bluuebunny/crossref_metadata_2025 huggingface dataset:
Cenário das publicações científicas em carreira e gênero
Authors: Mendonça Fraga Aline , Gemelli Catia Eli , Rocha-de-Oliveira Sidinei
Published: September 2019

Carreira e gênero são temáticas interdisciplinares que se conectam nas trajetórias pelo atravessamento de marcadores sociais de diferenças. Este estudo objetivou analisar a produção científica em carreira e gênero, de 1945 a 2017, indexada na base de dados Web of Science. Por meio de análise bibliométrica, buscou-se examinar a literatura com referência à distribuição temporal; frequência de autoria; distribuição geográfica; distribuição por periódicos; frequência de citações e frequência de termos nos títulos. Os resultados indicaram: crescimento numérico dos estudos; ampliação do entendimento de gênero; mudanças no foco das pesquisas; representatividade da Psicologia e hierarquia do norte global na produção de conhecimento. Com esse mapeamento, evidenciam-se teórica e empiricamente as diferentes vivências objetivas e subjetivas de gênero nas carreiras e as indissociáveis influências de outros marcadores de diferença.
Inovação social em rede no âmbito de um instituto brasileiro
Authors: Vieira Naldeir Dos Santos , Barbosa Allan Claudius Queiroz , Parente Cristina Clara Ribeiro
Published: September 2019

Esse estudo busca analisar a importância das redes interorganizacionais para o desenvolvimento de inovações sociais por meio de estudo de caso qualitativo realizado sobre o Instituto Brasileiro de Desenvolvimento e Sustentabilidade (IABS), com sede na cidade de Brasília. Optou-se pela observação direta, análise documental e realização de entrevistas semiestruturadas como técnicas de coleta de dados. Diante da complexidade de grande parte dos problemas enfrentados pelo Instituto, as redes interorganizacionais foram consideradas como indispensáveis na definição e implementação de estratégias cujos resultados se tornaram sustentáveis no longo prazo e no alcance de maior variedade de dimensões impactadas.
Núcleos de inovação tecnológica (NITs) em instituições de ciência e tecnologia (ICTs): o estado da arte no Brasil
Authors: Zanuto de Freitas Ingrid , Stocker Lago Sandra Mara
Published: September 2019

Esta pesquisa teve como objetivo realizar um levantamento dos estudos publicados de 2008 a 2018 sobre os Núcleos de Inovação Tecnológica (NITs) em Instituições de Ciência e Tecnologia (ICTs). Trata-se de uma pesquisa bibliográfica, exploratória e de revisão sistemática de literatura, em qual as buscas dividiram-se em duas partes: pesquisa de teses e dissertações, e, posteriormente, pesquisa de artigos. Pôde-se perceber que os NITs das instituições brasileiras se encontram em diferentes níveis de estruturação, organização e desenvolvimento e apresentam dificuldades em diferentes dimensões, que vão desde a composição de sua equipe até a dificuldade em lidar com o mercado.
Ethnocultural Features of the Cossacks as a Factor of Preserving Traditional Values in the Language Picture of the World of Modern Youth
Authors: Топалова Екатерина , Topalova Ekaterina , Шафажинская Наталья , Shafazhinskaya Natalya
Published: September 2019

The article is devoted to the analysis of socialization and adaptation of the younger generation, the change of cultural focus, which is largely manifested in the worldview of the generation. The system of values of modern youth and the influence of the spiritual culture of their people and ethnic group on the formation of these values are indicated. The role of the national language, which is the most reliable and scientifically acceptable evidence of the existence of a national character, is also described. The article reflects the most significant meanings and value dominants supported and maintained in the language, which characterize the linguistic picture of the world of the Cossacks and the dominant cognitive zones, which are common in the linguistic picture of the world of modern youth and the Cossacks in the right choice of the vector of spiritual, moral and military-patriotic education. The article pays attention to the need to preserve its own sociocultural matrix and strengthen it with new spiritual and ideological and semantic foundations.
Features of Audit of Accounting (Financial) Statements of the Organizations Which Are Ahead of Schedule Applying in Accounting the Balance Method of Accounting of Temporary Differences
Authors: Сотникова Людмила , Sotnikova Lyudmila
Published: September 2019

Th e article is devoted to the topical practical issues of accounting and auditing arising in connection with the amendments to the Federal accounting standard 18/02 «Accounting of calculations of profi t tax» by the Ministry of Finance of Russia No. 236h from 20.11.2018, the essence of which is that in national accounting practices is being promoted balance method of determining the amount of the current income tax, deferred tax assets and liabilities. The article deals with the principal provisions of the balance sheet method of accounting for diff erences between accounting and tax financial results, the use of which will be mandatory from 2020, while in 2019 it is possible to early voluntary application of the balance sheet method by reporting organizations.
In the Interest of Controlling Financial Flows
Authors: Смирнов Е. , Smirnov E.
Published: September 2019

Th e Russian Parliament continues to strengthen legislative control over the movement of fi nances, taking into account the requirements of the time, the market and the recommendations of the Group for the Development of Financial Measures against Money Laundering. Th e Federal laws No. 32-FZ and No. 33-FZ adopted in the mainstream of this work on March 18, 2019 are designed to signifi cantly activate the market and at the same time limit the possibilities of financial fraudsters.
Combining the Virtues of Stochastic Frontier and Data Envelopment Analysis
Authors: Parmeter Christopher F. , Zelenyuk Valentin
Published: September 2019

