bluuebunny/crossref_metadata_2025 huggingface dataset:
p53 engagement is a hallmark of an unfolded protein response in the nucleus of mammalian cells
Authors: Park Joseph H , Wandless Thomas J
Published: January 2025

Exposure to exogenous and endogenous stress is associated with the intracellular accumulation of aberrant unfolded and misfolded proteins. In eukaryotic cells, protein homeostasis within membrane-bound organelles is regulated by specialized signaling pathways, with the unfolded protein response in the endoplasmic reticulum serving as a foundational example. Yet, it is unclear if a similar surveillance mechanism exists in the nucleus. Here we leveraged engineered proteins called destabilizing domains to acutely expose mammalian cells to nuclear- or cytosolic- localized unfolded protein. We show that the appearance of unfolded protein in either compartment engages a common transcriptional response associated with the transcription factors Nrf1 and Nrf2. Uniquely, only in the nucleus does unfolded protein activate a robust p53-driven transcriptional response and a transient p53-independent cell cycle delay. These studies highlight the distinct effects of localized protein folding stress and the unique protein quality control environment of the nucleus.
Real-Time Closed-Loop Feedback System For Mouse Mesoscale Cortical Signal And Movement Control: CLoPy
Authors: Gupta Pankaj K , Murphy Timothy H
Published: January 2025

We present the implementation and efficacy of an open-source closed-loop neurofeedback (CLNF) and closed-loop movement feedback (CLMF) system. In CLNF, we measure mm-scale cortical mesoscale activity with GCaMP6s and provide graded auditory feedback (within ∼50 ms) based on changes in dorsal-cortical activation within regions of interest (ROI) and with a specified rule. Single or dual ROIs (ROI1, ROI2) on the dorsal cortical map were selected as targets. Both motor and sensory regions supported closed-loop training in male and female mice. Mice modulated activity in rule-specific target cortical ROIs to get increasing rewards over days (RM ANOVA p=2.83e-5) and adapted to changes in ROI rules (RM ANOVA p=8.3e-10, Table 4 for different rule changes). In CLMF, feedback was based on tracking a specified body movement, and rewards were generated when the behavior reached a threshold. For movement training, the group that received graded auditory feedback performed significantly better (RM-ANOVA p=9.6e-7) than a control group (RM-ANOVA p=0.49) within four training days. Additionally, mice can learn a change in task rule from left forelimb to right forelimb within a day, after a brief performance drop on day 5. Offline analysis of neural data and behavioral tracking revealed changes in the overall distribution of ΔF/F
0
values in CLNF and body-part speed values in CLMF experiments. Increased CLMF performance was accompanied by a decrease in task latency and cortical ΔF/F
0
amplitude during the task, indicating lower cortical activation as the task gets more familiar.
Plural molecular and cellular mechanisms of pore domain KCNQ2 encephalopathy
Authors: Abreo Timothy J , Thompson Emma C , Madabushi Anuraag , Park Kristen L , Soh Heun , Varghese Nissi , Vanoye Carlos G , Springer Kristen , Johnson Jim , Sims Scotty , Ji Zhigang , Chavez Ana G , Jankovic Miranda J , Habte Bereket , Zuberi Aamir R , Lutz Cathleen M , Wang Zhao , Krishnan Vaishnav , Dudler Lisa , Einsele-Scholz Stephanie , Noebels Jeffrey L , George Alfred L , Maheshwari Atul , Tzingounis Anastasios , Cooper Edward C
Published: January 2025

KCNQ2 variants in children with neurodevelopmental impairment are difficult to assess due to their heterogeneity and unclear pathogenic mechanisms. We describe a child with neonatal-onset epilepsy, developmental impairment of intermediate severity, and KCNQ2 G256W heterozygosity. Analyzing prior KCNQ2 channel cryoelectron microscopy models revealed G256 as a node of an arch-shaped non-covalent bond network linking S5, the pore turret, and the ion path. Co-expression with G256W dominantly suppressed conduction by wild-type subunits in heterologous cells. Ezogabine partly reversed this suppression. Kcnq2G256W/+ mice have epilepsy leading to premature deaths. Hippocampal CA1 pyramidal cells from G256W/+ brain slices showed hyperexcitability. G256W/+ pyramidal cell KCNQ2 and KCNQ3 immunolabeling was significantly shifted from axon initial segments to neuronal somata. Despite normal mRNA levels, G256W/+ mouse KCNQ2 protein levels were reduced by about 50%. Our findings indicate that G256W pathogenicity results from multiplicative effects, including reductions in intrinsic conduction, subcellular targeting, and protein stability. These studies provide evidence for an unexpected and novel role for the KCNQ2 pore turret and introduce a valid animal model of KCNQ2 encephalopathy. Our results, spanning structure to behavior, may be broadly applicable because the majority of KCNQ2 encephalopathy patients share variants near the selectivity filter.
Rab10 regulates neuropeptide release by maintaining Ca2+ homeostasis and protein synthesis
Authors: Dong Jian , Chen Miao , van Weering Jan RT , Li Ka Wan , Smit August B , Toonen Ruud F , Verhage Matthijs
Published: January 2025

