bluuebunny/crossref_metadata_2025 huggingface dataset:
Image analysis using the Fluorescence Imaging of Nuclear Staining (FINS) algorithm
Authors: R Laura Bramwell , Spencer Jack , Frankum Ryan , Manni Emad , W Lorna Harries
Published: August 2023

Finding appropriate image analysis techniques for a particular purpose
can be difficult. In the context of the analysis of immunocytochemistry
images, where the key information lies in the number of nuclei
containing co-localised fluorescent signals from a marker of interest,
researchers often opt to use manual counting techniques because of the
paucity of available tools. Here, we present the development and
validation of the Fluorescence Imaging of Nuclear Staining (FINS)
algorithm for the quantification of fluorescent signals from
immunocytochemically-stained cells. The FINS algorithm is based on a
variational segmentation of the nuclear stain channel and an iterative
thresholding procedure to count co-localised fluorescent signal from
nuclear proteins in other channels. We present experimental results
comparing the FINS algorithm to the manual counts of seven researchers
across a dataset of three human primary cell types which are
immunocytochemically-stained for a nuclear marker (DAPI), a biomarker of
cellular proliferation (Ki67) and a biomarker of DNA damage (γH2AX). The
quantitative performance of the algorithm is analysed in terms of
consistency with the manual count data and acquisition time. The FINS
algorithm produces data consistent with that achieved by manual
counting, but improves the process by reducing subjectivity and time.
The algorithm is simple to use, based in software that is omnipresent in
academia, and allows data review with its simple, intuitive user
interface. We hope that, as the FINS tool is open source and is custom
built for this specific application, it will streamline analysis of
immunocytochemical images.
On-line chloride removal from ion chromatography for trace-level analyses of phosphite and other anions by coupled IC-ICPMS
Authors: Stueeken Eva , Baidya Abu S.
Published: August 2023

Rationale: Ion chromatography combined with inductively-coupled
plasma mass spectrometry is an ideal tool for measuring low
concentrations of anionic species such as phosphite; however, the high
concentration of chloride and other anions in natural solutions may
negatively impact chromatographic separation and data quality.
Method: We developed an on-line mechanism of removing chloride
from the sample within the ion chromatograph, using an additional valve
and a separation column that transfers chloride to waste while phosphite
and most other anions are retained. We installed this system in a
coupled IC-ICPMS system (ICS6000 and Element 2 in medium resolution
mode) and determined linearity and detection limits. In addition, we
measured phosphorous species by NMR for comparison as an alternative
method for phosphite determination. Results: Chloride was fully
removed from the samples while phosphite was retained and could be
analysed by IC-ICPMS. Concentrations could be measured down to 0.003
µmol/L and possibly less with good linearity over the explored range (up
to 1.615 µmol/L; r = 0.999). In contrast, the
detection limit by NMR was 6.46 µmol/L. Conclusions: The
on-line removal mechanism works well for simplifying sample matrices. It
removes the need for costly pre-analytical sample treatment with OnGuard
columns. We confirm that IC-ICPMS is the most powerful technique for
quantifying phosphite in natural solutions. The new Cl-removal method
may also be applicable to analyses of other anions.
The Effect of Group Dynamics on Individual Ethical Decision Making
Authors: Daniel Rachel , Douglass Ashley , Kluetz Abagail , Persellin Julie
Published: August 2023

Given that many significant decisions in accounting are made by groups of professionals, it is important to understand the impact of group interactions on ethical decision making. We examine how group dynamics can influence an individual’s ethical evaluations and intentions and whether the effect of these group interactions persists in the future. We also explore the ethical orientations used by participants to inform their ethical judgments. Our results indicate that individual initial assessments of ethical scenarios are consistently more ethical than group assessments of the same ethical scenarios. Groups consistently viewed questionable actions as more acceptable than individuals and were more likely to say that they or their peers would perform the action. This less ethical perspective persists in future individual ethical assessments, demonstrating a contagion effect on ethical judgments. Furthermore, our results show that justice and relativism are the moral constructs utilized by most participants to form ethical evaluations.

Data Availability: Data are available from the authors.
Impact of Intra-Articular Corticosteroid Injection on Glycemic Control: A Population-Based Cohort Study
Authors: Sytsma Terin T. , Greenlund Laura S. , Fischer Karen M. , McCoy Rozalina G.
Published: August 2023

This retrospective cohort study investigated the longer-term hyperglycemic effects of intra-articular corticosteroid (IACS) administration by evaluating changes in A1C after large joint IACS injection. Among 1,169 patients (mean age 66.1 ± 12.2 years, 52.8% female), 184 (15.7%) experienced a greater-than-expected rise in A1C (actual A1C ≥0.5% above predicted) after IACS. Greater-than-expected rise in A1C was associated solely with baseline A1C (odds ratio [OR] 1.84, 95% CI 1.08–3.13 for baseline A1C of 7.0–8.0% compared with <7.0% and OR 4.79, 95% CI 2.83–8.14 for baseline A1C >8.0% compared with <7.0%). Although most patients do not experience an increase in A1C after IACS, clinicians should counsel patients with suboptimally controlled diabetes about risks of further hyperglycemia after IACS administration.
Reversal of Experimental Autoimmune Diabetes With an sCD39/Anti-CD3 Treatment
Authors: Fotino Carmen , Molano R. Damaris , Ben Nasr Moufida , Umland Oliver , Fraker Christopher A. , Ulissi Ulisse , Balasubramanian Hari Baskar , Lunati Maria Elena , Usuelli Vera , Seelam Andy Joe , Khalefa Salma Ayman , La Sala Christian , Gimeno Jennifer , Mendez Armando J. , Ricordi Camillo , Bayer Allison L. , Fiorina Paolo , Pileggi Antonello
Published: August 2023

