bluuebunny/crossref_metadata_2025 huggingface dataset:
Miejsca wspólne w prozie Doroty Terakowskiej i Marty Tomaszewskiej – rekonesans badawczy
Authors:   Uniwersytet Jana Kochanowskiego w Kielcach, Miernik Agnieszka
Published: April 2022

Common places in prose of Dorota Terakowska and Marta Tomaszewska – research reconnaissance The article presents the issue of themes common in the prose of Dorota Terakowska and Marta Tomaszewska. The fundamental problematic aspect in the work of Cracow and Warsaw writers focuses on literary topoi of power, a stone (holy mineral), parallel worlds (imaginary places), and the issue of imagination. Attention was paid to the issue of peregrination to the alternative land, and the examples are associated with the issue of crossing the border. During the translocation, the characters’ existence is affected by difficulties, suffering, dilemmas, and dualism; they become mature and enter adult life. The archetypical conception of a stone as a mineral refers to the sacrum, the center being the introduction to the superior order, is common for both writers. Presentation of the image of power has been recognized in various configurations, which allows an interpretation of the discussed topoi in the form of a symbol representing the aspect of difficult human experience. The power presented in a figurative way proves the necessity of humanizing existence.
Oko i lęk – notatki z autoodczuwania na podstawie powieści Tam, gdzie spadają anioły Doroty Terakowskiej
Authors:   Uniwersytet Rzeszowski, Ungeheuer-Gołąb Alicja
Published: April 2022

Image and fear. Notes from auto-feeling on the basis of the novel Where the angels fall down [Tam, gdzie spadają anioły] by Dorota Terakowska In this analysis, the authoress refers to the feelings of a recipient-researcher and, at the same time, a reader of a text employing a method of interpretation rooted in a phenomenological approach. She examines two aspects of reception: image –in the sphere of presentation, and fear – in the sphere of literary emotions. On that basis, employing a category of auto-feeling, the authoress interprets the content and form of prose by Dorota Terakowska in the piece
Samotność, cierpienie i ofiara – literacki obraz młodości w prozie Doroty Terakowskiej
Authors:   Uniwersytet Mikołaja Kopernika w Toruniu, Kruszyńska Elżbieta
Published: April 2022

Loneliness, suffering, and sacrifice – A literary picture of youth in Dorota Terakowska’s prose Adolescence is a very special period in everybody’s life, and a very interesting one for scientific research and for artists, especially for writers. This article describes methods of presenting adolescence in chosen books of Dorota Terakowska for young readers. The world in her books is characterized, on the one hand, by universal values and, on the other hand, by symbols. Young protagonists of her books are involved in difficult and complicated situations. There is loneliness, suffering, and sacrifice written into the young people’s lives. The protagonists’ demeanor and the way they cope with adversities make young readers more empathic and help them to see other people’s problems more clearly. In Dorota Terakowska’s books, young readers can find the answers to many pressing questions.
El difícil encaje de las diputaciones provinciales en el modelo de organización territorial del Estado: Una aproximación histórica (1812-1925)
Authors: Vera Torrecillas Rafael Jesús
Published: April 2022

El presente artículo pretende ofrecer un estudio sobre el proceso de evolución de las Diputaciones provinciales desde su creación en 1812 hasta su consolidación definitiva en el Estatuto Provincial de 1925, planteando las dificultades derivadas de su integración en el modelo de organización territorial implantado por el liberalismo. Desde su creación, la provincia y su organización a través de la diputación provincial ha sido objeto de continuos cuestionamientos tanto desde un punto de vista político como jurídico que deben llevarnos a reflexionar sobre su posición institucional desde el prisma de un modelo organizativo y competencial basado en la diversidad territorial.
COVID-19, policía administrativa y la modulación del principio de legalidad
Authors: Izquierdo Carrasco Manuel
Published: April 2022

Este estudio muestra que la clásica teoría de la policía administrativa, convenientemente acotada y constitucionalizada, ofrece una explicación satisfactoria de ciertas modulaciones en el sometimiento de la Administración al principio de legalidad que se han puesto de manifiesto en la actividad administrativa desarrollada frente al COVID-19. En particular, la validez de las cláusulas generales de apoderamiento contenidas en determinadas leyes sanitarias –que serían inadmisibles en otros sectores– y de las actuaciones praeter legem. Además, esta teoría aporta valiosos elementos que delimitan el alcance de estas modulaciones, tanto en su contenido como en sus destinatarios, y que parten de su fundamento: el deber jurídico de no perturbar el orden público. Por otro lado, el trabajo también explicita que la institución de la policía administrativa, complementada con la teoría del estado de necesidad, puede deslindar el espacio de legitimidad de las actuaciones administrativas contra legem, donde el jurista se ve en la necesidad de navegar entre el realismo jurídico y la posición radicalmente formalista del Tribunal Constitucional español, sin olvidar los graves riesgos que estas actuaciones pueden suponer para las libertades y derechos de los ciudadanos.
ANALISIS SPASIAL MODEL INVERSE DISTANCE WEIGHTING PADA PENYEBARAN KASUS POSITIF COVID-19 PER KABUPATEN DI PULAU JAWA
Authors: Huda Nur'ainul Miftahul , Imro'ah Nurfitri
Published: April 2022

