bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of a pyraclostrobin-based fungicide in plant and green microalgae models
Authors: Oliveira Tamires de Freitas , Costa Maria Vaz da , Santos Tamara , Wisniewiski Maria dos Santos , Andrade-Vieira Larissa
Published: May 2024

Pyraclostrobin-based fungicides play an effective role in the control of fungal diseases and are extensively used in the agricultural sector. However, there is growing concern regarding the potential effects of these fungicides on nontarget organisms and the influence they exert on ecosystem functioning. Given this concern, it is essential to conduct comprehensive studies with model organisms to understand the impacts of these fungicides on different groups of living organisms. In this study, the ecotoxicity of a commercial fungicide containing pyraclostrobin was evaluated. The focus of the analysis was on the germination and initial development of seedlings of four plant models (Lactuca sativa, Raphanus sativus, Pennisetum glaucum and Triticum aestivum), in addition to evaluating the population growth rate and total carbohydrate content in the microalga Raphidocelis subcapitata. The fungicide negatively influenced the growth and development of the tested plants, indicating its toxic effect. The fungicide had a significant impact on the initial development of seedlings of all the model species evaluated, and T. aestivum plants exhibited the greatest susceptibility to pyraclostrobin. Plants of this species exhibited inhibitory effects on both the aerial parts and roots when treated with at a concentration of 4.75 mg/L. In addition, the green microalga R. subcapitata was also significantly affected by the fungicide, especially at relatively high concentrations, which resulted in a reduction in the total carbohydrate content. The pyraclostrobin-based fungicide showed phytotoxic potential for the model plant species tested in this study and was shown to be a highly toxic contaminant for the aquatic environment.
A new method employing extraction induced by emulsion breaking and MIP OES for multi-element determination of inorganic elements in handmade chocolate
Authors: Guimarães Geovana Brito , Guimarães Leonardo Brito , Romero Julia Carneiro , Queiroz Sheylla , Lima Daniel de Castro , Santos Luana Novaes , Silva Erik Galvão Paranhos da , de Jesus Raildo Mota , Dias Fábio de Souza , Lepri Fábio Grandis , Silva Allison Gonçalves , Amorim Fábio Alan Carqueija
Published: May 2024

The objective of this work was the multielement determination of Ca, Zn, Sr, Ba, Cu, Mn, Mg and Cr in chocolate barr samples after extraction induced by emulsion breakage (EIEB) and quantification by optical emission spectrometry whit plasma induced by microwaves (MIP OES). After study of each parameter, the most efficient extraction conditions were obtained using 0.250 g of sample, 5.0 mL of extraction solution consisting of HNO3 1.5 mol L− 1 and Tween80 1.5% m/v, submitted to an ultrasonic bath for 5 min, followed by breaking the emulsion by heating at 90 ºC in a water bath for 4 min. The detection limits obtained, in mg kg− 1, were 0,3487 (Cr), 0,0125 (Zn), 0,0635 (Sr), 0,0831 (Ca), 0,4627 (Fe), 0,0101 (Ba), 0,0991, (Cu), 0,0161 (Mg), 0,0356 (Mn). Precision, based on the relative standard deviation (RSD%), was less than 9.8% (N = 7). The accuracy was confirmed by analyzing the SRM Baking Chocolate 2384 and comparing the proposed method with a calcination method. The method was applied to samples of chocolate bars made in the southern region of Bahia and containing cocoa contents at 50, 58, 60, 63, 70, 80 and 85%. The average results obtained were 328 to 1424 mg kg− 1 (Ca), 561 to 2152 mg kg− 1 (Mg), 7.8 to 251 mg kg− 1 (Cu), 8.5 to 304 mg kg− 1 (Mn), 6.22 to 98.32 mg kg− 1 (Fe), 8.38 to 80.2 mg kg− 1 (Zn), 3.4 to 175 mg kg− 1 (Ba), 2.15 to 12.79 mg kg− 1 (Sr). It was observed that as the percentage increases cocoa, there is a tendency to increase the concentration of the studied elements. The developed method has satisfactory precision and accuracy, and is simple, fast and with low consumption of reagents, has good sensitivity, especially when compared to digestion methods.
OSSDetector: Towards a More Accurate Approach for C/C++ Third-Party Library Detection
Authors: Zeng Jia , Zhu Yaling , Han Dan , Weng Fangchen , Li Ruidong , Zhang Yuqing
Published: May 2024

In the current software development environment, third-party libraries (TPL) provide developers with rich functionality and convenient solutions, accelerating the speed and efficiency of software development. However, with the widespread adoption of TPL, related security risks have become increasingly apparent. Software Composition Analysis (SCA) is crucial for detecting and managing TPLs in software projects to address these growing security challenges. However, existing SCA tools for C/C++ software projects face several challenges, including the consequences of modified and nested TPL, the lack of precise version representation, and a comprehensive TPL database. Unfortunately, existing SCA tools are inadequate in addressing these challenges and do not detect the precise TPL version. We propose a new SCA tool called OSSDetector to identify TPLs and TPL versions in C/C++ projects to alleviate these issues. OSSDetector, based on sliding window and fuzzy hashing techniques, generates finer-grained signatures to identify modified TPL and mitigate its consequences. Furthermore, it uses a “Nested TPL Function Filtering" algorithm based on multiple features to identify and filter nested TPL function signatures in each TPL to mitigate the consequences of nested TPL. Additionally, it leverages a “TPL Recognition" algorithm based on import ratios and function paths to determine the TPL used in the target C/C++ software. It also determines TPL versions based on function weights and version release times to mitigate the lack of precise version representation. To mitigate the lack of a comprehensive TPL database, we construct a large TPL database containing 29,416 C/C++ TPLs covering 767,405 versions. Experimental results demonstrate that compared to state-of-the-art tools, OSSDetector achieves better precision (85.52%), recall (79.82%), and F1 score (82.57%) at the library level, with improvements of 3.18%, 3.59%, and 3.40%, respectively. At the library version level, OSSDetector also exhibits higher precision (84.27%), outperforming state-of-the-art tools by 4.64%.
A Parameter-uniform Hybrid Scheme Designed for Multi-pointboundary Value Problems That Are Perturbed
Authors: Kumari Parvin , Kumar Devendra , Vigo-Aguiar Jesus
Published: May 2024

