bluuebunny/crossref_metadata_2025 huggingface dataset:
Fate identification and management strategies of non-recyclable plastic waste through the integration of material flow analysis and leakage hotspot modeling
Authors: Rinasti Aprilia Nidia , Ibrahim Indradhi Faisal , Gunasekara Kavinda , Koottatep Thammarat , Winijkul Ekbordin
Published: September 2022

Low priority on waste management has impacted the complex environmental issue of plastic waste pollution, as evident by results of this study where it was found that 24.3% of waste generation in Jakarta and Bandung is emitted into the waterway due to the high intensity of human activity in the urban area. In this study, we investigated the viable integration between material flow analysis and leakage hotspot modeling to improve management strategies for plastic pollution in water systems and open environments. Using a multi-criteria assessment of plastic leakage from current waste management, a material flow analysis was developed on a city-wide scale defining the fate of plastic waste. Geospatial analysis was assigned to develop a calculation for identification and hydrological analysis while identifying the potential amount of plastic leakage to the river system. The results show that 2603 tons of plastic accumulated along the mainstream of the Ciliwung River on an annual basis, and a high-density population like that in Bandung discarded 1547 tons in a one-year period to the Cikapundung River. The methods and results of this study are applicable towards improving the control mechanisms of river rejuvenation from plastic leakage by addressing proper management in concentrated locations.
Metabolic remodeling of pyrimidine synthesis pathway and serine synthesis pathway in human glioblastoma
Authors: Nakamizo Akira , Miyamatsu Yuichiro , Hirose Haruka , Amano Toshiyuki , Matsuo Satoshi , Fujiwara Minako , Shimamura Teppei , Yoshimoto Koji
Published: September 2022

Glioblastoma is the most common brain tumor with dismal outcomes in adults. Metabolic remodeling is now widely acknowledged as a hallmark of cancer cells, but glioblastoma-specific metabolic pathways remain unclear. Here we show, using a large-scale targeted proteomics platform and integrated molecular pathway-level analysis tool, that the de novo pyrimidine synthesis pathway and serine synthesis pathway (SSP) are the major enriched pathways in vivo for patients with glioblastoma. Among the enzymes associated with nucleotide synthesis, RRM1 and NME1 are significantly upregulated in glioblastoma. In the SSP, SHMT2 and PSPH are upregulated but the upstream enzyme PSAT1 is downregulated in glioblastoma. Kaplan–Meier curves of overall survival for the GSE16011 and The Cancer Genome Atlas datasets revealed that high SSP activity correlated with poor outcome. Enzymes relating to the pyrimidine synthesis pathway and SSP might offer therapeutic targets for new glioblastoma treatments.
Multicolor multifocal 3D microscopy using in-situ optimization of a spatial light modulator
Authors: Amin M. Junaid , Zhao Tian , Yang Haw , Shaevitz Joshua W.
Published: September 2022

Multifocal microscopy enables high-speed three-dimensional (3D) volume imaging by using a multifocal grating in the emission path. This grating is typically designed to afford a uniform illumination of multifocal subimages for a single emission wavelength. Using the same grating for multicolor imaging results in non-uniform subimage intensities in emission wavelengths for which the grating is not designed. This has restricted multifocal microscopy applications for samples having multicolored fluorophores. In this paper, we present a multicolor multifocal microscope implementation which uses a Spatial Light Modulator (SLM) as a single multifocal grating to realize near-uniform multifocal subimage intensities across multiple wavelength emission bands. Using real-time control of an in-situ-optimized SLM implemented as a multifocal grating, we demonstrate multicolor multifocal 3D imaging over three emission bands by imaging multicolored particles as well as Escherichia coli (E. coli) interacting with human liver cancer cells, at $$\sim 2.5$$

∼
2.5

multicolor 3D volumes per second acquisition speed. Our multicolor multifocal method is adaptable across SLM hardware, emission wavelength band locations and number of emission bands, making it particularly suited for researchers investigating fast processes occurring across a volume where multiple species are involved.
Effects of different water management and fertilizer methods on soil temperature, radiation and rice growth
Authors: Zheng Ennan , Hu Jianyu , Zhu Yinhao , Xu Tianyu
Published: September 2022

In recent decades, the application of organic fertilizer to agricultural soils has attracted wide attention. However, few studies have carefully explored the effects of humic acid fertilizer on soil temperature, radiation, and the physiology of plant leaves, especially when coupled with different irrigation methods. To provide a better growing environment for crops and explore the best regulation method of humic acid fertilizer and irrigation in the farmland soil environment on the Songnen Plain, China, through field experiments, we selected rice as the test crop and applied humic acid fertilizer to the soil with different irrigation methods. The effects of different humic acid fertilizers and irrigation methods on the soil temperature and radiation changes during different growth stages were examined, and the subtle differences in agronomic and fluorescence characteristics in different growth stages of rice plants were compared. The results showed that the soil temperature was not significantly different among all the treatments. However, radiation interception was obviously different, and the best value was observed in the CT5 treatment. The fluorescence indices and leaf chlorophyll relative content (SPAD) differed with the change in humic acid fertilizer application and irrigation methods. At the jointing and heading stages, the Fv/Fm values of the CT5, FT5 and WT5 treatments were larger than those of the other treatments, and the best value was recorded in the CT5 treatment. The differences in NPQ at these two stages were significant, and the NPQ in the CT5 treatment was significantly higher than that in the other treatments (P < 0.05). In general, the QP under control irrigation was greater than that under flood and wet irrigation (P < 0.05). Moreover, there were no significant differences among the gradients under the different humic acid fertilizer application methods in terms of QP (P > 0.05). Additionally, SPAD values were higher under the CT5 and FT5 treatments.
Formulation of a glycolipid:lipopeptide mixture as biosurfactant-based dispersant and development of a low-cost glycolipid production process
Authors: Subsanguan Tipsuda , Khondee Nichakorn , Rongsayamanont Witchaya , Luepromchai Ekawan
Published: September 2022

