bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure 1 from Endoneurial Macrophages Induce Perineural Invasion of Pancreatic Cancer Cells by Secretion of GDNF and Activation of RET Tyrosine Kinase Receptor
Authors: Cavel Oren , Shomron Olga , Shabtay Ayelet , Vital Joseph , Trejo-Leider Leonor , Weizman Noam , Krelin Yakov , Fong Yuman , Wong Richard J. , Amit Moran , Gil Ziv
Published: March 2023

PDF file - 112K, The ability of EMPhis to invade in a matrigel matrix towards a colony of PDA cancer cells.(a) An illustration showing the calculation of the invasion distance. (b) A photograph of the assay showing that the invasion of EMPhis was more prominent towards the cancer colony than to the other direction (magnification X4). Cancer cells were differentiated from EMPhi by morphologic criteria. (c) Analysis of the results of the invasion assay showing significantly higher migration towards the tumor colony (a- blue bar) compared to the opposite directions (g and beta - red bars, P<.001, n=10).
Supplementary Figure 6 from Immune Response Is an Important Aspect of the Antitumor Effect Produced by a CD40L-Encoding Oncolytic Adenovirus
Authors: Diaconu Iulia , Cerullo Vincenzo , Hirvinen Mari L.M. , Escutenaire Sophie , Ugolini Matteo , Pesonen Saila K. , Bramante Simona , Parviainen Suvi , Kanerva Anna , Loskog Angelica S.I. , Eliopoulos Aristides G. , Pesonen Sari , Hemminki Akseli
Published: March 2023

PDF file - 128K, T-cell analyses in C57Bl/6 mice bearing B16-Ova tumors C57Bl/6 mice bearing B16-Ova tumors were injected intratumorally. Lymph nodes, spleens and tumors were collected 8 days after first virus injection, homogenized and cultured for 24 hours. Analysis of Ova-specific CD8+CD19- was performed by flow cytometry gating the CD19- population and plotting SIINFEKEL marker of Ova with CD8. Results are represented as percentage of double positive CD8 and SIINFEKEL peptide and plotted as mean +SEM. *, P<0.05.
Supplementary Methods, Figures 1 - 13 from DDB2 Suppresses Epithelial-to-Mesenchymal Transition in Colon Cancer
Authors: Roy Nilotpal , Bommi Prashant V. , Bhat Uppoor G. , Bhattacharjee Shaumick , Elangovan Indira , Li Jing , Patra Krushna C. , Kopanja Dragana , Blunier Adam , Benya Richard , Bagchi Srilata , Raychaudhuri Pradip
Published: March 2023

PDF file - 13093K, Supplementary Fig.1: Loss of DDB2 expression in human colon cancer. Supplementary Fig.2: Low magnification IHC data showing reduced expression of DDB2 in high grade colon cancer samples. Supplementary Fig.3: Depletion of DDB2 increases invasivness of colon cancer cells. Supplementary Fig.4: Polyclonal DDB2 knockdown colon cancer cells exhibit increased tumorigenicity Supplementary Fig.5: Polyclonal DDB2 knockdown colon cancer cells exhibit EMT Supplementary Fig.6: DDB2 knockdown colon cancer cells generate aggressive tumors in nude mice Supplementary Fig.7: Low magnification picture showing EMT in xenografted tumors Supplementary Fig.8: DDB2 expression blocks EMT induced by hypoxia and TGF-beta Supplementary Fig.9: Chromatin-IP using T7-antibody demonstrating interaction of T7-DDB2 with the VEGF, Snail and Zeb1 promoters. Supplementary Fig.10: Transcription factor binding sites in the promoter fragments bound by DDB2 Supplementary Fig.11: Western blot analyses for the DDB2-associated proteins and XPC in DDB2-depleted cells. Supplementary Fig.12: Experimental metastasis assay with polyclonal DDB2 knockdown cells. Supplementary Fig.13: Expression of DDB2 does not inhibit proliferation in SW620 cells.
Supplementary Figure 3 from Immune Response Is an Important Aspect of the Antitumor Effect Produced by a CD40L-Encoding Oncolytic Adenovirus
Authors: Diaconu Iulia , Cerullo Vincenzo , Hirvinen Mari L.M. , Escutenaire Sophie , Ugolini Matteo , Pesonen Saila K. , Bramante Simona , Parviainen Suvi , Kanerva Anna , Loskog Angelica S.I. , Eliopoulos Aristides G. , Pesonen Sari , Hemminki Akseli
Published: March 2023

PDF file - 75K, (A) MB49 cells were infected with 100 viral particles/cell with Ad5/3-CMV-mCD40L and Ad5/3-Luc1 and Annexin-V was assessed 24 hours post-infection by flow cytometry. (B) Replication of Ad5/3-CMV-mCD40L and Ad5/3-Luc1 over time in MB49 cell line. Cell monolayers were infected at doses specified ranging from 101 to 108 viral particles and assays were stopped at different time points (days 2, 3, 4 and 8). Cell viability was measured and expressed overtime. (C) MB49 cells were infected with 100 viral particles and samples were collected at 0, 24, 48 and 72 hours post infection. Quantitative PCR was performed for E4 sequence and values were normalized to mouse beta-actin gene.
Supplementary Methods from TWIST1 Is an ERK1/2 Effector That Promotes Invasion and Regulates MMP-1 Expression in Human Melanoma Cells
Authors: Weiss Michele B. , Abel Ethan V. , Mayberry Melanie M. , Basile Kevin J. , Berger Adam C. , Aplin Andrew E.
Published: March 2023

PDF file - 106K
Supplementary Figure 1 from Immune Response Is an Important Aspect of the Antitumor Effect Produced by a CD40L-Encoding Oncolytic Adenovirus
Authors: Diaconu Iulia , Cerullo Vincenzo , Hirvinen Mari L.M. , Escutenaire Sophie , Ugolini Matteo , Pesonen Saila K. , Bramante Simona , Parviainen Suvi , Kanerva Anna , Loskog Angelica S.I. , Eliopoulos Aristides G. , Pesonen Sari , Hemminki Akseli
Published: March 2023

PDF file - 881K, (A) Oncolytic potency of Ad5/3-hTERT-E1A-hCD40L and (B) Ad5/3-hTERT-E1A on EJ (CD40+) and A549 (CD40-). Cell lines were infected with Ad5/3Luc1, Ad5/3-hTERT-E1A, Ad5/3-hTERT-E1A-hCD40L and Ad5/3-CMV-hCD40L and cell viability was measured by MTS assay The assay was stopped 7 days after infection and the data was plotted to compare efficacy on CD40+ versus CD40- cells; Ad5/3-hTERT-E1A-hCD40L was more effective than the positive control on the former while the opposite was true for the latter. . VP=viral particles. ***, P<0.001 (C) Cell monolayers of EJ and A549 cell lines were infected with 1000VP/cell with Ad5/3-hTERT-E1A-hCD40L and Ad5/3-hTERT-E1A and different concentrations of anti-CD40L antibody were added on the cells. Fourty-eight hours later the assay was stopped by measuring the mitochondrial activity through an MTS determination. Results are presented from triplicates relative to cells treated with virus alone. �g/ml=microgram/milliliter. (D) Cell cycle analysis. Cell monolayers infected with 100VP/cell for 2h were cultured for 48h and fixed in 70% ethanol at 40C overnight. Propidium Iodide staining was performed according to manufacturer instructions and cells were analyzed by FACS-Array. Cell counts of different cell cycle stages are presented relative to total number of cells.
Supplementary Figure 6 from TWIST1 Is an ERK1/2 Effector That Promotes Invasion and Regulates MMP-1 Expression in Human Melanoma Cells
Authors: Weiss Michele B. , Abel Ethan V. , Mayberry Melanie M. , Basile Kevin J. , Berger Adam C. , Aplin Andrew E.
Published: March 2023

