bluuebunny/crossref_metadata_2025 huggingface dataset:
STUDY OF ATMOSPHERIC PARTICLES OF THE NORTHERN PART OF ALTAI NATURE RESERVE
Authors: Дрозд Владимир , Drozd Vladimir , Калинкин Юрий , Kalinkin Yuriy , Серёдкин Иван , Seredkin Ivan , Чайка Владимир , Chayka Vladimir , Голохваст Кирилл , Golokhvast Kirill
Published: June 2018

The paper presents the results of laser granulometry study of atmospheric particles contained in the snow in the northern part of Altaiskiy State Nature Biosphere Reserve collected in winter 2016. The results of the study prove that the north of the Alay nature reserve is relatively safe ecologically. Harmful for living beings microparticels (of no more than 10 μm in size) were in the atmosphere in a limited number and were no more than 19.1%. At the same time the maximal concentration of fine substances was observed in places of a man living, which proves an anthropogenic cause of particles formation.
Russian language and culture of speech with the basics of style
Authors: Волосков Игорь , Voloskov Igor
Published: June 2018

In the tutorial, the basics of the training course " Russian language and culture of speech." Theoretical material is inextricably linked with practical training tasks, work with texts of different styles, literary editing of speech errors. The theoretical material is also accompanied by control questions, tasks, questions to offset.
Recursos cohesivos basados en elementos deícticos
Authors: Komorowska Agata
Published: June 2018

Cohesive Resources Based on Deictics ElementsThis article examines the role of deixis in cohesive devices used in written communication forms, focusing on the use of deictic elements for cohesion at various discourse levels, as well as the persistence of original meanings of such deictic elements in selected units, e.g. discourse markers and coreferential expressions.
léxico de origen hebreo en el judeoespañol contemporáneo
Authors: Pawłowska Marta
Published: June 2018

Hebrew-derived Lexicon in Contemporary Judeo-SpanishThe presence of a visible Hebrew component is one of the defining traits of the so-called “Jewish languages”. The aim of this paper is, therefore, to determine the scope of use of Hebrew-derived lexicon in contemporary Judeo-Spanish in its written variant. Our study will be based on the Sephardic press published mainly in Turkey and Israel.
Aspectos semántico-pragmáticos de los diminutivos en el español de la Ciudad de México
Authors: Słowik Magdalena
Published: June 2018

Pragmatic and Sociolinguistic Aspects of Diminutives in the Variety of Spanish Spoken in Mexico CityThe subject matter of the article is the analysis of suffixation of diminutives in the variety of Spanish spoken in Mexico City. The practical part is preceded by theoretical considerations. The aim of the study, based on an electronic corpus (Corpus Sociolingüístico de la Ciudad de México), is the identification of the functions of diminutives used in different situational contexts. The study focuses on statements made by Mexicans at the age of 20-34. Apart from linguistic factors, the sociolinguistic aspects such as sex and education level of the informants are analysed.
diccionarios de P. S. Pallas y Ph. A. Nemnich
Authors: Stala Ewa
Published: June 2018

The Dictionaries of P. S. Pallas and Ph. A. Nemnich. Findings and EnigmasThe main aim of the study is to present two lexicographic sources which contain Spanish lexical material and remain relatively unknown in the Spanish context which contain Spanish lexical material, namely Linguarum totius Orbis vocabularia comparativa, also called Dictionary of Catherine the Great (1787-1789), by Peter Simon Pallas, and Waaren-Lexicon in zwölf Sprachen (1797), by Philipp Andreas Nemnich. Both works were published in late 18th century, outside Spain, and their authors are two German scholars (a biologist and a lawyer). The present analysis uses the methodology corpus linguistics and it contributes new findings in the area of Spanish vocabulary: antedatings, new variants, new forms as well as the affiliation of the two dictionaries.
Situación laboral y cualificaciones profesionales de los profesores de español como lengua extranjera (ELE) en las escuelas secundarias de Polonia
Authors: Spychała-Wawrzyniak Małgorzata
Published: June 2018

Professional Status and Qualifications of Spanish Language Teachers in Secondary Schools in PolandThe goal of this paper is to present the professional status and qualifications of Spanish language teachers. We want to verify if the teachers employed in secondary schools in Poland possess adequate qualifications and competence, and whether they are professionally prepared for their task. Our preliminary assumption is that Spanish language teachers do not feel adequately prepared for school work. This may be cased by a shortage of experts in teaching Spanish in Polish secondary schools, and the current education standards for teachers, which practically ignore the specific issues of foreign language teaching. We also are interested in examining the reasons that made teachers choose this profession and their satisfaction with this choice. The methodology of the survey conducted is based on the analysis of online questionnaires conducted among secondary school teachers in Poland.
A Model of Two-Sided Costly Communication for Building New Product Category Demand
Authors: Lu Michelle Y. , Shin Jiwoong
Published: June 2018

When a firm introduces a radical innovation, consumers are unaware of the product’s uses and benefits. Moreover, consumers are unsure of whether they even need the product. In this situation, we consider the role of marketing communication as generating consumers’ need recognition and thus market demand for a novel product. In particular, we model marketing communication as a two-sided process that involves both firms’ and consumers’ costly efforts to transmit and assimilate a novel product concept. When the marketing communication takes on a two-sided process, we study a firm’s different information disclosure strategies for its radical innovation. We find that sharing innovation, instead of extracting a higher rent by keeping the idea secret, can be optimal. A firm may benefit from the presence of a competitor and its communication effort. The innovator can share its innovation so that competitors can also benefit, which encourages rivals to enter the market. The presence of such competition guarantees a higher surplus for consumers, which can induce greater consumer effort in a two-sided communication process. Moreover, the increased consumer effort, in turn, prompts complementarity in the communication process and lessens the potential free-riding effect in communication between firms. Additionally, it encourages the rival firm to exert more effort, especially when the role of consumers becomes more important. Sharing innovation with a rival serves as a mechanism to induce more efforts in a two-sided communication process.

