bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of Precision Nutrient Management on Rice Growth and Productivity in Southern Odisha
Authors: Sagar Lalichetti , Maitra Sagar , Singh Sultan , Sairam Masina
Published: August 2023

Background: Despite the emergence of numerous smart tools in recent times, a significant research gap still exists in identifying the most effective smart tool that optimally synchronizes fertilizer application with crop requirements, thereby promoting crop growth and productivity in accordance with the principles of SSNM. Methods: The present investigation took place at the PG Experimental Farm, MSSSoA, CUTM, Odisha, during the boro season of 2021-22.The experiment followed a randomized block design, with eleven treatments that were replicated three times. The investigated treatments included the following: T1-absolute control (no fertilizer), T2-75% of the recommended dose of fertilizer (RDF), T3-100% RDF, T4-125% RDF, T5-75% RDF followed by a spray of nano urea at a rate of 2ml/L during panicle initiation, T6-100% RDF followed by a spray of nano urea at a rate of 2ml/L during panicle initiation, T7- leaf colour chart (LCC) 3 based nitrogen management,, T8-LCC 4 based nitrogen management, T9- Sufficiency Index (SI)-based nitrogen management at SI less than 90%, T10- Nutrient expert (NE)-based nutrient recommendation, and T11- Rice crop manager (RCM)-based nutrient recommendation. Result: The study found that implementing nitrogen management based on site-specific information, using a total of 150 kg of nitrogen per hectare applied in four separate applications (at the basal stage, 28 days after transplanting, 42 days after transplanting, and 63 days after transplanting), along with consistent levels of phosphorus and potassium, led to a 16.68% increase in grain yield and a 13.17% increase in biological yield for rice. This approach outperformed the traditional method of applying 100% recommended dose of fertilizer with 120 kg of nitrogen at fixed time intervals (basal, active tillering, and panicle initiation).
Exploitation of Host Resistance: A Promising Alternative Approach to Control Gastrointestinal Nematodoses in Small Ruminant: A Review
Authors: Jas R. , Hembram, A. , Das S. , Biswas J. , Pandit S. , Baidya S. , Rai S.
Published: August 2023

Gastrointestinal nematodes (GINs) are the most insidious pathogens causing severe economic losses to the livestock industry. Among GINs Haemonchus contortus is the most pathogenic and predominant parasite of small ruminant livestock. Although the use of chemical anthelmintics is still the corner-stone of control method for GINs, the increasing rate of prevalence of anthelmintic resistance has made it less reliable control option. Anthelmintic resistance together with global demands for chemical residue free animal product has led to search for alternative sustainable control strategies which rely less on chemical anthelmintics. One of such strategy is the exploitation of host resistance against the GINs including H. contortus. The resistance of animals to GINs varies within and between breeds of sheep and goats. Host immune response plays an important role in host resistance but the immune mechanisms responsible for resistance are not fully known. Studies on identification of gene/(s) responsible for host resistance are also being carried out to find out the molecular mechanism of GINs resistance in sheep and goats all over the world. Selective breeding for GINs resistance is the ultimate solution for the problems of anthelmintic resistance. This article reviews the published reports on GINs resistance in relation to immunological response and genetic studies in small ruminants and discusses the prospects for selective breeding of GINs resistance in sheep and goat.
Polymorphic Variants Analysis in Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Alpha (PPARGC1A) Gene of Indian and Egyptian Buffaloes
Authors: Sihag Sonia , Rushdi Hossam E. , Kumar Anil , Jangra Alka , Hassanane Mohamed S. , Abdel-Shafy Hamdy , Chhokar Vinod
Published: August 2023

Background: Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A) is a candidate gene for milk fat in livestock. The present study was carried out to investigate polymorphism in PPARGC1A and study its potential association. Methods: Two hundred forty animals from Murrah and Bhadawari Indian buffalo breeds and Egyptian buffaloes were selected. The statistical analysis used was Tukey’s honest significance test to investigate the association of different genotypes. The PCR-SSCP (polymerase chain reaction-single strand conformation polymorphism) assays and sequencing technologies were used to confirm the SNPs. Results: Three Novel single nucleotide polymorphisms (SNP1- g.993A greater than T, SNP2- g.1237T greater than A and SNP3-g.1238G greater than C) and one insertion (g.1240_ greater than G bp) were identified in this gene. Due to nucleotide mutations, four non-synonymous mutations were observed in amino acid sequences of buffalo breeds. Significant differences in protein and SNF output were discovered in Egyptian buffalo breeds. In both Murrah and Bhadawari buffaloes, fat, protein and SNF yield were substantially correlated with detected genotypes while there was non-significant association of protein and SNF percent in buffalo breeds. The information provided will be valuable in studying the involvement of PPARGC1A in regulating fat synthesis and enhancing milk quality in buffaloes.
Effect of Genetic and Non-genetic Factors on Semen Quality Traits in Bovine Breeding Bulls
Authors: Singh Palpreet , Kaur Simarjeet , Kumar Ajeet , Mukhopadhyay C.S. , Kashyap Neeraj , Dubey P.P.
Published: August 2023

