bluuebunny/crossref_metadata_2025 huggingface dataset:
Why do people with chronic disease not contact consumer health organisations? A survey of general practice patients
Authors: Boyle Frances M. , Dean Julie H. , Young Charlotte E. , Mutch Allyson J.
Published: November 2015

Aim

Consumer health organisations (CHOs) are non-profit or voluntary sector organisations that promote and represent the interests of patients and carers affected by particular conditions. The purpose of this study was to examine, among patients with chronic disease, what differentiates those who contact CHOs from those who do not and what stops people from making contact.

Background

CHOs can enhance people’s capacity to manage chronic disease by providing information, education and psychosocial support, but are under-utilised. Little is known about barriers to access.

Methods

Data were from a baseline telephone survey conducted as part of a randomised trial of an intervention to improve access to CHOs. Participants constituted a consecutive sample of 276 adults with diagnosed chronic disease recruited via 18 general practitioners in Brisbane, Australia. Quantitative survey items examined participants’ use and perceptions of CHOs and a single open-ended question explored barriers to CHO use. Multiple logistic regression and thematic analysis were used.

Findings

Overall, 39% of participants had ever contacted a CHO for their health and 28% had contacted a CHO specifically focussed on their diagnosed chronic condition. Diabetes, poorer self-reported physical health and greater health system contact were significantly associated with CHO contact. The view that ‘my doctor does it all’ was prevalent and, together with a belief that their health problems were ‘not serious enough’, was the primary reason patients did not make contact.

Conclusion

Attitudinal and system-related barriers limit use of CHOs by those for whom they are designed. Developing referral pathways to CHOs and promoting awareness about what they offer is needed to improve access.
Building Relationships in a Cold Climate: A Case Study of Family Engagement within an ‘Edge of Care’ Family Support Service
Authors: Sen Robin
Published: November 2015

Drawing on a case study generated as part of a larger evaluation, this article explores engagement between one family and an ‘edge of care’ intensive family support service, within a cold climate of public spending cuts and rising numbers of children in care. The focus on engagement in the case study illustrates theories about relationship building at the ‘edge of care’: the importance of an empathic relationship; harnessing parents’ agency for change while raising child welfare concerns; allowing parents space to maintain a positive self-conception of parenthood while supporting improvements; and engagement with family practices. The case study highlights that, despite the potential disciplinary aspects of intensive family support, the parents valued the ‘edge of care’ service because it provided them with the help they felt they needed, contrasting with their prior experience of statutory child welfare agency practice.
Embedded Integration and Organisational Change in Housing Providers in the UK
Authors: Phillimore Jenny
Published: November 2015

The arrival of large numbers of asylum seekers in the UK, many of whom subsequently become refugees, has been an important contributor to the emergence of new migration. Integration policy and initiatives have placed a great deal of focus on securing housing for refugees and enhancing their employability. While academics stress that integration should be a two-way process, and highlight the need for institutions to adapt to meet migrant need, the vast majority of policy attention has focused on supporting refugees to adapt to life in the UK. Few initiatives and even less research attention has been paid to encouraging or exploring institutional adaptation. This article looks at the experiences of UK housing providers involved in the HACT Reach In initiative. The project was unusual in that it sought to encourage housing providers to adapt their approaches to service provision by embedding refugees into their everyday work. Using data collected via qualitative longitudinal methods, the article examines the ways in which institutions changed their cultures and approaches to service delivery. It finds that initiatives that enable hosts and migrants to access new social fields create the opportunity for embedded integration that moves beyond the individual to impact upon institutions, and argues that shifting our attention to institutions has much to offer in conceptual, empirical and policy terms.
Optimal reinsurance under multiple attribute decision making
Authors: Bulut Karageyik Başak , Dickson David C.M.
Published: November 2015

We apply methods from multiple attribute decision making (MADM) to the problem of selecting an optimal reinsurance level. In particular, we apply the Technique for Order of Preference by Similarity to Ideal Solution method with Mahalanobis distance. We consider the classical risk model under a reinsurance arrangement – either excess of loss or proportional – and we consider scenarios that have the same finite time ruin probability. For each of these scenarios we calculate three quantities: released capital, expected profit and expected utility of resulting wealth. Using these inputs, we apply MADM to find optimal retention levels. We compare and contrast our findings with those when decisions are based on a single attribute.
Improving Representation of Snow on Sea Ice in Climate Models
Authors: Perovich Don , Holland Marika , Hunke Elizabeth
Published: November 2015

Snow on Sea Ice Workshop; Barrow, Alaska, 29 April to 1 May 2015
The effect of microbial colonization on the host proteome varies by gastrointestinal location
Authors: Lichtman Joshua S , Alsentzer Emily , Jaffe Mia , Sprockett Daniel , Masutani Evan , Ikwa Elvis , Fragiadakis Gabriela K , Clifford David , Huang Bevan Emma , Sonnenburg Justin L , Huang Kerwyn Casey , Elias Joshua E
Published: November 2015

Endogenous intestinal microbiota have wide-ranging and largely uncharacterized effects on host physiology. Here, we used reverse-phase liquid chromatography-coupled tandem mass spectrometry to define the mouse intestinal proteome in the stomach, jejunum, ileum, cecum and proximal colon under three colonization states: germ-free (GF), monocolonized with Bacteroides thetaiotaomicron and conventionally raised (CR). Our analysis revealed distinct proteomic abundance profiles along the gastrointestinal (GI) tract. Unsupervised clustering showed that host protein abundance primarily depended on GI location rather than colonization state and specific proteins and functions that defined these locations were identified by random forest classifications. K-means clustering of protein abundance across locations revealed substantial differences in host protein production between CR mice relative to GF and monocolonized mice. Finally, comparison with fecal proteomic data sets suggested that the identities of stool proteins are not biased to any region of the GI tract, but are substantially impacted by the microbiota in the distal colon.
Erratum: Enrichment of DNRA bacteria in a continuous culture
Authors: van den Berg Eveline M , van Dongen Udo , Abbas Ben , van Loosdrecht Mark C M
Published: November 2015

