bluuebunny/crossref_metadata_2025 huggingface dataset:
“There is always a new normal”‐Psychological Transformation of Nurses ‐A Post Pandemic Qualitative Study
Authors: Joy George , Ali ALOMARI Albara Mohammad , SINGH Kalpana , MANNETHODI Kamaruddeen , HASSAN Nesiya , KUNJAVARA Jibin , PITIQUEN Ederlie Encarnacion , AL LENJAWI Badriya
Published: September 2023

Background Coronavirus disease 2019 (COVID-19) almost ceased to spread across the globe, but post Covid psychological experiences are rarely documented. It is essential to understand the individual psychological needs and challenges regarding working during the covid-19 pandemic and resilience and psychological health to continuing work in the aftermath of this crisis. Objective To explore the psychological transformation of staff nurses after COVID-19 Methods A phenomenological and purposive sampling approach was employed. Registered nurses working at the largest health organization in Qatar includes 14 health facilities were invited to participate in this study. 17 nurses who were working in the facilities and were deployed during the first, second and third wave of Covid 19 participated in the interview. Data were collected through semi-structured face-to-face interviews using quarantine measures. The interview data were analyzed using inductive thematic analysis. Results The psychological transformation of participants was summarized into three themes fear zone, Learning zone and growth zone. These themes were classified into 10 sub-themes Fear and anxiety, Influence of media and news, Frequent change in policies and guidelines were the fear zone factors .Secondly Coping mechanism, teamwork, establishing compassionate care, social acceptance, personal and professional benefits helps them learn psychologically. Thirdly growth factors such as confident & resilient, Sense of purpose and Change life perception and meaning Conclusion Working during COVID-19 imposed many challenges on nurses such as workload and stress. However, the different waves of the pandemic may increase the resilience, confidence and life meaning in nurses. Their previous experiences in handling difficult situations during the pandemic may make the nurses become more confident in dealing with stressful situations and working under pressure.
Accelerating Quantum Decay by Multiple Tunneling Barriers
Authors: Longhi Stefano , Pinotti Ermanno
Published: September 2023

A quantum particle constrained between two high potential barriers provides a paradigmatic example of a system sustaining quasi bound (or resonance) states. When the system is prepared in one of such quasi bound states, the wave function approximately maintains its shape but decays in time in a nearly exponential manner radiating into the surrounding space, the lifetime being of the order of the reciprocal of the width of the resonance peak in the transmission spectrum. Naively, one could think that adding more lateral barriers would preferentially slow down or prevent the quantum decay since tunneling is expected to become less probable and because of quantum backflow induced by multiple scattering processes. However, this is not always the case and in the early stage of the dynamics quantum decay can be accelerated (rather than decelerated) by additional lateral barriers, even when the barrier heights are arbitrarily large. The decay acceleration originates from resonant tunneling effects and is associated to large deviations from an exponential decay law. We discuss such a counterintuitive phenomenon by considering the hopping dynamics of a quantum particle on a tight-binding lattice with on-site potential barriers.
Elevated fecal calprotectin accompanied by intestinal neutrophil infiltration and goblet cell hyperplasia in a murine model of multiple sclerosis
Authors: Nouri Mehrnaz , Weström Björn , Lavasani Shahram
Published: September 2023

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system caused by myelin-specific autoreactive T cells. We previously demonstrated intestinal barrier disruption and signs of inflammation in experimental autoimmune encephalomyelitis (EAE), a model of MS. Fecal calprotectin is a disease activity biomarker in inflammatory bowel diseases, released by neutrophils in response to inflammation. We aimed to further investigate EAE manifestations in the gastrointestinal tract, and to determine whether calprotectin is a useful biomarker of intestinal inflammation in EAE. Calprotectin was analyzed in feces, cecal contents, and plasma of EAE mice. Infiltrating neutrophils and goblet cells were investigated in different parts of the gastrointestinal tract, before onset of neurological symptoms and during established disease. We found increased calprotectin levels in feces, cecal content and plasma, preceding EAE onset that further escalated during disease progression. Increased neutrophil infiltration in the intestinal tissue concomitant with IL-17 expression and myeloperoxidase activity was found correlating well with clinical activity. Increased goblet cells in intestine similar to irritable bowel syndrome (IBS) were also observed. The results suggest calprotectin as a good biomarker of gastrointestinal inflammation in EAE, also the potential of this model as a useful animal model for IBS.
Psychological Inflexibility in Spanish Adults: Characteristics of Emotional Eating and the Healthy Eating Index
Authors: Arbinaga Félix , Mendoza-Sierra Maria-Isabel , Martínez-García Concha , Bernal-López Miriam , Carrasco-Rodríguez Yojanán , Moreno-San-Pedro Emilio
Published: September 2023

