bluuebunny/crossref_metadata_2025 huggingface dataset:
Rhabdomyosarcoma in Pediatric Patients: the Contribution of the Belarussian Research Center for Pediatric Oncology, Hematology and Immunology to the Study of Promising Molecular Genetic Characteristics of the Tumor Process
Authors: Герасимович В.Д. , Кальченко К.О. , Михалевская Т.М. , Савицкая Т.В. , Киселёв Л.П.
Published: February 2022

Поиск новых возможностей для индивидуализации терапии пациентов детского возраста с рабдомиосаркомами (РМС) представляется актуальным направлением современных научно-практических исследований. Молекулярно-генетические характеристики опухоли могут быть эффективно использованы для более точного прогнозирования клинического исхода заболевания, генетически направленной терапии, а также посттерапевтического мониторинга качества ремиссии. Такой подход может быть эффективен для селекции случаев с агрессивным поведением новообразования с целью использования максимально интенсивных терапевтических подходов, но в то же время выделить когорты пациентов, которым показано менее интенсивное (и менее токсичное) лечение без ущерба онкологической безопасности. В настоящем сообщении проведен анализ данных литературы и представлена характеристика исследований молекулярно-генетических маркеров, ассоциированных с РМС, осуществляемых в Республиканском научно-практическом центре детской онкологии, гематологии и иммунологии (Республика Беларусь).

The search for new treatment opportunities of personalized treatment among pediatric patients with rhabdomyosarcoma (RMS) is a promising area of current research and clinical practice. The tumor molecular-genetic characteristics can be effectively used for more accurate prediction of the disease outcome, genetical therapy, as well as a post-therapeutic monitoring of the remission quality. This approach can be effective for selecting cases with aggressive behavior of the neoplasm in order to use the most intensive therapeutic approaches, but at the same time identify cohorts of patients who are indicated for less intensive (and less toxic) treatment without compromising oncological safety. This report provides the literature analysis and presents the characteristics of the conducted research of molecular genetic markers associated with RMS, carried out at the Belarusian Research Center for Pediatric Oncology, Hematology and Immunology (Belarus).
Congenital Angioedema: Molecular Basis of Formation, Mechanisms of Development, Features of Clinical Manifestations, Pathogenetic Therapy
Authors: Гурьянова И.Е.
Published: February 2022

Врожденный ангионевротический отек (ВАО) - редкое генетическое заболевание, проявляющееся в виде повторяющихся отеков слизистой оболочки, поражающих любые участки тела: конечности, лицо, стенку кишечника, гортань и др. Медиатором ВАО является брадикинин, вследствие чего ВАО относится к группе брадикининопосредованных отеков. К настоящему времени найдены генетические нарушения, приводящие к формированию ВАО, расположенные не только в гене SERPING1, но и в генах FXII, PLG, ANGPT1, KNG1, MYOF и HS3ST6. Некоторые из ассоциированных с ВАО генов участвуют в метаболизме брадикинина, тогда как другие влияют на процессы регуляции проницаемости эндотелия. Целью данной работы явилось повысить осведомленность о молекулярных основах врожденного ангионевротического отека для лучшего понимания путей и процессов, вовлеченных в патогенез заболевания. Изучение патогенеза ВАО на молекулярно-генетическом уровне является чрезвычайно актуальным, подобные исследования позволяют лучше понять природу заболевания и подобрать эффективную тактику лечения пациента. В настоящее время главным пусковым механизмом приступов ВАО считается аномальная гиперактивация контактной системы активации и кининкалликреиновой системы с повышенным производством брадикинина, образующегося при расщеплении высокомолекулярного кининогена при участии прекалликреина, и не является следствием активации системы комплемента.

Hereditary angioedema (HAE) is a rare genetic disease characterized by recurrent episodes of non- pruritic edema that affects any part of the body: limbs, face, intestinal walls, larynx, etc. Genetic variants that lead to HAE have been found not only in the SERPING1 gene, but also in the FXII, PLG, ANGPT1, KNG1, MYOF, and HS3ST6 genes. Some of the HAE-associated genes are involved in the metabolism of bradykinin, while others influence various processes involved in endothelial permeability. To raise awareness of the molecular basis of hereditary angioedema for better understanding the pathways and processes involved in the pathogenesis of this disease was the main purpose of writing this article. Studying the pathogenesis of HAE at the molecular-genetic level is extremely relevant, such studies allow us to better understand the nature of the disease and choose effective tactics for treating a patient with HAE. Currently, the main trigger of vascular permeability in HAE is considered to be abnormal hyperactivation of the “contact activation system” and the kinin-kallikrein system with increased production of bradykinin, obtained by the cleavage of high molecular weight kininogen, with the participation of prekallikrein.
Intraoperative Analysis of Localization and Prevalence of Adhesions in the Abdominal Cavity
Authors: Клюйко Д.А.
Published: February 2022

