bluuebunny/crossref_metadata_2025 huggingface dataset:
A Participação no Fechamento de Mina no Direito Comparado
Authors: Ribeiro José Claudio Junqueira , Felisbino Mendes Samuel Santos
Published: December 2020

A participação da sociedade civil no fechamento de minas é crucial para a garantia de uma sustentabilidade abrangente, que contemple as diferentes visões acerca da efetivação do direito ao meio ambiente ecologicamente equilibrado. Este trabalho, a partir de uma pesquisa bibliográfica e documental, tem como objetivo identificar e analisar a legislação brasileira sobre fechamento de mina, avaliando os mecanismos de participação popular nesse processo, comparando-os com as formas de participação durante o processo de licenciamento ambiental, e com as normas de outros países com liderança global na atividade minerária. O licenciamento ambiental já prevê a participação das comunidades afetadas por empreendimentos geradores de significativo impacto ambiental, por meio de audiências públicas. Entretanto, no caso da mineração, verificou-se que esses instrumentos não têm sido suficientes para garantir a sustentabilidade após o fechamento das minas, havendo necessidade de novos ordenamentos jurídicos complementares, como demonstra as experiências nacional e internacional. AbstractThe civil society participation in mine closure is crucial to guarantee a broad sustainability, one that considers the different approaches on the right to a healthy environment. This work, from a bibliographic and documental research, intends to identify and analyze the mine closure Brazilian legislation, assessing the mechanisms of popular participation in this process, comparing them with the forms of participation in the environmental licensing process and with international legislation from other countries with global leadership in mining activity. The public hearing process is already present in the environmental licensing to grant the participation of communities affected by projects generating significant environmental impact. Nonetheless, as concluded in this study, this instrument has not been successful enough in mining activities, especially concerning sustainability in mine closure. For this reason, as shown by the national and international experience, new rules are necessary to grant the participation of affected communities.  KeywordsEnvironmental Licensing. Mine Closure. Participation Principle. Sustainable Development. Post Closure Sustainability.
TOWARDS A JURISPRUDENCE OF SUSTAINABILITY IN A TIME OF TRANSITION
Authors: Wade Jeffry S
Published: December 2020

In recent decades, an increasing number of disturbing trends have prompted many scientists and policy analysts to suggest that, as a species, we may be on the verge of a major transition or turning point.  Persistent negative trends in resource availability, biodiversity, environmental quality and human well-being indicate that the current global development model may be damaging Earth’s essential systems and processes beyond recovery.  Environmental law, as it exists in most countries, has not succeeded in controlling the impacts and effects of this development model.  A jurisprudence of sustainability is necessary, based on a set of principles that will ensure a more proactive, scientifically-based, integrated, communal and transparent approach to development regulation.
Direito ao Ambiente e o Direito à Moradia: Colisão e Ponderação de Direitos Fundamentais
Authors: Reis João Emilio de Assis
Published: December 2020

O presente trabalho é um ensaio teórico que trata de analisar o conflito entre o direito fundamental à moradia e o direito fundamental ao meio ambiente. Partindo da análise da evolução da incorporação da tutela da moradia e do ambiente ao ordenamento jurídico como direitos, analisa a presença de ambas como direitos fundamentais na Constituição de 1988. Partindo do pressuposto de inexistência de hierarquia entre ambos os direitos, busca finalmente apresentar o método da ponderação de valores e da concordância prática, como forma de solução de conflito entre direitos fundamentais. AbstractThis paper is a theoretical rehearsal that analyzes the conflict between the fundamental right to housing and the fundamental right to the environment. Based on the analysis of the evolution of the incorporation of housing and protection of the environment in the law, analyzes the presence of both as fundamental rights in the 1988 Constitution. Assuming absence of hierarchy between both rights, search finally present the method and the weighting of practical agreement as a way of resolving conflict between fundamental rights. KeywordsConflict of Fundamental Rights. Right to Environment. Right to Housing. Urbanization.
APRESENTAÇÃO
Authors: Rezende Elcio Nacur
Published: December 2020

Apresentação da Revista Veredas do Direito
Design cidadão: abordagens para a vivência urbana
Authors: Horta Anderson Antonio , Lins Cerqueira Clara Santana , Fernandes Batista Mylene , Da Conceição Ribeiro Rita Aparecida
Published: December 2020

A participação cidadã no espaço público urbano pode ser incentivada pela atividade do design, contrapondo-se à manipulação de forças dominantes que modelam a usabilidade das cidades e criam padrões segregativos. Designers, conscientes de sua responsabilidade social e através de uma visão humanista, modificam o arranjo espacial e o sentimento de pertencimento dos indivíduos, ou seja, objetos, mensagens, sistemas e experiências se configuram como potencializadores da dinâmica do cotidiano urbano e da afirmação do direito à cidade. O presente artigo explora o conceito experiência da alteridade como um caminho ou inspiração que intercede as práticas de design, sendo essas práticas exploradas neste trabalho pela atuação do Coletivo Micrópolis, em projeto de intervenção no bairro Calafate, Belo Horizonte, Brasil, na breve análise do impacto das instalações de varandas urbanas nas ruas e calçadas da cidade, no qual se descrevem atributos direcionados ao uso de mobiliário inclusivo e descrição de projeto de design, intitulado Borrachalioteca Sobre Rodas (BSR), divulgado e implementado para a comunidade de Sabará, Brasil. O intuito deste trabalho é incitar a reflexão dos atuais diálogos sobre a vivência e a humanização da cidade.
México, libros como signos de su historia cultural. Clasificar, reflexionar: letras para la infancia y religión
Authors: de Santiago Gómez Arnulfo Uriel
Published: December 2020