The aim is to understand the relationship between psychological inflexibility, emotional eating, and the rate of healthy eating. A total of 705 Spanish adults participated (65.2% women); the mean age was 27.21 years (SD = 10.67). The instruments used were Acceptance and Action Ques-tionnaire, Eating and Appraisal Due to Emotions and Stress Questionnaire and the Healthy Eating Index for the Spanish population. The women showed significantly higher scores in psychological inflexibility than men (p < .001). No differences have been described in the Emotional Eating scale (p = .085) differences have been reported on the Self-efficacy in Emotion -and Stress-Related Eating subscale, where men do better at managing eating (p < .001). Females indicate better diet quality (p < .001). Those who show less psychological inflexibility obtain emotional eating scores indicative of less coping with emotions through food (p < .001). Groups formed according to psychological inflexibility do not differ in diet quality (p = .898). The importance of psychological inflexibility is due to its role and strong association with a variety of problems related to eating behavior, but especially because it is a construct that can be intervened upon and modified.
Retrospective Analysis of a Real-Life Use of Tixagevimab–Cilgavimab Plus COVID19 Antivirals for the Treatment of Early COVID-19
Authors: Capoluongo Nicolina , Mascolo Annamaria , Bernardi Francesca futura , Sarno Marina , Mattera Valentina , Di flumeri Giusy , Pustorino Bruno , Spatarella Micaela , Trama Ugo , Capuano Annalisa , Perrella Alessandro
Published: September 2023

Tixagevimab–cilgavimab are effective for treatment of early COVID-19 among outpatients with risk factors for progression to severe illness, as well as for primary prevention and post-exposure prophylaxis. We aimed to retrospectively evaluate the hospital stay (expressed in days), prognosis, and negativity rate for COVID-19 after treatment with tixagevimab–cilgavimab.
We enrolled 42 patients who were nasal swab positive for SARS-CoV-2 (antigenic and molecular), both vaccinated and not vaccinated for COVID-19, hospitalized at the first division of the Cotugno Hospital in Naples and who received intramuscular single dose of tixagevimab-cilgavimab (300 mg / 300 mg). All patients candidates for tixagevimab-cilgavimab had immunocompromised immune system either for chronic degenerative disorders (Group A: 27 patients) or onco-hematological diseases (Group B: 15patients). Patients enrolled in group A came to our observation after 10 days from the detection of positivity to COVID-19 unlike the other types of patients enrolled in this study. The mean stay in hospital of patients in Group A was 21±5 days vs 25±5 days in Group B. Twenty patients resulted negative after a median of hospitalization stay of 16 days (IQR: 18-15.25), of them 5 (25%) patients belonged to group B. Therefore, patients with active hematological malignancy had the lower negativization rate.
Measurement of Turbidity and Total Suspended Matter in the Albufera of Valencia Lagoon (Spain) Using Sentinel-2 Images
Authors: Molner Juan V. , Soria Juan M. , Perez-Gonzalez Rebeca , Soria-Perpinya Xavier
Published: September 2023

In the context of freshwater ecosystems, turbidity and suspended solids play crucial roles, with their levels significantly influenced by anthropogenic activities. This study focuses on assessing and monitoring these parameters in Albufera de Valencia using Sentinel-2 imagery. The primary aim is to establish reliable estimation algorithms that can contribute to effective ecosystem management. The study calibrated and validated algorithms for estimating turbidity and suspended solids. The R783×R705/R490 model proved to have the best performance for estimating turbidity and total solids in the Albufera. However, R783/R490 obtained a higher coefficient of de-termination for the organic part, while the R705 band was selected for the inorganic part. However, to achieve better estimates of turbidity and inorganic matter, more research is needed in the future. The implications of excessive suspended solids are underscored, including the depletion of dissolved oxygen, and reduced primary productivity due to limited light penetration and habitat availability. Collaboration between disciplines such as limnology, optics and water chemistry are crucial to advance water quality estimation models in lakes and lagoons such as Albufera. By integrating expertise and approaches from these diverse fields, new knowledge can be gained and the basis for more effective management and conservation strategies can be laid.
A Review of Various Synthesis Methods of Graphene and Applications
Authors: S Balaji , V Madhumidha , K Haritha , A Cyril
Published: September 2023

Graphene is a two-dimensional carbon atom with a hexagonal honeycomb-like structure in which the sp2 hybridization occurs. GO sheets are highly oxidized and have oxygen-containing groups. Properties of electronics, mechanicals, magnetics, and optics, Oxidized Methods for Brodies, Staudenmaier, Hofmann, Hummers, Improved Hummers, and Tour's Methods Reduction of Graphene oxide methods Chemical Reduction using sodium borohydride, 2,4-dinitrophenylhydrazine, Hydrazine hydrate, Thermal Reduction, Hydrothermal Reduction, Exfoliation Reduction, Catalytic Reduction, and the green synthesis route for reduction, The reduction of graphene oxide has a wide range of applications, including its use in energy storage devices for Solar cells, Supercapacitors, LIG-based sensors, River Water sensors, Battery, hydrovoltaic generators, OLED Screen, and Graphene Shielding. This review will determine the future of a few applications.
Switched Auto-regressive Neural Control (S-ANC) for Energy Management of Hybrid Microgrid
Authors: Cavus Muhammed , Ugurluoglu Yusuf Furkan , Ayan Huseyin
Published: September 2023