Biosurfactant-based dispersants were formulated by mixing glycolipids from Weissella cibaria PN3 and lipopeptides from Bacillus subtilis GY19 to enhance the synergistic effect and thereby achieve hydrophilic-lipophilic balance. The proportions of each biosurfactant and dispersant-to-oil ratios (DORs) were varied to obtain the appropriated formulations. The most efficient glycolipid:lipopeptide mixtures (F1 and F2) had oil displacement activities of 81–88% for fuel and crude oils. The baffled flask test of these formulations showed 77–79% dispersion effectiveness at a DOR of 1:25. To reduce the cost of the dispersant, this study optimized the glycolipid production process by using immobilized cells in a stirred tank fermenter. Semicontinuous glycolipid production was carried out conveniently for 3 cycles. Moreover, food wastes, including waste coconut water and waste frying oil, were found to promote glycolipid production. Glycolipids from the optimized process and substrates had similar characteristics but 20–50% lower cost than those produced from basal medium with soybean oil in shaking flasks. The lowest cost dispersant formulation (F2*) contained 10 g/L waste-derived cell-bound glycolipid and 10 g/L lipopeptide and showed high dispersion efficiency with various oils. Therefore, this biosurfactant-based dispersant could be produced on a larger scale for further application.
Health-related behavioral changes and incidence of chronic kidney disease: The Japan Specific Health Checkups (J-SHC) Study
Authors: Kimura Hiroshi , Asahi Koichi , Tanaka Kenichi , Iseki Kunitoshi , Moriyama Toshiki , Yamagata Kunihiro , Tsuruya Kazuhiko , Fujimoto Shouichi , Narita Ichiei , Konta Tsuneo , Kondo Masahide , Kasahara Masato , Shibagaki Yugo , Watanabe Tsuyoshi , Kazama Junichiro J.
Published: September 2022

The transtheoretical model (TTM) is a commonly used model of health-related behavioral change. However, the practical effect of using this model for chronic kidney disease (CKD) self-management remains unclear. This study aimed to investigate the association between stages of change for lifestyle behavior and the incidence of CKD in the general Japanese population. A retrospective cohort study was conducted among 178,780 non-CKD participants aged 40–74 years who underwent annual health check-ups for two consecutive years between 2008 and 2009. Health behavior change was determined using questionnaires based on the TTM, which consists of five stages of change (precontemplation, contemplation, preparation, action, and maintenance). The exposure of interest was the change in stages between two years. Participants were categorized into 3 groups ‘improved’, ‘unchanged’, or ‘deteriorated’. The association between the change in stages and the incidence of CKD was examined using logistic regression analysis. After one year of follow-up, 20.0% of participants developed CKD. Participants in the deteriorated group showed a significantly higher risk of CKD incidence than in the improved group. Promoting the stage of change for healthy lifestyle behaviors evaluated by the TTM was associated with a risk reduction for the incidence of CKD.
Plasma galectin-3 concentration and estimated glomerular filtration rate in patients with type 2 diabetes with and without albuminuria
Authors: Chung Jin Ook , Park Seon-Young , Lee Seung Baek , Kang Na-Ri , Cho Dong Hyeok , Chung Dong Jin , Chung Min Young
Published: September 2022

This study aimed to investigate the association between galectin-3 concentration and estimated glomerular filtration rate (eGFR) in patients with type 2 diabetes mellitus (T2DM) with and without albuminuria. In this cross-sectional study, we examined 334 patients with T2DM. The eGFR was calculated using a creatinine-based formula (eGFRcrea) and a combined creatinine-cystatin C equation (eGFRcrea-cyst). The participants were categorized into two groups based on the urinary albumin-to-creatinine ratio (UACR): patients without albuminuria (UACR < 30 mg/g) and those with albuminuria (UACR ≥ 30 mg/g). Greater concentrations of plasma galectin-3 were associated with lower eGFRcrea-cyst and eGFRcrea levels in patients with and without albuminuria. Plasma galectin-3 concentrations were negatively correlated with eGFRcrea-cyst in patients with normoalbuminuria and albuminuria (γ = − 0.405, P < 0.001; γ = − 0.525, P < 0.001, respectively). Galectin-3 concentrations were significantly associated with eGFRcrea-cyst after adjusting for sex, age, and other confounding factors, including UACR as a categorical or continuous variable in multiple regression analyses (β = − 0.294, 95% CI − 70.804 to − 41.768, P < 0.001; β = − 0.265, 95% CI − 65.192 to − 36.550, P < 0.001, respectively). Likewise, when eGFRcrea-cyst was treated in place of eGFRcrea, this result was replicated in the correlation and regression analyses. Galectin-3 concentration was negatively associated with eGFR in patients with T2DM, independent of albuminuria status.
Following the niche: the differential impact of the last glacial maximum on four European ungulates
Authors: Leonardi Michela , Boschin Francesco , Boscato Paolo , Manica Andrea
Published: September 2022