A recent spate of research has attempted to develop estimators for stochastic frontier models that embrace semi- and nonparametric insights to enjoy the advantages inherent in the more traditional operations research method of data envelopment analysis. These newer methods explicitly allow statistical noise in the model, the absence of which is a common criticism of the data envelopment estimator. Further, several of these newer methods have focused on ensuring that axioms of production hold. These models and their subsequent estimators, despite having many appealing features, have yet to appear regularly in empirical research. Given the pace at which estimators of this style are being proposed, coupled with the dearth of formal applications, we seek to review the literature and discuss practical implementation issues of these methods. We provide a general overview of the major recent developments in this important arena, draw connections with the data envelopment analysis field, and discuss how useful synergies can be undertaken. We also include simulations comparing the performance of many of the methods presented here.
Effect of abduction on avascular necrosis of the femoral epiphysis in patients with late-detected developmental dysplasia of the hip treated by closed reduction: A MRI study of 59 hips
Authors: Liu Y. H. , Xu H. W. , Li Y. Q. , Hong K. , Li J. C. , Pereira B. , Xun F. X. , Canavese F.
Published: September 2019

Purpose

The purpose of this study was to explore whether increasing the hip abduction angle would increase the incidence of avascular necrosis (AVN) in patients with late- detected developmental dysplasia of the hip (DDH) treated by closed reduction (CR) and spica cast immobilization.

Methods

A total of 55 patients (59 hips) with late-detected DDH underwent MRI after CR. Hip abduction angle and hip joint distance were measured on postoperative MRI transverse sections. The acetabular index and centre-edge angle were measured on plain radiographs at the last follow-up. The presence of AVN according to Kalamchi and McEwen's classification was assessed. We retrospectively analyzed the associations among abduction angles, hip joint distances, radiographic parameters, AVN and final outcomes, exploring the relationship between hip joint abduction angle and AVN rate.

Results

The mean age at the time of CR was 14.4 months SD 5.5 (6 to 28), and the mean follow-up was 26.2 months SD 8.1 (12.4 to 41.7). The mean hip abduction angle was 70.2° SD 7.2° (53° to 85°) on the dislocated side and 63.7° SD 8.8° (40° to 82°) on the normal side; the mean hip joint distance was 5.1 mm SD 1.9 (1.3 to 9.1) on the dislocated side and 2.2 mm SD 0.6 on the normal side (1.3 to 3.3). Eight of 59 hips (13.6%) developed AVN. Neither the amount of abduction nor hip joint distance increased the AVN rate (p = 0.97 and p = 0.65, respectively) or the dislocation rate (p = 0.38 and p = 0.14, respectively).

Conclusion

Abduction angle up to 70.2° following CR did not increase the AVN rate in children aged six to 28 months with late-detected DDH treated by CR.

Level of evidence

III.
Navigating the Publication Process: An ASABE Journals’ Perspective
Authors: Fox Garey A. , Douglas-Mankin Kyle R. , Muthukumarappan Kasiviswanathan , Zhu Jun , Walker Joseph C.
Published: September 2019

Abstract. Highlights

ASABE journals publish impactful research in multiple article types in addition to research articles.

Prospective authors should consider a journal’s peer-review quality, readership, metrics, and page charges.

An article’s impact should be measured based on citations instead of predicted based on the journal’s impact factor.

Always recommend subject matter experts as reviewers so that a manuscript can benefit from their suggestions.

Publishing in ASABE journals offers opportunities for contributing to and being recognized by the profession. Keywords: Impact factor, Page charges, Peer-reviewed journals, Review quality, Review time
Hubungan antara Tingkat Pengetahuan dan Sikap dengan Tindakan Pencegahan Penyakit Rabies pada Warga di Wilayah Puskesmas Kuta II
Authors: Sarjana Ni Kadek Ayu Septiani , Prasetyawati Arsita Eka , Budiani Dyah Ratna
Published: September 2019

Introduction: Rabies is a disease of animals (usually vertebrate) which is zoonotic (transmissible to humans). Rabies occurs in 24 out of the 34 provinces of Indonesia. Rabies is caused by a virus in the Family: Rhabdivoridae, Genus: Lyssavirus. Control the dog population and dog vaccination is effective and economical method to prevent the incidences of rabies in humans. This study aims to investigate the relationship between level of knowledge and attitude to the practice in prevention rabies infection in residents lived in area covered by Puskesmas Kuta II.

Methods: This study was a cross-sectional study and carried out by simple random sampling of 96 residents in the area of Puskesmas Kuta II. In this study, the independent variables are knowledge of and attitudes towards rabies disease while the dependent variable is the practice to prevent rabies infection in human. Data were collected by a questionnaire-based interview. Analyses were then carried out using the chi-square (x2) followed by multivariate analysis using multiple logistic regressions.

Results: This study showed that knowledge has a significant relationship with practice for rabies disease prevention (p = 0.013; OR 4.240; 95% CI 1.352 up to 13.296). Attitude has a significant positive relationship with the value of practice for rabies disease prevention (p = 0.015; OR 3.073; 95% CI 1.233 up to 7.627). The combined effect of knowledge and attitudes to practice for rabies prevention were approximately 20.90% (Negerkerke R square = 0.209).

Conclusions: There was a significant relationship between knowledge and attitudes with the practice for rabies disease prevention in residents in the area of Puskesmas Kuta II, the higher level of knowledge and improved attitudes will improve practice for rabies disease prevention amongst residents in the area of Puskesmas Kuta II.

