bluuebunny/crossref_metadata_2025 huggingface dataset:
BURNOUT AND PERFECTIONISM IN STUDENTS: CROSS-CULTURAL CHARACTERISTICS
Authors:   Peoples’ Friendship University of Russia (RUDN University), Mikhailova O.B. , Farennikova E.S. ,   Peoples’ Friendship University of Russia (RUDN University)
Published: January 2023

Perfectionism as a psychological phenomenon presents significant prospects for studying for modern researchers. Of particular interest are studies of possible correlations between perfectionism and emotional burnout among representatives of various professional groups and students. The novelty of this work lies in the fact that the differences and relationships between the manifestations of emotional burnout, self-assessment of mental states and perfectionism among Chinese and Russian students are considered. The study involved 40 Russian and 40 Chinese undergraduate and graduate students. The following methods were used: 1) Multidimensional scale of perfectionism by P. Hewitt and G. Flett adapted by I. I. Gracheva; 2) The burnout questionnaire by K. Maslach, adapted by N.E. Vodopyanova; 3) Methodology for diagnosing self-assessment of mental states by G. Eysenck. All methods for Chinese respondents were translated into Chinese. As a result of applying comparative and correlation types of analysis, cross-cultural differences and relationships between indicators of perfectionism, self-assessment of the emotional state and characteristics of emotional burnout were revealed. Chinese students showed low results on the aggressiveness scale compared to Russian students. However, Russian students scored higher on the anxiety scale than Chinese students. Chinese students, in comparison with Russian respondents, show a greater degree of confidence in themselves and in their future. In the course of the study, average indicators of rigidity were found in both groups of respondents. However, the level of rigidity in Russian students is higher than in Chinese students. In conclusion, the article presents recommendations for the correction of emotional burnout, mental states and perfectionism among students.
THE LEVEL OF INFORMATION STRESS OF UNIVERSITY STUDENTS IN A PANDEMIC
Authors:   Bunin Yelets State University, Kolosova I.G.
Published: January 2023

The sudden change in the living conditions and lifestyle of young people under the restrictions that were required during the pandemic is insufficiently studied. In particular, there are different points of view on the usefulness and necessity of distance learning technologies, to which higher education institutions were forced to switch. In the article, the author analyzes the increase in stress levels and especially information stress during a pandemic. The characteristic of the concept of information stress is given. Various points of view on the causes of stress in general, information stress in particular, its manifestations and consequences are analyzed. The results of a diagnostic study of information stress in students obtained using survey methods are presented. The author’s questionnaire and standardized methods were used: rapid diagnosis of K. Schreiner’s stress state (DSS, 1993); lifestyle analysis (Boston stress test); stress tolerance test. The level of information stress during the pandemic period and the causes are determined: information overload due to educational activities; anxiety about the future; the rapidity of the changes taking place, negative news. These data allow us to conclude that the increase in the level of information stress is not directly related to distance learning. The productive students’ coping strategies are defined: communication with friends, a loved one; sleep, rest, change of activities; analysis of their actions, search for other options; change of their behavior in this situation; physical activity. Unproductive coping strategies are noted, overeating is indicated as the main one. The main psychophysiological manifestations of stress are identified: headaches, increased fatigue; palpitations, heart pain; heavy breathing; tension or muscle trembling. The obtained results indicate the need for a more detailed study of the causes and comping strategies for overcoming information stress in students.
DYNAMICS OF PROFESSIONAL SELF-DETERMINATION OF COLLEGE STUDENTS IMPLEMENTING INCLUSIVE PRACTICE
Authors:   Moscow State University of Humanities and Economics, Solovey L.B. , Vakku G.V. ,   Moscow Polytechnic University, Meshchanin R.A. ,   Moscow State University of Humanities and Economics
Published: January 2023

The relevance of the article is due to the fact that in the modern world there is high competition among specialists in the labor market. In these conditions, proper professional self-determination of young people is important. Schoolchildren have not formed the skill of orientation among the specialties. They lack knowledge about the requirements for a particular profession, often they cannot competently assess their personal qualities and abilities, they are guided by the opinion of their parents or the prestige of their future profession. As a result, they go to study at those universities and technical schools that do not correspond to their orientation and interests. It is only during the course of training that students begin to understand that they do not have the necessary abilities that the profession they receive presents to them. However, both teachers and parents of these students insist on further education and obtaining a diploma, instead of helping them choose another specialty. An educational institution, as a rule, is not interested in students going to another educational institution, as this leads to a decrease in its financial security. Psychology, characterizing a mature personality, notes that one of the main criteria of maturity is professional competence in a particular field, not excluding changes in the trajectory of the choice of specialties throughout life. For this reason, researchers believe that professional activity is not a choice for the rest of life and may vary from the stages of personality formation. The research is devoted to the study of the dynamics of professional self-determination of college students implementing inclusive practice, as well as the study of differences in professional self-determination of conditionally healthy students and students with disabilities.
Prática Pedagógica na Formação Inicial de Professores e Educação para o Desenvolvimento Sustentável
Authors: Rodrigues Domingas da Anunciação Madalena Calovela , Andrade Ana Isabel
Published: January 2023

