bluuebunny/crossref_metadata_2025 huggingface dataset:
The Role of Hunters in Wildlife Health Research and Monitoring: Their Contribution as Citizen Scientists in Italy
Authors: Zanet Stefania , Benatti Francesco , Poncina Manuela , Pasetto Carlotta , Chiari Mario , Sorrenti Michele , Ferroglio Ezio
Published: July 2024

In Italy, there are hundreds of research, monitoring, and surveillance activities targeting emerging and re-emerging pathogens. These activities heavily rely on hunters for sample collection and early identification of morbidity/mortality events. The objective of this review is to describe and quantify the contribution of hunters in the context of disease research, monitoring, and surveillance in wild populations. A literature review and descriptive summary statistics were performed following PRISMA-2020 guidelines; articles were obtained from major scientific databases, abstracts from national and international conferences, proceedings, graduate-level theses from online library repositories, and direct contact with academic experts. The contribution of hunters in terms of sample collection for health-related activities on wildlife amounts to 400,000 sampled animals. Wild boars were involved in 158 surveillance systems/research studies, followed by red deer (71), foxes (63), and roe deer (59). The pathogens under surveillance were mainly zoonotic (Salmonella spp.), emerging (Hepatitis E virus), and/or vector-borne (West Nile virus). The temporal distribution of scientific papers followed a positive trend that reflects the growing interest in wildlife from different sectors. These results highlight how wildlife health-related efforts are a paradigm of the concept of One Health, in which the role of hunters is crucial to ensure sample availability, and it constitutes the base of much current wildlife health research, monitoring, and surveillance.
Numerically Investigating the Effect of Trim on the Resistance of a Container Ship in Confined and Shallow Water
Authors: Martić Ivana , Anušić Barbara , Degiuli Nastia , Grlj Carlo Giorgio
Published: July 2024

One of the promising strategies for the improvement of the resistance characteristics and energy efficiency of a ship is trim optimization. Most of the studies conducted so far regarding trim optimization deal with unrestricted water. The effect of trim on the total resistance and its components for the KRISO Container Ship model in confined and shallow water is investigated using computational fluid dynamics. Numerical simulations of resistance tests with and without the free surface effects using two turbulence models are carried out for even keel and four trims in restricted water. A verification study is conducted for the total resistance, sinkage, and trim in terms of grid resolutions and time steps to assess the numerical uncertainty. The numerical results are validated against the experimental ones available in the literature. Performing the double body simulations enabled the analysis of the effect of trim on the resistance components. The numerical results pointed out that by adjusting the trim a reduction in the total resistance in confined and shallow water can be obtained.
Estimation of Photovoltaic Potential of Solar-Powered Electric Vehicle: Case Study of Commuters on Donghae Expressway, Korea
Authors: Suh Jangwon
Published: July 2024

Studies on solar electric vehicles (EVs) have focused on calculating the power generation in a specific environment without discussing its practical utility. To expand the awareness of the utility of solar EVs, their potential should be evaluated by considering the operation methods of users. This study investigated the photovoltaic (PV) potential of an EV integrated with PV modules while driving on an expressway. Tunnel and shadow areas were identified to determine unpowered areas on the expressway. The PVWatts model was used to evaluate the PV potential by the time of the year. For a single vehicle traveling at 60 km/h on the Donghae expressway section during both the summer and winter solstices, the amount of power generation is within 0.208–0.317 kWh, corresponding to 0.94–1.43% of the electricity consumed for driving. Furthermore, this study assumed that office workers commute on the Donghae expressway. Under the scenario considering the time of operation (traveling to and from work and parking at work) and the shading ratio, the rechargeable amount was more than 10% of the electricity consumption. The results showed that solar roofs are potential charging supplements for EV batteries. This study can provide the efficacy and optimal operation method of solar EVs for commuters.
Imperial Art: Duality on Tanwetamani’s Dream Stela
Authors: Cox Christopher
Published: July 2024

In the 7th century BCE, the Kushite king Tanwetamani commissioned his “Dream Stela”, which was to be erected in the Amun Temple of Jebel Barkal. The lunette of the stela features a dualistic artistic motif whose composition, meaning, and significance are understudied despite their potential to illuminate important aspects of royal Kushite ideology. On the lunette, there are two back-to-back offering scenes that appear at first glance to be nearly symmetrical, but that closer inspection reveals to differ in subtle but significant ways. Analysis of the iconographic and textual features of the motif reveals its rhetorical function in this royal context. The two strikingly similar but meaningfully different offering scenes represented the two halves of a Kushite “Double Kingdom” that considered Kush and Egypt together as a complementary geographic dual, with Tanwetamani presiding as king of both. This “Mirrored Motif” encapsulated the duality present in the Kushite ideology of kingship during the Twenty-Fifth Dynasty, which allowed Tanwetamani to reconcile the present imperial expansion of Kush with the history of Egyptian activity in Nubia. The lunette of the Dream Stela is therefore political art that serves to advance the Kushite imperial agenda.
Positive Fitted Finite Volume Method for Semilinear Parabolic Systems on Unbounded Domain
Authors: Koleva Miglena N. , Vulkov Lubin G.
Published: July 2024

