bluuebunny/crossref_metadata_2025 huggingface dataset:
Role of Meteorological Parameters in the Diurnal and Seasonal Variation of NO2 in a Romanian Urban Environment
Authors: Voiculescu Mirela , Constantin Daniel-Eduard , Condurache-Bota Simona , Călmuc Valentina , Roșu Adrian , Dragomir Bălănică Carmelia Mariana
Published: August 2020

The main purpose of this study was to investigate whether meteorological parameters (temperature, relative humidity, direct radiation) play an important role in modifying the NO2 concentration in an urban environment. The diurnal and seasonal variation recorded at a NO2 traffic station was analyzed, based on data collected in situ in a Romanian city, Braila (45.26° N, 27.95° E), during 2009–2014. The NO2 atmospheric content close to the ground had, in general, a summer minimum and a late autumn/winter maximum for most years. Two diurnal peaks were observed, regardless of the season, which were more evident during cold months. Traffic is an important contributor to the NO2 atmospheric pollution during daytime hours. The variability of in situ measurements of NO2 concentration compared relatively well with space-based observations of the NO2 vertical column by the Ozone Monitoring Instrument (OMI) satellite for most of the period under scrutiny. Data for daytime and nighttime (when the traffic is reduced) were analyzed separately, in the attempt to isolate meteorological effects. Meteorological parameters are not fully independent and we used partial correlation analysis to check whether the relationships with one parameter may be induced by another. The correlation between NO2 and temperature was not coherent. Relative humidity and solar radiation seemed to play a role in shaping the NO2 concentration, regardless of the time of day, and these relationships were only partially interconnected.
Mineralogical and Geochemical Nature of Calcareous Vineyard Soils from Alcubillas (La Mancha, Central Spain)
Authors: Jiménez-Ballesta Raimundo , Bravo Sandra , Amorós Jose A. , Pérez-de los Reyes Caridad , García-Giménez Rosario , Higueras Pablo , García-Navarro Francisco J.
Published: August 2020

The mineralogical and geochemical patterns of calcareous vineyard soils located in Alcubillas (La Mancha, Central Spain) have been evaluated; also their variability has been studied. The information provided by this study supports the assessment of geochemical spatial variability, the origin of these soils, their elements and the factors that control their distribution. The presence of quartz, calcite, feldspar and, in particular, illite and kaolinite is due to their inheritance from surrounding lithologies (and pedological processes), which mostly include limestones, marls and other sedimentary rocks, as well as metasedimentary rocks of Hercynian origin. Furthermore, since the presence and accumulation of certain trace elements in vineyard soils is a relevant global hazard (in particular with respect to wine production quality), the spatial distributions of Ba, Cr, Cu, Pb, Rb, Sr, V and Zr (carried out using geostatistical techniques and geometry-based interpolation methods) were investigated in order to determine the origin of these trace elements. The presence of these elements can be interpreted as being due to geogenic, pedogenic and, in certain cases, anthropic influences. The nature of certain agricultural practices, including the use of fertilizers, phytosanitary products and machinery, could explain the local increases in some trace element contents.
How Personality Relates to Distress in Parents during the Covid-19 Lockdown: The Mediating Role of Child’s Emotional and Behavioral Difficulties and the Moderating Effect of Living with Other People
Authors: Mazza Cristina , Ricci Eleonora , Marchetti Daniela , Fontanesi Lilybeth , Di Giandomenico Serena , Verrocchio Maria Cristina , Roma Paolo
Published: August 2020

Since the initiation of the COVID-19 lockdown, Italian parents have been forced to manage their children at home. The present study aimed at investigating the psychological distress of parents during the lockdown, identifying contributing factors. An online survey was administered to 833 participants from 3 to 15 April 2020. Mediation and moderated mediation models were run to explore the association between parent neuroticism and parent distress, mediated by child hyperactivity–inattention and child emotional symptoms, and the moderating effect of living only with child(ren) on the direct and indirect effects of parent neuroticism on parent distress. For parents living only with child(ren), high levels of psychological distress depended exclusively on their levels of neuroticism. For parents living with at least one other person in addition to child(ren), distress levels were also mediated by child behavioral and emotional difficulties. Motherhood emerged as a significant factor contributing to greater distress. Furthermore, parent psychological distress decreased in line with increased child age. The results confirm that neuroticism is an important risk factor for mental health. Preventive measures should be primarily target multicomponent families with younger children and directed towards parents who are already known to present emotional instability and to parents of children who have received local mental health assistance for behavioral and/or emotional difficulties.
Targeting Chemosensory Ion Channels in Peripheral Swallowing-Related Regions for the Management of Oropharyngeal Dysphagia
Authors: Hossain Mohammad Zakir , Ando Hiroshi , Unno Shumpei , Kitagawa Junichi
Published: August 2020

