bluuebunny/crossref_metadata_2025 huggingface dataset:
Microaprendizajes en el aula universitaria: uso de simulador virtual en el área de biología
Authors: Romero-Saritama José Miguel , Llorente-Cejudo Carmen , Palacios Rodríguez Antonio , Kalinhoff Carolina
Published: June 2024

El cierre físico de las instituciones educativas durante la pandemia planteó nuevos retos para los autores educativos que tuvieron que adoptar sobre la marcha nuevas herramientas virtuales para su proceso de enseñanza-aprendizaje. En este sentido, el presente trabajo analiza de forma cuantitativa el uso de un simulador virtual disponible en la web como una estrategia educativa vinculada a las prácticas de laboratorio desarrolladas durante la pandemia en la asignatura de Microscopía y Microanálisis en una universidad ecuatoriana. Siguiendo las premisas de los docentes para el desarrollo de la práctica, 30 estudiantes experimentaron el manejo del simulador y contestaron a un cuestionario ad hoc, donde se evaluó tanto el uso del simulador como las competencias académicas adquiridas. Los resultados evidencian valores altos positivos en la percepción estudiantil y se concibió al uso del simulador como una experiencia interesante e innovadora. Esto discute el uso de entornos virtuales como una alternativa académica a las disciplinas con un componente práctico.
Empowerment of Village Communities Around Forest Through Joint Community Forest Management (PHBM) in Kedungsuren Village
Authors: Saerozi Saerozi , Perdana Dian Adi , Musyafak Najahan , Susanto Dedy , Hakim Lukmanul , Jarong Koree
Published: June 2024

Community empowerment through the Joint Community Forest Management (PHBM) Program has been implemented so far by the Kendal Forest Management Unit (KPH) together with the community and has succeeded in improving the community economy in Kedungsuren Village. The aim of this study; is (1) knowing the causes of community poverty in Kedungsuren Village, (2) knowing community empowerment through Community Forest Management (PHBM). In this type of qualitative research, with a descriptive approach and case studies, the research locus in Kedungsuren Village is in the KPH Kendal forest area. Data collection using interviews, observation, and documentation. The research analysis uses qualitative description. The results of this research show that (1) the causes of poverty are poor quality of human resources, lack of agricultural land, lack of capital, agricultural products sold to intermediaries, lack of skills in managing livestock, and lots of agricultural pests. (2) Community empowerment through Joint Community Forest Management (PHBM), namely through community skills and additional business capital, entrepreneurial training for LMDH members, socialization and counseling for LMDH, community involvement in PHBM programs starting from planning to the monitoring stage and evaluation, and use of shared funds by LMDH.
The Work Ethic of The Coastal Community of Java Island in The Perspective of Islamic Theology
Authors: Kamiluddin Udin , Suryatna Yayat , Ghofur Muhammad Ikhsan
Published: June 2024

This study examines the typology of the work ethic of the people on the North Coast (PANTURA) of Java Island and the correlation between work ethic typology and economic conditions. The research uses qualitative and quantitative methods to focus on communities in Indramayu, Cirebon City, and Cirebon Regency. Results show that 86% of respondents follow the Qadariyah Theological Doctrine, 6.6% adhere to the Jabariyah Doctrine, and another 6.6% have a combined Qadariyah-Jabariyah typology. 86% of workers in the private sector align with Qadariyah, while all civil servants follow Qadariyah. A significant correlation exists between work ethic typology and income: Qadariyah adherents generally have higher monthly incomes than those following Jabariyah or combined typologies. Respondents with Jabariyah and combined typologies typically earn less than 5 million monthly rupiah. Among the 26 respondents with a Qadariyah work ethic, 14 earn more than 5 million rupiah monthly. The study concludes that theological doctrines significantly influence work ethic and economic conditions in Java's coastal areas.
Salutation and Role-Playing: Spiritual and Psychological Synergy to Strengthen the Confidence of Islamic Boarding School Student
Authors: Ningsih Yusria , Riyadi Abdul Kadir , Madihie Amalia
Published: June 2024

This study aims to investigate the effectiveness of combining sholawat therapy with role-playing techniques to enhance the self-confidence of santri at Darul Arqom Islamic Boarding School Surabaya. Santri, in this context, refers to students in Islamic boarding schools. A qualitative descriptive research method involves data collection through observation, interviews, and document analysis. The findings revealed that sholawat therapy with role-playing techniques had a significant positive impact on Santri's self-confidence. Santri, who participated in this program, experienced increased self-confidence, more active involvement in religious activities, and positive changes in their social behavior. This study suggests that sholawat therapy with role-playing techniques is an effective approach to strengthening Santri's self-confidence in the context of religious education. It provides a foundation for further developing this combination in clinical practice and religious education.
Digitalization of companies as a factor of their adaptation to COVID and sanctions shocks
Authors: Kuzyk Mikhail G. ,   Centre for Industrial Policy Studies, HSE University, Simachev Yury V. , Fedyunina Anna A. , Sergeeva Kira P. ,   Centre for Industrial Policy Studies, HSE University,   Centre for Industrial Policy Studies, HSE University,   Centre for Industrial Policy Studies, HSE University
Published: July 2024

