bluuebunny/crossref_metadata_2025 huggingface dataset:
Plasmodium manipulates the expression of host long non-coding RNA during red blood cell intracellular infection
Authors: Chen Guang , Liu Shuang-chun , Fan Xiao-yan , Jin Yue-lei , Li Xin , Du Yun-ting
Published: May 2022

Background

Parasites interact with their host through “direct” and/or “indirect” mechanisms. Plasmodium, for example, either mediates direct physical interactions with host factors or triggers the immune system of the host indirectly, leading to changes in infectious outcomes. Long non-coding RNAs (lncRNAs) participate in regulating biological processes, especially host–pathogen interactions. However, research on the role of host lncRNAs during Plasmodium infection is limited.

Methods

A RNA sequencing method (RNA-seq) was used to confirm the differential expression profiles of lncRNAs in Plasmodium yeolii 17XL (P.y17XL)-infected BALB/c mice. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed to elucidate the potential functions of Plasmodium-induced genes. Subsequently, the effect of specific lncRNAs on the modulation of immune-related signaling pathways in malaria was determined by fluorescence-activated cell sorting, western blot and enzyme-linked immunosorbent assay.

Results

The data showed that in P.y17XL-infected BALB/c mice, Plasmodium upregulated the expression of 132 lncRNAs and downregulated the expression of 159 lncRNAs. Differentially expressed lncRNAs clearly associated with malaria infection were annotated, including four novel dominant lncRNAs: ENMSUSG00000111521.1, XLOC_038009, XLOC_058629 and XLOC_065676. GO and KEGG pathway analyses demonstrated that these four differentially expressed lncRNAs were associated with co-localized/co-expressed protein-coding genes that were totally enriched in malaria and with the transforming growth factor beta (TGF-β) signaling pathway. Using the models of P.y17XL-infected BALB/c mice, data certified that the level of TGF-β production and activation of TGF-β/Smad2/3 signaling pathway were obviously changed in malaria infection.

Conclusions

These differentially expressed immune-related genes were deemed to have a role in the process of Plasmodium infection in the host via dendritic/T regulatory cells and the TGF-β/Smad2/3 signaling pathway. The results of the present study confirmed that Plasmodium infection-induced lncRNA expression is a novel mechanism used by Plasmodium parasites to modify host immune signaling. These results further enhance current understanding of the interaction between Plasmodium and host cells.

Graphical Abstract
Infective endocarditis with Osler’s nodule in a patient with Osler’s disease: a case report and review of the literature
Authors: Naruse Genki , Watanabe Takatomo , Okura Hiroyuki
Published: May 2022

Background

Hereditary hemorrhagic telangiectasia, also known as Osler–Weber–Rendu disease, induces arteriovenous malformations in visceral organs. Arteriovenous malformations increase the risk of severe infections and are a common complication associated with hemorrhagic telangiectasia. However, cases of endocarditis associated with hemorrhagic telangiectasia are rarely reported. Although hemorrhagic telangiectasia causes erythematous macules on the extremities, these macules are usually painless. We encountered a rare case of infective endocarditis in a patient with Osler–Weber–Rendu disease.

Case presentation

A 52-year-old Japanese woman who was diagnosed with hemorrhagic telangiectasia 5 years prior presented to our hospital with fever and muscular pain. She had erythematous nodules and tenderness on the finger, heel, and toe, suggestive of Osler’s nodes. A physical examination revealed tachycardia with a 3/6 pansystolic murmur. A transesophageal echocardiogram showed vegetations along the atrial side of the mitral valve and mild mitral regurgitation because of prolapse of the anterior commissure. Methicillin-sensitive Staphylococcus aureus was identified in the blood cultures. Detection of distinctive skin lesions, so-called Osler’s nodes, was the symptomatic key to early diagnosis, and the patient was treated without surgery. She was discharged with negative blood cultures after a 6-week intravenous antibiotic administration.

Conclusions

Our report highlights the importance of considering the risk of extracerebral infections including endocarditis in hemorrhagic telangiectasia. This rare case effectively demonstrates the importance of proper diagnosis of skin lesions.
Bariatric Surgery-induced High-density Lipoprotein Functionality Enhancement Is Associated With Reduced Inflammation
Authors: Adam Safwaan , Ho Jan H , Liu Yifen , Siahmansur Tarza , Siddals Kirk , Iqbal Zohaib , Azmi Shazli , Senapati Siba , New John , Jeziorska Maria , Ammori Basil J , Syed Akheel A , Donn Rachelle , Malik Rayaz A , Durrington Paul N , Soran Handrean
Published: May 2022

Background

Emerging evidence suggests an association between impaired high-density lipoprotein (HDL) functionality and cardiovascular disease (CVD). HDL is essential for reverse cholesterol transport (RCT) and reduces inflammation and oxidative stress principally via paraoxonase-1 (PON1). RCT depends on HDL’s capacity to accept cholesterol (cholesterol efflux capacity [CEC]) and active transport through ATP-binding cassette (ABC) A1, G1, and scavenger receptor-B1 (SR-B1). We have studied the impact of Roux-en-Y gastric bypass (RYGB) in morbidly obese subjects on RCT and HDL functionality.

