bluuebunny/crossref_metadata_2025 huggingface dataset:
Polypharmacy in primary care: A population-based retrospective cohort study of electronic health records
Authors: Woodcock Thomas , Lovett Derryn , Ihenetu Gloria , Novov Vesselin , Beaney Thomas , Armani Keivan , Quilley Angela , Majeed Azeem , Aylin Paul
Published: September 2024

Background

Polypharmacy, prescription of multiple medications to a patient, is a major challenge for health systems. There have been no peer-reviewed studies of polypharmacy prevalence and medication cost at a population level in England.

Aims

To determine prevalence and medication cost of polypharmacy, by patient characteristics.

Design and setting: Retrospective cohort study of North West London electronic health records

Method

We quantified prevalence and direct cost of polypharmacy (five or more regular medications), stratified by demographics and frailty. We fitted a mixed-effects logistic regression for polypharmacy.

Results

Of 1.7 million adults, 167,665 (9.4%) were on polypharmacy. Age and socio-economic deprivation were associated with polypharmacy (OR 9.24 95% CI 8.99 to 9.50, age 65–74 compared with 18–44; OR 0.68 95% CI 0.65 to 0.71, least deprived compared with most). Polypharmacy prevalence increased with frailty (OR 1.53 95% CI 1.53 to 1.54 per frailty component, for White women). Men had higher odds of polypharmacy than women at average frailty (OR 1.26 95% CI 1.24 to 1.28) and with additional frailty components (OR 1.10 95% CI 1.09 to 1.10). Black people had lower odds of polypharmacy at average frailty (OR 0.82 95% CI 0.79 to 0.85, compared with White), but along with other ethnicities, saw greater odds increases with increasing frailty (OR 1.02 95% CI 1.01 to 1.03). Annual medication cost 8.2 times more for those on polypharmacy compared with not (£370.89 and £45.31).

Conclusion

Demographic characteristics are associated with polypharmacy, after adjusting for frailty. Further research should explore why, to reduce health inequities and optimise cost associated with polypharmacy.
Pocket warming of bupivacaine with fentanyl to shorten onset of labor epidural analgesia: A double-blind randomized controlled clinical trial
Authors: Balon Tyler M. , Xia Yun , McKeown Johnny , Wang Jack , Abbott Justin J. , Palettas Marilly , Uribe Alberto , Echeverria Villalobos Marco , Coffman John C. , Hu Ling-Qun
Published: September 2024

Shortening analgesic onset has been researched and it has been documented that prewarming epidural medications to body temperature (37°C) prior to administration increases medication efficacy. Our double-blind randomized controlled trial was designed to investigate if a lower degree of prewarming in providers’ pockets could achieve similar results without the need of a bedside incubator. A total of 136 parturients were randomized into either the pocket-warmed group or the room temperature group to receive 10 mL of 0.125% bupivacaine with 2 μg/mL fentanyl epidural bolus at either the 27.8 ±1.7°C or 22.1 ±1.0°C temperatures, respectively. Primary outcome, time to analgesic onset (verbal rating scale pain score ≤ 3) was recorded in 0-, 5-, 10-, 15-, 20-, 30-, and 60-minutes intervals. It was observed that the pocket-warming group (n = 64) and room temperature group (n = 72) had no significant difference of analgesic onset time (median 8 vs. 6.2 minutes; p = 0.322). The incidence of adverse events such as hypotension, fever (≥ 38°C), nausea, vomiting, and number of top-off epidural boluses, as well as patient satisfaction rates and mode of delivery, were not significantly different between the groups as well. Further research is warranted to confirm these findings and explore the impact of different temperatures on analgesic onset time as well as the logistical issues associated with their clinical implementations.
Prediction of infectious diseases using sentiment analysis on social media data
Authors: Song Youngchul , Yoon Byungun
Published: September 2024

As the influence and risk of infectious diseases increase, efforts are being made to predict the number of confirmed infectious disease patients, but research involving the qualitative opinions of social media users is scarce. However, social data can change the psychology and behaviors of crowds through information dissemination, which can affect the spread of infectious diseases. Existing studies have used the number of confirmed cases and spatial data to predict the number of confirmed cases of infectious diseases. However, studies using opinions from social data that affect changes in human behavior in relation to the spread of infectious diseases are inadequate. Therefore, herein, we propose a new approach for sentiment analysis of social data by using opinion mining and to predict the number of confirmed cases of infectious diseases by using machine learning techniques. To build a sentiment dictionary specialized for predicting infectious diseases, we used Word2Vec to expand the existing sentiment dictionary and calculate the daily sentiment polarity by dividing it into positive and negative polarities from collected social data. Thereafter, we developed an algorithm to predict the number of confirmed infectious patients by using both positive and negative polarities with DNN, LSTM and GRU. The method proposed herein showed that the prediction results of the number of confirmed cases obtained using opinion mining were 1.12% and 3% better than those obtained without using opinion mining in LSTM and GRU model, and it is expected that social data will be used from a qualitative perspective for predicting the number of confirmed cases of infectious diseases.
Consumption patterns and factors associated with inappropriate prescribing of benzodiazepines in Primary Health Care settings
Authors: Barboza Zanetti Maria Olívia , dos Santos Iara , Durante Júlia Casanova , Varallo Fabiana Rossi , Pereira Leonardo Régis Leira , Miasso Adriana Inocenti
Published: September 2024

Background

Benzodiazepines are frequently prescribed to treat anxiety and insomnia, but long-term use has been associated with the development of dependence, tolerance, and cognitive decline, especially among older adults. This study aimed to investigate the pattern of consumption and factors associated with inappropriate prescribing of benzodiazepines in primary health care.

