bluuebunny/crossref_metadata_2025 huggingface dataset:
Design, synthesis, molecular docking, and molecular dynamic studies of novel quinazoline derivatives as phosphodiesterase 7 inhibitors
Authors: El-Malah Afaf A. , Gineinah Magdy M. , Khayat Maan T. , Aljahdali Anfal S. , Safar Marwa M. , Almazmumi Hadeel A. , Khinkar Roaa M.
Published: April 2024

Introduction: Phosphodiesterase 7 (PDE7) is a high-affinity cyclic AMP (cAMP)-specific PDE that is expressed in immune and proinflammatory cells. In this work, we explore the possibility that selective small molecule inhibitors of this enzyme family could provide a novel approach to alleviate the inflammation that is associated with many inflammatory diseases.

Methods: A series of novel substituted 4-hydrazinoquinazoline derivatives and fused triazoloquinazolines were designed, synthesized, and evaluated in vitro for their PDE7A inhibition activities, in comparison with Theophylline, a non-selective PDE inhibitor, and BRL50481, a selective PDE7A inhibitor. This series of novel quinazoline derivatives were synthesized via multi-step reactions. The reaction sequence began with selective monohydrazinolysis of compounds 2a,b to give 3a,b. Schiff bases 4a-h were synthesized by the reaction of the quinazolylhydrazines 3a,b with various substituted aromatic aldehydes. The reaction of 4a-h with bromine in acetic acid, in turn, gave fused triazoloquinazolines 5a-h. These compounds were characterized by satisfied spectrum analyses mainly including 1HNMR, 13CNMR, and MS together with elemental analyses.

Results and discussion: The results of in vitro PDE7A inhibition activity clearly indicated that compounds 4b, 4g, 5c, and 5f exhibited good potency. Molecular docking and molecular dynamic simulation studies further supported our findings and provided the basis of interaction in terms of conventional hydrogen bonds and π-π stacking patterns. The present results lay the groundwork for developing lead compounds with improved phosphodiesterase seven inhibitory activities.
Unveiling acquired resistance to anti-EGFR therapies in colorectal cancer: a long and winding road
Authors: Ríos-Hoyo Alejandro , Monzonís Xavier , Vidal Joana , Linares Jenniffer , Montagut Clara
Published: April 2024

Emergence of acquired resistance limits the efficacy of the anti-EGFR therapies cetuximab and panitumumab in metastatic colorectal cancer. In the last decade, preclinical and clinical cohort studies have uncovered genomic alterations that confer a selective advantage to tumor cells under EGFR blockade, mainly downstream re-activation of RAS-MEK signaling and mutations in the extracellular domain of EGFR (EGFR-ECD). Liquid biopsies (genotyping of ctDNA) have been established as an excellent tool to easily monitor the dynamics of genomic alterations resistance in the blood of patients and to select patients for rechallenge with anti-EGFR therapies. Accordingly, several clinical trials have shown clinical benefit of rechallenge with anti-EGFR therapy in genomically-selected patients using ctDNA. However, alternative mechanisms underpinning resistance beyond genomics -mainly related to the tumor microenvironment-have been unveiled, specifically relevant in patients receiving chemotherapy-based multi-drug treatment in first line. This review explores the complexity of the multifaceted mechanisms that mediate secondary resistance to anti-EGFR therapies and potential therapeutic strategies to circumvent acquired resistance.
LogMS: a multi-stage log anomaly detection method based on multi-source information fusion and probability label estimation
Authors: Yu Zhongjiang , Yang Shaoping , Li Zhongtai , Li Ligang , Luo Hui , Yang Fan
Published: April 2024

Introduction: Log anomaly detection is essential for monitoring and maintaining the normal operation of systems. With the rapid development and maturation of deep learning technologies, deep learning-based log anomaly detection has become a prominent research area. However, existing methods primarily concentrate on directly detecting log data in a single stage using specific anomaly information, such as log sequential information or log semantic information. This leads to a limited understanding of log data, resulting in low detection accuracy and poor model robustness.

Methods: To tackle this challenge, we propose LogMS, a multi-stage log anomaly detection method based on multi-source information fusion and probability label estimation. Before anomaly detection, the logs undergo parsing and vectorization to capture semantic information. Subsequently, we propose a multi-source information fusion-based long short-term memory (MSIF-LSTM) network for the initial stage of anomaly log detection. By fusing semantic information, sequential information, and quantitative information, MSIF-LSTM enhances the anomaly detection capability. Furthermore, we introduce a probability label estimation-based gate recurrent unit (PLE-GRU) network, which leverages easily obtainable normal log labels to construct pseudo-labeled data and train a GRU for further detection. PLE-GRU enhances the detection capability from the perspective of label information. To ensure the overall efficiency of the LogMS, the second-stage will only be activated when anomalies are not detected in the first stage.

