bluuebunny/crossref_metadata_2025 huggingface dataset:
Acute Liver Failure in a Pediatrician with COVID-19: a Case Report
Authors: Farhangnia Pooya , Safdarian Amir Reza , Delbandi Ali-Akbar
Published: March 2022

Here, we report a case of acute liver failure and a drastic increase of
liver enzyme in a pediatrician with COVID-19 infection without a history
of preexisting liver disease. Unfortunately, the patient passed away
several days after intensive care unit (ICU) admission.
Significant bronchodilator response in FEF25-75 for the diagnosis of asthma in children
Authors: Linares Marcela , Rodriguez Angelica , Icarte Danae , Martinez Bitter , Milla Valentina , Zygier Noelia , Olmos Claudio
Published: March 2022

Introduction: A spirometry with a significant bronchodilator response
(SBDR) in FEV1, a methacholine concentration that produces a 20% drop
in FEV1(PC20) ≤ 2 mg/ml and a positive exercise test (ET), have high
specificity for the diagnosis of asthma in children. The value of
FEF25-75 in spirometry has been questioned. The objective of this study
was to relate SBDR in FEF25-75 of spirometry with normal FEV1 and
FEV1/FVC, with bronchial hyperresponsiveness (BHR) to methacholine or
exercise in children aged 5 to 15 years with clinical suspicion of
asthma. Material and method: Cross-sectional study of spirometries
performed between January 2017 and December 2019 in children aged 5-15
years with suspected asthma, who had a methacholine and/or exercise test
within a period not exceeding 60 days. It was analyzed using STATA 14-0
and Microsoft Excel 2016 applying Chi-square tests. Results: The average
age was 9.04 years (range: 5 – 14 years), 56.17% male. Of 324
spirometries with normal FEV1 and FEV1/FVC, 66 (20.4%) presented SBDR
at FEF25-75. 47% and 33.3% of the children with and without RSB in
FEF25-75, respectively, had PC20 ≤ 2 mg/ml and/or positive TE (p =
0.0396). Conclusions: children with suspected asthma and normal
spirometry, with SBR in FEF25-75, had greater BHR than those without
SBDR in FEF25-75. The SBDR in FEF25-75 was not always accompanied by an
BHR that can confirm the diagnosis of asthma with high probability.
Invariant measure of a degenerately damped stochastic Lorenz-Stenflo system
Authors: Zhou Liangke , Zeng Caibin
Published: March 2022

Little seems to be known about the sensitivity of steady states for
stochastic systems. This paper discusses the problem of whether there is
an invariant measure in a degenerately damped stochastic Lorenz-Stenflo
model. Precisely, the solution is proved to be a nice diffusion via the
Lie bracket technique and non-trivial Lyapunov functions. The finiteness
of the expected positive recurrence time entails the existence problem.
On the other hand, a cut-off function is constructed to show the
non-existence result via proof by contradiction. For other interesting
cases, the expected recurrence time is shown to be infinite.
Refining the video head-impulse test diagnostic accuracy - a retrospective case-control study.
Authors: Faranesh Nabil , Abo-Saleh KHALDOON , Kaminer Margalith , Shupak Avi
Published: March 2022

Abstract Objective: To appraise the added benefit of refixation saccades
(RS) towards the improvement of the video head-impulse test (vHIT)
diagnostic accuracy in cases of suspected left horizontal semicircular
canal dysfunction. Study Design: Case-control. Setting: Tertiary
referral center. Participants: Twenty patients with a final diagnosis of
left horizontal semicircular canal dysfunction and 20 patients for whom
vestibular dysfunction was ruled out. Intervention: vHIT recordings of
40 patients with left horizontal semicircular canal (LHSCC)
vestibulo-ocular reflex (VOR) gain <0.8. Main outcome
measures: LHSCC VOR gain; Presence of RS and their frequency, latency,
and velocity characteristics. Results: Gain values > 0.72
were found in all patients with no vestibular disease and in 4 (20%)
patients having vestibulopathy. Significantly higher average left-sided
RS velocity and frequency were found among the vestibular patients. VOR
gain < 0.72 was found to be highly specific for the diagnosis
of vestibular dysfunction. However, for gain values in the range of
0.72-0.79 the presence of RS with frequency > 80% largely
improved vHIT diagnostic accuracy. CONCLUSIONS: Although VOR
gain<0.8 is considered to reflect dysfunction a significant
false positive rate for left-sided horizontal vHIT was found for gains
in the range of 0.72-0.79. The presence of RS with frequency
>80% could improve vHIT diagnostic ability in these
patients. Key words: video head impulse test, re-fixation saccades,
peripheral vestibular pathology, gain asymmetry in vHIT, lateral
semicircular canal hypofunction, saccadic frequency, corrective saccade
velocity
The Development of Locoregional Therapies as a Strategy for Reducing Cervical Cancer Mortality in Low to Middle Income Countries.
Authors: Chituku Tsitsi , Jones Susan , Phillips Roger
Published: March 2022