Siendo la literatura infantil y juvenil (LIJ) un fenómeno complejo, no abordo aquí el estudio de sus distintas formas ni el más general de la religión. Tampoco esbozo su historia, sino presento una lista de manifestaciones de una de sus múltiples caras: las letras religiosas dirigidas a la niñez y a la juventud como expresión de creencias o formas de culto propias de las poblaciones que han poblado el territorio que hoy ocupa México, diversas conforme a las épocas históricas aquí consideradas. Parto de considerar que la LIJ en general, y este rostro en particular, muestra la riqueza de nuestra herencia cultural. Así, las partes que integran este artículo van de nuestros pueblos originarios a la evangelización española; y luego en algunas de sus décadas desde el siglo XIX hasta el XXI. Alrededor de la LIJ puede continuarse el diálogo, el estudio de múltiples soportes: la oralidad en las voces que reproducen sus leyendas, cantos y oraciones; o sus textos mismos a través de los medios de comunicación o en impresos, para invitar a una reflexión en común acerca de nuestra historia cultural.
La necesidad de actualizar y modernizar la enseñanza de la Historia: hacia un sentido de vida y pertenencia en los niños
Authors: Sacal Halabe Linda
Published: December 2020

Las nuevas generaciones requieren y demandan nuevas maneras de aprendizaje. Es necesario replantear y actualizar los conocimientos que se les imparten. La enseñanza de la Historia en las aulas debe reformularse. Las nuevas tecnologías aplicadas a la teoría de Framing, a un proceso de extrañamiento, a recursos estéticos creativos y a la recepción literaria en su interacción con el medio exterior, a través de la narrativa histórica infantil son una alternativa para abrir un gran abanico de posibilidades y fomentar un espacio de reflexión, comprensión e identificación con el pasado.
Myocardial strain echocardiographic assessment: from theory to practice
Authors: Karev E. A. , Verbilo S. L. , Malev E. G. , Prokudina M. N. , Mochalov P. A. , Bobrova E. A. , Malinina N. P. , Kozlenok A. V.
Published: December 2020

Assessment of systolic and diastolic ventricular function is one of the main goals of echocardiography. Nevertheless, some patients require data beyond standard echocardiographic protocol for making more precise clinical decision and prognosis determination. The spectrum of novel parameters, including myocardial strain and strain rate, provides more comprehensive evaluation of the initial changes in myocardium in a variety of clinical conditions. New methods of quantifying the systolic function of left and right ventricles can be applied in patients with arterial hypertension, coronary heart disease, hypertrophic and dilated cardiomyopathies, also in patients with valvular heart disease such as aortic stenosis, aortic and mitral insufficiency. Besides strain analysis in patients with myocardial storage diseases, patients on cardiotoxic chemotherapy and patients with heart transplant turned out to be a specific niche for the method. Here, we provide the possibilities of strain analysis in variable heart pathologies in clinical practice.
Rodzaj gramatyczny w nauczaniu polszczyzny Ukraińców: perspektywa z „wewnątrz” oraz z „zewnątrz” systemu języka polskiego
Authors: Krawczuk Ałła
Published: December 2020

Artykuł przedstawia – na tle literatury przedmiotu – wybrane zagadnienia związane z nauczaniem kategorii polskiego rodzaju gramatycznego w środowisku ukraińskojęzycznym. Nowością w analizach jest chęć konsekwentnego dostrzegania dwu możliwości kwalifikacji i oceny niektórych błędów rodzaju: z „wewnętrznej” perspektywy systemu języka polskiego, ale też z perspektywy „zewnętrznej” – języka pierwszego osoby popełniającej błąd i pragmatycznego kontekstu wypowiedzi. Uwzględnienie stanowiska drugiego, częściowo psycholingwistycznego, daje możliwość rozważenia dopuszczenia: a) niektórych alternatywnych do istniejących rozwiązań w typologiach błędów w polszczyźnie Ukraińców i innych osób ze Wschodu, b) zróżnicowanej oceny błędów w zakresie rodzaju, popełnianych w zależności od wpływu czynników takich jak brak kompetencji oraz innych, psychofizycznych. Zwraca się też uwagę na potrzebę nauczania polonistów zagranicznych w sposób umożliwiający skuteczne zastosowanie przez nich teorii rodzaju w praktyce językowej oraz przyszłej działalności glottodydaktycznej.
Starzy piloci na moście, czyli dyskretny urok alternacji
Authors: Madelska Liliana
Published: December 2020

Język polski niesłusznie uchodzi za trudny, skomplikowane natomiast wydawać się mogą alternacje morfonologiczne, które występują w odmianie czasowników, rzeczowników, przymiotników, liczebników, zaimków i imiesłowów, w stopniowaniu, a także w słowotwórstwie. Artykuł pokazuje, iż do uporządkowania z pozoru chaotycznego świata polskich alternacji wystarczy kilka prostych reguł. Ucząc języka polskiego jako obcego, warto wprowadzać te reguły krok po kroku już na początkowym etapie nauki. Warto pamiętać, że odpowiednio zaprezentowane przykłady mówią czasem więcej niż długie komentarze metajęzykowe. Przy takim podejściu liczne formy gramatyczne nie jawią się jako ocean wyjątków, lecz jako sieci powiązań, które da się opanować.
Polish – just like “another english”: perceptions of translanguaging and other bilingual practices in English and Polish FL classrooms in Taiwanese universities
Authors: Tsai Natalia
Published: December 2020

