bluuebunny/crossref_metadata_2025 huggingface dataset:
Ultrafast charge ordering by self-amplified exciton–phonon dynamics in TiSe2
Authors: Lian Chao , Zhang Sheng-Jie , Hu Shi-Qi , Guan Meng-Xue , Meng Sheng
Published: January 2020

The origin of charge density waves (CDWs) in TiSe$${}_{2}$$

2

has long been debated, mainly due to the difficulties in identifying the timescales of the excitonic pairing and electron–phonon coupling (EPC). Without a time-resolved and microscopic mechanism, one has to assume simultaneous appearance of CDW and periodic lattice distortions (PLD). Here, we accomplish a complete separation of ultrafast exciton and PLD dynamics and unravel their interplay in our real-time time-dependent density functional theory simulations. We find that laser pulses knock off the exciton order and induce a homogeneous bonding–antibonding transition in the initial 20 fs, then the weakened electronic order triggers ionic movements antiparallel to the original PLD. The EPC comes into play after the initial 20 fs, and the two processes mutually amplify each other leading to a complete inversion of CDW ordering. The self-amplified dynamics reproduces the evolution of band structures in agreement with photoemission experiments. Hence we resolve the key processes in the initial dynamics of CDWs that help elucidate the underlying mechanism.
Realization of Lieb lattice in covalent-organic frameworks with tunable topology and magnetism
Authors: Cui Bin , Zheng Xingwen , Wang Jianfeng , Liu Desheng , Xie Shijie , Huang Bing
Published: January 2020

Lieb lattice has been predicted to host various exotic electronic properties due to its unusual Dirac-flat band structure. However, the realization of a Lieb lattice in a real material is still unachievable. Based on tight-binding modeling, we find that the lattice distortion can significantly determine the electronic and topological properties of a Lieb lattice. Importantly, based on first-principles calculations, we predict that the two existing covalent organic frameworks (COFs), i.e., sp2C-COF and sp2N-COF, are actually the first two material realizations of organic-ligand-based Lieb lattice. Interestingly, the sp2C-COF can experience the phase transitions from a paramagnetic state to a ferromagnetic one and then to a Néel antiferromagnetic one, as the carrier doping concentration increases. Our findings not only confirm the first material realization of Lieb lattice in COFs, but also offer a possible way to achieve tunable topology and magnetism in organic lattices.
An early phase of instructive plasticity before the typical onset of sensory experience
Authors: Roy Arani , Wang Shen , Meschede-Krasa Benyamin , Breffle Jordan , Van Hooser Stephen D.
Published: January 2020

While early experience with moving stimuli is necessary for the development of direction selectivity in visual cortex of carnivores, it is unclear whether experience exerts a permissive or instructive influence. To test if the specific parameters of the experienced stimuli could instructively sculpt the emergent responses, visually naive ferrets were exposed to several hours of experience with unusual spatiotemporal patterns. In the most immature ferrets, cortical neurons developed selectivity to these patterns, indicating an instructive influence. In animals that were 1–10 days more mature, exposure to the same patterns led to a developmentally-typical increase in direction selectivity. We conclude that visual development progresses via an early phase of instructive plasticity, when the specific patterns of neural activity shape the specific parameters of the emerging response properties, followed by a late phase of permissive maturation, when sensory-driven activity merely serves to enhance the response properties already seeded in cortical circuits.
MAP3Kinase-dependent SnRK2-kinase activation is required for abscisic acid signal transduction and rapid osmotic stress response
Authors: Takahashi Yohei , Zhang Jingbo , Hsu Po-Kai , Ceciliato Paulo H. O. , Zhang Li , Dubeaux Guillaume , Munemasa Shintaro , Ge Chennan , Zhao Yunde , Hauser Felix , Schroeder Julian I.
Published: January 2020

Abiotic stresses, including drought and salinity, trigger a complex osmotic-stress and abscisic acid (ABA) signal transduction network. The core ABA signalling components are snf1-related protein kinase2s (SnRK2s), which are activated by ABA-triggered inhibition of type-2C protein-phosphatases (PP2Cs). SnRK2 kinases are also activated by a rapid, largely unknown, ABA-independent osmotic-stress signalling pathway. Here, through a combination of a redundancy-circumventing genetic screen and biochemical analyses, we have identified functionally-redundant MAPKK-kinases (M3Ks) that are necessary for activation of SnRK2 kinases. These M3Ks phosphorylate a specific SnRK2/OST1 site, which is indispensable for ABA-induced reactivation of PP2C-dephosphorylated SnRK2 kinases. ABA-triggered SnRK2 activation, transcription factor phosphorylation and SLAC1 activation require these M3Ks in vitro and in plants. M3K triple knock-out plants show reduced ABA sensitivity and strongly impaired rapid osmotic-stress-induced SnRK2 activation. These findings demonstrate that this M3K clade is required for ABA- and osmotic-stress-activation of SnRK2 kinases, enabling robust ABA and osmotic stress signal transduction.
A prospective three-year follow-up study on the clinical significance of anti-neuronal antibodies in acute psychiatric disorders
Authors: Schou M. B. , Sæther S. G. , Drange O. K. , Brenner E. , Crespi J. , Eikenes L. , Mykland M. S. , Pintzka C. , Håberg A. K. , Sand T. , Vaaler A. , Kondziella D.
Published: January 2020

