bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficacy of Lipid-Lowering Therapy During Cardiac Rehabilitation in Patients With Diabetes Mellitus and Coronary Heart Disease
Authors: Wittlinger Thomas , Schwaab Bernhard , Voeller Heinz , Bongarth Christa , Heinze Viktoria , Eckrich Kristina , Guha Manja , Richter Michael , Schlitt Axel
Published: May 2021

BackgroundCardiac rehabilitation (CR) in patients with coronary heart disease (CHD) aims to increase adherence to a healthy lifestyle and to secondary preventive medication. CR is able to improve quality of life and prognosis in CHD patients. This is particularly relevant for CHD patients with diabetes mellitus.DesignA prospective, multicenter registry study with patients from six rehabilitation centers in Germany.MethodsDuring CR, 1100 patients with a minimum age of 18 years and CHD documented by coronary angiography were included in a LLT registry.ResultsIn 369 patients (33.9 %), diabetes mellitus was diagnosed. Diabetic patients were older (65.5 ± 9.0 vs. 62.2 ± 10.9 years, p < 0.001) than nondiabetic patients and more likely to be obese (BMI: 30.2 ± 5.2 kg/m2 vs. 27.8 ± 4.2 kg/m2, p < 0.001). Analysis indicated that diabetic patients were more likely to show LDL cholesterol levels below 55 mg/dL than patients without diabetes at the start of CR (Odds Ratio (OR) 1.9; 95 % CI 1.3 to 2.9) until 3 months of follow-up (OR 1.9; 95 % CI 1.2 to 2.9). During 12 months of follow-up, overall and LDL cholesterol levels decreased within the first 3 months and remained at the lower level thereafter (p < 0.001), irrespective of prevalent diabetes. At the end of the follow-up, LDL cholesterol did not differ significantly between patients with or without diabetes mellitus (p = 0.413).ConclusionWithin 3 months after CR, total and LDL cholesterol were significantly reduced, irrespective of prevalent diabetes mellitus. In addition, CHD patients with diabetes responded faster to LTT than nondiabetic patients, suggesting that diabetic patients benefit more from LLT treatment during CR.
Pseudotachylyte Veins in Accretionary Complexes: Melt or Mechanical Wear?
Authors: Moris-Muttoni Benjamin , Raimbourg Hugues , Augier Romain , Champallier Remi , Trong Emmanuel Le
Published: May 2021

Whether seismic rupture propagates over large distances to generate mega-earthquakes or is rapidly arrested mainly depends on the slip processing within the fault core, including in particular frictional melting or intense grain-size reduction and amorphization. The record of seismic slip in exhumed fault zones consists in many instances in Black Faults Rocks, dark and glass-like-filled aphanitic veins that have been interpreted as resulting from quenching of frictional melts, i.e., pseudotachylytes. Such interpretation has nevertheless been questioned as similar macro to nano-textures have been observed either on intensely comminuted natural fault rocks or on slow creep experiments on crustal rocks, where melting is absent. Here, we report a new dataset of Raman Spectroscopy of Carbonaceous Material analyses, aimed at discriminating the slip weakening processes operating in the fault core during slip. Using high spatial resolution profiles on natural Black Fault Rocks from accretionary complexes and an experimentally calibrated modelling of Raman intensity ratio evolution with temperature, we assessed different scenarios of temperature evolution during fault slip. In the three studied Black Fault Rocks interpreted so far as natural pseudotachylytes, Raman Spectroscopy of Carbonaceous Material results are not consistent with a molten origin and therefore should reflect a mechanical wear during deformation. These results bear major consequences on the dynamics of faulting, as the slip-weakening processes that occur during seismic slip rely on the extreme grain-size reduction and fluidization rather than melting.
The development trends and features of online news websites in Bangladesh
Authors: Kabil Khan Abdul , Shnaider Anna
Published: May 2021

This article refers to the brief history of the development of online media in Bangladesh starting from the beginnings of the Internet to the contemporary stage.

Since 2006 Bangladeshi news organizations have been reshaping their strategy towards being a digital-only news outlet. News organizations are now using different features of mobile devices and social media to tell stories and engage with their target audiences. Today both the digital-only news outlets and mainstream media use QR codes, messengers, social media platforms, which enable them to reach a wider area of audiences. By using yet inexpensive digital tools journalists can easily create and distribute content for digital-only platforms.

We consider digital-only platforms as new media, social media, and convergence media platforms. Social media platforms have provided the opportunity for traditional journalists to share news quickly, get feedback from the audience, and have two-way communication with the reader.

Previous studies have looked at the genres of online journalism from a western perspective. Little has been done on the topic from the context of Bangladesh.

In this article, we analyze the basic features of online news media that exist in contemporary Bangladesh and provide an account of the development trends. We outline the new genres, techniques, and use as a sample two most famous online news platforms: The Daily Star and bdnews24. A series of semi-structured interviews were conducted with 5 different professionals from Journalism and mass media. This study is based on both primary and secondary sources of qualitative data to understand the new genres of online news media, challenges, and opportunities to work in the ever-changing media landscape.
Analysis of changes in the administrative-territorial status of monoprofile cities of Donbas (late 1940s – 1980s)
Authors: Bohunenko Valeriy
Published: May 2021

