bluuebunny/crossref_metadata_2025 huggingface dataset:
Human ILC1s target leukemia stem cells and control development of AML
Authors: Caligiuri Michael , Li Zhenlong , Ma Rui , Tang Hejun , Zhang Jianying , Marcucci Guido , Yu Jianhua
Published: January 2023

Innate lymphocytes can mediate cancer immunosurveillance and protect against disease. We have demonstrated that mouse type I innate lymphoid cells (ILC1s) can contribute to controlling the growth of acute myeloid leukemia (AML). However, the functional roles of human ILC1s in AML remain largely undefined. Here, we found that the ILC1s in patients with AML are impaired while a high expression of the ILC1 gene signature is associated with better overall survival in AML. By directly interacting with leukemia stem cells (LSCs), human ILC1s can eliminate LSCs via production of IFNγ and block LSC differentiation into M2 macrophage-like, leukemia-supporting cells through TNF. Collectively, these effects converge to limit leukemogenesis in vivo. We also identified Lin−CD127+CD161−CRTH2−CD117− cells as the human ILC1 subset. The use of umbilical cord blood (UCB) CD34+ hematopoietic stem cells to generate CD161− ILC1s could allow for a readily available supply of ILC1s to be produced for human adoptive transfer studies. Together, our findings provide evidence that targeting human ILC1s may be a promising therapeutic approach for prolongation of disease-free survival in AML.
Supporting Post-pandemic Recovery: A Qualitative Study of Capabilities, Opportunities, and Motivations to Deliver Oral Health Behaviour Change Messages to Parents of Young Children in Community Settings
Authors: Goldthorpe Joanna , Kilbee Lauren , Pretty Iain , Cotterill Sarah , Hart Jo , Peters Sarah
Published: January 2023

Background: The COVID-19 pandemic exacerbated vulnerabilities and inequalities in children’s oral health and treatment activity virtually ceased during periods of lockdown. Primary care dentistry is still in the post-pandemic recovery phase and it may be some years before normal service is resumed in NHS dentistry. However, opportunities to support the dental workforce through offering some preventative care in outreach settings may exist. This has the additional benefit of potentially reaching children who do not routinely see a dentist. The aim of this research was therefore to explore views around upskilling practitioners working in strategic community settings to support families of pre-school aged children to adopt and maintain preventative oral health behaviours.
Methods: Using the Capability, Opportunity and Motivation model of behaviour (COM-B) to structure our data collection and analysis, we conducted semi-structured interviews with 16 practitioners (dental and non-dental) and analysed the data using deductive framework analysis.
Results: The data was a good fit with the COM-B model and further themes were developed within each construct, representing insights from the data.
Conclusion: Early years practitioners can reach vulnerable children who are not usually brought to see a dentist and have capability, opportunity and motivation to support the oral health behaviours of families of children in their care. Further research is needed to identify training needs (oral health and behaviour change knowledge and skills), acceptability to parents, and supporting dental practice teams to work in partnership with early years settings.
High-density transcranial direct current stimulation to improve upper limb motor function following stroke: study protocol for a double-blind randomized clinical trial targeting prefrontal and/or cerebellar cognitive contributions to voluntary motion
Authors: Corominas-Teruel Xavier , Bracco Martina , Fibla Montserrat , Segundo Rosa Maria San , Villalobos-Llaó Marc , Gallea Cecile , Beranger Benoit , Toba Monica , Valero-Cabré Antoni , Colomina Maria Teresa
Published: January 2023

Background
Focal brain lesions following a stroke of the middle cerebral artery induce large-scale network disarray which has the potential to impact multiple cognitive and behavioral domains. Over the last 20 years, non-invasive brain neuromodulation via electrical (tCS) stimulation has shown the potential to modulate motor deficits and contribute to recovery. However, weak, inconsistent, or at times heterogeneous outcomes using these techniques have also highlighted the need for novel strategies and the assessment of their efficacy in ad hoc controlled trials.
Methods
We here present a double-blind, sham-controlled, single-center, randomized clinical trial involving participants having suffered a unilateral middle cerebral artery (MCA) stroke resulting in motor paralysis of the contralateral upper limb who will undergo a 10-days regime (5 days a week for 2 consecutive weeks) of a newly designed high-definition transcranial direct current stimulation (HD-tDCS) protocol. Clinical scale-based evaluations (e.g., Fugl Meyer, NIHSS, etc.), computer-based cognitive assessments (visuo-motor adaptation and AX-CPT attention tasks), and electroencephalography (resting-state and task-evoked EEG) will be carried out at 3 time-points: I) Baseline, II) Post-tDCS, and III) Follow-up. The study consists of a four-arm trial comparing the impact on motor recovery of three active anodal tDCS conditions: ipsilesional DLPFC tDCS, contralesional cerebellar tDCS or combined DLPFC + contralesional cerebellar tDCS, and a sham tDCS intervention. In every stimulation session, participants will receive 20 min of high-density tDCS stimulation (HD-tDCS) (up to 063mA/\({\text{c}\text{m}}^{2}\)) with a \({{\pi }\text{c}\text{m}}^{2}\) electrodes. Electrode-scalp positioning relative to the cortical surface (anodes and cathodes) and intensities are based on a biophysical optimization model of current distribution ensuring a 0.25V/m impact at each of the two chosen targets.
Discussion
Our trial will gauge the therapeutic potential of accumulative sessions of HD-tDCS to improve upper limb motor and cognitive dysfunctions presented by middle cerebral artery stroke patients. In parallel, we aim at characterizing changes in electroencephalographic (EEG) activity as biomarkers of clinical effects and identify possible interactions between the tDCS impact and motor outcomes. Our work will enrich our mechanistic understanding on prefrontal and cerebellar contributions to motor function and its rehabilitation following brain damage.
Trial registration
This study has been registered on ClinicalTrials.gov (NCT05329818)
Accumulation of biomass and nutrients in soybeans in an area of medium and high potential in the state of Mato Grosso, Brazil
Authors: Freitas Natasha Gomes , de Moraes Milton Ferreira , BINDE DAISY RICKLI , Castro Dione Aparecido , de Melo Suzana Pereira , Pascoalino João Augusto Lopes , Feletti Rômulo Caique Gonçalves
Published: January 2023

