bluuebunny/crossref_metadata_2025 huggingface dataset:
КОМПЛЕКСНОЕ ИСПОЛЬЗОВАНИЕ НЕКОНДИЦИОННОГО НЕФРИТА
Authors: Худякова Людмила Ивановна , Кислов Евгений Владимирович , Палеев Павел Леонидович , Малышев Алексей Владимирович
Published: August 2020

Актуальность. В последние годы наблюдается повышенный интерес к нефриту. Спрос на него требует разработки новых месторождений. Однако более 70 % добытого нефритсодержащего сырья является некондиционным, невостребованным, оказывающим отрицательное воздействие на разные сферы жизни. Кроме того, происходит расхищение некондиционного нефрита и вовлечение его в незаконный оборот. В связи с чем использование его в производстве различных видов продукции является актуальной задачей не только с экологической, но и с технологической стороны. Цель: установить возможность использования некондиционного нефритсодержащего сырья в производстве строительных материалов. Объекты: нефритсодержащие породы Улан-Ходинского месторождения Восточного Саяна. Методы: химический, гранулометрический, механический методы анализа. Результаты. Дана характеристика Улан-Ходинского месторождения Восточного Саяна. Изучены некондиционные породы, образуемые в результате добычи и выделения ценных фракций из нефритсодержащего сырья. Установлено, что щебень из них имеет высокое качество. Он относится к Первой группе щебня, устойчив против всех видов распадов и стойкий к воздействию окружающей среды. Песок из отсевов дробления некондиционного нефрита является крупным песком с зернами угловатой формы, обеспечивающей качество получаемых материалов. Определен модуль кислотности породы равный 1,59; модуль основности – 0,63; силикатный модуль – 12,66; а коэффициент качества – 0,66. По своим показателям некондиционный нефрит имеет высокое качество и может использоваться в производстве строительных материалов. Однако установлено, что он не обладает возможностью твердеть самостоятельно, но способен выступать в роли гидравлической добавки в составе композиционных материалов. Получены цементные вяжущие композиции с добавкой некондиционного нефритсодержащего сырья, изучены их физико-механические свойства. Установлено, что прочность материалов зависит от количества добавки и времени измельчения сырьевой смеси. Определены технологические параметры получения тяжелых бетонов с использованием нефрита. Выводы. Таким образом, некондиционный нефрит представляет собой перспективный сырьевой материал для получения новых видов строительных материалов. Вовлечение его в производственный оборот позволит извлекать дополнительную прибыль при переработке нефритсодержащего сырья, а также минимизировать негативное воздействие добывающих предприятий на окружающую природную среду. Кроме того, утилизация некондиционного нефрита предотвратит его расхищение и вовлечение в незаконный оборот нефрита.
División natural
Authors: Chávez Chuquimango Maria Angelica
Published: August 2020

EN UN MUNDO URBANIZADO Y EN UNA SOCIEDAD DE CONSUMO RÁPIDO, LA NATURALEZA, MUCHASVECES LEJANA E INALCANZABLE, HA IDO ADQUIRIENDO CATEGORÍA DE SUEÑO, DE RECREACIÓN, DE IMAGENONÍRICA. ÓSCAR MONTOBBIO, ALUMNO DE LA CARRERA DE COMUNICACIÓN Y FOTOGRAFÍA, HA OBSERVADO LOS DIFERENTES ÁNGULOS DE LA INTERVENCIÓN DEL SER HUMANO SOBRE LA NATURALEZA
Análisis de la fotografía periodística como documento histórico para la creación de memoria social en la época del terrorismo en el Perú
Authors: Vallejo Moreno Joaquín Antonio
Published: August 2020

RESUMEN:Es innegable el aporte que ofrece la fotografía periodística en la construcción de memoria social sobre todo si se trata de sociedades donde ocurrieron traumas sociales como lo fue el terrorismo en el Perú entre los años 1980 al 2000.El presente artículo es un complemento de la tesis doctoral que el autor desarrolla sobre el estudio de la fotografía periodística como documento histórico válido, teniendo en cuenta el contexto de la publicación y la línea editorial del medio de comunicación en donde aparece publicada la fotografía, ya que estos dos elementos, al margen de muchos más, nos amplían el aporte de la imagen para la construcción de memoria histórica, teniendo como referencia el caso y los medios de comunicación citados en el título.
Saída do segundo armário: análise das narrativas autobiográficas de Felipe Mastrandéa
Authors: Filho Robson Evangelista dos Santos , Procópio Xavier Mariana Ramalho
Published: August 2020

No presente artigo, apresentamos uma discussão sobre visibilização de temáticas da esfera do privado (SENNETT, 1988) e do segredo (SEDGWICK, 1990), por meio da análise de narrativas autobiográficas de Felipe Mastrandéa em seu canal no YouTube, em que o vlogger revela ser soropositivo. A partir dessa análise, objetivamos perceber como se dá a construção dessas videografias de si (COSTA, 2007; 2009), assim como a saída do chamado segundo armário (MISKOLCI, 2012a). Para tanto, recorremos a bibliografias sobre diários contemporâneos na internet e sobre o HIV e, uma vez que esse vírus, assim como outras questões relacionadas ao sexo, é alocado no âmbito do sigilo, principalmente em razão do estigma a ele atribuído historicamente, abordamos temas como público versus privado, exposição de intimidade e regimes de visibilidade, valendo-se das contribuições de Arfuch (2010), Bruno (2013), Sibilia (2003; 2016), Goulemot (2009), Ranum (2009), Foisil (2009), dentre outros autores. Como principais resultados, percebemos que as videografias são marcadas por um imbricamento do público e do privado. Neste caso específico, o domínio pessoal é publicizado com função estratégica, para adquirir visibilidade e manter um status de webcelebridade. No entanto, essa revelação é parcial, uma vez que Felipe Mastrandéa confere mais importância à exposição da identidade homossexual e menos à soropositividade. Além disso, contar que convive com HIV poderia ser utilizado por ele como um posicionamento contra discursos preconceituosos e discriminatórios, entretanto, o vlogger acaba, na contramão, reforçando os estereótipos relativos à promiscuidade e à irresponsabilidade.
Building Density Level of Urban Slum Area in Jakarta
Authors: Legarias Tenty Melvianti , Nurhasana Renny , Irwansyah Edy
Published: August 2020

