bluuebunny/crossref_metadata_2025 huggingface dataset:
Epigenetic control of early dendritic cell lineage specification by the transcription factor IRF8 in mice
Authors: Kurotaki Daisuke , Kawase Wataru , Sasaki Haruka , Nakabayashi Jun , Nishiyama Akira , Morse Herbert C. , Ozato Keiko , Suzuki Yutaka , Tamura Tomohiko
Published: February 2019

Dendritic cells (DCs), which are vital for immune responses, are derived from bone marrow hematopoietic stem cells via common DC progenitors (CDPs). DC lineage fate decisions occurring at stages much earlier than CDPs have recently been recognized, yet the mechanism remains elusive. By single-cell RNA-sequencing, in vivo cell transfer experiments, and an assay for transposase-accessible chromatin sequencing using wild-type, IRF8-GFP chimera knock-in or IRF8-knockout mice, we demonstrate that IRF8 regulates chromatin at the lymphoid-primed multipotent progenitor (LMPP) stage to induce early commitment toward DCs. A low but significant expression of IRF8, a transcription factor essential for DC and monocyte development, was initiated in a subpopulation within LMPPs. These IRF8+ LMPPs were derived from IRF8– LMPPs and predominantly produced DCs, especially classical DC1s, potentially via known progenitors, such as monocyte-DC progenitors, CDPs, and preclassical DCs. IRF8+ LMPPs did not generate significant numbers of monocytes, neutrophils, or lymphocytes. Although IRF8– and IRF8+ LMPPs displayed very similar global gene expression patterns, the chromatin of enhancers near DC lineage genes was more accessible in IRF8+ LMPPs than in IRF8– LMPPs, an epigenetic change dependent on IRF8. The majority of the genes epigenetically primed by IRF8 were still transcriptionally inactive at the LMPP stage, but were highly expressed in the downstream DC lineage populations such as CDPs. Therefore, early expression of the key transcription factor IRF8 changes chromatin states in otherwise multipotent progenitors, biasing their fate decision toward DCs.
Characteristics of patients with myeloproliferative neoplasms with lymphoma, with or without JAK inhibitor therapy
Authors: Pemmaraju Naveen , Kantarjian Hagop , Nastoupil Loretta , Dupuis Megan , Zhou Lisa , Pierce Sherry , Patel Keyur P. , Masarova Lucia , Cortes Jorge , Verstovsek Srdan
Published: February 2019

There is a Blood Commentary on this article in this issue.
How mRNA therapeutics are entering the monoclonal antibody field
Authors: Van Hoecke Lien , Roose Kenny
Published: February 2019

In 1975, Milstein and Köhler revolutionized the medical world with the development of the hybridoma technique to produce monoclonal antibodies. Since then, monoclonal antibodies have entered almost every branch of biomedical research. Antibodies are now used as frontline therapeutics in highly divergent indications, ranging from autoimmune disease over allergic asthma to cancer. Wider accessibility and implementation of antibody-based therapeutics is however hindered by manufacturing challenges and high development costs inherent to protein-based drugs. For these reasons, alternative ways are being pursued to produce and deliver antibodies more cost-effectively without hampering safety. Over the past decade, messenger RNA (mRNA) based drugs have emerged as a highly appealing new class of biologics that can be used to encode any protein of interest directly in vivo. Whereas current clinical efforts to use mRNA as a drug are mainly situated at the level of prophylactic and therapeutic vaccination, three recent preclinical studies have addressed the feasibility of using mRNA to encode therapeutic antibodies directly in vivo. Here, we highlight the potential of mRNA-based approaches to solve several of the issues associated with antibodies produced and delivered in protein format. Nonetheless, we also identify key hurdles that mRNA-based approaches still need to take to fulfill this potential and ultimately replace the current protein antibody format.
Efficient uncertainty analysis of the 3D electrical tomography inverse problem
Authors: Fernández-Martínez Juan Luis , Fernández-Muñiz Zulima , Xu Shan , Cernea Ana , Sirieix Colette , Riss Joëlle
Published: February 2019

We have evaluated the uncertainty analysis of the 3D electrical tomography inverse problem using model reduction via singular-value decomposition and performed sampling of the nonlinear equivalence region via an explorative member of the particle swarm optimization (PSO) family. The procedure begins with the local inversion of the observed data to find a good resistivity model located in the nonlinear equivalence region. Then, the dimensionality is reduced via the spectral decomposition of the 3D geophysical model. Finally, the exploration of the uncertainty space is performed via an exploratory version of PSO (RR-PSO). This sampling methodology does not prejudge where the initial model comes from as long as this model has a geologic meaning. The 3D subsurface conductivity distribution is arranged as a 2D matrix by ordering the conductivity values contained in a given earth section as a column array and stacking parallel sections as columns of the matrix. There are three basic modes of ordering: mode 1 and mode 2, by using vertical sections in two perpendicular directions, and mode 3, by using horizontal sections. The spectral decomposition is then performed using these three 2D modes. Using this approach, it is possible to sample the uncertainty space of the 3D electrical resistivity inverse problem very efficiently. This methodology is intrinsically parallelizable and could be run for different initial models simultaneously. We found the application to a synthetic data set that is well-known in the literature related to this subject, obtaining a set of surviving geophysical models located in the nonlinear equivalence region that can be used to approximate numerically the posterior distribution of the geophysical model parameters (frequentist approach). Based on these models, it is possible to perform the probabilistic segmentation of the inverse solution found, meanwhile answering geophysical questions with its corresponding uncertainty assessment. This methodology has a general character could be applied to any other 3D nonlinear inverse problems by implementing their corresponding forward model.
An approach for accelerated isolation of genetically manipulated cell clones with reduced clonal variability
Authors: Casden Natania , Behar Oded
Published: February 2019