Este estudo apresenta os resultados de uma análise de artigos publicados em revistas de Educação, cujo objetivo é compreender os modos como são concebidas e desenvolvidas a Prática Pedagógica no contexto da Formação Inicial de Professores, numa perspetiva de Educação para o Desenvolvimento Sustentável (EDS). A metodologia utilizada foi a de revisão sistemática de 10 artigos baseados em estudos empíricos, publicados entre 2016 e 2021, disponíveis em acesso aberto em revistas acadêmicas da área. Após a seleção dos artigos, estes foram sujeitos a uma análise de conteúdo, o que possibilitou compreender que a EDS constitui uma premissa das agendas políticas de várias organizações internacionais e que a sua integração nos currículos de Formação Inicial de Professores (FIP) se baseia em abordagens multi, inter e transdisciplinares na Prática Pedagógica. Estas abordagens devem promover o desenvolvimento de competências de pensamento crítico-reflexivo, autonomia e iniciativa na resolução de problemas reais, assim como a capacidade de transformação de si próprio e dos seus pares, a fim de alcançar mudanças nos sistemas educativos de forma holística. Os resultados apontam para a promoção de ações e a integração de abordagens de EDS na FIP de modo a possibilitarem contribuir para a qualidade de vida e garantia de um futuro mais sustentável das sociedades. As conclusões remetem-nos que a melhoria na operacionalização das PP de FIP passa por integrar perspetivas que realçam o desenvolvimento de competência profissionais docentes a nível do saber, do saber fazer e do saber estar, necessárias para as transformações desejadas no processo educativo no geral, incluindo estas a EDS.
Benefits of exclusive breastfeeding during the newborn’s first months of life
Authors: Santos Ian , Curado Aline , Freire Anna , Martins Beatriz , Barros Rebeca , Wehbe Maria
Published: January 2023

To have breastfeeding only until the ideal age is still an important challenge in Brazil. There are several factors that play a role in interrupting exclusive breastfeeding, from false information to difficulties in offering breast milk. However, it is up to healthcare professionals to have full mastery of aspects related to the benefits of breast milk for the health and well-being of infants and nursing mothers for better care in their follow-up. As a result, we undertook a narrative literature review, with emphasis on the main aspects and benefits of breast milk for infant health, based on 17 papers found in the Medline and SciELO databases. We selected studies that dealt with the purpose of the review, based on assessing the respective abstracts. From the review of selected studies, we found that Exclusive Breastfeeding has benefits beyond the nutritional field and offers a lower risk of developing chronic diseases such as diabetes, hypertension, obesity; and provides protection against different types of cancer to the mother. There was also a discussion that Primary Healthcare plays a key role in ensuring that infants receive breast milk for the proper amount of time. On the other hand, there are still obstacles in the promotion of quality breastfeeding, especially for mothers and infants in situations of greater social vulnerability, an aspect that must be considered in healthcare.
Using Scaffolding Strategy in Developing Speaking Ability for EFL University Students
Authors: Abdullah Elaf Subhi
Published: January 2023

This research aims at finding whether the scaffolding strategy can improve the students’ speaking ability. The problem highlighted in this research is the students' low level of speaking in English language. The scaffolding Strategy can improve Students' motivation to control English language. There are many ways that can be used to develop the speaking skill, among these ways are games, group work and many other ways.

   Through using this strategy students can be motivated to join the lesson, so they will take effective part of the lesson. Without using this strategy students are unable to achieve their aims. The teacher has to use this strategy for the benefit of himself and his students. Students of English as foreign language may face many problems that cannot be solved without the teachers help.

      There are many advantages and disadvantages of using this strategy that can help or retard the student's ability to learn how to use this language. All things in this Strategy can be very helpful for the students to control language. Every teacher has to use this strategy in his teaching as a result he can control his class and enhance his students' speaking ability.
المكان المعادي في رواية (موت الأم) لحنون مجيد
Authors: Al- Hamad Ibrahim Mustafa , Musa Hussein Ali Mahdi
Published: January 2023

يختلف المكان بحسب وجوده داخل النص، وحسب الحدود الجغرافية والعاطفية له، كما أن المكان يحمل شحنات نفسية تقوم بدورها على إحداث التفاعل بين المكان والشخوص والأحداث، فتتوزع الأماكن بين الأليف والمعادي، وتتفرع بين ذا وذاك حسب ثنائيات (المغلق والمفتوح) و( الثابت والمتحرك)، وهي ثنائيات تتداخل في بعضها البعض ولا تتوزع .
    وأن المكان يؤدي دوراً سلطوياً  داخل العمل الروائي أيًا كان تصنيفه وفي هذه الرواية التي نحن بصدد الحديث عن المكان المعادي في رواية تعج بالشحنات الثقافية والعاطفية والنفسية التي تتبدى من خلال الأحداث المساعدة والحدث الرئيس وهو ( موت الأم).
الرواسب اللغوية في (شواذ القراءات) للكرماني (ت بعد 563هـ) - دراسة تأصيلية في ظاهرة الإبدال اللغوي–
Authors: Ahmed Khalil Rashid , Abubakir Herish Umer
Published: January 2023

يرى الباحثون أنّ اللغة العربية المألوفة لنا قد احتفظت بعناصر قديمة ترجع إلى السامية الأم أكثر مما احتفظت به الساميات الأخرى ، ويرى البحث أنّ قضية التحول الصوتي (الإبدال) في اللغة العربية، بحاجة إلى أنْ تدرس ضمن تلك المنظومة اللغوية التي تسمى اللغات السامية ؛ لأننا نجد في العربية أصوات الكلمة الواحدة تتغير ، ليحلّ صوت مكان آخر مع إبقاء الأصوات الأخرى من دون أنْ يؤدي ذلك إلى تغيّر في المعنى ، ونقف حيارى إزاء ذلك حين نحاول معرفة الكلمة الأصل ، مثل قولهم :(إياك – هياك) ، و(كشط – قشط) ، و(نعم – نأم) وغيرها .
   ومن هنا كانت هذه الدراسة محاولة متواضعة للوقوف على الواقع اللغوي للعربية قبيل الاسلام كما تمثله القراءات القرآنية الشاذة ، وذلك من خلال تلمس بعض المظاهر التاريخية لظاهرة الإبدال اللغوي - التي تعدّ من مظاهر اختلاف اللهجات- في كتاب (شواذ القراءات ) للكرماني (ت بعد 563 هـ) . وتنبع أهمية الدراسة من حيث  أنها تصلح أنْ تكون جزءاً من ملامح ما نتخيل أنه الصورة الأولى للعربية ، حيث لا نشك أنّ القراءات تمثل منهجاً في النقل لا يصل إلى وثاقته علم آخر مهما يكن حتى منهج الحديث النبوي .
دور المتلقي العباسي في تحديد موضوعات القصيدة العباسية
Authors: Ismeel Khalid Saadi
Published: January 2023

