bluuebunny/crossref_metadata_2025 huggingface dataset:
Kherzet Youcef Mine Flooding of 2nd June 1990 Revisited (Northeastern of Algeria) Origine and Hydrogeological Consequences
Authors: Souhila CHEDDAD , Abdelhamid Haouchine
Published: November 2021

This work is part of the hydro geological study of the Kherzet Youcef deposit. The polymetallic deposit of Kherzet Youcef is known since the beginning of the 20th century. It is known by the exploitation of Lead and Zinc ore. It is located 50 Km southeast of Setif (North-eastern Algeria) and 5.5 Km west of Ain Azel. Mineralization can be described by some ore bodies (about 25). The thickness variate from a few centimeters up to 3 m. These bodies are located on the layers of dolomite and dolomitized marl and along the Kherzet Youcef fault. The geological reserves of Zinc and Lead ore are of the order of 1.6 million tons. This ore has a Pb content of 3.6% and Zn content of 18.4%. The projected annual exploitation was 100 thousand tons per year. Hydro geological studies carried out successively (1973-1977) and (1981-1983) revealed the existence of an aquifer system located west of the Kherzet Youssef fault. It is characterized by the presence of Karts and by strong cracking due to local brittle tectonics. These two characteristics define the filtration and storage capacity of very abundant groundwater. This groundwater represented a major handicap for mining in view of the large amounts of water that required the installation of major pumping and drainage devices. The Kherzet Youssef mine has experienced frequent flooding in the past at a time when technology could not pump efficiently. It caused the mine to close several times. In June 1990, the mine experienced a flood of great magnitude that has never been observed and despite the large installed means of pumping, this 'water costled to the total drowning of the mine, the death of 19 workers and the stoppage of the exploitation of this deposit since. Pitting attempts were carried out with a pumping capacity of 1100 m3/h, then 1800 m3/h but without success. The interpretation of the drawdown data and field observations made it possible to conclude that this accident was only the result of the general destabilization of the massif. Our complementary work by geophysical prospecting made it possible to represent the configuration of the underground layers and demonstrate the hydrodynamic communication between the two East and West compartments of the deposit.
Global Mean Sea Level Variation On Interannual-Decadal Timescales: Climatic Connections
Authors: Liao Jennifer Ting-Juan , Chao Benjamin Fong
Published: November 2021

We investigate the influences of the climatic oscillations on global mean sea level (GMSL) on interannual-decadal timescales. We conduct correlation analyses on the GMSL-ID time series, which is obtained upon removing numerically the long-term trend and seasonal variations from satellite radar altimeter data since 1992, with several climatic oscillations represented by their respective meteorological indices, including El Niño-Southern Oscillation (ENSO), Pacific Decadal Oscillation (PDO), Atlantic Multidecadal Oscillation (AMO), Arctic Oscillation (AO), Antarctic Oscillation (AAO). From the time-domain correlation and frequency-domain coherence, we find: (i) High correlation between GMSL and ENSO on timescales longer than 1.5 years, especially w.r.t. the Central-Pacific type of El Niño, evidently related to changes in dynamics of the ocean mixed layer and in land-sea distribution of precipitation. (ii) Moderate correlations of GMSL with PDO and AMO, respectively on timescales of over 4 years and 2-10 years, where AMO’s correlation peaks at 8 months earlier in phase than GMSL. (iii) Weak correlation of GMSL with AO implying exchanges of the Arctic water with other oceans even though the altimetry data do not include Arctic sea,. (iv) Practically no correlation between GMSL and AAO. Finally, we least-squares fit the above five indexes to GMSL to assess the relative contribution of each oscillation in causing the interannual GMSL variations, which would lead to a better understanding of the GMSL under the on-going climate changes.
Assessment of Renewable Electricity Policy for Sustainable Electricity Generation in Nigeria
Authors: IYABO OLANRELE
Published: November 2021

Nigeria commits to fast track the integration of renewables in electricity generation by enacting a 2015 National Renewable Energy and Energy Efficiency Policy (NREEEP). Thus, this policy briefing assesses the effect of the policy, and other socioeconomic factors, on the deployment of renewable electricity generation. The preliminary findings show that renewable energy policy has little effect in facilitating renewable electricity integration in Nigeria due to lack of political will and its adverse effect evident in the non-implementation of incentives like feed-in-tariffs and a zero import duty waiver. Second, increased fossil fuel consumption impedes the deployment of renewable electricity due to the hydrocarbon endowment and its subsidization. The domestic financial market development in Nigeria does not also support the deployment of renewable electricity that requires long-term finance. It requires a political will to strengthen the legal and institutional framework for a sustainable electricity generation deployment. It is also pertinent to consider the total removal of fossil fuel subsidies for renewable electricity integration.
Achieving Energy Justice in Malawi: From key Challenges to Policy Recommendations
Authors: McCauley Darren , Grant Rebecca , Mwathunga Evance
Published: November 2021