The online appendix is available at https://doi.org/10.1287/mksc.2017.1071 .
Identifying and addressing barriers to men seeking help for depression
Authors: Ellis Kelly-Anne
Published: June 2018

Men are more reluctant than women to seek help for mood and mental health disorders. A literature search was carried out to identify barriers to help-seeking behaviour in men, the strategies they use that delay looking for assistance and the impact professionals' perceptions can have when men do seek assistance. Gender ideology and the associated beliefs men hold is the dominant barrier influencing help-seeking behaviour. Men often adopt an approach that delays the help-seeking process. Understanding this can provide an insight into the strategies often adopted by men in preference to seeking help from professionals. There is also unfortunately prevailing negativity in the perceptions of health care professionals that may have an impact on men accessing help. The article expands on these points and discusses how to apply current and evidence-based knowledge into practice.
Small Animal Review
Authors: Tennant Bryn
Published: June 2018

Introduction:

Renal cytology is an underused but valuable tool in the diagnosis of renal disease, particularly when combined with ultrasonography. Adequate samples that are clinically useful are obtainable in 73% of cases. Imaging potentially aids in the differentiation of neoplastic from non-neoplastic lesions.
Superficial bacterial folliculitis
Authors: Patel Anita
Published: June 2018

Superficial bacterial folliculitis is a bacterial infection that involves the upper portion of the hair follicle. The most common cause of superficial bacterial folliculitis is Staphylococcus pseudintermedius, and it is almost always secondary to an underlying disease. The clinical signs vary from scaling, raised tufts of hairs and alopecia, which gives some affected animals a moth-eaten appearance, to lichenification and hyperpigmentation; the distribution of the lesions usually takes that of the underlying condition. Pruritus is variable. The diagnosis is based on the history, clinical signs, and cytological and/or histological findings. Whether topical and/or systemic treatment is advocated depends on the history, clinical signs, laboratory findings and the extent of the disease. This articlr discusses the common pathogens, predisposing factors, clinical signs, diagnosis and treatment of superficial bacterial folliculitis.
Drug interactions amongst companion animal parasiticides
Authors: Wright Ian , Elsheikha Hany
Published: June 2018

The global burden of ectoparasitic infestations is exacerbated by the lack of licensed vaccines, making safe and effective parasiticide drugs vital to their prevention and treatment. The last two decades in the companion animal parasiticides market has brought a welcome surge in the number of new antiparasitic agents. However, this requires veterinary prescribers to be much more knowledgeable about drug mode of action, indications, adverse reactions, and the potential for drug–drug interactions. Most antiparasitic drugs have an acceptable safety margin, however some are associated with clinically significant side effects or drug–drug interactions. The risk for these side effects can be increased when drugs are used in combination, and by concurrent medications prescribed for preexisting conditions. This article describes the risk of acute adverse reactions associated with treatment with antiparasitic drugs and highlights the current safety warnings regarding concurrent use of some drugs.
Hay for a healthy rabbit: the importance of appropriate feed
Authors: Bourne Debra
Published: June 2018

Rabbits are herbivores with teeth and a gastrointestinal system adapted for a high-fibre, low-nutrient diet. Providing an appropriate diet, based on grass or grass hay supplemented with vegetables and only small amounts of concentrates, is important for tooth health, gut function and maintenance of a healthy weight. Water is also essential, and most rabbits prefer a bowl to a sipper bottle. Rabbits that fail to ingest their caecotrophs and those with diarrhoea (which is rarer) may become soiled and prone to flystrike. Obesity resulting from excess concentrate feed can lead to health problems including soiling and arthritis, and obese rabbits are more likely to develop life-threatening hepatic lipidosis if they stop eating for any reason. Stress minimisation is important in hospitalised rabbits to avoid anorexia, which has potentially life-threatening consequences.
Socially-inclusive dentistry
Authors: Doughty Janine , Parker Deborah
Published: June 2018

Janine Doughty and Deborah Parker discuss the many issues of homelessness within the context of dentistry and reveal how dental nurses are leading the way
Equality in dental care
Authors: Haslam Sarah
Published: June 2018

Sarah Haslam discusses a project that aims to deliver good mouth care to those patients with learning difficulties
The salesmanship of dental care
Authors: Middleton Anna
Published: June 2018

The art of establishing long-lasting good oral hygiene habits involves effective instructions and good communication. But ethical sales also now play a big part in achieving patient behaviour change. ‘London Hygienist’ and Philips key opinion leader, Anna Middleton, explains
‘A real buzz’
Authors: Pomphrett Melanie
Published: June 2018

