bluuebunny/crossref_metadata_2025 huggingface dataset:
La piscina: un nuevo contexto para la expresión oral y las emociones
Authors: Sánchez Morillas Carmen María , De la Torre Cobo José Miguel
Published: February 2020

Hoy en día innovar en el mundo de la educación infantil es una acción cada vez más compleja, porque parece que todo está inventado o que el hecho de innovar solo transcurre por las nuevas tecnologías. Deseamos mostrar un camino diferente: en el siguiente artículo pretendemos exponer y describir los principios básicos del desarrollo de una experiencia educativa que aúna elementos tan dispares como: la actividad acuática, la literatura infantil y el desarrollo de las emociones. En este sentido, se explica el proceso de acomodación de cómo los cuentos motores pueden convertirse en un instrumento educativo ideal para lograr el desarrollo de la expresión oral en los más pequeños. Asimismo, este nuevo escenario permite un espacio de comunicación de las emociones entre los padres, madres, tutores e infantes. Añadimos que la siguiente experiencia educativa se encuentra en una primera fase de experimentación y desarrollo, y persigue la paulatina creación y desarrollo de un itinerario de animación lectora.
La menstruación en la ficción infantil y juvenil: lo personal es político
Authors: Guichot Muñoz Elena , Díaz Gavira Inmaculada , De Sarlo Giulia
Published: February 2020

A pesar de la cotidianeidad del fenómeno fisiológico, la percepción propia y ajena sobre la menstruación se relaciona de forma internacional con una cuestión negativa, o como un tabú social. En este artículo se examina esta problemática desde una perspectiva de género, y se analizan recientes textos literario-artísticos dirigidos a público infantil y juvenil que tratan de romper con esta visión reduccionista y perjudicial para el reconocimiento de los procesos psico-emocionales femeninos. En esta literatura se usan claves como la conexión con la naturaleza, la sororidad, el humor o la multimodalidad para la reapropiación del poder femenino en el discurso socioemocional. Se concluye finalmente con un cuestionamiento sobre cómo llevar esta problemática al rango de política cultural, de la mano de las ficciones literarias.
Living Apart Together? The Organization of Political Parties beyond the Nation-State: The Flemish Case
Authors: Pittoors Gilles
Published: February 2020

This article aims to contribute both theoretically and empirically to the study of political parties in the EU context, focusing on party organisation. Theoretically, it draws on insights from various literatures to develop a novel typology of multilevel party organisation specific to the EU context. It argues that parties are goal-seeking actors that choose their organisation based on a cost-benefit analysis, involving both party characteristics and the institutional context. Empirically, the article applies this framework on the Flemish political parties. It finds that rational goal-seeking behaviour cannot fully account for parties’ organisational choices. Results show that normative and historical considerations play a crucial role in parties’ cost-benefit analysis. It therefore calls upon future research to expand the number of comparative studies and to further assess parties’ goal-seeking behaviour regarding their multilevel organisation.
Electoral Behaviour in a European Union under Stress
Authors: Braun Daniela , Tausendpfund Markus
Published: February 2020

Is electoral behaviour affected by the current challenges of the EU and, if it is, through which channels and mechanisms? This study offers a cross-national analysis together with a broad understanding of both the crisis phenomenon and electoral behaviour. To investigate this research question appropriately, we first distinguish at the most general level between the two main behavioural alternatives at play when it comes to electoral behaviour, namely abstention and vote choice. Second, and no less important, we differentiate between the mechanisms that mediate the relationship between the ‘EU under stress’ and electoral behaviour, namely egocentric and sociotropic economic voting motivations. Drawing on data from the European Election Study 2014, our article provides important insights into the study of electoral behaviour in an EU under stress. First, we are able to show that the multiple crises that have hit the EU have the potential to determine both turnout and the decision to vote for a Eurosceptic party. Second, different mechanisms are in play for each of the two behavioural alternatives: Turnout is clearly related to egocentric determinants and thus depends on individuals’ personal exposure to the financial crisis. Conversely, the decision to vote for a Eurosceptic party is based on a different mechanism. Voters—without necessarily being personally affected by the crisis—have a higher propensity to vote for a Eurosceptic party if they perceive their country to be threatened by such an EU under stress. These findings add to a better understanding of the EU’s multi-level democracy.
Competition in the European Arena: How the Rules of the Game Help Nationalists Gain
Authors: Lefkofridi Zoe
Published: February 2020

Why does the European election fail to produce competition between European policy alternatives despite the increased politicization of European integration and efforts to connect election results to the Commission Presidency via the Spitzenkandidaten process? In this article I theorize the European arena’s incentive structure for political competition by synthesizing Strøm’s (1990) behavioral theory of competitive parties (votes, office, policy) and Bartolini’s (1999, 2000) four dimensions of electoral competition (contestability, availability, decidability, and incumbent vulnerability). I model EU decidability (party differentials on EU policy) and formulate specific expectations about party differentiation by considering parties’ vote-, office-, and policy-seeking motives under the European arena’s specific conditions. How parties behave under the specific incentive structure of the European arena matters for the EU’s development as a polity.
Democracy or Oligarchy? Unequal Representation of Income Groups in European Institutions
Authors: Lefkofridi Zoe , Giger Nathalie
Published: February 2020

