bluuebunny/crossref_metadata_2025 huggingface dataset:
MRI noise and auditory health: Can one hundred scans be linked to hearing loss? The case of the Courtois NeuroMod project
Authors: Fortier Eddy , Bellec Pierre , Boyle Julie A. , Fuente Adrian
Published: January 2025

Magnetic resonance imaging (MRI) is one of the most commonly used tools in neuroscience. However, it implies exposure to high noise levels. Exposure to noise can lead to temporary or permanent hearing loss, especially when the exposure is long and/or repeated. Little is known about the hearing risks for people undergoing several MRI examinations, especially in the context of longitudinal studies. The goal of this study was to assess the potential impact of repeated exposure to MRI noise on hearing in research participants undergoing dozens of MRI scans. This investigation was made possible thanks to an unprecedented intensive MRI research data collection effort (the Courtois NeuroMod project) where participants have been scanned weekly (up to twice a week), with the use of hearing protection, since 2018. Their hearing was tested periodically, over a period of 1.5 years. First, baseline pure-tone thresholds and distortion product otoacoustic emission (DPOAE) amplitudes were acquired before the beginning of this study. Hearing tests were then scheduled immediately before/immediately after a scan and with a delay of two to seven days after a scan. Pure-tone thresholds and DPOAE amplitudes showed no scanner noise impact right after the scan session when compared to the values acquired right before the scan session. Pure-tone thresholds and DPOAE amplitudes acquired in the delayed condition and compared to the baseline showed similar results. These results suggest an absence of impact from MRI noise exposure. Overall, our results show that an intensive longitudinal MRI study like the Courtois NeuroMod project likely does not cause hearing damage to participants when they properly utilize adequate hearing protection.
Emotional distress and affective knowledge representation one year after the COVID-19 outbreak
Authors: Barca Laura , Iodice Pierpaolo , Chaigneau Amine , Lancia GianLuca , Pezzulo Giovanni
Published: January 2025

This study examines whether the detrimental effects of the COVID-19 pandemic on the affectivity of the population extend one year after the outbreak. In an online-mobile session, participants completed surveys (i.e., demographic characteristics, positive-negative affectivity, interoceptive awareness) and a similarity judgment task of triplets of emotional concepts, from which we derived 2D maps of their affective knowledge representation. Compared with pre-pandemic data derived from a comparable population, we report three main findings. First, we observed enhanced negative affectivity during the pandemic, but no changes in positive affectivity levels. Second, increased self-reported interoceptive awareness compared to pre-pandemic data, with greater attention to bodily sensations and adaptive aspects of interoceptive sensitivity. Furthermore, female participants reported higher scores than males on the questionnaire subscales of Emotional Awareness and Attention Regulation. Third, the effect of pandemic-related conditions is also apparent in the mental organization of emotional concepts, especially for female participants (i.e., reduced coherence in the organization of the concepts along the arousal dimension and more misclassification of concepts based on arousal) and participants who did not perform physical activity (a collapse of the arousal dimension). Some of the effects of the pandemic, thus, persist about a year after the outbreak. These results advise providing programs of psychological and emotional assistance throughout the pandemic beyond the outbreak, and that age-dependent gender differences should be accounted for to define tailored interventions. Physical activity might relieve pandemic-related stressors, so it should be promoted during particularly stressful periods for the population.
Pooled prevalence and subgroup variations of Tetralogy of Fallot among children and adolescents with congenital heart defect in Sub-Saharan Africa: A systematic review and meta-analysis
Authors: Geleta Biniam Endale , Mulu Abay
Published: January 2025

Background

Tetralogy of Fallot is one of the critical congenital heart defects needing intervention within the first year of life.

Objective

This review aims to systematically assess the prevalence of Tetralogy of Fallot among children and adolescents with congenital heart defects in Sub-Saharan Africa from January 2000 to January 2024.

Methods

All original observational studies focused on children and adolescent population diagnosed with congenital heart defects within Sub-Saharan Africa; reported the primary outcome of interest were included. Prisma guidelines were utilized to perform this systematic review and meta-analysis. Electronic databases including Medline (PubMed), Scopus, Google Scholar, and African Index Medicus were searched. A weighted inverse variance random-effects model was employed to estimate the pooled prevalence of Tetralogy of Fallot.

Results

Thirty-one studies included encompassing a total of 11,265 participants from 15 Sub-Saharan African countries with representation from Southern (4 studies, 619 participants), Central (5 studies, 2,220 participants), Eastern (11 studies, 3,384 participants), and Western (11 studies, 5,042 participants). Cross-sectional studies comprised (25 studies, 8,909 participants), and cohort design (6 studies, 2,356 participants). The analysis revealed a pooled prevalence of 10% (95% CI: 9%; 12%) with I2 (77%, p-value < 0.01). The subgroup analysis based on geographic regions revealed statistically significant difference.

Conclusions and future implications

The prevalence of Tetralogy of Fallot observed was found considerably higher compared to global estimate and reports of developed countries. In a subgroup analysis based on the geographic region, a surprisingly high prevalence was reported across all regions of Sub-Saharan Africa. The substantial disparities and high prevalence observed underscores the complex interplay of factors influencing occurrence of Tetralogy of Fallot. Identifying the true scope of Tetralogy of Fallot burden may help policymakers and healthcare providers to prioritize interventions, optimize resource allocation, and potentially improve its outcomes in Sub-Saharan Africa.
Investigation of the trends and associated factors of ovarian cancer in Indonesia: A systematic analysis of the Global Burden of Disease study 1990–2021
Authors: Tjokroprawiro Brahmana Askandar , Novitasari Khoirunnisa , Ulhaq Renata Alya , Sulistya Hanif Ardiansyah , Martini Santi
Published: January 2025

Introduction

Ovarian cancer is one of the most lethal gynecological cancers. Despite diagnosis and treatment advances, survival rates have not increased over the past 32 years. This study estimated and reported the global burden of ovarian cancer during the past 32 years to inform preventative and control strategies.

