bluuebunny/crossref_metadata_2025 huggingface dataset:
Sirt5 is dispensable for BrafV600E‐mediated cutaneous melanoma development and growth in vivo
Authors: Moon Hyeongsun , Zhu Jerry , White Andrew C.
Published: November 2018

Sirt5 is known to functionally regulate mitochondrial proteins by altering posttranslational modifications, including lysine desuccinylation. While roles for Sirt5 as either a tumor promoter or suppressor, or in chemoresistance, have been implicated in other cancers, the function of Sirt5 in cutaneous melanoma has not been well examined. Therefore, to determine whether Sirt5 is necessary for BrafV600E‐mediated melanoma formation and/or disease progression, we crossed a genetically engineered murine melanoma model (TyrCreERT2/+; BrafLSL‐V600E/+; Ptenflox/flox) to Sirt5−/− knockout animals. In addition, we tested for synergism with a selective BRAF (V600E) inhibitor in Sirt5−/− mouse melanoma cells. Taken together, this report demonstrates that, in these models, Sirt5 is dispensable for BrafV600E‐mediated cutaneous melanoma formation and growth in vivo, and does not improve sensitivity to a selective BRAF inhibitor.
Intravenous single administration of amiodarone and breastfeeding
Authors: Javot Lucie , Pape Elise , Yéléhé‐Okouma Mélissa , Barotte Emilie , Divoux Emmanuelle , Gillet Pierre , Gambier Nicolas , Scala‐Bertola Julien
Published: November 2018

Amiodarone treatment is contraindicated during breastfeeding. As the regional pharmacovigilance centre, we were contacted for information relative to the possibility of breastfeeding after single intravenous administration of 450 mg amiodarone to a breastfeeding woman. A monitoring of amiodarone concentration in plasma and milk was performed in the mother. At day 4, milk concentration of amiodarone reached a peak (233 μg/L) and milk to plasma ratio was determined to 3.5. Milk concentration was still detectable at day 10 (132 μg/L). The maximal relative infant dose was estimated to be 0.6% of the maternal weight‐adjusted dosage, corresponding to 0.18% of the usual posology used in children by parenteral route. The review of the literature retrieved one publication suggesting that a single intravenous administration of 150 mg of amiodarone to a mother represents a negligible infant risk based on low breast milk concentration. The French National Pharmacovigilance database query did not disclose any case of side effects during breastfeeding after a single dose of amiodarone. A very limited exposition of breastfed newborns to amiodarone, as well as a low risk of side effects, is expected after a single administration of amiodarone to their mothers.
Is there an association between indoor allergens and the severity of atopic dermatitis?
Authors: Cid Barbara J. , Perez‐Mateluna Guillermo , Iturriaga Carolina , Zambrano María J. , Vives María I. , Valenzuela Patricia M. , Borzutzky Arturo
Published: November 2018

Background

Atopic dermatitis (AD) is a multifactorial inflammatory skin disease with frequent hypersensitivity to allergens. However, the role of exposure to indoor allergens on AD severity is unclear.

Methods

Children aged 0–17 years with active AD from central Chile were recruited; disease severity was evaluated with SCORAD and POEM scores. A home environment survey was applied to parents. Bedroom dust samples were collected for all subjects and analyzed by multiplex assay to quantify dust mite (Der p1, Der f1), dog (Can f1), cat (Fel d1), and alternaria alternata (Alt a1) allergens.

Results

Twenty‐five children aged 3.9 ± 3.8 years were included. Fifty‐two percent were female. Mean SCORAD was 29 ± 14 (range 11–61), and mean POEM was 10.7 ± 6.2. No direct association was found between tobacco exposure, pet ownership, aerosol use, visible dust, or home carpets/rugs with SCORAD (all P > 0.05). Dust samples from all homes had Can f1 and Fel d1 allergens, regardless of pet ownership. Homes that had indoor dogs or cats had significantly higher amounts of these allergens (P < 0.001). Forty percent of homes had dust mite allergens, and none had alternaria alternata. Children with AD living in homes with elevated dust mite and animal dander allergen concentrations had higher SCORAD than those from homes with low allergen concentrations (40 ± 13 vs. 26 ± 13, P = 0.025).

Conclusions

High concentrations of indoor allergens may influence AD severity in children. Further studies assessing indoor allergens and allergen sensitization are warranted to fully evaluate the role of indoor allergens on AD.
Subclinical atherosclerosis in psoriatic disease: relation to endocan, TNF‐α, age of onset, and body fat
Authors: Elkamshoushi Abdelaal M. , Omar Salma S. , El Abd Amr M. , Hassan Seham Z. , Sultan Eman A. , Abd Elkawy Eman
Published: November 2018

Background

Psoriasis is a common multisystem inflammatory disease with several associated comorbidities. Serological markers to detect associated subclinical atherosclerosis in psoriatic patients are needed. We aimed to study serum endocan levels in psoriasis vulgaris and its relation to severity of psoriasis, systemic inflammation, associated atherosclerosis, obesity, and the possible factors affecting its level in psoriatic patients.

Methods

This study was conducted on 30 moderate‐severe psoriasis vulgaris patients and 30 healthy controls. Body mass index, body fat percent, and PASI assessments were done. Serum endocan and tumor necrosis factor‐α levels were measured by ELISA. Carotid artery intima‐media thickness measurement by high‐resolution ultrasound was performed.

