bluuebunny/crossref_metadata_2025 huggingface dataset:
Phát triển dòng cá tra (Pangasianodon hypophthalmus) chịu mặn thích ứng với biến đổi khí hậu
Authors: Dương Thúy Yên , Đào Minh Hải , Đặng Quang Hiếu , Bùi Minh Tâm , Phạm Thanh Liêm , Bùi Thị Bích Hằng , Đỗ Thị Thanh Hương , Patrick Kestemont , Frédéric Farnir , Nguyễn Thanh Phương
Published: October 2022

Phát triển dòng cá tra chịu mặn để thích ứng với biến đổi khí hậu có ý nghĩa quan trọng đối với nghề nuôi cá tra ở Đồng bằng sông Cửu Long. Trong 5 năm qua, chúng tôi đã thành công trong chọn lọc được dòng cá tra chịu mặn đến 10‰. Cá thành thục tốt ở 5‰ với các chỉ tiêu sinh sản tương tương với cá nuôi trong nước ngọt. Tỷ lệ sống của nhóm cá chọn lọc và không chọn lọc tương đồng nhau ở độ mặn từ 0‰ tới 15‰ và cao hơn nhóm cá nước ngọt mặc dù khác biệt không có ý nghĩa (p>0,05). Sau một thế hệ chọn lọc trong nước lợ, hệ số di truyền về khối lượng là 0,29, tăng trưởng khối lượng tăng 18,0% và tỷ lệ sống tăng 11,4%. Nghiên cứu về sinh lý học cho thấy cá tra có khả năng sinh trưởng ở 15‰ và độ mặn 20‰ được xem là giới hạn chịu đựng của cá tra. Đường ruột của cá phản ứng mạnh nhất với sự thay đổi áp suất thẩm thấu của môi trường so với các cơ quan khác. Phương pháp “hormesis” ...
Kinh nghiệm của Hoa Kỳ và EU về quản lý mức dư lượng tối đa thuốc bảo vệ thực để phát triển nông nghiệp bền vững - Kiến nghị đối với Việt Nam
Authors: Trần Vang Phủ
Published: October 2022

Một trong những thách thức lớn nhất đối với hàng nông sản của Việt Nam hiện nay là việc bị quốc gia nhập khẩu cảnh báo hoặc cấm nhập khẩu do vi phạm quy định về mức dư lượng tối đa (MRL) thuốc bảo vệ thực vật (BVTV). Bài viết này phân tích kinh nghiệm của Hoa Kỳ và EU trong cách thức tổ chức cơ quan quản lý nhà nước đối với thuốc BVTV và thiết lập MRL để bảo vệ sức khỏe người tiêu dùng, bảo vệ môi trường và phát triển bền vững nền nông nghiệp, từ đó xây dựng một số kiến nghị để hoàn thiện quy định pháp luật Việt Nam như: (i) cần thành lập một cơ quan quản lý nhà nước về thuốc BVTV và thiết lập MRL thuốc BVTV để thống nhất quản lý thuốc BVTV trên phạm vi cả nước, nhằm chống sự chồng chéo hoặc đùn đẩy trách nhiệm giữa các cơ quan hữu quan; (ii) cần quy định MRL cụ thể cho loại thuốc đã cấp, qua đó hạn chế được tình trạng thuốc được sử dụng trên thị trường mà không có căn cứ, tiêu chuẩn để...
Biến đổi khí hậu và nuôi tôm thâm canh vùng ven biển Đồng bằng sông Cửu Long: Những khía cạnh kinh tế, xã hội và môi trường
Authors: Nguyễn Thùy Trang , Võ Hồng Tú , Lê Thanh Sơn
Published: October 2022

Diễn biến thời tiết thất thường và xâm nhập mặn cùng với sự bất ổn định về thị trường làm cho việc thay đổi mô hình sản xuất để thích ứng diễn ra như là một hiện tượng tất yếu. Nghiên cứu được thực hiện nhằm (1) phân tích thực trạng biến đổi khí hậu và chuyển đổi mô hình sản xuất nông nghiệp sang tôm vùng ven biển; (2) phân tích hiệu quả kinh tế, môi trường và thực trạng về tính dễ bị tổn thương của nông hộ nuôi tôm (3) đề xuất giải pháp nâng cao hiệu quả kinh tế, môi trường và giảm tính dễ bị tổn thương cho nông hộ nuôi tôm. Nghiên cứu thực hiện phỏng vấn 125 nông hộ đã chuyển đổi sang mô hình nuôi tôm vùng ven biển tại tỉnh Kiên Giang và Sóc Trăng. Phương pháp phân tích giới hạn biên ngẫu nhiên được sử dụng để ước lượng hiệu quả kinh tế và môi trường và chỉ số tổn thương sinh kế để phân tích về khía cạnh xã hội. Kết quả nghiên cứu cho thấy mức hiệu quả kinh tế và môi trường trung bình của...
Xây dựng nhóm sinh hoạt chuyên môn trực tuyến thông qua mong đợi của giáo viên các cấp đối với mô hình “Teacher Activity Groups”
Authors: Lê Thanh Thảo , Phương Hoàng Yến , Đỗ Thành Nhân , Bùi Nhã Quyên
Published: October 2022