The clinical significance of anti-neuronal antibodies for psychiatric disorders is controversial. We investigated if a positive anti-neuronal antibody status at admission to acute psychiatric inpatient care was associated with a more severe neuropsychiatric phenotype and more frequent abnormalities during clinical work-up three years later. Patients admitted to acute psychiatric inpatient care who tested positive for N-methyl-D-aspartate receptor (NMDAR), contactin-associated protein 2 (CASPR2) and/or glutamic acid decarboxylase 65 (GAD65) antibodies (n = 24) were age – and sex matched with antibody-negative patients (1:2) from the same cohort (n = 48). All patients were invited to follow-up including psychometric testing (e.g. Symptom Checklist-90-Revised), serum and cerebrospinal fluid (CSF) sampling, EEG and 3 T brain MRI. Twelve antibody-positive (ab+) and 26 antibody-negative (ab−) patients consented to follow-up. Ab+ patients had more severe symptoms of depression (p = 0.03), psychoticism (p = 0.04) and agitation (p = 0.001) compared to ab− patients. There were no differences in CSF analysis (n = 6 ab+/12 ab−), EEG (n = 7 ab+/19 ab−) or brain MRI (n = 7 ab+/17 ab−) between the groups. In conclusion, anti-neuronal ab+ status during index admission was associated with more severe symptoms of depression, psychoticism and agitation at three-year follow-up. This supports the hypothesis that anti-neuronal antibodies may be of clinical significance in a subgroup of psychiatric patients.
Characterization of the furin cleavage motif for HIV-1 trimeric envelope glycoprotein by intact LC-MS analysis
Authors: Schneck Nicole A. , Ivleva Vera B. , Cai Cindy X. , Cooper Jonathan W. , Lei Q. Paula
Published: January 2020

We demonstrate a rapid deglycosylation strategy for recombinant HIV-1 envelope glycoprotein, enabling intact LC-MS mass measurement and furin cleavage monitoring.
A fluorescent three-sensor array for heavy metals in environmental water sources
Authors: Bowyer Amy A. , Shen Clara , New Elizabeth J.
Published: January 2020

A fluorescent sensing array based on analogues of Calcein Blue is able to classify toxic heavy metals in water.
Fabrication of strong hydrogen-bonding induced coacervate adhesive hydrogels with antibacterial and hemostatic activities
Authors: Zhang Dongfei , Xu Ziyang , Li Haofei , Fan Chuanchuan , Cui Chunyan , Wu Tengling , Xiao Meng , Yang Yang , Yang Jianhai , Liu Wenguang
Published: January 2020

A supramolecular polymer adhesive hydrogel prepared by a simple two-component mixing method exhibits strong adhesion to different substrates, and antibacterial and hemostatic activities.
Cyclization of a G4-specific peptide enhances its stability and G-quadruplex binding affinity
Authors: Ngo Khac Huy , Yang Renliang , Das Poulomi , Nguyen Giang K. T. , Lim Kah Wai , Tam James P. , Wu Bin , Phan Anh Tuân
Published: January 2020

Head-to-tail cyclization of a G-quadruplex-specific peptide was shown to enhance its stability and G-quadruplex binding affinity.
Small graphite nanoflakes as an advanced cathode material for aluminum ion batteries
Authors: Hu Haoyu , Cai Tonghui , Bai Peng , Xu Jing , Ge Shihui , Hu Han , Wu Mingbo , Xue Qingzhong , Yan Zifeng , Gao Xiuli , Xing Wei
Published: January 2020

This work reports the preparation of small graphite nanoflakes (SGN) by a new strategy of pulverization as a cathode for aluminum ion batteries (AIBs).
Plasmon-activated nanozymes with enhanced catalytic activity by near-infrared light irradiation
Authors: Liu Xu , Wan Yilin , Jiang Tao , Zhang Yifang , Huang Peng , Tang Longhua
Published: January 2020

The platinum-decorated gold nanorods exhibited notably enhanced enzyme-like catalytic activity under the near-infrared light irradiation and showed the potential in cancer treatment by evaluation of the catalytic activity and cytotoxicity in cells.
Elastase-triggered H2S delivery from polymer hydrogels
Authors: Zhou Mingjun , Qian Yun , Zhu Yumeng , Matson John
Published: January 2020

A polymer hydrogel was prepared that underwent a gel-to-sol transition in response to the enzyme elastase, triggering release of H2S from incorporated S-aroylthiooximes.
Bright carbon nanodots for miRNA diagnostics coupled with concatenated hybridization chain reaction
Authors: Liu Guangxing , Chai Hua , Tang Yuguo , Miao Peng
Published: January 2020

Bright carbon nanodot–DNA nanoconjugates are prepared for target miRNA induced concatenated hybridization chain reaction.
5,6-Fused bicyclic tetrazolo-pyridazine energetic materials
Authors: Chen Sitong , Liu Yuji , Feng Yongan , Yang Xianjin , Zhang Qinghua
Published: January 2020

Two 5,6-fused tetrazolo-pyridazine compounds were synthesized and characterized, which exhibited high thermal stability, excellent energetic properties and low mechanical sensitivity.
Formation of breathing pyrochlore lattices: structural, thermodynamic and crystal chemical aspects
Authors: Talanov Mikhail V. , Talanov Valeriy M.
Published: January 2020

The structural diversity of breathing pyrochlore lattices was investigated on the example of ordered pyrochlores in terms of group-theoretical analysis, Landau thermodynamics and crystal chemistry.
Unexpected crystalline memory effect in poly(l-lactide)-based block copolymers
Authors: Tong Zaizai , Su Yawei , Wang Rui-Yang , Xu Jun-Ting
Published: January 2020

The unexpected crystalline memory effect in poly(l-lactide)-based block copolymers.
Push–pull thiophene chromophores for electro-optic applications: from 1D linear to β-branched structures
Authors: Rothe Christian , Neusser David , Hoppe Niklas , Dirnberger Klaus , Vogel Wolfgang , Gámez-Valenzuela Sergio , López Navarrete Juan T. , Villacampa Belén , Berroth Manfred , Ruiz Delgado M. Carmen , Ludwigs Sabine
Published: January 2020

This study demonstrates that β-branched thiophenes exhibit improved NLO properties and thermal stability for electro-optic applications compared to 1D linear systems.
Characterization of β-turns by electronic circular dichroism spectroscopy: a coupled molecular dynamics and time-dependent density functional theory computational study
Authors: Migliore Mattia , Bonvicini Andrea , Tognetti Vincent , Guilhaudis Laure , Baaden Marc , Oulyadi Hassan , Joubert Laurent , Ségalas-Milazzo Isabelle
Published: January 2020

TDDFT coupled with molecular dynamics simulations are used for β-turn characterization by ECD spectroscopy.
Electron transfer in nonpolar media
Authors: Matyushov Dmitry V.
Published: January 2020

