bluuebunny/crossref_metadata_2025 huggingface dataset:
Faktor determinan risiko kardiometabolik pada remaja usia 15-18 tahun
Authors: Wiboworini Budiyanti , Shabrina Amalina , Dewi Yulia Lanti Retno , Sari Amelya Augusthina Ayu , Handayani Sutartinah Sri , Damayanti Kusmadewi Eka , Azzahrah Aisyah , Tjung Vivienne
Published: January 2025

Determinant factors of cardiometabolic risk in adolescents aged 15-18 yearsBackground: Cardiometabolic diseases are increasing worldwide, and the risk of developing them starts as early as adolescence. In the long term, they may lead to comorbidities. Evidence suggests the risk factors of cardiometabolic diseases among adolescents are obesity, excessive food intake, socioeconomic status, breakfast habits, and physical activity, among others. Objective: This study aimed to determine the determinants of cardiometabolic risk in adolescents aged 15-18. Methods: This was a cross-sectional study in Al-Abidin High School Surakarta with 146 study subjects. Cardiometabolic risks were classified using Cardiometabolic Disease Staging (CMDS), waist circumference was measured with Medline, physical activity was measured using a Physical Activity Questionnaire for Adolescents (PAQA), and blood pressure was measured with a sphygmomanometer. Socioeconomic, transportation, and breakfast habits were obtained from the general questionnaire. Chi-square, ANOVA, and logistic regression were then performed using SPSS 23. Results: Gender was significantly associated with cardiometabolic risk (p=0.001). A total of 41.3% of boys were at risk of cardiometabolic (OR=3.964). Socioeconomic, breakfast habits, transportation, and physical activity were not associated with cardiometabolic risk (p>0.05).Conclusion: Boys 15 – 18 years were at a higher risk of cardiometabolic, by 3.694 times greater than girls. Socioeconomic status, breakfast habits, transportation, and physical activity were not correlated with cardiometabolic risk among adolescents.
Perbedaan asupan zat gizi, pengetahuan anemia, dan kepatuhan konsumsi Tablet Tambah Darah (TTD) pada remaja putri di pesantren dan nonpesantren
Authors: Alfianti Esya Aqilla , Dieny Fillah Fithra , Kurniawati Dewi Marfu’ah , Wijayanti Hartanti Sandi
Published: January 2025

Differences in nutrient intake, anemia knowledge, and adherence to blood supplement tablet consumption between adolescent girls in Islamic boarding schools and non-Islamic boarding schoolsBackground: Anemia is a nutritional problem that often occurs in adolescent girls, especially in Islamic boarding schools, where the prevalence of anemia in adolescent girls reaches >40%. Factors causing anemia in adolescent girls include a lack of iron, protein, and folate intake, low knowledge of anemia, and a lack of consumption of blood supplement tablets.Objective: This study aimed to analyze the differences in nutrient intake, knowledge of anemia, and adherence to blood supplement tablet consumption between adolescent girls in boarding schools and non-boarding schools.Methods: This study was observational-analytic with a cross-sectional design. The subjects were 24 adolescent girls at PP Al-Uswah (an Islamic boarding school group) and 24 at SMAN 12 Semarang (a non-Islamic boarding school group). The study variables were nutrient intake, anemia knowledge, and adherence to blood supplement tablets. Statistical analysis used an independent sample t-test of normally distributed and a Mann-Whitney test if not normally distributed.Results: There were significant differences in the knowledge of anemia (p<0.001) and protein intake (p = 0.003) from both groups. The non-boarding school group had higher anemia knowledge and protein intake than the boarding school group. Iron intake, folate intake, and adherence to blood supplement tablet consumption in both groups showed no significant difference (p > 0.005).Conclusions: Adolescent girls in boarding and non-boarding schools significantly differed in protein intake and knowledge of anemia. There was no significant difference in adherence to blood supplement tablet consumption between them.
Research on the Innovation of the Employment Assistance Mechanism Relying on School-Enterprise Cooperation in Private Colleges and Universities in the New Era
Authors: Wang Qiuxiang , Wang Fuli , Ji Haiying
Published: January 2025

This paper focuses on the practical employment problems of students in private colleges and universities, actively explores new paths for employment assistance, and studies the specific practices of establishing industry studios with the help of school-enterprise cooperation. The aim of this research is to deeply integrate enterprise resources and the talent cultivation system of universities, build a practical and communication platform for students that is in line with the actual situation of the industry, help improve students’ employment competitiveness, further open up a new situation for employment assistance in private colleges and universities, and enhance the quality of talent cultivation and employment.
AI-Driven Telemedicine: Bridging Healthcare and Technology for the Future
Authors: B S Jothi Prakash
Published: January 2025

Telemedicine and Artificial Intelligence (AI) are breaking through the established barriers of healthcare delivery
systems all over the world. This paper studies the multiple ways in which AI can make remote healthcare delivery faster, more
personalized, and more accessible, such as developing better diagnostics and personalized treatment pathways. Contrary to
simply being about automation, telemedicine reminds one that AI keeps changing by data from patients. The new architecture of
AI, its cases of disruption, and the future forecast have also been included in the paper. It has also discussed some of the critical
ethical issues and infrastructural barriers that can control the intelligent deployment of healthcare systems.
Investment Patterns of Salaried Individuals: A Study of Tax Planning Practices in Bengaluru City
Authors: C Mr. Chittibabu
Published: January 2025

