bluuebunny/crossref_metadata_2025 huggingface dataset:
BRCA mutations: what are the implications for women with ovarian cancer and their families? (Preprint)
Authors: Gaba Fortis , Fernando Dilini , Gaba Qassi Q.
Published: April 2022

UNSTRUCTURED

Individuals carrying BRCA mutations are at a higher risk of developing ovarian cancer. Determining the BRCA status of ovarian cancer has important therapeutic and prognostic repercussions. Importantly, it provides information that can guide predictive genetic testing and risk-reducing interventions; combining these strategies, has proven to be a cost-effective method of treatment. This article highlights the implications of BRCA mutations in women and their families and features the importance for genetic testing in national health care organisations.
State of the Mobile Apps Owned by the Large Pediatric Hospitals in the U.S.: A Review of Google Play and Apple App Stores (Preprint)
Authors: Lieser Tyler , Sezgin Emre , Huang Yungui
Published: April 2022

BACKGROUND

Pediatric hospitals around the United States are increasingly leveraging patient facing mobile apps as their digital front doors for patients, families, and caretakers. These mobile health apps are sanctioned by pediatric hospitals to inform the public or populations about pediatric care, to provide individualized information, to enhance communication, and to improve patient experience. Yet, the design, functionalities, and user feedback of these hospital mobile apps have not been systematically investigated.

OBJECTIVE

Our aim is to understand the current state of hospital-owned mobile apps provided by large pediatric hospitals, comparatively analyze, and report the services provided, and identify potential gaps to inform developers and providers.

METHODS

We conducted a systematic search on Google Play and Apple App Store platforms to identify all hospital-owned mobile apps from the pediatric hospitals included in our review. Specialty apps centered around specific clinical departments, research, procedures, or conditions were excluded. Features and functionality of included apps were examined.

RESULTS

Of the 16 pediatric hospitals included in our review, 4 had no general patient facing apps, 4 had one app, and 8 had more than one app available on Google Play or Apple App Store. The 12 hospitals with at least one mobile app had a combined total of 73 apps. 62 of these apps were considered specialty and were excluded from our review, leaving a total of 11 apps to analyze. The most common feature among apps was appointment scheduling/reminder (82%). Doctor search (73%) and patient resources (73%) were the second most common, followed by payment/billing/claims (64%), patient portal integration (55%), personal health management (55%), hospital wayfinding (45%), message a provider (36%), urgent care wait times (36%), video chat (36%), health information access (36%). Parking information (27%) was the least common.

CONCLUSIONS

Out of 16 pediatric hospitals identified for our review, 75% offer mobile apps. Based on the most common features, these apps were designed to help improve accessibility for patients and families in terms of finding providers, scheduling appointments, and accessing patient resources. We believe the findings will inform pediatric hospital administrators, developers, and other stakeholders to improve app feature offerings and to increase their impact on service accessibility and patient experience.
A Machine Learning Approach for Continuous Mining of Non-identifiable Smartphone Data to Create a Novel Digital Biomarker Detecting Generalized Anxiety Disorder: A Feasibility Study (Preprint)
Authors: Choudhary Soumya , Thomas Nikita , Alshamrani Sultan , Srinivasan Girish , Ellenberger Janine , Nawaz Usman , Cohen Roy
Published: April 2022

BACKGROUND

Anxiety is one of the leading causes of mental health disability around the world. Currently, a majority of the population who experience anxiety go undiagnosed or untreated. New and innovative ways of diagnosing and monitoring anxiety have emerged using smartphone sensor-based monitoring as a metric for the management of anxiety. This is a novel study as it adds to the field of research through the use of non-identifiable smartphone usage to help detect and monitor anxiety remotely and in a continuous and passive manner.

OBJECTIVE

The aim of this study is to demonstrate the feasibility of a daily mental health
behavioural profiling metric called Mental Health Similarity Score for anxiety
generated by mining non-identifiable smartphone data.

METHODS

Smartphone data and self-reported 7-item GAD anxiety assessments were collected from 229 participants on the Android operating system in an observational study over an average of 14 days (SD=29.8). 34 features were mined to be constructed as a potential digital phenotyping marker from continuous smartphone usage data. We further analyzed the correlation of these digital behavioral markers against each item of the GAD-7 and its influence on the machine learning algorithms predictions.

RESULTS

A total of 229 participants were recruited in this study that had completed the GAD-7 assessment and had at least one set of passive digital data collected within a 24-hour period. The mean GAD-7 score was 11.8 (SD=5.7). Regression modeling was tested against classification modeling and the highest prediction accuracy was achieved from a binary Random Forest classification model (Precision 89-92%; Recall 85-94%; F188-91%; accuracy 90%; AUC 96%). Non-parametric permutation testing with Pearson correlation results indicated the proposed metric (MHSS) had the strongest relationship between GAD-7 items 1,3, and 7.

