bluuebunny/crossref_metadata_2025 huggingface dataset:
When Should Tumor Genomic Profiling Prompt Consideration of Germline Testing?
Authors: DeLeonardis Kim , Hogan Lauren , Cannistra Stephen A. , Rangachari Deepa , Tung Nadine
Published: September 2019

Somatic genomic testing is rapidly becoming an integral part of care for patients with metastatic cancer. Extrapolation of these results beyond personalized cancer therapy is a skill being demanded of practicing oncologists without prior specialty in genetics. Up to 12% of tumor genomic profiling reports will reveal a germline pathogenic variant. Recognition of these germline variants is essential not only for optimal care of the patient with cancer but also to initiate cascade genetic testing in at-risk family members who also may carry the familial mutation. This article provides a concise and methodical, evidence-based strategy to guide oncology providers about how to identify genes associated with an inherited predisposition for cancer, determine the pathogenicity of variants reported within those genes, and understand the likelihood that these variants are of germline origin in a particular patient with cancer. Case examples are provided to illustrate clinical scenarios and facilitate application of the proposed approach.
Progesterone and Breast Cancer
Authors: Trabert Britton , Sherman Mark E , Kannan Nagarajan , Stanczyk Frank Z
Published: September 2019

Synthetic progestogens (progestins) have been linked to increased breast cancer risk; however, the role of endogenous progesterone in breast physiology and carcinogenesis is less clearly defined. Mechanistic studies using cell culture, tissue culture, and preclinical models implicate progesterone in breast carcinogenesis. In contrast, limited epidemiologic data generally do not show an association of circulating progesterone levels with risk, and it is unclear whether this reflects methodologic limitations or a truly null relationship. Challenges related to defining the role of progesterone in breast physiology and neoplasia include: complex interactions with estrogens and other hormones (eg, androgens, prolactin, etc.), accounting for timing of blood collections for hormone measurements among cycling women, and limitations of assays to measure progesterone metabolites in blood and progesterone receptor isotypes (PRs) in tissues. Separating the individual effects of estrogens and progesterone is further complicated by the partial dependence of PR transcription on estrogen receptor (ER)α-mediated transcriptional events; indeed, interpreting the integrated interaction of the hormones may be more essential than isolating independent effects. Further, many of the actions of both estrogens and progesterone, particularly in “normal” breast tissues, are driven by paracrine mechanisms in which ligand binding to receptor-positive cells evokes secretion of factors that influence cell division of neighboring receptor-negative cells. Accordingly, blood and tissue levels may differ, and the latter are challenging to measure. Given conflicting data related to the potential role of progesterone in breast cancer etiology and interest in blocking progesterone action to prevent or treat breast cancer, we provide a review of the evidence that links progesterone to breast cancer risk and suggest future directions for filling current gaps in our knowledge.
AMPK subunits harbor largely non-overlapping genetic determinants for body fat mass, glucose- and cholesterol metabolism
Authors: Randrianarisoa Elko , Lehn-Stefan Angela , Krier Johannes , Böhm Anja , Heni Martin , Hrabě de Angelis Martin , Fritsche Andreas , Häring Hans-Ulrich , Stefan Norbert , Staiger Harald
Published: September 2019

Context

AMP-activated protein kinase (AMPK) is a heterotrimeric enzyme and central regulator of cellular energy metabolism. The impact of single nucleotide polymorphisms (SNPs) in all seven subunit genes on adiposity, glucose- and lipid metabolism has not been systematically studied yet.

Objective

To analyze the associations of common SNPs in all AMPK genes, and of different scores thereof, with adiposity, insulin sensitivity, insulin secretion, blood glucose, total-, LDL- and HDL-cholesterol and triglycerides.

Study Design and Methods

A cohort of 2789 non-diabetic subjects from the Tübingen Family study of type-2 diabetes, metabolically characterized by oral glucose tolerance test and genotyped by genome-wide SNP array was analyzed.

Results

We identified largely non-overlapping SNP sets across four AMPK genes (PRKAA1, PRKAA2, PRKAG2, PRKAG3) associated with adiposity, insulin sensitivity, insulin secretion, blood glucose, total-/LDL-cholesterol or HDL-cholesterol, respectively. A genetic score of body-fat-increasing alleles revealed per-allele effect sizes on BMI of +0.22 kg/m² (p=2.3·10-7), insulin sensitivity of -0.12·1019 L²/mol² (p=9.9·10-6) and 2-h blood glucose of +0.02 mmol/L (p=0.0048). Similar effects on blood glucose were observed with scores of insulin-sensitivity-reducing, insulin-secretion-reducing and glucose-raising alleles, respectively. A genetic cholesterol score increased total- and LDL-cholesterol by 1.17 mg/dL per allele (p=0.0002 and p=3.2·10-5, respectively), and a genetic HDL score decreased HDL-cholesterol by 0.32 mg/dL per allele (p=9.1·10-6).

