bluuebunny/crossref_metadata_2025 huggingface dataset:
What Happens Before the Last Mile? Exploring a Package’s Journey
Authors: Tejada Carla , Conway Alison
Published: October 2022

Urban freight studies of e-commerce activities and impacts tend to focus on last-mile movements of goods. Little information is available to quantify e-commerce activity for residential deliveries of parcels upstream of the last mile. In this exploratory study, we investigate the usefulness of a novel type of data—individual package tracking records—to measure end-to-end e-commerce activity. Using a small case study, we measure distances, times, and speeds of service to characterize components of e-commerce supply chains and to understand related impacts on transportation networks. Our results detail the strengths, weaknesses, and challenges expected in using this type of data, as well as provide insights for future data collection efforts. Overall, our results indicate that package tracking records do provide information that is potentially useful to inform transportation planning, but that further efforts are needed to establish appropriate technical and institutional frameworks to support large-scale analysis.
Feasibility Study of a Compatible Design Method for Asphalt Concrete-Based Track Substructure Considering Viscoelastic Properties
Authors: Hu Ting , Fang Mingjing , Fang Kun , Mo Liantong , Xiao Yue
Published: October 2022

An evaluation is needed as to whether the constant thickness for the formation layer of 0.4 m and the bottom layer of 2.3 m in China’s current subgrade design is appropriate for the asphalt trackbed given its viscoelastic properties. This paper presents numerical research on the compatible design of roadbed thickness for asphalt concrete-based track (AC-based track) with SBS-25, using finite element modeling (FEM). Accordingly, a compatible design method for the substructure of an AC-based track was proposed following field and data investigation, material and numerical testing, as well as optimization and field testing with soundness verification. Compared with the traditional design, the formation layer needs to be strengthened, and the bottom layer thickness can be appropriately reduced or replaced with building solid waste. The dynamic stress attenuation rate and dynamic-static stress ratio are taken as the design standards of formation and bottom layers, respectively. The optimal design scheme at 20°C is determined when the asphalt track is 300 mm thick, the formation layer of 0.50 m and the bottom layer of 1.87 m are matched. However, at 40°C, the dynamic deformation control fails to pass the verification. Therefore, it is necessary to adjust the thickness of the asphalt trackbed or change the types of asphalt binder to carry out the numerical test again if applied in a high-temperature region. The findings contribute to the AC-based track substructure design; however, the proposed design method still needs further improvement and verification from the field or full-scale indoor tests.
Assessing Premature Cracks in Urban Concrete Pavements
Authors: DeSantis John W. , Roesler Jeffery , Cantu Roberto Montemayor
Published: October 2022

There are many urban jointed plain concrete pavements (JPCPs) constructed annually in the U.S. by counties, cities, and municipalities, which typically use state department of transportation standards but are not part of a systematic check to determine if design, construction, and performance are meeting expectations. A field evaluation survey with nondestructive testing was initiated on urban JPCPs throughout Illinois to assess performance and identify any deficiencies in design and construction. A total of 67 JPCPs were selected based on their design features and age. A significant number of sections (57%) were selected because they exhibited some level of premature cracking. Based on the field investigation, multiple mechanisms were proposed to explain the premature cracks. Many transverse and longitudinal cracks observed had excessive slab lengths or widths that were inconsistent with best slab geometry practices. There was no link established between observed cracking and the slab-base frictional restraint or the concrete mixture. For some sections, ultrasonic tests over the contraction joints determined certain joints had not activated and likely contributed to transverse cracks in adjacent slabs. Lack of dowel bar lubrication at the transverse contraction joints was also a plausible mechanism that restrained joint movements and produced excessive tensile stresses in the slab, which led to premature transverse cracks. The mechanisms leading to almost all observed premature cracks for these urban JPCPs were attributed to not adhering to existing state standards (slab geometry limits) and specifications (saw-cut timing/depth and dowel lubrication) during the pavement design and construction phases.
Breast Fat Grafting: 10-Year Learned Clinical Experience
Authors: Troell Robert J.
Published: October 2022

Our being strives for staying youthful and being beautiful. Beauty for woman encompasses the entire body from the face, down to the breasts, the torso, buttocks, and extremities. Breast enhancement using implants is consistently ranked as one of the most common aesthetic surgical procedure undertaken by woman. However, as alloplastic implants suffer numerous potential complications and revision surgery, some practitioners and patients seek alternative treatment. Autologous fat grafting has gained popularity due to its safety and scientific advances yielding increased adipocyte survival. The low complication rate and valuable cosmetic outcomes will continue to have patients request natural breast augmentation. The authors’ more than 12 years of clinical experience with autologous fat transfer to the breast is presented. Advances in fat processing, enrichment, and administration are highlighted. The addition of stem cells, stromal vascular fraction, and platelet-rich plasma (PRP) is elucidated during the clinical experience. Laboratory evaluation of fat survival comparing ultrasound- and suction-assisted fat harvesting is presented. A comparison of 2 distinct fat processing methods is done using both clinical evaluation by the patients and surgeon, and the use of diagnostic ultrasound to assess fat thickness before and after surgical placement. The filtration device (Puregraft, Solana Beach, California) was compared with the Lipokit or filtration, centrifugation device (Medi-Khan USA, Inc., Los Angeles, California). Breast fat grafting was used for sole breast augmentation, after silicone breast implant surgery, in conjunction with mammopexy surgery, and reconstruction after breast cancer surgery or explantation. The authors’ observation with breast fat grafting volumetric outcomes has seen an increase from about 30% to almost 80%. This increased volume is related to the placement of a purer fat graft with less wetting solution fluid with less blood and oil. Minimizing ultrasound energy during the harvesting, lower suction levels, short fat storage times of 1 to 2 hours prior to administration, purification of fat without washing away growth factors, and the enrichment of fat with fat-derived autologous stem cells and blood-derived PRP have been observed techniques to optimize fat survival. Breast fat grafting using much of the current knowledge of harvesting, processing, enrichment, and administration has yielded superior adipocyte survival. This increased survival has provided more consistent breast enhancement results.
Dating App Facilitated Sexual Assault: A Retrospective Review of Sexual Assault Medical Forensic Examination Charts
Authors: Valentine Julie L. , Miles Leslie W. , Mella Hamblin Kristen , Worthen Gibbons Aubrey
Published: October 2022

