bluuebunny/crossref_metadata_2025 huggingface dataset:
Evolution of an approach to integration between medical and laboratory information systems.
Authors:   Federal Ailamazyan А. К. Program Systems Institute of Russian Academy of Sciences, Rudetskiy S. V. , Belchenkov A. A. ,   INTERIN Group of companies, Kalinovskiy V. V. ,   INTERIN Group of companies, Morozov M. A. ,   INTERIN Group of companies, Fokht O. A. ,   Federal Ailamazyan А. К. Program Systems Institute of Russian Academy of Sciences
Published: January 2024

Integration between medical and laboratory information systems must take into account all the features of business processes occurring in a medical organization and laboratory. The approach to organizing the interaction of these information systems has changed in accordance with the needs perceived by consumers and the technological capabilities of the software used. The article examines the evolution of methods for integrating LIS and MIS, as well as current problems of interaction between these systems in the Moscow Region and ways to solve them.
Dificuldades na Profissão do Contador Público: um Mapeamento Sistemático no Ambiente Brasileiro
Authors: De Paula Wellington Monte , Bezerra Filho João Eudes
Published: January 2024

Objetivo da pesquisa: O objetivo desta pesquisa foi identificar, agrupar e analisar os principais fatores associados às dificuldades enfrentadas na profissão dos contadores do setor público do Poder Executivo Federal.
Enquadramento Teórico: Revisão da literatura sobre perfil, habilidades e competências dos profissionais da contabilidade e adoção das normas internacionais de contabilidade no setor público (IPSAS).
Método: Foram identificadas vinte e quatro possíveis situações de dificuldades na rotina dos contadores. Metodologicamente, utilizou-se a abordagem quantitativa, exploratória, com corte transversal e aplicação de questionário. A coleta de dados, foi realizada por meio de questionário eletrônico, cuja amostra foi representada por 169 respondentes do poder executivo federal em todos os estados do Brasil.
Resultados: Os resultados apontaram a formação ineficiente dos contadores pesquisados como sendo a principal dificuldade, diante das novas mudanças na contabilidade pública brasileira.
Originalidade: O mapeamento de vinte e quatro fatores associados às dificuldades dos contadores públicos, ante a adoção das IPSAS no Brasil, representa uma contribuição que possibilita promover ações necessárias ao aperfeiçoamento da formação dos contadores do setor público e consequentes mudanças no ambiente organizacional da administração pública brasileira.
Contribuições teóricas e práticas: Consoante a convergência com as normas internacionais de contabilidade do setor público no Brasil (IPSAS), o estudo contribui para o debate acadêmico no processo de formação e profissionalização do contador do setor público do governo federal, isto porque os resultados serão úteis para efetivação e/ou aperfeiçoamento de diretrizes técnicas, metodológicas, gerencias e organizacionais de forma a mitigar as dificuldades ora enfrentadas e identificadas na presente pesquisa.
 
Palavras-chave:Dificuldades dos contadores públicos, Contabilidade pública, Formação dos contadores públicos, Liderança, convergência com IPSAS.
Entangled photon pair generation in an integrated SiC platform
Authors: Ma Lijun , Wang Ruixuan , Li Jingwei , Tang Xiao , Gerrits Thomas , Li Qing , Slattery Oliver , Rahmouni Anouar
Published: January 2024

Entanglement plays a vital role in quantum information processing. Owing to its unique material properties, silicon carbide recently emerged as a promising candidate for the scalable implementation of advanced quantum information processing capabilities. To date, however, only entanglement of nuclear spins has been reported in silicon carbide, while an entangled photon source, whether it is based on bulk or chip-scale technologies, remains elusive. Here, we report the demonstration of an entangled photon source in an integrated silicon carbide platform for the first time. Specifically, strongly correlated photon pairs are efficiently generated at the telecom C-band wavelength through implementing spontaneous four-wave mixing in a compact microring resonator in the 4H-silicon-carbide-on-insulator platform. The maximum coincidence-to-accidental ratio exceeds 600 at a pump power of 0.17 mW, corresponding to a pair generation rate of 9×103 pairs/s. Energy-time entanglement is created and verified for such signal-idler photon pairs, with the two-photon interference fringes exhibiting a visibility larger than 99%. The heralded single-photon properties are also measured, with the heralded g(2)(0)on the order of 10-3, demonstrating the SiC platform as a prospective fully integrated, CMOS-compatible single-photon source for quantum applications.
Artificial Intelligence Chatbots Mimic Human Collective Behaviour
Authors: He James , Wallis Felix , Gvirtz Andrés , Rathje Steve
Published: January 2024

Artificial Intelligence (AI) chatbots, such as ChatGPT, have been shown to mimic individual human behaviour in a wide range of psychological and economic tasks. Do groups of AI chatbots also mimic collective behaviour? If so, artificial societies of AI chatbots may aid social-scientific research by simulating human collectives. To investigate this theoretical possibility, we focus on whether AI chatbots natively mimic one commonly observed collective behaviour: homophily, or people’s tendency to form community with similar others. In a large simulated online society of AI chatbots powered by large-language models (N = 24,443), we find that communities form over time around bots using a common language. In addition, among chatbots that predominantly use English (N = 16,003), communities emerge around bots that post similar content. The findings suggest that AI chatbots mimic homophily, a key aspect of human collective behaviour. Thus, in addition to simulating individual human behaviour, AI-powered artificial societies may advance social science research by allowing researchers to simulate nuanced aspects of collective behaviour.
Pearl Farming Micro-Nanoplastics Affect Oyster Physiology and Pearl Quality
Authors: Gardon Tony , Luyer Jérémy Le , Moullac Gilles Le , Soyez Claude , Lagarde Fabienne , Dehaut Alexandre , Paul-Pont Ika , Huvet Arnaud
Published: January 2024