The numerical solution of a class of second-order singularly perturbed three-point boundary value problems (BVPs) in 1D is achieved using a uniformly convergent, stable, and efficient difference method on a piecewise-uniform mesh. The presence of a boundary layer(s) on one (or both) of the interval’s endpoints is caused by the presence of the tiny parameter in the highest order derivative. As the perturbation parameter approaches 0, traditional numerical techniques on the uniform mesh become insufficient, resulting in poor accuracy and large blows without the use of an excessive number of points. Specially customised techniques, such as fitted operator methods or methods linked to adapted or fitted meshes that solve essential characteristics such as boundary and/or inner layers, are necessary to overcome this drawback. We developed a fitted-mesh technique in this paper that works for all perturbation parameter values. The monotone hybrid technique, which includes midway upwinding in the outer area and centre differencing in the layer region on a fitted-mesh condensing in the border layer region, is the basis for our difference scheme. In a discrete L∞ norm, uniform error estimates are constructed, and the technique is demonstrated to be parameter-uniform convergent of order two (up to a logarithmic factor). To show the effectiveness of the recommended technique and to corroborate the theoretical findings, a numerical example is presented. In practise, the convergence obtained matches the theoretical expectations.
AMS subject classifications. 34B05, 34B10, 35B08, 65L11, 65L12, 65L70
The formation and alteration of macrofungal “small islands” from the Qinling Mountains based on a novel DNA metabarcoding identification method
Authors: Huo Wenyan , Cui Langjun , Yan Pengdong , He Xuelian , Zhang Liguang , Liu Yu , Dai Lu , Qi Peng , Hu Suying , Qiao Ting , Li Junzhi
Published: May 2024

Sporocarps of macrofungi support other diverse fungal species that are termed fungicolous fungi. However, a pipeline for the simultaneous processing and analysis of macrofungi and their fungicolous fungi, in addition to the external environmental factors that affect the diversity and composition of fungicolous fungal communities, remains largely unknown. In this study, a novel specialized pipeline was constructed to automatically analyze the sequence diversity of host macrofungi along with their associated fungicolous fungi. Moreover, the alpha and beta diversities of fungicolous fungal communities residing in host macrofungi from diverse habitats in the Qinling Mountains were analyzed, revealing that the diversity and composition of fungicolous fungal communities varied with host growth month and habitats. Furthermore, saprophytic fungi had greater abundances of cell wall degrading enzymes than parasitic and symbiotic fungi, potentially explaining why saprophytic fungi grew more abundant on wood, and revealing the formation mechanism of “small islands” growing on wood.
Attention-Enhanced Controllable Disentanglement for Cloth-Changing Person Re-identification
Authors: Ge Yiyuan , Yu Mingxin , Chen Zhihao , Lu Wenshuai , Dai Yuxiang , Shi Huiyu
Published: May 2024

Cloth-changing person re-identification (Re-ID) is an emerging research theme that aims at identifying individuals after clothing change. Many contemporary approaches focus on disentangling clothing features and solely employ clothing-unrelated parts for identification. However, the absence of ground truth poses a significant challenge to the disentanglement process, these methods may introduce unintended noise and degrade the overall performance. To mitigate this issue, we propose a novel framework, termed Attention-based Controllable Disentanglement Network (ACD-Net). In ACD-Net, we design an Attention-enhanced Disentanglement Branch (ADB) where human parsing masks are introduced to guide the separation of clothing features and clothing-unrelated features. Here, clothing-unrelated features are subdivided into unclothed body features and contour features, and we propose two novel attention mechanisms: Dynamic Interaction-Remote Aggregation Attention (DI-RAA) and Dynamic Interaction-Positional Relevance Attention (DI-PRA) to enhance the representations of these two features, respectively. Experimental results on PRCC, LTCC, DeepChange, and CCVID datasets demonstrate the superiority of our approach over the state-of-the-art methods. For the cloth-changing setting, the mAP of our network on PRCC, LTCC, and DeepChangedatasets are 59.5%, 22.6%, and 20.6%, and the Rank-1 are 60.6%, 45.5%, and 56.8%, respectively. In addition, our model also obtains 81.5% of mAP and 83.4% of Rank-1 on the video dataset CCVID. The code is available at: https://github.com/jk-love-ge/ACDNet.
Graph Augmentation against Structural Poisoning Attacks via Structure and Attribute Reconciliation
Authors: Shao Yifan , Dai Yumeng , Wang Chenxu , Guan Xiaohong
Published: May 2024