Predicting the effects of future global changes on species requires a better understanding of the ecological niche dynamics in response to climate; the large climatic fluctuations of the last 50,000 years can be used as a natural experiment to that aim. Here we test whether the realized niche of horse, aurochs, red deer, and wild boar changed between 47,000 and 7500 years ago using paleoecological modelling over an extensive archaeological database. We show that they all changed their niche, with species-specific responses to climate fluctuations. We also suggest that they survived the climatic turnovers thanks to their flexibility and by expanding their niche in response to the extinction of competitors and predators. Irrespective of the mechanism behind such processes, the fact that species with long generation times can change their niche over thousands of years cautions against assuming it to stay constant both when reconstructing the past and predicting the future.
Human thymoma-associated mutation of the GTF2I transcription factor impairs thymic epithelial progenitor differentiation in mice
Authors: Giorgetti Orlando B. , Nusser Anja , Boehm Thomas
Published: September 2022

Few human tumours present with a recurrent pathognomonic mutation in a transcription factor. Thymomas are an exception, with the majority of some subtypes exhibiting a distinct somatically acquired missense mutation in the general transcription factor GTF2I. Co-dominant expression of wild-type and mutated forms of Gtf2i in the mouse thymic epithelium is associated with aberrant thymic architecture and reduced thymopoietic activity. Phenotypic and molecular characterization of the mutant epithelium indicates that medullary differentiation is particularly affected as a result of impaired differentiation of bi-potent epithelial progenitors. The resulting gene expression signature is dominated by that of immature cortex-like thymic epithelial cells. TCR repertoire analysis of the cytopenic T cell compartment indicates efficient intrathymic selection; hence, despite marked homeostatic proliferation of T cell clones, autoimmunity is not observed. Thus, our transgenic mouse model recapitulates some aspects of the pathophysiology of a genetically defined type of human thymoma.
Interruption of aberrant chromatin looping is required for regenerating RB1 function and suppressing tumorigenesis
Authors: Wen Xuyang , Ding Tianyi , Li Fang , Fan Jiayan , Fan Xianqun , Jia Renbing , Zhang He
Published: September 2022

RB transcriptional corepressor 1 (RB1) is a critical regulatory gene in physiological and pathological processes. Genetic mutation is considered to be the main cause of RB1 inactivation. However, accumulating evidence has shown that not all RB1 dysfunction is triggered by gene mutations, and the additional mechanism underlying RB1 dysfunction remains unclear. Here, we firstly reveal that a CCCTC binding factor (CTCF) mediated intrachromosomal looping served as a regulatory inducer to inactivate RB1. Once the core genomic fragment was deleted by Clustered Regularly Interspaced Short Palindromic Repeats/Cas9 (CRISPR/Cas9), this intrachromosomal looping was disrupted. After the open of chromatin, Enhancer of Zeste Homolog 2 (EZH2) was released and decreased the level of Tri-Methyl-Histone H3 Lys27 (H3K27me3) at the RB1 promoter, which substantially restored the expression of RB protein (pRB) and inhibited tumorigenesis. In addition, targeted correction of abnormal RB1 looping using the small-molecule compound GSK503 efficiently restored RB1 transcription and suppressed tumorigenesis. Our study reveals an alternative transcriptional mechanism underlying RB1 dysfunction independent of gene mutation, and advancing the discovery of potential therapeutic chemicals based on aberrant chromatin looping.
Highly diastereo- and branched-selective rearrangement of substituted N-alloc-N-allyl ynamides
Authors: Jackson Oliver D. , Stankevich Ksenia S. , Cook Matthew J.
Published: September 2022

The use of a single palladium catalyst to perform two mechanistically distinct allylic rearrangements in excellent diastereoselectivity is described.
Stepwise structure evolution from 2D cluster-based frameworks to silver(i) clusters
Authors: Zang Qiu-Xu , Wang Zhao-Yang , Li Yao , Luo Xi-Ming , Li Hai-Yang , Si Ya-Nan , Zang Shuang-Quan
Published: September 2022

The transformation process of Ag5 cluster-based assemblies accompanied by changing luminescence and activating the CPL signal is reported.
Catalytic enantioselective hydrophosphinylation of in situ-generated indole-derived vinylogous imines to access 3-(1-diphenylphosphoryl-arylmethyl)indoles
Authors: Jia Yun-Qing , Zhao Jian-Qiang , Wang Zhen-Hua , You Yong , Zhang Yan-Ping , Jin Xin , Zhou Ming-Qiang , Ge Zhen-Zhen , Yuan Wei-Cheng
Published: September 2022

An efficient organocatalyzed enantioselective hydrophosphinylation of indole-derived vinylogous imines generated in situ from sulfonyl indoles was developed for the synthesis of optically active 3-(1-diphenylphosphoryl-arylmethyl)indoles.
Enhanced field emission of quasi-aligned 3C-SiC nanoarrays alloyed with tiny Co nano-tips
Authors: Chen Youqiang , Zhang Xinni
Published: September 2022

We have successfully demonstrated quasi-aligned 3C-SiC nanoarrays with tiny cobalt nanotips as new-type hetero-structure based field emitters, which thus offer the superior field emission properties with much lower turn-on field.
Hydrothermal synthesis of anisotropic SrGe4O9:Yb3+/Er3+ nanorods and optimized upconversion luminescence for optical temperature sensing
Authors: Qin Zhaoting , Xu Junhao , Zeng Lingwei , Liu Jing , Li Guannan , Li Chunmei , Hu Shanshan , Yang Jun , Tang Jianfeng
Published: September 2022

