bluuebunny/crossref_metadata_2025 huggingface dataset:
Novel Silver Amoxicillin Nano-Structure Preparation by Gamma Irradiation with Outstanding Bactericidal Activity against Multidrug Resistant Enterobacteriacea Isolates
Authors: El-Batal Ahmed Ibrahim , Menofy Nagwan Gammal. El , Abdel-Wahab Fatema Bahaa El-Din , Mosallam Farag Marzouk , Abdulall Abeer Khairy
Published: March 2022

Infections caused by multidrug-resistant (MDR) Enterobacteriacea bacteria have been reported as one of the most rising problem worldwide that require exploration for new antimicrobials. Amoxicillin Nano-structure (Ag-Amox-Ns) with an antibiotic can synergistically inhibit the drug-resistant bacteria. The aim of the current study was to determine the antimicrobial activity of novel synthesized Silver Amoxicillin Nano-structure (Ag-Amox-Ns) using Gamma-irradiation against MDR Enterobacteriaceae clinical isolates. Aqueous dispersed Silver Amoxicillin Nano-structure (Ag-Amox-Ns) were synthesized using silver ion (Ag+ 2) as precursor, amoxicillin (Amox.) as stabilizing agent and gamma irradiation as reducing agent. The synthesized Ag-Amox-Ns are characterized by UV–visible spectroscopy, Dynamic light scattering (DLS), X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FT-IR). The morphology and the particles size and shape of Ag-Amox-Ns were estimated by TEM images, the mean size of Ag-Amox-Ns (45nm), XRD analysis of the Ag-Amox-Ns confirmed the formation of metallic nanoparticles. The nucleation and growth mechanism of Ag-Amox-Ns is also discussed. The size of nanoparticles is influenced by certain parameters such as the choice of stabilizer and silver ion concentration and absorbed dose. Antimicrobial activity of novel synthesized Ag-Amox-Ns against MDR Enterobacteriaceae clinical isolates was detrmined by standard microbiological assays. The MDR isolates include Klebsiella spp. (37.1%), Escherichia coli (35.2%) and Proteus spp. (27.7%). The fold increase % of Ag-Amox-Ns by disk diffusion assay was ranged from 66.6 to 316.6 for all tested isolates, furthermore novel conjugate decreased MICs for all strains. The MIC of amoxicillin decreased from more than 250 µg/ml to reach 7.812 µg/ml for 35% of MDR Klebsiella spp. and 47% of MDR E. coli isolates while it reached 3.906 for 40% of MDR Proteus spp. Ag-Amox-Ns is novel compound give promising inhibitory effect against MDR Enterobacteriaceae providing additional treatment options, and enables the use of inexpensive and unused antibiotics in combating bacterial resistance problem.
CFD Analysis for wind flow characteristics of varying cross section tall building using ANSYS
Authors: Raj Ritu , Rukhaiyar Ark , Jayant Bhagya , Dahiya Kunal
Published: March 2022

Tall buildings are being developed at rapid rates owing to the need for optimization of space for increasing urban crawl. Tall buildings having simple cross – sections are designed using IS 875 (Part 3) – 2015, however there is a lack of set of codal provisions for complex cross – section shapes. This study has been undertaken to interpret the wind flow characteristics of an isolated tall building (Model A) utilizing CFD (Computational Fluid Dynamics) and k - ɛ turbulence model in ANSYS: CFX (Analysis of Computational Fluid Dynamics program). Model A is 192 m in height having two types of cross sections – plus and square; each of height 96 m. Wind of intensity 10 m/s is incident on it at four incidence wind angles 0°, 30°, 60° and 90°. Pressure contours obtained on simulation indicate that for incident wind angles 0° and 90°, all lateral faces of the Model A (proposed design model) show similar pressure impact. Whereas, for incident wind angles 30° and 60°, wind ward faces (A and C) show decreased pressure impact with respect to 0° case. Vertical streamlines depict a recirculation zone at one – third the height of Model A for incident wind angle, 30°. Whereas, horizontal streamlines indicate the occurrence of vortex formation in the wake region of the building for incident wind angles, 0° and 90°.
Eating-related problems as effect of social media usage and the association with resilience and parental relationship
Authors: Carriker Nicholas , Hongsanguansri Sirichai , Pavasuthipaisit Chosita , Kiatrungrit Komsan
Published: March 2022

Background: Studies have found negative effects of social media on mental health. Others have studied the effects on eating-related problems. A few studies investigated the association between resilience and adolescent-parent relationship and these negative effects. So, the objective of this study is to study the association between the negative effects of body image focused social media use, and weight, body image and eating behaviors, and their association with resilience and adolescent-parent relationship. Methods: Cross-sectional descriptive research was conducted with a sample of 495 students from three schools in Bangkok. Students answered an online questionnaire comprised of age, sex, height/weight, body image focused social media usage, Body-esteem Scale for Adolescents and Adults, Eating Attitudes Test, Inventory of Parent and Peer Attachment for Children, and the Thai Resilience Quotient.Results: Mean (SD) age was 17.06 (0.805), with 307 female participants (62%). Time spent on social media was found to be associated with increased risk of being overweight and binging. Body image focused social media usage (BSMU) was associated with increased risk of inappropriate eating attitudes/behaviors. Higher resilience and adolescent-parent relationship were found to act as protective factors against binging and being in the overweight group.Conclusion: Body image focused social media usage was associated with inappropriate eating attitudes and behavior. Findings also suggest that higher resilience and adolescent-parent relationship can lower the risk of eating related problems. The effectiveness of resilience and parent-child relationship improvement programs should be explored to help protect against eating problems.
Prognostic value of CYBB as potential biomarkers for lung adenocarcinoma by TCGA and clinical validation
Authors: Liu Yingjie , Han Di , Zheng Yuan hang , lin Yi , Yang Chunqing , Yang Lun
Published: March 2022