Currently, the number of urban residents is increasing and some of the urban population live in slum areas. Therefore, identifying the characteristics of slum areas has become crucial. This study aimed to identify more specific slum locations in Jakarta through the pattern of building densities analysis between case studies of neighborhoods association (RT) in 15 hamlets (RW) that classified as heavy slums category. This study also attempted to determine the relation between building density levels in the slum area and Jakarta spatial detail planning. This study engaged the Cluster and Outlier Analysis (Anselin Local Moran's I) method. This study also observed socio-economic factors of citizen census data based the Dasawisma Census of Family Welfare Empowerment in 2019. The result shows that slum locations that had direct neighbors towards areas which was designated at spatial detail planning as industrial zones and ware housing areas as well as office, trade and service zones, obtained a higher level of building density compared to slum locations that secured neighbors to areas that were designated as housing zones. High economic opportunities provided attraction and affected the growth of slum locations. The results also reveal that slum areas were not a concentrated population with low income and/or low education. Applying cluster and outlier modeling of building density levels of urban slums in Jakarta based on RT cluster level could reveal more specific slum locations and could identify factors that influence the differences of building density levels.

Keywords: Slums; Spatial Detail Planning; Cluster and Outlier Analysis; Geographic Information System

 

Copyright (c) 2020 Geosfera Indonesia Journal and Department of Geography Education, University of Jember

This work is licensed under a Creative Commons Attribution-Share A like 4.0 International License
Analisis Perbandingan Metode Interior Gateway Protocol RIP Dengan OSPF Pada Jaringan MPLS-VPLS
Authors: Nurdiansyah Yanuar , Pratama Nail , Putra Muhammad Ifantara , Sya’roni Muhammad Ali
Published: August 2020

Routing is a process for forwarding network packets from one network such as static routing and dynamic routing. This research will evaluate and implement protocols in dynamic routing such as RIP (Routing Information Protocol) and OSPF (Open Short Path First). What will later be simulated with GNS3, from this study will be obtained results For traceroute, OSPF is about 7% faster than RIP time, while for ping, OSPF is 5.9% faster than RIP and for traceroute in the topology the average result of the average traceroute time is 2.58 for RIP and 2.23 for OSPF.
Implementasi Sistem Informasi Monitoring Kendaraan Dinas Terintegrasi Pada Bank Indonesia Lhokseumawe
Authors: Mutasar Mutasar , Hasdyna Novia , Arafat Akbar
Published: August 2020

A monitoring system is needed to monitoring vehicle’s daily activities at Bank Indonesia Lhokseumawe. The management of vehicle’s daily activities in the Representative Office of Bank Indonesia Lhokseumawe is still using manual handwritting’s records on some books, which is making it difficult to retrieve the required data quickly and accurately. To assist in carrying out the objection given, the authors designed an integrated information system which capable to monitoring vehicle’s daily activities. The Information system based on web and gps for android.
Analisis Matthew Correlation Coefficient pada K-Nearest Neighbor dalam Klasifikasi Ikan Hias
Authors: Hasdyna Novia , Dinata Rozzi Kesuma
Published: August 2020

K-Nearest Neighbor (K-NN) is a machine learning algorithm that functions to classify data. This study aims to measure the performance of K-NN algorithm by using Matthew Correlation Coefficient (MCC). The data that used in this study are the ornamental fish which consisting of 3 classes named Premium, Medium, and Low. The analysis results of the Matthew Correlation Coefficient on K-NN using Euclidean Distance obtained the highest MCC value in Medium class which is 0.786542. The second highest MCC value is in Premium class which is 0.567434. The lowest MCC value is in Low class which is 0.435269.

Overall, the MCC values is statistically which is 0,596415.
Analisis Keamanan Website Menggunakan Teknik Footprinting dan Vulnerability Scanning
Authors: Alwi Erick Irawadi , Herdianti Herdianti , Umar Fitriyani
Published: August 2020

Website security is an effort to protect websites from hacker attacks connected through a network. Website security needs to be a concern in the midst of many cases of website hacking from irresponsible people, including websites at Indonesian tertiary institutions that provide information and services to the public, students, and alumni of tertiary institutions.