Results

Psoriasis patients showed significantly higher serum tumor necrosis factor‐α and endocan levels (P1 = 0.008, P2 = 0.003). Additionally, there was a statistically significant difference between mean carotid artery intima‐media thickness of both groups (P = 0.005). Serum endocan levels positively correlated with PASI score (P = 0.002), tumor necrosis factor‐α levels (P < 0.001), mean carotid artery intima‐media thickness (P = 0.001), and body mass index (P < 0.001) in the patients group. Additionally, the age of onset of disease negatively correlated with serum endocan (P = 0.003).

Conclusion

Serum endocan is a promising marker of severity of psoriasis and associated atherosclerosis. Early onset psoriasis is associated with higher serum endocan levels. Body mass index is positively correlated with serum endocan levels. The positive correlation of endocan and tumor necrosis factor‐α supports the regulatory effect of the cytokine on endocan production and suggests the role of endocan as an inflammatory marker.
Aerogel‐like ceramic foams with super‐high porosity and nanoscale cell wall from sol nanoparticles stabilized foams
Authors: Huo Wenlong , Zhang Xiaoyan , Hou Shiyu , Chen Yugu , Wang Yali , Yang Jinlong
Published: November 2018

Ultralight ceramic foam materials with high porosity play an important role in increasingly hi‐tech areas due to the combinative merit of ceramic material and highly porous structure. So far, it remains challenging to fabricate alumina ceramic foams with extremely high porosity and high specific surface area that are comparable to aerogel materials by employing a low cost, eco‐friendly and convenient approach. For the first time, we propose the preparation of aerogel‐like ceramic foams with nanoscale cell wall and unprecedentedly high porosity using boehmite sol as both ceramic source and bubble interface stabilizer, based on sol nanoparticles stabilized foams using sodium lauryl sulfate (SDS) as modifier. The obtained ultra‐stable sol foams allow for the achievement of bulk foams with ultrathin cell wall with thickness in the range of 30‐90 nm, super‐high porosity up to 99%, and large specific surface area of 280 m2/g, which is attributed to the well‐organized assembly of nanoparticles at the liquid/air interfaces. This novel foam material demonstrates excellent adsorption ability for polar volatile organic gases (VOCs) due to its extremely high porosity and large specific surface area.
Range expansion ofLymantria dispar dispar(L.) (Lepidoptera: Erebidae) along its north‐western margin in North America despite low predicted climatic suitability
Authors: Streifel Marissa A. , Tobin Patrick C. , Kees Aubree M. , Aukema Brian H.
Published: November 2018

Aim

The European gypsy moth,Lymantria dispar dispar(L.), (Lepidoptera: Erebidae) is an invasive defoliator that has been expanding its range in North America following its introduction in 1869. Here, we investigate recent range expansion into a region previously predicted to be climatically unsuitable. We examine whether winter severity is correlated with summer trap captures of male moths at the landscape scale, and quantify overwintering egg survivorship along a northern boundary of the invasion edge.

Location

Northern Minnesota,USA.

Methods

Several winter severity metrics were defined using daily temperature data from 17 weather stations across the study area. These metrics were used to explore associations with male gypsy moth monitoring data (2004–2014). Laboratory‐reared egg masses were deployed to field locations each fall for 2 years in a 2 × 2 factorial design (north/south aspect × below/above snow line) to reflect microclimate variation. Rates of successful egg hatch were assessed the following springs.

Results

Reductions in summer male moth captures are associated with several metrics of winter severity, such as minimum temperatures. Most egg masses suffered >95% mortality each winter. However, hatching success reached up to 80% in egg masses that had overwintered below the snow line (e.g., <30 cm from the ground).

Main Conclusions

Our findings that cold winter temperatures are associated with reduced summer trap captures of European gypsy moth, likely due to increased overwintering mortality of exposed egg masses, are consistent with previous predictions of thermal range boundaries for this species. However, high survival in egg masses deposited close to the ground are consistent with thermal escape in subnivean environs (i.e., below snow cover), and suggest that further northward range expansion will be likely in areas that receive measurable annual snowfall.
Effect of Age on Opioid Prescribing, Overdose, and Mortality in Massachusetts, 2011 to 2015
Authors: Rose Adam J. , McBain Ryan , Schuler Megan S. , LaRochelle Marc R. , Ganz David A. , Kilambi Vikram , Stein Bradley D. , Bernson Dana , Chui Kenneth Kwan Ho , Land Thomas , Walley Alexander Y. , Stopka Thomas J.
Published: November 2018

Objectives

To examine the effect of age on the likelihood of PIP of opioids and the effect of PIP on adverse outcomes.

Design

Retrospective cohort study.

Setting

Data from multiple state agencies in Massachusetts from 2011 to 2015.

Participants

Adult Massachusetts residents (N=3,078,163) who received at least one prescription opioid during the study period; approximately half (1,589,365) aged 50 and older.

Measurements

We measured exposure to 5 types of PIP: high‐dose opioids, coprescription with benzodiazepines, multiple opioid prescribers, multiple opioid pharmacies, and continuous opioid therapy without a pain diagnosis. We examined 3 adverse outcomes: nonfatal opioid overdose, fatal opioid overdose, and all‐cause mortality.

Results

The rate of any PIP increased with age, from 2% of individuals age 18 to 29 to 14% of those aged 50 and older. Older adults also had higher rates of exposure to 2 or more different types of PIP (40–49, 2.5%; 50–69, 5%; ≥70, 4%). Of covariates assessed, older age was the greatest predictor of PIP. In analyses stratified according to age, any PIP and specific types of PIP were associated with nonfatal overdose, fatal overdose, and all‐cause mortality in younger and older adults.

