bluuebunny/crossref_metadata_2025 huggingface dataset:
Differential activation of NLRP3 inflammasome by Acinetobacter baumannii strains
Authors: Li Fei-Ju , Starrs Lora , Mathur Anukriti , Ishii Hikari , Man Si Ming , Burgio Gaetan
Published: November 2022

Acinetobacter baumanniiis an emerging nosocomial, opportunistic pathogen with growing clinical significance globally.A.baumanniihas an exceptional ability to rapidly develop drug resistance. It is frequently responsible for ventilator-associated pneumonia in clinical settings and inflammation resulting in severe sepsis. The inflammatory response is mediated by host pattern-recognition receptors and the inflammasomes. Inflammasome activation triggers inflammatory responses, including the secretion of the pro-inflammatory cytokines IL-1β and IL-18, the recruitment of innate immune effectors againstA.baumanniiinfection, and the induction programmed cell death by pyroptosis. An important knowledge gap is how variation among clinical isolates affects the host’s innate response and activation of the inflammasome duringA.baumanniiinfection. In this study, we compared nineA.baumanniistrains, including clinical locally-acquired isolates, in their ability to induce activation of the inflammasome and programmed cell death in primary macrophages, epithelial lung cell line and mice. We found a variation in survival outcomes of mice and bacterial dissemination in organs among three commercially availableA.baumanniistrains, likely due to the differences in virulence between strains. Interestingly, we found variability amongA.baumanniistrains in activation of the NLRP3 inflammasome, non-canonical Caspase-11 pathway, plasmatic secretion of the pro-inflammatory cytokine IL-1β and programmed cell death. Our study highlights the importance of utilising multiple bacterial strains and clinical isolates with different virulence to investigate the innate immune response toA.baumanniiinfection.
Adult-onset Leigh syndrome due to m.9176T>C mutation with cortical involvement
Authors: Lee Hyuk-je , Lee Myungah , Lee Jung Hwan
Published: November 2022

We describe the case of a 22-year-old female complaining of ophthalmoplegia, which deteriorated with seizure. Leigh syndrome (LS) was diagnosed by identifying the m.9176T>C mutation. She improved with vitamin cocktail therapy plus intravenous methylprednisolone, and had an excellent prognosis. This was the first case of an adult patient with LS presenting with the m.9176T>C mutation and reporting cortical symptoms, which in this case comprised cortical vision loss, and cortical, basal ganglia, and brainstem signal changes on magnetic resonance imaging.
Centro Brasileiro de Informação sobre Medicamentos - 30 anos de promoção do uso racional de medicamentos
Authors: Leite Leticia Nogueira , Porcino Rayssa Aragão , Hoefler Rogério
Published: November 2022

Edição comemorativa 30 anos Cebrim/CFF
A Model Approach to Understanding Monetary Aggregates Growth in Sierra Leone and Implications for Policy Formulation
Authors: JACKSON Emerson Abraham , VANDY Patricia Sarah
Published: November 2022

This study has adopted a model approach to developing an understanding of monetary aggregates (MA) growth in Sierra Leone, which certainly has implications for effective policy formulation by the central bank authority. In pursuance of this, we utilized the Autoregressive Moving Average (ARIMA) model with data spanning 2002M1 to 2021M12 to investigate the out-of-sample projection performance of the disaggregated components that makes up the MA for Sierra Leone – typically in this case Reserve Money (RMA), Currency-in-Circulation (CiC) and Reserve Money (RM). In our evidence from the empirical projection (covering the period 2022M1-2022M12), we observed that RM is projected to grow more than CiC over the observed period. Given RM being the operational target of the Bank of Sierra Leone, we believe that such an outcome is a promising indication particularly in ensuring the bank addresses its core mandates of monitoring price and financial stability. The increased scope of RM in the BSL system is a laudable outcome when it comes to meeting reserve requirements and also managing risks about price and financial stability. The study recommends that the BSL adopt innovation strategies concerned with FinTech and the emergence of the National Switch to effectively manage the MA portfolio in the entire banking system, which will also support the overall growth ambition of the central government.
Gestión pública o privada de las universidades: ¿Cuál es la opción más eficiente para una política pública en educación superior en Colombia?
Authors: Morales-Piñero Juan , Niño-Muñoz Diana , Lesmes-Cardenas Diana
Published: November 2022

El Estado se conoce como el garante del servicio de educación superior. Sin embargo, este no siempre tiene la capacidad operativa para garantizar una adecuada cobertura en la prestación del servicio, y por ello delega en actores públicos y privados esta responsabilidad, so pena de comprometer la calidad del mismo. En este sentido, el objetivo de este artículo es comparar, a partir de una medición holística, la eficiencia entre la gestión pública y la privada de las universidades colombianas para orientar la formulación de políticas públicas en educación superior. Es así como se estimó una metafrontera de eficiencia utilizando el análisis envolvente de datos (DEA, por sus siglas en inglés), que incluye el desempleo formal como variable de bad output, para recoger información acerca del efecto no deseado en la prestación de servicio de las 122 universidades analizadas. Aunque no fue posible comprobar diferencias significativas entre la gestión pública y la privada de las universidades, sí se pudieron evidenciar escenarios donde la política pública puede ayudar a mejorar el desempeño del sistema, atendiendo diferencias por el tipo de propiedad y la ubicación geográfica. Dentro de las conclusiones principales se destaca la importancia de las particularidades regionales para consolidar de manera selectiva las asociaciones público-privadas y mejorar el desempeño del sistema en su conjunto.
QUO VADIS PENEGAKAN HUKUM POLITIK UANG: POTRET PILKADA SERENTAK 2020 DI PROVINSI JAWA TENGAH
Authors: Diamantina Amalia , ALW Lita Tyesta
Published: November 2022

