bluuebunny/crossref_metadata_2025 huggingface dataset:
The Role of Diagnostic Models in Prejudice Toward People With Borderline Personality Disorder: An Experimental Investigation
Authors: Wai Nicholas , Bizumic Boris , Monaghan Conal , Sheppard Hannah , Greenwood Lisa-Marie
Published: October 2024

We tested whether dimensional personality disorder models such as the Alternative Model for Personality Disorders (AMPD) cause less prejudice toward people with borderline personality disorder (BPD) than categorical models, and we sought to identify the mechanisms underpinning this reduction in prejudice. Undergraduate psychology students (n = 183) were randomly assigned to one of three conditions (AMPD, categorical, control) and given descriptive information about BPD. Participants in the AMPD and categorical conditions also received a presentation about their respective BPD diagnostic criteria. Students in all conditions then completed a survey assessing their prejudice toward people with BPD. There was no difference between conditions on overall prejudice toward people with BPD. However, the AMPD increased continuum beliefs and decreased categorical beliefs, and these, in turn, affected perceptions of people with BPD as ingroup members, which indirectly reduced prejudice. We have identified pathways through which the AMPD indirectly reduces prejudice toward people with BPD.
A Qualitative Exploration of Help-Seeking and Experiences of Diagnosis Among Men With Borderline Personality Disorder
Authors: Dean Chloe , Mildred Helen , Klas Anna , Rao Sathya , Broadbear Jillian H.
Published: October 2024

Borderline personality disorder (BPD) is frequently understood as a diagnosis applicable mainly to women, despite population studies suggesting similar prevalence between men and women. The scarce available information suggests that compared to women, men may face additional gender-related barriers to diagnosis and treatment when attempting to engage with support and treatment for BPD-related difficulties. The current study presents a qualitative in-depth exploration of the help-seeking and diagnosis experiences of four men with BPD. Using Interpretive Phenomenological Analysis, three themes were generated: (1) “There's just no help out there”: barriers to treatment; (2) self-understanding and insight; and (3) the importance of emotional and psychological connection with health care professionals and close family and friends. Having a greater understanding of male-specific experiences of BPD could improve the helpseeking journeys of men with BPD through early identification, accurate and timely diagnosis, to relevant and effective treatment and support.
Bilateral Alignment of Receptive Fields in the Olfactory Cortex
Authors: Grimaud Julien , Dorrell William , Jayakumar Siddharth , Pehlevan Cengiz , Murthy Venkatesh
Published: October 2024

Each olfactory cortical hemisphere receives ipsilateral odor information directly from the olfactory bulb and contralateral information indirectly from the other cortical hemisphere. Since neural projections to the olfactory cortex (OC) are disordered and nontopographic, spatial information cannot be used to align projections from the two sides like in the visual cortex. Therefore, how bilateral information is integrated in individual cortical neurons is unknown. We have found, in mice, that the odor responses of individual neurons to selective stimulation of each of the two nostrils are significantly correlated, such that odor identity decoding optimized with information arriving from one nostril transfers very well to the other side. Nevertheless, these aligned responses are asymmetric enough to allow decoding of stimulus laterality. Computational analysis shows that such matched odor tuning is incompatible with purely random connections but is explained readily by Hebbian plasticity structuring bilateral connectivity. Our data reveal that despite the distributed and fragmented sensory representation in the OC, odor information across the two hemispheres is highly coordinated.
Intercellular Adhesion Disorders In Tumorigenesis
Authors: Olga A. Bocharova , Regina V. Karpova , Evgeny V. Bocharov , Kucheryanu Valerian G. , Vyacheslav S. Kosorukov , Stilidi Ivan S.
Published: October 2024

The review discusses the problem of adhesion impairment in the course of tumorigenesis and aging. We hypothesize that impairment of homophilic intercellular adhesion in the target tissue results in developing conditions, which are favorable for malignancy, invasion, and metastases. Like a phoenix vanishing during the initiation of a primary tumor by breaking contacts between identical cells, adhesion molecules reappear with a new quality (the phoenix rising mechanism), thereby causing invasive and metastatic behavior of tumor cells. Due to this, primary tumor cells acquire motility and the ability to form metastases, which are the cause of most cancer deaths. At the same time, the provision of adhesive bonds between cancer cells and immune effector cells can also be controlled by one of the main neurotransmitters, dopamine (DA). The discovery of peripheral DA in lymphocytes gave grounds to the assumption that DA is involved in the infiltration of tumor leukocytes. DA receptors are found on cells of the adaptive (specific) immune response: T and B lymphocytes. Direct communication between brain DA and peripheral DA is crucial in modulating immune function. Peripheral DA mediates differentiation, binding to tumor cells, and cytotoxicity of CD8+ T cells. The review also confirms the need for the development of adhesion pharmaceutical agents. The disruption of intercellular adhesion in the target tissue and the general deficiency of immune surveillance can be controlled by central mechanisms involving brain DA, which is capable of regulating the active phase of immune responses against the tumor by means of adhesive interactions in the immune system, interfering with the process and thereby interrupting the development of a malignant neoplasm initiated by a local mutation in the tissue. The concept reveals the stress mechanism of cancer etiology and creates prospects for new methods of diagnostics, prevention and treatment of tumors, which can become another step towards solving the problem of malignant neoplasms.
Association Between Pharmacotherapy And Circulating Hematological Profile In Rheumatoid Arthritis
Authors: Talar A. Merza , Marwan S.M. Al-Nimer
Published: October 2024