Correction to: The ISME Journal (2015) 9, 2153–2161; doi:10.1038/ismej.2015.26; published online 24 April 2015 Since the publication of this paper, the author has noticed an error in the third paragraph of Materials and Methods (under ‘Chemostat reactor operation’). It should read as follows (changes are underlined):
Erratum: Structural isomerism in gold nanoparticles revealed by X-ray crystallography
Authors: Tian Shubo , Li Yi-Zhi , Li Man-Bo , Yuan Jinyun , Yang Jinlong , Wu Zhikun , Jin Rongchao
Published: November 2015

Nature Communications 6: Article number: 8667 (2015); Published: 20 October 2015; Updated: 17 November 2015. The original version of this Article contained an error in the spelling of isomerism in the title of the paper. This has now been corrected in both the PDF and HTML versions of the Article.
On the decline of biodiversity due to area loss
Authors: Keil Petr , Storch David , Jetz Walter
Published: November 2015

Predictions of how different facets of biodiversity decline with habitat loss are broadly needed, yet challenging. Here we provide theory and a global empirical evaluation to address this challenge. We show that extinction estimates based on endemics–area and backward species–area relationships are complementary, and the crucial difference comprises the geometry of area loss. Across three taxa on four continents, the relative loss of species, and of phylogenetic and functional diversity, is highest when habitable area disappears inward from the edge of a region, lower when it disappears from the centre outwards, and lowest when area is lost at random. In inward destruction, species loss is almost proportional to area loss, although the decline in phylogenetic and functional diversity is less severe. These trends are explained by the geometry of species ranges and the shape of phylogenetic and functional trees, which may allow baseline predictions of biodiversity decline for underexplored taxa.
Recurrent internal tandem duplications of BCOR in clear cell sarcoma of the kidney
Authors: Roy Angshumoy , Kumar Vijetha , Zorman Barry , Fang Erica , Haines Katherine M. , Doddapaneni HarshaVardhan , Hampton Oliver A. , White Simon , Bavle Abhishek A. , Patel Nimesh R. , Eldin Karen W. , John Hicks M. , Rakheja Dinesh , Leavey Patrick J. , Skapek Stephen X. , Amatruda James F. , Nuchtern Jed G. , Chintagumpala Murali M. , Wheeler David A. , Plon Sharon E. , Sumazin Pavel , Parsons D. Williams
Published: November 2015

The X-linked BCL-6 co-repressor (BCOR) gene encodes a key constituent of a variant polycomb repressive complex (PRC) that is mutated or translocated in human cancers. Here we report on the identification of somatic internal tandem duplications (ITDs) clustering in the C terminus of BCOR in 23 of 27 (85%) pediatric clear cell sarcomas of the kidney (CCSK) from two independent cohorts. We profile CCSK tumours using a combination of whole-exome, transcriptome and targeted sequencing. Identical ITD mutations are found in primary and relapsed tumour pairs but not in adjacent normal kidney or blood. Mutant BCOR transcripts and proteins are markedly upregulated in ITD-positive tumours. Transcriptome analysis of ITD-positive CCSKs reveals enrichment for PRC2-regulated genes and similarity to undifferentiated sarcomas harbouring BCOR–CCNB3 fusions. The discovery of recurrent BCOR ITDs defines a major oncogenic event in this childhood sarcoma with significant implications for diagnostic and therapeutic approaches to this tumour.
Divalent metal-ion transporter 1 is decreased in intestinal epithelial cells and contributes to the anemia in inflammatory bowel disease
Authors: Wu Wei , Song Yang , He Chong , Liu Changqin , Wu Ruijin , Fang Leilei , Cong Yingzi , Miao Yinglei , Liu Zhanju
Published: November 2015

Divalent metal-ion transporter 1 (DMT1) has been found to play an important role in the iron metabolism and hemogenesis. However, little is known about the potential role of DMT1 in the pathogenesis of anemia from patients with inflammatory bowel disease (IBD). Herein, we investigated expression of DMT1 in the intestinal mucosa by quantitative real-time polymerase chain reaction (qRT-PCR) and immunohistochemistry and found that DMT1 was significantly decreased in the inflamed mucosa of active IBD patients compared with that in those patients at remission stage and healthy controls. To further study the mechanism, we cultured HCT 116 cell line in vitro. Expression of DMT1 in HCT116 was demonstrated to be markedly decreased under stimulation with TNF for 24 and 48 h, while JNK inhibitor (JNK-IN-7) could significantly reverse the decrease. Interestingly, anti-TNF therapy successfully improved anemia in clinical responsive Crohn’s disease patients and DMT1 was found to be markedly up-regulated in intestinal mucosa. Taken together, our studies demonstrate that decreased expression of DMT1 in intestinal mucosa leads to compromised absorption and transportation of iron and that blockade of TNF could rescue anemia and promote DMT1 expression in gut mucosa. This work provides a therapeutic approach in the management of anemia in IBD.
Association of specific frequency bands of functional MRI signal oscillations with motor symptoms and depression in Parkinson’s disease
Authors: Song Xiaopeng , Hu Xiao , Zhou Shuqin , Xu Yuanyuan , Zhang Yi , Yuan Yonggui , Liu Yijun , Zhu Huaiqiu , Liu Weiguo , Gao Jia-Hong
Published: November 2015