Extracellular (e)ATP, a potent proinflammatory molecule, is released by dying/damaged cells at the site of inflammation and is degraded by the membrane ectonucleotidases CD39 and CD73. In this study, we sought to unveil the role of eATP degradation in autoimmune diabetes. We then assessed the effect of soluble CD39 (sCD39) administration in prevention and reversal studies in NOD mice as well as in mechanistic studies. Our data showed that eATP levels were increased in hyperglycemic NOD mice compared with prediabetic NOD mice. CD39 and CD73 were found expressed by both α- and β-cells and by different subsets of T cells. Importantly, prediabetic NOD mice displayed increased frequencies of CD3+CD73+CD39+ cells within their pancreata, pancreatic lymph nodes, and spleens. The administration of sCD39 into prediabetic NOD mice reduced their eATP levels, abrogated the proliferation of CD4+- and CD8+-autoreactive T cells, and increased the frequency of regulatory T cells, while delaying the onset of T1D. Notably, concomitant administration of sCD39 and anti-CD3 showed a strong synergism in restoring normoglycemia in newly hyperglycemic NOD mice compared with monotherapy with anti-CD3 or with sCD39. The eATP/CD39 pathway plays an important role in the onset of T1D, and its targeting might represent a potential therapeutic strategy in T1D.

Article Highlights
Obesity Enables NLRP3 Activation and Induces Myocardial Fibrosis via Hyperacetylation of HADHa
Authors: Deng Yan , Liu Xin , Xie Min , Zhao Rui , Ji Liwei , Tang Kuo , Yang Wei , Ou Wei , Xie Maodi , Li Tao
Published: August 2023

Obesity increases the risk of myocardial fibrosis, a pathological change in most heart diseases, but the mechanism has not been fully elucidated. Here, we found that mice with high-fat diet–induced obesity had more severe myocardial fibrosis than control mice under normal and ischemia/reperfusion (I/R) conditions, which could be alleviated by neutralizing antibodies against interleukin (IL)-1β and IL-18, downstream products of the nucleotide-binding oligomerization-like receptor protein 3 (NLRP3) inflammasome, and the NLRP3 inhibitor MCC950. Mechanistically, mitochondrial hyperacetylation in obese mouse hearts recruited apoptosis-associated speck-like protein containing a CARD (ASC) to mitochondria and thus facilitated NLRP3 inflammasome assembly. Acetylation of K255 on hydroxyl-CoA dehydrogenase α subunit (HADHa) was identified to trigger the mitochondrial localization of ASC. Blockade of HADHa-K255 acetylation downregulated mitochondrial ASC, suppressed the NLRP3 inflammasome, and attenuated post-I/R myocardial fibrosis in obese mouse hearts. In obese human patients, the extent of myocardial fibrosis according to T1 MRI was positively correlated with the plasma levels of IL-1β and IL-18, supporting the connection of NLRP3 inflammation to obesity-induced myocardial fibrosis. In conclusion, our study demonstrates that the heart is susceptible to fibrosis under obesity through hyperacetylated HADHa-mediated activation of the NLRP3 inflammasome.

Article Highlights
Age at type 2 diabetes diagnosis and cause–specific mortality: Observational study of primary care patients in England
Authors: Barker Mary M , Davies Melanie J. , Sargeant Jack  A. , Chan Juliana CN , Gregg Edward W. , Shabnam Sharmin , Khunti Kamlesh , Zaccardi Francesco
Published: August 2023

Objective: To examine the associations between age at type 2 diabetes diagnosis and the relative and absolute risk of all–cause and cause–specific mortality in England.

Research Design and Methods: In this cohort study using primary care data from the Clinical Practice Research Datalink, we identified 108,061 individuals with newly diagnosed type 2 diabetes (16-50 years of age), matched to 829,946 individuals without type 2 diabetes. We estimated all–cause and cause–specific mortality (cancer, cardiorenal, other [noncancer/cardiorenal]) by age at diagnosis, using competing risk survival analyses adjusted for key confounders.

Results: Comparing individuals with vs without type 2 diabetes, the relative risk of death decreased with an older age at diagnosis: the hazard ratio for all–cause mortality was 4.32 (95% CI: 3.35 to 5.58) in individuals diagnosed at 16–27 years compared to 1.53 (1.46 to 1.60) at 48–50 years. Smaller relative risks by increasing age at diagnosis were also observed for cancer, cardiorenal, and noncancer/cardiorenal death. Irrespective of age at diagnosis, the 10–year absolute risk of all–cause and cause–specific mortality was higher in individuals with type 2 diabetes; yet, the absolute differences were small.

Conclusions: Although the relative risk of death in individuals with vs without type 2 was higher at younger ages, the 10–year absolute risk of all investigated causes of death was small and similar in the two groups. Further multidecade studies could help estimate the long-term risk of complications and death in individuals with early-onset type 2 diabetes.
Reversal of experimental autoimmune diabetes with a sCD39/anti-CD3 treatment
Authors: Fotino Carmen , Damaris Molano R. , Ben Nasr Moufida , Umland Oliver , A. Fraker Christopher , Ulissi Ulisse , Baskar Balasubramanian Hari , Elena Lunati Maria , Usuelli Vera , Joe Seelam Andy , Ayman Khalefa Salma , La Sala Christian , Gimeno Jennifer , J. Mendez Armando , Ricordi Camillo , L. Bayer Allison , Fiorina Paolo , Pileggi Antonello
Published: August 2023