Conclusion

Older adults are more likely to be exposed to PIP, which increases their risk of adverse events. Strategies to reduce exposure to PIP and to improve outcomes in those already exposed will be instrumental to addressing the opioid crisis in older adults. J Am Geriatr Soc 67:128–132, 2019.
Risk of Mortality in Individuals with Hip Fracture and Traumatic Brain Injury
Authors: Albrecht Jennifer S. , Al Kibria Gulam , Gruber‐Baldini Ann , Magaziner Jay
Published: November 2018

Objectives

To estimate the prevalence of diagnosed traumatic brain injury (TBI) in individuals hospitalized with hip fracture and examine its association with all‐cause mortality.

Design

Nested cohort study.

Setting

National sample of Medicare beneficiaries from 2006 to 2010.

Participants

Beneficiaries aged 65 and older hospitalized with hip fracture.

Measurements

TBI at the time of hip fracture was defined using International Classification of Diseases, Ninth Revision, Clinical Modification codes. The main outcome was all‐cause mortality during follow‐up.

Results

Prevalence of TBI in individuals with hip fracture was 2.7%. Absolute risk of mortality attributable to TBI in individuals with hip fracture was 15/100 person‐years. TBI was significantly associated with risk of death in multivariable analysis (hazard ratio=1.24, 95% confidence interval=1.14–1.35).

Conclusion

TBI was associated with greater risk of mortality in individuals with hip fracture. Practitioners should consider evaluating for presence of TBI in this vulnerable population. J Am Geriatr Soc 67:124–127, 2019.
The influence of crop rotation on the onset of early blight (Alternaria solani)
Authors: Abuley Isaac K. , Nielsen Bent J. , Hansen Hans H.
Published: November 2018

Field experiments were carried out in 2016 and 2017 to determine the effect of crop rotation on the onset of early blight in three potato varieties in Denmark. Six and seven fields with different histories with potato (rotation‐fields) were used for the experiments in 2016 and 2017, respectively. The results showed that variety and the interaction between variety and rotation‐field had no significant effect on the onset of early blight. Rotation‐field, on the other hand, had a significant effect on the onset of early blight in both years of the study. Early blight occurred earlier in fields with <2 years between subsequent potato crops than in fields where potatoes have not been grown for at least 2 years. The onset of early blight was not different between the fields where there had not been potatoes for at least 2 years. For fields that were preceded by potatoes, early blight occurred earlier in fields in which the severity of early blight in the previous years was higher than that in the fields in which the severity of early blight in the previous years was low or moderate. In conclusion, the results of this study suggest that at least a 2‐year interval between subsequent potatoes in a rotation cycle is necessary to delay the onset of early blight. Moreover, the severity of early blight in the previous years can affect the onset of early blight.
Carbon balance and source‐sink metabolic changes in winter wheat exposed to high night‐time temperature
Authors: Impa Somayanda M. , Sunoj V.S. John , Krassovskaya Inga , Bheemanahalli Raju , Obata Toshihiro , Jagadish S.V. Krishna
Published: November 2018

Carbon loss under high night‐time temperature (HNT) leads to significant reduction in wheat yield. Growth chamber studies were carried out using six winter wheat genotypes, to unravel postheading HNT (23°C)–induced alterations in carbon balance, source‐sink metabolic changes, yield, and yield‐related traits compared with control (15°C) conditions. Four of the six tested genotypes recorded a significant increase in night respiration after 4 days of HNT exposure, with all the cultivars regulating carbon loss and demonstrating different degree of acclimation to extended HNT exposure. Metabolite profiling indicated carbohydrate metabolism in spikes and activation of the TriCarboxylic Acid (TCA) cycle in leaves as important pathways operating under HNT exposure. A significant increase in sugars, sugar‐alcohols, and phosphate in spikes of the tolerant genotype (Tascosa) indicated osmolytes and membrane protective mechanisms acting against HNT damage. Enhanced night respiration under HNT resulted in higher accumulation of TCA cycle intermediates like isocitrate and fumarate in leaves of the susceptible genotype (TX86A5606). Lower grain number due to lesser productive spikes and reduced grain weight due to shorter grain‐filling duration determined HNT‐induced yield loss in winter wheat. Traits and mechanisms identified will help catalyze the development of physiological and metabolic markers for breeding HNT‐tolerant wheat.
Conifer tree plantations for land rehabilitation: an ecological‐functional evaluation
Authors: Peláez‐Silva Jorge Alejandro , León‐Peláez Juan Diego , Lema‐Tapias Alvaro
Published: November 2018

Plantations of exotic fast‐growing tree species have been widely used for maintaining or restoring ecosystem functions. Despite this, in tropical countries with high biodiversity, these plantations have been the subject of heated debate. We evaluated the long‐term effect of coniferous tree plantations (Cupressus lusitanica, Pinus patula, Pinus elliottii) on the ecological rehabilitation of the Andean highlands in Colombia. To determine degree of rehabilitation, we assessed whether there were differences in the structure or density of native understory vegetation or soil ecological properties between plots established within tree plantations and plots established within other vegetation cover types (secondary forests, ferns, pastures, and abandoned mining areas). Measured variables were combined to create an index of ecological rehabilitation (ERI). We found significant differences in the ERI values among vegetation cover types: secondary forest (11.78) > conifer plantations (P. elliottii: 6.23, P. patula: 5.33, C. lusitanica: 5.24) > ferns (4.16) > pasture (2.50) > abandoned mining areas (0.43). The results obtained showed that, from the structure of native understory vegetation and soil ecological properties, conifer plantations favored the rehabilitation process. However, among them, it was highlighted that the P. elliotii plantations showed significant differences in the density of native understory species, their values being 1.7 and 2.1 times higher than those corresponding to P. patula and C. lusitanica, respectively. Thus, unlike these plantations that could represent an ecological barrier over time, P. elliottii plantations have enabled the advancement of natural succession, showing a high diversity of native species.
Factors that Influence Proficiency Attainment in a College Language Program: A German Case Study
Authors: Heidrich Emily , Kraemer Angelika
Published: November 2018