Pearl farming is crucial for the economy of French Polynesia. However, rearing structures contribute significantly to plastic waste, and the widespread contamination of pearl farming lagoons by microplastics has raised concerns about risks to the pearl industry. This study aimed to evaluate the effects of micro-nanoplastics (MNPs, 0.4–200 µm) on the pearl oyster (Pinctada margaritifera) over a 5-month pearl production cycle by closely mimicking ecological scenarios. MNPs were produced from weathered plastic pearl farming gear and tested at environmentally relevant concentrations (0.025 and 1 µg L–1) to decipher biological and functional responses through integrative approaches. The significant findings highlighted impacts of MNPs on oyster physiology and pearl quality, even at remarkably low concentrations. Exposure to MNPs induced changes in energy metabolism, predominantly driven by reduced assimilation efficiency of microalgae, leading to alteration in gene expression patterns. A distinct gene expression module exhibited a strong correlation with physiological parameters affected by MNP conditions, identifying key genes as potential environmental indicators to nutritional-MNP stress in cultured oysters. The alteration in pearl biomineralization, evidenced by thinner aragonite crystals and the presence of abnormal biomineral concretions, known as keshi pearls, raises concerns about the potential long-term impact on the Polynesian pearl industry.
Mating behavior and oviposition of Palpita forficifera (Lepidoptera: Crambidae)
Authors: Scheunemann Tiago , Manica Roberta , Nornberg Sandro , Gonçalves Rafael , Bernardi Daniel , Nava Dori
Published: January 2024

Palpita forficifera Munroe, 1959 (Lepidoptera: Crambidae) is considered the main pest of the olive tree (Olea europaea L., Oleaceae) in Brazil and Uruguay. The aim of this work was to study the mating and oviposition behavior of P. forficifera in the field and laboratory. In the field, the sex emitting the mating pheromone was determined and in the laboratory, the rate of emergence of males and females; the age, time and duration of mating; number of copulations and oviposition time of P. forficifera were recorded. The field results showed that the males are attracted to the females for mating, and it was possible to capture up to five males per trap in just one night. The emergence rhythm is synchronized. Copulation occurs between the seventh and twenty-third day of life and is most frequent during the third and sixth hours of scotophase. The average duration of the first copulation was 174 minutes, with 35% of couples recopulating, and there were cases of up to five copulations. Oviposition times were concentrated between 20:00 and 02:00. The results obtained provide insight into the reproductive behavior of P. forficifera and are useful for future studies aimed at identifying the sex pheromone to improve monitoring of the pest in olive orchards.
Highly Accurate, Efficient, and Fabrication Tolerance-aware Nanostructure Prediction for High-Performance Optoelectronic Devices
Authors: Seo Min-Ho , Jeong Won-Kyeong , Kim Ki-Hoon , Park Chaehyun , Song Myungkwan
Published: January 2024

Despite extensive efforts to predict optimal nanostructures for enhancing optical devices, a more accurate, efficient, and practical method for nanostructure optimisation is required. In particular, fabrication tolerance is a promising avenue for significantly improving manufacturing efficiency; however, research in this area is limited. In this study, we introduce a practical approach for enhancing the performance of optoelectronic devices using an artificial intelligence (AI)-based nanostructure optimisation strategy. We optimised a support vector regression (SVR) model to capture the complex and nonlinear relationships between the transmittance and nanograting structure variables with the goal of improving optoelectronic devices. Our versatile model accurately predicted the continuous transmittance data with high precision (R2=0.995) using only 216 training data points. It can also make predictions under untrained conditions, thereby enabling the creation of a transmittance nanostructure contour map (R2=0.949). This method facilitates the design of nanostructures tailored to specific optical properties and provides valuable insights into fabrication tolerance. Through experimental validation, we identified an optimal nanograting structure with the highest transmittance in the visible-light spectrum. When integrated into optoelectronic devices such as organic light-emitting diodes (OLEDs) and organic solar cells (OSCs), their performance is significantly improved by increasing the light transmittance. Specifically, devices using the fabricated nanograting film exhibited a 17% improvement in external quantum efficiency (EQE) for solution-processed organic light-emitting diodes (SP-OLEDs) and a 10.7% improvement in power-conversion efficiency (PCE) for OSCs.
Cooperation is encouraged simply by increasing the number of participants
Authors: Tamura Kazuhiro , Morita Satoru
Published: January 2024

