bluuebunny/crossref_metadata_2025 huggingface dataset:
Lung Metastasis Probability in Ewing Sarcoma: A Nomogram Based on the SEER Database
Authors: Wang Jie , Fan Yonggang , Xia Lei
Published: January 2021

Background. Up to now, an accurate nomogram to predict the lung metastasis probability in Ewing sarcoma (ES) at initial diagnosis is lacking. Our objective was to construct and validate a nomogram for the prediction of lung metastasis in ES patients. Methods. A total of 1157 patients with ES from the Surveillance, Epidemiology, and End Results (SEER) database were retrospectively collected. The predictors of lung metastasis were identified via the least absolute shrinkage and selection operator (LASSO) and multivariate logistic analysis. The discrimination and calibration of the nomogram were validated by receiver operating characteristic (ROC) curve and calibration curve. Decision curve analysis (DCA) was used to evaluate the clinical usefulness and net benefits of the prediction model. Results. Factors including age, tumor size, primary site, tumor extension, and other site metastasis were identified as the ultimate predictors for the nomogram. The calibration curves for the training and validation cohorts both revealed good agreement, and the Hosmer–Lemeshow test identified that the model was well fitted (p > 0.05). In addition, the area under the ROC curve (AUC) values in the training and validation cohorts were 0.732 (95% confidence interval, CI: 0.607–0.808) and 0.741 (95% CI: 0.602–0.856), respectively, indicating good predictive discrimination. The DCA showed that when the predictive metastasis probability was between 1% and 90%, the nomogram could provide clinical usefulness and net benefit. Conclusion. The nomogram constructed and validated by us could provide a convenient and effective tool for clinicians that can improve prediction of the probability of lung metastasis in patients with ES at initial diagnosis.
Primary Mediastinal Germ Cell Tumors—The University of Western Ontario Experience
Authors: Lavi Arnon , Winquist Eric , Nair Shiva M. , Chin Joseph L. , Izawa Jonathan , Fernandes Ricardo , Ernst Scott , Power Nicholas E.
Published: January 2021

Extragonadal germ cell tumors account for 2–5.7% of germ cell tumors (GCTs). Of these, primary mediastinal GCTs (PMGCTs) are responsible for 16–36% of cases. Given the rarity of these tumors, specific treatment strategies have not been well defined. We report our experience in treating these complex patients. In total, 318 men treated at our institution with chemotherapy for GCTs between 1980 and 2016 were reviewed. PMGCT was defined as clinically diagnosed mediastinal GCT with no evidence of testicular GCT (physical exam/ultrasound). We identified nine patients diagnosed with PMGCT. All patients presented with an anterior mediastinal mass and no gonadal lesion; four patients also had metastatic disease. Median age at diagnosis was 30 years (range, 14–56) and median mass size at diagnosis was 9 cm (range, 3.4–19). Eight patients had non-seminoma and one had pure seminoma. All patients received cisplatin-based chemotherapy initially. Surgical resection was performed in four patients; three patients had a complete resection and one patient was found to have an unresectable tumor. At a median follow-up of 2 years (range, 3 months–28 years) six patients had progressed. Progression-free survival was short with a median of 4.1 months from diagnosis (range 1.5–122.2 months). Five patients died at a median of 4.4 months from diagnosis. One and 5-year overall survivals were 50% and 38%, respectively. PMGCT are rare and aggressive. Our real-life Canadian experience is consistent with current literature suggesting that non-seminoma PMGCT has a poor prognosis despite prompt cisplatin-based chemotherapy followed by aggressive thoracic surgery.
The Prognostic Value of Neutrophil-to-Lymphocyte Ratio in Metastatic Testicular Cancer
Authors: Ribnikar Domen , Stukalin Igor , Bedard Philippe L. , Hamilton Robert J. , Jewett Michael , Warde Padraig , Chung Peter , Anson-Cartwright Lynn , Templeton Arnoud J. , Amir Eitan , Hansen Aaron R. , Heng Daniel Y. C. , Lewin Jeremy
Published: January 2021

We investigated the prognostic utility of pre-chemotherapy neutrophil-to-lymphocyte ratio (NLR) in patients with metastatic germ cell tumors (GCTs) undergoing first-line chemotherapy. We utilized two institutional databases to analyze the pretreatment-derived NLR (dNLR). Predictive accuracy was evaluated using the Cox proportional hazard model adjusted for the international germ cell cancer collaborative group (IGCCCG) risk classification. Discriminatory accuracy was evaluated by determining the area under the receiver operating characteristic curve (AUROC). In total, 569 of 690 patients had available dNLR (IGCCCG: good, 64%; intermediate, 21%; poor, 16%). The 5-year and 10-year overall survivals (OSs) for good, intermediate, and poor risk groups were 96.2%, 92.8%, and 62.7% and 93.9%, 90.3%, and 62.7%, respectively. A dNLR of 2 provided the best discriminatory accuracy with an AUROC of 0.58 (95% CI: 0.52–0.65, p = 0.01) for progression-free survival (PFS), whereas for OS, a dNLR of 3 provided the best discriminatory accuracy with an AUROC of 0.62 (95% CI: 0.53–0.70, p < 0.01). A dNLR > 2 was associated with a hazard ratio (HR) of 1.99 (95% CI: 1.27–3.12, p < 0.01) for PFS, which lost its effect after adjustment for IGCCCG (HR: 1.44, 95% CI: 0.90–2.30, p = 0.13). For OS, a dNLR >3 was associated with an HR of 3.00 (95% CI: 1.79–5.01, p < 0.01), but lost its effect after adjustment for IGCCCG. Systemic inflammation plays a role in metastatic GCT, but its prognostic utility beyond established algorithms is limited. The general prognostic value of NLR can be seen across a number of tumors, although the consistency and magnitude of the effect differ according to cancer type, disease stage, and treatment received. We identified that an elevated NLR was associated with an adverse PFS and OS, but not independent of the IGCCCG risk classification. dNLRs >2 and >3 were associated with an adverse PFS and OS, respectively, in patients with metastatic GCT receiving first-line chemotherapy, but not independent of the IGCCCG risk classification.
Risk of Thrombosis in Adult Philadelphia-Positive ALL Treated with an Asparaginase-Free ALL Regimen
Authors: Chen Ruiqi , Liu Xing , Law Arjun D. , Kanfar Solaf , Maze Dawn , Chan Steven M. , Gupta Vikas , Yee Karen W. , Minden Mark D. , Schimmer Aaron D. , Schuh Andre C. , McNamara Caroline J. , Murphy Tracy , Xu Anna , Falcone Umberto , Seki Jack , Sibai Hassan
Published: January 2021

