bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of Interaction Between Odorant Receptors and Flexible Spike of
SARS CoV-2- Key to Loss of Smell
Authors: Anwar Firoz , Altayeb Hisham , Alhayyani Sultan , Kumar Vikas , Al-Abbasi Fahad A , Ashraf Ghulam Md
Published: June 2022

Background:

The development of a vaccine for SARS-CoV-2 is primarily focused on the
structure of the spike (S) protein. The heavy glycosylation of S with flexible hinges at the stalk
shields from antibody attachment.

Objective:

This study deciphers the flexible nature of hinges responsible for binding the odorant receptor
on neurons responsible for the loss of smell in COVID-19 patients.

Methods:

The 3D structure via EPIK in Maestro, protein docking with ligands via Maestro protein
analysis tool, and molecular dynamic simulation at 30 ns run using DESMOND was prepared.

Results:

The data of the study strongly suggest that strong and stable bond formation results from the
reaction between R:14: Trp and Phe at the residue, targeting the flexible hinges of SARS-CoV-2. The
difference in the conformational structure of the S protein and its binding with the odorant receptor in
COVID-19 is the prime factor for the loss of smell and taste in patients, as supported by the concept of
Antigen (epitope) Antibody interaction by the stable formation of a hydrogen bond among odorant receptor
and the S protein. The flexibility of structural proteins determines the binding potential of antibodies
or other defense proteins produced to participate in the antigen-antibody reaction.

Conclusion:

Molecular and atomic details potentiate the design and screening of small molecules
that can inhibit the fusion at entry level or odorant receptors and potentially be used in the prevention
and treatment of infection, particularly when formulated as nasal drops, paving a new approach
for pharmacologists in the treatment of COVID-19 infection.
Mitophagy and Neuroinflammation: A Compelling Interplay
Authors: Charmpilas Nikolaos , Fang Evandro Fei , Palikaras Konstantinos
Published: June 2022

Mitochondria are the main sites of energy production and a major source of metabolic
stress. Not surprisingly, impairment of mitochondrial homeostasis is strongly associated with the development
and progression of a broad spectrum of human pathologies, including neurodegenerative
disorders. Mitophagy mediates the selective degradation of damaged organelles, thus promoting cellular
viability and tissue integrity. Defective mitophagy triggers cellular senescence and prolonged neuroinflammation,
leading eventually to cell death and brain homeostasis collapse. Here, we survey the
intricate interplay between mitophagy and neuroinflammation, highlighting that mitophagy can be a
focal point for therapeutic interventions to tackle neurodegeneration.
Barriers and Facilitators to Diabetes Self-Management in Pregnant Women with Pre-existing Type 2 Diabetes Mellitus: A Scoping Review
Authors: Phonyiam Ratchanok
Published: June 2022

Background:

Pregnant women with pre-existing type 2 diabetes mellitus (T2DM) are at risk of poor maternal and neonatal health outcomes. Previous systematic reviews on pregnant women with T2DM have focused on physical activity, blood glucose monitoring, and insulin injections.

Objective:

The purpose of this scoping review was to examine the barriers and facilitators to diabetes self-management in pregnant women with pre-existing type 2 diabetes mellitus.

Method:

PubMed, CINAHL, and EMBASE databases were searched using the PRISMA-ScR guidelines. Inclusion criteria included manuscripts written in English and qualitative studies. Consensus statements were excluded. A metasummary was used to identify patterns in barriers and facilitators across studies. A vote-counting method was used to summarize qualitative findings.

Results:

A total of ten qualitative publications were selected. This review suggests four themes describing barriers, including barriers to diabetes self-management in pregnancy, stress related to pregnancy with diabetes, a barrier to access to health care, and sensing a loss of control. The fifth theme described facilitators of diabetes self-management in pregnancy.

Conclusion:

This supports an integrative model of maternity care and culturally relevant practices to overcome critical barriers and optimize key facilitators to enhance diabetes self-management behaviors and improve maternal and neonatal health outcomes.
Barriers to Condom Use among Female Sex Workers: A Systematic Review and Meta-Analysis
Authors: Omidi Tahereh , Oshnouei Sima , Mahdi-Akhgar Masomeh , Mohammadian-Khoshnoud Maryam , Mohammadi Younes
Published: June 2022

Background:

Sex without a condom poses the highest risk of sexually transmitted infections among (STIs) female sex workers (FSWs).

Objectives:

This systematic review and meta-analysis was conducted to summarize the evidence related to barriers to condom use among FSWs.

Methods:

We searched Web of Science, PubMed, and Scopus using keywords, such as “condom use” and “sex worker” and the related synonyms. The pooled effect size was expressed as odds ratios (ORs) with 95% CIs using a random-effects model.

Results:

Of the 5,854 studies obtained in the initial search, 35 with a sample size of 14,218 met the eligibility criteria and were included in the final analysis. Three factors identified in studies, i.e., marital status (OR = 1.15; 95%CI [0.74, 1.50]), alcohol consumption (OR = 1.22; 95%CI [0.84, 1.59]), and STIs knowledge (OR = 1.07; 95%CI [0.54, 1.59]), were not significantly associated with not using condom among FSWs. Also, 7 factors identified in studies, i.e., history of violence (OR = 1.84; 95%CI [1.36, 2.31]), history of sexual abuse (OR = 1.87; 95%CI [1.36, 2.38]), history of STIs (OR = 1.54; 95%CI [1.10, 1.97]), HIV risk perception (OR = 1.81; 95% CI [1.58, 2.05]), knowledge of condom use (OR = 1.53; 95%CI [1.15, 1.91]), drug use (OR = 1.62; 95%CI [1.10, 2.14]), and condom use self-efficacy (OR = 1.75; 95%CI [1.52, 1.98]), were significantly associated with not using condom among FSWs.

