bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification Of PPIA As A Prognostic Biomarker Of Lung Adenocarcinoma From Bioinformatics Analysis
Authors: li lan , Yu Junlin , Chen Zhengting , Lu Fei , Cao Ke , Gao Jingyan , Chang Li , Li Wenhui
Published: February 2022

Background: We aim to investigate the expression of the peptidylprolyl isomerase A (PPIA) gene in lung adenocarcinoma(LUAD),and to investigate the diagnostic, prognostic value and correlation with immune infiltrates of PPIA in LUAD.Methods: Transcriptional expression profiles of PPIA between LUAD tissues and normal tissues were downloaded from the Cancer Genome Atlas (TCGA).The PPIA protein expression was assessed by the Clinical Proteomic Tumor Analysis Consortium (CPTAC) .Receiver operating characteristic(ROC) curve was used to differentiate LUAD from adjacent normal tissues.Kaplan-Meier method was conducted to assess the effect of PPIA on survival.Protein-protein interaction (PPI) networks were constructed by the STRING.Functional enrichment analyses were performed using the“ClusterProfiler”package.The relationship between PPIA mRNA expression and immune infiltrates was determined by tumor immune estimation resource (TIMER) and tumor-immune system interaction database (TISIDB).Results: The expression of PPIA in LUAD tissues was significantly upregulated than those in adjacent normal tissues. High PPIA mRNA expression was associated with lymph node metastases and high TNM stage. The ROC curve analysis showed that PPIA had an AUC value of 0.804(95% CI: 0.764-0.843).Kaplan-Meier survival analysis showed LUAD patients with high-PPIA had a worse prognosis than those with low-PPIA(mOS: 42.2months VS 87.2months,P＜0.001). Correlation analysis indicated PPIA mRNA expression was correlated with immune infiltrates.PPIA expression had correlations with CD4+ T cell (r = -0.29, P = 5.51e-11),macrophage M1 (r = 0.106, P = 1.84e-02), and B cell (r = -0.181, P =5.40e-5).Conclusion: Our research showed that PPIA could be used as a prognostic biomarker.Up-regulation of PPIA expression is significantly related to poor prognosis and immune infiltration of LUAD and may be a potential therapeutic molecular target for LUAD patients.
Identification of hub genes associated with HCV-related HCC progression based on risk score model
Authors: nie jiao , du chao , lin lu , gao xiaozhong
Published: February 2022

Background: Hepatitis C virus (HCV)-related cirrhosis is still one of the common etiologies of hepatocellular carcinoma (HCC). Most patients are already at advanced stage of due to the lack of reliable biomarkers. The aim of our study was to identify hub genes associated with early progression of HCV-related cirrhosis to HCV-related HCC by employing transcriptomic profiling datasets. Material and Methods: The datasets incorporating healthy controls and HCV-related HCC liver tissues from Gene Expression Omnibus database were analyzed to extract differentially expressed genes (DEGs). Enrichment analyses were performed to study biological function of common DEGs. The protein–protein interaction network from STRING was constructed in Cytoscape, and highly clustered hub genes were retrieved. Hub genes-related risk score prediction model was then established for further analysis.Results: We identified 188 common DEGs from GSE6764 and GSE62232, and highly clustered 28 hub genes were obtained. The expression of hub genes was associated with HCV-related HCC progressed from HCV-related cirrhosis. The risk score model performed well for distinguishing HCV-related HCC at very early stage, early stage, advanced stage, or very advanced stage from HCV-related cirrhosis (AUCs: 0.887~1). Among the hub genes, FAM83D expression was markedly reduced in HCV-related cirrhosis by comparison to controls and was progressively increased as HCC development. Risk score model based on FAM83D also revealed good performance in distinguishing between HCV-related HCC and cirrhosis (AUCs: 0.838~1).Conclusion: The 28 hub genes especially FAM83D might serve as potential biomarkers for identifying HCV-related HCC at earlier stage and as promising therapeutic targets.
Genomics Improves Risk Stratification of Adults with T-Cell Acute Lymphoblastic Leukemia Patients Enrolled in Measurable Residual Disease-Oriented Trials
Authors: González-Gil Celia , Morgades Mireia , Lopes Thaysa , Fuster-Tormo Francisco , García-Chica Jesús , Zhao Ran , Montesinos Pau , Torrent Anna , Diaz-Beya Marina , Coll Rosa , Hermosín Lourdes , Mercadal Santiago , González-Campos José , Zamora Lurdes , Artola Teresa , Vall-Llovera Ferran , Tormo Mar , Gil-Cortés Cristina , Barba Pere , Novo Andrés , Ribera Jordi , Bernal Teresa , Ugarriza Paula López , Queipo María-Paz , Martínez-Sánchez Pilar , Giménez Alicia , González-Martínez Teresa , Cladera Antonia , Cervera José , Fernández-Martín Rosa , Ardaiz María Ángeles , Vidal María Jesús , Baena Ángela , López-Bigas Nuria , Bigas Anna , Maciejewski Jaroslaw , Orfao Alberto , Ribera Josep Maria , Genescà Eulalia
Published: February 2022

