bluuebunny/crossref_metadata_2025 huggingface dataset:
The promise of machine learning in predicting treatment outcomes in psychiatry
Authors: Chekroud Adam M. , Bondar Julia , Delgadillo Jaime , Doherty Gavin , Wasil Akash , Fokkema Marjolein , Cohen Zachary , Belgrave Danielle , DeRubeis Robert , Iniesta Raquel , Dwyer Dominic , Choi Karmel
Published: May 2021

For many years, psychiatrists have tried to understand factors involved in response to medications or psychotherapies, in order to personalize their treatment choices. There is now a broad and growing interest in the idea that we can develop models to personalize treatment decisions using new statistical approaches from the field of machine learning and applying them to larger volumes of data. In this pursuit, there has been a paradigm shift away from experimental studies to confirm or refute specific hypotheses towards a focus on the overall explanatory power of a predictive model when tested on new, unseen datasets. In this paper, we review key studies using machine learning to predict treatment outcomes in psychiatry, ranging from medications and psychotherapies to digital interventions and neurobiological treatments. Next, we focus on some new sources of data that are being used for the development of predictive models based on machine learning, such as electronic health records, smartphone and social media data, and on the potential utility of data from genetics, electrophysiology, neuroimaging and cognitive testing. Finally, we discuss how far the field has come towards implementing prediction tools in real‐world clinical practice. Relatively few retrospective studies to‐date include appropriate external validation procedures, and there are even fewer prospective studies testing the clinical feasibility and effectiveness of predictive models. Applications of machine learning in psychiatry face some of the same ethical challenges posed by these techniques in other areas of medicine or computer science, which we discuss here. In short, machine learning is a nascent but important approach to improve the effectiveness of mental health care, and several prospective clinical studies suggest that it may be working already.
The Central Bank as Lender of Last Resort
Authors: Bindseil Ulrich , Fotia Alessio
Published: May 2021

In this chapter we review the function of the central bank as lender of last resort (LOLR), starting from the understanding of financial crises developed in the previous chapter. We recall long-established LOLR principles: proactive lending, inertia of the central bank risk control framework, and risk endogeneity. Because of its systemic role, a central bank should not tighten its collateral framework in a crisis, as restrictive policies are likely to not only increase the overall damage done by a crisis to society, but to even increase central bank losses. We explain in more detail the main reasons why a central bank should act as LOLR: prevent negative externalities from fire sales; its unique status as institution with unlimited liquidity; its status as a risk-free counterparty making others accept to deliver collateral to it even at high haircuts; and its mandate to preserve price stability. We distinguish three different forms of LOLR: elements built into the regular operational framework; readiness to relax parameters in a crisis; and provision of emergency liquidity assistance to individual firms. We then discuss what could be the optimal propensity of a central bank to engage in LOLR activities and outline possible trade-offs. Last but not least, we develop a bank-run model which highlights the role of asset liquidity and central bank eligible collateral. We calculate through a model variant with binary asset liquidity and uniform central bank collateral haircut, but then also introduce a model variant with continuous asset liquidity and haircuts.
Threatening – The Refugee as a Threat
Authors: Massari Alice
Published: May 2021

Contemporary media and public accounts have increasingly framed the refugee ‘crisis’ in terms of security, with refugees considered as masses to be managed and controlled, migrants pointed at with generic allegation of terrorist threat, and state borders closed and militarized. Securitization of migration may not be a new phenomenon (Saunders 2014) but it is one that has recently received a great deal of attention (see among others Bigo 2002; Pugh 2004; Huysmans and Squire 2009; Huysmans 2000; Musarò 2017; Vaughan-Williams 2015; Watson 2009). What all these scholars have in common is that they highlight different ways through which refugees are represented, described, and thought of asthreat. Media and public accounts have consistently represented refugees through words such as plight, invasion, flood, hordes, or waves (Friese 2017). The “highly heterogeneous and (too) strongly mediation-dependent European politics created an array of – in most cases negative – interpretations of the Refugee Crisis” (Krzyżanowski et al. 2018). In line with this narrative, at the visual level, the images that have accompanied the news on refugees have mostly included overcrowded boats, long lines of people in need, and looming masses of people crammed at border fences.
Threatened, the Refugee as the Referent Object
Authors: Massari Alice
Published: May 2021

Since its inception, humanitarian communication has consistently represented beneficiaries as referent objects of a threat, as threatened. Images of victims, whether in the traditional representation of a sea of humanity’ (Malkki 1996) or in the more recent aesthetic style of the individual portrait, have consistently constituted the large bulk of humanitarian NGOs’ visual production. This chapter focuses on the representation of Syrian refugees as ‘threatened’ to show how this depiction of refugees is just another form of securitization, whereby Syrians are depicted as infantilized and passive victims in need of external intervention. In order to do so, it is worthwhile digressing to understand how remarkable have been the structural changes that humanitarianism has undergone over the last quarter century and how new relief assistance’ modalities, while seeking to putting individuals and their rights center stage have also primarily represented them in terms of victimhood.
The network origins of Schumpeterian innovation
Authors: Pammolli Fabio , Riccaboni Massimo , Spelta Alessandro
Published: May 2021

