bluuebunny/crossref_metadata_2025 huggingface dataset:
Plasma Glial Fibrillary Acidic Protein and Neurofilament-Light for the Diagnostic and Prognostic Evaluation of Frontotemporal Dementia
Authors: Zhu Nuole , Santos-Santos Miguel , Illán-Gala Ignacio , Montal Victor , Estellés Teresa , Barroeta Isabel , Altuna Miren , Arranz Javier , Muñoz Laia , Belbin Olivia , Sala Isabel , Sanchez-Saudinos Maria Belén , Subirana Andrea , Videla Laura , Blesa Rafael , Clarimón Jordi , Carmona-Iragui Maria , Fortea Juan , Lleó Alberto , Alcolea Daniel
Published: October 2021

Background: Astrocytes play an essential role in neuroinflammation and are involved in the pathogenesis of neurodenegerative diseases. The Study of Glial fibrillary acidic protein (GFAP), an astrocytic damage marker, may be helpful to better understand the different neurodegenerative diseases. We investigated the diagnostic performance of plasma GFAP (pGFAP), plasma neurofilament (pNfL) and their combination in frontotemporal dementia (FTD) and Alzheimer’s disease (AD). We studied their clinical utility in predicting disease progression. Methods: We measured pGFAP and pNfL concentrations in 72 FTD, 56 AD and 83 cognitively normal participants (CN) using Single Molecule Array technology. Of 211 participants, 199 had CSF and 122 had MRI. We compared cross-sectional biomarker levels between groups, studied their diagnostic performance and assessed correlation with CSF biomarkers, cognitive performance and cortical thickness. The prognostic performance was investigated analyzing cognitive decline between group comparisons by tertile. Results: Unlike pNfL, which was increased similarly in both clinical groups, pGFAP was increased in FTD but lower than in AD (all p<0.01). The combination of both plasma markers improved the diagnostic performance to discriminate FTD from AD (combination AUC 0.78; pGFAP AUC 0.7; pNfL AUC 0.61, all p<0.05). In FTD, pGFAP correlated with cognition, CSF and plasma NfL, and cortical thickness (all p<0.05). The higher tertile of pGFAP was associated with greater change in MMSE score and poor cognitive outcome during follow-up both in FTD (1.40 points annually, HR 3.82, p<0.005) and AD (1.20 points annually, HR 2.26, p<0.005).Conclusions: pGFAP and pNfL differed in FTD and AD, their combination could be useful to distinguish the two diseases. pGFAP could also be used to track disease severity and predict greater cognitive decline during follow-up in patients with FTD.
Patent Ductus Arteriosus Device or Surgical Closure: the Role of Charity Missions Where the Resources Are Limited
Authors: Elsheikh Abdallah Elamin , Hassan Salah Eldin M.E , Nureldayim Abdel Mahmoud , Ahmed Mohamed Alamin , Hussein Sabir Taha , allah.Eljack Moh.Mah.Fadel
Published: October 2021

Objectives

To compare the different methods of treatment of patent ductus arteriosus (PDA), and evaluate the role of charity missions in availing the expensive devices for needy patients where the resources are limited.
Background

The role of surgery is gradually being taken over by catheter intervention, however the cost in not affordable to most of our patients. Charity organizations are helping limited resource countries by availing the devices.
Methods

All paediatrics patent ductus arteriosus (PDA) patients presenting to Medani Heart Centre (MHC) in a 6-year period were included in this study. The study included 337 patients. 283 were treated by catheter intervention group (A) and 54 were treated surgically group (B), 22 patients were referred for surgery from the catheterization laboratory, and 32 were treated when there was no visiting teams.
Results

A total of 337 patients were included in this study, 32 were treated surgically by the local surgical teams. Out of remaining 305 patients 283 were found suitable for catheterization intervention, and were treated successfully, 22(%7) were having other congenital anomalies or PDA not suitable for intervention and were referred to surgery. 54 patients were treated by surgical ligation, 22 were referred from the intervention group and 32 were treated surgically when there were no visiting delegates and patients’ condition dictate urgent intervention, with good results. Devices were provided by charity organizations and delivered by the visiting teams, the choice of device depends on the availability.
Conclusions

Surgery remains a good modality of treatment were the resources are scares, however a number of charity organizations are offering these expensive devices for countries of low and middle income making it possible for the poor patients to have such treatment. The results of both treatments are excellent
Aspect ratio is associated with recanalization after coiling of unruptured intracranial aneurysms
Authors: Hara Takeshi , Satow Tetsu , Hamano Eika , Hashimura Naoki , Sumi Masatake , Ikedo Taichi , Ohta Tsuyoshi , Takahashi Jun C , Kataoka Hiroharu
Published: October 2021

Background

The rate of recanalization after coil embolization for unruptured intracranial aneurysms (UIAs) is reported to occur around 11.3-49%. Aim of this study is to investigated the factors that influence the recanalization after coil embolization for unruptured intracranial aneurysms (UIAs) in our institution.
Methods

We retrospectively investigated 307 UIAs in 296 patients treated at our institution between April 2004 and December 2016. The stent used cases were excluded. Cerebral angiography and 3D TOF MRA were used for evaluation of the postoperative occlusion status. Volume embolization ratio (VER), aneurysmal size, neck width, and aspect ratio (AR) were compared between the recanalized and non-recanalized groups.
Results

The mean follow-up period ranged from 6 to 172 months (mean: 79.0±39.8 months). Recanalization was noted in 87 (28.3%) aneurysms, and 19 (6.2%) aneurysms required retreatment. There was no aneurysmal rupture during the follow-up period. Univariate analysis showed that the aneurysm size (p < 0.001), neck width (p = 0.002), AR (p = 0.003), and VER (p = 0.027) were associated with recanalization. Multivariate logistic regression analysis showed that the AR (p =0.004) and VER (p =0.015) were significant predictors of recanalization.
Conclusions