Suatu lokasi saling berhubungan satu dengan yang lainnya dan sesuatu yang berjarak dekat memiliki pengaruh yang lebih dibandingkan dengan lokasi yang jauh. Hal ini yang mendasari adanya keterkaitan suatu kejadian antar lokasi atau disebut autokorelasi spasial. Salah satu metode yang dapat digunakan untuk melihat pola keterkaitan tersebut adalah metode Inverse Distance Weighting (IDW). Metode ini menggunakan faktor parameter pengaruh yaitu power (p) dalam melihat pengaruh lokal antar titik lokasi. Semakin besar niai p berarti nilai titik tak tersampel menjadi lebih terlokalisasi dan sebaliknya. InputÂ yang digunakan pada model ini adalah koordinat titik untuk titik tersampel beserta nilai dari setiap titik yang akan diestimasi. Pada penelitian ini kasus yang digunakan adalah kasus terkonfirmasi positif virus Covid-19 per 76 kabupaten/kota di Pulau Jawa hingga tanggal 26 Februari 2022. Penelitian ini bertujuan untuk melihat pemetaan kasus terkonfirmasi positif di Pulau Jawa per kabupaten melalui peta kontur menggunakan model IDW. Kabupaten/kota yang tidak dijadikan lokasi tersampel dapat diestimasi melalui model ini. Langkah pertama adalah membuat peta grid, kemudian menghitung jarak antar lokasi tersampel. Selanjutnya jarak tersebut digunakan untuk menghitung bobot setiap lokasi tersampel. Langkah berikutnya adalah estimasi nilai di lokasi tak tersampel menggunakan nilai power. NilaiÂ power yang digunakan pada penelitian ini adalah 0,5;1;2;3;4;5. Pemilihan nilaiÂ power yang tepat didasarkan pada nilai RMSE terkecil. Hasilnya diperoleh nilaiÂ power yang optimal adalah saat p=2 dan diperoleh estimasi kasus positif Covid-19 di lokasi tak tersampel sehingga diperoleh peta kontur.
The The social resistance to homosexuality in McCafe Taipei's advertising
Authors: Lobodally Altobeli
Published: April 2022

Advertising is not a tool to sell a product. The ideology that has been carried by the advertising creator is used to resist the common ideology. Homosexuality is still thought of as a sexual deviation and a crime. This research’s purpose is to disassemble the homosexuality in the Taipei McCafe’s advertising. This research is using popular culture, and Barthes’s analysis. From the second order of signification (denotation, connotation and myth) it is shown that having a gay son is a shame condition for a parent commonly. It is a hard situation for each parent to find out that his son loves a guy too. In the beginning, advertising is only a tool to sell the product, but this situation shows that becoming gay is a common thing. Homosexuality is just the sexual preference. Homosexuality it is not a sexual deviation. So parent nowadays, has to accept their son’s sexual preference. From this advertising, the advertisers are trying to resist the ideology about refusing the homosexuality.
Online reputation management with an Electronic word of mouth approach
Authors: Elmada Maria Advenita Gita , Elmaresa Maria Vina , Wardhani Shabriena , Putri Wita Adelina Noer
Published: April 2022

Opportunities for managing e-reputation for organizations have now begun to be captured by business activists in the communication technology industry in Indonesia. Several corporations from various industries have tried this service to increase their reputation in the digital world, especially on social media. One of the service companies that started to run an e-reputation management business and became the subject of this research is PT S. PT S's managing e-reputation will be analyzed using six elements included in the Online Public Relations tactical thinking developed by Phillips & Young. This study uses a qualitative approach and the nature of descriptive research, using case study methods, and collecting data using interviews and observations. As a result, PT S has implemented six elements of tactical thinking in its e-reputation management business, namely proactive and initiative actions, monitoring, publishing, raising awareness, stimulating engagement, and responding to events and actions. The use of e-WOM, the presence of influencers, the selection of suitable social media, and attractive content planning also affect the e-reputation of the clients' organizations.
Designing profile products as promotional media for brin publishers
Authors: Natalita Cempaka Destcarolina , Susilo Daniel
Published: April 2022

The development of BRIN publishers today is inseparable from the important role of the development of Information and Communication Technology. In its utilization brings the community into the era of 4.0 whose use is through digital systems. Through these developments, BRIN Publishers are required to transform, the transformation carried out is a change in the offering that used to be physical products now into digital products and publishing services in the form of open access and utilizing social media as a tool in promotional media. Based on this, it encourages BRIN publishers to form promotional strategies using new media. Profile products are used as a promotional medium for BRIN publishers who are expected to create good perception in building brand awareness and impact BRIN publisher engagement. The results of the profile product are expected to be an asset that can be officially uploaded into one of BRIN's social media platforms.
La dimensión trágica y simbólica en la obra dramática de Paloma Pedrero
Authors:   IES Marcos Zaragoza ,Alicante (España), Bas Albertos María José
Published: April 2022

Paloma Pedrero’s dramaturgy has received recognition from the public and critics. However, it has not been studied from the point of view of its tragic and symbolic dimension, although its theater is characterized by the emotional intensity of its characters. For this reason, starting from this vision of Paloma Pedrero’s brief theater as a creation that places the individual at the center, we propose to study some of these characters around whom dramatic tension is created. To do this, we will analyze its tragic character as opposed to the sainetesco or the manners; and its symbolism in relation to the archetypes and myths of the classical and modern tradition. Thus, the configuration of these characters will be compared with that of some classic theater heroes and with that of the protagonists of current cinematographic mythologies.
Identidades transicionales: pasado y presente en Éramos tan jóvenes (Antonia Bueno Mingallón)
Authors:   Universidad de Salamanca (España), Sevilla-Vallejo Santiago , Guzmán Mora Jesús ,   Universidad de Castilla-La Mancha (España)
Published: April 2022