Results and Discussion: Experimental results demonstrate that LogMS outperforms baseline models across various log anomaly detection datasets, exhibiting superior performance in robustness testing.
The dynamic nature of parenting practices: a qualitative enquiry of parenting adolescents during COVID-19
Authors: Babu Nandita , Fatima Mehreen , Arora Manushi
Published: April 2024

Introduction

Parenting practices are known to be dynamic, evolving in response to various factors such as societal changes, cultural norms, and individual circumstances. Understanding the dynamic nature of parenting is essential for comprehending its influence on children’s development. This study aimed to explore the adaptive nature of parenting practices amidst the backdrop of the COVID-19 pandemic, a global event that provided a unique context for examining these dynamics.

Methods

In-depth semi-structured qualitative interviews were conducted with six heterogeneous couples who were parenting at least one adolescent during the pandemic. Attride-Sterling’s thematic network analysis was employed to analyze the interview data.

Results

Five global themes emerged from the data, namely, change in parenting style due to stressors, paternal versus maternal style of parenting, intergenerational transmission of parenting practices, child-centric parenting practices, positive parenting practices and evolving parent–child relationship during COVID-19.

Discussion

The findings highlight the tendency of parents to adapt their parenting styles to meet the evolving needs of their children. Understanding these dynamics is crucial for supporting families during times of crisis. Future research should explore the long-term effects of these changes and effective strategies for promoting positive parent-child relationships.
“Like another human being in the room”: a community case study of smart speakers to reduce loneliness in the oldest-old
Authors: Astell Arlene , Clayton David
Published: April 2024

This community case study examined the potential benefits of smart speakers to tackle loneliness in the oldest old adults living in supported accommodation. The program was established as a collaboration between the supported accommodation provider and a technology company to explore the feasibility of smart speakers to alleviate resident loneliness. Loneliness in later life often accompanies a shrinking social circle, loss of a spouse or increased disability. People aged 85 years of age and over are increasingly likely to experience these life events, leading to an increased risk of social isolation and loneliness. Five older people, mean age 90 years of age, who resided in supported accommodation, were given a smart speaker for 8 weeks to examine their experience with the voice assistant. The experiences of the five older adults are explored as case studies, with each person interviewed both before and after receiving the smart speaker. All five valued their smart speaker, recognised its potential for tackling loneliness, and wanted to keep it. The three most lonely individuals reported that their smart speaker made them feel less lonely and isolated through two mechanisms: (i) creating a presence and (ii) having some control over their situation. Although only a small study, these experiences suggest providing smart speakers for lonely and isolated oldest-old people, could be one way to help combat loneliness in community settings.
The effect of student-perceived teacher support on math anxiety: chain mediation of teacher–student relationship and math self-efficacy
Authors: Wang Chao , Xu Qing , Fei Wei-qun
Published: April 2024

Introduction

This study investigates the mechanisms linking students’ perceived teacher support with math anxiety, focusing on the mediating roles of the teacher–student relationship and mathematics self-efficacy.

Methods

The research was conducted with 401 fifth-grade students in China, utilizing scales for Students’ Perceived Teacher Support, Teacher–Student Relationship, Math Self-Efficacy, and Math Anxiety.

Results

Findings revealed that student-perceived math teacher support, teacher–student relationship, and math self-efficacy were all significantly negatively correlated with math anxiety. It was notably found that student-perceived math teacher support influenced math anxiety through the chain mediation of teacher–student relationship and math self-efficacy. Additionally, the effect of students’ perceived emotional support from math teachers on math anxiety, mediated by teacher–student relationship intimacy, was significant only among male students.

Discussion

These results underscore the importance of fostering positive teacher–student interactions and enhancing self-efficacy to reduce math anxiety among primary school students. The gender-specific findings regarding emotional support and relationship intimacy highlight the need for tailored strategies in addressing math anxiety.
Age-related trajectories of the development of social cognition
Authors: Yan Zhi-Xiong , He Zhe , Jiang Ling-Hui , Zou Xia
Published: April 2024

Age-related trajectories of intrinsic functional connectivity (iFC), which represent the interconnections between discrete regions of the human brain, for processes related to social cognition (SC) provide evidence for social development through neural imaging and can guide clinical interventions when such development is atypical. However, due to the lack of studies investigating brain development over a wide range of ages, the neural mechanisms of SC remain poorly understood, although considerable behavior-related evidence is available. The present study mapped vortex-wise iFC features between SC networks and the entire cerebral cortex by using common functional networks, creating the corresponding age-related trajectories. Three networks [moral cognition, theory of mind (ToM), and empathy] were selected as representative SC networks. The Enhanced Nathan Kline Institute-Rockland Sample (NKI-RS, N = 316, ages 8–83 years old) was employed delineate iFC characteristics and construct trajectories. The results showed that the SC networks display unique and overlapping iFC profiles. The iFC of the empathy network, an age-sensitive network, with dorsal attention network was found to exhibit a linear increasing pattern, that of the ventral attention network was observed to exhibit a linear decreasing pattern, and that of the somatomotor and dorsal attention networks was noted to exhibit a quadric-concave iFC pattern. Additionally, a sex-specific effect was observed for the empathy network as it exhibits linear and quadric sex-based differences in iFC with the frontoparietal and vision networks, respectively. The iFC of the ToM network with the ventral attention network exhibits a pronounced quadric-convex (inverted U-shape) trajectory. No linear or quadratic trajectories were noted in the iFC of the moral cognition network. These findings indicate that SC networks exhibit iFC with both low-level (somatomotor, vision) and high-level (attention and control) networks along specific developmental trajectories. The age-related trajectories determined in this study advance our understanding of the neural mechanisms of SC, providing valuable references for identification and intervention in cases of development of atypical SC.
Development and validation of the core life activities scale
Authors: Cho Surin , Park Kiho , Jung Dawoon , Son Gaeun , Cho Eunsil , Choi Kee-Hong
Published: April 2024

