bluuebunny/crossref_metadata_2025 huggingface dataset:
Roxadustat Versus Epoetin Alfa for Treating Anemia in Patients with Chronic Kidney Disease on Dialysis: Results from the Randomized Phase 3 ROCKIES Study
Authors: Fishbane Steven , Pollock Carol A. , El-Shahawy Mohamed , Escudero Elizabeth T. , Rastogi Anjay , Van Bui Pham , Frison Lars , Houser Mark , Pola Maksym , Little Dustin J. , Guzman Nicolas , Pergola Pablo E.
Published: March 2022

Significance Statement

Iron supplementation and erythropoiesis-stimulating agents (ESAs) are currently recommended for treating anemia in patients with dialysis-dependent (DD)-CKD. However, safety concerns with ESAs have encouraged the development of alternative treatments for anemia. The phase 3 ROCKIES study is an international study of roxadustat, an oral hypoxia-inducible factor prolyl hydroxylase inhibitor, compared with epoetin alfa for the treatment of anemia of DD-CKD. Roxadustat was noninferior to epoetin alfa in increasing hemoglobin and reducing red blood cell transfusion, and reduced intravenous iron supplementation. Roxadustat was generally well tolerated and had an adverse event profile comparable to epoetin alfa. These results indicate that oral roxadustat is an effective alternative to parenteral ESA for the management of anemia in patients with DD-CKD.

Background

Concerns regarding cardiovascular safety with current treatments for anemia in patients with dialysis-dependent (DD)-CKD have encouraged the development of alternatives. Roxadustat, an oral hypoxia-inducible factor prolyl hydroxylase inhibitor, stimulates erythropoiesis by increasing endogenous erythropoietin and iron availability.

Methods

In this open-label phase 3 study, patients with DD-CKD and anemia were randomized 1:1 to oral roxadustat three times weekly or parenteral epoetin alfa per local clinic practice. Initial roxadustat dose depended on erythropoiesis-stimulating agent dose at screening for patients already on them and was weight-based for those not on them. The primary efficacy end point was mean hemoglobin change from baseline averaged over weeks 28‒52 for roxadustat versus epoetin alfa, regardless of rescue therapy use, tested for noninferiority (margin, −0.75 g/dl). Adverse events (AEs) were assessed.

Results

Among 2133 patients randomized (n=1068 roxadustat, n=1065 epoetin alfa), mean age was 54.0 years, and 89.1% and 10.8% were on hemodialysis and peritoneal dialysis, respectively. Mean (95% confidence interval) hemoglobin change from baseline was 0.77 (0.69 to 0.85) g/dl with roxadustat and 0.68 (0.60 to 0.76) g/dl with epoetin alfa, demonstrating noninferiority (least squares mean difference [95% CI], 0.09 [0.01 to 0.18]; P<0.001). The proportion of patients experiencing ≥1 AE and ≥1 serious AE was 85.0% and 57.6% with roxadustat and 84.5% and 57.5% with epoetin alfa, respectively.

Conclusions

Roxadustat effectively increased hemoglobin in patients with DD-CKD, with an AE profile comparable to epoetin alfa.

Clinical Trial registry name and registration number:

Safety and Efficacy Study of Roxadustat to Treat Anemia in Patients With Chronic Kidney Disease, on Dialysis. ClinicalTrials.gov Identifier: NCT02174731.
SARS-CoV-2-Specific T Cell Responses Are Not Associated with Protection against Reinfection in Hemodialysis Patients
Authors: Shankar Sushma , Beckett Joseph , Tipton Tom , Ogbe Ane , Kasanyinga Mwila , Dold Christina , Lumley Sheila , Dengu Fungai , Rompianesi Gianluca , Elgilani Faysal , Longet Stephanie , Deeks Alexandra , Payne Rebecca P. , Duncan Christopher J.A. , Richter Alex , de Silva Thushan I. , Turtle Lance , Bull Katherine , Barnardo Martin , Friend Peter J. , Dunachie Susanna J. , Hester Joanna , Issa Fadi , Barnes Eleanor , Carroll Miles W. , Klenerman Paul
Published: March 2022

Significance Statement

Patients on hemodialysis (HD) are vulnerable to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and mount poor neutralizing antibody responses after two-dose vaccination. Although serological responses have been associated with reduced rates of reinfection, the relationship between cellular immunogenicity and protection has not been established. We report, for the first time, high incidence of reinfection in patients on HD who are vaccine naive (25%), which identifies that T cell responses do not predict protection against reinfection. Instead, patients on HD who went on to become reinfected had mounted highly variable and sometimes robust proliferative T cell responses to a broad array of SARS-CoV-2 peptide pools during the primary infection. The understanding that SARS-CoV-2–specific T cell responses are not predictive of protection against future infection will be a critical issue when measuring clinical efficacy of vaccination in these vulnerable cohorts, particularly when facing rapidly emerging variants of concern.
Differential place marking beyond place names: Evidence from two Amazonian languages
Authors: Skilton Amalia Horan , Obert Karolin
Published: March 2022

