bluuebunny/crossref_metadata_2025 huggingface dataset:
Laboratory assessment for determining microplastics in freshwater systems – characterization and identification along Somesul Mic River
Authors: Gheorghe Stefania , Stoica Catalina , Harabagiu Anca Maria , Neidoni Dorian-Gabriel , Mighiu Emanuel Daniel , Bumbac Costel , Ionescu Ioana Alexandra , Pantazi Aida , Enache Laura Bianca , Enachescu Marius
Published: November 2023

Microplastics (MPs) pollution has become a persisting problem over the last decades and a critical issue for environmental protection and human health. In this context any scientific data able to reveal the MPs presence and to improve the characterization and identification in different systems is valuable. The aim of this paper was to assess available techniques for determining MPs in real freshwater samples and subsequently to highlight the occurrence and type of MPs in the study case area (Somesul Mic River). The specific objectives of the study were: i) MPs separation and visual characterization; ii) microscopic analyses and morphological characterization of MPs; iii) Raman and FT-IR spectroscopic identification of MPs.
MPs sampling was performed from the fresh water and sediment using planktonic nets and sieves with different mesh sizes (20 to 500µm). After digestion with hydrogen peroxide, the MPs characterization was performed using both classical microscopic techniques as well as scanning electron microscopy (SEM). For the MPs identification, Raman and FT-IR spectrometry techniques were used. Large (1-5 mm) and small (1 µm to 1 mm) MPs were observed in the shape of fibers, fragments, foam, foils and spheres in various colors (red, green, blue, purple, pink, white, black, transparent, opaque). Polymers were identified related to scientific literature and reference spectra. The presence of polyethylene (PE), polypropylene (PP) and polystyrene (PS) was registered for all sampling point.
The MPs laboratory investigations have raised some issues regarding the identification of MPs particles with the size smaller than 500µm, being characterized especially under microscope. Small MPs particle dispersed on cellulose filter were identified using micro-Raman spectroscopy highlighting the same type of polymers. The results showed that both spectrometric methods Raman or FT-IR confirm the identification of the same type of polymers. No differences were registered between the sampling points due to the widespread presence of MPs. The sediments samples presented a greater abundance compared to the water samples. Overall, it is necessary to continue the optimization of the MPs separation protocol and identification according to the complexity of samples, mainly due to the limitation and lack of spectral databases.
The Heteromorphic Approach to Adjunctions: Theory and History
Authors: Ellerman David
Published: November 2023

Mallios and Zafiris emphasize that adjoint functors or adjunctions are not only "ubiquitous" in category theory but characterize the naturality of their approach to physical geometry. Hence in this paper, the history and theory of adjoint functors is investigated. Where do adjoint functors come from mathematically and how did the concepts develop historically?
Experimental Thermal Conductivity Measurement of Hollow Structure Polypropylene Material By DTC-25 and Hot Box Test
Authors: Osaze Osasu , Khanna Sanjeev
Published: November 2023

Experimental measurement of porous polypropylene (PP) using the DTC-25 TA laboratory equipment and hot box test has been compared. The thermal conductivity of materials indicates the insulation capability of building materials. Excellent building materials will have a lower thermal conductivities value as well as other building insulator performance metrics. While results show that increasing the volume fraction of fluid in the porous PP has an inverse association with the thermal conductivity of the material as predicted by porous media theories, there is a marked difference in the measured values of the thermal conductivity using the two methods. The thermal conductivity values of porous from DTC-25 and hot box test were 0.21 and 0.0033 W/mK, respectively. The difference in the thermal conductivity values was due to the misapplication of the Fourier’s guarded heat flow model in the DTC-25 device to a convective fluid porous medium material.
Study on Optimization Method of Polarization Balance for Weak Starlight System
Authors: Wu Linghao , Sun Jingrui , Ou Sicheng , Sheng Lan , Wang Jiaan
Published: November 2023

The accuracy of star position simulation is the key factor affecting the accuracy of ground calibration test of spacecraft attitude measurement system. To solve the impact of nonimaging polarized stray light on the simulation accuracy of star position in the optical engine of the system, the generation mechanism of non-imaging polarized stray light has been investigated, and an optimization method for polarization balance of the optical engine is proposed. The mathematical model of the incident light aperture angle and the ideal polarization parameter of the optical engine thin film is established, and the optimization evaluation function of polarization balance of the optical engine is constructed. An optical engine polarization balance film with the corresponding full-band binomial attenuation is <0.001 and the phase delay is <1°. Experimental results show that the simulation accuracy of the weak starlight simulation system is improved by 1.64 times using polarization balanced optical engine.
Comprehensive Histopathological and Immunohistochemical Evaluation of African Swine Fever in Romanian Swine: Insights into Pathogenesis and Diagnostic Strategies
Authors: Ungur Andrei , Nagy Andras-Laszlo , Cătoi Cornel
Published: November 2023