Genetic information has been crucial to understand the pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL) at diagnosis and at relapse, but still now a days has a limited value in a clinical context. Few genetic markers are associated with the outcome of T-ALL patients, independently of measurable residual disease (MRD) status after therapy. In addition, the prognostic relevance of genetic features may be modulated by the specific treatment used. We analyzed the genetic profile of 145 T-ALL patients by targeted deep sequencing. Genomic information was integrated with the clinical-biological and survival data of a subset of 116 adult patients enrolled in two consecutive MRD-oriented trials of the Spanish PETHEMA (Programa Español de Tratamientos en Hematología) group. Genetic analysis revealed a mutational profile defined by DNMT3A/ N/KRAS/ MSH2/ U2AF1 gene mutations that identified refractory/resistant patients. Mutations in the DMNT3A gene were also found in the non-leukemic cell fraction of patients with T-ALL, revealing a possible mutational-driven clonal hematopoiesis event to prime T-ALL in elderly. The prognostic impact of this adverse genetic profile was independent of MRD status on day +35 of induction therapy. Both variables allowed risk-stratification of T-ALL into standard or high-risk groups with significantly different 5-year overall survival (OS) (95% confidence interval [CI]) of 52% (37-67 %) and 17% (1-33%), respectively. These results confirm the relevance of the tumor genetic profile in predicting patient outcome in adult T-ALL and highlight the need for novel gene-targeted chemotherapeutic schedules to improve the OS of poor-prognosis T-ALL patients.
Evaluation of Porcine Somatic and Testicular Germ Cells During Differentiation and Proliferation
Authors: Tabar Amirreza Niazi , Azizi Hossein , Roshan Mehdi Mehdinezhad , Alipour Hiva
Published: February 2022

Background: Spermatogenesis is the complex process of sperm production to transmit paternal genetic information to the subsequent generation. This process is determined by the collaboration of several germ and somatic cells, most importantly spermatogonia stem cells and Sertoli cells. To characterize germ and somatic cells in the tubule seminiferous contort in porcine and consequently has an impact on the analysis of porcine fertility.Materials and methods: Germ cells were extracted from porcine testis by enzymatic digestion before being expanded on Sandos inbred mice (SIM) embryo-derived thioguanine and ouabain-resistant fibroblasts (STO) feeder layer supplemented with FGF, EGF, and GDNF. Immunohistochemistry (IHC) and immunocytochemistry (ICC) analysis for Sox9, Vimentin, and PLZF markers were performed to examine the generated colonies of porcine testicular cells. Electron microscopy was also utilized to analyze the morphological features of the extracted porcine germ cells.Results: IHC analysis revealed that Sox9 and Vimentin were expressed in the basal compartment of the seminiferous tubules. Moreover, ICC results showed that the cells have low expression of PLZF while expressing vimentin. Heterogeneity of the in vitro cultured cells was detected via morphological analysis by the electron microscope. Conclusion: In this experimental study, we tried to reveal the exclusive information which obviously could be helpful for future success in achievement to proper therapies against infertility and sterility as an important global issue.
The Illumination Problem In Open Systems: Observation Of A Half-Illuminated Mode In A Penrose Cavity
Authors: An Kyungwon , Kim Juman , Kim Jinuk , Seo Jisung , Park Kyu-Won , Moon Songky
Published: February 2022

The illumination problem in mathematics questions the existence of a bounded region in which light rays from a point light source do not illuminate the whole region. Since R. Penrose disproved the illumination problem with elliptical reflective boundaries, the interest has mostly remained in ray optics mainly because there can be no completely dark region for light waves due to diffraction. Here, in a two-dimensional Penrose cavity with elliptical boundaries, we report experimental observation of a symmetry-broken mode in the long-wavelength regime with the half of the cavity region with reflection symmetry almost unilluminated in the steady state. The half-illuminated mode (HIM) was observed in an acoustic cavity by using the schlieren method. The HIM originated from the coherent superposition of near-degenerate modes, among which two scarred modes with opposite parities played a major role. The illuminated part of the HIM could be even flipped by choosing different coefficients in the coherent superposition of the participating modes. The HIM of the Penrose cavity provides new perspective to the illumination problem in an open system.
Artificial Weathering of Rock Types Bearing Petroglyphs from Murujuga, Western Australia
Authors: Neumann Jolam T , Black John L , Hoerlé Stéphane , Smith Benjamin W , Watkins Ron , Lagos Markus , Ziegler Alexander , Geisler Thorsten
Published: February 2022

Murujuga in Western Australia has the largest concentration of ancient rock engravings (petroglyphs) in the world. However, the Murujuga rock art is potentially threatened by local industrial air pollution, in particular by acid rain, but unambiguous scientific evidence is still missing. Here, we report on results of an accelerated weathering experiment, simulating Murujuga weather and climate conditions that was designed and performed to test whether the expected small changes in chemical, mineralogical, and physical characteristics of the rock surface can be detected and reliably quantified by various analytical means. Locally acquired Murujuga granophyre and gabbro samples with natural varnish were artificially weathered for up to four months in a climate chamber under conditions that simulated two years of natural weathering. Mineralogical, chemical, and physical changes were qualitatively monitored by X-ray diffraction and confocal Raman spectroscopy, and quantified by colorimetry, portable X-ray fluorescence spectrometry, and micro-computed tomography. In addition, artificial rainwater that was sprinkled over the rock samples was collected and analysed by inductively-coupled plasma mass spectrometry. The results show significant chemical and physical changes of the surfaces of the rock varnish after one month of artificial weathering. The analytical results demonstrate that it is possible to quantitatively monitor small changes caused by the weathering of gabbro and granophyre. Therefore, such a semi-actualistic experimental approach, when carefully designed, potentially allows testing the hypothesis that the weathering rate of the Murujuga petroglyphs is increased by local industrial air pollution. Further experimental work is currently under way.
Critical effect of reaction pH on the microstructural, optical and electrical behavior of ZnO/CuO hetero-structured nanocomposite films
Authors: ER Irmak KARADUMAN , Ajjaq Ahmad , Ateş Aytunç , Acar Selim
Published: February 2022