Not all spatial adjuncts behave alike. In some languages, certain spatial adjuncts display different marking or different combinatorial possibilities than others. Recent functional-typological studies make two claims about this differential place marking phenomenon: (1) it is primarily motivated by noun semantics, opposing place names and other nouns; and (2) it is primarily realized as a contrast between zero-marking and overt marking of spatial adjunct function. We evaluate this view against new fieldwork data from two Indigenous Amazonian languages, Dâw (Naduhup) and Ticuna (isolate). In Dâw and Ticuna, differential place marking is conditioned not only by noun semantics, but also by the perceptual properties of noun referents and by morphosyntactic and semantic properties of verbs. Further, the phenomenon is realized not only by alternations between zero and overt marking, but also by alternations among overt markers and alternations in the set of markers with which the adjunct can combine. These findings suggest that differential place marking – like other differential case phenomena, such as split ergativity – is conditioned by a cross-linguistically diverse suite of factors within and beyond the noun phrase.
Associative-verbal network as a reflection of markers of the national identity of Sakha people
Authors: Vasileva Alina Petrovna
Published: March 2022

Abstract: The paper discusses the national culture Sakha language consciousness presented on the Yakut Associative dictionary, whose methodology was based on a mass associative experiment, resulted in an associative-verbal network, allowing not only a person's verbal memory fragment identification, but also a particular culture carriers of the world systemic image revelation. The author analyses the linguistically represented ​​northern ethnos culture traditional values through the prism of socio-cultural and linguistic processes determined by the globalized context. An attempt was made to identify the meanings that an ethnic group representatives put into certain traditional worldview key elements, national identity daily markers of the Sakha consciousness to understand their significant role in certain nation’s traditional national identity and culture formation and preservation.
 
Keywords: language consciousness; national identity and culture; associative-verbal network; worldview; lexicon.
Applied Psycholinguistics: A Science at the crossroads of cognition and language
Authors: Morais José
Published: March 2022

Abstract: Applied Psycholinguistics is a science that engages many others: experimental psychology, cognitive and neurocognitive sciences, linguistics, psychology of language and literacy, and educational and remediation sciences. The present paper’s objective is to show Science is itself a changing combination of ever-changing sciences without close boundaries, which implies the necessity of crossing domains in both research and learning. After a reminder of several topics of relevance to applied psycholinguistics, which concern mental processing, how cognition relates to the brain and to language, and how cognition and language engendered literacy, I argue that research in the corresponding sciences needs to be opened to other dimensions, such as society, culture, and politics. Finally, I evoke the history of the ideas regarding the isolationism of individualized sciences vs. their unification, taking, as examples of the latter, the early Marxism, and the International Movement for the Unity of Science from the fourth decade of the 20th century.
 
Keywords: Applied Psycholinguistics; literacy as product of cognition and language; concept of Science; history of scientific ideas; permeability of science to culture and politics.
On Algebra, Cosmic Triangles and the shape of our Universe
Authors: S Kalimuthu
Published: March 2022

The curvature parameter k and the density parameter omega play the dominant phenomena determining the fate of our universe. According to these two scales, the geometry of the universe has three possibilities namely, flat, open, or closed. The flat and open universe will have continual expansion. But the closed universe will turn around and collapse. If k is zero, the universe is flat, if it is greater than zero, it is closed and if k is less than zero the universe will be open. And if the density parameter Omega is one (1), the universe is flat, if it is greater than one, the universe will be closed and if it is less than one, the universe is open. The main thing is that if the sum of the interior angles of the cosmic triangles is equal to 180 degrees, the geometry of our universe is flat /Euclidean If it is less than 180 degrees, the shape of our universe is open/ hyperbolic and if it is greater than 180 degrees it is closed/elliptic. In this short work, by applying the fundamental operations of classical algebra to the cosmic triangles, the author attempts to prove that the shape of our universe is flat.
[RETRACTED] Natures Only CBD Gummies Review (Scam or Legit) Worth Buying? Update 2022 v1
Authors: Only CBD Gummies Natures
Published: March 2022

[RETRACTED]

In today`s unexpectedly converting environment, respiration comfortably, relaxing, and unwinding has end up extra complex. Because in their stressful jobs and demanding schedules, many humans international consume poorly. As a end result of those dangerous routines, their general fitness suffers. It's similarly critical to appearance after one's intellectual fitness. Psychological wellbeing is likewise an important aspect of bodily wellbeing as it permits humans to reply correctly to diverse conditions and circumstances.
Shipping wastewater samples to FDA-CFSAN v1
Authors: Balkey Maria
Published: March 2022

This SOP provides guidance for shipping wastewater samples to the US FDA Center for Food Safety and Applied Nutrition (CFSAN), covering specific steps for registering samples with CFSAN and for the preparation of shipments (documentation, packaging, notifications). We recommend that samples are shipped in two batches, one batch after 3 months of sampling and one batch at the conclusion of your sampling (~6 months).
SCA-seq v1
Authors: Tang Chong
Published: April 2022

methylation，cut and ligation
[RETRACTED] Derma Progenix Skin v1
Authors: not provided getdermaprogenix
Published: March 2022

[RETRACTED]

Now you don’t have to run here and there to get your skin surgery done to reduce aging affects, when you have Derma Progenix Skin. It is a perfect and natural anti aging cream that will give you fresher and glowing skin tone in few days of applying it regularly.
Modified NEBNext® VarSkip Short SARS-CoV-2 Library Prep Kit for Illumina Platforms - adapted for wastewater samples v2
Authors: Ramachandran Padmini , Walsky Tamara , Windsor Amanda , Hoffmann Maria , Grim Chris
Published: March 2022