The purpose of this paper is to analyse how English and Polish FL learners in Taiwan perceive translanguaging and other bilingual practices implemented in university classrooms. Around 70% of the questionnaire respondents were positive about monolingual instruction, however, only 7% though it should prevail. More than 90% accepted the usage of more than one language in class. Among the main benefits of single-language instruction, efficiency of the learning process and promoting one’s listening and speaking skills were mentioned. Deeper understanding and easier self-expression were seen as the main benefits of the bilingual approach. Different in-class activities that should be carried out in the target/native language have also been listed. Generally, the participants preferred mixed-language instruction, although they were aware of the benefits of the monolingual approach. Thus, teachers may consider including more diversified techniques to answer to the varying needs of Taiwanese EFL and PFL learners.
Spiritual well-being among cancer patients and their nurses
Authors: Akbari Masoumeh , Naderi Jaleh , Jelili Shayan
Published: December 2020

Experiences of people living with cancer have revealed that spiritual well-being is a vital aspect of a healthy life, necessary for creating a positive psychology and will guide patients toward a meaningful life. It can also increase cancer patients' adaptability and improve their quality of life and survival. The present study aimed at determining the spiritual well-being among cancer patients and their nurses. This descriptive-cross sectional study carried out with a convenience sampling method and participation of 120 hospitalized cancer patients and their nurses in oncology units. Data were collected using Paloutzian and Ellison well-being questionnaire (r = 0.82) and were analyzed using, chi-square and t-tests by using SPSS 21. The average scores of religious, existential and spiritual well-being in patients were 52, 46 and 99 respectively. Their average scores of religious, existential and spiritual well-being in nurses were 29, 40 and 70 respectively which falls within an average range (41-99). Comparing spiritual well-being scores between patients and nurses using chi-square and t- tests showed a significant difference (p=0.001). Spirituality and positive psychology have always been considered as effective treatment for people who are suffering from cancer. Increased spiritual well-being among nurses can improve spiritual health in cancer patients.          

 

Keywords: cancer patients, spiritual well-being, religious well-being, existential well-being, positive psychology, nurses.
SZÁMNEVET TARTALMAZÓ FRAZEOLÓGIAI EGYSÉGEK A SZERB ÉS A MAGYAR NYELVBEN
Authors: Andrić Edit , Zvekić Dušanović Dušanka
Published: December 2020

A tanulmányban olyan szerb frazeológia egységek kerülnek feldolgozásra, amelyeknek számnévi alaptagjuk van, azzal a céllal, hogy megkeressük magyar nyelvű ekvivalenseit, illetve hiányukban szó szerinti fordítást adunk. Ezen kívül a szólások néhány szemantikai jellemzőire is rámutatunk, amelyek alapján csoportokba soroljuk őket. Az elemzés alapján azt a következtetést lehet levonni, hogy léteznek szólások, amelyek formájuk és jelentésük tekintetében mindkét nyelvben megegyeznek, de vannak olyanok is, amelyeknél a lexikai szerkezet módosul, illetve olyan szerb frazémák is előfordulnak, amelyeknek nincs megfelelőjük a magyarban.
The Role of Wikipedia in providing information on coronavirus to Societies during the COVID-19 Pandemic
Authors: DOĞANER Adem
Published: December 2020

Objective: The coronavirus, which had first appeared in late 2019, turned into a pandemic spreading all over the world in a short time. People used internet resources to get information during the pandemic process. Wikipedia is one of the popular sources of internet preferred for accessing information in diseases and previous outbreaks. This study, the use of Wikipedia as an internet source in the coronavirus pandemic process was evaluated. The societies access to the articles on Wikipedia has been analyzed in detail.Methods: In the study, among the articles related to coronavirus on Wikipedia, the articles with a high number of views, which are displayed between January 20, 2020, and May 20, 2020, containing information in all languages were determined. 4 articles with the highest number of views matching these items were selected. These articles were evaluated in terms of views and updates. Searched topics on Wikipedia by societies during to pandemic process were determined.Results: The number of Wikipedia searches in search engines increased significantly in the period of 20 January 2020 - 20 May 2020 compared to the period of 20 January 2019 - 20 May 2019 (p<0.001). During the Coronavirus pandemic, "Wikipedia" was searched more in search engines. 4 articles reached over 130 million page views in total. Societies have researched past outbreaks and measures against coronavirus on Wikipedia.Conclusion: Wikipedia has been an important source of internet for societies during the coronavirus pandemic process. Wikipedia data can be applied to predicting and modeling trends in societies.
A rare Localization of Mixoma: Originating in the Right Atrial Septum
Authors: DERELİ Seçkin , ÜRKMEZ Melih , TAYFUR Kaptaniderya , YENERÇAĞ Mustafa , KAYA Ahmet , FİLİZ Mehmet
Published: December 2020

Myxoma is the most common bening cardiac tumourt. Approximately 75-80 % of cardiac myxomas are located in the left atrium. The most common non-specific symptoms are such as shortness of breath, syncope. A 74-year-old female patient was admitted to our outpatient clinic with shortness of breath and chest pain, in the echocardiography showed a mobile mass in the right atrium. The patient, whose diagnosis of myxoma was confirmed by trans esophageal echocardiography, underwent intracardiac mass excision. Because the right atrial myxomas are rare, we wanted to present our patient. An underlying cardiac pathology should be kept in mind in patients presenting with symptoms such as non-specific breathlessness
Comparison of Videofluoroscopic Swallowing Study and Fiberoptic-Endoscopic Evaluation of Swallowing Findings in Pediatric Patients
Authors: GÜNGÖR Volkan , AKYOL Mehmet Umut , DEMIR Numan , SEREL ARSLAN Selen , SÜSLÜ Nilda
Published: December 2020