Background — Hematological indices are useful predictors and prognostic biomarkers in rheumatoid arthritis (RA). Some antirheumatic drugs (ARD) have a negative effect on circulating blood cells and bone marrow and therefore may bias the interpretation of biomarker value. Objective — Our cross-sectional study aimed to demonstrate the effect of ADR use on peripheral blood indices in RA patients. Methods — This cross-sectional study was conducted on 103 adult RA patients and 21 healthy subjects at Rizgari Teaching Hospital in collaboration with the Department of Clinical Pharmacy and College of Pharmacy, Hawler Medical University, Erbil, Iraq, from January 2020 through December 2022. Patients were treated with methotrexate (MTX), hydroxychloroquine (HCQ), biologics (BL), MTX+HCQ, MTX+BL, and HCQ+BL. RA activity and complete blood count were obtained from patient records. Results — Our results implied that HCQ was associated with significantly lower hemoglobin levels, while MTX+BL was accompanied by significantly lower mean corpuscular volume. The mean platelet volume was significantly higher in all treatment groups than in healthy subjects. Conclusion — We concluded that BL use was statistically significantly associated with changes in hematological indices and ratios in patients with RA. It is important to consider the category of pharmacotherapy when interpreting circulating blood cell indices as predictors or prognostic biomarkers in RA.
Tumor necrosis factor inhibition may improve autonomic dysfunction in rheumatoid arthritis
Authors: Syngle Ashit , Verma Inderjeet , Krishan Pawan , Garg Nidhi
Published: October 2024

Autonomic nervous system (ANS) involvement in rheumatoid arthritis (RA) has been well recognized. Symptoms of autonomic dysfunction are absent and not specific, but diagnosis of ANS dysfunction by non-invasive means is warranted to prevent severe consequences. However, there is no study demonstrating therapeutic efficacy on autonomic neuropathy (AN) in RA. This is the first reported observation of improvement in AN with the TNF-α inhibitor (TNFi), infliximab in RA.
We report here a case of a 57-year-old, seropositive RA female with severe disease activity, investigated for AN. Non-invasive tests based on peripheral sympathetic and cardiovascular autonomic neuropathy (CAN) function were used for accurate assessment of autonomic function. The patient was treated with infliximab 3 mg/kg intravenous infusion at weeks 0, 2, and 6. An improvement in autonomic dysfunction was noted after 6 weeks of therapy in both sympathetic and parasympathetic CAN.
АНАЛИЗ СХОДИМОСТИ МНОГОШАГОВОГО МЕТОДА КОЛЛОКАЦИИ ДЛЯ РЕШЕНИЯ ОБОБЩЕННЫХ ИНТЕГРАЛЬНЫХ УРАВНЕНИЙ АВТОСВЕРТКИ ВОЛЬТЕРРА
Authors: ДАРАНИЯ П. , ПИШБИН С. , ЭБАДИ А.
Published: October 2024

В этом исследовании мы вводим многошаговые методы коллокации (МШМК) для решения интегральных уравнений Вольтерра (ИУВ) типа автосвертки, такие что без увеличения вычислительных затрат порядок сходимости предлагаемых одношаговых методов коллокации будет увеличен. Анализ сходимости МШМК исследуется с использованием теорем Пеано для интерполяции, и приводятся два численных примера для демонстрации значительного преимущества МШМК.

In this study, we introduce multi-step collocation methods (MSCM) for solving the Volterra integral equation (VIE) of the auto-convolution type such that without increasing the computational cost, the order of convergence of the proposed one-step collocation methods will be increased. A convergence analysis of the MSCM is investigated using the Peano theorems for interpolation and, finally, two numerical examples are introduced to clarify the significant advantage of the MSCM.
КЛАССЫ ПСЕВДОПЕРЕСТАНОВОЧНОСТИ КОМПЛЕКСНЫХ МАТРИЦ И ИХ ОВЕЩЕСТВЛЕНИЕ
Authors: ИКРАМОВ Х.Д.
Published: October 2024

Отношение между комплексными матрицами H и A, выражаемое равенством H A = ĀH , называется псевдоперестановочностью. Совокупность SH всех A, псевдоперестановочных с невырожденной n × n-матрицей H, называется классом псевдоперестановочности, определяемым этой матрицей. Всякий класс SH является подпространством пространства Mn(C), рассматриваемого как вещественное векторное пространство размерности 2n2. В предположении dimR SH = n2 найдено необходимое и достаточное условие для того, чтобы все матрицы из SH могли быть овеществлены одним и тем же подобием.

The relation between complex matrices H and A, given by the equality H A = ĀH is called the pseudo-commutation. The set SH of all A that pseudo-commute with a nonsingular n × n matrix H is called the pseudo-commutation class defined by H . Every class SH is a subspace of the space Mn(C) interpreted as a real vector space of dimension 2n2. Under the assumption dimR SH = n2, we find a necessary and sufficient condition for the possibility to decomplexify all the matrices in SH by one and the same similarity transformation.
ВЫЧИСЛЕНИЕ ФУНКЦИИ ПЛОТНОСТИ РАСПРЕДЕЛЕНИЯ ВЕРОЯТНОСТИ ФАЗ НА ОСНОВЕ РЕШЕНИЯ ОБРАТНОЙ ЗАДАЧИ
Authors: МАСЛАКОВ М.Л. , ЕГОРОВ В.В.
Published: October 2024

В работе рассматривается задача вычисления плотности распределения вероятности фазы сигнала с фазовой манипуляцией, принимаемого в условиях искажений и аддитивного шума. Данная задача сводится к решению обратной задачи, а именно интегральному уравнению типа свертки. В работе проанализированы функции, входящие в интегральное уравнение. Отдельно рассмотрен важный с практической точки зрения случай равновероятных фаз символов. Представлены результаты численного моделирования.