Oropharyngeal dysphagia, or difficulty in swallowing, is a major health problem that can lead to serious complications, such as pulmonary aspiration, malnutrition, dehydration, and pneumonia. The current clinical management of oropharyngeal dysphagia mainly focuses on compensatory strategies and swallowing exercises/maneuvers; however, studies have suggested their limited effectiveness for recovering swallowing physiology and for promoting neuroplasticity in swallowing-related neuronal networks. Several new and innovative strategies based on neurostimulation in peripheral and cortical swallowing-related regions have been investigated, and appear promising for the management of oropharyngeal dysphagia. The peripheral chemical neurostimulation strategy is one of the innovative strategies, and targets chemosensory ion channels expressed in peripheral swallowing-related regions. A considerable number of animal and human studies, including randomized clinical trials in patients with oropharyngeal dysphagia, have reported improvements in the efficacy, safety, and physiology of swallowing using this strategy. There is also evidence that neuroplasticity is promoted in swallowing-related neuronal networks with this strategy. The targeting of chemosensory ion channels in peripheral swallowing-related regions may therefore be a promising pharmacological treatment strategy for the management of oropharyngeal dysphagia. In this review, we focus on this strategy, including its possible neurophysiological and molecular mechanisms.
Thrombocytosis and Effects of IL-6 Knock-Out in a Colitis-Associated Cancer Model
Authors: Josa Valeria , Ferenczi Szilamer , Szalai Rita , Fuder Eniko , Kuti Daniel , Horvath Krisztina , Hegedus Nikolett , Kovacs Tibor , Bagamery Gergo , Juhasz Balazs , Winkler Zsuzsanna , Veres Daniel S. , Zrubka Zsombor , Mathe Domokos , Baranyai Zsolt
Published: August 2020

There is an increasing number of studies showing that thrombocytosis—accompanying a variety of solid tumors including colorectal cancer (CRC)—is associated with shorter survival and earlier development of metastases. The mechanisms of cancer-associated thrombocytosis are not completely understood yet. The aim of our study was to evaluate the role of IL-6 in tumor development and thrombocytosis in mice with inflammation-induced CRC, using a CRISPR/cas9 IL-6 knockout (KO) strain. Adult male FB/Ant mice (n = 39) were divided into four groups: (1) IL-6 KO controls (n = 5); (2) IL-6 KO CRC model group (n = 18); (3) Wild-type (WT) controls (n = 6); and (4) WT CRC model group (n = 10). CRC model animals in (2) and (4) received azoxymethane (AOM)/dextran sodium sulfate (DSS) treatment to induce inflammation-related CRC. Plasma and liver tissues were obtained to determine platelet counts, IL-6 and thrombopoietin-1 (TPO) levels. In 1 WT and 2 IL-6 KO mice in vivo confocal endomicroscopy and 18F-fluorodeoxyglucose (FDG) PET/MRI examinations were performed to evaluate the inflammatory burden and neoplastic transformation. At the end of the study, tumorous foci could be observed macroscopically in both CRC model groups. Platelet counts were significantly elevated in the WT CRC group compared to the IL-6 KO CRC group. TPO levels moved parallelly with platelet counts. In vivo fluorescent microscopy showed signs of disordered and multi-nuclear crypt morphology with increased mucus production in a WT animal, while regular mucosal structure was prominent in the IL-6 KO animals. The WT animal presented more intense and larger colonic FDG uptake than IL-6 KO animals. Our study confirmed thrombocytosis accompanying inflammation-related CRC and the crucial role of IL-6 in this process. Significantly higher platelet counts were found in the WT CRC group compared to both the control group and the IL-6 KO group. Concomitantly, the tumor burden of WT mice was also greater than that of IL-6 KO mice. Our findings are in line with earlier paraneoplastic IL-6 effect suggestions.
Losing Regulation of the Extracellular Matrix is Strongly Predictive of Unfavorable Prognostic Outcome after Acute Myocardial Infarction
Authors: Sung Pei-Hsun , Lin Kun-Chen , Chai Han-Tan , Chiang John Y. , Shao Pei-Lin , Luo Chi-Wen , Yip Hon-Kan
Published: August 2020

This study tested the hypothesis that MMP-9−/−tPA−/− double knock out (i.e., MTDKO) plays a crucial role in the prognostic outcome after acute myocardial infarction (AMI by ligation of left-coronary-artery) in MTDKO mouse. Animals were categorized into sham-operated controls in MTDKO animals (group 1) and in wild type (B6: group 2), AMI-MTDKO (group 3) and AMI-B6 (group 4) animals. They were euthanized, and the ischemic myocardium was harvested, by day 60 post AMI. The mortality rate was significantly higher in group 3 than in other groups and significantly higher in group 4 than in groups 1/2, but it showed no difference in the latter two groups (all p < 0.01). By day 28, the left-ventricular (LV) ejection fraction displayed an opposite pattern, whereas by day 60, the gross anatomic infarct size displayed an identical pattern of mortality among the four groups (all p < 0.001). The ratio of heart weight to tibial length and the lung injury score exhibited an identical pattern of mortality (p < 0.01). The protein expressions of apoptosis (mitochondrial-Bax/cleaved-caspase3/cleaved-PARP), fibrosis (Smad3/T-GF-ß), oxidative stress (NOX-1/NOX-2/oxidized-protein), inflammation (MMPs2,9/TNF-α/p-NF-κB), heart failure/pressure overload (BNP/ß-MHC) and mitochondrial/DNA damage (cytosolic-cytochrome-C/γ-H2AX) biomarkers displayed identical patterns, whereas the angiogenesis markers (small vessel number/CD31+cells in LV myocardium) displayed opposite patterns of mortality among the groups (all p < 0.0001). The microscopic findings of fibrotic/collagen deposition/infarct areas and inflammatory cell infiltration of LV myocardium were similar to the mortality among the four groups (all p < 0.0001). MTDKO strongly predicted unfavorable prognostic outcome after AMI.
Knockdown of α2,3-Sialyltransferases Impairs Pancreatic Cancer Cell Migration, Invasion and E-selectin-Dependent Adhesion
Authors: Guerrero Pedro Enrique , Miró Laura , Wong Bin S. , Massaguer Anna , Martínez-Bosch Neus , Llorens Rafael de , Navarro Pilar , Konstantopoulos Konstantinos , Llop Esther , Peracaula Rosa
Published: August 2020

