bluuebunny/crossref_metadata_2025 huggingface dataset:
Encephalitis and antibodies to dipeptidyl‐peptidase–like protein‐6, a subunit of Kv4.2 potassium channels
Authors: Boronat Anna , Gelfand Jeffrey M. , Gresa‐Arribas Nuria , Jeong Hyo‐Young , Walsh Michael , Roberts Kirk , Martinez‐Hernandez Eugenia , Rosenfeld Myrna R. , Balice‐Gordon Rita , Graus Francesc , Rudy Bernardo , Dalmau Josep
Published: September 2012

Objective:

To report a novel cell surface autoantigen of encephalitis that is a critical regulatory subunit of the Kv4.2 potassium channels.

Methods:

Four patients with encephalitis of unclear etiology and antibodies with a similar pattern of neuropil brain immunostaining were selected for autoantigen characterization. Techniques included immunoprecipitation, mass spectrometry, cell‐base experiments with Kv4.2 and several dipeptidyl‐peptidase–like protein‐6 (DPPX) plasmid constructs, and comparative brain immunostaining of wild‐type and DPPX‐null mice.

Results:

Immunoprecipitation studies identified DPPX as the target autoantigen. A cell‐based assay confirmed that all 4 patients, but not 210 controls, had DPPX antibodies. Symptoms included agitation, confusion, myoclonus, tremor, and seizures (1 case with prominent startle response). All patients had pleocytosis, and 3 had severe prodromal diarrhea of unknown etiology. Given that DPPX tunes up the Kv4.2 potassium channels (involved in somatodendritic signal integration and attenuation of dendritic back‐propagation of action potentials), we determined the epitope distribution in DPPX, DPP10 (a protein homologous to DPPX), and Kv4.2. Patients' antibodies were found to be specific for DPPX, without reacting with DPP10 or Kv4.2. The unexplained diarrhea led to a demonstration of a robust expression of DPPX in the myenteric plexus, which strongly reacted with patients' antibodies. The course of neuropsychiatric symptoms was prolonged and often associated with relapses during decreasing immunotherapy. Long‐term follow‐up showed substantial improvement in 3 patients (1 was lost to follow‐up).

Interpretation:

Antibodies to DPPX are associated with a protracted encephalitis characterized by central nervous system hyperexcitability (agitation, myoclonus, tremor, seizures), pleocytosis, and frequent diarrhea at symptom onset. The disorder is potentially treatable with immunotherapy. ANN NEUROL 2013.
Extrusion‐based differences in two types of nylon 6 capillary‐channeled polymer (C‐CP) fiber stationary phases as applied to the separation of proteins via ion exchange chromatography
Authors: Schadock‐Hewitt Abby J. , Pittman Jennifer J. , Stevens Kathryn A. , Marcus R. Kenneth
Published: September 2012

Nylon 6 capillary‐channeled polymer (C‐CP) fibers used as the stationary phase in high‐performance liquid chromatography protein separations have been investigated. A difference in chromatographic behavior between two (presumably identical) nylon 6 C‐CP fibers, designated simply as nylon 6A and nylon 6B, reveals unknown differences in their chemical and physical nature as proteins are less retained on the latter. The possible differences are evaluated through several test methods, including Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), mechanical testing, MALDI‐TOF mass spectrometry, an organic reaction with ninhydrin, and dilute solution viscometry. Nylon 6B is shown to be a larger perimeter, stronger fiber, yet in a 200 mm, 0.8 mm i.d. column having an interstitial fraction of ∼0.6, it has an available surface area of ∼189 cm2, while nylon 6A is almost double that at ∼374 cm2. It is revealed that when in amorphous form, the base polymers have very comparable FTIR and DSC characteristics. When in their solid, extruded fiber form there are significant differences found in crystallinity, tensile strength, molecular weight distribution, and end group density. Nylon 6A is a lower molecular weight fiber, which results in ∼1.3× more amine end groups than nylon 6B. It is the end group density that ultimately determines the separation qualities. These results imply that both a difference in base nylon 6 molecular weight and also the fiber extrusion process have a significant influence on the performance of nylon 6 C‐CP fiber separation of proteins via ion exchange chromatography. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
Systemic sclerosis endothelial cells recruit and activate dermal fibroblasts by induction of a connective tissue growth factor (CCN2)/transforming growth factor β–dependent mesenchymal‐to‐mesenchymal transition
Authors: Serratì Simona , Chillà Anastasia , Laurenzana Anna , Margheri Francesca , Giannoni Elisa , Magnelli Lucia , Chiarugi Paola , Dotor Javier , Feijoo Esperanza , Bazzichi Laura , Bombardieri Stefano , Kahaleh Bashar , Fibbi Gabriella , Del Rosso Mario
Published: September 2012

Objective

Clinical evidence suggests that the vascular abnormalities of systemic sclerosis (SSc) precede the onset of fibrosis, but molecular cues accounting for a possible vascular connection of SSc fibrosis have been elusive, although they have been searched for intensively. Since we had previously shown that connective tissue growth factor (CCN2), endowed with fibroblast‐oriented activities, was overexpressed by endothelial cells (ECs) from SSc patients, we undertook this study to investigate its role and mechanisms in fibroblast activation.

Methods

Normal fibroblasts were challenged with conditioned medium of normal microvascular ECs (MVECs) and MVECs obtained from SSc patients with the diffuse form of the disease. Fibroblast invasion was studied using the Boyden chamber Matrigel assay. Fibroblast activation was evaluated by Western blotting and immunofluorescence of α‐smooth muscle actin (α‐SMA), vimentin, and type I collagen. Matrix metalloproteinase (MMP) production was evaluated by zymography and reverse transcription–polymerase chain reaction. Signal transduction and activation of the small GTPases RhoA and Rac1 were studied by Western blotting. Inhibition of SSc MVEC conditioned medium–dependent fibroblast activation was obtained by anti‐CCN2 antibodies and the transforming growth factor β (TGFβ) antagonist peptide p17.