Methods

This is a cross-sectional analytical study, using dispensing records of diazepam, clonazepam, and nitrazepam from public pharmacies in a Brazilian municipality between 2018 and 2022. Metrics for benzodiazepine consumption were DDD (Defined Daily Dose) and DDD/1000PD (per 1000 population per day). Long-term/prolonged benzodiazepine use was defined as consuming at least 90 DDD and at least 2 dispensations per year. To ascertain associations between long-term use and predictor variables, a multivariate logistic regression model was utilized.

Findings

A total of 40402 participants were included, with an average age of 55 years (SD = 0.30), 38.5% were older aged. Diazepam and nitrazepam exceeded the daily dose recommended. There was a reduction in diazepam consumption during the study period, as calculated by DDD/1.000PD, while the consumption of other benzodiazepines remained stable. However, a significant increase in diazepam consumption is noted when considering the last decade. Prolonged use was observed in 29.1% of participants, with a significant prevalence among the older people (34.8% of them were long-term users) and advancing age was identified as a risk factor for long-term use. Higher PDDs were also associated with long-term use and aging. Participants who used different benzodiazepines during the period had a higher risk of prolonged use.

Conclusions

These results provide insights into the prevalence of problematic utilization of benzodiazepines in primary health care. Authorities and health care providers must take steps to encourage gradual cessation of prolonged benzodiazepine prescriptions and the embrace of suitable strategies for addressing anxiety and insomnia within primary health care settings.
Kanonikus és aktuális
Authors: Székelyné Nagy Zsuzsanna , Fenyő D. György
Published: September 2024

Tanulmányunk Závada Pál Apfelbaum című verses regényének iskolai feldolgozásához ad különféle szempontokat és feladatokat. Az elbeszélő költeményt mint történelmi tablót tekintjük egyik feladatunkban, mint a verses regény műfajának egy változatát egy másikban, mint Madách Imre Az ember tragédiája című színművének parafrázisát egy harmadikban, mint filozófiai-történetfilozófiai kérdéseket exponáló művet egy negyedikben, és mint az ember társadalmi cselekvési lehetőségeit vizsgáló alkotást egy következőben. A tanulmány pedagógiai felfogását tekintve a konstruktív pedagógia talaján áll, módszertanilag a kooperatív és felfedeztető eljárásokat részesíti előnyben, az olvasóvá nevelés útjai közül a részletek tanításának elvét tartja hatékonynak, a tanítás céljának pedig a diákok szembesítését tartja lényegi – egzisztenciális, morális és történelmi – kérdésekkel.
Una de cal y otra de arena
Authors: Ongay de Felipe Íñigo , Loredo José Carlos
Published: September 2024

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Development of Renewable Energy Modules with Contextual Teaching Learning Helpful Augmented Reality (AR) Integrated Al-Qur’an Class X SMA/MA
Authors: Karlina Mella , Chandra A N , Imamora M , Idrus H
Published: September 2024

This research was motivated by the limited teaching materials used by educators in the learning process. The only teaching materials available are textbooks and handouts, but there are no learning modules yet. The research was conducted on renewable energy material for class X SMA/MA. Augmented Reality (AR) is needed for renewable energy materials to be able to change images into three dimensions. Research conducted at Madrasah Aliyah strongly supports modules that integrate verses from the Koran. Therefore, it is necessary to develop a Renewable Energy module with Contextual Teaching Learning assisted by Augmented Reality (AR) integrated with the Koran. The type of development research used is the 4-D model (Define, Design, Development, Dissemination). However, the development of this AR-based integrated physics learning module for Al-Qur'an verses only uses three stages, namely Define, Design, and Development. The instrument used in this research is the validation sheet. The research results show that the module developed is valid and very practical for use by educators and students in learning.
Development of Pop-Up Book Based Learning Media on Optical Instruments Material in Senior High School/Islamic Senior High School
Authors: Zahara Laxmi , Khadijah Siti Laili , Wajdi Badrul
Published: September 2024

Learning media makes the teaching and learning process easier and increases students' interest in learning. This development research developed a pop-up book-based learning media on optical devices material for Senior High School/Islamic Senior High School. This type of research is research and development research. The development model used in this research is the 4D model: define, design, develop, and disseminate. Product testing of pop-up book- based learning media development applied validation from material experts and media experts, subject teachers and student response questionnaires. Technical analysis of data from the distribution of questionnaires was done by tabulating data from each validator and calculating the percentage. Data collection techniques use instruments in the form of interviews, sheets validation, questionnaire, and pretest-posttest. The researchers analyzed the obtained data using the formula for determine the percentage of product feasibility. Based on the assessment results of 2 material experts, 2 media experts and 2 teachers, it shows that pop up books are included in the very feasible category. Meanwhile, the student response assessment was included in the very good response category and the results of the effectiveness test showed the quite effective category.
Coping Stress Pada Pelajar Kawruh Jiwa Lansia Duda Pasca Kematian Pasangan
Authors: Himawan Ronan , Prasetya Berta Esti Ari
Published: September 2024

