bluuebunny/crossref_metadata_2025 huggingface dataset:
MytiLec-1 Shows Glycan-Dependent Toxicity against Brine Shrimp Artemia and Induces Apoptotic Death of Ehrlich Ascites Carcinoma Cells In Vivo
Authors: Hasan Imtiaj , Asaduzzaman A.K.M. , Swarna Rubaiya Rafique , Fujii Yuki , Ozeki Yasuhiro , Uddin Md. Belal , Kabir Syed Rashel
Published: August 2019

MytiLec-1, a 17 kDa lectin with β-trefoil folding that was isolated from the Mediterranean mussel (Mytilus galloprovincialis) bound to the disaccharide melibiose, Galα(1,6) Glc, and the trisaccharide globotriose, Galα(1,4) Galβ(1,4) Glc. Toxicity of the lectin was found to be low with an LC50 value of 384.53 μg/mL, determined using the Artemia nauplii lethality assay. A fluorescence assay was carried out to evaluate the glycan-dependent binding of MytiLec-1 to Artemia nauplii. The lectin strongly agglutinated Ehrlich ascites carcinoma (EAC) cells cultured in vivo in Swiss albino mice. When injected intraperitoneally to the mice at doses of 1.0 mg/kg/day and 2.0 mg/kg/day for five consecutive days, MytiLec-1 inhibited 27.62% and 48.57% of cancer cell growth, respectively. Antiproliferative activity of the lectin against U937 and HeLa cells was studied by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay in vitro in RPMI-1640 medium. MytiLec-1 internalized into U937 cells and 50 μg/mL of the lectin inhibited their growth of to 62.70% whereas 53.59% cell growth inhibition was observed against EAC cells when incubated for 24 h. Cell morphological study and expression of apoptosis-related genes (p53, Bax, Bcl-X, and NF-κB) showed that the lectin possibly triggered apoptosis in these cells.
Vitamin D Deficiency: Consequence or Cause of Obesity?
Authors: Vranić Luka , Mikolašević Ivana , Milić Sandra
Published: August 2019

Obesity is defined as an excess amount of body fat and represents a significant health problem worldwide. High prevalence of vitamin D (VD) deficiency in obese subjects is a well-documented finding, most probably due to volumetric dilution into the greater volumes of fat, serum, liver, and muscle, even though other mechanisms could not completely be excluded, as they may contribute concurrently. Low VD could not yet be excluded as a cause of obesity, due to its still incompletely explored effects through VD receptors found in adipose tissue (AT). VD deficiency in obese people does not seem to have consequences for bone tissue, but may affect other organs, even though studies have shown inconsistent results and VD supplementation has not yet been clearly shown to benefit the dysmetabolic state. Hence, more studies are needed to determine the actual role of VD deficiency in development of those disorders. Thus, targeting lifestyle through healthy diet and exercise should be the first treatment option that will affect both obesity-related dysmetabolic state and vitamin D deficiency, killing two birds with one stone. However, VD supplementation remains a treatment option in individuals with residual VD deficiency after weight loss.
High Temperature Corrosion and Oxidation of Metals
Authors: Singh Raman , Venkataraman Mahesh B.
Published: August 2019

Corrosion costs heavily, and its prevention is a multi-billion-dollar industry [...]
Pathobiology of Aspergillus Fumigatus Endophthalmitis in Immunocompetent and Immunocompromised Mice
Authors: Gupta Neha , Singh Pawan Kumar , Revankar Sanjay G. , Chandrasekar Pranatharthi H. , Kumar Ashok
Published: August 2019

Despite Aspergillus being the leading cause of exogenous fungal endophthalmitis following traumatic injury to the eye, its pathogenesis is not fully understood. In the current study, we developed a murine model of Aspergillus fumigatus (AF) endophthalmitis and investigated the disease pathobiology. Endophthalmitis was induced by intravitreal injection of Aspergillus spores in immunocompetent and immunocompromised (neutropenic) C57BL/6 mice, and disease severity was assessed by eye exam, fungal burden estimation, and histological examination. Our data showed that AF infection caused a time-dependent increase in corneal haze, opacity, and hypopyon beginning at two days post-infection (DPI). The fungal burden in infected eyes of immunocompetent mice peaked at 2 DPI and declined over 9 DPI. AF-infected neuroretina exhibited induction of innate immune response via upregulation of Toll-like receptors (TLRs) and inflammatory mediators (TNFα, IL-1β, and IL6), and increased polymorphonuclear neutrophil (PMN) infiltration. Histological analysis revealed heavy cellular infiltrates in the vitreous cavity as well as disruption of normal retinal architecture and increased retinal cell death. Neutropenic mice exhibited severe disease pathology with the prolonged fungal burden and increased inflammatory mediators. Our study described the first immunocompetent murine model of exogenous AF endophthalmitis and demonstrated an important role of neutrophils in innate defense against fungal endophthalmitis.
The Preparation and Structure Analysis Methods of Natural Polysaccharides of Plants and Fungi: A Review of Recent Development
Authors: Ren Yan , Bai Yueping , Zhang Zhidan , Cai Wenlong , Del Rio Flores Antonio
Published: August 2019

Polysaccharides are ubiquitous biomolecules found in nature that contain various biological and pharmacological activities that are employed in functional foods and therapeutic agents. Natural polysaccharides are obtained mainly by extraction and purification, which may serve as reliable procedures to enhance the quality and the yield of polysaccharide products. Moreover, structural analysis of polysaccharides proves to be promising and crucial for elucidating structure–activity relationships. Therefore, this report summarizes the recent developments and applications in extraction, separation, purification, and structural analysis of polysaccharides of plants and fungi.
Assessment of the Impact of Accelerated Migration Testing for Coated Food Cans Using Food Simulants
Authors: Paseiro-Cerrato Rafael , DeJager Lowri , Begley Timothy H.
Published: August 2019