Conclusions

We describe largely non-overlapping genetic determinants in AMPK genes for diabetes-/atherosclerosis-related traits which reflect the metabolic pathways controlled by the enzyme. Formation of trait-specific genetic scores revealed additivity of allele effects, with body-fat-raising alleles reaching a marked effect size.
C. elegans synMuv B proteins regulate spatial and temporal chromatin compaction during development
Authors: Costello Meghan E. , Petrella Lisa N.
Published: September 2019

Tissue-specific establishment of repressive chromatin through creation of compact chromatin domains during development is necessary to ensure proper gene expression and cell fate. Caenorhabditis elegans synMuv B proteins are important for the soma/germline fate decision and mutants demonstrate ectopic germline gene expression in somatic tissue, especially at high temperature. We show that C. elegans synMuv B proteins regulate developmental chromatin compaction and that the timing of chromatin compaction is temperature sensitive in both wild type and synMuv B mutants. Chromatin compaction in mutants is delayed into developmental time periods when zygotic gene expression is upregulated and demonstrates an anterior-to-posterior pattern. Loss of this patterned compaction coincides with the developmental time period of ectopic germline gene expression, which leads to a developmental arrest in synMuv B mutants. Finally, accelerated cell division rates at elevated temperature may contribute to a lack of coordination between expression of tissue specific transcription programs and chromatin compaction at high temperature. Thus, chromatin organization during development is regulated both spatially and temporally by synMuv B proteins to establish repressive chromatin in a tissue-specific manner to ensure proper gene expression.
The molecular basis of LST-1 self-renewal activity and its control of stem cell pool size
Authors: Haupt Kimberly A. , Enright Amy L. , Ferdous Ahlan S. , Kershner Aaron M. , Shin Heaji , Wickens Marvin , Kimble Judith
Published: September 2019

PUF RNA-binding proteins have diverse roles in animal development, with a broadly conserved role in stem cells. Two paradigmatic PUF proteins, FBF-1 and FBF-2, promote both self-renewal and differentiation in the C. elegans germline. The LST-1 protein is a pivotal regulator of self-renewal and oncogenic when mis-expressed. Here we demonstrate that LST-1 self-renewal activity resides within a predicted disordered region that harbors two KXXL motifs. We find that the KXXL motifs mediate LST-1 binding to FBF, and that point mutations of these motifs abrogate LST-1 self-renewal activity. The LST-1–FBF partnership is therefore critical to stem cell maintenance and a key element in the FBF regulatory network. A distinct region within LST-1 determines its spatial expression and size of the GSC pool. Most importantly, the molecular understanding of how an IDR-rich protein works in an essential partnership with a conserved stem cell regulator and RNA-binding protein suggests broad new avenues for combinatorial control.
Stock or Print? Impact of 3-D Printing on Spare Parts Logistics
Authors: Song Jing-Sheng , Zhang Yue
Published: September 2019

We present a general framework to study the design of spare parts logistics in the presence of three-dimensional (3-D) printing technology. We consider multiple parts facing stochastic demands and adopt procure/manufacture-to-stock versus print-on-demand to highlight the main difference of production modes featured in traditional manufacturing and 3-D printing. To minimize long-run average system cost, our model determines which parts to stock and which to print. We find that the optimal 3-D printer’s utilization increases as the additional unit cost of printing declines and the printing speed improves. The rate of increase, however, decays, demonstrating the well-known diminishing returns effect. We also find the optimal utilization to increase in part variety and decrease in part criticality, suggesting the value of 3-D technology in tolerating large part variety and the value of inventory for critical parts. By examining the percentage cost savings enabled by 3-D printing, we find that, although the reduction in printing cost continuously adds to the value of 3-D printing in a linear fashion, the impact of the improvement of printing speed exhibits S-shaped growth. We also derive various structural properties of the problem and devise an efficient algorithm to obtain near optimal solutions. Finally, our numerical study shows that the 3-D printer is, in general, lightly used under realistic parameter settings but results in significant cost savings, suggesting complementarity between stock and print in cost minimization.

This paper was accepted by Victor Martínez-de-Albéniz, operations management.
Effectiveness Of Active Learning Method Quiz Team Type On Student Learning Outcomes In Subject Ohm Law In SMA Negeri 1 Pundong
Authors: Raisal Abu Yazid , Suwondo Nanang
Published: September 2019

This study aims to measure the increase in student learning outcomes from cognitive aspects and student activity between active quiz type learning methods and conventional methods. The sampling technique is non-random sampling. Data was collected using the pre-test and post-test for cognitive aspects while the affective aspects used the observation. Analysis of the data used the normality test, homogeneity test, and hypothesis testing. The hypothesis test used is a two-party t test. The results show that tcount= 7.273 > ttable= 2.01 at a significant level of 5%. It means that there are significant differences for cognitive aspects between learning outcomes using the team quiz type and conventional methods of active learning methods. Overall the team quiz method is more effective for improving student learning outcomes from cognitive aspects, and student activities.
First impressions: assessing the horse for soundness
Authors: Meers-Rainger Clive
Published: September 2019

Clive Meers-Rainger Discusses modern shoeing techniques to maintain soundness
Latest laminitis research
Authors: Witherow Briony
Published: September 2019

Briony Witherow MSc RNutr. FHEA Practical Equine Nutrition, discusses what's new in laminitis research and the latest recommendations
Evaluating pressure redistribution surfaces for the occiput
Authors: Werthman Emily , Lynch Theresa , Ware Linda , Caffrey Julie
Published: September 2019

Objective:

Patients hospitalised in the Burn Intensive Care Unit are at increased risk of pressure ulcers (PU; also known as pressure injuries). While effective methods exist to offload pressure from other areas, offloading the head is difficult, especially with facial or head burns. An increase in occipital PUs prompted a review of practices for offloading the head in the Burn Intensive Care Unit.