يتكئ هذا البحث على بيان الدراسات النقدية وفهم آلياتها في تصوير الشعر العباسي، فالقصيدة العباسية تحمل مكنونات الإبداع والتي بين طياتها   تتنوع الأغراض الشعرية التي لابد لها من وجود العاطفة، وهي مصدر الهام ومنبع التخيل، والتجربة الشعرية ليست عملا كيمائيًا علميًا وإنما هي صورة من صور التخيل، والإيهام بحيث يكوّن عالمًا ليس له وجود إﻻ في عالم الشاعر وعقله الباطن والمهمة ثقيلة وجسيمة أمام الشاعر، إذ استطاع من خلال ذلك أن يعبر عن مدى نجاح الشاعر في نقل تلك التجارب للآخرين وإقناعهم بها. وتناول البحث دور المتلقي العباسي في تحديد موضوعات القصيدة العباسية. ونفهم من ذلك أن العلاقة بين المتلقي والشاعر هي علاقة كبيرة في موضوع اختيار تلك الأغراض الشعرية التي اشتهرت في العصر العباسي  ، ونستطيع أن نعرف العلاقة بين المجتمع العباسي والشاعر عند استقبال المتلقي للشعر والأغراض التي يمكن الاتصال بها من حيثيات الإبداع , لأن الشاعر والمجتمع يشكلان معا وحدة ديناميكية مرتبطة ارتباطاً كبيراً بالوقائع حيث تكون حية، أو متفاعلة بكل ما لهذا التعبير من معنى.
Prospects for the Development of the Great Tumangan Initiative (GTI) in the New Geopolitical Reality
Authors: Stepanov Nikita Sergeevich
Published: January 2023

The subject of the study is the process of East Asian regionalism, considered in the context of the development of the Great Tumangan Initiative. The proposed goal is to characterize, analyze and evaluate the impact of the new geopolitical reality on the prospects for integration processes in Northeast Asia. The main research methods used in the study are a literature review on the topic and a descriptive method. As a result of the work, the following can be distinguished: analysis of geopolitical factors affecting the integration processes in Northeast Asia; the features of the development of the Great Tumangan Initiative are determined and the main problems limiting the effectiveness of this initiative are identified. The scientific novelty lies in the substantiation of the priority directions for the development of the untapped potential of the Great Tumangan Initiative: improvement of institutional support; the need to cooperate simultaneously at four levels: regional, local, multilateral and bilateral. It is concluded that the achievement of regional connectivity is the main priority in the development of regional cooperation and economic integration in Northeast Asia.
Optimization of Time, Temperature, and pH for the Extraction of Anthocyanin from Buni (Antidesma bunius) Fruit
Authors: Juhadi William , Muzi Marpaung Abdullah
Published: January 2023

The Box-Behnken design to find the optimum condition for anthocyanin extraction of Buni (Antidesma bunius) fruit powder was applied. Color intensity (CI), total monomeric anthocyanin (TMA), total phenolic content (PC), and antioxidant activity (AA) were the parameters selected to express optimality resulted from the extraction process. The three studied factors were temperature (30-90oC), time (30-90 minutes), and pH of solvent (1-3). The extraction was conducted in a water bath shaker under no light by HCl-acidified water as a solvent with a 1:25 (w/v) powder to solvent ratio. The quadratic model described the effect of factors on CI, TMA, and AA of buni fruit extract, while the linear model suitable for the total phenolic content. All factors influenced the CI and TMA, but time was insignificant for PC and antioxidant activity (p < 0.05). The optimum parameter for extraction was at 68oC for 30 minutes with pH 1 solvent. The 95% confidence interval of CI, TMA, PC, and AA were 40.29 ± 0.91, 555.17 ± 13.34 mg/l, 1084.4 66.845 ± 66.85 mg GAE/l, and 45.00 ± 2.56 % inhibition, respectively. The color and anthocyanin stability test showed that the extract was almost colorless at pH 5-6, but the anthocyanin was relatively stable with half-life 28 and 17.6 days, respectively. At pH 7-8 the stability of purple-blue color and anthocyanin of the extract was extremely low. The half-life of the color and anthocyanin was less than 2 and 10 hours, respectively.
Nuevas tecnologías en Marruecos: ¿empoderamiento femenino o brecha de género?
Authors:   Universitat d’Alacant (España), Garro Sánchez Inmaculada
Published: January 2023