PURPOSE: This method was developed at the FDA’s Center for Food Safety and Applied Nutrition for GenomeTrakr’s pandemic response project, monitoring SARS-CoV-2 variants in wastewater. Protocols developed for this project cover wastewater collection, concentration, RNA extraction, RT-qPCR, library prep, genome sequencing, quality control checks, and data submission to NCBI. This modified protocol details methods for cDNA synthesis and library preparation for sequencing of wastewater samples containing SARS-CoV-2. The protocol is based primarily on the NEBNext® ARTIC SARS-CoV-2 Library Prep Kit (Illumina®), NEB #E7650S/L 24/96 reactions, with a few modifications. Primarily, VarSkip Short primers are used in place of the ARTIC V3 primers. These primers are available in the NEBNext®ARTIC SARS-CoV-2 FS Library Prep Kit (Illumina®); however, for optimal variant detection from wastewater, sequenced fragments should be as large as possible, so we discourage fragmentation prior to end prep. There are a couple of decision points in this protocol. Examining cDNA amplicon samples on an Agilent TapeStation system or similar fragment analyzer is extremely helpful in making these decisions. Version Updates: V3- Controlled vocabulary for positiveControl and negativeControl has been added to the Sample Sheet.
P2 sharing is enable v1
Authors: not provided maria
Published: March 2022

test
Screening whole proteome of Aedes aegypti and identification of potential targets for in-silico molecular and structural interaction studies against natural bioactives v1
Authors: S Setlur Anagha , K Chandrashekar , Sarkar Manas , Niranjan Vidya
Published: April 2022

As a dangerous etiological agent for dengue, chikungunya, zika and yellow fever, it is essential to combat the incidences of Aedes aegypti, by using repellents. However, chronic overuse of synthetic repellents has led to possibilities of adverse side effects in humans. As a consequence, scientists and researchers are now shifting the focus of research on developing natural alternatives to these repellents. In such a case, the present study aimed to devise a standard protocol that can screen the whole proteome of A. aegypti and identify the major proteins that can be targeted by natural bioactives to produce repellents. To study the binding of the natural actives and the targets, a whole proteome analysis was carried out by finding the reference proteome of the organism, performing a literature survey to identify the potential targets, understanding the circadian rhythm of A. aegypti to identify the proteins expressed in the dark and light cycles, and shortlisting the targets by analyzing the common conserved domains of query sequences. Twenty protein target categories were identified, out of which 309 protein sequences were modelled using standalone tool- RaptorX. These structures were validated using Ramachandran plots from SAVES v6.0. Molecular docking studies using POAP, between the selected representative of the twenty protein targets and the natural bioactives revealed negative binding energies. Those that had the least negative energies were taken forward for 100ns molecular dynamic simulation studies, from which the docked complex stabilities were noted and the conformational changes induced during simulations were revealed. This protocol allows whole proteome analysis that will enable identification of major protein targets that the naturals can act upon, and further reveals the effectiveness of the use of naturals against these proteins, thereby, implying the use of this methodology for whole proteome analysis of other organisms as well. Keywords: Whole proteome, Aedes aegypti, conserved domains, homology modelling, docking, molecular dynamic simulations
Web 2.0 Uygulamalarının Öğrencilerin Fene ve Teknoloji Kullanımına Yönelik Tutumlarına Etkisi
Authors: AKBABA Koray , ERTAŞ KILIÇ Hülya
Published: March 2022

Bu çalışmanın amacı; fen bilimleri dersinin teknoloji destekli olarak yürütülmesinin ve gerçekleştirilen Web 2.0 uygulamalarının ortaokul 6. sınıf öğrencilerinin fene ve teknolojiye yönelik tutumlarına etkisini ortaya koymaktır. Gerçekleştirilen çalışmada nicel araştırma yöntemlerinden ön test-son test kontrol gruplu yarı deneysel desen kullanılmıştır. Çalışma grubunu, Kars ilinin Merkez ilçesinde yer alan bir yatılı bölge ortaokulunun 6. sınıf öğrencileri oluşturmaktadır. Çalışma grubu oluşturulurken uygun örnekleme yöntemi kullanılmıştır. Toplam 48 (24 deney, 24 kontrol) öğrencinin katıldığı çalışma, 6. sınıf fen bilimleri dersinin “Işık ve Ses” ünitesi ile “Bitki ve Hayvanlarda Üreme Büyüme ve Gelişme” üniteleri kapsamında gerçekleştirilmiştir. Uygulama, “Işık ve Ses” ünitesi için 3 hafta (12 ders saati), “Bitki ve Hayvanlarda Üreme, Büyüme ve Gelişme” ünitesi için ise 4 hafta (16 ders saati) olmak üzere toplam 7 hafta (28 ders saati) sürmüştür. Veri toplama aracı olarak, araştırmaya katılan öğrencilerin fen bilimleri dersine yönelik tutumlarını belirlemek amacı ile “Fene Yönelik Tutum Ölçeği”, teknoloji kullanımına yönelik tutumlarını belirlemek amacıyla “Teknoloji Kullanımına Yönelik Tutum Ölçeği” kullanılmıştır. Araştırmadan elde edilen bulgular neticesinde, Web 2.0 uygulamaları ile yürütülen fen öğretiminin öğrencilerin derse ve teknoloji kullanımına yönelik tutumlarını olumlu etkilediği tespit edilmiştir.
Politicians and Racism on Twitter: Citizen Reactions and New Forms of Social Participation
Authors: Olmos Alcaraz Antonia
Published: April 2022

