bluuebunny/crossref_metadata_2025 huggingface dataset:
ATRIAL FIBRILLATION AND QUALITY OF LIFE OF PATIENTS RECEIVING VARIOUS GROUPS OF INDIRECT ANTICOAGULANTS
Authors:   Kazan State Medical University, ISHMURZIN GENNADY P. , PODOLSKAYA ALLA A. ,   City Clinical Hospital No. 7 named after M.N. Sadykov, Kazan
Published: January 2025

Abstract. Introduction. Atrial fibrillation remains one of the most common cardiac arrhythmias. Due to the world’s
population aging, it is predicted that the number of patients with atrial fibrillation will reach 14-17 million people in
Europe alone by 2030 and only continue to increase annually. The presence of this arrhythmia is associated with an
increased risk of life-threatening thromboembolic complications. At the same time, a balanced and reasonable choice
of anticoagulant therapy determines the prognosis of patients with atrial fibrillation. Aim. To analyze the physical and
mental health components and coagulogram parameters in patients with atrial fibrillation, associated with receiving
different groups of indirect anticoagulants. Materials and Methods. The study involved 50 patients diagnosed with
atrial fibrillation and stayin in the therapeutic department of one of clinical hospitals in Kazan. All patients were divided
into groups according to the form of atrial fibrillation, as well as into subgroups for taking warfarin, taking new oral
anticoagulants, and without anticoagulant therapy being prescribed. Physical and mental health components were
assessed out using the SF-36 questionnaire. Results and Discussion. The best indicators of the physical health
component were found among patients with permanent atrial fibrillation taking warfarin, while the worst indicators were
in the group of persistent atrial fibrillation who did not take anticoagulants at all. The mental health component was
assessed higher in patients with persistent atrial fibrillation taking new oral anticoagulants, while the lowest values were
observed among patients with persistent atrial fibrillation taking warfarin. According to the coagulogram data, there were
no honestly significant differences among patients taking various groups of anticoagulants. Conclusions. In general,
patients with atrial fibrillation may have insufficient adherence to anticoagulant treatment, which is associated with affordability, as well as the patient’s low awareness of atrial fibrillation complications. The data obtained indicate that
the physical health component is higher and coagulogram indices are better in patients with permanent atrial fibrillation
taking warfarin, whereas the best mental state is observed in patients taking new oral anticoagulants.
IMPACT OF CORONAVIRUS INFECTION AND SARS-COV-2 VACCINATION ON THE COURSE OF CHRONIC URTICARIA
Authors:   City Clinical Hospital No. 7 named after M.N. Sadykov, Kazan, KLYUCHAROVA ALIYA R. , DELIAN VICTORIA Y. ,   City Clinical Hospital No. 7 named after M.N. Sadykov, Kazan
Published: January 2025

Abstract. Introduction. According to its definition, urticaria refers to a group of diseases characterized by the
development of wheals, angioedema, or both. Most often, chronic urticaria is triggered by stress, hormonal drugs,
consumption of products containing food colorants, preservatives, gastrointestinal diseases, autoimmune pathology,
as well as by infections, including COVID-19. Due to the fact that the coronavirus epidemic set on relatively recently,
the effect of this virus, as well as of SARS-CoV-2 vaccination, on the course of chronic urticaria has not been studied
in sufficient detail. Aim. Evaluation of the impact of SARS-CoV-2 and COVID-19 vaccination on the course of chronic
urticaria. Materials and Methods. The impact of SARS-CoV-2 and COVID-19 vaccination on the course of chronic
urticaria was assessed in 100 patients from 2021 to 2023, using the questionnaire developed and the UCT questionnaire.
Patients aged 39±15 years participated in the survey. Results and Discussion. The duration of chronic urticaria in
most respondents (58%) was more than 2 years, and in only 7% less than a year. According to the UCT results, urticaria
symptoms were controlled in 67% of patients before the SARS-CoV-2 epidemic. 64 people recovered from COVID-19;
however, exacerbation of urticaria associated with SARS-CoV-2 was observed in 35.9% of patients, while the disease onset was found in 3.1% of them. It should be noted that exacerbation of urticaria developed during COVID-19 persisted
in all patients for 3 months, and in a half of them for 6 months after the infection. 67 patients were vaccinated against
COVID-19: 63 with Gam-COVID-Vac and 4 with CoviVac, while immunoprophylaxis was not recommended for 15 patients
due to their uncontrolled urticaria. 23.8% patients vaccinated with Gam-COVID-Vac experienced fever and headache
on the first day. Only 8% of patients experienced exacerbation of urticaria. Conclusions. Patients with chronic urticaria
usually have a mild form of COVID-19. However, SARS-CoV-2 causes exacerbation or onset of urticaria in 35.9% of
cases. Vaccination with Gam-COVID-Vac is well tolerated by patients with chronic urticaria, and only 8% of patients
experience exacerbation of the disease.
OSTEOPOROSIS RISK IN WOMEN WITH BREAST VASCULAR CALCIFICATIONS REVEALED AT MAMMOGRAPHY
Authors:   Medical Institute of Mari State University, PASYNKOVA OLGA O. , KRASILNIKOV ALEXEI V. ,   Republic’s Clinical Veterans’ Hospital, Yoshkar-Ola, PASYNKOV DMITRY V. ,   Kazan State Medical Academy, KLYUSHKIN IVAN V. ,   City Clinical Hospital No. 7 named after M.N. Sadykov, Kazan, FATIKHOV RUSLAN I. ,   City Clinical Hospital No. 7 named after M.N. Sadykov, Kazan
Published: January 2025