Background: A breeding bull is used to serve many females; therefore, for overall herd fertility, the bull's fertility is more important than female fertility. Methods: The present study was carried out to compare the effects of species, season, period, and interaction between species and season on the semen quality traits of Murrah buffalo and crossbred cattle bulls. For the 25-year study period, a total of 26205 ejaculation records of 389 bovine breeding bulls, including Murrah buffalo and crossbred cattle bulls, were analysed that were maintained at an organised farm. Result: Species and period of semen collection had a highly significant effect on all the traits (P less than 0.01). Season of semen collection and interaction between season and species had a highly significant effect (P less than 0.01) on semen volume (SV), consistency, mass activity (MA), total sperm count (TSC), initial motility (IM) and post-thaw motility (PTM), a significant effect (P less than 0.05) on age at first semen collection (AFSC) and non-significant effect on the semen colour and age at first semen freezing (AFSF). Overall, semen quality was good at the organised farm during all seasons. In bovine breeding bulls, PTM during the rainy and summer seasons was comparatively low. An overall increase in semen quality in the later periods showed progressive improvement in management at the organised farm over the period.
Comparing competitive team-based learning with other instructional methods and approaches
Authors: Hosseini Seyed Mohammad Hassan
Published: August 2023

Having introduced Competitive Team-Based Learning (CTBL), this paper presents a cogent and critical analysis and comparison of CTBL with other popular methods and approaches in the arena of Education in general and Language Teaching in particular, in terms of their distinguishing features and characteristics. Among such methods and approaches are Communicative Language Teaching (CLT), Collaborative Learning (ColL), Interactive Learning (IntL), and Cooperative Learning (CL)/methods which are appreciated particularly in the U.S. and in the West. A synthesis of the distinguishing drawbacks of the comparison methods and approaches is considered in this article. The article also explicates how CTBL, this researcher’s educational innovation, which has been formulated based on his edu-political theories in the last analysis, is an approach to human security and prosperity, and world peace. This article would contribute to making a sound decision on implementing CTBL in the arena of Language Teaching/Education for the ultimate goal of peace-making and more compassionate civilization building.

Keywords: Competitive team-based learning; edu-political theories; interactive learning; cooperative learning; collaborative learning
Aconteceres en el aula de matemáticas
Authors: González Gutiérrez Nelsy Rocío , Sepúlveda Delgado Omaida , Casas Rodríguez Laura Ximena , Riscanevo Espitia Lida Esperanza , Hurtado Martínez Miguel Ángel , Niño Castillo Yuri Carolina
Published: August 2023

Este libro presenta los resultados del trabajo de un semillero de investigación, apoyado en procesos colaborativos entre docentes y estudiantes de matemáticas. Muestra de forma creativa la teoría y la práctica, tanto de la matemática como de la educación matemática en un lenguaje no hermético, y expuesto a través de la experiencia de los investigadores que entre cuestionar, interpretar resultados y plantear conclusiones dan a conocer cómo los estudiantes son forjadores de conocimiento matemático, y cómo los profesores y formadores de profesores constituyen saberes sobre la educación matemática. De esta manera, desde el aula de clase, las voces de los docentes e investigadores guían el ejercicio investigativo, favoreciendo así las posibilidades de transformación curricular ,fortalecimiento del desarrollo profesional y el planteamiento de posibles soluciones a las falencias en los procesos de enseñanza y aprendizaje de las matemáticas, en contextos de educación básica y media, así como en las aulas de didáctica de la matemática de los programas de licenciatura en matemática y maestría en educación matemática.
Quantitative determination of total flavonoids in Glycyrrhiza Glabra L. herbs
Authors: Belova O. A. , Kurkin V. A. , Egorov M. V.
Published: August 2023

Licorice herb (Glycyrrhiza glabra L.) is a promising herbal raw material, which can be comprehensively used to develop drugs with an anti-inflammatory action.

The aim of the article was to development a quantitative determination method of total flavonoids in Glycyrrhiza glabra L. herbs.

Materials and methods. The subjects of research were 5 samples of licorice herb harvested in summer in various places of growing and cultivation. Pinostrobin was used as a standard sample. The registration of the electronic spectra was carried out with a spectrophotometer (Analytik Jena AG, Germany) by differential spectrophotometry, 96% ethanol was used as a solvent.

Results. The methods for quantitative determination of total flavonoids in Glycyrrhiza glabra L. was carried out at an analytical wavelength of 310 nm equivalent to pinocembrin. The optimum parameters for the extraction of total flavonoids from Glycyrrhiza glabra L. were as follows: the extractant – 90% ethanol; the «raw material-extractant» ratio was 1:50; the extraction time was 60 min; the degree of atomization was 2 mm. The content of total flavonoids for the Glyccyrhiza glabra L. herb has been determined, it varies from 0.39±0.002 to 3.41±0.015% with the humidity of the vegetative raw material from 9.97±0.003 to 10.03±0.003% depending on the place of the vegetation, cultivation and year of the raw material collection. The error of the single determination with a 95% confidence level was ±0.73%.

Conclusion. The developed methods for the quantitative determination of total flavonoids in Glycyrrhiza glabra L. herbs can be used to solve the issues of standardization of these medicinal plant raw materials.
Analysis of cytokine response characteristics and immunopathogenetic effects of double-stranded sodium salt RNA-based drug for postexposure prophylaxis against novel coronavirus infection: double-blind, placebo-controlled trial
Authors: Radaeva O. A. , Balykova L. A. , Zaslavskaya K. Ya. , Kostina Yu. A. , Pyataev N. A. , Selezneva N. M. , Klimova A. V. , Chegodaeva I. Yu. , Koryanova K. N. , Taganov A. V. , Bely P. A.
Published: August 2023

The aimof the workwas to study сytokine response characteristicsin the group of persons contacted by a novel coronavirus infection depending on the development of the disease over the next 14 days. Herewith, for the immunocorrection with a preparation based on RNA double-stranded sodium salt (RADAMIN®VIRO) causing a secondary reduction in the risk of COVID-19 in the analyzed group, potential targets had been selected.