Early detection concomitant with appropriate treatment intervention for
pre-invasive cervical cancer has proved effective in the ‘war on
cervical cancer’ in the developed world. Unfortunately, these advances
have not been mirrored in the developing world, where incidence and
mortality rates are currently approximately 90% of the world’s burden.
Due to economic, infrastructure and skilled personnel constraints, the
impact of cytology screening as a method for early detection and
reducing mortality rates from cervical cancer is lower. Typically, women
present with advanced disease that is difficult to treat because of de
novo and pharmacokinetic resistance. Whilst the HPV vaccine is a welcome
development in the fight against cervical cancer, for women who are
outside the target age of vaccination, or indeed do not have access to
vaccination, screening remains the only form of protection. Current
excisional treatments available for cervical dysplasia are effective but
have limitations, including increased incidence of obstetric
complications and risk of recurrence. This is a particular issue in
cases of HIV, which is endemic in the regions most affected by cervical
cancer. Therefore, early detection combined with early treatment is an
attractive strategy to reduce the number of women presenting with drug
resistant disease in developing countries where cytology screening and
vaccination services are poorly developed. This review makes the case
for developing a locoregional treatment therapy for cervical dysplasia
which could be incorporated into a cervical cancer screening strategy in
a rural setting within a developing country.
UNPREDICTABLE SOUND STRESS MODEL CAUSES MIGRAINE-LIKE BEHAVIORS IN MICE WITH SEXUAL DIMORPHISM
Authors: Viero Fernanda , Rodrigues Patrícia , Frare Julia , Silva Náthaly da , Ferreira Marcella , Silva Ana da , Pereira Gabriele Cheiran , Ferreira Juliano , Pillat Micheli , Bochi Guilherme , Nassini Romina , Geppetti Pierangelo , Trevisan Gabriela
Published: March 2022

Background and purpose Migraine represents one of the major causes of
disability worldwide and is more prevalent in women, it is also related
to anxiety symptoms. Stress is a frequently reported trigger in migraine
patients, such as sound stress, but the underlying mechanisms are not
fully understood. However, it is known that patients with migraine have
higher levels of plasma inflammatory cytokines and calcitonin
gene-related peptide (CGRP). Stress mediated by unpredictable sound is
already used as a model of painful sensitization, but migraine-like
behaviors and sexual dimorphism have not yet been evaluated. This study
characterized the nociception and anxiety-related symptoms after the
induction of unpredictable sound stress in mice. Experimental approach
C57BL/6 mice (20-30 g) were exposed to unpredictable sound stress for 3
days. Mainly, after 7 days of the last stress session mice developed
hind paw, periorbital mechanical allodynia, grimacing pain behavior,
anxiety-like, and reduced exploratory behavior. Key results These
nociceptive and behavioral alterations detected in this model were shown
mostly in female stressed mice. Besides, 7th-day post-stress
nociception, these behaviors were consistently abolished by CGRP
receptor antagonist olcegepant (BIBN4096BS, 100mg/kg by intraperitoneal
route) until 3 h after treatment in stressed mice. In addition, we
demonstrated an increase in levels of IL-6 and TNF-α and CGRP levels in
stressed mice plasma, with female with higher levels when compared to
male mice. Conclusions and implications This stress paradigm allows
further preclinical investigation of mechanisms contributing to migraine
pain, which appear to be distinct in male and female mice.
De novo biosynthesis of α-aminoadipate via multi-strategy metabolic engineering in Escherichia coli
Authors: Zhang Yang , Liu Meng , Cai Bingqi , He Keqin , Wang Meng , Chen Biqiang , Tan Tianwei
Published: March 2022

As a non-protein amino acid, α-aminoadipate is used in the fields of
medicine, chemical engineering, and others. In addition, α-aminoadipate
is an important precursor for the synthesis of β-lactam antibiotics. In
this study, we construct a biosynthesis pathway of α-aminoadipate in
Escherichia coli using lysine as the precursor and produce
α-aminoadipate using a microbial cell factory for the first time. In
addition, we regulate the cell metabolism to improve the titer of
α-aminoadipate via multi-strategy metabolic engineering. First, a novel
synthetic pathway was constructed to realize the de novo synthesis of
α-aminoadipate with the titers of 82 mg/L. Second, the key enzymes
involved in enhancing precursor synthesis were overexpressed and the CO2
fixation process was introduced, and these led to 80% and 34%
increases in the α-aminoadipate concentration, reaching 147 mg/L and 110
mg/L, respectively. Third, cofactor regulation was used to maintain the
coupling balance of material and energy, with the intracellular
α-aminoadipate concentration reaching 140 mg/L. Fourth, the weakening of
the synthesis of acetic acid was used to strengthen the synthesis of
α-aminoadipate, and this resulted in the enhancement of the
α-aminoadipate concentration by 2.2 times, reaching 263 mg/L. Finally,
combination optimization was used to promote the production of
α-aminoadipate. The titers of α-aminoadipate reached 415 mg/L, which was
4 times higher than that of the parent strain. This study is the first
to present the effective biosynthesis of α-aminoadipate in E. coli.
Case report of an asymptomatic Giant Left Atrial Appendage Aneurysm in an adult
Authors: Qian Yongjun , Chen Bo , Tan Songtao
Published: March 2022

Introduction: Left atrial appendage aneurysm (LAAA) is an
extremely rare cardiac abnormality with potentially life-threatening
risks. Most LAAA were detected because of the symptoms triggered by it,
while asymptomatic LAAA were detected incidentally. Once LAAA is
diagnosed, early surgical intervention is generally recommended.
Case presentation: We reported a case of an 18-year-old female
with giant congenital LAAA without any symptoms or surgical history. In
an incidental transthoracic echocardiography (TTE) examination, a
saccular structure adjacent to her left rear of the heart was
encountered. Further CT and MRI examination established the diagnosis of
LAAA. The LAAA was corrected via open heart surgery with cardiopulmonary
bypass, and this patient recovered well and discharged uneventfully.
Conclusion: TTE is the primary tool to diagnose LAAA.
Transesophageal echocardiography (TEE), CT and MRI can be used for more
accurate diagnosis. Early operation is a generally recommended and
widely used intervention to prevent adverse events.
Diagnostic challenges of pericardial mesothelioma: A case report and review of literature
Authors: Thanalingam Yattheesh , Sinha Sanjay , J David McCormack , Kejriwal Nand K.
Published: March 2022

