bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Impurity Elements in Recycled Ingots on Seizure Properties of Die-Cast Cylinders made of Hypereutectic Al-Si Alloy
Authors: Owada Atsushi , Suzuki Takaharu
Published: October 2023

In recent years, efforts to reduce CO2 emissions (carbon neutrality) have accelerated worldwide. In the aluminum manufacturing industry, CO2 emissions can be reduced by switching the raw materials of choice; from virgin ingots to recycled ingots. However, the possible characteristic change accompanying the usage of impurity-ridden recycled ingots severely limits its applications, which also limits its potential contribution to carbon neutrality. Determining how impurity elements present in recycled ingots can affect the function of manufactured components is a necessary first step towards expanding the usage of recycled ingots.

In this study, we aimed to apply recycled ingots to the monolithic cylinder made of hypereutectic Al-Si alloy and investigated how impurity elements in recycled ingots affect properties (especially seizure characteristic).

Die-cast cylinders using virgin and recycled ingots were manufactured and their properties were investigated. The elements that increased in the recycled ingots were Zn, Mn, and Ni. The effects of these elements on the seizure resistance were confirmed by reciprocating sliding test. In addition, we confirmed the differences in the compounds formed from metallographic observations and discussed the relationship between these compounds and seizure resistance using thermodynamic calculation software (Thermo-calc), among other methods.
Development of Method for Improvement Motorcycle Frame Accuracy by Utilizing Weld Distortion Visualization Technology and Expert Knowledge and Thinking
Authors: MATSUMOTO YOJI , Kobayashi Hiroaki
Published: October 2023

Dimensional error during mass production of motorcycle frames are considered to be the accumulation of large deformations (welding distortions) generated by arc welding in each process. In order to satisfy the dimensions of the product, it is necessary to individually grasp the welding distortion generated in each process as a change in the three-dimensional shape, and to adjust the individual three-dimensional behavior of the entire welding line to converge within the tolerance range.

However, it is a method in which one expert figure out the shape changes at intermediate process in his mind from hole position information of the final product and determines the adjustment amount of jigs and parts in each process.

In response to this problem, we have developed a technology to calculate the relative deviation of pre-welded and post-welded parts for each component from pre- and post-weld shape measurement data and CAD data, and to decompose the shape changes that occur before and after welding into “deformation” and “displacement”.

With this technology, it became possible to obtain information on shape changes due to welding, which is the most important for improving accuracy, and it became possible to make accuracy adjustments while tracking three-dimensional changes in the frame shape due to welding.

In addition, we were able to draw out the knowledge and thoughts of experts while reading information on shape changes in each process, and the entire team was able to grasp the welding behavior and shift to a business process that takes countermeasures.

As a result, experts and young engineers became one team, and We were able to achieve the required dimensional accuracy in the production prototype, which also led to the development of young engineers. In this report, we will introduce the new business process that is the key with specific examples.
Development of Supercharged Two-Stroke Engine with Intake and Exhaust Valve for Hybrid System
Authors: Hisano Atsushi , Saitou Masahito , Sakurai Yota , Matsuda Yoshimoto , ichi Satoaki
Published: October 2023

The two-stroke engine has a small displacement and high output, and therefore saves space when the engine is installed in a vehicle. Thus, the application of two-stroke engines to HEVs is a very effective means of reducing vehicle weight and securing engine space. On the other hand, the unfired element increases in the exhaust gas with a two-stroke engine because the air-fuel mixture is blown through to the exhaust system during the scavenging process inside the cylinder. Moreover, combustion becomes unstable due to the large amount of residual burnt gas in the cylinder. To solve these problems, we propose a two-stroke engine that has intake and exhaust valves that injects fuel directly into the cylinder. We describe the engine shape and the method that can provide high scavenging efficiency and stable combustion in such a two-stroke engine.
Simulation Study on the Effect of In-Cylinder Water Injection Mass on
Engine Combustion and Emissions Characteristics
Authors: Guan Jun , Shang Quanbo , Hu Yinuo , Lu Ye , Li Liguang , Deng Jun
Published: October 2023

The rapid development of the automobile industry has brought energy and
environmental issues that scholars are increasingly concerning about. Improving
efficiency and reducing emissions are currently two hot topics in the internal
combustion engine industry. Direct water injection technology (DWI) can
effectively reduce the cylinder temperature, which is due to the absorption of
the heat by the injecting liquid water. In addition, lower temperature in the
cylinder will reduce the formation of NO. In this paper, a CFD simulation of DWI
application in a lean-burning single-cylinder engine with pre-chamber jet
ignition was carried out. And the engine was experimentally tested for the
simulation model validation. And then the effect of DWI strategy with different
injecting water mass on the combustion and emissions characteristics are
analyzed. Physically, injected water not only absorbs heat but also provides
heat insulation. The results are shown under the rotating speed of 2800 r/min
and IMEP of 11.5 bar, without changing the ignition advance angle. A small
amount of water, with almost constant cylinder temperature, dissociates into
more OH and H, which may promote combustion and improve the thermal efficiency
combined with heat insulation effect. An appropriate amount of water plays a
dominant role in heat absorption, resulting in decrease of temperature
in-cylinder. NO emission will significantly reduce under the water mass is 5mg
and the injection timing is -150°CA ATDC. The ITE decreases by 3.3% while the NO
emission decreases by about 80%. Excessive water significantly reduces cylinder
temperature, leading to unstable combustion and even flameout. It may cause
insufficient combustion and reduce the ITE of the engine.
Optimization of Microporous Layer Composition at Varying Humidities
for High-Performance Polymer Exchange Membrane Fuel Cell
Authors: Lou Mingyu , Lin Rui , Chen Liang
Published: October 2023