Method:

A multidisciplinary team (MDT) of physicians, occupational therapists and nurses evaluated several devices used to prevent occipital PUs using a pressure mapping device. Pressure was measured using the SensorEdge Measure X device. The pressure mapping device provides a real-time graphic representation of pressure to the body area studied, in this case the occiput. In addition, the SensorEdge allows for numeric data to be exported to Excel format.

Results:

Our data showed that the occipital pressure was observed in our health volunteer using a fluidised gel positioner using pressure mapping. As a result of this we stopped using other pillows and went to exclusive use of the fluidised gel positioner. Reimplementation and consistent use of a fluidised gel positioner resulted in decreasing occipital PUs from nine to zero.

Conclusion:

The use of a fluidised gel positioner should be considered in other critical care environments to reduce the prevalence of hospital acquired occipital PUs.
Benefits of barbed suture utilisation in gastrointestinal anastomosis: a systematic review and meta-analysis
Authors: Wiggins T , Majid MS , Markar SR , Loy J , Agrawal S , Koak Y
Published: September 2019

Introduction

Anastomosis formation constitutes a critical aspect of many gastrointestinal procedures. Barbed suture materials have been adopted by some surgeons to assist in this task. This systematic review and meta-analysis compares the safety and efficacy of barbed suture material for anastomosis formation compared with standard suture materials.

Methods

An electronic search of Embase, Medline, Web of Science and Cochrane databases was performed. Weighted mean differences were calculated for effect size of barbed suture material compared with standard material on continuous variables and pooled odds ratios were calculated for discrete variables.

Findings

There were nine studies included. Barbed suture material was associated with a significant reduction in overall operative time (WMD: -12.87 (95% CI = -20.16 to -5.58) (P = 0.0005)) and anastomosis time (WMD: -4.28 (95% CI = -6.80 to -1.75) (P = 0.0009)). There was no difference in rates of anastomotic leak (POR: 1.24 (95% CI = 0.89 to 1.71) (P = 0.19)), anastomotic bleeding (POR: 0.80 (95% CI = 0.29 to 2.16) (P = 0.41)), or anastomotic stricture (POR: 0.72 (95% CI = 0.21 to 2.41) (P = 0.59)).

Conclusions

Use of barbed sutures for gastrointestinal anastomosis appears to be associated with shorter overall operative times. There was no difference in rates of complications (including anastomotic leak, bleeding or stricture) compared with standard suture materials.
A simple ex vivo model of human renal allograft preservation using the gonadal vein
Authors: Ries WP , Marie Y , Patel K , Turnbull C , Smith TB , Jamil NSM , Caldwell H , Telfer R , Neil DAH , Nath J , Inston NG
Published: September 2019

Introduction

Hypothermic machine perfusion, an organ preservation modality, involves flow of chilled preservation fluid through an allograft’s vasculature. This study describes a simple, reproducible, human model that allows for interrogation of flow effects during ex vivo organ perfusion.

Materials and methods

Gonadal veins from deceased human renal allografts were subjected to either static cold storage or hypothermic machine perfusion for up to 24 hours. Caspase-3, Krüppel-like factor 2 expression and electron microscopic analysis were compared between ‘flow’ and ‘no-flow’ conditions, with living donor gonadal vein sections serving as negative controls.

Results

The increase in caspase-3 expression was less pronounced for hypothermic machine-perfused veins compared with static cold storage (median-fold increase 1.2 vs 2.3; P < 0.05). Transmission electron microscopy provided ultrastructural corroboration of endothelial cell apoptosis in static cold storage conditions. For static cold storage preserved veins, Krüppel-like factor 2 expression diminished in a time-dependent manner between baseline and 12 hours (P < 0.05) but was abrogated and reversed by hypothermic machine perfusion (P < 0.05).

Conclusions

Our methodology is a simple, reproducible and successful model of ex vivo perfusion in the context of human organ preservation. To demonstrate the model’s utility, we establish that two widely used markers of endothelial health (caspase-3 and Krüppel-like factor 2) differ between the flow and no-flow conditions of the two predominant kidney preservation modalities. These findings suggest that ex vivo perfusion may mediate the induction of a biochemically favourable endothelial niche which may contribute tohypothermic machine perfusion’s association with improved renal transplantation outcomes.
Sarcopenia does not affect postoperative complication rates in oesophageal cancer surgery: a systematic review and meta-analysis
Authors: Schizas D , Frountzas M , Lidoriki I , Spartalis E , Toutouzas K , Dimitroulis D , Liakakos T , Mylonas KS
Published: September 2019

Introduction

The high morbidity and mortality rates after oesophagectomy indicate the need for rigorous patient selection and preoperative risk assessment. Although muscle mass depletion has been proposed as a potential prognostic factor for postoperative complications and decreased survival in gastrointestinal cancer patients, available data are conflicting. The purpose of the present meta-analysis is to determine whether sarcopenia predicts postoperative outcomes in patients undergoing oesophagectomy.