Genomic editing methods, such as the CRISPR/Cas9 system, are routinely used to study gene function in somatic cells. Owing to the heterogeneity of mutations, it is necessary to purify cell clones grown from high dilution to the point of colony formation, which can be a time-consuming process. Here, we tested a modified approach in which we seeded cells at high dilution, together with non-edited carrier cells. As a comparison, cells were also grown at high dilution with conditioned medium from a high-density culture. When using carrier cells or conditioned medium, the formation of cell colonies is accelerated. Additionally, clones grown with carrier cells are more similar to the parental lines in terms of their tumorigenic properties. Surprisingly, key signaling cascades are highly divergent between clones isolated from low-density cultures, even with conditioned medium, in contrast to clones isolated with carrier cells. Thus, our study uncovers a significant limitation using the common approach of isolating cell clones following genetic modifications and suggests an alternative method that mitigates the problem of heterogeneity of gene expression between clones.

This article has an associated First Person interview with the first author of the paper.
PML is recruited to heterochromatin during S phase and represses DAXX-mediated histone H3.3 chromatin assembly
Authors: Shastrula Prashanth Krishna , Sierra Isabel , Deng Zhong , Keeney Frederick , Hayden James E. , Lieberman Paul M. , Janicki Susan M.
Published: February 2019

The incorporation of the histone H3 variant, H3.3, into chromatin by the H3.3-specific chaperone DAXX and the ATP-dependent chromatin remodeling factor ATRX is a critical mechanism for silencing repetitive DNA. DAXX and ATRX are also components of promyelocytic nuclear bodies (PML-NBs), which have been identified as sites of H3.3 chromatin assembly. Here, we use a transgene array that can be visualized in single living cells to investigate the mechanisms that recruit PML-NB proteins (i.e. PML, DAXX, ATRX, and SUMO-1, SUMO-2 and SUMO-3) to heterochromatin and their functions in H3.3 chromatin assembly. We show that DAXX and PML are recruited to the array through distinct SUMOylation-dependent mechanisms. Additionally, PML is recruited during S phase and its depletion increases H3.3 deposition. Since this effect is abrogated when PML and DAXX are co-depleted, it is likely that PML represses DAXX-mediated H3.3 chromatin assembly. Taken together, these results suggest that, at heterochromatin, PML-NBs coordinate H3.3 chromatin assembly with DNA replication, which has important implications for understanding how transcriptional silencing is established and maintained.
Measurability and reliability of assessments of root length and marginal bone level in cone beam CT and intraoral radiography: a study of adolescents
Authors: Al-Okshi Ayman , Paulsson Liselotte , Rohlin Madeleine , Ebrahim Eman , Lindh Christina
Published: February 2019

Objectives:

To evaluate measurability and reliability of measurements of root length and marginal bone level in CBCT, periapical (PA) and bitewing (BW) radiographs.

Methods:

CBCT of both jaws, PA of maxillary incisors and posterior BW radiographs of 10 adolescents (mean age 13.4) were selected. The radiographs comprised part of the baseline examinations of a trial of orthodontic treatment. Six raters assessed measurability and measured root length and marginal bone level. Three raters repeated their assessments. Measurability was expressed as frequency of interpretable sites and reliability as intraclass correlation coefficient (ICC).

Results:

Measurability was 100 % in CBCT and 95 % in PA of maxillary incisors for root length measurements. For marginal bone level, measurability was 100 % in CBCT, 76 % in PA and 86 % in posterior BW. Mean ICC for interrater reliability for root length measurements in CBCT was 0.88 (range 0.27–0.96 among different teeth) and 0.69 in PA of maxillary incisors. For marginal bone level measurements, mean ICC was 0.4 in CBCT, 0.38 in PA of maxillary incisors and 0.4 in posterior BW. Intrarater reliability varied among methods, root length or marginal bone level and among raters, except for root length measurements in CBCT, which presented high reliability (above 0.8) for all raters.

Conclusions:

As measurability and reliability were high for root length measurements in CBCT, this may be the method of choice for scientific analyses in orthodontics. For clinical praxis, we recommend PA following the “as low as diagnostically acceptable” principle, as clinical decisions seem to be influenced only when severe root resorption occurs.
Oncogenic splicing factor SRSF3 regulates ILF3 alternative splicing to promote cancer cell proliferation and transformation
Authors: Jia Rong , Ajiro Masahiko , Yu Lulu , McCoy Philip , Zheng Zhi-Ming
Published: February 2019