This work deals with a semilinear system of parabolic partial differential equations (PDEs) on an unbounded domain, related to environmental pollution modeling. Although we study a one-dimensional sub-model of a vertical advection–diffusion, the results can be extended in each direction for any number of spatial dimensions and different boundary conditions. The transformation of the independent variable is applied to convert the nonlinear problem into a finite interval, which can be selected in advance. We investigate the positivity of the solution of the new, degenerated parabolic system with a non-standard nonlinear right-hand side. Then, we design a fitted finite volume difference discretization in space and prove the non-negativity of the solution. The full discretization is obtained by implicit–explicit time stepping, taking into account the sign of the coefficients in the nonlinear term so as to preserve the non-negativity of the numerical solution and to avoid the iteration process. The method is realized on adaptive graded spatial meshes to attain second-order of accuracy in space. Some results from computations are presented.
Weighted Composition Operators between Bers-Type Spaces on Generalized Hua–Cartan–Hartogs Domains
Authors: Wang Ziyan , Su Jianbing
Published: July 2024

We address weighted composition operators between Bers-type spaces on generalized Hua–Cartan–Hartogs domains and provide the necessary and sufficient conditions for their boundedness and compactness. We then apply our results to study the boundedness and the compactness of weighted composition operators between Bers-type spaces on four different domains: generalized Hua domains, generalized Cartan–Hartogs domains, generalized Cartan–Hartogs domains over different Cartan domains and generalized ellipsoidal-type domains, by proving that the above four different domains are special cases of the generalized Hua–Cartan–Hartogs domains.
A New Methodology for the Development of Efficient Multistep Methods for First-Order Initial Value Problems with Oscillating Solutions: III the Role of the Derivative of the Phase Lag and the Derivative of the Amplification Factor
Authors: Simos Theodore E.
Published: July 2024

Recently, the author developed a theory for the computation of the phase lag and amplification factor for explicit and implicit multistep methods for first-order differential equations. In this paper, we will investigate the role of the derivatives of the phase lag and the derivatives of the amplification factor on the efficiency of the newly developed methods. We will also present the stability regions of the newly developed methods. We will also present numerical experiments and conclusions on the newly developed methodologies.
Experimental and Modeling Study of Arc Fault Induced Thermal Runaway in Prismatic Lithium-Ion Batteries
Authors: Xu Wenqiang , Zhou Kai , Wang Hewu , Lu Languang , Gao Bin , Wang Yan , Li Yalun
Published: July 2024

With the widespread application of electrochemical energy storage technology, the safety issues of lithium-ion batteries have garnered significant attention. The issue of arc faults resulting from electrical failures is especially critical, as it can lead to catastrophic battery disasters. Therefore, this paper first established an arc testing platform and conducted experiments on top cover and body of prismatic lithium-ion batteries to analyze the thermoelectric characteristics between arc and battery. Under experimental conditions of 300 V and 15 A, it was found that arcs can induce thermal runaway in batteries. Subsequently, based on the experimental conditions, a mathematical model was established to induce thermal runaway in batteries through an equivalent method of arc heat source. By comparing the temperature curves of model and experiment, the RMSE of temperature at the center point of large surface was 5.09 °C (with a maximum temperature of 212 °C), indicating the accuracy of the model. This paper’s research on arc faults in battery systems revealed the evolution pattern and realized that arcs can trigger thermal runaway in batteries. The model for arc-triggered thermal runaway in batteries is highly accurate, capable of reducing the number of experiments, accelerating experimental progress, and is of significant importance for guiding the design of arc experiments about batteries.
Experimental Research on Thermal-Venting Characteristics of the Failure 280 Ah LiFePO4 Battery: Atmospheric Pressure Impacts and Safety Assessment
Authors: Wang Yu , Wang Yan , Zhao Jingyuan , Li Hongxu , Xu Chengshan , Li Yalun , Wang Hewu , Lu Languang , Dai Feng , Yu Ruiguang , Qian Feng
Published: July 2024

With the widespread application of lithium-ion batteries (LIBs) energy storage stations in high-altitude areas, the impact of ambient pressure on battery thermal runaway (TR) behavior and venting flow characteristics have aroused wide research attention. This paper conducts a lateral heating experiment on 280 Ah lithium iron phosphate batteries (LFPs) and proposes a method for testing battery internal pressure using an embedded pressure sensor. This paper analyzes the battery characteristic temperature, internal pressure, chamber pressure, and gas components under different chamber pressures. The experiment is carried out in a N2 atmosphere using a 1000 L insulated chamber. At 40 kPa, the battery experiences two instances of venting, with a corresponding peak in temperature on the battery’s side of 136.3 °C and 302.8 °C, and gas generation rates of 0.14 mol/s and 0.09 mol/s, respectively. The research results indicate that changes in chamber pressure significantly affect the center temperature of the battery side (Ts), the center temperature of the chamber (Tc), the opening time of the safety valve (topen), the triggering time of TR (tTR), the time difference (Δt), venting velocity, gas composition, and flammable limits. However, the internal pressure and gas content of the battery are apparently unaffected. Considering the TR characteristics mentioned above, a safety assessment method is proposed to evaluate the TR behavior and gas hazard of the battery. The results indicate that the risk at 40 kPa is much higher than the other three chamber pressures. This study provides theoretical references for the safe use and early warning of energy storage LIBs in high-altitude areas.
An Annotated Checklist of Invasive Species of the Phyla Arthropods and Chordates in Panama
Authors: Rodríguez-Gavilanes Digna , Garcés Botacio Humberto A. , Fuentes Rogemif , Rodriguez-Scott Louise , Añino Yostin , López-Chong Oscar G. , Medianero Enrique
Published: July 2024