Addressing energy provision and access in Sub-Saharan Africa is a key global challenge. This paper builds a deep understanding of how fair and just energy policies and realties are in this context. It qualitatively assesses the perceptions of stakeholders in Malawi, where electricity access remains amongst the lowest in the region. Insufficient and unreliable systems of grid energy generation and distribution limit access to electricity in both urban and rural settings. Using wood fuel remains high for meeting cooking, heating, and lighting needs. Responding to these dual challenges, of lacking electricity access and ongoing wood fuel use, must be rooted in notions of equity, fairness, and justice. This paper argues that energy justice provides key insights into how best to respond to complex and interconnected issues of energy generation and access in low-income settings. Drawing on interviews with key stakeholders in policy and Malawi on addressing these challenges, this paper also outlines recommendations for policy. Overall, a just response to these energy challenges is possible, but only if it is built on local inclusive governance with fairer and effective systems of investment.
Plant Community Analysis Along Environmental Gradients In Moist Afromontane Forest of Gerba Dima, South-Western Ethiopia
Authors: Dibaba Abyot , Soromessa Teshome , Warkineh Bikila
Published: November 2021

Background: This study was carried out in Gerba Dima Forest, South-Western Ethiopia, to determine the floristic composition, species diversity and community types along environmental gradients. Ninety sample plots having a size of 25 X 25m (625m2) were laid by employing stratified random sampling. Nested plots were used to sample plants of different sizes and different environmental variables. All woody plant species with Diameter at breast height (DBH) ≥ 2.5 cm and height ≥ 1.5m were recorded in 25 m X 25 m plots. Hierarchical (agglomerative) cluster analysis was performed using the free statistical software R version 3.6.1 using package cluster to classify the vegetation into plant community types. Redundancy Analysis (RDA) ordination was used in describing the pattern of plant communities along an environmental gradient. Result: One hundred and eighty plant species belonging to 145 genera, 69 families and comprising of 15 endemic species were recorded. Of these, 52 species (28.9%) were trees, 6 species (3.33%) were Trees/shrubs, 31 species (17.22%) were shrubs, 76 species (42.22%) were herbs, and 15 species (8.33%) were Lianas. Rubiaceae, Acanthaceae and Asteraceae were the richest family each represented by 11 genera and 11 species (6.11%), 9 genera and 11 species (6.11%), 6 genera and 11 species (6.11%), respectively of total floristic composition. Cluster analysis resulted in five different plant communities and this result was supported by the ordination result. RDA result showed altitude was the main environmental variable in determining the plant communities. The ANOVA test indicated that the five community types differ significantly from each other with regard to Electrical Conductivity and Potassium. Conclusions: Description of floristic diversity of species in Gerba Dima forest revealed the presence of high species diversity and richness. The presence of endemic plant species in the study forest shows the potential of the area for biodiversity conservation.
Clathrin regulates the β-arrestin pathway regardless of ligand bias
Authors: Shiraki Atsuko , Shimizu Satoshi
Published: November 2021

μ-opioid receptors (MOP) are thought to activate the G protein-mediated analgesic pathway and β-arrestin 2-mediated side effect pathway; however, ligands that recruit β-arrestin 2 only minimally to MOP may also cause opioid side effects. Such side effects are also induced in mutant mice lacking β-arrestin 2 or expressing phosphorylation-deficient MOP that do not recruit β-arrestin 2. These findings critically questioned whether β-arrestin 2 recruitment to MOP triggers side effects. Here, we show that β-arrestin 1 partially compensates for the lack of β-arrestin 2 in a neuronal cell line and thus might be involved in triggering such side effects in β-arrestin 2-null mice. Moreover, the magnitude of β-arrestin-mediated signals is not correlated with β-arrestin recruitment to MOP via phosphorylation of the carboxyl-terminal of MOP, which has long been used to evaluate β-arrestin bias of a ligand. Instead, β-arrestin activates downstream signals by binding with the clathrin heavy chain in the process of clathrin-coated pit formation. Our findings provide not only a novel insight into G protein-coupled receptor-mediated signalling to overcome opioid side effects but also an unexpected concept that the accumulation of molecules required for endocytosis is a key for activating the intracellular signalling.
Structural basis of template strand deoxyuridine promoter recognition by a viral RNA polymerase
Authors: Leiman Petr , Fraser Alec , Sokolova Maria , Drobysheva Arina , Gordeeva Julia , Borukhov Sergei , Team AlphaFold , Severinov Konstantin
Published: November 2021

Recognition of promoters in bacterial RNA polymerases (RNAPs) is controlled by their sigma subunits that first bind to a double-stranded DNA element ~35 to ~14 nucleotides upstream of the transcription start site (TSS) and then capture several bases of the non-template strand ~10 nucleotides upstream of the TSS. Here, we shift this paradigm and explain the mechanism by which the phage AR9 non-virion RNAP (nvRNAP), a bacterial RNAP homolog, recognizes a −10 promoter element in the template strand directly. Together, the AR9 nvRNAP sigma-like subunit, the enzyme core, and the template strand itself form two nucleotide base-accepting pockets whose shapes dictate the AR9 nvRNAP’s deoxyuridine promoter requirement. A single amino acid substitution in the promoter specificity subunit allows one of these pockets to accept a thymine base thus expanding the enzyme’s promoter consensus. Our work demonstrates the extent to which viruses can evolve host-derived multisubunit enzymes to control host takeover.
Nanometre-thick Si/Al Gradient Materials for Sustainable Spin Current Generation
Authors: Horaguchi Taisuke , He Cong , Wen Zhenchao , Ohkubo Tadakatsu , Hono Kazuhiro , Mitani Seiji , Sukegawa Hiroaki , Fujimoto Junji , Yamanoi Kazuto , Matsuo Mamoru , Nozaki Yukio
Published: November 2021