Becoming a widower after the death of a spouse in the elderly is not an easy matter for men. The event of the death of a life partner is one of life's challenges that cause and increase stress in the elderly. Culture also influences the way individuals cope with stress. This study explores the perspective of individuals living within the wisdom of local culture, as adherents of kawruh jiwa spirituality. The research employs a qualitative phenomenological study method, involving two elderly spiritual adherents who are widowers following the death of their partners. Moustakas' phenomenological data analysis is utilized. The research findings reveal the existence of a spiritual concept of kawruh jiwa knowledge that is utilized as a stress coping strategy. Among these concepts are saiki kene ngene yo gelem, nyawang karep, bungah susah, and sabutuhe saperlune sacukupe sapenake samestine sabenere. This study's findings offer novelty in terms of thematic analysis using the concept of kawruh jiwa spirituality as a source of coping strategies for elderly widowers following the death of their partners. 
 
Menjadi duda pasca kematian pasangan pada lansia bukanlah perkara mudah bagi para pria. Peristiwa kematian pasangan hidup merupakan salah satu tantangan hidup yang mengakibatkan dan meningkatkan stres pada lansia. Kebudayaan juga turut memengaruhi cara individu tersebut dalam menghadapi stres. Dalam penelitian ini peneliti mengeksplorasisudut pandang dari individu yang hidup dalam kearifan budaya lokal, sebagai penghayat kawruh jiwa. Penelitian ini menggunakan metode penelitian studi kualitatif fenomenologi, dengan melibatkan dua orang penghayat kawruh jiwa lansia yang berstatus duda pasca kematian pasangan. Analisis data menggunakan analisis data fenomenologi Moustakas. Hasil penelitian menemukan bahwa terdapat konsep spiritual kawruh jiwa yang dimanfaatkan sebagaistrategi koping stres. Di antaranya adalah konsep saiki kene ngene yo gelem, nyawang karep, bungah susah, dan sabutuhe saperlune sacukupe sapenake samestine sabenere. Temuan studi ini menawarkan kebaharuan dari sisi analisis tema yang menggunakan konsep spiritual kawruh jiwa sebagai sumber strategi pemecahan masalah bagi lansia duda pasca kematian pasangan.
Mastering Digital Media Literacy of Muslim Woman's Activists in Preventing Online Gender-Based Violence
Authors: Prima Ayu Rizqy Mahanani  , Pratiwi Fatma Dian , Fartika Ifriqia  , Niken Puspita Sari
Published: September 2024

This article tends to analyze how Muslim women's activists, who are the members of Nasyiatul Aisyiyah and Fatayat NU in Kediri and Yogyakarta, build their digital literacy to prevent violence in social media. Mainly due to the digital divide between men and women, which causes imbalance and injustice when they access digital media. The method used in data collection was semi-ethnographic, in which the researcher participated in observing research objects when carrying out activities using digital technology, interviews, and documentation on 3 members of Nasyiatul Aisyiyah and Fatayat NU, both in Jogja and Kediri. The research findings show that what has been stigmatized to women so far is that they are powerless to master information and communication technology, which does not apply to members of Fatayat NU and Nasyiatul Aisyiyah. This research shows that women are also reliable in accessing the internet for the benefit of empowering women, especially KBGO issues. This research has provided a different understanding of the phenomenon of the massive use of internet-based technology by female activists
Scholars and Literati at the Stanislas Academy in Nancy (1750–1793)
Authors: De la Croix David , Kotala Clara
Published: September 2024

This note is a summary description of the set of scholars and literati at the Stanislas Academy in Nancy between its creation in 1750 and its dissolution in 1793. For more detailed information about these individuals, please visit the comprehensive database available at https://shiny-lidam.sipr.ucl.ac.be/scholars/.
Fratura panfacial: relato de caso
Authors: Massote Pestana Ana Paula , Martins Pereira Rossafa Virgínia , Furtado de Carvalho Matheus
Published: September 2024

Introdução: As fraturas panfacias apresentam particularidades que exigem maior atenção e dedicação dos profissionais que realizam o atendimento primário e secundário das vítimas. Um dos principais desafios é o correto diagnóstico de todas as fraturas, principalmente aquelas que acometem o terço médio da face. Para tanto, recomenda-se, sempre que possível, a solicitação de tomografias computadorizadas no pré-operatório. Relato de caso: Paciente do sexo masculino, vítima de acidente motociclístico, submetido a procedimento cirúrgico, sob anestesia geral, por meio de...
Avaliação da saúde sinusal após tratamento das fraturas da parede anterior do seio frontal: série de casos
Authors: Ferreira de Almeida Neto Luis , Pires Marcelino Karolina , Louise Gomes do Rosário Alves da Mota Nathalia , Fontes Silva da Cunha Lima Luciana , Ranier Maciel Dantas Wagner , Rocha Germano Adriano
Published: September 2024

Objetivo: Objetivou-se avaliar possíveis complicações pós-operatórias e verificar alterações anatômicas do seio frontal, por meio da análise clínica e tomográfica, em uma série de casos de pacientes que foram tratados com fraturas da parede anterior do seio frontal. Material e Métodos: Foram avaliados 10 pacientes com fratura da parede anterior do seio frontal que foram operados no Serviço de Residência em Cirurgia e Traumatologia Buco-Maxilo-Facial no Hospital Universitário Onofre Lopes da Universidade Federal do Rio Grande do Norte, com um pós-operatório mínimo de 6...
Correlation and regression studies of SPAD based leaf nitrogen estimation as impacted by nitrogen and zinc management under medium land rice in Alfisols of Odisha
Authors: Rath Sweta , Mohapatra Ashok Kumar , Dash Subhaprada
Published: September 2024