In this study, an accelerated migration test on food can coatings into food simulants was investigated. Food simulants covering a wide range of polarity were used to conduct migration tests at 60 °C with storage times ranging from 4 h to 30 days. Epoxy-resins, acrylic–phenolic, polyester, and vinyl coatings were exposed to water, 3% acetic acid, 50% ethanol, and Miglyol 812®. Using liquid chromatography coupled to a variety of detectors (UHPLC-Q-Orbitrap-MS, UFLC-MS/MS, and HPLC-DAD), migration of several monomers and previously identified oligomers, as well as some unidentified migrants, were determined during the experiment. The data from this study was compared to our findings from previous long-term migration studies with storage times ranging from 24 h to 540 days at 40 °C using the same can coating applications. The results illustrate that performing migration experiments for short time periods at 60 °C may mimic migration results that would be obtained at 40 °C after long-term migration tests (up to 1.5 years) from food can coatings into food simulants.
Tracing Potential Covalent Inhibitors of an E3 Ubiquitin Ligase through Target-Focused Modelling
Authors: Bjij Imane , Ramharack Pritika , Khan Shama , Cherqaoui Driss , Soliman Mahmoud E. S.
Published: August 2019

The Nedd4-1 E3 Ubiquitin ligase has been implicated in multiple disease conditions due its overexpression. Although the enzyme may be targeted both covalently and non-covalently, minimal studies provide effective inhibitors against it. Recently, research has focused on covalent inhibitors based on their characteristic, highly-selective warheads and ability to prevent drug resistance. This prompted us to screen for new covalent inhibitors of Nedd4-1 using a combination of computational approaches. However, this task proved challenging due to the limited number of electrophilic moieties available in virtual libraries. Therefore, we opted to divide an existing covalent Nedd4-1 inhibitor into two parts: a non-covalent binding group and a pre-selected α, β-unsaturated ester that forms the covalent linkage with the protein. A non-covalent pharmacophore model was built based on molecular interactions at the binding site. The pharmacophore was then subjected to virtual screening to identify structurally similar hit compounds. Multiple filtrations were implemented prior to selecting four hits, which were validated with a covalent conjugation and later assessed by molecular dynamic simulations. The results showed that, of the four hit molecules, Zinc00937975 exhibited advantageous molecular groups, allowing for favourable interactions with one of the characteristic cysteine residues. Predictive pharmacokinetic analysis further justified the compound as a potential lead molecule, prompting its recommendation for confirmatory biological evaluation. Our inhouse, refined, pharmacophore model approach serves as a robust method that will encourage screening for novel covalent inhibitors in drug discovery.
Design, Synthesis, and Anticancer Effect Studies of Iridium(III) Polypyridyl Complexes against SGC-7901 Cells
Authors: Zhang Li-Xia , Gu Yi-Ying , Wang Yang-Jie , Bai Lan , Du Fan , Zhang Wen-Yao , He Miao , Liu Yun-Jun , Chen Yan-Zhong
Published: August 2019

Three iridium(III) complexes ([Ir(Hppy)2(L)](PF6) (Hppy = 2-phenylpyridine, L = 5-nitrophenanthroline, NP), 1; 5-nitro-6-amino-phenanthroline (NAP), 2; and 5,6-diamino-phenanthroline (DAP) 3 were synthesized and characterized. The cytotoxicities of Ir(III) complexes 1–3 against cancer cell lines SGC-7901, A549, HeLa, Eca-109, HepG2, BEL-7402, and normal NIH 3T3 cells were investigated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazoliumbromide (MTT) method. The results showed that the three iridium(III) complexes had moderate in vitro anti-tumor activity toward SGC-7901 cells with IC50 values of 3.6 ± 0.1 µM for 1, 14.1 ± 0.5 µM for 2, and 11.1 ± 1.3 µM for 3. Further studies showed that 1–3 induce cell apoptosis/death through DNA damage, cell cycle arrest at the S or G0/G1 phase, ROS elevation, increased levels of Ca2+, high mitochondrial membrane depolarization, and cellular ATP depletion. Transwell and Colony-Forming assays revealed that complexes 1–3 can also effectively inhibit the metastasis and proliferation of tumor cells. These results demonstrate that 1–3 induce apoptosis in SGC-7901 cells through ROS-mediated mitochondrial damage and DNA damage pathways, as well as by inhibiting cell invasion, thereby exerting anti-tumor cell proliferation activity in vitro.
A Self-Supported CuO/Cu Nanowire Electrode as Highly Efficient Sensor for COD Measurement
Authors: Huang Xinwen , Zhu Yingying , Yang Wanquan , Jiang Anhua , Jin Xiaoqiang , Zhang Yirong , Yan Liang , Zhang Geshan , Liu Zongjian
Published: August 2019

