bluuebunny/crossref_metadata_2025 huggingface dataset:
The Influence of Children’s Psychological Language Development Based on Computer Digital Statistics Technology
Authors: Zhu Han , Yang Yi
Published: June 2022

Children’s psychological language development cannot be explained by the mechanism of adults learning a second language, and there are great differences between them. Children’s language acquisition ability is congenital. They can obtain language information with the help of sensory organs and learn language features through brain black box processing. Therefore, studying the influence of children’s psychological language development is helpful to solve the problem of human language learning and provide a reliable research basis for language education. An important research method of psycholinguistics is behavioral experiment, which can provide detailed and real research materials and data on children’s language learning process, but it cannot reflect children’s psychological process. In this paper, the computer digital statistical technology model is introduced into the research on the impact of children’s psychological language development, combined with the dual network model of language model to simulate the psychological mechanism of children’s language acquisition process. The simulation results of the model show that the acquisition of phoneme category has an important impact on children’s language development. Compared with before learning, after children complete learning, the clustering and compactness of language consonant and vowel phoneme range are improved, which promotes the learning of language features.
On an Explicit Characterization of Spherical Curves in Dual Lorentzian 3-SpaceD13
Authors: Abdel-Baky Rashad A. , Mofarreh Fatemah
Published: June 2022

In this study, we developed a mathematical framework for studying spherical and null curves in dual Lorentzian 3-spaceD13. Considering the causal character of the dual curve, sufficient and necessary conditions for spacelike curves to be dual Lorentzian spherical were given. Also, new sufficient and necessary conditions for non-null curves to be hyperbolic dual spherical were presented. Then, an insight on curves with null-principal normal is reported.
Coordinate Monitoring Technology in the Process of Incremental Launching Construction of Curved Steel Box Girder Bridge
Authors: Wang Haipeng , Wang Kai , Guo Nan
Published: June 2022

Based on the steel box girder curve incremental launching project of SW ramp bridge in Harbin East Third Ring Road, the geometric alignment and structural internal force of the steel box girder during the incremental launching process were monitored in the whole process. The curve incremental launching coordinate position control method was adopted, and the relevant parameters were modified according to the site construction situation and the initial stress conditions of the girders, and the corrected theoretical value was used as the control and evaluation basis of the monitoring value. The results showed that the original theoretical deflection value was −33.10 mm, the modified theoretical deflection value was −64.10 mm, and the actual monitoring value was −53.20 mm. The modified theoretical value agreed well with the monitoring value, and the error rate between the monitoring value and the theoretical value under each working condition was −17.82%∼14.48%. The geometric alignment and internal force of the steel box girder met the monitoring requirements, ensuring that the steel box girder can meet the design requirements under various working conditions.
Retrospective Study of Recurrence and Associated Factors of Type 2 Diabetes Treated at Adama General Hospital, Oromia, Ethiopia: A Comparison of Cox-PH and Shared Lognormal Frailty Models
Authors: Legesse Alemayehu
Published: June 2022

Background. Recovery from type 2 diabetes is frequently recurrent, as a single patient may recover from more than one over time. The goal of this study was to know the recurrent event (time to recovery) and associated factors of type 2 diabetes in Adama General Hospital, Ethiopia, by comparing shared lognormal frailty and Cox-PH models. Methods. A retrospective analysis of 302 type 2 diabetic patients (01, 2011–01, and 2016) was considered. Descriptive statistics were used to summarize the study variables. The standard Cox-proportional hazards model and a shared lognormal frailty model have been compared. The latter model with a 95% significance level was fitted, variables with

P
 value
<
0.
05

were considered significant, and the adjusted hazard ratio has been used to measure the strength of the risk. Results. About 56.6% of the patients recovered. The average recovery time was 33.53 (standard deviation, 20.404 ) weeks. Gender (adjusted HR = 1.168, 95% CI = (0.93, 1.46),

P
<
0.05

), family history (adjusted HR = 0.765, 95% CI = (0.59, 0.99),

P
<
0.05

), cholesterol level (adjusted HR = 0.738, 95% CI = (0.57, 0.96),

P
<
0.05

), alcohol use (adjusted HR = 0.698, 95% CI = (0.53, 0.92),

P
<
0.05

), and smoking cigarette (adjusted HR = 0.674, 95% CI = (0.51, 0.89),

P
<
0.05

) were statistically significant. The estimated frailty term’s variance was 0.426 (

P
 value
=
0.
028

). Also, the author presents a comparison study for the same data by using a model selection criterion and suggests a better model (shared lognormal frailty model). Conclusion. Finally, the median recovery time was 30 weeks. Female patients had a better chance of recovery than male patients. A shared lognormal frailty model outperformed the Cox-PH model in fitting the data and controlling event interdependence. There was risk heterogeneity among patients. Positive family history, high cholesterol level, alcohol use, and smoking have an inverse relationship with the overall likelihood of the patients’ recovery time. Therefore, future improvement measures against type 2 DM recovery should take all events (for example, the first, second, and third recovery in this study) and these identified factors into account.
Triangular Equilibria in R3BP under the Consideration of Yukawa Correction to Newtonian Potential
Authors: Idrisi M. Javed , Eshetie Teklehaimanot , Tilahun Tenaw , Kerebh Mitiku
Published: June 2022

We study the triangular equilibrium points in the framework of Yukawa correction to Newtonian potential in the circular restricted three-body problem. The effects of