Materials and methods.A double-blind, placebo-controlled study of the drug based on RNA double-stranded sodium salt therapeutic effects was conducted in a group of patients who had been in contact with the persons having a confirmed diagnosis of COVID-19. The method of enzyme immunoassay in dynamics was used to determine the content of interferons alpha and beta (IFNα and IFNβ, respectively), interleukin-1β and -10 (IL1β and IL-10, respectively) in the blood serum and saliva in the contact persons, with a retrospective assessment of changes depending on the administration of the drug or placebo, as well as the development of COVID-19.

Results.In the course of the presented study, it was demonstrated that the established content of IFNα (less than 28 pg/ml) and IFNβ (less than 12 pg/ml) in saliva on the 1st–2ndcontact days is a predictor of an increased risk of developing COVID-19. Herewith, the increase degree in these immunoregulatory peptides in the interval of 2–3 contact days is important: IFNα and IFNβ allows leveling the negative prognosis in patients by 250% or more. The lowest rates (p <0.001) of INFα on the 1st–2ndcontact days, as well as an increase of less than 21% by the 3rdday, were observed in persons with a waist circumference of more than 80/94 cm (women/men). The incidence in this group was higher and amounted to 85% (16 out of 20 people). The predictor role of IL-1β and IL-10 in the blood and saliva in relation to the start of the infectious process was not revealed. The administration of drug based on RNA double-stranded sodium salt to the contact patients made it possible to correct the interferon response in the form of an increase in the content of IFNα and IFNβ, as well as to reduce the incidence in comparison with the placebo group.

Conclusion.Differences in the interferon regulation upon contact with SARS-CoV-2 in the form of lower INF α and β levels, as well as a slightly pronounced growth dynamics in the interval of the first 3 days, influenced the increased risk of developing COVID-19. RADAMIN®VIRO can be recommended as a means of post-exposure prophylaxis of COVID-19 for both medical institutions and for caregivers and / or contacts with COVID-19 patients.
New role of extemporaneous manufacturing in regulating drug products access onto the market
Authors: Alekhin A. V. , Erivantseva T. N. , Ryazhenov V. V. , Lyskov N. N. , Alekhina N. A. , Kuznetsova M. M.
Published: August 2023

The aim of the work was to study the legal aspects of the legislative regulation for manufacturing medicines in a pharmacy organization.

Materials and methods. Databases of ConsultantPlus, Cyberleninka, Food and Drug Administration (FDA), European Medicines Agency (EMA), National Center for Biotechnology Information (NCBI), PubMed, e-library, WIPO Lex were used as search sources. The search was based on the following keywords and phrases: intellectual property, pharmacies+invention, patent, drugs, extemporal+production, orphan+diseases, as well as their Russian counterparts. 133 sources of information, including scientific articles and regulations, were found out; 50 have been included in this review. The analysis of information sources published from 2013 to 2023, was determined by the peculiarities of legislation changes in this area.

Results. The article provided an overview of modern, including regulatory practice, pharmaceutical manufacturing in the Russian Federation, and also analyzed the benefits of this activity for the medical community, patients and the state. At the same time, the individualization of drug treatment has made it possible to work out systemic solutions for developing drug therapy methods for special groups of patients for whom the economic feasibility of a pharmaceutical registration and launching such drugs onto the market has been brought into challenge. In addition, pharmacy manufacturing is an accessible tool in the study of the drugs prescribed by a doctor not in accordance with the instructions for medical use (off-label) or in the dosage forms/dosages that are not on the market. Extemporaneous manufacturing can be also a part of the process of “repositioning” drugs on the market, subject to compliance with the requirements for pharmacy manufacturing and control of the prescribed drugs safety. The possibility of pharmaceutic drug manufacturing also makes it possible to partially resolve issues related to intellectual property. As a result of the carried out analysis, the following hypothesis was confirmed: the legislative changes have a similar legal assessment both in Russia and abroad and correspond to the legal practice in resolving intellectual property issues in relation to pharmacy organizations.

Conclusion. The renewal of a pharmacy production will improve the availability of the drug care to the population, taking into account individual dosages and dosage forms in various therapeutic areas, and can also become a tool for repositioning drugs or clinical testing of new molecules for rare incurable diseases.
The Law Tech Clinic: Leading the way in Entrepreneurial Law Clinics
Authors: Weinberg Jacqueline , Hyams Ross
Published: August 2023

Globalisation, economic forces and technological advancements are changing the way law is practised. Clients are seeking innovative solutions to an increasingly broad range of legal challenges. They want greater connectivity and streamlined delivery of legal services. The rate of change has accelerated in response to remote working, with the digital maturity of legal firms advancing more rapidly than ever before, utilising technology such as electronic billing practices, digital mailrooms, e- discovery, digital document signing and workflow automation.