This paper is a study case that analyses the various functioning logics of racism and anti-racism in Twitter, specifically following the publication of a polemic tweet against immigration by Pablo Casado, president of PP, which aligns itself on the conservative “right” of Spanish politics. The aim is to provide knowledge –still scarce in research on the subject– on the characteristics of racist discourse –and its confrontation– in digital spaces. It is a case study analysing how the selected political discourse, as elite discourse, elicits reactions and provokes social participation in digital spaces. Methodologically, it is based on Twitter content analysis, utilizing both quantitative (frequency of topics) and qualitative (articulation of arguments) approaches. We worked through the NVivo analysis software and selected a sample of tweets, that were then coded and analysed in depth, responding to the politician’s overall message. The results point to the existence of a strong rejection to the politician's words. However, there was an absence of a visibly explicit and significant anti-racism in the ensuing retorts. The support received for his racist comment was in the minority, although some were very aggressive.
Drivers and Barriers of Digital Market Integration in East Africa: A Case Study of Rwanda and Tanzania
Authors: Arnold Stephanie
Published: April 2022

Digital development has become a firm pillar in the national development strategies of many countries in the Global South. Although the geopolitical competition over ICTs leveraged their diplomatic and economic relevance in the international sphere, developing countries remain in a subordinate position in global power relations. However, while they could collectively improve their standing by uniting behind an integrated digital market, national governments in the East African Community are reluctant to implement a single digital market, leading us to inquire: What constrains digital market integration in East Africa? This article compares Rwanda and Tanzania, two relatively digitally mature but less developed countries in Sub-Saharan Africa, whereas one is a small landlocked country and the other a larger emerging economy. Following the classification of Hout and Salih, material, ideational, political, and external aspects affect a nation’s enthusiasm for regional initiatives. By examining factors related to domestic politics and political economy, this article finds that material and political factors encourage digital regionalism in Rwanda but discourage it in Tanzania; ideational factors contribute to national rather than regional unity in both countries. Yet, external factors linked to EU foreign policy and developmental cooperation seem to lead current regional projects. Therefore, this article concludes that drivers of African regionalism may turn into barriers depending on the domestic political and economic circumstances while digital market integration is currently driven by foreign players. More generally, the study contributes to the debate on African agency in ICT for development and developing countries’ capacity to overcome traditional dependency structures.
Rapid Estimation of Seismic Intensities Using a New Algorithm That Incorporates Array Technologies and Ground-Motion Prediction Equations (GMPEs)
Authors: Chen Wenkai , Wang Dun , Si Hongjun , Zhang Can
Published: March 2022

Rapid seismic intensity maps for damaging earthquakes enable the swift implementation of earthquake disaster mitigation action, issuance of accurate tsunami warnings, and prevention of associated secondary disasters. However, many countries lack dense local seismic observation networks, making it infeasible to obtain accurate seismic intensity maps of earthquakes within a few hours, particularly for earthquakes that have considerable source extents. In this study, we developed a new algorithm for rapidly obtaining seismic intensity maps of damaging earthquakes. With our model, source energy radiation is acquired using backprojection, and then the locations and relative amplitudes of the fault geometry and subevents are determined. Peak ground accelerations and peak ground velocities (PGVs) are subsequently calculated based on ground-motion prediction equations and the distribution of the estimated subevents. PGVs are then further site-corrected using the VS30 database (Wald and Allen, 2007; Heath et al., 2020). The algorithm was applied to the 2008 Mw 7.9 Wenchuan and 2010 Mw 6.9 Yushu earthquakes, and the resulting seismic intensity maps were highly similar to those generated by field surveys. The algorithm is simple and straightforward to use, and local real-time instrument observations are not required. Calculations can be performed automatically, and reliable seismic intensity maps can be issued within 30 min following damaging earthquakes. The model’s application may assist greatly with rescue and recovery efforts, and enable tsunami hazards to be evaluated immediately following earthquakes, particularly in regions lacking dense observation networks.
Análise dos conectores “com o objetivo de” e “com o intuito de” à luz da Linguística Funcional Centrada no Uso
Authors: Do Rosário Ivo da Costa , Souza Brenda da Silva
Published: March 2022

Sob o escopo teórico-metodológico da Linguística Funcional Centrada no Uso, o presente trabalho objetiva analisar as principais propriedades morfossintáticas e semântico-pragmáticas das microconstruções conectoras com o objetivo de e com o intuito de. A coleta de dados foi realizada nos corpora de modalidade escrita do português brasileiro contemporâneo, organizados pelo Núcleo de Pesquisa em Abordagem Construcional da Gramática e Tradução (NUPACT), da Universidade Federal de Juiz de Fora (UFJF). Por meio de uma análise prioritariamente qualitativa, os resultados indicam que, apesar de não estarem previstas nas principais gramáticas tradicionais, ambas as microconstruções atuam como conectores que veiculam a noção de finalidade em orações não finitas. Nessas orações, por sua vez, a posição dos conectores implica diferentes valores discursivo-pragmáticos. As microconstruções com o objetivo de e com o intuito de são formadas a partir dos processos de neoanálise e de analogização (TRAUGOTT; TROUSDALE, 2013). Além disso, os dados investigados revelam que ambas podem ser consideradas aloconstruções, já que são atestadas em um quadro de variação construcional (cf. PEREK, 2015).
estudo de construções com o verbo deixar em fala espontânea do português brasileiro
Authors: Lima e Silva Luis Filipe , Costa José Carlos , Coelho Sueli Maria
Published: March 2022