Proton exchange membrane fuel cell (PEMFC) is a promising energy supply device.
Its improvement on output performance has always been a main subject.
Microporous layer (MPL) is the water management center of PEMFC, which has an
important influence on the mass transfer process and performance of PEMFC under
high current density. In this paper, the performance of GDL based on Toray-H-060
with different carbon powder and C:PTFE of MPL were tested and optimized. SEM
and static contact Angle was used to investigate Characterization of GDLs. The
polarization curve was used to select the best performance, and EIS was used to
explore the internal optimization mechanism. The output performance increases
with humidity from 25%RH to 75%RH for all four samples. The MPL sample
formulated with C: PTFE = 8:2 and XC-72 powder is the best under wide humidity
region, and the best performance is achieved at 75%RH. The maximum power density
reaches 0.949W/cm2 at 1.8A/cm2. At 100%RH, because of
dense structure, the GDL of Toray substrate has poor output performance and low
maximum power density of PEMFC, because of cathode flooding under high humidity
conditions. The increasement of MPL hydrophobicity, achieved by change of carbon
powder and PTFE content, contributes to the decrement of mass transfer
resistance at high current density. The equilibrium between proton conductivity
and water management is essential to ensure improved fuel cell performance. In
summary, this study is useful for understanding influence of MPL contents on
mass transfer performance in PEMFC and can guide the composition design of
MPL.
Research on Injection Characteristics of Marine Ammonia Fuel Injector
under Wide Temperature Range
Authors: Li Meisi , Fan Liyun , Wei Yunpeng , Mao Yuntao
Published: October 2023

Ammonia fuel is typically characterized by low viscosity, low flash point, and
non-flammability. This means that fuel characteristics and operational
requirements significantly deviate from those of conventional fuels, requiring a
significant technical upgrade to the existing fuel supply and injection systems.
This research involves a numerical analysis of ammonia utilization in
high-pressure direct injection. Considering the non-isothermal compressibility
of the fuel flow process, the fluid properties in the model are specifically
defined based on the physical properties of the ammonia fuel. The injection
performance of ammonia fuel was studied, including comparing the injection
performance of ammonia fuel with conventional diesel fuel under typical
operating conditions in the injector, and exploring the injection
characteristics of ammonia fuel injector under a wide fuel temperature range.
The results of ammonia injection indicate that the response characteristics of
liquid ammonia and diesel are slightly different. In terms of pressure
characteristics, the pressure fluctuation of liquid ammonia is significantly
smaller than that of diesel, and the fluctuation is more uniform. As for
temperature characteristics, the liquid ammonia oil chamber has a lower
temperature than the diesel oil chamber and reaches a stable state faster. In
addition, the operating conditions of the engine are prone to changes in the
phase state of ammonia fuel. The transition from liquid to supercritical state
of ammonia fuel at various temperatures and pressures reveals the corresponding
relationship between the phase transition zone of ammonia fuel and fuel
injection characteristics.
An Operating Point Adjustment Model Using PMP-GWO-Bi-LSTM for RANGE
Extended Electric Vehicle
Authors: Huang Wei , Zhang Yujun , Qian Duode , Hu Biqian
Published: October 2023

The increasingly severe energy problems and environmental pollution have imposed
severe requirements on the fuel saving level of vehicles. The range extender
configuration is a tandem structure that has attracted more and more
researchers’ attention due to its architectural features and control methods. An
intelligent APU operating point adjustment model based on PMP-GWO-Bi-LSTM is
proposed in this paper to enhance adaptability to real driving conditions for
the traditional optimal strategy. Firstly, a PMP model has been applied into a
range extended electric vehicle model from which the optimized power
distribution data under several standard driving cycles was recorded as the
input to deep learning model. Secondly, a Bi-LSTM model fed by control
parameters and power distribution data was established and trained using
aforementioned datasets. The aim is to learning the nonlinear regression
relationship model between APU control variables and power distribution.
Furthermore, the GWO optimization algorithm is introduced to optimize the
hyperparameter of Bi-LSTM to speed up the running speed of the model and improve
accuracy. Finally, the experiment was conducted using real driving condition
data to predict the power distributions. The simulation results show APU overall
efficiency improvement by 15.87% whilst fuel consumption improved by 9.42%. The
number of hyper parameters such as the iterations and hidden layer units using
GWO optimization algorithm is 35.50% and 38.38% less and the training time
decreases by 4.61 s, which proves that the model proposed in this paper can
achieve good result in real driving conditions.
LES Study of the Mixing Process and Cyclic Variation of a
Direct-Injection Hydrogen Engine
Authors: Liu Xiaoqi , Han Zhiyu
Published: October 2023