Background: venous thromboembolism (VTE) is a well-known complication in adults with acute lymphoblastic leukemia (ALL), especially in patients treated with asparaginase (ASNase)-including regiments. However, VTE risk in adult Philadelphia-positive ALL (Ph+ve ALL) patients treated with non-hyperCVAD chemotherapy is unclear. In this study, we examined VTE incidence in adult Ph+ve ALL patients treated with imatinib plus a pediatric-inspired asparaginase (ASNase)-free regimen modified from the Dana Farber Cancer Institute (DFCI) ALL protocol. Methods: a single centre retrospective review of Ph+ve ALL patients treated at Princess Margaret Cancer Center (PMCC) from 2008–2019 with imatinib plus modified DFCI protocol was conducted. Results: of the 123 patients included, 30 (24.3%) had at least 1 radiology confirmed VTE event from diagnosis to the end of maintenance therapy. 86.7% (26/30) of the VTE events occurred during active treatment. Of all VTE events, the majority (53.3%) were DVT and/or PE while another significant portion were catheter-related (40.0%). Major bleeding was observed in 1 patient on VTE treatment with low molecular weight heparin (LMWH). Conclusion: a high VTE incidence (24.3%) was observed in adults Ph+ve ALL patients treated with imatinib plus an ASNase-free modified DFCI pediatric ALL protocol, suggesting prophylactic anticoagulation should be considered for all adult Ph+ve ALL patients including those treated with ASNase-free regimens.
Successful Management of Natalizumab-Associated Primary Central Nervous System Lymphoma through Autologous Stem Cell Transplant
Authors: Moineau-Vallée Karine , Rinfret Justine , Luu Hoai My Hanh , St-Louis Valérie , Berthelet France , Létourneau-Guillon Laurent , Lemieux-Blanchard Émilie , Prat Alexandre , Adam Jean-Philippe
Published: January 2021

Natalizumab is used as a second-line treatment for multiple sclerosis (MS). Some reports have linked natalizumab to primary central nervous system lymphoma (PCNSL), although few have described its management. A 45-year-old woman with Balo’s Concentric Sclerosis presented dizziness, vertigo accompanied by dysarthria, weakness on the left side and blurred vision to the right eye after the fourth dose of natalizumab. Magnetic resonance imaging (MRI) and a brain biopsy confirmed the diagnosis of PCNSL. The patient received modified PCNSL chemotherapy (MATRix protocol) followed by high-dose chemotherapy (HDC) supported by an autologous hematopoietic stem cell transplant (ASCT) as a consolidation therapy. Thirty months later, she is still in complete remission of her PCNSL and MS. In this case, whole brain radiotherapy was excluded because it may be associated with an increased risk of neurotoxicity in MS. ASCT was preferred because it has been shown to prevent disability progression in less advanced MS stages. Our patient is the second to receive an ASCT in this context and this option of treatment should be the preferred if the patient is eligible.
Reevaluating Patient Eligibility for Inotuzumab Ozogamicin Based on CD22 Expression: Is Dim Expression Sufficient?
Authors: Fingrut Warren , Davis Wendy , McGinnis Eric , Dallas Karen , Ramadan Khaled , Merkeley Hayley , Leitch Heather , Abou Mourad Yasser , Cassaday Ryan D. , Ross Camilla , Léger Chantal
Published: January 2021

Salvage options for patients with relapsed B-cell acute lymphoblastic leukemia (B-ALL) include inotuzumab ozogamicin (InO), a recombinant, humanized anti-CD22 monoclonal antibody conjugated to the cytotoxic antibiotic calicheamicin. However, the benefit of InO in patients with dim CD22 expression remains unclear. We present a case of a patient with B-ALL who responded to InO despite only dim surface expression of CD22 by flow cytometry, achieving a survival benefit concordant with that reported in the literature and maintaining a good quality of life as a transfusion-independent outpatient. Our observation has broad relevance to clinicians who manage patients with B-ALL who are candidates for InO.
Adding Three Cycles of CAPOX after Neoadjuvant Chemoradiotherapy Increases the Rates of Complete Response for Locally Advanced Rectal Cancer
Authors: Zhai Zhiwei , Zhang Kunning , Wang Chen , Zhang Tian , Wang Lixia , Yao Jiannan , Wang Zhenjun
Published: January 2021