Switched model predictive control (S-MPC) and recurrent neural network with long short-term memory (RNN-LSTM) are powerful control methods that have been extensively studied for energy management in microgrids (MGs). These methods are complementary in terms of constraint satisfaction, computational demand, adaptability, and comprehensibility, but typically one method is chosen over the other. The S-MPC method selects optimal models and control strategies dynamically based on the system’s operating mode and performance objectives. On the other hand, integration of auto-regressive (AR) with these powerful control methods improves prediction accuracy and system conditions’ adaptability. This paper compares the two approaches to control and proposes a novel algorithm called Switched Auto-regressive Neural Control (S-ANC) that combines their respective strengths. Using a control formulation equivalent to S-MPC and the same controller model for learning, the results indicate that pure RNN-LSTM cannot provide constraint satisfaction. The novel S-ANC algorithm can satisfy constraints and deliver comparable performance to MPC while enabling continuous learning. Results indicate that S-MPC optimization increases power flows within the MG, resulting in efficient utilization of energy resources. By merging the AR and LSTM, the model’s computational time decreased by nearly 47.2%. Also, this study evaluated our predictive model’s accuracy: (i) R-squared error is 0.951, indicating strong predictive ability, and (ii) mean absolute error (MAE) and mean square error (MSE) values of 0.571 indicate accurate predictions with minimal deviations from actual values.
Multiplex Portable Biosensor for Bacteria Detection
Authors: Enebral- Romero Estefania , Kaci Karim , Martinez-Periñan Emiliano , Garrido Marina , Pérez Emilio , López-Diego David , Luna Monica , González-de-Rivera Guillermo , García-Mendiola Tania , Lorenzo Encarnación
Published: September 2023

An advanced, cost-effective and portable DNA biosensor capable of detecting multiple bacteria simultaneously have been developed. The biosensor consists of a fast and inexpensive potentiostat that controls the applied potential to a screen-printed electrochemical array platform functionalized with MoS2 flakes and bacteria DNA probes, and monitors the current response obtained by the use of à la carte thionine functionalized carbon nanodots (Ty-CDs) as electrochemical indicator of the hybridization event. The design of the potentiostat prioritizes achieving an optimal signal-to-noise ratio and incorporates a user-friendly interface compatible with various devices such as computers, mobile phones and tablets. The device is compact, lightweight, and manufactured at a low cost. The key components of the potentiostat include a data acquisition board capable of analyzing multiple samples simultaneously and a controller board. The results obtained confirm the ability of the developed device to successfully detect specific bacteria DNA sequences, demonstrating the reliability and performance of the developed multiplexing portable biosensor with better sensibility than using a traditional, more complex and laboratory oriented potentiostat.
Groundwater Quality Assessment of Manipur, India, and Worldwide Bibliometric Analysis of Research Progress on Groundwater Quality
Authors: Chaudhary Rakshita , Gaur Nisha , Yadav Mohit
Published: September 2023

The water quality index (WQI) and irrigational index for groundwater were studied in the northeastern section of the Manipur Valley in northeast India. Water samples were collected in 2022 during the pre-monsoon season. To compute the water quality index for drinking water, the basic chemical parameters of total hardness, pH, electrical conductivity, total dissolved solids, Ca2+, Na+, Fe, Mg2+, Mn, Cl-, and HCO3, were used. The assessment of bacteriological quality is also done, which is crucial for overall water quality evaluation, alongside physical and chemical analyze. For determining irrigation suitability, irrigational indices such as sodium absorption ratio, sodium percentage, and magnesium hazard were calculated. WQI, %Na+, SAR, magnesium hazard, permeability Index and total hardness indicate that most water samples are harmless for irrigation and drinking purpose. They have affirmative relationships indicating that these characteristics are interdependent. Approximately 25% of the Piedmont zone groundwater is found to be unfit for agricultural and drinking usage. The encrustation of gypsum, halite, and evaporation into the Disang shares accelerate the dissolution of ions in Piedmont water, resulting in quality degradation. According to Gibbs plots, Durov Scatter Plot, and Hill Piper Trilinear Diagram of water dominated the rock-weathering process, while hydro chemical facies progressed from the beginning to the intermediate stage of Chadha's graphical representation illustrates the progression of hydro chemical processes in surface water. Therefore, proper integrated water resource management and development are required for effective water resource utilization, particularly around the Piedmont zone. To prevent a water crisis, groundwater resources must be managed sustainably. The current study also concentrated on a bibliometric examination of groundwater management and access to gauge the state of the field.
An Assessment of Long-term Climate Change on Building Energy in Indonesia
Authors: Shah Sheikh Khaleduzzaman , Harrington Philip , Graham Peter , Burton Craig
Published: September 2023

This paper reports modelling outcomes for improvements to building energy performance in Indonesia. Long-term climate effects due to building energy demands including carbon emissions are also considered. The global change assessment model (GCAM) was used to generate the related end-user building energy data, including socioeconomics for urban areas of Indonesia. As a comprehensive study, the total life cycle of carbon in the building sector and the concept of zero-carbon buildings, including energy efficiency, zero-emissions electricity and fuel switching options were considered. Building shell conductance (u-value) of building envelope, floor area ratio (FAR), air conditioner (AC) efficiency, electrical appliances (APLs) efficiency, rooftop photovoltaic (PV) performance and ground source heat pump (GSHP) systems were considered as parameters to mitigate carbon emissions under the operational energy category in GCAM. Carbon mitigation associated with the cement production process was considered in the raw material category. Urban population and labour productivity in Indonesia were used as base inputs with projected growth rates to 2050 determined from available literature. Low growth rate ‘LowRate’ and high growth rate ‘HighRate’ were considered as variable inputs for u-value, FAR, AC efficiency, APLs efficiency, and PV capacity factor to model emissions mitigation. The energy consumption of the GSHP was compared to the conventional reverse cycle ACs to identify the potential of the GSHP as a fuel-switching option. Only base input data were used for cement production process parameters without applying any variable inputs. GCAM base scenarios based on input data only (without modifying variable data) for the residential building sector in Indonesia were considered the benchmark for this study. Total potential carbon emissions mitigation was found to be 432 Mt CO2-e for the residential building sector in Indonesia over 2020-2050. It was found that an average of 24% carbon emissions mitigation could be achieved by 2020-30 and 76% in 2031-2050.
Effect of Food Restriction on Food Grinding in Brandt’s Voles
Authors: Dai Xin , Han Yu-Xuan , Shen Qiu-Yi , Tang Hao , Cheng Li-Zhi , Yang Feng-Ping , Wei Wan-Hong , Yang Sheng-Mei
Published: September 2023