Hydrogen internal combustion engine is considered to be one of the promising ways
to achieve zero-carbon emissions in the automotive industry. However, the
problem of high NOx emissions from hydrogen engines needs to be
addressed. Although homogeneous lean-mixture combustion could reduce engine-out
NOx emissions, it is necessary to ensure mixing homogeneity to
avoid excessive NOx formation from the rich mixture packets. In this
study, large-eddy simulations (LES) of a direct-injection hydrogen engine were
carried out to assess the hydrogen-air mixing process in forming homogeneous
charges with consideration of cyclic variations. The high-speed hydrogen jet
flow was modeled in a constant-volume vessel first to verify the LES model.
Engine simulations were then performed to study the effects of the injector
location (side vs. central), injection pressure, and injector type (pintle vs.
outward opening) on the mixing process, mixture homogeneity, and cyclic
variations. The results show that the mixture homogeneity and its cyclic
variations are influenced by these parameters, and the centrally located pintle
injector with an injection pressure of 10 MPa can produce the best mixture
homogeneity and minimal cyclic variations among the cases
studied.
Improving Healthcare Providers’ Adherence to Foot Exams for Type-II Diabetic Patients in a Primary Care Clinic
Authors:   Department of Community, Systems, and Mental Health Nursing, Rush University College of Nursing, 600 S. Paulina St. #1080, Chicago, Allen Angela
Published: October 2023

Foot wounds are complications of type II diabetes mellitus (T2DM), which may be prevented with proper foot assessments. Diabetic foot exams are not consistently performed despite evidence-based screening tools available. Objective: To determine if the implementation of an electronic medical record (EMR) alert using Inlow’s 60-Second Diabetic Foot Screen would impact the number of diabetic foot exams performed among T2DM patients at a primary care level. Method: A quantitative quasi-experiment design was used to implement an electronic medical record (EMR) alert using Inlow’s 60-Second Diabetic Foot Screen to impact the frequencies of diabetic foot exams. Sample size was 65, n=35 in the comparative group and n= 30 in the implementation group. Population consisted of male and female patients ages 18 years and older, diagnosed with T2DM within the last two years, no previous diabetic foot exams or received foot care education, did not perform self-reported foot inspections, and were able to read, write, and speak English. A chi square test was run to analyze the frequencies of foot exams between groups. Results: A Pearson’s chi-square showed a statistically significant increase in the foot exams X2 (1, N=65) = 5.286, p= 0.02 using an EMR alert with Inlow’s 60-Second Diabetic Foot screen. Conclusion: EMR alerts increase performance of diabetic foot exams. Recommendations include sustainment of the program, dissemination of results, and further investigation of the impact of EMR alerts. Keywords: Diabetes, Foot screening, EMR alert
Is There Any Relation Between High-Grade Prostate Cancer and Central Obesity, Hyperinsulinemia and Dyslipidemia?
Authors:   Department of Urology, MGM Medical College, Indore, Madhya Pradesh, India, Jain Vishal Kirti , Agrawal Madan Mohan , Yadav Sher Singh , Agarwal Neeraj
Published: October 2023

Background: Prostate Cancer (PCa) is the sixth leading cause of cancer death in men, worldwide. Incidence of prostate cancer in India is on the rise. Most studies suggest that obesity has a positive correlation with a higher risk of developing high-grade PCa and dying of PCa. Central obesity and related biochemical alterations in terms of hyperinsulinemia and dyslipidemia are associated with severity of prostate cancer in terms of high Gleason score. Materials & Methods: Central obesity was assessed using anthropometric measurements including waist hip ratio (WHR) and body mass index (BMI). Serum PSA, testosterone, and insulin levels were estimated. Serum levels of triglycerides (TG), cholesterol, low-density lipoprotein (LDL), and very low-density lipoprotein (VLDL), high-density lipoprotein (HDL) were also measured. Standard staging procedures were followed and for histopathological evaluation of PCa, Gleason grading was done on core biopsy tissue. Results: In the present population-based study, persons with high Gleason score had significantly higher WHR supporting that central obesity may predispose to high-grade prostate cancer. Study has shown a significant relationship between high Gleason score and cholesterol, TG, VLDL, and low HDL levels; however no significant relation was found with LDL levels. Testosterone is a key prostate growth factor although PCa presents at an age when testosterone levels are declining. Conclusion: In this study, there was no significant difference in testosterone levels in patients with high and low Gleason scores. Keywords: Prostate, Cancer, High grade, Low grade
Comparison of Maternal and Foetal Outcome between Normal and Abnormal Amniotic Fluid Index in the Third Trimester of Pregnancy - A Longitudinal Analytical Study in A Tertiary Level Medical College of Suburban West Bengal, India
Authors:   College of Medicine & JNM Hospital, Kalyani, Nadia, India, Bera Gairik , Burman Sougata Kumar , Maji Mousumi , Mukherjee Jayeeta , Talukder Anirban , Pal Manidip
Published: October 2023