Este trabalho analisa o comportamento do verbo deixar no português brasileiro utilizando dados de fala espontânea extraídos do corpus C-ORAL-BRASIL I (RASO; MELLO, 2012). Em vista da multifuncionalidade desse verbo, relatada em outros estudos (cf. TRAVAGLIA, 2017[2007]; PINTO, 2008), procurou-se observar suas ocorrências, de modo a verificar se sua distribuição, na fala espontânea, é equivalente àquela constatada nos estudos supracitados, que registraram uma maior produtividade desse item como verbo gramatical. No bojo dessa discussão, realizou-se uma análise acústica da construção [deixa eu] em comparação com a forma de terceira pessoa do presente do indicativo, a fim de mensurar o grau de redução da construção e verificar se ela é mais reduzida tanto do ponto de vista paradigmático em relação à forma [deixa], conforme depreende-se do estudo de Bybee et al. (2016), como também do ponto de vista sintagmático, isto é, em relação às suas palavras contíguas, o que permitiria atestar efetivamente o seu grau de redução comparado à forma [deixa]. A pesquisa revelou que há mais usos do verbo com função discursiva, manifestados pela construção [deixa eu], seguidos da função gramatical e da função lexical. Não obstante, considerou-se que a função gramatical não está enraizada no verbo, mas na construção de que ele participa, o que permite assumir que ele passa por um processo de construcionalização. A análise acústica, por sua vez, revelou que a construção [deixa eu] é do ponto de vista sintagmático mais reduzida do que a forma [deixa], o que evidencia que ela se encontra num estágio mais avançado de mudança, caracterizado por sua função de marcador discursivo.
polissemia da construção relacional binominal SN1 de SN2 no Português Brasileiro
Authors: Santos Carolina Piechotta Martins , Alonso Karen Sampaio Braga
Published: March 2022

Neste trabalho, buscamos descrever a construção relacional binominal do tipo SN1 de SN2 no português brasileiro, em termos dos diferentes sentidos associados a ela, tais como parte-todo, localização, especialização etc. A hipótese geral é a de que esses sentidos compartilham propriedades entre si e formam um continuum entre dois domínios – o da POSSE e o da TIPIFICAÇÃO. Baseamos nossa análise no argumento de que construções do tipo SN1 de SN2 se relacionam a um esquema que evoca a habilidade de ponto de referência, nos termos de Langacker (1991; 2003). Em termos teórico-epistemológicos, partimos da perspectiva da Linguística Baseada no Uso. Para demonstrar a polissemia da construção, foi feita uma análise qualitativa de dados no Corpus do Português, em que se procurou descrever como os diferentes sentidos se relacionam e se distribuem daqueles mais prototipicamente associados ao domínio da POSSE, passando pelos que vão se distanciando das relações possessivas e chegando até os mais prototípicos do domínio da TIPIFICAÇÃO.
A posição da oração completiva em construções subjetivas
Authors: Dias Nilza Barrozo , Da Silva Angelina Maganha Grigorio
Published: March 2022

Neste artigo, investigam-se construções subjetivas de modalização (deôntica e epistêmica) e de avaliação, sob a perspectiva de modelos centrados no uso (BOYLAND, 2009; KEMMER; BARLOW, 1999), especialmente pressupostos da Linguística Centrada no Uso, que, segundo Diessel (2017) e Bybee (2016), apresenta aporte de base Funcionalista e da Linguística Cognitiva. Acrescente-se a contribuição da Gramática do Design Visual na dinâmica da construção subjetiva nos memes/postagens. As construções subjetivas são denominadas de construções subjetivas deônticas, subjetivas epistêmicas e subjetivas avaliativas, constituídas sintaticamente por oração matriz seguida da oração completiva subjetiva. A partir de 214 dados de uso coletados do site da rede social Facebook, observamos que a motivação discursiva determina a ordem da oração subjetiva avaliativa em relação à sua matriz, já que a topicalização da subjetiva na construção subjetiva avaliativa apresenta resultados bastante expressivos. Contrariamente, a construção subjetiva epistêmica preza pela posposição categórica da oração completiva. A oração matriz pode ser vista como um chunking, uma unidade sequencial que projeta impessoalização; a esquematização da categoria apresenta um slot que se realiza como adjetivo, sendo a construção parcialmente esquemática porque o adjetivo que preenche o slot varia entre os avaliativos, os deônticos e os epistêmicos. Do ponto de vista textual-discursivo a construção subjetiva funciona como uma “ilha” de valor impessoal, genérico, que é cercada por informações pessoais e experiências pessoais.
Casar x Noivar
Authors: S. Ciríaco Larissa , De Sá Thaís M. M. , Dos Santos Clarice F.
Published: March 2022

Neste artigo, investiga-se a ocorrência de um tipo de construção causativa em português brasileiro, e que pode ser exemplificada pela sentença “O pai casou a filha”. Neste trabalho, essa construção será chamada especificamente de ação-causada2, a fim de capturar tanto as semelhanças quanto as diferenças em relação à construção de ação-causada descrita em Santos, Ciríaco e Souza (2019). Embora restrita a poucos verbos, o significado oracional da construção de ação-causada tem se tornado bastante usual em PB. Uma evidência do aumento de situações de uso reais dessa construção vem de redes sociais, em que expressões que estendem o significado de ação causada para novos contextos, como “casando a irmã”, “formando o amigo”, podem ser facilmente observadas. Com base na abordagem baseada no uso da Gramática de Construções (GOLDBERG, 1995, 2006, 2019), este artigo investiga os aspectos funcionais envolvidos na compatibilização entre verbo e construção de ação causada2 em português brasileiro a partir de uma análise de dados de corpora e de redes sociais. Defende-se que essas construções são restritas por um cenário convencionalizado de investimento pessoal, seja ele financeiro, emocional ou social.
Sağlıkta Şiddetin Önlenmesine Yönelik Yapılan Nisan 2020 Tarihli Yasal Düzenlemenin İncelenmesi
Authors: Taştemir S. Yazgülü , Akay Arda , Balcı Işılay , Yorulmaz A. Coşkun
Published: March 2022