Cải cách giáo dục được thực hiện rất quyết liệt nhằm phát triển tối đa tiềm lực của người Việt Nam để cạnh tranh với các nước trong khu vực và quốc tế. Đáng chú ý, giáo viên các cấp được yêu cầu sử dụng tiếng Anh để giảng dạy các môn Toán và khoa học tự nhiên. Do không đáp ứng được về mặt năng lực ngoại ngữ và cả kỹ năng giảng dạy các lớp học trong đó tiếng Anh được sử dụng làm công cụ hướng dẫn, giáo viên Việt Nam gặp phải nhiều khó khăn và quan tâm khá nhiều đến nhu cầu phát triển chuyên môn. “Teacher Activity Groups” (TAGs), một hình thức phát triển chuyên môn trực tuyến, được thực hiện bởi sự hợp tác của nhiều đơn vị trong và ngoài nước nhằm giải quyết vấn đề trên. Nghiên cứu này được thực hiện để thu số liệu từ 175 giáo viên các cấp tại Đồng bằng sông Cửu Long chuẩn bị tham gia TAGs...
The Extradition Bill of Hong Kong revisited, the National Security Law and the irony of human rights protection in “one country, two systems”
Authors: Lemos Miguel , Costa Miguel João
Published: October 2022

This article focuses on two recent episodes that shook the Hong Kong Special Administrative Region of the People’s Republic of China. It analyzes the main features of the failed Extradition Bill and confronts them with those of the National Security Law that was later enacted by the People’s Republic of China. It also addresses the question as to whether the latter’s provisions are in breach of the basic policies for Hong Kong agreed upon in 1984 between the United Kingdom and the PRC. It concludes that, rather ironically, while the failed Extradition Bill was largely in tune with those basic policies and the human rights protections enshrined therein, the National Security Law is not.
No siempre el procedimiento monitorio es garantía de eficiencia en el proceso penal: el caso de Portugal y España
Authors: Oliver Guillermo
Published: October 2022

En este trabajo se examinan los procedimientos penales monitorios de Portugal y España y se analiza el porqué de su escasa aplicación práctica. Para cada uno de aquellos procedimientos, tras una descripción y una breve valoración crítica de los mismos, basadas principalmente en doctrina de ambos países, se intenta establecer algunas razones que puedan explicar el porqué de su poca aplicación. El trabajo termina con unas breves consideraciones finales, en las que se sintetizan aquellas razones y se afirma que la situación de dichos procedimientos demuestra que la “importación” de instituciones exitosas de sistemas procesales penales foráneos no asegura que su aplicación en el propio sistema también sea exitosa.
Vigencia de la dogmática penal en los sistemas de enjuiciamiento criminal que coexisten en Colombia
Authors: Hernández-Jiménez Norberto , Mestre-Ordoñez Jose Fernando
Published: October 2022

En este artículo se analizan algunas situaciones evidenciadas en la tramitación del rito procesal colombiano, como (i) las implicaciones del juzgamiento en ausencia del procesado, (ii) la afectación de la congruencia entre acusación y sentencia, (iii) la contabilización de los términos de prescripción, (iv) la diferenciación del archivo y la preclusión y (v) la adecuada relación de hechos jurídicamente relevantes. Con base en lo anterior, se cuestiona si ¿la solución procesal de los diferentes asuntos criminales puede concretarse sin necesidad de abordar las cuestiones sustanciales y la aplicación de la dogmática penal? Recurriendo a una dinámica inductiva y tras agotar una revisión bibliográfica, que incluye el análisis de jurisprudencia colombiana, se concluye que aunque las normas sustanciales y las procesales tienen su propio ámbito de regulación y aplicación, entre ambas debe existir una fusión inevitable, como lo pregonaba Bernardo Gaitán Mahecha.
Conflicting interests of witnesses and defendants in a fair criminal trial
Authors: Lach Arkadiusz , Klubińska Maja , Badowiec Renata
Published: October 2022

This study determined whether an adequately regulated hearing by videoconference can become (alone or in conjunction with other measures) an instrument to balance the protection of the rights of the accused with the protection of the interests of witnesses in the criminal process. The authors identified the requirements that a hearing by videoconference must meet the standards established by the European Court of Human Rights. They performed a critical analysis of the existing provisions relating to hearing in Polish criminal procedural law and the practice of their application and showed why in some situations, hearing by videoconference seems to be the most optimal form of hearing. Particular attention was paid to witnesses with specific needs for protection during a hearing. These considerations led the authors to the general (i.e., not exclusively applicable to the Polish legal order) conclusion that hearing by videoconference is a very useful instrument for realising fair trial standards and witness protection.
A vueltas con la duda razonable y la lógica difusa:
Authors: Vera Juan Sebastián
Published: October 2022

En este trabajo se explorará la utilización de la lógica de los enunciados difusos a la aplicación del estándar de la duda razonable que está presente en buena parte de los sistemas de justicia penal de la cultura del common law y del civil law. Sugeriré la construcción de una regla heurística que opere sobre la base de la ponderación de las generalizaciones epistémicas y la relación entre ellas respecto de la hipótesis inculpatoria a través de la aplicación de las propiedades de la unión y conjunción de la lógica difusa.
Breast Lymphoma
Authors: rayamajhi kundana , Bansal Richa , Aggarwal Bharat
Published: October 2022

Primary breast lymphomas are a very rare group of breast malignancies
.Imaging findings in lymphoma are nonspecific and whole body imaging is
an essential part of the workup to rule out disease in other parts of
the body and to be labelled as primary breast lymphoma
PARADIGMA SUNNI TAFSIR KH. AHMAD BASYIR (1930-2017) DALAM PERSPEKTIF TEKSTUALITAS GRACIA
Authors: Mahmudi Mahmudi , Wardi Moh.
Published: October 2022

Artikel ini menganalisis tafsir lokal Madura yang ditulis oleh KH Ahmad Basyir (1930-2017) yang dianggap sebagai pejuang dan ulama pada masanya. Ahmad Basyir merupakan tokoh yang sangat disegani, khususnya di Sumenep, bahkan di Madura. Metode dalam artikel ini adalah studi pustaka dengan fokus kepada Kitab at-Tafsir jilid I karyanya. Penulis berargumen bahwa tafsir yang ditulisnya merupakan tafsir paradigma sunni yang mengedepankan etika hamba dalam hubungannya dengan Tuhan. Dalam proses analisis, penulis menggunakan perspektif tekstualitas Gracia dan berusaha mencari relevansinya atas realitas Indonesia sekarang. Penulis beranggapan bahwa corak penafsiran Ahmad Basyir menyodorkan paham Islam yang relevan di tengah merebaknya paham radikalisme agama.
PENERJEMAHAN RAMAH GENDER
Authors: Afifah Farida Nur
Published: October 2022