 

Key words: Rabies;  Rabies;  Preventio; Knowledge; Attitude;  Practice
Potensi Scopoletin sebagai Agonis Reseptor Transferin 2 untuk Pengembangan Terapi Anemia Defisiensi Besi
Authors: Paramanindita Asti Swari , Indarto Dono , Balgis Balgis
Published: September 2019

Introduction: Iron Deficiency Anemia (IDA) is caused by imbalance between iron intake and iron loss in blood circulation. Increased hepcidin level plays an important role in the etiology of IDA. Normally, expression of hepcidin protein is controlled by three different pathways, one of them is interaction between holo Transferin (Holo-Tf) and Transferrin Receptor 2 (TfR-2). Recently, Indonesian herbal plants have widely been used as herbal medicine but there is no active compound that can activate TfR-2 for IDA therapy. The aim of this study was to explore phytochemicals derived from Indonesian herbal plants to interact with TfR-2.

Methods: The study was a bioinformatics study with a molecular docking method. The SWISS-MODEL software was used to make TfR-2 protein modeling because the molecular structure of TfR-2 remains unknown. Holo-Tf was used as a standard ligand and obtained from Protein Data Bank with PDB ID 1SUV. All Indonesian phytochemicals which (1) registered at HerbalDB (2) had a three-dimensional molecular structure at PubChem (3) met Lipinski’s Rule of Five criteria were used in this study. AutoDock Vina 1.1.2 was used to analyze the binding affinity which was in kcal/mol. Phytochemical-TfR-2 binding complexes were visualized by using Chimera 1.10rc and or Pymol 1.7.

Result: The docking scores of holo-Tf modification with TfR-2 were -6,4±0,1 kcal/mol at Arg466 and -3,4±0,1 kcal/mol at Arg689 respectively. Interaction of modification holo-Tf and TfR-2 was observed not only at Arg466 and Arg689 but also with Asp642 and Ile682. Docking scores of scopoletin were -7,1±0,1 kcal/mol at Arg466 and -5,4±0,1 kcal/mol at Arg689. Scopoletin could interact with TfR-2 at Arg466, Arg689, and Leu630 residues.

Conclusions: Computationally, scopoletin is a potential TfR-2 agonist. In future studies, in vitro assay will be used to evaluate the agonist effect of scopoletin in TfR-2.

 
Особенности массопереноса при ионной имплантации
Authors: Абылкалыкова Риза Батырхановна , Квеглис Людмила Иосифовна , Рахадилов Бауржан Корабаевич , Бектасова Гульсум Сафуановна
Published: September 2019

Исследованы продукты реакции, полученные при ионной имплантации азота, кислорода и фосфора в вольфрамовую мишень. Выяснены условия создания новых соединений при высокодозной имплантации, приводящей к процессам быстрого массопереноса ионов в материал мишени. Установлено, что ионная имплантация азота в вольфрам приводит к возникновению фазы внедрения W2N с ГЦК-структурой; имплантация кислорода — к образованию фазы с плотноупакованной ГЦК-структурой, близкой по структуре и параметрам к W20; фосфора — к образованию фосфида вольфрама W2P с орторомбической структурой после дополнительного отжига при температурах, превышающих 800-900 0С. Сделана оценка локального давления потока ионов на поверхность мишени, которое приводит к локальному искривлению кристаллической решетки, благодаря чему возможен быстрый массоперенос имплантированных ионов в материале мишени.

Образование фаз внедрения при ионной имплантации является результатом локализации сдвиговой деформации в условиях ускоренного массопереноса. В условиях высокодозной ионной имплантации формируются высоконеравновесные пересыщенные твердые растворы, а также высокодефектные структурно-неравновесные состояния с высокой кривизной кристаллической решетки.
Ядерное квадрупольное взаимодействие и эффективные заряды атомов в кристаллах YBa2Cu3O7_x и La2_xSrxCuO4
Authors: Доронин Вячеслав Александрович , Марченко Алла Валентиновна
Published: September 2019

Проведено сопоставление параметров эмиссионных мессбауэровских спектров на изотопах 57Co(57mFe), 67Cu(67Zn), 67Ga(67Zn), 155Eu(155Gd) и параметров ядерного магнитного резонанса на изотопах 17O, 137Ba с расчетными параметрами решеточного тензора градиента электрического поля для всех узлов кристаллических решеток высокотемпературных сверхпроводников на основе металлооксидов меди YBa2Cu3O7 и La2-xSrxCuO4. Согласие экспериментальных и расчетных параметров тензора градиента электрического поля может быть получено только для моделей, когда дырка, возникающая за счет нестехиометричности соединения YBa2Cu3O7 или аливалентного замещения La3+ на Sr2+ в соединениях La2-xSrxCuO4, находится преимущественно в подрешетке цепочечного (в YBa2Cu3O7) или плоскостного (в La2-xSrxCuO4) кислорода. Подтверждение предложенной модели пространственного распределения электронных дефектов в решетках La2-xSrxCuO4 (x = 0.1 - 1.0) было получено путем сравнения расчетных зависимостей отношения главных компонент тензоров градиента электрического поля в узлах лантана и меди с отношением постоянных квадрупольного взаимодействия в этих узлах для зондов 57mFe3+, 67Zn2+ и 155Ga3+. Наблюдаемые зависимости могут быть количественно объяснены, если дырка локализуется преимущественно в позициях атомов планарного кислорода. С использованием этих моделей определены коэффициенты Штернхеймера для зондов 67Zn2+, 137Ba2+ и 17O2-.
Теоретические методы выявления нелинейных эффектов при термостимулированной деполяризации в твердых диэлектриках
Authors: Калытка Валерий Александрович
Published: September 2019