Alternative RNA splicing is an important focus in molecular and clinical oncology. We report here that SRSF3 regulates alternative RNA splicing of interleukin enhancer binding factor 3 (ILF3) and production of this double-strand RNA-binding protein. An increased coexpression of ILF3 isoforms and SRSF3 was found in various types of cancers. ILF3 isoform-1 and isoform-2 promote cell proliferation and transformation. Tumor cells with reduced SRSF3 expression produce aberrant isoform-5 and -7 of ILF3. By binding to RNA sequence motifs, SRSF3 regulates the production of various ILF3 isoforms by exclusion/inclusion of ILF3 exon 18 or by selection of an alternative 3′ splice site within exon 18. ILF3 isoform-5 and isoform-7 suppress tumor cell proliferation and the isoform-7 induces cell apoptosis. Our data indicate that ILF3 isoform-1 and isoform-2 are two critical factors for cell proliferation and transformation. The increased SRSF3 expression in cancer cells plays an important role in maintaining the steady status of ILF3 isoform-1 and isoform-2.
Intellectual property: Literary property
Authors: Кулешова Инна , Kuleshova Inna , Рахматулина Римма , Rahmatulina Rimma , Рузакова Ольга , Ruzakova Ol'ga , Ручкина Гульнара , Ruchkina Gul'nara , Свиридова Екатерина , Sviridova Ekaterina
Published: February 2019

The textbook is devoted to questions of art property. He contains the analysis of general provisions of intellectual property right, a concept of results of intellectual activity, the intellectual rights and their types. The questions concerning copyright including copyright sources, a concept and contents of copyright, subjects of copyright, free use of subjects of copyright, the rights for the computer programs and databases, subjects of copyright are in detail considered and also I am right, adjacent to copyright. For the best digestion of material each chapter of the textbook comes to the end with a practical work which includes the thesaurus, control questions and tasks praktiko-focused and test tasks, the list of the recommended sources.
Conforms to requirements of the Federal state educational standard of the higher education of the last generation.
The textbook is intended for use in educational process in the direction of preparation 40.03.01 "Law" (bachelor degree level) in Federal public educational budgetary institution of the higher education "Financial University under the Government of the Russian Federation" and also in the legal educational organizations of the higher education.
Crowdfunding and the Democratization of Access to Capital—An Illusion? Evidence from Housing Prices
Authors: Kim Keongtae , Hann Il-Horn
Published: February 2019

Access to finance is arguably one of the most critical challenges in starting a new business. And people say that crowdfunding has the potential to democratize access to finance. In this study, we examine whether crowdfunding democratizes access to finance and, if so, how. To examine this, we obtained data on housing prices related closely to the cost of accessing bank loans and matched these data to a 2009–2013 novel data set from a leading crowdfunding market. We find an increased decline in housing prices leads to a significant increase in the creation of crowdfunding projects. However, we did not find significant differential effects in housing price changes between successful and unsuccessful projects. Finally, the effect of housing prices on crowdfunding projects was more significant for areas with low socioeconomic status. Interestingly, the increase in crowdfunding projects in these low-status areas was driven wholly by a significant increase in unsuccessful projects, whereas the effect of housing prices on successful projects was significant only in areas of high socioeconomic status. Overall, our study suggests that crowdfunding can supplement traditional sources of funding although socioeconomic status may still prevent disadvantaged people from receiving its full benefits.
Islamophobic violence as a form of gender-based violence: a qualitative study with Muslim women in Canada
Authors: Ahmad Sidrah Maysoon
Published: February 2019

This paper represents the first empirical qualitative research study on Islamophobic violence against Muslim women in the Canadian context, and presents a novel characterisation of Islamophobic violence against Muslim women as a form of gender-based violence. Twenty-one Muslim women in Toronto and its surrounding areas were interviewed regarding their encounters with Islamophobic violence: they disclosed over 30 incidents, only three of which were reported to police. The spectrum of Islamophobic violence disclosed by participants includes attempted femicide, physical assault, sexual assault and verbal assault. Moreover, two participants disclosed situations of intimate partner violence (IPV) that were entangled with Islamophobic abuse, representing a hitherto uncharacterised intersection of Islamophobia and IPV in the Canadian context. All incidents of physical and sexual violence disclosed by participants were said to have been perpetrated by white men. Many participants believed that they were targeted for Islamophobic violence because of the impact of gendered Islamophobic discourses that construct Muslim women as being passive, weak and oppressed – and therefore as ‘acceptable targets’ for violence. I offer the novel term ‘Islamophobic gender-based violence’ in order accurately name the reality of violence that Muslim women face in the nexus of misogyny and Islamophobia.
Ecosistemas para el emprendimiento: Características del concepto y su aplicación a la empresa social
Authors: Torres Ortega Jorge Antonio
Published: February 2019

Las distintas aproximaciones que hacen uso del concepto biológico de ecosistema para abordar el fenómeno del emprendimiento subrayan la necesidad de capturar de manera holística todos los factores ambientales que contribuyen al éxito o fracaso de los emprendedores. Si bien este enfoque ha venido ganando una aceptación cada vez mayor entre académicos y policy makers, no puede afirmarse que exista un consenso en cuanto al significado exacto del constructo ecosistema para el emprendimiento. El presente artículo tiene como objetivo principal evaluar las similitudes y diferencias presentes en las distintas versiones del enfoque ecosistémico, con énfasis en el emprendimiento social. Se advierte que, aunque existen premisas comunes, los distintos modelos de ecosistema para el emprendimiento se diferencian en cuanto a los factores que destacan como condicionantes del surgimiento y permanencia de las iniciativas emprendedoras. En el caso del emprendimiento social, dichas diferencias tienen importantes implicaciones de carácter práctico.
Enplegu banaketaren esperientzia krisian: gipuzkoako kasua, gizarte ekonomia azpimarratuz
Authors: Mugarra-Elorriaga Aitziber , Echaniz-Barrondo Arantza , Enciso-Santocildes Marta , Serrano-Argüeso Mariola , Gómez-Urquijo Laura , Blanco-Meruelo Elena , Ereñaga-DeJesús Nerea
Published: February 2019