The proposal in the present article is to reflect on the use of the technological tools, and in special, the social networks among Moroccan women at present. We pretend to remark these technological tools favored freedom of expression for women in big cities. However, the difference in terms of economy and society around the country produces a situation in which women have less opportunities than men in poorer zones. Therefore, in those areas the arrival of Internet has created a gender gap even more extended.
Los inicios y primeros logros de la Red UNA STEM
Authors:   Universidad Nacional (Costa Rica), Hernández Ruiz Irene , Arias Andrés María ,   Universidad Nacional (Costa Rica), Esquivel Dobles Carolina ,   Universidad Nacional (Costa Rica), Calvo Sánchez Khalia ,   Universidad Nacional (Costa Rica), Loría Valverde Francisco ,   Universidad Nacional (Costa Rica), Chaverri Ramos Christian ,   Universidad Nacional (Costa Rica)
Published: January 2023

The Red UNA STEM is a network founded by four professors from two faculties of the Universidad Nacional (UNA): Facultad de Ciencias Exactas y Naturales and Facultad de Ciencias de la Tierra y el Mar. This project aims to permeate and promote scientific knowledge and skills in children and adolescents, making an important effort in the inclusion of gender issues in many of the activities organized, in addition to generate and publicize learning opportunities in the scientific area, as well as promoting STEM careers and research projects among students and faculty members from the UNA. In this paper, we summarize the experiences of this network during the first year of its creation, in order to promote the creation of similar initiatives to reach the general public and provide spaces for children, adolescents and adults to learn about technology and science through the use of different tools as Scratch Jr., Scratch and Open Roberta as well as interact with scientific content and with the people doing scientific research.
Cuerpo político des-censurado y quiebre de la familia patriarcal en la erografía contemporánea
Authors:   Universidad de Yaundé I (Camerún), Fokou-Ngouo Arthur Freddy
Published: January 2023

This work addresses the issue of erography from a subversive perspective. It is a question of going against the ideology framed by the patriarchal family and reflected in the society that was inspired by it, the patriarchal society. Based on the radical American feminism of the late 20th century, it will be a question of highlighting the way in which the authors narrate the body-sex in order to transgress the values traditionally attributed to the phallocentric family. Thus, this study wants to consider the narration of the sex-body as a weapon of resistance to the ideology spread long-term by the patriarchal family and on which the patriarchate was based, in order to subvert the latter.
#MeReclamoMía: representaciones y narrativas en torno al cuerpo femenino de instagrammers #BodyPositive
Authors:   Pontificia Universidad Católica (Perú), Fernández Prada Alexandra Reyes , Ramírez Sánchez Luciana ,   Pontificia Universidad Católica (Perú), Chávez Pacheco Ruth ,   Pontificia Universidad Católica (Perú)
Published: January 2023

Recently, in social networks such as Instagram, it is common to find non-normative bodies challenging the hegemonic ideals that govern over the bodies. Focusing on the activism in social networks, this investigation addresses the representations and narratives about the female body of three Body Positive Fers. At the same time, this study includes three other types of participants: specialists in gender topics, body and Body Positive; fat activists and/or Body Neutrality with a critical perspective about the Body Positive movement; and followers of Body Positive accounts. Firstly, we identify the digital trajectories, profiles and content of the Instagrammers. Secondly, we analyze the representations of the female body that they show on their profiles. Thirdly, we examine the narratives about the female body that Instagrammers promote as a response to hegemonical body ideals.
Las madres jóvenes en España. Explorando los condicionantes de la edad a la primera maternidad desde la perspectiva de géner
Authors:   Universidad de Granada (España), Danet Danet Alina , Bote Marcos ,   Universidad de Murcia (España)
Published: January 2023

This article analyzes the determinants of age at first childbearing among young women in Spain. First, it provides a theoretical, conceptual and empirical review on the age as one of the determinants of first motherhood. Then, it analyses the results of the Synthetic Report of 2019 Youth Maternity Study performed by the Queen Sofia Center on Adolescence and Youth. Finally, a quantitative study is conducted with the sample of mothers, with the aim of analyzing the gender implications of variables influencing age at first childbearing. Age cohort, level of studies, employment and couple situation and availability of independent housing appear as the main determinant categories of an unwanted untimely motherhood pattern, characterized by unstable couple situations that affect the trajectory of women’s life. The results indicate the need to generate public policies for equality and social justice
Wspomaganie procesu organizacji uczenia się dziecka w okresie zdalnej edukacji w doświadczeniu rodziców zastępczych
Authors: Kaszubska-Dziergas Patrycja , Nycz Edward
Published: January 2023

Tło badań: Rodzicielstwo zastępcze jest szczególnym rodzajem rodzicielstwa, które wymaga zaangażowania, poświęcenia, cierpliwości oraz odpowiednich umiejętności. Zdalne nauczanie w okresie Covid-19 było nową sytuacją zadaniową dla uczniów i ich opiekunów. Artykuł jest pewnym zapisem podmiotowej świadomości czasu zarazy lat 2020–2022.Cel badań: Poznanie doświadczeń rodziców zastępczych w sytuacji wyznaczonych im przez system edukacyjny zachowań ułatwiających funkcjonowanie dzieci w czasie nauki zdalnej.Metoda badawcza: Artykuł prezentuje rezultaty pilotażowych badań metodą wywiadu częściowo ustrukturyzowanego, przeprowadzonych na grupie rodziców zastępczych w marcu 2022 roku.Osiągnięte wyniki: Analiza zebranego materiału empirycznego ukazała, że w swoich doświadczeniach i wyznaczonych im zachowaniach przez system edukacyjny – rodzice zastępczy wskazywali głównie na niedostatki współdziałania z nauczycielami i uogólnioną placówką szkoły we wspomaganiu procesu uczenia się dziecka w okresie zdalnej edukacji.Wnioski: Świadomość zmian u badanych rodziców zastępczych uwarunkowana czynnikami zewnętrznymi zaistniałej sytuacji wskazywała na osobistą potrzebę dopasowania się do zaistniałej sytuacji edukacyjnej w celu pomocy wychowankom poddanym ich opiece.
Attitudes of university students towards institution of a marriage
Authors: Ivkov Dzigurski Andjelija , Vučković Smiljana , Stajić Stefan , Sekulić Milena , Bibić Ljubica , Jovanov Jelena , Dragin Aleksandra
Published: January 2023