Dating app facilitated sexual assault (DAppSA) is a concerning phenomenon with minimal published research. This retrospective study explored if DAppSAs were different than other sexual assaults (SAs) committed by acquaintances through a review of 3,413 sexual assault medical forensic examination (SAMFE) charts from 2017 to 2020 in a Mountain West state in the United States. Routine Activities Theory and Confluence Model of sexual aggression provided the theoretical framework for the study. Inclusion criteria for DAppSA cases included (1) victim was 14 years of age or older; (2) victim indicated meeting the perpetrator on a dating app; (3) SA occurred at initial in-person meeting; and (4) victim had a SAMFE with SA kit evidence collection. DAppSAs ( n = 274) represented 8.02% of overall cases and 13.92% of acquaintance SAs ( n = 1,968). DAppSA victims had unique characteristics including a higher percentage of male victims (7.5%), college students (22.2%), and victims with self-reported mental illness (MI) (59.6%). Victims were less likely to fight back during the assault with lower percentages of kicking (5.8%) and hitting (9%). DAppSA victims and perpetrators were less likely to use drugs or alcohol before or during the assault. DAppSAs were found to be more violent SAs with increased strangulation (32.4%); assaultive/penetrative acts; and victim injuries, especially anogenital and breast injuries. Unique and troubling differences were found in DAppSA cases than other SAs committed by acquaintances. Due to the increased violent nature of DAppSAs, the researchers propose that sexual predators use dating apps as hunting grounds for vulnerable victims. Recommendations to address dating app safety concerns, influence dating app usage policies, and improve care to survivors are discussed through systems-based and trauma-informed approaches.
Reproductive Coercion in Heterosexual and Sexual Minority Emerging Adults: Prevalence and Behavioral Health Impact
Authors: Swan Laura E. T. , Goffnett Jacob , Pless Jennie , Andrews Tyler
Published: October 2022

Reproductive coercion (RC) is a type of intimate partner violence (IPV) characterized by partner interference with contraception or reproductive decision-making. Despite sexual minority people’s vulnerability to other forms of IPV, limited research has examined reproductive coercion in this population. Research on behavioral health impacts of reproductive coercion is also lacking, especially for sexual minorities. This study addressed these gaps by examining the occurrence and behavioral health impact of reproductive coercion among emerging adults, including both heterosexual and sexual minority people. In 2020, survey data were collected with emerging adults (aged 18–24 years) at a university in the southeastern United States (N = 387). We conducted bivariate analyses to explore associates of reproductive coercion and logistic regression to identify risk factors. We then conducted linear regression to investigate relationships between reproductive coercion and behavioral health outcomes, in the full sample and in separate models based on sexual attraction. One in 15 sampled students (6.3%) had experienced reproductive coercion. Sexual attraction was a significant risk factor for reproductive coercion, with increased rates among plurisexual (i.e., attracted to people of multiple genders) compared to monosexual students, in both bivariate (χ2(2) = 7.57, p = .023) and regression analyses ( B = 1.25, p = .012). Reproductive coercion was associated with worse behavioral health outcomes in bivariate and regression analyses (anxiety: B = 3.77, p = .001; depression: B = 3.26, p = .010; alcohol use: B = 2.32, p < .001). In separate linear regression models based on sexual attraction, RC was significantly associated with behavioral health indicators for participants who were attracted only to men and those attracted to people of multiple genders but not for participants who were attracted only to women. Findings indicated increased RC risk for plurisexual students compared to monosexuals and showed significant associations between RC and behavioral health outcomes, with differential effects based on sexual attraction. These novel findings support the need for continued research on RC, inclusive of nuanced conceptualizations of sexuality.
The practical relevance of strategy education: Evidence from the lived experiences of business school alumni
Authors: Ngwenya Amkela , Davis Annemarie , Ncube Douglas
Published: October 2022

