bluuebunny/crossref_metadata_2025 huggingface dataset:
Two decades of learning agility and an integrated framework: a review of literature and bibliometric analysis
Authors: Nayak Lagna , Malik Pooja
Published: May 2024

Purpose

Due to the extremely complicated and unpredictable outside world, using and unlocking the potential of learning agility (LA) has become a key part of making businesses more competitive, and there is a lot of new research being produced on this topic very quickly. Thus, this study aims to carry out a bibliometric analysis to systematically analyse the existing literature on LA and propose an integrated framework depicting various predictors, mediators and outcome variables covered in the LA research. Moreover, this study lays out a rich and detailed agenda for future research and enhances understanding of LA by suggesting future research questions.

Design/methodology/approach

This study applied bibliometric analysis using the Scopus database. This study applied bibliometric analysis and cluster analysis to examine the contributions of research constituents (authors, institutions, countries and journals) and their structural and thematic relationships (co-citation network and thematic trends). The most important insights were used to propose an integrated conceptual model.

Findings

Based on the results of the performance analysis, this study discovered that the USA is the most productive country in this research field, followed by Belgium, Australia, Korea and India. In addition, the findings highlight the most prominent journals, authors and countries contributing to LA, document citations and theories contributing to the field of LA. This study identifies four emerging future research themes (clarity of construct, identification of variables to be studied with LA, strategies enhancing LA and context of study) and proposes subsequent research questions using science mapping analysis.

Practical implications

A review of existing literature on LA provides a clear understanding of the current and future state of research on this topic. And, from a practical standpoint, this study highlights emergent clusters that will help practitioners build LA as a tactical reaction to the current volatile, uncertain, complex and ambiguous environment.

Originality/value

This study is relevant as it aims to systematically review articles on LA and proposes an integrated conceptual framework based on existing literature that will serve as a guide for existing and future research in this area.
Impact pathways: a call for impactful research in supply chain GHG emissions reduction
Authors: Ellram Lisa M. , Tate Wendy L.
Published: May 2024

Purpose

This impact pathway manuscript motivates and guides operations and supply chain management (OSCM) researchers to deeply consider the role of suppliers in greenhouse gas (GHG) emissions reduction. It prompts a reconsideration and update of their understanding of climate change in their research and the positive influence that research could have, specifically on reducing GHG emissions and slowing climate disasters.

Design/methodology/approach

The authors use qualitative research methods, including a literature review, interviews with NGOs, focus groups with purchasing professionals and in-depth case studies.

Findings

The results provide insights into purchasing’s role in the engagement of suppliers in GHG emissions reduction efforts as organizations begin to advance the sustainability journey toward suppliers’ emissions reduction and their contribution to improvements in supply chain GHG emissions. The paper calls for more actionable academic research that can contribute to theory and practice.

Research limitations/implications

This impact pathway article discusses how the topic of GHG supply chain emissions reduction is viewed in both research and practice. The current dire state of the environment and purchasing and supply chain involvement in GHG emissions reduction initiatives points to the need to develop impactful research. The paper closes with guidance on potential future research opportunities.

Practical implications

The pressure on companies to reduce their GHG emissions has never been more significant, and companies have never before made as many public commitments to reduce their GHG emissions both internally and across the supply chain as they are making today. Managers must truly understand their role in reducing GHG emissions and their supply chain implications.

Social implications

GHG emissions reduction and associated climate change are top issues on the global climate agenda. Reducing emissions (and related climate change) has important positive implications for human health. This is especially true among underrepresented communities, which tend to be disproportionately impacted by living and working in weather-exposed climates with poor air quality.

Originality/value

The authors aim to stimulate new research and discussion through this pathway paper. The climate crisis is real, and the world is missing its GHG reduction targets. If companies limit their efforts and continue to make excuses, the world will continue its path to climate disaster.
How does digital government affect energy efficiency?
Authors: Xu Huijie
Published: May 2024

Purpose

The rapid development and high penetration of digitalization have triggered profound changes in the energy sector. The purpose of this study is to integrate the government digital transformation into the analysis framework and discuss its impact on urban energy efficiency and its realization mechanism.

Design/methodology/approach

Using the “Information Benefit Pilot City” (IBC) policy as a quasi-natural experiment, and drawing on data from 285 prefecture-level cities in China from 2008 to 2019, this paper discusses how digital government affects urban energy efficiency by using difference-in-differences (DID).

Findings

The results show that digital governance significantly improves energy efficiency, and this conclusion remains reliable even after a series of robustness tests, endogeneity processing and sensitivity analysis. Heterogeneity results show that resource-based, eastern, high economic development level and high urbanization rate city digital government construction are more conducive to improving energy efficiency. The mediating effect shows that the influence mechanism of digital government on energy efficiency mainly includes reducing carbon emission, promoting green technology innovation and attracting talents.

Originality/value

(1) From the perspective of government digital transformation, this study supplements the way to improve energy efficiency and also expands the social dividend of government governance transformation. (2) Through quasi-experimental analysis of IBC policy, this paper solves the problem of difficulty in quantifying the government's digital transformation indicators. (3) The impact heterogeneity and realization mechanism are further discussed and the specific ways of digital government's impact on energy efficiency are revealed.
Effect of defatted Lagenaria siceraria (Molina) Standley seed flour as a fat replacer on physicochemical, technological, and sensory properties of beef patty
Authors: Noumo Ngangmou Thierry , Johny Lidiya C. , Mbougueng Pierre Desire , Sokamte Tegang Alphonse , Tatsadjieu Ngoune Leopold , Suresh P V , Mbofung Carl Moses F.
Published: May 2024

Defatted Lagenaria siceraria seed flour (DLSSF) was obtained from defatted seed cake, dried, and ground through a sieve of 500 μm and characterized. A 2 × 4 factorial design (two flour hydration rates and four fat substitution rates) was used to produce a low‐fat beef patty by replacing fat with DLSSF. Beef kidney fat was used to formulate the control sample. Chemical, physical, technological, sensory, and nutritional characteristics of low‐fat beef patties manufactured were evaluated. DLSSF contains mainly protein. As fat replacers, DLSSF induces a significant increase in the pH of the raw and cooked patty, the moisture and protein contents, the cooking yield, the cohesion, chewiness, springiness, and lightness of the cooked beef patty with fat substitution rate. There is a decrease in fat content, total calories, water retention capacity, hardness, and redness of the cooked patty with a fat substitution rate. From the sensory analysis, the substitution of fat improves the acceptability of samples. Based on the overall parameters analyzed, DLSSF containing 60% water can be used to produce low‐fat beef patty by replacing fat at 100%. From these results, hydrated DLSSF could be an effective method to solve the problems of noncommunicable diseases related to animal fat consumption.
Analytical Solutions for Circular Elastic Membranes Under Pressure
Authors: Dai Zhaohe
Published: May 2024