Violence has been accepted as an important public health problem by the World Health Organization (WHO) as of 2002. As in every discipline, the concept of violence has been defined in different ways in studies dealing with violence against healthcare workers. According to the World Health Organization; violence is defined as "the intentional use of physical force or power, threatened or actual, against oneself, another person, or against a group or community, that either results in or has a high likelihood of resulting in injury, death, psychological harm, maldevelopment, or deprivation. “As in the rest of the world, there are incidents of violence against healthcare workers in our country and researches and arrangements are made on this subject both in academic level and in terms of social policies. In this study, the regulation that came into force on 17.04.2020 for the prevention of violence against healthcare workers in our country will be examined.
La protección de lo sagrado en Francia: de las caricaturas a la ley para reforzar el respeto a los valores de la república
Authors: Innerarity Grau Carmen
Published: March 2022

Este trabajo analiza el conflicto planteado en Francia a raíz de la publicación de las caricaturas de Mahoma, renovado actualmente por la celebración del juicio por los atentados del año 2015 y que ha impulsado, entre otras razones, el proyecto de ley para reforzar los valores de la república. Parte de la idea de que este tipo de cuestiones requiere un enfoque político-normativo, que evalúe las instituciones y los procedimientos —la laicidad, en este caso— atendiendo a los valores que las justifican —la igualdad— y al contexto en el que actúan. A partir de la distinción entre los diferentes planos de las caricaturas (su publicación, su contenido burlesco y la asociación con la violencia) muestra, en primer lugar, un posible acercamiento desde los criterios establecidos por el Consejo de Europa sobre los límites de la libertad de expresión. Continúa con la exposición de una perspectiva político-normativa, tomando como referencia los valores que propone reforzar el proyecto de ley francés para combatir el islamismo radical. Concluye, además de la insuficiencia de un enfoque meramente legal, que este tipo de valores se convierten en algo intangible, algo que no admite la crítica, contribuyendo a reforzar el asimilacionismo típicamente francés, en detrimento del valor de la igualdad.
Ecopolitical Mapping: A Multispecies Research Methodology for Environmental Communication
Authors: Benöhr Jens , Brinksma Maike , Donihue Ross , Farò David , Lara Antonia , Virik Kara Lena , Ponce de León Alejandro , Toro Cristian , Gygli Bastian , Romo Daniel , Walther Franziska E.
Published: March 2022

Ecopolitical Mapping is a methodology which seeks to map encounters of love and disaster between humans and their more-than-human surroundings. This methodology, first coined by an transdisciplinary group of artists and researchers in South Chile, unfolds through collective mapping sessions using an ecopolitical approach to trace the power relationships between different species-beings. In this research document, we unpack our engagements with this methodology in three different scales and territories: the Biobío Watershed (Chile), Berlin City (Germany) and Europe (Continent). Each case presented a strong environmental communication component, which ended up with the translation of the stories of the encounters into illustrated maps. The methodological approach proposed here is intimate, political and situated. The map evolves from a supposed politically neutral artifact into a tool for environmental education, communication, and activism. We offer the notionand approach, hoping that this methodology can be practiced and refined by other humans, allies of the tentacle kinship.
A study of ocular manifestations in HIV positive patients
Authors: Morskole Sheetal , Som Vivek , Dubey Aditi , Kumar Kavita , Bamhane Preeti , Tekam Dev Kumar
Published: March 2022

: The present study aimed to determine the prevalence and pattern of ocular manifestation in HIV positive patients and to correlate ocular lesions with CD4 counts in HIV positive patients.

The study was conducted as an observational study on seropositive HIV patients attending ART center and OPD department of ophthalmology during the study period of 2 years. Detailed sociodemographic and clinical history was obtained. Patients were subjected to thorough ophthalmologic evaluation and necessary investigations and findings were noted.

Ocular manifestations could be observed in 36 (52.2%) cases. Among them, unilateral ocular manifestations were observed in 11 (15.9%) cases and bilateral involvement in 25 (36.2%) out of 69 patients. A wide spectrum of ocular manifestations were observed, most commonly of posterior segment. Ocular manifestations were not significantly associated with CD4 count (p>0.05) except CMV retinitis which was significantly associated with lower CD4 count (<150 in 14.3% cases). Papilledema was significantly associated with higher CD4 count (p<0.05).

