bluuebunny/crossref_metadata_2025 huggingface dataset:
Association between dietary fat intake and colorectal cancer: A multicenter case-control study in Iran
Authors: Seyyedsalehi Monireh Sadat , Collatuzzo Giulia , Huybrechts Inge , Hadji Maryam , Rashidian Hamideh , Safari-Faramani Roya , Alizadeh-Navaei Reza , Kamangar Farin , Etemadi Arash , Pukkala Eero , Gunter Marc J. , Chajes Veronique , Boffetta Paolo , Zendehdel Kazem
Published: November 2022

The evolving trends in colorectal cancer (CRC) as one of the most common malignancies worldwide, have likely been influenced by the implementation of screening programs and changes in lifestyle habits. Changing lifestyle, including the shift in diet composition with higher fat, sugar, and animal-source foods intake, led to an increasing burden of CRC in countries undergoing rapid socioeconomic improvement. Results for the link between specific fatty acids (FAs) and CRC are generally inconclusive and more limited in developing countries than elsewhere. This study aims to investigate the association between FA intakes and CRC and its anatomical subsites in a large Iranian case-control study. A food frequency questionnaire was used to collect information on dietary intake in 865 cases and 3206 controls. We conducted multivariate logistic regression models to calculate the odds ratio (OR) and 95% confidence interval (CI). We found positive association between CRC and high intake of dietary total fat (OR highest quartile Q4 = 1.77, 95% CI = 1.32–2.38), cholesterol (ORQ4 = 1.58, 95% CI = 1.22–2.05), and palmitoleic acid (ORQ4 = 2.16, 95% CI = 1.19, 3.91), and an inverse association with high intake of dietary heptanoic acid (ORQ4 = 0.33, 95% CI = 0.14, 0.79) and low intake of palmitic acid (OR lowest quartile Q2 = 0.53, 95% CI = 0.31–0.88). None of the fat variables were associated with rectal cancer. Our study suggests that the recommendation of limited consumption of fats may decrease the risk of CRC among the Iranian population.
Starch–protein interaction effects on lipid metabolism and gut microbes in host
Authors: Wang Kaijun , Zhou Miao , Gong Xinyu , Zhou Yuqiao , Chen Jiayi , Ma Jie , Zhang Peihua
Published: November 2022

The purpose of this experiment was to investigate the effects of different starch and protein levels on lipid metabolism and gut microbes in mice of different genders. A total of 160 male mice were randomly assigned to sixteen groups and fed a 4 × 4 Latin square design with dietary protein concentrations of 16, 18, 20, and 22%, and starch concentrations of 50, 52, 54, and 56%, respectively. The results of the study showed that different proportions of starch and protein had obvious effects on the liver index of mice, and there was a significant interaction between starch and protein on the liver index (p = 0.005). Compared with other protein ratio diets, 18% protein diet significantly increased the serum TBA concentration of mice (p < 0.001), and different starch ratio diets had no effect on serum TBA concentration (p = 0.442). It was proved from the results of ileal tissue HE staining that the low protein diet and the low starch diet were more favorable. There was a significant interaction between diets with different starch and protein levels on Bacteroidetes, Firmicutes and Proteobacteria abundance in feces of mice (p < 0.001). Compared with 16 and 18% protein ratio diets, both 20 and 22% protein diets significantly decreased the Parabacteroides and Alistipes abundance in feces of mice (p < 0.05), and 52% starch ratio diet significantly decreased the Parabacteroides and Alistipes abundance than 50% starch ratio diet of mice (p < 0.05). There was a significant interaction between diets with different starch and protein levels on Parabacteroides (p = 0.014) and Alistipes (p = 0.001) abundance in feces of mice. Taken together, our results suggest that a low protein and starch diet can alter lipid metabolism and gut microbes in mice.
Human milk nutritional composition across lactational stages in Central Africa
Authors: Moya-Alvarez Violeta , Eussen Simone R. B. M. , Mank Marko , Koyembi Jean-Christophe Junior , Nyasenu Yawo Tufa , Ngaya Gilles , Mad-Bondo Daniel , Kongoma Jean-Bertrand , Stahl Bernd , Sansonetti Philippe J. , Bourdet-Sicard Raphaëlle
Published: November 2022

The African region encompasses the highest undernutrition burden with the highest neonatal and infant mortality rates globally. Under these circumstances, breastfeeding is one of the most effective ways to ensure child health and development. However, evidence on human milk (HM) composition from African women is scarce. This is of special concern, as we have no reference data from HM composition in the context of food insecurity in Africa. Furthermore, data on the evolution of HM across lactational stages in this setting lack as well. In the MITICA study, we conducted a cohort study among 48 Central-African women and their 50 infants to analyze the emergence of gut dysbiosis in infants and describe the mother-infant transmission of microbiota between birth and 6 months of age. In this context, we assessed nutritional components in HM of 48 lactating women in Central Africa through five sampling times from week 1 after birth until week 25. Unexpectedly, HM-type III (Secretor + and Lewis genes -) was predominant in HM from Central African women, and some nutrients differed significantly among HM-types. While lactose concentration increased across lactation periods, fatty acid concentration did not vary significantly. The overall median level of 16 detected individual human milk oligosaccharides (HMOs; core structures as well as fucosylated and sialylated ones) decreased from 7.3 g/l at week 1 to 3.5 g/l at week 25. The median levels of total amino acids in HM dropped from 12.8 mg/ml at week 1 to 7.4 mg/ml at week 25. In contrast, specific free amino acids increased between months 1 and 3 of lactation, e.g., free glutamic acid, glutamine, aspartic acid, and serine. In conclusion, HM-type distribution and certain nutrients differed from Western mother HM.
Multiple health risk behaviors, including high consumption of ultra-processed foods and their implications for mental health during the COVID-19 pandemic
Authors: Coletro Hillary Nascimento , Mendonça Raquel de Deus , Meireles Adriana Lúcia , Machado-Coelho George Luiz Lins , Menezes Mariana Carvalho de
Published: November 2022