A novel empirical mode decomposition method was adopted to investigate the dissociative or interactive neural impact of depression and motor impairments in Parkinson’s disease (PD). Resting-state fMRI data of 59 PD subjects were first decomposed into characteristic frequency bands and the main effects of motor severity and depression and their interaction on the energy of blood-oxygen-level-dependent signal oscillation in specific frequency bands were then evaluated. The results show that the severity of motor symptoms is negatively correlated with the energy in the frequency band of 0.10–0.25 Hz in the bilateral thalamus, but positively correlated with 0.01–0.027 Hz band energy in the bilateral postcentral gyrus. The severity of depression, on the other hand, is positively correlated with the energy of 0.10–0.25 Hz but negatively with 0.01–0.027 Hz in the bilateral subgenual gyrus. Notably, the interaction between motor and depressive symptoms is negatively correlated with the energy of 0.10–0.25 Hz in the substantia nigra, hippocampus, inferior orbitofrontal cortex and temporoparietal junction, but positively correlated with 0.02–0.05 Hz in the same regions. These findings indicate unique associations of fMRI band signals with motor and depressive symptoms in PD in specific brain regions, which may underscore the neural impact of the comorbidity and the differentiation between the two PD-related disorders.
Sustainable production of valuable compound 3-succinoyl-pyridine by genetically engineering Pseudomonas putida using the tobacco waste
Authors: Wang Weiwei , Xu Ping , Tang Hongzhi
Published: November 2015

Treatment of solid and liquid tobacco wastes with high nicotine content remains a longstanding challenge. Here, we explored an environmentally friendly approach to replace tobacco waste disposal with resource recovery by genetically engineering Pseudomonas putida. The biosynthesis of 3-succinoyl-pyridine (SP), a precursor in the production of hypotensive agents, from the tobacco waste was developed using whole cells of the engineered Pseudomonas strain, S16dspm. Under optimal conditions in fed-batch biotransformation, the final concentrations of product SP reached 9.8 g/L and 8.9 g/L from aqueous nicotine solution and crude suspension of the tobacco waste, respectively. In addition, the crystal compound SP produced from aqueous nicotine of the tobacco waste in batch biotransformation was of high purity and its isolation yield on nicotine was 54.2%. This study shows a promising route for processing environmental wastes as raw materials in order to produce valuable compounds.
Superresolution imaging with optical fluctuation using speckle patterns illumination
Authors: Kim MinKwan , Park ChungHyun , Rodriguez Christophe , Park YongKeun , Cho Yong-Hoon
Published: November 2015

Superresolution fluorescence microscopy possesses an important role for the study of processes in biological cells with subdiffraction resolution. Recently, superresolution methods employing the emission properties of fluorophores have rapidly evolved due to their technical simplicity and direct applicability to existing microscopes. However, the application of these methods has been limited to samples labeled with fluorophores that can exhibit intrinsic emission properties at a restricted timescale, especially stochastic blinking. Here, we present a superresolution method that can be performed using general fluorophores, regardless of this intrinsic property. Utilizing speckle patterns illumination, temporal emission fluctuation of fluorophores is induced and controlled, from which a superresolution image can be obtained exploiting its statistical property. Using this method, we demonstrate, theoretically and experimentally, the capability to produce subdiffraction resolution images. A spatial resolution of 500 nm, 300 nm and 140 nm with 0.4, 0.5 and 1.4 NA objective lenses respectively was achieved in various samples with an enhancement factor of 1.6 compared to conventional fluorescence microscopy.
Erratum: Meat, dairy and plant proteins alter bacterial composition of rat gut bacteria
Authors: Zhu Yingying , Lin Xisha , Zhao Fan , Shi Xuebin , Li He , Li Yingqiu , Zhu Weiyun , Xu Xinglian , Li Chunbao , Zhou Guanghong
Published: November 2015

Long-term consumption of red meat has been considered a potential risk to gut health, but this is based on clinic investigations, excessive intake of fat, heme and some injurious compounds formed during cooking or additions to processed meat products. Whether intake of red meat protein affects gut bacteria and the health of the host remains unclear. In this work, we compared the composition of gut bacteria in the caecum, by sequencing the V4-V5 region of 16S ribosomal RNA gene, obtained from rats fed with proteins from red meat (beef and pork), white meat (chicken and fish) and other sources (casein and soy). The results showed significant differences in profiles of gut bacteria between the six diet groups. Rats fed with meat proteins had a similar overall structure of caecal bacterial communities separated from those fed non-meat proteins. The beneficial genus Lactobacillus was higher in the white meat than in the red meat or non-meat protein groups. Also, rats fed with meat proteins and casein had significantly lower levels of lipopolysaccharide-binding proteins, suggesting that the intake of meat proteins may maintain a more balanced composition of gut bacteria, thereby reducing the antigen load and inflammatory response in the host.
Structural insights into the reaction mechanism of S-adenosyl-L-homocysteine hydrolase
Authors: Kusakabe Yoshio , Ishihara Masaaki , Umeda Tomonobu , Kuroda Daisuke , Nakanishi Masayuki , Kitade Yukio , Gouda Hiroaki , Nakamura Kazuo T. , Tanaka Nobutada
Published: November 2015

S-adenosyl-L-homocysteine hydrolase (SAH hydrolase or SAHH) is a highly conserved enzyme that catalyses the reversible hydrolysis of SAH to L-homocysteine (HCY) and adenosine (ADO). High-resolution crystal structures have been reported for bacterial and plant SAHHs, but not mammalian SAHHs. Here, we report the first high-resolution crystal structure of mammalian SAHH (mouse SAHH) in complex with a reaction product (ADO) and with two reaction intermediate analogues—3’-keto-aristeromycin (3KA) and noraristeromycin (NRN)—at resolutions of 1.55, 1.55 and 1.65 Å. Each of the three structures constitutes a structural snapshot of one of the last three steps of the five-step process of SAH hydrolysis by SAHH. In the NRN complex, a water molecule, which is an essential substrate for ADO formation, is structurally identified for the first time as the candidate donor in a Michael addition by SAHH to the 3’-keto-4’,5’-didehydroadenosine reaction intermediate. The presence of the water molecule is consistent with the reaction mechanism proposed by Palmer & Abeles in 1979. These results provide insights into the reaction mechanism of the SAHH enzyme.
The influence of whispering gallery modes on the far field of ring lasers
Authors: Szedlak Rolf , Holzbauer Martin , MacFarland Donald , Zederbauer Tobias , Detz Hermann , Andrews Aaron Maxwell , Schwarzer Clemens , Schrenk Werner , Strasser Gottfried
Published: November 2015

