bluuebunny/crossref_metadata_2025 huggingface dataset:
Species of the genus Vibrio of clinical– epidemiological importance
Authors: Franco Monsreal José , Serralta–Peraza Lidia Esther del Socorro , Flores Abuxapqui Javier Jesús
Published: February 2024

Vibrios are characteristically indigenous to marine, brackish, and estuarine habitats, and appear in large concentrations (blooms) when water temperatures rise (17–20°C). At low temperatures, the vibrios remain in the sediment of the seabed and the counts are usually lower than those necessary to cause infection. In temperate countries, vibrios are present in seawater throughout the year, although their concentration undergoes a notable increase in the warm months due to favorable ecological conditions and plankton, increasing their accumulation by filter feeders and other marine animals. The objective of the present study was to determine whether raw seafood, marinated without heat, partially cooked with heat, and completely cooked with heat represent potential risk factors for the species Vibrio damsela, Vibrio fluvialis and Vibrio furnissii for the development, respectively, of infection. wound; of acute gastroenteritis; and acute gastroenteritis. A list of establishments specialized in the sale of seafood for human consumption was obtained. The amount of seafood in these establishments was 390. For the homogenization and enrichment of each sample, as well as for the isolation and identification of the three species, we proceeded according to the methodology described in the eighth edition of the Bacteriological Analytical Manual (FDA). Estimation intervals at the 95% confidence level were constructed using the Cornfield method. In 32 (8.21%), 10 (2.56%) and 23 (5.90%) samples an equal number of strains were isolated whose biochemical characteristics corresponded, respectively, to Vibrio damsela, Vibrio fluvialis and Vibrio furnissii. The global prevalences obtained in raw seafood, marinated without heat, partially cooked with heat, and completely cooked with heat were, respectively, 19.46% (58/298), 0.00% (0/8), 9.09% (7/77) and 0.00% (0/7). It is concluded that raw seafood and partially cooked seafood represent potential risk factors for three of the twelve species of clinical–epidemiological importance.
Occurrence of Stomoxys calcitrans L. (Diptera: Muscidae) in cattle feces collected on pasture
Authors: Henrique Marchior Carlos
Published: February 2024

Given the above this article aims to report the occurrence of Stomoxys calcitrans (Linnaeus, 1758) in cattle dung. The experiment was carried out at the Federal University of Goiás farm in Goiânia, GO, Brazil. Every fortnight, ten dishes black plastic containers containing bovine feces were exposed for fifteen days in the pastures. After this period, the feces were sent to the laboratory for pupae extraction. The experiments were carried out from April 2006 to December 2007. A total of 628 dipterans pupae were obtained from bovine feces, from which 8 specimens of S. calcitrans emerged from 8 pupae in bovine feces collected in pastures. The percentage of individuals collected was 1.3%.
Remdesivir for COVID-19 in Hospitalized Children: A Phase 2/3 Study
Authors: Ahmed Amina , Munoz Flor M. , Muller William J. , Agwu Allison , Kimberlin David W. , Galli Luisa , Deville Jaime G. , Sue Paul K. , Mendez-Echevarria Ana , Humeniuk Rita , Guo Susan , Rodriguez Lauren , Han Dong , Hedskog Charlotte , Maxwell Heather , Palaparthy Ramesh , Kersey Kathryn , Rojo Pablo ,   CARAVAN Study Investigators
Published: February 2024

OBJECTIVES

Remdesivir decreases the risk of SARS-CoV-2 infection progressing to severe disease in adults. This study evaluated remdesivir safety and pharmacokinetics in infants and children.

METHODS

This was a phase 2/3, open-label trial in children aged 28 days to 17 years hospitalized for polymerase chain reaction–confirmed SARS-CoV-2 infection. Participants received for ≤10 days once-daily intravenous remdesivir doses defined using physiologically based pharmacokinetic modeling (for ≥40 kg, 200 mg day 1, then 100 mg/day; for age ≥28 days and ≥3 to <40 kg, 5 mg/kg day 1, then 2.5 mg/kg/day). Sparse pharmacokinetic samples were analyzed using population–pharmacokinetic approaches for remdesivir and metabolites GS-704277 and GS-441524.

RESULTS

Among 53 participants, at enrollment the median (Q1, Q3) number of days of COVID-19 symptoms was 5 (3, 7) and hospitalization was 1 (1, 3). Underlying conditions included obesity in 19 (37%), asthma in 11 (21%), and cardiac disorders in 11 (21%). Median duration of remdesivir treatment was 5 days (range, 1–10). Remdesivir treatment had no new apparent safety trends. Two participants discontinued treatment because of adverse events including elevated transaminases; both had elevated transaminases at baseline. Three deaths occurred during treatment (and 1 after). When compared with phase 3 adult data, estimated mean pediatric parameters (area under the concentration-time curve over 1 dosing interval, AUCτ, Cmax, and Cτ) were largely overlapping but modestly increased (remdesivir, 33%–129%; GS-704277, 37%–124%; GS-441524, 0%–60%). Recovery occurred for 62% of participants on day 10 and 83% at last assessment.