Background and aim

The growing increase in diet- and behavior-related illnesses has drawn the attention of many epidemiologists who attribute such changes to the epidemiological and nutritional transition. Thus, this study aims to evaluate the association between the combined occurrence of health risk behaviors, such as sedentary lifestyles, high weekly consumption of ultra-processed foods (UPFs), and non-daily consumption of fruits and vegetables, and symptoms of anxiety or depression in adults.

Methods

This is a cross-sectional study based on an epidemiological survey in two Brazilian cities. The outcome, anxiety, and depression symptoms were assessed using the Generalized Anxiety Disorder 7-item (GAD-7) and the Patient Health Questionnaire-9 (PHQ-9). Food consumption was assessed using a qualitative food frequency questionnaire (FFQ) with reference to consumption in the last 3 months and categorized into the consumption of fruits and vegetables and the consumption of UPFs according to the NOVA classification. Sedentary behavior was assessed by considering the amount of sitting or reclining time per day reported by participants and categorized as less than 9 h of sitting or reclining and 9 h or more. For the analysis, adjusted Poisson regression (PR) was used to estimate the prevalence ratio and the 95% confidence interval (CI).

Results

Those with the health risk behaviors, non-daily consumption of fruits and vegetables, and high consumption of UPFs had a 2.6 higher prevalence ratio for symptoms of mental disorder (PR: 2.6 and 95%CI: 1.1–6.5), as well as those with all three health risk behaviors, had a 2.8 higher prevalence ratio for symptoms of mental disorder (PR: 2.8 and 95%CI: 1.3–6.1).

Conclusion

This study revealed that the existence of a combination of two and three health risk behaviors led to a higher prevalence of symptoms of anxiety or depression.
Deciphering the impact and mechanism of Trikatu, a spices-based formulation on alcoholic liver disease employing network pharmacology analysis and in vivo validation
Authors: Sharma Ruchi , Jadhav Mangala , Choudhary Neha , Kumar Arun , Rauf Abdur , Gundamaraju Rohit , AlAsmari Abdullah F. , Ali Nemat , Singla Rajeev K. , Sharma Rohit , Shen Bairong
Published: November 2022

Trikatu Churna (TC) comprising Zingiber officinale rhizome, Piper longum, and Piper nigrum fruit, is effective in treating liver diseases and has high nutraceutical values. However, the efficacy of TC in treating alcoholic liver disease (ALD) and its mechanism remain largely unknown. This study evaluated the hepatoprotective effects of different doses of TC as well as to identify the bioactive components and determine their mechanism of action against ethanol-induced ALD. A compound-target network analysis model of TC was established to identify its potential bioactive compounds and pathways that might regulate its hepatoprotective effects. Further, in-vivo studies were performed to validate the potential of TC (200 mg/kg and 400 mg/kg b.w.) in the treatment and management of ALD. The study revealed that both the dosages of TC demonstrate significant (p > 0.0001) hepatoprotective effects by improving body weight, total bilirubin, serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), serum alkaline phosphate (ALP), total cholesterol, total protein, globulin, albumin, and liver morphology. The High-performance thin-layer chromatography (HPTLC) fingerprinting of TC showed the presence of piperine. Network pharmacology identifies the role of TC in regulating various signaling processes including Advanced glycation end products-receptor for advanced glycation end products (AGE-RAGE), Hypoxia-inducible factors (HIF-1), Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-Kappa B), and Phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling to exert its anti-inflammatory, antioxidant and anti-apoptotic role in managing ALD. Based on the bioinformatics analysis, some of the key targets of TC were found to be Prostaglandin-Endoperoxide Synthase 2 (PTGS2) or Cyclooxygenase-2 (COX-2), Sirtuin 1 (SRT1), and caspase-3. These effects may serve as a novel therapeutic option for the treatment of ALD. These preclinical validation studies for the ethnopharmacological potential of TC in ALD treatment further paved the way for researchers to perform next-level translational and clinical studies. Further, in-depth experimental studies for the validation of these bioinformatics-based results will give a clearer picture of mechanisms.
The feasibility and safety of simultaneous bilateral video-assisted thoracic surgery for the treatment of bilateral pulmonary lesions
Authors: Tao Xiandong , Zhao Jiannan , Wei Wei , Shan Zhengxiang , Zheng Hongyang , Pan Tiewen
Published: November 2022

Background

The aim of this study was to evaluate the feasibility and safety of simultaneous bilateral video-assisted thoracic surgery (VATS) for the treatment of bilateral pulmonary lesions.