This study explores the investment patterns of salaried individuals in Bengaluru City with a focus on their tax
planning practices. Tax planning, a critical component of financial management, not only reduces tax burdens but also
influences investment decisions. The research aims to understand how salaried professionals utilize tax-saving instruments
prescribed by Indian tax laws, including deductions, exemptions, and tax-linked investment schemes, and how these practices
shape their overall investment behavior. The analysis is based on data gathered from 100 salaried individuals across diverse
professional and income groups. Statistical tools, including Chi-square tests, ANOVA, and the Friedman test, are applied to
examine the relationship between tax planning awareness and investment preferences.
The findings indicate a strong preference for basic tax-saving options such as Section 80C investments, while awareness and
utilization of advanced tax planning strategies remain limited. This knowledge gap restricts the optimization of tax-efficient
investment opportunities. The study concludes that tax planning significantly impacts investment patterns but highlights the
need for improved financial literacy and personalized advisory services to help salaried individuals make more informed
investment decisions that maximize both tax savings and financial growth.
Environmentally Responsible Behavior: The Roles of Personal Norms, Perceived Value, and Destination Social Responsibility
Authors: Ginting Ginta , Dewi Ike Janita , Maesaroh Imas
Published: January 2025

Objective: The objective of the study is to analyze the factors that shape tourists' environmentally responsible behavior. The proposed research model integrates norm activation theory, stakeholder theory, and a utilitarian perspective. From the norm activation theory perspective, two variables, namely awareness of consequences and ascribed responsibility, are included in the model as antecedents of personal norms. Destination social responsibility, as a stakeholder effort to promote environmental protection, can strengthen the influence of personal norms on environmentally responsible behavior. Furthermore, the utilitarian perspective in the form of perceived value, which is the benefit that tourists obtain from traveling to a destination, is also a moderating influence of personal norms on environmentally responsible behavior. Methodology: This study involved 255 respondents who had visited Yogyakarta. Data were processed using Smart-PLS to determine the relationships between variables. Finding: The results show that awareness of consequences and ascribed responsibility are factors in forming personal norms. Personal norms have a positive influence on environmentally responsible behavior. Furthermore, the data supported the role of perceived value as a moderator. However, destination social responsibility does not moderate the influence of personal norms on environmentally responsible behavior. Conclusion: The study concludes that the norms activation theory holds that personal norms are antecedents to environmentally responsible behavior. Personal norms’s influence on environmentally responsible behavior is strengthened by perceived value.
Moderating of Inflation Policy and Its Relation to the Effect of Interest Rate and Exchange Rate on Decreasing IHSG
Authors: Subhan Nuruddin
Published: January 2025

Objectives: The objectives of this research are: 1) to determine the effect of interest rates on the IHSG; 2) to determine the effect of the exchange rate on the IHSG; 3) to know the effect of the interest rate on the IHSG with inflation as moderation; and 4) knowing the effect of the exchange rate on the IHSG with inflation as moderation. Methodology: This research methodology was carried out using a quantitative model with a moderating effect analysis method which was processed using SmartPLS 3.0. The research findings and conclusions show that the significance value of interest rates is 0.747>0.05, which means that interest rates do not influence the IHSG. This means that interest rate movements during 2017-2022 are stable so that it does not cause investors to withdraw shares which has an impact on weakening the IHSG. Furthermore, the significance value of the exchange rate is 0.010<0.05, which means that there is an influence of the exchange rate on the IHSG. This is caused by the instability of the exchange rate in Indonesia during 2017-2022, because an increase in the exchange rate means that dividends distributed will decrease and investors will withdraw their shares, resulting in a weakening of the IHSG. Finding: The moderation of inflation on the effect of interest rates on the IHSG obtained a significance value of 0.000<0.05. Likewise, the moderation of inflation on the impact of the exchange rate on the IHSG obtained a significance value of 0.000<0.05. Conclusion: Inflation significantly moderates the influence of the interest rate and the exchange rate on the IHSG
Mediation of Organisational Commitment Empirical Study of Transformational Leadership, Job Satisfaction, and Perceived Organisational Support on Turnover Intention
Authors: Syaechurodji Syaechurodji , Haryadi Didit , Kania Dewi , Darmawan Dadan , Sanasa Yoke
Published: January 2025

Objectives: The phenomenon of turnover intention should be a concern for the company or organization owners. The phenomenon of turnover intention can be detrimental to the organization's survival. This study examines how the role of transformational leadership, job satisfaction, and perceived organizational influence turnover intention and how these roles modify organizational commitment.Methodology: This research uses quantitative research with a causality approach, with the Partial Least Squares Structural Equation Modeling (PLS-SEM) analysis method. The reason is that PLS-SEM can predict complex latent variables from a study. This research was conducted on J & T Cargo expedition employees in Tangerang Regency and a total sample of 131, testing the inner model and outer model and bootstrapping tests to test the mediation of organizational commitment.Finding: As formulated in the hypotheses, the results are consistent, where transformational leadership and employee job satisfaction significantly affect turnover intention, but perceived organizational support has no significant impact on turnover intention. Similarly, transformational leadership, job satisfaction, and perceived organizational support significantly impact organizational commitment. Thus, organizational commitment mediates the significant effect of transformational leadership, job satisfaction, and perceived organizational support on turnover intention. Theoretical and practical implications are presented.Conclusion: Organizations that emphasize developing transformational leadership qualities and prioritizing employee satisfaction will be better positioned to avoid turnover intention. By recognizing and acting on these insights, organizations can build positive employee engagement, retention, and success cycles. In summary, transformational leadership and job satisfaction significantly affect turnover intention, as satisfied employees are less likely to consider leaving their current organization.
Harmony of Nature: Building a Healthy Tourism Image Through Green Product Development
Authors: Setini Made , Putra Ida Bagus Udaya , Wahyuni Ni Made , Asih Daru , Triandini Evi
Published: January 2025