Electron transfer in nonpolar media violates the temperature scaling predicted by the fluctuation–dissipation theorem.
Heterogeneity in the microstructure and dynamics of tetraalkylammonium hydroxide ionic liquids: insight from classical molecular dynamics simulations and Voronoi tessellation analysis
Authors: Reddy Th. Dhileep N. , Mallik Bhabani S.
Published: January 2020

Microscopic structural and dynamic heterogeneities were investigated for three ionic liquids (ILs), tetraethylammonium hydroxide, tetrapropylammonium hydroxide, and tetrabutylammonium hydroxide employing classical molecular dynamics (MD) simulations.
Effects of high-shear mixing and the graphene oxide weight fraction on the electrochemical properties of the GO/Ni(OH)2 electrode
Authors: Yuan Yinan , Liu Zhaoyuan , Wei Bing , Yang Ziyue , Wang Lidong , Fei Weidong
Published: January 2020

High-shear mixing can efficiently enhance the homogeneity and the electrochemical performances of the GO/Ni(OH)2 composite.
A reversible chromogenic covalent organic polymer for gas sensing applications
Authors: Subodh Subodh , Prakash Kunal , Masram Dhanraj T.
Published: January 2020

A triazine-based covalent organic polymer (COP) was designed, synthesized and utilized as a quick, portable and reversible chromogenic sensor for noxious HCl gas.
A self-calibrating and multiplexed electrochemical lab-on-a-chip for cell culture analysis and high-resolution imaging
Authors: Giménez-Gómez Pablo , Rodríguez-Rodríguez Rosalía , Ríos Juan Manuel , Pérez-Montero Marta , González Estrella , Gutiérrez-Capitán Manuel , Plaza Jose Antonio , Muñoz-Berbel Xavier , Jiménez-Jorquera Cecilia
Published: January 2020

Highly compartmentalized lab-on-a-chip for multi-parametric cell culture analysis and drug screening.
Simultaneously enabling dynamic transparency control and electrical energy storage via electrochromism
Authors: Li Haizeng , Elezzabi Abdulhakem Y.
Published: January 2020

The newly established Zn anode-based aqueous electrochromic device enables dynamic transparency control and electrical energy storage in a single platform.
A simple D–π–A system of phenanthroimidazole-π-fluorenone for highly efficient non-doped bipolar AIE luminogens: synthesis, and molecular optical, thermal and electrochemical properties
Authors: Kathirvelan Devarajan , Mayakrishnan Sivakalai , Uma Maheswari Narayanan , Biswas Chinmoy , Raavi Sai Santosh Kumar , Panda Tarun K.
Published: January 2020

We report the synthesis of phenanthroimidazole based dyes incorporating fluorenone using Suzuki coupling and their aggregation induced emission characterisation.
The catalytic effects of nano-Fe2O3 and rGO–Fe2O3 on the thermal decomposition properties of CL-20/HMX cocrystals
Authors: Wu Zongkai , Pei Jiangfeng , Song Xiuduo , Liu Ning , Li Jianguo , Zhang Ming , Zhang Jun , Zhang Dongxiang , Zhao Fengqi
Published: January 2020

Adding nano-Fe2O3 to a CL-20/HMX cocrystal affects its thermal decomposition peak temperature and products.
Tunneling-based rectification and photoresponsivity in black phosphorus/hexagonal boron nitride/rhenium diselenide van der Waals heterojunction diode
Authors: Afzal Amir Muhammad , Javed Yasir , Akhtar Shad Naveed , Iqbal Muhammad Zahir , Dastgeer Ghulam , Munir Sajid M. , Mumtaz Sohail
Published: January 2020

The BP/h-BN/ReSe2 heterostructure demonstrates the highest tunneling-based rectification ratio and responsivity. The tunneling device operates in switching operation at up to GHz frequency.
A mini-review: emerging all-solid-state energy storage electrode materials for flexible devices
Authors: Yang Yang
Published: January 2020

New technologies for future electronics such as personal healthcare devices and foldable smartphones require emerging developments in flexible energy storage devices as power sources.
An Fe–V@NiO heterostructure electrocatalyst towards the oxygen evolution reaction
Authors: Zhu Yu-Xun , Jiang Mei-Yan , Liu Min , Wu Lian-Kui , Hou Guang-Ya , Tang Yi-Ping
Published: January 2020

The development of a nonprecious and Earth-abundant electrocatalyst with high electrocatalytic activity for the oxygen evolution reaction (OER) is an emerging hot issue and remains a grand challenge.
Influence of a substrate on ultrafast interfacial charge transfer and dynamical interlayer excitons in monolayer WSe2/graphene heterostructures
Authors: Xing Xiao , Zhao Litao , Zhang Wenjie , Wang Zhuo , Su Huimin , Chen Huaying , Ma Guohong , Dai Junfeng , Zhang Wenjing
Published: January 2020

Efficient interfacial light–electric interconversion in van der Waals heterostructures is critical for their optoelectronic applications.
Mars–van-Krevelen mechanism-based blackening of nano-sized white semiconducting oxides for synergetic solar photo-thermocatalytic degradation of dye pollutants
Authors: Bao Haoming , Zhu Shuyi , Zhou Le , Fu Hao , Zhang Hongwen , Cai Weiping
Published: January 2020

A facile Mars–van-Krevelen mechanism-based blackening (or enhancing the optical absorption in visible region) method of nano-sized white semiconducting oxides (N-WSOs) is presented for enhanced solar utilization via heating the N-WSOs with alcohols.
Biocompatibility assessment of sub-5 nm silica-coated superparamagnetic iron oxide nanoparticles in human stem cells and in mice for potential application in nanomedicine
Authors: Ledda Mario , Fioretti Daniela , Lolli Maria Grazia , Papi Massimiliano , Di Gioia Cira , Carletti Raffaella , Ciasca Gabriele , Foglia Sabrina , Palmieri Valentina , Marchese Rodolfo , Grimaldi Settimio , Rinaldi Monica , Lisi Antonella
Published: January 2020

