bluuebunny/crossref_metadata_2025 huggingface dataset:
OBTENÇÃO DE PECTINA DO SUBPRODUTO DA INDÚSTRIA DE SUCO DA Citrus sinensis L.
Authors: Lavagnini Maria Gabriela , Chen Oscar Li Yang , Baraldi Ilton José , Ferreira Flavio Dias
Published: December 2024

Objetivo: avaliar a influência da temperatura (70, 80 e 90 °C), tempo de extração (80, 120 e 160 minutos) e logaritmo da concentração do ácido de extração (0,176, 1,176 e 2,176 mol.L-1) no rendimento de pectina utilizando ácido cítrico para a extração por hidrólise ácida dos subprodutos da indústria de suco da Citrus sinensis L. Métodos: O subproduto da laranja (casca, semente e bagaço) foi coletado, congelado, liofilizado e armazenado. A extração de pectina seguiu método adaptado de Zanella e Taranto (2015), usando mistura do subproduto com água (1:70), com concentração de ácido cítrico ajustada. A mistura foi agitada, centrifugada e, após adição de etanol, deixou-se em repouso para precipitação da pectina, que foi filtrada, lavada e seca até peso constante. Um Planejamento Fatorial Completo foi aplicado para avaliar o efeito de tempo, temperatura e concentração de ácido sobre o rendimento de pectina. Resultados: Os resultados indicam que o rendimento de pectina variou de 5,91% a 34,36%. A otimização de extração de pectina mostrou que a condição ótima foi temperatura de 70 °C, tempo de extração de 80 minutos e logaritmo da concentração de ácido de 2,176 mol.L-1. A única variável que apresentou influência nas condições analisadas foi o logaritmo da concentração de ácido, demonstrando que o rendimento de pectina é diretamente proporcional a concentração de ácido na solução de extração. Conclusão: O rendimento de pectina do subproduto da laranja variou entre 5,91% e 34,36%, sendo o máximo obtido a 70 °C, por 80 minutos, com ácido de concentração log 2,176 mol/L. A extração é favorecida por maior concentração de ácido cítrico e pH mais baixo.
HEPATOTOXICIDADE INDUZIDA POR MEDICAMENTOS: IMPACTO CLÍNICO – PARTE 2
Authors: Viana Catiane Costa , Praxedes Marcus Fernando da Silva , Martins Maria Auxiliadora Parreiras
Published: December 2024

Lesão hepática induzida por fármacos (LHIF) é definida como lesão hepática induzida por fármacos ou por plantas/ervas medicinais que levam a alterações dos testes do fígado ou sua disfunção com exclusão razoável de outras etiologias. Embora a real proporção de hepatopatias ocasionadas por fármacos seja desconhecida, sabe-se que essa é a primeira causa de suspensão da comercialização e de restrição de indicações terapêuticas de fármacos. A LHIF também é um importante problema de saúde, devido a sua natureza imprevisível, patogênese mal compreendida e potencial para causar resultados fatais. Os fatores de risco de LHIF estão associados a interações entre genética, susceptibilidade do hospedeiro, fatores ambientais, fatores não genéticos (idade, sexo, entre outros) e fatores relacionados ao fármaco. Quanto ao mecanismo de toxicidade, LHIF pode ser classificada em direta (intrínseca) ou idiossincrática, podendo apresentar-se de várias formas que se assemelham a outras formas de doenças hepáticas agudas e crônicas, o que dificulta seu diagnóstico. O diagnóstico das hepatopatias medicamentosas deve considerar um conjunto de exames clínicos e laboratoriais, evolução clínica após a suspensão do fármaco e no conhecimento dos fármacos que podem lesar o fígado. A prevenção de LHIF inclui vigilância, identificação de fatores de risco e monitoramento de enzimas hepáticas antes e durante o tratamento com fármacos hepatotóxicos. O farmacêutico pode contribuir com a prevenção de LHIF através de medidas de farmacovigilância, avaliação de prontuários e prescrições, participação em equipes multidisciplinares, entre outras.
Heat Propagation in Multiple Malignant Tumours using the Hyperthermia Therapy
Authors: Khairi Azhar Nur Maizaratul Hanisha , Ishkrizat Taib  , Martin Awaludin , Tajul Arifin Ahmad Mubarak , Kamarudin Mohamad Saddam , Roseman Amani Hanis
Published: December 2024

Cancer is a growing concern in Malaysia, with a significant increase in the number of breast cancer cases and deaths from 2007 to 2016. This study used computational fluid dynamics (CFD) to analyse heat application in breast tissue models by examining three tumour stages at 40°C, 45°C, 50°C, 55°C, and 60°C. The simulation was conducted using several models such as the energy equation, the k-epsilon viscous model, and the radiation surface-to-surface model. The SIMPLE method was used to solve the equations in this simulation. Findings reveal that larger tumours exhibit reduced heat penetration owing to their size, while smaller tumours, with higher surface-to-volume ratios, respond better to heat. The heat transfer coefficient increases with tumour size due to a greater surface area. Optimal treatment temperatures are identified between 40°C and 45°C, effectively treating tumours without harming healthy tissue. The Specific Absorption Rate (SAR) is a measure of the energy deposited in body tissues upon exposure to radiofrequency (RF) electromagnetic. The result showed that with an increase in the size and number of tumours, the SAR values increased. This result indicates that large tumours can absorb more energy, resulting in high SAR values. This trend was similar at all tested temperatures, thus indicating relation of characteristics of the tumours to their ability to absorb energy. In conclusion, this study successfully examined various models representing different stages of malignant breast tumours. This study investigated heat propagation and evaluated SAR values, providing insights into how tumour size and number affect energy absorption.
Real-Time Environmental Design Parameters and their Impact on the Performance of Passive Basin Solar Still: A Dynamic CFD Modeling Approach
Authors: Al-Zurfi Hazim Ali Sahib , Mohammed Aljabri Ghaith Jasim , Alkhazraji Ali Salh Sawadi , Shubbar Qasim Hammoodi Hassan
Published: December 2024