Transformations of the administrative-territorial status of monoprofile cities of Donbas in the context of development of structural-settlement structure of the region in the late 1940s and 1980s are considered. The urgency of the study is due to the reform of decentralization in Ukraine – changes in the order of local self-government and territorial organization of power. Its goal is to create communities that are self‑sufficient and effective in the economic, administrative and socio‑cultural dimensions. In the course of reform, monoprofile cities often acquire the status of centers of united territorial communities. In assessing the relevance of such decisions to the purpose of the reform, it is advisable to examine the relationship of structural-settlement, socio-economic and administrative-territorial status of these cities in historical retrospect. It turns out that the monoprofile cities of the region are an industrial-urban phenomenon, the genesis of which influenced the formation of the specifics of the settlement structure of Donbas. During the study period, the number of such cities more than doubled, reaching more than sixty cities in the late 1980s. Their share among the settlements of the region with the administrative status of a city was at that time two thirds. The emergence of monoprofile cities in the region in large numbers in the 1940s – 1980s is associated with government-industrial policy. At the same time, the structural and settlement importance of these settlements was reflected in their acquisition of the administrative-territorial status of region or district cities. From the beginning of the study period, the vast majority of cities with a narrow industrial base in the region belonged to the cities of district subordination, as they did not meet high enough urban criteria. In the urbanized region, in the presence of other, more powerful urban centers, the corresponding role in the administrative-territorial organization programmed the secondary nature of their structural settlement development. In particular, it did not contribute to the formation of micro-regions around these cities, which must be taken into account in the current conditions of reforming local self-government and territorial organization in the country.
EDTA/glycine-acid versus chloroquine diphosphate treatment for stripping Bg antigens from red blood cells
Authors: Champagne K. , Spruell P. , Chen J. , Voll L. , Schlanser G.
Published: May 2021

EDTA/glycine-acid (EGA) has been reported to remove IgG-bound antibodies from red blood cells (RBCs) and to denature Kell system and Era antigens. EGA-treated RBCs were tested in parallel with chloroquine diphosphate (CDP)-treated RBCs to evaluate whether EGA would remove Bg antigens from RBCs as efficiently as CDP. Fifty-seven serum/plasma samples containing known Bg antibodies were tested with untreated Bg+ RBCs, EGA-treated Bg+ RBCs, and CDP-treated Bg+ RBCs by an indirect antiglobulin test (IAT), using a low-ionic-strength additive solution and murine monoclonal polyspecific antiglobulin reagent. Of 57 samples, 40 (22 anti-Bga, 17 anti-Bgb, and 1 Bg-related) were nonreactive by IAT with EGA-treated RBCs and CDP-treated RBCs, 14 (7 anti-Bga, 4 anti-Bgb, and 3 Bg-related) were nonreactive by IAT only with EGA-treated RBCs, none were nonreactive in IAT with only CDP-treated RBCs, and 3 (anti-Bga) were still reactive by IAT with EGA-treated RBCs and CDP-treated RBCs. Therefore, EGA strips Bg antigens from RBCs. Our results indicate EGA treatment is more efficient and requires less time (1–2 minutes) to perform than the CDP procedure (30–120 minutes) for removal of Bg antigens from RBCs.
Immunohematology 1999;15:66–68.
Mta: review and case report
Authors: Bakowski L. , Kosanke J.
Published: May 2021

Anti-Mta, which recognizes an antigen in the MNS blood group system, was detected during prenatal testing of a para 6, gravida 1 woman with no history of transfusions. Her husband was apparently Mt(a–). Anti-Mta was first reported in 1962 as a naturally occurring antibody directed against a new antigen in the MNS system. The last report in the literature of detection of anti-Mta was in 1972.
Immunohematology 15;2:78–79.
Anti-Lu9: the finding of the second example after 25 years
Authors: Champagne Kayla D. , Moulds Marilyn , Schmidt Jo
Published: May 2021

The first and only reported example of antí-Lu9 (an antibody directed at a low-incidence antigen in the Lutheran blood group system and allelic to the high-incidence antigen Lu6) was described in 1973 in the serum of a white female, Mrs. Mull. Her serum also contained anti-Lul (-Lua), and subsequently, an anti-HLA-B7 (-Bga) was identified. We report the second example of anti-Lu9 in a white male (GR), found 25 years later. The GR serum was reactive in the indirect anti globulin test with Lu:-1,2,6,9 antibody-screening red blood cells (RBCs) using either a low-ionic-saline additive solution or polyethylene glycol for enhancement. Lu:6,9 RBCs were reactive with the serum when ficin- or EDTA/glycine-acid-treated, but nonreactive when trypsin- or α-chymotrypsin-treated. Six known examples of Lu; 9 RBCs were reactive with the GR serum. His serum did not contain anti-Lua, anti-HIA-B7 (-Bga) or antibodies to 34 low-incidence antigens tested. We have identified the second example of anti-Lu9 that was likely stimulated by transfusion. Because only one of 200 donors was found to be Lu:9, our study suggests that the incidence of the Lu9 antigen may be less than originally thought.
The Diego blood group system-an update
Authors: Gustavsson M.L , Oriol R. , Samuelsson B.E , Henry S.M
Published: May 2021

