bluuebunny/crossref_metadata_2025 huggingface dataset:
Pandemic decrease of in-person physiotherapy as a factor in parent perceived decline in function in children with neuromuscular disorders
Authors: Stępień Agnieszka , Sobińska Małgorzata , Rekowski Witold , Krawczyk Maciej Julian
Published: December 2022

PURPOSE: Restrictions related to the COVID-19 pandemic can negatively affect patients who require physiotherapy. This study aimed to analyze the consequences of limited physiotherapy on the functional state of children with neuromuscular diseases (NMD). In addition, the caregivers’ well-being and caregiver opinions on physiotherapy were analyzed. METHODS: A questionnaire was shared with parents of children with NMD immediately after the COVID-19 lockdown. The survey included questions regarding the physical and mental condition of children and parents before the pandemic and during lockdown as well as their views on physiotherapy and telephysiotherapy. Statistical analysis was performed using the Wilcoxon Matched-Pairs Signed Ranks test, Spearman’s Rank Correlation test, McNemar test, and Chi-square test. RESULTS: Parents of 235 children participated in the study. Results indicated that children devoted more time to physiotherapy before the pandemic than during the lockdown period, which was true for those living in cities and the countryside. The functional state of 50.2% of the children deteriorated during the lockdown, in the opinion of their parents. Significant correlations were found between limited physiotherapy time and the deterioration of children’s functional condition, ability to maintain a standing position, and increased anxiety. The majority of parents reported increased levels of fear and anxiety (72.8%), fatigue (67.7%), and pain (53.2%). In-person physiotherapy was rated significantly higher than telephysiotherapy by parents. CONCLUSIONS: Limited access to physiotherapy and shorter therapy times may lead to functional deterioration in children with NMD, but this assumption needs to be objectively confirmed. According to the parents’ opinions, telephysiotherapy is less beneficial than direct physiotherapy but may support therapy conducted directly by a physiotherapist. Results based on subjective parental opinions may be helpful in planning future projects.
Tourism GDP for 2010 to 2020: New TSA results for Greece
Authors: Hackl Peter , Hatzimarinakis Stavros
Published: December 2022

In many countries, early attempts in implementing TSA Tables suffer from limitations in available data. For Greece, pilot TSA Tables 1 to 6 were implemented in an EU-funded project for the reference year 2015. However, TSA Table 6 could not be implemented in all details, mainly due to limited resources of ELSTAT, the national statistical office. TSA Tables were not implemented for the years after 2015, partly due to needs for improving the TSA-related database which were revealed in the pilot project. Our paper presents methods for implementing the TSA Table 6 given only limited data on tourism expenditures and Supply and Use Tables and provides estimates of the Tourism Direct GPD for 2010 through 2020. Besides the methodological approach, our results show a rather pleasing picture of Greek tourism. In the years 2010 to 2019, Tourism Direct GDP was steadily growing and increased from 7,026 to 10,994 million Euros, an average annual growth rate of 5.1%; the GDP decreased annually by 2.2% on average. The TDGVA ratio increased from 3.1% to 5.5% and the TDGDP ratio from 3.1% to 6.0%, the average annual growth rate of the Tourism Direct GVA and GPD ratios amounting to 6.7% and 7.5%, respectively.
A novel method for conformity assessment testing of therapeutic ultrasounds for post-market surveillance purposes
Authors: Badnjevic Almir , Deumic Amar , Ademovic Azra , Pokvic Lejla Gurbeta
Published: December 2022

BACKGROUND: Therapeutic ultrasounds are medical devices used for treatment of conditions such muscle spasms, joint contractures or general muscle pain. Their function relies in the delivery of ultrasonic pulses that generate heat in tissue thus relieving the symptoms of aforementioned conditions. Accuracy of the delivered pulses directly affects the quality and effectiveness of the treatment and has to be ensured throughout the utilization of the therapeutic ultrasound in practice. The new Medical Device Regulation (MDR) defines medical device post-market surveillance (PMS) as performed by independent, third-party, notified bodies more strategically in hope to improve traceability of device performance. However, there is still an apparent gap in terms of standardised conformity assessment testing methods. OBJECTIVE: This paper proposes a novel method for conformity assessment testing of therapeutic ultrasounds for post-market surveillance purposes. METHOD: The method was developed based on metrology characteristics of therapeutic ultrasounds and includes visual, electrical safety and performance inspections of therapeutic ultrasounds to ensure that both safety and treatment reliability are achieved. RESULTS: The developed method was validated between 2018 and 2021 in healthcare institutions of all levels. The results obtained during validation suggest that conformity assessment testing of therapeutic ultrasounds as a method used during PMS contributes to significant improvement in devices’ accuracy and reliability. CONCLUSION: A standardized approach in conformity assessment testing of therapeutic ultrasounds during PMS, besides increasing reliability of the devices, is the first step in digital transformation of management of these devices in healthcare institutions opening possibility for use of artificial intelligence.
A novel method for conformity assessment testing of infusion and perfusion pumps for post-market surveillance purposes
Authors: Badnjevic Almir , Deumic Amar , Smajlhodzic-Deljo Merima , Pokvic Lejla Gurbeta
Published: December 2022