α

and

λ

on the mean-motion of the primaries and on the existence and stability of triangular equilibrium points are analyzed, where

α
∈

−
1
,
1

is the coupling constant of Yukawa force to gravitational force, and

λ
∈

0

,

∞

is the range of Yukawa force. It is observed that as

λ
⟶
∞

, the mean-motion of the primaries

n
⟶

1
+
α

1
/
2

and as

λ
⟶
0

,

n
⟶
1

. Further, it is observed that the mean-motion is unity, i.e.,

n
=
1

for

α
=
0

,

n
>
1

if

α
>
0

and

n
<
1

when

α
<
0

. The triangular equilibria are not affected by

α

and

λ

and remain the same as in the classical case of restricted three-body problem. But,

α

and

λ

affect the stability of these triangular equilibria in linear sense. It is found that the triangular equilibria are stable for a critical mass parameter

μ

c

=

μ

0

+
f

α
,
λ

, where

μ

0

=
0.0385209
⋯

is the value of critical mass parameter in the classical case of restricted three-body problem. It is also observed that

μ

c

=

μ

0

either for

α
=
0

or

λ
=
0.618034

, and the critical mass parameter

μ

c

possesses maximum (

μ

c
max

) and minimum (

μ

c
min

) values in the intervals

−
1
<
α
<
0

and

0
<
α
<
1

, respectively, for

λ
=
1
/
3

.
Associations of Dietary Antioxidants with Glycated Hemoglobin and Insulin Sensitivity in Adults with and without Type 1 Diabetes
Authors: Basu Arpita , Alman Amy C. , Snell-Bergeon Janet K.
Published: June 2022

Type 1 diabetes (T1D) has been associated with increased risks of atherosclerotic cardiovascular disease, and poor glycemic control and oxidative stress play a major role in its pathology. There is a lack of data on the role of dietary antioxidant micronutrients, including vitamins and trace elements, in glycemic control in T1D. The aim of this study is to examine associations of dietary intakes of micronutrients with glycemic status. We report data from a cross-sectional analysis from the coronary artery calcification in type 1 diabetes (CACTI) study (

n
=
1257

; T1D:

n
=
568

; nondiabetic controls:

n
=
689

) collected between the years 2000 and 2002. Participants completed a validated food frequency questionnaire, a physical examination, and biochemical analyses. Linear regression was used to examine the associations of dietary antioxidant micronutrients with HbA1c and estimated insulin sensitivity (eIS) in models adjusted for relevant covariates and stratified by diabetes status. In adults with T1D, we observed higher dietary manganese intake associated with higher eIS in the model adjusted for age, sex, diabetes duration, and total calories. In nondiabetic controls, higher intake of manganese associated with lower HbA1c and higher eIS values that persisted in models adjusted for all relevant covariates. On the other hand, dietary copper revealed a positive association with HbA1c in models adjusted for all covariates, except BMI and plasma lipids. No associations were noted for vitamins C and E and dietary carotenoids in either group. These findings reveal dietary antioxidant micronutrients, especially trace elements such as copper and manganese deserve special attention in glycemic control in adults with T1D as well as in nondiabetic controls.This trial is register with NCT00005754.
A Theoretical Study of Reverse Roll Coating for a Non-Isothermal Third-Grade Fluid under Lubrication Approximation Theory
Authors: Ali Fateh , Zahid Muhammad , Hou Yanren , Manafian Jalil , Rana M. A. , Hajar Afandiyeva
Published: June 2022

The flow of non-Newtonian fluids is extremely important in a variety of industrial applications and processes, including painting, printing, and coating. The goal of this paper is to develop a mathematical model for an incompressible, non-isothermal third-grade fluid as it travels through a minor gap between two heated rolls that are revolving in the opposite direction. Using appropriate dimensionless parameters, the dimensionless version of the governing equations is constructed. To simplify the nondimensional form of the governing equations, the LAT (lubrication approximation theory) is applied. It is mentioned that the perturbation approach should be used. It is a very important tool in modern mathematical physics and practical fluid mechanics, and it is used a lot. Through perturbation techniques, exact solutions for velocity distribution, flow rate, temperature distribution, and pressure gradient are offered. To observe the flow pattern, streamlines are also drawn. Numerical outcomes of some substantial engineering quantities like flow rate, roll separation force, power input, and pressure distribution are found. Some outcomes are displayed graphically although others are presented in tabular form. We have observed that the third-grade parameters give a way to control velocity, pressure gradients, flow rate, and coating thickness. Further, increasing the velocities ratio values lowers the coating thickness on the web. Furthermore, the Brickman number has a significant influence on the temperature profile and has increased with the increase in the Brickman number. Both the model and the numerical calculations are in agreement with the viscous fluid model that is already present in the literature.
Smart Mobile Information Systems on the Key Systems of Blockchain Privacy Protection
Authors: Wei Xiaobo
Published: June 2022