In this study we examine the representation of income groups in two EU-level institutions, the Council and the European Parliament. We find that the political positions of these institutions, and especially of the Council, are always on the right compared to European citizens, though closer to the wealthy among them. However, a more systematic analysis of congruence between different income groups and the Council reveals that while the poor are systematically underrepresented, the rich are not systematically over-represented. This holds both when we examine the poor and the rich across the EU as a whole and when we cluster them according to their respective member states.
Political Behavior in the EU Multi-Level System
Authors: Braun Daniela , Gross Martin , Rittberger Berthold
Published: February 2020

Together with its further widening and deepening, the character of the EU has changed fundamentally during the last two decades. Acknowledging this development, the politics-dimension has become visibly more relevant in research on the EU. This “politics turn” is accompanied by an increased interest in research on political behavior of individual and collective actors—voters, parties, interest groups, executive agencies, mass and social media—in the EU multi-level system. The objectives of this thematic issue are to conceptually, empirically, and methodologically capture the different facets of this newly emerged interest in actors’ political behavior in the EU multi-level system. To this end, the thematic issue strives to highlight the connections between political processes and behavior at the European level and other political layers in the EU Member States’ multi-level systems. In particular, we aim to broaden the scope of research on political behavior in the EU and its strong focus on electoral politics across multiple levels of government. To this end, the thematic issue links research on voting behavior with work on party competition, electoral campaigns, public opinion, protest politics, responsiveness, (interest group) representation, government and opposition dynamics, and parliamentary behavior more broadly to the multi-layered systems within EU Member States.
Evolución urbanística de una ciudad portuaria burguesa (Santander, 1750-1941) / Urban development of a bourgeois port city (Santander, 1750-1941)
Authors: Delgado Viñas Carmen
Published: February 2020

Santander comenzó precozmente el proceso de transición urbana. Desde mediados del siglo XVIII, sucesivos proyectos de remodelación de las instalaciones portuarias supusieron la ampliación del suelo urbano a través del relleno de espacios costeros ganados al mar. Los resultados obtenidos en esta investigación confirman que la dinámica de la transición urbana y urbanística forma parte de un proceso general de las ciudades europeas, en particular de las portuarias, con muchos denominadores comunes, aunque con diferentes tiempos y ritmos. Los nuevos medios de desplazamiento y transporte contribuyeron en gran medida a consolidar dichos procesos. Partiendo de estas premisas, aceptadas de forma casi unánime, se puede colegir, a partir del análisis del caso de Santander, que los agentes socioeconómicos fueron determinantes en la dinámica urbana y urbanística, el aumento del volumen poblacional y en la ampliación y reorganización de la superficie del espacio urbano.Santander a commencé tôt le processus de transition urbaine. Depuis le milieu du XVIIIe siècle, les projets successifs de réaménagement des installations portuaires se sont traduits par une expansion des terres urbaines par le remplissage d’espaces côtiers acquis sur la mer. Cette recherche confirme que la dynamique de la transition urbaine et de l’aménagement s’inscrit dans un processus général des villes européennes, en particulier des villes portuaires, avec de nombreux dénominateurs communs, bien que leurs temps et leurs rythmes soient différents. Les nouveaux moyens de transport ont contribué à consolider ces processus. L’analyse du cas de Santander permet de comprendre que les agents socio-économiques ont déterminé la dynamique urbaine et de l’aménagement, la croissance démographique ainsi que l’expansion et la réorganisation de l’espace urbain.Santander began the urban transition process early. Since the mid-eighteenth century, successive port remodeling projects have led to the expansion of urban land through the filling of coastal spaces gained from the sea. This research confirms that the dynamics of the urban transition are part of a general process of European cities, in particular of the port cities, with many common denominators, although with different times and rhythms. The new means of transport contributed to consolidate these processes. It can be gathered, from the analysis of the case of Santander, that socioeconomic agents determined urban dynamics, population growth as well as the expansion and reorganization of urban space.
Análisis del desempeño docente en la educación para el emprendimiento en un contexto español
Authors: López Belmonte Jesús , Pozo Sánchez Santiago , Fuentes Cabrera Arturo , Rodríguez García Antonio Manuel
Published: February 2020

La precariedad laboral actual y la ausencia de iniciativa emprendedora en los jóvenes hacen necesario el fomento de una educación para el emprendimiento  en el espacio escolar para despertar en los discentes la creatividad, la innovación, la autonomía y la búsqueda de oportunidades. El objetivo de este estudio es conocer el estado actual de la educación para el emprendimiento en el profesorado de centros educativos de Granada (España). Para ello, se ha empleado  un cuestionario ad hoc para la recogida de datos y una metodología descriptiva con un diseño no experimental por método de encuesta, con un análisis de estadísticos descriptivos y correlacionales bivariados. La muestra se compone de 312 docentes. Se concluye que la educación para el emprendimiento en tal ciudad sigue en auge, aunque todavía queda un importante margen de mejora para su asentamiento. Los docentes recurren, con escasas dificultades, a una metodología tradicional y a un enfoque teórico para el tratamiento de la competencia emprendedora, lo que implica una instrucción desactualizada y poco motivadora para el alumnado. Ambos géneros docentes fomentan la educación emprendedora aunque potencian finalidades distintas, siendo necesario un reparto más equitativo para una formación integral del discente.
Fomento de la alfabetización de datos en todos los ámbitos
Authors: Arreguit O’Neill Stephanie
Published: February 2020

