bluuebunny/crossref_metadata_2025 huggingface dataset:
Cognitive decline in patients with essential tremor
Authors: Ermakova M. M. , Zalyalova Z. A.
Published: July 2023

Essential tremor (ET) is a heterogeneous disease with a high prevalence and disability. Traditionally, the disease was considered benign with the presence of tremor, the severity of which increases during the observation period. The severity of trembling varies widely from mild, not requiring therapy, to disabling. That is making difficulties to assess the prevalence of the disease. However, disability in patients with ET can occur not only due to the severity of tremor.The underestimated side of the disease, despite a long history of study, remains non-motor manifestations, including cognitive decline. Cognitive decline in essential tremor, compared with the general population, has a greater risk of transformation into dementia. In patients with ET, in comparison with other cognitive domains, executive functions are predominantly affected. Patients are also characterized by low awareness and concern about changes in intelligence. In the study of the brain using voxel morphometry, a heterogeneous group of changes that contradict each other was revealed. Most often, a change in the density of the cortex of different parts of the brain is detected in comparison with the control group. The most affected area of the brain is the precuneus. This may explain the executive dysfunction in patients and highlight the likely neurodegenerative nature of essential tremor. The absence of preventive therapy, the high incidence of changes in intelligence emphasizes the need for close monitoring of patients.
Dynamics of mental state and prolactin levels in patients with chronic schizophrenia during aripiprazole therapy
Authors: Gorobets L. N. , Dorovskikh I. V. , Litvinov A. V. , Bulanov V. S. , Gamdullaev S. K. , Pavlova T. A.
Published: July 2023

Introduction. Although scientific literature demonstrates a relationship between prolactin levels, the efficacy of aripiprazole therapy, and negative symptoms in patients with schizophrenia, many questions regarding these problems remain controversial.

Objective to study dynamics of clinical and hormonal parameters in patients with chronic schizophrenia during aripiprazole therapy.

Materials and methods: 60 patients with schizophrenia were studied: 42 male (70%) and 18 female (30%), aged 20 to 65 years (mean age 52.84±17.40 years) on inpatient aripiprazole treatment with the mean daily dosage of 15.33±4.52 mg. Comparative analysis of prolactin parameters was carried out taking into account the following factors: effectiveness of therapy, age, duration of the disease, severity of negative symptoms (according to the PANSS scores). Responders included patients with a reduction in total PANSS score of 20% and more.

Results: the effectiveness of aripiprazole monotherapy after switching from previous antipsychotic treatment in patients with chronic schizophrenia was noted in 71.7% of patients. The effectiveness of therapy does not depend on the background values of the hormone: at high rates, prolactin levels decrease, and at low rates, they increase. Meanwhile, a certain pattern was revealed between the dynamics of scores of the negative PANSS scale and the level of prolactin: responders with high background levels showed the decrease of prolactin levels given the decline of the PANSS scores, and in responders with low values, the hormone levels increased. In non-responders, low background scores of the negative scale and their slight changes during therapy were accompanied by an increase in prolactin levels. The data obtained in relation to non-responder patients who showed negative correlations between the levels of prolactin, age, dosage of the drug and the duration of the disease require a more careful attitude to the appointment of aripiprazole due to the likelihood of a decrease in their prolactin levels to abnormally low values.
From Publications of the Difficult Years of Soviet Psychiatry (quotes and comments)
Authors: Aleksandrovsky Yu. A.
Published: July 2023

The article presents excerpts from the documents of the past of domestic psychiatry. Their analysis allows, with the help of primary sources, to assess the difficult period of the middle of the last century in the development of biological science, scientific and practical psychiatry in our country. The intertwining of ideological, pseudoscientific, personal and career interests at that time, as in many areas of science, pushed aside the problems of creative scientific developments and created for many professionals an atmosphere of distrust, suspicion, and discredit of leading specialists.
Lógica difusa aplicada a la bolsa de valores
Authors: Talledo David
Published: July 2023

Objetivos: Proponer el uso de inteligencia artificial para reducir parcialmente la incertidumbre al invertir en la Bolsa de Valores. Demostrar, mediante el uso de lógica difusa, que con dicha propuesta es posible obtener resultados positivos y alta rentabilidad. Métodos: El enfoque de la investigación es cuantitativo experimental y cuali-cuantitativo descriptivo; se toma información micro y macroeconómica para experimentar con una acción de la Bolsa de Valores de Lima. Se analizan resultados cuali-cuantitativos de investigaciones previas. Resultados: Se demuestra que es posible utilizar inteligencia artificial para realizar mejores inversiones en la Bolsa de Valores. Además, se obtiene alta rentabilidad en el experimento. Conclusiones: El uso de inteligencia artificial y, específicamente, un algoritmo de lógica difusa, es efectivo para transmitir conocimiento, experiencia y reducir la incertidumbre al invertir en distintos mercados financieros. Sin embargo, aún hay mucho por desarrollar en este ámbito y ningún algoritmo debe considerarse como infalible.