A self-supported CuO/Cu nanowire electrode (CuO/CuNWE), which was prepared by annealing Cu nanowires to form a porous Cu nanowire electrode (CuNWE) and then anodizing the as-prepared CuNWE in alkaline medium to generate Cu(OH)2 nanowires followed by calcination, was employed for chemical oxygen demand (COD) determination using cyclic voltammetry (CV). The structure and electrochemical behavior of the CuO/CuNWE were investigated by scanning electron microscopy, X-ray diffraction, and CV. The results indicated that the as-synthesized CuO/CuNWE, in which CuO nanowires with a length of several micrometers and a diameter of 100 to 300 nm could be found, was stable in alkaline medium and more electrocatalytically active for oxidizing a wide range of organic compounds in comparison with the CuNWE. Under optimized alkaline concentration and scan rate, the CuO/CuNWE exhibited a good performance for COD measurement, with a linear range of 5 to 1153 mg L−1, a sensitivity of 2.46× 10−2 mA /(mg L−1), and a detection limit of about 2.3 mg L−1. In addition, an excellent correlation was observed in COD values obtained by our method and the classic dichromate method (r = 0.9995, p < 0.01, n = 11). Finally, our method was successfully used to measure the COD values in real water samples, showing great potential for practical application in water pollution control.
Improved Laser Damage Threshold of In2Se3 Saturable Absorber by PVD for High-Power Mode-Locked Er-Doped Fiber Laser
Authors: Han Xile , Zhang Huanian , Jiang Shouzhen , Zhang Chao , Li Dengwang , Guo Quanxin , Gao Jinjuan , Man Baoyuan
Published: August 2019

In this study, a double-end pumped high-power passively mode-locked erbium-doped fiber laser (EDFL) was realized by employing a few-layered In2Se3 flakes as a saturable absorber (SA). Herein, the uniform large-scale In2Se3 flakes were synthesized by the physical vapor deposition (PVD) method. The PVD-In2Se3 SA exhibited a remarkable damage threshold of higher than 24 mJ/cm2. Meanwhile, the PVD-In2Se3 SA had a modulation depth and saturable intensity of 18.75% and 6.8 MW/cm2, respectively. Based on the In2Se3 SA, the stable bright pulses emitting at 1559.4 nm with an average output power/pulse energy/pulse duration of 122.4 mW/5.8 nJ/14.4 ns were obtained successfully. To our knowledge, 122.4 mW was the new major breakthrough of mode-locked Er-doped fiber lasers. In addition, this is the first demonstration of the dark-bright pulse pair generation based on In2Se3 SA. The maximum average output power of the dark-bright pulse reached 121.2 mW, which also showed significant enhancement in comparison with previous works. Our excellent experiment results fully prove the superiority of our experimental design scheme and indicate that the PVD-In2Se3 could operate as a promising highly-nonlinear photonic material for a high-power fiber laser.
Gene Expression Maps in Plants: Current State and Prospects
Authors: Klepikova Anna V. , Penin Aleksey A.
Published: August 2019

For many years, progress in the identification of gene functions has been based on classical genetic approaches. However, considerable recent omics developments have brought to the fore indirect but high-resolution methods of gene function identification such as transcriptomics, proteomics, and metabolomics. A transcriptome map is a powerful source of functional information and the result of the genome-wide expression analysis of a broad sampling of tissues and/or organs from different developmental stages and/or environmental conditions. In plant science, the application of transcriptome maps extends from the inference of gene regulatory networks to evolutionary studies. However, only some of these data have been integrated into databases, thus enabling analyses to be conducted without raw data; without this integration, extensive data preprocessing is required, which limits data usability. In this review, we summarize the state of plant transcriptome maps, analyze the problems associated with the combined analysis of large-scale data from various studies, and outline possible solutions to these problems.
A Low-Temperature Micro Hotplate Gas Sensor Based on AlN Ceramic for Effective Detection of Low Concentration NO2
Authors: Zhao Wen-Jie , Xu Dan , Chen Yin-Sheng , Wang Xuan , Shi Yun-Bo
Published: August 2019

Air pollution is one of the major threats to human health. The monitoring of toxic NO2 gas in urban air emission pollution is becoming increasingly important. Thus, the development of an NO2 sensor with low power consumption, low cost, and high performance is urgent. In this paper, a planar structural micro hotplate gas sensor based on an AlN ceramic substrate with an annular Pt film heater was designed and prepared by micro-electro-mechanical system (MEMS) technology, in which Pt/Nb/In2O3 composite semiconductor oxide was used as the sensitive material with a molar ratio of In:Nb = 9:1. The annular thermal isolation groove was designed around the heater to reduce the power consumption and improve the thermal response rate. Furthermore, the finite element simulation analysis of the thermal isolation structure of the sensor was carried out by using ANSYS software. The results show that a low temperature of 94 °C, low power consumption of 150 mW, and low concentration detection of 1 to 10 ppm NO2 were simultaneously realized for the Nb-doped In2O3-based gas sensor. Our findings provide a promising strategy for the application of In2O3-based sensors in highly effective and low concentration NO2 detection.
ARTS, an AR Tourism System, for the Integration of 3D Scanning and Smartphone AR in Cultural Heritage Tourism and Pedagogy
Authors: Shih Naai-Jung , Diao Pei-Huang , Chen Yi
Published: August 2019

Interactions between cultural heritage, tourism, and pedagogy deserve investigation in an as-built environment under a macro- or micro-perspective of urban fabric. The heritage site of Shih Yih Hall, Lukang, was explored. An Augmented Reality Tourism System (ARTS) was developed on a smartphone-based platform for a novel application scenario using 3D scans converted from a point cloud to a portable interaction size. ARTS comprises a real-time environment viewing module, a space-switching module, and an Augmented Reality (AR) guide graphic module. The system facilitates scenario initiations, projection and superimposition, annotation, and interface customization, with software tools developed using ARKit® on the iPhone XS Max®. The three-way interaction between urban fabric, cultural heritage tourism, and pedagogy was made possible through background block-outs and an additive or selective display. The illustration of the full-scale experience of the smartphone app was made feasible for co-relating the cultural dependence of urban fabric on tourism. The great fidelity of 3D scans and AR scenes act as a pedagogical aid for students or tourists. A Post-Study System Usability Questionnaire (PSSUQ) evaluation verified the usefulness of ARTS.
Marine Observation Beacon Clustering and Recycling Technology Based on Wireless Sensor Networks
Authors: Zhang Zhenguo , Qi Shengbo , Li Shouzhe
Published: August 2019