Until recently, marriage was the only socially acceptable community of two partners of different gender, with the goal of creating a family and prolonging the human race. The aim of this paper is to examine the attitudes of University students towards marriage and family. The research was based on the survey regarding the attitudes of students from the University of Novi Sad, Serbia towards institution of marriage. Collected data were analysed by using the SPSS statistical software. The main results indicate that 93.8% of respondents want to get married one day; an ideal number of children for a family to have been two (48.4%); 54.6% of respondents strongly agreed that if being in a marriage does not work properly, they should divorce. The results of these analyses and their limitations suggest guiding a future research according to different attitudes of respondents. This research provides the most ambitious and systematic analysis to date the attitudinal evidence on the attitudes of family, future children, and divorce among University students.
Interaktive Lern- und Übungsaufgaben in der Physiklehramtsausbildung
Authors: Watzka Bianca
Published: January 2023

Lernen ist ein aktiver und konstruktiver Prozess. Interaktive Aufgaben erlauben eine Aktivierung der Lernenden in jedem Lehrformat. Offen ist die Frage, ob es Unterschiede im Bearbeitungserfolg und der Änderung des Professionswissens beim Lernen mit interaktiven Aufgaben unter verschiedenen Lehrformaten gibt. Ebenso ist offen, inwieweit sich angehende Lehrkräfte vorstellen können, mit Hilfe eines Tools solche Aufgaben selbst zu erstellen und in ihrem späteren Berufsleben als Lehrmittel einzusetzen.
Ein interaktives Aufgabenset wurde mittels drei verschiedener Methoden gelehrt und evaluiert. Die Stichprobe (N=66) stellten Lehramtsstudierende der Physik. Sie bearbeiteten einen Lernpfad mit interaktiven Aufgaben, um sich fachdidaktisches Wissen zu einem Thema zu erarbeiten und zugleich ein Tool für die Entwicklung solcher Aufgaben kennen zu lernen.
Die Ergebnisse zeigten keine signifikanten Unterschiede im Bearbeitungserfolg und Professionswissen zwischen der Online- und Präsenzlehre. Jedoch zeigten die im Selbststudium Lernenden signifikant kürzere Bearbeitungszeiten, ein chaotischeres Lernverhalten, einen geringeren Bearbeitungserfolg und geringere Zuwächse im Professionswissen. Die Akzeptanz der Studierenden in Bezug auf interaktive Aufgaben und das exemplarische Tool stieg durch die Arbeit mit dem Aufgabenset in allen Gruppen an.
Genetic diversity of epidermolysis bullosa in Russian patients
Authors: Ю.Ю. Коталевская,
Published: January 2023

Буллезный эпидермолиз (БЭ) относится к группе редких генных дерматозов и отличается высокой генетической гетерогенностью. В настоящем исследовании представлены первые результаты обследования 305 российских пациентов с БЭ, у которых выявлено 217 генетических вариантов в 8 генах - KRT5, KRT14, KLHL24, COL17A1, LAMB3, COL7A1, FERMT1, TGM5. Из 217 вариантов 96 (44,2%) были впервые выявлены. Рассмотрено генетическое разнообразие выявленных вариантов при разных клинических типах БЭ.

Epidermolysis bullosa (EB) is the group of rare genodermatoses and is characterized by high genetic heterogeneity. The article presents the first results of the examination of 305 Russian patients with epidermolysis bullosa. The 217 genetic variants were identified in 8 genes - KRT5, KRT14, KLHL24, COL17A1, LAMB3, COL7A1, FERMT1, TGM5. The 96 (44.2%) variants from the 217 were identified for the first time. The genetic diversity of the identified variants in different clinical types of EB is considered.
The non-canonical effect of tyrosine kinase inhibitors for the treatment of malignant tumors on gene expression
Authors: А.Ю. Кузеванова, , А.В. Карпухин, , А.А. Алимов,
Published: January 2023

Таргетные препараты для лечения онкологических заболеваний, в частности, мультикиназные ингибиторы сунитиниб и сорафениб, широко применяются в онкологической практике, и изучение особенностей их применения весьма актуально. На модели культивируемых раковых клеток in vitro показано, что ингибиторы киназ способны усиливать экспрессию генов опухолевой прогрессии (SNAI1, SNAI2, CD44, CDH1, CLDN1), связанных с эпителиально-мезенхимальным переходом (ЭМП). Показана активация таких генов при действии низких доз тирозинкиназных ингибиторов - сунитиниба и сорафениба. Активация изученных генов была различной в разных культурах и зависела от примененного препарата. Предположено, что в силу локального неравномерного распределения лекарственных средств в тканях опухоли, ингибиторы киназ могут являться одной из причин активации экспрессии генов, ассоциированных с ЭМП, и, таким образом, способствовать ее прогрессии.