Extracellular (e)ATP, a potent pro-inflammatory molecule, is released by dying/damaged cells at the site of inflammation and it is degraded by the membrane ectonucleotidases CD39 and CD73. In this study, we sought to unveil the role of eATP degradation in autoimmune diabetes, we then assessed the effect of soluble CD39 (sCD39) administration in prevention and reversal studies in NOD mice as well as in mechanistic studies. Our data showed that eATP levels were increased in hyperglycemic NODs as compared to pre-diabetic NODs. CD39 and CD73 were found expressed by both α- and β-cells and by different subsets of T-cells. Importantly, pre-diabetic NOD mice displayed increased frequencies of CD3+CD73+CD39+ cells within their pancreata, pLNs and spleens. The administration of sCD39 into pre-diabetic NODs reduced their eATP levels, abrogated the proliferation of CD4+- and CD8+-autoreactive T-cells and increased the frequency of Tregs; while delaying the onset of T1D. Notably, concomitant administration of sCD39 and anti-CD3 showed a strong synergism in restoring normoglycemia in newly hyperglycemic NOD mice as compared to monotherapy with anti-CD3 or with sCD39. The eATP/CD39 pathway plays an important role in the onset of T1D and its targeting might represent a potential therapeutic strategy in T1D.
Sustitución parcial de la harina de trigo (Triticun aestivum L.) por harina de chocho (Lupinus mutabilis) en la elaboración de galletas
Authors: Cabrera Mera Victor Jhoel , Benavides Panchana Jennifer Ivana , Cortez Espinoza Andrea Cristina , Aldas Morejon Jhonnatan Placido , Revilla Escobar Karol Yannela
Published: August 2023

Las galletas son un producto del área de panificación elaborados generalmente con harina de trigo industrial. El objetivo de la presente investigación consistió en evaluar la incidencia de la sustitución parcial de la harina de trigo (Triticun aestivum L.) por la harina de chocho (Lupinus mutabilis) en la elaboración de galletas y cómo influye en las características texturales, fisicoquímicas y sensoriales. Se aplicó un diseño completo al azar (D.C.A) y para determinar diferencia significativa se utilizó la prueba de Tukey (p < 0,05). Todos los tratamientos arrojaron diferencias estadísticas, estableciendo valores para las variables analizadas: dureza (29,89 - 19,04 N), fracturabilidad (0,49 a 0,24 KgF), humedad (4,83 - 2,93 %), proteína (21,65 - 8,16 %), cenizas (2,28 - 1,57 %), fibra cruda (9,38 - 4,39 %), grasa (26,25 - 37,12 %), carbohidratos (59,49 a 25,57 %) y energía (563,00 – 506,6 kcal). En relación con el perfil sensorial, el T4 (25 % de harina de chocho + 75 % de harina de trigo) obtuvo mejor aceptación por parte de los catadores, así como también, un mejor olor, color, sabor y crujencia. Se concluye que la incorporación de harina de chocho en la formulación de galletas es una excelente alternativa para disminuir la dependencia del trigo en su elaboración, siendo también una fuente de alto valor nutricional.
Forecasting Non-Oil and Gas Exports in Indonesia Using Double and Triple Exponential Smoothing Methods
Authors: Bustami  , Yolanda Anne Mudya , Thahira Nisha
Published: August 2023

Non-oil and gas exports could be forecasted using exponential smoothing for future periods. This study examines non-oil and gas export data in Indonesia from January 2015 to May 2021, indicating trends and seasonality. Based on the data characteristics, the obtained data were analyzed using Holt's double exponential smoothing method and triple exponential smoothing with multiplicative and additives Holt-Winters. The MAPE for all three models is less than 10%, indicating that the method is very good and could be used to forecast the next period. Using MAPE as a comparison, the best model for non-oil and gas exports is the additive Holt-Winters method triple exponential smoothing, which has the lowest MAPE of any model. The best method was employed to forecast data, making it possible for us to anticipate the pattern of non-oil and gas exports. This forecast data could be used as the basis for policymakers' decision-making. The forecast results using this method indicate that the value of non-oil exports will increase for the next period.
Physical and Sensory Properties of Bread and Roti Made from Rice-Wheat Composite Flour
Authors: Singh Narita , Singh Dharamdeo , Daynauth Roland , Dalrymple Nequesha , Persaud Rajendra , Persaud Bissessar
Published: August 2023

Guyana is targeting a reduction in its food import bill by substituting wheat, a major food commodity imported, with locally grown crops. In this study, the physical and sensory characteristics of value-added products (bread and roti) made from various ratios of rice-wheat composite flour were examined to ascertain whether rice flour might be successfully used to partially replace wheat flour. Bread and roti were produced from rice-wheat composite flours at rice:wheat ratios of 0:100, 20:80, 40:60, 60:40, and 80:20. Physical evaluation showed significant differences in the width, height, weight, and volume of bread produced from the composite rice-wheat flour and the control (p≤0.05). Significant differences were also observed for the thickness and weight of the roti (p=0.005 and p= 0.024 respectively). There were no significant differences in the length among treatments for both bread and roti (p=0.74 and p=0.10, respectively). The length, height, weight and volume of bread and the length, thickness and weight of roti produced from 20% rice flour+80% wheat flour was statistically similar with the control (100% wheat) treatments (p>0.05). For the sensory evaluation, there were significant differences for all attributes evaluated including aroma, colour, texture, taste, and overall acceptance (p=0.001). Sensory attributes for bread treatments made from 20% rice flour+80% wheat flour and roti treatments made from 20% rice flour+80% wheat flour and 40%rice flour+60% wheat flour was similar to the control (p>0.05). The study revealed that substituting 20% of wheat flour with rice flour in products such as bread and roti is possible without compromising the quality and sensory characteristics of the products.
La Patagonia Rebelde en la prensa porteña
Authors: Zubimendi Miguel Ángel
Published: August 2023