Invasive species are one of the five main causes of biodiversity loss, along with habitat destruction, overexploitation, pollution, and climate change. Numbers and species of invasive organisms represent one of the first barriers to overcome in ecological conservation programs since they are difficult to control and eradicate. Due to the lack of records of invasive exotic species in Panama, this study was necessary for identifying and registering the documented groups of invasive species of the Chordates and Arthropod groups in Panama. This exhaustive search for invasive species was carried out in different bibliographic databases, electronic portals, and scientific journals which addressed the topic at a global level. The results show that approximately 141 invasive exotic species of the Arthropoda and Chordata phyla have been reported in Panama. Of the 141 species, 50 species belonged to the Arthropoda phylum and 91 species belonged to the Chordate phylum. Panamanian economic activity could facilitate the introduction of alien species into the country. This study provides the first list of invasive exotic chordate and arthropod species reported for the Republic of Panama.
Evaluation of Two Ecosystem Services Provided by a Pistia stratiotes Population on the Pacific Coast of South America
Authors: Zamora-Aranda Adela , Aponte Héctor
Published: July 2024

One of the most fascinating wetlands on Peru’s central coast is the Santa Rosa wetland (Chancay, Lima), an ecosystem threatened by anthropogenic activities. Some of these impacts have led to the uncontrolled growth of Pistia stratiotes, an invasive aquatic plant. This study sought to quantify the regulation and provisioning of ecosystem services provided by P. stratiotes using carbon storage and the provision of biomass as indicators. To this end, the biomasses of 50 plots measuring 0.0625 m2 were weighed and georeferenced and the percentages of dry biomass (%DB) and total organic carbon in the biomass (%C) were quantified. The biomass and its coordinates were entered into ArcGIS and a Kriging interpolation technique was applied to determine the total amount of biomass (B). It was found that P. stratiotes stored 3942.57 tCO2 and that 2132.41 tons of biomass could be obtained for fodder. The total carbon stored by this aquatic plant represented 28.46% of the total carbon sequestered in the wetland ecosystem by vascular plants, suggesting that its contribution to the carbon cycle is significant. This is the first study to estimate the biomass of a floating aquatic plant population in a coastal Peruvian wetland and is a pioneering study addressing the in situ carbon estimation of Peruvian floating aquatic plants. The results and methods proposed in this research will serve in the evaluation of the potential of ecosystem services among similar populations of floating aquatic species. In addition, the data presented can be used to establish plans for the management and use of this biomass in the production of soil fertilizers and cattle forage.
Optimising Bioprinting Nozzles through Computational Modelling and Design of Experiments
Authors: Blanco Juan C. Gómez , Macías-García Antonio , Rodríguez-Rego Jesús M. , Mendoza-Cerezo Laura , Sánchez-Margallo Francisco M. , Marcos-Romero Alfonso C. , Pagador-Carrasco José B.
Published: July 2024

3D bioprinting is a promising technique for creating artificial tissues and organs. One of the main challenges of bioprinting is cell damage, due to high pressures and tensions. During the biofabrication process, extrusion bioprinting usually results in low cell viability, typically ranging from 40% to 80%, although better printing performance with higher cell viability can be achieved by optimising the experimental design and operating conditions, with nozzle geometry being a key factor. This article presents a review of studies that have used computational fluid dynamics (CFD) to optimise nozzle geometry. They show that the optimal ranges for diameter and length are 0.2 mm to 1 mm and 8 mm to 10 mm, respectively. In addition, it is recommended that the nozzle should have an internal angle of 20 to 30 degrees, an internal coating of ethylenediaminetetraacetic acid (EDTA), and a shear stress of less than 10 kPa. In addition, a design of experiments technique to obtain an optimal 3D bioprinting configuration for a bioink is also presented. This experimental design would identify bioprinting conditions that minimise cell damage and improve the viability of the printed cells.
Identity Disturbance in the Digital Era during the COVID-19 Pandemic: The Adverse Effects of Social Media and Job Stress
Authors: Obrenovic Bojan , Godinic Danijela , Du Gang , Khudaykulov Akmal , Gan Hui
Published: July 2024

The empirical study aimed to explore the relationships among social media exposure, job stress, anxiety, and identity disturbance in a nonclinical setting in the COVID-19 pandemic context. An online questionnaire was administered to 282 participants in the United States of America (USA) during the COVID-19 pandemic. The study utilized a two-step Structural Equation Modeling (SEM) approach consisting of both measurement model and structural model testing. Relationships between the model variables of social media exposure, identity disturbance, anxiety, and job stress were analyzed using standardized beta coefficients, standard errors, t-values, and p-values. The results indicate that both social media exposure and job stress are associated with increased anxiety levels, which, in turn, influence identity disturbance. Moreover, there is a moderating effect of job stress on the relationship between social media exposure and anxiety, as well as the mediating effect of anxiety on the relationship between social media exposure and identity disturbance. The findings are valuable for organizations and can be used to develop programs aimed at mitigating the adverse effects of social media exposure on mental health. Prioritizing employee mental health through awareness and support initiatives is paramount, especially for those facing high stress and extensive social media use.
The Chain-Mediating Effects of Mindfulness and Sense of Control on Corporate Employees’ Mental Health Problems
Authors: Li Xiaoran , Ni Xiaoli , Zhang Juguo
Published: July 2024

