bluuebunny/crossref_metadata_2025 huggingface dataset:
Risk Factors for Rivaroxaban-Related Bleeding Events—Possible Role of Pharmacogenetics: Case Series
Authors: Šimičević Livija , Slišković Ana Marija , Kirhmajer Majda Vrkić , Ganoci Lana , Holik Hrvoje , Palić Jozefina , Samardžić Jure , Božina Tamara
Published: February 2023

Non-vitamin K antagonist oral anticoagulants’ interindividual trough concentration variability affects efficacy and safety, especially in bleeding events. Rivaroxaban is metabolised via CYP3A4/5-, CYP2J2-, and CYP-independent mechanisms and is a substrate of two transporter proteins: ABCB1 (MDR1, P-glycoprotein) and ABCG2 (BCRP; breast-cancer-resistance protein). The polymorphisms of these genes may possibly affect the pharmacokinetics of rivaroxaban and, consequently, its safety profile. Rivaroxaban variability may be associated with age, liver and kidney function, concomitant illness and therapy, and pharmacogenetic predisposition. This case series is the first, to our knowledge, that presents multiple risk factors for rivaroxaban-related bleeding (RRB) including age, renal function, concomitant diseases, concomitant treatment, and pharmacogenetic data. It presents patients with RRB, along with their complete clinical and pharmacogenetic data, as well as an evaluation of possible risk factors for RRB. Thirteen patients were carriers of ABCB1, ABCG2, CYP2J2, and/or CYP3A4/5 gene polymorphisms. Possible drug–drug interactions with increased bleeding risk were identified in nine patients. Six patients had eGFR <60 mL/min/1.73 m2. Our data suggest a possible role of multiple factors and their interactions in predicting RRB; however, they also indicate the need for further comprehensive multidisciplinary research to enable safer use of this product based on a personalised approach.
Design of a Broadband Fiber Optic Mode Coupler for Multimode Optical Coherence Tomography
Authors: Hu Dora Juan Juan , Liu Linbo , Dong Hui , Zhang Hailiang
Published: February 2023

In this paper, we propose an optical fiber-based broadband mode coupler for multimode optical coherence tomography (OCT) in the O-band (1.26–1.36 μm). The proposed device uses a tapered few-mode fiber (FMF) to lower the effective mode index of the selected higher-order mode, which can be phase matched to the fundamental mode of the single-mode fiber (SMF). The tapered FMF and the SMF are side polished to reduce the core-to-core separation to achieve efficient mode coupling. Key design parameters such as the tapering ratio of the FMF, FMF core to SMF core separation, coupler length, and coupling ratio in the O-band are studied thoroughly. Higher-order modes of the FMF will be effectively coupled from the fundamental mode of SMF in the sample arm of the multimode OCT system. The reflected signals of the higher-order modes from the sample will be separated into several single-mode signals using the same fiber device before interfering with the reference light, which was not possible before. The proposed fiber device will be a key component to efficiently achieve multimode OCT operation with better signal collection efficiency and improved penetration depth for deep tissue imaging.
1.1–1.6 μm Multi-Wavelength Random Raman Fiber Laser
Authors: Hu Chunhua , Sun Ping
Published: February 2023

Multi-wavelength fiber lasers have attracted great attention due to their application value in many fields. In this work, we demonstrated a seven-wavelength random Raman fiber laser in the range of 1.1–1.6 μm. A piece of 1-km-long high Raman gain optical fiber is utilized as the gain medium. The 1st-order to 7th-order Stokes waves are located, respectively, at 1133 nm, 1194 nm, 1260 nm, 1332 nm, 1414 nm, 1504 nm, and 1606 nm. In the 3-dB bandwidth of optical spectra of 1st-order and 2nd-order Stokes waves, four peaks with an average spacing of 1 nm and 20 peaks with an average spacing of 0.45 nm respectively, are recorded. Pumped by a 1080 nm/12.5 W/220 ns laser, the maximum output power can reach 4.16 W, corresponding to the optical-to-optical conversion efficiency of ~30.7%.
Taxonomic Advances from Fungal Flora Associated with Ferns and Fern-like Hosts in Northern Thailand
Authors: Seifollahi Elaheh , de Farias Antonio Roberto Gomes , Jayawardena Ruvishika Shehali , Hyde Kevin D.
Published: February 2023

Ferns are one of the most significant plant groupings that comprise a substantial proportion of the plant flora due to the fact of their great diversity, especially in tropical areas. The biodiversity of fungi associated with ferns and fern-like hosts has also received little attention in studies. Plant samples were collected from diseased and dead plants of ten fern or fern-like species from Chiang Rai in northern Thailand. Forty-one isolates were selected from the obtained isolates for molecular and morphological analysis, with a focus on pathogenic fungal genera and consideration of the diversity in host and geographical location. Twenty-six species belonging to seven genera (Colletotrichum, Curvularia, Diaporthe, Fusarium, Lasiodiplodia, Neopestalotiopsis, and Pestalotiopsis) in six families were identified. Thirty new hosts, eight new geographical hosts, and one new species, Colletotrichum polypodialium, are described. Nepestalotiopsis phangngaensis, N. pandancola, Diaporthe tectonendophytica, D. chiangraiensis, and D. delonicis were isolated for the first time from leaf spots. Additionally, new reservoirs and geographical locations for species previously isolated from leaf spots or whose pathogenicity was established were found. However, more studies are necessary to prove the pathogenicity of the fungi isolated from the leaf spots and to identify the fungi associated with other species of ferns.
Arbuscular Mycorrhizal Symbiosis Improves Ex Vitro Acclimatization of Sugarcane Plantlets (Saccharum spp.) under Drought Stress Conditions
Authors: Spinoso-Castillo José Luis , Moreno-Hernández María del Rosario , Mancilla-Álvarez Eucario , Sánchez-Segura Lino , Sánchez-Páez Ricardo , Bello-Bello Jericó Jabín
Published: February 2023

