bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effects of Breastfeeding on Retinoblastoma Development: Results from an International Multicenter Retinoblastoma Survey
Authors: Randhawa Jasmeen K. , Kim Mary E. , Polski Ashley , Reid Mark W. , Mascarenhas Kristen , Brown Brianne , Fabian Ido Didi , Kaliki Swathi , Stacey Andrew W. , Burner Elizabeth , Sayegh Caitlin S. , Poblete Roy A. , Ji Xunda , Zou Yihua , Sultana Sadia , Rashid Riffat , Sherief Sadik Taju , Cassoux Nathalie , Garcia Juan , Coronado Rosdali Diaz , López Arturo Manuel Zapata , Ushakova Tatiana , Polyakov Vladimir G. , Roy Soma Rani , Ahmad Alia , Reddy M. Ashwin , Sagoo Mandeep S. , Al Harby Lamis , Astbury Nicholas John , Bascaran Covadonga , Blum Sharon , Bowman Richard , Burton Matthew J. , Gomel Nir , Keren-Froim Naama , Madgar Shiran , Zondervan Marcia , Berry Jesse L.
Published: September 2021

The protective effects of breastfeeding on various childhood malignancies have been established but an association has not yet been determined for retinoblastoma (RB). We aimed to further investigate the role of breastfeeding in the severity of nonhereditary RB development, assessing relationship to (1) age at diagnosis, (2) ocular prognosis, measured by International Intraocular RB Classification (IIRC) or Intraocular Classification of RB (ICRB) group and success of eye salvage, and (3) extraocular involvement. Analyses were performed on a global dataset subgroup of 344 RB patients whose legal guardian(s) consented to answer a neonatal questionnaire. Patients with undetermined or mixed feeding history, family history of RB, or sporadic bilateral RB were excluded. There was no statistically significant difference between breastfed and formula-fed groups in (1) age at diagnosis (p = 0.20), (2) ocular prognosis measures of IIRC/ICRB group (p = 0.62) and success of eye salvage (p = 0.16), or (3) extraocular involvement shown by International Retinoblastoma Staging System (IRSS) at presentation (p = 0.74), lymph node involvement (p = 0.20), and distant metastases (p = 0.37). This study suggests that breastfeeding neither impacts the sporadic development nor is associated with a decrease in the severity of nonhereditary RB as measured by age at diagnosis, stage of disease, ocular prognosis, and extraocular spread. A further exploration into the impact of diet on children who develop RB is warranted.
Continued versus Interrupted Targeted Therapy during Metastasis-Directed Stereotactic Radiotherapy: A Retrospective Multi-Center Safety and Efficacy Analysis
Authors: Kroeze Stephanie G. C. , Fritz Corinna , Schaule Jana , Blanck Oliver , Kahl Klaus Henning , Kaul David , Siva Shankar , Gerum Sabine , Claes An , Sundahl Nora , Adebahr Sonja , Stera Susanne , Schymalla Markus M. , Abbasi-Senger Nasrin , Buergy Daniel , Geier Michael , Szuecs Marcella , Lohaus Fabian , Henke Guido , Combs Stephanie E. , Guckenberger Matthias
Published: September 2021

The increasing use of targeted therapy (TT) has resulted in prolonged disease control and survival in many metastatic cancers. In parallel, stereotactic radiotherapy (SRT) is increasingly performed in patients receiving TT to obtain a durable control of resistant metastases, and thereby to prolong the time to disseminated disease progression and switch of systemic therapy. The aims of this study were to analyze the safety and efficacy of SRT combined with TT in metastatic cancer patients and to assess the influence of continuous vs. interrupted TT during metastasis-directed SRT. The data of 454 SRTs in 158 patients from the international multicenter database (TOaSTT) on metastatic cancer patients treated with SRT and concurrent TT (within 30 days) were analyzed using Kaplan–Meier and log rank testing. Toxicity was defined by the CTCAE v4.03 criteria. The median FU was 19.9 mo (range 1–102 mo); 1y OS, PFS and LC were 59%, 24% and 84%, respectively. Median TTS was 25.5 mo (95% CI 11–40). TT was started before SRT in 77% of patients. TT was interrupted during SRT in 44% of patients, with a median interruption of 7 (range 1–42) days. There was no significant difference in OS or PFS whether TT was temporarily interrupted during SRT or not. Any-grade acute and late SRT-related toxicity occurred in 63 (40%) and 52 (33%) patients, respectively. The highest toxicity rates were observed for the combination of SRT and EGFRi or BRAF/MEKi, and any-grade toxicity was significantly increased when EGFRi (p = 0.016) or BRAF/MEKi (p = 0.009) were continued during SRT. Severe (≥grade 3) acute and late SRT-related toxicity were observed in 5 (3%) and 7 (4%) patients, respectively, most frequently in patients treated with EGFRi or BRAF/MEKi and in the intracranial cohort. There was no significant difference in severe toxicity whether TT was interrupted before and after SRT or not. In conclusion, SRT and continuous vs. interrupted TT in metastatic cancer patients did not influence OS or PFS. Overall, severe toxicity of combined treatment was rare; a potentially increased toxicity after SRT and continuous treatment with EGFR inhibitors or BRAF(±MEK) inhibitors requires further evaluation.
Model of Social Support for Patients Treated for Cancer
Authors: Pasek Małgorzata , Suchocka Lilia , Gąsior Krzysztof
Published: September 2021