Food-grinding occurs in rodents and is influenced by multiple-factors. However, the factors affecting this behavior remain unclear. In this study, we aimed to investigate the effect of food restriction on food grinding by Brandt’s voles (Lasiopodomys brandtii), as well as the potential role of the gut microbiota in this process, through a comparison of the variations between voles with different food supplies. Food restriction reduced the relative amount of ground food to a greater extent than it lowered the relative food consumption, and altered the abundance of Staphylococcus, Aerococcus, Jeotgalicoccus, and Un--s-Clostridiaceae bacterium GM1. Strong correlations between the ground-to-consumed food ratio and the abundance of fecal microbiota were found for Un--s-Clostridiaceae bacterium GM1 and Aerococcus. The content of fecal acetate and propionate for the 7.5 g-food supply group was lower than that for the 15 g-food supply group. Further, the relative amount of ground food and ground-to-consumed food ratio were both positively correlated with the acetate content. Our study indicated that food restriction can effectively inhibit food grinding. Further, Un--s-Clostridiaceae bacterium GM1 abundance, Aerococcus abundance, and acetate content were strongly related to food grinding. Variations in gut microbial abundance and metabolite short-chain fatty acid content induced by food restriction likely promote the inhibition of food grinding. These results could potentially provide guidance for reducing food waste during laboratory rodent maintenance.
The Impact of Rural E-commerce Environment Development on Orchard Expansion from the Perspective of Tele-coupling: Case of Pinghe County in Southeast China
Authors: Liao Yajing , Wu Guirong , Huang Jinliang
Published: September 2023

This investigation delves into the profound interplay between the e-commerce environment and the agricultural system, while scrutinizing the intricate human-land coupling dynamics engen-dered by transformations within the agricultural domain. Focusing on the expansion of orchards in Pinghe County, a pivotal epicenter for Chinese sweet pomelo production, this study eluci-dates the reverberations of Rural E-commerce Environment Development on Orchard Expansion through the lens of Tele-coupling. In doing so, it unveils the nuanced tapestry of the human-land coupling associations latent within the evolutionary trajectory of the agricultural system amidst the blossoming information society. The findings underscore a symbiotic relationship between the augmentation of orchard acreage and the burgeoning rural e-commerce landscape, effec-tively propelling the economic prosperity of the agricultural system. Moreover, a tele-coupling phenomenon has emerged, underscoring the intricate web of interconnections binding the mat-uration of the rural e-commerce ecosystem with the proliferation of orchards. The research illu-minates that the transformation of land utilization, imbricated within the agricultural system, manifests as a distinctive form of tele-coupling intricately woven into the fabric of urbanization and information technology advancements. Consequently, adopting a comprehensive theoreti-cal perspective, amalgamating disparate domains across distinct geographic realms, becomes imperative for discerning the intricate nuances of the human-land coupling nexus within these multifaceted, open systems.
Sustainable Activity of Construction Companies under the Influence of Destabilizing Factors on the Duration of Implementation of Investment and Construction Projects
Authors: Lapidus Azariy abramovich , Abramov Ivan Lvovich , Kuzmina Tatyana Konstantinovna , Abramova Anastasiia , AlZaidi Zaid Ali Kadhim
Published: September 2023

Failure to meet the deadlines for the implementation of investment and construction projects is a problem in all countries of the world, and leads to unstable activity of construction companies. The article studies the most important destabilizing factors affecting the main indicator of sustainable activity of construction companies-the duration of the implementation of an investment and construction projects. To determine and assess the impact of destabilizing factors on the duration of implementation of selected investment and construction projects, a survey was conducted, in which a number of customers, consultants and contractors involved in construction projects took part. Questionnaires developed on the basis of a cluster sample were sent to respondents, 48 responses were received in response to the assessment of destabilizing factors. To analyze the received and grouped information, structural equation modeling using the Smart-PLS program was used. As a result of modeling, a number of results were obtained, the most important of which are the identification of the main reasons that lead to an average (20% - 50%) increase in the duration of projects in the construction sector. The most significant were: the lack of an appropriate procurement program for materials; inefficient scheduling by contractors and instability of construction production; poor-quality processing of incoming information and untimely deci-sion-making due to changes in projects during their implementation. Destabilizing factors con-tribute to an increase in the duration of construction sector projects, which leads to time overruns, cost overruns, and an increase in the negative impact on the overall use of resources. As a result of the study, a set of recommendations was formed, the most important of which is the use of possible compensatory measures that can allow construction companies to eliminate the risks of disrupting construction deadlines for sustainable activities. These compensatory measures include:
- recommendations to customers of the construction project;
- recommendations to contractors;
- recommendations to the consultant.
Moreover, the control of destabilizing factors that can cause delays, the improvement of contracts and the precise and clearer definition of all elements of the project can help to reduce the duration of construction, and will allow companies to maintain sustainable activities in the construction industry.
Lipid Disturbances in Breast Cancer Patients during Chemotherapy
Authors: Aliberti Aikaterini , Alikari Victoria , Tsironi Maria , Rojas-Gil Andrea Paola , Papageorgiou Dimitrios , Kolovos Petros , Panagiotou Aspasia , Panoutsopoulos George I. , Lavdaniti Maria , Zyga Sofia
Published: September 2023