CuO nanocomposite films and ZnO/CuO nano-heterostructures were synthesized by a series of chemical reactions at different pH values based on the hydrothermal and SILAR (successive ionic layer adsorption and reaction) methods. The ultimate purpose of this work is to explore the impacts of solution pH value and ZnO-based heterostructure on the structural, optical and electrical features of CuO films using X-ray diffraction (XRD), Raman spectroscopy, scanning electron microscopy (SEM), energy-dispersive X-ray analysis (EDX), transmittance spectrum, current-voltage (I-V) measurements and capacitance-conductance (C-G) measurements in 300–600 K temperature range and 20 Hz–1.5 MHz frequency range. XRD analysis revealed that the crystallite size and strain lattice parameters decrease with the increase in pH value without affecting the crystalline structure of the synthesized films. SEM images revealed the regular growth of ZnO structure without any deterioration in the CuO substrate layer where an increase in the thickness of the formed rods was observed with the increase in reaction pH value. Transmittance dropped greatly with the formation of heterojunction from about 40% (for CuO) to about 1% (for ZnO/CuO) in the visible range followed by a crystallite size-induced change in bandgap from 2.29 eV to 2.32 eV (for CuO) and from 2.03 eV to 2.11 eV (for ZnO/CuO). The increase in pH from 11.0 to 11.2 increased the room-temperature resistance of ZnO/CuO composites from 377 MΩ to 474 MΩ, the ideality factor from 4.41 to 4.68 and the barrier height from 0.74 eV to 0.83 eV. It can be deduced that reaction pH value is an important synthesis parameter that can tune the structural, morphological, optical and electrical properties of ZnO/CuO nanocomposite films for advanced industrial or technological implementations by controlling the nucleation and crystal growth rates during chemical synthesis processes.
FIB-4 as a non-invasive marker in predicting fatty liver in select populations from Tamil Nadu State.
Authors: Varanasi Bhargav , Alen Tom , Mu Karthikeyan , Selvan Thamarai S , Venkataraman Jayanthi
Published: February 2022

Background: FIB 4 score is known to have a significant negative and positive predictive value in predicting lower and higher grades of liver fibrosis. Aim: To determine the cut off of FIB-4 in patients with a normal ultrasound and in those with Fatty Liver (all grades) as a predictor of fibrosis. Methods: Prospective data on hemogram, liver biochemistry and ultrasound (USG) were collected in Master Health Check (MHC). USG findings were classified as normal Grade 1, 2 and 3 FL.FIB-4 were calculated. Patients with known liver disease were excluded. Statistical Analysis: Appropriate non parametric tests were used. AUROC was obtained for FIB-4 cut off. SPSS version 23v was used. Results: There were 741 subjects (274 men; 64%). 418 (56.4%) were > 45 years. Liver was normal in 297 (40.1%); grade 1, 2 and 3 FL in 293 (39.5%), 114 (15.4%) and 37 (5%) subjects respectively. The overall mean FIB-4 score was high in males (1.37 ± 1.06 vs 1.15±0.83, p value 0.009) and remained so for age > 45 years (1.69+ 1.09 versus 1.33+ 0.88, p value 0.000). Mean FIB-4 scores increased with grades of FL (p 0.126). AUROC was 0.538, 0.516 and 0.602 respectively for Gr 1, 2 and 3 respectively. Conclusion: FIB-4 score in our study is lower than that reported in the west with poor prediction for any grade of FL.
Reference Values For Diaphragm Electrical Activity (Edi) In Newborn Infants
Authors: Gurumahan Varappriyangga , Thavalingam Sriganesh , Schindler Tim , Smyth John , Lui Kei , Bolisetty Srinivas
Published: February 2022

Background: Neurally adjusted ventilatory assist is an emerging mode of respiratory support that uses the electrical activity of the diaphragm (Edi) to provide synchronised inspiratory pressure support, proportional to an infant's changing inspiratory effort. Data on Edi reference values for neonates are limited. The objective of this study was to establish reference Edi values for preterm and term neonates.Methods: This was a prospective observational study of newborn infants breathing spontaneously in room air. The Edi signal was monitored by a specialised intragastric feeding tube with embedded electrodes positioned at the level of the diaphragm. Edi minimums and peaks were recorded continuously for four hours.Results: 24 newborn infants (16 preterm [<37 weeks’ gestation]; 8 term) were studied. All infants were breathing comfortably in room air at the time of study. Edi data were successfully captured in all infants. The mean (±SD) Edi minimum was 3.02 (±0.94) µV and the mean Edi peak was 10.13 (±3.50) µV. In preterm infants the mean (±SD) Edi minimum was 3.05 (±0.91) µV and the mean Edi peak was 9.36 (±2.13) µV. In term infants the mean (±SD) Edi minimum was 2.97 (±1.05) µV and the mean Edi peak was 11.66 (±5.14) µV. Conclusion: Reference Edi values were established for both preterm and term neonates. These values can be used as a guide when using diaphragm-triggered modes on respiratory support in newborn infants.
Metformin prevents the psoriasis under hyperlipidemia via activation of the FOXO3
Authors: Li Chengxin , Zhang Li , Liu Xiaoling , Huang Min , Wang Rui , Zhu Wenwei , Li Yu , Shen Lin , Xie Fang , Wang Wenjuan , Song Cuihao , Tang Zijie
Published: February 2022

