bluuebunny/crossref_metadata_2025 huggingface dataset:
Nanoparticle modification of microfluidic cell separation for cancer cell detection and isolation
Authors: Zhou Yun , Dong Ziye , Andarge Hermella , Li Wei , Pappas Dimitri
Published: October 2019

We present a nanoparticle surface modification approach to improve the microfluidic performance in detecting cancer cells. Multiple cancer cell lines were included in this work, and the capture ability of the chip with surface modification reached a significant increase.
A new approach in voltammetric profiling of wines and whiskies based on a useful faradaic signal component
Authors: Wójcik Szymon , Kopeć Justyna , Baś Bogusław , Jakubowska Małgorzata
Published: October 2019

In this work, we have demonstrated that voltammetric signals obtained using metallic electrodes in a simple supporting electrolyte constitute an adequate tool for distinguishing wine and whisky samples of various characteristics.
A mitochondria–nucleolus migration fluorescent probe for monitoring of mitochondrial membrane potential and identification of cell apoptosis
Authors: Li Meng-Yang , Liu Yan-Hong , Li Kun , Zhang Hong , Shi Lei , Liu Xin-Yao , Yu Kang-Kang , Yu Xiao-Qi
Published: October 2019

A fluorescent probe with large Stokes shifts and excellent photostability was reported for monitoring mitochondria–nucleolus migration.
Comparison of hydrophilic and hydrophobic deep eutectic solvents for pretreatment determination of sulfonamides from aqueous environments
Authors: Ma Yuxin , Wang Qi , Zhu Tao
Published: October 2019

Two types of deep eutectic solvents were synthesized for an aqueous two-phase system to determine the sulfonamides from environmental water samples. The ChCl-Ph based ATPS showed good extraction efficiency. The method avoids use of a large number of extraction solvents.
Micromachined multigroove silicon ATR FT-IR internal reflection elements for chemical imaging of microfluidic devices
Authors: Morhart Tyler A. , Read Stuart T. , Wells Garth , Jacobs Michael , Rosendahl Scott M. , Achenbach Sven , Burgess Ian J.
Published: October 2019

The performance of low-cost, microgroove silicon (Si)-based internal reflection elements (μ-groove IREs) for infrared chemical imaging of microfluidic devices is described.
A cyanine-derivative photosensitizer with enhanced photostability for mitochondria-targeted photodynamic therapy
Authors: Zhao Xuan , Yang Yanjun , Yu Yan , Guo Siming , Wang Wenxing , Zhu Sumin
Published: October 2019

A cyanine-derivative photosensitizer was synthesized with excellent photostability for photodynamic therapy via targeting the cancer cell mitochondria.
Synthesis of structured polysiloxazanes via a Piers–Rubinsztajn reaction
Authors: Ai Liqing , Chen Yi , He Lijuan , Luo Yongming , Li Shuhong , Xu Caihong
Published: October 2019

The first example of the Piers–Rubinsztajn reaction in the synthesis of molecules containing Si–O–Si–N bonds.
A new phosphotungstate-supported rhenium carbonyl derivative: synthesis, characterization and catalytic selective oxidation of thiophenes
Authors: Lu Jingkun , Feng Junwei , Ma Xinyi , Wang Ping , Xu Baijie , He Peipei , Jia Jiage , Ma Pengtao , Niu Jingyang , Wang Jingping
Published: October 2019

We synthesized a new phosphotungstate-supported rhenium carbonyl derivative, [N(CH3)4]6H4[P2W17O62{Re(CO)3}2]·25H2O, existing the first {Re2} fragment. Moreover, it also exhibits high efficiency for the selective oxidation of thiophenes.
Charge-transfer surface-enhanced resonance Raman spectra of benzene-like derivative compounds under the effect of an external electric field
Authors: Ashtari-Jafari Sahar , Khodabandeh Mohammad Hassan , Jamshidi Zahra
Published: October 2019

The singular charge-transfer SERS spectra of symmetric and non-symmetric benzene-like compounds and their selective enhancement under electric field are investigated.
Humic acid regulation of the environmental behavior and phytotoxicity of silver nanoparticles to Lemna minor
Authors: Ding Yuanyuan , Bai Xue , Ye Zhengfang , Gong Dongqing , Cao Jiajing , Hua Zulin
Published: October 2019

Results suggest that molecular interaction occurs between AgNPs and HA functional groups and HA can reduce the toxicity of AgNPs to Lemna minor.
Contaminant removal by efficient separation of in situ formed layered double hydroxide compounds from mine wastewaters
Authors: Somosi Zoltán , Muráth Szabolcs , Nagy Péter , Sebők Dániel , Szilagyi Istvan , Douglas Grant
Published: October 2019

The efficient removal of a range of anionic and cationic contaminants from acid mine waters to facilitate water reuse or for safe discharge constitutes a major environmental challenge.
High compression strength single network hydrogels with pillar[5]arene junction points
Authors: Xu Xiaowen , Jerca Florica Adriana , Van Hecke Kristof , Jerca Valentin Victor , Hoogenboom Richard
Published: October 2019

This study describes a straightforward and versatile approach for synthesizing poly(2-isopropenyl-2-oxazoline) hydrogels with tunable properties by using a bifunctional macrocyclic pillar[5]arene host having two carboxylic acid groups as crosslinker.
Tuning two-dimensional phase formation through epitaxial strain and growth conditions: silica and silicate on NixPd1−x(111) alloy substrates
Authors: Zhou Chao , Liang Xin , Hutchings Gregory S. , Jhang Jin-Hao , Fishman Zachary S. , Wu Rongting , Gozar Adrian , Schwarz Udo D. , Ismail-Beigi Sohrab , Altman Eric I.
Published: October 2019