CONCLUSIONS

The proposed Mental Health Similarity Score (MHSS) metric demonstrates the feasibility of using passive non- intrusive smartphone data and machine learning-based data mining techniques to track an individual’s daily anxiety levels with a 90% accuracy that directly related to the Generalized Anxiety Disorder-7 scale.
Морфометрический анализ тканевых структур слизистой оболочки десен крыс под действием инфракрасного лазерного излучения
Authors:   South Ural State Medical University, Department of Pathological Anatomy and Forensic Medicine, Giniatullin Ravil U. , Melnikova Elena R. ,   Set of dental clinics of Vita Smile LLC, Chelyabinsk, Russian Federation
Published: April 2022

The aim of the study — was a comparative study of the adaptive responses of tissue structures and gelatinases of the gingival mucosa (SOD) in healthy rats to the effect of different modes of low-intensity laser radiation (NILI) in the infrared range. Materials and methods of research: the work was performed on 55 laboratory mature female rats using histological, immunohistochemical, zymographic, morphometric and statistical methods. The results of the study: the obtained data confirm the development of biological effects in response to the action of NILI: absorption of photon energy by intracellular components стим stimulation of adaptation reactions: increased activity of enzymes and TC function, activation of microcirculation. Conclusions: 1. After 1 minute and on the 1st day after exposure to NILI with a wavelength of 970 nm and a power of 0.5 W, a more significant increase in the number of TC with VEGFR1 expression, degranulated forms of TC, including with the 1st, 2nd and 3rd degrees of degranulation, the number, diameter of blood vessels and the area occupied by them, and an increase in gelatinase activity was recorded up to 5 days compared to similar indicators at the specified periods after exposure to NILI with a wavelength of 890 nm and a capacity of 25 MW. 2. The presence of a direct strong correlation between the parameters of TC, blood vessels and the activity of gelatinases indicates the development of interrelated physiological processes of adaptation in SOD tissues in response to the action of various parameters of the NILI infrared range. 3. The immunohistochemical method allows for specific detection, precise localization, and objective morphometric analysis of TC with VEGFR1 expression in SOD of control and experimental rats.
Immunohistochemical features of mucinous borderline ovarian tumor. Clinical case analysis
Authors:   Kirov State Medical University of the Ministry of Health of Russia, Gozman Elena S.
Published: April 2022

To describe the immunohistochemical features and the histological picture of mucinous borderline ovarian tumor, to determine their significance for the diagnosis. Materials and methods. The patient’s medical history was analyzed, as well as the results of histological and immunohistochemical studies on histological preparations of postoperative material — a removed ovarian tumor. Results. In the micropreparation of the cyst of the right ovary, sections of the formation of the ovary are presented, the proliferating epithelium of the mucinous type is determined, the atypia of the cell nuclei, the activity of mitosis are determined, there are papillary growths, branching glandular structures, there are areas of deposition of psammological bodies. No invasion of the organ stroma was found. This histological picture corresponds to a mucinous borderline tumor of the ovary. Due to the complexity and diversity of the histological structure of ovarian tumors, an immunohistochemical study is used for the final confirmation of the diagnosis. Immunohistochemical study of postoperative material was carried out using antibodies WT-1, p53, Napsin A, ER, PR, PAX8, CK7, CK20, CDX2, Ki-67. Conclusions. On the example of this clinical case, the immunohistochemical features of a mucinous borderline ovarian tumor were established. Accordingly, the diagnosis of mucinous borderline ovarian tumor was confirmed.
Gender characteristics of perception of additional respiratory resistance
Authors:   Ryazan Statе Mеdical Univеrsity, Russian Federation, Byalovsky Yury. Yu. , Rakitina Irina S. ,   Ryazan Statе Mеdical Univеrsity, Russian Federation
Published: April 2022

When studying a number of respiratory diseases, it was noted that they have a different effect on the perception of respiratory effort and the assessment of the value of the additional respiratory resistance that occurs in men and women. The aim of the study was to study gender characteristics in the subjective assessment of different values of additional respiratory resistance. Methodology. We studied practically healthy subjects (34 men and 28 women), the average age of the subjects was 23.3±2.6 years. Additional respiratory resistance increased stepwise in gradations: 40; 60; 70; 80% of the maximum intraoral pressure (Pmmax). The breathing time with each gradation of resistance was limited to 5 minutes. Resistance tolerance was assessed using the Borg dyspnea visual analogue scale. Before and after stress testing, the subjects underwent situational psychological testing: FPS-2T (V.I. Chirkov’s test), SAN (V.A. Doskin’s test). During stress testing, the subjects were recorded the partial pressure of oxygen and carbon dioxide of the alveolar air (PAO2, PACO2); alveolar ventilation (VA); work of breathing (W); airway resistance (Raw). Results. Gender differences were found in the subjective assessment of different values of additional respiratory resistance. Women showed a lower tolerance time for additional respiratory resistance than men. Breathing under conditions of additional respiratory resistance in women is characterized by less work of the respiratory muscles compared to men. When breathing in conditions of additional respiratory resistance, women experienced a higher level of dyspnea on the Borg scale than men on the same resistance values. The process of overcoming additional respiratory resistance was characterized by a number of situational psychological determinants, namely, higher values of the level of well-being, mood, wakefulness, motivation and a sense of the achieved success in men relative to those in women. Conclusion. An increase in the intensity of resistive loads leads to an increase in the affective component of respiratory sensations. The affective component of respiratory sensations is greater in women than in men.
A Study on Investment Pattern of General Public
Authors: Saranya Ms. B. M. , Joyce Dr. S.
Published: April 2022