The symbiotic associations between arbuscular mycorrhizal fungi (AMF) and plants can induce drought stress tolerance. In this study, we evaluated the effect of Glomus intraradices, a mycorrhizal fungus, on the ex vitro development and survival of sugarcane plantlets subjected to drought stress during the acclimatization stage of micropropagation. In vitro obtained sugarcane plantlets (Saccharum spp. cv Mex 69–290) were inoculated with different doses of G. intraradices (0, 100, and 200 spores per plantlet) during greenhouse acclimatization. Sixty days after inoculation, plantlets were temporarily subjected to drought stress. We evaluated the survival rate, total chlorophyll, total protein, carotenoids, proline, betaine glycine, soluble phenolic content, and antioxidant capacity every 3 days for 12 days. Symbiotic interaction was characterized by microscopy. Our results showed that the survival rate of inoculated plants was higher in 45% than the treatment without mycorrhizae. Total chlorophyll, protein, proline, betaine glycine content, and antioxidant capacity were increased in AMF inoculated plants. The soluble phenolic content was higher in non-inoculated plants than the treatment with mycorrhizae during the drought stress period. Microscopy showed the symbiotic relationship between plant and AMF. The early inoculation of 100 spores of G. intraradices per sugarcane plantlet during the acclimatization stage could represent a preconditioning advantage before transplanting into the field and establishing basic seedbeds.
Updated Organic Composition and Potential Therapeutic Properties of Different Varieties of Olive Leaves from Olea europaea
Authors: Ferreira Diana Melo , de Oliveira Natália M. , Chéu Maria Helena , Meireles Diana , Lopes Lara , Oliveira Maria Beatriz , Machado Jorge
Published: February 2023

Olea europaea L. folium merits further exploration of the potential of its substrates for therapeutic supplements. Quantitative and qualitative analyses were conducted on samples of Madural, Verdeal, and Cobrançosa elementary leaves and leaf sprouts (mamões) collected in the region of Valpaços, Portugal. Organic analysis assessed the moisture content, total carbohydrates, ash, protein, and fat contents, total phenolic content (TPC), vitamin E, and fatty acid (FA) profiles. Moisture content was determined through infrared hygrometry and TPC was determined by a spectrophotometric method. Concerning organic analysis, all leaf samples showed similar moisture content, though Cobrançosa’s leaf sprouts and Verdeal’s elementary leaves had slightly lower contents. Meanwhile, these cultivars also showed a higher TPC, α-tocopherol isomer, and fatty acid composition (FAC). FAC in all samples exhibited higher contents of PUFA and SFA than MUFA, with a predominance of linolenic and palmitic acids. Organic analyses of Cobrançosa’s leaf sprouts and Verdeal’s elementary leaf extracts allow for the prediction of adequate physiological properties regarding neuroinflammatory, neurobehavioral, metabolic, cardiovascular, osteo-degenerative, anti-ageing, pulmonary, and immunological defense disorders. These physiological changes observed in our preliminary in silico studies suggest an excellent nutraceutical, which should be borne in mind during severe pandemic situations.
Volatile Constituents from Catasetum (Orchidaceae) Species with Occurrence in the Brazilian Amazon
Authors: de Vasconcelos Franciléia M. , Andrade Eloisa Helena A. , Teixeira Luiz Otávio A. , Figueiredo Pablo Luis B. , Maia José Guilherme S.
Published: February 2023

Background: Catasetum Rich. ex Kunth is a genus of Neotropical orchids distributed in Central and South American regions. In the Brazilian Amazon, there are more than 60 species of Catasetum. The floral aromas of orchids are little known, particularly of Catasetum species. This work aimed to analyze the chemical constituents of the volatile concentrates of eight Catasetum specimens from the Amazon: C. alatum (1), C. albovirens (2), C. barbatum (1), C. ciliatum (2), C. galeritum (1), and C. gnomus (1). Methods: Gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) analyzed and identified the constituents of the volatile concentrates, and principal component analysis (PCA) and hierarchical cluster analysis (HCA) were used in the multivariate statistical analysis. Results: The Catasetum main constituents in descending order and above 10% were trans-geranylgeraniol, 1,4-dimethoxybenzene, linalool, 2-phenylethyl acetate, geraniol, 7-epi-1,2-dehydro-sesquicineole, 1,8-cineole, benzyl acetate, limonene, methyl salicylate, (E)-β-farnesene, anisyl butyrate, cis-carvone oxide, cadin-4-en-10-ol, indole, α-pinene, and δ-cadinene. Conclusions: Multivariate statistical analysis of Catasetum species showed that C. barbatum, C. albovirens, and C. gnomus are distinct from the other studied species, while C. alatum, C. ciliatum, and C. galeritum presented the same primary classes of compounds. These results contribute to a better understanding of the genus Catasetum chemotaxonomy.
Characterization and Therapeutic Applications of Biosynthesized Silver Nanoparticles Using Cassia auriculate Flower Extract
Authors: Sabapathi Nadana , Ramalingam Srinivasan , Aruljothi Kandasamy Nagarajan , Lee Jintae , Barathi Selvaraj
Published: February 2023

