bluuebunny/crossref_metadata_2025 huggingface dataset:
SOME FACTORS RELATED TO THE DURATION OF INPATIENTS TREATMENT OF HERPES ZOSTER BY HE-NE LASER THERAPY AT CAN THO DERMATO-VENEREOLOGY HOSPITAL
Authors: Ha Thi Thao Mai , Pham Qui Ngoc , Huynh Van Ba , Dang Dinh Hoa Quy , Nguyen Hong Ngan , Trang Gia Vinh , Nguyen Lam Duy
Published: April 2023

Background: Shingles is caused by the Varicella-Zoster virus. The duration of hospitalization prolong will increase the risk of superinfection, costs for treatment, and quality of life. Objectives: (1) To describe clinical manifestations of herpes zoster inpatients at Can Tho Dermato-Venereology Hospital. (2) To survey some related factors related to the duration of hospitalization of herpes zoster by He-Ne laser therapy at Can Tho Dermato-Venereology Hospital. Materials and methods: the cross-sectional study on all shingles patients admitted to Can Tho Dermato-Venereology Hospital during the study period. Results: The proportion of group patients >60 years old was 54.9% higher than the group of patients ≤60 with 45.1%. Most shingles patients had secondary school degrees with 69%. The rate of patients admitted to the hospital early ≤5 days after symptom onset was 72.6%. Patients hospitalized for ≤7 days accounted for 77%. Patients with mild illness had the highest rate with 58.4%, and the rate of medium and severe illness with 36.3% and 5.3% respectively. Most patients had superinfection with 72.6%. The group of patients admitted to the hospital early ≤5 days had a shorter duration of hospitalization than the group of patients admitted to the hospital late after 5 days. In the patient's group with superinfection and more severe disease, the duration of hospitalization was longer than in the patient’s group without superinfection and the severity of the disease was milder. All differences were statistically significant, p<0.05. Conclusion: Early treatment with He-Ne laser therapy helps to improve the severity of the disease and the state of superinfection and shorten the patient's hospital stay.
A Virtual Economics Laboratory: What Generated High Inflation? 14 Different Explanations to One Inflation Period
Authors: Barak Yair
Published: April 2023

A high inflation period of seven years (1978-1985) in Israel, which turned into a hyperinflation, puzzled Israeli economists, who tried to understand its causes and mechanisms. As a result, they provided fourteen different explanations. Although all of the explanations were based on the same data, the researchers’ conclusions were either different or contradictory. This situation provides a virtual laboratory for the study of the ways and methods of economic thought; it is a classical Ceteris patribus situation. This laboratory further raises other subjects and questions. Are there principal differences between the economists' explanations? Is it possible to classify these differences? How do economic explanations for inflation differ from non-economic ones? In this article, I classified thirteen economic studies and one non-economic study into five clusters. This was the methodological tool used to inquire into the economic thought in this virtual laboratory.
Analysing the Plight of HIV-positive Women in South African Society as Represented in Sindiwe Magona’s Beauty’s Gift
Authors: Cherop Cathryne
Published: April 2023

Statistics show that South Africa has one of the highest rates of HIV/Aids in the world, with a prevalence of 18.9% of adults afflicted, and women much more vulnerable to the infection than men. Although anti-retrovirals are widely available, social injustices such as poverty and the low status of women contribute to this gendered disparity. In the novel Beauty’s Gift (2008), the author Sindiwe Magona relates a narrative in which four women lose their best friend to Aids, prompting them to take decisive action as women who play a significant role within the domain of the family. The Aids activist Jackie Achmat has called this novel “one of the most important books about HIV/AIDS in our country.” This article examines the fictional representation of the plight of HIV-positive women in South Africa through an analysis of the characterisation and the author’s representations of socio-cultural injustice suffered by these women. The paper further explores the advocacy and agency of these women characters during the time of sickness. With respect to stigma and discrimination, in the context of HIV and Aids, I argue that despair and hopelessness thrive in situations where women are plagued by sickness. I further argue that shame and secrecy are social conditions that perpetuate the spread of HIV, leading to a common response of silence. Lastly, the representations of bereavement and grief are analysed in this article. My examination of the agency of women characters in the chosen novel is underpinned by the theory of African feminism, which engages with, critiques, and develops Western feminism, influenced by African women’s resistance to Western hegemony and its legacy within African culture. Charged with the duties of transforming societies through both intellectual and pragmatic approaches, African feminists illuminate ways women manage and challenge multiple oppressions. Using this theoretical lens that reveals ways in which Magona elicits identification and empathy on the part of readers, which can assist in stimulating positive change as depicted in Beauty’s Gift, thus re-imagining and reconfiguring the Rainbow Nation.
Asociación entre los niveles de lípidos y las infecciones en las úlceras por presión en el Departamento de Salud del Hospital General de Elche
Authors: CERVERÓ FERRAGUT SALVADOR , POMARES VICENTE JAIME , RODRIGUEZ PEREZ LAURA , QUILES ANTÓN ANA , CABANILLAS MARTÍNEZ MARIA ASUNCIÓN , SANTOYO PÉREZ REMEDIOS , POMARES GUIRADO ALBERTO , SÁNCHEZ MARTÍNEZ IRENE , ROMERO VILAPLANA CONSOLACION
Published: April 2023

