bluuebunny/crossref_metadata_2025 huggingface dataset:
Hydrogen Breath Tests: Are They Really Useful in the Nutritional Management of Digestive Disease?
Authors: Usai-Satta Paolo , Oppia Francesco , Lai Mariantonia , Cabras Francesco
Published: March 2021

Background: Carbohydrate malabsorption is a frequent digestive problem associated with abdominal pain, bloating and diarrhea. Hydrogen breath testing (BT) represents the most reliable and validated diagnostic technique. The aim of this manuscript was to clarify the usefulness of BTs in the nutritional management of these disorders. Methods: A literature search for BT related to carbohydrate malabsorption was carried out using the online databases of Pubmed, Medline and Cochrane. Results: Lactose BT showed good sensitivity and optimal specificity for lactose malabsorption. However, an accurate diagnosis of lactose intolerance should require blind lactose challenge although this method is difficult to utilize in clinical practice. Regarding dose-depending fructose and sorbitol malabsorption, BTs could not add diagnostic advantage compared with a direct dietary intervention. In addition, carbohydrates are fundamental components of fermentable oligo-, di- and monosaccharides and polyols (FODMAPs). Before starting a low FODMAP diet, lactose BT should be suggested in a population with low prevalence of hypolactasia. Conclusions: BTs represent a valid and noninvasive technique in many digestive conditions. Regarding the management of carbohydrate intolerance, lactose BT can be recommended with some limitations. No sufficient evidence is available about the usefulness of BTs for other sugars in clinical practice.
Zur: Zinc-Sensing Transcriptional Regulator in a Diverse Set of Bacterial Species
Authors: Kandari Divya , Joshi Hemant , Bhatnagar Rakesh
Published: March 2021

Zinc (Zn) is the quintessential d block metal, needed for survival in all living organisms. While Zn is an essential element, its excess is deleterious, therefore, maintenance of its intracellular concentrations is needed for survival. The living organisms, during the course of evolution, developed proteins that can track the limitation or excess of necessary metal ions, thus providing survival benefits under variable environmental conditions. Zinc uptake regulator (Zur) is a regulatory transcriptional factor of the FUR superfamily of proteins, abundant among the bacterial species and known for its intracellular Zn sensing ability. In this study, we highlight the roles played by Zur in maintaining the Zn levels in various bacterial species as well as the fact that in recent years Zur has emerged not only as a Zn homeostatic regulator but also as a protein involved directly or indirectly in virulence of some pathogens. This functional aspect of Zur could be exploited in the ventures for the identification of newer antimicrobial targets. Despite extensive research on Zur, the insights into its overall regulon and its moonlighting functions in various pathogens yet remain to be explored. Here in this review, we aim to summarise the disparate functional aspects of Zur proteins present in various bacterial species.
Doxepin Exacerbates Renal Damage, Glucose Intolerance, Nonalcoholic Fatty Liver Disease, and Urinary Chromium Loss in Obese Mice
Authors: Chang Geng-Ruei , Hou Po-Hsun , Yang Wei-Cheng , Wang Chao-Min , Fan Pei-Shan , Liao Huei-Jyuan , Chen To-Pang
Published: March 2021

Doxepin is commonly prescribed for depression and anxiety treatment. Doxepin-related disruptions to metabolism and renal/hepatic adverse effects remain unclear; thus, the underlying mechanism of action warrants further research. Here, we investigated how doxepin affects lipid change, glucose homeostasis, chromium (Cr) distribution, renal impairment, liver damage, and fatty liver scores in C57BL6/J mice subjected to a high-fat diet and 5 mg/kg/day doxepin treatment for eight weeks. We noted that the treated mice had higher body, kidney, liver, retroperitoneal, and epididymal white adipose tissue weights; serum and liver triglyceride, alanine aminotransferase, aspartate aminotransferase, blood urea nitrogen, and creatinine levels; daily food efficiency; and liver lipid regulation marker expression. They also demonstrated exacerbated insulin resistance and glucose intolerance with lower Akt phosphorylation, GLUT4 expression, and renal damage as well as higher reactive oxygen species and interleukin 1 and lower catalase, superoxide dismutase, and glutathione peroxidase levels. The treated mice had a net-negative Cr balance due to increased urinary excretion, leading to Cr mobilization, delaying hyperglycemia recovery. Furthermore, they had considerably increased fatty liver scores, paralleling increases in adiponectin, FASN, PNPLA3, FABP4 mRNA, and SREBP1 mRNA levels. In conclusion, doxepin administration potentially worsens renal injury, nonalcoholic fatty liver disease, and diabetes.
Pipecolisporin, a Novel Cyclic Peptide with Antimalarial and Antitrypanosome Activities from a Wheat Endophytic Nigrospora oryzae
Authors: Fernández-Pastor Ignacio , González-Menéndez Victor , Annang Frederick , Toro Clara , Mackenzie Thomas , Bosch-Navarrete Cristina , Genilloud Olga , Reyes Fernando
Published: March 2021