Palabras clave: Ciencia de los Datos; Lógica Difusa; Bolsa de Valores; Inversión.
Study of the effect of arginine glutamate on cognitive processes in food-deprived rats
Authors: Kushta A. A. , Perminov D. O. , Melnyk A. V. , Voloshchuk N. I. , Taran I. V.
Published: July 2023

Annotation. In 2022, due to the COVID-19 pandemic and the aggravation of the food crisis, as a result of the full-scale Russian invasion of Ukraine, the share of the world's starving population has increased to 9.8% of the world's population. According to the literature, metabolic and neuroendocrine disorders during starvation have a negative impact on cognitive processes and social behavior. The aim of the study was to justify experimentally the feasibility of using glutargin for the correction of cognitive disorders in rats with partial food deprivation. The work includes such research methods as modeling of food deprivation according to the patented method, assessment of behavioral reactions and emotional state of rats using the "Open field" method, and study of working memory functions by the method of recognizing new objects. Statistical processing of the obtained results was carried out using non-parametric methods of analysis (MANOVA-test) using Statistica 6.0 software. Differences at p < 0.05 were considered significant. Partial food deprivation led to a decrease in the body weight of rats (about 30%, p<0.05), and an increase in the level of anxiety, which is evidenced by an increase in the average indicators of grooming by 53.7% and the average value of vertical activity by almost three times compared to the control group, a decrease in horizontal activity by 64.07%, which may be the result of a decrease in research activity and a decrease in interest to the environment. In contrast, in rats treated with glutargin, scores of anxiety were almost constant throughout the experiment. The test of recognition of new objects conducted at the end of the treatment shows that glutargin statistically significantly increased the coefficient of discrimination (CD), which indicated the restoration of nonspatial memory disorders that occurred in rats with experimental food deprivation. The obtained results are an experimental basis for further clinical studies devoted to the possibility of the practical use of glutargin in the complex treatment of patients with nutritional deficiency.
Psychoemotional disorders associated with pulmonary pathology in children, the role of serotonin, GABA and vitamin D in the pathogenesis of these disorders
Authors: Nevoia M. V.
Published: July 2023

Annotation. The present work aims to study psychoemotional disorders and somatoform autonomic dysfunction of the respiratory system in children-patients of the pulmonology department and to understand how serotonin, GABA, and vitamin D metabolism disorders contribute to their onset. The study involved 90 children with bronchial asthma (BA), community-acquired pneumonia, and somatoform autonomic dysfunction of the respiratory system (SADRS) aged 11,6±3,3 years, and 30 healthy children of the control group. The children’s depression inventory of M. Kovacs and Spielberger-Khanin was used to diagnose depression and anxiety. ELISA method was used to test blood serum for serotonin and vitamin D, and high-performance liquid chromatography to measure GABA levels. Probability was estimated using the t-test and construction of a 95% confidence interval (CI) for the difference in means, as well as correlation and regression analysis methods. In general, the level of serotonin in patients was lower compared to the control group (95% CI, 0,27 – 0,73 μmol/l, p<0,0001). The lowest level of serotonin was found in patients with BA (95% CI, 0,40 – 0,93 μmol/l, p<0,0001) and SADRS (95% CI, 0,32 – 0,82 μmol/l, p<0,0001) compared to the control group (95% CI, 0,2 – 8,0 ng/ml, p<0,04). Overall, a moderate and inverse correlation between serotonin levels and the severity of depression was found on the M.Kovacs scale where r -0,50 (р<0,0001), a strong and inverse correlation in patients with BA r -0,77 (р<0,022), and a moderate and inverse correlation r -0,55 (р<0,001) in patients with SADRS. A weak and inverse correlation was found between GABA levels and reactive anxiety on the Spielberger-Khanin scale, where r -0,25 (р<0,012) and a moderate and inverse correlation in patients with SADRS, where r -0,42 (p<0,01). Serotonin can play a key role in the development of anxiety and depressive disorders in children with respiratory pathologies. A low level of vitamin D in patients with SADRS may contribute to the development of the pathology. The correlation between the levels of GABA and the severity of reactive anxiety in general and in patients with SADRS, in particular, may suggest the indirect involvement of GABA in the development of anxiety.
The psychoemotional state of patients with oral mucosal diseases and the effectiveness of its correction
Authors: Muntian O. V. , Gadzhula N. G. , Muntian V. L. , Kurdysh L. F. , Gorai M. A.
Published: July 2023

Annotation. The work aims to study the psychoemotional state of patients with oral mucosal diseases and to evaluate the effectiveness of oral pathology treatment combined with psychological disorder management. Evaluation of the psychoemotional state of 48 patients with oral mucosal diseases was carried out using the Hospital Anxiety and Depression Scale (HADS). The assessment showed subclinical (mild) and clinically expressed (moderate) anxiety, as well as mild and moderate depression in pre-treatment patients. Based on the type of management, patients were divided into the main and comparison groups. The psychoemotional state of the patients of the main group was analyzed, and comprehensive treatment of oral mucosal diseases was administered, enhanced by psychological management. Patients of the comparison group underwent complex treatment of dental diseases with no psychological management. Statistical processing of the research results was carried out using generally accepted methods of variation statistics with the determination of the Student’s t-test and computer programs: “Statistica 6.1”, Microsoft® Excel 2017. Differences between the groups were considered statistically significant at p<0.05. The results of the study suggest that psychoemotional disorders lead to the development of oral mucosal diseases; at the same time, these oral diseases increase anxiety and depression. Hence, the treatment of patients suffering from oral mucosal diseases requires psychological management. After treatment, patients of the main group showed improved psychoemotional state and decreased clinical manifestations of oral mucosal diseases sooner than patients of the comparison group. Positive results of improving the psychoemotional state of patients with dental pathology invite inquiry into further study and improvement of the management strategies.
Dysfunction of the temporomandibular joints associated with post-traumatic stress disorders in patients
Authors: Syroishko M. V. , Kostiuk T. M.
Published: July 2023

