bluuebunny/crossref_metadata_2025 huggingface dataset:
La relación museo-escuela en la formación inicial de profesores
Authors: Soto-Lombana Carlos Arturo , Angulo-Delgado Fanny
Published: January 2025

El uso de los museos como medio didáctico para la enseñanza de las ciencias está documentado en la literatura especializada; no obstante, son pocos los estudios que registran experiencias de formación inicial de profesores que integran los museos como parte de un dispositivo formativo integrado al desarrollo de prácticas pedagógicas finales de carrera. El objetivo de la investigación fue conocer cómo un grupo de profesores perciben, recuerdan y dan sentido a una experiencia de formación docente en el contexto de las prácticas pedagógicas realizadas en el marco de la relación museo-escuela. El método de análisis temático, en el enfoque fenomenológico adoptado, resalta la comprensión del museo como un espacio educativo distinto al escolar, con potencial para promover otros aprendizajes y como espacio de ejercicio profesional. Asimismo subraya el carácter innovador de la relación museo-escuela, ligado a la comprensión de las implicaciones de la visita para el docente visitante, su grupo de estudiantes, las practicantes y los educadores del museo.
Conocimiento didáctico del contenido, un constructo conceptual relevante en la enseñanza de las ciencias básicas
Authors: Campos-Nava Marcos , Torres-Rodríguez Agustín Alfredo
Published: January 2025

En esta revisión, se describen las características que han posicionado al constructo conceptual denominado Conocimiento Didáctico del Contenido (CDC) como una poderosa herramienta teórico-metodológica que permite identificar la naturaleza de los conocimientos base para la enseñanza de las ciencias básicas. Se describen asimismo diferentes aproximaciones que fueron robusteciendo su definición conceptual, para dar paso posteriormente a su análisis y desglose en componentes o sub-dimensiones que permitieron desarrollar metodologías para su cuantificación como variable operativa, no sin advertir que su medición resulta un tanto compleja debido a la naturaleza misma del constructo. Ambas descripciones, como concepto y variable, han potenciado su relevancia como un constructo que puede incidir fuertemente en los conocimientos que un profesor de ciencias puede desarrollar para mejorar su enseñanza, además de proveerle de un marco teórico-metodológico para su actualización profesional y docente
Mapeando as integrações dos componentes do conhecimento pedagógico do conteúdo: um estudo com licenciandos de Química no programa de residência pedagógica
Authors: Fernandes Goes Luciane , Fernández Carmen
Published: January 2025

Este estudo investiga as inter-relações entre os componentes do Conhecimento Pedagógico do Conteúdo (PCK) de licenciandos em Química participantes do Programa de Residência Pedagógica (PRP). Adotou-se uma abordagem qualitativa de estudo de caso, envolvendo a implementação de sequências didáticas, reuniões semanais e análises de relatórios semestrais. Entrevistas semiestruturadas foram utilizadas com base na técnica de reflexão estimulada, a fim de explorar e discutir o planejamento e a execução das atividades de intervenção. Os dados foram analisados por meio de análise temática qualitativa e organizados com base nos cinco componentes do PCK. Os resultados indicaram uma forte integração entre as Orientações para o Ensino de Ciências e o Conhecimento de Estratégias Instrucionais, além de uma conexão significativa entre o Conhecimento da Compreensão dos Alunos e o Conhecimento de Estratégias Instrucionais. Em contrapartida, o Conhecimento do Currículo de Ciências revelou uma integração mais limitada. O estudo também permitiu a observação direta do ePCKe do pPCK, bem como o impacto do PRP no fortalecimento do pPCK e do cPCK. Esses achados destacam a relevância desses componentes tanto na prática docente quanto na formação inicial de professores.
SUSTENTABILIDADE SOCIOECONÔMICA E AMBIENTAL EM QUINTAIS PRODUTIVOS (QP) NA ILHA DE CARATATEUA, BELÉM/PA: DESAFIOS E OPORTUNIDADES
Authors: Lopes Sara Cardoso , Vasconcelos Marcelo Augusto Machado , Souza Aletéia Patrícia Vilhena de , Soares Rodrigo Souza , Bulhões Clever Cley Correa , Santos Artur Vinícius Ferreira dos , Bittencourt Paulo Celso Santiago , Silva Osmar Guedes da
Published: January 2025

O artigo sobre a sustentabilidade socioeconômica e ambiental em Quintais Produtivos (QP) tem demonstrado um avanço significativo ao longo das últimas décadas, refletindo a crescente importância desses espaços para a agricultura familiar. Esse progresso pode ser atribuído à integração de abordagens teóricas robustas e metodologias inovadoras, como o uso de Sistemas de Informação Geográfica (SIG) e a Análise Regressiva Socioeconômica e Ambiental (SEA).  A pesquisa foi realizada in loco e desenvolvida na Ilha de Caratateua pertencente a Região Metropolitana da Amazônia Paraense (RMB). Os resultados apontam dez (10) atributos analisados:  renda e sustentabilidade econômica, segurança alimentar e nutricional, educação e capacitação, acesso a mercados e comercialização, participação comunitária e social, empoderamento feminino, conservação da biodiversidade, práticas de manejo sustentável e impacto ambiental  e foram os que tiveram acréscimos e, que apenas o acesso à recursos e políticas públicas não obteve alteração, se mantendo constante no decorrer do período analisado.O Índice Socioeconômico e Ambiental  revelou um avanço significativo no período de 2019 a 2024 subindo de 0,63 para 0,93 indicando um aumento de 47,62% na sustentabilidade dos QPs. Coclui-se que QPs na Ilha têm impacto positivo significativo na segurança alimentar, na economia local e na sustentabilidade ambiental mais carecer de apoio para expandir as práticas produtivas para promover um desenvolvimento sustentável e melhorar a qualidade de vida da comunidade.
Rare Occurrence of Bastnaesite, Yttro-columbite and Chevkinite from Podili Granite, Prakasam Alkaline Province within Nellore Schist Belt, Southern India: Insights from Field, Petrography, Geochemistry and Mineral Chemistry
Authors: Biswas Ankita , Banothu Venkanna , Chandramouleeswara Rao K.
Published: January 2025