This paper presents the findings from a study on the dynamic and nuanced relationship between strategy theory and strategy practice in a South African context. Grounded in a strategy-as-practice perspective and based on an abductive analysis of sixteen semi-structured interviews, the empirical findings deepen our conceptual understanding of how the relationship between strategy theory and strategy practice is constituted. The findings further reveal how practice environments influence the effective use of academic knowledge and skills by graduates in the workplace. Primarily, strategy theory is foundational to effective strategy practice. We theorise that strategy practitioners construct the relevance of strategy theory through adaptation and bricolage to suit complex and eclectic practice contexts. The study findings confirm that strategy theory plays a critical role in shaping and guiding strategy practitioners’ praxis. As the ontic sites of knowledge and skills application, practice contexts are important for testing and validating academic knowledge and skills. In this relationship, strategy practitioners are the primary actors who transpose knowledge and skills from academe to business. What they become after completing a qualification is critical.
Friction and wear characteristics of synthetic diamond and graphene-filled polyether ether ketone composites
Authors: Kumar Vishal , Kaliyamoorthy Rajkumar
Published: October 2022

Modifying tribo films using filler particles is a significant area of research in developing polymer-based tribo components to minimize material loss during the sliding process. This study focused on altering the wear characteristics of a polyetheretherketone (PEEK)/graphene high-performance polymer composite to strengthen the tribo film by adding synthetic diamond particles. The hot-pressed PEEK composite reinforced by graphene and diamond particles increased the hardness and thermal stability of the composite. Compared with pure PEEK, composites containing 1% graphene and 1% diamond particles showed an increment of 25% and 23% in hardness and thermal stability, respectively. Fourier-transform infrared spectroscopy and X-ray diffraction analysis verified the compatibility and intactness of the fillers in the PEEK matrix. The tribo properties of PEEK composites were characterized by a pin-on-disc tribometer on a counter steel surface. A PEEK composite containing 0.75 wt% graphene and 0.5 wt% diamond particles exhibited the lowest friction of 0.17 at a pressure of 1.5 MPa. The specific wear rate was low (1.78 × 10−6 mm3/Nm) for the composite containing 1 wt% graphene and 1 wt% diamond particles at a pressure of 1.5 MPa. Varying synthetic diamond and graphene filler concentrations in the PEEK matrix change the wear process by modifying the tribo film characteristics, revealing the lowest friction and wear rate. X-ray photoelectron and Raman spectroscopy show that the polymer film was transferred to the steel countersurface, and the tribo-chemical products of the tribo film contribute to a stable tribo film. The ferric oxide film and the tribo film improve the composite’s self-lubricating properties and load-bearing ability. Hence, the composite containing 0.75% of graphene and 0.5% of a synthetic diamond can be employed in the sliding bearing application of continuous conveyors used in mass production systems.
Achyranthoside D (AD) improve intervertebral disc degeneration through affect the autophagy and the activation of PI3K/Akt/mTOR pathway
Authors: Zhang Chao , Li Zhaoyong , Li Linghui , Li Shuofu , Yang Lei , Chen Long , Zhang Xiao , Yang Shaofeng , Guo Yantao
Published: October 2022

Purpose

This study aims to explore the potential mechanism of Achyranthoside D (AD) in improving intervertebral disc (IVD) degeneration (IDD).

Methods

The IDD model of SD rats and nucleus pulposus cells (NPCs) was established by lumbar cone annulus puncture and tert-butyl peroxide, respectively. Cell proliferation was detected by CCK8 assay. Apoptosis was detected by flow cytometry and TUNEL staining. IVD tissue injury was observed by HE staining. Alcian blue staining observed the glycoprotein secretion in IVD. Monodansylcadaverin (MDC) staining was used to detect the formation of autophagosomes. The LC3 expression was tested by immunofluorescence. The type II collagen, aggrecan and MMP3 expression were detected by ELISA. RT-qPCR was used to detect the Casp 3, Bax, Bcl2, Acan, Col2a1 and Mmp3 expression. The LC3, P62, type II collagen, aggrecan, Beclin1, Akt, MMP3, p-mTOR, PI3K, mTOR, p-PI3K and p-Akt expression were analyzed by western blot.

Results

The IVD tissue damage and apoptosis occurred in the Model group, and the glycoprotein secretion decreased. Compared with Model group, AD-H group alleviated the injury of IVD tissue, inhibited the apoptosis of cells, and increased the secretion of glycoprotein. 40 μg/mL AD restored the proliferation activity of NPCs. Compared to the Normal group, the NPCs apoptosis increased, the Collagen II, aggrecan and Bcl2 expressions were significantly decreased, the MMP3, Bax and Casp 3 expression were significantly increased, and the LC-3 II/I expression in IVD tissues were increased significantly in Model group, all of which was reversed in AD group. AD promoted the p-Akt, p-PI3K, p-mTOR, LC-3 II/I and Beclin1 expression, inhibited the P62 expression to alleviate the damage of nucleus pulporeus cells and the degeneration of IVD.