Higher education institution websites that can be accessed widely online can create vulnerabilities against threats from hacker attacks. To minimize this vulnerability, it is necessary to test the website of the higher education institution to assess and evaluate the security system of the university's website. The research method used in this study is the Ethical Hacking method which focuses on footprinting techniques and vulnerability scanning by only testing passive attacks. The results of this study have found information related to the target website (the website of an educational institution in one of the cities in Indonesia) and several vulnerability alerts after testing vulnerability scanning with high to low risk levels so that researchers recommend improving vulnerability to minimize security holes exploited by hackers .
YIKICI SİSMİK YÜKLER ALTINDA SİLİNDİRİK ÇELİK SU TANKLARININ DOĞRUSAL OLMAYAN ANALİZİ
Authors: ÇELİK Ali İhsan , KÖSE M. Metin , AKGÜL Tahir , APAY Ahmet Celal
Published: August 2020

Silindirik
çelik sıvı tankları; su, petrol ve endüstriyel kimyasallar gibi çeşitli
sıvıları depolamak için yaygın olarak kullanılmaktadırlar. Ayrıca son yıllarda
nükleer enerji santrallerinde soğutma amaçlı kullanımları yaygınlaşmaktadır.
Çelik sıvı tanklarındaki petrol veya diğer tehlikeli kimyasallar, deprem esnasında
tanklarda oluşan hasarlar sebebi ile büyük finansal ve çevresel zarara neden
olabilmektedir. Önemli mühendislik yapıları olan bu tankların, doğal titreşim
periyotları 0,1 sn.- 0,5 sn. aralığındadır. Bu kısa periyotta meydana gelen
maksimum deprem enerjisinden dolayı tanklarda hasarlar oluşabilir. Bu çalışma
için, silindirik çelik tanklardaki deformasyonlar, burkulmalar çok kısa sürede meydana
geldiği için 0,22 saniyelik El-Centro deprem kaydı kullanılmıştır.  Bununla birlikte, yıkıcı ve kısa süreli
kuvvetler altında yapıların dinamik analizinde ANSYS Workbench “Explicit
Dynamics” aracı çok iyi sonuçlar verdiğinden, seçilen bu süre ve deprem verisi,
doğrusal olmayan analiz için ideal olmuştur. Su ve tank duvarı arasındaki etkileşimi
sağlamak için suyun modellenmesinde, “Eulerian Body” ağ yapısı tekniği, “Explicit Dynamics” aracında tercih
edilmiştir. Analizde üstü-açık tank modeli, üstü-konik model ve üstü-kubbe
şeklinde kapatılan model kullanılmış ve üç farklı cidar kalınlığı için
analizler tekrar edilmiştir. Tank cidar kalınlığına ve tankın kapak şekline
bağlı olarak, meydana gelen deformasyon ve burkulmaların sebepleri
irdelenmiştir. Analiz sonucunda, silindirik çelik sıvı tanklarının kubbe
şeklinde kapatılmasının deformasyonları ve burkulmaları azalttığı görülmüştür
STABILITY CRITERIA FOR RETARDED FUNCTIONAL DIFFERENTIAL EQUATIONS
Authors: YENİÇERİOĞLU Ali Fuat , YAZICI Cüneyt
Published: August 2020

In this work, we examine the stability behavior of retarded functional differential equations. The asymptotic behavior of solutions and stability of the zero solution are investigated by using a suitable real root for the characteristic equation. Three examples are also given to illustrate our results.In this work, we examine the stability behavior of retarded functional differential equations. The asymptotic behavior of solutions and stability of the zero solution are investigated by using a suitable real root for the characteristic equation. Three examples are also given to illustrate our results.In this work, we examine the stability behavior of retarded functional differential equations. The asymptotic behavior of solutions and stability of the zero solution are investigated by using a suitable real root for the characteristic equation. Three examples are also given to illustrate our results.
EFFECT OF PRESSURE AND VOLTAGE ON SPHERICAL PLASMA FOCUS DYNAMICS
Authors: AY Yaşar
Published: August 2020

A spherical plasma focus device with two concentric electrodes is simulated using equal amount of deuterium and tritium mixture as a working gas. The developed model is used to investigate the effect of gas pressure and charging voltage on dynamics of current sheath in spherical plasma focus. While charging voltage is varied from 15 kV to 30 kV to see the effect of voltage, gas pressure is increased from 1 Torr to 20 Torr for gas pressure study. In this work, it is found that there is a strong correlation between current sheath dynamics and investigated parameters which are gas pressure and charging voltage.
Revisiting Constraints of Fourth-Generation Quarks and Leptons
Authors: Verma Aayush
Published: August 2020

Standard Model is well-performing under the three-generation, but in the wake of more physics, fourth-generation leptons and quarks are introduced. In this paper, We will be reviewing various constraints surrounding quarks and leptons of 4th Generation and tried to show the importance of quarks to understand the baryogenesis. We talked about, reviewed existing parameters and set the updated lower limits of t’ and b’ by analysis. And predicted an updated version of lower mass bounds quarks and leptons. It is also reviewed that fourth generation leptons are primarily not possible because of disintegration of Higgs Boson and an interpretation has been setup. And in final, we talked about the Unified Standard Model.
The Early Silurian Gabbro in the Eastern Kunlun Orogenic Belt, Northeast Tibet: Constraints on the Proto-Tethyan Ocean Closure
Authors: Zhou Wenxiao , Li Haiquan , Chang Feng , Lv Xinbiao
Published: August 2020