This work reports the occurrence of Bastnaesite, Yttro-columbite, and Chevkinite for the first time from Podili alkali pluton, Andhra Pradesh. Podili granite is an A-type Mesoproterozoic alkali granite situated within the Prakasam Alkaline Province (PAP), emplaced within the Neoarchaean Nellore schist belt (NSB) towards its northern part. Petrography, SEM-EDS and Electron Probe Micro Analyser (EPMA) confirm the occurrence of bastnaesite [Ce, La (CO3) F] as discrete euhedral hexagonal crystal forming at the interstitial spaces of plagioclase feldspar at times, indicating its magmatic origin. Yttro-columbite [Y(Fe)Nb2O] occurs as inclusion within the zircon. Chevkinite [Ce, Nd, Ca)4Fe)2(Ti, Fe)3Si4O22] appear as euhedral grains disseminated in the feldspar-rich matrix. The presence of bastnaesite, yttro-columbite and chevkinite is responsible for the enrichment of ΣLREE (Max.1645ppm) over ΣHREE (Max.129ppm) in Podili syenite evolved through volatile enriched Podili alkali granite. Enrichment of fluorocarbonate bastnaesite indicates the presence of halogen F- in the melt, which substitutes hydroxyl ion (OH-) and facilitates late-stage REE mineral crystallisation. The halogen-bearing late-stage injection of CO2-rich melt affected the initial volatile enriched host alkali granite that evolved the granite and enriched the pluton with the LREE-dominated fluorocarbonate with significant REE mineral precipitation due to fluid-rock interactions.
First report of the Uvigerinids of the Central Equatorial Indian Ocean
Authors: Vijay Puja , Nisha Neelakantan Ravindran
Published: January 2025

The Central Equatorial Indian Ocean (CEIO) is known for its cross-basin exchange since it is influenced by both southwest and northeast monsoon. The present investigation is the first report of the Uvigerinids of CEIO. Here, we document the complex morpho diversity of Uvigerinids and propose a classification based on surface ultrastructure. The twenty seven Uvigerinid species were recorded through the present study and sixteen of them are reported for the first time from the CEIO. The recorded new species are Uvigerina rustica, U. ampullacea aff. auberiana, U. farinosa, U. mantaensis, Siphouvigerina ampullacea aff. aculeata, Siphouvigerina pseudoampullacea, U. lappa, Uvigerina aff. mexicana, U. macrocarinata, U. tumeyensis, U. cubana, U. cocoaensis, U. continuosa, U. flintii, U. semiornata urnula, Hopkinsina shinboi. Based on the various morpho classifications available for Uvigerinids from the World Oceans, we propose to classify the recorded Uvigerinids into hispid-spinose, spinose-pustulous, spinose-costate, serrate-costate, platy-costate, and miscellaneous species. The distribution pattern of Uvigerinids in the study area suggests the CEIO exhibits moderate to high productivity, upwelling and is significantly influenced by glacial-interglacial cycles. This preliminary investigation suggests that CEIO can be a unique area to investigate the evolutionary trajectory of Uvigerinids from the Tertiary period to Recent times.
REE-Mineralization in the Ankeritic Carbonatite Vein in Sövite in Amba Dongar, Gujarat, India
Authors: Viladkar Shrinivas G.
Published: January 2025

Sövite and ankeritic carbonatite are the main source of rare earth elements in the Amba Dongar carbonatite complex. The mineralogy and mineral chemistry of a single vein of ankeritic carbonatite invading sövite is presented. Along with REEminerals – bastnäsite and synchysite, apatite, pyrochlore, barite and carbonates are also analyzed.
USDA ARS Long-Term Agroecosystem Research (LTAR) Common Experiment v1
Authors: J. Abendroth Lori , A. Liebig Mark , Philip Robertson G
Published: January 2025

A component of the USDA ARS Long-Term Agroecosystem Research (LTAR) network is a Common Experiment standardized across all sites. This collection contains all standardized protocols for the biophysical metrics collected in the Common Experiment.
Protocolo de Uso do Isolera-Biotage para "Wide-Polarity-Range" (WPR) v2
Authors: M. Borges Ricardo
Published: January 2025

Este protocolo descreve o procedimento para fracionamento de misturas complexas utilizando o método Wide-Range-Polarity (WRP) no sistema Isolera-Biotage. Esse método emprega um gradiente de eluição controlado para separar compostos com ampla variação de polaridade, como metabólitos secundários de extratos naturais. O método é aplicável para colunas de fase estacionária de sílica gel ou C18, dependendo das características da amostra. English: This protocol describes the procedure for fractionating complex mixtures using the Wide-Range-Polarity (WRP) method on the Isolera-Biotage system. This method employs a controlled elution gradient to separate compounds with a wide range of polarity, such as secondary metabolites from natural extracts. The method is applicable to silica gel or C18 stationary phase columns, depending on the sample characteristics.
Jogos educativos para melhorar letramento em saúde de pessoas com diabetes: protocolo de scoping review
Authors: Silva Erielton Gomes da , Silva Alex dos Santos , Santos Suenny Alves dos , Matias Lucas David Maia , Moreira William Caracas , Santos Carla Lidiane Jácome dos , Silva Rute Xavier , Andrade Lidiane Lima de
Published: January 2025