Methods

We examined ovarian cancer incidence, mortality, and disability-adjusted life years (DALYs) using age-standardized rates from the Global Burden of Disease, Injuries, and Risk Factors Study 2021. high body mass index and occupational asbestos exposure were linked with death and DALYs. Data are presented as averages with 95% uncertainty intervals (UIs).

Results

Indonesia had 13 250 (8 574–21 565) ovarian cancer cases in 2021, with 5 296 (3 520–8958) deaths and 186 917 (121 866–309 820) DALYs. The burden increased by 233.53% for new cases, 221.95% for mortalities, and 206.65% for DALYs. The age-standardized rate also increased from 1990 to 2021. Ovarian cancer burden increased with age but declined in the 50+ year age group. According to the sociodemographic index, the gross domestic product per capita and number of obstetricians and oncologic gynecologists in provinces showed different trends.

Conclusions

Indonesian ovarian cancer rates are rising despite gynecologic oncologists in 24 of 34 provinces. These findings will help policymakers and healthcare providers identify ovarian cancer prevention and control gaps.
The severity of coronary heart disease and the incidence of later diabetic retinopathy in diabetic population: A retrospective cohort study
Authors: Ting Ke-Hsin , Yang Po-Jen , Huang Jing-Yang , Lee Chia-Yi , Su Shih-Chi , Yang Shun-Fa
Published: January 2025

Objectives

The coronary heart disease (CHD) can influence the development of several diseases. The presence of CHD is correlated to a higher incidence of concurrent diabetic retinopathy (DR) in previous study. Herein, we aim to analyze the relationship between the CHD severity and following DR with different severity.

Methods

A retrospective cohort study was conducted with the usage of Taiwan National Health Insurance Research Database (NHIRD). The CHD patients with DM were categorized into those with medical treatments and those received percutaneous coronary intervention (PCI) management with a 1:1 ratio. The major outcome was the development of DR, diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR) 6 months after the onset of CHD.

Results

There was 7317, 316, and 386 episodes of DR, DME and PDR in the mild CHD groups and 8568, 411, and 508 events of DR, DME and PDR in the severe CHD groups, respectively. The severe CHD group showed a significantly higher incidence of DR (aHR: 1.063, 95% CI: 1.038–1.089, P = 0.0324), DME (aHR: 1.412, 95% CI: 1.252–1.594, P = 0.0092) and PDR (aHR: 1.314, 95% CI: 1.172–1.473, P = 0.0113) compared to the mild CHD group. The cumulative incidence of DR was significantly higher in the severe CHD group (P < 0.001). In the subgroup analysis, the association between CHD severity and DR was more prominent in the female population (P = 0.0224).

Conclusions

The severe CHD is associated with higher incidence of following DR, DME and PDR, while the incidence of DR in CHD is positively correlated to longer disease period.
Automating the amino acid identification in elliptical dichroism spectrometer with Machine Learning
Authors: Balamurugan Ridhanya Sree , Asad Yusuf , Gao Tommy , Nawarathna Dharmakeerthi , Tida Umamaheswara Rao , Sun Dali
Published: January 2025

Amino acid identification is crucial across various scientific disciplines, including biochemistry, pharmaceutical research, and medical diagnostics. However, traditional methods such as mass spectrometry require extensive sample preparation and are time-consuming, complex and costly. Therefore, this study presents a pioneering Machine Learning (ML) approach for automatic amino acid identification by utilizing the unique absorption profiles from an Elliptical Dichroism (ED) spectrometer. Advanced data preprocessing techniques and ML algorithms to learn patterns from the absorption profiles that distinguish different amino acids were investigated to prove the feasibility of this approach. The results show that ML can potentially revolutionize the amino acid analysis and detection paradigm.
Development and laboratory evaluation of a novel IoT-based electric-driven metering system for high precision garlic planter
Authors: Elwakeel Abdallah Elshawadfy , Elbeltagi Ahmed , Dewidar Ahmed Z. , Salem Ali , Abdeen Mohamed Anwer
Published: January 2025

In order to address many issues, such as the inconsistent and unreliable seeding process in traditional mechanical garlic seed metering systems (SMS), as well as the lack of ability to monitor the effectiveness of the seeding, a highly accurate electric-driven metering system (EDMS) was developed and created specifically for garlic seed planters. This study provided a description of the overall structure and functioning principle, as well as an analysis of the mechanism for smooth transit and delivery. A combination of an infrared (IR) sensor, Arduino Mega board, stepper motor, speed sensor, and a Wi-Fi module was employed to operate the EDMS, as well as monitor and count the quantity of garlic seeds during the planting process and determine the qualified rate (QR) and missing rate (MR). A monitoring system of the planting quality of garlic seeds was created based on the IoT concept. Then, the performance of the EDMS was validated in a laboratory setting utilizing a bench test at six operating velocities of 10, 20, 30, 40, 50, and 60 rpm of the EDMS. The obtained results showed that the correlation coefficient between the actual and detected garlic seed using the garlic seed monitoring and counting system (GSMCS) was 0.9723. Additionally, the EDMS observed a maximum QR of 96.23% at an operating velocity of 20 rpm, with a standard division and standard error of 1.61030 and 0.72015, respectively. Additionally, the EDMS minimized the MR up to 3.77% at the same operating velocity, with standard division and standard error of 1.65325 and 0.73936, respectively. Furthermore, the results indicated a progressive increase in the QR and MQ standard errors as the EDMS’s operating velocity increased. Additionally, the sensor’s monitoring accuracy gradually declined with an increase in the operating speed of the EDMS. Finally, this study introduced a novel EDMS to garlic seed planters that was not used before. The developed EDMS and GSMCS are technical manuals for developing and designing monitoring systems capable of precisely measuring and identifying the rates of qualifying and missing garlic seed measurements.
LARP3 inhibits the apoptosis of hepatocellular carcinoma via the ROS/PI3K/c-Fos axis
Authors: Zhu Lin , Meng Qianqian , Qian Weiyi , Shao Weiting , Lu Yuyue , Jin Shuai , Zhang Afei , Yan Shuang G. , Lu Jingtao
Published: January 2025