Éramos tan jóvenes is the third part of the trilogy about the Spanish Transition to democracy by Antonia Bueno. In this play, the author presents the characters of Felipe, Mila and Lola, who meet in the funeral of Eva, the daughter of these, in the year 2001. By the use of the flashback, the piece goes through some of the most important events in the Spanish Transition from before the death of Franco since the last years of the 20th Century. The aim of this essay is, first, to analyze how the historical events are related to the lives of the three characters. And, secondly, to study the way in which the disorientation caused by the changes experienced in the Transition leads the characters to a diffuse identity because historical illusions are joined to their personal illusions.
Selection of modes and pressure regulation when pumping oil and oil products to save energy
Authors:   Omsk State Technical University, Shalay V. V. , Myznikov M. O. ,   Omsk State Technical University, Gildebrandt M. I. ,   Omsk State Technical University, Grinevich V. A. ,   Omsk State Technical University
Published: April 2022

The article presents the results of a study related to the choice of modes and pressure regulation to save electricity. Calculations are carried out on the example of a technological section of a specific oil pipeline. The paper demonstrates an approach to assessing the economic efficiency of each of the flow control options to obtain the required performance. The above arguments and methods of selecting modes can be applied to any oil pipelines and product pipelines.
E-skin: the future of sustainable & recyclable wearable electronics
Authors: Zhang Wei , Xiao Jianliang
Published: April 2022

An electronic “skin” can find applications in health care, robotics, and prosthetics, and can benefit the well-being, economy, and sustainability of our society. A sustainable futuristic electronic skin with superior stretching, self-healing, recycling, and reconfiguration capabilities has been developed by combining scientific advances in materials, electronics, mechanics and chemistry.
Determinants of Utilization and Quality of Antenatal Care Services in Lubumbashi, in the Democratic Republic of the Congo
Authors: Mpoy Charles Wembonyama , Katembo Barry Mukwarari , Ndomba Mathieu Mavu , Mishika Patricia Lukusa , Missumba Willy Kakozi , Mukuku Olivier , Wembonyama Stanislas Okitotsho
Published: April 2022

Objectives:

Maternal and perinatal mortality is one of the best indicators of a society’s health status and development level. In the Democratic Republic of the Congo, antenatal care (ANC) utilization is generally low, and delayed initiation of care is very common. It is in this context that the present study on the utilization and quality of ANC carried out among women in Lubumbashi city aimed to identify determinants of the utilization and quality of ANC services.

Material and Methods:

This was a cross-sectional study conducted in Lubumbashi, relating to 1472 women who had given birth during the 12 months preceding the survey, selected by cluster sampling. Logistic regression was used to identify the relative effects of socio-demographic risk factors and all statistical tests were declared significant at a P < 0.05.

Results:

One tenth (10.5%) of the women in the sample did not attend ANC during their most recent pregnancy and 89.5% had attended ANC at least once. Of the 1318 women with at least one ANC visit, 55.9% had an early initiation of ANC and 53.2% received high quality ANC. Women aged 20–29 years (adjusted odds ratios [aOR] = 2.8 [1.6–5.1]), 30–39 years (aOR = 4.3 [2.1–8.9]) and ≥40 years (aOR = 6.5 [2.6–16.2]), married women (aOR = 1.9 [1.1–3.2]), women with secondary educational level (aOR = 4.9 [3.4–7.2]), and women with higher educational level (aOR = 15.3 [5.3–43.8]) were more likely to have at least one ANC during their pregnancy. Factors contributing to attend four or more ANC visits were secondary educational level (aOR = 1.4 [1.0–2.0]) and higher educational level (aOR = 1.9 [1.2–2.9]), primiparity (aOR = 1.5 [1.1–2.1]), and doing business activities (aOR = 1.4 [1.0–1.8]). Determinant of early initiation ANC was only the higher educational level (aOR = 2.2 [1.4–3.4]). Factors associated with high quality ANC were secondary educational level (aOR = 3.0 [2.1–4.3]) and higher educational level (aOR = 6.2 [3.8–9.9]), and receiving ANCs in a general referral hospital (aOR = 1.5 [1.2–2.0]).

Conclusion:

The use and quality of ANC services remain a serious problem in Lubumbashi city. This situation hampers the achievement of maternal and child health goals. Health education can help reduce this in our context.
Pancreatic Solitary Fibrous Tumor as Result of Extracranial Metastatic Disease
Authors:   University of Puerto Rico-School of Medicine, Division of Gastroenterology Research, San Juan, Puerto Rico, P López-Marte , V Torres-Ortíz ,   Ponce Health Sciences University-School of Medicine, Division of Gastroenterology, Ponce, Puerto Rico
Published: April 2022

Solitary fibrous tumors and hemangiopericytomas (SFT/HPC) are an uncommon cause of pancreatic mass, and given its rarity data is limited. In this report, we present the case of a 61-year-old Female with history of SFT/HPC brain tumor, which was evaluated with abdominal imaging after presenting with an epigastric abdominal pain. A pancreatic mass was found and after endoscopic ultrasound- fine needle aspiration biopsy, she was found with extracranial metastatic disease. Our case adds clinical awareness and knowledge to this rare entity that needs to be considered when a pancreatic mass is found.
Circular RNA Circrna_0072387 Promotes Hepatoblastoma Progression by Regulating Hsa-Mir-490/Histone Deacetylase 2 Axis
Authors:   Department of Clinical Laboratory Medicine, Shanghai Tenth People’s Hospital of Tongji University, Shanghai, China, H Gou , R Yu ,   The Second School Affiliated to Fudan University, Shanghai, China, J Luo ,   Department of Clinical Laboratory Medicine, Shanghai Tenth People’s Hospital of Tongji University, Shanghai, China, L Liu ,   Department of Laboratory Medicine, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China, X Sun ,   Shanghai World Foreign Language Middle School, Shanghai, China, C Xu ,   Department of Clinical Laboratory Medicine, Shanghai Tenth People’s Hospital of Tongji University, Shanghai, China
Published: April 2022