Results

SSc MVEC CCN2 stimulated fibroblast activation and invasion. Such activities depended on CCN2‐induced overexpression of TGFβ and its type I, II, and III receptors combined with overproduction of MMP‐2 and MMP‐9 gelatinases. All of these effects were reversed by the TGFβ antagonist peptide p17. Motility increase required Rac1 activation and RhoA inhibition and was inhibited by an MMP inhibitor. These features connoted a mesenchymal style of cell invasion. Since fibroblast activation also fostered overexpression of α‐SMA, vimentin, and type I collagen, the CCN2‐dependent increase in fibroblast activities recapitulated the characteristics of a mesenchymal‐to‐mesenchymal transition.

Conclusion

SSc MVECs recruit and activate dermal fibroblasts by induction of a CCN2/TGFβ‐dependent mesenchymal‐to‐mesenchymal transition.
Study on the ternary system of MoO42‐–enzyme–PdCl2 by resonance Rayleigh scattering, second‐order scattering and frequency‐doubling scattering spectra and its analytical application
Authors: Wang Yaqiong , Liu Shaopu , Liu Zhongfang , Hu Xiaoli , Xue Jiaxing , Tian Jing
Published: September 2012

In pH 4.0 Britton–Robinson buffer medium, PdCl2 was able to react with enzymes (EZ) such as lysozyme (LYSO) and papain (PAP) to form a coordination complex (EZ–PdCl2), which further reacted with MoO42‐ to form a ternary complex (MoO42‐–EZ–PdCl2). As a result, the absorption and fluorescence spectra changed; new spectra of resonance Rayleigh scattering (RRS), second‐order scattering (SOS) and frequency‐doubling scattering (FDS) appeared and their intensities were enhanced greatly. The maximum RRS, SOS and FDS wavelengths of two ternary complexes were located at 310, 560 and 350 nm, respectively. The increments of scattering intensity were directly proportional to the concentrations of EZ within certain ranges. The detection limits (3σ) of LYSO and PAP were 4.5 and 14.0 ng/mL (RRS method), 9.6 and 57.8 ng/mL (SOS method), and 5.2 and 106.0 ng/mL (FDS method). Taking the MoO42‐–LYSO–PdCl2 system, which was more sensitive, as an example, the effects of coexisting substances were evaluated. The methods showed excellent selectivity. Accordingly, new rapid, convenient, sensitive and selective scattering methods for the determination of LYSO and PAP were proposed and applied to determine LYSO in egg white with satisfactory results. The reaction mechanism and basis of the enhancement of scattering were discussed. Copyright © 2012 John Wiley & Sons, Ltd.
Systematic review and meta-analysis of outcomes following emergency surgery for Clostridium difficile colitis
Authors: Bhangu A , Nepogodiev D , Gupta A , Torrance A , Singh P
Published: September 2012

Background

Only a small proportion of patients with severe Clostridium difficile infection (CDI) undergo emergency surgery, the timing and nature of which is unclear. The aim of this study was to describe the operations performed and to identify factors predictive of death following emergency surgery for CDI.

Methods

A systematic review of published literature was performed for studies comparing survivors and non-survivors of emergency surgery for CDI. Meta-analysis was carried out for 30-day and in-hospital mortality.

Results

Overall 31 studies were included, which presented data on a total of 1433 patients undergoing emergency surgery for CDI. Some 1·1 per cent of all patients with CDI and 29·9 per cent with severe CDI underwent emergency surgery, although rates varied between studies (0·2–7·6 and 2·2–86 per cent respectively). The most commonly performed operation was total colectomy with end ileostomy (89·0 per cent, 1247 of 1401 detailed surgical procedures). When total colectomy with end ileostomy was not performed, reoperation to resect further bowel was needed in 15·9 per cent (20 of 126). Where described, the 30-day mortality rate was 41·3 per cent (160 of 387). Meta-analysis of high-quality studies revealed that the strongest predictors of postoperative death were those relating to preoperative physiological status: preoperative intubation, acute renal failure, multiple organ failure and shock requiring vasopressors.

Conclusion

This systematic review supports total colectomy with end ileostomy as the primary surgical treatment for patients with severe CDI; other surgical procedures are associated with high rates of reoperation and mortality. Less extensive surgery may have a role in selected patients with earlier-stage disease.
Proteome analysis of altered proteins in streptozotocin‐induced diabetic rat kidney using the fluorogenic derivatization–liquid chromatography–tandem mass spectrometry method
Authors: Tsai Pei‐Yun , Chen Shih‐Ming , Chen Hsiang‐Yin , Li Yi‐Chieh , Imai Kazuhiro , Hsu Kuang‐Yang , Lee Jen‐Ai
Published: September 2012

To find new molecular markers for early diagnosis of diabetic nephropathy, we applied fluorogenic derivatization–liquid chromatography–tandem mass spectrometry to identify the differentially expressed proteins in the kidney of control and streptozotocin‐induced diabetic rats. The Sprague–Dawley rats were injected with the sodium citrate buffer or streptozotocin and then killed after 1, 4, 12 and 24 weeks. The results showed that seven proteins were significantly changed after 1 week of injection. Only one protein had significantly changed after 4 weeks of injection. However, after 12 weeks of injection, the number of altered proteins rose to 10. After 24 weeks of injection, 18 proteins had altered significantly. Five common proteins were significantly altered at week 12 and 24 after injection, respectively. Importantly, these proteins appeared prior to microalbuminuria and may serve as new biomarkers that are able to improve early detection of and new drug development for diabetic‐related nephropathy. Copyright © 2012 John Wiley & Sons, Ltd.
The use of a new, modified Dittmer–Lester spray reagent for phospholipid determination by the TLC image analysis technique
Authors: Dyńska‐Kukulska Katarzyna , Ciesielski Witold , Zakrzewski Robert
Published: September 2012