Goal: to investigate the relationship between firms' digitalization and their success in adapting to non-economic shocks in 2020 and 2022. Methodology: econometric analysis of the results of a sample questionnaire survey of 1 800 Russian manufacturing companies conducted in 2022. Findings: significant differences in the factors of successful overcoming of the COVID-19 and sanctions shocks by companies were found. A positive correlation between the digitalization of companies and the dynamics of their revenue and headcount in 2020 was revealed. It is shown that the digitalization of management was a significant factor for companies to better pass the COVID crisis. In addition, the use of digital technologies in production played a positive role in preserving employment in 2020. In 2022, digital technologies did not provide a significant contribution to firm dynamics, although progressive firms that typically use digital technologies adapted better to sanctions pressure. It is also found that the COVID crisis hit the smallest firms the hardest, while the shock of 2022 affected large companies and importing firms more strongly. Under the current sanctions pressure the demand of the state and large and mediumsized Russian business plays a positive role, which may indicate the growing importance of public procurement and import substitution. Originality and contribution of the authors: the study expands empirical knowledge on the role of digital technologies in overcoming noneconomic shocks by companies. Special attention is paid to the digitalization of specific types of business processes.
Quaternization-based graft modification of straw fibers for conditioning the sludge dewatering performance
Authors: Zhang Qingfang , Zhao Yanbin , Yang Qiyong , Xu Binjie , Zhang Xinhua , Xiong Houfeng , Zhou Han , Xiao Ruimin
Published: July 2024

Extracellular polymeric substances (EPS) are a critical influencing factor in sludge dewatering. Disrupting such EPS contributes to the release of bound water in sludge, enhancing the sludge dewatering performance. In This study, quaternized straw fibers that are destructive to the EPS structure and components in active sludge were prepared useing heterogeneous free radical graft polymerization. Straw fibers, dimethyl diallyl ammonium chloride (DMDAAC), ammonium persulfate (APS), and acrylamide (AM) were taken as the substrate, grafting monomer, catalyst, and cross-linking agent, respectively.The optimal processing conditions determined for the DMDAAC-based quaternization and graft modification of straw fibers were as follows: reaction temperature of 60 °C, reaction time of 5 h, 0.100 g of catalyst APS dosage per gram of straw, and 3.000 ml of DMDAAC dosage per gram of straw. The optimal processing conditions yielded 1.335 g of modified straw fibers per gram of straw, 33.67% grafting rate, and 31.70% substitution of the quaternary ammonium groups. The capillary suction time (CST) was conditioned from 243.3 ± 22.6 s in the original sludge to 134.5 ± 34.45 s. The specific resistance to filtration (SRF) was reduced from 8.82 ± 0.51 × 1012 m/kg in the original sludge to 4.59 ± 0.23 × 1012 m/kg.
La entrevista como abordaje etnográfico en educación: del trabajo de campo al descubrimiento y el dato
Authors: Shapiro Judith
Published: July 2024

El presente artículo busca acercar algunas reflexiones en torno a las entrevistas como metodología de investigación en etnografía de la educación, sobre todo al tratar temas históricos de los que no se puede hacer observación directa. Se trabajará en base a la experiencia de campo realizada para una investigación acerca de los sentidos construidos por estudiantes universitarios frente a la reforma de la educación superior argentina en la década de 1990. Se realizaron dos entrevistas semi-estructuradas a cinco personas que habían sido estudiantes universitaries durante los noventa. Reconociendo que el trabajo de campo muchas veces puede ser abrumador, la pregunta acerca de cuáles son los descubrimientos etnográficos en una investigación permite volver a poner el foco en lo más relevante. De ahí se desprenden dos movimientos metodológicos: el primero indaga y define qué es un descubrimiento etnográfico, y el segundo guía el recorrido de elaboración hasta llegar a lo que se puede considerar un dato. Para definir un descubrimiento, se propone repensar el lugar de les investigadores como mediadores en el proceso de intercambio de sentidos en el contexto de investigación, y luego se considera el proceso de construcción del dato como un diálogo entre diversos sentidos y realidades. De todo ello resulta el reconocimiento de las notas de campo etnográficas como un género discursivo en sí mismo, que contiene dimensiones comunicativas que permiten reconocer el vínculo que se genera entre les investigadores y los sujetos del campo. Se resalta que, del lado de la investigación, es necesario conservar una constante vigilancia epistemológica para no dar por sentados los sentidos hallados, sino reconocerlos como construcciones in situ.
Searching Heterocyclic Scaffolds Used to Treat Alzheimer’s Disease: A
Review
Authors: Kale Mayura A , Faisal Mohammed
Published: July 2024

It is a known fact that Alzheimer's disease causes degeneration of the central nervous
system, which progresses and causes memory loss as well as loss of cognition. For many years,
extensive research has been undertaken to find out newer possibilities to fight this disease at a
molecular level along with many long-standing and expensive clinical trials. Many scientific
research programs have either been discarded or unsuccessful. However, the research has not
stopped and in the process, many heterocyclic scaffolds have been tried to build up novel drug
molecules to combat this disease. A literature survey reveals that many heterocycles have been
explored and were found to be very useful in treating many neurodegenerative disorders, including
Alzheimer’s disease, Parkinsonism and a few more. This review explains the journey
and highlights the various strategies to develop new anti-Alzheimer drug candidates. It is a concise
and rigorous literature excerpt involving research findings on heterocyclic scaffolds for
treating this disease.
Role of Milk-Derived Antimicrobial Peptides and their Future Perspectives in Pharmaceutical/ Dairy Industries
Authors: Krishnaswami Venkateshwaran , Muruganantham Selvakumar , Raja Jacob , K Sripathi Subhashini
Published: July 2024