Recent years have witnessed the great success of graph neural networks (GNNs) in various graph data mining tasks. However, studies demonstrate that GNNs are vulnerable to imperceptible structural perturbations. Carefully crafted perturbations of few edges can significantly degrade the performance of GNNs. Many useful defense methods have been developed to eliminate the impacts of adversarial edges. However, existing approaches ignore the mutual corroboration effects of structures and attributes, which can be used for graph augmentation. This paper presents GAF, a novel graph Augmentation framework defending GNNs against structural poisoning attacks via structure and attribute reconciliation. GAF first constructs two auxiliary graphs, including an attributive neighborhood graph and a structural neighborhood graph, to augment the original one. We propose a novel graph purification scheme to prune irrelevant edges and assign the rest edges with different weights based on both node attributes and graph structures. This significantly mitigates the inconsistency between structural and attributive data, reducing the impacts of adversarial and noisy edges. Then, a joint graph convolutional network (GCN) model is developed to encode the three graphs for representation learning. Experimental results show that GAF outperforms state-of-the-art approaches against various adversarial attacks and exhibits great superiority for attacks with high perturbation rates. Source code is available at: https://github.com/shaoyf9/GAF.
Multifunctional plasmonic gates using the effect of voltage on the surface plasmons frequency change
Authors: jafargholikhani fatemeh , kashaninia alireza , Sabbaghi-Nadooshan Reza
Published: May 2024

Considering the benefits of plasmonic technology in reducing the scattering limit on bends and low losses, as well as thesmall size of the element, the development of this technology has accelerated. In this paper, the effect of voltageapplication on changing the frequency of surface plasmons is investigated. By applying an external voltage to the metalplates and creating a magnetic field, the density of the electrons on the metal surface changes; thus, surface plasmonsresonance frequency shifts. To this end, a multifunctional plasmonic gate with a dimension of 95 nm × 95 nm wasdesigned and simulated to evaluate this effect. This structure is suitable for use as AND, NOR, NOT, XOR, and NAND gates.The contrast ratio between the change of state from logic "0" to logic "1" is approximately 29 dB, and the transfer ratio(transmittance ratio) of output in logic "1" is over 85%. The proposed device has low dimensions, a high contrast ratio,and a high transmittance ratio. This device uses four gates: AND, NOR, NOT, XOR, and NAND, which can be achieved inplasmonic integrated circuits with the wavelength division multiplexing (WDM) technique.
Experimental study of pinewood samples incorporating multiple flame-retardant additives under varied heat fluxes in a cone calorimeter
Authors: Zhang Xuelin , Joseph Paul , Guerrieri Maurice , Moinuddin Khalid , Arun Malavika
Published: May 2024

In this study, pristine pinewood samples and those treated with flame-retardant additives were examined to evaluate their fire risk. The combustion process was delineated into four stages: release of flammable volatile gases, reduction of thermal penetration depth, sample deformation to optimize heat absorption, and the onset of smoldering combustion involving char formation. It was discovered that the synergistic effects of 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO), triphenylphosphine (TPP), and (NH4)2HPO4 not only facilitated the decomposition of the samples but also lowered the surface temperature and diluted the oxygen concentration, thereby prolonging the ignition time, particularly at heat fluxes of 25 or 30 kWm− 2. The incorporation of Na2CO3 alongside other additives predominantly impacted the second stage of the combustion process, significantly contributing to the reduction of thermal penetration and dilution of oxygen concentration in combustion. The ignition time of the treated samples was at least 1.5 times longer than that of the untreated samples at lower heat flux. Notably, stable burning was more pronounced at higher heat fluxes for treated samples, and the mass loss rate of these samples was comparatively lower. The thermal penetration depth as a function expressed by ca. 0.8 \(\frac{\rho }{{\dot{q}}^{"}}\). The soot yield for both PA1 and PA2 increased with the heat flux rising and was approximately 0.006 kg/kg, at higher heat flux. The total heat release (THR) and total oxygen consumption (TOC) were observed to be lower for the treated samples. Upon analyzing the fire risk, it was determined that the performance of additive combination PA2 was superior, indicated by lower values in key risk indicators such as heat release rate, mass loss rate (MLR), and CO and CO2 yields. However, flashover propensity of PA2 ranges from 0.25 to 12.07, slight higher than that of PA3. Research is ongoing to further refine the formula to better meet human safety requirements.
Reversible Data Hiding for Recursion-PVO Based on Pixels Selection
Authors: Ge Bin , Shen Yaqing , Xia Chenxing , Sun Rui
Published: May 2024

Pixel value ordering (PVO) is one of the most commonly used methods in reversible data hiding (RDH). Most PVO methods currently chunk images, categorize them according to the space complexity of the chunks, and adopt different embedding strategies for different chunk categories. Although this approach achieves some results, the utilization of pixel redundancy is still insufficient. In order to expand the embedding capacity of RDH and improve the embedding performance, a high-fidelity reversible data hiding method based on pixels selection and recursion-PVO is proposed in this paper. Specially, for uniformly divided non-overlapping blocks, the set of pixels with the smallest and second-smallest variance values within each block is selected to form a new block to be embedded, thus further utilizing pixel redundancy. Then, the embedding capacity is improved by transforming some reference pixels into to-be-embedded pixels and forming pixel pairs with other reference pixels to calculate the prediction error. Experimental results show that the proposed method has better performance compared to some state-of-the-art methods. In particular, for the commonly used test image Lena, the PSNR after embedding 10,000 bits of data is up to 63.13 dB.
NS1 binding protein regulates stress granule dynamics and clearance by inhibiting p62 ubiquitination
Authors: Lee Jin-A , Jeon Pureum , Ham Hyunji , Choi Haneul , Park Semin , Jang Jae-Woo , Park Sang-Won , Cho Dong-Hyung , Lee Hyun-Jung , Song Hyun Kyu , Komatsu Masaaki , Jang Deok-Jin
Published: May 2024