Pilkada 2020 di Provinsi Jawa Tengah menyisakan persoalan politik uang. Namun, setelah ditangani Sentra Penegakan Hukum Terpadu, kasusnya tidak dapat dilanjut ke tahap penyidikan karena kekurangan bukti, tidak memenuhi unsur pasal yang disangkakan, dan sudah daluwarsa. Penelitian ini membahas persoalan penegakan hukum politik uang oleh Bawaslu dengan menggunakan pendekatan yuridis normatif dan mengandalkan data sekunder. Penegakan hukum politik uang Pilkada 2020 belum optimal karena dari segi substansi hukum, terdapat sanksi pidana yang menjerat penerima sehingga masyarakat enggan melaporkan, batas waktu penanganan yang terbatas, justifikasi dan beban pembuktian yang sulit, serta batasan pengecualian politik uang yang tidak ditentukan secara konkret. Bawaslu sebagai penegak hukum tidak memiliki kewenangan memanggil paksa pihak yang terlibat serta kultur masyarakat yang memandang politik uang sebagai hal biasa.
Status-Quo dan Inovasi: Respon Strategis Badan Usaha Milik Desa Menghadapi Krisis Pandemik Covid-19
Authors: Martanto Ucu , Pramutanto Wisnu , Muzaqqi Fahrul , Wijayanto Febby Risti , Fitrianto Hari , Windyastuti Dwi , Candland Christopher
Published: November 2022

Keberadaan Badan Usaha Milik Desa (BUM Desa) di Jawa Timur telah menjelma menjadi lembaga sosial ekonomi yang turut berkontribusi meningkatkan kesejahteraan masyarakat desa. Namun krisis pandemik Covid-19 telah menghantam hampir seluruh kegiatan bisnis BUM Desa. Dalam kajian managemen krisis organisasi, pilihan-pilihan respon strategis saat krisis berperan signifikan dalam proses adaptasi dan pemulihan pasca krisis. Penelitian kualitatif ini mengungkap spektrum pertimbangan pilihan utama respon strategis BUM Desa dalam menghadapi krisis. Analisis atas data wawancara semi-terstruktur pemangku kepentingan menunjukan sebagian besar BUM Desa memilih tetap menjalankan bisinisnya (status quo) meskipun merugi. Temuan penelitian ini berbeda dengan pilihan respon strategis perusahaan swasta dan perusahaan negara dalam menghadapi krisis yang lebih memilih berhemat dan berinovasi. Penilaian atas opsi respon strategis menjadi asupan pemerintah daerah merumuskan kebijakan pemulihan BUM Desa pasca krisis.
Voter Behaviour and The Campaign Pattern of Candidates during Pandemics in Regional Head Election in Medan City, North Sumatra
Authors: Fauzan Indra
Published: November 2022

Covid-19 has influenced the process of democracy in many countries, including Indonesia, especially in the local election. The political campaign involving mass mobilisation was restricted, so the candidates were encouraged to use online media to reduce the Covid-19 spread. Based on this problem, this study aims to analyse the campaign patterns between candidates in a regional head election in Medan during a pandemic and how the candidates increase voter turnout. This study used both the qualitative method by interviewing the campaign team of the candidates in charge of online and offline media and the quantitative method by distributing the questionnaires to measure the behaviour of the voters. This study showed that the perception of popularity and electability influenced the pattern of candidate campaigns, and the low political awareness of the community influenced low participation in political campaigns and voter turnout, besides unhealthy campaigns and negative perception of local government. Therefore, although face-to-face was restricted, the candidates believed that direct meetings with the voters were only the way to influence the voter and increase political participation.
Integrating Social Values: Evidence from The Intermediary Institution in Indonesian Elections
Authors: Tawakkal George Towar Ikbal
Published: November 2022

Many scholars called the intermediary institutions in elections as vote brokers. As a consequence of that, then they built an argument based on a transactional framework, especially about the motivation of the institution. On the other side, they agreed that vote brokerage was built based on a social network, especially when they tried to define the vote brokerage. It means, the intermediary institution occurred in social interactions. That is weird for explaining social interactions without considering other social values. It looks like social interaction is only about material value. Other scholars tried to be fairness by calling the intermediary as middlemen, but still very few literature built the argument based on a non-transactional framework. This study will certainly provide new insights into the intermediary institution studies, particularly related to the understanding of non-transactional amid transactional arguments that have been shown in many kinds of literature, as well as expanding the study of intermediary institutions which likely to focused on providing voters, to be focused on the establishment of intermediary institutions. We conducted a series of in-depth interviews with 45 people consisting of persons in the intermediary institutions, political party leaders, leaders of campaign teams, election organizers, and more than a hundred voters during 2017 – 2019 in Indonesian elections, consists of four Villages head elections, 2018 Governor election, and 2019 legislative elections. We found the transactional logic or material value was not the only one, even mostly was not the dominant value that generated the intermediary institutions.
Improvement of oil content in groundnut (Arachis hypogaea L.) by the impacts of gamma irradiation
Authors: Aswini G , Arulbalachandran D , Latha S , Selvakumar G
Published: November 2022