The early Paleozoic is a crucial period in the formation and evolution of the Eastern Kunlun Orogenic Belt (EKOB), and is of great significance for understanding the evolutionary history of the Proto-Tethyan Ocean. This paper presents new petrography, geochemistry, zircon U–Pb dating, and Lu–Hf isotopic research on the Yuejingshan gabbro from the eastern segment of the EKOB. Zircon U–Pb data suggests that the gabbro formed in the Early Silurian (435 ± 2 Ma). All samples have relatively low TiO2 contents (0.45–2.97%), widely varying MgO (6.58–8.41%) and Mg# (58–65) contents, and are rich in large ion lithophile elements (LILE such as Rb, Ba, Th, and U) and light rare earth elements (LREE). This indicates that it has a similar geochemical composition to island arc basalt. The major element features indicate that the formation of this gabbro underwent fractional crystallization of clinopyroxene, olivine, and plagioclase. The depletion of high field strength elements (HFSE, such as Nb, Ta, and Ti), and a slightly positive Hf isotope (with εHf(t) ranging from 1.13 to 2.45) may be related to the partial melting of spinel-bearing peridotite, led by slab fluid metasomatism. The gabbro likely represents magmatic records of the latest period of the early Paleozoic oceanic crust subduction in the Eastern Kunlun. Therefore, the final closure of the Proto-Tethyan Ocean and the beginning of collisional orogeny occurred before the Early Silurian.
Root Traits and Architecture Affect Standard Litter Decomposition: A Comparative Study on Five Plant Species
Authors: Sofo Adriano , Elshafie Hazem S. , Camele Ippolito
Published: August 2020

Plants are affected by soil environments to the same extent they affect soil functioning through interactions between environmental and genetic factors. Here, five plant species (broad bean, pea, cabbage, fennel, and olive) grown under controlled pot conditions were tested for their ability to differently stimulate the degradation of standard litter. Litter, soil C and N contents and soil microbial abundance were measured. The architecture and morphological traits of roots systems were also evaluated by using specific open-source software (SmartRoot). Soil chemical and microbiological characteristics were significantly influenced by the plant species. Variations in soil C/N dynamics were correlated with the diversity of root traits among species. Early-stage decomposition of the standard litter changed on the basis of the plant species. The results indicated that key soil processes are governed by interactions between plant roots, soil C and N, and the microbial metabolism that stimulate decomposition reactions. This, in turn, can have marked effects on soil chemical and microbiological fertility, both fundamental for sustaining crops, and can promote the development of new approaches for optimizing soil C and N cycling, managing nutrient transport, and sustaining and improving net primary production.
Overview of Kaolin Outcomes from Vine to Wine: Cerceal White Variety Case Study
Authors: Dinis Lia-Tânia , Bernardo Sara , Matos Carlos , Malheiro Aureliano , Flores Rui , Alves Sandra , Costa Carina , Rocha Sílvia M. , Correia Carlos M. , Luzio Ana , Moutinho-Pereira José
Published: August 2020

Kaolin protective effect was assessed in a white grapevine cultivar ‘Cerceal’ in ‘Alentejo’ Region (southeast Portugal) where plants face extreme conditions during summer season. We addressed the hypothesis that kaolin effects lead to several changes in leaves, fruits and wine characteristics on the primary and secondary metabolism. Results showed that kaolin reduces leaf temperature which provoke an improvement in physiological parameters such as net photosynthesis and water use efficiency. This protection interferes with berries colour, leaving them more yellowish, and an increase in phenolic compounds were observed in all fruit tissues (skin, seed and pulp). Also, both berry and wine characteristics were strongly affected, with an increase of tartaric and malic acid and consequently high total acidity, while the sugar concentration decreased 8.9% in berries provoking a low wine alcohol level. Results also showed that kaolin induces high potassium, magnesium and iron, and low copper and aluminum concentrations. Moreover, the control wine showed higher content of esters related with hostile notes whereas wine from kaolin treated vines presented higher content of esters associated with fruity notes. Overall, the results strengthen the promising nature of kaolin application as summer stress mitigation strategy protecting grapevine plants and improving fruits quality and more balanced wines.
Maturation of Pseudo-nucleus Compartment in P. aeruginosa, Infected with Giant PhiKZ Phage
Authors: Danilova Yana , Belousova Viktoria V. , Moiseenko Andrey V. , Vishnyakov Innokentii E. , Yakunina Maria V. , Sokolova Olga S
Published: August 2020

Bacteria develop various defense mechanisms against stresses, including the bacteriophage infection. The giant phiKZ phage infection induced the appearance of a pseudo-nucleus inside the bacterial cytoplasm. Here, we used FISH, electron tomography and analytical electron microscopy to study the morphology of this unique nucleus-like shell and to demonstrate the distribution of phiKZ and bacterial DNA in infected P. aeruginosa cells. The maturation of the pseudo-nucleus was traced in short intervals for 40 min after infection. This study was accompanied by the identification of phiKZ and bacterial DNA by real-time RCR. We demonstrated that phage DNA that isolated from the cytoplasm during all infection stages were compacted within the pseudo-nucleus in a specific structure. Bacterial DNA was diminished in the course of infection, but did not completely degrade until at least 40 min after phage application. The content of the total phage DNA, on the other hand, increased. EDX analysis confirmed these results and revealed that, during the infection, Sulfur content in the bacterial cytoplasm increased, which suggests the increase of DNA-binding Met-reach proteins synthesis, which could protect bacterial DNA from stress.
Rapid Recovery in Six Patients with COVID-19 Respiratory Failure after Treatment with Vasoactive Intestinal Peptide
Authors: Javitt Jonathan , Youssef Jihad
Published: August 2020