Based on the chain-mediating role of mindfulness and sense of control, this study examines the mediating role of mindfulness and sense of control on employees’ mental health. A total of 720 questionnaires were collected from employees of select enterprises and institutions in China; 53 invalid questionnaires were excluded, with a response rate of 93%, leaving 667 employees as the study sample (average age = 38 years, 71.8% female). The study findings show that: (1) Work–family conflict had a significant positive correlation with mental health problems and a significant negative correlation with mindfulness and sense of control. (2) The influence on the mental health state was due to the mediating effect of mindfulness, sense of control, and the chain-mediating effect of mindfulness and sense of control. The study adopted self-report scales for measuring mindfulness and a sense of control; therefore, further experimental methods must be included in the future to explore these results. This study shows that mindfulness and sense of control can reduce the impact of work–family conflict on mental health problems. Additionally, the chain-mediating effect of mindfulness and sense of control plays an important role in mental health problems.
A Novel Three-Stage Collision-Risk Pre-Warning Model for Construction Vehicles and Workers
Authors: Gan Wenxia , Gu Kedi , Geng Jing , Qiu Canzhi , Yang Ruqin , Wang Huini , Hu Xiaodi
Published: July 2024

Collision accidents involving construction vehicles and workers frequently occur at construction sites. Computer vision (CV) technology presents an efficient solution for collision-risk pre-warning. However, CV-based methods are still relatively rare and need an enhancement of their performance. Therefore, a novel three-stage collision-risk pre-warning model for construction vehicles and workers is proposed in this paper. This model consists of an object-sensing module (OSM), a trajectory prediction module (TPM), and a collision-risk assessment module (CRAM). In the OSM, the YOLOv5 algorithm is applied to identify and locate construction vehicles and workers; meanwhile, the DeepSORT algorithm is applied to the real-time tracking of the construction vehicles and workers. As a result, the historical trajectories of vehicles and workers are sensed. The original coordinates of the data are transformed to common real-world coordinate systems for convenient subsequent data acquisition, comparison, and analysis. Subsequently, the data are provided to a second stage (TPM). In the TPM, the optimized transformer algorithm is used for a real-time trajectory prediction of the construction vehicles and workers. In this paper, we enhance the reliability of the general object detection and trajectory prediction methods in the construction environments. With the assistance afforded by the optimization of the model’s hyperparameters, the prediction horizon is extended, and this gives the workers more time to take preventive measures. Finally, the prediction module indicates the possible trajectories of the vehicles and workers in the future and provides these trajectories to the CRAM. In the CRAM, the worker’s collision-risk level is assessed by a multi-factor-based collision-risk assessment rule, which is innovatively proposed in the present work. The multi-factor-based assessment rule is quantitatively involved in three critical risk factors, i.e., velocity, hazardous zones, and proximity. Experiments are performed within two different construction site scenarios to evaluate the effectiveness of the collision-risk pre-warning model. The research results show that the proposed collision pre-warning model can accurately predict the collision-risk level of workers at construction sites, with good tracking and predicting effect and an efficient collision-risk pre-warning strategy. Compared to the classical models, such as social-GAN and social-LSTM, the transformer-based trajectory prediction model demonstrates a superior accuracy, with an average displacement error of 0.53 m on the construction sites. Additionally, the optimized transformer model is capable of predicting six additional time steps, which equates to approximately 1.8 s. The collision pre-warning model proposed in this paper can help improve the safety of construction vehicles and workers.
Variation in the Modal Response of Retrofitted Unreinforced Masonry Walls at Different Levels of Damage
Authors: Romero-Carrasco Joaquín , Sanhueza-Espinoza Frank , Oyarzo-Vera Claudio
Published: July 2024

This article presents the results of an experimental campaign conducted on a set of four unreinforced masonry walls at full scale. The purpose of this study is to assess, using non-destructive methods, the impact of retrofitting and damage on the modal response of masonry wall systems. Each wall underwent a sequence of increasing cyclic displacements applied by an actuator at the upper end of the specimen. Modal tests based on vibrations were performed both before and after rehabilitation, as well as during the sequence of increasing displacements. It was demonstrated that frequencies can identify progressive damage when the maximum crack is about to occur, as well as the effect of wall retrofitting when mass contribution is considerable. However, the modal assurance criterion indicator (MAC) fails to properly identify a trend of decreasing correlations as progressive damage increases; instead, it is sensitive to detecting maximum crack and instability conditions. Furthermore, it was determined that the coordinated modal assurance criterion indicator (COMAC) does not identify the damage distribution as expected. However, the cumulative COMAC provides a useful tool for quick visualization and interpretation of COMAC behavior. Finally, a novel damage indicator was tested, MACVF, which improves the trend and successfully identifies the most damage-sensitive mode, especially when the maximum level of damage is reached, giving MAC values below 80%. In addition, frequency variations ranged from 70% to 110% when TRM and WWM retrofitting techniques were applied.
Parallelization Strategy for 3D Probabilistic Numerical Cracking Model Applied to Large Concrete Structures
Authors: Rita Mariane Rodrigues , Rossi Pierre , Fairbairn Eduardo de Moraes Rego , Ribeiro Fernando Luiz Bastos , Tailhan Jean-Louis , Andrade Henrique Conde Carvalho de , Mota Magno Teixeira
Published: July 2024