Aims
Substantial variation exists in the patterns of uptake and remobilization of nutrients by modern varieties of soybeans. Furthermore, the fertilization programs in Brazil are often outdated. Thus, the objective of this work was to analyze these patterns in a soybean cultivar with indeterminate growth habit in two areas, one with moderate and the other with high productivity.
Methods
We analyzed the dry matter, macro and micronutrients in soybeans (Glycine max) divided into leaves, stems, pods and seeds, in six growth stages. The plants came from established farming areas with the same cultivation parameters and indeterminate growth habit. The data were used for descriptive analysis in function dry matter production, uptake of nutrients, harvest index, and nutrient uptake and remobilization rate.
Results
We found a greater uptake of nutrients in the older cultivars, mainly involving nitrogen, potassium and sulfur. And the nutrient removal, denoted by the harvest index, varied according to the location, with a trend of export of greater quantities of nitrogen and phosphorus. These increases were positively related with the dry matter content but not with the nutrient export. The rate of uptake and remobilization of nutrients changed with demand for nutrients throughout the crop cycle.
Conclusions
For sustainable production of soybeans in Brazil, we suggest revision of the fertilization manuals to increase the average yield. Agronomic practices also need to assure adequate availability of nutrients during the reproductive growth stage.
Consanguineous couples’ experiences and views regarding expanded carrier screening: Barriers and facilitators in the decision-making process
Authors: Hout Sanne van der , Woudstra Anke , Dondorp Wybo , Sallevelt Suzanne , de Die-Smulders Christine , Paulussen Aimee , de Wert Guido
Published: January 2023

Expanded carrier screening (ECS) entails a screening offer for multiple recessive disorders at the same time, and allows testing of individuals or couples regardless of ancestry or geographic origin. Children ofconsanguineous couples have a higher-than-average risk of manifesting autosomal recessive disorders. This study aims to contribute to the responsible implementation of ECS for consanguineous couples. Seven semi-structured interviews were conducted with consanguineous couples who had recently participated in Whole Exome Sequencing (WES)-based ECS at Maastricht University Medical Center (MUMC+), the Netherlands. The test offered at MUMC+ covers a large number of disease-related genes (~2,000), including severe, relatively mild, early- and late-onset disorders. Respondents were interviewed about their views on, and experiences with participation in WES-based ECS. Overall, participation was experienced as worthwhile: it enabled respondents to make informed choices with regard to family planning as well as to take on the presumed parental responsibility to deliver their children as healthy as possible. Furthermore, our findings indicate that (1) true consent for having this test requires timely information about the possible implications of a positive test result for specific categories of findings, as well as about the success rates of the available reproductive options; (2) the clinical geneticist has an important task in correcting misconceptions about the kind of risk related to consanguinity; (3) more research is needed to explore what type of genetic risk information is considered ‘meaningful’ by participants and actually contributes to reproductive decision-making.
Emergence of flexible kesterite solar cells: progress and perspectives
Authors: Li Jianjun , Sun Kaiwen , Yuan Xiaojie , Huang Jialiang , Green Martin , Hao Xiaojing
Published: January 2023

Flexible photovoltaics have been and will be increasingly in demand in modern and future society in various applications. Searching for ideal flexible photovoltaic technologies that can perfectly meet these expanding demands has long been an active branch of photovoltaic research. Flexible kesterite Cu2ZnSn(S,Se)4 (CZTSSe) has emerged in recent years owning to its great potential to be an abundant, low-cost, stable, and high-efficiency “green” photovoltaic material that can be widely deployed with the lowest detrimental environmental impact. Here, we review the recent progress with flexible kesterite solar cells in thin-film and monograin technologies, discuss the key challenges and strategies associated with the flexible substrates, and finally provide future perspectives on further pushing the efficiency toward commercial-competitive levels.
C-S-H nucleation pathway from atomistic simulations
Authors: Aretxabaleta Xabier , López-Zorrilla Jon , Etxebarria Iñigo , Manzano Hegoi
Published: January 2023

C-S-H nucleation is a crucial step during cement hydration and determines to a great extent the rheology, microstructure, and properties of the cement paste. Recent evidences indicate that the C-S-H nucleation is non-classical, yet detailed information on the nucleation steps is still missing. In this work, we use atomistic simulation methods, specifically DFT, evolutionary algorithms (EA), and Molecular Dynamics, to investigate the structure and formation of C-S-H prenucleation clusters (PNCs) from the ions in solution, and then discuss a possible formation pathway for the C-S-H nucleation. Our simulations indicate that even for small sizes the most stable clusters feature C-S-H structural motifs, and we identified a C4S4H2 cluster candidate to be the C-S-H basic building block. We suggest a formation path in which small clusters formed by silicate dimers merge into large elongated aggregates. Upon dehydration, the C-S-H basic building blocks can be formed within the aggregates, and eventually crystallize.
Title: Impact of the COVID-19 pandemic on the severity of newly diagnosed cases of head and neck squamous cell carcinoma in southern Brazil
Authors: Ferrazzo Kívia Linhares , Danesi Cristiane Cademartori , Martins Nara Maria Beck , Antoniazzi Raquel Pippi
Published: January 2023

