bluuebunny/crossref_metadata_2025 huggingface dataset:
Local Culture Welum Ba’hadat (Life In The Rules) In The Learning Process within Rural School
Authors: Eshariyani Eshariyani
Published: August 2024

This research aims to describe and give meaning to the local culture of Welum Ba’hadat (Living in Rules) in the learning process at the School of the Deserted Village. Research location at SMPN 7 South Dusun, Prefecture: South Dusan, District: South Barito, Central Kaliamantan Province. Using qualitative methods with phenomenal approaches that are oriented to theoretical. The data collection techniques used are participatory, observational, in-depth interviews, and document studies. The results of the analysis of this study found that the local culture is not in the process of learning in the village school remains in Barito South district, Central Kalimantan Province. The values that apply to a) the rules of conduct, b) the guidelines of behaviour, c) the philosophy, the behavior of local wisdom “not ba’adat” (Hidup dalam aturan).
Implementation of the Kotabaru Regency Social Service Policy Model in Empowering Vagrants and Beggars as an Effort for Social Rehabilitation through the Barakat Cangkal Becari Program
Authors: Sakerani Sakerani , As'ad Muhammad Uhaib , Rahayu Iswiyati
Published: August 2024

The "Barakat Cangkal Becari" program is a social rehabilitation program for homeless people and beggars by touching on rehabilitative aspects, preventive aspects, guarantees, social protection and empowerment. Barakat Cangkal Becari Program. has an element of renewal where activities will be provided to support skills. This research discusses the empowerment of homeless people and beggars as a social rehabilitation effort through the Barakat Cangkal Becari study program at the Kotabaru Regency Social Service. This research is descriptive qualitative in nature. Data collection was carried out by means of interviews, observation and documentation. The results of the research show that the empowerment efforts carried out by the Kotabaru Regency Social Service as social rehabilitation efforts include 1) Outreach and Repatriation of Homeless People and Beggars; 2) Physical, Mental and Social Guidance; 3) Skills Guidance; 4) UEP Stimulant Assistance; 5) Life Guarantee; 6) Stimulant Assistance; 7) Returning Homeless and Beggar Children to School; 7) Social Advocacy and Accessibility Development. Apart from that, there are stages of community empowerment, namely: 1) Stage of awareness and behavior formation; 2) Transformation stage; 3) Stage of increasing intellectual abilities, skill proficiency. Then the actors involved in the empowerment efforts carried out include:1) Social Services; 2) Social Rehabilitation Homes 3) Central Government Agencies; 4) Higher Education; 5) Private. The inhibiting factors that influence include: 1) Changing the mindset, mentality and attitude of WBS Barakat Cangkal Becari HR;2) Social Advocacy Efforts and Accessibility Development; 3) Location of the Barakat Cangkal Becari Program; 4) Lack of Facilities and Infrastructure. Meanwhile, supporting factors that influence include: 1) Sufficient funds for the empowerment process; 2) Good cooperation between stakeholders.Based on the explanation above, it can be concluded that the aim of empowerment is that WBS Barakat Cangkal Becari can be independent and carry out its social functions in community life. Efforts that can be made are:1) There is planning for empowerment activities every year; 2) There are indicators of success every year; 3) groups or work units consisting of several stakeholders; 4) Strengthening mental, social guidance, social advocacy, and developing accessibility; 5) Construction of facilities and infrastructure for social rehabilitation institutions in Kotabaru district.
Marketing Strategy for Red Ginger (Zingiber officinale) Cultivation in Rantau Balai Village, Aranio District, Banjar Regency
Authors: Hayati Maulida , Hidayatullah Arief , Ash'ari Fuzi Maulana
Published: August 2024

This research identifies internal and external factors influencing red ginger marketing in Rantau Balai Village, Aranio District, Banjar Regency, and proposes strategies to enhance its market potential. Using IFAS, EFAS, SWOT, and BMC analysis, the study finds that strengths (score: 1.81) exceed weaknesses (score: 1.15), and opportunities (score: -1.61) outweigh threats (score: -1.23), indicating favorable conditions. The farming is positioned in quadrant I, suggesting it is in a strong state, and an aggressive strategy is recommended. Proposed strategies include product diversification, strengthening industrial relations, optimizing supply chains, improving farmer education and training, and expanding marketing channels to enhance productivity and competitiveness.
Lo nacional-popular en Ecuador: una relación dialéctica
Authors: Pardo Moreno Pablo , Albert Márquez José Jesús
Published: August 2024

Introducción: El nacionalismo y el populismo han marcado la historia reciente de Latinoamérica, con Ecuador como un caso único. Los objetivos de este estudio son identificar a los actores políticos y de poder que han proyectado ideas de nación, y analizar la dialéctica entre los distintos sentidos de nación y la noción de "pueblo" en las luchas sociales de Ecuador en los últimos treinta años. Metodología: Se utilizó la dialéctica tanto como lente de observación del proceso como método de análisis para comprender el desarrollo del sentido de la nación ecuatoriana en relación a lo popular. La investigación se centra en una conceptualización de la dialéctica basada en el conflicto, utilizando perspectivas antagonistas como las de Heráclito, el materialismo y el iluminismo. Se realizó una revisión historiográfica de las últimas tres décadas de esfuerzos de construcción nacional por parte de actores políticos y movimientos sociales. Resultados: El estudio revela una constante disputa por el sentido de nación, evidenciada por síntomas como la inestabilidad política, la conflictividad social y el protagonismo de las Fuerzas Armadas como catalizador político en las crisis gubernamentales. Conclusiones: Tanto el nacionalismo como el populismo en Ecuador han tenido traducciones políticas e ideológicas que se reflejan en la inestabilidad y conflictividad política y social mencionadas.
НАПРЯМИ СТАЛОГО РОЗВИТКУ ЗАЛІЗНИЧНОГО ТРАНСПОРТУ УКРАЇНИ
Authors: МАРЦЕНЮК Лариса , ШНІПОВ Владислав
Published: August 2024