This study investigates the problem of a circular elastic membrane clamped or adhered at its boundary and subjected to uniform transverse pressure. Many analytical solutions for this classical problem have been developed previously, using either a series-based approach (notably accurate but lengthy and implicit) or approximate kinematics (relatively simple yet lacking accuracy). Here, we seek new analytical solutions using a perturbed spherical cap to represent the shape of the pressurized membrane. Our approach yields simple, explicit solutions of remarkable accuracy for the deformed profile, pressure–deflection relation, strain distributions, and energy release rate, which are directly applicable to emerging ultrathin membrane systems.
SETDB1 modulates the TGFβ response in Duchenne muscular dystrophy myotubes
Authors: Granados Alice , Zamperoni Maeva , Rapone Roberta , Moulin Maryline , Boyarchuk Ekaterina , Bouyioukos Costas , Del Maestro Laurence , Joliot Véronique , Negroni Elisa , Mohamed Myriame , Piquet Sandra , Bigot Anne , Le Grand Fabien , Albini Sonia , Ait-Si-Ali Slimane
Published: May 2024

Overactivation of the transforming growth factor-β (TGFβ) signaling in Duchenne muscular dystrophy (DMD) is a major hallmark of disease progression, leading to fibrosis and muscle dysfunction. Here, we investigated the role of SETDB1 (SET domain, bifurcated 1), a histone lysine methyltransferase involved in muscle differentiation. Our data show that, following TGFβ induction, SETDB1 accumulates in the nuclei of healthy myotubes while being already present in the nuclei of DMD myotubes where TGFβ signaling is constitutively activated. Transcriptomics revealed that depletion of SETDB1 in DMD myotubes leads to down-regulation of TGFβ target genes coding for secreted factors involved in extracellular matrix remodeling and inflammation. Consequently, SETDB1 silencing in DMD myotubes abrogates the deleterious effect of their secretome on myoblast differentiation by impairing myoblast pro-fibrotic response. Our findings indicate that SETDB1 potentiates the TGFβ–driven fibrotic response in DMD muscles, providing an additional axis for therapeutic intervention.
Exchange of subtelomeric regions between chromosomes 4q and 10q reverts the FSHD genotype and phenotype
Authors: Ma Yinxing , Schwager (Karpukhina) Anna , Dib Carla , Gautier Candice , Hermine Olivier , Allemand Eric , Vassetzky Yegor S.
Published: May 2024

The most common form of facioscapulohumeral dystrophy (FSHD1) is caused by a partial loss of the D4Z4 macrosatellite repeat array in the subtelomeric region of chromosome 4. Patients with FSHD1 typically carry 1 to 10 D4Z4 repeats, whereas nonaffected individuals have 11 to 150 repeats. The ~150-kilobyte subtelomeric region of the chromosome 10q exhibits a ~99% sequence identity to the 4q, including the D4Z4 array. Nevertheless, contractions of the chr10 array do not cause FSHD or any known disease, as in most people D4Z4 array on chr10 is flanked by the nonfunctional polyadenylation signal, not permitting the DUX4 expression. Here, we attempted to correct the FSHD genotype by a CRISPR-Cas9–induced exchange of the chr4 and chr10 subtelomeric regions. We demonstrated that the induced t(4;10) translocation can generate recombinant genotypes translated into improved FSHD phenotype. FSHD myoblasts with the t(4;10) exhibited reduced expression of the DUX4 targets, restored PAX7 target expression, reduced sensitivity to oxidative stress, and improved differentiation capacity.
An Elderly Case of Minimal Change Nephrotic Syndrome: Correlation between Renal Tubular Dysfunction and the Onset of Oliguric Acute Kidney Injury Requiring Hemodialysis
Authors: Gojo Maika , Morimoto Chikayuki , Taira Syuntaro , Yasukawa Minoru , Asakawa Shinichiro , Nagura Michito , Arai Shigeyuki , Yamazaki Osamu , Tamura Yoshifuru , Shibata Shigeru , Fujigaki Yoshihide
Published: May 2024

Several theories have been proposed to explain the development of severe acute kidney injury (AKI) in patients with minimal change nephrotic syndrome (MCNS), but the exact mechanism remains unclear. We encountered an elderly patient with biopsy-proven MCNS who suffered from oliguric AKI, which required hemodialysis at the onset and during the first relapse of nephrotic syndrome. Throughout her relapse, we were able to monitor tubular injury markers, namely, urinary N-acetyl-β-D-glucosaminidase and urinary alpha-1-microglobulin levels. This patient had hypertension. 8.5 years after achieving complete remission, she experienced a relapse of nephrotic syndrome accompanied by AKI, necessitating hemodialysis. The hemodialysis was discontinued after 7 weeks of corticosteroid therapy and cyclosporin A treatment. During this relapse, we observed a correlation between the sudden increase in renal tubular injury markers and proteinuria levels and the progression of severe AKI. Conversely, a reduction in renal tubular injury markers and proteinuria was associated with the resolution of AKI. The abrupt elevation of both tubular injury markers and proteinuria levels suggests a possible breakdown in protein endocytosis in proximal tubular cells. Moreover, it is less likely that the acute reduction in intra-glomerular pressure is the primary cause of tubular injury, as it might result in a decrease in both glomerular filtration rate and proteinuria levels. It is conceivable that massive proteinuria, in conjunction with the patient’s clinical characteristics, may contribute to tubular injury, ultimately leading to severe AKI in this patient.
Impact of Dyslipidemia on Tear Film and Meibomian Gland Dysfunction: A Cross-Sectional Study of the Interplay between Serum Lipid Profile and Ocular Surface Health
Authors: Serrano-Morales José-Manuel , Álvarez-Santaliestra Noelia , Sánchez-González María Carmen , Ballesteros-Sánchez Antonio , Sánchez-González José-María
Published: May 2024