African Swine Fever (ASF) poses a significant threat to domestic pig populations worldwide. This study investigates the histopathological alterations in confirmed ASF-positive domestic pigs, focusing on over 100 cases from 2018 to 2021. Biological material from 118 pigs, confirmed ASF-positive via PCR examination, was histopathologically examined. Tissue samples from various organs were processed, embedded, and analyzed using hematoxylin and eosin staining. Immunohistochemistry (IHC) was employed to detect the major capsid protein (p72) of the ASF virus.Histological examination revealed characteristic ASF lesions, including severe hemorrhages, lymphoid depletion, and inflammatory infiltrates. Vascular anomalies leading to hemorrhagic events were widespread. Microthromboses were prevalent in lymph nodes and kidneys. IHC detected p72 in various organs, with tonsils consistently showing the highest viral presence.This comprehensive study underscores the pivotal role of lymph nodes, spleen, and kidneys in ASF pathogenesis, highlighting prominent vascular involvement and hemorrhagic manifestations. The study establishes the efficacy of IHC in detecting ASF virus, even in autolyzed tissue samples. Tonsils emerge as a consistent epicenter of viral presence, shedding light on the intricate pathogenesis of ASFV.
Fluvastatin Converts Human Macrophages into Pro-inflammatory Foam Cells with Therapeutic Potential in Tuberculosis
Authors: Montero-Vega M.Teresa , Matilla Joaquin , Bazán Eulalia , Reimers Diana , De Andrés-Martín Ana , Gonzalo-Gobernado Rafael , Correa Carlos , Urbano Francisco , Gómez-Coronado Diego
Published: November 2023

Cholesterol biosynthesis inhibitors (statins) protect hypercholesterolemic patients from developing active tuberculosis, suggesting that these drugs could help the host to control the pathogen at the initial stages of the disease. This work studies the effect of fluvastatin on the early response of healthy peripheral blood mononuclear cells (PBMC) to inactivated Mycobacterium tuberculosis (Mtb) H37Ra. We found that in fluvastatin-treated PBMC, most monocytes/macrophages became foamy cells that overproduce NLRP3 inflammasome components in the absence of immune stimulation, evidencing important cholesterol metabolism/immunity connections. When both fluvastatin-treated and untreated PBMC were exposed to Mtb, a subset of macrophages quickly captured large amounts of bacilli and died, concentrating the bacteria in necrotic areas. In fluvastatin-untreated cultures, most of the remaining macrophages became epithelioid cells that isolated these areas of cell death in granulomatous structures that barely produced IFN-gamma. By contrast, in fluvastatin-treated cultures, foamy macrophages surrounded the accumulated bacteria to degrade them, markedly activated caspase-1 and elicited a potent IFNgamma/cytotoxic response. In rabb-gammaits immunized with the same bacteria, fluvastatin therapy increased the tuberculin test response. We conclude that statins enhance macrophage effectiveness to control Mtb supported by adaptive immunity, offering a promising tool in the design of alternative therapies to fight tuberculosis.
Machine Learning-Based Prediction of Intrauterine Growth Restriction and Preeclampsia: A Prospective Study
Authors: Scripcariu Ioana Sadiye , Vasilache Ingrid Andrada , Pavaleanu Ioana , Doroftei Bogdan , Cărăuleanu Alexandru , Socolov Demetra , Melinte-Popescu Alina-Sinziana , Vicoveanu Petronela , Harabor Valeriu , Mihalceanu Elena , Melinte-Popescu Marian , Harabor Anamaria , Stuparu-Cretu Mariana , Nemescu Dragos
Published: November 2023

1) Background: The screening of preeclampsia (PE) and intrauterine growth restriction (IUGR) represents a constant challenge for obstetricians. The aim of this study was to determine and compare the predictive performance of 4 machine learning-based algorithms for the prediction of PE, IUGR, and their association in a cohort of singleton pregnancies; (2) Methods This prospective study was conducted at a tertiary maternity hospital in Romania, and included 210 pregnancies that underwent first trimester screening. We included clinical and paraclinical data into 4 machine learning-based algorithms decision tree (DT), naïve Bayes (NB), support vector machine (SVM), and random forest (RF), and calculated their predictive performance; (3) Results: RF performed the best when used to predict PE, IUGR, and its subtypes, as well as the association between PE and IUGR. The overall predictive performance of DT for all these disorders was inferior to RF, NB, and SVM. Both SVM and NB had similar accuracy for the prediction of PE, while NB performed better than SVM for the prediction of IUGR; (4) Conclusions: Machine-learning-based algorithms could be useful for the prediction of ischemic placental disease and need to be validated on large cohorts of patients.
Which Statistical Test Should We Use for 2 x 2 Tables?
Authors: Cahusac Peter
Published: November 2023

Categorical data analysis of 2 x 2 contingency tables is extremely common, not least because they provide odds and risk ratio statistics in medical research. The χ2 test is most often used, although some researchers use the likelihood ratio test (LRT). Does it matter which test is used? This paper argues that the LRT rather than the χ2 test should be used when we are interested in testing whether two variables are independent, as is typically the case. In contrast, the χ2 test should be reserved for where the data appear to match too closely a particular hypothesis (e.g. the null hypothesis), as may occur in the investigation of data integrity. Finally, it is argued that the evidential approach provides a consistent and coherent way in which tests can be made for each of these situations.
Investigating Soil Water Retention and Hydrological Properties in Retrogressive Thaw Slumps in the Qinghai-Tibet Plateau, China
Authors: Sun Haitao , Wang Pei , Xing Yuhua , Zhang Dapeng , Li Siying
Published: November 2023