Social support can be one of the main factors in better assessing the quality of life at any stage of the recovery process. It should meet the patient’s needs so that they can develop constructive methods of coping with the disease. In order to explain the factors influencing social support for cancer patients, a theoretical research model was formulated. It is presented in a graphic form in this article. In order to verify the model, the authors’ questionnaire and other standardised questionnaires were used. The experimental group consisted of 170 hospitalised oncological patients being treated for cancer. Personality structure, through its relationship with state of health (0.40) and attitude developed to the disease (0.64), influenced the support experienced by the treated patients (0.40). The surveyed patients, who were characterised by positive self-esteem and experience of life satisfaction despite various difficult situations, perceived to a greater degree the emotional and instrumental support provided to them. During cancer treatment, those patients who showed a need for help and did not experience negative emotions were characterised by an increased need for support. The research results can be introduced into evidence-based medical practice, which could significantly improve the quality of nursing and medical care for patients.
Keeping Myeloma in Check: The Past, Present and Future of Immunotherapy in Multiple Myeloma
Authors: Ackley James , Ochoa Miguel Armenta , Ghoshal Delta , Roy Krishnendu , Lonial Sagar , Boise Lawrence H.
Published: September 2021

Multiple myeloma is an incurable disease of malignant plasma cells and an ideal target for modern immune therapy. The unique plasma cell biology maintained in multiple myeloma, coupled with its hematological nature and unique bone marrow microenvironment, provide an opportunity to design specifically targeted immunotherapies that selectively kill transformed cells with limited on-target off-tumor effects. Broadly defined, immune therapy is the utilization of the immune system and immune agents to treat a disease. In the context of multiple myeloma, immune therapy can be subdivided into four main categories: immune modulatory imide drugs, targeted antibodies, adoptive cell transfer therapies, and vaccines. In recent years, advances in all four of these categories have led to improved therapies with enhanced antitumor activity and specificity. In IMiDs, modified chemical structures have been developed that improve drug potency while reducing dose limiting side effects. Targeted antibody therapies have resulted from the development of new selectively expressed targets as well as the development of antibody drug conjugates and bispecific antibodies. Adoptive cell therapies, particularly CAR-T therapies, have been enhanced through improvements in the manufacturing process, as well as through the development of CAR constructs that enhance CAR-T activation and provide protection from a suppressive immune microenvironment. This review will first cover in-class breakthrough therapies for each of these categories, as well as therapies currently utilized in the clinic. Additionally, this review will explore up and coming therapeutics in the preclinical and clinical trial stage.
Evaluation of Goethite as a Catalyst for the Thermal Stage of the Westinghouse Process for Hydrogen Production
Authors: Fernández-Marchante Carmen M. , Raschitor Alexandra , Mena Ismael F. , Rodrigo Manuel A. , Lobato Justo
Published: September 2021

This work focuses on the evaluation of goethite as a catalyst for the transformation of sulfuric acid into sulfur dioxide, a reaction with great interest for the hybrid electrochemical-thermoelectrochemical Westinghouse cycle for hydrogen production. A comparison of the performance of goethite with that of CuO, Fe2O3, and SiC has been carried out. Moreover, a mixture of those catalysts was evaluated. The results demonstrate that goethite can be used as a catalyst for the thermal decomposition of sulfuric acid in the Westinghouse cycle, with an activity higher than that of SiC but lower than that of Fe2O3 and CuO. However, it does not undergo sintering during its use, but just produces small particles in its surface, which remain after the treatment. Mixtures of Fe2O3 with SiC or goethite do not produce synergism, thus operating each catalyst in an independent way.
Practical Approaches towards NOx Emission Mitigation from Fluid Catalytic Cracking (FCC) Units
Authors: Vjunov Aleksei , Kharas Karl C. , Komvokis Vasileios , Dundee Amy , Yilmaz Bilge
Published: September 2021

There appears to be consensus among the general public that curtailing harmful emissions resulting from industrial, petrochemical and transportation sectors is a common good. However, there is also a need for balancing operating expenditures for applying the required technical solutions and implementing advanced emission mitigation technologies to meet desired sustainability goals. The emission of NOx from Fluid Catalytic Cracking (FCC) units in refineries for petroleum processing is a major concern, especially for those units located in densely populated urban settings. In this work we strive to review options towards cost-efficient and pragmatic emissions mitigation using optimal amounts of precious metal while evaluating the potential benefits of typical promoter dopant packages. We demonstrate that at present catalyst development level the refinery is no longer forced to make a promoter selection based on preconceived notions regarding precious metal activity but can rather make decisions based on the best “total cost” financial impact to the operation without measurable loss of the CO/NOx emission selectivity.
Identification of the Novel Tumor Suppressor Role of FOCAD/miR-491-5p to Inhibit Cancer Stemness, Drug Resistance and Metastasis via Regulating RABIF/MMP Signaling in Triple Negative Breast Cancer
Authors: Huang Wei-Chieh , Chi Hsiang-Cheng , Tung Shiao-Lin , Chen Po-Ming , Shih Ya-Chi , Huang Yi-Ching , Chu Pei-Yi
Published: September 2021