The current study analyzes the biosynthesis of silver nanoparticles using the Cassia auriculate flower extract as the reducing and stabilizing agent. The Cassia auriculate- silver nanoparticles (Ca-AgNPs) obtained are characterized by UV–Vis spectroscopy, Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM) analysis. The results of the spectral characterization have revealed that the surface Plasmon resonance band observed at 448 nm confirms the formation of AgNPs. TEM analysis of the Ca-AgNPs was a predominately spherical shape with a size assortment of 30 to 80 nm and an angular size of 50 nm. The well-analyzed Ca-AgNPs were used in various biological assays, including healthcare analysis of antimicrobial, antioxidant (DPPH), and cytotoxic investigations. Ca-AgNPs showed efficient free radical scavenging activity and showed excellent antimicrobial activity against to pathogenic strains. The occurrence of Ca-AgNPs lead to reduced Live/Dead ratio of bacteria (from 36.97 ± 1.35 to 9.43 ± 0.27) but improved the accumulation of bacterial clusters. The cytotoxicity of Ca-AgNPs was carried out by MTT assay against MCF-7 breast cancer cells and a moderate cytotoxic. The approach of flower extract-mediated synthesis is a cost-efficient, eco-friendly, and easy alternative to conventional methods of silver nanoparticle synthesis.
Sustainable Soil Management: Effects of Clinoptilolite and Organic Compost Soil Application on Eco-Physiology, Quercitin, and Hydroxylated, Methoxylated Anthocyanins on Vitis vinifera
Authors: Cataldo Eleonora , Fucile Maddalena , Manzi Davide , Masini Cosimo Maria , Doni Serena , Mattii Giovan Battista
Published: February 2023

Climate change and compostinS1g methods have an important junction on the phenological and ripening grapevine phases. Moreover, the optimization of these composting methods in closed-loop corporate chains can skillfully address the waste problem (pomace, stalks, and pruning residues) in viticultural areas. Owing to the ongoing global warming, in many wine-growing regions, there has been unbalanced ripening, with tricky harvests. Excessive temperatures in fact impoverish the anthocyanin amount of the must while the serious water deficits do not allow a correct development of the berry, stopping its growth processes. This experiment was created to improve the soil management and the quality of the grapes, through the application of a new land conditioner (Zeowine) to the soil, derived from the compost processes of industrial wine, waste, and zeolite. Three treatments on a Sangiovese vineyard were conducted: Zeowine (ZW) (30 tons per ha), Zeolite (Z) (10 tons per ha), and Compost (C) (20 tons per ha). During the two seasons (2021–2022), measurements were made of single-leaf gas exchange and leaf midday water potential, as well as chlorophyll fluorescence. In addition, the parameters of plant yield, yeast assimilable nitrogen, technological maturity, fractionation of anthocyanins (Cyanidin-3-glucoside, Delphinidin-3-glucoside, Malvidin-3-acetylglucoside, Malvidin-3-cumarylglucoside, Malvidin-3-glucoside, Peonidin-3-acetylglucoside, Peonidin-3-cumarylglucoside, Peonidin-3-glucoside, and Petunidin-3-glucoside), Caffeic Acid, Coumaric Acid, Gallic Acid, Ferulic Acid, Kaempferol-3-O-glucoside, Quercetin-3-O-rutinoside, Quercetin-3-O-glucoside, Quercetin-3-O-galactoside, and Quercetin-3-O-glucuronide were analyzed. The Zeowine and zeolite showed less negative water potential, higher photosynthesis, and lower leaf temperature. Furthermore, they showed higher levels of anthocyanin accumulation and a lower level of quercetin. Finally, the interaction of the beneficial results of Zeowine (soil and grapevines) was evidenced by the embellishment of the nutritional and water efficiency, the minimizing of the need for fertilizers, the closure of the production cycle of waste material from the supply chain, and the improvement of the quality of the wines.
Elucidating Biological Functions of 9-cis-Epoxycarotenoid Dioxygenase Genes Involved in Seed Dormancy in Paeonia lactiflora
Authors: Fei Riwen , Guan Shixin , Duan Siyang , Ge Jiayuan , Sun Tianyi , Sun Xiaomei
Published: February 2023

Abscisic acid (ABA) is a major phytohormone affecting seed dormancy and germination in plants. ABA is synthesized mainly through the C40 carotenoid pathway. In the ABA biosynthesis pathway, 9-cis-epoxycarotenoid dioxygenase (NCED) is a key rate-limiting enzyme that regulates the accumulation and content of ABA. However, the role of the NCED gene in perennial plants with complex seed dormancy remains largely unknown. Here, we cloned two differentially expressed paralogs of herbaceous peony NCED genes, named PlNCED1 and PlNCED2, and further identified their involvement in seed dormancy from perennial herbaceous peony experiencing complex double seed dormancy. The deduced PlNCED amino acid sequences had high sequence homology with NCED sequences from other plants and contained the typical conserved RPE65 domain of the NCED family. Phylogenetic analysis showed that PlNCED1 and PlNCED2 have a close relationship with PoNCED in Paeonia ostii and VvNCED6 in Vitis vinifera, respectively. A subcellular localization assay demonstrated that the PlNCED1 protein resided within the nucleus, while the PlNCED2 protein was located in the cytoplasm, indicating their different roles in the biosynthesis of ABA. Furthermore, the content of endogenous ABA in transgenic calluses showed that PlNCEDs were positively correlated with ABA content. Both PlNCED transgenic Arabidopsis lines and the functional complementation of Arabidopsis NCED mutants found that PlNCEDs promoted seed dormancy and delayed seed germination. These results reveal that PlNCEDs participate in the seed dormancy of herbaceous peony by regulating the accumulation of endogenous ABA.
Nutrient Sufficiency Ranges for Corn at the Early Growth Stage: Implications for Nutrient Management
Authors: Amissah Solomon , Ankomah Godfred , Agyei Benjamin K. , Lee Robert D. , Harris Glendon H. , Cabrera Miguel , Franklin Dorcas H. , Diaz-Perez Juan C. , Habteselassie Mussie Y. , Sintim Henry Y.
Published: February 2023