Retrogressive thaw slumps (RTSs) are becoming more common on the Qinghai-Tibet Plateau as permafrost thaws, but the hydraulic characteristics of these slumps have not been extensively studied. To fill this knowledge gap, we used the ''space-for-time substitution method'' to differentiate three stages of RTSs: original grassland, collapsing, and collapsed. Our study included on-site investigations, measurements, and simulated analyses of soil water characteristics, environmental factors, and hydrological properties. Our findings show that the measurements and simulated analyses of soil water characteristics were highly consistent across RTSs, indicating the accuracy of the V-G model in reproducing soil hydraulic parameters for different stages of RTSs. The original grassland stage had the highest soil water retention and content due to its high SOM content and fine-textured micropores. In contrast, the collapsed stage had higher soil water retention and content compared to the collapsing stage, primarily due to increased proportions of soil micropores, SOM content, and lower bulk density (BD). Freeze-thaw cycles had a significant impact on the soil texture and structure of RTSs, resulting in a decrease in SOM content and an increase in BD. However, the absence of soil structure and compaction led to the subsequent accumulation of organic matter, increasing SOM content. Changes in field capacity (FC), permanent wilting point (PWP), and soil micropore distribution aligned with variations in SOM content and water content.These findings highlight the importance of managing SOM content and water content to mitigate the adverse effects of freeze-thaw cycles on soil structure and stability at different stages of RTSs. Effective management strategies may include incorporating organic matter, reducing soil compaction, and maintaining optimal water content. Further research is needed to determine the most suitable management practices for different soil types and environmental conditions.
Unlocking the Potential of Therapy-Induced Cytokine Responses: Illuminating New Pathways in Cancer Precision Medicine
Authors: Gunturu Dilip Reddy , Hassan Mohammed , Bedi Deepa , Datta Pran K , Manne Upender , Samuel Temesgen
Published: November 2023

Precision cancer medicine primarily aims to identify individual patient genomic variations and exploit vulnerabilities in cancer cells to select suitable patients for specific drugs. These genomic features are commonly determined by gene sequencing prior to therapy, to identify individuals who would be most responsive. This precision approach in cancer therapeutics remains a powerful tool that benefits a smaller pool of patients, sparing others from unnecessary treatments. A limitation of this approach is that proteins, not genes, are the ultimate effectors of biological functions, and therefore the targets of therapeutics. An additional dimension in precision medicine that considers an individual’s cytokine response to cancer therapeutics is proposed. Cytokine responses to therapy are multifactorial and vary among individuals. Thus, precision is dictated by the nature and magnitude of cytokine responses in the tumor microenvironment exposed to therapy. This review highlights cytokine responses as modules for precision medicine in cancer therapy, including potential challenges. For solid tumors, both detectability of cytokines in tissue fluids and their being amenable to routine sensitive analyses could address the difficulty of specimen collection for diagnosis and monitoring. Therefore, in precision cancer medicine, cytokines offer rational targets that can be utilized to enhance the efficacy of cancer therapy.
IgG Antibody Responses to Epstein-Barr Virus in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Their Effective Potential for Disease Diagnosis and Pathological Antigenic Mimicry
Authors: Fonseca André , Szysz Mateusz , Ly Hoang Thien , Cordeiro Clara , Sepúlveda Nuno
Published: November 2023

The diagnosis and the pathology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) remain under debate. However, there is a growing body of evidence for an autoimmune component in ME/CFS caused by the Epstein-Barr virus (EBV) and other viral infections. In this work, we took advantage of a large public dataset on the IgG antibodies to 3,054 EBV peptides to understand whether these immune responses could be used as putative biomarkers for disease diagnosis and triggers of pathological autoimmunity in ME/CFS patients using healthy controls (HCs) as a comparator cohort. We then aimed at predicting disease status of study participants using a Super Learner algorithm targeting an accuracy of 85% when splitting data into train and test datasets. When we compared data of all ME/CFS patients or data of a subgroup of these patients with non-infectious or unknown disease trigger to the dataset of HC, we could not find an antibody-based classifier that would meet the desired accuracy in the test dataset. In contrast, we could identify a 26-antibody classifier that could distinguish ME/CFS patients with an infectious disease trigger from HCs with 100% and 90% accuracies on the train and test sets, respectively. We finally performed a bioinformatic analysis of the EBV peptides associated with these 26 antibodies. We found no correlation between the importance metric of the selected antibodies in the classifier and the maximal sequence homology between human proteins and each EBV peptide recognized by these antibodies. In conclusion, these 26 antibodies against EBV have an effective potential for disease diagnosis of a subset of patients, but they are less likely to trigger pathological autoimmune responses that could explain the pathogenesis of ME/CFS.
Copper in Gynecological Diseases
Authors: Conforti Rocío Ayelem , Delsouc María Belén , Zorychta Edith , Telleria Carlos M , Casais Marilina
Published: November 2023

