bluuebunny/crossref_metadata_2025 huggingface dataset:
Percepción del rol del periodista latinoamericano en contextos de conflicto, violencia y conmoción social
Authors: Tusa Jumbo Fernanda Esperanza , Tejedor Santiago
Published: July 2023

Esta investigación analiza la percepción de los profesionales de la información, la comunicación y el periodismo de la región latinoamericana sobre el rol que cumplen en contextos de conflicto, violencia y conmoción social. Para ello se aplica una metodología cualitativa a través de la técnica de la entrevista estructurada dirigida a 26 profesionales de 10 países, quienes voluntariamente accedieron a colaborar en el estudio, constituyéndose en una muestra no probabilística por conveniencia. Entre los resultados se advierte, entre otros datos, una violencia simbólica contra el ejercicio del periodismo en la región latinoamericana, más aún, en países donde la institucionalidad tiene flancos de vulnerabilidad acentuados y adolece de libertad de expresión. Al respecto, las fuentes consultadas puntualizan que en algún momento han sido víctimas de diversas formas de intimidación durante sus coberturas, especialmente, en países donde se ha normalizado la discriminación y la cultura de la impunidad. A más de ello refieren haber sufrido acoso y hostigamiento en su entorno laboral. Al término del estudio se advierte que los periodistas perciben su rol como vigilantes, en términos de cuestionar y actuar como fiscalizadores de los poderes fácticos. De hecho, se autoperciben a nivel profesional con el deber de elevar la conciencia social y romper el estatus quo para atacar las raíces de los problemas sociales de sus respectivos países. Se menciona la importancia de evitar el paternalismo y la condescendencia hacia los gobiernos y las autoridades. El estudio concluye que estos profesionales respaldan la pertinencia de un compromiso con la sociedad civil y los sectores más vulnerables en miras a la construcción colectiva de una mejor democracia.
Prêts d'amitié et prêts à intérêts à Athènes à l'époque classique.
Authors: Aka Adou Marcel
Published: July 2023

Athènes connut à l’époque classique le développement des prêts contractés entre particuliers. Ceux-ci recoururent soit aux prêts d’amitié (les ἔρανοι) soit aux prêts à intérêts (les δάνεια). Ces deux types de prêts se contractaient selon des conditions différentes et survinrent à des occasions où des citoyens ressentaient un besoin urgent d’argent. Ils permettent de constater qu’à Athènes une solidarité à grande échelle s’était développée entre des membres d’une même classe, d’un même milieu d’affaire ou des personnes ayant des relations amantes.
A Drosophila melanogaster Ref(2)P LC3- interakciós régió mutációjának hatása az oxidatív stresszre
Authors: Ürmösi Adél
Published: July 2023

Az autofágia a sejtek evolúciósan konzervált intracelluláris degradációs folyamata. A fő útvonala során a citoplazmatikus anyag lebontása a lizoszómális rendszeren keresztül történik. A szelektív autofágia receptorok képesek felismerni az poliubiquitinálódott aggregátumokat és kötődni az Atg8/LC3 fehérjéhez, hogy biztosítsák az aggregátumok jelenlétét az autofagoszómába. A Drosophila-ban a legismertebb autofágia receptor, amihez az ubiquitinált fehérje aggregátumok kapcsolódnak az általunk is vizsgált p62/Ref(2)P. A Ref(2)P-ben található egy C-terminális ubiquitin-kötő domén (UBA), egy N-terminális PB1 domén, amely közvetíti az aggregátumok képződését és egy LIR (LC3- interakciós régió) motívum, egy strukturálatlan régióban, ami felel az LC3/Atg8a–val való kötődésért az autofág membránon. PhD munkám során a Ref(2)PLIR motívumában CRISPR/Cas9 közvetítette homológ rekombinációval létrehoztunk két aminosavcserét, ahol egy triptofánt és egy izoleucint alaninra cseréltünk. Így létrehoztunk egy Drosophila törzset, amely hordozza ezt a LIR mutációt, amely megszünteti a Ref(2)P-Atg8a kapcsolatát. Összefoglalásul elmondhatjuk, hogy sikeresen létrehoztunk egy Ref(2)PLIR mutáns törzset. Ezek az állatok nagy számban felhalmozzák a Ref(2)P-t és az ubiquitinált fehérjéket. Az általunk megfigyelt ubiquitin aggregátumok ubiquitinálódott Keap1-et tartalmaznak, amely az Nrf2 függő oxidatív stressz válasz negatív szabályozója. A Keap1 autofág lebontása a Ref(2)P LIR doménjén keresztül történik, így létrehozva az Atg8a-Ref(2)P-Keap1 komplexet, ami elősegíti a képződő aggregátumok degradálódását. Ezáltal az emlősökhöz hasonlóan a szabad Keap1 szint és az Nrf2 aktivitás a Ref(2)P által szabályozott. A Ref(2)P-Keap1 együttes szekvesztrálásának fontos következménye a LIR mutánsban a tartósan megnövekedett Nrf2 aktivitás, mivel annak proteaszómális lebomlását a mutáns Ref(2)P megakadályozza, ami végső soron megnövekedett PQ toleranciához vezet. Megfigyeltük, hogy a folyamatos Nrf2 aktivitás a Ref(2)PLIR mutáns állatokban fiziológiai előnyökkel jár a vad típushoz képest. A kísérleti adatainkból létrehozott modell szerint az ubiquitinálódott aggregátumok szekvesztrálódása először megemeli a proteotoxicitást. Azonban ezután az Nrf2 által vezérelt megnövekedett detoxifikáció csökkenti az oxidált, majd ubiquitinálódott fehérjék számát, amelyek oldható formában találhatóak és valószínűleg sokkal toxikusabbak. A szelektív ubiquitinált fehérje-autofágia hibás ecetmuslicák hasonló mennyiségű poliubiquitin aggregátumot halmoznak föl, mint az Atg mutánsok, de nem mutatnak jelentősebb fiziológiai hibákat.
Monitoring of anatomical changes during adaptive brain radiotherapy in glioma patients
Authors: Darázs Barbara
Published: July 2023