Abstract. Introduction. Calcium salt deposits in the breast vessel walls can share the mutual mechanisms compared
to the ones of bone tissue mineralization mediated by the osteoprotegerin or receptors of the protein glycation end
products. Aim: To assess the risk of osteoporosis or other mineral turnover disturbances in women with breast vascular
calcifications found on mammography. Materials and Methods. Our study included 189 female patients who underwent
mammography in 2018 and then were followed up to the year 2023. They were divided into the three groups: No
calcifications group, moderate (grade 1-2) calcifications group, and pronounced (grade 3-4) calcifications group. All
the patients underwent screening mammography, the dual-energy X-ray absorptiometry, and serum biochemistry tests
(25-hydroxyvitamin D, total and ionized calcium, phosphorus, and magnesium). Results and Discussion. In 2018, 57
(30.16%) patients had breast vascular calcifications. The increased calcification degree was associated with the age.
The most significant changes were found in TBS T-score values: In the moderate calcifications group, it was 27.5%
lower compared to the no calcifications group (p=0.042); while in the pronounced calcifications group, it was 41.7%
lower compared to the no calcifications group (p=0.007). Conclusions. Breast vascular calcifications are associated
with the significant drop of TBS T-score values (from -2.31 to -3.97; р=0.008).
ASSOCIATION OF BREAST VASCULAR CALCIFICATIONS AT MAMMOGRAPHY WITH GASTROINTESTINAL TRACT PATHOLOGY
Authors:   Kazan State Medical Academy, PASYNKOV DMITRY V. , KRASILNIKOV ALEXEI V. ,   Republic’s Clinical Veterans’ Hospital, Yoshkar-Ola, PASYNKOVA OLGA O. ,   Medical Institute of Mari State University, KLYUSHKIN IVAN V. ,   City Clinical Hospital No. 7 named after M.N. Sadykov, Kazan, FATIKHOV RUSLAN I. ,   City Clinical Hospital No. 7 named after M.N. Sadykov, Kazan
Published: January 2025

Abstract. Introduction. Calcium deposits in the breast vessels can be related to the calcium absorption disturbances
in the gastrointestinal tract. Aim is to assess the association of the gastrointestinal pathology risk in women with breast
vascular calcifications found at mammography. Materials and Methods. We included 193 patients examined using
mammography in 2018. They were then followed up to the year 2023 and divided into two groups: No-calcification group
and detectable-calcification group. Gastrointestinal pathology was registered in patient medical records. Results and
Discussion. In 2018, 66 (34.2%) patients had breast vascular calcifications. In the detectable-calcification group, the
nonspecific intestinal motility disorders were observed two times more frequently compared to the no-calcification group
(relative risk [RR]: 2.34; 95%, confidence interval [CL]: 1.04 – 5.38; p=0.037). On the contrary, in the no-calcification group
the rate of both esophagitis and gastroesophageal reflux was 4 timed higher than in the detectable-calcification group
(RR: 4.29; 95%, CI: 0.95 – 19.34, p=0.041). At the end of the follow-up, the gallbladder stones were found approximately
2 times more frequently in the detectable-calcification group (ОР=2.22; 95%, CI: 1.15 – 4.3; p=0.017). Conclusions.
The detectable breast vascular calcifications were associated with the higher gallbladder stones risk during subsequent
6 years (RR: 4.8; 95%, CI: 1.55 – 14.92; р=0.003) compared to the no-calcification group (4.7% versus 19.2%). At the
same time, we found no association of the detectable breast vascular calcifications with the risk of hepatic steatosis /
nonalcoholic fatty liver disease, gastritis, gastro-duodenitis, hiatal hernia, or pancreatitis.
ABDOMINAL WALL ENDOMETRIOSIS: A MULTIDISCIPLINARY APPROACH (Literature review)
Authors:   Kazan State Medical University, GABIDULLINA RUSHANIA I. , MINNULLINA FARIDA F. ,   Kazan Federal University, SYRMATOVA LYAJSAN I. ,   City Clinical Hospital No. 7 named after M.N. Sadykov, Kazan, MAMETOVA NAILIA A. ,   Kazan State Medical University
Published: January 2025