BACKGROUND: Introduction of fluids, medicaments and nutrients into the human body during hospitalization is fundamental for treatment and healing of patients. Fluids are introduced by means of infusion pumps while nutrients and medicaments are introduced by perfusion pumps. It is of vital importance for these devices to deliver exact amounts of the aforementioned substances as significant deviations can result in severe patient harm. Therefore it is important to effectively monitor their performance and prevent failures. OBJECTIVE: This paper proposes a novel method for conformity assessment testing of infusion and perfusion pumps for post-market surveillance purposes. METHOD: The method was developed on the basis of metrology characteristics of the devices. In addition to the evaluation of essential safety and visual integrity of infusion and perfusion pumps, their performance in terms of delivered volumes was assessed and monitored. RESULTS: The developed method was validated between 2018 and 2021 in healthcare institutions of all levels. The results obtained during validation suggest that conformity assessment testing of infusion and perfusion pumps as a method used during PMS contributes to significant improvement in devices’ accuracy and reliability. CONCLUSION: A standardized approach in conformity assessment testing of infusion and perfusion pumps during PMS, besides increasing reliability of the devices, is the first step in digital transformation of management of these devices in healthcare institutions opening possibility for use of artificial intelligence.
A novel method for conformity assessment testing of mechanical ventilators for post-market surveillance purposes
Authors: Badnjevic Almir , Deumic Amar , Trakic Ammar , Pokvic Lejla Gurbeta
Published: December 2022

BACKGROUND: Mechanical ventilators are medical devices used in intensive care units when patients are in need of mechanical aid to facilitate the process of breathing. As the function of breathing is the exchange of gases, the mechanical ventilator takes over that function while the patient is incapable to spontaneous breathing. As these devices are used to maintain the life of patents, their performance must be ensured and there cannot be significant deviations in the volumes and pressure of gases they introduce to the patient. The new Medical Device Regulation (MDR) defines medical device post-market surveillance (PMS) as performed by independent, third-party, notified bodies more strategically in hope to improve traceability of device performance. However, there is still an apparent gap in terms of standardised conformity assessment testing methods. OBJECTIVE: This paper proposes a novel method for conformity assessment testing of mechanical ventilators for post-market surveillance purposes. METHOD: The method was developed on the basis of metrology characteristics of mechanical ventilators and evaluation of their vital safety and performance parameters. In addition to the evaluation of essential safety and visual integrity of mechanical ventilators, their performance in terms of volume of oxygen delivered to the patient as well as the flow and pressure of the delivered gas is evaluated. RESULTS: The developed method was validated between 2018 and 2021 in healthcare institutions of all levels. The results obtained during validation suggest that conformity assessment testing of mechanical ventilators as a method used during PMS contributes to significant improvement in devices’ accuracy and reliability. CONCLUSION: A standardized approach in conformity assessment testing of mechanical ventilators during PMS, besides increasing reliability of the devices, is the first step in digital transformation of management of these devices in healthcare institutions opening possibility for use of artificial intelligence.
The effect of physical activity breaks, including motor-cognitive coordination exercises, on employees’ cognitive functions in the workplace
Authors: Buuck Sabine , Voll Stefan , Jansen Petra
Published: December 2022

BACKGROUND: The findings of the effectiveness of physical activity on adults’ cognitive abilities have not yet been transferred into corresponding fields of application. OBJECTIVE: The present study evaluates a motor-cognitive coordination programme in a company to improve employees’ cognitive performance in the short and medium term. METHODS: A total of 67 employees — 32 men and 35 women aged between 19 and 61 years — participated in this study, and 55 completed the study. The sample was randomly divided into an experimental group, which received a motor-cognitive coordination training, and a control group, which received a relaxation and mobility training. Both groups met for 15-minute sessions three times a week for eight weeks. Before and after the intervention, working memory, attention, information-processing capacity, divergent thinking, and mood were measured. In addition, acute effects regarding attention and mood were tested. RESULTS: The results showed that the motor-cognitive coordination break improves working memory and divergent thinking after eight weeks of intervention, whereas neither the mood nor the information processing speed improved more for the experimental group compared to the control group. The results on the acute increase in attention performance failed to reach significance. CONCLUSION: The new approach of this study was not only the derivation and development of targeted exercises, but also their testing and evaluation in the field of application. Motor-cognitive coordination exercise in the workplace might play an important role in both occupational health management and personnel development, especially for companies that are under highly competitive and innovative pressure.
Intervención integral y multidisciplinaria en pacientes con fibromialgia de atención primaria de salud de la comuna de pelarco, con enfoque de médico familiar
Authors: González Gutierrez Claudia , Schorwer Alarcón Gerardo
Published: December 2022

Objetivo: evaluar el efecto de intervenciones grupales multidisciplinarias por equipo de atención primaria de salud, guiadas por médico de familia sobre los síntomas, calidad de vida y dinámica familiar de pacientes con fibromialgia. Metodología: estudio longitudinal comparativo. Las participantes fueron 20 pacientes adultas diagnosticadas clínicamente con fibromialgia pertenecientes al CESFAM de la comuna de Pelarco, región del Maule, Chile. El protocolo de actividades se basó en talleres semanales con equipo multidisciplinario integrado por kinesiólogo, nutricionista, psicólogo y médico de familia. Resultados: el abordaje multidisciplinar mejoró significativamente los indicadores de calidad de vida y dinámica familiar a su vez que disminuyeron significativamente los síntomas clínicos de dichos pacientes (p<0.05). Conclusión: las pacientes con diagnóstico de fibromialgia tuvieron mejorías significativas en su cuadro clínico mediante un abordaje multidisciplinar de su condición funcional.
The Correlation Between the Mental Health of Children With Cancer and Their Mothers
Authors:   Department of Psychiatry, School of Medicine, Hajar Hospital, Shahrekord University of Medical Sciences, Shahrekord, Iran., Bagheri Vanani Elham , Fekri Kiavash ,   Department of Psychiatry, School of Medicine, Hajar Hospital, Shahrekord University of Medical Sciences, Shahrekord, Iran., Raeisi Shahraki Hadi ,   Department of Psychiatry, School of Medicine, Hajar Hospital, Shahrekord University of Medical Sciences, Shahrekord, Iran., Safavi Parvin ,   Department of Psychiatry, School of Medicine, Hajar Hospital, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Published: December 2022