Melanie Pomphrett reveals what it takes to inspire others – and why she thinks oral health education has a healthy future
Are you our next award winners?
Authors: Kear Joanne
Published: June 2018

Could you be the schülke Infection Prevention & Control Team of 2018? We hear from Joanne Kear, practice manager of last year's winners, Milne, Spencer & Harris Dental Practice
‘Your teeth you are in control’
Authors: Marshman Zoe , Noble Fiona , Rodd Helen
Published: June 2018

The use of cognitive behavioural therapy in reducing dental anxiety for paediatric patients
The ‘inbetweeners’
Authors: Sharma Priya
Published: June 2018

Priya Sharma considers the evidence for the use of floss and interdental brushes in oral health regimes
Periodontal disease and systemic health – a summary
Authors: Bissett Gaby
Published: June 2018

The oral-systemic connections are now widely accepted – the strength of the links, however, continues to challenge researchers looking for answers. Gaby Bissett considers the evidence so far
Biofilm formation
Authors: Bacon Peter
Published: June 2018

Peter Bacon discusses the problem of biofilm formation and the best management strategies to control its growth in dental unit waterlines
Have you found the ideal match?
Authors: Hameed Natasha
Published: June 2018

Recruitment consultant Natasha Hameed explains the nuances and skills in nailing that perfect job
Total hip arthroplasty in patients affected by poliomyelitis
Authors: DeDeugd C. M. , Perry K. I. , Trousdale W. H. , Taunton M. J. , Lewallen D. G. , Abdel M. P.
Published: June 2018

Aims

The aims of this study were to determine the clinical and radiographic outcomes, implant survivorship, and complications of patients with a history of poliomyelitis undergoing total hip arthroplasty (THA) in affected limbs and unaffected limbs of this same population.

Patients and Methods

A retrospective review identified 51 patients (27 male and 24 female, 59 hips) with a mean age of 66 years (38 to 88) and with the history of poliomyelitis who underwent THA for degenerative arthritis between 1970 and 2012. Immigrant status, clinical outcomes, radiographic results, implant survival, and complications were recorded.

Results

In all, 32 THAs (63%) were performed on an affected limb, while 27 (37%) were performed on an unaffected limb. The overall ten-year survivorship free from aseptic loosening, any revision, or any reoperation were 91% (95% CI 0.76 to 0.99), 91% (95% CI 0.64 to 0.97) and 87% (95% CI 0.61 to 0.95), respectively. There were no revisions for prosthetic joint infection. There were no significant differences in any of the above parameters if THA was on the affected or unaffected control limbs.

Conclusion

Patients with a history of poliomyelitis who undergo THA on the affected or unaffected limbs have similar results with overall survivorship and complication rates to those reported results in patients undergoing THA for osteoarthritis. At long-term follow-up, previous clinical concerns about increased hip instability due to post-polio abductor weakness were not observed. Cite this article: Bone Joint J 2018;100-B:733–9.
Switching the behaviour of consumers to circular products and services with particular reference to the appeal of green batteries: An econometric analysis of evidence from Thailand
Authors: Dokmai Bancha
Published: June 2018

Used and discarded primary batteries are a major source of toxic pollution. The substitution of green primary batteries for conventional non-green batteries is however contingent on consumers’ willingness to pay premium prices for green primary batteries. The aim of this article is to explore evidence as to whether the environmental concern of individuals can prompt them to pay premium prices for green primary batteries. An econometric model is used to investigate the determinants of consumers’ purchasing behaviour and their willingness to pay premium prices for green batteries. Data for the study were obtained through a survey of Thai consumers in July 2016, which elicited 213 responses. An Analysis of the survey data shows significant evidence of environmental concern among Thai consumers as a factor that bears on the willingness to pay premium prices for green battery products and services. Gender, age and product lifespan are also shown to influence preference for green battery products and services. Further findings include that Thai consumers would pay a premium of 29 per cent over the price of non-green conventional battery price to enhance their concern for the environment, but that they would make no distinction between eco-labelled green primary batteries the production and use of which corresponds the ‘cradle-to-grave’ business model; and green battery product services, which relate to the ‘closed loop’, circular economy business model.
Exploring factors influencing technology transfer capability: Constructing a model through grounded theory
Authors: Huynh Tai Thao
Published: June 2018

The purpose of this qualitative research is to explore a conceptualization of factors that influence technology transfer capability. It identifies what and how factors perceived by expert participants impact technology transfer. Data from in-depth semi-structured interviews with twenty participants, who are experts in the field of technology management from top food enterprises, were analysed using grounded theory methodology to categorize concepts and conceptualize a provisional model. NVivo software application was used for qualitative data analysis. The study results identify organizational, departmental and environmental factors that impact technology transfer capability. Seven main themes emerged relating to: (1) new technology identification, acquisition and implementation ability; (2) research and development (R&D) ability; and (3) external environment. The data also clearly illustrate how these factors work in the food industry context and provide a foundation for developing a theoretical framework. The article provides implications for the development of a more complete model of determinants of technology transfer capability for firm owners, policy-makers and technology managers to develop more sustainable strategies to boost firms’ technology transfer and enhance competitive advantage. This article fulfills an identified need to study technology transfer capability and fills a literature gap in technology management by a qualitative study of industry experts.
Implementation of cleaner production along with quality management tools
Authors: Cotrim Syntia Lemos , Filho Dante Alves Medeiros , Leal Gislaine Camila Lapasini , Galdamez Edwin Vladimir Cardoza
Published: June 2018

