bluuebunny/crossref_metadata_2025 huggingface dataset:
Prevalence of cognitive impairment in Brazilian indigenous community from Amazonas
Authors: Carvalho Anna Paula de , Brucki Sonia Maria Dozzi , Nitrini Ricardo , Bezerra Camila Carlos , Silva Fernanda Carini da , Souza-Talarico Juliana Nery de
Published: August 2022

ABSTRACT. Studies on the prevalence of dementia in the indigenous population are still scarce worldwide. In the few available studies, prevalence evidence varies from low to very high, with early onset of the disease and high mortality rate after the initial diagnosis. Still, little is known about the rate of dementia in indigenous populations from low- and middle-income countries, where the dementia prevalence in the general population is estimated to increase significantly in the next decades. Objective: This study aimed to determine the prevalence of cognitive impairment and associated factors in Brazilian indigenous people of the Mura ethnicity in Amazonas, Brazil. Methods: A total of 217 indigenous individuals aged 50 years and older from Amazonas, Brazil, were submitted to cognitive assessment. Attention, memory, verbal fluency, visuospatial performance, and mood state composed the cognitive impairment diagnosis. Results: The prevalence of cognitive impairment was 43.3% (95%CI 36.6-49.7) and varied according to age [OR=1.03 (95%CI 1.00-1.06)], education [OR=0.74 (95%CI 0.62-0.87)], body mass index [OR=0.91 (95%CI 0.83-0.98)], and income [OR=0.52 (95%CI 0.27-0.99)]. Conclusions: Cognitive impairment had an early onset in an indigenous community, and its prevalence was greater in older individuals with low education and low family income. These findings highlight the importance of implementing public indigenous health policies focusing on health professional training for early cognitive impairment detection.
Registros rupestres na região central do estado de São Paulo: o Abrigo do Alvo, Analândia, São Paulo, Brasil
Authors: Amaral Marília Perazzo Valadares , Cisneiros Daniela , Araujo Astolfo Gomes de Mello
Published: August 2022

Resumo O Abrigo do Alvo, localizado no município de Analândia, São Paulo, apresenta registros rupestres, em sua maior parte compostos por gravuras, sobre substrato rochoso arenítico da Formação Botucatu. O abrigo foi originalmente registrado nos anos 1980 e, em 2012, novas intervenções foram realizadas no sítio, incluindo escavações e datações que inserem a ocupação mais antiga por volta de 7.500 anos cal AP. Neste artigo, apresenta-se uma análise detalhada dos registros rupestres localizados no Abrigo do Alvo, compostos majoritariamente por tridígitos, apresentando também linhas horizontais, linhas entrecruzadas, asteriscos, cúpules e figuras circulares. É abordado também o panorama geral do estado de conservação dos grafismos rupestres.
Prácticas mortuorias y manipulación de los cuerpos. Primer análisis tafonómico del sitio Los Tres Cerros 1 (Entre Ríos, Argentina)
Authors: Scabuzzo Clara , Raap María Agustina Ramos van , Lorenzo Bianca Micaela Di , Selan Daniela , Rios María del Pilar
Published: August 2022

Resumen El objetivo de este trabajo es profundizar en el conocimiento de las prácticas mortuorias llevadas a cabo en el sitio Los Tres Cerros 1 (Entre Ríos, Argentina), haciendo énfasis en los procesos vinculados con la manipulación intencional de los individuos. Para cumplir con este objetivo, se exponen los resultados del análisis de la preservación de los elementos óseos y del relevamiento de huellas antrópicas. El conjunto bioarqueológico está conformado por los elementos óseos correspondientes a un número mínimo de 35 individuos, enterrados en diversas modalidades de inhumación. Los resultados obtenidos de la aplicación de diferentes índices de preservación mostraron que hubo una perturbación antrópica homogénea del espacio mortuorio. Asimismo, el relevamiento de marcas antrópicas indicó la presencia de huellas de corte en el 6,68% de los elementos óseos analizados. Las mismas se registraron en todos los tipos de entierro y en los individuos de ambos sexos y distintos grupos etarios. Asimismo, la localización, la frecuencia y las acciones inferidas para cada uno de los entierros e individuos que integran las inhumaciones evidenciaron que existió variabilidad en la forma de manipulación de los cuerpos.
História e memória da pesquisa e acervo arqueológico da Usina Hidrelétrica de Balbina
Authors: Lopes Rhuan Carlos dos Santos , Santi Juliana Rossato , Silva Anna Barbara Cardoso da , Souza Taciane Silveira , Matos Amauri Assis , Veiga Wagner Fernando , Viana Guilherme
Published: August 2022

Resumo O artigo objetiva reconstruir a memória do acervo arqueológico da Usina Hidrelétrica de Balbina, situada no município de Presidente Figueiredo, estado do Amazonas. Para isso, abordamos aspectos ligados à Arqueologia amazônica e à construção de usinas geradoras de energia elétrica na década de 1980, bem como as políticas do licenciamento ambiental brasileiras. Partimos do debate sobre formação de acervos arqueológicos no Brasil tendo em vista o conceito de estratigrafia do abandono. A pesquisa foi realizada em instituições arquivísticas e através de entrevistas com profissionais ligados ao Projeto de Salvamento Arqueológico da UHE Balbina (SAUHEB). Com isso, apresentamos como ocorreu o processo de esquecimento de um conjunto de fontes arqueológicas, circunscritas no terreno das memórias exiladas, e ressignificadas a partir das ações patrimoniais contemporâneas.
Proposal for the Improvement of the Portal Transparency of the Executive Government of Santa Catarina
Authors: Ferreira Gilceu , Raupp Fabiano Maury
Published: August 2022

