bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of Renutrition Milk on the Improvement of Clinical Profile and Gut Microbiota of Malnourished Children
Authors:   Laboratory of Bioconversion, Engineering Microbiological and Safety Health, Faculty of Natural and Life Sciences, University of Mustapha Stambouli of Mascara, Mascara,29000,Algeria, Belgharbi Asmaa , Meddah Aicha ,   Laboratory of Bioconversion, Engineering Microbiological and Safety Health, Faculty of Natural and Life Sciences, University of Mustapha Stambouli of Mascara, Mascara,29000,Algeria, Meddah Boumediene ,   Laboratory of Bioconversion, Engineering Microbiological and Safety Health, Faculty of Natural and Life Sciences, University of Mustapha Stambouli of Mascara, Mascara,29000,Algeria, Mullié Catherine ,   Laboratory of Glycochemical, Antimicrobiensand Agro-resources, Amiens, 80080,France, Nehhal Mokhtar ,   Service of pediatric, EPH Meslem Tayeb, Mascara, 29000,Algeria
Published: March 2021

Childhood malnutrition is a severe disease that kills 3.1 million children under the age of five worldwide yearly. Our objectives are to comparethe clinical profile and the intestinal microbiota of malnourished children and healthy ones residing in the city of Mascara (Algeria), and to specify the impact of the administration of renutrition milk on the improvement of their gut microbiota.40 children in total, aged between 2 and 36 months were chosen for this study. A clinical examination and a microbiological analysis of fecal matter were performed. The first results showed that the malnourished children included in the study suffer from severe malnutrition characterized by stunting and remarkable underweight and that their intestinal flora is quantitatively and qualitatively differentfrom that of healthy children. Moreover;the administration of the renutrition milk has a positive influence on the composition of the intestinal flora in these malnourished children.
Palavras originárias e pensamentos visíveis: ambivalência, imagem, criação
Authors: Rezende Diego
Published: March 2021

Investigação que tem como objetivo analisar e aprimorar os processos de criação em torno das excitações intelectuais provocadas pela “ambivalência”. Em um primeiro momento, examinaremos o desenvolvimento do conceito de “ambivalência” nos textos psicanalíticos de Sigmund Freud. Para isso, abordaremos seus trabalhos sobre a noção de “inconsciente” e sobre o significado de “palavras originárias”. Em um segundo momento, analisaremos imagens criadas por René Magritte no intuito de explorarmos a “ambivalência” presente em seus “pensamentos visíveis”. E, em um terceiro e último momento, articulando os tópicos anteriores, esboçaremos a possibilidade de delimitarmos uma “poética visual da ambivalência”. AbstractResearch that seeks to analyze and improve the creative processes around the intellectual excitations caused by “ambivalence”. At first, we will examinethe development of the concept of “ambivalence” in Sigmund Freud’s psychoanalytic texts. For this, we will approach your work on the notion of “unconscious”and on the meaning of “original words”. In a second step, we will analyze images created by René Magritte in order to explore the “ambivalence” present in his “visible thoughts”. And, in a third and last moment, articulating the previous topics, we will outline the possibility of delimiting a “visual poetics of ambivalence”.
Arte e resistência micropolítica: o museu-clínica como exercício de hospitalidade
Authors: Proença Luiza
Published: March 2021

Em torno da ideia de hospitalidade, o ensaio investiga a possibilidade de políticas no campo da arte que se desloquem dos hábitos acomodados de assimilação de diferenças em direção a dinâmicas mais atentas às vidas que pulsam dentro e fora das instituições artísticas, como forma de resistência à cultura de hostilidade e repressão. Este deslocamento é pensado com a ajuda da documentação do Congresso de Psicodrama realizado no Museu de Arte de São Paulo, em 1970, um evento que esboçou o museu-clínica, sugerindo a instauração de processos simultaneamente clínicos, políticos, éticos e estéticos e de análise institucional.  AbstractFrom the idea of hospitality, the essay investigates the possibility of politics in the art field that could move from the accommodated habits of assimilation towards dynamics more attentive to the lives that pulsate inside and outside art institutions, as a form of resistance to the culture of hostility and repression. This movement is thought through the documentation of the Psychodrama Congress held at the São Paulo Art Museum, in 1970, an event that outlined the museum-clinic, suggesting the establishment of processes of institutional analysis and  that involves, simultaneously, a clinical, political, ethical, and aesthetic dimension.
Os materiais aparentemente não mais utilitários são os únicos que de alguma forma são úteis
Authors: Furtado Manoela
Published: March 2021

Manoela recolhe objetos descartados que encontra em seus trajetos pela cidade e propõe novas condições de funcionamento a essas mercadorias sucateadas. Ao deter-se sob materiais que estão à margem de uma sociedade calcada na economia de trocas comerciais - que foram fatalmente direcionados ao lixo por perderem sua serventia -, os estabelece como sobras desvalorizadas que tem potencial estético. Assim, subverte a lógica normatizante ao criar modos insurgentes de existência baseadas no contato e no afeto do que é considerado ordinário. Abstract Manoela collects discarded objects she finds in her paths about town and proposes new working conditions to these scrapped goods. By focusing on materials - fatally led to being discarded for losing their usefulness -  that are on the sidelines of a society based on commercial transactions, stabilishes them as devalued scraps with aesthetic potential. Thus, she subverts the normalizing logic in creating insurgent ways of existence based on connection and affection to what is considered ordinary.
The Utility of Novel Fish-Skin Derived Acellular Dermal Matrix (Kerecis) as a Wound Dressing Material
Authors: Kim Tae Hyung , Park Jun Ho , Jeong Hyun Gyo , Wee Syeo Young
Published: March 2021