Breast cancer is the most common cancer in women. Cardiovascular diseases are common complications after chemotherapy due to the effect of the drug on lipid levels. This study aimed to explore the changes in lipid profiles in patients with breast cancer under chemotherapy. Methods: In this prospective study, 50 patients with breast cancer participated. Three biochemical-lipid hematological tests were performed: total cholesterol (TC), triglycerides (TG), High-Density Lipoprotein (HDL-C), and Low-Density Lipoprotein (LDL-C) before initiation (pre-chemotherapy), at the start (1st follow-up), and at the completion (2nd follow-up) of the first cycle of chemotherapy. Statistical significance was set at p<0.05. Analyses were conducted using SPSS Statistical Software (version 22.0). Results: Mean TC values increased significantly at 2nd follow-up. TG values decreased significantly from 1st to 2nd follow-up. HDL-C was significantly lower at 1st follow-up compared to pre-chemotherapy and 2nd follow-up reaching similar to the initial levels. LDL-C values were significantly higher at 2nd follow-up compared to pre-chemotherapy measurement. Significantly positive correlations of BMI with pre-chemotherapy LDL-C, 1st follow-up TC, 1st follow-up LDL-C, 2nd follow-up TC, and 2nd follow-up LDL-C were found. Conclusions: There is a statistically significant increase in the levels of TC and LDL-C in breast cancer patients during chemotherapy. This study was not registered.
Multiple Positive Solutions for a Coupled System of Fractional Order BVP with p-Laplacian Operators and Parameters
Authors: Ahmadini Abdullah Ali H. , Khuddush Mahammad , Nageswara Rao Sabbavarapu
Published: September 2023

In this study, we investigate the existence of positive solutions within a system of Riemann-Liouville fractional differential equations that incorporate the (r1,r2,r3)-Laplacian operator while being subject to three-point boundary conditions. These equations incorporate various fractional derivatives and are influenced by parameters represented as (ψ1,ψ2,ψ3). Our approach involves employing techniques such as cone expansion and compression of the functional type, in conjunction with the Leggett-Williams fixed point theorem, to establish the existence of positive solutions. To emphasize the practical significance of our findings in the realm of fractional differential equations, we provide two illustrative examples.
Processing Speed throughout Primary School Education: Evidence from a Cross-country Longitudinal Study
Authors: Tikhomirova Tatiana , Kuzmina Yulia , Malykh Artem , Malykh Sergey
Published: September 2023

This cross-country four-year longitudinal study investigated the development of processing speed throughout primary school education. The analyses were conducted on data collected from 441 schoolchildren in Grades 1, 2, 3 and 4 (aged 6.42 to 11.85 years) in the Kyrgyzstan and Russia. Mixed effects growth modeling was applied to estimate average and individual growth trajectories for processing speed at two cross-country samples. Latent class growth modeling was conducted to identify different types of growth trajectories for processing speed and to compare the distribution of the types within the analyzed samples. According to the results, processing speed significantly increases across primary school years. The trajectory is characterized by nonlinear changes with more intensive growth between Grades 1 and 2, which later slows down until Grade 4. There were no significant cross-country differences in the initial score of processing speed or developmental changes in processing speed across primary school years. The development of processing speed is described by a model with three quadratic growth types but minimally differs. It is concluded that in both samples, the development of processing speed may be characterized by homogeneity, with the most intensive growth from Grade 1 to Grade 2 and subsequent linear improvement until Grade 4.
Molecular Characterization of Two Totiviruses from the Commensal Yeast Geotrichum candidum
Authors: Khalifa Mahmoud E. , MacDiarmid Robin Marion
Published: September 2023

Mycoviruses are widespread across the major taxa of fungi including yeasts. Mycoviruses in the yeast fungus Geotrichum candidum are not well studied with three G. candidum-associated viral species characterized to date, all of which belong to the Totiviridae genus Totivirus. In this study, we report the molecular characteristics of another two totiviruses co-infecting isolate Gc6 of G. candidum. The two totiviruses were tentatively named Geotrichum candidum totivirus 2 (GcTV2-Gc6) and GcTV4-Gc6). Both viruses have typical genome organization of totiviruses comprising two ORFs encoding capsid protein (CP) and RNA-dependent RNA polymerase (RdRp) at the N and C termini, respectively. Genomes of GcTV2-Gc6 and GcTV4-Gc6 are 4592 and 4530 bp long, respectively. Both viruses contain the -1 frameshifting elements and their proteins could be expressed as a single fusion protein. GcTV2-Gc6 is closely related to a totivirus isolated from the same host whereas GcTV4-Gc6 is related to insect-associated totiviruses. The phylogenetic analysis indicated that GcTV2-Gc6 and GcTV4-Gc6 belong to two different sister clades, I-A and I-B, respectively. It is interesting that all viruses identified from G. candidum belong to the genus Totivirus. It is possible that the RNA interference (RNAi) mechanism is not active to suppress totivirus accumulation in isolate Gc6.
Saliva for Diabetes’ Complications: Non-Invasive Diagnostics and Monitoring
Authors: Esteves Eduardo , Mendes Vera , Manadas Bruno , Lemos António , Alves Dora , Bernardino Liliana , Correia Maria José , Barros Marlene , Esteves Ana Cristina , Rosa Nuno
Published: September 2023