Методами квазиклассической кинетической теории исследуется механизм протонно-релаксационной поляризации и термостимулированной деполяризации в кристаллах с водородными связями (КВС). Построены обобщенные выражения для комплексной диэлектрической проницаемости (КДП) и поляризации, выполняющиеся на основной частоте переменного поляризующего поля в бесконечном приближении теории возмущений по малому параметру. Установлено, что эффекты взаимодействия релаксационных мод объемной плотности заряда уже на основной частоте поля обусловливают аномально высокие поляризационные нелинейности, проявляющиеся в области сильных полей (10-1000 МВ/м) и сверхвысоких температур (550-1500 К). Построены обобщенные нелинейные по полю выражения для коэффициентов кинетического уравнения, позволяющие выявить влияние параметров поля (амплитуда и частота ЭДС) на микроскопические акты перебросов физических релаксаторов (протонов) через потенциальный барьер. Из решения общего квазиклассического кинетического уравнения (для модели двойной симметричной потенциальной ямы с барьером параболической формы) построено выражение для плотности тока термостимулированной деполяризации в КВС, выполняющееся в широком диапазоне полей (100-1000 МВ/м) и температур (1-1500 К). Предложена схема численного расчета характеристических параметров релаксаторов методом минимизации функции сравнения (МФС-методом).
Дискретные бризеры в ГЦК и ГЦТ-кристаллах
Authors: Старостенков Михаил Дмитриевич , Захаров Павел Васильевич , Медведев Николай Николаевич
Published: September 2019

Обзор посвящен исследованию дискретных бризеров в кристаллах стехиометрии A3B, AB и в моноатомных кристаллах. Дана краткая история развития концепции дискретных бризеров в кристаллах, рассмотрены возможные пути дальнейших исследований. Приведены данные, свидетельствующие о том, что для существования дискретных бризеров необходимо наличие свойств дискретности и нелинейности исследуемой системы. В рассматриваемых работах исследование дискретных бризеров осуществлялось методом молекулярной динамики с использованием как парных, так и многочастичных потенциалов. На примере кристаллов Pt3Al и CuAu показано, что дискретные бризеры с жестким типом нелинейности способны сосредоточивать энергию порядка нескольких электронвольт, при этом они являются мобильными и могут перемещаться по кристаллу вдоль плотноупакованных направлений. Выявлены два механизма возбуждения дискретных бризеров с мягким типом нелинейности в кристалле стехиометрии А3В потоком частиц. Продемонстрировано, что внешние поля, осциллирующие с частотой вне фононного спектра кристалла А3В, могут являться причиной возбуждения бризеров с мягким типом нелинейности вблизи его поверхности. Для металлов Pt, Au, Ni, Pd, Cu показана зависимость продолжительности жизни ДБ от их коэффициента Пуассона. Приведены амплитудно-частотные характеристики и зависимости времени жизни дискретных бризеров от начальных параметров возбуждения.
Vitamin content in patients with non-insulin-dependent diabetes mellitus
Authors: Sharafetdinov X. X. , Vrheshesinskaya O. A. , Kodentsova V. M. , Beketova N. A. , Pereverzeva O. G. , Kharitonchik L. A. , Meshcheryakova V. A. , Plotnikova O. A. , Spirichev V. B.
Published: September 2019

The sufficiency of vitamins С, A, E. B2, B$, and carotenoids was assessed in 32 patients of both sexes with non-insulin-dependent diabetes on home diets, in spring 1996. A deficit of group В vitamins (56-66%) and carotenoids (50%) was detected in the majority (68.8%) of examinees, while the levels of vitamins C, A, and E were sufficient. Hence, improvement of the vitamin status of diabetics is a most important component of treatment.
The effect of glurenorm on blood pressure in patients with non-insulin-dependent diabetes mellitus with hypertension
Authors: Shustov S. B. , Romashevsky B. V.
Published: September 2019

Effects of long glurenorm therapy on daily arterial pressure (AP), central hemodynamics, and diastolic function of the left ventricle were assessed in patients with non-insulin-dependent diabetes with stages I and II essential hypertension. The patients were divided in 2 groups: group I (n=24) treated with manilil (5-20 mg/day) and nifedipin (20-50 mg/day) and group II (n=24) treated with glurenorm (60-150 mg/day). Control groups consisted of diabetics without arterial hypertension: group III, glurenorm, and group IV, manilil. AP decreased in 88% of patients in groups I and II during the second week of treatment, the maximal decrease was observed by the and of week 12. Decrease of AP in groups I and II was paralleled by a decrease of the total peripheral resistance, improvement of leftventricular diastolic function, and no effect of myocardial contractility. One probable mechanism of the hypotensive and vasodilating effect of glurenorm is decrease of basal insulin level, whose values were higher in groups I and II in comparison with the control and correlated with daily AP values.
Screening for congenital hypothyroidism as an additional method for studying the epidemiology of iodine deficiency diseases
Authors: Suplotova L. A. , Gubina V. V. , Karnaukhov Yu. B. , Kretinina L. N. , Boyarinova I. V. , Gerasimov G. A.
Published: September 2019

Epidemiological screening has been carried out in West Siberia in order to assess the prevalence of iodine deficiencies. The incidence of goiter was assessed, iodine excretion with the urine measured in children, and levels of neonatal thyrotropic hormone (TTH) measured in the course of screening for congenital hypothyrdsis. The findings confirmed the significance of measuring TTH in the newborns for detecting the degree of iodine deficit. The incidence of increased TTH level (more than 25 IU/liter) in the newborns of West Siberia (1.69%) is notably higher than in previously screened provinces of Canada and Australia without iodine deficit and Southern Poland cities with a moderate iodine deficit. Analysis of the frequency distribution of neonatal TTH levels in various geographical regions of the Tyumen district indicates a higher incidence of iodine deficiencies near and beyond the Polar Circle and in the Urals. These findings coincide with previous data on increased incidence of goiter and decreased iodine excretion with the urine in these regions. Monitoring of TTH levels within the framework of program of screening for congenital hypothyrosis can be used to assess the prevalence of iodine deficiencies in the population.
On the correlation of androgens of the testes and adrenal glands with hypogonadism
Authors: Koryakin M. V. , Akopyan A. S. , Vasiliev V. I.
Published: September 2019