Abstract: Investment is the use of finances with the goal of generating extra income and increasing the value of the asset. The Indian economy is booming, and there are numerous investment opportunities. Understanding individual investor behaviour could be extremely useful in explaining stock market oddities, as well as assisting policymakers and researchers in responding to varying investor behaviour. The current study is part of a larger investigation of the elements that influence the general public's investment patterns. This paper examines how different classes of people invest. The study will go through the investment patterns of working women, households, rural people, and salaried employees, as well as the investment patterns of the general public (a diverse category of people). Keywords: Investment pattern, investment avenues, class of people.
ANALISIS FAKTOR YANG MEMPENGARUHI PROFITABILITAS (ROA) BANK SYARIAH DI INDONESIA TAHUN 2014-2018
Authors: Ramadhanty Rizky , Soelistyo Aris
Published: April 2022

Syariah banks is that implement syariah principle in Indonesian. Has introduced banking instutions using syaria system can be a alternative choice for muslim communities in Indonesian. In Indonesia, syariah banks have begun to develop since the issue of law No. 7 year 1992 on banking. As institutions that are important role banks need to pay attention to their performance to operate properly. Performance levels can be assessed using one of the profitability indicators that is Return On Asset (ROA). ROA is a description of the bank’s productivity in managing its funds to get the overall profit. There are indicators related to ROA analysis such as FRD, CAR, BOPO. The purpose of this research is to know the influence of FDR, CAR, BOPO on the profitability of ROA on syariah banks in Indonesian. The method used is multiple regression. Data is processed through e-views. The number of samples used is 13 syariah banks. The result showed the fDR signicantly negative effect on ROA with a coefficient value of -3.77E and a probability of 0.019, CAR has a significant positive effect on ROA with a coefficient value of 0.205 and a value of probability 0.0004, BOPO has a significant negative effect with a coefficient negative effect with a coefficient value of -0.106 and a probability of 0.000. FDR, CAR, BOPO is a simultan effect on ROA.
PENGARUH JUMLAH USAHA DAN INVESTASI TERHADAP JUMLAH TENAGA KERJA INDUSTRI MENENGAH KOTA SURABAYA
Authors: Saleh Fahad Ainun , Soelistyo Aris , Kusuma Hendra
Published: April 2022

This study aims to determine the effect of the number mid-industrial and investment to the labor of mid-industrial in Surabaya during the period 2017-2019. This study used panel data regression with common effect method (CEM). The data used in this research is secondary data. The variables dependent used in this study is the number of labor in Surabaya, while the independent variable are number mid-industrial and investment mid-industrial of Surabaya. Panel data regression calculation results in this study indicate that a variable number mid-industrial and investment simultaneously have a positive influence and significant impact on labor mid-industrial in Surabaya. Partially, variable number mid-industrial and investment have a positive influence and significant impact on labor mid-industrial in Surabaya.
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI KINERJA KEUANGAN BANK UMUM SWASTA NASIONAL DEVISA DI BEI PERIODE 2014-2018
Authors: Seran Trifonia Klara , Nuraini Ida , Boedirochminarni Arfida
Published: April 2022

The purpose of this study is to analyze the influence of Capital Adequacy Ratio (CAR), Non Performing Loans (NPL), Operational Costs to Operating Income (BOPO), Loan to Deposit Ratio (LDR) and Net Interest Margin (NIM) on profitability measured by Return On Asset (ROA) of National private foreign exchange bank in BEI. The analytical tool used is a combined panel data regression analysis method between the time series data of 2014-2018 and cross-section data  6 National private foreign exchange bank in BEI by using the Common Effects model. The results showed that the CAR had a positive and not significant effect on bank profitability (ROA), NPL had a positive and significant effect on bank profitability (ROA), BOPO had a negative effect and significant to bank profitability (ROA), LDR has negative and not significant effect on bank profitability (ROA)and NIM has a positive and not significant effect on bank profitability (ROA).  value of 0.98 (98%) which means as much as 98% changes in bank profitability can be explained by the independent variables that exist while 2% is explained by other causes outside the research model.
ANALISIS PENGARUH SUKUK TERHADAP PEMBIAYAAN PEMBANGUNAN INFRASTRUKTUR DI INDOENSIA TAHUN 2014 – 2018
Authors: Abitaha Arif Pangestu , Soelistyo Aris
Published: April 2022

Infrastructure is one of the important values to support economic growth and development in a country. Inadequate infrastructure will hinder the country's progress and competition compared to other countries. One of the breakthrough sources of financing funds is the use of sharia bonds or what is known as Sukuk. Infrastructure financing through the issuance of Sukuk has been implemented since 2010 with the Project-Based Sukuk (PBS) series. The Indonesian Hajj Fund Sukuk (SDHI), Retail Sukuk (SR), and Project Base Sukuk (PBS) are three of the parts contained in the Sukuk. The purpose of this research is to provide an overview of the development of SDHI, SR, and PBS in financing infrastructure development in Indonesia. By looking at the level of the problem of public goods or can be called public facilities owned by the State.
ANALISIS PENGARUH PENGELUARAN PEMERINTAH DAN INVESTASI TERHADAP PRODUK DOMESTIK REGIONAL BRUTO DI JAWA TIMUR PERIODE 2015-2019
Authors: Wikaningrum Tikaloka , Soelistyo Aris
Published: April 2022