Abstract. Introduction. Abdominal wall endometriosis characterized by the presence of ectopic endometrial glands or
stroma in the abdominal wall, is a rare form of extragenital endometriosis, but can have a significant negative impact on
the quality of women’s life. Abdominal wall endometriosis is mostly iatrogenic and is associated with cesarean section
or gynecological operations involving hysterotomy. Given the steady increase in the frequency of cesarean sections, it
is expected that the number of cases of abdominal wall endometriosis will continue to grow. Aim: To provide updated
information on abdominal wall endometriosis from an interdisciplinary perspective. Materials and Methods. A review of
publications based on research using the keywords endometriosis, abdominal wall endometriosis, scar endometriosis,
cesarean section scar endometriosis, umbilical endometriosis, and inguinal endometriosis, based on search results in
electronic resources in Russian and international systems (eLibrary, PubMed, MedLine, and Crossref) for the last 7 years,
from 2017 to 2024. Results and Discussion. Abdominal wall endometriosis occurs with a frequency of 0.04%–5.5%. A
typical manifestation is a painful formation in the abdominal wall. The pain syndrome intensity may be determined by the
menstrual cycle phase. Endometrioid foci can develop primarily (spontaneously) and secondarily in the postoperative
scar area. By localization, abdominal wall endometriosis is divided into cicatricial, umbilical, and inguinal. The average
age as of diagnosis is 32-36 years, while the time from surgery to endometriosis identification varies from 3 months
to 2 decades. Clinically, the diagnosis is established in 20-50% of cases, and with using additional imaging methods,
such as ultrasound, CT, and MRI, this level reaches 70%. Cases of malignant transformation are extremely rare and
amount to about 1%. The question remains controversial regarding the relationship of abdominal wall endometriosis to
the presence of other concomitant endometriosis forms. Currently, the gold standard of treatment is wide excision of
endometrioid foci, including the surrounding fibrous tissue. The recurrence rate varies from 1.5 to 28.6%. Conclusion.
Interdisciplinary collaboration involving gynecologists, surgeons, imaging specialists, and pathologists is necessary for
early diagnosis and optimization of abdominal wall endometriosis patient treatment.
POSTOPERATIVE VENTRAL HERNIAS: UNRESOLVED ISSUES OF DIAGNOSIS AND SURGERY TACTICS
Authors:   Kazan State Medical University, DOBROKVASHIN SERGEY V. , IZMAILOV ALEXANDER G. ,   Kazan State Medical University, YANTYKOVA AZALIA A. ,   Kazan State Medical University, OVCHINNIKOV PAVEL D. ,   Kazan State Medical University, VOLKOV DMITRY E. ,   Kazan State Medical University, KLYUSHKIN IVAN V. ,   City Clinical Hospital No. 7 named after M.N. Sadykov, Kazan, FATIKHOV RUSLAN I. ,   City Clinical Hospital No. 7 named after M.N. Sadykov, Kazan
Published: January 2025

Abstracts. Introduction. Postoperative ventral hernias are formed in 15-30% of cases after abdominal surgeries.
Patients with postoperative ventral hernias rank 2nd after inguinal hernias, accounting for up to 22% of the total number
of abdominal hernias. The advent of tension-free hernioplasty using synthetic implants helped solve some herniology
issues: Number of relapses in the late postoperative period has significantly decreased. Aim of the study was to analyze
the literature in accordance with modern problems regarding the surgical approaches to the treatment of postoperative
ventral hernias. Materials and Methods. The literature review was made using the method of searching for publications
in the PubMed databases. Results and Discussion. Computed tomography is the most informative in diagnosing the
condition of the anterior abdominal wall tissues in patients with postoperative ventral hernias. The fundamental issue is
the choice of abdominal wall layers for placing and strengthening the implant. An implant can be placed in the abdominal
wall layers by different methods: Intraperitoneal, preperitoneal, retromuscular, and, in some cases, subaponeurotic
and supra-aponeurotic. Conclusions. The use of combined methods of plastic surgery of the anterior abdominal wall
for large postoperative ventral hernias using the sublay-inlay technique allows avoiding high traumatic effect of the
operation and reducing the recurrence rate. In case of large postoperative ventral hernias, improving the optimal open
surgery methods remains relevant.
PERIODIC MEDICAL EXAMINATIONS: THEIR EFFECTIVENESS AND ROLE IN EARLY DETECTION OF DISEASES
Authors:   Kazan State Medical University, GARIPOVA RAILYA V. , BERKHEEVA ZUKHRA M. ,   Kazan State Medical University, MIFTAKHOVA SVETLANA N. ,   City Clinical Hospital No. 7 named after M.N. Sadykov, Kazan, GALIULLIN ILGIZ M. ,   City Clinical Hospital No. 7 named after M.N. Sadykov, Kazan, SAFINA KADRIYA R. ,   Republican Сenter of Occupational Diseases, Kazan, ARKHIPOV EVGENY V. ,   Kazan State Medical University, ISHTERYAKOVA OLGA A. ,   Kazan State Medical University, SABITOVA MINZILYA M. ,   Kazan State Medical University
Published: January 2025

Abstract. Introduction. Periodic medical examinations are aimed at dynamic monitoring of the employees’ health
status and timely detection of occupational and somatic diseases. Aim of the study is to assess the effectiveness of
periodic medical examinations for the years 2019-2023, based on the analysis of annual reports of 45 territories of the
Republic of Tatarstan. Materials and Methods. The study used annual reports of the republic’s and city centers of
occupational pathology. For statistical analysis, the methods of descriptive statistics and tabular presentation were used,
qualitative indicators are presented as absolute (n) and relative values (%) of the occurrence of the feature studied.
To study the differences in qualitative features of several populations, the c2 (chi-square) criterion was used. Results
and Discussion. About 300 thousand employees undergo periodic medical examinations in the republic annually
(297,313 people in 2019, 277,291 in 2020, 273,294 in 2021, 316,508 in 2022, and 307,437 in 2023). On average, the
coverage of periodic medical examinations is 96-97%. In 2023, cases of occupational diseases were registered in
15 administrative territories, including Kazan and Naberezhnye Chelny (19 in 2019, 20 in 2020, 20 in 2021,and 27 in
2022). For the first time, 32,216 chronic somatic diseases were identified in 2023, accounting for 10.5% of all those who
underwent periodic medical examinations (7.9 % in 2022, 11.7% in 2021, 11.2% in 2020, and 11.7% in 2019). It is still
problematic to organize medical examinations of those employed by agricultural enterprises. Not all eligible persons
undergo a medical examination; at many enterprises, medical examinations are carried out only for those belonging
to decreed groups and/or working in contact with pesticides. Conclusions. An important prerequisite for the timely
detection of initial forms of occupational and somatic diseases, early signs of the impact of harmful production factors
on the employees’ health with the subsequent formation of risk groups for the development of occupational diseases
should be mandatory periodic medical examinations conducted in the center of occupational pathology for persons with
5 years of working experience in harmful working conditions, with repeatedly conducting the same once every 5 years.
Industrial medical examinations contribute to the detection of diseases at early stages.
MASKS OF ACUTE CEREBROVASCULAR ACCIDENTS IN YOUNG PEOPLE: POSTERIOR REVERSIBLE ENCEPHALOPATHY SYNDROME
Authors:   City Clinical Hospital No. 7 named after M.N. Sadykov, Kazan, VALEEVA KADRIA G. , VASKAYEVA GULNAZ R. ,   City Clinical Hospital No. 7 named after M.N. Sadykov, Kazan, DANILOVA TATIANA V. ,   Kazan State Medical University
Published: January 2025