Humans have occasionally exhibited cooperative behaviour, deviating from individual rationality, in experiments such as the public goods game and prisoner’s dilemma. Despite numerous experiments, the alignment between human cooperative behaviour and game theory predictions remains inconsistent. Although comprehending human cooperation through experimentation is pivotal, large-scale experiments with human subjects pose challenges, resulting in insufficient data on cooperative behaviour across diverse populations. Here, we present a new approach using Deep Q-Learning-based agents—a type of artificial intelligence—in a public goods game, revealing an intriguing trend, specifically that agents increasingly opt for cooperation as the number of participants rises. This viewpoint challenges prevailing research paradigms by underscoring the importance of group size—an aspect hitherto underexplored. Additionally, this approach mitigates experimental costs, enhancing scalability and eliminating the influence of the details of experimental design. Anticipated outcomes include demonstrating sustained cooperation even in scenarios dominated by non-cooperation in established game theory, thereby narrowing the gap between theoretical predictions and experimental observations. These findings hold potential applications, such as attracting substantial investments for large-scale public projects. Additionally, implementing a mechanism in social networking systems that integrates Deep Q-Learning agents into communities may mitigate fragmentation by promoting cooperative behaviour amongst diverse participants.
Patient satisfaction survey on portable infusion pumps for colorectal cancer chemotherapy: hard-shelled or soft-shelled?
Authors: Yamada Taku , Kikuchi Taketomo , Nagasu Sachiko , Hashimoto Kayoko , Furukawa Eri , Matsumoto Hirokazu , Tsutsumi Kazuki , Tanaka Toshimitsu , Kugishima Miho , Kawaguchi Takumi , Fujita Fumihiko , Higuchi Kyouko , Miwa Keisuke
Published: January 2024

Background
Elastomeric infusion pumps are widely used in colorectal cancer chemotherapy. However, no studies have yet investigated patient preferences regarding different infusion pump types.
Methods
Twenty patients with unresectable colorectal cancer undergoing chemotherapy were initially treated with a portable hard-shelled continuous infusion pump, followed by a soft-shelled continuous infusion pump. The respondents used a numerical rating scale (0–10) to rate their comfort when using each pump, their ease of carrying it, the pump size and shape, its weight, their ease of reading its memory, and their overall satisfaction with it. They were then asked which pump they would ultimately prefer.
Results
In terms of comfort, significantly higher user satisfaction was reported for the soft-shelled pump during the daytime and when going out (P < 0.001, P < 0.001). For pump portability, size, shape, and weight, the soft-shelled type also outperformed the hard-shelled one (P < 0.001, P = 0.0011, P < 0.001). However, the hard-shelled pump scored significantly better in terms of ease of viewing memory (P < 0.001). Overall satisfaction was significantly higher for the soft-shelled pump than the hard-shelled type (p = 0.0095). Finally, 13 patients (65%) indicated that they would prefer a soft-shelled pump for their next treatment, while only one patient (5%) preferred a hard-shelled alternative. A preference for soft-shelled pump was observed, particularly in female patients and those with body mass index of < 22 kg/m2.
Conclusion
Selection portable elastomeric infusion pumps that consider the preferences of patients with colorectal cancer may help improve their quality of life.
Nursery function of red-algal dominated reef in temperate Algoa Bay, South Africa
Authors: James Nicola Caroline , Jacobs Aidan , Gayiza Mihle , Human Lucienne , Steyn Paul-Pierre , Bernard Anthony , Rishworth Gavin
Published: January 2024

Structurally complex macroalgae within coastal seascapes are important as nursery areas for many marine fish species. This study examines the nursery role of a mosaic of red algae dominated habitats in a shallow (< 5 m), sheltered rocky cove in warm-temperate Algoa Bay, South Africa. As an indicator of nursery function within the cove we assessed and mapped macroalgal communities, the resource seascape (epiphytes and invertebrates), as well as fish assemblages (abundance, size structure and species richness) in different subtidal habitat patches. We also looked at the trophic ecology of dominant juvenile fish species within the cove. Red algae, particularly canopy forming Plocamium spp. and lower growing Laurencia spp. dominated subtidal high and low profile reef respectively, with the lower intertidal dominated by coralline turf. Algal complexity (canopy height) was negatively correlated with the biomass of resources, with the biomass of epiphytic algae highest on coralline turf and the abundance of amphipods and polychaetes highest on low growing Laurencia and corralline turf. Laurencia, epiphytes, polychaetes and amphipods were important food sources for juvenile sparids. Although results from this study indicate that lower complexity algae likely provide more food for juvenile sparids, the high abundance of juvenile sparids in Plocamium dominated high profile reef indicates that canopy-forming Plocamium likely provides more shelter from predation than lower complexity algal reef habitats. This shows that macroalgal habitats comprising several functional forms have the potential to support higher juvenile diversity and abundance through both food provision and protection.
Comparison of genetic programming and HEC-HMS as a conceptual model in simulating rainfall-runoff time series
Authors: Sepahvand Reza , Khoshoei mehrdad , Golmohammadi Mohammad Hossein
Published: January 2024

Forecasting the runoff is an essential task in hydrological modeling. Since the factors and parameters affecting the rainfall-runoff process have spatial and temporal variations, they are engaged with significant uncertainty and complexity, leading to some errors in the modeling process, making it a very unwieldy task. This study uses the genetic programming (GP) model to simulate the rainfall-runoff process in Khorramabad River basin located in Iran. To validate the performance of the proposed GP method and accomplish this kind of modeling, this technique is compared to the HEC-HMS conceptual model. For this purpose, the HEC-HMS model is calibrated and employed to simulate the rainfall-runoff process at the first step, modeling four flood events in the study area. In the second step, the GP Model is run as a rainfall-runoff model in the mentioned area. Then, the performance criteria, including the root mean square error (RMSE) of the peak discharge, mean absolute error (MAE), and the observed and simulated flow volume difference, are used to compare two simulation approaches. For example, in the simulation stage of the year 2014, the values of the two mentioned criteria for the genetic programming model were 1.22 and 0.99, while for the hack model, the values were 7.28 and 9.75, respectively. The results suggested that the GP as a data-driven model performs better than the HEC-HMS model as a physics-based one to simulate the rainfall-runoff process in this basin.
The nature of tyrosine-aminated amyloid-β
Authors: Gao Zhonghong , Hu Ting , Wu Jinming , Fu Shitao , Li Hailing
Published: January 2024