Industries use management models and tools to meet environmental standards, while maintaining economic growth at a sustainable level. There is a growing body of knowledge about the implementation of cleaner production methods; however, questions as to which tools to use in the collection and analysis of data about the production process, or how to prioritize actions for improvement of the production process, have not yet been adequately addressed. This article evaluates models in order to obtain a method that integrates the concept of cleaner production integrated method (CPIM) with quality management tools and techniques. Cleaner production methods alone are very vague and the application of its stages is far from clear. So the use of quality management tools would give the much required support for the implementation of cleaner production programmes. To evaluate this model, a case study is presented in an industry in the food sector. This research has enabled the analysis of the applicability of the method and its impact in reducing waste generation and consumption of natural resources. As a result, a 19 per cent reduction was obtained in total waste generation and 35 per cent reduction in waste generation in the main sector where the method was applied.
MIGRACIÓN Y VIOLENCIA CONTRA LA MUJER MIGRANTE Y REFUGIADAS
Authors: Morell Ana , Salles Denise Mercedes Nuñez Nascimento Lopes , Santoro Antonio Eduardo Ramires
Published: June 2018

El régimen que proscribe la violencia doméstica y familiar en Brasil está establecido en la Ley número 11.340, que garantiza a toda mujer el disfrute de los derechos fundamentales inherentes a la persona humana, independientemente de su clase, raza, etnia, orientación sexual, renta, nivel cultural y educacional, edad y religión. Llamativamente, estos términos calificativos no son definidos por la norma ni la misma hace alusión a los grupos especialmente vulnerables a esta violencia, olvidando así a uno de los grupos más susceptibles de ser victimizados: mujeres migrantes y refugiadas. En este artículo se intenta, teniendo presente el objeto de la norma, conferir al derecho a disfrutar de una vida libre de violencia un sentido y alcance concreto que se inserta coherentemente con su formulación positiva en Derecho internacional.
Education for Sustainability beyond the Classroom: Companies Born in University Incubators
Authors: Brito Margarete Dias , Brunstein Janette , Amaro Rubens Araújo
Published: June 2018

This study attempts to fill a gap in the literature, which focuses its efforts on the analysis of the education for sustainability in formal business courses and not on the incubation spaces at universities. The intention was to understand the sense of developing a business which incorporates sustainability principles, and debating the role of the university in fostering socio-environmental practices among the new generation of entrepreneurs, with a focus on Brazilian experiences. This qualitative research investigated companies in incubator programs at four Brazilian university business incubators, regarding: the attention to the way the business project is selected in the incubators; the sources and nature of the incubators’ socio-environmental concerns; the meaning of sustainability for these entrepreneurs; the way they put these principles into action in their business plans; the difficulties and challenges they face in meeting socio-environmental goals in their companies, and, finally, the inductor incubator’s role in fostering sustainable businesses. The results are alarming, since investment in education for sustainability seemed to be almost inexistent, which has consequences for generations of born and raised companies in incubators at universities. The findings also offer a route for debating and analyzing relevant aspects of education for sustainability in this academic environment.
ASPIRASI KARIR, REGULASI DIRI, DAN SELF-PERCEIVED EMPLOYABILITY PADA MAHASISWA
Authors: Sawitri Dian Ratna , Dewi Kartika Sari
Published: June 2018

Self-perceived employability is individual’s perceived ability to get sustainable employment appropriate to one’s qualification level. Previous researches demonstrated the importance of self-regulation in shaping self-perceived employability in emerging adulthood, when career aspirations have a significant role in career-related decision-making process. However, the relationships between career aspirations, self-regulation, and self-perceived employability among university students were rarely known. This study examined a theoretical model, whether self-regulation served as a partial mediator between career aspirations and self-perceived employability. Using a convenience sampling, we involved 600 university students who were at their second, fourth, sixth, eighth, and tenth semester (68% female, M age = 19.97 years; SD = 5.57) from a university in Semarang. Structural equation modeling demonstrated that career aspirations were associated with self-perceived employability directly and indirectly via self-regulation. It means, the higher students career aspirations, the better their self-regulation and self-perceived employability. Self-regulation also leads to higher self-perceived employability. We interpreted the findings of this study form developmental and goal-setting perspective. To promote self-perceived employability, students are recommended to boost their career aspirations and develop a good self-regulation skill.
MENGATUR DESA WISATA: WAWASAN PERAN LOCAL CHAMPION DALAM PENGEMBANGAN PARIWISATA BERBASIS KOMUNITAS
Authors: Hanajayani Gangsar , Sariffuddin Sariffuddin
Published: June 2018