Background: Amniotic fluid (AF) is the protective liquid present in the amniotic sac of a gravid uterus. Amniotic fluid has nutritive, protective and diagnostic functions. Amniotic Fluid Index (AFI) is most popular and reliable method for quantifying amniotic fluid, till date. AFI is one of the major parameters of foetal biophysical profile (BPP) that can predict perinatal and maternal outcomes. Periodical scanning of foetus is utmost essential during antenatal visits, especially in high-risk pregnancies, but there is no definite standard protocol regarding its frequency.Methods: This study was conducted in the department of Obstetrics & Gynaecology, College of Medicine & JNM Hospital, Kalyani, Nadia, India. This longitudinal analytical study included 356 patients, among whom 151 (42.4%) were in oligohydramnios group, 174 (48.9%) in normal group and 31 (8.7%) in polyhydramnios group.Results: The data revealed oligohydramnios was strongly associated with caesarean section (p = 0.0010). In oligohydramnios group, IUGR was found in 37 (24.5%) patients (p = 0.0297). Meconium-stained liquor was almost similar in all three categories i.e. 15 (10.0%) in oligohydramnios group, 18 (10.3%) in normal group and 5 (16.1%) in polyhydramnios group, respectively. There was higher SNCU admission among babies delivered by mothers with oligohydramnios (p = 0.0369). There was no statistically significant difference in 1 and 5 minutes APGAR scores among normal and abnormal AFI groups. Conclusions: It was inferred that LSCS, IUGR baby and SNCU admission rates were more in oligohydramnios group compared to other categories. The perinatal death was 3.3% with oligohydramnios compared to 1.7% with normal liqour. The results from this study emphasize on the importance of AFI among the various means of antepartum surveillance and predictors of foetal outcome. Keywords: Oligohydramnios, Polyhydramnios, Foetal Outcome, IUGR, AFI
Concordance Between Core Needle Biopsy and Surgical Specimens in Determining Molecular Biological Subtypes of Breast Cancer by Immunohistochemistry
Authors:   Department of Pathology, Murshidabad Medical College & Hospital, Berhampore, 742101, West Bengal, India, Dutta Oisika , Chowdhury Anadi Roy , Sarkar Niladri , Ghosh Suman
Published: October 2023

Background: Breast carcinoma is the most common malignancy among women around the world. Core needle biopsy provides samples that are adequate in size thus allowing a histological diagnosis of breast carcinomas. CNB specimens can also be used for the immunohistochemical (IHC) assays of hormone receptors. Aims: To evaluate the concordance of ER, PR, HER2 Neu and Ki-67 in core needle biopsy and surgical specimens obtained by Modified radical mastectomy (MRM). Methods: A cross-sectional observational study was conducted in the Department of Pathology in association with the Department of Surgery at Murshidabad Medical College and Hospital for a duration of one and a half years. Patients undergoing Core needle biopsy of the breast who have been diagnosed with breast carcinoma on the basis of histopathology report and subsequently planned for MRM who have given consent for the study were included in this study. The samples were classified according to the immunohistochemical staining into four molecular subtypes: Luminal A, Luminal B, HER 2 Neu enriched, and triple-negative subtype depending on the expression of ER, PR, HER 2 Neu, and Ki-67. Result: The most common molecular subtype of breast carcinoma in both CNB and MRM specimens was the Triple-negative subtype. Conclusion: CNB has been found to be a reliable diagnostic tool that can help in determining Histopathological biomarkers for ER, PR positive, and HER2 Neu positive or negative tumors and it has also been found that retesting these markers again on the surgical specimens may not be necessary. Keywords: Core needle biopsy, Breast carcinoma, Molecular subtyping, Immunohistochemistry
Application of FOB (Free on Board) Incoterms 2020 in Export Activities of Processed Coconut Products
Authors: Rakhman Rizqi Aini , Sianturi Intan , Amrullah Romanda Annas
Published: October 2023

Export activities in Indonesia are a major factor in the country's economic growth. In 2022, Cumulatively, Indonesia's export value reached US$291.98 billion, up 26.07 percent compared to 2021. Meanwhile, non-oil and gas exports reached US$275.96 billion, an increase of 25.80 percent, so export activities in Indonesia are still a significant factor in the country's economic growth. To regulate export activities that use sea transportation, exporters and importers must pay attention to the trade agreement contained in the International Commercial Terms (Incoterms) 2020; one of the terms is Free on Board (FOB). This study aims to find out how the value of FOB terms is more in the export of goods, especially in processed coconut products. The research method is descriptive qualitative with a structured interview method questionnaire with a rating scale method. The results of the study show that for exporting companies engaged in processed coconut products, FOB terms are most often used with an interval value of 37/40, or in another sense, FOB terms are the most frequently used terms in processed coconut product exporting companies. The advantage of using the FOB term for exporters is that they have responsibility until the cargo arrives on the ship and do not bear shipping costs, so freight fluctuations are avoided. It is the safest for exporters because importers must first open a Letter of Credit (L/C) as collateral and basis for export activities.
Virtual Lab Simulator in Mechanical Engineering Education-Hybrid Approach
Authors: Gali Singaiah , Buyyani Pavani , Kowdodi Siva Prasad , Chepuri Sai Abhinav
Published: October 2023