Tyrosine residue in amyloid-β (Aβ) is susceptible to attack by various reactive nitrogen intermediates, leading to the formation of 3-nitrotyrosine (3-NT), a post-translational modification associated with the pathophysiology of Alzheimer's disease (AD). Although nitration was considered a "dead-end" product, emerging evidence suggests that 3-NT can be reduced to aminotyrosine in vivo. This study aims to validate the amination of Aβ tyrosine under physiological conditions and systematically investigate its impact on the aggregation and neurotoxicity of Aβ42. Our investigations reveal that tyrosine amination mitigates the highly ordered β-structure content of Aβ42, thereby modulating its aggregation pathway, which is primarily dominated by the multi-step secondary nucleation. Aminotyrosine fibrils exhibit enhanced fragmentation, increasing fibril elongation and insoluble aggregate production. Concurrently, tyrosine amination attenuates the neurotoxicity of Aβ42 by reducing intracellular reactive oxygen species (ROS) production and mitigating cell membrane disruption. Tyrosine amination substantially alters the aggregation and physiological properties of Aβ42. Nitration of Aβ42 and its subsequent conversion to tyrosine-aminated Aβ42 may represent an intrinsic defensive response against AD under nitrative stress.
Association of Body Mass Index with rapid eye movement sleep behavior disorder in Parkinson’s Disease
Authors: Gu Si-Chun , Yuan Xiao-Lei , Yin Ping , Li Yuan-Yuan , Wang Chang-De , Gu Min-Jue , Xu Li-Min , Gao Chen , Wu You , Hu Yu-Qing , Yuan Can-Xing , Cao Yang , Ye Qing
Published: January 2024

Background
The association between body mass index (BMI) and rapid eye-movement (REM) sleep-related behavioral disorder (RBD) in Parkinson’s disease (PD) remains unknown. Our study was to investigate the association of BMI with RBD in PD patients.
Methods
In this cross-sectional study, a total of 1115 PD participants were enrolled from Parkinson's Progression Markers Initiative (PPMI) database. BMI was calculated as weight divided by height squared. RBD was defined as the RBD questionnaire (RBDSQ) score with the cutoff of 5 or more assessed at baseline. Univariable and multivariable logistic regression models were performed to examine the associations between BMI and the prevalence of RBD. Non-linear correlations were explored with use of restricted cubic spline (RCS) analysis. And the inflection point was determined by the two-line piecewise linear models.
Results
We identified 426 (38.2%) RBD at baseline. The proportion of underweight, normal, overweight and obese at baseline was 2.61%, 36.59%, 40.36% and 20.44%, respectively. In the multivariate logistic regression model with full adjustment for confounding variables, obese individuals had an odds ratio of 1.77 (95% confidence interval: 1.21 to 2.59) with RBD compared with those of normal weight. In the RCS models with three knots, BMI showed a non-linear association with RBD. The turning points of BMI estimated from piecewise linear models were of 28.16 kg/m2, 28.10 kg/m2, and 28.23 kg/m2 derived from univariable and multivariable adjusted logistic regression models. The effect modification by depression on the association between BMI and RBD in PD was also found in this study. Furthermore, the sensitivity analyses linked with cognition, education, and ethnic groups indicated the robustness of our results.
Conclusion
The current study found a significant dose-response association between BMI and RBD with a depression-based difference in the impact of BMI on RBD in PD patients.
POT1 tumor predisposition: a broader spectrum of associated malignancies and proposal for additional screening program
Authors: Freitas Marta Baptista , Desmyter Laurence , Badoer Cindy , Smits Guillaume , Vandernoot Isabelle , de Roodenbeke Daphné t´Kint
Published: January 2024

Protection of Telomeres Protein 1 protein is an essential subunit of the shelterin telomere binding complex, regulating telomere length. Some POT1 gene pathogenic variants lead to telomere elongation and consequently genomic instability, which predisposes to a higher risk of cancer. POT1 tumour predisposition (POT1-TPD) is inherited in an autosomal dominant manner and it is related to an increased lifetime risk for cutaneous melanoma, chronic lymphocytic leukaemia (CLL), angiosarcoma (mostly cardiac angiosarcomas) and gliomas. In this work, we aim to describe a broader cancer phenotype related to POT1 tumour predisposition, in three different families. We performed genetic tests in 3 index cases identifying 3 different POT1 pathogenic variants: NC_000007.14(NM_015450.2):c.349C > T; NC_000007.14(NM_015450.2):c.233T > C and NC_000007.14(NM_015450.2):c.818G > A; already described in the literature. In total, thirty-four family relatives were tested and eighteen were positive. In these three families, it was possible to observe the typical POT1-TPD (cutaneous melanoma, cardiac angiosarcoma, chronic lymphocytic leukaemia and brain tumours). Nonetheless, these families present a higher incidence of other types of cancers: bone and soft tissue sarcomas, lung cancer, papillary thyroid cancer, early onset prostate cancer and leukaemia in association with POT1 pathogenic variants. These findings are important to better understand the implications of POT1 pathogenic variants, their prevalence, their penetrance and better characterize them. Furthermore, it can play an important role in future discussions about POT1 mutation screening criteria, improving genetic counselling of these patients and their families and also help to developed more accurate surveillance protocols for POT1 carriers.
Development and Psychometric Properties of a Lifestyle-Related Behaviors & Barriers Scale (LBBS) among Young Adults
Authors: Ranjan Piyush , Anwar Wareesha , Malhotra Anita , Upadhyay Ashish , Kapoor Gautam , Verma Mehak , Singh Amandeep , Prakash Bindu , Deb Koushik , VIKRAM NAVAL
Published: January 2024