Purpose
Responsible for more than 360 thousand deaths in the world, head and neck squamous cell carcinoma (HNSCC) is an important public health problem worldwide, being more prevalent in men, smokers and alcoholics, aged over 40 years and with lower socioeconomic status. Some of these risk factors are also common to an increased risk of developing severe cases of COVID-19, the pandemic that has been affecting the world since the beginning of 2020. The aim of this study was to retrospectively assess the impact of the COVID-19 pandemic on the HNSCC diagnosis and severity of the disease in a hospital in southern Brazil.
Methods
All new cases diagnosed with HNSCC from March 11, 2019 to March 10, 2020 (pre-COVID-19 group) and all new cases diagnosed from March 11, 2010 to March 10, 2021 (COVID-19 group) were included. Data were obtained through histopathological reports and medical records.
Results
There was no difference in the number of new diagnoses in the COVID-19 group (n = 45) compared to the pre-COVID-19 group (n = 47). Patients' sociodemographic profile, time between diagnosis and treatment, and overall TNM staging were similar. However, the clinical N classification was more severe in the COVID-19 group (p = 0.021). Patients diagnosed during the COVID-19 pandemic were 4.05 times more likely to have more severe lymph node involvement (95% CI:1.62–10.12).
Conclusion
Although there was no reduction in the new diagnosis of HNSCC in the period of greater restriction of COVID-19 pandemic, the diagnosed cases showed lymph node metastasis in more advanced stages.
Chinese Herbal Medicine as an Adjunctive Therapy Ameliorated the Incidence of Hypotension in Patients with End-Stage Renal Disease: A Nationwide Population-Based Cohort Study
Authors: Chen Ying-Jung , Liu Chun-Ting , Chin Chieh-Ying , Lee Wen-Chin , Tsai Fuu-Jen , Cheng Ben-Chung , Chen Yung-Hsiang , Tsai Ming-Yen
Published: January 2023

Hypotension during hemodialysis (HD) is a common complication of dialytic patients that imposes an enormous burden on the healthcare system. A few studies show that Chinese herbal medicine (CHM) treatments confer a protective effect on hypotension in HD patients, but the long-term impact remains unclear. This study investigated the adjuvant therapy of CHM in HD patients to prevent the risk of hypotension in HD patients. We extracted data from the Taiwanese National Health Insurance Registry for Catastrophic Illness Patient Database (NHI_RCIPD) from 2008 and 2018 and analyzed them using multivariate Cox proportional hazard regression models. After 1:1 frequency-matching by age, index date, HD duration, monthly income, residential area, and medical comorbidities, 3820 HD patients who were using CHM and 3820 who were not using CHM were identified as CHM users and CHM non-users, respectively. The occurrence of taking vasopressors was identified as intradialytic hypotension (IDH). The Kaplan–Meier method was used to estimate the cumulative incidence curves of vasopressors of the subjects during the follow-up period. During 12 years of follow-up, 1710 CHM users and 1927 CHM non-users were prescribed vasopressors, representing IDH incidence rates of 119.8 and 246.2 per 1000 person-years, respectively. CHM users had significantly lower IDH risk compared with CHM non-users (adjusted HR = 0.51; 95%CI = 0.48, 0.55). A markedly predominant effect was observed in those receiving CHM for more than 180 days (adjusted HR = 0.43; 95%CI = 0.39, 0.48). Lower vasopressor use and IDH risk among HD patients correlated with the use of CHM treatments. Further studies about specific CHM modalities or medications for IDH are still needed.
Incidence and predictors of recurrent in-stent restenosis after drug-coated balloon angioplasty from central China
Authors: Liu Chuangxing , Meng Zhe , Sun Yunlong , Wang Xijia , Li Mingxuan , Gu Heping
Published: January 2023

Background: The efficacy and safety of DCB in treating ISR lesions has been widely validated, and the recurrence of ISR (RISR) emerges as one of the primary causes of recurrence of acute coronary syndrome that results in the requirement for multiple revascularizations.
Methods: This retrospective study enrolled patients with ISR lesions who were successfully treated by DCB in the First Affiliated Hospital of Zhengzhou University from September 2018 to September 2021. All patients during rehospitalization received the coronary angiography. According to whether there was RISR, the enrolled patients were divided into recurrent in-stent restenosis group (RISR group) and non-recurrent in-stent restenosis group (non-RISR group). The comparison of the basic data, laboratory parameters and the quantitative coronary angiography data at operation and follow-up between the two groups was caried out. According to RISR, multivariate logistic regression analysis was performed on the statistically significant baseline variables for further analysis.
Results: A total of 136 patients (147 ISR lesions) were enrolled in the study, 35.4% (52 lesions) developed RISR at follow-up, which lasted 13.6±8.5 months in average.Multivariate analysis revealed the independent association of high RDW, high % DS before procedure and the use of cutting balloon with RISR after DCB angioplasty(P<0.05).
Conclusion: At least 1/3 of patients with ISR lesions develop RISR after DCB dilation. High baseline RDW, high %DS before procedure, and the use of cutting balloon were identified as independent predictors of RISR.
Physico-chemical, thermo-physical and energy consumption analyzes of carrot chips produced by osmotic drying method
Authors: Taşova Muhammed
Published: January 2023