Conclusion:

Many factors affect condom use among FSWs. However, in this study, the history of sexual abuse, history of violence, and HIV risk perception were identified as the main barriers to condom use among FSWs.
Cancer Stem Cells and Chemoresistance in Ewing Sarcoma
Authors: dos Santos Rafael Pereira , Roesler Rafael , Gregianin Lauro , Brunetto André T. , da Cunha Jaeger Mariane , Lunardi Brunetto Algemir , de Farias Caroline Brunetto
Published: June 2022

Resistance to chemotherapy poses a major challenge for cancer treatment. Reactivating a stem
cell program resembling that seen in embryonic development can lead cancer cells to acquire a stem-cell
phenotype characterized by expression of stemness genes, pluripotency, high self-renewal ability, and
tumor-initiating capability. These cancer stem cells (CSCs) are usually resistant to anticancer drugs and
are likely involved in treatment failure in many cancer types. Ewing sarcoma (ES) is a pediatric cancer
type typically resulting from a typical genetic alteration affecting bone or soft tissues. Despite advances in
treatment, survival prognostic remains poor for patients with refractory or recurrent disease. Here, we
review the increasing evidence indicating that ES tumors contain a CSC subpopulation expressing stem
cell genes, including BM1, OCT3/4, NANOG, and SOX2, that plays a role in resistance to drug treatment,
and current experimental strategies that successfully counteract chemoresistance mediated by CSCs in
ES.
Label-free Quantitative Proteomic Analysis of Ascorbic Acid-induced
Differentially Expressed Osteoblast-related Proteins in Dental Pulp Stem
Cells from Deciduous and Permanent Teeth
Authors: Zainol Abidin Intan Zarina , Manogaran Thanaletchumi , Abdul Wahab Rohaya Megat , Karsani Saiful Anuar , Yazid Muhammad Dain , Yazid Farinawati , Ariffin Zaidah Zainal , Johari Anis Nabilah , Zainal Ariffin Shahrul Hisham
Published: June 2022

Background:

Proteomic is capable of elucidating complex biological systems through protein
expression, function, and interaction under a particular condition.

Objective:

This study aimed to determine the potential of ascorbic acid alone in inducing differentially
expressed osteoblast-related proteins in dental stem cells via the liquid chromatography-mass spectrometry/
mass spectrometry (LC-MS/MS) approach.

Methods:

The cells were isolated from deciduous (SHED) and permanent teeth (DPSC) and induced with
10 μg/mL of ascorbic acid. Bone mineralisation and osteoblast gene expression were determined using
von Kossa staining and reverse transcriptase-polymerase chain reaction. The label-free protein samples
were harvested on days 7 and 21, followed by protein identification and quantification using LC-MS/MS.
Based on the similar protein expressed throughout treatment and controls for SHED and DPSC, overall
biological processes followed by osteoblast-related protein abundance were determined using the PANTHER
database. STRING database was performed to determine differentially expressed proteins as candidates
for SHED and DPSC during osteoblast development.

Results:

Both cells indicated brownish mineral stain and expression of osteoblast-related genes on day 21.
Overall, a total of 700 proteins were similar among all treatments on days 7 and 21, with 482 proteins
appearing in the PANTHER database. Osteoblast-related protein abundance indicated 31 and 14 proteins
related to SHED and DPSC, respectively. Further analysis by the STRING database identified only 22
and 11 proteins from the respective group. Differential expressed analysis of similar proteins from these
two groups revealed ACTN4 and ACTN1 as proteins involved in both SHED and DPSC. In addition,
three (PSMD11/RPN11, PLS3, and CLIC1) and one (SYNCRIP) protein were differentially expressed
specifically for SHED and DPSC, respectively.

Conclusion:

Proteome differential expression showed that ascorbic acid alone could induce osteoblastrelated
proteins in SHED and DPSC and generate specific differentially expressed protein markers.
Overview of Stem Cell Therapy in Intervertebral Disc Disease: Clinical
Perspective
Authors: Hajiesmailpoor Ayshe , Mohamadi Omid , Farzanegan Gholamreza , Emami Payam , Ghorbani Masoud
Published: June 2022

Intervertebral disc degeneration [IDD] is recognized as an aging process, important and most common pathological condition caused by an imbalance of anabolic and catabolic metabolisms in the intervertebral disc [IVD] and leads to changes in the extracellular matrix [ECM], impaired metabolic regulation of nucleus pulposus [NP], and increased oxidative stress. IDD is mostly associated with pain in the back and neck, which is referred to as a type of disability. Pharmacological and surgical interventions are currently used to treat IDD, but evidence has shown that these interventions do not have the ability to inhibit the progression of IDD and restore IVD function because IVD lack the intrinsic capacity for regeneration. Thus, therapies that rely on a degenerative cell repair mechanism may be a viable alternative strategy. Biological interventions have been assessed by attempting to regenerate IVD by restoring ECM and cellular function. Over the past decade, stem cell-based therapies have been considered and promising results have been obtained in various studies. Given this, we reviewed clinical trials and preliminary studies of biological disc repair with a focus on stem cell therapy-based therapies.
Effects of Growth Factors on the Differentiation of Dental Stem Cells: A
Systematic Review and Meta-analysis (Part I)
Authors: Shamszadeh Sayna , Shirvani Armin , Torabzadeh Hassan , Asgary Saeed
Published: June 2022

Introduction:

To evaluate the biological interaction between dental stem cells (DSCs) and
different growth factors in the field of regenerative endodontics.