Abstract. Introduction. Posterior Reversible Encephalopathy Syndrome is a clinical radiological syndrome characterized
by acute, potentially reversible vasogenic edema of the subcortical white matter of the brain, predominantly involving
the occipital and parietal lobes. Aim was to discuss the difficulties in diagnosing this syndrome. Material and Methods.
A clinical case of a patient was analyzed, who had been admitted to a medical facility with acute severe neurological
symptoms arising from uncontrolled arterial hypertension and kidney pathology. Results and Discussion. The patient
manifested an acute development of the disease, severe headache, focal neurological symptoms, confusion, epileptic
seizure, and the characteristic signs of the disease on neuroimaging. Conclusions. This clinical case illustrates the
variety of predisposing factors and clinical and radiological manifestations of the posterior reversible encephalopathy
syndrome. The case presented emphasizes the importance of including posterior reversible encephalopathy syndrome
in the differential diagnosis of acute neurological symptoms, especially in the presence of risk factors, such as arterial
hypertension, alcohol exposure, kidney pathology, and previous brain injuries; and it also demonstrates the key role of
magnetic resonance imaging in diagnosing and preventing potentially irreversible brain changes
ACUTE GENERALIZED EXANTHEMATOUS PUSTULOSIS: A SHORT REVIEW AND CASE REPORT
Authors:   City Clinical Hospital No. 7 named after M.N. Sadykov, Kazan, DELIAN VICTORIA Y. , KLYUCHAROVA ALIYA R. ,   City Clinical Hospital No. 7 named after M.N. Sadykov, Kazan, ZAKIROVA GUZEL N. ,   City Clinical Hospital No. 7 named after M.N. Sadykov, Kazan, IAKOVLEVA KSENIIA A. ,   Kazan State Medical Academy
Published: January 2025

Abstract. Introduction. Acute generalized exanthematous pustulosis is a rare cutaneous adverse drug reaction.
The disease has a complex development mechanism, involving various subpopulations of T cells and monocytes,
characterized by a genetically determined imbalance in IL-36 signaling. This reaction has an acute onset, a variety
of clinical manifestations, and a self-limited course after drug discontinuation. Aim: Exemplifying by our own clinical
observation, to present an algorithm for diagnosing and managing acute generalized exanthematous pustulosis. Material
and Methods. Patient Kh., 55 years old, was hospitalized in the vascular neurology department due to ischemic stroke
in the posterior circulation system, in the form of vestibulopathy, and left hemiataxia, unspecified pathogenetic subtype.
Abundant itchy pustules appeared on the skin of the trunk, upper and lower extremities, weakness, lethargy, and
body temperature increase up to 38–38.5ºС on the 4th day of treatment. General clinical, laboratory, and instrumental
examination methods were used. Results and Discussion. Examination revealed extensive foci of edematous
erythema, multiple non-follicular small pustules, an increase in the absolute number of neutrophils to 18,500 cells/μl and
eosinophils to 1,250 cells/μl in the general blood test, a moderate increase in the levels of liver transaminases in the
biochemical analysis, and a slight pleural effusion on the right in ultrasound. The use of the EuroSCAR scale, based on
the assessment of clinical symptoms, morphology of skin lesions, and histological picture of the disease, helped set a
correct diagnosis and choose a patient management approach. The patient received treatment with systemic and local
glucocorticosteroids, manifesting with good positive changes. Conclusions. Using the EuroSCAR scale developed
by a team of international experts helps set the diagnosis of acute generalized exanthematous pustulosis. Immediate
discontinuation of the causally significant drug is a prerequisite for successful patient management. Local therapy using
disinfectant solutions, topical glucocorticosteroids, and moisturizing lotions is the initial approach to managing a patient
with acute generalized exanthematous pustulosis.
PEMBUATAN SISTEM PENGGERAK MESIN CETAK PELET IKAN
Authors: Habib Ramadhan Muhammad , Sulaiman Sulaiman , Eka Putra Ismet
Published: January 2025