En el trabajo se analiza el modo en el que los diarios comerciales La Nación y La Prensa, y el diario anarquista La Protesta informaron sobre las huelgas que ocurrieron en el territorio de Santa Cruz, Argentina, durante 1921, conocidas comúnmente como La Patagonia Rebelde. Se describe y se compara qué fuentes utilizaron, cómo presentaron los sucesos y cómo analizaron las consecuencias. Se comprobó que cada periódico le habló a su público según sus intereses: la defensa del orden amenazado, en el caso de los comerciales; y la reivindicación y la memoria, en el caso del diario anarquista.
A Comparative Study of Motion Feature Recognition under Different Learning Methods
Authors: Zhou Shuang
Published: August 2023

The accurate analysis and prediction of human motion posture can provide effective data support for sports training. With the continuous progress of computer science and technology and the gradual maturity of artificial intelligence technology, there is still some controversy about the recognition effect of motion features under different algorithms. Therefore, this paper compares the recognition effects of different learning methods, including two machine learning methods by using k-means classification, such as SVM and a deep learning method CNN. The motion data of three basic movements, such as running, jumping and turning, are collected and their feature information is extracted by sensor equipment. The recognition effect is compared with the overall accuracy rate as the evaluation index. Among them, when k-means classification is used, through feature extraction and selection, the final combination of mean and variance features is obtained and applied to SVM. When CNN is adopted, its performance can be optimised by adjusting its network structure and some super parameters in the convolution layer and pool layer.
Mathematical model on Type 1 diabetes and Healthy state: Mechanisms of β cells on the interaction between M1 and M2 Macrophages
Authors: Hamam Haneen
Published: August 2023

Type 1 diabetes (T1D) is a chronic autoimmune disease caused by the immune-mediated reduction of β cells, resulting in lifelong dependence on exogenous insulin administration. We studied the impact of M1/M2 macrophages on the β cell level. We obtained the healthy state (absence of T1D) and unhealthy state (presence of T1D). We found that in the unhealthy state, β cell levels are decreased with a continuous alternative switch between M1 and M2 macrophages. However, in the healthy state, the β cell levels increase with a high level of M2 macrophages.
La expansión de la soya y la conservación de agua y ambiente en Campeche
Authors:   Instituto Mexicano de Tecnología del Agua, Pedrozo Acuña Adrian
Published: August 2023

El IMTA aporta el mejor conocimiento disponible en el mundo con el fin de conservar la salud del medio ambiente y garantizar el acceso a agua segura para toda la población.
The Threat of Social Network Games in Indonesia
Authors: Sandy  , Andoko Djoko , Setiawati Nurisnaeny Poppy , Murniasari Mira
Published: August 2023

This research examines the potential threat through SNG in Indonesia. The theories of threat, social media, cyber, and network society are used to analyze the research problem through qualitative analysis. Data was obtained through interviews and literature studies. The results of the study show that the potential threat on SNG includes ideological threats in society, growing illegal and pornographic content, theft of personal data, illegal monitoring of user activities, online fraud, cyberbullying, inappropriate content, dependence, and cyber attacks that threaten the activities of social network game users in Indonesia.
The adverse and favorable obstetrical outcomes following bariatric surgery, retrospective study at King Abdulaziz University Hospital, Jeddah, Saudi Arabia
Authors: Sabban Hussein , AlSwealh Salma , Fasehaldeen Sara , Alwafi Sulafa , Althagafi Lama , AlSwealh Maab , Bouges Raghad , Alamoudi Albatoul , Bali Dana
Published: August 2023

Background: Obesity poses a substantial health burden globally, increasing the risk of adverse maternal and perinatal outcomes in reproductive-age females. This study aimed to investigate the impact of bariatric surgery on adverse maternal outcomes in Jeddah, Saudi Arabia.
Methods: A retrospective single-center study was conducted at King Abdulaziz University Hospital, Jeddah, Saudi Arabia, between 2020 and 2023. The study included 48 out of 438 individuals aged 18-45, who underwent bariatric surgery and subsequently became pregnant. Exclusion criteria comprised patients with primary endometriosis, family history of infertility, uterine fibroids, endometrial tuberculosis, or incomplete data. Data related to the first pregnancy after bariatric surgery were collected and analyzed.
Results: Among the 48 females studied, pregnancy complications included maternal anemia (54.2%), vitamin D insufficiency (35.4%), gestational diabetes (8.3%), and pregnancy-induced hypertension (4.2%). Modes of delivery comprised spontaneous vaginal delivery (62.5%), miscarriage (33.3%), and cesarean section (22.9%). The mean number of pregnancies after bariatric surgery was 1.58 ± 0.89, the mean age of patients after the first child's birth post-bariatric surgery was 33.31 ± 5.54 years, the mean duration between bariatric surgery and conception was 4.05 ± 2.49 years, and the mean weight before pregnancy and weight gain during pregnancy were 67.69 ± 15.55 kg and 10.74 ± 683 kg, respectively. The mean weeks of gestation were 37.4 ± 4.51.
Conclusion: This study highlights a significant relationship between bariatric surgery and the duration of conception. However, no significant association was observed between the type of bariatric surgery and pregnancy complications, mode of delivery, or outcome of the first pregnancy post-surgery. Further research is warranted to investigate the heterogeneity of bariatric surgeries by comparing their types and their effects on pregnancy and neonatal outcomes.
PLANTAS DE COBERTURA E SEUS EFEITOS NOS ATRIBUTOS DO SOLO E PARA A CULTURA DO FEIJÃO-CAUPI EM RORAINÓPOLIS
Authors: Costa Raquel da Silva , Silva João José Costa , Barros Danieli Lazarini de , Silva Lelisângela Carvalho da , Gomide Plínio Henrique Oliveira
Published: August 2023