A computational fluid dynamics (CFD) approach was used in this work to investigate various design and environmental factors and their impact on the performance of passive basin solar stills (PBSS). This requires using the ANSYS software to build a sophisticated geometrical solar still model with the associated solar cells. The impact of solar cell configuration on energy optimization was determined by analyzing the developed system in both series and parallel configurations. Accuracy of simulation results was ensured in the model by introducing a meshing technique that consisted of>2 million components. The results (for static pressure analysis) indicated the absence of any high-pressure-induced strains after evaluating the performance metrics (static pressure, velocity, and energy distribution) for impact on the system using > 200 iterations; this suggests that the system design is balanced. Hence, the performance of solar stills can be improved by using new materials and design configurations as shown in this work. This study has improved knowledge of solar water desalination and other forms of renewable energy sources for related applications.
MHD Flow and Heat Transfer of Carreau Fluid with Radiation and Heat Source Effect
Authors: Konduru Venkateswara Raju , Narahari Ravi Babu , Poli Chandra Reddy , Battala Veera Sankar , Ravuri Mohana Ramana , Dandu Sridevi , Balaraju Madhumohana Raju Addepalli
Published: December 2024

This article investigates the effects of radiation and heat transfer in the context of Magnetohydrodynamic (MHD) flow of a Carreau liquid over a non-linearly shrinking sheet, using a numerical approach. To tackle the problem, the governing partial differential equations (PDEs) are appropriately transformed into a set of ordinary differential equations (ODEs). These resulting non-linear ODEs are then solved numerically using the fourth-order Runge-Kutta (R-K) method, accompanied by the shooting technique to ensure accuracy and convergence. The study reveals various significant physical characteristics such as the Prandtl number, Weissenberg number, radiation parameter, heat source, and magnetic parameter, all of which play critical roles in influencing the flow and heat transfer behavior. These characteristics are analyzed and presented graphically, providing a clear understanding of how different physical parameters affect the MHD Carreau liquid flow. The findings offer valuable insights into the dynamics of such systems under varying physical conditions, contributing to the broader understanding of heat and mass transfer in complex fluids.
Computational Study on Thermal Management of IC Chips with Phase Change Materials
Authors: Kurhade Anant Sidhappa , Bhambare Parimal Sharad , Siraskar Gulab Dattrao , Dixit Swati Mukesh , Purandare Pramod S. , Shital Yashwant Waware Shital Yashwant x
Published: December 2024

This paper presents an implicit transient numerical formulation for a novel passive thermal management system using minichannels to cool heterogeneous IC chips on a substrate board. The proposed design incorporates phase change materials (PCM) within minichannels situated around the periphery of the IC chips. By direct conduction from the substrate board, the PCM absorbs latent heat, facilitating its phase transition from solid to liquid, thereby enhancing the thermal cooling performance of the system. The study compares the thermal performance of three configurations: a system without PCM, a system with minichannel-coupled PCM, and an optimized single minichannel positioned near the heat source. The effectiveness of different PCMs, namely paraffin wax, N-Eicosane, and ATP 78, is also evaluated. Results indicate that N-Eicosane outperforms the other PCMs in providing effective cooling. Specifically, the implementation of N-Eicosane PCM results in a system temperature reduction from 53.234°C in the generic model to 51.520°C. This constitutes a significant temperature drop of 1.74°C compared to the generic model, with an additional reduction of 0.5°C and 1.35°C when compared to paraffin wax and ATP 78 PCM, respectively.
The Impact of Variable Viscosity and Variable Thermal Conductivity on the Mixed Convective Flow of Casson Nanofluid in a Channel with Chemical Reaction
Authors: Havaleppanavar Bhuvaneshwari Rudrappa , Mohiuddin Syed , Tuljappa Anita , Prasad Mallappanavara Karuna , Meera Dudekula Shaik
Published: December 2024

A theoretical analysis has been conducted on the mixed convective Casson nanofluid flow in a vertical channel that contains a first-order chemical reaction. The energy equation takes into account the combined effects of variable viscosity and variable thermal conductivity and the viscous dissipation. Nanofluids have different nanoparticles such as Aluminum oxide (), Copper (), Silver (), Titanium oxide () and Iron oxide () are suspended nanoparticles in water () and Ethylene Glycol () as base fluids. The governing equations are solved by perturbation method analytically like the momentum, energy, and diffusion equations, semi-numerically using differential transform method and numerically using BVP5C method. The obtained numerical values are agreed well for all the three methods and is shown in tabular form. For each of the several governing factors, the contours of velocity, temperature, and concentration are shown graphically. Additionally, data is tabulated for skin friction, Nusselt number. The results found that the silver nanoparticles enhance the thermal conductivity considerably in the flow. The variable viscosity regulates the flow while the variable thermal conductivity suppresses the flow.
Dual Solutions of Two-Dimensional Hybrid Nanofluid Flow and Heat Transfer Past a Porous Medium Permeable Shrinking Sheet with Influence of Heat GenerationAbsorption and Convective Boundary Condition
Authors: Asghar Adnan , Govindarajoo Mallika Vasugi , Zaimi Khairy , Ibrahim Haslinda , Lund Liaquat Ali
Published: December 2024

