bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of breathable and liquid/wet bacterial penetration barrier composite laminated fabrics for surgical gown applications
Authors: El-Ghoubary Walaa Abdou , El-Sayad Ghada Mohammed , El Gamal Fayrouz Aboelfotouh , Abouzaid Hanaa Abouzaid Khalil
Published: May 2023

Disposable surgical gowns are used to protect health care workers from microorganisms and body fluids to meet the needs of surgical applications. In addition to protection, it has a significant impact on the surgical team members’ comfort and thus, the success of the operations. In this study, a dual layer surgical gown-an outer layer of film and an inner layer of nonwoven fabric-was developed. Produced composite laminated fabrics are SMS (spunbond/meltblown/spunbond) nonwoven fabric laminated microporous polyethylene film and SMS (spunbond/meltblown/spunbond) nonwoven fabric laminated thermoplastic polyurethane films. These fabrics were compared with nonporous polyethylene film-coated SS (spunbond/spunbond) nonwoven fabric available in the local market. The study aims to investigate the effect of some structural factors of composite nonwoven laminated fabrics, including lamination process, manufacturing process, and film type; microporous or monolithic, nonwoven fabric manufacturing process, and helium atmospheric-pressure glow discharge plasma treatment, on their functional performance properties, including air permeability, water vapour permeability, hydrostatic pressure resistance, and wet bacterial penetration resistance. The results showed that the produced composite fabrics offer outstanding breathability and, thus, the surgical team members' comfort. Produced composite fabrics had no wet bacterial penetration of Staphylococcus aureus and thus contributed to the prevention of the transfer of bacterial pathogens to prevent surgical site infection or post-operative infection. Produced composite fabrics offer superior liquid barriers according to the barrier protection classification of the Association for the Advancement of Medical Instrumentation (ANSI/AAMI PB 70:12) and thus contribute to the prevention of the transfer of body fluids during surgical operations.
Challenges of Glycemic Control in People With Diabetes and Advanced Kidney Disease and the Potential of Automated Insulin Delivery
Authors: Lu Jean C. , Lee Petrova , Ierino Francesco , MacIsaac Richard J. , Ekinci Elif , O’Neal David
Published: May 2023

Diabetes is the leading cause of chronic kidney disease (CKD) and end-stage kidney disease in the world. It is known that maintaining optimal glycemic control can slow the progression of CKD. However, the failing kidney impacts glucose and insulin metabolism and contributes to increased glucose variability. Conventional methods of insulin delivery are not well equipped to adapt to this increased glycemic lability. Automated insulin delivery (AID) has been established as an effective treatment in patients with type 1 diabetes mellitus, and there is emerging evidence for their use in type 2 diabetes mellitus. However, few studies have examined their role in diabetes with concurrent advanced CKD. We discuss the potential benefits and challenges of AID use in patients with diabetes and advanced CKD, including those on dialysis.
Do They Even Need “Adult” Education? A Programming Critique of Day Habilitation
Authors: Gerken Lauren , Baumgartner Lisa M.
Published: May 2023

Day habilitation provides informal and non-formal adult education programming for individuals with disabilities, who often go unrecognized by the adult education field because of infantilization that precludes them from common perceptions of “adults,” contributing to a dearth of information about day hab access and programming in adult education literature. In this paper, we critically examine day hab access and programming issues in Texas, discussing barriers regarding costs and stigmas toward attendees from adult educators’ perspectives. We include practical recommendations for the field, such as embracing person-centered approaches and entering discussions about day habilitation programming to improve outcomes for participants.
The Role of Fractional Exhaled Nitric Oxide in Diagnosing Asthmatic Type 2 Chronic Rhinosinusitis With Nasal Polyps
Authors: Park Jin-A , Cha Hyunkyung , Yang Seung Koo , Ryu Hyun Tae , Kim Do Won , Hong Seung-No , Yang Min Suk , Kim Dae Woo
Published: May 2023

Background

Fractional exhaled nitric oxide (FeNO) is useful in the management of asthma and predicting the efficacy of standard corticosteroids and biologics. However, the diagnostic value of FeNO in asthmatic chronic rhinosinusitis with nasal polyps (CRSwNP) remains unclear.

Objective

We assessed FeNO levels in patients with CRSwNP and evaluated the diagnostic value of FeNO for screening type 2 CRSwNP (T2-CRSwNP) with asthma.

Methods

We enrolled 94 patients who were diagnosed with CRSwNP and underwent functional endoscopic sinus surgery. FeNO levels, the blood eosinophil percentage, total IgE, spirometry tests (FEV1/FVC), Lund–Mackay CT score, and percentage of patients with comorbid asthma were compared among CRSwNP subgroups. Spearman rank correlation test was used to assess the degree of association between variables. ROC curve analysis was conducted to evaluate the diagnostic capability to differentiate T2-CRSwNP based on clinical and histological classifications.

Results

FeNO levels and the blood eosinophil percentage were significantly higher in patients with T2-CRSwNP(h) based on histological data ( P < .05). FeNO was correlated with the blood eosinophil percentage ( r = 0.420, P < .001) and FEV1/FVC ( r = −0.324, P = .001). A FeNO level of 27 ppb had a good ability to discriminate patients with asthmatic T2-CRSwNP(h) (AUC = 0.848; 95% CI = 0.7602-0.9361; sensitivity = 90.9%; specificity = 63.9%). The optimal cutoff values for FeNO and the blood eosinophil percentage for diagnosing asthmatic T2-CRSwNP(h) were 68 ppb and 5.6% (sensitivity = 95.5%; specificity = 86.1%; AUC = 0.931; 95% CI = 0.8832-0.9791). In the diagnosis of severe T2-CRSwNP(c) based on clinical data, a FeNO level of 36 ppb showed the highest AUC (0.816; 95% CI = 0.7173-0.914; sensitivity = 72.7%; specificity = 79.2%).