Purpose. To determine the relationship between dyslipidemia and dry eye disease (DED), as well as its influence on tear film and meibomian glands. Methods. This cross-sectional study included 40 patients with a mean age of 35.2 ± 13.9 years without any history of dyslipidemia. DED and serum lipid profile were evaluated after 8 hours of fasting. Patients were classified according to serum lipid levels with the following cut-off values: total cholesterol (TC) (200 mg/dl), high-density lipoprotein (HDL) (40 mg/dl), low-density lipoprotein (LDL) (130 mg/dl), and triglycerides (TG) (150 mg/dl). The relationship between serum lipid levels and DED was analyzed with the following variables: dry eye questionnaire-5 (DEQ-5), first (F-NIBUT) and average (A-NIBUT) noninvasive breakup time, tear meniscus height (TMH), lipid layer grade (LLG), conjunctival bulbar redness (CBR), and upper (U-LAMG) and lower (L-LAMG) loss area of meibomian glands. Results. Regarding tear film, patients with elevated TC and LDL levels reported significantly higher DEQ-5 scores and TMH (P<0.05), while those with lower HDL levels showed significantly higher LLG (p<0.05). Regarding MGD, patients with elevated TC, LDL, and TG, as well as lower HDL levels showed significantly higher L-LAMG (p<0.05). HDL was correlated with LLG (p<0.05), while TC was correlated with TMH (p<0.05) and L-LAMG (p<0.05), respectively. Conclusions. Disorders in TC, HDL, LDL, and TG levels were associated with DED, having an impact on the tear film and meibomian glands, specifically in DEQ-5 scores, LLG, and L-LAMG.
Supplementary Figure S5 from Serum Lipidome Profiling Reveals a Distinct Signature of Ovarian Cancer in Korean Women
Authors: Sah Samyukta , Bifarin Olatomiwa O. , Moore Samuel G. , Gaul David A. , Chung Hyewon , Kwon Sun Young , Cho Hanbyoul , Cho Chi-Heum , Kim Jae-Hoon , Kim Jaeyeon , Fernández Facundo M.
Published: May 2024

Supplementary Figure S5 shows Serum lipidome analysis of high-grade serous carcinoma (HGSC) vs. other OC subtypes.
Supplementary Figure S3 from Serum Lipidome Profiling Reveals a Distinct Signature of Ovarian Cancer in Korean Women
Authors: Sah Samyukta , Bifarin Olatomiwa O. , Moore Samuel G. , Gaul David A. , Chung Hyewon , Kwon Sun Young , Cho Hanbyoul , Cho Chi-Heum , Kim Jae-Hoon , Kim Jaeyeon , Fernández Facundo M.
Published: May 2024

Supplementary Figure S3 shows Principal Component Analysis for ovarian cancer (OC) serum samples using annotated lipid features as the input.
Supplementary Figure 1 from Diffsig: Associating Risk Factors with Mutational Signatures
Authors: Park Ji-Eun , Smith Markia A. , Van Alsten Sarah C. , Walens Andrea , Wu Di , Hoadley Katherine A. , Troester Melissa A. , Love Michael I.
Published: May 2024

This figure shows the hierarchical model and additional details of Diffsig model
Supplementary Table S5 from Molecular and Pathologic Characterization of YAP1-Expressing Small Cell Lung Cancer Cell Lines Leads to Reclassification as SMARCA4-Deficient Malignancies
Authors: Ng Jin , Cai Ling , Girard Luc , Prall Owen W.J. , Rajan Neeha , Khoo Christine , Batrouney Ahida , Byrne David J. , Boyd Danielle K. , Kersbergen Ariena J. , Christie Michael , Minna John D. , Burr Marian L. , Sutherland Kate D.
Published: May 2024

CCLE cell lines used in Figure 4 and Supplementary Figure S6A.
Supplementary Figure S8 from Selective CDK7 Inhibition Suppresses Cell Cycle Progression and MYC Signaling While Enhancing Apoptosis in Therapy-resistant Estrogen Receptor–positive Breast Cancer
Authors: Guarducci Cristina , Nardone Agostina , Russo Douglas , Nagy Zsuzsanna , Heraud Capucine , Grinshpun Albert , Zhang Qi , Freelander Allegra , Leventhal Mathew Joseph , Feit Avery , Cohen Feit Gabriella , Feiglin Ariel , Liu Weihan , Hermida-Prado Francisco , Kesten Nikolas , Ma Wen , De Angelis Carmine , Morlando Antonio , O'Donnell Madison , Naumenko Sergey , Huang Shixia , Nguyen Quang-Dé , Huang Ying , Malorni Luca , Bergholz Johann S. , Zhao Jean J. , Fraenkel Ernest , Lim Elgene , Schiff Rachel , Shapiro Geoffrey I. , Jeselsohn Rinath
Published: May 2024

PalboS and PalboR T47D and MCF7 trancrisptomic and proteomic profile after treatment with SY-1365.
Supplementary Figure S3 from Selective CDK7 Inhibition Suppresses Cell Cycle Progression and MYC Signaling While Enhancing Apoptosis in Therapy-resistant Estrogen Receptor–positive Breast Cancer
Authors: Guarducci Cristina , Nardone Agostina , Russo Douglas , Nagy Zsuzsanna , Heraud Capucine , Grinshpun Albert , Zhang Qi , Freelander Allegra , Leventhal Mathew Joseph , Feit Avery , Cohen Feit Gabriella , Feiglin Ariel , Liu Weihan , Hermida-Prado Francisco , Kesten Nikolas , Ma Wen , De Angelis Carmine , Morlando Antonio , O'Donnell Madison , Naumenko Sergey , Huang Shixia , Nguyen Quang-Dé , Huang Ying , Malorni Luca , Bergholz Johann S. , Zhao Jean J. , Fraenkel Ernest , Lim Elgene , Schiff Rachel , Shapiro Geoffrey I. , Jeselsohn Rinath
Published: May 2024

MYC transcription is impaired by CDK7 inhibition.
Figure 4 from Molecular and Pathologic Characterization of YAP1-Expressing Small Cell Lung Cancer Cell Lines Leads to Reclassification as SMARCA4-Deficient Malignancies
Authors: Ng Jin , Cai Ling , Girard Luc , Prall Owen W.J. , Rajan Neeha , Khoo Christine , Batrouney Ahida , Byrne David J. , Boyd Danielle K. , Kersbergen Ariena J. , Christie Michael , Minna John D. , Burr Marian L. , Sutherland Kate D.
Published: May 2024