In this study, the dual solutions of two-dimensional hybrid nanofluid flow and heat transfer past a porous medium permeable shrinking sheet with influence of heat generation/absorption and convective boundary condition were examined using the bvp4c solver with the MATLAB computational framework. The utilization of two-dimensional hybrid nanofluid flow and heat transfer in the presence of a porous medium permeable shrinking sheet, considering the effects of heat generation/absorption and convective boundary conditions, has wide-ranging applications in industries such as cooling systems, aerospace, chemical engineering, biomedical applications, energy systems, microfluidics, automotive thermal management, industrial drying, and nuclear reactor cooling, etc. These applications employ the improved thermal characteristics of hybrid nanofluids and the efficient heat control offered by porous media and convective boundary conditions. The governing partial differential equations (PDEs) are transformed into a collection of higher-order ordinary differential equations (ODEs) together with their corresponding boundary conditions. These equations are subsequently shown both numerically and graphically. The main objective of this inquiry is to examine the relationship between the solid volume fraction of copper and the permeability parameter of the porous medium, specifically focusing on the values of f''(0) and - (0) according to the suction effect. The current research has also integrated the temperature and velocity profile of a hybrid nanofluid flow, which corresponds to the influence of porous medium permeability, heat generation/absorption, and convective boundary condition. Dual solutions are acquired by certain combinations of parameters. Non unique solutions are obtained when the critical point reaches , for suction effects. Increasing the intensity of heat generation absorption and convective boundary condition leads to a more pronounced temperature profile and thicker boundary layer.
Magnetohydrodynamic Boundary Layer Flows over a Moving Porous Vertical Plate with Viscous Dissipation and Dufour Effects in the Presence of Heat Source and Chemical Reaction
Authors: Mangamma Chatla , Malga Bala Siddulu , Kumar Peddapatlolla Pramod , Appidi Lakshmi , Suresh Pallerla , Ravi Phanimukla Sayagoud
Published: December 2024

This study examines the impacts of a heat source, chemical reaction parameter, and viscous dispassion on magnetohydrodynamic flow in the boundary layer of an incompressible fluid across a moving porous vertical plate. A transition of similarities changed the governing Ordinary differential equations obtained from PDE. A numerical solution is obtained by utilizing Shooting techniques and the fourth-order Runge-Kutta integration strategy. Graphical analysis is used to examine how physical characteristics effect the profiles of concentration, temperature, and velocity. Mass transfer, heat transmission, and skin friction are shown in tabular form.
Solar Photovoltaic Surface Cooling Using Hybrid Solar Chimney-Collector with Wavy Fins
Authors: Genge Zhang , Misaran Mohd Suffian , Zhang Zikuan , Radzali Mohd Adzrie , Ismail Mohd Azlan
Published: December 2024

Elevated temperatures, frequently observed in regions characterized by high ambient heat, markedly diminish the operational efficiency and curtail the lifespan of Solar Photovoltaic (PV) panels. Consequently, it is essential to enhance the sustainability and operational performance of solar energy systems through the mitigation of surface temperatures of solar PV panels. The study investigates the impact of the number of fins on the panel's surface temperature and the airflow within the collector-chimney cavity. Computational Fluid Dynamics (CFD) simulations were employed to determine the optimal number of fins for maximum cooling efficiency. The results indicate that increasing the number of fins initially lowers the solar PV surface temperatures, but the improvements diminish due to increased airflow restrictions. The surface temperature reduction enabled by the fins up to 14.1°C at 50.99°C, which can help mitigate solar PV efficiency losses in hot climates. The CFD simulations accurately predicted the thermal-fluid behaviour and cooling capacity of the hybrid system, as validated against experimental data. The study concludes that the incorporation of optimized wavy cooling fins in a hybrid solar chimney-collector system shows strong potential for passively enhancing solar PV panel cooling and efficiency.
Effects of Heat Transfer on Combustion Characteristics in a Cylindrical Vortex Combustor
Authors: Kamarudin Mohd Fathurrahman , Mohd Nawi Mohd Al-Hafiz , Roslan Azri Hariz , Abd Latif Muhammad Lutfi , Jaafar Hazrin Jahidi , Mohd Hanid Mohd Hazwan , Danish Mohd
Published: December 2024

A vortex flows in micro/meso scale combustors for small-scale power generation play a crucial role in enhancing combustion efficiency and stability. They enhance mixing between fuel and air, promoting better combustion and help stabilize flames by maintaining consistent fuel-air ratios. The temperature are significantly impacts the reactant temperature due to heat conduction wall in Cylindrical Vortex Combustor (CVC). This phenomenon, known as preheating, occurs as the wall transfers heat to the reactants. ANSYS Fluent software is used for conducted a numerical investigation on a CVC. The combustor was characterized by a prescribed mass flow rate of 40 mg/s and an equivalence ratio (j) ranging from 0.5 to 1.5. Our analysis aimed to understand the combustion behavior within this confined geometry, considering factors such as heat loss and temperature behavior. The numerical findings indicate that elevated equivalence ratios correlate with the highest flame temperature in micro-combustion. Specifically, at an equivalence ratio of j=0.5, the flame temperature remains consistently low compared to the higher value of j=1.5. However, when accounting for wall temperature effects, the maximum flame temperature occurs at an equivalence ratio of j=1.3. The heat dissipation region is quite limited, especially at low equivalence ratio. In summary, heat transfer in cylindrical vortex combustors (CVC) contribute to reliable and efficient power generation, making them essential for portable energy systems.
A Comprehensive Review of Recent Advances in Scalar Convection- Diffusion Studies
Authors: Abdullah Aslam , Mohd Yunos Siti Nur Mariani , Basuno Bambang
Published: December 2024