Ultrafine sub-5 SIO-Fl superparamagnetic nanoparticles evaluated in human stem cells and in mice as a novel promising biomaterial for application in nanomedicine.
Alkylarylation of N-allylbenzamides and N-allylanilines with simple ethers for the direct construction of ether substituted dihydroisoquinolinones and indolines
Authors: Li Yiting , Sun Song , Cheng Jiang , Yu Jin-Tao
Published: January 2020

A radical-initiated alkylarylation of unactivated alkenes with ethers to form ether-substituted dihydroisoquinolinones and indolines was achieved.
Cleavable coumarin-based oxime esters with terminal heterocyclic moieties: photobleachable initiators for deep photocuring under visible LED light irradiation
Authors: Qiu Wanwan , Li Mengqi , Yang Yinan , Li Zhiquan , Dietliker Kurt
Published: January 2020

Oxime ester photoinitiators with terminal heterocyclic moieties can efficiently initiate acrylate and thiol–ene photopolymerization under 450 nm LED light irradiation to prepare materials of thickness up to 10 mm.
The synthesis of calcium arsenate@iron arsenate coating materials and their application for arsenic-containing wastewater treatment
Authors: Wang Yang , Rong Zhihao , Tang Xincun , Cao Shan
Published: January 2020

Calcium arsenic salts converted to coating materials by ferric salts. The coating materials can be used for arsenic immobilization.
Discovery and structure characteristics of the intermediate-state conformation of poly(9,9-dioctylfluorene) (PFO) in the dynamic process of conformation transformation and its effects on carrier mobility
Authors: Liu Bin , Bai Zeming , Li Tao , Liu Yang , Li Xiaona , Zhang Hao , Lu Dan
Published: January 2020

Good solution processability is a prerequisite for fabricating polymer optoelectronic devices.
A novel drug–drug coamorphous system without molecular interactions: improve the physicochemical properties of tadalafil and repaglinide
Authors: Su Meiling , Xia Yanming , Shen Yajing , Heng Weili , Wei Yuanfeng , Zhang Linghe , Gao Yuan , Zhang Jianjun , Qian Shuai
Published: January 2020

The coamorphous tadalafil–repaglinide (molar ratio, 1 : 1) prepared by solvent-evaporation method significantly improve the physicochemical properties of tadalafil and repaglinide.
Development of multiple reaction monitoring assay for quantification of carnosine in human plasma
Authors: Pandya Vaibhav Kumar , Sonwane Babasaheb , Rathore Rajeshwari , Unnikrishnan A. G. , Kumaran Sangaralingam , Kulkarni Mahesh J.
Published: January 2020

Human plasma carnosine quantification by developing a sensitive multiple reaction monitoring method.
Electronic characterization of redox (non)-innocent Fe2S2reference systems: a multi K-edge X-ray spectroscopic study
Authors: Oudsen J. P. H. , Venderbosch B. , Korstanje T. J. , Tromp M.
Published: January 2020

Di-iron dithiolate hydrogenase model complexes are promising systems for electrocatalytic production of dihydrogen and have therefore been spectroscopically and theoretically investigated in this study.
Separation of neodymium and dysprosium by solvent extraction using ionic liquids combined with neutral extractants: batch and mixer-settler experiments
Authors: Riaño Sofía , Sobekova Foltova Simona , Binnemans Koen
Published: January 2020

The combination of ionic liquids with Cyanex 923 improves the separation of Nd(iii) and Dy(iii).
Asymmetric molecular modification of viologens for highly stable electrochromic devices
Authors: Kim Mark , Kim Yong Min , Moon Hong Chul
Published: January 2020

Asymmetric viologens are proposed for highly stable electrochromic devices.
Rapid, quantitative and ultra-sensitive detection of cancer biomarker by a SERRS-based lateral flow immunoassay using bovine serum albumin coated Au nanorods
Authors: Lu Luchun , Yu Jiangliu , Liu Xiaoxian , Yang Xingsheng , Zhou Zihui , Jin Qing , Xiao Rui , Wang Chongwen
Published: January 2020

A rapid, sensitive, and stable SERRS-LFIA strip was developed for AFP detection using BSA-coated AuNRs as SERRS nanotags.
Synthesis of Ag and AgCl co-doped ZIF-8 hybrid photocatalysts with enhanced photocatalytic activity through a synergistic effect
Authors: Jing Yanqiu , Lei Qiang , Xia Chun , Guan Yu , Yang Yide , He Jixian , Yang Yang , Zhang Yonghui , Yan Min
Published: January 2020

Recently, Ag/AgCl composites with different structures have been widely studied and used as photocatalysts to degrade dye pollutants, due to their high separation efficiency of electron–hole pairs under visible light irradiation.
Rotaxane PtII-complexes: mechanical bonding for chemically robust luminophores and stimuli responsive behaviour
Authors: Zhang Zhihui , Tizzard Graham J. , Williams J. A. Gareth , Goldup Stephen M.
Published: January 2020

We report an approach to interlocked PtII luminophores in which the mechanical bond stabilises the coordination environment of the embedded metal ion.
Co-production of pure hydrogen, carbon dioxide and nitrogen in a 10 kW fixed-bed chemical looping system
Authors: Bock Sebastian , Zacharias Robert , Hacker Viktor
Published: January 2020

Fixed-bed chemical looping for the generation of high purity hydrogen with sequestration of pure carbon dioxide and nitrogen.
Direct solar thermochemical conversion of methanol into syngas via nanocatalysts at lower temperatures
Authors: Zeng Jia , Yu Xiaoxiao , Xuan Yimin , Li Qiang , Liu Dong
Published: January 2020

With efficient solar absorption and a suitable methanol supply rate, decomposition is realized with catalyst nanoparticles.
End-to-end machine learning for experimental physics: using simulated data to train a neural network for object detection in video microscopy
Authors: Minor Eric N. , Howard Stian D. , Green Adam A. S. , Glaser Matthew A. , Park Cheol S. , Clark Noel A.
Published: January 2020

We demonstrate a method for training a convolutional neural network with simulated images for usage on real-world experimental data.
The transbilayer distribution of polyunsaturated phospholipids determines their facilitating effect on membrane deformation
Authors: Tiberti Marion L. , Antonny Bruno , Gautier Romain
Published: January 2020