Life activities profoundly influence well-being, mental health, and quality of life. The COVID-19 pandemic has heightened the importance of monitoring these activities for psychological and emotional health. However, existing measurement tools are limited, particularly for assessing psychological health. To address this gap, we developed and validated the Core Life Activities (CORE) scale, comprising five key factors (sleep, exercise, learning, diet, and social relationships) identified in neuroscience, cognitive psychology, and gerontology. In Study 1 (n = 1,137), exploratory and confirmatory factor analyses supported a single-factor structure with good model fit (χ2 = 6.377, df = 3, TLI = 0.992, CFI = 0.998, RMSEA = 0.031), demonstrating robust internal consistency (Cronbach’s alpha = 0.776) and test–retest reliability (intraclass correlation coefficient = 0.522, p < 0.001). The CORE exhibited significant convergent validity with mental health screening tools for depressive and anxiety disorders and suicidality. Study 2 (n = 684) confirmed a significant correlation between CORE and the World Health Organisation Quality of Life Brief Version, complementing the convergent validity found in Study 1. In addition, discriminant validity was confirmed by a non-significant correlation with the COVID-19 Preventive Behavior Scale. The findings establish the CORE as a reliable and valid tool, offering a simple yet comprehensive measure for assessing core life activities with potential applications in diverse environments.
Unraveling the core symptoms of mental health in senior grade three students- a network analysis
Authors: Fang Guoxiang , Wang Ying , Yuan Huiling , Yan Ne , Zhi Shaomin
Published: April 2024

Background

Adolescence is not only an important transitional period of many developmental challenges, but also a high risk period for mental health problems. Psychotherapy is recommended for mental health problems in adolescents, but its effectiveness is not always satisfactory. One possible contributing factor may be the lack of clarity surrounding core symptoms.

Methods

In this study, we investigated the mental health status of senior grade three students, a group of adolescents facing college entrance exams, by the Middle School Student Mental Health Test (MHT) and analyzed the core symptoms by network analysis. This study was conducted through an online survey platform (www.xiaodongai.com) from 15 February 2023 to 28 March 2024. The subjects scanned a QR code with their mobile phone to receive the questionnaire.

Results

The mean age of these 625 students were 18.11 ± 2.90 years. There are 238 male participants and 387 female participants. 107 individuals scored above 56 (107/461, 23.2%), with individual scale scores over 8 up to over 60% of participating students. Notably, the top three prominent symptoms were “academic anxiety”, “allergic tendency” and “somatic symptoms”. However, upon conducting network analysis, it became evident that three strongest edges in this network were “somatic symptoms” and “impulsive tendency”, “academic anxiety” and “social anxiety” as well as “social anxiety” and “Loneliness tendency”. “somatic symptoms”, “social anxiety” and “self-blame tendency” exerted the highest expected influence. This suggests that, statistically speaking, these three symptoms exhibited the strongest interconnections within the network.

Limitation

Cross-sectional analysis; Bias in self-reported variables.

Conclusion

These findings can deepen the knowledge of mental health among senior grade three students and provide some implications (i.e., targeting symptoms having highest expected influence) for clinical prevention and intervention to address the mental health needs of this particular group.
Electroacupuncture stimulation modulates functional brain connectivity in the treatment of pediatric cerebral palsy: a case report
Authors: Sun Zongbo , Li Chenglin , Sun Laixin , Yang Wenwen , Qu Xueli , Li Yuanyuan , Duan Xiao , Guo Fengyu , Sun Xuejing , Yang Mingzhu , Qi Tong , Zhu Longyun , Wang Shuai , Xia Yu , Du Yanan , Luo Shuhui , Li Lingling , Gu Yu , Wang Yaya , Yang Li
Published: April 2024

Background

Pediatric cerebral palsy (CP) is a non-progressive brain injury syndrome characterized by central motor dysfunction and insufficient brain coordination ability. The etiology of CP is complex and often accompanied by diverse complications such as intellectual disability and language disorders, making clinical treatment difficult. Despite the availability of pharmacological interventions, rehabilitation programs, and spasticity relief surgery as treatment options for CP, their effectiveness is still constrained. Electroacupuncture (EA) stimulation has demonstrated great improvements in motor function, but its comprehensive, objective therapeutic effects on pediatric CP remain to be clarified.