Objectives: Nowadays, village progress has also become a benchmark for the success of development in a country and region. The orientation of this study is to analyze the condition and potential of Subaya Village, Bangli, Kintamani, by using a mixed approach that combines field observation and SWOT analysis. The methodology applied involves in-depth observation of the village's strengths and weaknesses, as well as interviews with village officials and communities to identify opportunities and threats.Methodology: Applied using Analytical Hierarchical Process analysis involves in-depth observation of village strengths and weaknesses, as well as interviews with village officials and communities to identify opportunities and threats (SWOT-AHP). The main focus explored is to collect information from the local community and village officials regarding the potential of Subaya Village. Finding: This study shows that Subaya Village has significant strengths, such as abundant natural resources and rich local culture, which can be utilized for tourism development. However, there are weaknesses in infrastructure and limited human resources that need to be overcome. This research also identifies opportunities to develop ecotourism and community empowerment programs. Threats faced, such as climate change and competition from other regions, require appropriate mitigation strategies. Conclusion: Expected to provide a basis for the sustainable development of Subaya Village and improve community welfare through optimal utilization of local potential, and the utilization of the regional potential of Subaya Village through the development of tourism and ecotourism programs can enhance the welfare of the community while overcoming existing weaknesses and threats
The role of inter-project communication and continuous risk management strategy in a maintenance facility: A case study
Authors: Simon Daniel , Reicher Regina
Published: January 2025

The increasing complexity of modern aircraft maintenance and strict safety regulations of the sector underscore an emerging trend of implementing project management practices in maintenance, repair, and operations facilities (Junqueira, 2020; Freitas, 2020). This case study examines a German aircraft maintenance facility employing hybrid project management methodologies. It reveals how the lack of communication between parallel-running projects, combined with inadequate sustained risk management, results in unoptimized resource allocation, unforeseen disruptions, and considerable delays, thereby hindering project success. This research employs a case study approach, utilizing qualitative data gathered through semi-structured interviews and a six-week observation period. Analyzed through thematic coding and compared against an established theoretical project management framework, the findings underscore the significant impact of insufficient inter-project communication and risk management. The study highlights the necessity for a project management office (PMO) to harmonize parallel project executions, enhance inter-project communication, and ensure continuous risk management. Providing unique insights into the operations of a German maintenance, repair, and overhaul (MRO) facility, this research offers practical guidance for similar environments, contributing to the otherwise limited literature on project management in aircraft maintenance facilities.
Review of wind futures by Gaussian and Lévy jump risks
Authors: Dennhardt Benjamin , Lang Ling
Published: January 2025

Wind power futures, once a hedging tool in energy-related derivatives markets were discontinued due to low liquidity. However, recent increases in electricity price spreads have introduced new financing challenges for renewable energy projects in Europe, leading to heightened price risks and a renewed demand for such instruments. Also, the regulation on renewable electricity for renewable fuels of non-biological origin (RFNBO) — compliant hydrogen production poses a supply uncertainty risk to hydrogen developers. As both such project developers seek ways to mitigate these risks, this paper reviews the existing literature on modelling strategies for hedging wind power production risks. The review, based upon a structured literature review following vom Brocke et al. (2009), provides a comprehensive overview of arbitrage models incorporating seasonal elements and stochastic jump risks, as well as equilibrium pricing models. The variations and conclusions of these models are analyzed in the context of the altered market conditions in 2024. This analysis offers insights into the applicability of current models for pricing risk premia and identifies gaps under the evolving market realities.
The effect of three different acrylic intraocular lenses and capsulorhexis diameter on the posterior capsule opacification development
Authors: Todorovic Dusan , Sreckovic Suncica , Petrovic Nenad , Damjanovic Goran , Stamenkovic Miroslav , Srejovic Jovana , Cupic Katarina , Sarenac-Vulovic Tatjana
Published: January 2025

Introduction/Objective. Cataract represents a blur of the crystalline lens.
The only possible way of the cataract treatment is the surgical one. One of
the most common postoperative complications is the development of posterior
capsule opacification (PCO). The aim of this study was to exam the effect of
three different acrylic intraocular lenses (IOLs) and the capsulorhexis
diameter on the PCO development. Methods. The study included 92 patients
with a diagnosis of senile cataract divided into three groups according to
the IOL type. Every group was further divided into two subgroups depending
on capsulorhexis size. Posterior capsule opacification was measured 1, 6,
12, 18 and 24 months after the phacoemulsification. Results. The lowest PCO
24 months after phacoemulsication was measured in patients with three-piece
hydrophobic IOL (0.3 ? 0.08). Capsulorhexis diameter less than 5 mm had
statistically significant effect in patients with single-piece hydrophilic
(0.416 ? 0.187) and single-piece hydrophobic IOL (0.411 ? 0.082) during two
years follow-up. Conclusion. Posterior capsule opacification causes a
decrease of visual acuity and can be a reason for patients? dissatisfaction
in postoperative period. The only possible way for the treatment of
developed PCO is the usage of YAG laser capsulotomy, a procedure which can
be associated with serious complications. Thereby, the finest way for PCO
treatment is its prevention. The main role in that prevention has a choice
of adequate surgical technique and intraocular lens.
The impact of balneotherapy on IL-6 cytokine levels, disease activity, functional ability, fatigue and depression in patients with rheumatoid arthritis
Authors: Aleksic-Milenkovic Ivana , Stojanovic Sonja , Stamenkovic Bojana , Jevtovic-Stoimenov Tatjana , Saric Sandra , Dankovic Goran
Published: January 2025