Artikel ini dilatarbelakangi oleh adanya penerjemahan bias gender dalam terjemahan Al-Qur’an Kementerian Agama tahun 2002 yang kemudian direvisi tahun 2019. Permasalahan yang diangkat, yaitu bagaimana metode dan kualitas penerjemahan terhadap ayat-ayat terkait gender dalam Al-Qur’an dan Terjemahnya edisi penyempurnaan 2019? Sumber data dianalisis menggunakan teori penerjemahan Peter Newmark untuk ranah metode, serta teori ekuivalensi Husein Abdul-Raof untuk menimbang kualitas terjemahan. Artkel ini menyimpulkan, pertama, metode terjemahan didominasi terjemahan komunikatif. Hal tersebut dilihat dari beberapa terjemahan yang lebih berorientasi pada penerima bahasa sasaran, banyaknya penjelasan baik singkat atau detail, sebagaimana penjelasan dalam bentuk catatan kaki atau keterangan dalam kurung. Kedua, terjemahan lebih didominasi kesepadanan level semantik dan stilistik, sehingga dapat dikatakan terjemahan ayat-ayat terkait gender sudah memahamkan dan tidak mengandung bias gender. Sedangkan dalam ketidaksepadanan didominasi level budaya, karena budaya antara penerima bahasa sumber dan bahasa sasaran berbeda.
Moderatisme sebagai Konsep Berkehidupan Bersama dalam Perspektif Tafsir Al-Qur’an Kontemporer
Authors: Abdurrahman Landy Trisna
Published: October 2022

Senyatanya, masih banyak kalangan yang tidak siap hidup bersama kelompok lain yang berbeda. Dalam konteks Indonesia, pelanggaran kebebasan beragama dan berkeyakinan sepanjang tahun 2019 mencapai angka di atas 215 kasus. Di Amerika, orang kulit hitam muslim terbunuh oleh seorang tetangga berkulit putih. Padahal sejatinya, agama yang berdasar pada keyakinan bisa menjadi kritik terhadap masalah berkehidupan bersama. Islam adalah agama yang bersumber dari wahyu. Interpretasi atas wahyu (Al-Qur’an) memiliki peran sangat penting untuk menjadi dasar perilaku mewujudkan kehidupan bersama yang damai: menjadi moderat. Artikel ini mencoba menelusuri pandangan tafsir kontemporer terhadap interpretasi kata moderat dan live together yang ada dalam Al-Qur’an. Penelitian ini adalah penelitian kualitatif dengan sumber data dari berbagai tafsir kontemporer. Temuan dalam artikel ini adalah tujuan yang harus dicapai dalam berkehidupan bersama adalah menjaga kedamaian. Sedangkan menjadi moderat adalah sebuah proses dialog antar berbagai perbedaan dan kepentingan yang ada dalam manusia. Perilaku moderat hanya akan bisa dicapai dengan keterbukaan pikiran dan tanpa kecurigaan terhadap perbedaan.
Literature Analysis of Tafsīr Tarbawiy (Qur’anic Educational Interpretation) from Paul Ricoeur’s Hermeneutic Perspective and Its Relevance as A Source of Islamic Education
Authors: Rosidin Rosidin , Andriani Fenty
Published: October 2022

This paper analyzes nine tafsīr tarbawiy (Quranic educational interpretation) literatures in Indonesia from Ricoeur’s hermeneutics perspective. There are two main research findings. First, as objective pole, tafsīr tarbawiy terminology meaning structure as Qur’anic educational interpretation written by Islamic experts for pragmatic and idealistic purposes. As subjective pole, tafsīr tarbawiy literature discussing Islamic education by quoting educational verses through the thematic interpretation (mauḍūʻī) method using various references, according to the author’s subjectivity. There are strengths and limitations of tafsīr tarbawiy literature. The strength is it opens the way for construction of tafsīr tarbawiy literature which is solutive and realistic. The limitation is its interpretation is ideological and utopian. Second, tafsīr tarbawiy literature is relevant as a source of Islamic education theory and practice since it is prepared for pragmatic purposes as a reference for tafsīr tarbawiy course, written by the Islamic education theorists and practitioners, and contains a thick discussion on issues of Islamic education, though the quality and validity are graded, based on the competence level which is the author’s appropriation.
Current strategies for the treatment of acute myeloid leukemia
Authors: Suvajdzic-Vukovic Nada , Mitrovic Mirjana , Virijevic Marijana , Vidovic Ana , Cvetkovic Zorica
Published: October 2022

