bluuebunny/crossref_metadata_2025 huggingface dataset:
Penguatan Rasa Kebangsaan: Identitas, Demokrasi, dan Kearifan Lokal dalam Undang-Undang Simbur Cahaya
Authors: Mu'jizah Mu'jizah
Published: April 2022

The political rifts and tensions after the 2014 elections cannot just disappear, they even penetrate to the grassroots and are increasingly felt to be able to shake the Indonesian nationality. Political rifts and tensions spread to social aspects and cause discomfort for people who want to live in peace. In fact, during the 76 years of Indonesia which was formed by the fathers of the Indonesian nation, it has proven its determination in building Indonesian unity. Therefore, we must study and reflect on how Indonesia builds its nationality through one of the texts entitled the Simbur Light Law. The text describes the strength of building identity, applying local wisdom values ​​in strengthening customs, and teaching democratic ways of life. The purpose of this research is to explore and find out how identity is built and the national values ​​that become the local wisdom of the Palembang people are held. The method used is a qualitative approach with analysis and interpretation of the text. From the results of the study, it was found that the people of Palembang have a strong and high sense of nationality. This sense of nationality is evidenced by a strong strong identity supported by firmness in holding on to customs, and building a high sense of solidarity with a democratic system that is adhered to together. The values ​​that become local wisdom are also applied in their social behavior. In conclusion, the text of the Undang-Undang Simbur Cahaya can be a reference for national life.

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Keretakan dan ketegangan politik setelah pemilu 2014 tidak dapat hilang begitu saja bahkan menyerap ke akar rumput dan semakin dirasa dapat menggoyah kebangsaan Indonesia. Keretakan dan ketegangan politik merambat ke aspek sosial dan menimbulkan rasa tidak nyaman bagi masyarakat yang ingin hidup damai. Padahal selama 76 tahun keindonesiaa yang dibentuk oleh para bapak bangsa Indonesia telah membuktikan keteguhanannya dalam membangun persatuan Indonesia. Oleh sebab itu, kita harus belajar dan merefleksi cara Indonesia membangun kebangsaan melalui salah satu naskah yang berjudul Undang-Undang Simbur Cahaya. Dalam naskah itu digambarkan kuatnya membangun identitas, menerapkan nilai-nilai kearifan lokal dalam memperkuat adat, dan pengajaran cara hidup berdemokrasi. Tujuan penelitian ini menelusuri dan menemukan bagaimana identitas dibangun dan nilai-nilai kebangsaan yang menjadi kearifan lokal masyarakat Palembang dipegang. Metode yang digunakan adalah pendekatan kualitatif dengan analisis dan interpretasi teks tersebut Dari hasil penelitian ditemukan bahwa masyarakat Palembang memiliki rasa kebangsaan kuat dan tinggi. Rasa kebangsaan itu dibuktikan dengan kuatnya identitas yang kuat didukung oleh keteguhan memegang adat, dan membangun rasa solidaritas yang tinggi dengan sistem demokrasi yang dipatuhi bersama. Nilai-nilai yang menjadi kearifan lokal juga diterapkan dalam perilaku sosialnya. Kesimpulannya naskah Undang-Undang Simbur Cahaya dapat menjadi rujukan untuk kehidupan berkebangsaan.
Potensi Hasil dan Keragaman Fenotipik Aren (Arenga pinnata (Wurmb) Merr.) Sulawesi Tenggara
Authors: Fatsan Ahmad , Sudarsono Sudarsono , Dinarti Diny , Maskromo Ismail
Published: April 2022

Aren adalah salah satu jenis palma yang penyebarannya sangat luas di Indonesia, termasuk di provinsi SulawesiTenggara. Pohon aren memiliki banyak manfaat mulai dari akar sampai daun. Bunga aren berbentuk mayang denganuntaian yang berlapis-lapis. Pengamatan fenotipik dan potensi nira aren dilakukan di tiga Kabupaten yaitu Muna, KolakaTimur dan Bombana.Pengamatan potensi aren Sulawesi Tenggara dilakukan dengan cara mengambil sampel 5 pohonaren di Kabupaten Muna, Kolaka Timur dan Bombana. Parameter karakter fenotipik meliputi lingkar batang dankomponen buah serta potensi poduksi. Hasil uji t-test pengamatan fenotipik aren Sulawesi Tenggara menunjukkanperbedaan yang signifikan pada karakter-karakter fase generatif, terutama aren Muna. Aren Bombana memiliki %brix20.6% lebih baik bila dibandingkan dengan aren Muna dan Kolaka Timur. Produksi rata-rata nira Muna lebih tinggidibandingkan kabupaten lainnya dengan rata-rata produksi23.64 l/mayang/hari sedangkan produksi rata-rata arenSulawesi Tenggara 20.65-23.64 l/mayang/hari.Kata kunci : Aren, Brix, Fenotipik, Generatif,Mayang, Nira
Pengaruh Biochar Kulit Buah Kakao dan Berbagai Agens Hayati Terhadap Pertumbuhan Bibit Kakao
Authors: Arham Arham , Bahrun Andi , Karimuna La , Rakian Tresjia Corina , Gusnawaty H.S. Gusnawaty H.S.
Published: April 2022