The article considers the problem of calculating the phase probability density function of a phase-shift keying signal received under conditions of distortion and additive noise. This problem is reduced to an inverse problem, namely, to solving an integral equation of the convolution type. The functions included in the integral equation are analyzed. The case of equiprobable symbols, which is important from a practical point of view, is considered separately. Numerical simulation results are presented.
АЛГОРИТМЫ СТОХАСТИЧЕСКОГО МОДЕЛИРОВАНИЯ ДЛЯ ИТЕРАЦИОННОГО РЕШЕНИЯ УРАВНЕНИЯ ЛАМЕ
Authors: АКСЮК И.А. , КИРЕЕВА А.Е. , САБЕЛЬФЕЛЬД К.К. , СМИРНОВ Д.Д.
Published: October 2024

В статье построены итерационные алгоритмы стохастического моделирования для решения системы уравнений Ламе, описывающей смещения изотропного упругого тела. Предложено три различных стохастических метода. Первый основан на глобальном алгоритме блуждания по сферам для вычисления решения и производных для анизотропного уравнения диффузии. Он является бессеточным и не требует большой оперативной памяти. Второй метод основан на рандомизированном алгоритме для решения больших систем линейных уравнений и требует введения сеток. Третий метод также является сеточным, он использует алгоритм случайного блуждания по сетке. Все три метода реализуют итерационный процесс, на каждом шаге которого решаются уравнения анизотропной диффузии. В работе проводится сравнительный анализ предложенных методов и обсуждаются границы применимости каждого из них.

In this paper, iterative stochastic simulation algorithms for the Lamè equation describing the displacements of an isotropic elastic body are constructed. Three different stochastic methods are proposed: the first one is based on a global algorithm of random walk on spheres to compute the solution and its derivatives for an anisotropic diffusion equation. It does not use grids and does not require large amounts of RAM. The second method is based on a randomized algorithm for solving large systems of linear equations and requires the introduction of a grid. The third method is also grid-based and uses a random walk algorithm. All three methods implement an iterative process, at each step of which anisotropic diffusion equations are solved. The paper provides a comparative analysis of the proposed methods and discusses the limits of applicability of each of them.
Evaluation of antioxidant activity and chemical profile of Cudrania tricuspidata tree pruning extract obtained by optimized microwave-assisted extraction
Authors: Ha Si Young , Jung Ji Young , Lee Jung Myoung , Yang Jae-Kyung
Published: October 2024

The residue from pruning Cudrania tricuspidata trees is considered a rich source of energy and bioactive compounds. Recovering these compounds from C. tricuspidata tree pruning could help mitigate potential economic and environmental concerns. The primary aim of this study was to investigate the impact of extraction temperature, duration, and liquid-to-residue ratio on the antioxidant activity, total phenolic content, and total flavonoid content of C. tricuspidata tree pruning, using the response surface methodology. The results indicated that the microwave-assisted extraction temperature or microwave-assisted extraction time was the most crucial variable in the extraction process (Significance at p-value < 0.001 – 0.05 for antioxidant activity and chemical profile). It is worth mentioning that the optimal extraction conditions for achieving maximum 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical cation induction activity, total polyphenol content, and total flavonoid content were distinct from one another, necessitating specific optimization for each targeted characteristic. The optimized extraction conditions yielded 85.8% DPPH radical scavenging activity, 95.4% ABTS radical cation induction activity, 2.72 mg/g total polyphenol content, and 2.53 mg/g total flavonoid content. These results highlight the potential of C. tricuspidata as a valuable dietary source of phenolic antioxidants for human health.
Chemical composition and biological activities of essential oils from Alyssoides utriculata (L.) Medik
Authors: Üçüncü Osman
Published: October 2024

The chemical compositions, antioxidant activities, and antimicrobial activities of the essential oils acquired from the separated parts of air-dried flowers, leaves, and stems of Alyssoides utriculata L. plant growing in Turkiye were determined. Three volatile oil components were acquired via hydrodistillation using a Clevenger apparatus and analyzed by the Gas Chromatography-Mass spectrometry/Flame Ionization Detection (GC-MS/FID) analysis. A total of 75, 67, and 76 compounds in the volatile oils of flower, leaves, and stem of A. utriculata were identified, respectively. The highest percentage of chemical compounds in the essential oils of A. utriculata were determined to be monoterpenes in flowers and leaves, (72.4% and 66.5%) and hydrocarbons (29.2%) in stems. While α-pinene (62.5% and 46.7%) was defined as the major compound in the flowers and leaves, nonane (21.2%) was determined to be so in the stem essential oil. The antioxidant activity of the obtained essential oils was determined according to free radical scavenging and total phenolic content (TPC), and antimicrobial activity against 12 bacteria and 5 fungi, using the agar dilution method. The amount of TPC and scavenging activity of the flower oil were found to be 440.61 ± 6.26 mg GAE/L and 46.00 ± 1.28%, respectively. Based on the antimicrobial activity results, all the essential oils of A. utriculata were determined to have antimicrobial activity against Escherichia coli and Bacillus subtilis.
Cáncer de mama en varón de presentación atípica
Authors: Yan-Quiroz Edgar F. , Agreda Castro Folker , Villarreal Gonzáles Mery Nancy , Tenazoa Villalobos José Richard , Ordoñez Chinguel Augusto Magno , Luna Córdova Cesia Jemima , Guzmán Aponte Aldaír
Published: October 2024

