bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Table S9 from Colorectal Cancer Cell Lines Are Representative Models of the Main Molecular Subtypes of Primary Cancer
Authors: Mouradov Dmitri , Sloggett Clare , Jorissen Robert N. , Love Christopher G. , Li Shan , Burgess Antony W. , Arango Diego , Strausberg Robert L. , Buchanan Daniel , Wormald Samuel , O'Connor Liam , Wilding Jennifer L. , Bicknell David , Tomlinson Ian P.M. , Bodmer Walter F. , Mariadason John M. , Sieber Oliver M.
Published: March 2023

Simulation of tumor mutational heterogeneity. Estimates are for the minimum number of cell replications required for two randomly chosen cells to possess the number of mutational differences observed in paired cell lines at a greater than 99% probability. Data were simulated using fixed mutation probabilities of 10-8 per base per cell replication for non-hypermutated and 10-6 for hypermutated MSI-H tumors.
Supplemental Movie 4 from AXL Inhibition Sensitizes Mesenchymal Cancer Cells to Antimitotic Drugs
Authors: Wilson Catherine , Ye Xiaofen , Pham Thinh , Lin Eva , Chan Sara , McNamara Erin , Neve Richard M. , Belmont Lisa , Koeppen Hartmut , Yauch Robert L. , Ashkenazi Avi , Settleman Jeff
Published: March 2023

Timelapse movie of HeLa cells treated with docetaxel (3nM) in combination with R428 (1ÃŽÂ¼M).
Supplementary Table S7 from Colorectal Cancer Cell Lines Are Representative Models of the Main Molecular Subtypes of Primary Cancer
Authors: Mouradov Dmitri , Sloggett Clare , Jorissen Robert N. , Love Christopher G. , Li Shan , Burgess Antony W. , Arango Diego , Strausberg Robert L. , Buchanan Daniel , Wormald Samuel , O'Connor Liam , Wilding Jennifer L. , Bicknell David , Tomlinson Ian P.M. , Bodmer Walter F. , Mariadason John M. , Sieber Oliver M.
Published: March 2023

Top 5% of mutated genes based on the proportion of affected samples in CRC cell lines and TCGA-analyzed primary cancers for non-hypermutated and hypermutated MSI-H samples.
Supplemental Movie 2 from AXL Inhibition Sensitizes Mesenchymal Cancer Cells to Antimitotic Drugs
Authors: Wilson Catherine , Ye Xiaofen , Pham Thinh , Lin Eva , Chan Sara , McNamara Erin , Neve Richard M. , Belmont Lisa , Koeppen Hartmut , Yauch Robert L. , Ashkenazi Avi , Settleman Jeff
Published: March 2023

Timelapse movie of HeLa cells treated with R428 (1ÃŽÂ¼M).
Supplementary Table S3 from Colorectal Cancer Cell Lines Are Representative Models of the Main Molecular Subtypes of Primary Cancer
Authors: Mouradov Dmitri , Sloggett Clare , Jorissen Robert N. , Love Christopher G. , Li Shan , Burgess Antony W. , Arango Diego , Strausberg Robert L. , Buchanan Daniel , Wormald Samuel , O'Connor Liam , Wilding Jennifer L. , Bicknell David , Tomlinson Ian P.M. , Bodmer Walter F. , Mariadason John M. , Sieber Oliver M.
Published: March 2023

Sanger sequencing validation for mutations detected by exome-capture sequencing for 12 genes in 43 CRC cell lines. Genes comprised APC, CTNNB1, KRAS, BRAF, NRAS, PIK3CA, PTEN, SMAD2, SMAD3, SMAD4, FBXW7 and TP53. Cell lines included C32, C70, C80, C84, C99, C106, CACO2, COLO201, COLO205, COLO320-DM, COLO678, DLD1, HCA7, HCC2998, HCT8, HCT15, HCT116, HRA19, HT29, HT55, LIM1215, LIM1899, LIM2099, LIM2405, LIM2551, LOVO, LS174T, LS180, LS411, LS513, RKO, RW2982, RW7213, SW48, SW403, SW480, SW620, SW837, SW948, SW1116, SW1222, T84 and VACO4S.
Supplemental Figures S1-S11, Datasets 1-3 from AXL Inhibition Sensitizes Mesenchymal Cancer Cells to Antimitotic Drugs
Authors: Wilson Catherine , Ye Xiaofen , Pham Thinh , Lin Eva , Chan Sara , McNamara Erin , Neve Richard M. , Belmont Lisa , Koeppen Hartmut , Yauch Robert L. , Ashkenazi Avi , Settleman Jeff
Published: March 2023

Supplemental Figures S1-S11. Figure S1. AXL and GAS6 expression correlates with a mesenchymal signature. Figure S2. AXL staining in TNBC tissues samples. Figure S3. TGF-ÃŽÂ²-induced EMT is reversible, and TKI resistance upon EMT is not due to drug efflux. Figure S4. AXL inhibitor R428 suppresses GAS6-induced pAXL, downstream signaling and invasion capacity. Figure S5: Inhibition of AXL does not re-sensitize erlotinib-resistant cells. Figure S6: AXL over-expression or inhibition does not alter erlotinib sensitivity in the parental HCC827 cell line. Figure S7: Summary of Bliss scores and activity of MP-470, Erlotinib and Docetaxel (DTX) or combination treatment. Figure S8. R428 synergistically interacts with anti-mitotic agents and not with Doxorubicin or Cisplatin to reduce cell viability. Figure S9. AXL inhibition in combination with anti-mitotic agents promotes mitotic death. Figure S10. Suppression of pAKT, pS6 and pCDC2 following AXL inhibition. Figure S11: AXL knock-down increases p21 expression. Table S1. Mesenchymal PC9 cells are cross-resistant to a number of anti-cancer agents.
Supplementary Table S2 from Colorectal Cancer Cell Lines Are Representative Models of the Main Molecular Subtypes of Primary Cancer
Authors: Mouradov Dmitri , Sloggett Clare , Jorissen Robert N. , Love Christopher G. , Li Shan , Burgess Antony W. , Arango Diego , Strausberg Robert L. , Buchanan Daniel , Wormald Samuel , O'Connor Liam , Wilding Jennifer L. , Bicknell David , Tomlinson Ian P.M. , Bodmer Walter F. , Mariadason John M. , Sieber Oliver M.
Published: March 2023

Somatic mutations in protein-coding genes identified in 70 CRC cell lines using exome-capture sequencing.
Supplemental Dataset 2 from AXL Inhibition Sensitizes Mesenchymal Cancer Cells to Antimitotic Drugs
Authors: Wilson Catherine , Ye Xiaofen , Pham Thinh , Lin Eva , Chan Sara , McNamara Erin , Neve Richard M. , Belmont Lisa , Koeppen Hartmut , Yauch Robert L. , Ashkenazi Avi , Settleman Jeff
Published: March 2023

Supplemental Dataset 2. Kinome profile with 1000nM R428
Supplementary Table 9 from Colorectal Cancer Cell Lines Are Representative Models of the Main Molecular Subtypes of Primary Cancer
Authors: Mouradov Dmitri , Sloggett Clare , Jorissen Robert N. , Love Christopher G. , Li Shan , Burgess Antony W. , Arango Diego , Strausberg Robert L. , Buchanan Daniel , Wormald Samuel , O'Connor Liam , Wilding Jennifer L. , Bicknell David , Tomlinson Ian P.M. , Bodmer Walter F. , Mariadason John M. , Sieber Oliver M.
Published: March 2023