Targeted drugs for the treatment of oncological diseases, in particular, the inhibitors of Sunitinib and Sorafenib, are widely used in oncological practice and the study of the peculiarities of their application is very relevant. On the models of cultured cancer cells in vitro it was shown that kinase inhibitors are able to strengthen the expression of tumor progression genes (SNAI1, SNAI2, CD44, CDH1, CLDN1) associated with the epithelial-mesenchymal transition (EMT). The activation of such genes is shown under the action of low doses of tyrosine kinase inhibitors - Sunitinib and Sorafenib. The activation of the studied genes was different in different cultures and depended on the applied drug. It was assumed that due to the local uneven distribution of drugs in tissues of the tumor, kinase inhibitors may be one of the reasons for activating the expression of genes associated with the epithelial- mesenchymal transition, and thus contribute to its progression.
Clinical characteristics and epidemiology of lysosomal storage diseases
Authors: В. Н. Горбунова, , Н. В. Бучинская, , Е. Ю. Захарова,
Published: January 2023

Обобщены основные клинические характеристики большой группы из 30 лизосомных болезней накопления (ЛБН), включающей мукополисахаридозы (МПС), сфинголипидозы (СЛЗ) и гликопротеинозы (ГПЗ). Целью работы является выявления общих и частных закономерностей в проявлении ЛБН. При всех ЛБН наблюдается синдромальный характер поражения. Почти для половины изученных заболеваний характерен гурлер-подобный фенотип (ГПФ). Наиболее частыми клиническими проявлениями ЛБН являются неврологические аномалии, офтальмопатии, нарушения слуха, гепато- и спленомегалия, грыжи, скелетные дисплазии, тугоподвижность и контрактуры суставов. Погибают больные чаще всего от сердечно-сосудистой недостаточности и рецидивирующих инфекций. Гематологические, кожные и нефрологические проявления наблюдаются только при некоторых ЛБН. Для многих ЛБН (63%) типичен клинический полиморфизм как по дебюту, так и по существованию аллельных серий заболеваний. Почти в трети случаев (27%) отмечается генетическая гетерогенность, то есть сходный характер течения заболеваний, обусловленных мутациями в разных генах. ЛБН - это редкие заболевания, частоты которых колеблются в диапазоне от 1:40 000 до 1:500 000 новорожденных. Описаны также ЛБН, которые встречаются значительно реже. При этом суммарная частота ЛБН составляет 1: 7-8 тыс. новорожденных. Некоторые ЛБН имеют преимущественное распространение в определенных этнических группах, классическим примером которых являются евреи восточно-европейского происхождения.

The main clinical characteristics of a large group of 30 lysosomal storage diseases (LSD), including mucopolysaccharidoses (MPS), sphingolipidoses (SLD), and glycoproteinoses (ILD), are summarized. The purpose of the work is to identify general and particular patterns in the manifestation of LSD. For all LSD, a syndromic nature of the lesion is observed. Almost half of the studied diseases are characterized by a hurler-like phenotype (GPF). The most common clinical manifestations of LSD are neurological anomalies, ophthalmopathies, hearing impairment, hepato- and splenomegaly, hernias, skeletal dysplasia, stiffness and joint contractures. Patients die most often from cardiovascular insufficiency and recurrent infections. Hematological, cutaneous, and nephrological manifestations are observed only in some LSD. For many LSD (63%), clinical polymorphism is typical both in the onset and in the existence of allelic disease series. In almost a third of cases (27%), genetic heterogeneity is noted, so, a similar nature of the course of diseases caused by mutations in different genes. LSD - are rare diseases with frequencies ranging from 1:40,000 to 1:500,000 newborns. Some more rare LSD have also been described. In this case, the total frequency of LSD is 1: 7-8 thousand newborns. Some LSD are predominantly distributed in certain ethnic groups, the classic example of which are Jews of Eastern European origin.
Study of the bacterial microbiome of sputum of patients with lung cancer and its association with chromosome damage in peripheral blood lymphocytes
Authors: Е.Д. Баранова, , В.Г. Дружинин,
Published: January 2023

Микробиом респираторного тракта может оказывать значимое влияние на развитие ряда заболеваний дыхательной системы человека. Помимо дисбиотических изменений в составе микробиома пациентов отмечено, что многие бактерии обладают генотоксическим потенциалом и способны прямо или опосредованно повреждать геном в клетках организма хозяина. Цель исследования - изучить связь между составом микробиома мокроты и уровнем повреждений хромосом в лейкоцитах крови больных раком легкого (РЛ). Изучены таксономический состав бактериального микробиома мокроты, а также базовые частоты хромосомных аберраций (ХА) и микроядер (МЯ) в лимфоцитах крови 66 мужчин с диагнозом РЛ и у 62 здоровых доноров. Результаты секвенирования показали, что микробиом больных РЛ имеет признаки дисбиоза с достоверным увеличением содержания бактерий родов Streptococcus, Bacillus, Gemella и Haemophilus. У пациентов с РЛ выявлена прямая связь между частотой аберрантных метафаз в лимфоцитах и процентным содержанием в мокроте представителей рода Bacteroides.

The microbiome of the respiratory tract can have a significant impact on the development of a number of diseases of the human respiratory system. In addition to dysbiotic changes in the composition of the microbiome of patients, it was noted that many bacteria have a genotoxic potential and are able to directly or indirectly damage the genome in the cells of the host organism. The aim of the study was to study the relationship between the composition of the sputum microbiome and the level of chromosome damage in the blood leukocytes of patients with lung cancer (LC). The taxonomic composition of the sputum bacterial microbiome, as well as the basic frequencies of chromosomal aberrations (CA) and micronuclei (MN) in blood lymphocytes of 66 men diagnosed with LC and 62 healthy donors were studied. The results of sequencing showed that the microbiome of LC patients has signs of dysbiosis with a significant increase in the content of bacteria of the genera Streptococcus, Bacillus, Gemella and Haemophilus. In patients with LC, a direct relationship was found between the frequency of aberrant metaphases in lymphocytes and the percentage of representatives of the genus Bacteroides in sputum.
Variability of Formation Mechanisms of Chromosomal imbalance in Wolf-Hirschhorn Syndrome
Authors: Д.А. Юрченко, , М.Е. Миньженкова, , Ж.Г. Маркова, , А.А. Тарлычева, , Е.Л. Дадали, , Н.А. Демина, , Т.В. Маркова, , И.В. Анисимова, , Н.В. Шилова,
Published: January 2023