Background and Objectives: the total neoadjuvant chemoradiotherapy (TNT) includes different strategies, but the most appropriate model remains uncertain. The purpose of this retrospectively study was to evaluate the safety and pathological response in the consolidation chemotherapy model. Methods: patients with cT3/T4 or TxN + M0 rectal cancer that were receiving neoadjuvant chemoradiotherapy (CRT) (50 Gy with oral capecitabine)/TNT (CRT followed by three cycles of CAPOX) during September 2017 to September 2019 in our department were included. All of the patients were recommended to receive radical surgery. Results: a total of 197 patients were included. Eighty-one patients received CRT, while one hundred and sixteen patients received TNT. Nine patients did not undergo surgery because of the distant metastases (one patient (1.2%) in CRT group, two patients (1.7%) in TNT group) or a refusal of resection (two patients in CRT group, four patients in TNT group). The pathological complete response (pCR) rate was 32.7% in TNT compared with 12.8% in CRT (p = 0.002). There was no statistically significant difference in grade 3 acute toxicities of neoadjuvant treatment and surgical complications between the two groups. Conclusions: the consolidation chemotherapy model is safe for patients with locally advanced rectal cancer and it has a high pCR rate. The long-term follow-up is necessary to be evaluated in a future prospective, randomized trial.
The Impact of Radiotherapy on the Incidence of Secondary Malignancies: A Pan-Cancer Study in the US SEER Cancer Registries
Authors: Li Wei , Xiao Haitao , Xu Xuewen , Zhang Yange
Published: January 2021

The population of cancer patients with second primary malignancies (SPMs) is rapidly growing. The relationship between radiotherapy and SPMs for some types of tumors is unknown or debated. In this study, we identify 24 types of first primary malignancies (FPMs) between 2004 and 2015 in the Surveillance, Epidemiology, and End Results (SEER) database. Patients in the radiotherapy group were matched to those in the no radiotherapy group with a matching ratio of 1:1. After propensity-score matching (PSM), additional competing risk regression analyses were performed to calculate the efficacy of radiotherapy to SPMs in the PSM-adjusted population. In addition, the Fine and Gray model was utilized in the primary cohorts, and stratified analyses were performed based on surgery. This study includes a total of 2,831,789 eligible patients with tumors diagnosed from 2004 to 2015 in the SEER 18 database, amongst whom 100,194 (3.5%) patients developed SPMs. We observe higher risks of SPMs associated with radiotherapy in several types of tumors in the PSM-adjusted populations (small bowel adenocarcinoma, small cell lung carcinoma, prostate adenocarcinoma, urinary bladder transitional cell carcinoma, invasive ductal breast carcinoma, invasive lobular breast carcinoma, and Hodgkin lymphoma). The results in the PSM-adjusted populations were consistent with outcomes in the multivariable competing risk models. Meanwhile, in subgroup analyses stratified by surgery, some other types of tumor (except for those with positive results in the PSM-adjusted cohorts) with radiotherapy were also associated with a higher prevalence of SPMs in the subgroups of surgical treatment (pancreatic adenocarcinoma, rectal adenocarcinoma, lung adenocarcinoma and follicular thyroid carcinoma in the surgery subgroups). The impact of radiotherapy on the incidence of secondary malignancies is distinct in different types of cancer. These findings merit further investigation and may ultimately impact treatment decision-making for tumor management.
A Rare Coexistence of Paraneoplastic Cerebellar Degeneration: Papillary Thyroid Carcinoma
Authors: Ayas Zeynep Özözen , Uncu Gülgün
Published: January 2021

Paraneoplastic cerebellar degeneration (PCD) is a rare neuroimmunological disease that may accompany tumors. In this article, we present a patient with progressive gait difficulty who was diagnosed with PCD and, in a rare comorbidity, with papillary thyroid carcinoma (PTC) following malignancy screening. A 46-year-old male patient reported having experienced poor balance for 2 years. A neurological examination revealed nystagmus, intention tremor, and ataxia, and anti-thyroid peroxidase and anti-thyroglobulin levels were found to be elevated. A brain MRI showed significant cerebellar atrophy in the superior vermis. Malignancy screening for PCD was performed, and thyroid ultrasonography revealed a nodule in the left lobe, while PET/CT detected elevated focal F-18 fluorodeoxyglucose uptake in the thyroid. Onconeuronal antibodies (anti-Hu, anti-Yo, anti-Ri, anti-amphiphysin, anti-Tr, anti-PPCA-2, anti-Ma, anti-CV-1, and anti-ANNA-3) were negative. Pathologic examination of the thyroid revealed PTC, for which the patient was treated with 0.4 g/kg intravenous immunoglobulin and referred to the medical oncology department. This case demonstrates that clinicians must be alert to the rare comorbidity of PCD and PTC.
On the Scope of Lagrangian Vortex Methods for Two-Dimensional Flow Simulations and the POD Technique Application for Data Storing and Analyzing
Authors: Kuzmina Kseniia , Marchevsky Ilia , Soldatova Irina , Izmailova Yulia
Published: January 2021