PDF file - 3105K, TWIST1 is required for melanoma cell migration towards and invasion through collagen type I
Supplementary Figure 1 from VEGF-C and VEGF-D Blockade Inhibits Inflammatory Skin Carcinogenesis
Authors: Alitalo Annamari K. , Proulx Steven T. , Karaman Sinem , Aebischer David , Martino Stefania , Jost Manuela , Schneider Nicole , Bry Maija , Detmar Michael
Published: March 2023

PDF - 1988K, SVEGFR-3 in serum, tumor growth and malignant transformation and VEGFR-3 ligand effects on epidermal cells.
Supplementary Figure 4 from CIP2A Modulates Cell-Cycle Progression in Human Cancer Cells by Regulating the Stability and Activity of Plk1
Authors: Kim Jae-Sung , Kim Eun Ju , Oh Jeong Su , Park In-Chul , Hwang Sang-Gu
Published: March 2023

PDF file, 43K, CIP2A depletion reduces the kinase activity of Plk1 during mitosis.
Supplementary Figure S5 from mTOR Complex 2 Is Involved in Regulation of Cbl-Dependent c-FLIP Degradation and Sensitivity of TRAIL-Induced Apoptosis
Authors: Zhao Liqun , Yue Ping , Khuri Fadlo R. , Sun Shi-Yong
Published: March 2023

Supplementary Figure S5 PDF file - 172K, siRNA-mediated knockdown of rictor, but not raptor, sensitizes cells to TRAIL-induced apoptosis
Supplementary Figure 3 from Mature Cytotoxic CD56bright/CD16+ Natural Killer Cells Can Infiltrate Lymph Nodes Adjacent to Metastatic Melanoma
Authors: Messaoudene Meriem , Fregni Giulia , Fourmentraux-Neves Emmanuelle , Chanal Johan , Maubec Eve , Mazouz-Dorval Sarra , Couturaud Benoit , Girod Angelique , Sastre-Garau Xavier , Albert Sebastien , Guédon Charles , Deschamps Lydia , Mitilian Delphine , Cremer Isabelle , Jacquelot Nicolas , Rusakiewicz Sylvie , Zitvogel Laurence , Avril Marie-Francoise , Caignard Anne
Published: March 2023

PDF file - 339K, Phenotype of M-LN NK cells in function of the disease stage.
Supplementary Video 9 from Endogenous Two-Photon Fluorescence Imaging Elucidates Metabolic Changes Related to Enhanced Glycolysis and Glutamine Consumption in Precancerous Epithelial Tissues
Authors: Varone Antonio , Xylas Joanna , Quinn Kyle P. , Pouli Dimitra , Sridharan Gautham , McLaughlin-Drubin Margaret E. , Alonzo Carlo , Lee Kyongbum , Münger Karl , Georgakoudi Irene
Published: March 2023

AVI file - 1191KB, Representative endogenous TPEF OPTICAL STACK E6 EETE.
Supplementary Figures 1 - 5 from Casein Kinase 1ϵ Promotes Cell Proliferation by Regulating mRNA Translation
Authors: Shin Sejeong , Wolgamott Laura , Roux Philippe P. , Yoon Sang-Oh
Published: March 2023

PDF file - 186K, Generation of CK1 isoform knockdown cells (S1); Effect of CK1epsilon inhibitor on cell death (S2); CK1epsilon expression in cancer tissue (S3); CK1epsilon interacts with 4E-BP1 (S4); CK1epsilon phosphorylates 4E-BP1 at T41/T50 (S5).
Supplementary Video 10 from Endogenous Two-Photon Fluorescence Imaging Elucidates Metabolic Changes Related to Enhanced Glycolysis and Glutamine Consumption in Precancerous Epithelial Tissues
Authors: Varone Antonio , Xylas Joanna , Quinn Kyle P. , Pouli Dimitra , Sridharan Gautham , McLaughlin-Drubin Margaret E. , Alonzo Carlo , Lee Kyongbum , Münger Karl , Georgakoudi Irene
Published: March 2023

AVI file - 1258KB, Representative 3D RENDERING E6 EETE.
Supplementary Methods, Figure Legends, Video Legends from Endogenous Two-Photon Fluorescence Imaging Elucidates Metabolic Changes Related to Enhanced Glycolysis and Glutamine Consumption in Precancerous Epithelial Tissues
Authors: Varone Antonio , Xylas Joanna , Quinn Kyle P. , Pouli Dimitra , Sridharan Gautham , McLaughlin-Drubin Margaret E. , Alonzo Carlo , Lee Kyongbum , Münger Karl , Georgakoudi Irene
Published: March 2023

PDF file - 147KB
Supplementary Figure 4 from Endogenous Two-Photon Fluorescence Imaging Elucidates Metabolic Changes Related to Enhanced Glycolysis and Glutamine Consumption in Precancerous Epithelial Tissues
Authors: Varone Antonio , Xylas Joanna , Quinn Kyle P. , Pouli Dimitra , Sridharan Gautham , McLaughlin-Drubin Margaret E. , Alonzo Carlo , Lee Kyongbum , Münger Karl , Georgakoudi Irene
Published: March 2023

PDF file - 516KB, TPEF images and quantitative data from cells exposed to KSFM, Low Glu (low glucose), No Glu (no glucose), and Low Oxy (low O2) media.
Supplementary Figure 1 from Endogenous Two-Photon Fluorescence Imaging Elucidates Metabolic Changes Related to Enhanced Glycolysis and Glutamine Consumption in Precancerous Epithelial Tissues
Authors: Varone Antonio , Xylas Joanna , Quinn Kyle P. , Pouli Dimitra , Sridharan Gautham , McLaughlin-Drubin Margaret E. , Alonzo Carlo , Lee Kyongbum , Münger Karl , Georgakoudi Irene
Published: March 2023

PDF file - 287KB, Representative autofluorescence images and 3D renderings for each type of EETE.
Supplementary Table 1 from TGF-β Mediates Homing of Bone Marrow–Derived Human Mesenchymal Stem Cells to Glioma Stem Cells
Authors: Shinojima Naoki , Hossain Anwar , Takezaki Tatsuya , Fueyo Juan , Gumin Joy , Gao Feng , Nwajei Felix , Marini Frank C. , Andreeff Michael , Kuratsu Jun-Ichi , Lang Frederick F.
Published: March 2023

PDF file - 57K, Primer sequences for STR markers.
Supplementary Table 1 from Natural Human Plasmacytoid Dendritic Cells Induce Antigen-Specific T-Cell Responses in Melanoma Patients
Authors: Tel Jurjen , Aarntzen Erik H.J.G. , Baba Tetsuro , Schreibelt Gerty , Schulte Barbara M. , Benitez-Ribas Daniel , Boerman Otto C. , Croockewit Sandra , Oyen Wim J.G. , van Rossum Michelle , Winkels Gregor , Coulie Pierre G. , Punt Cornelis J.A. , Figdor Carl G. , de Vries I. Jolanda M.
Published: March 2023