Newly developed and deployed legal technology within the sector has increased demand for lawyers with the skills to adapt and thrive in a technological environment. Law firms favour graduates with a ‘technology mindset’ and aptitude to think beyond the traditional professional services model. The Monash University Faculty of Law, one of the leading law schools in Australia with a pioneering clinical program, has established a Law Tech Clinic (LTC). The LTC provides a unique opportunity for students to work on real client matters and receive end-to-end industry input to develop client-ready applications.

This paper describes the LTC’s structure and how the clinic is designed to educate students on the changing demands of the legal industry, providing practical knowledge on legal technology usage to advance legal services. This paper outlines how the LTC enables students to develop professional and practical legal skills that will help them become successful entrepreneurial lawyers, adept at integrating technology with innovative legal services. Further, this paper demonstrates how the Monash Clinical Program, with a strong focus on best practice in clinical legal education, provides a perfect forum to run such a clinic. We demonstrate how students work with technological systems to assist industry partners, law firms and other organisations and provide accessible legal services to their clients.2 Finally, this paper highlights how the LTC educates students on technological advances in legal practice, equipping them with frameworks for the knowledge, skills and attributes to be technologically proficient future legal practitioners. Although this discussion is in the Australian context, it can also apply to other jurisdictions as the associated issues with legal technology and its effects on legal practice are occurring globally.
The Barriers to the CLE Practice in Russia, in Comparison Light with the European Union and the United Kingdom
Authors: Kislova Alina
Published: August 2023

Clinical legal education (CLE) is commonly used to refer to a law teaching method that incorporates experiential learning aimed at development of students’ legal knowledge and skills. At the same time, CLE also has social justice mission as it serves the needs of vulnerable members of society. Like any other teaching methods, CLE requires a specific environment and factors to be in place to embrace its mission at maximum level and to allow its learners to reach pre-defined learning outcomes. While researching in three Western European university legal clinics, and then studying the legal clinics in Russia, I have reached the conclusion that CLE in Russia cannot fully exploit its mission and reach its objectives. While some barriers that prevent Russian universities to effectively run CLE are obvious, there are also the ones which will be new to a reader. Below I discuss the factors that could be considered as barriers preventing CLE practice in Russia to be effective in driving for its mission and goals, both from educational and social justice perspectives.
Rancang Bangun Aplikasi Pencatatan Arus Kas Klinik PDGI Karawang Dengan Model Extreme Programming
Authors: Ratnawati Ratnawati , Yuliana Yuliana , Benazir Puspa , Destiani Putri Sagita
Published: August 2023

Abstrak Ã¢â‚¬â€œ Penyampaian laporan kas kepada pimpinan di sebuah perusahaan merupakan hal yang sangat sensitif karena hal ini berhubungan dengan keuangan perusahaan. Oleh karena itu dibutuhkan ketelitian serta kelengkapan data dari semua transaksi yang terjadi. Klinik PDGI Karawang masih memiliki keterbatasan dalam penyampaian laporan kas ini karena pencatatan manual dengan mengetik data transaksi satu persatu ke dalam spreedsheet masih dilakukan sampai saat ini. Hal ini tentu akan memerlukan dua kali durasi pencatatan saat akan pembuatan laporan di akhir bulan. Selain itu data yang semakin bertambah banyak akan memerlukan file yang cukup banyak pula karena pencatatan dipisahkan setiap satu bulan. Penggunaan sistem informasi tentu dapat menjadi solusi yang baik terutama dengan integrasi basis data, maka data lama dapat disimpan dalam satu tempat namun juga tetap mudah untuk dipanggil kembali. Tujuan penelitian ini adalah untuk membangun sebuah sistem yang dapat digunakan oleh klinik PDGI untuk dapat melakukan pencatatan kas yang tersistem dengan baik.Pada penelitian ini penulis menggunakan model exterme programming dalam membangun sistem informasinya. Wawancara mendalam, observasi sistem secara langsung serta kajian pustaka menjadi teknik yang kami gunakan untuk mengumpulkan data pendukung. Kelebihan aplikasi ini dilengkapi dengan informasi posisi kas pada halaman utamanya. Terwujudnya sebuah sistem baru yang dapat digunakan oleh administrasi keuangan klinik PDGI dalam merekam semua transaksi keuangan baik yang masuk ke dalam perushaan maupun yang dibelanjakan merupakan hasil pada penelitian kami.
ANALISIS TINGKAT USABILITY PADA APLIKASI PEDULILINDUNGI MENGGUNAKAN METODE SYSTEM USABILITY SCALE
Authors: Defensia Angeline , Maulana Ade , Pratama Yudhistira Adhitya , Jusin Jusin
Published: August 2023