Methods

The data of 11 patients who received simultaneous bilateral pulmonary surgery using VATS in the Department of Thoracic Surgery of The Third Affiliated Hospital of Naval Medical University between January 2016 and August 2021 were retrospectively analyzed.

Results

The cases of four male and seven female patients, with a mean age of 57.54 ± 8.37 years (range, 44-67 years), were reviewed. Nonanatomic wedge resection, pulmonary segmentectomy or lobectomy via VATS were performed depending on each patient’s situation. Mean 1 second forced expiratory volume (FEV1) was 2.55 ± 0.66 L(range, 1.49-3.88 L), mean intraoperative bleeding volume was 91.81 ± 49.56 mL(range, 30-150 mL), mean operating time was 273.72 ± 68.98 min(range, 132-390 min), and mean drainage duration was 5.27 ± 3.60 days(range, 2-14 days), with a mean total drainage volume of 1,515.90 ± 772.75 mL(range, 530-3,225 mL). Only one postoperative complication (air leakage) occurred, with an overall complication rate of 9.09%. The mean postoperative hospital stay was 8.81 ± 3.60 days (range, 5-18 days), and the mean total cost of hospitalization was 67,054.53 ± 20,896.49 RMB (range, 47,578.45-123,530.8 RMB).

Conclusions

Simultaneous bilateral pulmonary surgery using VATS for the treatment of bilateral pulmonary lesions is safe and feasible and can therefore be considered after strict preoperative evaluation of the patient.
Infantile epileptic spasms syndrome as an initial presentation in infantile choroid plexus papilloma: A case report
Authors: Zhou Faliang , Li Yu , Shen Lixue , Yao Hongxin , Hou Xinlin
Published: November 2022

We present an interesting report of a 5-month-old infant with epileptic spasms and developmental delay who presented with non-isolated ventriculomegaly in utero and whose brain magnetic resonance imaging revealed right ventricular choroid plexus papilloma (CPP). The epileptic spasms persisted even with the use of antiepileptic therapies but was apparently cured after the removal of a CPP.
RETRACTED: Measure and evaluate the hydrothermal flow of a Newtonian fluid in homogeneous permeable media equipped with a fin: A numerical approach
Authors: Bilal Sardar , Khan Noor Zeb , Riaz Arshad , Alyami Maryam Ahmed , El-Din ElSayed M. Tag
Published: November 2022

This study envisions the hydrothermal characteristics of a viscous fluid in a homogenously permeable hexagonal enclosure. Permeability aspects in the flow domain are described by employing the Brinkman-extended Darcy law. A corrugated hexagonal enclosure along with the placement of a star-shaped fin is taken into account. Heated rectangular blocks at horizontal extremities are installed, and sliding sides of the enclosure are considered to be cold to provide convective potential to the flow. In addition, adjoining portions of the heated rectangular blocks are supposed to be adiabatic. The dimensionless governing equations of the resultant problem are derived initially and then solved numerically by implementing the Galerkin finite element approach, and COMSOL is obliged. For this purpose, first, domain discretization is demonstrated in view of 2D elements by performing hybridized meshing. Then, the system of non-linear equations is resolved by a non-linear solver (PARADISO). The grid convergence test is performed to confirm the credibility of the carried out simulations by calculating the average Nusselt number at different refinement levels. A change in associated distributions against the involved physical parameters (Darcy number (Da), Rayleigh number (Ra), and Prandtl number (Pr)) for a wide range is revealed through graphs and tables. Quantities like kinetic energy and heat flux (local and average) are also evaluated through concerned parameters. The results clearly demonstrate that the Darcy number tends to reduce the heat transfer rate. In particular, it is depicted that by increasing the Rayleigh number (Ra), strengthening in the temperature potential arises in the system, thereby magnifying the heat transfer rate. Moreover, it is disclosed that by reducing the Darcy number, kinetic energy shows a decreasing trend.
Efficient virus-mediated genome editing in cotton using the CRISPR/Cas9 system
Authors: Lei Jianfeng , Li Yue , Dai Peihong , Liu Chao , Zhao Yi , You Yangzi , Qu Yanying , Chen Quanjia , Liu Xiaodong
Published: November 2022

Plant virus-mediated sgRNA delivery and expression have great advantages; sgRNA expression can rapidly expand and accumulate along with virus replication and movement, resulting in efficient gene editing efficiency. In this study, a VIGE system based on cotton leaf crumple virus (CLCrV) was established using cotton overexpressing Cas9 (Cas9-OE) as the VIGE receptor. CLCrV-mediated VIGE could not only target and knock out the GhMAPKKK2, GhCLA1 and GhPDS genes subgroup A and D genome sequences but also achieve double mutation of GhCLA1 and GhPDS genes at the same time. These results verified the effectiveness and efficiency of this system. In addition, the off-target effect assay demonstrated that the CLCrV-mediated VIGE system not only has high gene editing efficiency but also high gene editing specificity in cotton. We further explored whether the FT-sgRNA strategy could transport sgRNA to cotton apical meristem (SAM) over long distances to avoid using tissue culture to obtain stable genetic mutants. The results showed that the sgRNA fused with FT mRNA at the 5’ end could also efficiently achieve targeted editing of endogenous genes in cotton, but it was difficult to detect heritable mutant progeny. The above results showed that the CLCrV-mediated VIGE system provided an accurate and rapid validation tool for screening effective sgRNAs in cotton.
‘Root of all success’: Plasticity in root architecture of invasive wild radish for adaptive benefit
Authors: Bhattacharya Samik , Gröne Franziska , Przesdzink Felix , Ziffer-Berger Jotham , Barazani Oz , Mummenhoff Klaus , Kappert Niels
Published: November 2022