Copper (Cu) is an essential micronutrient for the correct development of eukaryotic organisms. This metal plays a key role in many cellular and physiological activities, including enzymatic activity, oxygen transport, and cell signaling. Although the redox activity of Cu is crucial for enzymatic reactions, this property also makes it potentially toxic when found at high levels. Due to this dual action of Cu, highly regulated mechanisms are necessary to prevent both the deficiency and the accumulation of this metal since its dyshomeostasis may favor the development of multiple diseases, such as Menkes’ and Wilson’s diseases, neurodegenerative diseases, diabetes mellitus, and cancer. As the relationship between Cu and cancer has been the most studied, we analyze how this metal can affect three fundamental processes for tumor progression: cell proliferation, angiogenesis, and metastasis. Gynecological diseases are characterized by high prevalence, morbidity, and mortality, depending on the case, and mainly include benign and malignant tumors. The cellular processes that promote their progression are affected by Cu, and the mechanisms that occur may be similar. We analyze the crosstalk between Cu deregulation and gynecological diseases, focusing on therapeutic strategies derived from this metal.
National Burden and Trends for 29 Groups of Cancer in Mexico from 1990 to 2019: A Secondary Analysis of the Global Burden of Disease Study 2019
Authors: Beltran-Ontiveros Saul A. , Contreras-Gutierrez Jose A. , Lizarraga-Verdugo Erik , Gutierrez-Grijalva Erick P , Lopez-Lopez Kenia , Lora-Fierro Emilio H. , Trujillo-Rojas Miguel A. , Moreno-Ortiz Jose M. , Cardoso-Angulo Diana L. , Leal-Leon Emir , Zatarain-Lopez Jose R. , Cuen-Diaz Hector M. , Montoya-Moreno Marisol , Arce-Bojorquez Brisceyda , Rochin-Teran Jose L. , Cuen-Lazcano Daniel E. , Contreras-Rodriguez Victor A. , Lascurain Ricardo , Carmona-Aparicio Liliana , Coballase-Urrutia Elvia , Gallardo-Vera Francisco , Diaz Daniel
Published: November 2023

The cancer burden is increasing worldwide with contrasting national patterns. Therefore, providing national estimations is necessary to understand and control this health issue. Herein, we comparatively describe incidence, mortality, and disability-adjusted lived years (DALYs) due to 29 groups of cancer in Mexico from 1990 to 2019 by sex and age. Using public data from the Global Burden of Disease Study 2019, we assessed the national burden of cancer using counts and crude and age-standardized rates per 100,000 people with 95% uncertainty intervals for 2019 and their trends using the annual percentage of change from 1990 to 2019. In 2019, cancer caused 222,060 incident cases, 105,591 deaths, and 2,86,054 DALYs in the general population. Nonmelanoma skin cancer, prostate cancer, and breast cancer had the highest incidence, and six groups of cancer (lung, colorectal, stomach, prostate, breast, and pancreatic) caused 53% of the deaths in 2019. From 1990 to 2019, incidence and mortality showed an increasing trend that varied between 10% and 436% among the groups of cancer, whereas the crude and age-standardized rates showed cancer-specific sex disparities. Our results demonstrate a substantial growth of the national burden of cancer with sex-specific patterns of change. These results may guide national efforts toward reducing health loss due to cancer.
Molecular Docking Analysis of Flavonoid Compounds from Glycyrrhiza glabra on the Interleukin – 1 Receptor (IL-1R) as a Candidate for Anti-Inflammatory Drug in Periodontitis
Authors: Auerkari Elza Ibrahim , Andriawan Samantha Ruth , Auerkari Pertti
Published: November 2023

Periodontitis is a disease that originates from gingival tissue, and if left untreated, can cause inflammation to spread to deeper tissues, altering bone homeostasis, and even leading to tooth loss. When the bacteria in plaque reach sufficient numbers, the immune system responds by activating immune cells that will produce cytokines, including interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α). These immune signaling molecules will coordinate the inflammatory responses. IL-1 binds to the IL-1 receptor (IL-1R) on the surface of target cells, initiating an inflammatory response by activating intracellular signalling pathways. Inhibition of IL-1R can prevent the interaction of IL-1 with this receptor, thereby halting the activation of the inflammatory pathway. By substituting this connection with active anti-inflammatory substances, it is possible to prevent the contact between IL-1 and IL-1R. The licorice plant, Glycyrrhiza glabra, includes eight types of flavonoids with significant anti-inflammatory potential, namely isoliquiritigenin, glyzaglabrin, prunetin, shinpterocarpin, licochalcone A, glabridin, glisoflavone, and isoangustone A. This study aims to assess the potential of such flavonoids as candidates for periodontitis treatment through molecular docking, using AutoDock Tools v.1.5.6. All tested compounds showed highly stable bonds to IL-1R, with a binding affinity values below -7 kcal/mol. Van der Waals forces, hydrogen bonds, and hydrophobic bonds all contribute to the stability of these interactions. Among the eight tested compounds, glisoflavone, which has a Ki value of 90.89 nM and a ΔG value of -9.61 kcal/mol, has the highest binding stability to IL-1R.
Nutraceutical Benefits for Bone Health: Role in Osteoporosis Prevention
Authors: Roseti Livia , Borciani Giorgia , Grassi Francesco , Desando Giovanna , Gambari Laura , Grigolo Brunella
Published: November 2023

Osteoporosis is characterized by low bone mass and structural deterioration of bone tissue with increased risk of fracture. The population that is most at risk for primary osteoporosis in-cludes post-menopausal women.
Among different approaches, nutraceuticals are increasingly popular in developed countries since can contribute to bone health and can delay the onset of pathological bone loss.
Our review covers three main aspects. Firstly, we discuss the current state of the two con-ditions, osteopenia, and osteoporosis. Secondly, we focus on the latest developments in natural Nutraceuticals and their effectiveness in reducing bone loss. Finally, we conduct a Strengths, Weaknesses, Opportunities, and Threats (SWOT) analysis to examine the pros and cons of Nutraceuticals assumption.
Nutraceuticals hold great promise, but we must address challenges such as regulatory control and experimental evidence to fully realize their potential. Other challenges include identifying the source of raw materials, ensuring the purity of the compound, avoiding contamination or the presence of other active compounds, maintaining product quality, and preventing interactions with other elements or drugs.
By addressing these challenges, the scientific community can ensure more reliable indica-tions for the use of Nutraceuticals and help people lead healthier lives.
PENERAPAN PRINSIP KYC PADA FINANCIAL TECHNOLOGY P2P LENDING YANG AKOMODATIF BAGI PERLINDUNGAN KONSUMEN
Authors: Khafialima Zahra Rally Nufi , Tejomurti Kukuh
Published: November 2023