PeduliLindungi adalah sebuah aplikasi yang dibuat oleh pemerintah untuk mengendalikan penyebaran virus COVID-19, memberikan informasi, serta melacak individu yang terinfeksi. Pengguna aplikasi ini diharuskan untuk mengakses dan menggunakan sistem yang ada. Aplikasi PeduliLindungi juga dilengkapi dengan berbagai fitur yang bertujuan untuk mengendalikan penyebaran informasi dan virus COVID-19. Untuk mengevaluasi kualitas suatu aplikasi, peneliti menggunakan metode usability. Metode ini menggunakan skala penilaian dengan angka 1 hingga 5. Nilai ganjil (1, 3, 5) dikurangi 1, sedangkan nilai genap (2, 4, 6) dikurangi 5 dari nilai yang diberikan oleh responden. Penelitian ini juga melibatkan responden dengan karakteristik yang berbeda, seperti jenis kelamin, usia, dan status pendidikan. Responden kemudian dikelompokkan menjadi dua kategori, yaitu mahasiswa dan masyarakat umum. Hasil penelitian menunjukkan bahwa baik mahasiswa maupun masyarakat umum memperoleh grade Marginal High. Berdasarkan hasil penelitian, terdapat beberapa rekomendasi untuk memperbaiki aplikasi. Salah satunya adalah memberikan penjelasan yang lebih jelas mengenai fitur-fitur aplikasi serta melakukan perbaikan pada sistem scan QR Code yang mengalami beberapa bug.
Pengaruh Jenis dan Konsentrasi Pupuk Organik Cair Terhadap Pertumbuhan dan Hasil Tanaman Kailan (Brassica Oleraceae L.) dengan Sistem Hidroponik Substrat
Authors: Masitoh Dewi , Subroto Gatot
Published: August 2023

In Indonesia, kailan plants are classified as new plants but have quite large prospects, however, kailan production in Indonesia is still relatively low and is not comparable to the increasing demand for kailan and the availability of agricultural land which is still limited. The use of liquid organic fertilizer with the application of a substrate hydroponic cultivation system is a good alternative in a cultivation system to increase yields in terms of quality and quantity. It is necessary to do research on the effect of the right type and concentration of liquid organic fertilizer for kailan plants. This study aims to determine the effect of the right type of liquid organic fertilizer and the concentration of good liquid organic fertilizer on the yield of kailan plants. The research was conducted in August-October 2022 which took place in Patrang, Jember Regency. This study used the RAL method (Completely Randomized Design) which was arranged in a factorial manner consisting of 2 treatment factors which were applied to kailan plants which were repeated 3 times. The first factor is the type of liquid organic fertilizer (P), which consists of three levels, namely: Rabbit Urine (P1), Nasa (P2), and Cow Biourine (P3). The second factor was the concentration of liquid organic fertilizer (K) which consisted of 4 levels, without POC treatment (K0); 10 ml/l water (K1); 20 ml/l water (K2); 30 ml/l water (K3); 40 ml/l water (K4). The data obtained will be analyzed using analysis of variance (ANOVA). Treatments with significantly different effects were further analyzed using Duncan's test at the 5% level. Based on the data and discussion of the research that has been done, it can be concluded that the best type of liquid organic fertilizer concentration treatment is the Nasa liquid organic fertilizer type treatment, while the more efficient liquid organic fertilizer concentration treatment used to be applied in the kailan cultivation system is the kailan plant treatment. concentration of liquid organic fertilizer 30ml/L. There is an interaction between the types of liquid organic fertilizer treatment at the concentration level of liquid organic fertilizer on the plant wet weight parameter.
Pengaruh Fungi Mikoriza Arbuskula dalam Aklimatisasi Planlet Kentang (Solanum Tuberosum L.) Kultivar Granola dan Atlantik Hasil Kultur Jaringan
Authors: Widhiantoro Noval Wahyu , Slameto Slameto
Published: August 2023

Potatoes are a commodity that has high carbohydrates after rice, wheat and paddy which makes potatoes one of the most popular commodities. The high level of seed-borne pathogen infection causes decreased productivity. Tissue culture is one of the methods used to minimize the level of pathogen contamination. The acclimatization phase is a very crucial phase because at this stage it is hoped that potato plants which were previously in in-vitro conditions can adapt to the in-vivo environment. Arbuscular mycorrhizal fungi are fungi that can form a symbiosis with plants. The symbiosis that occurs is that mycorrhizae are able to produce growth hormone which can also help in carrying out nutrient uptake. This experiment was conducted using a factorial Completely Randomized Design (CRD), which consisted of two factors. The first factor is potato cultivar which consists of granola cultivar (K1) and Atlantic cultivar (K2) and the second factor is mycorrhizal dose (M) which consists of 4 levels, namely without mycorrhizal (M0), mycorrhizal dose of 1 gram (M1), mycorrhizal dose of 3 grams (M2), and mycorrhizal dose of 5 grams (M3). The experimental results were analyzed using analysis of variance (ANOVA) and if there was a significant difference, further tests were carried out using the Least Significance Diffent (LSD) test at the 5% level. Based on the experimental results, it was shown that mycorrhizal administration had a significant effect on the parameters of plant height and leaf area. The potato cultivar factor did not have a significant effect on all observation parameters. As well as the treatment of mycorrhizal factors and potato cultivars did not show any interaction on all observation parameters.
Inovasi Budidaya Tanaman Gambas (Luffa acutangula) Kajian Aplikasi Pupuk Cair Organik dan Petroganik
Authors: Helilusiatingsih Nunuk
Published: August 2023