Lung adenocarcinoma (LUAD) causes high morbidity and mortality; therefore, early diagnosis is essential. In recent years, rapid increases in high-throughput sequencing technologies’ efficiency and the continuous improvement of comprehensive online databases have facilitated the study of the genomic changes that affect tumor progression and the identification of tumor biomarkers; Therefore, we hope to find out the genes that may affect the progression and prognosis of LUAD. In this study, we used CIBERSORT and Estimate computing methods to analyzed data from The Cancer Genome Atlas, including the analysis of the proportion of tumor-infiltrating immune cells (TIC) in the tumor microenvironment (TME), cox regression analysis of differentially expressed genes, and cross analysis of protein interaction networks (PPI). We found that Cytochrome b-245 beta chain (CYBB), an indispensable gene in the immune system, also plays a vital role in lung cancer pathogenesis. Meanwhile, Western blotting, qRT-PCR and IHC were used to verify the down-regulation of CYBB expression in LUAD patients. Reduced CYBB expression occurs in patients with lung cancer, indicating that it may be a valuable biomarker and facilitate early diagnosis.
An Evaluation of Vegetation Loss Due to Super Typhoon Sarika in Hainan Island of China
Authors: Xiao Fengjin , Qiufeng Liu
Published: March 2022

With the aggravation of global climate change, various extreme climate events have become increasingly prominent. Super typhoon is the most disastrous event that causes severe loss to the economy, agriculture, transportation, communication, and ecosystem in coastal regions. Super typhoon severely impacts ecosystem structure and function and even leads to ecosystem degradation. In the current study, we assessed the impact of a super typhoon Sarika on vegetation in the tropical landscape of Hainan Island. The super typhoon Sarika that hit Hainan Island on 18 October 2016 lasted for 15 h and was the most severe typhoon affecting Hainan Island in October since 1970. The coastal land around Hainan Island generally faced gales with a wind speed of 35 m/s (maximum wind speed of 46.1 m/s), causing severe agriculture, forestry, and the social economy. In the present study, we evaluated the impact of the super typhoon Sarika on vegetation by performing NDVI (Normalized Difference Vegetative Index) difference analysis using MODIS multi- temporal images acquired before and after the typhoon. The assessment of typhoons depends on the land use types, landscape topography of slope, aspect, and altitude. The results indicated that the super typhoon Sarika seriously hit forestry, agriculture, shrubs, plantations, and orchards in Hainan Island. Overall, 79% of vegetation exhibited a negative change, whereas only 21% of vegetation exhibited a positive change in NDVI after the super typhoon Sarika. Agriculture (including dry land and paddy field agriculture) was most severely damaged by the typhoon, where more than 81% of areas exhibited a decrease in NDVI, followed by plantations and orchards, where 77% of areas exhibited a decrease in NDVI. Additionally, the damage to vegetation due to typhoons was affected by abiotic factors such as altitude, slope, and aspect. Our study reported that damage due to the super typhoon was associated with land cover types, altitude, aspect, and slope. In low altitude plain and coastal areas, NDVI decreased more in this super typhoon Sarika, consistent with the distribution of typhoon gale. Additionally, the current study demonstrated that MODIS images with a spatial resolution of 250 m could rapidly evaluate quantitative and accurate vegetation damage from the macro scale.
Clinical characteristics, socioeconomic factors and COVID-19 were associated with delayed surgery in children with hypospadias: a retrospective study of 4439 cases in a single center
Authors: Bai Gaochen , Liang Feng , Zhao Tianxin , Deng Fuming , Fu Kai , Chen Xiong , Li Zhongmin , Zhang Liyu , Jia Wei , Fu Wen , Liu Guochang
Published: March 2022

Background Hypospadias is one of the most common congenital diseases of the genitourinary system in children. The European Association of Urology (EAU) Guidelines recommend that children undergoing hypospadias surgery should be between 6-18 months. In China, where many children have hypospadias, it remains unknown whether clinical characteristics, socioeconomic factors and COVID-19 were associated with delayed surgery in children with hypospadias.Methods We retrospectively analyzed children with hypospadias who underwent primary surgery at the Department of Pediatric Urology in Guangzhou Women and Children’s Medical Center between January 2010 and October 2021. Patients who had two-stage surgery or a second round of surgery due to complications were excluded to eliminate data duplication. The clinical characteristics and demographic information were collected. We defined delayed surgery as primary surgery performed after 18 months following the EAU guideline.Results A total of 4439 children diagnosed with hypospadias were included in the study. The median age (29.1±16.7 months) of surgery for hypospadias in our study was much higher than the recommended age reported in the EAU guidelines, and 76.6% of the children underwent surgery after the age of 18 months. Children without comorbidities including cryptorchidism (odds ratio [OR]=1.562; 95% confidence interval [CI]1.199-2.034; p=0.001), prostatic cyst (OR=2.613; 95% CI 1.579-4.324; p<0.001), penile hypoplasia (OR=1.778; 95% CI 1.225-2.580; p=0.002), inguinal hernia (OR=2.070; 95% CI 1.394-3.075; p<0.001), and penoscrotal transposition (OR=4.125; 95% CI 1.250-13.619; p=0.020) were more likely to receive delayed surgery. Living in a low economic area (OR=1.731; 95% CI 1.068-2.806; p=0.026) or not close to a main medical center (OR=1.580; 95% CI 1.370-1.824; p<0.001) was highly associated with delayed surgery. The proportion of children undergoing delayed surgery and the median age of surgery during the COVID-19 pandemic were significantly higher than those before the COVID-19 pandemic (p=0.004 and < 0.001, respectively).Conclusions Most children with hypospadias received delayed surgery (surgical age >18 months). Comorbidities, living in a low economic area, too far from a major city medical center and the COVID-19 pandemic were also highly associated with delayed surgery. It is vital to improve the public awareness of hypospadias and strengthen the re-education of primary community doctors to reduce delayed surgery. Trial registration Not applicable.
Variable Range Hopping (VRH) charge transport and Poole-Frenkel type conduction mechanism of polypyrrole synthesized with Chemical Oxidative Polymerization
Authors: Balu Gowtham , v Balasubramani
Published: March 2022