Supplementary Table 1 PDF file - 29K, Induration (mm) of the different injection sites in the DTH skin test
Supplementary Materials and Methods from FOXC2 Expression Links Epithelial–Mesenchymal Transition and Stem Cell Properties in Breast Cancer
Authors: Hollier Brett G. , Tinnirello Agata A. , Werden Steven J. , Evans Kurt W. , Taube Joseph H. , Sarkar Tapasree Roy , Sphyris Nathalie , Shariati Maryam , Kumar Sreedevi V. , Battula Venkata L. , Herschkowitz Jason I. , Guerra Rudy , Chang Jeffrey T. , Miura Naoyuki , Rosen Jeffrey M. , Mani Sendurai A.
Published: March 2023

Supplementary Materials and Methods PDF File - 113K, Supplemental materials and methods section
Supplementary Figure 3 from FOXC2 Expression Links Epithelial–Mesenchymal Transition and Stem Cell Properties in Breast Cancer
Authors: Hollier Brett G. , Tinnirello Agata A. , Werden Steven J. , Evans Kurt W. , Taube Joseph H. , Sarkar Tapasree Roy , Sphyris Nathalie , Shariati Maryam , Kumar Sreedevi V. , Battula Venkata L. , Herschkowitz Jason I. , Guerra Rudy , Chang Jeffrey T. , Miura Naoyuki , Rosen Jeffrey M. , Mani Sendurai A.
Published: March 2023

Supplementary Figure 3 PDF File - 326K, Attenuation of FOXC2 expression leads to reduced levels of PDGFR- �. (a) Immunofluorescene staining for PDGFR-� (red) detected with Alexa Fluor 548 anti-mouse secondary antibody in HMLE, HMLE-Snail-shCntrl and HMLE-Snail-shFOXC2 cells. Nuclei were counterstained with DAPI and overlayed images are shown.Scale bar indicates 100 �m. (b) FACS analysis of PDGFR-� cell surface expression using anti- PDGFR-�-PE antibody in cells described in (a). The histogram represents the intensity of PE signal in the FL2 detector on the x-axis
Supplementary Figure 1 from TGF-β Mediates Homing of Bone Marrow–Derived Human Mesenchymal Stem Cells to Glioma Stem Cells
Authors: Shinojima Naoki , Hossain Anwar , Takezaki Tatsuya , Fueyo Juan , Gumin Joy , Gao Feng , Nwajei Felix , Marini Frank C. , Andreeff Michael , Kuratsu Jun-Ichi , Lang Frederick F.
Published: March 2023

PDF file - 1222K, The migration of BM-hMSCs toward increasing concentrations of TGF-β1.
Supplementary Figure 4 from Myeloid-Specific Expression of Ron Receptor Kinase Promotes Prostate Tumor Growth
Authors: Gurusamy Devikala , Gray Jerilyn K. , Pathrose Peterson , Kulkarni Rishikesh M. , Finkleman Fred D. , Waltz Susan E.
Published: March 2023

PDF file - 101K, FACs analysis of bone marrow derived cells from TK+/+ and TK-/- mice. For Review and Publication Both.
Supplementary Table S2 from MYC Regulation of CHK1 and CHK2 Promotes Radioresistance in a Stem Cell-like Population of Nasopharyngeal Carcinoma Cells
Authors: Wang Wen-Jun , Wu Si-Pei , Liu Jia-Bin , Shi Yong-Sheng , Huang Xue , Zhang Qian-Bing , Yao Kai-Tai
Published: March 2023

XLS file - 81K,Binding sites (c-MYCBSs) within the 2000bp promoter upstream of the CHK1 and CHK2 genes
Supplementary Figure 2 from MYC Regulation of CHK1 and CHK2 Promotes Radioresistance in a Stem Cell-like Population of Nasopharyngeal Carcinoma Cells
Authors: Wang Wen-Jun , Wu Si-Pei , Liu Jia-Bin , Shi Yong-Sheng , Huang Xue , Zhang Qian-Bing , Yao Kai-Tai
Published: March 2023

PDF file - 2674K, A, Western blot analysis of c-MYC, CHK1, and CHK2 in vector control and c-MYC+shCHK1/shCHK2 infected PKH26- NPC CNE2 cells. B. EdU proliferation assay of vector control, c-MYC, and c-MYC+shCHK1/CHK2 infected irradiated (8 Gy) PKH26- NPC CNE2 cells. Quantification of the percentages of cells with comet tails following irradiation at different doses. (Data represent the mean�standard deviation (SD); N = 3; *P=0.000; **P=0.064, with a 20 msec exposure time for image acquisition). C. Alkaline comet assay of vector control, c-MYC, and c-MYC+shCHK1/CHK2 infected irradiated (8 Gy) PKH26+NPC CNE2 cells. Quantification of the percentages of cells with comet tails following irradiation at different doses (Data represent the mean�standard deviation (SD); N = 3; *P=0.000; **P=0.102)
Supplementary Figure 2 from mTOR Inhibitors Block Kaposi Sarcoma Growth by Inhibiting Essential Autocrine Growth Factors and Tumor Angiogenesis
Authors: Roy Debasmita , Sin Sang-Hoon , Lucas Amy , Venkataramanan Raman , Wang Ling , Eason Anthony , Chavakula Veenadhari , Hilton Isaac B. , Tamburro Kristen M. , Damania Blossom , Dittmer Dirk P.
Published: March 2023

PDF file - 84K, Suppl. Figure 2: Apoptosis induction of PEL cells by combination of rapamycin and doxorubicin in culture
Supplementary Figure 1 from MYC Regulation of CHK1 and CHK2 Promotes Radioresistance in a Stem Cell-like Population of Nasopharyngeal Carcinoma Cells
Authors: Wang Wen-Jun , Wu Si-Pei , Liu Jia-Bin , Shi Yong-Sheng , Huang Xue , Zhang Qian-Bing , Yao Kai-Tai
Published: March 2023

PDF file - 2945K, A, Flow cytometry of CD44 expression in PHK26 + cells. Data represent the mean�standard deviation (SD); n = 3. B, The delineation of CNE1 and CNE2 cells after labeling with PKH26 and treated with PI in Flow cytometry. C, RT-PCR validation of c-MYC, CHK1, CHK2, and ATM RNA levels in CNE2 cells. D, Western blot analysis of c-MYC, pCHK1, and pCHK2 markers in CNE2 cells. GAPDH served as a loading control
Supplementary Table 2 from Automated Tracking of Nanoparticle-labeled Melanoma Cells Improves the Predictive Power of a Brain Metastasis Model
Authors: Sundstrøm Terje , Daphu Inderjit , Wendelbo Ingvild , Hodneland Erlend , Lundervold Arvid , Immervoll Heike , Skaftnesmo Kai Ove , Babic Michal , Jendelova Pavla , Sykova Eva , Lund-Johansen Morten , Bjerkvig Rolf , Thorsen Frits
Published: March 2023

PDF file - 94K, CellProfiler pipeline for spheroid growth analysis
Supplementary Table 1 from Identification of an Aurora Kinase Inhibitor Specific for the Aurora B Isoform
Authors: Xie Hua , Lee Mee-Hyun , Zhu Feng , Reddy Kanamata , Peng Cong , Li Yan , Lim Do Young , Joon Kim Dong , Li Xiang , Kang Soouk , Li Haitao , Ma Weiya , Lubet Ronald A. , Ding Jian , Bode Ann M. , Dong Zigang
Published: March 2023

