bluuebunny/crossref_metadata_2025 huggingface dataset:
Successful management of a 7-year-old-female with juvenile dermatomyositis at a tertiary hospital in low-income country
Authors: Wulandari Desy , Lubis Azwin Mengindra Putera , Hikmah Zahrah , Endaryanto Anang
Published: January 2025

Juvenile dermatomyositis (JDM) is a rare chronic autoimmune disease belonging to idiopathic inflammatory myopathies. Pathological skin lesions and proximal weakness primarily characterize this entity,  but  clinical symptoms can be  heterogeneous.   Children   are   more   likely   to   have   long-term   complications   such   as lipodystrophy, calcinosis, and vasculopathy. Calcinosis is one of the characteristic sequelae of JDM, despite recent advances in the treatment of JDM, about one-third of patients still develop dystrophic calcinosis. In low-income countries, the availability of medicines is very limited. In our case, a 7-year-old female diagnosed with JDM presented with calcinosis. Aggressive and adequate treatment with steroids, methotrexate, hydroxychloroquine, and aluminium hydroxide can treat the complications. It is challenging to establish an early diagnosis, treatment, prevention of long-term complications, and improved prognosis of JDM, which then will improve the patient’s quality of life, especially in low income countries with limited drug availability.
Biofilm Profile of Coagulase Negative Staphylococci Bacteria from Milk Isolate of Dairy Cows with Subclinical Mastitis
Authors: Herman Nadissa Alika Rahma , Sarasati W , Adi I C
Published: January 2025

Staphylococcus sp. is a pathogenic bacteria that causes subclinical mastitis. These bacteria are divided into coagulase-negative Staphylococci (CoNS) and coagulase-positive Staphylococci (CoPS). CoNS bacteria are a group of normal flora on human and animal skin. However, several studies have proven that CoNS bacteria are the most commonly isolated microorganisms from the milk of dairy cows with subclinical mastitis. The ability to form biofilms is an important virulence factor for CoNS bacteria. Detection of biofilm formation was carried out on 54 samples of CoNS bacteria in the form of Stored Biological Material (BBT), which were isolated from the milk of dairy cows with subclinical mastitis with positive California mastitis test (CMT) 2 (++). Detection of biofilm formation was performed qualitatively by Congo red agar (CRA) and test tube (TT) methods. Phenotypic confirmation results showed that 54 isolates (100%) were CoNS bacteria. Biofilm formation detection results showed that 51 out of 54 isolates (94.44%) were positive for biofilm formation. Thus, it can be concluded that CoNS bacteria have the ability to form biofilms as a form of self-protection and virulence factor.
Transformation of Boarding School Management Models in Enhancing Student Accessibility and Educational Quality
Authors: Darwanto Agus , Prahmana Rully Charitas Indra , Susanti Ani , Khalil Ibrahim Alhussain
Published: January 2025

Purpose – Boarding schools in Indonesia integrate Islamic religious education with general education, offering a comprehensive learning and living experience for students. This model is effective in character building, moral value reinforcement, tolerance promotion, social integrity, and responsibility, all while emphasizing knowledge and technology mastery. However, these schools face challenges, including high costs, geographical barriers, and stringent academic requirements that limit accessibility for some students. This research underscores the need for management transformation in boarding schools to enhance accessibility and education quality while preserving the unique values and identity of pesantren.
Design/methods/approach – Utilizing a literature review methodology, this study critically summarizes and evaluates relevant research to provide a comprehensive understanding of the transformation of boarding school management in Indonesia.
Findings – The findings indicate that boarding schools must adapt to socio-cultural contexts and incorporate information and communication technology into management and learning processes. The study also reveals that parental involvement, effective management, and support for students' mental and physical health are crucial for the success of boarding schools.
Research implications/limitations – Future research should focus on integrating ICT to improve educational outcomes and administrative efficiency, assessing holistic education models, evaluating economic empowerment programs, and examining mental health initiatives, as well as exploring collaborative efforts to enhance community engagement and support for students.
Originality/value – Strengthening pesantren culture can address issues such as bullying, poor nutrition, and financial difficulties. Transformational management practices can meet the evolving educational needs and dynamic desires of parents and students while maintaining the core values of pesantren in Indonesia.
TÜRKİYEDE GÖRME ENGELLİ ÖĞRENCİLERE MERKEZİ SINAVLARDA MATEMATİK ALANINDA YAPILAN UYGULAMALARIN İNCELENMESİ
Authors: Yıldırım Hasan Hüseyin , Cakmak Salih
Published: January 2025

Bu çalışmada, ilgili araştırmalar çerçevesinde Türkiye’de görme engelli öğrencilere merkezi sınavlarda matematik alanında yapılan uygulamaların incelenmesi amaçlanmıştır. Çalışmada ilk olarak görme engelli öğrencilerin özellikleri ve onlara verilen matematik öğretimine ilişkin kuramsal çerçeveye yer verilmiş; ikinci olarak, merkezi sınavlarda görme engelli öğrencilere yönelik matematik sorularında yapılan uyarlama ve uygulamalar tanıtılmıştır. Üçüncü olarak ise merkezi sınavlarda görme engelli öğrencilerin birtakım matematik sorularından muaf tutulmasındaki sorunlar irdelenmiş, incelenen araştırma bulguları sunulmuş ve bunlar ilgili literatür çerçevesinde tartışılmıştır. Son olarak, literatür doğrultusunda Türkiye’de görme engelli öğrencilerin matematik alanında merkezi sınavlarda muaf tutulma durumlarına ve yapılan uygulamalara yönelik araştırma ve uygulama önerilerinde bulunulmuştur.
Struktur Percakapan Host Utama Dalam Talk Show Oshareizumu
Authors: Fitriyany Elsy , Hidayati Yanti , Syukur Andi Abd Khaliq
Published: January 2025