Milk is a good source of bioactive peptides of high nutritive/ pharmaceutical value. In
recent decades, the curiosity about bioactive milk peptides has been increasing because of their
positive impact on physiological and metabolic functions in human health. A variety of naturally
acquired bioactive peptides have been found in fermented dairy products like sour milk and cheese.
Initially, these bioactive peptides are found as inactive forms within the precursor protein sequence
and can be released in different ways. They can be generated by gastrointestinal digestion of milk,
fermentation of milk with proteolytic microorganisms, or hydrolysis via proteolytic enzymes.
Once they are released from the precursor protein sequence, they influence body functions and
human health. Peptides derived from cow milk exert multifunctional properties, including antimicrobial,
antidiabetic, antihypertensive, anti-inflammatory, immune-modulatory, antioxidant activities,
etc. Bioactive antimicrobial peptides are observed in the Cow milk proteins. The cow milk
peptides afford the non-immune-based defense and control for various microbial infections. These
activities depend upon their amino acid composition/ sequence. Potential pathogens are constantly
exposed to mucosal surfaces (lungs and small intestine). The risk of chronic disease was
inhibited by antimicrobial peptides, which may afford natural immune protection with the avoidance
of microbial resistance. In this regimen, the present review summarizes the milk-derived antimicrobial
peptides obtained from casein/ whey protein, along with their future perspectives in the
pharmaceutical and dairy industries
Autism and its social impact
Authors: Rodríguez-Saltos Elisa Rafaela , Yenchong-Meza Werme Esaud , Ponce-Solorzano Maria Julieta
Published: June 2024

The objective that is intended to be achieved with this article is to raise awareness of Autism Spectrum Disorder linked to the various areas where the individual with ASD is presented as the main actor. One of the main characteristics that a person with Autism Spectrum Disorder has is the difficulty in communicating with other people, it affects the neurodevelopment of the person, its first symptoms begin in the first years of life, therefore the communication relationship and emotional that begins with the family is one of the main ones, here the confidence to relate to the outside world, such as school, is strengthened; The child begins to bond with people of the same age, which can be a viable strategy for the development of interpersonal intelligence. Then there is the social area, which aims to achieve good communication relationships with others, and finally, there is the world. work, where the subject is in the adult stage achieving self-sufficiency and empowerment to break barriers in their professional life.
The Impact of Digital Technology on the Role of Librarians in Higher Education (A Challenge, Opportunity, and Transformation)
Authors: Nur Subchan
Published: July 2024

This research aims to understand the impact of the shift to digital technology on the work of university librarians, identify strategies to stay relevant in the digital age, and improve library services. This study uses a qualitative approach with a case study method, collects data through interviews with university librarians who experience changes due to digital technology, and analyzes related documents and literature to identify their patterns, challenges, and strategies in dealing with these changes. This research showed that the shift to digital technology has had a significant impact on the role of university librarians. Librarians must now manage electronic resources and develop new skills, such as information technology, metadata management, and digital preservation. They also need to be able to navigate the complex digital information landscape, promote electronic resources, and collaborate with users in the development of digital resources. In addition to technical ability, librarians must be creative and innovative, willing to experiment with new approaches and technologies, and look at problem-solving options. Innovation is key to staying relevant in the digital age. Previous studies have also highlighted the importance of collaboration with users and a focus on community needs as important elements in developing effective library services. This research reveals that the shift to digital technology has significantly changed the role of university librarians. They must develop in technology skills, collaborate with users, and be innovative in facing digital challenges. The ability to manage, promote electronic resources, and understand community needs is important in maintaining the relevance of librarians in the digital age.
Discovery of Pleurotus cystidiosus (Agaricales, Pleurotaceae) in the north of Mexico
Authors: Hermández-Navarro Eduardo , López-Peña Damián , Lizárraga Escobar Marcos
Published: July 2024

Background and Aims: Some species of Pleurotus form anamorphs that produce coremia and arthrospores, which are classified in the subgenus Coremiopleurotus and are morphologically very similar. In Mexico, seven species of the genus are known; however, only P. smithii, described from Mexico City, is known to form coremia. Recent collections of Pleurotus from Chihuahua, Mexico, showed distinct characteristics from the known species for the country, whose morphological and molecular characterization allowed us to identify P. cystidiosus in Mexico. The objective of this work was to document the presence of P. cystidiosus in Mexico and provide a detailed description of the specimens found in the country.
Methods: The material was collected in Ciudad Juárez, Chihuahua, Mexico. Specimens were characterized macro- and microscopically through in situ photographs, polyfocal, and light microscopy. Morphological identification was performed using specialized literature. DNA extraction was carried out following a 3% CTAB protocol. The ITS region was amplified using the primer pairs ITS5/ITS4. Phylogenetic analyses were conducted using Maximum Likelihood and Bayesian Inference.
Key results: Pleurotus cystidiosus, a species previously unreported in Mexico, is morphologically and taxonomically described, confirmed with barcode sequences. The species is distinguished by the presence of abundant clavate to pyriform pleurocystidia and subglobose cheilocystidia in the teleomorph, as well as the formation of coremia with a white stipe, black head, and segments of arthrospores up to 17-25 × 5-7.5 µm in the anamorph.
Conclusions: The presence of P. cystidiosus in the north of Mexico is confirmed. With this study, the number of known Pleurotus species for Mexico increases to eight.
Artificial intelligence and project management maturity: A study of selected project-based organizations in Pakistan
Authors:   Lahore School of Professional Studies, The University of Lahore, Lahore, Pakistan, Tariq Burhana , Ali Amanat ,   Lahore School of Professional Studies, The University of Lahore, Lahore, Pakistan, Khattak Muhammad Sajid ,   Planning and Development Directorate, Quaid-i-Azam University, Islamabad, Pakistan, Arfeen Muhammad Irfanullah ,   Quaid-i-Azam School of Management Sciences, Quaid-i-Azam University, Islamabad, Pakistan, Chaudhary Muhammad Azam I. ,   Department of Health Informatics, Northwest Integrated Health, Tacoma, USA, Iqbal Faisal ,   Dera Ghazi Khan Waste Management Company, Punjab, Pakistan
Published: June 2024