Kaligono Tourism Village (Dewi Kano) was one of ten national tourism village according to the Ministry of Tourism and Creative Economy in 2014. Dewi Kano had been successfully implementing the PNPM Mandiri Pariwisata. The main concept of Kaligono tourism village development is communities empowerment in the planning process, implementation, and utilization of resources. The role of the community successfully influence the development of Kaligono tourism village. This achievement inflicted the question researcher "what the role of the community and how the management system in Kaligono Tourism Village?". This reseach aimed to identify the role of communities in the management of Kaligono Tourism Village (Dewi Kano). The research used descriptive qualitative with snowballing method. The results of this research shows that the villagers Kaligono implemented community development through the tourism sector. Development of Dewi Kano due to the initiative of the community, both individuals and groups. According stakeholder mapping, Pokdarwis is a player who has interest and major influence on the development of Dewi Kano. Communities act as planners, implementers, and beneficiaries of a tourist village in collaboration with external as partners and supporters, and also the government as the supervisor and advisor. Consistency which Pokdarwis did to manage Kaligono tourism village is the key of existence of tourism village.
On the well-posedness of a multiscale mathematical model for Lithium-ion batteries
Authors: Díaz J. Ildefonso , Gómez-Castro David , Ramos Angel M.
Published: June 2018

We consider the mathematical treatment of a system of nonlinear partial differential equations based on a model, proposed in 1972 by J. Newman, in which the coupling between the Lithium concentration, the phase potentials and temperature in the electrodes and the electrolyte of a Lithium battery cell is considered. After introducing some functional spaces well-adapted to our framework, we obtain some rigorous results showing the well-posedness of the system, first for some short time and then, by considering some hypothesis on the nonlinearities, globally in time. As far as we know, this is the first result in the literature proving existence in time of the full Newman model, which follows previous results by the third author in 2016 regarding a simplified case.
Natural locations and the distinction between ‘what’ and ‘where’ concepts: Evidence from differential locative marking in Makalero
Authors: Huber Juliette
Published: June 2018

Differential locative marking is found in languages all over the world. Toponyms, in particular, are well known to often require less locative marking than other types of nouns, and it has been suggested that they express ‘where’ concepts. This paper presents a case study of differential locative marking in Makalero, a Papuan language of East Timor, where nouns fall into three categories: those which need no overt locative marking, i.e., can be zero-marked; those which are used with a semantically general locative verb; and those which can only be used with semantically specific locative verbs. Zero-marking of spatial relations occurs only in a specific construction where the nouns in question are used predicatively, suggesting that the syntactic equivalent of the ‘where’ category is a relational expression, not a noun. There is furthermore a certain degree of flexibility in Makalero locative constructions, and alternative expressions result in predictable semantic differences. These differences show that the lack of perceptual boundaries and of an internal structure are important parameters that distinguish the referents of so-called natural location nouns from nouns which denote ‘what’ concepts. More comparative case studies are needed to enrich our understanding of these notions and the properties characterizing them.
(K)eine Frage der Religion?
Authors: Leszczensky Lars
Published: June 2018

Beeinflusst Religion die soziale Integration von Migranten? Obwohl diese Frage wichtiger denn je ist, mangelt es an belastbaren Befunden. Im vorliegenden Beitrag argumentiere ich, dass Religion die Entwicklung enger, freundschaftlicher Kontakte zu Deutschen, nicht jedoch die allgemeine Kontakthäufigkeit beeinflusst. Mit Längsschnittdaten des SCIP-Projekts zeige ich, dass die Entwicklung allgemeiner interethnischer Kontakte für christliche und muslimische Neuzuwanderer parallel verläuft. Im Gegensatz dazu nehmen enge Kontakte mit steigender Aufenthaltsdauer nur zwischen christlichen Zuwanderern und Deutschen zu, wohingegen sie für Muslime auf geringem Niveau stagnieren. In Folge dieser unterschiedlichen Verläufe bestehen nach drei Jahren Aufenthalt trotz anfänglich ähnlich gering ausgeprägtem engem Kontakt mit Deutschen substanzielle Unterschiede zwischen christlichen und muslimischen Neuzuwanderern. Diese Unterschiede sind nicht auf individuelle Religiosität, Sprachfähigkeiten und Erwerbstätigkeit zurückzuführen.
Protease-mediated Inflammation: An In Vitro Human Keratinocyte-based Screening Tool for Anti-inflammatory Drug Nanocarrier Systems
Authors: Frombach Janna , Lohan Silke B. , Lemm Davina , Gruner Paul , Hasler Julia , Ahlberg Sebastian , Blume-Peytavi Ulrike , Unbehauen Michael , Haag Rainer , Meinke Martina C. , Vogt Annika
Published: June 2018

Background:

Refined encapsulation approaches in dermatotherapy gain increased interest. There is need of reproducible in vitro systems representing disease features to screen drug delivery systems for preclinical assessment. Inflammatory human skin diseases are commonly accompanied by abnormal epidermal differentiation and barrier impairment. Serine proteases (SPs) and their inhibitors play a critical role in such dysfunctional differentiation. SPs also initiate cellular pathways via activation of protease-activated receptors, which contribute to inflammation. Thus, function and activity of SPs should be considered for the design of new therapies of such disorders.

Objectives:

Herein, we established a novel simplified cell culture model, based on SP-mediated inflammation suitable to assess nanocarriers loaded with anti-inflammatory drugs.

Methods:

SP-mediated inflammation and the regulatory effect of free or encapsulated dexamethasone were determined by measuring interleukin-6 and interleukin-8 in culture medium of HaCaT (human adult low calcium temperature)-keratinocytes. Additionally, radical formation was analyzed by electron paramagnetic resonance spectroscopy. Cellular uptake of core-multishell nanocarriers was investigated by fluorescence microscopy. Cytotoxicity of all additives was determined by a viability assay.