Methods

The databases MEDLINE, SCOPUS, Clinicaltrials.gov, CENTRAL and Google Scholar were searched for studies reporting on the effect of sarcopenia on postoperative outcomes following oesophageal cancer surgery. Outcomes included surgical complications, anastomotic leakage, respiratory complications, cardiovascular complications, postoperative infections, major complications and overall complications. The random effects model (DerSimonian–Laird) was used to calculate pooled effect estimates when high heterogeneity was encountered, otherwise the fixed-effects (Mantel–Haenszel) model was implemented.

Findings

A total of eight studies involving 1488 patients diagnosed with oesophageal cancer and who underwent oesophagectomy were included in the meta-analysis. The presence of sarcopenia did not significantly increase the rate of surgical complications (odds ratio, OR, 0.86, 95% confidence interval, CI, 0.40–1.85), anastomotic leakage (OR 0.75, 95% CI 0.42–1.35), respiratory complications (OR 0.56, 95% CI 0.21–1.48), cardiovascular complications (OR 0.94, 95% CI 0.31–2.83), postoperative infection (OR 1.14, 95% CI 0.52–2.50), major complications (OR 0.81, 95% CI 0.23–2.82) or overall postoperative complications (OR 0.80, 95% 0.32–1.99).

Conclusion

Sarcopenia does not seem to affect postoperative complication rates of patients undergoing oesophagectomy for oesophageal cancer. Future research should focus on determining whether prognosis differs according to muscle mass in this patient population.
Traumatic thoracoabdominal hernia repair using a novel chest-wall reconstruction technique: a case report
Authors: Aladaileh M , O’Driscoll-Collins A , O’Keeffe F , Conneely JB , Redmond K
Published: September 2019

Thoracoabdominal hernia following blunt trauma is extremely rare. Abdominal viscera are more likely to herniate into the thorax if there is traumatic diaphragmatic rupture. We report the case of a patient presenting with a traumatic thoracoabdominal hernia containing part of the right lobe of the liver and the hepatic flexure of the colon. The hernia migrated cranially, to protrude through a seventh intercostal defect despite the diaphragm remaining fully intact. The need for early multispecialty (thoracic and hepatobiliary) surgical repair is highlighted, with improvements in surgical outcome for a complex trauma case by using a novel chest-wall reconstruction technique.
Laparoscopic therapy of the coeliac artery compression syndrome: a critical analysis of the current standard procedure
Authors: Sahm M , Otto R , Pross M , Scholbach T , Mantke R
Published: September 2019

Introduction

Median arcuate ligament syndrome has been known anatomically for approximately 100 years and results from a compression of the coeliac axis by fibrous attachment of the diaphragmatic crura. Owing to the rarity of the disease and limited available data, many aspects of treatment are controversial. Currently, laparoscopic decompression is considered by several authors as standard surgical procedure. We present an analysis of the clinical routine of MALS therapy.

Methods

We conducted a prospective observational trial in patients with MALS between March 2016 and August 2018, in which clinical symptoms, diagnostic evaluation, procedures with complication analysis and follow-up data were recorded.

Results

A total of 18 patients (12 female, 6 male) with MALS, aged between 15 and 65 years, were included in this study. All patients presented with long-standing abdominal pain. Preoperative Doppler ultrasonography showed a flow velocity of the coeliac artery averaging 289.9cm/second in mid-position of the diaphragm, 285.9cm/second in expiration and 199.0cm/second in inspiration. All operated patients underwent laparoscopic decompression; two patients received an angiographic intervention. Postoperatively, a significant decrease of the flow velocity in mid-position of the diaphragm was detected (P = 0.018). At follow-up after 5.2 months, 50.0% of the patients were pain-free, 37.5% reported symptomatic relief and 12.5% showed evidence for a recurrence.

Conclusion

MALS is challenging both diagnostically and therapeutically. Laparoscopy with release of the median arcuate ligament is an essential part of the therapy and can be confirmed by Doppler ultrasonography. Disease outcome is also influenced by several predictive factors.
Differentiating Asymptomatic Bacteriuria From Urinary Tract Infection in the Pediatric Neurogenic Bladder Population: NGAL As a Promising Biomarker
Authors: Gupta Sudipti , Preece Janae , Haynes Andria , Becknell Brian , Ching Christina
Published: September 2019