CONCLUSIONS

In infants and children with COVID-19, the doses of remdesivir evaluated provided drug exposure similar to adult dosing. In this study with a small sample size, no new safety concerns were observed.
Heart Failure Nurses within the Primary Care Setting
Authors: Hill Loreena , McNulty Anne , McMahon James , Mitchell Gary , Farrell Cathy , Uchmanowicz Izabella , Castiello Teresa
Published: February 2024

Cardiology services within primary care often focus on disease prevention, early identification of illness and prompt referral for diagnosis and specialist treatment. Due to advances in pharmaceuticals, implantable cardiac devices and surgical interventions, individuals with heart failure are living longer, which can place a significant strain on global healthcare resources. Heart failure nurses in a primary care setting offer a wealth of clinical knowledge and expertise across all phases of the heart failure trajectory and are able to support patients, family members and other community services, including general practitioners. This review examines the recently published evidence on the current and potential future practice of heart failure nurses within primary care.
Estimating the wage premia of refugee immigrants: Lessons from Sweden
Authors: Baum Christopher F. , Stephan Andreas ,   Linnaeus University, Faculty of Technology, Department of Forestry and Wood Technology, Zimmermann Klaus F. ,   Maastricht University, The Netherlands
Published: February 2024

This paper examines the wage earnings of fully-employed refugee immigrants in Sweden. Using administrative employer-employee data from 1990 and onwards, about 100,000 refugee immigrants who arrived between 1980 and 1996 and were granted asylum are compared to a matched sample of native-born workers. Employing recentered influence function (RIF) quantile regressions for the period 2011–2015 to wage earnings, the occupational task-based Oaxaca–Blinder decomposition approach shows that refugees perform better than natives at the median wage, controlling for individual and firm characteristics. This overperformance is due to female refugee immigrants, who have higher wages than comparable native-born female peers up to the 8th decile of the wage distribution. Refugee immigrant females perform better than native females across all occupational tasks studied, including non-routine cognitive tasks. A remarkable similarity exists in the relative wage distributions among various refugee groups, suggesting that cultural differences and the length of time spent in the host country do not significantly affect their labor market performance.
Проблеми та перспективні напрями відновлення інфраструктурно-логістичного забезпечення експорту агропродовольчої продукції в умовах воєнного стану
Authors: Смолій Л. В.
Published: February 2024

В статті досліджуються стан та тенденції функціонування інфраструктурно-логістичного забезпечення експорту агропродовольчої продукції в умовах воєнного стану в Україні. Проаналізовано масштаби втрат, зумовлених перериванням логістичних ланцюжків в сфері постачання продовольства внаслідок військової агресії. Прослідковано вплив незадовільного стану інфраструктурно-логістичного забезпечення експорту агропродовольчої продукції на національну та глобальну продовольчу безпеку. Досліджено можливості створення альтернативних шляхів експортування продукції агропродовольчого значення. Окреслено основні напрями та можливості відновлення логістичної інфраструктури із врахуванням ризиків та загроз, спричинених продовженням військових дій в Україні, зокрема, це розробка та впровадження спеціальних програм і проектів з розвитку інфраструктури, створення інноваційних технологій, що забезпечують оптимальний рівень зберігання та транспортування продукції, розширення взаємодії з міжнародними партнерами в галузі логістики та транспортування.
Method for Constructing Cadastral Maps of Flooding of River Valleys Based on Hydrodynamic and Geoinformation Modeling
Authors:   Volgograd State University, Klikunova Anna
Published: February 2024

The method of creating cadastral maps for flood areas with special conditions of use based on geoinformation and hydrodynamic modeling is described. This approach is used primarily for settlements located in river valleys. The hardware and software complex “EcoGIS-2D-Simulation” is used to conduct simulation experiments to study the dynamics of surface waters in a specific area in the vicinity of a river system. The computational module uses the Combined Smooth Particle Hydrodynamics — Total Variation Diminishing numerical algorithm for parallel integration of shallow water equations on GPUs with CUDA technology. The module for building a digital model of hydrological landscapes is an important component. This module includes a digital elevation model and sets of parameters that determine the hydrological resistance to river flow. The boundaries of the flood areas for some settlements of the Volgograd region at different values of flood probability are constructed.
Numerical Simulation of Dumping Consequences During Dredging in Coastal Marine Systems
Authors:   Don State Technical University, Sukhinov Alexander , Chistyakov Alexander ,   Don State Technical University, Sidoryakina Valentina ,   Chekhov Taganrog Institute (branch) of the Rostov State University of Economics, Kuznetsova Inna ,   Southern Federal University
Published: February 2024

The work is devoted to numerical simulation of the consequences of soil dumping in coastal marine systems. These works are associated with dredging, in which bottom sediments of various types are extracted from the bottom, and then transferred and dumped to a designated discharge site. Soil dumping works lead to the formation of areas with a high concentration of suspended matter (>50 mg/l), the sedimentation of suspended matter and the formation of an additional layer of sediment on the bottom. In the process of mathematical modeling of these processes, it is necessary to consider data on the hydrodynamic characteristics of a water body, the amount and type of soils extracted from the bottom, the redistribution of soils and the concentration of suspended matter in the aquatic environment. This paper presents mathematical models that allow taking into account the diversity of these factors. Based on them, a complex of parallel programs for high-performance computing systems has been developed that allows modeling these processes. The results of work of this complex can be used to assess risks and vulnerabilities in relation to soil dumping, as well as the implementation of environmental design in relation to a specific water body.
Numerical Study of the Influence of Changes in Electrical Conductivity on the Solution of the Direct Problem of Electrical Impedance Tomography
Authors:   Tomsk State University, Afanaseva Anna , Starchenko Alexander ,   Tomsk State University
Published: February 2024