Objective: This study is designed to determine the value and accuracy of Fiberoptic Endoscopic Evaluation of Swallowing (FEES) in the diagnosis of swallowing disorders as a diagnostic tool, in comparison with the widely accepted Videofluoroscopic Swallowing Study (VFSS) in pediatric patients.Methods: Cross-sectional study in tertiary referral center. Fifty one children with swallowing difficulty due to various diseases were prospectively evaluated using both VFSS and FEES. The variables, early pharyngeal spillover, pharyngeal residues, laryngeal sensitivity-silent aspiration, laryngeal penetration and laryngeal aspiration were evaluated in all patients. Results: Mean patient age was 29.8±17.8 (range 9-72) months. Six patients were younger than 13 months, 19 were between 13 and 24 months, and 26 patients were older than 2 years of age. There were 21 (42%) females and 30 (58%) males in the study group. Significant correlation in pharyngeal residues and laryngeal sensitivity-silent aspiration findings were found between FEES and VFSS data. No Significant dissimilarity in laryngeal aspiration and penetration evaluation was found. Conclusion: Swallowing evaluation in children is more challenging than adults. Study findings showed that FEES outcomes correlate with VFSS data, especially in the diagnosis of laryngeal aspiration and FESS is a valuable tool in identifying swallowing disorders in pediatric patients
Microorganisms that Reproduce in Wound Cultures in Rize Region and Their Antimicrobial Susceptibility
Authors: BAHÇECİ İlkay
Published: December 2020

Objective: Among nosocomial infections, wound infections are one of the important factors causing mortality and morbidity after urinary tract infections. In this study, it was aimed to guide the empirical treatment and to contribute to epidemiological data by determining the microorganism and antimicrobial susceptibility which have been isolated from cultures of wounds and abscesses, which came from outpatient clinics, services and intensive care units, that grow in wound site and abscess cultures that comes from outpatient clinics, services and intensive care units.Methods: This study was conducted on the basis of cultures in which at least one microorganism grew in the wound site and abscess samples from the polyclinic, service and intensive care units during routine application at the Recep Tayyip Erdoğan University Training and Research Hospital Microbiology Laboratory, between January 2011 and December 2016. Samples were taken with two sterile swabs in the form of superficial swabs or deep aspiration and delivered to the laboratory with transport medium as soon as possible. Gram staining preparation was prepared and inoculated on 5% sheep blood agar, eosin-methylene-blue agar, chocolate agar and sabouraud dextrose agar. The gram-stained preparation was evaluated by Q scoring. Evaluation of the culture and antibiogram susceptibility were made according to the Clinical and Laboratory Standards Institute (CLSI) criteria.Results: A total of 2202 samples were received, and reproduction was observed in 930 samples. Among the 793 wound and 137 abscess samples, the most common microorganism was Staphylococcus aureus (224 cultures) and the second was Escherichia coli (135 cultures).Conclusion: Surgery clinics, especially orthopedics, provided the most common wound infections, from which S. aureus was the most isolated microorganism. The fact that bacterial, most notably S. aureus, propagation occurred from surgery samples indicates that surgical site infections are generally caused by endogenous flora. It has, thus, become apparent in our study that patients and hospital staff should pay more attention to hygiene, especially hand washing. Due to the changing of the distribution and resistance patterns of microorganisms that are frequently seen in hospitals at certain time intervals, their antibiotic susceptibility will be a guide in the rational use of antibiotics. Thus, specific treatment will contribute to the saving on the cost and reduce mortality.
THE CONSENSUS PREDICTION IN SILICO OF PHARMACOKINETIC PREFERENCE OF MULTI-TARGET RAGE INHIBITORS
Authors: Vasiliev P. M , Spasov A. A , Kochetkov A. N , Perfiliev M. A , Koroleva A. R , Golubeva A. V. , Martynova D. O , Babkov D. A , Litvinov R. A
Published: December 2020

Using a neural network model based on docking, among 87 new synthesized substances of ten structurally diverse chemical classes, ten compounds with predicted high RAGE-inhibitory activity were found, and for these by means of QikProp, PASS programs and on-line resources admetSAR, pkCSM, SwissADME and ADMET-PreServ a consensus in silico estimation of 14 pharmacokinetic ADMET characteristics was carried out. Based on these indicators, consensus integral estimates of pharmacokinetic preferences of these compounds were calculated and substances with favorable pharmacokinetic properties were identified.
COMPLICATION OF THE PRIMARY ANTITUBERCULAR VACCINATION
Authors: Dzheliev I. Sh , Lolaeva B. M
Published: December 2020

The aim of the study was to determine the causes and frequency of complications of TB vaccination in newborns, tactics of their treatment and prevention measures. The subject of the study were patients with chronic complications of tuberculosis vaccination: regional lymphadenitis, superficial ulcer, cold abscess, keloid scar, osteo-myelitis. Analysis of morbidity carried out in the Republic of North Ossetia - Alania from 2010 to 2018. A direct correlation of complications with the level of brevemente children with tuberculosis, a decrease in reactivity and change them-munna status of mother and newborn, violation of technology of introduction of the BCG vaccine. The tactics of treatment of each type of complications is defined.
ACUPUNCTURE IN TREATMENT OF РАTIENTS WITH CRONIC DERMATOSES
Authors: Klinova N. G , Ivanova I. N , Popov V. V. , Rusinov V. I
Published: December 2020

The article is devoted to reflexotherapy of patients with different dermatoses. The experience of treatment with acupuncture of chronic skin diseases in reflexotherapy room is analised. The selection of acupuncture meridians and points in dermatological patients is proposed. The results of acupuncture of patients with lichen ruber planus, atopic dermatitis, eczema, chronic urticaria, prurigo, psoriasis of palms and soles, lichen ruber pillaris Devergy are discussed. Effect of therapy on basis of psychosomatic nature is explained.
COMPARATIVE EVALUATION OF AUTONOMIC REACTIVITY IN PATIENTS WITH CHRONIC HEART FAILURE AND TYPE 2 DIABETES MELLITUS WITH DIABETIC AUTONOMIC CARDIAC NEUROPATHY
Authors: Krayushkin S. I , Shalaeva S. S , Ivakhnenko I. V , Sadykova E. V.
Published: December 2020

