bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparing consumer perceptions of appliances’ electricity use to appliances’ actual direct-metered consumption
Authors: Lesic Vedran , Glasgo Brock , Krishnamurti Tamar , Bruine de Bruin Wändi , Davis Matthew , Azevedo Inês Lima
Published: October 2019

Many strategies for reducing residential energy consumption—including product labelling programs, subsidies for the purchase of efficient devices, behavioral programs that encourage efficient energy use, and others—rely on building owners and end users to make informed investment and operational decisions. These strategies may be ineffective if consumers are unaware of how much electricity is used by different devices in their homes and buildings. This study therefore compares consumers’ perceptions of their appliances’ electricity use to these appliances’ actual direct-metered electricity consumption. Using an online survey, 118 homeowners from Austin, Texas were asked to estimate the energy consumption of six household devices which were monitored in the participants’ homes. Homeowners were randomly assigned to assess their appliance-specific electricity use in terms of energy units (kWh/month) or energy cost units ($/month) for an average summer month. Consistent with previous studies, participants overestimated the energy consumed by their low energy consuming devices and slightly underestimated that of their most energy-consuming device. Results also showed that responses of the experimental groups estimating their consumption in energy units and energy cost units were similar, the accuracy of the two groups’ perceptions was similar, and levels of confidence in the two groups were similar. These results suggest that targeted information campaigns focused on air conditioning energy consumption and device power reduction opportunities could improve consumer decision-making to save energy and reduce demand.
Current targeted therapies in lymphomas
Authors: Chung Clement
Published: October 2019

Purpose

This article summarizes current targeted therapies that have received regulatory approval for the treatment of B- and T-cell lymphomas.

Over the last 20 years, new drug therapies for lymphomas of B cells and T cells have expanded considerably. Targeted therapies for B-cell lymphomas include: (1) monoclonal antibodies directed at the CD20 lymphocyte antigen, examples of which are rituximab, ofatumumab, and obinutuzumab; (2) gene transfer therapy, an example of which is chimeric antigen receptor–modified T-cell (CAR-T) therapy directed at the CD19 antigen expressed on the cell surface of both immature and mature B cells; and (3) small-molecule inhibitors (ibrutinib, acalabrutinib, copanlisib, duvelisib, and idelalisib) that target the B-cell receptor signaling pathway. Of note, brentuximab vedotin is an antibody–drug conjugate that targets CD30, another lymphocyte antigen expressed on the cell surface of both Hodgkin lymphoma (a variant of B-cell lymphoma) and some T-cell lymphomas. Although aberrant epigenetic signaling pathways are present in both B- and T-cell lymphomas, epigenetic inhibitors (examples include belinostat, vorinostat, and romidepsin) are currently approved by the Food and Drug Administration for T-cell lymphomas only. In addition, therapies that target the tumor microenvironment have been developed. Examples include mogamulizumab, bortezomib, lenalidomide, nivolumab, and pembrolizumab. In summary, the efficacy of these agents has led to the development of supportive care to mitigate adverse effects, due to the presence of on- or off-target toxicities.

Conclusion

The therapeutic landscape of lymphomas has continued to evolve. In turn, the efficacy of these agents has led to the development of supportive care to mitigate adverse effects, due to the presence of on- or off-target toxicities. Further opportunities are warranted to identify patients who are most likely to achieve durable response and reduce the risk of disease progression. Ongoing trials with current and investigational agents may further elucidate their place in therapy and therapeutic benefits.
Tropical cyclones and the organization of mangrove forests: a review
Authors: Krauss Ken W , Osland Michael J
Published: October 2019

Background

Many mangrove ecosystems are periodically exposed to high velocity winds and surge from tropical cyclones, and often recover with time and continue to provide numerous societal benefits in the wake of storm events.

Scope

This review focuses on the drivers and disturbance mechanisms (visible and functional) that tropical cyclones of various intensities have on mangrove ecosystem properties around the world, as well as the potential ecosystem services role offered by mangroves along storm-ravaged coastlines. When viewed together, studies describe repeatable types of impact and a variety of responses of mangroves that make them ecologically resilient to high velocity winds, and which have served to advance the notion that mangroves are disturbance-adapted ecosystems.

Conclusions

Studies have documented massive tree mortality and forest structural shifts as well as high variability of spatial effects associated with proximity and direction of the tropical cyclone trajectory that influence biogeochemical processes, recovery of individual trees, and forest regeneration and succession. Mangroves provide coastal protection through surge and wind suppression during tropical cyclones, and yet are able to overcome wind effects and often recover unless some alternative environmental stress is at play (e.g. hydrological alteration or sedimentation). Structural elements of mangroves are influenced by the legacies imposed by past tropical cyclone injury, which affect their current appearance, and presumably their function, at any point in time. However, much is yet to be discovered about the importance of the effects of tropical cyclones on these fascinating botanical ecosystems, including the role of storm-based sediment subsidies, and much more effort will be needed to predict future recovery patterns as the frequency and intensity of tropical cyclones potentially change.
A cross-linguistic comparison of category verbal fluency test (ANIMALS): a systematic review
Authors: Ardila Alfredo
Published: October 2019

Background

Cross-linguistic information about performance in neuropsychological verbal tests is extremely scarce. It has been suggested that verbal fluency test using animal fluency test is one of the few tests fulfilling the fundamental criteria desirable in a robust neuropsychological test.