Введение. Профилактика и лечение спаечной болезни брюшной полости являются актуальной проблемной современной медицины, учитывая стремительный рост количества оперативных вмешательств и увеличение продолжительности жизни пациентов. Цель. Изучить топографо-анатомические особенности и распространенность спаечного процесса у пациентов со спаечной болезнью брюшной полости и спаечной кишечной непроходимостью. Материалы и методы. С помощью перитонеального индекса адгезии (PAI) во время хирургических вмешательств на органах брюшной полости оценены локализация и распространенность спаечного процесса у 194 пациентов. Результаты. Наиболее редкими причинами кишечной непроходимости стали конгломерат петель и выраженный спаечный процесс - по 6 случаев (11,8%), а также тотальный спаечный процесс (8 случаев (15,7%)), так как петли кишечника фиксированы и лишены подвижности. Напротив, наиболее часто кишечная непроходимость развивалась при слабо (22 случая (43,1%)) и умеренно (14 (27,5%)) выраженном спаечном процессе в брюшной полости. Выводы. Фиброзно-адгезивный процесс при спаечной болезни брюшной полости наиболее часто локализовался преимущественно в нижнем этаже брюшной полости и в области послеоперационного рубца после срединной лапаротомии, что связано с особенностями скопления патологического экссудата при воспалительных заболеваниях брюшной полости.

Introduction. Prevention and treatment of abdominal adhesions are an urgent problem of modern medicine, given the rapid increase in the number of surgical interventions and an increase in the life expectancy of patients. Purpose. To study the topographic and anatomical features and prevalence of the adhesive process in patients with adhesive abdominal disease and adhesive intestinal obstruction. Materials and methods. The localization and prevalence of the adhesive process in 194 patients were evaluated using the peritoneal adhesion index (PAI) during surgical interventions on abdominal organs. Results. The rarest causes of intestinal obstruction were a conglomerate of loops and a pronounced adhesive process - in 6 cases (11.8%), as well as a total adhesive process (8 cases (15.7%)), since the intestinal loops are fixed and motionless. On the contrary, intestinal obstruction most often developed in mild (22 cases (43.1%)) and moderate (14 (27.5%)) pronounced adhesive process in the abdominal cavity. Conclusions. The fibrous-adhesive process in abdominal adhesions was most often localized mainly in the lower floor of the abdominal cavity and in the area of the postoperative scar after median laparotomy, which is associated with the features of accumulation of pathological exudate in inflammatory diseases, insufficient sanitation and drainage of the abdominal cavity.
The Role of Cytochrome P450 Genes Polymorphic Variants in the Metabolism of Xenobiotics and the Pathogenesis of Hemoblastoses
Authors: Руденкова Т.В. , Костюк С.А. , Климкович Н.Н. , Демиденко А.Н.
Published: February 2022

Генетический статус макроорганизма оказывает непосредственное влияние на процесс развития и вариант исхода как основного заболевания, так и его осложнений. Изучение роли генов-кандидатов в развитии, течении и вариантах исхода патологических процессов является перспективным направлением с точки зрения поиска объективных маркеров для персонификации профилактики, диагностики и лечения. Актуальным направлением является поиск и изучение факторов, способных оказывать влияние на фармакокинетику или фармакодинамику химиотерапевтических препаратов, что поможет прогнозировать развитие серьезных побочных эффектов у пациентов. Наиболее перспективными для изучения являются гены, контролирующие синтез ферментов, участвующих в процессах биотрансформации ксенобиотиков. Полиморфизм данных генов является одним из факторов, определяющих структуру и функции ферментов. Изучение молекулярно-генетических особенностей генов цитохрома P450 может заложить фундамент для разработки индивидуализированного подхода к профилактике и снижению частоты развития осложнений химиотерапии.

The genetic status of a macroorganism has a direct impact on the progress and the outcome of both the disease and complications. The study of genes-candidate role in the progress, course and outcomes of pathological processes is a promising direction for prevention, diagnosis and treatment personification objective markers finding. An actual direction is the search and study of factors that can influence the pharmacokinetics or pharmacodynamics of chemotherapeutic drugs, which will help predict the development of serious side effects in patients. The most promising for study are genes that control the synthesis of enzymes involved in the xenobiotics biotransformation processes. These genes polymorphism is one of the factors that determine structure and function of enzymes. The study of the cytochrome P450 genes characteristics can lay the foundation for the development of an individualized approach to prevention and reduction of the chemotherapy complications incidence.
Acute Leukemia in Children of the First Year of Life: Clinical Cases
Authors: Сачилович Д.С. , Пугачева Ж.Н. , Ярец Ю.И. , Ромашевская И.П. , Лукьяненко Е.П. , Демиденко А.Н.
Published: February 2022

В работе представлены клинические случаи собственных наблюдений за пациентами первого года жизни с острыми лейкозами. Проанализированы гематологические и иммунофенотипические, молекулярно-генетические характеристики пациентов с острыми лимфобластными лейкозами в данной возрастной группе.

The paper presents clinical cases of our own observations of patients in the first year of life with acute leukemia. Hematological and immunophenotypic, molecular-genetic characteristics of patients with acute lymphoblastic and acute myeloid leukemias in this age group were analyzed.
Faktor-Faktor Yang Mempengaruhi Interaksi Sosial Pada Anak Usia Dini: Literatur Review
Authors: Batinah Batinah , Meiranny Arum , Arisanti Atika Zahria
Published: February 2022

One form of early adolescence development is the ability to have interaction socially, social development can be affected if the kid's potential to take social roles makes children aware of the mind, feelings, and attitudes of others. the kid's high-quality or terrible self-image is encouraged if the kid is a success or not inside the affiliation. the kid's capacity to conform to the environment, acceptance of the surroundings and other high-quality reviews for the duration of social sports is a completely vital fundamental capital. Literature review aims to look at the related factors that have an effect on social interplay in early adolescence.  In writing this newsletter, the method used was a overview of literature opinions contained in the database of health journals, particularly Google student and Pubmed, selected articles primarily based on complete textual content, unfastened open get admission to, in English and in Indonesian. Writing literature through the writer's database determined 16 articles thru Google student and four articles via PubMed. After the assessment was performed, there were 8 appropriate journals. The effects acquired were factors that have an effect on the capacity of  interaction in kids, particularly: parenting, environment, gambling with friends and the usage of devices.