Anisotropic Yb3+/Er3+ co-doped SrGe4O9 nanorods were prepared for upconversion luminescence. The fluorescence intensity ratio (FIR) of the adjacent upconverted green emissions was applied to optical temperature measurement.
Mechanical, electronic and catalytic properties of 2H–1T′ MoS2 heterointerfaces
Authors: Huang Xiangru , Chang Yuan , Qiu Shi , Liu Hongsheng , Shymanski Vitali , Gao Junfeng
Published: September 2022

Compared with the 2H and 1T′ MoS2 phases, 2H–1T′ MoS2 in-plane heterointerfaces exhibit a much better catalytic activity for the hydrogen evolution reaction, which can be further tuned using strain engineering.
Spatial programming of self-organizing chemical systems using sustained physicochemical gradients from reaction, diffusion and hydrodynamics
Authors: Nguindjel Anne-Déborah C. , de Visser Pieter J. , Winkens Mitch , Korevaar Peter A.
Published: September 2022

We highlight four different concepts that can be used as a design principe to establish self-organization using chemical reactions as a driving force to sustain gradients: reaction–diffusion, reaction–convection, Marangoni flow and diffusiophoresis.
Effects of alkali ion dopants on the transport mechanisms and the thermal stabilities of imidazolium-based organic ionic plastic crystals
Authors: Park Chung Bin , Sung Bong June
Published: September 2022

The type of alkali ion dopant can alter the thermal stability and transport mechanisms of the organic plastic crystals (OIPCs).
In-plane CrI2/CrI3 2D superlattices: novel electronic properties and strain induced phase transition
Authors: Zhao Yuanyuan , Liu Hongsheng , Zhao Jijun , Gao Junfeng
Published: September 2022

CrI2/CrI3 superlattices with a zigzag interface are magnetic semiconductors with robust space charge separation. The magnetic order can be effectively tuned by the width of CrI2 ribbons in the superlattice.
The unique photoelectronic properties of the two-dimensional Janus MoSSe/WSSe superlattice: a first-principles study
Authors: Zhang Huanhuan , Deng Dawei , Zou Dai-Feng , Li Xi-Bo , Tang Zhen-kun , Wei Xiao-Lin , Ge Qing-Xia , Yin Wen-Jin
Published: September 2022

Designing photocatalysts with suitable band alignment and considerable carrier mobility is extremely important.
Photo-splitting xylose and xylan to xylonic acid and carbon monoxide
Authors: Zhang Junqiang , Liu Kangning , Sun Shaolong , Sun Runcang , Ma Jiliang
Published: September 2022

Simultaneous direct production of fuels and chemicals via photocatalytic biomass conversion is an effective strategy to achieve the carbon-neutral goal but no studies on the co-production of CO and xylonic acid have been reported.
High resolution off resonant spectroscopy as a probe of the oxidation state
Authors: Nowakowski Michal , Kalinko Aleksandr , Szlachetko Jakub , Fanselow Rafał , Bauer Matthias
Published: September 2022

The direct conversion between HEROS-XES and XANES edge position (E0) without need of measuring absorption spectra.
High-precision EPMA measurement of trace elements in ilmenite and reference material development
Authors: Jia Li-Hui , Mao Qian , Tian Heng-Ci , Li Li-Xing , Qi Liang , Wu Shi-Tou , Yuan Jiang-Yan , Huang Liang-Liang , Chen Yi
Published: September 2022

A natural ilmenite (PZH12-09) is homogeneous and thus suitable for use as a reference material forin situmicroanalysis. An EPMA method was developed to determine the trace elements of ilmenite, with high precision and low detection limits.
Spectroscopic and theoretical insights into hydrogen bonding clusters, triplet species, and the relaxation mechanism of the light (1ππ*) excited state of 4-methyl-1,2,4-triazole-3-thione
Authors: Li Yu , Liu Bo-Long , An Suosuo , Zhao Yanying , Xue Jiadan , Zheng Xuming , Xie Bin-Bin
Published: September 2022

Microsolvated hydrogen bonding 4-methyl-1,2,4-triazole-3-thione clusters were characterized experimentally and theoretically in solvents. The mechanism of the excited-state decay and the long-term triplet formation was proposed by CASSCF calculation.
A new method for creating Se–N intramolecular bonds using UV radiation
Authors: Pacuła-Miszewska Agata J. , Obieziurska-Fabisiak Magdalena , Laskowska Anna , Kaczmarek Halina , Ścianowski Jacek
Published: September 2022

Se–N bond formation supported by UV-light.
Enhanced photocatalytic hydrogen peroxide production activity of imine-linked covalent organic frameworksviamodification with functional groups
Authors: Yang Yepeng , Kang Juanxue , Li Yuan , Liang Jingjing , Liang Jiaxuan , Jiang Liang , Chen Daomei , He Jiao , Chen Yongjuan , Wang Jiaqiang
Published: September 2022

Solar-driven photocatalytic H2O2production with water and O2is an environmentally friendly process for producing H2O2, an important chemical.
One-pot synthesis of a PtCu alloy catalyst for the methanol oxidation reaction
Authors: Li Lianjie , Zhao Yican , Lei Zuotao , Yang Chunhui
Published: September 2022

The initial mass activity and specific activity of each catalyst sample, as well as the mass activity and specific activity after 1000 cycles, are evident from the graphs.
Alkali metal salts-assisted coupling reaction between fluorinated benzyl electrophiles and alkenylboronic acids
Authors: Xie Wenna , Liu Shiwen , Hammond Gerald B. , Xu Bo
Published: September 2022