The luffa plant of the Cucurbitaceae family or the pumpkin tribe has a high content of vitamins, A, B, C, high fiber, the fruit is green in color, the skin is rather rough and is used for vegetables. Gambas is popular with the public because it tastes slightly sweet,, is often used in various dishes because its nutritional value is very good for the immune system. The problem that occurs is gambas is a vegetable that is less popular than cucumber, lettuce, mustard greens, and others and in Kediri its production has decreased due to factors that support development, there are problems, especially the use of fertilizers. The aim of the experiment was to study the innovation of squash cultivation with the application of POC and Petroganik on the effect of the interaction between the treatment combinations in increasing the growth and production of the squash plant. Experimental design using Factorial RAK, with experimental treatment to one dose of POC consisting of 3 levels 8 ml/L, 10 ml/L, 12 ml/L and the second petroganic dose is 10 tonnes/Ha, 12 tonnes/Ha, 14 tonnes/Ha , there were 9 combinations, repeated 3 times and there were 27 experimental units.  The results showed that there was a significant effect and interactions occurred in the combination of treatments, the best data was P3N3 (Petroganik 14 ton/Ha and POC 12 ml/L) which produced a plant height of 1.91 cm, number of leaves 47.38, number of fruit 8.57 , Fruit weight 850.37 grams, fruit length 32.65 per plant. So innovations in the cultivation of gambas plants should use the best treatment, namely P3N3, and other factors that must be considered include quality seeds, soil must have good physical and chemical properties, a climate that supports growth, environmental temperature around 25-280 C. And pH around 5,6.
Pengelompokan Peserta Program Merdeka Belajar-Kampus Merdeka (MBKM) Berdasarkan Perguruan Tinggi dengan Analisis Cluster Non Hierarki Metode K-Means
Authors: Wananda Titania Tasya , Jaka Nugraha
Published: August 2023

Merdeka Belajar-Kampus Mengajar (MBKM) merupakan program Kementrian Pendidikan dan Kebudayaan yang bertujuan agar menghasilkan kualitas Pendidikan yang lebih baik seperti mahasiswa yang memiliki kemampuan analisis yang tajam dan pemahaman komprehensif dalam mengembangkan diri. MBKM terdiri dari beberapa subprogram diantaranya yaitu magang, studi independent, kampus mengajar, dan lainnya. Jumlah mahasiswa peserta program magang, studi independent, dan kampus merdeka berjumlah 40.944 mahasiswa, sedangkan total mahasiswa secara keseluruhan sebesar 9.188.101 mahasiswa. Tujuan dari penelitian ini untuk mengetahui bagaimana tingkat partisipasi mahasiswa dari setiap perguruan tinggi dalam program MBKM dengan menggunakan analisis cluster K-Means. Pada penelitian ini terbentuk 2 cluster dengan jumlah anggota cluster 1 sebanyak 17 perguruan tinggi dan cluster 2 sebanyak 1359 perguruan tinggi. Cluster 1 memiliki karakteristik peserta program magang dan studi independent tergolong rendah, sedangkan peserta kampus mengajar tergolong tinggi. Cluster 2 memiliki karakteristik peserta program magang dan studi independent tergolong tinggi, sedangkan peserta kampus mengajar tergolong rendah.
Solid Precipitation and Visibility Measurements at the Centre for Atmospheric Research Experiments in Southern Ontario and Bratt’s Lake in Southern Saskatchewan
Authors: Boudala Faisal S. , Milbrandt Jason A.
Published: August 2023

Accurate measurement of solid precipitation (S) has a critical importance for proper understanding of the Earth’s hydrological cycle, validation of emerging technologies and weather prediction models, and developing parameterizations of severe weather elements such as visibility (Vis). However, measuring S is still a challenging problem mainly because of wind effects. The wind effects are normally mitigated by using a Double-Fence Automated Reference (DFAR) system to reduce the wind speed (Ug). To contribute towards addressing some of these issues we have analyzed data sets collected at a site located in Southern Ontario, Canada using several instruments. The instruments include two Geonor gauges, one placed inside a DFAR (SDFAR) and the other inside a double Alter shield (DASG), a Pluvio2 gauge inside a single Alter shield (SASP), a HotPlate, a PARSIVEL2 Disdrometer that measures S and fall velocity (V), and a FD12P senor that measures S and type and Vis. The results show that for the Ug observed in this study (Ug < 6 ms-1), both DASG and SASP have similar collection efficiency (CE) of near 70%. The transfer functions (TF) for DASG and SASP as a function of Ug and also Ug, and V have been derived. The TF for the DASG that includes both Ug and V showed better agreement with observation than just Ug alone. The S measured using all the other instruments were correlated well with SDFAR, but the PARSIVEL2 and FD12P overestimated and underestimated the snow amount respectively as compared the SDFAR. However, the HotPlate captured similar amount of S as the SDFAR. According to this study, the SDFAR showed good correlation with Vis.
Contextuality in Collective Intelligence: Not There Yet
Authors: Sulis William , Khan Ali
Published: August 2023

Type I contextuality or inconsistent connectedness is a fundamental feature of both the classical as well as the quantum realms. Type II contextuality (true contextuality or CHSH type contextuality) is frequently asserted to be specific to the quantum realm. Nevertheless, evidence for Type II contextuality in classical settings is slowly emerging (at least in the psychological realm). An example is given here of Type II contextuality involving a simple cooperative game. This arises due to the cooperative nature of the game which results in sign intransitivity for expectation values while individual random variables remain consistently connected. This shows that the conditions attributed uniquely to quantum systems may occur in classical settings as well. Sign intransitivity can be observed in preference relations in the setting of decision making and so intransitivity in decision making may also yield examples of Type II contextuality. Previously it was suggested that a fruitful setting in which to search for such contextuality is that of decision making by collective intelligence systems. An experiment was conducted using a detailed simulation of nest emigration by workers of the ant Temnothorax albipennis. In spite of intransitivity, these simulated colonies came close to but failed to violate Dzhafarov’s inequality for a 4-cyclic system. Further research using more sophisticated simulations and experimental paradigms is required
Anabolic resistance in the pathogenesis of sarcopenia in the elderly
Authors: Tezze Caterina , Sandri Marco , Tessari Paolo
Published: August 2023