XLSX file - 9KB, Simulation of tumor mutational heterogeneity. Estimates are for the minimum number of cell replications required for two randomly chosen cells to possess the number of mutational differences observed in paired cell lines at a greater than 99% probability. Data were simulated using fixed mutation probabilities of 10-8 per base per cell replication for non-hypermutated and 10-6 for hypermutated MSI-H tumors.
Supplemental Dataset 1 from AXL Inhibition Sensitizes Mesenchymal Cancer Cells to Antimitotic Drugs
Authors: Wilson Catherine , Ye Xiaofen , Pham Thinh , Lin Eva , Chan Sara , McNamara Erin , Neve Richard M. , Belmont Lisa , Koeppen Hartmut , Yauch Robert L. , Ashkenazi Avi , Settleman Jeff
Published: March 2023

Supplemental Dataset 1. Expression of AXL, GAS6, Vimentin and E-Cadherin in 644 human cancer cell line using RNAseq technology.
Supplementary Table 7 from Colorectal Cancer Cell Lines Are Representative Models of the Main Molecular Subtypes of Primary Cancer
Authors: Mouradov Dmitri , Sloggett Clare , Jorissen Robert N. , Love Christopher G. , Li Shan , Burgess Antony W. , Arango Diego , Strausberg Robert L. , Buchanan Daniel , Wormald Samuel , O'Connor Liam , Wilding Jennifer L. , Bicknell David , Tomlinson Ian P.M. , Bodmer Walter F. , Mariadason John M. , Sieber Oliver M.
Published: March 2023

XLSX file - 90KB, Top 5% of mutated genes based on the proportion of affected samples in CRC cell lines and TCGA-analyzed primary cancers for non-hypermutated and hypermutated MSI-H samples.
Supplementary Table 5 from Colorectal Cancer Cell Lines Are Representative Models of the Main Molecular Subtypes of Primary Cancer
Authors: Mouradov Dmitri , Sloggett Clare , Jorissen Robert N. , Love Christopher G. , Li Shan , Burgess Antony W. , Arango Diego , Strausberg Robert L. , Buchanan Daniel , Wormald Samuel , O'Connor Liam , Wilding Jennifer L. , Bicknell David , Tomlinson Ian P.M. , Bodmer Walter F. , Mariadason John M. , Sieber Oliver M.
Published: March 2023

XLSX file - 50KB, Significantly altered focal regions of chromosomal deletion or gain/amplification for 63 unique CRC cell lines and 213 TCGA-analyzed primary cancers stratified into non-hypermutated and hypermutated MSI-H cases. Minimal focal regions were deduced using OncoSNP v2.18 suite and GISTIC2.0.
Supplemental Figures 1-8 from ERK Mutations Confer Resistance to Mitogen-Activated Protein Kinase Pathway Inhibitors
Authors: Goetz Eva M. , Ghandi Mahmoud , Treacy Daniel J. , Wagle Nikhil , Garraway Levi A.
Published: March 2023

Supplemental Figures 1-8. Fig. S1. The landscape of mutations of putative ERK1/2 resistance alleles; Fig. S2. Expression and signaling induced by validated ERK resistance alleles; Fig. S3. ERK2 signaling and kinase activity assays with the ERK inhibitor SCH772984; Fig. S4. Analysis of co-mutated ERK1/2 alterations; Fig. S5. Structural localization of RAF/MEK inhibitor alleles; Fig. S6. Drug sensitivity of non-validating alleles; Fig. S7. Drug sensitivity assays of RAF/MEK inhibitor resistance alleles; Fig. S8. Viability of ERK1/2 resistance alleles in WM266.4 cells
Supplementary Table 4 from Colorectal Cancer Cell Lines Are Representative Models of the Main Molecular Subtypes of Primary Cancer
Authors: Mouradov Dmitri , Sloggett Clare , Jorissen Robert N. , Love Christopher G. , Li Shan , Burgess Antony W. , Arango Diego , Strausberg Robert L. , Buchanan Daniel , Wormald Samuel , O'Connor Liam , Wilding Jennifer L. , Bicknell David , Tomlinson Ian P.M. , Bodmer Walter F. , Mariadason John M. , Sieber Oliver M.
Published: March 2023

XLSX file - 12KB, Comparison of POLE mutation spectra between 9 NSHP and 15 non-NSHP CRC cell lines and TCGA-analyzed primary cancers.
Supplementary Table S1 from PAK1 Tyrosine Phosphorylation Is Required to Induce Epithelial–Mesenchymal Transition and Radioresistance in Lung Cancer Cells
Authors: Kim EunGi , Youn HyeSook , Kwon TaeWoo , Son Beomseok , Kang JiHoon , Yang Hee Jung , Seong Ki Moon , Kim Wanyeon , Youn BuHyun
Published: March 2023

Primers for measuring the expression level of EMT-related genes.
Supplementary Methods and References from PAK1 Tyrosine Phosphorylation Is Required to Induce Epithelial–Mesenchymal Transition and Radioresistance in Lung Cancer Cells
Authors: Kim EunGi , Youn HyeSook , Kwon TaeWoo , Son Beomseok , Kang JiHoon , Yang Hee Jung , Seong Ki Moon , Kim Wanyeon , Youn BuHyun
Published: March 2023

Description of additional methods and procedures used in the study. Also includes supplementary references.
Data Supplement from Ubiquitin-like Protein FAT10 Promotes the Invasion and Metastasis of Hepatocellular Carcinoma by Modifying β-Catenin Degradation
Authors: Yuan Rongfa , Wang Kai , Hu Junwen , Yan Chen , Li Ming , Yu Xin , Liu Xiuxia , Lei Jun , Guo Wuhua , Wu Linquan , Hong Kui , Shao Jianghua
Published: March 2023

Supplementary Table S3. Association of various factors with invasion and metastasis determined by logistic regression.
Data Supplement from Ubiquitin-like Protein FAT10 Promotes the Invasion and Metastasis of Hepatocellular Carcinoma by Modifying β-Catenin Degradation
Authors: Yuan Rongfa , Wang Kai , Hu Junwen , Yan Chen , Li Ming , Yu Xin , Liu Xiuxia , Lei Jun , Guo Wuhua , Wu Linquan , Hong Kui , Shao Jianghua
Published: March 2023

Supplementary Figure S4. Knockdown of FAT10 inhibits HOXB9 expression through the β-catenin/TCF4 pathway in Huh-7 cells.
Supplementary Methods and References from STAT1 Drives Tumor Progression in Serous Papillary Endometrial Cancer
Authors: Kharma Budiman , Baba Tsukasa , Matsumura Noriomi , Kang Hyun Sook , Hamanishi Junzo , Murakami Ryusuke , McConechy Melissa M. , Leung Samuel , Yamaguchi Ken , Hosoe Yuko , Yoshioka Yumiko , Murphy Susan K. , Mandai Masaki , Hunstman David G. , Konishi Ikuo
Published: March 2023