Célkitűzés: Megvizsgáltuk a laterális kamrák (LV-k) és a szubventrikuláris zónák (SVZ-k) anatómiai helyzetét, valamint ezek alakjában és térfogatában bekövetkezett változások mértékét. Más kritikus rizikószerveket is bevontunk a vizsgálatba, hogy meghatározzuk az újratervezés milyen módon határozza meg a leadott dózist. Ezenkívül az SVZ sugárdózisa és a klinikai kimenetel közötti összefüggést elemeztük a medián SVZ dózis küszöbértékével számolva mind az első tervezési CT-n meghatározott struktúrákra, mind a megváltozott azonos és ellenoldali SVZ-k adataira az ismételt CT vizsgálaton. Módszerek: Elemeztük az azonos oldali/ellenoldali LV és SVZ, valamint a többi OAR-k anatómiai változásait. Mindkét tervezési CT felvételen (primer CT1 és másodlagos CT2) értékeltük a térfogati és dozimetriai változásokat. A glioblastoma multiforme (GBM) betegek túlélését Kaplan–Meier módszerrel és többváltozós Cox-regresszióval vizsgáltuk. Eredmények: Jelentős térfogati változásokat figyeltünk meg az LK-k és SVZ-k esetén a CT2-n, ami a dózislefedettség növekedését eredményezte. 58 Gy elvágási értéknél szignifikáns korrelációt észleltünk az iSVZ2 átlagos dózisa és a teljes túlélés (OS) között (27.8 vs 15.6 hónap, p=0.048). Többváltozós elemzésben azoknál a GBM-betegeknél, akiknél rövidebb volt a műtét-posztoperatív kemoradioterápia időintervalluma (<3.8 hét), jó általános állapotúak (≥70%) és magasabb átlagos iSVZ2 dózist (≥58 Gy) kaptak, szignifikánsan jobb volt az OS. Megállapítottuk, hogy a rizikószervek minden vizsgált dózisparaméterének átlaga alacsonyabb volt, mint a CT1-nél és az újratervezésnél számított értékkel összehasonlítva a legtöbb esetben szignifikáns eltéréseket okozott. Következtetések: Az agyi struktúrákban jelentős anatómiai és dóziseloszlási változásokat figyeltünk meg, amelyek hatással vannak a GBM későbbi kimenetelére. Ezért érdemes megfontolni az iSVZ bevonását a céltérfogatba, és a sugártervezés során figyelembe venni ezeket a változásokat.
Gyógyszer- és természetes hatóanyagok védőhatásának vizsgálata vér-agy gát károsodással szemben tenyészetes modellen
Authors: Barna Lilla
Published: July 2023

Számos betegséghez társul szisztémás és idegrendszeri gyulladás. Ezekben a felszabaduló citokinek és az excitotoxinok vér-agy gát károsodást hoznak létre, ami tovább súlyosbítja a neuroinflammációt. Ennek megakadályozása a gátrendszer védelmével fontos feladat ezeknek a gyulladásos betegségeknek a gyógyításában. Mivel a gyulladással is járó központi idegrendszeri betegségek kezelése még nem megoldott, ezért a kiegészítő kezelések és új szerek feltárása fontos és aktuális kutatási terület. Vizsgálataink során az excitotoxikus kainát, valamint a TNF-α és az IL-1β gyulladásos citokinek által okozott károsodások kivédésére gyógyszerhatóanyagok és természetes vegyületek agyi endotélsejtekre kifejtett hatását tanulmányoztuk. Kísérleteinkben igazoltuk a kainát receptorok jelenlétét tenyésztett primer agyi endotélsejteken és izolált agyi mikroér frakcióban. Először mutattuk ki, hogy az excitotoxin kainát közvetlenül károsítja az agyi endotélsejteket. Kainsav kezelés hatására a TJ fehérjék festődési mintázata szakadozottá vált a sejthatárokon, ami a vér-agy gát megnyílására utalt. A kainát megnövelte a jelzőanyagok átjutását a barrieren, valamint az NO termelődését és a NOS2/iNOS mRNS expresszióját agyi endotélsejteken. A szimvasztatin, edaravon és dexametazon védőhatást mutatott a kainsav által csökkentett életképesség, megnövelt jelzőanyag átjutás és a sejtek közötti kapcsolatok immunfestésében mért változások ellen tenyészetes vér-agy gát modellen. Ezen felül a dexametazon kivédte a kainsav kezelés által fokozott NO termelődést és NOS2/iNOS expressziót. Tenyészetes agyi endotélsejteken és vér-agy gát modellen kapott eredményeinkkel alátámasztottuk a természetes szőlő hatóanyagok antioxidáns és gyulladáscsökkentő hatását vaszkuláris endotélsejteken. Ezek az eredmények összhangban állnak a szőlő kivonatok hagyományos felhasználásával és a bioaktív szőlő vegyületekkel végzett klinikai vizsgálatokkal szív- és érrendszeri megbetegedésekben. Adataink alapján a GSPE és a szőlő fenolos vegyületek a vér-agy gátra kifejtett jótékony hatásuk révén fontos elemei lehetnek a krónikus elhízás kezelésének. A vizsgált természetes hatóanyagok részben gátolni tudták a citokinek által kiváltott gyulladást, ami fontos eleme az elhízás patológiájának. Agyi endotélsejt tenyészeteken végzett kísérleteink rávilágítottak arra, hogy a szőlőből származó természetes vegyületek milyen mechanizmusok révén állhatnak kapcsolatban a leptin transzportjával. Eredményeink felhívják a figyelmet a természetes vegyületek lehetséges jótékony hatására élelmiszerek vagy táplálékkiegészítők összetevőjeként. Mindezek az eredmények megerősítik a természetes vegyületek és a klinikumban már használt gyógyszerhatóanyagok a vér-agy gátra kifejtett protektív hatását.
Relação entre a Capacidade Social e o Desempenho Social das Empresas Brasileiras Mediada pela Responsabilidade Social Corporativa
Authors: Leão de Miranda Ronaldo , Regina dos Santos Parisotto Iara
Published: July 2023