Examinations of 14 healthy males, including measurements of the main adrenal and testicular androgens and their precursors, estradiol, and pituitary gonadotropic hormones in the peripheral blood, revealed that the levels of the main adrenal and testicular androgens do not correlate. Assessment of the hormonal status of 24 patients with hypogonadism showed that a deficit in the production of testicular androgens is not compensated for by hyperproduction of adrenal androgens. Testosterone production in patients with acquired anorchism, who were never administered substitute androgen therapy, is about 1/12 of this hormone’s production in health. Hence, the secretion of testicular and adrenal androgens is regulated by different mechanisms.
Interaction of the selective progesterone 16a, 17a-cyclohex-3'-enoprogesterone agonist with the rat uterus progesterone receptor
Authors: Smirnov A. N. , Pokrovskaya E. V. , Shevchenko V. P. , Levina I. S. , Kamernitsky A. V.
Published: September 2019

Binding of [3H]-16a-cyclohex-3'-enoprogesterone (I) and [3 H]-progesterone (II) with soluble fraction proteins of the rat uterus is compared. I specifically reacts with progesterone receptor but not with other proteins. Its affinity to the receptor assessed from Kd (11.6+2.0 nM), Kj (15 nM) values and relative competitive'activity (0.89+0.35 and 0.33+0.04 with [3H]-I and [3H]-II, respectively) is just negligibly inferior to the affinity of the natural hormone (Kd=6.9+2.6 nM, Kj=8.5 nM, relative competitive activity =1). The dissociation of [3H]-I and [3H]-II complexes with the receptor was biphasic with similar constants of dissociation rate (kfI=1.8x.lO'5C'1; кД=4.5*10'4 C1). Specific features of [3H]-I reaction with the receptor in comparison with [3H]-II are a lesser share of rapidly dissociating [3H]-I complexes and a lower capacity of [3H]-I to prevent the receptor degradation. It is probable that the detected features reflect the differences in the receptor conformation and are associated with the selectivity of I action.
The concentration of ascorbic acid in the cerebral cortex and internal organs of rats in chronic and acute hyperglycemia
Authors: Grigoriev I. P.
Published: September 2019

The author hypothesizes a probable causative role of alteration of ascorbic acid concentration in the brain in the development of mental disease in diabetics. In order to verify this hypothesis, ascorbic acid was measured in the brain cortex of rats 21 days after induction of streptozotocin diabetes or 1 h after intraperitoneal injection of glucose in a dose of 5 g/kg. Ascorbic acid level was increased both in diabetes (456+26 yg/g tissue versus 415+37 \vg/g in the control, p<0.01) and in acute hyperglycemia (475+54 \tg/g versus 406+65 \xg/g in the control, p<0.001). This confirmed that changed concentration of ascorbic acid in the brain can promote the development of a mental disease in diabetics. In the liver the concentration of ascorbic acid was decreased in streptozotocin diabetes (by 17%), p<0.001) and increased in acute hypoglycemia (by 24%, p<0.01). The findings permit us to hypothesize that hypoglycemia inhibits the production of ascorbic acid from the liver to the blood in rats and impedes the transport of ascorbic acid through the gut wall into the blood in humans.
Polymorphic genetic markers and vascular complications of diabetes
Authors: Kondratiev Y. Yu. , Nosikov V. V. , Dedov I. I.
Published: September 2019

Diabetes mellitus is a clinically and genetically heterogeneous disease characterized by absolute or relative insulin deficiency and (or) peripheral tissue resistance to the hormone. Each of these disorders individually or in various combinations reduces tissue glucose consumption and increases the concentration of this monosaccharide in the patient’s blood. The state of hyperglycemia is a necessary and, over time, sufficient condition for the development of the so-called late complications of diabetes mellitus (mainly vascular - diabetic angiopathies). These chronic complications of diabetes are the main cause of high disability and mortality in patients, thus representing not only a serious medical and social, but also an economic problem [60]. This problem is exacerbated by the fact that recently there has been a tendency to an increase in the incidence of diabetes [42], the expected prevalence of which by 2010 will be about 215 million people [59]. In addition, the most common form of the disease, non-insulin-dependent (type II) diabetes mellitus (NIDDM), is characterized by delayed diagnosis and under-detection of the disease in the general population, leading to a significantly underestimated estimate of its prevalence [29, 30].
Diabetes mellitus and coronary heart disease
Authors: Chazova T. E. , Melnichenko G. A.
Published: September 2019

Atherosclerosis and related disorders of carbohydrate metabolism go beyond narrow cardiological problems and, in one way or another, are the subject of close attention of doctors of various specialties, including endocrinologists. In everyday practice, most endocrinologists leave the solution of issues related to hyperlipidemia “for later”, because, first, for many decades, full compensation for diabetes and hypothyroidism - conditions in which secondary hyperlipidemia is most common - was difficult ; secondly, there were no effective and safe means for treating hyperlipidemia, which made generations of doctors skeptical about the possibility of real correction of lipid metabolism disorders. Improving the methods for compensating for diabetes mellitus and the possibilities for treating hypothyroidism have brought clinicians to the problem of the need for additional therapy with lipid-lowering drugs, so the pathogenesis and treatment of hyperlipidemia are of great interest to them.
The optimal diagnostic complex in the surgical treatment of nodular euthyroid goiter
Authors: Vetshev P. S. , Kuznetsov N. S. , Chilingaridi K. E. , Vanushko V. E. , Ozerov S. K. , Gabaidze D. I.
Published: September 2019