Conclusion

AD improved IDD by affecting the PI3K/Akt/mTOR pathway and autophagy.
Evaluation of barcoded magnetic bead–based immunoassays for the simultaneous detection of feline leukemia virus antigen and antibody against feline immunodeficiency virus
Authors: Esty Kathy , Elmer Haylea , Nassar Salam , Ruggiero Anthony , Singh Seema , Beall Melissa , Buch Jesse
Published: October 2022

Testing platforms that leverage automation, require minimal sample volume, and enable various tests to be performed simultaneously on a single sample have the potential to improve workflow and efficiency in veterinary diagnostic laboratories. We evaluated a barcoded magnetic bead (BMB) technology using established immunoassays for detection of feline leukemia virus (FeLV) p27 antigen and antibody against feline immunodeficiency virus (FIV). Analytical sensitivity, limit of blank, and limit of detection were used to establish a functional sensitivity of 1.00 ng/mL of inactivated FeLV antigen and 35.7 ng/mL of anti-FIV monoclonal antibody. Common interferents, such as hemoglobin, lipid, and bilirubin, were not found to interfere with the performance of the assay. Intra- and inter-assay CVs were <13% for both assays using manufactured samples. Using a set of 116 feline samples, the diagnostic accuracy of our multiplex assay was 100% compared to reference assays. Performance in a convenience set of 1,000 feline samples submitted to a commercial diagnostic laboratory revealed a proportion of positive results of 1.3% for FeLV and 3.7% for FIV. BMB technology should enable rapid screening of samples for various markers in a single immunoassay well.
T-cell lymphoma in a Himalayan black bear in China
Authors: Zhao Li , Liu Yonghong , Zhi Yu , Huang Jintian , Wang Wenlong , Gao Wa , Ding Yulin , Liu Shuying , Wang Jinling
Published: October 2022

A 12-y-old Himalayan black bear suddenly developed depression, anorexia, cough, and dyspnea and died at the Ordos Zoo, China. At autopsy, the mesenteric and cranial mediastinal lymph nodes (LNs) were enlarged; the largest cranial mediastinal LN was ~13 cm in diameter. Scattered-to-diffuse, rounded-or-oval, gray, firm 1–6-mm nodules were observed on the surfaces of the spleen, liver, lungs, and small intestine. Histologically, the enlarged cranial mediastinal and mesenteric LNs, spleen, small intestine, lungs, and liver contained dense populations of neoplastic lymphoid cells (NLCs). The NLCs were round-or-oval with small amounts of mildly eosinophilic cytoplasm and round-or-oval hyperchromatic nuclei with indistinct nucleoli; the mitotic count was 55 in 2.37 mm2. Immunohistochemically, cell membranes and the cytoplasm of NLCs were CD3+, CD79a−, CD20−, CD15−, CD30−, and CD45RA−; hence, the NLCs were derived from T lymphocytes. To our knowledge, T-cell lymphoma has not been reported previously in a Himalayan black bear.
Phonics 101: Preparing Teachers to Provide Effective Intervention in Word Reading Skills
Authors: Lane Holly B. , Contesse Valentina A. , Gallingane Caitlin
Published: October 2022

Students with learning disabilities in word-level reading typically require explicit, systematic, and intensive phonics intervention. Teachers’ capacity to provide effective intervention depends largely on their depth of understanding of language and their proficiency with evidence-based instructional methods. This article outlines the key knowledge and skills needed to implement effective phonics intervention and provides suggestions for methods that teacher educators can use to develop candidates’ knowledge and skills.
Aligning Special Education Teacher Training With Reading Science: Challenges and Recommendations
Authors: Solari Emily J. , Hayes Latisha , Demchak Alisha , Wilburn Katie E.
Published: October 2022

This article discusses developing special education teacher candidates who have a solid knowledge of scientifically aligned reading practices. Challenges in preservice teacher education are presented, including alignment of course work and clinical experiences to the robust evidence base in reading science. Key questions and resources are presented to guide teacher education in developing evidence-based reading methods courses and clinical experiences.
Baricitinib Versus Tocilizumab for the Treatment of Moderate to Severe COVID-19
Authors: Reid Nancy Kierstin , Joyner Kayla Rena , Lewis-Wolfson Temeka Dawn
Published: October 2022

Background:

To date, minimal data directly compare tocilizumab with baricitinib for treatment in moderate to severe COVID-19.

Objective:

To compare the rates of in-hospital mortality with progression to mechanical ventilation in patients with COVID-19 who received either tocilizumab or baricitinib.

Methods:

The authors conducted a single-centered, institutional review board–approved, retrospective cohort study. Patients who were 18 years or older who were hospitalized with COVID-19 and who received tocilizumab or baricitinib were included. The primary end point is a composite outcome of progression to mechanical ventilation or in-hospital mortality. Secondary end points include components of the composite outcome and progression to higher level of care, duration of mechanical ventilation, and hospital and intensive care length of stay. Safety end points include the incidence of infections and thrombosis.

Results:

A total of 176 patients were included, of whom 61 (34.7%) received tocilizumab and 115 (65.3%) received baricitinib. In the primary outcome, there was no difference between the groups (52.5% tocilizumab vs 44.3% baricitinib, P = 0.305). For safety outcomes, there was a higher instance of thrombosis (11.5% tocilizumab vs 3.5% baricitinib, P = 0.042) and rates of antibiotic use after initiation of therapy (55.7% tocilizumab vs 38.3% baricitinib, P = 0.026) in the tocilizumab group.