In our study, AR and VER were significant predictors of recanalization after coil embolization for UIAs.
Physiochemical effect on the microgroove microstructure in microcutting of pure copper
Authors: Zhang Jiayi
Published: October 2021

Physiochemical effect on the machining of pure copper is studied via microstructure characterization on the cross-sectioned microgroove. An obvious decreased cutting force and thrust force were obtained with the application of surfactant. The surface roughness of microgroove with physiochemical effect is 12 nm, and that without physiochemical effect is 17 nm. The average grain size of the medium-affected sample is 67.9 µm within the microgroove zone, and that of the medium-free sample is 48.3 µm within the microgroove zone, moreover, the grain size of medium-free microgroove near the microgroove surface is larger than that far away from the microgroove surface. Additionally, the grain orientations of medium-affected cross-sectioned surface present anisotropy, while that of medium-free cross-sectioned surface are towards {101} direction. Based on the calculation and analysis of geometrically necessary dislocation, it can be inferred that the induced stress and temperature in the sample with physiochemical effect are higher than that without physiochemical effect, which can provide enough driving energy for recrystallization.
Using exhalation dynamics to evaluate PEEP levels in COVID-19 related ARDS
Authors: Depta Filip
Published: October 2021

Background

We hypothesized that measured expiratory time constant (TauE) could be a bedside parameter for evaluation of PEEP settings in mechanically ventilated COVID-19 patients during pressure-controlled ventilation (PCV) mode. TauE is an easily measured parameter to assess lung physiology, even in non-homogeneous lungs including COVID-19 ARDS.
Methods

A prospective study was conducted including consecutively admitted adults (n = 16) with COVID-19 related ARDS requiring mechanical ventilation. Ventilator settings for all patients included: PCV, RR 18/min, constant inspiratory pressure 14 cmH2O, I:E ratio 1:1.5 and FiO2 1.0. Escalating levels of PEEP (0 to 18 cmH2O) were applied and measured TauE and expiratory tidal volume (Vte) recorded. Next, a new parameter, TauE Index (TEI) was calculated (TEI = TauE * Vte) at each PEEP level in prone (n = 29) or supine (n = 24) positions. TEI maps were created to graphically show changes in individual physiology with PEEP. The PEEP setting with the highest TEI corresponded to the highest product of TauE and Vte and was considered the most suitable PEEP. Most suitable PEEP range was calculated as ± 10% from highest TEI.
Results

Two groups of patterns were observed in the TEI maps, recruitable (R) (75%) and non-recruitable (NR) (25%). In R group, the most suitable PEEP and PEEP range was 9±3 cmH2O and 6-12 cmH2O for prone position and 11±3 cmH2O and 7-13 cmH2O for supine position. In NR group, the most suitable PEEP and PEEP range was 7±3 cmH2O and 0-8 cmH2O for prone position and 4±2 cmH2O and 0-7 cmH2O for supine position, respectively. The R group showed significantly higher suitable PEEP (p<0.01) and PEEP ranges (p<0.01) than NR group. 45% of measurements resulted in most suitable PEEP being significantly different between the positions (p < 0.01).
Conclusions

Based on TEI mapping, responses to PEEP were easily measured. There was wide variation in patient responses to PEEP that indicate the need for personalized evaluation.
Association between serum uric acid level and carotid atherosclerosis and metabolic syndrome in patients with type 2 diabetes mellitus
Authors: li wei , Wang Yan , Ouyang Shengrong , Li Mengdi , Liu Rui , Zhang Yuqi , Liu Xiaojun , Li Tianfang , Liu Shengyun
Published: October 2021

Background

Serum uric acid (SUA) is associated with many cardiovascular risk factors, such as metabolic syndrome (MetS) and subclinical atherosclerosis. However, the relationship of SUA with carotid atherosclerosis remains controversial. We aimed to investigate whether elevated SUA levels are associated with a high risk of carotid atherosclerosis and MetS in patients with type 2 diabetes mellitus (T2DM).
Methods

This cross-sectional study was performed with a sample of 1,947 hospitalized patients with T2DM. Carotid intima-media thickness (CIMT) and carotid artery plaques (CAP) were measured via Doppler ultrasound.
Results

Uric acid levels were negatively associated with HbA1C, eGFR, and HDL-C (all P < 0.001) and positively associated with WBC, BMI, ACR, creatinine, total cholesterol, triglycerides, LDL-C, systolic blood pressure, and diastolic blood pressure (all P < 0.001). After adjusting for multiple potential confounders, the risks were substantially higher for MetS in the highest quartile of SUA levels (odds ratio: 2.91, 95% confidence interval: 1.54–5.51, P = 0.003 for trend) than in the lowest quartile of SUA levels. Furthermore, a significant increase was observed in the prevalence of overweight/obesity, hypertension, and dyslipidemia across the SUA quartiles independent of confounders. However, no significant association was found between SUA quartile with the presence of carotid atherosclerosis.
Conclusions

In patients with T2DM, SUA levels were closely associated with MetS and its components but not with carotid atherosclerosis.
An Efficient Discrete Wavelet Transform Based Hybrid Image Watermarking Algorithm Using Human Visual Model
Authors: V Sundhararaj , B Meenakshipriya , P Nirmala Devi
Published: October 2021