Background: The newly-approved Kerecis is a piscine acellular dermal xenograft. This piscine acellular dermal matrix (ADM) has specific bioactive lipid mediators, omega-3 polyunsaturated fatty acids, and has a positive effect on the process of wound healing. This study aimed to explore the utility of this novel material by comparing healing rates, and suggest the proper timing for applying Kerecis.
Methods: Patients who visited the hospital with acute or chronic deep dermal wounds from June 2019 to May 2020 were enrolled in the study. A total of 48 patients were assessed. All wounds in the experimental group (n=16) were treated only once with Kerecis and a non-adherent absorptive foam material (Therasorb) to cover the ADM. In the control group, daily conventional dressings were provided. All wounds sizes were measured with mass-market computer software in a method suggested by the authors for the first time.
Results: The mean healing rate proved to be faster in the Kerecis group (P<0.05) versus the control group, and no complications were observed. It was statistically proved that treating burn wounds with the ADM showed better healing rates than the conventional method (P<0.05).
Conclusion: This study establishes that managing wounds with the ADM is likely to heal wounds faster than traditional dressings. In addition, for burn wounds, a prolonged application (10 days vs. 5 days after the onset) showed a better wound healing rate (98.8%±2.5% vs. 67.0%±14.3%, respectively, P=0.029).
Using Acellular Dermal Matrix to Treat Repetitive Tendon Rupture after Excision of Ruptured Intratendinous Ganglion
Authors: Sohn Sung-Min , Hwang Na-Hyun , Chung Jae-Ho , Park Seung-Ha , Yoon Eul-Sik
Published: March 2021

Existing literature has not explored repeated tendon ruptures caused by torn intratendinous ganglions. The treatment of intratendinous ganglion of the hand remains a challenge, as it is difficult to completely excise the ganglion while also preserving the tendon. Herein is a report on a case of ruptured intratendinous ganglion in the extensor digitorum communis which resulted in repeated tendon reconstruction surgeries. The authors incorporated an acellular dermal matrix with tendon transfer, demonstrating great clinical improvement and successful repair thus far.
Modified Medial Gastrocnemius Myocutaneous Flap Technique for Knee Joint Coverage after Total Knee Arthroplasty
Authors: Kim Dongseok , Kim Junhyung , Jeong Woonhyeok , Jo Taehee , Choi Jaehoon
Published: March 2021

While there are many reasons the medial gastrocnemius flap is often the favored treatment for soft tissue defects around the knee area, this flap has some disadvantages. Reduced volume at the distal part of the flap and a short reach complicate provision of sufficient coverage for soft tissue defects superior to the patella and the lateral knee. In order to overcome these shortcomings, we modified the typical surgical technique by combining a medial gastrocnemius muscle flap and a medial sural artery perforator flap. This approach was applied to four patients who had developed deep infections and skin and soft tissue defects around the knee joint after total knee arthroplasty. The surgeries were successful. Dead space was well-filled and wounds healed without complications in all patients. This modified medial gastrocnemius myocutaneous flap provides a new option for treating challenging skin and soft tissue defects caused by deep infection after total knee arthroplasty.
Adjuvant Role of Botulinum Toxin A in the Management of Wounds Accompanied by Parotid Gland or Duct Injuries
Authors: Jeong Yeonjin , Lee Sang-Yeul , Sung Kun-Yong
Published: March 2021

Background: Parotid gland or duct injuries may occur after facial trauma or surgical procedures around the parotid gland. Such injuries often cause saliva to leak into the wound, and as a result, the autolytic enzymes in the saliva can delay wound healing. To promote wound healing in such cases, salivary leakage must be stopped until the wound has completely healed. Though there are several known measures for preventing salivary leakage, including compressive dressings, suction drainage, food restriction, and anticholinergic drugs, they often yield unsatisfactory results. This study aimed to evaluate the clinical efficacy of botulinum toxin A in stopping salivary secretions and inducing wound healing in wounds accompanied by parotid gland or duct injuries.
Methods: A retrospective study was conducted to evaluate the efficacy of botulinum toxin A for treating salivary leakage due to parotid gland or duct injuries. Five patients were treated between 2011 and 2016, three of whom received postoperative injections with a total dose of 30–40 units of botulinum toxin A. One of the other two patients was injected with the same amount of botulinum toxin A preoperatively, and the other received an intraoperative injection.
Results: All five patients showed an abrupt decrease of salivary leakage on the 3rd day after toxin injection and satisfactory wound healing without untoward side effects.
Conclusion: This study demonstrates the critical role played by botulinum toxin A in management of wounds complicated by abnormal leakage of saliva, when the parotid gland or duct is injured.
Fatores associados aos transtornos depressivos em estudantes universitários da área de saúde: uma revisão integrativa
Authors: Vieira Santos Silva Thais , De Santana Correia Luana , De Mattos Oliveira Larissa
Published: March 2021