Background: Vasoactive Intestinal Peptide (VIP) is known to bind to and protect the Alveolar Type II cell by blocking replication of the SARS-CoV-2 virus, upregulating surfactant production, blocking apoptosis, and blocking cytokine effects. RLF-100 (Aviptadil), a synthetic form of Vasoactive Intestinal Peptide (VIP) has been granted Fast Track Designation and is currently in phase 2/3 placebo-controlled trials. FDA has granted Emergency Use IND and Expanded Access Protocol approval for the use of RLF-100 in patients whose comorbidities render them ineligible for inclusion in the ongoing pivotal trial. Methods: This report describes the first 6 patients with Acute Respiratory Failure in Critical COVID-19, enrolled under Emergency Use IND were treated with three successive 12-hour infusions of intravenous Aviptadil at 50/100/150 pmol/kg/hr, while continuing to receive maximal ICU care. Results: Median patient follow-up time is 14 days. So far, all treated patients have survived. Improved radiographic appearance of typical “ground glass” COVID-19 features to varying degrees is seen in all patients within 72 hours. Improvement in blood oxygenation is seen in all patients, with complete remission from respiratory failure in 4 of 6 patients. An average 56% reduction in inflammatory markers was seen, together with a median 4 point reduction in the NIAID Ordinal Scale. 2/6 patients were discharged from the hospital and 1 patient was downgraded to the general medicine floor. Comment: The short term survival of 6/6 patients with respiratory failure in the setting of COVID-19 and major comorbidity is the most dramatic response ever seen with an antiviral agent. Improvement in radiographic appearance, oxygenation requirement, and inflammatory markers is consistent with in vitro evidence of direct anti-viral effect.
Brain Tumor Detection: 2 Novel Approaches
Authors: Kim Donghyun
Published: August 2020

In this paper, we propose 2 novel methods for brain tumor detection in MRI images. In the first proposed approach, we build upon prior research on ensemble methods by testing the concatenation of pre-trained models: features extracted via transfer learning are merged and segmented by classification algorithms or a stacked ensemble of those algorithms. In the second approach, we expand upon prior studies on convolutional neural networks: a convolutional neural network involving a specific module of layers is used for classification. The first approach achieved accuracy scores of 0.98 and the second approach achieved a score of 0.863, outperforming a benchmark VGG-16 model. Considerations to granular computing and circuit complexity theory are given in the paper as well.
Mean-Field Theory of the Meissner effect in Bulk Revisited
Authors: Banyai Ladislaus
Published: August 2020

We show that the implementation of the 1/c² transverse current-current interaction between elec- trons into the standard self-consistent electron BCS model in bulk under thermal equilibrium in the stable superconductive phase ensures the full compensation of a constant external magnetic field by the internal magnetic field created by the electrons.
Noisy Genome Data and Faulty Clade Statistics Undermine Conclusions on SARS-CoV-2 Evolution and Strain Typing in the Brazilian Epidemy: A Technical Note
Authors: Briones Marcelo R. S. , Antoneli Fernando , Ferreira Renata C. , Carvalho Isabel M. V. G. , Janini Luiz M. R.
Published: August 2020

We show that low quality of all 427 Brazilian SARS-CoV-2 genomes recently published in Science (1) challenges their phylogenetic inference and may lead to incorrect typing of viral strains in clades with no statistical support. Absence of basecalling quality in genome assemblies and proper phylogeny parameter estimates preclude the assessment of signal-to-noise ratio in the data, downstream analysis and conclusions.
Histological Analysis, Bioinformatics Profile, and Expression of Methylenetetrahydrofolate Reductase (MTHFR) in Bovine Testes
Authors: Afedo Seth Yaw , Cui Yan , Yu Sijiu , Liao Bo , Zhao Zihan , Li Hui , Zhang Huizhu , Zou Shengnan , Li De Hong , Zhang Peng
Published: August 2020

Methylenetetrahydrofolate reductase (MTHFR), an enzyme expressed in mammalian testes exerts direct effect on spermatogenesis; however, its protein characteristics in bovine testes remain unknown. Here, we analysed bovine testicular structure, MTHFR bioinformatics profile, mRNA, and protein expression characteristics in yellow-cattle (y-c) and yak testis using histological procedures, bioinformatics analysis, qRT-PCR, and western blot. Testes from 13 bovines, ≤ 2 years juvenile (y-c, n = 3; yak, n=3) and ≥ 3 years adult (y-c, n = 3; yak, n = 4) were collected and analysed. Anatomical characteristics of testis in y-c and yak were similar except the weight or size for which that of y-c was significantly higher or greater than yak. In y-c, an open reading frame (ORF) for 2600 nucleotides sequence, encoding 655 amino acids showed high homology with zebu cattle (99.51%) and wild yak (98.68%). Secondary and 3D protein structures were similar to that of humans with differences in number of nucleotides, amino acids, and some physico-chemical characteristics. MTHFR mRNA expression in y-c and yak were significantly higher in adult testes compared with juvenile ones. However, its protein expression was higher but not statistically significant in adult y-c and yak compared to the juvenile ones. The highlights and inferences of these and other findings are discussed.
Diagnosis of Breakthrough Fungal Infections in the Clinical Mycology Laboratory: An ECMM Consensus Statement
Authors: Jenks Jeffrey D. , Gangneux Jean-Pierre , Schwartz Ilan S. , Alastruey-Izquierdo Ana , Lagrou Katrien , Thompson III George R. , Lass-Florl Cornelia , Hoenigl Martin
Published: August 2020