Conclusion

FeNO is a useful marker for screening asthmatic T2-CRSwNP even prior to biopsy or asthma evaluation and may assist in selecting a proper treatment.
Efgartigimod alfa for the treatment of primary immune thrombocytopenia
Authors: Broome Catherine
Published: May 2023

Primary immune thrombocytopenia (ITP) is an acquired autoimmune disorder characterized by isolated thrombocytopenia. Most patients with ITP have antiplatelet antibodies of the immunoglobulin G (IgG) subtype which through interaction with platelet and megakaryocyte glycoproteins result in increased platelet destruction and inhibition of platelet production. There are a variety of therapeutic options available for the treatment of ITP including corticosteroids, IVIgG, TPO-RA, rituximab, fostamatinib, and splenectomy. Long-term remissions with any of these therapies can vary widely and patients may require additional therapy. The neonatal Fc receptor (FcRn) plays a pivotal role in IgG and albumin physiology through recycling pathways. Efgartigimod is a human IgG1-derived fragment that has been modified by ABDEG technology to increase its affinity for FcRn at both physiologic and acidic pH. The binding of efgartigimod to FcRn blocks the interaction of IgG with FcRn facilitating increased lysosomal degradation of IgG and decreasing total IgG levels. Based on the mechanism of action and the known pathophysiology of ITP as well as the efficacy of other therapies such as intravenous immunoglobulin (IVIG), the use of efgartigimod in patients with ITP is attractive. This article will briefly discuss the pathophysiology of ITP, current treatments, and the data available on efgartigimod in ITP.
Synthesis and characterization of nanocellulose from watermelon rinds and water hyacinth
Authors: PK Remya , MS Manju , Sunil Abith , KS Athulya , Joseph Jerome , TU Jyothsna
Published: May 2023

Nanocellulose derived from cellulose, the abundant natural polymer, is used in various applications due to its superior chemical, mechanical and thermal properties along with good biocompatibility and biodegradability. This paper reports an investigation of the extraction of nanocellulose from two freely available natural precursors-watermelon rinds and water hyacinth leaves. Cellulose isolation was carried out through chemical methods, including acid and alkali treatments followed by bleaching. The chemical composition, percentage crystallinity and particle size were studied using various characterization techniques. FTIR spectra indicate the removal of hemicelluloses, pectin, and lignin resulting in the effective isolation of cellulose from both precursors. Results of XRD indicate a high concentration of Cellulose Nanocrystals (CNCs) in the treated sample. The FESEM and SEM-EDAX images also confirm the formation of CNCs. TGA and DSC results show excellent thermal stability for both CNCs. Investigations on the properties of a CNC-reinforced epoxy composite are also reported. Results indicate considerable improvement in the mechanical properties, thermal stability and thermal conductivity of the composites compared to the pristine polymer.
Customary Arbitration: Religion, Culture, and Law in Igboland
Authors: Ifeanyi Okeke Johnson
Published: May 2023

The Igbo traditional religion provides institutions for the amicable, natural, and lasting resolutions of conflicts within Igboland. One of such institutions is the Igbo customary arbitration mechanism. This article aims at unavailing and bringing to the fore, the numerous positive aspects of customary arbitration which include the quick dispensation of justice, less financial implications, and purposeful and acceptable awards. It uses indigenous procedures and actors in arriving at an award. It focuses on the deployment of cultural, religious, and legal components in its procedures and findings. It therefore offers a better alternative as litigants could benefit from it. The practice also encourages cultural revival. This study makes use of documents, interviews, and observational methods while deploying a sociological (functionalist) methodology in its analysis.
A case of feline gastrointestinal eosinophilic sclerosing fibroplasia associated with fungal colonisation: endoscopic features, treatment and follow-up
Authors: Martineau Michael , Tilmant Cyril , Risco Castillo Veronica , Guillot Jacques , Reyes-Gomez Edouard , Benchekroun Ghita , Freiche Valerie
Published: May 2023

Case summary

A 5-year-old castrated male domestic shorthair cat presented with a 3-month history of weight loss, chronic diarrhoea and vomiting. Examination revealed a large proximal duodenal lesion eventually diagnosed as feline gastrointestinal eosinophilic sclerosing fibroplasia (FGESF) associated with fungal filaments. Histological examination was performed following endoscopic biopsy. Direct examination and mycological culture of the duodenal biopsies revealed the presence of a siphomycetous fungus, which was further identified as Rhizopus microsporus. Treatment with prednisolone and ciclosporin for 3 months led to complete resolution of the clinical signs and marked improvement of the endoscopic lesions. Specific fungal treatment with amphotericin B was poorly tolerated.