Dense core vesicles (DCVs) transport and release various neuropeptides and neurotrophins that control diverse brain functions, but the DCV secretory pathway remains poorly understood. Here, we tested a prediction emerging from invertebrate studies about the crucial role of the intracellular trafficking GTPase Rab10, by assessing DCV exocytosis at single-cell resolution upon acute Rab10 depletion in mature mouse hippocampal neurons, to circumvent potential confounding effects of Rab10’s established role in neurite outgrowth. We observed a significant inhibition of DCV exocytosis in Rab10-depleted neurons, whereas synaptic vesicle exocytosis was unaffected. However, rather than a direct involvement in DCV trafficking, this effect was attributed to two ER-dependent processes, ER-regulated intracellular Ca
2+
dynamics and protein synthesis. Gene ontology analysis of differentially expressed proteins upon Rab10 depletion identified substantial alterations in synaptic and ER/ribosomal proteins, including the Ca
2+
-pump SERCA2. In addition, ER morphology and dynamics were altered, ER Ca
2+
levels were depleted and Ca
2+
homeostasis was impaired in Rab10-depleted neurons. However, Ca
2+
entry using a Ca
2+
ionophore still triggered less DCV exocytosis. Instead, leucine supplementation, which enhances protein synthesis, largely rescued DCV exocytosis deficiency. We conclude that Rab10 is required for neuropeptide release by maintaining Ca
2+
dynamics and regulating protein synthesis. Furthermore, DCV exocytosis appeared more dependent on (acute) protein synthesis than synaptic vesicle exocytosis.
Partitioning changes in ecosystem productivity by effects of species interactions in biodiversity experiments
Authors: Tao Jing , Nock Charles A , Searle Eric B , Huang Shongming , Man Rongzhou , Yang Hua , Freschet Grégoire T , Violle Cyrille , Zheng Ji
Published: January 2025

Species interactions affect ecosystem productivity. Positive interactions (resource partitioning and facilitation) increase productivity while negative interactions (species interference) decrease productivity relative to the null expectations defined by monoculture yields. Effects of competitive interactions (resource competition) can be either positive or negative. Distinguishing effects of species interactions is therefore difficult, if not impossible, with current biodiversity experiments involving mixtures and full density monocultures.To partition changes in ecosystem productivity by effects of species interactions, we modify null expectations with competitive growth responses, i.e., proportional changes in individual size (biomass or volume) expected in mixture based on species differences in growth and competitive ability. We use partial density (species density in mixture) monocultures and the competitive exclusion principle to determine maximum competitive growth responses and full density monoculture yields to measure species ability to achieve maximum competitive growth responses in mixture. Deviations of observed yields from competitive expectations represent the effects of positive/negative species interactions, while the differences between competitive and null expectations reflect the effects of competitive interactions.We demonstrate the effectiveness of our competitive partitioning model in distinguishing effects of species interactions using both simulated and experimental species mixtures. Our competitive partitioning model enables meaningful assessments of species interactions at both species and community levels and helps disentangle underlying mechanisms of species interactions responsible for changes in ecosystem productivity and identify species mixtures that maximize positive effects.
Reducing failures in electronic boards of CNC machines: EMI filter implementation for operational performance improvement
Authors: Santos James Silva dos , Brito Junior Jorge de Almeida , Leite Jandecy Cabral , Alencar David Barbosa de , Nascimento Manoel Henrique Reis , Queiroz Júnior Fernando Cardoso de
Published: January 2025

This study addresses performance improvement in Okuma CNC machines, focusing on reducing failures in electronic boards caused by electromagnetic interference (EMI) in the manufacturing environment of Musashi da Amazônia Ltda. The research is justified by the impact of these failures on the company's productive efficiency and maintenance costs. The primary objective was to identify the causes of frequent board failures and implement an effective intervention to mitigate the issue. The methodology included analyzing historical failure data and identifying EMI sources, leading to the installation of specific EMI filters. This solution significantly reduced failures, lowered maintenance costs, and improved the operational stability of the CNC machines. The study highlights the importance of managing power quality and offers a reference for industries facing similar challenges.
Analytical Hierarchy Process for Ranking E-Commerce Portals - A Case Study of Fashion Industry in India
Authors: Vuyyuru Mohit Reddy , Prasad A.V.S.
Published: January 2025

In recent years, the rise of online shopping has become a crucial aspect of the overall consumer purchasing experience. Shoppers now possess the ability to acquire a diverse range of products via the internet, significantly transforming their buying habits. As a result, it is essential for retailers to improve the customer shopping experience by facilitating seamless transactions and creating visually appealing websites. The prosperity of an online retail enterprise largely depends on the quality of its platforms, which must effectively attract potential buyers. Assessing the quality of e-commerce platforms poses a complex decision-making challenge, as it involves both qualitative and quantitative factors. This study proposes the use of the Analytic Hierarchy Process (AHP) technique to prioritize various e-commerce platforms. This approach will be applied to several leading Indian e-commerce sites to assess their influence on customer experience.
From Farm to Market: Unravelling the Volatility of Tomato Prices in India
Authors: S. K Rhamya.
Published: January 2025

Tomato is one of the most important crops in the horticulture sector with a share of ten percent in India. Tomato is essential to provide money for growers, employment opportunities, household and nutritional dietary requirements. Even through it has higher benefits, there are certain conditions like inadequate post-harvest practices, such as improper storage, poor marketing and transportation, and inadequate processing and preservation facilities which affect the tomato production and its supply and those conditions make a glut in market. Due to those condition, there is a price volatility of tomato in the market which affects the farmers, traders and consumers at greater extend. There is a finding that the price inflation occurs in the period of July to August and lower price during December to March as seasonality plays major role. The pre-production, production, harvesting, primary processing, packaging, interventions throughout the value chain, marketing and involvement of government are much needed to reduce the price volatility of tomato.
Assessing the causality between frailty and epilepsy: Bidirectional two-sample Mendelian randomization: Causal link between frailty and epilepsy
Authors: Wang Yan , Chen Ling
Published: January 2025

Background:

While a potential connection between epilepsy and frailty has been proposed in past research, the causal nature of this relationship requires additional study.