Electrical Impedance Tomography (EIT) uses electrical stimulation and measurement at the body surface to image the electrical properties of internal tissues. It has the advantage of non-invasiveness and high temporal resolution but suffers from poor spatial resolution and sensitivity to electrode movement and contact quality. EIT can be useful to applications where there are conductive contrasts between tissues, fluids or gases, such as imaging of cancerous or ischemic tissue or functional monitoring of breathing, blood flow, gastric motility and neural activity. The work uses a complete electrode model (CEM), which is a practical model in EIT, which most realistically models electrodes. This model can simulate EIT measurements with much greater accuracy than continuum models. The mathematical formulation of the problem is written as follows: In the article [15] shows that in order for the problem to have a unique solution, the following condition must be met: Numerical studies are consistent with the conclusions from the article [14]. Useful information in the EIT is contained mainly on a small part of the boundary, i.e., on the electrodes close to the perturbations of the electrical conductivity. Boundary measurements, which are the input to the inverse conductivity problem, are more sensitive to anomalies near the boundary and to larger anomalies. This study is useful in order to know the critical values of the parameters (size, location) of a low-amplitude perturbation of conductivity, at which the measurements are insensitive and, therefore, inhomogeneities cannot be detected.
Energetics and similarity theory in the wave-affected atmospheric boundary layer
Authors:   , Keefe Oaklin R.
Published: February 2024

Here we examine the magnitude of the production and consumption terms of the turbulence kinetic energy (TKE) budget equation using observational data. This data is from two periods, each containing two months of continuous observations collected at the Woods Hole Oceanographic Institution’s (WHOI) Buzzards Bay Air-Sea Interaction Tower (BB-ASIT). BB-ASIT held a vertical co-located array of over 30 sensors spanning the ocean and the atmosphere, and twelve of those sensors are used in this analysis to examine atmospheric fluxes occurring within the wave-affected boundary layer (WBL). Using Monin-Obukhov (MO) Similarity Theory, we analyzed the fluxes and energy balance under different atmospheric stability conditions. Through a comparison of non-dimensional data with the universal functions given in Edson and Fairall (1998), we determined that the Edson and Fairall (1998)’s functions likely overestimate the shear and dissipation occurring within 5 m of the sea surface. Additionally, after quantifying the TKE production (shear production and buoyancy) and the TKE consumption (dissipation rate) we found that the production of TKE often exceeds the consumption of TKE in the WBL during high wind conditions, resulting in a dissipation deficit. We proposed wave-coherent pressure-work as another TKE consumption term that could offset this deficit, as theorized by Janssen (1999), and found that the wavecoherent pressure-work consumes a significant amount of TKE, but not enough to fully close the TKE budget equation. Future works should continue to examine how wave-coherent processes may contribute to fully closing the TKE budget equation within the WBL.
Gut microbiota at different stages of cardiovascular disease continuum
Authors: Yafarova A. A. , Dementyeva E. D. , Zlobovskaya O. A. , Kiselev A. R. , Sheptulina A. F. , Ashniev G. A. , Zhamalov L. M. , Makarov V. V. , Yudin S. M. , Drapkina O. M.
Published: February 2024

Aim. To study the relationship of gut microbiota (GM) composition with clinical and paraclinical characteristics of patients with coronary artery disease (CAD) and heart failure with reduced ejection fraction (HFrEF).

Material and methods. The study included 64 patients (men, 71,9%) with CAD, 33 (men, 87,9%) with HFrEF and 38 (men, 63,2%) with various cardiovascular risk factors (control group). GM composition was assessed using real-time polymerase chain reaction and next- generation sequencing. To identify correlations of GM composition with clinical and paraclinical characteristics, the Spearman rank correlation coefficient (ρ) was calculated. Generalized linear models (QuasiPoisson, overdispersion) with covariates (age, body mass index) were used to compare groups by phylotype.

Results. The relative abundance of Bacillota phylotypes is significantly higher in patients with CAD and HFrEF compared to controls (p<0,001). The Bacillota/Bacteroidota dysbiosis ratio was also significantly higher in patients with CAD and HFrEF than in the control group (p<0,001). According to correlation analysis, the relative representation of methanogenic archaea Methanomassiliicoccaceae, Methanomethylophilaceae (ρ=0,49, p<0,0003) directly correlated with ventricular arrhythmias in patients with HFrEF.

Conclusion. Patients with CAD and HFrEF differ significantly from the control group in GM composition at the phylotype level. In the study groups, Bacillota/Bacteroidota dysbiosis ratio was also significantly higher than in the control group. The relative abundance of the archaea Methanomassiliicoccaceae and Methanomethylophilaceae is associated with episodes of ventricular tachycardia/ventricular fibrillation.
Validation of genetic risk scores for hypertension in the Central Russian population
Authors: Limonova A. S. , Ershova A. I. , Kiseleva A. V. , Kutsenko V. A. , Ramensky V. E. , Vyatkin Yu. V. , Sotnikova E. A. , Zharikova A. A. , Zaichenoka M. , Pokrovskaya M. S. , Shalnova S. А. , Meshkov A. N. , Drapkina O. M.
Published: February 2024

Aim. To validate and evaluate the accuracy of 4 genetic risk scores (GRSs) for hypertension (HTN), previously created on European samples, on a population sample of the Ivanovo Oblast.