Gamma radiation dosages of 100, 200, 300, 400, 500 and 600 Gy were given to the groundnut seed variety Dharani (Arachis hypogaea L.). The study's goal was to look at genetic diversity, heritability and genetic advancement for seed yield and quality characteristics in M2 generation using only a Randomized Complete Block Experiment using 3 replications from 2018 to 2019. The article's outcomes significantly enhanced the oil content of groundnut at 400 Gy to 52.44 % as compared to other dosages. For all characteristics, treated seeds displayed more variance than control seeds, particularly seed yield per plant showing the highest in GCV, PCV, H2, GA and GAM. In most traits, 400 Gy of gamma-ray treatment generates the largest changes however, 600 Gy of gamma-ray treatment also creates equivalent conditions. The link between features demonstrated that the number of pods per plant had a significant role in rationalizing seed yield variance in the M2 generation. These findings show that this yield component is one of the most important predictors of pod yield variations among plants and it is also favorably impacted by irradiation mutagens (gamma rays).
Changes in the proverb formula in Finnish Bibles from 1642 to 1992
Authors: Priiki Katri
Published: November 2022

The article studies a subtype of the Finnish generalizing relative clause, referred to as the proverb formula. A generalizing relative clause refers to any person who fills the described condition. The proverb formula is used frequently in the Finnish translations of the Bible in the Book of Proverbs. The study examines two aspects that vary in this structure in Finnish editions from 1642 to 1992: the head pronoun of the relative clause and the order of the relative clause and the main clause. In the oldest of the studied translations, the most frequent one variant or the proverb formula begins with the relative clause, and the relative clause head in the main clause is a personal pronoun (hän). For the order of the structure, a clear model is found in the source texts of the translation. In later editions, personal pronoun heads were eliminated. Interestingly, they are not replaced with demonstrative heads, which would follow the most frequent proverb formula structure in Finnish vernacular and would also be recommenced by grammar guides. Instead, a variant with omission of the head pronoun gains in frequency. Variations within the proverb formula increase when the order with the main clause preceding the relative clause gains in frequency. The preference for omission of the head pronouns is not easily explainable. The article proposes that this variant was a conscious stylistic choice for solemn, biblical language.
Impact on neonatal morbidities after a change in policy to administer antenatal corticosteroids to mothers at risk for late preterm delivery
Authors: Mally Pradeep , Katz Julia , Verma Sourabh , Purrier Sheryl , Wachtel Elena V. , Trillo Rebecca , Bhutada Kiran , Bailey Sean M.
Published: November 2022

Objectives

Antenatal corticosteroids (ACS) administered to mothers at risk for preterm delivery before 34 weeks has been standard care to improve neonatal outcomes. After introducing a new obstetric policy based on updated recommendations advising the administration of ACS to pregnant women at risk for late preterm (LPT) delivery (34–36 6/7 weeks), we set out to determine the short-term clinical impact on those LPT neonates.

Methods

Retrospective chart review of LPT neonates delivered at NYU Langone Medical Center both one year before and after the policy went into place. We excluded subjects born to mothers with pre-gestational diabetes, multiple gestations, and those with congenital/genetic abnormalities. We also excluded subjects whose mothers already received ACS previously in pregnancy. Subjects were divided into pre-policy and post-policy groups. Neonatal and maternal data were compared for both groups.

Results

388 subjects; 180 in the pre-policy and 208 in the post-policy group. This policy change resulted in a significant increase in ACS administration to mothers who delivered LPT neonates (67.3 vs. 20.6%, p<0.001). In turn, there was a significant reduction in LPT neonatal intensive care unit (NICU) admissions (44.2 vs. 54.4%, p=0.04) and need for respiratory support (27.9 vs. 42.8%, p<0.01). However, we also found an increased incidence of hypoglycemia (49.5 vs. 28.3%, p<0.001).

Conclusions

This LPT ACS policy appears effective in reducing the need for LPT NICU level care overall. However, clinicians must be attentive to monitor for adverse effects like hypoglycemia, and there remains a need for better understanding of potential long-term impacts.
Parameter least-squares estimation for time-inhomogeneous Ornstein–Uhlenbeck process
Authors: Pramesti Getut
Published: November 2022

We address the least-squares estimation of the drift coefficient parameter

θ
=

(
λ
,
A
,
B
,

ω
p

)

\theta=(\lambda,A,B,\omega_{p})

of a time-inhomogeneous Ornstein–Uhlenbeck process that is observed at high frequency, in which the discretized step size ℎ satisfies

h
→
0

h\to 0

.
In this paper, under the conditions

n
⁢
h

→
∞

nh\to\infty

and

n
⁢

h
2

→
0

nh^{2}\to 0

, we prove the consistency and the asymptotic normality of the estimators.
We obtain the convergence of the parameters at rate

n
⁢
h

\sqrt{nh}

, except for

ω
p

\omega_{p}

at

n
3

⁢

h
3

\sqrt{n^{3}h^{3}}

.
To verify our theoretical findings, we do a simulation study.
We then illustrate the use of the proposed model in fitting the energy use of light fixtures in one Belgium household and the stock exchange.
ARQUITETURA ESCOLAR E EDUCAÇÃO DO/NO CAMPO
Authors: Fazzioni Gabriela Maria , Lazzarotto Modler Nébora
Published: November 2022