Supplementary Methods and References. Description of additional methods and procedures used in the study. Also includes Supplementary References.
Supplementary Figure 1 from The TGFβ–miR200–MIG6 Pathway Orchestrates the EMT-Associated Kinase Switch That Induces Resistance to EGFR Inhibitors
Authors: Izumchenko Evgeny , Chang Xiaofei , Michailidi Christina , Kagohara Luciane , Ravi Rajani , Paz Keren , Brait Mariana , Hoque Mohammad O. , Ling Shizhang , Bedi Atul , Sidransky David
Published: March 2023

PDF file - 2120KB, FAK activity is significantly higher in erlotinib-resistant cells from lung and H and N origin. Total cell lysates were extracted from two pairs of lung (H358/H1703 and Calu3/Calu6) and two pairs of H and N (SCC-S/SCC-R and JHU011/JHU028) cancer cell lines and were subjected to immunoblot analysis with antibodies specific for phosphorylated and total FAK. Beta-actin was used a loading control.
Supplementary Figure S3 from STAT1 Drives Tumor Progression in Serous Papillary Endometrial Cancer
Authors: Kharma Budiman , Baba Tsukasa , Matsumura Noriomi , Kang Hyun Sook , Hamanishi Junzo , Murakami Ryusuke , McConechy Melissa M. , Leung Samuel , Yamaguchi Ken , Hosoe Yuko , Yoshioka Yumiko , Murphy Susan K. , Mandai Masaki , Hunstman David G. , Konishi Ikuo
Published: March 2023

Supplementary Figure S3. Activity of STAT1 pathway genes in endometrial cancer cells.
Supplementary Materials and Methods, Table 1, Figures 1 - 6 from SCP Phosphatases Suppress Renal Cell Carcinoma by Stabilizing PML and Inhibiting mTOR/HIF Signaling
Authors: Lin Yu-Ching , Lu Li-Ting , Chen Hsin-Yi , Duan Xueyan , Lin Xia , Feng Xin-Hua , Tang Ming-Jer , Chen Ruey-Hwa
Published: March 2023

Supplementary Materials and Methods: Description of additional methods used in this study. Supplementary References: List of references cited in Supplementary Materials and Methods. Supplementary Table 1: SCP1 expression in various tumors. Supplementary Figure 1. Screen for PMLS518 phosphatases. Supplementary Figure 2. The specificity of SCP1 antibody. Supplementary Figure 3. Representative IHC staining results for PML, pS518PML, SCP1, SCP3, and KLHL20. Supplementary Figure 4. The effects of combined inhibition of mTOR and PML degradation pathway in suppressing ccRCC. Supplementary Figure 5. The effects of combined treatment on tumor angiogenesis and mice body weight. Supplementary Figure 6. The effect of SCP1 on PML in PC-3 cells.
Supplementary Figure Legends from STAT1 Drives Tumor Progression in Serous Papillary Endometrial Cancer
Authors: Kharma Budiman , Baba Tsukasa , Matsumura Noriomi , Kang Hyun Sook , Hamanishi Junzo , Murakami Ryusuke , McConechy Melissa M. , Leung Samuel , Yamaguchi Ken , Hosoe Yuko , Yoshioka Yumiko , Murphy Susan K. , Mandai Masaki , Hunstman David G. , Konishi Ikuo
Published: March 2023

Supplementary Figure Legends. Legend for Supplementary Figures S1-S5.
Supplemental Information from Ag-Presenting CpG-Activated pDCs Prime Th17 Cells That Induce Tumor Regression
Authors: Guéry Leslie , Dubrot Juan , Lippens Carla , Brighouse Dale , Malinge Pauline , Irla Magali , Pot Caroline , Reith Walter , Waldburger Jean-Marc , Hugues Stéphanie
Published: March 2023

Supplemental Information. Supplemental Materials and Methods Supplemental Fig. 1 : Chimeric mice selectively lacking MHCII expression on pDCs. Supplemental Fig. 2 : Similar T cell proliferation in µMT:WT and µMT pIII+IV-/-:WT chimeric mice. Supplemental Fig. 3 : Selective MHCII abrogation on pDCs in μMT pIII+IV-/-:WT mice does not affect MHCII expression and upregulation in other cell subtypes. Supplemental Fig. 4 : MHCII deficient pDCs exhibit normal TLR responses in vitro. Supplemental Fig. 5 : Vaccination using OVA protein + CpG-B significantly inhibits tumor growth after Ag presentation by pDCs. Supplemental Fig. 6 : Characterisation of in vitro generated Th0 and Th17 OT-II T cells. Supplemental Fig. 7 : Impaired cell migration toward tumor supernatant in mice lacking MHCII on pDCs. Supplemental Fig. 8 : CD8+ T cell depletion in EG7 bearing mice.
Supplementary Table S3 from A Small-Molecule Modulator of the Tumor-Suppressor miR34a Inhibits the Growth of Hepatocellular Carcinoma
Authors: Xiao Zhangang , Li Chi Han , Chan Stephen L. , Xu Feiyue , Feng Lu , Wang Yan , Jiang Jian-Dong , Sung Joseph J.Y. , Cheng Christopher H.K. , Chen Yangchao
Published: March 2023

Supplementary Table S3. Growth inhibitory rates of Rubone on HepG2 xenografts.
Supplementary Methods, Figure Legends from Rapamycin Rescues ABT-737 Efficacy in Small Cell Lung Cancer
Authors: Gardner Eric E. , Connis Nick , Poirier John T. , Cope Leslie , Dobromilskaya Irina , Gallia Gary L. , Rudin Charles M. , Hann Christine L.
Published: March 2023

PDF file - 84KB
Supplementary Table S2 from A Small-Molecule Modulator of the Tumor-Suppressor miR34a Inhibits the Growth of Hepatocellular Carcinoma
Authors: Xiao Zhangang , Li Chi Han , Chan Stephen L. , Xu Feiyue , Feng Lu , Wang Yan , Jiang Jian-Dong , Sung Joseph J.Y. , Cheng Christopher H.K. , Chen Yangchao
Published: March 2023

Supplementary Table S2. The full library screening dataset.
Supplementary Figure 4 from Rapamycin Rescues ABT-737 Efficacy in Small Cell Lung Cancer
Authors: Gardner Eric E. , Connis Nick , Poirier John T. , Cope Leslie , Dobromilskaya Irina , Gallia Gary L. , Rudin Charles M. , Hann Christine L.
Published: March 2023

PDF file - 187KB, Supplemental Figure 4. Dose-dependent effects of rapamycin and ABT-737 on LX33 PDXs.
Supplementary Table S1 from A Small-Molecule Modulator of the Tumor-Suppressor miR34a Inhibits the Growth of Hepatocellular Carcinoma
Authors: Xiao Zhangang , Li Chi Han , Chan Stephen L. , Xu Feiyue , Feng Lu , Wang Yan , Jiang Jian-Dong , Sung Joseph J.Y. , Cheng Christopher H.K. , Chen Yangchao
Published: March 2023

Supplementary Table S1. Primer sequences used for qRT-PCR.
Supplementary Figure 3 from Rapamycin Rescues ABT-737 Efficacy in Small Cell Lung Cancer
Authors: Gardner Eric E. , Connis Nick , Poirier John T. , Cope Leslie , Dobromilskaya Irina , Gallia Gary L. , Rudin Charles M. , Hann Christine L.
Published: March 2023