A novel cyclic antimalarial and antitrypanosome hexapeptide, pipecolisporin (1), was isolated from cultures of Nigrospora oryzae CF-298113, a fungal endophyte isolated from roots of Triticum sp. collected in a traditional agricultural land of Montefrío, Granada, Spain. The structure of this compound, including its absolute configuration, was elucidated by HRMS, 1-D and 2-D NMR spectroscopy, and Marfey’s analysis. This metabolite displayed interesting activity against Plasmodium falciparum and Trypanosoma cruzi, with IC50 values in the micromolar range, and no significant cytotoxicity against the human cancer cell lines A549, A2058, MCF7, MIA PaCa-2, and HepG2.
A Comprehensive Approach to Compatibility Testing Using Chromatographic, Thermal and Spectroscopic Techniques: Evaluation of Potential for a Monolayer Fixed-Dose Combination of 6-Mercaptopurine and Folic Acid
Authors: Brusač Edvin , Jeličić Mario-Livio , Cvetnić Matija , Amidžić Klarić Daniela , Nigović Biljana , Mornar Ana
Published: March 2021

In this work, a systematical compatibility investigation of 6-mercaptopurine and folic acid, two commonly used medications in the treatment of inflammatory bowel disease, for the needs of a fixed-dose combination development strategy is shown. Various techniques and approaches, such as differential scanning calorimetry, isothermal stress testing, attenuated total reflectance–Fourier-transform infrared spectroscopy, dissolution medium stability and forced degradation studies, were used to elucidate the possible interactions from different aspects. The results predominantly point to the absence of physicochemical interactions between the examined substances in a variety of possible conditions. However, the forced degradation of the blend of substances and excipients in basic conditions showed a drastic degradation of 6-mercaptopurine, signifying that attention needs to be directed to the careful selection of the excipients for the formulation. To sum up, our findings indicate that a fixed-dose combination of 6-mercaptopurine and folic acid could be produced using one formulation blend, immensely simplifying its manufacture.
In-Vitro Application of Magnetic Hybrid Niosomes: Targeted siRNA-Delivery for Enhanced Breast Cancer Therapy
Authors: Maurer Viktor , Altin Selin , Ag Seleci Didem , Zarinwall Ajmal , Temel Bilal , Vogt Peter M. , Strauß Sarah , Stahl Frank , Scheper Thomas , Bucan Vesna , Garnweitner Georg
Published: March 2021

Even though the administration of chemotherapeutic agents such as erlotinib is clinically established for the treatment of breast cancer, its efficiency and the therapy outcome can be greatly improved using RNA interference (RNAi) mechanisms for a combinational therapy. However, the cellular uptake of bare small interfering RNA (siRNA) is insufficient and its fast degradation in the bloodstream leads to a lacking delivery and no suitable accumulation of siRNA inside the target tissues. To address these problems, non-ionic surfactant vesicles (niosomes) were used as a nanocarrier platform to encapsulate Lifeguard (LFG)-specific siRNA inside the hydrophilic core. A preceding entrapment of superparamagnetic iron-oxide nanoparticles (FexOy-NPs) inside the niosomal bilayer structure was achieved in order to enhance the cellular uptake via an external magnetic manipulation. After verifying a highly effective entrapment of the siRNA, the resulting hybrid niosomes were administered to BT-474 cells in a combinational therapy with either erlotinib or trastuzumab and monitored regarding the induced apoptosis. The obtained results demonstrated that the nanocarrier successfully caused a downregulation of the LFG gene in BT-474 cells, which led to an increased efficacy of the chemotherapeutics compared to plainly added siRNA. Especially the application of an external magnetic field enhanced the internalization of siRNA, therefore increasing the activation of apoptotic signaling pathways. Considering the improved therapy outcome as well as the high encapsulation efficiency, the formulated hybrid niosomes meet the requirements for a cost-effective commercialization and can be considered as a promising candidate for future siRNA delivery agents.
Liposomes to Augment Dialysis in Preclinical Models: A Structured Review
Authors: Hart Kevin , Harvey Martyn , Tang Mingtan , Wu Zimei , Cave Grant
Published: March 2021

In recent years, a number of groups have been investigating the use of “empty” liposomes with no drug loaded as scavengers both for exogenous intoxicants and endogenous toxic molecules. Preclinical trials have demonstrated that repurposing liposomes to sequester such compounds may prove clinically useful. The use of such “empty” liposomes in the dialysate during dialysis avoids recognition by complement surveillance, allowing high doses of liposomes to be used. The “reach” of dialysis may also be increased to molecules that are not traditionally dialysable. We aim to review the current literature in this area with the aims of increasing awareness and informing further research. A structured literature search identified thirteen papers which met the inclusion criteria. Augmenting the extraction of ammonia in hepatic failure with pH-gradient liposomes with acidic centres in peritoneal dialysis is the most studied area, with work progressing toward phase one trials. Liposomes used to augment the removal of exogenous intoxicants and protein-bound uraemic and hepatic toxins that accumulate in these organ failures and liposome-supported enzymatic dialysis have also been studied. It is conceivable that liposomes will be repurposed from the role of pharmaceutical vectors to gain further indications as clinically useful nanomedical antidotes/treatments within the next decade.
Chondrogenic Commitment of Human Bone Marrow Mesenchymal Stem Cells in a Perfused Collagen Hydrogel Functionalized with hTGF-β1-Releasing PLGA Microcarrier
Authors: Lamparelli Erwin Pavel , Lovecchio Joseph , Ciardulli Maria Camilla , Giudice Valentina , Dale Tina P. , Selleri Carmine , Forsyth Nicholas , Giordano Emanuele , Maffulli Nicola , Della Porta Giovanna
Published: March 2021