In the cell, membrane deformation and fission (collectively referred to as ‘budding’) is driven by specific protein machineries but is also influenced by lipid composition.
Inherent impurities in 3D-printed electrodes are responsible for catalysis towards water splitting
Authors: Browne Michelle P. , Urbanova Veronika , Plutnar Jan , Novotný Filip , Pumera Martin
Published: January 2020

Researchers should be cautious about the presence of metal impurities in commercial conductive filaments and its crucial effect on O2 based electrocatalysis, which is altered depending on the post 3D-printing treatment.
A flexible, hierarchically porous PANI/MnO2 network with fast channels and an extraordinary chemical process for stable fast-charging lithium–sulfur batteries
Authors: Zhang Yunjing , Liu Xiaolin , Wu Liang , Dong Wenda , Xia Fanjie , Chen Liangdan , Zhou Na , Xia Lixue , Hu Zhi-Yi , Liu Jing , Mohamed Hemdan S. H. , Li Yu , Zhao Yan , Chen Lihua , Su Bao-Lian
Published: January 2020

A three-dimensional hierarchically porous network formed by ultra-thin flexible polyaniline decorated manganese dioxide nanoparticles (PANI–MnO2) demonstrates fast-charging performance for lithium–sulfur batteries.
Crown ether modified membranes for Na+-responsive controllable emulsion separation suitable for hypersaline environments
Authors: Zhai Huajun , Qu Ruixiang , Li Xiangyu , Liu Yanan , Wei Yen , Feng Lin
Published: January 2020

Smart superwetting materials have limited application for oil/water emulsion separation in the ocean due to the hypersaline environment.
Cryoablation-activated enhanced nanodoxorubicin release for the therapy of chemoresistant mammary cancer stem-like cells
Authors: Hou Yi , Sun Xuyang , Yao Siyuan , Rao Wei , He Xiaoming
Published: January 2020

Anticancer nanodoxorubicin with targeting ability, thermal responsive and pH sensitive characteristic is fabricated. Nanodrug could realize controllable and enhanced drug release when cryoablation is applied at the target tumor site.
A ratiometric fluorescent probe for detecting the endogenous biological signaling molecule superoxide anion and bioimaging during tumor treatment
Authors: Wang Yue , Wang Xiaoyan , Zhang Li , Huang Yan , Bi Liyan , Lv Changjun , Chen Lingxin
Published: January 2020

A fluorescent probe for O2˙− detection during tumor treatment revealed that curcumin can sensitize cisplatin for tumor treatment by inducing severe O2˙− burst.
Ti3C2Tx MXene-derived TiO2/C-QDs as oxidase mimics for the efficient diagnosis of glutathione in human serum
Authors: Jin Zhaoyong , Xu Gengfang , Niu Yusheng , Ding Xiaoteng , Han Yaqian , Kong Wenhan , Fang Yanfeng , Niu Haitao , Xu Yuanhong
Published: January 2020

A Ti3C2Tx MXene-derived TiO2/C-QD oxidase mimic was developed and used for the efficient diagnosis of glutathione in human serum.
A carbon nanocoil-based flexible tip for a live cell study of mechanotransduction and electro-physiological characteristics
Authors: Wang Peng , Geng Chunyang , Pan Lujun , Liu Bo
Published: January 2020

An individual CNC tip is used to apply local mechanical and electrical stimulation on a single live cell, and it shows excellent biocompatibility and physical properties for the study of signal transduction non-invasively in live cells.
Dendrimeric calcium-sensitive MRI probes: the first low-field relaxometric study
Authors: Garello Francesca , Gündüz Serhat , Vibhute Sandip , Angelovski Goran , Terreno Enzo
Published: January 2020

In the present work the first investigation ever of calcium sensitive dendrimer relaxation mechanisms at low fields is reported.
Interdependence of shape and magnetic properties in Al-nanoparticles doped with Ni and Pt
Authors: López-Estrada Omar , Orgaz Emilio , Baletto Francesca
Published: January 2020

By means ofab initiomolecular dynamics, we investigate the magnetic behaviour of Al, AlNi and AlPt nanoparticles of 19 atoms. New geometrical shapes are detected and a depression of the total magnetization is associated with geometrical reconstructions where the fivefold symmetry character is lost, independently of the chemical doping.
An excited state managing molecular design platform of blue thermally activated delayed fluorescence emitters by π-linker engineering
Authors: Lee Kyung Hyung , Jeon Soon Ok , Chung Yeon Sook , Numata Masaki , Lee Hasup , Lee Eun Kyung , Kwon Eun Suk , Sim Myungsun , Choi Hyeonho , Lee Jun Yeob
Published: January 2020

A molecular design platform of blue thermally activated delayed fluorescence (TADF) emitters to boost the external quantum efficiency and efficiency roll-off of blue TADF organic light-emitting diodes (OLEDs) was developed.
Aggregation-induced phosphorescent emission-active Ir(iii) complexes with a long lifetime for specific mitochondrial imaging and tracking
Authors: Li Yang , Ma Bo , Long Yugui , Song Ze , Su Jianyuan , Wang Yu , Liu Rui , Song Guangliang , Zhu Hongjun
Published: January 2020

Ir(iii) complexes have been widely used in bio-imaging, photocatalysis and chemical sensing. Five cyclometalated Ir(iii) complexes (Ir1–Ir5) were synthesized and characterized.
DDAB-assisted synthesis of iodine-rich CsPbI3 perovskite nanocrystals with improved stability in multiple environments
Authors: Huang Yihui , Luan Weiling , Liu Mengke , Turyanska Lyudmila
Published: January 2020

Optimized method for synthesis of CsPbI3 NCs using dodecyldimethylammonium bromide as capping molecules can achieve enhanced stability.
MicroRNA-101-3p inhibits fibroblast-like synoviocyte proliferation and inflammation in rheumatoid arthritis by targeting PTGS2
Authors: Wei Qiaofeng , Lv Fang , Zhang Hongju , Wang Xinfang , Geng Qin , Zhang Xiuying , Li Tongying , Wang Shujun , Wang Yajuan , Cui Yanhui
Published: January 2020

Objective: Rheumatoid arthritis (RA) is the most frequently occurring inflammatory arthritis. The present study was performed to characterize the role of microRNA-101-3p (miR-101-3p) and prostaglandin-endoperoxide synthase 2 (PTGS2) in inflammation and biological activities of fibroblast-like synoviocytes (FLSs) in RA.