In the process of data collaboration, the data source copyright, equity boundaries, and other issues must be ensured to ensure the data owner’s income rights. The data on the blockchain are transaction data. After the data are verified, they are added to the block by the node that has the right to keep accounts. Once the data are added to the blockchain, they cannot be deleted or changed, and only authorized query operations can be performed. The transaction records on the blockchain are completely public, and the fund transactions between accounts can reflect a lot of valuable information, especially some special accounts track the IP of transaction users through methods such as address reuse, taint analysis, and cluster analysis. At the same time, a credit contribution certification mechanism is established to ensure that the contributions are directly proportional to the rewards, and finally, a credit mechanism for data fraud is established. This paper mainly analyzes the key systems of privacy protection through research data and blockchain. The research results show that different companies conduct the Pailler homomorphic encryption of data and use the secure multiparty calculation to obtain the results. The execution of the whole process is controlled by a specific intelligent contract, and the records of the execution process are stored in the blockchain. It can be seen that the blockchain-based data distribution system changes the traditional data distribution mode so that the data source and the data user can interact directly, which promotes the maintenance of the system’s security and stability.
A Comparative Cross-Sectional Study of Coagulation Profiles and Platelet Parameters of Schistosoma mansoni-Infected Adults at Haik Primary Hospital, Northeast Ethiopia
Authors: Bisetegn Habtye , Feleke Daniel Getacher , Ebrahim Hussen , Tesfaye Melkam , Gedefie Alemu , Erkihun Yonas
Published: June 2022

Introduction. Schistosoma mansoni is an intravascular parasite that interacts with all components of the host blood. Nearly, 10% of S. mansoni-infected patients progress to severe hepatosplenic Schistosomiasis is characterized by periportal fibrosis, obstruction of intrahepatic veins, presinusoidal portal hypertension, and splenomegaly. Thus, this study aimed to compare the basic coagulation profiles and platelet parameters of S. mansoni-infected adults and noninfected individuals as controls at Haik Primary Hospital, Northeast Ethiopia. Methods. A comparative cross-sectional study was conducted at Haik Primary Hospital from April to June 2021. The diagnosis and intensity of S. mansoni infection was determined using the Kato–Katz technique. The coagulation profiles and platelet parameters were analyzed using coagulation and hematology analyzers. Data were analyzed using SPSS version 26.0. The Kolmogorov–Smirnov and Shapiro–Wilk tests were done to check the distribution of continuous variables. The Mann–Whitney U test was used to compare the coagulation profiles and platelet parameters. Spearman’s rank-order correlation was done to assess the correlation between the intensity of infection and coagulation profiles and platelet parameters. In all comparison, a

P

value <0.05 was considered statistically significant. Result. In this study, a total of 180 study participants (90 S. mansoni-infected adults and 90 controls) were included. Of the total S. mansoni-infected adults, 55.6%, 28.9%, 33, and 15.6% had light, moderate, and heavy intensity of infections, respectively. All S. mansoni-infected study participants had prolonged prothrombin time (PT) and international normalized ratio (INR). Moreover, about 80% of S. mansoni-infected adults had prolonged activated partial thromboplastin time (APTT). Thrombocytopenia was found in 26.7% of the S. mansoni-infected adults. The Mann–Whitney U test showed a statistically significant difference in coagulation profiles between S. mansoni-infected adults and healthy controls (

P

-value ≤0.001). The Kruskal–Wallis H-test showed a significant difference in PT, APTT, and INR between the intensity of infection and healthy controls (

P

-value <0.05). Conclusion. This study showed a prolonged coagulation time in S. mansoni-infected individuals. Thus, screening of schistosomiasis patients for hemostatic abnormalities and treating the underlying disorder is crucial.
Preparation and Sound Insulation Performance of Polystyrene Building Flame Retardant and Thermal Insulation Building Materials
Authors: Guo Qiulan
Published: June 2022

In this study, magnesium hydroxide (MH) was modified by sodium dodecylbenzene sulfonate (SDBS) to prepare modified magnesium hydroxide (MMH) flame retardant, which was mixed with polystyrene (PS) to obtain flame retardant PS composite plate. The micromorphology, mechanical properties, thermal stability, and flame retardancy of flame retardant PS composite plate were analyzed. The experimental results show that MMH is well dispersed in PS matrix, PS-MMH-3 has the best tensile strength and elongation at break, the limit oxygen index (LOI) is 44.3% higher than that of pure PS, and the combustion rate is slow, indicating that PS-MMH-3 has good flame retardant properties.
Extended Transportation Models Based on Picture Fuzzy Sets
Authors: Mehmood Muhammad Athar , Bashir Shahida
Published: June 2022

Picture fuzzy set (PFS) is an extension of intuitionistic fuzzy set, and it is capable to analyze the transportation problems that contain uncertain and vague information. PFSs are applicable in situations where human decisions demand more variety of responses: yes, abstain, no, and rejection which cannot be addressed in the traditional FSs and IFSs. In this paper, we propose a technique to solve fully picture fuzzy transportation problems (FPFTPs) which are based on picture fuzzy linear programming formulation. Fully picture fuzzy transportation problems are developed by considering all the variables and parameters as nonnegative trapezoidal picture fuzzy numbers. A ranking function is used to transform picture fuzzy numbers into crisp numbers. A model is presented to explain the suggested scheme. Finally, comparison analysis of fully picture fuzzy transportation model with fully intuitionistic fuzzy transportation model and fully fuzzy transportation model is presented with pictorial illustrations.
Virtual Reality Technology in Landscape Design at the Exit of Rail Transit Using Smart Sensors
Authors: Sun Chuan , Dong Li
Published: June 2022