Results:

SP-Stimulation of keratinocytes resulted in increased radical production and release of inflammatory cytokines without affecting cell viability. Induced inflammation was successfully downregulated by addition of free or encapsulated dexamethasone.

Conclusion:

SP-addition can be used as inflammatory stimulus in cell culture to mimic effects of aberrant enzymatic activities found in skin of atopic dermatitis patients. The set-up is appropriate as a preliminary test to examine the effectiveness of new molecules or delivery-systems to counteract serine protease-mediated inflammatory processes prior to skin studies.
El tratamiento periodístico del partido político Podemos en El País y Público: un análisis desde la teoría del framing
Authors: Peris Vidal Manuel
Published: June 2018

La irrupción de Podemos en el panorama político español en el año 2014 supuso una gran revolución en el sistema tradicional de partidos, puesto que esta formación recogió gran parte del voto de la ciudadanía descontenta con los recortes presupuestarios y con la extensión de la corrupción política durante la última década. Debido a que Podemos se ha convertido en una amenaza para PP y PSOE, las críticas de algunos medios de comunicación hacia este partido han ido en aumento. Sin embargo, también se ha producido el apoyo incondicional a dicho partido por parte de otros medios. Como consecuencia, hemos creído necesario llevar a cabo, desde la teoría del framing,  y a través del análisis de contenido, un examen del enfoque dado por los diarios El País y Público a las noticias sobre Podemos en noviembre de 2016.  Nos ha parecido relevante el análisis del tratamiento periodístico de ciertos aspectos que caracterizan el discurso del secretario general de la formación, Pablo Iglesias, como la identificación de Podemos con el pueblo o la descalificación sistemática de todo aquel que se muestre crítico con su partido.
Physiological Responses to Swimming Repetitive “Ice Miles”
Authors: Knechtle Beat , Stjepanovic Mirko , Knechtle Celina , Rosemann Thomas , Sousa Caio V. , Nikolaidis Pantelis T.
Published: June 2018

Knechtle, B, Stjepanovic, M, Knechtle, C, Rosemann, T, Sousa, CV, and Nikolaidis, PT. Physiological responses to swimming repetitive “Ice Miles.” J Strength Cond Res 35(2): 487–494, 2021—“Ice Mile” swimming (i.e., 1,608 m in water of below 5° C) is becoming increasingly popular. Since the foundation of the International Ice Swimming Association (IISA) in 2009, official races are held as World Cup Races and World Championships. Ice swimming was a demonstration sport at the 2014 Winter Olympics in Sochi, Russia. This case study aimed to identify core body temperature and selected hematological and biochemical parameters before and after repeated “Ice Miles.” An experienced ice swimmer completed 6 consecutive Ice Miles within 2 days. Three Ice Miles adhered to the strict criteria for the definition of Ice Miles, whereas the other 3 were very close (i.e., 5.2, 6.1, and 6.6° C) to the temperature limit. Swimming times, changes in core body temperatures, and selected urinary and hematological parameters were recorded. The athlete showed after each Ice Mile a metabolic acidosis (i.e., an increase in lactate and TCO2; a decrease in base excess and HCO3
−) and an increase in blood glucose, cortisol, and creatine kinase concentration. The decrease in pH correlated significantly and negatively with the increase in cortisol level, indicating that this intense exercise causes a metabolic stress. The change in core body temperature between start and finish was negatively associated with metabolic acidosis. The increase in creatine kinase suggests skeletal muscle damages due to shivering after an Ice Mile. For athletes and coaches, swimming in cold water during Ice Miles leads to a metabolic acidosis, which the swimmer tries to compensate with a respiratory response. Considering the increasing popularity of ice swimming, the findings have practical value for swimmers and practitioners (e.g., coaches, exercise physiologists, and physicians) working with them because our results provide a detailed description of acute physiological responses to repeated swimming in cold conditions. These findings are of importance for athletes and coaches for National Championships and World Championships in Ice Swimming following the IISA rules.
Depression in Adults with Congenital Heart Disease: Prevalence, Prognosis, and Intervention
Authors: Ko Jong Mi , Cedars Ari M.
Published: June 2018

Data on the prevalence of depression in adult congenital heart disease (ACHD) patients differ widely. We aim to summarize the best available information on the prevalence of depression, its prognostic impact, and psychiatric interventions for depressed ACHD patients. We reviewed references in relevant publications up to October 17, 2017. For homogeneity of data, studies in which depression was independently assessed in patients aged 18 years or older or with a mean/median age older than 18 years were included. Retrospective and postoperative evaluation studies were excluded. Twenty publications met these criteria. Study samples included ACHD patients followed up at ACHD-specialized hospitals in 13 countries. The prevalence of depression differed widely, ranging from 6 to 69%. Depression has been shown to be an independent predictor of adverse clinical outcomes. It is also frequently associated with other prognostic variables (i.e., poor functional class, unfavorable perceived health status, and low quality of life). Currently, no randomized clinical trials on psychiatric interventions in ACHD are available. In summary, depression is highly prevalent in ACHD patients, yet it is often unrecognized and untreated. The adverse prognostic impact of depression calls for specialized psychiatric interventions, for which more research is needed in the ACHD patient population.
MECHANISMS IN ENDOCRINOLOGY: Hypophysitis: diagnosis and treatment
Authors: Joshi Mamta N , Whitelaw Benjamin C , Carroll Paul V
Published: June 2018