Background and Purpose: Childhood cancer can affect the adjustment of children and their parents, especially their mothers. This study aimed to assess the correlation between the general health and illness perception of mothers of children with cancer with the quality of life of their children. Materials and Methods: This research was a cross-sectional study conducted on 100 children with cancer and their mothers referred to Ayatollah Kashani Hospital in Shahrekord City, Iran, from 2019 to 2021. They were selected by convenience sampling. The study data were collected by the general health questionnaire, brief illness perception questionnaire, questionnaire on the quality of life (QoL) of preschool children (1-6 years old), and questionnaire on the QoL of children (aged 8-12 years). The Pearson correlation test was used for data analysis. Results: Among the children with cancer, 43 were girls, and 57 were boys. The Mean±SD age of the children was 7.67±3.48 years. The results of the Pearson correlation test showed a significant correlation between the general health of mothers with the QoL of preschool children (r=-0.70, P<0.001) and the QoL of primary school children (r=-0.64, P<0.001) as well as the QoL of primary school children (completed by parents) (r=-0.65, P<0.001). The correlation between illness perception and other variables, such as the quality of life of preschool children (r=0.21, P=0.19) and the QoL of primary school children (r=0.18, P=0.18), were not statistically significant. Conclusion: Due to a significant correlation between mothers’ general health with the QoL of children with cancer, it is recommended that the medical and nursing team benefit from psychological interventions in this field for mothers and children with cancer.
Oral Problems and Psychological Status of Older Adults Referred to Hospital and Its Relationship With Cognition Status, Stress, Anxiety, and Depression
Authors:   Department of Geriatrics, Research Center on Aging, School of Social Welfare, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran., Papi Shahab , Hosseini Seyed Vahid ,   Department of Geriatrics, Research Center on Aging, School of Social Welfare, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran., Bahadori Farzaneh ,   Department of Geriatrics, Research Center on Aging, School of Social Welfare, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran., Rezapour Vahideh ,   Department of Geriatrics, Research Center on Aging, School of Social Welfare, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran., Moghadasi Amir Mohamad ,   Department of Geriatrics, Research Center on Aging, School of Social Welfare, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran., FadayeVatan Reza ,   Department of Geriatrics, Research Center on Aging, School of Social Welfare, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
Published: December 2022

Background and Purpose: Oral health is a critical factor in the quality of life (QoL) of older adults in relation to their nutrition, mental health, and healthy social relationships. This study aimed to investigate oral problems and psychological status of older adults referred to a hospital and its relationship with cognition status, stress, anxiety, and depression. Materials and Methods: This cross-sectional study was conducted among 300 older adults referred to Shahid Beheshti Hospital in Shiraz City, Iran. The “Depression, Anxiety, Stress Scale”, the “Abbreviated Mental Test score”, and the “General Oral Health Assessment Index” were used to collect the required data. The Pearson correlation and multiple linear regression statistical tests were used to analyze the data in SPSS v. 26. P less than 0.05 were considered significant. Results: The Mean±SD age of the participants was 70.1±4.6 years. Their mean±SD score of oral health was 44.83±3.91, and the mean±SD cognitive status was 9.28±0.9. The results of correlation analysis revealed a significant relationship between the dimensions of mental health (cognitive status, stress, anxiety, depression) and oral health (P<0.05). According to the multiple linear regression model, there was a significant relationship between oral health and cognitive status (P=0.002) and between oral health and stress (P=0.015). Conclusion: The study’s results showed a correlation between mental health and oral health. Thus, one of the ways to improve the mental health of the elderly is to provide appropriate and timely dental intervention.
Gut microbiome diversity as adjuvant marker for immune function
Authors: Mahdaleny  , Iswanti Febriana Catur
Published: December 2022

The gastrointestinal (GI) tract represents our most intimate contact with the external environment. The GI tract responsible for extracting the appropriate nutrients we need to thrive, maintaining an appropriate balance of helpful and harmful microbes, and acting as a conduit for waste removal. In essence, the extracellular matrix of gut mucosal biofilm is a complex network of microbes and their secretions, as well as the host's secretions and signals (mainly mucus/mucin). Mucin, bacterial polysaccharides, and protein combine to form a unique mucosal biofilm that serves as a home for a variety of commensal and pathogenic organisms in the host. Maintaining proper mucosal barrier function is vital for both GI and systemic health. The lumen of the gut contains numerous entities that should never reach the bloodstream or lymphatic system. The mucosal barrier's integrity is maintained by a single layer of tightly fitted columnar epithelial, and more than 70% of the immune system components are closely associated with the GI tract.
Mobilization economy: current issues of today
Authors:   Market Economy Institute of RAS, Tsvetkov Valery A. ,   Department of Economic Theory at the Financial University under the Government of the Russian Federation
Published: December 2022