Successful plant establishment in a particular environment depends on the root architecture of the seedlings and the extent of edaphic resource utilization. However, diverse habitats often pose a predicament on the suitability of the fundamental root structure of a species that evolved over a long period. We hypothesized that the plasticity in the genetically controlled root architecture in variable habitats provides an adaptive advantage to worldwide-distributed wild radish (Raphanus raphanistrum, Rr) over its close relative (R. pugioniformis, Rp) that remained endemic to the East Mediterranean region. To test the hypothesis, we performed a reciprocal comparative analysis between the two species, growing in a common garden experiment on their native soils (Hamra/Sandy for Rr, Terra Rossa for Rp) and complementary controlled experiments mimicking the major soil compositions. Additionally, we analyzed the root growth kinetics via semi-automated digital profiling and compared the architecture between Rr and Rp. In both experiments, the primary roots of Rr were significantly longer, developed fewer lateral roots, and showed slower growth kinetics than Rp. Multivariate analyses of seven significant root architecture variables revealed that Rr could successfully adapt to different surrogate growth conditions by only modulating their main root length and number of lateral roots. In contrast, Rp needs to modify several other root parameters, which are very resource-intensive, to grow on non-native soil. Altogether the findings suggest an evo-devo adaptive advantage for Rr as it can potentially establish in various habitats with the minimal tweak of key root parameters, hence allocating resources for other developmental requirements.
A meta-quantitative trait loci analysis identified consensus genomic regions and candidate genes associated with grain yield in rice
Authors: Aloryi Kelvin Dodzi , Okpala Nnaemeka Emmanuel , Amo Aduragbemi , Bello Semiu Folaniyi , Akaba Selorm , Tian Xiaohai
Published: November 2022

Improving grain yield potential in rice is an important step toward addressing global food security challenges. The meta-QTL analysis offers stable and robust QTLs irrespective of the genetic background of mapping populations and phenotype environment and effectively narrows confidence intervals (CI) for candidate gene (CG) mining and marker-assisted selection improvement. To achieve these aims, a comprehensive bibliographic search for grain yield traits (spikelet fertility, number of grains per panicle, panicles number per plant, and 1000-grain weight) QTLs was conducted, and 462 QTLs were retrieved from 47 independent QTL research published between 2002 and 2022. QTL projection was performed using a reference map with a cumulative length of 2,945.67 cM, and MQTL analysis was conducted on 313 QTLs. Consequently, a total of 62 MQTLs were identified with reduced mean CI (up to 3.40 fold) compared to the mean CI of original QTLs. However, 10 of these MQTLs harbored at least six of the initial QTLs from diverse genetic backgrounds and environments and were considered the most stable and robust MQTLs. Also, MQTLs were compared with GWAS studies and resulted in the identification of 16 common significant loci modulating the evaluated traits. Gene annotation, gene ontology (GO) enrichment, and RNA-seq analyses of chromosome regions of the stable MQTLs detected 52 potential CGs including those that have been cloned in previous studies. These genes encode proteins known to be involved in regulating grain yield including cytochrome P450, zinc fingers, MADs-box, AP2/ERF domain, F-box, ubiquitin ligase domain protein, homeobox domain, DEAD-box ATP domain, and U-box domain. This study provides the framework for molecular dissection of grain yield in rice. Moreover, the MQTLs and CGs identified could be useful for fine mapping, gene cloning, and marker-assisted selection to improve rice productivity.
Screening of short-day onions for resistance to Stemphylium leaf blight in the seed-to-bulb stage (stage I) and bulb-to-seed stage (stage II)
Authors: Chandel Rahul , Kamil Deeba , Singh Shrawan , Kumar Amrender , Patel Rumit , Verma Priyanka , Zimik Masochon , Khar Anil
Published: November 2022