Objective:

This research was designed to evaluate the bidirectional causality between epilepsy and frailty index (FI) through two-sample Mendelian randomization (MR).

Methods:

In this study, we applied genome-wide association studies (GWAS) to perform forward and reverse MR within a two-sample context to explore the potential bidirectional causality between FI and epilepsy. The main analysis approach was the inverse variance weighted (IVW), used to assess the potential influence of causal relationships and to carry out sensitivity checks.

Results:

MR analysis has revealed a positive correlation between FI and the heightened risk of epilepsy (ORIVW = 1.2126, 95% CI: 1.0143-1.4497, P = 0.0343). This correlation persists in MR analysis that excluded aberrant single nucleotide polymorphisms (SNPs)(ORIVW = 1.1862, 95% CI: 1.0236-1.3746, P = 0.0232). Reverse MR analysis corroborated a significant positive relationship between epilepsy and FI (ORIVW =1.0896, 95% CI: 1.0242-1.1592, P = 0.0066), which was confirmed in subsequent replication analysis (ORIVW =1.0975, 95% CI: 1.0532-1.1436, P = 9.69e-06). Sensitivity analysis further supported the hypothesis of a causal link between FI and epilepsy.

Conclusion

There is an evident bidirectional causal relationship between FI and epilepsy.
Effect of internal fixation combined with inferior tibiofibular ligament repair on healing quality of ankle fracture with inferior tibiofibular joint injury
Authors: Ye Li , Pei Lei , Liu Qiang
Published: January 2025

Objective

To investigate the clinical effect of internal fixation combined with anterior ligament repair of lower tibiofibular syndesmosis in the treatment of ankle fracture with lower tibiofibular syndesmosis injury.

Methods

From November 2017 to December 2021, 94 patients with ankle fracture and lower tibiofibular syndesmosis injury were selected as the research objects. According to the random number table generated by statistical software, the patients with ankle fracture and lower tibiofibular syndesmosis injury were divided into combined group and control group, with 47 cases in each group. The patients in the combined group were treated with internal fixation combined with anterior ligament repair of lower tibiofibular syndesmosis, while the patients in the control group were treated with internal fixation combined with lower tibiofibular syndesmosis fixation. The operation time, bleeding volume, hospitalization time and fracture healing time of the two groups were compared.

Results

The operation time of the combined group was longer than that of the control group (P<0.05). The amount of bleeding, hospitalization time and fracture healing time of the two groups were compared and analyzed (P>0.05). The parameters of the lower tibiofibular space and the parameters of the lower tibiofibular overlap were compared between the combined group and the control group before operation, 3 months and 6 months after operation. The parameters of the lower tibiofibular space in the combined group were lower than those in the control group at 3 months and 6 months after operation, and the parameters of the lower tibiofibular overlap at 3 months after operation were higher than those in the control group (P<0.05)

Conclusion

Internal fixation combined with anterior ligament repair of lower tibiofibular syndesmosis in the treatment of ankle fracture with lower tibiofibular syndesmosis injury. Although the operation time is prolonged, it has a considerable effect on improving the reduction effect, promoting the recovery of joint function and reducing surgical complications.
Desequilíbrios no Investimento Federal em Educação, Ciência, Tecnologia e Inovação entre os Estados e as Consequências para os Sistemas Locais e Regionais de Inovação
Authors: Segundo Gesil Sampaio Amarante , Goulart Luciane Aparecida
Published: January 2025

Neste trabalho são comparados os investimentos realizados pela União e pelos estados em ensino superior e técnico nas fundações estaduais de amparo à pesquisa e na distribuição de bolsas do CNPq e Capes em oito estados das Regiões Sul, Sudeste e Nordeste, de forma a identificar eventuais desequilíbrios regionais. Tal comparação foi realizada por meio do acesso aos portais de transparência dos governos federal e dos estados, além das agências supracitadas, páginas oficiais das instituições e IBGE. Os dados coletados mostram que o país não caminha para a eliminação dos desequilíbrios entre regiões e, em alguns aspectos, particularmente no que diz respeito ao investimento em inovação, tais desequilíbrios têm aumentado. Percebe-se também um variado conjunto de estratégias estaduais adotadas ao longo do tempo.
Como fazer uma etnografia de modo participante
Authors: Lopes Ângelo Germano Lopes , De Carvalho Cavalcante Olendina
Published: January 2025

O presente artigo tem como objetivos principais descrever o processo de imersão em campo e explorar a construção de uma relação de confiança mútua, fundamental para a condução de uma pesquisa etnográfica participante. Para alcançar tais objetivos, será realizada uma pesquisa bibliográfica sobre metodologias nas ciências sociais, com ênfase na antropologia e na prática etnográfica. A base dessa pesquisa será a experiência em campo adquirida durante a elaboração da dissertação. O artigo detalha a dinâmica e a organização de três espaços de sociabilidade denominados “maticas”, com o intuito de identificar os passos essenciais para iniciar um estudo em campo. A etnografia, mais do que um método, possibilita a coleta de dados concomitante à elaboração de teorias. No entanto, destaca-se que a prática etnográfica não segue um manual ou receita padronizada; cada contexto exige uma abordagem sensível e adaptada às particularidades dos interlocutores e do ambiente. A abordagem proposta por Clifford Geertz (1989), que enfatiza a descrição densa, será seguida. Geertz sugere que se deve pesquisar nos espaços e, simultaneamente, interpretar em um nível mais profundo a cultura dos participantes.
An Experimental Study On The Effect Of Feed Varieties On Weight Of Broilers Species
Authors: Masopa Adekunle Nurudeen , Olatidoye Waheed Yinka , Ibrahim Rasheedat Adenike , Ajayi Yetunde Oyindamola
Published: January 2025