Annotation. Temporomandibular joint disorders (TMJs) are among the most common maxillofacial pathologies found both in Ukraine and abroad, being comorbid in 75% of cases with other issues in dental patients. Psychoemotional disorders exacerbate the patient's perception of pathology and reduce the effectiveness of the treatment. Progressive exacerbation of TMJ symptoms associated with PTSD negatively affects patient-doctor relations and calls for the application of psychological and psychosomatic correction methods in addition to the standard multidisciplinary treatment and diagnostic algorithm. The purpose of the present research is to study and compare the nature and degree of psychological manifestations in patients with temporomandibular joint dysfunction associated with PTSD by examining the degree of clinical manifestations of the pathology to improve the quality of dental care. Examination and treatment of patients with TMJ dysfunction were carried out at the Dental Medical Center of NMU named after O.O. Bogomolets. The representative contingent of patients included 234 individuals. We used the modified FPS-R scale (based on Bayers), the short scale of anxiety, depression, and PTSD according to Hart, the Giessen Questionnaire of Somatic Complaints, projective technique. The results of the study made it possible to note significant changes in the patients’ subjective perception of their feelings in each individual clinical group. In the II clinical group, which underwent the greatest changes, the percentage of feeling pain as too strong and unbearable increased by 3.9 and 4.2%, respectively, in the III clinical group, one was struck by the complete presence (100%) of pain complaints of various intensity, periodicity and the nature of the pain picture. Thus, general somatic and emotional-psychological components of the pathology became dominant along with the main changes in the neuromuscular and occlusive-articulatory components of the TMJ biosystem due to post-traumatic stress disorder.
Parameters of intra-cardiac hemodynamics in women with essential hypertension and heart failure, carriers of different polymorphic variants of the galectin-3 gene (LGALS-3, rs 2274273)
Authors: Polishchuk T. V. , Zhebel V. M.
Published: July 2023

Annotation. The study aims to improve the prediction and diagnostics of cardiac remodeling, specifically left ventricular myocardial hypertrophy (LVH) in essential hypertension and the development of chronic heart failure (CHF) in carriers of polymorphic variants of the galectin-3 gene (LGALS-3, rs2274273). 180 postmenopausal women, on average aged 58.51±0.45, residents of the Podillya region of Ukraine, were examined. The main group consisted of 113 women with EH, of which 62 had EH II, and 51 had EH III with CHF II A stage. The control group included 67 women without signs of cardiovascular pathology. General clinical examination, enzyme immunoassay method for determining the level of galectin-3 in blood plasma, genotyping of the LGALS3 gene (rs2274273) using polymerase chain reaction, and ultrasound of the heart were performed. Compliance of the frequency distribution of genotypes in the studied populations to the Hardy-Weinberg equilibrium was checked using the MedCalc Software Ltd. Odds ratio calculator. https://www.medcalc.org/calc/odds_ratio.php and calculated the odds ratio (OR) of developing left ventricular myocardial hypertrophy (LVH) and chronic heart failure (CHF). OR = 1 was considered as no association, OR>1 – as a positive association (increased risk of pathology), and OR<1 – as a negative association (reduced risk of pathology). The results were considered reliable at p<0.05. Statistical processing of the obtained results was performed using the SPSS statistical program package, STATISTICA v. 10.0. The reliability of the difference in percentages of quantitative values between groups was calculated according to the χ2 criterion. In postmenopausal women, residents of the Podillya region of Ukraine, without signs of cardiovascular pathology, the following frequency distribution of galectin-3 gene genotype variants (rs2274273) was found: GA – 49.25%, GG – 40.30%, AA – 10.45%, which corresponds to the Hardy-Weinberg equilibrium. The specified ratio does not reliably differ from that in women with EH of different stages. Therefore, the galectin-3 gene polymorphism (rs2274273) is not associated with the risk of EH: OR =0.88; 95% CI 0.47 – 1.63; z statistic 0.417; χ2 =0.1744, p=0.6763. Analysis of the structural and functional parameters of the myocardium in carriers of the A allele shows more pronounced remodeling of the myocardium with eccentric LVH, a more advanced diastolic dysfunction (DD), and lower left ventricular ejection fraction than in GG homozygotes (LVEF 47.63±0.49% vs. 50.61±0.63%, p<0.05). Therefore, the GG genotype of the galectin-3 gene (rs2274273) is a marker of limited changes in the structure of the myocardium in EH.
Prognosis of the clinical course of portal hypertension complicated by the acute variceal bleeding
Authors: Kedyk O. O.
Published: July 2023

Annotation. Variceal bleeding is one of the most dangerous complications of liver cirrhosis, which is associated with relatively high lethality. At the same time, the bleeding can trigger some other complications of liver cirrhosis that further worsen the prognosis for these patients. These factors determine the necessity not only for the diagnosis of variceal bleeding in patients with liver cirrhosis but also for the prognosis of possible recurrent bleeding and lethality. The aim of this study was to evaluate the possibility of predicting survival or lethality in patients with variceal bleeding. This study is based on the results of the investigation and treatment of 121 patients with liver cirrhosis complicated by variceal bleeding. To determine the prognostic value of the clinical course, the analysis of various markers of complete blood count, biochemical blood and coagulation markers, Child-Turcotte-Pugh and MELD criteria was performed. The ROC (receiver operating characteristic) curve was applied for the evaluation and comparison of various markers. Additionally, the specificity, sensitivity, accuracy, positive (PPV) and negative prognostic value (NPV), positive (LR+) and negative (LR-) likelihood ratio were used. The J-index (index Youden) was applied for the comparison of border values. Predicting the clinical course allows for identifying patients with a possible unfavorable prognosis who require intensive therapy, as well as those with minimal risk of fatal outcome. According to the study results, the International normalized ratio (sensitivity – 95%, specificity – 97%), potassium blood level (sensitivity – 95.2%, specificity – 89%), and MELD score (sensitivity – 95.2%, specificity – 86%) are the markers, which had the highest prognostic value for the unfavorable clinical course. Whereas the sodium blood level (sensitivity – 96%, specificity – 100%) was the best marker of favorable clinical course. Other analyzed indicators had limited prognostic significance. Thus, although the number of bleedings in the anamnesis increases the risk of a fatal outcome, it has limited importance for prognostics of a favorable or unfavorable course of variceal bleeding. The sodium blood level is the best marker for the prediction of a favorable clinical course. International normalized ratio, potassium blood level, and MELD score are the markers of an unfavorable clinical course.
Substantiation of recommendations for safe aerial application of pesticides used by unmanned aierial vehicles (UAVs)
Authors: Borysenko А. А. , Antonenko А. М. , Omelchuk S. T. , Bardov V. G. , Aleksiichuk V. D.
Published: July 2023