Polypyrrole (PPy) was prepared with various weight loadings of acetic acid (10, 30 and 50 wt.%) over chemical oxidative polymerization. The structural and electrical properties of the prepared samples were characterized by XRD and electrical analysis. The charge transport mechanism of PPy was executed by Keithley (6517B) equipment performed between a voltage of 1 to 10 V by the increment of 1 V. The current over capacitor as a role of the applied voltage was carried out from 303 to 403 K temperature range. The XRD result confirms the amorphous nature of PPy. The charge transport process of PPy was deliberated by Mott’s variable-range hopping (VRH) through the conductivities and they found using various weight loadings of acetic acid. The conductivity (σdc) was found to increase with the temperature increase, which indicates the semiconducting nature and the conductivity value calculated was 10− 9 to 10− 7 S/cm for various weight loadings of acetic acid. The I-V study outcomes the linear behavior and the semiconducting nature of PPy, and the study was completed by the explanation of the Poole-Frenkel type conduction mechanism, ln (J) vs. T plots in PPy samples at high fields. It concludes that the comparison of theoretical field-lowering coefficients βS and βPF and the experimental field-lowering coefficients βS and βPF were correlated and the result confirms the Poole-Frenkel type conduction mechanism in PPy. The activation energy diminishes from 1.22 to 1.07 eV with an increase of acetic acid weight percentage.
Sex Specific Cardiometabolic Risk Markers of Left Ventricular Mass in Physically Active Young Adults: The CHIEF Heart Study
Authors: Tsai Kun-Zhe , Liu Pangyen , Huang Wei-Chun , Lima joao , Lavie Carl J. , Lin Gen-Min
Published: March 2022

Background: Greater physical fitness may lead to greater left ventricular mass (LVM) and reduce the effect of cardiometabolic risk factors on LVM. However, the cardiometabolic biomarkers associations for LVM have not been clarified in physically active young adults. Methods: This study included 2,019 men and 253 women, aged 18-43 years, from the military in Taiwan. All participants underwent anthropometric and blood metabolic markers measurements, and completed a 3000-meter run test for assessing fitness. LVM was calculated on the basis of an echocardiography. Multiple linear regression was used to determine the sex-specific associations between cardiometabolic risk markers and LVM indexed for the body height (g/m2.7). Results: In men, age, systolic blood pressure (SBP), 3000-meter running time, serum triglycerides, serum uric acid and waist circumference (WC) were correlated with LVM index (β =0.073, 0.099, -0.005, 0.005, 0.237 and 0.237, respectively; all p-values <0.05). The correlations were not significant for fasting glucose, total cholesterol and high-density lipoprotein cholesterol (HDL-C). In women, SBP, HDL-C and WC were correlated with LVM index in the univariate analysis (β =0.066, -0.050 and 0.318, respectively; all p-values <0.05), whereas the correlation was merely significant for WC in the multiple linear regression analysis (β =0.197; p-value <0.001). Conclusions: In physically active adults, the associations of cardiometabolic risk markers with LVM might vary by sex. Greater physical fitness associated with greater LVM was noted only in men, while greater WC was the only metabolic risk marker for greater LVM in both men and women.
The computational age-at-death estimation from 3D surface models of the adult pubic symphysis using data mining methods
Authors: Kotěrová Anežka , Štepanovský Michal , Buk Zdeněk , Brůžek Jaroslav , Techataweewan Nawaporn , Velemínská Jana
Published: March 2022

Age-at-death estimation of adult skeletal remains is a key part of biological profile estimation, yet it remains problematic for several reasons. One of them may be the subjective nature of the evaluation of age-related changes, or the fact that the human eye is unable to detect all the relevant surface changes. We have several aims: 1) to validate already existing computer models for age estimation; 2) to propose our own expert system based on computational approaches to eliminate the factor of subjectivity and to use the full potential of surface changes on an articulation area; and 3) to determine what age range the pubic symphysis is useful for age estimation. A sample of 483 3D representations of the pubic symphyseal surfaces from the ossa coxae of adult individuals coming from four European (two from Portugal, one from Switzerland and Greece) and one Asian (Thailand) identified skeletal collections was used. A validation of published algorithms showed very high error in our dataset – the MAE ranged from 16.2 and 25.1 years. Two completely new approaches were proposed in this paper: SASS (Simple Automated Symphyseal Surface-based) and AANNESS (Advanced Automated Neural Network-grounded Extended Symphyseal Surface-based), whose MAE values are 11.7 and 10.6 years, respectively. Lastly, it was demonstrated that our models could estimate the age-at-death using the pubic symphysis over the entire adult age range. The proposed models offer objective age estimates with low estimation error and are able to estimate the age using the pubic symphysis across the entire adult age range.
Novel Lipid Metabolism-Related Gene Signature Associated with Clinical and Immune Features in Lung Adenocarcinoma Patients Experiencing Lymph Node Metastasis
Authors: Lao Shen , Chen Zisheng , Xiong Yaming , He Miao , Zheng Yongmei , Liu Xiaoyan , Zhang Jingna , He Jianxing , Liang Wenhua
Published: March 2022