Синдром Вольфа-Хиршхорна (WHS, OMIM 194190) - это один из наиболее частых микроделеционных синдромов, представленный гетерозиготной делецией короткого плеча хромосомы 4 (4p16.3). К основным клиническим проявлениям относят характерные черепно-лицевые дизморфии («шлем греческого воина»), пренатальный и постнатальный дефицит роста, задержку психо-речевого развития и судороги. На сегодняшний день описано несколько механизмов формирования делеций 4р16.3 и несколько критических областей, ответственных за фенотипические проявления у пациентов. В нашем исследовании мы представляем пять случаев делеции 4p16.3, имеющей различное происхождение и механизмы формирования.

Wolf-Hirschhorn syndrome (WHS, OMIM 194190) is one of the most common microdeletion syndromes, represented by a heterozygous deletion of the short arm of chromosome 4 (4p16.3). The main clinical features of patients with WHS include: craniofacial features - “Greek warrior helmet”, prenatal and postnatal growth deficiency, developmental disability of variable degree, and seizures. To date, several mechanisms for the formation of 4p16.3 deletions and several critical regions responsible for phenotypic manifestations in patients have been described. In our study, we present five cases of 4p16.3 deletion with different origins and mechanisms of formation.
DETERMINANTS OF E-COMMERCE USER SATISFACTION: THE MEDIATING ROLE OF PURCHASE INTENTION
Authors: Suastiari Ni Kadek Sisi , Mahyuni Luh Putu
Published: January 2023

This study aims to analyze the role of purchase intention in mediating the factors influencing e-commerce user satisfaction. The sample of this study was e-commerce users in Canggu Village, and 240 respondents were used. Data were collected by distributing questionnaires using Google Forms and were analyzed using SEM-PLS. The results show that effort expectancy and trust positively and significantly affect purchase intention. In contrast, performance expectancy and self-efficacy have a negative and insignificant effect. Effort expectancy, intention to purchase, self-efficacy, and trust positively and significantly affect e-commerce user satisfaction, whereas performance expectancy has a negative effect. Intention to purchase can positively and significantly mediate the effect of effort expectancy and trust on e-commerce user satisfaction but not on performance expectancy and self-efficacy. The results of this study indicate that to increase intention to purchase and e-commerce user satisfaction, several things need to be considered, including user trust must be maintained and ease of use must be considered so that users can feel satisfaction with the system.JEL : M21, M13, O33ABSTRAKPenelitian ini bertujuan untuk menganalisis peran intention to purchase dalam memediasi faktor-faktor yang mempengaruhi kepuasan pengguna e-commerce. Sampel dalam penelitian ini adalah pengguna e-commerce di Desa Canggu, sebanyak 240 responden. Data dikumpulkan melalui penyebaran kuesioner dengan menggunakan Google Forms dan . dianalisis dengan menggunakan SEM-PLS. Hasil riset menunjukkan bahwa effort expectancy dan trust berpengaruh positif dan signifikan terhadap intention to purchase, sementara performance expectancy dan self-efficacy berpengaruh negatif dan tidak signifikan. Effort expectancy, intention to purchase, self-efficacy, dan trust berpengaruh positif dan signifikan terhadap kepuasan pengguna e-commerce, sementara performance expectancy berpengaruh negatif. Intention to purchase mampu memediasi secara positif dan signifikan pengaruh effort expectancy dan trust terhadap kepuasan pengguna e-commerce, tetapi tidak untuk performance expectancy dan self-efficacy. Hasil penelitian ini menunjukkan bahwa untuk meningkatkan intention to purchase dan e-commerce user satisfaction, beberapa hal perlu diperhatikan, antara lain trust pengguna harus dijaga dan kemudahan penggunaan harus diperhatikan agar pengguna dapat merasakan satisfaction terhadap sistem.Kata  Kunci : dimensi kepuasan, Intention to purchase, pengguna e-commerce.
STUDENTS' SAVING BEHAVIOUR: WHAT ARE THE MOTIVES THAT INFLUENCE THEM TO SAVE?
Authors: Hartono Ulil , Isbanah Yuyun
Published: January 2023