This research analyzes the conversational structure of the main host in the talk show "Oshareizumu." The primary focus is on the speaking style and interaction strategies used by the main host, Ueda. A pragmatic approach is employed as the theoretical framework, referencing the theories of Yule (2014) and Lidia Tanaka (2014). This study identifies three instances of pauses, three instances of overlap, and one hundred and nineteen occurrences of backchannel or aizuchi. Ueda's intensive and active speaking style demonstrates a high level of involvement in interactions. The results show that Ueda performs his role effectively, as evidenced by a conversational structure with minimal pauses and overlaps, extensive use of backchannel, and an intensive speaking style. These findings suggest that Ueda's contributions significantly enhance the attractiveness of the talk show.
KESANTUNAN TINDAK TUTUR DALAM PANDUAN MITIGASI BENCANA G EMPA BUMI JEPANG
Authors: Martawijaya Asteria Permata , Gustini Maria , Fathurahman Fajar
Published: January 2025

This study aims to describe the politeness of representative speech acts and directive speech acts used in NPO-Volcano’s disaster mitigation guideline materials. The method used on this research is descriptive method with data classification based on Searle (1979)’s illocutionary speech acts category and Brown & Levinson (1987)’s politeness scale of speech acts. On the NPO-Volcano disaster mitigation guide material found 41 data of the representative speech acts, which were used for (1) the stating function, (2) the speculating function, (3) the informing function, (4) the mentioning function, (5) the explaining function, and (6) the suggesting function. For the directive speech acts, 30 data were found, which were divided into three types of speech functions, the command function that used in form of ~verb e, ~te kudasai, ~mashou, the inviting function and the prohibiting function. Furthermore, when analyzed using Brown and Levinson's (1987) Politeness Theory, the representative and directive speech acts in the NPO-Volcano disaster mitigation material guide is using “bold on record” and “negative politeness” type of Brown and Levinson's (1987) politeness theory. The forms of negative politeness used are: the use of indirect expressions, respectful language, impersonalization and nominalization.
Studi Lanskap Linguistik: Bilingualisme dan Multilingualisme pada Papan Penamaan Bisnis Kuliner Jepang di Kota Malang Jawa Timur
Authors: Devina Nadia Irma Della , Khasanah Ismatul , Sugiharyanti Eni
Published: January 2025

This research focuses on the phenomena of bilingualism and multilingualism that reflected in the name boards for Japanese culinary businesses in Malang City especially in Lowokwaru District as the data sources of this study. In line with these data sources, the linguistic landscape theory of Laundry & Bourhis (1997) is used to analyze the phenomena that occur. The research method used is a descriptive qualitative method. The results of this study found 9 data in the form of Japanese culinary business naming boards in Lowokwaru sub-district consisting of 6 bilingual data (Japanese-English), 2 bilingual data (Japanese-Indonesian) and 1 multilingual data consisting of (Japanese-English-Javanese). The use of foreign languages on culinary business signboards is a reflection of the reality of symbolic functions and informative functions related to the mindset of people who feel that the use of foreign languages is a form of modernity, has a selling point and more attractive.Keywords: Linguistic Landscape, Japanese Culinary Businesses, Bilingualism, Multilingualism
Neural Differentiation Potentiated by the Leukaemia Inhibitory Factor through STAT3 Signalling in Mouse Embryonal Carcinoma Cells
Authors: Pacherník Jiří , Horváth V. , Kubala L. , Dvořák P. , Kozubík A. , Hampl A.
Published: January 2025

LIF is a cytokine playing a key role in the regulation of self-renewal and maintenance of undifferentiated state in mouse ES cells. The response of pluripotent cells to LIF is mediated mainly by the STAT3 and ERK signalling pathways. Recently, we have shown that LIF potentiated retinoic acid-induced neural differentiation of pluripotent mouse embryonal carcinoma P19 cells. Here we demonstrate that pro-neural effects of LIF and partially also of retinoic acid are abolished by inhibition of the JAK2->STAT3 signalling pathway. In contrast, inhibition of the MEK1->ERK signalling pathway does not exhibit any effect. These results suggest that in neurogenic regions, cooperative action of LIF and other neuro-differentiation-inducing factors, such as retinoic acid, may be mediated by the STAT3 signalling pathway.
Modulation of the Oxidative Stress and Nuclear Factor κB Activation by Theaflavin 3,3’-gallate in the Rats Exposed to Cerebral Ischemia-Reperfusion
Authors: Cai F. , Li C. , Wu Jiliang , Min Q. , Ouyang C. , Zheng M. , Ma S. , Yu W. , Lin F.
Published: January 2025

The major pathobiological mechanisms of IR injury include excitotoxicity, oxidative stress, and inflammation. TF3, a major constituent of black tea, possesses biological functions such as anti-oxidative and anti-inflammatory activities. The purpose of this study was to verify the neuronal protective potential of TF3 and its mechanisms against cerebral IR injury in rats. TF3 administration (10 and 20 mg.kg−1) ameliorated the infarct volume. TF3 also decreased the content of MDA and NO. TF3 significantly increased the activity of SOD and GSH-Px, which were reduced by IR injury. Administration of TF3 decreased mRNA and protein expression of COX-2 and iNOS. DNA binding and Western blotting revealed an increase in NF-κB activation and IκB depletion in IR brain tissue. Pretreatment with TF3 markedly inhibited IR-induced increase in nuclear localization of NF-κB, and preserved IκB in the cytoplasm. The results show that TF3 exerts protective effects against cerebral IR injury by reducing oxidative stress and modulating the NF-κB activation.
KCNJ11 E23K Polymorphism and Diabetes Mellitus with Adult Onset in Czech Patients
Authors: Čejková Pavlína , Novota P. , Černá M. , Kološtová K. , Nováková D. , Kučera P. , Novák J. , Anděl M. , Weber P. , Ždárský E.
Published: January 2025