The dependence of heart rate variability in patients with chronic heart failure (CHF) and type 2 diabetes on the severity of diabetic autonomic cardiac neuropathy (DACN) is described. 60 patients with Functional Class II-III CHF and type 2 diabetes, 30 of them had signs of DACN of varying severity were examined. The temporary values of heart rate variability, spectral characteristics were estimated, as well as the ratio of sympathetic and parasympathetic influences. It was revealed that patients with CHF and type 2 diabetes complicated by DACN had significant disturbance of autonomic regulation and the prevalence of adverse types of autonomic reactivity. At the same time, the severity of autonomic disorders increased with the aggravation of autonomic dysfunction.
THE RESULTS OF THE ENDOVASCULAR PROSTHESIS IN PATIENTS WITH INFRARENAL AORTIC ANEURYSMS
Authors: Mozgovoy P. V , Lukovskova A. A , Spiridonov E. G , Zharkin F. N , Ufimtsev V. S , Moiseev D. V
Published: December 2020

An early and late results of endovascular prosthetic repair of the aorta were described. For 9 years, 71 patients with infra-renal aortic aneurysms underwent endovascular aortic prosthetics. In the early postoperative period, type II endoleaks were registered in 4,2 % of cases, and endoprosthesis branch thrombosis in 1,4 %. Systemic complications accounted for 2,8 %, with no hospital fatality. In the long-term period, the primary patency of shunts was 91,18 %. Endovascular aortic prosthetics is a safe and effective method of treating infra-renal aortic aneurysms, which demonstrates a low level of complications and mortality in the early postoperative period.
EFFECT OF THERAPY WITH A FIXED COMBINATION OF PERINDOPRIL AND AMLODIPINE ON VASCULAR AGE AND 5-YEAR RISK OF CARDIOVASCULAR COMPLICATIONS IN PATIENTS WITH ARTERIAL HYPERTENSION AND MILLITUS DIABETES TYPE 2
Authors: Statsenko M. E , Turkina S. V. , Skibitsky V. V. , Derevyanchenko M. V. , Titarenko M. N
Published: December 2020

In recent years, the concept of cardiovascular risk factors, one of which is the process of vascular aging, has been of great interest. 30 patients with stage 2-3 of arterial hypertension and type 2 diabetes mellitus aged 45 to 65 years were included, including 23 women and 7 men. Patients after the washout period a fixed combination of perindopril with amlodipine (the original drug Prestans, AO Servier) in the form of tablets (perindopril arginine / amlodipine bezilat) were prescribed for 12 weeks, 1 time per day. Vascular age and 5-year risk of developing cardiovascular complications were calculated on the calculator app for smartphones ADVANTAGE AGE (Les laboratories Servier version 2, 2015). After 12-week therapy with a fixed combination of perindopril and amlodipine, the achievement of target blood pressure values was noted in 100 % of patients. The average passport age of the patients included in the study was (61,9 ± 4,4) [45; 65] years. In assessment vascular age, there was a statistically significant initial increase in vascular age above the passport age - (69,3 ± 8,5) [55; 89] years. 46,7 % of patients have an average risk of developing cardiovascular complications and 53,3 % of patients have a high risk of cardiovascular accidents. After 12 weeks of therapy with arginine perindopril and amlodipine bezilate, there was a significant decrease of vascular age to 63,1 ± 5,6 [51; 73] years, a decrease in the percentage of patients with high risk of cardiovascular complications to 23,4 % (p < 0,05), due to patients with average risk (53,3 %, at p < 0,05), and the appearance of patients (3,3 %) with a low risk of cardiovascular accidents within 5 years. In patients with arterial hypertension and diabetes millitus type 2, vascular age significantly increases in comparison with the passport age. The use of a fixed combination of perindopril arginine / amlodipine bezilate for 12 weeks in this category of patients significantly reduces the vascular age of patients and reduces the frequency of detection of patients with high and medium risk of cardiovascular accidents.
COMPARATIVE RESULTS OF ARTHROSCOPIC ANATOMICAL ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION USING PATELLAR TENDON AND HAMSTRINGS AUTOGRAFTS
Authors: Suchilin I. A , Malanin D. A , Volodin I. V. , Julikov A. L
Published: December 2020

Complete traumatic injuries of the anterior cruciate ligament (ACL) are the most common knee injury among physically active males and females who are fond of both traditional and extreme sports. Surgical restoration of the anatomical structures of the injured joint, even with isolated ACL damage, remains an urgent problem of modern traumatology and orthopedics. The technology of arthroscopic reconstruction of the ACL is developing along the path of improving the technique of surgery, fixators, plastic materials. The article is devoted to the study of the results of arthroscopic anatomical plastic surgery of the anterior cruciate ligament with autografts from the patellar ligament with two bone blocks and the hamstring flexor tendons. The study included 100 patients of the main group and the comparison group with chronic damage to the anterior cruciate ligament and chronic anterior instability of the knee joint, which were divided into two groups depending on the type of transplant used. Long-standing injuries of the anterior cruciate ligament were diagnosed based on the results of a clinical examination, radiography, magnetic resonance imaging, and hardware arthrometry. Excellent and good results of surgical treatment were obtained in most patients of both groups, however, the highest stabilization indicators of the knee joint were noted in the comparison group.
MODERN TERMINOLOGY, PATHOGENESIS, DIAGNOSTICS AND TREATMENT OF CHRONIC ABDOMINAL SYNDROME IN CHILDREN
Authors: Khvorostov I. N , Sinizyn A. G , Kopan G. A , Damirov O. N , Andreev D. A , Verbin O. I , Shramko V. N
Published: December 2020