Green materials for electron spin manipulation are essential for common spintronic applications. Recent studies have documented the efficient generation of spin torque using spin-orbit interactions (SOIs); however, SOI use relies on the employment of rare metals such as platinum. Here, we demonstrate that a nanometre-thick gradient from silicon to aluminium, which consists of readily available elements from earth resources, can produce a spin torque over three times as large as that of platinum, despite the weak SOI of these compositions. The spin-torque efficiency can be improved by decreasing the thickness of the gradient, while a sharp interface was not found to increase the spin torque. Moreover, the electric conductivity of the gradient material can be up to twice as large as that of platinum, which provides a way to reduce Joule heating losses and signal delays in spintronic device circuits. Our findings represent a pathway for sustainable spin manipulation.
The pattern of alternative splicing in lung adenocarcinoma shows novel events correlated with tumorigenesis and immune microenvironment
Authors: Wang Gongjun , Qiu Wensheng
Published: November 2021

Lung adenocarcinoma (LUAD) is the leading cause of cancer deaths worldwide due to the lack of early diagnostic markers and specific drugs. Previous studies have shown the association of LUAD growth with aberrant alternative splicing (AS). Herein, clinical data of 535 tumor tissues and 59 normal tissues were extracted from the TCGA database. Each sample was analyzed using the ESTIMATE algorithm; a comparison between higher and lower score groups (stromal or immune) was made to determine the overall- and progression-free survival-related differentially expressed AS (DEAS) events. We then performed unsupervised clustering of these DEASs, followed by determining their relationship with survival rate, immune cells, and the tumor microenvironment (TME). Next, two prognostic signatures were developed using bioinformatics tools to explore the prognosis of cases with LUAD. Five OS- and six PFS-associated DEAS events were implemented to establish a prognostic risk score model. When compared to the high-risk group (HRG), the PFS and OS of the low-risk group (LRG) were found to be considerable. Additionally, a better prognosis was found considerably associated with the ESTIMATE score of the patients as well as immune cells infiltration. Our analysis of AS events in LUAD not only helps to clarify the tumorigenesis mechanism of AS, but also provides ideas for revealing potential prognostic biomarkers and therapeutic targets.
Highly efficient biosorbent produced from Syagrus romanzoffiana to be applied in water treatment
Authors: Tochetto Gabriel André , Silva Tainá Cristini da , Bampi Josiane , Moreira Regina de Fátima Peralta Muniz , Luz Cleuzir da , Pasquali Gean Delise Leal , Dervanoski Adriana
Published: November 2021

A new adsorbent from Jerivá coconut (a native fruit of the Atlantic Forest) was developed through thermal activation at high temperatures and chemical activation using H3PO4. The characterization of activated carbon revealed the functional groups O-H, NH2 and C=C. The morphology showed an irregular and heterogeneous surface, with a pore volume of 0.442 cm3 g−1 and a surface area of 750 m2 g−1. The main variables of the process were evaluated for statistical significance in the removal of the methylene blue dye showing that only the agitation of the system affected the process. Adsorption kinetics were performed at three different concentrations and fitted to nonlinear models where the Avrami-fractional-order model represented the experimental data. Equilibrium occurred within 80 min and was sufficient to remove more than 99% of the initial concentration. The sorption isotherms were performed at four different temperatures, fitted to four nonlinear models. The Sips model obtained the best adjustment, with a maximum adsorption capacity of 254.40 mg g−1, for the highest temperature investigated. The process occurred spontaneously, favorably and endothermically. The results were promising, pointing out that this adsorbent has the potential to remove methylene blue and the treated effluent can be reused for less noble purposes in the industry.
Study on new rocker curves generated by a three diades mechanism
Authors: L Luca
Published: November 2021

Mechanisms generating rocker curves have a great use in the machine building industry. In the specialty literature a lot of papers have been published regarding the analysis and synthesis of mechanisms for rocker curves. In this paper the R-RRR-RPP-RPP mechanism is studied, a three-diade mechanism that generates special rocker curves. There are obtained many rocker curves, most of which are unknown in the mechanisms. A generator point belongs to RPP diade that slides on a rocker and another is on another RPP diade sliding on a rotating moving element. The rocker curves generated by the point that slides on a rocker are more complicated and more interesting than those at which the generator point slides on a rotating motion element. The angles between the welded slides have changed and the same curve shapes have been obtained, with some modifications and different positions on the axis system. In this way a wide range of special rocker curves generated by the mechanisms were obtained. The results obtained from the study can be used in the design of new mechanisms generating of rocker curves.
Contributions to the study of the behavior of gas turbine propulsion systems at changes in environmental for all operating parameters
Authors: Ion-Adrian Gîrbă
Published: November 2021

The paper encompasses the study of the evolution of the functional parameters (suction air mass flow rate, plant efficiency, etc.) of naval gas turbines propulsion systems at changes in environmental parameters. The operational parameters of a gas turbine propulsion system and their evolution in relation to the modification of the environmental status parameters have been highlighted by calculation. Another sensitive area in the operation of gas turbine installations is the transient operating modes (stopping, starting, accelerating and decelerating sequences of the installation), which were highlighted by determinating of operating parameters on board the ship.
Considerations regarding the use of the Marine Gearbox in Gas Turbine Propulsion for Particular Ships
Authors: T M Ștefănescu
Published: November 2021