One of the most significant staple crops in the world is rice (Oryza sativa L.), its productivity largely depends on various factors, including nutrient management. In particular, nitrogen and zinc management play crucial roles in rice cultivation as they significantly impact the leaf nitrogen content, which is closely associated with plant growth, photosynthesis and ultimately grain yield. Field tests were conducted at the Agricultural Research Station, Chhatabara, SOA (Deemed to be University), Bhubaneswar, Odisha, India during the kharif of 2021 and 2022 to measure the effect of nitrogen and zinc management on the productivity of rice crop yield. Split plot design was employed in this experiment in 3 replications The findings of the experiment revealed that 125 % higher the recommended dose of nitrogen (RDN) gave significantly the highest pooled, periodic SPAD values, leaf nitrogen contents, grain (5700 kg/ha) and straw yield (6880 kg/ha) respectively. This was at par with the treatment where 75 % of the RDN was supplied through Urea and the rest 25 % through FYM. Among the zinc management practices, one soil application and 3 foliar sprays of zinc sulfate @ 2.5 kg/ha and 0.5 % respectively, at the stages of active tillering, heading and panicle initiation yielded significantly than the other treatments. The SPAD value and leaf nitrogen content showed a positive correlation with grain and straw yields in rice crops across different growth stages and years.
Moniuszko and Nowowiejski: analogies, contexts and inspirations
Authors: Dulisz Ilona
Published: September 2024

The music of Stanisław Moniuszko and Feliks Nowowiejski constitutes a crucial element in Polish musical culture. The two composers forged their image on work focussed on national ideas, particularly in their stage works and songs. An important factor shaping their attitudes was the multi-cultural society in which they were raised and their awareness of national identity. Also presented in this article are Nowowiejski’s attitude to Moniuszko’s music and his presence in the latter’s works.
Corrosion behavior of Cu–40Zn alloy in a periodic service between simulating atmospheric and deep sea environment
Authors: Hu Shengbo , Liu Zhong , Yuan Xuwen , Meng Fandi , Liao Luhai , Guo Rui , Yang Wei , Li Fengguang
Published: September 2024

The corrosion behavior of Cu–40Zn alloy in a periodic service between simulating atmospheric and deep sea environment has been systematically studied. Results showed that a layer of protective corrosion products can be formed quickly and become defective over time. During the periodic service, the HP (high hydrostatic pressure) promotes the anodic dissolution of the base and the generation of (Cu, Zn)2(OH)3Cl, which causes expansion of the corrosion products; the AP (alternating pressure) facilitates the wetting process during dry to wet stage, and the alternating force caused by AP leads to the cracks, peeling off of the corrosion products. Severe intergranular corrosion takes place, which initiates at the β phase and is accelerated by the combination of defective corrosion products and the drying stage.
Multifunctionality matters: preverbal yǒu in Mandarin and its aspectual potential
Authors: Sun Linlin , Bisang Walter
Published: September 2024

This article confronts a multifunctional grammaticalized form in Mandarin, the preverbal morpheme yǒu (有). Since its appearance in the Chinese mainland around the 1990s, there has been controversy about whether it is an aspect marker or not. In response to this question, we conducted a questionnaire survey to investigate how native Mandarin speakers generally understand sentences with preverbal yǒu. The results not only show that preverbal yǒu can serve as a perfective viewpoint marker that makes the terminal boundary of an event semantically visible, but also provide evidence of its other function as an existential marker. The concrete function of preverbal yǒu (perfective or existential) depends on pragmatic inference based on the temporal properties of a given situation. With this observation, the paper resolves the controversy of which of these two functions actually applies to preverbal yǒu, and integrates this marker into the broader context of pragmatics-based multifunctionality as it is widely found in Sinitic and mainland Southeast Asian languages.
Degradation of Pinus sylvestris and Populus tremula by laccate Ganoderma species
Authors: Cortina-Escribano Marta , Barbero-López Aitor , Kilpeläinen Petri , Vanhanen Henri , Haapala Antti
Published: September 2024

Wood chips and sawdust are used for cultivating Ganoderma lucidum mushrooms. In Northern Europe, side-streams of Pinus sylvestris are highly abundant, however as cultivation substrate they inhibit the growth of G. lucidum. To identify the changes in lignocellulosic composition after fungal degradation, the major lignocellulosic components in P. sylvestris and an optimal substrate for G. lucidum, Populus tremula were analyzed. Populus tremula was evenly degraded while the glucan fraction of P. sylvestris was not degraded and its lignin fraction was consumed almost completely. Despite not being an optimal substrate, P. sylvestris was successfully delignified by G. lucidum.
Strategic Location and Manager Delegation with Concentrated Consumer Demand
Authors: Stadler Manfred , Unsorg Maximiliane
Published: September 2024