Introduction/Objective. The aim of this study was to determine the impact
of balneotherapy on IL-6 cytokine levels, disease activity, functional
capacity, fatigue and depression in patients with rheumatoid arthritis.
Methods. The study included 46 patients with RA (16 with moderate, 16 with
low disease activity, and 14 in remission) who underwent BT as part of a
rheumatic disease treatment program, in the Niska Banja Institute, for a
duration of 3 weeks. BT was administered in the form of radon mineral baths
(lasting 15 to 20 minutes in the thermo-mineral waters of Niska Banja at a
temperature of up to 37?C). To evaluate the effect of BT, the study utilized
ELISA kits for measuring plasma cytokine IL-6 levels, DAS28 SE and CDAI for
assessing and calculating disease activity indices, the HAQ questionnaire
for measuring functional ability, the Beck Depression Inventory (BDI), and
the FACITF questionnaire for assessing fatigue. Results. Our research
results showed that the application of BT led to a statistically significant
improvement (p < 0.01, p < 0.001) in the values of all examined pa-rameters:
IL-6, DAS28 SE, CDAI, HAQ, FACITF, and BDI. Comparing the improvement in
these parameters among groups of patients with different disease activity
levels (moderate, low, remission), the most pronounced anti-inflammatory
effect of BT was observed in patients with moderate disease activity.
Conclusion. BT improved almost all observed parameters. Alongside
medication therapy, BT is a significant part of the comprehensive
therapeutic approach for RA patients.
Outbreak of white piedra in a flock of Extremeña blue hens
Authors: García Alfredo , Barraso Carmen
Published: January 2025

This paper describes for the first time a case of avian ringworm, caused by
Cutaneotrichosporon jirovecii in a small flock of Extreme?a blue hens and
highlights that the disease could occur in outbreak proportions, with 46.70%
of cocks affected. Infected birds had white crusts on the comb, and most
affected animals showed white or light brown nodules that were loosely
attached to the tip of feathers, but no systemic disease signs were
observed. The diagnosis of Trichosporon jirovecii was made by morphological
identification, and it was confirmed by sequencing amplification product of
the PCR using universal primers of the internal transcribed spacer region.
A Key Exchange Scheme Using Multicast Cryptography for InterSite Communication
Authors: T Sukegawa , S Akashi , T* Matsuzawa
Published: January 2025

In recent years, diverse work styles, such as satellite office work and remote work, have become widespread. In order to
securely and smoothly connect multiple sites, such as office and home or office and satellite office, it is important to construct
a network environment that can realize inter-site communication. At such sites, inter-site VPNs are used to achieve highly
reliable communication. We focused on VPNs between multiple sites, which have been studied as the number of sites increases.
For VPNs between multiple sites, Dynamic Multipoint VPN, which establishes a tunnel connecting multiple sites, and GET VPN,
which shares the same policy with a group, has been proposed. In this study, we proposed a method of sharing policies using
Multicast Cryptography. Multicast Cryptography is an encryption scheme that can be decrypted only by receivers selected by
the sender. The proposed method does not require a single key management server in the GET VPN, and the sender can share
the policy by selecting the receivers. Performance evaluation showed that the proposed method has the same establishment
time as existing IPsec implementations and is superior to existing methods when the number of sites increases. We also
discussed that the proposed method not only replaces existing multi-site communication, but is very useful for networks with
unbalanced privileges, since the sender can choose the receivers.
Contribution of Demographic Factors to Indonesia’s Economic Growth
Authors: Farah Alfa , Sugiyanto F.X.
Published: January 2025

Most empirical studies on the dynamics of Indonesia's economic growth predominantly adopt a Neoclassical framework. As the framework generally regards population growth as an impediment to economic growth, very few studies discuss the effect of demographic factors. Contributing to this limited literature, this study estimates the contribution of demographic factors to Indonesia’s economic growth. We employed a descriptive accounting framework to decompose the growth of GDP per capita into pure labor effect and productivity effect. The decomposition analysis shows that the contribution of demographic factors to GDP per capita growth generally declined during 1971–2020. From 1971 to 2000, the pure labor effect contributed more than the productivity effect. This was due to demographic transition and productivity enhancing labor reallocation. However, from 2000 to 2020, the pure labor effect's contribution fell below that of the productivity effect. The benefits of the growing dominance of working population been largely offset by reallocation of labor from high to low productivity sector and the decreasing rate in the labor force participation, leading to the decline in the relative contribution of pure labor effect.
Pre-operative moderate cognitive impairments and their importance in cognitive dysfunction development in post-coronary bypass patients
Authors: Trubnikova O. A. , Tarasova I. V. , Syrova I. D. , Kukhareva I. N. , Maleva O. V.
Published: January 2025

Aim. To determine the incidence and risk factors of postoperative cognitive dysfunction (POCD) after coronary bypass (CABG) in patients with pre-operative moderate cognitive impairment (MCI).

Materials and Methods. Up to CABG two groups were formed, consisting of 50 patients with presence and 51 without MCI. Neuropsychological research (12 tests) was conducted up to CABG, on the 10th day and after 1 year. Early (10 days after surgery) and remote (1 year later) POCD were diagnosed with a 20 % decrease in the rate of 20% of tests.

Results. Prior to CABG, they had a lower level of formation (p = 0.03), a lower fraction of the left ventricle ejection, (p = 0.02) and a more severe coronary tract lesion on the SYNTAX scale, (p = 0.01) than patients without MCI. Factors significant for the development of early POCD were the duration of with cardiopulmonary bypass (p = 0.035) and the severity of multi-organ insufficiency, rated on the SOFA scale (p = 0.04). In persons with pre-operative MCI, 72 % of cases were diagnosed with early POCD, 54 % with remote POCD, and 81 % with early POCD.

Conclusion. Chronic heart failure with low rates of left ventricular ejection fraction, severe coronary artery damage and low levels of education contribute to the development of MCI in patients with ischemic heart disease. Pre-operational MCI is not the main cause of POCD. However, its presence and development in these patients of early POCD contributes to its retention a year after surgery.
Epidemiological characteristics of mental disorders in the population of the Omsk region. A descriptive study (2010−2022)
Authors: Shirlina N. G. , Shirinskaya N. V. , Zhigalov Y. A. , Stasenko V. L.
Published: January 2025

Aim. Assessment of epidemiological manifestations of mental disorders in the Omsk region for the period 2010-2022.