Background & Aim: The management of obesity has unique characteristics and challenges in different age groups. Effective redressal requires the recognition of unhealthy lifestyles through reliable and valid assessments targeting young adults (YAs). The present study is dedicated to formulating and evaluating the psychometric attributes of an all-encompassing questionnaire to assess lifestyle-related behavior and associated barriers.
Methods: The tool was formulated through a mixed-method study design, including item generation, assessment of content validity by experts, face validity through pre-testing, and construct validity through exploratory factor analysis (EFA). The dimensionality and discriminant validity were tested through structural equation modeling (SEM) by confirmatory factor analysis (CFA). Reliability, stability, and internal consistency were also confirmed by conducting a test-retest assessment using Cronbach’s alpha and Intraclass correlation (ICC).
Result: A tool with four latent factors and 17 items was found a good fit after EFA and subsequent CFA. A total of 302 participants were recruited for EFA, and 152 participants were subjected to SEM through CFA. Additional data from 102 participants was taken after one week for test-retest reliability. The tool demonstrated good reliability, stability, internal consistency (Cronbach’s alpha: .72, ICC= 0.960, CI= 0.952 to 0.971).
Conclusion: This study has successfully developed a concise and reliable questionnaire for assessing obesity-related factors in YAs, addressing the limitations of prior tools. The questionnaire holds promise for widespread use in clinical, research, and public health settings, facilitating assessments and interventions.
Quality and quantity of topsoil organic matter in monospecific and mixed pine forests: role of overstory and understory vegetation
Authors: López-Marcos Daphne , Turrión María-Belén , García-Duro Juan , Bravo Felipe , Martínez-Ruiz Carolina
Published: January 2024

Hypothesis and aims
The topsoil organic matter dynamics in mixed vs. monospecific pine stands responds to the vegetation composition. Thus, we tested the effect of the stand type and every under- and overstory species as well as the understory richness in forest floor and topsoil organic matter variability in a fine-scale approach.
Methods
The study of topsoil (5cm depth), forest floor (25 cm x 25 cm), understory (1 m x 1 m), and overstory (4 m radio) in 180 plots [6 triplets x 3 forest stands (PS: P. sylvestris monospecific stand; PP: P. pinaster monospecific stand; MM: mixed stand of both Pinus species) x 10 plots/stand] was implemented in a triplets’ essay in North-Central Spain.
Results
The topsoil organic matter quantity (~ TOC) described an expected trend given the overstory composition (PS > MM > PP) but quality (~ - C/N) showed an unexpected trend (PS ~ MM > PP) that we found related to the understory richness.
Conclusion
The quantity and quality of topsoil organic matter in mixed pine stands respond to the overstory, but also to the understory. Management strategies oriented to understory conservation to maintain dynamics of organic matter that promote carbon sequestration are recommended.
An updated method on the injectivity of integral operators related to Riemann Hypothesis
Authors: Adam Dumitru
Published: January 2024

A new theorem on the injectivity of the linear operators on separable Hilbert spaces is introduced, extending the Injectivity Criteria from [1]. The theorem stated: A linear bounded operator strict positive on a dense set of a separable Hilbert space, is injective.
Some observations regarding the analogy of the orthogonal projections defined by finite rank integral operators with the methods of the domain restriction to subspaces and Galerkin discretization are made: the matrix representations on the same subspaces differ only by normalisation factor introduced by the finite rank operator orthogonal projections. So, the new theorem will apply to the orthogonal projections by finite rank operators instead, for Galerkin and restriction method the Injectivity Criteria should be applied. Any of the methods used, provided the injectivity of the integral operator from the Alcantara-Bode equivalent formulation of the Riemann Hypothesis. As result, we claim that Riemann Hypothesis holds.
subjclass: 65R99, 47G10, 45P05
The effect of fluoroquinolones on the cancer development in patients with interstitial lung disease and virus infection
Authors: Yeh Jun-Jun , Sun Yi-Fan , Tang Hsien-Chin , Li Chia-Hsun , Kao Hsuan-Min , Lin Cheng-Li , Kao Chia-Hung
Published: January 2024