Introducción. Las heridas crónicas suponen un grave problema de salud con gran impacto socioeconómico debido a su morbimortalidad y a la afectación de la calidad de vida. Desde hace tiempo se conocen las propiedades de los lípidos en el sistema inmunitario. Un sistema inmunológico débil podría conducir a una infección o cronificación de las heridas. El colesterol es un lípido con importancia cuantitativa en las membranas de las células donde contribuye al mantenimiento de la fluidez de membrana. Unos niveles bajos de colesterol se relacionan con mayor riesgo de padecer infecciones. El objetivo del estudio fue analizar los niveles de lípidos en pacientes con úlceras por presión infectadas. Metodología. Se estudiaron 77 pacientes del  Departamento de Salud de Elche Hospital General con úlceras por presión infectadas en un periodo de un año. Resultados. Se ponen de manifiesto diferencias estadísticamente significativas entre pacientes con niveles de C-LDL por debajo de 70mg/dL y pacientes con niveles por encima de 70mg/dL que presentan un CT por debajo de 140mg/dL. Discusión. La investigación futura sobre estos aspectos ayudará a aclarar los mecanismos de transporte del colesterol hacia los tejidos para así protegerlos de las agresiones de los microorganismos.    
 
ABSTRACT
Introduction. Chronic wounds are a serious health problem with great socioeconomic impact due to their morbidity and mortality and the affectation of quality of life. The properties of lipids in the immune system have been known for a long time. A weak immune system could lead to infection or chronic wounds. Cholesterol is a quantitatively important lipid in cell membranes where it contributes to maintaining membrane fluidity. Low levels of cholesterol are associated with an increased risk of infections. The objective of the study was to analyze the levels of lipids in patients with pressure ulcers infected. Methodology. 77 patients with infections in pressure ulcers from the Health Department of Elche-General Hospital were studied for one year. Results. Statistically significant differences are revealed between patients with LDL-C levels below 70mg/dL and patients with levels above 70mg/dL. Levels of TC were below 140mg/dL in both groups. Discussion. Future research on these aspects will help clarify the mechanisms of cholesterol transport to the tissues and therefore protect them from microorganism aggressions.
¿Por qué mejorar la experiencia del paciente mejora los resultados en salud? Un posible modelo explicativo
Authors: Salamanca Castro Ana Belén
Published: April 2023

La evidencia disponible muestra una relación positiva entre experiencia del paciente, resultados en salud y calidad asistencial. Sin embargo, parece existir un importante salto cualitativo entre experiencia del paciente y resultados en salud. El presente artículo postula un modelo explicativo que sería capaz de explicar preguntas como: ¿por qué mejorar la experiencia del paciente funciona?, ¿cómo es posible que actuar sobre variables latentes, altamente fenomenológicos, podamos obtener mejoras objetivas? El modelo explicativo (basado en la evidencia disponible) hipotiza que pueden existir variables que actúen (como variables mediadoras unas y como variables de resultado a diferentes niveles otras) cuya interacción podría explicar los hallazgos de los estudios publicados.
Podría ser, entonces, que lo que parece ser un importante salto cualitativo no es más que el primer y el último eslabón de una cadena que involucra a diferentes variables cuyas interacciones hacen que surjan las mejoras en resultados objetivos obtenidas.
 
ABSTRACT
Evidence shows a positive relationship among patient experience, health outcomes and quality of care. However, it seems to be a high qualitative leap between patient experience and health outcomes. The current article postulates a tentative explanation model which would be able to answer questions like: why improving patient experience works? How is it possible that acting over something untouchable, highly phenomenological variables, we could get objective improvements? The explanation model (based on current evidence) postulate that there might be variables acting (as mediator variables ones and as outcome variables at different levels others) which interaction could be able to explain the results obtained in the published studies.
It could be, then, that what seems to be a high qualitative leap is just the first and the last link in a chain where several variables are involved whose interactions make possible the objective outcomes improvements obtained.
Entrepreneurial Ecosystem: Interaction between Government Policy, Funding and Networks (Study on Entrepreneurship in West Java)
Authors: Fkun Egidius , Yusuf Muhammad , Rukmana Arief Yanto , Putri Zahra Fitriana , Harahap M. Ade Kurnia
Published: April 2023

This study examines the entrepreneurial ecosystem in West Java, Indonesia, and explores the interaction between government policy, funding, and networks in shaping the ecosystem. The study uses a mixed-methods approach, including surveys and interviews with entrepreneurs and key regional stakeholders. The findings suggest that government policy, such as tax incentives and support for small and medium enterprises, is critical in creating a supportive environment for entrepreneurship in the region. Funding and networking opportunities were identified as essential components of the ecosystem. The study highlights the need for more investment-ready businesses and networking opportunities for entrepreneurs in the region. The study also identifies several challenges entrepreneurs face in the region,including limited access to funding and networking opportunities, and regulatory barriers. The study concludes that continued support for entrepreneurship in the region is necessary and suggests areas for future research, including the impact of specific government policies, cultural factors, and technology on the entrepreneurial ecosystem in West Java. Overall, this study provides valuable insights into the factors that shape the entrepreneurial ecosystem in West Java and has important implications for policymakers and stakeholders seeking to support entrepreneurship in the region.
Pengaruh Dukungan Orang Tua, Harga Diri, Pengakuan Peluang, dan Jejaring terhadap Niat Berwirausaha di Kalangan Mahasiswa Manajemen di Kota Bandung
Authors: Rukmana Arief Yanto , Bakti Rizal , Ma’sum Hadiansyah , Sholihannnisa Lulu Ulfa , Efendi
Published: April 2023