Monitoring of marine polluted areas is an emergency task, where efficiency and low-power consumption are challenging for the recovery of marine monitoring equipment. Wireless sensor networks (WSNs) offer the potential for low-energy recovery of marine observation beacons. Reducing and balancing network energy consumption are major problems for this solution. This paper presents an energy-saving clustering algorithm for wireless sensor networks based on k-means algorithm and fuzzy logic system (KFNS). The algorithm is divided into three phases according to the different demands of each recovery phase. In the monitoring phase, a distributed method is used to select boundary nodes to reduce network energy consumption. The cluster routing phase solves the extreme imbalance of energy of nodes for clustering. In the recovery phase, the inter-node weights are obtained based on the fuzzy membership function. The Dijkstra algorithm is used to obtain the minimum weight path from the node to the base station, and the optimal recovery order of the nodes is obtained by using depth-first search (DFS). We compare the proposed algorithm with existing representative methods. Experimental results show that the algorithm has a longer life cycle and a more efficient recovery strategy.
Cancer diagnoses after emergency GP referral or A&E attendance in England: determinants and time trends in Routes to Diagnosis data, 2006–2015
Authors: Herbert Annie , Abel Gary A , Winters Sam , McPhail Sean , Elliss-Brookes Lucy , Lyratzopoulos Georgios
Published: August 2019

Background

Diagnosis of cancer as an emergency is associated with poor outcomes but has a complex aetiology. Examining determinants and time trends in diagnostic routes can help to appreciate the critical role of general practice over time in diagnostic pathways for patients with cancer.

Aim

To examine sociodemographic, cancer site, and temporal associations with type of presentation among patients with cancer diagnosed as emergencies.

Design and setting

Analysis of Routes to Diagnosis data, 2006–2015, for patients with cancer in England.

Method

The authors estimated adjusted proportions of emergency presentation after emergency GP referral (GP-EP) or presentation to accident and emergency (AE-EP), by patient sex, age, deprivation group, and year of diagnosis using multivariable regression.

Results

Among 554 621 patients presenting as emergencies, 24% (n = 130 372) presented as GP-EP, 62% as AE-EP (n = 346 192), and 14% (n = 78 057) through Other-EP sub-routes. Patients presenting as emergencies were more likely to have been GP-referred if they lived in less deprived areas or were subsequently diagnosed with pancreatic, gallbladder, or ovarian cancer, or acute leukaemia. During the study period the proportion and number of GP-EPs nearly halved (31%, n = 17 364, in 2006; 17%, n = 9155 in 2015), while that of AE-EP increased (55%, n = 31 049 to 68%, n = 36 868).

Conclusion

Patients presenting as emergencies with cancers characterised by symptoms/signs tolerable by patients but appropriately alarming to doctors (for example, pancreatic cancer manifesting as painless jaundice) are over-represented among cases whose emergency presentation involved GP referral. Reductions in diagnoses of cancer through an emergency presentation likely reflect both the continually increasing use of 2-week-wait GP referrals during the study period and reductions in emergency GP referrals.
Route to heart failure diagnosis in English primary care: a retrospective cohort study of variation
Authors: Kim Dani , Hayhoe Benedict , Aylin Paul , Majeed Azeem , Cowie Martin R , Bottle Alex
Published: August 2019

Background

Despite the existence of evidence-based guidelines supporting the identification of heart failure (HF) in primary care, the proportion of patients diagnosed in this setting remains low. Understanding variation in patients’ routes to diagnosis will better inform HF management.

Aim

To identify the factors associated with variation in patients’ routes to HF diagnosis in primary care.

Design and setting

A retrospective cohort study of 13 897 patients diagnosed with HF between 1 January 2010 and 31 March 2013 in English primary care.

Method

This study used primary care electronic health records to identify routes to HF diagnosis, defined using the National Institute for Health and Care Excellence (NICE) guidelines, and adherence to the NICE-recommended guidelines. Multilevel logistic regression was used to investigate factors associated with the recommended route to HF diagnosis, and funnel plots were used to visualise variation between practices.

Results

Few patients (7%, n = 976) followed the recommended route to HF diagnosis. Adherence to guidelines was significantly associated with younger age (P = 0.001), lower deprivation level (P = 0.007), HF diagnosis source (P<0.001), not having chronic pulmonary disease (P<0.001), receiving further consultation for symptom(s) suggestive of HF (P<0.001), and presenting with breathlessness (P<0.001). Route to diagnosis also varied significantly between GP practices (P<0.001).