The possibilities of applying the pure Lagrangian vortex methods of computational fluid dynamics to viscous incompressible flow simulations are considered in relation to various problem formulations. The modification of vortex methods—the Viscous Vortex Domain method—is used which is implemented in the VM2D code developed by the authors. Problems of flow simulation around airfoils with different shapes at various Reynolds numbers are considered: the Blasius problem, the flow around circular cylinders at different Reynolds numbers, the flow around a wing airfoil at the Reynolds numbers 104 and 105, the flow around two closely spaced circular cylinders and the flow around rectangular airfoils with a different chord to the thickness ratio. In addition, the problem of the internal flow modeling in the channel with a backward-facing step is considered. To store the results of the calculations, the POD technique is used, which, in addition, allows one to investigate the structure of the flow and obtain some additional information about the properties of flow regimes.
Dynamics of Ion Channels via Non-Hermitian Quantum Mechanics
Authors: Gulden Tobias , Kamenev Alex
Published: January 2021

We study dynamics and thermodynamics of ion transport in narrow, water-filled channels, considered as effective 1D Coulomb systems. The long range nature of the inter-ion interactions comes about due to the dielectric constants mismatch between the water and the surrounding medium, confining the electric filed to stay mostly within the water-filled channel. Statistical mechanics of such Coulomb systems is dominated by entropic effects which may be accurately accounted for by mapping onto an effective quantum mechanics. In presence of multivalent ions the corresponding quantum mechanics appears to be non-Hermitian. In this review we discuss a framework for semiclassical calculations for the effective non-Hermitian Hamiltonians. Non-Hermiticity elevates WKB action integrals from the real line to closed cycles on a complex Riemann surfaces where direct calculations are not attainable. We circumvent this issue by applying tools from algebraic topology, such as the Picard-Fuchs equation. We discuss how its solutions relate to the thermodynamics and correlation functions of multivalent solutions within narrow, water-filled channels.
An Entropy Metric for Regular Grammar Classification and Learning with Recurrent Neural Networks
Authors: Zhang Kaixuan , Wang Qinglong , Giles C. Lee
Published: January 2021

Recently, there has been a resurgence of formal language theory in deep learning research. However, most research focused on the more practical problems of attempting to represent symbolic knowledge by machine learning. In contrast, there has been limited research on exploring the fundamental connection between them. To obtain a better understanding of the internal structures of regular grammars and their corresponding complexity, we focus on categorizing regular grammars by using both theoretical analysis and empirical evidence. Specifically, motivated by the concentric ring representation, we relaxed the original order information and introduced an entropy metric for describing the complexity of different regular grammars. Based on the entropy metric, we categorized regular grammars into three disjoint subclasses: the polynomial, exponential and proportional classes. In addition, several classification theorems are provided for different representations of regular grammars. Our analysis was validated by examining the process of learning grammars with multiple recurrent neural networks. Our results show that as expected more complex grammars are generally more difficult to learn.
Adaptive Sliding Mode Neural Network Control and Flexible Vibration Suppression of a Flexible Spatial Parallel Robot
Authors: Zhang Qingyun , Zhao Xinhua , Liu Liang , Dai Tengda
Published: January 2021

With the goal of creating a flexible spatial parallel robot system in which the elastic deformation of the flexible link causes a rigid moving platform to produce small vibrations, we proposed an adaptive sliding mode control algorithm based on a neural network. To improve the calculation efficiency, the finite element method was used to discretize the flexible spatial link, and then the displacement field of the flexible spatial link was described based on floating frame of reference coordinates, and the dynamic differential equation of the flexible spatial link considering high-frequency vibrations was established through the Lagrange equation. This was combined with the dynamic equation of the rigid link and the dynamic equation considering small displacements of the rigid movable platform due to elastic deformation, and a highly nonlinear and accurate dynamic model with a rigid–flexible coupling effect was obtained. Based on the established accurate multi-body dynamics model, the driving torque with coupling effects was calculated in advance for feedforward compensation, and the adaptive sliding mode controller was used to improve the tracking performance of the system. The nonlinear error was examined to determine the performance of the neural network’s approximation of the nonlinear system. The trajectory errors of the moving platform in the X-, Y-, and Z-directions were reduced by 12.1%, 38.8%, and 50.34%, respectively. The results showed that the designed adaptive sliding mode neural network control met the control accuracy requirements, and suppressed the vibrations generated by the deformation of the flexible spatial link.
Method of Estimating Uncertainty as a Way to Evaluate Continuity Quality of Power Supply in Hospital Devices
Authors: Stawowy Marek , Rosiński Adam , Paś Jacek , Klimczak Tomasz
Published: January 2021

The article presents issues related to the determination of the continuity quality of power supply (CQoPS) for hospital electrical devices. The model describing CQoPS takes into account power redundancy. The uncertainty modeling method based on the certainty factor (CF) of the hypothesis was used to establish the single-valued CQoPS factor. CQoPS modeling takes into account multidimensional quality models and physical stages of power. The quality models take into account seven dimensions that make up CQoPS (availability, appropriate amount, power supply reliability, power quality, assurance, responsiveness, security). The model of power stages includes five of these stages (power generation, delivery to recipient, distribution by recipient, delivery to device, power-consuming device). To date, when designing hospital power systems, the applied reliability indicators revealed limitations because they do not consider all the possible factors influencing the power continuity. Estimating the supply continuity quality with the use of the uncertainty modeling proposed in this article allows for taking into account all possible factors (not just reliability factors) that may affect supply continuity. The presented modeling offers an additional advantage, namely, it allows an expanded evaluation of the hospital supply system and a description using only one indicator. This fact renders the evaluation of the supply system possible for unqualified staff. At the end of the article, some examples of calculations and simulations are presented, thus showing that the applied methods give the expected results.
Fractional-Order Control of Grid-Connected Photovoltaic System Based on Synergetic and Sliding Mode Controllers
Authors: Nicola Marcel , Nicola Claudiu-Ionel
Published: January 2021