Objetivo: Este estudo objetiva analisar a relação entre a capacidade social e o desempenho social, mediada pela responsabilidade social corporativa, no contexto das empresas brasileiras listadas na B3.
Método: A pesquisa caracteriza-se como descritiva em relação a seu objetivo, quanto aos procedimentos é considerada como pesquisa aplicada a partir do levantamento de dados primários. Este estudo foi realizado com empresas de capital aberto do Brasil, por meio da aplicação de questionário aos gestores das empresas listadas na B3. As respostas obtidas por meio do questionário são provenientes da alta administração. Trata-se de uma pesquisa quantitativa em relação à abordagem do problema, sendo analisada por meio da modelagem de equações estruturais (MEE), com utilização do software SPSS AMOS versão 22.
Resultados: A importância da capacidade social não é apenas uma consideração estratégica para obter bons resultados de desempenho social e RSC, é antes de tudo uma consideração primária e fundamental quando se trata do alcance dos objetivos sociais das empresas. Diante disso, este estudo comprova que existe uma relação entre a capacidade social e o desempenho social das empresas brasileiras mediada pela responsabilidade social corporativa. Esse caminho de mediação CS => RSC => DS possui um ß= 0,705, onde a CS e RSC explicam o DS em aproximadamente 93%.
Contribuições: O estudo contribuiu à medida que esclarece, no teste de mediação, que a responsabilidade social corporativa medeia positivamente a relação entre a capacidade social e o desempenho social das empresas brasileiras. Somente integrar as partes interessadas nos processos decisórios e incluir suas necessidades na definição e realização dos objetivos sociais da organização não são suficientes para atender aos interesses de suas partes interessadas. Como implicação prática, as evidências da pesquisa empírica podem contribuir para elucidar discussões sobre a capacidade social auxiliar os gestores e diretores das empresas brasileiras a entender melhor o seu papel na distribuição de bens não financeiros.
On a point kinetic with explicit presence of neutron poisons: reactivity decomposition according to long time scales
Authors: Espinosa Carlos Eduardo , Fernandes Julio Cesar Lombaldo
Published: July 2023

The present work consists of deducing the point kinetics model considering neutron absorber poisons from the neutron diffusion equation. When considering poisons products, the non-linear system has different orders of magnitude in short and long time scales. The first one represents operational reactor control, whereas the second is due to the change of the chemical composition of the nuclear fuel as a result of burn-up. This represents a first step in a new direction, as it shows how we arrived at the extension of the point kinetics model considering Xenon-135 and Samarium-149 poisons. The non-linear system is solved using the Adomian decomposition method that expands the non-linear terms into an infinite series, obtaining a recursive system, where the recursion initialization is a homogeneous linear equation and the subsequent recursion steps consider the non-linear contributions as source terms constructed from previous recursion steps. The formulation of the source terms of the decomposition method is shown. In order to demonstrate the robustness of the current approach to this type of problem, case studies are presented where nuclear fuel uses reused elements up to third generation, taking a step in a new direction where poisons are already present in the reactor initially.
La fallida tasa por instalación de ventanillas o tornos en las farmacias: no todo es aprovechamiento especial del dominio público
Authors: Mories Jiménez María Teresa
Published: July 2023

Ante la pretensión de exigir por el Ayuntamiento de Aspe (Alicante) una nueva tasa por aprovechamiento especial del dominio público por los dispositivos de atención situados en las farmacias en línea de fachada y acceso desde el exterior, el Tribunal Supremo rechaza la existencia de un aprovechamiento especial del dominio público al considerar que, dadas las especiales características de la atención farmacéutica, no se produce la eventual intensidad del uso del dominio público ni un beneficio particular asociado al mismo, por lo que no resulta aplicable en este supuesto la jurisprudencia relativa a la tasa por cajeros automáticos.
APAKAH AKU MASIH MEMILIKI HARAPAN? STUDI KUALITATIF FENOMENOLOGI PENGALAMAN IBU KORBAN KDRT HINGGA MEMUTUSKAN BERCERAI
Authors: Rachmatunisa Nadya Ridha , Rahmandani Amalia
Published: July 2023