In present study, effects of drying methods (continuous and intermittent) and pre-treatments (dipping into 25% salt, 25% vinegar, 25% (salt + vinegar), 10% Pyracantha coccinea and 10% Malus floribunda solutions) on drying models, effective diffusion, dimensional traits, rehydration, color, shrinkage ratio, energy consumption, thermo-physical and some drying properties of carrot slices were investigated. Among the thin-layer drying models, Wang-Sing model yielded the best and Rational 1-parameter 2 model yielded the weakest estimations. Effective diffusion values varied between 2.96–9.12x10− 9 m2 s− 1 in continuous drying method and between 2.61–5.59x10− 9 m2 s− 1 in intermittent drying method. The greatest rehydration capacities were observed in samples dipped into 25% vinegar (82.88%) and 10% Malus floribunda (82.13%) solutions. The greatest volume change (92.60%) was observed in samples dipped into 10% Pyracantha coccinea solution and dried by continuous drying method. The lowest volume change (72.92%) was observed in control samples of intermittent drying method. In terms of chroma values, the samples dried by intermittent drying after dipping into 25% salt and 25% vinegar solutions yielded the closest values to the fresh samples. As an alternative drying method in terms of chroma value, dipping into 10% Pyracantha coccinea solution could also be selected in intermittent drying method. The greatest evaporation latent heat (ELH) value (10.62 kWh) was observed in samples dipped into 25% vinegar solution and the lowest ELH value (5.63 kWh) was observed in samples dipped into 25% (salt + vinegar) solution.
Air quality forecast model based on DBN-BP
Authors: Feng Mohan , Zhao Yongli
Published: January 2023

Ambient air quality is inseparable from people's production and life and social development, so the atmospheric environment monitoring system plays an irreplaceable role in environmental protection and pollution control. Use the real-time updated monitoring information to grasp the air pollution situation, evaluate and predict the environmental quality, and provide technical support for early warning decision-making, scientific air quality control, and regional joint prevention and control work. The existing air quality numerical prediction system WRF-CMAQ, due to the uncertainty of the pollution source emission inventory and the inability to fully quantify the physical and chemical changes in the atmospheric transmission, leads to deviations in the air quality forecast values. In view of the current situation of the existing air quality forecasting system, a deep belief network (DBN) model is proposed to mine the relationship between the predicted value of the numerical forecasting model and the measured value in the area, and establish an air quality forecasting model based on deep learning. The model utilizes the historical monitoring data of multiple Chinese monitoring stations in the study area and the corresponding meteorological forecast data, and fully considers the temporal variation and spatial distribution characteristics of atmospheric pollutant concentrations. During the forecast period, the forecast value of pollutant concentration at any site in the region is corrected to improve the effectiveness of the air quality forecast model.
Optimal dwelling time for ureteral stents placed for passive dilation after impassable ureteroscopy
Authors: Yildiz Ali Kaan , Bayraktar Arif , Kacan Turgay , Keseroglu Bugra Bilge , Ozgur Berat Cem , Doluoglu Omer Gokhan , Karakan Tolga
Published: January 2023

Purpose
The aim of this study was to determine the correlation between the dwelling time for a ureteral stent placed for passive dilation after impassable ureteroscopy and success and complications.
Methods
A retrospective evaluation was made of patients who underwent stent placement after impassable ureteroscopy and a repeat ureteroscopy due to kidney stones. A total of 161 patients were included in the study between 2015–2022. Demographic, clinical, preoperative, and perioperative data were collected. Logistic regression analyses were performed on the data showing a significant difference in the univariate analyses performed to determine the predictive factors of ureteroscopy after the stent dwelling period in terms of stone-free status and perioperative complications.
Results
Stone-free status was achieved in 110 (68.3%) of 161 patients, and perioperative complications were observed in 41 (25.4%). Factors that affected the stone-free status were determined as the dwelling time and the S-ReSC score, while factors affecting perioperative complications were the stent dwelling time and the operation time. The stone-free rates were observed to increase from 46.4% in the first 2 weeks to 72.9% after the 2nd week, an increase of 1.5-fold. Perioperative complications were determined at the rate of 17.5% during the first 5 weeks and increased 2.1-fold to 37.5% after the 5th week.
Conclusion
It can be recommended that great care is taken during the stent dwelling period and ureteroscopy should be performed within 5 weeks (14–35 days) but no earlier than 2 weeks, so as not to affect the success of the procedure.
Predictors of blisters in patients with acute compartment syndrome
Authors: Long Yubin , Wang Tao , Yang Shuo , Wu Limei , Ma Leilei , Dong Qi , Li Yiran , Guo Junfei , Hou Zhiyong
Published: January 2023

Introduction: Blisters, one of the most common complications of orthopedic trauma, can result in surgery delay and increase the risk of infection. This study aimed to identify the risk factors for blisters in patients with acute compartment syndrome (ACS).
Methods: We gathered data from two hospitals' 206 ACS patients from November 2013 to January 2021. Patients were divided into the blister group (BG) and the control group (CG) according to whether they had blisters or not. We used univariate analysis, logistic regression analysis, and receiver operating characteristic (ROC) curve analysis to determine the demographics, comorbidities, and admission laboratory tests.
Results: In our research, the incidence of blisters was 21.8 % (45 of 206). Univariate analysis showed that numerous factors were releated to the formation of blisters. According to logistic regression analysis, patients who developed ACS in the winter or spring (p = 0.007, OR = 2.690, 95% CI (1.308 to 5.534), patients who received a referral (p = 0.009, OR = 4.235, 95% CI (1.432 to 12.527), and patients with higher PLR (p = 0.036, OR = 1.005, 95% CI (1.000 to 1.009) were independent risk factors for blisters. In addition, a history of drinking (p = 0.039, OR = 0.027, 95% CI (0.046 to 0.927)) represented a protective factor for the formation of blisters in these patients. ROC curve analysis revealed that 138.17 was the cut-off value of PLR to predict the blister. Furthermore, the combination of seasonal factors, PLR, and referral had the highest diagnostic accuracy.
Conclusions: Our findings identified seasonal factors, referral, and patients with higher PLR as independent risk factors while a history of drinking as protective factor for blisters in ACS patients, allowing us to individualize the evaluation of the risk of blisters in order to perform early targeted therapies.
Characterization of poly (butylene adipate-co-terephthalate) PBAT co- polyesters degrading bacteria from farmland soil of Xinjiang
Authors: kanwal Aqsa , Zhang Min , sharaf Faisal
Published: January 2023