Conclusion and Relevance:

There was no significant difference in the composite outcome in patients who received tocilizumab or baricitinib for the treatment of COVID-19. However, there was an increase in rates of thrombosis in those receiving tocilizumab compared with baricitinib. These results need to be confirmed in larger prospective, randomized trials.
Effect of Antidiabetic Therapy on Clinical Outcomes of COVID-19 Patients With Type 2 Diabetes: A Systematic Review and Meta-Analysis
Authors: Zhan Kegang , Weng Liuqi , Qi Li , Wang Luhan , Lin Hao , Fang Xiaoyu , Jia Hong , Ma Xiangyu
Published: October 2022

Background:

No study has yet systematically evaluated the effect of antidiabetic therapy on clinical outcomes of COVID-19 patients with type 2 diabetes (T2D).

Objective:

We aimed to evaluate the effect of different antidiabetic therapy on clinical outcomes of COVID-19 patients with T2D.

Methods:

We comprehensively retrieved the published research which examined the effect of antidiabetic therapy on clinical outcomes of COVID-19 patients with T2D. The odds ratio (OR) and its 95% confidence interval (95% CI) for clinical outcomes were calculated using the random-effects model, and meta-regression was adopted to evaluate the potential sources of heterogeneity between studies.

Results:

A total of 54 studies were included in this study. We found that the use of metformin (OR = 0.66, 95% CI: 0.58-0.75), SGLT-2i (OR = 0.80, 95% CI: 0.73-0.88), and GLP-1ra (OR = 0.83, 95% CI: 0.70-0.98) were significantly associated with lower mortality risk in COVID-19 patients with T2D, while insulin use might unexpectedly increase the ICU admission rate (OR = 2.32, 95% CI: 1.34-4.01) and risk of death (OR = 1.52, 95% CI: 1.32-1.75). No statistically significant associations were identified for DPP-4i, SUs, AGIs, and TZDs.

Conclusion and Relevance:

We demonstrated that the usage of metformin, SGLT-2i, and GLP-1ra could significantly decrease mortality in COVID-19 patients with T2D. The heterogeneity across the studies, baseline characteristics of the included patients, shortage of dosage and the duration of antidiabetic drugs and autonomy of drug selection might limit the objectivity and accuracy of results. Further adequately powered and high-quality randomized controlled trials are warranted for conclusive findings.
Factors Associated with Child Removal Among American Indian and Alaska Native People in an Alcohol Intervention Study
Authors: Lyons Abram J. , Hirchak Katherine A. , Kordas Gordon , Herron Jalene L. , Jansen Kelley , Alcover Karl C. , Bergerson Dustin , Avey Jaedon P. , Shaw Jennifer , Roll John , Buchwald Dedra , McDonell Michael G. ,   the HONOR Study Team
Published: October 2022

This study was a secondary data analysis of factors associated with alcohol-related child removal among American Indian/Alaska Native (AI/AN) adults enrolled in a clinical trial of an alcohol intervention. Among 326 parent participants, 40% reported ever having a child removed from their care in part because of the parent’s alcohol use, defined here as alcohol-related child removal. Seventy-five percent of parents reported at least one separation during their own childhood (M = 1.3, SD = 1.0). In a multivariable analysis, alcohol-related child removal was associated with parental boarding school attendance. No relationship was found between alcohol-related child removal and alcohol intervention outcomes. Results may provide evidence of multigenerational child removal impacts of boarding schools on AI/AN adults receiving an alcohol use disorder intervention. Assessment of parental history of child removal by practitioners, strategies to prevent alcohol-related separation and to support reunification should be integrated into addiction treatment in AI/AN communities.
Co-Culturing Rat Dorsal Root Ganglion Neurons With Rat Schwann Cells Protects Them Against the Cytotoxic Effects of Silver and Gold Nanoparticles
Authors: Gao Wenjuan , Lai James C. K. , Leung Solomon W.
Published: October 2022

Previous studies using monotypic nerve cell cultures have shown that nanoparticles induced neurotoxic effects on nerve cells. Interactions between neurons and Schwann cells may protect against the neurotoxicity of nanoparticles. In this study, we developed a co-culture model consisting of immortalized rat dorsal root ganglion (DRG) neurons and rat Schwann cells and employed it to investigate our hypothesis that co-culturing DRG neurons with Schwann cells imparts protection on them against neurotoxicity induced by silver or gold nanoparticles. Our results indicated that neurons survived better in co-cultures when they were exposed to these nanoparticles at the higher concentrations compared to when they were exposed to these nanoparticles at the same concentrations in monotypic cultures. Synapsin I expression was increased in DRG neurons when they were co-cultured with Schwann cells and treated with or without nanoparticles. Glial fibrillary acidic protein (GFAP) expression was increased in Schwann cells when they were co-cultured with DRG neurons and treated with nanoparticles. Furthermore, we found co-culturing with Schwann cells stimulated neurofilament polymerization in DRG neurons and produced the morphological differentiation. Silver nanoparticles induced morphological disorganization in monotypic cultures. However, there were more cells displaying normal morphology in co-cultures than in monotypic cultures. All of these results suggested that co-culturing DRG neurons with Schwann cells imparted some protection on them against neurotoxicity induced by silver or gold nanoparticles, and altering the expression of neurofilament-L, synapsin I, and GFAP could account for the phenomenon of protection in co-cultures.
Crossing the Threshold: Organizational and Community Correlates of Female and Minority Representation Among U.S. Law Enforcement Agencies
Authors: Frazier Joanna D. , Matusiak Matthew C.
Published: October 2022