Methods

We present a case of a 5-year-old Chinese female child who was diagnosed with CP at the age of 4. The patient exhibited severe impairments in motor, language, social, and cognitive functions. We performed a 3-month period of EA rehabilitation, obtaining resting state functional magnetic resonance imaging (rs-fMRI) of the patient at 0 month, 3 months and 5 months since treatment started, then characterized brain functional connectivity patterns in each phase for comparison.

Results

After a 12-month follow-up, notable advancements were observed in the patient’s language and social symptoms. Changes of functional connectivity patterns confirmed this therapeutic effect and showed specific benefits for different recovery phase: starting from language functions then modulating social participation and other developmental behaviors.

Conclusion

This is a pioneering report demonstrating the longitudinal effect of EA stimulation on functional brain connectivity in CP patients, suggesting EA an effective intervention for developmental disabilities (especially language and social dysfunctions) associated with pediatric CP.
How internet healthcare information overflow affects farmers’ healthcare consumption: insights from China
Authors: Ming Yu , Xia Chen
Published: April 2024

Introduction

In the context of the deep coupling and synergistic development of digital villages and healthy villages, the development of China’s rural society harbors a huge potential for medical and healthcare consumption.

Methods

On the basis of theoretical research, a framework was constructed to analyze the influence mechanism of farmers’ medical and healthcare consumption in the context of Internet medical information overflow, and empirically examines the research and analysis framework by using the 2020 China Household Tracking Survey data with the OLS model, mediation effect model, and instrumental variable method.

Results

It is found that Internet medical information spillover has a “crowding-in effect” on farmers’ healthcare consumption; Medical attendance behavior, economic capital utilize the intermediary effect between Internet medical information spillover and farmers’ healthcare consumption. And there is age group heterogeneity in the effect of Internet medical information spillover on farmers’ healthcare consumption, The ability of rural middle-aged and old-aged groups to recognize new things such as Internet medical information needs to be improved, so the overflow of Internet medical information will induce rural middle-aged and old-aged groups to generate a certain amount of medical and health care consumption. However, the impact on healthcare consumption is not sensitive to the youth cohort group.

Discussion

The sinking of Internet medical resources should be accelerated in the future to promote the high-quality development of rural medical and health services, at the same time the “Internet + healthcare services” should be optimized to promote scientific and rational stratification of farmers’ access to healthcare, and economic capital for farmers’ access to health care should be improved in order to alleviate the burden of health care, etc.
Value contribution of blood-based neurofilament light chain as a biomarker in multiple sclerosis using multi-criteria decision analysis
Authors: Monreal Enric , Ruiz Pilar Díaz , San Román Isabel López , Rodríguez-Antigüedad Alfredo , Moya-Molina Miguel Ángel , Álvarez Ana , García-Arcelay Elena , Maurino Jorge , Shepherd John , Cabrera Álvaro Pérez , Villar Luisa María
Published: April 2024

Introduction

Multiple sclerosis (MS) is a chronic autoimmune demyelinating disease that represents a leading cause of non-traumatic disability among young and middle-aged adults. MS is characterized by neurodegeneration caused by axonal injury. Current clinical and radiological markers often lack the sensitivity and specificity required to detect inflammatory activity and neurodegeneration, highlighting the need for better approaches. After neuronal injury, neurofilament light chains (NfL) are released into the cerebrospinal fluid, and eventually into blood. Thus, blood-based NfL could be used as a potential biomarker for inflammatory activity, neurodegeneration, and treatment response in MS. The objective of this study was to determine the value contribution of blood-based NfL as a biomarker in MS in Spain using the Multi-Criteria Decision Analysis (MCDA) methodology.

Materials and methods

A literature review was performed, and the results were synthesized in the evidence matrix following the criteria included in the MCDA framework. The study was conducted by a multidisciplinary group of six experts. Participants were trained in MCDA and scored the evidence matrix. Results were analyzed and discussed in a group meeting through reflective MCDA discussion methodology.

Results

MS was considered a severe condition as it is associated with significant disability. There are unmet needs in MS as a disease, but also in terms of biomarkers since no blood biomarker is available in clinical practice to determine disease activity, prognostic assessment, and response to treatment. The results of the present study suggest that quantification of blood-based NfL may represent a safe option to determine inflammation, neurodegeneration, and response to treatments in clinical practice, as well as to complement data to improve the sensitivity of the diagnosis. Participants considered that blood-based NfL could result in a lower use of expensive tests such as magnetic resonance imaging scans and could provide cost-savings by avoiding ineffective treatments. Lower indirect costs could also be expected due to a lower impact of disability consequences. Overall, blood-based NfL measurement is supported by high-quality evidence.

Conclusion

Based on MCDA methodology and the experience of a multidisciplinary group of six stakeholders, blood-based NfL measurement might represent a high-value-option for the management of MS in Spain.
Suggesting global insights to local challenges: expanding financing of rehabilitation services in low and middle-income countries
Authors: Bachani Abdulgafoor M. , Bentley Jacob A. , Kautsar Hunied , Neill Rachel , Trujillo Antonio J.
Published: April 2024

Purpose

Following the rapid transition to non-communicable diseases, increases in injury, and subsequent disability, the world—especially low and middle-income countries (LMICs)—remains ill-equipped for increased demand for rehabilitative services and assistive technology. This scoping review explores rehabilitation financing models used throughout the world and identifies “state of the art” rehabilitation financing strategies to identify opportunities and challenges to expand financing of rehabilitation.