Окреслено напрями сталого розвитку залізниць задля досягнення сталого розвитку України та планети в цілому. Підкреслено, що в роботі транспортного відомства потрібно однаково приділяти увагу всім складовим сталого розвитку, як-от: економічній, соціальній, екологічній. Сталий розвиток залізниць досягається шляхом виконання багатьох завдань, котрі потрібно реалізувати топ-менеджменту, серед них: забезпечення безпеки руху поїздів, економічної безпеки, перехід на екологічно чистий рухомий склад, модернізація інфраструктури відповідно до світових тенденцій з урахуванням застосування «зелених» технологій, запровадження розумної мобільності, якісна організація соціальних перевезень, забезпечення безбар’єрності доступу до об’єктів залізничного транспорту, зниження плинності кадрів, залучення молоді та ін.
РОЗСЛІДУВАННЯ КРИМІНАЛЬНИХ ПРАВОПОРУШЕНЬ, ПОВ’ЯЗАНИХ ІЗ НЕЗАКОННИМ НАБУТТЯМ ПРАВА НА ЗЕМЛЮ ДЕРЖАВНОЇ АБО КОМУНАЛЬНОЇ ВЛАСНОСТІ: ПРОБЛЕМНІ ПИТАННЯ
Authors: ЄФІМОВ Микола , МИХАЙЛЕНКО Владислав
Published: August 2024

Досліджено проблемні питання розслідування кримінальних правопорушень, пов’язаних із незаконним набуттям права на землю державної або комунальної власності. Зазначено, що розслідування кримінальних правопорушень, пов’язаних із незаконним набуттям права на землю державної або комунальної власності, з року в рік набуває все більшого значення. Це зумовлено низкою чинників, як-от: збройна агресія нашого східного «сусіда»; слабкість правової системи; збільшення обігу холодної та вогнепальної зброї; низький рівень правової культури; деокупація окремих регіонів України. З огляду на вищеперераховані чинники протиправні діяння визначеної категорії вчинюються все частіше та частіше. Вказане спричиняє негативні перспективи розвитку в нашій державі комунального середнього та малого підприємництва. Запропоновано закріпити окремою нормою Кримінального кодексу України рейдерство як кримінальне правопорушення. Підтримується позиція стосовно необхідності виокремлення декількох статей в Кримінальному кодексі України, що будуть розкривати різні аспекти досліджуваного протиправного діяння. Надано власне формулювання рейдерства як системи діянь (дій та бездіяльності), направлених на протиправне захоплення майна (в тому числі земельних ділянок) приватних, комунальних та державних суб’єктів господарювання, а також встановлення контролю над ними та в подальшому – управління. Визначено заходи протидії зазначеному кримінальному правопорушенню: удосконалення корпоративного і процесуального законодавства, внесення змін до тих його положень, що мають двозначне трактування; виховання відповідальної економічної поведінки у суб’єктів економічних відносин; виховання у суб’єктів правовідносин правової культури; вдосконалення податкової системи, зменшення податкового тиску на підприємства, спрощення системи обліку; покращення підготовки фахівців відповідних правоохоронних органів з питань протидії рейдерським захопленням для незаконного набуття права на землю державної або комунальної власності.
УЧАСТЬ СПЕЦІАЛІСТІВ В ОГЛЯДІ МІСЦЯ ВЧИНЕННЯ ВОЄННОГО ЗЛОЧИНУ
Authors: ПАТИК Леся , ПАТИК Андрій , МИРОВСЬКА Анна
Published: August 2024

Розглянуто питання участі спеціалістів різних галузей в огляді місця вчинення воєнного злочину. Встановлено, що це такі спеціалісти: працівники пожежно-рятувальних підрозділів Державної служби з надзвичайних ситуацій, спеціалісти-вибухотехніки/сапери ЗСУ, кінологи зі службово-пошуковими собаками, психологи, спеціалісти-криміналісти, спеціалісти з питань застосування ракетних військ та артилерії, військової авіації, оператори безпілотних літальних апаратів, судово-медичні експерти та ін. Встановлено роль кожного з них у збиранні криміналістично значущої інформації для формування належної кількості доказів у суді. Наголошено на важливості залучення до огляду мобільних ДНК-лабораторій для швидкої ідентифікації тіл чи решток загиблих осіб.
ДИФЕРЕНЦІАЦІЯ ПІДХОДІВ ДО ВОГНЕВОЇ ПІДГОТОВКИ ПОЛІЦЕЙСЬКИХ ОКРЕМИХ ПІДРОЗДІЛІВ НАЦІОНАЛЬНОЇ ПОЛІЦІЇ УКРАЇНИ
Authors: НАТОЧІЙ Анатолій , РАБУШКО Назарій
Published: August 2024