Setiap orang mendambakan pernikahan yang harmonis. Namun, terdapat pernikahan yang mengalami kekerasan dalam rumah tangga (KDRT) sehingga menimbulkan dilema bagi ibu antara memilih untuk mempertahankan rumah tangganya atau bercerai. Tujuan penelitian ini  untuk mengetahui pengalaman ibu korban KDRT hingga memutuskan bercerai. Subjek penelitian berjumlah 3 orang dengan menggunakan teknik purposive sampling berdasarkan  kriteria seorang ibu yang memiliki anak, telah bercerai setidaknya minimal 2 tahun mengalami KDRT khususnya jenis KDRT psikis karena perselingkuhan, dan bersedia menjadi partisipan penelitian. Metode dalam penelitian ini ialah metode kualitatif  dengan pendekatan Interpretative Phenomenological Analysis (IPA) melalui wawancara semi terstruktur. Hasil penelitian diperoleh tiga tema induk, yakni (1) tema terkait dinamika ketika mengalami KDRT meliputi tema superordinat dampak akibat KDRT dan jenis KDRT yang dialami; (2)  pengambilan keputusan bercerai meliputi tema superordinat , pertimbangan pengambilan keputusan cerai, upaya mempertahankan rumah tangga, persiapan menghadapi perceraian; dan (3) pengasuhan anak meliputi tema superordinat upaya memahami anak, strategi pengasuhan anak, dan  makna anak bagi ibu. Berdasarkan tema-tema tersebut dapat diambil kesimpulan fenomena pengambilan keputusan cerai cenderung menyebabkan beban psikologis bagi ibu dan anak. Tetapi ternyata peristiwa itu tidak selamanya negatif apabila merupakan satu-satunya pilihan bagi keluarga yang mengalami kekerasan dalam rumah tangga yang berkepanjangan. Pengambilan keputusan cerai tidak terlepas dari faktor-faktor yang memengaruhinya yaitu adanya penderitaan selama mengalami KDRT, adanya dukungan sosial dan mempertimbangkan kondisi psikologis anak.
Penentuan Tipologi Halte BRT Trans Jateng Koridor I di Kabupaten Semarang Berdasarkan Konsep Transit Oriented Development
Authors: Pramono Arsyad Hadi
Published: July 2023

Pembangunan metropolitan di Kota Semarang menjadi pemicu tingginya fenomena urbanisasi dan urban sprawl di kawasan pinggiran, diantaranya Kabupaten Semarang. Hal itu berdampak pada permasalahan sistem transportasi yang berperan penting dalam pertumbuhan kota. Dibutuhkan pergeseran strategi yang lebih inovatif dengan penerapan konsep Transit Oriented Development (TOD). Beroperasinya Bus Rapid Trans (BRT) Trans Jateng koridor I Semarang Tawang-Terminal Bawen dapat menjadi embrio bagi Provinsi Jawa Tengah dalam menerapkan konsep TOD. Halte BRT sebagai titik transit berpotensi dikembangkan berdasarkan konsep TOD sebagai upaya penataan sistem transportasi yang terintegrasi dengan kawasan disekitarnya. Terdapat 29 halte di Kabupaten Semarang di sepanjang jalan arteri Ungaran-Bawen yang menjadi objek penelitian. Tujuan penelitian ini adalah menenetukan tipologi halte BRT Trans Jateng Koridor I di Kabupaten Semarang berdasarkan konsep TOD. Penelitian ini menggunakan analisis buffering dan analisis cluster. Variabel yang digunakan adalah kepadatan permukiman dan proporsi tutupan lahan (density), jenis guna lahan dan proporsi permukiman-non permukiman (diversity), serta ketersediaan jalur pejalan kaki dan konektivitas jaringan jalan (design). Dari hasil analisis diketahui 3 tipologi TOD, yaitu 16 halte sebagai TOD kota, 8 halte sebagai TOD sub kota, dan 5 halte sebagai TOD lingkungan.
Antigen Presentation and Proteome Study of Exosomes Secreted by Co-Culture of Macrophages and Talaromyces marneffei
Authors: Xie Zhi , Li L. L. , Wei G. J. , Wang C. , Zhang D. H. , Wei L.
Published: July 2023

It is known that intracellular pathogens interact and react with the cellular immune system through exosomes produced by macrophages. This study aimed to determine whether co-culture of macrophages and Talaromyces marneffei induces exosomes and leads to immune responses. T. marneffei was incubated to collect conidia, co-cultured with human macrophages, which then induced exosomes. In cellular experiments, after extraction and purification, the exosomes were then observed by electron microscopy and detected by flow cytometry and mass spectrometry. In animal experiments, flow cytometry and enzyme-linked immunosorbent assay were used to examine whether exosomes were antigen-presenting. The results showed that purified exosomes produced a pro-inflammatory response and stimulated production of TNF-α in non-fungal-treated macrophages. Protein mass spectrometry analysis of exosomes also indicated their potential ability to activate the internal immune response system and the pro-inflammatory response. Translation and ribosomes were the most abundant GO terms in proteins, and the most relevant KEGG pathway was the biosynthesis of secondary metabolites. Furthermore, in vivo experiments revealed that exosomes induced activation of lymphocytes and increased expression of TNF-α and IL-12 in the lung, mediastinum, and spleen area. In conclusion, exosomes can be released by co-culture of T. marneffei and macrophages, having antigen-presenting functions, promoting macrophage inflammation, and initiating adaptive immune responses. These processes are inextricably linked to the translation of secondary metabolites, ribosomes and biosynthesis.
Limonitum Ameliorates Castor Oil-Induced Diarrhoea in Mice by Modulating Gut Microbiota
Authors: Ma Y. L. , Yan B. F. , Liu Shengjin , Dai S. L. , Liu J. , Wang X. X. , Fang F. , Wu S. C. , Wang Y. , Xu C. Y. , Zhao Q. , Wang H. B. , Wu Dekang
Published: July 2023