Transition metal-free ion pair assisted nucleophilic substitution reactions.
Unravelling the electromechanical coupling in a graphene/bulk h-BN heterostructure
Authors: Jiang Xingan , Zhang Xiangping , Han Xiangyan , Lu Jianming , Wang Xueyun , Hong Jiawang
Published: September 2022

The topographic corrugation and flexoelectric potential distribution of moire pattern.
Chemoselective, osmium-free, dihydroxylation/oxidative cleavage of heteroaryl isoprenes by a contemporary Malaprade reaction
Authors: Gulledge Zachary Z. , Pinson Connor C. , Stovall Alexander M. , Dzeagu Fortune O. , Carrick Jesse D.
Published: September 2022

Dihydroxylation/oxidative cleavage of functionalized isoprenes leveraging KMnO4 as a greener alternative to OsO4 chemoselectively affords heteroaryl methyl ketones.
Dense packings of geodesic hard ellipses on a sphere
Authors: Gnidovec Andraž , Božič Anže , Čopar Simon
Published: September 2022

In systems of 2D geodesic spherical ellipses, the curvature of the underlying spherical surface introduces frustration in local and global order, resulting in disordered monodispersed packings.
Defect dynamics in active polar fluidsvs.active nematics
Authors: Vafa Farzan
Published: September 2022

Defect interactions can be deduced by a variational method.
Learning body part‐based pose lexicons for semantic action recognition
Authors: Zhou Lijuan , Jiang Tao
Published: September 2022

Semantic action recognition aims to classify actions based on the associated semantics, which can be applied in video captioning and human‐machine interaction. In this paper the problem is addressed by jointly learning multiple pose lexicons based on multiple body parts. Specifically, multiple visual pose models are learnt, and one visual pose model is associated with one body part, which characterises the likelihood of an observed video frame being generated from hidden visual poses. Moreover, multiple pose lexicon models are simultaneously learnt along with visual pose models. One pose lexicon model is associated with one body part that establishes a probabilistic mapping between the hidden visual poses and semantic poses parsed from textual instructions. To capture the temporal relations among body parts, a transition model is also learnt to measure the probability of the alignment transitioned from one position to another position. The body part‐based pose lexicon learning provides a novel method of cross‐modality semantic correlation, which can be applied in other spatial and temporal data. Action classification is finally formulated as the problem of finding the maximum posterior probability that a given multiple sequences of visual frames follow multiple sequences of semantic poses, subject to the most likely visual pose sequences and alignment sequences. Experiments were conducted on five action datasets to validate the effectiveness of the proposed method.
Cooperative jamming resource allocation model and algorithm for netted radar
Authors: Yao Zekun , Tang Chuanbin , Wang Chao , Shi Qinzhan , Yuan Naichang
Published: September 2022

In this letter, the jamming resource allocation problem of distributed jammers cooperatively jamming netted radar system is investigated. A well‐constructed jamming resource allocation model considering jamming beams, jamming power and other influencing factors is established. Random keys are used in this letter to improve the coding mode of genetic algorithm. Simulation results show that in the case of limited jamming resources, the model and algorithm proposed can achieve effective jamming allocation schemes facing a netted radar with any number of radar nodes.
Absolute colors and phase coefficients of asteroids
Authors: Alvarez-Candal A. , Jimenez Corral S. , Colazo M.
Published: September 2022

Context. We use the phase curves of small bodies to measure absolute magnitudes and, together with complementary theoretical and laboratory results, to understand the micro- and macroscopic properties of their surfaces. Although we can observe asteroids up to phase angles of about 30 deg, the range of phase angles covered by outer Solar System objects usually does not go further than 7−10 deg for centaurs and 2 deg for trans-Neptunian objects, and a linear relation between magnitude and phase angle may be assumed.

Aims. We aim to directly compare data taken for objects in the inner Solar System (inside the orbit of Jupiter) with data for centaurs and trans-Neptunian objects.

Methods. We use the SLOAN Moving Objects Catalog (MOC) data to construct phase curves restricted to phase angles of less than or equal to 7.5 deg, which is compatible with the angles observed for the trans-Neptunian and Centaur population. We assume a linear model for the photometric behavior to obtain absolute magnitudes and phase coefficients in the ugirz, V, and R filters.

Results. We obtain absolute magnitudes in seven filters for over 4000 objects. Our comparison with outer Solar System objects suggests the surfaces have a common property: intrinsically redder objects become blue with increasing phase angle, while the opposite happens for intrinsically bluer objects.
Open clusters housing classical Cepheids in Gaia DR3
Authors: Hao C. J. , Xu Y. , Wu Z. Y. , Lin Z. H. , Bian S. B. , Li Y. J. , Liu D. J.
Published: September 2022

The latest Gaia Data Release 3 provides an opportunity to expand the census of Galactic open clusters harboring classical Cepheid variables, thereby bolstering the cosmic distance scale. A comprehensive analysis yielded a total of 50 classical Cepheids associated with 45 open clusters, of which 39 open cluster-classical Cepheid pairs are considered probable, with the remaining 11 pairs considered improbable but worth following up. Two previously identified clusters by us possibly host classical Cepheids (OC-0125/V1788 Cyg and OC-0675/OGLE-BLG-CEP-114). In addition, we identify 38 new open cluster candidates within the Galactic disk.
Dirigentenunseres Handelns – Hormone
Authors: Aegler Barbara , Delmée Céline
Published: September 2022