A medida que las tecnologías proliferan en nuestra sociedad, el mundo está cada vez más interconectado y se recopilan grandes cantidades de datos que contienen información y conocimientos valiosos. Esta creciente cantidad de datos ya ha sido reconocida como un recurso con un gran potencial de aumentar la eficiencia y la sostenibilidad de las organizaciones, las ciudades y las sociedades. Están apareciendo nuevos trabajos dedicados a los datos, y personas que no son expertas en datos deben leer y gestionar datos en su trabajo diario. Por lo tanto, la alfabetización de datos es una habilidad esencial para avanzar en nuestra sociedad de la información. Es fundamental que las personas, los negocios, las instituciones educativas, las comunidades y las sociedades entiendan el valor y las oportunidades que residen en los datos que se utilizan, así como los problemas éticos, de seguridad y de privacidad que pueden surgir por su mal uso. Este artículo aborda la necesidad de la alfabetización de datos, estudia su definición y las habilidades relacionadas, considera la necesidad de dicha alfabetización desde distintas perspectivas, y analiza las consideraciones necesarias para fomentar la alfabetización de datos en distintos ámbitos.
EVALUATION OF THE POTENTIAL FOR RARE EARTH ELEMENT (REE) DEPOSITS RELATED TO THE BORBOREMA PEGMATITE PROVINCE IN NORTHEASTERN BRAZIL.
Authors: Beurlen Hartmut , Rhede Dieter , Thomas Rainer , Da Silva Marcelo Reis , Soares Dwight R.
Published: February 2020

Análises de Elementos de Terras Raras (ETR) com microssonda eletrônica em xenotima, monazita, zircão, torita e uraninita de diferentes fácies de granitos pegmatíticos, supostos serem fonte de pegmatitos complexos de elementos raros (REL) na Província |Pegmatítica da Borborema (PPB) no Nordeste do Brasil, mostraram que a xenotima e monazita são os acessórios mais frequentes com significativa de (ETR).  Conteúdos médios de Nd e Eu em monazita são respectivamente de 13,06 e 0,54 % peso dos óxidos e de Dy, Yb, Gd, e Er respectivamente de 4,77, 3,39, 3,15 e 3,86 em xenotima, considerando apenas os óxidos de ETR mais caros no mercado. Os outros acessórios analisados, como zircão, torita, uraninita não apresentaram teores significativos de ETR. As reduzidas frequências modais da xenotima e monazita tanto nos granitos pegmatíticos como nos próprios pegmatitos tornam uma exploração das rochas duras impraticáveis. Os minerais com maior enriquecimento de ETR poderiam ser concentrados e explotados em placeres fluviais no âmbito da Província Pegmatítica. Há também a possibilidade de enriquecimento dos ETR a partir dos granitos parentais e pegmatitos na interseção dos plateaus paleo-geomorfológicos culminados pelos sedimentos siliciclasticos e caulinizados da Formação Serra dos Martins. Isto porque, na inconformidade na base da mesma ocorreu lateritização e intensa e  profunda caulinização no embasamento cristalino subjacente, em condições similiares às das jazidas de “adsorção iônica” (hoje também conhecidas como “hospedadas em regolito caulinizado”, como Zudong, maior jazida de terras raras pesadas) na China.
Maternal and neonatal outcomes in vacuum assisted births in the government tertiary care hospital in Mandya: a retrospective record-based study
Authors: M. Shwetha , N. Shilpa M.
Published: February 2020

Background: Vacuum extraction and forceps are the two options when an instrument is needed to facilitate a vaginal birth. Vacuum extraction has recently gained popularity because of new designs of vacuum cups with reduced risk of injury to the neonate. Vacuum extraction is one of the evidence-based interventions that can prevent complications by shortening the second stage of labour. The present study has been carried out to evaluate the maternal and neonatal morbidity, mortality and failure associated with vacuum assisted vaginal deliveries, at a Government tertiary care hospital in Mandya, Karnataka, India.Methods: The study was a record-based study including a total of 207 women who underwent vaginal assisted delivery in the form of vacuum assisted deliveries in a period of 6 months from January 2019 to June 2019 at the Government tertiary care hospital in Mandya, Karnataka, India. Records of women who had vacuum assisted deliveries and records of their newborn children were accessed.Results: In our study 41.5% of the subjects were in the age group of 21-25 years. Nearly 3/4th (74.4%) of the subjects were primigravida. More than half (54.1%) of the study subjects had to be put under vacuum assisted techniques for delivery because of the prolonged second stage of labour, failure rate was 0.4%. Out of 207 vacuum assisted deliveries maternal complication rate was 8.21%, 17.3% neonates had NICU admission and 14.97% had perinatal complications.Conclusions: Vacuum assisted vaginal delivery is comparatively a better choice in preventing the complications caused due to prolonged second stage of labour thus reducing the cesareans rate. It is a safe alternative to cesareans delivery in rightly chosen case. Vacuum assisted delivery by a skilled person and a proper technique is associated with lesser maternal and neonatal morbidity.
Implicaciones médicas y legales de la certificación de "nacido vivo" en Colombia
Authors: Olaya Mercedes , Hernández Judy , Rosero Yackeline , Mendoza Daniel , Martínez Darío
Published: February 2020