NS1 binding protein (NS1-BP), a non-structural NS1-binding protein of influenza A virus, regulates viral or host RNA processing/export, cancer progression, or neurite/dendritic spine regulation. However, its precise roles in stress-induced responses without viral infection are largely unknown. Therefore, this study aims to investigate the novel roles of NS1-BP, which interact with GABARAP subfamily proteins, including LC3-interacting region-containing proteins, in regulating stress granules (SGs) during oxidative stress. NS1-BP interacts with core SG components and localizes to GABARAP-containing SGs during oxidative stress. Moreover, it associates with p62, acting as an adaptor for selective autophagy via its Kelch-motif and ubiquitin-associated domain in p62 in a stress-dependent manner. NS1-BP knockout (KO) HeLa cells demonstrated altered SG dynamics, mirroring observation in p62 KO or GABARAP triple KO cells, indicating impaired autophagic SG degradation. NS1-BP KO cells, compared to wild-type (WT) cells, showed increased p62 ubiquitination, leading to autophagic p62 degradation, while NS1-BP overexpression reduces p62 ubiquitination. In NS1-BP KO cells, overexpression of p62 WT, not p62 K420R or K435R, restored SGs size and number. Additionally, amyotrophic lateral sclerosis (ALS)-induced pluripotent stem cell-derived motor neurons showed reduced NS1-BP levels, resulting in SG morphology dysregulation. Our findings reveal the novel role of NS1-BP in negatively regulating p62 ubiquitination, influencing SG dynamics and clearance during oxidative stress. This highlights its relevance to ALS pathogenesis associated with SGs.
Classification of Paclitaxel-Resistant Cell Lines Using Gene Expression Analysis and Machine Learning Techniques
Authors: Madiseh Ali Abedi , Saboori Somayeh , Shahsavari Shiva
Published: May 2024

This paper presents a comprehensive study on the classification of paclitaxel-resistant cell lines based on gene expression analysis and machine learning algorithms. The dataset used in this study was obtained from the NCBI - GEO datasets, comprising three datasets that included gene expression profiles of four paclitaxel-resistant cell lines: BAS, HS578T, MCF7, and MDA-MB-231. The gene expression data was preprocessed by converting gene identifiers to gene symbols and calculated adjusts p-value, t-test, B-test and logFC using R and also added cell lines. Subsequently, various machine learning classifiers, including Random Forest, Support Vector Machine (SVM), Gaussian Naive Bayes, K-Nearest Neighbors (KNN), Decision Tree, and AdaBoost, were employed to classify the paclitaxel-resistant cell lines. The performance of the classifiers was evaluated using accuracy scores and confusion matrices.The performance of these classifiers was assessed through accuracy scores and confusion matrices. Our results demonstrated that Random Forest and SVM achieved the highest accuracy scores, outperforming other algorithms. These findings suggest the potential of gene expression data and machine learning approaches in accurately classifying paclitaxel-resistant cell lines, which can aid in predicting drug resistance and developing targeted therapies for breast cancer treatment.
TUMOUR THROMBUS ASSOCIATED WITH RENAL CELL CARCINOMA: A RARE CASE OF DELICATE SURGERY
Authors:   Urology Department, Military Hospital of Instruction Mohamed V, Hay Ryad - 10100 Rabat, Morocco., Larbi Hamedoun , Mohammed Tibouda ,   Anatomopathology Department, Military Hospital of Instruction Mohamed V, Hay Ryad - 10100 Rabat, Morocco., a Laalouabdelkrim ,   Visceral Surgery Department, Military Hospital of Instruction Mohamed V, Hay Ryad - 10100 Rabat, Morocco., Hassan Ilyass ,   Urology Department, Military Hospital of Instruction Mohamed V, Hay Ryad - 10100 Rabat, Morocco., Aziz Lamghari ,   Urology Department, Military Hospital of Instruction Mohamed V, Hay Ryad - 10100 Rabat, Morocco., Mohammed Mrabti ,   Urology Department, Military Hospital of Instruction Mohamed V, Hay Ryad - 10100 Rabat, Morocco., Younes Boukhlifi ,   Urology Department, Military Hospital of Instruction Mohamed V, Hay Ryad - 10100 Rabat, Morocco., Nabil Louardi ,   Urology Department, Military Hospital of Instruction Mohamed V, Hay Ryad - 10100 Rabat, Morocco., Abdessamad Elbahri ,   Urology Department, Military Hospital of Instruction Mohamed V, Hay Ryad - 10100 Rabat, Morocco., Mohammed Alami ,   Urology Department, Military Hospital of Instruction Mohamed V, Hay Ryad - 10100 Rabat, Morocco., Ahmed Ameur ,   Urology Department, Military Hospital of Instruction Mohamed V, Hay Ryad - 10100 Rabat, Morocco.
Published: May 2024