SCLC-Y cell lines with SMARCA4 loss share a similar transcriptome to SMARCA4-UT. A, Unsupervised hierarchical clustering, based on differentially expressed genes in primary SMARCA4-UT compared with primary SMARCA4-mutant NSCLC identified by Le Loarer and colleagues (24; n = 758 genes), was performed on SCCOHT and lung carcinoma samples [cell lines from the CCLE and bulk-RNA sequenced patient samples from Le Loarer and colleagues (24)]. Inset: SMARCA4-UT cluster from A with cell line and sample annotation. B, mRNA expression of SMARCA4, SMARCA2, and CLDN4 (claudin-4) in cell lines of the SMARCA4-UT cluster, SMARCA4 mutant NSCLC, SMARCA4 proficient NSCLC, and SCLC-A, -N, -P (Supplementary Table S5). Kruskal–Wallis test with a Dunn multiple comparison test; *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001; ns, P ≥ 0.05. C, IHC of SMARCA2 and claudin-4 in SMARCA4-WT and SMARCA4-mutant cell line xenografts. Scale bar = 100 μm.
Supplementary Table S4 from Systemic Biological Mechanisms of Neurocognitive Dysfunction in Long-Term Survivors of Childhood Hodgkin Lymphoma
Authors: Williams AnnaLynn M. , Liu Wei , Ehrhardt Matthew J. , Mirzaei Salehabadi Sedigheh , Panoskaltsis-Mortari Angela , Phillips Nicholas S. , Mulrooney Daniel A. , Flerlage Jamie E. , Yasui Yutaka , Srivastava Deokumar , Robison Leslie L. , Hudson Melissa M. , Ness Kirsten K. , Sabin Noah D. , Krull Kevin R.
Published: May 2024

Full mediation analyses1 completed among survivors of Hodgkin lymphoma (findings of borderline significance [p<0.10] are bolded).
Supplementary Figure S3 from Radiotherapy Enhances Metastasis Through Immune Suppression by Inducing PD-L1 and MDSC in Distal Sites
Authors: Hou Yuzhu , Yang Kaiting , Wang Liangliang , Wang Jiaai , Huang Xiaona , Piffkó András , Luo Sean Z. , Yu Xinshuang , Rao Enyu , Martinez Carlos , Bugno Jason , Mack Matthias , Vokes Everett E. , Pitroda Sean P. , Chmura Steven J. , Weichselbaum Ralph R. , Liang Hua Laura
Published: May 2024

Supplementary figure 3. Gating strategy and PD-L1 in subsets of patient PBMCs
Supplementary Figure S1 from Radiotherapy Enhances Metastasis Through Immune Suppression by Inducing PD-L1 and MDSC in Distal Sites
Authors: Hou Yuzhu , Yang Kaiting , Wang Liangliang , Wang Jiaai , Huang Xiaona , Piffkó András , Luo Sean Z. , Yu Xinshuang , Rao Enyu , Martinez Carlos , Bugno Jason , Mack Matthias , Vokes Everett E. , Pitroda Sean P. , Chmura Steven J. , Weichselbaum Ralph R. , Liang Hua Laura
Published: May 2024

Supplementary figure 1. Radiation is not able to induce an abscopal effect. A. Growth of LLC
flank local tumors received local RT. B. Flow cytometry result of whole lung gated on CD45-
CD31- population. C. q-PCR result indicating expression of genes in sorted CD45-
CD31- lung
cells (Mets), with LLC and MC38 cell lines as controls. The relative expression is presented as
fold over those of LLC. D. Quantification of lung metastasis of LLC tumors in the MC38/LLC
tumor model by percentage of tumor area. E. Growth of heterogeneous 2-tumor model
(MC38/B16F10) in which MC38 received ctrl (sham treatment) or IR. F. Growth curve of the
local KPC tumors treated with control and 20 Gy. G. Distal LLC tumors growth curve. H.
Number of LLC lung mets in control and irradiated mice in KPC/LLC model. I. Percentage of
metastasis area of total lung. J. Representative lung sections of the mice treated with control or
IR. Statistics by ANOVA (A, E, F, G) and t-test assuming unequal variance (B, D, H, G). A and
E, N=5. Experiments were repeated 3 times. F-I, N=6-7
Supplementary Figure S4 from Platinum-Based Chemotherapy Attenuates the Effector Response of CD8 T Cells to Concomitant PD-1 Blockade
Authors: Mariniello Annapaola , Nasti Tahseen H. , Chang Daniel Y. , Hashimoto Masao , Malik Sakshi , McManus Daniel T. , Lee Judong , McGuire Donald J. , Cardenas Maria A. , Umana Pablo , Nicolini Valeria , Antia Rustom , Saha Ananya , Buchwald Zachary , Kissick Hayden , Ghorani Ehsan , Novello Silvia , Sangiolo Dario , Scagliotti Giorgio V. , Ramalingam Suresh S. , Ahmed Rafi
Published: May 2024

A) Number of total lymphocytes and of CD8+ T cells in the spleen of mice treated with either concomitant or sequential combination of CT and aPD-L1. (B) Representative FACS plots showing the frequency of stem-like (PD-1+TCF-1+TIM-3-), effector transitory (PD-1+CX3CR1+TIM-3+) and terminally differentiated (PD-1+CD101+TIM-3+) Gp33+ CD8 T cells in the spleen across the treatment groups, with quantified numbers shown in (C). Data are pooled from 2 independent experiments of 4-6 mice per group. For statistical analysis the T-test was used, total numbers were Log10 transformed. Bars represent mean and SEM. * p<0.05; ** p<0.01; **** p<0.0001.
Supplementary Table 2 from Optimizing Cervical Target Volume in Patients with Nasopharyngeal Cancer Based On Nodal Drainage Distance
Authors: Liu Yang , Yan Wenbin , Hu Chaosu , Huang Xiaodong , Wang Kai , Qu Yuan , Chen Xuesong , Wu Runye , Zhang Ye , Zhang Jianghu , Luo Jingwei , Li Yexiong , Wang Jingbo , Yi Junlin
Published: May 2024

Representativeness of Study Participants.
Supplementary Table 1 from Optimizing Cervical Target Volume in Patients with Nasopharyngeal Cancer Based On Nodal Drainage Distance
Authors: Liu Yang , Yan Wenbin , Hu Chaosu , Huang Xiaodong , Wang Kai , Qu Yuan , Chen Xuesong , Wu Runye , Zhang Ye , Zhang Jianghu , Luo Jingwei , Li Yexiong , Wang Jingbo , Yi Junlin
Published: May 2024

Euclidean and vertical distances in per-LN level and per-patient level for all distribution patterns of metastatic LNs.
Supplementary Table S5 from Improved Risk-Stratification Scheme for Mismatch-Repair Proficient Stage II Colorectal Cancers Using the Digital Pathology Biomarker QuantCRC
Authors: Wu Christina , Pai Reetesh K. , Kosiorek Heidi , Banerjee Imon , Pfeiffer Ashlyn , Hagen Catherine E. , Hartley Christopher P. , Graham Rondell P. , Sonbol Mohamad B. , Bekaii-Saab Tanios , Xie Hao , Sinicrope Frank A. , Patel Bhavik , Westerling-Bui Thomas , Shivji Sameer , Conner James , Swallow Carol , Savage Paul , Cyr David P. , Kirsch Richard , Pai Rish K.
Published: May 2024