Sie beeinflussen Emotionen, den Tag-Nacht-Rhythmus, die Wundheilung und vieles mehr – Hormone. Sie bilden ein hochkomplexes System, das je nach Tageszeit, Nahrungsaufnahme, emotionalem Status, Heilungszustand und unserem Handeln stets in Bewegung ist. Und das Beste ist: Hormone lassen sich mit gezielten Aktivitäten beeinflussen.
Synthesis of Benzoazepinone Derivatives via Photoredox Deaminative Radical Cascade Alkylation of 1,7-Dienes and 1,7-Enynes
Authors: Correia José Tiago M. , Paixão Márcio W. , de Souza Wanderson C. , Lima Rafaely N. , de Jesus Iva S.
Published: September 2022

A deaminative alkyl radical cascade cyclization of 1,7-dienes is described under visible-light photocatalysis. This method delivers a family of benzoazepinones (benzazepinones) and occurs under mild reaction conditions to access a broad substrate scope with excellent functional group tolerance and good yields. This protocol has also been extended to 1,7-enynes, furnishing a representative collection of cyclopentaquinolinones.
Ring-System-Based Conformational Switches and their Applications in Sensing and Liposomal Drug Delivery
Authors: Pedersen Christian Marcus , Su Hang
Published: September 2022

In the past decades, a great number of stimuli-responsive systems have been developed to be used as drug-delivery systems with high sensitivity and selectivity in targeted therapy. Despite promising results, the current stimuli-responsive systems suffer from the complexity of preparation, as most novel stimuli-responsive systems are based on polymers. Small molecules have often been neglected as candidates for application for stimuli-responsive systems. Recently, structures based on six-membered ring molecules or bicyclic molecules have been developed into conformational switches working through conformational interconversion. These single conformational switches have significantly reduced the complexity of material preparation compared to polymers or copolymers. In this review, we focus on ring-system-based conformational switches that are involved in sensors and smart drug-delivery systems. We hope that this review will shed light on ring-system-based single conformational switches for use in the development of stimuli-responsive systems.

1 Introduction2 Conformation Switches Based On Bispidine Derivatives3 Conformation Switches Based On Cycloalkanes4 Conformation Switches Based On Carbohydrates5 Conclusion
Therapy for Recurrent High-Grade Epithelial Ovarian Cancer—The Current Status and Future Trends
Authors: Harindran Vallathol Dilip , Sadanandan V.P. Sanudev , Sreedath P. Vishnu , Prashanth Parameswaran , Sajeevan K.V. , Sreedharan P.S. , Warrier Narayanankutty
Published: September 2022

Ovarian malignancy is the seventh most frequently diagnosed cancer among women. The most common type is epithelial ovarian cancer. Several subtypes with distinct biological and molecular properties exist, and there is inconsistency in availability of and access to different modalities of treatment. The standard first-line management is combining surgery and platinum-based chemotherapy. Most of them are diagnosed at an advanced stage due to which they have poor outcomes. The existing screening tests have a low predictive value. Even with the best available upfront treatment, high rates of recurrences are observed. As a result, there have been major advances in the treatment of recurrences with the development of anti-angiogenic agents and PARP inhibitors. It has led to the improvement in survival and quality of life among the relapsed epithelial ovarian cancers. This review is focused on the management of recurrent epithelial ovarian cancers and future directions based on current evidence. The application of a personalized and structured approach will meaningfully bring changes in the paradigm of care in these groups of patients.
Immobilization of Solvatochromic Dyes on Transparent Cellulose Films: an Improved Method for the Study of Homeopathic Potencies
Authors: Cartwright Steven J.
Published: September 2022

Background Highly diluted and succussed solutions (homeopathic potencies) have been shown to interact with a wide range of solvatochromic dyes based on changes in their UV-visible spectra. Studies so far have involved free dyes in solution, but there is a pressing need to find ways to investigate the potency–dye interaction using isolated dye molecules to ask more searching physico-chemical questions regarding the fundamental nature of potencies.

Aims and Methods The aims of the present study have been to look for ways to covalently immobilize solvatochromic dyes onto transparent cellulose films and hence be in a position to investigate dye–potency interactions without the complication of dye–dye interactions, including dye aggregation, which can occur with free dyes in solution.

Results To date, a total of nine different dyes have been immobilized on cellulose films using epoxide activation of hydroxyl groups on the cellulose surface. Using this method, studies have begun looking at the time course of potency action on one of these immobilized dyes, Brooker's merocyanine. Results show that the interaction of Arsenicum 10M with this dye consists of three phases—an initial growth phase, a sustained plateau of interaction, and a final decline phase lasting several days.

Conclusion A method has been developed that successfully immobilizes solvatochromic dyes onto transparent cellulose film. These films can then be used in a spectrophotometer to study at a much more detailed level how potencies interact with dyes compared with using free dyes in solution. Results indicate that the information gained in this way provides new insights regarding the fundamental nature of potencies. Specifically, studies using immobilized Brooker's merocyanine with Arsenicum 10M reveal that the lifetime of the potency is much longer than expected and that its action consists of three distinct phases, suggesting a resonant interaction with the dye. How resonant interaction might help to explain the clinical action of potencies is discussed.
Heart Rate and Pulse Oximetry Dynamics in the First Week after Birth in Neonatal Intensive Care Unit Patients and the Risk of Cerebral Palsy
Authors: Letzkus Lisa , Fairchild Karen , Lyons Genevieve , Pyata Harshini , Ratcliffe Sarah , Lake Doug
Published: September 2022

Objective Infants in the neonatal intensive care unit (NICU) are at high risk of adverse neuromotor outcomes. Atypical patterns of heart rate (HR) and pulse oximetry (SpO2) may serve as biomarkers for risk assessment for cerebral palsy (CP). The purpose of this study was to determine whether atypical HR and SpO2 patterns in NICU patients add to clinical variables predicting later diagnosis of CP.