We orally administered to rats several times more Leb glycolipids than is proportionally found in the gastrointestinal tract of humans. This was done in an effort to study two potential phenomena: the possibility that glycolipids in plasma may originate from glycolipids derived from the lumen of the gastrointestinal tract and to investigate the potential to secondarily modify in vivo the glycolipid profile of gastrointestinal tract epithelial cells, a phenomenon clearly established for human erythrocytes, leukocytes, and platelets. We were able to establish that some of the orally administered glycolipids can be detected at the surface of the upper region mucosa of the gastrointestinal tract for more than 24 hours and are essentially excreted intact in stools in less than 72 hours. Some fecal degradation of the Leb glycolipids into Lea and H type 1 did occur. Although we clearly established that the glycolipids were present in the mucus layer adherent to the cell surface, we could not conclusively establish if the glycolipids had inserted into the epithelial cell membrane. This, however, could not be excluded. The fact that the fed glycolipids remained in the mucus layer of the upper region of the gastrointestinal tract tor at least 24 hours may have some pharmacological value. Using sensitive techniques, including red cell serology, immunohistology, and immunochemistry of glycolipids isolated from plasma and red cells, there was no evidence that the fed Leb glycolipids reached the plasma compartment, thus suggesting that glycolipids present in the lumen of the gastrointestinal tract cannot reach the circulation.
Immunohematalogy
1999;150.150-158.
The Diego blood group system-an update
Authors: Rumseuy D.H , Nance S.J , Rubino M. , Sandler S.G
Published: May 2021

Anti-Jka was detected by solid-phase red cell adherence(SPRCA) anti-body detection and identification tests in the plasma of a 9-month-old female intant during a roatine presurgical evaluation. the pation and her nonidentical twin sister who also had anti-Jka in her plasma, were products at an uncomplicated in vitro fertilization, full -term preganancy, and vaginal delivery Neither twin had been tranfered recently infected. or treated with medication. their mother had no prior pregnancies or transfusions. Red blood cells (RBCs) from the patient and her sister typed as Jk(a-b+) by direct hemagghutination and this phenotype was confirmed by negative adsorption and elution studies. Both infants plasma samples were strongly reactive with 20 examples of Jk(a+) RBCs and nonreactive with 20 examples of Jk(a-) RBCs by SPRCA assays. Anti-Jka was not detected in either twins plasma by Indirect antiglobulin tests by tube method in lowionie-strength saline solution or polyethylene glycol, or with ficin- or papain-treated RBCs. Monocyte monolayer assays using Jk(a+) RBCs sensitized by either twins’ serum were nonreactive (0%). RBCs from both parents typed as Jk(a+b+). Both parents’ antibody detection test results by SPRCA assay were negative. The absence of a history of exposure to allogeneic RBCs or possible passive transfer of maternal or other alloantibody classifies these antibodies as natually-occurring anti-Jka.
Immunohemalology
1999;15: 159-162.
Evaluation and comparison of three human monoclonal anti-S, two human polyclonal anti-S, and one murine anti-GPB
Authors: Halverson G.R , Reid M.E , Sutberland J. , Rhodes M.
Published: May 2021

Polyclonal anti-S react with Met28 or red blood cell (RBC) bound gly cophorin B (GPB) but may also require adjacent amino acids. Treatment of RBCs with certain enzymes and sodium hypochlorite based bleach (NaClO) affect the interaction of GPB with anti-S. Some, but not all, anti-S react with hybrid glycopborin molecules associated with the TSEN antigen. The purpose of this study was to characterize monoclonal anti-S and to compare their reactivity to polyclonal anti-S in order to determine their potential as blood group reagents and research tools. Furthermore, through inhibition experiments, we attempted to define the epitope recognized by the antibodies. Three monoclonal (MS-93: MS-94; MS-95) and two polyclonal (Al958; X1960) anti-S anti a monoclonal anti-GPB (Mab 148) were tested by standard hemagglutination with RBCs of known common and rare phenotype, with S+ RBCs treated with enzymes, with different concentrations of NaClO, and after incubation with synthetic peptides. The anti-S gave different patterns of reactivity. Reactivity with sialidase-treated RBCs showed that MS-93, MS-95. Mab 148. and X1960 recognize sialic acid independent epitopes, whereas MS-94 and A1958 require sialic acid for optimal reactivity. MS-95 and X1960 were strongly reactive with TSEN+ RBCs and only Mab 148 agglutinated S- Dantu+ and S- St(a+) RBCs MS-94 and Mab 148 agglutinated S+ RBCs treated with NaClO. MS-93 was inhibited only by the 14-mer S-specific synthetic peptide whereas MS-95 was inhibited by all three synthetic peptides containing S-relevant residues. This study clearly demonstrates that different anti-S have different characteristics that should be analyzed before selecting monoclonal antibodies for the basis of reagents for use in the clinical laboratory. These anti-S, because of their varied characteristics, will be useful research tools. Immunohematology 1999; 15:163-166.
Paroxysmal cold hemoglobinuria and the elusive Donath- Landsteiner antibody
Authors: Sokol R.J. , Booker D.J. , Stamps R.
Published: May 2021

Four patients with paroxysmal cold hemoglobinuria (PCH) illustrate some of the difficulties in making the diagnosis. A 46-year-old male presented with anemia, a weakly positive direct antiglobulin test (DAT) with anti-IgG, a haptoglobin < 0.1 g/L, and a cold autoagglutinin showing anti-P specificity. A 9-year-old female had a 4-day coryzal illness, a 20 g/L fall in hemoglobin over 24 hours, and a haptoglobin < 0.1 g/L; the DAT was positive with anti-C3d. A 3-year-old female was referred following a rapid drop in hemoglobin of 30 g/L; the DAT was positive with anti-C3d. A 17-month-old female, unwell for 2 weeks, had a hemoglobin of 41 g/L; the DAT was strongly positive with anti-C3d and weakly positive with anti-IgG and -C3c. In all patients, PCH was confirmed by positive indirect Donath- Landsteiner tests, and the autoantibodies demonstrated P specificity. In two patients, the test was strongly positive; in the third patient, it was only positive using papainized red cells; and in the fourth patient, a two-stage papainized procedure was needed before a positive result was obtained. PCH must always be considered in a child with a rapid drop in hemoglobin, even if initial tests are negative.
Antibodies to low-incidence antigens and elimination of the antihuman globulin phase of the crossmatch—case report: anti-Wra
Authors: Wise S.C. , Larson P.J. , Cook L.O.
Published: May 2021