En Colombia se han dado pasos importantes en el abordaje y manejo de los fetos, embriones y recién nacidos fallecidos, no obstante se requiere mayor difusión de las normas y conceptos existentes, además de implementar algunas medidas faltantes. Es necesario hacer claridad sobre los conceptos ya que las implicaciones legales de la certificación de un niño(a) nacido(a) vivo(a), son muy significativas para los pacientes, las familias, las instituciones y la sociedad. El objetivo del presente documento es hacer una reflexión de los aspectos médicos y legales relevantes acerca del tema.
Inmunohistoquímica en patología de mama. Diferenciación de lesiones complejas benignas y malignas de mama. Un reporte de caso y revisión de la literatura
Authors: Herrera-Arias Omaira del Socorro , Díaz-Cardona Jaime
Published: February 2020

Objetivo: revisar las bases histológicas y los criterios diagnósticos diferenciales de la aplicación de la inmunohistoquímica en la patología mamaria.Caso clínico : se presenta el caso de una paciente con lesión mamaria esclerosante compleja, tipo adenosis microglandular (MGA), que requirió el uso de inmunohistoquímica como técnica auxiliar para diferenciar la lesión de un adenocarcinoma de mama in situ, y definir así el tratamiento.Materiales y métodos: se realizó una búsqueda de la información en las bases de datos Medline vía PubMed, SciELO y en libros de la especialidad. Se reportaron 25 títulos, 12 correspondían con el tema: 4 reportes de caso, 1 con revisión de la literatura, una carta al editor y 7 artículos relacionados de forma más general con el tema.Conclusión: la inmunohistoquímica permite hacer el diagnóstico diferencial de las lesiones mamarias complejas, como la adenosis esclerosante y el cáncer de mama in situ o microinvasor.
Rembrandt: estética, sujeción y corporalidad
Authors: Di Loreto Juan Alberto
Published: February 2020

La producción y el contexto del pintor holandés Rembrandt Harmenszoon van Rijn, permite un análisis de diversos cambios en las concepciones de la subjetividad y el cuerpo que se dan en el mundo europeo a comienzos del siglo XVII. A través de las llamadas lecciones de anatomía y sus autorretratos, Rembrandt da cuenta de la racionalización, la aparición del individuo y objetivación de la corporalidad: de un cuerpo unido a la comunidad en la Edad Media, a la representación en la Modernidad de un cuerpo como un objeto inerte; del sujeto comunitario a la percepción del sujeto como unidad.
Is it worthwhile to offer a daily 'bite-sized' recovery skills group to women on a psychiatric intensive care unit (PICU)?
Authors: Walsh-Harrington Sophie , Corrigall Frances , Elsegood Kelly
Published: February 2020

Research suggests that psychological interventions are necessary and effective for patients in acute mental health settings. Little research has been generated on the feasibility of brief psychological interventions for women in psychiatric intensive care units (PICU). This pilot evaluation
aimed to gauge patients' perceptions of a dialectical behaviour therapy (DBT)-informed intervention, delivered in a 30-minute daily group, in the context of a female PICU.
 Overall, patients endorsed session content as 'worthwhile' and the sessionlength as 'just right'. The DBT-informed
skills were deemed 'helpful for the future'. These preliminary findings support the continuation of this novel, PICU-tailored intervention. Clinical and research implications are discussed.
The relationship between the CYP2C19*17 genetic polymorphism and the efficacy and safety of diazepam in patients with alcohol withdrawal syndrome
Authors: Skryabin V. Yu. , Zastrozhin M. S. , Grishina E. A. , Ryzhikova K. A. , Shipitsyn V. V. , Barna I. V. , Galaktionova T. E. , Sorokin A. S. , Bryun E. A. , Sychev D. A.
Published: February 2020

The aim of our study was to study the relationship between the CYP2C19 genetic polymorphism and the efficacy and safety of diazepam in patients with alcohol withdrawal syndrome in order to develop algorithms for optimizing the therapy of diazepam to reduce the risk of dose-dependent adverse drug reactions and pharmacoresistance.

Materials and methods. The study was conducted on 30 Russian male patients suffering from alcohol withdrawal syndrome. For the treatment of anxiety, fear and emotional tension, patients received diazepam in injections at a dosage of 30,0 mg / day for 5 days. Genotyping was performed by real-time polymerase chain reaction with allele-specific hybridization. The efficacy and safety assessment was performed using psychometric scales and scales for assessing the severity of adverse drug reactions: the Clinical Institute Withdrawal Assessment for Alcohol scale, the visual-analogue scale of the craving for alcohol, and the side-effect scale.

Results. Based on the results of the study, we revealed the differences in the efficacy of therapy in patients with different CYP2C19 -806C>T genotypes: (CC) –12,0 [–15,0; –8,0], (CT + TT) –7.0 [–14,0; –5,0], p = 0,001. The scores on the UKU scale, which was used to evaluate the safety of therapy, were also different: (CC) 8,0 [6,0; 12,0], (CT + TT) 6,0 [6,0; 12,0], p = 0,006.

Conclusion. The relationships between the CYP2C19 genetic polymorphism and the efficacy and safety of diazepam were demonstrated. This should be taken into consideration when prescribing this drug to such patients in order to reduce the risk of adverse drug reactions and pharmacoresistance.
Analysis of probable predictors of aggressive multiple sclerosis
Authors: Spirin N. N. , Kiseleva E. V. , Spirina N. N.
Published: February 2020

Objective: to study the probable laboratory predictors of aggressive multiple sclerosis.

Materials and methods. Antibodies to myelin oligodendrocyte glycoprotein (MOG), antibodies to thyroperoxidase and markers of endothelial dysfunction in blood serum were determined in patients with multiple sclerosis (MS). These indicators were analyzed for different courses of the demyelinating process, for different severity of neurological disorders, and for various sizes of focal lesions on magnetic resonance images.

