bluuebunny/crossref_metadata_2025 huggingface dataset:
Ihre Rechte als gesetzlich Krankenversicherter
Authors: Hauner Ralf
Published: August 2022

Ansprüche kennen, nutzen, durchsetzen

Die überwiegende Mehrheit ist in Deutschland gesetzlich krankenversichert. Welche Leistungen jeweils zustehen, ist jedoch oft nicht bekannt.

Dieser Leitfaden Ihre Rechte als gesetzlich Krankenversicherter führt durch die Leistungen, die verpflichtend von der Kasse erbracht werden müssen:

Förderung der Gesundheit

Prävention und Früherkennung

Ambulante und stationäre Leistungen

Zahnersatz

Leistungen für Schwangere, bei Mutterschaft

Krankengeld, Kinderkrankengeld

Heil- und Hilfsmittel

Digitale Gesundheitsanwendungen

Unterstützung bei Untersuchungen

Hospiz- und Palliativversorgung

Auf „heiße“ Eisen wie Ärztliche Zweitmeinung und Rechte bei chronischen Erkrankungen wird ebenso eingegangen wie auf verfahrensrechtliche Themen, etwa Widerspruch gegen Ablehnungen, direkte Abrechnung mit der Krankenkasse oder Kostenrückerstattung bei Überschreitung der Belastungsgrenze.
Establishment of Novel Non-stretched Penile Length (Flaccid) Cut-off Point and Normative Data in Iranian Prepubertal Children and its Significance: Observational Analytical Study
Authors: Rezakhaniha Bijan , Siroosbakht Soheila
Published: August 2022

Background: The penile aged-matched value should be determined to define abnormal penile length. Objectives: The purpose of this study was to establish novel reference values and flaccid penis length cut-off points for prepubertal children aged 6 - 15 years. Methods: In this study, 300 micropenis children were studied. In order to assess the diagnostic test power, 300 healthy boys were also evaluated as a control group. All children were divided into ten age groups (60 boys in each group). In order to obtain a non-stretched penile length (NSPL) cut-off point, stretched penile length (SPL) and NSPL mean values were separately calculated for each age group. We subtracted these two values to get the mean difference, which was subtracted from the standard SPL cut-off point to obtain the NSPL cut-off point for each age group. The receiver operating characteristic (ROC) curve and area under the curve (AUC) were defined to assess diagnostic test power. Results: NSPL cut-off point for the age groups of 6 - 7, 7 - 8, 8 - 9, 9 - 10, 10 - 11, 11 - 12, 12 - 13, 13 - 14, 14 - 15, and 15 - 16 years was 2.8, 2.9, 2.9, 3.8, 3.9, 4.4, 4.2, 4.8, 6.6, and 8.1 cm, respectively. Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of NSPL were 100% (95% CI, 98.53 - 100.00), 94.66% (95% CI, 89.77 - 96.28), 7.25% (95% CI, 4.64 - 11.16), 100%, and 97.33% (95% CI, 91.09 - 99.59), respectively. The AUC was 0.82, showing that the diagnostic power of the test was good. Conclusions: This study aimed to attain precise reference values of flaccid penis measurement for children. It seemed that the flaccid method is less observer-dependent, more tolerable, and repeatable. It should be mentioned that this new method does not replace the standard SPL method, while utilizing two reference values together can help to detect the size of the penis more accurately, especially in children. The new cut-off point can be used by all primary care practitioners and pediatric nurses as a reference for prepubertal boys to prevent misdiagnosis or overdiagnosis of micropenis.
Inflammatory Markers and Atherogenic Coefficient: Early Markers of Metabolic Syndrome
Authors: Mahdavi-Roshan Marjan , Shoaibinobarian Nargeskhatoon , Noormohammadi Morvarid , Fakhr Mousavi Aboozar , Savar Rakhsh Amir , Salari Arsalan , Ghorbani Zeinab
Published: August 2022

Background: Considering the close link between metabolic syndrome (MetSyn) and cardiovascular diseases, considerable attention has been devoted to the identification of their shared underlying pathological mechanisms in recent decades. Objectives: This study aimed to investigate the association between pro-inflammatory factors and newly-diagnosed MetSyn. Methods: This case-control study recruited obese and nonobese individuals who were newly diagnosed with MetSyn (cases, n = 84) and healthy individuals (controls, n = 83). The medical and sociodemographic data of the participants were collected on enrollment. Serum analysis was performed to ascertain the concentrations of tumor necrosis factor-alpha (TNF-α), C-reactive protein (CRP), fasting blood sugar (FBS), total cholesterol, triglyceride, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and atherogenic coefficient (AC). Multiple regression analysis was carried out to explore the relationship between inflammatory markers and AC with MetSyn odds. The Pearson correlation test was also performed to investigate the correlations between metabolic and inflammatory parameters. Results: Positive relationships were observed between the serum levels of TNF-α and CRP with the odds of MetSyn following controlling for confounders (adjusted odds ratio [AOR] = 1.32; 95% confidence interval [CI]: 1.01 - 1.72; AOR = 1.29; 95% CI: 1.18 - 1.41; respectively, P ≤ 0.03). Additionally, higher AC was accompanied by increased odds of MetSyn (AOR = 1.98; 95% CI: 1.31 - 2.98; P = 0.001). The Pearson correlation analysis also showed positive correlations between TNF-α levels and serum metabolic abnormalities, including elevated LDL-C, FBS, and AC and lowered HDL-C levels (P ≤ 0.02). Conclusions: The present results revealed that higher serum concentrations of pro-inflammatory and atherogenic indices, including CRP, TNF-α, and AC, might be associated with elevated odds of newly diagnosed MetSyn regardless of potential confounders, particularly body mass index. The obtained findings might be moderated by the positive correlations observed between serum TNF-α, as the chronic inflammatory state indicator, and impaired lipid and glycemic markers.
The Effect of Preoperative Intravenous Tranexamic Acid on the Amount of Bleeding in Patients Undergoing Cleft Palate Reconstruction Surgery
Authors: Dashti Khavidaki Gholamali , Yaghoubi Saeedeh , Naderi Majid , Malek Fatemeh
Published: August 2022