PDF file - 73K, Kinase profiling results of HOI-07 performed by Millipore. The concentration of HOI-07 used for profiling was 5 muM
Supplementary Figure 7 from Therapeutic PD-1 Pathway Blockade Augments with Other Modalities of Immunotherapy T-Cell Function to Prevent Immune Decline in Ovarian Cancer
Authors: Duraiswamy Jaikumar , Freeman Gordon J. , Coukos George
Published: March 2023

PDF file, 120K, FVAX in combination with aPD-L1 and a4-1BB treatment promotes lymphocyte infiltration into the tumor.
Supplementary Figure Legends from Cholesterol Loading and Ultrastable Protein Interactions Determine the Level of Tumor Marker Required for Optimal Isolation of Cancer Cells
Authors: Jain Jayati , Veggiani Gianluca , Howarth Mark
Published: March 2023

Supplementary Figure Legends PDF file - 73K, Legend for Supplementary Figures S1-S9
Supplementary Figure 3 from FGF-2 Disrupts Mitotic Stability in Prostate Cancer through the Intracellular Trafficking Protein CEP57
Authors: Cuevas Rolando , Korzeniewski Nina , Tolstov Yanis , Hohenfellner Markus , Duensing Stefan
Published: March 2023

PDF file - 374K, Supernumerary centrioles co-localize with CAP350.
Supplementary Figures 1 - 5 from Neuregulin Autocrine Signaling Promotes Self-Renewal of Breast Tumor-Initiating Cells by Triggering HER2/HER3 Activation
Authors: Lee Cleo Yi-Fang , Lin Yuan , Bratman Scott V. , Feng Weiguo , Kuo Angera H. , Scheeren Ferenc A. , Engreitz Jesse M. , Varma Sushama , West Robert B. , Diehn Maximilian
Published: March 2023

PDF file - 581K, Breast TICs are enriched in the CD24HiCD49fHi subpopulation (S1); Expression of HER receptors and ligands in breast cancer cell lines (S2); HER2 inhibition reduces the EpCAM- TIC-like subpopulation of SUM149 cells (S3); Breast TICs are enriched in the EPCAM+CD49f+ subpopulation of a triple-negative patient-derived xenograft breast tumor BCA70 (S4); Dual inhibition of HER2 and EGFR targets breast TICs in patient-derived xenograft BCA71 (S5).
Supplementary Figure 4 from Local and Systemic Protumorigenic Effects of Cancer-Associated Fibroblast-Derived GDF15
Authors: Bruzzese Francesca , Hägglöf Christina , Leone Alessandra , Sjöberg Elin , Roca Maria Serena , Kiflemariam Sara , Sjöblom Tobias , Hammarsten Peter , Egevad Lars , Bergh Anders , Östman Arne , Budillon Alfredo , Augsten Martin
Published: March 2023

PDF file - 66KB, Recombinant GDF15/MIC-1 stimulates prostate cancer cell growth and invasion.
Supplementary Figure 3 from Local and Systemic Protumorigenic Effects of Cancer-Associated Fibroblast-Derived GDF15
Authors: Bruzzese Francesca , Hägglöf Christina , Leone Alessandra , Sjöberg Elin , Roca Maria Serena , Kiflemariam Sara , Sjöblom Tobias , Hammarsten Peter , Egevad Lars , Bergh Anders , Östman Arne , Budillon Alfredo , Augsten Martin
Published: March 2023

PDF file - 117KB, Prostate cancer cells, NIH-GDF15 fibroblasts and CAFs secrete human GDF15/MIC-1.
Supplementary Methods from A Preclinical Assay for Chemosensitivity in Multiple Myeloma
Authors: Khin Zayar P. , Ribeiro Maria L.C. , Jacobson Timothy , Hazlehurst Lori , Perez Lia , Baz Rachid , Shain Kenneth , Silva Ariosto S.
Published: March 2023

PDF file - 174K, Description of the processing of bone marrow aspirates, as well as the source code for fitting of cell viability measurements into dose/response surfaces.
Supplementary Figure 1 from Metalloprotease-Mediated Tumor Cell Shedding of B7-H6, the Ligand of the Natural Killer Cell–Activating Receptor NKp30
Authors: Schlecker Eva , Fiegler Nathalie , Arnold Annette , Altevogt Peter , Rose-John Stefan , Moldenhauer Gerhard , Sucker Antje , Paschen Annette , von Strandmann Elke Pogge , Textor Sonja , Cerwenka Adelheid
Published: March 2023

PDF file - 127KB, Tumor cell supernatants modulate NKp30 expression regardless of the presence or absence of soluble B7-H6.
Supplementary Table S5 from Amplification of FRS2 and Activation of FGFR/FRS2 Signaling Pathway in High-Grade Liposarcoma
Authors: Zhang Keqiang , Chu Kevin , Wu Xiwei , Gao Hanlin , Wang Jinhui , Yuan Yate-Ching , Loera Sofia , Ho Kimberley , Wang Yafan , Chow Warren , Un Frank , Chu Peiguo , Yen Yun
Published: March 2023

Supplementary Table S5 PDF file 57K, Relative gene copy number determined by qPCR analysis (ratio to adjacent normal tissue) of selected eight genes located on chromosome 12q13-15 of individual DDLS
Supplementary Table S4 from Amplification of FRS2 and Activation of FGFR/FRS2 Signaling Pathway in High-Grade Liposarcoma
Authors: Zhang Keqiang , Chu Kevin , Wu Xiwei , Gao Hanlin , Wang Jinhui , Yuan Yate-Ching , Loera Sofia , Ho Kimberley , Wang Yafan , Chow Warren , Un Frank , Chu Peiguo , Yen Yun
Published: March 2023

Supplementary Table S4 PDF file 59K, Relative gene copy number determined by qPCR analysis (ratio to adjacent normal tissue) of selected eight genes located on chromosome 12q13-15 of individual UHGPS
Supplementary Figure 5 from Taccalonolide Binding to Tubulin Imparts Microtubule Stability and Potent In Vivo Activity
Authors: Risinger A.L. , Li J. , Bennett M.J. , Rohena C.C. , Peng J. , Schriemer D.C. , Mooberry S.L.
Published: March 2023

PDF file - 64K, The effect of AJ on the mass of the beta213-230 peptic peptide.
Supplementary Table Legend from Amplification of FRS2 and Activation of FGFR/FRS2 Signaling Pathway in High-Grade Liposarcoma
Authors: Zhang Keqiang , Chu Kevin , Wu Xiwei , Gao Hanlin , Wang Jinhui , Yuan Yate-Ching , Loera Sofia , Ho Kimberley , Wang Yafan , Chow Warren , Un Frank , Chu Peiguo , Yen Yun
Published: March 2023

Supplementary Table Legend PDF file 58K, Legend for Supplementary Tables S1-S5
Supplementary Figures 1 - 8 from Dormant Cancer Cells Contribute to Residual Disease in a Model of Reversible Pancreatic Cancer
Authors: Lin Wan-chi , Rajbhandari Nirakar , Liu Chengbao , Sakamoto Kazuhito , Zhang Qian , Triplett Aleata A. , Batra Surinder K. , Opavsky Rene , Felsher Dean W. , DiMaio Dominick J. , Hollingsworth Michael A. , Morris John P. , Hebrok Matthias , Witkiewicz Agnieszka K. , Brody Jonathan R. , Rui Hallgeir , Wagner Kay-Uwe
Published: March 2023