Abstract

This article aims to know the legal problem and solution for FinTech P2P Lending Company that is not doing verification or rechecking their Borrowers. This type of article is normative legal research that is prescriptive to find a new concept for resolving the legal problem by using the statute approach. This article uses secondary data with primary legal material and library research. The data analysis technique used by the author is a deduction and syllogism analysis. The result of this research is a Borrower who committing fraud by using other person’s identity or fake account can be found because of personal data leaks dan sells personal data by social media. Moreover, fake account on P2P Lending also caused by FinTech P2P Lending Company who is not using KYC Principles as appropriate in the bank or not rechecking their Borrowers. A solution for FinTech P2P Lending Company who wants to apply KYC Principles in their P2P Lending platform is using e-KYC.

Keywords: Fake accounts; e-KYC; P2P Lending

Abstrak

Artikel ini bertujuan untuk mengetahui akibat hukum serta solusi bagi Penyelenggara FinTech P2P Lending yang tidak melakukan verifikasi atau pemeriksaan ulang terhadap Penerima Pinjamannya. Artikel ini termasuk ke dalam jenis penelitian normatif yang bersifat preskriptif untuk menemukan konsep baru guna menjawab isu hukum yang dihadapi dengan menggunakan pendekatan perundang-undangan. Data yang digunakan dalam artikel ini merupakan data sekunder dengan bahan hukum primer yang menggunakan teknik pengumpulan data hukum kepustakaan. Teknik analisis data yang digunakan oleh penulis adalah teknik analisis data yang bersifat deduksi dengan metode silogisme. Hasil penelitian menunjukkan bahwa terdapat Penerima Pinajaman yang melakukan penipuan identitas atau munculnya akun palsu yang disebabkan adanya kebocoran data pribadi dan praktik jual-beli data pribadi pada media sosial. Selain itu, munculnya akun palsu pada P2P Lending juga disebabkan karena Penyelenggara FinTech P2P Lending tidak menerapkan prinsip KYC layaknya perbankan atau melakukan pemeriksaan ulang terhadap Penerima Pinjamannya. Solusi bagi Penyelenggara FinTech P2P Lending yang ingin menerapkan prinsip KYC pada platform P2P Lending miliknya adalah dengan menggunakan e-KYC.

Kata Kunci: Akun palsu; e-KYC; P2P Lending
PROBLEMATIK HUKUM PENERAPAN CURRENCY BOARD SYSTEM DI INDONESIA
Authors: Suryaprabaswara Muhammad Excel , Pujiyono .
Published: November 2023

This article describes and examines the problem. First, how is the legal problematic if the application of the Currency Board System is carried out in Indonesia. Based on the results of the research, it shows that the problems found are that the Law of the Republic of Indonesia Number 6 of 2009 concerning the Second Amendment to Law Number 23 of 1999 concerning Bank Indonesia and Law Number 24 of 1999 concerning Foreign Exchange Flows and the Exchange Rate System have not accommodated application of the Currency Board System. The law clearly stipulates that Indonesia only adopts a floating exchange rate system. The response from banking law experts calls for the need for a new law and / or amendments to the old law, namely Law of the Republic of Indonesia Number 6 of 2009 concerning the Second Amendment to Law Number 23 of 1999 concerning Bank Indonesia and Law Number 24 of 1999 concerning Foreign Exchange Flows and Exchange Rate System.
IMPLIKASI DAN MEKANISME EKSEKUSI OBJEK JAMINAN FIDUSIA PASCA PUTUSAN MAHKAMAH KONSTITUSI NO.18/PUU-XVII/2019 DALAM HAL DEBITUR WANPRESTASI
Authors: Meiliana Brigita Cindy , Suryono Arief
Published: November 2023

This article aims to find out the legal implications of the Constitutional Court Decision No.18 / PUU-XVII / 2019 and the mechanism for the execution of fiduciary object guarantees after the Constitutional Court Decision No.18 / PUU-XVII / 2019. This type of research is normative with the nature of applied and prescriptive research. Based on the results of research and discussion, the most important implications  are  the  reduced  executive  power  of  fiduciary  certificates,  the elimination  of  the  parate  execution  mechanism,  and  inefficiency  in  handling fiduciary guarantee disputes. Meanwhile, the mechanism is longer and more complicated.
TANGGUNG JAWAB PERDATA PARA PIHAK DALAM PERDAGANGAN MELALUI SISTEM ELEKTRONIK PADA STARTUP MULTINASIONAL LAZADA DALAM PERSPEKTIF HUKUM E-COMMERCE DI INDONESIA
Authors: Pisarta Clara Beatrice , Kharisma Dona Budi
Published: November 2023