Aberrant sialylation is frequently found in pancreatic ductal adenocarcinoma (PDA). α2,3-Sialyltransferases (α2,3-STs) ST3GAL3 and ST3GAL4 are overexpressed in PDA tissues and are responsible for increased biosynthesis of sialyl-Lewis (sLe) antigens, which play an important role in metastasis. This study addresses the effect of α2,3-STs knockdown on the migratory and invasive phenotype of PDA cells, and on E-selectin-dependent adhesion. Characterization of the cell sialome, the α2,3-STs and fucosyltransferases involved in the biosynthesis of sLe antigens, using a panel of human PDA cells showed differences in the levels of sialylated determinants and α2,3-STs expression, reflecting their phenotypic heterogeneity. Knockdown of ST3GAL3 and ST3GAL4 in BxPC-3 and Capan-1 cells, which expressed moderate to high levels of sLe antigens and α2,3-STs, led to a significant reduction in sLex and in most cases in sLea, with slight increases in the α2,6-sialic acid content. Moreover, ST3GAL3 and ST3GAL4 downregulation resulted in a significant decrease in cell migration and invasion. Binding and rolling to E-selectin, which represent key steps in metastasis, were also markedly impaired in the α2,3-STs knockdown cells. Our results indicate that inhibition of ST3GAL3 and ST3GAL4 may be a novel strategy to block PDA metastasis, which is one of the reasons for its dismal prognosis.
Pemafibrate Protects Against Retinal Dysfunction in a Murine Model of Diabetic Retinopathy
Authors: Tomita Yohei , Lee Deokho , Miwa Yukihiro , Jiang Xiaoyan , Ohta Masayuki , Tsubota Kazuo , Kurihara Toshihide
Published: August 2020

Diabetic retinopathy (DR) is one of the leading causes of blindness globally. Retinal neuronal abnormalities occur in the early stage in DR. Therefore, maintaining retinal neuronal activity in DR may prevent vision loss. Previously, pemafibrate, a novel selective peroxisome proliferator-activated receptor alpha modulator, was suggested as a promising drug in hypertriglyceridemia. However, the role of pemafibrate remains obscure in DR. Therefore, we aimed to unravel systemic and retinal changes by pemafibrate in diabetes. Adult mice were intraperitoneally injected with streptozotocin (STZ) to induce diabetes. After STZ injection, diet supplemented with pemafibrate was given to STZ-induced diabetic mice for 12 weeks. During the experiment period, body weight and blood glucose levels were examined. Electroretinography was performed to check the retinal neural function. After sacrifice, the retina, liver, and blood samples were subjected to molecular analyses. We found pemafibrate mildly improved blood glucose level as well as lipid metabolism, boosted liver function, increased serum fibroblast growth factor21 level, restored retinal functional deficits, and increased retinal synaptophysin protein expression in STZ-induced diabetic mice. Our present data suggest a promising pemafibrate therapy for the prevention of early DR by improving systemic metabolism and protecting retinal function.
Δ9-Tetrahydrocannabinol Prevents Mortality from Acute Respiratory Distress Syndrome through the Induction of Apoptosis in Immune Cells, Leading to Cytokine Storm Suppression
Authors: Mohammed Amira , F.K. Alghetaa Hasan , Miranda Kathryn , Wilson Kiesha , P. Singh Narendra , Cai Guoshuai , Putluri Nagireddy , Nagarkatti Prakash , Nagarkatti Mitzi
Published: August 2020

Acute Respiratory Distress Syndrome (ARDS) causes up to 40% mortality in humans and is difficult to treat. ARDS is also one of the major triggers of mortality associated with coronavirus-induced disease (COVID-19). We used a mouse model of ARDS induced by Staphylococcal enterotoxin B (SEB), which triggers 100% mortality, to investigate the mechanisms through which Δ9-tetrahydrocannabinol (THC) attenuates ARDS. SEB was used to trigger ARDS in C3H mice. These mice were treated with THC and analyzed for survival, ARDS, cytokine storm, and metabolome. Additionally, cells isolated from the lungs were used to perform single-cell RNA sequencing and transcriptome analysis. A database analysis of human COVID-19 patients was also performed to compare the signaling pathways with SEB-mediated ARDS. The treatment of SEB-mediated ARDS mice with THC led to a 100% survival, decreased lung inflammation, and the suppression of cytokine storm. This was associated with immune cell apoptosis involving the mitochondrial pathway, as suggested by single-cell RNA sequencing. A transcriptomic analysis of immune cells from the lungs revealed an increase in mitochondrial respiratory chain enzymes following THC treatment. In addition, metabolomic analysis revealed elevated serum concentrations of amino acids, lysine, n-acetyl methionine, carnitine, and propionyl L-carnitine in THC-treated mice. THC caused the downregulation of miR-185, which correlated with an increase in the pro-apoptotic gene targets. Interestingly, the gene expression datasets from the bronchoalveolar lavage fluid (BALF) of human COVID-19 patients showed some similarities between cytokine and apoptotic genes with SEB-induced ARDS. Collectively, this study suggests that the activation of cannabinoid receptors may serve as a therapeutic modality to treat ARDS associated with COVID-19.
Attractiveness and Specificity of Different Polyethylene Blue Screens on Stomoxys calcitrans (Diptera: Muscidae)
Authors: Sharif Shukri , Liénard Emmanuel , Duvallet Gérard , Etienne Lucas , Mongellaz Clément , Grisez Christelle , Franc Michel , Bouhsira Emilie , Jacquiet Philippe
Published: August 2020