PDF file - 719K, Elevated c-MYC expression in human pancreatic cancer cell lines (S1); c-Myc is highly upregulated in a mouse model for pancreatic cancer (S2); Levels of c-Myc (exogenous and endogenous) in ductal and poorly differentiated pancreatic adenocarcinomas that were induced through upregulation of this oncogene in comparison to pancreatic tumors from Pdx1-Cre LSL-KrasG12D animals that carry two wildtype or one mutant allele of p53 (S3); Expression of Muc1, E-Cadherin, Pdx1, and Sox9 in the normal pancreas as well as ductal carcinomas and poorly differentiated carcinomas of transgenic mice expressing exogenous c-Myc (S4); Elevated levels of exogenous c-Myc induces expression of Bax and active Caspase-3 (S5); Ablation of c-Myc expression leads to reduced proliferation, increased expression of p53 as well as autophagy-related protein LC3 but a reduction in the levels of active Caspase-3 (S6); Downregulation of active Caspase-3 and upregulation of LC3 in pancreatic cancers that lack Cdkn2a (S7); Residual cancer cells do not express c-Myc, lack nuclear staining of Ki67 and are TUNEL negative (S8).
Supplementary Tables 1 - 4 from 14-3-3ζ Orchestrates Mammary Tumor Onset and Progression via miR-221–Mediated Cell Proliferation
Authors: Rehman Sumaiyah K. , Li Shau-Hsuan , Wyszomierski Shannon L. , Wang Qingfei , Li Ping , Sahin Ozgur , Xiao Yi , Zhang Siyuan , Xiong Yan , Yang Jun , Wang Hai , Guo Hua , Zhang Jitao D. , Medina Daniel , Muller William J. , Yu Dihua
Published: March 2023

PDF file - 297K, Tumor incidence and latency in MMTV-HA-14-3-3zeta transgenic and wild type mice (S1); Mammary tumor histology and latency in female MMTV-HA-14-3-3zeta transgenic mice (S2); TMA Analysis (S3); Confusion matrix of SVM (S4).
Supplementary Methods from G-protein Inactivator RGS6 Mediates Myocardial Cell Apoptosis and Cardiomyopathy Caused By Doxorubicin
Authors: Yang Jianqi , Maity Biswanath , Huang Jie , Gao Zhan , Stewart Adele , Weiss Robert M. , Anderson Mark E. , Fisher Rory A.
Published: March 2023

PDF file - 34K
Supplementary Information from ATIP3, a Novel Prognostic Marker of Breast Cancer Patient Survival, Limits Cancer Cell Migration and Slows Metastatic Progression by Regulating Microtubule Dynamics
Authors: Molina Angie , Velot Lauriane , Ghouinem Lydia , Abdelkarim Mohamed , Bouchet Benjamin Pierre , Luissint Anny-Claude , Bouhlel Imène , Morel Marina , Sapharikas Elène , Di Tommaso Anne , Honoré Stéphane , Braguer Diane , Gruel Nadège , Vincent-Salomon Anne , Delattre Olivier , Sigal-Zafrani Brigitte , André Fabrice , Terris Benoit , Akhmanova Anna , Di Benedetto Mélanie , Nahmias Clara , Rodrigues-Ferreira Sylvie
Published: March 2023

Supplementary Information PDF file - 115K, Supplemental materials and methods, legends to Movies and supplemental references
Supplementary Table 2 from MAPK Kinase 3 Is a Tumor Suppressor with Reduced Copy Number in Breast Cancer
Authors: MacNeil Adam J. , Jiao Shun-Chang , McEachern Lori A. , Yang Yong Jun , Dennis Amanda , Yu Haiming , Xu Zhaolin , Marshall Jean S. , Lin Tong-Jun
Published: March 2023

XLSX file - 176K, Supplementary Table S2. Gene expression profile for MKK3dn and MKK3ca cells (vs. WT / MDA-MB-468) using the human breast cancer array (Qiagen, PAHS-131A ), summary of n = 3 experiments.
Supplementary Table 2 from CUL3 and NRF2 Mutations Confer an NRF2 Activation Phenotype in a Sporadic Form of Papillary Renal Cell Carcinoma
Authors: Ooi Aikseng , Dykema Karl , Ansari Asif , Petillo David , Snider John , Kahnoski Richard , Anema John , Craig David , Carpten John , Teh Bin-Tean , Furge Kyle A.
Published: March 2023

XLSX file - 5963K, Genes that are significantly deregulated (fdr < 0.1) in tumor tissue from Case-337 in relative to pooled normal kidney tissues
Supplementary Figure 3 from Mislocalization of the Cell Polarity Protein Scribble Promotes Mammary Tumorigenesis and Is Associated with Basal Breast Cancer
Authors: Feigin Michael E. , Akshinthala S. Dipikaa , Araki Kiyomi , Rosenberg Avi Z. , Muthuswamy Lakshmi B. , Martin Bernard , Lehmann Brian D. , Berman Hal K. , Pietenpol Jennifer A. , Cardiff Robert D. , Muthuswamy Senthil K.
Published: March 2023

PDF file - 204K, Characterization of hSCRIBP305L tumors.
Supplementary Figure 3 from Nitroreductase, a Near-Infrared Reporter Platform for In Vivo Time-Domain Optical Imaging of Metastatic Cancer
Authors: McCormack Emmet , Silden Elisabeth , West Richard M. , Pavlin Tina , Micklem David R. , Lorens James B. , Haug Bengt Erik , Cooper Michael E. , Gjertsen Bjørn Tore
Published: March 2023

PDF file - 314K, In vivo characterization of NTR/CytoCy5S fluorescence and fluorescence lifetime distributions in NB4NTR+GFP+ subcutaneous tumors, NCI-H460NTR+Luc+GFP+ orthotopic xenografts and gastrointestinal tract.
Supplementary Figure Legends from NADPH Oxidase NOX4 Supports Renal Tumorigenesis by Promoting the Expression and Nuclear Accumulation of HIF2α
Authors: Gregg Jennifer L. , Turner Robert M. , Chang Guimin , Joshi Disha , Zhan Ye , Chen Li , Maranchie Jodi K.
Published: March 2023

PDF file - 42K
Supplementary Figure Legend from Low PIP4K2B Expression in Human Breast Tumors Correlates with Reduced Patient Survival: A Role for PIP4K2B in the Regulation of E-Cadherin Expression
Authors: Keune Willem-Jan , Sims Andrew H. , Jones David R. , Bultsma Yvette , Lynch James T. , Jirström Karin , Landberg Goran , Divecha Nullin
Published: March 2023

PDF file - 77K
Supplementary Figure 6 from Low PIP4K2B Expression in Human Breast Tumors Correlates with Reduced Patient Survival: A Role for PIP4K2B in the Regulation of E-Cadherin Expression
Authors: Keune Willem-Jan , Sims Andrew H. , Jones David R. , Bultsma Yvette , Lynch James T. , Jirström Karin , Landberg Goran , Divecha Nullin
Published: March 2023