Triple negative breast cancer (TNBC) possesses poor prognosis mainly due to development of chemoresistance and lack of effective endocrine or targeted therapies. MiR-491-5p has been found to play a tumor suppressor role in many cancers including breast cancer. However, the precise role of miR-491-5p in TNBC has never been elucidated. In this study, we reported the novel tumor suppressor function of FOCAD/miR-491-5p in TNBC. High expression of miR-491-5p was found to be associated with better overall survival in breast cancer patients. We found that miR-491-5p could be an intronic microRNA processed form FOCAD gene. We are the first to demonstrate that both miR-491-5p and FOCAD function as tumor suppressors to inhibit cancer stemness, epithelial-mesenchymal transition, drug resistance, cell migration/invasion, and pulmonary metastasis etc. in TNBC. MiR-491-5p was first reported to directly target Rab interacting factor (RABIF) to downregulate RABIF-mediated TNBC cancer stemness, drug resistance, cell invasion, and pulmonary metastasis via matrix metalloproteinase (MMP) signaling. High expression of RABIF was found to be correlated with poor clinical outcomes of breast cancer and TNBC patients. Our data indicated that miR-491-5p and RABIF are potential prognostic biomarkers and targeting the novel FOCAD/miR-491-5p/RABIF/MMP signaling pathway could serve as a promising strategy in TNBC treatment.
Evolution of Diploid Progenitor Lung Cell Applications: From Optimized Biotechnological Substrates to Potential Active Pharmaceutical Ingredients in Respiratory Tract Regenerative Medicine
Authors: Laurent Alexis , Abdel-Sayed Philippe , Hirt-Burri Nathalie , Scaletta Corinne , Michetti Murielle , de Buys Roessingh Anthony , Raffoul Wassim , Applegate Lee Ann
Published: September 2021

The objective of this review is to describe the evolution of lung tissue-derived diploid progenitor cell applications, ranging from historical biotechnological substrate functions for vaccine production and testing to current investigations around potential therapeutic use in respiratory tract regenerative medicine. Such cell types (e.g., MRC-5 or WI-38 sources) were extensively studied since the 1960s and have been continuously used over five decades as safe and sustainable industrial vaccine substrates. Recent research and development efforts around diploid progenitor lung cells (e.g., FE002-Lu or Walvax-2 sources) consist in qualification for potential use as optimal and renewed vaccine production substrates and, alternatively, for potential therapeutic applications in respiratory tract regenerative medicine. Potentially effective, safe, and sustainable cell therapy approaches for the management of inflammatory lung diseases or affections and related symptoms (e.g., COVID-19 patients and burn patient severe inhalation syndrome) using local homologous allogeneic cell-based or cell-derived product administrations are considered. Overall, lung tissue-derived progenitor cells isolated and produced under good manufacturing practices (GMP) may be used with high versatility. They can either act as key industrial platforms optimally conforming to specific pharmacopoeial requirements or as active pharmaceutical ingredients (API) for potentially effective promotion of lung tissue repair or regeneration.
Acquired Glucocorticoid Resistance Due to Homologous Glucocorticoid Receptor Downregulation: A Modern Look at an Age-Old Problem
Authors: Spies Lee-Maine L. , Verhoog Nicolette J. D. , Louw Ann
Published: September 2021

For over 70 years, the unique anti-inflammatory properties of glucocorticoids (GCs), which mediate their effects via the ligand-activated transcription factor, the glucocorticoid receptor alpha (GRα), have allowed for the use of these steroid hormones in the treatment of various autoimmune and inflammatory-linked diseases. However, aside from the onset of severe side-effects, chronic GC therapy often leads to the ligand-mediated downregulation of the GRα which, in turn, leads to a decrease in GC sensitivity, and effectively, the development of acquired GC resistance. Although the ligand-mediated downregulation of GRα is well documented, the precise factors which influence this process are not well understood and, thus, the development of an acquired GC resistance presents an ever-increasing challenge to the pharmaceutical industry. Recently, however, studies have correlated the dimerization status of the GRα with its ligand-mediated downregulation. Therefore, the current review will be discussing the major role-players in the homologous downregulation of the GRα pool, with a specific focus on previously reported GC-mediated reductions in GRα mRNA and protein levels, the molecular mechanisms through which the GRα functional pool is maintained and the possible impact of receptor conformation on GC-mediated GRα downregulation.
Increased Phosphatase of Regenerating Liver-1 by Placental Stem Cells Promotes Hepatic Regeneration in a Bile-Duct-Ligated Rat Model
Authors: Choi Jong Ho , Park Sohae , Kim Gi Dae , Kim Jae Yeon , Jun Ji Hye , Bae Si Hyun , Baik Soon Koo , Hwang Seong-Gyu , Kim Gi Jin
Published: September 2021

Phosphatase of regenerating liver-1 (PRL-1) controls various cellular processes and liver regeneration. However, the roles of PRL-1 in liver regeneration induced by chorionic-plate-derived mesenchymal stem cells (CP-MSCs) transplantation remain unknown. Here, we found that increased PRL-1 expression by CP-MSC transplantation enhanced liver regeneration in a bile duct ligation (BDL) rat model by promoting the migration and proliferation of hepatocytes. Engrafted CP-MSCs promoted liver function via enhanced hepatocyte proliferation through increased PRL-1 expression in vivo and in vitro. Moreover, higher increased expression of PRL-1 regulated CP-MSC migration into BDL-injured rat liver through enhancement of migration-related signals by increasing Rho family proteins. The dual effects of PRL-1 on proliferation of hepatocytes and migration of CP-MSCs were substantially reduced when PRL-1 was silenced with siRNA-PRL-1 treatment. These findings suggest that PRL-1 may serve as a multifunctional enhancer for therapeutic applications of CP-MSC transplantation.
Towards Understanding the Direct and Indirect Actions of Growth Hormone in Controlling Hepatocyte Carbohydrate and Lipid Metabolism
Authors: Vázquez-Borrego Mari C. , del Rio-Moreno Mercedes , Kineman Rhonda D.
Published: September 2021