Primary hepatocellular carcinoma (PHC) is the sixth most common cancer and the third leading cause of cancer death worldwide. Hepatocellular carcinoma (HCC) accounts for 75%-85% of PHC. LARP3 is aberrantly expressed in multiple cancers. We found that it is significantly highly expressed in the liver cancer tissues of HCC patients, but the exact role and specific mechanism of this abnormal expression are not yet clear. In this study, through bioinformatics analysis, we concluded that LARP3 expression is associated with a poor prognosis for patients with HCC. Through cellular experiments such as gene editing and phenotypic functions, we found that LARP3 promotes the occurrence and development of HCC and inhibits apoptosis. Finally, through biological means such as RNA sequencing, flow cytometry, western blotting, and the construction of a subcutaneous tumorigenesis model in nude mice, we concluded that inhibition of HCC apoptosis by LARP3 is related to LARP3 negatively regulating ROS level and inhibiting the PI3K/c-Fos/apoptosis axis. This study will provide potential targets for the treatment of HCC.
Effectiveness of couple-based violence prevention education in reducing intimate partner violence during pregnancy in rural Ethiopia: A cluster randomized controlled trial
Authors: Agde Zeleke Dutamo , Magnus Jeanette H. , Assefa Nega , Wordofa Muluemebet Abera
Published: January 2025

Background

Pregnancy is often seen as a joyful and fulfilling time for many women. However, a significant number of women in Ethiopia experience intimate partner violence (IPV) during this period. Despite this, there is limited evidence on interventions aimed at preventing violence during pregnancy. The purpose of this trial was to examine the effectiveness of Couple-Based Violence Prevention Education (CBVPE) in reducing IPV during pregnancy in rural Ethiopia.

Method

A cluster randomized controlled trial was conducted using a two-arm parallel group design. The 16 clusters were randomly allocated into 8 intervention groups and 8 control groups. A total of 432 pregnant women (216 in the intervention group and 216 in the control group) participated in the trial. Couple-based violence prevention education was provided to the participants in the intervention group, while the control group received routine or standard care. We used difference-in-difference analysis and the Generalized Estimating Equation (GEE) model to assess the effectiveness of the intervention.

Result

At the endline, 94.9% of women in the intervention group and 95.3% of women in the control group were available for intention-to-treat analysis. There was a substantial drop in the proportion of any IPV during pregnancy from 39.4% at baseline to 13.0% at endline (p<0.001). Women in the intervention group were 74.1% less likely to report any IPV during pregnancy compared to the control group (AOR = 0.259; 95% CI 0.161–0.417). Specifically, the intervention also reduced psychological, physical, and sexual violence during pregnancy.

Conclusion

The study found that CBVPE is effective in reducing IPV during pregnancy in the study setting. Scale-up and adaptation to similar settings are recommended.

Trial registration

The trial is registered on ClinicalTrials.gov under the identifier NCT05856214 on May 4, 2023.
The effects of lowering barometric pressure on pain behavior and the stress hormone in mice with neuropathic pain
Authors: Terajima Yuki , Sato Jun , Inagaki Hideaki , Ushida Takahiro
Published: January 2025

Background

Lowering barometric pressure (LP) can exacerbate neuropathic pain. However, animal studies in this field are limited to a few conditions. Furthermore, although sympathetic involvement has been reported as a possible mechanism, whether the sympathetic nervous system is involved in the hypothalamic-pituitary-adrenal (HPA) axis remains unknown. To address these issues, we investigated LP-induced hyperalgesia by focusing on the cumulative effect of LP and measuring plasma corticosterone levels as a marker of HPA axis activation in mice.

Methods

Mice with chronic constriction injury (CCI) were used in this study. For behavioral tests, two types of LP stimulation were adopted: a single LP at 20 hPa (Single LP) and three consecutive LPs at 20 hPa (3LPs). Twelve mice were used for each protocol. The no-pressure-change protocol was used as the control. The mechanical sensitivity was tested before and after LP stimulation using von Frey filaments (vF). For corticosterone measurements, six CCI and six intact mice were exposed to 3LPs (CCI-3LPs and INT-3LPs), and another six CCI and six intact mice were exposed to the no-pressure-change protocol (CCI-NP and INT-NP). Blood samples were collected immediately after exposure. Plasma corticosterone levels were measured by ELISA.

Results

The number of paw elevations by vF before and after LP stimulation did not differ significantly in either the Single LP or the no-pressure-change protocol. For the 3LPs, the number of paw elevations after LP stimulation was significantly greater than before stimulation. Plasma corticosterone levels in the CCI-3LPs were significantly higher than those in CCI-NPs. In intact mice, there was no significant difference in plasma corticosterone levels between the INT-3LPs and INT-NPs.