The purpose of this article is to provide guidelines for improving the data and public information transparency in the State of Santa Catarina, related to Education, through the Transparency Portal of the Executive Government. This is a descriptive and qualitative research, which uses an analysis model based on attributes of information quality. The population consisted of 61 information requests from 2019 based on the Access to InformationAct (LAI). Using a documentary and content analysis, the specific results that 88% of the requests refer to Basic Education and 12% to Higher Education. Another classification showed that 58.8% are associated with "Provision of Services", 29.4% in "Institutional Information" and 11.8% in "Financial Management". Twenty-three content proposals were elaborated addressing aspects of relevance, reliability, language, presentation, timeliness and historical series, which are part of the dimensions usefulness, understandability and temporality of the analysis model. The proposals deal with organizational information, human resources, schools, the state university, as well as services, actions and results, expenses and the agreements and transfers of resources related to Education. They address general aspects, such as the general number of students, teachers and schools, but they also guide the availability in a particular way, such as content related to certain expenses of each school. The creation of the “Education” thematic page on the Portal to concentrate the content repertoire and facilitate access and directing to other pages and existing features on the Portal, applying education filters, consisted of a general improvement proposal.
Factors that interfere with the behavioral intention of using remote classes by Accounting Sciences Course Students of Paraná State Public institutions
Authors: Goncalves Michele , Dos Anjos Edenise Aparecida , Costa Flaviano
Published: August 2022

The objective of this study is to verify the factors that interfere with the behavioral intention of using the classes in the remote modality by the Accounting Sciences Course Students of Paraná State Public Universities. The research was carried out through the quantitative approach and the structural equation modeling technique was used for data analysis (SEM). Technology Acceptance Model (TAM) was used as the basis, and the sample consisted of 292 respondents. The results of the study point out that the students perceived the usefulness and importance of the classes in remote modality using digital technologies, and that previous knowledge of technologies contributed positively to the ease of use perception. It was also possible to verify that the students found no difficulty accessing the classes in the environment provided by the IHE. Finally, despite all the challenges of the pandemic period and the emergency adoption of the remote classes modality, the Paraná State IHEs managed to continue with the school activities, overcoming great difficulties at a time of great uncertainty, and that the students understand that such changes were necessary, even if they didn't happen exactly as they would like to. The findings of this research are expected to contribute positively to the formulation of crisis coping strategies by the IHEs as well as to the planning of institutional virtual platforms.
Perfil epidemiológico de mulheres quilombolas submetidas ao exame citopatológico preventivo
Authors: Leite Renata Rose , Dos Santos Aliciene Mendes , Miranda Samilly Silva , Pimenta Rodolfo Macedo Cruz , Silva Marcus Vinícius Cardoso Matos , Vicentini Fernando , Passos Marcos Paulo Santos
Published: August 2022

Justificativa e Objetivos: As infecções do trato reprodutivo são consideradas uma importante demanda da saúde mulher, dada a sua alta prevalência na população e as consequências que podem causar, entre elas, o parto prematuro, infertilidade e câncer de colo de útero. Ainda há mulheres que não realizam o exame capaz de prevenir essas infecções, o exame citopatológico, seja por falta de orientação ou oportunidade, como as mulheres quilombolas. Este estudo teve por objetivo identificar fatores associados às infecções cérvico-vaginais em mulheres quilombolas de Feira de Santana, Bahia. Métodos: Estudo transversal, de caráter quantitativo e descritivo. As coletas foram realizadas no período de novembro de 2019 a janeiro de 2020, com aplicação do formulário de anamnese com as variáveis selecionadas. Foi realizada análise bivariada para analisar as razões de chance entre as infecções e as características encontradas. Resultados: Foram estudadas 82 mulheres, com idade média de 45,3 anos. As principais infecções vaginais foram causadas por: Gardnerella vaginalis (17,1%), Trichomonas vaginalis (8,5%), Cocos (8,5%), Cândida spp. (6,2%) e Fusobacterium spp. (1,2%). Conclusão: Os resultados obtidos neste estudo mostraram correlação entre o processo inflamatório nas mulheres e a presença de alguma infecção. No que diz respeito às infecções, houve maior prevalência em mulheres com escolaridade baixa, sem parceiro fixo e que não realizavam o exame preventivo regularmente.
KAMU YÖNETİMİNDE PARADİGMA DEĞİŞİMİ VE ORTAK ÜRETİM: FAHRİ TRAFİK MÜFETTİŞLİĞİ ÖRNEĞİ
Authors: DİLAVEROĞLU Arzu
Published: August 2022