Material and methods. For genetic analysis, targeted next-generation sequencing was used on a sample of the Central Russia (n=1682) based on the biobank collection. Four GRSs associated with HTN, previously developed for the European population, were selected for validation. The coefficient of determination and the area under the ROC curve were used as quality metrics for regression models. Additional validation was carried out to include all nucleotide sequence variants, regardless of linkage disequilibrium level. A combined GRS was compiled based on coefficients from individual GRSs using the clumping + thresholding (C+T) method.

Results. The study demonstrated that the predictive value of previously developed GRSs when used for Central Russian population is lower than in the original studies. The proportion of explained variance was 0,5-0,8%. The best predictive ability (proportion of explained variance — 2,5%) was demonstrated using previously developed GRSs (Evangelou E, et al., 2018), which includes the largest number of nucleotide sequence variants (n=852).

Conclusion. GRSs for HTN, developed on European samples, is not recommended for Russian population without preliminary validation. To create original GRSs, combining statistical parameters (β-coefficients and p-value) from different GRS is not recommended.
Booster vaccination against the SARS-CoV-2: mechanisms and efficiency
Authors: Berns S. A. , Veremeyev A. V. , Savicheva A. A. , Gorshkov A. Yu. , Drapkina O. M.
Published: February 2024

Coronavirus disease 2019 (COVID-19) pandemic was not only a serious challenge for the healthcare system around the world, but also an incentive for intensive research and development for the introduction of innovative technologies and drugs, in particular vaccines against the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2). The first vaccination campaigns provided significant protection against severe disease course and hospitalization. However, new SARS-COV-2 variants require further comprehensive research and the introduction of booster vaccination. Booster vaccination is the most important tool for immunostimulation and increase of protection duration against the severe disease course. The study of booster vaccines, including BioNTech/Pfizer, Moderna, Oxford AstraZeneca, Sputnik V, Sinopharm и Covaxin vaccines, sheds light on their unique action mechanisms and contribution to long-term immunity. The analysis of clinical data demonstrates their effectiveness and safety. The review summarizes modern knowledge about booster vaccinations against the COVID-19 with focus on action mechanisms and efficiency. In addition, the immune system function in response to COVID-19 is considered, while the role of memory cells, antibody and cellular immunity reactions are emphasized.
In memory of Academician of the Russian Academy of Sciences Leonid S. Barbarash (06/22/1941 — 11/14/2023)
Authors: Editorial Article
Published: February 2024

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Influence of multimorbidity on the risk of events in men with chronic coronary artery disease after myocardial infarction and percutaneous coronary intervention
Authors: Dedov D. V. , Mazaev V. P. , Kovalchuk A. N. , Komkov A. A. , Ryazanova S. V.
Published: February 2024

Aim. To study the effect of multimorbidity on the risk of cardiovascular events (CVEs) in men with chronic coronary artery disease (CAD) after myocardial infarction (MI) and percutaneous coronary intervention (PCI).

Material and methods. A total of 101 men with chronic CAD after MI and PCI were included in the study (mean age 60,5±6,1 years). Of these, taking into account the non-inclusion criteria and consent to examination, 2 following groups were formed: first (n=39) — men without CVEs; 2nd (n=39) — men with CVEs. In both groups, we studied the detection rate of grade I hypertension (HTN), class I obesity, hypercholesterolemia (HCE), and type 2 diabetes (T2D). The influence of HTN, obesity, HCE, and T2D on the risk of cardiovascular events was analyzed based on the calculation of contingency tables and Pearson's χ2, as well as odds ratios (OR) with 95,0% confidence intervals (CI). The follow-up period for patients averaged 3,6±0,5 years.

Results. In men of group 2, compared with group 1 patients, grade I HTN, class I obesity, HCE were diagnosed more often in 1,3 (p=0,044), 1,4 (p=0,047), 1,2 (p=0,059) times, respectively. An increase in the risk of CVEs in men with chronic CAD, who underwent MI and PCI was associated with the detection of grade I HTN, class I obesity, HCE — OR 2,44 (CI: 1,88-6,75), OR 1,78 (CI: 1,56-4,62), OR 1,37 (CI: 1,11-4,17), respectively.

Conclusion. Thus, the detection rate of grade I HTN, class I obesity and HCE in men with chronic CAD and CVEs at long-term follow-up after MI and PCI was significantly higher compared to patients with chronic CAD without CVEs after PCI. At the same time, the detection of grade I HTN, class I obesity and HCE were associated with an increased risk of cardiovascular events.
Severity and duration of immune response in people of different age categories after SARS-CoV-2 revaccination
Authors: Drapkina O. M. , Berns S. A. , Chashchin M. G. , Gorshkov A. Yu. , Zhdanova O. V. , Ryzhakova L. N.
Published: February 2024

The article discusses the effectiveness and safety of homologous and heterologous revaccination for Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in people of different age groups.

Aim. The study the severity and duration of immune response in people of different age groups after SARS-CoV-2 revaccination.