Background: Tranexamic acid (TXA) is an inexpensive therapy effective at minimizing perioperative blood loss and transfusion. However, it remains underutilized due to safety concerns. Cleft lip and cleft palate are among the most frequent congenital anomalies, accounting for 65% of head and neck anomalies, and 15000 neonates are born with these anomalies annually. Objectives: This study aimed to investigate the effect of preoperative intravenous TXA on hemorrhage in patients undergoing cleft palate reconstruction surgery in the Khatam Al-Anbia Hospital, Zahedan, Iran. Methods: This clinical trial was conducted on 60 patients undergoing palatoplasty in the Khatam Al-Anbia Hospital. The patients were randomly assigned into two groups: TXA receivers and controls. Data were collected using information forms and then analyzed using SPSS ver. 22. Results: The mean age of the participants was 21.42 ± 9.46 months, and of the 60 patients, 31 were boys, and 29 were girls. The mean bleeding volume was 11.73 ± 4.42 milliliter in the TXA receiving group and 17.36 ± 4.99 milliliters in the control group, and the mean duration of surgery was 41.90 ± 8.00 and 49.93 ± 11.37 minutes in the TXA receiving and control groups, respectively. The mean PT, PTT, and Hb were not significantly different before and after surgery in the two groups. Conclusions: Tranexamic acid causes a significant reduction in the duration of surgery and mean bleeding volume in palatoplasties, but it has no effects on PT, PTT, and Hb levels before and after surgery.
The Effect of Parent-Child Interaction Therapy on Separation Anxiety in 3-6-Year-old Children of Nurses
Authors: Zeighami Reza , Sarichloo Mohammad Ebrahim , Hosseinkhani Zahra , Zeynalzadeh Saedeh
Published: August 2022

Background: Separation anxiety disorder is considered as the most common anxiety disorder in childhood. Failure to treat this disorder in early age can be converted into a risk factor for childhood and adolescent psychiatric disorders. Objectives: This study aimed at investigating the effect of parent-child interaction therapy on reducing the symptoms of separation anxiety disorder among the nurses' children aged between 3 and 6 years old working in educational hospitals in Qazvin. Methods: The intervention was designed as pre- and post-test along with the control group. The sample included 67 children aged 3 - 6 years' old who were divided into intervention and control groups using the blocking method. The intervention consists of three steps: child directed interaction, bravery directed interaction and parent directed interaction which was performed for 8 sessions per weak. No intervention was performed for the control group. The obtained data were collected using the Spence questionnaire (parents' version) and the results were evaluated. Results: Intervention therapy significantly reduced the symptoms of separation anxiety in the intervention group at the post-test stage compared to the control group. The mean of separation anxiety decreased from 10.82 ± 0.62 to 7.69 ± 0.52 in the intervention group. Conclusions: Parent-child interaction therapy can be used as an effective treatment plan to reduce the symptoms of separation anxiety disorder among preschool children.
Icariin Exerts Estrogen-Like Actions on Proliferation of Osteoblasts in Vitro via Membrane Estrogen Receptors-Mediated Non-nuclear Effects
Authors: Zhang Dapeng , Su Yan , He Qiang , Zhang Yajie , Gu Ning , Zhang Xu , Yan Kun , Yao Nianwei , Qian Weiqing
Published: August 2022

Background: According to reports, icariin (ICA) is a bone anabolic agent able to prevent osteoporosis in both ovariectomized rats and postmenopausal women. However, its effect on osteoblast proliferation remains to be determined, and the underlying mechanism remains to be elucidated. Methods: Icariin-bovine serum albumin (BSA) conjugates were purified by Sephadex G-25 gel chromatography technology. Primary osteoblasts from neonatal rats were used to evaluate the effects of ICA, ICA-BSA, ICA-BSA + ICI182780, and ICA-BSA + PD98059. 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and propidium iodide (PI)-staining assays were used to detect the proliferation of osteoblasts after drug exposure. The intracellular calcium ions were detected using a confocal microscope with Fluo-3/AM as the fluorescent indicator. Western blot was capitalized on to measure the relative content of phospho-extracellular signal-regulated kinase (p-ERK). Results: Primary osteoblasts in culture were detected by histochemical staining of alkaline phosphatase, and calcified nodules were obtained by sequential digestion. Icariin and bovine serum albumin could form conjugate, which could be purified by Sephadex G-25 gel chromatography technology. MTT and flow cytometry results show that ICA-BSA conjugate significantly facilitated the proliferation of osteoblasts (P < 0.05). The intracellular calcium ions also ascended vastly in the cells treated with ICA-BSA conjugate (P < 0.01). Icariin-bovine serum albumin exposure rapidly activated the extracellular signal-regulated kinase (ERK) signaling. Furthermore, ICA- and ICA-BSA-mediated actions on osteoblasts were signally alleviated after dealing with ERK inhibitor PD98059 or estrogen receptor (ER) antagonist ICI182780, which might have a relation to the repression of ERK phosphorylation. Conclusions: Icariin could serve as estrogen in osteoblast cells by the rapid nongenomic ER signaling pathway independent of ligand and estrogen response element (ERE) and mediated by mitogen-activated protein kinase (MAPK).
Just Green Transition – key concepts and implications in the Nordic Region
Authors:   Nordregio, Cedergren Elin , Tapia Carlos , Sánchez Gassen Nora , Lundgren Anna
Published: August 2022