The use of poly (butylene adipate-co-terephthalate) (PBAT) has increased widely but PBAT-degrading bacteria have rarely been studied. During this study, we used farm soil (Shaanxi (yuan Jia cun)) to isolate and identify PBAT-degrading bacteria (Bacillus strains). We then accessed the effect of growth factors on PBAT degradation as well as the lipase activity of PBAT-degrading bacteria. The serial dilution method was used to isolate the PBAT-degrading microbes from the farm soil of Xinjiang. Microbial colonies were spread and streaked many times to get pure colonies. Xin-A and Xin-B were gram-positive bacteria. Lipase production of these strains was studied using para nitrophenyl palmitate as a substrate which showed that both bacteria were lipase producing and the lipase production of Xin-B (14 U/mL) was superior to Xin-A (11.7 U/mL) degrading almost 13.7% PBAT in 14 days. These results provide technical support for the highly efficient degradation of PBAT in the environment.
Modeling of Hybrid Henry Gas Solubility Optimization Algorithm with Deep Learning based LED Driver System
Authors: Ahamed Fayaz , Sukhi Y.
Published: January 2023

Light emitting diodes (LED) become an effective lighting solution because of the characteristics of energy efficiency, flexible controllability, and extended lifetime. They find use in numerous lighting systems for residents, industries, enterprises, and street lighting applications. The efficiency and trustworthiness of the LED systems considerably based on the thermal mechanical loading improved several degradation schemes and respective interfaces. The complication of the LED systems limits the theoretic interpretation of the core reasons for the luminous variation or the formation of the direct correlation among the thermal aging loading and the luminous output. Therefore, this article designs a new Hybrid Henry Gas Solubility Optimization with deep learning (HHGSO-DL) algorithm for LED driver system design. The presented HHGSO-DL technique mainly concentrates on the derivation of empirical relationships among the design parameters, thermal aging loading, and luminous outcomes of the LED product. In the presented HHGSO-DL technique, bidirectional long short-term memory (BiLSTM) algorithm is executed for examining the empirical relationship and its hyperparameters can be tuned by the HHGSO algorithm. In this work, the HHGSO algorithm is derived by the integration of traditional HGSO algorithm with oppositional based learning (OBL) concept. The performance of the HHGSO-DL technique can be investigated on LED chip packaging and LED luminaire with thermal aging loading. The extensive results demonstrate the promising performance of the HHGSO-DL technique over other state of art approaches.
Determinants of Puerperal Sepsis among Postpartum Women Admitted to Public and Private Hospitals in Dire Dawa City Administration, Eastern Ethiopia: Unmatched Case- Control Study
Authors: Mohammed Aminu , Belay Yalelet , Sintayehu Yitagesu , Nuri Aliya , Abera Legesse
Published: January 2023

Introduction: Puerperal sepsis is an infection of the genital tract occurring at any time from 2 to 42 days of puerperium. Maternal sepsis was responsible for 10.7% of the 295,000 maternal deaths worldwide. Various efforts are undertaken, but its burden remains as the third cause of maternal mortality in developing countries, including Ethiopia. However, there is a scarcity of data on determinants of puerperal sepsis in Ethiopia generally and not in the study area particularly.
Objective: This study aimed to assess determinants of puerperal sepsis among postpartum women admitted to public and private hospitals in Dire Dawa city administration from September to October 2022.
Methodology: A hospital-based unmatched-case control study was used among 600 postpartum women (150 cases and 450 controls). Cases (postpartum women with puerperal sepsis) and controls (postpartum women without puerperal sepsis) were selected by a systematic sampling technique. Data was collected using an interviewer-guided structured questionnaire and medical record review. The data was entered and cleaned by EPI DATA (Version 3.1) and analyzed using SPSS (Version 22) software. Bivariate and multivariate logistic regression, as well as odds ratios with 95% confidence intervals, were used to examine the effect of each independent variable on the outcome variable, and a P-value of 0.20 for transferring to multivariable analysis and a P-value of 0.05 for multivariable analysis were considered statistically significant.
Results: The determinants of puerperal sepsis were housewives (AOR = 2.24, 95% CI: 1.13-4.45), merchants (AOR = 2.98, 95% CI: 1.47-6.03), rural residence (AOR = 3.97, 95% CI: 2.34-6.74), home deliveries (AOR = 2.61, 95% CI: 1.02-6.70), cesarean deliveries (AOR = 2.40, 95% CI: 1.43-3.99), vaginal examinations (AOR = 3.50, 95% CI: 1.50-8.20), and prolonged rupture of membranes (AOR=1.91, 95%CI: 1.02-3.60)
Conclusion and recommendation: The majority of determinants of puerperal sepsis were related to obstetrics, along with occupation and residence. As a result, interventions involving coordinated and combined efforts to improve institutional delivery and use standard procedures during the labor and delivery process might take these factors into account.
A retrospective audit of Robotic versus Laparoscopic Anterior Resection for diverticular disease in a Single Surgeon’s Experience
Authors: Chiu Tricia , Chen Michelle Zhiyun , Guo Cici , Barto Walid
Published: January 2023