We introduce ring lasers with continuous π-phase shifts in the second order distributed feedback grating. This configuration facilitates insights into the nature of the modal outcoupling in an optical cavity. The grating exploits the asymmetry of whispering gallery modes and induces a rotation of the far field pattern. We find that this rotation can be connected to the location of the mode relative to the grating. Furthermore, the direction of rotation depends on the radial order of the whispering gallery mode. This enables a distinct identification and characterization of the mode by simple analysis of the emission beam.
Targeted Proteomics Enables Simultaneous Quantification of Folate Receptor Isoforms and Potential Isoform-based Diagnosis in Breast Cancer
Authors: Yang Ting , Xu Feifei , Fang Danjun , Chen Yun
Published: November 2015

The distinct roles of protein isoforms in cancer are becoming increasingly evident. FRα and FRβ, two major isoforms of the folate receptor family, generally have different cellular distribution and tissue specificity. However, the presence of FRβ in breast tumors, where FRα is normally expressed, complicates this situation. Prior to applying any FR isoform-based diagnosis and therapeutics, it is essential to monitor the expression profile of FR isoforms in a more accurate manner. An LC-MS/MS-based targeted proteomics assay was developed and validated in this study because of the lack of suitable methodology for the simultaneous and specific measurement of highly homologous isoforms occurring at low concentrations. FRα and FRβ monitoring was achieved by measuring their surrogate isoform-specific peptides. Five human breast cell lines, isolated macrophages and 60 matched pairs of breast tissue samples were subjected to the analysis. The results indicated that FRβ was overexpressed in tumor-associated macrophages (TAMs) but not epithelial cells, in addition to an enhanced level of FRα in breast cancer cells and tissue samples. Moreover, the levels of the FR isoforms were evaluated according to the histology, histopathological features and molecular subtypes of breast cancer. Several positive associations with PR/ER and HER2 status and metastasis were revealed.
Unobtrusive ambulatory EEG using a smartphone and flexible printed electrodes around the ear
Authors: Debener Stefan , Emkes Reiner , De Vos Maarten , Bleichner Martin
Published: November 2015

This study presents first evidence that reliable EEG data can be recorded with a new cEEGrid electrode array, which consists of ten electrodes printed on flexible sheet and arranged in a c-shape to fit around the ear. Ten participants wore two cEEGrid systems for at least seven hours. Using a smartphone for stimulus delivery and signal acquisition, resting EEG and auditory oddball data were collected in the morning and in the afternoon six to seven hours apart. Analysis of resting EEG data confirmed well-known spectral differences between eyes open and eyes closed conditions. The ERP results confirmed the predicted condition effects with significantly larger P300 amplitudes for target compared to standard tones and a high test-retest reliability of the P300 amplitude (r > = .74). Moreover, a linear classifier trained on data from the morning session revealed similar performance in classification accuracy for the morning and the afternoon sessions (both > 70%). These findings demonstrate the feasibility of concealed and comfortable brain activity acquisition over many hours.
Alterations in Circulating Immune Cells in Neovascular Age-Related Macular Degeneration
Authors: Lechner Judith , Chen Mei , Hogg Ruth E. , Toth Levente , Silvestri Giuliana , Chakravarthy Usha , Xu Heping
Published: November 2015

Neovascular age-related macular degeneration (nAMD) is the leading cause of irreversible blindness in developed countries. Recent advances have highlighted the essential role of inflammation in the development of the disease. In addition to local retinal chronic inflammatory response, systemic immune alterations have also been observed in AMD patients. In this study we investigated the association between the frequency of circulating leukocyte populations and the prevalence as well as clinical presentations of nAMD. Leukocyte subsets of 103 nAMD patients (most of them were receiving anti-VEGF therapy prior to enrolment) and 26 controls were analysed by flow cytometry by relative cell size, granularity and surface markers. Circulating CD11b+ cells and CD16hiHLA-DR− neutrophils were significantly increased (P = 0.015 and 0.009 respectively) in nAMD when compared to controls. The percentage of circulating CD4+ T-cells was reduced in nAMD patients without subretinal fibrosis (P = 0.026) compared to patients with subretinal fibrosis. There was no correlation between the percentage of circulating leukocytes and the responsiveness to anti-VEGF therapy in nAMD patients. Our results suggest that higher levels of circulating CD11b+ cells and neutrophils are associated with nAMD and that reduced levels of CD4+ T-cells are associated with the absence of subretinal fibrosis in nAMD.
What determines positive, neutral and negative impacts of Solidago canadensis invasion on native plant species richness?
Authors: Dong Li-Jia , Yu Hong-Wei , He Wei-Ming
Published: November 2015