A utilização de adubos verdes, como cobertura vegetal viva ou morta, promove o controle da erosão, reduz a lixiviação de nutrientes, melhora os atributos físicos, químicos e biológicos, proporcionando melhores condições ao solo para que as espécies possam exercer as funções e, possivelmente, aumento de produtividade. O experimento será realizado em Rorainópolis, em área experimental da UERR. Serão coletadas amostras de solo da camada de 0 – 20 cm para análises físicas e químicas. Serão utilizadas quatro espécies de plantas de cobertura, considerando-se algumas características inerentes a cada adubo verde, tais como: resistência à baixa fertilidade, ciclo curto, crescimento rápido e boa produção de biomassa. Após 20 dias do corte dos adubos, uma nova coleta de solo da camada 0 - 20 cm será realizada por parcela. Após o corte será semeado o feijão-caupi sobre as palhas produzidas pelas plantas de cobertura. Serão avaliadas características do feijoeiro, como: estande final, altura de plantas, peso seco da parte aérea, número de vagens por planta, número de grãos por vagem, peso médio de 100 grãos e rendimento de grãos. O delineamento experimental será o de blocos casualizados, com 3 repetições em esquema fatorial (4 x 2) + 1 composto pelos adubos verdes, dois espaçamentos entre linhas (25 cm e 50 cm), e testemunha como tratamento adicional. O objetivo do trabalho é estimar a produção de fitomassa e o acúmulo de nutrientes produzida por plantas de cobertura e seus efeitos para cultura do feijão-caupi bem como nas características químicas e físicas do solo.
Impactos de la tasa representativa de mercado empleando modelos estadísticos, estudio sectorial
Authors: Merchan Jiménez Leidy Bibiana , Restrepo Quiroz Jorge Andrés , Valencia Cárdenas Marisol , Caridad Faria Migdalia Josefina
Published: August 2023

La afectación en los costos y rentabilidad del negocio porcino a partir del dólar es una realidad que afecta a la economía. En este trabajo se evalúan los efectos de la Tasa Representativa del Mercado (TRM) sobre variables financieras del sector porcícola en Colombia, como los costos y el margen de utilidad del sector. Se emplea una metodología de investigación cuantitativa con enfoque correlacional, mediante pruebas de correlación de Pearson, así como modelos estadísticos, estimando los efectos de la TRM sobre el margen de utilidad y modelos de pronóstico de la TRM. Se encuentra una alta volatilidad en la TRM, además, la correlación y alta asociación con la mayoría de los costos no se puede negar, lo cual es muestra de una afectación negativa frente al margen en especial, cuando aumenta la TRM. El modelo de pronóstico de la TRM considera términos correlacionados con su propio pasado, estimando un Arima para los residuales.
Os desafios da psiquiatria
Authors: Tamai Sérgio , Allevato Marcelo
Published: August 2023

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Psiquiatria forense
Authors: Telles Lisieux Elaine de Borba , Mecler Katia
Published: August 2023

A Psiquiatria forense é o tema tratado nessa discussão proporcionada pela ABP TV. Os psiquiatras forenses são especialistas certificados que trabalham com casos que envolvem a lei.
Esquizofrenia
Authors: Elkis Hélio , Louzã Neto Mario Rodrigues
Published: August 2023

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Transtornos de personalidade, comportamento violento e imputabilidade penal
Authors: Valença Alexandre Martins , Telles Lisieux Elaine de Borba , Rigonatti Luiz Felipe
Published: August 2023

Os transtornos de personalidade são definidos como padrões persistentes no modo de pensar, agir, reagir, sentir e se relacionar do indivíduo que os prejudicam nas relações interpessoais, causando sofrimento e comprometimento funcional. Entre os transtornos mais conhecidos estão o antissocial, borderline, narcisista e psicopatia. Toda pessoa que possui transtorno de personalidade é violenta? Toda pessoa que comete crime e tem transtorno de personalidade é inimputável? Toda pessoa que possui um transtorno de personalidade cometerá um crime?
The Impact of U.S. Policy on Political Change in the Middle East: Afghanistan Political Change in as a Model
Authors: Assist.Prof.Dr. Raed Irhaim Muhammed
Published: August 2023

The events witnessed in the Middle East and the study of U.S. foreign policy and its hostility towards various countries, particularly in the context of terrorism and how to address and implement it, can potentially lead to an increase in terrorist activities. The approach adopted by most U.S. presidents in the Middle East region revolves around ensuring access to oil and preventing the spread of nuclear weapons in these countries. The Americans have been present in Afghanistan for over 20 years and have spent substantial amounts of money, yet the intentions and objectives of the Taliban remain unclear to them and the international community.

This prolonged presence has caused security, political, and economic instability in Afghanistan, leading to unpredictable consequences in the country and fears of a potential resurgence of terrorism in the future. The aftermath of the U.S. withdrawal could potentially result in significant and diverse changes, with the possibility of a civil war within Afghanistan, which poses future risks and threats for both the country and the international community.
Modeling and Dynamic Stability Analysis of Distributed Electric Propulsion Tilt-Rotor UAV
Authors: Zhao Qingfeng , Zhou Zhou , Zhang Zhilin
Published: August 2023