The use of cocoa pod husk biochar and various biological agents in the planting medium significantly increased the growth of cocoa seedlings. The research was conducted using a Randomized Block Design (RBD) with a Split Plot pattern.  The main factors consisted of 2 (two) treatment levels, namely: B0 (without biochar of cocoa pod skin) and B1 (15 g of cocoa pod husk biochar), while the child factors consisted of 4 (four) treatment levels, namely: A0 (without biological agents), M (arbuscular mycorrhiza 15 g), MR (arbuscular mycorrhizae 15 g + 15 ml rhizobacteria) and MT (arbuscular mycorrhizae 15 g + Trichoderma sp. 15 ml), so that there are 8 (eight) treatment combinations, namely: B0A0 (without biochar and without biological agents), B0M (without cocoa pod husk biochar + arbuscular mycorrhizae 15 g), B0MR (without cocoa pod husk biochar + arbuscular mycorrhizae 15 g + rhizobacteria 15 ml), B0MT (without cocoa pod husk biochar + arbuscular mycorrhiza 15 g + Trichoderma sp. 15 ml), B1A0 (cocoa pod husk biochar 15 g + without biological agents), B1M (cocoa pod husk biochar 15 g + arbuscular mycorrhizae 15 g), B1MR (cocoa pod husk biochar 15 g + arbuscular mycorrhizae 15 g + rhizobacteria 15 ml), B1MT (cocoa pod husk biochar 15 g + arbuscular mycorrhizae 15 g + Trichoderma sp. 15 ml), which repeated 4 (four) times so that there are 32 experimental units.  The variables observed were plant height, total leaf area, number of leaves, root length, root dry weight, shoot dry weight. The results showed that the interaction of cocoa pod husk biochar and biological agents had no significant effect on the growth of cocoa seedlings. Application of cocoa pod husk biochar 15 g/polybag had a significant effect in increasing the growth of cocoa seedlings compared to without cocoa pod husk biochar, while the application of biological agents was shown in the 15 g arbuscular mycorrhizae + Trichoderma sp. 15 ml / polybag has a very significant effect on increasing the growth of cocoa seedlings compared to without biological agents.Keywords:  Biochar, arbuscular  mycorrhizal, nutrient uptake.
Aplikasi Mulsa Daun Pisang dan Pupuk Organik Cair (POC) Bonggol Pisang terhadap Pertumbuhan Tanaman Cabai (Capsicum annum L.)
Authors: Nurmas Andi , Adawiyah Robiatul , Harjoni KW Laode Muh. , Rakian Tresjia Corina , Leomo Sitti , Nurhalimah Sitti
Published: April 2022

Rendahnya produktivitas tanaman cabai di Sulawesi Tenggara disebabkan kesuburan tanah yang rendah danketersediaan air yang terbatas akibat perubahan iklim terutama pada musim kemarau. Tanah-tanah di Sulawesi Tenggaradidominasi tanah marginal sehingga menjadi salah satu faktor penghambat pertumbuhan dan produksi tanaman. Salahsatu upaya yang dapat dilakukan dengan teknologi pemulsaan dan pemberian pupuk organik cair. Tujuan penelitianuntuk mengetahui pengaruh mulsa daun pisang dan POC bonggol pisang dalam meningkatkan pertumbuhan tanamancabai. Penelitian ini dilaksanakan di Laboratorium Lapangan Kebun Percobaan II Fakultas Pertanian UHO. yangberlangsung bulan Mei-Agustus 2019. Penelitian dilaksanakan menggunakan Rancangan Acak Kelompok (RAK) polafaktorial. Faktor I adalah mulsa daun pisang (M) terdiri atas 3 taraf yaitu kontrol (M0), Mulsa daun pisang 2 kg perpetak(M1) dan Mulsa daun pisang 4 kg perpetak (M2). Faktor II adalah POC bonggol pisang yang terdiri atas 3 taraf yaitukontrol (P0), POC 10 ml Lˉ1 air (P1) dan POC 20 ml Lˉ1 air (P1). Terdapat 9 kombinasi perlakuan dan masing-masingdiulang 3 kali sehingga diperoleh 27 unit percobaan. Variabel yang diamati yaitu tinggi tanaman, jumlah daun, jumlahcabang primer, jumlah cabang sekunder dan berat kering tanaman. Hasil penelitian menunjukkan bahwa perlakuan mulsadaun pisang dan pupuk organik cair (POC) bonggol pisang memberikan respon berbeda terhadap variabel pertumbuhantanaman cabai, baik secara mandiri maupun interaksi antar perlakuan.Kata Kunci: Mulsa Daun Pisang, Pupuk Organik Cair (POC) bonggol pisang, Tanaman Cabai
Evaluasi Perkembangan Penyakit Hawar Daun (Helminthosporium maydis) sebagai Penyakit Utama Tanaman Jagung Hibrida pada Tiga Sistim Pemupukan yang Berbeda
Authors: Basoka Sri Wahyuni , Khaeruni Andi , Taufik Muhammad
Published: April 2022

Penelitian ini bertujuan untuk mengevaluasi perkembangan penyakit hawar daun (Helminthosporium maydis) sebagai penyakit utama tanaman jagung hibrida pada tiga sistim pemupukan yang berbeda. Rancangan lingkungan yang digunakan adalah rancangan acak kelompok (RAK) dengan 3 perlakuan sistem pemupukan yang berbeda. Variabel yang diamati adalah keparahan penyakit (KP), Luas Daerah di Bawah Kurva Perkembangan Penyakit (LDBKPP) dan laju tumbuh relatif (LTR). Data hasil pengamatan dianalisis menggunakan metode analisis ragam dan dilanjutkan dengan uji jarak berganda Duncan jika perlakuan berpengaruh nyata pada α 0,05. Hasil penelitian ini menunjukkan Sistem pemupukan yang berbeda berpengaruh terhadap perkembangan penyakit hawar daun (Helminthosporium maydis) dan pertumbuhan tanaman jagung hibrida di lapangan. Sistem pemupukan yang mengkombinasikan 75% pupuk organik plus agens hayati Biofresh dengan 25% pupuk anorganik NPK dari dosis anjuran memberi respon terbaik terhadap ketahananan terhadap penyakit hawar daun dan pertumbuhan tanaman jagung hibrida di lapangan.Kata kunci: bahan organik, pupuk biofresh, pupuk kimia, penyakit hawar daun.
RITUAL KADIANO GHUSE PADA MASYARAKAT ETNIK MUNA DI KECAMATAN NAPABALANO KABUPATEN MUNA
Authors: Sunartin Sunartin , Niampe La , Ali Basri La Ode
Published: April 2022