The combined experimental and theoretical results demonstrate the manipulation of 2D VDW silica and 2D Ni silicate through growth conditions, and the determination of the maximum epitaxial strain imparted to the 2D system through alloy substrate.
Exciton–phonon interaction in quasi-two dimensional layered (PEA)2(CsPbBr3)n−1PbBr4 perovskite
Authors: Long Hao , Peng Xiang , Lu Jianxun , Lin Kebin , Xie Liqiang , Zhang Baoping , Ying Leiying , Wei Zhanhua
Published: October 2019

Exciton–phonon interaction in quasi-2D material was investigated. It was shown that longitudinal optical phonon, rather than acoustic phonon-exciton coupling dominated the enhancement of exciton–phonon coupling strength.
Evolution of local strain in Ag-deposited monolayer MoS2 modulated by interface interactions
Authors: Sun Yinghui , Moe Yan Aung , Xu Yingying , Sun Yufei , Wang Xuewen , Li Fangtao , Liu Kai , Wang Rongming
Published: October 2019

Local strain is best preserved on Al2O3 but relaxed most easily on mica because of the interface interaction from substrates.
Comprehensive control over molecular weight distributions through automated polymerizations
Authors: Rubens Maarten , Junkers Tanja
Published: October 2019

Automated synthesis by mixing of individual polymer distributions to tune the shape and properties of artificial molecular weight distributions.
CO2-Triggered and temperature-switchable crystallization-driven self-assembly of a semicrystalline block copolymer in aqueous medium
Authors: Zhu Rui , Luo Xinjie , Feng Yujun , Billon Laurent
Published: October 2019

The synthesis of a semicrystalline block copolymer comprising a hydrophilic poly(acrylic acid) pure block and an amphiphilic poly(acrylic acid)-r-poly(octadecyl acrylate) random block by nitroxide-mediated polymerization is reported.
In situ transformation of a tridentate to a tetradentate unsymmetric Schiff base ligand via deaminative coupling in Ni(ii) complexes: crystal structures, magnetic properties and catecholase activity study
Authors: Mondal Monotosh , Ghosh Soumavo , Maity Souvik , Giri Sanjib , Ghosh Ashutosh
Published: October 2019

An N2O donor reduced Schiff base in presence of Ni(ClO4)2·6H2O and SCN− transforms into N2O2 donor ligand via deaminative coupling. Metal complexes 1 and 3 exhibit catecholase like activity and antiferromagnetic coupling between the Ni(ii) ions.
Solid-state-stabilization of molecular vanadium oxides for reversible electrochemical charge storage
Authors: Greiner Simon , Anjass Montaha H. , Fichtner Maximilian , Streb Carsten
Published: October 2019

The solid-state stabilization of a molecular vanadium oxide cluster using molecular crystal engineering is reported together with its performance in electrochemical energy storage.
Kinetic modeling and mechanistic investigations of transesterification of propylene carbonate with methanol over an Fe–Mn double metal cyanide catalyst
Authors: Song Ziwei , Subramaniam Bala , Chaudhari Raghunath V.
Published: October 2019

A kinetic model involving the activation sequence of reactants PC, methanol and an intermediate provides the best description of the experimental data with respect to reaction parameters over a wide range of conditions.
Introducing an identical benzodithiophene donor unit for polymer donors and small-molecule acceptors to unveil the relationship between the molecular structure and photovoltaic performance of non-fullerene organic solar cells
Authors: Zhang Youdi , Shi Laitao , Yang Tao , Liu Tao , Xiao Yiqun , Lu Xinhui , Yan He , Yuan Zhongyi , Chen Yiwang , Li Yongfang
Published: October 2019

We designed an acceptor ITIC-SF by fluorinating the thiophene ring in the benzodithiophene segment of ITIC-S and investigated its effect on the morphology and performance.
Comparison of AC breakdown characteristics on insulation paper (pressboard) immersed by three‐element mixed insulation oil and mineral oil
Authors: Feng Dawei , Hao Jian , Yang Lijun , Liao Ruijin , Chen Xin , Li Jian
Published: October 2019

Insulation oil is an important dielectric in power devices, and many studies on mixed insulation oil have been conducted in recent years to improve the performance of insulation oils. To replace mineral oil directly, the authors previously developed a novel three‐element mixed insulation oil successfully; the main parameters of which satisfy the IEC 60296‐2012 standard for mineral oil. In the present study, the AC breakdown properties of insulation paper (pressboard) immersed by the new mixed oil and naphthenic mineral oil were compared. For both insulation oils, the increase in temperature cannot significantly reduce the breakdown strength of oil‐immersed insulation paper (pressboard) at a low moisture content, and the increment of moisture content cannot reduce the breakdown voltage at a low temperature (25°C). The breakdown voltage decreases only when the two factors increase simultaneously. For the mixed and mineral oils, the AC breakdown voltage of oil‐immersed paper (pressboard) with different thicknesses has significant difference. The mineral oil has a high breakdown voltage for the thin insulation paper, whereas the mixed oil has a high breakdown voltage when the thickness of the insulation paper (pressboard) exceeds 0.2 mm. This phenomenon is mainly caused by the breakdown field strength that varies with the increase of dielectric thickness and the different change trends of paper (pressboard) immersed with the mixed and the mineral oils. Moreover, the stack of thin multilayer insulation paper enables the mixed oil‐immersed paper to have a higher breakdown strength than the mineral oil‐immersed paper. For the AC breakdown voltage of oil‐immersed pressboard with an oil‐gap structure, the mixed oil is comprehensively superior to the mineral oil due to its larger relative permittivity.
Ensemble of fine‐tuned convolutional neural networks for urine sediment microscopic image classification
Authors: Liu Wenqian , Li Weihong , Gong Weiguo
Published: October 2019