A proposta de ensino designada como Educação do Campo, surgiu a partir de um contexto de reivindicação social, a fim de elaborar uma educação mais justa aos povos camponeses, que respeite e esteja sintonizada com seu modo de vida, sua cultura e o trabalho. A partir desse cenário e buscando a aplicação dessas premissas na arquitetura escolar, o artigo apresenta os fundamentos, as diretrizes e o projeto arquitetônico de uma escola do campo no município de Concórdia/SC, desenvolvido como Trabalho Final de Graduação do Curso de Arquitetura e Urbanismo da Universidade Federal da Fronteira Sul, Campus Erechim/RS.
ASSOCIAÇÕES SIMBÓLICAS E AFETIVAS DOS MORADORES COM A PAISAGEM DA CIDADE PEQUENA
Authors: Fogaça Cuti Auriele , Naoumova Natalia
Published: November 2022

Os moradores de uma cidade pequena vivenciam o ambiente urbano e convivem com todas as suas características. Diante disso, desenvolvem associações simbólicas e afetivas relacionadas à paisagem, somando expectativas, experiências e memórias. Conhecer como os moradores avaliam e percebem os aspectos simbólicos, bem como se isso interfere na satisfação, é um passo para entender como as pessoas se relacionam com o lugar. Foi realizado um estudo de caso, com abordagem qualitativa e quantitativa, em duas cidades do interior do Rio Grande do Sul, Brasil: Nova Palma e Silveira Martins. A amostra incluiu 131 moradores que responderam questionários e mapas mentais. A identificação com a cidade, seja ela social, cultural ou com o ambiente físico, contribuiu para as relações afetivas e associações simbólicas. De modo geral, os moradores avaliaram positivamente as suas cidades e o fato delas serem pequenas e isso agrega características que contribuem na satisfação com o lugar.
COMPLEXO JOSÉ PEDRO VARELA
Authors: Ritter Carolina , Castro Gonsales Célia
Published: November 2022

O objetivo deste artigo é analisar o projeto e observar a vida em comunidade nos espaços da Zona 1 do Complexo Habitacional José Pedro Varela (Montevidéu/Uruguai). A abordagem metodológica deste estudo possui dois enfoques: a análise do projeto e a observação da realidade, aproximando esses resultados com a crítica arquitetônica e urbanística em relação aos preceitos mais universalistas e ideológicos do Movimento Moderno, crítica protagonizada por um grupo chamado Team 10. Observou-se que, além do sistema cooperativo possibilitar uma primeira aproximação a esse contexto teórico, também a arquitetura e o urbanismo do conjunto possuem uma intenção de gerar uma qualidade de vida melhor aos seus moradores e uma vida urbana e coletiva mais efetiva. Um conjunto habitacional, embora inserido no contexto e na interface de uma grande cidade, configura de certa maneira uma vida baseada em relações quase tradicionais, mais próprias de povoados ou urbanizações menores – comunidades.
@ CAPITAL
Authors: Fuão Fernando
Published: November 2022

Esse ensaio desloca as ideias da Pedagogia do oprimido de Paulo Freire para o campo da arquitetura, sob a forma de questionamento à pedagogia que é aplicada até hoje nas Faculdades de arquitetura – que aqui chamarei de Pedagogia da arquitetura bancária – comprometendo-a com a formação dos arquitetos e urbanistas e as decorrentes implicações sociais e questionando como o professor arquiteto tem desempenhado o papel de opressor-oprimido. Costuma-se pensar a Pedagogia do oprimido como uma metodologia que é preferencialmente aplicada aos processos de alfabetização de trabalhadores, esquecendo-se que a pedagogia do oprimido é para todos os âmbitos da educação, para todos e principalmente para os próprios educadores. O artigo @ capital é subcapítulo de um texto maior: A arquitetura da pedagogia bancária, onde se desconstrói o sentido da capital através da linguagem, desnudando a palavra capital (cap), e expondo os pré-conceitos e as oposições entre capital x cidades do interior, centro x periferia, Europa e terceiro mundo; estando esses sentidos completamente comprometidos com a questão da pedagogia bancária na arquitetura e urbanismo.
Functional Intraregional and Interregional Heterogeneity between Myenteric Glial Cells of the Colon and Duodenum in Mice
Authors: Seguella Luisa , McClain Jonathon L. , Esposito Giuseppe , Gulbransen Brian D.
Published: November 2022

Enteric glia are a unique population of peripheral neuroglia that regulate homeostasis in the enteric nervous system (ENS) and intestinal functions. Despite existing in functionally diverse regions of the gastrointestinal tract, enteric glia have been approached scientifically as a homogeneous group of cells. This assumption is at odds with the functional specializations of gastrointestinal organs and recent data suggesting glial heterogeneity in the brain and ENS. Here, we used calcium imaging in transgenic mice of both sexes expressing genetically encoded calcium sensors in enteric glia and conducted contractility studies to investigate functional diversity among myenteric glia in two functionally distinct intestinal organs: the duodenum and the colon. Our data show that myenteric glia exhibit regionally distinct responses to neuromodulators that require intercellular communication with neurons to differing extents in the duodenum and colon. Glia regulate intestinal contractility in a region-specific and pathway-specific manner, which suggests regionally diverse engagement of enteric glia in local motor patterns through discrete signaling pathways. Further, functional response profiles delineate four unique subpopulations among myenteric glia that are differentially distributed between the colon and duodenum. Our findings support the conclusion that myenteric glia exhibit both intraregional and interregional heterogeneity that contributes to region-specific mechanisms that regulate digestive functions. Glial heterogeneity adds an unexpected layer of complexity in peripheral neurocircuits, and understanding the specific functions of specialized glial subtypes will provide new insight into ENS physiology and pathophysiology.