Methods

Biomarkers associated with increased CVD risk including tumour necrosis factor-α (TNF-α), high-sensitivity C-reactive protein (hsCRP), myeloperoxidase mass (MPO), PON1 activity, and CEC in vitro were measured in 44 patients before and 6 and 12 months after RYGB. Overweight but otherwise healthy (mean body mass index [BMI] 28 kg/m2) subjects acted as controls. Twelve participants also underwent gluteal subcutaneous adipose tissue biopsies before and 6 months after RYGB for targeted gene expression (ABCA1, ABCG1, SR-B1, TNF-α) and histological analysis (adipocyte size, macrophage density, TNF-α immunostaining).

Results

Significant (P < 0.05) improvements in BMI, HDL-cholesterol, hsCRP, TNF-α, MPO mass, PON1 activity, and CEC in vitro were observed after RYGB. ABCG1 (fold-change, 2.24; P = 0.005) and ABCA1 gene expression increased significantly (fold-change, 1.34; P = 0.05). Gluteal fat adipocyte size (P < 0.0001), macrophage density (P = 0.0067), and TNF-α immunostaining (P = 0.0425) were reduced after RYBG and ABCG1 expression correlated inversely with TNF-α immunostaining (r = -0.71; P = 0.03).

Conclusion

RYGB enhances HDL functionality in association with a reduction in adipose tissue and systemic inflammation.
Strengthening Diabetes Care in Humanitarian Crises in Low- and Middle-income Settings
Authors: Kehlenbrink Sylvia , Ansbro Éimhín , Besançon Stéphane , Hassan Saria , Roberts Bayard , Jobanputra Kiran
Published: May 2022

Amid the growing global diabetes epidemic, the scale of forced displacement resulting from armed conflict and humanitarian crises is at record-high levels. More than 80% of the displaced population lives in lower- and middle-income countries, which also host 81% of the global population living with diabetes. Most crises are protracted, often lasting decades, and humanitarian aid organizations are providing long-term primary care to both the local and displaced populations. Humanitarian crises are extremely varied in nature and occur in contexts that are diverse and dynamic. The scope of providing diabetes care varies depending on the phase of the crisis. This paper describes key challenges and possible solutions to improving diabetes care in crisis settings. It focuses on (1) ensuring a reliable supply of life preserving medications and diagnostics, (2) restoring and maintaining access to health care, and (3) adapting service design to the context. These challenges are illustrated through case studies in Ukraine, Mali, the Central African Republic, and Jordan.
Serum Fetuin-A and Risk of Gestational Diabetes Mellitus: An Observational Study and Mendelian Randomization Analysis
Authors: Wu Ping , Wang Yi , Ye Yi , Yang Xue , Lu Qi , Yuan Jiaying , Zha Li , Liu Yan , Song Xingyue , Yan Shijiao , Wen Ying , Qi Xiaorong , Yang Chun-Xia , Wang Yixin , Liu Gang , Lv Chuanzhu , Pan Xiong-Fei , Pan An
Published: May 2022

Context

Fetuin-A was reported to be associated with risk of type 2 diabetes, but its association with incident gestational diabetes mellitus (GDM) was less studied.

Objective

We aimed to examine the association between fetuin-A levels in early pregnancy and risk of incident GDM and to evaluate whether this association was causal.

Methods

A total of 332 pregnant women with GDM and 664 matched controls were included in this nested case-control study. Multivariable conditional logistic regression was applied to investigate the prospective association between serum fetuin-A in early pregnancy and subsequent risk of GDM. Two-sample Mendelian randomization (MR) analysis was used to examine the causal association, using summary statistics from the CHARGE Consortium and the FinnGen consortium.

Results

The mean age of the participants was 28.0 years, and the mean gestational age was 11.0 weeks (range 6-15) at enrollment. In the final model, the odds ratio (OR) for GDM comparing the extreme quartiles of fetuin-A levels was 1.78 (95% CI 1.06, 2.98; P for trend = 0.009), and the restricted cubic spline analysis indicated a linear association (P for nonlinearity = 0.83). This positive association was found in women with waist circumference <80 cm but not in those with waist circumference ≥80 cm (P for interaction = 0.04). However, MR analyses showed no evidence of a causal association with an OR of 0.91 (95% CI 0.67, 1.23) per unit increment of fetuin-A.

Conclusions

Serum fetuin-A levels in early pregnancy were positively associated with risk of GDM, particularly in those with normal waist circumference. However, we found no genetic evidence for a causal association.
Excess Growth Hormone Alters the Male Mouse Gut Microbiome in an Age-dependent Manner
Authors: Jensen Elizabeth A , Young Jonathan A , Jackson Zachary , Busken Joshua , Kuhn Jaycie , Onusko Maria , Carroll Ronan K , List Edward O , Brown J Mark , Kopchick John J , Murphy Erin R , Berryman Darlene E
Published: May 2022