Досліджено необхідність та доцільність розмежування принципів вогневої підготовки поліцейських Національної поліції України залежно від спеціалізації та особливостей покладених на них службових обов’язків з огляду на специфіку несення служби у зв’язку зі введенням правового режиму воєнного стану та повномасштабним вторгненням російської федерації на територію України. Окрему увагу приділено питанню доцільності створення окремих навчальних програм з вогневої підготовки у ЗВО зі специфічними умовами навчання, що здійснюють підготовку кадрів для підрозділів Національної поліції України.
ІМПЛЕМЕНТАЦІЯ ЗАРУБІЖНОГО ДОСВІДУ ЗАПОБІГАННЯ ТА ПРОТИДІЇ ДОМАШНЬОМУ НАСИЛЬСТВУ В УКРАЇНСЬКУ ПРАВОЗАСТОСОВНУ ПРАКТИКУ: НАПРЯМИ ТА ПЕРСПЕКТИВИ
Authors: ЛІКАРЕНКО Олександр
Published: August 2024

Здійснено аналіз та оцінку імплементації міжнародного досвіду у сфері запобігання та протидії домашньому насильству. Зосереджено увагу на вивченні та порівнянні нормативних та інституційних механізмів, що використовуються у різних країнах із метою боротьби із зазначеним явищем. Розглянуто практичний досвід низки зарубіжних країн, проаналізовано його придатність та ефективність для української системи. Детально розкрито основні аспекти імплементації міжнародного досвіду у контексті української дійсності, зокрема, управління превентивними програмами, захист прав жертв, підтримка сімейних структур. Звернено увагу на проблеми та перспективи впровадження найкращих практик зарубіжних країн у національну стратегію боротьби з домашнім насильством. Зроблено акцент на необхідності адаптації міжнародного досвіду з огляду на специфіку української ситуації, а також на важливості системного підходу та співпраці між усіма зацікавленими сторонами для досягнення успішних результатів у протидії домашньому насильству. До найбільш значущих шляхів імплементації позитивних надбань зарубіжного досвіду в українську правозастосовну практику запропоновано віднести: створення розгалуженої мережі притулків, кризових центрів, гарячих ліній за прикладом розвинених країн для забезпечення безпеки та психологічної допомоги жертвам насильства; активне залучення громадських організацій до розробки та реалізації програм протидії насильству, проведення інформаційних кампаній з підвищення обізнаності населення; впровадження корекційних програм для осіб, які вчиняють насильство, з метою зміни їхньої поведінки та попередження рецидивів; внесення змін до законодавства з метою криміналізації психологічного насильства як окремого злочину, адже в багатьох країнах психологічне насильство розглядається як кримінальне правопорушення, тощо.
ОБОВ’ЯЗОК ПОВНОЛІТНІХ ДІТЕЙ ПІКЛУВАТИСЯ ПРО СВОЇХ НЕПРАЦЕЗДАТНИХ БАТЬКІВ: ДИСКУСІЙНІ ТЕОРЕТИКО-ПРАВОВІ АСПЕКТИ
Authors: ПЕРЕПЬОЛКІН Сергій
Published: August 2024

Висвітлено дискусійні теоретико-правові аспекти характеристики обов’язку повнолітніх дітей піклуватися про своїх непрацездатних батьків та винесено для наукового обговорення авторське трактування такого обов’язку. Обґрунтовано думку щодо недоречності здійснення характеристики поняття обов’язку повнолітніх дітей піклуватися про своїх непрацездатних батьків на основі статей 202–206 Сімейного кодексу України, положення яких присвячені характеристиці обов’язку повнолітніх дочки, сина утримувати батьків. Під час розкриття поняття обов’язку повнолітніх дітей піклуватися про своїх непрацездатних батьків згадувати про складові інституту опіки та піклування доречно тільки в аспекті проведення порівняльно-правових досліджень.
ЗАРОДЖЕННЯ І РОЗВИТОК ІНСТИТУТУ АПЕЛЯЦІЙНОГО ОСКАРЖЕННЯ В ЦИВІЛЬНОМУ СУДОЧИНСТВІ НА УКРАЇНСЬКИХ ЗЕМЛЯХ
Authors: НЕСТЕРЦОВА-СОБАКАРЬ Олександра
Published: August 2024

Розглянуто основні аспекти появи і зародження на українських землях апеляційного оскарження, правові акти, котрі містили норми щодо можливості апеляції. Висвітлено декілька позицій дослідників щодо періодизації історії судочинства і процесу в Україні, існування інституту апеляційного оскарження. Зазначено, що серед дослідників історії держави і права, цивільного судочинства та апеляційного оскарження немає єдиної думки, коли на українських землях вперше з’явилася практика оскарження або перегляду судових рішень. Наведено твердження і аргументи дослідників, які наголошують на існуванні можливості оскаржити рішення судової інстанції ще за часів Русі, та тих, які наполягають на відсутності можливості в феодальній Русі та її державі-наслідниці Галицько-Волинському князівстві оскаржувати рішення судових інстанцій. Вказано на одностайність думок дослідників у цьому питанні щодо церковних судів. Висвітлено позиції науковців щодо появи інституту апеляційного оскарження за часів Великого князівства Литовського, Королівства Польського та в подальшому Речі Посполитої, а саме в артикулах трьох Литовських Статутів. Розглянуто норми другого і третього Литовських статутів, де вказувалося на тогочасне розуміння апеляції, строків її подання тощо. Акцентовано увагу на неофіційній кодифікації часів Гетьманщині, в якій містилися норми щодо апеляційного оскарження, змісту поняття, ієрархії судових інстанцій, причин відмов у апеляції, що мала назву «Права, за якими судиться малоросійський народ». Вказано, що зазначений акт увібрав у себе норми таких джерел права, як: Литовські статути, Зерцало Саксонське, Хелминське право; українське звичаєве право та судова практика; правотворча діяльність гетьмана та Генеральної військової ради; нормативно-правові акти гетьманської полково-сотенної публічної адміністрації та вищих органів влади: універсали, інструкції або розпорядження гетьмана, інструкції Генеральної військової канцелярії.
On partial stability in probability for nonlinear stochastic functional differential systems with aftereffect (delay)
Authors: Vorotnikov V. I. , Martyshenko Yu. G.
Published: August 2024