Industri perikanan merupakan salah satu sektor penting dalam perekonomian Indonesia. Salah satu aspek krusial dalam budidaya ikan adalah pemberian pakan yang berkualitas tinggi dan kontinu. Pelet ikan menjadi pilihan utama karena kandungan nutrisinya yang seimbang dan kemudahan dalam penggunaannya. Selama ini, pelet ikan yang tersedia di pasaran sering kali didatangkan dari produsen besar yang menguasai pasar. Oleh karena itu, diperlukan alternatif solusi yang memungkinkan peternak untuk memproduksi pelet ikan sendiri dengan kualitas yang dapat diandalkan dan biaya yang lebih ekonomis.Pembuatan sistem penggerak pada mesin cetak pelet ikan merupakan upaya untuk meningkatkan efisiensi produksi pakan ikan yang berkualitas dan terjangkau. Prinsip kerja sistem penggerak ini menggunakan mekanisme konversi energi mekanik dari motor listrik ke komponen penggiling dan pencetak. Motor listrik berfungsi sebagai sumber utama tenaga, yang kemudian ditransmisikan melalui sistem roda gigi atau sabuk ke bagian penggiling untuk menghancurkan bahan baku dan mencetak pelet sesuai ukuran yang diinginkan.Proses pembuatan sistem penggerak melibatkan perhitungan putaran pulley mesin 1400 rpm sedangkan putaran pulley yang digerakkan adalah 437,5 rpm,kecepatan sabuk 464 cm/s dan torsinya 1.660.80 kg.mm. Hasil pengujian menunjukkan bahwa mesin mampu menghasilkan pelet setelah dilakukan 3 kali pengujian dengan variasi berat bahan baku pelet ,maka didapatkan hasil pengujian pertama 15,65 kg/jam,pengujian kedua 26,47 kg/jam dan yang ketiga 26,67 kg/jam serta hasil rata ratanya adalah 68,79 kg/jam.
Open Science at the University of Toronto
Authors: Burt-D'Agnillo Madelin , Thuna Mindy
Published: January 2025

Objective: The impetus for this project is to begin to understand open science practices and obstacles at the XXX. This project uses open-ended questions to understand the ways in which university-affiliated individuals learn about, think about, and interact with open science. The goal of this study is to showcase the complexity and diversity of activity and challenges in this domain to help determine how best to move open science forward.
Methods: From March to October 2022, 45 semi-structured interviews were conducted with faculty, graduate students, librarians and administrative staff. Interviews were conducted and recorded using Zoom and the audio was transcribed using otter.ai. As part of a commitment to open science practices, a data management plan was created and with participant consent, 26 transcripts were uploaded to Dataverse. Data analysis used structured coding and thematic development to investigate responses.
Results: The core finding of this study is that there is no singular status of open science at XXX. The qualitative findings reflect a diversity of opinions, practices and relationships to open science.
Conclusion: For open science practices and scholarship to have longevity, there must be systemic changes to adopt more open activities. XXX is well positioned to guide the transition and harness open principles to move into the future.
EUS Directed Trans-gastric Gastroenterostomy for Gastric Remnant Outlet Obstruction after Roux-en-Y Gastric Bypass Surgery
Authors: Margolis Victoria , Pawa Rishi
Published: January 2025

1. EUS directed gastro-gastrostomy using lumen apposing metal stent has greatly enhanced the ability to perform trans-gastric interventions after Roux-en-Y gastric bypass surgery.
2. The use of this minimally invasive technique in terminally ill patients with gastric outlet obstruction of the excluded stomach allows for prompt diagnosis by providing access to the bypassed stomach and is therapeutic by allowing drainage via the Roux limb.
3. EUS-guided gastroenterostomy (via the excluded stomach) may help in alleviating reflux symptoms in patients following creation of gastro-gastric anastomosis.
The de novo mutation of KIF1A gene as the cause for Spastic paraplegia 30 in a Turkish casein a case
Authors: BARIŞ Savaş , CAN Ender
Published: January 2025

Background
Hereditary spastic paraplegias (HSPs) are a group of clinically and genetically distinct neurodegenerative diseases characterized by progressive stiffness and lower limb paralysis. There are currently up to 79 loci [spastic paraplegia [SPG]] known to exist. A family with early childhood-onset HSP was reported due to a homozygous mutation in KIF1A (Kinesin family member 1A) in 2011. KIF1A, located on the long arm of chromosome 2 [2q37.3], is the cause of its regulated sensory and autonomic neuropathy type 2 [HSAN2]. A heterozygous KIF1A mutation has also been implicated in nonsyndromal intellectual disability [mental retardation, autosomal dominant 9:MRD9].
Case presentation
Here, we describe a boy who was 13 years old who had minor mental impairment, epileptic seizures as he grew older, hypotonia in infancy, and finally, spastic paraplegia [autosomal dominant inheritance]. Exome analysis detected a de nova heterozygous KIF1A mutation [c.1031c > t p.thr344met] in this male.
Conclusions
The alteration identified by the patient's exome study substitutes neutral and non-polar methionine for neutral and polar threonine at the 344th codon of the KIF1A protein [p.Thr344Met]. According to the literature searches, it was observed that the variant was present in at least one individual. We believe that this change in the motor region of the gene causes spastic paraplegia and mental retardation in individuals with clinical features of autosomal dominant KIF1A-related conditions and also causes previously unidentified epileptic attacks. The conformational change in the protein structure [structural, mechanical] disrupts the protein's function. Therefore, we consider it a pathogenic variant.
COVID-Related Mental Health and Smoking in Sexual Minority Women
Authors: Branstetter Steven A
Published: January 2025