Annotation. UAVs have many advantages over traditional aerial application methods, including greater accuracy, efficiency, availability, cost-effectiveness, and safety, as well as improved data collection and real-time monitoring. The absence of appropriate rules and regulations that would govern the use of agrodrones can jeopardize the health of people, animals and plants, and can also negatively affect environmental objects. The aim is to substantiate recommendations for the safe aerial application of pesticides using unmanned aerial vehicles (UAVs). Field research was conducted in the Vinnytsia, Kyiv, and Zhytomyr regions of Ukraine in 2019-2022 using the most common models of agricultural drones DJI Agras T16 and XAG XPlanet 2020. Statistical processing of the results was carried out using a package of licensed statistical programs IBM SPSS Statistics Base v.22, Jupyter Notebook 6.4.8 and Python 3.11. Based on studies we have conducted, we recommend maintaining the following protective zones for various objects: 500 m from settlements, animal husbandry complexes, work sites dedicated to the manual care and cultivation of agricultural crops, reservoirs and recreational areas; from fishing reservoirs, open sources of water supply, grazing places for domestic animals, objects of the nature reserve fund, areas for sowing crops that are used for food without heat treatment – 2 km; from the place of permanent residence of honey bees – 3 km. If there are apiaries near the location of aerial application, it is necessary to notify the beekeepers in advance 12 hours before the start of application, so that the beekeeper has time to take measures for the safety of the bees. The point of remote piloting of the UAV (ground control station of the drone and refueling of the sprayer tank) must be located at a distance of at least 25 m from the field border. Thus, we have developed recommendations that will simplify the use of agricultural drones, a promising technique for the agro-industrial complex, while minimizing risks for workers, the population, and the environment. The hygienic aspect of the use of UAVs needs further comprehensive and detailed study.
Analysis of the dependence of the balance sheet values of costs, quality and comfort of medical services on the individualized elasticity of patient demand
Authors: Klymenyuk O. V. , Ocheredko O. M. , Klymenyuk V. P. , Rudenko A. A.
Published: July 2023

Annotation. Various types of co-payments are being actively implemented in the Ukrainian healthcare system. These changes determine the relevance of the study, which aims to investigate the support of quality and comfort of medical services, in particular through the introduction of co-payments. A combined study was conducted of the main array of gynaecological inpatient services in Vinnytsia. The purpose of the study was to test the hypothesis of simultaneous changes in the balance values of costs, quality and comfort of healthcare services, in particular as a result of changes in the elasticity of demand for these attributes. A decrease in the individualised elasticity of demand for price, quality and comfort due to the patient's lack of awareness of costs, quality and comfort leads to a decrease in the corresponding balance values of costs, quality and comfort. 150 medical records of inpatients of gynaecological departments with the main diagnoses of uterine cysts and/or fibroids in three medical diagnostic institutions in Vinnytsia were analysed in the course of the study. The study empirically verified a theoretical model (D. Dranov and M. Satterthwaite) based on the behaviour of a provider who tries to maximise profits within certain limits (set by demand) by manipulating three important attributes: price, quality of service and comfort. It has been established that the balance sheet values of the costs of medical services are significantly higher with better awareness of patients, i.e. higher with an increase in the individual elasticity of demand for a price. Higher book values of expenditures on healthcare services are associated with a higher quality of healthcare services, which, according to the factor loadings, correlates with higher complexity of services. At higher balance values of healthcare costs, the comfort of healthcare services is significantly higher, with discomfort correlating with more complex pathology and the need for higher complexity and volume of services.
The mechanisms of the extracellular matrix remodeling of myocardium among patients with hypertension
Authors: Kulbachuk O. S. , Sid E. V. , Soloviov O. V. , Piskun A. V. , Marchenko-Antudze O. O.
Published: July 2023

Annotation. The present review article highlights the central mechanisms that contribute to the extracellular matrix remodeling in the myocardium among patients with hypertension. Based on the scientometric databases Web of Science, Scopus, and PubMed, a retrospective analysis of the literature issued in 2010-2022 on this specific topic was conducted. After reviewing the article abstracts and getting acquainted with their full text, we selected 30 sources. The search results suggest that under physiological conditions, collagen ensures structural integrity by preventing excessive stretching of cardiomyocytes. It was established in the course of the research that progressive vascular fibrosis occurs due to excessive collagen synthesis relative to its degradation by metalloproteinases. Metalloproteinases play a central role in the exchange of connective tissue proteins. Cytokinins such as tumor necrosis factor alpha and interleukin-1β contribute to the accumulation of collagen in the intercellular space, aldosterone being another contributor to the process. It has been noted that hypertensive disease is associated with high activity of angiotensin-II, which regulates the expression of β-transforming growth factor and has pro-fibrotic properties. Biological molecules of catecholamines, as well as molecules of aldosterone and angiotensin-II, affect the activity of MMP by suppressing NO activity in the vessel wall. An understanding of various pathophysiological mechanisms involved in hypertension leading to vascular dysfunction and myocardial remodeling as well as changes in the extracellular matrix of the myocardium can prove to be essential for identifying critical pharmacological targets. The priority of prescribing specific groups of antihypertensive drugs remains uncertain at the moment, but special attention is paid to their effect on the inhibition and reversal of the development of myocardial and vascular fibrosis. Thus, the study of the activity of enzymes of the metalloproteinase family is promising for clinical studies in hypertension.
The impact of today’s chronic stress on a woman’s menstrual function
Authors: Lovkina O. L. , Masibroda N. G. , Muntyan O. A. , Klivak V. V. , Vozniuk A. V.
Published: July 2023