PDF file - 399KB, Supplemental Figure 3. SCLC PDXs and cell lines express mTOR pathway components and the combination of ABT-737 and rapamycin is well tolerated in PDX-bearing mice.
Supplementary Materials and Methods from A Small-Molecule Modulator of the Tumor-Suppressor miR34a Inhibits the Growth of Hepatocellular Carcinoma
Authors: Xiao Zhangang , Li Chi Han , Chan Stephen L. , Xu Feiyue , Feng Lu , Wang Yan , Jiang Jian-Dong , Sung Joseph J.Y. , Cheng Christopher H.K. , Chen Yangchao
Published: March 2023

Supplementary Materials and Methods. Description of additional methods and procedures used in the study.
Supplementary Figures S1-S5 from A Small-Molecule Modulator of the Tumor-Suppressor miR34a Inhibits the Growth of Hepatocellular Carcinoma
Authors: Xiao Zhangang , Li Chi Han , Chan Stephen L. , Xu Feiyue , Feng Lu , Wang Yan , Jiang Jian-Dong , Sung Joseph J.Y. , Cheng Christopher H.K. , Chen Yangchao
Published: March 2023

Supplementary Figures S1-S5. The established miR-34a reporter was responsive to the endogeneous miR-34a level (S1); Rubone activated the expression of miR-34a (S2); Rubone inhibited Huh7 xenografted tumor growth (S3); Rubone activated pri-miR-34a expressions and inhibited angiogenesis in HepG2 xenografts (S4); Knockdown of p53 reversed pri-miR-34a expression and cell growth inhibition induced by Rubone in HepG2 and Bel-7404 cells (S5).
Supplementary Figure Legends from A Small-Molecule Modulator of the Tumor-Suppressor miR34a Inhibits the Growth of Hepatocellular Carcinoma
Authors: Xiao Zhangang , Li Chi Han , Chan Stephen L. , Xu Feiyue , Feng Lu , Wang Yan , Jiang Jian-Dong , Sung Joseph J.Y. , Cheng Christopher H.K. , Chen Yangchao
Published: March 2023

Supplementary Figure Legends. Legend for Supplementary Figures S1-S5.
Data Supplement from Definition of PKC-α, CDK6, and MET as Therapeutic Targets in Triple-Negative Breast Cancer
Authors: Hsu Yi-Hsin , Yao Jun , Chan Li-Chuan , Wu Ting-Jung , Hsu Jennifer L. , Fang Yueh-Fu , Wei Yongkun , Wu Yun , Huang Wen-Chien , Liu Chien-Liang , Chang Yuan-Ching , Wang Ming-Yang , Li Chia-Wei , Shen Jia , Chen Mei-Kuang , Sahin Aysegul A. , Sood Anil , Mills Gordon B. , Yu Dihua , Hortobagyi Gabriel N. , Hung Mien-Chie
Published: March 2023

Supplementary Figure S1. The mRNA expression of MAP4K5, TRIO, EPHA4, DGKA and MAPK7 in TNBC cells Supplementary Figure S2. Inhibition of PKC-alpha, MET, and CDK6 reduced stem cell-like population.
Supplementary Materials and Methods from PCTAIRE1 Phosphorylates p27 and Regulates Mitosis in Cancer Cells
Authors: Yanagi Teruki , Krajewska Maryla , Matsuzawa Shu-ichi , Reed John C.
Published: March 2023

Supplementary Materials and Methods. Primers for quantitative RT-PCR. In vitro kinase assays. Time-lapse microscopy. Patient specimens. Gene expression. Statistical Analysis.
Supplementary Figures and Tables from PCTAIRE1 Phosphorylates p27 and Regulates Mitosis in Cancer Cells
Authors: Yanagi Teruki , Krajewska Maryla , Matsuzawa Shu-ichi , Reed John C.
Published: March 2023

Supplementary Figures and Tables. Supplementary Fig. S1. Knockdown of PCTAIRE1 in PPC1 cells. Supplementary Fig. S2. Knockdown of PCTAIRE1 inhibits growth of Du145, MDA-MB-468 and HeLa cells. Supplementary Fig. S3. PCTAIRE1 regulates centrosome dynamics. Supplementary Fig. S4. PCTAIRE1 phosphorylates p27 at Ser10. Supplementary Fig. S5. PCTAIRE1 knockdown leads to accumulation of p27. Supplementary Fig. S6. Apoptosis induced by PCTAIRE1 knockdown, and subcellular localization of Eg5 in PCTAIRE1 knockdown cancer cells. Supplementary Fig. S7. Characterization of rabbit anti-PCTAIRE1 antibody and correlation of PCTAIRE1 and p27 expression. Supplementary Fig. S8. PCTAIRE1 expression is upregulated in cancers, and high PCTAIRE1 levels correlate with poor patient prognosis. Supplementary Table S1. Specific interaction of PCTAIRE1 with p27.
Supplemental Table S2 from H3K9 Histone Methyltransferase, KMT1E/SETDB1, Cooperates with the SMAD2/3 Pathway to Suppress Lung Cancer Metastasis
Authors: Wu Pei-Chun , Lu Jeng-Wei , Yang Jer-Yen , Lin I-Hsuan , Ou Da-Liang , Lin Yu-Hsiang , Chou Kuan-Hsien , Huang Wen-Feng , Wang Wan-Ping , Huang Yih-Leh , Hsu Chiun , Lin Liang-In , Lin Yueh-Min , Shen C.-K. James , Tzeng Tsai-Yu
Published: March 2023

Clinicopathological characteristics of patients with lung cancer.
Supplemental Figure S8 from H3K9 Histone Methyltransferase, KMT1E/SETDB1, Cooperates with the SMAD2/3 Pathway to Suppress Lung Cancer Metastasis
Authors: Wu Pei-Chun , Lu Jeng-Wei , Yang Jer-Yen , Lin I-Hsuan , Ou Da-Liang , Lin Yu-Hsiang , Chou Kuan-Hsien , Huang Wen-Feng , Wang Wan-Ping , Huang Yih-Leh , Hsu Chiun , Lin Liang-In , Lin Yueh-Min , Shen C.-K. James , Tzeng Tsai-Yu
Published: March 2023

ANXA2 is highly expressed in metastatic cancer cells.
Supplementary Methods and References from Targeting the c-Met/FZD8 Signaling Axis Eliminates Patient-Derived Cancer Stem–like Cells in Head and Neck Squamous Carcinomas
Authors: Sun Shuyang , Liu Suling , Duan Sheng Zhong , Zhang Lei , Zhou Henghua , Hu Yongjie , Zhou Xianghui , Shi Chaoji , Zhou Rong , Zhang Zhiyuan
Published: March 2023

Supplementary Methods and References. Description of additional methods and procedures used in the study. Also includes Supplementary References.
Supplemental Figure S6 from H3K9 Histone Methyltransferase, KMT1E/SETDB1, Cooperates with the SMAD2/3 Pathway to Suppress Lung Cancer Metastasis
Authors: Wu Pei-Chun , Lu Jeng-Wei , Yang Jer-Yen , Lin I-Hsuan , Ou Da-Liang , Lin Yu-Hsiang , Chou Kuan-Hsien , Huang Wen-Feng , Wang Wan-Ping , Huang Yih-Leh , Hsu Chiun , Lin Liang-In , Lin Yueh-Min , Shen C.-K. James , Tzeng Tsai-Yu
Published: March 2023