Background: Accumulating evidence revealed that lipid metabolic reprogramming facilitates lymph node metastasis and cancer progression. This study aimed to perform comprehensive bioinformatic analyses of the lipid metabolism-related impact in lung adenocarcinoma (LUAD) patients experiencing lymph node metastasis (LNM). Methods: Clinicopathological information and RNA-sequence data on LUAD patients were collected from the TCGA and GEO databases. Subsequently, 189 differentially expressed lipid metabolism-related genes (LMRGs) were screened for LUAD patients with and without LNM. Based on the risk scoring system related to prognosis, we further correlated the LMRGs with diverse clinicopathological outcomes, genomic alterations, and immune features, as well as immunotherapeutic responses and drug susceptibility.Results: A three-gene lipid metabolic signature (GPD1L, SPHK1, and ST3GAL4) associated with tumor progression in LUAD with LNM was identified. Analyses revealed that the high-risk group had worse overall survival; an increased proportion of M0 macrophages and degranulating mast cell infiltration; increased non-responders to immunotherapy; and resistance to several common TKI drugs. Interestingly, we also found that high-risk patients had higher tumor mutation burdens and PDL-1 expression, suggesting that this subset of patients may benefit from immunotherapy plus LMRG-targeted therapy. Additionally, the results showed that the high-risk group's differentially expressed genes (DEGs) were enriched in the REACTIVE OXYGEN SPECIES pathway. Conclusions: Our findings may provide new insights into molecular mechanisms and precision therapies of lipid metabolism-related LUAD regional metastasis.
Diagnosing disseminated histoplasmosis in advanced HIV/AIDS disease in Cameroon using a point of care lateral flow assay – a case series
Authors: Kuate Marius Paulin Ngouanom , Abessolo Hermine Abessolo , Denning David W. , Stone Neil R. , Ndip Roland Ndip
Published: March 2022

Background
Histoplasmosis is an AIDS-defining opportunistic infection. Disseminated histoplasmosis (DH) can be fatal without early diagnosis and treatment initiation. We present four cases of disseminated histoplasmosis in advanced HIV/AIDS disease patients diagnosed using Histoplasma lateral flow assay (LFA) in Yaoundé, Cameroon.
Cases presentation
: Four women with HIV but unknown CD4 + T cell count were received at the Hospital presenting with asthenia, weight loss, productive cough and fever (39°C) as common symptoms for at least three weeks. Two of the patients had skin lesions. These included facial papules, macules and umbilicated vesicles scattered over the trunk and limbs. These were diffuse lesions which were purulent, itching and papillomatous lesions with a necrotic center, and one patient had a right forearm ulcer. We performed the Histoplasma antigen tests using the Histoplasma antigen lateral flow assay (LFA) and they were strongly positive in all four patients. Histopathology in skin biopsy allowed identification of the species as Histoplasma capsulatum var capsulatum in one patient. In this same patient, Pseudomonas aeruginosa and Proteus mirabilis were cultured from the forearm ulcer. This patient later commenced antibiotics (Levofloxacin 500 mg) and oral itraconazole (800mg/day) with immediate improvement. Unfortunately, the other three patients could not afford itraconazole, were discharged and lost to follow up.
Conclusion
Early diagnosis and treatment are essential for the management of DH. LFA is a test that can be set up in any setting with limited resource. Access to this can be a major advance in the diagnosis of histoplasmosis in resource limited settings.
Left atrial mechanics and functional capacity in HFpEF pts with paroxysmal atrial fibrillation
Authors: Kodeboina Monika , Katbeh Asim , Penicka Martin , Verstreken Sofie , Vanderheyden Marc
Published: March 2022

Introduction: Patients(pts) with paroxysmal atrial fibrillation are at risk for developing heart failure with preserved ejection fraction(HFpEF) and often have an impaired exercise capacity. Since left atrial (LA) pressure plays a major role in the exercise intolerance, we aimed to characterize the contribution of resting LA mechanical properties, assessed by two-dimensional speckle tracking echocardiography upon exercise capacity. Purpose: To evaluate relationship between LA mechanics, measured by LA strain (LAS) and parameters of exercise capacity in pts with paroxysmal atrial fibrillation. Methods: The study included 54 pts(64 ± 10years, 76 % males) with dyspnea (NYHA³II), paroxysmal atrial fibrillation and preserved LV ejection fraction (≥50%). The likelihood of HFpEF was estimated using H2FPEF score. During sinus rhythm, all patients underwent speckle tracking echocardiography and cardiopulmonary exercise testing (CPET). Peak oxygen uptake(VO2peak) served as measure of functional capacity and ventilation/carbon dioxide output slope(VE/VCO2) as surrogate of ventilation/perfusion mismatch. Results: LA contractile strain(S) and strain rate(SR) showed significant correlation with VO2peak(both p < 0.05). LA reservoir, conduit and contractile LAS, all had significant relationship with VE/VCO2 slope (all p<0.050). Pts with LASR above the median had significantly higher VE/VCO2 (p=0.025) and lower VO2peak(p=0.010). In contrast, no correlations were observed between exercise parameters and LA volumes or any other echocardiographic indices. Conclusions: In HFpEF VO2peak and VE/VCO2 are closely related to LA contractile strain, suggesting that abnormalities in LA mechanics may contribute to the blunted exercise capacity. Therefore, we speculate that these markers can be used as an echocardiographic surrogate of functional capacity in HFpEF pts. Further studies are warranted.
Increased expression of NXNL1 in breast cancer associated with favorable prognostic and high level of immune infiltration.
Authors: Gao Hui , Lv Liqiong
Published: March 2022