Materials and methods. A retrospective epidemiological analysis of data from the federal statistical observation form No. 10 «Information on diseases with mental disorders and behavioral disorders (except for diseases related to the use of psychoactive substances)» for the Omsk region for 2010−2022 was carried out. The incidence rates (relative prevalence) of mental disorders per 100,000 population were calculated for the Omsk region as a whole and municipalities, taking into account the distribution of cases among men and women, by age groups 0−19 years, 20−39 years, 40−59 years, 60 years and older, using relative values.

Results. The incidence of mental disorders in the Omsk region was 3213.5 per 100 thousand people. Among both sexes, the incidence of PR in the region had a moderate downward trend (Tsn = 1.25 %; p < 0.001). There was a moderate downward trend (Tsn = 1.55 %; p < 0.001) in the incidence of psychoses and dementia among men. There were no trends in the female population and the territory of residence (Tsn. = 0.35 %; Tsn. = 1.07 % in urban areas, p < 0.001 and Tsn. = 0.8 % in rural areas, p < 0.001, respectively). In the younger (0−19 years old) and older (40−59 years old, 60 years old and older) age groups, mental disorders of a non-psychotic nature were in the lead in the structure of the incidence of PR, while mental retardation was a priority at the age of 20-39 years.

Conclusion. The incidence of mental disorders in the Omsk region exceeded the national average (by 21.5 %). In dynamics, the trend towards a decrease in the incidence of mental disorders in the region was observed among both sexes, but was largely due to a decrease in this indicator in men. In the age structure of patients with mental disorders in the Omsk region, people aged 20−39 years were in the lead for 2010−2022. A moderate tendency to an increase in the incidence of PD was revealed in the age groups of 60 years and older throughout the region (Tpr. = 1.6 %; p < 0.001), as well as in people aged 40−59 years living in rural areas.
The influence of risk factors for cardiovascular diseases on the morphofunctional properties of mesenchymal stem cells
Authors: Slesareva T. A. , Uchasova E. G. , Dyleva Yu. A. , Belik E. V. , Gruzdeva O. V.
Published: January 2025

Today, the contribution of mesenchymal stem cells (MSCs) to the mechanism of development of pathologies such as calcification of heart valves and blood vessels is being actively discussed. This is due to the fact that the formation of calcifications in the cardiovascular system (CVS) repeats the process of ossification, that is, it is mediated by specific bone cells - osteocytes. Since MSCs are progenitor cells capable of multilineage differentiation, they are considered as a source of osteocytes in the cardiovascular system. The question of what stimuli activate the osteogenesis program in MSCs localized in the CVS organs remains open. The presence of risk factors for cardiovascular diseases (CVD) has a systemic effect on the body, as it contributes to the development of pathological processes such as hypoxia and inflammation, which lead to remodeling of the MSC niche and changes in their function. This review systematizes scientific studies devoted to the influence of modifiable and non-modifiable CVD risk factors on the morphofunctional properties of MSCs.

The purpose of this review is to systematize existing knowledge about the role of modifiable and non-modifiable CVD risk factors in changing the morphology and function of MSCs.

The functioning of MSCs depends on the age of the donor and the duration of their cultivation in vitro, due to the activation of cellular aging processes. The influence of gender on MSCs is controversially described in the literature; however, there is evidence of the participation of estrogen in regulating the balance between osteogenic and adipogenic differentiation of progenitor cells. The presence of comorbid conditions such as hypercholesterolemia, obesity, and diabetes mellitus contribute to the acceleration of cellular aging, modification of the MSC phenotype, and influence the activity of their proliferation and differentiation potential. Thus, the complex of pathological processes accompanying obesity and diabetes mellitus leads to a decrease in the differentiated potential of MSCs, and also induces the expression of genes that are markers of cellular aging. An increase in the concentration of cholesterol esters in the microenvironment of MSCs induces a program of osteogenic differentiation in them, and exposure to high density lipoproteins (HDL) has a positive effect on proliferation. Cigarette smoke activates stem cell apoptosis, reduces proliferation, and induces osteogenesis.
Respon Keterlaksanaan E-Book Ilmu Lingkungan Berorientasi Conceptual Change
Authors: Febrianti Yuli , Endang Suswati  , Nopa Nopiyanti
Published: January 2025

Tujuan dalam penelitian ini adalah menganalisis keterlaksanaan e-book ilmu lingkungan berorientasi conceptual change. Penelitian ini merupakan penelitian deskriptif kualitatif melalui lembar keterlaksanaan e-book ilmu lingkungan berorientasi conceptual change. Teknik pengumpulan data dengan menggunakan kuesioner (angket) berbentuk kuesioner tertutup yang berisikan tentang aspek pengamatan yang diberikan kepada pengamat untuk mengetahui sejauh mana keterlaksanaan e-book ilmu lingkungan berorientasi conceptual change yang dibuat oleh peneliti. Adapun teknik analisis data digunakan untuk menganalisis data yang diperoleh       melalui kuesioner (angket) yang telah dinilai oleh pengamat. Analisis data yang digunakan dengan cara mengelompokkan informasi dari data hasil kualitatif yang berupa tanggapan dan hal-hal lain yang ditemukan selama pengamatan. Adapun analisis data dijadikan acuan untuk memperbaiki atau merefisi produk. Data yang diperoleh dianalisis dan diukur persentase respon pengamat melalui pedoman skor penilaian respon pengamat terhadap keterlaksanaan e-book ilmu lingkungan berorientasi conceptual change.  Hasil penelitian ini adalah perolehan skor angket yang disi oleh pengamat diperoleh jumlah skor angket 38 dan dihitung menggunakan rumus diperoleh hasil yaitu 95%. Simpulan dalam penelitian ini adalah respon yang positif dari pengamat terhadap keterlaksanaan e-book ilmu lingkungan berorientasi conceptual change sehingga layak digunakan sebagai sumber belajar mandiri.
Kata Kunci—Conceptual Change, E-Book, Ilmu Lingkungan, Kuesioner (Angket), Respon Keterlaksanaan.
Pengembangan E-Book Interaktif untuk Meningkatkan Kompetensi Siswa
Authors: Hafsah  , Nandang Hidayat  , Lufty Hari Susanto
Published: January 2025