The KMT1E mutation (H1224A) does not suppress ANXA2 promoter activity in cancer cells.
Supplentary Figures 1-6 from DUSP1 Phosphatase Regulates the Proinflammatory Milieu in Head and Neck Squamous Cell Carcinoma
Authors: Zhang Xiaoyi , Hyer J. Madison , Yu Hong , D'Silva Nisha J. , Kirkwood Keith L.
Published: March 2023

Supplementary Figures 1-6 Supplemental Figure 1. Animals underwent weekly oral examinations after carcinogen withdrawal for the development of oral lesions. Supplemental Figure 2. Animals were monitored weekly for weight change as a surrogate measure for tumor burden Supplemental Figure 3. Macrophage polarization gene expression in tumor tissues by Nanostring Analysis. Supplemental Figure 4. Effect of DUSP1 expression on progression-free survival in breast Cancer. Supplemental Figure 5. Immunohistochemistry for phosphorylated forms of the MAPKs Supplemental Figure 6. Whole tumor lysates were assessed for phosphorylated and total forms of MAPKs
Supplementary Figure 3 from hMOB3 Modulates MST1 Apoptotic Signaling and Supports Tumor Growth in Glioblastoma Multiforme
Authors: Tang Fengyuan , Zhang Lei , Xue Gongda , Hynx Debby , Wang Yuhua , Cron Peter D. , Hundsrucker Christian , Hergovich Alexander , Frank Stephan , Hemmings Brian A. , Schmitz-Rohmer Debora
Published: March 2023

PDF file - 280KB, Supplemental Figure 3. hMOB3 negatively regulates MST1 apoptotic cleavage.
Supplemental Figure Legends from Adenosine A2A Receptors Intrinsically Regulate CD8+ T Cells in the Tumor Microenvironment
Authors: Cekic Caglar , Linden Joel
Published: March 2023

Supplemental Figure legends
Supplementary Table S5 from GPx2 Suppression of H2O2 Stress Links the Formation of Differentiated Tumor Mass to Metastatic Capacity in Colorectal Cancer
Authors: Emmink Benjamin L. , Laoukili Jamila , Kipp Anna P. , Koster Jan , Govaert Klaas M. , Fatrai Szabolcs , Verheem Andre , Steller Ernst J.A. , Brigelius-Flohé Regina , Jimenez Connie R. , Borel Rinkes Inne H.M. , Kranenburg Onno
Published: March 2023

Supplementary Table S5. Primer pairs used for RT-qPCR analysis.
Supplementary Figure 4. Multivariate analysis of the association of CERK expression and relapse-free survival after adjusting for subsets from Ceramide Kinase Promotes Tumor Cell Survival and Mammary Tumor Recurrence
Authors: Payne Ania W. , Pant Dhruv K. , Pan Tien-Chi , Chodosh Lewis A.
Published: March 2023

Forest plot representation of 5-year survival estimates and hazard ratios after adjusting for the impact of: (A) ER status, (B) PR status, (C) HER2 status, (D) molecular subtype and (E) tumor grade. Multivariate analysis was performed to assess the hazard ratio (HR) in individual datasets. Overall p-value and HR were calculated by meta-analysis.
Supplementary Figure S1 from GPx2 Suppression of H2O2 Stress Links the Formation of Differentiated Tumor Mass to Metastatic Capacity in Colorectal Cancer
Authors: Emmink Benjamin L. , Laoukili Jamila , Kipp Anna P. , Koster Jan , Govaert Klaas M. , Fatrai Szabolcs , Verheem Andre , Steller Ernst J.A. , Brigelius-Flohé Regina , Jimenez Connie R. , Borel Rinkes Inne H.M. , Kranenburg Onno
Published: March 2023

Supplementary Figure S1. Suppression of GPx2 reduces proliferation and clone forming potential of colon CSCs.
Supplementary Figure Legends from GPx2 Suppression of H2O2 Stress Links the Formation of Differentiated Tumor Mass to Metastatic Capacity in Colorectal Cancer
Authors: Emmink Benjamin L. , Laoukili Jamila , Kipp Anna P. , Koster Jan , Govaert Klaas M. , Fatrai Szabolcs , Verheem Andre , Steller Ernst J.A. , Brigelius-Flohé Regina , Jimenez Connie R. , Borel Rinkes Inne H.M. , Kranenburg Onno
Published: March 2023

Supplementary Figure Legends. Legends for Supplementary Figures S1-S6.
Supplementary Methods from Combined Genome and Transcriptome Analysis of Single Disseminated Cancer Cells from Bone Marrow of Prostate Cancer Patients Reveals Unexpected Transcriptomes
Authors: Gužvić Miodrag , Braun Bernhard , Ganzer Roman , Burger Maximilian , Nerlich Michael , Winkler Sebastian , Werner-Klein Melanie , Czyż Zbigniew T. , Polzer Bernhard , Klein Christoph A.
Published: March 2023

Supplementary Methods. Processing of BM samples, Staining of BM samples and cell lines, Screening of BM and isolation of single cells and cell pools, WTA, WGA, and Establishing of conditions for specific end-point PCR.
Supplementary Movie 2A from mTOR Signaling Feedback Modulates Mammary Epithelial Differentiation and Restrains Invasion Downstream of PTEN Loss
Authors: Ghosh Susmita , Varela Lidenys , Sood Akshay , Park Ben Ho , Lotan Tamara L.
Published: March 2023

MOV - 1727 KB, Acinar morphogenesis in parental MCF10A cells treated with rapamycin reveals absence of invasive protrusions into ECM. 54-hour time-lapse DIC imaging (roughly days 1-3 after plating) of parental MCF10A cells treated with rapamycin (200 nM). Invasive cytoplasmic protrusions into surrounding collagen-Matrigel ECM are absent.
Data Supplement from Uncontrolled Inflammation Induced by AEG-1 Promotes Gastric Cancer and Poor Prognosis
Authors: Li Guanghua , Wang Zhao , Ye Jinning , Zhang Xinhua , Wu Hui , Peng Jianjun , Song Wu , Chen Chuangqi , Cai Shirong , He Yulong , Xu Jianbo
Published: March 2023

Supplemental Table 2. The association between AEG-1 and TLR4 , SOCS1, p65 expression.
Supplemental Fig. 2 from Pancreatic Cancer–Specific Cell Death Induced In Vivo by Cytoplasmic-Delivered Polyinosine–Polycytidylic Acid
Authors: Bhoopathi Praveen , Quinn Bridget A. , Gui Qin , Shen Xue-Ning , Grossman Steven R. , Das Swadesh K. , Sarkar Devanand , Fisher Paul B. , Emdad Luni
Published: March 2023

Supplemental Fig. 2. Inhibition of autophagy by 3-MA or caspase-mediated-apoptosis by z-VAD rescues pancreatic cancer cells from [pIC]PEI-induced cell death
Supplementary Figure S1 from Proteolysis of EphA2 Converts It from a Tumor Suppressor to an Oncoprotein
Authors: Koshikawa Naohiko , Hoshino Daisuke , Taniguchi Hiroaki , Minegishi Tomoko , Tomari Taizo , Nam Sung-Ouk , Aoki Mikiko , Sueta Takayuki , Nakagawa Takashi , Miyamoto Shingo , Nabeshima Kazuki , Weaver Alissa M. , Seiki Motoharu
Published: March 2023