Annotation. The article presents a review of the scientific literature on the problem of menstrual dysfunction under the influence of chronic stress. The war has caused the most severe stress for the Ukrainian population in recent months. Women have faced increased workloads, stressful situations, and poor nutrition and hygiene. The combination of all these factors has affected women’s health, especially their reproductive system. Since the beginning of the war, 53.4% of women have noticed changes in their normal menstrual cycle. They reported moderate to heavy bleeding associated with pain, irregular cycles, feeling weak and fatigue, which is a sign of abnormal uterine bleeding (AUB). The regulation of the menstrual cycle is a multi-stage “cascade”, the upper level of which is the cerebral cortex and structures of the limbic system (hippocampus, amygdala). Neuropeptides (dopamine, norepinephrine, serotonin, and kisspeptin) and the hormone melatonin are central to this process. Stressful situations directly affect the synthesis and use of neurotransmitters and hormones, disrupting the most important link in the regulation of the menstrual cycle. During the war, many women faced threats to their lives and health, which led to psycho-emotional distress that negatively affected many aspects of reproductive health. The purpose of our work was to search, systematize and analyze relevant scientific sources and view online conferences and webinars on menstrual disorders under the influence of chronic stress. We conducted a systematic review and an analysis of the relevant literature and video materials over the past year. We used PubMed and Google Scholar to search for data. Search words “stress”, “menstrual cycle”, “war”, and “abnormal uterine bleeding” were used to query data. Analysis of the collected data suggests that the problem of menstrual disorders is very relevant today because most women today are affected by chronic stress.
Is there a relationship between alopecia and anthropometric indicators? Modern scientific view
Authors: Shakatira M. A. M.
Published: July 2023

Annotation. Alopecia is a widespread disease that affects different strata of the population by age, gender, socio-economic status and causes pathological hair loss on the human body. First of all, attention is drawn to the loss of hair follicles on the head, which causes significant psychological discomfort in these patients. Complex pathogenesis, high costs of treatment and lack of etiotropic treatment require a comprehensive review of this pathology. One of such promising, but underestimated directions is anthropometric, which involves the study of height, weight, circumferences and other parameters of the human body. The purpose of the study is to conduct a review of literary sources for the period 2013-2023, which is related to human anthropometric indicators and alopecia, using the inclusion and exclusion criteria for the analysis of publications. Taking into account the criteria for inclusion in the review, an analysis of 33 literary sources was carried out. The result of summarizing the research data shows that for many diseases of the skin and its appendages, anthropometric indicators have been identified, which allow forming risk groups of the occurrence or severity of the course of the disease. The results related to the analysis of samples of patients with one or another form of alopecia show that this disease is characterized by pronounced manifestations of sexual dimorphism in relation to anthropometric indicators, and most often correlations relate to such indicators as weight, body mass index, and waist circumference. Thus, the analysis of literary sources proves that there is a need to conduct an anthropometric study of representatives of the Ukrainian nationality suffering from alopecia of various genesis in order to further identify indicators that can be used to predict the risk of occurrence and course of this disease. During the research, it is necessary to pay special attention to the formation of a homogeneous sample according to the most key indicators, such as age, sex, concomitant diseases, type of alopecia, etc. In the future, it is planned to carry out a clinical study on a sample of people, residents of the Podillia region of Ukraine, suffering from alopecia.
The subventricular zone of the lateral ventricles in the postnatal neurogenesis
Authors: Damzin O. S. , Tykholaz V. O. , Galunko G. M.
Published: July 2023

Annotation. The primary aim was to analyze the scientific and theoretical material regarding the morphological and immunohistochemical characteristics of the subventricular zone’s structure in the lateral ventricles during postnatal neurogenesis and to determine the prospects for further research. Given that neuronal development takes place in this specific part of the brain throughout the entire period of human ontogenesis, understanding its morphological and histological structure will help to clarify the mechanisms of neurogenesis under normal circumstances as well as under the influence of various physiological or pathological factors, which determines the relevance of this study. 40 sources on this topic were reviewed and selected from the main scientometric databases like Web of Science, PubMed, Scopus, and Web of Knowledge, with the majority of publications coming from the last decade. The state of research related to the morphogenesis and histogenesis of the subventricular zone of the lateral ventricles of the animal brain in postnatal neurogenesis is highlighted, and the ways of further research are determined as a result of the scientific and theoretical analysis of literature sources.
Vasyl Danylovych Bilyk – rector, honorary citizen of the city of Vinnytsia. To the 100th anniversary of the birth
Authors: Yurchyshyna O. A.
Published: July 2023

Annotation. The article highlights the life and scientific path of V. D. Bilyk, a well-known neurologist, rector of the Vinnytsia State Medical Institute named after M. I. Pirogov (1974-1988), a participant in the Second World War and his contribution to the development of the university.
The Parenting of Single Parents in Forming Discipline for Ibtidaiyah Madrasah Students
Authors: Satriawati Satriawati , Rokhman Mauhibur , Saputra Nanda , Anggraini Sitti , Abou-Samra Reem
Published: July 2023