Starting with the problem of connecting the photovoltaic (PV) system to the main grid, this article presents the control of a grid-connected PV system using fractional-order (FO) sliding mode control (SMC) and FO-synergetic controllers. The article presents the mathematical model of a PV system connected to the main grid together with the chain of intermediate elements and their control systems. To obtain a control system with superior performance, the robustness and superior performance of an SMC-type controller for the control of the udc voltage in the DC intermediate circuit are combined with the advantages provided by the flexibility of using synergetic control for the control of currents id and iq. In addition, these control techniques are suitable for the control of nonlinear systems, and it is not necessary to linearize the controlled system around a static operating point; thus, the control system achieved is robust to parametric variations and provides the required static and dynamic performance. Further, by approaching the synthesis of these controllers using the fractional calculus for integration operators and differentiation operators, this article proposes a control system based on an FO-SMC controller combined with FO-synergetic controllers. The validation of the synthesis of the proposed control system is achieved through numerical simulations performed in Matlab/Simulink and by comparing it with a benchmark for the control of a grid-connected PV system implemented in Matlab/Simulink. Superior results of the proposed control system are obtained compared to other types of control algorithms.
Analysis of Various Options for Balancing Power Systems’ Peak Load
Authors: Majchrzak Henryk , Kozioł Michał
Published: January 2021

The balancing of the power of the Polish Power System (KSE) is a key element in ensuring the safety of electric energy supplies to end users. This article presents an analysis of the power demand in power systems (PS), with emphasis on the typical power variability both in subsequent hours of the day and on particular days and in particular months each year. The methodology for calculating the costs of electric energy undelivered to the end users and the amount of these costs for KSE is presented. Different possibilities have been analyzed for balancing power systems’ peak load and assumptions have been formulated for calculating the amount of the related costs. On this basis, a comparative analysis has been made of the possibility to balance peak load using operators’ system services, trans-border connections, and various energy storage solutions. On the basis of the obtained results, optimal tools have been proposed for market-based influence from transmission and distribution system operators on energy market participants’ behaviors in order to ensure the power systems’ operating safety and continuous energy deliveries to end users.
Cladding Profilometry Analysis of Experimental Breeder Reactor-II Metallic Fuel Pins with HT9, D9, and SS316 Cladding
Authors: Paaren Kyle , Lybeck Nancy , Mo Kun , Medvedev Pavel , Porter Douglas
Published: January 2021

BISON finite element method fuel performance simulations were conducted using an existing automated process that couples the Fuels Irradiation & Physics Database (FIPD) and the Integral Fast Reactor Materials Information System database by writing input files and comparing the BISON output to post-irradiation fuel pin profilometry measurements contained within the databases. The importance of this work is to demonstrate the ability to benchmark fuel performance metallic fuel models within BISON using Experimental Breeder Reactor-II fuel pin data for a number of similar pins, while building off previous modeling efforts. Changes to the generic BISON input file include implementing pin specific axial power and flux profiles, pin specific fluences, frictional contact, and irradiation-induced volumetric swelling models for cladding. A statistical analysis of irradiation-induced volumetric swelling models for HT9, D9, and SS316 was performed for experiments X421/X421A, X441/X441A, and X486. Between these three experiments, there were 174 post-irradiation examination (PIE) profilometries used for validating the swelling models presented using a standard error of the estimate (SEE) method. Implementation of the volumetric swelling models for D9 and SS316 claddings was found to have a significant impact on the BISON profilometry simulated, where HT9 clad pins had an insignificant change due to low fluence values. BISON profilometry simulated for HT9, D9, and SS316 fuel pins agreed with PIE profilometry measurements, with assembly SEE values being 4.4 × 10−3 for X421A, 2.0 × 10−3 for X441A, and 2.8 × 10−3 for X486. D9 clad pins in X421/X421A had the highest SEE values, which is due to the BISON simulated profilometry being shifted axially. While this work accomplished its purpose to demonstrate the modeling of multiple fuel pins from the databases to help validate models, the results suggest that the continued development of metallic fuel models is necessary for qualifying new metallic fuel systems to better capture some physical performance phenomena, such as the hot pressing of U-Pu-Zr and the fuel cladding chemical interaction.
A Novel Data-Driven Modeling and Control Design Method for Autonomous Vehicles
Authors: Fényes Dániel , Németh Balázs , Gáspár Péter
Published: January 2021

This paper presents a novel modeling method for the control design of autonomous vehicle systems. The goal of the method is to provide a control-oriented model in a predefined Linear Parameter Varying (LPV) structure. The scheduling variables of the LPV model through machine-learning-based methods using a big dataset are selected. Moreover, the LPV model parameters through an optimization algorithm are computed, with which accurate fitting on the dataset is achieved. The proposed method is illustrated on the nonlinear modeling of the lateral vehicle dynamics. The resulting LPV-based vehicle model is used for the control design of path following functionality of autonomous vehicles. The effectiveness of the modeling and control design methods through comprehensive simulation examples based on a high-fidelity simulation software are illustrated.
Generational Effects of Opioid Exposure
Authors: Odegaard Katherine E. , Pendyala Gurudutt , Yelamanchili Sowmya V.
Published: January 2021