Supplementary Figure S1. Expression of EphA2 and MT1-MMP in human cancer cell lines.
Supplementary Figure S1 from Vacuolar-ATPase Inhibition Blocks Iron Metabolism to Mediate Therapeutic Effects in Breast Cancer
Authors: Schneider Lina S. , von Schwarzenberg Karin , Lehr Thorsten , Ulrich Melanie , Kubisch-Dohmen Rebekka , Liebl Johanna , Trauner Dirk , Menche Dirk , Vollmar Angelika M.
Published: March 2023

Supplementary Figure S1. Archazolid induces apoptosis in breast cancer cells in vitro.
Supplementary Figure 2 from TUBB3/βIII-Tubulin Acts through the PTEN/AKT Signaling Axis to Promote Tumorigenesis and Anoikis Resistance in Non–Small Cell Lung Cancer
Authors: McCarroll Joshua A. , Gan Pei Pei , Erlich Rafael B. , Liu Marjorie , Dwarte Tanya , Sagnella Sharon S. , Akerfeldt Mia C. , Yang Lu , Parker Amelia L. , Chang Melissa H. , Shum Michael S. , Byrne Frances L. , Kavallaris Maria
Published: March 2023

Purity of nuclear and cytoplasmic fractions isolated from ÃŽÂ²III-tubulin shRNA and control shRNA NSCLC cells.
Supplementary Figure 1 from TUBB3/βIII-Tubulin Acts through the PTEN/AKT Signaling Axis to Promote Tumorigenesis and Anoikis Resistance in Non–Small Cell Lung Cancer
Authors: McCarroll Joshua A. , Gan Pei Pei , Erlich Rafael B. , Liu Marjorie , Dwarte Tanya , Sagnella Sharon S. , Akerfeldt Mia C. , Yang Lu , Parker Amelia L. , Chang Melissa H. , Shum Michael S. , Byrne Frances L. , Kavallaris Maria
Published: March 2023

2D-DIGE experimental design.
Supplemental Figures S1-S7 from Enhanced Chemokine Receptor Recycling and Impaired S1P1 Expression Promote Leukemic Cell Infiltration of Lymph Nodes in Chronic Lymphocytic Leukemia
Authors: Patrussi Laura , Capitani Nagaja , Martini Veronica , Pizzi Marco , Trimarco Valentina , Frezzato Federica , Marino Filippo , Semenzato Gianpietro , Trentin Livio , Baldari Cosima T.
Published: March 2023

Comparison of surface labeling of CXCR4/CCR7 in unfixed or fixed cells (S1); CXCL12/CCL21 do not interfere with binding of the anti-CXCR4/CCR7 antibodies used in this study (S2); Co-localization analysis of internalized CXCR4 and CCR7 with Rab11 and Rab7 in normal and CLL B cells following antibody-mediated downregulation (S3); The imbalance between the plasma membrane and endosomal CXCR4/CCR7 pools in CLL cells can be normalized by targeting the microtubule cytoskeleton (S4); B-cell treatment with CXCL12 or CCL21 results in an increase in the surface levels of the respective receptors (S5); Enhanced adhesion to fibronectin of CXCL12- or CCL21-treated CLL cells compared to normal B cells (S6); CCR7 and S1P1 expression in B-CLL bone marrow biopsy samples (S7).
Supplementary Table S3 from Metastatic Competence Can Emerge with Selection of Preexisting Oncogenic Alleles without a Need of New Mutations
Authors: Jacob Leni S. , Vanharanta Sakari , Obenauf Anna C. , Pirun Mono , Viale Agnes , Socci Nicholas D. , Massagué Joan
Published: March 2023

Supplementary Table S3. Identification of known mutations.
Supplementary Table S4 from Discovery and Validation of Biomarkers That Distinguish Mucinous and Nonmucinous Pancreatic Cysts
Authors: Park Jisook , Yun Hwan Sic , Lee Kwang Hyuck , Lee Kyu Taek , Lee Jong Kyun , Lee Soo-Youn
Published: March 2023

Overall diagnostic performance of the protein markers identified for the differential diagnosis of pancreatic cysts.
Supplementary Figure S4 from Metastatic Competence Can Emerge with Selection of Preexisting Oncogenic Alleles without a Need of New Mutations
Authors: Jacob Leni S. , Vanharanta Sakari , Obenauf Anna C. , Pirun Mono , Viale Agnes , Socci Nicholas D. , Massagué Joan
Published: March 2023

Supplementary Figure S4. Cancer associated genes affected by copy number variations.
Supplementary Figure S3 from Metastatic Competence Can Emerge with Selection of Preexisting Oncogenic Alleles without a Need of New Mutations
Authors: Jacob Leni S. , Vanharanta Sakari , Obenauf Anna C. , Pirun Mono , Viale Agnes , Socci Nicholas D. , Massagué Joan
Published: March 2023

Supplementary Figure S3. Pairwise comparisons of allele frequencies between independently derived metastatic populations.
Supplemental Figures 1 - 2 from Grade-Dependent Metabolic Reprogramming in Kidney Cancer Revealed by Combined Proteomics and Metabolomics Analysis
Authors: Wettersten Hiromi I. , Hakimi A. Ari , Morin Dexter , Bianchi Cristina , Johnstone Megan E. , Donohoe Dallas R. , Trott Josephine F. , Aboud Omran Abu , Stirdivant Steven , Neri Bruce , Wolfert Robert , Stewart Benjamin , Perego Roberto , Hsieh James J. , Weiss Robert H.
Published: March 2023

1. Cytosolic lipid storage is decreased in RCC tissue with increasing tumor grade 2. Glutamine depletion attenuates RCC cell viability, decreases the anti-oxidant system, and results in evidence of increased oxidative stress
Supplementary Figures S1 through S6 and Supplementary Tables S1 and S2 from The PKC/NF-κB Signaling Pathway Induces APOBEC3B Expression in Multiple Human Cancers
Authors: Leonard Brandon , McCann Jennifer L. , Starrett Gabriel J. , Kosyakovsky Leah , Luengas Elizabeth M. , Molan Amy M. , Burns Michael B. , McDougle Rebecca M. , Parker Peter J. , Brown William L. , Harris Reuben S.
Published: March 2023

Table S1. Cell Line Information. Table S2. ChIP reagents. Figure S1. APOBEC3B upregulation by PMA in multiple cell lines. Figure S2. APOBEC3 mRNA levels in PMA-treated MCF10A. Figure S3. Extended timecourse for PMA induction of APOBEC3B. Figure S4. Viability controls for MCF10A cells treated with small molecule inhibitors. Figure S5. Expanded ChIP data for MCF10A cells treated with PMA alone or in combination with AEB071. Figure S6. Viability controls for cancer cell lines treated with AEB071.
Supplemental Figure S7 from Syntheses and Discovery of a Novel Class of Cinnamic Hydroxamates as Histone Deacetylase Inhibitors by Multimodality Molecular Imaging in Living Subjects
Authors: Chan C.T. , Qi J. , Smith W. , Paranol R. , Mazitschek R. , West N. , Reeves R. , Chiosis G. , Schreiber S.L. , Bradner J.E. , Paulmurugan R. , Gambhir S.S.
Published: March 2023