The gut microbiome has an important role in host development, metabolism, growth, and aging. Recent research points toward potential crosstalk between the gut microbiota and the growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis. Our laboratory previously showed that GH excess and deficiency are associated with an altered gut microbial composition in adult mice. Yet, no study to date has examined the influence of GH on the gut microbiome over time. Our study thus tracked the effect of excess GH action on the longitudinal changes in the gut microbial profile (ie, abundance, diversity/maturity, predictive metabolic function, and short-chain fatty acid [SCFA] levels) of bovine GH (bGH) transgenic mice at age 3, 6, and 12 months compared to littermate controls in the context of metabolism, intestinal phenotype, and premature aging. The bGH mice displayed age-dependent changes in microbial abundance, richness, and evenness. Microbial maturity was significantly explained by genotype and age. Moreover, several bacteria (ie, Lactobacillus, Lachnospiraceae, Bifidobacterium, and Faecalibaculum), predictive metabolic pathways (such as SCFA, vitamin B12, folate, menaquinol, peptidoglycan, and heme B biosynthesis), and SCFA levels (acetate, butyrate, lactate, and propionate) were consistently altered across all 3 time points, differentiating the longitudinal bGH microbiome from controls. Of note, the bGH mice also had significantly impaired intestinal fat absorption with increased fecal output. Collectively, these findings suggest that excess GH alters the gut microbiome in an age-dependent manner with distinct longitudinal microbial and predicted metabolic pathway signatures.
Bargaining with Mechanisms
Authors: Pȩski Marcin
Published: May 2022

Two players bargain over a single indivisible good and a transfer, with one-sided incomplete information about preferences. Both players can offer arbitrary mechanisms to determine the allocation. We show that there is a unique perfect Bayesian equilibrium outcome. In the equilibrium, one of the players proposes a menu that is optimal for the uninformed player among all menus, such that each type of the informed player receives at least her payoff under complete information. The optimal menu can be implemented with at most three allocations. Under a natural assumption on the uninformed player’s beliefs, the optimal menu coincides with the Myerson’s neutral solution to the bargaining problem in this environment. (JEL C78, D82, D83)
Knowledge and Educational Capital As Factors in the Formation of Intellectual Potential in the Context of the Modern Information Society
Authors: Scherbakov E. , Pudovkina O.
Published: May 2022

The article presents the issues related to the knowledge and educational capital of young people who, despite quality education and skills, often face difficulties in entering the labor market. The article reveals the essence and types of knowledge, distinguishes between information, knowledge and wisdom. A scheme of the educational development trajectory is proposed, taking into account the dual model of learning. The results of an empirical study conducted among students are presented, in the focus of which the process of creating educational capital is positioned. The authors have developed a methodological approach to the program for increasing the intellectual potential of students, built as an integral system of conceptual-target, content and analytical-effective components, aimed at personal transformation and new educational results, the content of which is determined by the supply of goals, meanings, values, priorities, way of thinking of the modern student.
Mixing Old Ingredients to Create a New Model for ‘Glocal’ Appreciative Inquiry Meetings
Authors: de Jong Joep C.
Published: May 2022

It was especially this wish to meet face-to-face again at what appears to be the end of the Covid 19 pandemic, at least in some parts of the world, that led to the idea of sending an invite to the European network to investigate the possibility of combining attendance of the Global AI Jam with a real face-to-face meeting.
Treatment of thread veins with intense pulsed light
Authors: Grove Jodie
Published: May 2022

Jodie Grove explores the treatment of thread veins using the well-established and common modality of intense pulsed light
Plume control in medical and cosmetic laser clinics: a practical guide
Authors: Town Godfrey , Murphy Mike
Published: May 2022

In this article, Godfrey Town and Mike Murphy review risk assessments that aim to control the dangers of plume and make recommendations that laser specialists can use to make their practice safe and secure
Quality improvement for patient safety and a better practice culture
Authors: Mosedale Pam , Turner Mark
Published: May 2022

This article explores the subjects of quality improvement, patient safety and practice culture, and the relationships between them. These subjects are highly relevant to the care that patients receive — learning more about them can improve our ability to treat animals effectively. A positive practice culture is one that encourages civility, teamwork, a blame-free attitude to errors, and a learning approach for the whole team. Quality improvement is a mechanism to improve standards of care — it helps patient safety and supports a positive practice culture. Quality improvement can be defined as the combined efforts of the whole team to make changes that will lead to better patient outcomes, better system performance (care) and better professional development (learning). Quality improvement methods, such as clinical audits and significant event audits, and quality improvement tools such as guidelines, checklists and systems of work, can help veterinary practices to make a start with quality improvement, and engaging with these quality improvement tools can help improve patient safety and practice culture to benefit all team members.
The role of energy and weight: from conception to adulthood
Authors: Burke Caroline
Published: May 2022

Growth represents a fundamental phase in a cat or dog's life and plays an important role in their life-long health. Energy intake influences not just bodyweight (both weight gain and loss), but also the rate of growth and even the success of reproduction. This article will take an in-depth look at the changing energy needs of cats and dogs from conception to adulthood and the role weight plays in supporting optimal growth.
Mask wearing in the veterinary practice
Authors: Sadler Emma
Published: May 2022