This paper investigates the key driving features of the evolving long-term division of innovative labor in biotechnology and pharmaceuticals from 1981 to 2012. Our main goal is to find if technological trajectories and mechanisms discovered by Orsenigo et al. (Res Policy 30(3): 485–508, 2001) as the main drivers of the structural configuration of the network of collaborative alliances have been at work in the long-term evolution of the industry. We extensively analyze the evolving dynamics of the degree distribution and the higher order properties of the R&D network. As in Orsenigo et al. (Res Policy 30(3): 485–508, 2001), we find that polarization through preferential attachment driven by large pharmaceutical companies as Developers and by the entry of new specialized biotechnology companies acting as Originators of new R&D opportunities dominated the early stages of the biotechnology revolution. Later on the evolution of the collaborative network has been shaped by roles’ transitions between Originators and Developers of innovative ideas. Against this background, we introduce parsimonious model of network formation and evolution is introduced, to account for some essential features of the data generating processes underlying the evolution of the network.
Nutzung von Altersinformationen aus posttranslationalen Proteinmodifikationen und DNA-Methylierung zur postmortalen Lebensaltersschätzung
Authors: Becker Julia , Naue Jana , Reckert Alexandra , Böhme Petra , Ritz-Timme Stefanie
Published: May 2021

Mit der Identifikation und Beschreibung „molekularer Uhren“ (posttranslationale Proteinmodifikationen, DNA-Methylierung) eröffnen sich neue Möglichkeiten zur Entwicklung von Verfahren zur postmortalen Lebensaltersschätzung. Bislang werden diese Ansätze aber nur unabhängig voneinander eingesetzt. Ihre Verknüpfung verspricht eine bessere Erfassung hochkomplexer Alterungsprozesse und damit die Möglichkeit zur Entwicklung optimierter Verfahren zur Altersschätzung für verschiedenste Szenarien der forensischen Praxis.

In Vorbereitung umfangreicher Untersuchungen zur Überprüfung dieser Hypothese wurden verschiedene molekulare Uhren (Akkumulation von D‑Asparaginsäure, Akkumulation von Pentosidin und DNA-Methylierungsmarker [RPA2, ZYG11A, F5, HOXC4, NKIRAS2, TRIM59, ELOVL2, DDO, KLF14 und PDE4C]) in 4 fäulnisresistenten Geweben (Knochen, Sehne, Bandscheibe, Epiglottis) von 15 Individuen untersucht.

In allen untersuchten Geweben fand sich eine starke Korrelation beider Proteinmarker sowie jeweils mehrerer DNA-Methylierungsmarker mit dem Lebensalter. Dabei zeigten die untersuchten Parameter gewebsspezifische Veränderungen mit dem Alter.

Die Ergebnisse der Pilotstudie belegen das Potenzial der Verknüpfung molekularer Verfahren für die postmortale Altersschätzung. Weitere Untersuchungen werden zeigen, wie genau postmortale Altersschätzungen sein können, wenn Altersinformationen aus posttranslationalen Proteinmodifikationen und DNA-Methylierung aus verschiedenen Geweben in multivariaten Modellen verknüpft werden.
Diabatic potential energy curves for the $$^4{\Pi} $$ states of SH
Authors: Kashinski D. O. , Bohnemann J. , Hickman A. P. , Talbi D.
Published: May 2021

We present a diabatic representation of the potential energy curves (PECs) for the $$^4{{\Pi}} $$

4

Π

states of $$\mathrm {SH}$$
SH
. Multireference, configuration interaction (MRCI) calculations were used to determine high-accuracy adiabatic PECs of both $$\mathrm {SH}$$
SH
and $${\mathrm {SH}}^+$$

SH

+

from which the diabatic representation is constructed for $$\mathrm {SH}$$
SH
. The adiabatic PECs exhibit many avoided crossings due to strong Rydberg-valence mixing. We employ the block diagonalization method, an orthonormal rotation of the adiabatic Hamiltonian, to disentangle the valence autoionizing and Rydberg $$^4\Pi $$

4

Π

states of $$\mathrm {SH}$$
SH
by constructing a diabatic Hamiltonian. The diagonal elements of the diabatic Hamiltonian matrix at each nuclear geometry render the diabatic PECs and the off-diagonal elements are related to the state-to-state coupling. Care is taken to assure smooth variation and consistency of chemically significant molecular orbitals across the entire geometry domain.
Diagnosis and Management of Osteoporosis During COVID-19: Systematic Review and Practical Guidance
Authors: Hampson G. , Stone M. , Lindsay J. R. , Crowley R. K. , Ralston S. H.
Published: May 2021

It is acknowledged that the COVID-19 pandemic has caused profound disruption to the delivery of healthcare services globally. This has affected the management of many long-term conditions including osteoporosis as resources are diverted to cover urgent care. Osteoporosis is a public health concern worldwide and treatment is required for the prevention of further bone loss, deterioration of skeletal micro-architecture, and fragility fractures. This review provides information on how the COVID-19 pandemic has impacted the diagnosis and management of osteoporosis. We also provide clinical recommendations on the adaptation of care pathways based on experience from five referral centres to ensure that patients with osteoporosis are still treated and to reduce the risk of fractures both for the individual patient and on a societal basis. We address the use of the FRAX tool for risk stratification and initiation of osteoporosis treatment and discuss the potential adaptations to treatment pathways in view of limitations on the availability of DXA. We focus on the issues surrounding initiation and maintenance of treatment for patients on parenteral therapies such as zoledronate, denosumab, teriparatide, and romosozumab during the pandemic. The design of these innovative care pathways for the management of patients with osteoporosis may also provide a platform for future improvement to osteoporosis services when routine clinical care resumes.
Diurnal Salivary Cortisol in Sarcopenic Postmenopausal Women: The OsteoLaus Cohort
Authors: Gonzalez Rodriguez Elena , Marques-Vidal Pedro , Aubry-Rozier Bérengère , Papadakis Georgios , Preisig Martin , Kuehner Christine , Vollenweider Peter , Waeber Gerard , Hans Didier , Lamy Olivier
Published: May 2021