A system of nonlinear functional-differential equations with aftereffect (delay) subjected to random processes of “white” noise is considered. It is assumed that the system admits a “partial” (with respect to some part of the state variables) zero equilibrium position. The problem of stability in probability of a given equilibrium position is posed, and stability is considered not in all, but with respect to a part of the variables that determine this equilibrium position. For the solution of this problem, a stochastic version of the method of Lyapunov—Krasovskii functionals is used with the appropriated specification of the requirements for the functionals. In order to expend the capabilities of the method used, it is also proposed to correct the domain of the functional space in which auxiliary Lyapunov—Krasovskii functionals are constructed. Conditions for partial stability of this type are obtained. Examples are given that show the features of the proposed approach.
Aggregation of multidimensional conservative systems with oscillations
Authors: Barabanov I. N. , Tkhai V. N.
Published: August 2024

We consider the set of multidimensional conservative systems that admits a family of single-frequency oscillations when taken as a unified system. The problem of aggregation of a set of systems into a coupled system with an attractive cycle close to the oscillation of uncoupled systems is solved. Weak universal coupling controls are applied. Previously, the problem was solved for identical reversible one degree of freedom systems.
Interval estimation in discrete-time linear systems with parametric uncertainties
Authors: Zhirabok A. , Zuev A. , Kim C.
Published: August 2024

The problem of interval observer design for discrete-time linear systems under the external disturbances, measurement noise, and parametric uncertainties is studied. The relation allowing designing the interval observer of minimal dimension estimating the set of admissible values of the specified linear vector function of the system state are derived. Theoretical results are illustrated by the example.
Mathematical Literacy In Solving Hots-Based Problems On Spldv Material In Terms of Cognitive Style
Authors: Lively Wanodya Kirana Intan , Machromah Isnaeni Umi
Published: August 2024

The concept of mathematical aptitude pertains to an individual's capacity to articulate, elucidate, and employ mathematical principles in everyday scenarios. This investigation stemmed from concerns surrounding substandard levels of mathematical literacy, potentially stemming from students' inability to meet established benchmarks. The primary objective of this inquiry was to evaluate students' mathematical acumen in tackling HOTS-based challenges linked to SPLDV materials, while considering their cognitive inclinations. Employing a qualitative framework with a descriptive approach, the study centered on four eighth-grade students from SMP Negeri 3 Colomadu, comprising two individuals exhibiting a field-dependent cognitive style and two with a field-independent cognitive orientation. Data on the participants' mathematical proficiencies were gathered through a combination of assessment tools and interviews, complemented by a cognitive style questionnaire. The validity of the data was fortified through triangulation methodologies. Analysis ensued through three distinct phases: data reduction, presentation, and synthesis. The results showed that students with Field Dependent cognitive style type only fulfill one indicator of mathematical literacy, namely communication. While students with cognitive style type Field Independent able to meet all indicators of mathematical literacy well include communication, mathematization, representation, reasoning and argumentation, designing strategies to solve problems, as well as the use of operations, symbols, formal, and technical.
Students' Proportional Reasoning in Solving PISA Problems on Quantity Content: An Analysis from the Perspective of Mathematical Self-Efficacy
Authors: Windasari Fany Dania , Setyaningsih Nining
Published: August 2024

One of the abilities that students need to develop is proportional thinking. Mathematical problems and real-world situations involving the connection between numbers and comparisons need students to use their reasoning skills to reach conclusions. The purpose of this study is to characterize, in terms of self-efficacy, students' proportional reasoning skills when addressing quantity content PISA questions. The self-efficacy questionnaire, PISA questions on quantitative content, interview instructions, and documentation are among the instruments used in this descriptive qualitative study. The study's findings demonstrate that students with low self-efficacy struggle to meet proportional reasoning requirements, contemplate difficulties, and give up quickly out of fear of failing, Pupils rely on guesswork to solve issues instead than attempting to come up with novel solutions. Students with moderate self-efficacy can identify proportional quantities in problems and understand them, but they are not yet able to convert quantities into other forms. They can also use the appropriate strategy but are still hesitant and make mistakes when calculating. Students with moderate self-efficacy are eager to work on problems, but they give up easily when faced with challenging ones. However, despite their continued self-doubt, students continue to look for answers. Despite their restricted talents, students who possess strong self-efficacy are able to meet proportional reasoning markers. Students who have high self efficacy tend to have motivation, high enthusiasm and have confidence in their abilities, students will try to find new ideas to solve problems.
Efisiensi Perbankan Syariah Di Indonesia Dengan Stochasitic Frontier Analysis (SFA)
Authors: Setiyani Duwi , Karsono Lorena Dara Putri
Published: August 2024