Primary pericardial malignant mesothelioma (PPMM) is a rare malignancy
arising from the serous mesothelial lining of the pericardium. These
neoplasms are aggressive, pose diagnostic difficulties, and have a poor
prognosis. The median survival is less than six months. Presenting
symptoms are non-specific and include fatigue, dyspnea, and low-grade
fever. Given the nature of presenting symptoms, it is imperative that
appropriate imaging, tissue sampling, and histological analysis are
undertaken to establish a clinical diagnosis. In cases of localised
disease, surgical resection remains the primary treatment. In advanced
disease, chemotherapy or palliative procedures may be beneficial. We
describe two cases of PPMM and provide an update and guidance on the
contemporaneous management of this challenging condition.
Impact of the posterior mitral leaflet anatomical variation on the efficacy of ValveClamp using three-dimensional transesophageal echocardiography
Authors: Chunqiang Hu , Ge Zhenyi , Li Wei , Xie Yashu , Kong Dehong , Chen Haiyan , Shu Xianghong , Pan Cuizhen
Published: March 2022

Background Multiple studies illustrated that mitral valve (MV)
leaflet presented variations, and there is little known about the
posterior mitral leaflet (PML) anatomical variation affecting residual
MR in interventional mitral valve edge-to-edge repair (TEER) with the
ValveClamp system in patients with degenerative mitral regurgitation
(DMR) using three-dimensional transesophageal echocardiography (3D TEE).
Method Fifty-five DMR patients treated with TEER were included
and performed 3D TEE pre- and post-procedure immediately. 3D TEE images
were proceeded to characterize the posterior mitral leaflet anatomy and
investigate the relationship between variations and residual mitral
regurgitation (MR). Results Variations in PML were found in 16
patients (32%) of this series, including 3 cases (6%) of one scallop,
8 cases (16%) of two scallops, and 5 cases (10%) of four scallops.
Residual MR ≥ 2+ were found in 3 patients with variant PML and 8
patients with classical PML post procedures, while other patients were
all < 2+. The Chi-square test results showed no correlation
between residual MR and PML variants (18.8% vs. 23.5, ᵪ
= 0, p = 0.988). Of the 5 patients with 4 scallops,
3 had poor clinical outcomes. Two patients were converted to surgical
mitral valve repair and one died 1 month after implantation.
Conclusions 3D TEE provides a novel and non-invasive method to
characterize and classify PML variations. Variations in PML are
relatively common and not associated with residual MR 2+.
Extract Propane and Ethane from Methane on Ultramicroporous Carbon Adsorbent with Record Selectivity
Authors: Chen Fuqiang , Guo Kaiqing , Huang Xinlei , Zhang Zhiguo , Yang Qiwei , Yang Yiwen , Ren Qilong , Bao Zongbi
Published: March 2022

Separation of light hydrocarbon mixtures and extraction of C3H8 and C2H6
from CH4 are of significant importance in natural gas purification and
upgrade. Microporous carbon adsorbents are promising in light
hydrocarbons separation, but to fabricate uniform ultramicropores to
boost separation selectivity remains challenging. Herein, we fabricated
a series of poly(vinylidene chloride) resins-derived ultramicroporous
carbon adsorbents with relatively uniform pore size (5.2-5.3 Å) by
activator-free pyrolysis. The optimal C-PVDC-800 exhibited record-high
IAST selectivity of C3H8/CH4 (3387) and C2H6/CH4 (75) as well as Henry’s
selectivity of C3H8/CH4 (369) among all reported adsorbents under
ambient conditions, combined with ultrahigh uptake of C3H8 (3.9 mmol
g-1, 0.05 bar) and C2H6 (2.67 mmol g-1, 0.10 bar) at low partial
pressures and 298 K. More importantly, fast gas adsorption kinetics were
realized, favorable in fixed-bed adsorption applications. Breakthrough
experiments and cycling tests further confirm the superb separation
performance of extraction of C3H8 and C2H6 from CH4.
Vaccine-Associated Atrial Fibrillation
Authors: Al-yafeai Zaki , Ghoweba Mohamed , Aziz David , Ananthaneni Anil , Hanna-Moussa Shafik , Sabayon Muhie
Published: March 2022

Aim: Vaccines have been mainly described to provide cardioprotective
effects with rare reports showing rare association with myopericarditis.
However, vaccines have not been well studied regarding its effects on
heart rhythm disorders. Methods: we used vaccine adverse event reporting
system (VAERS) between 1990-2021 to search for atrial fibrillation and
other less prevalent arrhythmia. Disproportionality signal analysis was
conducted by measuring reporting odds ratio (ROR) with 95% confidence
interval (CI). Results: Over 1,300,000 adverse events were reported
between 1990-2021. Among these events, atrial fibrillation was reported
2149 times in association with various vaccines. 90% of atrial
fibrillation was associated with COVID-19 vaccines with ROR of 13.18 (CI
95%: 11.3 to 15.4) (P<0.0001). Interestingly, influenza
vaccines, polyvalent polysaccharide pneumococcal (PPSV23) vaccine,
pneumococcal 13-valent (PCV13) vaccine, zoster vaccine, and
tetanus-containing vaccines were significantly associated with reduced
atrial fibrillation. Finally, our analysis showed that COVID-19 vaccines
were associated with much higher incidence of other cardiac arrhythmias
compared with other vaccines. Conclusions: While vaccines have not been
linked to heart rhythm disorders, the introduction of COVID-19 vaccines
in 2020 showed significant association with atrial fibrillation. This
study showed unprecedent detrimental effect of COVID-19 vaccines on
atrial fibrillation and warrants the need to take that into
consideration when prescribing COVID-19 vaccines.
Clinical Analysis of Struma Ovary
Authors: Yang Shizhang , Mao yu rong
Published: March 2022