Scalar convection-diffusion has been drawing attention in fluid mechanics since more than half a century due to its relevance in various applications, its impact on transport properties, and its interplay with other fluid phenomena. In this review, we summarize the recent advances in scalar convection-diffusion studies documented by various researchers in efforts to identify an appropriate case study for using the model of convection-diffusion correctly. Scalar convection-diffusion studies are classified as theoretical, numerical solution, extracellular, chemical reaction, turbulence, diffusivity, and mixing perspectives since different perspectives have their own context. This paper has examined and articulated a range of viewpoints with different emphases. Encapsulating the latest advancements in the study of scalar convection-diffusion processes for future case study applications is the goal of this review.
Numerical Simulation on Flow and Heat Transfer Characteristics of a Single-loop Oscillating Heat Pipe with Variable Pipe Diameter Ratios
Authors: Lu Hongkun , Mat Noor Muhamad , Shuigen Ning , Kadirgama Kumaran
Published: December 2024

A three-dimensional numerical model, employing the Volume of Fluid (VOF) method, was developed for a single-loop oscillating heat pipe (OHP) with variable diameters. The investigation explored the impact of varying pipe diameter ratios on flow and heat transfer characteristics at different operational stages under a 40W heat power. The results reveal that the diameter ratio significantly affects the spatial arrangement of the evaporation, adiabatic, and condensation sections in the OHP. In the initial stage, the condensation section displays 15 liquid slugs when the diameter ratio is 1, but this number decreases to fewer than 10 in the same area when the diameter ratio exceeds 1. Comparative to a straight-pipe OHP, configurations with varying diameter ratios exhibit a marginal reduction in the average fluid velocity during the circulation of the working fluid inside the pipe, with the most pronounced velocity decrease occurring at a diameter ratio of 0.8. As the diameter ratio increases to 1.25 and 1.5, the turbulent disturbances in the region where the working fluid flows from the adiabatic section to the evaporation or condensation section intensify, facilitating the temperature exchange within the OHP. During stable operation of the OHP, the frequency of temperature oscillations increases with an increasing diameter ratio, while the amplitude decreases. Among all the cases, the OHP with a diameter ratio of 1.25 has the optimal heat resistance, 1.50K/W. The heat transfer performance of the OHP with a pipe diameter ratio of 0.8 deteriorated, and the thermal resistance increased by 27.6% compared with the straight-pipe OHP.
Psychological help preferences test and motivation of Ukrainian veterans with the use of designed questionnaire and Zeigarnik Effect
Authors: VORONIN Mykola
Published: December 2024

In the article a new test to investigate preferences of Ukrainian veterans in receiving psychological help was presented. It is designed by war veteran young scientist to be as simple as possible for veterans not to consume their time. Named “10 Voronins’ Questions” (10VQ). It is also designed to motivate veterans think of help to prevent suicides by the means of Zeigarnik effect. Pilot study based on 43 randomly tested Ukrainian war veterans is also introduced. Possible advantages of this method are briefly presented and analyzed.
Formation of the professional readiness of future psychologists in the conditions of distance learning
Authors: SERGIYENI Olenа
Published: December 2024

The main objectives of modern higher education are stipulated by the formation of a professionally competent, socially active, creative, patriotically oriented personality that can be competitive both on the domestic and European labor markets. The work presents modern requirements for the professional readiness of future psychologists in connection with the challenges posed by the emergency situation of military operations in Ukraine and the need to provide differentiated psychological assistance to different segments of the population in the conditions of using the distance learning. The theoretical review of the scientific literature on the problem made it possible to identify the main components of a psychologist's readiness for professional activity. A selection of psycho-diagnostic methods was carried out, which made it possible to determine the components of a psychologist’s readiness for professional activity. The complex of psychodiagnostic methods was in line with the purpose of the study and can be used in research and practical work. The study can be continued on the contingent of master psychologists to determine their readiness for scientific, teaching and practical activities.
Transformation of student identity in the conditions of geopolitical challenges increased by the war
Authors: HAPONENKO Larysa
Published: December 2024

The author's approach is proposed in the analysis of the transformation of the personal identity of students who became forcibly displaced. 172 students took part in the survey. The theoretical analysis of the obtained empirical materials was based on the concept of W. James about the consciousness and awareness of one's own Ego by classes: material Ego, social Ego, spiritual "mine". The hierarchical sequence of identity transformation in the sequence "Ego's material identity - Ego's social identity - Ego's spiritual identity" is established as processes of transformational changes at a higher level. A formulaic definition of "identity transformation."
Directions for improving the distance teaching of mathematics in Ukraine under the conditions of marital state
Authors: MORMUL Mykola , SHCHYTOV Dmytro , SHCHYTOV Olexandr , ROMANCHUK Lyubov , CHUPILKO Tetjana
Published: December 2024