More than ever with growing of multimedia technology, the digital data are exchanged in the internet, which can be duplicated by unauthorized users. To avoid this problem the watermarking technology has brought this paper. Performance improvement with compare to existing algorithm is obtained by proposing a new watermarking algorithm based on Human Visual Model (HVM) and Discrete Wavelet Transform (DWT) for securing the digital data and copyright protection. DWT is applied to the input image and at each level of DWT sub bands to embed a watermark image in selected coefficients of the sub band. HVM integrate the weight factor effect of human visualization by considering into the eye’s vision is less sensitivity area, depending on brightness, frequency band and texture areas of the image sub band. In the proposed approach robustly and imperceptibly, DWT and HVM are used for obtainable weight factor, according to human eye perceptual and to determine the optimal strength at which the threshold to embedding reaches the perceptual invisibility of watermarked image to various attacks. Performance is evaluated such as Peak Signal to Noise Ratio (PSNR), Structural Similarity Index Measure (SSIM) and Quality Index (QI) is used to evaluate and achieve the imperceptible watermarked image. Results of PSNR values of hybrid image watermarking are between 49.73db to 36.24db. Experimental results show that our hybrid image watermarking process has enhanced robustness and displays the effectiveness of presenting images watermarking system.
Kulturanthropologie als Veränderungswissenschaft
Authors: Faßler † Manfred
Published: October 2021

Es sagt sich so leicht: unsere Welt verändert sich. Was aber verändert sich oder wird verändert? Wodurch, durch wen, warum? Cui bono? Leben wir in einer Welt „kreativer Zufälle“, von denen der Physiker Klaus Mainzer (2007) spricht? Oder lenkt dies vom „Egoismus der Gene“ ab, den der britische Biologe Richard Dawkins (1976) betont. Geschieht oder passiert Veränderung? Wird sie gemacht? Sind ´Egoismen der Kultur´, des Marktes, der Ökonomie daran beteiligt? Woher kommen diese? Welchen Sinn haben sie bei globalen Kooperations- und Konsensanforderungen? Und was ist zu tun, wenn sich herausstellt, dass die Bedingungen umwälzender Veränderungen menschengemacht und brutal und gewaltförmig sind, wie Saskia Sassen in ihrem Buch „Ausgrenzungen“ (2015) beschrieb. Oder, wenn wir uns selbst, unsere Körper, unsere Seinsweisen, unsere Denkweisen absichtlich verändern, wir eine Cyborgisierung (Haraway 1991) betreiben? Muss Wissenschaft dann explizit politisch werden? Sollten die ersten Schritte eine „experimental respecification of sociality with digital technologies“ (Marres & Gerlitz 2019, 3, Anm.1) sein? Mit diesen wenigen Fragen stelle ich verändern und machen in den Vordergrund meines Essays. Der Text ist ein Plädoyer für eine Kulturanthropologie, die sich dem reproduktiven Gattungsverhalten ebenso widmet wie Kultur-, Sozial-, Kommunikations-, Urbanisierungs-praxen, Kreativität, Maschinen- und Technologieentwicklungen.
Stimulating creative behaviors in the work environment: influences of employee engagement, authentic leadership, and human capital factors on employee creativity
Authors: Adekanmbi Foluso , Ukpere Wilfred Isioma
Published: October 2021

This paper investigates employee engagement, authentic leadership and human capital factors’ influences on the creative behaviors of bank employees within Nigeria’s banking industry. This investigation’s sample was taken from a selection of banks (Guarantee Trust Bank Plc, First Bank Plc, and United Bank For Africa Plc) across the Lagos and Ibadan cities of Lagos and Oyo States, Nigeria. This paper adopts a survey study approach, and questionnaires were randomly circulated. However, out of the 300 questionnaires distributed, 273 were fit to be used for the research and analyzed via statistical packages for social sciences (SPSS vs. 26). The current findings suggest that the younger the bank employees, the more creative they are. The higher their educational level and work experience, the more creative they are within Nigeria’s banking industry. The current investigation further established that employee engagement and authentic leadership significantly and positively influence creativity amongst employees within Nigeria’s banking industry. Therefore, the management of the Nigerian banks needs to consider spurring of employees’ sense of belonging and engagement to help stimulate and nurture their creativity. They should also consider essential authentic leadership training for their managers to help them discharge their leadership functions, related to the positive development of their subordinates’ creative behaviors and the human capital factors in stimulating employee creativity.
Directions for improving adaptive management efficiency of manufacturing pharmaceutical companies
Authors: Sahaidak-Nikitiuk Rita , Holybtsova Karyna , Demchenko Nataliya , Nikitiuk Vitalii
Published: October 2021

The aim of the article is to analyze the existing problems of adaptive management of manufacturing pharmaceutical companies and the development of methodological support for their management.

Materials and methods. The research used methods of theoretical generalization, analysis and synthesis, synergetic approach and expert survey.

120 people were involved in the expert survey, divided into four groups: representatives of pharmaceutical manufacturing enterprises (30 people); representatives of pharmaceutical higher education institutions (30 people); pharmaceutical distributors representing wholesale companies (30 people); end users (30 people).

Results. The article considers scientific and methodological approaches to improving adaptive management in the direction of forming competitive advantages of manufacturing pharmaceutical companies, the practical implementation of which requires business entities determination, flexibility and adequacy in the formation of modern management strategies and tactical planning and operational tasks of production, economic and commercial activities. There are external and internal factors influencing the formation of competitive advantages of the business entity. As the internal factors we include: organizational and legal form, and business entity organizational structure; the level of scientific and technical development of production; level of education and qualification of staff; business image of the enterprise; financial reputation of the enterprise. However, no less influence on the formation of competitive advantages of the management of manufacturing pharmaceutical companies have external factors, which, in contrast to internal, are not controlled by the entity: the state of the pharmaceutical market; technologies; workforce; scientific and technical development; etc.