The inheritance of substance abuse, including opioid abuse, may be influenced by genetic and non-genetic factors related to the environment, such as stress and socioeconomic status. These non-genetic influences on the heritability of a trait can be attributed to epigenetics. Epigenetic inheritance can result from modifications passed down from the mother, father, or both, resulting in either maternal, paternal, or parental epigenetic inheritance, respectively. These epigenetic modifications can be passed to the offspring to result in multigenerational, intergenerational, or transgenerational inheritance. Human and animal models of opioid exposure have shown generational effects that result in molecular, developmental, and behavioral alterations in future generations.
The Importance of High–Quality Data for REDD+ Monitoring and Reporting
Authors: Sandker Marieke , Carrillo Oswaldo , Leng Chivin , Lee Donna , d’Annunzio Rémi , Fox Julian
Published: January 2021

This article discusses the importance of quality deforestation area estimates for reliable and credible REDD+ monitoring and reporting. It discusses how countries can make use of global spatial tree cover change assessments, but how considerable additional efforts are required to translate these into national deforestation estimates. The article illustrates the relevance of countries’ continued efforts on improving data quality for REDD+ monitoring by looking at Mexico, Cambodia, and Ghana. The experience in these countries show differences between deforestation areas assessed directly from maps and improved sample-based deforestation area estimates, highlighting significant changes in both magnitude and trend of assessed deforestation from both methods. Forests play an important role in achieving the goals of the Paris Agreement, and therefore the ability of countries to accurately measure greenhouse gases from forests is critical. Continued efforts by countries are needed to produce credible and reliable data. Supporting countries to continually increase the quality of deforestation area estimates will also support more efficient allocation of finance that rewards REDD+ results-based payments.
What Makes a UI Simple? Difficulty and Complexity in Tasks Engaging Visual-Spatial Working Memory
Authors: Bakaev Maxim , Razumnikova Olga
Published: January 2021

Tasks that imply engagement of visual-spatial working memory (VSWM) are common in interaction with two-dimensional graphical user interfaces. In our paper, we consider two groups of factors as predictors of user performance in such tasks: (1) the metrics based on compression algorithms (RLE and Deflate) plus the Hick’s law, which are known to be characteristic of visual complexity, and (2) metrics based on Gestalt groping principle of proximity, operationalized as von Neumann and Moore range 1 neighborhoods from the cellular automata theory. We involved 88 subjects who performed about 5000 VSWM-engaging tasks and 78 participants who assessed the complexity of the tasks’ configurations. We found that the Gestalt-based predictors had a notable advantage over the visual complexity-based ones, as the memorized chunks best corresponded to von Neumann neighborhood groping. The latter was further used in the formulation of index of difficulty and throughput for VSWM-engaging tasks, which we proposed by analogy with the infamous Fitts’ law. In our experimental study, throughput amounted to 3.75 bit/s, and we believe that it can be utilized for comparing and assessing UI designs.
Acknowledgment to Reviewers of Fluids in 2020
Authors:   Fluids Editorial Office
Published: January 2021

Peer review is the driving force of journal development, and reviewers are gatekeepers who ensure that Fluids maintains its standards for the high quality of its published papers [...]
Determination of Post-Harvest Biochemical Composition, Enzymatic Activities, and Oxidative Browning in 14 Apple Cultivars
Authors: Serra Sara , Anthony Brendon , Boscolo Sesillo Francesca , Masia Andrea , Musacchi Stefano
Published: January 2021

Phenolic compounds in fruit provide human health benefits, and they contribute to color, taste, and the preservation of post-harvest fruit quality. Phenolic compounds also serve as modifiers of enzymatic activity, whether inhibition or stimulation. Polyphenol oxidases (PPO) and peroxidases (POD) use phenolic compounds as substrates in oxidative browning. Apple browning leads to flesh color, taste, texture, and flavor degradation, representing a drawback for the variety and its’ market appraisal. This study was conducted to investigate the process of browning in 14 apple cultivars throughout post-harvest at three-time points: immediately (T0), one hour (T1), and 24 h (T2) after apples were cut in half. Color parameters L* (lightness), a* (red/green), b* (yellow/blue) were measured, and chroma (ΔC*) and color (ΔE) were calculated to quantify differences between T0₋T1 and T1₋T2 on the fruit surface. Enzymatic activity (PPO, POD) and phenolic composition were also quantified for each cultivar. ‘Granny Smith’ and ‘Cripps Pink’ browned minimally. In contrast, ‘Fiesta’ and ‘Mondial Gala’ browned severely, reporting high enzymatic activity and quantified phenolic concentration (QPC). Phenolic compound polymerization appears to play a significant role in enzymatic inhibition. ‘Topaz’ does not fit the high QPC, PPO, and browning formula, suggesting alternative pathways that contribute to apple browning.
Suprabasin—A Review
Authors: Pribyl Miroslav , Hodny Zdenek , Kubikova Iva
Published: January 2021