This discussion paper is a based on a literature review of the just green transition in a Nordic, European and OECD setting, via the lens of three interrelated dimensions within this concept: transition, green economy and social justice. The discussion paper starts by outlining the aim and the guiding questions. There then follows a section presenting the research methods and sources of material. Section 4 presents a review of the concepts transition, green economy and social justice, along with an overview of the overarching concept of the just green transition. This is followed by a discussion of its key implications in the Nordic Region. The section concludes with proposals for working definitions of concepts for the NJUST project.
Integration of Social Determinants of Health Data into the Largest, Not-for-Profit Health System in South Florida
Authors: Rojas Lourdes M. , Vincent Gregory L. , Parris Don
Published: August 2022

Social determinants of health (SDOH) are the conditions in which people are born, grow, work, and live. Although evidence suggests that SDOH influence a range of health outcomes, health systems lack the infrastructure to access and act upon this information. The purpose of this manuscript is to explain the methodology that a health system used to: 1) identify and integrate publicly available SDOH data into the health systems’ Data Warehouse, 2) integrate a HIPAA compliant geocoding software (via DeGAUSS), and 3) visualize data to inform SDOH projects (via Tableau). First, authors engaged key stakeholders across the health system to convey the implications of SDOH data for our patient population and identify variables of interest. As a result, fourteen publicly available data sets, accounting for >30,800 variables representing national, state, county, and census tract information over 2016–2019, were cleaned and integrated into our Data Warehouse. To pilot the data visualization, we created county and census tract level maps for our service areas and plotted common SDOH metrics (e.g., income, education, insurance status, etc.). This practical, methodological integration of SDOH data at a large health system demonstrated feasibility. Ultimately, we will repeat this process system wide to further understand the risk burden in our patient population and improve our prediction models – allowing us to become better partners with our community.
Images of architectural heritage in the cultural space
Authors: Khil'ko Nikolai Fedorovich , Gorelova Yuliya Robertovna
Published: August 2022

The subject of this article is the analysis of methodological aspects of the study of images of architectural heritage in the cultural space of the city. The object of the study is the architectural environment of the city as part of the architectural heritage. The author examines in detail such aspects of the topic as the influence of heritage on the positive image of the territory, the essence of the image and figurative characteristics of the city, factors of perception of urban space, directions of development of the architectural environment of the city, analysis of the figurative characteristics of the city, the state of architectural heritage. Special attention is paid to the methodology of analyzing images of cultural heritage, classification of figurative characteristics, substantiation of a new approach to the analysis of the architectural environment of the city. A special contribution of the authors to the study of the topic is the substantiation of a new methodological construct in the study of the subject field of the influence of figurative characteristics of the architectural environment of the city on the preservation of its cultural heritage. The novelty of the research is the new application of the figurative-symbolic approach to the study of cultural heritage in the images of architecture. The main conclusions of the study are: the need for the formation of an architectural environment, as well as significant activities to actualize and popularize cultural heritage, the active inclusion of images of architectural heritage in the semiotic field of the cultural space of the city, increasing awareness of the value of the architectural environment on the part of citizens.
Tornado of Life
Authors: Baruch Jay
Published: August 2022

Stories from the ER: a doctor shows how empathy, creativity, and imagination are the cornerstones of clinical care.

To be an emergency room doctor is to be a professional listener to stories. Each patient presents a story; finding the heart of that story is the doctor's most critical task. More technology, more tests, and more data won't work if doctors get the story wrong. When caring for others can feel like venturing into uncharted territory without a map, empathy, creativity, imagination, and thinking like a writer become the cornerstones of clinical care. In Tornado of Life, ER physician Jay Baruch shares these struggles in a series of short, powerful, and affecting essays that invite the reader into stories rich with complexity and messiness.

Patients come to the ER with lives troubled by scales of misfortune that have little to do with disease or injury. ER doctors must be problem-finders before they are problem-solvers. Cheryl, for example, whose story is a chaos narrative of “and this happened, and then that happened, and then, and then and then and then,” tells Baruch she is “stuck in a tornado of life.” What will help her, and what will help Mr. K., who seems like a textbook case of post-combat PTSD but turns out not to be? Baruch describes, among other things, the emergency of loneliness (invoking Chekhov, another doctor-writer); his own (frightening) experience as a patient; the patient who demanded a hug; and emergency medicine during COVID-19. These stories often end without closure or solutions. The patients are discharged into the world. But if they're lucky, the doctor has listened to their stories as well as treated them.
An enhanced CNN-LSTM remaining useful life prediction model for aircraft engine with attention mechanism
Authors: Li Hao , Wang Zhuojian , Li Zhe
Published: August 2022