This study was aimed to examine the effect of feed types on species of broiler with attention on the weight gain
over a period of 6 weeks. Five varieties of feeds were administered on 2 units each of Marshall and Ross 308
and weights gained for the duration of the investigation were recorded. The factorial design involved feed
varieties and specie as the two factors. Granulated maize was used as control and supplement for TF and NH to
formulate the hybrid versions of the feeds. The Estimated Marginal Mean (EMM) was estimated to examine the
average response of each factor. The analysis of variance revealed there is significant difference in the weight
gain due to the effect of the feed formulations with Pvalue of 0.000. The Post Hoc analysis with Duncan
Multiple Range test (DMRT) for multiple comparison to determine homogeneous subsets revealed that the
granulated maize (0.2412) has the least effect while NH (mean=1.0346) and TF (mean=0.9150) outperformed
their hybrid version MNH (1.0019) and MTF (0.5237) indicating the tendency of reduction in the effect of the feed as a result of the granulated maize mixed as supplement. The hybrid MNH and granulated maize were considered as homogeneous subsets based on the test of multiple comparisons
Influence Des Techniques Culturales Simplifiées Superficielles Sur La Productivité Du Niébé (Vigna Unguiculata (L.) Walp) Cultivé Au Burkina Faso
Authors: Kaboré Zeya , Gagré Charles , Zombré Et Gérard
Published: January 2025

Résumé
Contexte : Le niébé (Vigna unguiculata (L.) Walp) est une espèce herbacée tropicale appartenant à la famille des
Fabacées. Il regorge de valeurs nutritionnelles importantes et constitue la principale source de protéines pour la
population consommatrice. Au Burkina Faso, la production du niébé peine à couvrir le besoin national à cause
des faibles rendements liés aux méthodes de culture inadaptées.
Matériel et méthodes : Dans l’optique d’améliorer le rendement de cette culture, un essai permettant d’étudier
l’influence des différentes techniques culturales sur les paramètres morphologiques et agronomiques du niébé, a
été installé à Tenkodogo dans la région du Centre-Est du Burkina Faso. Le travail superficiel du sol (TSS), le
semis direct (SD) et le labour ont été les différents traitements utilisés dans un dispositif en bloc de Fisher
complètement randomisé avec 4 répétitions. Les paramètres morphologiques tels que le nombre de feuilles, la
hauteur de la plante, le diamètre au collet et le nombre de ramifications ont été observés. Des paramètres
physiologiques et agronomiques ont également été mesurés.
Résultats : Aucune différence significative n’a été observée entre les traitements sur les paramètres
morphologiques et physiologiques à l’exception du nombre de feuilles. L’observation portée sur les paramètres
agronomiques a montré des différences significatives et très hautement significatives entre le labour, le TSS et le
SD. Les meilleures performances agronomiques ont été enregistrées sous le TSS avec un rendement grain de
1027,08 kg/ha. Pour les plantes des parcelles sous SD, le rendement grain estimé est de 826,66 kg/ha et celui des
plantes des parcelles labourées s’estime à 735,41kg/ha.
Conclusion : Le travail superficiel du sol doit donc être adopté par les producteurs en vue d’accroitre le rendement des cultures en général et du niébé en particulier, tout en conservant le sol. Mots clés : agronomiques, morphologiques, labour, paramètres, rendement
A Evolução E O Impacto Dos Operadores Logísticos Na Cadeia De Suprimentos
Authors: Amorim Apolo Simões , Cunha Rillary Lopes , Simonetti Gabriele Roberto , Maduro Márcia Ribeiro , Filho Wlademir Leite Correia
Published: January 2025

Os operadores logísticos desempenham um papel fundamental na cadeia de suprimentos moderna, fornecendo
uma ampla gama de serviços especializados, como transporte, armazenagem, gestão de estoques e distribuição
física. Este artigo apresenta uma análise detalhada do conceito de operador logístico, sua evolução histórica e
sua relevância em diferentes setores, como o varejo e a logística portuária. A pesquisa destaca as diferentes
classificações de operadores logísticos, incluindo 1PLs, 2PLs, 3PLs, 4PLs e 5PLs, cada qual com funções
específicas na gestão da cadeia de suprimentos. Também se discute o aumento da demanda por operadores
logísticos no setor varejista, impulsionada especialmente pela expansão do comércio eletrônico. Além disso, o
estudo aborda os critérios essenciais para a decisão de contratar um operador logístico, considerando tanto a
perspectiva dos clientes quanto das empresas contratantes. Aspectos como eficiência operacional, adoção de
tecnologias, sustentabilidade e gestão de riscos são identificados como fatores críticos e oportunidades
relevantes para futuras pesquisas no campo da logística. Assim, este estudo fornece uma visão abrangente sobre o papel dos operadores logísticos na cadeia de suprimentos, ressaltando sua importância para a economia global e apontando áreas estratégicas para o desenvolvimento e a inovação no setor
Nifactor Influencing The Customer Reviews On Purchase Intention Of Consumer Electronic Goods
Authors: Jenilah A. Dalsy Sheebha , V.Satchithanantham Dr. , Sivakumar Dr.R.
Published: January 2025