Penelitian ini bertujuan : (1) untuk mendeskripsikan prosesi pelaksanaan ritual kadiano ghuse pada etnik Muna di Kecamatan Napabalano Kabupaten Muna; dan (2) untuk menganalisis makna simbolik yang terkandung dalam ritual kadiano ghuse pada masyarakat etnik Muna di Kecamatan Napabalano Kabupaten Muna. Teori yang digunakan sebagai alat analisis dan dasar pembahasan masalah dalam penelitian ini adalah teori interaksi simbolik  dan teori semiotika. Teknik pengumpulan data digunakan dengan cara: (1) observasi; (2) wawancara mendalam; dan (3) studi dokumen. Teknik analisis data dilakukan dengan cara: (1) penyusunan data; (2) sajian data; (3) penafsiran data; dan (4) penarikan kesimpulan. Berdasarkan hasil penelitian, ditemukan bahwa: (1) Prosesi pelaksanaan ritual kadiano ghuse  memiliki beberapa tahapan yang dilakukan, yaitu (a) pemanggilan pawang hujan; (b) menyiapkan bahan pelaksanaan ritual kadiano ghuse; (c) pawang hujan melaksanakan ritual  kadiano ghuse. (2) Bahan-bahan  yang digunakan  dalam ritual kadiano ghuse selalu memunculkan penggunaan simbol-simbol yang sangat sarat dengan makna tertentu, di antaranya (a)  Tabhako (Rokok) dan Bhakeno Saha (Buah Cabe) memiliki makna untuk mengarahkan hujan ke tempat lain dan menjadikan hujan menghindar dari tempat hajatan masyarakat; (2)  Paesa (Cermin), Ghohia (Garam) dan Winto Kontu ( Batu Asa) memiliki makna untuk menyinari langit agar cerah dan tidak turun hujan, dan sebagai media perantara doa air hujan tidak meluap di tempat hajatan masyarakat; dan (3) Roono Kalei  (Daun Pisang) dan Kalumembe (Tumbuhan yang dijadikan Sapu Tradisional) memiliki makna untuk mengeringkan awan di langit dan untuk menyapu bersih awan yang ada di langit. Kata kunci: Kadiano ghuse, prosesi, makna simbolik, etnik Muna
PENGENDALIAN KUALITAS PRODUKSI TEH TB 4 ASLI RCLT MENGGUNAKAN METODE SEVEN TOOLS PADA PT. XYZ
Authors: Prihandoko Danang , Fania Esta , Julita Jihan Nurul
Published: April 2022

PT. XYZ often experiences production constraints because of the tea TB 4 Asli RCLT's type of defective product during the production process. The purpose of this study is to find out the factors that cause the occurrence of defective products and provide recommendations that can be made to reduce the level of defective products. This study uses the Seven Tools method which consists of flow charts, check sheets, histograms, pareto diagrams, scatter diagrams, fish bone diagrams (cause-and-effect diagrams), and statistical process control (control charts). The results showed that there were 2 types of the biggest defects are Bag Overlap with a damage percentage of 26.15% and Tea in Seal 22.56%. These defects are caused by several major factors which are machines and men. The results of the study also show that the company's production process is still not well controlled. So, it is expected that PT. XYZ considers recommendations by giving more attention to the quality of the people who work and conducting in-depth analysis of other factors that can cause engine damage so that the company can reduce the level of defective products during the production process.
PENGARUH MEDIA SOSIAL INSTAGRAM TERHADAP KEPUTUSAN PEMBELIAN ONLINE MAHASISWI UNIVERSITAS HALU OLEO
Authors: Patwayati Patwayati , Nur Nofal , Mashud Olivia Anindyta
Published: April 2022

This study aims to determine the influence of Social Media Instagram Against Purchase Decision Management Online Student Halu Oleo University. The benefits of this research is to provide benefits theoretically can be useful as a contribution of thought to the world of education and is also expected to be a reference to further research and contribute thoughts, knowledge, images, and information will Influence Social Media Instagram Against Decision Purchase Online fashion products Student Management University Halu Oleo . The population in this study is a regular student class of 2015-2017 Department of Management Faculty of Economics, University of Halu Oleo. The data student active management majors we can see amounted to 708. The sample in this study was 88 female students using slovin method.The result of research stated that social media of instagram have a significant effect to online purchasing decision.
PENGARUH KARAKTERISTIK INDIVIDU, MOTIVASI KERJA, DAN MANAJEMEN PENGETAHUAN TERHADAP KINERJA PEGAWAI DINAS PEMBERDAYAAN MASYARAKAT DAN DESA PROVINSI SULAWESI TENGGARA
Authors: Rinjaya Doly , Nurwati Nurwati , Nasrul Nasrul , Sukotjo Endro , Palilati Alida , Madi Riski Amalia
Published: April 2022

