bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of symptomatic small bowel stricture in Crohn’s disease by double-balloon endoscopy
Authors: Hu Jing , Wu Juan , Zhang Peipei , Hu Naizhong , Mei Qiao , Wu Xingwang , Han Wei
Published: October 2022

Purpose: To assess the efficacy of double-balloon endoscopy (DBE) for the detection of small-bowel stricture in Crohn’s disease (CD).
Methods: This Tertiary-referral hospital cohort study was conducted between January 2018 and May 2022. CD patients with symptoms of small-bowel stricture were enrolled sequentially. All of the patients were subjected to both computed tomography enterography (CTE) and DBE, and their symptoms of stricture were assessed using the Crohn’s Disease Obstructive Score (CDOS). DBE diagnostic yield was compared to CTE, and the relationship between DBE findings and CDOS was investigated. The factors influencing DBE diagnosis were examined using Cox regression analysis.
Results: This study included 165 CD patients. CDOS scores were higher in 95 patients, while lower in 70. DBE detected 92.7% (153/165) and CTE detected 85.5% (141/165) of the strictures, respectively. DBE diagnostic yields were 94.7% (90/95) in high CDOS patients and 91.4% (64/70) in low CDOS patients (P = 0.13). Patients with a history of abdominal surgery and abscess had a lower diagnosis rate in the multivariate analysis.
Conclusion: DBE has been demonstrated to be an efficient diagnostic method for detecting small-bowel strictures in CD patients. Additionally, there is no difference in diagnostic yields between patients with low and high obstructive scores.
Atom Search Optimization based Load Frequency Control and Firefly Algorithm based cost optimization for an interconnected power system with Renewable Energy Sources
Authors: K Ranjitha , P Sivakumar , A Rajapandiyan
Published: October 2022

To minimize the frequency deviation in a power system containing Renewable Energy Sources, high efficient and robust controllers need to be designed. Maintaining the system frequency and tie-line power in its nominal value is very important to maintain the stability of the power system. For this motive, a novel cascaded controller with Proportional Integral Derivative (PID) and Atom Search Optimized (ASO) PID controller is proposed for load frequency control of a multi-area multi-source power system containing both conventional and renewable generating sources. Further, one of the important Demand side management (DSM) measure, Time of demand (TOD) tariff based cost optimization is done for 62 bus Indian utility system with some renewable energy-based power generation by applying the Firefly algorithm (FA). The Novel ASO can outperform familiar methods and is more competitive with new approaches for parameter estimation and FA has high convergence speed, both these optimizations are faster than other available methods. For analyzing the performance of the controller various test cases are analyzed considering load and source variation. The supremacy of the result of the proposed methodology is demonstrated by comparing the result with classical PID and Fuzzy PID controller for the same system in terms of settling time, peak magnitude and TOD cost.
Different Oxidation Methods on the Wetting and Diffusion Characteristics of 304 Stainless Steel on High Alumina Glass
Authors: SUI Liwei , CHEN Changjun , ZHANG Min
Published: October 2022

This paper presents the influence of different pretreatment methods on the high-temperature wettability of 304 stainless steel and high alumina glass sealing process, including laser surface melting and pre-oxidized treatment. The bonding characteristics of the glass and stainless steel directly depend on the wettability in terms of measured wetting angle, types of oxide formed at the stainless steel surface and microstructural changes during the manufacture process. Comparing quality and thickness of oxide film on the surface of stainless steel to obtain better parameters, and then wetted with high alumina powder at different temperatures. The result shows that pre-oxidized treatment appears a decrease in wetting angle from 56.16° to 33.65°, with laser melted surface showing from 49.76° to 31.54°. XPS shows that surface and adjacent depth have higher concentration of FeO for laser treated stainless steel than that pre-oxidized treated one. SEM reveals that oxide film on the surface is thicker and harder than the pre-oxidized one. This attributes to the oxygen and iron elements can move inward and outward better to form the interface reaction layer. The work shows laser surface melting has a better influence on the wetting and diffusion characteristics of 304 stainless steel onto high alumina glass.
Long-term oncologic outcomes of intersphincteric resection versus abdominoperineal resection for low rectal cancer without preoperative therapy
Authors: Huang Taotao , Hu Mengmu , Lu Xiancheng , Lu Yingjie , Wang Yiran , Pan Yifei , Ni Shicang , Song Huayu , Chang Xu , Ye Lechi , Xiang Youqun , Zuo Zhigui
Published: October 2022

Purpose
This study analyzed the oncologic outcomes of patients with low rectal cancer undergoing intersphincteric resection (ISR) compared with those underwent APR to evaluate the oncologic safety of ISR.
Methods
This study enrolled 149 patients undergoing ISR and 166 patients receiving APR for LRC from January 2010 to December 2020. The exclusion criterion included neoadjuvant therapy or other malignant tumors. Moreover, this study used propensity score matching to reduce possible confounding factors.
Results
After comparing 123 patients from each group, comparable long-run outcomes were observed in both groups. ISR and APR groups showed 5-year disease-free survival rates of 69.8% and 57.2% (p = 0.146), 5-year overall survival rates of 82.8% and 74.4% (p = 0.164), and 5-year local recurrence-free survival rates of 81.8% and 72.0% (p = 0.109), respectively. For paired patients receiving laparoscopic surgery, close outcomes were observed. Moreover, ISR showed comparable oncologic safety for locally advanced cancer to APR.
Conclusions
In this study, ISR and APR showed close oncological results regardless of the surgery approach for patients with LRC without neoadjuvant chemoradiotherapy(nCRT). In addition, this study suggested that ISR may be safe for locally advanced cancer if circumferential resection margins could be ensured negative.
PANC-3 Score in Predicting the Severity of Acute Pancreatitis
Authors: MONICA CHANDRA MOHAN S , SHETTY ABHIJIT S , KUMAR DHANANJAY
Published: October 2022