This study researched the effect of government spending and investment on Gross Regional Domestic Product in East Java in 2015-2019. This research uses quantitative research. The data analysis method used was panel data regression with 30 research objects in districts/cities in East Java. This method is a combination of cross-section and time-series sourced from East Java BPS 2015-2019. The results of this study indicate that government spending variables have a significant positive effect on the Gross Regional Domestic Product. The investment variable has a significant negative effect both individually and simultaneously on the Gross Regional Domestic Product. Meanwhile, government expenditure and investment variables together have a significant effect on the Gross Regional Domestic Product in East Java.
Nano-formulations: Recent Trends for Ocular Bioavailability Enhancement
Authors: Chaudhary Roobal , Mishra Ravinesh
Published: April 2022

Eye is a critical part of the body that is readily available and with damage having direct effects on the life of an individual. Delivery of ocular drugs always remain challenging for healthcare professionals and scientists all over the world due to the challenges that dynamic opthalamic environment provides. These challenges involves different barriers like corneal epithelium, corneal stroma, sclera and other bio-membranes (static barriers), choroidal or conjunctival blood flow, lymphatic clearance, tear turnover (dynamic barriers) and efflux pumps/enzymes(metabolic barriers).Ocular diseases include various diseases affecting different parts of the eye. The eye presents comprehensive perspectives and difficulties in the distribution of medicaments, primarily due to the exceptional ability inherent in this mechanism for drugs to enter the main circulatory system and also for eye barrier limitations. Even if conventional non-invasive and invasive treatments like eye drops, injectable preparations and implantable devices are available but these treatments either have bioavailability issues or serious adverse eye effects. Additionally, the new concept of nanoscience and nano-technology gives new a pathway for treating ocular disease. Different active molecules were engineered to communicate with nano-carriers to pass these eye barriers and interact closely with unique specific eye tissues. This study highlights the latest advances in nano-formulations for ophthalmic diagnosis and provides discussions in the mainstream of opthalamic diseases about the role of nano-formulations in nearby future.

Keywords: ocular diseases, nano-technology, static barrier, dynamic barrier, nano-carriers, bioavailability.
Little Known Aspects of Aquatic Insects: Myiasis
Authors: Gökçe Didem
Published: April 2022

Among invertebrates, Diptera, an aquatic insect, has the largest group of species. Aquatic Diptera larvae live in a highly distinctive environment in contact with vertebrates, humans, contaminated water, and depositing eggs in the host organism due to their life cycle. This study aims to describe various aspects of Clogmia albipunctata one of myiasis insects causing a disease that affects both living and dead vertebrates as well as humans and whose symptoms are often overlooked. Furthermore, the study is remarkable since it is the first report of C. albipunctata (Psychodidae) in an indoor drainage system, except for humans, vertebrates, and natural ecosystems. SEM images gave a detailed description of the larvae and confirmed the species identification. When their life cycles were investigated, it was determined that in addition to myiasis, C. albipunctata larvae (drain fly or moth fly) played a vital role in the movement of bacteria from drains to indoor places, such as toilets, bathrooms, showers, and kitchens. Multi-drug resistant bacteria populate C. albipunctata, which possesses synanthropic behavior, and may play a major role in its transmission. This study focused on accidental myiasis.
Students’ perception towards IFAMA agribusiness case study competition: do culture, discipline, and training experience matter?
Authors: Zhu Zhanguo , Tsai Chung-Chou , Wang Yue
Published: April 2022

Case study competition is an effective tool used in higher educational institutions to augment students’ learning experience. Although many studies have explored this phenomenon in business and management discipline, no study has been conducted in agribusiness yet. The current research is conducted to explore students’ perceptions towards agribusiness case study based on cognitive ability, affective ability and development ability. It further explores how cultural difference, students’ discipline, and training experience influence participants’ perceived benefits. Using online survey and a face-to-face interview, it selected 65 participants who had the experience of the agribusiness case study competition. According to students perception, it is apparent that culture had shown main effect in all aspects, while discipline only made a significant difference in development ability. The qualitative analysis unveiled that students preferred to be trained by advisors belonging to field of agricultural economics and management, and are enthusiastic to deal with the real business world issues, and also hold experience of past competitions. Based on these findings, this study may provide guidelines to educators and organizers to improve the case study method of learning and teaching, and efficiently planned the strategies required for competition.
Two cases of low-prostate-specific antigen localized prostate cancer incidentally detected by computed tomography
Authors: Bilim Vladimir , Watanabe Azuma , Horigome Ryoko , Ito Susumu , Hoshi Senji
Published: April 2022

Serum prostate-specific antigen (PSA) plays an important role in the
screening and diagnosis of prostate cancer (PCa). The recommended PSA
cut-off in PCa screening is 4ng/ml. We report two cases of low PSA
localized PCa which were incidentally found by computed tomography (CT)
taken for another disease.
Visualization of Distributed Temperature Sensing shows fine-scale water temperature dynamics in a subarctic stream over melt season
Authors: Croghan Danny , Khamis Kieran , Hannah David , Martinkauppi Ilkka , Ala-Aho Pertti , Marttila Hannu
Published: April 2022

As far as I can tell, no abstract is necessary for HPEye submissions
Research on Analyzing Grassland Runoff and Simulating Grassland Erosion
Authors: Wang Dongdong
Published: April 2022