Objective

To compare and establish cross-linguistic information about performance in the animal fluency test.

Results

In an extensive search, it was found that norms for the semantic fluency test using the category ANIMALS are available in 15 different languages. These languages represent a relatively broad spectrum of world languages, including not only Indo-European languages, but also Semitic, Sino-Tibetan, Austroasiatic, Dravidian, and even Amerindian languages. Normative data in these 15 languages are analyzed and the results are compared.

Conclusions

It is concluded that (a) pure linguistic factors, such as type of language and word-length, seemingly do not significantly affect the performance in this test; (b) two major demographic variables—age and education—account for a significant percentage of the variance in this test; the effect of sex seems to be neglectable; (c) in bilinguals, when the native language has few speakers and/or is a marginalized language, a very low score can be observed in the native language, even lower than in the second language; (d) there is a frequently overlooked major factor accounting for differences in cognitive test performance: the effort made in performing the test. It depends on the significance given to the test performance. Effort is quite variable across cultures and is higher in psychometric-oriented societies.
Hawkmoth pollination of the orchid Habenaria clavata: mechanical wing guides, floral scent and electroantennography
Authors: Johnson Steven D , Balducci Marco G , Shuttleworth Adam
Published: October 2019

Floral morphology can play a key role in mechanically guiding pollinators towards reproductive structures, particularly when visibility is limited at night, but the functional significance of morphological traits has seldom been considered in this context. Here we describe a remarkably intricate pollination mechanism in the hawkmoth-pollinated African grassland orchid Habenaria clavata, and also document aspects of the reproductive success and chemical ecology of this pollination system. The flowers are pollinated by several short-tongued hawkmoths, particularly Basiothia schenki, which was the most frequent visitor and occurred at all sites. Moths are probably attracted by the strong scent, which was dominated by several oxygenated aromatics that also elicited strong electrophysiological responses from antennae of B. schenki. Apart from the white rostellum lobes and stigma, which serve as a visual guide to the spur entrance, the flower parts are entirely green and indistinguishable from leaves in terms of spectral information. Using motion-activated video cameras we established that the leading edges of the forewings of foraging hawkmoths contact the two upwardly curving petal lobes, and that hawkmoths are then apparently mechanically guided down onto the reproductive structures. Pollinaria are attached in an unusual place – among hairs on the ventral surface of the thorax, between the middle legs – and are brushed over the protruding stigma lobes when the proboscis is fully inserted in the 41-mm-long spur. These results highlight how multiple traits (morphology, spectral reflectance and scent) can act synergistically to ensure transfer of pollen among flowers.
Covariates of Burnout and Secondary Traumatisation in Professionals Working with Child Survivors of Trauma: A Research Synthesis
Authors: Vang Maria L , Gleeson Christina , Hansen Maj , Shevlin Mark
Published: October 2019

It has been demonstrated that working with trauma-exposed children increases the risk for developing secondary traumatisation (ST) and burnout (BO). High correlations between ST and BO have been reported, suggesting an empirical overlap between the constructs. The purpose of the present review was to synthesise research investigating covariates of BO and ST to explore whether this overlap extends to covariates. Seven research databases were searched for studies investigating covariates of both BO and ST. Identified studies were screened in accordance with predefined inclusion and exclusion criteria, resulting in thirteen articles being included for further review. Fourteen covariates were examined in two or more of the included studies and were synthesised according to the ‘levels of evidence approach’. Some individual and operational factors appeared to be equally related to BO and ST. There was a predominance of equivocal evidence for and against the salience of different covariates as well as an over-representation of demographic factors compared to organisational and operational factors in the current literature. More research investigating the nature of the overlap between BO and ST is needed, and future research would benefit from integrating covariates supported in the work and organisational literature with covariates from the psychotraumatological literature.
Push and pull of downstream moving juvenile sea lamprey (Petromyzon marinus) exposed to chemosensory and light cues
Authors: Johnson Nicholas S , Miehls Scott M , Haro Alex J , Wagner C Michael
Published: October 2019

Visual and olfactory stimuli induce behavioural responses in fishes when applied independently, but little is known about how simultaneous exposure influences behaviour, especially in downstream migrating fishes. Here, downstream moving juvenile sea lamprey (Petromyzon marinus) were exposed to light and a conspecific chemosensory alarm cue in a flume and movement were monitored with overhead cameras and nets. When exposed to light, sea lamprey were more likely to be captured in a net closest to the light array. When exposed to the alarm cue, sea lamprey transit rate through the flume increased, but sea lamprey did not avoid the alarm cue plume by moving perpendicular to flow. When the alarm cue and light were applied simultaneously in a push and pull configuration, the alarm cue still triggered enhanced downstream movement (push downstream) and more sea lamprey was still captured in the net nearest the light (pull to the side), resulting in twice as many sea lamprey being captured in the lighted net relative to controls. To our knowledge, this is the first study using multiple sensory cues in a push-pull configuration to modulate fish outmigration. Push and pull of juvenile sea lamprey with sensory cues could be useful to reduce turbine entrainment where native and enhance trap catch where invasive.
Financial Trouble Across Generations: Evidence from the Universe of Personal Loans in Denmark
Authors: Kreiner Claus Thustrup , Leth-Petersen Søren , Willerslev-Olsen Louise Charlotte
Published: October 2019