This work presents the application of a finite element model utilizing a three-dimensional (3D) probabilistic semi-explicit cracking model to analyze the rupture process of a large concrete wall beam. The numerical analysis predicts both the global behavior of the structure and its primary rupture mechanisms, utilizing three different finite element mesh refinements to ensure robustness. A Monte Carlo (MC) procedure is integrated into the modeling approach to account for probabilistic variations of the material properties. The statistical analysis derived from this probabilistic model may sometimes result in overly conservative safety coefficients, particularly when using a coarse mesh. Additionally, the detailed understanding of the structure’s cracking process, regardless of its rupture mechanism, may experience some reduction in precision. Due to the necessity of numerous simulations to achieve statistically significant results, the MC procedure can become computationally expensive. To address this, a straightforward parallelization of the Monte Carlo procedure was implemented, allowing multiple finite element analyses to be conducted concurrently. This strategy significantly reduced computational time, thereby enhancing the efficiency of the numerical model in performing numerical simulations of structural engineering.
Reliability Analysis of Degraded Suspenders of Long-Span Suspension Bridge under Traffic Flow Braking
Authors: Zhao Yue , Fu Yingzi , Zhu Yiyun , Su Botong
Published: July 2024

The suspender is a crucial and vulnerable component of large-span cable bridges, and its service performance inevitably degrades under environmentally corrosive media and traffic load. The long loading area of a large-span bridge provides the possibility for continuous traffic flow braking on the bridge. This study proposes a continuous braking model of traffic flow based on the driver’s emergency braking reaction time and a steel wire degradation model considering the stress distribution characteristics of steel wire bending in the cross-section to analyze the safety of degraded cable components. The degradation process and bearing capacity variation of the cable are accurately quantified, and the reliability of the degraded cable under the action of traffic flow braking is determined. The results show that the traffic flow braking action causes a remarkable bending stress response in the bridge cable that reaches 450 MPa, which is much larger than the normal acting time. Moreover, differences in the bending stress of the cross-sectional steel wire cause significant differences in the fatigue process of the steel wire in different layers of the suspender. The outermost steel wires begin to fail after 12 years, and their service life is considerably different from that of the interlayer wires. The severely degraded steel wires on the outside can easily break under the traffic flow braking action, but they have no noticeable effect on the suspender’s ultimate bearing capacity because of the Daniels effect. The increase in the cable force caused by traffic flow braking and the stress redistribution after the steel wires break have the most evident influence on the reliability of the structure. Due to the effects of traffic flow braking, the timing of suspender maintenance is advanced by 8 years.
Research on Integrated Design of Prefabricated Steel Frame Structures Based on BIM Technology with a Focus on Structural Safety
Authors: Wang Pengfei , Wang Xiaofei , Chen Wei , Li Yan , Wang Junguo
Published: July 2024

To address the issue of inconsistencies between the 3D structural models built on Building Information Modeling (BIM) platforms and the original structural designs, thereby ensuring structural safety and reliability, this paper proposes an integrated design approach for prefabricated steel frame structures based on BIM technology with a primary focus on structural safety. The application of the integrated design methodology for prefabricated steel frame structures, leveraging BIM technology, is concretely demonstrated through case studies. These illustrations focus on pivotal aspects: assessing the overall safety performance of the structure, conducting meticulous analyses of beam-to-column connection nodes, and harnessing the outcomes of these evaluations to inform and direct the optimization of the structural design. The research findings presented herein offer insights and methodologies for applying BIM in safety assessments of prefabricated steel frame structures, thereby further refining the comprehensive framework of BIM engagement throughout the entire life cycle of prefabricated steel frame construction projects.
What Does N2 Lymph Node Involvement Mean for Patients with Non-Small Cell Lung Cancer (NSCLC)?—A Review of Implications for Diagnosis and Treatment
Authors: Linares Díaz Julio , Edwards John , Deleu Anne-Leen , Giaj-Levra Niccolo , Prisciandaro Elena , Roch Benoit , Paesmans Marianne , Berghmans Thierry , Brandão Mariana
Published: July 2024

Patients with stage III NSCLC with N2 lymph node involvement carry a complex and diverse disease entity. Challenges persist in the areas of diagnosis, staging, multimodal management, and the determination of surgical indications and resectability criteria. Therefore, this review focuses on the latest updates in N2 disease staging and its prognostic and treatment implications. Emphasis is placed on the importance of accurate staging using imaging modalities such as [18F]FDG-PET/CT as well as minimally invasive mediastinal staging endoscopic techniques. The evolving role of surgery in the management of N2 disease is also explored. The benefits of neoadjuvant and adjuvant treatments have been demonstrated, along with the efficacy of a combined multimodal approach with chemo-immunotherapy in the perioperative setting, reigniting the debate of N2 disease subsets and optimal treatment options. Furthermore, this review addresses the controversies surrounding surgical approaches in upfront “borderline” resectable stage III NSCLC as well as the benefits of combined chemoradiotherapy with consolidation immunotherapy for patients with unresectable tumors. In conclusion, personalized diagnostic and treatment approaches tailored to individual patient characteristics, resource availability, and institutional expertise are essential for optimizing outcomes in patients with stage III-N2 NSCLC.
The Landscape of Stereotactic Ablative Radiotherapy (SABR) for Renal Cell Cancer (RCC)
Authors: Moreno-Olmedo Elena , Sabharwal Ami , Das Prantik , Dallas Nicola , Ford Daniel , Perna Carla , Camilleri Philip
Published: July 2024