This study aims to examine the effect of Total Assets, Third Party Funds and Operating Costs on Total financing and measure the efficiency level of Bank Aladin Syariah in the 2020-2022 period. This research uses a quantitative approach with a causal associative research type. The data used in this study comes from the financial statements of Bank Aladin Syariah. The results showed that partially Total Assets had a significant effect on Total Financing of Bank Aladin Syariah. While Third Party Funds and Operating Costs have no effect on Total Financing. The highest efficiency value of Bank Aladin Syariah according to the Stochastic Frontier Analysis method occurred in the 2022 period. The implication of the research results is that the Bank Aladin Syariah policy improves its operational performance by being able to rationalize its operating costs. The highest efficiency value in 2022, the bank can concentrate policies by maintaining and improving efficiency through sustainable policies, regular evaluation, and adaptation to changes in the business environment. Bank Aladin Syariah can ensure the sustainability and improvement of its operational performance
Chemotherapy induced alopecia in breast cancer patients: A monocentric prospective study
Authors: Ben Kridis Wala , Boudawara Olfa , Khanfir Afef
Published: August 2024

INTRODUCTION: Alopecia is one of the main adverse events of chemotherapy in breast cancer. However, its impact is often ignored and underestimated by clinicians. Our aim was to evaluate the quality of life of breast cancer patients with chemotherapy induced alopecia. METHODS: We conducted a prospective study including 72 breast cancer patients who developed alopecia on or after stopping chemotherapy in the last 6 months. Clinical information and characteristics of alopecia were assessed using a self-prepared questionnaire. DLQI score was used to evaluate patients’ quality of life. RESULTS: We interviewed a total of 72 women with a mean age of 53.5 ± 6 years. Alopecia appeared soon after the first course in 62.5%. All patients actively tried to hide induced hair fall (either by a hat in 6.9% or by a headscarf in 93.1%). Quality of life was impacted in 97.2% of patients with a median DLQI score of 6.5. Women who did not underwent mastectomy were significantly more bothered by hair loss than those who had radical surgery (78.1% vs 55%, p = 0.04). Working status was a significant predictor factor of a bad quality of life due to alopecia (100% in working women vs 58.3% in homemaker or retired patients, p = 0.006). CONCLUSION: Chemotherapy induced alopecia had a negative impact on quality of life of patients with breast cancer, especially in working women and those who did not have radical surgery. Prior wearing of headscarves did not impact significantly the DLQI score.
Clinical trial of arthroscopic debridement combined with functional exercise in the treatment of advanced knee osteoarthritis: A retrospective observational study
Authors: Huang Shiming , Wang Qiang , Chen Daohua , Zhan Peng , Chen Dongfeng
Published: August 2024

BACKGROUND: Advanced knee osteoarthritis (KOA) impacts both knees, resulting in pain, deformity, and substantial restrictions in joint mobility. OBJECTIVE: This study aims to examine the effectiveness of combining arthroscopic debridement with functional exercise in treating advanced KOA. METHODS: A total of 296 patients diagnosed with advanced KOA were divided into two groups: the observation group (n= 152) received arthroscopic debridement combined with functional exercise, while the control group (n= 144) underwent arthroscopic debridement only. The study compared and observed the outcomes between the two groups. RESULTS: There were no significant differences in knee joint function, inflammation level, and oxidative stress between the two groups before treatment (P> 0.05). Following treatment for six months, the observation group exhibited significantly lower visual analog scale (VAS) score, tissue inhibitors of metalloproteinase-1 (TIMP-1), tumor necrosis factor-alpha (TNF-α), interleukin-1 (IL-1), matrix metalloproteinase-3 (MMP-3), and malondialdehyde (MDA) levels compared to the control group (P< 0.05). Meanwhile, the observation group showed significantly higher levels of Lysholm score, hospital for special surgery (HSS) score, range of motion (ROM) of knee, peak torque (PT) and total work (TW) for knee extension and flexion, superoxide dismutase (SOD), total antioxidant capacity (T-AOC), and glutathione (GSH) compared to the control group (P< 0.05). Besides, the effective treatment rate in the observation group was notably higher than that in the control group (80.92% vs. 69.44%, P< 0.05). CONCLUSION: The combination of arthroscopic debridement with functional exercise is an effective treatment for advanced KOA. This approach not only enhances the function and strength of knee joint and reduces inflammatory response but also boosts the body’s antioxidant capacity. The treatment exhibits encouraging outcomes and warrants broad implementation.
The relationship between smartphone usage position, pain, smartphone addiction, and hand function
Authors: Depreli Ozde , Angin Ender
Published: August 2024