This article uses administrative data with longitudinal information about defaults for the entire Danish population to analyse the driving forces behind financial problems. Non-parametric evidence shows that the default propensity is more than four times higher for individuals with parents in default compared with that for individuals with parents not in default. This intergenerational relationship is apparent soon after children move into adulthood and become legally able to borrow, and is remarkably stable across parental income levels, childhood school performances, levels of loan balances and time periods. The evidence indicates that inherited financial behaviour is important for explaining differences in financial trouble.
Mini-extracorporeal circulation surgery produces less inflammation than off-pump coronary surgery
Authors: Permanyer Eduard , Munoz-Guijosa Christian , Padró Josep-Maria , Ginel Antonino , Montiel José , Sánchez-Quesada José Luis , Vila Luis , Camacho Mercedes
Published: October 2019

OBJECTIVES

Both off-pump coronary artery bypass grafting surgery (OPCABG) and mini-extracorporeal circulation (MECC) have been associated with lower morbidity and mortality and less inflammation than conventional cardiopulmonary bypass. However, studies comparing the 2 techniques are scarce and the results are controversial. We compared the clinical outcomes and inflammatory response of low-risk patients undergoing coronary bypass grafting with MECC versus OPCABG.

METHODS

We conducted a prospective, randomized study in patients undergoing coronary heart surgery. Two hundred and thirty consecutive low-risk patients were randomly assigned to either receive OPCABG (n = 117) or MECC (n = 113). Clinical outcomes and postoperative biochemical results were analysed in both groups. We also analysed 19 circulating inflammatory markers in a subgroup of 40 patients at 4 perioperative time points. The area under the curve for each marker was calculated to monitor differences in the inflammatory response.

RESULTS

No significant differences were found between groups regarding perioperative clinical complications and no deaths occurred during the trial. Plasma levels in 9 of the 19 inflammatory markers were undetectable or showed no temporal variation, 3 were higher in the MECC group [interleukin (IL)-10, macrophage inflammatory protein-1β and epidermal growth factor] and 7 were higher in the OPCABG group (growth regulator oncogene, IL-6, IL-8, soluble CD40 ligand, monocyte chemoattractant protein-1, monocyte chemoattractant protein-3 and tumour necrosis factor-α). Differences in 2 proinflammatory cytokines, IL-6 and monocyte chemoattractant protein 1, between the 2 surgical procedures were statistically significant.

CONCLUSIONS

No clinical differences were observed between in low-risk patients undergoing MECC or OPCABG surgery, but OPCABG was associated with an increased release of proinflammatory cytokines compared with MECC. Studies in larger cohorts and in patients at higher risk are needed to confirm these findings.

Clinical trial registration number

NCT02118025.
The effect of the 2008 recession on well-being and employment status of people with and without mental health problems
Authors: Jónsdóttir Unnur , þórðardóttir Edda Björk , Aspelund Thor , Jónmundsson þórarinn , Einarsdóttir Kristjana
Published: October 2019

Background

The world was hit hard by the 2008 recession which led to increased unemployment and financial strain. However, how the recession affected people with pre-existing mental health problems has been understudied. This study investigates the effect of the 2008 recession in Iceland on stress, well-being and employment status of people with regard to whether they are suffering from mental health problems.

Methods

The study cohort included participants (18–69 years old) of the ‘Health and Wellbeing of Icelanders’, a 3-wave survey conducted before (in 2007) and after (in 2009 and 2012) the recession in 2008. Self-assessed well-being was measured with the Short Warwick-Edinburgh Mental Well-being Scale and the 4-item Perceived Stress Scale. Logistic regression was used to assess the effect of the 2008 recession on self-assessed well-being and employment status in 2009 and 2012, using 2007 as a reference year.

Results

Participants with no pre-recession mental health problems were at increased risk of both poor well-being, (with adjusted odds ratio at 1.66, in 2009 and 1.64 in 2012) and higher perceived stress, (with adjusted odds ratio at 1.48 in 2009 and 1.53 in 2012), after the recession. Interestingly, no significant change in well-being and perceived stress was observed among participants suffering from pre-recession mental health problems. Both groups had increased risk of unemployment after the recession.