Hypophysitis is a rare condition characterised by inflammation of the pituitary gland, usually resulting in hypopituitarism and pituitary enlargement. Pituitary inflammation can occur as a primary hypophysitis (most commonly lymphocytic, granulomatous or xanthomatous disease) or as secondary hypophysitis (as a result of systemic diseases, immunotherapy or alternative sella-based pathologies). Hypophysitis can be classified using anatomical, histopathological and aetiological criteria. Non-invasive diagnosis of hypophysitis remains elusive, and the use of currently available serum anti-pituitary antibodies are limited by low sensitivity and specificity. Newer serum markers such as anti-rabphilin 3A are yet to show consistent diagnostic value and are not yet commercially available. Traditionally considered a very rare condition, the recent recognition of IgG4-related disease and hypophysitis as a consequence of use of immune modulatory therapy has resulted in increased understanding of the pathophysiology of hypophysitis. Modern imaging techniques, histological classification and immune profiling are improving the accuracy of the diagnosis of the patient with hypophysitis. The objective of this review is to bring readers up-to-date with current understanding of conditions presenting as hypophysitis, focussing on recent advances and areas for future development. We describe the presenting features, investigation and diagnostic approach of the patient with likely hypophysitis, including existing conventional techniques and those in the research/development arena. Hypophysitis usually results in acute and persistent pituitary hormone deficiency requiring long-term replacement. Management of hypophysitis includes control of the inflammatory pituitary mass using a variety of treatment strategies including surgery and medical therapy. Glucocorticoids remain the mainstay of medical treatment but other immunosuppressive agents (e.g. azathioprine, rituximab) show benefit in some cases, but there is a need for controlled studies to inform practice.
SPEN protein expression and interactions with chromatin in mouse testicular cells
Authors: Korfanty Joanna , Stokowy Tomasz , Chadalski Marek , Toma-Jonik Agnieszka , Vydra Natalia , Widłak Piotr , Wojtaś Bartosz , Gielniewski Bartłomiej , Widlak Wieslawa
Published: June 2018

SPEN (spen family transcription repressor) is a nucleic acid-binding protein putatively involved in repression of gene expression. We hypothesized that SPEN could be involved in general downregulation of the transcription during the heat shock response in mouse spermatogenic cells through its interactions with chromatin. We documented predominant nuclear localization of the SPEN protein in spermatocytes and round spermatids, which was retained after heat shock. Moreover, the protein was excluded from the highly condensed chromatin. Chromatin immunoprecipitation experiments clearly indicated interactions of SPEN with chromatinin vivo. However, ChIP-Seq analyses did not reveal any strong specific peaks both in untreated and heat shocked cells, which might suggest dispersed localization of SPEN and/or its indirect binding to DNA. Usingin situproximity ligation assay we found closein vivoassociations of SPEN with MTA1 (metastasis-associated 1), a member of the nucleosome remodeling complex with histone deacetylase activity, which might contribute to interactions of SPEN with chromatin.
EU-Beihilfenrecht und sog. Defizitausgleiche zugunsten öffentlicher Krankenhäuser
Authors: Cremer Wolfram
Published: June 2018

Der in der EU und nicht zuletzt in Deutschland weit verbreitete und unter Verwendung öffentlicher Mittel geleistete Ausgleich von Defiziten, welche in öffentlichen Krankenhäusern auflaufen (sog. Defizitausgleich) ist seit ca. 15 Jahren Gegenstand einer EU-beihilfenrechtlichen Kontroverse. Gefordert wird im Anschluss an das unionsrechtliche Beihilfenverbot des Art. 107 Abs. 1 AEUV teils nicht weniger als die Schließung sämtlicher (strukturell resp. fortwährend) defizitärer öffentlicher Krankenhäuser. Freilich fehlten lange Zeit thematisch einschlägige gerichtliche Stellungnahmen. Dies hat sich in Gestalt von Entscheidungen des EuG aus dem Jahre 2012 und des BGH (und des OLG Stuttgart) aus dem Jahre 2016 geändert. Freilich sind die Judikate nicht leicht zu dechiffrieren. Vor diesem Hintergrund wagt der vorliegende Beitrag einen systematisch angelegten Entschlüsselungsversuch und entwickelt zugleich − unter Rückbesinnung auf beihilfenrechtliche Grundlagen – rechtsdogmatisch begründete Alternativangebote. In diesem Zusammenhang wird auch herausgearbeitet, dass ein (partieller) Abschied von der Altmark-Rechtsprechung des EuGH zu Dienstleistungen von allgemeinem wirtschaftlichem Interesse beihilfenrechtlich angezeigt und in den Judikaten von EuG und BGH stillschweigend mitgedacht ist.
5-ASA Induces Mild Acute Pancreatitis. Case Report and Review of the Literature
Authors: Meczker Ágnes , Mikó Alexandra , Hegyi Péter
Published: June 2018