PDF file - 46K, A. Lysates from MCF10A cells after 2 and 4 days of growth were analysed by western blotting using the antibodies shown. B. Lysates from cells treated as controls or with MG132 were analysed by western blotting with an anti-ubiquitin antibody to demonstrate that MG132 increases polyubiquitination of proteins.
Supplementary Figure 4 from NADPH Oxidase NOX4 Supports Renal Tumorigenesis by Promoting the Expression and Nuclear Accumulation of HIF2α
Authors: Gregg Jennifer L. , Turner Robert M. , Chang Guimin , Joshi Disha , Zhan Ye , Chen Li , Maranchie Jodi K.
Published: March 2023

PDF file - 183K, Supplemental Figure 4. Cytotoxicity was measured by CellTiter-Blue (Promega, Madison, WI). 786-0 NS cells were plated at 1 x 104 cells per well in 96-well plates. After 24 hours, dithiothreitol was added as indicated in 5 replicate wells. 20 �l of the CellTiter-Blue reagent was added to each well and viability quantitated by spectrofluorometer (Spectra Max Plus384, Molecular Devices) and expressed as percentage of viability of media-only controls. Error bars indicate +/- S.E. mean.
Supplementary Figures 1-6 from Chromosome Instability Modulated by BMI1–AURKA Signaling Drives Progression in Head and Neck Cancer
Authors: Chou Chun-Hung , Yang Neng-Kai , Liu Ting-Yun , Tai Shyh-Kuan , Hsu Dennis Shin-Shian , Chen Ya-Wei , Chen Yann-Jang , Chang Cheng-Chi , Tzeng Cheng-Hwai , Yang Muh-Hwa
Published: March 2023

PDF file -810KB, Twist1 upregulates Bmi1 and aurora kinase A expression, and co-amplification of BMI1 and AURKA in CD44+ HNSCC cells (S1); Akt pathway and let-7i repression are two independent mechanisms induced by Bmi1 to regulate aurora kinase A expression (S2); Suppression of Bmi1 or aurora kinase A reduces centrosomal amplification, aneuploidy, reduces p53 serine 315 phosphorylation and stabilizes p53 in OECM-1 cells (S3); Knockdown of aurora kinase A represses EMT, and overexpression of aurora kinase A is sufficient to induce EMT (S4); The influence of aurora kinase A on the expression of different EMT regulators (S5); Aurora kinase A increases GSK-3� phosphorylation and interacts with GSK-3� in HNSCC cell lines (S6)
Supplementary Figure Legend from Pirfenidone Inhibits Pancreatic Cancer Desmoplasia by Regulating Stellate Cells
Authors: Kozono Shingo , Ohuchida Kenoki , Eguchi Daiki , Ikenaga Naoki , Fujiwara Kenji , Cui Lin , Mizumoto Kazuhiro , Tanaka Masao
Published: March 2023

PDF file - 82K
Supplementary Figure Legend from Trask Loss Enhances Tumorigenic Growth by Liberating Integrin Signaling and Growth Factor Receptor Cross-Talk in Unanchored Cells
Authors: Spassov Danislav S. , Wong Ching Hang , Wong Sunny Y. , Reiter Jeremy F. , Moasser Mark M.
Published: March 2023

PDF file - 63K
Supplementary Figure 3 from Trask Loss Enhances Tumorigenic Growth by Liberating Integrin Signaling and Growth Factor Receptor Cross-Talk in Unanchored Cells
Authors: Spassov Danislav S. , Wong Ching Hang , Wong Sunny Y. , Reiter Jeremy F. , Moasser Mark M.
Published: March 2023

PDF file - 485K, Neoplasia in SmoM2-induced mice epidermis
Supplementary Figure Legends from Endocrine Fibroblast Growth Factor FGF19 Promotes Prostate Cancer Progression
Authors: Feng Shu , Dakhova Olga , Creighton Chad J. , Ittmann Michael
Published: March 2023

PDF file - 53KB
Supplementary Figures 1 - 6 from 3′-UTR Poly(T/U) Tract Deletions and Altered Expression of EWSR1 Are a Hallmark of Mismatch Repair–Deficient Cancers
Authors: Kishore Shivendra , Piscuoglio Salvatore , Kovac Michal B. , Gylling Annette , Wenzel Friedel , Trapani Francesca , Altermatt Hans Joerg , Mele Valentina , Marra Giancarlo , Peltomäki Päivi , Terracciano Luigi , Zavolan Mihaela , Heinimann Karl
Published: March 2023

PDF file - 300K, Supplementary Figure 1: Immunohistochemical profiling of DNA mismatch repair proteins in the extra-osseous Ewing Sarcoma. Supplementary Figure 2: Fluorescence in situ hybridization (FISH) analysis of the MHS6-related extra-osseous Ewing sarcoma. Supplementary Figure 3: Frequency distribution of EWS16T repeat alterations. Supplementary Figure 4: Schematic representation of EWSR1 3'UTR Supplementary Figure 5: Protein pull down assay representation. Supplementary Figure 6: Luciferase assay in different EWS16T tract variants.
Supplementary Table 2 from Human Rhomboid Family-1 Suppresses Oxygen-Independent Degradation of Hypoxia-Inducible Factor-1α in Breast Cancer
Authors: Zhou Zhuan , Liu Fangfang , Zhang Zhi-Song , Shu Feifei , Zheng Yangyang , Fu Li , Li Lu-Yuan
Published: March 2023

PDF file - 63KB, Amino acid sequences of peptides resembling potential phosphorylation sites on the RHBDF1 protein.
Supplementary Table 1 from Inhibition of Protein Kinase CK2 Reduces Cyp24a1 Expression and Enhances 1,25-Dihydroxyvitamin D3 Antitumor Activity in Human Prostate Cancer Cells
Authors: Luo Wei , Yu Wei-Dong , Ma Yingyu , Chernov Mikhail , Trump Donald L. , Johnson Candace S.
Published: March 2023

PDF file - 56K, Prostate tumor and matching normal
Supplementary Figures 1 - 6 from Human Rhomboid Family-1 Suppresses Oxygen-Independent Degradation of Hypoxia-Inducible Factor-1α in Breast Cancer
Authors: Zhou Zhuan , Liu Fangfang , Zhang Zhi-Song , Shu Feifei , Zheng Yangyang , Fu Li , Li Lu-Yuan
Published: March 2023

PDF file - 440KB, Immunohistochemical analyses of RHBDF1 and HIF1a expression in breast cancer clinical specimens (S1). RHBDF1 action on HIF1a stability does not involve HIF1a mRNA levels (S2). Prediction of transmembrane topology and phosphorylation sites of RHBDF1 (S3). Effects of peptide VR56 on the expression of HIF1a targeted genes and breast cancer cell viability (S4). Inhibitory effect of RHBDF1 gene silencing in MCF7 cells on HIF1a stability (S5). Western blotting analysis showing involvement of RACK1 and RHBDF1 in HIF1a stabilization in breast cancer cell MCF7 or T47D (S6).
Supplementary Methods, Figures Legends 1-7 from De Novo Design of a Tumor-Penetrating Peptide
Authors: Alberici Luca , Roth Lise , Sugahara Kazuki N. , Agemy Lilach , Kotamraju Venkata R. , Teesalu Tambet , Bordignon Claudio , Traversari Catia , Rizzardi Gian-Paolo , Ruoslahti Erkki
Published: March 2023