Growth hormone (GH) is critical for achieving normal structural growth. In addition, GH plays an important role in regulating metabolic function. GH acts through its GH receptor (GHR) to modulate the production and function of insulin-like growth factor 1 (IGF1) and insulin. GH, IGF1, and insulin act on multiple tissues to coordinate metabolic control in a context-specific manner. This review will specifically focus on our current understanding of the direct and indirect actions of GH to control liver (hepatocyte) carbohydrate and lipid metabolism in the context of normal fasting (sleep) and feeding (wake) cycles and in response to prolonged nutrient deprivation and excess. Caveats and challenges related to the model systems used and areas that require further investigation towards a clearer understanding of the role GH plays in metabolic health and disease are discussed.
Comprehensive Characterization of 76 Pharmaceuticals and Metabolites in Wastewater by LC-MS/MS
Authors: Gómez-Canela Cristian , Edo Sílvia , Rodríguez Natalia , Gotor Gemma , Lacorte Sílvia
Published: September 2021

Wastewaters are considered one of the main sources of pollution in the aquatic environment as release a large number of contaminants every day. Emerging contaminants such as pharmaceuticals have special interest due to the high levels of consumption by the global population, their bioactive properties and because actual directives do not include the monitoring of pharmaceuticals. Moreover, it is well-known that pharmaceuticals can be degraded to metabolites or transformation products (TPs), which could be more toxic than the parental compound. In this study, we have developed an analytical method based on solid-phase extraction (SPE) and liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) to determine 76 highly consumed pharmaceuticals, including metabolites and TPs in wastewater effluents. In the 10 wastewaters analysed, the mean concentrations were in the µg L−1 levels, being mycophenolic acid, levodopa, ibuprofen, 4-aminoantypirine, losartan, amylmetacresol, amoxicillin, fluticasone, tramadol, budesonide, chlorpheniramine and diclofenac the pharmaceuticals with the highest concentrations. This study provides a comprehensive optimization on the MS conditions to determine pharmaceutical compounds and their metabolites and provides a spectral characterization to be used for the identification of these compounds in water.
Asymmetric Dimethylarginine (ADMA) in Pediatric Renal Diseases: From Pathophysiological Phenomenon to Clinical Biomarker and Beyond
Authors: Hsu Chien-Ning , Tain You-Lin
Published: September 2021

Asymmetric dimethylarginine (ADMA), an endogenous nitric oxide (NO) synthase inhibitor, inhibits NO synthesis and contributes to the pathogenesis of many human diseases. In adults, ADMA has been identified as a biomarker for chronic kidney disease (CKD) progression and cardiovascular risk. However, little attention is given to translating the adult experience into the pediatric clinical setting. In the current review, we summarize circulating and urinary ADMA reported thus far in clinical studies relating to kidney disease in children and adolescents, as well as systematize the knowledge on pathophysiological role of ADMA in the kidneys. The aim of this review is also to show the various analytical methods for measuring ADMA and the issues tht need to be addressed before transforming to clinical practice in pediatric medicine. The last task is to suggest that ADMA may not only be suitable as a diagnostic or prognostic biomarker, but also a promising therapeutic strategy to treat pediatric kidney disease in the future.
Participatory Design of an Electronic Cross-Facility Health Record (ECHR) System for Pediatric Palliative Care: A Think-Aloud Study
Authors: Busse Theresa Sophie , Jux Chantal , Kernebeck Sven , Dreier Larissa Alice , Meyer Dorothee , Zenz Daniel , Zernikow Boris , Ehlers Jan Peter
Published: September 2021

Background: Pediatric palliative care (PPC) patients experience years of multisectoral and professional care. An electronic cross-facility health record (ECHR) system can support the immediate exchange of information among PPC professionals. Based on a needs assessment, a prototype ECHR system was developed. Methods: To evaluate potential users’ perspective regarding the system, a qualitative observational study was conducted consisting of a concurrent think-aloud session and a semi-structured qualitative interview. Results: Twenty PPC professionals (nurses, physicians) from specialized outpatient PPC teams, a PPC unit, and medical offices rated the ECHR system as a helpful tool to improve the exchange and collection of information, communication between PPC professionals, and treatment planning. From the user’s point of view, the basic logic of the ECHR system should be further adapted to improve the interaction of data remirrored from patient records of outpatient and inpatient care with those entered via the system. The users wished for further functions (text search) and content (information on therapies). Some content, such as the treatment process, needs to be further adapted. Conclusion: The developed ECHR system needs to be more specific in some features by offering all available information; while for other features, be less specific to offer a quick overview. The ability to share information promptly and automatically was seen as a tremendous improvement to the quality of care for PPC patients.
Numerical Analysis of the Interactions between Plasma Jet and Powder Particles in PS-PVD Conditions
Authors: Zhang Tao , Mariaux Gilles , Vardelle Armelle , Li Chang-Jiu
Published: September 2021