 

Keywords: Interaction influence factors, Social interaction ability, Early childhood.
Faktor Sosial Budaya yang Memengaruhi Kesehatan Ibu dan Anak (Studi Etnografi)
Authors: Salsabila Salsabila , Faizah Zakiyatul , Prasetyo Budi
Published: February 2022

Maternal and child health as a key indicator of community welfare is measured by Maternal Mortality Rate (MMR) and Infant Mortality Rate (IMR). The problem of maternal and child mortality is a problem that cannot be separated from the culture or behavior of the community itself. The social and cultural system in the community is an important consideration in health services that can be utilized more optimally. The purpose of this study was to determine what cultural factors affect the health of mothers and children. This research is a rapid ethnographic assessment procedure (REAP) with a qualitative approach. Sampling technique using snowball or chain referral sampling. It is carried out sequentially from one participant to another. Is a variation of the purposive sample. The number of respondents as many as 8 people who fit the inclusion criteria. The data shown were the result of indepth interviews and FGDs (Focus Group Discussion). This study resulted in findings about: (1) Kyai become community role models in responding to life's problems ranging from political choices to choices of access to health. (2) Women do not have sufficient full power or empower themselves to choose health services, especially during pregnancy and childbirth. (3) The element of belief inherited from generation to generation also forms the knowledge system of the Cibitung community. (4) The livelihood system of farm laborers as the main source of the economy in Cibitung. 

Keywords: Socio-Cultural, Ethnographic, Religious Systems, Kinship Systems, Knowledge Systems, Livelihood Systems
Tingkat Penerimaan Masyarakat terhadap Variasi Stik Berbahan Dasar Tepung Daun Katuk
Authors: Suciati Siti , Rustiana Ernik
Published: February 2022

Leaf Katuk sticks are sticks made from wheat flour with the addition of katuk leaf flour. Moringa leaves contain polyphenols and steroids that can increase prolactin levels which play a role in producing breast milk. The purpose of this study was to determine the level of public acceptance of variations of sticks made from katuk leaf flour. This type of research is observational with a pre experimental design. The sample used in this study was 30 panelists who were determined by accidental sampling who met the inclusion criteria and the panelists were asked to feel and assess the variation of sticks made from katuk leaves. Assessment based on organoleptic theory. The variations of the Katuk Leaf Sticks were tested for differences in the level of acceptance. Statistical analysis of the acceptance rate using the Kruskal Wallis testing technique with an alpha value of 0.05. Based on the results of organoleptic and hedonic testing from the panelists, it is known that there are differences in the level of acceptance of variations of sticks made from katuk leaves both in terms of aroma, taste, texture and color with Asymp values. Sig < 0.005. The results of the different acceptance rates for variations of the katuk leaf sticks are that there are differences in the acceptance rates for formula 1, formula 2, and formula 3 sticks . The most accepted variation of sticks made from katuk leaves is in Formula 1. 

 

Keywords: Acceptance Rate, Katuk Leaf Stick Variation, Organoleptic
Resistencia genética a Rhipicephalus (Boophilus) microplus en bovinos de raza criollo argentino
Authors:   , Ortega Masagué María Florencia
Published: February 2022

Rhipicephalus (Boophilus) microplus es un ectoparásito habitual de los vacunos en regiones tropicales y subtropicales de Argentina, provocando una considerable disminución en los índices de producción. Su control se realiza principalmente a través de la aplicación de acaricidas químicos; siendo el desarrollo de garrapatas resistentes a sus efectos tóxicos el mayor inconveniente asociado a su utilización. La cría de animales resistentes al parásito es un método sustentable de producción que contribuye a reducir la aplicación de biocidas. El bovino Criollo Argentino representa una población que ha sufrido un proceso de selección natural durante muchos años, obteniéndose una raza capaz de producir en ambientes desfavorables. El objetivo de este trabajo fue identificar variaciones fenotípicas individuales en las cargas de R. (B.) microplus en bovinos Criollo Argentino y detectar regiones cromosómicas asociadas utilizando microarrays de mediana y alta densidad. Datos de conteo de garrapatas fueron obtenidos luego de infestaciones artificiales sucesivas en 231 animales. Se tomaron muestras de sangre para extraer ADN y se genotipificaron 192 animales utilizando los microarrays de Affymetrix (Bos 1 y ArBos). Luego del control de calidad, y para un total de 4227 animales incluidos en el pedigrí, se obtuvieron 48210 polimorfismos de un solo nucleótido comunes a ambos microarrays que fueron utilizados para el análisis. De manera exploratoria, se reconocieron regiones cromosómicas que contienen loci de rasgos cuantitativos en los cromosomas 27, 11, 10, 9, 16, 13, 3, 19, 8 y 18. Los resultados obtenidos permiten clasificar a la raza como de resistencia elevada a la carga de R. (B.) microplus, siendo una alternativa atractiva para el desarrollo de la ganadería en las regiones endémicas para el mencionado ectoparásito. Futuros estudios de variación genética y expresión génica de genes candidatos presentes en las regiones detectadas permitirán el desarrollo de bioindicadores de resistencia a la infestación.
Clinical experience of applying a modified FILaC procedure for treatment of complex anal fistulas
Authors: Kovalev Sergey , Alibekov Albert , Orekhov Aleksei , Golovina Anastasiya , Kislov Vladimir , Voronova Olga , Mykhaylichenko Vyacheslav , Parshin Dmitry
Published: February 2022