Abstract: Objective: To investigate the histopathologically, diagnostic
measure and prognosis of Struma Ovarii (SO). Design and Setting:From
Jan.2009 to Jan.2022, the general clinical data, results of laboratory
examinations, surgical and histopathological test results of 11
patients, age 25-66 years, mean45.5 years old, with struma ovary in the
department of Gynecoloy in The Affiliated Hospital of Jiangnan
University, were analyzed retrospectively. Population or Sample：1
Struma Ovarii (SO) cases. Methods: Methods Clinical data of 11 Struma
Ovarii (SO) cases were retrospectively studied, analyzed the
histopathologically, diagnostic measure and prognosis of (SO). In this
study, the procedure followed in line with our hospital customized
ethical standards, and with the signing of informed consent in clinical
research which obtained a informed consent from the patients. Results:
The clinical manifestations of these patients were pelvic mass,
bloating, breathing difficulty, peritoneal dropsy, pelvic mass and the
CA125 levels may be elevated. Conclusions: Struma Ovarii is a highly
specific ovarian teratoma, mostly benign. Struma Ovarii is rare in
clinical because its no obvious clinical feature and characteristics
preoperative and intraoperative diagnosis was difficult. Its
preoperative misdiagnosis rate is high but the malignant transformation
rate is very low, prognosis good for most of patients. Intraoperative
frozen histopathological examination for early diagnosis can avoid
unnecessary surgery to expand. Serial measurement of serum thyroglobulin
is a sensitive and cost-effective follow-up tool. A period of at least
10 years is recommended.
The Importance of Aeroallergen Sensitivity in Children with Cystic Fibrosis
Authors: ATAY ÖZGE , ASİLSOY SUNA , KÖSE SEDA ŞİRİN , ATAKUL GİZEM , al serdar , BOYACIOĞLU ÖZGE KANGALLI , Uzuner Nevin , Karaman Ozkan
Published: March 2022

Background: Cystic fibrosis (CF) is an inherited autosomal recessive
disorder that causes chronic airway disease. In addition to genetic
factors, environmental factors may affects the clinical phenotype of CF.
In our study, the presence of aeroallergen sensitivity in our patients
with CF and its effects on clinical findings were evaluated. Materials
and Methods: Demographic characteristics, clinical and laboratory
findings, skin prick test (SPT) results, and Modified
Shwachman-Kulczycki (MSK) scores of patients diagnosed with CF followed
in the Pediatric Respiratory and Allergy Clinic of Dokuz Eylul
University Faculty of Medicine were evaluated. Results: We evaluated 51
patients with CF with a median age of 10 (6-18) years. The mean MSK
score of the patients was 72.54±11.50, and the mean predictive value of
forced expiratory volume (FEV1) in the first second of 41 patients was
80.43±19.50. According to SPT, aeroallergen sensitivity was detected in
17 (33.3%). The frequency of bacterial colonization and bronchiectasis
was higher, MSK scores were lower in AF-sensitive patients (p≤0.01).
However, there was no similar difference in other allergen
sensitivities. MSK scores and predictive FEV1 values of 25 (49%)
patients with bacterial colonization were significantly lower than those
without colonization (p=0.001, p=0.005, respectively). Conclusion:
Aeroallergen sensitivity was detected in approximately 1/3 of CF
patients. Although it has been emphasized in studies that environmental
factors may have an impact on lung functions and clinical conditions in
CF, the effect of allergens other than AF sensitivity may be less
important compared to other environmental factors such as the presence
of bacterial colonization. Keywords: Cystic fibrosis, atopy, children,
asthma, Aspergillus fumigatus, Pseudomonas aeruginosa
CONTRAST INDUCED ACUTE HYPERSENSITIVITY REACTION IN A 10-YEAR-OLD PATIENT
Authors: Fatima Nabeela , Badar Juveria , Khatoon Fatima
Published: March 2022

Immediate skin rashes,flushing,urticaria
pruritus,rhinorrhea,nausea,short retching,and/or vomiting,coughing, and
vertigo are symptoms of mild hypersensitivity reactions.Recognizing the
type of contrast reaction is crucial to treating it.Rapid recognition of
the signs and symptoms of a contrast response allows radiology personnel
to quickly determine the type of reaction, allowing for faster treatment
and reversal.
Gβγ-GRK2 inhibition ameliorates synovitis and pathological macrophage activation in murine post-traumatic osteoarthritis
Authors: gounder Vengadeshprabhu Karuppa , Pinamont William , Yoshioka Natalie , Elbarbary Reyad , Kamal Fadia
Published: March 2022

Background and Purpose: The G protein-coupled receptor kinase 2 (GRK2)
is an important regulator of inflammation and pathological macrophage
phenotype in a variety of diseases. We hypothesize that Gβγ-GRK2
signaling promotes early inflammatory response and chondrocyte loss in
osteoarthritis (OA). Experimental Approach: Using the destabilization of
the medial meniscus (DMM) model in 12-week-old male C57BL/6 mice, we
determined the role of Gβγ-GRK2 signaling in synovitis, macrophage
activation, and OA development. We achieved Gβγ-GRK2 inhibition at the
time of DMM by administering the Gβγ inhibitor “gallein” and the GRK2
inhibitor “paroxetine” daily, starting from 2 days before DMM surgery,
for a duration of 1 or 12 weeks. Synovial and cartilage structural
changes were evaluated by histomorphometry. Molecular events and
macrophage activation were examined using immunofluorescence staining,
and chondrocyte apoptosis by TUNEL staining. We studied the direct role
of Gβγ-GRK2 in synovitis and macrophage activation in vitro using SW982
and THP1 cells. Key Results: Continuous Gβγ-GRK2 inhibition initiated at
the time of DMM attenuated OA development and decreased chondrocyte loss
more effectively than delayed treatment. GRK2 expression and M1
macrophage phenotype were elevated in the inflamed synovium, while early
gallein and paroxetine treatment for 1 and 12 weeks following DMM
resulted in their reduction and upregulated M2 macrophage phenotype. In
vitro experiments showed that Gβγ-GRK2 inhibition attenuated synoviocyte
inflammation and M1 phenotype. Conclusion and Implications: We show that
early Gβγ-GRK2 inhibition is of higher therapeutic efficacy in OA than
delayed inhibition, as it prevents OA development by inhibiting the
early inflammatory response.
Food quantity and quality shapes reproductive strategies of Daphnia
Authors: Bednarska Anna
Published: March 2022