PDF file - 129K
Supplementary Tables 1 - 7 from A Meta-analysis of Lung Cancer Gene Expression Identifies PTK7 as a Survival Gene in Lung Adenocarcinoma
Authors: Chen Ron , Khatri Purvesh , Mazur Pawel K. , Polin Melanie , Zheng Yanyan , Vaka Dedeepya , Hoang Chuong D. , Shrager Joseph , Xu Yue , Vicent Silvestre , Butte Atul J. , Sweet-Cordero E. Alejandro
Published: March 2023

XLSX file - 40KB, Data sets used in discovery meta-analysis (S1). Data sets used in validation meta-analysis (S2). Gene-level results in validation meta-analysis (S3). Data sets used in NSCLC histological subtype meta-analysis (S4). Gene-level results in NSCLC histological subtype (ADC vs SCC) meta-analysis (S5). Tissue microarray specimen annotations and PTK7 staining results (S6). Cell line annotations (S7).
Data Supplement from Neutralizing Murine TGFβR2 Promotes a Differentiated Tumor Cell Phenotype and Inhibits Pancreatic Cancer Metastasis
Authors: Ostapoff Katherine T. , Cenik Bercin Kutluk , Wang Miao , Ye Risheng , Xu Xiaohong , Nugent Desiree , Hagopian Moriah M. , Topalovski Mary , Rivera Lee B. , Carroll Kyla D. , Brekken Rolf A.
Published: March 2023

Supplemental Materials and Methods. Description of additional methods and procedures used in the study.
Supplementary Figure 6 from shRNA Kinome Screen Identifies TBK1 as a Therapeutic Target for HER2+ Breast Cancer
Authors: Deng Tao , Liu Jeff C. , Chung Philip E.D. , Uehling David , Aman Ahmed , Joseph Babu , Ketela Troy , Jiang Zhe , Schachter Nathan F. , Rottapel Robert , Egan Sean E. , Al-awar Rima , Moffat Jason , Zacksenhaus Eldad
Published: March 2023

PDF file - 66KB, Supplementary Figure S6 shows IC50 values of indicated drugs on Her2/Neu-monolayer, SKBR3, HCC1954 or JIMT1 cells.
Supplementary Figure 1 from shRNA Kinome Screen Identifies TBK1 as a Therapeutic Target for HER2+ Breast Cancer
Authors: Deng Tao , Liu Jeff C. , Chung Philip E.D. , Uehling David , Aman Ahmed , Joseph Babu , Ketela Troy , Jiang Zhe , Schachter Nathan F. , Rottapel Robert , Egan Sean E. , Al-awar Rima , Moffat Jason , Zacksenhaus Eldad
Published: March 2023

PDF file - 51KB, Supplementary Figure S1 summarizes the primary screens including number of shRNAs/kinases tested, and number of hits on Her2+ tumorspheres only, tumorsphere plus monolayer or monolayer only.
Supplementary Figure 1 from Increased Dietary Vitamin D Suppresses MAPK Signaling, Colitis, and Colon Cancer
Authors: Meeker Stacey , Seamons Audrey , Paik Jisun , Treuting Piper M. , Brabb Thea , Grady William M. , Maggio-Price Lillian
Published: March 2023

PDF file - 99K, Study design.
Supplementary Figure S2 from LIMD2 Is a Small LIM-Only Protein Overexpressed in Metastatic Lesions That Regulates Cell Motility and Tumor Progression by Directly Binding to and Activating the Integrin-Linked Kinase
Authors: Peng Hongzhuang , Talebzadeh-Farrooji Mehdi , Osborne Michael J. , Prokop Jeremy W. , McDonald Paul C. , Karar Jayashree , Hou Zhaoyuan , He Mei , Kebebew Electron , Orntoft Torben , Herlyn Meenhard , Caton Andrew J. , Fredericks William , Malkowicz Bruce , Paterno Christopher S. , Carolin Alexandra S. , Speicher David W. , Skordalakes Emmanuel , Huang Qihong , Dedhar Shoukat , Borden Katherine L.B. , Rauscher Frank J.
Published: March 2023

Total mRNA was extracted from cancer cell lines using RNeasy Mini Kit (Qiagen).
Supplementary Methods from A Novel Class of Anticancer Compounds Targets the Actin Cytoskeleton in Tumor Cells
Authors: Stehn Justine R. , Haass Nikolas K. , Bonello Teresa , Desouza Melissa , Kottyan Gregg , Treutlein Herbert , Zeng Jun , Nascimento Paula R.B.B. , Sequeira Vanessa B. , Butler Tanya L. , Allanson Munif , Fath Thomas , Hill Timothy A. , McCluskey Adam , Schevzov Galina , Palmer Stephen J. , Hardeman Edna C. , Winlaw David , Reeve Vivienne E. , Dixon Ian , Weninger Wolfgang , Cripe Timothy P. , Gunning Peter W.
Published: March 2023

PDF file - 129K, Supplementary Experimental Methods: Animal studies: Detailed methods outlining the in vivo TR100 animal studies. Tropomyosin compound modeling: Detailed method outlining the in silico modeling of Tm5NM1.
Supplementary Table 1 from MYCN-Dependent Expression of Sulfatase-2 Regulates Neuroblastoma Cell Survival
Authors: Solari Valeria , Borriello Lucia , Turcatel Gianluca , Shimada Hiroyuki , Sposto Richard , Fernandez G. Esteban , Asgharzadeh Shahab , Yates Edwin A. , Turnbull Jeremy E. , DeClerck Yves A.
Published: March 2023

Sequences of primers used for RT-PCR.
Supplementary Figure 1 from Novel Mechanism of MDA-7/IL-24 Cancer-Specific Apoptosis through SARI Induction
Authors: Dash Rupesh , Bhoopathi Praveen , Das Swadesh K. , Sarkar Siddik , Emdad Luni , Dasgupta Santanu , Sarkar Devanand , Fisher Paul B.
Published: March 2023

PDF file - 174K, S1. Expression of IL-20R1, IL-20R2 and IL-22R receptors in A549, DU-145 and HO-1 cells.
Supplementary Figure 1 from Extracellular Vesicles Modulate the Glioblastoma Microenvironment via a Tumor Suppression Signaling Network Directed by miR-1
Authors: Bronisz Agnieszka , Wang Yan , Nowicki Michal O. , Peruzzi Pierpaolo , Ansari Khairul I. , Ogawa Daisuke , Balaj Leonora , De Rienzo Gianluca , Mineo Marco , Nakano Ichiro , Ostrowski Michael C. , Hochberg Fred , Weissleder Ralph , Lawler Sean E. , Chiocca E. Antonio , Godlewski Jakub
Published: March 2023

PDF file - 154K, FIGURE S1 related to FIGURE2. Effect of miR-1 overexpression on GBM cells in vivo.
Data Supplement from AR-Regulated TWEAK-FN14 Pathway Promotes Prostate Cancer Bone Metastasis
Authors: Yin JuanJuan , Liu Yen-Nien , Tillman Heather , Barrett Ben , Hewitt Stephen , Ylaya Kris , Fang Lei , Lake Ross , Corey Eva , Morrissey Colm , Vessella Robert , Kelly Kathleen
Published: March 2023