Objective: Nucleoredoxin Like 1 (NXNL1) is a protein coding gene. Diseases associated with NXNL1 include Retinitis Pigmentosa. However, the roles of NXNL1 in cancer remain unknown. Methods: The expression of NXNL1 was interpreted by The Cancer Genome Atlas (TCGA) database and Genotype Tissue-Expression (GTEX) database. Analysis of NXNL1 genomic alterations and protein expression in human cancer tissues was analyzed by the cBioPortal database and human multiple organ tissue arrays. The correlations between NXNL1 expression and survival outcomes, clinical features, and immune-associated cell infiltration were analyzed using the TCGA, ESTIMATE algorithm, and TIMER databases. Gene Set Enrichment Analysis (GSEA) was applied to elucidate the biological function of NXNL1 in pan-cancer. We evaluated the influence of NXNL1 on survival of BC patients by survival module. Then, data sets of Breast Cancer were downloaded from TCGA. The correlations between clinical information and NXNL1 expression were analyzed using logistic regression. Clinicopathologic characteristics associated with overall survival in TCGA patients using Cox regression. In addition, we explored the correlation between NXNL1 and cancer immune infiltrates using CIBERSORT and “Correlation” module of GEPIA. Results: The differential analysis showed that the level of NXNL1 mRNA expression was upregulated in 23 tumor types compared with normal tissues, which was consistent with its protein expression in most cancer types. The abnormal expression of NXNL1 could predict the survival outcome of patients with breast cancer (BC). The expression of NXNL1 was related to the infiltration levels of various immune-associated cells in breast cancer by TIMER database mining and ESTIMATE algorithm. wherein NXNL1 expression used as the categorical dependent variable, indicated that increased NXNL1 expression is significantly correlated with ER status, PR status, and HER2 status. Moreover, univariate and multivariate analysis revealed that the up-regulated NXNL1 expression is independent prognostic factors for good prognosis. Specifically, a positive correlation between increased NXNL1 expression and immune infiltrating level of the abundance of B cells, Neutrophils, Mast cells and NK cells was established using CIBERSORT analysis. Furthermore, we confirmed it in “correlation” module of GEPIA. Conclusion: Our results suggest that NXNL1 is a potential molecular biomarker for predicting patient prognosis, and immunoreaction in Breast Cancer.
A Colorimetric and Fluorescent Dual-Signal Sensor for Detecting Lipase Activity Based on Inner Filter Effect
Authors: Du Ting , Zhang Fu , Jiang Ling , Tian Danbi
Published: March 2022

We developed a colorimetric and fluorescence dual-signal sensor for detecting lipase activity based on methyl thioglycolate (MT) functionalized gold nanoparticles (MT-AuNPs) and CdS quantum dots (CdS QDs). It is the first time that was developed a dual-signal sensing strategy for lipase activity based on the inner-filter effect (IFE) between MT-AuNPs and CdS QDs. This probe system (MTAuNPs + CdS QDs) is sensitive and has selective response to the concentration of the lipase, and MT-AuNPs and CdS QDs played as transducer and fluorescer, respectively. The addition of lipase triggered the accumulation and change of color in CdS QDs and MT-AuNPs solution, it also makes CdS QDs’ fluorescence intensity significantly recover. The limit of detection (LOD) was as low as 0.039 μg mL-1 for colorimetric detection as well as 0.012 μg mL-1 for the fluorescence method. This method has been successfully used in the detection of commercial lipases. We believe it would open up a new path for the sensitive and high throughput lipase assay using nanobiosensor.
Pośrednictwo Kościoła w myśli Paula Tillicha
Authors: Walczak Marcin
Published: March 2022

Pośrednictwo Kościoła stanowi dziś dla wielu osób wierzących trudność, szczególnie w kontekście pewnego kryzysu wizerunkowego kościelnych instytucji. Dlatego tak istotne jest, by pokazywać teologiczne podstawy i zasady pośrednictwa Kościoła w dziele zbawienia człowieka. Niniejszy artykuł czyni to, analizując pod kątem idei pośrednictwa eklezjologię Paula Tillicha, jednego z wielkich teologów protestanckich XX wieku. Takie spojrzenie na myśl protestanckiego uczonego pozwala zrozumieć, że nie ma teologii chrześcijańskiej bez pośredniczącej roli Kościoła. W pierwszej części przeanalizowane zostanie pojęcie Kościoła jako Duchowej wspólnoty. Następnie ukazana zostanie pośrednicząca rola Kościoła w jego funkcjach, potem zaś przedstawione będzie pośrednictwo Kościoła w duchowym wzroście chrześcijanina. Pośrednicząca rola Kościoła opiera się na fundamencie działania Ducha Świętego i dotyczy w pierwszej kolejności pośrednictwa wspólnoty wiary, a nie jakichś konkretnych rozwiązań instytucjonalnych.
Análise de falha de uma linha de eixo de transmissão pertencente a um descarregador de barcaças instalado no Terminal Salineiro de Areia Branca/RN
Authors: Pinheiro Raniel Azevedo , Cavalcante Fabrício José Nóbrega
Published: March 2022