An antibody to a low-incidence antigen was identified in the serum of a nontransfused male patient. The antibody was subsequently identified as anti-Wra and was only detectable at the antihuman globulin (AHG) phase of the crossmatch. Instances of severe hemolytic transfusion reactions have been reported following the transfusion of red blood cells containing low-incidence antigens in patients with antibodies directed toward these antigens (e.g., anti- Wra, -Cob, -Jsa, etc.). Elimination of the AHG phase of the crossmatch can result in either risks or benefits. Since patients seen at this facility primarily have been multitransfused or are multiparous females, the AHG phase of the crossmatch has been maintained.
Immunohematology
1997;13:20–22.
A clinically significant anti-HLA-A2 detectable by extended incubation cytotoxicity and flow cytometric techniques but not by a standard NIH lymphocytotoxicity test
Authors: Garner S.F. , Petrochilos J. , Brown C.J. , Cavanna S. , Chanarin I. , Navarrete C.
Published: May 2021

A previously transfused female patient, known to have a platelet defect, was transfused with platelets prior to surgery. After the 18th unit she felt unwell, developed fever, rigor, became nauseous, and vomited. Her blood pressure decreased from 140/90 to 80/50mm Hg. Passive transfer of donor granulocytes or red cell antibodies were excluded as a cause. Therefore, a serum sample from the patient was investigated for the presence of antibodies to human leukocyte antigens (HLA) using a standard National Institutes of Health (NIH) lymphocytotoxicity test, but antibodies were not detected. However, an extended incubation cytotoxicity test demonstrated the presence of an anti-HLA-A2, and indirect immunofluorescence flow cytometry showed the presence of an IgG1 antibody reacting with 50 percent of cells in a random pool of lymphocytes. One week later, multispecific HLA antibodies were detectable by both NIH and extended incubation cytotoxicity tests. Flow cytometry showed a 16-fold increase in the amount of IgG antibodies and the appearance of an IgM component. Such clinically important HLA antibodies can be detected by extended incubation cytotoxicity and flow cytometric assays prior to becoming reactive in a standard NIH cytotoxicity technique.
A case of hemolytic disease of the newborn due to anti-Kpa
Authors: Costamagna L. , Barbarini M. , Viarengo G.L. , Pagani A. , Isernia D. , Salvaneschi L.
Published: May 2021

A patient with hemolytic disease of the newborn (HDN) due to maternal anti-Kpa alloimmunization is described. Although there are few reports in the literature, it appears that HDN due to anti-Kpa is often mild and transfusion therapy is rarely required. However, in this case, the baby’s hemoglobin progressively decreased and on day 18 a blood transfusion was administered, but jaundice was not severe enough for exchange transfusion.
Evidence that the low-incidence red cell antigens Rla and Lsa are identical
Authors: Kornstad L. , Green C.A. , Sistonen P. , Daniels G.L.
Published: May 2021

Testing of Ls(a-t-) and Rl(a+) red cells with numerous antisera containing antibodies to low-incidence antigens indicated that these antigens are identical. This conclusion was confirmed by adsorption and elution tests, and supported by immunoblotting of Ls(a-t-) and Rl(a+) cells with antibodies to glycophorin C and glycophorin D.
Immunohematology
1996;12:8-10.
Characteristics of anti-Cob in vitro and in vivo: a case study
Authors: Hoffmann J.J.M.L , Overbeeke M.A.M.
Published: May 2021

Serologic and biologic properties of an example of anti-Cob were investigated. The antibody was of the IgG class, and it bound small amounts of complement. It reacted optimally in the albumin-antiglobulin test with little or no enhancement of its reactivity in tests using enzymes. Additional experiments indicated that the Cob antigen is resistant to treatment with chemicals known to destroy other antigens. The antibody caused shortened survival of radiolabeled Co(b+) donor red cells in our patient. At 24 hours, nearly 50 percent of the red cells were no longer detectable in the circulation. It is concluded that anti-Cob is a clinically relevant antibody, a fact that must be taken into account when transfusing patients with anti-Cob

Immunohematology
1996; 12:11-13.
Rhmod phenotype: a parentage problem solved by denaturing gradient gel electrophoresis of genomic DNA
Authors: Steers F.J. , Wallace M. , Mora M. , Carritt B. , Tippett P. , Daniels G.L.
Published: May 2021

Initial Rh phenotyping of a man with hemolytic anemia, his wife, and son appeared to exclude paternity. No exclusion was found in other blood groups or in the human leukocyte antigen (HLA) system; excluding Rh, the paternity index was 98.58 percent. Samples from these three family members, and two other family members, were tested with additional Rh antisera. The results indicated that the propositus has an Rhmod phenotype with expression of c, weak e, and very weak D, E, and G antigens. To support this hypothesis, DNA analysis of the RHD and RHCE genes was performed on the five family members. Polymerase chain reaction (PCR) products from exons 2 and 5 were analyzed by denaturing gradient gel electrophoresis (DGGE). The DNA results corroborated the serologic findings and refuted the exclusion of paternity.
A simple screening method to evaluate the presence of alloantibodies with concomitant warm autoantibodies
Authors: Øyen R. , Angeles M.L.
Published: May 2021