Conclusion

Results indicate that after recessions, the risk of stress and poor well-being increases only among those who do not suffer from pre-recession mental health problems.
The invasive ACGW Dryocosmus kuriphilus (Hymenoptera: Cynipidae) in Spain: native parasitoid recruitment and association with oak gall inducers in Catalonia
Authors: Jara-Chiquito Juan Luis , Askew Richard R , Pujade-Villar Juli
Published: October 2019

The Asian chestnut gall wasp (ACGW), Dryocosmus kuriphilus (Hymenoptera: Cynipidae), is an invasive pest that affects chestnut trees. The first record of this pest in Spain was in 2012, in Catalonia, and it is now distributed in virtually every chestnut growing area in the country. In this study, we present an overview of parasitoid recruitment by ACGW in Catalonia over a 4-year period (2013–2016) comparing parasitoid communities attacking galls on oak and chestnut trees at the same sites. A total of 22 species of native parasitoids that normally attack oak cynipids emerged from ACGW galls, together with the non-native Torymus sinensis. The most abundant species were Bootanomyia dorsalis, Torymus flavipes, Ormyrus pomaceus and Eupelmus urozonus. The study also found that 20 of the 22 native parasitoids in ACGW galls were also reared from galls of 13 species of oak gall inducer (12 Cynipidae, 1 Cecidomyiidae).
Impact of Mutation Rate and Selection at Linked Sites on DNA Variation across the Genomes of Humans and Other Homininae
Authors: Castellano David , Eyre-Walker Adam , Munch Kasper
Published: October 2019

DNA diversity varies across the genome of many species. Variation in diversity across a genome might arise from regional variation in the mutation rate, variation in the intensity and mode of natural selection, and regional variation in the recombination rate. We show that both noncoding and nonsynonymous diversity are positively correlated to a measure of the mutation rate and the recombination rate and negatively correlated to the density of conserved sequences in 50 kb windows across the genomes of humans and nonhuman homininae. Interestingly, we find that although noncoding diversity is equally affected by these three genomic variables, nonsynonymous diversity is mostly dominated by the density of conserved sequences. The positive correlation between diversity and our measure of the mutation rate seems to be largely a direct consequence of regions with higher mutation rates having more diversity. However, the positive correlation with recombination rate and the negative correlation with the density of conserved sequences suggest that selection at linked sites also affect levels of diversity. This is supported by the observation that the ratio of the number of nonsynonymous to noncoding polymorphisms is negatively correlated to a measure of the effective population size across the genome. We show these patterns persist even when we restrict our analysis to GC-conservative mutations, demonstrating that the patterns are not driven by GC biased gene conversion. In conclusion, our comparative analyses describe how recombination rate, gene density, and mutation rate interact to produce the patterns of DNA diversity that we observe along the hominine genomes.
Older Adults’ Self-Perceptions of Aging and Being Older: A Scoping Review
Authors: Hausknecht Simone , Low Lee-Fay , O’Loughlin Kate , McNab Justin , Clemson Lindy
Published: October 2019

Background and Objectives

Older adults’ self-perceptions of aging and being older can influence well-being and quality of life. This systematic scoping review aimed to map out current research on older adults’ self-perceptions of aging and being older.

Research Design and Methods

The scoping review followed Arksey and O’Malley’s methodological framework. A total of 5,037 records were identified (duplicates removed). After screening, a final 148 papers were included. Descriptives, including year of publication, methodology, age, gender, and location of participants, were calculated. Thematic analyses were conducted examining ways in which the topic was conceptualized.

Results

The most frequent method used in the research was quantitative. Participants were from 38 different countries. There were more female participants than male. Seven themes representing the main research emphasis emerged: attitudes towards one’s own aging (n = 48), aging well (n = 23), aging stereotypes, self-stigma (n = 23), construction of aging identities (n = 22), subjective age (n = 18), the aging body (n = 8), and future self-views (n = 6).

Discussion and Implications

The research within these themes approach self-perceptions of aging using varying points of reference for what participants compare their age to. The methods used to illicit aging perspectives held their own assumptions about aging.
Evidencing the relationship between injected volume of water and maximum expected magnitude during the Puerto Gaitán (Colombia) earthquake sequence from 2013 to 2015
Authors: Gómez Alba Sebastián , Vargas Carlos A , Zang Arno
Published: October 2019

Since 2013 to date more than 1000 seismic events have been recorded by the Servicio Geologico Colombiano (Colombian Geological Survey, SGC) in the municipality of Puerto Gaitán (Colombia). A total of 14 earthquakes are moment magnitude Mw > 4.0. The largest event ever recorded in the area occurred in November 2015 with Mw 4.8. It seems like the case of Puerto Gaitán is associated with the deep injection of coproduced wastewater from oil and gas extraction. The data presented in this work suggests a close relationship in space and time between injection operations and seismicity. An analysis of temporality between both data sets resulted in a time lag equivalent to about 218 d. For this paper, we computed the input and output energy during injection operations from 2013 to 2015 in order to estimate the fraction of total input energy that is radiated as seismic waves. Our results suggest that the seismic energy is only a small fraction of the total energy into the system. Although Puerto Gaitan is one of the places with the most significant volume of wastewater injected among the ones reported in the literature, the energy efficiency of the system is the lowest reported to date in comparison with other applied technologies. The low efficiency seems to be associated to the aseismic deformation of the reservoir rocks. The observed clustering of earthquakes is delimited by the basement crystalline depth. From an operational point of view, we determine that, like most cases associated with fluid injection, volume of fluid is the variable that determines change in the seismic moment released. Furthermore, the sequence of events in Puerto Gaitán may not fit into a well-known correlation between the volume of fluid injected and the maximum expected magnitude. The observed magnitudes in Puerto Gaitan are well bellow compared to those reported in the literature for similar volumes of injected fluid.
Using Conceptual Metaphors to Represent Temporal Context in Time Series Data Sonification
Authors: Roddy Stephen
Published: October 2019