The use of the marine gearbox is very important in most propulsion systems based on gas turbines, due to the high value of the turbine speed – propeller shaft ratio. Particular ships’ characteristics differ from the civilian ships with several features which gives them the ability to navigate for a long time under different conditions. As a result of this navigating conditions, the main gearing inside the gearbox will find itself under different stages of structural stress. The stages will be analyzed by using the finite element analysis. The stress degree can be minimized by carefully choosing the correct type of material for the gearing, which is in close connection with the amount of heat that is dissipated due to meshing under different conditions. The purpose of this paper is the optimization of the gearing inside the gearbox such it can suffer as small as possible structural deformations under the factors determined by the use of the gearbox under different working conditions.
Influence of Elastic Element Design Parameters on Buckling Effect for Different „Periflex“ Shaft Couplings
Authors: E Ivanova
Published: November 2021

In the article has made research into the buckling resistance of flexible shaft coupling with toroidal elastic element. It is made a comparison between four different designs of “Periflex” coupling, the received data are preparing and systemizing. The obtained data show how the con-struction parameters of the elastic element influence to the critical buckling torque. The data ob-tained can be used to design a shaft coupler that will transmission a higher torque with used of smaller quantity of material.
TECS - a Dedicated Software for Thermal Engine Calculation
Authors: Andrei Cebanu
Published: November 2021

This paper addresses the thermal engine calculation problematics using a dedicated software program (TECS) in order to determine the indicated and effective engine parameters using different fuels (liquid or gaseous). The diagram indicated thus obtained by TECS can contribute to verify the judicious use of thermal energy, obtained through combustion of fuel and its transformation into Mechanical Work. The analysed thermo-dynamic processes can analytically and graphically determine the polytrophic exponents of compression and decomposition in values close to the stoichiometric calculations. The TECS software is addressed to the current and future electro-mechanical naval engineers with concrete concerns in verification, analysis and calculation of thermo-dynamic processes that govern the operation of the ship internal combustion engine. It can be a starting point eloquently in appreciation of fair uses thermal energy on board.
Influence of friction in the drawing a cylindrical part steel – part II
Authors: A. Chioibas
Published: November 2021

In this paper we analyze the variations of the deformations, of the flow stresses, of the thickness of the walls, in the case of the simulation of the drawing process carried out under two conditions: without using the lubricant and using one in liquid form. The analysis presented aims to determine the influence of friction on the quality of the drawing B steel piece.
Establishment of criterion equation of water flow phenomenon around the ship
Authors: B Ali
Published: November 2021

Applying similarity theorem on the study of water flow around ship’s hull, similarity criterias are obtained, by which it can be determined physical size values of the prototype vessel, based on measurements performed on the model ship.
Celastrol Inhibits the Proliferation and Induces Apoptosis of Colorectal Cancer Cells
via Downregulating NF-κB/COX-2 Signaling Pathways
Authors: Zhu Jiabin , Zhang Hua , Zhao Xiaojin , Shang Fajun , Sun Huan , Zheng Xu
Published: November 2021

Background:

Colorectal cancer (CRC) is the third-ranked malignant tumor in the world that contributes to
the death of a major population of the world. Celastrol, a bioactive natural product isolated from the medicinal plant
Tripterygium wilfordii Hook F, has been proved to be an effective anti-tumor inhibitor for multiple tumors.

Objective:

To reveal the therapeutic effect and underlying mechanisms of celastrol on CRC cells.

Methods:

CCK-8 and clonogenic assay were used to analyze the cell proliferation in CRC cells. Flow cytometry analysis
was conducted to assess the cell cycle and cell apoptosis. Wound-healing and cell invasion assay were used to
evaluate the migrating and invasion capability of CRC cells. The potential antitumor mechanism of celastrol was investigated
by qPCR, western blot, and confocal immunofluorescence analyses.

Results:

Celastrol effectively inhibited CRC cell proliferation by activating caspase-dependent cell apoptosis and facilitating
G1 cell cycle arrest in a dose-dependent manner, as well as cell migration and invasion by downregulating the
MMP2 and MMP9. Mechanistic protein expression revealed that celastrol suppressed the expression of COX-2 by
inhibiting the phosphorylation of NF-κB p65 and subsequently leading to cytoplasmic retention of p65 protein, thereby
inhibiting its nuclear translocation and transcription activities.

Conclusion:

These findings indicate that celastrol is an effective inhibitor for CRC, regulating the NF-κB/COX-2
pathway, leading to the inhibition of cell proliferation characterized by cell cycle arrest and caspase-dependent apoptosis,
providing a potential alternative therapeutic agent for CRC patients.
Effectiveness of one-stop integrated services in optimizing the role of Indonesian migrant workers protection agency in Central Java
Authors: Shalihah Fithriatus , Agusmidah Agusmidah , Wijayanti Asri
Published: November 2021