A depressão é um transtorno psíquico que se apresenta como uma das principais causas de incapacitação em mais de 300 milhões de pessoas no mundo. Entre essa população, os estudantes da área da saúde têm apresentado cada vez mais transtornos depressivos, o que pode acarretar em prejuízos no desempenho acadêmico e nos relacionamentos interpessoais. Por esse motivo, a saúde mental dos estudantes universitários tem sido foco da atenção de especialistas, visto que estudantes da área de saúde nem sempre recebem informações suficientes sobre saúde mental e se expõem frequentemente a situações de estresse, levando-os ao adoecimento psíquico e dificuldades no atendimento aos pacientes. O objetivo desse estudo foi investigar, por meio de uma revisão integrativa, os fatores descritos na literatura associados aos transtornos depressivos em estudantes da área de saúde. Os estudos analisados mostram uma associação da má qualidade do sono, falta de lazer e atividade física, alimentação inadequada, influência familiar, uso de substâncias ilícitas, dificuldades financeiras, o fato de ser mulher e aspectos acadêmicos, como fatores predisponentes para a depressão entre essa população.
ANALYSE D'UNE PRODUCTION ÉCRITE ET ORALE: SENS EN CONTEXTE ÉNONCIATIF DU FRANÇAIS LANGUE ÉTRANGÈRE
Authors: Kohwer Rudy
Published: March 2021

RÉSUMÉ: Dire aujourd’hui que la faute de syntaxe et la confusion lexicale soient inexistantes dans les énoncés écrits et parlés d’apprenants du Français Langue Seconde (FLS), est erroné. Ce n’est donc pas les apports théoriques de la linguistique structurale et de la psychologie béhavioriste des années 1950 qui corrigent selon une pédagogie d’enseignement pourtant déjà fondée sur l’abordage par compétences de communication. Si nous partageons par experience certains manques dans la méthode de français Latitudes 1 (2008) à appliquer par le manuel du professeur, c’est que tout s’oppose à enseigner le mode de combinaison ensemble avec l’interprétation des objets pour l’apprentissage des structures syntaxiques des énoncés et leur interprétation à l’orale. Et cela malgré la fréquence d’activités de répétition d’expressions simples en contexte déterminé par les trois actes de language inviter et répondre à une invitation, demander et indiquer l’heure et, prendre et fixer un rendez-vous, lesquels contextualisent une tâche finale soumise à analyse. Afin de mieux appréhender les règles pour des structures syntaxiques et des représentations de signifié bien formées dans les énoncés d’apprenants, il nous paraît pertinent de développer par l’approche analytique et contemporaine de la philosophie du langage. Après une partie consacrée à la présentation du corpus de référence et en rendant compte de la complexité du problème de recherche, nous analyserons une production langagière d’apprenante par les outils desdites approches imposés sur l’objet d’étude suivant : les descriptions syntaxiques et les représentations de signifié.
OS DESNUDES MEMORIALÍSTICOS DOS HOMO-BIOS DE SILVIANO SANTIAGO E DE VIRGINIA WOOLF
Authors: Medeiros Pedro Henrique Alves de , Nolasco Edgar Cézar
Published: March 2021

Este trabalho tem por objetivo realizar uma leitura comparatista, biográfica e fronteiriça entre as obras Mil rosas roubadas (2014) do escritor brasileiro Silviano Santiago e Orlando: uma biografia (2017) da inglesa Virginia Woolf. Para isso, utilizaremos uma metodologia de caráter bibliográfico pautada na epistemologia crítica biográfica fronteiriça com o intuito de discutirmos as semelhanças e as diferenças homo-biográficas entre os autores e os livros citados ao passo que, simultaneamente, promoveremos desnudes de suas personae literárias, metafóricas e empíricas atravessadas pelos espaços (auto)biográficos que lhes cornecem. Dentre os conceitos utilizados para o ensejo mencionado, valeremo-nos da memória, aliados hospitaleiros, exterioridade, homo-biografia e amizade corroborados, dentre outros, pelos intelectuais Leonor Arfuch, Eneida Maria de Souza, Juliano Garcia Pessanha, Walter Mignolo, Jacques Derrida e Francisco Ortega. Portanto, respaldados pelo exposto, buscaremos delinear grafias comparatistas entre Silviano e Virginia no que concerne as suas existências outras enquanto escritores homossexuais que escre(vi)vem, ou escre(vi)veram, assentandos em modus operandi e vivendi passíveis de os aproximarem não só no plano de suas semelhanças homo-biográficas e literárias, mas, sobremaneira, das diferenças que os separam aproximando-os.
DINAMIZANDO O ENSINO DE INGLÊS EM TEMPOS DE PANDEMIA: EXPERIÊNCIAS DE ENSINO ATRAVÉS DO INSTAGRAM DE UM PROJETO DE EXTENSÃO
Authors: Martins Suellen Thomaz de Aquino
Published: March 2021

Este trabalho apresenta a proposta do UESC English in quarantine, ação do projeto de extensão “Dinamizando o Ensino de Língua Inglesa” da Universidade Estadual de Santa Cruz (UESC), que aborda o ensino de inglês e promove oportunidades de aprendizagem por meio das redes sociais durante a pandemia. Baseando-se no referencial teórico de Costa (et al., 2015), Gohn (1999), Nunan (1989), Walsh (2005), Atkinson (1987), Stibbard (1998) e Ardichvili (2008), discutem-se as experiências de ensino na rede social e desenvolve-se uma compreensão inicial dos desafios e potencialidades envolvidos neste processo. Metodologicamente a ação acontece, exclusivamente, através do Instagram, por meio de atividades que oportunizam interações na língua-alvo, pela utilização de diversas ferramentas disponibilizadas nessa plataforma digital. Mediante o desenvolvimento das atividades, constataram-se as potencialidades de uso do Instagram para o ensino de inglês promovendo a interação na língua-alvo com os seguidores-participantes, além de evidências de construção de uma comunidade de aprendizagem colaborativa utilizando-se essa plataforma.
A HORA DA ESCRITA: CLARICE LISPECTOR, LINGUAGEM E METAFICÇÃO
Authors: Santos Raimunda Maria , Resende Joelma de Araújo Silva , Lopes Sebastião Alves Teixeira
Published: March 2021