Breakthrough invasive fungal infections (bIFI) cause significant morbidity and mortality. Their diagnosis can be challenging due to reduced sensitivity of conventional culture techniques, serologic tests, and PCR-based assays in patients on antifungal therapy, and their diagnosis can be delayed contributing to poor patient outcomes. In this review, we provide consensus recommendations on behalf of the European Confederation for Medical Mycology (ECMM) for the diagnosis of bIFI caused by invasive yeasts, molds, and endemic mycoses, to guide diagnostic efforts in patients receiving antifungals and support the design of future clinical trials in the field of clinical mycology. The cornerstone of lab-based diagnosis of breakthrough infections for yeast and endemic mycoses remain conventional culture, to accurately identify the causative pathogen and allow for antifungal susceptibility testing. The impact of non-culture-based methods are not well-studied for the definite diagnosis of breakthrough invasive yeast infections. Non-culture-based methods have an important role for the diagnosis of breakthrough invasive mold infections, in particular invasive aspergillosis, and a combination of testing involving conventional culture, antigen-based assays, and PCR-based assays should be considered. Multiple diagnostic modalities, including histopathology, culture, antibody and/or antigen tests and occasionally PCR-based assays may be required to diagnose breakthrough endemic mycoses. A need exists for diagnostic tests that are effective, simple, cheap, and rapid to enable the diagnosis of bIFI in patients taking antifungals.
Pulmonary Embolism Related to COVID 19 Quarentine
Authors: Quinteros Eduardo , Bisonni Juan
Published: August 2020

The quarantine imposed as the response to the COVID 19 pandemic has been related to an increase in cases of thromboembolism in Non-COVID19 patients .We report the case of a patient with pulmonary thromboembolism without usual triggering causes during the quarantine period, related to a previously undiagnosed hypercoagulable condition.
Improvement of Ficin-Based Inhibitive Enzyme Assay for Mercury Using Response Surface Methodology and Its Application for Near Real-Time Monitoring of Mercury in Marine Waters
Authors: Uba Garba , Manogaran Motharasan , Gunasekaran Baskaran , Halmi Mohd Izuan Effendi , Shukor Mohd Yunus Abd
Published: August 2020

Heavy metals pollution in the Straits of Malacca warrants the development of rapid, simple and sensitive assays. Enzyme-based assays are excellent preliminary screening tool with near real-time potential. The heavy-metal assay based on the protease ficin was optimized for mercury detection using Response Surface Methodology. The inhibitive assay is based on ficin action on the substrate casein and residual casein is determined using the Coomassie dye-binding assay. Heavy metals strongly inhibit the hydrolysis. A Central Composite Design (CCD) was utilized to optimize detection. The results show a marked improvement for the concentration causing 50% inhibition (IC50) for mercury, silver and copper. Compared to One-factor-at-a-time (OFAT) optimization, RSM gave an improvement of IC50 from 0.060 (95% CI, 0.0300.080) to 0.017 (95% CI, 0.0160.019), from 0.098 (95% CI, 0.0770.127) to 0.028 (95% CI, 0.0220.037) and from 0.040 (95% CI, 0.035.045) to 0.023 (95% CI, 0.0200.027), for mercury, silver and copper, respectively. A near real-time monitoring of mercury concentration in the Straits of Malacca at one location in Port Klang was carried out over a 4-h interval for a total of 24 h and validated by instrumental analysis with the result revealing an absence of mercury pollution in the sampling site.
Virtual Screening of Marine Natural Compounds by Means of Chemoinformatics and CDFT-Based Computational Peptidology
Authors: Flores-Holguín Norma , Frau Juan , Glossman-Mitnik Daniel
Published: August 2020

This work presents the results of a computational study of the chemical reactivity and bioactivity properties of the members of the Theopapuamides A-D family of marine peptides by making use of our own proposed methodology named Computational Peptidology (CP) that has been successfully considered in previous studies of this kind of molecular systems. CP allowed for the determination of the global and local descriptors that come from Conceptual Density Functional Theory (CDFT) that can give an idea of the chemical reactivity properties of the marine natural products under study which are already known to be related to their bioactivity. At the same time, the validity of the procedure based on the adoption of the KID (Koopmans in DFT) technique as well as the MN12SX/Def2TZVP/H2O model chemistry has been successfully verified. Together with several Chemoinformatic tools that can be used for the improvement of process of Virtual Screening, some additional properties of these marine peptides were identified related to their ability to behave as useful drugs. With the further object of analyzing their bioactivity some parameters of usefulness for future QSAR studies, their predicted biological targets and the the ADMET (Absorption, Distribution, Metabolism, Excretion and Toxicity) parameters related to the Theopapuamides A-D pharmacokinetics are also reported.
SARS-CoV-2 Infection Reaches the Human Nervous System: How?
Authors: Uversky Vladimir N. , Elrashdy Fatma , Aljadawi Abdullah , Ali Syed Moasfar , Khan Rizwan Hasan , Redwan Elrashdy M.
Published: August 2020

Without protective and/or therapeutic agents the SARS-CoV-2 infection known as coronavirus disease 2019 (COVID-19) is quickly spreading worldwide. It has surprising transmissibility potential, since it could infect all ages, gender, and human sectors. It attacks respiratory, gastrointestinal, urinary, hepatic, and endovascular systems and can reach the peripheral nervous system (PNS) and central nervous system (CNS) through known and unknown mechanisms. The reports on the neurological manifestations and complications of the SARS-CoV-2 infection are increasing exponentially. Herein, we enumerate seven candidate routes, which the mature or immature SARS-CoV-2 components could use to reach the CNS and PNS, utilizing the within-body crosstalk between organs. The majority of SARS-CoV-2 infected patients suffer from some neurological manifestations (e.g., confusion, anosmia, and ageusia). It seems that although the mature virus did not reach the CNS or PNS of the majority of patients, its unassembled components and/or the accompanying immune-mediated responses may be responsible for the observed neurological symptoms. The viral particles and/or its components have been specifically documented in endothelial cells of lung, kidney, skin, and CNS. This means that the blood-endothelial-barrier may be considered as the main route for SARS-CoV-2 entry into the nervous system, with the barrier disruption being more logical than barrier permeability, as evidenced by postmortem analyses.
Saccharomyces Cerevisiae an Interesting Producer of Bioactive Plant Polyphenolic Metabolites
Authors: Chrzanowski Grzegorz
Published: August 2020