Conclusions. The directions of increasing the adaptive management efficiency are determined and it is concluded that the main criterion of efficiency is the quality of pharmaceutical products and the quality of management decisions in economic risks.
Comparison of the effects of co-transplantation of bone marrow hematopoietic stem cells and thymic multipotent stromal cells on the immune system of mice depending on methods
Authors: Demchenko Dariia , Nikolskiy Igor , Nikolskaya Valentyna , Pelykh Natalia
Published: October 2021

Physical interaction of multipotent stromal cells (MSCs) and hematopoietic stem cells (HSCs) is a modern approach to effective and focused changes in the properties of HSCs. Resulting of those contact interaction is significant activation of cells with following immune system restoration.

The purpose of the study is to investigate the effect of co-transplantation of bone marrow hematopoietic stem cells (HSCs) and thymic multipotent stromal cells (MSCs) separately and as a union of cells on regeneration of the murine immune system, damaged by cyclophosphamide.

MSCs were obtained from thymuses of C57BL mice using explant technique. Bone marrow cells (BMCs) were obtained by flushing out the femur with a nutrient medium. BMCs were cocultivated for 2 hours on the monolayer of thymus-derived MSCs. The immune deficiency of mice was modelled by the treatment with cyclophosphamide (CP). After that, the cells were co-transplanted in two methods (separately into different the retroorbital sinus and as a union after co-cultivation) and the parameters of the immune system were evaluated. It was shown, that separate co-transplantation of BMCs and thymus-derived MSCs is associated with the restoration of the number of bone marrow cells, thymus, spleen and lymph nodes with an increase in the proliferation index of lymph node cells by 1.4 times compared to control. It normalized the previous reduced concentration of hemoglobin and hematocrit in the blood. Co-transplantation had a suppressive effect on the blast transformation reaction, induced by phytohemagglutinin, by 4.3 times, but showed a stimulating effect on DTHR response by 1.6 times compared to control.

Co-transplantation of the union of BMCs and MSCs is associated with the restoration of the number of bone marrow cells, spleen and lymph nodes. The level of spontaneous apoptosis of lymph node cells significantly increased by 3.3 times compared to control. It had not effect on hematological parameters, but is activated to impact the immune system. Thus, as a result of cells union administration showed normalization of the bactericidal activity of peritoneal macrophages, unlike the separate co-transplantation. This cells graft had a suppressive effect on the number of antibody-producing cells in the spleen by 4.2 times compared to control.

Previous co-cultivation and contact interaction of cells change the properties of cell graft. The effect of co-transplantation of BMCs and thymic MSCs is not a simple additive effect of cells. It is acquiring the features typical to certain cell types, and the expression of new characteristics. We assume this phenomenon as a result development of complex cells cooperative processes in vivo and in vitro
Chemical and enzymatic destruction of chondroitin sulfate from Arctic skate
Authors: Kuchina Y. A. , Konovalova I. N. , Novikov V. Y. , Dolgopyatova N. V. , Kuznetsov V. Ya.
Published: October 2021

Due to its biocompatibility with human and animal tissues, low toxicity, and biodegradability, chondroitin sulfate (CS) is of great interest for medicine. Since CS is used as a pharmaceutical preparation, its molecular weight and solubility determine the possibilities of its use. This work presents the results of studying the chemical and enzymatic destruction of CS macromolecules and its effect on the molecular weight, solubility and crystallinity degree of the polysaccharide. CS was obtained from the cartilaginous tissue of the Arctic skate ( Amblyraja hyperborea ). At the stage of cartilage tissue fermentolysis, the enzymes pancreatin, hepatopancreatin and protosubtil were used. The obtained CS samples were identified by IR spectroscopy. Enzymatic destruction of glycosidic bonds in cholesterol macromolecules was carried out with a 1 % solution of the enzyme hepatopancreatin, chemical destruction with hydrogen peroxide and hydrochloric acid. The CS content in the samples was determined by the Dische method. The chemical composition of CS samples was evaluated by standard methods. The average molecular weight (MW) was determined using high performance liquid chromatography and the nephelometric method. The crystallinity degree (CD) was determined by graphical processing of diffraction patterns obtained by X-ray phase analysis of CS samples. It was found that under the action of hepatopancreatin and hydrogen peroxide, deep destruction of chondroitin sulfate occurs, to the formation of low molecular weight and oligomeric fragments. Under conditions of acid destruction in 0.5 N HCl for 20 min the MW of chondroitin sulfate is reduced by 10 % compared to the initial one. Acid destruction causes a significant decrease in the CD of the CS samples. For CS samples not degraded in acid, the solubility in distilled water increases with decreasing MW and CD. The solubility of CS after acid destruction in the range of pH = 5-9 units is 99.0 ± 0.5 %. This high solubility is most likely explained by the significant content of the amorphous phase in the samples.
The study of biotechnological potential of Lactobacillus sakei LSK-103
Authors: Nikiforova A. P. , Khamagaeva I. S.
Published: October 2021