Objective: To evaluate whether urinary antimicrobial peptides (AMPs) can discriminate between asymptomatic bacteriuria (ASB) and urinary tract infection (UTI) in pediatric patients with neurogenic bladder (NGB). Design/Methods: Bladder urine was collected from pediatric patients (≤18 years old) with NGB without augmentation cystoplasty. Patients were divided into the following groups based on symptomatology and results of urinalysis/urine culture: (a) UTI, (b) ASB, and (c) sterile. Urine AMPs β defense 1 (BD-1), neutrophil gelatinase-associated lipocalin (NGAL), cathelicidin (LL-37), hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein (HIP/PAP), and human α defensin 5 (HD-5) were compared between groups by enzyme-linked immunosorbent assays. In addition, urines from pediatric controls without NGB or UTI were also analyzed. Significance was determined using Student's t test for parametric or Mann-Whitney U test for nonparametric data. A p value of <.05 was considered significant. Results: Thirty-six patients with NGB from a spinal dysraphism were evaluated: UTI, n = 6; ASB, n = 18; sterile, n = 12. These groups did not differ significantly by age but did significantly differ by gender ( p = .0139). NGAL significantly differed between UTI and ASB groups (median 38.5 ng/mg vs 15.5 ng/mg, respectively; p = .0197) with a sensitivity and specificity of 82.4% and 83.3%, respectively. HIP/PAP, BD-1, HD-5, LL-37, and NGAL levels were all significantly higher in sterile NGB urines compared to 17 non-NGB pediatric controls ( p < .0001, p = .0020, p = .0035, p = .0006, and p = .0339, respectively). Conclusion: All five urinary AMPs evaluated were significantly elevated in NGB patients compared to controls. NGAL levels may help differentiate between UTI and ASB in pediatric NGB patients.
Positive Emotional Support in Premutation Carrier Mothers of Adolescents and Adults With Fragile X Syndrome: Gene by Environment Interactions
Authors: Hartley Sigan L. , DaWalt Leann S. , Hong Jinkuk , Greenberg Jan S. , Mailick Marsha R.
Published: September 2019

We examined the benefit of emotional support on daily health in premutation carrier mothers of adolescents and adults with fragile X syndrome (n = 114), and whether this benefit was moderated by the mother's genetic status (FMR1 CGG repeat length). In an 8-day daily diary, maternal daily health was assessed subjectively through self-reported number of physical health symptoms and physiologically via cortisol awakening response. Multilevel lagged-day models indicated that premutation carrier mothers with midrange CGG repeats derived less health benefit from a day with high positive emotional support than those with lower or higher numbers of repeats within the premutation range. The data support the influence of both genetic and environmental influences on the health of this population.
Sustaining Sherpa language and culture in New York
Authors: Sherpa Pasang Yangjee
Published: September 2019

Sherpas moved from their original homeland in Solukhumbu district of Nepal to adjacent mountain districts and later to urban centres such as Kathmandu and Darjeeling over several generations. By the end of the twentieth century, many had also moved permanently to North American and European countries. Now, after Kathmandu in Nepal, the largest concentration of Sherpas can be found in Queens, New York, and the surrounding boroughs. The case of New York Sherpas is unique because for the first time in history, thousands of Sherpas from different parts of the Himalayas are living together and sharing a new home. Earlier, these Sherpas were separated for generations by geographic obstacles, great distances and international boundaries. Although the process of adapting to a new sociocultural environment is not novel, this article argues that the kinds of challenges and opportunities that New York has presented for the Sherpas are different from their experience elsewhere.

Sherpas are acutely aware of the risk of losing their language and culture in their new homes in the United States, especially when it comes to transmitting cultural knowledge to the next generation. Many are therefore actively involved in the preservation of their language and culture through community mobilization in the form of kyidugs.1 Based in different cities across the United States, Sherpa kyidugs uniformly emphasize the significance of promoting their language and culture within the community. A shared place of worship and gathering is key to Sherpas’ efforts to preserve and practice their culture, and so the kyidugs recognize the need for a community building, where they can gather to perform religious rituals and festivals, offer language classes or simply gather.
Ni kaakiihtwaamaan itootamihk waapamishoon aan mii wiichaytoowuk: I am practice reflected in relationships
Authors: Bouvier Victoria
Published: September 2019

Michif-Métis denotes a way of life that is bound to specific political, historical, cultural and linguistic ethos, with specific ties to complex kinship systems with humans, earth and cosmological beings. As a Michif woman, growing up away from my relatives and land in Manitoba, I had always felt that the tether that connects my spiritual being to my ancestors was frayed because I did not grow up in a close-knit Michif community. I realized that it is not necessarily where you are that matters, but it is about how we are practising the relationships in the places we find ourselves. Through an animate and kinetic journey expressed by layering text and photos, this article is an attempt to peel back the layers and reveal some of the nuances and con/textualizations of being and becoming Michif. I explore my own expressions and practices of my self-understandings through my interactions within places in and near Mohkinstsis, Calgary, that allow me to express and affirm ni kaakiihtwaamaan itootamihk waapamishoon aan mii wiichaytoowuk – ‘I am practice reflected in relationships’.
The improvement in service quality of small-scale food service businesses in Surabaya
Authors: Kristanti Monika
Published: September 2019