This study aims to determine the application of an integrated service system in several Central Java districts to protect Indonesian workers. This research uses the observational method. This study involved seven districts contributing to Indonesian workers in the province of Central Java. The sample districts include Banyumas, Cilacap, Pati, Kendal, Sragen, Grobogan and Wonosobo. The data were obtained utilizing field observations, interviews, quinones and literature studies, analyzed using the Miles and Huberman models, namely data reduction, data tabulation, data presentation and conclusion drawing. The study results show that the One-Stop Integrated Service also helps reduce Illegal Indonesian Migrant Workers and prevents document falsification. Limited Human Resources (HR) who can act as operator staff at LTSA office outlets are also a factor in the ineffectiveness of the One-Stop Integrated Service. This means that the presence of LTSA in various districts/cities in Central Java can facilitate the role of BP2MI in carrying out its functions. However, it cannot run effectively as a whole.
Evaluación de la calidad de vida en el trabajo en productores de café en Cundinamarca, Colombia
Authors: Rodríguez Rojas Yuber Liliana , Rodríguez Vásquez William Camilo , Peñarete Moreno Daniel Felipe
Published: November 2021

En Colombia, más de la mitad de la población que pertenece al sector agrícola  vive en condiciones de pobreza o pobreza extrema, no obstante, se requiere indagar otras dimensiones como la calidad de vida, que se relaciona con el bienestar, las condiciones de vida y la satisfacción de la población. El objetivo de esta investigación fue evaluar la calidad de vida en el trabajo de productores de café en el departamento de Cundinamarca, teniendo en cuenta que Colombia es el tercer productor de café en el mundo. Para evaluar la calidad de vida en el trabajo de los caficultores se realizó una adaptación del instrumento GOHISALO, redefinido en 7 dimensiones y 56 ítems de los 74 que originalmente estructuran el instrumento. El instrumento propuesto obtuvo una alta confiabilidad con un alfa de Cronbach de 0,96 y un KMO de 0,81. Se realizaron 109 encuestas en los municipios de Cáqueza, Guayabetal y Quetame en Cundinamarca en el 2019. En términos generales la percepción de calidad de vida de los caficultores de Cáqueza, Guayabetal y Quetame es buena en la mayoría de las dimensiones analizadas, excepto en la dimensión de seguridad para el trabajo. También se encontró una diferencia en la variable de género respecto a la percepción de calidad de vida en las mujeres, la cual se ubica en todas las dimensiones por debajo del resultado de los hombres.
Callogénesis in vitro de durazno (Prunus persica L.) var. Huayco rojo a partir de explantes foliares
Authors: Hernández-Amasifuen Angel David , Cortez-Lázaro Anthony Apolinario , Argüelles-Curaca Alexis , Díaz-Pillasca Hermila Belba
Published: November 2021

El durazno (Prunus persica L.) presenta en la actualidad gran importancia económica para el Perú, el incrementar su exportación cada año, siendo la variedad Huayco rojo el de mayor producción y exportación por presentar un agradable sabor y gran aceptación en el mercado exterior. En la búsqueda de expandir las áreas de este cultivo se han realizado estudios de multiplicación empleando métodos biotecnológicos como la micropropagación in vitro, pero se han presentado problemas con esta especie por ser de comportamiento recalcitrante. Por lo que dentro de las alternativas para obtener mayor número de clones de gran calidad y productividad el presente trabajo de investigación tuvo como objetivo desarrollar una metodología eficiente de inducción de callos in vitro en durazno variedad Huayco rojo a partir de hojas. Determinando primero la concentración de hipoclorito de sodio que permita obtener mayor desinfección y menor daño a los explantes de hojas de durazno, Posteriormente los explantes fueron introducidos en medios de cultivo MS adicionado con tratamientos de 2,4-D y agua de coco en diferentes concentraciones. Induciendo callos in vitro en durazno variedad Huayco rojo a partir de hojas, obteniendo 100% de inducción de callos empleando a partir de 1 mg/L de 2,4-D más 50 mL/L de agua de coco. Finalmente, los resultados de esta investigación permiten recomendar el uso de 2,4-D y agua de coco en la inducción del proceso de callogénsis en Prunus persica L. variedad Huayco rojo.
Opportunities and Challenges for Professionals in Psychiatry and Mental Health Care Using Digital Technologies During the COVID-19 Pandemic: Systematic Review
Authors: Kane Hélène , Gourret Baumgart Jade , El-Hage Wissam , Deloyer Jocelyn , Maes Christine , Lebas Marie-Clotilde , Marazziti Donatella , Thome Johannes , Fond-Harmant Laurence , Denis Frédéric
Published: November 2021

Background

The COVID-19 pandemic has required psychiatric and mental health professionals to change their practices to reduce the risk of transmission of SARS-CoV-2, in particular by favoring remote monitoring and assessment via digital technologies.

Objective

As part of a research project that was cofunded by the French National Research Agency (ARN) and the Centre-Val de Loire Region, the aim of this systematic literature review was to investigate how such uses of digital technologies have been developing.

Methods

This systematic review was conducted following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The search was carried out in the MEDLINE (ie, PubMed) and Cairn databases, as well as in a platform specializing in mental health, Ascodocpsy. The search yielded 558 results for the year 2020. After applying inclusion and exclusion criteria, first on titles and abstracts and then on full texts, 61 articles were included.

Results

The analysis of the literature revealed a heterogeneous integration of digital technologies, not only depending on countries, contexts, and local regulations, but also depending on the modalities of care. Notwithstanding these variations, the use of videoconferencing has developed significantly, affecting working conditions and therapeutic relationships. For many psychiatric and mental health professionals, the pandemic has been an opportunity to build up their experience of remote care and, thus, better identify the possibilities and limits of these digital technologies.