Tissue engineering strategies can be relevant for cartilage repair and regeneration. A collagen matrix was functionalized with the addition of poly-lactic-co-glycolic acid microcarriers (PLGA-MCs) carrying a human Transforming Growth Factor β1 (hTFG-β1) payload, to provide a 3D biomimetic environment with the capacity to direct stem cell commitment towards a chondrogenic phenotype. PLGA-MCs (mean size 3 ± 0.9 μm) were prepared via supercritical emulsion extraction technology and tailored to sustain delivery of payload into the collagen hydrogel for 21 days. PLGA-MCs were coseeded with human Bone Marrow Mesenchymal Stem Cells (hBM-MSCs) in the collagen matrix. Chondrogenic induction was suggested when dynamic perfusion was applied as indicated by transcriptional upregulation of COL2A1 gene (5-fold; p < 0.01) and downregulation of COL1A1 (0.07-fold; p < 0.05) and COL3A1 (0.11-fold; p < 0.05) genes, at day 16, as monitored by qRT-PCR. Histological and quantitative-immunofluorescence (qIF) analysis confirmed cell activity by remodeling the synthetic extracellular matrix when cultured in perfused conditions. Static constructs lacked evidence of chondrogenic specific gene overexpression, which was probably due to a reduced mass exchange, as determined by 3D system Finite Element Modelling (FEM) analysis. Proinflammatory (IL-6, TNF, IL-12A, IL-1β) and anti-inflammatory (IL-10, TGF-β1) cytokine gene expression by hBM-MSC was observed only in dynamic culture (TNF and IL-1β 10-fold, p < 0.001; TGF-β1 4-fold, p < 0.01 at Day 16) confirming the cells’ immunomodulatory activity mainly in relation to their commitment and not due to the synthetic environment. This study supports the use of 3D hydrogel scaffolds, equipped for growth factor controlled delivery, as tissue engineered models for the study of in vitro chondrogenic differentiation and opens clinical perspectives for injectable collagen-based advanced therapy systems.
Mechanical Properties of GFRPs Exposed to Tensile, Compression and Tensile–Tensile Cyclic Tests
Authors: Stanciu Mariana Domnica , Drăghicescu Horațiu Teodorescu , Roșca Ioan Călin
Published: March 2021

Currently there are many applications for the use of composites reinforced with fiberglass mat and fabrics with polyester resin: automotive, aerospace, construction of wind turbines blades, sanitary ware, furniture, etc. The structures made of composites have a complex geometry, can be simultaneously subjected to tensile–compression, shear, bending and torsion. In this paper we analyzed the mechanical properties of a polyester composite material reinforced with glass fiber (denoted GFRP) of which were carried out two types of samples: The former contains four layers of plain fabric (GFRP-RT500) and the second type contains three layers of chopped strand mat (GFRP-MAT450). The samples were subjected to tensile, compression and tensile–tensile cyclic loading. The results highlight the differences between the two types of GFRP in terms of initial elastic modulus, post yield stiffness and viscoelastic behavior under cyclic loading. Thus, it was observed that the value of the modulus of elasticity and the value of ultimate tensile stress are approximately twice higher in the case of GFRP-RT500 than for the composite reinforced with short fibers type GFRP-MAT450. The tensile–tensile cyclic test highlights that the short glass fiber-reinforced composite broke after the first stress cycle, compared to the fabric-reinforced composite in which rupture occurred after 15 stress cycles. The elasticity modulus of GFRP-RT500 decreased by 13% for the applied loading with the speed of 1 mm/min and by 15% for a loading speed of 20 mm/min.
New Insights into Antibacterial and Antifungal Properties, Cytotoxicity and Aquatic Ecotoxicity of Flame Retardant PA6/DOPO-Derivative Nanocomposite Textile Fibers
Authors: Vasiljević Jelena , Štular Danaja , Kalčíková Gabriela , Zajc Janja , Šobak Matic , Demšar Andrej , Tomšič Brigita , Simončič Barbara , Čolović Marija , Šelih Vid Simon , Jerman Ivan
Published: March 2021

The aim of this study was to evaluate the antibacterial and antifungal activity, cytotoxicity, leaching, and ecotoxicity of novel flame retardant polyamide 6 (PA6) textile fibers developed by our research group. The textile fibers were produced by the incorporation of flame-retardant bridged 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO) derivative (PHED) in the PA6 matrix during the in situ polymerization process at concentrations equal to 10 and 15 wt% (PA6/10PHED and PA6/15PHED, respectively). Whilst the nanodispersed PHED provided highly efficient flame retardancy, its biological activity led to excellent antibacterial activity against Escherichia coli and Staphylococcus aureus, as well as excellent antifungal activity against Aspergillus niger and Candida albicans. The results confirmed leaching of the PHED, but the tested leachates did not cause any measurable toxic effect to the duckweed Lemna minor. The in vitro cytotoxicity of the leached PHED from the PA6/15PHED sample was confirmed for human cells from adipose tissue in direct and prolonged contact. The targeted biological activity of the organophosphinate flame retardant could be beneficial for the development of PA6 textile materials with multifunctional properties and the low ecotoxicity profile, while the PHED’s leaching and cytotoxicity limit their application involving the washing processes and direct contact with the skin.
Immobilization of Caraway Essential Oil in a Polypropylene Matrix for Antimicrobial Modification of a Polymeric Surface
Authors: Strasakova Monika , Pummerova Martina , Filatova Kateryna , Sedlarik Vladimir
Published: March 2021