A análise de falhas consiste em um conjunto de ações com o objetivo de analisar as não conformidades ocorridas em componentes e equipamentos pertencentes a um determinado processo, para encontrar e mitigar as causas raiz dos problemas em questão. Este tipo de estudo é presente na área de manutenção desde o ano de 1949, quando engenheiros militares dos Estados Unidos da América (EUA) trabalhavam na confiabilidade dos seus sistemas e equipamentos. Dessa forma, foi proposta a obtenção da causa raiz de uma falha ocorrida, bem como a análise de outras possíveis falhas de uma linha de eixo de transmissão responsável pela translação do Trolley(casaria fabricada em chapa de aço, contendo rodas, equipamentos mecânicos e elétricos responsáveis por seu movimento sob trilhos) de um descarregador de barcaças pertencente ao Terminal Salineiro de Areia Branca/RN. Aplicando a metodologia das ferramentas de análise de falhas cinco porquês e FMEA, foi possível identificar a causa raiz do rompimento do eixo, que se deu na falta de programação de manutenção preventiva do equipamento, e levantar todas formas como o equipamento pode falhar e seus efeitos, gerando um conjunto de atividades preventivas e preditivas a fim de eliminar os riscos.
Unknown Extra-Articular Manifestation of Spondyloarthritis: What
About Retroperitoneal Fibrosis? A Case Based Literature Review
Authors: Boussaid Soumaya , Majdouba Marouene Ben , Rekik Sonia , Jammali Samia , Cheour Elhem , Sahli Hela , Elleuch Mohamed
Published: March 2022

Introduction:

Retroperitoneal fibrosis (RPF) is a rare disease characterized by fibro-inflammatory tissue proliferation in the retroperitoneum. It results in a chronic inflammatory and fibrosis condition, possibly leading to compression of the retroperitoneal structures, especially to encasement of the ureters and the inferior vena cava. It may have an idiopathic or a secondary origin. Spondyloarthritis (SpA) is one of the rare conditions described among the secondary forms.

Case:

Herein, we report a new case of RPF in a patient with AS. Who presented with acute abdominal pain radiating to the lumbar region and the left testicle. On clinical examination, we found a mild stiffness of the lumbar spine and a decrease in chest expansion. Sacroiliac joint pain was also found. The rest of the physical examination was normal. Laboratory tests showed inflammation with increased C-reactive protein (130 mg/l) and creatinine (112 micromol/l) levels. The computed tomography scan revealed a soft tissue density mass located around the sub-renal aorta. Diagnosis of idiopathic RPF associated with AS was retained. The patient was treated by a daily dosage of 1 mg/kg of oral glucocorticoid with good outcome.

Conclusion:

RPF is a rare condition that can be either idiopathic or secondary. Its association with spondyloarthritis, mainly in its ankylosing spondylitis form, seems to be more than anectodal. Treatment may involve medical therapy and/or surgical management.

Key message:

In the presence of back pain, fatigue, weight loss, and low grade fever in spondyloarthritis patients, physicians should screen for retroperitoneal fibrosis as it could be a possible cause.
A SYSTEMATIC LITERATURE REVIEW OF LEAN SIX SIGMA IN VARIOUS INDUSTRIES
Authors:   Program Studi Teknik Industri Universitas Mercu Buana, Kurnia Hibarkah , Purba Humiras Hardi
Published: March 2022

The Lean Six Sigma / LSS approach has received a lot of attention in various industrial sectors, from the manufacturing industry to the service industry. More specific knowledge about Lean Six Sigma has grown rapidly. Much of the training and research on Lean Six Sigma is carried out in various industries. This literature review is related to LSS's purpose to provide an overview of Lean Six Sigma implementation in the manufacturing industry. The Lean Six Sigma approach introduced and implemented for a long time is DMAIC (Define, Measure, Analyze, Improve, and control). This paper discusses the published literature related to Six Sigma ranging from 2015 to 2020. This paper involves the study review of 50 papers related to the implementation of LSS of known database search, including Google Scholar, Elsevier, Science Direct, and other worldwide publishers. This literature review contains results from a variety of different perspectives. The perspective includes the focus of the industry, the focus of the number of distribution by country, the focus of the year of publication, and the number of publishers. This is useful for all types of manufacturing industries to find solutions to problems. The paper also provides advantages for researchers next to add to the literature.
INDUSTRIAL ECOLOGY AS THE PRECURSOR GRAND THEORIES TO CIRCULAR ECONOMY: BIBLIOGRAPHIC MAPPING OF 112 LITERATURE
Authors:   School of Business and Management Institut Teknologi Bandung, Sitadewi Dania , Yudoko Gatot , Okdinawati Liane
Published: March 2022

Environmental degradation require business to rethink their way of doing business. Industrial Ecology (IE) is a paradigm change that allows a cyclical resource-use in which Circular Economy (CE) rethink and recycle the waste generated into a industrial input, thereby reducing environmental burden. Industrial Ecology (IE) is one of the most referenced grand theories for Circular Economy (CE). This research aims to map IE to CE bibliographically to identify research trends, prominent researchers, and countries with the most publication. This research's methodology is bibliographic mapping of 112 articles using VOSviewer in three steps: data acquisition, data processing, and visual output. This research has identified three research findings. The first finding is the identification of five clusters that correspond with the current research trend. The second finding is identifying Geng Y., Lai K.H., and Zhu Q. as the leading researchers for CE and IE. The third finding is China is the leading country for CE and IE research. The implication is China aiming to transform its industry into environmentally more sustainable. Future research topic venue can incorporate other grand theories to expand the theoretical and practical focus of CE.
COMPARISON OF THE REQUIREMENTS FOR CANDIDATE FOR PRESIDENT AND MEMBER OF HOUSE OF REPRESENTATIVE IN THE ELECTION LAW (BASED ON THE PERSPECTIVE OF PANCASILA)
Authors: Susmayanti Riana
Published: March 2022