Artificial intelligence (AI) is significantly impacting modern project management (PM) nowadays, especially as it begins to be integrated into business applications. This study focused on evaluating the readiness for AI implementation and the maturity level of PM in selected project-oriented organizations in Pakistan. Data from 12 such organizations were gathered through focus groups to examine the status of AI readiness and PM maturity and to explore their association. The methods used included exploratory data analysis and research on extreme cases. The findings indicated that AI readiness was relatively high in areas of governance and legal aspects but lower in solution development. Conversely, PM maturity was found to be higher in PM but less developed in program and portfolio management. Analysis of extreme cases suggested a positive relationship between AI readiness and PM maturity, supporting the idea that AI can enhance PM. These findings are crucial both for theoretical understanding and practical application.
On the diffusive model of C60 fullerene clusterization in liquids
Authors: Elnikova L. V. , Shevchenko V. G. , Kuzmenko A. P.
Published: July 2024

Purpose of research. The purpose of the study is to explain the mechanisms of clustering of fullerene molecules in liquid media observed using various structural nuclear -physical methods, as well as the interpretation of experimental data within the framework of a microscopic diffusion model.

   Methods. The article gives a brief overview of the results of positron annihilation spectroscopy, small-angle neutron scattering, translucent electron microscopy, with which the geometric parameters of fullerene clusters in solutions were established. The theoretical method of research is the microscopic diffusion model “Limited diffusion aggregation”, which describes the kinetic processes of clusterization.

   Results. The diffusion limited aggregation model displays adequately the mechanism of formation of C60 molecules in the form of fractal units in the volume of fluid, observed in experiments on positron annihilation spectroscopy and small-angle neutron scattering. The structural indicators of aggregate fullerene particles in carbon disulfide, o-Xylene, toluene, water and other solvents are analyzed. The properties of various diffusion models (the reaction limited aggregation model and the diffusion limited aggregation model) are considered and their combination in relation to the assessmentsof the kinetics of fullerene aggregation in solutions. A quantitative comparison of the results of the discussed models was carried out using the example of carbon disulfide.

   Conclusion. The diffusion microscopic models adequately describe the phenomenon of fullerene aggregation in polar and non-polar solvents, which are recorded by various nuclear methods (positron annihilating spectroscopy and small-angle neutron scattering), the most reliable is the diffusion limited aggregation model, more than that, it is the basis of a numerical definition of structural structures parameters of units. Compared to neutron scattering, with the annihilation of positrons, in the aggregation of fullerene the [Ps–C60] molecular complexes participate in the clusterization, but this does not affect the change in the size of the cluster and the reliability of the results.
Structure and properties of powders obtained by electrodispersion of pure tungsten metal waste in distilled water
Authors: Ageeva E. V. , Ulitin D. A. , Korolev M. S. , Ageeva A. E.
Published: July 2024

Purpose. Investigation of the composition, structure and properties of powder materials obtained by electrodispersion of tungsten waste of the VA brand in an oxygen–containing medium - distilled water.

   Methods. To determine the composition, structure and properties of powder materials, samples of powders obtained from waste tungsten of the VA brand were studied. The powder material was obtained by electroerosive dispersion in distilled water. Microanalysis of powder particles was carried out using a scanning electron microscope, analysis of the size distribution of powder particles was obtained using a particle size analyzer, X-ray spectral microanalysis of powder particles was carried out using an energy dispersive X-ray analyzer integrated into a scanning electron microscope, analysis of the phase composition of powder particles was carried out using X-ray diffraction on a diffractometer.

   Results. During the study, it was revealed that the shape of the particles obtained from powdered tungsten materials is spherical and elliptical, and agglomerates of smaller particles are also marked on magnification. Oxygen and tungsten are present in the composition of powder materials, while there are no joint structural components. The phases of pure tungsten in α and β modifications are noted in the phase composition. It follows from the analysis of the granulometric histogram that the particle size spread varies in the range of 0.092–62.59 microns, while the average particle diameterwas 5.73 microns.

   Conclusion. The obtained research results can be used to develop a new heavy pseudo-alloy using metal waste of expensive raw materials by the method of electroerosive dispersion with subsequent improvement and optimization of the composition and structure of the alloy.
The Combination of Methionine Restriction and Docetaxel Synergistically Arrests Androgen-independent Prostate Cancer But Not Normal Cells
Authors: MIZUTA KOHEI , MORI RYOSUKE , HAN QINGHONG , MORINAGA SEI , SATO MOTOKAZU , KANG BYUNG MO , BOUVET MICHAEL , TOME YASUNORI , NISHIDA KOTARO , HOFFMAN ROBERT M.
Published: July 2024