Conclusions

LP has a cumulative effect on neuropathic pain. Hypothalamic-pituitary-adrenal axis activation may have an important relationship with LP-induced pain in mice.
Deficient neutrophil responses early in influenza infection promote viral replication and pulmonary inflammation
Authors: Gong Henry H. , Worley Matthew J. , Carver Kyle A. , Godin Caleb J. , Deng Jane C.
Published: January 2025

Neutrophils play key protective roles in influenza infections, yet excessive neutrophilic inflammation is a hallmark of acute lung injury during severe infections. Phenotypic heterogeneity is increasingly recognized in neutrophil populations; however, how functional variation in neutrophils between individuals determine the diverse outcomes of influenza remains unclear. To examine immunologic responses that may drive varying outcomes in influenza, we infected C57BL/6 (B6) and A/J mice with mouse-adapted influenza A virus A/PR/8/34 H1N1. A self-resolving dose in B6 mice was lethal in A/J mice, which had increased viral load throughout infection accompanied by prominent bronchoalveolar neutrophilia and pulmonary vascular leakage preceding mortality. Notably, the B6 mice heavily recruited neutrophils to lungs early in infection while A/J mice failed to do so. Neutrophils from A/J mice additionally displayed reduced neutrophil extracellular trap (NET) release and reactive oxygen species (ROS) generation compared to B6 mice early in infection, suggesting the failure to control virus in A/J mice was a product of deficient neutrophil response. To determine if variation in neutrophils between strains governed viral control and inflammation, we adoptively transferred bone marrow neutrophils from B6 or A/J donors to A/J recipients early in infection and found that the transfer of B6 neutrophils enhanced viral clearance and abrogated the dissemination of CXCL1 and IL-6. The transfer of A/J neutrophils, however, failed to achieve either. Furthermore, B6 neutrophils were capable of greater levels of viral killing in vitro than their A/J counterparts. These results suggest that a key moderator of inflammation in influenza infection is the control of virus by neutrophils early in infection. Thus, host-specific differences in both the recruitment of these cells as well as interindividual variation in neutrophil ability to support viral clearance may in part dictate differing susceptibility to respiratory viral infections.
The uncanny valley in the music classroom: Perspectives on overcorrection
Authors: Coles Drew X. , Zane Cato
Published: January 2025

This article explores the uncanny valley in music and how it relates to music technology and music education today. The uncanny valley arises when human observers perceive something as close to human but not quite human. As human observers, our potentially positive perception of something shifts into the negative as it gets very close to being realistically human without hitting the mark. In this article, we cite recent technological advances that enable musical output that may fall into the uncanny valley. We explore how technology today allows for music creation that eliminates human nuance from a composition when parameters like rhythm, tempo and pitch have been heavily processed by computers. As educators and music creators, it is important to acknowledge this fact so that we can better educate ourselves on how to avoid or utilize this musical uncanny valley as desired. This article not only explores the musical uncanny valley as one reason why educators must dig into music technology past the surface level, but it also explores our responsibility to music students. Music teachers today have a responsibility to learn and teach the finer details of using music tech tools in the classroom, so that future music creators have the ability to preserve human nuance in their musical creations.
Grassroot free fight neo-liberalism: Becak motor (bentor) drivers as homo sacer in downtown Yogyakarta, Indonesia
Authors: Nugroho Heru , Sudarwo Fajar , Artosa Odam Asdi
Published: January 2025

This article is an in-depth exploration of the struggle of becak motor (abbreviated as bentor) drivers as homo sacer who must fight hard amidst the wheels of neo-liberalism at the grassroots level. Becak motor is a kind of motorized pedicab commonly found in Indonesia, especially on the island of Java. In the era of the free market, bentor drivers are not only battling over economic resources to get passengers, but they are also fighting against structural barriers where regulations on bentor are left deliberately unclear. The exacerbation of this condition is caused by their uncertainty in obtaining access to proper welfare as citizens. This study employs a qualitative method with a life history approach that specifically explores the journey of life and important events that have shaped the lives of bentor drivers in Yogyakarta. The informants consisted of three categories: first, bentor drivers from urban areas; second, from the countryside (rural); third, bentor drivers who represent becak association administrators. The findings of this study indicate that bentor drivers have to struggle to access economic resources at the grassroots level due to several factors, such as the increasing number of private vehicles leading to a decrease in demand for the use of bentors, increasing competition with online transportation applications; there are structural barriers related to the regulation of bentors which continuously being ignored; and other negative stigma attached to bentors. In facing these challenges, they also have a survival strategy developed from a mutual help mechanism designed within the bentor community. Therefore, this article offers an academic debate on the battle of bentor drivers as a homo sacer in the vortex of neo-liberalism, as well as presents a critical perspective in providing an overview of how neo-liberalism works at the grassroots level.
Sculpture in the City, 2023
Authors: O’Kane Paul
Published: January 2025

This article discusses the unique qualities and experience of attending London’s Sculpture in the City trail. The piece also explores differences between gallery art and public art, as well as notions of transcendence in art. The concept of belief is also discussed as variously illustrated by religious architecture, art or a financial system that gambles on futures and insurances. Ultimately and implicitly, the piece encourages ways to think about our encounters with art in our urban setting, and specifically with public sculpture.
Higher Relapse Rate in HBeAg-Negative Patients After Cessation of Tenofovir Alafenamide Compared With Entecavir or Tenofovir Disoproxil Fumarate
Authors: Fang Hsin-Wei , Jeng Wen-Juei , Hu Tsung-Hui , Wang Jing-Houng , Hung Chao-Hung , Lu Sheng-Nan , Chen Chien-Hung
Published: January 2025

INTRODUCTION:

There is limited information comparing the off-therapy relapse rates of patients discontinued tenofovir alafenamide (TAF) to those stopping entecavir or tenofovir disoproxil fumarate (TDF).