Background: - Acute pancreatitis is a disease of miscellaneous etiology present as acute abdomen, Inflammatory process of pancreas associated with local and systemic complications. As of now, many scores (such as Ranson’s, APACHE II, Bedside index for severity in acute pancreatitis) that help us in predicting severity at the time of admission. The advantages of the PANC 3 score are to employ widely available tests that are quickly performed and easy to measure. The aim of the present study was to evaluate the efficacy of the PANC 3 score in predicting severity of acute pancreatitis and its relation with the clinical outcome of the disease
Aim and Objective: - PANC-3 score in predicting the severity of acute pancreatitis.
Materials and Methods: -The PANC 3 score was determined by measuring three variables obtained within the first 24 h after diagnosis of acute pancreatitis: 1) Haematocrit; 2) body mass index (BMI); and 3) pleural effusion on the chest X-ray. It is a prospective study in which 60 patients were evaluated with PANC3 Scoring, who were diagnosed with acute pancreatitis and admitted to DEPT OF GENERAL SURGERY, K.S. HEGDE MEDICAL ACADEMY, MANGALORE
Result: - The results showed that PANC3 score had a sensitivity of 80%, and the specificity was 95.5%. The PPV was 85.7%, and the NPV was 93.5%, the diagnostic accuracy is 91% in predicting severe acute pancreatitis.
Conclusion: -PANC3 SCORE is a useful tool to approach and predict the severity of acute pancreatitis, due to its high efficacy, easy application and rapid results, which enables classification of cases and early treatment
The Prevalence of Depressive Symptoms Among Fibromyalgia Patients
Authors: Allahham Amr , Bakkar Batoul , Kikhia Judy , Khalayli Karam , Kudsi Maysoun
Published: October 2022

Background
Fibromyalgia is a noninflammatory musculoskeletal pain disorder which predominantly affects women and is often associated with depression.
Purpose
The main aim of this study was to reveal the depressive symptoms in participants who suffered from fibromyalgia.
Methods
A web-based cross-sectional survey was performed. Five hundred twenty-five women and men with a mean age of 27.12 ± 7.87 years old were recruited. The patients were divided into the case (patients with fibromyalgia) and control (healthy patients). The BDI scores and depression ranges were collected.
Results
8% of participants were found to meet the modified ACR 2010 criteria for FM diagnosis, of whom 85.7% were females. The prevalence of depressive symptoms among participants with fibromyalgia was 90.5%
Conclusion
Patients with FMS had higher BDI scores than healthy controls.
FSCLBF: Feature Selection based on Correlation Label and B-R Belief Function in Multi-label Data
Authors: Mehravaran Zahra , Hamidzadeh Javad , Monsefi Reza
Published: October 2022

In many real-world problems, each sample has over one label, which may also have semantic correlations between labels. However, in multi-label datasets, there are many irrelevant features that impact the accuracy of multi-label learning. Using feature selection to improve accuracy is an effective method. Even though numerous papers have presented novel methods to feature selection, more effort has to be done to improve the accuracy of such methods. This paper presents a novel feature selection method based on correlation labels using a belief function called FSCLBF. Our proposed method increases the accuracy of multi-label learning by considering the correlation labels and the data uncertainty. The proposed method's first step is to select the essential features for each label using a belief function based on a rough set theory (B-R belief function). Then, we identify the equivalent labels according to the overlapping based on their essential features. In the next step, the tag of samples is determined in the set of equivalent labels. Finally, we select the essential features for each equivalent label set, using the B-R belief function by considering the sample differentiation to label. The experimental results show the superiority of FSCLBF to state-of-the-art methods in terms of Hamming loss, One-error, and Accuracy measures.
Dynamic analysis as a method of wells interaction evaluation in making technological decisions
Authors: Abbasova Samira , Mamedova Gulbahar
Published: October 2022

The complexity of developing oil fields determines the creation and improvement of fundamentally new approaches to the analysis and management of various technological processes of oil production based on indirect methods of interpreting current geological and field information for making strategic and tactical decisions to rationalize it.This article discusses the formation of stagnant and poorly drained zones of oil deposits due to the redistribution of hydrodynamic flows of reservoir fluids.

In order to analyze and evaluate the effectiveness of applying the technology to change the direction of filtration flows in the reservoir under consideration, it is necessary to study the influence of non-stationary processes on oil production.

Based on the construction of operational maps of total oil and water production, water cut and the degree of interaction by periods of development, the state of the reservoir system is analyzed and conclusions are made about the characteristic features of the direction of water-oil flows with the subsequent formation of stagnant zones.