SIGNIFICANCE STATEMENTEnteric glia modulate gastrointestinal functions through intercellular communication with enteric neurons. Whether heterogeneity exists among neuron–glia interactions in the digestive tract is not understood. Here, we show that myenteric glia display regional heterogeneity in their responses to neuromodulators in the duodenum and the colon, which are functionally distinct organs. Glial-mediated control of intestinal motility is region and pathway specific. Four myenteric glial subtypes are present within a given gut region that are differently distributed between gut regions. These data provide functional and regional insights into enteric circuit specificity in the adult enteric nervous system.
Archaeology in a New Light
Authors: Opishinski Ana C. , Luiz Jade W.
Published: November 2022

Plimoth Patuxet Museums is known for its living history sites depicting the seventeenth-century Pilgrim settlement of Plymouth and the Wampanoag settlement of Patuxet. With the 400th anniversary of Mayflower’s arrival, the museum recommitted itself to presenting archaeology. Because of the challenges of publicly interpreting archaeology, the broad swath of time covered by archaeology, and the reality that most guests know little about either Indigenous history or archaeology, integrating archaeological programming into the living history format proved challenging, exacerbated by the COVID-19 pandemic. By employing a multipronged physical and digital approach, the authors have found some success in bringing a more nuanced understanding of archaeology to the institution’s stakeholders.
Learning Interest in Stie Semarang Accounting Students During Covid 19 Pandemic
Authors: Nindhita Yoga , Subekti Heni , Musfiyana Risma , Lestari Sri
Published: November 2022

This study aims to determine whether online learning, Educational Technology carried out by lecturers at STIE can increase student interest in learning about effective subjects. The population in this study were accounting students at the Sekolah Tinggi Ilmu Ekonomi Semarang, 126 Students, and 40 samples were obtained using a purposive sampling technique. The method used in this research is multiple regression analysis. The results of this study indicate that online learning has no significant effect on learning interest. Meanwhile, education technology has a significant effect on interest in learning. The value of the determinant coefficient obtained is 0.336, meaning that 33.6% of learning interest is influenced by online learning and educational technology. For future research, it is recommended to add other independent variables such as online learning methods, information technology and online learning media to complement this research further because there are other independent variables outside of this study that might affect interest in learning. Students are expected to maintain good learning. Hopefully, educational technology can be improved because these variables are the most influential and significant on learning interest.
The Effect of Village Fund Allocation in Improving Community Welfare
Authors: Simamora️ Monika Devi Hotmauli , Gusnardi Gusnardi , Mujiono Mujiono
Published: November 2022

This study aimed to determine the effect of village fund allocation in improving community welfare in Sigotom Parratusan Village, Pangaribuan District, North Tapanuli Regency. The population in this study was the population of the village of Sigotom Parratusan totaling 1247 people. The sample in this study was 93 respondents. The sampling technique in this study used Stratified Random Sampling. The data collection technique in this study used a questionnaire arranged on a Likert scale. The analysis technique used in this research was simple regression. the coefficient of determination (R Square) was 0.623 or 62.3% the effect given by the independent variable (Village Fund Allocation) on the dependent variable (Improvement of Community Welfare) while the remaining 37, 7% was affected by other variables which included factors that affected the improvement of community welfare, the better the allocation of village funds, the higher the welfare of the community. The results of this study indicated that a good allocation of village funds had a contribution in improving the welfare of the community. This means that transparency, accountability, and participation could improve the welfare of the Sigotom Parratusan community, Pangaribuan District, North Tapanuli Regency.
A Case Report of Arteriovenous Fistula Penetrating into the Ascending Aorta Due to Right Internal Jugular Vein Placement
Authors: Meng Fanwei , Liu Zhi-Ping , Wang Jian
Published: November 2022

Internal jugular vein placement is frequently utilized in clinical practice for rapid infusion, intraoperative monitoring, peritoneal dialysis, and access for interventions. Additionally, the process may lead to complications like hematoma, infection, misdirection of the artery, pneumothorax, and arteriovenous fistula. In the case described in this report, all vascular ruptures effectively were repaired because when internal jugular vein placement was adopted, a dialysis catheter would go through the right internal jugular vein into the subclavian artery, then the ascending aorta via the cephalic trunk, and finally the ectopic catheter would be surgically removed. The patient was released from the hospital on the seventh postoperative day after maintaining stable vital signs throughout the procedure.
Short-Term Nutritional Support Improves The Preoperative Nutritional Status of Infants With Non-Restrictive Ventricular Septal Defect: A Prospective Controlled Study
Authors: Xu Li-Ping , Lin Shi-Hao , Zhang Qi-Liang , Zheng Yirong , Lin Guangming
Published: November 2022

Objective: To investigate the effect of short-term nutritional support on improving preoperative nutritional status of infants with non-restrictive ventricular septal defect.
Methods: A prospective randomized controlled study was conducted from June 2021 to December 2021 at a provincial children's hospital in China. The difference of nutritional status between the intervention group and the control group after short-term nutritional support was compared.
Results: After one month of nutritional support, the weight, STRONGkids score, albumin, prealbumin, and hemoglobin in the intervention group significantly were higher than those in the control group (P < 0.05). The postoperative intensive care time and discharge time of the two groups significantly were lower in the intervention group than those in the control group (P < 0.05).
Conclusion: The preoperative nutritional support of 1 month for infants with non-restrictive ventricular septal defect can effectively improve their preoperative nutritional status and promote postoperative recovery.
Development of Innovative Tools in Global Financial Markets
Authors: Danylkiv Khrystyna , Dropa Yaroslav , Petyk Marta , Hembarska Nataliia , Siryk Zinoviy
Published: November 2022