Krisian lan egiteko aukeren banaketa desorekatua denez, enplegua banatzeko neurriak planteatzen dira lan egiteko benetako aukerak modu orekatuan birbana-tzeko lanpostu eske dabiltzan pertsona guztien artean. Horrek berekin dakar: lan denbora berrantolatzea, lana beste era batera banatzeko; lan denbora berri horre-tara langile gehiago egokitzea; enpleguaren eta soldaten kalitatea bermatzea; eta langileen bizi kalitatea eta ongizatea babestea. Egungo egoeran, bi neurri mota ezagutzen ditugu lanaren banaketan laguntzen dutenak: Alde batetik, banaketa huts-hutseko neurriak, enplegua sortzen dutenak. Eta beste aldetik dagoen en-plegua mantentzeko balio duten banaketa neurriak, eta guzti horiek lau sail nagu-sitan sailkatuta agertzen dira guk diseinatutako Enplegu banatzeko neurrien ma-pan. Artikulu honetan azaltzen ditugu zeintzuk dira neurri horiek eta nola aplikatu dira 2008tik 2014raino Gipuzkoako erakundeetan, azpimarratzen gizarte ekono-miaren kasua eta generoaren ikuspuntua.
Las cooperativas ante un nuevo ciclo de transformaciones. Su contribución a los retos del tejido productivo vasco
Authors: Ortega Igor
Published: February 2019

La economía vasca y el tejido empresarial del territorio enfrentan un contexto de grandes transformaciones caracterizado por la eclosión de las economías emergentes y por la apuesta de las economías avanzadas por la industria de alta tecnología y los sistemas regionales de innovación. En el presente artículo, utilizando diversas fuentes estadísticas, se analiza la contribución que en este escenario realizan las cooperativas en relación al resto de modelos de empresa. El análisis identifica el importante rol que asumen las cooperativas no solo en cuanto a su capacidad de resiliencia sino también en cuanto a coliderar el proceso de transición de la economía vasca hacia un modelo de desarrollo sostenido sobre la base de un tejido industrial innovador y tecnológicamente avanzado.
Local Beef Cattle Breeding Program in Indonesia
Authors: Romjali Endang
Published: February 2019

Indonesia has a number of cattle breeds that have certain advantages as meat-producing cattle with high adaptability to the local environment. Local beef cattle breeding has now been carried out by the government through technical implementation unit. Efforts to build local cattle breeding still need to be improved to be able to meet sustainably the demands of local cattle breeding stocks for the farmers. However, beef cattle breeding business is less attractive to investors because it is economically less profitable and requires a long maintenance time compared to the fattening business. This paper aims to provide an overview of thoughts in an effort to improve the performance of local beef cattle breeding in Indonesia. In supporting the local cattle breeding program, the role of central and regional governments still has to be dominant mainly in the establishing of breeding centers as the core and policies related to the operationalization of activities involving farmers and other stakeholders.
Pemeringkatan obligasi industri perbankan di Bursa Efek Indonesia berdasarkan kinerja keuangan bank
Authors: Arpadika Rohyawati Sholihin , Lutfi Lutfi
Published: February 2019

The purpose of this study is to analyse the influence of financial performance toward bond rating of banking industry in the Indonesia Stock Exchange. The financial performance variables examined in this study include liquidity, profitability, capitalization, and asset quality. The Sample was selected using purposive sampling method. Populations of this research were taken from the banks, listed in Indonesia Stock Exchange in 2011-2015. The total population was 42 banks and only 10 of them meet the criteria. The data were analyzed using multiple regression analysis to test the hypothesis. The results of the research show that profitability has a positive influence to the bond rating, while liquidity, capitalization, and asset quality has a negative influence to the bond rating. This study imply that banks need to improve their profitabilities while maintaining their liquity risk, capital level and asset quality in order to enhance their bond ratings.
Pengaruh literasi keuangan, experienced regret, risk tolerance, dan motivasi pada keputusan investasi keluarga dalam perspektif masyarakat Bali
Authors: Wardani Astri Kusuma , Lutfi Lutfi
Published: February 2019

This study aims to determine the effect of financial literacy, experienced regret, risk tolerance, and motivation on family investment decisions by taking samples of 105 Balinese residents. The investment decision investigated in this study is dealt with the decision to invest the money in capital market instruments and bank accounts. The analytical method used is a quantitative method using multiple linear regressions. The data were collected using a survey of questionnaire to the respondent. The sampling technique used is purposive sampling method and then continued using convenience sampling. The results of this study indicate that risk tolerance has positive influence on investment decisions of Balinese family. Meanwhile, financial literacy, experienced regret, and motivation do not affect significantly investment decisions of Balinese family. These results imply that Balinese people consider their risk tolerance as the main factor considered in making decision whether to put the money in bank accounts or capital market instruments.
Causes of delays in budget absorption as the development of good governance on deconcentration and co-administration task budget (A case study at the work unit of DKP-NTB Province)
Authors: Wadi Muhamad Ichsan , Herawati Rr. Titiek , Husnan L. Hamdani
Published: February 2019