Background: Psoriasis patients have obvious lipid metabolism disorders. The hyperlipidemia aggravates the development of psoriasis. In this study, we investigated that under the hyperlipidemia conditions, whether metformin could alleviate psoriasis via a Forkhead box O 3 (FOXO3)-driven pathway, as well as the mechanisms underlying. Methods: Wild type or FOXO3 knockdown HaCat cells were treated with free fatty acids (FFA) for 10 days and then co-treated with metformin for another 4 days. Triglyceride (TG) level, cell viability, proliferation, apoptosis, antioxidant enzymes, ROS levels, as well as the transcription activity of FOXO3 were analyzed. Results: Our data showed that FFA treatment promoted the proliferation and inhibited the apoptosis in HaCat cells. However, metformin could reversed all of these changes. Metformin treatment significantly increased the expressions and the activities of superoxide dismutase (SOD) and catalase (CAT), and reduced the reactive oxygen species (ROS) level, while FFA inhibited the antioxidant enzymes and increased the ROS level in HaCat cells. Metformin significantly promoted the autophagy and increase FOXO3 protein level in the nucleus under hyperlipidemia conditions, which was significantly inhibited by FFA treatment. However, all of the effects from metformin were partially blocked by FOXO3 knockdown. Conclusion: This study demonstrated that under the hyperlipidemia conditions, metformin has significant antiproliferation and proapoptosis effects by reducing ROS level as well as increasing autophagy. Both of these were responsible for the alleviation of psoriasis. All of these effects from metformin were through FOXO3-dependent pathway.
Subacute Effects of Vaccination with a Messenger RNA-based Vaccine Against Coronavirus Disease 2019 on Elderly Japanese Patients with Cardiac Disorder
Authors: Tamimoto Ryuichi , Fujii Toshiharu , Nagamatsu Hirofumi , Murakami Tsutomu , Miyazaki Koji , Goto Shinya , Cho Yasunori , Mori Hidezo
Published: February 2022

The present observational study assessed the occurrence of adverse cardiac events following vaccination of patients (n = 100) with an mRNA-based vaccine against coronavirus disease 2019 (COVID-19). Death and deterioration of heart failure were evaluated as side effects. The status of heart failure was assessed using the brain natriuretic peptide (BNP) ratio, for which the BNP or NT-pro BNP values were divided by their upper normal limits (UNL); values (i.e., post-BNP levels minus pre-BNP levels) ≥ 10-fold higher than the UNL denoted significant increment. Here we show that vaccination with an mRNA-based vaccine against COVID-19 was associated with a high risk of death or decompensated heart failure for elderly patients with a BNP ratio ≥ 4-fold higher than the UNL. Six and 15 patients expired and exhibited significant increment of the BNP ratio, respectively; these patients had a pre-BNP ratio ≥ 4-fold higher than the UNL. Forty-five patients with a pre-BNP ratio < 4-fold higher than the UNL did not expire or show significant increase in the BNP ratio. The pre-BNP ratio was a reliable parameter for predicting cardiac deterioration after vaccination. For the booster or initial vaccination against COVID-19, the BNP ratio may be useful in assessing the cardiac status of elderly patients.
Performance evaluation of mixed-halide perovskites in p-i-n solar cells with a monolayer-based hole transport layer
Authors: Murdey Richard , Ishikura Yasuhisa , Matsushige Yuku , Truong Minh Anh , Nakamura Tomoya , Wakamiya Atsushi
Published: February 2022

The efficiency and operational stability of p-i-n perovskite solar cells fabricated with a molecular monolayer, MeO-2PACz, as the hole transport material are assessed for two triple-cation mixed halide lead perovskite compositions. The performance of a wide bandgap formula with high Br content (Br/I ratio 1:2, bandgap 1.72 eV) is compared against a reference narrow bandgap formula with low Br content (Br/I ratio 1:11, bandgap 1.57 eV). The stable output after 100 h operation under simulated sunlight and a 3-week recovery period is 19.1% for the low-Br device and 16.6% for the high-Br device. The open circuit voltages are 1.07 V and 1.16 V, respectively. Operation in low light is stable, with the high-Br device achieving 30% power conversion efficiency under a white LED at 250 µW cm− 2 irradiance (835 lx). Overall, our findings confirm the wide bandgap, high-Br monolayer-based p-i-n device to be a reliable and efficient candidate for ambient light harvesting.
Techniques, Challenges and Future Prospects for Cell-based Meat
Authors: Upadhyay Rituja , Benny Anmariya , Pandi Kathiresan
Published: February 2022

The food industry has come up with a wide range of innovations, changes, and possibilities to create meat through in vitro conditions as a result of a proportionally expanding population and food demands. This breakthrough has the potential to completely transform the meat business, with far-reaching repercussions for the environment, human health, and animal welfare. Thus, animal cells rather than slain animals are used to make cell-based meat, where the proliferation and differentiation of the cells take place in the culture media. The main purpose of this paper is to analyze the overall mechanism and various techniques involved in cell-based meat production. It also discusses upcoming challenges such as technical, consumer, regulatory aspects, environmental issues, product costs, the economy, health safety concerns, ethical, religious, and social taboos. Finally, it analyzes the prospects of the cell-based meat production technique.
Tonic down-rolling and eccentric down-positioning of eyes under general anaesthesia: Case series and review of Literature
Authors: Chaurasia Shweta , Soni Shiv Lal , Ram Jagat , Sukhija Jaspreet , Chaurasia Swati , Takkar Aastha , Rasal Abhijit
Published: February 2022

Background. Unexpected tonic down-rolling and eccentric down-positioning of eyes during general anesthesia can have serious implications in ocular surgeries.Objectives. To summarize abrupt eccentric eye positioning in downgaze following the downward movement of eyes encountered in patients undergoing ophthalmic surgeries under general anesthesia (GA) and analyze the relationship between the fluctuation in the depth of anesthesia (DOA) and eccentric eye positioning. Subjects and Methods. Patients undergoing ophthalmic surgeries under GA without nondepolarizing muscle relaxant between January 2018-December 2019 in a tertiary-eye-care who witnessed a sudden tonic downward movement of eyes were included in the retrospective case series. Results. A total of 9 patients out of 199 were enrolled in this study with a median (IQR) age of 1.1years (0.79-1.5). All cases were performed under GA with sevoflurane as an inducing agent. Downward movement was seen before the start of surgery in 4 cases and during surgery in 5 cases. Downward drift of eyes appeared tonic as a strong tug was felt in an extreme downward eccentric position. It was preceded by an eccentric upward drift of eyes in 5 cases Downward movement was quick but return movement of eyes to the central position was gradual (median 1.5 minutes). Median (IQR) MAC and eye position/score in 9 cases at the time of eccentric movement in downgaze was 1.62 (1.4-1.8) and -4 (-4 to -2.5) respectively while median (IQR) MAC at the time of centralized position was 1.3 (1.2-1.4). BIS values in two cases corroborated elevated and downward eye positions with lighter and deeper DOA respectively. A strong negative correlation was seen between DOA and eccentric eye position (r=-0.89, p=0.000).Conclusions. Tonic-downward movement of eyes or its eccentric positioning in downgaze is not an uncommon entity in children under GA without muscle-relaxant and fluctuations in DOA should be avoided to circumvent inadvertent complications during ocular surgery.
Multi Station Approximation and Noise Mitigation Process to OFDM Systems Using Successive JCI
Authors: Devi N P SARADA
Published: February 2022