Lactic acid bacteria play an important role in the production of food. Bacterial cultures widely used in the food industry often have a set of characteristics that ensure the stability of the production. The biotechnological properties of Lactobacillus sakei LSK-103 have been studied in the present work. Lactobacillus sakei LSK-103 has shown high biochemical activity on MRS medium. It has been found that after 16 h of cultivation at the end of the exponential growth phase, the number of viable bacterial cells reaches 10 CFU/cm. The study of the effect of different concentrations of sodium chloride on biomass accumulation has shown that Lactobacillus sakei LSK-103 is highly resistant to salt. Increase in NaCl concentration from 2 to 10 % leads to decrease in cell survival from 96.8 to 91.2 %, and in number of bacteria to 10 CFU/cm. Morphological studies indicate that an increase in the concentration of sodium chloride in the medium is accompanied by cell cohesion, the formation of cell conglomerates. Cohesion intensifies intercellular contacts and increases the resistance of Lactobacillus sakei LSK-103 to osmotic stress. The high survival rate of Lactobacillus sakei LSK-103 has been shown in the presence of bile, phenol (0.4 %), high (pH 8.3) and low (pH 3.5) values of active acidity of the medium indicating its probiotic properties. The results of research have shown that the Lactobacillus sakei LSK-103 has high biotechnological potential and can be used as part of bacterial preparations for the production of fermented fish products.
PHYTOCHEMICAL SCREENING AND APHRODISIAC EFFECT OF ETHANOLIC EXTRACT OF MASSULARIA ACUMINATA(G. DON) BULLOCK EX HOYL. (RUBIACEAE)IN MALE WISTAR RATS
Authors:   Department of Biochemistry and Microbiology, Jean Lorougnon Guede University., Gbogbo Moussa , Hugues Olivier N Guessan Alain ,   Laboratory of Bio-Organic Chemistry and Natural Substances (LCBOSN), Nangui Abrogoua University., Kone Mama ,   Laboratory of Physiology, Pharmacology and Pharmacopoeia, Nangui Abrogoua University, 02 BP 801 Abidjan 02, Cote dIvoire., Assom Ahoulou Stanislas ,   Department of Biochemistry and Microbiology, Jean Lorougnon Guede University., Tano-bla Aboli Felicite ,   Department of Biochemistry and Microbiology, Jean Lorougnon Guede University., Angoue Yapo Paul ,   Laboratory of Physiology, Pharmacology and Pharmacopoeia, Nangui Abrogoua University, 02 BP 801 Abidjan 02, Cote dIvoire.
Published: October 2021

Objective: The objective of the present study is to determine, through phytochemical screening, the major chemical compounds and to evaluate the aphrodisiac effect of the ethanolic extract of M.acuminata stems in adult male rats. Methods :To achieve our objectives, a phytochemical study was conducted to determine the major chemical compounds present in the ethanolic extract of M. acuminatastems. The phytochemical screening was carried out following standard analytical procedures using thin layer chromatography.The aphrodisiac effect was evaluated in sexually naÃƒÂƒÃ‚ÂƒÃƒÂ‚Ã‚Â¯ve male rats. In sexually naÃƒÂƒÃ‚ÂƒÃƒÂ‚Ã‚Â¯ve male rats, a single administration of the ethanolic extract was performed at doses of 10, 20 and 40 mg/kg versus 0.5 mL/100g distilled water and 715 ÃƒÂƒÃ‚Â‚ÃƒÂ‚Ã‚Âµg/kg Sildenafil Pfizer 50 mg in the negative and positive control rats, respectively. Female rats were induced to oestrus by sequential administration of estradiol benzoate (Sigma - Aldrich) (25 ÃƒÂƒÃ‚ÂŽÃƒÂ‚Ã‚Â¼g/rat) to make them receptive to males. Results :The results of the phytochemical screening revealed that the ethanolic extract of M. acuminata stems contains coumarins, flavonoids, tannins, triterpenes of triterpenesaponins. The biological study showed that at doses of 20 and 40 mg/kg, ethanolic extract of M. acuminatastems resulted in a significant (p < 0.05) and highly significant (p < 0.001) increase in the number of sexual mounts, the number of erections, the number of ejaculations and a significant (p < 0.01) decrease in the latency time between sexual mounts in male rats. Conclusions:The sexual stimulating effects of the ethanolic extract of M. acuminata observed in this study could be attributed to the presence of the identified chemical compounds, hence the interest in using this plant in traditional aphrodisiac medicine.
PREVALENCE AND RISK FACTORS OF PROSTATITIS LIKE SYMPTOMS AMONG MALES BETWEEN AGE 15-45 YEARS OLD IN TAIF GOVERNORATE, KSA
Authors: Abdelbaky Ayman , Ahmed Asiri Abdulelah , Saad Alqahtani Hussain , Abdulghani Althobaiti Faisal , Abdulmohsen Aljuaid Faisal , Abdullwahed Sirdar Anmar , Muteb Almansori Khaled
Published: October 2021

Background: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is one of the most frequent and mysterious disorder seen in the daily practice of urology, it is a chronic deactivate syndrome composed of pelviperineal pain of vague etiology, frequently accompanied by voiding plus sexual symptoms. Many studies have found multiple different factors rise risk of prostatitis consist of dietary factors, sexual factors, perineal factors, and sedentary lifestyle. Our aim is to assess the prevalence of prostatitis-like symptoms in males between age 15-45 years old in Taif gouvernante and risk factors related to prostatitis. Methodology: cross-sectional study targeting 409 males aged between 15 to 45 years old living in Taif governorate using a predesigned questionnaire, including demographic characteristics, Arabic Version of the National Institutes of Health Chronic Prostatitis Symptom Index, and risk factors of prostatitis. Results: In this study, we collected data from 409 participants, mostly aged between 21-25 years (64.1 %). In general, the mean score of pain, urinary symptoms, and impact of symptoms on QoL were 3.33 (3.75), 2.1 (2.36) and 3.0 (2.71). We found that marital status and smoking status had significant effect on pain score where divorced, widow and single participants had significant lower pain (P=0.008), and smokers had higher pain score. Some lifestyle is related to pain score. Conclusion: we found that participants in Al Taif city reported lower scores of prostatitis related symptoms. Some habits were related with incidence of prostatitis including consuming of alcohol and smoking as well as experience of GIT disorder. The pain score is increased as reported by participants by increasing stress, decrease in physical activity, sitting for long periods, and wear of tight clothes.
COMBATING CHALLENGES TO MANAGE ENDODONTIC PAIN IN DENTAL PRACTICE
Authors:   Associate Professor, School of Dental Sciences, Plot no.32-34, Knowledge Park 3Sharda University, Greater Noida., Kabra Pooja
Published: October 2021