In this work, we studied the association of the E23K polymorphism of the Kir6.2 ATP-sensitive potassium channels in 212 Czech patients with diabetes mellitus who were diagnosed after the age of 35. Patients were classified into T1DM, LADA and T2DM groups based on C-peptide and GADA levels. Carriers of the predisposing Kir6.2 E23K K allele showed no increased risk of either type of diabetes mellitus development. On the other hand, we found a correlation between E23K SNP of the KCNJ11 gene and C-peptide levels, which may be considered a measure of pancreatic β-cell activity, although this correlation was not statistically significant. In conclusion, we failed to confirm the Kir6.2 E23K as a genetic marker for T1DM, LADA and T2DM in the Central Bohemian population of the Czech Republic.
Nonlinear elliptic equations with self-adjoint integro-differential operators and measure data under sign condition on the nonlinearity
Authors: Klimsiak Tomasz
Published: January 2025

We study the existence problem for semilinear equations (E): −Au = f(⋅, u) + μ, with Borel measure μ and operator A that generates a symmetric Markov semigroup. We merely assume that the nonlinear part f is a Carathéodory function satisfying the so-called sign condition. We extend the method of sub and supersolutions for (E) and prove that if such exist, then there exists a solution to (E) (we do not even assume that the subsolution is less than or equal to the supersolution!). We further show that for any μ there exists a unique metric projection

μ

̂

$\hat{\mu }$

of μ onto the set of good measures, i.e. Borel measures for which there exists a solution to (E).
Follow-up contributions for collaboratively accomplishing peer feedback in video-mediated L2 interactions
Authors: Ekşi Kübra , Can Daşkın Nilüfer
Published: January 2025

A micro-level analysis of second language (L2) peer feedback interactions specifically aimed at improving interactional abilities is lacking. Drawing on multimodal Conversation Analysis to examine 20 h of screen-recorded interactions of L2 learners in a video-mediated study group setting, this study demonstrates that in the collaborative accomplishment of L2 feedback in talk-in-interaction, peers’ follow-up contributions expand others’ feedback turns and open up space for further sequences of talk simultaneously. The follow-up contributions are realized through four interactional practices: (1) advising, (2) reformulating, (3) counterclaiming and (4) clarification-seeking. It is through such follow-up contributions that L2 learners change speakership, build turns contingent on previous contributions, perform diverse social actions, from resisting to clarifying, display their understanding and contribute to the ongoing feedback talk. We argue that being able to produce follow-up contributions is a crucial part of one’s L2 Interactional Competence (IC) and becomes a valuable interactional practice in securing intersubjectivity among the participants. The findings inform L2 language pedagogies about increasing learners’ sensitivity to the intricacies of dialogic and collaborative feedback talk from a micro-analytic perspective.
Behind the scenes of EQA – characteristics, capabilities, benefits and assets of external quality assessment (EQA)
Authors: Buchta Christoph , Marrington Rachel , De la Salle Barbara , Albarède Stéphanie , Badrick Tony , Bietenbeck Andreas , Bullock David , Cadamuro Janne , Delatour Vincent , Dusinovic Enes , Geilenkeuser Wolf-Jochen , Gidske Gro , Griesmacher Andrea , Haliassos Alexander , Holzhauser Derek , Huggett Jim F. , Karathanos Serafeim , Pezzati Paola , Sandberg Sverre , Sarkar Aditi , Solsvik Anne Elisabeth , Spannagl Michael , Thelen Marc , Restelli Veronica , Perrone Lucy A.
Published: January 2025

This is the first in a series of five papers that detail the role and substantial impact that external quality assessment (EQA) and their providers‘ services play in ensuring in-vitro diagnostic (IVD) performance quality. The aim is to give readers and users of EQA services an insight into the processes in EQA, explain to them what happens before EQA samples are delivered and after examination results are submitted to the provider, how they are assessed, what benefits participants can expect, but also who are stakeholders other than participants and what significance do EQA data and assessment results have for them. This first paper presents the history of EQA, insights into legal, financing and ethical matters, information technology used in EQA, structure and lifecycle of EQA programs, frequency and intensity of challenges, and unique requirements of extra-examination and educational EQA programs.
Impact of cholesterol in encapsulated vitamin E acetate within cocoliposomes
Authors: Hudiyanti Dwi , Hidayati Salma Nur , Siahaan Parsaoran , Ngadiwiyana Ngadiwiyana , Nur Abidin , Sari Ratna Indria , Amalia Indrian Rizka , Christa Sherllyn Meida , Patrechia Amanda Chindy , Maharani Adinda Eka
Published: January 2025