BACKGROUND: The hand is the most frequently used part of the body during daily life activities. Any musculoskeletal problem that may occur in the hand can lead to loss of function. OBJECTIVE: This study examined the relationship between the wrist and elbow position adapted during smartphone use, pain and discomfort, smartphone addiction, and hand function. METHODS: Pain and discomfort were evaluated with the visual analog scale, wrist and elbow angle during phone use were evaluated with a universal goniometer, smartphone addiction was evaluated with the Smartphone Addiction Scale-Short Version, and functional status of the hand was evaluated with the Michigan Hand Outcomes Questionnaire. RESULTS: A total of 120 university students (female: n= 60), with an average age of 22.71 ± 2.7 years, were included in this cross-sectional study. A relationship was found between the angle of the wrist and elbow during smartphone use and pain/discomfort (r= 0.692, p= 0.001), smartphone addiction (r= 0.575, p= 0.001), and hand function parameters (r= 0.20–0.55, p⩽ 0.05). CONCLUSION: Due to the increased use of smartphones in today’s environment, a preventive program should be developed in which texting for extended periods is avoided, along with frequent breaks to rest the hands, and stretching exercises for the upper extremities during rest.
The paradoxical role of transforming growth factor-β in controlling oral squamous cell carcinoma development
Authors: Peng Ruiting , Huang Yun , Huang Ping , Liu Linyi , Cheng Lei , Peng Xian
Published: August 2024

Transforming growth factor-[Formula: see text] (TGF-[Formula: see text]) is a multifunctional cytokine that plays a vital role in regulating cell growth, differentiation and survival in various tissues. It participates in a variety of cellular processes, including cell apoptosis, cell migration and evasion, and plays a paradoxical role in tumor genesis and development. In the early stage of tumor, TGF-[Formula: see text] inhibits the occurrence of tumor by inhibiting cell proliferation and regulating cell apoptosis. In the advanced stage of tumor, TGF-[Formula: see text] promotes tumor development and affects prognosis by promoting cell survival and proliferation, cell migration and invasion, participates in immune escape, etc. In this article, we will review the paradoxical role of TGF-[Formula: see text] on the occurrence and development of oral squamous cell carcinoma.
Glutaminase 1 plays critical roles in myelodysplastic syndrome and acute myeloid leukemia cells
Authors: Okabe* Seiichi , Moriyama Mitsuru , Arai Yuya , Gotoh Akihiko
Published: August 2024

BACKGROUND:

Myelodysplastic syndrome (MDS) features bone marrow failure and a heightened risk of evolving into acute myeloid leukemia (AML), increasing with age and reducing overall survival. Given the unfavorable outcomes of MDS, alternative treatments are necessary. Glutamine, the most abundant amino acid in the blood, is metabolized first by the enzyme glutaminase (GLS).

OBJECTIVES:

To investigate whether GLS is involved in the progression of MDS. The efficacy of GLS inhibitors (CB839 or IPN60090) and BCL2 inhibitor venetoclax was also examined.

METHODS:

We employed GLS inhibitors (CB839, IPN60090) and the BCL2 inhibitor venetoclax, prepared as detailed. MDS and AML cell lines were cultured under standard and modified (hypoxic, glutamine-free) conditions. Viability, proliferation, and caspase activity were assessed with commercial kits. RT-PCR quantified gene expression post-shRNA transfection. Mitochondrial potential, ATP levels, proteasome activity, and metabolic functions were evaluated using specific assays. Statistical analyses (t-tests, ANOVA) validated the findings.

RESULTS:

The glutamine-free medium inhibited the growth of MDS cells. GLS1 expression was higher in AML cells than in normal control samples (GSE15061), whereas GLS2 expression was not. Treatment of MDS and AML cells for 72 h was inhibited in a dose-dependent manner by GLS inhibitors. Co-treatment with the B-cell lymphoma 2 (BCL2) inhibitor venetoclax and GLS inhibitors increased potency. Cells transfected with GLS1 short hairpin RNA showed suppressed proliferation under hypoxic conditions and increased sensitivity to venetoclax.

CONCLUSIONS:

Targeting glutaminolysis and BCL2 inhibition enhances the therapeutic efficacy and has been proposed as a novel strategy for treating high-risk MDS and AML.
EMP3: A promising biomarker for tumor prognosis and targeted cancer therapy
Authors: Zhu Wenjing , Song Shu , Xu Yangchun , Sheng Hanyue , Wang Shuang
Published: August 2024

Epithelial membrane protein 3 (EMP3) belongs to the peripheral myelin protein 22 kDa (PMP22) gene family, characterized by four transmembrane domains and widespread expression across various human tissues and organs. Other members of the PMP22 family, including EMP1, EMP2, and PMP22, have been linked to various cancers, such as glioblastoma, laryngeal cancer, nasopharyngeal cancer, gastric cancer, breast cancer, and endometrial cancer. However, few studies report on the function and relevance of EMP3 in tumorigenicity. Given the significant structural similarities among members of the PMP22 family, there are likely potential functional similarities as well. Previous studies have established the regulatory role of EMP3 in immune cells like T cells and macrophages. Additionally, EMP3 is found to be involved in critical signaling pathways, including HER-2/PI3K/Akt, MAPK/ERK, and TGF-beta/Smad. Furthermore, EMP3 is associated with cell cycle regulation, cellular proliferation, and apoptosis. Hence, it is likely that EMP3 participates in cancer development through these aforementioned pathways and mechanisms. This review aims to systematically examine and summarize the structure and function of EMP3 and its association to various cancers. EMP3 is expected to emerge as a significant biological marker for tumor prognosis and a potential target in cancer therapeutics.
Identification of DNA methylation-regulated WEE1 with potential implications in prognosis and immunotherapy for low-grade glioma
Authors: Zhong Wang-Jing , Zhang Li-Zhen , Yue Feng , Yuan Lezhong , Zhang Qikeng , Li Xuesong , Lin Li
Published: August 2024

BACKGROUND:

WEE1 is a critical kinase in the DNA damage response pathway and has been shown to be effective in treating serous uterine cancer. However, its role in gliomas, specifically low-grade glioma (LGG), remains unclear. The impact of DNA methylation on WEE1 expression and its correlation with the immune landscape in gliomas also need further investigation.