In this study, an ensemble of fine‐tuned convolutional neural networks (CNNs) is proposed. As CNN training requires large annotated data, which are lacking in the field of urine sediment microscopic image processing, the authors first pre‐trained the CNNs, including ResNet50 and GoogLeNet, and developed AlexNet on an ImageNet dataset. Thereafter, some of the weights of the pre‐trained CNNs were transferred to the urine sediment microscopic image dataset. To guide fine‐tuning of the learning rate and cascading features, the hierarchical nature of features in different convolutional layers was investigated by visualising the CNN. Then, they combined three CNNs as an ensemble of CNNs to decrease the differences and impurity interference among features of urine sediment microscopic image. These fusion features were employed to train the fully connected neural network for classification. In this study, they improved the accuracy of each CNN by an average of 2.2% through fine‐tuning of the learning rate and cascading features. Moreover, the better experimental results were achieved compared with other state‐of‐the‐art methods and indicated that a 97% classification accuracy can be attained.
Method for four‐channel monopulse radar to resist dual‐source angle deception jamming
Authors: Jianlu Wang , Xiong Xu , Huanyao Dai , Danhui Sun , Huidong Qiao
Published: October 2019

Towed decoy can simulate the time domain and frequency domain characteristics of target in radar beam and form effective angle deception. In order to improve the radar ability to countermeasure towed decoy, this study extracts and uses the radar diagonal difference channel in the conventional monopulse radar. The characteristic of diagonal difference channel is analysed. Then, the equations of sum channel, azimuth difference channel, elevation difference channel, and diagonal difference channel are established. By solving the equations, the angles and amplitude of decoy and target are obtained. Decoy recognition method is proposed. The new method can obtain the angles of decoy and target using only one pulse, and recognise decoy steadily using several pulses. The simulation results confirm the effectiveness of the new method.
Cognitive target detection based on Bayesian approach in radar
Authors: Ma Ning , Wang Li , Tang Jun , Liao Qingmin , Zhang Yunlei
Published: October 2019

Cognitive radar (CR), which uses a closed‐loop feedback perception‐action cycle system, aims to develop a higher level of intelligence. In this study, the authors develop an efficient Bayesian approach to target detection in CR. The approach, which uses the Neyman‐Pearson criterion with priori probability, can improve the target detection effectively. The recursive form of computing priori probability is also discussed. Numerical simulations illustrate that the proposed target detector can improve the performance of detection with the usage of priori probability, which can be computed recursively using the previous measurements.
Autofocusing method for through‐the‐wall bioradar imagery of human vital signs
Authors: Liang Fulai , Li Haonan , Liu Miao , Wang Pengfei , Wang Jianqi
Published: October 2019

In through‐the‐wall human imaging, ambiguities in wall parameters will cause image blurred and deteriorate signal‐to‐clutter ratio of vital signs. Autofocusing method is a kind of method to get focusing image without any information of wall. This method is based on the idea that the focusing performance improves when estimated wall parameters are close to the true parameters. In traditional autofocusing methods, the interesting targets such as the point‐like targets are selected as the reference targets to assess the focusing performance of image. However, in some cases, especially in through‐the‐wall imaging of human vital signs, the existence of human cannot be assured before detection and discrimination. Nevertheless, high‐performance detection of human is the aim of imaging. The wall always exists in the imaging area, and reflections of wall edges are stronger than the interested vital signs. Thus, in this study the authors select the edges of wall as the prominent targets. The linearity degree of wall edges is adopted as the assessment item of focusing performance since the images of wall edges after compensating the wall parameters are lines approximately. Simulation results show that the proposed autofocusing method can effectively improve the focusing performance of human vital signs.
Full‐polarimetric scattering characteristics prediction from single/dual‐polarimetric SAR data using convolutional neural networks
Authors: Zhang Juan , Qiu Xiaolan , Wang Xiangfeng , Jin Yan
Published: October 2019

Scattering entropy (H), scattering angle (α) and anti‐entropy (A) are useful parameters in synthetic aperture radar (SAR) image classification. Usually, full‐polarimetric SAR data are needed to extract these parameters. In this study, the authors firstly try to predict these parameters from single/dual‐polarimetric SAR data using convolutional neural network. Experiments are done on GF‐3 polarised SAR database, and promising results are obtained, where the parameters H and α, the average relative error reached is <10%, the parameter A, the average relative error reached is around 25%, and the classification performance based on predictive parameters is around 80%. Furthermore, the predicting performance using different single‐ and dual‐polarisation is compared. The results and conclusions provide a new clue for the applications of single/dual‐polarimetric SAR.
Classifying aircraft based on sparse recovery and deep‐learning
Authors: Wenying Wang , Yao Wei , Xuanxuan Zhen , Hui Yu , Ruqi Wang
Published: October 2019