This article explores how conceptual metaphor theory can be applied to the problem of representing temporal context in the sonification of time series data. It opens with an introduction to some of the conceptual metaphors involved in our understanding of time and music. Two of these metaphors are extended to the domain of Auditory Display and act as a guide to the creation of a design framework for representing temporal context in the sonification of time series data. An empirical listener evaluation of this framework is then presented and the results analysed to gauge the efficacy of this approach. The results suggest that the framework supports the listener, to a limited degree, in estimating which time-point they are currently hearing, how many time-points they have already heard and how many time-points they have left to hear. Improvements to the framework are suggested, and plans for future iterations are discussed.
Impact of Imidacloprid Soil Drenching on Survival, Longevity, and Reproduction of the Zoophytophagous Predator Podisus maculiventris (Hemiptera: Pentatomidae: Asopinae)
Authors: Resende-Silva Geverson A , Joseph Deney A , Guedes Raul Narciso C , Cutler G Christopher
Published: October 2019

Systemic insecticides when applied as seed treatments or soil drenches are often more toxicologically selective for natural enemies than target pests. This may not be the case, however, for omnivorous predators, which are at risk of extended exposure to systemically applied pesticides through ingestion while feeding on treated plants for nutrients or water. Such exposure may kill or have sublethal consequences for these natural enemies, compromising their role as biocontrol agents of agricultural pest species. The spined soldier bug, Podisus maculiventris (Say) (Hemiptera: Pentatomidae: Asopinae), is an important zoophytophagous biocontrol agent (i.e., able to substitute zoophagy by phytophagy for survival) that may be exposed to systemic insecticides in many agricultural systems. We, therefore, examined effects on P. maculiventris following exposure to cabbage plants subject to soil-drench treatments with imidacloprid, a systemic neonicotinoid insecticide. Predator survival, development, body weight, and reproduction were recorded. Imidacloprid significantly affected nymph survival and adult emergence, but not duration of the nymphal period or adult body weight. At one-twentieth the recommended field rate for whitefly and aphid management, imidacloprid treatments reduced longevity, fecundity, and fertility of female predators. These findings demonstrate that soil treatments with systemic insecticide can negatively impact zoophytophagous natural enemies.
Irish Heritage in the Literary Remains of Frank Yerby and Henry James
Authors: Garibaldi Korey
Published: October 2019

This essay investigates how Irish heritage—during the long historical epoch of British colonization—figured into the literary works of Frank Yerby and Henry James. Autobiographical connections and literary affinities between these authors are illuminated and contextualized by, among other published sources, the posthumous collection of essays by the latter novelist’s father, The Literary Remains of the late Henry James (1884). While scholars are newly investigating intersections between Henry James’s oeuvre and African American literature, Yerby’s enormously popular fiction has remained by and large estranged from this new direction in Jamesian studies. When read alongside Henry James, Sr.’s unfinished autobiography featured in the Literary Remains and related nonfictional texts, Yerby’s first novel and commercial best-seller, Foxes of Harrow (1946), seems to share an eerie amount in common with both the James family’s history and their humble Irish origins. Moreover, Yerby’s narrative curiously parallels the cross-racial solidarity the Jameses were regularly credited for in the one hundred years following the American Civil War.
CCL5 of glioma-associated microglia/macrophages regulates glioma migration and invasion via calcium-dependent matrix metalloproteinase 2
Authors: Yu-Ju Wu Caren , Chen Chia-Hua , Lin Chun-Yen , Feng Li-Ying , Lin Yung-Chang , Wei Kuo-Chen , Huang Chiung-Yin , Fang Jia-You , Chen Pin-Yuan
Published: October 2019

Background

Glioma-associated microglia/macrophages (GAMs) comprise macrophages of peripheral origin and brain-intrinsic microglia, which support tumor progression. Chemokine C-C ligand 5 (CCL5) is an inflammatory mediator produced by immune cells and is involved in tumor growth and migration in several cancers, including glioma. However, the mechanisms detailing how CCL5 facilitates glioma invasion remain largely unresolved.

Methods

Glioma migration and invasion were determined by wound healing, transwell assay, and 3D µ-slide chemotaxis assay. The expression levels of CCL5, CD68, matrix metalloproteinase 2 (MMP2), phosphorylated Ca2+/calmodulin-dependent protein kinase II (p-CaMKII), p-Akt, and phosphorylated proline-rich tyrosine kinase 2 were determined by cytokine array, quantitative PCR, western blot, or immunohistochemistry. Zymography and intracellular calcium assays were used to analyze MMP2 activity and intracellular calcium levels, respectively.

Results

CCL5 modulated the migratory and invasive activities of human glioma cells in association with MMP2 expression. In response to CCL5, glioma cells underwent a synchronized increase in intracellular calcium levels and p-CaMKII and p-Akt expression levels. CCL5-directed glioma invasion and increases in MMP2 were suppressed after inhibition of p-CaMKII. Glioma cells tended to migrate toward GAM-conditioned media activated by granulocyte-macrophage colony-stimulating factor (GM-CSF) in which CCL5 was abundant. This homing effect was associated with MMP2 upregulation, and could be ameliorated either by controlling intracellular and extracellular calcium levels or by CCL5 antagonism. Clinical results also revealed the associations between CCL5 and GAM activation.