The proposed approach to decision-making allows to carry out the dynamic regulation of hydrodynamic flows in order to stabilize and reduce oil production losses for the period under consideration and make the necessary decision on the issuance of technological recommendations for the impact on the operation of the exploitation object, taking into account the minimization of energy and resource costs.

The proposed method was tested on the example of the analysis of the state of development of one of the fields in Azerbaijan, which is in the final stage of development. As an information array, the dynamics of changes in oil and water flow rates by wells in various periods of development was chosen.
Analysis of the main design and operating parameters of the device for the fermentation of bird droppings
Authors: Hajiyev Rovshan , Saidov Rasim , Mammadov Gabil , Taghiyev Urfan , Allahverdiyeva Gahira
Published: October 2022

The study on the utilization of poultry droppings put forward the need for the constructive and technological improvement of the biofermentation device. A drum-type bioreactor better meets the requirements for the technological process of eco-friendly biologically active fertilizer production from livestock and poultry wastes. However, the great size of the heat transfer surface of the bioreactor drum and its significant ejection momentum during spinning require quite a lot of energy. To decrease this consumption, the main constructive parameters should be optimized. The main reason is the sharp increase in prices for mineral fertilizers, the weak economic condition of most farms, the lack of advanced processing technologies and the use of organic fertilizers.

Our aim in these studies was to analyze the types of design and operating parameters of the device for the fermentation of bird droppings. To this end, we conducted a study on the disposal of bird droppings, and also put forward the need for constructive and technological improvement of the biofermentation device. One of such ways to solve the problem was a drum-type bioreactor, which, according to our research indicators, better meets the requirements for the technological process of producing environmentally friendly biologically active fertilizers from animal husbandry and poultry waste, however, the size of this equipment of the heat transfer surface of the bioreactor drum and its significant emission pulse during rotation require a rather large waste of energy. To reduce this consumption, it is necessary to optimize the basic design parameters.

Devices that work continuously were recognized as the most promising. They fully meet the technological and operational requirements
Study of the laser radiation effect in combination with doxorubicin on the survival of MCF7 and MCF7DOX culture cells
Authors: Konovalenko Sergii , Lykhova Oleksanra , Chepurna Oksana , Prokopenko Igor , Naleskina Lesia , Chekhun Vasyl
Published: October 2022

The use of lasers in oncology is constantly evolving. In recent years, the mechanisms of the effect of laser radiation, particularly of the infrared spectrum, on tumour cells in combination with various chemotherapeutic agents have been studied.

The aim. To study the effect of laser radiation with a wavelength of 660 and 810 nm on the survival of tumour cell cultures MCF7 and MCF7DOX in the presence of doxorubicin.

Materials and methods. Tumour cells of MCF7 and MCF7DOX cultures were cultured in DMEM medium (Biowest, France) with 10 % fetal calf serum (FST) (Biowest, France) and 40 μg / ml gentamicin (Sigma, USA). Doxorubicin was added to the cells to a final concentration of 1 μg / ml. Cells were irradiated with a laser (Photonica-Plus, Ukraine) with a wavelength of 660 and 810 nm (irradiation time – 5 min, power density – 50 mV/cm2, irradiation dose 15 J/cm2). The results were recorded using a multiwell spectrophotometer (Labsystems Multiskan PLUS, Finland). Photomicrographs of cells were taken using a Carl Zeiss microscope, Germany.

Results. Cell survival assessment and morphological characteristics in micropreparations indicate the antitumor efficacy of the combined effects of laser irradiation and doxorubicin. The most pronounced cytotoxic effect on MCF7-DOX culture cells was caused by doxorubicin exposure for 90 min in combination with infrared laser irradiation (λ=810 nm).

Conclusions. Infrared laser light synergises with the toxic effects of doxorubicin and creates favourable conditions for apoptosis of tumour cells, as evidenced by cytomorphological data.
Determination of technological parameters of obtaining stevia extract
Authors: Belemets Tatiana , Kuzmyk Uliana , Gryshchenko Roman , Osmak Tetiana
Published: October 2022

The prospects for the use of a plant raw material – stevia as a natural sweetener for obtaining sweet extracts have been substantiated. Literary research has been conducted on the expediency of carrying out preparatory operations of stevia-raw material in order to intensify mass exchange processes during extraction; their necessity has been theoretically justified.

A number of studies have been conducted with the aim of intensifying the process of extracting the dry mass of stevia leaves. Preliminary preparation of stevia was carried out – crushing (using a laboratory crusher – A1-DM2R) and subsequent sieving to the average size of the leaf fraction – 3.9±0.1 mm.

It is proposed to use whey from the production of sour milk cheese to obtain sweet extracts of stevia for their further use in the food industry.

It has been established, that the highest efficiency of the extraction process of the prepared dry stevia leaf mass is achieved with a hydromodule – 1:15. Carrying out the process under these conditions allows to achieve the highest degree of extraction of extractive substances – 29.9.