The development of sarcopenia in the elderly is associated to many potential factors and/or processes, that impair the renovation and the maintenance of skeletal muscle mass and strength as ageing progresses. Among them, a defect by skeletal muscle to respond to anabolic stimuli is to be considered.
Common anabolic stimuli/signals in skeletal muscle are hormones (insulin, growth hormones, IGF-1, androgens, β-agonists such epinephrine), substrates (amino acids as protein precursors on top, but also glucose and fat, as source of energy), metabolites (such as β-agonists and HMB), some cytokines, various biochemical/ intracellular mediators), physical exercise, neurogenic and immune-modulating factors, etc. Each of them may exhibit a reduced effect upon skeletal muscle as ageing progresses.
In this review article, we will concisely overview the effects of anabolic signals on muscle metabolism, as well as currently available evidence of a resistance, at skeletal muscle level, to any of the above-mentioned anabolic factors, from both in vitro and in vivo studies.
A Global Structural Hypergraph Convolution Model for Bundle Recommendation
Authors: Liu Xingtong , Yuan Man
Published: August 2023

Bundle recommendation is provided to users by combining related items into a bundle, enhancing the user's shopping experience and increase the merchant's sales revenue. Despite the success of existing solutions based on Graph Neural Networks(GNN), there are still some significant challenges: (1)It is demanding to explicitly model multiple complex associations using standard graph neural networks. (2)Numerous additional nodes and edges are introduced to approximate higher-order associations. (3)The user-bundle historical interaction data is highly sparse. In this work, we propose a Global Structural Hypergraph Convolution model for Bundle Recommendation (SHCBR) to address the above problems. Specifically, we jointly incorporate multiple complex interactions between users, items, and bundles(three entities) into a relational hypergraph without introducing additional nodes and edges. Higher-order associations are already involved in the hypergraph structure which alleviate the training burden of neural networks and the dilemma of scarce data. In addition, we design a special matrix propagation rule that captures non-pairwise complex relationships between entities. Using item nodes as links, hypergraph convolution propagation between user and bundle nodes generates the learned representations. Experimental results on two real-world datasets demonstrate that SHCBR outperforms the state-of-the-art baselines by 11.07%-25.66\% on Recall and 16.81%-33.53% on NDCG. We publicly release the codes and datasets at https://github.com/Lxtdzh/SHCBR-master/.
Identification and validation of blood miRNAs as diagnostic markers of gastric cancer
Authors: Wang Qingyu , Xu Zhouhan , Yang Xuesi , Zhao Ruiqi , Li Xueling , Li Shujie , Li Xize , Zeng Jiping
Published: August 2023

In order to provide a new direction for the diagnosis and treatment of gastric cancer, the differentially expressed blood-based miRNAs in gastric carcinoma were obtained and analyzed from the datasets GSE113486, GSE112264 and GSE113740 by the SangerBox, the miRNA - target genes prediction, GO and KEGG functional enrichment analyses with DAVID 6.8, and the STRING database with Cytoscape, respectively. The correlation between the key miRNAs expression and the prognosis and diagnostic value of gastric cancer patients were detected by survival prognosis and ROC curve. QRT-PCR was used to detect the possible key miRNAs expression in human blood species. The dataset GSE108307 which shows the miRNAs affected by H. pylori infection was analyzed by GEO2R. The expression level of CagA and the clinically used gastric cancer markers were detected in human blood species for contrast. Five key blood-based miRNAs were determined, including hsa-miR-124-3p, hsa-miR-125a-3p, hsa-miR-29b-3p, hsa-miR-4276, and hsa-miR-575.The detection in human blood species as well as the cross analysis with H. pylori infection and clinically used markers expression suggested the importance and efficacy of the specific miRNAs in the early diagnosis and monitoring of gastric carcinoma. The study identified potential novel blood miRNA biomarkers of gastric cancer by bioinformatics and human blood species detection, which may give a new possibility of the important biomarkers for the diagnosis and prognosis of gastric cancer.
Bioinformatic Analysis of Sex and Age Factors of the Expression
of the Genes Related to Dyslipidemia-based Atherosclerosis.
Authors: Guzzi Pietro Hiram , Cortese Francesca , Pedace Elisabetta , Veltri Pierangelo
Published: August 2023

Dyslipidemia (Dys) is a disease characterised by abnormally high levels of lipids in the
blood. It causes the deposits of lipids on the arterial wall leading to the insurgence of atherosclerosis,
i.e. the increased thickness of arterial walls, which finally increases the risk of cardiovascular diseases.
Dyslipidemia is a comorbidity of Type 2 Diabetes Mellitus (T2DM). A set of genes has been associated with dyslipidemia, but examining the regulation of such genes in age and sex is still an open research
field. In this study, we select from publicly available databases the genes associated with dyslipidemia
and analyse changes in the basal level of such genes by age and sex. Moreover, we also distinct
differential rewiring of the related gene association network in males and females. Our results show
that there exist a set of genes whose expression changes with age in artery tibial, artery aorta and
blood. Moreover, there exist significant differences between sex.
Effect of Microplastics Particles on the Rheological Properties of Human Saliva and Mucus
Authors: Przekop Rafał , Michalczuk Urszula , Penconek Agata , Moskal Arkadiusz
Published: August 2023