As an internal expansion of the Language Proficiency Flagship Initiative at Michigan State University, 172 students of German took ACTFL proficiency tests in three modalities (speaking, listening, and reading) over the course of three years. The test scores and background survey data were analyzed to determine proficiency levels of students at the end of years two and four within the four‐year German program. Several factors that may influence proficiency were identified: students with a declared major, those who were taking the language for professional purposes, and those who had studied abroad showed an increase in proficiency. On the other hand, students who indicated they were taking the language to complete a requirement had a lower average proficiency level. Implications for the curriculum and classroom are discussed.
Szenarien im berufsorientierten Fremdsprachenunterricht: Planung, Unterrichtseinsatz, Assessment und Evaluation
Authors: Kuhn Christina
Published: November 2018

Am Ende von Unterrichtseinheiten eingesetzt, können Szenarien Übungsinhalte verbinden und einzelne Sprachhandlungen zu kommunikativen Handlungsabläufen erweitern. Sie eröffnen nicht nur vielfältige Möglichkeiten, mündliche und schriftliche Kompetenzen zu trainieren und im Fremdsprachenunterricht so anzuwenden, wie es die kommunikative Realität erfordert. Szenarien können auch zur Lernfortschrittsmessung und Evaluation eingesetzt werden und bieten Ansätze zur kompetenzorientierten Gestaltung von Prüfungen, wie an ausgewählten Beispielen gezeigt wird.
The Na+/H+ exchanger NHE1 localizes as clusters to cryptic lamellipodia and accelerates collective epithelial cell migration
Authors: Jensen Helene H. , Pedersen Gitte A. , Morgen Jeanette J. , Parsons Maddy , Pedersen Stine F. , Nejsum Lene N.
Published: November 2018

Key points

Exogenous Na+/H+ exchanger 1 (NHE1) expression stimulated the collective migration of epithelial cell sheets

Stimulation with epidermal growth factor, a key morphogen, primarily increased migration of the front row of cells, whereas NHE1 increased that of submarginal cell rows, and the two stimuli were additive

Accordingly, NHE1 localized not only to the leading edges of leader cells, but also in cryptic lamellipodia in submarginal cell rows

NHE1 expression disrupted the morphology of epithelial cell sheets and three‐dimensional cysts

Collective cell migration plays essential roles in embryonic development, in normal epithelial repair processes, and in many diseases including cancer. The Na+/H+ exchanger 1 (NHE1, SLC9A1) is an important regulator of motility in many cells and has been widely studied for its roles in cancer, although its possible role in collective migration of normal epithelial cells has remained unresolved. In the present study, we show that NHE1 expression in MDCK‐II kidney epithelial cells accelerated collective cell migration. NHE1 localized to the leading edges of leader cells, as well as to cryptic lamellipodia in submarginal cell rows. Epidermal growth factor, a kidney morphogen, increased displacement of the front row of collectively migrating cells and reduced the number of migration fingers. NHE1 expression increased the number of migration fingers and increased displacement of submarginal cell rows, resulting in additive effects of NHE1 and epidermal growth factor. Finally, NHE1 expression resulted in disorganized development of MDCK‐II cell cysts. Thus, NHE1 contributes to collective migration and epithelial morphogenesis, suggesting roles for the transporter in embryonic and early postnatal development.
Ultrathin ZSM-5 zeolite nanosheet laminated membrane for high-flux desalination of concentrated brines
Authors: Cao Zishu , Zeng Shixuan , Xu Zhi , Arvanitis Antonios , Yang Shaowei , Gu Xuehong , Dong Junhang
Published: November 2018

We synthesized nanometer-thick ZSM-5 nanosheets to form laminated thin membranes for enhanced desalination of concentrated brines.
Isolated hip fracture in the elderly and time to surgery: is there an outcome difference?
Authors: Elkbuli Adel , Eily Alyssa , Polcz Valerie , Boneva Dessy , Spano II Paul J , McKenney Mark , Hai Shaikh
Published: November 2018

Background

Early operative intervention for hip fractures in the elderly is advised to reduce mortality and morbidity. Postoperative complications impose a significant burden on patient outcomes and cost of medical care. Our aim was to determine the relationship between time to surgery and postoperative complications/mortality in patients with hip fracture.

Methods

This is a retrospective review of data collected from our institution’s trauma registry for patients ≥65 years old with isolated hip fracture and subsequent surgery from 2015 to 2017. Patients were stratified into two groups based on time to surgery after admission: group 1: <48 hours versus group 2: >48 hours. Demographic variables included age, gender, race, and Injury Severity Score (ISS). The outcome variables included intensive care unit length of stay (ICU-LOS), deep venous thrombosis (DVT), pulmonary embolism (PE) rate, mortality, and 30-day readmission rates. Analysis of variance was used for analysis, with significance defined as a p value <0.05.