Kamusal hizmetlerin sunumu ve içeriği, iç ve dış etkenlere bağlı olarak yenilenmekte ve çağa uyarlanmaktadır. Kamu yönetiminde reform, yeniden yapılanma, reorganizasyon, değişim gibi kavramlarla ifade edilen bu uyarlamadaki temel amaç mevcut yönetim anlayışının, daha etkin ve süreci verimli kılacak yapılarla değiştirilmesidir. Bu değişim sürecinde vatandaşın kamu hizmeti süreçlerine aktif katılımda bulunmasını öngören ortak üretim modeli, kamu yönetiminde üzerinde durulan konulardan biri olmuştur. Bu çalışmada ülkemizde uygulanan fahri trafik müfettişliği uygulamasının ortak üretim modeli açısından değerlendirilmesi amaçlanmaktadır. Bu amaç doğrultusunda; “Ortak üretim nedir? Hangi alanlarda ortak üretim yapılabilir? Ortak üretimin tipolojileri nelerdir? Ortak üretim yapılmasını sağlayan temel motivasyon kaynakları nelerdir?” şeklindeki sorular cevaplandırılarak ortak üretimin kuramsal çerçevesi çizilecektir. Betimleyici yöntem ve vaka analizinin kullanıldığı bu araştırmada, ortaya konulan kuramsal çerçevede fahri trafik müfettişliğinin kamuda ortak üretim sistemine uygunluğu, işleyişi, yapısı ve trafik güvenliğine katkısı analiz edilecek, ortak üretim konusundaki sınırlı Türkçe kamu yönetimi literatürüne katkı yapılmaya çalışılacaktır.
Self-deprecation: Searching for a Measure
Authors: Silva Santos Isabella Leandra , Pimentel Carlos Eduardo , Evangelista Mariano Tailson
Published: August 2022

Introducción: El autodesprecio es un constructo raramente estudiado por la psicología, generalmente considerado solo una faceta opuesta a la autoestima. Sin embargo, la literatura presenta su relación con la salud mental y el bienestar, lo que indica la relevancia de futuras investigaciones.

Objetivo: La presente investigación tuvo como objetivo desarrollar una medida de autodesprecio.

Método: Se realizaron dos estudios, ambos con 200 participantes brasileños (M = 21,73; DE = 5,87). Además del instrumento desarrollado, el segundo estudio utilizó la Escala de Autoestima de Rosenberg, la Escala de Autoestima de Ítem Único, la Escala de Narcisismo de Ítem Único y el Cuestionario de Agresión.

Resultados: Inicialmente, se realizó un análisis factorial exploratorio y un análisis de confiabilidad en el instrumento, que indicó una organización factorial única, explicando el 35 % de la varianza y obteniendo la confiabilidad de ω = 0,89. El segundo estudio buscó realizar análisis confirmatorios, análisis de calibración y correlaciones entre autodesprecio, autoestima, narcisismo y agresión. La escala presentó un buen índice de ajuste de ajuste (CFI = 0,97; TLI = 0,97; RMSEA = 0,04; y SRMR = 0,05). Hubo una correlación negativa entre la autoestima (r = -0,75) y la autodesprecio, así como positiva con todos los factores de agresión.

Conclusiones: la Escala de Autodesprecio mostró evidencia de validez y confiabilidad factorial. A pesar de ello, se destacan las limitaciones del estudio, en especial el uso del muestreo por conveniencia. Se concluye que se cumplieron los objetivos.
Insect cell expression of wildtype and variant LRRK1full length protein v1
Authors: Chatterjee Deep
Published: August 2022

The production of LRRK1 protein and its variants was performed using bacculovirus expression system. The method includes three major steps cloning, large scale expression and protein purification. The high quality LRRK1 protein produced through this method has been used for further biochemical and biophysical studies.
Ser intérprete indígena en Chaco (Argentina): implicancias de una categoría en construcción
Authors: Fraser Georgina
Published: August 2022

Esta comunicación se inscribe en una investigación en co-labor sobre los roles de los traductores-intérpretes en lenguas indígenas en el ámbito jurídico-judicial de la provincia del Chaco, Argentina. Allí se desarrolló un dispositivo para garantizar la presencia de traductores-intérpretes en lenguas indígenas en el ámbito de la justicia, que incluye formación, cargos y una coordinación entre los pueblos indígenas y el Poder Judicial. Orientadas a permitir el acceso de cierto grupo de personas a determinados recursos, estas medidas constituyen políticas de discriminación positiva. Entendiendo que las identidades son categorizaciones flexibles e interaccionales, nos interesa describir quiénes son los beneficiarios de este dispositivo y de qué manera la categoría de “indígena” incide en la decisión de unirse al Registro Especial de Traductores e Intérpretes de Lenguas Indígenas y los reclamos (o no) por la remuneración. El corpus está constituido por el registro audiovisual de talleres de interpretación y terminología para peritos traductores-intérpretes y estudiantes de las tecnicaturas en Interpretación en Lengua Indígena entre 2016 y 2019, entrevistas a traductores-intérpretes y actores del ámbito judicial, así como textos normativos. Nuestro marco teórico toma elementos de la teoría social, como los conceptos de aboriginalidad, fronteras simbólicas y sociales y extranjeridad, haciendo énfasis en el carácter procesual y flexible de las fronteras, y el carácter interaccional de la categorización. Entendemos que este trabajo puede aportar a la comprensión de las políticas de traducción para las lenguas originarias en América Latina, desde una mirada interdisciplinaria.
De la variación terminológica a la normalización: etapas metodológicas a partir de un corpus sobre conservación-restauración de bienes patrimoniales
Authors: Tebé Carles , Pissolato Luciana
Published: August 2022