El cáncer de mama es una neoplasia poco frecuente en hombres y representa el 1% de todos los cánceres de mama. Su baja prevalencia y el limitado conocimiento de los médicos sobre esta enfermedad genera un diagnóstico en estadios avanzados. Presentamos el caso de un paciente varón de 44 años, con tumor en región esternal, de larga duración, cuya demora en el diagnóstico clínico e histopatológico favoreció la progresión de la enfermedad a nivel axilar derecho, retrasando su tratamiento. Recibió radioterapia y quimioterapia adyuvante, al igual que terapia con trastuzumab, con buena tolerabilidad.
Asociación entre la calidad de atención prenatal y el bajo peso al nacer en Perú
Authors: Tolentino-Izquierdo Andrea , Tong Diaz de la Vega Maria Alejandra , Romani-Romani Franco
Published: October 2024

Introducción. En Perú, poco estudios han evaluado adecuadamente si las atenciones prenatales en los establecimientos de salud protegen del bajo peso al nacer de los niños. Objetivo. Determinar la asociación entre la calidad de la atención prenatal y el bajo peso al nacer (BPN) en el Perú. Métodos. Estudio trasversal analítico de fuentes secundarias con datos de la Encuesta Demográfica y de Salud Familiar de Perú del 2021. La exposición fue la calidad de la atención prenatal determinada por tres dimensiones: número de controles, momento del primer control y cumplimiento de las intervenciones programadas. La calidad de la atención prenatal fue «adecuada» cuando los tres componentes fueron correctamente cumplidos. El BNP correspondió a menos de 2500 gramos. Resultados. Analizamos datos de 18 484 mujeres y sus respectivos hijos. Entre los nacidos a término el 2,9% tuvo BPN. El 85,9% tuvo de 6 a más controles prenatales. El 79,8% tuvo su primer control en el primer trimestre de la gestación. El 47,4% cumplió los nueve componentes de la atención prenatal. No hubo asociación entre la inadecuada calidad de atención prenatal y el BPN (OR = 1,14; IC95%: 0,86 a 1,52; p = 0,360). Mujeres con menos de 6 controles tuvieron 57% mayor odds de BPN comparados con recién nacidos cuyas madres tuvieron 6 o más controles (IC95%: 1,11 a 2,23; p = 0,012). Conclusiones. En las gestaciones a término, no encontramos asociación entre la calidad de atención prenatal y BPN. Gestantes con menos de 6 atenciones prenatales tuvieron mayor riesgo de un recién nacido con BPN.
Residentado médico en administración y gestión en salud en Perú: análisis de las vacantes ofertadas y planes curriculares
Authors: Arce-Huamani Miguel A. , Bendezu-Quispe Guido , Taype-Rondan Alvaro , Ramirez-Rodriguez Miluska , Robles-Guerrero Luis Ricardo , Cortegana-Aranda José Alberto
Published: October 2024

Introduction. The lack of research in Health Administration and Management (AyGS) training, along with the need to improve residency programs, motivated this study. Objective. We described the availability of offered positions and curriculum plans for AyGS residency programs in Peru. Methods. Descriptive observational study. We reviewed the number of positions offered and awarded between 2013 and 2022 on the National Medical Residency Council (CONAREME) website. Additionally, we analyzed curriculum plans updated to 2022, identifying minimum achievements per academic year and comparing them with CONAREME standards. Results. Between 2013 and 2022, nine universities offered the AyGS residency program, with six located in Lima. The allocation of open vacancies showed a higher trend, reaching 100% in four of the ten years analyzed, while the highest allocation percentage for captive positions was 78%. Regarding the curriculum plans, six of the eight available in 2022 provided information on minimum achievements and described the courses that residents must take. Conclusion. There were no changes in the total number of positions offered for the AyGS program. Three universities in Lima concentrate more than 50% of the program offerings. The curriculum plans show similarities across the universities offering the program.
Eritema en guante calcetín asociado a infección por COVID-19
Authors: Torres-Salinas Carlos
Published: October 2024

El eritema papulopurpúrico en guante calcetín es una entidad infrecuente y es causada principalmente por el parvovirus B19, en general suele tener un carácter benigno y se ha descrito en menor frecuencia otros causantes como la hepatitis B, citomegalovirus, Epstein-Barr, herpes y coxsackie. Sin embargo, su asociación post infección por Sars-CoV-2 en niños no ha sido descrita. Se presenta el caso de una niña de 7 años que muestra que esta asociación es posible, y debe ser planteada como una causa probable frente a este eritema.
Primera experiencia de criobiopsia transbronquial para enfermedad pulmonar intersticial difusa en un hospital nacional de Lima, Perú
Authors: Mendoza Jorge R. , Small-Mauro Max
Published: October 2024