Remaining useful life (RUL) prediction is one of the key technologies of aircraft prognosis and health management (PHM) which could provide better maintenance decisions. In order to improve the accuracy of aircraft engine RUL prediction under real flight conditions and better meet the needs of PHM system, we put forward an improved CNN-LSTM model based on the convolutional block attention module (CBAM). First, the features of aircraft engine operation data are extracted by multi-layer CNN network, and then the attention mechanism is processed by CBAM in channel and spatial dimensions to find key variables related to RUL. Finally, the hidden relationship between features and service time is learned by LSTM and the predicted RUL is output. Experiments were conducted using C-MPASS dataset. Experimental results indicate that our prediction model has feasibility. Compared with other state-of-the-art methods, the RMSE of our method decreased by 17.4%, and the score of the prediction model was improved by 25.9%.
Gender dimorphic M1 excitability during emotional processing: a transcranial magnetic stimulation study
Authors: Qiu Fanghui , Zhou Yu , Zhang Lanlan , Zhang Jian , Liu Hui
Published: August 2022

Background

It is widely held that emotions prime the body for action. However, the influence of gender on primary motor cortex (M1) excitability during emotional processing is not well explored.

Methods

Using single-pulse transcranial magnetic stimulation (TMS), we stimulated the right or left M1 at 150 ms and 300 ms after emotional stimulation onset (presentation of negative, neutral, and positive pictures to male and female subjects). Motor-evoked potentials (MEPs) ratio induced by single-pulse TMS was used to assess changes in corticospinal excitability.

Results

In response to right M1 stimulation, males demonstrated higher MEP ratios following presentation of negative pictures at 150 ms while MEP ratios in response to presentation of positive pictures were greater at 300 ms. Furthermore, male subjects showed larger MEP ratios in right M1 versus left M1 at 300 ms after initiation of positive pictures, indicating lateralization of motor excitability in male subjects.

Conclusions

The current study thus provides neurophysiological evidence to support gender differences and functional lateralization of motor excitability in response to emotional stimuli.
AN UPDATE ON SUBCLINICAL HYPOTHYROIDISM, COMPLICATIONS, AND ITS MANAGEMENT BY AYURVEDIC MEDICINES: A REVIEW
Authors: Gautam Naveen , Upadhyay Subhash
Published: August 2022

Subclinical hypothyroidism (SCH) is characterized by an average level of tetraiodothyronine (T4) and triiodothyronine (T3) and an uncharacteristic rise of serum thyroid-stimulating hormone (TSH). The occurrence of hypothyroidism is about 4-5% in the developed world and about 4- 15% worldwide, which is increasing at an alarming rate. Mostly, Subclinical hypothyroidism (SCH) has been considered in two main categories based on the elevation in serum thyroid-stimulating hormone (TSH) level. The first category included a mild increase in TSH levels, i.e., 4.0–10.0 mU/l, while the second category involved a more critically increased TSH value, i.e., >10 mU/l. For overt hypothyroidism, treatment is based on symptoms, while subclinical hypothyroidism didn’t follow the same due to the asymptomatic behaviour of the disease. Additionally, subclinical hypothyroidism is associated with cardiovascular diseases, complications during pregnancy and diabetes, etc. In the current review, we mainly discussed the diagnosis of subclinical hypothyroidism, possible complications, management of SCH with ayurvedic remedies, and some Yogasanas preferred in managing the disease.
PHARMACOLOGICAL ACTIVITY OF CONSTITUENTS OF TRIBHUVAN KIRTI RASA: A REVIEW
Authors: Rawat Tarang , Yadav Yadevendra , Sharma Usha , Mitra Shuchi , Sharma Khem Chand
Published: August 2022

Tribhuvan Kirti Rasa is a herbo-mineral preparation mentioned under Jvara chikitsa (Treatment of Fever) in Yogratnakar. It has the potency to cure thirteen types of Jvara (Fever). It comprises five herbal drugs, i.e., Aconitum Ferox Wall ex, Zingiber officinale Rosc, Piper nigrum Linn, Piper longum Linn, the root of Piper longum Linn. and two mineral drugs, i.e., Cinnabar, Borax in equal ratio. Bhavana (Levigation) is given by Ocimum sanctum Linn, Zingiber officinale Linn, and Datura metel Linn. Most of the drugs in Tribhuvan Kirti Rasa possess Katu (pungent)- Tikta (bitter) in Rasa (Taste), Ushna (hotness) in Virya, and Guna (Property) is Laghu (lightness), Ruksha (dryness) and Tikshna (sharpness) and having Ama pachak (digestive) and anti-inflammatory properties as proven by various studies. Thus, this review article helps to understand that Tribhuvan Kirti Rasa can also effectively pacify Jvara (Fever).
A REVIEW ON THE ASSOCIATION OF AAHAR WITH MENTAL HEALTH
Authors: Vaidya Prajakta , Dhurde Smita
Published: August 2022

Nutrition is the gross term. It includes body nourishment and mind nourishment. Mind nourishment can be understood in two forms, i.e. good thoughts and good food. Good thoughts depend on a positive mind attitude. The goodness of food depends on what kind of food a person eats and how to eat the food. The role of Satwik Aahar mentioned in Bhagwat Geeta, Chaturvidh Aahar, and Shad-rasatmak Aahar mentioned in Ayurvedic texts are essential to know what to eat, and Aharvidhi Vidhan, which is explained in Charaka Samhita is necessary to understand how to eat. The mind has three qualities, Satwa, Raja and Tama, which are present in almost everything, including food. Chhandogya Upanishad points out that the food eaten has three layers; sthula amsha, madhyama amsha and sukshma amsha, and what is sukshma (the subtlest part), that is mind. It also states Aahar shuddhau satwa shuddhi. From the purity of food comes the purity of mind. One should always try to increase the Satwa guna because; the persons having Alpa Satwa are more prone to have diseases, as Alpa Satwa indulges Pradnyaparadha, and pradnyaparadha is the root cause of all kinds of illness. So, it is important to achieve Satwa Shuddhi and to achieve Satwa Shuddhi Aahar Shuddhi is important.
UNDERSTANDING ARDHAVABHEDAKA (MIGRAINE) IN AYURVEDA: A REVIEW
Authors: Walunj Sayali Ramdas , Khanolkar Gurunath D , Shukla Deepnarayan V , Madavi Kishorkumar , Meshram Dnyaneshwar
Published: August 2022