Purpose: The study investigates the impact of online reviews and ratings on the purchase intentions of
consumers in the electronic goods. Research methodology: The study is conducted in Villupuram district,
Tamil Nadu, covering both urban and rural areas. Research Area: Villupuram district consists of 9 taluks, 928
villages, 2 municipalities, 8 town panchayats, and 688 village panchayats. The focus area includes Villupuram
college students who are buying goods from Online capturing a diverse demographic profile. Sample Size: A
total of 2,635 students and teachers participated in the study. Among them, 413 respondents were identified as online customers. Sampling Technique: A purposive sampling method was employed to select respondents who actively participate in online shopping. Finding:
Data-Driven Culture Maturity Assessment: In Which Aspects Does The Use Of Data Technologies Impact Companies In The Current Brazilian Scenario
Authors: Mangini Douglas Da Silva , Freitas Renan Melo De , Emeagwali Kosisochukwu Annabelle , Pierro Alexandre Riberti Di , Lins Romulo Gonçalves
Published: January 2025

Well-structured and available data is one of the most valuable goods for companies. This study aims to understand
and evaluate the reality of the Brazilian Market in the Data-Driven Culture scenario in terms of the most evident
current data trends, such as Business Intelligence, Big Data, Cloud Computing, and Machine Learning. The
proposed methodology is based on a questionnaire regarding data-driven culture adherence to strategic
decisions, data tools, and governance and control. The two-stage analysis aims to extract the reality and how the
use of data technologies may be able to differentiate them competitively. As a result, it is possible to deduce that
the sample of the Brazilian Market shows high similarities of Maturity-Digital with an average to a high score
for all the analyzed individual aspects and contains the statistical approach showed that for the sample that the
Digital Maturity is strongly associated with the financial results and Internal Approval of Employees. On the other hand, the results were not conclusive for Brand Recognition and Customer Approval and were weakly associated with Operational Efficiency
Desafios E Perpetuidade Da Prática Da Quebra Do Coco Babaçu: Uma Análise Das Quebradeiras De Coco Da Comunidade Zumbi, Em Timon/Maranhão A Partir Dos ODS Da ONU
Authors: Neto Raimundo Beserra Da Silva , Feitosa Aryadynna Santos , Menezes Domingos Albano Matos De , Sousa Elisângela Alves De , Bueno José Luís De Carvalho
Published: January 2025

Antecedentes: O artigo, apresenta uma pesquisa de campo realizada com as quebradeiras de coco da
comunidade Zumbi, localizada a 18 km de Timon, Maranhão. O estudo abordou as experiências de 20 mulheres
que mantêm viva a tradição da quebra do coco babaçu e enfrentam desafios para a perpetuidade da prática. A
pesquisa, alinhada com os Objetivos de Desenvolvimento Sustentável (ODS) das Nações Unidas, aborda aspectos
culturais, econômicos e ambientais da prática, bem como o potencial turístico da região. O Objetivo do estudo
sustenta-se em explorar os desafios enfrentados pelas quebradeiras de coco babaçu da comunidade Zumbi em
Timon/MA e analisar como a prática pode contribuir para o desenvolvimento sustentável da região, promovendo
o ODS 8 (Trabalho Decente e Crescimento Econômico) e o ODS 15 (Vida Terrestre). A pesquisa justifica-se por
analisar as implicações sociais, econômicas e culturais que a prática da quebra do coco babaçu promove no
Maranhão.
Metodologia: O estudo utilizou uma abordagem qualitativa para explorar as percepções das quebradeiras de
coco babaçu da comunidade Zumbi, em Timon, Maranhão. Baseado em pesquisa de campo com observação
participante e entrevistas semiestruturadas, envolveu 20 mulheres selecionadas por amostragem intencional para
captar diversidade de experiências. Os dados foram analisados por técnica de análise de conteúdo, identificando
temas como desafios econômicos e sustentabilidade ambiental. Triangulação de dados e devolutiva às
participantes garantiram a validade dos resultados. O estudo seguiu rigorosos aspectos éticos, incluindo
consentimento livre e esclarecido.
Resultados: As quebradeiras de coco babaçu da comunidade Zumbi enfrentam condições de trabalho precárias,
com dependência econômica de atravessadores e falta de políticas públicas para formalização e apoio. Apesar
disso, suas práticas sustentáveis reforçam a importância dos ODS 8 e 15, promovendo a biodiversidade e
sustentabilidade ambiental. O turismo sustentável surge como uma oportunidade para valorizar a atividade, mas
desafios como desvalorização social, riscos ambientais e falta de políticas adequadas ameaçam sua continuidade.
A transmissão de saberes entre gerações e o fortalecimento da equidade de gênero são cruciais para perpetuar
essa tradição cultural e econômica.
Conclusão: A prática da quebra do coco babaçu na comunidade Zumbi, em Timon, é uma expressão de autonomia
e preservação cultural, resistindo às pressões da modernização. Para garantir sua continuidade, são necessárias
políticas públicas que promovam capacitação, turismo sustentável e parcerias estratégicas. Com apoio
adequado, a tradição pode se tornar um modelo de desenvolvimento sustentável, unindo inclusão social, preservação ambiental e fortalecimento econômico.
An Analysis Of Solid Waste Management At A Civil Construction In The City Of Manaus-Am.
Authors: Bezerra Eliane Sigrid Lacerda Dos Reis , Campos Paola Souto , Alencar David Barbosa De , Bezerra Antônio Lapa , Bezerra Carlos Gabriel Dos Reis
Published: January 2025