This paper studies how the separation of ownership and management affects firms’ location decisions in a model of price competition with concentrated consumer demand. Strategic location decisions are made by the owners themselves, whereas operational price decisions are delegated to managers. It is shown that the impact of manager delegation on locations, prices and profits crucially depends on the shape of the demand distribution. When the distribution is “broad-peaked”, delegation leads to more distant locations, higher prices and profits. However, “narrow-peaked” distributions reverse the delegation effect on location and can even lead to lower prices and profits.
Römisch-katholische Perspektiven auf die Heilung der Erinnerungen mit den täuferischen Kirchen
Authors: Hammes Verena
Published: September 2024

Im Zugehen auf den 500. Jahrestag zur Erinnerung an die Glaubenstaufe in Zürich im Jahr 1525 sucht dieser Artikel nach Spuren von einer Heilung der Erinnerung zwischen römisch-katholischer und den täuferischen Kirchen in den internationalen und nationalen Dialogdokumenten. Er weist auf verpasste Chancen hin, nimmt eine Standortbestimmung im katholisch-täuferischen Dialog vor und fragt nach Perspektiven des ökumenischen Miteinanders in der Zukunft.
Everything Begins in the Middle
Authors: Dima Vlad
Published: September 2024

Xala is perhaps the film that best encapsulates Ousmane Sembene’s entire career. It also hints at the future of African cinemas and the next generations of African and/or African diasporic filmmakers. To pull at this thread, my reading of Xala goes through the prism of African futurity, as understood by Senegalese philosopher Felwine Sarr and others, and focuses on the final scene and on several female characters. Initially laser-focused on colonial and postcolonial tensions, African cinemas remained largely pessimistic in their developmental stages. While concerns with postcolonialism tinged with heavy doses of pessimism have somewhat remained the norm, a variety of more hopeful cinematic productions have appeared in the new century. In short, pessimism and optimism have been clashing in contemporary African films, much as they were in Xala’s final scene fifty years ago. What might this moment teach us about African futurity more specifically, though?
Migración a Direccionamiento IPv6 para un Campus Universitario
Authors: Gonzales Calienes Rossina Isabel , Bustamante Alvarez Rafael
Published: September 2024

En el presente artículo se propone un plan de transición del protocolo IPv4 al protocolo IPv6 para su implementación en un campus universitario. Se expone acerca de los factores y consideraciones para el despliegue del protocolo IPv6 que constituye un entorno que estimula la transición. Además, se presenta una simulación de un escenario de red donde se implementa el mecanismo de transición Dual Stack para realizar un análisis comparativo entre el protocolo IPv4 y el protocolo IPv6 con respecto a la latencia.
ІНСТИТУЦІЙНІ ІНСТРУМЕНТИ ЗАБЕЗПЕЧЕННЯ РЕЗИЛЬЄНТНОСТІ ПРИРОДНО-РЕСУРСНОГО КОМПЛЕКСУ: БЕЗПЕКОВИЙ АСПЕКТ
Authors: ХВЕСИК Михайло , ОБИХОД Ганна , МАНДЗИК Валерій
Published: September 2024

Досліджено інституційні інструменти як важелі впливу на резильєнтність у соціо-еколого-економічних системах. Визначено, що інструменти повинні бути дієвими, достатньо гнучкими і адаптованими до економічних, соціальних та екологічних змін (поступових або таких, що виникають унаслідок надзвичайних ситуацій). Інструментарій є важливим компонентом, оскільки впливає на ефективність реалізації усіх програм розвитку території.
У результаті аналізу світового досвіду формування резильєнтності встановлено, що остання являє собою абсорбційну спроможність природно-ресурсного комплексу, тобто здатність швидко абсорбувати шоки і відновлюватися. Зважаючи на завдання повоєнного відновлення території України, ця властивість стане невід’ємною частиною цього процесу. Проте сучасні наукові дослідження не повною мірою роз’яснюють природу інституціонального забезпечення процесу резильєнтності для природно-ресурсного комплексу (з урахуванням складних характеристик останнього). Інституціональне забезпечення резильєнтності досліджено як результат, зокрема, досвіду і реакції акторів, які стикаються з соціальними і/або екологічними порушеннями.
З огляду на різні аспекти інструментів, які можна використати при формуванні резильєнтності, їх поділено на три основні групи: адміністративні, економічні й ринкові. Власне система інструментів інституціонального регулювання передбачає спільні організаційно-адміністративні й економічні заходи. Завдання інституціоналізації полягає в упорядкуванні ролей і керуванні процесами взаємодії організаційної та економічної складових. Щодо формування й підтримки високого рівня резильєнтності природно-ресурсного комплексу, особливо в умовах наявної невизначеності, окремі завдання і традиційні функції інструментів потребуватимуть удосконалення, оскільки в традиційній ролі вони можуть бути економічно витратними, негнучкими і, як правило, не створюють стимулів для технологічних інновацій. Отже, рекомендовано поєднувати інституціональну складову з економічними передумовами, зважаючи на сучасний стан природного ресурсу або території. Це дасть можливість як вирішити екологічну проблему, так і запобігти її повторенню.
LITERATURA E IMAGEM: DIÁLOGOS CONTEMPORÂNEOS
Authors: MARTINS ALTAIR , MONTEIRO CHARLES
Published: September 2024