Diarrhoea is a common clinical condition; its pathogenesis is strongly associated with gut microbiota dysbiosis. Limonitum is a well-known traditional Chinese medicine that exerts appreciable benefits regarding the amelioration of diarrhoea. However, the mechanism through which Limonitum ameliorates diarrhoea remains unclear. Here, the efficacy and underlying mechanism of Limonitum decoction (LD) regarding diarrhoea were explored from the aspect of gut microbiota. Castor oil (CO) was used to induce diarrhoea in mice, which were then used to evaluate the effects of LD regarding the timing of the first defecation, diarrhoea stool rate, degree of diarrhoea, diarrhoea score, intestinal propulsive rate, and weight of intestinal contents. The concentrations of short-chain fatty acids (SCFAs), including acetic, propionic, isobutyric, butyric and valeric acids, were analysed by gas chromatography-mass spectrometry (GC-MS). The 16S rRNA high-throughput sequencing technology was applied to evaluate changes in the gut microbiota under exposure to LD. LD was found to effectively ameliorate the symptoms of diarrhoea, and the diversity and relative abundance of gut microbiota were restored to normal levels following LD treatment. Additionally, LD significantly restored the observed reductions in SCFAs. These results provide strong evidence that LD can sufficiently ameliorate diarrhoea in mice by regulating their gut microbiota. The findings presented here highlight that Limonitum may constitute a prospective remedy for diarrhoea.
The declarative–procedural knowledge of grammatical functions in higher education ESL contexts: Fiction and reality
Authors: Abu-Ayyash Emad A. S. , Hamam Doaa
Published: July 2023

The present article purported to gain insights about English as a second language (ESL) learners’ knowledge of grammatical functions at the declarative and the procedural levels in the higher education context, and argued that the dialogue between the types of knowledge calls for more attention. The study utilised a Words-in-Sentences Test that was administered to 841 ESL students in seven colleges and universities in three Arab countries: United Arab Emirates, Jordan and Oman. The test was used to measure the participants’ declarative knowledge of grammatical functions. The participants’ test scores were then correlated with their essay writing scores to find if there is a significant correlation between the two, and thus gain insight into the relationship between the declarative knowledge and the procedural knowledge of grammatical functions. Finally, a qualitative analysis was conducted on nine essays to gain an in-depth understanding of this relationship. The findings indicated that the university participants’ declarative knowledge of grammatical functions was below the expected level and that there was a significant correlation between the learners’ test scores and writing scores. In addition, intriguing themes emerged from the qualitative analysis. Together, the findings are anticipated to spark more research on grammatical function knowledge among university students in ESL contexts.
Green removal of low and high levels of Cu(II) and Cr(III) cations from concentrated saline chloride medium achieved by a mixture of N,N′-bis(salicylidene)-thiocarbohydrazide-TritonX-100 micellar system via cloud point extraction process
Authors: Khiat Meriem , Reffas Hasnia , Hadj Youcef Mohammed , Benabdallah Tayeb
Published: July 2023

In this work, we performed the cloud point extraction with low and high concentrations of Cu(II) and Cr(III), two particularly toxic metallic pollutants, that have been shown to have adverse effects on human health and the environment. Removal of the metal ions was achieved in the presence of Triton X-100 as a non-ionic surfactant and N,N′-bis(salicylidene)-thiocarbohydrazide as a chelating ligand in concentrated chloride medium. The behavior of the Schiff base was initially investigated in homogeneous DMSO-water and micellar Triton X-100-water media. The obtained values of the acid constants show that the extractant is more acidic in micellar media than in pure aqueous medium. The recorded cloud point temperatures of Triton X-100 are significantly impacted by the sodium chloride concentration, the surfactant concentration, and the Schiff base ligand. Under the optimised experimental conditions, a quantitative extraction of Cu(II) and a maximum extraction rate of 74 % of Cr(III) were obtained. The reduction of the metal concentration from 10−3 mol L−1 to 10−6 mol L−1 resulted in a reduction of the temperature by 10 °C and a reduction of the contact time from 10 h to 3 h.
How should job displacement wage losses be insured?
Authors:   George Washington University, Parsons Donald O.
Published: July 2023

Job displacement represents a serious earnings risk to long-tenured workers through lower re-employment wages, and these losses may persist for many years. Moreover, this risk is often poorly insured, although not for a lack of policy interest. To reduce this risk, most countries mandate scheduled wage insurance (severance pay), although it is provided only voluntarily in others, including the US. Actual-loss wage insurance is uncommon, although perceived difficulties may be overplayed. Both approaches offer the hope of greater consumption smoothing, with actual-loss plans carrying greater promise, but more uncertainty, of success.
Global Infectious Diseases in June 2023: Monthly Analysis
Authors: Zhang Shuqiong , Fu Xin , He Shiping , Zou Jiazhen , Luo Yi , Li Guodan , Xiang Qi , Li Taihan , Gu Dayong , Su Qun , He Minjing , Yu Wenjin
Published: July 2023

Infectious diseases are a class of diseases caused by various pathogens that can be transmitted between humans and animals or between humans and animals, thus seriously affecting the development of human society. To control the spread of infectious diseases worldwide and ensure the safety of people’s lives, it is essential to regularly analyze global infectious disease cases. This review is based on data from the World Health Organization, the Centers for Disease Control in countries around the world, Outbreak News Today and many other epidemiological websites to predict the global infectious disease outbreak trend. In addition, using the Shuci Technology global epidemic information monitoring system, we analyzed the distribution of infectious diseases that occurred around the world from 24 May 2023 to 23 June 2023.
UBQLN2 and HSP70 participate in Parkin‐mediated mitophagy by facilitating outer mitochondrial membrane rupture
Authors: Ma Qilian , Xin Jiaqi , Peng Qiang , Li Ningning , Sun Shan , Hou Hongyu , Ma Guoqiang , Wang Nana , Zhang Li , Tam Kin Yip , Dussmann Heiko , Prehn Jochen HM , Wang Hongfeng , Ying Zheng
Published: July 2023