Methods:

A systematic search was conducted in the electronic databases up to October 2021. This study
followed the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines.
Ex vivo studies evaluating the biological interactions of DSCs and growth factors were included. The
meta-analysis was performed according to the type of growth factor. The outcomes were cell viability/
proliferation and mineralization. Standardized mean differences (SMDs) were estimated using the
random-effect maximum-likelihood method (P < .05). Additional analysis was performed to find any
potential source of heterogeneity.

Results:

Twenty articles were included in the systematic review; meta-analysis was performed for fibroblast
growth factor-2 (FGF-2) and Transforming growth factor-ß1 (TGF-β1) (n = 5). Results showed that
use of FGF-2 significantly increased cell proliferation on day 1-(SMD = 3.56, P = 0.00), 3-(SMD = 9.04,
P = 0.00), 5-(SMD = 8.37, P = 0.01), and 7 (SMD=8.51, P=0.00) than the control group. TGF-ß1 increased
alkaline phosphatase (ALP) activity more than control only on day 3 (SMD = 3.68, P = 0.02).
TGF-β1 had no significant effect on cell proliferation on days 1 and 3 (P > 0.05) and on ALP activity on
days 5 and 7 (P > 0.05). Meta-regression analysis showed that different covariates (i.e., cell type, passage
number, and growth factors' concentration) could significantly influence the effect sizes at different follow-
ups (P < 0.05).

Conclusion:

Specific growth factors might enhance the proliferation and mineralization of DSCs; however,
the obtained evidence was weak. Due to the high heterogeneity among the included studies, other
growth factors' inhibitory/stimulatory effects on DSCs could not be evaluated.
Anti-Allergic Effects of Quercetin and Quercetin Liposomes in RBL-2H3
Cells
Authors: Zhang Yanhui , Guan Rongfa , Huang Haizhi
Published: June 2022

Background:

Quercetin is a kind of flavonoid with important bioactivities, such as
hypoglycemic, antioxidant, anti-inflammatory, and anti-allergic properties. Although it is
unstable, it is worth exploring how to better exert its anti-allergic effect.

Objective:

The current study aimed to elucidate the anti-allergic effect of quercetin liposomes on
RBL-2H3 cells in vitro.

Methods:

Quercetin liposomes were prepared to improve the anti-allergic activity of quercetin
through a green thin-film dispersion method. We compared the anti-allergic effects of quercetin
and quercetin liposomes in RBL-2H3 cells. The anti-allergic activity of the quercetin liposomes
was evaluated by the level of β-hexosaminidase, histamine, Ca2+, IL-4, IL-8, and MCP-1.

Results:

The results showed that quercetin liposomes could significantly restrain the release of
β-hexosaminidase and histamine, calcium influx, and the expression of inflammatory factors,
whose effect is stronger than quercetin.

Conclusion:

Collectively, our research suggests that the quercetin liposome can be used as a
potential allergy antagonist.
Paisagem Linguística da “zona velha” da cidade do Funchal: considerações históricas e sociolinguísticas
Authors: Pereira Bruna
Published: June 2022

A Paisagem Linguística (PL) tem sido uma temática bastante estudada nos anos recentes, no entanto muitas cidades e países europeus ainda não usufruíram de estudos relevantes no seu ambiente sociocultural. Esta investigação pretende analisar o espectro linguístico da chamada “Zona Velha” do Funchal, a capital da Madeira e a primeira localidade da ilha a ser habitada. A ocupação britânica na Ilha da Madeira a partir do séc. XIX, bem como a forte afluência turística nas zonas baixas junto ao mar, tem tornado a cidade do Funchal um ponto de diversidade cultural e linguística. O impacto da língua inglesa manifesta-se especialmente através dos sinais linguísticos comerciais, da restauração e é também um reflexo da relação previamente estabelecida aquando da ocupação mencionada. Partindo deste princípio, este trabalho irá focar-se nos efeitos dessa realidade através do registo e análise de 216 sinais linguísticos presentes numa das zonas mais emblemáticas da cidade, a chamada “Zona Velha”, localizada na freguesia de Santa Maria Maior, apresentando as diferenças entre os sinais públicos e governamentais e os privados e industriais. A metodologia deste trabalho assenta na abordagem top down e bottom up de Ben-Rafael et al. (2006) em que a presença de sinais linguísticos top down demonstra a influência e ocupação britânica no plano sociopolítico, cultural e económico, e os sinais linguísticos bottom up apontam para o fenómeno turístico.
Dificuldades de leitura de estudantes universitários com TDAH: um estudo da influência da memória de trabalho na compreensão leitora
Authors: Ferrari Neto José , Lopez Estivalet Gustavo , De Albuquerque Almeida Priscilla
Published: June 2022