Material and methods. The study was carried out as part of the prospective registry Saturn, which included persons who received various SARS-CoV-2 revaccination regimens (homoand heterologous) based on the combination of two vaccines: Gam-COVID-Vac and Covivac. Group I (n=106) included persons who received a homologous revaccination with Gam-COVID-Vac, while group II (n=54) — heterologous revaccination with Gam-COVID-Vac and Covivac, group III (n=40) — homologous Covivac revaccination. In addition, all participants in the study were divided into two age categories: ≥60 years (n=33) and <60 years, (n=167). In all participants, the medical history was collected. At each visit, we assessed the quantitative level of specific IgG SARS-CoV-2 S-protein antibodies and plasma coagulation using the thrombodynamics method. At visits 1, 3 and 5, blood was collected to assess T-cell immunity activity (T-Spot.COVID test, Oxford Immunotec) to the SARS-CoV-2 virus.

Results. Revaccination in persons ≥60 years of age ensures the intensity of humoral (quantitative level of specific IgG SARS-CoV-2 S-protein antibodies) and cellular immunity (quantitative assessment of SARS-CoV-2 spike protein-specific (panel A) and nucleocapsid-specific T-lymphocytes) comparable to that in younger individuals (<60 years). Revaccination did not increase the plasma thrombogenic potential in vaccinated people, regardless of age.

Conclusion. In the group of vaccinated people ≥60 years old, an adequate humoral and cellular immune response was developed, which persisted for a year after revaccination, and even more intense cellular immunity was demonstrated compared to vaccinated people <60 years old. The plasma thrombogenic potential did not increase during vaccination and revaccination, regardless of age.
Política salarial, mercados de trabalho e salários industriais no Brasil, 1960-1976: Uma análise por propriedade e tamanho da empresa
Authors: SMITH RUSSELL E.
Published: February 2024

RESUMO Este artigo analisa os papéis relativos da política salarial e das condições econômicas na determinação dos salários dos trabalhadores da produção entre 1960 e 1976 em cinco indústrias manufatureiras em São Paulo, Brasil. A análise de três subperíodos considera a direção da influência da política salarial sobre os salários reais, as mudanças observadas nos salários reais e o “desvio salarial” em relação a um índice salarial previsto com base na política salarial. Os resultados indicam que o impacto das políticas salariais repressivas durante os períodos de “apertamento salarial” de 1965-67 e 1973 variou de acordo com o tamanho da empresa e propriedade e com as condições econômicas gerais.
As velhas e as novas multinacionais: o caso da energia
Authors: NIOSI JORGE , FAUCHER PHILIPPE
Published: February 2024

RESUMO As teorias atuais sobre corporações multinacionais (MNCs) e transferência de tecnologia alcançaram vários resultados! grandes avanços. Eles são resumidos esquematicamente neste trabalho como a “síntese teórica estabelecida”, resultante da contribuição de três grandes correntes teóricas: o ciclo do produto, a organização industrial e a teoria do investimento estrangeiro direto baseado em vantagens comparativas. Este artigo desafia os pressupostos dessa síntese: segundo o autor, trata-se apenas de uma mistura conceitual crua de generalizações teóricas baseadas apenas no setor manufatureiro de multinacionais americanas e britânicas. Como alternativa, o autor compara essa síntese com evidências provenientes de um dos setores mais ativos na transferência de tecnologia Norte-Sul: a indústria de energia. A comparação permitirá esclarecer os limites do modelo teórico quando aplicado a uma indústria não manufatureira e à relação entre países desenvolvidos e em desenvolvimento.
The challenges for early intervention and its effects on the prognosis of autism spectrum disorder: a systematic review
Authors: Pires Jackson Frederico , Grattão Caroline Cajuela , Gomes Regiane Maria Ribeiro
Published: February 2024

ABSTRACT. Autism spectrum disorder (ASD) is expressed with neurobehavioral symptoms of different degrees of intensity. It is estimated that, for every three cases detected, there are two cases that reach adulthood without treatment. Objective: To establish what challenges are still present in the implementation of early intervention (EI) and its effects on the prognosis of ASD. Methods: A systematic review using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (Prisma) methodology was carried out in the PubMed and ScienceDirect databases in January 2023. The search keywords were “autism spectrum disorder”, “early intervention” and “prognosis”. Results: Sixteen studies were included, two randomized and 14 non-randomized. Knowledge about the signs of ASD, diagnostic and therapeutic methods, age at the start of treatment, and socioeconomic factors were the main challenges encountered in the implementation of the EI. Conclusion: EI is capable of modifying the prognosis of ASD and challenges in its implementation persist, especially in developing regions with low socioeconomic status.
Cognitive impairment and neuropsychiatric symptoms among individuals with history of symptomatic SARS-CoV-2 infection: a retrospective longitudinal study
Authors: Sousa Nariana Mattos Figueiredo , Maranhão Ana Claudia Paradella Freitas , Braga Lucia Willadino
Published: February 2024