Objetivo: Mapear jogos educativos para auxiliar no letramento em saíde de pessoas que vivem com DM tipo 2 para melhorar o autocuidado. Método: Protocolo guiado pelo Joanna Briggs Institute, com questão de pesquisa elaborada com PCC: População (Pessoas que vivem com diabetes mellitus tipo 2); Conceito (Jogos educativos para auxiliar na melhora do Letramento em Saúde); e Contexto (Empoderamento para o autocuidado), gerando: “Quais jogos educativos podem ser utilizados para auxiliar a melhora do LS e empoderar pessoas com DM tipo 2 quanto ao autocuidado?”. A busca será realizada na PubMed, Scopus, LILACS, Information, Science & Technology, Google Scholar, Catálogo de Teses e Dissertações da CAPES e Repositórios Científicos de Acesso Aberto de Portugal. A seleção dos artigos será em duas etapas, com dois pesquisadores e outro revisor para resolução de conflitos, utilizando o software Rayyan. A extração dos dados dar-se-á por um formulário adaptado do JBI. A análise será descritiva e os resultados serão expostos por fluxogramas, quadros e/ou tabelas. Resultados esperados: Os jogos poderão ser estratégias lúdico-educativas para trabalhar com pessoas que vivem com DM tipo 2, melhorando autocuidado. Os achados podem evidenciar lacunas existentes. Conclusão: Os achados servirão como subsídio ao tratamento não-farmacológico, melhorando autocuidado dessa população.
Achieving the Sustainable Development Goals through Financial Inclusion: A Bibliometric and Content Analysis
Authors:   Central University of Himachal Pradesh (CUHP), School of Commerce and Management Studies (SCMS), HPKVBS, India, Chandel Monika , Arora Manpreet ,   Central University of Himachal Pradesh (CUHP), School of Commerce and Management Studies (SCMS), HPKVBS, India
Published: January 2025

This article presents a bibliometric study that explores the connections between the literature on achieving Sustainable Development Goals (SDGs) through financial inclusion using a relational approach. The findings highlight key publication trends, the most prolific countries, leading contributors, highly cited articles, and the most impactful journals in this field. Additionally, content analysis reveals four emerging areas of research: “financial technology and SDGs,” “social capital,” “microfinance and women empowerment,” and “green finance.” Based on these insights, the study recommends that managers prioritise adopting digital technologies to foster financial inclusion, build robust networks to enhance resilience, empower women through tailored financial products, and integrate the Sustainable Agenda 2030 into financial strategies. Organisations can promote inclusion, resilience, and sustainable growth by aligning with these evolving research domains while advancing the SDGs. The results aim to inspire and guide management and economic researchers toward achieving the SDGs and serve as a foundation for realising Agenda 2030 objectives.
Clinical outcomes of fractional erbium laser therapy in the treatment of mucosal lichen planus
Authors: Akhter Farjana , Uddin M. Rokon , Al Faisal Abdullah
Published: January 2025

Introduction: Lichen planus is a chronic inflammatory condition affecting the skin and mucous membranes, with a prevalence of 1% to 2.2% in the general population. This study aims to evaluate the clinical outcomes of fractional erbium laser therapy for mucosal lichen planus, focusing on its efficacy in relieving symptoms and improving quality of life. The aim of the study was to evaluate the clinical effectiveness and safety of fractional erbium laser therapy in treating mucosal lichen planus.
Methods: This prospective observational study took place in the Department of Dermatology at Bangladesh Specialist Hospital, Dhaka, Bangladesh, from March 2021 to February 2023, involving 30 patients with mucosal lichen planus. Participants provided informed consent, and their lesion severity was assessed prior to administering fractional erbium laser therapy. Outcomes were measured and analyzed using SPSS version 22.0.
Result: Participants had a mean age of 58 ± 8.6 years, with 96.67% being female. After fractional erbium laser therapy, 90% achieved complete remission, and 83.33% reported no side effects. Pain scores dropped from 7.0 ± 1.5 to 2.3 ± 1.2, while lesion size decreased from 3.8±0.8 cm² to 1.0±0.5 cm². Satisfaction was high, with 80% highly satisfied, and follow-up indicated a 66.67% no recurrence rate of lesions.
Conclusion: Fractional erbium laser therapy is an effective and safe treatment for mucosal lichen planus, showing high remission rates, minimal side effects, and patient satisfaction.
Comparing the frequency of anemia in rheumatoid arthritis and axial spondyloarthritis patients and its relationship with hemogram parameters
Authors: Yilmaz Ebru , Pasin Özge
Published: January 2025