Penelitian ini bertujuan untuk mengembangkan e-book interaktif untuk meningkatkan kompetensi siswa pada materi sistem reproduksi. Penelitian ini merupakan Research and Development (R&D) adalah model ADDIE yang dilaksanakan pada bulan April hingga Juni 2021. Populasi dan sampel pada penelitian ini adalah siswa SMAN 1 Gunungputri kelas XI MIPA 4 sebanyak 30 orang siswa. Pelaksanaan uji coba dilaksanakan secara terbatas dalam bentuk kegiatan pembelajaran dalam jaringan dengan menggunakan desain penelitian the one group pretest – postest design. Instrumen yang digunakan pada peneltian ini terdiri dari lembar validasi ahli untuk menguji kelayakan e-book interaktif, instrumen soal tes siswa untuk mengetahui kompetensi siswa, serta instrumen angket respon guru dan siswa untuk mengetahui kepraktisan e-book interaktif. Hasil penelitian menunjukkan bahwa e-book interaktif yang dikembangkan layak digunakan sebagai bahan ajar dengan rata – rata nilai validasi ahli pakar sebesar 90,3% dengan kriteria sangaat layak. Bahan ajar e-book interaktif memiliki keefektifan untuk meningkatkan kompetensi siswa pada materi sistem reproduksi dengan rata – rata nilai n-gain sebesar 0,4 (40%) dengan kriteria sedang dan tingkat efektivitas cukup efektif. Berdasarkan angket respon guru dan siswa terhadap bahan ajar e-book interaktif diperoleh sebesar 95,55% dan hasil angket siswa sebesar 82,20 % dengan kriteria sangat baik.
Potensi Tumbuhan Berkhasiat Obat di Desa Pekawai Kabupaten Melawi sebagai Sumber Belajar Biologi
Authors: Nursela Agustin , Setiadi Anandita Eka , Qurbaniah Mahwar
Published: January 2025

Pengalaman belajar yang konkrit dengan mengamati objek secara langsung dapat dilakukan dengan memanfaatkan jenis tumbuhan berkhasiat obat yang ada di lingkungan sekitar sebagai sumber belajar siswa. Penelitian ini bertujuan untuk menginventarisasi jenis-jenis tumbuhan berkhasiat obat yang digunakan masyarakat Desa Pekawai dan potensinya sebagai sumber belajar biologi. Penelitian ini menggunakan metode kualitatif deskriptif. Teknik pengumpulan data menggunakan observasi, angket, wawancara dan dokumentasi. Hasil penelitian menunjukan terdapat 23 jenis tumbuhan berkhasiat obat yang digunakan masyarakat Desa Pekawai yaitu Jeruk Nipis, Nangka , Kelapa, Pare, Seledri, Kemangi ,Insulin, Rambutan, Pepaya, Kumis Kucing, Sirih, Cucur Bebek, Terong pipit, Alang-Alang, Jahe, Kencur, Kunyit, Temulawak, Srikaya, Sirsak, Jambu Biji, Pinang, Belimbing Wuluh. Potensi tumbuhan berkhasiat obat berdasarkan mata pelajaran kelas X, yaitu ruang lingkup Biologi, Keanekaragaman Hayati, dan Klasifikasi Makhluk Hidup dan Tumbuhan. Tumbuhan obat sangat cocok sebagai sumber pembelajaran biologi SMA. Potensi tumbuhan berkhasiat obat sebagai sumber belajar biologi sangat layak berdasarkan indikator kejelasan potensi (85%), kejelasan sasaran (84%), kesesuaian tujuan (88%), kejelasan informasi (82%), kejelasan eksplorasi (84%), dan kejelasan hasil (82%).
Pengaruh Pembelajaran Biologi Berbasis Proyek pada Kurikulum Merdeka terhadap Kemampuan Berpikir Kritis di SMA Muhammadiyah Langsa
Authors: Listya Dinda , Sarjani Tri Mustika , Ariska Raja Novi
Published: January 2025

Penelitian ini bertujuan untuk mengetahui pengaruh pembelajaran biologi berbasis proyek pada kurikulum merdeka terhadap kemampuan berpikir kritis di SMA Muhammadiyah Langsa. Penelitian ini menggunakan jenis penelitian eksperimen dengan pendekatan kuantitatif. Desain yang digunakan dalam penelitian ini adalah one group pretest-posttest design.  Sampel penelitian ini adalah siswa/siswi kelas X1 (Eksperimen) dan X2 (Kontrol) SMA Muhammadiyah Langsa dengan jumlah 33 siswa. Hasil penelitian meinunjukkan bahwa nilai rata-rata preiteist keilas eikspeirimein seibeisar 41,5 dan keilas kontrol seibeisar 30,65. Seidangkan nilai rata-rata postteist keilas eikspeirimein seibeisar 74,80 dan keilas kontrol seibeisar 51,15. Data dianalisis meinggunakan uji t-teist Polleid Varian. Beirdasarkan uji hipoteisis nilai postteist seibeisar 5,21 deingan taraf signifikan α = 0,05 maka dipeiroleih ftabeil = 2,04 deingan keiteintuan fhitung > ftabeil , 5,21 > 2,04 maka Ho ditolak dan Ha diteirima seihingga dapat disimpulkan teirdapat peingaruh dalam meinggunakan modeil peimbeilajaran beirbasis proyeik teirhadap keimampuan beirpikir kritis siswa di SMA Muhammadiyah Langsa. Dan rata-rata untuk peinilaian karya dari siswa seibeisar 73,43.
Elephant Endotheliotropic Herpesvirus Infection in Asian Elephants (Elephas maximus): A Review
Authors: Alkausar Triawan , Kamelia Marlina , Yosilia Rani , Anisya Shinta , Satitiningrum Yuni
Published: January 2025

