bluuebunny/crossref_metadata_2025 huggingface dataset:
Curcumin: a potent anti-inflammatory agent for the management of chronic inflammatory diseases
Authors: Borkar Natasha Nitin , Devade Priyanka Bhalchandra , Chavan Nakshatra Rakesh , Dhaygude Vaishani Narhari , Kshrisagar Sakshi Prakash , Pawar Shraddha
Published: December 2024

Chronic inflammation plays a critical role in the progression of several debilitating conditions, including diabetes, cancer, cardiovascular diseases, neurological disorders, and autoimmune diseases. As a result, targeting inflammation has become a key therapeutic approach for managing these diseases. Curcumin, a bioactive compound derived from turmeric (Curcuma longa), has garnered significant interest due to its potent anti-inflammatory and antioxidant properties.Curcumin exerts its effects by modulating various molecular pathways involved in inflammation, including the downregulation of pro-inflammatory cytokines and transcription factors such as NF-?B. Its ability to inhibit oxidative stress further enhances its therapeutic potential. Preclinical and clinical studies have shown promising results in the use of curcumin for managing inflammatory conditions like arthritis, inflammatory bowel disease, and metabolic syndrome.Despite its potential, curcumin’s clinical applicability is limited by its low bioavailability, which has led to the development of novel delivery systems such as nanoparticles, liposomes, and curcumin analogs to enhance absorption and efficacy.This review aims to summarize the current evidence on curcumin’s anti-inflammatory properties and its medical applications, highlighting its role as a natural and safe therapeutic agent for combating chronic inflammatory diseases. Future research is warranted to further optimize its clinical efficacy and formulations.
Assessment of Language Impairment Management of Post Stroke at Erbil Public Hospitals
Authors: Azad Hassan Kheder  , Najat Muhammed Amin Mawlood
Published: December 2024

Background: Stroke is the most common cause of aphasia which need to be managed because it postpones stroke recovery and causes psychological and social problems for the patients and their families. Researchers have observed that the issue of language disorder in post-stroke patients has been poorly addressed in Kurdistan Region.
Objective: This neurolinguistic study aims at presenting a comprehensive scale study about the demography of stroke and aphasic patients at Rizgary hospital over a period of TWO months in2024.
Patients and Methods: This cross-sectional study is carried out at Rizgary Public hospital in Erbil-Kurdistan Region.  Demographic for all the patients who were registered at Erbil hospitals during the TWO months in 2024. Then the process of diagnosing aphasia and dysarthria as language impairments are carried out. 
Results: Among 234 subjects, the mean age of post stroke patients is 33.4 ± 22.038001years .15.3% of patients were not paralyzed, meanwhile 44.8% got right side body paralysis, followed by left side 38%, and both side 1.7%. The highest risk factor is Hypertension (68.8%), followed by Diabetes mellitus (41.4%), and Ischemic heart disease (21.7%).
Conclusion: Language disorders is about (71.4%) which is a high range among post-stroke patients. Language disorders does not only affect stroke management but it also impair the individual’s quality of life. If language impairments are screened earlier in patients, it is possible to intervene in language skills and work through speech therapy.
Keywords: Language impairment, stroke, dysarthria.
CONSTRUCTOS DE UMA DEFINIÇÃO PARA ANSIEDADE MATEMÁTICA: REVISÃO INTEGRATIVA DE LITERATURA
Authors: Reis Joanderson de Almeida , Holanda Francisca Helena de Oliveira , Barroso Maria Cleide da Silva , Ferreira Junior Lucelindo Dias
Published: December 2024

A aprendizagem matemática pode ser dificultada por vários fatores (cognitivo, fisiológico e comportamental) que estão atrelados à Ansiedade Matemática. Este artigo, tem por propósito trazer definições sobre a Ansiedade Matemática, obtidas de uma revisão integrativa, com a intenção de identificar as principais dimensões/constructos, que a caracterizam. Os artigos base foram obtidos na plataforma Google Scholar, publicados em periódicos abertos e em língua portuguesa. Para a realização do levantamento da literatura foi utilizado o descritor  “ansiedade matemática”, considerando um recorte temporal de aproximadamente 5 anos, de 2019 a 2024, e o acesso aberto à publicação. Foram identificados 51 trabalhos, reduzidos pela leitura do título, resumo e palavras-chave, a 18 publicações. Como resultado, foi possível definir a Ansiedade matemática a partir de seis dimensões/constructos: (1) experiência subjetiva; (2) sujeito; (3) objeto; (4) estímulo; (5) reação frente ao estímulo; e, (6) agentes interferentes. Foi observado que há uma miríade de conceitos que nem sempre se tangenciam, indicando que a sociedade, docentes e pais podem ser agentes interferentes, ocasionando experiências subjetivas como aversão, tensão e medo ao estímulo da matemática, que implicam em ações de fuga, autorregras autodepreciativas frente às situações, estímulos, que envolvam matemática, seja na vida acadêmica ou em situações cotidianas não ligadas ao ensino.
APRENDIZAGEM DE MATEMÁTICA NA PERSPECTIVA DA NEUROCIÊNCIA: UM PANORAMA DE PESQUISAS (2019 a 2023)
Authors: Andrade Roniely Araújo Balacol , Lima Reinaldo Feio
Published: December 2024