One of the most challenging and difficult task in clinical practice of an endodontist is to manage pain. Advancements in understanding of pain physiology and pharmacology have provided a key upon which quick decisions can be made for treatment of any endodontic case. Despite advancement in technology, patients perception and apprehension is till date considered as a standard to acknowledge the expertise of an endodontist when undergoing a routine endodontic therapy. The current article aims to reflect effective strategies of management of endodontic pain in pre-operative, operative and postoperative situations. In lieu of clinical relevance of this topic in day to day life of an endodontist the topic was also addressed as a scientific paper presentation in a national conference to welcome thoughts of colleagues at a broader platform.
CARACTERISATIONS PHYSICO-CHIMIQUES ET MINERALOGIQUES DE LARGILE DAKLAKOU UTILISEE DANS LA POTERIE EN VUE DE SON APPLICATION DANS LA FORMULATION DES AGREGATS LEGERS
Authors:   Laboratoire GTVD (Gestion Traitement et Valorisation des dechets), Universite de Lome BP 1515 Lome, Togo., Koriko Moursalou , Zounon Dodji ,   Laboratoire GTVD (Gestion Traitement et Valorisation des dechets), Universite de Lome BP 1515 Lome, Togo., Degbe Agbegnigan ,   Laboratoire GTVD (Gestion Traitement et Valorisation des dechets), Universite de Lome BP 1515 Lome, Togo., Tchegueni Sanonka ,   Laboratoire GTVD (Gestion Traitement et Valorisation des dechets), Universite de Lome BP 1515 Lome, Togo., Diheenane Bafai Diyadola ,   Laboratoire GTVD (Gestion Traitement et Valorisation des dechets), Universite de Lome BP 1515 Lome, Togo., Fiaty Koffi ,   Laboratoire dAutomatique, de Genie des Procedes et de Genie Pharmaceutique (LAGEPP), 43 Boulevard du 11 Novembre 1918, Batiment CPE, 69622 Villeurbanne Cedex, Universite Claude Bernard Lyon-1., Tchangbedji Gado ,   Laboratoire GTVD (Gestion Traitement et Valorisation des dechets), Universite de Lome BP 1515 Lome, Togo., Drogui Patrick ,   Centre Eau Terre Environnement de lInstitut National de la Recherche Scientifique (INRS)- ETE, 490 Couronne St, Quebec City, Quebec G1K 9A9, Canada Quebec, Canada.
Published: October 2021

In order to contribute to the enhancement of local materials, Aklakou clays taken from the quarry and used for pottery have been characterized from a physicochemical and mineralogical point of view. Thus, the samples taken from the quarry were subjected to chemical and mineralogical analyzes. Several qualitative and quantitative analysis techniques were used (chemical analysis, thermal analysis, X-ray diffraction and analysis by I.R. spectroscopy). These results demonstrated the richness of this quartz clay, resulting in a high proportion of silica (77.62%). This study was therefore essential before any application of this type of clay in the formulation of aggregates and pottery products or even ceramics in the broad sense. We can therefore conclude that the clays mined at the Aklakou quarry are very favorable materials for formulations of pottery products and in other fields such as the formulation of light aggregates.
AN INSIGHT INTO - HEMIFACIAL MICROSOMIA
Authors: Sahoo Nivedita , Mohanty Rajat , Singh Arpita , Prasad Dash Bhagabati , Singh Dhull Kanika
Published: October 2021

Hemifacial microsomia is a common birth defect involving first and second branchial arch derivatives. The phenotype is highly variable. In addition to craniofacial anomalies, there may be cardiac, vertebral, and central nervous system defects. Most cases are sporadic, but there are rare familial cases that exhibit autosomal dominant inheritance.
DEVELOPMENT OF DENTITION
Authors: Sahoo Nivedita , Mohanty Rajat , Singh Arpita
Published: October 2021

Knowledge of the normal development of the dentition and an ability to detect deviation from the normal are essential prerequisites for orthodontic diagnosis and a treatment plan. Dentition means a set of teeth, teeth in the dental arch are used to designate the natural teeth in position in their alveoli.
Sistem Kehadiran Biometrik Sidik Jari Menggunakan IoT yang Terintegrasi dengan Telegram
Authors: Martulandi Adipta , Setiawan Dedi
Published: October 2021

The rapid development of technology today is very useful for humans in various aspects of life. One of the impacts of these technological developments is IoT (Internet of Things). Currently, IoT has been widely used in various fields such as manufacturing, offices, public transportation, and education. One of the uses of IoT in the field of education is to create a biometric attendance system using fingerprints. The purpose why use the fingerprints is to reduce cheating committed by students such as leaving absent. By using the fingerprint IoT attendance system, this is difficult to do because everyone has a different form of fingerprint. In addition, this project integrates fingerprint attendance with the Telegram messenger application. All fingerprints and student attendance data are stored on the website. Based on the experimental results, the success rate of this attendance system is 80%, and the accuracy is 89%.
Życie synodalne metropolii gnieźnieńskiej oraz diecezji pruskich i frankońskichkońca XIV i pierwszej połowy XV wieku (uwagi na marginesie najnowszych badań) - cz. 1
Authors: Zygner Leszek
Published: October 2021