The performance of OFDM systems can be sharply deteriorated with effect of impulsive noise. It’s proposed in this paper about the combined station impulse reaction approximation& impulsive noise mitigation-process on the basis of compressed-sensing concept. From these algorithms, we can treat channel impulsive responses & impulsive noise as joint sparse-vector. Thereafter, framework of sparse-Bayesian learning is utilised for helping estimating the station-impulse responses, impulsive noise & data signs. Here, data sign can be known as the unknown parameter. The Cramer Rao Lower Bound’s elaborated as the bench-mark. From all used impulse noise- mitigation techniques, proposed procedure in the paper can be used with the sub-pilot by not using past info of the station& impulsive-noise. The model outcomes conclude at the process projected in the paper improves the efficiency in the station approximation& enhances performance of bit error rate.
Financial development, heterogeneous technological progress, and carbon emissions: Empirical analysis based on Provincial Panel Data in China
Authors: Liu Renzhong , Du Jingxiu
Published: February 2022

Global warming, caused by an increase in carbon emissions, is a phenomenon that has attracted considerable attention worldwide. Financial development affects technological progress and carbon emissions. Based on the provincial panel data of 30 provinces and cities in China from 2006 to 2018, combined with the heterogeneity of technological progress, this study constructs an intermediary effect model for empirical analysis. Combined with different regional characteristics in the east, middle, and west of China, this study explores the impact of financial development on carbon emissions and the transmission path of heterogeneous technological progress as an intermediary variable. The results show that at the national level, in the eastern and central regions, the relationship between financial development and carbon emissions conforms to the characteristics of Environmental Kuznets curve, and the relationship between financial development and carbon emission in the western region increases linearly. Among the intermediary effect transmission paths of heterogeneous technological progress, generalised technological progress, environmental technological progress, energy technological progress, capital embodied technological progress and FDI technology spillover are the transmission paths of financial development on carbon emissions at the national level. However, after the regional division of the east, middle, and west, heterogeneous technological progress shows different carbon emission reduction effects. Through quantitative analysis, this study provides reference suggestions for financial development to help reduce carbon emissions, to prevent the emergence of ‘one size fits all’ technology policy or regional overall planning concept.
Methodologischer Entwurf eines komparativen Analyseverfahrens mit Hilfe der Grounded Theory
Authors: Könitz Christopher
Published: February 2022

Nachdem ich das zu Grunde liegende Forschungsinteresse skizziert habe, soll es in diesem Kapitel um die Frage gehen, wie eine komparative Analyse mittels der Strukturalen Medienbildung ermöglicht werden kann. Hierzu werde ich eingangs die grundlegenden methodologischen Prämissen der Strukturalen Medienbildung darstellen. Anschliessend werde ich die strukturale Computerspielanalyse, als einer der zentralen Methoden dieser Arbeit, herausarbeiten. Dabei werde ich es nicht nur bei einer reinen Darstellung dieser Methode belassen, sondern werde methodologische und methodische Erweiterungen vornehmen, die einen Teil der Ergebnisse dieser Arbeit widerspiegeln. Der zweite Teil dieses Kapitels widmet sich der Grounded Theory Methodology (GTM) und deren Entwicklungen. Hierbei werde ich vor allem Gemeinsamkeiten sowie methodische, wie auch methodologische Unterschiede, in den Entwicklungslinien der GTM hervorheben. Diese Darstellung soll dazu dienen um im dritten Teil des Kapitels, die Strukturale Medienbildung mit der Grounded Theory Methodology zu kombinieren. In diesem Teil geht es einerseits um die Herausarbeitung methodologischer Bezugspunkte und andererseits um die methodische Integration der beiden Ansätze.
Street language in Dùndún Drum Language
Authors: Oludare Olupemi
Published: February 2022

Dùndún drum language is a practice of speech surrogacy employed by dùndún drummers in Yoruba culture. The dùndún drummers play sequences of melo-rhythmic patterns; a form of communication that employs musical and linguistic elements, comprehensible to listeners knowledgeable in the Yoruba language. Although these sequenced patterns are sourced from Yoruba everyday sentences and oral genres (proverbs, poetry, praise-chants, and idiomatic phrases), the drummers also embrace other social narratives. These include the popular linguistic expressions in public spaces referred to as “street language.” This is because the streets serve as spaces for social life, musical and cultural imaginaries, musical and language expressions, and identity. This street language, referred to as “ohùn ìgboro” in Yoruba, include slang (saje), slurs (òtè), neologies (ènà), satire (èfè), dance-drum patterns (àlùjó), and socio-political slogans (àtúnlò-èdè). This article explores the influence of street language on dùndún music. This article follows an ethnographic model, with an analysis of the content of the dùndún music and its associated texts. The article’s findings include the extent to which the two cultures have overlapped, and the various socio-cultural benefits of adopting the language of each other’s cultural practices. In the process, the article contributes to the debate on authenticity and social structure in Yoruba culture. The article emphasises the need for an integrated research approach of music and language and their interrelationship to street cultures in Nigeria.
Thermal Management of Small-Scale Li-ion Battery Module Using Graphite Matrix Composite with Phase Change: Effect of Discharge Rate
Authors: YAZICI Mustafa Yusuf
Published: February 2022