Background: To compare the frequency of anemia in rheumatoid arthritis (RA) and radiographic axial spondyloarthritis (r-axSpA) patients and to investigate its relationship with hemogram parameters used as inflammation markers.
Methods: The study included 87 RA patients and 116 r-axSpA patients. Characteristics of the patients, hemogram parameters (neutrophil-lymphocyte ratio 'NLR', platelet-lymphocyte ratio 'PLR', systemic immune-inflammation index 'SII', red blood cell distribution width 'RDW' and mean platelet volume 'MPV'), laboratory parameters (erythrocyte sedimentation rate 'ESR' and C-reactive protein 'CRP') and indices (Disease Activity Score in 28 Joints (DAS-28) for RA and the Bath Ankylosing Spondylitis (AS) Disease Activity Index (BASDAI) and AS Disease Activity Score with CRP (ASDAS-CRP) for axSpA) were recorded.
Results: The mean age for RA and r-axSpA patients was 55.8±12.0 and 43.8±10.1 years.  Anemia was present in 47.1% of RA patients and 31.9% of r-axSpA patients and more prominent in RA patients (p=0.030). There was a significant female gender superiority in those with anemia in r-axSpA patients (p<0.001). ESR, PLR, SII and RDW values were significantly higher in patients with anemia in the RA (p=0.002, p=0.048, p=0.035, p<0.001, respectively), whereas only ESR was significantly greater in patients with anemia in the r-axSpA (p=0.012). There was no significant difference between disease activity and anemia in both disease groups.
Conclusions: Although the frequency of anemia was not affected by disease activity, female gender involvement was prominent. The increase in ESR and RDW values may reflect the possibility of developing anemia in rheumatic diseases.
Medical students’ perception of the use of artificial intelligence in medical education
Authors: Wobo Kiniyiruchi Nelson , Nnamani Ifeoma Ogonna , Alinnor Ezioma Anne , Gabriel-Job Nneka , Paul Nsirimobu
Published: January 2025

Background: Artificial Intelligence (AI) refers to technology that can efficiently perform tasks that typically require human intelligence, such as decision-making, teaching, object detection, and solving complex problems. As a veritable tool in medical education, this study was conducted to assess medical students’ awareness, perception and usage of AI in learning.
Methodology: This study was conducted at the Department of Paediatrics, University of Port Harcourt Teaching Hospital (UPTH). The subjects were one hundred and thirty-nine 5th-year medical students who had completed 3 months of Paediatrics and Obstetrics/Gynaecology clinical rotations. Data was collected using a semi-structured, open-ended questionnaire. Data were analysed using IBM SPSS Statistics version 26. Statistical significance was set at p value<0.05.
Results: 64 (46%) of the respondents are aware of AI. 57 (44%) of respondents applied AI during their clinical training. The most commonly used AI tool is Chatbots. 57(100%).  The major limitations to AI use were unreliable internet connectivity (62%) and the high cost of AI hardware and software (53%). Most respondents (68%) expressed ethical concerns about the use of AI. There was a statistically significant relationship between awareness of AI and the use of AI in learning (p=0.0001)
Conclusion: This study demonstrates average awareness of AI's use and benefits among medical students. The major limitations to using AI were unlimited internet connectivity and the cost of AI tools. To maximize the benefits of AI in medical education in developing countries, medical schools need to increase their awareness and infrastructural capacity.
Prevalence, risk factors and management approaches for seborrheic dermatitis
Authors: Islam M. Shahidul , Islam Nahida , Azad Khan M. Abul Kalam , Hasan A. H. M. , Rani Saha Kamana , Happy Moon Renaissance , Begum Maksuda , Rubana Sadia
Published: January 2025

Background: Seborrheic dermatitis (SD) is a chronic inflammatory condition characterized by immune dysregulation, inflammation and disruption of the skin barrier. Despite its global prevalence, with studies indicating that up to 5% of the population may be affected, the study of the physical and emotional impact of SD on patients is limited. Furthermore, the prevalence of SD appears to be increasing over time. Therefore, this study aimed to determine the prevalence, risk factors and management approaches for seborrheic dermatitis.
Methods: This was a prospective study conducted in the Department of Skin and VD, Community Based Medical College Bangladesh, Mymensingh, Bangladesh during the period from June 2020 to June 2022. In our study, we included 150 patients with seborrheic dermatitis who visited the Department of Skin and VD at Community Based Medical College Bangladesh.
Results: Among 150 patients, 55% were male and 45% were female. Among all reported patients, 56 (71%) had a moderate level of SD, followed by mild (16%) and severe (13%). Among the HCP (Health care provider) suggested patients, 41% of them had moderate SD, followed by mild (40%) and severe (19%). Out of 150 patients, 50% of them were not allowed to miss their jobs due to the symptoms.
Conclusions: The findings of this study highlight the importance of a holistic care approach for managing seborrheic dermatitis. This approach should encompass not only the treatment of the physical signs and symptoms of the disease but also the psychological and social challenges that patients with seborrheic dermatitis face.
Effect of total body fat on blood pressure in adolescents
Authors: Ansari Aaqib Husain , Singh Shraddha , Ghildiyal Archna , Paisal Aman , Mani Chandra
Published: January 2025

Background: Hypertension is a growing health concern among adolescents, with rising prevalence demanding a deeper understanding of its causes. Anthropometric factors are potential contributors to blood pressure variations, but their relationship with adolescent blood pressure remains unclear.
Methods: A cross-sectional study of 110 adolescents at King George's Medical College, Lucknow, from 20th June 2023 to 1st March 2024, examined the link between anthropometric parameters and blood pressure. Measurements followed standard protocols, and statistical analysis included correlation, linear regression, and multivariate methods.
Results: Participants averaged 15.98 years, with mean height, weight, and BMI of 164.92 cm, 61.98 kg, and 22.48 kg/m². Diabetes history was reported in 23.64%, and 27.27% had hypertension. Average waist and hip circumferences were 84.49 cm and 93.43 cm, with body fat at 21.33%. Mean systolic and diastolic pressures were 120.36 mmHg and 77.15 mmHg, with 9.09% showing elevated blood pressure. Males had higher physical measurements and systolic pressure, while females had higher body fat. Systolic pressure correlated with age, size, and BMI, while diastolic pressure linked to weight, BMI, and body fat.
Conclusions: Body measurements and fat levels significantly impact adolescent blood pressure. Higher body fat, waist circumference, and weight are linked to increased diastolic pressure, while systolic pressure correlates with age, height, and body size. Males tend to have higher systolic pressure and physical measurements, while females show higher body fat percentages. These findings highlight the importance of monitoring body composition to prevent hypertension and reduce cardiovascular risks in adolescents.
Study of serum uric acid level in chronic liver disease and its association with hepatic encephalopathy and LFT parameters
Authors: Gupta Atul , Kumar Vinay , Singh Mahendra Pal , Giri Richa
Published: January 2025