Introduction. Acute myeloid leukemia is a rare malignancy with an average age
of 70 years at diagnosis. Until recently, five-year survival of younger
patients with this disease, despite being treated with allogenic
hematopoietic stem cell transplantation, was < 30%, while in patients older
than 60 years it was < 10%. Treatment overview. Due to the heterogeneity of
acute myeloid leukemia no new drugs for treating this disease have been
introduced for decades. The introduction of new drugs began from 2017:
midostaurin, gilteritinib, CPX351, enasidenib, ivosidenib, venetoclax,
glasdegib, while gemtuzumab ozogamicin has been reintroduced. Modern
treatment strategies require an individual approach, based on prognostic
parameters such as cytogenetical and molecular profile of acute myeloid
leukemia at diagnosis and the assessment of minimal residual disease
evaluated after two cycles of chemotherapy. Moreover, determining the
eligibility of patients for ??intensive?? treatment, based on functional
status, comorbidities and geriatric assessment of older patients, is
necessary. Regarding the treatment of acute promyelocytic leukemia, the
combination of arsenic trioxide and all-trans retinoic acid is universally
accepted as the standard of care for non-high risk patients (WBC <
10x109/L), while standard chemotherapy combined with all-trans retinoic acid
is still used for high-risk patients (WBC >10x109/L). Conclusion. Novel
therapeutic modalities, along with allo-HSCT have changed the outcome of AML
patients. However, treating patients unfit for intensive chemotherapy, as
well as patients with relapse/refractory disease, is still challenging.
Treatment of patients with acute lymphoblastic leukemia who are not suitable for high-dose chemotherapy and hematopoietic stem cell transplantation
Authors: Govedarovic Nenad
Published: October 2022

Introduction. Acute lymphoblastic leukemia is a malignant disease
characterized by the proliferation of precursor B-cells, Tcells or less
often, precursors of NK-cells. B-cell acute lymphoblastic leukemia is more
common in patients >60 years of age compared to patients <60 years of age
(89% vs. 66%), and cytogenetic abnormalities such as t(9;22) (Ph+) are more
common in older than younger patients (36% against 19%). Elderly patients
often have a poor status and comorbidities, so poor disease outcome is more
common. Clinical and biological features. B cell acute lymphoblastic
leukemia is more common in patients >60 years of age compared to patients
<60 years of age (89% vs 66%) and cytogenetic abnormalities such as t(9;22)
are more common in older vs. younger (36% vs. 19%). Therapy. The elderly and
patients with comorbidities require less intensive therapy, based on
corticosteroids, vincristine and asparaginase, while avoiding anthracyclines
and alkylating agents, due to the high mortality associated with treatment.
For ?unfit? patients with Ph-positive acute lymphoblastic leukemia, tyrosine
kinase inhibitors with reduced-intensity chemotherapy or corticosteroids
alone are recommended. For t(9;22) negative patients, low-dose
corticosteroid chemotherapy with or without immunotherapy is recommended.
For patients with T-cell acute lymphoblastic leukemia, chemotherapy with
venetoclax may be an option. Conclusion. The introduction of targeted
therapy has changed treatment options in acute lymphoblastic leukemia. For
elderly patients, targeted therapy is a necessary modality since standard
chemotherapy leads to a poor outcome due to its toxicity and
ineffectiveness.
Diagnosis, classification, and prognosis of myelodysplastic syndromes
Authors: Bogdanovic Andrija , Marisavljevic Dragomir , Savic Aleksandar
Published: October 2022

Introduction. Myelodysplastic syndromes represent clonal neoplastic disorders
characterized by hematological dysplasia, ineffective hematopoiesis,
cytopenia, and increased risk of transformation to acute myeloid leukemia.
Material and Methods. A literature review was conducted using the following
bibliographic databases: Google Scholar, MEDLINE, and Kobson. The
recommendations for diagnosis, classification, and prognosis are based on
expert opinions grounded on a review of the literature and contemporary
recommendations for diagnosis and prognosis in myelodysplastic syndrome.
Diagnosis and classification. Diagnosis of myelodysplastic syndrome should
be based on detailed patient and family history, physical examination, and
comprehensive blood examinations in to exclude all other causes of cytopenia
and dysplasia. Mandatory for myelodysplastic syndrome diagnosis is cytology
of blood and bone marrow, bone marrow biopsy with immunohistology and
cytogenetics. 2016 World Health Organization classification should be used
for myelodysplastic syndrome diagnosis. SF1B3 genetic analysis is
recommended in patients with suspected myelodysplastic syndrome with ringed
sideroblasts and p53 mutation status. Prognosis. Revised International
Prognostic Scoring System for myelodysplastic syndrome (IPSS-R) risk score
should be defined for every patient in order to determine prognosis. The
next-generation sequencing could provide additional diagnostic and
prognostic information, particularly in young transplant candidates.
Conclusion. Myelodysplastic syndrome diagnosis is based on the 2016 World
Health Organization classification. The prognosis should be based on the
Revised International Prognostic Scoring System with the possible addition
of genetic analysis.
Resistance to targeted therapy in chronic lymphocytic leukemia
Authors: Milosevic Ivana
Published: October 2022

Targeted therapy with inhibitors of cell signaling pathways and inhibitors of
anti-apoptotic molecules significantly improved treatment of chronic
lymphocytic leukemia. Inhibitors of Bruton?s tyrosine kinase and inhibitors
of bcl2 protein showed significant efficacy in either treatment-na?ve or
relapsed/refractory patients and in patients with poor risk factors. The
majority of patients respond to treatment and have durable remissions, but
some of them develop resistance, which leads to clinical relapse. The most
frequent cause of resistance is mutations on the binding site of targeted
molecules, such as Bruton?s tyrosine kinase mutations in patients treated
with ibrutinib or acalabrutinib, or bcl2 mutations in patients treated with
venetoclax. There are also alternative mechanisms that can lead to
resistance, such as mutations of another molecule in Bruton?s tyrosine
kinase signaling pathway, PLCG2, or overexpression of bcl2 protein. These
mutations have been detected several months before clinical sings of
relapse, and therefore could serve as predictive markers of treatment
failure. When resistance to inhibitors of Bruton?s tyrosine kinase occurs,
treatment with bcl2 inhibitors will be effective in most cases, and vice
versa. Other strategies for overcoming resistance to inhibitors of Bruton?s
tyrosine kinase or bcl2 protein are treatment with PI3K inhibitors, second
and third generation Bruton?s tyrosine kinase inhibitors, bispecific
antiCD3/CD19 antibodies, chimeric antigen receptor T-cells and allogenic
stem cell transplantation. Several molecules, which can inhibit or degrade
different signaling targets in chronic lymphocytic leukemia cells, are
currently under investigation, and they could be effective in patients
resistant to inhibitors of Bruton?s tyrosine kinase and bcl2 protein.
Current principles of follicular lymphoma treatment
Authors: Radojkovic Milica
Published: October 2022