Headache is a prevalent annoying symptom in general practice. Migraine is a common type of headache experienced by the general population. It is a chronic debilitating third most prevalent disease. However, Ayurveda is preventive, and curative science postulates that migraine can be cured, or its episodes can be handled well with ayurvedic medications if the samprapti is adequately understood. Ayurvedic texts mentioned the detailed explanation of shirorooja and its treatment protocol. This review article gives an idea about the ayurvedic and the modern concept of the pathophysiology of migraine, summarises the possible causes for the migraine attacks, and treatment to be done based on understanding the systemic causes, i.e., doshavastha also.
PANCHAKARMA PERSPECTIVES FOR THE MANAGEMENT OF OBESITY (STHAULYA): A REVIEW
Authors: Bohra Mohita
Published: August 2022

Acharya Charaka enumerates obese individuals in eight types of condemned (Ashta-ninditiya) individuals in the context of treatment. Overweight and obesity are abnormal or excessive fat accumulation that presents a health risk. Though not considered a disease due to the lack of a universal concomitant group of symptoms or signs and the impairment of functions that characterize disease according to traditional definitions, it holds a competitive threat to human well-being. Where different efforts and treatments prove futile and the need to combat obesity increases, Panchakarma is a very effective and non-invasive treatment modality at best. The different procedures focus on the purification and correction of the metabolism at the molecular level. Various studies have shown immunological and metabolic changes associated with weight loss after the treatment. Panchakarma therapies aim towards not only reduction of body weight but also the correction of digestive fire and eliminate of waste products like free radicals causing various diseases, thus correcting the whole cycle of metabolism and bringing rejuvenation along with the correction of disease.
A CASE STUDY ON AMALAKI SVARASA (PHYLLANTHUS EMBLICA): A POTENTIAL SINGLE DRUG INTERVENTION IN MANAGEMENT OF PRAMEHA (DIABETES MELLITUS)
Authors: Kannan Amulya , N Kavya , BM Niveditha , KP Monica , Bhat Sulochana
Published: August 2022

Diabetes is becoming a major health problem, approaching epidemic proportions. Rich medicinal plants have been recognized and documented in Ayurveda texts in the management of prameha (Diabetes mellitus); one among the most appreciated is Amalaki - Indian gooseberry or Amla, also known as Phyllanthus emblica Linn. (Syn. Emblica officinalis Gaertn.), belonging to the family Euphorbiaceae. Amalaki svarasa (juice of amla) was given for one month to a diabetic patient with high glucose levels and exhibited significant results in decreasing blood glucose levels and significant relief in symptoms like fatigue, burning sensation in feet, giddiness, headache, pain below the knees and excessive thirst. Fasting Blood Sugar before treatment was 375 mg/dl and 281 mg/dl after treatment. Postprandial Blood Sugar was 535 mg/dl and 382 mg/dl after treatment. Though several pharmacological studies and few clinical studies have already been done regarding diabetes prevention with this drug, there is still enough scope for re-validating its therapeutic application with its authentic Ayurveda indications and comprehensions.
AYURVEDIC MANAGEMENT OF IRRITABLE BOWEL SYNDROME INDUCED PARIKARTIKA (FISSURE-IN ANO): A CASE REPORT
Authors: A Aisewariya , Reddy Vasudeva , Patel Anita , . .
Published: August 2022

Background: Irritable Bowel Syndrome is a gastrointestinal motility disorder characterized by abdominal pain or discomfort associated with altered defecation or a change in bowel habits, constipation, and abdominal bloating. In Irritable Bowel Syndrome, predominantly diarrhoea type due to repeated elimination, the patient may develop Parikartika. Parikartika is one of the common anorectal anomalies observed in clinical practice. As per the description of signs and symptoms, Parikartika can be co-related to fissure-in ano in modern contexts. The treatment in current clinical practice shows significant recurrence and is mainly indicated for surgery. Rationale of the case report: Here is a case report of 72 years; the male patient is a known case of irritable bowel syndrome predominantly diarrhoea type which got lead to the formation of Fissure-in ano, treatment concentrates both on irritable bowel syndrome and Parikartika since both occur due to vitiation of Vata. Intervention: The patient was given internal medication with Triphala churna avagaha and Jatyadi Ghritha pichu over the anus. Result and outcome: The patient got a satisfactory result within 14 days of Ayurveda treatment. After completion of 21 days course of treatment, surgery was prorogued as the patient improved.
ROLE OF TILATAILA (SESAMUM INDICUM LINN.) MATRABASTI AND YONIPICHU IN NORMAL VAGINAL DELIVERY: A CASE STUDY
Authors: Malsariya Swati , Bharathi K , Pushpalatha B
Published: August 2022