Daniela Kern, com "Arte contemporânea e literatura: notas sobre a representação do artista", pensa as formas de criação da arte visual contemporânea. "Imagens da ausência", de Nadja Voss, imbrica palavra e imagem, narrativa e fotografia na obra Bruges-la-morte, de Georges Rodenbach. Fernanda Borges, em "Escrever fotografando e fotografar narrando", analisa literatura e fotografia nas obras de Jonathan Safran Foer e Valêncio Xavier. Em "A imagem-desconhecimento: supremacia branca e genocídio na obra cinematográfica de Raoul Peck", Norman Madarasz escreve sobre o cinema e a palavra na interpretação de memórias traumáticas. Anderson Amaral de Oliveira e Ivo dos Santos Canabarro, em "A representação da memória da Ditadura Civil-Militar Brasileira a partir da fotografia e da obra literária 'A Festa de Ivan Ângelo'", analisam um legado imagético de repressão no Brasil. Fabio Gatti, em "Uma imagem somente é [ ] se ela transforma ou só resta fazer", parte de Fernando de Tacca para entender a escrita durante os processos de criação. Em "Escrita Criativa: o que a escrita devolve à imagem", Altair Martins propõe o uso da Escrita Criativa como fonte de investigação nas relações intersemióticas.
ARTE CONTEMPORÂNEA E LITERATURA: NOTAS SOBRE A REPRESENTAÇÃO
Authors: PINHEIRO MACHADO KERN DANIELA
Published: September 2024

Um dos campos de estudos interdisciplinares que têm apresentado nos últimos anos interessantes desenvolvimentos é o que engloba as zonas de contato entre as áreas da arte e da literatura. Seria possível, na verdade, recuar bastante no tempo em busca de sinais desses contatos e trocas. Mas não indo tão longe, podemos lembrar do pequeno e influente texto de Honoré de Balzac (2000), A obra-prima ignorada, que mereceu leituras atentas de teóricos da arte, de Georges Didi-Huberman a Teixeira Coelho. Este texto trata de representar um artista do século XVII em plena atividade na França, Frenhofer, um Pigmalião moderno que se apaixona pela própria pintura, Catherine, deixando de vê-la como os outros (seus visitantes, os também pintores Poussin e Porbus) a veem.
Design and rationale for a randomized, double-blind, placebo-controlled Phase 2/3 trial of oral arimoclomol in inclusion body myositis
Authors: Machado Pedro M. , Barohn Richard J. , McDermott Michael P. , Sundgreen Claus , Blaettler Thomas , Hanna Michael G. , Dimachkie Mazen
Published: September 2024

Ethical publication statement
We confirm that we have read the Journal’s position on issues involved in ethical publication and affirm that this report is consistent with those guidelines.
 
Disclosure of conflicts of interest
P.M.M. has received consulting fees and funding support from Orphazyme A/S, paid to his academic institution (University College London), for the oversight and conduct of this study.
R.J.B. has received funding from the FDA Office Orphan Products Development grant for his role in this study.
M.P.M. has no relevant conflicts of interest to declare.
C.S. and T.B. are employees of Orphazyme A/S.
M.G.H. receives research funding from the Medical Research Council UK and has previously acted a consultant for Novartis and for Orphazyme A/S.
M.M.D. is a consultant for Orphazyme and received funding support, paid to his academic institution (University of Kansas Medical Center, Research Institute), from Orphazyme A/S for the oversight and conduct of this study.
Design and rationale for a randomized, double-blind, placebo-controlled Phase 2/3 trial of oral arimoclomol in inclusion body myositis
Abstract
Introduction/Aims: Inclusion body myositis (IBM) is the most common progressive, debilitating muscle disease in people over the age of 50 years, for whom there is no effective treatment. Here, we present the design and rationale for one of the largest clinical studies conducted in IBM to date, to evaluate the efficacy, safety, and tolerability of arimoclomol, a novel, oral amplifier of the cellular heat shock response.
Methods: This is a randomized, double-blind, placebo-controlled, parallel group trial conducted at 11 centers in the US and one center in the UK. Eligible patients had a diagnosis of IBM fulfilling European Neuromuscular Centre 2011 criteria, with onset of weakness at > 45 years of age. Enrolled participants were randomized 1:1 to receive either oral arimoclomol citrate 1,200 mg/day or matching placebo for up to 20 months. The primary endpoint is the change from baseline to Month 20 in the IBM functional rating scale (IBMFRS) total score. The secondary efficacy endpoints include evaluations of participants’ functional abilities, strength, and physical health-related quality of life (HRQoL). A sub-study will characterize muscle changes using MRI in a subset of participants.
Discussion: This study will generate important clinical data on a novel therapeutic strategy for patients with IBM, a population with no current treatment options.
КРИТЕРИИ ТВОРЧЕСТВА ДЛЯ ИСКУССТВЕННОГО ИНТЕЛЛЕКТА
Authors: ДЕ АПРО Сона Вагановна
Published: September 2024

В доктрине и научной литературе до сих пор не выработаны универсальные критерии творчества, которые могли бы стать надежными ориентирами в предоставлении защиты прав на результаты интеллектуальной деятельности. Вопрос об авторстве и признании «творчества» искусственного интеллекта также остается открытым. В статье рассмотрена проблема творчества с юридической точки зрения, в частности вопросы охраноспособности произведений, созданных с использованием искусственного интеллекта и непосредственно искусственным интеллектом. Обсуждаются роль воображения в творчестве и другие субъективные факторы, влияющие на творческую деятельность. Изложен взгляд на «мышление» искусственного интеллекта как алгоритмическое, лишенное человеческого духа. Обосновано предложение признать произведения, «созданные» искусственным интеллектом, вторичными, лишенными новизны объектами.
Efecto de la actividad física, las conductas sedentarias y el tiempo de sueño sobre indicadores de salud psicosocial en adolescentes escolares
Authors: Vaquero-Solís Miguel , Sánchez Miguel Pedro Antonio , Tapia-Serrano Miguel Ángel
Published: September 2024