Study Design This was a retrospective study including patients admitted to a level IV NICU from 2009 to 2017 with archived cardiorespiratory data in the first 7 days from birth to follow-up at >2 years of age. The mean, standard deviation (SD), skewness, kurtosis and cross-correlation of HR and SpO2 were calculated. Three predictive models were developed using least absolute shrinkage and selection operator regression (clinical, cardiorespiratory and combined model), and their performance for predicting CP was evaluated.

Results Seventy infants with CP and 1,733 controls met inclusion criteria for a 3.8% population prevalence. Area under the receiver operating characteristic curve for CP prediction was 0.7524 for the clinical model, 0.7419 for the vital sign model, and 0.7725 for the combined model. Variables included in the combined model were lower maternal age, outborn delivery, lower 5-minute Apgar's score, lower SD of HR, and more negative skewness of HR.

Conclusion In this study including NICU patients of all gestational ages, HR but not SpO2 patterns added to clinical variables to predict the eventual diagnosis of CP. Identification of risk of CP within the first few days of life could result in improved therapy resource allocation and risk stratification in clinical trials of new therapeutics.

Key Points
50 Years of Pediatric Hemostasis: Knowledge, Diagnosis, and Treatment
Authors: Levy-Mendelovich Sarina , Cohen Omri , Klang Eyal , Kenet Gili
Published: September 2022

Studies from the past 50 years have contributed to the expanding knowledge regarding developmental hemostasis. This is a dynamic process that begins in the fetal phase and is characterized by physiological variations in platelet counts and function, and concentrations of most coagulation factors and the native coagulation inhibitors in early life, as compared with adulthood. The developmental hemostasis studies since the 1980 to 1990s established the laboratory reference values for coagulation factors. It was only a decade or two later, that thromboelastography (TEG) or (rotational thromboelastometry [ROTEM]) as well as thrombin generation studies, provided special pediatric reference values along with the ability to evaluate clot formation and lysis. In addition, global whole blood-based clotting assays provided point of care guidance for proper transfusion support to children hospitalized in intensive care units or undergoing surgery. Although uncommon, thrombosis in children and neonates is gaining increasing recognition, typically as a secondary complication in sick children. Bleeding in children, and particularly intracerebral hemorrhage in newborns, still represent a therapeutic challenge. Notably, our review will outline the advancements in understanding developmental hemostasis and its manifestations, with respect to the pathophysiology of thrombosis and bleeding complications in young children. The changes of transfusion policy and approach to thrombophilia testing during the last decade will be mentioned. Subsequently, a brief summary of the data on anticoagulant treatments in pediatric patients will be presented. Finally, we will point out the 10 most cited articles in the field of pediatric and neonatal hemostasis.
Mechanical Heart Valves, Pregnancy, and Bleeding: A Systematic Review and Meta-Analysis
Authors: Jakobsen Carina , Larsen Julie Brogaard , Fuglsang Jens , Hvas Anne-Mette
Published: September 2022

Anticoagulant therapy is essential in pregnant women with mechanical heart valves to prevent valve thrombosis. The risk of bleeding complications in these patients has not gained much attention. This systematic review and meta-analysis investigate the prevalence of bleeding peri-partum and post-partum in women with mechanical heart valves and also investigate whether bleeding risk differed across anticoagulant regimens or according to delivery mode. The present study was conducted according to The Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) statement. Studies reporting bleeding prevalence in pregnant women with mechanical heart valves receiving anticoagulant therapy were identified through PubMed and Embase on December 08, 2021. Data on bleeding complications, delivery mode, and anticoagulation therapy were extracted. A total of 37 studies were included, reporting 423 bleeding complications in 2,508 pregnancies. A meta-analysis calculated a pooled prevalence of 0.13 (95% confidence interval [CI]: 0.09–0.18) bleeding episodes per pregnancy across anticoagulant regimens. The combination of unfractionated heparin (UFH) and vitamin K antagonist (VKA) and single VKA therapy showed the lowest risk of bleeding (8 and 12%). Unexpectedly, the highest risk of bleeding was found in women receiving a combination of low-molecular-weight-heparin (LMWH) and VKA (33%) or mono-therapy with LMWH (22%). However, this could be dose related. No difference in bleeding was found between caesarean section versus vaginal delivery (p = 0.08). In conclusion, bleeding episodes are common during pregnancy in women with mechanical heart valves receiving anticoagulant therapy. A combination of UFH and VKA or VKA monotherapy showed the lowest risk of bleeding.
Brazilian practice guidelines for stroke rehabilitation: Part II
Authors: Minelli Cesar , Luvizutto Gustavo José , Cacho Roberta de Oliveira , Neves Luciana de Oliveira , Magalhães Sheila Cristina Sayuri Abe , Pedatella Marco Túlio Araújo , Mendonça Lucia Iracema Zanotto de , Ortiz Karin Zazo , Lange Marcos Christiano , Ribeiro Priscila Watson , Souza Luciane Aparecida Pascucci Sande de , Milani Cristiano , Cruz Daniel Marinho Cezar da , Costa Rafael Dalle Molle da , Conforto Adriana Bastos , Carvalho Fernanda Martins Maia , Ciarlini Bruna Silva , Frota Norberto Anizio Ferreira , Almeida Kelson James , Schochat Eliane , Oliveira Tatiana de Paula , Miranda Camila , Piemonte Maria Elisa Pimentel , Lopes Laura Cardia Gomes , Lopes Camila Galvão , Tosin Michelle Hyczy de Siqueira , Oliveira Bianca Campos , Oliveira Beatriz Guitton Renaud Baptista de , Castro Shamyr Sulyvan de , Andrade João Brainier Clares de , Silva Gisele Sampaio , Pontes-Neto Octávio Marques , Carvalho João José Freitas de , Martins Sheila C. Ouriques , Bazan Rodrigo
Published: September 2022