O objetivo do presente artigo é examinar a narrativa A hora da estrela, observando o fazer literário de Clarice Lispector. A autora transforma a linguagem em elemento estético, apostando no intimismo e na reflexão constante sobre os limites e falibilidade da palavra, sobre a impossibilidade de dizer. Para ressaltar a força estética da linguagem de Clarice, recorre-se, dentre outros, aos conceitos de (auto)ficção e metaficção. Trata-se de uma prática narratológica que transforma a própria existência e labor em matéria literária, demonstrando a angústia de viver e escrever, ao passo que, metaficcionalmente, coloca a linguagem em escrutinação. Em forma de conclusão, apontamos como a autora continua a desafiar e seduzir uma legião de leitores por, de forma metaficcional narcisista, apostar na complexidade da linguagem.
NONSENSE E REPRESENTAÇÃO: ALICE E A RELAÇÃO COM O REAL
Authors: Pereira Marucci Isabella , Giroldo Ramiro
Published: March 2021

O presente artigo tem como objetivo a análise da relação entre o nonsense literário e o real nas obras Alice no País das Maravilhas e Através do Espelho e o que Alice encontrou por lá, ambas de Lewis Carroll. Busca-se compreender como configura uma representação da realidade ou daquilo que tomamos por real. Atribuindo-lhe assim, significado e reflexão acerca do conceito que, primariamente, remete a algo que “não possui sentido”. O caminho que se pretende percorrer no trabalho começa com uma observação sobre a ocorrência do nonsense em Alice, aliando a teoria específica sobre; passando adiante para as concepções de representação. Para tanto, serão tomadas noções de representação em Adorno, Aristóteles, Benjamim, Auerbach, Barthes e considerações acerca do nonsense trabalhadas por Anthony Burgess.
ELEIÇÃO PRESIDENCIAL DE 2018: O FUNCIONAMENTO DO LUGAR DISCURSIVO DO PORTA-VOZ NA CAMPANHA DE TRÊS CANDIDATOS
Authors: Rocha de Oliveira Beatriz , Gomes da Silva Edvania
Published: March 2021

Neste artigo, objetivamos analisar como se constituem as diferentes posições-sujeito ocupadas por três candidatos à presidência do Brasil nas eleições de 2018, que se filiam, em alguma medida, à esfera religiosa, indicando quais memórias tais posições retomam. Como hipótese, defendemos que funciona, nesse caso, o lugar discursivo do porta-voz e, por isso, buscamos identificar, a partir das posições por meio das quais os referidos sujeitos políticos se subjetivam como candidatos à presidência, como esse lugar se configura em suas respectivas campanhas. Para tanto, selecionamos para análise trechos dos planos de governo e publicações desses presidenciáveis feitas nas redes sociais Twitter e Facebook durante o período de campanha eleitoral. Após a seleção e a catalogação dos dados, realizamos a análise discursiva das materialidades, com base nos pressupostos teóricos da Escola Francesa de Análise de Discurso, principalmente, nas noções de posição-sujeito e de porta-voz. Os resultados indicam que, no acontecimento discursivo das eleições presidenciais de 2018, a figura enunciativa do porta-voz, identificada na campanha eleitoral dos três candidatos, apesar de falar em nome de uma coletividade, não representa a vontade de um povo brasileiro uno e indiviso, pois a forma de tais candidatos se identificarem com o lugar discursivo do porta-voz aponta para a deriva de sentidos, indicando que essa suposta unidade do “povo brasileiro” é apenas um efeito relacionado à ilusão subjetiva.
Leadless pacemakers in critically ill patients requiring prolonged cardiac pacing; a multicenter international study.
Authors: Clementy Nicolas , Coelho Roxane , Veltmann Christian , Marijon Eloi , Tolosana Jose Maria , Galand Vincent , Ploux Sylvain , Eschalier Romain , Simeon Edouard , Blessberger Hermann , Müller-Leisse Johanna , Pujol-Lopez Margarida , Martins Raphael , Ritter Philippe , Steinwender Clemens , Babuty Dominique
Published: March 2021

Background: Temporary transvenous pacing in critically ill patients
requiring prolonged cardiac pacing is associated with a high risk of
complications. We sought to evaluate the safety and efficacy of
self-contained intracardiac leadless pacemaker (LPM) implantation in
this population. Methods and Results: Consecutive patients implanted
with a Micra LPM during the hospitalization in an intensive care unit
were retrospectively included. Inclusion criteria were: ≥1 supracaval
central venous, or a ventilation tube, or intravenous antibiotic therapy
for ongoing sepsis or bacteremia. Patients with a history of previous
implantation of a pacemaker were excluded. Out of 1,016 patients
implanted with an LPM, 99 met the inclusion criteria. Mean age was 75
years and Charlson comorbidity index 7. LPM implantation was
successfully performed in 98% of cases, with a peri-operative
complication rate of 5%, mainly cardiac injuries. In-hospital mortality
rate was 6%. No late (>30 days) device-related
complication occurred, especially no infection. Conclusions: LPM appears
as an acceptable alternative to conventional temporary transvenous
pacing in selected critically ill patients requiring prolonged cardiac
pacing, especially regarding the risk of infection.
Impacts of Groundwater Flow on Evolution of a Thermokarst Lake in the Permafrost Region on the Qinghai-Tibet Plateau
Authors: Wang Wei , Li Jinlong , Ke Xianmin , Chen Kai , Gao Zeyong , Niu Fujun
Published: March 2021