Among the ~22,000 human genes, very few remain that have unknown functions. One such example is suprabasin (SBSN). Originally described as a component of the cornified envelope, the function of stratified epithelia-expressed SBSN is unknown. Both the lack of knowledge about the gene role under physiological conditions and the emerging link of SBSN to various human diseases, including cancer, attract research interest. The association of SBSN expression with poor prognosis of patients suffering from oesophageal carcinoma, glioblastoma multiforme, and myelodysplastic syndromes suggests that SBSN may play a role in human tumourigenesis. Three SBSN isoforms code for the secreted proteins with putative function as signalling molecules, yet with poorly described effects. In this first review about SBSN, we summarised the current knowledge accumulated since its original description, and we discuss the potential mechanisms and roles of SBSN in both physiology and pathology.
Bridging the Gap between Vertebrate Cytogenetics and Genomics with Single-Chromosome Sequencing (ChromSeq)
Authors: Iannucci Alessio , Makunin Alexey I. , Lisachov Artem P. , Ciofi Claudio , Stanyon Roscoe , Svartman Marta , Trifonov Vladimir A.
Published: January 2021

The study of vertebrate genome evolution is currently facing a revolution, brought about by next generation sequencing technologies that allow researchers to produce nearly complete and error-free genome assemblies. Novel approaches however do not always provide a direct link with information on vertebrate genome evolution gained from cytogenetic approaches. It is useful to preserve and link cytogenetic data with novel genomic discoveries. Sequencing of DNA from single isolated chromosomes (ChromSeq) is an elegant approach to determine the chromosome content and assign genome assemblies to chromosomes, thus bridging the gap between cytogenetics and genomics. The aim of this paper is to describe how ChromSeq can support the study of vertebrate genome evolution and how it can help link cytogenetic and genomic data. We show key examples of ChromSeq application in the refinement of vertebrate genome assemblies and in the study of vertebrate chromosome and karyotype evolution. We also provide a general overview of the approach and a concrete example of genome refinement using this method in the species Anolis carolinensis.
Non-Pathological Opacification of the Cavernous Sinus on Brain CT Angiography: Comparison with Flow-Related Signal Intensity on Time-of-Flight MR Angiography
Authors: Heo Sun Ah , Kim Eun Soo , Lee Yul , Lee Sang Min , Lee Kwanseop , Yoon Dae Young , Ju Young-Su , Kwon Mi Jung
Published: January 2021

Purpose: To investigate the non-pathological opacification of the cavernous sinus (CS) on brain computed tomography angiography (CTA) and compare it with flow-related signal intensity (FRSI) on time-of-flight magnetic resonance angiography (TOF-MRA). Methods: Opacification of the CS was observed in 355 participants who underwent CTA and an additional 77 participants who underwent examination with three diagnostic modalities: CTA, TOF-MRA, and digital subtraction angiography (DSA). Opacification of the CS, superior petrosal sinus (SPS), inferior petrosal sinus (IPS), and pterygoid plexus (PP) were also analyzed using a five-point scale. The Wilcoxon test was used to determine the frequencies of the findings on each side. Additionally, the findings on CTA images were compared with those on TOF-MRA images in an additional 77 participants without dural arteriovenous fistula (DAVF) using weighted kappa (κ) statistics. Results: Neuroradiologists identified non-pathological opacification of the CS (n = 100, 28.2%) on brain CTA in 355 participants. Asymmetry of opacification in the CS was significantly correlated with the grade difference between the right and left CS, SPS, IPS, and PP (p < 0.0001 for CS, p < 0.0001 for SPS, p < 0.0001 for IPS, and p < 0.05 for PP). Asymmetry of the opacification and FRSI in the CS was observed in 77 participants (CTA: n = 21, 27.3%; TOF-MRA: n = 22, 28.6%). However, there was almost no agreement between CTA and TOF-MRA (κ = 0.10, 95% confidence interval: −0.12–0.32). Conclusion: Asymmetry of non-pathological opacification and FRSI in the CS may be seen to some extent on CTA and TOF-MRA due to anatomical variance. However, it shows minimal reliable association with the FRSI on TOF-MRA.
Examining the Suitability of the List of Indicators Describing Age-Related Typical Support Needs
Authors: Amor Antonio M. , Verdugo Miguel A. , Arias Benito , Fernández María , Aza Alba
Published: January 2021

The list of indicators is a form of training material used for the Supports Intensity Scale—Children’s version (SIS-C). It is aimed at helping interviewers distinguishing between extraordinary and age-related typical support needs in children with intellectual and developmental disabilities (IDD) when implementing the SIS-C, and thus improve supports planning. The aim of this study is to adapt and test the list of indicators’ content validity and rating scale’s functioning in Spain. A total of 222 general education teachers reported their agreement with each indicator description using a 5-point rating scale. A total of 353 of 366 indicators showed evidence of content validity, whereas analyses on the rating scale highlighted the necessity of subsuming one of the scale categories within another. The need for developing research-based training materials to develop training programs on the use of the SIS-C to support decision-making concerning supports planning with students with IDD, the relevance of using the latest methodological approaches available when required, and future lines of research are discussed.
Association between Dyslipidemia and Mercury Exposure in Adults
Authors: Kang Purum , Shin Hye Young , Kim Ka Young
Published: January 2021