Relevance and novel information

To the best of our knowledge, this is the first report of the characterisation of a siphomycetous fungus associated with FGESF lesions, and the first endoscopic description and diagnosis of FGESF without surgical biopsies. We hypothesise that the presence of R microsporus occurred because of disrupted mucosal integrity.
Fear of Missing Out: An Antecedent of Online Fan Engagement of Sport Teams’ Social Media
Authors: Lee Younghan , Na Sangwon
Published: May 2023

Fear of Missing Out (FoMO) is the apprehension stemming from missing out on social interactions, and it is a salient motive for sport consumption. Sport fans are active and engaged on social media, and they give Continuous Partial Attention (CPA) to other screens, displaying online behaviors such as accessing team social media channels while watching live sports on screens. Confirmatory factor analysis and structural equation modeling were performed to examine the role of FoMO, with mediations of social media involvement and CPA, on fans' online engagement with sports teams' social media. Participants ( N = 328) demonstrated that fans with FoMO have a desire to continuously connect with other fans while watching live sports on screens, which leads to engaging in social media activities related to the sport team. This study provides theoretical and practical implications related to sport fans' social media information-seeking behaviors and for social media managers of sports teams, including the operations of live broadcasts during sports games.
Contextual Lateralization Based on Interaural Level Differences Is Preshaped by the Auditory Periphery and Predominantly Immune Against Sequential Segregation
Authors: Laback Bernhard
Published: May 2023

The perceived azimuth of a target sound is determined by the interaural time difference and the interaural level difference (ILD) and is subject to contextual effects from precursor sounds. This study characterized ILD-based precursor effects (PEs) for high-frequency stimuli in a total of seven normal-hearing listeners. In Experiment 1, precursor and target were band-pass-filtered noises approximately centered at 4 kHz (1.2- and 1-octave bandwidth, respectively) separated by a 10-ms gap. The effects of precursor location (ipsilateral, contralateral, and central) on the perceived target azimuth were measured using a head-pointing task. Relative to control trials without a precursor, ipsilateral precursors biased the perceived target azimuth toward midline (medial bias) and contralateral precursors biased it contralaterally (lateral bias). Central precursors caused a symmetric lateral bias. An auditory periphery model that determines the “internal” ILD at the auditory nerve level, including either realistic efferent compression control or auditory nerve adaptation, explained about 50% of the variance in the PEs. These within-trial PEs were accompanied by an across-trial PE, inducing medial bias. Experiment 2 studied the role of sequential segregation in the within-trial PE by introducing a pitch difference between precursor and target. Segregation conditions caused increased PE for ipsilateral, no effect for contralateral, and either no effect or reduced PE for central precursors. Overall, the ILD-based within-trial PE appears to be preshaped already in the auditory periphery and the mechanism underlying at least the ipsilateral PE appears to be immune against sequential segregation.
Support Experiences for Novice Nurses in the Workplace: A Qualitative Analysis
Authors: Najafi Bahareh , Nasiri Ahmad
Published: May 2023

Introduction

Since novice nurses need support at the beginning of their work, knowing workplace support resources can help them to experience fewer challenges at the beginning of their work and improve the quality of patient care.

Objective(s)

The present qualitative study aimed to explore novice nurses’ experiences of supporting the workplace at the beginning of their work.

Design

This qualitative study was performed using a content analysis method.

Methods

This qualitative study was conducted with 14 novice nurse participants using the conventional content analysis method, unstructured in-depth interviews were used to collect data. All data were recorded, transcribed, and analyzed based on the Graneheim and Lundman method.

Results

Two major categories and four subcategories were extracted during data analysis as follows: (1) An intimate work environment with subcategories of cooperative work atmosphere and empathetic behaviors, (2) Educational support available for improvement contains subcategories conducting orientation courses and holding retraining courses.

Conclusion

The present study showed that such experiences as an intimate work environment, and educational support help novice nurses to have a supportive workplace and improve their performance. A welcoming and supportive atmosphere should be created for newcomers to ease their anxiety and frustration. Furthermore, they can improve their performance and provide quality care by giving themselves the motivation and spirit of improvement.

Relevance to Clinical Practice

This research highlights the need for new nurses to have support resources in the work environment, and healthcare managers can improve the quality of care by allocating sufficient support resources to this group of nurses.
Landscapes of dispossession: Criminal justice and property rights in Mexico (2015–2020)
Authors: Meneses-Reyes Rodrigo , Fondevila Gustavo , Galindo Carlos
Published: May 2023

It is generally accepted that the State plays an important role in promoting and facilitating practices of dispossession; yet there is little reflection on its role in prevention, processing, and reversion (restitution). Our research focusses on dispossession understood as a crime. The criminal classification of dispossession as well as the continued reporting of its frequency and magnitude, suggest that crucial State institutions, such as those which form part of the criminal justice system, play a determining role in both how certain property conflicts are denominated as well as the trajectory, duration, and ways in which these are processed. Using a spatial analysis of criminal records of dispossession on a municipal level, from 2015 – 2020 in Mexico, we aim to demonstrate dispossession as a highly collective, contested, and concentrated process of changing relations of land and property that materialize in unequal ways on specific regulated spaces, rather than as a random occurrence on institutionally and socially empty territories.
Repair of a Reverse HAGL: A 2-Portal Technique
Authors: Goodloe J. Brett , Schwartz Joshua M. , Tagliero Adam J. , Klosterman Emma L. , Brockmeier Stephen F.
Published: May 2023

Background:

Glenohumeral joint stability is reliant on a combination of static and dynamic constraints. Humeral avulsion of the posterior band of the inferior glenohumeral ligament (HAGL) is an exceedingly rare injury. These injuries can be difficult to diagnose and can lead to continued pain, dysfunction, and recurrent instability. There is a paucity of literature regarding surgical management of reverse HAGL lesions.