Sarcopenia, similar to hypercortisolism, is characterized by loss of muscle mass and strength. Cortisol circadian rhythm changes with aging (blunted late-day nadir values) were suggested to contribute to this decline. We aimed to explore the relationship between diurnal salivary cortisol values and sarcopenia diagnosis and its components in postmenopausal women. This is a cross-sectional study within the OsteoLaus population-based cohort in Lausanne (Switzerland). Participants had a body composition assessment by dual X-ray absorptiometry (DXA), a grip strength (GS) measure, and salivary cortisol measures (at awakening, 30 min thereafter, 11 AM (sc-11AM) and 8 PM (sc-8PM)). Associations between salivary cortisol and sarcopenia diagnosed by six different criteria (based on appendicular lean mass (ALM) assessed by DXA, and muscle strength by GS), and its components, were analyzed. 471 women aged > 50 years (63.0 ± 7.5) were included. Various definitions identified different participants as sarcopenic, who consistently presented higher salivary cortisol at 11 AM and/or 8 PM. There were no associations between salivary cortisol levels and ALM measures, either absolute or after correction to height squared (ALM index) or body mass index. GS was inversely correlated to sc-11AM (r = − 0.153, p < 0.001) and sc-8PM (r = − 0.118, p = 0.002). Each 10 nmol/l increase of sc-11AM, respectively sc-8PM, was associated with a GS decrease of 1.758 (SE 0.472) kg, respectively 2.929 (SE 1.115) kg. In postmenopausal women, sarcopenia is associated with higher salivary cortisol levels at 11 AM and 8 PM. An increase of daily free cortisol levels in the physiological range could participate to sarcopenia development by decreasing muscle function in postmenopausal women.
Improved diagnostic accuracy for ulnar-sided TFCC lesions with radial reformation of 3D sequences in wrist MR arthrography
Authors: Huflage Henner , Luetkens Karsten Sebastian , Kunz Andreas Steven , Conrads Nora , Jakubietz Rafael Gregor , Jakubietz Michael Georg , Pennig Lenhard , Goertz Lukas , Bley Thorsten Alexander , Schmitt Rainer , Grunz Jan-Peter
Published: May 2021

Objectives

Triangular fibrocartilage complex (TFCC) injuries frequently cause ulnar-sided wrist pain and can induce distal radioulnar joint instability. With its complex three-dimensional structure, diagnosis of TFCC lesions remains a challenging task even in MR arthrograms. The aim of this study was to assess the added diagnostic value of radial reformatting of isotropic 3D MRI datasets compared to standard planes after direct arthrography of the wrist.

Methods

Ninety-three patients underwent wrist MRI after fluoroscopy-guided multi-compartment arthrography. Two radiologists collectively analyzed two datasets of each MR arthrogram for TFCC injuries, with one set containing standard reconstructions of a 3D thin-slice sequence in axial, coronal and sagittal orientation, while the other set comprised an additional radial plane view with the rotating center positioned at the ulnar styloid. Surgical reports (whenever available) or radiological reports combined with clinical follow-up served as a standard of reference. In addition, diagnostic confidence and assessability of the central disc and ulnar-sided insertions were subjectively evaluated.

Results

Injuries of the articular disc, styloid and foveal ulnar attachment were present in 20 (23.7%), 10 (10.8%) and 9 (9.7%) patients. Additional radial planes increased diagnostic accuracy for lesions of the styloid (0.83 vs. 0.90; p = 0.016) and foveal (0.86 vs. 0.94; p = 0.039) insertion, whereas no improvement was identified for alterations of the central cartilage disc. Readers’ confidence (p < 0.001) and assessability of the ulnar-sided insertions (p < 0.001) were superior with ancillary radial reformatting.

Conclusions

Access to the radial plane view of isotropic 3D sequences in MR arthrography improves diagnostic accuracy and confidence for ulnar-sided TFCC lesions.

Key Points

• In multi-compartment arthrography of the wrist, ancillary radial plane view aids assessability of the foveal and styloid ulnar-sided insertions of the triangular fibrocartilage complex.

• Assessment of peripheral TFCC injuries is more accurate with access to radial multiplanar reconstructions.

• Additional radial planes provide greater diagnostic confidence.
Palynological evidence from a sub-alpine marsh of enhanced Little Ice Age snowpack in the Marrakech High Atlas, North Africa
Authors: Bell Benjamin A. , Fletcher William J. , Hughes Philip D. , Cornelissen Henk L. , Fink David , Rhoujjati Ali
Published: May 2021