Surgical treatment of complicated anal fistulas remains one of the most difficult issues of coloproctology. In this study we used a modification of Fistula Laser Closure procedure in complex treatment of patients with anal fistulas. The purpose of our study was to assess the short-term and remote results of applying the modified FiLaC procedure in patients with complex anal fistulas and compare these results with conventional fistulectomy. The patients with complex transsphincteric and extrasphincteric anal fistulas were prospectively divided into FiLaC and conventional fistulectomy groups. The operative duration was longer, by 31% (p<0.05), in the FiLaC group compared to the control group. The healing of fistulas was faster by 42% (p<0.05)in the FiLaC group (7.3 ± 0.5 weeks versus 12.6 ± 0.7 weeks). The Wexner Incontinence scale scores were significantly lower (p<0.05) in the FiLaC group. The recurrence of rectal fistula after the surgery was observed in 37.2% in the control group versus 17.5% in the FiLaC group (p<0.05) (median follow up period — 13 months). The pressure parameters of the anal sphincter were significantly higher (p<0.05) in the longterm follow-up period in patients of the FiLaC group and continence was maintained in 92.5% of the FiLaC group. Thus, the study has shown that the modified FiLaC procedure accelerates the healing time of the fistula by 42% (p<0.05), reduces the number of fistula recurrences from 37.2% to 17.5% (p<0.05), and has minimal negative effects on anal continence.
VIVÊNCIAS DE PRAZER E SOFRIMENTO NO TRABALHO EM PROFESSORES DE KARATE
Authors: Camilo Juliana , Rubio Katia
Published: February 2022

Este estudo investiga as vivências de prazer e sofrimento com o trabalho de professores de Karate em uma cidade metropolitana do estado de São Paulo. Para isso, como aporte epistemológico, empregamos a psicodinâmica do trabalho. Foram feitas sete entrevistas individuais com os professores, no ano de 2019. Os resultados indicaram a invisibilidade do trabalho desses educadores, laços extremamente frágeis contratuais, condições precárias estruturais para que as aulas fossem ministradas, alta demanda dos alunos quanto as competências dos professores e alta expectativa dos alunos e seus cuidadores quanto aos princípios disseminados nas aulas. Ressalta-se as estratégias defensivas que, por respeito a hierarquia e disciplina do Karate, além do receio de perder os postos de trabalho (equivalente ao desemprego), submetem-se as organizações com o mínimo de questionamento, aceitando condições precárias laborais. As vivências de prazer são maximizadas, ao se atuar com alunos de projetos sociais, assim como pela possibilidade de auxiliá-los com outros referenciais para além dos problemas sociais por eles vivenciados.
POLÍTICA DE COTAS RACIAIS NAS UNIVERSIDADES PÚBLICAS DO BRASIL DUAS DÉCADAS DEPOIS
Authors: Guimarães Eder D’Artagnan Ferreira , Zelaya Marisa
Published: February 2022

A política de cotas raciais foi adotada nas primeiras universidades públicas do Brasil em 2002 e sancionada como política governamental dez anos depois, fundamentada em um amplo processo de discussão envolvendo organizações do governo e da sociedade civil. Quase duas décadas após as primeiras iniciativas, implementadas em meio a polêmicas, disputas e reações contrárias, é possível analisar os impactos desta política, considerando informações históricas, pautas defendidas por movimentos da população preta e parda, dados empíricos das universidades e reflexões posteriores acerca das opções políticas que originaram esta ação afirmativa. A retomada histórica aprofunda as raízes das situações de vulnerabilidade social que vitima a maioria da população negra hoje e analisa criticamente a escravidão no país e as lacunas no suporte governamental aos escravos e seus descendentes. Informações do Censo Demográfico e da Pesquisa Nacional por Amostra de Domicílios (PNAD) evidenciam os números e a cor da desigualdade racial hoje, reconhecendo negros e pobres praticamente como sinônimos. E dados sobre a política de cotas possibilitam constatar o aumento significativo no acesso de estudantes pretos e pardos ao ensino superior; a manutenção da qualidade acadêmica, com a presença dos cotistas; a ampliação das oportunidades de escolarização e inserção social da população negra e pobre; e maior representatividade da sociedade brasileira nas universidades públicas. Por fim, se situa esta ação afirmativa no contexto mais amplo das opções políticas necessárias ao processo de aperfeiçoamento da democracia no Brasil.
PÓS-DIPLOMA
Authors: Ribeiro Letícia de Fátima Assis , Mota Jefferson Lucas Felix , Coelho Junior Leconte de Lisle
Published: February 2022