Background—Dyslipidemia is one of the prominent risk factors for cardiovascular disease, which is the leading cause of death worldwide. Dyslipidemia has various causes, including metabolic capacity, genetic problems, physical inactivity, and dietary habits. This study aimed to determine the association between dyslipidemia and exposure to heavy metals in adults. Methods—Using data from the seventh Korean National Health and Nutrition Examination Survey (2016–2017), 5345 participants aged ≥20 years who were tested for heavy metal levels were analyzed in this study. Multiple logistic regression was conducted to assess the factors affecting the prevalence of dyslipidemia. Results—The risks of dyslipidemia among all and male participants with mercury (Hg) levels of ≥2.75 μg/L (corresponding to the Korean average level) were 1.273 and 1.699 times higher than in those with levels of <2.75 μg/L, respectively. The factors that significantly affected the dyslipidemia risk were age, household income, body mass index, and subjective health status in both males and females. Conclusions—In adult males, exposure to Hg at higher-than-average levels was positively associated with dyslipidemia. These results provide a basis for targeted prevention strategies for dyslipidemia using lifestyle guidelines for reducing Hg exposure and healthy behavioral interventions.
Chronic Effects of a Training Program Using a Nasal Inspiratory Restriction Device on Elite Cyclists
Authors: Gonzalez-Montesinos Jose L. , Fernandez-Santos Jorge R. , Vaz-Pardal Carmen , Aragon-Martin Ruben , Arnedillo-Muñoz Aurelio , Reina-Novo Jose , Orantes-Gonzalez Eva , Heredia-Jimenez Jose , Ponce-Gonzalez Jesus G.
Published: January 2021

This study compared the response of a 9-week cycling training on ventilatory efficiency under two conditions: (i) Combined with respiratory muscle training (RMT) using a new nasal restriction device (FeelBreathe) (FB group) and (ii) without RMT (Control group). Eighteen healthy elite cyclists were randomly separated into the FB group (n = 10) or Control group (n = 8). Gas exchange was measured breath by breath to measure ventilatory efficiency during an incremental test on a cycloergometer before (Pre) and after (Post) the nine weeks of training. The FB group showed higher peak power (Δ (95%HDI) (0.82 W/kg (0.49, 1.17)), VO2max (5.27 mL/kg/min (0.69, 10.83)) and VT1 (29.3 W (1.8, 56.7)) compared to Control at PostFINAL. The FB group showed lower values from Pre to PostPRE in minute ventilation (VE) (−21.0 L/min (−29.7, −11.5)), Breathing frequency (BF) (−5.1 breaths/min (−9.4, −0.9)), carbon dioxide output (VCO2) (−0.5 L/min (−0.7, −0.2)), respiratory equivalents for oxygen (EqO2) (−0.8 L/min (−2.4, 0.8)), heart rate (HR) (−5.9 beats/min (−9.2, −2.5)), respiratory exchange ratio (RER) (−0.1 (−0.1, −0.0) and a higher value in inspiratory time (Tin) (0.05 s (0.00, 0.10)), expiratory time (Tex) (0.11 s (0.05, 0.17)) and end-tidal partial pressure of CO2 (PETCO2) (0.3 mmHg (0.1, 0.6)). In conclusion, RMT using FB seems to be a new and easy alternative ergogenic tool which can be used at the same time as day-to-day training for performance enhancement.
Value of Immunizations during the COVID-19 Emergency
Authors: Stefanati Armando , d’Anchera Erica , De Motoli Francesco , Savio Marta , Toffoletto Maria Vittoria , Gabutti Giovanni
Published: January 2021

Recent estimates by World Health Organization (WHO, Geneva, Switzerland) and United Nations International Children’s Emergency Fund (UNICEF) show a significant decline in vaccinal coverage rates in both pediatric and adult populations. The interruption of vaccination services is reported in at least 68 countries, with the involvement of about 80 million children worldwide. The situation is alarming if we consider that already in the period preceding the pandemic, immunization programs slowed down in various areas of the world. For these reasons, there is the risk of overloading health systems, already under pressure from the pandemic emergency, by employing human and economic resources for the management of epidemic outbreaks from vaccine-preventable diseases. The restoration and integration of vaccination services, the immunization of susceptible individuals as well as the adoption of adequate monitoring and surveillance measures are the main activities adopted by different countries to address the current global health emergency.
Efficacy of Three Commercial Disinfectants in Reducing Microbial Surfaces’ Contaminations of Pharmaceuticals Hospital Facilities
Authors: Di Martino Giuseppina , Pasqua Salvatore , Douradinha Bruno , Monaco Francesco , Di Bartolo Chiara , Conaldi Pier Giulio , D’Apolito Danilo
Published: January 2021

To evaluate and validate the efficacy of disinfectants used in our cleaning procedure, in order to reduce pharmaceutical hospital surfaces’ contaminations, we tested the action of three commercial disinfectants on small representative samples of the surfaces present in our hospital cleanrooms. These samples (or coupons) were contaminated with selected microorganisms for the validation of the disinfectants. The coupons were sampled before and after disinfection and the microbial load was assessed to calculate the Log10 reduction index. Subsequently, we developed and validated a disinfection procedure on real surfaces inside the cleanrooms intentionally contaminated with microorganisms, using approximately 107–108 total colony forming units per coupon. Our results showed a bactericidal, fungicidal, and sporicidal efficacy coherent to the acceptance criteria suggested by United States Pharmacopeia 35 <1072>. The correct implementation of our cleaning and disinfection procedure, respecting stipulated concentrations and contact times, led to a reduction of at least 6 Log10 for all microorganisms used. The proposed disinfection procedure reduced the pharmaceutical hospital surfaces’ contaminations, limited the propagation of microorganisms in points adjacent to the disinfected area, and ensured high disinfection and safety levels for operators, patients, and treated surfaces.