Results. In patients with aggressive multiple sclerosis, higher titers of antibodies to both myelin oligodendrocyte glycoprotein and thyroperoxidase were detected. A relationship between von Willebrand factor (vWf) and matrix metalloproteinase-9 (MMP-9) and the stage of multiple sclerosis was identified. A higher level of matrix metalloproteinase-9 was detected in MS patients with active foci of the disease on magnetic resonance images.

Conclusion. Thus, antibodies to myelin oligodendrocyte glycoprotein, antibodies to thyroperoxidase, the levels of von Willebrand factor, matrix metalloproteinase-9 and adhesion molecule sPECAM-1 can be used as laboratory predictors of the malignant course of multiple sclerosis.
Features of the distribution of the level of the constant potential in the brain in patients with chronic mercury intoxication
Authors: Shevchenko O. I. , Baskakov I. S. , Lakhman O. L.
Published: February 2020

The aim of the research was to reveal features of distribution of DC-potential level of the brain in patients with chronic mercury intoxication.

Materials and methods. The study involved 33 male patients with chronic mercury intoxication and 38 healthy men (comparison group) who, by the specifics of their professional activities, were not exposed to neurotropic substances. We used the electrophysiological method of neuroenergy mapping.

Results. In the group of patients with chronic mercury intoxication, persons with a low level of constant potential prevailed when compared with the comparison group (36 and 11%, respectively). With a decrease in the level of constant potential in the frontal parts, an increase was observed in the central leads (Fpz – Cz = –1,2 (–6,3–12,6) mV), and with an increase in it, a decrease in the occipital (Fpz-Oz = 4,2 (–4,8–21,4) mV) and the right temporal (Fpz-Td = 0,01 (–6,5–16,3) mV) areas.

Right hemisphere temporal asymmetry was manifested in an increase in the Td-Ts index (p = 0,03) when compared with that of the comparison group, (0,66 ± 0,01) and (–4,34 ± 1,12) mV, respectively. Using discriminant analysis, five reliable diagnostic signs were identified: the values of the parameters of the parietal (Pz), right parietal (Pd), right temporal (Td), central (Cz), occipital (Oz) leads. The most informative sign was the value of the index of the parietal lead (Pz, F = 21,1).

Conclusion. A distinctive neurophysiological sign associated with chronic exposure to metallic mercury vapors is an increase in indices of the parietal, right parietal, right temporal, central, occipital leads compared with those inherent in the normal population.
Pathophysiological mechanisms underlying antipsychotic-induced tardive dyskinesia
Authors: Vayman E. E. , Shnayder N. A. , Neznanov N. G. , Nasyrova R. F.
Published: February 2020

Purpose.To analyze the results of classical and modern studies reflecting the pathophysiological mechanisms of antipsychotic-induced tardive dyskinesia.

Materials and methods. We searched for full-text publications in Russian and English in the databases of E-Library, PubMed, Web of Science and Springer published over the past decade, using keywords (tardive dyskinesia (TD), drug-induced tardive dyskinesia, antipsychotics (AP), neuroleptics, typical antipsychotics, atypical antipsychotics, pathophysiology, etiology and combinations of these words). In addition, the review included earlier publications of historical interest.

Results. The lecture proposed theories of development of AP-induced TD, examining its effect on dopaminergic receptors, dopaminergic neurons, neurons of the basal ganglia, and other theories: activation of estrogen receptors, disorders of melatonin metabolism, disorders of the endogenous opioid system, oxidative stress with predominant oxidation processes, blockade of 5-HT2-receptors, a decrease in the pyridoxine level, genetic predisposition, interaction of AP with the brain trace element – iron, carbonyl stress and immune inflammation and the role of the neurotrophic factor.

Conclusion. The disclosure of the mechanisms of AP-induced TD will allow the development of a strategy for personalized prevention and therapy of the considered neurological complication of the AP-therapy for schizophrenia in real clinical practice.
The possibility of using skin biopsy in the diagnosis of Lafora disease
Authors: Kraeva L. S. , Vtorushin S. V. , Kuzmina A. V. , Kozyritskaya D. V.
Published: February 2020

Lafora disease is a hereditary, autosomal recessive progressive myoclonus epilepsy caused by mutations in the EPM2A (laforin) and EPM2B (malin) genes, with no substantial genotype-phenotype differences between the two. Clinical manifestations of the disease are determined by the accumulation of specific cytoplasmic “amyloid inclusions” consisting of polyglycosans (an abnormally branched glycogen molecule). Polyglycosans, or Lafora bodies, are typically found in the brain, hepatocytes of the liver, skeletal and cardiac muscles, in the ducts of sweat glands, and in the skin. The diagnosis is made following visual, generalized tonic-clonic and myoclonic seizures, progressing dementia, cerebellar ataxia, detection of specific Lafora bodies during sweat gland biopsy and data of genetic testing.