METHODS:

A total of 805 hepatitis B e antigen-negative patients without cirrhosis receiving entecavir (n = 406), TDF (n = 260), or TAF (n = 139) were enrolled. Propensity score matching method was applied to eliminate the significant differences in clinical characteristics.

RESULTS:

The cumulative incidences of virological relapse, clinical relapse, and retreatment at 96 weeks were higher in the off-TAF group (89.6%, 70.3%, and 59.2%, respectively) than that in the off-entecavir group (65.9%, 42.8%, and 28.8%, respectively) or the off-TDF group (73.7%, 49.8%, and 35.7%, respectively). The median time to clinical relapse was much earlier for off-TAF patients than for off-entecavir or off-TDF (median 14, 57, and 26 weeks, respectively), and these findings persisted even after propensity score matching. Multivariate analysis indicated that TAF therapy was an independent risk factor of virological relapse, clinical relapse, and retreatment when compared with entecavir or TDF. Hepatitis B surface antigen levels at end of treatment were predictive of virological, but not clinical, relapse in the off-TAF group, although this group had a lower rate of severe hepatitis on clinical relapse than the off-TDF group. Finally, there was no significant difference in the hepatic decompensation rate among the entecavir, TDF, and TAF groups.

DISCUSSION:

There is an earlier and higher hepatitis B virus relapse rate in patients who discontinue TAF therapy than in comparable patients discontinuing entecavir or TDF therapy. Close monitoring is necessary after TAF withdrawal, particularly in the first 3 months.
Trudinger–Moser type inequalities with logarithmic weights in fractional dimensions
Authors: Xue Jianwei , Zhang Caifeng , Zhu Maochun
Published: January 2025

The purpose of this paper is two-fold. First, we derive sharp Trudinger–Moser inequalities with logarithmic weights in fractional dimensions:

 

sup

∫

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(

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,

$$\,\underset{{\left(\underset{0}{\overset{1}{\int }}w\left(r\right){\left\vert {u}^{\prime }\left(r\right)\right\vert }^{\beta +2}\mathrm{d}{\lambda }_{\alpha }\right)}^{1/\left(\beta +2\right)}\le 1}{\mathrm{sup}}\underset{0}{\overset{1}{\int }}{\text{e}}^{{\mu }_{\alpha ,\theta ,\gamma }{\left\vert u\right\vert }^{\frac{\beta +2}{\left(\beta +1\right)\left(1-\gamma \right)}}}\mathrm{d}{\lambda }_{\theta }{< }+\infty ,$$

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${\mu }_{\alpha ,\theta ,\gamma }{:=}\left(\theta +1\right){\left[{\omega }_{\alpha }^{1/\alpha }\left(1-\gamma \right)\right]}^{\frac{1}{1-\gamma }}$

,

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. The case γ > 1 and γ = 1 are also be considered in this part to improve our paper. Indeed, we have a continuous embedding X(w
2) ↪ L
∞(0, 1) for γ > 1 and a critical growth of double exponential type for γ = 1. Second, we apply the Lions type Concentration-Compactness principle for Trudinger–Moser inequalities and the precise estimate of normalized concentration limit for normalized concentrating sequence at origin to establish the existence of extremals for Trudinger–Moser inequalities when

w

(

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$w\left(r\right)={w}_{1}\left(r\right)={\left(\mathrm{log}\frac{1}{r}\right)}^{\gamma \left(\beta +1\right)}$

and γ > 0 is sufficiently small.
Extraction and characterization of natural fibre from Ethiopian Typha latifolia leaf plant
Authors: Admas Anmen , Assefa Alemayehu
Published: January 2025

The environmental issues associated with synthetic fibres have led to a significant growth in the use of natural fibres (NFs). Because of this environmental issue, the demand for NF is higher as compared to synthetic fibres. The purpose of the present study was to extract and characterize fibres from the Ethiopian Typha latifolia leaf plant. Manual, water-retting, and chemical extraction techniques were employed for the extraction of the fibre from the leaf of the Typha latifolia plant. The extracted fibre’s chemical content was evaluated, and its cellulose, hemicellulose, and lignin contents were almost similar to those of other NFs. The mean length, fineness, and tensile strength of fibre extracted by manual, water retting, and alkaline methods were determined, and its length was 502, 489, and 389 mm, and its fineness was 1.42 ± 0.4 Tex, 1.32 ± 0.2 Tex, and 1.12 ± 0.15 Tex, and its strength was 260.3, 308.5, and 192.8 MPa, respectively. The ranges for moisture content and regain were 8.4–10.8% and 8.7–11.4%, respectively, which is comparable to other natural plant fibres (5–17%). The Fourier transform-infrared curves of the extracted fibre revealed the presence of the functional groups for cellulose, hemicellulose, and lignin.
Priced Out: Do Adolescents from Low-Income Families Respond More to Cost-Sharing in Primary Care?
Authors: Haaga Tapio , Böckerman Petri , Kortelainen Mika , Tukiainen Janne
Published: January 2025