Background/Aim: Androgen-independent prostate cancer (AIPC) is resistant to androgen-depletion therapy and is a recalcitrant disease. Docetaxel is the first-line treatment for AIPC, but has limited efficacy and severe side-effects. All cancers are methionine-addicted, which is termed the Hoffman effect. Recombinant methioninase (rMETase) targets methionine addiction. The purpose of the present study was to determine if the combination of docetaxel and rMETase is effective for AIPC. Materials and Methods: The half-maximal inhibitory concentrations (IC50) of docetaxel and rMETase alone were determined for the human AIPC cell line PC-3 and Hs27 normal human fibroblasts in vitro. The synergistic efficacy for PC-3 and Hs27 using the combination of docetaxel and rMETase at their IC50s for PC-3 was determined. Results: The IC50 of docetaxel for PC-3 and for Hs27 was 0.72 nM and 0.94 nM, respectively. The IC50 of rMETase for PC-3 and for Hs27 was 0.67 U/ml and 0.76 U/ml, respectively. The combination of docetaxel and rMETase was synergistic for PC-3 but not Hs27 cells. Conclusion: The combination of a relatively low concentration of docetaxel and rMETase was synergistic and effective for AIPC. The present results also suggest that the effective concentration of docetaxel can be reduced by using rMETase, which may reduce toxicity. The present results also suggest the future clinical potential of the combination of docetaxel and rMETase for AIPC.
Laryngeal Preservation Rate and Salvage Therapy Following Initial Recurrence in a Real-world Setting After Definitive Radiation Therapy in Patients With Locally Advanced Laryngeal Squamous Cell Carcinoma
Authors: KATANO ATSUTO , MAEMURA TAKESHI , MINAMITANI MASANARI , OHIRA SHINGO , YAMASHITA HIDEOMI
Published: July 2024

Background/Aim: The larynx plays a pivotal role in vocalization and airway protection, and laryngeal cancer manifests through various symptoms. Contemporary strategies focus on laryngeal preservation, particularly through non-surgical modality therapies that utilize radiotherapy. The aim of this study was to assess the laryngeal preservation rate after definitive radiation therapy in patients with locally advanced laryngeal squamous cell carcinoma and investigate salvage therapy subsequent to the initial recurrence in a real-world context. Patients and Methods: Analysis included a total of 40 patients with locally advanced laryngeal squamous cell carcinoma who were treated with definitive radiotherapy in the University of Tokyo Hospital. Treatment involved external beam radiotherapy (70 Gy in 35 fractions) with elective nodal irradiation. The main study outcomes were assessment of survival, overall survival, local control, and the factors influencing laryngeal preservation. Results: The patients exhibited a median age of 64.5 years, and 80% of them were men. Chemotherapy was administered to 82.5% of the patients. The 3-year overall survival, progression-free, and laryngeal preservation survival rates were 86.3%, 66.8%, and 78.4%, respectively. Univariate and multivariate analyses identified chemotherapy to be significantly associated with favorable laryngeal preservation survival (p<0.001). Conclusion: Definitive radiotherapy results in favorable outcomes for laryngeal preservation in locally advanced laryngeal squamous cell carcinoma. This study emphasizes the importance of chemotherapy in comprehensive patient management. Nevertheless, larger prospective studies are crucial to validate and optimize therapeutic approaches for this condition.
YAPAY ZEKA KULLANILARAK TREN TEKERLEKLERİNİN YORULMA ÖZELLİKLERİNİN VEKİL MODELLENMESİ
Authors: Mahouti Mehran , Komek Mehmet Sinan , Yılmaz Suat
Published: June 2024

Sonlu elemanlar yöntemi (FEM), tren tekerlekleri gibi karmaşık yapıların analiz edilmesi ve tasarlanması için mühendislikte hayati bir araçtır. Tren tekerlekleri, işletme ömürleri boyunca karşılaştıkları aşırı ve değişken yükler nedeniyle yorulmaya maruz kalmaktadır ve bu durum, ömür süresi ve güvenlik üzerindeki etkileri nedeniyle tren tekerleği tasarımında kritik bir endişe kaynağıdır. Ancak, özellikle tren tekerlekleri gibi karmaşık geometrilere sahip büyük ölçekli yapıların modellenmesinde FEM'in geniş hesaplama ihtiyaçları önemli zorluklar sunmaktadır. Doğru yorgunluk analizi için gereken detaylı modelleme, genellikle büyük hesaplama yükleri ve uzun zaman dilimleri ile sonuçlanmakta ve bu durum, hızlı karar verilmesi gereken durumlarda daha az uygulanabilir bir seçenek haline gelmektedir. Bu sınırlamaları ele almak için, Yapay Zeka (AI), yenilikçi bir çözüm olarak ortaya çıkmıştır. FEM simülasyonlarından elde edilen veri setleri üzerinde eğitilen YZ modelleri, geleneksel hesaplama maliyeti ve zamanının bir kısmında yorgunluk ömrünü tahmin ederek etkin bir alternatif sunmaktadır. Bu vekil modeller, mühendislik tasarım optimizasyonu süreçleri için gerekli olan hızlı ve doğru tahmini sağlamaktadır. Bu çalışmada YZ tabanlı vekil modelleme yaklaşımı ile tren tekerlekleri optimizasyon problemini geleneksel FEM yaklaşımına kıyas ile nerdeyse %90 oranında hızlandırma başarısına erişilmiştir.
ÇÖLYAK HASTALARI İÇİN ISPARTA GÜLÜ (ROSA DAMASCENA MILL.) İLE ZENGİNLEŞTİRİLMİŞ GLUTENSİZ DONDURMA KÜLAHI GELİŞTİRİLMESİ
Authors: Gül Elif Ece , Uğurel Biçici Arzu , Gül Hülya , Acun Sultan
Published: June 2024