Stemphyliumleaf blight, caused byStemphylium vesicarium, is a very important fungal disease in onions since its epidemics are able to affect both the bulb yield and the seed quality. The aim of this study was to screen onion genotypes at stage I (seed to bulb) and further screen the identified resistant and susceptible genotypes at stage II (bulb to seed). One hundred and fifty-seven genotypes were screened against SLB under artificially inoculated field conditions. Results revealed a significant variation among the morphological and biochemical traits studied. Correlation studies revealed a significant and negative correlation between percent disease incidence (PDI), pseudostem width, neck thickness, and dry matter. Fifteen genotypes were identified as moderately resistant, and the rest were categorized as susceptible. Bulbs of the genotypes, identified as moderately resistant, were again screened for resistance in stage II. All the genotypes were categorized as moderately susceptible. Biochemical analysis revealed that total foliar phenol content, pyruvic acid, catalase, and peroxidase increased up to 20 days after inoculation (DAI) and thereafter declined. Protein content was highest in the initial stage and declined at 10, 20, and 30 DAI. The higher biochemical activity was observed in moderately resistant category genotypes compared with the susceptible ones. Correlation analysis showed a highly significant and negative correlation of PDI with total foliar phenol content (TFPC), pyruvic acid, catalase, peroxidase, and protein content. To conclude, it was observed that screening against SLB should be done at both the stages (stage I and Stage II) to identify resistant onion genotypes. Direction selection for genotypes with high dry matter, higher phenols, and enzymes may be an alternative pathway to select genotypes for a robust resistance breeding program.
Contrasting distribution of enzyme activities in the rhizosphere of European beech and Norway spruce
Authors: Song Bin , Razavi Bahar S. , Pena Rodica
Published: November 2022

Recent policies and silvicultural management call for forest regeneration that involve the selection of tree species able to cope with low soil nutrient availability in forest ecosystems. Understanding the impact of different tree species on the rhizosphere processes (e.g., enzyme activities) involved in nutrient mobilisation is critical in selecting suitable species to adapt forests to environmental change. Here, we visualised and investigated the rhizosphere distribution of enzyme activities (cellobiohydrolase, leucine-aminopeptidase, and acid phosphomonoesterase) using zymography. We related the distribution of enzyme activities to the seedling root morphological traits of European beech (Fagus sylvatica) and Norway spruce (Picea abies), the two most cultivated temperate tree species that employ contrasting strategies in soil nutrient acquisition. We found that spruce showed a higher morphological heterogeneity along the roots than beech, resulting in a more robust relationship between rhizoplane-associated enzyme activities and the longitudinal distance from the root apex. The rhizoplane enzyme activities decreased in spruce and increased in beech with the distance from the root apex over a power-law equation. Spruce revealed broader rhizosphere extents of all three enzymes, but only acid phosphomonoesterase activity was higher compared with beech. This latter result was determined by a larger root system found in beech compared with spruce that enhanced cellobiohydrolase and leucine-aminopeptidase activities. The root hair zone and hair lengths were significant variables determining the distribution of enzyme activities in the rhizosphere. Our findings indicate that spruce has a more substantial influence on rhizosphere enzyme production and diffusion than beech, enabling spruce to better mobilise nutrients from organic sources in heterogeneous forest soils.
How does artificial intelligence empower EFL teaching and learning nowadays? A review on artificial intelligence in the EFL context
Authors: Jiang Ruihong
Published: November 2022

The booming Artificial Intelligence (AI) provides fertile ground for AI in education. So far, few reviews have been deployed to explore how AI empowers English as Foreign Language (EFL) teaching and learning. This study attempts to give a brief yet profound overview of AI in the EFL context by summarizing and delineating six dominant forms of AI application, including Automatic Evaluation Systems, Neural Machine Translation Tools, Intelligent Tutoring Systems (ITSs), AI Chatting Robots, Intelligent Virtual Environment, and Affective Computing (AC) in ITSs. The review furthermore uncovers a current paucity of research on applying AC in the EFL context and exploring pedagogical and ethical implications of AI in the EFL context. Ultimately, challenges from technical and teachers' perspectives, as well as future research directions, are illuminated, hopefully proffering new insights for the future study.
Have a good day! An experience-sampling study of daily meaningful and pleasant activities
Authors: Kreiss Christoph , Schnell Tatjana
Published: November 2022

We organize our daily lives with a relatively high degree of freedom. Some things must be done; others are optional. Some we find meaningful, some pleasant, some both, and some neither. The present study looks at such evaluations of daily activities and how they relate to perceived meaning in life. Sixty-two students from an Austrian university first completed the meaningfulness scale from the Sources of Meaning and Meaning in Life Questionnaire (SoMe). They then participated in a 1-week experience-sampling assessment, wherein they completed a short questionnaire at five random time-points per day. They indicated their current activity and then reported, on a 6-point Likert scale, how pleasant and meaningful they perceived it to be. Activities could thus be categorized as meaningful, pleasant, both, or neither. Results reflected that activities grouped under culture/music, communication, intimacy, and sports are experienced as both highly meaningful and pleasant. A two-level hierarchical linear regression suggested that people with high trait meaningfulness experience their daily activities as more meaningful than people with lower trait meaningfulness if they also enjoy what they are doing. People with low trait meaningfulness, however, tended to experience their daily activities as rather meaningless, even if they enjoyed them very much. Thus, when looking for advice on how to have a good day, clarifying one’s meaning in life seems to represent the best starting point.
Experiences of intensive care unit nurses working with COVID-19 patients: A systematic review and meta-synthesis of qualitative studies
Authors: Nikbakht Nasrabadi Alireza , Abbasi Soheila , Mardani Abbas , Maleki Maryam , Vlaisavljevic Zeljko
Published: November 2022

Objectives

Intensive Care Unit (ICU) nurses are at the forefront of fighting and treating the Coronavirus 2019 (COVID-19) pandemic and are often directly exposed to this virus and at risk of disease, due to their direct care for infected patients. This study aims to synthesize the experiences of ICU nurses working with COVID-19 patients.