Two types of small-scale food service business existing in Surabaya are hawker centres and depots. Generally, depots and hawker centres are managed unprofessionally as the owner does not pay much attention to the service quality. Conversely, nowadays customers pay more attention to the service quality. Based on a survey, it was identified that hawker centres and depots are lacking in three aspects: (1) hygiene and sanitation, and (2) poor knowledge among staff in terms of both service quality and (3) grooming. Training was provided to the staff on food and personal hygiene; knowledge of food safe packaging; and how to provide excellent services. On the basis of feedback from the owner and the customers, it was found that these activities had positive impacts on depots, hawker centres and the customers. Hawker centres and depots could improve their staffs’ service quality so that in the end, customers feel satisfied visiting them. Since students performed these activities, they have also had a positive impact on them. By interacting with the owner and the staff at the hawker centres and depots, the students learned to be humble and open-minded, to interact with people from different backgrounds of education and economy, to have self-motivation and to not underestimate other people. Most importantly, the students realized that they should be thankful for what they have.
The damage that decorates
Authors: Bell Louise
Published: September 2019

A wounded city can yield both sites of affect and relic-like objects. The vestiges of Plymouth's blitzed past is inscribed within the pattern and patina of place. This inscription can become overlooked with the passage of time and the fast movement of people through cityscape. By slow looking, stretching a glance into an encounter, witness marks have opportunity to communicate and temporally suture the urban landscape.

In this paper, I unravel the terms 'decoration' and 'ornamentation' through the lens of trauma studies and present occurrences of disrepair as worthy of consideration. I put forward how damage can behave as decoration and why such illustrative terminology is empathetic to the structures decorated by it. Focusing on a selection of ceramics damaged by the aerial bombardment, I explore the ways these artefacts speak to the present through their scars and how they are mimetic of their wounded city. Through a practice-based Ph.D., I employ illustration as a historiographic arts practice and attempt to unlock other ways of knowing which are always already at work within a city's fragments and disregarded sites.
Defining contemporary metal music: Performance, sounds and practices
Authors: Mynett Mark
Published: September 2019

Contemporary metal music (CMM) features, usually down-tuned, harmonically distorted timbres, and from a performance perspective regularly contains fast and frequently complex subdivisions, as well as highly synchronized instrumentation. The combination of these elements results in a significant concentration of dense musical sound usually referred to as ‘heaviness’. From a performance, sounds, practices and production aesthetics perspective, this article proposes the broad musical parameters for CMM’s heaviness, and from this viewpoint likewise seeks to distinguish CMM from traditional heavy metal music.
Heavy metal music and managing mental health: Heavy Metal Therapy
Authors: Quinn Kate
Published: September 2019

Heavy metal music was thought to be associated with mental health difficulties in early research. However, fans and performers often describe it as helpful for managing well-being, and more recent research proposes that it may have a role in terms of processing emotions and/or as a positive community influence. This article describes the development and theoretical background of the online peer support project Heavy Metal Therapy, which is informed by ideas from the recovery movement, voice dialogue and narrative practice. It describes the current facilitation/moderation process for the project including the use of recovery stories and blogs, and the dissemination of recovery model ideas via social media for people who find metal music helpful for managing mental health and well-being.
Going online to be a lesbian: AfterEllen, Vice Versa, The Ladder and queer (?) theorizing in discursive spaces
Authors: Rush Josie
Published: September 2019

By constructing a lineage of mediated discourse in which queer women theorize their spaces and identities, this article argues for the significant place of communication technologies as venues for queer women’s theoretical discussions. Specifically, it analyses content from AfterEllen, a website devoted to popular culture and media for lesbian and bisexual women, connecting the site to two twentieth-century lesbian periodicals, Vice Versa and The Ladder, ultimately arguing for a conception of the discourse produced in these spaces as a type of proto-queer theory. In each space, queer women reject the fictive wholeness proffered by systems of heteronormativity through their critiques of mainstream society and cultivation of representation and community. However, this article also analyses the dangers of theory, as spaces like AfterEllen theorize a lesbian subjectivity that denigrates and dismisses trans lesbians. Utilizing convergence theory, this article additionally argues that heralding the web as the first liberating space of its kind for LGBT individuals obfuscates a rich history of investment in and dependence on communication networks for identity and community formation.
La cultura y la mitología en el cine brasileño de Glauber Rocha
Authors: Valverde Da Silva Ana Luiza
Published: September 2019

Glauber Rocha propone dos películas que reflexionan sobre la distribución social y el sistema económico vigente en el Brasil de los años 1960. emDeus e o diabo na terra do sol/em, de 1964, se integra en el contexto de la estética del hambre y es signo del cine revolucionario, vanguardista y con una visión cinematográfica anterior al golpe militar. En cambio, emAntonio Das Mortes/em, de 1969, nace en medio de las transformaciones desencadenadas por el movimiento emTropicália/em y de la represión de la libertad de expresión creada por la dictadura brasileña. Esa investigación está fundamentada en la representación empleada por Glauber Rocha para destacar la cultura y la mitología en ambas películas como una forma de reivindicación social.
Estudiar es actividad común externa y siempre educamos con la actividad. Una aproximación desde la perspectiva mesoaxiológica
Authors: Touriñán López José Manuel
Published: September 2019