Conclusion

Our results suggest that modulation of glioma CaMKII may restrict the effect of CCL5 on glioma invasion and could be a potential therapeutic target for alleviating glioma growth.
Comparison of the Clinical Characteristics of Hospital-Acquired and Non-Hospital-Acquired Acinetobacter calcoaceticus-baumannii Complex in a Large Midwest US Health Care System
Authors: Calix Juan J , Burnham Jason P , Feldman Mario F
Published: October 2019

We retrospectively compared the clinical characteristics of hospital-acquired (HA) vs non-hospital-acquired (nHA) Acinetobacter calcoaceticus-baumannii complex isolates in a large health care system in St. Louis, Missouri, from 2007 to 2017. More than 60% of the total isolates were nHA; they were predominantly from nonrespiratory sources and exhibited ~40% carbapenem resistance rates and stably persisted, though HA occurrence waned.
CO Multi-line Imaging of Nearby Galaxies (COMING). IV. Overview of the project
Authors: Sorai Kazuo , Kuno Nario , Muraoka Kazuyuki , Miyamoto Yusuke , Kaneko Hiroyuki , Nakanishi Hiroyuki , Nakai Naomasa , Yanagitani Kazuki , Tanaka Takahiro , Sato Yuya , Salak Dragan , Umei Michiko , Morokuma-Matsui Kana , Matsumoto Naoko , Ueno Saeko , Pan Hsi-An , Noma Yuto , Takeuchi Tsutomu T , Yoda Moe , Kuroda Mayu , Yasuda Atsushi , Yajima Yoshiyuki , Oi Nagisa , Shibata Shugo , Seta Masumichi , Watanabe Yoshimasa , Kita Shoichiro , Komatsuzaki Ryusei , Kajikawa Ayumi , Yashima Yu , Cooray Suchetha , Baji Hiroyuki , Segawa Yoko , Tashiro Takami , Takeda Miho , Kishida Nozomi , Hatakeyama Takuya , Tomiyasu Yuto , Saita Chey
Published: October 2019

Observations of the molecular gas in galaxies are vital to understand the evolution and star-forming histories of galaxies. However, galaxies with molecular gas maps of their whole discs at sufficient resolution to distinguish galactic structures are severely lacking. Millimeter-wavelength studies at a high angular resolution across multiple lines and transitions are particularly needed, severely limiting our ability to infer the universal properties of molecular gas in galaxies. Hence, we conducted a legacy project with the 45 m telescope of the Nobeyama Radio Observatory, called the CO Multi-line Imaging of Nearby Galaxies (COMING), which simultaneously observed 147 galaxies with high far-infrared (FIR) flux in 12CO, 13CO, and C18O J = 1–0 lines. The total molecular gas mass was derived using the standard CO–to–H2 conversion factor and found to be positively correlated with the total stellar mass derived from the WISE 3.4 μm band data. The fraction of the total molecular gas mass to the total stellar mass in galaxies does not depend on their Hubble types nor the existence of a galactic bar, although when galaxies in individual morphological types are investigated separately, the fraction seems to decrease with the total stellar mass in early-type galaxies and vice versa in late-type galaxies. No differences in the distribution of the total molecular gas mass, stellar mass, or the total molecular gas to stellar mass ratio was observed between barred and non-barred galaxies, which is likely the result of our sample selection criteria, in that we prioritized observing FIR bright (and thus molecular gas-rich) galaxies.
Does Integrative Medicine Reduce Prescribed Opioid Use for Chronic Pain? A Systematic Literature Review
Authors: Hassan Samah , Zheng Qingping , Rizzolo Erica , Tezcanli Evrim , Bhardwaj Sukriti , Cooley Kieran
Published: October 2019

Background

Chronic pain (CP) is a major public health problem. Many patients with CP are increasingly prescribed opioids, which has led to an opioid crisis. Integrative medicine (IM), which combines pharmacological and complementary and alternative medicine (CAM), has been proposed as an opioid alternative for CP treatment. Nevertheless, the role of CAM therapies in reducing opioid use remains unclear.

Objectives

To explore the effectiveness of the IM approach or any of the CAM therapies to reduce or cease opioid use in CP patients.

Methods

An online search of MEDLINE and Embase, CINAHL, PubMed supp., and Allied and Complementary Medicine Database (AMED) for studies published in English from inception until February 15, 2018, was conducted. The Mixed Methods Appraisal Tool (MMAT) was used to critically appraise selected studies.

Results

The electronic search yielded 5,200 citations. Twenty-three studies were selected. Eight studies were randomized controlled trials, seven were retrospective studies, four studies were prospective observational, three were cross-sectional, and one was quasi-experimental. The majority of the studies showed that opioid use was reduced significantly after using IM. Cannabinoids were among the most commonly investigated approaches in reducing opioid use, followed by multidisciplinary approaches, cognitive-behavioral therapy, and acupuncture. The majority of the studies had limitations related to sample size, duration, and study design.