Przedmiotem niniejszego artykułu są synody metropolii gnieźnieńskiej oraz diecezji pruskich i frankońskich z lat 1378-1449. Z zachowanych źródeł wynika, że w okresie tym odbyło się 71 synodów diecezjalnych, z czego w metropolii gnieźnieńskiej – 43, w diecezjach pruskich – 15 i w diecezjach frankońskich – 13, a także zwołano 17 synodów prowincjonalnych (w metropolii gnieźnieńskiej – 14 i w metropolii ryskiej – 3). Częstotliwość synodów w poszczególnych diecezjach potwierdza, że po okresie pewnego zastoju, który występował od połowy XIV wieku, nastąpiło znaczne ożywienie synodalne w pierwszej połowie XV wieku, a zwłaszcza w okresie trwania soboru w Bazylei, a potem we Florencji i w Rzymie.
An Overview of the Synthetic Route to the Marketed Formulations of Pyrimidine: A Review
Authors: Kumar Amit , Siwach Ankit , Verma Prabhakar
Published: October 2021

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Pyrimidine and its derivatives are a very important class of heterocyclic compounds that
show interesting applications in the field of medicinal chemistry. Pyrimidine not only plays an important
role as an organic reaction intermediate but also has a wide range of interesting biological activities
viz. antibacterial, antifungal, anticancer, anti-inflammatory, antiviral, and antiprotozoal activities,
etc. Numerous methods are available for the formation of pyrimidine derivatives that have been
reported in the literature. The advantage of pyrimidine as a starting material for different therapeutically
potent derivatives has given momentum to this research. This review aims to report the new
work on the synthesis of marketed drugs which consist pyrimidine moiety.
FEATURES OF FORMATION OF PROFESSIONAL COMPETENCE OF FUTURE DOCTORS IN MODERN CONDITIONS
Authors: Kostyshyn А. B. , Ozhogan Z. R. , Kostyshyn Z. Т. , Ilnytska О. М. , Shturmak V. М.
Published: October 2021

IFNMU actively uses educational innovations in various pedagogical processes, determining adequate mechanisms for the transformation of higher education. After all, innovative education is a constant desire to re-evaluate values, preserve those that are of undeniable importance, and discard those that are already outdated.

In the practice of IFNMU, the diversification of educational technologies allows effectively combine them through the modernization of traditional education and its reorientation to distance education. With this approach, teachers focus on the personal development of future professionals, the ability to master new experiences of creative and critical thinking, finding solutions to educational problems. Therefore, we consider the innovative educational technology as a general didactic process, which consists in using a set of methods and techniques of joint activities of the subjects of the educational process aimed at achieving the goal of learning, personality development and creative and professional acquisition of knowledge and competencies in accordance with the tasks of training specialists of modern times.

The process of forming the professional competence of future doctors consists of a set of consistent, purposeful actions that contribute to the renewal, modification of purpose, content, organization, forms and methods of teaching and education, adaptation of the educational process to new socio-historical conditions. Innovations in medical education do not arise spontaneously, but arise as a result of systematic scientific research, analysis, generalization of pedagogical experience. The basis of these processes is the implementation of the achievements of psychological and pedagogical science in practice, study, generalization and dissemination of advanced domestic and foreign pedagogical experience in training doctors.

At the present stage, the integration of knowledge in pedagogical theory is seen as a synthesis of interacting sciences on the basis of some basic discipline. The mechanism of interdisciplinary integration is to implement the explanatory, constructive and prognostic functions of academic disciplines, in their transformation into a methodological, theoretical and technological means of building holistic models of the researched phenomena and processes, solving cognitive and professional problems.

As the practical experience of synchronizing the study of related educational material from different courses has shown, as well as the maximum use of multidisciplinary knowledge to study complex objects and concepts of medicine is an important condition for the effectiveness of the educational process.

Productive integration of knowledge covers such ways as solving interdisciplinary problems, performing complex practical tasks, conducting educational and research observations, conducting lectures and practical classes, applying problem situations in one discipline to classes in another.
Analyzing the biosynthetic potential of antimicrobial-producing actinobacteria originating from Indonesia
Authors: Utami Anissa , Apriliana Pamela , Kusnadi Yudi , Zilda Dewi S. , Ilmiah Zidny , Lisdiyanti Puspita , Setyahadi Siswa , Uria Agustinus R.
Published: October 2021

We investigated the biosynthetic potential of soil-associated actinobacteria originating from Indonesia, identified as Streptomyces luridus and as Streptomyces luteosporeus. Antimicrobial assays indicated inhibitory activity by both strains against the pathogen Pseudomonas aeruginosa, with S. luteosporeus particularly inhibiting the growth of Bacillus subtilis. PCR-amplification, cloning, and sequencing of ketosynthase (KS) domains of type I modular polyketide (PKS-I) and adenylation (AD) domains of non-ribosomal peptide synthetase (NRPS) indicated the diversity of KS and AD domains derived from both Indonesian Streptomyces. Further phylogenetic analysis showed that KS domains from the subclass cis-AT PKS can be classified as being a part of a loading module or an extension module, along with their predicted substrate specificity. The results suggest that both strains are a potential source of novel biosynthetic pathways. This genetic analysis approach can be used as a fast guide to obtain insight into natural product biosynthetic gene diversity in microorganisms.
ANFIBIOS Y REPTILES DE ALUXES ECOPARQUE PALENQUE, CHIAPAS; MÉXICO
Authors: Cabrera Hernández Rodolfo , Toledo González Karina Antonia , Enríquez Robles Dante Iván
Published: October 2021