The article describes a clinical case of Lafora disease in a patient with disease onset at 11 years old caused by the mutation in the EPM2A (laforine) gene with focal sensory visual seizures with subsequent generalized tonic-clonic seizures, progressive motor impairments in the form of ataxia and gait abnormality as well as behavioral and cognitive disorders. The presented clinical case demonstrates the need for additional research, such as biopsy and genetic testing, for diagnosing diseases proceeding with resistant epileptic seizures and progressive motor and cognitive impairments.
MUNDO DO TRABALHO
Authors: Freitas Leda Gonçalves , Ghizoni Liliam Deisy
Published: February 2020

Editorial
DEPRESSÃO E USO DE SUBSTÂNCIAS PSICOATIVAS ENTRE PROFESSORES DE UMA UNIVERSIDADE PÚBLICA
Authors: Vieira Alcivan Nunes , Lima Deivson Wendell Costa , Silva Débora Cristina Ezequiel , Feitosa Rúbia Mara Maia , Azevedo Lívia Dayane Sousa
Published: February 2020

O trabalho vem sofrendo mudanças de cunho político, cultural e institucional, as quais tem submetido o trabalhador a uma rotina mais intensa e desgastante. Estas transformações impactaram na organização e nas condições de trabalho docente, sendo associadas ao adoecimento do professor, ao sofrimento psíquico apreendido como depressão e ao consumo de substâncias psicoativas. Objetivou-se descrever as relações entre a depressão e o consumo de substâncias psicoativas entre professores universitários. Pesquisa desenvolvida em uma universidade pública, cujos dados foram coletados pelo Alcohol, Smoking and Substance Involvement Screening Test e Beck Depression Inventory. 80% dos docentes pesquisados afirmou consumo bebida alcoólica e 27,3% derivados do tabaco; dentre as substâncias consideradas ilícitas a maconha se destaca (15,2%). Identificaram-se indícios de depressão concentrados em homens (52,6%), com idade entre 31 a 40 anos, casados e com mestrado (57,9%). Quanto à associação entre o uso de alguma substância psicoativa e a sintomatologia depressiva, esta foi mais prevalente entre aqueles que mencionaram o consumo de bebida alcoólica (68,4%). Mesmo sendo condições determinadas por vários e complexos fatores, existem relações entre a depressão e o uso de substâncias psicoativas entre os docentes no cenário pesquisado; a precarização do trabalho gera sofrimento psíquico e o adoecimento do professor.
A (HÁ) SAÚDE MENTAL DO PROFESSOR DE PSICOLOGIA
Authors: Guimarães Cristiane de Carvalho , Pontes Larissa Diniz de , Silva Flaviany Ribeiro da , Nunes Isabela Ferreira Rocha
Published: February 2020

O estudo da saúde mental do docente tem despertado interesse na comunidade científica. A pressão social do trabalhador da área da educação tem crescido progressivamente e a necessidade de demonstrar um bom desenvolvimento em seu trabalho em consonância com as condições de trabalho, resulta em desgaste psicológico, físico e emocional. A presente pesquisa, desenvolvida com o apoio do Programa de Iniciação Científica da Universidade Estácio de Sá, teve como objetivo verificar a relação entre o processo de trabalho do docente e as condições sob as quais ele se desenvolve, a fim de verificar sua ligação com o surgimento de sofrimento mental dos professores do curso de graduação em psicologia do Campus Nova Iguaçu da referida Universidade. Foram realizadas entrevistas semiestruturadas e aplicação do instrumento de autopreenchimento Self Reporting Questionnaire (SRQ-20). O estresse foi apontado como sintoma prevalente, bem como o cansaço. As condições de trabalho corroboram para o surgimento de afecções otorrinolaringológicas, osteomusculares, doenças psicossomáticas e, em um dos casos, o aparecimento de doença autoimune. Espera-se que esses resultados impulsionem o planejamento de intervenções eficazes no que se refere ao trabalho docente no ensino superior.
DO MONETARY AGGREGATES BELONG IN A MONETARY MODEL? EVIDENCE FROM THE UK
Authors: Ezer Mehmet
Published: February 2020

Conventional monetary models focus on interest rates and omit monetary aggregatesfrom policy discussions. This paper examines whether augmenting the measure ofmonetary policy with monetary aggregates helps determine more robust links betweenpolicy and economic fluctuations. After constructing the Divisia money index for theUK, I employ structural vector autoregression to identify two different UK monetarypolicy regimes. Inclusion of this (correct) measure of money and disentangling themoney supply from demand resolve the price and liquidity puzzles. The results pointto the informational content embedded in monetary aggregates, suggesting theyshould be taken into account in evaluations of monetary policy.
FORECASTING INDONESIAN INFLATION WITHIN AN INFLATION-TARGETING FRAMEWORK: DO LARGE-SCALE MODELS PAY OFF?
Authors: Juhro Solikin M. , Njindan Iyke Bernard
Published: February 2020

We examine the usefulness of large-scale inflation forecasting models in Indonesiawithin an inflation-targeting framework. Using a dynamic model averaging approachto address three issues the policymaker faces when forecasting inflation, namely,parameter, predictor, and model uncertainties, we show that large-scale modelshave significant payoffs. Our in-sample forecasts suggest that 60% of 15 exogenouspredictors significantly forecast inflation, given a posterior inclusion probability cut-offof approximately 50%. We show that nearly 87% of the predictors can forecast inflationif we lower the cut-off to approximately 40%. Our out-of-sample forecasts suggest thatlarge-scale inflation forecasting models have substantial forecasting power relative tosimple models of inflation persistence at longer horizons.
DOES FINTECH MATTER FOR INDONESIA’S ECONOMIC GROWTH?
Authors: Narayan Seema Wati
Published: February 2020