The objective of study is to determine the causes of delays in the absorption of De-concentration (Decon) and Co-administration Task (TP) budget at the level of Work Unit. In carrying out its function as an agent of the Ministry of Maritime Affairs and Fisheries (DKP). The Work Unit has developed operational plan, nevertheless it plan could not be followed up. Such condition surely has consequences on the budget absorption at the Work Unit. This study is a qualitative study using a case study approach. The study uses a holis-tic single case study. The results indicate that there are many obstacles encountered by the Work Unit in carrying out its daily activities related to budget absorption. The obstacles may be from internal factors and external factors. The strong intervention of principal in Decon and TP budget is a key issue of the external factor that makes the Work Unit unable to be consistent to the operational plan drawn up. Besides, the procurement of goods and services through the Procurement Services Unit is also an obstacle for the Work Unit in executing the work using tender mechanism. Other external factors are the mechanisms of Money Supply (UP) and the Change of Money Supply (GUP) that cause the Work Unit to get difficulty in setting up funds for activities. Meanwhile, the internal factors that con-strain the Work Unit are issues concerning Human Resources, Standard Operating Proce-dures and Performance Evaluation that have not been implemented well in the internal Work Unit. The theoretical implication of the study is the dominant intervention of the principal (central government) to the agent (Work Unit) is a resistance to the implementa-tion of the values of effectiveness and efficiency in the concept of good governance.
ICU auditorsâ€Ÿ understanding of achieving good university governance
Authors: Ahmad Arisona , Djamhuri Ali , Kamayanti Ari
Published: February 2019

This study aims to determine the Internal Control Unit (ICU) auditorsâ€™ under-standing in achieving Good University Governance (GUG) at Jember University (UNEJ). This study uses interpretive phenomenology. Method of data collection is conducted by interviewing the ICU auditors of UNEJ. The research findings indi-cate that the ICU auditorsâ€™ understanding in carrying out their function is com-pliant with the ICU charter. Through in-depth interview with informants, it is found noesis, in which the informantsâ€™ understanding is not only through the know-ledge and implementation of the existing rules, but also through cultural practices of "mutual support". For Jember University, the ICU plays a critical role in achiev-ing GUG by fixing the governance of the work unit related to non-academic fields that include finance, human resources, goods and services procurement, and public asset management.
The effect of participatory budgeting on the performance of government officials (An empirical study in West Lombok District)
Authors: Fachrizal Mohammad , Suparman Lalu , . Animah
Published: February 2019

This study aimed to examine effects of three intervening variable directly and indirectly, that are job relevant information, budget goal commitment, and job satisfaction on relationship between budgetary participation and apparatus performance. The inconsistencies of the previous research of the effect of the budgetary participation on the performance become the motivation of the present research. The present research is a survey in which data were collected using a questionnaire distributed to the SKPD Structural Officials of consisting of Echelon II, Echelon III and Echelon IV at the Regional Government of West Lombok Regency. The populations are 673 persons structural officials of Echelon II, Echelon III and Echelon IV. Respondents was selected by purposive sampling method in which officers involved in the budgeting process, of the 122 distributed questionnaires, all questionnaires were returned. The analysis method was variant-based SEM using SmartPLS Version 2.0 M3. The instruments have been examined for its validity and reliability. The results show that the budgetary participation has influence with the apparatus performance but not significant, the budgetary participation has significant effect on job relevant information, job relevant information has significant effect on the apparatus performance, budgetary participation has significant effect on budget goal commitment, budget goal commitment has significant effect on the apparatus performance, budgetary participation has significant effect on job satisfaction, and job satisfaction has significant effect on the apparatus performance. The research could prove the budgetary participation has correlation with the apparatus performance through job relevant information, budget goal commitment, and job satisfaction. The implication of this research that the increased performance of the apparatus can be done by increasing the budgetary participation through job relevant information, budget goal commitment, and job satisfaction.
Determinant of the presentation of proxy of user assets report and its implication for the quality of financial statements (A case study at the Work Unit of KPPN Mataram)
Authors: Slamet Triko , . Busaini , Fitriyah Nur
Published: February 2019

The purpose of this study is to determine the effect of human resource ability, information technology utilization, government internal control system, and organizational commit-ment towards the presentation of proxy of user assets report and the effect of the presenta-tion of proxy of user assets report on the quality of financial statement. The population consisted of the providers of proxy of user assets report and the providers of financial state-ments at the Work Unit of State Treasury Service Office (KPPN) Mataram as many as 726 people with a total sample of 88 people. This study uses four exogenous variables: human resource ability, information technology utilization, government internal control system, organizational commitment, and two endogenous variables: the presentation of proxy of user assets report and the quality of financial statements. Data collection technique used in this study is a survey by distributing questionnaires. Data analysis tool used is SmartPLS version 2.0 M3. The results show that the human resource ability and government internal control system have positive influence on the presentation of proxy of user assets report, information technology utilization and organizational commitment have no influence on the presentation of proxy of user assets report, and the presentation of proxy of user assets report has positive influence on the quality of financial statements.
The effect of firm size, financial performance, listing age and audit quality on Internet Financial Reporting
Authors: Mahendri Ni Wayan Putri , Irwandi Soni Agus
Published: February 2019