A new phospholipid‐specific spray reagent is described. A new phospholipid‐specific spray reagent, which is a modification of the Dittmer–Lester reagent, is described in authors' studies. The difference between these two reagents is in the addition of tin (II) chloride to the proposed spray reagent. The use of the described spray reagent together with an image analysis technique allows not only for qualitative, but also for quantitative, determination of major phospholipid classes. Separation of phosphatidylserine (PS), phosphatidylethanolamine (PE) and phosphatidylcholine (PC) was conducted on an HPTLC plate with a mixture of chloroform, methanol and 25% ammonia solution in a volume ratio of 65:25:4 as mobile phase. The calibration curves were linear in the ranges of 5.0–25.0, 1.5–15.0 and 1.0–20.0 µg/spot for PC, PS and PE, respectively. The use of the new spray reagent resulted also in lower limits of detection than the standard molybdenum method for the investigated phospholipids. The proposed method was used to determine the amount of PS in the dietary supplement ‘Session’, and of PS, PE and PC in biological samples, with good results. Copyright © 2012 John Wiley & Sons, Ltd.
ISO 26000 and the Standardization of Strategic Management Processes for Sustainability and Corporate Social Responsibility
Authors: Hahn Rüdiger
Published: September 2012

The standard ISO 26000 aims to provide guidance on social responsibility and help all types of organizations contribute to sustainable development. Such guidance is important since there is still no consistent understanding of what corporate sustainability and social responsibility (CSSR) encompass. Many companies lack a strategic approach to CSSR and instead follow unsystematic procedures; thus, formal strategic planning could improve operational efficiency.

Against this background, this article critically examines the contribution of ISO 26000 to the strategic management processes of different types of companies. This allows the potential of ISO 26000 for guiding companies on their path to sustainability to be identified. The analysis shows that the standard is most useful for beginners in CSSR. However, ISO 26000 does not cover the entire range of strategic management processes. Instead, the standard is especially helpful for internal and external analyses and in providing starting points for implementing sustainability strategies. Copyright © 2012 John Wiley & Sons, Ltd and ERP Environment.
Fibrous Supramolecular Hemoprotein Assemblies Connected with Synthetic Heme Dimer and Apohemoprotein Dimer
Authors: Onoda Akira , Takahashi Akinori , Oohora Koji , Onuma Yoshitaka , Hayashi Takashi
Published: September 2012

Supramolecular hemoprotein assemblies via hemeheme pocket interaction were prepared by synthetic heme dimers containing a linker with charged amino acids and apohemoprotein disulfide dimers. The mixture of the negatively charged heme dimer and the apomyoglobin dimer provides heterotropic fibrous hemoprotein assemblies, which were characterized by size‐exclusion chromatography (SEC) and atomic force microscopy (AFM).
Demetalation of Chlorophyll Pigments
Authors: Saga Yoshitaka , Tamiaki Hitoshi
Published: September 2012

Natural chlorophylls (Chls) and bacteriochlorophyll (BChls), which are major pigments in photosynthesis, possess a central Mg (or Zn) in their cyclic tetrapyrrole macrocycles. Removal of the central metal atom from chlorophyllous pigments, called pheophytinization, is a biologically important reaction in that it allows production of the primary electron acceptors in photosystem II(‐type) reaction centers and is one of the crucial steps in the Chl degradation pathway. Pheophytinization in processed and postharvest foods derived from vegetables and fruits has attracted considerable attention in agricultural and food chemistry from the viewpoints of maintenance of their color level and evaluation by consumers. In this review, we focus on in vivo demetalation reactions and demetalated products of chlorophyllous pigments. In addition, we summarize kinetic studies on in vitro demetalation of natural (B)Chl molecules and their synthetic analogs under acidic conditions.
3‐Fluorotyrosine as a Complementary Probe of Hemoglobin Structure and Dynamics: A 19F‐NMR Study of Synechococcus sp. PCC 7002 GlbN
Authors: Pond Matthew P. , Wenke Belinda B. , Preimesberger Matthew R. , Rice Selena L. , Lecomte Juliette T. J.
Published: September 2012

The hemoglobin from the cyanobacterium Synechococcus sp. PCC 7002 (GlbN) contains three tyrosines (Tyr5, Tyr22, and Tyr53), each of which undergoes a structural rearrangement when the protein binds an exogenous ligand such as cyanide. We explored the use of 3‐fluorotyrosine and 19F‐NMR spectroscopy for the characterization of GlbN. Assignment of 19F resonances in fluorinated GlbN (GlbN*) was achieved with individual Tyr5Phe and Tyr53Phe replacements. We observed marked variations in chemical shift and linewidth reflecting the dependence of structural and dynamic properties on oxidation state, ligation state, and covalent attachment of the heme group. The isoelectronic complexes of ferric GlbN* with cyanide and ferrous GlbN* with carbon monoxide gave contrasting spectra, the latter exhibiting heterogeneity and enhanced internal motions on a microsecond‐to‐millisecond time scale. The strength of the H‐bond network involving Tyr22 (B10) and bound cyanide was tested at high pH. 3‐Fluorotyrosine at position 22 had a pKa value at least 3 units higher than its intrinsic value, 8.5. In addition, evidence was found for long‐range communication among the tyrosine sites. These observations demonstrated the utility of the 3‐fluorotyrosine approach to gain insight in hemoglobin properties.
Native N‐Terminus Nitrophorin 2 from the Kissing Bug: Similarities to and Differences from NP2(D1A)
Authors: Berry Robert E. , Muthu Dhanasekaran , Shokhireva Tatiana K. , Garrett Sarah A. , Zhang Hongjun , Walker F. Ann
Published: September 2012

The first amino acid of mature native nitrophorin 2 is aspartic acid, and when expressed in E. coli, the wild‐type gene of the mature protein retains the methionine‐0, which is produced by translation of the start codon. This form of NP2, (M0)NP2, has been found to have different properties from its D1A mutant, for which the Met0 is cleaved by the methionine aminopeptidase of E. coli (R. E. Berry, T. K. Shokhireva, I. Filippov, M. N. Shokhirev, H. Zhang, F. A. Walker, Biochemistry 2007, 46, 6830). Native N‐terminus nitrophorin 2 ((ΔM0)NP2) has been prepared by employing periplasmic expression of NP2 in E. coli using the pelB leader sequence from Erwinia carotovora, which is present in the pET‐26b expression plasmid (Novagen). This paper details the similarities and differences between the three different N‐terminal forms of nitrophorin 2, (M0)NP2, NP2(D1A), and (ΔM0)NP2. It is found that the NMR spectra of high‐ and low‐spin (ΔM0)NP2 are essentially identical to those of NP2(D1A), but the rate and equilibrium constants for histamine and NO dissociation/association of the two are different.
Directing the Biosynthesis of Putrebactin or Desferrioxamine B in Shewanella putrefaciens through the Upstream Inhibition of Ornithine Decarboxylase
Authors: Soe Cho Z. , Pakchung Amalie A. H. , Codd Rachel
Published: September 2012