Supplementary Table S5. Adjuvant chemotherapy according to ASCO and QuantCRC-Integrated risk groups.
Supplementary Table S2 from Improved Innate Immune Function in Patients with Chronic Lymphocytic Leukemia Treated with Targeted Therapy in Clinical Trials
Authors: Svanberg Teglgaard Rebecca , Marquart Hanne Vibeke , Hartling Hans Jakob , Bay Jakob Thaning , da Cunha-Bang Caspar , Brieghel Christian , Faitová Tereza , Enggaard Lisbeth , Kater Arnon P. , Levin Mark-David , Kersting Sabina , Ostrowski Sisse Rye , Niemann Carsten U.
Published: May 2024

Supplementary Table S2. Gating strategies for the immune cell subset populations included in this study.
Supplementary Video S4 from Mesothelin CAR T Cells Secreting Anti-FAP/Anti-CD3 Molecules Efficiently Target Pancreatic Adenocarcinoma and its Stroma
Authors: Wehrli Marc , Guinn Samantha , Birocchi Filippo , Kuo Adam , Sun Yi , Larson Rebecca C. , Almazan Antonio J. , Scarfò Irene , Bouffard Amanda A. , Bailey Stefanie R. , Anekal Praju Vikas , Montero Llopis Paula , Nieman Linda T. , Song Yuhui , Xu Katherine H. , Berger Trisha R. , Kann Michael C. , Leick Mark B. , Silva Harrison , Salas-Benito Diego , Kienka Tamina , Grauwet Korneel , Armstrong Todd D. , Zhang Rui , Zhu Qingfeng , Fu Juan , Schmidts Andrea , Korell Felix , Jan Max , Choi Bryan D. , Liss Andrew S. , Boland Genevieve M. , Ting David T. , Burkhart Richard A. , Jenkins Russell W. , Zheng Lei , Jaffee Elizabeth M. , Zimmerman Jacquelyn W. , Maus Marcela V.
Published: May 2024

Supplementary Video S4. Meso^FAP CAR T cells not on target
Supplementary Video S11 from Mesothelin CAR T Cells Secreting Anti-FAP/Anti-CD3 Molecules Efficiently Target Pancreatic Adenocarcinoma and its Stroma
Authors: Wehrli Marc , Guinn Samantha , Birocchi Filippo , Kuo Adam , Sun Yi , Larson Rebecca C. , Almazan Antonio J. , Scarfò Irene , Bouffard Amanda A. , Bailey Stefanie R. , Anekal Praju Vikas , Montero Llopis Paula , Nieman Linda T. , Song Yuhui , Xu Katherine H. , Berger Trisha R. , Kann Michael C. , Leick Mark B. , Silva Harrison , Salas-Benito Diego , Kienka Tamina , Grauwet Korneel , Armstrong Todd D. , Zhang Rui , Zhu Qingfeng , Fu Juan , Schmidts Andrea , Korell Felix , Jan Max , Choi Bryan D. , Liss Andrew S. , Boland Genevieve M. , Ting David T. , Burkhart Richard A. , Jenkins Russell W. , Zheng Lei , Jaffee Elizabeth M. , Zimmerman Jacquelyn W. , Maus Marcela V.
Published: May 2024

Supplementary Video S11. UTD T cells on CAF
Supplementary Table S2 from FDG PET/CT Imaging 1 Week after a Single Dose of Pembrolizumab Predicts Treatment Response in Patients with Advanced Melanoma
Authors: Anderson Thomas M. , Chang Bryan H. , Huang Alexander C. , Xu Xiaowei , Yoon Daniel , Shang Catherine G. , Mick Rosemarie , Schubert Erin , McGettigan Suzanne , Kreider Kristin , Xu Wei , Wherry E. John , Schuchter Lynn M. , Amaravadi Ravi K. , Mitchell Tara C. , Farwell Michael D.
Published: May 2024

Supplementary Table S2. Representativeness of Study Participants.
Supplementary Figure S6 from Mesothelin CAR T Cells Secreting Anti-FAP/Anti-CD3 Molecules Efficiently Target Pancreatic Adenocarcinoma and its Stroma
Authors: Wehrli Marc , Guinn Samantha , Birocchi Filippo , Kuo Adam , Sun Yi , Larson Rebecca C. , Almazan Antonio J. , Scarfò Irene , Bouffard Amanda A. , Bailey Stefanie R. , Anekal Praju Vikas , Montero Llopis Paula , Nieman Linda T. , Song Yuhui , Xu Katherine H. , Berger Trisha R. , Kann Michael C. , Leick Mark B. , Silva Harrison , Salas-Benito Diego , Kienka Tamina , Grauwet Korneel , Armstrong Todd D. , Zhang Rui , Zhu Qingfeng , Fu Juan , Schmidts Andrea , Korell Felix , Jan Max , Choi Bryan D. , Liss Andrew S. , Boland Genevieve M. , Ting David T. , Burkhart Richard A. , Jenkins Russell W. , Zheng Lei , Jaffee Elizabeth M. , Zimmerman Jacquelyn W. , Maus Marcela V.
Published: May 2024

Supplementary Figure S6. Human CAF-1 cells do not expand in vivo in NSG mice in the presence or absence of AsPC-1 or PDX1294 cells.
Supplementary Figure S1 from Mesothelin CAR T Cells Secreting Anti-FAP/Anti-CD3 Molecules Efficiently Target Pancreatic Adenocarcinoma and its Stroma
Authors: Wehrli Marc , Guinn Samantha , Birocchi Filippo , Kuo Adam , Sun Yi , Larson Rebecca C. , Almazan Antonio J. , Scarfò Irene , Bouffard Amanda A. , Bailey Stefanie R. , Anekal Praju Vikas , Montero Llopis Paula , Nieman Linda T. , Song Yuhui , Xu Katherine H. , Berger Trisha R. , Kann Michael C. , Leick Mark B. , Silva Harrison , Salas-Benito Diego , Kienka Tamina , Grauwet Korneel , Armstrong Todd D. , Zhang Rui , Zhu Qingfeng , Fu Juan , Schmidts Andrea , Korell Felix , Jan Max , Choi Bryan D. , Liss Andrew S. , Boland Genevieve M. , Ting David T. , Burkhart Richard A. , Jenkins Russell W. , Zheng Lei , Jaffee Elizabeth M. , Zimmerman Jacquelyn W. , Maus Marcela V.
Published: May 2024