Results

A total of 485 patients with isolated hip fracture required surgical intervention. Of those, 460 had surgery <48 hours and 25 had surgery >48 hours postadmission. The average ISS was the same in both groups. The average ICU-LOS was significantly higher in the >48 hours group compared with the <48 hours group (4.0 vs. 2.0, p<0.0002). There was no statistically significant difference between groups when comparing DVTand PE rate, 30-day readmission, or mortality rates.

Discussion

Time to surgery may affect overall ICU-LOS in patients with hip fracture requiring surgical intervention. Time to surgery does not affect complication rates, 30-day readmission, or mortality. Future research should investigate long-term outcomes such as functional status and disability-adjusted life years.

Level of evidence

III. Retrospective/ prognostic cohort study
Discurso e Identidade: múltiplos enfoques
Authors:   Universidade de São Paulo. Faculdade de Filosofia, Letras e Ciências Humanas, Gonçalves-Segundo Paulo Roberto , Pedro Adriana Moreira ,   Universidade de São Paulo. Faculdade de Filosofia, Letras e Ciências Humanas, Oliveira Agildo Santos Silva de ,   Universidade de São Paulo. Faculdade de Filosofia, Letras e Ciências Humanas, Silva Alexandre Marques ,   Universidade de São Paulo. Faculdade de Filosofia, Letras e Ciências Humanas, Sousa Douglas Rabelo de ,   Universidade de São Paulo. Faculdade de Filosofia, Letras e Ciências Humanas, Costa Letícia Fernandes de Britto ,   Universidade de São Paulo. Faculdade de Filosofia, Letras e Ciências Humanas, Kobayashi Sergio Mikio ,   Universidade de São Paulo. Faculdade de Filosofia, Letras e Ciências Humanas
Published: November 2018

O livro “Discurso e Identidade: múltiplos enfoques” reúne um conjunto de vinte artigos – aprovados em avaliação cega por pares – de docentes e de alunos de todos os níveis de pesquisa acadêmica (Iniciação Científica, Mestrado e Doutorado) orientados ao debate das relações entre identidade, discurso e linguagem. Os estudos contemporâneos sobre identidade apontam que ela é constituída a partir de um jogo entre subjetividade e alteridade, o que permite sua aproximação tanto com pesquisas voltadas à interação e ao discurso quanto com estudos ligados à história, à estrutura social, às práticas socioculturais e aos processos psicológicos e cognitivos que embasam sua construção, vista como dinâmica, heteróclita, processual, contraditória. Nos artigos publicados neste livro, os autores mobilizam diferentes arcabouços teórico-metodológicos para uma discussão atualizada sobre o tema, como a Análise do Discurso de linha francesa, a Análise Crítica do Discurso, a Análise Dialógica do Discurso, a Teoria da Argumentação, a Semiótica, a Pragmática, a Análise da Conversação, a Sociolinguística Interacional, a Linguística Funcionalista, a Linguística Cognitiva e a Linguística Aplicada.
Parathyroid carcinoma: case report
Authors: Silva Matheus Henrique de Freitas , Morais Pedro Otávio de Resende , Souza Thaís Andrade de , Muniz André Luis Ribeiro , Silva Bárbara C , Noviello Thiago Bechara , Andrade Marcella Menezes
Published: November 2018

Parathyroid carcinoma (PC) is an uncommon pathology which has propaedeutic and therapeutic peculiarities. In general, it presents as symptomatic primary hyperparathyroidism, that corresponds to only 1% in this subgroup. Both the clinical and histological diagnosis of PC are difficult due to inconsistent criteria. Laboratorial exams commonly present hypercalcemia and PTH well-above the reference value. Surgery is the only curative and effective treatment for parathyroid carcinoma. Case report: Patient M.P.R.L., 48 years old, female, melanodermic, native and from Felisburgo - MG. The disease had been progressing for 2 years with progressive weakness, anemia, renal dysfunction, chronic pain and weight loss (about 15 kg in last five months), associated with PTH-dependent hypercalcemia and renal function decline. A cervical study showed the presence of two thyroid nodules whereas a parathyroid scintigraphy showed no evidence of glands hyperplasia or adenoma. She was admitted to the Santa Casa Hospital of Belo Horizonte for a propaedeutic and therapeutic management of the presented profile.
Resenha de 'Eclipse da Razão', de Max Horkheimer [trad. de Carlos Henrique Pissardo]
Authors: Lima Bruna Della Torre de Carvalho , Santos Eduardo Altheman Camargo
Published: November 2018

Referência completa: Horkheimer, Max. Eclipse da Razão. Trad. Carlos Henrique Pissardo. São Paulo: EditoraUnesp, 2015.
Mudanças culturais e simbólicas que abalam o Brasil
Authors: Ridenti Marcelo Siqueira
Published: November 2018

Apesar de envolver toda a sociedade, a dinâmica social e política da crise por que passa a democracia brasileira é dada pelas lutas sociais que mobilizam as classes médias escolarizadas. Um forte indício nesse sentido está na composição social das manifestações de rua a partir de 2013 e outros dados analisados no artigo, como o acesso crescente ao ensino superior, resultado de mudanças culturais e simbólicas nos últimos anos, sem que tenham ocorrido transformações estruturais. Essas mudanças ajudam a compreender a polarização política em curso que ameaça a democracia.
Inevitável e imprevisível, o fortalecimento da direita para além da dicotomia ação e estrutura
Authors: Carlotto Maria Caramez
Published: November 2018