Over the last 10-15 years, the prognosis of patients with follicular lymphoma
has improved, and for the majority of patients, follicular lymphoma is a
chronic disease with ten years of overall survival of around 80%.
Nevertheless, a certain subset of patients belongs to high-risk follicular
lymphoma with early relapses and progressive disease, poor outcomes, and
much shorter survival, and there is still no standard approach in the
treatment of high-risk follicular lymphoma. Treatment of follicular lymphoma
is highly heterogeneous, ranging from a ?watch and wait? strategy to
intensive immunochemotherapy, and needs to be individualized to each
patient. An early stage of the disease can be treated with involved-field
radiotherapy, which has curative potential. Follicular lymphoma in the
advanced stage is still an incurable disease. Standard first-line treatment
is a combination of an anti-CD20 antibody (rituximab) and chemotherapy,
followed by antibody maintenance. In relapse, treatment with novel anti-CD20
monoclonal antibody-obinutuzumab in combination with chemotherapy. The
combination of lenalidomide and rituximab shows good results in patients
with relapses and refractory follicular lymphoma, but also as a first-line
treatment. An option for elderly patients with comorbidities is rituximab
monotherapy. Autologous or allogeneic stem cell transplantation may be an
option for a small group of selected patients. In the past decade
development of novel targeted agents such as phosphoinositide three kinase
inhibitors and immunotherapies (CD20/CD3 bispecific antibody, chimeric
antigen receptor T cell therapy) demonstrate the efficiency of
chemotherapy-free approach not only for relapsed/refractory patients but
also in first-line treatment. A better understanding of the clinical and
biological features of follicular lymphoma patients is necessary to improve
treatment outcomes in the future.
Relapsed/refractory diffuse large B-cell lymphoma - advancements in treatment
Authors: Tarabar Olivera
Published: October 2022

About 40% of patients with diffuse large B-cell lymphoma will develop disease
relapse or refractory disease to first-line rituximabcyclophosphamide,
doxorubicin, vincristine and prednisone chemotherapy, necessitating
second-line therapy. Historically, this consisted of platinum-based
chemotherapy followed by autologous stem cell transplantation for patients
who were transplant-eligible. But not all patients are eligible for
autologous stem cell transplantation and curative treatment options for
these patients were limited. The lack of effective treatment options in the
relapsed/refractory diffuse large B-cell lymphoma had made the prognosis of
these patients poor. In recent years there have been several new therapeutic
agents approved or pending approval for the treatment of relapsed/refractory
diffuse large B-cell lymphoma. These treatments include antibody- drug
conjugates, novel anti CD19 monoclonal antibodies, chimeric antigen receptor
T-cell therapy, bispecific antibodies, and selinexor. This paper reviews
current strategies and novel therapies for relapsed/refractory diffuse large
B cell lymphoma.
Grey zone lymphoma - diagnostic and therapeutic challenge
Authors: Agic Danijela , Lakic Tanja , Nikin Zoran
Published: October 2022

Introduction. ?Grey zone Lymphoma?? is associated with various entities. The
last published classification of lymphoproliferative neoplasms includes
mediastinal grey zone lymphoma. Precise diagnostic criteria are insufficient
and establishing a diagnosis is as complex as deciding on treatment options.
In this article pathologist and hematologist discuss issues on this topic
through case presentation and literature review. Clinical characteristics.
It presents in the younger population usually with a mediastinal mass,
sometimes large, with compressive symptoms. Pathologic characteristics. Some
cases can?t be classified neither as Hodgkin nor Primary mediastinal B-cell
lymphoma. Morphology resembles Hodgkin, but with a positive immunophenotype
for primary mediastinal or diffuse large B-cell lymphoma, and vice versa.
Case report. We presented a case of a 33-year-old male with cervical
lymphadenomegaly, B symptoms and clinical deterioration during the
diagnostic period. After the first biopsy, differential diagnosis was
Epstein-Barr virus-associated lymphoproliferative disorder or classical
Hodgkin lymphoma. The second biopsy confirms Epstein-Barr virus-positive
diffuse large B-cell lymphoma. The World Health Organization Classification
of lymphoproliferative neoplasms - clinical perspective. The term ?grey zone
lymphoma? is associated with overlapping diagnosis or uncertainty in
diagnosis in more clinical settings than the ones provided in the 5th World
Health Organization Classification. Discussion. For now, chemotherapeutic
regimen (rituximab-cyclophos phamide, doxorubicin, vincristine, prednisone)
stays the standard first line therapy for diffuse large B-cell lymphoma
regardless of the Epstein- Barr virus status. Mediastinal grey zone lymphoma
treatment varies: chemotherapeutic regimen (rituximab-cyclophos phamide,
doxorubicin, vincristine, prednisone) was linked with better outcomes than
chemotherapeutic regimen (adriablastin, bleomycin, vinblastine, dacarbazine)
+/-R, but for some patients chemotherapeutic regimen (dose
adjusted-etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin)
might be beneficial. Conclusion. Grey zone lymphoma is a rare hematologic
malignancy that needs extensive sampling for correct diagnosis and is still
subject to inter-observer variability.
Nodular lymphocyte predominant Hodgkin lymphoma with T-cell/histiocyte - rich large B-cell lymphoma pathohistological characteristics and extranodal presentation: Case report and literature review
Authors: Perunicic-Jovanovic Maja , Sarac Sofija , Vukovic Vojin , Otasevic Vladimir , Tomic Kristina , Mihaljevic Biljana , Antic Darko
Published: October 2022