Background: The increase in the generation of solid waste worldwide is the result of growing urbanization and
industrialization, and construction stands out as one of the main sources of waste, generating a substantial
amount of rubble and discarded materials. This study proposes an analysis of solid construction waste
management at a construction site in the city of Manaus.
Materials and Methods: An exploratory study was carried out in the field, through observational analysis of the
construction process. This research is descriptive, as it describes the particularities and facts of the company,
and exploratory, as it identifies the waste generated and draws up a manual of good practices.
Results: The company does not have an official construction waste management plan, but it is looking for
integrated solutions, where the destination of construction waste can be recycling or reuse on the construction
site itself. The company has adopted strategic guidelines aimed at sustainable development. The company is on the lookout for innovative solutions to improve its processes, especially those linked to construction methods, with a view to more sustainable management of the entire business.
Exploring The Paths To Employee Performance: The Role Of Job Satisfaction As A Mediator On Human Resource Quality, Leadership, And Discipline At PT Syar Garansi Nasional
Authors: Saptono Langgeng , . Handriyono , Awwaliyah Intan Nurul
Published: January 2025

This research seeks to assess the correlations between Human Resource Quality (X1), Leadership (X2),
Discipline (X3), Job Satisfaction (Z), and Employee Performance (Y) at PT Syar Garansi Nasional using a
quantitative approach through survey methods. This study examine the direct and indirect effects of HR quality,
leadership, and discipline on employee performance, utilizing work satisfaction as a mediating variable. The
research employs Partial Least Square (PLS) analysis is a multivariate statistical technique comparing multiple
dependent and independent variables. The results indicate that Human Resource Quality does not have a
significant effect on work satisfaction or employee performance. Same result at Leadership variable and
Discipline variable do not directly effects employee performance. Leadership and discipline significantly
influence job satisfaction, which, in turn, markedly affects employee performance. About the mediation role, job
satisfaction does not significantly mediate the association between HR quality and employee performance.
Conversely, it substantially mediates the links between Leadership and employee performance, as well as
Discipline and employee performance. The results underscore the essential function of job satisfaction as an intermediary variable, indicating that PT Syar Garansi Nasional should emphasize initiatives to augment job happiness to increase overall employee performance.
Cultura Digital E Aprendizado: Como As Redes Sociais Podem Ser Aliadas No Ensino?
Authors: Júnior Antônio Carlos Pereira , Nozawa Isadora Aparecida , Ferreira Rafael Paulino , Campos Michelle Rojo , Zandoná Clara Damasceno
Published: January 2025

Background: As redes sociais destacam-se como ferramentas educacionais ao estimular criatividade,
engajamento e aprendizado colaborativo. Este estudo analisa como essas plataformas podem enriquecer o
ensino e a aprendizagem, enfrentando desafios como privacidade, desigualdade e formação docente. Os
resultados mostram que, usadas estrategicamente, podem integrar aprendizado formal e informal, promovendo
colaboração global e criatividade, desde que apoiadas por políticas inclusivas e formação docente qualificada.
Materials and Methods: Este estudo utiliza uma abordagem qualitativa baseada em revisão bibliográfica e
análise de casos sobre o uso de redes sociais na educação. Foram examinados artigos acadêmicos, políticas
públicas e práticas envolvendo plataformas como Facebook, Twitter e YouTube. A análise abordou três
aspectos principais: (1) estímulo à criatividade e engajamento; (2) integração entre aprendizado formal e
informal; e (3) desafios na implementação educacional. Os dados foram organizados para identificar
estratégias eficazes e intervenções políticas relevantes.
Results: A análise revelou que as redes sociais, quando integradas estrategicamente, podem enriquecer as
experiências educacionais ao promover criatividade, engajamento e aprendizado colaborativo. Elas têm o
potencial de integrar aprendizado formal e informal, incentivando a interação entre os alunos além dos limites
da sala de aula. No entanto, desafios como preocupações com privacidade, desigualdade de acesso e falta de
formação docente adequada continuam a limitar seu impacto. Os resultados destacam a necessidade de
políticas públicas robustas e abordagens pedagógicas éticas para superar essas barreiras e maximizar os
benefícios das redes sociais no ensino.
Conclusion: As redes sociais, quando estrategicamente utilizadas, podem transformar a educação ao estimular
criatividade, engajamento e aprendizado colaborativo. Contudo, para maximizar esses benefícios, é crucial superar desafios como privacidade, desigualdade e formação docente. Políticas públicas eficazes e práticas pedagógicas inovadoras são fundamentais para aproveitar plenamente seu potencial educacional
O Papel Da Educação A Distância No Brasil: Entre Tecnologias E Práticas Presenciais
Authors: Valentim Rayane Emanuelle De Oliveira , Souza Lívia Barbosa Pacheco , Solha Davi Augusto Trevizan , Rosa Débora Da Silva , Torres Aldenira Teixeira Da Silva
Published: January 2025