This article aims to analyze the civil liability of the parties at Lazada if there is default in the online sale and purchase agreement in relation to the law of e-commerce in Indonesia. And to see the legal protection of Lazada's online buying and selling agreements with e-commerce laws in Indonesia. This research is a descriptive normative legal research. The approach used is a statue approach. The materials used in the study were selected from primary legal materials and secondary legal materials using techniques and data in the form of literature study. In analyzing legal 

materials and in data analysis techniques used the syllogism method. Based on the research results, there is still a lack of explanation in the electronic contracts at Lazada about civil liability and existing repressive legal protections. It is hoped that the government will provide assertiveness through good preventive legal protection and for Lazada to tidy up the class and the contents of the agreement.
PERJANJIAN PERDAMAIAN UNTUK MENCIPTAKAN KONSEP CORPORTAE RESQUE DALAM RESTRUKTURISASI SEMI PUBLIK INSOLVENCY LAW DI ERA BISNIS MODERN
Authors: Dewi Putri Maha , Septiningsih Ismawati , Kurniawan Itok Dwi
Published: November 2023

Many companies face the threat of difficulty paying their debts to their creditors. There are many reasons the debtor has not paid off the debt, including being unable to pay off the debt that has been given at all, the debt that has been paid is still insufficient for the debt bill, being late in paying the debt, or paying the debt but not in accordance with what has been agreed. The reconciliation plan in the PKPU contains one of which is the debtor's plan to restructure his debts in accordance with the principle of business continuity, which most often is rescheduling, regulated in Article 265 of Law Number 37 of 2004 concerning Bankruptcy. The parties are free to determine the content of the peace plan, the freedom of the content of this peace plan is known as the principle of freedom of contract. The peace agreement which has been ratified by the court, then the reconciliation has binding legal force for the Debtor and the Creditors.
ARITHMETIC MEAN HEIGHT AND MAXIMUM HEIGHT OF THE ROUGHNESS PROFILE IN HONING WITH DIFFERENT FEEDS
Authors: Sztankovics István
Published: November 2023

The achievable surface quality is an important factor even in roughing procedures; however, it is most relevant in finishing. Two commonly measured and analysed characteristics of the machined surface roughness profile are the Arithmetic Mean Height and the Maximum Height of the Roughness Profile. In this paper these parameters were studied in bore honing. Cutting experiments were carried out, where the feed rate and the applied honing tool are varied. After the evaluation of the measured 2D surface profiles, the following conclusions were drawn: the effect of the feed rate is not linear; the lowest values of the analysed roughness parameters were achieved by the application of 50 mm/rev. feed rate and a honing tool with 80 grain size and ceramic binder; the difference between the studied roughness parameters was 6.5-8.0-fold.
INVESTIGATION OF ELECTRO DISCHARGE MACHINING OF TOOL STEELS BASED ON THE ROUGHNESS OF THE MACHINED SURFACES
Authors: Maros Zsolt , Kun-Bodnár Krisztina , Fekete Vivien
Published: November 2023

In electro discharge machining (EDM or spark erosion) the roughness of the machined surface plays a very important role in the applicability of the process. This paper deals with a comparative study of the electro discharge machining of tool steels based on the roughness characteristics of the machined surfaces. Another aim of the research is to investigate which tool materials (electrode material, copper, or graphite) are most effective to achieve the best possible surface microgeometry. Based on the data of the performed cutting experiments and the subsequent measurements, conclusions will be drawn regarding the machinability of the tested tool steels and the applicability of the electrode materials used.
Techniques and Steps of Islamic Education Learning Development: Integration of Islamic Values in Learning
Authors: Hidayat Tatang , Rizal Ahmad Syamsu , Abdussalam Aam , Istianah Istianah
Published: November 2023

The reality of learning in the materialism education system eliminates religious values that cause dry learning of divine values. The purpose of this study was to determine the techniques and steps of developing PAI learning through the integration of Islamic values in learning. This research uses a qualitative approach and literature study method. Data retrieval techniques come from primary sources and secondary sources with 6 months of searching for references. Data analysis technique with data interpretation. Based on the results of the discussion, learning is an art and science. Learning is a process of issuing all efforts both materials, methods, and media for the creation of systematic learning and teaching activities starting from planning, implementation, and evaluation to enable students to achieve learning objectives effectively and efficiently. The purpose of learning is to foster humans to be able to optimize their potential (jasadiyyah, aqliyyah, and ruhiyyah) in an integrative and comprehensive manner so as to increase the growth of innovative, creative thinking, proactive communication which includes activities of creativity, reflectivity, reciprocity, and responsibility arranged in appropriate systematic steps in the learning process. The results of this study have implications for the techniques and steps for developing PAI learning by integrating Islamic values in learning.
Impact of material stiffness on the dynamic wetting and deformation of soft matter hemiwicking arrays
Authors: Putnam Shawn , Germain Thomas
Published: November 2023

Throughout the last few decades, a significant amount of research has been conducted on the wetting and deformation of soft materials. Employing high-speed videography, we report the spatiotemporal wetting and hemiwicking velocities for different fluids with micropillar hemiwicking arrays of various pillar geometries, spacing configurations, and Young's moduli ranging from E = 61 kPa to 12 GPa. The wetting and wicking dynamics are analyzed with comparisons to that predicted by contemporary scaling laws or derived analytic solutions. The results show that our analytical models can predict the inertial wetting, deformation, and hemiwicking dynamics within typically <50% of that experimentally observed. For the wide range of sample-fluid couples studied, the upper-limit (maximum) hemiwicking and inertial wetting velocities are typically observed within the narrow ranges of 10~30 mm/s and 0.8~1.6 m/s, respectively. Aside from the ultrasoft (~61 kPa) Ecoflex sample, sample stiffness had no notable effect on the maximum speed that a fluid can wet the non-textured surface region. However, for soft materials with elastic moduli below ~150 kPa, the rapid coupling between transient swelling and elastocapillary deformations leads to recoil wetting and wicking dynamics and notable reductions in the hemiwicking velocity.
Pneumocystis jiroveci pneumonia secondary to blinatumomab therapy: a case report
Authors: Yin Yue , Shen Kaini , Li Hanyu , Zhang Lu
Published: November 2023