Com a facilidade de inserção no Ensino Superior, foi corroborado o aumento da quantidade de profissionais formados para o Mercado de Trabalho. O presente trabalho tem como objetivo identificar quais fatores levaram esses profissionais a buscarem outras profissões diferentes de suas formações. Foi realizado um estudo através de questionário online, participaram da pesquisa 56 pessoas, sendo 64,3% do sexo feminino e 35,7% do sexo masculino com média de idade de 31 anos, que possuem formação de nível superior, porém não exercem sua profissão de formação. Os resultados obtidos propagam que fatores como competividade, desemprego, falta de oportunidades, falta de experiência e necessidade de remuneração são os principais obstáculos encontrados na não atuação em sua área de formação, além de um grande aumento de profissionais qualificados atuantes na área de telemarketing. Concluiu-se que as dificuldades enfrentadas fazem com que busquem por soluções alternativas afim de inserção no Mercado de Trabalho.
EXPERIÊNCIAS DE FORMAÇÃO
Authors: Santos Junior Francisco Joatan Freitas , Pinheiro Francisco Felipe de Aguiar , Veras Kleyane Morais Veras , Farias Isabel Maria Sabino de Farias
Published: February 2022

Este artigo trata do Desenvolvimento Profissional Docente em relação às experiências dos professores supervisores no Programa Institucional de Bolsas de Iniciação à Docência (PIBID) no Ceará. O objetivo do trabalho é identificar aspectos da experiência formativa do PIBID que contribuem para o Desenvolvimento Profissional Docente da Educação Básica do Ceará. É uma pesquisa exploratória de natureza qualitativa e interdisciplinar com aportes teórico-metodológicos dos campos da história e da educação na modalidade hermenêutico-dialética. Os dados foram levantados por meio do procedimento de entrevista semiestruturada e examinados com base no processo da categorização temática. Os relatos reforçam o PIBID como importante política pública fomentadora do Desenvolvimento Profissional Docente, como uma ação político-pedagógica que possibilita aos professores desenvolver suas capacidades profissionais e intelectuais, bem como a realização pessoal no âmbito da profissão.
VIOLÊNCIA SIMBÓLICA DE GÊNERO
Authors: Maia Eloiza Helena Gonçalves
Published: February 2022

A presente pesquisa está inserida na Linha II: Processos Formativos em Educação Tecnológica, do Programa de Pós-Graduação em Educação Tecnológica (PPGET) do Centro Federal de Educação Tecnológica de Minas Gerais (CEFET-MG). Os estudos dessa linha focalizam questões da área trabalho-educação nos contextos socioeconômico e político-cultural, destacando os processos históricos e culturais, as relações entre as mudanças societárias, a educação profissional formal e não formal e o mundo do trabalho. A partir dos aportes teóricos sobre a Divisão Sexual do Trabalho (HIRATA; KERGOAT, 2002) e da Violência Simbólica (BOURDIEU, 1975, 2002, 2011), a pesquisa problematiza a violência simbólica de gênero, aqui caracterizada por assédio moral e sexual no meio acadêmico, em uma instituição federal de educação profissional e tecnológica. Buscou-se compreender como a violência simbólica de gênero se manifesta nesse contexto educacional. Foi realizado um levantamento bibliográfico acerca das temáticas discutidas em livros, bases de teses, dissertações e artigos indexados. Em seguida, foram realizadas entrevistas semiestruturadas, por meio remoto, com alunas da Educação Profissional e Tecnológica- EPT (atuais e/ou egressas), maiores de 18 anos, que vivenciaram esse tipo de violência, além da realização de entrevistas com coordenadores de curso dos diversos níveis envolvidos (Técnico, Graduação e Pós-Graduação). Após a coleta dos dados foi realizada uma exegese dos excertos de falas dos/as entrevistados/as, confrontando-os com os referenciais teóricos estudados, de forma a se inter-relacionar empiria e teoria. Como resultados, destacam-se algumas formas de violências que foram relatadas, entre elas: piadinhas e brincadeiras de mal gosto, referindo-se à falta de capacidade feminina para realizar práticas em laboratórios. Falas sugerindo “aqui não é lugar de mulher”. Discriminação em relação ao “cabelo”, como fora do modelo “padrão” imposto pela sociedade como “belo”, entre outras. Espera-se que a pesquisa possa levar ao debate e à reflexão, dentro e fora das instituições federais de educação tecnológica, e auferir mudanças nas visões de mundo e comportamentos de todos os atores envolvidos nessas tramas sociais, propiciando avanços na igualdade de gêneros nesse segmento educacional.
The concept of active longevity as a tool for ensuring the economic security of territories in the context of population aging
Authors: Lavrikova Yu. G. , Vasil’eva E. V.
Published: February 2022

Aim. The presented study aims to analyze the possibility of applying the concept of active longevity as a response to demographic threats to the economic security of territories.

Tasks. The authors determine the theoretical and methodological prerequisites for the development of positive response measures regarding population aging based on the concept of active longevity to ensure the economic security of territories.

Methods. This study uses the methods of analysis, grouping, and systematization. To substantiate the instrument of ensuring economic security in the context of population aging, the authors propose to make allowance for state interests in the economic sphere and the interests of elderly citizens.

Results. Opportunities for applying the concept of active longevity to substantiate policies in  the field of the economic security of territories are identified.