Indications:

Many intrasubstance reverse HAGL lesions can be managed nonoperatively with rehabilitation focused on improving shoulder stability. Although the incidence of recurrent instability in patients with reverse HAGL lesions is unknown, the acute detached humeral lesions in athletes are often treated surgically to restore normal shoulder.

Technique Description:

The patient was placed in a standard beach chair position, and the standard portals were made for a diagnostic shoulder arthroscopy. The anterior portal was the primary viewing portal. Using the initial posterior skin incision, instruments were introduced through the defect from the retracted posterior band of the inferior glenohumeral ligament. Using a combination of the 30° and 70° arthroscope, the HAGL was mobilized from the infraspinatus musculature. Two knotless suture devices (1.8-mm suture anchor, 2.6-mm suture anchor) were used to reduce the reverse HAGL lesion to an anatomical position, and the posterior capsule was closed thereafter.

Results:

Only case studies and a single case series have been published pertaining to reverse HAGL repair techniques and related outcomes. When diagnosed and treated appropriately, arthroscopic repairs yield promising results with a high percentage of patients returning to prior level of activity or returning to prior participation level in sport. However, outcome data are limited given the rare occurrence of this injury pattern.

Discussion/Conclusion:

Reverse HAGL pathology can be treated effectively with arthroscopic surgical repair to restore the normal capsular anatomy and prevent recurrent instability and persistent posterior shoulder pain. Using a 2-portal approach with posterior capsular closure is a minimally invasive operation that allows for appropriate management of these rare injuries.

Patient Consent Disclosure Statement:

The author(s) attests that consent has been obtained from any patient(s) appearing in this publication. If the individual may be identifiable, the author(s) has included a statement of release or other written form of approval from the patient(s) with this submission for publication.
Human Visual Attention Mechanism-Inspired Point-and-Line Stereo Visual Odometry for Environments with Uneven Distributed Features
Authors: Wang Chang , Zhang Jianhua , Zhao Yan , Zhou Youjie , Jiang Jincheng
Published: May 2023

Visual odometry is critical in visual simultaneous localization and mapping for robot navigation. However, the pose estimation performance of most current visual odometry algorithms degrades in scenes with unevenly distributed features because dense features occupy excessive weight. Herein, a new human visual attention mechanism for point-and-line stereo visual odometry, which is called point-line-weight-mechanism visual odometry (PLWM-VO), is proposed to describe scene features in a global and balanced manner. A weight-adaptive model based on region partition and region growth is generated for the human visual attention mechanism, where sufficient attention is assigned to position-distinctive objects (sparse features in the environment). Furthermore, the sum of absolute differences algorithm is used to improve the accuracy of initialization for line features. Compared with the state-of-the-art method (ORB-VO), PLWM-VO show a 36.79% reduction in the absolute trajectory error on the Kitti and Euroc datasets. Although the time consumption of PLWM-VO is higher than that of ORB-VO, online test results indicate that PLWM-VO satisfies the real-time demand. The proposed algorithm not only significantly promotes the environmental adaptability of visual odometry, but also quantitatively demonstrates the superiority of the human visual attention mechanism.
Traumatic peripheral nerve injuries: a classification proposal
Authors: Lavorato Andrea , Aruta Gelsomina , De Marco Raffaele , Zeppa Pietro , Titolo Paolo , Colonna Michele Rosario , Galeano Mariarosaria , Costa Alfio Luca , Vincitorio Francesca , Garbossa Diego , Battiston Bruno
Published: May 2023

Background

Peripheral nerve injuries (PNIs) include several conditions in which one or more peripheral nerves are damaged. Trauma is one of the most common causes of PNIs and young people are particularly affected. They have a significant impact on patients’ quality of life and on the healthcare system, while timing and type of surgical treatment are of the utmost importance to guarantee the most favorable functional recovery. To date, several different classifications of PNIs have been proposed, most of them focusing on just one or few aspects of these complex conditions, such as type of injury, anatomic situation, or prognostic factors. Current classifications do not enable us to have a complete view of this pathology, which includes diagnosis, treatment choice, and possible outcomes. This fragmentation sometimes leads to an ambiguous definition of PNIs and the impossibility of exchanging crucial information between different physicians and healthcare structures, which can create confusion in the choice of therapeutic strategies and timing of surgery.

Materials

The authors retrospectively analyzed a group of 24 patients treated in their center and applied a new classification for PNI injuries. They chose (a) five injury-related factors, namely nerve involved, lesion site, nerve type (whether motor, sensory or mixed), surrounding tissues (whether soft tissues were involved or not), and lesion type—whether partial/in continuity or complete. An alphanumeric code was applied to each of these classes, and (b) four prognostic codes, related to age, timing, techniques, and comorbidities.

Results

An alphanumeric code was produced, similar to that used in the AO classification of fractures.

Conclusions

The authors propose this novel classification for PNIs, with the main advantage to allow physicians to easily understand the characteristics of nerve lesions, severity, possibility of spontaneous recovery, onset of early complications, need for surgical treatment, and the best surgical approach.