This article is motivated by student discipline records that show promising results. This disciplinary background cannot be separated from how single parents educate students in the family. This condition is certainly not in line with the theory of student discipline, where students with good discipline come from families that are intact and compact in educating their children. This article aims to find out and describe the Single Parent Parenting Pattern in Shaping the Discipline of MI Darussalam Pacet Mojokerto Students and the Causes of Single Parenting Patterns in Shaping the Discipline of MI Darussalam Students Pacet Mojokerto. This article has used a qualitative type with a case study approach centered on one well-disciplined student with divorced parents. The results of this study are 1) Parenting applied by single parents to students using a combination of authoritarian and authoritative parenting. 2) The causal factors are classified into internal and external.
ANALISIS PENGEMBANGAN JARINGAN SPAM DALAM MEMENUHI KEBUTUHAN AIR DI DESA BERGAS LOR KECAMATAN BERGAS KABUPATEN SEMARANG
Authors: Haji Son , Wanto Sri , Lestari Fitria Maya , Mahmud Faizal , Widiatmoko Kukuh Wisnuaji
Published: July 2023

Air bersih yang digunakan sehari-hari harus memiliki kualitas yang baik untuk konsumsi sesuai dengan standar air minum di Indonesia yaitu PP No.82 Tahun 2001 dan KepMen No.907 Tahun 2002. Secara umum kebijakan pemerintah dalam bidang pembangunan prasarana penyediaan air bersih direalisasikan dengan membangun sistem perpipaan.  Beberapa sumber air baku yang dapat digunakan untuk penyediaan air minum antara lain air hujan, air permukaan, mata air, air tanah. Penggunaan air dalam kehidupan sehari-hari sangat beragam tergantung dari jenis pemakaiannya. EPA NET adalah program komputer yang secara luas melakukan periode simulasi dari hidrolika dan kualitas air dalam jaringan pipa bertekanan. Jaringan tersebut dapat terdiri dari sumber air, tangki penyimpanan atau reservoir, pipa, titik percabangan pipa, pompa, dan katup. EPA NET juga dapat mensimulasikan konsentrasi zat kimia yang ditambahkan pada suatu jaringan, umur air dan pola outflow dari sumber air. Dari hasil simulasi pemodelan program epanet 2.2 dengan periode waktu 72 jam diperoleh debit air yang dibutuhkan untuk menuhi 1570 jiwa jumlah penduduk sebesar 2,56 lt/detik,  sisa tekan minimum 1,64 meter kolom air di Patok 30 pada jam puncak pada (di seting padan jam 08.00 ). sisa tekan masimum 22,86 meter kolom air di Patok 8 pada jam puncak (di seting padan jam 08.00 ). kecepatan air dalam pipa minimum sebesar 0,03 m/detik dan maksimum 1,31 m/detik. Untuk memenuhi kebutuhan air dengan jumlah jiwa 1750 dengan kebutuhan air rata sebesar 2,03 liter/detik diperlukan kapasitas Bak penampung sebesar 20 m3.
DAMPAK KEBERADAAN JALAN TOL TERHADAP TRANSPOTASI YANG MELINTASI DI JALUR PANTURA
Authors: Wahyudiono Wahyudiono , Perandana Frendy
Published: July 2023

ABSTRAKDampak ekonomi dari infrastruktur transportasi secara umum diterima dalam teori di mana dijelaskan bahwa investasi transportasi mempunyai pengaruh yang kuat dan positif pada output ekonomi di tingkat nasional atau negara bagian. Pemerintah Indonesia pada periode 2015-2019 gencar untuk melaksanakan pembangunan infrastruktur jalan tol di berbagai wilayah salah satunya adalah jalan tol Trans Jawa. Setelah beroperasinya jalan tol Trans Jawa wilayah yang berada di jalur pantura Jawa mengalami perubahan aktivitas ekonomi yang berbeda-beda. Penelitian ini bertujuan untuk mendeskripsikan perkembangan wilayah pada aspek ekonomi antara kondisi sebelum dan setelah beroperasinya jalan tol dan mengidentifikasi faktor-faktor yang mempengaruhi perkembangan wilayah tersebut. Penelitian ini dilakukan dengan menggunakan metode studi kasus. Hasil penelitian menunjukkan bahwa pembangunan jalan tol lebih banyak dinikmati oleh wilayah yang merupakan tujuan pergerakan, sedangkan pada wilayah yang bukan merupakan tujuan pergerakan cenderung kurang diuntungkan dengan terjadinya penurunan aktivitas ekonomi setelah beroperasinya jalan tol. Penelitian ini juga menemukan bahwa jalan tol berpengaruh terhadap peningkatan penerimaan pajak daerah dan banyaknya kendaraan truk yang tidak menggunakan jalan tol karena mahalnya tarif tol. Faktor-faktor yang mempengaruhi perkembangan wilayah setelah beroperasinya jalan tol dan juga berpengaruh terhadap per ekonomian jalur pantura di antara nya para pedagang kuliner maupun rumah makan yang banyak di sepanjang jalur pantura mengalami penurunan omset, dikarenakan mobilitas kendaraan pribadi cendurung lewat jalan yang bebas macet dan jangkauan lebih efektif.
STABILISASI TANAH LEMPUNG MENGGUNAKAN CAMPURAN ABU SEKAM PADI DAN SEMEN DI TINJAU TERHADAP NILAI CBR DI KECAMATAN MARABAHAN KABUPATEN BARITO KUALA
Authors: Adawiyah Robiatul , Haris Haris , Gazali Akhmad
Published: July 2023