An experimental study is performed to investigate the performance (thermally and electrically) of a small-scale li-ion module (3s2p) using passive thermal management strategy of phase change material (PCM)/graphite matrix. The PCM/graphite matrix was obtained by impregnating the graphite matrix (bulk density: 75 g L-1) with phase change material (paraffin/organic, RT-35). The performance tests of a li-ion module are conducted at 1C and 1.6C discharge rates for graphite matrix composite with phase change (phase change composite or PCM/graphite matrix) and also air cooling, comparatively. To illustrate the performance of the PCM/graphite matrix, transient temperature variations, thermal imaging, discharge capacity, and energy capacity are achieved comprehensively. The results illustrate that graphite matrix composite with phase change has a significant contribution to melting heat transfer, operating temperature, utilized capacity, and energy capacity compared to air cooling. Effective thermal conductivity of PCM/graphite matrix is increased 35 times by comparison with pure paraffin. Operating temperature and temperature gradient throughout the li-ion surface decrease by 22 % and 43 % compared to the air cooling, respectively, for high discharge rate. Operating time and energy capacity is increased 33 % and 28% compared to natural air cooling, respectively, for high discharge rate. It is also disclosed that dominant heat transfer mechanism is conduction depending on micro/nano-size porous structure of graphite matrix.
Organik Ürün Pazarındaki Tüketicilerde Organik Ürün Bilinci: İstanbul ve İzmir İlleri Örneği
Authors: ŞAHİN Ayça Nur , YERCAN Murad
Published: February 2022

Bu araştırmada, organik ürün pazarına gelen tüketicilerin organik ürün bilincini ölçmek amaçlanmıştır. Bu amaç kapsamında, İzmir ve İstanbul’da ki organik ürün pazarlarında 271 tüketici ile yüz yüze anket yapılmıştır. Anket analiz sonucunda organik pazara gelen organik ürün tüketicilerinin çoğunlukla orta yaşlı, evli, kadın ve yüksek eğitim seviyelerinde olduğu belirlenmiştir. Yapılan anketler sonucunda organik ürün pazarlarına gelen tüketicilerin %97.8’i organik tarımın ne olduğunu bildiklerini beyan etmişler ve bunlardan %97.7’si ise organik tarımı doğru tanımlayabilmiştir. Çalışma kapsamındaki organik tüketicilerin organik ürünlerle ilgili bilgi kaynaklarının genellikle internet ve sosyal medya olduğu (%45.4) ve bunu takiben aile ve arkadaş çevresinin de (%33.6) bilgi ediniminde etkili olduğu ortaya konmuştur. Bu kapsamda organik ürün tüketimini arttırmaya yönelik; organik tarım, organik ürün, organik ürün sertifikaları ve organik ürün pazarlarıyla ilgili yapılacak olan bilgilendirme, tanıtım gibi konularda internet ve sosyal medyanın daha etkili bir yöntem olacağı belirlenmiştir. Çalışma sonucunda organik ürün pazar sayısının Türkiye genelinde arttırılması, organik ürün tüketimini arttırabileceği ve uzun vadede ise üretim miktarlarını, üretici sayısını, üretim alanlarını ve dolayısıyla ithalat ve ihracat miktarlarını pozitif yönde etkileyeceği düşünülmektedir.
Derin Öğrenme Modeli ile Yüz İfadelerinden Duygu Tanıma
Authors: AKAR Funda , AKGÜL İsmail
Published: February 2022

Yüz ifadesinden duygu tanıma; insan-bilgisayar etkileşimi, duygusal hesaplama vb. gibi birçok bilgisayarla görme alanında uygulanabilen güncel bir araştırma konusudur. Bu çalışmada, KDEF ve PICS veri setleri kullanılarak derin öğrenme ile duygu tanımaya yönelik bir uygulama yapılmıştır. Öznitelik çıkarımı için derin öğrenme tekniklerinden olan ve yapay sinir ağları içeren bir yapay zekâ yaklaşımı olan Evrişimsel Sinir Ağı (ESA) kullanılarak yeni bir model geliştirilmiştir. Derin öğrenmenin yüksek başarımı için büyük veri setine ihtiyaç duyulmaktadır. KDEF veri setinde 4900, PICS veri setinde 322 görüntü bulunmaktadır. Bu amaçla öncelikle PICS veri setindeki görüntü sayısının az olmasından dolayı veri artırma yöntemi ile görüntü çoğaltma işlemi uygulanmıştır ve PICS veri seti 4830 görüntüye çıkarılmıştır. Daha sonra bu iki farklı veri seti üzerinde ayrı ayrı eğitim gerçekleştirilerek geliştirilen yeni model test edilmiştir. ESA modellerinden olan VGGNet temel alınarak geliştirilen yeni model ile gerçekleştirilen çalışmada, her bir veri setinde yedi farklı duygu sınıfı (korku, öfke, iğrenme, mutluluk, nötr, üzüntü, şaşırma) ele alınmıştır. Geliştirilen model ile KDEF veri setinin geçerleme kümesinde %97.44, PICS veri setinin geçerleme kümesinde %98.24 doğruluk değerleri elde edilerek yüksek bir başarı oranına ulaşılmıştır.
Factors constraining household willingness to pay for piped water tariffs: the case of Ekiti State, Nigeria
Authors: Adeoti O. , Fati B. O.
Published: February 2022