A hybrid CS‐DL method for aircraft classification in complex electromagnetic environment is introduced. To classify aircraft from interfered radar echoes, the authors propose a novel classification method based on compressed sensing (CS) and deep‐learning (DL). After recovering the spectrum polluted by jamming signals by using CS, they exploit sparse auto‐encoder (SAE) to extract modulation features and then classify aircraft. The method is tested by 536 flights of three types of airplanes, and the results show that the correct classification rate reaches 75% even when 41% of the pulses are interfered.
Influence of kernel clustering on an RBFN
Authors: Zhu Changming , Miao Duoqian
Published: October 2019

Classical radial basis function network (RBFN) is widely used to process the non‐linear separable data sets with the introduction of activation functions. However, the setting of parameters for activation functions is random and the distribution of patterns is not taken into account. To process this issue, some scholars introduce the kernel clustering into the RBFN so that the clustering results are related to the parameters about activation functions. On the base of the original kernel clustering, this study further discusses the influence of kernel clustering on an RBFN when the setting of kernel clustering is changing. The changing involves different kernel‐clustering ways [bubble sort (BS) and escape nearest outlier (ENO)], multiple kernel‐clustering criteria (static and dynamic) etc. Experimental results validate that with the consideration of distribution of patterns and the changes of setting of kernel clustering, the performance of an RBFN is improved and is more feasible for corresponding data sets. Moreover, though BS always costs more time than ENO, it still brings more feasible clustering results. Furthermore, dynamic criterion always cost much more time than static one, but kernel number derived from dynamic criterion is fewer than the one from static.
Effect of mechanical activation on the structure of pulverized coal and iron ore powder
Authors: Wei Rufei , Xiang Dongwen , Long Hongming , Li Jiaxin , Meng Qingmin
Published: October 2019

Morphologies and structures of pulverized coal and iron ore powder after mechanical activation were studied by SEM, XRD, FTIR and laser particle sizer. The microcrystalline structure of coal was found to be destroyed by mechanical activation via reducing the pile height and number of layers, and the organic structure of coal was altered through the destruction of the ether bond. Mechanical activation led to distortions and dislocations of the crystal lattice of iron ore, decreasing crystallite size, increasing the grain boundary area, and producing an amorphous phase. These increased the Gibbs free energies of dislocations and grain boundaries as well as the surface Gibbs free energy and the amorphization Gibbs free energy, which would eventually increase the energy stored in iron ore called mechanical storage energy. The longer the mechanical activation process, the higher mechanical storage energy for the iron ore will be saved. The amorphization Gibbs free energy is the biggest among the four kinds of Gibbs free energy, accounting for 94.8% ∼ 87.1% of the total storage energy in the mechanical activated iron ore.
Diagnostic Performance and Reliability of Non-Enhanced Imaging Characterization Quotients for the Differentiation of Infectious and Malignant Pulmonary Nodules in Hematological Patients Using 3T MRI
Authors: Nagel Sebastian Niko , Kim Damon , Wylutzki Tatjana , Steffen Ingo G. , Schwartz Stefan , Penzkofer Tobias , Hamm Bernd , Elgeti Thomas
Published: October 2019

Purpose To evaluate the diagnostic performance and reliability of non-enhanced imaging characterization quotients (NICQs) derived from magnetic resonance imaging (MRI) in the differential diagnosis of pulmonary nodules in hematological patients.

Materials and Methods A total of 83 lesions in 45 consecutive hematological patients were analyzed (10 bacterial pneumonias, 16 fungal pneumonias, 19 pulmonary lymphoma manifestations). The MRI protocol included T2-weighted single-shot fast spin echo (FSE) and T1-weighted gradient echo (GRE) sequences. T2-based T2-NICQmean and T2-NICQ90th were calculated from signal intensities measured in the lesion, muscle, and fat ((SILesion – SIMuscle)/(SIFat – SIMuscle) * 100), and simple T1-based T1-Qmean from signal intensities of the lesion and muscle (SILesion/SIMuscle). Images were read by one radiologist with > 7 years and one with 1 year of experience. For statistical evaluation the Kruskal-Wallis or Mann-Whitney U-test, receiver operating characteristic (ROC) analysis with calculation of areas under the curve (AUC), and intraclass correlation coefficients (ICCs) were used.

Results Medians of T2-NICQs differed significantly when comparing infectious lesions and lymphoma manifestations in general (T2-NICQmean 20.33 vs. 10.14; T2-NICQ90th 34.96 vs. 25.52) or fungal lesions and lymphoma manifestations in particular (T2-NICQmean 19.00 vs. 10.14; T2-NICQ90th 34.49 vs. 25.25). The AUCs for T2-NICQs on the per-patient level ranged from 0.73 to 0.79. ICCs were at least > 0.85, except for intrarater testing of T2-NICQ90th (0.79).

Conclusion The overall diagnostic performance of T2-NICQs is adequate for differentiating infectious and fungal lesions from lymphoma manifestations. The results show good to excellent intra- and interrater agreement. We therefore consider NICQs helpful in the diagnostic workup of pulmonary nodules in hematological patients.