Different methods for preoperative diagnosis of nodular euthyroid formations of the thyroid gland are compared. The sensitivity and specificity of ultrasonic examination (based on the study of the semeiotics of nodular formations of the thyroid), fine-needle aspiration biopsy (under palpation and ultrasonic control), and complex diagnosis (simultaneous assessment of ultrasonic semeiotics of the nodular formation and controlled biopsy under ultrasonic control followed by cytological examination of puncture biopsy specimens) are assessed. With this aim in view, 342 patients with nodular euthyroid formations were examine^ in 1994-1996. Benign nodular formations were detected in 316 (92.4%)) and thyroid cancer in 26 (7.6%o) patients. In the group with benign formations, colloid goiter was diagnosed in 204 (59.7%), follicular-cell adenomas in 78 (22.8%)), and hypertrophic autoimmune thyroiditis in 34 (9.9%) cases. The authors consider that ultrasonic examination combined with fine-needle aspiration biopsy is the most available, safe, and highly effective complex for the diagnosis of nodular euthyroid formations at the preoperative stage. Complex preoperative ultrasonic examination with fine-needle biopsy help single out the group with suspected malignant involvement of the thyroid with a high probability. Use of this complex and intraoperative ultrasonic examination correctly identified the type of thyroid involvement and its morphology in 92.4%o of cases, and thus helped choose adequate volume of intervention.
The effect of normobaric hypoxia on the secretion of insulin and growth hormone
Authors: Starkova N. T. , Davydov A. L. , Koroleva A. V.
Published: September 2019

Effect of normobaric hypoxia on insulin (IRI) and somatotropic hormone (STH) secretion was studied in 24 normal subjects aged 35-55 years. Control group consisted of 18 subjects administered placebo. Adaptation to normobaric hypoxia was attended by changes in IRI and STH but not in the glycemia level. Hypoxic exposure was associated with an increase of the plasma STH concentration and a tendency to normalization of IRI in all examinees. These parameters correlated with body weight index.
The effect of normobaric hypoxia on the level of organ-specific and organ-specific antibodies in individuals with thyroid diseases
Authors: Koroleva A. V. , Davydov A. L. , Dmitrieva M. Yu.
Published: September 2019

Time course of organ-nonspecific and organ-specific antibodies during normobaric interval hypoxic training (IHT) is followed up in 25 normal subjects and 34 patients with thyroid diseases in a state of euthyrosis. Hypoxic test was carried out in all examinees before and after IHT. IHT was performed in individual regimens of inhalations of hypoxic gas mixture and ambient air alternatively. The initial titers of antibodies to different organs and tissues were higher in the patients than in normal subjects. According to hemodynamic parameters, the tolerance of hypoxia improved after adaptation of patients to normobaric hypoxia. The euthyrosis status did not change. Antibody titers significantly decreased after IHT both in the patients and normal subjects. IHT had a positive effect on the humoral immunity. IHT is recommended for patients with thyroid diseases to be used in complex with other methods of treatment.
Venous renal hypertension and androgenic adrenal function
Authors: Koryakin M. V. , Akopyan A. S. , Vasiliev V. I.
Published: September 2019

Study of the adrenal androgenic function in patients with venous renal hypertension showed a notable increase of the levels of 17-a.-hydroxypregnenolone and DHEA-C in the peripheral blood and of DHEA-C excretion with the urine. Analysis of venous circulation in the left adrenal in the patients with venous renal hypertension brought the authors to a conclusion that hyperproduction of androgens in the left adrenal cortex is due to a paracrine mechanism. Retrograde bloodflow developing in the deep venous system of the left adrenal during pressure increase in the left renal vein leads to release of catecholamines from the medullary layer to the cells of the upper cortical layers of the organ. Adrenaline stimulation of steroidogenesis in the cortical cells, in turn, causes hypersecretion of androgens. Based on these data, the authors propose a hypothesis about a new mechanism regulating the androgen function of the adrenals.
Monitoring diabetic retinopathy in children with insulin-dependent diabetes mellitus
Authors: Milenkaya T. M. , Shcherbacheva L. N. , Peterkova V. A. , Terentyev V. S. , Maksimova V. P. , Dedov I. I.
Published: September 2019

A total of 185 children (93 boys and 92 girls) aged 6 months to 15 years and disease duration of 1 to 13 years, residents of different regions of Russia, were examined. Pathological changes of the retina caused by diabetes were detected on the fundus oculi of 56 (30.3%) children. In 42 (22.7%)) of these, the initial changes (solitary retinal hemorrhages, microaneurysms) and in 14 (7.6%)) more pronounced micro- vascular pathological changes typical of nonproliferative diabetic retinopathy were detected, in 2 patients - the proliferative stage. Later argon coagulation of the retina was carried out in 10 patients with nonproliferative diabetic retinopathy and in 2 with proliferative diabetic retinopathy. The initial stages of nonproliferative and proliferative diabetic retinopathy are an indication for laser coagulation in children. The status of 6 (50%) children improved in remote periods (6-24 months) after laser coagulation: hemorrhages resolved and microaneurysms decreased; in 4 (33.3%) children the process was stabilized. Deterioration was observed in 2 (16. 7%o) children with nonproliferative and proliferative diabetic retinopathy.
On the interaction of cytosolic complexes of the glucocorticoid receptor and synthetic glucocorticoid responsive element
Authors: Solenov E. I.
Published: September 2019