Pregnancy and delivery of the baby are normal physiological processes; they have also been considered emergency conditions because, at any time, they can terminate into a severe hazard. To prevent emergencies, Ayurveda mentioned month-wise management, i.e., Garbhini Parichariya; this was also incorporated with the management of pregnant women until delivery. The ninth-month regimen especially focuses on facilitating the way of delivery. Acharya Charaka prescribed Anuvasana Basti and Yonipichu with Madhura oushadha Siddha taila during the ninth-month regimen for achieving at last goal of Sukhaprasava. In the present study, a 31-year-old primigravida patient was selected, she was given Matrabasti and Yonipichu with Tila taila after 35th weeks of gestation till delivery, and she was assessed during labour to document the duration of different stages of labour through Partogram and Bishop’s score. The patient delivered a live healthy female child at the gestation age of 40 weeks four days. The condition of the newborn was assessed by APGAR score and birth weight. Tila taila was used for the study as Tila (sesame) is considered under madhura drugs as it has madhura rasa and madhura vipaka; it is readily available and extensively consumed. Hence, the current study established its effect on the labour process.
ROLE OF MAHAMANJISHTADI KWATH WITH LOCAL APPLICATION OF KESAR AND HARIDRA IN MUKHADUSHIKA WITH SPECIAL REFERENCE TO ACNE VULGARIS: A CASE STUDY
Authors: Mishra Madhuri , Diwekar Ujwala , Dhurde Smita V
Published: August 2022

Acne vulgaris is a disease of the pilosebaceous follicle characterized by noninflammatory (open and closed comedowns) and inflammatory lesions (papules, pustules, and nodules)1. Four major factors are involved in the disease production: increased sebum production, cornification of pilosebaceous ducts, microbial involvement, and inflammation. This condition is commonly found in puberty2. In Ayurveda, it is termed Mukhadushika. In Ayurveda, Mukhadushika is described under the heading of Kshudrarogas. The Shalmali thorn-like eruption on the face due to vitiation of Kapha, Vata and Rakta, which are found on the face of adolescents, are called Mukhadushika or YuvanPidika. Although Vata, Kapha and Rakta are mentioned as dosha-du?ya involved in the pathogenesis of the disease, pittaja symptoms are also found in diseases like daha and paka. The patient has been suffering from Acne over the face (Pidika), Burning sensation over the face (Daha), Itching over the face (Kandu), and Discoloration of skin (Vaivarnya) for six months. The patient was treated with local application of Haridra and Kesar to face and Mahamanjishtadi kwath internally. This article shows Mahamanjishtadi kadha internally and kesar and haridra locally in a patient of Mukhadushika shows positive results.
GARBHOPAGHATAKARA BHAVA, PRECONCEPTIONAL RISK FACTORS FOR AUTISM: A CROSS-SECTIONAL SURVEY
Authors: Kulkarni Reena , Simha Sameera , C Srilakshmi
Published: August 2022

Background: Garbhopaghatakara bhava, inclusive of altered maternal habits, diet, behaviours, and exposures in the perinatal period disrupt normal growth and development of the foetus. Autism spectrum disorders (ASD) are characterized by impaired social behaviour and communication skills. Many risk factors for ASD are identified but with no generalization of definite aetiology. Psychosocial anomalies in Ayurveda have been explained under the spectrum of unmada. Such diseases are said to present early in life and persist throughout the lifespan when associated with garbhopaghatakara bhava. This study explores the association of garbhopaghatakara bhava with the etiopathogenesis of ASD. Materials and Methods: Parents of 50 children who have ASD enquired about garbhopaghatakara bhava using a structured survey format. Results: Male preponderance (80%) with middle socio-economic strata (62%) predominated the study population. 48% had delayed speech and communication with poor eye contact, and 24% with delay in gross motor milestones. Garbhopaghatakara bhava leading to ashaya dushti (structural and functional variation in uterine milieu) were secondary to abortions (22%), hypothyroidism (10%), advanced parental age (64%), diabetes mellitus (8%). Amongst diet and activities in the mother, madhura- katu rasa (22%), eating less (28%), frequent meals (28%), day sleep (42%), night wakening (54%), excess travel (18%) and withhold of urges (16%) were seen. The genetic risk was sporadic (14%). Discussion: Garbhopaghatakara bhava can act by changing the epigenetics or disturbing the nutrition, psyche, and intellectual faculties in the child. Conclusion: Baseline information about the association of garbhopaghatakara bhava with ASD was identified. However, further analytical studies can provide substantial information and evidence.
ANTI-INFLAMMATORY EFFECTS OF SIMHASYADI KASHAYA AND GHANAVATI
Authors: S Renju
Published: August 2022

Simhasyadi kashaya mentioned in Chakradatta contains Guduchi, Vasa and Brihati, which are readily available in our surrounding area. It is indicated for Shopha, Swasa, Kasa, Jwara and Chardi. In contrast, Simhasyadi Ghanavati is taken on the hypothesis that Ghanavati is more effective than kwatha. Apart from these, vatis are more durable, and medicinal value can be maintained for a more extended period, easy to administer and easy to store. In the present study, Simhasyadi Kashaya and ghanavati were prepared by standardised methods and tested in albino rats for anti-inflammatory action. The rats of either sex weighing 150 to 250 gm are used in this experiment. The control rats receive 1 ml of distilled water; the standard group is given ibuprofen suspension, test group A given oral administration of Simhasyadi kwatha and test group B given Simhasyadi ghanavati orally. After 1 hour, the rats are injected with 0.05 ml of 1% carrageenan solution subcutaneously into the plantar side of the left hind paw. The paw is marked with ink at the level of the lateral malleolus and immersed in mercury up to this mark. The paw volume is measured plethysmographically immediately after injection and again after 30 min, 60 min, 120 min, 180 min and after 12 hours and eventually 24 hours after challenge. The statistical tests proved that the trial drugs, Simhasyadi kashaya and Ghanavati, had a significant anti-inflammatory effect compared to the control and standard groups. It maintained a constant lower than the control level because of its residual anti-inflammatory action.
DESIGN AND CHARACTERIZATION OF NATEGLINIDE ORAL DISPERSIBLE TABLETS BY SOLID DISPERSION TECHNIQUE
Authors: Reddy P Srikanth , Alagarsamy V , Bose P Subhash Chandra , Sruthi V , Saritha D
Published: August 2022