Conclusion

The significant association of certain patient characteristics with route to HF diagnosis and the variation between GP practices raises concerns about equitable HF management. Further studies should investigate reasons for this variation to improve the diagnosis of HF in primary care. However, these must consider the complexities of a patient group often affected by frailty and multiple comorbidities.
PROFICIENCY OF SUGARCANE CLONES/ VARIEITIES AT DIFFERENT LOCATIONS IN THAL AND SOUTHERN PUNJAB
Authors: Sarwar Muhammad
Published: August 2019

The performance of promising varieties was compared with already released. The varieties trail was conducted at four different sites in Punjab, it is an essential component of sugarcane research and thus provides an important basis of recommendations to growers. The objective of this paper is to evaluate promising varieties under different ecological zones. Seven sugarcane promising and two commercial clones were evaluated. These clones were tested for their performance at four locations during Feb-March-2017 in “Thal” and South Punjab viz; Karampur Mailsi, Layyah, Alipur and Khanpur. The trials were conducted at farmer’s field using RCBD with three replications. The data on germination%, Tillers/Plant, number of mill able cane, cane yield t/ha and commercial cane sugar% (CCS) were recorded during the course of study. Overall, pooled mean of four locations indicate that cane yield of clone S2003-US-127 produced statistically higher significant 124.64 t/ha cane yield as compared HSF-240 that produced statistically lower yield i.e. 103.14 t/ha. The Brix% of overall mean of four locations results S2003-US-633 was statistically significant i.e. 24.47% and Brix% of overall mean of four locations results S2008-AUS-134 was statistically lower i.e. 19.38%.
Perancangan Prototype LKS Materi Operasi Hitung Bilangan Bulat Untuk Peserta Didik Sekolah Dasar
Authors: Iis Juniati Putri Cahyani Agustine, Fitri Apriani,
Published: August 2019

Matematika merupakan ilmu universal yang mendasari perkembangan teknologi modern, mempunyai peranan penting dalam berbagai disiplin ilmu dan memajukan daya pikir manusia. Matematika perlu diberikan kepada semua  peserta didik   mulai dari sekolah dasar untuk membekali peserta didik dengan kemampuan berpikir logis, analitis, sistematis, kritis, kreatif, dan kemampuan bekerja sama. Tahapan-tahapan aspek yang berurutan dalam matematika yaitu  bilangan, geometri dan pengukuran serta pengolahan data. Dari tahapan aspek yang disebutkan terlihat bahwasannya pokok bahasan bilangan merupakan tahapan awal yang harus dikuasai dalam matematika. Bilangan merupakan pokok bahasan dasar yang sangat penting dipahami oleh para peserta didik  karena merupakan landasan untuk pokok-pokok bahasan lainnya. Salah satu bagian dari pokok bahasan bilangan ini adalah bilangan bulat. Untuk itu, penelitian ini bertujuan untuk mengembangkan bahan ajar berupa LKS materi operasi hitung bilangan bulat untuk peserta didik  sekolah dasar. Penelitian ini merupakan tahap awal dari penelitian pengembangan. Subjek penelitian adalah peserta didik  kelas IV SD Negeri 42 Pangkalpinang. Penelitian ini dilakukan tahap preliminary (persiapan) dan tahap formative evaluation ( self evaluation) yang menghasilkan prototipe pertama LKS materi operasi hitung bilangan bulat untuk peserta didik  sekolah dasar.
Preliminary Feasibility of Using Natural Wetland for University Wastewater Treatment: A Case Study
Authors: Pasukphun Nittaya , Suma Yanasinee , Keawdunglek Vivat , Laor Pussadee , Hongtong Anuttara
Published: August 2019

Wetlands contribute to water quality improvement and play an important role in the global carbon cycle. As such, wetlands can sequester carbon and mitigate greenhouse gas emissions. This study utilized a survey as a preliminary investigation of the feasibility of using natural wetlands for university wastewater treatment. A total of 13 natural ponds containing water from rainfall and some discharge from the Rotating Batch Contractor (RBC) in Mae Fah Luang University (MFU) were selected. Of all the 13 ponds, the pond at the stadium was selected as the most suitable, due to the following physical and chemical parameters: slope was < 5%, maximum depth was 3.1 m, mean temperature of 24.5 °C, dissolved oxygen 6.31 mg L-1, pH 7.56, TDS 180 ppt, electrical conductivity 253 μS cm-1, and containing 2.35 % organic matter. Total cost and carbon emissions were compared between RBC and the proposed natural wetland. Construction, operation and maintenance costs of natural wetland were very low compared with RBC due to no chemical, electricity and skilled staff required. Similarly, the lower electrical consumption of the natural wetland resulted in reduced carbon emissions of 102.9 kg CO2eq per year. This preliminary result can be used to select possible options for university wastewater treatment.
Analysis of Air Quality Impacts on Human Health Using the Geoinformatics Application: Chiang Rai Province
Authors: Hongthong Anuttara , Suma Yanasinee , Pasukphun Nittaya , Keawdounglek Vivat
Published: August 2019

This research aims to study air pollution dispersion in Chiang Rai Province, Thailand. The relationship between air pollutants, meteorology and population health were considered. The levels of air pollutants were used to establish a spatial and temporal analysis by Inverse Distance Weighted (IDW) interpolation from Geographic Information Systems (GIS), involved with occurrences of disease cases in the study area. The average monthly air pollution data were collected from Thailand’s Pollution Control Department and data on respiratory disease were collected from Chiang Rai Provincial Public Health Office during 2011 to 2014. The results indicated that monthly average PM10 concentrations started to rise from December to April. PM10 concentrations peaked during the hot season of every year, when open burning is prac-ticed. During this period, PM10 levels exceeded Thailand’s national ambient air quality standardsof 120 μg m-3. Accumulative influenza and pneumonia cases in Chiang Rai Province were very high in Chiang Rai city centre. The spatial temperature distribution map showed higher incidence of cases of influenza and pneumonia throughout the lower temperature area of Chiang Rai city centre. Influenza was affected by PM10, rainfall, relative humidity, and temperature, according to the following correlation ratios: 0.8217, 0.8842, 0.9375 and 0.8775, respectively. The incidence of pneumonia was affected by rainfall, relative humidity and temperature following the correlation ratios 0.7746, 0.7621 and 0.9684, respectively. Whereas PM10 was low associated with pneumonia as a significant ratio was 0.6079. Pneumonia incidence decreased when rainfall and temperature decreased, and increased when relative humidity increased.
Faktor – Faktor Yang Berhubungan Dengan Kesiapan Ibu Dalam Menghadapi Sibling Rivalry Pada Anak Usia Todler
Authors: Anggraeni Lina , Sipayung Gina Sari
Published: August 2019