The constant of affinity between glucocorticoid receptor (GR) complex isolated together with triamcinolone and a synthetic oligonucleotide glucocorticoid-responsive element (GRE) corresponding to the GRE-1 sequence of the rat thyrosine aminotransferase gene promoter is assessed. Singlestranded oligonucleotides with the straight sequence (Kd 0.2 ± 0.006 pM) possess the highest affinity for GR. The affinity of single-stranded oligonucleotides with antisense sequence is far lower (Kd 1.5 ± 0.2 pM), but is superior to that of double-stranded oligo GRE (Kd 12.0+ 1.1 pM). The results suggest that the complexes are formed mainly with the sense strand of DNA; on the other hand, it is probable that the reaction of glucocorticoid receptor with GRE promotes conformational changes of DNA in this gene region.
Endoscopic adrenalectomy
Authors: Vetshev P. S. , Ippolitov L. I. , Gabaidze D. I.
Published: September 2019

The widespread use of endoscopic surgery over the past 10 years is primarily associated with scientific and technological progress, the improvement of endoscopic video equipment, special tools necessary for ultra-precise operating techniques. Some laparoscopic surgeries have already been recognized by experts and are the method of choice in the treatment of a large number of patients, others are still at the stage of clinical trials and a set of sufficient observations to generalize [2, 10, 47].
Primer caso de endocarditis por Abiotrophia defectiva en paciente adulto con coartación aórtica en hospital de Santa Fe
Authors: Valletto Mónica Beatriz , Mollerach Analía Susana , Nagel Alicia , Manias Valeria , Nardín María Elena , Mendosa Maria Alejandra , Morano Susana Teresita , Ramos Claudia Fabiana , Méndez Emilce De los Angeles , Nepote Andrea , Vay Carlos
Published: September 2019

Abiotrophia defectiva,  previamente conocida como variante nutricional  de estreptococos forma parte de la microbiota normal de la cavidad oral, urogenital y tracto gastrointestinal. Se asocia con infecciones severas como bacteriemia, endocarditis, abscesos cerebrales, osteomielitis, artritis séptica y queratopatía del cristalino. Es un microorganismo difícil de diagnosticar y las tasas de morbimortalidad, son altas.Se presenta el caso de  un paciente adulto joven con coartación aórtica, con antecedentes de miocardio no compacto y comunicación ventricular pequeña, que consulta por cuadro de 16 días de evolución, caracterizado por dolor en la región glútea y fiebre.Se solicitan tres muestras de hemocultivos que se procesaron por método automatizado BACTEC (Phoenix). Las tres muestras de hemocultivos resultaron positivas a las 48 h para cocobacilos grampositivos en cadena. La identificación del aislamiento se realizó con autoanalizador BD PhoenixTM  System dando como resultado Abiotrophia/Granulicatella, confirmándose por espectrometría de masas (MALDI-TOF) como Abiotrophia defectiva.Se realizó  tratamiento antibiótico  inicial con ampicilina, gentamicina y vancomicina por 7 días, continuando con ceftriaxona más gentamicina durante 22 días, evolucionando  favorablemente.Debido a este hallazgo es importante alertar a los infectólogos y microbiólogos, considerar a Abiotrophia defectiva como posible agente causal  de endocarditis.
RESÚMENES DE TESIS: DOCTORADO EN EDUCACIÓN EN CIENCIAS EXPERIMENTALES
Authors: Vignatti Maria Del Carmen
Published: September 2019

Diseño y desarrollo de un Laboratorio Remoto para la enseñanza de la física en la UNED de Costa RicaCarlos Alberto Arguedas Matarrita

Profesores de física de la Mesoregión de Bahía. Aspectos históricos, formación y trabajo docenteFerdinand Martins Da Silva
RESÚMENES DE TRABAJOS FINALES INTEGRADORES: ESPECIALIZACIÓN EN VINCULACIÓN Y GESTIÓN TECNOLÓGICA
Authors: Vignatti Maria Del Carmen
Published: September 2019

Sistemas de financiamiento utilizados en las Empresas de Base Tecnológica incubadas en el Parque Tecnológico Litoral CentroMaría Lucia D ́Jorge
La identidad en el aula de lengua extranjera
Authors: Muth Randy
Published: September 2019

El presente texto indaga en la estrecha relación entre el aprendizaje y la formación de la identidad, así como en la necesidad de implementar metodologías y políticas que tengan en cuenta los factores sociales que puedan fomentar o desfavorecer el progreso del estudiante. Particularmente, intenta esclarecer la relación entre el aprendizaje de una lengua extranjera y la construcción de la identidad, y destacará la manera en que el contexto social condiciona este vínculo.
Cómo corrige el docente de Lengua Castellana
Authors: Parrales Rodríguez Aída Bárbara
Published: September 2019

Corregir es una de las tareas más cotidianas para un docente, pero la corrección de textos es una actividad compleja, así que nos preguntamos: ¿cómo corrige el docente de Lengua los textos de sus alumnos? ¿Cómo intenta subsanar los errores que cometen? Para contestar a estas preguntas encuestamos a los docentes de Lengua Castellana y Literatura de la ESO y de tercer ciclo de Educación Primaria del municipio de Oviedo.
Transformar la mirada. La educación como herramienta poderosa de transformación social
Authors: Martínez Cano Silvia
Published: September 2019