Grassland runoff is related to soil and water conservation, but there
are few related studies. In this study, a simulated rainfall experiment
was carried out, and the results showed that: 1) The runoff depth
increases with the increase of rainfall intensity and decreases with the
increase of slope or cover, all of which can be described by linear
equations; 2). Soil specific gravity, root fractal dimension and grass
dry weight can explain 5.00%, 31.08%, and 6.64%, respectively;3). The
NSE of the grassland erosion model established by rain intensity, flow
discharge and cover is 0.700, which is 0.142 larger than that of the
grassland erosion model established by rain intensity and flow
discharge.The research conclusions will help prevent and control floods,
improve water resource utilization and strengthen grassland erosion
monitoring.
To King or Not to King: A Canonical-Historical Approach to Ruth
Authors: MOORE MICHAEL S.
Published: April 2022

Contemporary approaches to Ruth tend to focus on the book's internal structure and contents. Only rarely is sufficient attention given to the book's external context, particularly its canonical-historical context. In Judges 17–21 all of the major characters balk in the face of challenge. Priests, landowners, husbands, wives, and warriors all abandon their responsibilities. In Ruth, however, the main characters valiantly shoulder their responsibilities, however burdensome. In Judges, men treat women insensitively, shamefully, even violently. In Ruth, women are treated like partners on a common mission. Why? Having been led by the book of Judges (particularly the self-contained anthology incorporating chaps. 17–21) to wonder whether the one-and-only source of Israel's agony is kinglessness, Ruth is a canonical-historical surprise. Both Ruth 1–4 and Judges 17–21 come from the premonarchical period of the "judges," yet each offers a radically different response to this fluid situation. To read Ruth against its canonical-historical context not only reconnects us with some of the book's earliest interpreters, it also generates newer literary and sociological insights into the theological message of this beloved short story.
Structure and Interpretation in Hebrews 8:1–10:18: A Symphony in Three Movements
Authors: COCKERILL GARETH LEE
Published: April 2022

Most scholars agree that Heb 8:1–10:18 is the author's exposition of the effective sacrifice of the Son/high priest. There is, however, no consensus about how this section should be subdivided into smaller sections. In this study I argue that Heb 8:1–10:18 is best understood as a "symphony" in three movements (8:1–13; 9:1–22; 9:23–10:18) on the themes of "sanctuary" (8:1–2; 9:1–10; 9:23–24), "sacrifice" (8:3–6; 9:11–15; 9:25–10:14), and "covenant" (8:7–13; 9:16–22; 10:15–18). The themes of "sanctuary" and "covenant" support the central theme of "sacrifice." The first movement (8:1–13), by alluding to Ps 110:1 and citing Jer 31:31–34, establishes the bare fact that Christ's sacrifice must be different from human sacrifices because it pertains to the heavenly sanctuary and establishes the new covenant. The second movement (9:1–22) describes the sacrifices used in the Tabernacle ritual and in the establishing of the old covenant by allusion to the Pentateuch. The purpose of this description is to show that these sacrifices were inadequate but pointed toward the adequate self-sacrifice of Christ and the cleansing power of His blood. The third movement (9:23–10:18) focuses on the quality of Christ's sacrifice by expounding Ps 110:1; Ps 40:6–8; and Jer 31:31–34. The high point of this symphony is reached in Heb 10:5–10, the heart of this third movement. These verses affirm that Christ's effective sacrifice is the willing offering of himself unto death as an obedient human being.
Endogenous Lipid-GPR120 Signaling Modulates Pancreatic Islet Homeostasis to Different Extents
Authors: Du Ya-Qin , Sha Xue-Ying , Cheng Jie , Wang Jin , Lin Jing-Yu , An Wen-Tao , Pan Wei , Zhang Li-Jun , Tao Xiao-Na , Xu Yun-Fei , Jia Ying-Li , Yang Zhao , Xiao Peng , Liu Ming , Sun Jin-Peng , Yu Xiao
Published: April 2022

Long-chain fatty acids (LCFAs) are not only energy sources but also serve as signaling molecules. GPR120, an LCFA receptor, plays key roles in maintaining metabolic homeostasis. However, whether endogenous ligand-GPR120 circuits exist and how such circuits function in pancreatic islets are unclear. Here, we found that endogenous GPR120 activity in pancreatic δ-cells modulated islet functions. At least two unsaturated LCFAs, oleic acid (OA) and linoleic acid (LA), were identified as GPR120 agonists within pancreatic islets. These two LCFAs promoted insulin secretion by inhibiting somatostatin secretion and showed bias activation of GPR120 in a model system. Compared with OA, LA exerted higher potency in promoting insulin secretion, which is dependent on β-arrestin2 function. Moreover, GPR120 signaling was impaired in the diabetic db/db model, and replenishing OA and LA improved islet function in both the db/db and streptozotocin-treated diabetic models. Consistently, the administration of LA improved glucose metabolism in db/db mice. Collectively, our results reveal that endogenous LCFA-GPR120 circuits exist and modulate homeostasis in pancreatic islets. The contributions of phenotype differences caused by different LCFA-GPR120 circuits within islets highlight the roles of fine-tuned ligand–receptor signaling networks in maintaining islet homeostasis.
Nrf2 Regulates β-cell Mass by Suppressing β-Cell Death and Promoting β-Cell Proliferation
Authors: Baumel-Alterzon Sharon , Katz Liora S. , Brill Gabriel , Jean-Pierre Clairete , Li Yansui , Tse Isabelle , Biswal Shyam , Garcia-Ocaña Adolfo , Scott Donald K.
Published: April 2022