Este artigo científico explora os desafios e possibilidades da educação a distância (EaD) no Brasil, com foco na
importância da qualificação contínua dos docentes e no comprometimento dos alunos que escolhem essa
modalidade de ensino. A partir do método de revisão bibliográfica, a pesquisa foi fundamentada em consultas a
bases de dados como SciELO, além de relatórios institucionais e documentos disponibilizados em sites
governamentais, como os do Ministério da Educação (MEC) e do Instituto Nacional de Estudos e Pesquisas
Educacionais Anísio Teixeira (INEP). O estudo evidencia que, apesar de sua contribuição para a
democratização do acesso ao ensino superior, especialmente em regiões afastadas, a EaD enfrenta desafios
significativos, como a necessidade de formação docente especializada para o uso de tecnologias educacionais e
para o desenvolvimento de estratégias pedagógicas inovadoras. Também se destaca a importância de estimular
o engajamento e a autonomia dos estudantes, fatores cruciais para a redução da evasão e o sucesso acadêmico.
Outro aspecto abordado é a relevância das práticas presenciais e da educação híbrida, mesmo em cursos
predominantemente virtuais. A integração entre o virtual e o presencial contribui para uma formação
profissional mais completa, promovendo o desenvolvimento de competências práticas e habilidades
socioemocionais altamente valorizadas pelo mercado de trabalho. Os dados analisados mostram que estudantes
de modelos híbridos apresentam maiores índices de empregabilidade e melhores perspectivas salariais. Assim, o artigo reforça a necessidade de avanços na estrutura e nas metodologias da EaD para fortalecer seu papel como modalidade de ensino de qualidade e inclusão social.
Tecnologias Na Educação E Suas Implicações Para O Desempenho Escolar Dos Estudantes
Authors: Ferreira Rogério Dos Santos , Gutierrez Giuliana Loffredo , Santos Leandro Teles Antunes Dos , Moser Giancarlo , Sousa Gilson Pereira De
Published: January 2025

Esta pesquisa teve como objetivo analisar as implicações da integração das tecnologias na educação sobre o desempenho escolar dos estudantes, investigando tanto os benefícios quanto os desafios que surgem com o uso dessas ferramentas no ambiente educacional. Adotou-se uma abordagem exploratória, descritiva e qualitativa, com uma amostra composta por 25 profissionais da educação, incluindo professores, coordenadores pedagógicos e gestores escolares, que participaram de entrevistas semiestruturadas. Os resultados indicaram que, embora a
tecnologia tenha um impacto positivo no engajamento dos alunos e na compreensão de conteúdos, a desigualdade
no acesso a dispositivos e à internet, bem como a falta de capacitação contínua para os educadores, limitam seu
potencial. Além disso, a resistência de alguns professores ao uso de tecnologias foi um obstáculo para a
transformação educacional. Conclui-se que, para otimizar os resultados da integração tecnológica, é necessário
investir em formação profissional contínua, melhorar a infraestrutura escolar e garantir o acesso equitativo às ferramentas digitais, adaptando metodologias pedagógicas para que a tecnologia se torne um recurso eficaz no processo de ensino-aprendizagem
Women, Peace, And Security: Progress And Challenges In Global Leadership And Policy
Authors: . .
Published: January 2025

The inclusion of women in peacebuilding, leadership, and security frameworks has been a significant focus of
international policy since the adoption of United Nations Security Council Resolutions (UNSCR) 1325 (2000)
and 1820 (2008). These resolutions marked a turning point by recognizing women’s critical role in conflict
resolution and the prevention of sexual violence as a weapon of war. However, significant challenges remain.
Women continue to face systemic exclusion from leadership roles, marginalization in peace negotiations, and
persistent violence that undermines their agency and rights.
This article examines five key areas critical to advancing the Women, Peace, and Security (WPS) agenda: (1)
women’s participation in peace processes, (2) ending impunity for violence against women (VAW), (3) prevention
through empowerment, (4) intersectionality and inclusion, and (5) data-driven policies and accountability. Realworld examples, such as the UNITE to End Violence Against Women campaign, India’s Bell Bajao initiative, and
the Generation Equality Forum (2021), demonstrate both the progress achieved and the gaps that persist. The
findings underscore the need for a holistic, intersectional, and inclusive approach to gender equality that
combines grassroots activism with sustained international commitments.
By addressing structural barriers and fostering accountability, women’s leadership can drive sustainable peace and security worldwide. Achieving gender parity in peacebuilding is not merely a moral imperative but a strategic necessity for achieving inclusive, long-term development
The Retention Of Researchers In Brazilian Regions
Authors: Cavalcante Igor Barros , Lima Damísia , Almeida Alexandre Nascimento De , Junior Celso Vila Nova De Souza , Delgrossi Mauro Eduardo
Published: January 2025

Background: Regional development policies in Brazil date back to the 1950s, particularly after World War II,
and encompass scientific and technological issues. Institutions like CNPq and CAPES were established to
promote science and technology. Despite these efforts, the effectiveness of these policies in retaining highly
qualified researchers in underdeveloped regions remains uncertain, necessitating further evaluation.
Hypotheses and Methods: This study investigates whether postdoctoral fellowships provided by CNPq
contribute to the retention of doctoral researchers in Brazil, with a specific focus on the North, Northeast, and
Midwest regions. Four hypotheses were formulated: the existence of researcher mobility, the prevalence of
researcher retention in regions of national interest, the impact of government incentives on retention, and the
overall contribution of CNPq fellowships to national retention. Data from the Lattes and Fomento Panels were
analyzed, utilizing multiple regression and logistic regression methods to assess relationships between
researcher retention, location, and fellowship status.
Results: The findings indicate significant mobility among researchers, with negative mobility noted in the South
and Southeast and positive mobility in the North and Midwest. While postdoctoral fellowships positively
influence retention in regions of interest, non-fellow researchers show even higher retention rates. Additionally,
receiving a CNPq fellowship is associated with a lower likelihood of researchers staying in Brazil, suggesting
that other factors beyond government incentives may play a more decisive role in researcher retention. Conclusion: CNPq postdoctoral fellowships do not consistently or significantly contribute to the retention of researchers in Brazil
Paired related homeobox 1 attenuates autophagy via acetyl‐CoA carboxylase 1‐regulated fatty acid metabolism in salivary adenoid cystic carcinoma
Authors: Gao Jie , Ma Kangjie , Zhang Li , Li Tao , Zhao Baodong , Jiang Yaping
Published: January 2022