The artistic thought of traditional garden landscape design has an important influence on garden art, and architectural theory and gardening theory are also inextricably linked. In modern gardens, traditional architecture lacks applicability to the construction of garden painting environment. Based on the background of modern gardens today, this paper studies the landscape design approaches that have the effect of painting in modern gardens, in order to provide references for modern gardens design. Virtual reality technology mainly provides users with a three-dimensional image environment through the use of simulation methods, which can truly reflect the changes and interactions of operating objects, thus forming a virtual world and establishing a relationship between users and the virtual world, interactive virtual 3D interactive interface. Based on the comparison of mainstream engine systems, this paper selects a suitable virtual reality system based on the characteristics of garden landscape design. On this basis, it further studies and researches the functions of the engine system selected by the research institute and explores the virtual reality system that meets the characteristics of creating garden landscape engineering. In the real work process, a three-dimensional virtual environment of the garden landscape is finally selected, so as to lay a solid foundation for applying virtual reality technology to garden landscape design, and strive to gain an advantage in the application field of virtual reality technology in this industry. Traffic congestion and frequent traffic accidents have become a major obstacle to urban development, the use of intelligent transportation systems to solve urban traffic problems has become the consensus of managers, so this paper uses intelligent sensor technology to schedule traffic flow. Experimental results show that virtual reality technology mainly uses simulation methods to give users a personal experience. The density of green space corridors simulated by VR technology can be increased from 1.25 km/km2 to 2.41 km/km2, which is more than doubled, which significantly improves the connectivity of green spaces and effectively improves the ecological functions of green spaces. Engineers, owners, and the public can see the final design effect in real time from any angle and can also interact with the flowers and trees in the scene to understand the design concept of landscape architects more comprehensively, thereby enhancing publicity effect, to achieve fast and effective dissemination. It is beneficial for users to really participate in the project design. The application prospect will be very broad.
Key Technology of Communication Equipment Fingerprint Recognition Based on Intelligent Feature Extraction Algorithm
Authors: Gao Meizhen , Li Yunquan , Gao Yetong
Published: June 2022

The rapid development of communication and computer has brought many application scenarios to the fingerprint identification technology of communication equipment. The technology is of great significance in electronic countermeasures, wireless network security, and other fields and has been widely studied in recent years. The fingerprint identification technology of communication equipment is mainly based on the fingerprint characteristics represented on the transmitted signals of the equipment, which are different from other devices, and the connection between the characteristics and the hardware equipment is established, so as to realize the purpose of identifying the communication equipment. In this paper, the author studies the key technologies related to fingerprint recognition of communication equipment, including signal acquisition, signal feature extraction, and classifier design, and transient signal recognition equipment. In this paper, the integrated learning and deep learning based on fingerprint recognition are taken as the main research contents of communication equipment, and the fingerprint recognition scheme of communication equipment is given; the proposed scheme is verified by the measured data. Aiming at the transient signal of communication equipment, an algorithm using the short-term periodicity of signal is presented. The feature extraction of steady-state signal is realized. The autoencoder feature and four kinds of integral bispectrum feature are analyzed and visualized. Research on communication equipment individual recognition technology is based on ensemble learning. An individual recognition scheme for communication devices based on Extreme Gradient Boosting (XGBoost) classification model is studied. The Gradient Boosting Decision Tree (GBDT) model with different parameters was used as the primary learner of stacking classifier. The steady-state signal recognition of mobile phones based on deep learning is studied. The results show that the stacking recognition rate improved by about 2% compared with GBDT using multiple GBDT models with different parameters as the primary learner.
Effect of Trichoderma-Based Biofertilizers on the Flower and Fruit Pattern of Horned Melon (Cucumis metuliferus E. Mey. ex Naudin)
Authors: Mutetwa Moses , Chagonda Ignatius , Gwaziwa Tafadzwa , Mangezi Pamela , Midzi Tapfumaneyi , Sithole Lawrence , Mtaita Tuarira , Masaka Johnson , Muziri Tavagwisa
Published: June 2022

The lack of agronomic information is one of the various reasons given for the failure of indigenous vegetables to move from subsistence plants of restricted use to vegetables that are considerably researched, utilized, available, and commercially aggressive. A greenhouse study was conducted at Midlands State University’s Department of Horticulture and Agronomy to consider the impact of Trichoderma biofertilizer at different stages on the overall performance of horned melon (Cucumis metuliferus). A complete randomized block design (CRBD) was used for this greenhouse experiment. Four Trichoderma-based biofertilizer treatments (0.1 g/pot, 0.2 g/pot, 0.3 g/pot, and 0.4 g/pot) and a control treatment (0.0 g/pot) in four replications were laid down. Inoculation by way of biofertilizer registered significant (

p
<
0.05

) results as a greater number of male flowers were recorded. Higher rates of biofertilizers of 0.3 g/pot and 0.4 g/pot gave more flowers, 10.75 and 12.25, respectively, versus lower application rates of 0.1 g/pot and 0.2 g/pot with 6.25 and 6.50 flowers, respectively. The days to flowering increased from 0.0 g/pot (44.75 days) to 0.4 g/pot (49.00 days). Time taken to fruiting was affected significantly (

p
<
0.05

) with the application of the biofertilizer. The number of fruits per plant followed the same trend of number of female flowers along the main stem. The number of small fruits increased numerically from 0.0 g/pot (0.5 fruits) to 0.4 g/pot (1.5 fruits) but did not differ (

p
>
0.05

) statistically between all treatments. The results of this current study indicate that the Trichoderma-based biofertilizer significantly affects the flowering pattern and fruiting characteristics of horned melon at different application rates. Further investigations need to be conducted to reveal the potential derived from the Trichoderma-based biofertilizer in the production of horned melon.
On Adjacency Metric Dimension of Some Families of Graph
Authors: Koam Ali N. A. , Ahmad Ali , Azeem Muhammad , Khalil Adnan , Nadeem Muhammad Faisal
Published: June 2022