Thermokarst lakes and permafrost degradation in the Qinghai-Tibet
Plateau (QTP) resulting from global warming have been considerably
affected the local hydrological and ecological process in recent
decades. Simulation with coupled moisture-heat models that follows talik
formation in the Beiluhe Basin (BLB) in the hinterland of permafrost
regions on the QTP provides insight into the interaction between
groundwater flow and freezing-thawing process. A total of 30 modified
SUTRA schemes have been established to examine the effect of
hydrodynamic forces, permeability and climate. The simulated results
show that the hydrodynamic conditions impact the permafrost degradation
surrounding the lake, thereby further affecting groundwater flow and
late-stage freezing-thawing process. The thickness of the active layer
varies with time and location under different permeability conditions,
which significantly influences the occurrence of a breakthrough of the
lake bottom. Warmer climate accelerates thawing and decreases the
required time of formation of the breakthrough zone. Overall, these
results indicate that explicit consideration of hydrologic process is
critical to improve the understanding of environmental and ecological
changes in cold regions.
Exogenous Fatty Acid Hydroperoxide Perception as Elicitor Is Related to Modulation of Plant Plasma Membrane Structure
Authors: Deboever Estelle , Aubel Géraldine van , Rondelli Valeria , Koutsioumpas Alexandros , Mathelie-Guinlet Marion , Dufrêne Yves , Ongena Marc , Lins Laurence , Cutsem Pierre Van , Fauconnier Marie-Laure , Deleu Magali
Published: March 2021

Fatty acid hydroperoxides (HPOs) are amphiphilic molecules naturally
produced by plants in stressed conditions and involved in plant immunity
as signalling molecules. Although some studies report their potential
use as exogenous biocontrol agents for plant protection, evaluation of
their efficiency in planta is lacking and no information is available
about their mechanism of action. In this work, the potential of two HPO
forms, 13-HPOD and 13-HPOT, as plant defence elicitors and the
underlying mechanism of action are investigated. Both HPOs trigger
Arabidopsis innate immunity. They increase plant resistance to the
pathogenic fungi Botrytis cinerea and activate early immunity-related
defence responses, like ROS production. As our previous study has
suggested that HPOs are able to interact with the plant plasma membrane
(PPM) lipid fraction, we have further investigated the effects of HPOs
on biomimetic PPM structure using complementary biophysics tools.
Results show that HPO insertion into PPM impacts its global structure
without solubilizing it. 13-HPOT, with an additional double bond
compared to 13-HPOD, exerts a higher effect by fluidifying and reducing
the thickness of the bilayer. Correlation between biological assays and
biophysical analysis suggests that lipid amphiphilic elicitors that
directly act on membrane lipids might trigger early plant defence
events.
Determinants for under- and overdosing of direct oral anticoagulants and physicians' implementation of clinical pharmacists' recommendations
Authors: Moudallel Souad , Cornu Pieter , Dupont Alain , Steurbaut Stephane
Published: March 2021

Aim: To analyze the appropriateness of DOAC dosing and determinants for
under-and overdosing as well as acceptance and implementation rates of
interventions by clinical pharmacists. Methods: Cross-sectional study
from January 2019-December 2019 in a tertiary hospital in hospitalized
patients with atrial fibrillation on DOACs (n=1688). Primary outcome was
the proportion of patients with inappropriate DOAC prescribing with
identification of determinants for under-and overdosing. Secondary
outcomes included acceptance and implementation rates of pharmacists’
advices and determination of reasons for
non-acceptance/non-implementation. Results: In 16.9% of patients,
inappropriate prescribing was observed. For all DOACs considered
together, body weight<60 kg(OR 0.46 [0.27-0.77]), edoxaban
use(OR 0.42 [0.24-0.74]), undergoing surgery(OR 0.57
[0.37-0.87]) and being DOAC naïve(OR 0.45 [0.29-0.71]) were
associated with a significantly lower odds of underdosing. Bleeding
history(OR 1.86 [1.24-2.80]) and narcotic use(OR 1.67
[1.13-2.46]) were associated with a significantly higher odds for
underdosing. Determinants with a significantly higher odds of overdosing
were renal impairment(OR 11.29 [6.23-20.45]) and body
weight<60 kg(OR 2.34 [1.42-3.85]), whereas the use of
dabigatran(OR 0.24 [0.08-0.71]) and apixaban(OR 0.18
[0.10-0.32]) were associated with a significantly lower odds of
overdosing compared to rivaroxaban. Physicians accepted the pharmacists’
advice in 179 cases (79.2%) consisting of 92 (51.4%) advices for
underdosing, 82 (45.8%) for overdosing and 5 (2.8%) for
contraindications. The advices were effectively implemented for 75
(81.5%) underdosed, 69 (84.1%) overdosed and 4 (80.0%)
contraindicated cases. Conclusion: Inappropriate DOAC prescribing
remains common. Clinical services led by pharmacists helps physicians to
reduce the number of inadequate prescriptions for high risk medications
such as DOACs.
Risk identification in tunnel construction project: A literature review
Authors: Mauretta Sihombing , Purba Humiras , Purba Aleksander
Published: March 2021