Mesoaxiológica quiere decir comprender el medio valorado. Y en Pedagogía, la perspectiva mesoaxiológica significa comprender el medio valorado como educativo. Estudiar es una actividad y, en primer lugar, tiene valor pedagógico porque se usa para educar; es un medio para una finalidad especificada. Pero además, estudiar tiene su propia finalidad, vinculada conceptualmente al término ‘estudiar’; su finalidad es dominar-lograr saber aquello que se estudia. En perspectiva mesoaxiológica, no es lo mismo valorar la actividad de estudiar, porque es un medio para educar, que valorar la actividad de estudiar, porque la actividad en sí educa; es decir, no significa lo mismo para la Pedagogía decir que estudiamos para educarnos (para lograr finalidades educativas), que decir que, al ejecutar la actividad de estudiar, nos educamos.  Si esa diferencia se significa, estudiar no solo tiene valor propedéutico, sino valor educativo en sí, porque la propia actividad de estudiar, al ser ejecutada, nos educa. En este caso, lo importante no es qué cosa estudio y cuál es la finalidad instrumental del estudio, sino que lo importante es la actividad misma de estudiar, porque me ‘educo con’ la actividad, al ejecutarla, y no solo por la meta educativa que persigo, sino por usar esa actividad.
Uma skholé para professores: o estudo como dimensão constitutiva do ofício de professor
Authors: Rechia Karen Christine , Cubas Caroline Jacques
Published: September 2019

A presente proposição reivindica o estudo como elemento constitutivo e basilar do ofício de professor. Neste texto, nos dedicaremos a pensá-lo a partir de atividades desenvolvidas no escopo da formação docente inicial, nossa área de atuação (uma, professora de um curso de licenciatura em uma universidade pública e a outra, professora de uma instituição escolar pública de ensino fundamental e médio). Tal atuação nos possibilita indicar, em um primeiro momento, certas incongruências no discurso acerca da profissionalização/ burocratização do professor. Neste sentido, destacamos que a formação docente inicial tem cada vez mais se fundamentado em uma lógica de aprendizagem, de desenvolvimento de competências e habilidades voltadas, na maioria das vezes, à garantia de inserção no mercado de trabalho e atuação profissional adaptada a lógicas produtivistas. Diante disto, nos propomos a pensar, no interior de uma noção de skholé – de um tempo livre e de um espaço público -, as possibilidades de estudo do ofício não somente em seus conteúdos específicos e metodologias, mas, especialmente, através de seus gestos, maneiras e modos de fazer. Por isso o foco não está num método docente, mas na ativação de uma experimentação desenvolvida através de observações, pensamentos e práticas que coloquem a escola – e por conseguinte a sala de aula - como matéria de estudo. Portanto o estágio, esta etapa fundamental da formação docente inicial, constitui-se em um tempo e espaço de atenção à escola. Tem por assunto o ofício do professor e por matéria os elementos que constituem este ofício. Para tanto, amparamo-nos particularmente nos escritos de Jan Masschelein e Marteen Simons sobre a noção de escolar e de Jorge Larrosa, sobre o ofício de professor.
CZECH WW2 CONCRETE FORTIFICATIONS: CORROSION PROCESSES AND REMEDIATION METHOD BASED ON CRYSTALLIZING COATING
Authors: Pazderka Jiří , Reiterman Pavel
Published: September 2019

Concrete is a relatively new structural material, hence the remediation of concrete structures is very rare. There are a lot of concrete fortifications in the Czech Republic, which were built just before WW2. These bunkers formed a long defensive line along the Czechoslovak borders as a protection against Hitler’s army. Today, after 80 years, many of the bunkers are listed as Czech national technical monuments with a strict protection of their historical authenticity. The article describes the technical survey and the possible conservation method of a selected concrete fortification, which exhibits a number of moisture related problems. The studied two-storey, heavily fortified bunker is situated close to the northern border of the Czech Republic, former Czechoslovakia. A detailed survey of the building includes the analysis of the interior environment parameters and laboratory testing of the used concrete. A long-term diagnosis identified the main problem, which lies in the inhomogeneity of the used concrete and the relating massive water ingress. However, the monitored bunker currently does not serve as a military structure and, therefore, a simple solution to improve the internal environment was suggested on the basis of the conducted measurements. With respect to the main causes of failures, the authors suggested a conservation method based on using a crystallizing coating. The suitability of the method was first verified under laboratory conditions and then also on the real bunker.
A MULTIPHASE FLOW LOOP DESIGN FOR INVESTIGATING THE PARTIAL PHASE SEPARATION IN A PIPE TEE
Authors: Saieed Ahmed , Memon Zeeshan Qadir , Tran Minh Cong , King Soon William Pao
Published: September 2019

This article presents a design and commissioning of a multiphase flow loop, which was developed for scrutinizing the partial phase separation characteristics of pipe Tees. Its length is 9m and its primary diameter is 0.078m (3 inches). For the ease of modification, its design was kept modular, so that it could be used for testing various other pipe profiles. To validate this flow loop, the separation of a stratified-wavy flow was tested in a regular diameter ratio pipe Tee, and the gathered results were compared with previously published data. A good agreement was observed between the two data sources, which suggests that this flow loop is suitable for a further experimentation.
Children's Perception of Wolverine in the North Slave Region of the Northwest Territories, Canada
Authors: Bonamy Morgane , Harbicht Andrew B. , Herrmann Thora Martina
Published: September 2019