Finding therapies that can protect and expand
functional b-cell mass is
a major goal of diabetes research. Here we generated b-cell-specific
conditional knockout and gain-of-function mouse models and used human islet
transplant experiments to examine how manipulating Nrf2 levels affects b-cell
survival, proliferation and mass. Depletion of Nrf2 in b-cells results in decreased
glucose-stimulated β-cell proliferation ex vivo and decreased adaptive
β-cell proliferation and β-cell mass expansion after a high fat diet in vivo. Nrf2 protects b-cells from apoptosis after a high fat diet. Nrf2 loss-of-function decreases Pdx1 abundance and
insulin content. Activating Nrf2 in a β-cell-specific manner increases β-cell
proliferation and mass and improves glucose tolerance. Human islets
transplanted under the kidney capsule of immunocompromised mice and treated
systemically with CDDO-Me, an Nrf2 activator, display increased β-cell proliferation. Thus, by managing ROS levels, Nrf2 regulates β-cell mass and is an exciting
therapeutic target for expanding and protecting b-cell mass in diabetes.
Type D Personality Is Associated with Poorer Quality of Life in Patients with Chronic Spontaneous Urticaria: A Cross-sectional Study
Authors: Sánchez-Díaz Manuel , Salazar-Nievas Maria-Carmen , Molina-Leyva Alejandro , Arias-Santiago Salvador
Published: April 2022

Type D personality (TDp) is a stable personality type that has been associated with poor quality of life in the general population and in patients with a variety of diseases, such as cancer, cardiac diseases, and dermatological diseases (e.g. psoriasis). To date, the potential association between chronic spontaneous urticaria and TDp has not been studied. The aim of this study is to analyse the impact of TDp on patients with chronic spontaneous urticaria, regarding mood disturbances, quality of life, sexuality, and sleep disturbances. A cross-sectional study including 75 patients with chronic spontaneous urticaria was performed. Data on socio- demographic variables and disease activity, quality of life, sleep, sexual dysfunction, anxiety, depression and TDp were collected using validated questionnaires. TDp was present in 28% (21/75) of the patients. Although TDp was not related to worse disease control, the presence of anxiety and depression was higher in patients with TDp. Regarding quality of life, TDp was associated with poorer quality of life and higher frequency of sleep disturbances. Prevalence of TDp in patients with chronic spontaneous urticaria is similar to that in the general population. It is associated with mood status disturbances and worse quality of life regardless of disease severity, especially in the emotional and psychological domains. This group of patients could benefit from additional psychological support as a complement to their medical treatment.
MODERN METHODS OF SUBMITTING INFORMATION IN THE CONTENT OF ALL-UKRAINIAN TV CHANNELS: FROM LONGRIDE TO FINISHING
Authors:   Lviv Polytechnic National University, Iryna Putsіata
Published: April 2022

In the article, the author examines the problems associated with increasing the relevance of television news programs in the context of intense competition between television and such modern media as news feeds, blogs, social networks, YouTube channels, which, due to their technical capabilities, can provide higher operational efficiency. presentation of news content compared to traditional televison news releases. In these conditions, television channels, as well as authors of television programs specializing in the genre of news television, have to look for fundamentally new approaches to broadcasting news, especially taking into account the capabilities of a modern person through various gadgets, they are constantly in the information news space. The article points out that attempts to "beat" the Internet as a source of information are futile for modern television; response. It is such formats that can contribute to solving the problems of news television are longread and financing, which are focused on broadcasting news through an appeal to the personality of the Hero of a television program, which is not only a form of increasing the competitiveness of the television news genre, but also carries a significant social potential. because in the center of the news is a person, as the main creator of events and its participant. The article points out that these formats on Ukrainian television are based on a human story that lasts in time, characterizes a fairly long cycle of events in which the hero takes part. Currently, this format is actively used by various television projects, among which the most successful are “Visiting Dmitry Gordon”, “Life of Vidomeh People”, “Secular News”. In the article, using the example of these projects, the features of longread and financial formats are described, their characteristic features are determined, as well as their prospects in the context of solving the problems of the domestic news genre on television.
Multi-scale structural inheritance of fracture systems pattern in coal-bearing measures of the Lorraine-Saar coal Basin
Authors: Pryvalov V. , Pironon J. , Donato P. de , Michels R. , Izart A. , Morlot C. , Panova O.
Published: April 2022

The Lorraine-Saar Basin (LSB) is one of the major Paleozoic coalfields of Western Europe that has been shapedover two centuries as a heartland of underground coal mining and associated industrial activities in the transborderarea of France and Germany. The Basin still has considerable coal reserves accumulated in numerous laterally continuous coal seams that were affected by processes of thermogenic production of gaseous hydrocarbons during post-Carboniferous burial and related coalification. The LSB stands out by its up to 6 km sedimentary column and its inversion resulting in Paleozoic erosion in the range of 750 m (French part of the Basin) and pre-Mesozoic (Permian) erosion between 1800 and 3000 m (German part of the Basin). Historically, coal production in the Lorraine and the Saar portions of the entire Basin was associated with numerous mining hazards because of the high methane content in coal seams. The LSB has the potential to host an enormous unconventional resource base including coalbed methane (CBM). Coal mines here are no longer operated to produce coal; however, methane generated in deep compartments is venting here via fracture swarms to the Earth’s surface. Cutting natural methane emissions throughout CBM production within coal-bearing terrains is a crucial opportunity for slowing global warming rates. Nearly all CBM plays worldwide are affected in some way by natural multiscale fracture sets ranging from large fault zones to closely spaced joints, micro-shears, or cleat sets in coal seams. The LSB is not excluded indeed from this trend because of the long-term experience of geological exploration during extensive coal mining in the past. Characterization of structural patterns of fracture networks at different scales is a pragmatic process boosting the reliable perception of the performance of coalbed methane gas reservoirs. The focus of this contribution is to get an insight into the style and kinematic description of the multi-scale fault and cleat patterns in the LSB based on results of subsurface and underground geological mapping, and X-ray computer tomography. It will benefit the right mindset to ensure proper technical decisions for efficient exploration and exploitation of CBM reservoirs in the Basin.
Introducción a la revitalización urbana y operadores urbanos en la ciudad de Medellín
Authors: Calvache Sepúlveda Juan Pablo
Published: April 2022