Material and methods

We searched peer-reviewed and grey literature for articles containing information on rehabilitation financing in both LMICs and high-income countries.

Results

Forty-two articles were included, highlighting various rehabilitation financing mechanism which involves user fees and other innovative payment as bundled or pooled schemes. Few studies explore policy options to increase investment in the supply of services.

Conclusion

this paper highlights opportunities to expand rehabilitation services, namely through promotion of private investment, improvement in provider reimbursement mechanism as well as expanding educational grants to bolster labor supply incentive, and the investment in public and private insurance schemes. Mechanisms of reimbursement are frequently based on global budget and salary which are helpful to control cost escalation but represent important barriers to expand supply and quality of services.
Utilization of the Integrated Management of Newborn and Childhood Illness (IMNCI) protocol and associated factors among health care workers in health centers of South Gondar Zone, Northwest Ethiopia: an institution-based mixed study
Authors: Belete Abraham Addis , Agumas Yeshambel , Tsehay Asmamaw Ketemaw , Ayele Habtamu Molla
Published: April 2024

Introduction

Globally, 11 million children have died before reaching their fifth birthday. The introduction of the Integrated Management of Newborn and Childhood Illness (IMNCI) protocol reduces the morbidity and mortality rates among children under the age of 5. However, the share of neonatal mortality is increasing. As a result, the United Nations has established sustainable development goals to reduce national neonatal death rates through the utilization of the Integrated Management of Newborn and Childhood Illness protocol as the main tool for 12 per 1,000 live births by 2030. However, the death rate from preventable causes has increased owing to the low utilization of the protocol.

Objective

The objective of this research is to assess the utilization of the IMNCI protocol and associated factors among healthcare workers (HCW) in health centers at the South Gondar Zone, Northwest Ethiopia, in 2022.

Methods

The institution-based mixed study design was conducted from November to December 2022 at the South Gondar Zone, Amhara. A total of 422 HCW were selected using a computer-generated random-number generator. Data were cleaned and entered into EpiData 3.1 software and analyzed using SPSS version 25.0. Binary logistic regression was used to identify candidates for multivariable logistic analysis with p-value < 0.2, and for multivariable analysis, p-value < 0.05, with a 95% confidence interval, was considered significant. Thematic analysis was used for the qualitative data.

Results

In total, 417 respondents were included in the final analysis. The overall response rate was 98.8%, and the mean age was 30.01 years. The results showed that the proportion of IMNCI utilization was 63.1%. The odds of the utilization of IMNCI protocol among HCW who took training were 3.13 times higher than those among HCW who did not take training [adjusted odds ratio (AOR) = 3.13, 95% CI: 1.594, 6.147]. The lack of drugs reduces the utilization of the IMNCI protocol by 75.7% compared with the use of drugs (AOR = 0.243, CI: 95%:0.128, 0.464). HCW who always referred to the chart booklet during case management were 3.34 times more likely to utilize the IMNCI protocol (AOR = 3.34, 95% CI: 1.99, 5.60) compared with those who did not refer to the chart booklet.

Conclusions and recommendations

The utilization of the IMNCI protocol was low. A shortage of medical consumables and equipment attitude and training were identified as factors that affected the utilization of the protocol. Therefore, the availability of necessary logistics and training for employees with regular supportive supervision and monitoring should be conducted with the integration of sectors at the district and zone levels.
The Maternal and Infant Environmental Health Riskscape study of perinatal disparities in greater Houston: rationale, study design and participant profiles
Authors: Symanski Elaine , Whitworth Kristina W. , Mendez-Figueroa Hector , Aagaard Kjersti M. , Moussa Iman , Alvarez Juan , Chardon Fabian Adrien , Kannan Kurunthachalam , Walker Cheryl L. , Coarfa Cristian , Suter Melissa A. , Salihu Hamisu M.
Published: April 2024

Introduction

The Maternal and Infant Environmental Health Riskscape (MIEHR) Center was established to address the interplay among chemical and non-chemical stressors in the biological, physical, social, and built environments that disproportionately impact perinatal health among Black pregnant people in a large and diverse urban area with documented disparities in the U.S.

Methods

The MIEHR cohort is recruiting non-Hispanic Black and non-Hispanic white pregnant people who deliver their infants at major obstetric hospitals in Houston, Texas. At enrollment, all participants are asked to provide urine samples for chemical [metals, cotinine, and polycyclic aromatic hydrocarbons (PAHs)] analyses and blood samples. A subset of the cohort is asked to provide oral and vaginal swabs, and fecal samples. Questionnaire and electronic health record data gather information about residential address history during pregnancy, pregnancy history and prenatal care, sociodemographic and lifestyle factors, experiences of discrimination and stress, and sources of social support. Using information on where a participant lived during their pregnancy, features of their neighborhood environment are characterized. We provide summaries of key individual- and neighborhood-level features of the entire cohort, as well as for Black and white participants separately.