The public’s level of knowledge and opinions towards certain species can greatly impact their willingness to support present or future conservation or management programs. When public opinion is mixed, as is often the case with wild carnivores, an accurate assessment of perceptions and knowledge can identify areas of concern and help guide public outreach efforts. When such outreach programs focus on children they can be particularly effective for two reasons: 1) the opinions of children towards wild animals are often more flexible than the ingrained beliefs of adults, and 2) it is the younger generation that will be called upon to support long-term conservation efforts in the future. To assess the degree of knowledge and the current state of opinion among children towards a little known and often negatively perceived Arctic species, the wolverine (Gulo gulo), we conducted surveys with school children between the ages of 8 – 12 years old in seven schools within the North Slave Region of the Northwest Territories. Results from 151 completed surveys confirm that the majority of children lack general knowledge about this species, though the overall level of knowledge was higher in small, rural communities than the larger capital city of Yellowknife. Negative values were among the most commonly expressed values we observed, but so too was an appreciation for the ecological role that wolverines play in nature. The results of this study can be used to implement new educational programs aimed at increasing the overall level of acceptance of the wolverine and similar carnivores, and to encourage the public’s willingness to support conservation efforts for this often negatively perceived species.
Accelerated Springtime Melt of Snow on Tundra Downwind from Northern Alaska River Systems Resulting from Niveo-aeolian Deposition Events
Authors: De Boer Gijs , Cox Christopher J. , Creamean Jessie M.
Published: September 2019

It is well known that light-absorbing particulate matter (PM) enhances absorption of sunlight when deposited on ice and snow. Such increased absorption is due to a reduction in surface albedo, resulting in accelerated melt of frozen surfaces. In isolation, earlier melt enhances Arctic warming since dark surfaces underlying snow and ice are exposed and absorb additional solar energy. Here, we combine various observational tools to demonstrate that aeolian deposition of PM along fluvial features on the North Slope of Alaska resulted in a notable reduction of surface albedo in the spring of 2016, from values typical for snow (~0.8) to around 0.35 on average. This reduction resulted in accelerated snow and ice melt by up to three weeks compared to unaffected areas. This phenomenon was observed to some degree in 12 other years dating back to 2003. Deposition generally was found to occur near particular sections of the rivers, with several areas affected by events in multiple years. In all years, the deposition is attributed to high wind events. The extreme case in 2016 is linked to unusually strong and extraordinarily persistent winds during April. The deposited material is thought to be the natural sediment carried by the rivers, resulting in a seasonally replenished source of PM. These findings indicate a previously unreported impact of both fluvial and atmospheric processes on the seasonal melt of northern Alaska rivers.
Mapas conceituais das medidas cefalométricas Padrão USP. Parte 2: arcadas dentárias, bases apicais, comportamento morfodiferencial do incisivo inferior em relação às bases apicais e padrão do perfil mole
Authors: Sella Rodrigo Castellazzi , Ursi Wagner José Silva , Sella Karina Fancio
Published: September 2019

Essa segunda parte do presente artigo tem como objetivo apresentar os mapas conceituais das medidas relativas às arcadas dentárias, bases apicais, comportamento morfodiferencial do incisivo inferior em relação à maxila e à mandíbula, bem como das medidas que geram informações sobre o padrão do perfil mole. Tomando por base a apostila de cefalometria da USP - Bauru, destaca- se como as variações anatômicas na sela túrcica e na sutura frontonasal podem alterar o valor numérico das medidas referentes às arcadas dentárias e bases apicais, podendo conduzir a um diagnóstico equivocado de inclinação e posicionamento dos incisivos em suas respectivas bases ósseas, bem como a possibilidade das variações anatômicas na sutura frontonasal alterarem o valor numérico da Linha I e do ângulo H.NB, podendo conduzir a conclusões equivocadas.
Tratamento da má oclusão de Classe II de Angle, com mordida aberta anterior e comprometimento periodontal significativo
Authors: Loriato Lívia
Published: September 2019

O tratamento ortodôntico de paciente adulto envolve, muitas vezes, complexidades adicionais, como ausências dentárias e comprometimento periodontal significativo. Nesses casos, recursos de ancoragem esquelética, como implantes dentários e miniplacas, podem ser utilizados para viabilizar o tratamento, minimizando os efeitos indesejados nos dentes remanescentes e favorecendo movimentações dentárias mais complexas. O presente artigo relata o caso clínico de uma paciente adulta com comprometimento periodontal, perdas dentárias, severa mordida aberta anterior e Classe II associada à má postura de língua. O tratamento interdisciplinar envolveu Periodontia, Implantodontia, Ortodontia, Prótese e Fonoaudiologia. O tratamento compensatório realizado utilizando-se recursos de ancoragem esquelética permitiu alcançar resultados estéticos e funcionais satisfatórios, viabilizando a reabilitação e a proservação dos dentes da paciente. Esse caso clínico foi apresentado ao Board Brasileiro de Ortodontia e Ortopedia Facial (BBO) como parte dos requisitos para obtenção do título de Diplomada pelo BBO.