Vitamin E acetate (VEA) is commonly used in manufacturing pharmaceuticals, food additives, and animal feeds. However, VEA possesses disadvantages, including low water solubility, low bioavailability, and susceptibility to degradation and oxidation. This study investigated the use of cocoliposomes for encapsulating VEA (VEACL). The cocoliposomes consisted of coconut phospholipids (CocoPLs) and cholesterol (Chol). Several parameters, such as functional groups, transition temperature, encapsulation efficiency (EE), release profile, particle size, polydispersity index, and zeta potential, were analyzed to evaluate the impact of cholesterol inclusion on the cocoliposome membrane. The results show that the Fourier transform infrared spectra of VEACL do not exhibit any new, distinct peaks that differ from the peaks of its constituent composition. Therefore, it confirmed that no chemical reactions occurred during the manufacturing of VEACL. Cholesterol in the system raises the transition temperature of phospholipids and enhances the stability of VEACL. The EE remains above 80% despite a 20% increase in cholesterol levels. The release rate of VEA from cocoliposomes was slower with VEACL–20%Chol compared to VEACL–0%Chol. The cholesterol level leads to a decrease in particle size and an increase in the negative zeta potential of the cocoliposomes. Data show that cocoliposomes are effective carriers for VEA encapsulation.
Proposal of a novel index in assessing perinatal mortality in prenatal diagnosis of Sacrococcygeal Teratoma
Authors: Llancarí Pedro , Velarde-García Diego , Novoa Rommy H. , Ventura Walter
Published: January 2025

Objectives

To describe obstetric characteristics and perinatal outcomes in a serie of fetuses with Sacrococcygeal Teratoma (SCT) and propose a novel index to assess postnatal mortality based on the THC ratio and the addition of the presence of polyhydramnios.

Methods

A retrospective study in a referral teaching hospital between 2013 and 2023. A descriptive analysis and a receiver operating characteristic (ROC) curve were performed to the determine the optimal cutoff value of the THC plus polyhydramnios based on optimal sensitivity and specificity.

Results

Eleven out of 15 fetuses were included in our series during the study period. The median gestational age at prenatal diagnosis was 30.9 weeks and the median gestational age at birth was 35.8 weeks. Seven patients developed polyhydramnios. There was no intrauterine death. There were four deaths after birth (36.4 %). A cutoff value of THC plus polyhydramnios higher than 3.0 was associated with postnatal mortality with 100 % sensitivity and 86 % specificity. There was no significant difference comparing TFR with THC plus polyhydramnios.

Conclusions

We report a high postnatal mortality of 36 % among fetuses with diagnosis of Sacrococcygeal Teratoma. Additionally, we propose a potential useful index associated with postnatal mortality based on the THC and the addition of polyhydramnios with a sensitivity of 100 %.
Selenium compounds for cancer prevention and therapy – human clinical trial considerations
Authors: Lü Junxuan , Jiang Cheng , Hu Hongbo
Published: January 2025

Selenium (Se) is an essential trace mineral crucial for human health. Nearly a dozen human clinical trials with seleno-methionine (SeMet) and selenized-yeast (contains mostly SeMet) for the prevention of non-cutaneous solid organ cancers in North America and European countries conclusively refuted their utility. We have articulated two lessons from these trials: (1) the anti-oxidant hypothesis was tested in inappropriate Se-adequate populations, and (2) the selection of these Se forms was not supported by cell culture and animal efficacy data. Nevertheless, preclinical studies of proximal methylselenol precursors (“methyl Se”) have shown many desirable attributes, involving crucial molecules and pathways in cancer epithelial cells, vascular endothelial, immune and inflammatory cells in the tumor microenvironment, for potential use as chemopreventive and therapy agents. Methylseleninic acid and Se-methylselenocysteine are prototypical methyl-Se, yet not equal in their targets. Selenate, selenite and selenious acid had been recently studied in human clinical trials, providing novel safety data, but, missing critical genotoxicity assessments. Given the popularity of Se-enriched foods in China and a continued presence of nutritional Se deficiency in many localities, we discuss recommendations for clinical studies of Se forms for cancer therapy or chemoprevention in China and other countries with similar Se nutrition predicament.
“God Who Brought us Close and Then Repented”: Hester Panim and Revelation in Avraham Ben-Yitzhak’s Writings
Authors: Ben-Zur Yarden
Published: January 2025

In the following article, I propose a comprehensive exploration of Abraham Ben-Yitzhak’s poetry, centering on the dialectics of revelation and concealment, often referred to as “hester panim” in Hebrew. This concept, deeply rooted in traditional Jewish theology, signifies God’s concealment and exile from the human realm, where He hides His face and turns His back on His people. By examining Ben-Yitzhak’s poetry through the lens of “hester panim” we gain valuable insights into his work. This concept is not a mere theoretical framework; it is intricately woven into his early Hebrew poems and undergoes a significant evolution in his post-World War One German writings, dated around 1925.
A fiber-pigtailed quantum dot device generating indistinguishable photons at GHz clock-rates
Authors: Rickert Lucas , Żołnacz Kinga , Vajner Daniel A. , von Helversen Martin , Rodt Sven , Reitzenstein Stephan , Liu Hanqing , Li Shulun , Ni Haiqiao , Wyborski Paweł , Sęk Grzegorz , Musiał Anna , Niu Zhichuan , Heindel Tobias
Published: January 2025

Solid-state quantum light sources based on semiconductor quantum dots (QDs) are increasingly employed in photonic quantum information applications. Especially when moving towards real-world scenarios outside shielded lab environments, the efficient and robust coupling of nanophotonic devices to single-mode optical fibers offers substantial advantage by enabling “plug-and-play” operation. In this work we present a fiber-pigtailed cavity-enhanced source of flying qubits emitting single indistinguishable photons at clock-rates exceeding 1 GHz. This is achieved by employing a fully deterministic technique for fiber-pigtailing optimized QD-devices based on hybrid circular Bragg grating (hCBG) micro-cavities. The fabricated fiber-pigtailed hCBGs feature emission lifetimes of