Metastatic renal cell carcinoma is in itself a serious and potentially fatal cancer, but when renal vein thrombus is added, the patients short-term prognosis worsens and surgery becomes even more complicated and mutilating. Four to ten per cent of kidney tumours invade the inferior vena cava and develop tumour extension into the renal vein and inferior vena cava. Only 1% has thrombus extension into the right atrium, a rare situation but one with a guarded prognosis. Cytoreductive nephrectomy is associated with an improvement in overall survival in patients without thrombus and in those with tumour thrombus limited to the renal vein and infra-diaphragmatic inferior vena cava with the advent of immunotherapy. Our article presents the case of a 73-year-old female patient who was admitted to Mohamed V Military Hospital of instruction for investigation of lumbar pain and imaging combined with a biopsy of the renal mass confirmed a metastatic renal tumour with thrombus extending to the junction of the renal vein with the inferior vena cava. The multidisciplinary consultation meeting decided to perform an extended total nephrectomy prior to systemic treatment and the challenge was to also remove the tumour thrombus from the renal vein and avoid any associated complications, which could be fatal.
PRIMARY HYPEROXALURIA TYPE I: FROM INFANTILE TO ADULT FORM WITH END-STAGE RENAL FAILURE: RARE CASE AND THERAPEUTIC ASPECTS
Authors:   Urology Department, Military Hospital of Instruction Mohamed V, Hay Ryad, 10100, RABAT, Morocco., Hamedoun Larbi , Zhim Imane ,   Pharmacy Division, Military Hospital of Instruction Mohamed V, Hay Ryad - 10100 Rabat, Morocco., Hassan Iliass ,   Urology Department, Military Hospital of Instruction Mohamed V, Hay Ryad, 10100, RABAT, Morocco., Conde Fadama ,   Urology Department, Military Hospital of Instruction Mohamed V, Hay Ryad, 10100, RABAT, Morocco., Elghazzaly Anouar ,   Urology Department, Military Hospital of Instruction Mohamed V, Hay Ryad, 10100, RABAT, Morocco., M. Alaa ,   Urology Department, Military Hospital of Instruction Mohamed V, Hay Ryad, 10100, RABAT, Morocco., a Sobhi ,   Urology Department, Military Hospital of Instruction Mohamed V, Hay Ryad, 10100, RABAT, Morocco., Louardi Nabil ,   Urology Department, Military Hospital of Instruction Mohamed V, Hay Ryad, 10100, RABAT, Morocco., Elbahri Abdessamad ,   Urology Department, Military Hospital of Instruction Mohamed V, Hay Ryad, 10100, RABAT, Morocco., Alami Mohammed ,   Urology Department, Military Hospital of Instruction Mohamed V, Hay Ryad, 10100, RABAT, Morocco., Ameur Ahmed ,   Urology Department, Military Hospital of Instruction Mohamed V, Hay Ryad, 10100, RABAT, Morocco.
Published: May 2024

Primary hyperoxaluria type I (HP1) is a very rare autosomal recessive inherited metabolic disease due to a hepatic alanine-glyoxylate aminotransferase (AGXT) enzyme deficiency. The result is excessive production and elimination of oxalate and glycolate leading to renal failure and systemic thesaurismosis. Diagnosis is based on oxaluria, followed by genotyping, as confirmation of the type of hyperoxaluria is essential for management and allows prenatal diagnosis. Conservative treatment (pyridoxine, hydration, crystallization inhibitors) is essential and must be early and the surgical management of recurrent calculi is very difficult, and requires the least invasive procedures possibleby experienced urologists in order to preserve as much renal parenchyma as possible. It is a serious disease that is often diagnosed late and its radical treatment requires costly and demanding hepato-renal replacement. Knowledge of thealanine-glyoxylate aminotransferase gene and genetic progress has made its prevention possible through prenatal diagnosis and genetic counseling. In this article, we present the case of a young patient treated for this rare disease since childhood to raise awareness among all medical staff, especially pediatricians, urologists and nephrologists, of this pathology which can be mitigated and whose progression can be slowed down if diagnosed at an early stage not like our patient necessitating liver-renal transplantation as the ultimate treatment.
SHOULD STAKEHOLDERS OF MATERNAL AND CHILD HEALTH CONSIDER DIGITAL HEALTH INNOVATIONS TO REDUCE INFANT MORTALITY RATES IN DEVELOPING COUNTRIES? - A WAKE UP CALL NEEDED TO ACHIEVE SDG 3.2.1
Authors:   Doctoral Student of Population Health Informatics, Dehradun Institute of Technology: DIT University., Adil Beig Mirza
Published: May 2024

This article draws attention to the need to prioritize the national budgets towards health planning and the importance of integrating innovative digital health solutions into thehealthcare systems especially in developing countries. It throws light on the increasing Infant Mortality Rates, especially newborn related deaths. Two countries Nigeria and India were chosen as the representative countries from among the developing countries to describe the Infant mortality rates and the need for digitalization. Examples of digital solutions and their impacts in creating awareness and reducing the infant mortality rates are quoted in this article. Digitalization is considered as easy to use, accessible way to improve health through proper implementation and political commitment of the nations.
THE IMPACT OF THE COVID-19 PANDEMIC ON THE INDIAN ECONOMY: CHALLENGES, DISRUPTIONS, AND PATHWAYS TO RECOVERY
Authors: Shandilya Samarth
Published: May 2024

The COVID-19 pandemic brought unprecedented challenges to the Indian economy, causing widespread disruptions across various sectors. This research paper examines the multifaceted impact of the pandemic, focusing on the nationwide lockdown imposed in March 2020 and its repercussions on employment, supply chains, consumer spending, and the overall economic landscape. Sectors such as hospitality, tourism, manufacturing, and retail bore the brunt of the crisis, while the plight of migrant workers underscored the vulnerability of Indias informal labor force. Amidst these challenges, the paper also explores the resilience and innovation demonstrated by certain sectors, such as technology and e-commerce. Furthermore, it discusses the lessons learned from the crisis and outlines potential pathways to economic recovery, emphasizing the importance of digital transformation and sustainable development in shaping Indias future economy.
DYNAMIC CHANGES ININFLAMMATORY PROFILES OF THYROID DYSFUNCTION: A COMPARATIVE ANALYSIS OF HYPERTHYROIDISM AND HYPOTHYROIDISM
Authors:   Department of Medical Laboratory Techniques, College of Paramedical Sciences, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India., Paliwal Shikha , Kant Ruchi ,   Department of Medical Laboratory Techniques, College of Paramedical Sciences, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India.
Published: May 2024