O ensino de matemática na perspectiva da Neurociência cognitiva é um tema que vem ganhando relevância nas últimas décadas e gerando impactos na literatura, sendo uma área que estuda o sistema nervoso central aplicada ao ensino visando compreender como ocorre a aprendizagem. Este trabalho tem como objetivo discorrer sobre as contribuições da Neurociência no entendimento dos principais aspectos e regiões cerebrais envolvidos na aprendizagem de matemática. A pesquisa se justifica pelo fato de ao compreender melhor os processos neurais envolvidos na aprendizagem de matemática, os educadores poderão desenvolver estratégias alinhadas às características naturais do cérebro. Utilizamos uma abordagem qualitativa de tipo bibliográfico por permitir uma ampla revisão da literatura sobre o tema de interesse, trazendo as principais abordagens, métodos e resultados encontrados pelos autores estudados. As pesquisas do corpus demostram os preceitos da Neurociência, considerando o cérebro como o lugar onde acontecem as mudanças para a aprendizagem. Além disso, a Neurociência aplicada à educação não se mostra uma nova pedagogia para substituir as existentes e nem a solução para todos os problemas da aprendizagem, mas agrega ainda mais cientificidade e embasamento às teorias pedagógicas existentes.
CONTEXTO E CONCRETIZAÇÃO DE ENUNCIADOS: IMPLICAÇÕES PARA PRODUÇÃO ACADÊMICA EM EDUCAÇÃO MATEMÁTICA
Authors: Almeida José Joelson Pimentel de , Rodrigues Grygena dos Santos Targino
Published: December 2024

Este artigo, de natureza teórica, trata de uma discussão sobre contextualização e enunciado, assim como suas implicações para atividades de pesquisa e para a produção acadêmica, principalmente a escrita de teses e dissertações. Tem por objetivo situar, em uma perspectiva crítica, os conceitos de contextualização e enunciado no âmbito da pesquisa em sala de aula, considerando-se a concretização dos enunciados e as relações de continuidade das ações ocorridas no ambiente de pesquisa. Partimos da ideia de que toda atividade é contextualizada, restando analisar se o contexto é adequado conforme as dimensões do que se propõe na atividade. Outro pressuposto, é que o contexto é sempre circunstanciado, assim, o estabelece uma relação entre o enunciado, tal qual pensado por seu locutor, e a sua concretização. Ou seja, depende das condições enunciativas dessa concretização. Temos Bakhtin como referencial teórico no que se refere aos constructos teóricos advindos da Linguística, caminhando  para uma discussão principalmente a partir da concretização de enunciados em Educação Matemática, mas não limitando-se a este campo de investigação. Concluímos que o contexto também implica em uma relação entre o discurso e a ação política envolvidos. Desta forma, cabe ao pesquisador, em sua produção textual, inclusive na composição de teses e dissertações, uma circunspeção nas descrições das condições enunciativas e no tratamento e análise dos dados de sua pesquisa, em especial, um cuidado e um respeito aos participantes da pesquisa.
Nutilor (Moringa Leaf and Chicken Liver Nuggets) as Food for Stunting Prevention
Authors: Bertalina Bertalina , Sirajudin Sirajudin
Published: December 2024

Providing complementary foods for breast milk (MP-ASI) is very important because the age of >6 months to 2 years, nutrients are needed to support children's growth and development during the golden period. Nuggets are a high-protein food. Modifications were made to increase the nutritional value by adding chicken liver and Moringa leaves and substituting them with Nutilor (Moringa Leaf Liver Nuggets). The research aims to analyze panelists' nutritional value and acceptability regarding the color, aroma, taste, and texture aspects of Nutilor products, as well as knowing market analysis and product prices. The method was an experiment conducted in the Food Laboratory, Nutrition Department, Poltekkes Kemenkes Tanjung Karang. Nutilor with chicken liver substitution, namely: F1 (14%), F2 (16%), F3 (18%), F4 (20%). Organoleptic testing using the hedonic test method (color, aroma, taste, texture, and overall acceptability) was conducted with 75 panelists and one replication. The most preferred Nutilor products are analyzed for their nutritional content, determining food costs and selling prices. Data were analyzed univariately using the Likert scale method. The organoleptic test results showed that the most preferred formula was F3 (90:25), with a nutritional value per serving (60 grams), namely E 171.2 kcal, P 9.1 g, L 8.2 g, KH 16.1, fiber 0.16, iron (Fe) 2.6 mg, the selling price per portion is IDR. 5000. The preferred product is F3, and based on the Likert scale, each formula has different colors and aromas. In further research, you need to pay attention to the time and temperature when frying and measure the amount of lemon used during marination.
Development of instant jelly powder from elephant foot yam (Amorphophallus oncophyllus) and roselle (Hibiscus sabdariffa L.) as a functional food for diabetes mellitus patients
Authors: Ruskim J. , Watung Y.L.G. , Aprilia S.R. , Faizah S. , Dewi A.D.R. , Setiawan F.
Published: December 2024