One of the major problems confronting public water utilities in Nigeria is how to realise effective piped water tariff revenues collection. This study was therefore conducted to identify the major factors constraining household willingness to pay for piped water tariffs in Nigeria, using Ekiti State as a case study, and possible interventions which might help to improve the situation from the perspective of piped water customers. A tested survey has been used through a representative sampling process. The research findings were checked with additional data from relevant literature and legal documents. Findings revealed that political promise, availability of other water sources, lack of recognition of drinking water as a human right, inadequate method of collecting tariff revenues, and poor response to complaints were the major factors constraining household willingness to pay for piped water tariffs in the studied case in Nigeria. The suggested major possible interventions which might help to improve the situation include the installation of water meters, instituting a customer consultative forum, as well as putting in place improved customer relations. To be effective, it is crucial that public water utilities in Nigeria incorporate these factors into piped water supply decision-making and policy measures.
Importance of Indazole against Neurological Disorders
Authors: Pal Dilipkumar , Sahu Pooja
Published: February 2022

Indazole is a nitrogen-containing bicyclic compound, having three tautomeric forms: 1Hindazole,
2H-indazole, and 3H-indazole. Mostly, they are considered as 1H-indazole tautomeric
forms, although they have the potential to tautomerism to 2H- and 3H-indazole forms. Indazoles are
involved in a wide variety of biological and enzymatic processes. Therefore, they exhibit a series of
pharmacological activities. Indazoles show potent activities against neurological disorders such as
Parkinson's disease (PD), Alzheimer's disease (AD), mood disorders, etc., by inhibiting different
signaling pathways and the generation of neurotransmitters and activation of enzyme activity. They
effectively prevent neurological diseases by different mechanisms, such as by inhibiting the monoamine
oxidase (MAO) and kinase enzymes like Glycogen synthase kinase 3 (GSK3), and leucinerich
repeat kinase enzyme 2 (LRRK2). In this article, we have discussed multiple causative strategies
of indazole to treat neurological diseases. This has aroused special attention in the discovery of
the novel indazoles and their biological activities.
Trending: A Systematic Review of Social Media Use’s Influence
on Adolescent Anxiety and Depression
Authors: Damodar Sreedevi , Lokemoen Cidney , Gurusamy Vikram , Takhi Manpreet , Bishev Daniel , Parrill Allison , Deviney Melissa , Person Ulziibat , Korie Ijendu , Branch Romain
Published: February 2022

Background:

With new technological advancements, adolescents can obtain
devices that give them virtually unlimited access to social media (SM) which may impact
adolescent mental health.

Objectives:

This literature review aims to evaluate the influence of social media use on
adolescent anxiety and depression.

Methods:

A literature search of PubMed from June 2010 through June 2020 was completed
for the following MeSH terms: social media, adolescent, anxiety, depression, and mental
health. English language articles that discussed adolescents aged 13 to 18 years, anxiety
and/or depression and SM were included. Extracted data included the SM platform, impact
on anxiety and depression, interventions, temporal and dose-response relationships, and
observed versus self-reported usage.

Results:

The majority of articles positively associated depression (82.6%) and anxiety
(78.3%) with SM use. depression corresponded with cyber-bullying (42.1%), negative
social perspective (21.0%), diminished self-esteem (15.8%), and sleep disturbance (10.5%).
Anxiety corresponded with a negative social perspective (44.4%), diminished self-esteem
(33.3%), sleep disturbance (16.7%), and cyber-bullying (16.7%). Many studies suggested
the use of interventions to reduce depression (72.7%) and anxiety (72.7%), such as screen
time restrictions (n=6) and social support (n=4), but lacked evaluation of their
implementation.

Conclusion:

Current literature suggests a positive association between adolescent SM use
with anxiety and depression. Our study highlights the need for further investigation of
temporal and dose-response associations between SM use and adolescent mental health, and
the potential benefits of SM-driven interventions.
AİLE HEKİMLİĞİ POLİKLİNİĞİNE BAŞVURAN BİREYLERİN SAĞLIK ALGISI VE SAĞLIKLI YAŞAM BİÇİMİ DAVRANIŞLARININ DEĞERLENDİRİLMESİ
Authors: OLGUN Zeynep , KUTLU Ruhuşen
Published: February 2022

Amaç: Bu çalışmada, Necmettin Erbakan Üniversitesi Meram Tıp Fakültesi Aile Hekimliği Polikliniğine başvuran bireylerde sağlık algısı ve sağlıklı yaşam biçimi davranışlarının değerlendirilmesi amaçlanmıştır. Gereç ve yöntem: Kesitsel tipteki bu analitik çalışma, polikliniğimize herhangi bir nedenle başvuran 480 katılımcıda yapılmıştır. Veriler sosyodemografik bilgiler, Sağlık Algısı Ölçeği (SAÖ) ve Sağlıklı Yaşam Biçimi Davranışları Ölçeği-II (SYBDÖ-II) kullanılarak toplanmıştır. Bulgular: Katılımcıların yaş ortalaması 35,1±10,7 yıl, %53,7’ si kadın, %65,2’si evli, %55,6’sı üniversite mezunu idi. SAÖ toplam puanı evli olmayan katılımcılarda anlamlı olarak daha yüksek idi (p<0,038). Öz farkındalık ve sağlığın önemi alt boyutlarından aldıkları puanlar erkeklerde kadınlara göre daha yüksekti (p=0,006, p=0,037). Kontrol merkezi, kesinlik ve toplam puan ortalama değerleri üniversite eğitimli olan grupta daha yüksekti (p<0.001). Yaş gruplarına göre SYBDÖ-II beslenme alt boyut puan ortalaması 34 yaş ve üzerinde olan katılımcılarda anlamlı olarak daha yüksek bulunmuştur (p=0,011). SYBDÖ- II kendini gerçekleştirme alt boyut puan ortalaması erkeklerde anlamlı olarak daha yüksek idi (p=0,027). SYBDÖ-II ortalamalarının 125,6±20,3 puan olduğu ve en yüksek alt boyut puanının kendini gerçekleştirme, en düşük alt boyut puanının ise fiziksel aktivite alanında olduğu saptandı. SAÖ ortalamaları 48,2±6,3 puan olarak bulunmuş, alt boyutlarından ise en düşük puan öz farkındalık, en yüksek puan ise kontrol merkezi alt boyutundan alınmıştır. SYBD puanları kronik hastalığı olan, sürekli ilaç kullanan ve kanser taraması yaptıran grupta anlamlı olarak daha yüksek bulunmuştur. Sonuç: Kronik hastalık olmaması, sağlık algısını olumlu yönde etkilerken, kronik hastalığı olanlarda SYBD puanları daha yüksek bulunmuştur. Toplumu bu konuda yönlendirecek olan aile hekimlerinin hastalarına SYBD'ları hakkında farkındalığı artırıcı eğitim ve danışmanlık hizmeti vermesi önemlidir.
Nomofobi ile Fiziksel Sağlık Sorunları arasında Bir İlişki var mıdır?
Authors: DEMİR GÖKMEN Burcu , FIRAT Meryem , CENGİZ Mine , KANBAY Yalçin
Published: February 2022