We examine the heterogeneous effects of 14–21 euro copayments on primary care general practitioners (GPs) visits in Finland. Our study focuses on a triage-based appointment system in public primary care. Using an age-based regression discontinuity (RD) design and leveraging variation across Finnish municipalities in whether the copayment is charged, we analyze the effects at the 18th birthday, when previously exempted adolescents become subject to copayments. Using nationwide administrative data from 2011 to 2019, we find that GP visits decrease in the copayment municipalities by 4–5 %. The reductions are largest for the bottom 20 % of the equivalized family disposable income distribution: their GP use decreases by 0.08–0.10 annualized visits (7–10 %). Unexpectedly, the effects are also larger than average (albeit rather temporary) for the top 50 %, showing reductions of 6–8 %. Compared to earlier studies focusing on moderate copayments and different populations, our effect estimates are smaller, and the heterogeneity by income level is weaker.
La metáfora del shoggoth en la inteligencia artificial
Authors: Masís González Tadeo
Published: January 2025

Mediante la metáfora del shoggoth, la comunidad alrededor del desarrollo de los grandes modelos de lenguaje en la inteligencia artificial describe características particulares de esta tecnología. Dadas sus condiciones de opacidad y aparente inconmensurabilidad, estos modelos algorítmicos llaman a cuestionar algunas propiedades epistemológicas de la tecnología y su rol en el proyecto moderno. El presente texto tiene como propósito exponer reflexiones derivadas del uso de esta metáfora en el contexto de la inteligencia artificial, de manera que sea posible señalar paradojas para la sociedad moderna, así como realizar un bosquejo de lo que podrían ser nuevas propiedades de la tecnología.
Non-native and spreading craneflies in Europe: A review, with first and additional records
Authors: Kolcsár Levente-Péter
Published: January 2025

Despite the more than 15.700 known cranefly species, only a few species have been identified or hypothesized as non-native species. However, in recent years, reports of non-native craneflies in Europe have increased significantly. This work provides a comprehensive list of species either confirmed or suspected to be non-native in Europe, as well as native species that have recently appeared in new countries and are expanding their distribution ranges. Additionally, Atypophthalmus umbratus (de Meijere, 1911) has been reported for the first time in Denmark, within greenhouse environments. Gnophomyia tristissima Osten Sacken, 1860 was observed in a natural habitat in Hungary, marking the second European occurrence of this species. Rhipidia (Rhipidia) domestica Osten Sacken, 1860, and Nephrotoma suturalis wulpiana (Bergroth, 1888) were found in Romania, originating from a plant shop. Furthermore, Tipula (Pterelachisus) trifascingulata Theowald, 1980, from Luxembourg, and Nephrotoma quadrifaria quadrifaria (Meigen, 1804), from Northern European Russia, are reported here for the first time. Achyrolimonia neonebulosa (Alexander, 1924), another recently spearing species, was discovered trapped on the leaves of sundews (Drosera spp.) in the same plant shop where R. domestica and N. s. wulpiana were collected in Romania. These findings underscore the likelihood that these species have already become widely dispersed through plant trade across Europe.
Moderate Islamic Influencers in Digital Communication Discourse
Authors: Musta'in Musta'in
Published: January 2025

This research aims to explain the digital communication patterns carried out by religious influencers in transmitting and distributing Islamic values as a representation of moderate Islam, with Habib Ja'far as the central figure. The data used in this qualitative study was gathered by looking at the YouTube login account of a channel that Onadio Leonardo and Habib Ja'far lead. Research data analysis refers to the concept of digital communication developed by Caroline Tagg, which emphasizes flexibility, freedom, and dialogue in digital interactions. The research results show that, first, in the new media era, content uploaded by the login account has become a strategic medium for conveying moderate Islamic values by utilizing an inclusive approach using relaxed, humorous, and engaging language. Second, Habib Ja'far, as a religious influencer, prioritizes the spirit of freedom of communication, namely the expression of religious beliefs that not only respect differences but also avoid blaming or denigrating other beliefs. This approach shows that Islam can be presented as a friendly, tolerant religion relevant to the times' challenges. This research contributes to understanding the role of digital communication in voicing Islamic values of moderation. These findings also offer a new perspective on how digital media can be a strategic space for conveying peaceful and inclusive Islamic narratives.
Effects of silica micropowder on the long-term water stability of magnesium potassium phosphate cement paste
Authors: Li Tao , Huang Feng , Tang Lei , Yang Jianming , Hu Xiamin , Hou Yuying , Li Jun
Published: January 2025

Magnesium potassium phosphate cement (MKPC) are future materials for the corrosion protection of steel-reinforced concrete structures owing to their environmental friendliness, strong adhesion to the substrate and excellent resistance to salt corrosion. In this study, an MKPC coating paste satisfying the design specifications of self-compacting concrete was prepared by increasing the water–cement (w/c) ratio and adding sodium silicate (Na2SiO3) and silica micropowder (SMP) to regulate the fluidity and compatibility. The mechanical strength, deformation, water absorption and long-term water stability were compared for MKPC coating pastes with and without SMP. Replacing magnesium oxide (MgO) powder with 10% SMP could improve the physical and mechanical properties of MKPC paste under long-term water immersion. After 540 days of water immersion, the flexural and compressive strength residuals of the reference MKPC without SMP (0SMP10M) were 84.4% and 74.6%, respectively. In contrast, those of the MKPC with 10% SMP (1SMP9M) were 105.6% and 97.9%, respectively. The volume of 0SMP10M expanded during 540 days of water immersion, and the final volume deformation was 10.1 × 10−4, while the volume expansion of 1SMP9M was 7.46 × 10−4. After 540 days of immersion, the water absorption levels of 0SMP10M and 1SMP9M were 1.45% and 1.17%, respectively.
Redes neuronales artificiales
Authors:   Universidad Cooperativa de Colombia, Guzmán Paredes Yomaira
Published: January 2025