Nodular lymphocyte predominant Hodgkin lymphoma appears in 5% of Hodgkin
lymphoma. Because of major biological and clinical differences with
classical Hodgkin lymphoma and close relationship to T-cell/histiocyte-rich
large B-cell lymphoma, lately the term nodular lymphocyte predominant B-cell
lymphoma is accepted. The presence of lymphocyte predominant cells with
preserved B-cell phenotype and a lack of CD30 is the prerequisite for the
diagnosis of nodular lymphocyte predominant Hodgkin lymphoma. Lymphocyte
predominant cells are typically embedded in large nodules of B lymphocytes
(growth patterns A and B), but variants that are characterized by lymphocyte
predominant cells located outside the nodules, a Tcell- rich nodular growth
pattern and T-cell-rich or B-cell-rich diffuse growth patterns,
respectively, have also been described (growth patterns C, D, E, and F).
Variant growth patterns are associated with the recurrence and progression
of disease and should be recognized and specified in pathology reports.
Broad B-cell immunohistochemical panel, including PAX5, CD79a, Bob.1, and
Oct-2 is indicated in these cases to distinguish between nodular lymphocyte
predominant Hodgkin lymphoma, classical Hodgkin lymphoma and
T-cell/histiocyte-rich large B-cell lymphoma, which have significant
differences in clinical behavior and treatment. There are different
treatment approaches in patients with nodular lymphocyte predominant Hodgkin
lymphoma depending on pathohistological type, clinical presentation and
stage of the disease. Treatment may include active surveillance, radiation
therapy, immunotherapy or chemotherapy. A multidisciplinary approach is
beneficial to optimize the diagnosis and management of patients with nodular
lymphocyte predominant Hodgkin lymphoma.
Hypereosinophilic syndrome - diagnostic and treatment approach
Authors: Lekovic Danijela
Published: October 2022

Hypereosinophilic syndrome is defined as a peripheral blood eosinophil count
? 1.5 ? 109/L associated with tissue or organ damage. Eosinophilic disorders
represent a group of pathological conditions with heterogeneous
pathophysiology, clinical presentation and prognosis. The disease prognosis
is based on identifying the subtype and mechanism of eosinophilia. It is
important to assess the degree of organ damage based on diagnostics that is
directed upon symptoms and signs. After exclusion of secondary causes of
eosinophilia, in 2016, the World Health Organization endorsed an assessment
towards a molecular classification scheme of disease subtypes named clonal
or primary eosinophilias. Diagnostic evaluation of primary eosinophilia
relies on a combination of morphologic review of the blood and marrow,
standard cytogenetics, fluorescence in situ hybridization, flow
immunophenotyping, and a T-cell clonality assessment to detect
histopathologic or clonal evidence for an acute or chronic myeloid/lymphoid
neoplasm. The goal of the therapy is to reduce eosinophil-mediated organ
damage. Depending of cause of eosinophilia therapeutic implications range
from a ?watch and wait? to the implementation of allogeneic hematopoietic
stem cell transplantation.
Von Willebrand disease - detection, diagnostics and treatment
Authors: Rajic Nebojsa
Published: October 2022

von Willebrand disease is the most common inherited bleeding disorder, with
mucocutaneous bleeding and menorrhagia as leading clinical manifestations.
Cause of the bleeding diathesis is deficit or dysfunction of the
vonWillebrand factor, plasma protein with important roles in adhesion of
platelets to the site of vascular injury and transport and protection of
coagulation factor VIII. Prevalance of the disease, according to different
registries, is between 1 von Willebrand disease on 100 persons to 1
von Willebrand disease on 10000 persons. These data shows that detection of
the disorder is not easy and that many cases are undiagnosed. That why
bleeding assessment tools are developed and they are widely used for many
years. Confirmation of the diagnosis is through laboratory testing. Some of
tests are not easily accessible. Therapy of the disorder depends on goals of
the treatment (stopping bleeding, prophylaxis or preoperative management).
Last year, new guideline for diagnostics and treatment of von Willebrand
disease was published by experts of World Federation of Haemophilia,
International Society of Thrombosis and Haemostasis, American Society of
Hematology and National Hemophilia Foundation. In this paper, new
recommendations for detection, diagnostics and treatment of the
von Willebrand disease, are presented.
Tumor lysis syndrome
Authors: Percic Ivanka
Published: October 2022

Introduction. Tumor lysis syndrome is an emergency condition requiring prompt
recognition and treatment. It?s a consequence of spontaneous or
therapy-induced cellular death leading to the release of intracellular ions
and metabolic products of purine bases into the bloodstream.
Pathophysiology. The characteristic metabolic derangement comprises
hyperkalemia, hyperphosphatemia, hyperuricemia, and hypocalcemia. These
metabolic changes can lead to kidney failure, arrhythmia, and seizures.
Epidemiology, classification and risk assessment. The incidence of tumor
lysis syndrome varies between different types of tumors, but it is most
common in hematologic malignancies. According to Cairo - Bishop
Classification, tumor lysis syndrome can be defined as laboratory tumor
lysis syndrome and clinical tumor lysis syndrome. Preventive measures and
treatment of tumor lysis syndrome. Frequent laboratory monitoring is
obligatory in patients with intermediate and high risk of tumor lysis
syndrome. Preventive measures are based on vigorous hydration and
administration of medication to control serum uric acid levels. When
clinical tumor lysis syndrome develops, additional treatment, including
renal replacement therapy, is needed for the correction of metabolic
disturbances. Conclusion. Tumor lysis syndrome is a potentially fatal
complication in patients with suffering from malignancies. Early recognition
of patients at risk and administration of prophylactic and therapeutic
measures improves outcomes for these patients.
Isolation, cohesion and contingent network effects: the case of school attachment and engagement
Authors: Gauthier G. Robin , Smith Jeffrey A. , Harcey Sela , Markowski Kelly
Published: October 2022