Transbronchial cryobiopsy has been described as a new method to obtain lung tissue, demonstrating good correlation with surgical lung biopsies, fewer complications, costs and hospital stay. We describe our first experience carried out successfully in a national hospital. This is a 53-year-old female patient, with a disease duration of five years, characterized by progressive dyspnea. Non-UIP standard tomography. Rheumatological study: mixed positive ANA, speckled nuclear 1/2560 and nucleolar 1/5120. Anti-ENA positive, ANCA negative. Spirometry with FVC 1.83 (69%) and diffusion test 10.39 (67%). After the evaluation of the multidisciplinary committee, a lung biopsy was indicated. After clinical and functional evaluation, cryobiopsy was performed with the use of general anesthesia, prophylactic endobronchial blocker, fluoroscopic guidance and cryoprobe.
Características de los fallecidos por golpe de calor en Perú
Authors: Ccami-Bernal Fabricio , Intimayta-Escalante Claudio , Salvador-Oscco Edison
Published: October 2024

Sr. Editor,
Durante los últimos años, el impacto del cambio climático se ha hecho más evidente. En enero del 2024 se destacó como uno de los meses más calurosos registrados en Perú, marcado por temperaturas diurnas abrasadoras y máximas de hasta 39°C (1). En respuesta, el Ministerio de Salud ha emitido alertas epidemiológicas sobre golpe de calor (GC) (2). Sin embargo, la falta de estrategias efectivas para mitigar los riesgos de muertes relacionadas con el calor en Perú ha resultado en un aumento de los informes de muertes por GC (3). Por tanto, este estudio presenta una descripción de la población peruana fallecida por GC.
Calidad de los fenotipos humanos en pacientes con discapacidad intelectual con estudios de secuenciación de exoma en un hospital pediátrico peruano
Authors: Custodio-Sánchez Pedro , Abarca-Barriga Hugo
Published: October 2024

Introduction. Massive sequencing and the Human Phenotype Ontology have revolutionized genetic diagnosis, allowing for a clearer understanding of diseases. The phenotypes described in medical records can be specific or general, the more detailed and specific the description, the higher the quality of the information. Objectives. To determine the relationship between the quality of human phenotypes in patients with intellectual disability and the findings from massive sequencing test at the Instituto Nacional de Salud del Niño. Methods. We analyzed 124 patients with intellectual disabilities with exome sequencing. The quality of human phenotypes was evaluated using different quality index. Results. A total of 278 human phenotype terms were identified. Phenotypic precision improved after filtering, highlighting the importance of specific phenotypic descriptions (from 103 to 86 unique terms). The specificity index of the dataset was lower in the group with variants of uncertain significance compared to the group with pathogenic variants (0 vs. 0.05). The most frequent phenotypes were psychomotor delay (12.9% - 15.9%) and microcephaly (4.5% - 5.2%). Conclusions. The importance of evaluating the quality of human phenotypes is highlighted. The presence of uncertain variants suggests a genotype-phenotype complexity, emphasizing the need for greater clarity in genetic interpretation. Consistency in confidence intervals and the specificity index of the dataset underscores the competence of local medical-genetic personnel.
Impacto de la gestión de desempeño en una institución estatal peruana para mejorar la inversión pública en infraestructura educativa
Authors: Calopino Arellano César Jarzinhio , Astete Flor César
Published: October 2024

El objetivo de este artículo fue analizar el impacto de la gestión de desempeño en una institución estatal para mejorar la infraestructura educativa escolar durante el periodo 2015-2022. El Programa Nacional de Infraestructura Educativa (PRONIED) es la institución encargada de velar por la buena gestión de la inversión pública para la conservación, reposición y mejora de la infraestructura escolar en todo el Perú, por lo que su gestión debe ser revisada en base a los objetivos y resultados de indicadores de desempeño institucional en el tiempo que está en funcionamiento. El método que se empleó en la investigación fue de tipo aplicado, con diseño longitudinal y enfoque cuantitativo. Asimismo, la muestra que se empleó fue cuantitativa, elaborada por serie de datos, la que fue obtenida de los indicadores de desempeño extraídos de la página web del gobierno. Los resultados que se obtuvieron confirman la comprobación de las hipótesis, partiendo de la premisa que la gestión del desempeño institucional tiene un impacto sobre la inversión pública en infraestructura escolar. Es así como se afirma la existencia de veracidad estadística en nivel moderado (con R2 = 68%) vinculado con la linealidad o relación de los Procesos de Inversión Pública en infraestructura educativa (PIP) y la gestión de desempeño institucional de PRONIED (representada por actividades de mantenimiento preventivo y correctivo, e igualmente con los proyectos terminados). La conclusión general es que existe un impacto significativo de la inversión pública en infraestructura educativa sobre la gestión del desempeño del PRONIED.
La evolución de la gestión de la calidad y sus dimensiones: Seguridad y Capacidad de respuesta. Análisis teórico
Authors: Alvarez Caballero Yuliana Geraldine
Published: October 2024