Introduction and Aim:The thyroid gland, an endocrine organ, produces vital hormones (T3 and T4) regulating metabolism. Thyroid-stimulating hormone (TSH) controls their release, impacting body tissues. C-reactive protein (CRP), an acute-phase protein, serves as a biomarker, crucial in diagnosing and managing various health conditions, particularly thyroid disorders. Elevated CRP levels often accompany thyroid dysfunction, highlighting the link between inflammation and thyroid disease pathogenesis, essential for diagnosis and management strategies. Methods: The research was conducted at the College of Paramedical Sciences, Teerthanker Mahaveer University &Teerthanker Mahaveer Hospital & Research Center, Moradabad in India, using random sampling. Blood sample was collected in the vacutainer and serum was separated for the clinical examination of CRP by turbidimetric immunoassay method. Clinical examinations were estimated in the biochemistry lab at the College of Paramedical Sciences by using a Semiautoanalyser. Results:The CRP levels in both hypothyroid and hyperthyroid groups were found higher as compared to euthyroid individuals, with mean CRP levels of 8.42 mg/dl, 5.67 mg/dl, and 5.05 mg/dl, respectively. A positive correlation between CRP and TSH is observed in hypothyroidism (r = 0.220). While hyperthyroidism exhibits slightly elevated CRP levels compared to healthy controls (5.67 mg/dl vs. 5.05 mg/dl), this difference lacks statistical significance (p>0.05). Notable variances in serum Hs-CRP levels are observed among individuals with hypothyroidism compared to euthyroidism (p<0.05), hyperthyroidism compared to euthyroidism (p>0.05), and hyperthyroidism compared to hypothyroidism (p<0.05), as determined by statistical analysis. Conclusion:A notable elevation in CRP levels among individuals with hypothyroidism and hyperthyroidism compared to those with euthyroidism. Additionally, a positive correlation is observed between CRP and TSH levels, particularly in the hypothyroid group. The disparities in Hs-CRP levels among different thyroid conditions underscore the link between thyroid function and inflammatory status.
EFFECTIVENESS OF CAREGIVER MEDIATED PSYCHOSOCIAL INTERVENTIONS ON BEHAVIOUR, ACADEMIC PERFORMANCE OF CHILDREN WITH ATTENTION DEFICIT HYPERACTIVITY DISORDER AT SELECTED SETTINGS
Authors:   Ph.D. Nursing Scholar., S. Avanthika , J. Hemavathy ,   Professor Cum Head of the Department of Mental Health Nursing, Omayal Achi College of Nursing., N. Jaya ,   Professor Cum Dean Shenbagha College of Nursing., D. Celina ,   Vice-Principal, Omayal Achi College of Nursing., Jose Ciby ,   Principal, Venkateshwara Nursing College Affiliated to The Tamil Nadu Dr. M.G.R. Medical University, Chennai, Tamil Nadu, India.
Published: May 2024

Background: The children with ADHD struggle to acquire extended behavioural sequences, especially when it comes to response location. Aim and objective: To assess the effectiveness of the caregiver mediated psychosocial intervention on behaviour and academic performance of the caregivers of children with ADHD. Materials and Methods: A quantitative approach with a quasi-experimental non-equivalent control group design was chosen for the study involving 30 caregivers who were selected using a non-probability purposive sampling technique. The paediatric symptom checklist and Du Pauls academic performance rating scale was used as the data collection tool. Results: It was revealed that in the experimental group 100% had maladaptive behaviour score in pretest and in post-test it was 66.67% had adaptive behaviour score. However, in control group 100.00% had maladaptive behaviourscore both in pretest and post-test. In experimental group 46.67% had poor academic performance score in pretest and in post-test 86.67% had good academic performance score. However, in control group 53.33% had poor academic performance score in pretest and in post-test 54.33% had poor academic performancescore. Conclusion: The study concluded that the caregiver mediated psychosocial intervention was effective in enhancing behaviour and increasing the academic performance of children with ADHD.
AUTOSOMAL RECESSIVE POLYCYSTIC KIDNEY DISEASE ABOUT A NEW CASE REPORT
Authors:   Gynecology and Obstetrics Department of Mohammed VI University Hospital, Oujda., Kamal El Harcha , Ayoub Aouragh ,   Gynecology and Obstetrics Department of Mohammed VI University Hospital, Oujda., Hafssa Taheri ,   Gynecology and Obstetrics Department of Mohammed VI University Hospital, Oujda., Hanane Saadi ,   Gynecology and Obstetrics Department of Mohammed VI University Hospital, Oujda., Ahmed Mimouni ,   Gynecology and Obstetrics Department of Mohammed VI University Hospital, Oujda.
Published: May 2024