The article raises questions concerning the mobilization economy: what is a mobilization economy and according to what principles it is based on, what are its features, and as well as the conditions for transition to it. Three different models of the «mobilization economy» are considered, with different objectives, different tools and different variants for its implementation: the economy of resource mobilization; anti-crisis mobilization economy; the mobilization economy of wartime. The advantages and disadvantages of the mobilization economy are analyzed. It is concluded that in the current conditions of Russia it is absolutely necessary to change the model of the national economy with the introduction of additional elements of resource mobilization, which will provide new incentives for economic growth and social development.
Motiváció lehetőségei a felsőoktatásban covid-19 után személyiségjellemzők alapján
Authors: Bekk Tímea , Pogátsnik Monika
Published: December 2022

2019-ben kezdődő és napjainkra is hatással lévő Covid19 sok változást hozott az oktatás, ezen belül a felsőoktatás világába. A jelenléti oktatás visszatértével általános az a tapasztalat, hogy a hallgatók kevésbé motiváltak, nehéz ösztönözni őket. Kutatásunkban megvizsgáltuk, hogy az MBTI személyiségteszt által definiált típusok esetén milyen eltérések tapasztalhatók, mely motivációs módszerek a sikeresebbek. Kutatásunk két elemből állt, egy előzetes kvalitatív kutatást, majd egy kvantitatív kutatást végeztünk. A kvalitatív kutatás fókuszcsoportos beszélgetések formájában zajlott. A beszélgetések a hallgatói oldalról adtak inputot a motiváció tárgykörében, melyek feldolgozása alapján készült el a kutatás második fázisához a kvantitatív kutatásunkban alkalmazott kérdőív. A kvantitatív kutatás során első lépésben a hallgatók az MBTI tesztet töltötték ki, és ezt követően válaszoltak az összeállított motivációs kérdéssorra. A kutatás eredményeiből azt állapítottuk meg, hogy a különböző típusú embereket más-más módszerekkel tudjuk motiválni. A tanulás-tanítás módszerei mellett nagy szerepet játszik a motivációban az egyetem környezete, az iskolai elfoglaltságon kívüli közös programok, és a tanár-diák személyes viszony is.
Impact of the COVID-19 Pandemic on Tertiarycare University Dermatology Outpatient Clinic and Dermatology Procedures
Authors: Wamaphutta Kingkaew , Thasen Chowalit , Sereeaphinan Chudapa , Chaweekulrat Pichanee , Boonchai Waranya
Published: December 2022

Objective: This study aimed to determine the changes in patient characteristics, disease prevalence, and dermatology procedures during the COVID-19 pandemic.

Materials and Methods: We retrospectively reviewed the demographic data, diagnoses, and dermatology procedures of the patients who visited an outpatient dermatology clinic between March 1, 2018, and December 31, 2021. Changes in the number of patients, the patterns of diagnosis, and the dermatology procedures were analyzed.

Results: The number of patients decreased at the start of each of the 4 COVID-19 waves that occurred during the study period. Older adults increased their dermatology visits during the pandemic. The skin disease with the highest proportional increase in the frequency of visits was cutaneous T-cell lymphoma. The proportion of noncosmetic procedures significantly increased, in contrast to a decrease in the proportion of cosmetic procedures.

Conclusion: The COVID-19 pandemic significantly affected outpatient dermatology by changing the setting and frequency of patient visits to the outpatient clinic, the pattern of the diseases, and the dermatology procedures.
Opportunities and Prospects for Russia to Create Pet Centers Based on Generator Radionuclides
Authors:   National Research Center “Kurchatov Institute”, Moscow, Russia, Shimchuk G.G. , Bruskin A.B. ,   A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia, Shimchuk Gr.G. ,   National Research Center “Kurchatov Institute”, Moscow, Russia
Published: December 2022

An assessment of the capabilities of generator radionuclides and a list of generator pairs of radionuclides whose daughter isotope has the potential to be used in medicine for PET research is given. A list of typical 68Ga-based PET radiopharmaceuticals for oncology studied in preclinical and clinical studies is provided. Data on the use of the 82Sr/82Rb generator in clinical diagnostics are presented. The assessment of the existing situation with PET centers in Russia is given. A strategy for the development of a network of clinical PET centers and an overview of the state of generator technologies in Russia are proposed. This article concludes that the use of generators makes it possible to significantly expand the range of clinical institutions capable of providing PET diagnostics and conducting PET studies, having only 1 or several PET scanners in the clinic. It is concluded that due to a serious reduction in capital investments (by 1.5 times) and a noticeable reduction in the cost of operation (by 1.5‒2 times), the use of generator systems will significantly reduce the cost of many PET diagnostic procedures in oncology and cardiology, make this method more accessible to a wide range of the country’s population.
Comparison of Bone Scan, X-Ray, Spect/Ct and Mri in the Diagnosis of Bone Metastases in Solid Tumors
Authors:   N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russia, Prokhorov S.N. , Kochergina N.V. ,   N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russia,   Russian Medical Academy of Continuous Professional Education, Moscow, Russia, Ryzhkov A.D. ,   N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russia,   Russian Medical Academy of Continuous Professional Education, Moscow, Russia, Krylov A.S. ,   N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russia, Bludov A.B. ,   N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russia
Published: December 2022