Methods

A systematic review and meta-synthesis of qualitative studies were undertaken. A systematic literature search in four databases, including Web of Sciences, Scopus, Embase, and PubMed (including Medline), was performed. Original qualitative studies and the qualitative section of mixed method studies, written in English, which focused on the experiences of only ICU nurses working with COVID-19 patients, were included.

Results

Seventeen qualitative studies and two mixed-method studies were included in the review. As a result of the inductive content analysis, six main categories were identified, as follows: “distance from holistic nursing,” “psychosocial experiences,” “efforts for self-protection and wellbeing,” “organizational inefficiency,” “job burnout,” and “emerging new experiences in the workplace.”

Conclusions

The findings from this study suggest that healthcare authorities and policymakers can facilitate the provision of high-quality patient care during the COVID-19 pandemic through appropriate planning to provide adequate support and training, prevent shortages of nursing staff and equipment, and provide adequate attention to the psychological needs and job satisfaction of ICU nurses.

Systematic review registration

https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=256070, identifier: CRD42021256070.
Socioeconomic correlates of face mask use among pedestrians during the COVID-19 pandemic: An ecological study
Authors: Rahimi Zahra , Mohammadi Mohammad Javad , Araban Marzieh , Shirali Gholam Abbas , Cheraghian Bahman
Published: November 2022

Background

Many countries have recommended using face masks for the general population in public places to reduce the risk of COVID-19 transmission. This study aimed to assess the effects of socioeconomic status on face mask use among pedestrians during the COVID-19 pandemic.

Methods

This cross-sectional study was conducted in Ahvaz, southwest Iran in August 2020. A total of 10,440 pedestrians have been studied from 92 neighborhoods of the city. Three socioeconomic indicators including Land price, Literacy rate, and the Employment rate for each neighborhood were used in this study. Analysis of Covariance and partial correlation coefficients were applied to assess the relationship between prevalence rates of mask usage and SES indicators.

Results

The mean ± SD age of the pedestrians was 32.2 ± 15.1 years. Of 10,440 observed participants, 67.9% were male. The overall prevalence of face mask usage was 45.6%. The prevalence of mask usage in older people and women was significantly higher than the others. The three assessed socioeconomic indicators were directly correlated to the prevalence of mask usage at individual and neighborhood levels.

Conclusion

We found that literacy had the strongest correlation with the prevalence of mask usage compared to the land price and employment rate among the three assessed SES indicators. Hence, it can be concluded that the social component of socioeconomic status has a greater effect on mask usage by people than the economic component of socioeconomic status.
Improving curriculum delivery: Using a results informed quality improvement model for teen behavioral health education
Authors: Gross Gregory , Ling Rui , Richardson Brad
Published: November 2022

Adolescence is a critical developmental stage to establish healthy decision-making processes and behavior patterns. Many interventions such as evidence-based curricula have been implemented to guide adolescents to avoid risk-taking behaviors and improve health and medical knowledge and outcomes. This study presents a participatory approach informed by the three-stage (3S) quality improvement process model to improve the quality of curriculum delivery, based on the results indicating outcomes achieved, needs for improvement, and quality assurance for maintaining the expected outcomes of an evidence-based curricula. Tests were conducted before and after the intervention. Using threshold levels and measures of change in the tests, instructors participated in guided discussion and analysis of the data to identify where and how instructional improvements should be made and where outcomes were being achieved as expected. This method was used to diagnose variation in the results and delivery and identify root causes informing actions to improve curriculum delivery and outcomes. After the facilitated discussions, pre- and post-tests from subsequent classes were analyzed. The results showed improved test item scores ranging from 2 to 69.5% and seven of 18 items obtained statistical significance following the implementation of the model described. Overall, an increase in the mean percent correct of 17.1% was found.
Lowering COVID-19 vaccine hesitancy among immigrants in Norway: Opinions and suggestions by immigrants
Authors: Kour Prabhjot , Gele Abdi , Aambø Arild , Qureshi Samera A. , Sheikh Naima Said , Vedaa Øystein , Indseth Thor
Published: November 2022

Even though COVID-19 vaccine has been proved effective, vaccine uptake and coverage has been and still is a great concern across different immigrant groups. Vaccine hesitancy remains a barrier to accept the vaccine among immigrants across the globe—including Norway—despite higher rates of hospitalizations and deaths. This study aimed to explore the opinions and suggestions of immigrants on how to lower the COVID-19 vaccine hesitancy among immigrants in Norway. Qualitative interviews were conducted with 88 persons with different immigrant background. Data was analyzed using framework analysis, utilizing “3Cs model of vaccine hesitancy” as a theoretical framework. The analysis yielded five main themes related to factors that may lower the vaccine hesitancy among immigrants in Norway: (1) Effective cultural communication, (2) Vaccine advocacy through community engagement, (3) Motivating factors, (4) Collaborative efforts via government and healthcare, and (5) Incentives for vaccination. This study enhanced our understanding of factors that according to immigrants themselves may lower the vaccine hesitancy. The insights obtained in this study can contribute to a better understanding of the current status of vaccine uptake among immigrants and can further give directions on how to improve vaccine uptake in these groups in Norway.
Use of non-invasive neurostimulation for rehabilitation in functional movement disorders
Authors: Grippe Talyta , Desai Naaz , Arora Tarun , Chen Robert
Published: November 2022