Circular RNAs have been reported to be associated with the occurrence and progress of various cancers. However, its biological roles in hepatoblastoma (HB) remain undefined. This study intended to explain a possible mechanism of hsa_circ_0072387 (circ72387) in hepatoblastoma progression. The expression of circ72387, hsa-miR-490 (miR490) and histone deacetylase 2 (HDAC2) in HB tissues and cell lines (HepG2/Huh6) were determined by quantitative realtime polymerase chain reaction (qPCR) or Western blot. Cell Counting Kit-8 (CCK-8) and colony formation assay were used to detect the proliferation of HB cell lines. The interaction between miR490 with circ72387 was predicted by CircInteractome and was verified by Dual-Luciferase reporter assay while the interaction between miR490 with HDAC2 was predicted by Targetscan and was verified by western blotting assay. Results showed that circ72387 was upregulated in both HB tissues and cells, and miR490 was downregulated in HB cells. Furthermore, the silence of circ72387 suppressed the proliferation of hepatoblastoma cells. Circ72387 promoted the proliferation of HB cells through competitively binding to HDAC2 against miR490 acting as a Sponge of miR490 in HB. Circ72387 played an essential role in HB development through the circ72387-miR490-HDAC2 regulatory axis, which may pave the way for potential diagnostic markers and therapeutic targets research in HB.
A Dynamic Helical Supramolecular Peptide Framework Displaying Enantioselective Guest Adsorption
Authors: Brightwell Dominc F. , Truccolo Giada , Samanta Kushal , Fenn Elliott J. , Holder Simon J. , Shepherd Helena J. , Hawes Chris S. , Palma Aniello
Published: April 2022

The ability to use bio-inspired building-blocks in the assembly of novel supramolecular frameworks is at the forefront of this exciting research field. Herein, we present the first helical polyproline peptide to self-assemble to form a reversibly porous, crystalline, supramolecular peptide framework (SPF). This framework is assembled from a short oligoproline, adopting the polyproline II conformation, driven by hydrogen-bonding and pi-interactions. Thermal activation, guest-induced dynamic porosity and enantioselective guest inclusion have been demonstrated for this novel system. The principles of the self-assembly associated with this SPF will be used as a blueprint allowing for the further development of helical, proline-based peptide linkers in the rational design of SPFs and metal-peptide frameworks.
On the possibility that bond strain is the mechanism of RING E3 activation in the E2-catalyzed ubiquitination reaction
Authors: Johnson Jay-Anne K. , Sumner Isaiah
Published: April 2022

Ubiquitination is a type of post translational modification wherein the small protein ubiquitin (Ub) is covalently bound to a lysine on a target protein. Ubiquitination can signal for several regulatory pathways including protein degradation. Ubiquitination occurs by a series of reactions catalyzed by three types of enzymes: ubiquitin activating enzymes, E1; ubiquitin conjugating enzymes, E2; and ubiquitin ligases, E3. E2 enzymes directly catalyze the transfer of Ub to the target protein – the RING E3 improves the efficiency. Prior to its transfer, Ub is covalently linked to the E2 via a thioester bond and the Ub~E2 conjugate forms a quaternary complex with the RING E3. It is hypothesized that the RING E3 improves the catalytic efficiency of ubiquitination by placing the E2~Ub conjugate in a “closed” position, which tensions and weakens the thioester bond. We interrogate this hypothesis by analyzing the strain on the thioester during molecular dynamics simulations of both open and closed E2~Ub/E3 complexes. Our data indicate that the thioester is strained when the E2~Ub conjugate is in the closed position. We also show that the amount of strain is consistent with the experimental rate enhancement caused by the RING E3. Finally, our simulations show that the closed configuration increases the populations of key hydrogen bonds in the E2~Ub active site. This is consistent with another hypothesis stating that the RING E3 enhances reaction rates by preorganizing the substrates.
On the surface-to-bulk partition of proteins in extracellular vesicles
Authors: Zendrini Andrea , Guerra Giorgia , Sagini Krizia , Vagner Tatyana , Di Vizio Dolores , Bergese Paolo
Published: April 2022

Nanomaterials are characterized by extremely large surface-to-volume ratio. Extracellular Vesicles (EVs) – which have been recently recognized as the universal agent of intercellular communication, being involved in many physiological and pathological processes and in interkingdom biochemical communication – are nanoparticles, but this key aspect has never been rationally addressed. Here we report the first attempt to quantify the membrane-to-lumen partition of proteins in EVs. A semi-quantitative model based on available well-established compositional and microstructural data is formulated. The model allows for estimation of the overall protein content of an EV as well as of the partition between membrane (surface) associated and lumen (bulk) contained proteins as a function of the EV size and shape. It further identifies 180 nm as a key diameter, below which EVs result composed by more membrane than luminal proteins. At larger diameters the partition is reversed, reaching predominance of luminal proteins (> 80 %) in large EVs (diameter > 800 nm). The model is successfully tested to analyze and describe a real preparation composed of subpopulations of small EVs (diameter < 200 nm), including exosomes and ectosomes, and large EVs including large oncosomes (diameter > 1000 nm) from human prostate cancer cells. These findings provide basis for better colloidal description of EV samples, might help to understand the stoichiometry of proteins in distinct EV sub-populations and will improve design and interpretation of experiments, including EV engineering and dosing in-vitro and in-vivo.
Explaining Regio-Divergent Vinylations with Vinylbenziodoxolones
Authors: Di Tommaso Ester , Norrby Per-Ola , Olofsson Berit
Published: April 2022