Growers rely on nutrient sufficiency ranges (NSRs) after plant tissue analysis to inform timely nutrient management decisions. The NSRs are typically established from survey studies across multiple locations, which could be confounded by several abiotic and biotic factors. We conducted field studies in 2020, 2021, and 2022 to validate the lower thresholds of the NSRs for corn (Zea mays) at the early growth stage as reported in the Southern Cooperative Series Bulletin #394. We induced various corn nutritional levels by making different nutrient application rates. If the NSRs are valid, samples within the same replication that satisfy the NSRs of all nutrients should have similar biomass accumulation. The results showed that the NSRs were not valid under the conditions tested. In total, 47.6% of the samples satisfied all the lower thresholds of the NSRs, and 25.4% of those samples had relative biomass <50%, with relative biomass even as low as 24.2% observed. Moreover, 9.6% of the total samples had P and Cu levels that failed to meet the lower threshold but still had relative biomass ≥75%. The findings highlight the sensitivity of corn to nutrient imbalance and the need to optimize nutrient diagnostic methods at the early growth stage.
Interaction of Plants and Endophytic Microorganisms: Molecular Aspects, Biological Functions, Community Composition, and Practical Applications
Authors: Aleynova Olga A. , Kiselev Konstantin V.
Published: February 2023

Endophytes are microorganisms that live asymptomatically inside plant tissues [...]
Designing Multistimuli-Responsive Anisotropic Bilayer Hydrogel Actuators by Integrating LCST Phase Transition and Photochromic Isomerization
Authors: Long Shijun , Huang Jiacheng , Xiong Jiaqiang , Liu Chang , Chen Fan , Shen Jie , Huang Yiwan , Li Xuefeng
Published: February 2023

Stimuli-responsive hydrogel actuators have attracted tremendous interest in switches and microrobots. Based on N-isopropylacrylamide (NIPAM) monomers with LCST phase separation and photochromic molecule spiropyran which can respond to ultraviolet light and H+, we develop a novel multistimuli-responsive co-polymer anisotropic bilayer hydrogel, which can undergo complex deformation behavior under environmental stimuli. Diverse bending angles were achieved based on inhomogeneous swelling. By controlling the environmental temperature, the bilayer hydrogels achieved bending angles of 83.4° and −162.4° below and above the critical temperature of PNIPAM. Stimulated by ultraviolet light and H+, the bilayer hydrogels showed bending angles of −19.4° and −17.3°, respectively. In addition, we designed a strategy to enhance the mechanical properties of the hydrogel via double network (DN). The mechanical properties and microscopic Fourier transform infrared (micro-FTIR) spectrum showed that the bilayer hydrogel can be well bonded at the interfaces of such bilayers. This work will inspire the design and fabrication of novel soft actuators with synergistic functions.
Chitin and Chitosan as Polymers of the Future—Obtaining, Modification, Life Cycle Assessment and Main Directions of Application
Authors: Piekarska Klaudia , Sikora Monika , Owczarek Monika , Jóźwik-Pruska Jagoda , Wiśniewska-Wrona Maria
Published: February 2023

Natural polymers are very widespread in the world, which is why it is so important to know about the possibilities of their use. Chitin is the second most abundant reproducible natural polymer in nature; however, it is insoluble in water and basic solvents. Chitin is an unused waste of the food industry, for which there are possibilities of secondary management. The research led to obtaining a soluble, environmentally friendly form of chitin, which has found potential applications in the many fields, e.g., medicine, cosmetics, food and textile industries, agriculture, etc. The deacetylated form of chitin, which is chitosan, has a number of beneficial properties and wide possibilities of modification. Modification possibilities mean that we can obtain chitosan with the desired functional properties, facilitating, for example, the processing of this polymer and expanding the possibilities of its application, also as biomimetic materials. The review contains a rich description of the possibilities of modifying chitin and chitosan and the main directions of their application, and life cycle assessment (LCA)—from the source of the polymer through production materials to various applications with the reduction of waste.
Electrohydrodynamic Techniques for the Manufacture and/or Immobilization of Vesicles
Authors: Sánchez-Cerviño María Celina , Fuioaga Codrin Paul , Atanase Leonard Ionut , Abraham Gustavo A. , Rivero Guadalupe
Published: February 2023

The development of accurate drug delivery systems is one of the main challenges in the biomedical field. A huge variety of structures, such as vesicles, nanoparticles, and nanofibers, have been proposed as carriers for bioactive agents, aiming for precision in administration and dosage, safety, and bioavailability. This review covers the use of electrohydrodynamic techniques both for the immobilization and for the synthesis of vesicles in a non-conventional way. The state of the art discusses the most recent advances in this field as well as the advantages and limitations of electrospun and electrosprayed amphiphilic structures as precursor templates for the in situ vesicle self-assembly. Finally, the perspectives and challenges of combined strategies for the development of advanced structures for the delivery of bioactive agents are analyzed.
Nitrogen-Rich Polyaniline-Based Activated Carbon for Water Treatment: Adsorption Kinetics of Anionic Dye Methyl Orange
Authors: Al-Odayni Abdel-Basit , Alsubaie Faisal S. , Saeed Waseem Sharaf
Published: February 2023