This study aims to determine and analyze the effect of individual characteristics, work motivation and knowledge management on employee performance at the Office of Community Empowerment and Villages of Southeast Sulawesi Province. This research approach is quantitative. The population in this study was 77 employees of the Office of Community Empowerment and Village of Southeast Sulawesi Province, and all of them were made respondents. The data collected was analyzed using Partial Least Square (PLS) using the SmartPLS M3 2 program package.The analysis shows that individual characteristics have a positive and significant effect on performance, meaning that the better the individual characteristics of employees will improve performance. Work motivation has a positive and significant effect on performance, which shows that the better employee motivation will improve performance. Knowledge management has a positive and significant effect on performance, which shows that the better management of existing knowledge will improve employee performance.
PENGARUH DISIPLIN KERJA, SEMANGAT KERJA DAN KOMPENSASI TERHADAP KINERJA PEGAWAI PADA SEKRETARIAT DPRD KABUPATEN BUTON UTARA
Authors: Saputra Rizal Adi , Patwayati Patwayati , Sinarwati Sinarwati , Mokodompit Eliyanti Agus , Yusuf Abd. Razak , Kalimin La Ode , Isalman Isalman
Published: April 2022

This study aims to determine and analyze the effect of work discipline, spirit at work and compensation on employee performance in Secretariat of the Regional Representative Council of North Buton Regency. The research approach is quantitative. The population of this study was 35 employees of Secretariat of the Regional Representative Council of North Buton Regency. The number of samples used was 35 people with census techniques. The collected data was analyzed using Partial Least Square (PLS) using the SmartPLS M3 Ver. 2The results of the analysis show that work discipline has a positive and significant effect on employee performance with a parameter coefficient value of 0.282853, which means that the better work discipline then the resulting performance will be better. Spirit at work has a positive and significant influence on employee performance with a parameter coefficient of 0.293047, which means that the better the perceived spirit at work will have an impact on the resulting increase in performance. Compensation has a positive and significant effect on employee performance with a parameter coefficient of 0.400234, which means that the better the compensation given then will have an impact on the better performance produced.
PENGARUH CITRA SEKOLAH DAN PERSEPSI HARGA TERHADAP WORD OF MOUTH DAN KEPUTUSAN ORANG TUA MEMILIH SEKOLAH ANAK
Authors: Arifin Annisa Rahmawaty , Suwitho Suwitho , Djawoto Djawoto
Published: April 2022

This study discusses the direct influence of school image and price perception on word of mouth and the decision of parents to choose school children and the indirect effect of school image on parents' decision to choose school children through word of mouth as an intervening variable and the indirect effect of price perception on parents' decision to choose school children through word of mouth as an intervening variable. This research uses path analysis, F test, t test and sobel test. The sampling technique in this study is using the Slovin formula of 194 respondents from 3 school AL Azizi, Al-Amin and Aisyiyah schools in kelurahan Wage, kabupaten Sidoarjo. The results of this study indicate that the school's image has a positive and significant effect on the decision of parents to choose a child's school, the perception of price has a positive and significant effect on the decision of parents to choose a child's school, the school's image has a positive and significant effect on word of mouth, the price perception has a positive and significant effect on word of mouth, word of mouth has a positive and significant effect on the decision of parents to choose school children. In addition there is a significant mediating effect, word of mouth mediates the effect of the school's image on the decision to choose school and there is no mediating effect between the perception of price on the decision of parents to choose a child's school through word of mouth.
PERAN DISIPLIN KERJA DALAM MEMEDIASI PENGARUH PENGAWASAN DAN MOTIVASI KERJA TERHADAP KINERJA PEGAWAI LEMBAGA PEMBINAAN KHUSUS ANAK KELAS II KENDARI
Authors: La Mane Irwan , Syaifuddin Dedy Takdir , Nur Nofal , Bua Hasanuddin , Ansir Ansir , Saleh Salma
Published: April 2022

This study aims to analyze the effect of supervision, work motivation and work discipline on employee performance. To find out and analyze the effect of supervision and work motivation on work discipline, and see the mediating role of work discipline. This research was conducted at the Institute for Special Child Development Institution Class II Kendari. The population in this study amounted to 46 staff employees, sampling using census techniques with a total sample of 46 people. Research data were collected using a questionnaire and analyzed using Partial Least Square (PLS) analysis. The results of this study indicate that the higher level of supervision conducted will be able to improve work discipline and employee performance. Likewise, the higher work motivation of employees will lead to increased work discipline and employee performance. Work discipline plays a role in mediating the effect of supervision and work motivation on employee performance.This study aims to analyze the effect of supervision, work motivation and work discipline on employee performance. To find out and analyze the effect of supervision and work motivation on work discipline, and see the mediating role of work discipline. This research was conducted at the Institute for Special Child Development Institution Class II Kendari. The population in this study amounted to 46 staff employees, sampling using census techniques with a total sample of 46 people. Research data were collected using a questionnaire and analyzed using Partial Least Square (PLS) analysis.The results of this study indicate that the higher level of supervision conducted will be able to improve work discipline and employee performance. Likewise, the higher work motivation of employees will lead to increased work discipline and employee performance. Work discipline plays a role in mediating the effect of supervision and work motivation on employee performance.
PENGARUH KUALITAS LAYANAN DAN CITRA DESTINASI TERHADAP LOYALITAS DESTINASI
Authors: Rommy Nursaban
Published: April 2022