Kesiapan ibu dalam menghadapi Sibling Rivalry pada anak usia todler merupakan hal yang penting karena dapat meminimalkan dampak negatif yang mungkin terjadi dikemudian hari. Tujuan penelitian untuk mengetahui faktor-faktor yang berhubungan dengan kesiapan ibu dalam menghadapi sibling rivalry pada anak usia todler di RS X Bekasi. Metode  penelitian korelasi deskriptif analitik dengan desain penelitian Cross Sectional dengan besar sampel 96 ibu yang memiliki dan mengasuh anak usia todler. Hasil penelitian menunjukan 59,4% responden berada pada rentang usia dewasa awal, responden berpendidikan rendah sebesar 55,2%, responden berpengalaman dalam menghadapi Sibling Rivalry sebesar 65,6%, responden memiliki pengetahun yang baik 60,4%, responden memiliki sikap yang positif  60,4%, responden siap dalam menghadapi sibling rivalry 53,1%. Dalam analisis bivariat, ada hubungan yang bermakna antara pengetahuan dan sikap dengan kesiapan ibu dalam menghadapi sibling rivalry (p<0,05). Diharapkan penelitian ini dapat meningkatkan peran perawat dalam memberikan asuhan keperawatan mandiri sebagai promosi kesehatan mengenai Sibling Rivalry kepada keluarga.
A Geographical Overview of Language Family
Authors: Grgic Sanjin
Published: August 2019

Language is a mean of communication among people including speech, writing, and singing. Language is an important factor in geographical diversity. The English word language drives from the Indo-European. Language is the human ability to acquire and use complex systems of communication. The scientific study of language is called linguistic. Language is a strong element of culture. "Language is a systematic means of communicating ideas and feeling by the use of conventionalized sings, gestures, marks or especially articulate vocal sounds”. At present 5-6, thousands of languages are present in the world. Between them 1200, languages are present in Africa and 600 languages in India. Language provides the single most common variable by which cultural groups are identified. Language provides the main means by which learned customs and skills pass from one generation to the next. Facilitates cultural diffusion of innovations. Because languages vary spatially, they reinforce the sense of region and place. Study of language called linguistic geography and geolinguistics by geographers.
An Elaboration of the Administrative Theory of the 14 Principles of Management by Henri Fayol
Authors: Edwards Raymond
Published: August 2019

Fayolism was a theory of management that analyzed and synthesized the role of management in organizations, developed around 1900 by the French management theorist Henri Fayol (1841–1925). It was through Fayol's work as a philosopher of administration that he contributed most widely to the theory and practice of organizational management. Fayol developed theory of management. According to him managerial excellence is a technically ability and can be acquired. He developed theories and principles of management which are universally accepted and make him universalistic. He was pioneer of the formal education in management. Fayol’s principles of management meet the requirements of modern management.
Sonochemical Degradation of Phenol and Para-Chlorophenol in an Ultrasonic bath in the Presence of Inorganic Salts and H2O2
Authors: Uddin Md. Helal , Hossain Md. Jahangir , Islam Md. Shaharul
Published: August 2019

Phenol (Ph) and some of its derivatives such as para chloro-phenol (PCP) have received considerable attention from environmental scientists and engineers, due to their undesirable effects in the water environment, where they end up as a result of improper disposal methods. As a consequence, research has been conducted all around the world with the common goal of reducing their concentrations to allowable limits or converting them to non-toxic, non-hazardous forms that may easily be handled by natural decay processes. This report describes a system developed to degrade these substances using sonochemical reactions. Sonochemical degradation of phenolic compounds were carried out in the presence and absence of NaCl, Na2SO4, Na2CO3, NaNO3 and H2O2. In sonochemical degradation of phenol in sonicatior hight degradation rate was obtained in the presence of additives H2O2 and followed the order: Ph+H2O2 > Ph+Na2SO4 ? Ph+NaCl > Ph (0 mM salt & additive) ? Ph+NaNO3 > Ph+Na2CO3. Whereas, in case of parachlorophenol (PCP) hight rate was obtained in the presec of H2O2 and they followed the order: PCP+H2O2 > PCP+NaCl > PCP+Na2SO4 ? PCP (0 mM salt & additive) > PCP+Na2CO3 > PCP + NaNO3.
Adopting a Conflict Resolution Perspective towards Terrorism – Possibilities and Limitations
Authors: Subarna Kaniz
Published: August 2019

Living in the world in peace and with dignity is the utmost desire of each and every human being. Everyone wishes to live in a society where only peace and humanity reign. But in the present world, at every moment world peace is getting endangered by ‘terrorism’ - the most horrifying phenomenon of the contemporary world
Kant’s Categorical Imperative and Duty
Authors: Basara Karif Jal
Published: August 2019