Conclusions

There is a small but defined body of literature demonstrating positive preliminary evidence that the IM approach including CAM therapies can help in reducing opioid use. As the opioid crisis continues to grow, it is vital that clinicians and patients be adequately informed regarding the evidence and opportunities for IM/CAM therapies for CP.
Validating reported cause of death using integrated electronic health records from a nation-wide database
Authors: Leventer-Roberts Maya , Haklai Ziona , Applbaum Yael , Goldberger Nehama , Cohen Dror , Levinkron Ohad , Feldman Becca , Balicer Ran
Published: October 2019

Background

To compare the underlying cause of death reported by the Israeli Central Bureau of Statistics (CBS) with diagnoses in the electronic health records (EHR) of a fully integrated payer/provider healthcare system.

Methods

Underlying cause of death was obtained from the CBS for deaths occurring during 2009–2012 of all Clalit Health Service members in Israel. The final cohort consisted of members who had complete medical records. The frequency of a supportive diagnosis in the EHR was reported for 10 leading causes of death (malignancies, heart disease, cerebrovascular disease, diabetes, kidney disease, septicemia, accidents, chronic lower respiratory disease, dementia and pneumonia and influenza).

Results

Of the 45 680 members included in the study, the majority of deaths had at least one diagnosis in the EHR that could support the cause of death. The lowest frequency of supportive diagnosis was for septicemia (52.2%) and the highest was for malignancies (94.3%). Sensitivity analysis did not suggest an alternative explanation for the missing documentation.

Conclusions

The underlying cause of death coded by the CBS is often supported by diagnoses in Clalit’s EHR. Exceptions are septicemia or accidents that cannot be anticipated from a patient’s EHR, and dementia which may be under-reported.
Knowledge and values: A re-entanglement in epistemic regimes
Authors: Feldbacher-Escamilla Christian J
Published: October 2019

Knowledge and values are the two main ingredients of public decision-making. In the past, the predominant paradigm of such decision-making was based on an approach of value-neutral science and aimed at processing both ingredients in a disentangled way. However, this approach has some theoretical and practical drawbacks, for which reason several alternative paradigms of public decision-making arose. In this paper we highlight the importance of another paradigm of such decision-making within so-called epistemic regimes. We do so against the background of the discussion of value-neutral science and provide a conceptual analysis of the notion of a regime which allows us to outline the underlying structure of re-entangling knowledge and values in epistemic regimes.
The Constitutional Price for International Unilateralism in the European Banking Union
Authors: Dumitrescu-Pasecinic Adrian
Published: October 2019

In order to enter the Banking Union, non-euro EU Member States must ‘step outside’ the EU legal order and the Union’s institutional framework, and resort to unilateral instruments of public international law. If the intergovernmental method has advanced the alternative project of integration based on voluntary policy, international unilateralism is seen as a similar integration technique based on the voluntary action of non-euro Member States, ie a tool for deeper integration that appears as a variation of intergovernmentalism. This article focuses on the constitutional deficiencies caused by the choice of unilateral instruments in the institutional set-up of a close cooperation arrangement in the Single Supervisory Mechanism. At first sight, leaving the EU legal order and entering the world of international law opens entirely new perspectives for the participating Member States. The possible attraction is escaping the constraining institutional framework of EU law. However, the international law route poses significant constitutional challenges vis-à-vis compatibility with the EU law.
Time Contribution of Social Workers in Care Management
Authors: Rowe Jeannine M. , Rizzo Victoria M. , Kang Suk-Young , Kukowski Rebekah , Ewald Bonnie , Newman Michelle , Golden Robyn
Published: October 2019

Purpose of the Study:

The purpose of this study was to examine the time contribution of social workers in delivering AIMS (Ambulatory Integration of the Medical and Social), a care management protocol designed to address patients' nonmedical needs, and the association of time contribution with patients' depression outcomes.

Primary Practice Setting:

The study was conducted in 6 primary care provider clinics housed in a large, urban academic medical center located in the Midwestern United States.

Methodology and Sample:

A longitudinal, quasi-experimental study employing survey procedures and a retrospective review of patient records was conducted. The study included 340 patients 50 years and older with unmet nonmedical needs. Half of the patients received AIMS, which was delivered by social workers. The other half received usual care (UC), which was delivered by other health care providers.

Results:

Chi-square analysis and independent-samples t tests were performed to compare time spent addressing nonmedical needs with differences in patients' depression levels at 6 months postenrollment. The findings reveal that social workers spend significantly more time with patients than UC providers addressing patients' nonmedical needs (p < .0001). At 6 months postintervention, reduced levels of depression were observed for AIMS patients when compared with UC patients (p = .026).