The aim of the present study was to examine the degree to which the combination of healthy behaviors in the 24 h had a greater incidence on subjective happiness and quality of life. A total of 452 adolescent students aged 12 to 17 years participated, both males 258 (13.87 ± 0.77) and females 194 (13.90 ± 0.81). All study variables were measured by self-reported questionnaires: physical activity and sedentary time (I-paq), subjective happiness (SHS) and quality of life (Kidscreen-10). The results of the study were obtained through correlation analysis, linear regression and univariate linear models. It was observed that the behaviors that most predicted subjective happiness and quality of life were sedentary time and sleep time. Also, univariate model analyses revealed that participants who complied with the recommendations of the 24-hour healthy behaviors had higher mean scores in subjective happiness and quality of life than those who did not comply with these recommendations. It is concluded that youth who jointly met the physical activity, sedentary time, and sleep recommendations have greater psychosocial health compared to those who do not.
Analysis Level of Understanding Software Engineering Student in Cisarua Vocational High School on Algorithm Materials: A Mini Research
Authors: Sasmita Firdamdam , Mulyadi Yadi , Sumarto Sumarto
Published: September 2024

The first objective of this study was to determine the distance level of understanding of students and teachers in software majors at SMKN 1 Cisarua. And for the second purpose, the author wants to know the cause of students who excel or do not understand the yahoo material. The research method used is descriptive-based qualitative. The respondents consisted of 3 people, namely teachers, students who excel, and students who do not achieve. Structured interviews, new interviews, recorders, and test sheets were used as tools for collecting data. Each question posed to the respondent is compiled based on the performance criteria in the Indonesian National Work Competency Standards. The data analysis technique used is in the form of a proportion formula. The results show that the teacher understands better than students who excel and students who do not. Students who do not excel better understand than students who do not perform well. And one of the factors that cause students to understand the material is a discussion with upper-level students in the RPL department of SMKN 1 Cisarua. And one of the factors that cause students to be unable to understand the material is the discomfort of students using cell phones as a learning medium.
The Competence of Teachers in Public TVET Institutions in the Khartoum State of Sudan: Challenges and Opportunities
Authors: Gasmelseed Ahmed Mansour Mohammad , Mengistu Melaku , Asrat Dawit
Published: September 2024

This study's primary purpose was to examine public institutions' TVET teachers' competence in Khartoum State and its challenges and opportunities. To this end, the study used an explanatory sequential mixed method design. The researchers used primary and secondary sources of data. The primary sources were students, teachers, managers, and directors whereas the secondary data were relevant policy documents. A total of 815 respondents from 12 TVET institutions were selected using stratified, simple random and purposive sampling. Data collection instruments were questionnaires semi-structured interview guide and Focus Group Discussions (FGD). Quantitative data were analyzed through descriptive (mean scores, standard deviation) and inferential statistics (one and two-sample t-test, one way ANOVA). The qualitative data were evaluated and interpreted with narration. The study found that one, teacher competence is sufficient. Two TVET teachers were effective and competent in their delivery of the training. There was no significant difference between teachers of different TVET institutions in their perceptions about teachers' competence. It recommended that the authorities: establish clear policies and strategies for TVET, allocate the necessary budget, and follow-up to carry out this plan; establish a partnership between industry and TVET to benefit students and compensate for training deficiencies, and be more concerned with teacher training and motivating them by providing their needs.
TVET–Sustainable goals linkage: Inclusive education for a sustainable development
Authors: Adediran Ibraheem Adedayo , Ishola Ajibola Abdulrahamon
Published: September 2024

Technical, Vocational, Education and Training spans our educational systems, from toys for infants to sending children to school to learn Science, Engineering, and Technology. An inclusive society needs real-world education. Equal access for balanced empowerment may be achieved via two techniques. TVET and SDGs work if done well. TVET-SDGs Linkage is a major problem that must be addressed if Nigeria is to fulfil its UN duties, especially in building an inclusive society as outlined in Objectives 4, 5, 8, 10 and 16 of the 17-Point Agenda of the Sustainable Development Goals with 169 goals. Inclusive education promotes a just and equitable society as envisioned by the UN through mobilising stakeholders. The article discusses leveraging TVET to meet Nigeria's SDGs via inclusive education. Secondary schools, vocational centres, technical colleges, polytechnics, and universities must have high-quality teaching and training facilities and highly-trained teaching staff.
Explanatory remark on differences between a position paper and an empirical paper
Authors: Adeoye Moses Adeleke
Published: September 2024

An accessible explanation of academic writing differences between a position paper and an empirical paper for graduate students’ writing approach. The purpose is for graduate scholars who want to use these articles for basic knowledge and fundamental ideas. It can also be used as a textbook or reference. The paper revealed information regarding academic writing differences between position papers, empirical papers and authenticate benefits.  Both position papers and empirical papers involve research and analysis but the main difference is that position papers present a specific stance or argument while empirical papers present objective data and research findings. It was concluded that a position paper and an empirical paper focus on argumentation persuasion versus original research create a new body of knowledge scientifically.
Required competencies by the industry for logistic engineering graduates: A systematic review
Authors: Putra Davin Arkan Admoko , A Ana , Dwiyanti Vina
Published: September 2024