In freshwater environments, one of the challenges aquatic grazers face
are periods of suboptimal food quantity and quality. In a life table
experiment, the effect of food quantity (a gradient of algae
concentration) and quality (a diet of cyanobacteria) on the life history
and resource allocation strategy in Daphnia magna was tested.
Growth-related traits were similarly affected by both low food quantity
and quality, and the reproductive strategies differed. The per-clutch
investment (clutch volume) did not differ between Daphnia fed with
cyanobacteria and underfed mothers, but resources were differently
allocated; underfed mothers increased their per-offspring investment by
producing fewer, but larger eggs, whereas cyanobacteria-fed mothers
invested in a greater number of eggs of smaller size. I argue that both
strategies of resource allocation (number vs. size of eggs) may be
adaptive under the given food regime. The cyanobacteria diet-driven
fitness losses are comparable to losses caused by low food quantity.
An Initial Boundary Value Problem for a Pseudoparabolic Equation with a Nonlinear Boundary Condition
Authors: Aitzhanov Serik , Antontsev Stanilslav , Zhanuzakova Dinara
Published: March 2022

An initial-boundary value problem for a quasilinear equation of
pseudoparabolic type with a nonlinear boundary condition of the
Neumann-Dirichlet type is investigated in this work. From a physical
point of view, the initial-boundary value problem considered here is a
mathematical model of quasi-stationary processes in semiconductors and
magnets, which takes into account a wide variety of physical factors.
Many approximate methods are suitable for finding eigenvalues and
eigenfunctions in problems where the boundary conditions are linear with
respect to the desired function and its derivatives. Among these
methods, the Galerkin method leads to the simplest calculations. In this
article, by the Galerkin method to prove the existence of a weak
solution to the initial-boundary value problem for a pseudoparabolic
equation in a bounded domain. On the basis of a priori estimates, we
prove a local existence theoremand uniqueness for a weak generalized
solution of the initial-boundary value problem for the quasilinear
pseudoparabolic equation. A special place in the theory of nonlinear
equations is occupied by the study of unbounded solutions, or, as they
are called in another way, blow-up regimes. Nonlinear evolutionary
problems admitting unbounded solutions are globally unsolvable. In the
article, sufficient conditions for the blow-up of a solution in a finite
time in a limited area with a nonlinear Neumann-Dirichlet boundary
condition are obtained.
Life history implications of kinship structure in an Atlantic herring schooling aggregation
Authors: Kho James , McCracken Gregory , McDermid Jenni , Ruzzante Daniel
Published: March 2022

Kinship in natural marine fish systems has been little explored in part
due to limitations of available genomic approaches. This is especially
true for very abundant and commercially exploited marine pelagic fish
with broadcast spawning. Recent advances in genomics have however,
facilitated an improved understanding of population structure in marine
systems at fine geographic scales. Here, we identify kinship structure
in an aggregation of Atlantic herring (Clupea harengus) juveniles. We
identified 11 half-sib pairs using a suite of 92 sequenced
microsatellite DNA markers in a sample of N=1391 herring individuals
comprising two cohorts (ages 0+ and 1+) collected from the 2018 Fall
research survey of the Southern Gulf of St. Lawrence. In addition, we
were also able to detect a full-sib pair using the combination of
half-sib pairs and whole mitochondrial DNA (mtDNA) analysis. This study
suggests the presence of kinship structure in a juvenile herring
aggregation three months or more post hatching with implication for our
understanding of herring early life history.
New episiotomy: A prospective case series study
Authors: Ostrzenski Adam
Published: March 2022

Objectives To establish anatomical structures responsible for a
resistance force on a fetal head during vaginal delivery; assess the
postpartum perception of perineal pain and superficial dyspareunia;
develop a new episiotomy. Design A prospective observational case series
study. Setting International sites. Population Eighteen pregnant women
in labor Methods Small V-shape excision was made on the
posterior-lateral vaginal outlet without incising the posterior perineum
or vaginal wall. Simple interrupted sutures were used to repair the
surgical defect (outlectorrhaphy). Histological examinations were
performed on excised specimens. Main Outcome Measures The primary
maternal outcome measured postpartum perineal pain; the secondary
outcome measured occurrences of superficial dyspareunia, results of
Ostrzenski’s vaginal outlectomy, and APGAR scores measured the neonatal
outcome. Results The small V-shape excision widened the vaginal outlet
sufficiently for a vaginal delivery. Outlectorrhaphy required two-three
simple interrupted sutures. All subjects were delivered vaginally with
median newborns’ weight of 3,550 gm ±250gm and median APGAR scores of 9
±1 at 5 minutes. One patient experienced a grate II extension tear with
bleeding heavier than an uncomplicated vaginal outlectomy. Postpartum
patients reported no moderate or severe perineal pain and no superficial
dyspareunia. Histology showed that the vaginal outlet was deferred from
the vaginal walls. Conclusions The vaginal outlet is responsible for
resistance force on a fetal head. No moderate or severe perineal pain or
dyspareunia occurred in this study group. Ostrzenski’s vaginal
outlectomy widens the vaginal outlet sufficiently for a fetal vaginal
birth, and it is easy to repair.
Implementation of a piritramide based patient-controlled analgesia (PCA) as a standard of care is not effective for pain control in late abortion induction: a prospective cohort study from a patient perspective
Authors: Padrón Laura Tascón , Emrich Norah Lynn-Anne , Strizek Brigitte , Link Carolina , Hilbert Tobias , Klaschik Sven , Meissner Winfried , Gembruch Ulrich , Jimenez-Cruz Jorge
Published: March 2022