Methods: Initially, miR-101-3p and PTGS2 expression in RA tissues of RA patients and RA rats was detected by qRT-PCR and Western blot analysis. Rat model of type II collagen-induced arthritis (CIA) was adopted to simulate RA, followed by injection of miR-101-3p mimics or siRNA against PTGS2. Next, the apoptosis in synovial tissue and the levels of tumor necrosis factor (TNF)-α, IL-1β and IL-6 were identified. Subsequently, FLSs in RA (RA-FLSs) were isolated, after which in vitro experiments were conducted to analyze cell proliferation, apoptosis, migration and invasion upon treatment of up-regulated miR-101-3p and silenced PTGS2. Furthermore, the relationship of miR-101-3p and PTGS2 was determined by bioinformatics prediction and luciferase activity assay.

Results: We identified poorly expressed miR-101-3p and highly expressed PTGS2 in synovial tissues of RA patients and RA rats, which showed reduced synoviocyte apoptosis and enhanced inflammation. In response to miR-101-3p mimics and si-PTGS2, the RA-FLSs were observed with attenuated cell proliferation, migration and invasion, corresponding to promoted apoptosis. Down-regulation of PTGS2 could rescue the effect of inhibited miR-101-3p in synovial injury and phenotypic changes of FLS in RA rats. Notably, miR-101-3p was found to negatively regulate PTGS2.

Conclusion: Taken together, miR-101-3p reduces the joint swelling and arthritis index in RA rats by down-regulating PTGS2, as evidenced by inhibited FLS proliferation and inflammation.
Effect of lentivirus-mediated CFTR overexpression on oxidative stress injury and inflammatory response in the lung tissue of COPD mouse model
Authors: Xu Xiaoli , Huang Huimin , Yin Xiangyi , Fang Hongmei , Shen Xiaoyue
Published: January 2020

We aimed to investigate the regulatory mechanism of lentivirus-mediated overexpression of cystic fibrosis transmembrane conductance regulator (CFTR) in oxidative stress injury and inflammatory response in the lung tissue of mouse model of chronic obstructive pulmonary disease (COPD). COPD mouse model induced by cigarette smoke was established and normal mice were used as control. The mice were assigned into a normal group (control), a model group (untreated), an oe-CFTR group (injection of lentivirus overexpressing CFTR), and an oe-NC group (negative control, injection of lentivirus expressing irrelevant sequences). Compared with the oe-NC group, the oe-CFTR group had higher CFTR expression and a better recovery of pulmonary function. CFTR overexpression could inhibit the pulmonary endothelial cell apoptosis, reduce the levels of glutathione (GSH), reactive oxygen species (ROS), and malondialdehyde (MDA) and increase the values of superoxide dismutase (SOD), GSH peroxidase (GSH-Px), and total antioxidant capacity (T-AOC). The overexpression also led to reductions in the white blood cell (WBC) count in alveolus pulmonis, the concentrations of C-reactive protein (CRP), interleukin (IL)-6, and tumor necrosis factor-α, and the protein expressions of NF-κB p65, ERK, JNK, p-EPK, and p-JNK related to MAPK/NF-κB p65 signaling pathway. In conclusion, CFTR overexpression can protect lung tissues from injuries caused by oxidative stress and inflammatory response in COPD mouse model. The mechanism behind this may be related to the suppression of MAPK/NF-κB p65 signaling pathway.
EpiCO (epirubicin, cyclophosphamide and vincristine) as treatment for extrapulmonary high-grade neuroendocrine neoplasms
Authors: Munker Stefan , Vogelhuber Martin , Bornschein Jan , Stroszczynski Christian , Evert Matthias , Schlitt Hans , Herr Wolfgang , Teufel Andreas
Published: January 2020

High-grade neuroendocrine neoplasms (NEN) comprise a rare entity. Due to the lack of randomized controlled trials, therapy recommendations were mainly extrapolated from its pulmonary analogue, small cell lung cancer and mostly validated in small retrospective case series. The multicentric Nordic NEC Study of gastro-entero-pancreatic (GEP) and cancer of unknown primary (CUP) high-grade neuroendocrine neoplasms showed a significant disease control upon treatment with etoposide and platinum-based chemotherapies 1. Such a combination with etoposide and a platinum (CE) compound is currently considered standard first-line treatment for high-grade GEP/CUP NEN. High-grade mixed-neuroendocrine-non-neuroendocrine neoplasms (MiNEN) formerly termed mixed adeno-neuroendocrine carcinomas (MANEC) also have a poor prognosis and are generally treated like other high-grade NEN. The CE protocol has significant activity in high-grade NEN and MiNEN, but the response is short-lived in most cases with response rates around 50–60 %. Second-line treatment alternatives are not established so far. The need for additional treatment options is evident.

Combination chemotherapy with doxorubicin, cyclophosphamide and vincristine (CAV) showed efficacy in small cell lung carcinoma (SCLC) and was considered standard first-line therapy before the era of etoposide and platinum combinations. Due to a better toxicity profile, doxorubicin was replaced by epirubicin, resulting in the combination of epirubicin, cyclophosphamide and vincristine (abbreviated as EpiCO or CEV).