The purpose of the article is to study the theoretical foundations and develop practical recommendations for improving the process of functioning financial instruments in global financial markets. The article reveals the essence and characterizes the components of the modern global financial market, defines its role in the development of the national economy, and the peculiarities of its formation in the conditions of the expansion of innovative digital technologies. The essence of financial market instruments is revealed and the need to improve their investment qualities to the requirements of modern economic conditions is argued. Financial instruments that are in circulation on the financial market are systematized according to several features. Considerable attention is paid in the work to the circulation of innovative financial instruments, the main feature of which is a high level of risk. Peculiarities of the formation and functioning of derivative financial instruments were studied, and the essence and specifics of the use of credit notes on the stock market were revealed. The mechanism of circulation of credit notes is presented and their main functional features are defined. It is noted that the issuance and sale of credit notes enable borrowers to mobilize funds on the global financial markets, and improve their investment image in the international market through the formation of a high credit rating from global financial institutions. The peculiarities of cryptocurrency circulation on the global financial market from the point of view of today's most popular innovative financial instrument are revealed; the authors emphasized the dual nature of cryptocurrencies, as it has the properties inherent in stock market instruments and features that characterize financial pyramids. The dynamics of the development of the global cryptocurrency market over a long period have been analyzed. The peculiarities and problems of regulating the circulation and taxation of cryptocurrencies in Ukraine and the world are highlighted. The formation and specifics of circulation on the domestic financial market of bitcoin derivatives as a new financial instrument are described. The authors also focused attention on the spread of negative trends in the circulation of cryptocurrencies and substantiated possible ways to overcome them. The article analyzes the functioning and development of the option certificates and derivatives market in Ukraine in terms of stock and over-the-counter markets. The main factors restraining their development include inadequate regulatory and legal support, the small size of the markets, and a small number of tools used in them.
CATION CHANNELS - MOLECULAR TARGETS FOR POTENTIAL DRUGS WITH AN ANALGESIC MECHANISM OF ACTION
Authors:   A.V. Bogatsky Physical-Chemical Institute of NAS of Uktaine, Odesa, Ukraine, Golovenko M.Ya.
Published: November 2022

Ion channels ensure the functioning of the nervous system because they are involved in the depolarization of neurons, axonal conduction and the release of neurotransmitters. They are located in the membranes of all excitable tissues and are involved in the mechanisms of nociception. Modulation of ion channel signaling by small molecules can be effective in inhibiting the course of pain syndromes of various etiologies. A small number of ion channels are currently identified as potential targets for the development of antinociceptive drugs, as evidenced by medicinal chemistry data and various biophysical and pharmacological studies. This review provides examples of selective cation channel modulators as novel therapeutic agents for analgesia and prospects for the creation of innovative channel-targeted analgesic drugs.
The Health-Seeking Behavior of Diabetes Mellitus Patients during the COVID-19 Pandemic in Brebes Regency
Authors: Faisal Hiro Putra , Adiyatma Chrestella , Tyastuti Dwi
Published: November 2022

Background: The COVID-19 pandemic in Indonesia has impacted patients with non-communicable diseases such as Diabetes Mellitus (DM). The impacts include health services, treatment management, and patients' health-seeking behavior. This study aims to determine the DM patients' health-seeking behavior in the Salem sub-district, Brebes district, Central Java.Methods: This research was a qualitative descriptive study conducted cross-sectionally using a survey. The purposive sampling technique was employed to obtain the data with a total sample of 106 respondents.Results: Most DM patients still visited health facilities during the pandemic (73%). Some efforts to control DM were regularly taking medication (27.7%) and maintaining a healthy diet (34%). However, most respondents stated that they have uncontrolled blood glucose levels (54.7%). During the pandemic, respondents communicated with health workers (75.5%), via telephone (64.2%), and through messaging applications (45.3%). In addition, they search information, especially when they felt symptoms (90.6%), and tried to find information about complications due to the coronavirus (68.9%) with the source from health workers (94.3%). Most respondents had good access (99.1%).Conclusion: The COVID-19 pandemic has resulted changes in DM patients' health-seeking behavior through all aspects. This study shows that most respondents visited health facilities, made efforts to control DM by taking the medication regularly and maintaining a healthy diet, and had high adherence to medication. In addition, respondents had an easy access to health information and communicate with health workers via telephone and messaging applications. The majority of respondents sought information about diabetes and its relationship with COVID-19 during the pandemic.
Updates in Late-Onset Sepsis: Risk Assessment, Therapy, and Outcomes
Authors: Coggins Sarah A. , Glaser Kirsten
Published: November 2022