En este artículo se aborda la constitución y explotación de un corpus textual monolingüe en español —variedad de Chile—, con el objeto de detectar y recolectar la variación terminológica extraída de los distintos géneros textuales que conforman el corpus. Este trabajo de investigación se enmarca en un proyecto —desarrollado entre la Pontificia Universidad Católica de Chile y el Centro de Conservación y Restauración de Chile— de normalización de la terminología de la conservación y restauración de bienes patrimoniales. Este es un ámbito de especialidad donde existe una amplia preocupación por la proliferación de variantes terminológicas de distinto tipo que dificultan la comunicación especializada entre los especialistas de esta área, y se ha observado y descrito tanto en español como en otras lenguas. El objetivo global del proyecto es recoger toda la variación terminológica existente en el corpus, llevar a cabo una descripción de los tipos y causas de esta variación, y constituir una base de datos terminológica que sirva de base para la etapa final de normalización de ese vocabulario. En este trabajo presentamos algunos resultados de la extracción terminológica del corpus, que nos permiten observar fenómenos interesantes de variación terminológica en el ámbito y que proporcionan información valiosa para las decisiones de normalización. En algunos casos, se pueden correlacionar distintas variantes según el género textual en el que se documentan.
El dativo genérico no te lo traduzco ni ahí
Authors: Oliver José , Berisso Gladys
Published: August 2022

Este trabajo tiene como objetivo mostrar estrategias para traducir construcciones de dativo genérico del español al inglés y, además, demostrar que la traducción automática no transmite el valor de este dativo. Para ello, analizamos tuits producidos por hablantes del español rioplatense que contienen construcciones de dativo genérico. Basamos nuestro análisis en la propuesta de que este dativo ocurre en construcciones que contienen marcas de genericidad/habitualidad e introduce argumentos no seleccionados por el verbo. Para el análisis de los datos, recurrimos a una metodología cualitativa y cuantitativa. A partir de un total de 54 casos, esbozamos una clasificación entre verbos inacusativos, de consumición y de movimiento, y observamos que la presencia del dativo genérico es más frecuente en algunos contextos sintácticos. Debido a la ausencia de un recurso equivalente en inglés, mostramos que las estrategias para traducir estas construcciones deben estar guiadas por la interacción entre estos contextos y el valor de genericidad/habitualidad del dativo genérico. Estos aspectos no se tienen en cuenta en las traducciones automáticas que ofrece Twitter. La dificultad que presentan estas construcciones plantea la necesidad de recurrir a un traductor humano que pueda interpretar lingüísticamente la polivalencia del dativo y reexpresarla mediante algún procedimiento translaticio que refleje la intencionalidad de la lengua origen en la lengua terminal. La relevancia de este trabajo radica en que es el análisis contrastivo el que puede arrojar luz sobre los recursos léxico-gramaticales que permiten codificar en inglés la información de genericidad/habitualidad del dativo genérico del español.
Machine Learning based Classification of Diseased Mango Leaves
Authors: Selvakumar A , Ananthakrishnan Balasundaram
Published: August 2022

The preponderance of population depends on agriculture to produce crops which would be their primary subsistence for their livelihood. So, agriculture is considered the backbone of any nation. Mango (Mangifera indica Linn), belonging to a family Anacardiaceous, is a conspicuous fruit that captivates all ages because of its meticulous taste, delicious flavor, ampleness variety, and highly lustiness. Mangoes are generally rich in minerals, vitamins, fibers, and negotiable fat. Mango plants are exposed to many micro-organisms. If these are not detected and treated in the initial developing stages, it would affect peculiar parts of the mango plant and result in loss of overall productivity. Several factors like biotic and abiotic always ensue in the decrease in the overall productivity of mango plants. Self-regulated Detection of mango plant disease is imperative, and it must be detected at the preliminary stages of the growing period of the mango plant. This paper discusses the existing methodology to classify diseases in mango plant leaves by implementing ensemble technique (Stack) which includes algorithms like Decision Tree (DT), Support vector machine (SVM), Neural Network (NN), and Logistic Regression (LR). The developmental results validate that the disease classification methodology can successfully classify a higher percentage in predicting whether mango plant leaf is healthy or diseased.
Investigations on PAPR and SER Performance Analysis of OFDMA and SCFDMA under Different Channels
Authors: L. N. Balai Girraj Kumar Jangid, Ashish Kumar Sharma,
Published: August 2022

Code Division Multiple Access (CDMA) and Orthogonal Frequency Division Multiplexing are two multicarrier regulatory systems that have improved due to the growing demand in quick communication (OFDM). A frequency division multiplexing (FDM) plot called orthogonal frequency division multiplexing is utilized as a sophisticated multi carrier regulation approach.

Due to its excellent spectrum efficiency and low data rate, the single carrier multiple access system (SC-FDMA) is a unique radio transmission technique that is now employed in long-term evolution (LTE) technology for uplink.  When compared to OFDM, reduced peak-to-average power ratio (PAPR) and error rate technique. PAPR performance has been obtained using Matlab simulation.  Techniques using variable numbers of subcarriers include SC-FDMA and OFDMA. Two various subcarrier assignment strategies have been proposed, distributed FDMA Localized FDMA and (DFDMA) (LFDMA). IFDMA, or interleaved FDMA, is a DFDMA special situation when DFT results have been distributed consistently and at the same distance. When comparing the SC-FDMA variants, we discover that Localized has a higher PAPR than interleaved (FDMA) (FDMA). We also talk about the Performance of LFDMA and IFDMA's SER (Symbol Error Rate) and found that localized (FDMA) performs better in the SER than interleaved (IFDMA) method.
Study of the effectiveness of interferon gamma therapy and evaluation of its effect on the level of cytokines in patients with chronic polypous rhinosinusitis
Authors: Baranova Nadezhda I. , Ashchina Lyudmila A. , Shkurova Natalia A. , Molotilov Boris A.
Published: August 2022