Results

Between April 2021 and February 2023, 1,244 pregnant people were recruited. Nearly all participants provided urine samples and slightly less than half provided blood samples. PAH exposure patterns as assessed on 47% of participants thus far showed varying levels depending on metabolite as compared to previous studies. Additionally, analyses suggest differences between Black and white pregnant people in experiences of discrimination, stress, and levels of social support, as well as in neighborhood characteristics.

Discussion

Our findings to date highlight racial differences in experiences of discrimination, stress, and levels of support, as well as neighborhood characteristics. Recruitment of the cohort is ongoing and additional neighborhood metrics are being constructed. Biospecimens will be analyzed for metals and PAH metabolites (urine samples), miRNAs (plasma samples) and the microbiome (oral swabs). Once enrollment ends, formal assessments are planned to elucidate individual- and neighborhood-level features in the environmental riskscape that contribute to Black-White disparities in perinatal health.
Precise micromotion compensation of a tilted ion chain
Authors: Hogle Craig W. , Burch Ashlyn D. , Sterk Jonathan D. , Chow Matthew N. H. , Ivory Megan , Lobser Daniel S. , Maunz Peter , Van Der Wall Jay , Yale Christopher G. , Clark Susan M. , Stick Daniel , Revelle Melissa C.
Published: April 2024

Excess micromotion can be a substantial source of errors in trapped-ion based quantum processors and clocks due to the sensitivity of the internal states of the ion to external fields and motion. This problem can be fixed by compensating background electric fields in order to position ions at the RF node and minimize their driven micromotion. Here we describe techniques for compensating ion chains in scalable surface ion traps. These traps are capable of cancelling stray electric fields with fine spatial resolution in order to compensate multiple closely spaced ions due to their large number of relatively small control electrodes. We demonstrate a technique that compensates an ion chain to better than 5 V/m and within 0.1 degrees of chain rotation.
Strategic mapping of onion supply chains: a comprehensive analysis of production and post-harvest processes in Northwest Ethiopia
Authors: Yeshiwas Yebirzaf , Alemayehu Melkamu , Adgo Enyew
Published: April 2024

Introduction

Onion is a significant vegetable crop in Ethiopia, serving as a source of income for smallholder farmers. However, various challenges in the production and post-harvest handling processes impede a consistent supply and marketing of the crop. This study focused on a comprehensive analysis of the onion supply chain, ranging from production to post-harvest handling, to address the existing production and marketing processes. The research initiative was undertaken to map the onion supply chain from farmers to consumers, intending to establish an improved marketing system in northwest Ethiopia.

Methods

The study area covered three onion-producing districts of the Amhara Region. Data collection involved interviews, observations, and market assessments using a structured questionnaire. Sampling followed a multistage technique. The analysis included descriptive statistics and food system analysis to map the supply chain and estimate marketing margins.

Results and Discussion

Post-harvest loss in onion production presents a major obstacle in the farming sector, impacting its growth. The study identified six alternative channels for onion marketing where different actors are involved throughout the supply chain. Key stakeholders include farmers, local collectors, brokers, transporters, wholesalers, retailers, and consumers. Packaging and sorting activities are implemented at different supply chain stages to minimize post-harvest losses. Farm-level activities, including curing, sorting, grading, and ventilating, are crucial for reducing losses. The perishable nature of onion bulbs and the existing production and handling challenges exacerbate post-harvest losses. Efforts to address this challenge demand a comprehensive approach, integrating interventions across the value chain, from improved cultivars and storage infrastructure to enhanced market access strategies. Hence, stakeholders and governmental organizations are urged to promote onion value-addition technologies, including the establishment of processing industries. Such endeavors promote collaborative efforts across the onion supply chain, ensuring sustainable benefits for producers and traders.
Radiographic and clinical outcomes of robot-assisted pedicle screw instrumentation for adolescent idiopathic scoliosis
Authors: Chen Yuan-Shao , Lin Yu-Hsien , Wu Yun-Che , Shih Cheng-Min , Chen Kun-Huei , Lee Cheng-Hung , Lu Wen-Hsien , Pan Chien-Chou
Published: April 2024

Introduction

Pedicle screw instrumentation (PSI) serves as the widely accepted surgical treatment for adolescent idiopathic scoliosis (AIS). The accuracy of screw positioning has remarkably improved with robotic assistance. Nonetheless, its impact on radiographic and clinical outcomes remains unexplored. This study aimed to investigate the radiographic and clinical outcomes of robot-assisted PSI vs. conventional freehand method in AIS patients.

Methods

Data of AIS patients who underwent PSI with all pedicle screws between April 2013 and March 2022 were included and retrospectively analyzed; those with hybrid implants were excluded. Recruited individuals were divided into the Robot-assisted or Freehand group according to the technique used. Radiographic parameters and clinical outcome measures were documented.