Service quality is a measure of the level of service provided in accordance with the expectations and expectations of tourists when visiting bokori island as a measure of the management of tourist attractions so that tourists feel satisfied and loyal. Destination image is a tourist's perception of a destination, which is related to the good name of a destination's significant and positive image of a destination, allowing tourists to make a repeat visit. Destination loyalty is the loyalty of tourists to a tourist attraction based on significant and positive perceptions so that tourists will make a repeat visit to a tourist attraction on the island of Bokori.The population for this study were all tourists visiting Bokori Island. Taking the number of samples in this study using the theory of rescoe. In this study there are 3 variables consisting of 2 independent variables (service quality and destination image) and 1 dependent variable (Destination loyalty), so the number of sample members taken for this study is 60 respondents. Researchers took respondents based on the coincidence encountered on the island of bokori and in accordance with the criteria of tourists visiting bokori island over 18 years and Kendari city tourists visiting bokori island more than 2 times. The results of this study indicate that service quality and destination image have a significant and positive influence on destination loyalty.
ANALISIS FAKTOR-FAKTOR MEMPENGARUHI STRUKTUR MODAL PADA PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BEI
Authors: Ruslan Ruslan
Published: April 2022

This study aims to determine whether profitability, sales growth, asset structure and liquidity affect the capital structure of manufacturing companies listed on the IDX in 2018. Data collection uses secondary data obtained from financial statements using purposive sampling techniques. The population is 170 manufacturing companies registered on the IDX in 2018, while the sample taken is 113. The results of the research variable data have been tested with the classic assumption test in the form of normality and heteroscedasticity tests. The method of data analysis uses multiple linear regression techniques. The results showed simultaneously that profitability, sales growth, asset structure and liquidity had a significant effect on capital structure. The results of the research partially showed that profitability and sales growth had no effect on capital structure. While the structure of assets and liquidity has a negative and significant effect on capital structure.
PERAN SPIRITUALITAS DITEMPAT KERJA SEBAGAI MEDIASI PENGARUH PENERAPAN KEPEMIMPINAN SPIRITUAL TERHADAP KINERJA PEGAWAI DI BALAI PEMASYARAKATAN KELAS II KENDARI
Authors: Wulandary Wulandary , Hatani La , Masri Muhammad , Ansir Ansir , Rommy Nursaban , Taufik Muhammad , Wati Enny
Published: April 2022

This research was conducted with the aim of examining and explaining the influence of spiritual leadership, workplace spirituality on employee performance and examining and explaining the role of spirituality in the workplace as a mediation for the influence of spiritual leadership on employee performance. This type of research is a quantitative approach with this type of explanatory research. The population in the study were all employees of the Kendari Class II Correctional Center, totaling 61 employees not including the leadership. The sampling technique was carried out by means of a census, meaning that the object of research was all the employees of the Kendari Class II Correctional Center. Analysis using structural equation modeling (SEM) using the SmartPLS version 3.2 program package. The results showed that spiritual leadership had a significant positive effect on employee performance. Spiritual leadership has a significant positive effect on spirituality in the workplace. Spirituality in the workplace has a significant positive effect on employee performance and Spirituality in the workplace plays a role in mediating the influence of spiritual leadership on employee performance.
PENGARUH KOMPENSASI, MOTIVASI DAN LINGKUNGAN KERJA TERHADAP KINERJA PERAWAT PADA RUS BAHTERAMAS PROVINSI SULAWESI TENGGARA
Authors: Handris Handris , Nurwati Nurwati , Mahrani Sri Wiyati , Saleh Salma , Tangalayuk Agustinus , Taufik Muhammad , Putera Asrip
Published: April 2022

The effect of compensation, motivation and work environment on the performance of nurses at Bahteramas Hospital, Southeast Sulawesi Province. This research was conducted with the aim of knowing and analyzing the effect of compensation, motivation and work environment on the performance of nurses at Bahteramas Hospital, Southeast Sulawesi Province. This research approach is a quantitative approach. The population of this study was 371 nurses at the Bahteramas Hospital, Southeast Sulawesi Province. The number of samples used in this study amounted to 79 nurses with the random sampling technique. The research model used multiple linear regression analysis with SPSS 20 software.The results showed that partially compensation has a positive and significant effect on performance; motivation has a positive and significant effect on performance. While the work environment has a positive but not significant effect on performance. Simultaneously compensation, motivation and work environment have a positive and significant effect on performance.
PENGARUH	KUALITAS JASA TERHADAP KEPUASAN PASIEN YANG DIMEDIASI OLEH CITRA RUMAH SAKIT (STUDI PADA PASIEN RAWAT INAP DI RUMAH SAKIT TIARA SENTOSA KENDARI)
Authors: Sabdar La Ode Man , Bua Hasanuddin , Yusuf Hayat , Syaifuddin Dedy Takdir , Sinarwaty Sinarwaty , Yusuf Abd. Razak
Published: April 2022

This study aims to: 1) examine the influence of service quality on hospital image, 2) examine the effect of service quality on patient satisfaction, 3) examine the influence of hospital image on patient satisfaction, 4) examine the effect of service quality on patient satisfaction mediated by hospital image. The type of this  research is explanatory research, then seen from the approach of research strategy or data collection process, this research uses survey method.  The population in this study was all patients treated at Tiara Sentosa Kendari Hospital. For sampling techniques researchers use non random or non probability selection in the form of purposive sampling. A total of 135 samples were obtained using the formula Hair et al (2010). Data is collected by interview methods and questionnaires. The analysis tool used is Partial Least Square (PLS). The results showed that both directly and indirectly, the quality of services has a positive and significant effect on patient satisfaction at Tiara Sentosa Kendari Hospital.
Blame Attribution, Partisanship, and Federalism: Evidence from a Panel Study
Authors: Uttermark Matthew , Mewhirter Jack , Sanders Rebecca , McLaughlin Danielle
Published: April 2022