In the present work, a nitrogen-rich activated carbon (PAnAC) was prepared using polyaniline (PAn) as a precursor to represent one possible conversion of nitrogen-containing polymeric waste into a valuable adsorbent. PAnAC was fabricated under the chemical activation of KOH and a PAn precursor (in a 4:1 ratio) at 650 °C and was characterized using FTIR, SEM, BET, TGA, and CHN elemental composition. The structural characteristics support its applicability as an adsorbent material. The adsorption performance was assessed in terms of adsorption kinetics for contact time (0–180 min), methyl orange (MO) concentration (C0 = 50, 100, and 200 ppm), and adsorbent dosages (20, 40, and 80 mg per 250 mL batch). The kinetic results revealed a better fit to a pseudo-second-order, specifically nonlinear equation compared to pseudo-first-order and Elovich equations, which suggests multilayer coverage and a chemical sorption process. The adsorption capacity (qe) was optimal (405.6 mg/g) at MO C0 with PAnAC dosages of 200 ppm and 40 mg and increased as MO C0 increased but decreased as the adsorbent dosage increased. The adsorption mechanism assumes that chemisorption and the rate-controlling step are governed by mass transfer and intraparticle diffusion processes.
Dynamic Fracture Resistance under Plane Strain Conditions of High-Density Polyethylene Nanoclay Composites
Authors: López-Cabrera H. R. , Figueroa-López U. , Taylor A. C. , Guevara-Morales A.
Published: February 2023

Polymer nanoclay composites have received significant attention due to their substantially enhanced mechanical, thermal and barrier properties. However, the effect of these nanoclays on the dynamic fracture resistance of a polymer matrix during fast fracture events has not been documented. In this study, the effect of nanoclay addition on the rapid crack propagation (RCP) resistance of high-density polyethylene (HDPE) was investigated through the high-speed double torsion test. Results showed that the addition of 1, 3, and 5% of nanoclays improved the dynamic fracture resistance under the plane strain conditions (Gd1) of HDPE up to 65%. An increase in the storage and loss modulus, and a decrease in crystallinity and melt flow index with nanoclay content was also found. Although the presence of agglomerates can hinder the enhancement of Gd1 as it promotes agglomerate fracture and debonding, the increase in energy consumption through fibrillation and crazing promoted by the nanoclay prevails, suggesting that the nanoclay’s toughening effect that has been extensively reported under quasi-static and impact tests, is also present under RCP conditions, and that the HDPE nanocomposites could be used in applications in which RCP must be prevented.
Membrane Nanofiber-Supported Cobalt–Nickel Nanoparticles as an Effective and Durable Catalyst for H2 Evolution via Sodium Borohydride Hydrolysis
Authors: Zouli Nasser , Maafa Ibrahim M. , Abutaleb Ahmed , Yousef Ayman , El-Halwany M. M.
Published: February 2023

The successful support of bimetallic NiCo alloy nanoparticles (NPs) on poly(vinylidene fluoride-co-hexafluoropropylene) nanofibers (PVDF-HFP NFs) was achieved through electrospinning (ES) and in situ reduction. The synthesis and physicochemical characterization of Ni-Co@PVDF-HFP NFs with a range of bimetallic compositions (Ni1−xCox, x = 0, 0.1, 0.3, 0.5, 0.7, 0.9, and 1) supported on PVDF-HFP NFs was undertaken. In comparison to their counterparts (Ni-PVDF-HFB and Co-PVDF-HFB), the bimetallic hybrid NF membranes demonstrated a significantly increased volume of H2 generation from sodium borohydride (SBH). The high performance of bimetallic catalysts can be attributed mostly to the synergistic impact of Ni and Co. Among all fabricated catalysts, Ni0.3Co0.7@PVDF-HFP produced the highest H2 production in a short time. The maximum generated H2volume was 118 mL in 11.5, 9, 6, and 4.5 min at 298, 308, 318, and 328 K, respectively. Kinetic analyses showed that the hydrolysis process proceeded as a quasi-first-order reaction with respect to the amount of catalyst and as a zero-order reaction with respect to the concentration of SBH. Thermodynamics studies were also undertaken and the parameters were calculated as Ea, ΔS, and ΔH = 30.17 kJ/mol, 0.065 kJ/mol, and 27.57 kJ/mol K, respectively. The introduced NFs can be easily separated and reused, which facilitates their industrialization and commercialization applications in hydrogen storage systems.
Experiment and Simulation Research on Rock Damage Mechanism in Tooth Indentation
Authors: Qi Qingliang , Yang Yingxin , Niu Shiwei , Chen Lian , Chen Xu
Published: February 2023