Level of evidence: according to the Oxford 2011 level of evidence, level 2.
Single-cell omics traces the heterogeneity of prostate cancer cells and the tumor microenvironment
Authors: Yu Xudong , Liu Ruijia , Gao Wenfeng , Wang Xuyun , Zhang Yaosheng
Published: May 2023

Prostate cancer is one of the more heterogeneous tumour types. In recent years, with the rapid development of single-cell sequencing and spatial transcriptome technologies, researchers have gained a more intuitive and comprehensive understanding of the heterogeneity of prostate cancer. Tumour-associated epithelial cells; cancer-associated fibroblasts; the complexity of the immune microenvironment, and the heterogeneity of the spatial distribution of tumour cells and other cancer-promoting molecules play a crucial role in the growth, invasion, and metastasis of prostate cancer. Single-cell multi-omics biotechnology, especially single-cell transcriptome sequencing, reveals the expression level of single cells with higher resolution and finely dissects the molecular characteristics of different tumour cells. We reviewed the recent literature on prostate cancer cells, focusing on single-cell RNA sequencing. And we analysed the heterogeneity and spatial distribution differences of different tumour cell types. We discussed the impact of novel single-cell omics technologies, such as rich omics exploration strategies, multi-omics joint analysis modes, and deep learning models, on future prostate cancer research. In this review, we have constructed a comprehensive catalogue of single-cell omics studies in prostate cancer. This article aimed to provide a more thorough understanding of the diagnosis and treatment of prostate cancer. We summarised and proposed several key issues and directions on applying single-cell multi-omics and spatial transcriptomics to understand the heterogeneity of prostate cancer. Finally, we discussed single-cell omics trends and future directions in prostate cancer.
Mitigation of Greenhouse Gas Emissions from Rice via Manipulation of Key Root Traits
Authors: Jiménez Juan de la Cruz , Pedersen Ole
Published: May 2023

Rice production worldwide represents a major anthropogenic source of greenhouse gas emissions. Nitrogen fertilization and irrigation practices have been fundamental to achieve optimal rice yields, but these agricultural practices together with by-products from plants and microorganisms, facilitate the production, accumulation and venting of vast amounts of CO2, CH4 and N2O. We propose that the development of elite rice varieties should target root traits enabling an effective internal O2 diffusion, via enlarged aerenchyma channels. Moreover, gas tight barriers impeding radial O2 loss in basal parts of the roots will increase O2 diffusion to the root apex where molecular O2 diffuses into the rhizosphere. These developments result in plants with roots penetrating deeper into the flooded anoxic soils, producing higher volumes of oxic conditions in the interface between roots and rhizosphere. Molecular O2 in these zones promotes CH4 oxidation into CO2 by methanotrophs and nitrification (conversion of NH4+ into NO3-), reducing greenhouse gas production and at the same time improving plant nutrition. Moreover, roots with tight barriers to radial O2 loss will have restricted diffusional entry of CH4 produced in the anoxic parts of the rhizosphere and therefore plant-mediated diffusion will be reduced. In this review, we describe how the exploitation of these key root traits in rice can potentially reduce greenhouse gas emissions from paddy fields.
Effects of a realistic pesticide spraying sequence for apple crop on stream communities in mesocosms: negligible or notable?
Authors: Mohr Silvia , Meinecke Stefan , Feibicke Michael , Duquesne Sabine , Frische Tobias , Sahm René
Published: May 2023

Background

Several large-scale studies revealed impacts and risks for aquatic communities of small rural lakes and streams due to pesticides in agricultural landscapes. It appears that pesticide risk assessment based on single products does not offer sufficient protection for non-target organisms, which are exposed repeatedly to pesticide mixtures in the environment. Therefore, a comprehensive stream mesocosm study was conducted in order to investigate the potential effects of a realistic spraying sequence for conventional orchard farmed apples on a stream community using pesticides at their regulatory acceptable concentrations (RACs). Eight 74-m-long stream mesocosms were established with water, sand, sediment, macrophytes, plankton and benthic macroinvertebrates. In total, nine fungicidal, four herbicidal and four insecticidal pesticides were applied in four of the eight stream mesocosms on 19 spraying event days in the period from April to July while the remaining four stream mesocosms served as controls. The community composition, the abundance of benthos, periphyton and macrophytes, the emergence of insects, physico-chemical water parameters, and drift measurements of aquatic invertebrates were measured.

Results

The pesticide spraying sequence induced significant effects on invertebrates, periphyton, and macrophytes as well as on the water ion composition especially in the second half of the experiment. It was not possible to relate the observed effects on the community to specific pesticides applied at certain time points and their associated toxic pressure using the toxic unit approach. The most striking result was the statistically significant increase in variation of population response parameters of some taxa in the treated mesocosms compared to the controls. This inter-individual variation can be seen as a general disturbance measure for the ecosystem.

Conclusions

The pesticide spraying sequence simulated by using RAC values had notable effects on the aquatic stream community in the conducted mesocosm study. The results indicate that the current risk assessment for pesticides may not ensure a sufficient level of protection to the field communities facing multiple pesticide entries due to spraying sequences and other combined stress. Hence, there is still room for improvement regarding the prospective risk assessment of pesticides to further reduce negative effects on the environment.
SIMplyBee: an R package to simulate honeybee populations and breeding programs
Authors: Obšteter Jana , Strachan Laura K. , Bubnič Jernej , Prešern Janez , Gorjanc Gregor
Published: May 2023

Background

The Western honeybee is an economically important species globally, but has been experiencing colony losses that lead to economical damage and decreased genetic variability. This situation is spurring additional interest in honeybee breeding and conservation programs. Stochastic simulators are essential tools for rapid and low-cost testing of breeding programs and methods, yet no existing simulator allows for a detailed simulation of honeybee populations. Here we describe SIMplyBee, a holistic simulator of honeybee populations and breeding programs. SIMplyBee is an R package and hence freely available for installation from CRAN http://cran.r-project.org/package=SIMplyBee.