Distributed electric propulsion tilt-rotor unmanned aerial vehicles (TRUAVs) with a lift-increasing flap in the propulsion wake have better aerodynamic efficiency than traditional tilt-rotor unmanned aerial vehicles and better takeoff/landing capacity than fixed-wing aircraft. However, for this configuration, establishing the propulsion–aerodynamic coupling model between the flap and the duct is difficult. This paper presents a flight dynamics model with propulsion–aerodynamic coupling components and analyzes dynamic characteristics during the transition period for TRUAVs with a distributed-propulsion/flap configuration. The development of the flight dynamics model considers the descriptions of the duct model, the lift-increasing flap model, and the propeller model. The model of the lift-increasing flap in both the duct exhaust jet and the freestream is the key component of the vehicle dynamics equations and is validated with experimental data and computational fluid dynamics results. Based on the dynamics model, the transition corridor of the tilt-rotor aircraft with multiple asynchronous tilting components and a geometrical constraint is calculated and analyzed. Additionally, the longitudinal dynamics stability of the aircraft in different flight speeds and configurations is assessed based on the numerical differentiation method. The results showed that the vehicle flight speed has more influence on longitudinal short-period stability than the angle of attack (AOA) of the flap. Also, the longitudinal long-period stability is affected by both the vehicle flight speed and the AOA of the flap. Finally, a mathematical derivation is developed to analyze the aircraft’s unstable state. The presented analysis results show that the stability of the long period is affected by the velocity derivative of the fuselage’s lift.
Türkiye İşçi Partisi’nin İnşa ve Gelişimini Tetikleyen Koşullar (1960 – 1966)
Authors: İNAN Erkan
Published: August 2023

Türkiye İşçi Partisi, 1960’lı yıllarda Türkiye siyasetinin önemli bir aktörü olmayı başarmıştır. Türkiye’de sol ideolojinin gelişimine katkı sağlayan birçok kişinin yolları Türkiye İşçi Partisi ile kesişmiştir. Devrimci gençlik önderlerinden edebiyatçılara, teorisyenlerden hukukçulara, işçilerden öğrencilere kadar sol harekete ilgi duyan birçok kesimin önemli temsilcileri Türkiye İşçi Partisi çatısı altında bulunmuşlardır. Peki, Türkiye İşçi Partisi’ni bir çekim merkezi konumuna sürükleyen koşullar neydi? Neden toplumun farklı kesimleri bu örgüt içerisinde yer almak istemişlerdi? Türkiye İşçi Partisi’nin gelişimini tetikleyen koşullar neydi?
Bu çalışmada; Türkiye İşçi Partisi’nin inşa ve gelişiminin temel dinamiklerini oluşturan ulusal ve uluslararası koşulların irdelenmesi amaçlanmaktadır. Türkiye İşçi Partisi’nin inşa süreci ulusal ve uluslararası düzlemde ele alınmaktadır. Türkiye İşçi Partisi ve oluşturmuş oldukları blokların hangi koşullarda ortaya çıktıkları tartışılmaktadır. Türkiye İşçi Partisi’nin kendisini konumlandırmış olduğu politik hat ve bu hattın örgüte sunduğu özgünlük vurgulanan konular arasındadır. Çalışmanın bütününde Türkiye İşçi Partisi’nin hangi koşulların ürünü olduğu sorusuna yanıtlar aranmakta ve bu koşulların örgütün kitleselleşmesindeki rolleri tartışılmaktadır. Yanıt arama sürecinde Türkiye İşçi Partisi’nin politik hattından faydalanılmaktadır. Örgütün konumlanmış olduğu politik hattın reel sosyalizmden keskin farklılıklar içerdiği sonucuna ulaşılmıştır. Türkiye İşçi Partisi bünyesinde yeni bir sosyalizm okuması üzerinden Türkiye’ye özgü bir sosyalizm anlayışı geliştirilmeye çalışılmıştır. Bu çabanın sonucunda Batı demokrasisi ve sosyalizm aynı potada eritilmeye çalışılmış, reel sosyalizm anlayışı reddedilmiştir. Bu çabanın hangi koşulların ürünü olabileceği tartışılmaktadır.
Peptide stereochemistry effects from pKa-shift to gold nanoparticle templating in a supramolecular hydrogel.
Authors: Adorinni Simone , Gentile Serena , Bellotto Ottavia , Kralj Slavko , Parisi Evelina , Cringoli Maria , Deganutti Caterina , Malloci Giuliano , Piccirilli Federica , Pengo Paolo , Vaccari Lisa , Geremia Silvano , Vargiu Attilio , De Zorzi Rita , Marchesan Silvia
Published: August 2023

The divergent supramolecular behavior of a series of tripeptide stereoisomers was elucidated through spectroscopic, microscopic, crystallographic and computational techniques. Only two epimers were able to effectively self-organize into amphipathic structures, leading to supramolecular hydrogels or crystals, respectively. Despite the similarity between the two peptides’ turn conformations, stereoconfiguration led to different abilities to engage in intramolecular hydrogen bonding. Self-assembly further shifted the pKa of the C-terminal side chain. As a result, across the pH range 4-6, only one epimer predominated sufficiently as a zwitterion to reach the critical molar fraction allowing gelation. By contrast, the differing pKa values and higher dipole moment of the other epimer favored crystallization. The four stereoisomers were further tested for gold nanoparticle (Au NP) formation, with the supramolecular hydrogel being key to control and stabilize Au NPs, yielding a nanocomposite that catalyzed the photodegradation of a dye. Importantly, the Au NP formation occurred without the use of reductants other than the peptide, and the redox chemistry was investigated by LC-MS and NMR. This study provides important insights for the rational design of simple peptides as minimalistic and green building blocks for functional nanocomposites.
Orchestrating nimble experiments across interconnected labs
Authors: Guevarra Dan , Kan Kevin , Lai Yungchieh , Jones Ryan , Zhou Lan , Donnelly Phillip , Richter Matthias , Stein Helge , Gregoire John
Published: August 2023