<
80

${< } 80$

ps, corresponding to a Purcell factor of ∼9, a suppression of multi-photon emission events with g
(2)(0) < 1 %, a photon-indistinguishability

>
80

${ >} 80$

% and a measured single-photon coupling efficiency of 53 % in a high numerical aperture single-mode fiber, corresponding to 1.2 Megaclicks per second at the single-photon detectors under 80 MHz excitation clock-rates. Furthermore, we show that high multi-photon suppression and indistinguishability prevail for excitation clock-rates exceeding 1 GHz. Our results show that Purcell-enhanced fiber-pigtailed quantum light sources based on hCBG cavities are a prime candidate for applications of quantum information science.
Bismuthyl chloride/poly(m-toluidine) nanocomposite seeded on poly-1H pyrrole: Photocathode for green hydrogen generation
Authors: Alnuwaiser Maha Abdallah , Rabia Mohamed , Elsayed Asmaa M.
Published: January 2025

A novel photocathode has been developed for H2 gas generation from sewage water, utilizing a bismuthyl chloride–poly m-toluidine (BiOCl–PMT) nanocomposite supported on poly-1H pyrrole (P1HP). X-Ray photoelectron spectroscopy analysis confirms the formation of bismuth oxide intercalated within the polymer network through a chemical reaction, resulting in the creation of bismuth oxide chloride (BiOCl). This photocathode exhibits strong absorption in the UV region, extending into the visible spectrum, with a bandgap of 2.75 eV, enabling effective interaction with photons and efficient energy transfer to the photocatalyst nanomaterials. The material’s crystalline size is limited to 39 nm, and it features a highly porous polymer structure with a pore size of 20 nm, aggregating into larger structures approximately 300 nm thick. When employed as the working electrode in a three-electrode cell, the BiOCl/PMT/P1HP photocathode shows a measured photocurrent density (J
ph) of −0.046 mA/cm² under illumination, which drops to −0.032 mA/cm² when the light is turned off. The resulting photocurrent of 0.012 mA/cm² reflects the photocathode’s efficient photoelectrochemical behavior. The performance of the photocathode during sewage water splitting can be adjusted by varying the photon energies between 3.6 and 1.7 eV, using filters to control photon wavelengths. This variation is evident in the linear sweep voltammetry curves, with J
ph values ranging from −0.045 mA/cm² at 3.4 eV to about −0.042 mA/cm² at 1.7 eV under an applied bias voltage of −0.7 V. The photocathode’s high efficiency is further demonstrated by its ability to produce 15 µmol/h of H2 gas for a 10 cm² area. This promising performance, combined with cost-effectiveness, makes the BiOCl/PMT/P1HP photocathode an attractive option for green chemistry and industrial applications.
Development of Differential Sublaminar Feedforward Inhibitory Circuits in CA1 Hippocampus RequiresSatb2
Authors: Hanson Meretta A. , Bibi Noor , Safa Alireza , Nagarajan Devipriyanka , Marshall Alec H. , Johantges Aidan C. , Wester Jason C.
Published: January 2025

Pyramidal cells (PCs) in CA1 hippocampus can be classified by their radial position as deep or superficial and organize into subtype-specific circuits necessary for differential information processing. Specifically, superficial PCs receive fewer inhibitory synapses from parvalbumin (PV)-expressing interneurons than deep PCs, resulting in weaker feedforward inhibition of input from CA3 Schaffer collaterals. Using mice, we investigated mechanisms underlying CA1 PC differentiation and the development of this inhibitory circuit motif. We found that the transcriptional regulator SATB2, which is necessary for pyramidal cell differentiation in the neocortex, is selectively expressed in superficial PCs during early postnatal development. To investigate its role in CA1, we conditionally knocked outSatb2from pyramidal cells during embryonic development using both male and femaleEmx1IRES-Cre; Satb2flox/floxmice. Loss ofSatb2resulted in increased feedforward inhibition of CA3 Schaffer collateral input to superficial PCs, which matched that observed to deep PCs in control mice. Using paired whole-cell recordings between PCs and PV+ interneurons, we found this was due to an increase in the strength of unitary inhibitory synaptic connections from PV+ interneurons to mutant superficial PCs. Regulation of synapse strength was restricted to inhibitory synapses; excitatory synaptic connections from CA3 to CA1 PCs and CA1 PCs to PV+ interneurons were not affected by loss ofSatb2. Finally, we show that SATB2 expression in superficial PCs is necessary to suppress the formation of synapses from PV+ interneurons during synaptogenesis. Thus, early postnatal expression of SATB2 in superficial PCs is necessary for the development of biased feedforward inhibition in CA1.
Immersion into the Datascape
Authors: Lee Joo Yun
Published: January 2025

This essay examines an immersive audiovisual installation created by Paris-based Japanese composer and visual artist Ryoji Ikeda, who conjures micro/macro datascapes and their embodied experience, opening a new realm at the intersection of art and data, or data art. Ikeda interfaces his sound compositions with light, visuals, numerical data, and data visualization, bringing audible/inaudible and visible/invisible data into viewers’ fields of perception. Focusing on his exhibition the transfinite at the Park Avenue Armory in New York City in 2011, I examine Ikeda’s approach to temporal articulation in forging the viewer’s spatiotemporal immersion into the datascapes in his signature large-scale screen-centric installation work. Ikeda’s data composition—which evolved from his music composition—articulates a multi-substance of data from the infinitesimal to the infinite according to sonic media’s micro-temporality, formulating a new sensibility of our world enmeshed in unfathomable data at the threshold of the viewer’s perception. Given that Ikeda’s body of art is integral to his music, I trace the expansion of the arc of his work from music to visual art, discussing his composition of glitch microsound and his early sound-light installation spectra II (2002). Finally, I highlight that Ikeda’s screen-centric installations, stemming from his audiovisual performances and his association with the Japanese experimental collective Dumb Type’s intermedia production, have shaped a new kind of installation art with a distinct temporal dimension, immersing viewers into the constantly instantiated presence of datascapes rather than into the images on the screen as the direct representation of reality.
“Dwell on every detail and its possible meaning”
Authors: Pradhan Pritika
Published: January 2025