Amaç: Araştırma toplumda akıllı telefon kullanan bireylerde nomofobi ile fiziksel sağlık sorunları arasındaki ilişkiyi incelemek amacıyla yapılmıştır. Yöntem: Tanımlayıcı tipte tasarlanan araştırma Kasım- Aralık 2020 tarihleri arasında yapılmıştır. Araştırmanın evrenini Ağrı il merkezinde yaşayan bireyler, örneklemini ise kolayda örnekleme yöntemi ile ulaşılabilen 746 kişi oluşturmuştur. Veriler “Kişisel Bilgi Formu” ve “Nomofobi Ölçeği” kullanılarak toplanmıştır. Verilerin analizi SPSS-25 paket programında yapılmış olup, önemlilik düzeyi p<0,05 olarak kabul edilmiştir. Bulgular: Araştırmaya katılan bireylerin yaş ortalamasının 32,63±11,31 olduğu, %63,0’ünün kadınlardan oluştuğu ve %31,5’inin günlük olarak 5 saatten fazla telefon kullandığı bulunmuştur. Katılımcıların orta düzeyde nomofobik olduğu bulunmuştur. Yaşın, günlük telefon kullanım süresinin ve çeşitli fiziksel sorunlar (Baş ağrısı, uykusuzluk, sinirlilik, yorgunluk, bel boyun sırt ağrısı ve göz ağrısı) yaşamanın nomofobi üzerinde etkili olduğu belirlenmiştir (p<0,05). Sonuç: Toplumda nomofobi önemli bir sorundur. Katılımcıların akıllı telefon kullanımına bağlı olarak yaşadıkları nomofobi düzeyi fiziksel sağlık sorunlarını etkileyebilmektedir. Nomofobi ile başa çıkmak için akıllı telefonla geçirilen süre kısaltılmalı ve bilinçli telefon kullanımını artıran girişimler yapılmalıdır.
How to Best Understand the Changing Online Social Contract
Authors: Macdonald Kathy
Published: February 2022

On November 25, 2021, Kathy Macdonald (M.O.M.), former Calgary Police officer, presented on How to Best Understand the Changing Online Social Contract at the 2021 CASIS West Coast Security Conference. The presentation was followed by a question and answer period and a breakout room session with questions from the audience and CASIS Vancouver executives. The key points discussed included the knowledge, skills, and abilities required for police work in dealing with forensic cyber investigations and processing digital evidence, as well as building community relationships.
Charyzmaty w życiu św. Jana Bosko na tle posoborowej teologii charyzmatu
Authors:   Uniwersytet Papieski Jana Pawła II w Krakowie, Figura Paweł
Published: February 2022

The article connects the post-conciliar teaching of the charisms with their manifestation in the life of St. John Bosco. The reading and analysis of the post-conciliar doctrine of the charisms and the available Salesian sources have made it possible to reflect theologically on the spiritual gifts of St. John Bosco. The criteria for the authenticity of the charisms were applied in the article. The Charisms of the Saint are presented in an ecclesial or hierarchical order. Moreover, the charisms present in the life of the saint have been analyzed as extraordinary phenomena, the subject of research in the theology of interior life.
Dzieje „Księżówki” Ewangelicko-Augsburskiej w Wiśle
Authors:   Akademia Wychowania Fizycznego Józefa Piłsudskiego w Warszawie, Piekarski Stanisław
Published: February 2022

The regaining of independence by Poland in 1918 gave rise to great hopes. Very quickly it turned out that one of the most important tasks to be accomplished, was to improve the health of the Polish nation damaged by prolonged war and years of partitions. Sanatoriums, health houses and holiday homes had to be built urgently. The state was counting on the help of Poles, especially those who had a fixed income. In such circumstances, in the early twenties of the twentieth century already, teachers, military personnel, police officers, railwaymen, postal workers and other professional groups set up associations and foundations whose purpose was to build and then maintain (on a voluntary basis taxation) all types of health and recreation resorts. Priests of different religions also participated in this social process. The purpose of this article is to present the circumstances of construction and the effects of the activity of the Evangelical-Augsburg “Księżówka” opened in the summer of 1934 in Wisła. With the outbreak of World War II, “Księżówka” was taken over by the German administration. After the war, the resort has been “nationalized”. At first, local high schools operated there, and then a guest house for the Voivodship Committee of the Polish United Workers' Party was established. It was only in 1991 - after strenuous efforts - when Evangelical-Augsburg “Księżówka” returned to their rightful owners