Supplemental Figure 1.(A) In vitro growth assay for DU145/RasB1 and DU145/RasB1Fn14shRNA cell lines. (B) Average body weight of mice bearing DU145/RasB1 tumors (n= 9mice) or DU145/RasB1Fn14shRNA tumors over time after tumor cell inoculation (shRNA1, n=10 mice; shRNA2, n=10 mice). * p<0.05 vs EV. (C) Average BLI signal in brain metastasis in mice bearing DU145/RasB1/EV, or DU145/RasB1Fn14shRNA tumor at week 4. *** p<0.001 vs control (D) In vitro growth rate of PC3/EV cells and PC3/Fn14shRNA cell lines. (E) Average BLI signal in bone metastasis per mouse in mice bearing PC3/EV tumors or PC3/Fn14shRNA tumors at week 4. Numbers represent mice with bone metastasis over total mice tested. *p<0.05, **p<0.01 vs EV. (F) Survival curve of mice bearing PC3/EV or two PC3/Fn14shRNA cell lines.**p<0.01 vs EV.
Supplementary Figures 1 - 7 from Tumor-Derived GM-CSF Promotes Inflammatory Colon Carcinogenesis via Stimulating Epithelial Release of VEGF
Authors: Wang Yi , Han Gencheng , Wang Ke , Liu Guijun , Wang Renxi , Xiao He , Li Xinying , Hou Chunmei , Shen Beifen , Guo Renfeng , Li Yan , Chen Guojiang
Published: March 2023

PDF file - 429K, Fig. S1: GMCSFR expression in primary and transformed CEC. Fig S2: Receptors for IL-1, IL-6 and VEGF in CT26 cells. Fig. S3: GMCSF elicits IL-1β and IL-6. Fig. S4: Blocking GMCSF or VEGF decreases the number of proliferative epithelial cells. Fig. S5: Blocking GMCSF or VEGF regulates cell cycle gene expression in CEC. Fig. S6: GMCSF elicits VEGF expression in HCT116 cells. Fig. S7: TLR4 expression in primary and transformed CEC.
Supplementary Table 2 from CBP Loss Cooperates with PTEN Haploinsufficiency to Drive Prostate Cancer: Implications for Epigenetic Therapy
Authors: Ding Liya , Chen Shuai , Liu Ping , Pan Yunqian , Zhong Jian , Regan Kevin M. , Wang Liguo , Yu Chunrong , Rizzardi Anthony , Cheng Liang , Zhang Jun , Schmechel Stephen C. , Cheville John C. , Van Deursen Jan , Tindall Donald J. , Huang Haojie
Published: March 2023

PDF file - 66KB, Supplemental Table S2. The incidence of prostatic intraepithelial neoplasia (PIN) lesions detected in prostate-specific Cbp homozygous and Pten heterozygous deletion (Cbppc-/-;Ptenpc+/-) mice at 4 and 6 months of age and their littermate controls, including Cbp homozygous deletion alone (Cbppc-/-), Pten heterozygous deletion alone (Ptenpc+/-) and 'wild type' loxp (CbpL/L;PtenL/+) mice.
Supplementary Figure Legend from IRP2 Regulates Breast Tumor Growth
Authors: Wang Wei , Deng Zhiyong , Hatcher Heather , Miller Lance D. , Di Xiumin , Tesfay Lia , Sui Guangchao , D'Agostino Ralph B. , Torti Frank M. , Torti Suzy V.
Published: March 2023

PDF file - 59K
Supplementary Figure 1 from NUP98 Fusion Oncoproteins Promote Aneuploidy by Attenuating the Mitotic Spindle Checkpoint
Authors: Salsi Valentina , Ferrari Silvia , Gorello Paolo , Fantini Sebastian , Chiavolelli Francesca , Mecucci Cristina , Zappavigna Vincenzo
Published: March 2023

PDF - 2289K, Supplemental Figure 1. Expression of NUP98 and of NUP98 fusion oncoproteins in HEK293 cells. A, Schematic representation of the structures of human NUP98 (AAC50366) and of its chimeric oncoproteins. The GLFG repeats and the Rae1-interacting GLEBS domain are shown as black and dark grey boxes, respectively. The N-terminal portion of NUP98 is similar in the studied chimeras, spanning aa 1 to aa 469 in NUP98-HOXD13, and aa 1 to aa 514 in NLOC and NHHEX fusions. The HOXD13 (aa 252 to 335, AAC51635), LOC348801 isoform1 (aa 1 to 178, AAI26363), and HHEX (aa 140 to 270, NP_002720) C-terminal moieties are shown as coloured boxes. The homeodomain regions (HD) of HOXD13 and HHEX are indicated as a grey box within the coloured one. Also shown is the structure of NUP98-HOXD13IQN, which carries mutations of three amino acids within the homeodomain (white), impairing DNA binding. B, Western blot analysis showing the expression levels of the indicated proteins transiently expressed in HEK293 cells (T0), and after Nocodazole treatment at the indicated time points. Immunoblottings were performed with anti-NUP98 and anti-betaactin antibodies as a loading control.
Supplementary Table 1 from Sox2 Is Required to Maintain Cancer Stem Cells in a Mouse Model of High-Grade Oligodendroglioma
Authors: Favaro Rebecca , Appolloni Irene , Pellegatta Serena , Sanga Alexandra Badiola , Pagella Pierfrancesco , Gambini Eleonora , Pisati Federica , Ottolenghi Sergio , Foti Maria , Finocchiaro Gaetano , Malatesta Paolo , Nicolis Silvia K.
Published: March 2023

XLS file - 231KB, Excel file with the DEG genes from microarrays analysis.
Supplementary Figures 1 - 4 from Genetic and Phenotypic Diversity in Breast Tumor Metastases
Authors: Almendro Vanessa , Kim Hee Jung , Cheng Yu-Kang , Gönen Mithat , Itzkovitz Shalev , Argani Pedram , van Oudenaarden Alexander , Sukumar Saraswati , Michor Franziska , Polyak Kornelia
Published: March 2023

PDF file - 3207K, Representative examples of box plots depicting BAC/CEP ratios for the indicated chromosomal regions in two different metastatic sites (A and B) within the same patient (S1); Representative examples of kernel density and Whittaker plots (S2); Distribution of genomic variability (S3); Genetic differences between adjacent cells (S4).
Supplemental Figure 1 from Mitochondrial MKP1 Is a Target for Therapy-Resistant HER2-Positive Breast Cancer Cells
Authors: Candas Demet , Lu Chung-Ling , Fan Ming , Chuang Frank Y.S. , Sweeney Colleen , Borowsky Alexander D. , Li Jian Jian
Published: March 2023

Supplemental Figure 1. Mitochondrial membrane potential of MCF7 wt, C6 and HER2 cells
Data Supplement from Pyrvinium Attenuates Hedgehog Signaling Downstream of Smoothened
Authors: Li Bin , Fei Dennis Liang , Flaveny Colin A. , Dahmane Nadia , Baubet Valérie , Wang Zhiqiang , Bai Feng , Pei Xin-Hai , Rodriguez-Blanco Jezabel , Hang Brian , Orton Darren , Han Lu , Wang Baolin , Capobianco Anthony J. , Lee Ethan , Robbins David J.
Published: March 2023

Legend for Supplementary Figures S1-S3.
Supplementary Table and Figure Legends from BRG1/SMARCA4 Inactivation Promotes Non–Small Cell Lung Cancer Aggressiveness by Altering Chromatin Organization
Authors: Orvis Tess , Hepperla Austin , Walter Vonn , Song Shujie , Simon Jeremy , Parker Joel , Wilkerson Matthew D. , Desai Nisarg , Major Michael B. , Hayes D. Neil , Davis Ian J. , Weissman Bernard
Published: March 2023

Supplementary Table and Figure Legends