Stomoxys calcitrans is considered as a major pest of livestock worldwide. Insecticides have been extensively used to control this pest but resistance to these chemical compounds is now reported in many countries. Therefore, a more sustainable and efficient control is needed. Seven different types of blue screens, with reflectances around 460 nm, were tested during summer 2016 in southwestern France to evaluate their attractiveness and their specificity for stable flies. Height of the screen and orientation (east or west) of a blue screen were also considered. High levels of S. calcitrans captures were recorded during this study (from 141 to 7301 individuals per blue screen and per day) whereas the numbers of tabanids and pollinator insects remained extremely low (less than 10 individuals per screen and per day). No significant difference in attractiveness has been shown between the different types of blue screens. The lower half of the blue screens caught significantly more stable flies (70%) than the higher half (30%). The “east” side of the screen attracted 60% of stable flies but this was not significantly different from the west side. These results are highlighting the interest in these blue polyethylene screens for controlling stable flies in cattle farms, in comparison with more expensive blue fabrics.
A Model to Predict the Expansion of Trioza erytreae throughout the Iberian Peninsula Using a Pest Risk Analysis Approach
Authors: Benhadi-Marín Jacinto , Fereres Alberto , Pereira José Alberto
Published: August 2020

Assessing the potential of spread of an introduced crop pest in a new country is crucial to anticipating its effects on crop production and deriving phytosanitary management toward reducing potential negative effects. Citrus production represents a key agricultural activity throughout the Mediterranean basin. The African citrus psyllid Trioza erytreae (del Guercio, 1918) (Hemiptera: Triozidae) is a natural vector of Candidatusliberibacter spp., the causal agent of the harmful disease huanglongbing (HLB) or “citrus greening disease”. In continental Europe, T. erytreae was detected for the first time in northwestern Spain in 2014. Pest risk analysis (PRA) approaches, such as modeling, consider both time and space components to predict the potential distribution of pests in a given region. In this work, we aim to parameterize a model able to predict the expected spread of T. erytreae in the Iberian Peninsula using three types of PRA models. The kernel model with two hypothetical entry points accurately predicted the distribution of T. erytreae with respect to latitude. This model should be further refined and validated to support decision-makers in the adoption of timely and successful management and regulatory measures against the spread of T. erytreae to other citrus-producing areas in Europe.
Is There a Link Between Nutrition, Genetics, and Cardiovascular Disease?
Authors: Ghoch Marwan El , Shamieh Said El
Published: August 2020

Cardiovascular diseases (CVDs) are a group of disorders that mainly include coronary, cerebrovascular and rheumatic heart diseases [...]
Evaluation of Aerobic Exercise Intensity in Patients with Coronary Artery Disease and Type 2 Diabetes Mellitus
Authors: Schwaab Bernhard , Windmöller Mirca , König Inke R. , Schütt Morten
Published: August 2020

(1) Background: Physical activity is recommended in patients with type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD) to reduce hyperglycemia and cardiovascular risk. Effective aerobic exercise intensity, however, is not well defined. (2) Methods: 60 consecutive patients performed cardiopulmonary exercise testing (CPX) of 30 min duration targeting a respiratory exchange ratio (RER) between 0.85 and 0.95, being strictly aerobic. Plasma glucose (PG) was measured before and after CPX as well as one and two h after exercise. Maximum exercise intensity was evaluated using a standard bicycle exercise test. (3) Results: 50 patients completed the protocol (62 ± 10 years, BMI (body mass index) 30.5 ± 4.9 kg/m2, HbA1c (glycated haemoglobin) 6.9 ± 0.8%, left ventricular ejection fraction 55 ± 8%). Aerobic exercise capacity averaged at 32 ± 21 Watt (range 4–76 Watt) representing 29.8% of the maximum exercise intensity reached. PG before and after CPX was 9.3 ± 2.2 and 7.6 ± 1.7 mmol/L, respectively (p < 0.0001). PG was further decreased significantly at one and two h after exercise to 7.5 ± 1.6 mmol/L and 6.0 ± 1.0 mmol/L, respectively (p < 0.0001 for both as compared to PG before CPX). (4) Conclusions: Aerobic exercise capacity is very low in patients with CAD and T2DM. Exercise at aerobic intensity allowed for significant reduction of plasma glucose. Individual and effective aerobic exercise prescription is possible by CPX.
Efficacy of Plasma-Polymerized Allylamine Coating of Zirconia after Five Years
Authors: Rohr Nadja , Fricke Katja , Bergemann Claudia , Nebe J Barbara , Fischer Jens
Published: August 2020

Plasma-polymerized allylamine (PPAAm) coatings of titanium enhance the cell behavior of osteoblasts. The purpose of the present study was to evaluate a PPAAm nanolayer on zirconia after a storage period of 5 years. Zirconia specimens were directly coated with PPAAm (ZA0) or stored in aseptic packages at room temperature for 5 years (ZA5). Uncoated zirconia specimens (Zmt) and the micro-structured endosseous surface of a zirconia implant (Z14) served as controls. The elemental compositions of the PPAAm coatings were characterized and the viability, spreading and gene expression of human osteoblastic cells (MG-63) were assessed. The presence of amino groups in the PPAAm layer was significantly decreased after 5 years due to oxidation processes. Cell viability after 24 h was significantly higher on uncoated specimens (Zmt) than on all other surfaces. Cell spreading after 20 min was significantly higher for Zmt = ZA0 > ZA5 > Z14, while, after 24 h, spreading also varied significantly between Zmt > ZA0 > ZA5 > Z14. The expression of the mRNA differentiation markers collagen I and osteocalcin was upregulated on untreated surfaces Z14 and Zmt when compared to the PPAAm specimens. Due to the high biocompatibility of zirconia itself, a PPAAm coating may not additionally improve cell behavior.
Efficacy of Incremental Next-Generation ALK Inhibitor Treatment in Oncogene-Addicted, ALK-Positive, TP53-Mutant NSCLC
Authors: Urbán László , Dóczi Róbert , Vodicska Barbara , Kormos Dóra , Tóth László , Takács István , Várkondi Edit , Tihanyi Dóra , Lakatos Dóra , Dirner Anna , Vályi-Nagy István , Peták István
Published: August 2020