ABSTRACT. COVID-19 is a multisystem disease caused by the RNA virus (coronavirus 2 or SARS-CoV-2) that can impact cognitive measures. Objective: To identify the main cognitive and neuropsychiatric symptoms in adults who had no cognitive complaints prior to the infection. Specifically, to observe the trajectory of cognitive and neuropsychiatric performance after 6 months. Methods: This is a retrospective longitudinal study. Forty-nine patients (29 reassessed after 6 months), with a positive PCR test, with no prior cognitive complaints that only presented after the infection and without a history of structural, neurodegenerative or psychiatric neurological diseases. A brief cognitive assessment battery (MoCA), the Trail Making Test (TMT-A, B, ∆), and the Verbal Fluency Test were used, as well as the scales (Hospital Anxiety and Depression Scale-HADS, Fatigue Severity Scale-FSS). Correlation tests and group comparison were used for descriptive and inferential statistics. Level of significance of α=5%. Results: Mean age of 50.4 (11.3), 12.7 (2.8) years of education, higher percentage of women (69.8%). No psycho-emotional improvement (depression and anxiety) was observed between the evaluations, and patients maintained the subjective complaint of cognitive changes. The HAD-Anxiety scale showed a significant correlation with TMT-B errors. The subgroup participating in cognitive stimulation and psychoeducation showed improvement in the global cognition measure and the executive attention test. Conclusion: Our results corroborate other studies that found that cognitive dysfunctions in post-COVID-19 patients can persist for months after disease remission, as well as psycho-emotional symptoms, even in individuals with mild infection. Future studies, with an increase in casuistry and control samples, are necessary for greater evidence of these results.
Construção e validação de História em Quadrinhos para crianças com leucemia linfoide aguda
Authors: Silva Giovani Basso da , Souza Luccas Melo de , Canabarro Simone Travi
Published: February 2024

Resumo Introdução O câncer tem impacto na vida das crianças e seus familiares. As Histórias em Quadrinhos podem ser uma estratégia de fortalecer o vínculo e a comunicação entre profissional/paciente/família. Objetivo Desenvolver e validar um material instrucional/educativo, no formato de Histórias em Quadrinhos, voltada para crianças hospitalizadas com leucemia linfóide aguda. Metodologia Estudo metodológico desenvolvido em nove etapas: elaboração do projeto de pesquisa; definição e seleção do conteúdo; adaptação da linguagem; inclusão de ilustrações; construção de um material piloto; validação do material; layout; impressão final e disponibilização. A validação ocorreu com 10 especialistas entre março e maio de 2022, utilizando-se o Instrumento de Validação de Conteúdo Educativo em Saúde. Resultados Foram elaboradas 5 Histórias em Quadrinhos, com 6 personagens principais, sendo necessárias 63 horas de trabalho. Elas foram divididas por temáticas (distúrbios gastrointestinais; cistite hemorrágica; problemas relacionados a autoestima e autoimagem; risco de infecção e dor óssea) que obtiveram Índice de Validade de Conteúdo global satisfatório entre 0,78 e 0,87. Conclusões e implicações para a prática As histórias em quadrinhos podem ser utilizadas como fonte atrativa e confiável de informações sobre a doença, servindo como apoio às informações durante a internação hospitalar e o preparo para alta.
Devir-terra na literatura de ficção visionária de Jota Mombaça
Authors: Viana Wes , Lima Ana Maria Pereira
Published: February 2024

Resumo Partimos do território contestado da literatura brasileira contemporânea (Dalcastagnè, 2012), caracterizado por um apagamento histórico de mulheres escritoras, principalmente mulheres negras, para abordar um agravante nessas discussões: a invisibilidade de escritoras trans, travestis e não binárias na contemporaneidade da literatura brasileira. Diante desse problema, o nosso objetivo é cartografar o devir-terra na literatura de ficção visionária de Jota Mombaça (2021). E, para isso, dividimos este artigo em três momentos. No primeiro, apresentamos o conceito “ficção visionária”, da escritora Walidah Imarisha (2016). No segundo, apresentamos o conceito “mundo ordenado”, da escritora Denise Ferreira da Silva (2019). E no terceiro momento, analisamos o movimento de transição à terra, da escritora Jota Mombaça, a partir de dois capítulos do livro Não vão nos matar agora (Mombaça, 2021). Essa análise está entrelaçada com o conceito de “devir”, no texto “A literatura e a vida” (Deleuze, 1997). Baseada nessas discussões, a nossa hipótese é que a literatura de ficção visionária de Jota Mombaça anuncia às minorias que virão uma revolução molecular, com vista à descolonização do mundo colonial, capitalista e neoliberal; o fim do mundo como conhecemos.
Egg quality and performance of Japanese quail supplemented with organic and inorganic selenium
Authors: TORGA Anderson de Paula , TEIXEIRA Alexandre de Oliveira , REIS Renata de Souza , MOREIRA Leonardo Marmo , SOUSA Júlio César Melo de , MORAES Monique Silva de , LACERDA Alicia Beatriz Ferreira de , LYON Juliana Pereira , ROCHA JUNIOR Carlos Magno da
Published: February 2024

ABSTRACT The objective of this study was to assess the impact of supplementing quail diets with organic selenium (Se) at various concentrations and inorganic Se on performance, egg quality, and storage time under different conditions. In the performance trial, 360 quail aged 27 weeks were included in a completely randomized design comprising six treatments: Basal Diet; 0.15, 0.30, 0.45, and 0.60 ppm of organic Se; and 0.60 ppm of inorganic Se, supplemented “on top” of the basal diet. Six replications were used, each with 10 birds per experimental unit. For the evaluation of storage time and conditions, 720 quail eggs were employed in a completely randomized design. The design featured a 6×5×2 factorial arrangement consisting of six treatments derived from the performance trial, five storage times (7, 14, 21, 28, and 35 days), and two storage forms (refrigerated and non-refrigerated). Each replication contained one egg, totaling 12 replications. Results indicated no significant effect of organic or inorganic Se supplementation in the diets on performance or egg quality. However, Se concentration increased linearly in eggs from quail fed increasing levels of this nutrient. Selenium supplementation affected storage time and egg quality under refrigerated and room-temperature conditions. In conclusion, on-top Se supplementation at concentrations ranging from 0.15 to 0.60 ppm, whether in organic or inorganic forms, does not impact quail performance. Nevertheless, it leads to increased Se deposition in eggs, contributing to the maintenance of egg quality throughout the storage period.
PRÁCTICAS PEDAGÓGICAS EN EL SIGLO XXI: PERCEPCIÓN DEL PROFESORADO
Authors: Langarica Oscar Manuel Gill , Meléndez Grijalva Perla , Domínguez Imelda Denisse Avilés , Rodríguez Yesenia Imelda González
Published: February 2024