El artículo a continuación es un proemio del urbanismo en la ciudad de Medellín desde la figura jurídica de los operadores urbanos y la realidad socio-espacial que impone una expresión particular del capital. Es un escrito que pretende incoar las discusiones y problemas que atrae la planeación de la ciudad de Medellín desde la realidad neoliberal. Para esto aludiré al entorno teórico de la renovación urbana, seguiré con la estructura conceptual de los operadores urbanos, proseguiré con el contexto político institucional neoliberal y un fugaz compendio histórico del desarrollo urbano del Municipio de Medellín, para finiquitar con las normas específicas que atañen a la renovación urbana y el operador urbano en Colombia.
proceso de rebelión política de Yolanda Casas Quiroz del grupo guerrillero “Lacandones” (México, 1962-1969): subjetividades sociales, empoderamiento y género
Authors: Ávila Coronel Francisco
Published: April 2022

En el presente artículo se estudia la historia de vida de una mujer que perteneció a la llamada guerrilla urbana de los “Lacandones” que operó principalmente en la Ciudad de México. Como problema-eje propongo la pregunta ¿cuáles fueron las subjetividades sociales y mandatos de género implicados en la decisión de revelarse y levantarse en armas? Se explorará el proceso de empoderamiento y el significado que para ella tuvo su participación política en la Liga Comunista Espartaco (LCE) y su paso por el movimiento estudiantil de 1968, situando como eje de mi problematización las dificultades que enfrentó como hija, hermana, madre-esposa y cómo las relaciones de parentesco pesaron en su práctica política como militante revolucionaria. Se hará un análisis de la masacre ocurrida el 2 de octubre de 1968 en la plaza de las Tres Culturas de Tlatelolco articulando la violencia política con la masculinidad hegemónica.
Regulación de la producción de peces ornamentales y sus efectos excluyente en la agricultura familiar en Minas Gerais, Brasil
Authors: Chiaraba Gouveia Homero , Anchieta Ramirez Matheus , Figueiredo de Oliveira Alan , Teixeira Lopes Luana , Silva Camargo Gustavo Henrique , De Melo Hoyos Daniela Chemim
Published: April 2022

Este trabajo investiga las interrelaciones entre la regulación y los as-pectos económicos y ambientales en una comunidad de agricultores familiares en la región conocida como Zona da Mata Mineira, en el estado brasileño de Minas Gerais. El estudio es producto de una acti-vidad de extensión realizada entre 2016 y 2018, y tuvo como objetivo asesorar a los pequeños productores en el proceso de adecuación legal de la producción. Durante este período se realizaron cerca de cinco reuniones entre investigadores y comuneros, en las que se analizaron las dificultades encontradas por los pequeños productores en relación con el referido proceso. Las experiencias reportadas fueron confron-tadas con el régimen legal regulatorio para la actividad acuícola en Brasil, tomando como categorías de análisis los atributos de norma-tividad y facticidad del sistema legal. Se concluyó que la regulación ambiental en el área de la acuicultura en Brasil, diseñada para grandes productores, carga de manera desproporcionada a los pequeños pro-ductores, generando un desequilibrio económico injustificado. Como aporte a la teoría, se propone, en definitiva, la formulación de un con-cepto de regulación jurídica inclusiva, cuyos rasgos distintivos inclu-yen la participación social y la promoción de la alfabetización jurídica como derecho fundamental.
COVID-19 outbreak response at a nursing hospital in South Korea in the post-vaccination era, including an estimation of the effectiveness of the first shot of the Oxford-AstraZeneca COVID-19 vaccine (ChAdOx1-S)
Authors: Kim Chanhee , Kang Geon , Kang Sun Gu , Lee Heeyoung
Published: April 2022

Objectives: We descriptively reviewed a coronavirus disease 2019 (COVID-19) outbreak at a nursing hospital in Gyeonggi Province (South Korea) and assessed the effectiveness of the first dose of the Oxford-AstraZeneca vaccine in a real-world population.Methods: The general process of the epidemiological investigation included a public health intervention. The relative risk (RR) of vaccinated and unvaccinated groups was calculated and compared to confirm the risk of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, and vaccine effectiveness was evaluated based on the calculated RR.Results: The population at risk was confined to ward E among 8 wards of Hospital X, where the outbreak occurred. This population comprised 55 people, including 39 patients, 12 nurses, and 4 caregivers, and 19 cases were identified. The RR between the vaccinated and unvaccinated groups was 0.04, resulting in a vaccine effectiveness of 95.3%. The vaccination rate of the non-patients in ward E was the lowest in the entire hospital, whereas the overall vaccination rate of the combined patient and non-patient groups in ward E was the third lowest.Conclusion: The first dose of the Oxford-AstraZeneca vaccine (ChAdOx1-S) was effective in preventing SARS-CoV-2 infection. To prevent COVID-19 outbreaks in medical facilities, it is important to prioritize the vaccination of healthcare providers.
México frente a la Guerra de las Malvinas
Authors: Zeraoui Zidane , González Uresti Luz Araceli
Published: April 2022