Renal cell cancer (RCC) has traditionally been considered radioresistant. Because of this, conventional radiotherapy (RT) has been predominantly relegated to the palliation of symptomatic metastatic disease. The implementation of stereotactic ablative radiotherapy (SABR) has made it possible to deliver higher ablative doses safely, shifting the renal radioresistance paradigm. SABR has increasingly been adopted into the multidisciplinary framework for the treatment of locally recurrent, oligoprogressive, and oligometastatic disease. Furthermore, there is growing evidence of SABR as a non-invasive definitive therapy in patients with primary RCC who are medically inoperable or who decline surgery, unsuited to invasive ablation (surgery or percutaneous techniques), or at high-risk of requiring post-operative dialysis. Encouraging outcomes have even been reported in cases of solitary kidney or pre-existing chronic disease (poor eGFR), with a high likelihood of preserving renal function. A review of clinical evidence supporting the use of ablative radiotherapy (SABR) in primary, recurrent, and metastatic RCC has been conducted. Given the potential immunogenic effect of the high RT doses, we also explore emerging opportunities to combine SABR with systemic treatments. In addition, we explore future directions and ongoing clinical trials in the evolving landscape of this disease.
Insights into Dysregulated Neurological Biomarkers in Cancer
Authors: Duranti Elisa , Villa Chiara
Published: July 2024

The link between neurodegenerative diseases (NDs) and cancer has generated greater interest in biomedical research, with decades of global studies investigating neurodegenerative biomarkers in cancer to better understand possible connections. Tau, amyloid-β, α-synuclein, SOD1, TDP-43, and other proteins associated with nervous system diseases have also been identified in various types of solid and malignant tumors, suggesting a potential overlap in pathological processes. In this review, we aim to provide an overview of current evidence on the role of these proteins in cancer, specifically examining their effects on cell proliferation, apoptosis, chemoresistance, and tumor progression. Additionally, we discuss the diagnostic and therapeutic implications of this interconnection, emphasizing the importance of further research to completely comprehend the clinical implications of these proteins in tumors. Finally, we explore the challenges and opportunities in targeting these proteins for the development of new targeted anticancer therapies, providing insight into how to integrate knowledge of NDs in oncology research.
A Mature Tertiary Lymphoid Structure with a Ki-67-Positive Proliferating Germinal Center Is Associated with a Good Prognosis and High Intratumoral Immune Cell Infiltration in Advanced Colorectal Cancer
Authors: Mori Natsumi , Dorjkhorloo Gendensuren , Shiraishi Takuya , Erkhem-Ochir Bilguun , Okami Haruka , Yamaguchi Arisa , Shioi Ikuma , Komine Chika , Endo Mizuki , Seki Takaomi , Hosoi Nobuhiro , Nakazawa Nobuhiro , Shibasaki Yuta , Okada Takuhisa , Osone Katsuya , Sano Akihiko , Sakai Makoto , Sohda Makoto , Yokobori Takehiko , Shirabe Ken , Saeki Hiroshi
Published: July 2024

Tertiary lymphoid structures (TLSs) are complex lymphocyte clusters that arise in non-lymphoid tissues due to inflammation or cancer. A mature TLS with proliferating germinal centers is associated with a favorable prognosis in various cancers. However, the effect of TLS maturity on advanced colorectal cancer (CRC) remains unexplored. We analyzed the significance of TLS maturity and tumor Ki-67 expression in surgically resected tumors from 78 patients with pathological T4 CRC. Mature TLS was defined as the organized infiltration of T and B cells with Ki-67-positive proliferating germinal centers. We analyzed the relationship between TLS maturity and intratumoral immune cell infiltration. Mature TLS with germinal center Ki-67 expression was associated with microsatellite instability and improved survival; however, high tumor Ki-67 expression was associated with poor survival in the same cohort. Multivariate analysis identified the absence of mature TLS as an independent predictor of poor post-recurrence overall survival. Intratumoral infiltration of T lymphocytes and macrophages was significantly elevated in tumors with mature TLS compared to those lacking it. High Ki-67 levels and absent mature TLS were identified as poor prognostic factors in advanced CRC. Mature TLS could serve as a promising marker for patients at high-risk of CRC.
Application of Ultraviolet-Enhanced Fluorescence Dermoscopy in Basal Cell Carcinoma
Authors: Wojtowicz Irena , Żychowska Magdalena
Published: July 2024