O presente artigo parte de uma reconstrução do debate teórico sobre a ascensão da direita conservadora, marcado pelas dicotomias ação/estrutura, local/global e política/economia, para defender uma abordagem que pense a articulação entre essas dimensões através de um olhar estrutural para as novas modalidades de mobilização e circulação internacional de elites locais. Através dessa operação, eu procuro mostrar como essas novas modalidades de atuação internacional ajudam a constituir uma nova posição no espaço de produção e difusão de conhecimento, na figura dos Think Tanks. No entrecruzamento de lógicas distintas, os Think Tanks passam a disputar espaço com as instituições de ensino superior, em particular as universidades públicas de pesquisa, que viveram um processo de democratização a partir dos anos 2000, período que coincide, justamente, com a crescente expansão e legitimação dos Think Tanks na América Latina. Assim, procuro mostrar como essas novas modalidades de atuação do internacional só podem ser compreendidas estruturalmente à luz das hierarquias sociais que constituem a formação de elites intelectuais nessas sociedades nacionais.
Palestra: Intelectuais, mídias e universidade pública em contexto de peleja
Authors: Miceli Sergio
Published: November 2018

A palestra de Sergio Miceli trata da relevância que a imprensa escrita, televisiva e demais agentes e meios comerciais tomaram ao longo do tempo no Brasil. Segundo o seu diagnóstico, eles passaram a disputar a hegemonia intelectual com o setor tradicionalmente produtor de conhecimento: a universidade. Isso posto, cabe fazer uma reflexão sobre o papel do intelectual na universidade e a busca por soluções nessa guerra simbólica.
Resenha de 'Direita, volver!: o retorno da direita e o ciclo político brasileiro', de Sebastião Velasco e Cruz, André Kaysel e Gustavo Codas (Orgs.)
Authors: Niemietz César
Published: November 2018

Referência completa: Velasco e Cruz, Sebastião; Kaysel, André; Codas, Gustavo (Orgs.) Direita, volver!: o retorno da direita e o ciclo político brasileiro. São Paulo: Editora Fundação Perseu Abramo, 2015, 304 p.
Filologia e Crítica Textual
Authors: Campos Maria Inês Batista , Santiago-Almeida Manoel Mourivaldo
Published: November 2018

Com esse tema, o leitor é convidado à reflexão advinda de estudos sobre a transmissão do texto escrito de variados domínios discursivos que, necessariamente, envolve o processo de edição ou reprodução ou estabelecimento ou fixação desses textos. Por sua vez, a depender dos critérios utilizados por quem os edita e publica, pode conduzir a leituras ou interpretações desafinadas (para mais ou para menos) com as possíveis leituras ou interpretações que poderiam e podem ser realizadas a partir da versão mais afinada do texto deixado pelo seu autor.
National Socialism as a Doctrine of Rancour (1937)
Authors: ter Braak Menno
Published: November 2018

This essay by the Dutch modernist writer Menno ter Braak, ‘National Socialism as a Doctrine of Rancour’, was written in 1937 just before the German annexation of the Netherlands. It is a rare examination of how the concept ressentiment can be used to analyse 1930s National Socialism, outlining the ways in which the fascist variant of ressentiment is both distinctive and also, nonetheless, connected to its democratic and socialist versions. The essay develops Nietzsche’s and Scheler’s understandings of ressentiment by applying them to fascism, insisting on the centrality of the moral sentiment of ressentiment not just to populism but to all forms of democracy, and to any philosophical or political orientation committed to an ideal of equality, indeed to all of modern society, culture and politics.
The Relation Between Teacher Vocabulary Use in Play and Child Vocabulary Outcomes
Authors: McLeod Ragan H. , Kaiser Ann P. , Hardy Jessica K.
Published: November 2018

Although extensive research exists on vocabulary instruction during book reading in preschool classroom, comparatively little research has been conducted on vocabulary exposure in classroom play contexts and child vocabulary outcomes. The purpose of this study was to examine Head Start teacher and child vocabulary use in dyadic play sessions and the relation between teachers’ vocabulary use and children’s vocabulary outcomes. One Enhanced Milieu Teaching (EMT) session for each of 53 teacher–child dyads was transcribed and coded for teacher use of target and sophisticated vocabulary, use of teacher strategies to support vocabulary development, and child use of vocabulary. Descriptive data indicate variability for both teacher and child vocabulary use in the play sessions. Both teacher total number of vocabulary words and vocabulary supports were significantly related to child vocabulary use within sessions. Implications for practice are discussed.
Manufacturing service order allocation in the context of social manufacturing based on Stackelberg game
Authors: Guo Wei , Jiang Pingyu
Published: November 2018

For adapting the socialization, individuation and servitization in manufacturing industry, a new manufacturing paradigm called social manufacturing has received a lot of attention. Social manufacturing can be seen as a network that enterprises with socialized resources self-organized into communities that provide personalized machining and service capabilities to customers. Since a community of social manufacturing has multiple enterprises and emphasizes on the importance of service, manufacturing service order allocation must be studied from the new perspective considering objectives on service cost and quality of service. The manufacturing service order allocation can be seen as a one-to-many game model with multi-objective. In this article, a Stackelberg game model is proposed to tackle the manufacturing service order allocation problem with considering the payoffs on cost and quality of service. Since this Stackelberg game can be mapped to a multi-objective bi-level programming, a modified multi-objective hierarchical Bird Swarm Algorithm is used to find the Nash equilibrium of the game. Finally, a case from a professional printing firm is analyzed to validate the proposed methodology and model. The objective of this research is to find the Nash equilibrium on the manufacturing service order allocation and provide strategies guidance for customer and small- and medium-sized enterprises with optimal service cost and lead time. According to the game process and Nash equilibrium, some rules are revealed, and they are useful for guiding practical production.
Free vibration analysis of composite laminated and sandwich plate with circular cutout
Authors: Hachemi M , Hamza-Cherif SM
Published: November 2018