Elephant foot yam (Amorphophallus oncophyllus) is one of Indonesia’s most widely
grown agricultural commodities. It has a myriad of benefits, especially as a functional
food for people with diabetes mellitus. Roselle (Hibiscus sabdariffa L.) is a flowering
herb rich in polyphenols and anthocyanins with antioxidant and antidiabetic potentials.
Therefore, the aim of this study was to create a functional food that is suitable for diabetes
mellitus patients. In this study, a functional food product in the form of instant jelly
powder was developed from the yam and roselle. Glucomannan extract, obtained from the
yam flour by leaching, was tested using a Fourier-transformed infrared (FTIR)
spectrophotometer (qualitative) and determined the content. Three formulas with different
amounts of glucomannan and iota carrageenan were developed to determine the most
optimized formulation. The most optimized formulation was determined based on
organoleptic characteristics and the results of the gel strength and hardness, total phenolic
content (TPC), and antioxidant activity tests using the ABTS (2,2'-azino-bis(3
ethylbenzothiazoline-6-sulfonic acid) assay. Glucomannan extraction produced a 92.40%
yield, with 46.32% glucomannan content. The spectrophotometric analysis indicated the
presence of glucomannan in the extract, and further tests showed it increased with the
decrease in gel strength and hardness. It was found that formula I produced the best jelly
texture with a total phenolic content of 0.30% GAE (formula II 0.13% GAE; formula III
0.27% GAE) and an ABTS radical scavenging activity of 90.51% (II: 73.49%; III:
88.16%). In conclusion, formula I containing 6.35 g of carrageenan, 2.12 g glucomannan,
1.5 g roselle, 0.03 g citric acid, and 0.003 g sucralose has the best composition to create
the most elastic and firm jelly texture with the highest phenolic content and radical
scavenging activity.
Research Progress on the Composition of Cerebral Arterial Thrombus in Acute Ischemic Stroke
Authors: Wu Xupeng , Wang Shaoshuai , Li Changxin , Liu Hong
Published: December 2024

Acute cerebral infarction, with a high incidence, disability, and recurrence rate, has brought a huge social burden to China and other countries. Understanding the pathological characteristics of cerebral thrombus can help in the selection of individualized treatment plans, thereby improving the good prognosis rate and reducing the recurrence rate of cerebral infarction patients. This article reviews the composition and imaging characteristics of cerebral thrombus, the relationship between cerebral thrombus composition and cerebral vascular recanalization therapy, the correlation between cerebral thrombus composition and the etiology of cerebral infarction, and the dynamic evolution of cerebral thrombus, to provide a more theoretical basis for the treatment of acute ischemic stroke.
Effectiveness of a High-risk Fall Care Program based on the “Safety-support-collaboration” Model in a Neurology Department
Authors: Zhao Shuhui , Hu Manhui
Published: December 2024

Objective: To analyze the effect of the high-risk fall care program based on the “safety-support-cooperation” model in neurological profound. Methods: 80 patients who were admitted to the Department of Neurology from December 2021 to December 2023 were randomly divided into an observation group and a control group, and were treated with conventional nursing care and conventional + “safety-supportive-cooperative” nursing care program for high-risk falls, respectively. The effects of the two groups were evaluated. Results: After the nursing care, the patients’ fall prevention self-management ability was stronger, and the scores of each dimension were higher, P < 0.05. After the nursing care, the fall risk of the observation group was relatively lower, P < 0.05, and the incidence rate of falls in the observation group was lower, P < 0.05. Conclusion: In the nursing care of neurological patients, based on the “safety-support-cooperation” model, it is possible to establish a high-risk fall nursing care program, which is based on “safety-support-cooperation.” Conclusion: The establishment of a high-risk fall care program based on the “safety-support-cooperation” model in the care of neurological patients can help improve patients’ self-management ability, reduce the incidence of falls, and improve patient safety.
The Effectiveness of Neurological Rehabilitation Therapy in Improving Motor Function and Daily Living Abilities in Stroke Patients with Hemiplegia
Authors: Jia Haiyu
Published: December 2024

Objective: To explore the effects of neurological rehabilitation therapy on motor function and daily living abilities in stroke patients with hemiplegia. Methods: Fifty stroke patients with hemiplegia admitted to the hospital were randomly divided into an observation group and a control group, with 25 patients in each group. The control group received conventional rehabilitation therapy, while the observation group underwent additional neurological rehabilitation therapy. The therapeutic effects were compared between the two groups. Results: Post-treatment results showed that the observation group achieved significantly better recovery in motor function, balance ability, and daily living abilities compared to the control group, with a lower incidence of complications during the rehabilitation period. Conclusion: Adding neurological rehabilitation therapy during the rehabilitation period of stroke patients with hemiplegia can effectively enhance recovery outcomes.
The Role Positioning and Survival Status of “Contractor” Style Curators in Contemporary China
Authors: Li Yuanyuan
Published: December 2024

In the context of the thriving development of contemporary art, the curators’ authority in exhibitions is increasingly strengthened, leading to a growing demand for professionals in art curation. The number of curators continues to rise, and their status and role within the art ecosystem are widely acknowledged. However, the working environment and conditions for contemporary art curators in China are not optimistic. Their development has not been as ideal as expected, with both subjective and objective issues and contradictions present. In light of the various problems and contradictions facing the curator community in China, it is essential to conduct an in-depth analysis of these issues to gain a clear understanding of the art curation industry and to truly respect the work of art curators.
Teaching Reform of Interior Furnishing Design Course Based on Traditional Culture in the Perspective of Aesthetic Education
Authors: Han Xiao , Li Yujie
Published: December 2024