Isolation and cohesion are two key network features, often used to predict outcomes like mental health and deviance. More cohesive settings tend to have better outcomes, while isolates tend to fare worse than their more integrated peers. A common assumption of past work is that the effect of cohesion is universal, so that all actors get the same benefits of being in a socially cohesive environment. Here, we suggest that the effect of cohesion is universal only for specific types of outcomes. For other outcomes, experiencing the benefits of cohesion depends on an individual’s position in the network, such as whether or not an individual has any social ties. Network processes thus operate at both the individual and contextual level, and we employ hierarchical linear models to analyze these jointly to arrive at a full picture of how networks matter. We explore these ideas using the case of adolescents in schools (using Add Health data), focusing on the effect of isolation and cohesion on two outcomes, school attachment and academic engagement. We find that cohesion has a uniform effect in the case of engagement but not attachment. Only non-isolates experience stronger feelings of attachment as cohesion increases, while all students, both isolates and non-isolates, are more strongly engaged in high cohesion settings. Overall, the results show the importance of taking a systematic, multi-level approach, with important implications for studies of health and deviance.
Two Distinct Nutritional Assessment Tools Have Dissimilar Outcomes in a Sample of Older Adult Patients With Cancer
Authors: Rios Tatiane Correia , Baqueiro Boulhosa Ramona Souza da Silva , Varjão da Costa Maria Lúcia , Sassaki Betina da Silva , Bueno Allain Amador , de Jesus Rosangela Passo , Magalhães de Oliveira Lucivalda Pereira
Published: October 2022

Introduction

Malnutrition is strongly associated with negative outcomes in aged populations with cancer. Several studies have compared the outcomes of nutritional-screening tools, but knowledge specifically covering older adult patients with cancer remains limited. The aim of this study was to compare the outcomes of two tools, the Patient-Generated Subjective Global Assessment (PG-SGA) versus the Mini Nutritional Assessment (MNA) for this population.

Method

Cross-sectional study with 432 participants who consented to participate and were enrolled at admission to medical and surgical wards of a tertiary referral hospital. The participants’ nutritional statuses were simultaneously assessed using the PG-SGA and the MNA, and the outcomes compared using the kappa statistical test. The Receiver Operating Characteristic Curve (ROC) was employed to calculate the MNA sensitivity, specificity, positive and negative predictive values, and was compared with PG-SGA.

Results

Prevalence of good nourishment was observed in 62.5% and 61.1% of the participants, as detected by PG-SGA and MNA, respectively. Both tools concurred moderately (kappa = 0.453). Importantly, there were significant differences in the diagnosis of malnutrition (7.6% vs. 4.6%, p = 0.000). The MNA showed sensitivity of 72.2% and specificity of 75.9% in detecting good nourishment for the population investigated.

Conclusion

The MNA may not present greater sensitivity, possibly due to a lack of coverage of gastrointestinal symptoms. It is a quick and efficient tool for nutritional assessment of older adult patients with cancer, but as it is more specific than sensitive, caution is recommended when identifying borderline or early malnourished individuals of this population.
Multi-Population-Based Algorithm with an Exchange of Training Plans Based on Population Evaluation
Authors: Łapa Krystian , Cpałka Krzysztof , Kisiel-Dorohinicki Marek , Paszkowski Józef , Dębski Maciej , Le Van-Hung
Published: October 2022

Population Based Algorithms (PBAs) are excellent search tools that allow searching space of parameters defined by problems under consideration. They are especially useful when it is difficult to define a differentiable evaluation criterion. This applies, for example, to problems that are a combination of continuous and discrete (combinatorial) problems. In such problems, it is often necessary to select a certain structure of the solution (e.g. a neural network or other systems with a structure usually selected by the trial and error method) and to determine the parameters of such structure. As PBAs have great application possibilities, the aim is to develop more and more effective search formulas used in them. An interesting approach is to use multiple populations and process them with separate PBAs (in a different way). In this paper, we propose a new multi-population-based algorithm with: (a) subpopulation evaluation and (b) replacement of the associated PBAs subpopulation formulas used for their processing. In the simulations, we used a set of typical CEC2013 benchmark functions. The obtained results confirm the validity of the proposed concept.
Customer Knowledge Management in Enterprise Software Development Companies: Organizational, Human and Technological Perspective
Authors: Khosravi Arash , Rajabzadeh Morteza , Zaloga Viliam , Dyadyura Irina
Published: October 2022

In this study, Knowledge-Based View (KBV) and Theory of Technology in a Generic Customer Knowledge Management (CKM) Framework were assimilated to demonstrate the Organizational, Human and Technological antecedent factors that enable CKM processes to improve software product quality. A Theoretical CKM Framework was developed by extracting Human, Organizational and Technological factors from the literature, then, the “Technique for Order of Preference by Similarity to Ideal Solution” (TOPSIS) Multi-Criteria Decision Making (MCDM) method was applied to find the importance level of factors to CKM development in software companies. The weight and priority of factors were determined by 31 experts in enterprise software development companies. The results show that, from an expert viewpoint, CKM antecedent factors are categorized into high priority and low priority groups. Organizational factors such as “Customer Involvement”, “Customer-Centric Culture” and “CKM Strategy Development” are high priority.
Analysis of Forecasted Methane Concentration at the Top Gate of a Wall Ventilated by Means of the “U” System. Case Study
Authors: Łukaszczyk Zygmunt , Badura Henryk
Published: October 2022