O Transtorno do Déficit de Atenção com Hiperatividade (TDAH) é um transtorno do neurodesenvolvimento que tem como algumas de suas comorbidades os transtornos de linguagem. No âmbito acadêmico, a queixa mais comum é a dificuldade de compreensão leitora de adultos com este transtorno. Este artigo propõe analisar como se dá o processo de leitura em estudantes universitários com TDAH, conferir se os prejuízos na compreensão leitora são decorrentes do TDAH, investigar a influência da memória de trabalho na compreensão da leitura dos participantes com TDAH e comparar a velocidade do desempenho na tarefa de decisão lexical entre os participantes com TDAH e sem TDAH. Participaram nesse estudo 15 estudantes universitários com diagnóstico de TDAH e 15 estudantes universitários sem o referido transtorno. Os instrumentos utilizados foram: o Cloze, a Tarefa de Atenção Linguística (TAL) e a Versão Computadorizada do Reading Span Test para o Português Brasileiro (VCRST-PB). Os resultados apontaram que a capacidade de memória de trabalho dos participantes com TDAH medida no VCRST-PB foi reduzida e exerceu influência negativa na compreensão leitora, assim como a TAL mostrou uma influência maior do que a VCRST-PB na capacidade de leitura. Isso pode ser justificado devido ao processo de leitura requerer uma maior demanda de sustentação da atenção para a emergência da compreensão do conteúdo lido. Sendo assim, isso é mais custoso para os universitários com TDAH devido as dificuldades que os mesmos apresentam no controle executivo.
EFFECT OF PERINATAL FACTORS ON THE ADIPOCYTOKINE’S LEVEL IN OBESE PATIENTS
Authors: Khyzhnyak Oksana , Sulima T. N. , Cherevko I. G. , Manskaya K. G. , Alekseeva I. I.
Published: June 2022

The adiponectine, leptin and insulin levels in both sex obese patients 11-43 years old were under investigation. Such factor as body mass at birth was considered the main cause of adipocytokine’s alteration and insulin resistance development. It was proved that individuals born with low (< 2499 gr) and high (> 4000 gr) body mass are at risk to have decreased level of adiponectine and increased level of leptin. In turn above mentioned alteration of adipocytokines level may lead to insulin resistance development.
THERAPEUTIC POTENTIAL OF METFORMIN: INFLUENCE ON CARBOHYDRATE METABOLISM AND VASOACTIVE NITRIC OXIDE POOL IN PATIENTS WITH COMORBID PATHOLOGY
Authors: Kovalyova O. M. , Demydenko G. V. , Ambrosova T. M.
Published: June 2022

It studied the metformin action on vasoactive nitric oxide pool in patients with essential hypertension with accompanied type 2 diabetes mellitus. Treatment with metformin during 3 months caused positive influence on vasoactive nitric oxide pool in patients with essential hypertension with accompanied type 2 diabetes mellitus. Pharmacologic effects of metformin connect with increasing of endothelial nitric oxide synthase, decreasing if inducible nitric oxide synthase, glicemic control, diminishing of insulin, glicated hemoglobin and insulin resistance indexes. Metformin as a first choice medicine for the patients with essential hypertension and type 2 diabetes mellitus doesn’t cause and complication that leads to the cancelling of the treatment.
THE STATE OF THE NEUROENDOCRINE REGULATION OF HEART RATE IN CHILDREN WITH BRONCHIAL ASTHMA AND RECURRENT BRONCHITIS
Authors: Lezhenko G. A. , Pashkova E. E.
Published: June 2022

The state of the neuroendocrine regulation of heart rate in children with bronchial asthma and recurrent bronchitis was analysed. It was shown that the hyperleptinemia against the hypoinsulinemia were inherent in children with this conditions. It contributed to activation of the sympathetic nervous system against the depression of adrenal compensatory abilities.
DAILY DYNAMICS IN THE CONCENTRATIONS OF EPINEPHRINE AND NOREPINEPHRINE IN THE BLOOD OF SEXUALLY MATURE YOUNG RABBITS
Authors: Bondarenko L. O. , Gorbach V. T. , Kozak V. A.
Published: June 2022

Young adult male rabbits, which were kept under natural day-night, circadian rhythm identified epinephrine and norepinephrine levels in the morning, with a maximum and minimum at night, daytime and evening rates are intermediate. Found that rabbits in daylight is prevailing hormonal link symphatho-adrenal system, and in the dark is the mediator. It is shown that in rabbits, unlike laboratory rats, circadian rhythm of catecholamine similar to having a place in man. In connection with which rabbits is preferred in experimental studies that involve the symphatho-adrenal system.
EFFECT OF OMEGA-3 POLYUNSATURATED FATTY ACIDS ON CLASSIC AND NOVEL CARDIOVASCULAR RISK FACTORS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS (review and our own results)
Authors: Gorshunska Maryana
Published: June 2022

Review is devoted to the metabolic impact and realization mechanisms of the effect of short and long-time omega-3 polyunsaturated fatty acid supplementation on classic and novel cardiovascular risk parameters, also in type 2 diabetes mellitus.
A 2.5-Year Weight Management Program Using Noom Health: Protocol for a Randomized Controlled Trial
Authors: Sysko Robyn , Bibeau Jessica , Boyar Allison , Costello Kayla , Michaelides Andreas , Mitchell Ellen Siobhan , Susanin Annabel , Hildebrandt Tom
Published: June 2022

Background

Overweight and obesity are serious public health concerns. As the prevalence of excess weight among individuals continues to increase, there is a parallel need for inexpensive, highly accessible, and evidence-based weight loss programs.

Objective

This weight loss trial will aim to examine the efficacy of the Noom weight loss program in comparison to a digital control after a 6-month intervention phase and a 24-month maintenance phase, with assessments continuing for 2 years beyond the intervention (to 30 months—after the baseline). The secondary outcomes include quality of life, psychosocial functioning, sleep quality, physical activity, diet, and health status. This trial will also examine the severity of obesity-related functional impairment, weight loss history, and demographic moderators, along with adherence and self-efficacy as mediators of the outcome.