Ideally, the President and House Of Representative are free from nepotism, collusion and corruption in accordance with Law No. 28 of 1999 concerning State Adinistrators Who Are Clean And Free From Corruption, Collusion And Nepotism. However, Law No. 7 of 2017 concerning General Election imposes different conditions between candidate for President and member of House Of Representative. Former corruptors are prohibited from running for President, but can run for the member of House Of Representative on condition that they announce their status as convicted of corruption. This normative juridical research will analyze the unequal requirements of candidate for President and members of House Of Representative, while the positions for the state institutions are equal. The conceptual approach is used to analyze the requirements of candidate for President and members of House Of Representative. Primary legal materials collected through library research include statutory regulations. Furthermore, extensive and systematic (logical) interpretations are used to analyze requirements of candidate for President and members of House Of Representative in various laws and values of Pancasila.
Reinterpretation of Nationalism with Matrix Theory Approach
Authors: Saraswati Destriana , Zakiyah Millatuz , Zulvarina Prima
Published: March 2022

This research trying to reinterpret and redefine the concept of nationalism by using the Matrix Theory method approach. Given the changing patterns of society, efforts to reinterpret the meaning of nationalism are important to maintain collective understanding of one of the main elements of national unity. The concept of nationalism may be close to people's lives in general, but confusion and differences of opinion often arise when describing it in the public. The choice of the Matrix Theory method, which is one of the qualitative research models, is because there have been many figures who have defined nationalism from various perspectives. In addition, this method was chosen because it is useful for streamlining diverse, multi-meaning, and abstract theories or definitions; to avoid defining exhibitions or parades that are not particularly relevant. The results of this research are in the form of interpretations or interpretations of the concept of nationalism that are more in line with current developments.
The Ordeal of a Sixth-Century Josef K: Boethius’ De Consolatione Philosophiae as a Modernist Drama
Authors: Gerbrandy Piet S. , Gerbrandy Piet S.
Published: March 2022

In recent scholarship, several views have been propounded on the argumentative inconsistencies in Boethius’ De consolatione Philosophiae and the inconclusiveness of its ending. In this article, it is argued that modern scholars still, perhaps unconsciously, adhere to aristotelian concepts of unity, coherence, and closure, which may not be helpful in assessing what Boethius is really trying to say. When analysed from a perspective usually associated with modernist literature, it becomes clear that Boethius’ swan song is neither a deconstruction of “pagan” philosophy nor an implicit plea for Christian spirituality but a an existential drama in which religion and philosophy do not provide any consolation.
Pedagogical Communication in Nigerian Children Literature: A Pragma-Semiotic Study of Akintayo Oluyinka’s The Greatest Mistake
Authors: Emike Acheoah John , Sani Abdullahi , Umar M. Aisha , Wara Aisha Usman
Published: March 2022

This study is a cross-disciplinary investigation of the pedagogical significance of children literature in Nigeria—a linguistic study of selected samples from Akintayo Oluyinka’s The Greatest Mistake. Visual illustrations are typical of children literature because of the age-range of the readers. Hamilton (2000) notes that “children who encounter excellent picture books learn how to read not just the moods but also the pictures. They pay close attention to what they see often discovering things in illustrations.” Like in the literary text we examine in this study, pictorial illustrations in Nigerian children literature have varied contextual underpinnings which make them have meanings to children-readers. This establishes their pragmatic relevance. Objects and gestures convey messages in discourse. Therefore, semiotics is a crucial concern of this study. Hinging on the Pragma-crafting theory, this study concludes that the effectiveness of children literature in the transmission of knowledge to the target readers (children) depends on the skillful use of textual and extra-textual elements of communication.
Philippine Farmers Adaptation of Hybrid Rice Technology to Increase Profitability and Contribute to Rice Sufficiency
Authors: C. Abao Dei Chiara , M. Aquino Jose Carlo , Guzman Amiel C. De , Francisco Adona Mae , A. Rafa April , B. Cruz Jocelyn
Published: March 2022

This study explored the adaptation of Filipino farmers to using hybrid rice and its farming technology. A sample of 100 respondents was selected through convenience sampling. Data were collected mainly through a questionnaire (digitalized online survey) distributed to the targeted groups. The findings revealed that most of the farmers chose to plant both inbred and hybrid rice seeds during the wet and dry seasons even knowing that hybrid rice varieties have a higher yield potential than inbred seeds. The study also revealed that after planting hybrid rice seeds, farmers’ yield increased significantly that has positively affected their income. The major challenge the farmers is facing is the high cost of hybrid rice seeds and farm inputs. It is recommended that farmers should try using hybrid rice seeds in farming and further request the government to provide them more subsidies for it. They should also attend trainings about hybrid rice production to equipthem about the latest technology in farming.
Es mujer porque María es mujer
Authors: De Materiales Orales Laboratorio Nacional
Published: March 2022

Esta grabación forma parte de la investigación realizada por el LANMO a través del proyecto CONACyT Materiales orales de la zona lacustre michoacana: documentación, procesamiento y análisis. Se realizó en la casa de Demetria Antonio Guzmán, habitante de la Isla de Pacanda, ubicada en el municipio y lago de Pátzcuaro.