The release of methane into the mine atmosphere poses a threat to the miners. Methane is an explosive gas at concentrations of 5-15% in air by volume and throughout the history of coal mining has been the cause of devastating explosions in mines around the world. For these reasons, in methane coal mines, the concentration of methane emitted from the coal face and the entire mine is controlled by means of a well-designed ventilation system, a system controlling the concentration of methane in the mine atmosphere and a system for methane drainage of the rock mass and goafs. The presented article concerns the forecast of the average concentration of methane on a given day, in the places of sensors located in the longwall roadways of discharge air exhausted from the longwall: up to 10 m in front of the wall and at the outlet of the roadway. Both forecasts were made using the prognostic equations on the basis of measurement data concerning the ventilation roadways of one of the longwalls at JSW SA.
Numerical Simulations of the Exploitation Parameters of the Rotary Feeder
Authors: Karwat Bolesław , Rubacha Piotr , Stańczyk Emil
Published: October 2022

The article presents the problems of determining the mass efficiency of a rotary feeder depending on the selection of design parameters of the device, such as outer diameter, number of blades and rotational speed of the rotor. The hitherto theoretical methods of calculating the feeder efficiency were presented, as well as a new method of determining the device operation parameters was proposed. For this purpose, the numerical Discrete Element Method was used, which allowed simulating the transport of limestone powder in a cell feeder with various design variants. The results of the tests showed that the above design parameters affect the instantaneous efficiency of the feeder and thus impact the distribution of the dosed material during the operation of the device. Depending on the design solution, the simulation results gave information on the fill factor of the feeders. The study showed a significant potential of DEM simulation in the design of circular feeders intended for dosing bulk materials.
Assessment of the Stability of Bev Lhd Loader
Authors: Bołoz Łukasz , Kozłowski Artur , Horak Wojciech
Published: October 2022

The article concerns the computational model for analysing the stability of the BEV LHD loader. Works were carried out to develop an innovative, light battery-powered loader, which was the subject of an R&D project implemented in cooperation with Bumech S. A. Compared to the existing solutions of loaders with similar load capacity, this one is distinguished by the use of an individual electric drive in each wheel and a replaceable battery. A physical and mathematical model was developed taking into account the specificity of the BEV LHD loader. In the model, the masses of the battery, individual drives, the platform and excavated material are taken into account separately. The developed model allows determining the loader wheel pressure on the floor, depending on the location of its components’ centres of gravity, the turning angle of the machine, the amount of excavated material in the bucket and the position of the bucket. The input parameters also include the longitudinal and transverse excavation slope angles. In addition, the model enables determining the inner and outer turning radius of the loader. To verify the theoretical model, dynamic simulation tests were carried out. The results of simulation analyses confirmed the correctness of the developed theoretical model. The model was used to prepare a calculation sheet for analysing the stability on the basis of the adopted parameters. In the article, selected results of the conducted stability analyses have been presented, along with the proposed parameters ensuring the loader’s stability. The developed theoretical model enables a quick assessment of the loader’s stability, which, due to a number of innovative solutions, differs from existing designs. The structure of the loader at the design stage is subject to numerous modifications, which affect the distribution of the centres of gravity of individual components. The developed model of the loader is a useful, parameterized tool that allows assessing the stability and the values of the turning radii of the machine.
General Strength, Energy Efficiency (EEDI), and Energy Wave Criterion (EWC) of Deadrise Hulls for Transitional Mode
Authors: Kanifolskyi Oleksandr
Published: October 2022

In the modern world, environmental issues come to the fore. The document of MARPOL for reducing the emission of pollutants into the atmosphere relates to the energy efficiency coefficient EEDI. This coefficient is directly related to the power of the main engine and, accordingly, to the water resistance. The way to reduce the energy efficiency factor EEDI by increasing the relative length

L

V
3

{L \over {\root 3 \of V }}

of the ship was proposed in this article. To determine the maximum value of the relative length, knowledge of the general strength of the vessel is required. The value of the relative section modulus of an equivalent girder for a small vessel of transitional mode is defined. The result of the graphic solution of two equations is the value of such a relative section modulus. This parameter is required to determine the limiting value of the relative length and to find solutions to reduce the coefficient EEDI. Comparative analysis of the obtained data with the data of the strength and weight of the H-girder with a length similar to the ship was conducted. The formula for determining the limiting value of the relative length was obtained from the equation of general strength. For a preliminary assessment of the future project of the ship, in terms of permissible design accelerations and the possibility of the ship moving against a sea wave of a certain height, a graph was built based on the application of the energy wave criterion EWC and the requirements of various classification societies.
Assisted Propulsion Device of a Semi-Submersible Ship Based on the Magnus Effect
Authors: Lv Jingze , Lin Yiqun , Zhang Rui , Li Boyang , Yang Hualin
Published: October 2022

The purpose of this study is to explore the potentiality of wind propulsion on semi-submersible ships. A new type of Flettner rotor (two rotating cylinders) system installed on a semi-submersible ship is proposed. The structure and installation of two cylinders with a height of 20 m and a diameter of 14 m are introduced. The numerical simulation of the cylinder is carried out in Fluent software. The influence of apparent wind angle and spin ratio on the two cylinders are analysed, when the distance between two cylinders is 3D-13D (D is cylinder diameter). When the distance between two cylinders is 3D, the performance of the system increases with an increase in spin ratio. Moreover, the apparent wind angle also has an effect on the system performance. Specifically, the thrust contribution of the system at the apparent wind angle of 120° is the largest at the spin ratio of 3.0. The maximum thrust reaches 500 kN. When the spin ratio is 2.5 and the apparent wind angle is 120°, the maximum effective power of the system is 1734 kW. In addition, the influence of the two cylinders distance on system performance cannot be ignored. When the distance between the two cylinders is 7D and the spin ratio is 2.5, the effective power of the system reaches a maximum, which is 1932 kW.