Background: The anaplastic lymphoma kinase (ALK) gene fusion rearrangement is a potent oncogene, accounting for 2–7% of lung adenocarcinomas, with higher incidence (17–20%) in non-smokers. ALK-positive tumors are sensitive to ALK tyrosine kinase inhibitors (TKIs), thus ALK-positive non-small-cell lung cancer (NSCLC) is currently spearheading precision medicine in thoracic oncology, with three generations of approved ALK inhibitors in clinical practice. However, these treatments are eventually met with resistance. At the molecular level, ALK-positive NSCLC is of the lowest tumor mutational burden, which possibly accounts for the high initial response to TKIs. Nevertheless, TP53 co-mutations are relatively frequent and are associated with adverse outcome of crizotinib treatment, whereas utility of next-generation ALK inhibitors in TP53-mutant tumors is still unknown. Methods: We report the case of an ALK-positive, TP53-mutant NSCLC patient with about five years survival on ALK TKIs with continued next-generation regimens upon progression. Results: The tumor showed progression on crizotinib, but long tumor control was achieved following the incremental administration of next-generation ALK inhibitors, despite lack of evident resistance mechanisms. Conclusion: TP53 status should be taken into consideration when selecting ALK-inhibitor treatment for personalized therapies. In TP53-mutant tumors, switching TKI generations may overcome treatment exhaustion even in the absence of ALK-dependent resistance mechanisms.
Pharmacogenomics to Predict Tumor Therapy Response: A Focus on ATP-Binding Cassette Transporters and Cytochromes P450
Authors: Hlaváč Viktor , Holý Petr , Souček Pavel
Published: August 2020

Pharmacogenomics is an evolving tool of precision medicine. Recently, due to the introduction of next-generation sequencing and projects generating “Big Data”, a plethora of new genetic variants in pharmacogenes have been discovered. Cancer resistance is a major complication often preventing successful anticancer treatments. Pharmacogenomics of both somatic mutations in tumor cells and germline variants may help optimize targeted treatments and improve the response to conventional oncological therapy. In addition, integrative approaches combining copy number variations and long noncoding RNA profiling with germline and somatic variations seem to be a promising approach as well. In pharmacology, expression and enzyme activity are traditionally the more studied aspects of ATP-binding cassette transporters and cytochromes P450. In this review, we briefly introduce the field of pharmacogenomics and the advancements driven by next-generation sequencing and outline the possible roles of genetic variation in the two large pharmacogene superfamilies. Although the evidence needs further substantiation, somatic and copy number variants as well as rare variants and common polymorphisms in these genes could all affect response to cancer therapy. Regulation by long noncoding RNAs has also been shown to play a role. However, in all these areas, more comprehensive studies on larger sets of patients are needed.
The Economic Accessibility of CO2 Sequestration through Bioenergy with Carbon Capture and Storage (BECCS) in the US
Authors: Langholtz Matthew , Busch Ingrid , Kasturi Abishek , Hilliard Michael R. , McFarlane Joanna , Tsouris Costas , Mukherjee Srijib , Omitaomu Olufemi A. , Kotikot Susan M. , Allen-Dumas Melissa R. , DeRolph Christopher R. , Davis Maggie R. , Parish Esther S.
Published: August 2020

Bioenergy with carbon capture and storage (BECCS) is one strategy to remove CO2 from the atmosphere. To assess the potential scale and cost of CO2 sequestration from BECCS in the US, this analysis models carbon sequestration net of supply chain emissions and costs of biomass production, delivery, power generation, and CO2 capture and sequestration in saline formations. The analysis includes two biomass supply scenarios (near-term and long-term), two biomass logistics scenarios (conventional and pelletized), and two generation technologies (pulverized combustion and integrated gasification combined cycle). Results show marginal cost per tonne CO2 (accounting for costs of electricity and CO2 emissions of reference power generation scenarios) as a function of CO2 sequestered (simulating capture of up to 90% of total CO2 sequestration potential) and associated spatial distribution of resources and generation locations for the array of scenario options. Under a near-term scenario using up to 206 million tonnes per year of biomass, up to 181 million tonnes CO2 can be sequestered annually at scenario-average costs ranging from $62 to $137 per tonne CO2; under a long-term scenario using up to 740 million tonnes per year of biomass, up to 737 million tonnes CO2 can be sequestered annually at scenario-average costs ranging from $42 to $92 per tonne CO2. These estimates of CO2 sequestration potential may be reduced if future competing demand reduces resource availability or may be increased if displaced emissions from conventional power sources are included. Results suggest there are large-scale opportunities to implement BECCS at moderate cost in the US, particularly in the Midwest, Plains States, and Texas.
A Dynamic Multi-Period, Mixed-Integer Linear Programming Model for Cost Minimization of a Three-Echelon, Multi-Site and Multi-Product Construction Supply Chain
Authors: Koutsokosta Aspasia , Katsavounis Stefanos
Published: August 2020