Elephants are charismatic exotic animals. As the largest land animal on the earth, their maximum weight can reach more than 7 tons and 4 meters in height. Apart from their exoticness, however, elephants, particularly Asian elephants are now losing more than 70% of their habitat. As a result, the International Union for Conservation of Nature (IUCN) has red-listed Asian elephants as the critically endangered animal. Various conservation efforts have been implemented, such as translocation of the elephants, control of poaching, educational campaigns, and research. Nonetheless, over the past two decades, Elephant Endotheliotropic Herpesvirus (EEHV), a newly emerging disease has caused a serious threat to Asian elephants’ health worldwide. The virus causes a rapid, acute, and fatal haemorrhagic disease as the major clinical manifestation in adult Asian elephants and particularly in juvenile elephants in both wild and captive populations. This article provides a literature review regarding the EEHV infection in Asian elephants.
Bioprospecting Test of Piper betle Leaf Essential Oil Against Staphylococcus Aureus and Escherichia Coli-Antibiotic Resistant
Authors: Anindita Reza , Beandrade Maya Uzia , Putri Intan Kurnia
Published: January 2025

One of the efforts to overcome antibiotic resistance is the bioprospection of natural materials that have the potential to be antibacterial. One of the results of distilling natural materials with antibacterial potential is betel leaf essential oil (Piper betle). This study aimed to determine the effect of essential oils on Staphylococcus aureus and Escherichia coli-resistant antibiotics. The design of this study is experimental, with independent variables in the form of essential oils with concentrations of 5%, 10%, 15%, 20%, 25%, and 100%. In contrast, the dependent variable is the diameter of the growth inhibition zone of S. aureus and E.coli bacteria.  Essential oil extraction using steam distillation and chemical characterization by GC-MS test. Antibacterial testing uses the Kirb-Bauer method. GC-MS test results were dominant eugenol (3.50%), caryophyllene (3.79%), and Germacrene D (1.19%). The application of essential oils was able to inhibit the growth of S. aureus with inhibition zone diameters of 10.5 mm (moderate), 10.6 mm (moderate), 10.8 mm (moderate), 12.3 mm (strong), 14 mm (strong), and 30.2 mm (very strong), while E. coli was 5.7 mm (moderate), 7.5 mm (moderate), 10.5 mm (moderate), 12 mm (strong), and 30.03 mm (very strong). The results of the ANOVA one-way test showed a value of 11762.7, while the F table was 3.48 (Fcal > Table). This study concludes that administering essential oils with concentrations of 5%, 10%, 15%, 20%, 25%, and 100% can significantly inhibit the growth of S. aureus and E.coli bacteria.
Penerapan Model Inkuiri Berbasis Etnobiologi Terhadap Hasil Belajar Peserta Didik Di SMPN 11 Satarmese
Authors: Df Denita , Ainun Jariyah  , Veronika P. Sinta Mbia Wae
Published: January 2025

Penelitian ini bertujuan untuk mengetahui penerapan model inkuiri berbasis etnobiologi terhadap hasil belajar peserta didik di SMP Negeri 11 Satarmese. Jenis penelitian yang digunakan dalam penelitian ini adalah deskriptif kuantitatif. Desain yang digunakan dalam penelitian ini pre-experiment one group pretest-post-test. Variabel terikat dalam penelitian ini adalah hasil belajar peserta didik di SMP Negeri 11 Satarmese, sedangkan variabel bebas adalah model inkuiri berbasis etnobiologi. Populasi dalam penelitian ini berjumlah 98 peserta didik yang terdiri dari tiga kelas yaitu kelas VII – IX. Sampel dalam  penelitian ini adalah kelas VII yang berjumlah 26 peserta didik yang diperoleh dengan teknik purposive sampling. Data yang diperoleh dari sampel penelitian berupa hasil belajar peserta didik yang terdiri dari aspek kognitif. Analisis data dilakukan dengan uji t menggunakan program bantuan SPSS for windows versi 25. Hasil penelitian menunjukan bahwa penerapan model inkuiri berbasis etnobiologi berpengaruh terhadap hasil belajar pesera didik kelas VII SMP Negeri 11 Satarmese. Hal ini dapat dilihat dari hasil pre-test  dan post-test peserta didik. Hasil belajar kognitif setelah diberi perlakuan mengalami peningkatan sebesar 85,49. Uji hipotesis hasil belajar peserta didik kelas eksperimen menunjukan bahwa nilai signifikan<0,05. Dengan demikian dapat dikatakan bahwa H0 ditolak dan H1 diterima atau ada pengaruh penerapan model inkuiri berbasis etnobiologi terhadap hasil belajar IPA SMP Negeri 11 Satarmese
Implementasi Model Pembelajaran Connecting, Organizing, Reflecting, Extending Terhadap Hasil Belajar Siswa di SMP Negeri 7 Langsa
Authors: Isnani Yatul Husna  , Nursamsu  , Abdul L. Mawardi
Published: January 2025