Many universities worldwide are partially disrupting their education by the spread of the coronavirus. Consequently, the Universities took the necessary steps to change their teaching methods to online laboratory experiments and workshops. However, universities should continue to maintain their higher education standards and provide a high-quality student experience required for the learning outcomes associated with each degree program. Adhering to online teaching methods for both theory and practical lectures has created a challenge in education. The discussion of the theory lessons by showing PPTs and video presentations was comfortable for students. In addition to that, virtual labs came into existence. These virtual labs had a significant impact on students' learning process, but this did not apply to all labs. This paper projects the outcome of the virtual lab using the explicit dynamic analysis application in solid works software and integration of AR & VR teaching techniques. This paper also includes the work done by the students and the effective outcome utilization of virtual labs compared with practical labs by using mild steel specimens.
Risk assessment to support guidance for norovirus outbreaks in oysters
Authors: Evans Charlotte , Hargreaves Jacob , Cohen Victoria , Gherman Iulia
Published: October 2023

This assessment has been commissioned in response to recurring outbreaks of norovirus linked to the consumption of raw oysters. Each outbreak requires food safety and health protection resource to manage, as well as having a direct and indirect impact on consumers and on businesses involved, and further guidance has been requested to deal with norovirus outbreaks.
Molecular docking study of designed N-myristoyl transferase inhibitors
Authors:   University of Kragujevac, Faculty of Medical Sciences, Serbia, Gogić Anđela D. , Vesović Marina Ž. ,   University of Kragujevac, Faculty of Medical Sciences, Serbia, Nikolić Miloš V. ,   University of Kragujevac, Faculty of Medical Sciences, Serbia, Bukonjić Andriana M. ,   University of Kragujevac, Faculty of Medical Sciences, Serbia, Tomović Dušan Lj. ,   University of Kragujevac, Faculty of Medical Sciences, Serbia, Nedeljković Nikola V. ,   University of Kragujevac, Faculty of Medical Sciences, Serbia
Published: October 2023

N-myristoyl transferase has a key role in the myristoylation of vital proteins and is necessary for the growth and synthesis of material for the survival of various fungi. Due to the difference in the structure of fungal and mammalian N-myristoyl transferase, the crystal structure of the N-myristoyl transferase originating from Candida albicans was used as the target molecule. The present in silico study aims to design compounds, benzofuran derivatives, and simulate the interactions of the compounds and the amino acid sequences of the active center N-myristoyl transferases from Candida albicans using the molecular docking method. The highest number of significant binding interactions is realized by the derivative 4. Affinity toward the N-myristoyl transferase active site was very similar to the co-crystallized ligand, and important hydrogen interactions were retained. Based on the obtained results of molecular docking, it can be concluded that derivative 4 has the potential to inhibit N-myristoyl transferase, on which future research of its antifungal activity can be based.
In silico antibiofilm potency of phenolic N-acyl hydrazones against selected bacterial strains
Authors:   University of Kragujevac, Faculty of Science, Serbia, Branković Jovica , Petrović Zorica D ,   University of Kragujevac, Faculty of Science, Serbia, Petrović Vladimir P. ,   University of Kragujevac, Faculty of Science, Serbia
Published: October 2023

In the present work, fourteen phenolic hydrazone derivatives were evaluated for their in silico inhibitory activity against selected P. aeruginosa and S. maltophilia proteins involved in drug resistance and biofilm formation. Molecular docking analysis revealed the highest binding affinity of analogs n (-8.4 kcal/mol) and h (-7.3 kcal/mol) towards P. aeruginosa 7m1m and 7m1l proteins, respectively. In the case of S. maltophilia, analog k (-8.4 kcal/mol) expressed the highest binding affinity to 6qw7, whereas for 6uaf, the lowest binding energy was calculated for derivative d (-8.1 kcal/mol). The obtained in silico results highlight the potential inhibition potency of the selected hydrazone analogs against investigated proteins and represent a good basis for future in vitro antibiofilm investigations.
Synthesis and cytotoxic activity of selected dual COX-2 and 5-LOX inhibitors in HeLa and MIA PaCa-2 human cancer cell lines
Authors:   University of Belgrade, Vinča Institute of Nuclear Sciences - National Institute of the Republic of Serbia, Department of Molecular Biology and Endocrinology, Keta Otilija , Bošković Jelena ,   University of Belgrade, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Serbia, Petković Vladana ,   University of Belgrade, Vinča Institute of Nuclear Sciences - National Institute of the Republic of Serbia, Department of Molecular Biology and Endocrinology, Đorđević Neda ,   University of Belgrade, Vinča Institute of Nuclear Sciences - National Institute of the Republic of Serbia, Department of Molecular Biology and Endocrinology, Dobričić Vladimir ,   University of Belgrade, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Serbia, Čudina Olivera ,   University of Belgrade, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Serbia, Pajović Snežana B. ,   University of Belgrade, Vinča Institute of Nuclear Sciences - National Institute of the Republic of Serbia, Department of Molecular Biology and Endocrinology
Published: October 2023