Conclusion. The integration of the concept of active longevity into the political basis of ensuring the economic security of territories will make it possible to balance state interests in the economic sphere and the interests of elderly citizens in the context of population aging.
Russian tourism industry: consequences of the COVID-19 pandemic
Authors: Narbut V. V.
Published: February 2022

Aim. The presented study aims to statistically assess the scale of the pandemic’s negative impact on the major indicators of the tourism industry in the Russian Federation.

Tasks.The author shows the dynamics of the key indicators of the tourism industry before and during the pandemic; assesses the impact of the crisis on the activities of travel agencies; compares the amount of funds received from the sale of tourist products in Russian regions before and during the pandemic; assesses the statistical significance of changes in funds received from the sale of tourist products per company before and during the pandemic in the federal districts of Russiа.

Methods. This study presents and analyzes data of the Federal State Statistics Service on the major activity indicators of organizations in the Russian travel industry from 2017 to 2020. The data mart of the Federal State Statistics Service serves as a source of information about the activities of travel agencies in the constituent entities of the Russian Federation. In the course of the study, the author uses the methods of grouping, variation, structural and dynamic data analysis. To obtain region-specific information, a corresponding analysis was performed in 2019–2020 in 85 constituent entities of the Russian Federation. A hypothesis about data distribution normality is tested using the Shapiro–Wilk test. A hypothesis about the significance of the differences in tourist activity indicators before and during the pandemic is tested using the non-parametric Wilcoxon test, since the nature of data distribution is different from normal.

Results.It is found that the pandemic-related crisis has had a negative impact on all key indicators of the tourism industry. There have been significant job cuts, and the seasonality that is typical of the ‘healthy’ stage of the tourism industry’s development has been interrupted. The biggest decline in the number of employees is observed in the summer months of 2020. The impact of the crisis on average wages is manifested in a significant decline in April 2020 and fluctuations in the level of yearly average wages becoming more pronounced during the crisis. Quarantine measures contributed to the withdrawal of 227 companies from the Russian tourist services market, a 3.7-fold decrease in the number of tourist trips, and a 54.4% reduction in funds received from the sale of tourist products. The study presents the results of estimating the statistical significance of changes in the amount of funds received from the sale of tourist products per company before and during the pandemic in the federal districts of Russia.

Conclusions.The impact of the pandemic is expressed in the breakdown of tourism development trends that preceded it, creating prerequisites for the restructuring of the industry and the emergence of new trends. A set of measures and joint actions of the state and tourism enterprises are needed to overcome the consequences of the pandemic in the tourism sector.
Transformation of the instruments of government regulation of the economy: from non-interference to strategic managementt
Authors: Volkova E. Yu.
Published: February 2022

Aim. The presented study aims to investigate the evolution of interpretations of the government's role in the economy and to identify and describe the modern functions of the government in the economy and the corresponding regulatory instruments.

Tasks. The authors theoretically analyze the approaches of major economic schools to the interpretation of the government's role in the economy in different periods; identify historical patterns in the transformation of government functions depending on external conditions; describe economic problems in the modern world; determine government functions and effective instruments for their implementation in the current context.

Methods. This study uses general and special methods, such as induction and deduction, analysis and synthesis, generalization, systematization, comparative analysis, and content analysis. The methodological basis of the study includes the works of economists of various historical eras representing major economic schools, as well as modern research on the history of economic thought and government regulation.

Results. The approaches of leading economic schools to substantiating the adequate degree of government intervention in the economy are analyzed – from the pre-scientific period to modern Nobel laureates. The historical and economic features of different eras are established, and the most effective instruments of government regulation of the economy are indicated for each era. Based on global development trends, the main economic features and problems of the XXI century are highlighted, which are universal in the context of globalization. The transformation of government functions in the modern economy is substantiated. The authors propose an original approach to the classification of government functions depending on their focus on solving specific problems and identify instruments for implementing new functions.

Conclusions. The study highlights universal government functions in any society, such as producing public goods, protecting law and order, and updating legislation. The scope of government intervention in the economy and the selection of regulatory instruments are justified differently in the concepts of economic schools, depending on the characteristics of the external environment. During the development of human society, the degree of government influence on the economy changes. As social relations and technology become more advanced, government functions in the economy become more complex and new goals and forms of regulation appear. Government functions in the modern economy can be divided into four categories: ensuring economic development, facilitating technological progress, maintaining human capital, and economic globalization. The focus is shifting towards instruments for strategic planning, forecasting, and management and a program-oriented approach to the implementation of government functions.
Developing Mathematical Models and Methodologies to Overcome Lean Strategy Selection and Leanness Assessment Problems
Authors:   Research Scholar, Department of Mechanical Engineering, KoneruLakshmaiah Education Foundation, Vaddeswaram, Andhra Pradesh, 522502, India., DESHPANDE RAKHI ASHOK , CHALAPATHI DR. P. VENKATA ,   Professor, Department of Mechanical Engineering, KoneruLakshmaiah Education Foundation, Vaddeswaram, Andhra Pradesh, 522502, India.
Published: February 2022