Secondary phenolic metabolites are defined as valuable natural products synthesized by different organisms that are not essential for growth and development. These compounds play an essential role in plant defense mechanisms, and an important role in the pharmaceutical, cosmetics, food, and agricultural industries. Despite the vast chemical diversity of natural compounds, their content in plants is very low, in consequence, it eliminates the possibility of the production of these interesting secondary metabolites from plants. Therefore, microorganisms are widely used as cell factories by industrial biotechnology to the production of different non-native compounds. Among microorganisms commonly used in biotechnological applications, yeasts are prominent host for the diverse secondary metabolite biosynthetic pathways. Saccharomyces cerevisiae is often regarded as the better host organism for the heterologous production of phenolics compounds, especially if the expression of different plant genes is necessary.
Construction of the Type 2 Degenerate Multi-Poly-Euler Polynomials and Numbers
Authors: Khan Waseem Ahmad , Acikgoz Mehmet , Duran Ugur
Published: August 2020

In this paper, we consider a new class of polynomials which is called the multi-poly-Euler polynomials. Then, we investigate their some properties and relations. We provide that the type 2 degenerate multi-poly-Euler polynomials equals a linear combination of the degenerate Euler polynomials of higher order and the degenerate Stirling numbers of the first kind. Moreover, we provide an addition formula and a derivative formula. Furthermore, in a special case, we acquire a correlation between the type 2 degenerate multi-poly-Euler polynomials and degenerate Whitney numbers.
Comparative Study of the Restorative Effects of Forest and Urban Videos during Covid-19 Lockdown: Intrinsic and Benchmark Value
Authors: Zabini Federica , Albanese Lorenzo , Becheri Francesco Riccardo , Gavazzi Gioele , Giganti Fiorenza , Giovanelli Fabio , Gronchi Giorgio , Guazzini Andrea , Laurino Marco , Li Qing , Marzi Tessa , Mastorci Francesca , Meneguzzo Francesco , Righi Stefania , Viggiano Maria Pia
Published: August 2020

The prolonged lockdown imposed to contain the COVID-19 pandemic prevented many people from direct contact with nature and greenspaces, raising alarms for a possible worsening of mental health. This study investigates the effectiveness of a simple and affordable remedy for improving psychological well-being, based on audio-visual stimuli brought by a short computer video showing forest environments, with an urban video as a control. Randomly selected participants were assigned the forest or urban video, to look at and listen early in the morning, and filled questionnaires. In particular, the State-Trait Anxiety Inventory (STAI) Form Y, collected in baseline condition and at the end of the study, and the Part II of the Sheehan Patient Rated Anxiety Scale (SPRAS), collected every day immediately before and after watching the video. The virtual exposure to forest environments showed effective to reduce perceived anxiety levels in in people forced by lockdown in limited spaces and environmental deprivation. Although significant, the effects were observed only in the short term, highlighting the limitation of the virtual experiences. The reported effects might also represent a benchmark to disentangle the determinants of health effects due to real forest experiences, for example, the inhalation of biogenic volatile organic compounds (BVOC).
Transcriptomic Analysis of Streptococcus suis in Response to Ferrous Iron and Cobalt Toxicity
Authors: Jia Mengdie , Wei Man , Zhang Yunzeng , Zheng Chengkun
Published: August 2020

Streptococcus suis is a zoonotic pathogen causing serious infections in both swine and humans. Although metals are essential for life, excess amounts of metals they are toxic to bacteria. when accumulated in excess amounts. Except for zinc, Transcriptome-level data of the mechanisms for resistance to metal-induced toxicity in S. suis are available for no metals other than zinc. have not been investigated from the transcriptome level in S. suis. Herein, we explored the transcriptome-level changes of in S. suis in response to ferrous iron and cobalt toxicity by RNA sequencing. Many A lot of genes were differentially expressed in the presence of excess ferrous iron and cobalt. Most of the genes in response to cobalt toxicity showed the same expression trends as those were expressed in the same trend in response to ferrous iron toxicity. qRT-PCR analysis of the selected genes confirmed the accuracy of RNA sequencing results. Bioinformatics analysis of the differentially expressed genes indicated that ferrous iron and cobalt have similar impacts effects on the cellular processes of S. suis. Treatment with ferrous Ferrous iron treatment resulted in down-regulation of several oxidative stress tolerance-related genes involved in oxidative stress tolerance and up-regulation of the genes in an amino acid ABC transporter operon. Expression of the several genes in the arginine deiminase system was down-regulated in the presence of after ferrous iron and cobalt treatment. Collectively, our results suggested that S. suis alters the expression of a lot of multiple genes to respond to ferrous iron and cobalt toxicity.
Pengaruh Model Pembelajaran Inkuiri Terbimbing dengan Pendekatan Berbasis Kontekstual (CBA) terhadap Literasi Kimia Peserta Didik Kelas XI MIPA SMA Negeri Jakarta pada Materi Hidrolisis Garam
Authors: Ade Mutia  , Hadinugrahaningsih Tritiyatma , Budi Setia
Published: August 2020