To manage iron acquisition in an oxic environment, Shewanella putrefaciens produces the macrocyclic dihydroxamic acid putrebactin (PB) as its native siderophore. In this work, we have established the siderophore profile of S. putrefaciens in cultures augmented with the native PB precursor putrescine and in putrescine‐depleted cultures. Compared to base medium, PB increased by two‐fold in cultures of S. putrefaciens with 10 mM NaCl and 20 mM exogenous putrescine. In cultures augmented with 1,4‐diaminobutan‐2‐one (DAB), PB decreased with only 0.02‐fold PB detectable at 10 mM DAB. As an ornithine decarboxylase (ODC) inhibitor, DAB depleted levels of endogenous putrescine which attenuated downstream PB assembly. Under putrescine‐depleted conditions, S. putrefaciens produced as its replacement siderophore the cadaverine‐based desferrioxamine B (DFO‐B), as characterised by ESI‐MS of the FeIII‐loaded form (m/zobs 614.13; m/zcalc 614.27). A third siderophore, independent of DAB, was observed in low levels. LC/MS Analysis of the FeIII‐loaded extract gave m/zobs 440.93, which, formulated as a 1 : 1 FeIII complex with a macrocyclic dihydroxamic acid, comprising one putrescine‐ and one cadaverine‐based precursor (m/zcalc 440.14). These results show that the production of native PB or non‐native DFO‐B by S. putrefaciens can be directed though upstream inhibition of ODC. This approach could be used to increase the molecular diversity of siderophores produced by S. putrefaciens and to map alternative diamine‐dependent metabolites.
Unusually High‐Affinity Mg2+ Binding at the AU‐Rich Sequence within the Antiterminator Hairpin of a Mg2+ Riboswitch
Authors: Korth Maximiliane M. T. , Sigel Roland K. O.
Published: September 2012

Mg2+‐Responsive riboswitches represent a fascinating example of bifunctional RNAs that sense Mg2+ ions with high selectivity and autonomously regulate the expression of Mg2+‐transporter proteins. The mechanism of the mgtA riboswitch is scarcely understood, and a detailed structural analysis is called for to study how this RNA can selectively recognize Mg2+ and respond by switching between two alternative stem loop structures. In this work, we investigated the structure and Mg2+‐binding properties of the lower part of the antiterminator loop C from the mgtA riboswitch of Yersinia enterocolitica by solution NMR and report a discrete Mg2+‐binding site embedded in the AU‐rich sequence. At the position of Mg2+ binding, the helical axis exhibits a distinct kink accompanied by a widening of the major groove, which accommodates the Mg2+‐binding pocket. An unusually large overlap between two adenine residues on the opposite strands suggests that the bending may be sequence‐induced by strong stacking interactions, enabling Mg2+ to bind at this so‐far not described metal‐ion binding site.
Structure of Malaria Pigment and Related Propanoate‐Linked Metalloporphyrin Dimers
Authors: Bohle D. Scott , Dodd Erin L. , Stephens Peter W.
Published: September 2012

Malaria pigment, the heme detoxification product of malaria's invasion, digestion, and growth inside mammalian red blood cells, is an insoluble phase of iron(III)protoporphyrin‐IX. Even though its structure was determined in 2000 by powder X‐ray diffraction, significant questions remain about its formation and possible interaction with quinoline antimalarial drugs. A recent structural study, also with X‐ray powder diffraction, has reconfirmed that the material isolated from the parasite is isostructural with its synthetic equivalent. It was recently suggested that other isomers may also be formed and may be present in synthetic samples. In particular, a series of stereoisomers are possible for the arrangement of vinyl groups on the periphery of the dimerized porphyrin rings. In principle, any given dimer can have vinyl groups at the α or β sites, and at γ or δ sites. In this paper, several models are evaluated, both biphasic and homogeneous methyl/vinyl disorder, against several sets of diffraction data, both published and new. We conclude that methyl/vinyl disorder is intrinsic to the system, and that the evidence at hand does not support the existence of any other crystalline isomers in carefully prepared samples of either natural or synthetic samples. Finally, the porphyrinporphyrin interactions are evaluated using Scheidt's indicies for porphyrin π‐stacking, and we find modest to weak π‐interactions in these condensed phases.
Total sialic acid profile in regressing and remodelling organs during the metamorphosis of marsh frog (Pelophylax ridibundus Pallas 1771)
Authors: Kaptan Engin , Bas Serap Sancar , Inceli Meliha Sengezer
Published: September 2012

This study aimed to investigate the functional relationship of sialic acid in regressing and remodelling organs such as the tail, small intestine and liver during the metamorphosis of Pelophylax ridibundus. For this purpose, four groups were composed according to developmental periods by considering Gosner's criteria (1964). Our findings showed that the sialic acid content of the larval tail has an opposite profile to cell death process. Although the sialic acid content of the small intestine and liver did not change evidently during metamorphosis, it increased after the completion of metamorphosis. Frog tail extensively exhibited cell death process and decreased proliferative activity and underwent complete degeneration during metamorphic climax. In spite of increased apoptotic index, a decreased sialic acid level in the tail tissues during climax can be the indication of a death cell removal process. However, the intestine and the liver included both cell death and proliferative process and remodelling in their adult forms. Thus, their sialic acid profiles during metamorphosis were different from the tail's profile. These data show that sialic acid may be an indicator of the presence of some cellular events during metamorphosis and that it can have different roles in the developmental process depending on the organ's fate throughout metamorphosis. Copyright © 2012 John Wiley & Sons, Ltd.
Stent strut breakage using high‐pressure balloons for bifurcation stenting and subsequent percutaneous pulmonary valve replacement using the Edwards Sapien THV
Authors: Violini Roberto , Vairo Ugo , Hijazi Ziyad M.
Published: September 2012