Background: Chronic liver disease (CLD) is a progressive condition associated with complications such as hepatic encephalopathy (HE), a neuropsychiatric manifestation linked to altered purine metabolism and serum uric acid (SUA) levels. While liver function tests (LFTs) evaluate liver health, the role of SUA in CLD, particularly its correlation with HE severity and LFT parameters, remains underexplored. To investigate serum uric acid levels in CLD patients and examine their correlation with HE severity and LFT parameters.
Methods: This cross-sectional study included 54 CLD patients aged 18-85 years from GSVM Medical college Kanpur, selected via random sampling. Clinical and biochemical data, including SUA levels and LFTs, were collected and analysed. Statistical analyses using ANOVA and Pearson correlation assessed associations between SUA, HE grades, and LFT parameters.
Results: Serum uric acid levels significantly correlated with HE severity (ANOVA: F=6.93, p<0.05), with mean SUA levels rising from 6.28 mg/dL in Grade 0 to 10.41 mg/dl in Grade 2 HE. SUA demonstrated significant negative correlation with serum albumin (r = -0.36, p<0.05) and positive correlations with PT-INR (r = 0.33, p<0.05) and creatinine (r = 0.55, p<0.05). No significant correlation was observed with bilirubin, SGOT or SGPT.
Conclusions: Elevated SUA levels are significantly associated with the severity of hepatic encephalopathy and key LFT parameters. SUA may serve as a valuable biomarker for assessing CLD progression and predicting complications like HE.
Prognostic role of serum uric acid levels in patients with decompensated chronic heart failure
Authors: Sharma Salvi , Priyadarshi Basudev Prasad , Sachan Mohit
Published: January 2025

Background: Chronic heart failure (CHF) affects over 26 million people worldwide and is characterized by the heart’s inability to meet the body’s metabolic demands due to structural or functional abnormalities, resulting in high morbidity and mortality. Traditional biomarkers such as sST2, cardiac troponin, and natriuretic peptides are costly and not universally accessible, creating a need for affordable and accessible alternatives.
Methods: This study evaluated the prognostic role of serum uric acid levels in decompensated CHF by comparing outcomes such as hospitalization duration, ICU stay, and mortality between patients with high (>7 mg/dl) and low (≤7 mg/dl) uric acid levels. Conducted over 14 months at K.P.S. Post Graduate Institute, GSVM Medical College, Kanpur, the study included 126 patients selected through purposive sampling. Data collection involved physical exams, laboratory tests, echocardiography, and ECGs.
Results: Elevated serum uric acid levels were associated with reduced ejection fraction, prolonged hospital and ICU stays, and worse cardiac function. Patients with higher uric acid levels demonstrated poorer clinical outcomes, highlighting its potential role in risk stratification and prognosis.
Conclusions: Serum uric acid is a valuable, low-cost prognostic marker for CHF, offering potential utility in early diagnosis and management. Its incorporation into clinical practice could improve outcomes and facilitate timely, affordable interventions, addressing the growing global burden of CHF. These findings underscore the need for further research to explore its integration into clinical workflows.
Incidence of homologous recombination deficiency among high grade serous ovarian carcinoma patients from a tertiary care center in India
Authors: Goswami Uddiptya , Ray Vedanta , Ananthakrishnan Ramya , Jayaraman Kumanan , Mohapatra Subhadarsini , Thirumalairaj Raja
Published: January 2025

Background: Ovarian cancer (OC) is the 9th most prevalent cancer overall in India and the 3rd most common among women, following breast and cervical cancers. According to GLOBOCAN 2022, there were 47,333 new OC cases and 32,978 deaths. Epithelial ovarian cancer (EOC) represents 90% of OC cases, of which 70% are high-grade serous ovarian cancer (HGSOC). Unfortunately, most patients are diagnosed at advanced stages III-IV. Homologous recombination deficiency (HRD) is a phenotype that is characterized by the inability of a cell to repair DNA double-strand breaks using the HRR pathway, leading to genomic instability and further malignant transformation. The Cancer Genome Atlas (TCGA) has reported HR deficiency in nearly 50% of HGSOC cases.
Methods: This retrospective observational study evaluated 62 HGSOC patients treated at Apollo Cancer Centre Chennai from January 2021 to January 2024. Clinical data were collected from medical records. Formalin-fixed, paraffin-embedded (FFPE) tissue samples were obtained from patients undergoing surgery or biopsy and tested for HRD status. The data was analyzed and represented.
Results: In the study population of 62 patients, 15 patients (24%) had HR deficiency (HRD positive).8 (13%) patients had poor quality FFPE tissue. Out of the 15 HRD-positive patients, six patients were TBRCA1, and four patients were TBRCA2. Five patients had GSS of more than 42.
Conclusions: There is a significant population of HR-deficient HGSOC, comparable with the published literature. Thus, it serves as a predictive biomarker in ovarian cancers with deficiencies in DNA repair mechanisms.
Comparative study on the effectiveness of case-based learning over small group discussion in pediatrics among 8th semester MBBS students
Authors: G. S. Bindu , Vijayan Sini
Published: January 2025