Penelitian ini bertujuan untuk mengetahui pengaruh positif model pembelajaran inkuiri terbimbing dengan pendekatan berbasis kontekstual (CBA) terhadap literasi kimia peserta didik kelas XI MIPA SMA Negeri Jakarta pada materi hidrolisis garam. Penelitian dilakukan pada semester genap tahun ajaran 2018/2019. Metode penelitian yang digunakan adalah quasi-experiment dengan menggunakan the post-test only non-equivalent design. Sampel penelitian berjumlah 64 peserta didik kelas XI MIPA C (kelas kontrol) dan XI MIPA D (kelas eksperimen) yang dipilih dengan teknik purposive sampling. Instrumen posstest digunakan untuk mengukur tingkat literasi kimia peserta didik pada materi hidrolisis garam. Hasil penelitian menunjukkan bahwa kemampuan literasi kimia peserta didik kelas eksperimen 60,84% dengan kategori sedang sedangkan kemampuan literasi kimia kelompok kontrol 50,82% dengan kategori rendah. Berdasarkan perhitungan uji beda dengan Independent Sample T-test (α = 0,05) diperoleh nilai thitung (2,597) > ttabel (1,669). Berdasarkan hasil analisis penelitian dapat disimpulkan bahwa terdapat pengaruh positif pada penerapan model pembelajaran inkuiri terbimbing dengan pendekatan berbasis kontekstual (CBA) terhadap literasi kimia peserta didik kelas XI MIPA SMA Negeri Jakarta pada materi hidrolisis garam.

Kata kunci: Inkuiri Terbimbing, Pendekatan Kontekstual (CBA), Literasi Kimia, Hidrolisis Garam.
Egoism Seems Self- Destructive
Authors: Boro Alidou Razakou Ibourahima , Emile TONOUEWA Mèdessè , Alexis SEGUEDEME
Published: August 2020

Being brought up under certain circumstances, a child may become an egoist. If he is not capable to adjust himself to some situations, he may destroy himself by certain unpleasant problems. In George Eliot's novel Daniel Deronda, Gwendolen, an inborn egoist is not probably able to cope with some situations mainly after her marriage. As a matter of fact, she has been increasingly arrogant, rebellious, heartless, disapproving, unhappy. Under such a situation she has contributed to her husband, Grandcourt’s drowning.  Obviously, after her husband’s death, her future is dark for her. so, it can be admitted that she has ruined herself.
The Study of Chinese to English (C-E) Translation of Chinese Network Fantasy Novel from the Perspective of Eco-translatology: A Case Study on Battle Through the Heavens
Authors: Qianting Zhang
Published: August 2020

Taking the English version of Dou Po Cang Qiong as the research object, guided by Hu Gengshen’s eco-translatology theory, the study analyzes how the translator adapted to the eco-environment of the C-E translation. The conclusions are as follows: the translator adapted to the eco-environment by adding logical connectors, taking omit means, combining sentences, paying attention to cultural-loaded words, highlighting or obscuring cultural information, and adjusting the information density. The translator’s strategies can effectively convey the features of Chinese network fantasy novels which may help other translators when they translate similar genre novels.
Pedagogical Content Knowledge and Industrial Design
Education

Authors: Phillips Kenneth R. , De Miranda Michael A. , Shin Jinseup “Ted”
Published: August 2020

Pedagogical content knowledge (PCK) has been embraced by many of the recent
educational reform documents as a way of describing the knowledge possessed by expert
teachers. These reform documents have also served as guides for educators to develop
models of teacher development. However, in the United States, few if any of the current
models accurately address the role of PCK in the development of industrial design
educators. This article introduces the concept of PCK and how a taxonomy of essential
industrial design subject matter can be organized to serve as a content guide. The PCK
model presented could serve as a catalyst for the field of industrial design education
to produce a conceptual framework and taxonomy for the teaching of industrial design
upon which future PCK studies in industrial design education can be based. These
conceptual frameworks (or taxonomies) help within a field to articulate the core
knowledge, skills, and dispositions that define practice. The interaction of teacher
content knowledge in industrial design, pedagogical knowledge, and context of industrial
design is framed within a PCK taxonomy.
Implementation of Environmental Care Education from Early Age
Authors: Intishar Sarisawati , Azzahro Fathia Zaitun , Aris Ismi Hidayati , Syukrotus Syukrotus , Isnawati Zakiyah , Hidayatullah Ahmad Fauzan
Published: August 2020

Environmental sustainability is a sensitive issue lately due to increased global warming, erratic weather, disturbed ecosystems, the emergence of diseases, and so on. Garbage, the beginning of environmental damage in the air, water, and soil. All alternative pathways to protect the environment will be in vain if it is not balanced with an attitude of caring for the environment. The aim is to provide education and information about the importance of environmental sustainability to young children. The research method is a literature review of research journal articles related to the application of environmental education from an early age. In the research, it is known that in general the productive age that plays a role in environmental problems range from 15-64 years. The introduction and character education of caring for the environment is an effort to help children to always care about the environment and protect nature. The character of caring for the environment needs to be instilled from an early age in order to be able to love the environment. Good behavior starts from simple activities since I was a child, because at this time the brain can quickly absorb all the information obtained. When in previous studies environmental character education is integrated with each subject through competency standards, active learning, and school culture. This study focuses on environmental sustainability character education in early childhood.