Purpose
There has been a shift towards elective resection for recurrent or complicated diverticular disease to prevent recurrent episodes of diverticulitis. Our study aims to compare the outcomes in elective robotic and laparoscopic anterior resection for diverticular disease by a single surgeon experienced in both techniques.
Method
This is a retrospective study of patients who underwent elective anterior resections at the Nepean Public Hospital, Nepean Private Hospital, and Sydney Adventist Hospital (SAN) in the last 10 years. The single surgeon is an experienced surgeon who has performed laparoscopic anterior resections from January 2013 to December 2018; and mainly robotic anterior resections from January 2018 to July 2022.
The primary outcome of this study was to determine if there were any differences in length of stay and post-operative complications in laparoscopic and robotic anterior resections. Secondary outcomes included operating time, rate of conversion to open surgery, and 30-day mortality and morbidity.
Results
53 patients included in this study. There was no significant difference in conversion to open rates (p=0.528), mean operative time (p=0.095), stoma formation rates (p=0.528) and post-operative complication rates (0.609). Length of stay was significantly shorter in the robotic group (p=0.024), and a higher proportion of patients who had laparoscopic surgery stayed for ≥6 days (p=0.08). There were no anastomotic leakages, or 30-day mortality and morbidity.
Conclusion
Robotic anterior resection is a feasible approach in experienced hands and produces comparable results to laparoscopic anterior resection for diverticular disease in terms of length of stay, post-operative complications and operative timings.
N-mode Minimal Tensor Extrapolation Methods
Authors: Bentbib Abdeslem Hafid , Jbilou Khalide , Tahiri Ridwane
Published: January 2023

The purpose of this work is to present, using the n-mode product, a new approach to generalize, for tensor sequence,s the well-known vector extrapolation methods MPE ( Minimal Polynomial Extrapolation method) and RRE (Reduced Rank Extrapolation method). We define the notion of the n-mode minimal polynomial of a matrix with respect to a tensor. This polynomial will be used, through the iterative solution of some tensor linear systems, to introduce the tensor version of MPE and RRE. These methods involve only the terms of sequences that result from the used iterative methods. The implementation of these methods on some sequences of tensors confirms the effectiveness and applicability of our approach.
Capturing College Students’ Happiness in Relation to their Classroom Engagement through Aristotle and St. Thomas Aquinas’ View
Authors: Sandoval Khristine L.
Published: January 2023

Happiness has been a vague term often described by psychologists, philosophers, and theologians. In connection to academe, the question lies on what factor does the happiness of the students mostly relies on. During the current pandemic, online learning has been widely promoted in replacement to traditional face-to-face classes to maintain youth’s learning at home which arises to different mental health issues affecting their classroom management. This paper proposes an understanding of the nature of happiness in young generation in relation to their classroom engagement with the thought of Aristotle and Aquinas. It uses qualitative study and exploratory method that applied in selected students of different ages and programs in a private university. This also suggest assessments of personal experiences on (1) personal classroom engagement, and (2) self-assessed individual happiness. Data are analyzed through the lenses of Aristotle, whose approach is focused on reasoning, and St. Thomas Aquinas, whose method is based on theology and faith. The results are grouped into different themes concerning the happiness, classroom engagement, and the relationship of the two. It also reveals different concepts of happiness of college students in Aristotle and Aquinas’ view and it was correlated to their classroom engagement on both synchronous and asynchronous online classes. Hence, this paper greatly impacts the purposive and meaningful life of the students, or in general, the society as a whole.
Some epileptic patients have an increased risk of dying sooner. Poor adherence-related epilepsy control
Authors: Bereda Gudisa
Published: January 2023

Background: Recurrent, spontaneous epileptic convulsions are the hallmark of epilepsy, a chronic illness. The likelihood of having an uncontrolled seizure was predicted by non-adherence to antiepileptic medicines (AEDs), the number of seizures that occurred before taking AEDs, and a head injury.
Case Presentation: On February 22, 2022, a self-employed, 26-year-old black male adult was taken to the medical ward with a seven-day history of recurring aberrant bodily movements. He had previously been treated with 100 mg of phenobarbitone for his epilepsy two years prior. On admission, he had a five-day history of anxiety, memory problems, diarrhea, sporadic fever, crying during the episode, uncontrollable jerking movements of the arms and legs, and partial loss of consciousness, in addition to a seven-day history of recurrent abnormal body movements. During his physical examination, an electroencephalogram showed that his brain was electrically active in an abnormal way. A computed tomography scan showed no lesions were present. A Glasgow Coma Scale reading of 10/15 was obtained during a neurological examination to assess his level of consciousness. When he arrived, he was given 10 mg of intravenous diazepam and three doses of 100 mg of oral phenobarbitone every eight hours.
Conclusion: Epilepsy affects people of all ages, ethnicities, sexes, levels of education, socioeconomic status, and social classes worldwide. Despite receiving the greatest care, seizure control may still be impacted by triggers or lifestyle choices.
Agroecology-Based Local Communities Vulnerability To Climate Change In Tembaro District, Southern Ethiopia
Authors: Uriga Degineh Herano , Mekuyie Muluken
Published: January 2023