Advancements in artificial intelligence (AI) for science are continually expanding the value proposition for automation in materials and chemistry experiments. The advent of hierarchical decision-making also motivates automation of not only the individual measurements but also the coordination among multiple research workflows. In a typical lab or network of labs, workflows need to independently start and stop operation while also sharing resources such as centralized or multi-functional equipment. A new paradigm in instrument control is needed to realize the combination of independence with respect to periods of operation and interdependence with respect to shared resources. We present Hierarchical Experimental Laboratory Automation and Orchestration with asynchronous programming (HELAO-async), which is implemented via the Python asyncio package by abstracting each resource manager and experiment orchestrator as a FastAPI server. This framework enables coordinated workflows of adaptive experiments, which will elevate Materials Acceleration Platforms (MAPs) from islands of accelerated discovery to the AI emulation of team science.
Bispecific Antibodies Produced via Chemical Site-Specific Conjugation Technology: AJICAP Second Generation
Authors: Fujii Tomohiro , Ito Kenichiro , Takahashi Kazutoshi , Aoki Tsubasa , Seki Takuya , Iwai Yusuke , Takasugi Rika , Watanabe Tomohiro , Hirama Ryusuke , Tsumura Ryo , Fuchigami Hirobumi , Yasunaga Masahiro , Matsuda Yutaka
Published: August 2023

Bispecific antibodies are biotherapeutics that amalgamate the specificities of two distinct antibodies into one molecule. Bispecific antibodies can be utilized in a broad range of diagnostic and therapeutic applications; however, their engineering requires genetic modification and remains time-consuming. Therefore, in this study, we used AJICAP second-generation technology, which drives the production of site-specific antibody-drug conjugates in a practical and robust manner, without genetic modification requirements, to generate bispecific antibodies. Using haloketone chemistry as an alternative to maleimide chemistry, which carries reaction risks, we successfully produced site-specific antibody conjugates. Pharmacokinetic studies revealed that the haloketone-based antibody conjugate was stable in the rat plasma. The resultant bispecific antibodies were rigorously evaluated, and surface plasmon resonance measurements and flow cytometry analyses confirmed that antigen binding remained intact. Additionally, the affinity for the neonatal Fc receptor (FcRn) was retained after conjugation. Further cytotoxicity evaluation emphasized the pronounced activity of the generated bi-specific antibodies. These preliminary findings highlight the potential of AJICAP second-generation technology in BisAb production. This novel approach introduces a fully chemical, site-specific strategy capable of producing bispecific antibodies, heralding a new era in the field of biotherapeutics.
Tetrahedral to Octahedral Nickel(II) as an Initiation Step in Metallaphotoredox Catalysis
Authors: Zieleniewska Anna , Earley Justin , Yu Jin , Kudisch Max , DiLuzio Stephen , Cordones-Hahn Amy , Sayre Hannah , Zhang Xiaoyi , Rumbles Garry , Reid Obadiah
Published: August 2023

In this work we seek to understand the pre-catalytic initiation steps in a classic metallaphotoredox catalysis paring Ir(III) ((Ir[dF(CF$_{3}$)ppy]$_{2}$(dtbbpy))PF$_{6}$) and Ni(II) ((4,4'-dtbbpy)NiCl$_{2}$) in dimethoxyethane. We use a combination of transient X-ray and optical absorption spectroscopies to track both nuclear and electronic excited-state dynamics, revealing two steps. First, photoexcitation produces the expected intramolecular oxidation of the iridium center, Ir(III), to Ir(IV)(dtbbpy)$^{\bullet -}$ correlated to the Ir metal-to-ligand charge transfer state. Second, interaction with Ir(IV)(dtbbpy)$^{\bullet -}$ drives the tetrahedral Ni(II) starting material to an unexpected octahedral Ni(II) species. We conclude by proposing the identity of the octahedral Ni(II) and suggest both an electron and an energy transfer mechanism for producing it that are equally consistent with our observations.
COVID-19 en la comunidad campesina de Ñuñungayocc – Huancavelica, 2020
Authors: Huamán Pérez Francisca , Poma Castellanos Gualberto , Churampi Cangalaya Roberto Lider
Published: August 2023

El objetivo general del presente artículo es explicar las consecuencias del COVID-19 en las familias en la comunidad campesina de Ñuñungayocc-Huancavelica en el 2020. El método empleado fue el científico e inductivo, tipo de investigación es básica, de enfoque cualitativo, nivel descriptivo y diseño etnográfico. Los informantes claves fueron diez comuneros (calificados y no calificados), las técnicas de acopio de la data fueron el análisis documental, entrevistas y observación. El resultado al que se arribó es que la pandemia generada por el COVID-19 irrumpió la tranquilidad de los espacios rurales; Ñuñungayocc es una zona considerada como pobre, con hogares que viven de la productividad comunal. Muchos de los que retornaron a Ñuñungayocc, han sido personas que perdieron sus trabajos (comercio informal), fueron despedidos (empleos en pequeñas fabricas), en general personas que no contaban con vivienda propia. Este retorno significó muchos cambios en la comunidad, ha interrumpido la tranquilidad del territorio comunal, acceso a recursos, y en cuanto a salud, se han presentado enfermedades respiratorias y contagios, que terminaron en decesos de muchos comuneros naturales de la zona.
Finalmente, la conclusión consiste en que El COVID-19 generó el retorno de emigrantes de las ciudades como Lima, Huancayo y Huancavelica interrumpiendo la tranquilidad del territorio comunal, Posteriormente muchos de las familias complicándose en su salud y decesos en la comunidad campesina, realizando el tratamiento con la sapiencia ancestral y convencional.
Marketing Digital (MD) en Empresas Turísticas de la Región Centro del Perú (RCP)
Authors: Orihuela Ponciano Andrea Soledad , Paredes Pérez Marco Antonio José , Palomino Crispin Antonio Eleodoro , Rojas Guere Oscar Raúl
Published: August 2023