The clinical environment of a veterinary practice relies on personal protective equipment (PPE) for infection and biosecurity control, especially in areas such as the operating theatre room, dental suites and isolation wards. PPE places a barrier between staff and exposure risk and helps prevent the spread of pathogens between animals and staff. Before the COVID-19 pandemic, face masks were mainly required in clinical areas that posed the highest risk. However, as a result of SARS-CoV-2, the virus causing COVID-19, being spread by airborne transmission, face masks have been worn throughout all areas of practice, reducing the emission of the virus carrying particles when worn by an infected person. This article discusses the evidence-based research for the effectiveness of face coverings in the control of the spread of COVID-19. It also considers the social and psychological impacts to veterinary staff, clients and patients with doing so. Information on COVID-19 was gathered from government and scientific studies and research conducted by the Royal College of Veterinary Surgeons (RCVS) and Dogs Trust relating to the impacts of the COVID-19 pandemic on animals and veterinary nurses.
ANÁLISE RECENTE DA PRODUÇÃO CIENTÍFICA INTERNACIONAL SOBRE GESTÃO DO CONHECIMENTO: SCIENCEDIRECT – 2015 A 2019
Authors: Menezes Cassio Roberto Conceição de , De Santana José Ricardo
Published: May 2022

Este trabalho tem o objetivo de mapear a produção científica internacional sobre o tema Gestão do Conhecimento, identificando os artigos publicados em periódicos de acesso aberto pertencentes a base de dados ScienceDirect, no período de 2015 a 2019. A metodologia proposta tem como base a revisão integrativa de literatura, facilitando a compreensão do fenômeno e corroborando para novas concepções teóricas. Os principais resultados indicam que a maioria dos estudos associam a gestão do conhecimento ao desempenho organizacional e a sua aplicabilidade encontra apoio em diversos setores da economia, como o setor industrial, de serviços, agrícola e setor público, permitindo o intercâmbio entre algumas áreas – Administração Geral, Gestão de Pessoas, Tecnologia da Informação, Empreendedorismo, Meio Ambiente, Teoria Organizacional e inovação. Por fim, o trabalho parece reconhecer que a formação de uma tríade constituída pela gestão do conhecimento, inovação e propriedade intelectual vem sendo pouco explorada na literatura pesquisada.
Analisis Faktor yang Berpengaruh terhadap Waktu Survival Pasien Penyakit Ginjal Kronis menggunakan Uji Asumsi Proportional Hazard
Authors: Hamid Assyifa Lala Pratiwi , Subanti Sri , Susanti Yuliana
Published: May 2022

Chronic kidney disease is a disease whose risk of death is always increasing. This disease was ranked as the 13th leading cause of death in Indonesia in 2017. One of the successful managements of chronic kidney disease can be seen from the possibility of survival of patients with chronic kidney disease. To identify the probability of survival of an object, survival analysis is used. One method of survival analysis that can be used to determine the survival time of patients with chronic kidney disease is Cox regression. Cox regression must satisfy the proportional hazard assumption, where the ratio of the two hazard values must be constant with time. The graphical method, namely the log-log graph, can be used to test the proportional hazard assumption, but the results are only used as a provisional estimate. In this study, the goodness of fit test was used to test the assumptions by calculating the correlation between the Schoenfeld residuals and the survival time rank. In conclusion, the variables of hypertension and haemodialysis frequency meet the proportional hazard assumption.

Keywords: chronic kidney disease; Cox regression; goodness of fit; log-log graph; proportional hazard assumption
New Mathematical Properties of the Kumaraswamy Lindley Distribution
Authors: Mahommed Samy Abd Elmoez , Mohamed Salah M.
Published: May 2022

The Kumaraswamy Lindley distribution is a generalized distribution that has many applications in various fields, including physics, engineering, and chemistry. This paper introduces new mathematical properties for Kumaraswamy Lindley distribution such as probability weighted moments, moments of residual life, mean of residual life, reversed residual life, cumulative hazard rate function, and mean deviation. 

Keywords: Kumaraswamy Lindley distribution; probability weighted moments; residual  life; hazard rate; mean deviation
Pemodelan Kasus Kronis Filariasis di Indonesia Tahun 2019 Menggunakan Geographically Weighted Negative Binomial Regression (GWNBR)
Authors: Sinurat Sri Rahayu Yogyana , Pasaribu Ernawati
Published: May 2022

Filariasis is a mosquito-borne disease caused by filarial worms. In Indonesia, filariasis is the third most common vector-borne and zoonotic disease in the community. Patients who in the chronic stage will fell pain due to swelling and infection in the limbs so that it can ruin the daily activities, reduce work productivity and cause economic losses for both sufferers and the country. In 2019, there were 28 filariasis endemic provinces and only 6 non-endemic provinces. This shows that the treatment of filariasis has not been fully successful. This study aims to determine the general description of chronic cases of filariasis, identify spatial heterogeneity and analyze factors that influence the number of chronic cases of filariasis using GWNBR. The modeling results five provinces groups based on significant variables. Variables that have a significant effect in all provinces are the ratio of health facilities of 100,000 population, the percentage of regions with PHBS policies and the average humidity. Meanwhile, the significant variables in several provinces are the percentage of slum households, the percentage of poor people and the average air temperature.