The terminology of chronic abdominal pain, as well as further treatment tactics, are still the subject of debate. Conservative treatment in some patients with chronic abdominal pain is ineffective. Laparoscopic appendectomy is a scientifically based surgical intervention for patients with chronic abdominal syndrome with localization in the right iliac region in children who do not show peritoneal signs and changes in laboratory parameters, with the exception of intercurrent pathology by non-invasive methods.
ANALYSIS OF INDICATIONS AND RESULTS OF SURGICAL TREATMENT OF ANKYLOGLOSSIA IN CHILDREN
Authors: Fomenko I. V , Kroman Yu. O , Kasatkina A. L , Timakov I. E , Fursik D. I
Published: December 2020

The article is devoted to the analysis of the indications and results of surgical treatment of ankyloglossia in children. Patients were divided into three age groups I - 3-6 years old, II - 7-9 years old, III - 10-12 years old. The result of treatment was rated as very good, good, satisfactory, unsatisfactory. It was found that the most frequent indication (86,4 %) for surgery in children was a problem of speech. A very good treatment result was most often found in the first group (76,6 %). 74,4 % of operated children who had undergone tongue training exercise and speech therapy had normalization of sound pronunciation.
RISK OF BRONCHIAL ASTHMA DEVELOPMENT IN CHILDREN WITH BRONCH-OBSTRUCTIVE SYNDROME AND AN INITIALLY LOW ASTHMA PREDICTIVE INDEX
Authors: Dzhumagaziev A. A , Savenkova N. D , Bezrukova D. A , Bogdan'yants M. V.
Published: December 2020

With the using a binary logistic regression analysis, a representative model it was constructed that allows in 80,7 % of cases to predict the risk of developing bronchial asthma in children of early and preschool age with recurrent wheezing and an initially low Asthma Predictive Index (API) in school age with a high discriminatory ability (AUC = 0,901).
EMERGENCY PSYCHOLOGICAL AID IN THE VOLGOGRAD REGION
Authors: Shkarin V. V , Rayevsky A. A , Volchansky M. E , Delaryu V. V. , Boluchevskaya V. V.
Published: December 2020

Analysis of 830 cases of psychological assistance to victims of emergency situations from 2013 to 2018 in the Volgograd region showed the effectiveness of its organization and activities.
INFLUENCE OF PEPTIDE IMITATING A-SPIRAL OF B ERYTHROPOETHIN ON THE DEVELOPMENT OF MORPHOFUNCTIONAL DISORDERS IN EXPERIMENTAL PRECLAMPPS
Authors: Golubev I. V. , Zatolokina M. A , Gureev V. V. , Polyanskaya A. V. , Gureeva A. V. , Avdeyeva E. V. , Zatolokina E. S.
Published: December 2020

Preeclampsia remains a formidable disease in the second half of pregnancy. Therefore, the search for new drugs for the treatment and prevention of preeclampsia is an urgent task of modern pharmacology. Materials and methods. The experiment was performed on female Wistar rats. The studied drugs were administered from 10 to 21 days of pregnancy. Functional tests were performed on the 21st day of pregnancy. Results. The use of a peptide that imitates erythropoietin а-helix B in experimental preeclampsia leads to a pronounced correction of pathological changes: blood pressure decreased, microcirculation in the placenta increased, and the morphological picture in the placenta improved. Resume. The results indicate the promise of the use of a peptide imitating а-helix B erythropoietin in experimental preeclampsia.
A MODIFIED METHOD FOR STUDYING THE GLYCOXIDATION REACTION
Authors: Litvinov R. A , Kosolapov V. A , Muravyova E. A , Skachko I. V. , Shamshina D. D
Published: December 2020

The article considers a particular model of the glycation reaction, called glycoxidation and characterized by a significant involvement of oxidative reactions and the participation of transition metals. The enhancement of oxidative processes, which makes it possible to identify the reaction as glyoxidation, was realized by introducing copper (II) cations (CuSO4 * 5H2O) into the reaction medium in a form accessible for interaction with the reaction participants. The main reagents in the glycoxidation reaction, in addition to CuSO4*5H2O are bovine serum albumin (1 g/l), glucose (0,5 M), HEPES buffer solution (24 g/l) dissolved in deionized water. The conditions have been selected under which the glycoxidation reaction linearly depends on the concentration of copper (II), which makes the cation activity a sensitive target when monitoring the reaction. The dependence of the reaction on the concentration of CuSO4 * 5H2O under the presented experimental conditions has been confirmed experimentally and mathematically. An analytical range of concentrations of CuSO4*5H2O has been established, in which a linear dependence of AGE formation on concentration is observed. For the concentration of CuSO4*5H2O, which produces the greatest potentiating effect on the AGE formation (10 mg/l), the procedure was validated by the indices of internal laboratory reproducibility and convergence. The technique is of interest for investigation of the antiglycoxidative activity of novel compounds
CLINICAL AND LABORATORY ANALYSIS OF THE EFFECTIVENESS OF TREATMENT OF DEEP CARIES WITH CALCIUM-CONTAINING PADS
Authors: Makedonova Yu. A , Poroisky S. V. , Gavrikova L. M , Venskel E. V.
Published: December 2020