Background
With the increasing use of Blinatumomab in relapsed or refractory, as well as MRD-positive, B-cell precursor acute lymphoblastic leukemia (ALL), the recognition of its adverse effects has gradually improved, in which pneumocystis jiroveci pneumonia (PCP) is rare.
Case presentation
We present a case of PCP in patients undergoing Blinatumomab therapy. A 70-year-old female patient diagnosed with Philadelphia-like, CRLF2 overexpression B-cell precursor ALL received Blinatumomab as consolidation therapy after achieving complete remission with prior induction chemotherapy. On the second day of Blinatumomab infusion, she developed intermittent low-grade fever with chest computed tomography revealing subtle infiltrates and nodules. Though empirically treated with trimethoprim-sulfamethoxazole (TMP-SMX) for PCP prophylaxis, she progressed to significant shortness of breath and type I respiratory failure, with increased lactate dehydrogenase and β-D-glucan assays. Chest computed tomography showed diffuse ground-glass opacities with scattered small nodules. Because of dry cough, next-generation sequencing of peripheral blood was tested and showed positive for pneumocystis jiroveci without evidence of other pathogens. Consequently, the patient was diagnosed with PCP. The first cycle of Blinatumomab had to be discontinued, and therapeutic dosages of TMP-SMX and dexamethasone were administered, followed by a full recovery and stable station during follow-ups.
Discussion
PCP was rare in B-cell precursor ALL patients receiving blinatumomab therapy, but is early onset and with rapid disease progression. Besides, PCP infection could not be ignored though prophylaxis has been given. Thus, more attention should be paid to when using blinatumomab therapy.
Impact of TKI Switching, Reduction, and Discontinuation on Cardiovascular Events in cml patients
Authors: Sato Nobue , Guo Yong-Mei , Nakamura Hirotaka , Uchiyama Satoshi , Kunisada Kodai , Chi Song-Gi , Nagata Akihito , Yamauchi Nobuhiko , Ogata Hiraku , Minami Yosuke , Yuda Junichiro
Published: November 2023

The development of tyrosine kinase inhibitors (TKIs) has dramatically improved the treatment outcomes of the chronic myelogenous leukemia-chronic phase (CML-CP). However, cardiovascular events (CVEs), such as hypertension, peripheral arterial occlusive disease, pulmonary arterial hypertension, and cerebral infarction, continue to occur, which highlights the need to develop preventive monitoring and treatment strategy for adverse vascular events. This study retrospectively analyzed the data on CVEs in 63 patients with chronic myeloid leukemia treated with TKIs at our institution. TKI treatments were discontinued in 1 patient and 16 patients owing to serious CVEs and adverse events other than CVEs, respectively. This study showed that male patients tended to experience more abnormal findings on cardiovascular examination and minor CVEs with increasing age than female patients. No prolongation of QT interval was observed. During follow-up, improvements in tricuspid regurgitant pressure gradient and brain natriuretic peptide values and hypertension were observed after reducing the dose of the same TKI, interrupting the TKI treatment, and switching from the second-and third-generation TKIs to imatinib (IM) or bosutinib (BOS). These data suggest the importance of CVE prevention via blood pressure control and cardiovascular examination in CML patients at high risk for CVE. Rapid intervention under the cooperation of a cardiologist is also essential when CVEs develop. The CVE risk may be decreased by switching to IM or BOS or via TKI dose reduction/interruption in patients in whom DMR is achieved. However, further studies with more patients are required.
Decoupled matrix Riccati differential equations approach for robust boundary data completion in time-fractional diffusion problems
Authors: J Fadhel , Mdim Ridha , Omri Haithem
Published: November 2023

This research introduces an innovative algorithmic framework tailored to solve the inverse boundary data completion problem for time-fractional diffusion equations in a bounded domain, especially under partially specified Neumann and Dirichlet conditions. This issue is notoriously ill-posed in the Hadamard sense which demands a sophisticated and nuanced approach. Our method innovatively transforms this problem into a system of first-order differential equations, linked with Matrix Riccati Differential Equations. Moving beyond traditional methods, our framework integrates a state-of-the-art decoupling algorithm, which effectively blends the strategic depth of optimal control theory with the precision of the Golden Section Search algorithm. This integration determines the optimal regularization parameter essential for ensuring the stability and the reliability of the solution. The robustness and effectiveness of our approach have been rigorously verified through extensive numerical experiments, proving its resilience even in conditions marked by significant noise levels.
AMS Subject Classifications: 34K20, 35Pxx, 35S16, 60K50, 35R11
Genomic correlation, shared loci, and causal relationship between insomnia and psoriasis: a large-scale genome-wide cross-trait analysis
Authors: Wang Qing , Wu Yuan , Wang Xuehua , Zhang Junhong , Su Haojie , Lu Yue , Wu Jingjing , Han Ling
Published: November 2023