Methods

A total of 600 participants were randomized in a parallel-group, controlled trial to either Noom Healthy Weight Program (intervention) or Noom Healthy Weight Control (control) for a 6-month intervention. Both intervention and control groups include diet and exercise recommendations, educational content, daily logging capabilities, and daily weigh-in entries. The Noom Healthy Weight Program also includes a coach support for weight loss. Remote follow-up assessments of eating, physical activity, psychosocial factors, app use data, and weight will be conducted at 1, 4, 6, 12, 18, 24, and 30 months after baseline. Weight is measured at each follow-up point during a Zoom call using the participants’ scales.

Results

Enrollment began in March 2021 and the 6-month intervention phase ended in March 2022. Data collection for the final assessment will be completed in March 2024.

Conclusions

This study tests commercially available digital lifestyle interventions for individuals with overweight and obesity seeking weight loss support. Data obtained from the study will evaluate whether the Noom Healthy Weight Control Program can help individuals overcome weight loss, achieve long-term maintenance, adhere to lifestyle changes, and feature use barriers that are present in other traditional weight loss treatments.

Trial Registration

ClinicalTrials.gov NCT04797169; https://clinicaltrials.gov/ct2/show/NCT04797169

International Registered Report Identifier (IRRID)

DERR1-10.2196/37541
Web-Based Co-design in Health Care: Considerations for Renewed Participation (Preprint)
Authors: Mallakin Maryam , Dery Christina , Vaillancourt Samuel , Gupta Sahil , Sellen Katherine
Published: June 2022

UNSTRUCTURED

The COVID-19 pandemic has shifted the work environment to a new reality of remote work and virtual collaboration. This shift has occurred in various work settings with an impact on spaces, approaches, applied techniques, and tools. This has resulted in the broad use of virtual tools in the health care sector to avoid physical encounters and in-person interactions that will likely outlast the COVID-19 pandemic. Developing effective virtual approaches requires the knowledge and skills of using digital technologies collaboratively combined with a deep understanding of the context or contexts in which these approaches may be used. The implementation of virtual health design methods, including web-based co-design, has increased to meet the realities of COVID-19 restrictions and is likely to outlast them. Adapting the use of co-design methodologies to a virtual configuration requires rethinking methods of collaboration and communication, adapting to virtual environments, and creating new methods of engagement and facilitation. With this viewpoint, we reviewed the current work on co-design (in person and web based) to propose techniques for the design, planning, and implementation of web-based co-design. We propose 7 considerations that may enable web-based co-design projects in the health care sector. The key considerations that affect the success of a web-based co-design approach should be considered in the process of planning, developing, and conducting web-based co-design sessions. These include facilitation, collaboration, accessibility and equity, communication, sensemaking, tangible tools and games, and web-based research ethics. We illustrate this work with a case study of co-design for an emergency department discharge tool developed during the pandemic.
Use of electronic patient records and encrypted email patient communication among Swiss chiropractors: a population-based cross-sectional study (Preprint)
Authors: Hincapié Cesar A , Hofstetter Léonie , Lalji Rahim , Korner Longin , Schläppi Mireille C , Leemann Serafin
Published: June 2022

BACKGROUND

The implementation of electronic health information technologies is a key target for healthcare quality improvement. Among Swiss chiropractors, reliable data on the use of electronic heath information technologies and distribution of the health workforce was lacking.

OBJECTIVE

To estimate the prevalence of electronic patient record (EPR) and encrypted email communication use among Swiss chiropractors and describe the geographic distribution of chiropractors in Switzerland.

METHODS

Population-based cross-sectional study of all active practising members of the Swiss Chiropractic Association (ChiroSuisse) between 3 December 2019 and 31 January 2020. We asked about clinician and practice characteristics, EPR use for clinical record keeping, use of encrypted email for patient communication, and information on EPR and encrypted email communication products used. Multivariable logistic regression analyses assessed the association between clinician and practice characteristics and (1) EPR use and (2) encrypted email use.

RESULTS

Among 286 eligible Swiss chiropractors (193 [68%] men; mean age, 51.4 [SD, 11.2] years), 217 (76%) completed the survey (140 [65%] men; mean age 50.7 [11.2] years). The density of chiropractors in Switzerland was 3.3 per 100,000 inhabitants. 47% (95% confidence interval [CI], 40% to 54%) of respondents reported using an EPR in their practice, while 60% (95% CI, 54% to 67%) endorsed using encrypted email technology. Chiropractors aged ≥60 (versus those ≤39) years were 74% less likely to use an EPR system (OR 0.26, 95% CI 0.08 to 0.77), while clinicians from practices with 4 or more chiropractors (versus those from solo practices) were over 5 times more likely to report EPR use (OR 5.6, 2.1 to 16.5). Findings for factors associated with encrypted email use were similar.

CONCLUSIONS

As of January 2020, 286 duly licensed chiropractors were available to provide musculoskeletal healthcare in Switzerland — just under 50% of Swiss chiropractors used an EPR system in clinical practice, while 60% used encrypted email technology. Better implementation of EPR and electronic health information technologies in Swiss chiropractic practice is possible and desirable for the purpose of musculoskeletal healthcare quality improvement.