Las organizaciones se han visto en la necesidad de responder a la alta competitividad del mercado, siendo la gestión de la calidad una de sus más grandes preocupaciones. El propósito de la pesquisa es realizar un análisis teórico con referencias actualizadas sobre la gestión de la calidad en las organizaciones, considerando que es relevante para los interesados tener un documento en el que puedan encontrar los diferentes postulados presentados por investigadores en distintas regiones del mundo. La investigación se realizó mediante una revisión bibliográfica en importantes repositorios de artículos científicos. Posteriormente, se procedió a sintetizar y a organizar la información de manera que resulte fácil de revisar y entender para los lectores. El objetivo general de este artículo es estudia la evolución del concepto de gestión de la calidad dentro de las organizaciones, teniendo como objetivos específicos analizar las dimensiones de Seguridad y Capacidad de respuesta. Como conclusión, se destaca que, a través del tiempo, la gestión de la calidad ha experimentado modificaciones significativas en su alcance dentro de la organización, ganando importancia. Actualmente, existen teorías, modelos y herramientas que ayudan a las empresas en la eficiente gestión de la calidad para lograr la satisfacción del cliente.
Assessment of sweet whey fortified with Bifidobacteria and selenium on reduction of pesticide liver toxicity in albino rats
Authors: M.S. Moawad Raghda , H.A. Osman Ali , M.A. Hassanein Khaled , F. Elkot Wael , Mahmoud Asar Ahmed , Alhag Sadeq K. , Al-Shuraym Laila A. , Alghamdi Othman A. , AL-Farga Ammar , T. Zaidalkilani Ayah , M. Hassan Hanaa
Published: October 2024

Deltamethrin (DLM) represents one of the most commonly used pesticides. It passes through milk, vegetables, and fruits to humans or through animals (veterinary drugs and feeding on contaminated forage) to milk; it can escape from skin to blood and be secreted in breast milk in lactating women. It is believed to have neurotoxic, nephrotoxic, and hepatotoxic properties. To investigate deltamethrin-induced hepatotoxicity, 64 rats were divided into eight groups. The control group did not receive any treatment. The groups were as follows: D 30 mg DLM/kg body weight (BW) dissolved in corn oil; B 1 mL whey (1010 cfu/mL of Bifidobacterium longum ATCC 15707); S 1 mL whey (0.5 ppm selenium); BS 1 mL whey (1010 cfu/mL of B. longum ATCC 15707 + 0.5 ppm selenium); BD 1 mL whey (1010 cfu/mL of B. longum ATCC 15707 + DLM); SD 1 mL whey (0.5 ppm selenium) + DLM; and BSD 1 mL whey (1010 cfu/mL of B. longum ATCC 15707) + 0.5 ppm selenium + DLM. Results revealed that the manipulation of Bifidobacteria with selenium triggered a significant improvement in AST (U/mL), ALT (U/mL), GSH (mg/g), TNF-α (pg/mL), NF-κB (ng/mL), and BCL2 (ng/mL) from 166.7 ± 6.42, 30.67 ± 0.55, 0.252 ± 0.005, 17.18 ± 0.42, 1.14 ± 0.10, and 1.77 ± 0.06 versus 334.9 ± 4.7, 72.83 ± 2.49, 0.108 ± 0.005, 33.57 ± 0.59, 2.58 ± 0.05, and 1.04 ± 0.04, respectively, compared to DLM group. As well as reduction in histopathological necrosis, congestion, and degradation. Whey beverages fortified with B. longum and selenium implicated a reduction in oxidative stress and histopathological degradation that accomplished DLM toxicity. The utilization of whey (a byproduct of cheese making) is considered a recycling process that supports eco-friendly practices and sustainability, thus encouraging its use as a protective tool in animal feed or manipulation by humans, especially workers in pesticide plants.
Exploring Quadrilaterals: An Interactive Task for 7th Grade Students Using GeoGebra Classroom
Authors: Santos Vanda , Teles Joana , Quaresma Pedro
Published: October 2024

Using a Dynamic Geometry System (DGS) students can engage in a dynamic learning process that allows them to experiment, create strategies, make conjectures, argue, and deduce mathematical properties. A DGS enables the introduction of proofs, by providing visual aids. The proof of
the conjectures made emerges as the next step towards formalising and understanding the contents covered and the introduction of automated deduction systems at schools can be an added value. The implementation of automated deduction systems in schools faces several challenges, such as curriculum-issues,
teacher knowledge and the discrepancy between automated theorem provers and traditional practices of proving in schools. Synthetic provers based on a set of inference rules and forward chaining reasoning may provide a possible help to these challenges. With the aim of introducing formal proofs
and inspiring students towards this goal, a geometric conjecture was chosen for 7th grade students to engage with, based on a rule set discussed in a previous work, “A rule based theorem prover: an introduction to proofs in secondary schools”. The study also aimed to showcase the
application of a Geometry Automated Theorem Prover within the classroom setting. A sequence of tasks was created for students to complete using GeoGebra Classroom. In the first phase, they were asked to identify quadrilaterals, construct a parallelogram, and measure sides and angles until
they formulated a conjecture, which was strengthened by the dynamic possibility of changing the constructed parallelogram. In the second phase, the students were provided with four rules and were asked to justify their results using these rules. By the end of these justifications, the students
had a complete proof of the initial conjecture. A short video of the proof made using JGEx (Java Geometry Expert) was also shown to the students.
Automated Feedback on Student Attempts to Produce a Set of Dimensionless Power Products from a Set of Physical Quantities that Describe a Physical Problem
Authors: Lundengård Karl , Johnson Peter , Ramsden Phil
Published: October 2024