The results of the experimental studies, obtained and presented in the article, can be used to carry out further physicochemical analyzes of the quality of the obtained stevia extracts and the possibility of combining them with a milk base to obtain a dietary range of food products
The Impact of COVID-19 on Gametes and Endometrium:	A Narrative Review
Authors: Karatas Esra , Gunes Ali Can , Temiz Bilal Esat , Mumusoglu Sezcan , Bozdag Gurkan
Published: October 2022

The Coronavirus disease 2019 (COVID-19) has been affecting our lives since December 19. Naturally, during the COVID-19 outbreak, it has become a point of interest whether severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection might affect oocyte, and sperm and influence the implantation during the assisted reproductive technology cycles. In the current narrative review, we aimed to scrutinize articles about SARS-CoV-2 infection and infertility concerning the safety of gametes and the endometrium. Whereas the available data suggest that SARS-CoV-2 interferes with various types of molecular pathways in the oocyte, spermatozoa, and endometrium, the lack of co-expression in angiotensin-converting enzyme 2 and transmembrane protease serine 2 in those cell lines theoretically avoid concerns by patients and reproductive endocrinologists. However, one should consider that those observations were based on a few case series and should be confirmed with further observational studies including a larger sample size with various clinic spectrums. Alternative pathways that can be utilized by the virus to invade gametes and individual differences in molecular expression are other potential limitations that should be considered.
ПОТЕНЦИАЛ ОСНОВНЫХ СОЦИОКУЛЬТУРНЫХ ИНСТИТУТОВ В ФОРМИРОВАНИИ И РАСПРОСТРАНЕНИИ ИДЕОЛОГЕМЫ СЕМЬИ
Authors: ОРЛОВА Е.М. , ШАПОВАЛОВА Ю.П.
Published: October 2022

The article analyzes the role and place of the main socio-cultural institutions in the formation and spread of the family ideologeme, which allows us to establish that the main institutions of inculturation involved in the formation and spread of the family ideologeme include such paternalistic institutions as education and religion, which ensure the reproduction of the dominant family ideologeme. marriage culture, propaganda institutions in the form of mass media and advertising, which provide a constant targeted impact on the population in order to establish a certain way of family life and behavior in the marriage market, as well as such informal institutions as online communities and the family, which ensure the transmission of life experience in family and marriage sphere from the older generation to the younger, from peers to peers.
Исследование условий независимой жизнедеятельности инвалидов – студентов медицинского вуза
Authors: Провоторова Е.Д. , Непочатых Е.П.
Published: October 2022

The article presents the results of a study of the conditions of independent life of disabled students of a medical university. The results of the study revealed the existence and functioning of a system of comprehensive support and comprehensive provision of conditions for the accessibility of educational services for people with disabilities; the results of the survey revealed a high degree of autonomy and independence of students with disabilities at the medical university; the demand among disabled students for support technology in the framework of the organization of the educational process of the university.
Анализ социальной среды г. Курска для инвалидов по зрению
Authors: Кузьмин В.П. , Брагина В.А.
Published: October 2022

The article presents the results of the analysis of the study of the social environment of the city of Kursk for the visually impaired; describes the barriers for the visually impaired in the city of Kursk; the features of the formation of an accessible environment for the visually impaired are presented. The study was conducted on the basis of the All-Russian Society of Blind People in Kursk.
Temperature effect on the structural features of j.3-glycosidase from sulfolobus solfataricus. an infrared study
Authors: D'Auria Sabato , Rossi Mose , Nucci Roberto , Bertoli Enrico , Tanfani Fabio
Published: October 2022

In this paper we report the temperature effect on the structural properties of a thermostable 13-
glycosidase isolated from archaeon Sulfolobus solfataricus monitored by infrared spectroscopy. The
investigations were carried out at pH 10, because at neutral pH's values the llenaturation process did
not take place. The denaturation process was irreversible and sodium dodecyl sulfate additions to the
enzyme solution caused a lower temperature and a lower onset of the protein denaturation.
Striking structural resemblance between small cysteine-rich proteins with diverse functions
Authors: Geerestein-Ujah E.C. Van , Breg J.N. , Sarda L. , Cozzone P.J. , Kaptein R.
Published: October 2022

We have established a striking structural resemblance between the two domains of procolipase and several other small cysteine-rich proteins of diverse functions. The proteins share a common scaffold although the sequence homology, apart from the cysteine pattern is quite low. The descriptions we delineate here should provide further constraints for use in the design of stable functional small proteins for pharmaceutical and chemical applications.
Preliminary x-ray crystallographic analysis and molecular replacement studies with 2,5-diketo-d­ gluconate reductase
Authors: Blaber Michael , Khorana Sumit , Powerst Davd B. , Andersont Stephen
Published: October 2022

2,5 diketo-D-gluconate reductase (2,5-DKG reductase) is an enzyme with considerable commercial interest because it can be used to manufacture 2-keto-L-gulonic acid, a key intermediate in the industrial synthesis of L­
ascorbic acid. This protein was crystallized in the monoclinic space group P21 with one molecule in the asymmetric unit. The crystals diffract to a maximum resolution of 1.9 A. An x-ray intensity data set was collected from these crystals and is 85% complete between 60 to 2.1 A. An initial structure solution has been attempted using the molecular replacement method with human aldose reductase (38% sequence identity) as a search model. The rotation and translation function searches yield a single clear peak above the background
noise level with a corresponding R factor of49.2% and a correlation coefficient of34.0%.
Interaction of a partial calmodulin-binding domain of caldesmon with calmodulin
Authors: Zhang Mingjie , Voge Hans J.
Published: October 2022