This study aims to determine the determinants of saving behavior using financial literacy as a mediating variable. The endogenous variable in this study was saving behavior, while the exogenous variables were financial literacy, parental socialization, peer influence, and self-control. The respondents were 300 students from the Faculty of Economics of Indonesia. Data were analyzed by Structural Equation Modelling (SEM) using STATA software. The results show that parental socialization and peer influence positively affect financial literacy, whereas self-control does not. Financial literacy directly affects saving behavior. Parental socialization and peer influence directly influence saving behavior.  The results provide a new understanding of the importance of financial literacy in encouraging student-saving behavior.  The role of parents and peers in the environment is essential for improving students’ financial literacy and saving behavior. The banking industry can play a role in increasing financial literacy through collaboration with universities through a virtual account program and the socialization of savings to students. It is also an opportunity for saving service providers to introduce their products to consumers early.JEL : G41, G410.ABSTRAKTujuan penelitian ini untuk mengetahui determinan dari saving behaviour dengan menggunakan financial literacy sebagai variabel mediasi. Variabel endogen dalam penelitian ini adalah saving behaviour sedangkan variabel eksogen, yaitu financial literacy, parental socialization, peer influence, dan self-control. Responden penelitian ini adalah 300 mahasiswa Fakultas Ekonomi di Indonesia. Data dianalisis dengan Structural Equation Modeling (SEM) menggunakan software STATA. Hasil penelitian menunjukkan bahwa parental socialization dan peer influence berpengaruh positif terhadap financial literacy, sedangkan self-control berpengaruh negatif terhadap financial literacy. Financial literacy juga terbukti berpengaruh secara langsung pada saving behaviour. Parental socialization dan peer influence juga memiliki pengaruh langsung pada saving behaviour. Penelitian ini memberikan pemahaman baru mengenai pentingnya literasi keuangan untuk mendorong perilaku menabung bagi mahasiswa. Peran orang tua dan teman sebaya menjadi faktor penting dalam menumbuhkan literasi keuangan dan perilaku menabung mahasiswa. Industri perbankan dapat berperan dalam meningkatkan financial literacy melalui kerjasama dengan universitas dalam bentuk program virtual account sekaligus untuk sosialisasi tabungan ke mahasiswa. Ini juga menjadi peluang bagi penyedia layanan tabungan untuk memperkenalkan produknya ke konsumen lebih dini.Kata Kunci: literasi keuangan, peer influence, parental socialization, self-control, saving behaviour.
Insights into Cognitive Brain Health in Chronic Kidney Disease
Authors:   Division of Nephrology and Hypertension, Department of Internal Medicine, University of Kansas Medical Center, USA, H Tariq , M Ramakrishnan ,   Division of Nephrology and Hypertension, Department of Internal Medicine, University of Kansas Medical Center, USA, A Gupta ,   Division of Nephrology and Hypertension, Department of Internal Medicine, University of Kansas Medical Center, USA
Published: January 2023

Cognitive impairment and Chronic Kidney Disease (CKD) are common in older adults. With advances in medicine, the average lifespan is expected to increase, further increasing the prevalence of both conditions. The mechanisms underlying cognitive impairment in CKD are unclear. While mild-moderately low estimated glomerular filtration rate (eGFR) may not be associated with cognitive impairment, severely decreased eGFR and albuminuria do. Patients on dialysis have a high prevalence of cognitive impairment. Cognitive function improves after kidney transplantation. However, some residual cognitive deficits persist after transplantation, indicating that restoring the kidney function alone may not be enough to restore cognitive function, and other etiological factors may play a role. Albuminuria, another marker of CKD is also associated with cognitive impairment. However, albuminuria is often undiagnosed. Improving early identification and management of patients with albuminuria may be a good population-based dementia prevention strategy. Other factors associated with cognitive impairment in CKD include anemia and other metabolic derangements commonly observed in CKD. In this article, we reviewed the prevalence of cognitive impairment in CKD, the potential mechanisms underlying cognitive impairment in CKD, and the current evidence on the association between cognitive impairment and eGFR and albuminuria.
Expert Consensus Statements on Smoking Cessation Best Practice in Saudi Arabia
Authors:   Department of Family Medicine, International Medical Center Hospital, Jeddah, Saudi Arabia, A Amir , O Babelli ,   Department of Family Medicine, Ad Diriyah Hospital, Riyadh, Saudi Arabia, A Elhassan ,   Tobacco Control Program, Ministry of Health, Tabouk, Saudi Arabia, A Elnagib ,   Tobacco Control Program, Ministry of Health, Ar’ar, Saudi Arabia, H Turky ,   Department of Family Medicine, Prince Sultan PHCC, Ad Diriyah, Saudi Arabia
Published: January 2023

Background: Each year in Saudi Arabia, approximately 70,000 individuals die from smoking-related diseases and there is an urgent need for practical, evidence-based, best-practice guidance on smoking cessation for healthcare professionals in this country. Methods: A working group of six prominent local practitioners from six medical centers and hospitals across the Kingdom of Saudi Arabia developed a series of consensus statements on current best practice in smoking cessation using available literature and the Delphi technique. Results: Four key topics were identified: Increasing awareness of smoking cessation programs; creating a patient journey that results in high patient satisfaction; Addressing healthcare professional engagement and greater accountability in the delivery of smoking cessation programs; Exploring the role of government/policymakers in shaping smoking cessation programs and providing incentives. Within each of these topics, members were well aligned on the consensus statements after the first round of the Delphi process, with >80% agreement on all statements. The strength of supporting evidence from the literature, including clinical guidelines and best-practice articles in smoking cessation published between 2016 and 2021, was considered ‘strong’ for the majority of the consensus statements. Conclusions: The guidance provided here in the form of consensus statements derived from published data combined with real-world experience aims to provide key stakeholders essential advice on the promotion and delivery of smoking cessation in Saudi Arabia, a country in which tobacco consumption remains high.
The Role of Polycystic Ovarian Syndrome in Chronic Inflammation, Psychological Health, and the Gut Microbiota State: A Case Report
Authors:   Athletic Training Program, Purdue University, USA, CC Davis , JK Popp ,   Athletic Training Program, Purdue University, USA
Published: January 2023

Polycystic Ovarian Syndrome (PCOS) is endocrine and gynecological disorder that affects women of reproductive age. This is a case report of a patient with PCOS who was misdiagnosed and presented with several endocrine and gynecological symptoms. This case emphasizes the need for a holistic healthcare approach to treat the underlying organ dysfunction in women with PCOS. It highlights the interconnectedness between endocrine and reproductive dysfunction. This case report examines the chronic inflammatory state, risk of developing psychological disorders, and gut microbiota diversity in women with PCOS.