Objective To assess whether the implementation of patient-controlled
analgesia (PCA) with piritramide using an automatic pump system under
routine conditions is effective to reduce pain in late abortion
inductions Design Prospective observational cohort study Setting
Patients requiring medically indicated abortion induction from 14 weeks
of pregnancy onwards between July 2019 and July 2020 at the department
of Obstetrics and Prenatal Medicine of the Bonn University Hospital in
Germany. Methods Evaluation of pain management after implementation of a
PCA system compared with previous nurse-controlled tramadol-based
standard under routine conditions. Patients answered a validated pain
questionnaire and requirement of rescue analgesics was assessed. Pain
intensity and satisfaction were measured on a ten-point numeric rating
scale. Main Outcome Measure Maximal pain intensity Results Forty
patients were included. Patients using Piritramide-PCA complained of
higher pain sores than those in the standard group (6.90 (± 2.34) vs.
4.83 (± 2.87), (p < 0.05)). In both groups the level of
satisfaction with the analgesia received was comparable (8.00 (± 2.45)
vs 7.67 (± 2.62), (p = 0.7)). Patients in the PCA group suffered more
nausea (63.2% vs 30% respectively, OR 4.0, 95% CI 1.05-15.20,
p<0.05) and expressed more the desire for more analgesic
support compared to the control group (OR 5.7 (1-33.25), p = 0.05).
Conclusion Women with abortion induction after 14 weeks of gestation
suffer from relevant severe pain, which requires adequate therapy.
However, addition of PCA does not seem to bring any advantage in
patients undergoing this procedure.
A network-based dynamic criterion for early warning signal discovery: Prediction and early diagnosis for lung adenocarcinoma
Authors: Huang Xin , Su Benzhe , Wang Xingyu , Zhou Yang , He Xinyu , Liu Bing
Published: March 2022

Complex diseases generally result from dysfunction of relevant module
molecules, which dynamically change with time and conditions, rather
than that of an individual molecule. In this study, a novel network
construction algorithm for identifying early warning network signals
(namely, IEWNS) is proposed for improving the performance of early
diagnosis. To this end, we theoretically derived a network-based dynamic
criterion, namely, the relationship of variation (RV), to construct
dynamic networks. RV infers correlation t statistics to measure dynamic
changes in molecular relationships during the process of disease
development. Based on the dynamic networks constructed by IEWNS, early
warning network signals used to represent the occurrence of complex
disease deterioration can be defined without human intervention. IEWNS
was employed to perform a comprehensive analysis of gene expression
profiles of lung adenocarcinoma (LUAD) from The Cancer Genome Atlas
database and the Gene Expression Omnibus database. The experimental
results suggest that the network biomarker selected by IEWNS can
facilitate a better understanding of pathogenetic mechanisms and help to
achieve effective early diagnosis of LUAD. In conclusion, IEWNS provides
novel insight into the pathogenic mechanisms of complex diseases and
helps to define prospective biomarkers for assessing disease
deterioration.
New model of pressure drop for the foam trays with dynamic bubbling process analysis
Authors: Yan Peng , Li Hong , Li Xingang , Gao Xin
Published: March 2022

Open-cell foams as the column tray are promising candidates for the
purpose of process intensification in the distillation process. In this
paper, the real foam porous structure is obtained based on Micro
Computed Tomography (µ-CT), and the bubble formation process on
pore-scale foam tray is discussed based on the VOF-CSF model (volume of
fluid method-continuous surface force). The results show that the
wettability (CA), superficial gas velocity (Ug), porous structure, and
clear liquid layer height (HCL) all affect a crucial factor of the foam
tray - the liquid holdup in the porous channels (LHPC). It determines
the effective porosity, which in turn affects the bubbling frequency and
pressure drop. Meanwhile, the evolutionary mechanism of instantaneous
pressure drop is analyzed based on the flow patterns, force analysis and
interfacial phenomena. Moreover, the new model to predict pressure drop
is proposed based on LHPC, which shows good consistency with
experiments.
Pulmonary vein isolation after partial pulmonary vein repair in patient with heterotaxy, anomalous right pulmonary veins and atrial fibrillation with associated cardiomyopathy
Authors: Gupta Tripti , Yousuf Adil , Benn Francis , Hiltbold A. E. , Morin Daniel , Rogers Paul , Polin Glenn , Khatib Sammy , Hoyt Walter , Thomas Patricia , Young Thomas , Bernard Michael
Published: March 2022

Partial anomalous pulmonary venous connection (PAPVC) is an unusual
congenital anomaly with variable sites of attachment of the atypical
pulmonary veins. Anomalous right pulmonary vein return can be surgically
corrected if left to right shunt physiology becomes hemodynamically
significant. In such patients, as in the general population, the
development of arrhythmia-associated heart failure due to atrial
fibrillation prompts consideration of pulmonary vein isolation. There
are limited reports of pulmonary vein isolation on surgically repaired
PAPVC. This case highlights successful isolation of surgically corrected
right pulmonary veins in a patient with PAPVC and atrial fibrillation
associated heart failure.
A Recursive Formulation of One-Electron Coupling Coefficients for Spin-Adapted Configuration Interaction Calculations Featuring Many Unpaired Electrons
Authors: Ugandi Mihkel , Römelt Michael
Published: March 2022