Caldesmon (CaD) is associated with the thin filaments of smooth muscle tissues. Limited proteolysis studies of CaD reveal that the sequence w659 EKGNVF is involved in binding the calcium-regulatory protein calmodulin (CaM). Using transferred nuclear Overhauser enhancement NMR measurements, we have found that the 8 and 11
residue synthetic peptides KS(MWEKGNVF)S bind with an a-helical structure to CaM. Proton NMR titration studies show that a 2:1 peptide to CaM complex is formed, suggesting that the two domains of the dumbbell-shaped CaM can bind one equivalent of peptide each with similar binding constant.
Introduction of trypsin specificity into chymotrypsin inhibitor ii
Authors: Leatherbarrow Robin J. , Hasan Zulfiqar
Published: October 2022

A unique cysteine residue was introduced into the P1 pos1t1on of chymotrypsin inhibitor II (CI2) by
- Jigonucleotide-directed mutagenesis (Met59 Cys). Chemical modification of CI2M59C with 2- bromoethylamine, 3-bromopropylamine and 2-mercaptoethylamine resulted in the introduction of lysine-sulfur analogues at the P1 position. Unlike the original CI2, all three modified inhibitors exhibited moderate but effective inhibition of trypsin. The results demonstrate that genetic and chemical modification can be successfully combined to tailor inhibitory specificity.
Long-term Follow-up of Patients With Hernia Using the Hernia-Specific Quality-of-Life Mobile App: Feasibility Questionnaire Study
Authors: Huang Ching-Shui , Tai Feng-Chuan , Lien Heng-Hui , Wong Jia-Uei , Huang Chi-Cheng
Published: October 2022

Background

Hernia repair is one of the most common surgical procedures; however, the long-term outcomes are seldom reported due to incomplete follow-up.

Objective

The aim of this study was to examine the use of a mobile app for the long-term follow-up of hernia recurrence, complication, and quality-of-life perception.

Methods

A cloud-based corroborative system drove a mobile app with the HERQL (Hernia-Specific Quality-of-Life) questionnaire built in. Patients who underwent hernia repair were identified from medical records, and an invitation to participate in this study was sent through the post.

Results

The response rate was 11.89% (311/2615) during the 1-year study period, whereas the recurrence rate was 1.0% (3/311). Causal relationships between symptomatic and functional domains of the HERQL questionnaire were indicated by satisfactory model fit indices and significant regression coefficients derived from structural equational modeling. Regarding patients’ last hernia surgeries, 88.7% (276/311) of the patients reported them to be satisfactory or very satisfactory, 68.5% (213/311) of patients reported no discomfort, and 61.1% (190/311) of patients never experienced mesh foreign body sensation. Subgroup analysis for the most commonly used mesh repairs found that mesh plug repair inevitably resulted in worse symptoms and quality-of-life perception from the group with groin hernias.

Conclusions

The mobile app has the potential to enhance the quality of care for patients with hernia and facilitate outcomes research with more complete follow-up.
vaccination coverage of patients hospitalized for dermatoses requiring biotherapy at the
dermatology department CHU Ibn Sina rabat (Preprint)
Authors: daakir hajjar , senouci karima , benzekri laila , Ismaïli nadia , meziane mariame
Published: October 2022

BACKGROUND

several studies affirm the essential role of anti-influenza and anti-pneumococcal vaccination in
immunocompromised patients or receiving systemic immunosuppressive treatment including biotherapy

OBJECTIVE

to evaluate the anti-influenza and anti-pneumococcal vaccination coverage in our patients who are candidates for biotherapy as well as the possible side effects of this vaccination

METHODS

a prospective study, over 2 years (between July 2019 and July 2021) at the CHU Ibn Sina dermatology department in Rabat, Morocco with follow-up of these patients hospitalized for biotherapy who received anti-influenza and anti-pneumococcal vaccination

RESULTS

a prospective study, over 2 years (between July 2019 and July 2021) at the CHU Ibn Sina dermatology department in Rabat, Morocco with follow-up of these patients hospitalized for biotherapy who received anti-influenza and anti-pneumococcal vaccination

CONCLUSIONS

anti-influenza and anti-pneumococcal vaccination in our patients who are candidates for biotherapy is systematic and safe
Matrix of Evidence Tool: Assessing the quality of real-world study designs (Preprint)
Authors: Hess Lisa M , Goetz Iris , Muehlenkord Alex , Siebert Uwe
Published: October 2022

BACKGROUND

There are a variety of study designs that utilize real-world data. To date, there are limited resources available to aid in the selection and evaluation of these study designs to answer important research and policy questions and differentiating between study designs may be challenging for those new to the field of outcomes research.

OBJECTIVE

Therefore, an interactive tool was built based on published methodologic evidence to fill this gap.