Autoantibodies are present in the serum of patients with autoimmune hemolytic anemia. Extensive serologic investigation is often needed to determine if alloantibodies are also present. To aid in the investigation, a simple method of serum dilution is described. The serum dilution method was compared to allogeneic red blood cell adsorptions in 119 cases tested over a two-year period. In 20 percent of the cases, the same underlying alloantibodies were detected by both the serum dilution method and allogeneic adsorption. In 42 percent of the cases, all autoantibody reactivity was removed by both methods. No clinically significant alloantibodies were missed using serum dilution as compared to allogeneic adsorptions. We conclude that serum dilution is a simple, rapid way to initially assess for the presence of alloantibodies that co-exist with autoantibodies.
Espacialização do grau de vulnerabilidade dos solos da Bacia do Rio Preto, Bahia, Brasil
Authors: Leopoldo Nayara Caroline Moreira , Iwata Bruna de Freitas , Costa Tancio Gutier Ailan , Coelho Juliana Vogado , Clementino Gleide Ellen dos Santos , Toledo Cristian Epifânio de
Published: May 2021

O Cerrado Baiano ou Gerais Baiano, como é comumente citado, abrange importantes unidades territoriais do bioma, as bacias hidrográficas. Essas exercem grande papel ecológico, por serem as principais contribuintes dos afluentes da margem esquerda do Rio São Francisco, na qual garantem uma perene disponibilidade hídrica para múltiplos usos, com destaque para os projetos de irrigação, assim como algumas usinas hidroelétricas do nordeste brasileiro. Nesta perspectiva, a presente pesquisa objetivou especializar os níveis de vulnerabilidade ambiental decorrentes dos processos degradativos do solo na Bacia do Rio Preto, Estado da Bahia, Brasil. Para a determinação da vulnerabilidade dos solos, foram atribuídas notas de risco à degradação para cada um dos critérios (geomorfologia, pedologia, vegetação, geologia e clima, sendo então obtido o mapa de vulnerabilidade da bacia). Após o cálculo dos graus de vulnerabilidade, os dados foram especializados utilizando estatística multivariada pelo uso da Krigagem, por meio do software ArcGIS 10.3, permitindo a distribuição dos graus pelos solos da bacia. Este método permitiu agregar os valores dos componentes ambientais a área da bacia estudada, e desse modo, gerar uma espacialização dos níveis de vulnerabilidade pela área total. O estudo da espacialização dos graus de vulnerabilidade da Bacia do Rio Preto verificou um predomínio em 75% da área total da bacia, do grau de vulnerabilidade calculado de 2,0, decorrente dos elementos do ambiente, com influência predominante da tipologia fitofisionômica da bacia. A análise da vulnerabilidade ambiental permitiu verificar que a Bacia do Rio Preto encontra-se, em sua maior parte, em situação medianamente/estável-vulnerável, o que se torna um fator preocupante, principalmente pelo desenvolvimento das áreas de pastagens e agricultura mecanizada por décadas inseridas nos locais de maior vulnerabilidade ambiental, principalmente nas zona ecotonal de maior susceptibilidade a erosão dos solos, que representam um predomínio em 75% da área total da bacia. O estudo da espacialização da vulnerabilidade da Bacia do Rio Preto utilizando o método de apresentou resultados que podem ser utilizados para estudos de planejamento relativos à questão espacial e ambiental da bacia.
Arborização urbana como política de promoção de saúde e de planejamento urbano: um levantamento das capitais brasileiras
Authors: Bucci Maria Elisa Diniz , Mesquita Carem Aparecida , Sousa Amanda Domingas Ediodato de , Silva Luiz Felipe , Botezelli Luciana
Published: May 2021

A arborização urbana torna as cidades mais saudáveis e sustentáveis, contribuindo para melhoria da qualidade de vida e do bem-estar social. O presente trabalho teve como objetivo analisar os Planos Diretores de Arborização Urbana (PDAU's) pertencentes às capitais brasileiras. A metodologia utilizada buscou caracterizar tais documentos, quantificando-os e verificando sua relevância quanto uma ferramenta de gestão urbana. Os principais resultados demonstraram que 48% dos municípios estudados apresentavam e disponibilizavam estes documentos de forma online, enquanto 41% deles, apesar de prevê-los nas legislações municipais, não foram encontrados e 11% dos municípios não previam e nem apresentavam tais instrumentos. As regiões Norte e Nordeste são as que mais possuem capitais com mais PDAU’s acessíveis. O PDAU do município do Rio de Janeiro-RJ é um documento bastante completo, apresentando todos os parâmetros necessários para a elaboração de um plano setorial deste tipo, enquanto que os de Aracaju-SE e João Pessoa-PB precisam ser revistos pois carecem de informações relevantes para a arborização destes municípios. A presença de PDAU's no Brasil auxiliam no planejamento urbano, uma vez que eles lidam com aspectos urbanísticos essenciais para a melhoria do planejamento urbano, regulando e gerenciando a implantação e a manutenção das árvores presentes nas cidades.
What Helps or Hinders the Learning of Academically Talented Junior Secondary School Boys: The Stories of 123 Boys
Authors: Miller Graeme
Published: May 2021