Conclusions

New uses of such technologies essentially consist of a transition from the classic consultation model toward teleconsultation and make less use of the specific potential of artificial intelligence. As professionals were not prepared for these uses, they were confronted with practical difficulties and ethical questions, such as the place of digital technology in care, confidentiality and protection of personal data, and equity in access to care. The COVID-19 health crisis questions how the organization of health care integrates the possibilities offered by digital technology, in particular to promote the autonomy and empowerment of mental health service users.
Event Prediction Model Considering Time and Input Error Using Electronic Medical Records in the Intensive Care Unit: Retrospective Study (Preprint)
Authors: Sung MinDong , Hahn Sangchul , Han Chang Hoon , Lee Jung Mo , Lee Jayoung , Yoo Jinkyu , Heo Jay , Kim Young Sam , Chung Kyung Soo
Published: November 2021

BACKGROUND

In the era of artificial intelligence, event prediction models are abundant. However, considering the limitation of the electronic medical record–based model, including the temporally skewed prediction and the record itself, these models could be delayed or could yield errors.

OBJECTIVE

In this study, we aim to develop multiple event prediction models in intensive care units to overcome their temporal skewness and evaluate their robustness against delayed and erroneous input.

METHODS

A total of 21,738 patients were included in the development cohort. Three events—death, sepsis, and acute kidney injury—were predicted. To overcome the temporal skewness, we developed three models for each event, which predicted the events in advance of three prespecified timepoints. Additionally, to evaluate the robustness against input error and delays, we added simulated errors and delayed input and calculated changes in the area under the receiver operating characteristic curve (AUROC) values.

RESULTS

Most of the AUROC and area under the precision-recall curve values of each model were higher than those of the conventional scores, as well as other machine learning models previously used. In the error input experiment, except for our proposed model, an increase in the noise added to the model lowered the resulting AUROC value. However, the delayed input did not show the performance decreased in this experiment.

CONCLUSIONS

For a prediction model that was applicable in the real world, we considered not only performance but also temporal skewness, delayed input, and input error.
App Designs and Interactive Features to Increase mHealth Adoption: User Expectation Survey and Experiment (Preprint)
Authors: Lazard Allison J , Babwah Brennen J Scott , Belina Stephanie P
Published: November 2021

BACKGROUND

Despite the ubiquity of smartphones, there is little guidance for how to design mobile health apps to increase use. Specifically, knowing what features users expect, grab their attention, encourage use (via predicted use or through positive app evaluations), and signal beneficial action possibilities can guide and focus app development efforts.

OBJECTIVE

We investigated what features users expect and how the design (prototypicality) impacts app adoption.

METHODS

In a web-based survey, we elicited expectations, including presence and placement, for 12 app features. Thereafter, participants (n=462) viewed 2 health apps (high prototypicality similar to top downloaded apps vs low prototypicality similar to research interventions) and reported willingness to download, attention, and predicted use of app features. Participants rated both apps (high and low) for aesthetics, ease of use, usefulness, perceived affordances, and intentions to use.

RESULTS

Most participants (425/462, 92%) expected features for navigation or personal settings (eg, menu) in specific regions (eg, top corners). Features with summary graphs or statics were also expected by many (395-396 of 462, 86%), with a center placement expectation. A feature to “share with friends” was least expected among participants (203/462, 44%). Features fell into 4 unique categories based on attention and predicted use, including essential features with high (>50% or >231 of 462) predicted use and attention (eg, calorie trackers), flashy features with high attention but lower predicted use (eg, links to specific diets), functional features with modest attention and low use (eg, settings), and mundane features with low attention and use (eg, discover tabs). When given a choice, 347 of 462 (75%) participants would download the high-prototypicality app. High prototypicality apps (vs low) led to greater aesthetics, ease of use, usefulness, and intentions, (for all, P<.001). Participants thought that high prototypicality apps had more perceived affordances.

CONCLUSIONS

Intervention designs that fail to meet a threshold of mHealth expectations will be dismissed as less usable or beneficial. Individuals who download health apps have shared expectations for features that should be there, as well as where these features should appear. Meeting these expectations can improve app evaluations and encourage use. Our typology should guide presence and placement of expected app features to signal value and increase use to impact preventive health behaviors. Features that will likely be used and are attention-worthy—essential, flashy, and functional—should be prioritized during app development.
Data-adaptive Fellegi-Sunter Model for Probabilistic Record Linkage: Incorporating Missing Data and Field Selection (Preprint)
Authors: Li Xiaochun , Xu Huiping , Grannis Shaun
Published: November 2021