This report describes the use of the Edwards Sapien THV in a patient who had a short regurgitant/stenotic homograft with early bifurcation stenoses of the pulmonary arteries. A 48‐mm AndraStent was positioned in the right pulmonary artery‐homograft jailing the left pulmonary artery (LPA). To have an unobstructed access to the LPA, the stent strut leading to the LPA was broken using high‐pressure balloon. A 23‐mm Edwards Sapien THV was positioned in the stented homograft just proximal to the LPA origin with resolution of the stenosis and regurgitation. © 2012 Wiley Periodicals, Inc.
Coronary artery fistula with a giant aneurysm treated by percutaneous transradial embolization
Authors: Tanabe Yauhiro , Tejima Tamotsu , Sakurada Harumizu
Published: September 2012

Coronary artery fistulas are rare anomalies that are very rarely accompanied by an aneurysm. The minimally invasive method of percutaneous transradial embolization, using a thin guiding catheter, was used to treat a coronary artery fistula with an associated giant aneurysm. This technique, not previously described for this type of application, is presented as a case report. The successful outcome of this procedure demonstrated that transradial coronary interventions are useful for treating coronary artery fistulas with an associated giant aneurysm, especially in patients at high risk for conventional surgery or transfemoral interventions. © 2012 Wiley Periodicals, Inc.
ChemInform Abstract: Crystal Structure and Magnetic Properties of Novel R3Co2.2Si1.8 Compounds (R: Y, Gd—Tm).
Authors: Morozkin A. V. , Yao Jinlei , Mozharivskyj Y.
Published: September 2012

The new compound Dy3Co2.2Si1.8 and the other title phases are synthesized by arc‐melting of stoichiometric mixtures of the elements followed by annealing at 1070 K for 120 h in argon atmosphere.
ChemInform Abstract: Multiple Cation and Anion Substitutions into the Structures of Bi2WO6 and PbBi3WO8Cl.
Authors: Charkin Dmitri O. , Lebedev Dmitri N. , Kazakov Sergey M.
Published: September 2012

Simultaneous substitution of W by U and Bi3+ by La3+ in the title compounds leads to the new compound Bi1.5La0.5UO6 and several new solid solutions, which are characterized by powder XRD and Raman spectroscopy.
ChemInform Abstract: Surprising Acid/Base and Ion‐Sequestration Chemistry of Sn94‐: HSn93‐, Ni@HSn93‐, and the Sn93‐ Ion Revisited.
Authors: Kocak F. Sanem , Downing Domonique O. , Zavalij Peter , Lam Yiu‐Fai , Vedernikov Andrei N. , Eichhorn Bryan
Published: September 2012

K4Sn9 dissolves in en to give equilibrium mixtures of the diamagnetic HSn93‐ ion along with KxSn9(4‐x)‐ ion pairs (x = 0, 1, 2, 3).
ChemInform Abstract: α‐MnO2 Nanotubes: High Surface Area and Enhanced Lithium Battery Properties.
Authors: Li Lihong , Nan Caiyun , Lu Jun , Peng Qing , Li Yadong
Published: September 2012

The title nanotubes are hydrothermally prepared from a mixture of KMnO4, NH4H2PO4, Bu4NOH, and H2O (autoclave, 180 °C, 48 h).
ChemInform Abstract: Simple Replacement Reaction for the Preparation of Ternary Fe1‐xPtRux Nanocrystals with Superior Catalytic Activity in Methanol Oxidation Reaction.
Authors: Wang Di‐Yan , Chou Hung‐Lung , Lin Yen‐Chen , Lai Feng‐Ju , Chen Ching‐Hsiang , Lee Jyh‐Fu , Hwang Bing‐Joe , Chen Chia‐Chun
Published: September 2012

Fe1‐xPtRux (x = 25, 29, 43) nanocrystals are prepared from mixtures of FePt nanocrystals (obtained from Pt(acac)2 and Fe(CO)5 in a mixture of 1,2‐hexadecanediol, dioctyl ether, oleylamine, and oleic acid at 300 °C for 30 min) in toluene and RuCl3 in EtOH (85 °C, 3, 10, or 15 h).
ChemInform Abstract: Synthesis, Characterization and Application of Some Nanosized Mixed Metal Oxides as High Heat Resistant Pigments: Ca2CuO3, Ca3Co2O6, and NiSb2O6.
Authors: Fouad Osama A. , Hassan Ali M. , Abd El‐Wahab Hamada , Eldin Adel Mohy , Naser Abdel‐Rahman M. , Wahba Osama A. G.
Published: September 2012

Ca2CuO3 and Ca3Co2O6 are synthesized by coprecipitation using (NH4)2CO3 from solutions of CaCO3 and CuCO3 or CoCO3 followed by firing of the obtained precipitates at 900 °C.
ChemInform Abstract: Carbenylative Amination with N‐Tosylhydrazones.
Authors: Khanna Avinash , Maung Charles , Johnson Kyle R. , Luong Tom T. , Van Vranken David L.
Published: September 2012

The title reaction allows access to pyrrolidine and piperidine ring systems.
ChemInform Abstract: Ionic Liquid Promoted Oxidant‐Free Dehydrogenation of Alcohols with Water‐Soluble Ruthenium Nanoparticles in Aqueous Phase.
Authors: Feng Bo , Chen Chen , Yang Hanmin , Zhao Xiuge , Hua Li , Yu Yinyin , Cao Ting , Shi Yu , Hou Zhenshan
Published: September 2012