An ideal dosage regimen in the drug therapy of any disease is the one which immediately attains the desired therapeutic concentration of drug in plasma and maintains it constant for the entire duration of treatment. The main objective of the present work is to investigate the possibility of obtaining an immediate release tablet of Nateglinide with improved dissolution using the Solid dispersion technique. Solid dispersions preparations containing different weight ratios of Nateglinide in PEG6000 (1:1, 1:3, 1:5) were prepared by the melting method and characterized for drug content, phase solubility study, and dissolution study. Immediate release tablets were prepared using various polymers, and the prepared tablets were evaluated for weight variation, friability, assay, hardness, thickness, disintegration test and dissolution test. The Nateglinide immediate release tablet (F2) showed 58.72% drug release within the first 5 min. and 99.50% drug release within 30 min. The results showed that the formulation satisfied the objective of fast disintegration, dissolution, % friability, hardness, wetting time, water absorption ratio, ease of administration and safety. The success of the present study recommends a detailed investigation into in-vivo studies for its effective use in clinical practice.
DEVELOPMENT AND EVALUATION OF HERBAL ANTI-INFLAMMATORY CREAM CONTAINING TURMERIC
Authors: Niyanta Sailor , Ritesh Patel , Umang Gajjar , Bhupendra Prajapati
Published: August 2022

Curcuma longa, also known as turmeric, is a Zingiberaceae plant whose rhizomes are used to make the spice. Curcumin is well known for its anti-inflammatory qualities and skin-protective characteristics. Curcumin has long been used to treat skin infections and inflammation in natural herbal medicines. The purpose of this project is to formulate a turmeric-based anti-inflammatory cream. The herbal cream was created utilizing the primary emulsion method. Different physiochemical tests were performed on the turmeric cream, including drug content, spreadability, viscosity, appearance, homogeneity, grittiness, viscosity, pH measurement, and anti-inflammatory action. The study's findings of various physicochemical properties were determined to be satisfactory and consistent with the commercially available turmeric cream. The data was acceptable and in line with the commercial product.
ADVANCES IN SURGICAL TRACHEOSTOMY AND KANTHGAT VYADHI: A REVIEW
Authors: Mule Chandrashekahar N , Chavan Swapnil K
Published: August 2022

The medical field has undergone many new updates according to the needs of patients and disease conditions. Previously Surgical Tracheostomy was done for Airway Obstruction and Prolonged Ventilation needs. Surgical Tracheostomy has some benefits and some complications. So, according to risk Vs benefits, modern science has developed new techniques to approach the procedure. Thus, they started with a new technique - Percutaneous dilatational tracheostomy (PDT). Tracheostomy is the procedure performed when the patient is on a long-duration ventilator or has Airway Obstruction. Also, Tracheostomy is done for Tracheal toileting when the patient has increased secretion in the trachea and lungs. But now, a day’s advanced tracheostomy is done in emergency services. Considering the risk of Bleeding in surgical tracheostomy, a new technique of surgical tracheostomy has been developed, which doesn’t need cauterization; it has minimum bleeding risk and is a fast procedure with an easy technique. This article overviews Percutaneous Dilatational Tracheostomy and its application in Kanthagat Vyadhi.
STHAULYA, AMA, AND MEDA DHATU, THE DYSFUNCTIONAL NUTRITIONAL METABOLISM WITH SPECIAL REFERENCE TO OXIDATIVE STRESS: A NARRATIVE REVIEW
Authors: Aku Amulya Murthy , Patil Ashok , Sabnis Mukund
Published: August 2022

Obesity and its accompanying consequences are increasingly linked to oxidative stress, as evidenced by a growing body of research. Several biochemical pathways, including superoxide production from NADPH oxidases and glyceraldehyde auto-oxidation, can cause systemic oxidative stress in obese individuals. Hyperleptinemia, inadequate antioxidant defence, chronic inflammation, and postprandial reactive oxygen species production contribute to oxidative stress. This Oxidative stress is related to or co-related to “Ama”. Ama is generated by improper or insufficient digestion of food particles due to a lack of Jatharagni and Mala accumulation in the body. Modern physiology has linked Ama to potentially harmful Free radicals. It is essential to neutralize free radicals because they have one or more unpaired electrons. Oxygen-free radicals, or "Reactive Oxygen Species," make up most dangerous free radicals. Ama is in the same boat as Avipakam (incompletely metabolized) due to its metabolism. This Ama brings on many diseases. Many diseases have been linked to free radicals.
AN ETIOPATHOLOGICAL REVIEW OF SANDHIGATA VATA
Authors: Singh Archana , Khuje Sanjeev , Dwivedi Ashutosh
Published: August 2022