Key points: 

Citation Format
Cardiac Autonomic and Physiological Responses to Moderate- intensity Exercise in Hypoxia
Authors: Fornasiero Alessandro , Skafidas Spyros , Stella Federico , Zignoli Andrea , Savoldelli Aldo , Rakobowchuk Mark , Pellegrini Barbara , Schena Federico , Mourot Laurent
Published: October 2019

Exercise physiological responses can be markedly affected by acute hypoxia. We investigated cardiac autonomic and physiological responses to different hypoxic training protocols. Thirteen men performed three exercise sessions (5×5-min; 1-min passive recovery): normoxic exercise at 80% of the power output (PO) at the first ventilatory threshold (N), hypoxic exercise (FiO2=14.2%) with the same PO as N (HPO) and hypoxic exercise at the same heart rate (HR) as N (HHR). PO was lower in HHR (21.1±9.3%) compared to N and HPO. Mean HR was higher in HPO (154±11 bpm, p<0.01) than N and HHR (139±10 vs. 138±9 bpm; p=0.80). SpO2 was reduced (p<0.01) to a similar extent (p>0.05) in HPO and HHR compared to N. HR recovery (HRR) and HR variability indices were similar in N and HHR (p>0.05) but reduced in HPO (p<0.05), mirroring a delayed parasympathetic reactivation. Blood lactate and ventilation were similar in N and HHR (p>0.05) and increased in HPO (p<0.001). During recovery oxygen consumption and ventilation were similar in N and HHR (p>0.05) and increased in HPO (p<0.01). Moderate HR-matched hypoxic exercise triggers similar cardiac autonomic and physiological responses to normoxic exercise with a reduced mechanical load. On the contrary, the same absolute intensity exercise in hypoxia is associated with increased exercise-induced metabolic stress and delayed cardiac autonomic recovery.
Warum und wie fördern Menschen Medizin? Spenderverhalten an Universitätskliniken in Deutschland
Authors: Ness Jorit , Heyder Ralf , Hassel Thomas , Helfers Carina , Horst Pit , Kreßirer Philipp , Lutz Roger , Metzger Sabine , Morchner Annika , Raubinger Anja , Schenke Eckhard , Stumpf Birgit , Pieper Claudia , Jöckel Karl-Heinz
Published: October 2019

Zielsetzung Viele Einrichtungen im Gesundheitswesen erzielen hierzulande Spenden in beträchtlichem Umfang, die Projekte über den medizinischen Versorgungsbedarf finanzieren. Die vorliegende Studie untersucht Motive, Einflussfaktoren und soziodemografische Merkmale von Spendern, die auf dem Gebiet der Universitätsmedizin Projekte in Krankenversorgung, Forschung und Lehre unterstützen.

Methodik Die acht teilnehmenden Universitätskliniken versandten an 7205 ihrer Spenderinnen und Spender einen vierseitigen Fragebogen. Es wurden soziodemografische Daten ausgewertet und persönliche Interessen und Motive im Zusammenhang mit getätigten Spenden erfragt.

Ergebnisse 60 % der 1317 Responder sind ehemalige Patienten der Einrichtung, zu deren Gunsten sie spenden. Zwei Drittel der Responder sind verheiratet, im Ruhestand und verfügen zumeist über ein monatliches Haushaltsnettoeinkommen zwischen 1500 und 2500 EUR. Die älteren Teilnehmer spenden häufiger aus Dankbarkeit für die erhaltene medizinische Versorgung, die Jüngeren aus altruistischer Motivation heraus. Es existiert ein signifikanter Zusammenhang zwischen dem Einkommen und der Bereitschaft, eine Testamentsspende vorzunehmen.

Schlussfolgerung Spender an Einrichtungen des Gesundheitswesens in Deutschland weisen heterogene Motivationslagen auf. Die Spendenmotivation ist abhängig von soziodemografischen Einflussfaktoren. Die Studie vermittelt Einblicke, wie sich Einrichtungen im Gesundheitswesen positionieren können, um Spenden für ihre zusätzlichen Bedarfe zu erhalten.
Reflektorische Atemtherapie bei Patienten mit idiopathischem Parkinson-Syndrom – Einarmige Pilotstudie
Authors: Neumann Nadine , Kiselev Jörn , Pinter Michaela M. , Mohokum Melvin
Published: October 2019

Hintergrund Beim idiopathischen Parkinson Syndrom (IPS) handelt es sich um die häufigste neurologische Erkrankung in Deutschland. Die Patienten haben ein erhöhtes Risiko, sekundär eine Störung der Lungenfunktion zu entwickeln. Die reflektorische Atemtherapie ist eine spezielle Form der Atemtherapie zur Behandlung von Lungenfunktionsstörungen.

Ziel Das Ziel dieser Pilotstudie war, die Anwendbarkeit der reflektorischen Atemtherapie bei Patienten mit IPS zu untersuchen.

Methode In der einarmigen interventionellen Pilotstudie erhielten die Probanden in der 3-wöchigen Interventionsphase 2 Behandlungen reflektorische Atemtherapie pro Woche. Die Verlaufsdokumentation erfolgte anhand des Parkinson’s Disease Questionnaire (PDQ) 39, der Spirometrie und des 6-Minuten-Gehtests. Zudem wurden die Zufriedenheit und der Studienabbruch der Studienteilnehmer erfasst und die Daten deskriptiv ausgewertet.

Ergebnisse Insgesamt wurden 10 Probanden eingeschlossen. Bei 9 Teilnehmern konnte die Therapie durchgeführt werden. Bei der Verlaufsdokumentation zeigten sich für eine Mehrheit der Patienten gleichbleibende bis positive Entwicklungen der krankheitsbezogenen Lebensqualität und der Gehstrecke. Die Zufriedenheit lag bei 9,44 (± 0,69) von 10 Punkten. Sowohl Drop-outs als auch Lost-to-Follow-up wurden erfasst.

