than those specified for solid biofuels (≥16.0 MJ/kg), save for corncob and beech sawdust and their mixtures with tobacco stalks. Our findings therefore encourage the use of tobacco stalks as a viable biofuel.
New in vitro findings about halogenated boroxine cytotoxicity and deregulation of cell death-related genes in GR-M melanoma cells
Authors: Elez-Burnjaković Nikolina , Pojskić Lejla , Haverić Anja , Lojo-Kadrić Naida , Omanović Maida Hadžić , Ramić Jasmin , Smajlović Ajla , Maksimović Milka , Haverić Sanin
Published: April 2023

Anti-proliferative effects of halogenated boroxine – K2(B3O3F4OH) (HB) – have been confirmed in multiple cancer cell lines, including melanoma, but the exact mechanism of action is still unknown. This study aimed to determine its cytotoxic effects on human Caucasian melanoma (GR-M) cell growth in vitro as well as on the expression of cell death-related genes BCL-2, BECN1, DRAM1, and SQSTM1. GR-M and peripheral blood mononuclear (PBM) cells were treated with different HB concentrations and their growth inhibition and relative gene expression profiles were determined using the Alamar blue assay and real-time PCR. HB significantly inhibited cell growth of both GR-M and PBM cells but was even more effective in GR-M melanoma cells, as significant inhibition occurred at a lower HB concentration of 0.2 mg/mL. GR-M BCL-2 expression was significantly downregulated (P=0.001) at HB concentration of 0.4 mg/mL, which suggests that HB is a potent tumour growth inhibitor. At the same time, it upregulated BCL-2 expression in normal (PBM) cells, probably by activating protective mechanisms against induced cytotoxicity. In addition, all but the lowest HB concentrations significantly upregulated SQSTM1 (P=0.001) in GR-M cells. Upregulated BECN1 expression suggests early activation of autophagy at the lowest HB concentration in SQSTM1 cells and at all HB concentrations in PBM cells. Our findings clearly show HB-associated cell death and, along with previous cytotoxicity studies, reveal its promising anti-tumour potential.