Se presentan los resultados de un inventario herpetofaunístico realizado en Aluxes Ecoparque Palenque en los meses de enero a febrero y de junio a noviembre del 2017, en donde se realizaron16 eventos de muestreo. Se utilizó la técnica de Inspección por Encuentro Visual por tiempo limitado (2 horas), sobre los principales caminos y senderos existentes en Aluxes Ecoparque Palenque.  Se registró una abundancia de 298 individuos y una riqueza de 43 especies, formada por 16 especies de anfibios (37%) y 27 de reptiles (63%). La curva de acumulación de especies de anfibios y reptiles indica que el inventario está casi completo. De las especies registradas de anfibios y reptiles 12 se encuentran en de las categorías de riego según la NOM-059-SEMARNAT-2010.
CONTRIBUCIÓN AL CONOCIMIENTO DE LA DIETA NATURAL DE LA SERPIENTE MAZACOATL (Boa imperator DAUDIN, 1803) EN VERACRUZ, MÉXICO.
Authors: Vásquez-Cruz Víctor
Published: October 2021

La serpiente Boa imperator es la especie de mayor tamaño en México, es reconocida por su dieta generalista. Presentamos el primer caso documentado de zorra gris (Urocyon cinereargenteus) en la dieta natural de la serpiente mazacoatl (B. imperator).
NEW PREY ITEM IN THE DIET OF Masticophis schotti BAIRD & GIRARD, 1853 FROM SAN LUIS POTOSÍ, MEXICO
Authors: Carbajal-Márquez Rubén Alonso
Published: October 2021

A new prey item is reported in the diet of Masticophis schotti from San Luis Potosí, Mexico. Although lizards of the genus Sceloporus had previously been reported, this is the first record of S. torquatus in the diet of M. schotti.
RECORDS OF Sauromalus ater (DUMÉRIL, 1856) HATCHLINGS AND SUBADULTS ON SAN FRANCISCO ISLAND, GULF OF CALIFORNIA, MÉXICO
Authors: Cerdá-Ardura Adrián
Published: October 2021

Six hatchlings of the Common or Sonoran Desert Chuckwalla (Sauromalus ater) ranging from 60 mm to 93 mm (SVL) as well as 10 subadult individuals (mostly ♀) ranging from 110 mm to 146 mm (SVL) were recorded during three casual walks on the small island San Francisco, Baja California Sur, Gulf of California, México, in January and February, 2019. The presence of these hatchlings and subadult females could be an important sign of chuckwallas’ recovery and of continued population’s recruitment following eradication of feral cats and goats from the island in 1999 and 2000 respectively, and despite the intense presence of humans (fishermen and tourists) on the island. The chuckwalla population seems to be growing and becoming conspicuous on San Francisco after almost two decades of rare and infrequent records of individuals. Also, the vegetation shows more abundance and diversity, and more extensive covering than in previous years. Other vertebrate species, like the Baja California Rattlesnake (Crotalus enyo) and the Burrowing Owl (Athene cunicularia) were recorded as well during the walks. All these observations possibly indicate a whole and progressive biota restoration on this tiny island after devastation by invasive fauna, combined with previous good wet years.
SOBRE EL ESTATUS TAXONÓMICO DE Apostolepis roncadori LEMA, 2016 Y Apostolepis vittata (COPE, 1887) (SERPENTES: DIPSADIDAE)
Authors: Entiauspe-Neto Omar
Published: October 2021

Apostolepis Cope, 1862 is a particularly speciose Dipsadid snake genus; several species are still known from small series of individuals, with most species still lacking basic information on their morphological variation, ecology, systematics, and conservation, which has resulted in a particularly difficult taxonomic history for the group. In this study, i revisit the taxonomic status of the recently described Apostolepis roncadori Lema, 2016, being considered herein as a junior synonym of Apostolepis vittata Cope, 1887, considering that most of the proposed diagnosis to the former species is under overlap with the latter, or can be attributable to intraspecific variation.
Epicrates alvarezi (ÁBALOS, BAEZ & NADER, 1964) (SQUAMATA: BOIDAE)
Authors: Pardo Maximiliano , Olivieri Bornand Samuel Ernesto , Pérez Iglesias Juan Manuel
Published: October 2021

Documentamos el primer registro de Epicrates alvarezi en la provincia de San Luis, Argentina. Esta boa arcoiris ha sido categorizada como amenazada por lo que los especimenes hallados aportan valiosa información para la conservación de la fauna chaqueña. Estos registros además extienden la distribución conocida para la especie aproximadamente 85 km al sur-oeste del Chaco Seco, siendo los registros más austales y occidentales para la especie.
NUEVOS REGISTROS DE Craugastor yucatanensis (ANURA: CRAUGASTORIDAE) EN EL ESTADO DE YUCATÁN
Authors: Nahuat Cervera Pedro Enrique
Published: October 2021

En esta nota se presentan dos nuevas localidades de registro de Craugastor yucatanensis, siendo las más septentrionales en la Península de Yucatán y aportando información para completar un vacío distribucional entre los dos registros más cercanos.
Amerotyphlops microstomus (SQUAMATA: TYPHLOPIDAE)
Authors: Nahuat Cervera Pedro Enrique
Published: October 2021

En este escrito se presenta una nueva localidad de la serpiente ciega yucateca Amerotyphlops microstomus (Cope, 1866) en el municipio de Dzemul, Yucatán, México, siendo el registro más septentrional para esta especie e incrementando su rango de distribución 32. 4 km del registro más cercano.