Purpose: Comparison of the diagnostic performance of osteoscintigraphy (OSG), X-Ray, the presence of OSG and X-ray, SPECT/CT and a combination of MRI sequences in metastatic lesions of the bones of the skeleton. Material and methods: The study included 24 patients with bone metastases. The above research methods were used. Results: The sensitivity of X-ray, Bone scan, X-ray combined with bone scan, SPECT/CT, T1+DWI, T1+STIR+DWI, T1+T2+STIR+DWI, T1+T2+STIR was 10, 30, 24, 31, 99, 99, 99, 95 % respectively, specificity – 37, 12, 59, 74, 87, 87, 87, 71 % respectively. According to the results of pairwise comparison of true-positive results in groups according to the Wilcoxon test: X-ray < OSG = X-ray + OSG = SPECT / CT < MRI + DWI > MRI. Conclusion: It follows from the results that the choice of diagnostic method for suspected bone metastases should be determined by the clinical context. MRI will help detect bone metastases at earlier stages of development, and the use of other diagnostic methods included in the study should be accompanied by an understanding of the limitations that are imposed in their use.
Visualization of the Pathology of the Chest Organs in Children and the Possibility of Reducing Radiation Exposure
Authors:   Central Research Institute of Tuberculosis, Moscow, Russia, Petrakova I.Yu. , Tyurin I.E. ,   N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russia,   Russian Medical Academy of Continuous Professional Education, Moscow, Russia, Gubkina M.F. ,   Central Research Institute of Tuberculosis, Moscow, Russia,   N.I. Pirogov Russian National Research Medical University, Moscow, Russia
Published: December 2022

Introduction Possibilities of alternative imaging methods without the use of ionizing radiation Possibilities of optimizing the radiation load in diagnostic methods using ionizing radiation Features of the organization of work during the examination of children and anesthesiological support Conclusion
Diverse renal manifestations of Alagille syndrome in Korean children
Authors: Joung Jinwoon , Kim Mi Jin , Cho Heeyeon
Published: December 2022

Purpose: To determine the prevalence, clinical manifestations, and outcomes of renal involvements in pediatric Alagille syndrome (ALGS).Methods: A total of 21 patients diagnosed with ALGS at age under 18 years who visited Samsung Medical Center from March 1999 to March 2022 were enrolled. ALGS was diagnosed either by clinical manifestations, targeted JAG1 sequencing, and/or liver biopsy. Medical records including sex, age, renal manifestations, urinalysis, serum creatinine, JAG1 sequencing, and ultrasonography were retrospectively reviewed.Results: The male to female ratio was 9:12. The mean age of patients at confirmative diagnosis of ALGS was 18.4 months. Sanger sequencing was performed for 17 patients. Sixteen of 21 patients (76.1%) showed JAG1 mutations. Renal involvement was found in 10 patients (47.6%). The most common type of anomaly was renal dysplasia (40%). One patient having renal dysplasia was pathologically confirmed with glomerular lipid deposition. Two patients (20%) manifested nephrocalcinosis/nephrolithiasis. Among eight renal-involved patients who survived, four (50%) progressed to chronic kidney disease stage 3. Two of these chronic kidney disease patients were diagnosed with hepatorenal syndrome. The other four patients had renal functions preserved, including two without any interventions and two who underwent urological interventions.Conclusions: The current study revealed a high prevalence of renal involvement in Korean pediatric ALGS with diverse phenotypes.
Do the training system and spacing affect the productivity and quality of tomato plants?
Authors: Dipple Fernanda Lourenço , Ponce Franciely da Silva , Toledo Claudia Aparecida de Lima , Silva Rejeane Maria da , Rocha Rafael Rosa , Salamina Bruno Alexis Zachrisson , Zanuzo Márcio Roggia , Dallacort Rivanildo , Seabra Júnior Santino
Published: December 2022

The determined growth tomato plant has advantages such as reduction of labor and inputs, enabling the production of fruits for consumption " in natura" efficiently. The objective of this work was to evaluate the conduction and spacing systems between plants with determined tomatoes and their influence on the production attributes and quality of the fruit. The experiment was carried out in the open field with three conduction systems (“half stake”, open V and “mulch”) and four spacings between plants (0.2; 0.3; 0.4; and 0.5 m). It was found that the highest yield and commercial production and number of large fruits were obtained in the half stake and mulch system. The spacing at 0.5 m provided the highest fruit production (6.4 kg in 56 fruits), and at 0.2 m, the highest productivity was obtained (145.63 t ha -1). In the 0.2 m and open V 0.5 m stake system, the fruits had a high lycopene content. spacing 0.2 m in half stake, and mulch systems were favorable for the production of quality fruit.
Plantas medicinais com potencial aplicação em cuidados paliativos oncológicos
Authors: Medeiros Thacid Kaderah Costa , Castro Paulo Fernando Ribeiro de , Vieira Ana Cláudia de Macêdo
Published: December 2022