This work reports on a novel computational approach to the efficient
evaluation of one-electron coupling coefficients as they are required
during spin-adapted electronic structure calculations of the
configuration interaction type. The presented approach relies on the
equivalence of the representation matrix of excitation operators in the
basis of configuration state functions and the representation matrix of
permutation operators in the basis of genealogical spin eigenfunctions.
After the details of this connection are established for every class of
one-electron excitation operator, a recursive scheme to evaluate
permutation operator representations originally introduced by Yamanouchi
and Kotani is recapitulated. On the basis of this scheme we have
developed an efficient algorithm that allows the evaluation of all
nonredundant coupling coefficients for systems with 20 unpaired
electrons and a total spin of S = 0 within only a few hours on a simple
Desktop-PC. Furthermore, a full-CI implementation that utilizes the
presented approach to one-electron coupling coefficients is shown to
perform well in terms of computational timings for CASCI calculations
with comparably large active spaces. More importantly, however, this
work paves the way to spin-adapted and configuration driven selected
configuration interaction calculations with many unpaired electrons.
An unusual cause for inappropriate defibrillator shock.
Authors: Bera Debabrata , Kar Ayan , Majumder Biswajit , Ghosh Arup Kumar , Bhattacharyya Debdutta
Published: March 2022

A 50-year-old lady with dilated cardiomyopathy and scar VT underwent
single chamber implantable cardioverter-defibrillator (ICD, Medtronic
Ltd, ﻿Evera XT VR, DVBB2D1) implantation 2 months back. A Sprint Quattro
secure 6947 DF1 dual coil lead was placed at RV apex. Now, she presents
with an episode of ICD shock while having breakfast. The device
interrogation shows a 36 J shock in VF zone (Fig 1A). However, the
stored electrograms (EGM) reveal distinct QRS complexes in the far-field
EGM; hence, suggesting the shock is related to oversensing. Fig 1B shows
2 panels of another recent episode. Fortunately, there was aborted
therapy as there was intermittent resolution of the oversensing. The
lead impedance was normal but threshold was high. Is it possible to
predict the reason for the oversensing from the EGM and how to
troubleshoot?
Peutz–Jeghers syndrome revealed by recurrent small bowel intussusceptions in children: A case report
Authors: rahma chtourou , Najoua Ben Kraiem , Mohamed zouari , Manel Mellouli , Rim Dghaies , Mahdi Ben Dhaou , Sellami Tahya , Riadh Mhiri
Published: March 2022

Peutz-Jeghers syndrome is a rare but potentially life threating
syndrome. We report here the case of a young girl who presented
recurrent small bowel intussusceptions. Laparotomy exploration showed
many jejunal polyps leading to jejunojejunal intussusceptions. These
were removed via mini enterotomies and pathological examination
concluded to Peutz-Jeghers polyps.
ORIGINAL ARTICLE Differentiating Typical Tako-Tsubo Syndrome from extensive anterior STEMI: look behind the anterior wall
Authors: Pernigo Matteo , Berti Marco , Dinatolo Elisabetta , Cozza Fabiana , cuccia claudio
Published: March 2022

Background: Tako-tsubo syndrome (TTS) in its most typical form
shares common features with anterior ST segment elevation myocardial
infarction (AMI) during acute presentation. Differential diagnosis
between the two conditions is often challenging especially if ST segment
elevation is associated with extensive apical akinesis. Methods:
we sought to systematically analyze ECG and echocardiographic parameters
including LV longitudinal strain and two new indexes: the inferior-apex
ratio (IAR) and the inferior-lateral-apex ratio (ILAR), to assess if
ventricular involvement may be different in TTS and AMI. Results:
A retrospective cohort study was conducted with 2 groups: patients with
TTS (n=22) and patients with extensive anterior STEMI (n=22). Lack of ST
elevation in V1 was associated with TTS with sensitivity and specificity
of 86%, positive and negative predictive value of 86%. Longitudinal
strain in mid inferior and mid inferior-lateral segments were more
compromised in TTS: - 4.3±6.4% and -5.4± 5.4% in TTS vs -10.2±5.5%
and -9.9 ±4.9% in AMI, respectively (P<0.01 for all). By
multivariate analysis, both longitudinal strain values, inferior-apical
ratio (IAR) <1 and inferior-lateral-apical ratio (ILAR)
<1 were independently associated with diagnosis of TTS during
acute phase. Conclusions: our results suggest that impaired
contractility extending beyond apex to mid inferior and inferior-lateral
walls can be easily assessed by IAR and ILAR, and these indexes
facilitate non-invasive differentiation of TTS from extensive anterior
STEMI.
Organocatalyzed Beckmann Rearrangement of Cyclohexanone Oxime by Trifluoroacetic Anhydride in Microreactors
Authors: Du Chencan , Wang Yubin , Deng Jian , Luo Guangsheng
Published: March 2022

The kinetics of the Beckmann rearrangement of cyclohexanone oxime (CHO)
catalyzed by trifluoroacetic anhydride (TFAA) and trifluoroacetic acid
(TFA) is proposed in this work. The effects of experimental parameters
on the reaction rate are studied in microreactors, including CHO
concentration, TFAA concentration, temperature, and caprolactam (CPL)
concentration. The reaction is verified as first-order and the reaction
rate shows a linear relationship with TFAA concentration and decreases
with the increasing of CPL concentration. The in-situ FTIR is adopted to
study the reaction mechanism and quantitative equilibrium relationship
of CPL with TFAA. Based on the experimental results, a reaction
mechanism is proposed and a kinetics model is established, which is in
good agreement with the experimental data. The TFAA/TFA catalytic system
allows high conversion and reaction rate compared with other organic
acids.
Brain abscess complicating hemophagocytic lymphohistiocytosis and Kawasaki disease in child: A case report
Authors: Zhu Yanjie , Li dengfeng , Wang jianjun , Luo rong , Cai qianyun
Published: March 2022