Supplementary Figure S1. Characterization of mesoFAP CAR T-cells compared to control CAR T-cells.
Data from Selective CDK7 Inhibition Suppresses Cell Cycle Progression and MYC Signaling While Enhancing Apoptosis in Therapy-resistant Estrogen Receptor–positive Breast Cancer
Authors: Guarducci Cristina , Nardone Agostina , Russo Douglas , Nagy Zsuzsanna , Heraud Capucine , Grinshpun Albert , Zhang Qi , Freelander Allegra , Leventhal Mathew Joseph , Feit Avery , Cohen Feit Gabriella , Feiglin Ariel , Liu Weihan , Hermida-Prado Francisco , Kesten Nikolas , Ma Wen , De Angelis Carmine , Morlando Antonio , O'Donnell Madison , Naumenko Sergey , Huang Shixia , Nguyen Quang-Dé , Huang Ying , Malorni Luca , Bergholz Johann S. , Zhao Jean J. , Fraenkel Ernest , Lim Elgene , Schiff Rachel , Shapiro Geoffrey I. , Jeselsohn Rinath
Published: May 2024

AbstractPurpose:
Resistance to endocrine therapy (ET) and CDK4/6 inhibitors (CDK4/6i) is a clinical challenge in estrogen receptor (ER)-positive (ER+) breast cancer. Cyclin-dependent kinase 7 (CDK7) is a candidate target in endocrine-resistant ER+ breast cancer models and selective CDK7 inhibitors (CDK7i) are in clinical development for the treatment of ER+ breast cancer. Nonetheless, the precise mechanisms responsible for the activity of CDK7i in ER+ breast cancer remain elusive. Herein, we sought to unravel these mechanisms.
Experimental Design:
We conducted multi-omic analyses in ER+ breast cancer models in vitro and in vivo, including models with different genetic backgrounds. We also performed genome-wide CRISPR/Cas9 knockout screens to identify potential therapeutic vulnerabilities in CDK4/6i-resistant models.
Results:
We found that the on-target antitumor effects of CDK7 inhibition in ER+ breast cancer are in part p53 dependent, and involve cell cycle inhibition and suppression of c-Myc. Moreover, CDK7 inhibition exhibited cytotoxic effects, distinctive from the cytostatic nature of ET and CDK4/6i. CDK7 inhibition resulted in suppression of ER phosphorylation at S118; however, long-term CDK7 inhibition resulted in increased ER signaling, supporting the combination of ET with a CDK7i. Finally, genome-wide CRISPR/Cas9 knockout screens identified CDK7 and MYC signaling as putative vulnerabilities in CDK4/6i resistance, and CDK7 inhibition effectively inhibited CDK4/6i-resistant models.
Conclusions:
Taken together, these findings support the clinical investigation of selective CDK7 inhibition combined with ET to overcome treatment resistance in ER+ breast cancer. In addition, our study highlights the potential of increased c-Myc activity and intact p53 as predictors of sensitivity to CDK7i-based treatments.
Data from Radiotherapy Enhances Metastasis Through Immune Suppression by Inducing PD-L1 and MDSC in Distal Sites
Authors: Hou Yuzhu , Yang Kaiting , Wang Liangliang , Wang Jiaai , Huang Xiaona , Piffkó András , Luo Sean Z. , Yu Xinshuang , Rao Enyu , Martinez Carlos , Bugno Jason , Mack Matthias , Vokes Everett E. , Pitroda Sean P. , Chmura Steven J. , Weichselbaum Ralph R. , Liang Hua Laura
Published: May 2024

AbstractPurpose:
Radiotherapy (RT) is a widely employed anticancer treatment. Emerging evidence suggests that RT can elicit both tumor-inhibiting and tumor-promoting immune effects. The purpose of this study is to investigate immune suppressive factors of radiotherapy.
Experimental Design:
We used a heterologous two-tumor model in which adaptive concomitant immunity was eliminated.
Results:
Through analysis of PD-L1 expression and myeloid-derived suppressor cells (MDSC) frequencies using patient peripheral blood mononuclear cells and murine two-tumor and metastasis models, we report that local irradiation can induce a systemic increase in MDSC, as well as PD-L1 expression on dendritic cells and myeloid cells, and thereby increase the potential for metastatic dissemination in distal, nonirradiated tissue. In a mouse model using two distinct tumors, we found that PD-L1 induction by ionizing radiation was dependent on elevated chemokine CXCL10 signaling. Inhibiting PD-L1 or MDSC can potentially abrogate RT-induced metastasis and improve clinical outcomes for patients receiving RT.
Conclusions:
Blockade of PD-L1/CXCL10 axis or MDSC infiltration during irradiation can enhance abscopal tumor control and reduce metastasis.
Data from Improvements in Posttransplant Outcomes Over Two Decades in Older Patients with Acute Myeloid Leukemia in the EBMT ALWP Study
Authors: Bazarbachi Ali , Labopin Myriam , Moukalled Nour , Kröger Nicolaus , Rautenberg Christina , Schetelig Johannes , Finke Jürgen , Blau Igor Wolfgang , Blaise Didier , Stelljes Matthias , Eder Matthias , Platzbecker Uwe , Dreger Peter , Bethge Wolfgang , Tischer Johanna , Burns David , Sengeloev Henrik , Brissot Eolia , Giebel Sebastian , Nagler Arnon , Ciceri Fabio , Mohty Mohamad
Published: May 2024