Formative feedback is important in learning. Automating the provision of specific, objective, constructive feedback to large cohorts requires complex algorithms that most teachers do not have time to develop, suggesting that a community effort is needed to create a library of
specialised algorithms. We present an exemplar algorithm for a class of tasks in ‘dimensional analysis’ relating to the Buckingham Pi theorem. The challenge arises because there are infinitely many valid and invalid answers, but any valid answer is sufficient to complete a task.
We present an algorithm that, given one valid reference answer, can evaluate any response to a task. The algorithm uses a vector-space formulation of the Pi theorem. Deployment across seven tasks for 380 students provided feedback 3,090 times, including stating why a response is invalid. The
most common reason was that a student-proposed set was not dimensionless, but other educationally relevant reasons were also identified.
Using Digital Game-Based Learning in Mathematics Education: A Case Study with Teacher Training Students
Authors: Debrenti Edith
Published: October 2024

Using game-based learning (GBL) and digital game-based learning (DGBL) as a teaching and learning environment can be a pedagogical resource and a good strategy in the classroom to support mathematical learning (Santos et al.,2023). Even though primary school teachers are demonstrating
strong preferences for using non-digital games instead of digital games to support mathematics instruction, much of the research review literature has focused on learning outcomes associated with digital mathematical games (Russo et al., 2024). In this paper, I conduct a quasi-experiment using
an empirical action research method and the same logical problem-solving environment–game-based or digital game-based learning–that I designed and used with two groups of pre-service teacher university students. I tested three digital games with their non-digital equivalent and
observed the problem solvers primarily from a qualitative point of view. Most of the participants enjoyed working with both physical cards and digital games, which effectively engaged students in solving the tasks. My findings suggest that students found the task-solving enjoyable in both
types of game-based learning and that solving tasks non-digitally with cards could be more flexible for the problem solvers.
Simulating the Local Universe
Authors:   P. N. Lebedev Physical Institute, Russian Academy of Sciences, Pilipenko S. V.
Published: October 2024

The Local Universe is defined as the region within a radius of about 100 Mpc around our Galaxy. Being the most extensively studied region, it is of great interest to cosmologists. Research on the Local Universe allows us to answer questions about our understanding of the structure of the Universe, whether we can explain the observed variety of o©ects within it, and how typical our closest environment is. This lecture discusses one of the ways to address these questions: numerical modeling of the Local Universe.
Interstellar extinction and polarization towards the globule CB54
Authors:   Saint Petersburg State University, Kobozeva V. A.
Published: October 2024

BVR photometry of several hundred stars in a 10 X 15' field around the CB54 globule was performed. The results are supplemented with Gaia DR3 parallaxes as well as data from the photometric sky surveys. The X2 approach is used to classify the stars observed and to estimate the visual extinction for them. The relationship between interstellar extinction and polarization is analyzed, using available polarimetry of approximately 50 stars. The results obtained allow one to make conclusions on the material distribution and magnetic field orientation in the Galaxy region under consideration.
The Yarkovsky effect in the dynamics of asteroid (99942) Apophis during its approach to the Earth in 2029
Authors:   The Central Astronomical Observatory of the RAS at Pulkovo, 2Saint Petersburg State University, Lobanova K. S. , Melnikov A. V. ,   The Central Astronomical Observatory of the RAS at Pulkovo, 2Saint Petersburg State University
Published: October 2024

By means of numerical modelling, the changes in the rotational state of asteroid (99942) Apophis during its approach to the Earth in 2029 are studied. The influence of these disturbances on the magnitude of the Yarkovsky effect acting in the orbital dynamics of the asteroid is considered. It is established that, after approach, the average rate of change in the semi-major axis of Apophis orbit, caused by the Yarkovsky effect, can range from -235 to -20 m/yr.
Catalog of proper motions of extragalactic radiosources
Authors:   Saint Petersburg State University, Osetrova A. A. , Titov O. A. ,   Geoscience Australia
Published: October 2024

Extragalactic radio sources exhibit apparent proper motion, which is mainly caused by changes in the structure of objects on a long time interval. The proper motions induced by the structure of objects can be expected to be 1 mas/year. In addition to individual proper motions, there may be systematic ehects with amplitudes less than 0.01 mas/year may also be present in the proper motions. The search for such ehects requires the compilation of a catalog of radio source proper motions, from which objects whose apparent proper motion is obviously caused by changes in the radio source structure will be excluded. The paper describes the procedure for compiling such a catalog of apparent proper motions of extragalactic radio sources observed in 1993-2023.
Mass distribution of young spectroscopic binary stars
Authors:   Chelyabinsk State University, Tarasova D. V.
Published: October 2024

The mass distribution of the components is constructed and approximated by the power- law dN " M-rd lg M using the observation data about 57 pre-main sequence doubl^lined spectroscopic binaries. For stars with mass 1.0Mq г = 1.49±0.47, this is close to the Salpeter mass function. In the mass range 0.1M© г = -(0.92 ± 0.87). In general, the mass distribution of young stars may be approximated with the lognormal law, which the most probable mass Mprob = (0.82 ± 0.05)Mq
Changes in the blue wing profile of the Hα line in the spectra of the young variable star V645 CYG
Authors:   Kourovka observatory of the Ural Federal University, Gorda S. Yu. , Bisyarina A. P. ,   Kourovka observatory of the Ural Federal University, Sobolev A. M. ,   Kourovka observatory of the Ural Federal University
Published: October 2024