We present the case of a 25-year-old woman gravida 2, para 01 who presented for childbirth at 40 weeks of gestation. Which Fetal Anatomy Ultrasound showed enlarged, hyperechoic fetal kidneys and a normal amniotic fluid index. Karyotyping was done on umbilical cord blood to look for mutations in the PKHD1 gene for the presumptive diagnosis of autosomal recessive polycystic kidney disease (ARPKD). In our patient, a previously reported pathogenic missense mutation in the PKHD1 gene, c.10444C>T, was found to be maternally inherited. A second previously unknown de novo mutation, c.5909-2delA, was discovered. This mutation is likely pathogenic because it affects the canonical splice site. Our case emphasizes PKHD1 allelic heterogeneity and the importance of prenatal genetic testing in a setting where many other genetic etiologies can phenocopy ARPKD.
CONTINUOUS SPINAL ANAESTHESIA FOR PROSTATICADENOMECTOMY IN PATIENT WITH SEVERE AORTIC STENOSIS
Authors:   Critical Care Unit, Provincial Hospital of Khenifra, Morocco., Amine Elhasnaoui M. , Bechri Brahim ,   Critical Care Unit, Hassan II Academic Hospital, Fes, Morocco.
Published: May 2024

Continuous spinal anesthesia is an interesting alternative in patients at high cardiac risk. We report the case of a patient who was scheduled to undergo prostatic adenomectomy. The pre-anesthetic consultation revealed a tight aortic stenosis. In the absence of therapeutic options at the aortic level, it was decided to operate this patient under continuous spinal anesthesia. This technique consists of placing a catheter intrathecally allowing the injection of a low dose of local anesthetic.our unit did not have a continuous spinal anesthesia kit, an epidural anesthesia kit was used as an alternative.
SECTIONS OF THE PROPHETS TURKS THEIR CAUSES AND LEGAL PURPOSES
Authors:   Senior Lecturer, Kulliyyah of Shariah & Law, Universiti Islam Antarabangsa Sultan Abdul Halim Muadzam Shah (UniSHAMS), 09300, Kuala Ketil, Kedah, Malaysia., Gomaa Gomaa Zaghloul Saad , Ramadan Mohmed Ahmed Harec Ahmed ,   Senior Lecturer, Kulliyyah of Shariah & Law, Universiti Islam Antarabangsa Sultan Abdul Halim Muadzam Shah (UniSHAMS), 09300, Kuala Ketil, Kedah, Malaysia., Aboumelih Mohamed Soliman Ragab ,   Associate Prof. Dr., Kulliyyah of Shariah & Law, Universiti Islam Antarabangsa Sultan Abdul Halim Muadzam Shah (UniSHAMS), 09300, Kuala Ketil, Kedah, Malaysia., Abous Maryam ,   Lecturer, Kulliyyah of Shariah & Law, Universiti Islam Antarabangsa Sultan Abdul Halim Muadzam Shah (UniSHAMS), 09300, Kuala Ketil, Kedah, Malaysia.
Published: May 2024

This research paper deals with the sections of the Prophets Turk of verbs, many of those who dealt with the issue of the Prophets Turks try to divide and branch the Turks in an attempt to drop the prohibition because of the Prophets Turks or drop the description of heresy on everything that is new, even if it has a legitimate rooting, and accordingly we try in the research paper to explain the sections of the Prophets Turks and their reasons to reach the legitimate truth of the Prophets Turks and their impact on the legal rulings and the purposes of the Prophets abandonment of the act , On the other hand, there are Prophetic Turks that came absolute without a reason, and accordingly the sections of the Prophets Turks can be explained as the reason or not into several sections, and the scholars have divided the Prophets Turks into several sections, and each section of them has its reasons to which the Prophets Turk is due, and these reasons are due to the fear of the hypothesis of work on Muslims. Such as skipping Taraweeh prayers in congregation in the mosque, or it may be that the abandonment is due to the unwillingness of the Prophet (peace and blessings of Allaah be upon him) to do so, such as not eating the meat of the dhab or similar taruk.
Virtual arbitration hearing: arbitrator's discretion or the right of the parties?
Authors: Kravtsov Serhii
Published: May 2024

Today, international commercial arbitration remains one of the most effective ways to resolve disputes complicated by a foreign element. Parties to a dispute, preferring arbitration, wish to obtain the desired result in the shortest possible time. This is achieved because the parties to the arbitration proceedings themselves are endowed with an arsenal of rights that are not inherent in national courts: the right to choose a particular arbitration, the composition of the arbitral tribunal, and the law to be applied in the dispute. This is a manifestation of the "autonomy of will" of the parties to the dispute. However, despite such a broad scope of powers, some powers of the arbitral tribunal, which is chosen by the parties, cannot be limited. Although the discretionary powers of international commercial arbitration are regulated by national arbitration laws and rules, their exercise may sometimes contradict the fundamental principles and standards of effective arbitration. One of such powers is the right to determine the format of arbitration hearings, since it is by exercising this right that the arbitral tribunal may make its own decision without taking into account the views of the parties to the dispute. The article provides a comparative legal analysis of arbitration legislation, rules and law enforcement practice of national courts with regard to the possibility of determining a virtual hearing as the most efficient format for consideration of a case. Particular attention is paid to the imperfection of Ukrainian legislative regulation and the lack of a single, consistent court practice on these issues.  Therefore, the conclusions propose to eliminate the shortcomings in the legal consolidation of such definitional constructs as "hearing" and "oral hearing".
Problems of legal regulation of thin capitalization in Ukraine
Authors: Pyroha Serhii
Published: May 2024