The virus increased risk of cancer and fluoroquinolones (FQs) could induce the interstitial lung disease (ILD) such as acute interstitial pneumonitis. The effects of FQs on the risk of cancer in patients having theILD concurrent with virus infection (ILD cohort) based on the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9CM) is to be determined. The propensity score was calculated based on age, sex, index date, and medications of these comorbidities. Through the January 2000 to December 2013, the ILD cohort with FQs use (FQs cohort, N = 3,264) and those in the ILD cohort without FQs use (non-FQs cohort, N = 3,264) enter into study. Cox proportional regression with time-dependent exposure covariates was used to analyze the cumulative incidence of cancer. Adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for cancer were determined after controlling for sex, age, medications (anti-inflammatory drugs, immunosuppressants), and comorbidities, as well as the use of FQs. Compared with the non-FQs cohort, the FQs cohort had aHRs (95% CIs) for cancer, colorectal cancer, lung cancer, and prostate cancer were 0.70 (0.59–0.83), 0.56 (0.37–0.85), 0.56 (0.38–0.85), and 2.39 (1.27–4.49) respectively. For patients with a single use of FQ>4≤ 15 days/ >15 days, the aHRs (95% CIs) were 0.50 (0.32–0.78)/1.83(0.71–4.70), 0.47 (0.31–0.73)/ 2.08 (0.97-4.48), and 1.94 (1.01–3.74)/ 12.1 (4.73–31.1) for colorectal, lung, and prostate cancers, respectively. The trend of the increase of the value of the aHR was found in these three cancers. For the patients with the cumulative daily dose FQ>4000mg ≤ 15 000mg/ >15 000mg, the similar trend was found also.Meanwhile, the use of FQs >4 ≤15 days (4000mg ≤15000mg) was associated with a lower aHR for colorectal cancer and lung cancer in selected cases (drug sensitive). The use of the FQs >15 days(>cDDD15000 mg) was with a higher aHR for cancers such as prostate cancer (drug resistance). Perhaps, the FQs with drug sensitive for colorectal cancer and lung cancer may play an auxiliary role for prevention of these two cancers. Meanwhile, the FQs with drug resistance may not play a role for prevention of the prostate cancer. However, confounding factors such as drug resistance and a higher rate of medical services must be considered in the prostate cancer cohort.
Early diagnosis and surgical management of heterotopic pregnancy following in vitro fertilization-embryo transfer: A retrospective cohort study
Authors: He Jiajing , Shen Haofei , Wang Wei , Wang Lirong , Ma Xiaoling , Zhang Xuehong
Published: January 2024

Objective: The purpose of this study was to evaluate the efficacy of laparoscopic surgery for heterotopic pregnancy (HP), and to compare the clinical characteristics between HP, twin pregnancy and single pregnancy. The ROC curve was constructed to provide help for the early diagnosis of HP.
Design: This was a retrospective cohort study.
Setting: Reproductive Medicine Hospital of the First Hospital of Lanzhou.
Patients: Cases of HP (n=30), twin pregnancy (n=467) and single pregnancy (n=1127) were retrieved from the registry database.
Intervention: All patients diagnosed with HP underwent laparoscopic surgery.
Measurements: Clinical characteristics including age, body mass index (BMI), infertility type, menarche age, gravidity, parity, history of EP, number of retrieved oocytes, number of transferred embryos, surgery (initial symptom, EP site, surgical management), and pregnancy outcome (neonatal weight, live birth, miscarriage rate, preterm delivery rate) were recorded. Serum β-hCG, serum estradiol(E2) and serum progestin(P) were tested at 14 days after ET.
Main results: The live birth rate of HP was 66.6% and the miscarriage rate was 33.3%. Fourteen days after embryo transfer, the serum levels of β-human chorionic gonadotropin(β-hCG), estradiol(E2) and progestin(P) were lower in the HP group than in the twin pregnancy group(P<0.05). But there were no differences in the level of serum β-hCG, E2 between HP group and single group(P>0.05). The area under receiver operating characteristic (ROC) curve (AUC) of serum β-hCG-ET14d between HP and twin pregnancy were 0.80, 95% confidence interval (0.73-0.87), the cut-off value of β-hCG-ET14d was 1117 mIU/ml. The area under receiver operating characteristic (ROC) curve (AUC) of serum β-hCG-ET14d between HP and single pregnancy were 0.53, 95% confidence interval (0.44-0.62), the cut-off value of β-hCG-ET14d was 404.4 mIU/ml. The history of ectopic pregnancy in HP group was higher than that that in twin pregnancy group and single group (P <0.05). There were no differences in the intraoperative blood loss between live birth group and abortion group. The birth weight in HP group was similar with the single group(P>0.05), both all lower than the twin group(P<0.05).
Conclusion: This retrospective study suggested that a history of ectopic pregnancy may increase the risk of HP. β-hCG could not be an predictor for HP in the early stages. Intraoperative blood loss in laparoscopic surgery had no influence on the pregnancy outcomes.
CPI-613 Suppresses Pancreatic Cancer Stem-Like Cells by Targeting the SEMA3A/NRP1 Pathway
Authors: Li Zhuanghua , Xie Baocheng , Wu Peishan , Wang June , Liu Hongyu , Dong Zhuo , Huang Linxuan
Published: January 2024

Pancreatic cancer is known for its recurrence and chemotherapy resistance, partly attributed to cancer stem cells (CSCs). Targeting CSCs could improve the efficacy of standard cytotoxic therapies and potentially prevent or delay cancer recurrence. The increased reliance on the modulation of metabolic pathways in CSCs offers a potential therapeutic opportunity. In this study, we investigated the effects of CPI-613 (Dedvimistat), a metabolic inhibitor that targets the tricarboxylic acid cycle on pancreatic cancer cells. We demonstrate that treatment with CPI-613 significantly reduced the capacity to form CSCs, furthermore, CPI-613 showed decreased tumorigenicity in vivo. To gain further insights into the molecular mechanisms underlying the effects of CPI-613, RNA-Seq analysis was performed. CPI-613 impeded the unintended enrichment of CSC through target SEMA3A (Semaphorin 3A) and its receptor NRP1 (Neuropilin 1). Knockdown of SEMA3A significantly inhibited the proliferation of CD44 + frequency and increased their sensitivity to gemcitabine. Moreover, treatment with exogenous SEMA3A counteracted the inhibitory effect of CPI-613 on CSC proliferation and promoted resistance to gemcitabine. Our findings suggest that CPI-613 selectively targets pancreatic CSCs through the SEMA3A/NRP1 pathway. CPI-613 has the potential to overcome chemoresistance and prevent cancer recurrence by targeting CSCs.
Specific EEG resting state biomarkers in FXS and ASD
Authors: Proteau-Lemieux Mélodie , Knoth Inga Sophia , Davoudi Saeideh , Martin Charles-Olivier , Bélanger Anne-Marie , Fontaine Valérie , Côté Valérie , Agbogba Kristian , Vachon Keely , Whitlock Kerri , Biag Hazel Maridith Barlahan , Thurman Angela John , Rosenfelt Cory , Tassone Flora , Frei Julia , Capano Lucia , Abbeduto Leonard , Jacquemont Sébastien , Hessl David , Hagerman Randi Jenssen , Schneider Andrea , Bolduc Francois , Anagnostou Evdokia , Lippe Sarah
Published: January 2024