In the teaching of interior furnishing design courses, the integration of traditional culture is one of the most important things, which not only helps to improve the students’ aesthetic literacy, but also promotes the inheritance and promotion of traditional culture, and achieves the effect of improving the quality and level of teaching. Therefore, the promotion of interior decoration design teaching from the perspective of aesthetic education needs to deeply integrate traditional culture to improve students’ design ability and cultural identity on this basis and achieve the purpose of improving the quality and effect the teaching reform. Hence, in the paper, the value connotation of aesthetic education is deeply analyzed and researched, the significance of integrating traditional culture into the teaching of interior furnishing design courses is explored, and corresponding teaching countermeasures are put forward according to the challenges faced, to help strengthen the quality of education in interior furnishing design courses and enhance the effectiveness of talent cultivation.
Immersive Experience and Cultural Inheritance: Museum Exhibition Design Based on Metaverse Technology
Authors: Liu Hailong
Published: December 2024

Based on the current status of museum operations and exhibition display schemes, this paper constructs museum exhibition methods and design proposals utilizing metaverse technology through its innovation and optimization. Further discussions are conducted on the characteristics of metaverse technology and its application strategies, providing novel possibilities for the promotion and content dissemination of museum products.
Analysis of China’s New Energy Vehicle Export Competitiveness in a Dual-Carbon Context
Authors: Mei Yuping , Dong Qianqian
Published: December 2024

In the context of the dual-carbon goals (carbon peaking and carbon neutrality), China’s new energy vehicle industry, as a key component of the green economy, has increasingly attracted international attention for its export competitiveness. Drawing on the Porter Diamond Model, this paper selects four major variables—R&D investment, production factors, demand factors, and spare parts services—to establish a linear regression equation. Through this model, the trade competitiveness of China’s new energy vehicles is analyzed in detail, and corresponding suggestions are proposed to enhance the competitiveness index. It is anticipated that Chinese new energy vehicle enterprises can strengthen overseas competitiveness by advancing core technology innovation, improving comprehensive industrial chain management, and diversifying sales channels.
PROGNOSTIC ROLE OF NEUROHUMORAL AND EPIGENETIC MARKERS IN THE FORMATION OF PHENOTYPIC MANIFESTATIONS OF HYPERTROPHIC CARDIOMYOPATHY
Authors: A.V. Vysokikh , V.Y. Kaplunova , G.A. Shakaryants , E.I. Tashina , E.V. Privalova , Y.N. Belenkov
Published: December 2024

At the present time, the problem of studying hypertrophic cardiomyopathy (HCM) remains relevant due to the severity of this disease and the high risk of sudden cardiac death in the population, in particular in young and working age population, which can often be the first and only manifestation of this pathology. Consequently, the search for additional methods of early diagnosis and the development of tools for predicting the course of the disease remain priority areas of research in cardiology. Modern fundamental and clinical studies conducted all over the world are mostly focused on the search for relevant and accessible biomarkers in clinical practice of a doctor, among which special attention is paid to neurohumoral and epigenetic markers, which can be closely related to the possible outcome, the variant of the course of HCM in a patient, as well as can correlate with certain morphometric parameters according to the instrumental methods of examination and clinical picture, which in turn will later serve as a basis for a patient's personalised approach. These studies offer significant prospects for a patient personalised approach. Our review of the current literature on this topic is devoted to the analysis of current trends in cardiology, in particular, in the possible diagnosis and prognostic role of the course of HCM on the basis of neurohumoral and epigenetic markers. Particular attention is paid to the evaluation of the role of miR-29a and TGF-β 1 in patients with different variants of the course of HCM.
TO STUDY THE STABILITY OF THE MAIN QUALITY INDICATORS OF AN EMULSION VACCINE AGAINST THE H5N1 INFLUENZA VIRUS
Authors: V.A. Chakhirova , D.V. Kompantsev , A.A. Chakhirova
Published: December 2024

Modern inactivated emulsion vaccine preparations against avian viral diseases are complex multicomponent immunobiological preparations consisting of a dispersed phase represented by inactivated viruses in combination with an oil adjuvant. The dispersed medium is an oil adjuvant containing as a base highly purified mineral oil in combination with an emulsifier, a surfactant having bipolar molecules with a unique ability to dissolve in both oil and aqueous solutions. Obtaining a stable emulsion from a dispersed medium and phase is possible using modern technological techniques, equipment and high-tech methods. Depending on the manufacturing technology, storage and transportation conditions, inactivated vaccine preparations with an emulsion of the reverse type may have different physical states of the emulsion, which significantly affect their immunobiological properties. Physical changes associated with technological processes during the manufacture and storage of the drug in emulsions of the "water-oil" type can be reversible and irreversible. The purpose of the study was to determine compliance with the standards of the SRT, the most significant quality indicators of the developed inactivated emulsion vaccine preparations that are used in the fight against avian influenza, during storage. The article presents the test results of 3 samples of the developed inactivated emulsion vaccines against the H5N1 avian influenza virus. During 24 months of storage, at specified time intervals, the main quality indicators of the developed vaccine preparations were determined. It was found that the stability and viscosity of the developed emulsion preparations practically did not change relative to the initial standard standards for 24 months. There was also no increase in reactogenicity.
THE EFFECTIVENESS OF PROSTHETIC TREATMENT USING OSSTEM IMPLANTS WITH AN ULTRA-HYDROPHILIC TS SOI SURFACE (The results of our own research)
Authors: A.V. Mikhalchenko , V.N. Naumova , T.V. Kolesova , E.G. Dorozhkina , L.N. Denisenko
Published: December 2024