Metric dimension of a graph is a well-studied concept. Recently, adjacency metric dimension of graph has been introduced. A set

Q

a

⊂
V

G

is considered to be an adjacency metric generator for

G

if

u

1

,

u

2

∈
V
\

Q

a

(supposing each pair); there must exist a vertex

q
∈

Q

a

along with the condition that

q

is indeed adjacent to one of

u

1

,

u

2

. The minimum number of elements in adjacency metric generator is the adjacency metric dimension of

G

, denoted by

di

m

a

G

.

In this work, we compute exact values of the adjacency metric dimension of circulant graph

C

n

1
,
2

, Möbius ladder, hexagonal Möbius ladder, and the ladder graph.
How Great Is the Level of Youth Cultural Sensitivity? A Multicultural Education from One Ethnic in Indonesia
Authors: Harmi Hendra , Ramdhani Muhammad Iqbal , Amalia Shynta , Apriani Eka , Syafryadin Syafryadin , Supardan Dadan , Zarin Ismat
Published: June 2022

Indonesia is a multiethnic and cosmopolitan country. To realize a multicultural society, the variety of the Indonesian nation is employed as a feature, as the Indonesian nation’s identity. Different cultures complement each other, do not stand alone, and are even capable of adapting (flexibly) to each other in the arena of daily life. Musi Rawas Utara is one of the regencies in South Sumatra Province, Indonesia, with a diversified community in terms of religion and race. Cultural, religious, political ambitions, economic divisions, and educational distinctions are among the most widely felt throughout Indonesia, particularly in the Musi Rawas region. The goal of this study was to look at the intercultural understanding of ethnic youngsters in the Musi Rawas area. The demographics of this study include all youth ethnic groups in the Musi Rawas area. A purposive sample was used, with 75 participants drawn from three villages in Musi Rawas Utara Regency, South Sumatra. A nontest strategy was used to collect data in the form of a questionnaire. The research tool employed in this study was a questionnaire with four response options: strongly agree, agree, disagree, and strongly disagree. In this sense, it may be argued that the youth ethnic groups, Orang Rimba, in Musi Rawas Utara, have a good understanding of multiculturalism.
Comprehensive Rehabilitation Therapy Plus Glucosamine Hydrochloride for Exercise-Induced Knee Injuries and the Effect on Knee Function of Patients
Authors: Liu Na , Wang Binggang
Published: June 2022

Objective. To assess the application value of comprehensive rehabilitation therapy plus glucosamine hydrochloride for exercise-induced knee injuries and its effect on knee function. Methods. A total of 96 patients with an exercise-induced knee injury who were admitted to our hospital from February 2019 to February 202 were recruited and assigned at a ratio of 1 : 1 with matched general information to a control group (n = 45) or an experimental group (n = 51). Both groups of patients received comprehensive rehabilitation therapy, and the patients in the experimental group were daily given additional glucosamine hydrochloride tablets for 8 weeks. Results. The experimental group showed a higher treatment efficacy than the control group (

P
<
0.001

). After the treatment, the VAS scores and C-reactive protein of the two groups showed a decline, with a lower result in the experimental group than in the control group (

P
<
0.001

). The Lysholm knee scores were increased in the two groups after the treatment, and the experimental group had a higher score (

P
<
0.001

). After the treatment, patients of both groups showed reduced five-times-sit-to-stand-test (FTSST) results, with a better outcome obtained in the experimental group (

P
<
0.001

). Conclusion. Comprehensive rehabilitation therapy plus glucosamine hydrochloride effectively improves the clinical efficacy of exercise-induced knee joint injuries and enhances the knee joint rehabilitation of the patients.
Data Visualization and Interaction of Urban Traffic Logistics Management System Using WebGIS
Authors: Li Zhaodi , Li Dan
Published: June 2022

At present, the large amount of data generated by transportation and logistics in cities brings great difficulties to data management and operation. The purpose is to explore the applicability of WebGIS and expand the application of intelligent interactive urban traffic logistics management. An urban traffic logistics management system is designed for urban traffic route assignment and intelligent interaction based on the WebGIS system and the basic principles and related algorithms of urban traffic route assignment. Then, the operation of the system under different shortest path algorithms and different path assignment algorithms is discussed. As a result, the Dijkstra algorithm runs faster than the Floyd algorithm. The comparison of three different road assignment algorithms shows that the no road assignment algorithm has the smallest average time consumption, which is 264.43 ms. The running time of the continuous average algorithm is the same as that of the user balance algorithm. The WebGIS system has practical application value compared with the TransCAD system and Cube system. This article proposes that the interactive function of the system can be used normally. The vehicle information of the test sample points can be displayed, and the function realization effect is good. The research results can provide scientific references for the follow-up research on intelligent transportation.
Effect of Endoscopic Retrograde Cholangiopancreatography Lithotomy Combined with Laparoscopic Cholecystectomy on Pain and Prognosis of Patients with Gallstones and Extrahepatic Bile Duct Stones
Authors: Zhao Hui , Zhang Jian
Published: June 2022