Background: Fragile X syndrome (FXS) and autism spectrum disorder (ASD) are neurodevelopmental conditions that often have a substantial impact on daily functioning and quality of life. FXS is the most common cause of inherited intellectual disability (ID) and the most common monogenetic cause of ASD. Previous literature has shown that electrophysiological activity measured by electroencephalogram (EEG) during resting state is perturbated in FXS and ASD. However, whether electrophysiological profiles of participants with FXS and ASD are similar remains unclear. The aim of this study was to compare EEG alterations found in these two clinical populations presenting varying degrees of cognitive and behavioral impairments.
Methods: Resting state EEG signal complexity, alpha peak frequency (APF) and power spectral density (PSD) were compared between 47 participants with FXS (aged between 5-20), 49 participants with ASD (aged between 6-17), and 52 neurotypical (NT) controls with a similar age distribution using one-way ANOVAs. ANCOVAs controlling for nonverbal intellectual quotient (NVIQ) scores were subsequently performed to determine the impact of cognitive functioning on EEG alterations.
Results: Our results showed that FXS participants manifested decreased signal complexity and APF compared to ASD participants and NT controls, as well as altered power in the alpha, beta, and low gamma frequency bands. ASD participants showed exaggerated beta power compared to FXS participants and NT controls, as well as enhanced low and high gamma power compared to NT controls. However, ASD participants did not manifest altered signal complexity or APF. Furthermore, when controlling for NVIQ, results of decreased complexity in higher scales and lower APF in FXS participants compared to NT controls and ASD participants were not replicated.
Conclusions: These findings suggest that signal complexity and APF might reflect cognitive functioning, while altered power in the low gamma frequency band might be associated with neurodevelopmental conditions, particularly FXS and ASD.
Environmental Considerations of Alternative Livelihoods for Women in Cocoa and Shea Communities in Ghana
Authors: Duorinaah Eric , Achanso Adams , Muntaka Hafix
Published: January 2024

Women in cocoa and shea communities have traditionally relied on the extraction of environmental resources for their livelihoods. Due to climatic, economic and social variabilities however, the traditional sources are no longer able to sustain their households and as a result, women are gradually up taking some alternative livelihood sources particularly during offseason. This study explored the effect of such alternative livelihood sources in the cocoa and shea communities on the physical environment. A case study design was employed for the study. In-depth interviews and focus group discussions were the main means for obtaining the requisite data from 131 respondents; 88.7% of whom were women drawn from ten communities in three regions in five geographic districts in Ghana. The study revealed that about eighteen alternative livelihood sources pursued by women were key in providing the needs of most households and their effect on the physical environment was negligible. The exceptions were vegetable cultivation, guinea fowl rearing and dawadawa processing in some communities which recorded appreciable negative effect largely due to poor management practices. The study recommended that, to improve and sustain the quality of the environment, there was the need for proper waste disposal practices and the enforcement of policies and laws that prohibit the use of pesticides and other harmful chemicals used in the alternative livelihood activities.
Positive Psychology in Language Teaching: Investigating Factors Influencing Women Language Teacher Well-being under the "UP or Out" Policy
Authors: Qu Kunyang , Wu Xuande
Published: January 2024

The psychological well-being of educators is imperative, especially when navigating complex career dynamics such as China's "up or out" policy. This research investigates the well-being of women L2 teachers across various Chinese educational institutions. Utilising a multiple linear regression model, the study unpacks relationships between system-related teacher anger, work engagement, teaching enjoyment, job satisfaction, emotion regulation behaviour, and overall psychological health. The result shows a strong positive link between work engagement and emotion regulation behaviour. Moreover, job satisfaction is pivotal to emotion regulation and psychological well-being. By highlighting the profound influence of emotion regulation, this study provides essential insights into China's unique educational context. The results offer valuable directives for policymaking, educator training, and institutional practices, all aiming to fortify the psychological well-being of L2 teaching professionals.
Relaxing environments make people with high neuroticism more concentrated: An EEG study of auditory steady-state response
Authors: Hashizume Ayana , Yamamoto Masataka , Nakadai Hisanao , Takemura Hiroshi
Published: January 2024

Considering that new ways of working are increasing in modern society, where people can choose their own workspace, workers must understand the most suitable environment for concentration. Personality is crucial for determining a suitable and focused environment for each individual. However, few studies have investigated the relationship between personality and the environment, in which it is easy to concentrate using objective methods. We explored whether differences exist in the environment in which people can concentrate easily, depending on their personalities. We measured concentration using the auditory steady-state response, a brain response to sound. For each of the Big Five personality factors, we compared concentration after presenting videos simulating both relaxed and tense environments and investigated the relationship with personality scores. The results indicated a negative correlation between neuroticism scores and concentration in a tense environment. People with lower neuroticism concentrated more in a tense environment, while those with higher neuroticism concentrated more in a relaxed environment. These findings not only assist employees in choosing their workspace but also may support educational settings such as schools and universities.
Endothelial tip-cell position, filopodia formation and biomechanics require BMPR2 expression and signaling
Authors: Knaus Petra , Hiepen Christian , Benamar Mounir , Barrasa-Fano Jorge , Cóndo Mar , Ilhan Mustafa , Münch Juliane , Hastar Nurcan , Kerkhoff Yannic , Harms Gregory , Mielke Thorsten , König Benjamin , Block Stephan , Seyfried Salim , Oosterwyck Hans Van
Published: January 2024