Plasma spray-physical vapor deposition (PS-PVD) refers to a very low-pressure (~100 Pa) deposition process in which a powder is injected in a high-enthalpy plasma jet, and mostly vaporized and recondensed onto a substrate to form a coating with a specific microstructure (e.g., columnar). A key issue is the selection of the powder particle size that could be evaporated under specific spray conditions. Powder evaporation takes place, first, in the plasma torch between the injection location and nozzle exit and, then, in the deposition chamber from the nozzle exit to the substrate location. This work aims to calculate the size of the particles that can be evaporated in both stages of the process. It deals with an yttria-stabilized zirconia powder and two commercial plasma torches operated at different arc powers with gas mixtures of argon and helium or argon and hydrogen. First, it used computational fluid dynamics simulations to calculate the velocity and temperature fields of the plasma jets under very low-pressure plasma conditions. Then, it estimated the evaporation of the particles injected in both plasma jets assuming an isothermal evaporation process coupled with momentum and heat transfer plasma-particle models in a rarefied plasma. The calculations showed that, for different powers of the Ar–H2 and the Ar–He operating conditions of this study, the heat flux from the plasma jet to particles inside the torch is much higher than that transferred in the deposition chamber while the specific enthalpy transferred to particles is comparable. The argon-helium mixture is more efficient than the argon-hydrogen mixture to evaporate the particles. Particles less than 2 μm in diameter could be fully evaporated in the Ar–He plasma jet while they should be less than 1 µm in diameter in the Ar–H2 plasma jet.
Effect of Carbon Target Current on Ultralow Frictional Behavior of CrCN Coatings under Glycerol Lubrication
Authors: Liu Naiyu , Gao Jianguo , Xu Luyao , Wan Yong , Li Ruichuan
Published: September 2021

The aim of this paper is to find an effective way to reduce the friction and wear of steel. CrCN coating was deposited on AISI 304 stainless steel by magnetron sputtering technology, and the friction and wear properties of the coating under glycerol lubrication were studied. The hardness of CrCN coatings on stainless steel surface can reach to 17.87 GPa when the carbon target deposition current is 2A. The CrCN coating presents low friction coefficient (COF) under the lubrication of glycerol, a highly efficient green lubricant. When the load is 0.5 N, the lowest friction coefficient is only 0.01. XPS analysis on the wear track suggested that glycerol decomposed during sliding and a fluid lubricating layer was formed, which provides ultralow friction. The paper shows that the glycerol could be used as an efficient lubricant for the CrCN coating.
Identifying Potential Machine Learning Algorithms for the Simulation of Binding Affinities to Molecularly Imprinted Polymers
Authors: Lowdon Joseph W. , Ishikura Hikaru , Kvernenes Malene K. , Caldara Manlio , Cleij Thomas J. , van Grinsven Bart , Eersels Kasper , Diliën Hanne
Published: September 2021

Molecularly imprinted polymers (MIPs) are synthetic receptors engineered towards the selective binding of a target molecule; however, the manner in which MIPs interact with other molecules is of great importance. Being able to rapidly analyze the binding of potential molecular interferences and determine the selectivity of a MIP can be a long tedious task, being time- and resource-intensive. Identifying computational models capable of reliably predicting and reporting the binding of molecular species is therefore of immense value in both a research and commercial setting. This research therefore sets focus on comparing the use of machine learning algorithms (multitask regressor, graph convolution, weave model, DAG model, and inception) to predict the binding of various molecular species to a MIP designed towards 2-methoxphenidine. To this end, each algorithm was “trained” with an experimental dataset, teaching the algorithms the structures and binding affinities of various molecular species at varying concentrations. A validation experiment was then conducted for each algorithm, comparing experimental values to predicted values and facilitating the assessment of each approach by a direct comparison of the metrics. The research culminates in the construction of binding isotherms for each species, directly comparing experimental vs. predicted values and identifying the approach that best emulates the real-world data.
Effect of Interdendritic Precipitations on the Mechanical Properties of GBF or EMS Processed Al-Zn-Mg-Cu Alloys
Authors: Park Sangeun , Kayani Saif Haider , Kim Hyungrae , Jung Im Doo , Reddy N.S. , Euh Kwangjun , Seol Jae Bok , Kim Jung Gi , Sung Hyokyung
Published: September 2021

The effects of nanoprecipitations on the mechanical properties of Al-Zn-Mg-Cu alloys after GBF (gas bubbling filtration) and EMS (electromagnetic stirring) casting were investigated. Dendritic cell structures were formed after GBF processing, while globular dendritic structures were nucleated after EMS processing. Equiaxed cell sizes were smaller in the EMS-processed specimens compared to the GBF-processed specimens, confirmed by EBSD (electron backscatter diffraction) analysis. Nanoprecipitations of η′ phases inside of dendrites were observed by TEM (transmission electron microscope), and other Fe-bearing compounds were located in the dendritic boundaries. The yield strength of the T4 and T6 heat-treated specimens was close to 400 MPa and 500 MPa, respectively. Fractographic analysis was performed to investigate the effect of precipitations on tensile fracture.
Study on Phase Transformation Orientation Relationship of HCP-FCC during Rolling of High Purity Titanium
Authors: Bai Fengmei , Zhu Qingliang , Shen Jiaming , Lu Zhihan , Zhang Liqiang , Ali Naqash , Zhou Hongwei , Liu Xianghua
Published: September 2021