Objective. The researchers aim to assess how endoscopic retrograde cholangiopancreatography lithotomy and laparoscopic cholecystectomy affected pain and prognosis in individuals with gallstones and extrahepatic bile duct stones. Methods. Researchers studied 100 persons with gallstones and extrahepatic bile duct stones from January 2016 to August 2021. They were split into two groups: control and observation. The control group underwent open cholecystectomy + choledocholithotomy + T-tube drainage. There were ERCP + lithotomy + Laparoscopic cholecystectomy procedures conducted on the observation group of patients (LC). The operation time, incision size, and bleeding volume; stone clearance rate and stone recurrence rate; visual analogue scale (VAS); Eating time, exhaust time, out of bed activity time, and postoperative hospital stay; the two groups’ difficulties were contrasted and studied. Results. The observation group’s operation duration was much longer than the control group’s, and the incision size and bleeding volume were significantly reduced in the observation group. When it came to recurrence, there was a significant difference between the observation group (2.0%) and the control group (4.0%), even though stone clearance did not differ substantially (20.00%). The VAS scores 3 and 7 days after surgery were significantly different between the observation and control groups. The observation group’s eating time, exhaustion, activity time, and postoperative hospital stay were much shorter than the control group’s; complications occurred at a lower rate (20%) in the observation group than in the control group (34%). Conclusion. When gallstones and extrahepatic bile-duct stones are removed using laparoscopic lithotomy and laparoscopic cystoscopy (LC), the operation indices are improved and the risk of recurrence of stones is reduced and reducing the occurrence of complications, all of which improve patient outcomes and deserve to be considered a clinical reference.
Ulam–Hyers Stability for a Class of Hilfer-Type Fractional Stochastic Differential Equations
Authors: Song Meiling , Luo Zhiguo
Published: June 2022

In this work, we study a class of Hilfer-type fractional stochastic differential equations (HFSDEs). By Laplace transform and its inverse, we obtain a mild solution to HFSDEs. Furthermore, we research the existence and uniqueness of solutions to the addressed equations. Subsequently, we explore the Ulam–Hyers (U–H) stability of the considered system by the Picard iteration. Finally, we verify the correctness of the theoretical results with an example.
Clinical Factors and Outcomes When Real-World Heart Teams Overruled STS Risk Scores in TAVR Cases
Authors: King Jackson M. , Black Morgan T. , Jin Ruyun , Grunkemeier Gary L. , Reynolds Branden R. , Curtis Brydan D. , Hodson Robert W. , Strehl Erika A. , Gafoor Sameer A. , Forrester Matthew D. , Cox Emily J. , Ring Michael E.
Published: June 2022

Objectives. This study was conducted to determine why heart teams recommended transcatheter aortic valve replacement (TAVR) versus surgical AVR (SAVR) for patients at low predicted risk of mortality (PROM) and describe outcomes of these cases. Background. Historically, referral to TAVR was based predominately on the Society of Thoracic Surgeons (STS) risk model’s PROM >3%. In selected cases, heart teams had latitude to overrule these scores. The clinical reasons and outcomes for these cases are unclear. Methods. Retrospective data were gathered for all TAVR and SAVR cases conducted by 9 hospitals between 2013 and 2017. Results. Cases included TAVR patients with STS PROM >3% (n = 2,711) and ≤3% (n = 415) and SAVR with STS PROM ≤3% (n = 1,438). Leading reasons for recommending TAVR in the PROM ≤3% group were frailty (57%), hostile chest (22%), severe lung disease (16%), and morbid obesity (13%), and 44% of cases had multiple reasons. Most postoperative and 30-day outcomes were similar between TAVR groups, but the STS PROM ≤3% group had a one-day shorter length of stay (2.5 ± 3.4 vs. 3.5 ± 4.7 days;

p
≤
0.001

) and higher one-year survival (91.6% vs. 86.0%,

p
=
0.002

). In patients with STS PROM ≤3%, 30-day mortality was higher for TAVR versus SAVR (2.0% vs. 0.6%;

p
<
0.001

). Conclusions. Heart teams recommended TAVR in patients with STS PROM ≤3% primarily due to frailty, hostile chest, severe lung disease, and/or morbid obesity. Similar postoperative outcomes between these patients and those with STS PROM >3% suggest that decisions to overrule STS PROM ≤3% were merited and may have reduced SAVR 30-day mortality rate.
Interrogation of T Cell–enriched Tumors Reveals Prognostic and Immunotherapeutic Implications of Polyamine Metabolism
Authors: Harbison R. Alex , Pandey Rajeev , Considine Michael , Leone Robert D. , Murray-Stewart Tracy , Erbe Rossin , Mandal Raj , Burns Mark , Casero Robert A. , Seiwert Tanguy , Fakhry Carole , Pardoll Drew , Fertig Elana , Powell Jonathan D.
Published: June 2022