Among novel cancer chemotherapy approaches, the use of cyclooxygenases (COXs) and lipoxygenases (LOXs) inhibitors represents a promising mean for cancer treatment showing lesser toxicity comparing to the currently used cytotoxic drugs. This study detailed the synthesis of three novel compounds: 1ME, BHTK-AA, and IBU-Ac, each with the capability to concurrently inhibit both COX-2 and 5-LOX. Subsequently, we assessed their effectiveness in inhibiting the proliferation of HeLa cervical and MIA PaCa-2 pancreatic cancer cells. The IC50 values for both examined cell lines were approximately 40 μM, indicating the promising inhibitory potential of the IBU-Ac compound in both types of cancer cells. This finding is positioned to stimulate further investigation into the potential application of IBU-Ac against these particular types of cancers, while also advocating its use in combination with standard anti-cancer protocols, i.e., chemoterapeutics or radiation therapy. The results of this work are also advocating the development and refinement of dual COX-2 and 5-LOX inhibitors, thus improving their efficacy and safety.
Synthesis, characterization and HSA interactions of a new piano-stool ruthenium(II) complex containing a thioamide-type ligand
Authors:   University of Kragujevac, Institute for Information Technologies, Serbia, Stojković Danijela , Đukić Maja ,   University of Kragujevac, Faculty of Science, Serbia, Ristić Marija ,   University of Kragujevac, Faculty of Science, Serbia, Ćendić Serafinović Marina ,   University of Kragujevac, Faculty of Science, Serbia, Belošević Svetlana ,   University of Priština in Kosovska Mitrovica, Faculty of Technical Sciences, Serbia, Mrkalić Emina ,   University of Kragujevac, Institute for Information Technologies, Serbia, Jakovljević Ivan ,   University of Kragujevac, Faculty of Science, Serbia
Published: October 2023

The synthesis and characterization of a newly synthesized piano-stool [Ru-(ɳ6-p-cymene)Cl2L] complex with a ligand 3-amino-2-cyano-N-phenyl-3-(4-phenyl-1-piperazinyl)-2-propenethioamide are presented. The complex was obtained in good yield as an ochre powderand was characterized by elemental analysis, 1H and 13C NMR, IR, conductometry, and melting point. The fluorescence binding studies showed that the interaction of the complex with albumin occurs by a static quenching mechanism and that the complex showed a very high value of the binding constant with one binding site (Kb = 1.68 × 107; n = 1.37). In order to identify the binding location in the HSA molecule, competitive experiments with site markers (eosin Y (site I) and ibuprofen (site II)) were performed. Obtained results showed that the examined complex binds to the site I of subdomain IIA (for eosin Y: Kb = 5.94 × 102; n = 0.65 vs. for ibuprofen: Kb = 1.38 × 107; n= 1.34).
Preduzetničke kompetencije vaspitača u kontekstu profesionalnog osposobljavanja
Authors:   University of Kragujevac, Faculty of Technical Sciences, Čačak, Bjekić Dragana , Zlatić Lidija ,   University of Kragujevac, Faculty of Education in Užice
Published: October 2023

Whether entrepreneurship competences are considered as competences of the entrepreneur's professional action (career determination) or general transferable competences necessary for the action of every person (competence components of functional action), their development has its basis in childhood. Therefore, supporting the development of entrepreneurship characteristics in children during preschool education is necessary. The first systematic education of preschool children is realized by preschool teachers. The importance of preschool educators for the development of entrepreneurship competencies in preschool children is discussed in the paper. The specifics of the entrepreneurship competence of preschool educators, who should act as models to develop the entrepreneurship competencies of their preschool pupils/children, are also presented. A holistic approach to the entrepreneurship training of educators is proposed to develop their entrepreneurship competencies and to develop methods and approaches for the entrepreneurship education of preschool children.
Zastupljenost muzičkih predmeta na fakultetima za obrazovanje vaspitača u Republici Srbiji i regionu
Authors:   University of Kragujevac, Faculty of Education in Užice, Sudzilovski Danijela M. , Tanasković Marija K. ,   University of Kragujevac, Faculty of Education in Užice
Published: October 2023

The paper deals with music education of students, future educators at the initial level. The subject of the conducted research arestudy programs of the faculties where educators are trained in the Republic of Serbia, Bosnia and Herzegovina, Slovenia, Montenegro, North Macedonia and Croatia. The goal of the research is a comparative analysis of study programs of the faculties where educators are trained, specifically, an analysis of the representation of music subjects that enable students to acquire competencies for the realization of musical activities. The focus was on compulsory and optional subjects within the musical education of students. The sample consisted of the programs of 17 faculties in the Republic of Serbia and the region.The comparative analysis showed that music subjects are incorporated differently in the programs. A smaller difference was observed in the treatment of compulsory subjects, while a greater distinction is evident in optional subjects. Bearing in mind the importance of the initial education of educators for future work with children, we believe that in the creation of study programs for the education of educators, it is necessary to devote more attention and space to music subjects, so that the musical education of students is continuous during their studies.
Književnim tekstom pobediti strah – dečji strahovi u poeziji i prozi Dušana Radovića
Authors:   University of Kragujevac, Faculty of Education in Užice, Kostić Ljiljana
Published: October 2023

Dušan Radović’s children’s oeuvre was based on his partnership with his little recipients. Showing understanding for children’s position and their problems, he treated them as his equals, by supporting, encouraging and educating them. Aware of the fact that a children’s poet must be wise so as to be able to teach them something and have them trust him, he revealed the truths of life to them as well as the things they were not familiar with. A significant place in Radović’s oeuvre was occupied by the problem of childhood fears and the ways of overcoming them. The paper deals with Radović’s literary texts in which various childhood fears are thematized and also with the ways of using these texts in the context of overcoming prschoolers’ fears.
Imenice motivisane rečima „DETE“ i „DZIECKO“ u srpskom i poljskom jeziku
Authors:   Uniwersytet Śląski w Katowicach, Faculty of Humanities, Republic of Poland, Bońkowski Robert
Published: October 2023