In the oil and gas drilling industry, cemented carbide teeth are one of the most widely used rock-breaking elements. In order to reveal the rock damage mechanism of tooth indentation, a series of tooth indentation experiments were conducted in this study, and an indentation simulation was also conducted as a supplement to the experiment. In the experiment, a new method to observe the inner damage status of the rock was put forward, i.e., utilizing the splitting action of the teeth to avoid unexpected rock damage that may affect the actual experiment results. The load-displacement curves and the damage status of the rock revealed that the wedge tooth was more efficient in fracturing and damaging the rock because the load requirement of the wedge tooth was lower, the narrow tooth crown generated larger specific stress in the rock; that rock-breaking advantage of the wedge tooth resulted from the occurrence of the compacted core and the tension stress generated by the core. According to the simulation results, the plastic strain in the intermediate area between the wedge teeth appeared more concentrated and increased faster, and the rock material beneath the wedge teeth was removed earlier than beneath the conical teeth, indicating that wedge teeth, disposed with proper spacing, can break rock more effectively than the conical teeth. The experiment and simulation results in this paper have proved the advantages of the wedge tooth in rock fracturing and damaging, which will provide technical support for the design and development for the drill bits applied in oil and gas drilling.
Enhancing Mean-Variance Mapping Optimization Using Opposite Gradient Method and Interior Point Method for Real Parameter Optimization Problems
Authors: Saenphon Thirachit , Phimoltares Suphakant , Lursinsap Chidchanok
Published: February 2023

The aim of optimization methods is to identify the best results in the search area. In this research, we focused on a mixture of the interior point method, opposite gradient method, and mean-variance mapping optimization, named IPOG-MVMO, where the solutions can be obtained from the gradient field of the cost function on the constraint manifold. The process was divided into three main phases. In the first phase, the interior point method was applied for local searching. Secondly, the opposite gradient method was used to generate a population of candidate solutions. The last phase involved updating the population according to the mean and variance of the solutions. In the experiments on real parameter optimization problems, three types of functions, which were unimodal, multimodal, and continuous composition functions, were considered and used to compare our proposed method with other meta-heuristics techniques. The results showed that our proposed algorithms outperformed other algorithms in terms of finding the optimal solution.
Grid-Connected Microbial Fuel Cell Modeling and Control in Distributed Generation
Authors: Jiang Fangmei , Fan Liping , Zhang Weimin , Yang Naitao
Published: February 2023

Water shortages and water pollution have seriously threatened the sustainable development of the community. The grid-connected microbial fuel cell is an effective way to control the cost of wastewater treatment plants. Moreover, it solves the problem of low efficiency and high energy consumption. In view of the characteristics of strong coupling, non-linearity, and internal load in the process of microbial fuel cell grid connection, it is necessary to design the grid-connected unit of power electronic device. Based on the establishment of the microbial fuel cell stack model, the stability control and the constant power control scheme were designed for the chopper and inverter, respectively. The simulation results showed that the control strategy with the combination of voltage stabilizer and constant power can make a grid-connected system of all phase voltage and frequency output. The three-phase voltage Uabc was steady at 7 h and the voltage amplitude was controlled at roughly 380 V, according to the output voltage waveform. The value was 50 Hz, which satisfies the criteria for grid connection.
Research on Floor Heave Mechanisms and Control Technology for Deep Dynamic Pressure Roadways
Authors: Zhu Lei , Liu Chengyong , Gu Wenzhe , Yuan Chaofeng , Wu Yuyi , Liu Zhicheng , Song Tianqi , Sheng Fengtian
Published: February 2023

In order to study the influencing factors of floor deformation and floor heave mechanisms of deep mining roadways, this paper takes the deep dynamic pressure mining roadway of a mine as the engineering background and adopts a research method combining theoretical analyses, numerical simulations and field observations to study the influence of various factors on floor deformation and floor heave mechanisms. It is determined that the influencing factors on floor heave are a large buried depth, a long duration of dynamic pressure, unique characteristics of the surrounding rock and an insufficient support strength. A bearing mechanics model of the roadway floor beam is established, and it is determined that the displacement of the roadway floor is negatively correlated with the elastic modulus and floor thickness and positively correlated with the buried depth of roadway, the roadway width and the width of fracture zone. A numerical simulation method is used to study the influence of the original geological conditions, strengthening the elastic modulus of floor, strengthening the strength of the side wall rock and increasing the thickness of the floor rock on the displacement of the roadway floor. It is determined that increasing the thickness of floor rock controls the floor heave the most, followed by strengthening the elastic modulus of the floor rock and then strengthening the strength of the side walls. The results of the numerical simulation agree well with those of the theoretical analysis. After the control method of “bottom lifting + bottom angle bolt + floor bolt ” is adopted on site to treat the floor heave, the floor heave volume of the roadway is small during the service period of the 303 working face return air roadway, which meets the application requirements of the roadway. Meanwhile, the theoretical analysis and numerical simulation results are indirectly verified.
Analysis of Natural Groundwater Flowing into the Flow Field of In Situ Leaching Mining
Authors: Li Qinci , Li Zhaokun , Xie Tingting , Ding Ye , Gan Nan , Tan Yahui , Zhang Chong
Published: February 2023

This paper aims to quantitatively analyze the influence of natural groundwater flowing into the flow field of in situ leaching mining. The computational method was built to evaluate the effect of natural groundwater on the production efficiency of pumping wells for the in situ leaching of uranium, and the “flow ratio of groundwater” and related formulas were defined. C1 and C2 mining areas of an in situ leaching uranium mine in Inner Mongolia were taken as an example, and the effect on the “flow ratio of groundwater” when changing the flow quantity of injection wells and the position and length of the filter in the pumping and injection wells were compared. The results show that the variation in the “flow ratio of groundwater” of a whole mining area or a single pumping well in different production stages can be obtained by the neutral solution concentration value from the mining area’s numerical simulation. Regulating the position, length of the filter, and mode of fluid injection in an in situ leaching mine can control the quantity of natural groundwater flowing into the mining area and reduce the fluid exchange between the flow field of in situ leaching uranium mining and natural groundwater.
Evaluation of Dithiocarbamate-Modified Silica for Cisplatin Removal from Water
Authors: Lombana Fraguela Rachel , Ricardo Garcia José Alejandro , Villanueva Tagle Margarita Edelia , Pomares Alfonso Mario Simeón , Cracchiolo Maria , Kovačević Anđela , Tolazzi Marilena , Melchior Andrea , Sanadar Martina
Published: February 2023