Ethiopian agricultural system is almost all rain-fed agriculture systems, which is becoming more vulnerable to the impacts of climate change and variability. Identification of farmers’ vulnerability level is important to select appropriate adaptation options to climate change. Thus, this study aimed to examine the vulnerability of communities’ livelihood to climate variability and change based on different agro-ecological zones of the study area using the livelihood vulnerability index–intergovernmental panel on climate change (LVI–IPCC) method. The data was collected from a representative 154 sample households using stratified random sampling techniques. Also, the data was collected from December 2020 to February 2021 by interviewing the selected respondents, which was supplemented with focus group discussion and key informant interviews.
There was a difference in vulnerability status between the selected agro-ecologies in the district depending on their livelihood strategies, access to infrastructure, characteristics of the household, and available technologies. The analysis yielded that, the overall vulnerability score for communities in highland agroecology was 0.029, midland agroecology was 0.038, and lowland agroecology was 0.114, which indicates that communities in law land agroecology are more vulnerable relative to midland and high land agro-ecologies.
To enhance climate resilience or climate change adaptation strategies for vulnerable communities, there is a need to improve infrastructure facilities, diversification of livelihood strategies, provide improved seed varieties, and enhance soil and water conservation practices giving priority to more vulnerable communities. Decision-makers should plan adaptation in local contexts based on farmers' socioeconomic characteristics and livelihood strategies rather than adopting at international levels.
TINGKAT ACADEMIC SELF CONCEPT SISWA SMA PADA MATA PELAJARAN PAI & BP
Authors: Alamsyah Adam , Anwar Saepul , Suresman Edi
Published: January 2023

PAI & BP di jenjang SMA menuntut siswa memiliki kompetensi baik dari aspek kognitif, afektif, maupun psikomotor. Sedangkan persepsi kemampuan siswa meliputi kelebihan dan kekurangan dirinya terhadap mata pelajaran PAI & BP baik dalam mengikuti pembelajaran, memahami materi, serta mengaplikasikan nilai-nilai agama dalam keseharian itulah yang disebut academic self concept PAI & BP siswa. Penelitian ini bertujuan untuk mendeskripsikan bagaimana tingkat ASC siswa SMA pada mata pelajaran PAI & BP serta faktor-faktor yang mempengaruhinya guna menjalin komunikasi yang terbuka antara guru dan siswa serta menciptakan partisipasi aktif dalam kegiatan belajar mengajar antara guru dan siswa. Instrumen ASC PAI & BP yang digunakan adalah hasil modifikasi atas instrumen ASC Sains milik Graham Hardy (2013). Penelitian ini menggunakan pendekatan kuantitatif deskriptif metode sensus desain Cross-Sectional dengan instrumen angket kuesioner campuran untuk mengetahui tingkat ASC PAI & BP siswa dan faktor-faktor yang mempengaruhi ASC PAI & BP siswa. Hasil penelitian menunjukan bahwa tingkat ASC PAI & BP siswa SMA berada pada kategori tinggi yang berarti ASC PAI & BP siswa sebagian besar positif dimana 72,0% siswa memiliki ASC PAI & BP yang tinggi, 27,3% siswa memiliki ASC PAI & BP yang sedang, dan 0,6% siswa memiliki ASC PAI & BP yang rendah.
Gestão de riscos corporativos: estudo de caso do Itaú Unibanco S.A
Authors: Caldeira da Silva Mickaelle , Cunha Cardoso Camila , Carlos Torresani Paza Andrei , Luiz Bution Jefferson , Lotti Oliva Fábio
Published: January 2023

Objetivo do estudo: Este artigo objetiva ilustrar a aplicação de modelo teórico de Gestão de Riscos Corporativos (GRC) para identificar riscos e avaliar a maturidade da GRC considerando o ambiente de valor.
Metodologia/abordagem: Trata-se de estudo de caso representativo de alto nível de maturidade em GRC, o Itaú Unibanco S.A. O modelo teórico utilizado foi o de Oliva (2016), os dados foram coletados de documentos públicos do banco e de organizações do setor.
Principais resultados: Foram identificados os principais agentes do ambiente de valor da organização e os riscos das relações com estes agentes, com destaque para os riscos de imagem, financeiros e burocráticos. A partir de práticas identificadas, constatou-se que o Itaú Unibanco está no maior nível de maturidade em GRC.
Contribuições teóricas/metodológicas: Este estudo contribui com a literatura de gestão de riscos ao avançar modelo conceitual em direção a operacionalização, ilustrando aplicação em caso relevante e real.
Relevância/originalidade: O artigo contribui para a conexão entre a GRC e o ambiente de valor das organizações e avança em direção a operacionalização do modelo de Oliva (2016), originalmente teórico.
Contribuições sociais / para a gestão: O desenvolvimento da GRC nas organizações reduz a exposição a riscos de todo seu ambiente, aumentando a segurança da sociedade. O artigo contribui com a prática dos gestores ao demonstrar, de forma prescritiva, a aplicação de um modelo teórico de GRC.
Sincansarnıç Köyü (Mustafakemalpaşa-Bursa) Dolayının Stratigrafisi ve Mesozoyik Kireçtaşının Mermer Olarak Kullanılabilirliğinin Araştırılması
Authors: ÖÇGÜN Ali Gökhan
Published: January 2023

Çalışma alanı Bursa İli, Mustafakemalpaşa İlçesi, Sincansarnıç Köyü dolayını kapsamaktadır ve şehir merkezinin yaklaşık 50 km güneybatısındadır. İnceleme alanı H 21-d3 paftasında yer almaktadır. Çalışma alanında Mesozoyik yaşlı kayastratigrafi birimleri yüzeyler. Kırmızı–kahve renkli, hafif derecede metamorfizmaya uğramış birimlerden oluşan Karakaya gurubu Triyas yaşlı olup çalışma alanında geniş yayılımlıdır. Jurasik yaşlı Dağakça formasyonu çalışma sahasının kuzey bölümünde yüzeyleyip Karakaya gurubu kayaçları üzerine taban çakıltaşı ile açısal diskordanslıdır ve çakılları Triyas yaşlı taban biriminden türemedir. Üste doğru kumlu marn ve iri taneli kumtaşları ile devam eden birim kumlu kireçtaşına geçer. Fosilli biyomikritik yapılışlı, Erken Kretase (Berriasiyen-Valanjiniyen) yaşlı İnatlar kireçtaşı bölgede “Bursa Bej Mermeri” olarak tanınıp Dağakça formasyonu üzerine geçişlidir. Bu çalışma ile Sincansarnıç Köyü dolayının 1/25.000 ölçekli ayrıntılı jeoloji haritası, Genelleştirilmiş Stratigrafi Kesiti hazırlanmış, İnatlar kireçtaşının mühendislik özelliklerini saptamaya yönelik deneyler yapılmış ve ilgi kireçtaşının mermer olarak kullanılabilirliğine ilişkin fiziksel ve mekanik özellikler değerlendirilmiştir.
Düşük, Orta ve Yüksek Dayanım için Karar Ağacı Algoritmasıyla Beton Karışım Tasarımı
Authors: PARİM Coşkun , GÜNEŞ Mehmet Şamil , DİLBAS Hasan
Published: January 2023