A través de esta guía el estudiante profundizará en conceptos sobre redes neuronales artificiales como algoritmo de inteligencia computacional para la predicción. Esta guía práctica describe cómo aplicar el concepto de una red perceptrón mediante el uso de Python en un ejercicio. Las redes neuronales artificiales son algoritmos bioinspirados en el comportamiento de una neurona biológica, a partir de ellas podemos realizar clasificación. En esta oportunidad está enfocado en un ejercicio enfocado a evaluar la admisión de un estudiante a la Universidad Cooperativa de Colombia. Una vez haya finalizado esta guía el estudiante estará en capacidad de aplicar las redes neuronales para la solución de problemas de clasificación de la vida real.
Adaptación al cambio climático y democracia. El caso de La Paz-Bolivia
Authors: Zuazo Moira
Published: January 2025

A inicios del siglo XXI en un mundo de crecientes incertidumbres, una de las pocas certidumbres que se instala, es la de un futuro desafiado por la realidad del cambio climático como contexto. El cambio climático ha dejado de ser un tema desplazable a los márgenes, para pasar al centro de la agenda política global, un factor que ha contribuido a este salto es que los efectos del cambio climático (CC) cada vez con mayor claridad, se perciben como parte de la vida cotidiana de la gente a lo largo y ancho del planeta.
A TERTÚLIA LITERÁRIA DIALÓGICA NA SALA DE AULA: UM OLHAR CRÍTICO-SOCIAL PARA O TEXTO
Authors: Lima Luiz Carlos Cordeiro , Lima Fabiana Carla Lopes de , Santos Gracilmara Quixaba dos , Bernardes Raiany de Castro Souza , Medrado Kátia Simone Mendonça Pionório , Santos Maria Celma Vieira , Sena Susana Wesley da Silva
Published: January 2025

O presente artigo tem como objetivo relatar os resultados de uma experiência de ensino-aprendizagem de leitura, na Educação Básica, na Escola de Referência em Ensino Médio Padre Manoel de Paiva Netto, localizada no Jardim Amazonas, Petrolina/PE. Frente ao fato de que o texto é materialidade discursiva com quem se interage para, a partir dele, proceder a uma análise crítico-reflexiva da realidade e posterior intervenção social, buscou-se, através de uma disciplina eletiva, criar condições para o estudante fosse capaz de realizar uma leitura nessa perspectiva. Para isso, através de uma disciplina eletiva, de duas horas semanais, e duração de seis meses, os estudantes vivenciaram a Tertúlia Literária Dialógica, em torno do livro “Na minha pele”, de Lázaro Ramos, a qual aborda questões étnico-raciais, destacando situações em que foi vítima de racismo – desde entrevistas de emprego até ações cotidianas, como sacar um dinheiro em um caixa eletrônico, além de discutir questões relativas à história do negro no Brasil, à escravidão, à cultura, à religião, à marginalização, ao racismo estrutural, etc. Durante os encontros, a partir das interações e intervenções, foi-se evidenciando o desenvolvimento de um olhar crítico-social para o texto, consolidado nos relatos orais e escritos, nas produções imagéticas, nos gestos de referenciações a outras obras – música “Olhos Coloridos”, interpretada por Sandra de Sá, e “Manual Antirracista”, de Djamila Ribeiro –, assim como na proposta de musical à comunidade escolar. Assim, no ambiente escolar, as práticas de multiletramento se efetivaram, estando alinhadas aos objetivos de aprendizagem presentes na BNCC. Para análise dos resultados, optou-se por uma abordagem qualitativa (GODOY, 1995), procedendo à descrição das materialidades.
UTILIZAÇÃO DE CINZAS E EXTRATOS DE PLANTAS ESPONTÂNEAS NA NUTRIÇÃO MINERAL E PROTEÇÃO VEGETAL PARA O CULTIVO DE BETERRABAS
Authors: Santos Lucas Barbosa dos , Barbosa Flávia Silva , Guerra Antônia Mirian Nogueira de Moura , Andrea Vita Reis Medonça  , Silva Alicia Gonçalves , Aquino Tailande Novaes de
Published: January 2025

Os desafios tradicionais enfrentados na agricultura incluem a presença de herbívoros, fitopatógenos e plantas espontâneas. No entanto, estudos recentes apontam para uma perspectiva diferente, sugerindo que esses elementos podem indicar problemas no manejo agrícola, mas também oferecem oportunidades. As plantas espontâneas, em particular, têm sido reconhecidas como indicadoras de saúde do solo e podem desempenhar papéis benéficos na agricultura, assim como em setores como o farmacêutico e alimentício. Com o objetivo de explorar o potencial dessas plantas, realizamos um experimento para avaliar a eficácia de cinzas e extratos vegetais como protetores na cultura da Beta vulgaris esculenta. O experimento foi conduzido em casa de vegetação, em delineamento inteiramente casualizado, com oito   tratamentos e cinco repetições, totalizando 40 parcelas experimentais. Os   tratamentos avaliados foram compostos pela combinação de cinza vegetal, composto de esterco (esterco bovino) e solo na base de volume conhecido, solo como substrato, no qual constituiu a testemunha. A semeadura foi realizada diretamente em vasos do tipo floreiras retangulares (dimensões: 50cm x 17cm x 20cm - 17L), na densidade de 5 mudas/vaso. Os resultados revelaram que certos tratamentos, especialmente aqueles envolvendo cinzas da planta espontânea Sida cordifolia, tiveram impactos significativos no crescimento da parte aérea e na produção de raízes comestíveis da beterraba. Além disso, observou-se um aumento no diâmetro das raízes, indicando características favoráveis para o cultivo. Esses achados sugerem que a utilização de cinzas e extratos de plantas espontâneas pode ser uma estratégia promissora para melhorar várias características da cultura da beterraba, destacando-se a relevância da Sida cordifolia como uma potencial fonte de benefícios agrícolas.
Full 18S metabarcoding of environmental samples of various substrates with Nanopore sequencing. v2
Authors: Blandenier Quentin , Gibson Nicholas , K. Tice Alexander , E Jones Robert , P. Jones Erin , E. Baird Richard , A. Zurweller Brendan , W. Brown Matthew
Published: January 2025