This paper investigates the role of financial technology (FinTech) in propelling economic growth in Indonesia from 1998 to 2018. The FinTech industry employs a technology-based business model to provide financial services, including lending, payment, investment, and financing services. The study is motivated by endogenous growth theory, which seeks to explain technology as the most important driver of economic growth. The study finds that FinTech startups are positively correlated with Indonesia’s economic growth. FinTech firms in their first year are found to be disruptive, but they fail to have serious consequences on Indonesia’s economic growth; however, they seem to significantly encourage economic growth in their second year. These findings are derived after accounting for other important growth determinants, namely, capital per labor, foreign direct investment (FDI), stock market development, and trade openness.
House Ball Community Leaders’ Perceptions of HIV and HIV Vaccine Research
Authors: Alio Amina P. , Sibley Candace , Ouedraogo Halimah S. , Wallace Stephaun E. , Wakefield Steven , Humes Damon L. , Fields Sheldon D. , Keefer Michael C.
Published: February 2020

Background or Objectives: Worldwide, men who have sex with men (MSM) and Transgender persons are vulnerable to psychosocial factors associated with high risk for HIV, and suffer disproportionately high rates of HIV/AIDS. In the United States (US), the House Ball Community (HBC) is a social network comprised predominantly of Black and Hispanic MSM and Transgender persons who reside in communal settings. This study explores Western New York HBC leaders’ perceptions of HIV in their communities and their knowledge of HIV prevention strategies, including HIV vaccine trials.

Methods: The project was conducted using an exploratory approach based on the principles of Community-Based Participatory Research (CBPR) methods. An HIV behavioral risk assessment provided descriptive data, while qualitative measures explored psychosocial and behavioral factors.

Results: Behavioral assessments indicated high levels of risky sexual behaviors and experiences of violence. Interviews with 14 HBC leaders revealed that knowledge of HIV and local HIV vaccines trials was limited. Barriers to HIV knowledge included fear of peer judgment, having inaccurate information, and lack of formal education. Experiencing violence was identified as barrier to positive health behavior. Nevertheless, the HBC was described as a safe and creative space for marginalized MSM and Transgender youth.

Conclusion and Global Health Implications: Findings suggest that the interrelation between health problems and social context amplify HIV risk in the HBC. The organizational structure and resources of the HBC, and MSM/Transgender communities worldwide can be instrumental in informing interventions to address HIV-related risk behaviors and create appropriate recruitment tools to ensure their representation in HIV research.

Key words: • LGBT • HIV • MSM • Transgender populations • MSM/Transgender psychosocial • HIV risk factors • HIV and black/Latino MSM • Syndemic factors • MSM/T ransgender communities

 

Copyright © 2020 Alio et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
Variation of prevalence of malaria, parasite density and the multiplicity of Plasmodium falciparum infection throughout the year at three different health centers in Brazzaville, Republic of Congo
Authors: MAYENGUE - PEMBE ISSAMOU , Batsimba Dezi Kouhounina , Niama Roch Fabien , Ottia Reyna Ibara , Malonga-Massanga Alida , Fila-Fila Grâce Petula Urielle , Ahombo Gabriel , Kobawila Simon Charles , Parra Henri Joseph
Published: February 2020

Background: In the Republic of Congo, hot temperature and seasons distortions observed may impact the development of malaria parasites. We investigate the variation of malaria cases, parasite density and the multiplicity of Plasmodium falciparum infection throughout the year in Brazzaville. Methods: From May 2015 to May 2016, suspected patients with uncomplicated malaria were enrolled at the Hôpital de Mfilou, CSI « Maman Mboualé», and the Laboratoire National de Santé Publique. For each patient, thick blood was examined and parasite density was calculated. After DNA isolation, MSP1 and MSP2 genes were genotyped.Results : A total of 416, 259 and 131 patients with suspected malaria were enrolled at the CSI «Maman Mboualé», Hôpital de Mfilou and the Laboratoire National de Santé Publique respectively. Proportion of malaria cases and geometric mean parasite density were higher at the CSI «Maman Mboualé» compared to over sites (P-value ˂0.001). However the multiplicity of infection was higher at the Hôpital de Mfilou ( P-value ˂0.001). At the Laboratoire National de Santé Publique, malaria cases and multiplicity of infection were not influenced by different seasons. However, variation of the mean parasite density was statistically significant ( P-value ˂0.01). Higher proportions of malaria cases were found at the end of main rainy season either the beginning of the main dry season at the Hôpital de Mfilou and the CSI «Maman Mboualé»; while, lowest proportions were observed in September and January and in September and March respectively. Higher mean parasite densities were found at the end of rainy seasons with persistence at the beginning of dry seasons. Lowest mean parasite densities were found during dry seasons, with persistence at the beginning of rainy seasons. Fluctuation of the multiplicity of infection throughout the year was observed without significance between seasons.Conclusion: The current study suggests that malaria transmission is still variable between the north and south parts of Brazzaville. Seasonal fluctuations of malaria cases and mean parasite densities were observed with some extension to different seasons. Thus, both meteorological and entomological studies are needed to update the season’s periods as well as malaria transmission intensity in Brazzaville.
Analysis of fungal bloodstream infection in intensive care units in the Meizhou region of China: species distribution and resistance and the risk factors for patient mortality
Authors: Xiao Guang-Wen , Liao Wan-qing , Zhang Yuenong , Luo Xiaodong , Zhang Cailing , Li Guodan , Yang Yingping , Xu Yunyao
Published: February 2020