Despite the globally increasing use of platinum-based cytostatic drugs in the treatment of several types of cancer, only limited attention has been paid to developing a treatment for contaminated liquid samples originating from hospitals, laboratories and manufacturing facilities before and after their administration. In this work, we assess the efficiency of a low-cost adsorbent material, a dithiocarbamate-functionalized silica, in removing cisplatin from a solution containing it in the 0.5–150 mg L−1 concentration range. The advantage of having a surface-functionalized silica is that adsorption can occur by either non-covalent interaction or surface complexation. In the latter case platinum(II) is de-complexed and the original drug is no longer present. Adsorption occurs through a first rapid step, followed by a second slower process. This is likely due to the fact that in our operating conditions (0.9% w/v NaCl), only the original compound is present, for which ligand substitution is known to proceed slowly. The interesting performance, even at low metal concentration, and facile synthesis of the material mean it could be adapted for other applications where the recycling of platinum can be realized.
Stability of Combined Continuous Granulation and Agglomeration Processes in a Fluidized Bed with Sieve-Mill-Recycle
Authors: Otto Eric , Dürr Robert , Kienle Achim
Published: February 2023

Particle formation in fluidized beds is widely applied in an industrial context for the solidification of liquids and size enlargement of granular materials. The two main size-enlargement mechanisms are layering growth and agglomeration. For continuous process configurations with sieve-mill-recycle and layering growth only, the occurrence of undesired self-sustained oscillations in the particle size distribution under certain process conditions is well-known. This contribution investigates the stability of the practically relevant process with additional particle agglomeration by means of a model-based numerical bifurcation analysis. It is shown that the occurrence of stable limit cycles is inhibited by an increased rate of particle agglomeration for a variety of different process conditions and different agglomeration kinetics. These results enhance the understanding of the agglomeration and layering growth dynamics and are relevant for the process design and operation.
Research on Motor Rotor Loss of High-Speed Air Compressor in the Application of Hydrogen Fuel Cell Vehicle
Authors: Yu Bo , Wang Fei , Liu Hua , Zhang Zhiping , Chen Yuhui
Published: February 2023

As an important component of hydrogen fuel cell vehicles, the air compressor with an air foil bearing rotates at tens of thousands of revolutions per minute. The heat generation concentration problem caused by the high-speed motor loss seriously affects the safe and normal operation of the motor, so it is very important to clarify the loss distribution of the high-speed motor and adopt a targeted loss reduction design for air compressor heat dissipation. In this paper, for an air compressor with a foil bearing with a rated speed of 80,000 rpm, an empirical formula and a three-dimensional transient magnetic field finite element model are used to model and calculate the air friction loss, stator core loss, winding loss and permanent magnet eddy current loss. The accuracy of the analytical calculation method is verified by torque test experiments under different revolutions, and the average simulation accuracy can reach 91.1%. Then, the distribution of the air friction loss, stator core loss, winding loss and eddy current loss of the air compressor motor at different revolutions is obtained by using this method. The results show that the proposed method can effectively calculate the motor rotor loss of a high-speed air compressor with air foil bearing. Although the motor efficiency increases with the increase in motor speed, the absolute value of loss also increases with the increase in motor speed. Stator core loss and air friction loss are the main sources of loss, accounting for 55.64% and 29% of the total motor loss, respectively. The electromagnetic loss of winding, the eddy current and other alloys account for a relatively small proportion, which is 15% in total. The conclusions obtained in this paper can effectively guide calculations of motor loss the motor heat dissipation design of a high-speed air compressor with an air foil bearing.
Numerical Modeling for Rapid Charging of Hydrogen Gas Vessel in Fuel Cell Vehicle
Authors: Yuan Kaifeng , Pan Hao , Liu Zhan , Andersson Martin
Published: February 2023

As a fuel for power generation, high-pressure hydrogen gas is widely used for transportation, and its efficient storage promotes the development of fuel cell vehicles (FCVs). However, as the filling process takes such a short time, the maximum temperature in the storage tank usually undergoes a rapid increase, which has become a thorny problem and poses great technical challenges to the steady operation of hydrogen FCVs. For security reasons, SAE J2601/ISO 15869 regulates a maximum temperature limit of 85 °C in the specifications for refillable hydrogen tanks. In this paper, a two-dimensional axisymmetric and a three-dimensional numerical model for fast charging of Type III, 35 MPa, and 70 MPa hydrogen vehicle cylinders are proposed in order to effectively evaluate the temperature rise within vehicle tanks. A modified standard k-ε turbulence model is utilized to simulate hydrogen gas charging. The equation of state for hydrogen gas is adopted with the thermodynamic properties taken from the National Institute of Standards and Technology (NIST) database, taking into account the impact of hydrogen gas’ compressibility. To validate the numerical model, three groups of hydrogen rapid refueling experimental data are chosen. After a detailed comparison, it is found that the simulated results calculated by the developed numerical model are in good agreement with the experimental results, with average temperature differences at the end time of 2.56 K, 4.08 K, and 4.3 K. The present study provides a foundation for in-depth investigations on the structural mechanics analysis of hydrogen gas vessels during fast refueling and may supply some technical guidance on the design of charging experiments.
In Silico Prediction, Characterization and Molecular Docking Studies on New Benzamide Derivatives
Authors: Roman Roxana , Pintilie Lucia , Nuță Diana , Avram Speranța , Buiu Catalin , Sogor Catalina , Limban Carmen
Published: February 2023