Schlussfolgerung Bei Patienten mit IPS ist die reflektorische Atemtherapie eine ergänzende Behandlungsmethode. Die erfassten klinischen Daten können als Anhaltspunkte für nachfolgende wissenschaftliche Studien dienen.
Term Neonate Presenting with the Combined Occurrence of Mucolipidosis Type II and Leigh Syndrome
Authors: Speer Rebecca R. , Ezeanya Uzoamaka C. , Beaudoin Sarah J. , Glass Kristen M. , Oji-Mmuo Christiana N.
Published: October 2019

Mucolipidosis II α/beta (MLII) is an autosomal recessive disease in which a gene mutation leads to improper targeting of lysosomal enzymes with an end result of accumulation of lysosomes in the mitochondria resulting in a dysfunctional mitochondria.1 Leigh syndrome (LS) is a rare progressive neurodegenerative disorder associated with dysfunctional mitochondria and oxidative phosphorylation.4 Both disease processes typically present in infancy.3
7 Herein, we present a case of an infant diagnosed with both mucolipidosis II and Leigh syndrome. Genetic analysis in this case revealed two mutations (NDUFA12 c.178C > T p.Arg60* and GNPTAB c.732_733delAA) on the long arm of chromosome 12 as the etiology of MLII and LS in this neonate, respectively. We are unaware of any previously published cases of the presence of these two diseases occurring in the same patient. The complex clinical presentation of this case led to a delay in the diagnosis, and we believe that the clinical phenotypes of these two conditions were likely worsened. The genetic alterations presented in this case occurred as a result of mutations on chromosome 12. We suggest further investigation into the potential overlap in the pathophysiology, specifically the inheritance pattern, linkage disequilibrium, mitochondrial–lysosomal interaction, or crosstalk contributing to both diseases.
Electrochemical memristive devices based on submonolayer metal deposition
Authors: Pragnya Prachi , Pinkowitz Ainsley , Hull Robert , Gall Daniel
Published: October 2019

This paper explores the concept of an analog memristive device based on reversible electrochemical deposition and deplating of a submonolayer metal layer on a 108 Ω resistive bar. Initial feasibility experiments demonstrate a continuous resistance change by seven orders of magnitude during physical vapor deposition of Cu on TaNx/SOI, with the most promising range from 5.6 × 107 to 1.1 × 107 Ω/□ during a 0.64 monolayer Cu deposition. Cyclic electrochemical deposition and deplating of Cu on a metal seed on SiO2 in a 0.01M CuSO4/H2SO4 pH 1.4 solution demonstrates a reversible resistance variation with a minimum of 10 ± 1 discrete resistance states. These initial results are promising but also reveal a key materials challenge: the need for controlled and reversible electrochemical deposition/deplating of a submonolayer metal on the surface of a relatively high resistivity (≥10−2 Ω m) material.
Role of the electron-phonon coupling on the thermal boundary conductance of metal/diamond interfaces with nanometric interlayers
Authors: Blank Maïté , Schneider Gionata , Ordonez-Miranda Jose , Weber Ludger
Published: October 2019

Thermal boundary conductance (TBC) of the Ag/diamond and Au/diamond interfaces with a nanometer-thick interface layer of either nickel or molybdenum is measured by time domain thermoreflectance and modeled based on a 3-layer two-temperature model (3l-TTM). The rationale for this study is to critically assess the role of the electron-phonon coupling factor of the interlayer along with its thickness on the TBC. It is shown that the TBC of both systems rapidly increases with the interlayer thickness until reaching a stable plateau for thicknesses greater than 1.5 nm. The plateau average value is 15%–25% lower than the intrinsic TBC between the interlayer material and the diamond substrate. This behavior and values of the TBC of both systems are in good agreement with the predictions of the 3l-TTM. The predictability of this model is also analyzed for a Cu interlayer inserted at Au/silicon interfaces with thicknesses ranging from 1.5 to 20 nm. While the room temperature TBC of this system is well described by the 3l-TTM, the values measured at 80 K can only be predicted by the 3l-TTM, provided that the interlayer electron-phonon coupling factor is reduced by a factor of 2, as was experimentally observed for Ag and Au. The obtained experimental results along with the proposed model can thus be useful for tailoring the TBC of metallic interfaces in a wide range of temperatures.
Terahertz emission from a weakly-coupled GaAs/AlGaAs superlattice biased into three different modes of current self-oscillations
Authors: Rasulova G. K. , Pentin I. V. , Goltsman G. N.
Published: October 2019

Radio-frequency modulated terahertz (THz) emission power from weakly-coupled GaAs/AlGaAs superlattice (SL) has been increased by parallel connection of several SL mesas. Each SL mesa is a self-oscillator with its own oscillation frequency and mode. In coupled non-identical SL mesas biased at different voltages within the hysteresis loop the chaotic, quasiperiodic and frequency-locked modes of self-oscillations of current arise. THz emission was detected when three connected in parallel SL mesas were biased into the frequency-locked and quasiperiodic modes of self-oscillations of current, while in the chaotic mode of those it falls to the noise level.
A substantial increase of Curie temperature in a new type of diluted magnetic semiconductors via effects of chemical pressure
Authors: Yu Shuang , Zhao Guoqiang , Peng Yi , Zhu Xiaohong , Wang Xiancheng , Zhao Jianfa , Cao Lipeng , Li Wenmin , Li Zhi , Deng Zheng , Jin Changqing
Published: October 2019