A wide range of aromatic and allylic alcohols is effectively oxidized under optimized conditions to aldehydes or ketones.
ChemInform Abstract: Highly Enantioselective Epoxidation Catalyzed by Cinchona Thioureas: Synthesis of Functionalized Terminal Epoxides Bearing a Quaternary Stereogenic Center.
Authors: Russo Alessio , Galdi Gerardina , Croce Gianluca , Lattanzi Alessandra
Published: September 2012

The asymmetric epoxidation of electron‐poor terminal alkenes is efficiently catalyzed by quinine‐derived bifunctional amine—thiourea catalysts.
ChemInform Abstract: Strong Lewis Acids of Air‐Stable Metallocene Bis(perfluorooctanesulfonate)s as High‐Efficiency Catalysts for Carbonyl‐Group Transformation Reactions.
Authors: Qiu Renhua , Xu Xinhua , Peng Lifeng , Zhao Yalei , Li Ningbo , Yin Shuangfeng
Published: September 2012

Cationic mononuclear zirconocene and titanocene perfluorooctanesulfonate complexes are successfully applied in various transformation reactions of carbonyl compounds.
ChemInform Abstract: Palladium‐Catalyzed Conjugate Addition of Terminal Alkynes to Enones.
Authors: Villarino Lara , Garcia‐Fandino Rebeca , Lopez Fernando , Mascarenas Jose L.
Published: September 2012

It provides an efficient method to prepare a number of β‐alkynylated ketones.
ChemInform Abstract: Iron(III)‐Catalyzed Conia—Ene Cyclization of 2‐Alkynic 1,3‐Dicarbonyl Compounds.
Authors: Chan Li Yan , Kim Sunggak , Park Youngchul , Lee Phil Ho
Published: September 2012

FeCl3 and Fe(OTf)3 are found to be efficient for the cyclization of 2‐alkynic dicarbonyl compounds to produce cyclopentene, alkylidenecyclopentane, cyclohexene, and alkylidenecyclohexane derivatives.
ChemInform Abstract: Suzuki—Miyaura Cross‐Coupling of Alkenyl Tosylates with Alkenyl MIDA Boronates.
Authors: Luethy Monique , Taylor Richard J. K.
Published: September 2012

A palladium succinimidoyl complex is found to be an efficient catalyst for the method.
ChemInform Abstract: Synthesis of 4‐Tosyloxy‐2‐substituted Phenols Using New Solid Pyridinium Salt Supported [Hydroxyl(tosyloxy)iodo]benzene Reagents.
Authors: Yang Bing , Zhang Jizhen , Zhao Dejian , Kuang Hua
Published: September 2012

The pyridinium salt can be easily regenerated by MCPBA and Tos‐OH.
ChemInform Abstract: Umpolung Reactions in an Ionic Liquid Catalyzed by Electrogenerated N‐Heterocyclic Carbenes. Synthesis of Saturated Esters from Activated α,β‐Unsaturated Aldehydes.
Authors: Feroci Marta , Chiarotto Isabella , Orsini Monica , Pelagalli Romina , Inesi Achille
Published: September 2012

The first example of the title reaction is presented by using a green and mild methodology.
ChemInform Abstract: Acid‐Promoted Oxygen‐Atom Transfer from a Novel Dihydroisoquinoline‐Derived Oxaziridine Substituted at Position 1.
Authors: Kammoun Majed , Salem Ridha Ben , Damak Mohamed
Published: September 2012

A new isoquinolino‐fused oxaziridine, prepared by MCPBA oxidation of the corresponding imine, is successfully applied as oxygen transfer reagent in the transformation of sulfides (I) to sulfoxides (II).
ChemInform Abstract: Enantioselective Friedel—Crafts Reactions Between Phenols and N‐Tosylaldimines Catalyzed by a Leucine‐Derived Bifunctional Catalyst.
Authors: Li Guo‐Xing , Qu Jin
Published: September 2012

The title reaction between electron‐rich phenols and N‐tosylaldimines is reported.
ChemInform Abstract: Facile Syntheses of Anthra[2,3‐b]chalcogenophenes.
Authors: Niimi Kazuki , Miyazaki Eigo , Osaka Itaru , Takimiya Kazuo
Published: September 2012

The title compounds are prepared in three steps from readily available 3‐bromoanthracen‐2‐ol.
ChemInform Abstract: First Example of the Interaction of Fullerene C60 with Hydrazoic Acid.
Authors: Akhmetov A. R. , Tuktarov A. R. , Dzhemilev U. M. , Yarullin I. R. , Gabidullina L. A.
Published: September 2012

The first one‐pot synthesis of N‐unsubstituted aziridino‐ and triazolinofullerenes is achieved via cycloaddition of fullerene C60 and hydrazoic acid under thermal as well as photochemical reaction conditions.
ChemInform Abstract: Electrochemically Active Cross‐Linking Reaction for Fluorescent Labeling of Aliphatic Alkenes.
Authors: Kim Shokaku , Hirose Kumi , Uematsu Jumpei , Mikami Yuzuru , Chiba Kazuhiro
Published: September 2012

Electrochemical [3 + 2] cyclization of phenolic compounds with various alkenes provides access towards dihydrobenzofuran derivatives as fluorescent probes.
ChemInform Abstract: Ruthenium‐Catalyzed Functionalization of Pyrroles and Indoles with Propargyl Alcohols.
Authors: Thies Nora , Hrib Christian G. , Haak Edgar
Published: September 2012

The outcome of title functionalization reactions is strongly influenced by the nature of propargylic alcohol.
ChemInform Abstract: anti‐Selective Direct Catalytic Asymmetric Aldol Reaction of Thiolactams.
Authors: Sureshkumar Devarajulu , Kawato Yuji , Iwata Mitsutaka , Kumagai Naoya , Shibasaki Masakatsu
Published: September 2012

In the presence of CuMst, the phosphine, and phenol shown in the scheme the thiolactams (I) undergo reaction with a number of aliphatic aldehydes to afford the corresponding aldols with high diastereo‐ and enantioselectivity.
ChemInform Abstract: Synthesis and Application of a Recyclable Ionic Liquid Supported Imidazolidinone Catalyst in Enantioselective 1,3‐Dipolar Cycloaddition.
Authors: Shen Zhi‐Liang , Goh Kau Kiat Kelvin , Wong Cholin Hong An , Loo Wan‐Yi , Yang Yong‐Sheng , Lu Jun , Loh Teck‐Peng
Published: September 2012