The categorical imperative is the central philosophical concept in the deontological moral philosophy of Immanuel Kant. Introduced in Kant's 1785 Groundwork of the Metaphysics of Morals, it may be defined as a way of evaluating motivations for action.
Theory & Analysis of Contemporary Political Philosophy
Authors: Totah Mahbub Rafiq
Published: August 2019

Here we will discuss about many viewpoints of modern political philosophy. Many modern political philosophers of modern time will be discussed here. Here some philosophers are also economists, scholars and so on. Here the history of political philosophy will be discussed. The origin of this period and long silence of the history are described.
European Union & its Contribution to the Development of Society and Nation
Authors: Billah Masum
Published: August 2019

The European Union (EU) is a political and economic union of 28 member states that are located primarily in Europe. It has an area of 4,475,757 km2 (1,728,099 sq mi) and an estimated population of about 513 million. The EU has developed an internal single market through a standardized system of laws that apply in all member states in those matters, and only those matters, where members have agreed to act as one. EU policies aim to ensure the free movement of people, goods, services and capital within the internal market, enact legislation in justice and home affairs and maintain common policies on trade, agriculture, fisheries and regional development. For travel within the Schengen Area, passport controls have been abolished. A monetary union was established in 1999 and came into full force in 2002 and is composed of 19 EU member states which use the euro currency.
Contemporary Compendium of Conventions (CCC) in MANET
Authors:   Research Scholar department of E&TC ZCOER , Savitribai Phule Pune University , Pune, India., Chilveri Purushottam G Chilveri, , Nagmode Dr. M.S. ,   E&TC, Savitribai Phule Pune University, Pune, India.
Published: August 2019

Incessantly a self configuring network for mobile devices known as Mobile Ad hoc Network (MANET) are associated wirelessly .In significant networks, this design might perhaps enforce increased computational costs owing to the costly credentials chaining overheads that would not adapt for ad-hoc applications with increased nodes. Here a survey is carried out to express a view on the secure and authentic MANET systems. The literature reviewed is on different and diverse techniques of related to MANET systems. Reviews of 65 papers is presented and stated the significant analysis. At first the analysis depicts various attacks that are contributed in different papers. Subsequently ,various measures like security, cost, simulation time etc are also analyzed. It analyses the encryption method also that is exploited in each paper. This paper further gives an insight regarding the tools adapted ,chronological review and performance achievements in each case. At the end the review extended for the different research issues to investigate further research on secure and authentic MANET system.
Learning Towards Failure Prediction of High Performance Computing Clusters by Employing LSTM
Authors:   Department of Computer Engineering & Technology, Guru Nanak Dev University, Amritsar, Punjab, India., Kaur Kamaljit , Kaur Kuljit ,   Department of Computer Science, Guru Nanak Dev University, Amritsar, Punjab, India.
Published: August 2019

This Failure prediction of high-performance computing clusters (HPCC) is a crucial issue and a hot problem for many years. Previous works have failed to provide a robust method for real-time failure prediction of HPCC. The available techniques are old, unrealistic and provide low accuracy. This paper presents an efficient technique which provides robust failure prediction with good accuracy and state of the art models. We have employed the concept of long short-term memory (LSTM) with reinforcement learning to correct the prediction accuracy in real-time and provide a solution to the industry with reliable results.
Machining Performance Optimization For Minimizing Material Losses By Thickness Variation Method
Authors:   Department of Mechanical Engineering,, R.M.K. Engineering College, Chennai, India., C Jayabalan , M Logesh ,   Department of Mechanical Engineering, Vel Tech Multitech, Chennai, India., G Ramesh ,   Department of Mechanical Engineering, MEA Engg College, Perinthalmanna, Kerala, India., M Selvam ,   Department of Mechanical Engineering, Vel Tech Multitech, Chennai, India., S Palani ,   Department of Mechanical Engineering, Vel Tech Multitech, Chennai, India.
Published: August 2019

In this project a problem is identified and analyzed, modified and resulted. The problem identified in this project was thickness gets varied in mass production of brake linings which leads to various material losses during grinding operation. The thickness variation is mainly obtained during preforming and curing operation. In this project a problem is identified by various strategies of man, material and mould. Various analyses were taken on the strategies and concluded with a problem. The solution to the problem was obtained on the detailed study of the strategies and arrived with different alternatives. On that the best alternative is the designing of a plate which gives a permanent solution to the problem. In this project a plate is introduced in mould of performing machine to reduce thickness avoiding material losses. This project mainly deals with increase in productivity, time consumption and fulfilling customer satisfaction.
QoS Routing Protocol (QoRP) to Enhance Road Safety in VANETs
Authors:   Computer Science and Engineering, , KLS ,VDIT, Haliyal, India., Hotkar Damodar S. , Biradar Dr. S. R. ,   Information Science and Engineering , SDMCET, Dharwad, India.
Published: August 2019

Vehicular Ad Hoc Network (VANET) communication promises a vast array of applications ranging from road safety and driving comfort. Safety message broadcasting plays a significant role in highway safety in which the safety alert messages have to be delivered immediately to the vehicles located in the risk boundary area. Most of the current research attempt to select optimal relayer for safety message rebroadcasting. However, relayer selection models are not efficient, especially in a high-density VANET, as they cause a high delay in safety message delivery and lead to multiple accidents at the incident spot. To avert these issues, this work proposes a QoS Routing Protocol (QoRP) that aims to enhance the road safety in both sparse and dense VANETs.
Dual Band Half Psi Shaped Antenna for WLAN, Wi Fi and WiMAX Applications
Authors:   ECE, Visvodaya Engineering College/Kavali, India., Sura* Penchala Reddy , Reddy S Narayana ,   ECE, SV University/ Tirupati, India.
Published: August 2019