This paper presents the free vibration analysis of a composite laminated and sandwich square plate with circular cutout. The problem formulation is based on the higher order shear deformation plate theory HDST C0 coupled with a curved quadrilateral p-element. The elements of the stiffness and mass matrices are calculated analytically. The curved edges are accurately represented using the blending function method. A calculation program is developed to determine the fundamental frequencies for different physical and mechanical parameters such as the cutout size and location, plate thickness, fiber orientation angle and boundary conditions. The results obtained show a good agreement with the available solutions in the literature. New results for the fundamentals frequencies of composite laminated and sandwich plates with circular cutout are presented.
State-of-the-art review on Bayesian inference in structural system identification and damage assessment
Authors: Huang Yong , Shao Changsong , Wu Biao , Beck James L. , Li Hui
Published: November 2018

Bayesian inference provides a powerful approach to system identification and damage assessment for structures. The application of Bayesian method is motivated by the fact that inverse problems in structural engineering, including structural health monitoring, are typically ill-conditioned and ill-posed when using noisy incomplete data because of various sources of modeling uncertainties. One should not just search for a single “optimal” value for the vector of model parameters but rather attempt to describe the whole family of plausible model parameters based on measured data using a Bayesian probabilistic framework. In this article, the fundamental principles of Bayesian analysis and computation are summarized; then a review is given of recent state-of-the-art practices of Bayesian inference in system identification and damage assessment for civil infrastructure. Discussions of the benefits and deficiencies of these approaches, as well as potentially useful avenues for future studies, are also provided. Our focus is on meeting challenges that arise from system identification and damage assessment for the civil infrastructure but our presented theories also have a considerably broader applicability for inverse problems in science and technology.
Comparative evaluation of CacyBP/SIP protein, β-catenin, and immunoproteasome subunit LMP7 in the heart of rats with hypertension of different etiology
Authors: Kasacka Irena , Piotrowska Żaneta , Weresa Jolanta , Filipek Anna
Published: November 2018

Calcyclin-binding protein/Siah-1-interacting protein (CacyBP/SIP) is the recently discovered peptide, which participates in various intracellular processes. Recent reports indicated that CacyBP/SIP activates the ubiquitin ligases and promotes proteasomal degradation of proteins. One of the most important proteins degraded in CacyBP/SIP-dependent pathway is β-catenin. Considering the key importance of β-catenin in the functioning of the cardiovascular system and in the view of the close relationship between CacyBP/SIP, β-catenin, and proteasomal activity, we have decided to undertake research to identify and evaluate the distribution of CacyBP/SIP, β-catenin and the LMP7 subunit of the immunoproteasome in the heart of rats with hypertension of various etiology. The studies were carried out on the hearts of rats with spontaneous hypertension (SHR), renovascular hypertension, and DOCA-salt hypertension. The myocardial expression of CacyBP/SIP, β-catenin, and LMP7 was detected by immunohistochemistry using the EnVision method. The hypertension significantly increased the immunoreactivity to CacyBP/SIP and LMP-7, while weakening the β-catenin immunoreaction. The intensity of the observed changes depends on the type of hypertension. Our results show an innovative and important network of interactions between proteins potentially involved in the development and progression of heart problems in various types of hypertension. This report might contribute to deeper understanding of the role of the CacyBP/SIP protein, β-catenin, and immunoproteasomes in heart function, as well as to bringing new information concerning pathophysiologic mechanisms leading to cardiac dysfunction in the state of elevated blood pressure.

Impact statement

Despite extensive research into the pathogenesis of hypertension and disease-related end organ damage, the mechanisms leading to cardiac complications of hypertensive patients are still not fully elucidated. The aim of the presented research was immunodetection and evaluation of CacyBP/SIP, β-catenin, and proteasomes in the hearts of rats with hypertension of different etiology. Our results show an innovative and important network of interactions between proteins potentially involved in the development and progression of heart problems in various types of hypertension. This report might contribute to deeper understanding of the role of the CacyBP/SIP protein, β-catenin, and proteasomes in heart function. Our results might also bring new information concerning the intracellular processes and signal pathways involved in the regulation of cardiomyocytes functioning in hypertension state. In addition to cognitive significance, the results of presented studies may contribute to further successes in preventing and treatment of cardiac complications associated with hypertension.
Brain-derived neurotrophic factor in peripheral blood mononuclear cells and stroke outcome
Authors: Pedard Martin , Brenière Céline , Pernet Nicolas , Vergely Catherine , Béjot Yannick , Marie Christine
Published: November 2018