METHODS:

This study used data from The Cancer Genome Atlas (TCGA), Chinese Glioma Genome Atlas (CGGA), and Gene Expression Omnibus (GEO) and utilized various bioinformatics tools to analyze gene expression, survival, gene correlation, immune score, immune infiltration, genomic alterations, tumor mutation burden, microsatellite instability, clinical characteristics of glioma patients, WEE1 DNA methylation, prognostic analysis, single-cell gene expression distribution in glioma tissue samples, and immunotherapy response prediction based on WEE1 expression.

RESULTS:

WEE1 was upregulated in LGG and glioblastoma (GBM), but it had a more significant prognostic impact in LGG compared to other cancers. High WEE1 expression was associated with poorer prognosis in LGG, particularly when combined with wild-type IDH. The WEE1 inhibitor MK-1775 effectively inhibited the proliferation and migration of LGG cell lines, which were more sensitive to WEE1 inhibition. DNA methylation negatively regulated WEE1, and high DNA hypermethylation of WEE1 was associated with better prognosis in LGG than in GBM. Combining WEE1 inhibition and DNA methyltransferase inhibition showed a synergistic effect. Additionally, downregulation of WEE1 had favorable predictive value in immunotherapy response. Co-expression network analysis identified key genes involved in WEE1-mediated regulation of immune landscape, differentiation, and metastasis in LGG.

CONCLUSION:

Our study shows that WEE1 is a promising indicator for targeted therapy and prognosis evaluation. Notably, significant differences were observed in the role of WEE1 between LGG and GBM. Further investigation into WEE1 inhibition, either in combination with DNA methyltransferase inhibition or immunotherapy, is warranted in the context of LGG.
Cost benefit of academic mobility, brain drain and migration: Western balkans in a crossroad
Authors: Kacani Jolta , Trunk Aleš , Qorraj Gazmend , Shaqiri Gentjan
Published: August 2024

Background

In recent years, Albania, Bosnia and Herzegovina, and Kosovo have witnessed a notable increase in the number of skilled individuals, including healthcare professionals, seeking employment outside the country.

Objective

This paper’s research objective is to determine the factors influencing the brain drain of young individuals who work abroad based on the migration push and pull factors of healthcare professionals in Albania, Bosnia and Herzegovina, and Kosovo.

Methods

This paper combines a qualitative and quantitative research design. Data was generated via a questionnaire addressed to 300 young healthcare professionals. In addition, logistic regression was selected to evaluate future migration intentions.

Results

One of this paper’s main findings is that young healthcare professionals cannot make a sound judgment on whether remuneration in the destination country will improve their situation.

Conclusions

The absence of accounting literacy is one of the main factors in young professionals’ poor judgment. The negative correlation between home country opportunities and migration intentions appeals to significant reforms in the health care sector to deter brain drain from the Western Balkan region.
Industrial mechanical equipment fault detection and high-performance data analysis technology based on the Internet of Things
Authors: Ding Dawei
Published: August 2024

In view of the problems of low detection accuracy, long detection time, and inability to monitor fault data in real time in the fault detection of traditional machinery and equipment, this paper studies the identification and fault detection of industrial machinery based on the Internet of Things (IoT) technology. By using Internet of Things technology to build a mechanical equipment fault detection system, Internet of Things technology can better build diagnostic and early warning modules for the system, so as to achieve the goal of improving the accuracy of equipment fault detection, shortening equipment fault detection time, and remotely monitoring equipment. The fault detection system studied in this paper has an accuracy rate of more than 93.4% to detect different types of fault. The use of Internet of Things technology is conducive to improving the accuracy of mechanical equipment fault detection and realizing real-time monitoring of equipment data.
Optimization of distribution paths in cold chain logistics management based on IFW-ABC algorithm
Authors: Zhao Mei
Published: August 2024

The current cold chain logistics management and distribution routes generally face problems such as environmental pollution and high costs. Therefore, the study proposed an improved fireworks-artificial bee colony for optimizing delivery paths. Firstly, the artificial bee colony was improved by using neighborhood search. Secondly, for the optimal solution, the fireworks explosion operator was used for the final result search. The benchmark function validation showed that the proposed algorithm performed better than other algorithms in solving optimal value, average value, and standard deviation. In the simulation analysis of a fresh enterprise in China, the total delivery cost was reduced by an average of 3.30% and 4.93% compared to other algorithms, considering carbon emission and not considering it, respectively. This proposed algorithm had more advantages in reducing quality loss, pollutant emissions, and CE. Therefore, this improved fireworks-artificial bee colony can effectively reduce the economic costs and environmental pollution of cold chain logistics distribution routes. This ensures economic benefits while considering social benefits, achieving the optimal path planning for logistics distribution.
Intelligent distribution network fault monitoring integrating differential evolution and chaos whale optimization algorithm
Authors: Liu Meng , Liu Xuan , Han Xueying
Published: August 2024