Estudio para conocer, caracterizar y definir las prácticas pedagógicas que se identifican en docentes de primaria debido a los cambios producidos por la pandemia Covid 19, los avances tecnológicos y la presencia de modelos educativos humanistas. La investigación efectuada como fuente del presente artículo, se sustentó en el paradigma interpretativo y diseño fenomenológico, con apoyo de redes semánticas y entrevistas a 65 profesores de diversos municipios de Chihuahua, México. En los hallazgos se encontraron prácticas centradas en el logro del aprendizaje, uso de secuencias didácticas y fragmentación del conocimiento por asignatura; hay ausencia de recursos tecnológicos; se consideran los conocimientos previos de estudiantes respecto a los contenidos y ajustes para el logro académico y no para el desarrollo integral; la evaluación es formativa, centrada en lo cognitivo. Se concluye que falta un cambio en los significados y acciones del profesorado, perciben su función y sus acciones para alcanzar el aprendizaje académico, lo que se contrapone con los modelos educativos vigentes, centrados en el alumno y su desarrollo integral, evidenciando un reto para el sistema educativo que, a pesar de las reformas y capacitaciones, no ha fortalecido un sistema de conocimientos y creencias orientados a una práctica más constructivista y menos instructiva.
EVALUATION OF THE EFFECTIVENESS OF COMPLEX TREATMENT OF CHRONIC SINUSITIS IN RESIDENTS OF HIGH MOUNTAINS
Authors:   Jalal-Abad State University named after B.Osmonov, Narmatova Kaniza , Maktybaeva Damira ,   International Higher School of Medicine, Kulieva Elmira ,   Kyrgyz State Medical Academy named after I. Ahunbaeva, Zakirov Toktomat ,   Kyrgyz State Medical Academy named after I. Ahunbaeva
Published: February 2024

The purpose of this work was to study the clinical features of the course of chronic maxillary sinusitis in mountainous conditions, as well as the effect of the use of an immunomodulatory drug on the course of the disease. The effectiveness of the drug polyoxidonium was evaluated since it has not only an immunomodulatory effect, but also an antioxidant, which is very important in high altitude conditions. The study included 55 adults with chronic maxillary sinusitis: the main group consisted of 25 patients who were included in the complex therapy with polyoxidonium. The comparison group consisted of 30 people whose complex therapy did not include polyoxidonium. In the study, as criteria for assessing the effectiveness of therapy, the dynamics of symptoms of intoxication, symptoms of inflammation of the nose and sinuses, by the 3rd, 5th and 10th day of treatment, the duration of the fever period was evaluated. Comprehensive treatment of chronic maxillary sinusitis in residents of mountainous areas with the use of the drug polyoxidonium made it possible to reduce the severity of the symptoms of "Nasal discharge" and "Nasal congestion" in the early stages, to double the number of patients with no symptom of "Nasal discharge" by the 5th day therapy, it was possible to reduce the severity of the course of the infectious- inflammatory process.
THE ROLE OF THE APPLICATION OF TEXT PROBLEMS IN MATHEMATICS IN THE PRIMARY SCHOOL
Authors:   Naryn State University named after S. Naamatov, Makeev Arzymkan
Published: February 2024

This article presents the methodological foundations of the role of teaching text problems in elementary school in mathematics. Text tasks are presented as means of developing creative activity and thinking of primary school students. The process of teaching text tasks in elementary school helps to strengthen the connection between theory and practice. Thus, when elementary school students learn to solve a problem, they are given the ability to think independently and interpret the problem. At the same time, it is important to teach children to solve simple problems on their own. The article suggests ways of teaching younger students to solve problems.
WAYS TO USE EXERCISES FOR THE DEVELOPMENT OF THINKING WHEN CALCULATION OF NUMERICAL EXPRESSIONS IN THE LESSON OF MATHEMATICS IN THE PRIMARY SCHOOL
Authors:   Osh State Pedagogical University, Nadyrbekova Gulaim
Published: February 2024

The article discusses the use of exercises that develop thinking to calculate numerical expressions in a math lesson in elementary grades. The effect of performing various didactic works, interdisciplinary connections and the role of active use of exercises in the classroom are shown. Exercises were proposed for self-acquaintance of students with practical, vital issues for determining numerical expressions, finding their values using given methods, teaching computational techniques. To promote the development of communicative competence, the ability to cooperate with other people, and methods of mutual assistance are provided when working in pairs. The activity of students in solving problems, in analyzing systematization and in checking exercises is noted.
FORMATION OF SPATIAL IMAGINATIONS IN STUDENTS
Authors:   University named after Shakarim, Sagitova Shuga
Published: February 2024