Penelitian ini bertujuan untuk mengetahui pengaruh dukungan orang tua, harga diri, pengenalan peluang, dan jejaring terhadap niat berwirausaha di kalangan manajemen mahasiswa di Kota Bandung, Indonesia. Penelitian menggunakan desain survei kuantitatif dan mengumpulkan data dari 384 peserta manajemen mahasiswa. Hasil penelitian menunjukkan bahwa pengenalan peluang dan jejaring berpengaruh positif signifikan terhadap intensi berwirausaha, sedangkan dukungan orang tua dan harga diri tidak berpengaruh signifikan. Temuan ini memiliki implikasi penting untuk mempromosikan kewirausahaan di kalangan manajemen mahasiswa di Indonesia, dengan fokus pada pengembangan pengenalan peluang dan keterampilan berjejaring.
Dampak Shock Indeks Saham Syariah Global dan Indeks Saham Syariah Regional ASEAN Terhadap Perubahan Harga Saham Pada Jakarta Islamic Index
Authors: Oceania Farradila Geta , Ardiansyah Misnen
Published: April 2023

Adanya globalisasi dan liberalisasi di pasar keuangan, investasi antar negara, dan peningkatan perusahaan multinasional dapat menghubungkan pasar di berbagai negara. Ketika terjadi satu peristiwa di suatu negara, maka negara sekitarnya akan terimbas oleh peristiwa tersebut. Penelitian ini bertujuan untuk mengetahui dan menjelaskan dampak shock yang terjadi pada indeks saham syariah global dan regional Asean terhadap perubahan harga saham di JII. Metode yang digunakan adalah Vector Error Correction Model (VECM) dengan Eviews12 untuk menganalisis hubungan jangka panjang dan jangka pendek. Populasi dalam penelitian ini adalah indeks saham syariah global dan Asean dengan Sampel Dow Jones Islamic Market China/Hongkong (DJICHK), Dow Jones Islamic Market Japan (DJIJP), Dow Jones Islamic Market US (DJIMUS), FTSE Bursa Malaysia Emas Sharia Index (FBMS), dan FTSE SFX Asia Sharia100 (SGS100). Hasil penelitian menunjukkan bahwa terdapat dua indeks pasar saham syariah yang memiliki hubungan jangka pendek yaitu DJIMUS, dan DJIJP. Sedangkan, dalam jangka panjang seluruh variabel mempengaruhi Jakarta Islamic Index (JII) Kecuali FBMS. Nilai IRF dan VD menunjukkan DJIMUS memberikan kontribusi terbesar terhadap perubahan harga saham JII. Sementara, kontribusi terkecil diberikan oleh SGS100.
Korelasi dari perkembangan Smart city Kota Bandung sebagai kota inti Metropolitan Bandung Raya terhadap kota penyangga di Kota Cimahi
Authors: Oktafrida Etric , Roychansyah Muhammad Sani
Published: April 2023

Kota Bandung sebagai kota inti metropolitan Bandung Raya telah mengembangkan berbagai infrastruktur dan teknologi untuk mendukung pengembangan smart city yang berdampak positif terhadap kota penyanggaa yang berada di sekitar. Tujuan penelitian ini adalah untuk memahami keterkaitan antara perkembangan smart city di Kota Bandung sebagai kota inti metropolitan Bandung Raya dengan perkembangan smart city di Kota Cimahi sebagai kota penyangga. Penelitian ini menggunakan pendekatan penelitian abduksi kualitatif dengan metode studi kasus. Data diperoleh melalui wawancara dengan stakeholder terkait di kedua kota dan analisis dokumen terkait dengan pengembangan smart city di kedua kota. Hasil penelitian ini dapat memberikan pemahaman yang mendalam mengenai dampak keterkaitan antara kedua kota dalam pengembangan smart city dan memberikan rekomendasi untuk meningkatkan kolaborasi dan sinergi antara kedua kota dalam pengembangan wilayah metropolitan Bandung Raya.
Penerapan Algoritma Naïve Bayes Untuk Analisis Sentimen Pengguna My JNE
Authors: Puspala Sari Regina Aswini , Jaya Irfan Dwi
Published: April 2023

Teknologi diketahui dapat mengubah gaya hidup manusia secara fundamental, salah satunya dalam aspek bisnis. Perusahaan JNE sebagai salah satu perusahaan ekspedisi tentunya menerapkan langkah untuk mengetahui bagaimana opini masyarakat terhadap pelayanan yang diberikan oleh perusahaan melalui sebuah aplikasi My JNE di google store. Hal ini bertujuan agar pihak perusahaan dapat mengetahui ulasan positif maupun ulasan negatif dari aplikasi tersebut sehingga dapat menjadi bahan pertimbangan evaluasi bagi perusahaan. Oleh karena itu penggunaan algoritma naïve bayes diperlukan dalam menganalisis sentiment positif dan negatif. Hasil klasifikasi menunjukkan kurun waktu 02 Juni 2021 sampai dengan 30 September 2021, didapatkan ulasan pengguna JNE pada website Google Play sebanyak 1.665 ulasan. Adapun pengguna paling banyak memberikan rating 1 dengan persentase 67,45% atau sebanyak 1.123 pengguna. Sedangkan pada pelabelan kelas sentimen setelah dilakukan preprocessing diketahui ulasan yang dapat diolah sebanyak 1.603 yang kemudian diperoleh jumlah ulasan negatif sebanyak 1.285 ulasan (80,16%) dan ulasan positif sebanyak 318 ulasan (19,84%).
Exploring the Influence of Teacher Qualifications, Classroom Size, Student Age, and Parental Involvement on High School Drop Out Rates in Sukabumi Regency
Authors: Permatasari Dea , Artha Bhenu
Published: April 2023