This study investigates antibacterial polymer composites based on polypropylene as modified by caraway essential oil at various concentrations, the latter immobilized on a talc. The caraway essential oil is incorporated in the polypropylene by a thermoplastic processing method. Analysis of the morphology of the composites was carried out by scanning electron microscopy. The chemical composition of the caraway essential oil in addition to its efficiency of incorporation and release were evaluated by GC/MS and Pyrolysis-GC/MS techniques, respectively. Determination was made as to the influence of such incorporation on thermal and tensile properties of the samples, while antibacterial activity was evaluated through conducting disk diffusion tests and measurement with adherence to the ISO 22196:2011 standard. It was found that incorporating the caraway essential oil in the samples did not affect the homogeneity of the thermoplastic-processed composites at any studied concentration. Stress–strain analysis confirmed the plasticizing effect of the essential oil in the polypropylene matrix, in addition to which, differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) analysis revealed that the prepared compositions with essential oil exhibited similar thermal properties to neat polypropylene. Results indicated significant antibacterial activity against Staphylococcus aureus and Escherichia coli at the concentration of essential oil of 4.9 ± 0.2 wt% and higher.
Shear Bond Strength of Veneered Zirconia Repaired Using Various Methods and Adhesive Systems: A Comparative Study
Authors: Habib Syed Rashid , Bajunaid Salwa , Almansour Abdulrahman , AbuHaimed Abdulkarim , Almuqrin Muqrin Nasser , Alhadlaq Abdullah , Zafar Muhammad Sohail
Published: March 2021

The aim of the present study was to investigate the shear bond strength of five different repair methods and adhesive systems for zirconia (Zr) cores layered with feldspathic porcelain. Seventy-five Zr specimens (10 × 10 × 4 mm3) were prepared, sintered, layered with 2 × 10 × 10 mm3 of feldspathic porcelain, and fired. The ceramic was fractured, and the load recorded using a shear-bond test. Specimens were thermocycled and randomly divided into 5 groups (n = 15/group) based on the repair methods. Composite repair blocks with similar dimensions to the layered ceramic (2 × 10 × 10 mm3) were built according to each repair method. Shear bond strength testing of the specimens with composite built up was carried out using a universal testing machine (Instron®5960, Massachusetts, USA). The shear bond strengths of the adhesive interface between repaired composite and the Zr were recorded for all the test groups. The fractured specimens’ surfaces were examined under a scanning electron microscope (Jeol, Musashino, Akishima, Tokyo, Japan) for evaluation of the type of failure and surface characteristics. Shear bond strength of the veneered ceramic bonded to the Zr for all the test groups was non-significant (ANOVA, p = 0.062). Shear bond strength after the repair revealed significant differences (ANOVA, p = 0.002). Group-C (13.79 ± 1.32) and Group-D (9.77 ± 4.77) showed the highest and lowest shear bond strength values, respectively. Paired Sample T-tests showed significantly lower values (p = 0.000) for the repaired (composite) Zr compared to the layered (ceramic) Zr. Multiple comparisons revealed differences (significant) between the shear bond strength of Group-D with Groups A (p = 0.010) and C (p = 0.003, Post Hoc Tukey test). The repair methods tested showed variations in their respective shear bond strengths. Complete ceramic/zirconia repair systems showed better bonding between the repaired composite and Zr core. The mean shear bond strength for the repaired fractured layered Zr showed acceptable outcomes in terms of clinical perspective, but was, however, unpredictable.
The Influence of Polyanions and Polycations on Bacteriophage Activity
Authors: Musin Egor V. , Kim Aleksandr L. , Dubrovskii Alexey V. , Kudryashova Ekaterina B. , Ariskina Elena V. , Tikhonenko Sergey A.
Published: March 2021

Phage therapy is a great alternative to antibiotic drugs, but it can’t effectively overcome the over-acidic medium of the stomach. We offer the use of polyelectrolyte microcapsules as a protective means of bacteriophage. It is necessary to understand the influence of polyelectrolytes on bacteriophage survival. The work studied the effect of polyanions and polycations on the coliprotetic bacteriophage’s viability. We have shown that polyallylamine decreased bacteriophage’s viability during increasing polyelectrolyte concentration and polyarginine had a lower inhibitory effect (then PAH) on the activity of the bacteriophage due to polyelectrolyte concentration from 0.05 to 5 mg/mL. It was shown that the inhibition of the bacteriophage by polyallylamine had an electrostatic nature and the use of high ionic strength prevented the formation of the PAH-protein capsid complex. Polystyrene sulfonate does not affect bacteriophage viability during increasing polyelectrolyte concentration from 0.05 mg/mL to 1 mg/mL. Polystyrene sulfonate decreases the viability of bacteriophage from 5 mg/mL of polyelectrolyte concentration. Dextran sulfate inhibits bacteriophage activity at 20–30%. Dextran inhibits bacteriophage activity by 80% at diapason concentration from 0.05 to 5 mg/mL and loses the inhibition effect from a concentration of 5 mg/mL.
Polymers in Sensor and Biosensor Design
Authors: Ramanaviciene Almira , Plikusiene Ieva
Published: March 2021