Financial reporting is the most important information for investors. So far, a rapid internet growth has created a new strategy for companies to communicate with investors. In this case, internet could be used by companies to report their financial information, or commonly known as Internet Financial Reporting (IFR). The objec-tive of this study is to analyze the effect of firm size, profitability, liquidity, leverage, listing age, and auditor reputation on Internet Financial Reporting. The sample, as based on sampling criteria, consists of 82 manufacturing companies listed in the Indonesia Stock Exchange in 2013. This study used a multiple regression analysis for the analyses such as to examine the variables that affect the Internet Financial Reporting. The findings show that firm size has a significant effect on Internet Fi-nancial Reporting. However, other factors such as profitability, liquidity, leverage, listing age, and auditor reputation have no significant effects on Internet Financial Reporting. The implication of this study is that the investors can use this study as a reference related to investment in Indonesia.
The Role of Trust as an Informal Mechanism in the Management Control System of Performance Effectiveness
Authors: Yandra Fachmi Pachlevi
Published: February 2019

Performance is a variable explaining the effectiveness of internal control systems that managed based on management accounting information and functions. There are some aspects of behavior that remain unexplained in understanding the effectiveness of the performance of organizations and individuals affected by the data and accounting functions. In addition, social mechanisms such as culture, honesty, group identification and trust play an important role in mitigating agency problems. This study aims to investigate what and how the role of trust in organizational performance is. It develops and tests a conceptual relation model between trust and performance through organizational commitment and job satisfaction. It also examines contextual factors in the form of cognitive orientation of the conceptual model that has been built. The data were collected by using questionnaire-based survey method for the employees based on the criteria of having direct supervisors and directly responsible for them, and a minimum work period of one year. They were analyzed using SEM PLS. It shows that organizational commitment mediates the positive relationship between trust and job satisfaction. The positive relationship between trust and performance is mediated by organizational commitment and job satisfaction. It also shows that cognitive orientation influences the relationship between job satisfaction and performance. This study contributes to the management accounting literature, that is, a conceptual relationship model of trust to performance in the realm of empirical research
An Investigation of the Theory of Planned Behavior and the Role of Tax Amnesty in Tax Compliance
Authors: Novianti Agnes Findia , Uswati Dewi Nurul Hasanah
Published: February 2019

The individual taxpayersâ€™ low awareness has become the main problem of developing countries in tax aspect. Thus, this study aimed to examine the determinant factors of tax noncompliance using Ajzenâ€™s (1991) Theory of Planned Behavior as a theoretical framework. Specifically, Tax Amnesty is added to the theoryâ€™s constructs: attitude, subjective norms, and perceived behavioral control. Tax Amnesty is expected to be a moderating influence. The population of this study is individual taxpayer in KPP Pratama Sukomanunggal. Based on convenience sampling method, the number of sample in this study are 145 samples. The data was analyzed using Structural Equation Modeling (SEM) with SmartPLS.3.0 and SPSS 21. The results indicated that first, attitude and subjective norms are significantly influence behavioral intention except perceived behavioral control. Second, the model including Tax Amnesty provides a significant influence of tax noncompliance in two constructs; attitude and subjective norms. However, the interaction effect of perceived behavioral control does not appear significantly.
Pemanfaatan E-Journal oleh Mahasiswa pada Perpustakaan Perguruan Tinggi di Jakarta
Authors: Wicaksono Hendra
Published: February 2019

Penelitian ini menganalisis pemanfaatan ejournal oleh mahasiswa pada perguruan tinggi di Jakarta. Penelitian ini menggunakan pendekatan kuantitatif dengan menggunakan metode diskriptif. Pengumpulan data dilakukan dengan penyebaran kuesioner, observasi, dan wawancara. Penelitian dilakukan dengan cara penyebaran kuesioner pada 122 responden berisi 19 butir pertanyaan pada mahasiswa dan pustakawan disertai dengan wawancara. Proses terakhir peneliti melakukan analisis data yang sudah di olah menggunakan software Microsoft Excel 2013. Data yang telah diolah, dianalisis menggunakan skala likert berdasarkan teori SWOT strength (Kekuatan), Weakness (Kelemahan), Oppurtinities (Peluang), dan Threats (ancaman) . Hasil penelitian menunjukkan bahwa  mayoritas responden menjawab positif tentang fasilitas E-Journal yang dilanggan namun sebagian kecil responden menjawab sering kesulitan dalam memanfaatkan E-Journal . Kesulitan ini terjadi karena tidak mengetahui bahwa E-Journal yang disediakan oleh perpustakaan dapat diakses dari rumah. Maka dapat dilihat bahwa mahasiswa sangat antusias terhadap fasilitas E-Journal yang dilanggan. Kemudian dari pertanyaan tentang layanan ejournal di perpustakaan, dapat dilihat bahwa mahasiswa menilai layanan E-Journal yang dilanggan cukup baik.
Kolaborasi dan Produktivitas Penulis pada Prosiding Lokakarya Nasional Dokumentasi dan Informasi PDII LIPI Periode 2013-2017
Authors: Rahayu Rochani Nani , Tupan Tupan
Published: February 2019