The purpose of this study was to explore the influence of teacher qualifications, classroom size, student age, and parental involvement on high school dropout rates in Sukabumi Regency. Using data from a survey of high school students in the region, multiple regression analysis was used to examine the relationships between these predictor variables and dropout rates. The results showed that all four predictor variables were significant predictors of dropout rates, with teacher qualifications and student age having the strongest influence. Specifically, having a teaching degree and license, having less than five years of teaching experience, being between the ages of 18 and 20, and larger class sizes were associated with higher dropout rates, while regular communication with teachers was associated with lower dropout rates. These findings suggest that efforts to improve teacher qualifications, reduce class sizes, and increase parental engagement and communication could help reduce high school dropout rates in Sukabumi Regency.
Peran Kecerdasan Emosional, Persepsi Stres dan Orientasi Tujuan pada Prestasi Akademik Mahasiswa di Bogor
Authors: Laratmase Antonia Junianty , Mahendika Devin , Kusuma Dewi Ratna Ayu Pawestri
Published: April 2023

Penelitian ini bertujuan untuk mengetahui peran kecerdasan emosional, persepsi stres, dan orientasi tujuan terhadap prestasi akademik siswa SMA di Bogor. Sebanyak 400 siswa berpartisipasi dalam penelitian ini dengan mengisi kuesioner laporan diri. Hasil analisis regresi berganda menunjukkan bahwa kecerdasan emosional dan orientasi penguasaan tujuan merupakan prediktor positif yang signifikan terhadap prestasi akademik, sedangkan persepsi stres merupakan prediktor negatif yang signifikan. Orientasi tujuan kinerja tidak berhubungan signifikan dengan prestasi akademik. Temuan ini menunjukkan bahwa kecerdasan emosional, orientasi tujuan penguasaan, dan stres yang dirasakan merupakan faktor penting untuk dipertimbangkan dalam meningkatkan prestasi akademik di kalangan siswa SMA. Penelitian lebih lanjut diperlukan untuk mengeksplorasi mekanisme yang mendasari hubungan ini dan mengembangkan intervensi yang efektif untuk mempromosikan faktor-faktor ini.
Hubungan Parenting Style, Peer Pressure, Self-Esteem, dan Kesehatan Mental pada Remaja Indonesia di Jawa Barat
Authors: Lubis Fatimah Malini , Mahendika Devin
Published: April 2023

Penelitian ini bertujuan untuk mengetahui hubungan antara pola asuh, tekanan teman sebaya, harga diri, dan kesehatan mental pada mahasiswa Indonesia di Jawa Barat. Sebuah studi cross-sectional dilakukan, dan data dikumpulkan menggunakan kuesioner yang dikelola sendiri. Studi ini melibatkan 500 mahasiswa berusia 18-25 tahun. Hasil penelitian menunjukkan bahwa pola asuh, tekanan teman sebaya, dan harga diri berpengaruh signifikan terhadap kesehatan mental mahasiswa. Gaya pengasuhan otoritatif dan harga diri yang tinggi ditemukan memiliki efek positif pada kesehatan mental, sedangkan tekanan teman sebaya memiliki efek negatif. Studi ini menunjukkan bahwa intervensi yang ditujukan untuk mempromosikan gaya pengasuhan otoritatif, hubungan teman sebaya yang sehat, dan harga diri dapat berguna dalam meningkatkan hasil kesehatan mental di kalangan mahasiswa.
Tinjauan Hukum Islam Terhadap Istri Yang Memilih Berkarir
Authors: Rendra Robi
Published: April 2023

This study aims to review Islamic law on wives who choose a career in their daily activities. This study used a normative qualitative method. It used both primary data and secondary data. Data analysis used the descriptive analysis method. The results of this study showed that scholars have different opinions about wives who choose careers. Indeed, there is no explicit prohibition in Islamic teachings about wives who choose a career and work outside the house both in stable and unstable family economic conditions. Moreover, referring to the Islamic teachings, wives who choose a career have to pay attention to the boundaries and rules of Islamic teachings. Besides, they have to maintain their honor and dignity as female Muslims so that it does not conflict with their nature as a woman.
Synthesis of sulfonamide chalcones as α-glucosidase inhibitors
Authors:   , Sukanadi I
Published: April 2023

Diabetes mellitus occurs from deficiencies in insulin secretion or insulin resistance which leads over time to high risk for long-term macro-and microvascular complications. Diabetes mellitus type 2 contributes to more than 90% of all cases worldwide. One approach of treatment for this disorder is utilizing α-glucosidase inhibitors. Certain sulfonamides and chalcones are considered as viable candidates that are effective in reducing hyperglycemia. Forty-seven sulfonamide chalcones were synthesized by the Claisen-Schmidt reaction with various substituents on the A, B, and C-rings furnishing the desired products with 50-95 %yield. All compounds were-tested for α-glucosidase inhibitory activity. Twenty-nine compounds exhibited a very strong inhibitory activity with IC50 below 10 µM, eleven with strong activity (IC50 10-49.9 µM), eight with moderate activity (IC50 50-99.9 µM), five with weak activity (IC50 100-199.9 µM), and two not active (IC50 >200 µM). The sulfonamide chalcones bearing p-NHR on the A-ring (62) strongly influenced α-glucosidase inhibition, as well as 3-methoxy (65) on the B-ring. The alkyl substituents (67-72) on the B-ring gave a very strong inhibitory activity and followed by the halogen substituents (73-75). Surprisingly, 63 without any substituent also displayed a very strong inhibitory activity with IC50 0.07±0.01 µM. Moreover, disubstituents on the B-ring such as 3-hydroxy-4-methoxy (86) revealed superior activity with IC50 0.12±0.01 µM. In general, the substituent on the C-ring gave a significant increment of the α-glucosidase inhibitory activity. The 4-methoxy substituent (94) increased the activity by 783 times more than the unsubstituent one (92). Comparing with sulfonamide acetophenones, the sulfonamide chalcones increased the activity by the value of 4-38 times. From Lineweaver-Burk plot for 62 and 86, the inhibition type was disclosed to be uncompetitive while those for 63 and 94 were non-competitive and mixed-mode inhibitors, respectively.
A comparative study of road traffic violation between Thai and Japanese students
Authors:   , Katanararoj Napattharakorn
Published: April 2023