O Brasil possui uma farmacopeia popular muito diversa baseada em plantas medicinais e a aplicação destas no tratamento da sintomatologia de doenças avançadas e incuráveis, como nos cuidados paliativos oncológicos, podem auxiliar no tratamento preventivo ou curativo desses sintomas, proporcionando um maior conforto a esses pacientes. O presente trabalho objetiva o levantamento de dados sobre plantas medicinais com potencial aplicação no tratamento de sintomas decorrentes do câncer nos cuidados paliativos oncológicos. Realizou-se uma revisão integrativa de dados que permitam o acesso a referências sobre plantas medicinais e o cruzamento destes dados com os sintomas mais prevalentes nos cuidados paliativos oncológicos em livros de referência e em bases de dados. Foram identificadas 17 espécies vegetais com potencial uso. Como calmantes foram encontradas: capim-limão, erva-cidreira, maracujá e marcela. Espécies com ação analgésica, como adjuvantes no tratamento da dor, além das quatros espécies citadas anteriormente, temos: alecrim, boldo baiano, gengibre, babosa, calêndula e erva baleeira. Como auxiliares na cicatrização de feridas, além de alecrim, aloe e calêndula, citamos a aroeira. Dentre as espécies vegetais eficazes no tratamento de distúrbios digestivos, além de alecrim, erva-cidreira, gengibre, marcela e boldo baiano, podemos citar boldo do chile, boldo brasileiro, cáscara sagrada, erva doce, espinheira-santa e cana-do-brejo. O presente trabalho busca contribuir para o acesso da população, sejam prescritores e/ou pacientes, às informações sobre plantas medicinais com potencial aplicação nos cuidados paliativos oncológicos. Estas espécies vegetais aqui retratadas, são nativas ou facilmente cultivadas em diferentes regiões do país, o que aumenta a probabilidade do uso destes recursos terapêuticos.
Fatores estressores no ambiente acadêmico e contribuições de um programa no enfrentamento às situações de vulnerabilidade
Authors: Pereira Suellen Andrade , Pinto Fernanda Manzini , Gonçalves Luciene Resende , Oliveira Deive Ciro de , Toti Michelle Cristine da Silva , Chini Lucélia Terra , Araújo Crislaine Luisa , Bressan Vânia Regina
Published: December 2022

Objetivo: identificar fatores estressores no ambiente acadêmico e analisar as contribuições de um Programa de Extensão cuja finalidade foi auxiliar no enfrentamento às situações de vulnerabilidade dos estudantes. Método: trata-se de um estudo quantitativo, transversal e descritivo, com uma amostra de 177 estudantes de cursos de graduação da Universidade Federal de Alfenas (UNIFAL-MG). A coleta foi realizada por meio do Formulário Google, constituído por três partes: 1) Perfil sociodemográfico; 2) Fatores de estresse no ambiente universitário e; 3) Contribuições do Programa de Extensão UNIFAL Sem Estresse (PULSE) para o enfrentamento às situações de vulnerabilidade dos universitários. Resultados: a maioria (77,4%) dos respondentes possuía idade entre 18 a 24 anos e era do sexo feminino (80%). Identificou-se fontes de estresse para os estudantes, a saber: métodos de avaliação acadêmica, procrastinação em relação aos estudos, grade curricular cheia, adaptação ao novo ambiente acadêmico, dificuldades de aprendizagem, problemas de relacionamento entre docente e discente e entre colegas. Estatisticamente foi possível identificar que a contribuição da participação nas atividades do PULSE, no quesito bem-estar físico, foi maior entre as mulheres do que entre os homens. Conclusão: na perspectiva de oferecer estratégias de promoção à saúde e apoio pedagógico, conclui-se, com esse estudo, que o PULSE trouxe contribuições significativas para o enfrentamento do estresse, para a amenização dos sintomas de ansiedade e depressão, para o desenvolvimento acadêmico e cultural, melhoria do bem-estar físico e emocional, apoio pedagógico, bem como, oportunidades para a integração dos estudantes ao ambiente universitário.
Professional health, occupational stress and occupational nursing performance
Authors: Coelho Dioelen Virgínia Borges Souza de Aquino , Mueller Larissa Pires , Aquino Joshiley Coelho Guindo de , Maciel Marjorie Ester Dias , Maia Altair Meirelles de Sousa , Freitas Vinicio Guimarães , Bachega Thais Gimenes , Ferreira Tainá Damacena , Oesterreich Silvia Aparecida
Published: December 2022

Objective: To examine scientific productions that address discussions on professional health, occupational stress, and occupational nursing, highlighting ways to improve professional health so that work practice is carried out more efficiently. Methods: This is an integrative literature review built from the search in the databases: Database in Nursing - Brazilian Bibliography (BDENF), Online System for Search and Analysis of Medical Literature (MEDLINE/PUBMED), Web of Science Cochrane Library (SCOPUS) and Latin American and Caribbean Literature in Health Sciences (LILACS). Descriptors were used according to the list of Descriptors in Health Sciences (DeCS): Occupational nursing, Occupational Health, and Professional Practice. The following were included: studies with free access, available online, complete, in English/Portuguese/Spanish, and published between the years 2017 to 2022. Results: There is a correlation between occupational stress and workers' health, where job satisfaction directly interferes with their well-being. Final considerations: Occupational nursing is very important for professional health, as it has an educator and care provider role.
Benefícios da Atenção Farmacêutica no cuidado a pacientes com câncer de mama
Authors: Portela Lorena da Fonseca , Nascimento Gilvani Oliveira do , Nascimento Irlene Oliveira do , Santos Vitoria Thays Silva dos , Brito Marcelo Augusto Mota , Almeida Anne Cristine Gomes de
Published: December 2022