Vinylbenziodoxolones have recently been identified as efficient hypervalent iodine(III) reagents for electrophilic vinylations under transition metal-free conditions. The regiochemistry of the products have been found to vary with the nucleophile class, with thiols giving internal alkenes whereas phosphine oxides and similar P-nucleophiles give terminal alkenes. This paper constitutes the first mechanistic investigation of VBX vinylations, and makes use of NMR studies, deuterium label-ling and computations to rationalize the observed regio- and stereochemical outcome. While the S-vinylation was found to proceed through the ligand coupling mechanism typical of diaryliodonium salts, the P-vinylations took place via a phos-phinous acid-coordinated VBX complex, which underwent concerted deprotonation and Michael-type addition. Subsequent base-assisted protonation and E2 elimination delivered the terminal alkene. The findings can be used to predict the regiose-lectivity in vinylations of other nucleophile classes.
CONCEPTOS CLAVES DE LA GESTIÓN CULTURAL. ENFOQUES DESDE LATINOAMÉRICA. VOLÚMEN I
Authors: Chavarría Rafael
Published: April 2022

Esta obra tiene como primer objetivo brindar un primer acercamiento al lenguaje de la gestión cultural en Latinoamérica. Un intento de poner palabras, de realizar una reflexión de lo que se hace y se piensa desde diversos lugares de nuestras múltiples y extensas realidades que nos caracterizan.
Functional and structural deficiencies of Gemin5 variants associated with neurological disorders
Authors: Francisco-Velilla Rosario , Embarc-Buh Azman , del Caño-Ochoa Francisco , Abellan Salvador , Vilar Marçal , Alvarez Sara , Fernandez-Jaen Alberto , Kour Sukhleen , Rajan Deepa S , Pandey Udai Bhan , Ramón-Maiques Santiago , Martinez-Salas Encarnacion
Published: April 2022

Dysfunction of RNA-binding proteins is often linked to a wide range of human disease, particularly with neurological conditions. Gemin5 is a member of the survival of the motor neurons (SMN) complex, a ribosome-binding protein and a translation reprogramming factor. Recently, pathogenic mutations in Gemin5 have been reported, but the functional consequences of these variants remain elusive. Here, we report functional and structural deficiencies associated with compound heterozygosity variants within the Gemin5 gene found in patients with neurodevelopmental disorders. These clinical variants are located in key domains of Gemin5, the tetratricopeptide repeat (TPR)–like dimerization module and the noncanonical RNA-binding site 1 (RBS1). We show that the TPR-like variants disrupt protein dimerization, whereas the RBS1 variant confers protein instability. All mutants are defective in the interaction with protein networks involved in translation and RNA-driven pathways. Importantly, the TPR-like variants fail to associate with native ribosomes, hampering its involvement in translation control and establishing a functional difference with the wild-type protein. Our study provides insights into the molecular basis of disease associated with malfunction of the Gemin5 protein.
Prevalence and Determinants of Central Obesity at Urban Slum Dwellers in North Jakarta
Authors: Astiarani Yunisa , Kedang Maria G.A.I. , Fitriah Nur , Chandra Fani A.
Published: April 2022

Central obesity, widely known as a major cardiovascular disease risk factor, threatens the urban poor more than other socio-economic groups. The study intended to disclose the prevalence and determinants of central obesity in urban slum dwellers in North Jakarta. We conducted a survey study on residents aged 15 and above. The study randomly recruited two hundred forty-eight residents for direct interviews and body measurements according to the minimum sample requirement. Sociodemographic and Noncommunicable Diseases (NCDs) risk factors questionnaires were used and asked after weight, height, and waist circumference measurements. Descriptive and multivariate analyses were conducted to determine the central obesity prevalence and associated determinants. The central obesity prevalence in urban slum dwellers reaches 68.1%, presiding in women (69.4%) than men (65.3%). The multivariate binary logistic regression analysis indicates that central obesity was higher in the 30-59 y.o age group (Prevalence Ratio [PR]= 1.68; 95% Confidence Interval [CI]=1.19-2.37) and ≥ 60 y.o age group (PR = 1.76; 95%CI = 1.20-1.41). Besides, the residents who do not eat fruits and vegetables daily (PR=1.20; 95%CI=1.01-1.41) and practice less physical activity (PR=1.25; 95%CI=1.01-1.56) were more likely to have central obesity. The productive age group and elderly are at a higher risk for central obesity in an urban slum. Although notable as the main risk factors for central obesity, less consumption of fruits, vegetables and lack of physical activity highlight the urgent need to provide affordable, healthier options for urban slum dwellers.
Tetralogia de Fallot em um cão da raça Shih Tzu: relato de caso
Authors: Herrera Gustavo Cavinato , Pereira Clara Boaventura , Resende Henrique Caixeta , Mantovani Matheus Matioli , Milken Vanessa Martins Fayad
Published: April 2022