Sexual minority women face a range of health disparities, including high rates of mental health issues, alcohol and tobacco use, obesity, stroke, and general poorer health compared to heterosexual women.  The minority stress model describes how members of a minority group, including sexual minorities, face unique stressors related to a stigmatized social status. Research has shown that sexual minorities who face increased discrimination, as described in the minority stress model, tend to have increased smoking rates. The present study sought to examine how increased mental health-related stress associated with the COVID-19 pandemic impacted the smoking behaviors of sexual minority women. Data from the 2021 National Survey on Drug Use and Health were used to build OLS regression and mediation models determining how female sexual minority status moderated the relation between COVID-19-related impacts on mental health and smoking. Results found that sexual minority women with the highest levels of negative impacts on mental health as a result of COVID-19 smoked the fewest cigarettes as compared to heterosexual women. The finding that high levels of mental health distress are related to a reduction in smoking among sexual minority women warrants further research to examine if this effect is COVID-19-specific, or a more generalized pattern of stress and mental health impacts on smoking behavior.
Role of Manthana Samskara in the preparation of Khajitha Pinda Taila
Authors: Ashok Kumar B N  , Kotresh B M
Published: January 2025

The term "Bhaishajya" denotes "drug" or "medicine," whereas "Kalpana" pertains to "preparation." Bhaishajya Kalpana encompasses the application of various medicinal substances and adheres to specific principles outlined in ancient Ayurvedic scriptures. This discipline is divided into two primary principles: Aushadha Nirmana (the Principle of Formulation) and Aushadha Prayoga (the Principle of Therapeutic Application). A thorough understanding of these core concepts is vital for effective research and development in Ayurvedic pharmaceutics. Sneha Kalpana is one among those preparations derived from the basic Kalpanas prepared using either Ghritha or Taila. The transformation of properties into the Sneha Dravya is made possible by the use of various Samskaras. Manthana Samskara is believed to help in the proper mixing of two substances and also imbibe Sheeta Guna to the formulation. It is considered to give a homogenous mixture thereby improving the product’s stability to a greater extent. Pinda Taila is one such Yoga mentioned in our classics for the relief of Daha and Shoola developed in Vatarakta after subjecting it to Khajita Samskara/Manthana Samskara.
A review of Mamsgatavata with special reference to Fibromyalgia
Authors: Shalu Singhal  , Gopesh Mangal
Published: January 2025

Mamsgatavata is a condition in Ayurveda where aggravated Vata Dosha affects the muscles (Mamsa Dhatu), leading to symptoms like pain, stiffness, and muscle weakness. This concept closely aligns with fibromyalgia, a modern medical condition characterized by widespread musculoskeletal pain, fatigue, and cognitive disturbances. The Ayurvedic approach to managing Mamsgatavata focuses on pacifying Vata through dietary and lifestyle adjustments, herbal remedies, and therapeutic interventions like Panchakarma. This holistic approach targets the root causes of fibromyalgia, emphasizing long-term relief and the restoration of balance in both body and mind. By addressing physical, mental, and emotional health, Ayurveda provides a comprehensive framework for managing chronic conditions like fibromyalgia.
Psychological benefits of Bhramari Pranayama in Menopausal Women : A Review
Authors: Chaitali N. Turkane  , Sumeeta S. Jain
Published: January 2025

Menopause, occurring between ages 45-55, causes hormonal changes that often lead to psychological symptoms such as mood swings, anxiety, and sleep disturbances. About 20% of women experience these issues during menopause. Bhramari Pranayama, a breathing technique, is recognized for its therapeutic effects on psychological disorders. Aim and Objectives: To review psychological benefits of Bhramari Pranayama in menopausal women, to review the literature regarding Bhramari Pranayama, To review the literature regarding Menopause. Materials and Methods: Different literature from articles, journals and from classical texts of Ayurveda, modern science and Yoga were reviewed and analyzed. Discussion: The humming sound in Bhramari Pranayama, similar to Mantra repetition, and its impact on breathing rhythm may help alleviate psychological issues in menopausal women. Conclusion: Bhramari Pranayama would be more beneficial to combat the psychological issues occurring in the menopausal women.
A Literary Review of Kansya (Bell Metal)
Authors: Sonbhoyar Devaki  , Dongre Sushma
Published: January 2025

Kansya is a metallic alloy known as Bell metal worldwide typically comprised of 78% copper and 22% tin. The classical texts divided Loha or Dhatus into three categories i.e., Shuddha Loha, Puti Loha, and Mishra Loha. Kansya is popularly categorized under Mishra Loha. As per the description available in Rasa Granthas Kansya constitutes of Tamra (Copper) and Vanga (Zinc) in a 4:1 proportion. Kansya was processed into Bhasma through the Shodhana and Marana processes. Aim and Objectives: To review classical literature on Kansya along with pharmaceutical process of Shodhana and Marana for preparation of Kansya Bhasma. Material and Method: All the classical literature in Rasagrantha, Samgraha Grantha, textbook of Ayurveda and Rasashastra regarding Kansya Bhasma. Observation and Result: The classical literature revealed that synonyms, vernacular name and type of Kansya from various classical text. The pharmaceutical process like Kansya Nirman Vidhi, Grahyagrahyatva Lakshana, Shodhana and Marana procedure is mentioned by various Acharyas. Therapeutic uses of Kansya Bhasma also mentioned in various text. Conclusion: This review was the compilation of information about Kansya compiled from different classical Rasa Shastra Texts. On reviewing the text, no or very little research information was quoted in regard to Kansya. There need to explore further study on Kansya Bhasma.
Ayurveda management against Non-Alcoholic Fatty Liver Disease: A Case Report
Authors: Drishti Aggarwal  , Rajendra Kumar Soni
Published: January 2025