Tanah merupakan bahan yang penting untuk diperhatikan dalam membangun suatu kontruksi. Salah satu jenis tanah bermasalah yang umum ditemui di Indonesia adalah tanah lempung. Selain tanah dengan daya dukung yang rendah, tanah lempung juga memiliki sifat kembang susut yang besar serta plastisitas yang tinggi. Tanah dasar di Kecamatan Ulu Benteng, Kabupaten Barito Kuala, Provinsi Kalimantan Selatan. Perlu dilakukan analisa lebih lanjut karena terindikasi tanah lempung Oleh karena itu, perlu dilakukan perbaikan terhadap sifat-sifat tanah lempung. Upaya perbaikan tanah yang bisa dilakukan yaitu menggunakan cara stabilisasi tanah dengan komposisi campuran abu sekam padi dan semen 10% 15% dan 20% dengan perbandingan 1:1 terhadap berat sampel. Pengujian dalam penelitian ini meliputi sifat fisik, pemadatan standar, pengujian CBR tanpa rendaman dengan pemeraman 0, 4, 7, 14, 28 hari dan CBR Rendaman 4 hari. Hasil pengujian CBR tertinggi dari tanah campuran dengan presentasi 20% adalah sebesar 19% pada titik 1 dan 20% pada titik 2. Nilai CBR tersebut mengalami presentasi kenaikan 295% pada titik 1 dan dan 300% pada titik 2 dari nilai CBR tanah asli. Dari hasil terbsebut menunjukan bahwa penambahan abu sekam padi dan semen mampu memperbaiki nilai daya dukung tanah lempung.
EFEK KONDISI INISIAL KADAR AIR TERHADAP KADAR AIR OPTIMUM DAN KEPADATAN KERING MAKSIMUM PADA TANAH BUTIR HALUS TERKOMPAKSI
Authors: Nugraha Andrias Suhendra
Published: July 2023

Kompaksi adalah proses pemadatan tanah dengan menggunakan energi mekanik yang dipengaruhi oleh modifikasi kadar air untuk meningkatkan kekuatan (strength) dari suatu tanah yang digunakan sebagai pavement subgrade. Tujuan dari penelitian ini adalah untuk memahami pengaruh kondisi inisial dari kadar air terhadap kadar air optimum (OMC) dan kepadatan kering maksimum (MDD) dari tanah berbutir halus terkompaksi di laboratorium. Tanah uji yang digunakan pada penelitian ini berasal dari dua lokasi di Jawa Barat yaitu: area Lembang – Bandung dan area Gn. Salak – Bogor. Uji kompaksi menggunakan energi kompaksi standard Proctor yang mengacu pada standar ASTM D 698. Terdapat dua kondisi inisial untuk kadar air dari tanah uji yaitu; kondisi air dried dan kondisi natural. Hasil penelitian menunjukkan bahwa tanah Lembang maupun tanah Gn. Salak diklasifikasikan sebagai tanah berbutir halus dengan kadar air natural tinggi. Pada kondisi inisial kadar air air dried, walaupun memiliki perbedaan nilai OMC sebesar 15% (54% untuk tanah Lembang dan 39% untuk tanah Gn. Salak), tetapi nilai MDD untuk kedua tanah hampir sama yaitu 1.00 t/m3 untuk tanah Lembang dan 1.07 t/m3 untuk tanah Gn. Salak. Pada kondisi inisial kadar air natural, OMC dan MDD untuk tanah Lembang dan tanah Gn. Salak sulit untuk ditentukan karena tidak diperolehnya titik puncak dari kurva kompaksi.
STUDI ANALISIS DAYA DUKUNG DAN PENURUNAN PONDASI MINI PILE PADA PEMBANGUNAN GEDUNG KANTOR DINAS SATUAN POLISI PAMONG PRAJA KABUPATEN TAPIN
Authors: Gazali Akhmad , Adawiyah Robiatul , Nordina Husna
Published: July 2023

Pondasi adalah struktur bagian bawah bangunan yang terletak di bawah permukaan tanah yang berfungsi untuk memikul beban bangunan di atasnya. Penelitian ini berlokasi di Kabupaten Tapin Pada Bangunan Kantor Dinas Satuan Polisi Pamong Praja. Adapun penelitian ini bertujuan untuk mengetahui besar daya dukung pondasi mini pile dengan variasi dimensi menggunakan 2 metode, yaitu metode Meyerhoff dan metode Aoki de Alencar. Selain itu, juga untuk mengetahui punurunan dengan variasi dimensi tersebut menggunakan metode Paulus Davis. Berdasarkan hasil penelitian menggunakan metode Meyerhoff diperoleh daya dukung pondasi mini pile yang paling efektif pada variasi dimensi 20 cm × 20 cm (S-1) sebesar Qu1 = 157,2 ton dan (S-2) sebesar Qu2 = 113,92 ton sedangkan penurunan yang paling kecil pada variasi dimensi 30 cm × 30 cm dengan nilai (S-1) sebesar S1 = 3,25 mm dan (S-2) sebesar   S2 = 4,36 mm.
PENERAPAN BUILDING INFORMATION MODELING (BIM) PADA PEKERJAAN PADA GEDUNG BERTINGKAT RUMAH SUSUN BBPJN XI/PJN I KALIMANTAN
Authors: Purnamasari Eka , Maulana Muhammad Luthfi , Gazali Akhmad
Published: July 2023