In analogy to SCLC, selected patients with high-grade NEN were treated with the EpiCO regimen in second line (or in one patient first line) at our center. In this report we present the retrospective series of 5 cases with metastatic high-grade GEP/CUP NEN/MiNEN who received chemotherapy according to this protocol.
Persea Americana Seeds Cause Ileal Smooth Muscle Relaxation Via Stimulation of α-1 Adrenoceptors
Authors: Oridupa Olayinka Ayotunde , Oshinloye Adedunke Omobolanle , Obisesan Ayobami Deborah , Olateju Opeyemi Mordiyah , Adenuga Victor Adedotun
Published: January 2020

The effect of methanol extract of P. americana seeds on isolated ileal smooth muscle was studied for isometric response using 10 adult rabbits of both sexes. Reactivity and agonist-antagonist responses of rabbit ileum to the extract were determined in this study. The affinity, effective concentration to give 50% response (EC50) and maximum response were calculated from the concentration response curves (CRC) obtained. The result for the reactivity study showed the seed extract of P. americana caused concentration dependent relaxation of isolated rabbit ileum with threshold responses at concentration of 1×10−9 mg/ml and 120 mg/ml respectively. The extract-antagonist study showed an upward and right shift in CRC in the presence of phenoxybenzamine, a non-selective adrenergic antagonist, with the EC50 increased from 5.01 mg/ml to 12.59 mg/ml and affinity decreased from 0.20 to 0.08. Extract-antagonist study also showed a right and upward shift in the CRC with a greater magnitude in the presence of prazosin, an α1-adrenergic antagonist, with EC50 increased from 0.32 mg/ml to 25.12 mg/ml and a consequential decrease in the affinity from 3.13 to 0.04. In the presence of propranolol, a β-adrenergic antagonist, a downward and left shift in the CRC was observed with the EC50 and PA2 remaining constant at 0.1 mg/ml and 10 respectively. P. americana concentration-dependently reduced or inhibited gastric motility, increasing transit time which is important for food absorption, thus a pro-nutritive and antispasmodic effect. The interaction with α1-adrenoceptors is beneficially in heart failure management. The plant can be developed as a drug candidate for management of hypertension.
Suppressive Effects of Hot-water Extract of Magnolia obovata on Clostridium perfringens Enterotoxin-induced Cytotoxicity in Human Intestinal Caco-2 Cells
Authors: Kawahara Takeshi , Fujii Kotomi , Nakajima Kouki , Fujii Rikuri , Inagaki Shuichiro , Hara Kunio , Yasui Hisako
Published: January 2020

The physiological functions of the leaves of Japanese big-leaf magnolia (Magnolia obovata) against enterotoxins produced by foodborne pathogens remain unclear. In this study, we evaluated the protective effects of M. obovata leaf extract (MLE) against the cytotoxicity of Clostridium perfringens enterotoxin (CPE), which causes the symptoms of C. perfringens type A food poisoning. The protective effects of MLE against CPE-induced cytotoxicity were evaluated in human intestinal epithelial Caco-2 cells. Pre-treatment with MLE significantly suppressed the cytotoxicity induced by CPE in undifferentiated and differentiated human intestinal Caco-2 cells at a pH range of 4.0 – 7.0. This CPE-suppressive effect was due to a hydrophilic sugar-containing compound without phenolic and protein structures but not the hydrophobic biologically active neolignans, honokiol and magnolol. MLE had a protective effect against cytotoxicity caused by type A C. perfringens. Our results provide novel insight regarding the usage of M. obovata in managing food poisoning.
Synthesis and Biological Evaluation of Novel 2-Substituted ­Analogues of (–)-Pentenomycin I
Authors: Zisopoulou Stavroula A. , Bousis Spyridon , Haupenthal Jörg , Herrmann Jennifer , Müller Rolf , Hirsch Anna K. H. , Komiotis Dimitri , Gallos John K. , Stathakis Christos I.
Published: January 2020

A library of novel 2-substituted derivatives of the antibiotic natural product pentenomycin I is presented. The new collection of analogues is divided in two main classes, 2-alkynyl- and 2-aryl- derivatives, which are accessed by the appropriate type of palladium-catalyzed cross-coupling reaction of the 2-iodo-protected pentenomycin I with suitable nucleophiles. The new derivatives were tested for their activity against certain types of bacteria and one of them, compound 8h, was found to exhibit significant inhibitory activity against several Gram-positive bacteria but also displayed cytotoxic activity against eukaryotic cell lines.
Cyclopentene Assembly by Microwave-Assisted Domino Reaction of Donor–Acceptor Cyclopropanes with Ketals
Authors: Nguyen Hung M. , Chand Hemender R. , Golantsov Nikita E. , Trushkov Igor V. , Voskressensky Leonid G.
Published: January 2020

A Lewis acid-mediated domino reaction of acetals derived from aromatic ketones with 2-(het)arylcyclopropane-1,1-diesters has been developed. The reaction provides a convenient approach to cyclopentenes and related polycyclic ring systems.
Synthetic Approaches to Unsymmetrically Substituted 5,7-Dihydroxycoumarins
Authors: Fatykhov Ramil F. , Chupakhin Oleg N. , Inyutina Anna K. , Khalymbadzha Igor A.
Published: January 2020

The chemical equivalence of the hydroxy groups in the 5,7-dihydroxycoumarin core has challenged synthetic chemists to develop short and efficient strategies for the selective modification of one of the hydroxy groups leaving the second intact. Over the past 100 years, chemists have proposed various approaches to distinguishing between these two groups according to their reactivity. While the early syntheses included simple nonselective reactions of both hydroxy groups and the subsequent separation of mixtures of the 5-O- and 7-O-isomers formed, recent sophisticated approaches often include the introduction of protective groups for selective directing reactions or the completely controlled construction of the 5,7-dihydroxycoumarin framework by Horner–Wadsworth–Emmons reaction. This review discusses in detail approaches towards unsymmetrically substituted 5,7-dihydroxycoumarins as well as factors influencing 5-O vs. 7-O regioselectivity of reactions of 5,7-dihydroxycoumarins. This review covers all the literature since 1921 with an emphasis on recent works. This critical review may facilitate the synthesis of new drug candidates as well as the total synthesis of natural products.