The results of a 7-year (2017-2023) spectral study of the young variable star V645 Cyg, which is a Herbig Ae/Be object and located in a region of active star formation, are presented. The spectral region in the Ha line was studied. Along with the previously discovered significant increase in the brightness and reddening of the color of V645 Cyg, the increase in the absorption component of the blue wing of the Ha line profile is interpreted within the framework of the assumption of a decrease in the optical thickness of the expanding gas-dust cocoon and an increase in the visibility of regions of the gas-dust envelope heated by the star’s radiation.
Optimization of observational strategy in measurement of radial velocities using the cross-correlation method
Authors:   Special Astrophysical Observatory RAS, Zhuklevich G. S. , Panchuk V. E. ,   Special Astrophysical Observatory RAS
Published: October 2024

The paper presents the results of using a cross-correlation algorithm to establish the Doppler velocity of a synthetic spectrum under various conditions. The purpose of the study was to establish a set of parameters at which finding the required radial velocity seems possible. The simulation covered spectral resolution, interpolation methods, cross-correlation intervals, and signal-to-noise ratio. Key results point to the importance of increasing spectral resolution.
Study of methanol emission at frequencies 216—234 GHz in the high mass protostellar object G12.89+0.49 (IRAS18089—1732)
Authors:   Ural Federal University, Salii S. V. , Sobolev A. M. ,   Ural Federal University, Ladeischikov D. A. ,   Ural Federal University, Yu H. Z. ,   Ural Federal University, Liu Sh.-Y. ,   Institute of Astronomy and Astrophysics, Academia Sinica, Taiwan
Published: October 2024

Preliminary results of work on the study of the massive protostellar object G12.89+0.49 are presented based on observations made with the ALMA interferometer in the frequency range 216-234 GHz. In the resulting spectra, averaged over an area of 1.6", more than 30 methanol lines were identified, corresponding to transitions with significantly diherent excitation conditions. Temperature estimates range from 60 to 350 K, number density from 104·5 to 10® cm-3, methanol column densities from " 1017 to " 1013 cm-2. The estimates are consistent with those of other authors, but are not unambiguous thus a more detailed analysis of the physical conditions in the facility is necessary.
Dust and gas of NGC 628 galaxy
Authors:   Ural Federal University, Smirnova K. I. , Wiebe D. S. ,   Institute of Astronomy RAS
Published: October 2024

In this work we compare the radiation fluxes of dust and gas in star formation regions (SFR) of galaxy NGC 628. We use the latest data obtained on the JWST telescopes (7.7 and 21 ^m), VLT (optical spectroscopy), and ALMA (CO 2-1 line) with data obtained on Spitzer (8 and 24 pm) and IRAM (CO 2-1 line) telescopes.
EFFECT OF OUTBURSTS ON THE PRESENCE OF PEBBLES IN FEOSAD MODEL
Authors:   Institute of Astronomy, RAS, Topchieva A. P. , Molyarova T. S. ,   Institute of Astronomy, RAS,   Southern Federal University, Rostov-on-Don
Published: October 2024

The luminosity outbursts of young stellar objects affect the physical structure and dust properties of the surrounding protoplanetary disks. We present the results of the two-dimensional hydrodynamic code FEOSAD, which simulates the global evolution of a self-gravitating viscous protoplanetary disk, taking into account thermal balance and dust coagulation and fragmentation. The model includes the dynamics of the main volatiles (H2O, CO2, CH4, and CO) in the gas, on small dust, on grown dust, and on pebbles. We consider the effect of outbursts on the presence of pebbles in the protoplanetary disk, as well as on the composition of their ice mantles. We show that pebbles are efficiently destroyed during luminosity outbursts.
Variations in the relative abundance of hemipteran species in different seasons and stages of rice growth depending on weather variations
Authors: Khalıd Faıruz , Shaıkh Mazran Noor Shuhaına , Rakıbe Ismaıl , Mohammed Muhamad Azmı , Aman Zuki Ameyra , Yaakop Salmah
Published: October 2024

Rompin has played an active role in Malaysia's rice production for several decades. However, it also faces a threat, particularly from the hemipteran insect pests. There is limited documentation on the abundance of these insects and their relationship with climatic factors. Therefore, this study aimed to determine the abundance of hemipterans in different growth stages and to understand the effects of climatic factors on their population in rice fields. The study was conducted in farmers' rice fields in Rompin, Pahang, Malaysia, during the main and off-season rice planting. Sweep nets, yellow sticky traps, and yellow pan traps were utilized in each plot. Trapped insects were identified based on the rice planting seasons and growth stages. The trends of climatic factors such as rainfall, temperature, light intensity, and wind speed were analysed and correlated with insect abundance. A total of 23,023 individuals belonging to eight families and eleven species of the hemipteran order were recorded. Nine of these species were pests, namely Leptocorisa oratorius, Recilia dorsalis, Nephotettix virescens, N. nigropictus, Amaurochrous dubius, Nilaparvata lugens, Sogatella furcifera, Nezara viridula, and Scotinophara coarctata. The remaining two species were predators, Cyrtorhinus lividipennis and Polytoxus fuscoviftatus. R. dorsalis, N. lugens, S. furcifera, and A. dubius were found in significantly higher numbers and exceptionally high during rice's late vegetative and early reproductive stages. The maximum temperature significantly increased during the main season, while wind speed increased dramatically during the off-season. Wind speed significantly correlated with N. virescens, S. furcifera, L. oratorius, and A. dubius. On the other hand, rainfall exhibited a significant correlation with L. oratorius. Various pest species and their high populations in this study pose a significant threat to plants due to their preferences for different plant parts and strata.