The current research explores relationships between female and minority officer representation and elements of organizational structure, practices, and context (internal and external). These relationships are viewed through the lenses of representative bureaucracy and structural contingency theory. Employing LEMAS (2016) survey and ACS (2011–2015) data, a series of OLS regression models explored these relationships. Findings suggest diversity breeds diversity in law enforcement agencies. Organizational structure continues to influence female and minority officers throughout their careers. Structural elements of both complexity and control were related to officer representation at all three career points, as were organizational practices. Finally, relationships related to internal context demonstrated greater consistency than external, although external context was related to overall representation. Relationships between structure, practices, and context varied for females and minorities, suggesting a greater need for unique recruitment and retention strategies for these officers.
Perceptions and Knowledge Around Substance Use Disorders and the Role of Occupational Therapy: A Survey of Clinicians
Authors: Mattila Amy M , Santacecilia Gabriella , LaCroix Rebecca
Published: October 2022

Background:

Today’s healthcare system requires practitioners to acquire a level of confidence, knowledge, and personal desire that enables them to treat a growing clientele with substance use disorders (SUDs). Although SUDs impact millions of Americans, there are many barriers to receiving treatment. It is important to understand how occupational therapy (OT) practitioners’ perceptions of working with clients who experience SUDs relate to the knowledge and skills required to identify and provide treatment.

Method:

Two surveys, the Medical Regard Scale and modified Drug Problems Perceptions Scale, were utilized to analyze participants attitudes, perceptions, and knowledge around working with individuals with SUDs. Data was collected from 116 practitioners with a variety of experience, practice settings, and backgrounds in understanding SUDs.

Results:

The majority of respondents reported no formal training in treating clients with SUDs (72.4%). In terms of attitudes around working with this population, a fraction reported a preference not to work with patients experiencing SUDs (16.0%) or finding them “irritating” to work with (12.9%), while 62.0% reported they felt especially compassionate toward this population. The majority of respondents felt that insurance plans should cover patients like this to the same degree that they cover patients with other conditions; however, only 48.3% had a clear idea of their responsibilities in helping individuals with SUDs. In regard to knowledge around working with SUDs, just over half of respondents reported a true working knowledge of SUDs and SUDs related problems (53.4%).

Conclusion:

Occupational therapy practitioners would benefit from additional training, resources, and support related to provision of services to individuals with SUD. In addition, training to continue to reduce stigma within the profession can potentially increase access to care.
Calcium Potentiated Carbapenem Effectiveness Against Resistant Enterobacter Species
Authors: Isawumi Abiola , Abban Molly Kukua , Ayerakwa Eunice Ampadubea , Mosi Lydia
Published: October 2022

Background:

Antimicrobial resistance (AMR) remains a global health challenge, as bacteria display increasing resistance to last-resort antibiotics such as carbapenems. Enterobacter cloacae are evolving and developing high level of resistance to carbapenems. With increasing AMR, availability of antibiotics for treatment dwindles, hence a need to complement antibiotics to enhance activity or reduce the level of resistance. This study explored the use of calcium ions in attenuating bacterial resistance to carbapenems.

Method:

E. cloacae strains isolated from hospital fomites and air were subjected to antimicrobial susceptibility testing with carbapenem antibiotics (imipenem, meropenem, doripenem and ertapenem) using the disc diffusion ( E. coli ATCC 25922 as control). Growth profile, Ca-Adjusted assay and time-kill curve of the strains was determined in the presence and absence of carbapenem antibiotics following a calcium stress assay.

Results:

Growth profile showed that all the E. cloacae strains grew markedly well at 37°C relative to ATCC 25922 and all strains displayed 80% to 100% level of resistance to tested antibiotics. The growth rate of the strains in the presence of the antibiotics was comparable to the growth rate in the absence of carbapenems. Conditional growth stress with calcium ions showed a 50% reduction in the level of resistance with doripenem displaying the lowest level of reduction and ertapenem, the highest.

Discussion:

The study showed that E. cloacae strains displayed high levels of resistance to carbapenems, increasing the possibility of treatment failure. Challenging strains with calcium prior to antibiotic treatment led to a significant reduction in level of resistance, indicating that calcium ions could affect bacterial strains during antibiotic activity leading to reduction in level of resistance.

Conclusion:

Calcium supplement could potentiate carbapenem effectiveness and reduce bacterial AMR.
Occurrence of New Delhi Metallo-Beta-Lactamase 1 Producing Enterococcus Species in Oghara Water Nexus: An Emerging Environmental Implications of Resistance Dynamics
Authors: Bright Esegbuyota Igere , Hope Onohuean , Oyama Gxalo
Published: October 2022