Implementation

SIMplyBee builds upon the stochastic simulator AlphaSimR that simulates individuals with their corresponding genomes and quantitative genetic values. To enable honeybee-specific simulations, we extended AlphaSimR by developing classes for global simulation parameters, , for a honeybee colony, , and multiple colonies, . We also developed functions to address major honeybee specificities: honeybee genome, haplodiploid inheritance, social organisation, complementary sex determination, polyandry, colony events, and quantitative genetics at the individual- and colony-levels.

Results

We describe its implementation for simulating a honeybee genome, creating a honeybee colony and its members, addressing haplodiploid inheritance and complementary sex determination, simulating colony events, creating and managing multiple colonies at the same time, and obtaining genomic data and honeybee quantitative genetics. Further documentation, available at http://www.SIMplyBee.info, provides details on these operations and describes additional operations related to genomics, quantitative genetics, and other functionalities.

Discussion

SIMplyBee is a holistic simulator of honeybee populations and breeding programs. It simulates individual honeybees with their genomes, colonies with colony events, and individual- and colony-level genetic and breeding values. Regarding the latter, SIMplyBee takes a user-defined function to combine individual- into colony-level values and hence allows for modeling any type of interaction within a colony. SIMplyBee provides a research platform for testing breeding and conservation strategies and their effect on future genetic gain and genetic variability. Future developments of SIMplyBee will focus on improving the simulation of honeybee genomes, optimizing the simulator’s performance, and including spatial awareness in mating functions and phenotype simulation. We invite the honeybee genetics and breeding community to join us in the future development of SIMplyBee.
Campylobacter prevalence from food, animals, human and environmental samples in Iran: a systematic review and meta-analysis
Authors: Ansarifar Elham , Riahi Seyed Mohamad , Tasara Taurai , Sadighara Parisa , Zeinali Tayebeh
Published: May 2023

Background

Campylobacterregarded as a major cause of foodborne gastroenteritis in humans. The present study aimed to determine the prevalence ofcampylobacterin food, animal and human samples of Iran.

Results

Quantitative synthesis was performed from 119 articles. White meat had the highest pooled prevalence ofCampylobacterspp. (43.9%). Pooled prevalence of 7.9% and 5.5% forCampylobacter, respectively, were determined for red meat and eggs from Iran.Campylobacterwas seen in 14.9% of environmental samples and 8.4% of human samples. In most of the samplesC. jejunihad higher frequency thanC. coli.Most of the isolatedCampylobacterharbored several of the known virulence related genes of this pathogen.

Conclusion

Chicken was identified as theCampylobacterreservoir. As such preventive strategies in all stages of poultry production until consumption are necessary to control foodborne human infection with Campylobacter in Iran.
Neurophysiological visual assessment in patients with idiopathic intracranial hypertension: visual evoked potential and multifocal field electroretinography
Authors: Elgaly Marwa A. , Hosny Hanan , El Habashy Hala R. , Hussein Mona , Magdy Rehab , Elanwar Rehab
Published: May 2023

Background

Determining the cause of visual deterioration in idiopathic intracranial hypertension (IIH) patients is of clinical necessity. This study aimed to study the effect of chronic increased ICP on the retina and optic nerve through objective electrophysiological measures in chronic IIH patients.

Methods

Thirty patients with chronic IIH and thirty age and sex-matched healthy controls were included in this study. Papilledema grade and CSF pressure were evaluated in the patients’ group. Both groups were submitted to visual evoked potentials (VEP) and multifocal electroretinogram (mfERG).

Result

The mean value of P100 latencies of the right and left on two check sizes, 1 deg and 15ṁ in chronic IIH patients, was significantly delayed than controls (P-value < 0.001 for each). Chronic IIH patients showed a significantly lower amplitude of the right and left R1, R2, R3, R4 & R5 compared to controls (P-value < 0.001, < 0.001) (P-value < 0.001, < 0.001) (P-value < 0.001, < 0.001) (P-value < 0.001, = 0.001) (P-value = 0.002, < 0.001), respectively. Also, patients showed a significantly delayed peak time of the right and left R1 and R2 compared to controls (P-value < 0.001, < 0.001) (P-value = 0.001, = 0.009), respectively. There was a significant positive correlation between each of CSF pressure and papilledema grade with right and left PVEP latencies. In contrast, there was no statistically significant correlation between either CSF pressure or papilledema grade and PVEP amplitudes in both eyes.

Conclusion

In chronic IIH patients, both optic nerve dysfunction and central retinal changes were identified, supported by VEP and the mfERG findings.
Effect of low-molecular-weight heparin in women undergoing frozen-thawed embryo transfer cycles: a retrospective cohort study
Authors: Sun Bo , Li Lu , Chen Xiaoli , Sun Yingpu
Published: May 2023

Background

Recurrent pregnancy loss (RPL) and recurrent implantation failure (RIF) during in vitro fertilization (IVF) treatment are still tough problems without effective treatments; thus, they are important research topics. There is controversy on whether low molecular weight heparin (LMWH) improves pregnancy outcomes in women with unexplained RPL and RIF. Moreover, currently, there is a paucity of reports on the role of LMWH in the entire population undergoing frozen-thawed embryo transfer (FET) cycles. This study aimed to estimate the effects of LMWH on pregnancy outcomes in women undergoing FET cycles.