Keywords: filariasis; overdispersion; spatial heterogeneity; negative binomial; GWNBR
Herpes simplex oesophagitis leading to perforation and mediastinal collection: a case report and review of literature
Authors: Moore E , Merali N , Abbassi-Ghadi N
Published: May 2022

Herpes simplex oesophagitis is rare, especially in immunocompetent patients. A 78-year-old man presented with sepsis on the background of several months of retrosternal chest pain and fatigue. Computed tomography of the chest abdomen and pelvis revealed a large mediastinal collection and an oesophago-gastro-duodenoscopy demonstrated a healed mucosal scar from a spontaneously healed perforation. The collection was successfully drained with an ultrasound-guided drain and the patient made a full recovery. Spontaneous oesophageal perforation from herpes simplex oesophagitis has been reported five times in the literature, with only two occurrences in immunocompetent individuals.
June 2022 Pulmonary Case of the Month: A Hard Nut to Crack
Authors:   University of Colorado, Aurora, CO USA, Gergen Daniel , Reihman Anne , Welsh Carolyn
Published: May 2022

No abstract available. Article truncated after 150 words. History of Present Illness: A 54-year-old man presented to clinic with chronic cough, dyspnea on exertion, unintentional weight loss, and night sweats. Seven months before, he developed dyspnea on exertion and symptoms did not improve with inhalers. Four months prior to presentation, he was treated for presumed community-acquired pneumonia of the right lower lobe. Neither symptoms nor chest radiograph improved with multiple courses of antibiotics. In the four weeks prior to presentation his symptoms progressed to the point that he was unable to walk in his house without significant dyspnea. Review of systems: 10-pound unintentional weight loss and six weeks of night sweats. Past Medical History, Social History and Family History: The patient had a 15-pack-year smoking history and quit 15 years prior to presentation. He had no other past medical history, surgical history, family history, nor medications. Physical Examination: Vital signs were normal on presentation. Physical exam showed faint …
Clinicopathological correlation of kidney disease in HIV infection pre- and post-ART rollout
Authors: Diana Nina Elisabeth , Davies Malcolm , Mosiane Pulane , Vermeulen Alda , Naicker Saraladevi
Published: May 2022

The spectrum of HIV-associated kidney disease has expanded significantly with the introduction of antiretroviral therapy (ART). In the pre-ART era there was prominence of HIV-associated nephropathy (HIVAN). More recently, the spectrum of disease additionally reflects comorbid illness in the ageing HIV population and ART-related nephrotoxicity. We performed a clinicopathological correlation of kidney disease in HIV-positive individuals who underwent kidney biopsy between 1989 and 2014, utilizing the 2018 Kidney Disease Improving Global Outcomes pathologic classification. ART rollout began in 2004 in South Africa. Patients biopsied pre-ART rollout were compared to those biopsied post-ART rollout with respect to demographics, clinical parameters and histology. We assessed kidney survival in a cohort of these patients following biopsy. Six hundred and ninety biopsies were included, 99 (14.3%) were undertaken pre- and 591 (85.7%) post-ART rollout. Most patients were of Black African descent (97.5%). The post-ART rollout patients were older (p = 0.007), had higher eGFR at presentation (p = 0.016) and fewer presented with eGFR of less than 15ml/min/1.73m2(p = 0.0008). There was a decrease in the prevalence of classic HIVAN (p = 0.00001); and an increase in FSGS (NOS) in the setting of HIV (p = 0.0022) and tubulointerstitial diseases (p = 0.009) post-ART rollout. Kidney function survival over 5 years was poorest in patients with classic HIVAN (p = 0.00005) and best in minimal change nephropathy (p = 0.0013). Kidney biopsy is crucial for the correct diagnosis and management of HIV-related kidney disease. ART rollout has shifted the spectrum of kidney disease away from classic HIVAN but has not eliminated it. Histological diagnosis prognosticates kidney survival.
Adalékok a 105 éve létrehozott harmadik pedagógia professzori állás betöltésének történetéhez
Authors: Donáth Péter
Published: May 2022

A dokumentatív elbeszélő tanulmány betekintést enged a 105 éve létrejött harmadik magyar, a pozsonyi egyetemi pedagógiai tanszékre történt pályázat históriájába: Kornis Gyula, Fináczy Ernő, Schneller István, Alexander Bernát játszmájába Imre Sándor és Weszely Ödön pozsonyi pályázatának elbírálása során, melyben pedagógiai, művelődés- és nemzetiségi politikai szempontok mellett természetesen személyi érdekek, motívumok is jelentős szerepet játszottak.
Differentiation between High Grade Glioma and Solitary Brain Metastasis Using Combined Diffusion-Weighted Imaging and Diffusion Tensor Imaging
Authors: Metwally Eman Soliman , Abdelaziz Tougan T. , Ekladious Mena E.Y. , Ayoub Ali Mahmoud
Published: May 2022

Background: High-grade gliomas (HGGs) and brain metastases (BMs) can display similar imaging characteristics on conventional MRI. In HGGs, the peritumoral edema is infiltrated by the malignant cells, which was not observed in BMs. Our study aims to determine whether the fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values could differentiate HGGs from BMs. Results: Twenty patients with provisional MRI diagnosis of high grade gliomas WHO grade III & IV versus metastatic brain tumors, examination was done on 1.5 tesla scanner, patients were divided into two groups based on pathology results, the fraction anisotropy (FA) was measured in the enhancing tumor parts and immediate peri-tumoral edema. The minimum and mean ADC in the enhancing tumor (ADCmin, ADCmean) and the minimum ADC in the peritumoral region (ADCedema) were measured from ADC maps. Values of FA and ADC measured in the peri-tumoral edema were significantly high in the metastatic than primary high malignant glial tumors, yet no significant differences in the values of FA and ADC measured in the enhancing tumor parts of the two groups. According to ROC curve analysis, a cutoff value of 0.119 for the FA measured in the peri-tumoral edema with sensitivity (100%) and specificity (75%) and a cutoff value of 1.7 x 10-3 for the ADCedema with sensitivity (87.5%) and specificity (75%) generated the best combination of for distinguishing between HGGs and BMs. Conclusion: FA and ADC values were found to distinguish between HGGs and solitary BMs. The peritumoral FA and ADC values are better than the intratumoral FA and ADC values in predicting the tumor type.
The Active Direct Torque Control of an Induction Motor based on an Artificial Neural Network
Authors: Mohammed Inas Jabbar
Published: May 2022