The growing demand and need for new analytical instruments that are highly sensitive, fast, and user-friendly for detecting various analytes has opened up new possibilities and led to the development of novel sensors and biosensors [...]
Optimizing Aerosol Jet Printing Process of Platinum Ink for High-Resolution Conductive Microstructures on Ceramic and Polymer Substrates
Authors: Arsenov Pavel V. , Efimov Alexey A. , Ivanov Victor V.
Published: March 2021

Printing nano-ink with platinum nanoparticles to generate conductive microstructures for electronics on different types of substrates has gained increasing interest in recent years. To solve the problem of the low conductivity of platinum (Pt) nano-ink, we synthesized chemically pure Pt nanoparticles with sizes of 18.2 ± 9.0 nm by spark discharge method. A low toxic solvent, ethylene glycol with water, was used to ensure the aggregation stability of Pt nanoparticles. Polyvinylpyrrolidone was used as an adhesive additive and binder in the nano-ink. Narrow and conductive Pt lines were generated by aerosol jet printing technology. The resistivity of the Pt lines sintered at 750 °C on alumina substrate was found to exceed the bulk Pt by about 13%. Moreover, the Pt film fabricated on polymer substrates has demonstrated excellent mechanical flexibility in terms of twisting tests.
Enhancement of Mechanical and Barrier Property of Hemicellulose Film via Crosslinking with Sodium Trimetaphosphate
Authors: Zhao Yuelong , Sun Hui , Yang Biao , Fan Baomin , Zhang Huijuan , Weng Yunxuan
Published: March 2021

Hemicellulose is a kind of biopolymer with abundant resources and excellent biodegradability. Owing to its large number of polar hydroxyls, hemicellulose has a good barrier performance to nonpolar oxygen, making this biopolymer promising as food packaging material. Hydrophilic hydroxyls also make the polymer prone to water absorption, resulting in less satisfied strength especially under humid conditions. Thus, preparation of hemicellulose film with enhanced oxygen and water vapor barrier ability, as well as mechanical strength is still sought after. Herein, sodium trimetaphosphate (STMP) was used as esterification agent to form a crosslinked structure with hemicellulose through esterification reaction to render improved barrier performance by reducing the distance between molecular chains. The thus modified hemicellulose film achieved an oxygen permeability and water vapor permeability of 3.72 cm3 × μm × m−2 × d−1 × kPa−1 and 2.85 × 10−10 × g × m−1 × s−1 × Pa−1, respectively, at the lowest esterification agent addition of 10%. The crosslinked structure also brought good mechanical and thermal properties, with the tensile strength reaching 30 MPa, which is 118% higher than that of the hemicellulose film. Preliminary test of its application in apple preservation showed that the barrier film obtained can effectively slow down the oxidation and dehydration of apples, showing the prospect of application in the field of food packaging.
A Polymer Blend Electrolyte Based on CS with Enhanced Ion Transport and Electrochemical Properties for Electrical Double Layer Capacitor Applications
Authors: Aziz Shujahadeen B. , Dannoun Elham M. A. , Hamsan Muhamad H. , Ghareeb Hewa O. , Nofal Muaffaq M. , Karim Wrya O. , Asnawi Ahmad S. F. M. , Hadi Jihad M. , Kadir Mohd Fakhrul Zamani Abdul
Published: March 2021

The fabrication of energy storage EDLC in this work is achieved with the implementation of a conducting chitosan–methylcellulose–NH4NO3–glycerol polymer electrolyte system. The simple solution cast method has been used to prepare the electrolyte. The impedance of the samples was fitted with equivalent circuits to design the circuit diagram. The parameters associated with ion transport are well studied at various plasticizer concentrations. The FTIR investigation has been done on the films to detect the interaction that occurs among plasticizer and polymer electrolyte. To get more insights into ion transport parameters, the FTIR was deconvoluted. The transport properties achieved from both impedance and FTIR are discussed in detail. It was discovered that the transport parameter findings are in good agreement with both impedance and FTIR studies. A sample with high transport properties was characterized for ion dominancy and stability through the TNM and LSV investigations. The dominancy of ions in the electrolyte verified as the tion of the electrolyte is established to be 0.933 whereas it is potentially stable up to 1.87 V. The rechargeability of the EDLC is steady up to 500 cycles. The internal resistance, energy density, and power density of the EDLC at the 1st cycle are 53 ohms, 6.97 Wh/kg, and 1941 W/kg, respectively.
The Ideology Factor and Individual Disengagements from the Muslim Brotherhood
Authors: Menshawy Mustafa
Published: March 2021

Since 2011, there has been a growing wave of individuals leaving Egypt’s Muslim Brotherhood, and many of them have opted for documented publicity by writing autobiographies narrating their whole journey. This article explores the ideological components of the disengagement process on the basis of a frame analysis of these writings. It seeks to understand how individuals acted against some of the meanings central to the Brotherhood’s ideological character and influence. They construct sets of meanings negating or renegotiating those long fixated, sanctified and ineluctable parts of the group’s ideology. The process of meaning making is situated within the Arab Spring where the Brotherhood’s dominant ideology also suffered from ruptures, incongruence or dissonance. For example, many exiters realized that the group’s ideology is not ‘evolutionary’ enough to align with a ‘revolutionary’ moment in Egypt’s history, and it thus failed to provide them with a sense of meaning regarding the dramatically changing world around them. The disillusionment goes beyond a battle of textually-situated meanings between the Brotherhood and its disgruntled members during the process of their departure from it. It appertains to a context of new resources and opportunities made available to exiters to resist, challenge, and even falsify the dominant ideology without incurring heavy losses or harsh penalties often meted out by the group against its ‘dissidents’. The agency of exiters, i.e., their capacity to act against the group’s ideology or manifest their rebellion against its elements, is also enabled by the state’s relative tolerance towards the exiters, a degree of social assimilation inside Egypt, internal ideological and organizational divisions inside the Brotherhood and geographical re-spatialization.
Compassionate Deism and the Grammar of Permission
Authors: Hall Ronald
Published: March 2021