This paper reports on a 2016-2019 study of 123 students in the most academic Year 9 class in a large, high-achieving New Zealand state boys’ secondary school. The study asked the question: “What aspects of society, schools and teachers, home environment and your own intrapersonal qualities helped or hindered your achievement in at least one academic subject?” Data were gathered through the completion of questionnaires and semi-structured interviews, either in focus groups, or individually. Arguably, the most important findings related to participant perceptions of the greatest influence supporting achievement and the single most common factor identified as hindering achievement. The greatest help was identified to be students’ own intrapersonal characteristics, and the greatest hindrance was identified to be schools and teachers. This paper reports on the main findings of the research with particular emphasis on those with relevance to educators. It also considers what the major implications are for educational practice in New Zealand schools.
Understanding and working with gifted learners: 'They're not bringing my brain out' (Book Review)
Authors: McGregor Marie
Published: May 2021

Two questions that often plague teachers are ‘How can I identify gifted students?’ and ‘How can I best teach gifted students?’ Rosemary Cathcart addresses each of these questions in her book, Understanding and working with gifted learners. “They’re not bringing my brain out”. Cathcart has worked in gifted education since the early 1980s, and in 2005 established Responding to Exceptional Ability in Children (REACH) Education, a specialist education consultancy that offers professional learning for teachers. Understanding and working with gifted learners. “They’re not bringing my brain out” aims to provide anyone an insight into the gifted individual, and presents some practical strategies to identify and respond to the gifted learner.
Pengembangan Media Pembelajaran Matematika dengan Animasi Menggunakan Aplikasi Swishmax
Authors: Charissudin Ahmad , Farida Farida , Putra Rizki Wahyu Yunian
Published: May 2021

Penelitian ini dilakukan bertujuan untuk mengetahui pengembangan, kelayakan, dan kemenarikan dari media pembelajaran matematika dengan animasi menggunakan aplikasi swishmax untuk siswa sekolah menengah pertama kelas VIII. Research and development adalah jenis penelitian yang digunakan dalam penelitian ini dengan memanfaatkan model ADDIE dalam tahapannya. ADDIE adalah Analyze, Desaign, Development, Implimentation, dan Evaluation.Uji coba dalam penelitian ini bertempatkan di MTs Nurul Iman Jati Agung Lampung Selatan. Uji kelayakan dalam penelitian ini dilakukan dengan cara memberika angket kepada para ahli mengenai media pembelajaran yang telah dikembangkan. Hasil yang diperoleh dari para ahli sebesar 3, 43 dan 3, 40 dengan kriteria layak digunakan. Uji kemenarikan dari penelitian ini adalah dengan cara memberikan angket respon peserta didik mengenai media pembelajaran matematika yang telah dikembangkan dan hasil dari angket respon peserta didik yang telah diberikan diperoleh hasil sebesar 3, 42 dengan kriteria menarik. Kemudian dapat disimpulkan bahwa media pembelajaran matematika dengan animasi menggunakan aplikasi swishmax layak dan menarik untuk dimanfaatkan dalam pembelajaran didalam kelas.Kata kunci: media pembelajaran, matematika, Swishmax.
Carwash wastewater treatment using the chemical processes
Authors: Kashi Giti , Younesi Shahrbanou , Heidary Alireza , Akbarishahabi Zeinab , Kavianpour Babak , Rezaei Kalantary Roshanak
Published: May 2021

The carwash is known as one of the most important urban services that brings about the production of huge volume of wastewater with high turbidity and high chemical oxygen demand (COD). Seasonal and carwash location features affect the quality of carwash wastewater. Various methods with special focus on chemical processes have been employed for carwash wastewater treatment and eliminating different pollutants from this wastewater of great concern for the environment. This review was conducted for identifying and comparing the efficiency of chemical processes for carwash wastewater treatment. To this aim, key words were identified and a search protocol was defined to search studies in three databases: Scopus, Web of Science, and PubMed. The results of this systematic review indicated that coagulation (66%) is the most common chemical processes for carwash wastewater treatment. Although chemical processes are able to reduce the turbidity and COD over 80%. Due to the characteristics of carwash wastewater, chemical processes are a necessary pretreatment for processes such as membrane technology. Rapid treatment and high efficiency are the advantages of wastewater treatment by chemical methods, but the energy consumption and sludge volume are two main factors in selection the chemical processes for carwash wastewater treatment.
The emergency management of three pediatric cases of button battery ingestion with complications
Authors: COLAK Ozlem , DERİNOZ Oksan , TOMAR GÜNEYSU Songül
Published: May 2021

Button battery ingestion (BBI) is an increasingly common pediatric condition, both nationwide and worldwide. Management algorithms, including treatment with honey or sucralfate within the first 12 hours, should be prepared for use in the emergency care of patients with suspected BBI without initial complications. In this report, we present three pediatric patients who presented to the emergency department with different symptoms and complications and were diagnosed with BBI.
Challenges of Air-Lines’ Development on the Basis of their Accounting Book Analysis
Authors: Lysenko D. V. , Akgьn L.
Published: May 2021

The article studies the work of Russian air-lines in the current situation of unstable market of air-transportation. The public company ‘Aeroflot’, the industry leader acts as an object of the research. Topicality of the subject is explained by strategic importance of the company development in Russia, as the growth in air-transportation acts as a great stimulus for the Russian economy development. The authors analyzed finance figures of air-lines that show efficiency of their work and came to the conclusion about key reasons of their fluctuations in today’s conditions. On the basis of comparative analysis they identified the air-line, which managed to retain certain finance stability. The article also studies current trends of air-transportation market and on their foundation worked out recommendations by vectors of air-lines’ development. The algorithm of drawing respective conclusions about airlines’ stability and their efficiency was shown by factor analysis of finance figures. Calculations made by the authors according to the proposed methodology of economic analysis are logically substantiated. In article preparation the authors used normative documents, present day literature sources dealing with the subject of the research, articles of academic journals and annual accounting reports of companies. Analysis methodology provided in the article could allow experts to improve the quality of analytical work in the field of economic analysis of air-lines’ operation and optimization of principle figures of their economic functioning.
Insurance Market Transformation in Conditions of Digitalization
Authors: Akhvlediany Yu. T.
Published: May 2021