Pritika Pradhan, “‘Dwell on every detail and its possible meaning’: The Subjective Particulars of Middlemarch” (pp. 182–224)

This essay examines the engagement with details in George Eliot’s Middlemarch (1871–72) as a conduit for capturing emotional interiority. Details in Eliot’s novels—and in nineteenth-century realism in general—are identified with empirical observation and scientific objectivity. However, for Eliot, the representation of details signifies the advent of a modern subjectivity that closely attends to details and infuses them with emotion and significance. I trace Eliot’s enlivening of details to her engagement with nineteenth-century aesthetics, specifically Hegel’s Aesthetics (1835), which describes the profuse details of genre painting and poetry to be generated and animated by a reflective, inward modern subjectivity. Hegel’s thought converges with Eliot’s use of details to represent the growing inner complexity of her heroine, Dorothea Brooke, through her increasing engagement with details of the everyday world. Dorothea’s passionate, if misguided, perception and charging of details with emotion reflects her inner subjectivity, enacted by Eliot’s third-person narrator through metaphorical images that diffuse details into felt experience. In this scenario, Eliot’s diffusive metaphorical details render palpable an emotional interiority and complexity that eludes direct representation.
Novac Osmanskog Carstva iz sjeverne Dalmacije
Authors: Ilkić Mato , Filipčić Dejan
Published: January 2025

The paper discusses 23 Ottoman coins found in 16 sites in northern Dalmatia. Chronologically, they belong to the period from the second reign of Sultan Mehmed II, the Conqueror (1444–1446 and 1451–1481) all the way to the Egyptian coin bearing the name of Sultan Abdul Hamid II (1876–1909). These numismatic finds can be assigned to one of several different phases during which they came to northern Dalmatia: pre-Ottoman, Ottoman and post-Ottoman. The first phase includes the akçes of Sultan Mehmed II and Sultan Selim I (1512–1520). The second phase involves coins from the period of Ottoman rule, which lasted a little over a century and a half in the hinterland of northern Dalmatia. The third phase is represented by mangirs of Suleiman II (1687–1691), which were brought to northern Dalmatia shortly after the end of Ottoman rule, while the Morean War (1684–1699) was still in full flow. They are followed by numismatic finds from a much later period. Two specimens are associated with historical events related to northern Dalmatia and Egypt. One was minted for Sultan Selim III (1789–1807), and the second for Sultan Abdul Hamid II (1876–1909). The first can be related to the French intervention in Egypt in 1798, and the second with refugees fleeing from Dugi Otok to El Shatt in 1944–1945.
Vela Pećina kod Kali na Ugljanu – novo nalazište kasnoga gornjeg paleolitika na sjevernodalmatinskim otocima
Authors: Arbutina Leo , Bodružić Mario , Vujević Dario
Published: January 2025

U radu se iznose rezultati probnog iskopavanja Vele pećine kod Kali na otoku Ugljanu, s naglaskom na rezultate tehno-tipološke i petrografske analize litičkog skupa nalaza. Razmatra se značenje lokaliteta u mreži naseljavanja gornjopaleolitičkih lovaca sakupljača s obzirom na vremensko razdoblje potvrđeno radiokarbonskim datiranjem i geografski položaj lokaliteta na rubu danas potopljene Jadranske nizine.
Lasinjska kultura u Bosni i Hercegovini - u svijetlu nalaza bočice iz Visokog brda u Lupljanici kod Dervente
Authors: Balen Jacqueline
Published: January 2025

Na prostoru Bosne i Hercegovine ustanovljeno je vrlo malo lasinjskih lokaliteta te je taj prostor označen kao periferni prostor rasprostiranja ove kulture. Do sada je karakteristična lasinjska keramografija potvrđena na sedam lokaliteta u Bosni i Hercegovini: Zemunica u Radosavskoj kod Banjaluke, Visoko brdo u Lupljanici, Vis u Modranu kod Dervente, Donji Klakar kod Bosanskog Broda, Gornja Tuzla u Tuzli, Biograd u Pruscu kod Donjeg Vakufa i Stari grad Cazin. U radu se prikazuje nalaz bočice lasinjske kulture s lokaliteta Visoko brdo u Lupljanici kod Dervente, čime se potvrđuje važnost revizijskih istraživanja, kao i obrade nalaza sa starih istraživanja lasinjske kulture.
„Zajednica sa Skadarskog jezera” na prijelazu iz bakrenog u brončano doba
Authors: Guštin Mitja
Published: January 2025