A tetralogia de Fallot é uma doença cardíaca congênita caracterizada por quatro alterações, sendo elas a dextroposição da aorta, defeito do septo interventricular, hipertrofia concêntrica do ventrículo direito e estenose da valva pulmonar. O objetivo deste trabalho foi relatar um caso de tetralogia de Fallot em um cão da raça Shih Tzu. Um canino, da raça Shih Tzu, de 1 ano e 6 meses de idade, foi atendido com queixa principal de episódios de desmaio e dificuldade de respirar que se iniciaram aos 6 meses de idade. Foi realizada oxigenoterapia para estabilizar a angústia respiratória do animal, e o paciente foi encaminhado para ecodopplercardiograma no qual foi constatada a presença das quatro alterações condizentes com a tetralogia de Fallot, o grau de estenose pulmonar foi classificado como moderado e no hemograma foi evidenciada a presença de policitemia absoluta. Como o animal apresentou hematócrito acima de 70% foi indicada a flebotomia e o uso do propanolol na dose de 0,5 mg/Kg, três vezes ao dia como indicado na literatura. Após o tratamento foi observada melhora do quadro clínico. Na impossibilidade de acompanhar o paciente aumentou-se a dose de propranolol para 1mg/Kg/ a cada 8 horas.  O caso relatado contribuiu para a literatura escassa sobre essa enfermidade em pequenos animais, especialmente na raça Shih Tzu.
Composição físico-química do colostro e do leite de porcas durante a lactação sob condições tropicais
Authors: Araújo Lina Raquel Santos , Vasconcelos Deborah Marrocos Sampaio , Maia Filho Gerardo Sousa , Silva Caio Vitor Oliveira , Andrade Tiago Silva , Evangelista Jose Nailton Bezerra
Published: April 2022

A ingestão de leite combinada com a sua concentração de proteína é responsável por mais de 80% da variação total no ganho de peso dos leitões durante a lactação. Neste sentido este estudo teve o propósito de determinar a variação da composição físico-química do colostro e do leite de porcas durante a lactação sob condições tropicais. O estudo foi conduzido em uma granja comercial, em que se utilizou 55 matrizes multíparas para coleta de colostro, nas primeiras 24 horas após o parto e leite aos 7, 14 e 21 dias pós-parto. As amostras foram avaliadas quanto ao pH, densidade e aos níveis de matéria seca, lactose, proteína e gordura. O colostro apresentou pH mais ácido, maior densidade e maiores níveis de matéria seca, proteína e lactose em relação ao leite (P<0,0001). Portanto, este estudo evidencia que a composição físico-química do leite é alterada conforme os dias de lactação, apresentando pH ácido e maiores concentrações de nutrientes, a exceção da gordura, no primeiro leite (colostro) e ao longo da lactação os níveis de matéria seca, lactose e proteína do leite decrescem apresentando-se mais baixos aos 21 dias de lactação com pH mais próximo da neutralidade.
Avaliação de formulações tópicas à base de alecrim (Rosmarinus officinalis L.) e trigo (Triticum aestivum) no tratamento da otite externa induzida em ratos Wistar
Authors: Negri Mueller Eduardo , Brito Risciela Salardi Alves de , Fontoura Eduardo Garcia , Santin Rosema , Nobre Anciuti Andreia , Gevehr Fernandes Cristina , Freitag Rogerio Antônio , Jorge Sérgio , Oliveira Nobre Marcia
Published: April 2022

A otite externa é uma doença inflamatória do canal auditivo externo e a terapia tópica é o principal tratamento. A identificação de novos produtos derivados de plantas pode ser usada como alternativa terapêutica viável com menos efeitos tóxicos. Neste trabalho, otite externa foi induzida experimentalmente em 48 ratos Wistar utilizando óleo de cróton em acetona e as alterações foram ranqueadas clinicamente de acordo com a severidade das lesões. Foram utilizados três tratamentos tópicos à base de extratos vegetais ou óleos essenciais de alecrim (Rosmarinus officinalis) e trigo (Triticum aestivum) por sete dias consecutivos. A extração do óleo essencial de alecrim foi através da técnica de hidrodestilação e submetido à cromatografia. Os extratos aquosos foram obtidos através de técnica de ultrassom por esgotamento e analisados empregando a técnica de cromatografia líquida de alta eficiência. O grupo I (GI) foi tratado com extrato aquoso de alecrim 25% em propilenoglicol, o GII foi tratado com óleo essencial de alecrim 25% em propilenoglicol, GIII com extrato aquoso de trigo 0,2% em propilenoglicol e o grupo controle (GIV) recebeu NaCl 0,9%. Nos dias zero, quatro, seis e dez houve reavaliações otológicas clínicas e histopatológicas. A evolução clínica da otite dos animais tratados com os extratos aquosos de ambas as plantas mostrou efeito terapêutico. Os grupos GI e GIII decresceram os escores clínicos aos quatro dias comparados ao grupo controle. Conclui-se que o extrato aquoso de trigo 0,2% e o extrato aquoso de alecrim 25% reduzem os escores clínicos em otite não infecciosa em modelo experimental.
Análise clínica e histológica de feridas cirúrgicas de cadelas tratadas com um composto fitoterápico de Calendula officinalis, Aloe vera, Symphytum officinale L., Vitis vinifera, D-Pantenol e Benzoato de Denatônio®
Authors: Ferreira Maria Sheila da Silva , Aleixo Grazielle Anahy de Sousa , Mendonça Fábio de Souza , Evêncio Neto Joaquim , Penaforte Junior Mauro Araujo , Trajano Sabrina Cândido , Melo Kleyton Domingos , Gonçalves Saulo Romero Felix , Camargo Karine Silva , Galeas Gabriela Ratis
Published: April 2022