The task of a dentist in the treatment of deep caries (pulp hyperemia) is not only to restore the integrity of the tooth, but also to stimulate the production of replacement dentin with the help of a medical pad, to ensure reliable isolation of the pulp from the toxic effects of materials. Having a wide range of different therapeutic pads, but not having methods to objectively assess the condition of the pulp, doctors have to «blindly» give preference to a particular manufacturer. In this work, based on a clinical and laboratory study, an analysis of the effectiveness of calcium-containing pads «Life» and «Dycal» - was performed. The clinical stage was performed on patients in the treatment of deep caries. Changes in the pulp microcirculation were evaluated using laser Doppler flowmetry. During histological examination, samples of tooth cuts were studied for analysis of micro-flows of the dye at the «seal-tooth» border and the depth of penetration of the dye. The clinical results are consistent with laboratory results, which can be used to draw conclusions about the benefits of the «Life» treatment pad in the treatment of deep caries.
IMPACT OF SOME FACTORS ON QUALITY OF LIFE OF ELDERLY CASES WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Authors: Turkina S. V , Grishchenko A. A , Zhernakova N. I , Lebedev T. Yu.
Published: December 2020

40 elderly and senile patients were examined including 20 patients with exacerbation of chronic obstructive pulmonary disease (COPD) of moderate severity (experimental group) and 20 cases without COPD, acute diseases and exacerbations of chronic pathology (control group). Impact of COPD was studied for various aspects of quality of life. It was analyzed the nature and strength of the relationship between of quality of life indicators and biochemical survey results.
COMPARATIVE ASSESSMENT OF SPINCTER MUSCLE COMPLEX IN CHILDREN AFTER SURGICALCORRECTION OF ANORECTAL MALFORMATION
Authors: Khvorostov I. N , Shramko V. N , Andreev D. A , Verbin O. I
Published: December 2020

A comprehensive study of the state of the spincter muscle complex in children after surgical correction of anorectal malformations was carried out,including MRI of the structure of the spincter muscle complex,fecal continence on the Rintala scale, manometric studies of the anal function.The poor development of the spincter muscle complexwas characterized by a decrease (p < 0,05) of the average values of the relative width of the puborectal muscle (PRWR) to 0,14 ± 0,03, for the relative width of the external anal sphincter (EASWR) to 0,12 ± 0,02, which turned out to be 2,4 times lower than patients with excellent and good results. Values of PRWR 0,15.
THE INFLUENCE OF THE AGONIST OF RECEPTORS GPR-119 (COMPOUNDS ZB-16) ON SPERMATOGENESIS AND FERTILIZATION FUNCTION OF MALE RATS
Authors: Bugaeva L. I , Kuzubova E. A , Maltsev M. V. , Lavrova E. B , Tyurenkov I. N , Kurkin D. V , Volotova E. V. , Bakulin D. A , Dudchenko G. P
Published: December 2020

In experiments on outbred male beauty 4 months of age, the effect of the new compound ZB-16 (GPR 119 receptor agonist), with hypoglycemic activity [6], on spermatogenesis and fertilizing function was studied. Compound ZB-16 was administered intragastrically to animals of the experimental groups for 2 months (equivalent to one spermatogenesis cycle) in doses: 0,5 mg/kg (experimental therapeutic dose) and 100 mg/kg (higher dose than 200 times the therapeutic dose), the control group of males was intragastrically injected with a solvent of the compound - distilled water. It was found that under the influence of ZB-16, in males in both experimental groups, the spermatogenesis index is moderately increased (by 3,0 %, p > 0,05), the total number of spermatozoa (by 44,4 %, p > 0,05 and 19,2 %, p > 0,05, respectively, the 1st and 2nd experimental groups), the number of tubules with desquamated epithelium decreases, and the number of pathological forms of spermatozoa and the number of tubules with 12th stage of meiosis are not changed. According to the results of mating of the studied groups of males with intact females, a clear tendency towards an increase in the pregnancy index and a decrease in the post-implantation death of the embryos is revealed in the females relative to the control.
STUDY OF HESPERIDINE AND CURKUMIN NOOTROPIC ACTIVITY UNDER THE CONDITIONS OF FOCAL CEREBRAL ISCHEMIA
Authors: Voronkov A. V , Nigaryan S. A , Pozdnyakov D. I
Published: December 2020

The article presents the results of the study of the nootropic activity of hesperidin and curcumin in conditions of focal cerebral ischemia. Studies were conducted on Wistar male rats, which reproduced the focal ischemia of the right middle cerebral artery. Experimental compounds and the reference drug (Mexidol) are administered intragastrally at the next day after surgery at a dosage of 100 mg/kg for three days. Researched using memory and cognitive assessment models -the method of avoiding passive (passive avoidance reaction) and active (TEA) environments. The effect of these compounds on the level of formation of lactate, pyruvate, and the degree of necrosis was studied. Against the background of focal cerebral ischemia, hesperidin significantly improved the studied parameters, curcumin did not show a positive effect on all the studied parameters, and therefore inferior to the heotropic activity on nootropic activity. The results of experimental data suggest the possibility of further in-depth study of hesperidin for cerebroprotective and nootropic activity.
ASSESSMENT OF ANATOMICAL CONDITIONS FOR THE INSTALLATION OF MINISCREWS «BIORAY A1» IN THE AREA OF THE MANDIBULAR BUCCAL SHELF
Authors: Klimova N. N , Markova A. V. , Klimova T. N
Published: December 2020

Currently, miniscrews installed parallel to the roots are widely used in the practice of orthodontic treatment. When planning the placement of miniimplants, it is necessary to evaluate the anatomical factors that affect the stability of the miniscrew in the bone. For the analysis, we selected the zone of the external oblique line, where the thickness of bone tissue in the area of the first and second molars was estimated in the vertical and horizontal planes. As a result of the study, it was found that the area of the distal surface of the distal root of the second molar had the greatest thickness of bone tissue. An increase in the vestibular-oral thickness was also observed in the distal direction.
FORENSIC ASPECTS OF NON-MEDICAL CONSUMPTION OF PHENOBARBITAL IN THE TERRITORY OF VOLGOGRAD
Authors: Barkanov V. B , Prokofiev I. I , Ermilov V. V , Lobyntseva E. N , Vlasova E. V , Zagrebin V. L , Sivik V. V.
Published: December 2020