Introduction: Basal cell carcinoma (BCC) is the most common non-melanoma skin cancer. The aim of the current study was to analyze the ultraviolet-enhanced fluorescence dermoscopy (UVFD) characteristics of BCCs. Methods: BCCs were evaluated under polarized dermoscopy (PD) and UVFD. The findings in PD were described using predefined parameters for dermoscopic evaluation in dermato-oncology. UVFD characteristics were determined based on personal observations, and included interrupted follicle pattern, absence of pink-orange or blue-green fluorescence, well-demarcated borders, and dark silhouettes. Results: In total, 163 BCCs were analyzed. Under UVFD, the interrupted follicle pattern (p < 0.001), absence of pink-orange fluorescence (p = 0.005) and well-demarcated borders (p = 0.031) were more frequently noted in BCCs < 5 mm than in bigger tumors. Lesions on the face showed clearly defined borders (p = 0.031) and interrupted follicle pattern (p < 0.001) more frequently than tumors located beyond the face. Nodular BCCs displayed interrupted follicle pattern (p = 0.001) and absence of pink-orange fluorescence (p < 0.001) more commonly than superficial subtypes. Non-pigmented BCCs more frequently showed lack of blue-green fluorescence (p = 0.007) and interrupted follicle pattern (p = 0.018) compared to pigmented variants. Conclusions: UVFD may be a valuable, complementary to PD, tool in the diagnosis of BCC, particularly in small tumors, lesions located on the face and nodular or non-pigmented subtypes.
Calcium-Based Imaging of the Spine at Dual-Layer CT and Evaluation of Vertebral Fractures in Multiple Myeloma
Authors: Brandelik Simone C. , Rahn Stefanie , Merz Maximilian , Stiller Wolfram , Skornitzke Stephan , Melzig Claudius , Kauczor Hans-Ulrich , Weber Tim F. , Do Thuy D.
Published: July 2024

Purpose: To evaluate the prediction of vertebral fractures in plasma cell dyscrasias using dual-layer CT (DLCT) with quantitative assessment of conventional CT image data (CI), calcium suppressed image data (CaSupp), and calculation of virtual calcium-only (VCa) image data. Material and Methods: Patients (n = 81) with the diagnosis of a plasma cell dyscrasia and whole-body DLCT at the time of diagnosis and follow-up were retrospectively enrolled. CI, CaSupp25, and CaSupp100 were quantitatively analyzed using regions of interest in the lumbar vertebral bodies and fractured vertebral bodies on baseline or follow-up imaging. VCa were calculated by subtraction (CaSupp100-CaSupp25), delineating bone only. Logistic regression analyses were performed to assess the possibility of imminent spine fractures. Results: In 24 patients, new vertebral fractures were observed in the follow-up imaging. The possibility of new vertebral fractures was significant for baseline assessment of CT numbers in CI, CaSupp25, and VCa (p = 0.01, respectively), with a higher risk for new fractures in the case of lower CT numbers in CI (Odds ratio = [0.969; 0.994]) and VCa (Odds ratio = [0.978; 0.995]) and in the case of higher CT numbers in CaSupp 25 (Odds ratio 1.015 [1.006; 1.026]). Direct model comparisons implied that CT numbers in CaSupp 25 and VCa might show better fracture prediction than those in CI (R2 = 0.18 both vs. 0.15; AICc = 91.95, 91.79 vs. 93.62), suggesting cut-off values for CI at 103 HU (sensitivity: 54.2%; specificity: 82.5; AUC: 0.69), for VCa at 129 HU (sensitivity: 41.7%; specificity: 94.7; AUC: 0.72). Conclusions: Quantitative assessment with CaSupp and calculation of VCa is feasible to predict the vertebral fracture risk in MM patients. DLCT may prove useful in detecting imminent fractures.
Adjuvant Therapy for High-Risk Stage II Melanoma: Current Paradigms in Management and Future Directions
Authors: Vargas Gracia Maria , Farooq Mohammad Saad , Karakousis Giorgos C.
Published: July 2024

Melanoma is the fifth most common cancer in the United States and accounts for the majority of all skin cancer-related deaths, making it the most lethal cutaneous malignancy. Systemic adjuvant therapy for stage IIB-IV melanoma is now approved for patients who have undergone surgical resection, given the appreciable risk of recurrence and mortality in this patient population. Despite the lower stage, high-risk stage II melanoma (stage IIB/IIC) can often exhibit an even more aggressive course when compared to stage IIIA/IIIB disease, thus justifying consideration of adjuvant therapy in these patients. In this review, we highlight the current standard of practice for the treatment of stage IIB/C melanoma, with a focus on adjuvant therapies supported by published landmark clinical trials, including anti-PD-1 therapy. Notably, adjuvant therapies approved thus far in this patient population have demonstrated an improvement in recurrence-free survival, while their impact on overall survival is pending. Finally, this review highlights currently ongoing trials and future directions for research and treatment possibilities for high-risk clinical stage II melanoma.
Emerging Therapeutic Targets and Future Directions in Advanced Gastric Cancer: A Comprehensive Review
Authors: Ratti Margherita , Orlandi Elena , Toscani Ilaria , Vecchia Stefano , Anselmi Elisa , Hahne Jens Claus , Ghidini Michele , Citterio Chiara
Published: July 2024