The grazing lands of the High Atlas are vulnerable to climate change and the decline of traditional management practices. However, prior to the mid-20th century, there is little information to examine historical environmental change and resilience to past climate variability. Here, we present a new pollen, non-pollen palynomorph (NPP) and microcharcoal record from a sub-alpine marsh (pozzine) at Oukaïmeden, located in the Marrakech High Atlas, Morocco. The record reveals a history of grazing impacts with diverse non-arboreal pollen assemblages dominant throughout the record as well as recurrent shifts between wetter and drier conditions. A large suite of radiocarbon dates (n = 22) constrains the deposit to the last ~ 1,000 years although multiple reversed ages preclude development of a robust age-depth model for all intervals. Between relatively dry conditions during the Medieval period and in the 20th century, intervening wet conditions are observed, which we interpret as a locally enhanced snowpack during the Little Ice Age. Hydrological fluctuations evidenced by wetland pollen and NPPs are possibly associated with centennial-scale precipitation variability evidenced in regional speleothem records. The pollen record reveals an herbaceous grassland flora resilient against climatic fluctuations through the last millennium, possibly supported by sustainable collective management practices (agdal), with grazing indicators suggesting a flourishing pastoral economy. However, during the 20th century, floristic changes and increases in charcoal accumulation point to a decline in management practices, diversification of land-use (including afforestation) and intensification of human activity.
Pediatric ependymoma: an overview of a complex disease
Authors: Jünger Stephanie Theresa , Timmermann Beate , Pietsch Torsten
Published: May 2021

Pediatric ependymomas comprise biologically distinct tumor entities with different (epi)genetics, age distribution and localization, as well as a different prognosis. Regarding risk stratification within these biologically defined entities, histopathological features still seem to be relevant. The mainstay of treatment is gross total resection (GTR) if possible, achieved with intraoperative monitoring and neuronavigation—and if necessary second surgery—followed by adjuvant radiation therapy. However, there is growing evidence that some ependymal tumors may be cured by surgery alone, while others relapse despite adjuvant treatment. To date, the role of chemotherapy is not clear. Current therapy achieves reasonable survival rates for the majority of ependymoma patients. The next challenge is to go beyond initial tumor control and use risk-adapted therapy to reduce secondary effect and therapy-induced morbidity for low-risk patients and to intensify treatment for high-risk patients. With identification of specific alterations, targeted therapy may represent an option for individualized treatment modalities in the future.
Brainstem neuropathology in two cases of COVID-19: SARS-CoV-2 trafficking between brain and lung
Authors: Bulfamante Gaetano , Bocci Tommaso , Falleni Monica , Campiglio Laura , Coppola Silvia , Tosi Delfina , Chiumello Davide , Priori Alberto
Published: May 2021

Introduction

SARS-CoV-2 might spread through the nervous system, reaching respiratory centers in the brainstem. Because we recently reported neurophysiological brainstem reflex abnormalities in COVID-19 patients, we here neuropathologically assessed structural brainstem damage in two COVID-19 patients.

Materials and methods

We assessed neuropathological features in two patients who died of COVID-19 and in two COVID-19 negative patients as controls. Neuronal damage and corpora amylacea (CA) numbers /mm2 were histopathologically assessed. Other features studied were the immunohistochemical expression of the SARS-CoV-2 nucleoprotein (NP) and the Iba-1 antigen for glial activation.

Results

Autopsies showed normal gross brainstem anatomy. Histopathological examination demonstrated increased neuronal and CA damage in Covid-19 patients’ medulla oblongata. Immunohistochemistry disclosed SARS-CoV-2 NP in brainstem neurons and glial cells, and in cranial nerves. Glial elements also exhibited a widespread increase in Iba-1 expression. Sars-Co-V2 was immunohistochemically detected in the vagus nerve fibers.

Discussion

Neuropathologic evidence showing SARS-CoV-2 in the brainstem and medullary damage in the area of respiratory centers strongly suggests that the pathophysiology of COVID-19-related respiratory failure includes a neurogenic component. Sars-Co-V2 detection in the vagus nerve, argues for viral trafficking between brainstem and lung.
The log odds of negative lymph nodes/T stage: a new prognostic and predictive tool for resected gastric cancer patients
Authors: Xie Jiebin , Pang Yueshan , Li Xun , Wu Xiaoting
Published: May 2021

Purpose

When only the TNM classification is used to predict survival in gastric cancer (GC) patients, the impact of the degree of lymphadenectomy on the prognosis is neglected. This study aimed to establish a more effective nomogram based on the log odds of negative lymph nodes/T stage ratio (LONT) to predict survival in surgically treated GC patients.

Methods

The data of resected GC patients were extracted from the Surveillance, Epidemiology, and End Results Program (SEER) database. Univariate and multivariate Cox regression analyses were used to identify the significant prognostic factors. The prognostic performance was assessed using a calibration plot, concordance index (C-index), and area under the (time-dependent receiver operating characteristic) curve (AUC) to compare the predicted survival probability based on the nomogram score groups.

Results

The results showed LONT as an independent prognostic factor for cancer-specific survival (CSS) and overall survival (OS), independent of clinicopathological factors. After removing potential redundancy, only LONT, T stage, N stage, location and age were used in the final nomogram model. The model had a higher C-index (0.736 ± 0.012) and AUC (0.798) than the TNM staging system (0.685 ± 0.012 and 0.744). The nomogram score could predict a significant survival difference between any two adjacent groups in terms of CSS and OS.

Conclusion

High LONT is associated with improved survival of gastric cancer patients, independent of other clinicopathological factors. The prognostic nomogram model based on LONT could effectively predict CSS and OS for resectable GC patients.
EGFR mutation analysis on circulating free DNA in NSCLC: a single-center experience
Authors: Ianza Anna , Di Chicco A. , Biagi C. , Giudici F. , Dicorato A. , Guglielmi A. , Variola F. , Tomasi S. , Roviello G. , Generali D. , Zanconati F.
Published: May 2021

Purpose

Monitoring mutation status in circulating free DNA (cfDNA) during target therapy could hold significant clinical importance in non-small cell lung cancer (NSCLC). Our aim is to establish if EGFR mutational status change on cfDNA has predictive value that can impact clinical management of NSCLC patients care.