Methods

There were 1881 female patients included in the study. Of the 1881 patients, 107 underwent preimplantation genetic diagnosis cycles, which were analyzed individually. The patients were divided into two groups: the LMWH group received injections of 4100 IU/d LMWH from the day of transfer until 14 ± 2 days posttransplant, the control group was the comparison group (without LMWH use). The baseline characteristics and reproductive outcomes of the patients were reviewed.

Results

Of the 1774 women with normal FET cycles, no significant differences were found in the number of embryos implanted (1.31 ± 0.02 vs. 1.28 ± 0.02), embryo implantation rate, biochemical pregnancy rate, clinical pregnancy rate, live birth rate, late abortion rate, and ectopic pregnancy rate between the two groups. The LMWH group had a higher early abortion (17.8% [76/427] vs. 12.5% [55/439], p = 0.030). In the sub-group analysis, among the patients who underwent more than four transfers, the LMWH group had a lower late abortion rate (1.7% [1/60] vs. 13.2% [7/53], p = 0.043). Similarly, of the 107 women who underwent preimplantation genetic diagnosis cycles, the reproductive outcomes were comparable between the two groups.

Conclusion

In the general population and PGD patients, LMWH did not improve pregnancy outcomes. Therefore, the routine use of LMWH is not recommended for early treatment.
Efficacy of resuscitative endovascular balloon occlusion of the aorta for hemorrhage control in patients with abnormally invasive placenta: a historical cohort study
Authors: Ye Yuanhua , Li Jing , Liu Shiguo , Zhao Yang , Wang Yanhua , Chu Yijing , Peng Wei , Lu Caixia , Liu Chong , Zhou Jun
Published: May 2023

Background

Patients with abnormally invasive placenta (AIP) are at high risk of massive postpartum hemorrhage. Resuscitative endovascular balloon occlusion of the aorta (REBOA), as an adjunct therapeutic strategy for hemostasis, offers the obstetrician an alternative for treating patients with AIP. This study aimed to evaluate the role of REBOA in hemorrhage control in patients with AIP.

Methods

This was a historical cohort study with prospectively collected data between January 2014 to July 2021 at a single tertiary center. According to delivery management, 364 singleton pregnant AIP patients desiring uterus preservation were separated into two groups. The study group (balloon group, n = 278) underwent REBOA during cesarean section, whereas the reference group (n = 86) did not undergo REBOA. Surgical details and maternal outcomes were collected. The primary outcome was estimated blood loss and the rate of uterine preservation.

Results

A total of 278 (76.4%) participants experienced REBOA during cesarean section. The patients in the balloon group had a smaller blood loss during cesarean Sect. (1370.5 [752.0] ml vs. 3536.8 [1383.2] ml; P < .001) and had their uterus salvaged more often (264 [95.0%] vs. 23 [26.7%]; P < .001). These patients were also less likely to be admitted to the intensive care unit after delivery (168 [60.4%] vs. 67 [77.9%]; P = .003) and had a shorter operating time (96.3 [37.6] min vs. 160.6 [45.5] min; P < .001). The rate of neonatal intensive care unit admission (176 [63.3%] vs. 52 [60.4%]; P = .70) and total maternal medical costs ($4925.4 [1740.7] vs. $5083.2 [1705.1]; P = .13) did not differ between the two groups.

Conclusions

As a robust hemorrhage-control technique, REBOA can reduce intraoperative hemorrhage in patients with AIP. The next step is identifying associated risk factors and defining REBOA inclusion criteria to identify the subgroups of AIP patients who may benefit more.
Quality of maternal and newborn health care at private hospitals in Iraq: a cross-sectional study
Authors: Tappis Hannah , Lak Rebaz , Alhilfi Riyadh , Zangana Aso Hameed , Wadi Falah , Hipgrave David , Ibrahim Shaimaa
Published: May 2023

Background

Approximately 25% of facility births take place in private health facilities. Recent national studies of maternal and newborn health (MNH) service availability and quality have focused solely on the status of public sector facilities, leaving a striking gap in information on the quality of maternal and newborn care services.

Methods

A rapid cross-sectional assessment was conducted in November 2022 to assess the quality of MNH services at private hospitals in Iraq. Multi-stage sampling was used to select 15% of the country’s 164 private hospitals. Assessment tools included a facility assessment checklist, a structured health worker interview tool, and a structured client exit interview tool. Data collection was conducted using KoboToolbox software on Android tablets, and analysis conducted using SPSS v28.

Results

All hospitals visited provided MNH services and had skilled personnel present or on-call 24 h/day, 7 days/week. Most births (88%) documented between January and June 2022 were cesarean births. Findings indicate that nearly all hospitals have the human resources, equipment, medicines and supplies necessary for quality antenatal, intrapartum and early essential newborn care, and many are also equipped with special units and resources needed to care for small and sick babies. However, while resources are in place for basic and advanced care, there are gaps in knowledge and practice of high-impact interventions that require few or no resources to perform, including skin-to-skin thermal care and support for early initiation of breastfeeding. Person-centered maternity care scores suggest that private hospitals offer a positive experience of care for all clients, however there is room for improvement in provider–client communication.