METHODS

The published literature review was evaluated to identify publications related to study designs that utilize real-world data: specifically, pragmatic trials, prospective and retrospective observational studies, and cross-sectional designs. Data from these publications were extracted by two reviewers and qualitatively synthesized to identify themes. These themes were then assembled to build an interactive tool for researchers and decision makers of studies using real-world data. This tool underwent external evaluation and revision in an iterative process to build the final Matrix of Evidence Tool.

RESULTS

The major themes (and subthemes) identified from the literature included data issues (access and data quality), generalizability, outcomes (usability for decision making, long-term outcomes, rare events, specificity of measurement, causal inference), operational issues, bias (compliance, misclassification of exposure, misclassification of outcome, participant selection bias, immortal time bias), and confounding. The Matrix of Evidence tool was built to communicate these themes and is a resource that can be used to evaluate the potential of a particular real-world study design to maximize various aspects of research.

CONCLUSIONS

The key themes identified in the published literature can be evaluated across real-world designs by using the Matrix of Evidence tool. While all aspects of real-world research are not feasible to include, the primary differentiating factors across four common real-world designs are evaluated and compared. Researchers may find this tool valuable in the selection of an appropriate real-world study design given the research question and intent of use of the resulting evidence.
A Gamified Real-time Video Observed Therapies (GRVOTS) Mobile App via the Modified Nominal Group Technique: Development and Validation Study (Preprint)
Authors: Abas Siti Aishah , Ismail Nurhuda , Zakaria Yuslina , Ismail Ismassabah , Mat Zain Nurul Hidayah , Yasin Siti Munira , Ibrahim Khalid , Razali Asmah , Mohd Yusoff Mas Ahmad Sherzkawee , Ahmad Norliza , Chinnayah Thilaka
Published: October 2022

BACKGROUND

The success rate of tuberculosis (TB) treatment in Malaysia remains below the recommended World Health Organization target of 90% despite the implementation of directly observed therapy, short-course, a physical drug monitoring system, since 1994. With increasing numbers of patients with TB in Malaysia defaulting on treatment, exploring another method to improve TB treatment adherence is vital. The use of gamification and real-time elements via video-observed therapies in mobile apps is one such method expected to induce motivation toward TB treatment adherence.

OBJECTIVE

This study aimed to document the process of designing, developing, and validating the gamification, motivation, and real-time elements in the Gamified Real-time Video Observed Therapies (GRVOTS) mobile app.

METHODS

The modified nominal group technique via a panel of 11 experts was used to validate the presence of the gamification and motivation elements inside the app, which were assessed based on the percentage of agreement among the experts.

RESULTS

The GRVOTS mobile app, which can be used by patients, supervisors, and administrators, was successfully developed. For validation purposes, the gamification and motivation features of the app were validated as they achieved a total mean percentage of agreement of 97.95% (SD 2.51%), which was significantly higher than the minimum agreement score of 70% (P<.001). Further, each component of gamification, motivation, and technology was also rated at 70% or more. Among the gamification elements, fun received the lowest scores, possibly because the nature of serious games does not prioritize the fun element and because the perception of fun varies by personality. The least popular element in motivation was relatedness, as stigma and discrimination hinder interaction features, such as leaderboards and chats, in the mobile app.

CONCLUSIONS

It has been validated that the GRVOTS mobile app contains gamification and motivation elements, which are intended to encourage medication adherence to TB treatment.
The Trend of COVID-19 Vaccination Rate and Its associated factors: a multicenter household survey (Preprint)
Authors: Wu Jian , Li Quanman , Tarimo Clifford Silver , Wang Meiyun , Miao Yudong
Published: October 2022

BACKGROUND

Vaccination against COVID-19 has saved tens of thousands of lives worldwide since its introduction. However, with time elapsing, improving the vaccination coverage in China may be confronted with a number of obstacles.

OBJECTIVE

In this nationwide study, we aimed to evaluate the COVID-19 vaccination rate and its potential influencing factors in the Chinese population.

METHODS

We collected data from the national multicenter household survey in China using a stratified random sampling method from 3 Aug. 2022 to 14 Aug. 2022. We recruited respondents aged 18 years or older in the selected households. We investigated the variation in the COVID-19 vaccination rate for the first dose, full dose as well as the booster vaccine, and identified the associated factors for vaccination using multiple logistic regression models.

RESULTS

A total of 6781 participants (2556 households) were included in this study. Up to 14 Aug. 2022, 6613 participants (97.52%, 95%CI: 97.15%-97.89%) received the first dose of COVID-19 vaccines; 6319 participants (93.19%, 95%CI: 92.59%-93.79%) received the full-dose vaccines while 5435 participants (80.15%, 95%CI: 79.20%-81.10%) received the COVID-19 booster vaccines. Participant’s age, chronic disease status and self-efficiency were found to be significant influencing factors for receiving first dose vaccine, full dose vaccine and booster dose vaccine for COVID-19. Ineligibility for vaccination was the primary reason that participants did not receive the booster vaccine (74.98%). This is followed by vaccination safety concerns, which make up 8% of all the highlighted reasons.

CONCLUSIONS

China has surpassed initial targets of WHO's Global COVID-19 Vaccination Strategy. To increase vaccine coverage, policymakers should develop more specialized measures for special groups, including young adults, people with chronic disease, and those with low self-efficacy.