Distance education using information technologies – one of the modern forms of education – has gained special importance and development under the war conditions in which Ukraine is now. The article examines modern platforms designed for this type of training, the advantages and disadvantages of distanceeducation, and also makes a number of proposals that will help improve the process of preparing and conducting classes in distance form.
Education as a means of rehabilitation and adaptation to peaceful life of combatants
Authors: BONDARENKO Kateryna
Published: December 2024

The article is devoted to post-traumatic stress disorders among military veterans and their rehabilitation and adaptation to civil life. Guarantees of social benefits to military veterans in the sphere of higher and professional education, enshrined in the Ukrainian legislation, are presented. The article examines the international experience in other countries, namely, in the United States regarding programs of social benefits for military veterans. Statistical data on the number of participants in rehabilitation programs in Ukraine and the USA are presented. The problem of rehabilitation and adaptation of military veterans to civil life has risen in Ukraine recently, and therefore, requires further research.
Problems of higher education during the war (during the anti-terrorist operation in Donbas)
Authors: PIVEN Natalia
Published: December 2024

The article says about the higher education challenges during the war period (particularly, in the context of anti-terrorist operation prosecution in Donbass), as well as possibilities and difficulties the youth face with, regarding this factor. The author analyses the situation concerning the chances of getting higher education under the hybrid war conditions in the east of Ukraine, and estimate the activity of Educational center “Donbass-Ukraine” based in Priasovsk State Technical University. Besides, the article raises the issue of curative opportunities of education for the psychic of adolescents outlived the war.
Higher education as a means of overcoming Post-Traumatic Stress Disorder in war conditions
Authors: SHYYKA Svitlana
Published: December 2024

The article is devoted to the study of organizational, pedagogical and humanitarian potential of higher education as a means of overcoming post traumatic stress in war conditions. The interpretation of the main concepts of "stress", "stress", "post-traumatic stress", "post-traumatic stress disorder", and the symptoms of post-traumatic stress state are given. It is emphasized that the attraction of internally displaced people to higher education simultaneously solves such important tasks as overcoming the consequences of post-traumatic stress, psychological stabilization of the individual, its socialization, adaptation to life in new conditions, training of the future qualified specialist and citizen. The complex of measures ensuring successful fulfillment of these tasks is highlighted, among them: solving of material and domestic and organizational and pedagogical problems, design of educational, cognitive and educational activity on the basis of information of psychological and pedagogical diagnosis, creation of favorable social and psychological environment, formation of interpersonal relationships on principles of Ukrainian morals, language and mentality, active involvement of young people in public work, including student selfgovernment, personal a well-orientated approach to the learning process, the effective use of the content of academic disciplines, the application of promising teaching methods and assessment of academic achievement, the involvement of students in virtual e-communication, participation in thematic programs and projects. The result of the pedagogical process is to become a psychologically balanced, adapted to the new conditions of a person's life, and at the same time - a competent specialist.
Psychological culture of the teacher in the conditions of information war
Authors: BOYKO Iryna
Published: December 2024

This article includes the actual problem of informational security of the individual, the roles of psychological culture of individuals of the learning process in the context of the formation and development of the informational society. The aim of the work is to disclosure of extremely common issues of psychological research on the content of the psychological and professional work of teachers, which is implemented solution to the problem study and find ways to improve disclosure of potential humanistic psychology in education, in particular the formation of the individuals of the learning process of psychological culture as propedeutics of negative aggressive information effects on mental health. The main goal is to find solutions to problems identified regarding the formation of all individuals of the learning process competence in the field of informational security, data protection and a secure educational environment; highlight areas of teacher information and components of informational security threats subjects of the educational process. The methodological framework for the analysis of problems of psychological culture, forming the basic concepts are considered in this article . Such main concepts as: information war, internet addiction, informatization of education, psychological culture, a safe educational environment are characterized and analyzed. In further studies, the next step in highlighting the problems of formation of psychological culture lies in the informational security, theoretical and practical solution of issues, among which the greatest urgency and determination becomes a secure informational environment; Information detailing the content of the educational activities of a teacher in today's informational society to improve teacher knowledge of psychological mechanisms forms and methods of informational influence and informational suppression; forming a teacher's ability to navigate the flow of information, identify the hidden potential threats related to the selection, evaluation and protection of information prohibited for distribution to children; mastery of knowledge and methods of protection from criminal and terrorist information in various information flow, mastering the techniques of informational security educational institution and the individual.
Professional training of the students-psychologists for working with children of war
Authors: LYTVYNENKO Iryna , HOTENOV Ihor
Published: December 2024

In the article there is discussed the problem of professional training of future psychologists for work with junior school children who have outlived a psychotraumatic situation. This situation concerns the fights in the East of the country and the children have moved to safer regions with the irparents. There is examined category of school children, there are found some “weak” section in the educational process. There are presented the ways of the improvement of the professional training of future psychologists with the accent on the practically-orientated study considering the conditions in which the state of Ukraine, the defense of the society, the system of education, especially the system of primary school, are functioning.
Persepsi Nilai dan Niat Pembelian pada Layanan Premium : Studi kepada para Gamers di Indonesia
Authors: Wilia Tri Tata , Kurnia Sari Dessy , Lenggogeni Sari
Published: December 2024