O câncer de mana é uma das patologias que ainda levar milhares e mulheres a óbito, ficando atras apenas do câncer do colo de útero. O diagnostico em muitas das vezes é tardio, e o tratamento acaba sendo dificultoso. Os tratamentos quimioterápicos são os que traz muitas dúvidas para a paciente. Com o intuído de amenizar tal problemática, farmacêutico é o profissional com maior capacidade e conhecimento quanto a atenção necessária para atender esse grupo. Partindo desse princípio de que é necessários mais conhecimento sobre o assunto que este trabalho teve como objetivo realizar uma revisão sistemática apontando os benefícios da atenção farmacêutica no cuidado às pacientes em tratamento com câncer de mama. Quanto a metodologia, foi usado o modelo de estudo baseado em uma abordagem qualitativa por meio de uma revisão sistemática da literatura. O método escolhido foi o de PRISMA (Preferred Reporting Items for Systematic Reviews and Metaanalyses). As pesquisas foram realizadas nas bases de dados do PubMed, BVS, MEDLINE, LILACS e SCIELO. Os trabalhos selecionados tinham o perfil de artigos originais, monografias, revistas, que tinham sido publicados entre os anos de 2015 à 2022 nos idiomas português, espanhol e inglês. Um total de 242.57 artigos foram achados nas bases de dados contudo após a aplicação dos critérios de exclusão, 10 artigos foram selecionados. Mediante aos achados, foi possível observar quão importante é a atuação do profissional farmacêutico no cuidado frente a atenção farmacêutica prestada para as pacientes com câncer de mama. Pois traz para as pacientes segurança quanto ao tratamento farmacológico, reduz dúvidas sobre medicamentos bem como a interação entre eles, diminuindo assim as dificuldades na adesão do tratamento. O farmacêutico contribui com a atenção na administração das medicações, nas dispensações das medicações, bem como nas orientações acerca do uso deles.
Tratamentos não farmacológicos para alívio da dor na assistência ao parto humanizado
Authors: Soares Maria Victoria da Silva , Lima Ellen Vitoria Ferreira dos Santos , Basílio Jaqueline Arantes Diniz , Freitas Maria da Gloria
Published: December 2022

Os tratamentos não farmacológicos são uma das alternativas mais viáveis na assistência ao parto humanizado, em virtude do custo-benefício em sua prática bem como da eficácia em seu emprego, embora pouco conhecimento de sua existência por parte das parturientes. O objetivo desse estudo é esclarecer sobre a eficácia dos tratamentos não farmacológicos na dor no parto humanizado. O método de estudo trata-se de uma revisão de pesquisa bibliográfica do tipo revisão integrativa da literatura, sendo utilizado 11 artigos científicos. Os resultados evidenciaram a eficácia na utilização do uso de técnicas como Bola Suíça, Hidroterapia, Musicoterapia, Acupuntura, Exercícios de Respiração e Aromaterapia no alívio da dor e controle emocional durante o trabalho de parto. Conclui-se que, de modo geral cada um dos métodos possui sua eficácia individualmente comprovada, mas utilizando a combinação de vários métodos trará consigo uma maior eficiência, podendo ambos serem utilizados em diferentes períodos da gestação até a concepção do feto.
The Institute of Complexity Studies and the Question of Social Responsibility
Authors: Estarque Tereza , Soreanu Raluca
Published: December 2022

This article describes the context of emergence of the Social Clinic of the Institute of Complexity Studies ( Instituto de Estudos da Complexidade, IEC) in Rio de Janeiro, Brazil, and presents the purposes and principles of the Clinic. Defined as an anti-utilitarian space, the IEC offers psychoanalysis to the economically disadvantaged. The IEC also offers elements of psychoanalytic training to disadvantaged professionals. We discuss some of the institutional processes and mechanisms of IEC, which have resulted from a collective engagement of over two decades. We also explore some important resonances between psychoanalysis and complexity thinking.
Comparison of solid and liquid fractions of pretreated Norway spruce as reductants in LPMO-supported saccharification of cellulose
Authors: Tang Chaojun , Gandla Madhavi Latha , Jönsson Leif J.
Published: December 2022

The role of lignin in enzymatic saccharification of cellulose involving lytic polysaccharide monooxygenase (LPMO) was investigated in experiments with the solid and liquid fractions of pretreated Norway spruce from a biorefinery demonstration plant using hydrothermal pretreatment and impregnation with sulfur dioxide. Pretreated biomass before and after enzymatic saccharification was characterized using HPAEC, HPLC, Py-GC/MS, 2D-HSQC NMR, FTIR, and SEM. Chemical characterization indicated that relatively harsh pretreatment conditions resulted in that the solid phase contained no or very little hemicellulose but considerable amounts of pseudo-lignin, and that the liquid phase contained a relatively high concentration (∼5 g/L) of lignin-derived phenolics. As judged from reactions continuously supplied with either air or nitrogen gas, lignin and lignin fragments from both the solid and the liquid phases efficiently served as reductants in LPMO-supported saccharification. When air was used to promote LPMO activity, the enzymatic conversion of cellulose after 72 h was 25% higher in reactions with pretreated solids and buffer, and 14% higher in reactions with pretreatment liquid and microcrystalline cellulose. Research in this area is useful for designing efficient saccharification steps in biochemical conversion of lignocellulosic biomass.
The first-line antituberculosis drugs, and their fixed-dose combination induced abnormal sperm morphology and histological lesions in the testicular cells of male mice
Authors: Bakare Adekunle A. , Moses Victoria Y. , Beckely Charles T. , Oluyemi Toluwani I. , Ogunfeitimi Gift O. , Adelaja Aduragbemi A. , Ayorinde Glory T. , Gbadebo Adeyinka M. , Fagbenro Olukunle S. , Ogunsuyi Olusegun I. , Ogunsuyi Opeoluwa M. , Ige Olusoji Mayowa
Published: December 2022