When disaster strikes in federal systems, who do citizens blame and why? While several literatures posit that partisanship shapes patterns of blame attribution, the mechanism driving this relationship remains disputed. Specifically, whereas partisan blame attribution (PBA) suggests that partisans hold distinct preferences regarding which level of government should devise policies in times of crisis—and subsequently hold said level accountable when failure is observed—partisan federalism (PF) suggests that citizens opportunistically assign blame to the level of government controlled by their disfavored party. In this study, we examine the extent to which each theory explains patterns of blame attribution related to the ongoing COVID-19 pandemic. Leveraging panel survey-data collected before the 2020 election and after the 2021 transition, we find that Democrats follow PF expectations, whereas Republicans follow PBA expectations. Our findings indicate that scholars should revisit blame attribution and more carefully consider the role of federalism in determining citizen preferences.
Social Identity and Gubernatorial Approval: The Influence of Partisanship, Place Attachment, and Gender
Authors: Murphy Joseph , Griffin Bailey , Winburn Jonathan
Published: April 2022

In this paper, we focus on understanding what drives individual attitudes towards their governor. Using original surveys from March and May 2020, we test the role of social identities, namely partisanship, place, and gender, in explaining gubernatorial approval. We find that partisan congruence and state attachment are strong predictors of gubernatorial approval while gender congruence does not appear to influence gubernatorial approval.
Crowding out the Economy: Coronavirus and Governor Approval
Authors: Singer Matthew
Published: April 2022

Leaders are normally held accountable for economic outcomes. Yet accountability for the economy may weaken when other issues compete for the public’s attention. I posit that during the COVID-19 crisis, the public paid less attention to how leaders managed the economy and focused instead on how they managed the disease. I test this hypothesis using a time-series dataset of gubernatorial approval in 46 states based on 10,000 measures of governor popularity. While governor approval was strongly correlated with unemployment levels before COVID-19, governors were not punished for increasing unemployment during the crisis. Instead, governors were rewarded for enacting stringent policies early and then were held accountable for preventing COVID-19 deaths. Individual-level data shows, however, that Republicans diverged from the rest of the public and did not hold governors accountable for lockdown policies or for death rates. The results show the public’s issue agenda is not constant.
Tratamiento del Cáncer de Mama Metastásico, Receptor Hormonal Her 2 Negativo: Enfoque actual a Dianas Terapéuticas.
Authors: Valencia Espinoza Evelyn
Published: April 2022

En el cáncer de mama luminal, la terapia hormonal está indicada en adyuvancia y neoadyuvancia. El estadio metastásico incluye un grupo heterogéneo de tumores que varían de acuerdo con el sitio de metástasis, tiempo de aparición, condición general de las pacientes, entre otras características intrínsecas del tumor. Esto establece tiempos de sobrevida con rangos variables de meses a muchos años. Los estrógenos actúan en receptores de membrana citoplasmática y nuclear: en las células neoplásicas estimulan la transcripción del ARN, con persistencia de la proliferación. El bloqueo de la acción hormonal en el cáncer avanzado encuentra mecanismos de resistencia con el uso de vías de señalización paralelas, este conocimiento ha permitido el desarrollo de inhibidores de CDK 4/6, mTOR y PIK3-CA, que se recomiendan en enfermedad metastásica, con prolongación significativa de la supervivencia global. En crisis visceral aún se mantiene el uso de quimioterapia sistémica secuencial o combinada.
Investigating the Adipogenic Effects of Different Tissue-Derived Decellularized Matrices
Authors: Tang Weiya , Qi Jun , Wang Qian , Qu Yaping , Fu Su , Luan Jie
Published: April 2022

Objective: Decellularized adipose-derived matrix (DAM) can promote adipogenic differentiation and adipose tissue remodeling, but the biological impact of tissue origin on DAM remains unknown. The present study aimed to investigate the effects of tissue origins on the adipogenic capacity of the decellularized matrix by comparing the cellular and tissue responses of DAM versus acellular dermal matrix (ADM).

Methods: The in vitro response of adipose-derived stem/stromal cells (ADSCs) to DAM and ADM was characterized by proliferation and differentiation. The in vivo remodeling response was evaluated in the subcutaneous injection model of immunocompromised mice, using histology, protein expression, and transcriptome analysis.

Results: Both DAM and ADM exhibited excellent decellularization effects and cytocompatibility. In the absence of exogenous stimuli, DAM could induce adipogenic differentiation of ADSCs compared with ADM. In the animal model, the levels of PDGF, VEGF, and ACRP30 were higher in the DAM groups than in the ADM group, and more neovascularization and extensive adipose tissue remodeling were observed. The mRNA-seq analysis indicated that the DAM implant regulated tissue remodeling by modulating Lat1/2 expression along with Hippo Signaling pathway in the early stage.

Conclusion: Tissue origin can influence the biological response of the decellularized matrix. DAM can retain favorable tissue-specific characteristics after the decellularization process and have unique adipogenic effects in vitro and vivo, which can be fully utilized for soft tissue repair and regeneration.
Optimized Strengthening Based on Concrete Jacketing for Minimum Eccentricity
Authors: Mitropoulou Chara Ch. , Naziris Iordanis A. , Kallioras Nikos Ath. , Lagaros Nikos D.
Published: April 2022