Whether plant invasions pose a great threat to native plant diversity is still hotly debated due to conflicting findings. More importantly, we know little about the mechanisms of invasion impacts on native plant richness. We examined how Solidago canadensis invasion influenced native plants using data from 291 pairs of invaded and uninvaded plots covering an entire invaded range and quantified the relative contributions of climate, recipient communities and S. canadensis to invasion impacts. There were three types of invasion consequences for native plant species richness (i.e., positive, neutral and negative impacts). Overall, the relative contributions of recipient communities, S. canadensis and climate to invasion impacts were 71.39%, 21.46% and 7.15%, respectively; furthermore, the roles of recipient communities, S. canadensis and climate were largely ascribed to plant diversity, density and cover and precipitation. In terms of direct effects, invasion impacts were negatively linked to temperature and native plant communities and positively to precipitation and soil microbes. Soil microbes were crucial in the network of indirect effects on invasion impacts. These findings suggest that the characteristics of recipient communities are the most important determinants of invasion impacts and that invasion impacts may be a continuum across an entire invaded range.
Cervical intraepithelial neoplasia disease progression is associated with increased vaginal microbiome diversity
Authors: Mitra A. , MacIntyre D. A. , Lee Y. S. , Smith A. , Marchesi J. R. , Lehne B. , Bhatia R. , Lyons D. , Paraskevaidis E. , Li J. V. , Holmes E. , Nicholson J. K. , Bennett P. R. , Kyrgiou M.
Published: November 2015

Persistent infection with oncogenic Human Papillomavirus (HPV) is necessary for cervical carcinogenesis. Although evidence suggests that the vaginal microbiome plays a functional role in the persistence or regression of HPV infections, this has yet to be described in women with cervical intra-epithelial neoplasia (CIN). We hypothesised that increasing microbiome diversity is associated with increasing CIN severity. llumina MiSeq sequencing of 16S rRNA gene amplicons was used to characterise the vaginal microbiota of women with low-grade squamous intra-epithelial lesions (LSIL; n = 52), high-grade (HSIL; n = 92), invasive cervical cancer (ICC; n = 5) and healthy controls (n = 20). Hierarchical clustering analysis revealed an increased prevalence of microbiomes characterised by high-diversity and low levels of Lactobacillus spp. (community state type-CST IV) with increasing disease severity, irrespective of HPV status (Normal = 2/20,10%; LSIL = 11/52,21%; HSIL = 25/92,27%; ICC = 2/5,40%). Increasing disease severity was associated with decreasing relative abundance of Lactobacillus spp. The vaginal microbiome in HSIL was characterised by higher levels of Sneathia sanguinegens (P < 0.01), Anaerococcus tetradius (P < 0.05) and Peptostreptococcus anaerobius (P < 0.05) and lower levels of Lactobacillus jensenii (P < 0.01) compared to LSIL. Our results suggest advancing CIN disease severity is associated with increasing vaginal microbiota diversity and may be involved in regulating viral persistence and disease progression.
Chronic corticosterone-mediated dysregulation of microRNA network in prefrontal cortex of rats: relevance to depression pathophysiology
Authors: Dwivedi Y , Roy B , Lugli G , Rizavi H , Zhang H , Smalheiser N R
Published: November 2015

Stress plays a major role in inducing depression, which may arise from interplay between complex cascades of molecular and cellular events that influence gene expression leading to altered connectivity and neural plasticity. In recent years, microRNAs (miRNAs) have carved their own niche owing to their innate ability to induce disease phenotype by regulating expression of a large number of genes in a cohesive and coordinated manner. In this study, we examined whether miRNAs and associated gene networks have a role in chronic corticosterone (CORT; 50 mg kg−1 × 21 days)-mediated depression in rats. Rats given chronic CORT showed key behavioral features that resembled depression phenotype. Expression analysis revealed differential regulation of 26 miRNAs (19 upregulated, 7 downregulated) in prefrontal cortex of CORT-treated rats. Interaction between altered miRNAs and target genes showed dense interconnected molecular network, in which multiple genes were predicated to be targeted by the same miRNA. A majority of altered miRNAs showed binding sites for glucocorticoid receptor element, suggesting that there may be a common regulatory mechanism of miRNA regulation by CORT. Functional clustering of predicated target genes yielded disorders such as developmental, inflammatory and psychological that could be relevant to depression. Prediction analysis of the two most prominently affected miRNAs miR-124 and miR-218 resulted into target genes that have been shown to be associated with depression and stress-related disorders. Altogether, our study suggests miRNA-mediated novel mechanism by which chronic CORT may be involved in depression pathophysiology.
Can we observe changes in mRNA “state”? Overview of methods to study mRNA interactions with regulatory proteins relevant in cancer related processes
Authors: Zurla C. , Jung J. , Santangelo P. J.
Published: November 2015

RNA binding proteins (RBP) regulate the editing, localization, stabilization, translation, and degradation of ribonucleic acids (RNA) through their interactions with specificcis-acting elements within target RNAs.
Enhancement of cycle performance of Li–S batteries by redistribution of sulfur
Authors: Kim Kwi Ryong , Yu Seung-Ho , Sung Yung-Eun
Published: November 2015

A practically available strategy is employed to improve the cycle life of lithium–sulfur batteries.
Nanoparticles self-assembled from multiple interactions: a novel near-infrared fluorescent sensor for the detection of serum albumin in human sera and turn-on live-cell imaging
Authors: Fan Xiaopeng , He Qingyuan , Sun Shiguo , Li Hongjuan , Pei Yuxin , Xu Yongqian
Published: November 2015

A novel pyrene-conjugated squaraine fluorescence probeSQ-Pcan self-assemble into nanoparticles, selectively detect serum albumin, and be used for imaging in living cells.
Copper mediated decarboxylative direct C–H arylation of heteroarenes with benzoic acids
Authors: Patra Tuhin , Nandi Sudip , Sahoo Santosh K. , Maiti Debabrata
Published: November 2015

Copper mediated decarboxylative direct C–H arylation of 5-membered heteroarenes with aryl carboxylic acids is developed using the molecular oxygen as sole oxidant. Copper plays the dual role in decarboxylation and C–H arylation.
Double head-to-tail direct arylation as a viable strategy towards the synthesis of the aza-analog of dihydrocyclopenta[hi]aceanthrylene – an intriguing antiaromatic heterocycle
Authors: Firmansyah Dikhi , Deperasińska Irena , Vakuliuk Olena , Banasiewicz Marzena , Tasior Mariusz , Makarewicz Artur , Cyrański Michał K. , Kozankiewicz Bolesław , Gryko Daniel T.
Published: November 2015