Visoki kneževski humci s velikim grobnicama u obliku cista izrađenima od vapnenačkih ploča koji sadržavaju izuzetno bogate grobove, kao i oni sa jednostavnijim grobovima koji sadržavaju samo setove keramike, ukazuju na važnost zajednice i omogućavaju preciznije definiranje njezina kulturnog konteksta. Grobnice su geografski ograničene na malo područje između Kotorskog zaljeva, Skadarskog jezera i doline rijeke Zete u Crnoj Gori. Specifična grobna arhitektura, zgrčeni položaj pokojnika te istaknuti metalni i keramički predmeti ukazuju na osobitu kulturnu pojavu s poveznicama koje moguće sežu do Bliskog istoka. Humci s grobnicama u obliku kamenih cista, i oni pripadnika elite i oni s jednostavnijim keramičkim prilozima, predstavljaju istaknutu zajednicu koja je doživjela svoj procvat u razdoblju prijelaza iz mlađeg bakrenog u starije brončano doba, između 4. i 3. tisućljeća pr. Kr. U prošlosti su jedinstveni žigosani i urezani ukrasi na keramici doveli do pogrešnog povezivanja tih utjecajnih kneževa sa zajednicama u gornjojadranskom zaleđu i Ljubljanskom barju, kao i s vučedolskom kulturom, koja potječe iz istočne Slavonije i Srijema na desnoj obali Dunava. Uz dužno poštovanje prema trudu koji su naši znanstveni prethodnici uložili u praćenje procesâ davne prapovijesti, interpretacija „crnogorskog kneževskog horizonta”, koji predstavlja jednu od prvih prapovijesnih elita iz najviših društvenih slojeva, zahtijeva preciznost i odgovarajuću hijerarhiju. Nakon otkrića nekoliko humaka s grobnicama u obliku cista i kraljevskih insignija postalo je jasno koliko je veliko bilo područje na kojem je obitavala ova zajednica za koju, među ostalim i s obzirom na humke s područja susjedne Albanije, predlažemo ime „zajednica sa Skadarskog jezera” s prijelaza iz bakrenog u brončano doba.
Novac gradova Arpija i Dirahija s istraživanja na solinskoj Zaobilaznici
Authors: Marinović Ana
Published: January 2025

U tekstu se objavljuju dva primjerka novca iz helenističkog razdoblja otkrivena tijekom zaštitnih arheoloških istraživanja na Zaobilaznici 1986. i 1987. godine. Na solinskom području novac iz helenističkog razdoblja nije čest nalaz. Do sada su s područja Solina dokumentirani nalazi novca Herakleje, Dirahija, Apolonije, Sifnosa, zatim brončani novac Ise te novac Aleksandra Makedonskog.
The structure, process and outcomes of interprofessional care among knee osteoarthritis patients: a scoping review
Authors: Lee Jessica Hiu Toon , Kan Mandy Ming Pui , Wong Arkers Kwan Ching
Published: January 2025

Knee osteoarthritis (OA) is a common chronic condition that leads to joint pain and disability among older adults. An interprofessional collaborative approach has nowadays been widely advocated in knee OA management although little is known about the characteristics of care, roles and responsibilities of healthcare providers and how they collaborate as a team to optimise treatment outcomes.

The Donabedian structure–process–outcome framework was used in the review. Six databases were searched from February 2013 to March 2023.

A total of 26 articles that met our inclusion criteria were reported. All studies (n = 26) identified the physiotherapist as a critical member of the interprofessional team. Several studies (n = 5) have offered training to healthcare providers in the management of knee OA. The intervention components in most studies included disease-based education (n = 21) and exercise therapy (n = 16).

A comprehensive understanding of the existing interprofessional knee OA care in this review could potentially assist the government and healthcare organisations in developing interprofessional practice guidelines and designing intervention programmes that maximise their benefits.
Complications after knee derotational osteotomies in patients with anterior knee pain and/or patellofemoral instability: a systematic review with meta-analysis
Authors: Figueiredo Inês , Valente Cristina , Ribeiro Ricardo , Ferreira Bárbara , Gomes Eluana , Delgado Diego , Sánchez Mikel , Andrade Renato , Espregueira-Mendes João
Published: January 2025

Purpose

Investigate intra- and post-operative complications and revisions following distal femoral and/or high tibial derotational osteotomies to correct rotational malalignments of the lower limb in patients with anterior knee pain (AKP) and/or patellofemoral instability (PFI).

Methods

A literature search was conducted on PubMed, EMBASE and Web of Science (until 30 September 2023), including studies reporting complications, reinterventions and revisions following knee derotational osteotomies. Incidence rates were collected for each level of derotational osteotomy (distal femur, high tibia or double-level). A meta-analysis using the Freeman–Tukey double arcsine transformation was conducted to estimate the pooled proportions with their 95% confidence intervals (CIs).

Results

Twenty-one studies involving 564 osteotomies (n = 484) were included, with a mean follow-up of 45.6 ± 15.7 months. The overall complication proportion was 7.5% (95% CI: 3.9–11.8%). Postoperative residual AKP was seen in a pooled proportion of 7.6% (95% CI: 0.7–18.8%), and persistent PFI was not common (0.1%; 95% CI: 0.0–1.7%). Intraoperative complications occurred in a pooled proportion of 3.8% (95% CI: 2.4–6.0%), with peroneal nerve injury being the most common (1.3%) after derotational high tibial osteotomy. Reintervention was needed in a pooled proportion of 13.0% (95% CI: 2.9–27.2%), primarily for hardware removal (n = 158; 28.3%). There was a pooled proportion of knees requiring revision procedures of 12.3% (95% CI: 2.6–26.1%).