The coupled lateral-torsional response is observed in building structures subjected to dynamic excitation due to lack of symmetry in terms of mass/stiffness in any of the stories’ plan views; such structural systems are called eccentric. Much damage and even collapse are concerned with building structures with asymmetric plan views. Combined torsional-translational vibration of their structural system results in higher ductility demands, especially to vertical structural elements located at the perimeter of the plan view. This study examines the minimization problem of the torsional response of an eccentric, multi-story reinforced concrete (RC) building by strengthening its vertical structural elements with RC jackets. The problem of minimizing the eccentricity between mass and rigidity centers for all story layouts and the corresponding minimization problem of the eccentricity between mass and strength centers for all stories are considered two separate formulations for the reduction of the torsional response optimization problem. Based on recent studies, the center of strength is preferable for assessing the torsional response of buildings in case of inelastic response. The imperialist competitive algorithm (ICA), a member of the family of evolutionary search algorithms, is used to solve the two optimization problems. The optimization problems are formulated for the case study building considered after assessing its structural behavior and capacity through nonlinear static analyses before and after strengthening. The later process was implemented to meet code requirements and examine the improvements achieved through optimization.
Recent Advances in Synthetic Methodologies to Form C-18F Bonds
Authors: Liu Zhiyi , Sun Yijun , Liu Tianfei
Published: April 2022

Positron emission tomography (PET) is an important technique for the early diagnosis of disease. Due to the specific physical and chemical properties of Fluorine-18, this important isotope is widely used in PET for labelling and molecular imaging, and its introduction into medicine molecules could produce PET tracers. Developing with the development of organic synthetic methodologies, the introduction of Fluorine-18 into drug molecules efficiently and rapidly under mild conditions, and the formation of C-18F chemical bonds, has become one of the leading topics in both organic synthetic chemistry and radiochemistry. In this mini-review, we review a series of recent advances in the organic synthesis of C-18F bonds (2015–2021), including non-catalytic radiofluorinations via good leaving functional groups, transition metal-catalyzed radiofluorinations, and photo- or electro-catalytic synthetic radiofluorinations. As a result of the remarkable advancements in this field, organic synthetic methods for forming C-18F bonds are expected to continue growing.
Antiviral and Virucidal Activities of Camptothecin on Fowl Adenovirus Serotype 4 by Blocking Virus Replication
Authors: Yin Dongdong , Yin Lei , Wang Jieru , Shen Xuehuai , Dai Yin , Zhao Ruihong , Hu Xiaomiao , Hou Hongyan , Zhang Danjun , Wang Guijun , Qi Kezong , Pan Xiaocheng
Published: April 2022

Fowl adenovirus serotype 4 (FAdV-4) caused hepatitis–hydropericardium syndrome in poultry and caused huge economic losses to the poultry industry. At present, antiviral drugs have not been reported to be effective against this virus, and new treatment methods are urgently needed to treat FAdV-4. Camptothecin has been shown to have antiviral activity against various viruses; however, whether it can inhibit FAdV-4 infection remains unclear. This study aimed to explore the anti-FAdV-4 effects and mechanisms of camptothecin in vitro and in vivo. Several camptothecin treatments were used to study the antiviral activity of camptothecin on FAdV-4-infected Leghorn male hepatocellular (LMH) cells. The FAdV-4 titers of mock and camptothecin-treated infected cell cultures were determined using tissue culture infective dose assay, and the FAdV-4 copy number was determined using quantitative real-time polymerase chain reaction. In addition, the therapeutic effect of camptothecin on FAdV-4-infected chickens was also evaluated. The results showed that camptothecin significantly reduced the viral replication in LMH cells in a dose-dependent manner, resulting in a reduction in viral titer, viral copy number, and viral Hexon protein expression. Camptothecin was also found to have a significant inhibitory effect on the viral replication step. Finally, camptothecin showed anti-FAdV-4 efficacy in the chicken infection model, and the survival rate was improved. This study was novel in proving that camptothecin had a protective effect against FAdV-4, indicating its potential as an antiviral drug against FAdV-4 infection.
SS31 Ameliorates Oxidative Stress via the Restoration of Autophagic Flux to Protect Aged Mice From Hind Limb Ischemia
Authors: Yang Qiaoyun , Li Chunqiu , Chen Qingwei
Published: April 2022

Background

Oxidative stress and impaired autophagic flux play important roles in the development of peripheral artery disease (PAD). SS31 is considered an important antioxidant peptide and autophagy regulator. We aimed to investigate the role of SS31 in PAD myopathy and its possible mechanism both in vivo and in vitro.

Methods

A hind limb ischemia (HLI) model was established with old C57BL/6 (14-month-old) mice. Mice in the SS31 group were intraperitoneally injected with SS31 (3 mg/kg) for 4 weeks. We examined skeletal muscle function and histomorphology, autophagy-related protein levels and reactive oxygen species (ROS) content. For the in vitro experiments, after C2C12 myotubes were treated with CoCl2, SS31, and chloroquine (CQ) or rapamycin (RAPA), we measured ROS content, autophagy-related protein levels and antioxidant enzyme expression.

Results

SS31 treatment effectively enhanced the recovery of skeletal muscle function, alleviated skeletal muscle injury and suppressed mitochondrial ROS production in ischemic limbs. SS31 reduced apoptosis and oxidative stress, and SS31 restored impaired autophagic flux by inhibiting the AKT-mTOR pathway. In vitro studies showed that SS31 restored autophagic flux and improved oxidative stress in C2C12 cells. Moreover, phosphorylated AKT (p-AKT) and phosphorylated mTOR (p-mTOR) levels were reduced.

Conclusion

These experiments indicated that SS31 can inhibit oxidative stress by restoring autophagic flux to reverse hypoxia-induced injury in vivo and in vitro.
Case Report: A First Case of Spontaneous Coronary Artery Dissection Potentially Associated With Scuba Diving
Authors: Mahendiran Thabo , Desgraz Benoît , Antiochos Panagiotis , Rubimbura Vladimir
Published: April 2022

Background

Scuba diving has rarely been associated with spontaneous arterial dissection. However, all documented cases have involved the cervicocranial arteries.