Both theism and atheism assume that God permits evil. But neither theism nor atheism make this assumption with due attention to what I call, following Wittgenstein, the grammar of the term ‘permission’. When this grammar is examined, it becomes clear that this assumption cannot avoid the atheistic force of the argument from evil. To rescue belief in God, I propose the adoption of a position I call compassionate deism. This position is a combination of Christian theism and traditional deism. The combination is produced by making a slight deistic modification of Christian theism in the direction of non-intervention, and a slight modification of deism in the direction of compassion. Such a compassionate deism denies the common assumption made by both Christian theism and atheism, namely, that God permits evil, and thus avoids the theistic denial of the reality of evil and the atheist’s denial of God’s goodness.
Using Aerial Photogrammetry to Assess Stock-Wide Marine Turtle Nesting Distribution, Abundance and Cumulative Exposure to Industrial Activity
Authors: Fossette Sabrina , Loewenthal Graham , Peel Lauren R. , Vitenbergs Anna , Hamel Melanie A. , Douglas Corrine , Tucker Anton D. , Mayer Florian , Whiting Scott D.
Published: March 2021

The lack of accurate distribution maps and reliable abundance estimates for marine species can limit the ability of managers to design scale-appropriate management measures for a stock or population. Here, we tested the utility of aerial photogrammetry for conducting large-scale surveys of nesting marine turtles at remote locations, with a focus on the flatback turtle (Natator depressus) in the Pilbara region of Western Australia. Aerial surveys were conducted between 29 November and 6 December 2016 to overlap with the peak nesting season for flatback turtles and collected imagery was used to examine marine turtle distribution, abundance, and cumulative exposure to industrial activity relative to overlap with protected areas. Two observers independently reviewed aerial georeferenced photographs of 644 beaches and recorded turtle tracks and other evidence of turtle nesting activity. A total of 375 beaches showed signs of nesting activity by either flatback, green (Chelonia mydas) or hawksbill (Eretmochelys imbricata) turtles. Most of these beaches (85.3%) were located on islands, and the rest (14.7%) on the mainland. Half (n = 174) of the active beaches showed evidence of fresh (0–36 h. old) flatback nesting activity, with track abundance varying from 1.0 to 222.0 tracks·night−1. Six rookeries accounted for 62% of the Pilbara flatback stock. Remarkably, 77% of identified flatback rookeries occurred within protected areas. However, one-third (34%) of those were also located within 5 km of a major industrial site, including eight of the highest abundance beaches (50–250 tracks·night−1). Several key rookeries were also identified as being relatively unexposed to industry-related pressures but currently unprotected, highlighting the need for a cumulative impact assessment to be completed for this flatback stock. Finally, our aerial tallies and multiple ground-survey flatback track tallies were highly correlated and together with low intra- and inter-observer errors suggested that reliable data can be collected via aerial photogrammetry for nesting marine turtles. Such large-scale digitized surveys can therefore be used to assess the cumulative exposure of marine turtles to pressures, and to reveal new conservation opportunities.
Reverse Thinking: A New Method from the Graph Perspective for Evaluating and Mitigating Regional Surface Heat Islands
Authors: Yu Zhaowu , Zhang Jinguang , Yang Gaoyuan , Schlaberg Juliana
Published: March 2021

Accurately locating key nodes and corridors of an urban heat island (UHI) is the basis for effectively mitigating a regional surface UHI. However, we still lack appropriate methods to describe it, especially considering the interaction between UHIs and the role of connectivity (network). Specifically, previous studies paid much attention to the raster and vector perspective—based on standard landscape configuration metrics that only provide an overall statistic over the entire study area without further indicating locations where different types of pattern and fragmentation occur. Therefore, by reverse thinking, here we attempt to propose a new method from the graph perspective which integrates morphological spatial pattern analysis (MSPA)—which is used to characterize binary patterns with emphasis on connections between their parts as measured at varying analysis scales, and habitat availability indices to evaluate and mitigate regional surface UHI. We selected the Pearl River Delta Metropolitan Region (PRDR), one of the most rapidly urbanized regions in the world as the case study (1995–2015). The results of the case study showed: (1) the core (UHI) type accounts for the vast majority of the MSPA model, with the relative land surface temperature (LST) rises, the proportion of the core type will increase, and it could influence the edge (UHI) type significantly; (2) the branch, bridge, and islet (UHI) types have similar results to the lower temperature (4 < Relative LST ≤ 6) area and account for the majority, indicating that these types are more susceptible to their surrounding environment; (3) the importance and extreme importance area (node) from 1995 to 2015 have increased significantly and mainly distributed in the urbanized areas, which means cooling measures need to be implemented in these areas in order of priority. Shifting the research logic of UHI evaluation and mitigation from “patch” to “network”, we hold the point that the method (reverse thinking) has significant theoretical and practical implications for mitigating regional UHI and urban climate-resilience.
Unsupervised Building Instance Segmentation of Airborne LiDAR Point Clouds for Parallel Reconstruction Analysis
Authors: Zhang Yongjun , Yang Wangshan , Liu Xinyi , Wan Yi , Zhu Xianzhang , Tan Yuhui
Published: March 2021