Methods

This study included 30 patients with EGFR-mutated NSCLC. Blood samples were collected at diagnosis (T0) and in 19 patients during therapy (T1).

Results

Concordance between T0 and T1 EGFR mutation status for patients evaluable for both samples (n = 19) was 79%, with a sensitivity of 100% (95% CI: 55.5–100.0) and specificity of 60.0% (95% CI: 26.2–86.8). For the patients in oncological therapy with targeted drug and with T1 sample available (n = 18), survival outcomes were evaluated. For both mutation-negative T0 and T1 patients, 12-month progression-free survival (PFS) was 66.7% (95% CI: 27.2–100.0) and 12-month overall survival (OS) was 100% (95% CI: 1.00–1.00); for patients mutated both at T0 and T1, PFS was 22.2% (95% CI: 6.5–75.4%) and OS was 55.6% (95% CI: 20.4–96.1%).

Conclusion

EGFR mutation status can be assessed using cfDNA for routine purposes and longitudinal assessment of plasma mutation is an easy approach to monitor the therapeutic response or resistance onset.
Sexual health and wellbeing after pelvic radiotherapy among women with and without a reported history of sexual abuse: important issues in cancer survivorship care
Authors: Åkeflo Linda , Elmerstig Eva , Dunberger Gail , Skokic Viktor , Arnell Amanda , Bergmark Karin
Published: May 2021

Aims

Sexual abuse is a women’s health concern globally. Although experience of sexual abuse and cancer may constitute risk factors for sexual dysfunction and low wellbeing, the effects of sexual abuse have received little attention in oncology care. This study aims to explore sexual health and wellbeing in women after pelvic radiotherapy and to determine the relationship between sexual abuse and sexual dysfunction, and decreased wellbeing.

Methods

Using a study-specific questionnaire, data were collected during 2011–2017 from women with gynaecological, anal, or rectal cancer treated with curative pelvic radiotherapy in a population-based cohort and a referred patient group. Subgroup analyses of data from women with a reported history of sexual abuse were conducted, comparing socio-demographics, diagnosis, aspects of sexual health and wellbeing.

Results

In the total sample of 570 women, 11% reported a history of sexual abuse and among these women the most common diagnosis was cervical cancer. More women with than without a history of sexual abuse reported feeling depressed (19.4% vs. 9%, p = 0.007) or anxious (22.6% vs. 11.8%, p = 0.007) and suffering genital pain during sexual activity (52% vs. 25.1%, p = 0.011, RR 2.07, CI 1.24–3.16). In the total study cohort, genital pain during sexual activity was associated with vaginal shortness (68.5% vs. 31.4% p ≤ 0.001) and inelasticity (66.6% vs. 33.3%, p ≤ 0.001).

Conclusions

Our findings suggest that a history of both sexual abuse and pelvic radiotherapy in women are associated with increased psychological distress and sexual impairment, challenging healthcare professionals to take action to prevent retraumatisation and provide appropriate interventions and support.
Metabolic surgery for type II diabetes: an update
Authors: Gentileschi Paolo , Bianciardi Emanuela , Benavoli Domenico , Campanelli Michela
Published: May 2021

Bariatric operations have been documented in clinical trials to promote remission or dramatic improvement of Type II Diabetes Mellitus and related comorbidities. Herein we review randomized trials and meta-analyses published during the last 20 years on the results of bariatric/metabolic surgery in obese patients with type 2 diabetes with the aim of highlighting the scientific evidence available. Several studies and RCTs in the last 20 years have showed outstanding results of bariatric/metabolic surgery on Type II diabetes and comorbidities in patients with either BMI > 35 kg/m2 or BMI < 35 kg/m2. They have established that bariatric procedures are superior to non-surgical interventions for inducing weight loss and amelioration of type 2 diabetes, even in patients with a BMI between 30 and 35 kg/m2. The physiopatologic changes that improve glucose homeostasis after bariatric surgery remain unclear but glycemic control is improved after sleeve gastrectomy, duodenal-jejunal bypass, Roux-en-Y gastric bypass, gastric banding, One Anastomosis Gastric Bypass, and biliopancreatic diversion. Nevertheless, it is suggested that the various gastrointestinal procedures may have different effects and mechanisms of action. Metabolic surgery will help integrate knowledge and multidisciplinary expertise to provide a combination of conservative and surgical treatments for Type II diabetes. These treatments must be considered as complementary options and not alternative strategies, with the same goal of controlling diabetes and achieving cure.
Network Structured Kinetic Models of Social Interactions
Authors: Burger Martin
Published: May 2021

The aim of this paper is to study the derivation of appropriate meso- and macroscopic models for interactions as appearing in social processes. There are two main characteristics the models take into account, namely a network structure of interactions, which we treat by an appropriate mesoscopic description, and a different role of interacting agents. The latter differs from interactions treated in classical statistical mechanics in the sense that the agents do not have symmetric roles, but there is rather an active and a passive agent. We will demonstrate how a certain form of kinetic equations can be obtained to describe such interactions at a mesoscopic level and moreover obtain macroscopic models from monokinetics solutions of those. The derivation naturally leads to systems of nonlocal reaction-diffusion equations (or in a suitable limit local versions thereof), which can explain spatial phase separation phenomena found to emerge from the microscopic interactions. We will highlight the approach in three examples, namely the evolution and coarsening of dialects in human language, the construction of social norms, and the spread of an epidemic.
Repaying the Debt: An Examination of the Relationship between Perceived Organizational Support and Unethical Pro-organizational Behavior by Low Performers
Authors: Wang Xiaoyu , Zheng Xiaotong , Zhao Shuming
Published: May 2021