The relevance of dental rehabilitation of individuals with partial absence of teeth by dental implantation is due to the widespread prevalence of secondary adentia and the high need of the working population for restoration of chewing function and aesthetics. Treatment of the intraosseous part of the implant surface is of great importance for the process of implant osseointegration. This paper analyzes the results of prosthetics using Osstem implants in the TS SOI modification. The ultrahydrophilic rough surface of the implants of the new modification has an increased ability to attract blood and form a blood clot over the entire surface, which contributes to stable osseointegration. One of the criteria for successful treatment is the percentage of implant survival. For 173 Osstem TS SOI implants included in the study, the survival rate was 98%. The second parameter evaluated was peri-implant bone loss. Cone beam computed tomography did not reveal any foci of low bone density around the implant or bone loss at mid- and late follow-up periods of 6 and 12 months. The third evaluation criterion was implant stability. The Osstell measuring device (Osstell AB, Gothenburg, Sweden) was used for the analysis. The average primary stability of Osstem implants with the ultrahydrophilic TS SOI surface was 68.2±7.4, the average secondary stability was 74.0±5.6. The high index of biological stability of the implant in the early stages contributes to a significant decrease in the incidence of complications and a reduction in the treatment time. The formation of biological stability of the Osstem TS SOI implant with the ultrahydrophilic surface occurs within 4-5 weeks. Thus, the use of Osstem implants with the TS SOI surface contributes to an increase in the quality of implant treatment in accordance with the protocol of direct prosthetics and immediate functional loading.
СПИН-КРОССОВЕР В КОМПЛЕКСАХ ЖЕЛЕЗА(II) С 2,6-БИС(1H-ИМИДАЗОЛ-2-ИЛ)ПИРИДИНАМИ
Authors: Лавренова Л.Г.
Published: December 2024

В обзоре представлены результаты цикла работ по синтезу и исследованию координационных соединений железа(II) с полиазотистыми гетероциклическими лигандами – производными 2,6-бис(1H-имидазол-2-ил)пиридина. Лиганды этого класса координируются к иону Fe(II) по тридентатно-циклическому типу двумя атомами азота имидазольных циклов и атомом азота пиридина с образованием катионных комплексов состава [ML2]2+ (координационный узел FeN6). Изучение зависимости магнитной восприимчивости от температуры показало, что в большинстве полученных комплексов проявляется спин-кроссовер 1А1 ↔ 5Т2. В ряде соединений изменение спиновой мультиплетности сопровождается термохромизмом. Обсуждены факторы, влияющие на температуру и характер спин-кроссовера.
Роль цифрових платформ та екосистем у формуванні сучасної бізнес-моделі аграрного підприємства
Authors: Yesyp Anatoliy , Bondarenko Serhiy
Published: December 2024

У статті досліджено вплив цифрових платформ та екосистем на формування сучасної бізнес-моделі аграрного підприємства. Проаналізовано показники цифрової трансформації аграрного сектору за 2010-2022 роки. Представлено види цифрових платформ, які застосовуються в бізнес-моделях аграрних підприємств, забезпечуючи ефективність, прозорість та інноваційність у всіх аспектах виробництва. Розглянуто сутність поняття «екосистема», дано визначення аграрній екосистемі. Надано характеристику видів екосистем в бізнес-моделі аграрного підприємства. Вивчено досвід успішного функціонування аграрних екосистем Нідерландів, Ізраїлю. Аналіз українського аграрного ринку свідчить про появу перших ознак формування екосистем підприємництва, заснованих на взаємодії великих агрохолдингів з іншими учасниками ринку. Проведено SWOT-аналіз розвитку цифрового агросектору України.
Стимулювання збуту в умо- вах конкурентного ринку: досвід провідних компаній
Authors: Chichulina Ksenia , Skryl Vitaliia
Published: December 2024

Стаття досліджує ефективні стратегії збуту для компанії ТОВ «Фірма ДІАМАНТ ЛТД» на основі АВС- та XYZ-аналізу. Зокрема, розглядаються методи сегментації продуктів за їхньою важливістю та стабільністю попиту. Стаття аналізує досвід провідних компаній щодо використання маркетингових інструментів, програм лояльності та інноваційних підходів для стимулювання продажів. Висвітлюється адаптація цих стратегій до умов локального ринку, враховуючи економічні та культурні особливості. Результати аналізу допомагають визначити ключові продукти для фокусування маркетингових зусиль, оптимізувати асортимент та підвищити ефективність збутової політики. Стаття є корисною для маркетологів, менеджерів з продажу та стратегічних планувальників, які прагнуть покращити конкурентоспроможність ТОВ «Фірма ДІАМАНТ ЛТД» на ринку органічної продукції.
Перспективи розвитку інклюзивного під- приємництва для демобілізованих військовослужбовців в Україні
Authors: Skrylnyk Andriy
Published: December 2024