Supplemental Figure S7. Inhibition of UKE-1 cell proliferation by the lead HDAC inhibitor 1A12 alone and in combination with the Doxorubicin and Hsp90 inhibitor PU-H71.
Supplemental Figure Legends from Syntheses and Discovery of a Novel Class of Cinnamic Hydroxamates as Histone Deacetylase Inhibitors by Multimodality Molecular Imaging in Living Subjects
Authors: Chan C.T. , Qi J. , Smith W. , Paranol R. , Mazitschek R. , West N. , Reeves R. , Chiosis G. , Schreiber S.L. , Bradner J.E. , Paulmurugan R. , Gambhir S.S.
Published: March 2023

Legends for Supplemental Figures S1-S8.
Supplemental Figure Legends from The Estrogen Receptor Cofactor SPEN Functions as a Tumor Suppressor and Candidate Biomarker of Drug Responsiveness in Hormone-Dependent Breast Cancers
Authors: Légaré Stéphanie , Cavallone Luca , Mamo Aline , Chabot Catherine , Sirois Isabelle , Magliocco Anthony , Klimowicz Alexander , Tonin Patricia N. , Buchanan Marguerite , Keilty Dana , Hassan Saima , Laperrière David , Mader Sylvie , Aleynikova Olga , Basik Mark
Published: March 2023

Legends for Supplemental Figures S1-S8.
Supplementary Figure 7 from CASC15-S Is a Tumor Suppressor lncRNA at the 6p22 Neuroblastoma Susceptibility Locus
Authors: Russell Mike R. , Penikis Annalise , Oldridge Derek A. , Alvarez-Dominguez Juan R. , McDaniel Lee , Diamond Maura , Padovan Olivia , Raman Pichai , Li Yimei , Wei Jun S. , Zhang Shile , Gnanchandran Janahan , Seeger Robert , Asgharzadeh Shahab , Khan Javed , Diskin Sharon J. , Maris John M. , Cole Kristina A.
Published: March 2023

Depletion of the long isoform of CASC15 does not impact neuroblastoma cell viability.
Supplementary Figure 4 from CASC15-S Is a Tumor Suppressor lncRNA at the 6p22 Neuroblastoma Susceptibility Locus
Authors: Russell Mike R. , Penikis Annalise , Oldridge Derek A. , Alvarez-Dominguez Juan R. , McDaniel Lee , Diamond Maura , Padovan Olivia , Raman Pichai , Li Yimei , Wei Jun S. , Zhang Shile , Gnanchandran Janahan , Seeger Robert , Asgharzadeh Shahab , Khan Javed , Diskin Sharon J. , Maris John M. , Cole Kristina A.
Published: March 2023

rs6939340 genotype and expression of 6p22.3 gene products.
Supplementary Data: Figures and Tables Legend from PAD2 Overexpression in Transgenic Mice Promotes Spontaneous Skin Neoplasia
Authors: McElwee John L. , Mohanan Sunish , Horibata Sachi , Sams Kelly L. , Anguish Lynne J. , McLean Dalton , Cvitaš Iva , Wakshlag Joseph J. , Coonrod Scott A.
Published: March 2023

Supplementary Data: Figures and Tables Legend
Supplementary Fig 6 from Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance
Authors: Gurden Mark D. , Westwood Isaac M. , Faisal Amir , Naud Sébastien , Cheung Kwai-Ming J. , McAndrew Craig , Wood Amy , Schmitt Jessica , Boxall Kathy , Mak Grace , Workman Paul , Burke Rosemary , Hoelder Swen , Blagg Julian , Van Montfort Rob L.M. , Linardopoulos Spiros
Published: March 2023

ddPCR analysis of drug-resistance mutations shows they are pre-existing in cancer cell lines and quickly introduced into a population of HCT116 cells.
Supplementary Fig 3 from Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance
Authors: Gurden Mark D. , Westwood Isaac M. , Faisal Amir , Naud Sébastien , Cheung Kwai-Ming J. , McAndrew Craig , Wood Amy , Schmitt Jessica , Boxall Kathy , Mak Grace , Workman Paul , Burke Rosemary , Hoelder Swen , Blagg Julian , Van Montfort Rob L.M. , Linardopoulos Spiros
Published: March 2023

CCT251455 kills cancer cells by inhibiting the kinetochore recruitment of SAC protein.
Supplementary Figure Legends from Curcumin Promotes Autophagic Survival of a Subset of Colon Cancer Stem Cells, Which Are Ablated by DCLK1-siRNA
Authors: Kantara Carla , O'Connell Malaney , Sarkar Shubhashish , Moya Stephanie , Ullrich Robert , Singh Pomila
Published: March 2023

PDF file - 108KB
Supplementary Table S1 from Tenascin-C Protects Cancer Stem–like Cells from Immune Surveillance by Arresting T-cell Activation
Authors: Jachetti Elena , Caputo Sara , Mazzoleni Stefania , Brambillasca Chiara Svetlana , Parigi Sara Martina , Grioni Matteo , Piras Ignazio Stefano , Restuccia Umberto , Calcinotto Arianna , Freschi Massimo , Bachi Angela , Galli Rossella , Bellone Matteo
Published: March 2023

Supplementary Table S1. Proteins identified and quantified in the SILAC experiment, comparing T cells inhibited by TPIN-SCs (CD62Lhi) with those activated by TNE-SCs (CD62Llo) or with the subset activated by TPIN-SCs (CD62Llo).
Supplementary Methods and Reference from Androgen-Induced TMPRSS2 Activates Matriptase and Promotes Extracellular Matrix Degradation, Prostate Cancer Cell Invasion, Tumor Growth, and Metastasis
Authors: Ko Chun-Jung , Huang Cheng-Chung , Lin Hsin-Ying , Juan Chun-Pai , Lan Shao-Wei , Shyu Hsin-Yi , Wu Shang-Ru , Hsiao Pei-Wen , Huang Hsiang-Po , Shun Chia-Tung , Lee Ming-Shyue
Published: March 2023

Supplementary Methods and Reference. Description of additional methods and procedures used in the study. Also includes Supplementary Reference.
Supplemental Movie 4 from Full-Length Semaphorin-3C Is an Inhibitor of Tumor Lymphangiogenesis and Metastasis
Authors: Mumblat Yelena , Kessler Ofra , Ilan Neta , Neufeld Gera
Published: March 2023

Supplemental Movie 4. A time lapse movie showing the effect FR-Sema3C on the proliferation of lymphatic endothelial cells (LEC).
Supplemental Movie 2 from Full-Length Semaphorin-3C Is an Inhibitor of Tumor Lymphangiogenesis and Metastasis
Authors: Mumblat Yelena , Kessler Ofra , Ilan Neta , Neufeld Gera
Published: March 2023

Supplemental Movie 2. A time lapse movie showing the effect FR-Sema3C on the proliferation of human umbilical vein derived endothelial cells (HUVEC).
Supplementary Tables S1-S7 from Cytosolic TMEM88 Promotes Invasion and Metastasis in Lung Cancer Cells by Binding DVLS
Authors: Zhang Xiupeng , Yu Xinmiao , Jiang Guiyang , Miao Yuan , Wang Liang , Zhang Yong , Liu Yang , Fan Chuifeng , Lin Xuyong , Dong Qianze , Han Qiang , Zhao Huanyu , Han Yong , Han Xu , Rong Xuezhu , Ding Shuting , Wang Endi , Wang Enhua
Published: March 2023