Ocular manifestations in HIV positive patients has a wide range of presentation. Every HIV patient must be educated about their ocular condition and should be advised to undergo regular ophthalmic examinations. Health care professionals also should be educated and trained in every aspect so as to pick up early cases of ophthalmic manifestations of HIV and should have coordination with ART center for easy assessment, detection and treating of vision-threatening ocular lesions at the earliest possible.
Numerical Study of Laminar Bingham Fluid in Axisymmetric Sudden Expansion
Authors: Bekhadra Mokhtar , Chemloul Nord-Eddine Sad , Menouer Abdelfettah , Chaib Khaled
Published: March 2022

A numerical study was carried out to investigate the laminar flow of Bingham fluid through an axisymmetric sudden expansion of four aspect ratios and various values of Reynolds number between [50~200] and Bingham number [0~2]. By using the commercial code Ansys-Fluent, this paper focuses on presenting Bingham's flow through an axisymmetric sudden expansion to determine the length and intensity of recirculation zones and shed light on the local loss coefficient. The results show an increase in the reattachment length and the eddy intensity of the recirculation zones by increasing the Reynolds number and the aspect ratio and decreasing with increasing the Bingham number and vice versa, the local loss coefficient increases as the aspect ratio increases for the Newtonian fluid this effect is reflected in the Bingham fluid, the increase of the Bingham number also increases the local loss coefficient, dimensionless equations has built to predict all the reattachment lengths, the eddy intensity and the local loss coefficient.
The Cylinder Liner Temperature Distribution Evaluation of a Diesel Engine Operating with M10, E10, and B10 Fuels
Authors: Trung Kien Nguyen , Trong Quy Nguyen
Published: March 2022

Internal combustion engines are currently so well-optimized that enhancing their performance is a prohibitively expensive endeavor. The success of the engine simulation approach is determined by the accuracy of the heat transfer model. The purpose of these models is to figure out how much heat is transferred from the combustion gases to the cylinder walls. To see which of these relationships may best explain the experimental data for internal combustion engines utilizing various fuel mixtures. The cylinder liner temperature distribution of a diesel engine running on M10, E10, and B10 fuels is presented in this research using the Hohenberg correlation. The results demonstrate that when alcohol is added to mineral diesel fuel, the maximum temperature of the cylinder liner rises by 5.4 percent, 3.7 percent, and 2.23 percent, respectively, allowing the engine to run safely with diesel-alcohol dual fuel.
2000’li Yıllardan Günümüze Türkiye Ekonomisinde Genç İşsizlik Sorunu ve Çözüm Önerileri
Authors: Tekin Ayşe
Published: April 2022

Türkiye dinamik bir genç nüfusa sahiptir ancak bir taraftan da genç işsizlik sorunu ile mücadele etmektedir. Eğitim sistemi ile işgücü piyasası arasındaki uyuşmazlıklar, yeni iş sahalarının oluşturulamaması, göç ve tarımdaki çözülmeler gibi sorunlar genç işsiz sayısını arttırmaktadır. Genç nüfusun ilerleyen yıllarda aynı dinamikliğini koruyamayacak olması da genç işsizlik sorununa zamanında çözüm bulunması gerçekliğini ortaya koymaktadır. Çalışmanın temelini genç işsizlik sorununun sebepleri, genç işsizlikle birlikte ortaya çıkan sorunlar ve genç işsizlik sorunu için ortaya atılan çözüm önerileri oluşturmaktadır. Türkiye’de genç işsizliğin boyutları, genç nüfusun işgücü nitelikleri gibi konular 2000’li yıllardan günümüze kadar incelenecek ve ortaya çıkan sonuçlar tablo ve grafikler yardımı ile değerlendirilecektir.
Anahtar Kelimeler: Genç İşsizlik, Türkiye, Eğitim, İstihdam
JEL Sınıflandırması: E24
The Role of House Prices in Monetary Transmission Mechanism: Evidence from Turkish Economy
Authors: Şahin Kutlu Şeyma
Published: April 2022

It is possible for central banks to carry out their policies effectively by making the correct assessment of the reflection of their monetary policy decisions on real economic activities. For this reason, it is important to examine the effects of applied policies on real economic activities and inflation. Accordingly, the 2008 global financial crisis revealed the importance of the relationship between monetary policy, house prices, and real economic activity, in other words, the channel of transmission of house prices. As a matter of fact, developments in the housing industry have a significant impact on the process leading up to the 2008 Global financial crisis. In this context, after the 2008 Global financial crisis, both the role of house prices in monetary policy implementation and the function of house prices in the transmission mechanism has begun to be questioned. In this study, the effectiveness of the house prices transmission channel, a subgroup of the asset prices channel based on the experience of the 2008 Global financial crisis, was empirically analyzed based on the Turkish economy. The VAR model has been preferred as a method of empirical analysis. The analysis covers the period 2010-2019, and the monthly data set is used in the analysis. The results of the analysis show that monetary policy affects house prices, but house prices do not have a statistically significant effect on housing investment, industrial production index, and inflation. Related results show that the housing prices transmission channel is not active in the Turkish economy.
Key Words: Monetary Transmission Mechanism, House Prices, VAR Model
JEL Classification: E52
Türkiye Selçuklu Devleti Maliyesini İbn-i Haldun ile Anlamak: Mali Sosyolojik Bir Yaklaşım
Authors: Ağdemir Zeynep
Published: April 2022