Background
Psoriasis and insomnia have co-morbidities, however, their common genetic basis is still unclear.
Methods
We analyzed psoriasis and insomnia with summary statistics from genome-wide association studies. We first quantified overall genetic correlations, then ascertained multiple effector loci and expression-trait associations, and lastly, we analyzed the causal effects between psoriasis and insomnia.
Results
A prevalent genetic link between psoriasis and insomnia was found, four pleiotropic loci affecting psoriasis and insomnia were identified, and 154 genes were shared, indicating a genetic link between psoriasis and insomnia. Yet, there is no causal relationship between psoriasis and insomnia by two-sample Mendelian randomization.
Conclusions
We discovered a genetic connection between insomnia and psoriasis driven by biological pleiotropy and unrelated to causation. Cross-trait analysis indicates a common genetic basis for psoriasis and insomnia. The results of this study highlight the importance of sleep management in the pathogenesis of psoriasis.
Vinberg's T-algebras: From exceptional periodicity to black hole entropy
Authors: Marrani Alessio
Published: November 2023

We introduce the so-called Magic Star (MS) projection within the root lattice of finite-dimensional exceptional Lie algebras, and relate it to rank-3 simple and semi-simple Jordan algebras. By relying on the Bott periodicity of reality and conjugacy properties of spinor representations, we present the so-called Exceptional Periodicity (EP) algebras, which are finite-dimensional algebras, violating the Jacobi identity, and providing an alternative with respect to Kac-Moody infinite-dimensional Lie algebras. Remarkably, also EP algebras can be characterized in terms of a MS projection, exploiting special Vinberg T-algebras, a class of generalized Hermitian matrix algebras introduced by Vinberg in the ’60s within his theory of homogeneous convex cones. As physical applications, we highlight the role of the invariant norm of special Vinberg T-algebras in Maxwell-Einstein-scalar theories in 5 space-time dimensions, in which the Bekenstein-Hawking entropy of extremal black strings can be expressed in terms of the cubic polynomial norm of the T-algebras.
Segal's contractions, AdS and conformal groups
Authors: Sternheimer Daniel
Published: November 2023

Symmetries and their applications always played an important role in I.E. Segal’s work. I shall exemplify this, starting with his correct proof (at the Lie group level) of what physicists call the “O’Raifeartaigh theorem”, continuing with his incidental introduction in 1951 of the (1953) Inönü-Wigner contractions, of which the passage from AdS (SO(2,3)) to Poincaré is an important example, and with his interest in conformal groups in the latter part of last century. Since the 60s Flato and I had many fruitful interactions with him around these topics. In a last section I succintly relate these interests in symmetries with several of ours, especially elementary particles symmetries and deformation quantization, and with an ongoing program combining both.
SUCCESSFUL THERAPEUTIC MANAGEMENT OF DEMODICOSIS IN DOG
Authors:   Department of Teaching Veterinary Clinical Complex., A.A. Suryawanshi , R.V. Gaikawad ,   Department of Clinical Medicine, Ethics and Jurisprudence., C.N. Galdhar ,   Department of Clinical Medicine, Ethics and Jurisprudence., D.A. Pawalkar ,   Department of Veterinary Epidemiology and Preventive Medicine, Mumbai Veterinary College, Parel, Mumbai-400012.
Published: November 2023

A 5-month male Labrador dog weighing 10 kg was presented at Department of Teaching Veterinary Clinical Complex, Mumbai Veterinary College, Parel, Mumbai, Maharashtra.History of skin infection, continuous itching, alopecia, bleeding from wounds and hair fall. In addition, there was also a history of incomplete deworming and vaccination. Clinical examination revealed the presence of papules, crusts, exudates from lesions, hyper pigmentation, folliculitis and cellulitis.Upon skin scrapings and hair pluck examination, the mites of Demodex spp. were identified.The dog was treated with oral Sarolaner, Moxidectin, and Pyrantel pamoate(Simparica), cephalexin @ 30 mg per kg b.wt. and supportive therapy using immunostimulant, essential fatty acids,and topical chlorhexidine gluconate and miconazole shampoo. Dog showed complete recovery after 90 days of therapy.
OPTIMIZATION CONDITIONS OF RECYCLING WASTE PLASTIC PETON ASPHALT, BY USING APPLICATION OF RESPONSE SURFACE METHODOLOGY
Authors: Alaguid Ibrahim Sofo Hassan , Ahmed Mohammed Mohagir , Sidick Adam Batran , Ali Abakar
Published: November 2023

In this study, different conditions of waste plastic PET (Polyethylene Terephthalate) recycling on asphaltwereoptimized. Response Surface Methodology (RSM) using the Doehlert experimental design has been employed in the optimization. The independent variables considered were bitumen(5-8%), PET (0-12%), mixing temperature (150-160Â°C) and mixing time (20-30min). Four-second order polynomial models were generated. The responses obtained by the models were well described as: specificgravity (Y. SG), penetration (Y. P),softening point(Y. SP), and flash point (Y.FP) of the process with satisfactory fits in terms of absolute average deviation, bias factor and accuracy factor. The optimum responses were 1,05 g/cmÂ³ as specificity gravity (Y. SG), 60*(1/100mm)as penetration at 25Â°C, 100g and 5sec(Y. P), 50Â°C as softening point (Y. SP), and 244Â°C as flash point (Y. FP). The statistical relation between the four independent variables and the process responses was well described.