Type 2 Diabetes Mellitus is a chronic metabolic disease that poses a significant long-term health risk due to its debilitating complications. While the diagnosis and monitoring of diabetes are well-established, the monitoring of its numerous complications presents a challenge, which can compromise patients' prognosis and quality of life. We analyzed the proteome of ten saliva samples, five from healthy individuals and five from patients with Type 2 Diabetes Mellitus. The aim was to identify potential biomarkers of Type 2 Diabetes Mellitus and its complications. We used PANTHER and FUNRICH tools to conduct a functional analysis and enrichment approach. Our findings revealed 622 proteins involved in 16 disrupted biological processes, which are linked to Type 2 Diabetes Mellitus. Metabolic processes, response to stimuli, processes of the immune system, and signaling are notable due to their known relation with Type 2 Diabetes Mellitus. Enrichment analysis has revealed that there are eleven biological processes that have been deregulated. These processes involve twenty different salivary proteins that are associated with multiple complications in diabetes. Our findings demonstrate that saliva is a dependable source of possible biomarkers that can be used to monitor diabetes and its complications.
Recent Advancements in Genome-Targeting Nucleic Acids and Their Potential for Therapeutic Applications
Authors: Mikame Yu , Yamayoshi Asako
Published: September 2023

Recent developments in artificial nucleic acid and drug delivery systems (DDS) present possibilities for the symbiotic engineering of oligonucleotide therapeutics, such as antisense oligonucleotides (ASOs), and small interfering RNA (siRNA). These technologies can also be applied for triplex-forming oligonucleotides (TFOs) to develop symbiotic genome-targeting tools and a new class of oligonucleotide drugs. Many reports have described the functionalization of TFOs and the enhancement of TFO activities. In particular, the tethering of crosslinking groups to TFOs enables irreversible triplex formation and is frequently exploited for antigene and genome-editing experiments. These crosslinkable TFOs have shown considerable potential for therapeutic application. In this review, we revisit these crosslinking techniques and explore the combination of these techniques with recent artificial oligonucleotide and DDS technologies.
Enrichment of Artemia sp. with autochthonous probiotics at different levels in larviculture of piauçu Megaleporinus macrocephalus
Authors: Barros Francisco Alex Lima , Dias Joel Artur Rodrigues , Abe Higo Andrade , Costa Júnior Keber Santos , Sousa Natalino da Costa , Cordeiro Carlos Alberto Martins , Fujimoto Rodrigo Yudi
Published: September 2023

The research investigated the effect of dietary supplementation with Artemia sp. enriched with the autochthonous probiotic Enterococcus faecium on growth performance, microbiota modulation, intestinal morphology, and resistance to pathogenic bacteria of Megaleporinus macrocephalus larvae. The study evaluated four treatments (C: without probiotics; T1: 1 × 104 ; T2:1× 106 ; and T3: 1 × 108 CFU·mL-1) in quadruplicates. The larvae (n = 160; weight = 5.3 ± 2.3mg and length = 3.73±0.4mm) were distributed in 16 L containers at a density of 10 larvae·L-1 for 20 days. The productive performance, survival, gut microbiology, and histology were measured. The larvae were also submitted to acute challenge against the pathogenic bacterium Aeromonas hydrophila. The results showed that supplementation with 1 × 108 CFU·mL-1 promotes greater gain in length (13.78 ± 0.40 cm) and total weight (0.08 ± 0.002 g), higher counts of lactic acid bacteria and lower total heterotrophic in the intestines (7.11±0.30; 0.12 ± 0.09 log CFU·g-1, respectively) and larger villi (0.26 ± 0.03μm). Diets containing probiotics influenced the animals’ resistance to acute infection, with a lower accumulated mortality in T3 (33% ± 11.54%) and a higher one in C+ (93% ± 11.54%). Thus, probiotic supplementation with the autochthonous bacterium E. faecium (1×108CFU·mL-1) provides zootechnical improvement, villus increase and greater resistance to infections.
Keefektifan Pelaksanaan Teaching Factory pada Kompetensi Keahlian Teknik Pemesinan di SMK Warga Surakarta
Authors: Lupi Nisa Palupi
Published: September 2023

Penelitian ini bertujuan untuk memperoleh gambaran tentang prosedur pelaksanaan keefektifan pelaksanaan teaching factory pada kompetensi keahlian teknik pemesinan di SMK Warga Surakarta selama ini dan memperoleh gambaran sejauhmana keefektifan pelaksanaan teaching factory pada kompetensi keahlian teknik pemesinan di SMK Warga Surakarta selama ini.

Penelitian ini merupakan penelitian evaluatif dengan model evaluasi CIPP. Desain penelitiannya adalah deskriptif kualitatif dan kuantitatif. Sumber data penelitian ini meliputi informan yaitu pimpinan, manajemen sekolah, dan PIC TEFA dan responden yaitu siswa-siswa. Teknik pengumpulan datanya yaitu observasi, wawancara, dan angket. Validitas data untuk data kualitatif menggunakan triangulasi metode. Sedangkan untuk data kuantitatif validitas instrumennya menggunakan validitas isi (expert judgement). Analisis data untuk data kualitatif menggunakan teknik analisis data menurut Miles & Huberman sedangkan untuk analisis data kuantitatifnya menggunakan kriteria penilaian Saifudin Azwar.