It is known that the goal set by all subjects studied at school is to give students conscious knowledge and skills, and their successful mastery of the basics of knowledge is impossible without the formation of students' skills of mental work and a culture of thinking. In this regard, the formation and development of the spatial imagination of students are one of the urgent problems of the school geometry course. The article discusses the importance of the formation of the spatial imagination of students and the ways of its development. At the same time, several examples from the mathematics textbook for the 5th grade of secondary school are given in a visual form.
KIPCHAK LANGUAGE IN M. KASHGARI'S DICTIONARY "DIVAN LUGAT – AT-TURK"
Authors:   Osh State University, Tolubaeva Gulnara , Shadybekova Guljamal ,   Osh State University
Published: February 2024

This article examines the study of the Kipchak language in M. Kashgari's dictionary "Divan Lugat-atturk". It tells in detail about the languages of the Turkic tribes that have survived to this day, such as Turkic, Oguz, Uighur, Bashkir, Tatar, Kipchak, Turkmen, Kyrgyz, as well as those tribes whose names have been preserved only in history, such as Khakan, Karluk, Bechognek, Argu, Yagma, Chigil, Yabaku, tokhs, as well as the fact that the territories of these tribes are represented on a round world map. This indicates that the dictionary contains not only linguistic materials, but also information about the living conditions, customs, life, economy, legends of the Turkic tribes of that time, and how the phenomena in the Kipchak language can be spoken differently in different circumstances.
SUPPLEMENTING MODERN KYRGYZ VOCABULARY AND THAIR SEMANTICS
Authors:   Kyrgyz National University named after J. Balasagyn, Osmonova Nargul
Published: February 2024

The article discusses the issues of neologisms in the Kyrgyz language, and the prerequisites for their appearance, characteristics, role, and meaning. Everything that happens in society is reflected in the language. However, it is important to clarify whether the language changes are “instantaneous or significant”. Among the new words that appear in the language are the situation in society, changes in life on the Internet, the process, emerging videos, applications, medicine, religion, culture, and social situation. It was concluded that the task of the future is to divide these new words into sectors and epochs, to determine their load on the language, to reveal their meaning, and to divide them into groups according to features.
FORMATION OF STATE ENVIRONMENTAL POLICY IN AGRICULTURE OF SOVEREIGN KYRGYZSTAN (1991-2010)
Authors:   Osh Technological University named after M.M. Adyshev, Abduvapova Ziyagul
Published: February 2024

The sustainable socio-economic development of Kyrgyzstan is based on agriculture and the rational use of natural resources. Agriculture in Kyrgyzstan, which was in crisis during the post-Soviet transition period, caused significant damage to the environment. The purpose of the article is to study the historical aspects of the formation of state policy on environmental protection in the agricultural sector of independent Kyrgyzstan. The article examines the impact of agriculture on the environment, as well as the process of forming a regulatory framework for environmental protection in agriculture from 1991 to 2010. During the years of independence of Kyrgyzstan, as part of the implementation of the state policy on environmental protection in agriculture, a number of agroecological laws and concepts have been developed. The source base of the article was the legal acts, national concepts, and programs of the Kyrgyz Republic.
THE ORIGINS OF HOSPITALITY AS A CULTURAL PHENOMENON
Authors:   Jalal-Abad State University named after B. Osmonov, Alymkulova Gulzhan
Published: February 2024

This article explores the concept of hospitality in the worldview of the Kyrgyz people. In particular, what does hospitality mean in the traditional Kyrgyz mentality? How are hospitality practices perceived in Kyrgyz culture? And how is hospitality described in the worldview of other peoples? This article has been written to answer these questions. The main idea of the article is to tell about the features of the hospitality of the Kyrgyz people and the traditional ideas that are widespread among the people. During writing the article literature and fiction were used, as well as feature films of local ethnonational color. There also used songs about hospitality and their translation into other languages
WOMAN OF KYRGYZSTAN SCIENCE: HISTORICAL AND SOCIOLOGICAL ASPECTS
Authors:   Kyrgyz National University named after J. Balasagyn, Junushova Saykal
Published: February 2024

This article analyzes such a sociological fact as almost half of the scientists in Kyrgyzstan are women. The modern world is full of new challenges and fundamental changes in all spheres of public life, moreover, these contradictions primarily affected the position of women, regardless of their social status. Today, the need to study the phenomenon of women in these historical conditions remains relevant: family, science, culture, education, etc., and this article is generally devoted to the role of women in science in Kyrgyzstan. The gender ratios of the number of specialist researchers are analyzed, a complex characteristic of the personality of modern women scientists in Kyrgyzstan is considered and socio-psychological characteristics are given to them.
LEGISLATIVE PROVISION OF GENDER EQUALITY IN THE KYRGYZ REPUBLIC DURING THE YEARS OF INDEPENDENCE
Authors:   Osh State University, Marzabayeva Bakty , Tashibayeva Alina ,   Osh State University
Published: February 2024

The article aims at analyzing the legislative framework for ensuring gender equality in Kyrgyzstan, which has been forming in the post-Soviet period during the years of independence. The article makes a detailed analysis of the Kyrgyz Republic’s Constitution, adopted laws, ratified international conventions and National Action Plans to achieve gender equality in chronological order. It also describes their main ideas and concepts, changes that have occurred in connection with social life changes in Kyrgyzstan. The authors outline the role and contribution of NGOs and the women's movement in Kyrgyzstan to the enhancing and strengthening of the national legislation to achieve gender equality.