Autophagy can affect the invasion and metastasis of carcinoma. Our previous study has shown that invasion and epithelial‐mesenchymal transition in salivary adenoid cystic carcinoma (SACC) can be promoted by the metabolic reprogramming of free fatty acids (FFAs). However, the effect of FFA metabolism on autophagy in SACC remains unknown. In this study, we showed that overexpression of paired related homeobox 1 (PRRX1) reduced the number of autophagosomes and decreased the expression of LC3 and Beclin‐1 in SACC patients and SACC‐83 cells in vitro. Moreover, PRRX1‐mediating FFA reprogramming triggered to autophagy via regulating acetyl‐CoA carboxylase 1 (ACC1), leading to invasion and migration in SACC.
AJP issue focuses on cannabis, alcohol and psychosis links
Authors: Knopf Alison
Published: January 2022

The current issue of the American Journal of Psychiatry focuses on the interactions between alcohol use, cannabis use, substance use disorders (SUDs) and other psychiatric illnesses.
Deaths from drinking up in the U.K.
Authors: Knopf Alison
Published: January 2022

According to a recent report from the Office for National Statistics (ONS), deaths from alcohol‐specific causes in the United Kingdom have increased from 11.8 per 100,000 people in 2019 to 14 per 100,000 people in 2020.
Recent Advances on Dual‐Band Electrochromic Materials and Devices
Authors: Zhai Yanling , Li Jiahui , Shen Sophia , Zhu Zhijun , Mao Sui , Xiao Xiao , Zhu Chengzhou , Tang Jianguo , Lu Xiaoquan , Chen Jun
Published: January 2022

Dual‐band electrochromism is a phenomenon where materials can independently regulate the transmittance of visible (VIS) and near‐infrared (NIR) light. Owing to their bistability, low energy consumption, and independent control over VIS and NIR regions, dual‐band electrochromic (EC) devices have been of great significance to fully harnessing VIS and NIR light and building an energy‐saving society. The past several years have witnessed the efforts put in developing novel EC materials to improve their dual‐band optical performance through altering their composition, structural, and physicochemical features, which determine the optical behavior of dual‐band EC devices. In this review, the concept, significance, working principle, and key influence factors of dual‐band electrochromism are briefly introduced. Next, the up‐to‐date progress of dual‐band EC materials including inorganic, organic, and composites materials are summarized, with a focus on material design, device fabrication, and performance optimization. Finally, the challenges and perspectives of dual‐band EC materials and devices are also presented.
In Situ Generation of Gold Nanoparticles on Bacteria‐Derived Magnetosomes for Imaging‐Guided Starving/Chemodynamic/Photothermal Synergistic Therapy against Cancer
Authors: Ye Peng , Li Feng , Zou Jiale , Luo Ying , Wang Shuang , Lu Guihong , Zhang Fan , Chen Chang , Long Jiaxin , Jia Rongrong , Shi Min , Wang Yugang , Cheng Xiyu , Ma Guanghui , Wei Wei
Published: January 2022

There are several attractive opportunities for using magnetic nanomaterials for anticancer applications. Herein, a magnetic nanomaterial platform is successfully developed based on natural Fe3O4 magnetosomes extracted from the bacterium Magnetospirillum magneticum AMB‐1 for anticancer therapy. The authors initially functionalize the magnetosome membranes in situ with gold nanoparticles to construct an attractive core‐satellite structure. Subsequently, the physical properties and application potentials of these structures are characterized as contrast agents for photoacoustic imaging and magnetic resonance imaging and as therapeutic agents with selective magnetic field guidance for diverse antitumor modalities, including starving, chemodynamic, and photothermal therapies. Owing to the high‐performance imaging‐guided synergistic effect, only a single injection and single laser irradiation result in excellent therapeutic efficacy against tumor growth in multiple cell‐derived xenograft tumor models and, most notably, patient‐derived organoid and patient‐derived xenograft tumor models. The demonstrations of the use of natural magnetic nanomaterials to achieve strong and synergistic antitumor performances highlight the promising application potential of this flexible and easy‐to‐prepare platform for developing innovative treatments for diseases in humans.
Multifunctional MoTe2 Fe‐FET Enabled by Ferroelectric Polarization‐Assisted Charge Trapping
Authors: Gao Jing , Lian Xu , Chen Zhixian , Shi Shu , Li Enlong , Wang Yanan , Jin Tengyu , Chen Huipeng , Liu Lei , Chen Jingsheng , Zhu Yao , Chen Wei
Published: January 2022

The “Internet‐of‐Things”‐based information society requires the devices to possess high scaling capability as well as rich functionalities. Hybrid systems coupling 2D semiconductors and functional ferroelectrics are attracting increasing attention as complementary devices to the existing silicon systems due to their outstanding electronic and optoelectronic performances. In this work, interfacial states are introduced on the ferroelectric Hf0.5Zr0.5O2 thin film during the annealing process. Utilizing the synergetic effect of ferroelectric polarization and charge trapping behavior, a multifunctional 2D Fe‐FET is demonstrated, exhibiting reliable memory properties, tunable synaptic functions, and reconfigurable photodetection behaviors in one single device. Among them, multiple storage levels are achieved with a long retention time. Flexible plasticity including short‐term plasticity (STP)/long‐term plasticity (LTP) is emulated successfully, and the excellent emulated synaptic behaviors also contribute to the pattern recognition accuracy of ≈81% in artificial neural network simulations. Furthermore, the ferroelectric polarization‐dependent optoelectronic response is observed, making it promising for the optoelectronic logic device application. The results pave the way for the fabrication of high‐density data process systems with various functions.