AbstractPurpose:
Acute myeloid leukemia (AML) is a disease of older patients. Progress in allogeneic hematopoietic cell transplantation (allo-HCT) allowed the delivery of allo-HCT to older patients. We assessed changes over time in transplant characteristics and outcomes in patients with AML ages 65 years and above.
Patients and Methods:
We identified 7,215 patients with AML (median age 68 years, range 65–80) allografted between 2000 and 2021 in first complete remission (CR1; 64%), second or subsequent remission (CR2+; 14%), or active disease (22%).
Results:
Median follow-up was 40 months. The 3-year cumulative relapse incidence (RI) gradually and significantly decreased from 37% to 31%, then to 30% (P = 0.001) over the three time periods (2000–2009; 2010–2014; 2015–2021), whereas nonrelapse mortality (NRM) decreased from 31% and 31% to 27% (P = 0.003). The 3-year leukemia-free survival (LFS) and overall survival (OS) gradually and significantly improved from 32% to 38%, and then to 44% (P = 0.001) and from 37% to 42%, and then to 49% (P = 0.001), respectively. In multivariate analysis, significant improvement in the RI, LFS, and OS were noted after 2015, whereas NRM was not significantly affected. This improvement was observed regardless of disease status at transplant.
Conclusions:
In older patients with AML, we observed an impressive improvement over time in posttransplant outcomes, mostly attributed to decreased RI rather than decreased NRM, and regardless of disease status at transplant. These large-scale, real-world data can serve as a benchmark for future studies in this setting and indicate that the opportunity for transplant for the elderly should be mandatory and no longer an option.
Supplementary Table S4 from Jak2V617F Reversible Activation Shows Its Essential Requirement in Myeloproliferative Neoplasms
Authors: Dunbar Andrew J. , Bowman Robert L. , Park Young C. , O'Connor Kavi , Izzo Franco , Myers Robert M. , Karzai Abdul , Zaroogian Zachary , Kim Won Jun , Fernández-Maestre Inés , Waarts Michael R. , Nazir Abbas , Xiao Wenbin , Codilupi Tamara , Brodsky Max , Farina Mirko , Cai Louise , Cai Sheng F. , Wang Benjamin , An Wenbin , Yang Julie L. , Mowla Shoron , Eisman Shira E. , Hanasoge Somasundara Amritha Varshini , Glass Jacob L. , Mishra Tanmay , Houston Remie , Guzzardi Emily , Martinez Benitez Anthony R. , Viny Aaron D. , Koche Richard P. , Meyer Sara C. , Landau Dan A. , Levine Ross L.
Published: May 2024

Patient characteristics for scATAC-Seq
Figure S4 from Early Immune Remodeling Steers Clinical Response to First-Line Chemoimmunotherapy in Advanced Gastric Cancer
Authors: An Minae , Mehta Arnav , Min Byung Hoon , Heo You Jeong , Wright Samuel J. , Parikh Milan , Bi Lynn , Lee Hyuk , Kim Tae Jun , Lee Song-Yi , Moon Jeonghyeon , Park Ryan J. , Strickland Matthew R. , Park Woong-Yang , Kang Won Ki , Kim Kyoung-Mee , Kim Seung Tae , Klempner Samuel J. , Lee Jeeyun
Published: May 2024

Figure S4. Multiplexed immunofluorescence (mIF) images of BL and FU1
samples from two patients, E17 (slow progressor) and E35 (fast progressor),
staining for (A) panCK, PD-L1, CD163, CD68, CD14 and CD8, and (B) panCK,
PD-L1, CD4, CD8 and Granzyme B.
Figure S26 from Early Immune Remodeling Steers Clinical Response to First-Line Chemoimmunotherapy in Advanced Gastric Cancer
Authors: An Minae , Mehta Arnav , Min Byung Hoon , Heo You Jeong , Wright Samuel J. , Parikh Milan , Bi Lynn , Lee Hyuk , Kim Tae Jun , Lee Song-Yi , Moon Jeonghyeon , Park Ryan J. , Strickland Matthew R. , Park Woong-Yang , Kang Won Ki , Kim Kyoung-Mee , Kim Seung Tae , Klempner Samuel J. , Lee Jeeyun
Published: May 2024

Figure S26. (A) Proportion of CD8 T cells in non-responder and responder
patients split by timepoint. Statistical comparisons performed using a Wilcoxon
signed-rank test. (B) Multiplexed immunofluorescence (mIF) images of BL, FU1
and FU2 samples from two patients, E40 (slow progressor) and E41 (fast
progressor), staining for panCK, PD-L1, CD4, CD8 and Granzyme B. (C)
Proportion of CD8 T cells macrophages, obtained from mIF images, at BL, FU1
and FU2 in non-responder and responder patients. Statistical comparison
performed using a Wilcoxon signed-rank test. (D) Proportion of naive, memory,
effector and exhausted CD8 T cell subsets in non-responder and responder
patients split by timepoint. Statistical comparisons performed using a Wilcoxon
signed-rank test. (E) Proportion of regulatory T cell and Th1 CD4 T cell subsets in
fast v.s. slow progressor patients split by timepoint. Statistical comparisons
performed using a Wilcoxon signed-rank test. (F) Expression of CXCL13 in CD4
T cells in fast v.s. slow progressor patients split by timepoint. Statistical
comparisons performed using a Wilcoxon signed-rank test.
Figure S10 from Early Immune Remodeling Steers Clinical Response to First-Line Chemoimmunotherapy in Advanced Gastric Cancer
Authors: An Minae , Mehta Arnav , Min Byung Hoon , Heo You Jeong , Wright Samuel J. , Parikh Milan , Bi Lynn , Lee Hyuk , Kim Tae Jun , Lee Song-Yi , Moon Jeonghyeon , Park Ryan J. , Strickland Matthew R. , Park Woong-Yang , Kang Won Ki , Kim Kyoung-Mee , Kim Seung Tae , Klempner Samuel J. , Lee Jeeyun
Published: May 2024

Figure S10. Mean usage of epithelial cNMF programs per sample at (A) baseline,
(B) post-chemotherapy (FU1) and (C) post-immunotherapy (FU2).
Supplementary Table S7 from Pan-Cancer Comparative and Integrative Analyses of Driver Alterations Using Japanese and International Genomic Databases
Authors: Horie Sara , Saito Yuki , Kogure Yasunori , Mizuno Kota , Ito Yuta , Tabata Mariko , Kanai Takanori , Murakami Koichi , Koya Junji , Kataoka Keisuke
Published: May 2024

Frequency of mutated samples for 352 recurrent driver gene–cancer type combinations
Supplementary Figure S17 from Long-term Multimodal Recording Reveals Epigenetic Adaptation Routes in Dormant Breast Cancer Cells
Authors: Rosano Dalia , Sofyali Emre , Dhiman Heena , Ghirardi Chiara , Ivanoiu Diana , Heide Timon , Vingiani Andrea , Bertolotti Alessia , Pruneri Giancarlo , Canale Eleonora , Dewhurst Hannah F. , Saha Debjani , Slaven Neil , Barozzi Iros , Li Tong , Zemlyanskiy Grigory , Phillips Henry , James Chela , Győrffy Balázs , Lynn Claire , Cresswell George D. , Rehman Farah , Noberini Roberta , Bonaldi Tiziana , Sottoriva Andrea , Magnani Luca
Published: May 2024