The paper discusses nouns directly motivated by the Serbian word дете (i.e. the collective noun деца) and the Polish word dziecko (i.e. dziecię) in the two languages. Particular attention was paid to the definition and the etymology of these source words, as well as the derivational possibilities of the numerous noun derivations found in Serbian and Polish. The analysis carried out in this way can also serve as a didactic aid in the study of Serbian as a foreign language for Polish students of Serbian Studies and Serbian students of Polish Studies.
The Importance of Rhythmic-Movement Games for Hearing-Impaired Children in Pre-Primary Education
Authors:   Constantine the Philosopher University, Faculty of Education, Nitra, Slovakia, Hubinská Zuzana , Tunegová Liliana ,   Constantine the Philosopher University, Faculty of Education, Nitra, Slovakia
Published: October 2023

Healthy people can hardly imagine the hearing impairment in everyday life and in the most cases, they do not encounter it. Itʼs not easy to imagine life in silence or in partial silence, when a hearing-impaired person, a child, does not perceive or perceives the sounds around themselves only weakly. The present paper deals with the educational process of children with hearing impairment. It briefly introduces hearing impairment, pre-primary education of hearing-impaired children in Slovakia and the place of rhythmic and movement education in the State Educational Programme. The paper also includes specific rhythmic and movement activities applicable in the educational process at the primary level of education.
PENGEMBANGAN SISTEM INFORMASI UNTUK ADMINISTRASI LAYANAN SURAT DI KELURAHAN BUMIAJI
Authors:   Universitas Muhammadiyah Surakarta, Amalia Suci Cahya , Nugroho Yusuf Sulistyo
Published: October 2023

One of the various types of written communication tools is a letter, which is divided into official letters and non-official letters. Official letters are used for formal purposes. However, the process of letter administration in Kelurahan Bumiaji, Kabupaten Sragen is still done conventionally, where people who need a letter have to come to the Kelurahan office and queue, which makes the process ineffective. The letter archiving process carried out by the Kelurahan office is also poorly organized. To overcome this problem, in this study, an information system for letter service administration based on a website was created for the Kelurahan Bumiaji office. The method used to develop the system is the software development life cycle (SDLC), with a waterfall process model. The result of this research is the creation of an information system that can assist the community in obtaining the letters needed and assisting in mail services by the Kelurahan Bumiaji. In addition, this information system also displays information such as announcements from Kelurahan and assets owned by the Kelurahan to the public. Black box testing shows that the system can function as it should, and SUS testing obtained an average score of 77.4 and a grade scale B+.
RANCANG BANGUN APLIKASI PENGENALAN WAJAH UNTUK SISTEM PRESENSI DI PRODI TEKNIK INFORMATIKA UNIVERSITAS ISLAM RADEN RAHMAT MALANG MENGGUNAKAN METODE LBPH DAN LIBRARY OPENCV BERBASIS ANDROID
Authors:   Universitas Islam Raden Rahmat Malang, Wulandari Gresy Ayu , Akbar Muhammad Sonhaji , Tasaufi Bila Nastiti
Published: October 2023

The attendance system is a mechanism to record the attendance of students in each class they take. The attendance system serves as evidence of students' presence in the learning process. In its journey, Universitas Islam Raden Rahmat has been using manual attendance through attendance journals in the learning process. However, with technological advancements, the attendance process has followed this trend, one of which is face recognition. In this research, the researcher designed a face recognition application for the attendance system that can be implemented on mobile platforms, especially Android. This application using the Local Binary Pattern Histogram (LBPH) method and the OpenCV library. The objective of this application is to enhance the flexibility and efficiency of the current attendance system by eliminating the need to repeatedly retrieve attendance forms, preventing fraud, and reducing paper usage. By using the waterfall system development method, testing showed a face recognition accuracy of 70%.
APLIKASI DOUBLE DIFFERENCE UNTUK IDENTIFIKASI ZONA PATAHAN MIKRO WILAYAH SULAWESI BARAT
Authors:   Universitas Raharja, Suwardi Suwardi , Djajadi Arko , Subrata Tata , Nudiyah Laura Belani
Published: October 2023