Background: Case based learning (CBL) is a new teaching learning method in medical education. The goal of this method of teaching is to prepare students for clinical practice through the use of authentic clinical cases. It links theory to practice through the application of knowledge to the cases. Hence it is effective for students who have already acquired foundational knowledge. The study was conducted to compare CBL and the traditional method of small group discussion (SGD) in Pediatrics among 8th semester MBBS students.
Method: This quasi-experimental study was done among 8th semester MBBS students (n=83) of Government Medical College in south Kerala. The students were divided into two groups. One group was taught by CBL and the other by SGD. Pre-tests containing 10 multiple choice questions were conducted prior to each session. After three sessions, they were crossed over so that the two groups were exposed to both types of teaching learning methods. Post tests were conducted after 3rd (post test1) and 6th (post test2) sessions and the results were analysed.
Results: There was no statistically significant difference in the post test scores between CBL and SGD groups (p value 0.696 for post test1 and p value 0.908 for post test2). However, the learners agreed that CBL had helped them in making concepts clear, stimulated active learning and improved their skills in case analysis.
Conclusion: CBL can be used as a teaching learning method in Pediatrics to complement the traditional methods of teaching like SGD.
The impact of artificial intelligence in general surgery: enhancing precision, efficiency, and outcomes
Authors: S. Fuentes Sergio M. , Chávez Luis A F. , López Eduardo M. M. , Cardona Christian D. C. , Goti Laís L. M.
Published: January 2025

The integration of artificial intelligence (AI) into general surgery has brought significant advancements in surgical precision, postoperative complication prediction, and intraoperative assistance. Despite its potential, AI faces challenges regarding its broad implementation in clinical practice. This systematic review aims to assess the impact of AI on clinical outcomes in general surgery, including diagnostic accuracy, complication prediction, and surgical error reduction. A systematic review was conducted using PubMed, Scopus, and Web of Science databases, focusing on studies published between 2020 and 2024. Inclusion criteria required studies that evaluated AI’s role in general surgery with a sample size of at least 50 patients. Studies reporting both qualitative and quantitative outcomes, including complication prediction and intraoperative assistance, were included. Ten studies were selected, involving a total of 12,580 patients undergoing various surgical procedures such as hepatectomies, colectomies, and cholecystectomies. AI significantly improved complication prediction accuracy (25% improvement over traditional methods) and reduced intraoperative errors by 18%. Additionally, AI-assisted surgeries showed an average reduction of 30 minutes in surgical time, from 150 to 120 minutes in complex cases. AI has proven to be a valuable tool in general surgery, particularly in complex procedures where precision and complication prediction are critical. However, further studies are needed to validate AI models across diverse populations and healthcare settings to ensure widespread adoption.
Associations between smartphone use and mental disorders in college students: a systematic review
Authors: Santos Renata Maria Silva , Oliveira Gabriela Bahia de , Fernandes Fernanda Martins , Ventura Samara de Alcântara , Romano-Silva Marco Aurélio , Miranda Debora Marques de
Published: January 2025

Smartphones are now ubiquitous in the daily lives of undergraduate students, but their excessive use may be related to psychological problems and to the development of mental disorders. To verify the influence of smartphone use on the development of mental disorders in university students, a systematic review of the literature was conducted, according to preferred reporting items for systematic reviews and meta-analysis (PRISMA) and registered in PROSPERO under number CRD42023401060. The search was carried out in June 2024 with the descriptors: “smartphone”, “university students”, “college students” and “mental disorders”, in the PubMed, PsycInfo and Scopus databases. Of the 48 studies included, most found associations between excessive use of smartphones and the presence of mental disorders in university students. Only two articles observed improvement in anxiety, depression and stress associated with smartphone use and one study found no associations. Depression, anxiety, and stress were the main mental disorders found among university students. The excessive use of smartphones is associated with the presence of psychological problems in university students. Constant smartphone availability and online studies favours the development of psychopathologies in university students. The findings in this review strengthen the evidence of the need to develop strategies to live in a healthy way with the digital world.
The role of cognitive and personality factors in youth deliberate self-harm: a systematic review
Authors: Kpeno Audifax , Sahoo Surjeet , Sahu Amiya Krushna , Sahu Pratap Kumar , Bagson Ernest
Published: January 2025

This systematic review aims to investigate the relationship between cognitive factors, emotional tendencies, and personality traits contributing to deliberate self-harm (DSH) behaviour among youth. This systematic review followed the preferred reporting items for systematic reviews and meta-analyses guidelines. Literature searches were conducted in March 2024 using Scopus, PubMed, and Google Scholar, focusing on "deliberate self-harm," "youth," "cognitive factors," and "personality profiles." The search was limited to articles in English from medicine, psychology, and social sciences, published in the U. S., Canada, Australia, the U. K., and New Zealand. Articles were selected based on their relevance to youth DSH and related cognitive constructs, excluding those focused on suicidal ideation. A narrative synthesis was performed, and study quality was assessed using the Cochrane risk of bias tool. A total of 21 articles were identified and included in the final review. Emotional regulation emerges as crucial in preventing DSHing behaviours, with early detection facilitated by screening for impulsivity, sensation-seeking, and emotional dysregulation. Prevention strategies targeting specific cognitive patterns and personality traits associated with self-harm are informed by insights from this review, drawing from diverse studies. Limited yet promising evidence underscores the need for further research to elucidate these relationships. Additionally, significant correlations between specific online behaviors and DSH among youth are noted. Understanding these cognitive constructs and personality traits can offer timely support and guidance in clinical practice, potentially leading to more effective, personalized interventions for reducing DSH behaviour among youth. Prospero registration no.: crd42024525239.
Gastrointestinal function and quality of life in postoperative patients of pancreatoduodenectomy
Authors: Masabanda Celorio Veronica , Chavez Balanza Luis Arturo , Martínez Ordaz José Luis , Rodríguez Negrete Elda Victoria , Sanchez Reyes Karina
Published: January 2025