Chemical pressure is an effective method to tune physical properties, particularly for diluted magnetic semiconductors (DMSs) of which ferromagnetic ordering is mediated by charge carriers. Via substitution of smaller Ca for larger Sr, we introduce chemical pressure on (Sr,Na)(Cd,Mn)2As2 to fabricate a new DMS material (Ca,Na)(Cd,Mn)2As2. Carriers and spins are introduced by substitutions of (Ca,Na) and (Cd,Mn), respectively. The unit cell volume reduces by 6.2% after complete substitution of Ca for Sr, suggesting a subsistent chemical pressure. Importantly, the local geometry of the [Cd/MnAs4] tetrahedron is optimized via chemical compression that increases the Mn–As hybridization leading to enhanced ferromagnetic interactions. As a result, the maximum Curie temperature (TC) is increased by about 50% while the maximum saturation moment increases by over 100% from (Sr,Na)(Cd,Mn)2As2 to (Ca,Na)(Cd,Mn)2As2. The chemical pressure estimated from the equation of state is equal to an external physical pressure of 3.6 GPa.
Extreme low-frequency ultrathin acoustic absorbing metasurface
Authors: Donda Krupali , Zhu Yifan , Fan Shi-Wang , Cao Liyun , Li Yong , Assouar Badreddine
Published: October 2019

We introduce a multicoiled acoustic metasurface providing quasiperfect absorption (reaching 99.99% in experiments) at an extremely low-frequency of 50 Hz, simultaneously featuring an ultrathin thickness down to λ/527 (1.3 cm). In contrast to the state of the art, this original conceived multicoiled metasurface offers additional degrees of freedom capable of tuning the acoustic impedance effectively without increasing the total thickness. We provide analytical derivation, numerical simulation, and experimental demonstrations for this unique absorber concept, and discuss its particular physical mechanism. Furthermore, based on the same conceptual approach, we propose a broadband low-frequency metasurface absorber by coupling unit cells exhibiting different properties.
Large surface conductance and superconductivity in topological insulator microstructures
Authors: Li Yangmu , Wu Jie , Camino Fernando , Gu G. D. , Božović Ivan , Tranquada John M.
Published: October 2019

Controllable geometric manipulation via micromachining techniques provides a promising tool for enhancing useful topological electrical responses relevant to future applications such as quantum information science [P. J. W. Moll, “Focused ion beam microstructuring of quantum matter,” Annu. Rev. Condens. Matter Phys. 9, 147 (2018); Jang et al., “Observation of half-height magnetization steps in Sr2RuO4,” Science 331, 186 (2011); Moll et al., “Transport evidence for Fermi-arc-mediated chirality transfer in the Dirac semimetal Cd3As2,” Nature 535, 266 (2016); Moll et al., “Evidence for hydrodynamic electron flow in PdCoO2,” Science 351, 1061 (2016)]. Here, we present microdevices fabricated with a focused ion beam from an indium-doped topological insulator Pb1−xSnxTe. With the device thickness on the order of 1 μm and an extremely large bulk resistivity, we achieve an unprecedented enhancement of the surface contribution to about 30% of the total conductance near room temperature. The surface contribution increases as the temperature is reduced, becoming dominant below approximately 180 K, compared to 30 K in millimeter-thickness crystals. In addition to the enhanced surface contribution to normal-state transport, we observe the emergence of surface superconductivity below 6 K. Measurements of magnetoresistivity at high magnetic fields reveal a weak antilocalization behavior in the normal-state magnetoconductance at low temperatures and a variation in the power-law dependence of resistivity on temperature with the field. These results demonstrate that interesting electronic responses relevant to practical applications can be achieved by suitable engineering of single crystals.
The type specimen of Murexia longicaudata (Dasyuromorphia : Dasyuridae): an enigma
Authors: Woolley P. A.
Published: October 2019

Examination of the skull and dentaries of the type specimen of Murexia longicaudata has led to the conclusion that the holotype is either a highly abnormal individual or that the skull and dentaries are mismatched. The dentaries may be those of a smaller individual. The matter might be resolved if genetic studies were to be carried out on both.
Identificeerbaarheid van kinderen met een gehoorbeperking
Authors: Boonen Nathalie , Kloots Hanne , Gillis Steven
Published: October 2019

Studies on the speech and language development of hearing-impaired children often focus on (deviations in) the
children’s speech production. However, it is unclear if listeners also perceive differences
between the speech of normally hearing and hearing-impaired children. This contribution wants to fill this void by investigating
the overall perceived speech quality of both groups. Three groups of listeners (speech and language pathologists, primary school
teachers and inexperienced listeners) judged 126 utterances of seven normally hearing children, seven children with an acoustic
hearing aid and seven children with a cochlear implant, in a comparative judgment task. All children were approximately seven
years old and received, in the case of the hearing-impaired children, their assistive hearing device before the age of two.

The online tool D-PAC was used to administer the comparative judgement task. The listeners compared stimuli in
pairs and decided which stimulus sounded best. This method ultimately leads to a ranking in which all stimuli are represented
according to their overall perceived speech quality.