A las puertas de la tercera década del s. XXI nos encontramos con una educación transformada, bajo la apremiante insistencia de los cambios culturales. La cultura promueve la diversidad y la capacidad de adaptación a los cambios culturales y tecnológicos a través de un aprendizaje constante. En ella, los docentes se abren a una educación más comunitaria, solidaria y responsable que utiliza la cultura para educar y para producir, también, nuevos imaginarios culturales que promuevan la conciencia crítica y la equidad.
Publications Output of the Indian Association for the Cultivation of Science during 2008 2017 a Scientometric Assessment
Authors: Mondal Dhiman , Chakrabarti Biplab , Maity Arabinda
Published: September 2019

The present scientometric study assesses the publication output of the scientists of Indian Association for the Cultivation of Science (IACS) during 2008 to 2017 as reflected in the Web of Science database to figure out the research performance, scholarly communication behaviour and its citation impact. The scientists of IACS contribute total 4,304 research articles including 22.58 percent international collaborated articles. Further, the publications have been evaluated in terms of year, types of collaboration, authorship pattern, source journals, impact factor, collaborating institutions, collaborating countries and citations. It is found that majority of the published articles are produced by three authored and the international collaborated articles which receive wider citation impact. The developed countries like USA, Japan, Germany and England are found as the most favoured countries by the scientists of IACS for research collaboration and the Journal of Physical Chemistry C shares maximum research articles. Further, Pareto’s 80/20 principle has also been applied to examine the scattering of journals as well as articles and the VOS viewer software has been used for mapping the network of collaborating countries.
Exploring the Soft System Methodology in Development of Knowledge Management Conceptual Model a Sytematic Literature Review
Authors: Sensuse Dana Indra , Gandhi Arfive , Sucahyo Yudho Giri
Published: September 2019

Soft System Methodology (SSM) is common guidance to conceptualise Knowledge Management (KM) model since its benefit to handle complex situations. This study highlights SSM implementation on KM conceptual model using Systematic Literature Review (SLR) to produce insights about current implementation and promising chances in the future. This study also concerns on KM conceptual models as created without certain features in many case studies. Many various interpretation can arise to understand how system should work. This situation affected more spending time to validate KM conceptual model with stakeholders. Using SLR, this study criticises the importance of features as provided in eligible articles. Out of 144 articles from 2009 until 2019 as delivered from Scopus query, this study selected 12 articles about SSM on KM. It classified them into several criteria: published year, sector, and related KM life cycle. By mapping them to solve research questions, this study promoted actors, activities, and sequential order of activities as recommended features. By implementing them, KM conceptual model creation can be faster and accepted by stakeholders.
CHALLENGING POTENCY OF JAYENGAN : NEW OPPORTUNITY FOR DEVELOPMENT OF SUSTAINABLE JEWELRY CREATIVE INDUSTRIAL KAMPUNG-BASED TOURISM IN SURAKARTA
Authors: Astuti Winny
Published: September 2019

Local-based tourism becomes one of economic development strategies of the area based on local potency. Sustainable tourism can be defined as ‘tourism, which takes into account of its current and future economic, social and environmental impacts’, addressing the demands of visitors, the environment, the industry and local communities as the host of development. KampungJayengan Surakarta is the traditional settlements located in the downtown, which spontaneously developed by Banjar Community, that arrived in Surakarta in 1746 as jewelry traders. Right now, the existence and the identity of Kampung Jayengan as Kampung of Jewelry has been lost its attraction, constrained by development of modern public facilities and services in the city center. This study analyzed the challenge faced by Kampung Jayengan to develop its potencies as Jewelry Industrial Kampung-based Tourism becoming a part of tourist destination in Surakarta as a creative city. The research type was predictive research  using mixed methods. Several analysis have been conducted from identification of the potencies of kampung. It consisted of analysis comformity of the area to the spatial structure general plan policy; analysis of demographic; analysis of economy, analysis of availability of public infrastructure; analysis of building and environment and analysis of land use suitability.  Results of analysis shows that the area has a great challenge for Jewelry Industrial Kampung-based Tourism development, which will have multiplier effect on increasing economic development of the area as well as economic development and welfare of the local community
Effects of zeolite inclusion in aflatoxin B1-contaminated diet on the performance of laying duck
Authors: Sumantri I. , Herliani H. , Rajibi A. N. , Edriantina R.
Published: September 2019

The researchwas objected to study the effect of zeolite inclusion in aflatoxin B1 (AFB1) contaminated diet on the performance of laying duck. A completely randomized design was adopted in the in vivo experiment that consisted of 4 treatments, namely: (1) commercial feed (Control); (2) AFB1-contaminated feed 70 ppb (AFC); (3) Control + 2% zeolite; and (4) AFC + 2% zeolite. Each treatment had 4 replications with 4 ducks in each replication. A total of 64 eight months-female Alabio duck (Anas platyrinchos Borneo) were used in 28 days of the feeding experiment. Data were analyzed according to the general linear model of SPSS 21.0 statistical software. Results indicated that AFB1 exposure significantly (P<0.05) decreased the body weight of laying duck by 1.12%. Zeolite inclusion could prevent the adverse effect of AFB1 on body weight that increased by 2.95% in AFC+2% zeolite. Treatments had no significant effect on egg production and egg weight (P>0.05). Zeolite inclusion resulted in the highest final body weight whilst AFB1 diet without zeolite resulted in the lowest final body weight (P<0.05). Relative liver weight of duck fedAFC diet was 16.62% and to be 15.4% by zeolite addition in the diet. In conclusion, 2% of zeolite inclusion could reduce the adverse effects of AFB1 exposure on the performance of laying duck.