Implications for Care Management Practice:

Including social workers as part of health care teams is valuable. Time spent with patients and engaging in care management activities to support patients' needs is linked with positive health outcomes. Given the benefits of care management, opportunities for reimbursement are enhanced.
Science Map of Cochrane Systematic Reviews Receiving the Most Altmetric Attention: Network Visualization and Machine Learning Perspective
Authors: Kolahi Jafar , Khazaei Saber , Bidram Elham , Kelishadi Roya , Iranmanesh Pedram , Nekoofar Mohammad H. , Dummer Paul M. H.
Published: October 2019

We aimed to analyze and visualize the science map of Cochrane systematic reviews (CSR) with high Altmetric attention scores (AAS). On 10 May 2019, the Altmetric data of the CSR Database were obtained from the Altmetric database (Altmetric LLP, London, UK). Bibliometric data of the top 5% of CSR were extracted from the Web of Science. Keyword co-occurrence, co-authorship, and co-citation network analysis were then employed using VOSviewer software. A Random forest model was used to analyze the citation patterns. A total of 12016 CSR with AAS were found (Total mentions: 259968) with Twitter being the most popular Altmetric resource. Consequently, the top 5% (607 articles, mean AAS: 171.2, 95% confidence level (CL): 14.4, mean citations: 42.1, 95%CL: 1.3) with the highest AAS were included in the study. Keyword co-occurrence network analysis revealed female, adult, and child as the most popular keywords. Helen V. Worthington (University of Manchester, Manchester, UK), and the University of Oxford and UK had the greatest impact on the network at the author, organization and country levels respectively. The co-citation network analysis revealed that The Lancet and CSR database had the most influence on the network. However, AAS were not correlated with citations (r=0.15) although they were correlated with policy document mentions (r=0.61). The results of random forest model confirmed the importance of policy document mentions. Despite the popularity of CSR in the Twittersphere, disappointingly, they were rarely shared and discussed within the new academic tools that are emerging, such as F1000 prime, Publons, and PubPeer.

Article Highlights

The CSR database was most mentioned in Twitter.

Twitter and News act as the greatest prominent issues regarding altmetric scores.
MicroRNA-mRNA networks define translatable molecular outcome phenotypes in osteosarcoma
Authors: Lietz Christopher E. , Garbutt Cassandra , Barry William T. , Deshpande Vikram , Chen Yen-Lin , Lozano-Calderon Santiago A. , Wang Yaoyu , Lawney Brian , Ebb David , Cote Gregory M. , Duan Zhenfeng , Hornicek Francis J. , Choy Edwin , Nielsen G. Petur , Haibe-Kains Benjamin , Quackenbush John , Spentzos Dimitrios
Published: October 2019

Background

There is a lack of well validated biomarkers in osteosarcoma, a rare, recalcitrant disease with variable outcome and poorly understood biologic behavior, for which treatment standards have stalled for decades. The only standard prognostic factor in osteosarcoma remains the amount of pathologic necrosis following pre-operative chemotherapy, which does not adequately capture the biologic complexity of the tumor and has not resulted in optimized patient therapeutic stratification. New, robust biomarkers are needed to understand prognosis and better reflect the underlying biologic and molecular complexity of this disease.

Methods

We performed microRNA sequencing in 74 frozen osteosarcoma biopsy samples, the largest single center translationally analyzed cohort to date, and separately analyzed a multi-omic dataset from a large (n = 95) NCI supported national cooperative group cohort. Molecular patterns were tested for association with outcome and used to identify novel therapeutics for further study by integrative pharmacogenomic analysis.

Results

MicroRNA profiles were found predict Recurrence Free Survival (5-microRNA profile, Median RFS 59 vs 202 months, log rank p=0.06, HR 1.87, 95% CI 0.96-3.66). The profiles were independently prognostic of RFS when controlled for metastatic disease at diagnosis and pathologic necrosis following chemotherapy in multivariate Cox proportional hazards regression (5-microRNA profile, HR 3.31, 95% CI 1.31–8.36, p=0.01). Strong trends for survival discrimination were observed in the independent NCI dataset, and transcriptomic analysis revealed the downstream microRNA regulatory targets are also predictive of survival (median RFS 17 vs 105 months, log rank p=0.007). Additionally, DNA methylation patterns held prognostic significance. Through machine learning based integrative pharmacogenomic analysis, the microRNA biomarkers identify novel therapeutics for further study and stratified application in osteosarcoma.

Conclusions

Our results support the existence of molecularly defined phenotypes in osteosarcoma associated with distinct outcome independent of clinicopathologic features. We validated candidate microRNA profiles and their associated molecular networks for prognostic value in multiple independent datasets. These networks may define previously unrecognized osteosarcoma subtypes with distinct molecular context and clinical course potentially appropriate for future application of tailored treatment strategies in different patient subgroups.
GEMtractor: Extracting Views into Genome-scale Metabolic Models
Authors: Scharm Martin , Wolkenhauer Olaf , Jalili Mahdi , Salehzadeh-Yazdi Ali
Published: October 2019

Computational metabolic models typically encode for graphs of species, reactions, and enzymes. Comparing genome-scale models through topological analysis of multipartite graphs is challenging. However, in many practical cases it is not necessary to compare the full networks. The GEMtractor is a web-based tool to trim models encoded in SBML. It can be used to extract subnetworks, for example focusing on reaction- and enzyme-centric views into the model.

Availability and Implementation

The GEMtractor is licensed under the terms of GPLv3 and developed at github.com/binfalse/GEMtractor – a public version is available at sbi.uni-rostock.de/gemtractor.

Contact

martin.scharm@uni-rostock.de and ali.salehzadeh-yazdi@uni-rostock.de