Bu makale çalışmasında, mineral katkılı (silis dumanı) ve katkısız betonların karışım tasarımı için karar ağacı algoritmasıyla karışım tasarımı parametreleri 470 adet betona ait 3760 veri derlenerek belirlenmiştir. Elde edilen sonuçlar üzerinde yorumlar ve irdelemeler yapılmıştır. Karar ağacı algoritması sonuçları incelendiğinde, beton karışımları üzerinde en etkili parametreler belirlenmiştir. Elde edilen sonuçlar göstermektedir ki, her bir basınç dayanımı aralığı için en önemli parametre çimento dozajıdır ve diğer parametreler önem derecesine bağlı olarak daha sonra gelmektedir. Diğer yönden, yüksek basınç dayanımları arzulanması durumunda, ince madde içeriğinin belirtilen değerlere yakın olarak seçilmesi gerekli olup ince agreganın boşluk doldurucu etkisi ve sonucu olarak kompakt beton oluşumu/yüksek basınç dayanımı elde edilmesi ilişkisini göstermektedir denilebilir. Ayrıca elde edilen analiz sonucu farklı dayanım aralıkları için hangi karışım içeriğinden hangi miktarlarda seçilmesi gerektiğine %75 doğrulukla bir çözüm getirilmektedir. Böylelikle, beton karışım tasarımı için geliştirilmiş ilgili standartlardaki (örneğin, TS 802) detaylardan bağımsız olarak hangi dayanım için hangi beton içeriğinin seçilebileceği önerisi literatür verisi ile desteklenerek sağlanmıştır.
İplik Atıklarından Kapalı Döngü Geri Dönüşüm İplik Üretimi ve Fiziksel Özelliklerinin Sürdürülebilirlik Kapsamında Araştırılması
Authors: UYANIK Seval , PARLAKYİĞİT Pınar , OVALI Sabih
Published: January 2023

Tekstilde geri dönüşüm sürdürülebilirlik açısından oldukça popülerdir ve bu alanda birçok araştırmacı tarafından birçok çalışma yapılmış ve yapılmaya devam etmektedir. Bu çalışmada, Ne 10, Ne 20 ve Ne 30 olmak üzere 3 farklı iplik numarasında, ana lif olarak pamuk kullanılarak %10-50 telef içeren iplikler elde edilmiş ve telefin iplik özelliklerine etkilerinin ortaya çıkarılması amaçlanmıştır. Elde edilen verilerin grafiksel ve istatistiksel değerlendirmeleri sonucunda telefin iplik özelliklerini beklendiği kadar olumsuz etkilemediği belirlenmiştir. Harmanlanmış ipliklerdeki telef içeriği ve oranının iplik özelliklerini daha az etkilediği ve hatta önemli bir fark yaratmadığı düşünüldüğünde, telef iplik üretiminde Ne 10 en uygun iplik numarasıdır. İplik düzgünsüzlüğü ve iplik hataları açısından teleflerin optimum karışım oranı %30'dur. Ne 20 ipliklerin tüm özellikleri açısından %30 fire oranı en uygunu iken, Ne 30 ipliklerde tüylülük ve kopma mukavemeti açısından daha düşük fire oranlarına sahip iplik elde etmek makul gözükmektedir.
Wartime Leningrad Cinemas: During and After the Blockade
Authors:   South Ural State University, Volkov E. V. , Sapronov M. V. ,   South Ural State University
Published: January 2023

This article considers cinemas in Leningrad during the Great Patriotic War was a social space, which, using concept of the French sociologist Henri Lefebvre, can be considered as having three levels. First, there is a “representation of space”, that implies these aspects: how cinemas were represented and embodied in material forms (architectural appearance and interior decoration), and how the work of this institution was planned. The second level is “spatial practices”: the functioning of the cinema in real conditions through the activities of its employees, which could differ from orders from above. The third level is the “space of representations”, or how the cinema appears to viewers who visited it. During the Great Patriotic War, the social space of architectural structures in Leningrad cinemas largely remained the same as in the pre-war period. However, in wartime, mobilization acquired a larger character in cinemas. The spatial practices of cinema employees, whose composition has undergone changes in connection with the mass conscription to the front, labor mobilizations, diseases, and high mortality (mostly elderly and disabled people worked there) were also been transformed. The working day for cinema workers increased significantly. At the same time, a number of cinemas in Leningrad were temporarily closed and “conserved”. Cinemas as “spaces of representation” were associated for many viewers with a place of cultural practices, recreation, and distraction from the scourge of war. The repertoire of cinemas in Leningrad in contrast to the pre-war period, has changed significantly in the direction of increasing the display of newsreels, educational and documentary films, as well as military-historical feature films and “allied films” of American and British production.