Case summary

We report the first case of spontaneous coronary artery dissection (SCAD) potentially associated with scuba diving in a 65-year-old female with no medical history or known cardiovascular risk factors. She presented with sudden-onset chest pain during her descent whilst scuba diving on holiday. An initial ECG revealed transient abnormalities, but due to normal initial blood tests, a reassuring echocardiogram, and the resolution of her symptoms, she was discharged from hospital without a clear diagnosis. During her subsequent presentation to our hospital 1 week later, electrocardiographic evidence of an inferior myocardial infarction (MI) was noted, with an echocardiogram revealing regional wall motion abnormalities of the left ventricular inferior wall. Coronary angiography revealed the presence of a SCAD of the posterior left ventricular artery, with cardiac magnetic resonance imaging confirming the presence of an inferior MI. As recommended in the majority of cases of SCAD, this case was managed conservatively with a favorable clinical course.

Conclusion

This is the first reported case of SCAD potentially associated with scuba diving. It highlights the importance of considering SCAD in patients presenting with sudden-onset chest pain during physical activity, especially in female patients (including older patients) with no cardiovascular risk factors. Furthermore, it serves as a reminder that symptoms during scuba diving are not always related to decompression illness.
Long-Term Outcomes After Implantation of Magnesium-Based Bioresorbable Scaffolds—Insights From an All-Comer Registry
Authors: Bossard Matthias , Madanchi Mehdi , Avdijaj Dardan , Attinger-Toller Adrian , Cioffi Giacomo Maria , Seiler Thomas , Tersalvi Gregorio , Kobza Richard , Schüpfer Guido , Cuculi Florim
Published: April 2022

Background

The magnesium-based sirolimus-eluting bioresorbable scaffold (Mg-BRS) Magmaris™ showed promising clinical outcomes, including low rates of both the target lesion failure (TLF) and scaffold thrombosis (ScT), in selected study patients. However, insights regarding long-term outcomes (>2 years) in all-comer populations remain scarce.

Methods

We analyzed data from a single-center registry, including patients with acute coronary syndrome (ACS) and chronic coronary syndrome (CCS), who had undergone percutaneous coronary intervention (PCI) using the Mg-BRS. The primary outcome comprised the device-oriented composite endpoint (DoCE) representing a hierarchical composite of cardiac death, ScT, target vessel myocardial infarction (TV-MI), and clinically driven target lesion revascularization (TLR) up to 5 years.

Results

In total, 84 patients [mean age 62 ± 11 years and 63 (75%) men] were treated with the Mg-BRS devices between June 2016 and March 2017. Overall, 101 lesions had successfully been treated with the Mg-BRS devices using 1.2 ± 0.4 devices per lesion. Pre- and postdilatation using dedicated devices had been performed in 101 (100%) and 98 (97%) of all the cases, respectively. After a median follow-up time of 62 (61–64) months, 14 (18%) patients had experienced DoCEs, whereas ScT was encountered in 4 (4.9%) patients [early ScTs (<30 days) in three cases and two fatal cases]. In 4 (29%) of DoCE cases, optical coherence tomography confirmed the Mg-BRS collapse and uncontrolled dismantling.

Conclusion

In contradiction to earlier studies, we encountered a relatively high rate of DoCEs in an all-comer cohort treated with the Mg-BRS. We even observed scaffold collapse and uncontrolled dismantling. This implicates that this metal-based BRS requires further investigation and may only be used in highly selected cases.
Higher Mortality Associated With New-Onset Atrial Fibrillation in Cancer Patients: A Systematic Review and Meta-Analysis
Authors: Murtaza Minha , Baig Mirza Mehmood Ali , Ahmed Jawad , Serbanoiu Liviu Ionut , Busnatu Stefan Sebastian
Published: April 2022

Aim

This research was conducted to evaluate the mortality outcome of cancer patients with new-onset atrial fibrillation. We also aimed to assess if there was any confounding relation between the mortality of these patients and surgical intervention.

Materials and Methods

A systemic search was conducted from electronic databases (PubMed/Medline, Cochrane Library, and Google Scholar) from inception to 7 February 2022. All statistical analyses were conducted in Review Manager 5.4.1. Studies meeting inclusion criteria were selected. Only those studies that involved cancer patients without pre-existing atrial fibrillation were selected, and mortality rate was compared between the patients who developed atrial fibrillation and those who did not. A random-effect model was used when heterogeneity was seen to pool the studies, and the result was reported in the odds ratio (OR) and the corresponding 95% confidence interval (CI).

Results

Eighteen studies were selected for meta-analysis. Statistical analysis showed that the cancer patients who subsequently developed atrial fibrillation had a significantly higher mortality rate as compared to those who did not (OR = 1.90 [1.65, 2.19]; p < 0.00001; I2 = 100%). We also separately analyzed the mortality risk in the surgery group and the non-surgery group. Statistical analysis showed that there was significantly higher mortality rate associated with new-onset atrial fibrillation in cancer patients in the surgery group (OR= 3.68 [2.29, 5.94]; p < 0.00001; I2 = 61%) as well as in the non-surgery group (OR = 1.64 [1.39, 1.93]; p < 0.00001; I2 = 100%).

Conclusion

Cancer patients, who subsequently developed atrial fibrillation, had a higher mortality rate as compared to those cancer patients who did not develop atrial fibrillation. A higher mortality rate was seen in both surgical and non-surgical subgroups. This implies that extra care and specific measures must be taken in the management of cancer patients with new-onset atrial fibrillation.