У статті розглянуто перспективи розвитку інклюзивного підприємництва для демобілізованих військовослужбовців в Україні. Враховуючи виклики, пов'язані з реінтеграцією ветеранів у цивільне життя після військових конфліктів, підприємницька діяльність є ефективним механізмом соціально-економічної адаптації. Автор аналізує основні проблеми, які виникають у військових після демобілізації, і можливості розвитку бізнесу для цієї категорії громадян. У статті запропоновано стратегічні напрями підтримки інклюзивного підприємництва та розглянуто роль держави й суспільства у формуванні сприятливих умов для ветеранів. Висвітлюється важливість комплексного підходу до підтримки ветеранів у їхньому прагненні започаткувати та розвивати власний бізнес, що, у свою чергу, сприятиме соціально-економічному розвитку країни.
TREE-BASED STATE SHARDING FOR SCALABILITY AND LOAD BALANCING IN MULTICHAIN SYSTEMS
Authors: Kotov Maksym
Published: December 2024

Staying abreast with the fast-paced demand surge towards distributed consensus systems has become one of the global trends in the fields of science and engineering. The blockchain technology, its consensus protocols, communication methods, and architectural approaches are prevalent in trustless transactional systems. In that context, one of the key obstacles faced by engineers and interaction peers is the limited scalability capacity entailed with these systems due to consistency and reliability requirements. Modern blockchain systems introduce complexities related to the storage space management, transaction execution latencies, and, in general, the throughput of operations, which stifles the widespread integration of decentralized systems in day-to-day activities. In order to circumvent these limitations, a plethora of inter-chain communication protocols, sharding strategies, and capacity extension methods are being actively developed by both scientific and engineering communities to mitigate initial logical limitations of the proposed consensus technology. Nonetheless, the developed solutions are associated with limitations of their own, often converging to a bottlenecked point in their load balancing approach or sacrificing significantly in finality and latency properties. The purpose of this article is to introduce and describe the tree-based sharding approach of multichain systems. Firstly, this paper describes a general architecture of the proposed network, establishing a foundation upon which the later discussion takes place. Secondly, a set of communication methods involving parents, siblings, and remote branches to exchange transaction data. Lastly, the proposed sharding architecture and its properties are compared with a set of existing strategies towards achieving scalability within the confines of the blockchain technology. Overall, this article presents a novel approach towards building reliable, scalable, and highly efficient multichain systems through a structured tree-like hierarchy of cooperating blockchain networks.
INTEGRATION OF IOT AND ARTIFICIAL INTELLIGENCE INTO INTELLIGENT TRANSPORTATION SYSTEMS
Authors: Dovzhenko Nadiia , Mazur Nataliia , Kostiuk Yuliia , Rzaieva Svitlana
Published: December 2024

The article provides a detailed analysis of the conceptual and practical features of integrating Intelligent Transportation Systems (ITS) into urban environments, with a focus on the use of Internet of Things (IoT), Artificial Intelligence (AI), and edge computing technologies. A conceptual model of ITS has been developed, enabling not only real-time collection and processing of sensor data but also dynamic decision-making based on big data analytics. The multi-level architecture of ITS is examined, employing modern optimization, prediction, and clustering algorithms to enhance traffic management adaptability, minimize congestion, and reduce CO₂ emissions. Examples of successful ITS implementations in leading global cities are presented, showcasing their positive impact on increasing traffic throughput, reducing accident rates, and improving environmental conditions. Particular attention is paid to cybersecurity issues, which are critical for the stable and reliable operation of ITS. Potential threats associated with unauthorized access to system resources are analyzed, and the implementation of advanced encryption mechanisms, multi-factor authentication, and blockchain technologies is proposed to ensure data integrity and confidentiality. The article also highlights the development of effective anomaly detection algorithms capable of promptly responding to non-standard situations, such as traffic accidents or sudden changes in traffic flows. This ensures system resilience and flexibility in dynamic urban environments. The prospects for further ITS development through deeper integration of edge computing, Big Data technologies, and AI are emphasized, contributing to enhanced overall efficiency, safety, and adaptability of urban transportation infrastructure. The proposed ITS model incorporates energy efficiency, enables highly accurate traffic flow prediction, and ensures environmental sustainability in urbanized spaces. Practical recommendations for implementing the developed ITS are provided, emphasizing its ability to evolve and adapt to changes in traffic intensity, infrastructural constraints, and environmental safety requirements.
Soğuk Pres Keten ve Kenevir Tohumu Yağlarının Kalite Kriterlerinin, Oksidatif Stabilitelerinin ve Yağ Asidi Kompozisyonlarının Belirlenmesi
Authors: Çevik Kutlu , Alaşalvar Hamza , Yalçın Hasan
Published: December 2024

Bu çalışmada, piyasada ticari olarak satılan 4 farklı markaya ait soğuk pres keten ve kenevir tohumu yağlarının kalite kriterlerinin belirlenmesi amaçlanmıştır. Yağ örneklerinin serbest yağ asidi oranı kodeks limit değerlerinde olduğu belirlenirken, aynı markaya ait keten ve kenevir yağı örneklerinin peroksit sayısı değerlerinin kodeks limitlerini aştığı ve uymadığı tespit edilmiştir. Bu yağ örneklerinin diğer oksidasyon değerlerinin de yüksek olduğu belirlenmiştir. Keten ve kenevir tohumu yağlarında baskın olarak linoleik ve α-linolenik (ALA) yağ asitleri tespit edilmiştir. Bir markaya ait keten tohumu yağının ALA içeriğinin literatür verilerine kıyasla düşük olduğu ve içerisinde farklı bir karışım yağ olduğu sonucuna ulaşılmıştır. Ayrıca, her iki yağ örneğinde de γ-linolenik asit olduğu da tespit edilmiştir.
Monitoring of subclinical endomeritis in cows
Authors: Semivolos Alexander Mefodievich , Skvortsova Glafira Dmitrievna , Semivolos Sergey Aleksandrovich , Kalyuzhny Ivan Isaevich , Nechaeva Ksenia Yurievna
Published: December 2024