Quantifying the benefits of construction supply chain management through prescriptive models is a challenging and fast-growing research area that still lacks standardized optimization models with full integrative potential. In response to the needs and the peculiarities of the construction industry, this paper proposes an innovative model that merges temporal and project-based supply chains into a sustainable network with repetitive flows, large scope contracts, strategic alliances and economies of scale. It is a dynamic mixed-integer linear programming model for cost minimization of a three-echelon supply chain serving multiple sites with multiple products over a time horizon. Its novelty lies in yielding optimal decisions on network design, product quantities to be purchased and transported, shipments and inventory levels in all echelons under any logistics system in a multi-period, multi-product and multi-project environment with discount schemes and strategic preferences. The model is general enough to be implemented by any general contractor acting as a system integrator but also allows customization with logical constraints. All these features constitute an innovative, versatile and flexible managerial decision making tool. Model implementation is based on a spreadsheet optimization software and is followed by post-solution analysis, sensitivity analysis and multiple parameterized optimizations.
Copper Oxides on a Cu Sheet Substrate Made by Laser Technique
Authors: Musztyfaga-Staszuk Małgorzata , Janicki Damian , Gawlińska-Nęcek Katarzyna , Socha Robert , Putynkowski Grzegorz , Panek Piotr
Published: August 2020

This paper presents results from the production of copper oxide layers on a Cu sheet substrate using diode and Yb:YAG disc lasers operating in the wavelength ranges of 808–940 nm and 1030 nm. The parameters of these layers were compared with the layer obtained in the thermal process of copper oxidation at 300 °C in an infrared (IR) furnace in a natural atmosphere. Investigations into the layers mentioned above, concerning their topography, chemical composition and roughness, were made using scanning electron microscopy (SEM) and atomic force microscopy (AFM). A hot-point probe was used to determine and check the type of conductivity of the copper oxide layers formed. The optical band gap energy was estimated by applying the Kubelka–Munk method based on spectrophotometric data. Cross-sections and the element distribution maps were made using transmission electron microscopy (TEM). The phase analysis was investigated by the X-ray diffraction method (XRD). In sum, controlled laser oxidations of copper sheets allow for the formation of a mixture of Cu2O and CuO phases. The diode laser allows the production of a layer of copper oxides with a phase composition comparable to the oxides produced by the thermal oxidation method, while the distribution of high phase uniformity in the cross-section of the layer enables the process using a Yb:YAG disc laser.
Experimental Investigation on the Mechanical Properties and Microstructure of Basalt Fiber Reinforced Engineered Cementitious Composite
Authors: Du Qiang , Cai Changlu , Lv Jing , Wu Jiao , Pan Ting , Zhou Jie
Published: August 2020

This study investigated fundamental mechanical properties of a basalt fiber reinforced engineered cementitious composite (BF-ECC) with different volume fractions of basalt fiber (BF), water–binder ratio (W/B) and fly ash (FA) content. The compressive strength, splitting tensile strength, flexural strength and static modulus of BF-ECC were studied at 3, 28 and 56 days, respectively, to explore their development along the ages. Furthermore, the scanning electron microscopy (SEM) analysis was conducted to evaluate the microstructure of BF-ECC. Experiment results demonstrated that bond quality between the BF and the matrix is good, which leads to a significant increase in the flexural strength and splitting tensile strength. The pozzolanic effect of FA obviously improved the splitting tensile and flexural strength of BF-ECC after 56 days of curing, and the appropriate content of the FA content in the BF-ECC ranges from 50% to 60%.
One-Pot Synthesis and High Electrochemical Performance of CuS/Cu1.8S Nanocomposites as Anodes for Lithium-Ion Batteries
Authors: Wang Lin-Hui , Dai Yan-Kun , Qin Yu-Feng , Chen Jun , Zhou En-Long , Li Qiang , Wang Kai
Published: August 2020

CuS and Cu1.8S have been investigated respectively as anodes of lithium-ion batteries because of their abundant resources, no environment pollution, good electrical conductivity, and a stable discharge voltage plateau. In this work, CuS/Cu1.8S nanocomposites were firstly prepared simultaneously by the one-pot synthesis method at a relatively higher reaction temperature 200 °C. The CuS/Cu1.8S nanocomposites anodes exhibited a high initial discharge capacity, an excellent reversible rate capability, and remarkable cycle stability at a high current density, which could be due to the nano-size of the CuS/Cu1.8S nanocomposites and the assistance of Cu1.8S. The high electrochemical performance of the CuS/Cu1.8S nanocomposites indicated that the CuxS nanomaterials will be a potential lithium-ion battery anode.
Hydrogen Production through Glycerol Photoreforming on TiO2/Mesoporous Carbon: Influence of the Synthetic Method
Authors: Escamilla Juan Carlos , Hidalgo-Carrillo Jesús , Martín-Gómez Juan , Estévez-Toledano Rafael C. , Montes Vicente , Cosano Daniel , Urbano Francisco J. , Marinas Alberto
Published: August 2020

This article explores the effect of the synthetic method of titanium dioxide (TiO2)/C composites (physical mixture and the water-assisted/unassisted sol-gel method) on their photocatalytic activity for hydrogen production through glycerol photoreforming. The article demonstrates that, apart from a high surface area of carbon and the previous activation of its surface to favor titania incorporation, the appropriate control of titania formation is crucial. In this sense, even though the amount of incorporated titania was limited by the saturation of carbon surface groups (in our case, ca. 10 wt.% TiO2), the sol-gel process without water addition seemed to be the best method, ensuring the formation of small homogeneously-distributed anatase crystals on mesoporous carbon. In this way, a ca. 110-fold increase in catalyst activity compared to Evonik P25 (expressed as hydrogen micromole per grams of titania) was achieved.
The Evolution of Residual Stress in Rib-Diaphragm Joints of Orthotropic Steel Decks Subjected to Thermal Cutting and Welding
Authors: Xiong Yongming , Li Chuanxi , Chen Zhuoyi , He Jun , Xin Haohui
Published: August 2020