Functional movement disorders (FMD) are a subtype of functional neurological disorders which involve abnormal movements and include multiple phenomenologies. There is a growing interest in the mechanism, diagnosis, and treatment of these disorders. Most of the current therapeutic approaches rely on psychotherapy and physiotherapy conducted by a multidisciplinary team. Although this approach has shown good results in some cases, FMD cause a great burden on the health system and other treatment strategies are urgently needed. In this review, we summarize past studies that have applied non-invasive neurostimulation techniques, such as transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS) and peripheral nerve stimulation as a treatment for FMD. There is an increasing number of studies related to TMS including randomized controlled trials; however, the protocols amongst studies are not standardized. There is only preliminary evidence for the efficacy of non-invasive neuromodulation in reducing FMD symptoms, and further studies are needed. There is insufficient evidence to allow implementation of these techniques in clinical practice.
Matrix-assisted laser desorption/ionization analysis of the brain proteome of microgravity-exposed mice from the International Space Station
Authors: Vigil Correy , Daubenspeck April , Coia Heidi , Smith Jerremy , Mauzy Camilla
Published: November 2022

Manned spaceflight exposes humans to extreme environmental conditions, including microgravity exposures. The effects of microgravity during spaceflight could lead to changes in brain structure, gene expression, and vascular physiology. Given the known physiological effects, it is highly likely that there are microgravity-initiated proteomic differentials in the brain, possibly domain specific. MALDI-TOF (matrix-assisted laser desorption/ionization time of flight) Imaging Mass Spectrometry allows the visualization of the spatial distribution of highly abundant intact proteins in tissue specimens. This study utilized this technique to visualize global proteomic changes induced by microgravity exposure in brain tissue received from the Rodent Research-1 Center for the Advancement of Science in Space (CASIS)/National Aeronautics and Space Administration (NASA). Proteome profiles were obtained from isolated whole brain tissue from microgravity exposed, Habitat control, and baseline. While a total of 135 mass peaks equating to individual proteins were identified, statistical analysis determined that there were no significant differences in the spectra profiles from the three test groups utilizing this methodology, possibly due to sample collection logistics rather than lack of cellular response.
A review on irrigation parameterizations in Earth system models
Authors: Valmassoi Arianna , Keller Jan D.
Published: November 2022

Irrigation is the process of artificially providing water to agricultural lands in order to provide crops with the necessary water supply to ensure or foster the growth of the plants. However, its implications reach beyond the agro-economic aspect as irrigation affects the soil-land-atmosphere interactions and thus influences the water and energy cycles in the Earth system. Past studies have shown how through these interactions, an increase in soil moisture due to irrigation also affects the atmospheric state and its dynamics. Thus, the lack of representation of irrigation in numerical Earth system models—be it for reanalysis, weather forecasting or climate prediction—can lead to significant errors and biases in various parameters of the system including but not limited to surface temperature and precipitation. In this study, we aim to summarize and discuss currently available irrigation parameterizations across different numerical models. This provides a reference framework to understand the impact of irrigation on the various components of Earth system models. Specifically, we discuss the impact of these parameterizations in the context of their spatio-temporal scale representation and point out the benefits and limitations of the various approaches. In fact, most of the parameterizations use irrigation as a direct modification of soil moisture with just a few implementations add irrigation as a form of surface water. While the former method might be suitable for coarse spatio-temporal scales, the latter better resembles the range of employed irrigation techniques. From the analysis, we find that not only the method or the spatio-temporal scales but the actual amount of water used is of great importance to the response of the Earth system model.
Do Not Croak! A Story of Surviving Yellowstone’s Frigid Winters
Authors: Cram Jana , Rasmussen Ashelee , Patla Debra , Ray Andrew , Peterson Charles
Published: November 2022

Have you ever wondered how “cold-blooded” animals like amphibians (frogs, toads, and salamanders) survive the winter without fur or feathers to keep them warm? Yellowstone National Park’s amphibians have found ways to stay alive during the cold winter months. These animals have evolved various coping strategies, from burrowing underground, to living in ponds, to tolerating the freezing of much of the water in their bodies. This article will explore the strategies used by several amphibians to survive the winter, including strategies used by the boreal chorus frog, Columbia spotted frog, western toad, and western tiger salamander. Understanding the diverse ways that amphibians survive in their winter habitats helps scientists to recommend ways to protect those habitats, to ensure that amphibians have healthy places to live and reproduce.
The labor market in the digital era: What matters for the Gulf Cooperation Council countries?
Authors: Bousrih Jihen , Elhaj Manal , Hassan Fatma
Published: November 2022