In this paper, a method is developed to control the induction motor IM using direct torque control (DTC), by means of artificial neural networks (ANN), in order to reach the optimum performance .And then using the MRAS technique, the desired and efficient control of the rotor speed could be estimated and achieved. The design uses the individual training technique with the fixed weight and the controlled models to avoid the difficult DTC calculation. A specific comparison analysis was conducted between both the control for direct torque neural networks (DTNNC) and conventional direct torque control (CDTC) applied to select voltage vector switching. The chassis was designed by Matlab / Simul for DTC.
Correlation between Development of Handwriting Skills and Cognitive Abilities in Primary School Children
Authors: Zakaria Aya , Salah Manal , Ali Mostafa S.
Published: May 2022

Background: Handwriting skills are the outcome of a multiplex integration of sensorimotor, cognitive, perceptual, visual, and sensory systems cooperating to complete a successful writing activity. Objective: To detect the relationship between the development of cognitive abilities and handwriting skills in primary school children. Methods: one hundred and fifty volunteer children with ages ranging from nine to eleven years, taught in the Arabic language as a primary language, right-handed children not suffering from any musculoskeletal problems or physical disabilities, with normal visual acuity even with eyeglasses participated in this study. Handwriting legibility was assessed using the handwriting legibility scale, and cognitive abilities such as verbal comprehension, perceptual reasoning, working memory, and processing speed were assessed using the Wechsler scale. Results: The results revealed that there was a weak positive non-significant correlation between handwriting skills and cognitive abilities (perceptual reasoning, verbal comprehension, working memory, and total score) while there was a weak negative non-significant correlation between handwriting skills and working processing speed. Conclusion: according to the current research results, there is a weak positive non-significant correlation between handwriting skills and the development of cognitive abilities in primary school children.
Preparation and Use of the Iraqi Nano Attapugite Induced by TiO2 for Decontamination Gas Oil (Diesel)
Authors: Mandeel Tariq Abdul Jaleel , Salem Jumaa W. , Hameed Abdul Adheem Zaily
Published: May 2022

In this paper, the use of nano particles of clay attapulgit be very effective. It is more effective than the use of Micro particles (μm 53) in the decontamination of oil (gas oil) for surface water cracker manner photo-degradation, using xenon lamps of long wavelength (200-800nm) in an atmosphere of oxygen as well as under an atmosphere of nitrogen for comparison purposes. The results of the photo-degradation molecules hydrocarbon long successful were followed using a Gas chromatography (GC) by reference to the standard models (Nonan C9H20, Dodecane C12H26, Hexadecane C16H34), and has been used spectroscopy (FT-IR) to follow changes in the locations groups effective. This study showed the possibility of decomposition of gas oil molecules using attapugite the long as supported and assistant surface to short chains using the rays of light similar to sunlight and then complete the short cracking natural sunlight later.
Study the Effects of Gamma Radiation on Nano Composite Material (Nano MgO): Image Analysis
Authors: Hameed Abdul Adheem Zaily , Al-Ani Muzhir Shaban , Khalaf Rafid Hamad
Published: May 2022

Recently, nanoparticles have been widely studied because of their efficient characteristics and wide range of applications. This paper aims to study the effects of exposure to gamma radiation on nanoparticles of magnesium oxide (Nano MgO). Different percentage weights 2%, 4%, 6% and 8% are used to prepare the templates. Many steps of image process procedure are applied for texture analysis. Range value, standard deviation value and entropy value are measure before and after gamma radiation exposure. The obtained results indicated that the samples of percentage weights 2% and 4% are more affected via gamma radiation exposure. On the other hand, the samples of percentage weights 6% and 8% are less affected via gamma radiation exposure.
External and Internal Reliability of Digital Indirect Bonding Technique Using Three Dimensional Models and Double Transfer Trays
Authors: Eissa Tarek Abdelmonem , Rifai Wael Mubarak , El-Shal Mohamed Gaber , Ibrahim Mohamed El-Sayed Saad
Published: May 2022