Digital technologies foster intensification of transformation processes on insurance market. Insurance market development depends on efficient introduction of digital insurance technologies, which give an opportunity to compete with global innovation technologies providing information security on global space. The article studies acute issues of insurance market development in conditions of digital technologies. On the basis of digital insurance analysis the article shows importance of further introduction of digital technologies into insurance industry in order to raise quality of insured’ protection and to develop insurance business in digital economy. The authors came to the conclusion that digital insurance is a result of the stable and effective development of finance market. Factors influencing insurance market development were identified, the impact of COVID-19 epidemic on insurance industry was demonstrated and acute types of insurance in these conditions were studied. The role of finance theory and insurance education in insurance market transformation was described as well as the necessity of system upgrading of education technologies.
Prevelance of Fabella: An MRI Study in The Eastern Anatolia Region of Turkey
Authors: Akdeniz Huseyin , Ozkan Sezai , Adanas Cihan
Published: May 2021

Background:

The fabella, which is generally located in the lateral head of the gastrocnemius muscle, is a sesamoid bone that articulates with the posterior face of the lateral femoral condyle. As traditional information, the prevalence of fabella is between 10–30% in the population and is usually present in both knees.

Introduction:

The objective of this study was to investigate the knee MRIs in the Eastern Anatolia Region of Turkey subjects in order to assess the prevalence of the fabella and analyse the differences between gender, age and laterality and its symmetry pattern.

Methods:

This study was a retrospective study in patients older than 18 years whose knee MRIs were taken between February 2014 and February 2016. In this study, a total of 531 patients (290 females and 241 males) were included. The radiographs were examined by two orthopedic surgeons and the fabella was located. Later, an expert radiologist made the final decision and confirmed the results.

Results:

The number of patients included in the study was 531. We detected os fabella in 59 (11.1%) patients. Of the 59 os fabella, 33 were in the right knee and 26 were in the left knee, 38 were female and 21 were male.

Conclusion:

In this study, we investigated the age and gender differences besides the prevalence and the symmetry pattern of the fabella in the Eastern Anatolia Region of Turkey’s population. Prevalence of the fabella was found to be 11.1% which is different than previously published studies.
Ensemble Adaptive Total Variation Graph Regularized NMF for Singlecell RNA-seq Data Analysis
Authors: Zhu Ya-Li , Gao Ying-Lian , Liu Jin-Xing , Zhu Rong , Kong Xiang-Zhen
Published: May 2021

Background:

Single-cell RNA sequencing techniques have emerged as effective approaches
for finding the heterogeneity between cells and discovering the differentiation stage.
Adaptive total variation graph regularized nonnegative matrix factorization (ATV-NMF) has been
proposed to capture the inner geometric structure and determine whether to retain feature details or
denoise, which is suitable for analyzing single-cell data. However, the rank of matrix factorization
significantly affects clustering performance greatly, and it is still challenging to determine the optimal
rank.

Objective:

To solve the problem, in this paper, we propose an ensemble clustering method ANMFCE
to integrate several base clustering results corresponding to different parameter rank values.

Methods:

Firstly, we use the ATV-NMF algorithm to obtain clustering results with different dimension
reduction ranks. Secondly, the consensus function based on connected-triple-based similarity
is applied to obtain the similarity matrix. Finally, the spectral clustering method is used to
find the final optimal partition.

Results:

Clustering results on six single-cell sequencing datasets show that our method is more advanced
than the individual ATV-NMF method and other comparison methods, which can illustrate
that our method is effective in finding the heterogeneity in single-cell datasets. Moreover, the identification
of gene markers also achieves accurate results.

Conclusion:

In summary, our method is effective for analyzing single-cell RNA sequencing datasets.
Two New Adenosine Derivatives and their Antiproliferative Properties: An In Vitro
Evaluation
Authors: Valdés Francisco , Arévalo Bárbara , Gutiérrez Margarita , García-Castillo Verónica , Salgado-García Rebeca , Pérez-Plasencia Carlos , Valenzuela Claudio , Cayo Ángel , Olate-Briones Alexandra , Brown Nelson
Published: May 2021

Background:

Adenosine is a natural nucleoside present in a variety of organs and tissues, where it acts as a
modulator of diverse physiological and pathophysiological processes. These actions are mediated by at least four G
protein-coupled receptors, which are widely and differentially expressed in tissues. Interestingly, high concentrations
of adenosine have been reported in a variety of tumors. In this context, the final output of adenosine in tumorigenesis
will likely depend on the constellation of adenosine receptors expressed by tumor and stromal cells. Notably, activation
of the A3 receptor can reduce the proliferative capacity of various cancer cells.

Objective:

This study aimed to describe the anti-proliferative effects of two previously synthesized adenosine derivatives
with A3 agonist action (compounds 2b and 2f) through in vitro assays.

Methods:

We used gastric and breast cancer cell lines expressing the A3 receptor as in vitro models and theoretical
experiments for molecular dynamics and determination of ADME properties.