We present a case of immunocompetent boy with brain abscess (BA)
complicating hemophagocytic lymphohistiocytosis (HLH) and Kawasaki
disease (KD), which is rarely reported. During the recovery period of
BA, he had another fever accompanied by enlarged lymph nodes, eye
conjunctival congestion, strawberry tongue, swelling on hands and feet,
and exanthema. Simultaneously, further investigations revealed
bicytopenia, liver dysfunction, hyperferritinemia, coagulopathy and
hemophagocytosis. The patient was treated with antibiotics, intravenous
immunoglobulin (IVIG) and steroid that led to rapid resolution. Our
report highlights the importance of early detection and treatment of
HLH, and possible resolution without using immunosuppressive therapy in
infectious patients.
Design and optimization of a novel ellipsoidal baffle mixer with high mixing efficiency and low pressure drop
Authors: Zhao Shuangfei , Sheng Lianzhu , He Wei , Zhu Ning , Guo Kai
Published: March 2022

The fluid mixing plays a crucial role in continuous flow chemical
process. To enhance the mixing efficiency, a novel mixer was designed
and constructed by adding ellipsoidal baffle in large scale Y-shaped
mixer. The mixing performance in the mixers were studied by
computational fluid dynamics (CFD) simulations and experimentally
verified by the Villermaux/Dushman method. Furthermore, the mixer
structure was optimized, and the flow characteristics of the fluid in
the optimal mixer were investigated. The results indicated that the
mixer can improve the mixing performance and reduce the pressure drop on
the premise of ensuring high throughput by the secondary flow
disturbance of ellipsoidal baffle. All the findings reported provide
useful references for enhancement of mixing efficiency and reduction of
pressure drop in a large scale mixer.
Mitogenomic phylogeny of Typhlocybinae (Hemiptera: Cicadellidae) reveals homoplasy in tribal diagnostic morphological traits
Authors: Yan Bin , Dietrich Christopher , Yu Xiaofei , Jiao Meng , Dai Renhuai , Yang Maofa
Published: March 2022

The subfamily Typhlocybinae is a ubiquitous, highly diverse group of
mostly tiny, delicate leafhoppers. The tribal classification has long
been controversial and phylogenetic methods have only recently begun to
test the phylogenetic status and relationships of tribes. To shed light
on the evolution of Typhlocybinae, we performed phylogenetic analyses
based on 28 newly sequenced and 19 previously sequenced mitochondrial
genomes representing all currently recognized tribes. The results
support the monophyly of the subfamily and its sister group relationship
to Mileewinae. The tribe Zyginellini is polyphyletic with some included
genera derived independently within Typhlocybini. Ancestral character
state reconstruction suggests that some morphological characters
traditionally considered important for diagnosing tribes
(presence/absence of ocelli, development of hind wing submarginal vein)
are homoplastic. Divergence time estimates indicate that the subfamily
arose during the Middle Cretaceous and that the extant tribes arose
during the Late Cretaceous. Phylogenetic results support establishment
of a new genus, Subtilissimia Yan & Yang gen. nov.,
with two new species, Subtilissimia fulva Yan & Yang sp.
nov. and Subtilissimia pellicula Yan & Yang sp. nov.
(Typhlocybinae: Typhlocybini); but indicate that two previously
recognized species of Farynala distinguished only by the
direction of curvature of the processes of the aedeagus are synonyms,
i.e., Farynala dextra Yan & Yang, 2017 equals Farynala
sinistra Yan & Yang, 2017 syn. nov. A key to tribes of
Typhlocybinae is provided.
Novel Multiple Sclerosis Agents-Associated Cardiotoxicity: A Real-World Pharmacovigilance Study
Authors: Al-yafeai Zaki , Gonzalez Alexander Carvajal , Abduljabar Hamzah , Arvas Muhammed , Patel Shaan , Aziz David , Patel Neev
Published: March 2022

Background: Emerging novel therapeutics have been developed to hamper
the progression of multiple sclerosis. However, the adverse events
related to these new agents remain largely unknown. Therefore, we sought
to investigate the cardiovascular complications of these drugs. Methods:
Utilizing data from the U.S. Food and Drug Administration Adverse Events
Reporting System, we comprehensively evaluated the cardiovascular
complications of the newly FDA approved anti-multiple sclerosis agents.
Disproportionality signal analysis was conducted by measuring reporting
odds ratio (ROR) with 95% confidence interval of all the cardiovascular
adverse events adverse events since approval till 2021. Results: After
vetting the newly approved agents for multiple sclerosis, CD20 and CD25
inhibitors and sphingosine-1-phosphate receptors agonists were the
latest approved medications for multiple sclerosis since 2015. Two CD20
(ocrelizumab, ofatumumab) and one CD25 inhibitors (daclizumab) were
significantly associated with multiple cardiovascular adverse events.
Among all the cardiotoxic events; coronary artery disease, cardiac
failure and atrial fibrillation were the most predominant among CD20 or
CD25 blockers. Interestingly, Sphingosine-1-phosphate receptors agonists
showed much fewer reported cardiac adverse events. However, fingolimod
and siponimod were associated with significant bradycardia. Conclusions:
Our data revealed the new agents prescribed for multiple sclerosis have
cardiotoxic effects, including not only the known adverse effects
observed effects for S1P receptor modulators but also undefined
cardiovascular complications associated with CD20 and CD25 inhibitors.
These findings potentially instigate further studies to personalize
prescribing these agents for multiple sclerosis based on patient’s
cardiovascular profile.
Primary renal osteosarcoma; a case report and review of literature.
Authors: namdari farshad , pour mohammad javad nazar , Behzadi Arya , akbari mona , moradi hedieh , dialameh hossein
Published: March 2022

Primary renal osteosarcoma is exceedingly rare tumor with poor
prognosis. It has tendency to spread to distant sites . we report the
case of a 43-year-old female who presented with flank pain, gross
hematuria, weakness and weight loss and was treated with diagnosis of
primary renal osteogenic sarcoma