Metastatic gastric cancer (GC) still represents a critical clinical challenge, with limited treatment options and a poor prognosis. Most patients are diagnosed at advanced stages, limiting the chances of surgery and cure. The identification of molecular targets and the possibility of combining immune checkpoint inhibitors with chemotherapy have recently reshaped the therapeutic landscape of metastatic gastric cancer. The new classification of gastric cancer, mainly based on immunologic and molecular criteria such as programmed cell death 1 (PD-1), microsatellite instability (MSI), and human epidermal growth factor receptor 2 (HER2), has made it possible to identify and differentiate patients who may benefit from immunotherapy, targeted therapy, or chemotherapy alone. All relevant and available molecular and immunological targets in clinical practice for the systemic treatment of this disease are presented. Particular attention is given to possible future approaches, including circulating tumor DNA (ctDNA) for therapeutic monitoring, new targeting agents against molecular pathways such as fibroblast growth factor receptor (FGFR) and MET, chimeric antigen receptor (CAR)-T cells, and cancer vaccines. This review aims to provide a comprehensive understanding of current targets in advanced gastric cancer and to offer valuable insights into future directions of research and clinical practice in this challenging disease.
Performance of Contrast-Enhanced Mammography (CEM) for Monitoring Neoadjuvant Chemotherapy Response among Different Breast Cancer Subtypes
Authors: Vidali Sofia , Irmici Giovanni , Depretto Catherine , Bellini Chiara , Pugliese Francesca , Incardona Ludovica Anna , Di Naro Federica , De Benedetto Diego , Di Filippo Giacomo , Ferraro Fabiola , De Berardinis Claudia , Miele Vittorio , Scaperrotta Gianfranco , Nori Cucchiari Jacopo
Published: July 2024

Neoadjuvant chemotherapy (NAT) plays a crucial role in breast cancer (BC) treatment, both in advanced BC and in early-stage BC, with different rates of pathological complete response (pCR) among the different BC molecular subtypes. Imaging monitoring is mandatory to evaluate the NAT efficacy. This study evaluates the diagnostic performance of Contrast-Enhanced Mammography (CEM) in BC patients undergoing NAT. This retrospective two-center study included 174 patients. The breast lesions were classified based on the molecular subtypes in hormone receptor (HR+)/HER2−, HER2+, and triple-negative breast cancer (TNBC). The histopathological analysis performed following surgery was used as a reference standard for the pCR. Sensitivity, specificity, PPV, and NPV were measured overall and for the different subtypes. We enrolled 174 patients, 79/174 (46%) HR+/HER2−, 59/174 (33.9%) HER2+, and 35/174 (20.1%) TNBC; the pCR was found in 64/174 (36.8%), of which 57.1% were TNBCs. In the total population, the CEM sensitivity and specificity were 66.2% and 75.2%, with a PPV of 61.4% and an NPV of 78.8%. The highest specificity (80.9%) and NPV (91.7%) were found in HR+/HER2−, while the highest sensitivity (70%) and PPV appeared (73.7%) in TNBC. The results indicate that CEM is a valid tool to assess the pCR, with different performances among the subtypes of BC.
Predictive and Prognostic 18F-Fluorocholine PET/CT Radiomics Nomogram in Patients with Castration-Resistant Prostate Cancer with Bone Metastases Treated with 223Ra
Authors: Cruz-Montijano Marcos , Amo-Salas Mariano , Cassinello-Espinosa Javier , García-Carbonero Iciar , Villa-Guzman Jose Carlos , Garcia-Vicente Ana Maria
Published: July 2024

Purpose: We aimed to develop a nomogram able to predict treatment failure, skeletal events, and overall survival (OS) in patients with castration-resistant prostate cancer with bone metastases (CRPC-BM) treated with Radium-223 dichloride (223Ra). Patients and Methods: Patients from the Castilla-La Mancha Spanish region were prospectively included in the ChoPET-Rad multicenter study from January 2015 to December 2022. Patients underwent baseline, interim, and end-of-treatment bone scintigraphy (BS) and 18F-Fluorocholine PET/CT (FCH PET/CT) scans, obtaining multiple imaging radiomics as well as clinical and biochemical variables during follow-up and studying their association with the previously defined end-points. Survival analysis was performed using the Kaplan–Meier method and Cox regression. Multivariate logistic and Cox regression models were calculated, and these models were depicted by means of nomograms. Results: Median progression-free survival (PFS) and OS were 4 and 14 months (mo), respectively. The variables that showed independent and significant association with therapeutic failure were baseline alkaline phosphatase (AP) levels (p = 0.022) and the characteristics of BM on the CT portion of PET/CT (p = 0.017). In the case of OS, the significant variables were therapeutic failure (p = 0.038), the number of lines received after 223Ra (p < 0.001), average SUVmax (p = 0.002), bone marrow infiltration in FCH PET/CT (p = 0.006), and interim FCH PET/CT response (p = 0.048). Final nomograms included these variables, showing good discrimination among the 100 patients included in our study. In the study of skeletal events, only OS showed a significant association in the multivariate analysis, resulting in an inconsistent nomogram design. Conclusions: FCH PET/CT appears to be a good tool for evaluating patients eligible for treatment with 223Ra, as well as for their follow-up. Thus, findings derived from it, such as the morphological characteristics of BM in the CT, bone marrow infiltration, or the response to 223Ra in the interim study, have proven to be solid and useful variables in the creation of nomograms for predicting therapeutic failure and OS.