Supplementary Tables S1-S7: Supplementary TableS1: Clinicopathological features of 40 paired fresh non-small cell lung cancer (NSCLC) samples Supplementary TableS2: Target sequences for siRNA and shRNA Supplementary TableS3: Primers for real-time RT-PCR Supplementary TableS4: Correlation of TMEM88 overexpression and clinicopathological features in 214 cases of non-small cell lung cancer (NSCLC) Supplementary TableS5: Summary of Cox univariate and multivariate regression analysis of the association between clinicopathological features and overall survival in 61 cases of non-small cell lung cancer (NSCLC) Supplementary TableS6: Expression of TMEM88 in various epithelial malignancies Supplementary TableS7: Correlation of cytosolic TMEM88 with the expression of p-P38 and Snail in 50 NSCLC specimens
Supplementary Figures S1-S9 from Cytosolic TMEM88 Promotes Invasion and Metastasis in Lung Cancer Cells by Binding DVLS
Authors: Zhang Xiupeng , Yu Xinmiao , Jiang Guiyang , Miao Yuan , Wang Liang , Zhang Yong , Liu Yang , Fan Chuifeng , Lin Xuyong , Dong Qianze , Han Qiang , Zhao Huanyu , Han Yong , Han Xu , Rong Xuezhu , Ding Shuting , Wang Endi , Wang Enhua
Published: March 2023

Supplementary Figures S1-S9: Supplementary FigureS1: Expression and localization of TMEM88 in epithelial malignancies and non-small cell lung cancer (NSCLC) cell lines Supplementary FigureS2: Effect of TMEM88 on canonical Wnt signaling and expression of its downstream target genes Supplementary FigureS3: Co-localization of and interaction between TMEM88 and DVLS in different cellular compartments Supplementary FigureS4: Effects of TMEM88 on proliferation, migration, and invasion of NSCLC cells with cytosolic TMEM88 Supplementary FigureS5: Effects of TMEM88 on proliferation and invasion of non-small cell lung cancer cells Supplementary FigureS6: Effects of cytosolic TMEM88 on expression of epithelial-mesenchymal transition (EMT) proteins Supplementary FigureS7: Effect of TMEM88 and DVLS co-transfection on expression of Snail and invasion in NSCLC cells Supplementary FigureS8: Effects of co-transfecting TMEM88 and DVLS on proteins involved in Snail stabilization Supplementary FigureS9: Overexpression of TMEM88 did not influence expression of Snail, occludin, or ZO-1 in cells with membrane-bound TMEM88
Supplementary Figure 3 from STAT3 Blockade Inhibits Radiation-Induced Malignant Progression in Glioma
Authors: Lau Jasmine , Ilkhanizadeh Shirin , Wang Susan , Miroshnikova Yekaterina A. , Salvatierra Nicolas A. , Wong Robyn A. , Schmidt Christin , Weaver Valerie M. , Weiss William A. , Persson Anders I.
Published: March 2023

Figure S3: IR induces a sustained cell-intrinsic mesenchymal transition in HGG cell cultures.
Supplementary Figure S1 from Carbonic Anhydrase Activity Monitored In Vivo by Hyperpolarized 13C-Magnetic Resonance Spectroscopy Demonstrates Its Importance for pH Regulation in Tumors
Authors: Gallagher Ferdia A. , Sladen Helen , Kettunen Mikko I. , Serrao Eva M. , Rodrigues Tiago B. , Wright Alan , Gill Andrew B. , McGuire Sarah , Booth Thomas C. , Boren Joan , McIntyre Alan , Miller Jodi L. , Lee Shen-Han , Honess Davina , Day Sam E. , Hu De-En , Howat William J. , Harris Adrian L. , Brindle Kevin M.
Published: March 2023

Supplementary Figure S1. Representative 31P-MRS spectra of EV5 and CA9/1 tumors.
Supplementary Methods from A Systematic Approach to Defining the microRNA Landscape in Metastasis
Authors: Mudduluru Giridhar , Abba Mohammed , Batliner Jasmin , Patil Nitin , Scharp Maike , Lunavat Taral R. , Leupold Jörg Hendrik , Oleksiuk Olga , Juraeva Dilafruz , Thiele Wilko , Rothley Melanie , Benner Axel , Ben-Neriah Yinon , Sleeman Jonathan , Allgayer Heike
Published: March 2023

Supplementary Methods. Description of additional methods and procedures used in the study.
Supplementary Figure S5 from A Systematic Approach to Defining the microRNA Landscape in Metastasis
Authors: Mudduluru Giridhar , Abba Mohammed , Batliner Jasmin , Patil Nitin , Scharp Maike , Lunavat Taral R. , Leupold Jörg Hendrik , Oleksiuk Olga , Juraeva Dilafruz , Thiele Wilko , Rothley Melanie , Benner Axel , Ben-Neriah Yinon , Sleeman Jonathan , Allgayer Heike
Published: March 2023

Supplementary Figure S5. FOXN3 significantly enhances survival in a small cohort of TCGA colorectal cancer samples.
Supplementary Figure S1 from α-Tubulin Acetylation Elevated in Metastatic and Basal-like Breast Cancer Cells Promotes Microtentacle Formation, Adhesion, and Invasive Migration
Authors: Boggs Amanda E. , Vitolo Michele I. , Whipple Rebecca A. , Charpentier Monica S. , Goloubeva Olga G. , Ioffe Olga B. , Tuttle Kimberly C. , Slovic Jana , Lu Yiling , Mills Gordon B. , Martin Stuart S.
Published: March 2023

Supplementary Figure S1. Detyrosinated α-tubulin is not elevated in metastatic breast tumor cell lines, while acetylated α-tubulin is maintained under suspended conditions and correlates with more numerous McTNs in metastatic breast cancer cells.
Supplementary Table SII from Hyperthermia Selectively Targets Human Papillomavirus in Cervical Tumors via p53-Dependent Apoptosis
Authors: Oei Arlene L. , van Leeuwen Caspar M. , ten Cate Rosemarie , Rodermond Hans M. , Buist Marrije R. , Stalpers Lukas J.A. , Crezee Johannes , Kok H. Petra , Medema Jan Paul , Franken Nicolaas A.P.
Published: March 2023

Cell cycle distribution of control cultures and after the different treatments of HPV negative cell lines.
Supplementary Table SI from Hyperthermia Selectively Targets Human Papillomavirus in Cervical Tumors via p53-Dependent Apoptosis
Authors: Oei Arlene L. , van Leeuwen Caspar M. , ten Cate Rosemarie , Rodermond Hans M. , Buist Marrije R. , Stalpers Lukas J.A. , Crezee Johannes , Kok H. Petra , Medema Jan Paul , Franken Nicolaas A.P.
Published: March 2023

Cell cycle distribution of control cultures and after the different treatments of HPV positive cell lines.
Supplementary Figure S4 from Hyperthermia Selectively Targets Human Papillomavirus in Cervical Tumors via p53-Dependent Apoptosis
Authors: Oei Arlene L. , van Leeuwen Caspar M. , ten Cate Rosemarie , Rodermond Hans M. , Buist Marrije R. , Stalpers Lukas J.A. , Crezee Johannes , Kok H. Petra , Medema Jan Paul , Franken Nicolaas A.P.
Published: March 2023

Induction of apoptosis determined using Nicoletti assay in HPV-positive and HPV-negative cells after radiation, hyperthermia and combined treatment in the presence or absence of P53-siRNA,cDDP, chloroquine or MG-132.