Prosiding Lokakarya Nasional  Dokumentasi dan Informasi  periode 2013 – 2017 dikaji dengan metode bibliometrik untuk mengetahui ; 1) Jumlah artikel; 2) Pola kepengarangan; 3) Derajat kolaborasi; 4) Produktivitas penulis. Hasil penelitian menunjukkan bahwa : 1) jumlah artikel sebanyak  66 judul  dengan jumlah penulis 101 orang; 2) Pola kepengarangan yang diteliti menunjukkan bahwa artikel terbanyak ditulis oleh penulis tunggal yaitu sebanyak 42 artikel (63,64%),  disusul oleh dua penulis sebanyak 14 artikel (21,21%),  tiga penulis sebanyak 6 artikel (9,09%), empat penulis 3 artikel (4,55% ), tidak dijumpai penulis yang berkolaborasi secara berlima,  dan 6 penulis 1 artikel (1,51%); 3) Nilai derajat kolaborasi dijumpai sebesar 0,39 dan 4) Dijumpai 10 orang penulis paling produktif menulis 2 judul artikel dengan jumlah yaitu Ambar Yoganingrum, Dwi Ridho Aulia, Heri Abi Burachman Hakim, Himawanto, Madiareni Sulaiman, Putu Laxman Pendit, Rulina Rachmawati, Sadjuga, Tupan dan Wahid Nashihuddin, dan rata – rata penulis/ artkel adalah 1,53.  Kesimpulan penelitian adalah bahwa kolaborasi penulis dalam Prosiding Lokakarya Dokumentasi dan Informasi periode 2013 – 2017 masih rendah, karena artikel masih didominasi oleh penulis tunggal. Hal tersebut diperkuat dengan nilai derajat kolaborasi yang rendah, dan  produktivitas penulis juga rendah karena tidak ada penulis  yang menulis lebih dari 2 artikel.
Pengaruh Panjang dan Diameter Stud terhadap Keruntuhan Geser Struktur Komposit Baja-Beton
Authors: Ayu Hapsari Rahma Nindya , Nurhuda Ilham , Nuroji Nuroji
Published: February 2019

Composite structures of concrete slabs and steel beams require shear connectors to transfer shear force between steel beams and concrete slabs. The strength of stud shear connector specified on SNI 03-1729-2013 only considers the effect of stud diameter, however the length of a stud may influence its behavior and strength. This research observes the effects of length and diameter (𝓁/𝒹) of shear connectors on the strength. This research was conducted using the push out method explain in AS-4347- Part I. The test specimens observed in this research were concrete and steel composites, composing IWF 350x175x11x14 mm and concrete blocks of size 450x225x160 mm. The studs were made of steel reinforcements with diameter (𝒹) of 10, 16 and 22 mm, were welded on IWF with 5 mm weld thickness. The length of studs for each stud diameter were 4d, 5d, and 6d. The results indicate that the increase in stud diameter will increase the load capacity of stud. The length of studs effect its load capacity. A slim stud experiences large bending moment at the base of the shear connector. The results show that the highest value of load capacity is measured at specimens with 𝓁/𝒹 ratio of 5.
Evaluasi Tingkat Akurasi Digital Elevation Model (DEM) SRTM dan ASTER GDEM dalam Pemodelan Daerah Aliran Sungai (DAS) Ciliwung
Authors: Sutisna Ade Suhendar , Putro Haryono
Published: February 2019

Availability of Digital Elevation Model (DEM) dataset and Geographic Information System (GIS), makes the watershed properties can be extracted automatically. There are two DEM providers which are freely accessible for research purposes and commonly use that is the Shuttle Radar Topographic Mission (SRTM) - DEM (30m) and Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) Global Digital Elevation Model Version 2 (GDEM V2). Based on the result of modeling conducted at Ciliwung River Basin with Qgis application, area generated from SRTM data is 5% smaller than Ciliwung River Basin which obtained from BPDAS Ciliwung-Citarum as a reference, while the result of ASTER-GDEM data is 87% larger than reference. Linear Regression Test and t-Test performed on three segments of the watershed shows that the upstream of both samples gives a good accuracy result that is R2 = 0,999; P = 0,499 (SRTM) and R2 = 0,999; P = 0,481 (ASTER-GDEM), while in the middle and downstream segments respectively for both samples are SRTM with R2 = 0,993; P = 0,413 and R2 = 0,734; P = 0,088; and then ASTER-GDEM with R2 = 0,784; P = 0,00038 and R2 = 0,376; P = 1,27209 x10-22.
Analisis Pengaruh Fluktuasi Muka Air Waduk terhadap Stabilitas Lereng Waduk Dengan Menggunakan Program Plaxis 2D
Authors: Wulandari Paravita Sri , Tjandra Daniel
Published: February 2019

Reservoir is needed as a source of water supply to the surrounding populations. The design of a reservoir needs to consider several aspects of soil embankment such as variations in water content and changes in shear soil shear strength and also the influence of water level in reservoir. The purpose of this research is to analyze these three aspects in the design of a reservoir. This research was begun by taking soil samples for embankment and conducting soil tests to obtain soil characteristics at the initial condition. The further laboratory tests were conducted to determine the effect of changes in water content on the shear strength of the soil. The variation of soil embankment characteristic was then modeled by Plaxis 2D program to obtain the effect of changes in soil embankment characteristic and fluctuation of the water level in the reservoir. The results showed that the increase in water content significantly decrease the shear strength of the soil. The changes of soil shear strength affect the pattern of slope failure and safety factor. In addition, the pattern and direction of the slope failure were also influenced by the water level of the reservoir.
Analisa Pushover dan Eksperimen Struktur Portal dengan Dinding Batubata dengan Menggunakan Angkur pada Kolom dan Balok pada Non Engineered Building
Authors: Hutajulu Marsaulina , Tarigan Johannes , Tarigan Perwira
Published: February 2019