Digital transformation affects all organizations, large and small. Waves of technological change are frequent and accelerating, requiring constant adaptation by companies and their employees. Artificial intelligence, automation, and digital tools are changing the traditional organizational structure and ways of working. After the COVID-19 pandemic, the labor market has to move toward an inclusive digital transformation that braces the business systems. This paper is an attempt to explore the effect of digitalization on employment in Gulf Cooperation Council (GCC) countries and compare them to some selected advanced countries. The methodology focuses on the second-generation unit root tests and the Auto Regressive Distributed Lagged model for the period 2000–2020. The findings show a negative and significant impact of ICT on employment in the industrial and services sectors for GCC countries with a moderate adjustment speed toward the long-run equilibrium. This result is explained by the shortage of skilled workers in GCC countries compared to advanced countries, where the findings show a positive and significant effect of ICT technologies on total employment, especially in the industrial sector. The adjustment speed toward the long run is significantly higher in advanced countries than in GCC countries.
Rapid variations of Si IV spectra in a flare observed by interface region imaging spectrograph at a sub-second cadence
Authors: Lörinčík Juraj , Polito Vanessa , De Pontieu Bart , Yu Sijie , Freij Nabil
Published: November 2022

We report on observations of highly-varying Si IV 1402.77 Å line profiles observed with the Interface Region Imaging Spectrograph (IRIS) during the M-class flare from 18 January 2022 at an unprecedented 0.8 s cadence. Moment analysis of this line observed in flare ribbon kernels showed that the intensity, Doppler velocity, and non-thermal broadening exhibited variations with periods below 10 s. These variations were found to be correlated with properties of the Gaussian fit to a well-resolved secondary component of the line redshifted by up to 70 km s−1, while the primary component was consistently observed near the rest wavelength of the line. A particularly high correlation was found between the non-thermal broadening of the line resulting from the moment analysis and the redshift of the secondary component. This means that the oscillatory enhancements in the line broadening were due to plasma flows (away from the observer) with varying properties. A simple de-projection of the Doppler velocities of the secondary component based on a three-dimensional reconstruction of flare loops rooted in the kernel suggests that the observed flows were caused by downflows and compatible with strong condensation flows recently predicted by numerical simulations. Furthermore, peaks of the intensity and the trends of Doppler velocity of the Gaussian fit to the secondary component (averaged in the ribbon) were found to correspond to one of the quasi-periodic pulsations (QPPs) detected during the event in the soft X-ray flux (as measured by the Geostationary Operational Environmental Satellite, GOES) and the microwave radio flux (as measured by the Expanded Owens Valley Solar Array, EOVSA). This result supports a scenario in which the QPPs were driven by repeated magnetic reconnection.
Isolation of BVDV-1a, 1m, and 1v strains from diarrheal calf in china and identification of its genome sequence and cattle virulence
Authors: Zhu Jie , Wang Chen , Zhang Lina , Zhu Tingting , Li Hanxiong , Wang Yunqiu , Xue Kaili , Qi Mingpu , Peng Qingjie , Chen Yingyu , Hu Changmin , Chen Xi , Chen Jianguo , Chen Huanchun , Guo Aizhen
Published: November 2022

Bovine viral diarrhea virus (BVDV) is an important livestock viral pathogen responsible for causing significant economic losses. The emerging and novel BVDV isolates are clinically and biologically important, as there are highly antigenic diverse and pathogenic differences among BVDV genotypes. However, no study has yet compared the virulence of predominant genotype isolates (BVDV-1a, 1b, and 1m) in China and the emerging genotype isolate BVDV-1v. The serological relationship among these genotypes has not yet been described. In this study, we isolated three BVDV isolates from calves with severe diarrhea, characterized as BVDV-1a, 1m, and novel 1v, based on multiple genomic regions [including 5-untranslated region (5′-UTR), Npro, and E2] and the phylogenetic analysis of nearly complete genomes. For the novel genotype, genetic variation analysis of the E2 protein of the BVDV-1v HB-03 strain indicates multiple amino acid mutation sites, including potential host cell-binding sites and neutralizing epitopes. Recombination analysis of the BVDV-1v HB-03 strain hinted at the possible occurrence of cross-genotypes (among 1m, 1o, and 1q) and cross-geographical region transmission events. To compare the pathogenic characters and virulence among these BVDV-1 genotypes, newborn calves uninfected with common pathogens were infected intranasally with BVDV isolates. The calves infected with the three genotype isolates show different symptom severities (diarrhea, fever, slowing weight gain, virus shedding, leukopenia, viremia, and immune-related tissue damage). In addition, these infected calves also showed bovine respiratory disease complexes (BRDCs), such as nasal discharge, coughing, abnormal breathing, and lung damage. Based on assessing different parameters, BVDV-1m HB-01 is identified as a highly virulent strain, and BVDV-1a HN-03 and BVDV-1v HB-03 are both identified as moderately virulent strains. Furthermore, the cross-neutralization test demonstrated the antigenic diversity among these Chinese genotypes (1a, 1m, and 1v). Our findings illustrated the genetic evolution characteristics of the emerging genotype and the pathogenic mechanism and antigenic diversity of different genotype strains, These findings also provided an excellent vaccine candidate strain and a suitable BVDV challenge strain for the comprehensive prevention and control of BVDV.