The article presents the results of research on the spread of various forms of endometritis in cows. Subclinical endometritis was most often recorded in cows of various farms. This form of endometritis was found in 35.0% of cows in JSC "PZ Meliorator", 33.93% in UNPO "Mummovskoye" and 26.35% in LLC "Stepnoye" of the Saratov region. Endometritis was noticeably more common in red-mottled cows. Clinical and laboratory studies have shown a clearly pronounced seasonal pattern of subclinical endometritis in cows. If in January – February this form of endometritis was registered in 15.91 – 24.56% of females, then in March - May it was 1.21-2.00 times more often. At a later date (September-December), a significant decrease in the number of cases of endometritis was observed - from 9.09 to 12.28%. Regardless of the breed, endometritis most often occurred at the age of 3-4 years (34.09 – 42.11%). At an older age (5-6 years), there is a decrease in cases of endometritis by 10.71; 7.02 and 9.09%, respectively. As the age of the animals increases further, there is an increase in the number of cases of subclinical endometritis in cows of all breeds.
Productivity and quality of the new potato variety Smolyanochka when using growth-stimulating drugs
Authors: Gavrilova Anna Yurievna , Konova Aminat Msostovna , Chekhalkova Larisa Konstantinovna , Kozunov Dmitry Viktorovich
Published: December 2024

The research was carried out in 2020 – 2022 in order to study the effect of drugs MedAgro and Epin on the yield and quality of potato tubers of the new Smolyanochka variety in the Smolensk region in the fields of a separate subdivision of the Smolensk Research Institute of the Federal Research Center for Bast Fiber Crops. The soil of the experimental site is sod-podzolic, medium loamy, slightly acidic, with a low humus content, an increased content of mobile forms of phosphorus and medium potassium. The object of the study was a medium-early variety of potato Smolyanochka, bred by Smolensk breeders. The effect of growth-stimulating drugs was studied on an optimal mineral background (azofoska 16:16:16 at a dose of 600 kg/ha). The use of growth-stimulating drugs, both separately according to the years of research, and on average over three years, offset the negative impact of adverse weather conditions and contributed to a more complete use of nutrients from fertilizers. The combined use of MedAgro with Epin increased the yield of tubers to 22.5 t/ha, while the greatest effect was noted in the variant with a concentration of 0.8% copper-containing preparation. In the same variant, due to an increase in the proportion of medium and large fractions of potato tubers, the highest marketability was obtained (86%). The use of growth-stimulating drugs, both jointly and unilaterally, practically did not change the starch concentration in tubers, but increased the dry matter content in them to 20.4%.
Substantiation of modern system of providing temperature regimes to reduce stress of animals
Authors: Komkov Ilya Vladimirovich , Dovlatov Igor Mamedyarovich , Yurochka Sergey Sergeevich , Blagov Dmitry Andreevich , Khakimov Artem Rustamovich
Published: December 2024

Nowadays, more and more attention is paid to the conditions of cattle housing in livestock breeding. Maintaining regulated values of microclimate parameters allows to fully realize genetic potential of animals. In this connection, it is necessary to provide regulation of microclimate parameters. Most of the parameters can be regulated by means of air exchange: natural, forced and combined ventilation. The most difficult to control microclimate parameter is temperature. Elevated air temperature has a detrimental effect on animal performance, health, fertility level and economic life. Prolonged exposure to high temperature values forces animals to adapt, which subsequently leads to endocrine system disruption. Various methods are used to reduce the effects of temperature stress, ranging from the use of additional ventilation equipment to the possible development of new heat-resistant/thermotolerant breeds. In materials and methods, the characteristics of such equipment are given. Compass-3D computer-aided design program (CAD), SolidWorks 2020 software package were used. Functional flowchart of the system and its operation modes are given in the results. The values of air velocity in summer and winter modes of operation have been determined: in the system 17,00–20,00 m/s, in the outlets 3,00–4,60 m/s, near animals 0,70–2,90 m/s and in the system 11,00–12,00 m/s, near animals 0,18–0,76 m/s respectively.
The improvement of the technology of protecting sugar beet from weeds in the south of the Non-Chernozem region
Authors: Bochkarev Dmitry Vladimirovich , Tyukina Ekaterina Vladimirovna , Slugin Andrey Nikolaevich , Drozdova Ksenia Olegovna , Dubrovin Vladimir Viktorovich , Devyatkina Tatyana Fedorovna
Published: December 2024