CLINICALTRIAL

Not applicable.
Telemedicine and Quality: A Systematic Review (Preprint)
Authors: Kruse Clemens , Molina-Nava Anna , Kapoor Yajur , Anerobi Courtney , Maddukuri Harshita
Published: October 2022

BACKGROUND

Telemedicine has a long history, but its efficacy has been reported with mixed reviews.

OBJECTIVE

To analyze the effectiveness of telemedicine through the six domains of quality through an analysis of RCTs in the literature published in 2022.

METHODS

Four databases were queried with a standard Boolean string. The 882,420 results were reduced to 33 for analysis. The systematic literature review was conducted in accordance with the Kruse Protocol and reported in accordance with PRISMA (2020).

RESULTS

A kappa statistic was calculated to show agreement between reviewers (k=0.90, strong). Medical outcomes associated with the telemedicine modality were 100% effective with a weighted average effect size of 0.21 (small effect). Many medical outcomes were positive but not statistically better than treatment as usual. RCTs reported positive outcomes for physical and mental health, medical engagement, behavior change, increased quality of life, increased self-efficacy, increased social support, and reduces costs. All six domains of quality were identified in the RCTs, but four were identified in 100% of the studies. Telemedicine is highly patient-centered because it meets a digital preference, is convenient, avoids a stigma, and enables education at ones’ own pace. A few barriers exist to its wide adoption such as staff training, cost, and it may not be the preferred modality for all.

CONCLUSIONS

Telemedicine’s effectiveness is equal to or above traditional care across a wide spectrum of services studied in this systematic literature review. Providers should feel comfortable offering this modality of care as a standard option to patients where it makes sense to do so. While barriers do exist for wide adoption, the facilitators are all patient facing.
Impacts and Industrial Applications of Phytic Acid and Phytase
Authors: Prajapati Madhvi , Shah Hardik
Published: October 2022

Phytic acid is an antinutritional compound that chelates P and essential divalent cations such as Fe, Ca, and Zn in cereals and major staple crops such as wheat, maize, rice, and sorghum. As a result, these cations cannot be absorbed by monogastric animals or humans: phytic acid has an inhibitory effect on nutrient uptake and its levels are negatively correlated with protein and starch digestibility. However, phytic acid can be degraded by the action of the enzyme phytase. Phytase plays important roles in the degradation of phytic acid and in increasing the nutritional quality of staple foods. Microbial phytase is a versatile enzyme that is beneficial for humans, animals, the environment, and the industry. In this review, we summarise the interaction of phytic acid with micronutrients, various approaches to enhancing the nutritional profile of staple foods by reducing the phytic acid content, and current knowledge of microbial-based phytase as a potential reducer of phytic acid.
Prognosis of Human Cytomegalovirus in Cancer Patients Undergoing Chemotherapeutic Treatment in Egypt and an Emergent Prevalence of Glycoprotein B-5
Authors: Shamsia Israa S. , Abozahra Rania , Baraka Kholoud , Shmeila Ayman Abou , Abdelhamid Sarah M.
Published: October 2022

The human cytomegalovirus (HCMV) is a global opportunistic β-herpes virus causing severe diseases in immune-compromised patients, such as malignant tumor patients, especially those undergoing chemotherapeutic treatment. This study aimed to determine the prevalence of HCMV-DNA in chemotherapeutic treatment naive cancer patients, and after chemotherapy, to compare between conventional nested PCR and ELISA techniques for the detection of HCMV, and to detect glycoprotein B genotypes. Plasma and serum samples before and after three chemotherapy cycles were collected from 49 chemotherapy-naive cancer patients. DNA was extracted from plasma samples using QIAamp® DNA Mini kit. HCMV-DNA was detected using a nested PCR technique. Multiplex nested PCR was used for HCMV-glycoprotein B (gB) genotyping. HCMV-IgG and -IgM were detected using ELISA technique. Thirty one (63.3 %) of the 49 plasma samples of the chemotherapy-naïve cancer patients were positive for HCMV-DNA; 21 of which remained positive after chemotherapy. However, 18 samples were negative of which 16 became positive after chemotherapy. gB-5 was the most common glycoprotein genotype detected (80.6 %), followed by gB-1, gB-3, gB-4, and gB-2. HCMV IgG was detected in the 49 serum samples of chemotherapy-naïve patients, and after exposure to chemotherapy. HCMV-DNA is commonly identified in cancer patients. Its detection after chemotherapy exposure may suggest HCMV reactivation. The most common genotype detected in cancer patients in Egypt is gB-5 in contrast to earlier research. IgG was detected in all patients. This indicates that HCMV is endemic in Egypt, necessitating the development of public awareness campaigns about HCMV infection and preventive strategies.
Improved Accuracy of Brain Tumor Detection Using VGG16
Authors: Chowdhury Asmita
Published: October 2022