CLINICALTRIAL

Not applicable.
Participation and Contraceptive Use among Women of Childbearing Age in Daerah Istimewa Yogyakarta Province: Further Analysis from IDHS 2017
Authors: Srihadini Tuffahati Nadhifa , Husna Amiza , Fauziah Lisa Mustafidatul , Yusup Heldi , Mulyani Wiwik Puji , Aryati Seri , Listyaningsih Umi , Giyarsih Sri Rum , Suprayogi Slamet
Published: June 2022

Participation and selection of contraceptive methods may vary by region. It depends on the conditions of the region and the characteristics of the population in the region. Decision- making regarding participation and selection of contraceptive methods is influenced by various factors. Based on this description, this study aims to determine participation and selection of contraceptive use in Daerah Istimewa Yogyakarta Province based on educational level and number of living children owned by women of childbearing age. This research method uses further analysis of the 2017 Indonesian Health Demographic Survey (IDHS) data for the women of the childbearing age section. The analytical method used is a descriptive analysis by use of cross tabulation with IBM SPSS software. The results of the study indicate that higher education does not necessarily have a high percentage of contraceptive use, however, the variable number of children has an influence on the participation of contraceptives by women of childbearing age. We found that women with ≤ 2 children still want to have more children and tend to use less effective methods (short-term contraceptive method), while women with > 2 children use long-term contraceptive methods as a more effective method because they want to limit the number of children.
Community Legal Protection in Obtaining Comprehensive and Quality Health Information and Education
Authors: Budiyanti Rani Tiyas , Ganggi Roro Isyawati Permata , Murni Murni
Published: June 2022

Based on the 7th article Law of the Republic of Indonesia Number 36/2009 on Health, everyone has the right to receive balanced and responsible health information and education. Even so, there are problems that still occur in the community such as unequal access to health information and unequal valid health education, especially in rural and coastal areas. This research aims to describe the government’s responsibility and the solutions that can be done in fulfilling the right to access health information. This research was normative research with a statutory and comparative approach using primary, secondary, and tertiary legal materials. The Indonesian government has a responsibility to fulfill the health information and education right based on the 17th article of Law of the Republic of Indonesia Number 36/2009 on Health. Several strategies can be done such as sector collaboration, building information system support facilities, provision of valid health portals, and allocation of budgeting related to health information and education.
Hasrat Konsumsi Virtual dalam Permainan Daring Mobile Legends: Perspektif Deleuze dan Guattari
Authors: Andreas Rino , Arymami Dian
Published: June 2022

Konsumsi virtual, lekat dengan kehidupan masyarakat yang dimediasi oleh teknologi komunikasi dan informasi digital. Salah satunya dapat dilihat dalam ekosistem permainan daring (game online). Tulisan ini bertujuan untuk mengeksplorasi kompleksitas hasrat konsumsi virtual para pemain Mobile Legend: Bang Bang (MLBB) dari perspektif Deleuze dan Guattari serta memaparkan siasat para pemain MLBB yang berupaya keluar dari nilai-norma yang dimapankan oleh kapitalisme digital abad-21. Penelitian kualitatif ini menggunakan metode etnografi virtual yang menempatkan peneliti dalam aktivitas observasi dan partisipasi aktif di ruang virtual. Berdasarkan observasi dan FGI (focus group interview) peneliti melihat bahwa hasrat konsumsi pemain MLBB berada di tataran mikro dan makro. Mesin hasrat dari perspektif Deleuze dan Guattari menghubungkan individu sekaligus sistem sosial sebagai (machinic assemblage). Hasilnya, hasrat konsumsi pemain MLBB tidak hanya di jelaskan dari relasi pemain dan objek virtual itu sendiri melainkan, juga mencakup jaringan kepentingan kapital yang lebih luas meliputi, pihak penyedia jaringan komunikasi, produsen perangkat mobile, perusahaan energi listrik, maupun perusahan finansial teknologi. Hasrat konsumsi sebagai aliran konstruktif, menghadirkan dinamika pemain yang melakukan deteritorialisasi.  Proses ini meninggalkan garis batas (line of flight) nilai-nilai yang dibangun oleh wilayah kapitalisme digital dengan cara melakukan praktik cheating. Pada gilirannya praktik cheating sebagai materialisasi hasrat “chaos” itu ditangkap kembali melalui proses reteritorialisasi oleh pengembang ke dalam sistem pengawasan kecerdasan buatan (Artificial Intelligence) yakni dengan memberikan hukuman. Memastikan para pemain melakukan konsumsi virtual sesuai dengan tatanan yang berlaku.  Maka, hasrat “chaos” telah dikodekan kembali oleh wilayah industri permainan daring, sehingga mendorong pemain mengeluarkan uangnya untuk membeli barang virtual secara terus menerus.
Saminisme Dalam Sengketa Pembangunan Pabrik Semen: Analisis Semiotik Film Sikep Samin Semen
Authors: Yusuf Mohamad
Published: June 2022