Pancreaticoduodenectomy (PD) is a complex, high-risk procedure with insufficient data on long-term quality of life and gastrointestinal function. Therefore, it is necessary to determine the level of quality of life and functional outcomes in these patients. In the following study, we present a case series analysis, establishing a direct relationship between post-surgical evolution and its impact on quality of life and gastrointestinal function, using two questionnaires: Short Form 36 and Gastrointestinal Symptom Rating Scale. Out of 15 patients the prevalence of pancreaticoduodenectomy in women was 69%, with a mean age of 53 years. The average follow-up period was 3.47 years. When applying the Short Form 36, they rated their general health at 68.67 points, emotional well-being at 78 points, and social well-being at 73 points. Regarding the Gastrointestinal Symptom Rating Scale, 100% reported pain and indigestion, some experienced gastroesophageal reflux, diarrhea, steatorrhea, and constipation; none of these symptoms limited daily life. Patients undergoing pancreaticoduodenectomy experience changes in their quality of life; likewise, gastrointestinal function alterations are common. Those who survive the underlying pathology and PD have quality of life and gastrointestinal function close to normal values, with improvements possible through symptom treatment, psychological support, social assistance, and physical rehabilitation.
Obstructive jaundice as the initial manifestation of hepatocellular carcinoma in a patient with previously unknown chronic hepatitis B infection: a case report and literature review
Authors: Blanco Joaquin , Gonzalez Luis D. , Cortes Abigail , Jimenez Nidia , Pavia Mario R. , Gutierrez María X.
Published: January 2025

Hepatocellular carcinoma (HCC) is the most common liver neoplasm, accounting for 90% of cases, with hepatitis B and C infections being the main risk factors for its development. Diagnosis is primarily based on imaging studies, serology, and histology. Clinically, it presents with right upper quadrant pain and B symptoms, with jaundice occurring in 19-40% of cases. However, the onset of obstructive jaundice as the initial symptom occurs in approximately 1-12% of cases. We present the case of a 65-year-old male with a recent diagnosis of diabetes mellitus, who presented with progressive jaundice, documenting suggestive imaging findings of hepatocellular carcinoma with portal involvement and a positive viral panel for hepatitis B. Pathology report confirmed a differentiated hepatocellular carcinoma.
Presentation of a cutaneous fistula due to mesh migration in a postoperative incisional hernia patient
Authors: Hernández Samuel , Villarreal Rodrigo , González Yazmin G.
Published: January 2025

Incisional hernias are a frequent complication after abdominal surgery, ranging from 5-20% and up to 30% in patients with risk factors. Currently, hernia repair with mesh placement is recommended because it helps tension-free closure; however, there are complications such as surgical site infection, seroma, recurrence, fistula and mesh migration. We present the case of a 42-year-old female patient with mesh migration into the abdominal cavity secondary to incisional hernia repair. After reintervention with mesh remove, the patient had a favorable evolution, without complications and was discharged 48 hours after surgery. Currently the gold standard for incisional hernia repair is tension-free with mesh placement, however, this is not safe since there are several complications ranging from surgical site infection to mesh migration; the mesh migration represents a low percentage and its treatment is always surgical, but we must individualize it with each patient. In this case, we present an infrequent complication of open repair with mesh placement of an incisional hernia; however, it should be considered in the postoperative follow-up.
Hemobilia, an uncommon case in a patient with severe acute cholangitis: a case report
Authors: Martinez-Garcia Erik , Roman-Chávez Pedro D. , Galván-Ortiz Marco A. , Figueroa-Zariñana Víctor H. , Madrid-Ruiz José F.
Published: January 2025

Hemobilia is an uncommon cause of upper gastrointestinal bleeding and it is usually associated with hepatobiliary trauma. We present a 71-year-old female patient with type 2 diabetes mellitus and hypertension, who was admitted to the emergency department due to clinical features of a severe acute cholangitis and hemodynamic instability. She required an external drainage through a T-tube in the common bile duct and admission to the intensive care unit in order to improve clinical conditions for a definitive treatment. Afterwards we performed an open cholecystectomy with a satisfactory postsurgical outcome and decided to discharge her. However, she was readmitted due to melena and bleeding through the T-tube, which developed a hypovolemic shock treated with crystalloid fluids and blood transfusion.
It is still in discussion what is the best treatment option. Since the objective is to preserve the integrity of the bile duct, only 5% of the cases will require a major intervention. It is important to individualize every case.
Cerebral venous sinus thrombosis secondary to acute viral meningitis from cytomegalovirus and Epstein-Barr virus in immunocompetent patients: a case report
Authors: Amon-Tanoh Muriel , Magala Gloire Chubaka , Offoumou Fiacre Delors , Kadjo Cédric Valery , Aka Arlette Désirée , Kouassi Roseline Mohou Felandine , Tanoh Abel Christian
Published: January 2025