El objetivo del estudio fue determinar la percepción del nivel de uso del marketing digital en colaboradores de empresas turísticas de la región del Centro del Perú. El enfoque de investigación fue cuantitativo, diseño del estudio fue no experimental transversal descriptivo, el nivel de la investigación fue descriptivo, desarrollado en base a la perspectiva de Selman (2017) el cual tuvo 12 ítems, las dimensiones fueron flujo funcionalidad, feedback y fidelización, la muestra estuvo conformada por 13 empresas turísticas, de las cuelas se encuestaron a 120 colaboradores. El resultado principal fue que los establecimientos turísticos en la regios central del Perú hacen un uso medio del marketing digital como estrategia empresarial.
Separating the Wrong of Settlement from the Right to Exclude
Authors: Guillery Daniel Alexander
Published: August 2023

Recent philosophical work on settler colonialism has attempted to account for the distinctive wrong in these practices in terms of the violation of exclusionary territorial rights held by inhabitants of colonised areas. If it turns out that such rights are needed to account for this distinctive wrong, that appears to be a significant cost for views sceptical of territorial rights. This paper sets out to explore the possibility of accounting for this wrong without invoking exclusionary territorial rights and puts forward an account of sociocultural stability rights that allow us to do so (thereby indirectly supporting sceptical views of territorial rights).
RELAÇÕES E REFLEXÕES SOBRE ETNOCIÊNCIA E ETNOMATEMÁTICA EM SALA DE AULA
Authors: Araújo Lucas Pereira de , Mariano Wagner dos Santos , Costa Dailson Evangelista , Melo Elisângela Aparecida Pereira de
Published: August 2023

Este trabalho apresentar a interligação entre duas disciplinas inseridas no contexto "etno-x", que unem os saberes populares e os conhecimentos científicos. O estudo é guiado pela pergunta norteadora: Quais relações podem ser identificadas entre a Etnociência e a Etnomatemática, que viabilizam o ensino das ciências em ambiente escolar? Nesse sentido, esta pesquisa objetiva identificar elementos que conectam a Etnociência e a Etnomatemática, permitindo a integração do ensino das ciências no ambiente escolar. Trata de um ensaio teórico com abordagem qualitativa no âmbito de discussões conceituais e características relativas às abordagens “etno-x”. Os resultados indicam três pontos cruciais de interconexão entre a Etnociência e a Etnomatemática, que emergem do estudo: a interdisciplinaridade, a abordagem transversal e a incorporação dos saberes populares e da cultura nas práticas educacionais voltadas para as Ciências.
Postharvest quality evaluation on the hot water-dipped Zingiber officinale
rhizomes stored at low-temperature storage
Authors: Shukor N.I.A. , Misran A. , Saari N. , Ahmad S.H. , Mahmud T.M.M.
Published: August 2023

Storing ginger at chilling temperature will reduce its postharvest quality as they are prone
to chilling injury (CI). Therefore, a study on hot-water dip treatment in alleviating CI in
'Bentong' ginger rhizome on physical and chemical properties was conducted. Fresh
ginger rhizomes were harvested in the 9th month after planting. The fresh and cleaned
rhizomes were hot-water treated at 45°C for 0, 5, 10 and 15 mins before being packed in a
box and stored at 5°C for 0, 8 and 16 days. There was a significant interaction effect
between dipping and storage durations on the physical and chemical properties of the
rhizome. Exposed rhizome for 5, 10 and 15 mins was observed to maintain the ho
and L*
of the rhizome after storage at 5°C. The decreases in h° from yellow to slightly brown also
indicated rhizome browning. Rhizome held at 45°C for 5 mins managed to reduce
browning as compared to other durations. In addition, dipping for 15 mins resulted in a
significant increase in total phenolic content, total flavonoid content and 6-gingerols.
While 6-shogaols was maintained at 45°C for 5 mins. Preconditioning by the hot-water
treatment could induce chilling tolerance upon storage at chilling temperature.
O Agronegócio e sua relação com o crescimento econômico de uma região do Matopiba: um estudo aplicado no Tocantins no período de 2003-2018
Authors: Rodrigues Sobrinho William Brasil , Aragão Joaquim José Guilherme de , Bracarense Lilian dos Santos Fontes Pereira Bracarense
Published: August 2023

Por meio de uma abordagem com dados em painel dos 139 municípios do estado do Tocantins, o presente artigo tem o objetivo de evidenciar o impacto do agronegócio e sua contribuição para o crescimento econômico, no período de 2003-2018. O trabalho contribui para a literatura ao apresentar a evolução do agronegócio e o impacto do setor em uma região inserida no Matopiba e, ainda estabeleceu um status quo do cenário do agronegócio no estado do Tocantins. Entre os principais resultados do estudo é possível indicar que, de modo geral, o agronegócio contribuiu positivamente para o crescimento econômico do estado do Tocantins.
Screening and simultaneous determination of 80 veterinary drugs residues in food by HPLC-MS/MS
Authors: Amelin V. G. , Batov I. V. , Lavrukhina O. I. , Tretyakov A. V. , Kish L. K.
Published: August 2023

A fast method of samples screening and determination of 80 veterinary drugs residues in food safety assessment is proposed. The solid-phase extraction for the extract purification in the sample preparation is excluded, at the same time the matrix effect is mitigated by the isotope-labeled standards using. The isotope dilution method allowed to exclude matrix calibration curves construction and calculate the concentration using correction coefficients found from analytes standard aqueous solutions and a limited number of isotope-labeled standards. The drugs residues limits of detection (cmin = 0,1 – 10 ng/g) allowed their determination at the maximum permissible levels for food.