During the last ten years. Accidents of vulnerable road users in Thailand have increased significantly and hit the most severe accident in 2017, especially teenagers between 15-19 year-old. When comparing to Japan in 2017, Japan has reached the lowest accident of all-time since 1960. Considering differences, there are differences in attitudes and behavior toward violation behavior. This study aims to analyze the factor affecting violation behavior between Thai and Japanese to determine the appropriate policies and recommendations. By studying road user's behavior and attitude based on the theory of planned behavior (TPB) in Bangkok, Thailand and Sapporo, Hokkaido, Japan. Questionnaires with road user violation behaviors were designed and developed for each country, and the surveys were conducted and distributed. The 201 samples in Japan and 477 samples in Thailand were collected, which have been valid responses. The validity and reliability of the questionnaire were evaluated. The data were analyzed by using the structural equation model (SEM). It was found that all of the models were significant. In Japan, the bicycle and the pedestrian model were used. Found that the most impactful factors of the bicycle model were notice failure and bicycle stun. Besides, for the pedestrian model were Instrumental attitude and conformity tendency. In Thailand, the motorcycle and the pedestrian model were used. The most impactful factors were traffic error and motorcycle stunt. For the pedestrian model were instrumental attitude, descriptive norm, and conformity tendency. It could be concluded that promoting the awareness of violation and accident by teaching the exact way to ride a motorcycle in detail and realize how they could decrease injuries and violations. However, in the community to prevent accidents, the community has to make the environment safe, build healthy communities and societies, give teenagers importance, and open up opportunities for adjustment. Lastly, the activities and promoting should emphasize parents and companions about the intention to violate the traffic rule. Moreover, cultivate consciousness in their own behavior.
Three-dimensional finite element analyses for optimal ground improvement for tunnel cross passage in Bangkok subsoils
Authors:   , Seng Mengly
Published: April 2023

Jet grouting is a common technic for improving the stability during the construction of tunnel cross-passages in soft grounds. In this study, the optimal soil-cement mass for a cross-passage from a tunnel to an intervention shaft in Bangkok subsoils was determined using three-dimensional finite element analyses. The soil-cement mass was assumed to be octagonal prism along the route of the cross-passage which has the radius of 2.25m. The result showed that the factor of safety increases linearly with the improvement radius. The improvement radius of 3.60m was selected since it is satisfied with the FS more than 1.4 and the thickness is more than 0.1m to prevent from the short-term seepage problem.  In addition, the relationship between the improved groundmass and ground surface settlement curve was made. It was found that the predicted settlement profile can be captured by the formula proposed by Peck and O'Reilly providing that the empirical coefficient of 0.6 agrees well with the results from the 3D simulation and this value was obtained from the average of K = 0.4 and K = 0.7 which is the empirical coefficient value of stiff clay and soft clay respectively based on the overburden thickness.
Predictive factors for identifying macrolide responder in treating chronic rhinosinusitis
Authors:   , Seresirikachorn Kachorn
Published: April 2023

Background: A low-dose macrolide (LDM) has antineutrophilic activity, so they should not work for eosinophilic inflammation. Clinical predictors are required to select favorable patients for LDM therapy appropriately. This study aims to assess individual predictive factors and propose suitable multiple predictive factors for identifying a macrolide responder in treating CRS.

Methodology: Prospective cohort study was done in adult CRS patients. Clinical data collection, Lund-Mackay CT score, visual analog scale (VAS), and sino-nasal outcome test 22 (SNOT-22) were assessed. Patients received 150 mg of roxithromycin once daily plus saline irrigation for 12 weeks. VAS was evaluated at every visit. If the patients had total nasal symptoms VAS > 7 at any visit, they were defined as macrolides non-responders. Nine predictors for macrolide responders were assessed. At the end of treatment, the patients were defined as either macrolide responders or non-responders.

Results: 100 patients (mean–±SD age 47.35 ± 14.13 years, 45% male) with CRS were included. 29 patients met the criteria of macrolide responders. Only local total IgE < 4.76 kU/l (OR: 3.06, 95%CI: 1.16 - 8.06) and serum eosinophils < 3.7% (OR:2.45, 95%, CI 1.01 – 5.93) showed a statistically significant association with macrolide response.  Moreover, in a multivariate regression model, local total IgE was the only variable that maintained an independent association with macrolide response (OR: 3.06, 95%CI: 1.16 - 8.06).