The proliferation of multinational companies is lengthening global value chains, and the development of the digital economy is giving them even more opportunities to shift profits. Intra-group loans are often used to shift profits to a jurisdiction with low tax rates to minimize overall tax liability. In order to combat the illegal transfer of profits, most countries introduce thin capitalization rules. Ukraine joined the BEPS plan, action 4 of which summarized the best practices for regulating debt obligations to non-residents. Most countries limit the total amount of loans, interest payments on which are deducted from the corporate tax base. The Tax Code of Ukraine establishes a double tax barrier - it limits both the amount of debt and the share of profit before deduction. However, the established barriers not only do not prevent profit shifting, but encourage the widespread use of this method to reduce tax liabilities due to profit shifting. The main drawback of thin capitalization rules is that allowed excessive amounts of loans from non-residents do not oblige the borrower to improve the financial results of the enterprise. Instead, they provide an opportunity to reduce the corporate tax base by 30% indefinitely and move them to jurisdictions with low tax rates. The method of regulation provided for by the Tax Code of Ukraine can be considered as an incentive for the misuse of State budget funds. In order to eliminate these shortcomings, it is proposed to significantly reduce both barriers and to oblige the borrower to ensure the effective use of loans to stimulate the socio-economic development of the country, i.e. to deduct interest from taxable profit only if there is an actual increase in the produced added value, the introduction of new products and/or processes. Existing shortcomings in the legal regulation of debt obligations prevent legal resolution of the case in court. New criteria for identification of the resident with regard to individuals and legal entities and the beneficial owner of income have been proposed.
Creation and Legal Status of a Specially Authorized Body of Non-Banking Financial Services
Authors: Bakalinska Olga , Shovkoplias Hanna
Published: May 2024

The article is devoted to the peculiarities of state regulation in the market of non-banking financial services. At the same time, attention was paid to the creation of a specially authorized state body in the form of the National Commission for Control of the Market of Non-Banking Financial Services. The purpose of the article is to reveal the legal status, the order of formation, and clarify the main principles of the National Commission's activity. Achieving the outlined goal became possible thanks to the use of a complex of methods of scientific knowledge, in particular, the dialectical method (for comprehensive knowledge of the nature of the National Commission for Control over the Market of Non-Banking Financial Services), the formal-legal method (for establishing the content of legal norms), the formal-logical method (for identification of shortcomings in national legal regulation), comparative legal method (for studying the experience of other countries and determining the prospects for implementing their principles of activity in the national legal field). It has been studied that the special status of the commission is that it ensures the stability of the entire non-banking financial system of Ukraine, establishing the requirements that such institutions must meet, namely requirements for: liquidity, solvency, capital, asset quality, risk level of operations, profitability. The work examines the relationship between the commission and the National Bank of Ukraine, their cooperation in the market, which consists in the development of regulatory and legal acts and their approval. The need for the National Bank of Ukraine to delegate its powers to the National Commission for Control of Non-Banking Financial Services in relation to: registration of market participants, licensing of non-bank financial institutions, determining the procedure for issuing and canceling a license, approving the terms of operation of such institutions. In view of this, a new model of state regulation on the market of non-banking financial services was proposed in the form of concentration of all control functions on the market in a single operationally independent regulator - the National Commission for Control of Non-Banking Financial Services, which is in close cooperation with the National Bank of Ukraine and by the National Securities and Stock Market Commission. Also, the article emphasizes that regulation by the National Commission for Control of the Market of Non-Banking Financial Services should be complemented by a system of self-regulating participants in the market, which are an additional tool to state regulation.
Synthesis, utilization, and recycling of graphene oxide-based nanohybrid biopolymeric hydrogels for purification of dye wastewater
Authors: Sarwar Omera , Munir Ruba , Mushtaq Nageen , Ambreen Hina , Bashir Muhammad Zeeshan , Sana Maryam , Muneer Amna , Sayed Murtaza , Noreen Saima
Published: May 2024

Wastewater from industries contributes significantly to pollution. Adsorption of acidic dye using nanohybrid biopolymeric hydrogels has evolved as one of the viable techniques. Graphene oxide (GO)/chitosan (CS)–polyvinyl alcohol (PVA), GO/starch–PVA, and GO/agar–PVA hydrogels were synthesized. The results revealed that the following are the ideal values: GO/CS–PVA: 3 pH (8.251 mg g−1), 0.05 g/50mL dosage (8.251 mg g−1), 90 min (8.251 mg g−1), 12 ppm dye concentration (8.251 mg g−1), and 30 °C (8.251 mg g−1); for GO/starch–PVA: 2 pH (7.437 mg g−1), 0.05 g/50 mL dosage (7.437 mg g−1), 90 min (7.437 mg g−1), 12 ppm dye concentration (7.437 mg g−1), and 30 °C (7.437 mg g−1); and for GO/agar–PVA; 3 pH (6.142 mg g−1), 0.05 g/50 mL dosage (6.142 mg g−1), 90 min (6.142 mg g−1), 12 ppm dye concentration (6.142 mg g−1), 30 °C (6.142 mg g−1). GO/CS–PVA outperformed the other hydrogels. The Langmuir model suited GO/CS–PVA data, while GO/starch–PVA and GO/agar–PVA hydrogels followed Freundlich isotherm models. The adsorption capacity data followed a pseudo-second-order model. Negative value of Gibbs free energy and enthalpy showed that the reactions were spontaneous and exothermic in nature. The presence of heavy metals, electrolytes, and detergents/surfactants affected the dye adsorption. Entropy changes positive values implied randomness at the solid/solution contact. The desorption (60, 55, and 58%) of GO/CS–PVA, GO/starch–PVA, and GO/agar–PVA hydrogels was obtained using 0.5 N NaOH. Scanning electron microscope, X-ray diffraction, and Fourier transform infrared (FT-IR) were used for characterization.