Results:

The antiproliferative effects of adenosine derivatives (after determining IC50 values) were comparable or even
higher than those described for IB-MECA, a commercially available A3 agonist. Among possible mechanisms involved,
apoptosis was found to be induced in MCF-7 cells but not in AGS or MDA-MB-231 cells. Surprisingly, we
were unable to observe cellular senescence induction upon treatment with compounds 2b and 2f in any of the cell lines
studied, although we cannot rule out other forms of cell cycles exit at this point.

Conclusion:

Both adenosine derivatives showed antiproliferative effects on gastric and breast cancer cell lines, and
were able to induce apoptosis, at least in the MCF-7 cell line. Further studies will be necessary to unveil receptor specificity
and mechanisms accounting for the antiproliferative properties of these novel semi-synthetic compounds.
Induction of Divergent Cell Death Pathways by Urea and Carbohydrazide
Derivatives
Authors: Yilmaz Sinem , Tok Fatih , Atalay-Sahar Esra , Kocyigit-Kaymakcioglu Bedia , Ballar-Kırmızıbayrak Petek
Published: May 2021

Background:

The complexity of cancer biology and the development of chemotherapy resistance are
two main obstacles to cancer treatment and necessitate novel anticancer molecules that target different cell death
pathways. Modulation of Endoplasmic Reticulum (ER) stress and subsequent activation of the Unfolded Protein
Response (UPR) has been proposed as a potential chemotherapeutic target, as prolonged ER stress can lead to
cell death via apoptosis or necrosis.

Objective:

The present study aims to evaluate the molecular mechanism underlying the cytotoxic activity of
selected urea and carbohydrazide derivatives.

Methods:

Cell proliferation assays were performed on HeLa, Capan-1, MCF-7, HCC-1937, and MRC-5 cell lines
by WST-1 assay. The expression levels of selected ER stress, autophagy, and apoptosis marker proteins were
compared by immunoblotting to characterize the underlying mechanism of cytotoxicity. Flow cytometry was
used to detect apoptosis.

Results:

Of the tested cytotoxic compounds, 3a, 4a, 5a, 6a, and 1b dramatically and 5b moderately increased ER
stress-related CHOP protein levels. Interestingly, 5b but not 3a, 4a, 5a, 6a, or 1b increased the expression of proapoptotic
proteins such as cleaved PARP-1 and cleaved caspase-3 and -7. The flow-cytometry analysis further
confirmed that the cytotoxic activity of 5b but not the other compounds is mediated by apoptosis, demonstrated
by a significant increase in the percentage of late apoptotic cells (7-AAD/annexin V double-positive cells).

Conclusion:

Our results suggest that changing a substituent from trifluoromethyl to nitro in urea and
carbohydrazide core structure alters the cell death mechanism from apoptosis to an apoptosis-independent cell
death pathway. This study shows an example of how such simple modifications of a core chemical structure
could cause the induction of divergent cell death pathways.
Cloud/edge Computing and Big Data System with 6G
Authors: Yu Peng , Shi Lei
Published: May 2021

This chapter gives a systematic introduction to cloud/edge computing and
big data system. Cloud computing provides the ability to use flexible and telescopic
services for cloud users and could implement through various hosted services provided
by the Internet. Edge computing refers to the open platform which uses the network,
computing, storage, and application core capabilities on the side of the object or data
source and provides the nearest end service to avoid the relatively long delay to reach
the data cloud center. Big data technology refers to the analysis of potentially useful
information from a large number of data. Analysis of big data can get hidden patterns,
unknown relevance, customer trends, and other messages to ensure comprehensive data
management. In addition, the speed of 6G is faster, and its service field becomes more
extensive compared with the previous generation communication technologies, which
makes 6G play a more important or extensive role in the future of the technology field
and society. In this regard, the authors also analyze the effect of 6G on cloud/edge
computing and big data system. According to the future users' demand for 6G and the
characteristics of 6G itself, cloud/edge computing and big data system will play an
irreplaceable role in achieving high efficiency and benefits.
Cuantificación práctica del bienestar animal en porcinos de pequeños productores del sur de Veracruz, México
Authors: Hernández-Antonio Hanssel Iván , Vázquez-Luna Dinora , Lara-Rodríguez Daniel Alejandro , Martínez-Martínez Marina
Published: May 2021

Objetivo. Cuantificar el bienestar animal en porcinos de pequeños productores en comunidades del sur de Veracruz. Materiales y métodos. Se realizó un estudio en diez unidades de producción, donde se llevó a cabo un diagnóstico y se analizaron diez variables en los rubros de alimentación, alojamiento, salud y comportamiento de los lechones, de acuerdo con el protocolo Welfare Quality® de la Unión Europea y ponderado de 0 a 1, donde 0= nulo, 0.5= regular y 1= ideal bienestar animal. Resultados. La relación humano-animal fue satisfactoria; sin embargo, existió bajo confort térmico ligado al tipo de instalaciones. Los principales indicadores de bienestar animal fueron alimentación 0.9±0.235, alojamiento 0.6±0.319, salud 0.7±0.252 y comportamiento 0.9±0.192. Conclusiones. La cuantificación del bienestar animal permite identificar de forma práctica aspectos de manejo que los productores han desarrollado de forma intrínseca como la relación humano-animal y la limpieza de las instalaciones. El bienestar animal puede ser cuantificado de forma práctica, ofreciendo alternativas de manejo a los productores, quienes desarrollan actividades adecuadas (limpieza frecuente de las instalaciones) y no adecuadas (alimentación con bajo aporte de proteína, corte de cola y castración).