Introduction: Digital technology invaded all branches of orthodontics such as diagnostic aids, treatment planning, manufacturing of appliances and printing 3D models. there were many CAD programs to facilitate bracket placement more precisely and efficiently. there were many studies evaluated the efficacy and precision of digital indirect bonding approach and they found that it is effective strategy in general. However, there were limited research on the external reliability of digital indirect bonding approaches in literatures. Aim of the Study: To evaluate digitally the amount of discrepancy happened in bracket positions during transferring them by indirect bonding tray inside the patient’s mouth and external reliability of the measurements. Materials and Methods: Ten patients (4 males and 6 females), ranging from 15.9 to 23.4 years of age (mean 19.647 years, SD± 2.232), PVS impressions was taken for the upper arch of the patients and scanned by laboratory scanner to produce STL files to create digital models. digital indirect bonding of 100 American Orthodontic minimaster braces were performed on upper arch by positioning brackets on digital models using Ortho Analyzer (3Shape) software. Then, printing 3D model with braces and constructing the double transfer tray to be loaded with braces to bond it inside the patient’s mouth. After that, scanning of the bonded brackets was done by CEREC omnicam. Geomagic Control X software was used to measure the deviations happened in the bracket position on the patient’s mouth and the bracket position in Orthoanalyzer (3Shape) software. Results: Overall linear measurements were ranging from (-173.1±131.65 μm) to (200.2±132.86 μm). These deviations were related to occlusogingival and in-out directions and denoted to upper right first premolars and upper left canines respectively. Overall angular measurements were ranging from (0.51±0.03 degree) to (1.94±0.03 degree). These deviations were related to mesiodistal tip and denoted to upper right canines and upper left central incisors respectively. Discussion: The overall angular differences in the present study ranged from 0.51° to 1.94° and overall linear differences ranged from 0.1731 mm to 0.2002 mm, which agreed with those observed in the literature, confirming the reliability of the technique. Conclusion: Indirect bonding with a dual transfer tray can correctly replicate the position of brackets on digital models.
The Socio-economic and Environmental Impacts of Pentahelix Synergy in Tourism Empowerment: Insight from the Tourist Village of Rigis Jaya Coffee Village
Authors: Umaryani Tri
Published: May 2022

Collaboration and partnership with stakeholders in the Pentahelix concept as predictors can minimize negative impacts on tourism development. This article aims to describe socio-cultural, economic, and environmental realities in the development of Rigis Jaya Coffee Village tourism in developing tourism. The methodology of this research is qualitative using observation data, interviews, and documentation studies through FGDs. This research shows that the stakeholder's existence in Pentahelix collaboration is not only able to encourage economic growth, but also to preserve culture by presenting traditional dances and music and to increase environmental literacy so that good relations between humans and nature can be established. The synergy between ABCGM in the development of local tourism can be felt by the local community. This article is still limited to the scale of research in West Lampung, so it is still very possible to be completed by studies in other places with different scales and approaches.
Analysis of Rainwater Harvesting (RWH) Capacity in Leuwigajah Urban-Village, South Cimahi
Authors: Marselina Mariana , Choirunnisa Karina Indah , Nuralamsyah Ery , Nurhayati Siti Ai
Published: May 2022

Leuwigajah Urban-Village is an area belonging to Citarum Watershed. Thus, it has a high potential to experience floods during the rainy season. Meanwhile, the area often experiences drought during the dry season due to high surface runoff and low infiltration. This paper discusses the capacity of RWH needed in N.A. of R.W. 19. It discusses hydrological conditions of the Cimahi watershed by presenting an analysis of rainfall data, land use data, and extreme discharge data, both maximum and minimum extreme discharges. Therefore, the Citarum Harum Community Service team decided to build Rainwater Harvesting (RWH) as a water supply source during the dry season. The RWH was built based on people's water needs 10 years later, from 2022-to 2032. Based on the calculations explained in the Rainwater Storage Module book issued by the Ministry of Public Works and Housing, the volume of RWH needed is 125 m3. However, due to limited land, it was decided to build an RWH with dimensions of 2 m x 2 m x 2 m which can accommodate 8 m3 of water. The water in this RWH can fulfil 6.4% of daily water needs, so it is recommended to be used for emergency purposes or secondary purposes such as agriculture and plantations.
Application of Water Conservation Concept in X Apartment Bogor Regency
Authors: Wardhani Eka , Putri Windya Sefniza
Published: May 2022

The increase of population in Bogor Regency is directly proportional to the rapid development of residential building construction, one of which is apartment buildings. This resulted in the need for clean water also increased. Water conservation is an effort to maintain the availability of clean water in sufficient quality and quantity to serve the current and future needs of clean water. The application of the concept of water conservation in Apartment X in Bogor Regency can be done using WAC 2 (Water Fixtures) and WAC 3 (Water Recycle). Apartment X building has a building population of 998 people with daily clean water needs of 91,545 liter/day. The wastewater generated by the apartment building is 73,236 liter/day. It is estimated that the implementation of water conservation could save the use of clean water by 28.08% or around 25,701.42 liter/day.
Systematic Review: Noise Exposure Risks and Factors Associated with Hypertension Incidence in Workers
Authors: Arumdani Intan Sekar , Setiani Onny , Joko Tri
Published: May 2022