Neonatal late-onset sepsis (LOS) continues to threaten morbidity and mortality in the NICU and poses ongoing diagnostic and therapeutic challenges. Early recognition of clinical signs, rapid evaluation, and prompt initiation of treatment are critical to prevent life-threatening deterioration. Preterm infants—born at ever-decreasing gestational ages—are at particularly high risk for life-long morbidities and death. This changing NICU population necessitates continual reassessments of diagnostic and preventive measures and evidence-based treatment for LOS. The clinical presentation of LOS is varied and nonspecific. Despite ongoing research, reliable, specific laboratory biomarkers facilitating early diagnosis are lacking. These limitations drive an ongoing practice of liberal initiation of empiric antibiotics among infants with suspected LOS. Subsequent promotion of multidrug-resistant microorganisms threatens the future of antimicrobial therapy and puts preterm and chronically ill infants at even higher risk of nosocomial infection. Efforts to identify adjunctive therapies counteracting sepsis-driven hyperinflammation and sepsis-related functional immunosuppression are ongoing. However, most approaches have either failed to improve LOS prognosis or are not yet ready for clinical application. This article provides an overview of the epidemiology, risk factors, diagnostic tools, and treatment options of LOS in the context of increasing numbers of extremely preterm infants. It addresses the question of whether LOS could be identified earlier and more precisely to allow for earlier and more targeted therapy and discusses rational approaches to antibiotic therapy to avoid overuse. Finally, this review elucidates the necessity of long-term follow-up of infants with a history of LOS.
Neonatal Early-Onset Sepsis
Authors: Flannery Dustin D. , Puopolo Karen M.
Published: November 2022

Early-onset sepsis (EOS) is a significant cause of morbidity and mortality among newborn infants, particularly among those born premature. The epidemiology of EOS is changing over time. Here, we highlight the most contemporary data informing the epidemiology of neonatal EOS, including incidence, microbiology, risk factors, and associated outcomes, with a focus on infants born in high-income countries during their birth hospitalization. We discuss approaches to risk assessment for EOS, summarizing national guidelines and comparing key differences between approaches for term and preterm infants. Lastly, we analyze contemporary antibiotic resistance data for EOS pathogens to inform optimal empiric treatment for EOS.
Caring for Children of Incarcerated Parents
Authors: Martoma Rosemary A. , Kelleher Kelly J. , Kemper Alex R.
Published: November 2022

By age 18, one in fourteen American children has had a parent incarcerated. Although children from all backgrounds experience parental incarceration, racial and ethnic minority groups and those living in poverty are disproportionately affected. Parental incarceration is an adverse childhood experience that can negatively affect health and well-being over the life course. However, resilient children of incarcerated parents can flourish despite profound adversity. Pediatric providers should create safe, inclusive medical homes that foster sensitive disclosures and discussions about parental incarceration. If pediatric providers identify parental incarceration, they should promote foundational relationships and family resilience (including relationships with incarcerated parents when appropriate) and consider referrals to mental health specialists and specialized programs for children of incarcerated parents. Pediatric providers are also uniquely positioned to advocate for partnerships and policies that support children of incarcerated parents.
Scoring Systems to Predict Survival or Neurological Recovery after Out-of-hospital Cardiac Arrest
Authors: Naik Rishi , Mandal Indrajeet , Gorog Diana A
Published: November 2022

Numerous prediction scores have been developed to better inform clinical decision-making following out-of-hospital cardiac arrest (OHCA), however, there is no consensus among clinicians over which score to use. The aim of this review was to identify and compare scoring systems to predict survival and neurological recovery in patients with OHCA. A structured literature search of the MEDLINE database was carried out from inception to December 2021. Studies developing or validating scoring systems to predict outcome following OHCA were selected. Relevant data were extracted and synthesised for narrative review. In total, 16 scoring systems were identified: one predicting the probability of return of spontaneous circulation, six predicting survival to hospital discharge and nine predicting neurological outcome. NULL-PLEASE and CAST are recommended as the best scores to predict mortality and neurological outcome, respectively, due to the extent of external validation, ease of use and high predictive value of the variables. Whether use of these scores can lead to more cost-effective service delivery remains unclear.
Nordic Issue
Authors: Visuri Ingela
Published: November 2022

.
Knockdown of Bcl-3 alleviates psoriasis and dyslipidemia comorbidity by regulating Akt pathway
Authors: Wei Li  , Wei Yang  , Yang Can
Published: November 2022

Background: Psoriasis is considered as an inflammatory skin disease accompanied by dyslipid-emia comorbidity. B-cell leukemia-3 (Bcl-3) belongs to IκB (inhibitor of nuclear factor kappa B [NF-κB]) family, and regulates inflammatory response through associating with NF-κB. The role of Bcl-3 in psoriasis was investigated in this study.
Methods: Apolipoprotein E (ApoE)-deficient mice were treated with imiquimod to induce psoriasis and dyslipidemia. Mice were injected intradermally in the back with lentiviral particles encoding Bcl-3 small hairpin RNA (shRNA). Hematoxylin and eosin were used to detect pathological characteristics. The blood lipid levels were determined by automatic biochemical analyzer, and inflammation was assessed by enzyme-linked-immunosorbent serologic assay and real-time quantitative reverse transcription polymerase chain reaction.
Results: Bcl-3 was elevated in imiquimod-induced ApoE-deficient mice. Injection with lentiviral particles encoding Bcl-3 shRNA reduced Psoriasis area and severity index (PASI) score in ApoE-deficient psoriatic mice. Knockdown of Bcl-3 also ameliorated imiquimod-induced psoriasiform skin lesions in ApoE-deficient mice. Moreover, loss of Bcl-3 enhanced expression of loricrin, an epidermal barrier protein, reduced expression of proliferating cell nuclear antigen (PCNA) and lectin-like oxidized LDL (oxLDL) receptor-1 (LOX-1) in imiquimod-induced ApoE-deficient mice. The enhanced levels of blood lipid in ApoE-deficient mice were attenuated by silencing of Bcl-3 with increase of high-density lipoprotein, and reduction of total cholesterol, triglycerides, and low-density lipoprotein cholesterol. Knockdown of Bcl-3 attenuated imiquimod-induced decrease of transforming growth factor beta (TGF-β), and increase of Interleukin (IL)-17A, IL-23, IL-6, and tumor necrosis factor-α (TNF-α) in ApoE-deficient mice. Protein expression of phospho-Akt (p-Akt) and p-GSK3β in ApoE-deficient psoriatic mice was decreased by silencing of Bcl-3.
Conclusion: Loss of Bcl-3 exerted anti-inflammatory effect on psoriasis and dyslipidemia comorbidity through inactivation of Akt/GSK3β pathway.
Study of the specificity of gut microbiota in adult patients with delayed-onset of atopic dermatitis
Authors: Liu Ting , Chuan Yang  , Jia He  , Yujuan Wang  , Tengyao Hu  , Xiaoxiao Zhang
Published: November 2022