Esse experimento teve como objetivo avaliar o potencial cicatricial de uma loção fitoterápica formulada com Calendula officinalis – 1,0%, Aloe vera – 1,0%, Symphytum officinale L. – 1,0%, Vitis vinifera – 1,0%, D-Pantenol – 3,0% e Benzoato de Denatônio – 0,02%, (PSK Repair System®) que foi aplicada topicamente sobre feridas cirúrgicas de cadelas. O grupo experimental foi composto por 30 cadelas que foram submetidas à ovariohisterectomia (OH), sendo realizada uma incisão de cinco centímetros na linha abdominal ventral para acesso cirúrgico, e a ferida foi dividida em duas partes iguais de 2,5 cm. No pós-operatório foi aplicada diariamente, durante sete dias, sobre a parte cranial a loção fitoterápica (Grupo Tratado - GT), enquanto que na parte caudal foi aplicada uma loção à base de vaselina (Grupo Controle - GC). Com sete (D7), 14 (D14) e 21 (D21) dias foram escolhidas aleatoriamente cinco pacientes de cada grupo para realização de análise macroscópica da ferida cirúrgica e exame histopatológico. Clinicamente se observou que no GT houve melhora no processo de reparação tecidual, fato esse que foi reforçado pelo exame histopatológico no qual foi possível observar que a presença de infiltrados mononucleares foi menor, enquanto que a presença de fibroblastos e neovascularização se apresentaram de forma mais efetiva que no GC. Diante dos achados, conclui-se que a loção fitoterápica agiu sobre a ferida cirúrgica ajudando no reparo tecidual, suscitando subsídios científicos que fundamentem seu uso como cicatrizante na rotina cirúrgica veterinária.
Challenges in preoperative diagnosis of glossopharyngeal nerve schwannoma: own findings analysis
Authors: Skobska O.E. , Sirko A.H. , Zemskova O.V. , Lisianyi O.M. , Popovych I.O. , Malyi R.R.
Published: April 2022

Medical history, disease onset, clinical symptoms, and results of neuroimaging of 14 glossopharyngeal schwannoma patients, who were exa­mined and treated in the Subtentorial Neurooncology Department of the State Institution, Romodanov Institute of Neurosurgery of the NAMS of Ukraine (8 patients) and the Neurosurgery Department No. 2 of the Municipal Enterprise, Mechnikov Dnipropetrovsk Regional Clinical Hospital of Dnipropetrovsk Regional Council (6 patients) in 2018 to 2021 have been analyzed in details. The study inclusion criteria were as follows: patient’s age over 18, pre­sence of unilateral primary glossopharyngeal nerve schwannoma. Our study showed that most of clinical signs and symptoms of the glossopharyngeal nerve schwannoma are associated with otolaryngological disorders (such as hearing loss, tinnitus, hoarseness, or dizziness) or cerebellar disorders (such as ataxia, nystagmus, or dizziness). Neuroimaging cerebellopontine angle tumors diagnosis must include brain computed tomography (with mandatory assessment of the state of jugular foramen and internal auditory canal) and IV contrast brain magnetic resonance tomography and inclusion of high-resolution sequences, gradient echo (3D CISS, DRIVE, TRUFFI, B-FFE) with the aim of better visualization and differentiation of various cerebellopontine angle cranial nerves. The study demonstrates the com­plexity of a reliable preoperative diagnosis when using standard diagnostic tools. Preoperative jugular foramen and cerebellopontine angle tumors diagnosis should be based on a systematic approach and include a comparison of results of comprehensive clinical and instrumental examination and neuroimaging studies.
Mesenteric thrombosis in patients with coronavirus disease: comprehensive assessment and treatment
Authors: Stasyshyn A.R. , Stadnyk I.S. , Doroshak A.I. , Polianytsia I.M. , Bokhonko R.L. , Demianovych T.M. , Matviychuk O.B.
Published: April 2022

Acute mesenteric circulatory disorder belongs to the most serious diseases of the abdominal cavity. Being an emer­gency condition, it is associated with high mortality. Coronavirus infection is an anthroponotic disease in the group of acute respiratory infections, is characterized by damage to the upper respiratory tract, severe intoxication, coagu­lopathy and in severe cases - multiple organ failure. The aim of the work was to analyze the results of the surgical treatment of mesenteric vascular thrombosis in patients with COVID-19. We have studied the results of diagnostics and treatment of 13 patients (9 males and 4 females) with acute mesenteric thrombosis and COVID-19. We have analyzed patients’ complaints and the clinical picture of the disease, as well as performed general medical examination (routine blood and urine tests, biochemical parameters, coagulogram), X-ray examination of abdominal and thoracic cavities, computed tomography / angiography of abdominal organs, diagnostic laparoscopy, diagnostic mini-laparotomy and laparotomy. The symptoms of the disease include nausea, vomiting, abdominal pain, diarrhea, fever, cough, shortness of breath and belching. The disease was diagnosed by contrast computed tomography. Four patients developed simultaneous thrombosis – stroke, thrombosis of the portal and mesenteric veins, splenic and renal infarction, thrombosis of the superior mesenteric and portal veins. Six patients have been suffering from underlying health conditions, 7 patients – had none. Ten patients underwent surgery (laparotomy with resection of the nonviable intestine), 3 – received conservative treatment (heparin therapy). Six patients died (4 out of 10 – during surgery and 2 out of 3 – during conservative treatment). Postoperative mortality was 40%.
Single nucleotide variants of filaggrin and glucocorticoid receptors genes in children suffering different phenotypes of atopic diseases
Authors: Dityatkovsky V.O. , Naumenko N.V. , Alifirenko О.O. , Pinaeva N.L. , Taran S.T. , Filatova I.A. , Abaturov O.Ye.
Published: April 2022