Straightforwardly prepared head-to-tail bis-imidazo[1,2-a]pyridine displays antiaromaticity and no fluorescence.
Ab initio electronic structure study of a model water splitting dimer complex
Authors: Fernando Amendra , Aikens Christine M.
Published: November 2015

The electronic structure of a model Mn dimer is examined during the water splitting mechanism using multiconfigurational methods.
Endoplasmic reticulum targeting tumour selective photocytotoxic oxovanadium(iv) complexes having vitamin-B6 and acridinyl moieties
Authors: Banerjee Samya , Dixit Akanksha , Karande Anjali A. , Chakravarty Akhil R.
Published: November 2015

Vitamin-B6 Schiff base complexes of oxovanadium(iv) having (acridinyl)dipyridophenazine show tumor selective visible light-induced photocytotoxicity by endoplasmic reticulum targeting1O2-mediated apoptosis.
NHC carbene supported half-sandwich hydridosilyl complexes of ruthenium: the impact of supporting ligands on Si⋯H interligand interactions
Authors: Mai Van Hung , Kuzmina Lyudmila G. , Churakov Andrei V. , Korobkov Ilia , Howard Judith A. K. , Nikonov Georgii I.
Published: November 2015

Electron donating NHC carbene ligand IPr exerts stronger RuH⋯Si interactions in complexes Cp(IPr)RuH2(SiR3) than in related iPr3P complexes Cp(iPr3P)RuH2(SiR3).
An amphoteric reactivity of a mixed-valent bis(μ-oxo)dimanganese(iii,iv) complex acting as an electrophile and a nucleophile
Authors: Sankaralingam Muniyandi , Jeon So Hyun , Lee Yong-Min , Seo Mi Sook , Ohkubo Kei , Fukuzumi Shunichi , Nam Wonwoo
Published: November 2015

A mixed-valent bis(μ-oxo)dimanganese(iii,iv) complex showed an amphoteric reactivity in both electrophilic and nucleophilic oxidative reactions.
One pot synthesis of environmentally friendly lignin nanoparticles with compressed liquid carbon dioxide as an antisolvent
Authors: Myint Aye Aye , Lee Hun Wook , Seo Bumjoon , Son Won-Su , Yoon Junho , Yoon Tae Jun , Park Hee Jeong , Yu Jihyun , Yoon Jeyong , Lee Youn-Woo
Published: November 2015

Lignin nanoparticles of uniform, small quasi-spherical shape with a relatively high BET surface area (nearly 92 m2g−1) were synthesized using a facile, one pot technology of a compressed CO2antisolvent.
An efficient route to regioselective functionalization of benzo[b]thiophenes via palladium-catalyzed decarboxylative Heck coupling reactions: insights from experiment and computation
Authors: Yang Daoshan , Liu Yuxia , Sun Pengfei , Zhang Ning , Wei Wei , Sun Mingyang , Chen Guang , Bi Siwei , Wang Hua
Published: November 2015

This study reports the Pd-catalyzed decarboxylative Heck-type coupling of 3-chlorobenzo[b]thiophene-2-carboxylic acids with styrenes.
Zn/Sc bimetallic relay catalysis: one pot cycloisomerization/carbonyl–ene reaction toward oxazole derivatives
Authors: Wang Bin , Chen Ying , Zhou Ling , Wang Jianwu , Xu Zhenghu
Published: November 2015

A novel tandem metal relay catalytic system combining Zn(ii)-catalyzed cycloisomerization and a Sc(iii)-catalyzed carbonyl–ene reaction has been successfully developed.
Solution synthesis protocols for shaping mixed valent oxide crystalline particles as robust catalytic materials
Authors: Yu Jing-Wen , Zhu Wei , Zhang Ya-Wen
Published: November 2015

Recent progress in the solution based shape controlled synthesis of several typical mixed valent oxides which have been used as highly efficient catalytic nanomaterials in some heterogeneous and photocatalytic reactions has been reviewed.
Multivariate statistical analysis methods in QSAR
Authors: Pirhadi Somayeh , Shiri Fereshteh , Ghasemi Jahan B.
Published: November 2015

The emphasis of this review is particularly on multivariate statistical methods currently used in quantitative structure–activity relationship (QSAR) studies.
Towards understanding KOH conditioning of amidoxime-based polymer adsorbents for sequestering uranium from seawater
Authors: Pan Horng-Bin , Kuo Li-Jung , Wood Jordana , Strivens Jonathan , Gill Gary A. , Janke Christopher J. , Wai Chien M.
Published: November 2015

Utilizing spectroscopic and microscopic techniques to understand the KOH conditioning process required for preparing high-surface-area amidoxime-based polymer fiber adsorbents for sequestering uranium from real seawater.
Jones-Ray effect on the organization of lysozyme in the presence of NaNO3 at an air/water interface: is it a cause or consequence?
Authors: Jaganathan Maheshkumar , Dhathathreyan Aruna , Selvaraju Chellappan , Miller Reinhard
Published: November 2015

Interfacial rheology confirms the Jones-Ray effect resulting from a synergy between lysozyme and NaNO3 at an air/fluid interface.
Nano Ru catalysts supported on carbon nanotubes for cellobiose conversion to sugar alcohols: effects of CNT channel size
Authors: Ran Maofei , Chu Wei , Liu Yan , Borgna Armando
Published: November 2015

The catalytic activity of a Ru/CNT-in sample was enhanced with the decrease of the CNT inner diameter and it was much higher than that of Ru/CNTs-out.
Highly dispersed cobalt oxide nanoparticles on CMK-3 for selective oxidation of benzyl alcohol
Authors: Yang Xiaoyuan , Wu Shujie , Peng Ling , Hu Jing , Wang Xiufang , Fu Xiaoran , Huo Qisheng , Guan Jingqi
Published: November 2015