Noise is associated with hypertension. Exposure to noise that exceeds quality standards can cause an increase in workers' blood pressure. This study was conducted to examine the risk of noise exposure and the factors associated with the incidence of hypertension in workers through a systematic review method. Article searches were conducted through the journal sites Google Scholar, Garuda Portal, Science Direct, Proquest, JSTOR, Scopus, Semantic Scholar, and PubMed. The selection of articles was carried out with the following criteria: the dependent and independent variables were the incidence of hypertension in workers and exposure to noise, open access full text, the articles selected were articles with a publication date of not more than 10 years (2012-2021), and articles in English. Indonesian and English. Based on 724 relevant articles, 9 main articles met the criteria and were discussed further in this study. 9 main articles showed statistical test results p-value <0.05 which means there is a significant relationship between noise exposure and the incidence of hypertension in workers. Other factors, namely age of workers, length of work, gender, use of ear protective equipment, BMI, and family history of hypertension all have a significant relationship with the incidence of hypertension.
The Determinant of Environmental Disclosure in ASEAN Countries
Authors: Wahyuningrum Indah Fajarini Sri , Safitri Lisdiana , Oktavilia Shanty , Setyadharma Andryan
Published: May 2022

The purpose of this study is to examine the effect of firm size, industry type, profitability, firm age, environmental performance, institutional ownership, and gender diversity on environmental disclosure. The quantity of environmental disclosure is measured using disclosure scoring by giving “1” for items disclosed and “0” for items that are not disclosed. The population used in this study are manufacturing companies listed on the Indonesia Stock Exchange (IDX) and Kuala Lumpur, Stock. Exchange (KLSE) in the year 2019. The sampling technique used was purposive sampling which resulted in 74 companies. The analytical technique used in this research is multiple linear regression analysis using IBM SPSS Statistics version 25. The results of this study indicate that company size, company age, and environmental performance have a significant positive effect on environmental disclosure. The type of industry, profitability, institutional ownership, and gender diversity does not affect environmental disclosure. Based on the study results, it can be concluded that companies that are large in size and mature in age and equipped with ownership of ISO 14001 certification can contribute to making more comprehensive environmental disclosures.
Assessment of Settlement Quality Levels in Balikpapan Kota Subdistrict, Balikpapan, Indonesia
Authors: Ulimaz Mega , Pratama Reynaldi Yudha , Dewanti Ajeng Nugrahaning , Syafitri Elin Diyah
Published: May 2022

Balikpapan is experiencing rapid urbanization and has an essential role in settlement development. One of the strategic issues of settlements in Balikpapan is the settlements that have decreased in quality in residential in urban areas with a mild level of slum. Based on the Balikpapan Spatial Plan, the spatial pattern in the Balikpapan Kota Subdistrict is dominated by the Settlement Area. It can be said that the components of settlements are the components that are planned to support settlement activities. Therefore, it is necessary to assess the quality of settlements in the Settlement Area in the Balikpapan Kota Subdistrict. The analysis was carried out by quantitative descriptive method (scoring method) with the unit of study for each settlement block or neighborhood. The analysis results of the quality of settlements in the Balikpapan Kota Subdistrict tend to have reasonable quality settlements. There were no areas that had poor settlement quality values. In the research area, from 131 neighborhoods, 19 neighborhoods still have a moderate quality of settlements. It is necessary to increase several components to improve the quality of settlements in each block so that all settlements become more liveable.
Study of Desiccation Crack Behavior of Fly Ash - Bentonite (FAB) Composite in Landfill Liner System
Authors: Yohana Eflita , Syafrudin Syafrudin , Budihardjo Mochamad Arief , Ramadan Bimastyaji Surya , Lantasi Ayudya Izzati Dyah , Muhammad Fadel Iqbal , Humaira Natasya Ghinna
Published: May 2022

The addition of bentonite to fly ash can lower the permeability coefficient of the composite landfill liner. Also, the montmorillonite bentonite can bind quite a lot of water molecules during the hydration process. In this study, the effect of mixture, water content, and salinity on the desiccation cracking phenomenon in the bentonite - fly ash mixture as a landfill liner system was investigated by conducting tests such as desiccation test, water content test, and standard proctor and permeability test. The variation in bentonite levels: 0%, 15%, 20%,25% and 25% + 1 N NH4Cl solution. The result shows that the appropriate mixture is fly ash + 15% bentonite with permeability of 4,065 x 10-7. The mixture complies with local regulations where the permeability coefficient of the bottom layer of the landfill should be less than 10–6 cm/s and have a low cracking value (CIF). Furthermore, the addition of saline solution to the composite can rise the value of the optimum moisture content. However, saline conditions can decrease the value of CIF drastically
Utilization of Bottom Ash as an Adsorbent for Color and COD Removal for Textile Industry Waste
Authors: Fadilla Pricilla Jihan , Sururi Mohamad Rangga , Marganingrum Dyah , Dirgawati Mila
Published: May 2022

This study investigates the use of bottom ash as an adsorbent with and without chemical activation treatment. This study also determines the effect of pH and stirring speed on the efficiency of bottom ash in the adsorption of color and COD. Bottom ash was ground and sieved by 100 mesh sieves and was activated by hydrochloric acid 2%. The experiments were conducted at pH variations of 6, 8, 10; contact time variations of 30, 60, and 90 minutes; and stirring speeds of 30 and 60 rpm. The most effective adsorption by non-activated adsorbents occurred at the combination of pH six and stirring speed of 60 rpm with the removal efficiency for color 66.30% at a contact time of 90 minutes and for COD 31.55% at a contact time of 30 minutes. While for activated adsorbent, the highest removal for color (77.44%) and COD removal (40.54%) were at pH 6, stirring speed 30 rpm, contact time 30 minutes. The bottom ash was potentially used as an adsorbent for treating wastewater containing high concentrations of color and COD.