Hasil penelitian ini menunjukkan bahwa Context; Pelaksanaan teaching factory mampu mewujudkan visi dan misi sekolah. Input; Sekolah telah menyediakan peralatan, ruang, dan tenaga pengajar yang memadai. Pencatatan harian sudah ada, namun tidak ada guru yang bertanggung jawab secara penuh. Struktur organisasi sudah ada, namun pelaksanaan jobdesk belum maksimal. Process; Praktik berbasis corporate culture, namun siswa belum melakukan semua tahapan dalam teaching factory. MRC belum termanajemen dan terjadwal. Kegiatan promosi belum maksimal. Praktik secara team work dengan bahan baku proses produksi. Guru menyelesaikan pekerjaan produksi dari pelanggan yang belum terselesaikan oleh siswa. Product; Pelaksanaaan teaching factory mampu meningkatkan kompetensi siswa. Produk yang dihasilkan mampu bersaing di pasar dan digunakan untuk kebutuhan internal sekolah. Berdasarkan analisis data menunjukkan keefektifan pelaksanaaan teaching factory di SMK Warga Surakarta telah memenuhi indikator teaching factory level 4 efficiency.
ANALISIS POTENSI ANGIN DI KECAMATAN JATEN KABUPATEN KARANGANYAR BERBASIS INTERNET OF THINGS (IoT)
Authors: Adiputra Reynaldi Fajar
Published: September 2023

Penelitian ini bertujuan untuk mengidentifikasi rekomendasi turbin angin yang sesuai untuk pengukuran berdasarkan potensi angin di Kabupaten Jaten. Penelitian ini menggunakan metode eksperimen. Sumber data untuk penelitian ini meliputi pengukuran kecepatan dan arah angin yang diperoleh menggunakan mikrokontroler berbasis IoT. Purposive sampling digunakan untuk mengumpulkan sampel. Alat yang digunakan untuk pengambilan data terdiri dari anemometer untuk mengukur kecepatan angin dan wind vane untuk menentukan arah angin. Data dianalisis secara deskriptif dan kuantitatif. Hasil kajian menunjukkan kecepatan angin rata-rata tertinggi teramati pada ketinggian 10 meter Di Kabupaten Jaten kecepatan angin rata-rata 0,47 m/s, dengan kecepatan tertinggi 3,38 m/s. Arah angin dominan bertiup dari Tenggara ke Barat. Potensi angin di daerah ini tidak cukup tinggi untuk dimanfaatkan secara efektif sebagai sumber energi angin yang signifikan karena besarnya yang rendah. Dalam konteks Kabupaten Jaten, kincir angin Savonius vertikal direkomendasikan untuk memanfaatkan kecepatan angin rendah. Jenis turbin Savonius yang dapat digunakan seperti turbin Savonius tipe Helical 2 bilah dengan end plate memiliki kecepatan potong 1,906 m/s dan turbin Savonius tipe S 2 bilah dengan penambahan 4 sirip memiliki kecepatan potong 1,8 m/s.
STUDI EKSPERIMENTAL BERBAGAI JENIS PROSES PENGEROLAN TERHADAP OVALISASI PIPA BAJA BERDIAMETER KECIL
Authors: Adnya Zefania Mustika
Published: September 2023

Pipa baja digunakan secara luas di dalam industri, dan proses pengerolan manual merupakan salah satu metode yang umum digunakan untuk memproduksi dan membentuk pipa-pipa tersebut sesuai pemintaan. Namun, proses pengerolan meyebabkan pipa baja terdeformasi atau disebut dengan ovalisasi. Ovalisasi pipa selama proses pengerolan manual dapat menyebabkan penurunan kekuatan struktural dan kualitas pipa. Penelitian ini bertujuan untuk menguji pengaruh pengisian pasir, hot rolling, dan kombinasi pasir dan hot rolling terhadap ovalisasi pipa baja berdiameter kecil pada proses pengerolan manual. Penelitian dilakukan menggunakan metode eksperimental, dengan empat perlakuan: pengerolan standar,  pengerolan dengan pengisian pasir, pegerolan dengan hot rolling, dan pengerolan dengan kombinasi pengisian pasir dan hot rolling. Pada tahap persiapan spesimen dilakukan pengukuran ketebalan dan panjang pipa baja hingga menghasilkan 8 spesimen uji. Kemudian, pipa-pipa tersebut diisi dengan pasir pada bagian dalamnya sesuai dengan variasi yang ditentukan. Pada tahap pengukuran, diameter spesimen setelah proses pengerolan diukur dengan akurasi menggunakan jangka sorong. Hasil pengukuran nilai ovalisasi tertinggi sebesar 0,36% terjadi pada proses pengerolan standar dengan ketebalan pipa baja 2mm. Sedangkan, nilai ovalisasi pipa baja terendah sebesar 0,05% terjadi pada proses pengerolan dengan pengisian pasir dan hot rolling. Analisis data menggunakan metode analsis deskriptif. Hasil penelitian ditemukan bahwa terdapat perbedaan nilai ovalisasi pada 4 jenis proses sehingga menghasilkan metode terbaik yaitu pengerolan dengan pengisian pasir dan hot rolling.

Kata Kunci : Pipa baja, Ovalisasi, proses pengerolan
THE MANAGEMENT OF DELIVERY PAIN: A BIBLIOMETRIC ANALYSIS
Authors: Wahyuningsih Istiqomah Risa , Putri Nabila Anlinna , Sariayu Mita Diana , Lukiana Avisia , Putri Firdhausi Mariska
Published: September 2023

Introduction: Management of delivery pain was part of the most important tasks that health workers need to focus on. Non-pharmacological and pharmacological approaches have been shown to provide significant benefits in managing delivery pain and ensuring the well-being of the mother and her baby. This study analyses research trends on management of delivery pain.