Nano cobalt oxide particles supported on ordered mesoporous carbon CMK-3 (CMK: carbon material from Korea) were prepared by a hydrothermal synthesis method.
Ion implantation of low energy Si into graphene: insight from computational studies
Authors: Li Weisen , Xue Jianming
Published: November 2015

Computational study shows that high efficient Si doping in graphene was achieved from low-energy Si ion implantation.
Rapid and non-invasive diagnosis of coronary artery disease via clinical laboratory parameters and1H-NMR spectra of human blood plasma
Authors: Shahbazy Mohammad , Zahraei Ali , Vafaeimanesh Jamshid , Kompany-Zareh Mohsen
Published: November 2015

Coronary artery disease (CAD), one of the most common fatal diseases in the world, was examinedviainvestigation of the1H-NMR spectra of human blood plasma and clinical laboratory parameters with the aim of early disease diagnosis.
Refractometric and colorimetric index sensing by a plasmon-coupled hybrid AAO nanotemplate
Authors: Bae Kyuyoung , Lee Jungmin , Kang Gumin , Yoo Do-Sik , Lee Chang-Won , Kim Kyoungsik
Published: November 2015

A highly versatile and low-cost large-area refractive index sensor capable of refractometric and colorimetric sensing was developed using a plasmon-coupled hybrid nanotemplate of anodic aluminum oxide with a deposited gold nanosurface.
Metal-free TBHP-mediated oxidative ring openings of 2-arylimidazopyridines via regioselective cleavage of C–C and C–N bonds
Authors: Yan Kelu , Yang Daoshan , Wei Wei , Li Guoqing , Sun Mingyang , Zhang Qingyun , Tian Laijin , Wang Hua
Published: November 2015

A highly regioselective TBHP-mediated ring opening of imidazopyridinesviacleavage of C–C and C–N bonds has been realized for the first time to afford usefulN-(pyridin-2-yl)benzamides under mild conditions.
Vinyl benzoxazine: a novel heterobifunctional monomer that can undergo both free radical polymerization and cationic ring-opening polymerization
Authors: Ma He-Ming , Liu Yun , Liu Ying-Xuan , Qiu Jin-Jun , Liu Cheng-Mei
Published: November 2015

A novel heterobifunctional monomer (6-ethenyl-3-phenyl-3,4-dihydro-2H-1,3-benzoxazine (VBOZO)) containing both a vinyl group and benzoxazine group was successfully prepared and the homo- and copolymerization reactions of this monomer were studied.
Anchorage of a ruthenium complex into modified MOF: synergistic effects for selective oxidation of aromatic and heteroaromatic compounds
Authors: Tabatabaeian Khalil , Zanjanchi Mohammad Ali , Mahmoodi Nosrat. O. , Eftekhari Tooraj
Published: November 2015

The structure of IRMOF-3 was modified with pyridine-2-aldehyde and then the Schiff base moieties were used to anchor ruthenium complex to this metal–organic framework.
A host–guest complexation based fluorescent probe for the detection of paraquat and diquat herbicides in aqueous solutions
Authors: Song Gui-Xian , Tang Qing , Huang Ying , Wang Ruibing , Xi Yun-Yun , Ni Xin-Long , Tao Zhu , Xue Sai-Feng , Zhang Jian-Xin
Published: November 2015

A new method based on fluorescence quenching of host–guest complexation was proposed for the determination of the two herbicides in river water and cabbages. The method is rapid, direct and simple.
Harmonization of upconverting nanocrystals and photosensitizer for antimicrobial application
Authors: Tree-Udom Thapakorn , Thamyongkit Patchanita , Wiratkasem Nawaporn , Chanchao Chanpen , Palaga Tanapat , Insin Numpon , Rengpipat Sirirat , Pienpinijtham Prompong , Wanichwecharungruang Supason
Published: November 2015

Effective anti-P. acnesusing near infrared light is made possible by perfecting the matching between absorption wavelengths of the loaded photosensitizer and emission wavelengths of the upconverting nanoparticles with high UVA/visible emissions.
Growth of novel boron-rich nanocrystals from oxygen-deficient borophosphosilicate glasses for boron neutron capture therapy
Authors: Sugimoto H. , Imakita K. , Fujii M.
Published: November 2015

We develop a new type of boron-rich nanocrystals, which are dispersible in water and exhibit photoluminescence in the biological window, can be a multifunctional biomaterial used for imaging, diagnosis and boron neutron capture therapy.
Drug-loaded emulsion electrospun nanofibers: characterization, drug release and in vitro biocompatibility
Authors: Hu Jue , Prabhakaran Molamma P. , Tian Lingling , Ding Xin , Ramakrishna Seeram
Published: November 2015

Emulsion electrospun drug–PCL nanofibrous mats were demonstrated as better drug delivery substrates and tissue engineering scaffold compared to PHBV nanofibers.
Spectroscopic chemical insights leading to the design of versatile sustainable composites for enhanced marine application
Authors: Dzielendziak Agnieszka S. , Blake James I. R. , Bounds Richard , Wilkinson Karl A. , Carravetta Marina , Chambers Alan R. , Skylaris Chris-Kriton , Raja Robert
Published: November 2015

A versatile strategy for the design of sustainable polymer composites, based on photo-cured linseed oil resin, offers attractive prospects for the marine industry.
A graphene/hemin hybrid material as an efficient green catalyst for stereoselective olefination of aldehydes
Authors: Joshi Chetan , Kumar Pawan , Behera Babita , Barras Alexandre , Szunerits Sabine , Boukherroub Rabah , Jain Suman L.
Published: November 2015