Based on the findings in almost all earthquakes that hit Indonesia, buildings that were damaged and collapsed were simple non-engineered buildings. Where buildings are built based on practical experience without structural calculations. One form of damage to non-structural components and structures is the relationship between columns and brick walls, where cracks and separation between columns and walls occur due to lack of anchors (cuttings). To find out how much an earthquake load can make a test object that uses anchor has been destroyed, a pushover analysis is carried out numerically and experimentally. From the numerical results it is obtained a pushover of 7490 kg and a displacement of 16.7 mm, while the experimental results obtained a pushover 7,540 kg and 56.5 mm displacement. Numerical results and experiments are very close at 99.34%.
Biodiesel Production from Waste Cooking Oil Purified with Activated Charcoal of Salak Peel
Authors: Buchori Luqman , Ubay Dinda Labibah , Syahidah Khonsa
Published: February 2019

Biodiesel is one of diesel fuel alternative made from renewable resources such as vegetable oils and animal fats. One of the natural ingredients that can be used as a material in the production of biodiesel is waste cooking oil (WCO). Biodiesel from WCO can be made through a transesterification reaction using a CaO catalyst. Free fatty acid (FFA) content in WCO needs to be reduced by activated charcoal adsorption. This research aims to determine the optimum time of adsorption by activated charcoal that made from salak peel and to determine the effect of transesterification temperature on biodiesel yield. The results showed that the FFA content of WCO decrease from 6.16% to 0.224% with adsorption time is 80 minutes and 10 gram of activated charcoal. Biodiesel yield increase by increasing transesterification temperature. The appropriate temperature is 50oC with 86.40% of yield, 887.2 kg/m3of density, 5.174 mm2/s of kinematic viscosity and acid number 0.421 mg KOH/gram sample. The composition of alkyl ester was obtained 65.54% with a FAAE yield of 56.63%.
Front Matter
Authors: Widayat W
Published: February 2019

bagian depan reaktor
Coronin 1A deficiency identified by newborn screening for severe combined immunodeficiency
Authors: Dinur Schejter Yael , Mandola Amarilla , Merico Daniele , Reid Brenda
Published: February 2019

Introduction: Coronin 1A belongs to a large family of actin regulatory proteins with a role in T cell homeostasis. A role for coronin 1A was also observed in macrophages, NK, and neuronal cells. To date, coronin 1A deficiency has been described in relatively few patients with combined immunodeficiency.

Aim: We studied here the molecular and genetic basis of immunodeficiency detected by newborn screening for severe combined immunodeficiency.

Methods: Patient data was collected in accordance with REB approved protocols. Immune work up, including T and B cell proliferative responses and serum concentrations of immunoglobulins, was performed. Next generation sequencing techniques and cellular analyses were also utilized.

Results: The patient presented with T cell lymphopenia, reduction in CD4+CD45Ra+ cells and hypogammaglobulinemia. Uniquely, she also had persistent severe neutropenia. Whole exome sequencing and Sanger confirmation revealed a novel homozygous mutation in coronin 1A.

Conclusion: Coronin 1A deficiency can be detected after birth by T cell receptor excision circle-based newborn screening.

Statement of novelty: We report here a patient with a novel mutation in coronin 1A, identified during newborn screening with low T cell receptor excision circle levels and neutropenia, which is a unique finding in this condition.
Cross-industry growth differences with asymmetric industries and endogenous market structure
Authors: Huang Chien-Yu , Ji Lei
Published: February 2019

We develop a two-industry R&D growth model with a free-entry endogenous market structure to evaluate the impact of industrial fundamentals on cross-industry differences of TFP growth and R&D intensity. Endogenous market structure in our model allows the firm’s market size to respond to the firm’s entry and exit which complements the models with an exogenous market structure in the previous literature. We find that surprisingly, an industry with a relatively high R&D productivity or appropriability exhibits “relatively” low in-house innovation growth and R&D intensity during transition. Moreoever, we examine the effects of R&D subsidies and patent breadth policies on industry differences by implementing both asymmetric and symmetric policy rules. We find that only asymmetric R&D subsidies have impacts on TFP growth and R&D intensity differences.
A global random walk on spheres algorithm for transient heat equation and some extensions
Authors: Sabelfeld Karl K.
Published: February 2019

We suggest in this paper a global Random Walk on Spheres (gRWS) method for solving transient boundary value problems, which, in contrast to the classical RWS method, calculates the solution in any desired family of m prescribed points.
The method uses only N trajectories in contrast to mN trajectories in the conventional RWS algorithm.
The idea is based on the symmetry property of the Green function and a double randomization approach.
We present the gRWS method for the heat equation with arbitrary initial and boundary conditions, and the Laplace equation.
Detailed description is given for 3D problems; the 2D problems can be treated analogously.
Further extensions to advection-diffusion-reaction equations will be presented in a forthcoming paper.