Every construction project is always faced with the possibility of various
occurrence kinds of risks. The higher the level of complexity of a project,
the greater the level of risk that might happen to the project. Based on
historical data from tunnel construction many problems and even failure of
tunnel construction caused by various factors has been noted and it can have
an impact on project delays. A risk management is expected to reduce the
adverse impact of risks faced during construction work. Tunnel construction
needs management handling with high risk, so it is necessary to identify
risks that can minimize bad risks. A risk management is expected to reduce
the adverse effects of risks faced in a construction work. It is necessary
to perform risk identification to manage the risks that we will face. To
successfully improve the performance of tunnel projects, we need to identify
various risk factors in a project for efficient project fulfillment. The
research method begins with an extensive literature review by reviewing at
least 48 journal, journal papers, review articles to provide a list of the
main risk factors which are also added to the expertise to achieve a list of
final risk factors that contain all risks that may be encountered during
road construction. This analysis involves the identification, classification
of various risks involved in the construction of a tunnel construction
project.
Cardiovascular and Renal Disease Burden in Type 1 Compared With Type 2 Diabetes: A Two-Country Nationwide Observational Study
Authors: Kristófi Robin , Bodegard Johan , Norhammar Anna , Thuresson Marcus , Nathanson David , Nyström Thomas , Birkeland Kåre I , Eriksson Jan W
Published: March 2021

Objective: Type 1 (T1D) and type 2
diabetes (T2D) increase risks of cardiovascular and renal disease (CVRD)
compared to diabetes-free populations. Direct comparisons between T1D and T2D
are scarce. We examined this by pooling full-population cohorts in Sweden and
Norway.

Research Design and Methods: 59,331
T1D and 484,241 T2D patients, aged 18-84 years, were followed over a mean period
of 2.6 years from December 31, 2013. Patients were identified in nationwide prescribed
drug and hospital registries in Norway and Sweden. Prevalence and event rates
of myocardial infarction (MI), heart failure (HF), stroke, chronic kidney
disease (CKD), all-cause death and cardiovascular death were assessed following
age stratification in 5-year intervals. Cox regression analyses were used to estimate
risk.

Results: The prevalence of cardiovascular
disease was similar in T1D and T2D across age strata, whereas CKD was more
common in T1D. Age-adjusted event-rates comparing T1D versus T2D showed that HF
risk was increased between the ages 65-79 years, MI between 55-79 years and
stroke between 40-54 years, 1.3-1.4-fold, 1.3-1.8-fold and 1.4-1.7 fold respectively.
CKD risk was 1.4-3.0-fold higher in T1D at all ages. The all-cause death risk was
1.2-1.5-fold higher in T1D above 50 years, with a similar trend for CV death.

Conclusions: Adult T1D compared to T2D patients
had an overall greater risk of cardiorenal disease (heart failure and CKD) across ages, of MI and
all-cause death at middle-older ages and of stroke at younger ages. The total age-adjusted
CVRD burden and risks were greater among T1D patients compared to T2D, highlighting
their need for improved prevention strategies.
Agon, composición electroacústica de Horacio Vaggione: una propuesta metodológica de análisis
Authors: Santillán Varela Luis Antonio , Ammetto Fabrizio , Béjar Bartolo Alejandra
Published: March 2021

En este artículo se presenta la obra electroacústica Agon (1998) del compositor argentino Horacio Vaggione (1943-), relacionada con dos composiciones anteriores del mismo autor: Schall (1995) y Nodal (1997). Se ofrece una propuesta metodológica de análisis musical basada en los conceptos y reflexiones del propio compositor (tales como micromontaje, mixidad, procesamiento, etc.), con el objetivo de apreciar todas sus dimensiones y componentes, así como sus técnicas de realización y estructuración, todo lo anterior con el fin último de proponer una mejor recepción y apreciación de esta obra.
Finite element analysis of microclimate parameters in the metallurgical crane cabin
Authors:   Don State Technical University, Rostov-on-Don, Russian Federation, Maslenskiy V. V. , Bulygin Yu. I. ,   Don State Technical University, Rostov-on-Don, Russian Federation
Published: March 2021

Introduction. The article analyzes the microclimate parameters (temperature, speed and air pressure) in the metallurgical crane cabin provided by the air conditioning system using the finite element method integrated into the ANSYS software package. The metallurgical crane cabin air conditioning system was selected based on the engineering calculation of the required air flow rate supply, taking into account factors that affect the system performance, such as the location of the equipment and the degree of its dustiness. Problem Statement. The purpose of this research was to check the efficiency of the air conditioning system of the metallurgical crane cabin, which was selected based on the results of the engineering calculations. Theoretical Part. In the main part of the research, the distribution fields of temperature, speed and air pressure inside the cabin of a metallurgical crane were constructed, the values at the points of which were compared with the hygienic standards. In addition, the factors that affect the adequacy of the developed model were considered, namely the grid structure, the way to set the initial and boundary conditions. Conclusion. The refinement of the analysis grid and the consideration of infiltration in the model eventually allowed us to get more correct results: the temperature at the characteristic points differ by no more than 1.3 °C, the speed values do not exceed the standard 0.3 m/s, the average normalized temperature of 24 °C is maintained in a volume of about 60-70 % of the total cabin volume.
Using Telehealth to Enhance Pediatric Psychiatric Clinical Simulation: Rising to Meet the COVID-19 Challenge
Authors: Whited Teresa Michelle , Stickley Kimberly , De Gravelles Pamela , Steele Taylor , English Beverly
Published: March 2021

Securing clinical locations for Bachelor of Nursing Science (BSN) programs is always a complex challenge, particularly when clinical experiences are focused on vulnerable populations such as pediatric psychiatric patients.  To provide students with a meaningful clinical experience during the first weeks of the COVID-19 pandemic, we developed a telehealth simulation centered on a pediatric psychiatric patient with unfolding adolescent depression and suicidal ideation. This case study uses qualitative data analysis of student debriefing sessions as well as a pre/post test design to explore the effectiveness of the simulation. Results suggest that simulations can be useful for presenting unique patient scenarios focused on therapeutic communication in psychiatric assessment, particularly for vulnerable patient populations. Quantitative data analysis showed BSN students improved their understanding of communication needs of adolescents and retained their knowledge over time; qualitative comments showed that students felt the simulation was a valuable learning experience and achieved key learning outcomes.
A Light in Students’ Lives: K-12 Teachers’ Experiences (Re)Building Caring Relationships During Remote Learning
Authors: Miller Karyn E.
Published: March 2021