Efficient building instance segmentation is necessary for many applications such as parallel reconstruction, management and analysis. However, most of the existing instance segmentation methods still suffer from low completeness, low correctness and low quality for building instance segmentation, which are especially obvious for complex building scenes. This paper proposes a novel unsupervised building instance segmentation (UBIS) method of airborne Light Detection and Ranging (LiDAR) point clouds for parallel reconstruction analysis, which combines a clustering algorithm and a novel model consistency evaluation method. The proposed method first divides building point clouds into building instances by the improved kd tree 2D shared nearest neighbor clustering algorithm (Ikd-2DSNN). Then, the geometric feature of the building instance is obtained using the model consistency evaluation method, which is used to determine whether the building instance is a single building instance or a multi-building instance. Finally, for multiple building instances, the improved kd tree 3D shared nearest neighbor clustering algorithm (Ikd-3DSNN) is used to divide multi-building instances again to improve the accuracy of building instance segmentation. Our experimental results demonstrate that the proposed UBIS method obtained good performances for various buildings in different scenes such as high-rise building, podium buildings and a residential area with detached houses. A comparative analysis confirms that the proposed UBIS method performed better than state-of-the-art methods.
The Root-Soil Water Relationship Is Spatially Anisotropic in Shrub-Encroached Grassland in North China: Evidence from GPR Investigation
Authors: Cui Xihong , Zhang Zheng , Guo Li , Liu Xinbo , Quan Zhenxian , Cao Xin , Chen Xuehong
Published: March 2021

To analyze the root-soil water relationship at the stand level, we integrated ground-penetrating radar (GPR), which characterized the distribution of lateral coarse roots (>2 mm in diameter) of shrubs (Caragana microphylla Lam.), with soil core sampling, which mapped soil water content (SWC) distribution. GPR surveys and soil sampling were carried out in two plots (Plot 1 in 2017 and Plot 2 in 2018) with the same size (30 × 30 m2) in the sandy soil of the semi-arid shrubland in northern China. First, the survey area was divided into five depth intervals, i.e., 0–20, 20–40, 40–60, 60–80, and 80–100 cm. Each depth interval was then divided into three zones in the horizontal direction, including root-rich canopy-covered area, root-rich canopy-free area, and root-poor area, to indicate different surface distances to the canopy. The generalized additive models (GAMs) were used to analyze the correlation between root distribution density and SWC after the spatial autocorrelation of each variable was eliminated. Results showed that the root-soil water relationship varies between the vertical and horizontal directions. Vertically, more roots are distributed in soil with high SWC and fewer roots in soil with low SWC. Namely, root distribution density is positively correlated with SWC in the vertical direction. Horizontally, the root-soil water relationship is, however, more complex. In the canopy-free area of Plot 1, the root-soil water relationship was significant (p < 0.05) and negatively correlated in the middle two depth intervals (20–40 cm and 40–60 cm). In the same two depth intervals in the canopy-free area of Plot 2, the root-soil water relationship was also significant (p < 0.01) but non-monotonic correlated, that is, with the root distribution density increasing, the mean SWC decreased first and then increased. Moreover, we discussed possible mechanisms, e.g., root water uptake, 3D root distribution, preferential flow along roots, and different growing stages, which might lead to the spatially anisotropic relationship between root distribution and SWC at the stand level. This study demonstrates the advantages of GPR in ecohydrology studies at the field scale that is challenging for traditional methods. Results reported here complement existing knowledge about the root-soil water relationship in semi-arid environments and shed new insights on modeling the complex ecohydrological processes in the root zone.
Sea Ice Concentration and Sea Ice Extent Mapping with L-Band Microwave Radiometry and GNSS-R Data from the FFSCat Mission Using Neural Networks
Authors: Llaveria David , Munoz-Martin Juan Francesc , Herbert Christoph , Pablos Miriam , Park Hyuk , Camps Adriano
Published: March 2021

CubeSat-based Earth Observation missions have emerged in recent times, achieving scientifically valuable data at a moderate cost. FSSCat is a two 6U CubeSats mission, winner of the ESA S3 challenge and overall winner of the 2017 Copernicus Masters Competition, that was launched in September 2020. The first satellite, 3Cat-5/A, carries the FMPL-2 instrument, an L-band microwave radiometer and a GNSS-Reflectometer. This work presents a neural network approach for retrieving sea ice concentration and sea ice extent maps on the Arctic and the Antarctic oceans using FMPL-2 data. The results from the first months of operations are presented and analyzed, and the quality of the retrieved maps is assessed by comparing them with other existing sea ice concentration maps. As compared to OSI SAF products, the overall accuracy for the sea ice extent maps is greater than 97% using MWR data, and up to 99% when using combined GNSS-R and MWR data. In the case of Sea ice concentration, the absolute errors are lower than 5%, with MWR and lower than 3% combining it with the GNSS-R. The total extent area computed using this methodology is close, with 2.5% difference, to those computed by other well consolidated algorithms, such as OSI SAF or NSIDC. The approach presented for estimating sea ice extent and concentration maps is a cost-effective alternative, and using a constellation of CubeSats, it can be further improved.
High-Resolution Gridded Population Datasets: Exploring the Capabilities of the World Settlement Footprint 2019 Imperviousness Layer for the African Continent
Authors: Palacios-Lopez Daniela , Bachofer Felix , Esch Thomas , Marconcini Mattia , MacManus Kytt , Sorichetta Alessandro , Zeidler Julian , Dech Stefan , Tatem Andrew J. , Reinartz Peter
Published: March 2021