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two aging‐related neurodegenerative diseases that share common key features, including aggregation of pathogenic proteins, dysfunction of mitochondria, and impairment of autophagy. Mutations in ubiquilin 2 (UBQLN2), a shuttle protein in the ubiquitin‐proteasome system (UPS), can cause ALS/FTD, but the mechanism underlying UBQLN2‐mediated pathogenesis is still uncertain. Recent studies indicate that mitophagy, a selective form of autophagy which is crucial for mitochondrial quality control, is tightly associated with neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and ALS. In this study, we show that after Parkin‐dependent ubiquitination of damaged mitochondria, UBQLN2 is recruited to poly‐ubiquitinated mitochondria through the UBA domain. UBQLN2 cooperates with the chaperone HSP70 to promote UPS‐driven degradation of outer mitochondrial membrane (OMM) proteins. The resulting rupture of the OMM triggers the autophagosomal recognition of the inner mitochondrial membrane receptor PHB2. UBQLN2 is required for Parkin‐mediated mitophagy and neuronal survival upon mitochondrial damage, and the ALS/FTD pathogenic mutations in UBQLN2 impair mitophagy in primary cultured neurons. Taken together, our findings link dysfunctional mitophagy to UBQLN2‐mediated neurodegeneration.
Teachers as Researchers: An Emphasis on the Readiness and Attitude towards Action Research
Authors: Jr Leo L. Codilla, , Barot Hannah Yangson-
Published: July 2023

This study explored the readiness and attitude of teachers in conducting action research. Specifically, the study aimed to determine the profile of the teachers, the level of the participants' research readiness, the extent of the participant's attitude toward action research, and the factors that hinder the participants in conducting action research. The study employed a descriptive-correlational research design. Frequency counts, percentages, weighted mean, one-way ANOVA, and Pearson product-moment correlation were used in the study. Results revealed that the participants had a relatively high level of education and experience in teaching, but their research involvement was limited. The participants were motivated to conduct action research, but their research literacy and analysis skills needed improvement. In addition, the study highlighted the need for support from various stakeholders to equip teachers with the necessary knowledge and skills to conduct action research effectively. The hindering factors to conducting action research were overburdened work schedules, lack of fundamental skills, and inadequate training and experience. Several factors, including research outlook, research interest, research benefit, research motivation, research literacy, research support, and research analysis and interpretation, were found to have a strong positive correlation with research readiness. It is recommended that teachers may be provided more training, support, and resources for them to increase their research involvement and strengthen their readiness and positive attitude toward action research.
Education in Times of Pandemic a New Normal from Teaching Practice
Authors: Casco Roque Juan Espinoza- , Espinoza Jair Omar Alvarado- , Quispe Crystal Massiel del Carmen Reyna- , Quezada Pedro Ricardo Quiroz- , Castañeda Elena Esther Yaya , Mejía Percy Junior Castro-
Published: July 2023

To explore the repercussions of virtual education from teaching practice. The approach used is the qualitative systematic bibliographic review; consulting academic literature. There are numerous coincidences that teachers faced in the context of the health emergency, the need for self-training, lack of digital skills and emotional conditions. The new normal conditions a more digital education trend, it is time for a new transition where technology must be incorporated into the Peruvian school as a necessary tool for the learning process.
Upaya Unit Kearsipan I Kementerian Perdagangan Menuju Efektivitas Penyusutan Rekod Inaktif
Authors: Barkahry Lulu Cherly , Irfaniah Hikmah
Published: July 2023

Penyusutan arsip merupakan kegiatan pengendalian arsip yang efektif dalam pengelolaan arsip. Tujuan penelitian ini adalah untuk mendeskripsikan proses penyusutan dan upaya yang dilakukan dalam mewujudkan efektivitas penyusutan arsip di Pusat Arsip I Kemendag RI. Penelitian ini menggunakan pendekatan kualitatif dan metode studi kasus. Hasil penelitian menunjukkan bahwa proses penyusutan terdiri pemusnahan arsip yang tidak bernilai dengan menggunakan jasa pihak ketiga dan penyerahan arsip yang memiliki nilai berkelanjutan ke Arsip Nasional Republik Indonesia (ANRI). Unit Kearsipan I telah berupaya untuk mencapai efektivitas penyusutan arsip melalui penetapan tujuan, integrasi, dan adaptasi. Penetapan tujuan dilakukan melalui penetapan jadwal penyusutan arsip; integrasi dilakukan dengan melaksanakan pembagian kerja untuk mendukung pelaksanaan penyusutan arsip yang maksimal, dan adaptasi dilakukan dengan menyesuaikan dengan perubahan terkait sarana dan prasarana. Penelitian ini memberikan gambaran tentang bagaimana pelaksanaan penyusutan arsip dan rangkaian upaya yang dapat dilakukan lembaga arsip untuk mencapai efektivitas penyusutan arsip
The Principles of Islamic Communication on Reference Services at the Indonesian Trade Training Center Library
Authors: Maylaffayza Hilya , Wanastri Prisinta
Published: July 2023