Cerebral venous sinus thrombosis (CVST) represents about 0.5% to 3% of all stroke cases, with a higher prevalence among younger populations. The estimated incidence is around 3 to 4 cases per million in adults and 7 cases per million in children. In tropical areas, there is often a notable association between infectious diseases and strokes. In sub-Saharan Africa, infections are identified as significant risk factors for cerebral venous thrombosis. Human cytomegalovirus (CMV) and Epstein-Barr virus (EBV), both ubiquitous members of the herpesvirus family, are typically asymptomatic; however, they can, in certain instances, contribute to the development of thromboembolic diseases (TED), particularly in immunocompromised individuals. The incidence of CVST linked to CMV or EBV in immunocompetent individuals without other risk factors is uncommon. This study presents two cases: the first involves a 15-year-old immunocompetent adolescent who experienced a rapid decline in alertness, while the second case pertains to a 43-year-old man who presented with sudden-onset headaches. Magnetic resonance venography (MRV) revealed extensive CVST on the left side in the first case and a sub occlusion of the left transverse sinus in the second. Analysis of cerebrospinal fluid isolated EBV and CMV through PCR, with positive serological results. The clinical outcome was favorable due to anticoagulant treatment combined with symptomatic management of the infections. The risk of CVST should not be overlooked in patients with symptoms related to CMV and EBV infection regardless of immune status and MRV should be considered to rule out this possibility.
Hemoglobin D-Punjab heterozygous encountered in Assam: a case report
Authors: Debnath Tanushree , Pathak Mauchumi S. , Borah Monalisha S. , Phimu Zhoyio L. , Gogoi Ananya
Published: January 2025

Hemoglobin (Hb) D-Punjab is a haemoglobin variant with a point mutation in beta globin gene. A case of Hb D was encountered during screening of Hb variants among undergraduate students. With a prevalence rate of 2% in India, Hb D is generally rare in the Northeast region of India. Among the 200 screened cases, one Hb D heterozygous was detected by analysing the blood sample of the subject with an automated haematology analyser for complete blood count (CBC) and by using high performance liquid chromatography (HPLC) based Hb typing method. The haematological parameters were done in cell counter with Hg % 15.1 g/dl, mean corpuscular volume (MCV) 95 fl and mean corpuscular hemoglobin (MCH) 32.2 pg. The platelet value was high and high mean corpuscular hemoglobin concentration (MCHC) was obtained and the HPLC based haemoglobin typing was done with A2-2.9, A0-53.3, F- <0.8 area percentage and unknown window with 38.2 area percentage (retention time 3.86). Hb D Punjab heterozygous case has been reported in this report as prevalence of Hb D Punjab is very rare in the state of Assam.
Neuroendocrine tumour of a larynx in 70-year-old man: a rare entity and a diagnostic challenge
Authors: Shabbir Nida , Singh Ajay K. , Chandra Manish , Qayoom Sumaira
Published: January 2025

Neuroendocrine tumours of the larynx are rare yet neuroendocrine tumors is the second most common larynx tumour. According to the World Health Organization (WHO) 2022 classification, neuroendocrine tumours (NET) can be classified into well-differentiated, moderately differentiated and poorly differentiated. Well-differentiated NETs (typical carcinoids) of the larynx are rare and largely published as case reports. We present a case of a 70-year-old male with a history of hoarseness of voice for 1 year. Grossly, the tumour was globular and encapsulated. Based on histopathological features and immunohistochemistry results, the final diagnosis of a well-differentiated Neuroendocrine tumour was rendered. For carcinoid tumours of the larynx, conservative surgical resection is the preferred treatment without elective neck dissection. This tumour has a favourable prognosis, rare recurrences, and minimal metastasis.
A case report on sarcoidosis: the great-mimicker
Authors: Majumder Megha , Azmi Mohammad Orooj , Agarwal Harshita , Paul Tirthankar , Bhar Kausik , Barai Manodeep
Published: January 2025

Sarcoidosis is a rare multi-systemic disease of idiopathic etiology with a low incidence and the hallmark histologic feature of non-caseating granulomas. Sarcoidosis can involve any organ system. Thus, the manifestations at presentation are highly variable. Our case features a 55-year-old female who presented with complaints of abdominal pain, anorexia, weight loss, and a history of infrequent dry cough with lymphoma, tuberculosis, and lung carcinoma, the initial differentials in mind. In due course, investigations revealed bilateral renal calculi and hypercalcemia, which eventually led to the diagnosis of sarcoidosis. Hypercalcemia and renal dysfunction in sarcoidosis are relatively rare, affecting less than 10% of patients at presentation. In its acute phase, the consequences of hypercalcemia are reversible, and its prompt treatment subsequently reduces the risk of irreversible renal dysfunction, highlighting the importance of strong suspicion for a disease like sarcoid - the Great Mimicker.
Juvenile chronic myeloid leukemia: a case report
Authors: Pandey Praveen Kumar , Singh Sujeet , Srivastava Amartya Prakash , Srivastava Swati , Singh Nitika , Singh Shivendra Pratap
Published: January 2025

Chronic myeloid leukemia (CML) accounts for 2-3% of leukemias in children under 15 and 9% in adolescents aged 15-19. The diagnosis of CML in children, adolescents, and young adults has several differences compared to that in adults. Juvenile myelomonocytic leukemia (JMML)/ juvenile CML is a rare, malignant myelodysplastic/ myeloproliferative neoplasm (MPN) overlap haemopoetic disorder that presents in infants and toddlers and it must be differentiated from other disorders that can show similar presentation in this age group. JMML is very uncommon and the diagnosis is often difficult to establish. The disease has a rapid course and has a median survival of less than 10 months when untreated or undertreated. In this case report we present a case of a 7-year-old male patient with gingival enlargement and swelling along with mobility of mandibular anterior teeth with various associated systemic factors in which various hematological, biochemical, and radiographic investigations were carried out to differentiate CML from other systemic conditions.