Background. Chronic polyposis rhinosinusitis is characterized by an immune-dependent type of polyp formation with a defect in local protective factors. The use of local immunomodulators will improve immune protection in the nasal cavity.
Aim. To study cytokine levels in nasal secretion and blood serum in patients with chronic polyposis rhinosinusitis after therapy with interferon gamma.
Material and methods. To study immunological indices, 32 patients with chronic polyposis rhinosinusitis, who were treated with intranasal interferon gamma, and 30 healthy people (control group) were examined. In the group of patients with the disease, the levels of interleukins-4, -10 and -18, tumor necrosis factor , and secretory immunoglobulin A were determined in the nasal secretion and blood serum before treatment and 1 month after it. Statistical analysis of the results was performed using the Statistica 12.0 software package. The test for normality of distribution in the sample was carried out using the ShapiroWilk test. Most of the parameters did not have a normal distribution; therefore, nonparametric statistical methods were used for further analysis. The description of the results obtained in the study was carried out by calculating the median (Me) and the interquantile range in the form of the 25th and 75th percentiles (Q0.25 and Q0.75). Comparative analysis of quantitative signs in independent groups was performed according to the MannWhitney test, in dependent groups using the Wilcoxon method. Differences were considered significant at p 0.05.
Results. Clinical efficacy was assessed according to a 4-point scale: excellent treatment result, good result, satisfactory and unsatisfactory. A good effect of the therapy was 78.1% (25 patients). Unsatisfactory effect was registered in 7 (21.9%) patients. After treatment, a decrease in the content of interleukin-4 (p2=0.000034), interleukin-18 (p2=0.000075), an increase in the level of interleukin-10 (p2=0.033), a decrease in the amount of secretory immunoglobulin A in the nasal secretion (p2=0.0001) took place. The levels of tumor necrosis factor in blood serum were reduced both before treatment compared with the control group (p1=0.005) and after therapy (p2=0.000075).
Conclusion. An increase in the content of interleukin-10 in the nasal secretion and a decrease in the level of proinflammatory cytokines interleukin-18, tumor necrosis factor and interleukin-4 in the blood serum after treatment with interferon gamma in patients with chronic polyposis rhinosinusitis may indicate a decrease in the activity of immune inflammation in the nasal cavity.
Evaluation of the results of neoadjuvant treatment in patients with HER2 positive breast cancer subtype
Authors: Kaganov Oleg I. , Orlova Anastasiya K. , Tkachev Maksim V.
Published: August 2022

Background. In women, breast cancer is the most common malignant tumor. Based on current clinical guidelines for HER2 positive tumor growth, it is possible to carry out preoperative chemotherapy for further organ-preserving operations. However, a prognostic scale for assessing neoadjuvant treatment has not yet been developed.
Aim. To create a mathematical model on the basis of which a computer program was developed to determine the likelihood of the neoadjuvant treatment effectiveness in patients diagnosed with HER2 positive breast cancer for further organ-preserving operations.
Material and methods. A planned retrospective study was performed at the Samara Regional Clinical Oncology Dispensary to assess the results of combined treatment of 93 patients diagnosed with breast cancer with HER2-positive tumor growth subtype with organ-preserving operations. The age of the patients was from 31 to 62 years, the mean age was 47.119.78 years. Three (15.53%) patients were diagnosed with stage I of the disease according to the TNM system, and 90 (84.47%) with stage II. A search for statistically significant predictors of achieving morphological regression as a result of preoperative chemotherapy was carried out.
Results. The mathematical model was created in the logistic regression module according to Wald's algorithm. Using SPSS 10.0, stepwise exclusion of predictors was performed. As a result of the multivariate analysis, a mathematical model and the corresponding program for the electronic computer Calculation of the achievement of complete morphological regression in patients diagnosed with primary operable breast cancer with epidermal growth factor receptors after neoadjuvant chemotherapy were created. In the future, the evaluation of the effectiveness of this program was compared with the results of 206 patients treatment.
Conclusion. The creation of a mathematical model and a computer program made it possible to personalize the most effective treatment regimen for patients diagnosed with HER2 positive breast cancer, depending on the initial characteristics of the tumor.
Variants of anomalies in the structure of the Willis circle in patients with acute cerebrovascular accident in various vascular beds
Authors: Perminova Svetlana K. , Yakupova Aida A.
Published: August 2022

Background. The frequency and severity of acute cerebrovascular accident depend on the variants of the anomaly in the structure of the Willis circle.
Aim. To identify the frequency and variants of the Willis circle anomaly in patients with acute cerebrovascular accident with an assessment of the severity of neurological disorders according to the National Institutes of Health Stroke Scale (NIHSS).
Material and methods. The study included 47 patients with acute cerebrovascular accident in conditions of the Willis circle anomaly: 21 male and 26 female, mean age was 67.0816.03 years. All patients underwent magnetic resonance imaging, magnetic resonance angiography of the brain, neurological examination using NIHSS.
Results. Patients with the absence of one posterior communicating artery had a significant stroke severity according to the NIHSS: 9.4295.840 points (moderate neurological disorders), p=0.016. The results in patients with the absence of both posterior communicating arteries were 5.6674.410 (p=0.939), in patients with posterior trifurcation 5.2006.058 (p=0.864), the group with an anomaly in the form of the absence of all communicating arteries had 4.0002.828 points (mild neurological disorders), p=0.602. The group of patients with anterior trifurcation showed the lowest results: 3.5002.121 points (p=0.492). Circulatory disorders in the posterior circulation system were significantly more common in the pathologies of the Willis circle consisting of trifurcation, and less common in other pathologies of the Willis circle, consisting in trifurcation, compared with the group of patients with the absence of at least one communicating artery (p=0.037).
Conclusion. Patients with stroke and the absence of one posterior communicating artery had neurological disorders of moderate severity according to the NIHSS, with the localization of the catastrophe mainly in the left middle cerebral artery circulation; in patients with the absence of both posterior communicating arteries, neurological disorders were of mild severity; patients with stroke in the posterior circulation system more often had an anomaly of the Willis circle in the form of a trifurcation.
The role of platelet microvesicles in the pathogenesis of preeclampsia
Authors: Galeeva Svetlana А. , Tadzhiboeva Nadzhiba А.
Published: August 2022