Fatty liver disease is the accumulation of fat in the liver that can damage the organ and lead to serious health problems. It affects about one in ten people. It is normal for the liver to contain some fat. But if fat makes up more than 10 percent of the liver's weight, it means a fatty liver. This study shows the effectiveness of Ayurvedic medicine and its control measures in the management of Non-alcoholic Fatty Liver Disease, where the size of liver as 17cm was diagnosed through ultrasonography. A 36-year-old patient presented to the OPD of Department of Kayachikitsa, Ch. Brahm Prakash Ayurved Charak Sansthan, New Delhi with complaints of alteration in bowel habit, pain in abdomen and recurrent fever in the last one year. This case was diagnosed as Non- alcoholic Fatty Liver Disease on the basis of ultrasonography (USG) report. The patient was treated with Ayurvedic oral drugs and got satisfactory results. Satisfactory results were noted at the follow up after 2months. This study bear out that fatty liver disease can be successfully reversed with Ayurvedic treatment.
Ayurvedic management of Dengue Fever - A Case Study
Authors: Nikita V. Bhagwatkar  , Sujata Laddha
Published: January 2025

Dengue fever is the fastest spreading vector-borne virus disease, transmitted through the bite of female mosquitos of the Aedes aegypti species. Dengue fever has surged in recent decades, with estimates putting 40-50% of the world's population at risk for the disease[1] In Ayurveda, dengue fever can be correlated with Vishamjwara. Various formulations have been mentioned in Jwara Prakaran. A case study of dengue fever was done which was successfully managed with Ayurvedic medications. So, it can conclude that dengue fever can be managed without any side effect in Ayurveda. In this study 20 years old male patient with complaints of fever with chills, headache, body ache and itching over body was present. Blood investigations revealed dengue positive along with decreased platelets count. It was managed with Ayurvedic medications for 7 days and also developed good immunity against the disease. The subject was treated on the base of Vishamjwara with various formulations given in Jwara Prakaran. Lab tests were also done on time to monitor the changes. Symptomatology and haematological profile both significantly improved.
Ayurvedic management of Aradita (Bell’s Palsy) - A Case Study
Authors: Tanisha Jain  , A.P. Vaijwade
Published: January 2025

Introduction: Bell's palsy or Facial nerve palsy is a condition that causes temporary weakness or paralysis of the muscles in the face. In Ayurveda, Ardita is a disease with functional disturbances affecting the Uthamanga (head) and stands close with the symptoms of Bell's palsy. This is the most common idiopathic unilateral lower motor neuron facial palsy that usually develops suddenly. Bell's palsy is treated with steroids, anti-inflammatory drugs, antivirals, and multivitamins in contemporary science, although the results are not good and the use of steroids has health risks. Ayurveda has a wide spectrum in terms of management from internal medications to an extend limit of Kriyakalpas and Panchakarma like Nasya, Ksheeradhuma, Sweda, Netra Tarpana, Jalauka Avacharan. Case presentation: A 16-year male came to OPD with sudden left sided facial muscular weakness since 3 days ago. The treatment provided was Snehan, Shashtik Shali Pinda Sweda, Jalauka Avacharan, Nasya and Tarpan along with intake of Shamana medicines. Conclusion: The pre and post-assessment was done with the help of House-Brackmann facial nerve grading system. Within the period of 15 days the patient showed significant improvement without any adverse effects.
Beyond Traditional Engagement: An Empirical Assessment of the Nomological Network of the Human Spirit at Work
Authors: Kumar Vibhash
Published: January 2025

Engagement is a widely recognized concept globally, crucial for assessing and predicting job and organizational performance. However, some question the need for new constructs that resemble established ones. Similarly, workplace spirituality varies in academic definitions, challenging its validity. Yet, emerging literature suggests a clear link between spirituality at work (SAW) and engagement at work (EAW), both connected to the human spirit, albeit unexplored empirically. This research aims to establish epistemological congruence between EAW and SAW. Drawing on existing literature emphasizing their similarities, this study integrates them as 'Engagement of Human Spirit at Work' (EHSW). Analyzing two data samples (n1=166, n2=253 respondents) confirms a robust EHSW nomological network with interrelated antecedents and consequences. This study advances EHSW literature, strengthening the theoretical foundations of engagement and workplace spirituality. This study also discusses theoretical implications, bolstering these domains within academic discourse.
Modeling Consequences of Brand Authenticity in Anthropomorphized AI-Assistants: A Human-Robot Interaction Perspective
Authors: Pandey Palima , Rai Alok Kumar
Published: January 2025

The emergence of anthropomorphized AI Assistants can be linked to the advanced convergence of machine learning and natural language processing algorithms that could mimic human brains. Conversational-AI has led users to expect a sense of authenticity in their anthropomorphized assistants, more so, in a social context; which creates newer avenues for brands to better connect with their consumers. The present study aimed to develop a consequential model of AI-authenticity while drawing inferences from a series of human-robot interaction based theories, viz. “Computers as Social Actors” (CASA); “Media Equation” (ME), “Stereotype Content Model” (SCM) and “Socio-Cognitive Computational Trust” (SCCT) theory. Partial-Least-Square based Structural-Equation-Modeling was performed to examine the hypothesized framework; while, bootstrapping technique was utilized to better assess the effect of mediation analysis. The predictive relevance of the developed model was evaluated based on cross-validated redundancy approach. The findings designated ‘Emotional Attachment’, ‘Customer Engagement’ and ‘Cognitive Trust’ as major consequences of brand authenticity; while ‘warmth’was accounted as a positive, but weak mediator in authenticity-cognitive trust relationship, due to probable effects of uncanny valley phenomenon. ‘Cognitive Trust’remained a significant predictor of ‘continuous usage intentions’and ‘word-of[1]mouth’ behaviour. The proposed AI-authenticity framework could aid underpinning effective customer retention and extension strategies.
The principle of justice in the jurisdictional process: some problems in law enforcement
Authors: Belyaev V. P. , Belyaeva G. S.
Published: January 2025