Ayurveda considered Vata the most important Dosha because of its dominance in the function and is supposed to be the frontrunner of the remaining two Doshas. In Brihat-trayi, Acharyas describe Vatavyadhi in a separate chapter, proving its distinct place regarding various diseases. Acharya stated that when the Vata remains Avyahat (without obstruction), Sthanasth (situated in its sites) and Prakritasth (in its balanced state), the person lives happily to the age of 100 years. But when it gets vitiated, it travels along the whole body, gets situated at particular sites, and produces manifestations according to the Nidans and site of accumulation. This concept is known as Gatatva of Vata, and the adjective of that site names the conditions. Sandhigata Vata is one of them and can be correlated with various joint disorders in modern science. This review article presents a detailed study of the etiological aspect of Sandhigata Vata with an Ayurveda perspective to understand its pathogenesis and treat it appropriately.
A REVIEW ON LAGHUKHADIRA VATIKA: AN AYURVEDIC FORMULATION FOR ORAL DISEASES
Authors: Sharma Usha , . Sangita , Mitra Shuchi , Yadav Yadevendra , Sharma Khem Chand
Published: August 2022

Oral diseases are the most common non-communicable diseases (NCDs) and affect people in all age groups throughout their lifetime, causing pain, discomfort, and chronic systemic disease. In Ayurveda, 65 number of Mukharoga (oral diseases) have seven anatomic positions-eight on the lips, 15 on the alveolar margin, eight in connection with the teeth, five on the tongue, nine on the palate, 17 in the oropharynx and three in a whole mouth described by Acharya Sushruta. and Acharya Vagbhata mentioned 75 types of Mukharoga (oral diseases) in 8 sites one extra- Ganda roga (diseases of a face). However, primarily teeth and gums diseases are closely associated with Shotha and Sula (inflammation and pain). Shitada and Upkusha are the diseases of Dantamula (gums) having foul smell, a cardinal clinical feature. Laghukhadira Vatika (LKV) is a polyherbal ayurvedic medicine mentioned for treating oral diseases by acharya Chakrapani Datta for the first time, then the same followed by other authors with different names of the same formulation and their disease indications and applications. It consists of Acacia catechu Willd and Cinnamomum camphor Nees. and Eberm, Myristica fragrans Houtt., Areca catechu Linn. and Piper cubeba Linn. F., Different fractions of extracts of each drug and isolated phytochemicals have potent Krmighna (anti-bacterial), astringent, and Shothahar (anti-inflammatory) activities, as proven by many studies. It is generally used for Mouth ulcers, Pharyngitis (Sore throat), Halitosis and other diseases of teeth, gums, and sore throat, etc. The present survey is aimed to determine the Laghukhadira Vatika against oral diseases.
A REVIEW ON GUNA SIDDHANTA: AN INSIGHT INTO UNDERSTANDING DOSHOPAKRAMANIYA
Authors: . Chaitra , PH Shrikanth , A Arhanth Kumar
Published: August 2022

Guna is one among the Karana Dravya mentioned and shares an inseparable relation with the Dravya. The basis of treatment lies in the principle of Tridosha, which is again attributed to certain Guna. Hence Guna plays a vital role in combating Dosha Guna with Guna found in adopted treatments. The basics of Samanya Vishesha Siddhanta are dependent on Guna. There is an application of Guna Siddhanta from identifying Dosha Guna to understanding Vyadhi by Amshamsha Kalpana and in treatment planning. But very little literary work is done to determine the same. The present article tries to understand Guna Siddhanta and these three levels. Literature regarding Guna and its grammatical meaning is derived from Sanskrit dictionaries. Dosha Guna and Dosha Vriddhi Kshaya, Doshopakrama from Brihat Trayees are referred to, and a comparison between Dosha Guna with Doshopakrama is done with regards to an understanding of Vatasyopakrama. Dosha are told to possess certain Guna and any contributing factors towards these Guna cause Vruddhi and vice versa. Vikalpa Samprapti, one among Vyadhi Pratibodka Nidana, identifies the Guna involved in disease manifestation. Doshopakrama can be better practised when Guna Siddhanta behind it is identified. Guna is particularly identified when it resides in Sharira. Vatasyopakrama is best understood under Guna Siddhanta and signifies the essentiality of appreciating Guna Siddhanta in Chikitsa.
Exploration of Cultivation Systems and Marketing Channels in Order to Increase Arabic Coffee Farmers' Income in West Java
Authors: Dasipah Euis , Sondari Nunung , Nataliningsih . , Gantini Tuti , Yusup Acep
Published: August 2022

Coffee is a product that continues to be in demand by the public. Indonesia is one of the coffee-producing countries, with production in 2020 amounting to 744,000 tons. Arabica coffee is the most popular type of coffee. The area of ​​Arabica coffee plantations in West Java reaches 27,757 ha. To find out the optimization strategy for coffee production, it is necessary to conduct an exploratory study related to the cultivation system and marketing channels for Arabica coffee in West Bandung Regency. The research method uses a survey with path analysis. The variables observed were the cultivation system used, the marketing channels used and the performance results of Arabica coffee farmers. The results showed that the variable cultivation system and marketing channels affect the productivity and profits of farmers with the equation Y = 0.417 X1 + 0.465 X2 + €. Partially, the cultivation system and marketing channels have an effect on performance, while correlation analysis shows that there is no correlation between the cultivation system and marketing channels. The strategy conveyed was the improvement of the cultivation system, namely the provision of fertilizers or hormones that stimulate flowering, the use of protective trees, the processing of coffee beans and market information. The suggestion is that there is a need for government involvement in coffee management from upstream to downstream.