West Sulawesi is an area in South Sulawesi province that is experiencing a sudden increase in seismic activity. There have been 264 earthquake events recorded during the 2021-2022 period. The increase in seismic activity occurred around the west Sulawesi segment and the Mamuju segment, which are local faults located in west Sulawesi. Sulawesi Island itself is the result of fragments due to larger complex reactions and has quite high seismic activity. Therefore, it is necessary to calculate the earthquake hypocenter relocation to obtain more accurate hypocenter parameters for fault zone identification and micro fault orientation. This study aims to relocate the earthquake hypocenter based on mathematical measurement data using the Double-Difference method for identification of fault zones and micro-fault orientation. The data used is BMKG earthquake catalog data for the western Sulawesi region with a range of 118.49 East - 119.59 East and 3.67 LS -2.45 LS in the 2021-2022 period. The Double-Difference method is a method based on the Geiger method using residual travel time data from each pair of hypocenters to the earthquake recording station. The principle is to compare two earthquake hypocenters that are close to the earthquake recording station with the assumption that the distance between the two hypocenters must be closer than the distance between the hypocenter and the earthquake recording station. This is done so that the raypath of the two hypocenters can be considered close to the same value. From the calculation of the earthquake hypocenter relocation, it was found that the hypocenter after relocation experienced changes in distribution that accumulated in the Mamasa fault segment area. From the residual histogram, it is found that the RMS residual is close to 0, indicating an improvement in data quality as evidenced by the observation travel time and the calculated travel time are almost close to the same value. In the cross-section results, it is obtained that the depth changes vary in the subsurface depth from the initial depth of 10 km before being relocated, indicating that the earthquake that occurred in West Sulawesi was included in the shallow crustal earthquake type.
IMPLEMENTASI ALGORITMA FUZZY C-MEANS (FCM) DALAM MEMPREDIKSI HASIL TANGKAPAN IKAN DI KOTA KENDARI
Authors:   Universitas Halu Oleo Kendari, Ngii Katharina Amelia , Sabrina Dinar , Saputra Rizal Adi
Published: October 2023

Almost 70% of Indonesia's region is a body of water, so production of catch fish is increasing. Fish is one of the principal ingredients that most people consume. To meet the rapidly increasing demand of fish requires predictions of fish products that can help with effective planning and decision introduction. The aim of this study is to assess the quality of predictions and provide vital information for future fish production. Fuzzy c-means (FCM) is a technique that can be used to make such predictions using data on water quality, water temperature, and fish production. Analysis using fuzzy c-means means to predict fish production in the next few years. These predictions provide information on the future volume of fish production based on water quality and water temperature data. The results of this study indicate that the method can provide accurate predictions that could be useful for the production of ongoing fish.
PERANCANGAN SISTEM INFORMASI PERPUSTAKAAN DIGITAL BERBASIS WEBSITE MENGGUNAKAN METODE WATERFALL DI JURUSAN INFORMATIKA UNIVERSITAS SILIWANGI
Authors:   Universitas Siliwangi, Lukmana Hen Hen , Alhusaini Muhamad , Purwayoga Vega
Published: October 2023

The COVID-19 pandemic that occurred at the end of 2019 has accelerated the application and use of technology in universities. Various academic activities, such as learning, final project work, and UTS and UAS, were completed online. But unfortunately, supporting facilities such as digital libraries are needed as a source of reference and information that can store various material needs such as ebooks and modules that can be used for the learning process and can be accessed anywhere and anytime. This is the basis for designing the Digital Library Information System to make it easier for lecturers and students to find the books and modules they need. This library information system is web-based and made with HTML, CSS, Javascript, PHP, and MySQL programming languages. The method used in the development of this digital library information system is the waterfall method with the UML (Unified Modeling Language) software approach. With the Informatics Digital Library, it is hoped that it can help students and lecturers find various references and information for the learning process.
SISTEM INFORMASI AKUNTANSI PENERIMAAN DAN PENGELUARAN KAS PADA WISATA NAKNY FUNLAND
Authors:   Universitas Methodist Indonesia, Sitorus Wilona Edra Rachel , Hutapea Marlyna Infryanty , Simanjuntak Arthur
Published: October 2023

One of the tourist attractions from Deli Serdang, North Sumatra, which recently went viral is Nakny Funland. Nakny Funland is frequently visited by local tourists and tourists from outside the region, however currently Nakny Funland still uses the manual method in its system, namely by recording a book system in the process of recording ticket sales and financial reports so there is a high probability that errors can occur in entering data, errors in calculations. data on tickets sold, errors in making financial reports, and can hamper the search process for the data needed. Therefore, we need an accounting information system that can produce faster and more accurate information. The author will create a ticket sales accounting information system at Nakny Funland Tourism using Microsoft Visual Basic 2010 as software and MySQL as database to process the data. The purpose of creating this system is to assist the performance of officers and persons in charge at Nakny Funland Tourism in making the process of recording ticket sales and financial reports easier, faster, and more accurate, and can minimize errors in making records.
SISTEM INFORMASI PERPUSTAKAAN DIGITAL PADA SMP NEGERI 2 SIMPANG EMPAT
Authors:   Universitas Methodist Indonesia, Br. Batubara Anggi Natasya , Perangin-angin Resianta , Purba Eviyanti Novita
Published: October 2023

SMP Negeri 2 Simpang Empat is a junior high school located on JL. Simpang Empat, Ndokum Siroga, Berastagi, Karo Regency. At the current library of SMP Negeri 2 Simpang Empat, it is still done conventionally, namely data handling is still done by way of copying books, which invites data input, which takes a long time and cannot be opened easily and quickly. Therefore, with the existence of a digital library information system that intends to deal with the problems seen in SMP Negeri 2 Simpang Empat, in paying attention to these problems, a system that can process data in the library is needed. The programming languages ​​used are: PHP and MYSQL Database. The existence of a digital library information system at SMP Negeri 2 Simpang Empat can make it easier for students to find books quickly and easily and save time, save energy, save space, save costs in obtaining information.