Relevance. General theoretical study of the principle of justice in the legal process is relevant in light of the ever-increasing demand of our civil society for justice in general and in connection with its undeniable significance in legal proceedings - jurisdictional process. Study of the principle of justice from the standpoint of the general theory of law as a basic science enables branch sciences, such as criminal, civil, arbitration, administrative processes, to obtain the necessary information about the role and significance for them of the essence and content of the principle of justice as one of the basic principles in the system of procedural principles of modern jurisprudence. The purpose of this study is to attempt to show, based on the essence of justice as such, its determinacy of other principles of the legal process in general and its type - jurisdictional process, as well as individual problems in law enforcement in relation to this principle.

Objectives. To disclose the idea of this article, the following objectives were set and solved: to define the concept of jurisdictional process; to correlate the principles of law and legal principles, as well as the principle of justice with other principles; to identify some problems in the legislative consolidation of the principle of justice in the jurisdictional process.

Methodology. The methodological basis of the study includes general scientific techniques and methods of scientific knowledge, as well as special and specific scientific methods - formal-legal and interpretive.

Results. This study allows us to determine the role and significance of the principle of justice in the jurisdictional process in relation to other procedural principles and to note some gaps (indifference) in the legislation.

Conclusion. Given the unconditional significance of the principle of justice in the jurisdictional process, it is necessary to legislatively consolidate it in such procedural codes as the Criminal Procedure Code of the Russian Federation, the Civil Procedure Code of the Russian Federation and the Arbitration Procedure Code of the Russian Federation.
To the discussion on the return of the protocol form of pre-trial preparation of materials
Authors: Ryapolova Y. P.
Published: January 2025

Relevance. The article presents a retrospective view of the specifics of the application of pre-trial preparation of materials in protocol form in the context of a long-term discussion about the advisability of its reintroduction as an independent accelerated procedure for investigating minor crimes with an uncomplicated composition, an attempt is made to answer the pressing questions of whether the institution of protocol form of pre-trial proceedings is in demand now and what guidelines should be followed when preparing a regulatory framework for its recreation in modern conditions.

Purposes: to study the peculiarities of legislative regulation of the protocol form of pre-trial preparation of materials in a criminal case, to formulate mandatory conditions for the reintroduction of this institution into the system of domestic pre-trial proceedings.

Objectives: analysis of legislative regulation and practice of applying pre-trial preparation of case materials; comparative analysis of author's approaches justifying the feasibility of reintroducing the protocol form of pre-trial investigation; determination of the preferred vector of development of legislation in the field of consolidation of accelerated procedures for investigating crimes of minor gravity committed in the conditions of evidence.

Methodology. When writing the article, the method of legal modeling, as well as formal-logical, statistical, historical-legal, systemic and other methods were used.

The results of the study contain theoretical provisions justifying the need to modernize the existing procedure for expedited proceedings in cases of minor and obvious crimes, taking into account the experience of using the protocol form of preparing materials in the Soviet period.

Conclusion. The results of the study made it possible to identify the advantages and disadvantages of the protocol form of preparation of materials in comparison with the modern form of accelerated pre-trial investigation - inquiry in an abbreviated form ‒ and also to formulate general requirements for the development of a legal basis for recreating the proposed accelerated procedure for investigating uncomplicated and minor crimes.
Legal gaps and threats to public safety from free circulation of deactivated weapons using digital technologies: ways to improve criminal legislation
Authors: Zhilkin M. G. , Popov A. Y.
Published: January 2025

Relevance. Current weapons legislation of the Russian Federation does not take into account the impact of rapidly developing digital technologies on illegal arms trafficking. Deactivated weapons are freely sold on the Internet without the need for licensing, which creates legal gaps. Combined with the availability of information on weapon conversion and the availability of specialized components, these weapons can be easily modified to fire live ammunition, posing a serious threat to public safety.

Purpose: to study is to study the public danger of free circulation of deactivated weapons using digital technologies, as well as to develop proposals for improving criminal and other legislation to increase the effectiveness of combating crime in this area.

Objectives: include the analysis of legal gaps in the legislation regulating the circulation of deactivated weapons, the study of relevant judicial practice, the assessment of the impact of digital technologies on the distribution of deactivated weapons through Internet platforms and the availability of information on their modification, as well as the development of proposals for improving legislation and the differentiation of criminal liability.

Methodology. The research is based on general scientific methods of analysis and synthesis, as well as formal-logical, formal-legal and methods of interpretation of legal norms.

The results of the study show that the free circulation of deactivated weapons via the Internet creates conditions for their illegal modification and use for criminal purposes, which is confirmed by the analysis of judicial practice.

Conclusions. The authors propose to tighten the legislation on the circulation of deactivated weapons by introducing mandatory licensing, strengthening control over their sale and circulation through digital platforms, and clarifying the differentiation of criminal liability for the illegal circulation and modification of weapons.