Conclusions

Distal femur and high tibial derotational osteotomies exhibit a considerable incidence of intra- and post-operative complications. Peroneal nerve injury, although infrequent, is a significant complication, underscoring the importance of implementing intraoperative preventive measures during derotational high tibial osteotomy.
Systems-level liquid biopsy in advanced prostate cancer
Authors: Lyman Jacqueline , Dehm Scott M
Published: January 2025

Treatment for castration-resistant prostate cancer (CRPC) primarily involves suppression of androgen receptor (AR) activity using androgen receptor signaling inhibitors (ARSIs). While ARSIs have extended patient survival, resistance inevitably develops. Mechanisms of resistance include genomic aberrations at the AR locus that reactivate AR signaling or lineage plasticity that drives emergence of AR-independent phenotypes. Given the diverse mechanisms of ARSI resistance in CRPC, there is a need for more effective monitoring strategies that detect signs of resistance to inform prognosis and guide use of alternative therapies. Liquid biopsy is a blood test that has emerged as a powerful, minimally invasive tool for investigating advanced cancer. In CRPC, liquid biopsy has been shown to reflect genomic and transcriptomic features in tumor tissue and has been utilized to detect an array of resistance signatures. Liquid biopsy is uninhibited by spatial restrictions and allows for longitudinal monitoring of disease progression. However, current clinical liquid biopsy tests provide limited actionable information. This review highlights recent advancements to the understanding of mechanisms driving treatment resistance in CRPC through research-grade liquid biopsy assays. We explore novel methods of disease characterization developed using liquid biopsy and emphasize the clinical potential of a multi-omics molecular profiling approach to comprehensively detect emerging therapeutic resistance. Routine assessment of therapy resistance using a liquid biopsy assay has the potential to enhance prognostication and improve outcomes of men with CRPC.
Perspectives of Persons with Memory Changes and Care Partners for Reducing Barriers to Community Wellness Programs
Authors: Wei Cindy , Trinca Vanessa , Middleton Laura , Keller Heather
Published: January 2025

Exercise and healthy diet can improve the well-being of community-dwelling persons with memory changes (PWMC) (including dementia) and care partners (CPs). Existing research demonstrates that PWMC and CPs benefit from nutrition and exercise for frailty and sarcopenia prevention. Yet, needs and preferences for wellness programs are still unknown. The objective of this eight-month online survey study was to explore PWMC (n=24) and CPs’ (n=46) perspectives on nutrition/exercise barriers, and preferences for program content and format to inform a community wellness program. PWMC self-reported, while CPs reported for themselves and their cared-for person with dementia (CPWD). Descriptive analyses revealed that 78% of PWMC, 64% of CPs, and 39% CPWDs were interested in a wellness program that combined nutrition and exercise. Content preferences were diverse (e.g., 45% of CPs were interested in yoga/Pilates, but only five percent of CPWD were interested). Over half of participants preferred online delivery for nutrition information (55% PWMC, 54% CP). Group fitness was popular for exercise among all groups. In addition, participants prioritized attending as dyads twice or more per week, closeness to home, reasonable cost, knowledgeable instructors, fun social environment, and beginner-friendliness. To conclude, flexibility in program content and format will meet diverse needs and preferences.
Review of DSM-5 Diagnostic Criteria for Anorexia Nervosa and Recommendations to Improve Inclusivity
Authors: Sabrina Lutchmeah
Published: January 2025

This article reviews issues with the diagnostic criteria for anorexia nervosa, which is a controversial topic. It discusses how the criteria can be vague and exclude certain populations who can be affected by this eating disorder. After this discussion, some suggestions to improve the diagnostic criteria are made in order to ensure more inclusivity in the diagnosis of anorexia nervosa. This article is meant to provide a new perspective on how the current diagnostic criteria has some limitations which may imply that all the affected individuals who need help are not receiving it. The current criteria is directed towards a very specific subset of the population who lives with anorexia nervosa, and it does not include other subsets who present with different symptoms.
A Gendered Perspective of the Lack of Justice for the Asubpeeschoseewagoon Anishinabek Women of Grassy Narrows
Authors: Armstrong Amanda
Published: January 2025

From 1962 to 1970, the Reed Paper Mill dumped over 9000 kilograms of mercury into the English-Wabigoon River system in Northern Ontario. The Grassy Narrows community, an Anishinabek First Nation, depend on this water system for sustenance and their livelihoods. Their reliance specifically on fish as a primary source of food and income increases their community’s vulnerability to mercury poisoning, which has resulted in lasting impacts on the physical and mental health of their community. Grassy Narrows women are disproportionately impacted by mercury poisoning due to their gendered responsibility to protect water, care work, and child-bearing. This paper examines the failure of the Government of Ontario to uphold the foundational elements of environmental justice for Grassy Narrows women, including distributive fairness, procedural fairness, and corrective action. Recommendations for the Government of Ontario include listening to the needs of Grassy Narrows First Nations and including them in decision-making processes to help ease the generational pain caused by perpetual environmental racism.
Formación inicial en historia de la ciencia del profesorado STEM de la Comunidad de Madrid: Relevancia, diagnóstico y propuestas desde la investigación educativa
Authors: Moreno-Martínez Luis
Published: January 2025

El presente trabajo analiza la presencia de la historia de la ciencia en la formación del profesorado STEM de Enseñanza Secundaria de la Comunidad de Madrid atendiendo los planes de estudios del Máster Universitario en Formación del Profesorado, los temarios de acceso a la función pública docente y el currículo de ESO y Bachillerato. El estudio realizado ha mostrado que la relevancia otorgada por la investigación educativa a la historia de la ciencia encuentra respaldo en el marco normativo que rige la acción del profesorado STEM de Enseñanza Secundaria, si bien son identificables reseñables diferencias entre especialidades docentes y propuestas de mejora comunes, como la necesidad de reforzar el enfoque competencial en la formación docente en historia de la ciencia.