Various members of the enteric bacteria in recent times are evolving diverse survival mechanisms for antibiotic therapy resulting in failure of treatment in infection and disease cases. The Enterococcus species are potential strains implicated in gastrointestinal tract infection and are recently evolving in the resistance mechanism. The study evaluates the occurrence of New Delhi Metallo-beta-lactamase 1 (NDM-1) amongst Enterococcus species using the phenotypic and genomic characterization of environmental strains in the Oghara water nexus. Presumptive isolates of Enterococcus species were retrieved from various sampled water sources and confirmed using polymerase chain reaction (PCR). Antibiotic susceptibility testing was conducted on confirmed isolates using Kirby-Bauer disk diffusion methods. The result reveals 63 genus isolates confirmed Enterococcus species, of which 42 (67%) were Enterococcus faecium, 15 (23%) were Enterococcus faecalis, and 6 (10%) were other Enterococcus species. Fourteen among the E. faecalis isolates show resistance to Ertapenem-EDTA, while 17 (44.8%) of the E. faecium show resistance to Ertapenem-EDTA to presumptively reveal their NDM-1 phenotype. The PCR detection of the NDM-1 gene further confirmed 23 (36.5%) isolates as positive genotypes amongst the isolates that previously showed presumptive NDM-1 phenotype. It was also observed that 10 (15.9%) of Enterococcus faecium members harbored the NDM-1 genotype, whereas 8 (12.7%) members of the Enterococcus faecalis harbored the NDM-1 genotype. The observation of such resistance determinants necessitates a call for the adroit application of relevant therapeutics in the management of related infections and an environmental health caution to prevent the spread of such resistance potential enteric bacteria pathogens.
Diagnosis and Comparison of Three Invasive Detection Methods for Helicobacter pylori Infection
Authors: Kismat Saifa , Tanni Nusrat Nur , Akhtar Rokshana , Roy Chandan Kumar , Rahman Mohammad Mosiur , Molla Md. Maruf Ahmed , Anwar Shaheda , Ahmed Sharmeen
Published: October 2022

Background:

The purpose of this study was to compare different invasive methods for Helicobacter pylori ( H. pylori) detection, namely PCR for H. pylori specific ureC gene, Rapid urease test (RUT), and histopathological examination by modified Giemsa staining.

Methodology:

Endoscopic gastroduodenal biopsy materials were collected from dyspeptic patients who underwent endoscopic examination upon fulfilling the inclusion criteria. Three to four samples were collected from each patient after taking informed consent and proper clinical history. A rapid urease test (RUT) was done on spot with in-house RUT media from 1 specimen. One to two specimens were preserved in 10% formaldehyde for histopathology and PCR for ureC gene was done from 1 specimen. Collected biopsy specimens from gastric and duodenal mucosa of 142 patients were categorized as H. pylori-positive cases and H. pylori-negative cases based on the case definition used in the study upon positivity of 3 diagnostic tests.

Results:

Among 142 biopsy specimens, 34.5% were categorized as H. pylori-positive cases, 35.2% as H. pylori-negative cases, and finally 30.2% as doubtful or indeterminate cases. Rapid urease test was the most sensitive method, closely followed by ureC gene PCR and histopathology, with a sensitivity of 94.2%, 83.0%, and 76.5%, respectively. Whereas histology was the most specific, having 98.0% specificity followed by 83.0% in PCR. RUT was the least specific, with 55.5% specificity.

Conclusion:

While histopathology could detect H. pylori infection with the highest specificity, for definitive diagnosis combination of any 2 methods should be used, if available.
Species Differences in Tryptophan Metabolism and Disposition
Authors: Badawy Abdulla A-B , Guillemin Gilles J
Published: October 2022

Major species differences in tryptophan (Trp) metabolism and disposition exist with important physiological, functional and toxicity implications. Unlike mammalian and other species in which plasma Trp exists largely bound to albumin, teleosts and other aquatic species possess little or no albumin, such that Trp entry into their tissues is not hampered, neither is that of environmental chemicals and toxins, hence the need for strict measures to safeguard their aquatic environments. In species sensitive to toxicity of excess Trp, hepatic Trp 2,3-dioxygenase (TDO) lacks the free apoenzyme and its glucocorticoid induction mechanism. These species, which are largely herbivorous, however, dispose of Trp more rapidly and their TDO is activated by smaller doses of Trp than Trp-tolerant species. In general, sensitive species may possess a higher indoleamine 2,3-dioxygenase (IDO) activity which equips them to resist immune insults up to a point. Of the enzymes of the kynurenine pathway beyond TDO and IDO, 2-amino-3-carboxymuconic acid-6-semialdehyde decarboxylase (ACMSD) determines the extent of progress of the pathway towards NAD+ synthesis and its activity varies across species, with the domestic cat ( Felis catus) being the leading species possessing the highest activity, hence its inability to utilise Trp for NAD+ synthesis. The paucity of current knowledge of Trp metabolism and disposition in wild carnivores, invertebrates and many other animal species described here underscores the need for further studies of the physiology of these species and its interaction with Trp metabolism.
The contested meaning-making of diplomatic norms: competence in practice in Southeast Asian multilateralism
Authors: Martel Stéphanie , Glas Aarie
Published: October 2022