We describe here a flexible protocol for eDNA metabarcoding with Oxford Nanopore's MinIon MK1C platform from sampling to sequencing. The first section summarizes some key steps of sampling and sample preservation for both aquatic and terrestrial environments. The second one describes the DNA extraction protocol with the DNeasy PowerSoil Pro Kit of Qiagen for different types of samples (i.e., soil, liquid and dead plant materials). Our DNA amplification and bead purification protocols are characterized in the third section. Finally, the library prep with the Native amplicon Barcoding Kit 96 V14 (SQK-NBD114.96) and sequencing with the R10.4.1 flow cells (FLO-MIN114) and MinION Mk1C device are presented in the last sections. This protocol has been optimized for protists (microbial eukaryotes) and 18S marker, but should be easily adjustable for other organisms, by modifying the sampling and DNA extraction sections, or other markers, even longer ones such as the full ribosomal operon, if need be. Our goal is to teach/train researchers from different fields and different expertise on obtaining nanopore sequences from environmental samples by guiding them from protocol to protocol, focusing on the key steps, and informing them of the expected results based on our 3 runs performed so far. A comprehensive bioinformatic pipeline to treat the data produced, as well as a methodological article discussing this method and the best ways to use it are in preparation.
Hans-Georg Gadamer’de Sanatın Anlamı
Authors: Avşar Devrim
Published: January 2025

Hans-Georg Gadamer, Hakikat ve Yöntem ve Güzelliğin Güncelliği adlı eserlerinde, sanatta meşruiyet sorununu oyun, sembol ve festival kavram üçlemesiyle ele alır. Gadamer, bu üç kavramın klasik sanat geleneği ile modern sanatın birliğini sağlayan insan deneyimlerinin antropolojik kökenlerine yönelik bilgiler sunduğu görüşündedir. Oyun, sembol ve festival kavramları insan türünün en eski deneyimlerinden günümüze kadar sürdüğü davranış formları şeklinde tanımlanır. Gadamer, sanatı da insan bilimlerinin yöntemlerine göre ele alarak, meşruiyet sorununu, kültürel bağlamların bir onayı şeklinde sunar. Çalışma, Gadamer’in sanatın meşruiyeti sorununu ele alınırken, meşruiyet kavramının tarihsel bağlamına yönelir. Bu çerçevede, meşruiyet durumunun, sanatı kontrol eden otoritelerin sanata yüklediği işlevle ilişkili olduğu görülür. Modern sanat tartışmalarının belirli bir kısmına yer verilerek yaşanan tartışmalardan açığa çıkan sorunların Gadamer’in yaklaşımıyla bazı değerlendirmeler yapılır. Makale içerik olarak Gadamer’in düşüncelerini sanatın meşruiyet sorunu çerçevesinde kuramsal ve kavramsal bir tartışma yürüten nitel bir çalışma örneği sunar. Çalışmada, öncelikle modern sanat akımlarının ortaya çıkış hikâyesine yer verilmiş ve sonrasında sanatın meşruiyet sorunu şeklinde ifade edilen tartışmalara nasıl evrildiği ele alınmıştır.
Her Şey Her Yerde Aynı Anda Filminde Zaman-İmge Görünümleri: Çoklu Evrenler, Katmanlar, Çatlak ve Farklılıklar
Authors: Nacar Evrim
Published: January 2025

Gilles Deleuze, sinema üzerine iki ciltlik çalışmasında Sinema I: Hareket-İmge (2014) ve Sinema II: Zaman-İmge (2021) ile sinema teorisine önemli katkılarda bulunmuştur. Bu iki imge türü sinemanın tarihsel dönemlere ayrılmasında belirleyici bir rol oynamıştır. Deleuze’ün ikinci ciltte detaylandırdığı zaman-imge kavramı belirsizliği, duraksamayı ve bellek katmanlarını odağına alır. Daniel Scheinert ve Daniel Kwan’ın yönettiği Her Şey Her Yerde Aynı Anda (2022) filmi de zaman-imge kavramıyla birlikte düşünüldüğünde, evrenler arası yolculuklar ve parçalanmış imgeler aracılığıyla bellek ve zamanın izafi doğasını keşfederek, geçmişin şimdiki zamana taşındığı çok katmanlı bir anlatı sunmaktadır. Film geçmiş ve şimdinin iç içe geçtiği bir bellek metaforu aracılığıyla oluşturduğu parçalanmış imgelerle, bellek ve zaman ilişkisi üzerine yeni düşünceler geliştirmekte ve geçmişi şimdiki zamana, şimdiki zamanı çoklu evrenlere taşıyan kurgusuyla zamanın dolaysız bir imgesini sunmaktadır. Bu bağlamda film zaman-imge sinemasına özgü izafi zaman, süre ve bellek kavramları ekseninde felsefi eleştiri yöntemiyle incelenmiştir.