Communication is the thing that can be separated from library activities. All library services rely on communication to interact with their users, especially reference services. Communication in reference services is personal, so the application of interpersonal communication skills must be owned by the reference librarian. Interpersonal communication is regulated and exemplified in Islam, with the Qur'an and Hadith. In the library environment, the principles of Islamic communication can certainly be applied by the librarian. This paper discusses applying Islamic communication principles to referral services at the Trade Training Center Library, Ministry of Trade of the Republic of Indonesia. The qualitative method with a case study approach is carried out in the research, where the data was collected by interviewing librarians and users in the library. This study shows that the librarian of the reference service to the users at the Library of the Trade Training Center of the Republic of Indonesia applies the principles of Islamic communication in interacting with users, which include: qaulan sadidan (speaking honestly), qaulan baligha (speaking clearly), qaulan ma'rufa (talking with wise), qaulan karma (speaking with noble words), qaulan layyina (speaking gently), and qaulan maysura (speaking politely). In addition, librarians are also able to uphold the principles of ukhuwah islamiyah (creating good relations with users), tabbayun (always cross-checking on developing information), and also fastabiqul khairat (inviting staff and users to compete for goodness).
Information Seeking Behavior of the Authors Sang Patriot Pierre Tendean’s Book
Authors: Alifa Fiona , Maryam Siti
Published: July 2023

Information seeking behavior is one of the interesting topics to be studied so far. Everyone has different information seeking behavior, it is influenced by several factors, such as age, profession, gender, education, beliefs, living environment and so on. This article will discuss the results of research on the information seeking behavior of the authors of a book entitled The Patriot Pierre Tendean. The authors of the book consist of 7 (seven) people and they have different professional backgrounds, some are journalists, teachers, employees, doctors, entrepreneurs, housewives, and travelers. The main purpose of this study was to determine the information seeking behavior of the authors of the book. Besides that, it is also to find out the purpose of writing the book, as well as explore various supporting factors and inhibiting factors faced by the authors in finding the information they need. This study used a qualitative method with a phenomenological approach, and the required data were obtained through in-depth interviews with informants. The informants are six of the seven authors of the book The Patriot Pierre Tendean. The results showed that the information seeking behavior of the six authors had different stages, some were in accordance with Ellis' information seeking behavior model, and some used the Khulthau information search model. Meanwhile, the purpose of writing the book Sang Patriot Pierre Tendean is to provide a book that provides complete and accurate information about Pierre Tendean as one of the revolutionary heroes who died in the events of the September 30th Movement/PKI (G30S/PKI) in 1965. The inhibiting factor faced by these writers was related to licensing to obtain the information they needed, while the supporting factor was their high motivation and enthusiasm in seeking information to meet their needs in completing the writing of the book Sang Patriot Pierre Tendean
Information Seeking Behavior of MAFINDO Fact-Checking Team in Verifying the Truth of Information on Social Media
Authors: Ifan Taufiq Muhammad , Hayati Nurul
Published: July 2023

Information-seeking behavior is an activity in searching for information that is needed or desired with a specific purpose. This study aims to describe the information-seeking behavior of the Masyarakat Anti Fitnah Indonesia (MAFINDO) fact-checking team. The research method used is a qualitative approach with the type of exploratory research. The data obtained are the results of interviews with MAFINDO fact-checkers as informants and literature studies. The results showed that the information-seeking behavior of the MAFINDO fact-checking team was divided into three stages, namely before searching for information, when searching for information, and after searching for information. Before searching for information, the MAFINDO fact-checking team looked for hoaxes to be verified. When searching for information, the MAFINDO fact-checking team looks for references with predetermined criteria using tools or search engines that match the hoaxes to be verified. After searching for information, the MAFINDO fact-checking team used the references obtained, processed them into fact-checking articles, and published them. The behavior of the MAFINDO fact-checking team in conducting information seeking tends to follow Wilson (1981) information-seeking behavior model, Krikelas (1983) information-seeking behavior model, Wilson (1996) search-behavior model, and Ellis information-seeking behavior model which has been developed and expanded by Meho and Tibbo (2003). And there is no visible tendency to follow Kuhlthau (1991) information-seeking behavior model.
The Role of the School Library in Improving Students' Literacy
Authors: Rizaldi Ahmad , Hamdani Fadhilatul
Published: July 2023

This study discusses the literacy activities of students at school, which aims to determine the literacy activities carried out and the library's role in increasing the literacy of SDI Al-Azhar 4 students. In addition, to find out the obstacles and solutions they face. The research method used for this study is a qualitative approach and this type of case study research. Data collection techniques in this study were interviews, observation, and literature review. The results of this study include 1). Although SDI Al-Azhar 4 has not implemented the School Literacy Movement (GLS) in the school curriculum, it has indirectly implemented GLS in their schools through reading activities in class, storytelling, book reviews, and library classes. 2) The library has a role as a facilitator in increasing the literacy of SDI Al-Azhar 4 students by facilitating reading materials, library class hours, and library activities. In addition, the library (librarian) also plays the role of educator in literacy activities through storytelling, watching films, and reading in classes organized by the library. 3). Obstacles libraries face in providing literacy activities, namely reading materials that are easily damaged because they are often read by students, which are then resolved with a solution given a budget for repairs and procurement of new books. Besides that, another obstacle faced is the Covid-19 pandemic which has changed the learning system by not being face-to-face. This problem is given a solution by carrying out literacy activities online.
Power Relations between Shadow Government and Society in Mundzir Qabbani's Hukumatu Dzil Novel
Authors: Syah Ahfa Rahman , Aminah Ismah Nurul
Published: July 2023