Background : Fungal bloodstream infections (FBI) among intensive care unit (ICU) patients are increasing. Our objective was to characterize the fungal pathogens that cause bloodstream infections and determine the epidemiology and risk factors for patient mortality among ICU patients in Meizhou, China. Methods Eighty-one ICU patients with FBI during their stays were included in the study conducted from January 2008 to December 2017. Blood cultures were performed and the antimicrobial susceptibility profiles of the resulting isolates were determined. Logistic multiple regression and receiver operating characteristics (ROC) curve analysis were used to assess the risk factors for mortality among the cases. Results The prevalence of FBI in ICU patients was 0.38% (81/21,098) with a mortality rate of 35.8% (29/81). Ninety-eight strains of bloodstream-infecting fungi, mainly Candida spp., were identified from these patients. Candida albicans was most common (42.9%). Two strains of C. parapsilosis were no-sensitive to caspofungin, C. glabrata were less than 80% sensitive to azole drugs.. Logistic multiple regression showed that age, serum albumin, Acute Physiology and Chronic Health Evaluation (APACHE) II score, three or more underlying diseases, and length of stay in ICU were independent risk factors for mortality in FBI. ROC curve analysis showed that APACHE II scores > 19 and serum albumin ≤ 25g/L were the best predictors of mortality. Conclusion: Candida spp. predominated with high mortality rates among cases of FBI in ICU. Thus, clinical staff should enhance overall patient monitoring and concurrently monitor fungal susceptibility to reduce mortality rates.
H19/miR-194/E2F3 regulating loop promotes gastric cancer growth and metastasis
Authors: Qin Wanxiang , Shi Ying , Zhu Dan , Chen Yaohua , Li Yuping , Cui Jian
Published: February 2020

Background
Gastric cancer (GC) is one of the most frequent malignant digestive tumors and second fatal cancer. This study was to investigate whether lncRNA-H19 can regulate E2F3 expression through competitive binding to microRNA-194 (miR-194), thus regulating GC growth and metastasis.
Methods
H19, miR-194, and E2F3 expression levels in GC tissues and cell lines were investigated using quantitative reverse transcriptase-polymerase chain reaction (QRT-PCR). Meanwhile, the mRNA levels of H19 and E2F3 in gastric cancer tissues were also analyzed through the GEPIA web tool. The binding condition of miR-194 with H19 and E2F3 was investigated using a dual-luciferase reporter gene assay. The regulatory effects of H19 on proliferative, migratory, and invasive abilities of AGS cells and SGC-7901 cells were detected by transwell assay and cell counting kit-8 (CCK-8). Genes involved in proliferation, migration, and invasion (PCNA, Vimentin, and N-cadherin) were determined using QRT-PCR and western blot. The regulatory interaction between H19 and miR-194, miR-194, and E2F3 were investigated using rescue experiments.
Results
The results revealed that H19 was highly expressed in GC tissues and cell lines than those of controls. Downregulated H19 decreased the proliferation, migration, and invasion of AGS cells and SGC-7901 cells. H19 was demonstrated that being the molecular sponge of miR-194 in regulating the growth of the GC cells. The level of E2F3 expression was also found significantly higher in GC tissues and cell lines than those of controls. And then, the mimics of miR-194 inhibited the expression of E2F3 in the GC cells. CCK-8 assay showed decreased proliferative ability induced by miR-194 mimics were reversed by E2F3 overexpression. Transwell assays showed decreased migratory and invasive ability induced by miR-194 mimics were reversed by E2F3 overexpression.
Conclusions
This study demonstrates that H19 promotes GC growth and metastasis by regulating E2F3 via competitive binding to miRNA-194.
Transgenic aspens (Populus tremula) with the xyloglucanase gene from Penicillium canescens keep faster growth under semi-natural conditions
Authors: Vidyagina Elena O. , Subbotina Natalia M. , Belyi Vladimir A. , Lebedev Vadim G. , Krutovsky Konstantin V. , Shestibratov Konstantin A.
Published: February 2020

Background Recombinant carbohydrases genes are used to produce transgenic woody plants with improved phenotypic traits. However, cultivation of such plants in open field is challenged by a number of problems. Therefore, additional research is needed to alleviate them. Results Results of successful cultivation of the transgenic aspens (Populus tremula) carrying the recombinant xyloglucanase gene (sp-Xeg) from Penicillium canescens in semi-natural conditions are reported in this paper for the first time. Change of carbohydrate composition of wood was observed in transgenic aspens carrying the sp-Xeg gene. The transformed transgenic line PtXVXeg1b demonstrated accelerated growth and increased content of cellulose in wood of trees growing in both greenhouse and outside in comparison with the control untransformed line Pt. The accelerated growth was observed also in the transgenic line PtXIVXeg1c. Thicker cell-wall and longer xylem fiber were also observed in both these transgenic lines. Undescribed earlier considerable reduction in the wood decomposition rate of the transgenic aspen stems was also revealed for the transformed transgenic lines. The decomposition rate was approximately twice as lower for the transgenic line PtXVXeg3b in comparison with the control untransformedline Pt. Conclusion Our results showed that the plants carrying the recombinant sp-Xeg gene do not demonstrate a decrease in growth parameters in semi-natural conditions. However, in some transgenic lines, a change in the carbohydrate composition of the wood, an increase in the cell wall thickness and a decrease in the rate of decomposition of wood are observed.