Residual stresses change the stress ratio of fluctuating stresses, hence seriously affect the fatigue life of orthotropic steel decks (OSDs) under traffic loading. Residual stress distributions near the U rib-diaphragm joints are very complicated and need to be investigated further. In this paper, a systematic method has been proposed for calculating the residual stress field in the joint of U rib and diaphragm due to thermal cutting and welding. Firstly, a mathematical model of cutting heat sources was established to predict the temperature field. Then, a numerical elastoplastic thermomechanical model was built to predict the residual stress evolutions in a diaphragm-rib joint through the whole fabrication process involving flame cutting and welding. Moreover, the simulated temperature contours at the fusion zone and the residual stress distributions in the rib-diaphragm joint were compared and verified against the experimental ones. The numerical results showed a great agreement with the experimental ones, indicating that the heat source model can be used to accurately predict the temperature field during flame cutting. Finally, the validated numerical model was utilized to conduct parametrical analyses on the effects of thermal processing rates, e.g., the cutting and welding speeds and on the residual stress distribution in the rib-diaphragm joint. The results indicate that a faster cutting speed and a slower welding speed can decrease the residual stress magnitude at the rib-diaphragm joints and reduce the high-stress zone near the diaphragm cutouts.
Comparison of Different Heat Treatment Processes of Selective Laser Melted 316L Steel Based on Analysis of Mechanical Properties
Authors: Kluczyński Janusz , Śnieżek Lucjan , Grzelak Krzysztof , Oziębło Artur , Perkowski Krzysztof , Torzewski Janusz , Szachogłuchowicz Ireneusz , Gocman Krzysztof , Wachowski Marcin , Kania Bogusz
Published: August 2020

In this study, we analyzed the mechanical properties of selectively laser melted (SLM) steel obtained via different modifications during and after the manufacturing process. The aim was to determine the effects of precipitation heat treatment on the mechanical properties of elements additively manufactured using three different process parameters. Some samples were additionally obtained using hot isostatic pressing (HIP), while some were treated using two different types of heat treatment and a combination of those two processes. From each manufactured sample, a part of the material was taken for structural analysis including residual stress analysis and microstructural investigations. In the second part of the research, the mechanical properties were studied to define the scleronomic hardness of the samples. Finally, tensile tests were conducted using a digital image correlation (DIC) test and fracture analysis. The treated samples were found to be significantly elongated, thus indicating the advantages of using precipitation heat treatment. Additionally, precipitation heat treatment was found to increase the porosity of samples, which was the opposite compared to HIP-treated samples.
Synthesis of Novel Kaolin-Supported g-C3N4/CeO2 Composites with Enhanced Photocatalytic Removal of Ciprofloxacin
Authors: Huang Zhiquan , Li Leicheng , Li Zhiping , Li Huan , Wu Jiaqi
Published: August 2020

Herein, novel ternary kaolin/CeO2/g-C3N4 composite was prepared by sol-gel method followed by hydrothermal treatment. The self-assembled 3D “sandwich” structure consisting of kaolin, CeO2 and g-C3N4 nanosheets, was systematically characterized by appropriate techniques to assess its physicochemical properties. In the prerequisite of visible-light irradiation, the removal efficiency of ciprofloxacin (CIP) over the kaolin/CeO2/g-C3N4 composite was about 90% within 150 min, 2-folds higher than those of pristine CeO2 and g-C3N4. The enhanced photocatalytic activity was attributed to the improved photo-induced charge separation efficiency and the large specific surface area, which was determined by electrochemical measurements and N2 physisorption methods, respectively. The synergistic effect between the kaolin and CeO2/g-C3N4 heterostructure improved the photocatalytic performance of the final solid. The trapping and electron paramagnetic resonance (EPR) experiments demonstrated that the hole (h+) and superoxide radicals (•O2−) played an important role in the photocatalytic process. The photocatalytic mechanism for CIP degradation was also proposed based on experimental results. The obtained results revealed that the kaolin/CeO2/g-C3N4 composite is a promising solid catalyst for environmental remediation.
Band Gaps and Vibration Isolation of a Three-dimensional Metamaterial with a Star Structure
Authors: Jiang Heng , Zhang Mangong , Liu Yu , Pei Dongliang , Chen Meng , Wang Yuren
Published: August 2020

Elastic metamaterials have promising applications in wave control and vibration isolation, due to their extraordinary characteristics, e.g., negative Poisson ratio, band gaps, effective negative mass density and effective negative modulus. How to develop new functional metamaterials using a special structure has always been a hot topic in this field. In this study, a three-dimensional (3D) star structure is designed to construct metamaterials with both negative static and dynamic properties. The results show that the 3D star structure formed a wide band gap at lower frequency and had a negative Poisson’s ratio. Different from conventional acoustic metamaterials, the main physical mechanism behind the low-frequency band gap of the 3D star structure is the resonance mode formed by the bending deformation of each rib plate, which made it easier to achieve effective isolation of low-frequency elastic waves with a low mass density. In addition, many structural parameters of the 3D star structure can be modulated to effectively adjust the band gap frequency by changing the angle between the concave nodes and aspect ratio. This study provides a new way to design the 3D acoustic metamaterials and develop the lightweight vibration isolation devices.
Octahedron Subgroups and Subrings
Authors: Lee Jeong-Gon , Jun Young Bae , Hur Kul
Published: August 2020