High purity titanium (Ti) thin strip was prepared by rolling with large deformation and was characterized by the means of Transmission Electron Microscopy (TEM), selected area diffraction (SAED) pattern, high-resolution (HRTEM) analysis, as well as Transmission Kikuchi Diffraction (TKD). It is found that there are face-centered cubic (FCC) Ti laths formed within the matrix of hexagonal close packing (HCP) Ti. This shows that the HCP-FCC phase transition occurred during the rolling, and a specific orientation relationship (OR) between HCP phase and FCC phase obeys ⟨0001⟩α// ⟨001⟩FCC and {100}α//{110}FCC. The ORs of HCP-FCC phase transition are deeply studied by TKD pole figure and phase transformation matrix. It is found that the derived results via pole figure and transformation matrix are equivalent, and are consistent with TEM-SAED analysis results, which proves that these two methods can effectively characterize the ORs of HCP-FCC phase transition and predict possible FCC phase variants.
Ionic Liquids as Protein Crystallization Additives
Authors: Tarver Crissy L. , Yuan Qunying , Pusey Marc L.
Published: September 2021

Among its attributes, the mythical philosopher’s stone is supposedly capable of turning base metals to gold or silver. In an analogous fashion, we are finding that protein crystallization optimization using ionic liquids (ILs) often results in the conversion of base protein precipitate to crystals. Recombinant inorganic pyrophosphatases (8 of the 11 proteins) from pathogenic bacteria as well as several other proteins were tested for optimization by 23 ILs, plus a dH2O control, at IL concentrations of 0.1, 0.2, and 0.4 M. The ILs were used as additives, and all proteins were crystallized in the presence of at least one IL. For 9 of the 11 proteins, precipitation conditions were converted to crystals with at least one IL. The ILs could be ranked in order of effectiveness, and it was found that ~83% of the precipitation-derived crystallization conditions could be obtained with a suite of just eight ILs, with the top two ILs accounting for ~50% of the hits. Structural trends were found in the effectiveness of the ILs, with shorter-alkyl-chain ILs being more effective. The two top ILs, accounting for ~50% of the unique crystallization results, were choline dihydrogen phosphate and 1-butyl-3-methylimidazolium tetrafluoroborate. Curiously, however, a butyl group was present on the cation of four of the top eight ILs.
Correction: Brad et al. The Chemoautotrophically Based Movile Cave Groundwater Ecosystem, a Hotspot of Subterranean Biodiversity. Diversity 2021, 13, 128
Authors: Brad Traian , Iepure Sanda , Sarbu Serban M.
Published: September 2021

The authors wish to make the following corrections to this paper [...]
Validation of Coronary Angiography-Derived Vessel Fractional Flow Reserve in Heart Transplant Patients with Suspected Graft Vasculopathy
Authors: Mileva Niya , Nagumo Sakura , Gallinoro Emanuele , Sonck Jeroen , Verstreken Sofie , Dierkcx Riet , Heggermont Ward , Bartunek Jozef , Goethals Marc , Heyse Alex , Barbato Emanuele , De Bruyne Bernard , Collet Carlos , Vanderheyden Marc
Published: September 2021

Cardiac transplant-related vasculopathy remains a leading cause of morbidity and mortality in heart transplant (HTx) recipients. Recently, coronary angiography-derived vessel fractional flow reserve (vFFR) has emerged as a new diagnostic computational tool to functionally evaluate the severity of coronary artery disease. Although vFFR estimates have been shown to perform well against invasive FFR in atherosclerotic coronary artery disease, data on the use of vFFR in heart transplant recipients suffering from cardiac transplant-related arteriopathy are lacking. The aim of the presented study was to validate coronary angiography-derived vessel fractional flow reserve to calculate fractional flow reserve in HTx patients with and without cardiac transplant-related vasculopathy. A prospective, single center study of HTx patients referred for annual check-up, undergoing surveillance coronarography was conducted. Invasive FFR was measured using a motorized device at the speed of 1.0 mm/s in all three major coronary arteries. Angiography-derived pullback FFR was derived from the angiogram and compared with invasive FFR pullback curve. Overall, 18,059 FFR values were extracted from the FFR pullback curves from 23 HTx patients. The mean age was 59.3 ± 9.7 years, the mean time after transplantation was 5.24 years [IQR 1.20, 11.25]. A total of 39 vessels from 23 patients (24 LAD, 11 LCX, 4 RCA) were analyzed. Mean distal vFFR was 0.87 ± 0.14 whereas invasive distal FFR was 0.88 ± 0.17. An excellent correlation was found between invasive distal FFR and vFFR (r = 0.92; p < 0.001). The correlation of the pullback tracing was high, with a correlation coefficient between vFFR and invasive FFR pullback values of 0.72 (95% CI 0.71 to 0.73, p < 0.001). The mean difference between vFFR and invasive FFR pullback values was −0.01 with 0.06 of SD (limits of agreements −0.12 to 0.13). In HTx patients, coronary angiography-derived FFR correlates excellently with invasively measured wire-derived FFR. Therefore, angiography derived FFR could be used as a novel diagnostic tool to quantify the functional severity of graft vasculopathy.
OCT-Angiography Findings in Patients with Amblyopia: Comparison between Healthy Controls, Treatment-Responsive, and Treatment-Unresponsive Amblyopic Patients
Authors: Salerni Annabella , Gambini Gloria , Fedeli Chiara , Paris Ludovica , Crincoli Emanuele , Savino Gustavo , Savastano Maria Cristina , Bacherini Daniela , De Vico Umberto , Rizzo Clara , Killian Raphael , Rizzo Stanislao
Published: September 2021