This study focuses on the perceived value of premium games among users and its impact on usage and premium content purchase intentions. The research aims to explore how social value, quality, enjoyment, and economic value influence users’ willingness to continue using the service and purchase premium content. Using an online survey method through Google Forms with 150 respondents, the study found that the higher the level of enjoyment in the premium service, the lower the intention to purchase premium content, but it strengthens the intention to continue using the service. Other findings show that social value increases both premium usage and premium purchase intentions. Additionally, service quality has a positive correlation with usage intention, but does not affect premium purchases. Overall, the results of this study highlight the unique characteristics of the premium business model in enhancing user retention through high perceived value, although challenges remain in premium monetization.
Studi Komparatif Proses Pendaftaran Merek Terkenal Milik Perusahaan X di Negara Anggota World Trade Organization
Authors: Sihite Jelita Damai Sofia Lorenza , Lie Gunardi
Published: December 2024

Merek adalah ciri khas dari suatu produk atau layanan. Perusahaan menggunakan merek dagang untuk memperluas penjualan mereka di pasar mulai dari nasional hingga internasional. Perusahaan X dari China telah berhasil mendaftarkan merek dagangnya di beberapa negara yang menjadi anggota World Trade Organisation, negara-negara dimana perusahaan X telah mendaftarkan merek dagangnya adalah Afrika Selatan, Moldova, Ekuador, Serbia, Kyrgyzstan dan Uni Eropa. Berdasarkan latar belakang tersebut timbul suatu isu, yaitu bagaimana proses pendaftaran merek yang dialami oleh Perusahan X? sedangkan masing-masing negara memiliki peraturan yang berbeda mengenai perlindungan merek. Tujuan dari penelitian ini adalah untuk mengetahui bagaimana pendaftaran merek terkenal di negara-negara anggota World Trade Organization. Metode penelitian yang digunakan dalam penelitian ini adalah yuridis normatif, dengan menggunakan Teknik pengumpulan data menggunakan Teknik studi kepustakaan (Library research) yang mana terdiri dari tiga bahan hukum yaitu bahan hukum primer, bahan hukum sekunder dan bahan hukum tersier. Bahan hukum primer terdiri dari Undang-Undang ataupun peraturan yang mengatur tentang merek yaitu, perjanjian TRIPS, Protokol Madrid, dan Konvensi Paris. Hasil dari penelitian ini adalah bahwa pada dasarnya semua negara anggota Organisasi Perdagangan Dunia yang melindungi merek X memiliki tujuan agar merek tersebut memiliki identitas yang berbeda dengan merek lain di kelas yang sama. Perbedaan juga ditemukan ketika menganalisis aturan di masing-masing negara, seperti proses pendaftaran, jangka waktu perlindungan, dan penyelesaian sengketa. Selain itu, ditemukan juga prinsip pendaftaran merek yang mengedepankan minim biaya pendaftaran, yaitu prinsip Single Application.
PENGARUH BAURAN PEMASARAN 4P TERHADAP MINAT BELI IKAN KERING DI UKM KELURAHAN OESAPA KOTA KUPANG
Authors: Bulan Melkianus Teddison , Amil Patricia Ardia , Sri Naharuddin
Published: December 2024

This study aimed to analyze the effect of the 4P marketing mix on buying interest in dried fish at UKM Bahar in Oesapa village. The type of research used in this study was quantitative. The population was all consumers who had bought fish at UKM Bahar in Oesapa village at least twice and had an age range of 17–50 years with accidental sampling, and the total sample was 68 people. The data analysis was multiple linear regression. The findings showed that product and promotion variables had a negative and significant effect on consumer buying in­terest, price, and placed variables had a positive and significant impact on con­sumer buying interest, and product variables had a dominant effect on consumer buying interest in dried fish at UKM Bahar in Oesapa village. The implications of this study provided direction for SMEs in Bahar Oesapa village to pay attention to product and promotion factors because both factors negatively influenced consu­mer buying interest. After all, it indicates that the decreasing quality of products and promotions reduced consumer buying interest, so there will be an increase in sales in the future. Penelitian ini bertujuan untuk menganalisis pengaruh bauran pemasaran 4P pada minat beli ikan kering di UKM Bahar kelurahan Oesapa. Jenis penelitian yang digunakan dalam penelitian ini adalah kuantitatif. Populasi dalam penelitian adalah semua konsumen yang pernah membeli ikan di UKM Bahar kelurahan Oesapa minimal dua kali dan memiliki kisaran umur 17–50 tahun dengan pengambilan sampel accidental sampling dan total sampel yang digunakan dalam penelitian ada­lah 68 orang. Analisis data yang digunakan adalah regresi linear berganda. Hasil temuan menunjukkan bahwa variabel produk dan promosi berpengaruh negatif dan signifikan pada minat beli konsumen, vari­abel harga dan tempat berpengaruh positif dan signifikan pada minat beli konsumen, dan variabel produk dominan berpengaruh pada minat beli konsumen ikan kering di UKM Bahar keluraharan Oesapa. Implikasi pe­ne­li­ti­an ini mem­be­ri­kan arahan bagi pihak UKM Bahar kelurahan Oesapa untuk memperhatikan faktor produk dan promosi sebab kedua faktor tersebut memiliki pengaruh negatif terhadap minat beli konsumen karena mengindikasikan bahwa semakin menurunnya kualitas produk dan promosi, maka menurunkan minat beli konsumen, sehingga di masa yang akan datang ada peningkatan penjualan.
Pilonidal Cyst of the Penis: Suggestion of a Management Plan Based on Literature Review and a Case Report
Authors: Kanafani Ahmad , Hammoud Ahmad , Bejjani Noha , Mahfoud Daniel , Youssef Nazih
Published: December 2024