In the last few decades, the evolution in new-fashioned wireless communication systems has actuated augmented exploration on uncomplicated dual band antennas. In this paper, a dual-band half psi shaped antenna for WLAN, Wi-Fi and WiMAX appliances is designed and analyzed. The intended antenna constitutes a half psi shaped radiating patch on the cost effective FR4-substrate with 1.6 mm thickness. A 50 ohms feed line is employed to feed half psi shaped antenna. Here a preferable impedance matching is attained by truncating a portion of the ground surface. The intended antenna has the potential to resonate between the frequency bands of 1.88 GHz-2.75 GHz and 5.17 GHz-5.74 GHz with S11 below -10 dB. The design of the antenna and its behavior over various frequencies ranges is done with the use of HFSS. The proposed antenna has higher gains at two regions. The simulated antenna is also prototyped and a fine similarity is attained in between the simulated parameters and measured parameters.
Lifetime and Performance Improvement of HSS Drill Bit by Titania (TiO2) Nano-Coatings and Cryogenic Treatment
Authors:   Department of Mechanical Engineering, 3Vasavi College of Engineering, Hyderabad, India, Martha* Prabhu Kiran , Kishore K. ,   Department of Mechanical Engineering, Vasavi College of Engineering, Hyderabad, India, Ramadevudu* Gokarakonda. ,   Department of Physics, Vasavi College of Engineering, Hyderabad, India
Published: August 2019

The small and medium scale industry in drilling and cutting sector widely use cutting tools made by High Speed Steel (HSS). The improvement of lifetime of HSS drill bits helps these establishments to achieve product economy. The improvement in the performance and service lifetime of high-speed steel (HSS) twisted drill bits are studied by depositing Titanium dioxide (TiO2) nano-coatings using reactive dc magnetron sputtering Method. Pure titanium (99.99%) metal is used as target material for making nano-coatings in oxygen atmosphere. X-ray diffraction studies indicated change of phase of annealed samples compared to as-deposited coatings. X-ray reflection (XRR) measurements estimated nanocoating thickness on the HSS drill bit around 100nm. The lifetime of TiO2 nano-coated, and cryogenically treated nano-coated tools significantly improved compared to uncoated (bare) HSS drill bit. The tool life has been enhanced by about 16% when TiO2 nano-coatings were made on HSS drill bits. Further lifetime enhancement of 10% was observed when the nanocoated drill bit is given cryogenic treatment in liquid nitrogen. SEM images and EDS profiles are reported. The minimum surface roughness measured as 7.296x10-6m for TiO2 coated and cryo-treated HSS drill tool.
A Methodology for Automatic Detection and Classification of Pests using Optimized SVM in Greenhouse Crops
Authors:   Department of Computer Science and Engineering, GMR Institute of Technology, Rajam, Andhra Pradesh, India., Attada* Venkataramana , Katta Somesh ,   Department of Computer Science and Engineering, GMR Institute of Technology, Rajam, Andhra Pradesh, India
Published: August 2019

Digital revolution is taking place in every industry. The technologies namely Cloud Computing and the Internet of Things (IoT) are considered to be as a digital revolution. Comparatively with other industries Agriculture industry has less usage of these digital revolutionary technologies. In recent years Agriculture industry uses such type of digital revolution technologies to counterpart traditional practices which greatly influence the productivity. The IoT is set to push the future of farming to the next level by collecting the production data which includes weather and soil data, image data of crop, pests, etc. through internet enabled communication objects. Performing computation and providing advisory on this large scale of data that is collected by communication objects by Cloud Computing technology in terms of Leaf is point of interest which has infestation problem with biological organisms such as pests observed by naked eye is time consuming. We make use of digital revolution device like Unmanned Aerial Vehicle (UAV) which collects the data from user point of inter-est, Digital Image Processing techniques, Pattern recognition Algorithms for above stated problem to develop an advisory based cloud system which provides advisory based on detection of pests present on off-seasonal crops rose, lengthy type crops cucumber which are cultivated in new agricultural farming i.e. limited space structure namely Greenhouse.
Modeling and Simulation of Capacitive MEMSComb Accelerometer for sensitivity improvement with different Proof Mass Patterns
Authors:   Reaerch Scholor,Department of Electrical and Electronics Engineering, Annamalai University, Chidambaram, India., Ganta Anusha , Talam* Satyanarayana ,   Department of Electronics and Instrumentation Engineering, Lakireddy Bali Reddy College of Engineering (A), Mylavaram, India, Ganta Anusha ,   Department of Electronics and Instrumentation Engineering, Lakireddy Bali Reddy College of Engineering (A), Mylavaram, India, R Neela. ,   Department of Electrical and Electronics Engineering, Annamalai University, Chidambaram,India.
Published: August 2019

This Paper presents the sensitivity of a design for three dimensional comb type beam structure based accelerometer. Initially the basic comb accelerometer is developed and displacement sensitivity is observed by modeling and simulation. It is observed that accelerometer sensitivity is improved through the optimum selection of parameters via number of fingers, beam length, beam width, mass width, , spring constant. The movable proof mass is connected to two anchors. The movable fingers are connected to the two sides of the proof mass. Every movable finger consists of two fixed fingers are connected to the left and right respectively. Any acceleration along the direction on movable mass, it will induce the inertial force and deflect the beam. Hence the capacitance will performed in between fixed and movable fingers. By changing the parameters like fingers width, number of fingers, proof mass shape, and spring constant the displacement is changed .By adjusting these parameters corresponding sensitivity can be improved.