Analysis on the effect of CGF scaffold material combined with pulpotomy in the treatment of caries-derived pulpitis and the value of coronal pulp regeneration
Authors: Wang Feifei , Hou Xiaowei , Fan Shifeng , Zheng Yu , Liu Jing , Gong Sufen , Gu Weiwei 
Published: September 2023

Objective: To investigate the clinical effect of concentrated growth factor scaffold combined with pulpotomy in the treatment of caries-derived pulpitis. Methods: In this study, 120 patients with caries-derived pulpitis treated in our hospital from June 2021 to June 2022
were selected for retrospective analysis. Among them, 60 patients were treated with pulpotomy plus concentrated growth factor material scaffold plus root repair material (IROOT) material coverage (research group), another 60 patients were selected for pulpotomy treatment plus IROOT material
coverage (control group), and the pain degree, periodontal gingival index, inflammatory factors in gingival crevicular fluid, dentin thickness, and treatment success rate were compared between the two groups before and after treatment. Results: The pain degree of the two groups before
and after treatment was evaluated and compared, and there was no significant difference in the baseline visual analogue pain scale score between the research group and the control group before treatment (P >0.05); the pain degree of the patients was significantly relieved, and the
VAS scores of the patients in the study group were lower than those in the control group, and the difference was statistically significant (P <0.05); there was no significant difference in the levels of substance P , IL-8 and MMP-8 in gingival crevicular fluid between the two groups
before treatment (P >0.05); the above indicators were detected again after 7 days of treatment, the substance P and IL-8 in the gingival crevicular fluid of the research group were lower than those of the control group, and the differences were statistically significant (P
<0.05); there was no significant difference in the probing depth of periodontal pocket, probing bleeding index, gingival index, and plaque index between the research group and the control group before treatment (P >0.05); after 7 days of treatment the above indicators were tested
again, and the probing depth of periodontal pockets, probing bleeding index, and gingival index in the research group were lower than those in the control group, and the differences were statistically significant (P <0.05); the treatment success rate of the group was 98.33% higher
than that of the control group, which was 85.00%, and the difference was statistically significant (P <0.05); before treatment, there was no significant difference in the dentin thickness between the study group and the control group (P >0.05); while dentin thickness was
measured again after 3 months and 6 months of treatment, and the difference between the research group and the control group was not statistically significant (P >0.05). Conclusion: concentrated growth factor stent combined with pulpotomy in the treatment of caries-derived
pulpitis can better relieve pain, reduce the degree of inflammatory response, improve periodontal health indicators, and improve the success rate of treatment.