Drawing on social exchange theory, we examine the conditions under which employees’ good intentions motivate them to engage in unethical pro-organizational behavior (UPB) and the psychological mechanism behind this behavioral decision. Findings from a time-lagged field study and a scenario study indicate (1) an interactive effect between perceived organizational support and employee performance on UPB; (2) that low performers who perceive high levels of organizational support are more likely to engage in UPB; and (3) that feelings of indebtedness to the organization mediate the interactive effect on UPB. Therefore, the paper highlights the importance of conditional factors in motivating UPB by combining employee ‘good intentions’ and ‘disadvantageous situations’ to understand the UPB decision process. The paper concludes with theoretical and practical implications.
Trends in Esophageal Cancer Mortality and Stage at Diagnosis by Race and Ethnicity in the United States
Authors: Corona Edgar , Yang Liu , Esrailian Eric , Ghassemi Kevin A. , Conklin Jeffrey L. , May Folasade P.
Published: May 2021

Introduction

Esophageal cancer (EC) is an aggressive malignancy with poor prognosis. Mortality and disease stage at diagnosis are important indicators of improvements in cancer prevention and control. We examined United States trends in esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC) mortality and stage at diagnosis by race and ethnicity.

Methods

We used Surveillance, Epidemiology, and End Results (SEER) data to identify individuals with histologically confirmed EAC and ESCC between 1 January 1992 and 31 December 2016. For both EAC and ESCC, we calculated age-adjusted mortality and the proportion presenting at each stage by race/ethnicity, sex, and year. We then calculated the annual percent change (APC) in each indicator by race/ethnicity and examined changes over time.

Results

The study included 19,257 EAC cases and 15,162 ESCC cases. EAC mortality increased significantly overall and in non-Hispanic Whites from 1993 to 2012 and from 1993 to 2010, respectively. EAC mortality continued to rise among non-Hispanic Blacks (NHB) (APC = 1.60, p = 0.01). NHB experienced the fastest decline in ESCC mortality (APC = − 4.53, p < 0.001) yet maintained the highest mortality at the end of the study period. Proportions of late stage disease increased overall by 18.5 and 24.5 percentage points for EAC and ESCC respectively; trends varied by race/ethnicity.

Conclusion

We found notable differences in trends in EAC and ESCC mortality and stage at diagnosis by race/ethnicity. Stage migration resulting from improvements in diagnosis and treatment may partially explain recent trends in disease stage at diagnosis. Future efforts should identify factors driving current esophageal cancer disparities.
Historical and future drought impacts in the Pacific islands and atolls
Authors: Iese Viliamu , Kiem Anthony S. , Mariner Azarel , Malsale Philip , Tofaeono Tile , Kirono Dewi G.C. , Round Vanessa , Heady Craig , Tigona Robson , Veisa Filipe , Posanau Kisolel , Aiono Faapisa , Haruhiru Alick , Daphne Arieta , Vainikolo Vaiola , Iona Nikotemo
Published: May 2021

Drought is known as a “creeping disaster” because drought impacts are usually noticed months or years after a drought begins. In the Pacific Island Countries and Territories (PICTs), there is almost no ability to tell when a drought will begin or end, especially for droughts other than meteorological droughts. Monitoring, forecasting and managing drought in the PICTs is complex due to the variety of different ways droughts occur, and the diverse direct and indirect causes and consequences of drought, across the PICT region. For example, the impacts of drought across the PICTs vary significantly depending on (i) the type of drought (e.g. meteorological drought or agricultural drought); (ii) the location (e.g. high islands versus atolls); (iii) socioeconomic conditions in the location affected by drought; and (iv) cultural attitudes towards the causes of drought (e.g. a punishment from God versus a natural process that is potentially predictable and something that can be managed). This paper summarises what is known and unknown about drought impacts in the PICTs and provides recommendations to guide future research and investment towards minimising the negative impacts of droughts when they inevitably occur in the PICTs.
“It Often Feels Like You Are Talking to a Wall”: Police and Private Security Responses to the Campaign to Protect Pont Valley Against Opencast Coal Extraction
Authors: Stephens-Griffin Nathan , Lampkin Jack , Wyatt Tanya , Stephenson Carol
Published: May 2021

Conflict between police, private security and political protesters is a topic that has been researched widely in criminology and other disciplines (e.g., Choudry 2019; Gilmore et al. 2019; Goyes and South 2017; Jackson et al. 2018; Rigakos 2002; South 1988; Weiss 1978). Adopting a green criminological lens, this article seeks to contribute to this rich body of research by examining police and private security responses to campaigning against opencast (open-pit) coal mining in Pont Valley, County Durham, United Kingdom (UK). Based on qualitative interviews, the article examines activists’ perceptions of responses to their campaign. Our findings reveal that rather than acting as neutral arbiters, police colluded with private interests, overlooking the abusive behavior of private security and bailiffs, particularly during the eviction of a protest camp at the proposed mining site. Activists believed that their right to protest was not respected, that their safety was jeopardized, and that police had willfully ignored a wildlife crime perpetrated by the mining company in order to enable mining to go ahead. Our article argues that the Pont Valley case fits into a wider pattern of repression of environmentalism in the UK, supporting Gilmore and colleagues’ (2019) argument that a progressive transformation in policing has been overstated.
Technology-mediated teaching and learning process: A conceptual study of educators’ response amidst the Covid-19 pandemic
Authors: Okoye Kingsley , Rodriguez-Tort Jorge Alfonso , Escamilla Jose , Hosseini Samira
Published: May 2021