Currently, there is an apparent need for genotype-associated personalization of the diagnostic process for atopic diseases (AtD) in children: atopic dermatitis (AD), seasonal allergic rhinitis (conjunctivitis – (SAR(C)), perennial allergic rhinitis (conjunctivitis – (PAR(C)) and bronchial asthma (BA) in different phenotype combinations - monotopic and polytopic. The aim of the study was to identify associations of the genotype variants of SNV rs_7927894 of FLG gene, rs10052957 and rs41423247 of NR3C1 gene in children with AD, SAR(C), PAR(C) and/or BA in mono- and polytopic phenotypes. The study recruited 293 children with AD who were divided into 6 phenotypic clusters: monotopic phenotypes: No. 1 – AD (58 patients); No. 2 – SAR(C)/PAR(C) (71 patients); No. 3 – BA (23 patients); polytopic phenotypes: No. 4 – AD+ SAR(C)/PAR(C) (43 patients), No. 5 – BA+SAR(C)/PAR(C) (72 patients), No. 6-AD+BA+SAR(C)+PAR(C) (26 patients). In patients of all 6 clusters buccal swab of the oral mucosa was taken for genotyping the variants: C/C, C/T, T/T SNV rs7927894 of FLG gene; A/A, A/G, G/G SNV rs10052957 and C/C, C/G, G/G SNV rs41423247 of NR3C1 gene. Heterozygous variant C/T SNV rs_7927894 FLG is the most common, directly associated and significantly increases the risk of polytopic AtD phenotypes: AD+SAR(C)/PAR(C) by 2.47 (95% CI 1.14-5.38, p<0.05) times and AD+BA+SAR(C)+PAR(C) – by 3.13 times (95% CI 1.24-7.95, p<0.05) related to monotopic phenotype SAR(C)/PAR(C). The heterozygous variant A/G SNV rs10052957 of the NR3C1 gene is the most common in all AtD phenotypes, except for monotopic BA and polytopic AD+SAR(C)/PAR(C), and significantly, by 0.40 times (95% CI 0.18-0.93, p<0.05) reduces the risk of the polytopic phenotype related to AD. Homozygous variant G/G SNV rs10052957 of the NR3C1 gene is most common in the monotopic phenotype SAR(C)/PAR(C) and polytopic AD+SAR(C)/PAR(C) as well as in AD+BA+SAR(C)/PAR(C) and significantly increases by 2.97 times (95% CI 1.31-6.74, p<0.05) and decreases by 0.45 times (95% CI 0.21-0.97, p<0.05) the risk of developing AD+SAR(C)/PAR(C) related to AD. Heterozygous variant A/G rs10052957 of the NR3C1 gene significantly reduces by 0.40 times (95% CI 0.18-0.93, p<0.05) the risk of polytopic phenotype BA+SAR(C)+PAR(C) related to AD+SAR(C)/PAR(C). Heterozygous variant C/G SNV 41423247 of the NR3C1 gene was the most common and significantly increased by 2.03 times (95% CI 1.01-4.10, p<0.05) the risk of monotopic  AD phenotype related to SAR(C)/PAR(C).
Current state and strategic directions of development of state management of nursing education in Ukraine
Authors: Striukov V.V. , Grynko T.V. , Krupskyi O.P. , Vazov R.G.
Published: April 2022

The article presents the results of the study of the current state of public administration and strategic directions of development of nursing education in Ukraine by on the example of Dnipropetrovsk region. The region was chosen because it ranks second in Ukraine in terms of population (first place Donetsk region). The purpose of the study is to determine the strategic prospects for reform and effective development of the medical sector, in particular the education system of health workers on the basis of the study of the current state of public health management. The article has a conceptual nature, so the following research methods were chosen: systematization and generalization; analysis and specification; abstract-logical. An analysis of the scientific database of domestic and foreign researchers found that public administration of the secondary medical education system, including the health care system, is in crisis and is characterized by globality, longevity and complexity. According to the results of statistical processing of primary data, it was found that despite the high level of graduates in the specialty «223 Nursing» of degrees professional junior bachelor and bachelor for five years (from 2016 to 2020) the number of nurses decreased by 21.6004% and this negative trend continues. State management of nursing education was defined as a special type of professional activity, the purpose and result of which is to ensure, support life and dynamic development of the industry whose main mechanisms are: regulatory-legal, coordination, organizational-motivational, educational-pedagogical, economic. The article emphasizes the need to develop strategic directions for the development of public administration in the system of medical education, which would provide medical institutions with highly qualified specialists, taking into account the market of educational services and the needs of society, to create and implement an effective resource mobilization mechanism to meet the needs of medical education, taking into account continuous professional development to train highly qualified professionals.
Transformations of the dental industry during the period of independence of Ukraine and their impact on the availability of dental care
Authors: Mazur I.P. , Lekhan V.N. , Rybachuk A.V.
Published: April 2022

The article presents an analysis of the transformations of the dental industry in different periods of development of the health care system from 1991 to 2020 and their impact on the availability of dental care. The materials of the study were regulations, statistics on the infrastructure and human resources of the dental industry in Ukraine. Bibliosemantic, historical, analytical, medical-statistical and biostatistical research methods are used. The article presents an analysis of the number of dental institutions and dentists per capita at different stages of development of the health care system of Ukraine. The transformation of Ukraine’s health care system in 2015-2020 has led to a significant reduction in dental clinics and human resources in the Ministry of Health of Ukraine with a significant increase in the number of private clinics and dentists providing dental care. The share of working dentists in the public health relative to the private sector is declining: in 2017, 72% worked in public institutions and 28% – in private institutions; in 2020 – 59.7% and 40.3% respectively. Ukraine has a developed infrastructure and human resources for dental care. The transformation of the health care system leads to a reduction in the number of dental facilities and staff in the system of Ministry of Health, which is not offset by the intensive development of the private sector and reduces the availability of dental care. The introduction of innovative technologies increases the complexity of the work of dentists and, accordingly, requires an increase in the number of dentists. The policy in the field of dental education does not allow to prepare a sufficient number of dentists for the industry and to compensate for migration processes of labor dental potential to European countries.