Dünyada en yaygın görülen genetik temelli gıda intoleransı olan çölyak hastalığı, buğday, arpa, çavdar gibi tahıllarda bulunan glutene karşı aşırı duyarlılığa bağlı olarak gelişen otoimmün bir hastalıktır ve tek tedavisi, gluten içeren yiyeceklerin ömür boyu diyetten çıkarılmasıdır. Bu çalışmada; özellikle çölyak hastası çocuklar için Isparta gülü yaprağı unu (GYU) ile zenginleştirilmiş teknolojik ve duyusal bakımdan kabul edilebilir kalitede glutensiz dondurma külahı geliştirilmesi amaçlanmıştır. Araştırma sonucunda GYU ile zenginleştirilmiş glutensiz dondurma külahlarının GYU içermeyen glutenli ve glutensiz dondurma külahlarına göre mineral madde, toplam diyet lif, toplam fenolik madde ve antioksidan aktivite açısından çok daha yüksek bir içeriğe sahip olduğu belirlenmiştir. Bununla birlikte GYU %10 oranında glutensiz un karışımı ile ikame edildiğinde teknolojik ve duyusal olarak kabul edilebilir nitelikte bir glutensiz dondurma külahı üretiminin mümkün olabildiği sonucuna ulaşılmıştır. Elde edilen bulgular Isparta GYU'nun glutensiz gofret ve dondurma külahının yanı sıra glutensiz diğer gıda ürünlerinin besin içeriğinin zenginleştirilmesi amacıyla da kullanılabileceğini göstermiştir.
Design and Psychometric Evaluation of Nurses’ Mobile Health Device Acceptance Scale (NMHDA-Scale): Application of the Expectation-Confirmation Theory
Authors: Mirabootalebi Narjes , Meidani Zahra , Akbari Hossein , Rangraz Jeddi Fatemeh , Tagharrobi Zahra , Swoboda Walter , Holl Felix
Published: July 2024

Background

The use of mobile tools in nursing care is indispensable. Given the importance of nurses’ acceptance of these tools in delivering effective care, this issue requires greater attention.

Objective

This study aims to design the Mobile Health Tool Acceptance Scale for Nurses based on the Expectation-Confirmation Theory and to evaluate it psychometrically.

Methods

Using a Waltz-based approach grounded in existing tools and the constructs of the Expectation-Confirmation Theory, the initial version of the scale was designed and evaluated for face and content validity. Construct validity was examined through exploratory factor analysis, concurrent validity, and known-group comparison. Reliability was assessed using measures of internal consistency and stability.

Results

The initial version of the scale consisted of 33 items. During the qualitative and quantitative content validity stage, 1 item was added and 1 item was removed. Exploratory factor analysis, retaining 33 items, identified 5 factors that explained 70.53% of the variance. A significant positive correlation was found between the scores of the designed tool and nurses’ attitudes toward using mobile-based apps in nursing care (r=0.655, P<.001). The intraclass correlation coefficient, Cronbach α, and ω coefficient were 0.938, 0.953, and 0.907, respectively.

Conclusions

The 33-item scale developed is a valid and reliable instrument for measuring nurses’ acceptance of mobile health tools.
Quality of Chronic Obstructive Pulmonary Disease Information on the Chinese Internet: Website Evaluation Study
Authors: Wang Qinqin , Liu Lingjun , Li Hong , Zhang Qiao , Ma Qianli
Published: July 2024

Background

The development of internet technology has greatly increased the ability of patients with chronic obstructive pulmonary disease (COPD) to obtain health information, giving patients more initiative in the patient-physician decision-making process. However, concerns about the quality of website health information will affect the enthusiasm of patients’ website search behavior. Therefore, it is necessary to evaluate the current situation of Chinese internet information on COPD.

Objective

This study aims to evaluate the quality of COPD treatment information on the Chinese internet.

Methods

Using the standard disease name “慢性阻塞性肺疾病” (“chronic obstructive pulmonary disease” in Chinese) and the commonly used public search terms “慢阻肺” (“COPD”) and “肺气肿” (“emphysema”) combined with the keyword “治疗” (“treatment”), we searched the PC client web page of Baidu, Sogou, and 360 search engines and screened the first 50 links of the website from July to August 2021. The language was restricted to Chinese for all the websites. The DISCERN tool was used to evaluate the websites.

Results

A total of 96 websites were included and analyzed. The mean overall DISCERN score for all websites was 30.4 (SD 10.3; range 17.3-58.7; low quality), no website reached the maximum DISCERN score of 75, and the mean score for each item was 2.0 (SD 0.7; range 1.2-3.9). There were significant differences in mean DISCERN scores between terms, with “chronic obstructive pulmonary disease” having the highest mean score.