Blood vessel formation relies on biochemical and mechanical signals, particularly in sprouting angiogenesis where endothelial tip cells (TCs) guide sprouting through filopodia formation. The role of BMP receptors in defining endothelial tip-cell characteristics remains unclear. Our study elucidates the pivotal role of BMPR2 in actin-driven filopodia formation and mechanical properties of endothelial cells (ECs). Targeting bmpr2b in zebrafish impairs sprouting angiogenesis, while BMPR2-deficient human ECs diminished filopodia, impacting cell migration and actomyosin localization. Spheroid assays reveal reduced sprouting in fibrin gels, and in mosaic spheroids, BMPR2-deficient ECs fail to acquire tip-cell positions. Surprisingly, 3D traction force microscopy shows no significant differences in force-induced matrix deformations from BMPR2-deficient tip cells, which instead adopt a distinct cone-shaped morphology. BMPR2 localizes near filopodia interacting with BORG5 to regulate CDC42. Our findings unveil BMPR2 as a central hub integrating biochemical and biomechanical processes crucial for endothelial tip cells during angiogenesis.
Causal relationship between COVID-19 and membranous nephropathy: A bidirectional Mendelian randomization study
Authors: Zhou Tong , Zhang Heping , Zhao Jiayu , Ma Yimei , He Linqian , Ren Zhouting , Lin Fulian , Chen Zhihui , Yang Kun , Tang Jincheng , Liu Jiali , Deng Fei
Published: January 2024

Recent studies have suggested a potential link between COVID-19 and the initiation or exacerbation of membranous nephropathy (MN) caused by the SARS-CoV-2 virus. However, a causal relationship between COVID-19 and MN remains unconfirmed. Here, we used the Mendelian randomization (MR) approach to investigate whether this causal relationship exists. We utilized data from the COVID-19 Host Genetics Initiative, comprising the largest available genome-wide association study (GWAS) datasets from European and East Asian populations. For MN, we used the largest literature-reported GWAS dataset. We selected single nucleotide polymorphisms as instrumental variables and used the inverse variance weighted (IVW) method, supplemented with MR Egger, weighted median, and mode methods. The MR-Egger intercept test and the MR-PRESSO global test were applied to assess horizontal pleiotropy. The robustness of the MR findings was evaluated using Cochran’s Q test and leave-one-out analysis. In both cohorts, MR methods showed SARS-CoV-2 infection, hospitalization, and severe COVID-19 did not increase the risk of MN. Conversely, MN potentially increased the risk of COVID-19-related hospitalization in Europeans, supported by the IVW and other methods. In East Asians, MR Egger suggested an increased risk of severe COVID-19 associated with MN, but other MR methods did not support this. No significant evidence of horizontal pleiotropy was detected. Cochran’s Q test showed no heterogeneity, and leave-one-out analysis confirmed the MR findings' reliability. The bidirectional MR analysis confirmed that COVID-19 did not increase MN risk, but MN might increase the risk of COVID-19-related hospitalization in Europeans, indicating a potential causal relationship.
Mechanism of SETX-BRCA1-BARD1 complex in resolution of R-loops and transcription-replication conflicts
Authors: Sung Patrick , Dutta Arijit , Ji Jae-Hoon , Fang Qingming , Zhou Shuo , Liang Fengshan , Nyalwidhe Julius , Dray Eloise , Verway-Cohen Amy , McDonald Drew , Avalos Bárbara de la Peña , Li Wenjing , Herrero Ane , Fitzgerald O’Taveon , Taylor Alexander , Kwon Youngho , Semmes Oliver , Tsai Miaw-Sheue , Hromas Robert , Burma Sandeep , Bishop Alexander , Mazin Alexander , Wasmuth Elizabeth , Olsen Shaun , Zhou Daohong , Zhao Weixing , Kupfer Gary
Published: January 2024

Senataxin (SETX), a putative RNA-DNA helicase, is recruited to transcription pause sites via the tumor suppressor BRCA1. Here, we define the mechanism by which SETX-BRCA1 resolves transcription-associated R-loops to prevent deleterious outcomes. Specifically, we show that SETX unwinds R-loops, and that the complex of BRCA1 and its obligatory partner BARD1 binds R-loops and stimulates R-loop unwinding by SETX. Importantly, BRCA1-BARD1 alleviates the inhibitory effect of RAD52 on SETX-mediated R-loop unwinding. We also demonstrate that phosphorylation of Ser642 in SETX promotes its interaction with BRCA1 via the tandem BRCT domain of the latter. Accordingly, mutations in the catalytic domain or Ser642 in SETX lead to R-loop accumulation, transcription-replication conflicts, replication fork stalling, and DNA double strand breaks in human cells. Our results thus establish the molecular basis for functional synergy between SETX and BRCA1-BARD1 in R-loop resolution and the mitigation of transcription-replication conflicts to preserve genome integrity.