This research is supposed to analyze power relations in the Hukumatu Dzil novel by Mundzir Qabbani. This research used the descriptive analysis method that has the purpose of understanding the phenomenon which is experienced by the subject of the research. This research is based on Michel Foucault's theory of power relations and Alain Viala's theory of sequences. Sequencing analysis shows that the power relation between the shadow government to the community is the most dominant issue in the novel. The result shows that practices of power relations in the novel matched Foucault's theory that power is not only carried out through repressive (violence or threats) but can also use in a non-repressive way. Power relations between the shadow government and society occurred through minds and bodies. Power relations through minds occur by manipulation and stigmatization, which are spread through religion, culture, state, and institutions. Meanwhile, power relations through the body occurred by manipulating the social body. The power relations shown by the community against the shadow government are carried out by manipulation through religious media.
The Arrangement of an Arabic Dictionary for Ibtida'iyah Students: A Lexicography Perspective
Authors: Fadilla Tika , Mubarok Muhamad Zacky , Suparno Darsita
Published: July 2023

This study aims to compile an Arabic dictionary that refers to the Arabic language textbook of Madrasah Ibtidaiyah (Al-Lughah Al-Arabiyyah) starting from grades I, II, III, IV, V, and VI which is used as a dictionary for students of Madrasah Ibtidaiyah in the form of a book. This study uses the scientific discipline of Arabic lexicography. The method used in this research is descriptive qualitative method which collects, clarifies and analyzes data in the form of vocabulary without using statistical figures. The translation carried out by researchers uses semantic methods to find out each meaning of the vocabulary. The researchers also uses several supporting dictionaries in translation, including the Al-Munawwir Arabic-Indonesian dictionary, the Al-Ma'any Arabic-Indonesian and Arabic-Arabic dictionary, the contemporary Arabic-Indonesian dictionary (Al-Ashri). The results of this study are in the form of a book-shaped dictionary made using Microsoft Word Program.
Various Meanings of Harf Jar Min in Arabic Studies
Authors: Saputra Muhammad Rinal , Laila Nur , Fajriyanti Shiyam , Hifni Ahmad
Published: July 2023

This article discusses the various interpretations of the harf min in Indonesian by taking a number of examples of verses from the Koran. In the study of Arabic grammar, the harf min is one of the particles that plays a role in changing the final sound of every noun or ism that comes after it, both of nouns in the form of mufrad (singular) and mutsanna (dual) or plural (many). Harfu min is one of the harf jars, while nouns that come after it are called isim majrur. This research is expected to present a comprehensive understanding of the various meanings of harf min. The method used in this research is a qualitative method based on library research. The data sources used are the verses of the Koran, most of which are taken from juz 'amma. This article shows that the harf jar min generally means "of or rather than". However, on the other hand the word min has a variety of meanings other than simply "from or rather than", even in certain contexts it can be interpreted as "to" which is an antonym of the word "from". In addition, sometimes the harfu min is not interpreted at all to conform to the naturalness of the Indonesian language. It was also identified that harfu min in several cases was related to dzahir isim, isim dhamir, harf, and dzaraf. This article concludes that the context of the sentence and the words accompanying min are some of the factors that can give rise to the variety of meanings of harfu min.
Islamic Tenets and Values in Laila Lalami’s The Other Americans
Authors: Febrina Fitri
Published: July 2023

After 9/11, the stereotypes and generalizations against Muslims are exacerbated. By examining Lalami’s The Other Americans, this paper aims to challenge the prejudice and orientalist perceptions towards Muslims and US-Muslims through the aesthetic strategies that the author uses: Islamic tenets and values. The method used for this analysis is a Critical Textual Analysis and engages with Postcolonial Studies, particularly Edward Said's concept of the Othering. The analysis found that prejudicial perception is a challenge through Islamic tenets such as the practice of Qur'an recital and fasting (sawm) which promotes Islam as consolation and peace. The novel also challenges the image of savagery and backwardness in the orientalist views through Islamic values that reflect the qualities of the Prophet Muhammad by depicting the values of perseverance (istiqamah), compassion, and innovation through embracing entrepreneurship. The findings reveal that the prejudiced views of Islam that are maintained by insularity and ignorance are countered by the Islamic tenets and values that are promoted in Islam and practiced by its believers. Thus, Lalami’s novel undermines anti-Muslim racism by exploring Islamic tenets and values, including the Quran and hadiths, practiced by Lalami’s characters who have suffered from the exclusion of U.S. belonging for centuries.
Women and Nature in Homeira Qaderi's Dancing in the Mosque: An Afghan Mother's Letter to Her Son
Authors: Apriatin Sri Nurul , Djohar Hasnul Insani
Published: July 2023

This study explores the relationship between gender and nature in Homeira Qaderi’s Dancing in the Mosque: An Afghan Mother's Letter to Her Son (2020). By engaging with gender studies and ecofeminism, this study aims to evaluate the aesthetic strategies that the author uses to portray the impact of the patriarchal system on Afghanistan Muslim women in Qaderi’s memoir. This paper discovers how the protagonist, Homeira, is depicted as the victim of a male-dominated system in multiple aspects of her life. Indeed, the memoir depicts gender discrimination and gender stereotyping that affected Homeira's life as a marginalized person for decades. Furthermore, Homeira realizes that she should become a pioneer in empowering women to resist the patriarchal system in her country through many symbols, including the symbols of nature, as literary devices. Arguably, within the patriarchal ideology, several values of nature and women as the feminine aspect are seemingly used to oppress women because of the biological aspect of women as reproducing, nurturing, and breastfeeding. To challenge this female oppression, the author uses the symbol of nature, such as wings, birds, phoenix, and spiders, to depict how Homeira’s struggles to achieve her freedom and gender justice. Indeed, the author also uses the symbol of books and stories to reveal how Homeira struggles to achieve higher education. Thus, Qaderi’s memoir complicates the ideas of gender and nature to undermine the patriarchal system in her memoir set in Afghanistan and the US.