Metabolic features of the tumor microenvironment (TME) antagonize antitumor immunity. We hypothesized that T cell–infiltrated (Thi) tumors with a known antigen should exhibit superior clinical outcomes, though some fare worse given unfavorable metabolic features leveraging T cell–infiltrated (Thi), human papillomavirus–related (HPV+) head and neck squamous cell carcinomas (HNSC) to test this hypothesis. Expression of 2,520 metabolic genes was analyzed among Thi HPV+ HNSCs stratified by high-risk molecular subtype. RNA sequencing (RNA-seq) data from The Cancer Genome Atlas (TCGA; 10 cancer types), single-cell RNA-seq data, and an immunotherapy-treated melanoma cohort were used to test the association between metabolic gene expression and clinical outcomes and contribution of tumor versus stromal cells to metabolic gene expression. Polyamine (PA) metabolism genes were overexpressed in high-risk, Thi HPV+ HNSCs. Genes involved in PA biosynthesis and transport were associated with T-cell infiltration, recurrent or persistent cancer, overall survival status, primary site, molecular subtype, and MYC genomic alterations. PA biogenesis gene sets were associated with tumor-intrinsic features while myeloid cells in HPV+ HNSCs were enriched in PA catabolism, regulatory, transport, putrescine, and spermidine gene set expression. PA gene set expression also correlated with IFNγ or cytotoxic T-cell single-sample gene set enrichment analysis (ssGSEA) scores across TCGA tumor types. PA transport ssGSEA scores were associated with poor survival whereas putrescine ssGSEA scores portended better survival for several tumor types. Thi melanomas enriched in PA synthesis or combined gene set expression exhibited worse anti-PD-1 responses. These data address hurdles to antitumor immunity warranting further investigation of divergent PA metabolism in the TME.

Significance:

Despite the presence of tumor-infiltrating lymphocytes and antigen, antitumor immunity is often insufficient in tumor control. We leverage HPV-related head and neck cancers to identify metabolic challenges to antitumor immune responses. PA metabolism is associated with tumor-intrinsic features while the myeloid compartment exhibits enriched PA regulatory gene expression.
Late Onset of Cardiac Metastasis of a Melanoma following Nivolumab Immunotherapy
Authors: Nakamura Kenta , Koga Hiroshi , Takazawa Yuko , Omodaka Toshikazu , Kiniwa Yukiko , Okuyama Ryuhei
Published: June 2022

In this report, we present a case of cardiac metastasis of a malignant melanoma originating from the nasal cavity and presenting with cardiac tamponade detected during immunotherapy. The patient was a 66-year-old man diagnosed with malignant melanoma of the right nasal cavity 4 years ago. Two years ago, the size of the melanoma increased making it unresectable; therefore, he was treated thrice with a combination therapy of nivolumab and ipilimumab. Subsequently, the treatment was changed to single-agent nivolumab therapy, which was continuously administered for one and a half years. Imaging evaluation conducted every 3 months showed no distant metastasis. General malaise occurred, and the patient visited our department. He was diagnosed to have cardiac tamponade using echocardiography and was admitted to the emergency department of our hospital. He underwent pericardiocentesis. Computed tomography revealed an irregular mass extending from the right atrium to the inferior vena cava, and malignant melanoma metastasis was diagnosed through catheter biopsy and histology. As the tumor was unresectable, radiotherapy (30 Gy/10 fractions) and dacarbazine administration were performed on the right atrial mass, and pericardial effusion improved.
SOX Genes and Their Role in Disorders of Sex Development
Authors: Sreenivasan Rajini , Gonen Nitzan , Sinclair Andrew
Published: June 2022

SOX genesare master regulatory genes controlling development and are fundamental to the establishment of sex determination in a multitude of organisms. The discovery of the master sex-determining gene SRY in 1990 was pivotal for the understanding of how testis development is initiated in mammals. With this discovery, an entire family of SOX factors were uncovered that play crucial roles in cell fate decisions during development. The importance of SOX genes in human reproductive development is evident from the various disorders of sex development (DSD) upon loss or overexpression of SOX gene function. Here, we review the roles that SOX genes play in gonad development and their involvement in DSD. We start with an overview of sex determination and differentiation, DSDs, and the SOX gene family and function. We then provide detailed information and discussion on SOX genes that have been implicated in DSDs, both at the gene and regulatory level. These include SRY, SOX9, SOX3, SOX8, and SOX10. This review provides insights on the crucial balance of SOX gene expression levels needed for gonad development and maintenance and how changes in these levels can lead to DSDs.
Stratifying Future Stroke Risk with Incidentally Discovered White Matter Disease Severity and Covert Brain Infarct Site
Authors: Wang Andy Y. , Leung Lester Y. , Puttock Eric J. , Luetmer Patrick H. , Kallmes David F. , Nelson Jason , Fu Sunyang , Zheng Chengyi , Liu Hongfang , Chen Wansu , Kent David M.
Published: June 2022