Conclusions: Low local total IgE (< 4.76 kU/l) from nasal secretion may be a suitable predictor for identifying macrolides responders in treating chronic rhinosinusitis with LDM.
A real estate valuation model using boosted feature selection
Authors:   , Chanasit Kankawee
Published: April 2023

To estimate real estate values, a complex valuation model based on artificial neural network (ANN) has been established as a successful means in modern machine learning research, specifically when high-dimensional data are available. Unfortunately, the real estate data in many locations, such as Thailand, are quite limited in terms of features. Hence, it becomes mandatory to reduce the complexity using feature selection techniques. These techniques aim to improve performance by identifying significant factors and help decrease the computational overload and model construction. However, due to the lack of explicability and interpretability in ANNs, the analysis of input factors cannot be explained directly by model composition. In this research, we apply a combination of a boosting strategy and input sensitivity analysis in an improved Garson’s algorithm to perform feature selection that can adjust its selection criteria through each iteration on an ANN model. This proposed technique is then compared with other traditional feature selection techniques using synthetic data and real-world house valuation data. The results show that our model can maintain the sensitivity coefficient for every informative feature. The technique of this study provides a set of features that influences the house price and implies the character of each specific area. It is placed among the top 24% in Zillow Prize competition
Accurate surface ultraviolet radiation forecasting for clinical applications with deep neural network
Authors:   , Raksasat Raksit
Published: April 2023

Exposure to appropriate doses of UV radiation provides enormously health and medical treatment benefits including psoriasis. Typical hospital-based phototherapy cabinets contain a bunch of artificial lamps, either broad-band (main emission spectrum 280-360 nm, maximum 320 nm), or narrow-band UV B irradiation (main emission spectrum 310-315nm, maximum 311nm). For patients who cannot access phototherapy centers, sun-bathing, or heliotherapy, can be a safe and effective treatment alternative. However, as sunlight contains the full range of UV radiation (290-400 nm), careful sun-bathing supervised by photodermatologist based on accurate UV radiation forecast is vital to minimize potential adverse effects. Here, using 10-year UV radiation data collected at Nakhon Pathom, Thailand, we developed a deep learning model for UV radiation prediction which achieves around 10\% error for 24-hour forecast and 13-16\% error for 7-day up to 4-week forecast. Our approach can be extended to UV data from different geographical regions as well as various biological action spectra. This will become one of the key tools for developing national heliotherapy protocol in Thailand. Our model has been made available at github.com/cmb-chula/SurfUVNet.
Direct synthesys of LPG from co2 by using CZZA and HY zeolite hybrid catalyst
Authors:   , Natakaranakul Jaru
Published: April 2023

CO2 conversion to lower hydrocarbons (HCs) is a high-potential method that can significantly reduce and manage this greenhouse gas in the long term. Liquefied petroleum gas (LPG) is widely utilized in transportation. Furthermore, biomass appears to be more attractive for decreasing CO2 emissions through conversion to liquid transportation fuels, as it is a renewable and sustainable energy source. The objectives of this work were to examine the direct synthesis of LPG from CO2 hydrogenation using a mixed metal catalyst composed of copper, zinc oxide, zirconium, and alumina (CZZA), and an HY zeolite as a hybrid catalyst. The study tested four production conditions in a fixed bed reactor with hydrogen/CO2/carbon monoxide as the reactant gas. The mixing between the CZZA and HY zeolite catalysts had a major impact on the HCs selectivity, significantly suppressing the reverse water gas shift reaction. A CO2 conversion rate of 27.39 % was obtained at optimal conditions, along with high selectivity for HC (98.70 %) and LPG (66.56 %). The second part involved a pilot horizontal gasifier to evaluate the Biomass to Liquids Process (BTL). Due to the gasifier's temperature stability at 900 °C, the H2/CO molar ratio remained constant between 1.75 and 2.25. Syngas was converted to liquid fuels at a conversion of 28.56 % in FT synthesis which was caried out at 280 °C and 2 MPa.
Fluorescence sensors from pyreno[4,5-d]imidazole derivatives
Authors:   , Chanawungmuang Nichapa
Published: April 2023

Herein, The five fluorescent probes (P1, P2, P3, P4 and P5) based on pyreno[4,5-d]imidazole were successfully prepared in two steps from pyrene in 26 – 40% overall yields. After that, all of the compounds were studied the photophysical properties and selectivity for sensing metal ions. The results showed compound P5 was not selective to metal ions while the others (P1, P2, P3 and P4) were selective to detection of trivalent metal ions such as Bi3+, Al3+, Cr3+ and Fe3+ in CH3CN. However, only compound P2 with 2-hydroxyl phenyl substituent on imidazole ring formed complexation reaction selectively towards bismuth (III) ions and provided fluorescence enhancement signal attributing to the excited state intramolecular proton transfer (ESIPT) process. Compound P2 exhibited selective fluorescence turn-on at 447 nm. The sensing mechanism was determined by 1H-NMR, and UV-VIS and fluorescence titrations, and the Job’s plot indicated a 1:1 binding between P2 and bismuth (III) ions. The detection limit was 1.20 µM in CH3CN-DMSO (8:2, v/v) mixture and 3.40 µM in 10% aqueous in the mixed 80% CH3CN-DMSO (pH =5). Moreover, the sensor was applied to quantitative analysis of spiked Bi3+ in real water samples from different sources. The recovery of Bi3+ was completed at 91-97%.
Pyrrolidinyl peptide nucleic acid probe capable of crosslinking with DNA
Authors:   , Muangkaew Penthip
Published: April 2023