The level of air pollution by nano and microparticles raises rapidly. One of the methods of human exposure to nanoparticles is through inhalation. Indoor environments contain airborne plastic particles, primarily from synthetic textiles, leading to unintended inhalation or occupational exposure. In outdoor environments, exposure could happen through breathing in contaminated aerosols from ocean waves or airborne fertilizer particles from dried wastewater treatments. Airborne particles affect human health in various ways and they also act directly on the epithelium and its mucus layer after deposition in the mouth and respiratory system. Exposure via ingestion to microplastics present in the various environmental compartments may occur either directly or indirectly via the food chain or drinking water. The aim of the study was to determine the influence of plastic microparticles on the rheology of mucus and saliva, and thus on their functioning. The artificial mucus and saliva, as and plastic nanoparticles (namely PS – polystyrene and PE - polyethylene) were used in experiments. The rheological properties of saliva and mucus were determined with the use of an oscillatory rheometer, at various temperatures (namely 36.6 C and 40 C, what corresponds to the case of healthy and ill human) The results were compared with those obtained for pure saliva and mucus. The influence of the presence of the particles on the parameters of the constituitive viscosity equations was studied. The presence of plastic micro- and nanoparticles in the saliva and mucus may interfere with their physiological functions.
Myxoid Endometriosis: An Entity That Can Cause Confusion with Malignant Entities
Authors: Mendoza-Ramirez Saulo , Hernández-Robles Claudia Mariana , Velasco-Rueda Italú , Romero-Utrilla Alejandra , Arrecillas-Zamora Myrna Doris , Agustín-Godínez Eduardo , Morales-Jáuregui Lourdes Lucía , Ramírez-Balderrama Lázaro Ariel , Olvera-Olvera Marco Antonio , Murguia-Perez Mario
Published: August 2023

Myxoid endometriosis is a rare entity that is part of the histological changes that can occur in endometriosis. It is extremely important that the pathologist has knowledge of the histological guidelines for the morphological recognition of this entity, as well as the histochemical and immunohistochemical techniques that will support the diagnosis. Define the morphological characteristics of myxoid endometriosis. In the present work we propose diagnostic approach guidelines, as well as the main differential diagnoses with the use of special histochemical techniques and immunohistochemical reactions to recognize this entity.
The Impact of Dam Construction on Downstream Vegetation Area in Dry Areas Using Satellite Remote Sensing
Authors: Almalki Raid , Khaki Mehdi , Saco Patricia , Rodriguez Jose
Published: August 2023

The assessment of ecosystem quality and the maintenance of optimal ecosystem function requires understanding vegetation area dynamics and its relationship with climate variables. This study aims to detect vegetation area changes over a downstream dam and to understand the influence of the dam as well as climatic variables on the region’s vegetation areas. The case study is located in an arid area with an average rainfall amount of 50 to 100 mm/year. An analysis of seasonal changes in vegetation areas was conducted using the Normalized Difference Vegetation Index (NDVI), and supervised image classification was used to evaluate changes in vegetation areas using Landsat imagery. Pearson correlation and multivariate linear regression were used to assess the response of local vegetation areas to both hydrologic changes due to dam construction and climate variability. The NDVI analysis reveals a considerable vegetation decline after the dam construction in the dry season. This is primarily associated with the impoundment of the seasonal water by the dam and the increase in cropland areas due to dam irrigation. A significantly stronger correlation between vegetation changes and precipitation and temperature variations is observed before the dam construction. Furthermore, multivariant linear regression was used to evaluate the variations of equivalent water thickness (EWT), climate data, and NDVI before and after the dam construction. The results suggest that 85 percent of the variability in the mean NDVI was driven by climate variables and EWT before the dam construction. On the other hand, it was found that only 42 percent of the variations in NDVI were driven by climate variables and EWT after the dam construction for both dry and wet seasons.
Settlement and Distribution Structure Proposal of Music Royalties in Korea and Its AI-based Applications
Authors: Kim Youngmin , Kim Dong Hwan , Park Sunho , Kim YongHwa , Hong Jisoo , Hong Sunghee , Jeong Jinsoo , Lee Byounghyo , Oh Hyeonchan
Published: August 2023

Digital music is one of the most important things in market due to the music royalties’ distribution in Korea. As the music market is transformed to the digital music market such as download the music and streaming, the distribution of music royalties starting from online service provider (OSP) has come to be a highly important part for music rights holders. One of the most important issues in current music royalties’ distribution in Korea is the unfair way of music royalties due to indiscriminative repeat streaming of digital music. To prevent this, music log usage data from several OSPs was collected in day-based system, however, there was a limit to identify detailed information on the use of music in current state. This paper analyzed the structural problems and limitations of settlement of music royalties, and provides a structure in which there can be transparent settlement and distribution between users and rights holders as one of the institutional measures. We’ll also propose various AI-based applications using music log usage data. The proposed system will hopefully be used for public purposes.