Bu çalışmanın temel amacı, Türkiye Selçuklu Devletinin mali yapısını geleneksel maliye tarihi yaklaşımının dışında İbn-i Haldun’un mali sosyolojisi ile incelemek ve böylelikle İbn-i Haldun’un mali sosyolojisinin Doğu coğrafyasını anlamak için sağladığı özgünleri anlamaya çalışmaktır. Bu bağlamda, öncelikle İbn-i Haldun’un mali sosyolojisinde devlet-maliye ilişkisi anlaşılmaya çalışılacaktır. Yazının ilk bölümünde, İbn-i Haldun’un sosyolojisinde devletin gelişim aşamaları ile maliyede gerçekleşen dönüşümler serimlenecektir. Ardından, Türkiye Selçuklu Devleti, İbn-i Haldun’un sosyolojisindeki devletin aşamaları çerçevesinde değerlendirilecek, bu aşamalara denk düşen mali olaylar analiz edilecektir. Sonuç olarak ise İbn-i Haldun’un mali sosyolojisinin Türkiye Selçuklu Devletinin mali yapısını değerlendirmek ve maliye tarihi açısından çeşitli özgünleri kavramak için ne tür imkanlar sağladığı tartışılacaktır.
Anahtar Kelimeler: İbn-i Haldun, Türkiye Selçuklu Devleti, devletin aşamaları, vergi.
JEL Sınıflandırması: N4, N45, H2, H3.
Constructing Crime in a Database: Big Data and the Mangle of Social Problems Work
Authors: Sanders Carrie B. , Christensen Tony , Weston Crystal
Published: March 2022

This paper argues for programmatic change within social constructionist approaches to social problems by attending to materiality in the theoretical conception of social context. To illustrate how this might be done, we place the interplay between social problems construction and technology (what we refer to as the mangle of social problems work) at its center by examining how the advent of “big data” is impacting the construction of social problems. Using the growing field of intelligence-led policing (ILP) as our illustrative example, we will examine four effects the large scale collection and analysis of data has on the way social problems claims are made. We begin by arguing that big data offers a new method by which putative problems are discovered and legitimized. We then explore how large data sets and algorithmic data analysis are increasingly used for predicting future problems. Following this, we illustrate how big data is used to construct and implement solutions to future problems. Lastly, we use the interplay between big data and those who use it to illustrate “the mangle of social problems work,” where data is made meaningful and actionable through the interpretive and analytic processes of analysts and police officers.
Social Constructionism Turned Into Human Service Work
Authors: Järvinen Margaretha , Miller Gale
Published: March 2022

Studies of applied constructionism are opportunities for scholars to explore how social constructionism is a resource used by claims-makers in describing and justifying their orientations to professional practice. The present paper expands sociological constructionism by analyzing applied constructionism in social problems work in Copenhagen, Denmark. Based on interviews with staff members in narrative drug treatment, we explore two themes: the relationship between dominant and liberating narratives and the position of expert knowledge in narrative therapy. Our guiding framework is Ian Hacking’s inquiry into the Social Construction of What? and Kenneth Burke’s dialogic approach of comparing statements to counterstatements. The purpose of the paper is to link academic studies of the social construction of realities to applied constructionists’ principles in addressing social problems. We do this by describing narrative therapists’ critical reflections on their own work, suggesting that these reflections are not only useful when it comes to developing narrative therapy but also for the advancement of academic constructionism.
Subiektywna ocena rozmiarów ciała
Authors: Strzałko Jan , Lewicki Piotr K T. , Kaszycka Katarzyna
Published: March 2022

The subjective estimation of the body dimensions was investigated on 1372 school-children of both sexes aged 11-18 years. The analysis of the consistency of estimations (selfestimations and mutual estimations) with the real values of the particular traits (stature, body weight and hand muscle strength) permitted to draw conclusions referring to the perception of the morphological diversity, of man.
Noworodek – stan rozwoju fizycznego i trendy rozwojowe urodzeniowej masy ciała
Authors: Kaliszewska-Drozdowska Maria Danuta
Published: March 2022

Having continued the research carried out in 1960 and 1970, the sample of 1620 newborns (762 girls and 858 boys) born in 1986 in Poznan were examined. Measurments of: body mass (1), si length (2), head circumference(3) and chest circumference (4) as well as the values of indices (1/2,3/4) were shown in the tables and on the graphs.
Zmienność somatyczna a sprawność mechanizmów termoregulacyjnych
Authors: Gołąb Stanisław , Tyka Aleksander
Published: March 2022

Somatic variability and the efficiency of thermoregulating mechanisms was examined on the samples of Thais, Poles and Finns. The intergroup differences indicate the connection with the climatic zones. Thermoregulating efficiency seems to correlate with body built.
Drogi awansu chłopów polskich w świetle wskaźników antropologicznych
Authors: Welon Zygmunt
Published: March 2022

The hypothesis that the rise was achieved mainly owing to the leaving the farming or by moving to towns, was proved. Military conscripts (20,085) were divided into 10 appropriate social groups. Social status was measured by use of stature, educational level and health cathegory of conscripts.
Badanie zawartości ołowiu, kadmu, miedzi i cynku w stałych zębach mieszkańców Polski południowej
Authors: Szostek Krzysztof
Published: March 2022

Lead, cadmium, copper and zinc concenrations in permanent teeth in the population of southern Poland were analysed by AAS technique. There was a statistically significant correlation between the quantities of heavy metals and the age of subjects. Also determined there were the sex differences and the relationship between the environmental conditions and the level of the accumulated heavy metals.
Analysis of Transmissible and Nontransmissible Components of Variation in Human Physique
Authors: Kaczmarek Maria
Published: March 2022

The paper is aimed at decomposition the continuously varying phenotype into components due to transmissible and nontransmissible factors. The linear causal model (path analysis) was applied to incorporate the contribution of environmental sources of variation (described in terms of indices of socioeconomic status) to familial resemblance on physique (height and weight) in 342 nuclear families. Parameters of the causal model were estimated according to the TAU transmission model of Rice, Cloninger, Reich [1978] and linear constraints placed upon the parameters were tested. The proportion of total phenotypic variance accounted for by genetic and environmental transmissible factors was estimated to be 62% for height and 38% for weight.