There is no consensus on whether amblyopia affects the retinal vascular plexus and morphology. Previous studies focused on the differences between amblyopic patients and normal controls without evaluating amblyopic eyes after patching. To evaluate differences in the superficial vascular density of amblyopic eyes, normal eyes, and amblyopic eyes reaching normal BCVA after patch therapy, OCTA was used. All patients underwent a comprehensive ophthalmological examination, including visual acuity, refraction, ocular motility tests, and anterior and posterior segment examination. OCTA was performed by an expert physician using the Zeiss Cirrus 5000-HD-OCT Angioplex (Carl Zeiss, Meditec, Inc., Dublin, OH, USA). OCTA scans were performed using a 3 × 3 mm2 and 6 × 6 mm2 fovea-centered image setting. The mean outer macular vessel density in the previously amblyopic group was 19.15 ± 0.51%. This was statistically significantly higher than in both the amblyopic group (18.70 ± 1.14%) and the normal controls (18.18 ± 1.40%) (p = 0.014). The previously amblyopic group also significantly differed from both normal controls and amblyopic eyes with regards to the inner (p = 0.011), outer (p = 0.006), and full (p = 0.003) macular perfusion. Finally, linear regression analysis revealed that BCVA was linearly correlated to outer perfusion in amblyopic (p = 0.003) and ex amblyopic eyes (p < 0.001). Considering the cross-sectional nature of our study, from our results, we can only hypothesize a possible correlation between light stimulation and retinal vasculature development. However, further longitudinal studies are needed to support this hypothesis.
Clinical Value of Bronchoscopy in Acute Respiratory Failure
Authors: Scala Raffaele , Guidelli Luca
Published: September 2021

Bronchoscopy may be considered the “added value” in the diagnostic and therapeutic pathway of different clinical scenarios occurring in acute respiratory critically ill patients. Rigid bronchoscopy is mainly employed in emergent clinical situations due to central airways obstruction, haemoptysis, and inhaled foreign body. Flexible bronchoscopy (FBO) has larger fields of acute applications. In intensive care settings, FBO is useful to facilitate intubation in difficult airways, guide percutaneous dilatational tracheostomy, and mucous plugs causing lobar/lung atelectasis. FBO plays a central diagnostic role in acute respiratory failure caused by intra-thoracic tumors, interstitial lung diseases, and suspected severe pneumonia. “Bronchoscopic” sampling has to be considered when “non-invasive” techniques are not diagnostic in suspected ventilator-associated pneumonia and in non-ventilated immunosuppressed patients. The combined use of either noninvasive ventilation (NIV) or High-flow nasal cannula (HFNC) with bronchoscopy is useful in different scenarios; the largest body of proven successful evidence has been found for NIV-supported diagnostic FBO in non-ventilated high risk patients to prevent and avoid intubation. The expected diagnostic/therapeutic goals of acute bronchoscopy should be balanced against the potential severe risks (i.e., cardio-pulmonary complications, bleeding, and pneumothorax). Expertise of the team is fundamental to achieve the best rate of success with the lowest rate of complications of diagnostic and therapeutic bronchoscopic procedures in acute clinical circumstances.
On the Optimal Selection and Integration of Batteries in DC Grids through a Mixed-Integer Quadratic Convex Formulation
Authors: Serra Federico Martin , Montoya Oscar Danilo , Alvarado-Barrios Lázaro , Álvarez-Arroyo Cesar , Chamorro Harold R.
Published: September 2021

This paper deals with the problem of the optimal selection and location of batteries in DC distribution grids by proposing a new mixed-integer convex model. The exact mixed-integer nonlinear model is transformed into a mixed-integer quadratic convex model (MIQC) by approximating the product among voltages in the power balance equations as a hyperplane. The most important characteristic of our proposal is that the MIQC formulations ensure the global optimum reaching via branch & bound methods and quadratic programming since each combination of the binary variables generates a node with a convex optimization subproblem. The formulation of the objective function is associated with the minimization of the energy losses for a daily operation scenario considering high renewable energy penetration. Numerical simulations show the effectiveness of the proposed MIQC model to reach the global optimum of the optimization model when compared with the exact optimization model in a 21-node test feeder. All the validations are carried out in the GAMS optimization software.
Energy-Efficient Clustering Scheme for Flying Ad-Hoc Networks Using an Optimized LEACH Protocol
Authors: Bharany Salil , Sharma Sandeep , Badotra Sumit , Khalaf Osamah Ibrahim , Alotaibi Youseef , Alghamdi Saleh , Alassery Fawaz
Published: September 2021

A Flying Ad-hoc network constitutes many sensor nodes with limited processing speed and storage capacity as they institute a minor battery-driven device with a limited quantity of energy. One of the primary roles of the sensor node is to store and transmit the collected information to the base station (BS). Thus, the life span of the network is the main criterion for the efficient design of the FANETS Network, as sensor nodes always have limited resources. In this paper, we present a methodology of an energy-efficient clustering algorithm for collecting and transmitting data based on the Optimized Low-Energy Adaptive Clustering Hierarchy (LEACH) protocol. The selection of CH is grounded on the new optimized threshold function. In contrast, LEACH is a hierarchical routing protocol that randomly selects cluster head nodes in a loop and results in an increased cluster headcount, but also causes more rapid power consumption. Thus, we have to circumvent these limitations by improving the LEACH Protocol. Our proposed algorithm diminishes the energy usage for data transmission in the routing protocol, and the network’s lifetime is enhanced as it also maximizes the residual energy of nodes. The experimental results performed on MATLAB yield better performance than the existing LEACH and Centralized Low-Energy Adaptive Clustering Hierarchy Protocol in terms of energy efficiency per unit node and the packet delivery ratio with less energy utilization. In addition, the First Node Death (FND) is also meliorated when compared to the LEACH and LEACH-C protocols.
Forecasting Natural Gas Production and Consumption in United States-Evidence from SARIMA and SARIMAX Models
Authors: Manigandan Palanisamy , Alam MD Shabbir , Alharthi Majed , Khan Uzma , Alagirisamy Kuppusamy , Pachiyappan Duraisamy , Rehman Abdul
Published: September 2021