Banyak faktor yang memengaruhi hasil belajar siswa, terutama pada model pembelajaran yang digunakan. Pada penelitian ini peniliti menggunakan model pembelajaran Connecting, Organizing, Reflecting, Extending (CORE). Pokok permasalahan yang diungkapkan dalam penelitian ini adalah sejauh mana pengaruh hasil siswa dalam menerapkan model pembelajaran Connecting, Organizing, Reflecting, Extending (CORE). Tujuan dari penelitian ini untuk mengetahui peningkatan hasil belajar peserta didik menggunakan model pembelajaran Connecting, Organizing, Reflecting, Exending (CORE). Penelitian ini merupakan penelitian kuantitatif. Teknik pengumpulan data tes hasil belajar yang berbentuk pilihan ganda. Teknik analisis data dilakukan secara kuantitatif yaitu dengan uji hipotesis dan uji N-Gain. Hasil penelitian menunjukkan bahwa terdapat peningkatan hasil belajar siswa berdasarkan hasil uji hipotesis dengan perolehan thitung > ttabel yaitu 10,3242 > 2,704. Peningkatan hasil belajar siswa dapat dilihat dari perolehan hasil rata-rata nilai N-gain sebesar 0,58 dan kriteria peningkatan hasil belajar yaitu 58% pada kategori cukup efektif. Dengan demikian, hipotesis dalam penelitian ini dapat diterima dan disimpulkan bahwa terdapat peningkatan hail belajar siswa yang signifikasi dari penerapan model pembelajaran Connecting, Organizing, Reflecting, Extending (CORE).
Pengembangan E-LKPD Berbasis Literasi Sains Pada Materi Sistem Reproduksi Manusia Kelas XI SMAN 4 Kupang
Authors: AGUSTINUS SALEMA  , Agus Maramba Meha  , James Ngginak
Published: January 2025

Penelitian ini bertujuan untuk menghasilkan E-LKPD berbasis literasi sains yang dapat membantu dan memudahkan peserta didik dalam mempelajari biologi. Metode penelitian yang digunakan adalah Research and Development (R&D) atau penelitian pengembangan. Penelitian ini menggunakan model pengembangan 4D dengan tahapan yaitu 1) Define 2) Desain 3) Development 4) Dessminate. Rangkaian tahapan tersebut meliputi validasi ahli (ahli media, ahli bahasa, dan ahli materi), uji coba kelompok keci dan uji coba kelompok besar. Hasil validasi produk E-LKPD berbasis literasi sains oleh ahli media yaitu sebesar 100%, ahli bahasa sebesar 85,71%, ahli materi sebesar 92,85%, uji coba kelompok kecil sebesar 88,28%, uji coba kelompok besar sebesar 85,80%. Berdasarkan hasil penilaian yang diberikan oleh ahli media, ahli bahasa, ahli materi, dan peserta didik dapat disimpulkan bahwa E-LKPD berbasis literasi sains dikatakan valid dan layak di gunakan sebagai sumber belajar.
COVID-19 HEALTHCARE WORKER BURNOUT: WORK ENVIRONMENT AND WORKLOAD AS INFLUENCING FACTORS
Authors: Ardhianti Ulva , Sary Fetty Poerwita
Published: January 2025

The COVID-19 pandemic is an unexpected event. Hospitals must maintain the burnout level of health workers to maintain optimal energy in providing health services. One way to keep the burnout level of health workers in X Hospital is to pay attention to the work environment and workload. The non-probability sampling method used in this research is quantitative with descriptive research analysis. The analytical method used is multiple linear regression. The results showed that the work environment variables were not good, and workload and burnout were in a relatively high category. Results based on a coefficient of determination of 18.2% burnout in health workers caring for COVID-19 patients at Hospital X are influenced by the physical work environment and workload. This study concluded that the physical work environment and workload significantly affected the burnout of health workers treating COVID-19 patients at X Hospital.
Lasten suun terveyden väestöryhmäerot ja niihin vaikuttaminen
Authors: Milén Anneli
Published: January 2025

Alle kouluikäisten lasten hampaiden terveydentilassa on suuria sosiaaliryhmittäisiä eroja, jotka järjestelmällisen, maksuttoman ja ehkäisyyn painottuneen suun terveydenhuollon toimenpiteillä eivät ole kaventuneet. Kouluikäisten lasten ja nuorten hampaiden kunnon erot ovat vähäisemmät kuin pikkulapsilla. Lasten ja nuorten hampaiden terveyden alueelliset erot ovat pienentyneet kansanterveystyön aikana. Artikkelissa pohditaan sosioekonomisiin karieseroihin vaikuttavia tekijöitä sekä mahdollisuuksia erojen poistamiseen.
Viljelijäväestön mielenterveyden ongelmien seulonta ja työterveyshuolto
Authors: Raitasalo Raimo , Notkola Veijo
Published: January 2025

Tutkimukseen kuului 874 viljelijää, joiden terveydentila tutkittiin terveyskeskuslääkäreiden toimesta. Depressiivisyyttä, ahdistuneisuutta ja psykosomaattista oireilua kartoitettiin DE-oirekyselyllä. Naisista oli depressiivisesti oireilevia 15 % ja miehistä 12 %. Oireilu oli vanhoilla viljelijöillä yleisempää kuin nuorilla. Käytetyn kyselyn perusteella ohjattiin jatkohoitoon 8 % tutkituista eli noin 60 % depressiivisesti oireilevista.
Käytettäessä DE-oirekyselyä seulontamenetelmänä työterveyshuollossa lienee mahdollista aiempaa osuvammin kartoittaa depressiivisesti, ahdistuneesti tai psykosomaattisesti oireilevat viljelijät. DE-oirekyselyä kehitetään edelleen sekä käytännön avoterveydenhuoltoon että tutkimustyöhön soveltuvaksi tutkimusmenetelmäksi.