A casi 40 años del llamado conflicto armado del Atlántico Sur, más conocido como la guerra de las Malvinas en la que se enfrentaron Argentina y el Reino Unido debido a que ambos Estados se disputaban la soberanía de dichas islas, analizar la posición de México ante esta confrontación resulta un ejercicio intelectual de amplias proporciones.
Zmiany zawartości cukrów w bulwach ziemniaka pod wpływem herbicydu i biostymulatorów
Authors: Zarzecka Krystyna , Gugała Marek , Domański Łukasz
Published: April 2022

Materiał badawczy stanowiły bulwy ziemniaka zebrane z trzyletniego doświadczenia polowego założonego w trzech powtórzeniach metodą split-plot. Pierwszy czynnik stanowiły dwie odmiany jadalne ‘Malaga’ i ‘Oberon’. Drugim czynnikiem było pięć sposobów aplikacji herbicydu i biostymulatorów: 1. obiekt kontrolny – bez herbicydu i biostymulatorów; 2. herbicyd Avatar 293 ZC; 3. herbicyd Avatar 293 ZC i biostymulator PlonoStart; 4. herbicyd Avatar 293 ZC i biostymulator Aminoplant; 5. herbicyd Avatar 293 ZC i biostymulator Agro-Sorb Folium. W świeżej masie bulw oznaczono zawartość cukrów ogółem, cukrów redukujących i sacharozy metodą Schoorla-Luffa. Odmiana ‘Oberon’ zawierała istotnie mniej cukrów ogółem, cukrów redukujących i sacharozy niż ‘Malaga’. Chemiczna regulacja zachwaszczenia nie miała wpływu na zawartość cukrów ogółem, miała tylko aplikacja wymienionych biopreparatów.
QHY-174M-GPS Camera as the Device for Photometry of Artificial Satellites
Authors: Kudak Viktor , Perig Vasyl
Published: April 2022

In this paper, we make an attempt to use the QHY174M-GPS camera for the photometry research of fast-rotating artificial objects including debris, satellites and rocket bodies. This device is useful for imaging occultations, eclipses, meteors, and so on due to a highly precise recording of the time (GPS-based) and location of the observation on every frame and fast readout of the CMOS detector. The precision of time registration by the QHY174M-GPS camera is at the level of microseconds. All light curves obtained by studied camera during observations of artificial satellites in this work were carried out at Derenivka Observatory of Uzhhorod National University, Ukraine. The created photometric system with QHY174M-GPS camera as the detector and reflector telescope with parameters D=120mm, F=114mm, FOV=2.82° × 1.76° was calibrated. For target observations, SharpCap software was used. For the purposes of photometry processing, ccd_phot software was developed using Python 3.8 programming language with astropy and photutils packages. Photometry observations of artificial satellites of the Earth and standard stars were carried out. Over 80 lightcurves of artificial satellites were obtained. Comparing synchronous observations from two sites, separated 15 km from each other, we can conclude that photometry on the QHY174M-GPS camera gave us the same shape of lightcurve and additional advantages, such as time of exposure or simplicity of usage.
Bayesian Inference for SIR Epidemic Model with dependent parameters
Authors: Qaffou Abdelaziz , Maroufy Hamid El , Zbair Mokhtar
Published: April 2022

This paper is concerned with the Bayesian inference for the dependent parameters of stochastic SIR epidemic model in a closed population. The estimation framework involves the introduction of m − 1 latent data between every pair of observations. Kibble’s bivariate gamma distribution is considered as a good candidate prior density of parameters, they give an appropriate frame to model the dependence between the parameters. A Markov chain Monte Carlo methods are then used to sample the posterior distribution of the model parameters. Simulated datasets are used to illustrate the proposed methodology.
Dynamic Motions of the Cabin Mounted on the Mono-Hull Planing Boat Using Suspension System in Waves
Authors: Bahrami Hassan , Ghassemi Hassan
Published: April 2022

The necessity for higher speed and appropriate seakeeping performance of boats has led to extensive research. Hence, this research mainly discusses the optimal behavior of the boat against motions. From an economic point of view, reducing motions of the boat minimizes the damage caused by shock and vibration to the boat and equipment. Other benefits include comfort and safety and, as a result, improved human operating ability. Suspension systems are rarely used as motion controller in a boat. In multi-hull boats, the hull is an inseparable part of the vessels, so the wave will affect crew and equipment. This paper proposes and evaluates a novel concept boat equipped with a suspended cabin. The hull and superstructure (cabin) are separated in this new form by a simple passive suspension system. This study used numerical analysis to examine the seakeeping performance of the planing boat Fridsma model equipped with a passive suspension system under regular wave conditions. The hydrodynamics of the planing hull were modeled using commercial software, STAR-CCM+. For simulation of the passive suspension system between boat and cabin, MATLAB software was used. Results showed that the motion of the cabin, which is where the crew and equipment are located, decreased in regular waves.