The COVID-19 pandemic has disrupted many areas of the human and organizational ventures worldwide. This includes new innovative technologies and strategies being developed by educators to foster the rapid learning-recovery and reinstatement of the stakeholders (e.g., teachers and students). Indeed, the main challenge for educators has been on what appropriate steps should be taken to prevent learning loss for the students; ranging from how to provide efficient learning tools/curriculum that ensures continuity of learning, to provision of methods that incorporate coping mechanisms and acceleration of education in general. For several higher educational institutions (HEIs), technology-mediated education has become an integral part of the modern teaching/learning instruction amidst the Covid-19 pandemic, when digital technologies have consequently become an inevitable and indispensable part of learning. To this effect, this study defines a hybrid educational model (HyFlex + Tec) used to enable virtual and in-person education in the HEIs. Practically, the study utilized data usage report from Massive Open Online Courses (MOOCs) and Emotions and Experience Survey questionnaire in a higher education setting for its experiments. To this end, we applied an Exponential Linear trend model and Forecasting method to determine overall progress and statistics for the learners during the Covid-19 pandemic, and subsequently performed a Text Mining and Univariate Analysis of Variance (ANOVA) to determine effects and significant differences that the teaching–learning experiences for the teachers and students have on their energy (learning motivation) levels. From the results, we note that the hybrid learning model supports continuity of education/learning for teachers and students during the Covid-19 pandemic. The study also discusses its innovative importance for future monitoring (tracking) of learning experiences and emotional well-being for the stakeholders in leu (aftermath) of the Covid-19 pandemic.
Understanding firm exit: a systematic literature review
Authors: Cefis Elena , Bettinelli Cristina , Coad Alex , Marsili Orietta
Published: May 2021

We investigate the corpus of literature on firm exit by means of a systematic literature review (SLR) which yields a final sample of 142 journal articles for the period 1991–2020. The phenomenon of firm exit is explored from a variety of perspectives: business exit; exit at the individual entrepreneur level; exit from specific markets; exit from foreign markets; and the role of exit for industrial dynamics conceived more broadly. Special attention is given to the various exit routes, including voluntary liquidation, mergers and acquisitions (M&A), initial public offerings (IPO), and of course bankruptcy. The SLR sets the scene for the Special Issue papers that are presented towards the end, and we conclude with some suggestions for future research.

The Plain English Summary This article develops a systematic literature review around three decades of firm exit research, patterns, developments, and intriguing gaps. In this paper, we systematically review 142 studies on firm exit from various perspectives, identify major patterns, and outline the debate around firm exit. We propose reflections useful for scholars willing to engage in firm exit research in the future and set the scene for the special issue papers. Overall, this work shows the remarkable progress made in the area of firm exit that has evolved from the view of exit as a homogenous event signaling failure to a vision of exit as a heterogenous event. Exploring the sources of heterogeneity of exits from various perspectives could offer promising paths for future research.
T2-mapping MRI evaluation of patellofemoral cartilage in patients submitted to intra-articular platelet-rich plasma (PRP) injections
Authors: Cobianchi Bellisari Flavia , De Marino Luigi , Arrigoni Francesco , Mariani Silvia , Bruno Federico , Palumbo Pierpaolo , De Cataldo Camilla , Sgalambro Ferruccio , Catallo Nadia , Zugaro Luigi , Di Cesare Ernesto , Splendiani Alessandra , Masciocchi Carlo , Giovagnoni Andrea , Barile Antonio
Published: May 2021

This study evaluated the ability of T2 mapping magnetic resonance imaging at 3 T, in addition to morphological sequences, to assess efficacy of platelet-rich plasma (PRP) injections, characterizing qualitatively and quantitatively the grade of knee cartilage repair in patients with patellofemoral chondropathy. We retrospectively studied 34 patients (22 men, 12 women, mean age 41.8 years, including 22 men) with patellofemoral knee chondropathy, who underwent intra-articular PRP injections and completed a clinical and instrumental follow-up. As control group, we evaluated 34 patients who underwent non-operative therapy. All patients were submitted to clinical (using VAS and WOMAC index) and imaging studies with 3 T magnetic resonance with cartilage analysis with T2 mapping sequences for cartilage analysis before and after treatment. In the study group, mean pre-treatment T2 relaxation time values were 44.2 ± 2.5 ms, considering all articular cartilage compartments, with significant reduction at the follow-up (p < 0.001). At the index compartment, mean pre-treatment T2 relaxation times values were 47.8 ± 3.6 ms, with statistically significant reduction at the follow-up (p < 0.001). Evaluation of focal cartilage lesions reported pre-treatment mean T2 value of 70.1 ± 13.0 ms and post-treatment mean value of 59.9 ± 4.6 ms (p < 0.001). From a clinical point of view, the pre-treatment WOMAC and VAS scores were 18.3 ± 4.5 and 7 (IQR:6–7.2), respectively; the post-treatment values were 7.3 ± 3.2 and 2 (IQR: 1.7–3.0), respectively (p < 0.001). In the control group, despite clinical improvement, we didn’t find significant T2 values change during the follow-up period. In conclusion, T2 mapping is a valuable indicator for chondropathy and treatment-related changes over time.
Call the midwife. Health personnel and mortality in Norway 1887–1920
Authors: Kotsadam Andreas , Lind Jo Thori , Modalsli Jørgen
Published: May 2021