The main result is that the speech of normally hearing children was preferred by the listeners. This indicates
that, even after several years of device use, the speech quality of hearing-impaired children is perceived as different from that
of normally hearing children. Within the group of hearing-impaired children, cochlear implanted children were judged to exhibit
higher speech quality than acoustically hearing aided children, especially after a longer device use. The speech quality of the
latter group, on the other hand, remained practically stable. Listeners, irrespectively of their degree of experience with
(hearing-impaired) children’s speech, completed the task similarly. In other words: the difference between the overall perceived
speech quality of normally hearing and hearing-impaired children is salient for all listener groups and they all slightly
preferred children with a cochlear implant over children with an acoustic hearing aid.
A study on the comprehension of graphic representations of architectural project designs by elderly users
Authors: Oliveira Aquino Ivana Figueiredo de
Published: October 2019

The elderly population is increasing worldwide, leading to a growing concern about the quality of life of this segment of the population, including housing issues. Aging brings several perceptual, cognitive and motor limitations that make it difficult to understand spatial information. These limitations have an impact on the elderly’s understanding of graphic representations of dwelling projects, as effectiveness in the communication between architects and elderly users may be jeopardized. With this in mind, a study on elderly users’ understanding of project representations was conducted in Brazil. The study investigated the understanding of three project representations: 2D technical drawings; electronic model with 3D static perspectives of the space; and digital simulation of virtual tour through a house project. 15 people took part in the study. In general, the results showed poor comprehension of all representations, the virtual tour representation yielding the most positive outcomes. The possible influence of age and gender on the performance of the participants is discussed. It is concluded that ageing and realism in depiction affect elderly users’ assimilation of information presented in architectural projects, corroborating the literature.
Verb learning and the acquisition of aspect
Authors: Nishi Yumiko , Shirai Yasuhiro
Published: October 2019

Although SLA research has extensively investigated the role of lexical aspect in L2 acquisition of tense-aspect
marking, the role of L1 is not yet fully understood. This paper investigates the effect of cross-linguistic variation in lexical
aspect and explores how the learning of lexical aspect interacts with the acquisition of aspectual morphology, using oral
picture-description and written judgment tasks. 391 learners of Japanese (L1 English, Chinese, and Korean) participated in the
study. The results show that L2 learners have problems in rejecting incorrect L2 aspectual structures (but not in accepting
correct ones) when such structures involve L1–L2 discrepancy in lexical aspect. The results also confirmed a strong L1 effect at
the level of surface inflected verbal form, showing significantly higher accuracy for items for which direct translation yields
correct meaning than those that do not. It is argued that L1 transfer may be playing an important role in the L2 acquisition of
aspect in that both positive and negative transfer collectively determine the order of acquisition predicted by the Aspect
Hypothesis.
Swamp Land Utilization for Socio-cultural, Economic and Potential Development of Lake OPI Ecotourism in Palembang
Authors: Husin A
Published: October 2019

South Sumatra has a vast swamp area, now along with the development of the population the land needs an increase, so that much swamp land is converted into housing, offices, business centres, and others. One of the housing complexes that used to be a swamp is the OPI housing in Jakabaring. Amid the Jakabaring OPI housing there is a swamp that becomes a lake by the developer. This lake is quite extensive, and interesting because the environment is still beautiful and there is no construction of tall buildings except housing. The lake looks beautiful yet untouched to become an ecotourism area, so the lake has great potential to become a tourist land for the community. This study aims to find out how people utilize this tourism potential from socio-cultural and economic aspects which ultimately leads to the use of being an ecotourism area. Research uses two methods namely quantitative and qualitative descriptive. The research respondents were 40 people from the surrounding community. The research findings obtained that the community exploits the lake’s potential in the aspects of social, economic, and ecotourism. The utilization that is often carried out is on the socio-cultural aspects, in the economic aspect the categories are quite utilizing, on the other hand the utilization of ecotourism aspects is still weak. For this reason, it is recommended that the regional government provide support so that the lake is maximally utilized by the community as an ecotourism area. Which ultimately prosper the community.
Optimizing Building Planning and Design to Control External Energy Loads
Authors: Sandi R Y , Ismail M
Published: October 2019

In Indonesia, the building sector is responsible for 50% of the total energy consumption from all sectors and more than 70% of overall electricity consumption. The highest energy loads of the office sector is around 57% of the building and 50% of the energy loads on the building belongs to the air conditioning. This study attempted to optimize planning and design, especially through controlling the external energy loads (heating) that enter the building envelope (wall and vents). Case study was conducted in Makassar at Residential and Building Development Information Center (PIP2B Building). The method utilized OTTV (Overall Thermal Transfer Value) consisting of planning and building design analysis especially accounting for heat energy entering the building through windows and vents of the building. According to the Ministry Public works regarding OTTV, the standard for building the energy conservation was 45 W/m2 but the standar was increased to 30-35 W/m2. From the results of OTTV calculations, an external energy load entered into the building through the building envelope (walls and windows). The result of OTTV calculation shows that some sides of building have an increased amount of energy that went through the wider windows. Through optimizing and planning the windows area, thedecreasing external energy (heat energy) that entered from the outside is encouraged.
Neighbourhood Relationship among Villages in Gedangan District: Multidimensional Poverty Approach
Authors: Ari I R D , Hariyani S , Waloejo B S
Published: October 2019

Poverty becomes one of the global problems especially in developing country. Poverty is condition when people have difficulty to access basic needs and unable access it. This research takes place at Gedangan District, Malang Regency. This research aims are to: i) measure multidimension poverty index and ii) find out neighbourhood relationship among villages in Gedangan District. There are two research methods which are are used: i) Multidimensional Poverty Index (MPI) – consists of three dimensions (health, education and living standard); and ii) Spatial Data Analysis. MPI value measurement indicates that there are 2 MPI levels: low level (4 villages) and medium level (4 villages). Therefore, based on the MPI measurement, there are 4 villages with medium level of MPI as the priority villages to deal with poverty. The result of LISA map by spatial data analysis indicates that cluster of Low-High is form by Sidodadi village. It means that there are inequality facilities services between low value area and high value area. Sidodadi gets better services than its neighbour because it gets better service from another district, and it is vice versa for the village that have high value but does not get good facility services from Gedangan District.