Background: Pilonidal sinus rarely affects the penis. This disease is only discussed in case reports, around 26 cases in the literature, and never in textbooks or guidelines. Along with the scarce data in the literature, most of the reported cases were managed differently, and the diagnosis, which could only be confirmed with specimen histopathology, was delayed. Besides the case report of a rare penile disease, the purpose of this paper is to suggest a management plan for suppurative penile lesions to avoid delay in diagnosis and treatment.
Case Report: We encountered a case of penile pilonidal sinus that was initially treated as an abscess based on an ultrasound result. The quick relapse and the suspicious second ultrasound of a hair-like septum in the lesion led to excision and histopathologic confirmation. Penile swelling in patients with a history of Papaverine or any vasoactive drugs injections, trauma, penile prosthesis, diabetes mellitus, intra-abdominal abscess, Tuberculosis, intravenous drug abuse, systemic symptoms, and signs of infection should be managed as an abscess; drainage, appropriate antibiotherapy, and management of risk factors and causes.
Discussion: The usual clinical presentation of pilonidal disease of the penis consists of tender penile swelling, dyspareunia, and purulent discharge, as well as erectile dysfunction which was reported in only one case. In contrast to penile abscess, the presentation usually includes a tender penile swelling, and systemic symptoms such as fever, chills, and night sweats. Physical examination of this patient revealed a non-specific tender, pus-pointing, and pus-containing lesion with mildly erythematous edges, located near the coronal sulcus
Conclusion: Pilonidal cyst of the penis is a rare disease with delayed management in the literature because of misdiagnosis caused by confusion with penile abscess. Though ultrasound could narrow the differential diagnosis, the clinical presentation remains the cornerstone in differentiating between penile abscess and pilonidal sinus.
Association of the Apollo Wearable With Fatigue, Raynaud Phenomenon, and Quality of Life in Patients With Systemic Sclerosis: A Pilot Study
Authors: Hammaker Krista , Hu Haomin , Laffoon Maureen , Freno Leigh A. , Lafyatis Robert , Park Yongseok , Domsic Robyn T.
Published: December 2024

Objective

In patients with systemic sclerosis (SSc), fatigue is the highest-ranked symptom affecting quality of life (QOL), followed by Raynaud phenomenon (RP). We report results from a pilot study of the Apollo wearable device in patients with SSc.

Methods

Twenty-five adult participants with SSc, moderate fatigue, and RP were enrolled. Participants completed a 4-week intervention, during which they wore the Apollo device daily for a minimum of 15 minutes. The primary outcome was change on the Patient Reported Outcomes Measurement Information System Fatigue 13a (PROMIS Fatigue) at 4 weeks.

Results

After 4 weeks of using the Apollo wearable, participants reported less fatigue on the PROMIS Fatigue (P< 0.001) scale. The average daily number of RP attacks declined (P= 0.007), as did the Raynaud Condition Score (P= 0.007) after 4 weeks of use. Average device usage (2.87 hours/day) far exceeded the requested time, and no adverse events occurred. The PROMIS-29 subscores assessment demonstrated QOL improvement in physical function (P= 0.01), depression (P= 0.03), fatigue (P= 0.01), sleep disturbance (P= 0.002), and ability to participate in social roles and activities (P< 0.001). Significant improvements were also noted for depression (P= 0.004) and disability (P< 0.05) measures.

Conclusion

Use of the Apollo wearable for 4 weeks was associated with improvement in fatigue and RP symptoms in patients with SSc, with improved QOL measures, lower depression scores, and improved disability measures. Future studies should further test the efficacy of the Apollo wearable in these domains and QOL of patients with SSc. (ClinicalTrials.gov:NCT04854850)
Tocilizumab (TCZ) for Giant Cell Arteritis: Clinical Outcomes Following Relapses and TCZ Discontinuation Due to Adverse Events
Authors: Nagase Fumika N. , Fukui Sho , Takizawa Naoho , Yamaguchi Toshihiro , Oda Nobuhiro , Inokuchi Hajime , Ito Takanori , Watanabe Mitsuru , Suda Masei , Haji Yoichiro , Suyama Yasuhiro , Rokutanda Ryo , Minoda Masahiro , Nomura Atsushi , Uechi Eishi , Tamaki Hiromichi
Published: December 2024

Objective

Tocilizumab (TCZ) is effective for giant cell arteritis (GCA). However, little is known regarding treatment modification and clinical outcomes after unfavorable events such as GCA relapses or TCZ discontinuation due to adverse events (AEs).

Methods

This multicenter retrospective study included patients with GCA who initiated TCZ from 2008 to 2021 at 5 Japanese hospitals. GCA relapses and TCZ-related AEs were monitored for 2 years after TCZ initiation. In patients with GCA relapses, subsequent clinical courses, including relapse symptoms and treatment modification, were followed for 90 days after the relapses. Similarly, patients who discontinued TCZ because of AEs were additionally followed until 1 year after the TCZ discontinuation to evaluate AEs, relapses, and treatment changes.

Results

Of 62 eligible patients, 10 patients (16%) relapsed after initiating TCZ therapy. Most relapses (8 of 10) occurred after extending TCZ intervals or discontinuing TCZ. Combinations of adjusting TCZ intervals, adjusting glucocorticoid (GC) dose, and/or adding or increasing methotrexate (MTX) therapy could manage the relapses without serious complications. In the entire cohort, AEs occurred in 28 patients (45%), and 8 patients (13%) discontinued TCZ because of AEs. After AE-related TCZ discontinuation, 6 patients attempted to taper GCs without other immunosuppressive therapy (IST), and 4 subsequently relapsed. In contrast, 2 patients who used other IST or biologic therapy could decrease GCs without relapses.