UNSTRUCTURED

Objectives: We address the real-world challenges of missing data and matching field selection in linking medical records by evaluating the extent to which incorporating the missing-at-random assumption in the Fellegi-Sunter model and using data-driven selected fields improve patient matching accuracy using real-world use cases.
Methods: We adapted the Fellegi-Sunter model to accommodate missing data using the missing-at-random assumption and compared the adaptation to the common strategy of treating missing values as disagreement, with matching fields specified by experts or selected by data-driven methods. We used four use cases, each containing a random sample of record pairs with match status ascertained by manual reviews. Use cases included health information exchange (HIE) record deduplication, linkage of public health registry records to HIE, linkage of Social Security Death Master File records to HIE, and deduplicating newborn screening records, which represent real-world clinical and public health scenarios. Matching performance was evaluated using sensitivity, specificity, positive predictive value, negative predictive value, and F-score.
Results: Incorporating the missing-at-random assumption in the Fellegi-Sunter model maintained or improved F-scores whether matching fields were expert-specified or selected by data-driven methods. Combining the missing-at-random assumption and data-driven fields optimized F-scores in the four use cases.
Conclusions: Missing-at-random is a reasonable assumption in real-world record linkage applications: it maintains or improves F-scores regardless of whether matching fields are expert-specified or data-driven. Data-driven selection of fields coupled with MAR achieves the best overall performance, which can be especially useful in privacy-preserving record linkage.
Authors' Responses to Peer Review of “Influence of the COVID-19 Lockdown on the Physical and Psychosocial Well-being and Work Productivity of Remote Workers: Cross-sectional Correlational Study” (Preprint)
Authors: Tronco Hernández Yessica Abigail , Parente Fabio , Faghy Mark A , Roscoe Clare M P , Maratos Frances A
Published: November 2021

UNSTRUCTURED

These are authors' responses to peer review.
User Engagement in Gamified Online Learning System
Authors: Shrestha Sushil , Joshi Manish , Bashyal Akash , Timilsina Arun
Published: November 2021

The study in this research has demonstrated the effectiveness of gamification in changing user behavior and improving user engagement from a psychological perspective. To achieve that, gamification features are integrated in an Online Learning (OL) system. The study is based on self-determination theory, which states that people are motivated to grow and change when three innate psychological needs: competence, autonomy, and relevance are satisfied. Gamification features that can positively support psychological needs are identified through various literature studies and implemented in OL systems. Hence this research is based on a design-based approach in which a tool is developed to observe different behaviors and activities of the students and measure the user engagement directly from the user interactions in an OL system. The results suggest that two psychological needs: competence and relatedness are the main determinants of engagement. The findings suggest that students showed significant user engagement in a gamified OL system. Instructors, students, and researchers (working in the area for improving OL systems) are highly benefited by this research.
Study of the effect of chalcopyrite and pyrite minerals on the oxidation of copper sulfide concentrate
Authors: G Gereltuya. , B Maralmaa. , D Erdenechimeg.
Published: November 2021

Changes in the weight of copper concentrate from oxidation and a decrease in copper content create economic losses. Mining plants having problems with increasing overall weight of the copper concentrate and reduction of the copper composition after a certain period of transport and handling. Trivalent iron, one of the main oxidizing factors of the copper concentrate, is a strong oxidizer that oxidized copper sulfide minerals as well as other minerals in the concentrate, which is formed by the oxidation of pyrite. Generally, mass change can occur during electron transition and phase transfer. Therefore, the chemical mechanism, oxidation process, and content alteration of the main components in copper concentrate were studied in this study in order to solve and define those problems. To study the real condition of the copper concentrate oxidation, the oxidation process of the copper concentrate was studied under 3 conditions such as in the shadow, in the sun, and the storage. Mongolian National Standard and International standards (MNS2078:1984, ISO 10258:2018) and XRD, AAS, ICP analysis were used to study the main components of the copper concentrate. By the study on the oxidation of copper concentrate at the mine site, copper was decreased by 0.77-0.85%, and iron was reduced by 0.30-0.64%. As a result of the oxidation study of concentrate that is kept in the mining site, temperature, relative humidity, and pH were highly correlated with concentrate oxidation.
ЮМСЫН ИНТЕРНЭТИЙН ХӨДӨЛГӨГЧИД ЧИГЛЭСЭН ХАЛДЛАГЫГ МАШИН СУРГАЛТЫН АЛГОРИТМ АШИГЛАН ИЛРҮҮЛЭХ НЬ
Authors: Угтахбаяр Н. , Болд П. , Өсөхбаяр Б.
Published: November 2021

Юмсын интернэтийн төхөөрөмжийн хэрэглээ асар хурдацтай нэмэгдэх хирээр тухайн төхөөрөмжид чиглэсэн халдлагууд мөн адил өсөж байна. Халдлагын тоо өсөхөөс гадна халдлага амжилттай болох магадлал улам бүр нэмэгдэж буй нь өнөөдрийн байдлаар IP сүлжээний орчинд ашиглагдаж буй аюулгүй байдлын шийдэл, технологиудыг юмсын интернэтийн орчинд ашиглах боломж хомс байгаатай холбоотой. Үүнээс гадна олон хувь борлуулагдаж буй төхөөрөмжүүдэд чиглэсэн халдлага тасралтгүй гарсаар байх нь зайлшгүй болж байна. Энэхүү судалгааны ажлын хүрээнд андройд утас, лед гэрэл, температурын сенсор, Apple-ийн ухаалаг цаг зэргийн өгөгдөлд тулгуурлан халдлага илрүүлэх туршилтыг хийж гүйцэтгэсэн бөгөөд юмсын интернэтийн төхөөрөмжийн төрлөөс хамаарч аюулгүй байдлын ялгаатай шийдлүүд хэрэглэх хэрэгтэй гэж үзсэн.
Submission has not been previously published
Authors: Gan Amaraa
Published: November 2021