The supposedly fixed set of norms within the Association of Southeast Asian Nations (ASEAN), commonly referred to as the “ASEAN way,” is both celebrated and maligned as a key element of Southeast Asian diplomacy. In this article, we contest this orthodoxy through a practitioner-near account of ASEAN diplomatic norms in practice. We find that the “ASEAN way” is best understood as a rhetorical commonplace, a well-established topological resource that social agents use to advance and contest claims of competent diplomatic practice in the ASEAN community of practice. We build on and bridge insights from norm contestation, practice theory, and discourse literatures to develop an original framework for the study of contestation in communities of practice. Drawing from documentary evidence and 61 interviews with practitioners of ASEAN diplomacy, we illustrate our argument by examining contestation in practice in the context of the organization’s response to the Rohingya crisis and the South China Sea disputes.
Intersections of paranoia and the body in the general population
Authors: Toh Wei Lin , Phillipou Andrea , Neill Erica , Rossell Susan L
Published: October 2022

Negative body image may be associated with heightened feelings of paranoia. The current study aimed to conduct multidimensional assessments of body image and psychosis facets in the general population. Respondents were 407 individuals, who provided basic sociodemographic information, and completed online questionnaires evaluating dysmorphic concerns, body consciousness, paranoia, persecutory and magical ideation and perceptual aberration. Correlation analysis and a series of regressions onto various body image facets (i.e. dysmorphic concerns, private body consciousness, public body consciousness and body competence) were conducted. Distinct patterns of significant associations were uncovered across the range of body image and psychosis facets examined. Paranoia significantly contributed to the severity of dysmorphic concerns, and magical ideation significantly contributed to private and public body consciousness, though effect sizes were modest. Our findings corroborate the relationship between paranoia and dysmorphic concerns, and tentatively suggest that challenging paranoid beliefs could be a useful strategy for managing negative body image.
The Past Decade in Septuagint Research (2012–2021)
Authors: Ross William A.
Published: October 2022

This article overviews the very active past decade in the discipline of Septuagint scholarship, including publications dating from the beginning of 2012 through the end of 2021. It organizes and discusses this activity within numerous categories, beginning with a brief overview of previous disciplinary surveys before moving on to the many new publications that have appeared, including primary texts, commentaries, general introductions, handbooks and companions, and reference works. Further sections give attention to important trends and publications in the main disciplinary journal, as well as in the major conference volumes and series. The second half of the article gives attention to several important areas of development and debate in the discipline, with attention to how it has developed globally over the last ten years. In the course of this discussion, this article, while not exhaustive in scope or coverage, also contributes to the tradition within modern Septuagint scholarship of compiling a bibliography of scholarly publications in the discipline.
The Justice and Deliverance of God: Integrating Forensic and Cosmological in the ‘Apocalyptic Paul’
Authors: Davies Jamie
Published: October 2022

Recent ‘apocalyptic’ interpretations of Paul often highlight a distinction between ‘forensic’ and ‘cosmological’ varieties of apocalyptic eschatology. This essay surveys this phenomenon against the backdrop of the Bultmann/Käsemann debate. Various scholars have attempted to resolve the tension between these two poles, whether through circumscribing the forensic by the cosmological, or vice-versa, generating a spectrum of approaches within which this question is generally framed as a zero-sum game. This essay outlines a ‘non-competitive’ construal of this duality and examines a selection of integrative approaches in recent theological interpretation that allows for both forensic and cosmological aspects of Paul’s apocalyptic thought.
Do Denizens Represent Denizens? A Case of Foreigners’ Council in Frankfurt
Authors: Guasti Petra , Geißel Brigitte
Published: October 2022

This article fills a gap in existing research by focusing on the political representation of denizens—legal residents not holding citizenship of the country and thus generally excluded from legislative politics. The empirical research on the effects of the presence of under-represented groups in representative bodies indicates that “who represents” (descriptive) is as important as “what is being represented” (substantive). In this article, we analyze the extent to which an elected body of denizens (KAV) in the German city of Frankfurt provides a descriptive and substantive representation. We find that in Frankfurt, the body elected by denizens to represent denizens does not represent denizens. In providing inference about the descriptive and substantive representation of denizens in KAV, our research contributes to broadening the study of representation by focusing on an understudied group, non-traditional venues, and claim-making as a form of representative politics.
Examining the White Supremacist Practices of Funding Organizations for Public Health Research and Practice: A Composite Narrative From Female, BIPOC Junior Researchers in Public Health
Authors: Chen Elizabeth , Wallace Deshira , Leos Cristina , Merino Yesenia
Published: October 2022

Background. It is challenging for junior public health investigators who identify as Black, Indigenous, or People of Color (BIPOC) to secure funding for projects and research. We used a narrative inquiry approach to understand and present the funding cascade from the perspectives of female, junior BIPOC researchers and provide funders with actionable recommendations to advance their antiracist goals. Approach. We applied a Critical Race Theory (CRT) framework to guide our narrative inquiry approach. The participants were the four co-authors and we each drafted individual narratives around our experience with the funding cascade and subsequently the five stages of narrative analysis. Results. We created a visual representation of key activities for funders and applicants organized by our perceived magnitude of inequities in a journey map, an interpreter table that describes common phrases and barriers encountered, and a composite counternarrative presented as a group text message conversation, elevating common themes including feeling pressured to have our research agendas conform to funders’ interests and receiving limited key information and support in the funding process. Discussion. We discussed how our findings represented manifestations of White supremacy characteristics like power hoarding and paternalism. Implications for practice. We offered specific antidotes for funding organizations to make their processes more antiracist and invited leaders of public health funding organizations to join us to further identify antidotes and share lessons learned in Fall 2023.