This study illuminates the experiences of K-12 educators as they strove to (re)build caring relationships with students during the COVID-19 pandemic. The study was conducted during a graduate course for experienced K-12 teachers in the spring of 2020 at a four-year comprehensive university in the United States. Data was collected from reflective learning journals and asynchronous peer discussions, which captured educators’ experiences as they transitioned to remote learning in real-time. Qualitative content analysis was used to identify pertinent themes. Findings suggest that remote learning revealed relationships in need of repair. Educators practiced authentic care and cultivated connectedness by 1) acting as warm demanders, 2) responding to students’ social-emotional needs, and 3) trying to bridge the digital divide. The article concludes with implications for practice and areas for future research as schools, districts, states, and countries consider the “new normal” in K-12 schooling.
A Structural-Algorithmic and Parametric Synthesis of Single-Phase Voltage Source Inverters for Increased Power Capacity
Authors:   NRU MPEI, MYTSYK GENNADY S. , HEIN ZAW HTET ,   NRU MPEI
Published: March 2021

The recent interest of developers of new technology in studying a structural and algorithmic synthesis (SAS) of voltage source inverters (VSI) for solar power plants (SPP) is stemming from a growing need to solve problems in connection with the revealed new possibilities of converting energy flow (from DC to AC) with better energy efficiency by reducing the depth of its pulse modulation. This problem is solved by using more rational structural and algorithmic solutions. It is shown that for SPPs for a capacity of about 1 MW and more, it is more expedient to construct inverters based on the energy flow multichannel conversion principle. Given a limited power capacity of the transistor components, the application of this principle allows the problem to be solved in fact without using an output filter. The output voltage waveform is shaped using the energy flow pulse-amplitude modulation (PAM), and its M parts are summed in the output circuit by out using M winding transfilters (M-TF). The proposed method for carrying out combined SAS of single-phase voltage source inverters with multichannel conversion is considered, which consists in using an N-level single-phase VSI (N-SPVSI) in each of the M channels with the voltage levels optimized in terms of the minimum total harmonic distortion (THD). The resulting voltage of this class of single-phase inverters, designated as MxN-SPVSI, is formed by the corresponding phase shift of the channel voltages followed by summing the channel currents by M-TF. It is shown that the resulting output voltage levels are also close to their values optimized with respect to the minimum of the THD indicator. The results from a comparative analysis of two options — a single-channel 8-level inverter and a four-channel 8-level inverter are given. For the second option, only one intermediate voltage tap in the solar battery is required (instead of seven taps in the first option) along with modern transistor components that are available for practical implementation. In both options, the THD value less than 5% is obtained with almost no need of using an output filter. The presented results provide a certain information and methodological support for system designing of single-phase voltage source inverters as applied to the specific features of solar power plants. Three-phase inverters can be built on the basis of three single-phase inverters with galvanic isolation of the power sources for each phase.
Development of Predictive Model for Helper T Lymphocyte Epitope Binding to HLADRB1* 01:01
Authors: Hardianto Ari , Yusuf Muhammad
Published: March 2021

Epitopes are essential peptides for immune system stimulation, such as governing helper T lymphocyte (HTL) activation via antigen presentation and recognition. Current predictive models for epitope selection mainly rely on the antigen presentation, although HTLs only recognize 50% of the presented peptides. Thus, we developed a HTL epitope predictor which involves the antigen recognition step. The predictor is specific for epitopes presented by Human Leukocyte Allele (HLA)-DRB1*01:01, which is protective against developing multiple sclerosis and association with autoimmune diseases. As the data set, we used binding register of immunogenic and non-immunogenic HTL peptides related to HLA-DRB1*01:01. The binding registers were obtained from consensus results of two current HLA-binder predictors. Amino acid descriptors were extracted from the binding registers and subjected to random forest algorithm. A threshold optimization were applied to overcome data set imbalance class. In addition, descriptors were screened by using a recursive feature elimination to enhance the model performance. The obtained model shows that the hydrophobicity, steric, and electrostatic properties of epitopes, mainly at center of binding registers, are important for the TCR recognition as well as the HTL epitopes predictive model. The model complements current HLA-DRB1*01:01-binder prediction methods to screen immunogenic HTL epitopes.
Latencias de respuesta de lectura en español: efectos de lexicalidad y frecuencia
Authors: Difalcis Micaela , Ferreres Aldo , Osiadacz Natalia , Abusamra Valeria
Published: March 2021