Among the diverse picture of preeclampsia, the hematological component, thrombocytopenia, attracts attention. Platelets are able to form microvesicles by budding the plasma membrane from the cell surface during apoptosis, stimulation, and also in a small amount in normal conditions. The membrane of these particles has a negative charge and contains phospholipids and an integral glycoprotein on the outer monolayer, due to which platelet microvesicles are involved in the process of blood coagulation and angiogenesis. Microvesicles are of platelet origin, they were first discovered in the middle of the last century in England when describing the phenomenon of plasma and serum coagulation in the absence of platelets in them. The number of platelet microvesicles dynamically changes during the formation of preeclampsia in pregnant women and in women with risk factors for the development of preeclampsia, which include obesity, arterial hypertension, diabetes mellitus, antiphospholipid syndrome. Exposure to these risk factors for preeclampsia before pregnancy leads to a change in the concentration of cells that produce microvesicles, which in turn can create conditions favorable for the development of preeclampsia during pregnancy. A special risk group are women with a history of preeclampsia. Taking into account the direct role of microvesicles in the processes of angiogenesis and blood coagulation, the study of these particles will allow a more detailed study of the pathophysiological aspects of the preeclampsia development, which will expand the possibilities for early prediction of this pathology and improvement of perinatal outcomes.
Creation of a regional register of children with latent tuberculosis infection
Authors: Slashcheva Daria M. , Brynza Natalya S. , Kicha Dmitry I. , Reshetnikova Yuliya S. , Petrushina Antonina D. , Pirogova Natalia D. , Tsvetkov Andrey I.
Published: August 2022

Background. In the context of the stabilization of the tuberculosis situation in Russia, including the Tyumen region, work with children at risk (with a latent tuberculosis infection) is of particular importance. In the course of previous studies, a number of problematic issues in the field of organizing phthisiatric care for this contingent were identified.
Aim. To substantiate and develop the structure of the regional register of children with latent tuberculosis infection, as well as the algorithm for collecting and registering information included in it.
Material and methods. The analysis of domestic and foreign publications, the current regulatory framework in the field of creation and use of registers in medicine and healthcare has been carried out. The study used content analysis, legal, historical and descriptive-analytical methods.
Results. The analysis of the literature showed that currently the practice of creating registers in medicine is particularly relevant, but there is no unified definition, classification, tasks and approaches to their management, therefore, the structure of the regional register of children with latent tuberculosis infection, the procedure for collecting and registering information were developed by the authors based on the functions inherent in it. The register is necessary for recording and monitoring of children with latent tuberculosis infection, optimization of medical processes, solving organizational and scientific issues in providing anti-tuberculosis care to this category of patients. The register consists of 8 blocks: identification, follow-up medical care, anamnesis vitae, epidemiological anamnesis, vaccination against tuberculosis, immunodiagnostics, radiation diagnostics, preventive treatment. The functions of filling in the blocks are distributed between the primary health care institutions and the phthisiological service, as well as assigned to certain specialists.
Conclusion. The developed data registration algorithm and the structure of the regional register of children with latent tuberculosis infection contain the data necessary for the implementation of the tasks set, operational and retrospective monitoring of the effectiveness of ongoing activities, as well as management decision-making at all levels of providing phthisiatric care to the children's population of the region.
Experience of simultaneous use of single-photon emission and X-ray computed tomography in cancer patients with fibrous dysplasia
Authors: Maksimova Natalia A. , Arzamastseva Marina A. , Agarkova Elena I. , Ilchenko Mariya G. , Engibaryan Marina A. , Pandova Olga V.
Published: August 2022

Aim to present the results of using single-photon emission computed tomography combined with X-ray computed tomography in the process of diagnosing osteodestructive changes in cancer patients with a rare comorbidity fibrous dysplasia. In the consultative and diagnostic department of the Federal State Budgetary Institution National Medical Research Center of Oncology of the Ministry of Health of Russia, Rostov-on-Don, in 2021, 2 patients with fibrous dysplasia of the skull bones and synchronous oncological diseases were examined. The patients underwent a complex of diagnostic tests: spiral X-ray computed tomography of the head, chest, abdominal cavity and small pelvis, bone scintigraphy, single-photon emission computed tomography combined with X-ray computed tomography of the skeleton bones, and puncture biopsy under ultrasound control. The described clinical observations clearly demonstrate examples of a phased diagnostic oncological search in patients without pathognomonic clinical manifestations and with multiple lesions of the skull bones. An increase in diagnostic information content in the differential diagnosis of fibrous dysplasia of the skeleton bones and bone metastases is facilitated by single-photon emission computed tomography combined with X-ray computed tomography. The combination of these two hybrid technologies provides an opportunity to simultaneous determination of the volume and localization of lesions, timely conduction of differential diagnostics and, in turn, maximum optimization of the examination and management of patients in this category.
Diversidad genética de Aedes aegypti en el eje transfronterizo Central-Alto Paraná en Paraguay
Authors: Britez Sady C. , Herrera Leidi , Ferreira María C. , Rolón Leticia M. , Ruiz Vanessa , González-Brítez Nilsa
Published: August 2022