Background: Covert cerebrovascular disease (CCD) includes white matter disease (WMD) and covert brain infarction (CBI). Incidentally discovered CCD is associated with increased risk of subsequent symptomatic stroke. However, it is unknown whether the severity of WMD or the location of CBI predicts risk. Objectives: The aim of this study was to examine the association of incidentally discovered WMD severity and CBI location with risk of subsequent symptomatic stroke. Method: This retrospective cohort study includes patients aged ≥50 years old in the Kaiser Permanente Southern California health system who received neuroimaging for a nonstroke indication between 2009 and 2019. Incidental CBI and WMD were identified via natural language processing of the neuroimage report, and WMD severity was classified into grades. Results: A total of 261,960 patients received neuroimaging; 78,555 patients (30.0%) were identified to have incidental WMD and 12,857 patients (4.9%) to have incidental CBI. Increasing WMD severity is associated with an increased incidence rate of future stroke. However, the stroke incidence rate in CT-identified WMD is higher at each level of severity compared to rates in MRI-identified WMD. Patients with mild WMD via CT have a stroke incidence rate of 24.9 per 1,000 person-years, similar to that of patients with severe WMD via MRI. Among incidentally discovered CBI patients with a determined CBI location, 97.9% are subcortical rather than cortical infarcts. CBI confers a similar risk of future stroke, whether cortical or subcortical or whether MRI- or CT-detected. Conclusions: Increasing severity of incidental WMD is associated with an increased risk of future symptomatic stroke, dependent on the imaging modality. Subcortical and cortical CBI conferred similar risks.
Regorafenib beyond the Second Line in Relapsed Glioblastoma: A Case Report and Literature Review
Authors: Pirozzi Mario , Caterino Marianna , Facchini Sergio , Zotta Alessia , Messina Gaetana , Rauso Raffaele , Sica Antonello , Sciano Donato , Facchini Gaetano , Orditura Michele , Somma Teresa , Maiuri Francesco , Cappabianca Paolo , Ciardiello Fortunato , Fasano Morena
Published: June 2022

Glioblastoma multiforme (GBM) is one of the most frequent and aggressive primary tumors in the central nervous system, representing more than 60% of all brain tumors in adults. Primary GBM remains incurable with a poor prognosis both for limited therapeutic alternatives and for a high risk of progression or recurrence. In fact, at recurrence, the few treatment options available, and often characterized by limited effectiveness, have always been an Achilles’ heel. The recent approval of second line of regorafenib, a multikinase inhibitor, has given hope after several years of darkness for new therapies in the treatment of GBM. Indeed, in the REGOMA trial, a phase 2 study, regorafenib was the first drug to show a statistically significant improvement in median overall survival compared with lomustine group, usually used in the second-line treatment after temozolomide failure. We report a case of a 43-year-old patient affected by GBM in treatment with regorafenib in third line of therapy with good disease control and long PFS.
Febrile Ulceronecrotic Mucha-Habermann Disease: A Case Report and a Systematic Review
Authors: Tang Ping , Chen Jing-si , Wang Hua , Yang Huan
Published: June 2022

The characteristics and treatments of febrile ulceronecrotic Mucha-Habermann disease (FUMHD) are not well-understood. We reported a FUMHD case, and searched Medline, Embase, Pubmed, Scopus, and Web of Science from inception to June 16, 2021, to perform a systematic review to synthesize its characteristics and treatments. Seventy-eight reports, including 84 people were eligible. Most of them were male (62/83, 74.7%), with high fever state (50/80, 62.5% had a high fever of 39°C or above), and with more positive skin bacterial cultures (31/41, 75.6%). Adults were associated with a higher risk of death (OR = 12.976, 95% CI: 1.049, 160.504, p = 0.046), but not positive blood bacterial cultures (p = 0.102). Systematic corticosteroids combination with other immunosuppressants (methotrexate or cyclosporine) were associated with significantly more effective cases (26/31 = 83.9%, χ2 = 4.065, p = 0.044). Furthermore, no significant differences between the low-dose and high-dose systematic corticosteroid groups were detected in treatment validation (p > 0.05). Overall, FUMHD was associated with male patients, high fever, and positive skin bacterial cultures. Early combination therapy with lower doses of corticosteroids and methotrexate or cyclosporine may be an optimal choice for the treatment of FUMHD.
Chronische Suizidgedanken: Ein Behandlungsvorschlag
Authors: Teismann Tobias , Koban Christoph
Published: June 2022

Einleitung: Chronische Suizidgedanken sind in der klinischen Praxis verbreitet. Gleichwohl finden sich in der Literatur nur wenige Hinweise zum therapeutischen Umgang mit chronischen Suizidgedanken. Methode: Aufbauend auf der Idee, dass Verstärkungsprozesse für die Persistenz von Suizidgedanken hochrelevant sind und anhaltende Suizidgedanken für Betroffene teils positiv konnotiert sind, wird im vorliegenden Artikel ein Behandlungsvorschlag abgeleitet. Ergebnisse: Hierbei werden Elemente der explizit-fokussierten Ambivalenzarbeit verknüpft mit Therapieelementen aus der metakognitiven Therapie bzw. der Akzeptanz- und Commitment-Therapie. Diskussion/Schlussfolgerung: Es wird betont, dass der Umgang mit chronischen Suizidgedanken eine andere therapeutische Herangehensweise erfordert als der Umgang mit akuten Suizidgedanken.
Homalenchodes, a new genus of Serropalpini from mid-Cretaceous amber of northern Myanmar (Coleoptera: Tenebrionoidea: Melandryidae)
Authors: LI YAN-DA , HSIAO YUN , YOSHITOMI HIROYUKI , HUANG DI-YING , CAI CHEN-YANG
Published: June 2022

A new fossil genus and species of the family Melandryidae, Homalenchodes jarzembowskii Li, Hsiao, Yoshitomi & Cai gen. et sp. nov., is described and illustrated from the mid-Cretaceous Burmese amber. Homalenchodes is likely closely related to the serropalpin genus Enchodes LeConte, based on their simple maxillary palps, complete prosternal process, exposed protrochantins, ventrally lobed penultimate metatarsomeres, and absence of transverse rows of bristles or spines along the meso- and metatibiae.