This investigation inspects the impact of lean strategies among chose manufacturing organizations. In orderto remain focused; creating cheaper products at a quicker rate Lean Manufacturing would encourage the business. In this paper we discuss about adopting lean strategies by manufacturing industries with the intention of eliminating wastes. Here we create mathematical models and a systematic methodology for choosing fitting lean strategies. The main objectives of this paper are to assess the leanness levels in manufacturing organizations. In the work we will evaluate both quantitative and subjective info factors. Different tools like MATLAB, Microsoft Access and Excel, Visual Basic, DST tool will be used for developing mathematical models and methodologies to overcome lean strategy selection and leanness assessment problems. As a result we try to limit the conceivable disarray of executing different lean strategies which can be utilized by any manufacturer for surveying leanness and distinguishing their leanness benchmark Accordingly, we suggest that manufacturing firms nearby different types of organizations (benefit firms comprehensive) ought to receive lean reasoning, introduction or culture to dispense with wasteful practices in this way clearing a path for best practices that can attract main concern for the organizations.
The Design of Cavity Resonators and Microwave Filters Applying Shape Deformation Techniques
Authors: Baranowski Michal , Balewski Łukasz , Lamecki Adam , Mrozowski Michal , Galdeano Jaione
Published: February 2022

This paper introduces shape deformation as a new approach to the computer-aided design (CAD) of high frequency components. We show that geometry deformation opens up new design possibilities and offers additional degrees of freedom in the 3D modeling of microwave structures. Such design flexibility is highly desirable if the full potential of Additive Manufacturing (AM) is to be exploited in the fabrication of RF & microwave devices. The use of deformation techniques in the design of high-frequency components allows the attainment of improved electrical parameters, such as high-quality factors for cavity resonators and wide higher-order mode separation. In this work, shape deformation with radial basis functions (RBFs) is integrated with an electromagnetic field simulator based on the 3D finite-element method (FEM), allowing the semiautomated optimization of microwave components, such as cavity resonators and filters. The proposed strategy is used for the design of high Q-factor cavity resonators, cavity bandpass filters with improved spurious mode separation and of a compact twisted waveguide filter. Three designs of waveguide cavity filters with complex geometry are experimentally verified using 3D-printed prototypes fabricated with the selective laser melting (SLM) technology.
Migrazioni e politiche migratorie: uno sguardo europeo
Authors: Ambrosini Maurizio
Published: February 2022

In the coming years the European Union will be called to make challenging choices on three aspects of migration policies. The first is that of entry conditions, with particular reference to labour immigration.The second theme concerns the integration of immigrants already present on EU territory. The European Union will have to resolve issues such as greater harmonisation of criteria for naturalisation and access to local voting, especially with regard to second generations of immigrant origin.The third major arena for discussion concerns the issue of asylum and involves internal EU solidarity.
L’eterno confine. L’evoluzione della politica italiana in materia di protezione internazionale e accoglienza sul territorio a seguito della «crisi dei rifugiati» del 2015
Authors: Acocella Ivana
Published: February 2022

The purpose of the article is to investigate the progressive evolution of the Italian policy on international protection and reception system. Following the «refugee crisis» of 2015, various strategies have been tested to «reconfigure» the border and control human mobility, confusing and overlapping the inviolable obligation to protect the right of asylum with security measures aimed at safeguarding public order. The «new mobility control regime» has extended beyond the borders of national states in terms of containment and filtration devices for arriving migrants in search of protection (such as the hotspot approach and border control externalization processes).
Sistem Keamanan Smart Door Lock Menggunakan E-KTP (Elektroknik Kartu Tanda Penduduk) Berbasis Internet of Things (IoT)
Authors: Salim Djayus Nor , Pujisusilo Neira Anjar , Manik Samuel Pratama
Published: February 2022

Pintu merupakan sebuah media yang digunakan sebagai jalan untuk masuk atau keluar dari ruangan. Untuk mempermudah suatu pekerjaan dibutuhkan suatu alat yang efektif dan efisien. Tujuan dari penelitian ini adalah membuat sebuah sistem keamanan smart door lock menggunakan e-KTP berbasis Internet Of Things (IoT) dengan metode waterfall. Sistem keamanan smart door lock dibangun menggunakan RFID (Radio Frequency Identification) berbasis  IoT dengan  menggunakan  mikrokontroler  NodeMCU ESP32 dan dapat terkoneksi pada internet sehingga bisa diakses melalui smartphone android. Sistem  keamanan smart door lock ini menggunakan RFID (Radio Frequency Identification) sebagai pembukanya dan juga dengan memanfaatkan teknologi Internet Of Things (IoT) dengan menggunakan wireless yang terhubung pada aplikasi smartphone android. Berdasarkan hasil penelitian ini adalah RFID (Radio Frequency Identification) yang digunakan memiliki keamanan yang lebih terjamin, karena  yang  mana  untuk  mendaftarkan  e-KTP  dengan  menggunakan  aplikasi  Blynk pada smartphone android, jadi tidak semua orang bisa mendaftarkan e-KTP, dan juga terdapat buzzer akan mengeluarkan suara bip 1x apabila pintu dapat dibuka sesuai dengan frekuensi 13,56MHz yang terdapat dalam RFID yang dapat membaca e-KTP dengan jarak 50 mm. Buzzer akan mengeluarkan suara bip 2x apabila e-KTP tidak terdaftar pada alat  tersebut.  Solenoid  Door  Lock dapat  membuka  tuas  pintu  apabila e-KTP  tidak sesuai dengan NodeMCU ESP32, solenoid akan mengunci kembali dalam waktu 2 detik. Kesimpulan dari penelitian yang dilakukan telah dirancang dan dibangun sistem keamanan smart door lock menggunakan e-KTP berbasis Internet Of Things (IoT).
Endophytic, Non-endophytic Fungal Alkaloids and its Applications
Authors: O Archana , Nagadesi Praveen Kumar
Published: February 2022