Objetivos: Conocer la diversidad genética de Aedes aegypti en el corredor vial transfronterizo Central- Alto Paraná de Paraguay, con registros de casos de dengue. Materiales y métodos: Se seleccionaron veinte hembras adultas de la eclosión de huevos de Ae. aegypti procedentes de casas geolocalizadas en los departamentos de Alto Paraná, Caaguazú, Cordillera y Central, entre el 2018 y 2019. Se extrajo ADN del tejido de las hembras para amplificación aleatoria de sus patrones polimórficos mediante amplificación aleatoria del ADN polimórfico por PCR (RAPD-PCR), usando cebadores H3 y B03 a fin de conocer parámetros genéticos de diversidad poblacional. Las relaciones entre las poblaciones de mosquitos según la localidad fueron visualizadas mediante análisis no apareado de la media aritmética. Las áreas idóneas de distribución geográfica real y potencial de estas poblaciones de Ae. aegypti fueron analizadas mediante DIVA-GIS 7.3.0 y MAXENT. Resultados: Se identificaron 40 loci mediante perfiles RAPD-PCR, con diferenciación génica moderada (Gst = 0,12). El corredor transfronterizo presentó condiciones bioclimáticas para la presencia de poblaciones variantes de Ae. aegypti, siendo determinantes en la distribución la precipitación del trimestre más cálido y la temperatura media del trimestre más seco. Conclusiones: Se evidencia que existe diversidad genética moderada en las poblaciones de Ae. aegypti procedentes de zonas con registros de casos de dengue ubicadas en el corredor vial transfronterizo que une los departamentos Central y Alto Paraná de Paraguay. El estudio de variabilidad genética de Ae. aegypti es de gran utilidad para la vigilancia entomoepidemiológica y evaluación de posibles eventos de resistencia al control químico.
Precisiones sobre el artículo “Conocimientos, actitudes y percepción sobre el rol de los medios de comunicación respecto a la COVID-19 en estudiantes de Medicina de una universidad peruana”
Authors: Gonzales-Zamora José A.
Published: August 2022

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The effect of purple passion fruit juice on superoxide dismutase and malondialdehyde levels in hypercholesterolemic rats
Authors: Muntafiah Alfi , Siahaan Johanes Hasian , Hardi Sofyan , Novrial Dody , Hernayanti Hernayanti
Published: August 2022

BackgroundHypercholesterolemia due to a high cholesterol diet can increase free radicals resulting in oxidative stress. Superoxide dismutase (SOD) and malondialdehyde (MDA) have been used as the study markers of oxidative stress in cases of hypercholesterolemia. Purple passion fruit contains various compounds that may reduce free radicals. This study aimed to determine the effect of purple passion fruit juice on SOD and MDA levels in hypercholesterolemic rats.
MethodsAn experimental analysis with post-test only control group design involving 28 male Wistar rats. They were divided into 4 groups: normal control (K1), hypercholesterolemic control (K2), purple passion fruit juice treatment at 4.2 mL/200 gBW/day (K3), and simvastatin treatment at 0.018 mg/200 gBW/day (K4). The purple passion fruit juice at 4.2 mL/200 gBW/day was administered for 14 days. SOD levels were examined by enzymatic colorimetric methods using the Ransod kit and MDA levels by the TBARS method.
ResultsThe Kruskal-Wallis test showed a significant difference in SOD levels between the tested groups (p<0.05). One-way ANOVA test for MDA levels showed a significant difference (p<0.05). Post Hoc test (Mann-Whitney for SOD and LSD for MDA levels) also showed significant differences: K1 vs. K2, K2 vs. K3, K2 vs. K4, and K3 vs. K4 (p<0.05).
ConclusionThis study demonstrated that purple passion fruit juice significantly increases the SOD and lowers the MDA level in hypercholesterolemic male Wistar rats. Consumption of purple passion fruit juice may help to modulate oxidative stress caused by hypercholesterolemia in rats.
Diabetes mellitus patients in Indonesia: management in a tertiary hospital compared to primary health care
Authors: Permana Hikmat , Koesoemadinata Raspati Cundarani , Soetedjo Nanny Natalia Mulyani , Dewi Nury Fitria , Jayanti Novi , Imaculata Sofia , Ruslami Rovina , Alisjahbana Bachti , McAllister Susan Margaret
Published: August 2022