At the turn of the twentieth century, Norway, like many other countries, experienced a decrease in mortality and a substantial increase in the number of health personnel. In order to assess how these changes were connected, we investigate the relationship between health personnel and mortality using data at the medical district level ($$N=106$$

N
=
106

) covering a period of 34 years. We find a large and robust effect of midwives on reduced maternal mortality in rural areas, but no effect in urban areas. No clear effect is found for other types of health personnel or on infant mortality. The results demonstrate the important role played by public health investments during the period.
Connections between trades and trafficking in wildlife and drugs
Authors: van Uhm Daan , South Nigel , Wyatt Tanya
Published: May 2021

Whilst drug trafficking has been a concern for several decades, wildlife trafficking has only fairly recently garnered international attention. Often media coverage of wildlife trafficking links it to the illegal trade of drugs. This article analyses wildlife and drug trafficking connections of various kinds. The purpose is to reveal the overlaps and synergies of wildlife and drug trafficking, providing concrete examples of where these markets co-exist as well as intertwine based on literature and original fieldwork. It explores the question of ‘Why in some cases, an illicit market remains focused on a single commodity, whilst in others it accommodates a combination of illicit commodities?’ This study identifies different types of wildlife-drugs linkages, including combined contraband, camouflage, multiple trade lines, shared smuggling routes and transportation methods, barter trade, and laundering drug money. The article shows that illicit markets are complex and the examples of activities and transactions that are provided illuminate some of the different dimensions of converging and diverging trades involving wildlife and drugs.
Orders of automorphisms of smooth plane curves for the automorphism groups to be cyclic
Authors: Hayashi Taro
Published: May 2021

For a fixed integer $$d\ge 4$$

d
≥
4

, the list of groups that appear as automorphism groups of smooth plane curves whose degree is d is unknown, except for $$d=4$$

d
=
4

or 5. Harui showed a certain characteristic about structures of automorphism groups of smooth plane curves. Badr and Bars began to study for certain orders of automorphisms and try to obtain exact structures of automorphism groups of smooth plane curves. In this paper, based on the result of T. Harui, we extend Badr–Bars study for different and new cases, mainly for the cases of cyclic groups that appear as automorphism groups.
Transfer of resistance against soil-borne wheat mosaic virus from Triticum monococcum to hexaploid wheat (T. aestivum)
Authors: Schlegel R. , Pankovic D. , Koch F. , Ordon F. , Kastirr U. , Perovic D.
Published: May 2021

Resistance to soil-borne viruses as Soil-borne Wheat Mosaic Virus (SBWMV) has gained evident importance in wheat research and breeding. Very few varieties of bread and durum wheat are resistant to these viruses. Search for new sources of SBWMV is conducted worldwide and loci causing resistance have been described on the B and D genomes of tetraploid and hexaploid wheat. In the present study, a gene locus was identified on the A genome of Triticum monococcum and was successfully transferred to hexaploid wheat. In hexaploid wheat, it is expressed in a stable dominant manner. As this is the first SBWMV resistance gene located on the A genome, this locus is proposed as Sbm3.
Multi-strategy engineering greatly enhances provitamin A carotenoid accumulation and stability in Arabidopsis seeds
Authors: Sun Tianhu , Zhu Qinlong , Wei Ziqing , Owens Lauren A. , Fish Tara , Kim Hyojin , Thannhauser Theodore W. , Cahoon Edgar B. , Li Li
Published: May 2021

Staple grains with low levels of provitamin A carotenoids contribute to the global prevalence of vitamin A deficiency and therefore are the main targets for provitamin A biofortification. However, carotenoid stability during both seed maturation and postharvest storage is a serious concern for the full benefits of carotenoid biofortified grains. In this study, we utilized Arabidopsis as a model to establish carotenoid biofortification strategies in seeds. We discovered that manipulation of carotenoid biosynthetic activity by seed-specific expression of Phytoene synthase (PSY) increases both provitamin A and total carotenoid levels but the increased carotenoids are prone to degradation during seed maturation and storage, consistent with previous studies of provitamin A biofortified grains. In contrast, stacking with Orange (ORHis), a gene that initiates chromoplast biogenesis, dramatically enhances provitamin A and total carotenoid content and stability. Up to 65- and 10-fold increases of β-carotene and total carotenoids, respectively, with provitamin A carotenoids composing over 63% were observed in the seeds containing ORHis and PSY. Co-expression of Homogentisate geranylgeranyl transferase (HGGT) with ORHis and PSY further increases carotenoid accumulation and stability during seed maturation and storage. Moreover, knocking-out of β-carotene hydroxylase 2 (BCH2) by CRISPR/Cas9 not only potentially facilitates β-carotene accumulation but also minimizes the negative effect of carotenoid over production on seed germination. Our findings provide new insights into various processes on carotenoid accumulation and stability in seeds and establish a multiplexed strategy to simultaneously target carotenoid biosynthesis, turnover, and stable storage for carotenoid biofortification in crop seeds.