El objetivo de este trabajo fue diseñar y aplicar una prueba de palabras y no palabras (PaNoPa) para estudiar las latencias de respuesta de lectura en una muestra de sujetos hispanohablantes. Un único estudio previo había informado tales efectos pero la prueba empleada no controlaba variables lexicales (número y frecuencia de vecinos ortográficos) ni sublexicales (frecuencia de bigramas y fonemas iniciales) que son importantes para la medición correcta de las latencias. La determinación fehaciente de los efectos de lexicalidad y frecuencia en participantes controles es relevante para la discusión sobre la universalidad de los modelos psicolingüísticos de lectura y también para la caracterización de las alteraciones de la lectura por lesiones cerebrales (alexias o acquired dyslexia) en sujetos hispanohablantes. Con una prueba exhaustivamente controlada se obtuvieron las latencias de lectura en una muestra de lectores hispanohablantes y se llevó a cabo un análisis ANOVA por sujeto y por tipo de estímulo. Los resultados mostraron latencias significativamente menores para palabras respecto de no palabras (efecto de lexicalidad) y para palabras frecuentes respecto de palabras infrecuentes (efecto de frecuencia). También se encontró una diferencia significativa entre las latencias de las palabras no frecuentes y las no palabras. Estos hallazgos aportan evidencia a favor de la existencia de una ruta léxica de lectura en una lengua transparente como el español y proveen una herramienta y datos para el estudio psicolingüístico de las alteraciones de la lectura de sujetos hispanohablantes con alexia.
Caracterização mineralógica do túnel da PCH Garça Branca e a primeira ocorrência de analcima no estado de Santa Catarina, Brasil
Authors: Fonseca Anísio Cláudio , Sato Rodrigo Del Olmo , De Menezes Maurício Thadeu Fenilli , Fonseca Alexandre Cláudio Rios
Published: March 2021

Introdução: Diferentes minerais têm sido encontrados nas cavidades das rochas vulcânicas do Grupo Serra Geral, Bacia do Paraná e no ano de 2016, durante perfuração de um túnel para uma barragem no munícipio de Anchieta- SC, foram encontrados cristais deltoide-icositeraédricos de analcima atapetando cavidades e vesículas nas rochas, associados a outros minerais. Objetivos: Confirmar a identidade do mineral como analcima e definir as fácies minerais na extensão do túnel. Metodologia: Aferição de hábito, dimensões, cor, brilho, traço, fluorescência UV-L, densidade, perda ao fogo, clivagem, fratura, diafaneidade, tenacidade e difração de raios X (DRX). Resultados: Hábito isométrico trapezoédrico icosaedro com dimensões de até cinco centímetros, incolor a branco, translúcido a opaco, brilho vítreo, fratura subconchoidal, clivagem fraca. Na mufla a 300ºC por 60 minutos torna-se branco e friável. A densidade média é de 2,26 g/cm³, dureza Mohs 5 a 5,5, traço branco, cor branca, perda ao fogo de 7,95% e raios X com picos característicos para analcima. Discussão: Ocorre in situ em cinco fácies: Analcima e Mordenita/Escolecita (cristais superficiais e inclusos); Analcimas isoladas euedrais com até 5 cm; Analcima e Estilbita-Ca com marcas de dissolução; Analcima e calcita com hábito trigonal; Analcima e Estilbita-Ca euédrica, maclada e sem dissolução. Conclusão: Os ensaios realizados confirmaram a espécie mineral analcima (NaAlSi2O6.H2O), sendo um importante registro da ocorrência no Estado de Santa Catarina.
Sterilization potential of Ascaris lumbricoides eggs in the presence of different disinfectant agents
Authors: Barbosa Fernando Sérgio , Leite Mariela Helena , De Faria Mariana Teixeira , Gontijo Bruna de Alcântara Veloso , Fontes Guilherme Pereira , Severino Amanda Martins , Martins Ivani Pose
Published: March 2021

Introduction: Intestinal parasitic infections represent a public health problem, being responsible for high rates of morbidity and mortality.  Ascaris lumbricoides is one of the main parasites prevalent in the community.  The A. lumbricoides infection method is oral fecal cicle, in this sense, it is necessary to expand effective methods to prevent the ingestion of eggs, such as sanitation, cleansing habits or even effective methods for the sterilization of eggs. Objective: Evaluate different agents of antisepsis action, with the purpose of find which ones are more efficient in larval mortality inside eggs. Methodology: The parasites were provided by the Federal University of Minas Gerais, which were sectioned, in this way, the recovered eggs were kept in culture bottles.  After 40 days the embryonated eggs were purified and separated in culture bottles, and in each bottle had one different disinfectant products were added, in different concentrations and action time.  As control, egg aliquots were maintained by adding distilled water.  Using a microscope, it was observed the viability of the larvae inside.  To determine the viability of the larvae, distilled water at 40 °C was added, then allowing the visualization of mobility inside the eggs. Results: It was observed that, fifteen disinfectant agents tested, only four showed efficacy, at intervals of 24 and 48 hours after exposure to the disinfectant and when undiluted. Conclusion: The data obtained in this study will contribute to the understanding of the epidemiology of this disease, as well as contributing to the development of more effective hygiene programs for the control of this parasitosis.
Wpływ transformacji ustrojowej na zmiany strukturalne w przemyśle województwa toruńskiego
Authors: Gierańczyk Wiesława
Published: March 2021

Urynkowienie gospodarki na początku lat dziewięćdziesiątych miało wyraźny wpływ na zmiany w przemyśle całej Polski. Regres, który zaznaczył się m.in. spadkiem produkcji, zatrudnienia, wzrostem cen, trudnościami ze zbytem oraz pozyskiwaniem środków finansowych, dotknął większość branż przemysłu woj. toruńskiego. Terapia „szokowa” wyrażona m.in. liberalizacją większości cen, nałożeniem ostrych hamulców na wszelkie źródła wypływu pieniądza na rynek, wprowadzeniem niezwykle wysokiego podatku od ponadnormatywnych wynagrodzeń oraz wzrostem stopy oprocentowania kredytów, przyczyniła się do obniżenia produkcji sprzedanej w latach 1990–1991 o prawie jedną trzecią, podczas gdy w latach osiemdziesiątych dynamika produkcji sprzedanej wzrastała przeciętnie o 5%