Conclusions

The quality of COPD information on the Chinese internet is poor, which is mainly reflected in the low reliability and relevance of COPD treatment information, which can easily lead consumers to make inappropriate treatment choices. The term “chronic obstructive pulmonary disease” has the highest DISCERN score among commonly used disease search terms. It is recommended that consumers use standard disease names when searching for website information, as the information obtained is relatively reliable.
GASTRORETENTIVE EFFERVESCENT FLOATING TABLETS (GREFT) OF DRUGS ACTING ON CARDIOVASCULAR DISEASES
Authors: MAJEE SUTAPA BISWAS , MISHRA TRISHA , GUPTI SOUVIK
Published: July 2024

Incidences of Cardio Vascular Diseases (CVDs) are increasing in an alarming proportion in India. Conventional oral dosage forms cannot be retained in the stomach for long owing to gastric emptying. Moreover, drugs which are commonly employed in management of chronic CVDs either have reduced solubility at alkaline pH, undergo colonic degradation, exhibit site-specific absorption or varying bioavailability with combination therapy. Gastro-retentive drug delivery systems (GRDDS) are designed to overcome these challenges. Since 2006, Food and Drug Administration has approved only few GRDDS for treating CVDs. The aim of the present review is to summarize the outcomes of research carried on GRRDS with drugs for CVDs since last 15 y and comprehensive analysis of limitations of such studies due to which no product has been approved or commercialized in over last 18 y. Literature survey includes single unit, multi-particulate, monolayer and bilayer dosage forms with or without effervescence-inducing agents and made of natural and/or synthetic polymers like hydroxypropylmethyl cellulose, natural gums etc. Efforts have been made to compile in vitro buoyancy data such as floating lag time, total floating time, swelling index, release profile and release kinetics. Among various studies reported on monolayer and bilayer Gastro-Retentive Effervescent Floating Tablets, only 3 involved bioavailability studies in human volunteers. Toxicity studies in animals or stability studies are totally lacking. Observation with floating-type multi-particulate GRDDS is more disappointing. lack of safety, efficacy data, stability data, in vivo imaging studies and in vitro-in vivo correlation data might be actually responsible for lack of commercialization of any GRDDS for drugs acting on CVDs in 21st century.
ADAPTATION OF THE FEEDBACK TRANSFER FUNCTION FOR OSICILATION BASED TESTING OF SECOND-ORDER ACTIVE RC FILTERS
Authors: Mirković Dejan , Milić Miljana , Stanojlović Mirković Milena
Published: July 2024

This paper, explores possible solutions for the feedback transfer functions applied in active RC filters for oscillation-based testing (OBT). Three types of filter transfer functions, namely low-pass (LP), high-pass (HP) and band-pass (BP) are examined. Active filters are realized with the realistic operational amplifier model targeting the 180nm CMOS technology. To confirm the theoretical insights, three realizations of LP, HP, BP second-order filterers with proposed feedbacks are designed and simulated. One of the solutions, namely the BP filter, is further examined by inserting defects in the circuit. Based on the time domain simulations, the key parameters are extracted from the oscillating filter’s output signal. The fault dictionary has been created and appropriate classification of the defects is performed.
A Comprehensive Economic Analysis of Tobacco Farming Potential in Grobogan Regency, Central Java
Authors: Setiartiti Lilies , Setyawati Dewanti Diah
Published: July 2024

This study aims to investigate the planning for the Tobacco Products Industrial Area (KIHT) development in Grobogan Regency, Central Java, based on economic analysis. KIHT is an area where the activities of the tobacco products industry are concentrated, equipped with infrastructure, facilities, and supporting facilities for the tobacco products industry. The study was designed with a survey approach, in-depth interview, and focus group discussion (FGD) with 100 key informants to obtain facts from the existing phenomena and find information factually. The number of key informants is based on the number all of tobacco numbers in Grobogan regency. The study, therefore, analyzes tobacco competitiveness, labor absorption, product market, and macroeconomic analysis. To sharpen the analysis, the study was supported with a questionnaire instrument to see how far tobacco farmers were prepared in KIHT development. Empirically, the results showed that tobacco farming absorbed 150 HOK/ha per season, greater than corn farming which only absorbed 52 HOK per season per ha and rice farming which absorbed 87 HOK per season per ha. It had high competitiveness with the oligopsony market structure. In addition, the market for tobacco products was experiencing a significant upward trend, and it is in accordance with the Cobweb Theorem law that the behavior of farmers will try to increase the planting area when there is a previous price increase. From the potential of tobacco products, Grobogan Regency received an excise duty of IDR 14.87 billion or 2% of the total excise duty of Central Java Province. This revenue-sharing fund will increase the regional fiscal capacity.
Balancing Act: Humanitarian Governance and Migration Dynamics at the U.S.-Mexico Border.
Authors: Ramos Garcia Jose Maria , Ramos Valencia Jimmy Emmanuel
Published: June 2024

The article examines the challenges and opportunities for humanitarian governance in the Cali-Baja border region, focusing on migration between Tijuana and San Diego. Based on a focus group entitled "Vision, Challenges and Proposals for the Cali-Baja Border Region," held on November 22, 2023, the study brings together expert perspectives on regional dynamics, problems, and potential solutions. It highlights that the region is experiencing unprecedented human mobility, influenced by Biden administration policies such as humanitarian visas and Temporary Protected Status for Venezuelans, marking a contrast with the previous administration. The analysis underscores the importance of effective coordination among diverse actors to manage irregular human mobility. However, obstacles are faced in coherence and effectiveness in communication and collaboration, resulting in fragmented humanitarian responses. Challenges include limited shelter capacity and human rights protection, necessitating greater cooperation between governmental and non-governmental organizations. The lack of clear leadership and a shared rights agenda among actors has led to divergent approaches.
Migrantes haitianos en Tijuana.Surgimiento y consolidación de la primera comunidad afrodescendiente en el norte de México
Authors: Rentería Pedraza Victor Hugo , Albañez Rodríguez Marlenny , Rocha David
Published: June 2024