Alkaloids are a secondary metabolite, which are extracted from a wide – array of organisms include Bacteria, Fungi, Plants and Animals. Here in present review mainly focused on the alkaloids derived from endophytic fungi and non – endophytic fungi. Fungi have provided a great source of spirit for novel drug compounds as fungi derived alkaloids have done major boon to human health and well - being. In the present review listed 35 different group of alkaloids from endophytes. In which 12 different alkaloids are kept under derivatives of Indole group, 4 different alkaloids are kept under Quinoline group, 4 different alkaloids kept under amines and amide group, from non-endophytic alkaloid 27 different group of alkaloids are reported. In which 9 different type of alkaloid are mentioned under indole group of alkaloids, 4 alkaloids are reported under diketopiperazine alkaloids, 4 different alkaloids are mentioned under ergot group of alkaloids, 3 alkaloids under prenylated indole alkaloids, 3 alkaloids are mentioned under pyridine classes. The main applications of these alkaloids are antimicrobial, Antibacterial, Antifungal, Antiviral Activity Antihelmenthic, Anticancerous, Nutrient Pedaling, Photo stimulation, Endophytes in Tissue Culture Antidiabetic Activity, and Immunosuppressive Activity; hence all the alkaloids should be used as medicines in Ayurvedam. The alkaloids derived from different fungi were reviewed and their uses in medical fields were also report.
Multifocal Diffuse Sclerosing Papillary Thyroid Carcinoma: A Rare Variant with Diagnostic Challenges
Authors: Sunny Dr. Ann Maria , S Dr. Sankar
Published: February 2022

Diffuse sclerosing papillary thyroid carcinoma (DS PTC) is a relatively rare variant of papillary thyroid carcinoma. It is characterized by distinct histological features like scattered microscopic tumor islands, diffuse sclerosis, lymphocytic infiltration, numerous psammoma bodies, radiological features like snowstorm appearance and biologically aggressive behavior in the form of invasion and metastasis. A preoperative diagnosis is often challenging in the absence of nodules and scanty fine needle aspiration cytology sample. We describe a case of multifocal diffuse sclerosing variant of papillary thyroid carcinoma in a 29 year old young male who presented with a swelling in the right side of neck of 2 month duration in the absence of a visible thyroid swelling. Neck swelling was non tender, well defined, firm, not moving with deglutition. Laboratory studies showed normal thyroid function, neck ultrasound revealed heteroechoic right lobe with multiple punctate echogenic foci and enlarged right sided cervical nodes with echogenic foci, fine needle aspiration cytology of which was consistent with metastasis from papillary adenocarcinoma. Based on the above investigations, a total thyroidectomy with central compartment lymph node dissection and modified radical neck dissection of right side was performed. Histological analysis revealed Multifocal Diffuse Sclerosing variant of papillary Thyroid Carcinoma. Clinical and histological challenges usually occur when DS PTC present as diffuse thyroid enlargement, dispersed microscopic tumor islands, extensive fibrosis, abundant lymphocytic infiltration mimicking thyroiditis and when the fine needle aspiration cytology sample is non representative.
Microbiology and Evolutionary Advances of Different Types of Pathogens in Human and Biological Conservation
Authors: Tahir Muhammad , Raza Ahmed Aniq , Iqbal Hira , Marrium Faiza , Hameed Ghazanfar , Iqbal Muhammad , Manzoor Faryal , Yasmeen Warda
Published: February 2022

Different factors involved in increasing the risk of infectious diseases caused by genetic and environmental changes. Due to high risk of infectious diseases such as chronic kidney disease, osteoarthritis, osteoporosis, Alzheimer's disease, cataracts, advances have been made in the fields of molecular sciences and engineering technology for highly effective tools and high-throughput omics technologies. Ebola virus is the most contagious as compared to the other viruses colds, influenza, or measles. Pathogenic bacteria are involved in causing of infectious diseases. Hib disease is the serious public health concern disease caused by Haemophilus influenza. Norwalk virus also causes serious abnormalities in the digestive system that ultimately leads to muscle cramp. Antimicrobial resistance have been challenging in the fields of biomedical sciences. Sequencing of bacterial genomes helpful for track the different status of fates of mutations that rise and fall through indication of multiple replicates. Genetic engineering based biomedical therapies needed to understand the target microbial cell, protein factory that secreted the variety of products.
Tropical Pulmonary Eosinophilia
Authors: Alex Nidhi Aley , S Sankar
Published: February 2022

Tropical Eosinophilia was first described in 1940 and labelled as “pseudotuberculosis with eosinophilia” [2], the term tropical pulmonary eosinophilia (TPE) was first coined by Weingarten in 1943 [3] to a syndrome of wheezing, fever, eosinophilia and bilateral mottling of the lungs. This was followed by a series of reports describing similar conditions from the tropical regions such as the Indian subcontinent [4-6]. Here we present a case of a 12 year old boy who presented with complaints of ear ache and swelling on side of neck bilaterally and on examination multiple neck nodes were palpable. On peripheral smear examination and followed by bone marrow study, Tropical eosinophilia was diagnosed.