Rifampicin (RIF), Isoniazid (INH), Ethambutol (EMB), Pyrazinamide (PZA), and/or their fixed-dose combination (FDC) are extensively prescribed in the cure of Tuberculosis (TB) globally. In spite of the beneficial effect, these drugs are capable of inducing cellular toxicity. Existing information on the genotoxic effects of the first-line anti-TB drugs is limited and contentious. Herein, we evaluated the reproductive genotoxicity of RIF, INH, EMB, PZA, and their FDC utilizing the mouse sperm morphology assay. Histological examination of the testes of exposed mice was also performed. Male Swiss albino mice (11–13 weeks old) were intraperitoneally exposed for 5 consecutive days to each of the anti-TB drugs at four different doses of 6.25, 12.5, 25, and 50 mg/kg bw of PZA; 2.5, 5.0, 10, and 20 mg/kg bw of RIF; 1.25, 2.5, 5.0 and 10 mg/kg bw of INH; 3.75, 7.5, 15 and 30 mg/kg bw of EMB; and 7, 14, 28 and 56 mg/kg bw of FDC corresponding respectively to ×0.25, ×0.5, ×1 and ×2.0 of the standard daily dose. In comparison with the negative control (normal saline), there was no significant difference in the testicular weight and organo-somatic index of exposed mice. There was an increase (p> 0.05) in the frequency of abnormal spermatozoa at most of the tested doses of each drug and a dose-dependent decrease with the FDC. Each of the anti-TB drugs except the FDC induced pathological lesions in the testes. These findings suggest that the individual first-line anti-TB drug unlike the FDC has the potential to provoke testicular anomalies in male mice.
Comparison of the enzymatic depolymerization of polyethylene terephthalate and AkestraTM using Humicola insolens cutinase
Authors: Aristizábal-Lanza Lucía , Mankar Smita V. , Tullberg Cecilia , Zhang Baozhong , Linares-Pastén Javier A.
Published: December 2022

The enzymatic depolymerization of synthetic polyesters has become of great interest in recycling plastics. Most of the research in this area focuses on the depolymerization of polyethylene terephthalate (PET) due to its widespread use in various applications. However, the enzymatic activity on other commercial polyesters is less frequently investigated. Therefore, AkestraTM attracted our attention, which is a copolymer derived from PET with a partially biobased spirocyclic acetal structure. In this study, the activity of Humicola insolens cutinase (HiCut) on PET and AkestraTM films and powder was investigated. HiCut showed higher depolymerization activity on amorphous PET films than on Akestra™ films. However, an outstanding performance was achieved on AkestraTM powder, reaching 38% depolymerization in 235h, while only 12% for PET powder. These results are consistent with the dependence of the enzymes on the crystallinity of the polymer since Akestra™ is amorphous while the PET powder has 14% crystallinity. On the other hand, HiCut docking studies and molecular dynamic simulations (MD) suggested that the PET-derived mono (hydroxyethyl)terephthalate dimer (MHET)2 is a hydrolyzable ligand, producing terephthalic acid (TPA), while the Akestra™-derived TPA-spiroglycol ester is not, which is consistent with the depolymerization products determined experimentally. MD studies also suggest ligand-induced local conformational changes in the active site.
Numerical analysis of the energy-storage performance of a PCM-based triplex-tube containment system equipped with arc-shaped fins
Authors: Abed Azher M. , Mouziraji Hosseinali Ramezani , Bakhshi Jafar , Dulaimi Anmar , Mohammed Hayder I. , Ibrahem Raed Khalid , Ben Khedher Nidhal , Yaïci Wahiba , Mahdi Jasim M.
Published: December 2022

This study numerically intends to evaluate the effects of arc-shaped fins on the melting capability of a triplex-tube confinement system filled with phase-change materials (PCMs). In contrast to situations with no fins, where PCM exhibits relatively poor heat response, in this study, the thermal performance is modified using novel arc-shaped fins with various circular angles and orientations compared with traditional rectangular fins. Several inline and staggered layouts are also assessed to maximize the fin’s efficacy. The effect of the nearby natural convection is further investigated by adding a fin to the bottom of the heat-storage domain. Additionally, the Reynolds number and temperature of the heat-transfer fluid (HTF) are evaluated. The outcomes showed that the arc-shaped fins could greatly enhance the PCMs’ melting rate and the associated heat-storage properties. The melting rate is 17% and 93.1% greater for the case fitted with an inline distribution of the fins with a circular angle of 90° and an upward direction, respectively, than the cases with uniform rectangular fins and no fins, which corresponded to the shorter melting time of 14.5% and 50.4%. For the case with arc-shaped fins with a 90° circular angle, the melting rate increases by 9% using a staggered distribution. Compared to the staggered fin distribution, adding an extra fin to the bottom of the domain indicates adverse effects. The charging time reduces by 5.8% and 9.2% when the Reynolds number (Re) rises from 500 to 1000 and 1500, respectively, while the heat-storage rate increases by 6.3% and 10.3%. When the fluid inlet temperature is 55°C or 50°C, compared with 45°C, the overall charging time increases by 98% and 47%, respectively.