Results

In total, 50 patients (19, Freehand group; 31, Robot-assisted group) were eligible, with an average age and follow-up period of 17.6 years and 60.2 months, respectively, and female predominance (40/50, 80.0%). The correction rates of Cobb's angles for both groups were significant postoperatively. Compared to freehand, the robot-assisted technique achieved a significantly reduced breech rate and provided better trunk shift and radiographic shoulder height correction with preserved lumbar lordosis, resulting in significantly improved visual analog scale scores for back pain from the third postoperative month.

Conclusion

Overall, robot-assisted PSI provides satisfactory radiographic and clinical outcomes in AIS patients.
Transumbilical laparoscopy for pneumoperitoneum establishment: a comprehensive multicentre evaluation affirming safety, feasibility, and a range of clinical benefits
Authors: Rizzuto Antonia , Bozzarello Cristina , Andreuccetti Jacopo , Amaddeo Angela , Iannello Antonio Maria , Sagnelli Carlo , Cirocchi Roberto , Cuccurullo Diego , Pignata Giusto , Corcione Francesco
Published: April 2024

Introduction

Transumbilical laparoscopy (TUL) has emerged as a promising technique for establishing pneumoperitoneum in laparoscopic cholecystectomy, offering potential safety, feasibility, and clinical benefits. This retrospective multicentre study aims to evaluate the efficacy and outcomes of TUL in the management of gallbladder diseases.

Methods

A retrospective analysis was conducted on a cohort of 2,543 patients who underwent TUL between 2011 and 2021 across various medical institutions in Italy. Data collection included demographic, clinical, intraoperative, and postoperative parameters. Standardized protocols were followed for preoperative and postoperative management. The TUL technique involved precise anatomical incision and trocar placement.

Results

The study demonstrated favorable outcomes associated with TUL, including a low conversion rate to open surgery (0.55%), minimal intraoperative complications (0.16%), and short hospital stays (average 2.4 days). The incidence of incisional hernias was notably low (0.4%). Comparison with existing literature revealed consistent findings and provided unique insights into the advantages of TUL.

Discussion

Despite limitations, such as the absence of a control group and the retrospective nature of the study, the findings contribute valuable insights to the literature. They inform surgical decision-making and advance patient care in laparoscopic cholecystectomy for gallbladder diseases.

Conclusion

Transumbilical laparoscopy shows promise as a safe and feasible technique for establishing pneumoperitoneum in laparoscopic cholecystectomy. The study's findings support its clinical benefits, including low conversion rates, minimal complications, and short hospital stays. Further research, including prospective studies with control groups, is warranted to validate these results and optimize patient outcomes.
Impact of Asian and Black Donor and Recipient Ethnicity on the Outcomes After Deceased Donor Kidney Transplantation in the United Kingdom
Authors: Hakeem Abdul Rahman , Asthana Sonal , Johnson Rachel , Brown Chloe , Ahmad Niaz
Published: April 2024

Patients of Asian and black ethnicity face disadvantage on the renal transplant waiting list in the UK, because of lack of human leucocyte antigen and blood group matched donors from an overwhelmingly white deceased donor pool. This study evaluates outcomes of renal allografts from Asian and black donors. The UK Transplant Registry was analysed for adult deceased donor kidney only transplants performed between 2001 and 2015. Asian and black ethnicity patients constituted 12.4% and 6.7% of all deceased donor recipients but only 1.6% and 1.2% of all deceased donors, respectively. Unadjusted survival analysis demonstrated significantly inferior long-term allograft outcomes associated with Asian and black donors, compared to white donors. On Cox-regression analysis, Asian donor and black recipient ethnicities were associated with poorer outcomes than white counterparts, and on ethnicity matching, compared with the white donor–white recipient baseline group and adjusting for other donor and recipient factors, 5-year graft outcomes were significantly poorer for black donor-black recipient, Asian donor-white recipient, and white donor-black recipient combinations in decreasing order of worse unadjusted 5-year graft survival. Increased deceased donation among ethnic minorities could benefit the recipient pool by increasing available organs. However, it may require a refined approach to enhance outcomes.
Analysis and Design of Bat-Like Flapping-Wing Aircraft
Authors: Wang Fan , Pei Xinbiao , Wu Guangxin , Bai Yue
Published: April 2024

As the only flying mammal in nature, bats have superb flight skills and aerodynamic characteristics that have been the subject of research by scholars from all over the world. In recent years, the research on bionic flapping-wing aircraft has made good progress. However, such research mostly uses birds or insects as the research objects, and there are few studies on bat-imitating flapping-wing aircraft. This paper combines the characteristics of bats’ flexible wings to model and analyze the aerodynamic theory and parameters of the flexible wings of bat-like flapping aircraft. The longitudinal dynamic and kinematic model design of bat-like flapping aircraft is based on the pitch angle of LQR. In terms of height control, the controller uses energy control methods to complete the closed-loop longitudinal channel control of the bat-like flapping aircraft. Finally, this study performed the simulation and flight experimentation of the designed bat-like flapping aircraft, demonstrating the correctness of this system.
Study of Fatigue Performance of Ultra-Short Stud Connectors in Ultra-High Performance Concrete
Authors: An Ran , Wang You-Zhi , Zhuang Mei-Ling , Yang Zhen , Tian Chang-Jin , Qiu Kai , Cheng Meng-Ying , Lv Zhao-Yuan
Published: April 2024