1 Introduction

2 O-Modification of 5,7-Dihydroxycoumarins

2.1 Alkylation/Alkenylation

2.2 Acylation

2.3 Sulfonylation

2.4 Silylation

2.5 Acylation Followed by Alkylation

3 Other Approaches

3.1 Synthesis from Substituted Phloroglucinol

3.2 Synthesis from Derivatives of 2-Acylphloroglucinol

4 Conclusion
Catalyst-Free Synthesis of 1,4-Dihydroquinolines and Pyrrolo[1,2-a]quinolines via Intermolecular [4+2]/[3+2] Radical Cyclization of N-Methylanilines with Alkynoates
Authors: Luo Zaigang , Han Xinxin , Liu Chenfu , Liu Qiannan , Li Rui , Liu Peng , Xu Xuemei
Published: January 2020

Intermolecular [4+2]/[3+2] radical annulation of N-methyl­anilines with alkynoates under metal- and photoredox-catalyst-free conditions provides a practical and efficient method to synthesize bioactive 1,4-dihydroquinolines and pyrrolo[1,2-a]quinolines in one pot in moderate to high overall yields.
Spectrum of Lysosomal Storage Disorders at Tertiary Centre: Retrospective Case-Record Analysis
Authors: Singh Ankur , Prasad Rajniti , Mishra Om Prakash
Published: January 2020

Lysosomal storage disorders (LSDs) are relatively common slow progressive inborn error of metabolism encountered by clinicians. This work intends to highlight the more common LSDs, their clinical presentation, outcome, and mutation (wherever feasible) collected from the genetic clinic at tertiary care center in Eastern Uttar Pradesh. The data for analysis were collected retrospectively from genetic records from a follow-up clinic. All cases < 18 years of age were analyzed. Cases with LSDs with confirmed enzyme results were enrolled in this study. Clinical profile, screening test results, and outcome were collected. There were 32 cases including 27 males and 5 females in this cohort: 8 Gaucher disease (GD) patient and 24 non-GD patients. GD (type 1) is the commonest LSD in GD group. Anemia, thrombocytopenia, splenomegaly, and hepatomegaly were the consistent finding in patients with GD (type 1). L483P mutation was reported in two GD patients. One GD patient is on enzyme replacement therapy for 2 years and is currently doing well. The commonest disorders in non-GD were mucopolysaccharidosis (MPS) (n = 11), metachromatic leukodystrophy (n = 4), I-cell disease (n = 3), Niemann-Pick A/B (n = 3). MPS-II is the commonest MPS among non-GD group.
Revision Multiligament Knee Reconstruction Surgery
Authors: Stuart Michael B. , Woodmass Jarret M. , Krych Aaron J. , Levy Bruce A. , Stuart Michael J.
Published: January 2020

Failed multiligament knee reconstruction is a challenging problem due to recurrent pathologic laxity that is often associated with limb malalignment, meniscus deficiency, articular cartilage insufficiency, decreased motion, compromised bone stock, and a paucity of graft sources. Revision surgical indications and techniques require a comprehensive evaluation of the patient, injury and treatment factors along with a focused physical examination and advanced imaging. A stepwise treatment approach can be effective in the evaluation of revision surgery and also in setting realistic patient goals.
Insight into picosecond kinetics of insulator surface under ionizing radiation
Authors: Rymzhanov R. A. , O'Connell J. H. , Janse van Vuuren A. , Skuratov V. A. , Medvedev N. , Volkov A. E.
Published: January 2020

We found experimentally and theoretically that MgO, CaF2, and Y3Al5O12 (YAG) irradiated with fast ions demonstrate a noticeably different surface response. Striking differences follow from the kinetics of nanodroplets ejection. Protrusion of the hot materials and subsequent recrystallization in MgO and CaF2 recover transient damage in the surface region, forming a spherically shaped nanohillock. YAG demonstrated almost no recovery of the transient disorder, forming an amorphous hillock. These differences are attributed to complex interplay between the mobilities of atoms in the hot region and surface tensions.
Acceleration of electron bunches in plasma wakefields generated by frequency-chirped laser pulse
Authors: Afhami Saeedeh , Eslami Esmaeil
Published: January 2020

A comparative study of different injection configurations in the wakefield generated by a chirped laser pulse is done. The preferable electron injection region is considered for different injection schemes. For injection in the chirped laser pulse region, the energy spread has approximately the same final value independently of its injection position while energy spread changes strongly for injection in the wakefield region. It is demonstrated that an externally injected electron bunch with an initial energy of 100 MeV can achieve an energy gain of 8 GeV by using periodical chirped laser pulses. In particular, strong bunch decoherence is observed for off-axis injection in a plasma-channel-guided-laser wakefield. This strong bunch decoherence leads to a considerable increase in the bunch emittance growth. The emittance growth in off-axis injection is at least ten orders of magnitude higher than in on-axis injection.
Dynamical analysis of a mean-field vector-borne diseases model on complex networks: An edge based compartmental approach
Authors: Wang Xiaoyan , Yang Junyuan
Published: January 2020

In this paper, we propose a concise method to investigate the global dynamics of a mean-field vector-borne diseases model on complex networks. We obtain an explicit formula of the basic reproduction number by a renewal equation. We show that the model exhibits a threshold dynamics in terms of the basic reproduction number by constructing subtle Lyapunov functions. Roughly speaking, if the basic reproduction number R0<1, the vector-borne diseases die out; otherwise, it persists. Moreover, numerical simulations show that vector-control is an effective measure for slowing down the spread of vector-borne diseases.
PT-symmetry entails pseudo-Hermiticity regardless of diagonalizability
Authors: Zhang Ruili , Qin Hong , Xiao Jianyuan
Published: January 2020

We prove that in finite dimensions, a Parity-Time (PT)-symmetric Hamiltonian is necessarily pseudo-Hermitian regardless of whether it is diagonalizable or not. This result is different from Mostafazadeh’s result [J. Math. Phys. 43, 205−214 (2002)], which requires the Hamiltonian to be diagonalizable. PT-symmetry breaking often occurs at exceptional points where the Hamiltonian is not diagonalizable. Our result implies that PT-symmetry breaking is equivalent to the onset of instabilities of pseudo-Hermitian systems, which was systematically studied by Krein et al. [Dokl. Akad. Nauk SSSR N.S. 73, 445 (1950)]. In particular, we show that the mechanism of PT-symmetry breaking is the resonance between two eigenmodes with opposite signs of actions.