The Brazilian Practice Guidelines for Stroke Rehabilitation – Part II, developed by the Scientific Department of Neurological Rehabilitation of the Brazilian Academy of Neurology (Academia Brasileira de Neurologia, in Portuguese), focuses on specific rehabilitation techniques to aid recovery from impairment and disability after stroke. As in Part I, Part II is also based on recently available evidence from randomized controlled trials, systematic reviews, meta-analyses, and other guidelines. Part II covers disorders of communication, dysphagia, postural control and balance, ataxias, spasticity, upper limb rehabilitation, gait, cognition, unilateral spatial neglect, sensory impairments, home rehabilitation, medication adherence, palliative care, cerebrovascular events related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the future of stroke rehabilitation, and stroke websites to support patients and caregivers. Our goal is to provide health professionals with more recent knowledge and recommendations for better rehabilitation care after stroke.
Analyzing the past, improving the future: a multiscale opinion tracking model for optimizing business performance
Authors: Sigari Salman , Gandomi Amir. H.
Published: September 2022

The complexity of business decision-making has increased over the years. It is essential for managers to gain a confident understanding of their business environments in order to make successful decisions. With the growth of opinion-rich web resources such as social media, discussion forums, review sites, news corpora, and blogs available on the internet, product and service reviews have become an essential source of information. In a data-driven world, they will improve services and operational insights to achieve real business benefits and help enterprises remain competitive. Despite the prevalence of textual data, few studies have demonstrated the effectiveness of real-time text mining and reporting tools in firms and organizations. To address this aspect of decision-making, we have developed and evaluated an unsupervised learning system to automatically extract and classify topics and their emotion score in text streams. Data were collected from commercial websites, open-access databases, and social networks to train the model. In the experiment, the polarity score was quantified at four different levels: word, sentence, paragraph, and the entire text using Latent Dirichlet Allocation (LDA). Using subjective data mining, we demonstrate how to extract, summarize, and track various aspects of information from the Web and help traditional information retrieval (IR) systems to capture more information. An opinion tracking system presented by our model extracts subjective information, classifies them, and tracks opinions by utilizing location, time, and reviewers’ positions. Using the online-offline data collection technique, we can update the library topic in real-time to provide users with a market opinion tracker. For marketing or economic research, this approach may be useful. In the experiment, the new model is applied to a case study to demonstrate how the business process improves.
Antisemitic comments on Facebook pages of leading British, French, and German media outlets
Authors: Becker Matthias J. , Ascone Laura , Troschke Hagen
Published: September 2022

We conducted a cross-national study on antisemitic hate speech on theFacebookprofiles of leading media outlets in the United Kingdom, France, and Germany. In a combination of qualitative pragmalinguistic analysis and quantitative analysis, we examined their comment sections concerning the conceptual and linguistic repertoire of verbal antisemitism in these three languages as well as to the frequency of antisemitic utterances. The corpus comprises 4500 comments (1500 for each language) made in reaction to the media’sFacebookposts reporting on an escalation phase of the Arab–Israeli conflict in May 2021. Since in antisemitism studies, Israel—and issues related to it—are widely perceived as today’s main pretext for communicating antisemitic resentment, unsurprisingly, those events led to the emergence of antisemitic content online. This article contrasts the findings of antisemitism in the three countries’ comment sections and illustrates them by presenting a variety of linguistic realisations of various antisemitic concepts and illustrates the corresponding steps of interpretation.
The relationship between leadership style and staff work engagement: An empirical analysis of the public sector in Vietnam
Authors: Thanh Nguyen Hai , Quang Nguyen Van , Anh Nguyen Ngoc
Published: September 2022

This analysis explores the relationship between transformational, transactional, and laissez-faire leadership styles with staff work engagement at the department level in the public sector in Vietnam. Using a cluster sampling method, a total of 378 participants were selected and agreed to participate in a survey by completing a questionnaire on the relationship between leadership style and work engagement. All participants are attendees of a training course for department-level leaders at the School of Culture, Sports, and Tourism Administration Officers under the Ministry of Culture, Sports, and Tourism of Vietnam. A regression was run on the collected data to test the hypothesis on the relationship between leadership styles and staff task performance. The regression results show that there is a significant indirect relationship between staff work engagement and innovative work behavior and task performance. In addition, there is a relatively positive relationship between the transformational leadership style and transactional leadership style of the department-level leaders in the Vietnamese public sector with staff work engagement, particularly innovative work behavior and task performance. On the contrary, laissez-faire leadership style negatively impacts staff work engagement and innovative work behavior. Staff work engagement is an integral part of the relationship between leadership style and leadership effectiveness. The findings suggest that the Vietnamese public sector should aim to identify transformational and transactional leaders. This research focuses on the department level and is limited to three leadership styles (transformational, transactional, and laissez-faire) only. Future research therefore can expand the scope to higher levels than the department leaders.