DNA interstrand cross-linking (ICL) is a phenomenon in which two strands of the DNA (most often as part of the same DNA duplex) bind together via a covalent bond. This process prevents the DNA strand dissociation, which is essential for its biological functions, and thus is extremely damaging to cells. To overcome the problem of non-specificity associated with general DNA cross-linking agents, a cross-linkable probe in which the reactive group is placed on the probe that can specifically recognize part of the DNA target. The strong binding affinity and biological stability of the pyrrolidinyl peptide nucleic acid (acpcPNA) inspired us to develop a new activate-on-demand cross-linkable acpcPNA probe with furan as the reactive moiety, which can be activated by an oxidative process. A simple post-synthetic modification protocol was developed to synthesize such probes and their cross-linking with DNA were studied by thermal denaturation, denaturing PAGE, reverse phase HPLC, and MALDI-TOF MS. The work was divided into two sections. In section I, the effect of the furan position on the acpcPNA strand towards the cross-linking efficiency was investigated. The probe was designed so that the furan moiety was attached to the probe independent from the nucleobase so that it does not interfere with the normal base-pairing process. The results revealed that terminally furan-modified acpcPNA could undergo cross-linking with C > A >> G while the internally furan-modified acpcPNA could not. The G-base was found to participate in such cross-linking with furan for the first time. The C-inserted DNA sequences could enhance the cross-linking efficiency of the internally furan-modified probe. It was concluded that the essential factor of the successful cross-linking reaction is the availability of the nucleobase nearby the furan activated moiety in addition to the ability of the probe to form a stable hybrid with the target. In section II, the cross-linking efficiency of the acpcPNA and aegPNA modified with various furan building blocks at the terminal were compared. The results showed that various furan building blocks and various PNA types of probe offered different cross-linking efficiency and selectivity. In most cases, aegPNA probes showed somewhat higher cross-linking yields over acpcPNA probes, but the latter showed a higher selectivity toward C-base. In addition, a study of internally cross-linking with acpcPNA probes was performed with various DNA targets, and the cross-linking reaction was most efficient when there was a free C-base present at or adjacent to the opposite position of the furan building block. Overall, the major conclusion obtained from the study is that both the ability to form a stable duplex and the availability of the unpaired DNA nucleobase with an exocyclic amino group (A, C, G) were essential for the cross-linking reaction, which provides further insights into the requirements for an efficient ICL formation.
Effect of pyridoxal phosphate and tetrahydrofolate bound on human serine hydroxymethyltransferase by molecular dynamic simulation
Authors:   , Wongpituk Peerapong
Published: April 2023

Serine hydroxymethyltransferase (SHMT), a pyridoxal phosphate (PLP)-dependent enzyme, is involved in one-carbon metabolism in multiple biochemical pathways, including the biosynthesis of purine and thymidine. SHMT1 is the enzyme to be studied clinically as a target for cancer chemotherapy. Therefore, the binding mechanism of this enzyme would be investigated. In this study, molecular dynamics simulations for 500 ns was applied on SHMT1 tetramer in six systems with different ligand cofactors (PLP-Lys, L-ser, PLS, PLG, THF, and MTHF) in order to understand its structural dynamics properties. The key residues Y’73, S53, H231, K257, R263 and R402 were found in all ligand cofactor/SHMT1 systems. All ligand cofactors of each SHMT1 system were stabilized by a strong hydrogen bond with S119 and G120 residues. In addition, the PLS and PLG systems showed strong stabilization with SHMT1 rather than THF and MTHF. Among systems, the MTHF/PLG ligands in system 5 showed the highest binding affinity with SHMT1. Our results could be used as theoretical guidance for inhibitor developments toward SHMT1, which targeting anti-cancer inhibitors
Recovering Genesis One from Scientific and Societal Misunderstanding
Authors: Dickin Alan
Published: April 2023

The Genesis 1 creation story is an enigma to modern society because it reads like a historical account, and yet does not accord with scientific descriptions of origins. The cosmic temple model explains some of the puzzling features of Genesis 1, including its six/seven-day structure. However, it leaves many unanswered questions, including the watery beginning of the earth, in contrast to the desert-like beginning of creation in Genesis 2. Nevertheless, the watery beginning and seven-day structure of Genesis 1 provide links with the biblical and Mesopotamian Flood stories. In addition, the stages of creation in Genesis 1 seem to closely mirror the re-creation of the earth after the Flood. This leads to the suggestion here that Genesis 1 was revealed as a series of visions inspired by the experience of Noah’s Flood. Inspiration of the creation story by the cosmic Flood would have grounded the account in historical reality, and also served to intensify its spiritual message. However, this implies that attempts to find concordance between Genesis 1 and scientific accounts of origins are mistaken. Instead, seeing Genesis 1 as a True Myth inspired by the Flood imparts the reality of God’s creation at a deeper level of human experience than a rational scientific explanation could ever achieve.
Supporting Students on the (Academic) Margins: An Equity-Driven Framework
Authors: Virtue Emily , Lytle Lett Erika , Cheshire Grace , Brown Diamond , Gregory Whitney
Published: April 2023

Though many colleges and universities claim tobe driven by missions that highlight access, equity, and student success, academic policy andpractice do not always mirror these claims. American higher education institutions are “obsessedwith smartness” (Astin, 2017), yet fail to supporteducational attainment in an equitable manner. Educational inequality has its roots in PK–12 education(Dorn, 2017; Ladson-Billings, 2007) particularly asit relates to deficit ideology. The manifestations ofdeficit ideology in higher education are most starkly seen in how students on academic warning (also referred to as academic probation) are treated bothin action and by policy. For higher education institutions to meet their missions for access, equity, andsuccess, they must address how their “systems ofsupport” perpetuate deficit thinking. As the natureof higher education and the demographics of thoseenrolled continues to change and diversify, the timeis right for higher education practitioners to interrogate and change harmful practices. We offer aframework for how institutions can build capacityfor academic support program staff to identify deficit practices that systemically perpetuate inequities,so we no longer hinder student growth and academic success.
PENERAPAN KRIPTOGRAFI CAESAR CIPHER PADA FITUR PESAN TEKS
Authors: Samsuriah  , Ida
Published: April 2023