The catalyst is prepared in 5 steps and can be reused several times.
ChemInform Abstract: Synthesis of 5‐Substituted 1H‐Tetrazoles Using a Nano ZnO/Co3O4 Catalyst.
Authors: Agawane Sandeep M. , Nagarkar Jayashree M.
Published: September 2012

A new and recyclable catalyst is successfully applied to the general and easy synthesis of the title compounds (II).
ChemInform Abstract: Highly Efficient Enantioselective Three‐Component Synthesis of 2‐Amino‐4H‐chromenes Catalyzed by Chiral Tertiary Amine‐Thioureas.
Authors: Yang Gaosheng , Luo Chongrong , Mu Xiaolong , Wang Tingting , Liu Xin‐Yuan
Published: September 2012

An atom‐economic and straightforward method is used for the preparation of chiral highly functionalized chromenes.
ChemInform Abstract: Tandem Transformations of Nitriles into N‐Heterocyclic Compounds by Electrophilic Trapping of Blaise Reaction Intermediates.
Authors: Kim Ju Hyun , Chun Yu Sung , Shin Hyunik , Lee Sang‐gi
Published: September 2012

Different tandem transformations of Reformatsky reagents to N‐heterocycles.
ChemInform Abstract: Facile Synthesis of 2,5,7‐Trisubstituted Oxazolo[5,4‐d]pyrimidines via Copper‐Catalyzed Intramolecular C—O Bond Formation.
Authors: Xu Dan , Sun Li‐Ping , You Qi‐Dong
Published: September 2012

Key step is an intramolecular C—O cross‐coupling of ortho chloropyrimidine amide via a copper(I)‐mediated cyclization.
ChemInform Abstract: Synthesis of Phenothiazines via Ligand‐Free CuI‐Catalyzed Cascade C—S and C—N Coupling of Aryl ortho‐Dihalides and ortho‐Aminobenzenethiols.
Authors: Dai Chuan , Sun Xiaofei , Tu Xingzhao , Wu Li , Zhan Dan , Zeng Qingle
Published: September 2012

An excellent regioselective synthesis of the title compounds is developed.
ChemInform Abstract: A New Triterpene from Atalantia retusa Merr
Authors: Ragasa Consolacion Y. , Espineli Dinah L. , Mandia Emelina H. , Raga Dennis D. , Don Ming‐Jaw , Shen Chien‐Chang
Published: September 2012

isolation, structure elucidation, cytotoxicity and antimicrobial properties of the new triterpene retusenol (I) and some known compounds, e.g. friedelin and dischidiol
ChemInform Abstract: New Triterpenoid Saponins from Stenocereus eruca.
Authors: Kakuta Kazutaka , Koike Takeshi , Kinoshita Kaoru , Ito Satoru , Koyama Kiyotaka , Takahashi Kunio
Published: September 2012

isolation and structure elucidation of eight new triterpenoid saponins, namely stellatoside C (Ib) and its methyl ester (Ic), stellatoside D (Id), stellatoside E (Ia), stellatoside B methyl ester (Ie), thurberoside A (II), phillyriside A (III) and treleaseside A (IV)
ChemInform Abstract: Convenient One‐Pot Synthesis of Thiosugars and Their Efficient Conversion to Polyoxygenated Cycloalkenes.
Authors: Zhang Jingjing , Niu Youhong , Cao Xiaoping , Ye Xin‐Shan
Published: September 2012

A one‐pot protocol for the synthesis of thiosugars with xylo, ribo, gluco, manno, fuco, and galacto configuration via thioetherification of diols with sodium sulfide is developed.
ChemInform Abstract: New Sphingolipids from Abutilon pakistanicum
Authors: Ali Bakhat , Mehmood Rashad , Hussain Riaz , Malik Abdul , Imran Muhammad , Nawaz Haq , Hussain Ajaz
Published: September 2012

isolation and structure determination of pakistamides A (Ia) and B (Ib)
ChemInform Abstract: Hypercohin A, a New Polycyclic Polyprenylated Acylphloroglucinol Possessing an Unusual Bicyclo[5.3.1]hendecane Core from Hypericum cohaerens.
Authors: Xu Gang , et al. et al.
Published: September 2012

Compound (I) shows moderate inhibitory effects on acetylcholinesterase and moderate cytotoxic activity against several human cancer cell lines in vitro.
ChemInform Abstract: Magnetic Nanochains: A Review
Authors: Wang Hui , Yu Yifei , Sun Yubin , Chen Qianwang
Published: September 2012

Review: 124 refs.
ChemInform Abstract: Carbon as a Hard Template for Nano Material Catalysts
Authors: Zhu Kake , Sun Junming , Zhang He , Liu Jun , Wang Yong
Published: September 2012

Review: 121 refs.
ChemInform Abstract: Synthesis of 2,2′‐Bipyridines by Transition Metal‐Catalyzed Alkyne/Nitrile [2 + 2 + 2] Cycloaddition Reactions
Authors: Okamoto Sentaro
Published: September 2012

Review: 31 refs.
ChemInform Abstract: Streamlining Organic Synthesis for the 21st Century
Authors: Hoffmann R. W.
Published: September 2012

Review: 35 refs.
ChemInform Abstract: The Evans—Tishchenko Reaction: Scope and Applications
Authors: Ralston Kevin J. , Hulme Alison N.
Published: September 2012

Review: ca. 100 refs.
ChemInform Abstract: Electrochemically Induced Chain Reactions in Organic Synthesis
Authors: Ilovaisky A. I. , Merkulova V. M. , Elinson M. N. , Nikishin G. I.
Published: September 2012

Review: 124 refs.
ChemInform Abstract: The Progression of Chiral Anions from Concepts to Applications in Asymmetric Catalysis
Authors: Phipps Robert J. , Hamilton Gregory L. , Toste F. Dean
Published: September 2012