The field of human population mapping is constantly evolving, leveraging the increasing availability of high-resolution satellite imagery and the advancements in the field of machine learning. In recent years, the emergence of global built-area datasets that accurately describe the extent, location, and characteristics of human settlements has facilitated the production of new population grids, with improved quality, accuracy, and spatial resolution. In this research, we explore the capabilities of the novel World Settlement Footprint 2019 Imperviousness layer (WSF2019-Imp), as a single proxy in the production of a new high-resolution population distribution dataset for all of Africa—the WSF2019-Population dataset (WSF2019-Pop). Results of a comprehensive qualitative and quantitative assessment indicate that the WSF2019-Imp layer has the potential to overcome the complexities and limitations of top-down binary and multi-layer approaches of large-scale population mapping, by delivering a weighting framework which is spatially consistent and free of applicability restrictions. The increased thematic detail and spatial resolution (~10 m at the Equator) of the WSF2019-Imp layer improve the spatial distribution of populations at local scales, where fully built-up settlement pixels are clearly differentiated from settlement pixels that share a proportion of their area with green spaces, such as parks or gardens. Overall, eighty percent of the African countries reported estimation accuracies with percentage mean absolute errors between ~15% and ~32%, and 50% of the validation units in more than half of the countries reported relative errors below 20%. Here, the remaining lack of information on the vertical dimension and the functional characterisation of the built-up environment are still remaining limitations affecting the quality and accuracy of the final population datasets.
A Machine Learning Method for Predicting Vegetation Indices in China
Authors: Li Xiangqian , Yuan Wenping , Dong Wenjie
Published: March 2021

To forecast the terrestrial carbon cycle and monitor food security, vegetation growth must be accurately predicted; however, current process-based ecosystem and crop-growth models are limited in their effectiveness. This study developed a machine learning model using the extreme gradient boosting method to predict vegetation growth throughout the growing season in China from 2001 to 2018. The model used satellite-derived vegetation data for the first month of each growing season, CO2 concentration, and several meteorological factors as data sources for the explanatory variables. Results showed that the model could reproduce the spatiotemporal distribution of vegetation growth as represented by the satellite-derived normalized difference vegetation index (NDVI). The predictive error for the growing season NDVI was less than 5% for more than 98% of vegetated areas in China; the model represented seasonal variations in NDVI well. The coefficient of determination (R2) between the monthly observed and predicted NDVI was 0.83, and more than 69% of vegetated areas had an R2 > 0.8. The effectiveness of the model was examined for a severe drought year (2009), and results showed that the model could reproduce the spatiotemporal distribution of NDVI even under extreme conditions. This model provides an alternative method for predicting vegetation growth and has great potential for monitoring vegetation dynamics and crop growth.
Graph Based Multi-Layer K-Means++ (G-MLKM) for Sensory Pattern Analysis in Constrained Spaces
Authors: Tao Feng , Suresh Rengan , Votion Johnathan , Cao Yongcan
Published: March 2021

In this paper, we focus on developing a novel unsupervised machine learning algorithm, named graph based multi-layer k-means++ (G-MLKM), to solve the data-target association problem when targets move on a constrained space and minimal information of the targets can be obtained by sensors. Instead of employing the traditional data-target association methods that are based on statistical probabilities, the G-MLKM solves the problem via data clustering. We first develop the multi-layer k-means++ (MLKM) method for data-target association at a local space given a simplified constrained space situation. Then a p-dual graph is proposed to represent the general constrained space when local spaces are interconnected. Based on the p-dual graph and graph theory, we then generalize MLKM to G-MLKM by first understanding local data-target association, extracting cross-local data-target association mathematically, and then analyzing the data association at intersections of that space. To exclude potential data-target association errors that disobey physical rules, we also develop error correction mechanisms to further improve the accuracy. Numerous simulation examples are conducted to demonstrate the performance of G-MLKM, which yields an average data-target association accuracy of 92.2%.
PL-TOON: A Low-Cost Experimental Platform for Teaching and Research on Decentralized Cooperative Control
Authors: Peters Andrés A. , Vargas Francisco J. , Garrido Cristóbal , Andrade Cristóbal , Villenas Felipe
Published: March 2021

In this paper, we present the development of a low-cost multi-agent system experimental platform for teaching, and research purposes. The platform consists of train-like autonomous agents equipped with local speed estimation, distance sensing to their nearest predecessor, and wireless communications with other agents and a central coordinator. The individual agents can be used for simple PID experiments in a classroom or laboratory setting, while a collection of agents are capable of performing decentralized platooning with cooperative adaptive cruise control in a variety of settings, the latter being the main goal of the platform. The agents are built from low cost components and programmed with open source software, enabling teaching experiences and experimental work with a larger number of agents that would otherwise be possible with other existing solutions. Additionally, we illustrate with experimental results some of the teaching activities that the platform is capable of performing.