Methods: The documents from 2013 to 2022 (December 31, 2022) were searched, in English, Article and Review. The implementation date of the strategy is April 11, 2023 and search terms and strategies are as follows “delivery” OR “pain management” AND “Articles and Reviews” AND “English”. Visualization and analysis of research trends from downloaded article data in CSV format using VOSviewer 1.6.18.

Results: To achieve this goal, a bibliometric analysis was conducted on 469 articles obtained from the Scopus database, which identified the most productive countries/regions, journals, authors, and potential future topics of this research field. According to this study, 2017 saw the most significant growth; the United States was the most productive country in this field; BMC Pregnancy and Childbirth was the most prestigious journal in this field; Khildea, S., contributed the most significant research in this field. The use of complementary therapies, drug administration and maternal care requires further study in the future.

Conclusion: The conclusion of this study was that pain management continues to grow in research across different countries, fields and expertise. The future needs to focus on the use of complementary therapies, drug delivery pathways and maternal care for further research.

 
Salient stakeholder involvement model using temporary and continuous financial approaches in globalization
Authors:   Islam Batik University, Maryam Siti
Published: September 2023

The current globalization in fashion trends that enter Indonesia threatens the sustainability of Batik products in Indonesia. Efforts to maintain the financial sustainability of batik so far involve the role of salient stakeholders. However, stakeholder involvement in preserving Surakarta batik has not been fully patterned. This research reviews stakeholders’ efforts to develop Batik in Surakarta and how stakeholders empower the community to develop and financially sustain batik. The research method used qualitative descriptive with phenomenological design. The informants are batik stakeholder in Surakarta which includes Kraton Kasunanan, Pura Mangkunegaran, Surakarta Tourism Office, SMA Batik Surakarta, dan Kampoeng Batik Laweyan Development Forum (FPKBL). Data was collected with in-depth interviews, observations, and documentation. Data analysis activities include data reduction, data display, and inference. The results showed that Batik investors involve salient stakeholders to maintain the Batik industry. Each stakeholder uses a varied approach to influence the community. The stakeholder approach in supporting the preservation of Surakarta batik is classified as a temporary and sustainable approach. This study shows that salient stakeholders have a significant role in maintaining and improving the sustainability of Batik Surakarta.
The effect of digital marketing and sales information systems on customer’s purchase intention for increasing the sales rate of digital shopping
Authors:   Ajman University, Mohamed Khaled M. , Wong Wing-Keung ,   Asia University, Pan Shin-Hung ,   Chaoyang University of Technology
Published: September 2023

Today, with the development of technology, digital sales have become an important part of companies’ sales. In such an atmosphere, the development of marketing and sales information systems can help to improve marketing and sales in the field of digital markets. Paying attention to information system and combining it with marketing in the digital space can lead to an understanding of how information system and costumer behavior contributes to the purchase decision of a company’s customers. In this regard, the current research has been carried out with the aim of discovering the model of the effect of information system on the consumer’s purchase intention in the digital platform. In order to achieve the mentioned goal, firstly, based on the in-depth review of the subject literature, the conceptual model of the research has been developed. For the purchase intention, variables such as choosing a brand, intermediary or place of purchase, purchase amount, purchase time and payment method have been identified. Then, to measure the relationship between research variables, a research questionnaire was prepared and distributed among 250 customers who could be accessed. In this research, rank regression analysis method was used to analyze the data from the questionnaire. The results of this research show that information system and digital marketing directly affects the customer’s purchase intention, also it is effective on the sales rate of digital shopping.
Satisfaction’s model and work efficiency for sustainable development in food industry
Authors:   University IBBI, Maria Elvie , Wardana Wikrama ,   Universitas Pramita Indonesia, Lenggogeni  ,   National Research and Innovation Agency, Nuraeni  ,   Muhammadiyah University, Cahyati Peni ,   Tasikmalaya Health Polytechnic, Astuti Rini ,   Winaya Mukti University
Published: September 2023

Within the confines of South Jakarta’s food and beverage industry, this research endeavors to examine and comprehend the following topics: 1) organizational learning; 2) job motivation; 3) job satisfaction; 4) employee performance; 5) sustainable development, and 6) the effects of organizational learning and job motivation on job satisfaction, as well as their effects on employee performance for sustainable development. Both descriptive and explanatory surveys were utilized in this inquiry, and its focus is on employees within these organizations, with a sampling of 30 individuals. The investigation has a causal nature, and this study is done within a cross-sectional timeframe. In South Jakarta, food and beverage company employees have demonstrated satisfactory levels of learning and job motivation, as evidenced by research findings. Their work enthusiasm is also generally commendable, and they express contentment with their employers. However, the impact of satisfaction on employee performance cannot be discounted. Overall, it seems that organizational learning and job motivation play key roles in determining job satisfaction and performance in the food and beverage industry of South Jakarta. In South Jakarta’s food and beverage sector, employee satisfaction has a notable impact on their performance. As such, maintaining employee satisfaction is crucial for companies operating in the area. A crucial determinant of job satisfaction is work motivation, which must remain high. Thus, South Jakarta’s food and beverage companies must maintain these factors to ensure that their employees remain satisfied and productive for sustainable development.