ABSTRAKBangunan Gedung Rumah Susun BBPJN XI/PJN I Kalimantan terdiri dari 9 lantai dengan material beton bertulang. Penelitian bertujuan menerapkan Building Information Modeling (BIM) dalam analisis  struktur  atas  dan estimasi volume  pekerjaan  pada gedung  bertingkat, karena memiliki fitur-fitur yang dapat diandalkan untuk perencanaan dan meminimalisir kesalahan dalam estimasi volume pekerjaan. Penelitian memanfaatkan Tekla Structural Designer dan Tekla Structures, yaitu perangkat lunak BIM yang terkemuka dalam industri konstruksi, sebagai alat untuk memodelkan struktur gedung bertingkat secara detail. Dalam metode ini, analisis struktural dilakukan untuk memastikan kekuatan dan kestabilan struktur menggunakan metode elemen hingga dengan acuan desain SNI 1727-2020 dan SNI 2847-2019. Fitur Tekla Structures, seperti organizer digunakan untuk menghitung volume pekerjaan yang dibutuhkan untuk masing-masing komponen struktural. Berdasarkan hasil perhitungan kombinasi pembebanan didapat nilai gaya aksial terbesar terdapat pada kolom K58 (Kode C24-1) sebesar 4910,6 kN, kemudian untuk gaya momen terbesar ada pada balok B57 (Kode 9B6) sebesar 291,8 kNm, dan untuk nilai gaya geser terbesar terdapat balok B46 (Kode 9B6-3) sebesar -237,9/225,1kN. Pekerjaan struktural kolom dan balok seluruhnya aman. Adapun hasil estimasi volume pekerjaan pada beton serta besi kolom berturut-turut sebesar 517,8 m3 dan 260.281 Kg, selanjutnya, untuk volume pekerjaan beton serta besi balok berturut-turut sebesar 290,7 m3 dan 90.720 Kg.
PERENCANAAN PERKERASAN JALAN MALIJO DENGAN KONSTRUKSI DAUR ULANG DI KABUPATEN KOTAWARINGINBARAT
Authors: Tarip Tahan
Published: July 2023

Sarana infrastruktur jalan memiliki peranan penting untuk menunjang kegiatan masyarakat di bidang ekonomi maupun kegiatan sosial lainnya. Ketersediaan jalan yang baik dan stabil sangat berpengaruh terhadap kelancaran arus lalu lintas. Jalan Malijo Kabupaten Kotawaringin Barat merupakan jalan kabupaten yang memiliki lalu lintas harian yang tinggi karena sering kali dilewati kendaraan berat. Dengan adanya permasalahan tersebut, maka metode yang dapat diterapkan yaitu metode perkerasan CTRB. Tujuan dari perencanaan ini adalah untuk mengetahui tebal perkerasan Jalan Malijo Kabupaten Kotawaringin Barat Provinsi Kalimantan Tengah, dengan menggunakan konstruksi Daur Ulang/CTRB. Dengan menggunakan data primer yang melakukan pengamatan langsung di lapangan yaitu data Lalu Lintas Harian Rata – rata (LHR) dan menggunakan data sekunder yaitu dara CBR dan Curah Hujan. Dari perhitungan yang telah dilakukan menunjukkan bahwa hasil desain menggunakan konstruksi CTRB dengan lapis permukaan lataston 9 cm, Lapis Penambahan Aggregat 15,5 cm, Lapis Pondasi Atas (CTRB) 20 cm, Lapis pondasi bawah 10 cm dengan nilai CBR tanah dasar rata – rata sebesar 5,33 % serta CBR karakteristik sebesar 4,8%.
Production and Evaluation of Biodiesel from Sheep Fats Waste
Authors: Salih Abbas Ammar , Salah Othman Toleen
Published: July 2023

Animal fats are a good, promising and ethical alternative source for biodiesel production, but they need more complex treatments than vegetable oils. Iraqi butchery plants waste fats (sheep fat) which are suggested as feedstock to produce biodiesel. This type of fat contains a large quantity of free fatty acids (FFAs) (acid number 49.13 mg KOH/g of fat). The direct transesterification of such fats produce high amount of soap instead of desired biodiesel, so a pre-treatment step (to reduce FFAs) is necessary before transesterification. This step was done by esterification of the free fatty acids in the fat by adding ethanol and using 1% acid catalyst (H2SO4) for 30 minutes. The results showed that the acid number of sheep fat after pre-treatment step reduced to 0.97 mg KOH/g of fat at esterification step. Transesterification of treated fats (produce from esterification) used to convert biodiesel. The maximum yield of biodiesel was about 85 vol. % for treated fats obtained with 25/100 ethanol/fat wt. ratio, 70° C reaction temperature and 50 minutes total treatment period (pre-treatment step and transesterification reaction). The suggested model of the production rate kinetic of transesterification reaction, found that the production rate is inversely proportional with the volume of biodiesel produced with activation energy of 25320 J/mole.
Phenyl Thiourea as Corrosion Inhibitor for Mild Steel in Strong Hydrochloric Acid
Authors: S. Yaro Aprael , A. Abdulaaima Dhuha
Published: July 2023

The inhibitive action of Phenyl Thiourea (PTU) on the corrosion of mild steel in strong Hydrochloric acid, HCl, has been investigated by weight loss and potentiostatic polarization. The effect of PTU concentration, HCl concentration, and temperature on corrosion rate of mild steel were verified using 2 levels factorial design and surface response analysis through weight loss approach, while the electrochemical measurements were used to study the behavior of mild steel in 5-7N HCl at temperatures 30, 40 and 50 °C, in absence and presence of PTU. It was verified that all variables and their interaction were statistically significant. The adsorption of (PTU) is found to obey the Langmuir adsorption isotherm. The effect of temperature on the adsorption process showed that the adsorption process is exothermic, spontaneous and represents mixed chemical and physical adsorption for PTU on the metal surface.