Recent research papers have confirmed the prevalence of microorganisms resistant to numerous antimicrobial agents, leading to spreading infections, extended hospitalizations, and increased mortality rates. The amplifying factors stimulate the need to discover new molecules able to cut off the developing resistance of pathogens against medicines. The current study presents a molecular docking procedure applied on 15 new pyridine–thiourea derivatives in order to test their activities against S. aureus and E. coli. The protein crystal structures were obtained from the Protein Data Bank (PDB). Processes such as geometry optimization, molecular properties (log P, polarizability, E HOMO, E LUMO, area and volume of the molecules, and ovality), drug-likeness, pharmacokinetic and pharmacogenomic profiles, and molecular docking studies are discussed in the present research. The approach involved the determination of the molecular properties for each chemical structure by using the Spartan 14 software, followed by the evaluation of their binding affinity through a specific docking score with the aid of the CLC Drug Discovery Workbench. Each studied compound established hydrogen bonds with the selected receptors, leading to suitable docking scores and increasing the chances of the compound being considered for further investigation.
An Intelligent Early Flood Forecasting and Prediction Leveraging Machine and Deep Learning Algorithms with Advanced Alert System
Authors: Hayder Israa M. , Al-Amiedy Taief Alaa , Ghaban Wad , Saeed Faisal , Nasser Maged , Al-Ali Ghazwan Abdulnabi , Younis Hussain A.
Published: February 2023

Flood disasters are a natural occurrence around the world, resulting in numerous casualties. It is vital to develop an accurate flood forecasting and prediction model in order to curb damages and limit the number of victims. Water resource allocation, management, planning, flood warning and forecasting, and flood damage mitigation all benefit from rain forecasting. Prior to recent decades’ worth of research, this domain demonstrated to be promising prospects in time series prediction tasks. Therefore, the main aim of this study is to build a forecasting model based on the exponential smoothing-long-short term memory (ES-LSTM) structure and recurrent neural networks (RNNs) for predicting hourly precipitation seasons; and classify the precipitation using an artificial neural network (ANN) model and decision tree (DT) algorithm. We employ the dataset from the Australian commonwealth office of meteorology named Historical Daily Weather dataset to test the effectiveness of the proposed model. The findings showed that the ES-LSTM and RNN had achieved 3.17 and 6.42 in terms of mean absolute percentage error (MAPE), respectively. Meanwhile, the ANN and DT models obtained a prediction accuracy rate of 96.65% and 84.0%, respectively. Finally, the outcomes revealed that ES-LSTM and ANN had achieved the best results compared to other models.
Impact of Non-Saccharomyces Yeast Fermentation in Madeira Wine Chemical Composition
Authors: Miranda Andreia , Pereira Vanda , Jardim Humberto , Malfeito-Ferreira Manuel , Marques José Carlos
Published: February 2023

Madeira wine is produced via spontaneous alcoholic fermentation arrested by ethanol addition. The increasing demand of the wine market has led to the need to standardize the winemaking process. This study focuses on identifying the microbiota of indigenous yeasts present during Madeira wine fermentation and then evaluates the impact of selected indigenous non-Saccharomyces as pure starter culture (Hanseniaspora uvarum, Starmerella bacillaris, Pichia terricola, Pichia fermentans, and Pichia kluyveri) in the chemical and phenolic characterization of Madeira wine production. Results showed that the polyphenol content of the wines was influenced by yeast species, with higher levels found in wines produced by Pichia spp. (ranging from 356.85 to 367.68 mg GAE/L in total polyphenols and 50.52 to 51.50 mg/L in total individual polyphenols through HPLC methods). Antioxidant potential was higher in wines produced with Hanseniaspora uvarum (133.60 mg Trolox/L) and Starmerella bacillaris (137.61 mg Trolox/L). Additionally, Starmerella bacillaris stands out due to its sugar consumption during fermentation (the totality of fructose and 43% of glucose) and 15.80 g/L of total organic acids compared to 9.23 g/L (on average) for the other yeasts. This knowledge can be advantageous to standardizing the winemaking process and increasing the bioactive compounds, resulting in the production of high-quality wines.
A Turbulent Mass Diffusivity Model for Predicting Species Concentration Distribution in the Biodegradation of Phenol Wastewater in an Airlift Reactor
Authors: Li Liang , Hao Runqiu , Jin Xiaoxia , Hao Yachao , Fu Chunming , Zhang Chengkai , Gu Xihui
Published: February 2023

In this study, a three-dimensional CFD transient model is established for predicting species concentration distribution in the biodegradation of phenol in an airlift reactor (ALR). The gas–liquid flow in the ALR is determined by the Euler–Euler method coupled with the standard k-ε model, and the bubble size is predicted by the population balance model (PBM). A turbulent mass diffusivity model is developed to simulate the turbulent mass transfer process and to predict the species concentration distribution. No empirical methods are needed as the turbulent mass diffusivity can be expressed by the concentration variance c2¯ and its dissipation rate εc. A good agreement is found between simulated and experimental results in the literature. It is not reasonable to assume a constant turbulent Schmidt number because the calculated distribution of turbulent mass diffusivity is not identical to that of turbulent viscosity. Finally, the hydrodynamic characteristics and biodegradation performance of the proposed model in a novel ALR are compared with that in the original ALR.