Conclusions

This assessment highlights the need for deeper dives into factors that underly decisions about how and where to give birth, and both understanding and practice of early essential newborn care and pre-discharge examinations and counseling at private healthcare facilities in Iraq. Engaging private health facility staff in efforts to monitor and improve the quality of maternal and newborn care, with a focus on early essential newborn care and provider–client communication for all clients, will ensure that women and newborns benefit from the best care possible with available resources.
Treatment of FIGO 2018 stage IIIC cervical cancer with different local tumor factors
Authors: Ye Yanna , Li Zhiqiang , Kang Shan , Yang Yongxiu , Ling Bin , Wang Li , Yao Jilong , Li Pengfei , Wang Xueqin , Gong Shipeng , Fan Huijian , Kong Yanxiang , Cao Yuye , Lang Jinghe , Liu Ping , Chen Chunlin
Published: May 2023

Background

To compare the oncological outcomes of patients with FIGO 2018 stage IIIC cervical cancer (CC) involving different local tumor factors who underwent abdominal radical hysterectomy (ARH), neoadjuvant chemotherapy and radical surgery (NACT), or radical chemoradiotherapy (R-CT).

Methods

Based on tumor staging, patients with stage IIIC were divided into T1, T2a, T2b, and T3 groups. Kaplan–Meier and Cox proportional hazards regression analysis were used to compare their overall survival (OS) and disease-free survival (DFS) of 5 years.

Results

We included 4,086 patients (1,117, 1,019, 869, and 1,081 in the T1, T2a, T2b, and T3 groups, respectively). In the T1 group, NACT was correlated with a decrease in OS (hazard ratio [HR] = 1.631, 95% confidence interval [CI]: 1.150–2.315, P = 0.006) and DFS (HR = 1.665, 95% CI: 1.255–2.182, P < 0.001) than ARH. ARH and NACT were not correlated with OS (P = 0.226 and P = 0.921) or DFS (P = 0.343 and P = 0.535) than R-CT. In the T2a group, NACT was correlated with a decrease in OS (HR = 1.454, 95% CI: 1.057–2.000, P = 0.021) and DFS (HR = 1.529, 95% CI: 1.185–1.974, P = 0.001) than ARH. ARH and NACT were not correlated with OS (P = 0.736 and P = 0.267) or DFS (P = 0.714 and P = 0.087) than R-CT. In the T2b group, NACT was correlated with a decrease in DFS (HR = 1.847, 95% CI: 1.347–2.532, P < 0.001) than R-CT nevertheless was not correlated with OS (P = 0.146); ARH was not correlated with OS (P = 0.056) and DFS (P = 0.676). In the T3 group, the OS rates of ARH (n = 10), NACT (n = 18), and R-CT (n = 1053) were 67.5%, 53.1%, and 64.7% (P = 0.941), and the DFS rates were 68.6%, 45.5%, and 61.1%, respectively (P = 0.761).

Conclusion

R-CT oncological outcomes were not entirely superior to those of NACT or ARH under different local tumor factors with stage IIIC. NACT is not suitable for stage T1, T2a, and T2b. Nevertheless ARH is potentially applicable to stage T1, T2a, T2b and T3. The results of stage T3 require confirmation through further research due to disparity in case numbers in each subgroup.
Clinical characteristics, treatment and prognosis of infants with retinoblastoma: a multicenter, 10-year retrospective analysis
Authors: Zhang Yi , Wang Yizhuo , Zhi Tian , Jin Mei , Huang Dongsheng , Ma Xiaoli
Published: May 2023

Background

To summarize the characteristics and treatment, and analyze the prognosis of large number of infants with retinoblastoma (RB) in China through a multicenter, 10-year retrospective analysis.

Methods

The data of RB infants were collected from multiple centers. The characteristics and survival prognosis were analyzed. The overall survival (OS) rate was estimated by the Kaplan–Meier method. Multivariate Cox survival analysis was to evaluate the independent risk factors affecting the prognosis of RB infants.

Results

A total of 373 RB infants (202 boys and 171 girls) were included, the median age was 6.22 months (10 days to 11.93 months). The median follow-up time of RB infants was 18.4 (1.02–122.81 months). After excluding the lost to follow-up cases, the OS rate was 97.7% (345/353). Kaplan–Meier survival analysis indicated that 9 cases died and the median survival time was not reached. Univariate analysis of prognostic factors revealed eye affected, presenting signs, left eye stage and recurrence to be poor prognostic factors for OS rate in RB infants (all P < 0.05). Multivariate Cox regression analyses for OS showed recurrence (HR = 1.376, 95% CI: 0.878–2.156, P = 0.048) was an independent factor for prognosis of infants with RB. The median survival time of infants underwent chemotherapy + intra-arterial chemotherapy (IAC) + enucleation + vitrectomy was the longest than other treatments (n = 9, 47.64 months, OS = 100%, all P < 0.05). There was a history of RB in 17 infants' lineal relatives. Kaplan-merier survival analysis indicated 1 case died and the median survival time was not reached.

Conclusion

Recurrence is an independent factor for prognosis of RB infants, which still needs attention after treatment. Early screening, comprehensive treatments and follow-up of patients may lead to improvements of prognosis of RB infants.