El objetivo de la investigación  fue determinar si los migrantes haitianos que arribaron a Tijuana desde 2016, van formando y consolidando la primera comunidad afrodescendiente en el norte de México; para el efecto se diseñó e implementó una encuesta, así como entrevistas semiestructuradas, encaminadas a captar información respecto al arraigo y a la integración con la comunidad local, medidas a partir de la capacidad para integrarse social y laboralmente, el ejercicio de la cultura propia y la incorporación de elementos de la cultura local, así como la satisfacción con el empleo, el salario y la capacidad e intención de adquirir bienes muebles e inmuebles. El estudio concluye que existen elementos que corroboran la formación de la comunidad haitiana y así la primera comunidad afrodescendiente en el norte de México, enriqueciendo la diversidad nacional e internacional, en Tijuana.
Canadian Cannabis Industry and Social Responsibility: The Case of Canopy Growth
Authors: Díaz Mendiburo Aaraón
Published: June 2024

Through the ethnographic research developed primarily in the city of Smiths Falls, Ontario and desk review that included the consultation of digital platforms and the problematization of the concept of social responsibility, the objective is to reflect on the relationship between the corporate discourse of Canopy Growth and its social responsibility practices. The article is made up of different sections; first, it reflects on the incipient literature and its contradictions regarding cannabis through the lenses of various disciplines, as well as on the historical development of the concept of corporate social responsibility within capitalism, subsequently it identifies narratives regarding social responsibility promoted by Canopy Growth in its press releases and other digital inputs and some counter-narratives issued by other stakeholders. Finally, the narratives of members of the interest groups are presented, giving prominence to former Canopy Growth workers who, share their first-hand experiences in the corporation. The conclusions demonstrate the multiple inconsistencies that Canopy Growth embodies when raising the concept of social responsibility in its media discourses. These were evidenced by personnel who worked for the corporation in the city of Smiths Falls, Ontario. Knowing the modus operandi of a leading corporation in the cannabis industry gives us the tools that are necessary to envision its potential actions in Mexico given that Canopy Growth has shown an interest in expanding into our territory for several years.
¿Por qué debo bajar de peso si tengo diabetes o hipertensión?
Authors: González-Ortiz José A. , González-Alvarado Félix , Pérez-Aguilar Antonio de Jesús
Published: June 2024

Comunicación con el paciente
Factores asociados al rendimiento académico en estudiantes universitarios de Latinoamérica en 2023
Authors: Real-Delor Raúl Emilio , Guevara Tirado Alberto , Morales Ojeda Ismael Antonio , Chibas Muñóz Eduardo Enrique , Cañete Cáceres Elena Denice , Carballo Almeida María José , Flor Lugo Dalba Noemí , Noldin Villasanti Ana Elisa , Pereira Salles Vitor , Sanabria Cañete Néstor Fabián , Alvarenga Ferreira María Eugenia , Ríos Pagnussatt Matheus , Zaracho Miranda Araceli , González Vera Guillermo Rafael
Published: June 2024

Introducción: El rendimiento académico de los estudiantes universitarios puede estar influenciado por diversos factores, como el apoyo que reciben los mismos de sus familias.
Objetivo: Determinar los factores asociados a la percepción del rendimiento académico en estudiantes universitarios de Latinoamérica en 2023.
Método: Se aplicó un diseño de corte transversal. Se incluyó a estudiantes de diversas carreras universitarias que aceptaban completar un cuestionario en línea difundido por redes sociales en Paraguay, Perú, Chile y Cuba. El cuestionario midió datos demográficos, la percepción de rendimiento académico y el apoyo familiar. Se excluyeron los cuestionarios incompletos. Se aplicó estadística descriptiva y analítica. El estudio fue aprobado por el Comité de Ética.
Resultados: Fueron incluidos 500 universitarios, la mayoría de Paraguay (53.4%). Predominó el sexo femenino (75.4%). Las carreras más frecuentes eran del área de la salud (94.6%). El 91.4% asistía a universidades privadas y 72.4% no disponía de ingresos económicos propios. Los estudiantes percibieron buen rendimiento académico en 38.8% y apoyo familiar en 40%. El mal rendimiento académico se correlacionó significativamente con la disfunción familiar (p < 0.001).
Conclusiones: El apoyo familiar fue un factor de buen rendimiento académico en los estudiantes universitarios. Se recomienda explorar periódicamente la funcionalidad familiar para apoyar a los estudiantes que refieran falta de esta.
Sobre Viviana Mejía Cañedo, Fall by the Way. Legislación migratoria e instituciones psiquiátricas de California ante los enfermos mentales de origen mexicano, 1855-1942
Authors: Velasco Ortiz Laura
Published: June 2024

Reseña del libro de Viviana Mejía Cañedo, Fall by the Way. Legislación migratoria e instituciones psiquiátricas de California ante los enfermos mentales de origen mexicano, 1855-1942 (México: Secretaría de Relaciones Exteriores, Acervo Histórico Diplomático, 2019), 276 pp.
derecho humano a la vivienda en la jurisprudencia de la Suprema Corte
Authors: Trejo González Luis Carlos
Published: June 2024

Este trabajo tiene por objeto analizar la sentencia del amparo directo en revisión 3516/2013, que contiene la interpretación que la Suprema Corte de Justicia de la Nación sobre el contenido y alcances del derecho a la vivienda a la luz del artículo 4o. de la Constitución Política de los Estados Unidos Mexicanos y los tratados internacionales, con el objeto de analizar la congruencia tanto con los tratados como con la Constitución.