Conclusion

Although GCA relapses can occur after initiating TCZ therapy, most relapses can be safely managed by adjusting TCZ, GC, and/or MTX doses. Adding IST or biologic treatments may potentially be related to preventing relapses when patients discontinue TCZ because of AEs.
Epidemiology of Isolated Cutaneous Lupus Erythematosus in the Multiethnic Population of Reunion Island: A Retrospective Multicenter Study
Authors: Maillet Mathurin , Tounkara Babacar S. , Vagner Damien , Bagny Kelly , Duquenne Sébastien , Lartigau-Roussin Céline , Kolbe Anne , Lauret Yves , Randrianjohany Andry , Laureau Serge , Denat Nicole , Alquier Aude , Sultan-Bichat Nathalie , Bertolotti Antoine , Raffray Loïc
Published: December 2024

Objective

Few data are available about the epidemiology of cutaneous lupus erythematosus (CLE) in the Southern hemisphere and in multiethnic populations. We describe the prevalence, incidence, and clinical characteristics of isolated CLE in the multiethnic population of Reunion Island, France, including patients with dark skin.

Methods

The study was performed in all public hospitals and private dermatology practices in Reunion Island. Cases were identified through informatics databases. Cases were defined as isolated CLE, meaning they did not fulfill the criteria for systemic lupus erythematosus (SLE). Incident cases were collected from 2008 to 2021. Prevalence was calculated on January 1, 2022. A capture-recapture analysis was performed to estimate both prevalence and incidence.

Results

A total of 268 cases of CLE were identified and 218 were incident cases. The standardized prevalence of CLE was 43 out of 100,000 persons and the average annual standardized incidence was 3.1 per 100,000 person-years (PY). With a capture-recapture analysis, prevalence and annual incidence were estimated to be 99 out of 100,000 persons (95% CI 77.10-136.45) and 5.7 per 100,000 PY (95% CI 4.40-7.95), respectively. The mean age at diagnosis was 41.7 years and the ratio of female to male individuals was 4:1. Patients with dark skin had a higher rate of discoid CLE and were more likely to receive immunosuppressants. Generalized discoid CLE, panniculitis, and overlapping subtypes of CLE appeared as predictive markers of progression toward SLE.

Conclusion

The prevalence and incidence of CLE in the multiethnic population of Reunion Island seem higher than in light-skinned populations. We highlight new risk factors of evolution toward SLE that should be known by practitioners to adjust follow-up.
Voščilo akademiku Francu Jakopinu ob osemdesetletnici
Authors: Cvetko Orešnik Varja
Published: December 2024

Voščilo akademiku Francu Jakopinu ob osemdesetletnici
Sedemdesetletnici Zvonke Leder - Mancini in Marte Silvester
Authors: Hajnšek-Holz Milena
Published: December 2024

Poleg osemdesetletnice rojstva akademika dr. Franca Jakopina, nekdanjega predstojnika Inštituta za slovenski jezik Frana Ramovša, letos praznujemo še sedemdesetletnici dveh slovarskih sodelavk: Zvonke Leder - Mancini in Marte Silvester.
O strukturi rojstnih imen v Sloveniji
Authors: Keber Janez
Published: December 2024

Razprava o strukturi rojstnih imen v Sloveniji, ki temelji na statističnih podatkih iz leta 1994, je sestavljena iz dveh delov. V prvem so po splošnem uvodu obravnavana zložena moška in ženska imena po abecednem redu njihovih sestavin. Pri tem so upoštevane tudi tuje imenske podstave, ki jim je dodana slovenska sestavina (npr. morfema -mir in -slav), a tudi nekatera druga, predvsem germanska zložena imena, ki so skupaj s tvorjenkami pri nas najbolj v rabi. V drugem delu so po uvodu, v katerem je govor o oblikovanju glasovne podobe rojstnih imen, obdelana moška in ženska imena glede na kon-čaje oziroma priponska obrazila. S slovenskimi sestavinami, morfemi in priponskimi obrazili so se izvorno tuja imena preoblikovala in se vključila v slovenski jezikovni in kulturni prostor.
La littérature antique entre les mains des élèves du XXIe siècle :des « stéréotypes » classiques en réception scolaire contemporaine ?
Authors: Fraterno Marlène
Published: December 2024

Encore au XXIe siècle, les élèves sont confrontés en cours de Français à de nombreuses œuvres antiques, qui constituent un socle de références à l’origine d’une culture commune qui permet de faire société. La littérature classique, présentée dans une perspective historique comme l’origine de la littérature occidentale – et pas seulement ! – est muséographiée dans les manuels, réaffirmant la place de figures littéraires d’autorité : des études ont montré qu’Homère était déjà surreprésenté dans les manuels et tablettes scolaires antiques... Cet article vise à interroger, à partir de ce constat, les raisons d’une telle cristallisation, encore aujourd’hui, malgré ou – paradoxalement – grâce au processus des lectures actualisantes : les extraits étudiés en contexte scolaire constituent-ils des morceaux choisis littéraires ou illustrent-ils des exempla axiologiques, antiques mais toujours valables en réception contemporaine ?