Logistic Engineering is a new-promising discipline that supports the ongoing trend of the logistics market in Indonesia. Vocational education has not accommodated the demands and needs of the industry. This paper aims to list the required skills for logistics professionals from a global perspective. A Systematic Literature Review (SLR) method using articles obtained from national and international journals in the last two decades.  The skills required are divided into two, technical competencies and soft skills. The result of the findings states that graduates are required modern skills that involves cross-functional, IT, and environmental as their advanced competency based on the specific logistic professional scope.  It is also noted that these advanced skills must expand to the direction of specific logistic skills to suit their profession responsibilities. Core or primary skills including logistic knowledge, management, and intrapersonal was summarized on general consensus of global profession requirements. Thus, vocational education must train current and advanced technical competencies to meet global requirements.
Los archivos son máquinas: una revisión de los discursos artísticos sobre arte y archivo en Iberoamérica, 2011-2022
Authors:   Universidad de Antioquia, Tobón Daniel Jerónimo , Giraldo Marta Lucía ,   Universidad de Antioquia, Villegas Andrés ,   Universidad Nacional de Colombia, Coimbra Jose Cesar ,   Pontifícia Universidad Católica de Río de Janeiro
Published: September 2024

Este artículo ofrece un análisis crítico del uso del término archivo en las discusiones sobre artes visuales en Iberoamérica entre 2011 y 2022: ¿Por qué ha cobrado vigencia este término en el mundo del arte iberoamericano durante las últimas décadas? ¿Para qué se utiliza? ¿Cómo funcionan las obras de arte cuando se las entiende como archivos? ¿Cuáles son los temas principales en estas discusiones? Se propone enmarcar este análisis en cuatro hipótesis interpretativas. 1) El uso del término archivo en las discusiones sobre artes visuales iberoamericanas actuales se puede entender mejor a través del modelo de la máquina, es decir, en términos de las funciones que desempeña. 2) Los archivos en las artes visuales iberoamericanas tienen tres funciones básicas: coleccionar, montar y movilizar. 3) Los archivos son máquinas comunitarias: surgen de comunidades, crean comunidades y requieren comunidades para su funcionamiento. 4) Los archivos son máquinas del tiempo: moldean nuestra memoria y nuestro futuro. Entender los archivos como máquinas nos permite ver cómo las prácticas artísticas y las discusiones sobre archivos en las artes visuales iberoamericanas están vinculadas con aspiraciones compartidas de tramitar pasados violentos e historias de exclusión, con la necesidad de fortalecer la deliberación pública y con la voluntad de defender la democracia. En esta región, las relaciones entre arte y archivo han permitido leer la historia a contracorriente y articular el trabajo de artistas, archiveros, comunidades y gestores culturales con las demandas concretas de los movimientos sociales y su necesidad de reconocimiento. Las poéticas del archivo en las artes visuales en Iberoamérica se orientan a la creación de lo nuevo, no a la repetición del pasado.
Temperature anomalies in October 2023 in Ukraine
Authors:   Odessa State Environmental University, Odessa, Ukraine, Nazhmudinova Helena N.
Published: September 2024

The duration of summer in Ukraine may increase because of climate change, which causes abnormal modes of atmospheric circulation. In recent decades, heat waves have become more frequent in Ukraine not only at the beginning of autumn but also in the middle of the season. The study examines the extreme temperature regime of October 2023 in Ukraine. The objective of the study is to establish the causes and conditions for the formation of high positive air temperature anomalies. The average monthly air temperature across the country turned out to be higher than the climatological normal. The anomalies ranged from a high of 3,4...4,9 °C in the Odesa region to minimum deviations in the Sumy region: 0,9...2,0 °C. The course of temperature during the month was heterogeneous, short periods of frost were observed, and the daily amplitude at a number of weather stations often exceeded 15...20 °C. Extreme conditions developed in the third decade with the propagation of a heat wave in the system of a powerful subtropical crest from the region of Asia Minor. The largest deviation in the average daily temperature was recorded on October 21-22 – up to 10...12 °C in Odesa, Mykolaiv, and Chernivtsi regions. The highest anomaly was registered in the Odesa region – a new absolute maximum was set at 8 weather stations, and the maximum temperature extremum on the 21st was 34,0 °C at the Sarata weather station. Positive temperature anomalies were observed in the entire troposphere, at the level of 925 hPa – up to 8 °C, at 850 hPa – up to 12...14 °C. During this period, there was an extremely high thermal gradient between the northern and southern regions (up to 25 °C), which were under the influence of baric systems of different signs. The form of the blocking process "omega-shaped crest" characterized the high-altitude thermobaric baric field over Eastern and Central Europe, a powerful anticyclone was established in place of the Icelandic minimum with a positive H500 geopotential anomaly of up to 20 dams. Objective signs of blocking on the Lejenas index and Okland I(λ) determined critical levels over Europe. The accumulation of the main heat flow was facilitated by several short heatwaves during the month (lasting up to 3 days), as well as the formation of a marine heat wave in the western Mediterranean with sea surface temperature anomalies of up to 3 °C.