TRADITIOM MCF7 Bulk RNA-seq
Supplementary Figure S12 from Long-term Multimodal Recording Reveals Epigenetic Adaptation Routes in Dormant Breast Cancer Cells
Authors: Rosano Dalia , Sofyali Emre , Dhiman Heena , Ghirardi Chiara , Ivanoiu Diana , Heide Timon , Vingiani Andrea , Bertolotti Alessia , Pruneri Giancarlo , Canale Eleonora , Dewhurst Hannah F. , Saha Debjani , Slaven Neil , Barozzi Iros , Li Tong , Zemlyanskiy Grigory , Phillips Henry , James Chela , Győrffy Balázs , Lynn Claire , Cresswell George D. , Rehman Farah , Noberini Roberta , Bonaldi Tiziana , Sottoriva Andrea , Magnani Luca
Published: May 2024

The de novo dormant persister pool is generated stochastically
Supplementary Table S5 from Cancer Mutations Converge on a Collection of Protein Assemblies to Predict Resistance to Replication Stress
Authors: Zhao Xiaoyu , Singhal Akshat , Park Sungjoon , Kong JungHo , Bachelder Robin , Ideker Trey
Published: May 2024

Table S5 Assembly predictive performance in cisplatin-treated cervical cancer.xlsx
Supplementary Table S4 from Cancer Mutations Converge on a Collection of Protein Assemblies to Predict Resistance to Replication Stress
Authors: Zhao Xiaoyu , Singhal Akshat , Park Sungjoon , Kong JungHo , Bachelder Robin , Ideker Trey
Published: May 2024

Table S4 Assembly enrichment in replication and drug sensitivity screens.xlsx
Supplementary Raw Data Tables from Acute Lymphoblastic Leukemia with Myeloid Mutations Is a High-Risk Disease Associated with Clonal Hematopoiesis
Authors: Saygin Caner , Zhang Pu , Stauber Jacob , Aldoss Ibrahim , Sperling Adam S. , Weeks Lachelle D. , Luskin Marlise R. , Knepper Todd C. , Wanjari Pankhuri , Wang Peng , Lager Angela M. , Fitzpatrick Carrie , Segal Jeremy P. , Gharghabi Mehdi , Gurbuxani Sandeep , Venkataraman Girish , Cheng Jason X. , Eisfelder Bart J. , Bohorquez Oliver , Patel Anand A. , Umesh Nagalakshmi Sheethal , Jayaram Savita , Odenike Olatoyosi M. , Larson Richard A. , Godley Lucy A. , Arber Daniel A. , Gibson Christopher J. , Munshi Nikhil C. , Marcucci Guido , Ebert Benjamin L. , Greally John M. , Steidl Ulrich , Lapalombella Rosa , Shah Bijal D. , Stock Wendy
Published: May 2024

Raw patient and scRNA-seq data
Supplementary Table 3 from Spatial Mapping of Hematopoietic Clones in Human Bone Marrow
Authors: Young Andrew L. , Davis Hannah C. , Cox Maggie J. , Parsons Tyler M. , Burkart Samantha C. , Bender Diane E. , Sun Lulu , Oh Stephen T. , Challen Grant A.
Published: May 2024

Supplementary Table 3. MissionBio Tapestri Myeloid Panel (top) targeting 45 genes with 312 amplicons over approximately 65kb of target space and the CITE-Seq (bottom) panel containing 42 primary antibodies for the Mission Bio Tapestri platform.
Table S2 from Acquired Multidrug Resistance in AML Is Caused by Low Apoptotic Priming in Relapsed Myeloblasts
Authors: Olesinski Elyse A. , Bhatia Karanpreet Singh , Wang Chuqi , Pioso Marissa S. , Lin Xiao Xian , Mamdouh Ahmed M. , Ng Shu Xuan , Sandhu Vedant , Jasdanwala Shaista Shabbir , Yilma Binyam , Bohl Stephan , Ryan Jeremy A. , Malani Disha , Luskin Marlise R. , Kallioniemi Olli , Porkka Kimmo , Adamia Sophia , Chng Wee Joo , Osato Motomi , Weinstock David M. , Garcia Jacqueline S. , Letai Anthony , Bhatt Shruti
Published: May 2024

Supplemental Table 2 shows sample IDs submitted for RNA-seq.
Figure S11 from Acquired Multidrug Resistance in AML Is Caused by Low Apoptotic Priming in Relapsed Myeloblasts
Authors: Olesinski Elyse A. , Bhatia Karanpreet Singh , Wang Chuqi , Pioso Marissa S. , Lin Xiao Xian , Mamdouh Ahmed M. , Ng Shu Xuan , Sandhu Vedant , Jasdanwala Shaista Shabbir , Yilma Binyam , Bohl Stephan , Ryan Jeremy A. , Malani Disha , Luskin Marlise R. , Kallioniemi Olli , Porkka Kimmo , Adamia Sophia , Chng Wee Joo , Osato Motomi , Weinstock David M. , Garcia Jacqueline S. , Letai Anthony , Bhatt Shruti
Published: May 2024

Supplemental Figure 11 shows comparison of leukemia-related genetic mutations in drug-resistant and parental AML PDX models.
Figure S1 from Acquired Multidrug Resistance in AML Is Caused by Low Apoptotic Priming in Relapsed Myeloblasts
Authors: Olesinski Elyse A. , Bhatia Karanpreet Singh , Wang Chuqi , Pioso Marissa S. , Lin Xiao Xian , Mamdouh Ahmed M. , Ng Shu Xuan , Sandhu Vedant , Jasdanwala Shaista Shabbir , Yilma Binyam , Bohl Stephan , Ryan Jeremy A. , Malani Disha , Luskin Marlise R. , Kallioniemi Olli , Porkka Kimmo , Adamia Sophia , Chng Wee Joo , Osato Motomi , Weinstock David M. , Garcia Jacqueline S. , Letai Anthony , Bhatt Shruti
Published: May 2024

Supplemental Figure 1 shows dynamic BH3 profiling of healthy human CD34+ cells.
Atrofias musculares
Authors: Levy José Antonio
Published: May 2024

De acordo com sua origem, o autor classifica as atrofias musculares em três grupos: as dependentes de lesão do sistema nervoso central, as secundáriasao comprometimento do neurônio motor periférico e as moléstias musculares primárias, ou miopatias. A seguir, são descritas as alterações encontradas nesses três tipos de amiotrofias, assim como as principais moléstias nas quais elas se verificam.
Rotura retroperitoneal do duodeno: apresentação de 11 casos
Authors: Psillakis Jorge Miguel , Mello Joamel Bruno de
Published: May 2024

Os autores apresentam 11 casos de rotura retroperitoneal de duodeno.Todos os pacientes em que não houve associação com lesão de outras vísceras, sobreviveram. A fístula duodenal apareceu como única complicação em 3 casos, obtendo-se a cura com tratamento clínico.