Ketegangan antara masyarakat penolak pabrik semen dengan pemerintah daerah serta perusahaan semen di Pegunungan Kendeng masih terjadi hingga sekarang. Salah satu unsur dari kelompok masyarakat penolak yang memiliki peran sangat signifikan adalah mereka pengikut ajaran Samin atau secara umum dikenal dengan nama Sedulur Sikep. Namun, keikutsertaan mereka menimbulkan pro dan kontra baik dari dalam pengikut ajaran Samin sendiri dan dari luar. Sikap pro dan kontra ini dimanifestasikan dalam bentuk dua film. Dari pihak kontra dengan pabrik semen diwakili oleh film Samin vs Semen (2015) sementara dari pihak pro diwakili oleh film Sikep Samin Semen (2015). Film Sikep Samin Semen mengklaim diri sebagai yang paling berhak mendefinisikan ajaran Samin dan menegasikan pengikut ajaran samin yang ada pada film Samin vs Semen. Penelitian ini bertujuan untuk mengetahui bagaimana film Sikep Samin Semen membentuk makna atas sedulur sikep dalam sengketa pembangunan pabrik semen di Pegunungan Kendeng? Penelitian ini menggunakan pendekatan semiotika dari Roland Barthes guna mendapatkan data dari relasi tanda pada tahap pertama (denotasi) dan relasi tanda pada tahap kedua (konotasi). Guna memperdalam analisis, penelitian ini akan mengelaborasikan konsep mitos dari Roland Barthes (1991) dan konsep representasi dari Stuart Hall (1997). Penelitian ini menemukan sedulur sikep dalam film Sikep Samin Semen merupakan orang-orang pendukung privatisasi ruang dan barang publik yang berakhir pada akumulasi kapital oleh perusahaan semen.
Immune Responses after a Third Dose of mRNA Vaccine Differ in Virus-Naive versus SARS-CoV-2– Recovered Dialysis Patients
Authors: Attias Philippe , Azzaoui Imane , El Karoui Khalil , de La Selle Andréa , Sokal Aurélien , Chappert Pascal , Grimbert Philippe , Fernandez Ignacio , Bouvier Magali , Samson Chloé , Dahmane Djamal , Rieu Philippe , Nizard Patrice , Fourati Slim , Sakhi Hamza , Mahévas Matthieu
Published: June 2022

Background and objectives

After two doses of mRNA vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), patients on dialysis show a defective humoral response, but a third dose could increase anti–SARS-CoV-2 spike IgG titers. Responses could be different in virus-naive and SARS-CoV-2–recovered patients on dialysis. However, characterization of memory B cell response after three doses is lacking.

Design, setting, participants, & measurements

We evaluated the dynamics of antireceptor binding domain IgG titers and antireceptor binding domain memory B cells until 6 months after two and three doses (administered within 6 months after the second dose) of mRNA vaccine in SARS-CoV-2–recovered and virus-naive dialysis populations. Results were analyzed by ordinary one-way ANOVA, the Kruskal–Wallis test, or the Wilcoxon matched-pairs test as appropriate.

Results

In total, 108 individuals (59 patients on dialysis and 49 controls) were included. In virus-naive patients on dialysis, antireceptor binding domain IgG response was quantitatively lower after two doses compared with healthy controls, but IgG titers increased by three-fold after three doses (P=0.008). In SARS-CoV-2–recovered patients on dialysis, antireceptor binding domain IgG titers after two doses were significantly higher compared with virus-naive patients on dialysis but did not significantly increase after a third dose. Regarding memory B cell response, we detected receptor binding domain–specific memory B cells at similar proportions in virus-naive patients on dialysis and vaccinated controls after two doses. Moreover, a strong receptor binding domain–specific memory B cell expansion was observed after the third dose in virus-naive patients on dialysis (5.5-fold; P<0.001). However, in SARS-CoV-2–recovered patients on dialysis, antireceptor binding domain memory B cells remained unchanged after the third dose.

Conclusions

The third dose of mRNA vaccine given within 6 months after the second dose boosts serologic and memory response in virus-naive patients but not in SARS-CoV-2–recovered patients on dialysis.

Clinical Trial registry name and registration number:

COVID-19: SARS-CoV-2 Specific Memory B and T-CD4+ Cells (MEMO-COV2), NCT04402892
Sacralidad femenina: fotohagiografía de la madre Conchita
Authors: Fajardo Tapia David
Published: June 2022

Este trabajo analiza un álbum fotográfico que homenajea a Concepción Acevedo de la Llata, mejor conocida como la madre Conchita, quien fue acusada de ser la autora intelectual del asesinato de Álvaro Obregón. El documento destaca por el uso de la fotografía para reconstruir una vida modélica de la persona retratada. Al igual que las hagiografías, el álbum enfatiza la vida religiosa de Acevedo con la intención de representarla como mártir de la Guerra Cristera. Asimismo, el cuaderno proporciona diversas fotografías que datan de la última década del siglo XIX y finaliza con las fotografías del cadáver de la religiosa, dejando ver el valor devocional que los cristeros le otorgaron a la fotografía y abriendo la posibilidad de considerar las imágenes como reliquias.
visión de la independencia de México
Authors: Escrig Rosa Josep
Published: June 2022

Este texto presenta la transcripción de las Memorias de las ocurrencias del reino de la Nueva España desde la llegada del capitán general don Juan O’Donojú hasta la celebración del Tratado de Córdoba, conservadas en el Centro de Estudios de Historia de México-Carso. El documento es de autoría anónima, aunque fue redactado por uno de los integrantes de la comitiva que acompañaba al capitán general y jefe superior político de Nueva España. Según se da cuenta en el estudio preliminar, resulta de relevancia porque presenta un relato particular de los sucesos que rodearon esos días de 1821, aportando nuevos datos para la comprensión de la independencia mexicana.
Parkinsons Disease Detection Using Machine Learning Algorithm: A Review of Literature
Authors: Ahmed Md. Toukir
Published: June 2022