Abstract: Brain tumor is a very serious problem of human life. In recent years, brain tumors have become one of the leading causes of death among people. It is difficult to identify the tumor itself. Direct detection and classification of brain tumors has the potential to achieve high efficiency and high levels of prognosis. However, it is well known that the accuracy of automatic identification and classification techniques varies from one technique to another and depends on the nature of the image. For the diagnosis and classification of brain tumors, MRI images have been very useful in recent years. MRI images allow us to diagnose brain tumors. This paper highlights the techniques of CNN and has worked upon VGG16 model.
Investigation of Airfoil Design and Analysis
Authors: . Sundram , Kumar Rahul
Published: October 2022

Abstract: In this project “Aerofoil Design and Analysis” an attempt has made to make a complete study on lift and drag coefficient of various aerofoil sections using CFD. The primary goal of this project is to learn and analyse the aerodynamic performance of wings. The objective of this study is to improve aerofoil design using the software CATIA, And Fluent Analysis using the software ANSYS. Aerofoil is a principal part of any airplane construction. How much lift force and drag force is sufficient to balance the weight of the plane is decided by the aerofoil. Aerofoils are basically divided into two categories - they are Asymmetrical and Symmetrical aerofoils. Based on their drag and lift coefficient’s variation with angle of attack, stall angle of attack and magnitude of the coefficients they are divided. Here the NACA aerofoil is modified by adding dimples on the upper half of the wing and compared with the simple one. The comparison is made on different speed and pressure on the wing and the coefficient of lift and drag.
Subscription Management SaaS-based System
Authors: Shaikh Mujtaba , Shaikh Muskaan , Beddingwala Kaizad , Khan Jabin , Gautam Hrithik , Khan Hamza , Pirani Dr. Zainab
Published: October 2022

Abstract: Btag is a Cloud-Based Web App that is designed to maintain the membership of any subscription-based business. The problem of management is not unknown in the world of business. We have to make sure that such problems are resolved to boost economic growth and to also add more businesses to the grid. Btag software does that for us. We have thought and analyzed through all possible lenses how to build good membership-based software. The system does what it's made for. The system will store the data of all the members. The member data includes the name, Aadhaar number of the user, sex, phone number, email, and status. There are three different statuses of any member which are Enquiry, Active and Inactive. At any given time a member will be in either of these three statuses. Each status denotes certain characteristics that help the business in better management. If the user has come for the very first time then the user will be in the Enquiry mode given the member hasn't paid yet. Once the member pays the status changes to Active. If the member has any dues then the status will change to Inactive. One can also search all the different members in the ecosystem based on different criteria which are as follows status, sex, name, phone number, etc. Based on the data collected by the user and the payment trends. This work also gives us statistics and relevant data which can help a business in driving sales. This will help revolutionize the subscription-based business scenario.
Analysis of Various Topologies and Control Circuit used in Single Phase EV Charger
Authors: Tripathi Ashish , Letha Shimi Sudha
Published: October 2022

Abstract: In remote electric vehicle charging frameworks utilizing inductive power transfer (IPT), power electronic converters assume a basic part in decreasing size and cost, as well as boosting the proficiency of the whole framework. As of late, analysts have led huge examination studies to work on the exhibition of power transformation frameworks, including power converter topologies and control plans. Incorporated On-Board Battery Chargers (OBC) have been acquainted as ideal arrangement with increase of electric vehicle (EV) market penetration and limit the general expense of EVs. OBCs are by and large arranged into triphasic and monophasic types with unidirectional or bidirectional power stream. Existing electric vehicle (EV) chargers utilize a hard-core non-linear diode bridge-rectifier (BR) to exploit the DC volt at the contribution of the DC converter and acquaint quality of the power is a counted as a problem with the AC input. These problems insist improvement in Power Quality for existing battery charger for this purpose the bridgeless Cuk Converter is used with the flyback converter. Cuk Converter used single diode and switch and provide additional advantage like reduction in the switch volt-stress and higher efficiency equated to the other conventional bridgeless (BL) converters. Similarly, bridgeless isolated Zeta-Luo converter with PF correction is also used. The Zeta and Luo is functioned for the half cycle of the supply individually and give the benefits of the both topologies. In this paper BL Zeta, BL Cuk, BL Buck-Boost, BL Luo, BL Single Ended Primary Inductance Converter (BL SPIC), and Canonical Switched Cell (CSC) converters are reviewed.
Governance and regulation of aligning ISO 37001 in mitigating corporate bribery risks
Authors: Rozah Umi , Pujiyono Pujiyono
Published: October 2022

The purpose of this paper is to examine how corporate social responsibility (CSR) and good corporate governance (GCG) can reduce the occurrence of bribery cases in companies. The research object for this study was ISO 37001. The theoretical foundations used for this study were adopted from Veselovská, Závadský, and Závadská (2020) and Méan and Gehring (2018), focusing on the implementation of ISO 37001 to mitigate bribery risks in reinforcing CSR. A qualitative research method produces descriptive data in words and notes related to meaning, values, and understanding with a doctrinal and social approach. The socio-legal research approach is used to explore primary data in the form of values and interpret the behavior of corporations and legal institutions with an interest in preventing corruption by corporations. The results reveal that the implementation of GCG in the company will minimize the opportunistic nature of management so that it has an impact on improving company performance and supporting the prevention of bribery in company performance. Likewise, the role of a good organizational culture is very important in anticipating opportunistic behavior from a handful of parties who still commit bribery for their own interests and harm other parties