Research on forecasting the seasonality and growth trend of natural gas (NG) production and consumption will help organize an analysis base for NG inspection and development, social issues, and allow industrials elements to operate effectively and reduce economic issues. In this situation, we handle a comparison structure on the application of different models in monthly NG production and consumption forecasting using the cross-correlation function and then analyze the association between exogenous variables. Moreover, the SARIMA-X model is tested for US monthly NG production and consumption prediction via the proposed method for the first time in the literature review in this study. The performance of that model has been compared with SARIMA (p, d, q) * (P, D, Q)s. The results from RMSE and MAPE indicate that the superiority of the best model. By applying this method, the US monthly NG production and consumption is forecast until 2025. The success of the proposed method allows the use of seasonality patterns. If this seasonal approach continues, the United States’ NG production (16%) and consumption (24%) are expected to increase by 2025. The results of this study provide effective information for decision-makers on NG production and consumption to be credible and to determine energy planning and future sustainable energy policies.
Application Study in the Field of Solutions for the Monitoring Distribution Transformers of the Overhead Power Grid
Authors: Chaves Tiago Rabelo , Martins Marcos Aurélio Izumida , Martins Kennedy Alves , de Macedo Amadeu Fernandes , de Francisci Silvia
Published: September 2021

This paper will present the development and application of overhead transformers of the distribution grid, as well as the different technologies used for the gathering of electrical quantities, in the field of a monitoring solution. The solution reports the values of the quantities and alarms of operation remotely and almost in real-time. The development of this solution seeks to provide an electrical grid with greater reliability, proposing the reduction of KPIs (Key Performance Indicator), such as SAIDI (System Average Interruption Duration Index) and SAIFI (System Average Interruption Frequency Index), through more transparent monitoring of the behavior of the electrical distribution grid and its equipment. Through the research and development (R&D) project Urban Futurability, ENEL (Ente nazionale per l’energia elettrica) Distribution São Paulo seeks to apply the solution by implementing the concept of smart grids, an idea that has been growing each year by virtue of technological developments and the employment of new sensors in electrical distribution grids. Urban Futurability seeks to innovate the automation area, digital twin, and construction enhancement in the Vila Olímpia neighborhood of São Paulo, Brazil.
Efficiency Increase of Energy Systems in Oil and Gas Industry by Evaluation of Electric Drive Lifecycle
Authors: Korolev Nikolay , Kozyaruk Anatoly , Morenov Valentin
Published: September 2021

The efficiency issue of energy systems in the oil and gas industry is a crucial factor nowadays. Energy share in the production costs of oil and gas can reach 50%. Among the most important energy equipment are the electric drives of the pumps, compressors, auxiliary units, etc. The paper considered the lifecycle of the electric drives used at oil and gas fields and evaluated their efficiency parameters during periods of operational wear or malfunctioning. At the same time, the lifecycle of the energy equipment was seen as its technical state during operation. Based on the spectral analysis of the current using the finite Fourier transform (FFT), the main frequency components were identified that characterize the type and level of malfunction, taking into account defined efficiency indicators of the electric drive. A technique for assessing the technical state of an electric drive was proposed based on the normalized levels of the amplitudes of the frequency components. Predictive management of the electric drive was implemented in terms of correcting the control system when a malfunction occurs, providing the required efficiency indicators. Boundaries for the technical state of the electric drive were determined. Recommendations for further operation, terms of maintenance and repair or preventive management were presented.
Statistical Analysis of Lightning Flashes over Wind Parks in Greece
Authors: Androvitsaneas Vasilios P. , Damianaki Katerina D. , Nicolopoulou Eleni P. , Gonos Ioannis F.
Published: September 2021

Currently, lightning phenomenon, mechanisms, and impacts on lives and infrastructures have been satisfactorily decoded and studied. Sound knowledge of lightning parameters is available in international literature. Yet, there are few studies referring to lightning statistics such as the number of flashes over an area, current amplitude distribution, etc., except for official documentation from national weather services, perhaps because of the stochastic nature of lightning. This work presents full recorded data for lightning flashes over wind farms distributed at the Hellenic territory. The data come from real time measurements at wind farm stations from 2011 to 2020 and concern number of CG flashes and lightning current amplitude. They are statistically processed and analyzed and contain useful information regarding the lightning characteristics of various geographic regions all over the country. Furthermore, the study displays data from field measurements of ground resistance at wind turbines and highlights techniques of designing and enhancing grounding systems of wind turbines for given lightning protection level (LPL). The present study, therefore, provides stakeholders with useful data and noteworthy conclusions about lightning occurrence and characteristics in Greece in order to make informed decisions on the various project stages, such as selection of the wind farm site, proper and in-depth risk assessment, and investment in safety measures for personnel and equipment.