The results of studies assessing the effectiveness of the integrated use of herbicides and growth regulators in the cultivation of sugar beets are presented. It was found that the most effective system was the fractional application of herbicides: the first treatment used Betaren Super MD, MKE at a rate of 1.30 l/ha, Lornet, BP at a rate of 0.075 l/ha, Forvad, MKE at a dose of 0.80 l/ha ha, Condor, VDG at a dose of 0.03 l/ha, the second treatment – Betaren Super MD, MKE at a dose of 1.30 l/ha, Lornet, VR at a dose of 0.20 l/ha, Forvad, MKE at a rate of 1.00 l/ha, Condor, VDG at a dose of 0.045 l/ha and the third treatment – Betaren 22, MKE at a dose of 2.00 l/ha, Lornet, VR at a dose of 0.30 l/ha, Forvad, MKE at a rate of 1.00 l/ha, Condor, VDG at a dose of 0.045 l/ha. The biological effect in regulating the number of young weeds ranged from 46 to 94 %, and of perennial weeds from 67 to 91 % according to the survey periods. The greatest effect in reducing the weight of weeds by 98 % was observed with three times the use of herbicides in combination with Epin Extra. An assessment of the economic effectiveness of herbicides revealed that they had some herbitoxic effect, the harvest deficiency from which, when compared with mechanical weed removal, was about 6 t/ha. The use of Epin Extra did not weaken the effect of herbicides, but, on the contrary, enhanced the phytocenotic potential of the crop and in this variant the herbitoxic effect was smoothed out. The highest yield of 65.5 t/ha was ensured by three-fold application of the herbicide complex together with a growth regulator.
Polymorphism of the CAST gene in sheep of different breeds of the North Caucasus
Authors: Gadzhiev Zakir Kamilovich , Surzhikovа Evgeniya Semenovna , Shumaenko Svetlana Nikolaevna
Published: December 2024

Advances in animal genetics and breeding technologies have led to the widespread use of molecular markers to improve and select economically valuable traits in sheep farming. This article presents the material on DNA testing by PCR- RFLP of sheep of different breeds (Stavropol, Manych merino, North Caucasian meat and wool, Dagestan mountain, Russian meat merino, Kalmyk kurdyuchnaya, Kalmyk kurdyuchnaya (crossbreeds with a bloodline of ? Kalmyk kurdyuchnaya + ? Charolais), Dzhalginsky and Chernozemelsky merino), bred in conditions of various farms in the North Caucasus. In all the studied breeds, the frequency of the СASTМ allele significantly exceeded the frequency of the CASTN allele and was in the range from 0.78 to 0.90, therefore, the frequency of the CASTN allele was in the range from 0.22 to 0.10. The homozygous СASTММ genotype prevails in the genetic structure of sheep of different breeds according to the СAST gene. The heterozygous СASTMN genotype in the studied sheep samples ranged from 14.0 to 36.0 %, whereas the frequency of occurrence of the desired homozygous СASTNN genotype in all studied breeds was low and ranged from complete absence (0.0 %) to 7.0 %.
Breeding resources of beef breeds of cattle in the zone of the Volga Federal District
Authors: Lushnikov Vladimir Petrovich , Strilchuk Andrey Aleksandrovich , Kirilina Tatyana Olegovna , Tkacheva Galina Mikhailovna
Published: December 2024

The solution of the problem of high-quality beef production is directly related to the development of domestic beef cattle breeding. To realize the set goal it is necessary to emphasize the improvement of breeding base of beef cattle and the growth of competitive beef production. On the basis of the results of boning, the number of beef cattle and the main indicators of productivity for the period 2017-2023 in the regions of the Volga Federal District was analyzed. In the region there are 4 breeding plants and 28 breeding reproducers on breeding of cattle of Aberdeen Angus, Hereford, Kazakh white-headed, Kalmyk, Limousin breeds. The number of breeding animals of Hereford breed is increasing. For the last year the number of breeding stock in the Samara region increased almost six times, in the Saratov region more than twice, while in the Perm region the increase amounted to 42.6 %. Practice has shown that domestic breeds are competitive, so it is necessary to expand the scope of their further use.
Improving the accuracy of reproduction of a given shape of piston rings by taking into account the kinematic features of the copying unit of the HCFX-2 machine
Authors: Nikitin Dmitry Anatolievich , Nikitin Pavel Dmitrievich , Chekmarev Vasily Vasilievich , Rudik Felix Yakovlevich , Nikitina Ludmila Vladimirovna
Published: December 2024

Currently, the Russian Federation has a situation of dependence of the piston engine industry on foreign manufacturers and technologies. The closure of a number of enterprises that produced piston rings, as well as the dependence of imported blanks and copiers, led to interruptions in the production of internal combustion engines of various designation. To date, all competencies for both the manufacture of piston rings and the manufacture of means of production for their release in our country are considered lost by the authors, and their early restoration is an urgent task that requires prompt solutions. As a result, a problematic situation has developed in the Russian Federation, consisting in a contradiction between the need of domestic engineering for high-quality piston rings, on the one part, and the lack of a domestic manufacturer independent of imports, on the other part. It is noted that currently machines for the production of piston rings are not available in the Russian Federation. In this regard, PPK LLC had to purchase HCFX-2 turning and milling machines manufactured by Yuhuan CNC Machine Tool Co., LTD (China) for forming piston rings. But, as studies of the kinematics of the machine components providing copier processing have shown, there are a number of inaccuracies in the kinematic chain, leading to a certain error in the resulting surface profile of the piston rings. The authors have refined the methodology for calculating the profile of reference copiers. As a result, the authors built and implemented in the form of a program in C++ an algorithm for calculating the profile of a copier (cam) for the HCFX-2 turning and milling machine. The analysis of the calculation results confirmed their absolute reliability. The authors believe that this algorithm can be recommended for widespread use.