5-aminosalicylic acid has been reported to be able of inducing acute pancreatitis as an adverse reaction. However, in most case reports, rechallenge of the drug is missing; therefore, evidence is still needed to confirm its role in the clinical course of acute pancreatitis and its influence on the outcome. Here, we report a case of recurrent acute pancreatitis secondary to 5-aminosalicylic acid, with positive unintentional rechallenge. A systematic search of the literature was performed and 42 cases from 35 articles were summarized concerning the clinical course of 5-aminosalicylic acid induced acute pancreatitis.
Liver stiffness better predicts portal hypertension after HCV eradication
Authors: Radu Corina , Stancu Oana , Sav Roxana , Bugariu Anca , Suciu Alina , Grigoras Crina , Procopet Bogdan , Stefanescu Horia , Sparchez Zeno
Published: June 2018

.
Neonatal Circumcision and Urinary Tract Infections in Infants With Hydronephrosis
Authors: Ellison Jonathan S. , Dy Geolani W. , Fu Benjamin C. , Holt Sarah K. , Gore John L. , Merguerian Paul A.
Published: June 2018

BACKGROUND:

Boys with urinary tract abnormalities may derive a greater benefit from newborn circumcision for prevention of urinary tract infection (UTI) than the general population. However, the effect of newborn circumcision on UTI is not well characterized across the etiological spectrum of hydronephrosis. We hypothesized that boys with an early diagnosis of hydronephrosis who undergo newborn circumcision will have reduced rates of UTI.

METHODS:

The MarketScan data set, an employer-based claims database, was used to identify boys with hydronephrosis or hydronephrosis-related diagnoses within the first 30 days of life. The primary outcome was the rate of UTIs within the first year of life, comparing circumcised boys with uncircumcised boys and adjusting for region, insurance type, year of birth, and infant comorbidity.

RESULTS:

A total of 5561 boys met inclusion criteria, including 2386 (42.9%) undergoing newborn circumcision and 3175 (57.1%) uncircumcised boys. On multivariate analysis, circumcision was associated with a decreased risk of UTI in both boys with hydronephrosis and healthy cohorts: odds ratio (OR) 0.36 (95% confidence interval [CI] 0.29–0.44) and OR 0.32 (95% CI 0.21–0.48), respectively. To prevent 1 UTI, 10 patients with hydronephrosis would have to undergo circumcision compared with 83 healthy boys. Among specific hydronephrosis diagnoses, circumcision was associated with a reduced risk of UTI for those with isolated hydronephrosis (OR 0.35 [95% CI 0.26–0.46]), vesicoureteral reflux (OR 0.35 [95% CI 0.23–0.54]), and ureteropelvic junction obstruction (OR 0.35 [95% CI 0.20–0.61]).

CONCLUSIONS:

Newborn circumcision is associated with a significantly lower rate of UTI among infant boys with hydronephrosis.
Maintained load-test results for continuous flight auger piles in south-east England Chalk
Authors: Ball Jon , Oram Chris , Hull John , Hill Julia
Published: June 2018

This paper presents a case study of the results from Roger Bullivant Ltd's testing database from the last 4 years, consisting of eight working load tests and one preliminary test spread across five sites in south-east England. The paper covers the geology of each site and the design of the piles, which was carried out using current industry design practice. The results were analysed to predict the ultimate shaft friction of each pile. As the test results demonstrated that the piles behaved satisfactorily at working load, it is argued that the piles could be seen to be uneconomical. When piles in Chalk are tested, it is common that they rarely deflect to a point where any noticeable failure is deemed to occur. Through a comparison of available published data together with this new data set, a more efficient design is proposed for piles in Chalk with a higher limiting shaft friction value.
Hilbert curve fractal antenna for detection and on-line monitoring of partial discharges in power transformers
Authors: Sikorski W. , Szymczak C. , Siodła K. , Polak F.
Published: June 2018

This article describes the design of UHF Hilbert curve fractal antenna (HCFA) specially adapted for the partial discharge monitoring system. The authors present the mathematical apparatus for calculating resonant frequencies of Hilbert fractal antenna and
results of a computer simulation of the developed prototype. In the design process, the antenna’s working environment (mineral
oil) and the mechanical construction of the transformer inspection window were taken into consideration as well. The article also
shows the results of laboratory tests carried out in the transformer tank model with different type of partial discharge sources.
Both simulations and partial discharge measurements showed that the HCFA, due to such properties as: multi-resonance, small
size, low fabrication cost and high sensitivity, is an interesting alternative to other UHF probes installed in transformer inspection
window
The use of Plackett-Burman plans and the analysis of expert opinions, in order to assess the significance of controllable parameters of the plasma cutting process
Authors: Feldshtein E. , Patalas-Maliszewska J. , Kłos S. , Kałasznikow A. , Andrzejewski K.
Published: June 2018

This article evaluates the significance of controllable parameters in the plasma cutting process, using the Plackett-Burman Method and the Analysis of Expert Opinions Method. The plasma cutting process was tested using a WPA-6000 Compakt plasma cutter,
on non-alloy steel, of the S235JR EN 10025-2:2007 grade, with a carbon equivalent of 0.35%. The effect of the thickness of the
sheet, the current flow rate, the cutting speed, the gas pressure during cutting, the height of the torch during cutting, the pierce
delay time and the initial pierce height, were analysed. The research revealed the influence of the controllable parameters tested,
in the plasma cutting process, on selected output parameters, surface cut drag lines, the width of the kerf at the inlet and outlet,
and the value of the perpendicularity of the kerf on the surface of the base. The greatest influences were recorded for intensity of
cutting current, cutting speed and gas pressure during cutting. The results obtained were confirmed by the results of the analysis
of expert opinions