Steel–UHPC composite bridge decking made of ultra-high performance concrete (UHPC) has been progressively employed to reinforce historic steel bridges. The coordinated force and deformation between the steel deck and UHPC are therefore greatly influenced by the shear stud connectors at the shear interface. Four fatigue push-out specimens of ultra-short studs with an aspect ratio of 1.84 in UHPC were examined to investigate the fatigue properties of ultra-short studs with an aspect ratio below 2.0 utilized in UHPC reinforcing aged steel bridges. The test results indicated that three failure modes—fracture surface at stud shank, fracture surface at steel flange, and fracture surface at stud cap—were noted for ultra-short studs in UHPC under various load ranges. The fatigue life decreased from 1287.3 × 104 to 24.4 × 104 as the shear stress range of the stud increased from 88.2 MPa to 158.8 MPa. The UHPC can ensure that the failure mode of the specimens was stud shank failure. Based on the test and literature results, a fatigue strength design S–N curve for short studs in UHPC was proposed, and calculation models for stiffness degradation and plastic slip accumulation of short studs in UHPC were established. The employment of ultra-short studs in the field of UHPC reinforcing aging steel bridges can be supported by the research findings.
Breast Cancer Polygenic Risk Score Validation and Effects of Variable Imputation
Authors: Beck Jeffrey J. , Slunecka John L. , Johnson Brandon N. , Van Asselt Austin J. , Finnicum Casey T. , Ageton Cheryl , Krie Amy , Nickles Heidi , Cowan Kenneth , Maxwell Jessica , Boomsma Dorret I. , de Geus Eco , Ehli Erik A. , Hottenga Jouke-Jan
Published: April 2024

Breast cancer (BC) is a complex disease affecting one in eight women in the USA. Advances in population genomics have led to the development of polygenic risk scores (PRSs) with the potential to augment current risk models, but replication is often limited. We evaluated 2 robust PRSs with 313 and 3820 SNPs and the effects of multiple genotype imputation replications in BC cases and control populations. Biological samples from BC cases and cancer-free controls were drawn from three European ancestry cohorts. Genotyping on the Illumina Global Screening Array was followed by stringent quality control measures and 20 genotype imputation replications. A total of 468 unrelated cases and 4337 controls were scored, revealing significant differences in mean PRS percentiles between cases and controls (p < 0.001) for both SNP sets (313-SNP PRS: 52.81 and 48.07; 3820-SNP PRS: 55.45 and 49.81), with receiver operating characteristic curve analysis showing area under the curve values of 0.596 and 0.603 for the 313-SNP and 3820-SNP PRS, respectively. PRS fluctuations (from ~2–3% up to 9%) emerged across imputation iterations. Our study robustly reaffirms the predictive capacity of PRSs for BC by replicating their performance in an independent BC population and showcases the need to average imputed scores for reliable outcomes.
High-Grade Glioma Recurrence Is Delayed in Hispanic Patients despite Severe Social Vulnerability: A Retrospective Cohort Study
Authors: Reynolds Joshua A. , Pecorari Isabella L. , Ledet Alexander , Agarwal Vijay
Published: April 2024

High-grade gliomas (HGGs; WHO grade III or IV) are the most common and lethal brain malignancy. Patients of Hispanic ethnicity are diagnosed with HGGs earlier than non-Hispanic patients, but they exhibit improved HGG survival following diagnosis. Either environmental or biological factors could explain this survival benefit. We aimed to determine if post-diagnosis advantages would still be present in Hispanic patients with high social vulnerability, an environmental condition predisposing patients to poor oncologic outcomes. HGG outcomes were retrospectively assessed in a cohort of 22 Hispanic patients and 33 non-Hispanic patients treated for HGGs from 2015 to 2020 at a single institution that serves a highly vulnerable region. Compared to non-Hispanic patients, Hispanic patients demonstrated higher social vulnerability index scores (96.8 + 0.7 vs. 76.3 + 4.6; *** p = 0.0002) and a 14-month longer interval between diagnosis and recurrence (19.7 + 5.9 (n = 13) vs. 5.5 + 0.6 months (n = 19); ** p = 0.001). In only those patients with more aggressive IDH-1 wildtype tumors (glioblastoma), Hispanic ethnicity still related to a longer time before recurrence (15.8 + 5.9 months (n = 9); 5.5 + 0.6 months (n = 18); * p = 0.034), and in a multivariate analysis, Hispanic ethnicity predicted time-to-recurrence (* p = 0.027) independent of patient age, functional status, MGMT gene methylation, or treatments received. Therefore, environmental factors, specifically social vulnerability, did not obscure the post-diagnosis benefits associated with Hispanic ethnicity. In future experiments, basic studies should be prioritized which investigate the cellular or genetic mechanisms underlying this ethnicity effect on HGG progression in the hopes of improving care for these devastating malignancies.