Faced with rapid development and increasingly complex power grid structure structure of the power grid, it is necessary to accurately locate faults in modern intelligent distribution networks in order to ensure power supply reliability and improve power supply service quality. Aiming at the low positioning accuracy, long time consumption, and limited coverage types in existing positioning algorithms, a new intelligent distribution network fault positioning algorithm is designed by combining two algorithms to complete the monitoring task. Firstly, intelligent distribution network fault location methods under different distributed power grid connection methods are analyzed. Then, considering the distributed power grid connection, a fault location algorithm is designed by combining differential evolution algorithm, Sine chaotic mapping, and whale algorithm. The research results indicated that the designed method had good benchmark performance, with accuracy and recall values as high as 0.98 and 0.97, respectively. During the training process, it only required 175 iterations to reach a stable state. In practical applications, the accuracy of this algorithm in testing three types of faulty power grids was 98.90%, 98.41%, and 98.25%, respectively. The method can effectively improve the fault location accuracy, providing better positioning technology for fault monitoring problems in power systems.
A comprehensive review of retinal disease diagnosis and open access datasets: Fundus and OCT images
Authors: Fatima Zameer , Dhaliwal Parneeta , Gupta Deepak
Published: August 2024

The rapid advancements in deep learning algorithms and the availability of large, open-access databases of fundus and OCT (optical coherence tomography) images have contributed greatly to advancements in computer-assisted diagnostics and the localization of various disorders affecting the retina. This study offers a comprehensive examination of retinal diseases and various recent applications of deep learning strategies for categorising key retinal conditions, such as diabetic retinopathy, glaucoma, age-related macular degeneration, choroidal neovascularization, retinal detachment, media haze, myopia, and dry eyes. Open-access datasets continue to play a critical role in the advancement of digital health research and innovation within the field of ophthalmology. Thirty open-access databases containing fundus and OCT (optical coherence tomography) pictures, which are often utilised by researchers, were carefully examined in this work. A summary of these datasets was created, which includes the number of images, dataset size, and supplementary items in the dataset, as well as information on eye disease and country of origin. We also discussed challenges and limitations of novel deep learning models. Finally, in conclusion, we discussed some important insights and provided directions for future research opportunities.
Normative Scores on the Clock Drawing Test Among Older Adults from a Large Population Survey in Norway: The HUNT Study
Authors: Engedal Knut , Benth Jūratė Šaltytė , Wagle Jørgen , Gjøra Linda , Selbæk Geir , Persson Karin
Published: August 2024

Background:

The Clock Drawing Test (CDT) is used to screen for Alzheimer’s disease and other dementia disorders. Normative scores on the version from the Montreal Cognitive Assessment (MoCA) do not exist in the Nordic countries.

Objective:

To examine the normative scores of the CDT among adults aged 70 years and older.

Methods:

We included 4,023 cognitively healthy persons aged 70–97 years from a population survey in Norway. They were examined with the CDT, which has a total score between zero and three. A multiple multinominal regression model was applied with a CDT score as the dependent categorical variable and estimated the probabilities of scoring a particular score, stratified by age, sex, and education. These probabilities correspond to an expected proportion of the normative population scoring at, or below a given percentile.

Results:

None scored zero, 2.1% scored one, 14.9% scored two, and 83% scored three. Higher age, female sex and fewer years of schooling were associated with poorer performance. Scores of zero and one deviated from the normative score regardless of age, sex and education. A score of two was within the norm for a female older than 81 and a male older than 85.

Conclusions:

The majority (83%) of people 70 years and older had a score of three on the CDT. Lower age, male sex, and higher education were associated with a better performance. Scores of zero and one were below the normative score. Except for the very old, a score of two was also well below the normative score.
Normative data for verbal fluency and naming tests in Spanish-speaking adults in the United States
Authors: Olabarrieta-Landa Laiene , Rivera Diego , Xia Bridget , Moreno Oswaldo , Ramos Usuga Daniela , Morel Valdés Gloria M. , Lopez Enrique , Rodriguez Miriam J. , Carrión Carmen I. , Lequerica Anthony H. , Drago Christin I. , García Patricia , Rivera Patricia M. , Perrin Paul B. , Arango-Lasprilla Juan Carlos
Published: August 2024

BACKGROUND: Linguistic deficits are common across neurological and neurodegenerative disorders. Currently there are limited neuropsychological norms available for Spanish-speaking adults residing in the U.S. OBJECTIVE: To generate norms for two verbal fluency tests and the Boston Naming Test (BNT) in a Spanish-speaking population in the U.S., with adjustments for demographic and cultural variables. METHODS: The sample consisted of 245 adults from the U.S. Participants completed phonological and semantic verbal fluency tests and the BNT. A standardized four-step statistical procedure was used. RESULTS: For the phoneme F, interactions between Spanish proficiency, age, and education arose. Better performance on phonemes A, S, and M was related to education. Spanish proficiency, acculturation, and time in the U.S. were associated with the phonemes S, A, P, M, and R. An age by education interaction was found for phonemes M and R. The FAS and PMR triads were related to age, sex, time in U.S., and Spanish proficiency. For the semantic verbal fluency tests, an interaction between education and Spanish proficiency arose. For the BNT, test scores were related to education, and significant interactions were also found based on education’s interaction with Spanish proficiency and acculturation. CONCLUSION: This study highlights the importance of accounting for sociodemographic and acculturative factors when developing normative data for verbal fluency tests and the BNT for dominant Spanish-speaking adults in the U.S. These sociodemographically-adjusted norms will help improve accuracy of diagnosis and interpretation of linguistic test performance in Spanish speakers living in the U.S.