The progress of communication in the era of technological development where applications and communication support in various ways are increasingly sophisticated indicates that more and more people need access and relationships in every existing communication. Therefore, data or information security is needed to maintain confidentiality. One way to secure data or information is with Cryptology. Cryptography is the study of posting security (confidentiality), cryptographic algorithm techniques consisting of substitution and transposition techniques. Cryptographic methods or techniques can be trusted to deal with data or information security problems, because apart from using computer programming languages, cryptography also uses mathematical formulas, ranging from simple formulas to complex formulas. From the results of the study it can be concluded that with the formula used in the Caesar Cipher cryptographic method, it can be said that even though the Caesar Cipher is difficult to solve, it can be easily solved using mathematical formulas and using a programming language to obtain encryption and decryption results.
Liberdade e neurociência: como a metafísica de Schopenhauer responderia ao determinismo neurológico?
Authors: Orrutea Filho Rogério Moreira
Published: April 2023

Experimentos realizados por neurocientistas como Benjamin Libet e Michael Gazzaniga, sugerem a impossibilidade de haver liberdade nas ações individuais. Embora os dois referidos cientistas tenham elaborado teorias e experimentos um tanto distintos entre si, o resultado geral é o de que o cérebro decide independentemente da consciência do agente. Neste artigo, mostramos que tais experimentos podem ser qualificados como a confirmação empírica daquilo que o filósofo Arthur Schopenhauer, já no século XIX, afirmava a partir de argumentos apriorísticos, baseando-se no princípio de razão suficiente. No entanto, Schopenhauer também sustentou uma teoria da liberdade a partir do caráter do agente, em lugar de sustentar o livre-arbítrio das ações. Veremos que esta teoria schopenhaueriana da liberdade não fora afetada pelos trabalhos de Libet e Gazzaniga, uma vez que, na melhor das hipóteses, os dois cientistas teriam comprovado a ausência de liberdade das decisões singulares, restando intocada a questão sobre a constituição moral do agente.
Biodiversidade de mamíferos em área protegida da Mata Atlântica: um levantamento in situ
Authors: Roma Talita Nazareth de , Riondet-Costa Daniela Rocha Teixeira , Reis Leonardo Frasson dos , Botezelli Luciana
Published: April 2023

A riqueza, ocorrência, diversidade e uniformidade de mamíferos foram avaliadas na região noroeste da Reserva Biológica Serra dos Toledos no município de Itajubá, Estado de Minas Gerais, Brasil. A riqueza foi estimada por métodos diretos e indiretos e calculada usando Jackknife de primeira e segunda ordem. Os índices de diversidade de Shannon-Wiener e Simpson, bem como o índice de uniformidade de Pielou revelaram um ambiente diverso, com valores de 2,539, 0,8806 e 0,799, respectivamente. A interpretação dos dados sobre tais aspectos da diversidade indicou heterogeneidade ecológica nos mamíferos da área avaliada. Este levantamento identificou 24 espécies de mamíferos: 21 selvagens e três domésticos; permitiu traçar um quadro inicial da diversidade de mamíferos desta reserva florestal, dada a falta de dados publicados sobre este grupo faunístico na região. Para realizar um levantamento de mamíferos em tais ambientes, um esforço amostral maior e em área maior mostra-se mais eficaz do que em uma área representativa. Além disso, levantamentos sobre a distribuição geográfica de mamíferos em florestas tropicais são cruciais para avaliar as prioridades de conservação na América do Sul. A presença de humanos e espécies de mamíferos domésticos registrados ao longo do estudo revela a fragilidade dessa área protegida; portanto, o monitoramento e a vigilância devem ser melhorados para evitar a livre movimentação desses indivíduos dentro dessa reserva florestal.
LKPD BERBASIS STEM-5E LEARNING CYCLE UNTUK MENINGKATKAN KEMAMPUAN BERPIKIR KRITIS PADA SISWA SMA
Authors: Usada Nur Iqlima , Hakim Abdul , Qadar Riskan
Published: April 2023

Penelitian ini bertujuan untuk mengembangkan sebuah lembar kerja peserta didik (LKPD) berbasis STEM-5E Learning Cycle untuk meningkatkan kemampuan berpikir kritis siswa SMA kemudian menguji validitas dari LKPD tersebut. Jenis penelitian ini merupakan penelitian pengembangan R&D (research and development) dengan mengadopsi prosedur 4D Models yang mencakup atas 4 tahapan yakni tahap pendefinisian (define), tahap perancangan (design), tahap pengembangan (develop), dan tahap penyebaran (disseminate) yang kemudian dimodifikasi menjadi 3D Models dengan tahapan yaitu antara lain tahap pendefinisian (define), tahap perancangan (design), dan tahap pengembangan (develop). Instrumen yang digunakan adalah lembar validasi yang diberikan kepada tiga orang dosen ahli dan sembilan orang guru. Hasil penelitian menunjukkan jika LKPD berbasis STEM-5E Learning Cycle untuk meningkatkan kemampuan berpikir kritis siswa SMA termasuk dalam kategori valid dengan nilai validitas di atas 80% dan memiliki klasifikasi yang berada pada rentang baik hingga sangat baik berdasarkan pada penilaian yang telah diberikan oleh validator ahli ditinjau dari aspek didaktik, aspek kualitas isi, dan aspek teknis.