A hemin/graphene composite was investigated for olefination of aldehydes using ethyl diazoacetate in the presence of triphenylphosphine.
Synthesis and characterization of photoresponsive POSS-based polymers and their switchable water and oil wettability on cotton fabric
Authors: Huang Jianbao , Huang Yangen , He Chuanglong , Gao Yu
Published: November 2015

Photoresponsive POSS-based polymers were successfully prepared via radical polymerization. The surface wettability of both water and oil on the polymers coated fabrics can be intelligently controlled by applying irradiation with UV or visible light.
Effect of different clay minerals and calcination temperature on the morphology and color of clay/CoAl2O4 hybrid pigments
Authors: Mu Bin , Wang Qin , Wang Aiqin
Published: November 2015

Clay/CoAl2O4 hybrid pigments with different morphologies and colors have been successfully fabricated by combining the coprecipitation technique and a successive calcination step.
Graphene oxide-based polymeric membranes for broad water pollutant removal
Authors: Zhang Xiang , Liu Ying , Sun Chuangchao , Ji Haifeng , Zhao Weifeng , Sun Shudong , Zhao Changsheng
Published: November 2015

Three kinds of GO-based polymeric membranes with specific adsorption characteristics were fabricated by a facile blending method; the prepared membranes showed good adsorption capacities and selectivity for the difficult types of water contaminants.
In situ monitoring of palladacycle-mediated carbonylation by surface-enhanced Raman spectroscopy
Authors: Hu Kai , Li Da-Wei , Cui Jing , Cao Yue , Long Yi-Tao
Published: November 2015

A novel surface-enhanced Raman spectroscopy (SERS) based strategy for the in situ monitoring of palladacycle-mediated carbonylation.
Tunable macro–mesoporous ZnO nanostructures for highly sensitive ethanol and acetone gas sensors
Authors: Huang Hua-Wen , Liu Jing , He Guangfu , Peng Yao , Wu Min , Zheng Wei-Hong , Chen Li-Hua , Li Yu , Su Bao-Lian
Published: November 2015

Macro–mesoporous ZnO nanostructures with a wurtzite hexagonal structure have been successfully synthesized using polymer colloids and ZnO nanoparticles, and exhibit excellent gas sensing performances.
Comprehensive investigation of the reciprocity of structure and enhanced photocatalytic performance in finned-tube structured TiO2/BiOBr heterojunctions
Authors: Xue Chao , Xu Xin , Yang Guidong , Ding Shujiang
Published: November 2015

The formation mechanism of the as-prepared 1D finned-tube structured TiO2@BiOBr heterojunctions and a possible mechanism of the photocatalytic activity enhancement were proposed.
A new oxidation system for the oxidation of Hantzsch-1,4-dihydropyridines and polyhydroquinoline derivatives under mild conditions
Authors: Bai Cui-Bing , Wang Nai-Xing , Wang Yan-Jing , Lan Xing-Wang , Xing Yalan , Wen Jia-Long
Published: November 2015

An oxidation system to synthesize pyridine derivatives has been developed by oxidation of 1,4-dihydropyridines and polyhydroquinoline derivatives in good yields.
In situ gel-forming dual drug delivery system for synergistic combination therapy of colorectal peritoneal carcinomatosis
Authors: Li Xiaoling , Fan Rangrang , Wang Yuelong , Wu Min , Tong Aiping , Shi Juan , Xiang Mingli , Zhou Liangxue , Guo Gang
Published: November 2015

A novel local drug delivery system composed of docetaxel loaded micelles and an oxaliplatin loaded hydrogel was fabricated and proved to be potentially useful in the treatment of colorectal peritoneal carcinomatosis.
Synthesis and diverse general oxidative cyclization catalysis of high-valent MoVIO2(HL) to ubiquitous heterocycles and their chiral analogues with high selectivity
Authors: Pramanik Nabyendu , Sarkar Satinath , Roy Dipanwita , Debnath Sudipto , Ghosh Sukla , Khamarui Saikat , Maiti Dilip K.
Published: November 2015

The first synthesis and diverse oxidative cyclization catalysis properties of high-valent MoVI–triazole are demonstrated towards highly selective construction of benzimidazoles, benzothiazoles, isoxazolines, isoxazoles and their chiral analogues.
Indium recovery from waste liquid crystal displays by polyvinyl chloride waste
Authors: Guan Jie , Wang Shuai , Ren Haohua , Guo Yaoguang , Yuan Hao , Yan Xingru , Guo Jiang , Gu Weixing , Su Ruijing , Liang Bo , Gao Guilan , Zhou Yuan , Xu Jinqiu , Guo Zhanhu
Published: November 2015

An efficient recovery of high purity indium from waste LCDs was achieved via PVC waste.
Selenium-containing thermogel for controlled drug delivery by coordination competition
Authors: Luan Jiabin , Shen Wenjia , Chen Chang , Lei Kewen , Yu Lin , Ding Jiandong
Published: November 2015

A coordination-responsive selenium-containing thermogel was designed and synthesized for controlled cisplatin delivery by competitive coordination of glutathione, which broadens the strategy of tuning drug release using thermogelling systems.
Smallest deltahedra silicon dicarbide: C2Si32−
Authors: Sui Jing-jing , Xu Jing , Ding Yi-hong
Published: November 2015

In this paper, we reported the smallest main-group dicarbide with all deltahedras, which is also the first main-group dicarbide with (n+ 1) polyhedral skeletal electron pairs (PSEPs).
Self-sacrifice Te template synthesis of new phase PbmSb2nTem+3n nanorods via Pb2+/Sb3+ synergistic effect
Authors: Su Ziming , Wang Qun , Li Jianhuan , Zhang Guangjun
Published: November 2015

New phase PbmSb2nTem+3n nanorods were synthesized using Te self-sacrifice template via Pb2+/Sb3+ synergistic effect topotactic transformation, which showed bigger band gap values due to the quantum confinement effect.