The analysis of the structure of mortality from the toxic effect of phenobarbital in the city of Volgograd for the period 2014-2018 was carried out. It was revealed that the mortality rate as a result of taking phenobarbital for the indicated period more than doubled, especially among the working age population (35-50 years). When comparing this indicator with a similar one for the period 1994-1998 an increase in the number of lethal poisoning with phenobarbital by 26 % was noted. It was found that taking phenobarbital is often combined with other toxic substances (ethyl alcohol - in 36 % of cases, opiates and opioids - in 11 %, benzodiazepines - in 7 %, antidepressants and neuroleptics - in 6 %, etc.) In most cases, with phenobarbital poisoning, the presence of pathological signs of secondary cardiomyopathy, chronic ischemic heart disease, ventricular fibrillation, acute alveolar emphysema, edema of the substance and membranes of the brain, toxic encephalopathy, necronephrosis was revealed. The results obtained can be considered as additional data when conducting forensic medical diagnostics of acute phenobarbital poisoning and will be useful already at the stage of studying the primary documentation, as well as during the forensic medical examination of the corpse.
PARADOXAL ACTIVITY OF AMINOGUANIDINE IN THE MODEL OF GLYCOXIDATION WITH COPPER CATIONS
Authors: Litvinov R. A , Usmiyanova L. E , Klimenko D. R , Gontareva A. V.
Published: December 2020

The well-known inhibitor of advanced glycation-end products (AGEs) formation aminoguanidine, was studied using a previously tuned model of glycoxidation in copper-contained media (glucose 0,5 M, HEPES 0,1 M, CuSO4x5H2O 40 μM). As a result of the research, it was confirmed that aminoguanidine (1, 3, 10 mM) under conditions of glyoxidation with copper does not suppress the formation of argpyrimidine by detection of argpirimidine's self-fluorescence (Aex 330 nm, Aem 360-450 nm). Possible reasons of the enormous reaction are discussed.
ASSESSMENT OF THE DENTAL STATUS OF PREGNANT WOMEN
Authors: Miklyaev S. V. , Miklyaeva I. A
Published: December 2020

A survey of 86 pregnant women was conducted in order to study the hygienic state of the oral cavity at different stages of pregnancy. It was found that 62 (72,09 %) of pregnant women were motivated to visit the dental office to maintain their own health and the health of the unborn baby, 20 women (23,25 %) were concerned about the safety of their own dental system, 4 women (4,65 %) did not understand the need to visit a dentist. The dental status of pregnant women was assessed based on dental indices: OHI-S, CPITN, PMA, and the H. R. Muhleman gum bleeding index. The dependence of the level of oral hygiene on the duration of pregnancy was revealed, at the same time, the severity of the inflammatory process did not depend on the trimester.
ANALYSIS OF CLINICAL CASES OF VENOUS THROMBOEMBOLIC COMPLICATIONS DURING PREGNANCY, CHILDBIRTH AND EARLY POSTPARTUM PERIOD
Authors: Poliantsev A. A , Frolov D. V. , Andreeva M. D , Linchenko D. V. , Dyachkova Yu. A , Nalesnyi A. E , Yakovleva D. A
Published: December 2020

Aim: based on clinical cases, to show an insufficient amount of measures for the prevention of venous thromboembolic complications during pregnancy, childbirth and the early postpartum period when women are managed in accordance with national guidelines. Materials and methods: the retrospective study included 25 women aged (28,1 ± 6,3) years, hospitalized during pregnancy and early postpartum period in the department of vascular surgery due to venous thrombosis of the inferior vena cava system. All patients underwent ultrasound duplex scanning of blood vessels to verify the diagnosis. The therapeutic approach to patients is considered from the standpoint of domestic and international recommendations. Results: thrombosis was most often complicated by the third trimester of pregnancy and the early postpartum period - 56 % of all cases. In the majority of patients, thrombosis was widespread and proximal: in 72 % of women, the upper border of the thrombus was localized at the level of the iliac veins. When scoring the risk of developing venous thromboembolic complications according to the 2015 Royal College of Obstetricians and Gynecologists scale in the patients participating in the study, it turned out that most of them were shown drug prevention. Conclusions: it is necessary to use national and international recommendations to prevent thrombotic complications in pregnant women and postpartum women.
MODERN METHODS OF BREAST RECONSTRUCTION. OWN EXPERIENCE
Authors: Telichko S. V. , Kovalenko N. V. , Zhavoronkova V. V. , Ivanov A. I , Sukhov V. A , Speransky D. L , Devyatchenko T. F , Chuhnin A. G
Published: December 2020

The role and methods of reconstructive and plastic surgery in the treatment of patients with breast cancer are considered. Presented our own results of treatment patients taking into account the main requirements of the treatment: oncological safety and improving the quality of life when using reconstructive plastic surgery.
FEATURES OF SURGICAL APPROACHES TO THE DIAGNOSIS AND TREATMENT OF THYROID DISEASES IN PATIENTS OF OLDER AGE GROUPS
Authors: Kukhtenko Yu. V. , Ryaskov L. A , Kosivtcov O. A , Mikhin I. V. , Abramian E. I , Kitaeva A. V.
Published: December 2020

Diagnostics, tactics of medical and surgical treatment of various diseases of the thyroid gland is a topical issue in patients of older age groups. The peculiarity of this category of patients is high comorbidity, so the volume of surgery should be determined not only by the type and severity of the course of thyroid pathology, but also by the clinical characteristics of concomitant diseases. To date, the issue of choosing the volume of surgery in elderly and senile patients remains debatable.