Stroke outcome is dependent on brain-derived neurotrophic factor (BDNF)-dependent neuroplasticity. As peripheral blood mononuclear cells (PBMC) contain BDNF, diapedesis of these cells might be followed by BDNF delivery to the ischemic brain. To test this hypothesis, we investigated the association between BDNF levels in PBMC and functional outcome in patients with ischemic stroke. BDNF was measured in PBMC that were isolated from ischemic stroke patients ( n = 40) just before (day 0) and after (days 1 and 3) fibrinolysis. Three months after stroke, patients were stratified using the modified Rankin Scale (mRS) according to the unfavorable (mRS scores 3–6) and favorable (mRS scores 0–2) functional outcome. We used univariate and multivariate logistic regressions to assess the relationship between BDNF levels in PBMC and functional outcome. BDNF levels in PBMC decreased from day 0 to day 3 in patients with unfavorable outcome, while they remained stable in patients with favorable outcome. Patients with favorable outcome exhibited at day 3 higher PBMC-BDNF levels than patients with unfavorable outcome and the levels were associated with good outcome (odd ratio: 12.0; 95% confidence interval, 1.4–106.2, P = 0.023). PBMC-BDNF levels remained a predictor of stroke outcome after adjusting from cardiovascular risk, interval between admission and fibrinolysis, stroke severity from hospital admission to discharge, lymphocytes count, neutrophils/lymphocytes ratio at admission. Favorable functional outcome in ischemic stroke patients that benefited from fibrinolysis was predicted by a high BDNF level in PBMC, suggesting that PBMC might serve as a cellular vector to deliver BDNF to the ischemic brain.

Impact statement

There are a great number of arguments suggesting that BDNF could be involved in stroke recovery dependent of neuroplasticity. Methods that can enhance BDNF levels in the ischemic brain could therefore have great clinical value. Peripheral blood mononuclear cells (PBMC) that contain BDNF and infiltrate early and sustainably the ischemic brain might be used as a cellular vector to deliver BDNF to the ischemic brain and consequently promote recovery. This work is important in this field to show if this BDNF derived from BDNF could exert a positive action on stroke recovery. Our main results showed that a high BDNF level at day 3 after hospital admission was associated with a 12.4 fold increase in favorable outcome after adjusting for still recognized prognostic markers. The new information in this field is this finding identifies PBMC as an attractive cellular vector to deliver BDNF to the ischemic brain.
Bulk density and bulk modulus of adsorbed coalbed methane
Authors: Zou Guangui , Zeng Hu , Peng Suping , Zhou Xiaoyu , Satibekova Sandugash
Published: November 2018

The bulk density and bulk modulus of adsorbed coalbed methane are required to calculate the undrained bulk and shear moduli as well as the fluid-saturated density of the coal reservoir. We derived the formula for the bulk modulus and bulk density of adsorbed methane using the Langmuir equation for isothermal adsorption. The bulk density of adsorbed methane is positively correlated with the gas pressure and Langmuir volume, but it is negatively correlated with the Langmuir pressure and adsorbed methane saturation. The bulk density of adsorbed methane is greater than that of free-state methane for the same gas pressure. The bulk modulus of adsorbed methane is positively correlated with the gas pressure and negatively correlated with the Langmuir pressure; it is much larger than that of free methane, but it is still much smaller than that of water within the normal gas pressure range. Coal samples from the study area demonstrate that the water saturation is less than 95%. Considering adsorbed methane as a pseudosolid, calculations yield a very small difference in the bulk modulus of coal under room-dry conditions. Considering adsorbed methane as a gas, calculations based on spatially uniform or patchy saturation indicate that multiphase fluid saturation produces a very small difference in the elastic parameters and wave velocity of the fluid-saturated coal from the dual-phase fluid (water and free methane).
Early Life Trauma Predicts Affective Phenomenology and the Effects are Partly Mediated by Staging Coupled with Lowered Lipid-Associated Antioxidant Defences
Authors: Maes Michael , Congio Ana , Moraes Juliana Brum , Bonifacio Kamila Landucci , Barbosa Decio Sabbatini , Vargas Heber Odebrecht , Morris Gerwyn , Puri Basant K. , Michelin Ana Paula , Nunes Sandra Odebrecht Vargas
Published: November 2018

Background

Early life trauma (ELT) may drive mood disorder phenomenology, nitro-oxidative pathways and impairments in semantic memory. There are no data regarding the impact of ELT on affective phenomenology and whether these pathways are mediated by staging or lowered lipid-associated antioxidant defences.

Methods

This study examined healthy controls (n=54) and patients with affective disorders including major depression, bipolar disorder and anxiety disorders (n=118). ELT was assessed using the Child Trauma Questionnaire. In addition, we measured affective phenomenology and assayed advanced oxidation protein products; malondialdehyde, paraoxonase 1 (CMPAase) activity, high-sensitivity C-reactive protein (hsCRP), and high-density lipoprotein (HDL) cholesterol.

Results

ELT was associated into with increased risk for mood and comorbid anxiety disorders and a more severe phenomenology, including staging characteristics, depression and anxiety severity, suicidal behaviours, type of treatments, disabilities, body mass index, smoking behaviour and hsCRP, as well as lowered health-related quality of life, antioxidant defences and semantic memory. The number of mood episodes and CMPAase/HDL-cholesterol levels could be reliably combined into a new vulnerability staging-biomarker index, which mediates in part the effects of ELT on affective phenomenology and oxidative stress. Moreover, the effects of female sex on mood disorders and affective phenomenology are mediated by ELT.

Discussion

The cumulative effects of different ELT drive many aspects of affective phenomenology either directly or indirectly through effects of staging and/or lipid–associated antioxidant defences. The results show that children, especially girls, with ELT are at great risk to develop mood disorders and more severe phenotypes of affective disorders.