Submission has not been previously published Submission has not been previously published Submission has not been previously published Submission has not been previously published Submission has not been previously published Submission has not been previously published Submission has not been previously published Submission has not been previously published Submission has not been previously published Submission has not been previously published Submission has not been previously published Submission has not been previously published Submission has not been previously published Submission has not been previously published Submission has not been previously published Submission has not been previously published Submission has not been previously published
5G СҮЛЖЭЭН ДЭХ ТАРХСАН ХӨДӨЛГӨӨНТ БАЙДЛЫН УДИРДЛАГАД ЗОРИУЛСАН ХЭРЭГЛЭГЧИЙН БАТАЛГААЖУУЛАХ МЕХАНИЗМТАЙ ХЭНДОВР
Authors: Шүхэрт Д. , Баттулга Д. , Өсөхбаяр Б.
Published: November 2021

Мобайл сүлжээний үндсэн үүрэг нь яриа дамжуулахаас өгөгдөл дамжуулах болон өөрчлөгдөж байна. 5G сүлжээ нь хөдөлгөөнт хэрэглэгчийг өндөр хурдны интернетээр хангах үндсэн зорилготой юм. Тэгвэл мобайл сүлжээнд хэрэглэгчийн хөдөлгөөнийг хянах үүрэгтэй нэгж нь интернет үйлчилгээний тасралтгүй, найдвартай байдлыг хангах чухал үүрэгтэй юм. 5G сүлжээний стандартад тархсан хөдөлгөөнт байдлын удирдлага багтсан боловч хэрэглэгчийн баталгаажуулах механизмгүйгээрээ сул талтай байна. Энэхүү судалгааны ажлаар бид хөдөлгөөнт байдлын удирдлагад хэрэглэгчийг баталгаажуулахад хэш функц ашиглах сайжруулалт хийснээ танилцуулсан. Энэхүү хэрэглэгчийг баталгаажуулах үйлдэл нь сүлжээн дэх системийн түвшний халдлагуудаас хамгаалах үндсэн зорилготой юм. Мөн энэхүү ажлаараа туршилтын орчин зохион байгуулж санал болгож байгаа сайжруулалт болон боломжит баталгаажуулалтын шийдлүүдтэй харьцуулалт хийж үр дүнг тайлагнав. Үр дүнгээс, бидний сайжруулалт хэндоврын хоцролтыг ихэсгэх боловч пакетын алдагдал багасгаж, хөнөөлт анкөртай үед алдаа бага гаргаж байгаа сайн талтай байна.
Development of Modified Fractional Fluid Flow Equation For Non – Darcy Flow in Computer Simulation of Oil Reservoirs.
Authors:   *1,3Department of Petroleum Engineering, University of Ibadan, Ibadan. Oyo State. Nigeria. 2Department of Mechanical Engineering, First Technical University, Ibadan. Oyo State. Nigeria, Akintola S. A. , Adeaga O. A. , Muritala O. K.
Published: November 2021

Development of Modified Fractional Fluid Flow Equation For Non – Darcy Flow in Computer Simulation of Oil Reservoirs *1Akintola, S. A., 2Adeaga, O. A. & 3Muritala, O. K. *1,3Department of Petroleum Engineering, University of Ibadan, Ibadan. Oyo State. Nigeria. 2Department of Mechanical Engineering, First Technical University, Ibadan. Oyo State. Nigeria Corresponding Author: sarah.akintola@ui.edu.ng (+2348023363651) ABSTRACT Upon the depletion of oil reservoir, huge amount of oil is usually left behind. This oil, in some cases double the initial oil recovered, in order to recover the unrecovered oil, different types of secondary oil recovery techniques can be explored. A more common techniques is water flooding which involve the injection of water into reservoir to displace oil into the wellbore. To determine the relative flow rates of oil and water at any point in a porous flow system while also examining factors such as fluid properties, rock properties, reservoir structural properties, pressure gradient, and flow rate which affect the displacement efficiency of a water flooding project, the fractional flow equation is employed. But the convectional fractional flow equation is applicable just to Darcy flow. The use of Darcy flow equation is not applicable in low permeability sandstone reservoir, hence non Darcy flow have been used one of such equation is the Forcheimer equation, as a result this study is aimed at modifying the Forcheimer equation and validating the new fractional flow equation using literature. The result obtained showed that the proposed equation predicts better than Forcheimer equation Keyword: Darcy flow, Forcheimer equation, water flooding fractional flow equation, Proceedings Reference Format (2021):
A rare case of spontaneous perirenal hemorrhage - Wunderlich syndrome
Authors: Arandjelovic Goran , Lai Stefano , Milani Claudio
Published: November 2021

Introduction. Spontaneous perirenal hemorrhage or Wunderlich syndrome represents a rare entity in urological settings. The vast majority of the causes are represented by angiomyolipoma and renal cell carcinoma. In other cases, vascular abnormalities, polycystic kidneys, polyarthritis nodosa, or pyelonephritis could represent the cause of perirenal bleeding. The treatment depends on the clinical parameters at the presentation as well as on the possible presence of renal malignancies. Our goal was to present a rare case of a healthy men who presented the idiopathic Wunderlich syndrome. Case outline. We present a case of a 50-year-old patient with spontaneous perirenal hemorrhage that was not due to any defined cause even after a six-months follow-up. Conclusion. In some rare cases of perirenal bleeding, the cause cannot be defined at the presentation, even with today?s advanced radiological imaging methods. Thus, it is important to be aware of the fact that in those cases, a longer follow-up is needed, knowing that the presence of perirenal hematoma can always obscure the real diagnosis. Sometimes, even in cases where the proper follow-up has been done, the real cause of the bleeding remains unknown.