Background: Atopic dermatitis (AD) is a common and recurrent skin disease. The first onset of AD in adults is known as adult-onset atopic dermatitis (AOAD). Gut microbiota is closely associated with AD, and the “gut–skin” axis is considered as a novel target for prevention of AD. However, only a few studies have analyzed AOAD, particularly the studies that compared differences in intestinal flora between AOAD and persistent AD patients.
Objective: To investigate main specificities of intestinal microbiota in AOAD patients, particularly comparing with persistent AD patients.
Methods: A comprehensive taxonomic and functional analysis of gut microbiota in 10 healthy, 12 AOAD, and 10 persistent AD patients was done by using bacterial 16S ribosomal RNA (rRNA) gene analysis. Chao1 and Shannon diversity indices were measured to analyze alpha diversity, and the linear discriminant analysis (LDA) effect size (LEfSe) algorithm was applied to identify differences in genus.
Results: The alpha diversity of gut microbiota in AOAD patients was decreased, with Escherichiashigella (15.8%) being the predominant genus of AOAD group. Agathobacter and Dorea in AOAD patients were significantly reduced, whereas the relative level of Bacteroides pectinophilus group was remarkably elevated compared with healthy volunteers and persistent AD patients.
Conclusion: The present study revealed differences in intestinal flora between AOAD, healthy adults, and non-adult onset of AD, and explored differential dominant bacteria between AOAD and persistent AD patients.
Skolstrejk för klimatet och Hannah Arendt
Authors: Kring Elisabeth
Published: November 2022

Skolstrejk för klimatet startades av Greta Thunberg utanför Sveriges riksdag i augusti 2018 och kom med tiden att innefatta miljontals strejkande världen över. Skolstrejkerna uppkom som en protest mot brist på handlande från politiskt håll vad gäller att motverka klimatförändringar och miljöförstöring. Artikeln sätter fenomenet skolstrejk för klimatet i kontakt med Arendts idéer om politik, handlande och tänkande. Det föreslås i artikeln att skolstrejk för klimatet kan ses som dels krav på handlande (från andra, i detta fall vuxna och politiker), dels handlande i sig. På liknande sätt mejslar skolstrejkerna fram en dubbel barnposition. Barn ska inte behöva vara politiska aktörer, men de kan vara det, om vuxna inte handlar. Den klimatkris som uppkommit i och genom antropocen blir även till en utbildningens kris när skolstrejkande elever menar att framtiden räddas genom att lämna undervisningsrummet snarare än att vara där. Ett av budskapen från de skolstrejkande eleverna är att utbildning, med sin temporala dimension pekande mot en framtid, blir meningslös om det inte finns någon framtid. Detta analyseras i artikeln genom användande av Arendts åtskillnad mellan vetande (fakta) och tänkande (mening). Det argumenteras för att skolstrejk för klimatet påtalar behovet av tänkande i antropocen, och en typ av tänkande som leder till handlande i klimatfrågan.
Integration of Sufism Values into the Curriculum of Islamic Religious Education Subject in Junior High School
Authors: Abitolkha Amir Maliki , Mas'ud Ali
Published: November 2022

Sufism is a self awareness, a spiritual vibration, a trajectory in the heart, a whisper of conscience, a feeling of longing that is difficult to express in words. Sufism needs to be integrated in the curriculum of Islamic Religious Education (PAI) as it can affect the process of shaping students' attitudes, behaviors and characters. This article explains the importance of Sufism values combined with PAI materials. Through a literature review of the Junior High School (SMP) Islamic Religious Education books for grades VII-IX, using a content analysis approach, it was found that the PAI materials in general were still textual in nature, and lacked the insertion of Sufism values. Hence, it is urgent to integrate Sufism values into the Islamic Education curriculum, especially at the junior high school level because junior high school students are prone to experiencing moral crises and the process of searching for identity. Gradually, the steps of Sufism which need to be carried out in delivering the PAI materials in junior high school are takhalli (cleansing oneself from bad qualities), tahalli (filling the heart with good qualities), and tajalli (opening of divine light that permeate into oneself). The integration of Sufism values into the Islamic Education curriculum can shape students’ good attitudes and behaviors. Thus, learning PAI material becomes more effective in shaping noble morals for students.