In this paper, we define the notions of i-octahedron groupoid and i-OLI [resp., i-ORI and i-OI], and study some of their properties and give some examples. Also we deal with some properties for the image and the preimage of i-octahedron groupoids [resp., i-OLI, i-ORI and i-OI] under a groupoid homomorphism. Next, we introduce the concepts of i-octahedron subgroup and normal subgroup of a group and investigate some of their properties. In particular, we obtain a characterization of an i-octahedron subgroup of a group. Finally, we define an i-octahedron subring [resp., i-OLI, i-ORI and i-OI] of a ring and find some of their properties. In particular, we obtain two characterizations of i-OLI [resp., i-ORI and i-OI] of a ring and a skew field, respectively.
Granulomatosis with Polyangiitis Restricted to the Back Muscle: The First Case Report
Authors: Lee Yu-Mi , Chung Sang Wan
Published: August 2020

Granulomatosis with polyangiitis (GPA) is an autoimmune disease which is a type of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis that frequently affects the lungs and kidneys. However, GPA limited to a single organ has also been reported. A 71-year-old man was admitted for back pain and fever. We detected elevated levels of inflammatory markers and myeloperoxidase-ANCA. Magnetic resonance imaging indicated diffuse inflammation of the back and psoas muscles. Histology showed degenerated muscle fibers and granulomatosis vasculitis with mixed lymphoplasma cell infiltration. High-dose methylprednisolone therapy improved his symptoms. A final diagnosis of GPA limited to the muscles was made.
Clinical Predictors Influencing the Length of Stay in Emergency Department Patients Presenting with Acute Heart Failure
Authors: Sricharoen Pungkava , Phinyo Phichayut , Patumanond Jayanton , Piyayotai Dilok , Sittichanbuncha Yuwares , Yuksen Chaiyaporn , Likittanasombat Khanchit , Cheuathonghua Ekpaiboon
Published: August 2020

Background and objectives: Acute heart failure is a common problem encountered in the emergency department (ED). More than 80% of the patients with the condition subsequently require lengthy and repeated hospitalization. In a setting with limited in-patient capacity, the patient flow is often obstructed. Appropriate disposition decisions must be made by emergency physicians to deliver effective care and alleviate ED overcrowding. This study aimed to explore clinical predictors influencing the length of stay (LOS) in patients with acute heart failure who present to the ED. Materials and Methods: We conducted prognostic factor research with a retrospective cohort design. Medical records of patients with acute heart failure who presented to the ED of Ramathibodi Hospital from January to December 2015 were assessed for eligibility. Thirteen potential clinical predictors were selected as candidates for statistical modeling based on previous reports. Multivariable Poisson regression was used to estimate the difference in LOS between patients with and without potential predictors. Results: A total of 207 patients were included in the analysis. Most patients were male with a mean age of 74.2 ± 12.5 years. The median LOS was 54.6 h (Interquartile range 17.5, 149.3 h). From the multivariable analysis, four clinical characteristics were identified as independent predictors with an increase in LOS. These were patients with New York Heart Association (NYHA) functional class III/IV (+72.9 h, 95%Confidence interval (CI) 23.9, 121.8, p = 0.004), respiratory rate >24 per minute (+80.7 h, 95%CI 28.0, 133.3, p = 0.003), hemoglobin level <10 mg/dL (+60.4 h, 95%CI 8.6, 112.3, p = 0.022), and serum albumin <3.5 g/dL (+52.8 h, 95%CI 3.6, 102.0, p = 0.035). Conclusions: Poor NYHA functional class, tachypnea, anemia, and hypoalbuminemia are significant clinical predictors of patients with acute heart failure who required longer LOS.
Relationship between Quadriceps Tendon Young’s Modulus and Maximum Knee Flexion Angle in the Swing Phase of Gait in Patients with Severe Knee Osteoarthritis
Authors: Ebihara Bungo , Fukaya Takashi , Mutsuzaki Hirotaka
Published: August 2020

Background and objectives: Decreased knee flexion in the swing phase of gait can be one of the causes of falls in severe knee osteoarthritis (OA). The quadriceps tendon is one of the causes of knee flexion limitation; however, it is unclear whether the stiffness of the quadriceps tendon affects the maximum knee flexion angle in the swing phase. The purpose of this study was to clarify the relationship between quadriceps tendon stiffness and maximum knee flexion angle in the swing phase of gait in patients with severe knee OA. Materials and Methods: This study was conducted from August 2018 to January 2020. Thirty patients with severe knee OA (median age 75.0 (interquartile range 67.5–76.0) years, Kellgren–Lawrence grade: 3 or 4) were evaluated. Quadriceps tendon stiffness was measured using Young’s modulus by ShearWave Elastography. The measurements were taken with the patient in the supine position with the knee bent at 60° in a relaxed state. A three-dimensional motion analysis system measured the maximum knee flexion angle in the swing phase. The measurements were taken at a self-selected gait speed. The motion analysis system also measured gait speed, step length, and cadence. Multiple regression analysis by the stepwise method was performed with maximum knee flexion angle in the swing phase as the dependent variable. Results: Multiple regression analysis identified quadriceps tendon Young’s modulus (standardized partial regression coefficients [β] = −0.410; p = 0.013) and gait speed (β = 0.433; p = 0.009) as independent variables for maximum knee flexion angle in the swing phase (adjusted coefficient of determination = 0.509; p < 0.001). Conclusions: Quadriceps tendon Young’s modulus is a predictor of the maximum knee flexion angle. Clinically, decreasing Young’s modulus may help to increase the maximum knee flexion angle in the swing phase in those with severe knee OA.