Review: 105 refs.
ChemInform Abstract: Synthesis and Application of Metal Ion Containing Ionic Liquids
Authors: Wang Li‐Juan , Lin Cui‐Hua
Published: September 2012

Review: 29 refs.
ChemInform Abstract: Self‐Assembly Directed by Copper(II) Polyamine Species
Authors: Zhou H. , Pan Z. Q.
Published: September 2012

Review: 75 refs.
ChemInform Abstract: Synthesis of Novel Carbohydrate Mimetics via 1,2‐Oxazines
Authors: Bouche Lea , Reissig Hans‐Ulrich
Published: September 2012

Review: 45 refs.
ChemInform Abstract: The Kondo Lattice Models and Magnetism for Cerium and Uranium Systems
Authors: Coqblin B.
Published: September 2012

Review: 58 refs.
ChemInform Abstract: Understanding the Magnetic, Electronic and Structural Behavior of Technologically Important Magnetic Materials of Current Interest
Authors: Yusuf S. M.
Published: September 2012

Review: 39 refs.
ChemInform Abstract: Protein Conformational Switches: From Nature to Design
Authors: Ha Jeung‐Hoi , Loh Stewart N.
Published: September 2012

Review: 182 refs.
ChemInform Abstract: Biological and Therapeutic Effects of Emblica officinalis and Its Active Constituents
Authors: Farooqi A. H. A. , Kumar V. S. , Abdul‐Khaliq Abdul‐Khaliq
Published: September 2012

Review: 52 refs.
ChemInform Abstract: Role of Co‐crystals in the Pharmaceutical Development Continuum
Authors: Schultheiss Nate , Henck Jan‐Olav
Published: September 2012

Review: 61 refs.
Recycling of Demolishing Wall Material Consisting of Fine Grained Mineral by Agglomeration
Authors: Schindhelm Stefan , Schnell Alexander , Hennig Manuel , Schwieger Barbara , Müller Anette , Teipel Ulrich
Published: September 2012

Steigende Rohstoffpreise machen eine Wiederverwertung von Bau‐ und Abbruchabfällen ökonomisch attraktiv. Jährlich fallen deutschlandweit 50 bis 60 Mio. Tonnen Beton‐ und Mauerwerkbruch an. Durch Zerkleinerung, Formgebung und Erhärtung sollen Leichtgranulate hergestellt werden, die vollständig aus mineralischen Abfällen bestehen. Ein Teilprozess ist hierbei die Formgebung mittels Aufbau‐ oder Pressagglomeration vor der eigentlichen Erhärtung. Es wurden drei Herstellungsvarianten der Agglomeration im Granulierteller, im Intensivmischer und in der Matrizenpresse durchgeführt. Eine ausreichende Transportstabilität wird mit allen drei Verfahren erreicht, jedoch weisen die mittels Intensivmischer bzw. Matrizenpresse hergestellten Grüngranulate eine größere Abriebfestigkeit auf.
Achieving energy efficiency during collective communications
Authors: Sundriyal Vaibhav , Sosonkina Masha , Zhang Zhao
Published: September 2012

Energy consumption has become a major design constraint in modern computing systems. With the advent of petaflops architectures, power‐efficient software stacks have become imperative for scalability. Techniques such as dynamic voltage and frequency scaling (called DVFS) and CPU clock modulation (called throttling) are often used to reduce the power consumption of the compute nodes. To avoid significant performance losses, these techniques should be used judiciously during parallel application execution. For example, its communication phases may be good candidates to apply the DVFS and CPU throttling without incurring a considerable performance loss. They are often considered as indivisible operations although little attention is being devoted to the energy saving potential of their algorithmic steps. In this work, two important collective communication operations, all‐to‐all and allgather, are investigated as to their augmentation with energy saving strategies on the per‐call basis. The experiments prove the viability of such a fine‐grain approach. They also validate a theoretical power consumption estimate for multicore nodes proposed here. While keeping the performance loss low, the obtained energy savings were always significantly higher than those achieved when DVFS or throttling were switched on across the entire application run. Copyright © 2012 John Wiley & Sons, Ltd.
Assessing the quality and trustworthiness of citizen science data
Authors: Hunter Jane , Alabri Abdulmonem , van Ingen Catharine
Published: September 2012

The Internet, Web 2.0 and Social Networking technologies are enabling citizens to actively participate in ‘citizen science’ projects by contributing data to scientific programmes via the Web. However, the limited training, knowledge and expertise of contributors can lead to poor quality, misleading or even malicious data being submitted. Subsequently, the scientific community often perceive citizen science data as not worthy of being used in serious scientific research—which in turn, leads to poor retention rates for volunteers. In this paper, we describe a technological framework that combines data quality improvements and trust metrics to enhance the reliability of citizen science data. We describe how online social trust models can provide a simple and effective mechanism for measuring the trustworthiness of community‐generated data. We also describe filtering services that remove unreliable or untrusted data and enable scientists to confidently reuse citizen science data. The resulting software services are evaluated in the context of the CoralWatch project—a citizen science project that uses volunteers to collect comprehensive data on coral reef health. Copyright © 2012 John Wiley & Sons, Ltd.
How Sustainability Leaders Communicate Corporate Activities of Sustainable Development
Authors: Guziana Bozena , Dobers Peter
Published: September 2012

In the corporate quest for sustainable development, production‐ and product‐related environmental impacts of a company can form a basis for defining the corporate environmental profile, as well as for defining environmental leaders. Awareness of the production‐ and product‐related dimensions of the environmental profile varied among companies. This paper studied descriptions and reporting of environmental issues among 19 companies ranked as Global Supersector Leaders in 2009/2010 by the Dow Jones Sustainability Index (DJSI). The results show that all of these companies are aware of production‐ and product‐related environmental aspects. There are also examples, both as headings on websites and as sections in sustainability reports, where companies structure their environmental initiatives separately with respect to production (or their own operations) and the product. The paper ends with a proposed model of corporate environmental profile. Copyright © 2012 John Wiley & Sons, Ltd and ERP Environment.