Datos de la entrevista

Fecha: 06 de septiembre de 2015

Duración: (1:03:09)

Personas presentes: Itzi Palomares, Berenice Granados, Georgina Alanis, Adela Rascón, Yunuén Barbosa, Yotzin Viacobo, Abraham Montañés, Santiago Cortés, Quetzal Mata

Lugar (espacio concreto) en el que se llevó a cabo: Casa de Demetria

Medio de grabación: Sony HXR NX70

 

Datos del narrador

 

Nombre: Demetria

Apellidos: Antonio Guzmán

Sexo: Femenino

Año de nacimiento: 1943

Lugar de nacimiento: Isla Pacanda, Mich.

Lengua materna: Purépecha

Otras lenguas: Español

¿Sabe leer y escribir? (especificar): No sabe leer ni escribir

Estado civil: Casada

Transcrito por: Georgina Alanis, Berenice Granados, Bianca Pizano, Adela Rascón
Antonio Analco Sevilla y Alberto Diez Barroso Repizo, coords. Lectores de la naturaleza. Memorias de un hacedor de lluvia. México: Secretaría de Cultura, 2016; 107 pp.
Authors: Viacobo Huitrón Yotzin Nekis
Published: March 2022

Este estudio, dividido en seis capítulos, abre con las palabras de “la figura del hombre del conocimiento”, Antonio Analco Sevilla, tiempero de San Nicolás de los Ranchos, en Xalitzintla, Puebla, una de las comunidades ubicadas en las inmediaciones del volcán Popocatépetl. Su relato comienza en la infancia, cuando tuvo su primer encuentro y comunicación onírica con el volcán, Gregorio Chino Popocatépetl, y con la volcana, Rosita. Desde ese momento, el sueño fue el medio para aprender el saber ancestral.

En los episodios siguientes, cinco especialistas del Instituto Nacional de Antropología e Historia y de la Escuela Nacional de Antropología e Historia analizan la labor de Antonio como mediador entre las entidades naturales y Xalitzintla, pero también su labor en los pueblos aledaños a don Goyo, donde la siembra necesita la lluvia. Mediante una etnografía del ascenso a “el ombligo” del volcán, la ofrenda y ceremonia comunitarias, las plegarias, la comida y la fiesta, de acuerdo al ciclo ritual agrícola, somos testigos de las fechas importantes vinculadas con las entidades de la tierra, en las que el pueblo celebra al volcán.

Un pasaje del texto está dedicado a la Matlalcueye o “Malinche”, para poner de manifiesto que la veneración a los cerros pervive en el valle poblano-tlaxcalteca y forma parte de la cosmovisión mesoamericana. Incluye también una breve historia de la religión mesoamericana concretizada en el evento de petición de lluvias en la huasteca veracruzana, un dossier fotográfico que ilustra, entre otras cosas, algunos episodios de la ceremonia, monumentos, trazos arquitectónicos y representaciones antiguas asociadas al agua.

El texto finaliza con el análisis el territorio, su simbolismo sagrado, el espacio y las concepciones por las cuales está constituido, con el objetivo de mostrar cómo los espacios son emblemáticos, pues los seres sobrenaturales moran y se revelan en mitos y creencias. Por ello, el carácter sacro del culto a los cerros es de renovación constante entre entidades y hombres.
Ángeles Rubio Tapia, ed. Ven a bailar conmigo… El “baile de golpe” en cuatro municipios de Tierra Caliente. México: PACMYC/URCPI Michoacán/CNCA. 2014, 152 pp.
Authors: Estrada Hernández Daniel
Published: March 2022

En este libro, María de los Ángeles Rubio Tapia nos habla del baile de golpe que se realiza a lo largo de la zona de Tierra Caliente, tanto en Michoacán como en Guerrero, presentando los frutos de varios años de trabajo de campo hecho en las localidades de Arteaga, Apatzingán, Coahuayutla y Zicuirán, La Huacana. En una primera parte y con el apoyo de varias entrevistas presentadas con una descripción muy ligera pero a la vez erudita, Ángeles Rubio nos da a conocer y reconocer qué es el “son”, en cuáles celebraciones se baila, cuál es la historia de los músicos, la instrumentación, la tabla –elemento fundamental para la realización para el baile de golpe-- y los bailadores. En un segundo momento realiza, con una sistematización única para este tipo de expresión, la descripción de las danzas, los pasos característicos de cada danzante y sus funciones dentro de su realización.

El libro contiene también un DVD como material complementario en el que se presenta dos documentales realizados por la misma Ángeles Rubio. El primero se titula igual que el libro y mantiene la misma estructura de este, lo que permite apreciar de manera más concreta los detalles de la instrumentación, ritmos, bailadores y los pasos que se describen en los diversos esquemas. El segundo tiene por nombre Son de la tierra y está conformado por diversas entrevistas y muestras musicales que inundarán al lector del ritmo de Tierra Caliente y de la empatía necesaria para entender la importancia dancística y musical de este territorio.
DAMPAK KREDIT PT PNM MEKAAR TERHADAP KINERJA USAHA ULTRA MIKRO DI KECAMATAN BATU
Authors: Mayangsari Bunga Adelia , Zuhroh Idah , Hadi Syamsul
Published: March 2022

This study aims to analyze the performance of ultra micro businesses after obtaining venture capital financing from PT. Permodalan Nasional Madani (PNM). Judging from the performance and impact felt by ultra micro entrepreneurs in Batu District, after receiving financing from PT. PNM. This study uses primary data, with a simple regression analysis tool. The results showed that the financing program from PNM Mekaar had an impact on increasing capital, increasing turnover, increasing operating profits and increasing assets. However, this does not affect the increase in the workforce and the increase in business branches of ultra micro entrepreneurs in Batu District.