Background The increasing prevalence of diabetes mellitus (DM) requires that patients have greater access to care, which is yet lacking in many low- and middle-income countries and the quality of which varies between health care facilities. We compare the characteristics, complications, and risk profile of diabetes in patients receiving care in primary and tertiary level health facilities in Bandung, Indonesia.
MethodsAdult DM patients were recruited from 25 community health centres (CHCs) and the outpatient clinic at one referral hospital. Key data collected and compared to national guidelines were DM history, treatment, complications, blood pressure, height, weight, and laboratory examinations on glycated haemoglobin (HbA1c), lipid profile, and creatinine. Data analysis was by chi-square test.
ResultsOf the 809 DM patients (median age 59 years, 63% female, 98% type 2 DM), 318 (39%) were from CHCs and 491 (61%) from the hospital. Overall median HbA1c was 8.3%, with no difference between CHC and hospital patients. Only 32% of patients with HbA1c ≥10% were on insulin (CHCs 5.9%, hospital 42.9%), and only 18% of those on insulin had glycaemic control. Hypertension was common (CHCs 62%, hospital 51%, p<0.001), and only 44% of CHC and 34% of hospital patients received antihypertensive therapy. Among those with macrovascular complications, only 32% (CHCs) and 26% (hospital) were receiving aspirin. The numbers reaching the treatment targets were low for those on antihypertensives and lipid-lowering medications (80/251 and 11/105, respectively).
ConclusionGlycaemic control and management of complications of DM patients at both health care levels need considerable improvement.
Study of occurrence of risk factors of metabolic syndrome in women with PCOS
Authors: Bajpai Rashmi , Verma Priyanka , Gupta Monika
Published: August 2022

PCOS is one of the most common endocrine disorders of women in the reproductive age group. Metabolic syndrome is one of the major health issues currently to be focused on in young age group.

To identify women with PCOS at risk of developing the metabolic syndrome and the association of individual metabolic parameters with PCOS.

A prospective observational study done in 132 non pregnant women aged 18-35 years diagnosed with PCOS using Rotterdam’s criteria. Metabolic syndrome was diagnosed according to AHA/NHLBI (ATP III 2005) definition. Fisher’s exact test and unpaired t test were applied for statistical analysis.

Out of 132 women with PCOS, 31 met the criteria for Metabolic syndrome (23. 5%) and 69.7% women had at least one risk factor out of the five criteria of Metabolic syndrome. Among those meeting criteria for MBS, the mean waist circumference (≥80cms) and mean BMI was found higher (p0.01), and USGmorphology of PCOSp0.05) than those who did not. Presence of acanthosis, SBP/DBP(130/85mmHg), FBS(≥110mg/dl), TG(≥150mg/dl), HDL(≤50mg/dl) were found in significantly greater number in those who met the criteria for MBS as compared to those who did not.

Women diagnosed with PCOS and also having features of increased BMI, WC (≥88cms), acanthosis are important risk factors for association of PCOS with Metabolic syndrome in significantly higher numbers and it is important to initiate screening for the same.
Kekuasaan dan Politik Lembaga Pendidikan Islam
Authors: Aksan Rofik
Published: August 2022

The world of politics and power has become inseparable in policy making in all fields, this also happens in the world of Islamic education. Islamic Educational Institutions that are so widely spread throughout the country are of course a strategic issue in power and politics. The purpose of this article is to find out the extent to which Islamic education influences and influences power and politics in Indonesia. This article discusses several things about the political world in Islamic Education Institutions and discusses the relationship between power politics and Islamic education in Indonesia, the political urgency of Islamic education and the position of Islamic education in Indonesia. In addition, several issues will also be discussed including the Strength of Education, Politics and Power in Education, Islamic Education in Indonesia, Education Patterns in Indonesia, as well as four issues that are closely related to the implementation of power-based education, namely, domestication and ignorance, indoctrination, democracy education, and social integration.
Strategi Perubahan Budaya Organisasi dalam Meningkatkan Kecerdasan Emosional dan Spiritual Personal
Authors: Rahman Muhammad
Published: August 2022

This study aims to determine the strategy of organizational culture change to increase emotional and spiritual intelligence in organizational members. The method used is a qualitative approach with the type of library research (library research). Organizational culture change strategies include; aggressive approach, peaceful approach, corrosive approach and indoctrination approach. Then there are five stages of change, namely; deformative, reconciliative, acculturative, enactive and formative. Furthermore, the dimensions of change include; structural dimension, space and time dimension, change process dimension, contextual dimension and subjective dimension. The parameters are; expressive power, communality power, penetration power, adaptive power and endurance. Organizations that expect their organization's existence to be maintained must of course be friends with change. Organizational culture will certainly have an effect on organizational members, in this case it is hoped that the changes in organizational culture that are carried out can certainly be one of the foundations in increasing emotional and spiritual intelligence for every individual in the organization. The conclusion is that making a change to the organizational culture in order to improve the emotional and spiritual intelligence of members of the organization of course requires various strategies which must be adapted to each situation so that the desired results can be achieved.
Training Future Primary School Teachers for Purposes of the New Ukrainian School in the Postmodern Era
Authors: Koval Tetiana , Hryhorenko Viktoriia , Sebalo Liudmyla , Sevastiuk Mariana , Teletska Liudmyla , Yankovska Inna
Published: August 2022

The crisis of the outdated education system in Ukraine has led to radical changes at all levels. One of such vital changes in 2016 was the New Ukrainian School reform introduced by the Ministry of Education and Science of Ukraine. It relies on critical theories of the postmodern philosophy of education. They are as follows: toleration of difference, rejection of stereotypes and child-centeredness; transformation of teacher’s authority and roles; individualization of the educational process. Importantly, the New Ukrainian School reform has been launched in primary school as a fundamental part of the whole education system. In this regard, it is crucial to train primary school teachers of the new generation who will be able to implement the ideas of the New Ukrainian School. Consequently, it is extremely essential to update the system of corresponding training in higher education institutions in Ukraine. Therefore, the article aims to justify how future primary school teachers are trained for purposes of the New Ukrainian School in the postmodern era.