Abstract: Parkinson's disease (PD), or simply Parkinson's is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. A quantitative analysis of handwriting samples would be valuable as it could supplement and support clinical assessments, help monitor micrographic, and link it to PD. Such an analysis would be especially useful if it could detect subtle yet relevant changes in handwriting morphology, thus enhancing solution of the detection procedure. We can find several works that attempt at dealing with this problem out there, most of them make use of datasets composed by a few subjects only. In this study, we conducted a literature review of studies that applied machine learning models to movement data to diagnose PD published in 2019, using the PubMed and IEEE Xplore databases, to provide a comprehensive overview of data modalities and machine learning methods that have been used in the diagnosis and differential diagnosis of Parkinson's disease. In this research, we investigated their goals, data sources, data kinds, machine learning methodologies, and associated outcomes.
Food Security and Safety in India
Authors: Vennila Dr. R.
Published: June 2022

Abstract Let food be your medicine, instead of your medicine being your food. Hippocrates Food is indeed a way of distributing risks, causing sickness and death, and a means of sustaining and enjoying life. Infections caused by contaminated food are the most common transmissible medical problem in the globe. Food contamination has economic consequences at all levels of society. Disease caused by consuming contaminated food results in the need for care, whether it be institutionalized or self-care, on an individual and group level. Income is missed due to illness, which is extremely difficult on breadwinners. Foodborne disease is the most dangerous side effect, and it can even be fatal. It's also severe, with serious socioeconomic and psychological consequences. Despite an increase in the occurrence of foodborne illness, many public health officials fail to acknowledge the worldwide significance of foodborne illness. Changes that directly influence sanitation and the human environment, on the other hand, will pose a greater threat to food safety. Population ageing, urban sprawl and migration, and mass food production due to population growth and changing dietary patterns are all examples. Both traditional and modern food safety techniques should be improved and implemented properly. Legislative measures should be employed where necessary, but voluntary compliance and education of consumers and professional food handlers should be prioritised. This will be a major undertaking for primary care.
War Field Spying Robot Controlled by Raspberry Pi
Authors: Ramachandran Dr. S.
Published: June 2022

Abstract: The major goal of this design is to deal with delicate scenarios when people are unable to navigate scripts such as darkness, entering tiny spaces, and spotting retiring losers. The robot is an ideal machine for the defense sector, as it will help to reduce mortal life loss while also preventing illegalconditioning. The robot is tone-powered, with a backup installation in case the base station's connectionis lost. Wireless cameras transmit real-time videotape and audio inputs to a base station examiner, which may be viewed, and action taken as needed. With a major view, to increase the amount of safety of the soldiers, if we know the activities of the enemy by maintaining a safety distance with them because, the flexibility of defense and attacking of the soldiers can be increased. It consists of a lock to position the enemy and to guide the missile, and the robotic system will also consists of a metal sensor that detects the metals such as land mines and other explosives that could cost the lives of our soldiers and the system can be controlled remotely. In creating this concept, we wanted to offer our army the ability to locate and land mains safely and attack them without damaging their lives. The project was created an army could locate explosives in the land safely, for increasing the safety of our army men and live to attack the enemies without putting our lives at risk
Credit Card Fraud Detection Using Hybrid Approach of Machine Learning
Authors: Yaqoob Mir Auqib
Published: June 2022

Abstract: The usage of internet banking and credit cards is growing at an exponential rate. As more people use credit cards, online banking, and debit cards, the probability of becoming a victim of fraud of various kinds also increases. In recent times, there have been a number of instances in which users of credit card companies have, as a result of a lack of understanding, given their card information, personal information, and one-time password to an unidentified fraudulent caller. As a direct consequence of this, fraudulent activity will occur on the account. Fraud is a problem for the same reason that it is tough to track down a con artist who used a phone identity sim or made the call that utilized an internet provider: it is difficult to find them. Therefore, in order to detect fraudulent activity, this research makes use of supervised methodologies and algorithms, and the results are quite accurate. Customers lose trust in an organization when it engages in activities that are fraudulent or illegal, which in turn has a huge negative impact on the organization. Additionally, it has an effect on the total income and turnover of the company. The isolation forest technique is used in this study to classify data sets acquired from professional survey firms in order to detect fraud activities.
Certification and Attestation Genuinity Management System
Authors: D R Hari Krishnan
Published: June 2022

Abstract: CAGMS (Certificate and Attestation Management system) is an easy-to-use management system where any organization or individual can issue or receive digitally verifiable certificate for any type of documents / awards / rewards etc. with ease of complexity of system and technology. The system uses modern techs and high-interactive API which makes fit for all sort of organization
Speech Based Emotion Recognition
Authors: Srinidhi Ponnaluri
Published: June 2022

Abstract: In this paper we are exhibiting our Final Year Project which is Speech Emotion Recognition. Today's hot study issue is speech and emotion detection, with the goal of improving human-machine connection. Currently, the majority of research in this field relies on discriminator extraction to classify emotions into several categories. The majority of the present research focuses on the utterance of words that are employed in language-dependent lexical analysis for emotion detection. This study employs strategies to classify emotions into five categories: anger, calm, anxiety, happiness, and sorrow using Machine Learning algorithm Convolutional Neural Network.
Network Anomaly Detection over Streaming Data Using Feature Subset Selection and Ensemble Classifiers
Authors: Taranum Dr. Ayesha
Published: June 2022

Abstract: Anomaly based Intrusion Detection Systems (IDS) handle ordinary and bizarre way of behaving by look at network traffic in various standard datasets. Goading forIDSs is bountiful of information to process, low discovery rates and steep of deceptions. Considering irregularity design discovery as distinguishing a particular momentwhere the way of behaving of the framework is strange andessentially not the same as past way of behaving. Anticipated on the test results accomplished, we infer that the proposed strategy is a proficient technique for network interruption location. Relationship shows that the proposedmodel is proficient than other existing models as for interruption recognition result.