bluuebunny/crossref_metadata_2025 huggingface dataset:
Immobilization of Cr(VI) in Soil Using a Montmorillonite-Supported Carboxymethyl Cellulose-Stabilized Iron Sulfide Composite: Effectiveness and Biotoxicity Assessment
Authors: Zhang Dading , Xu Yanqiu , Li Xiaofei , Liu Zhenhai , Wang Lina , Lu Chaojun , He Xuwen , Ma Yan , Zou Dexun
Published: August 2020

A novel composite of montmorillonite-supported carboxymethyl cellulose-stabilized nanoscale iron sulfide (CMC@MMT-FeS), prepared using the co-precipitation method, was applied to remediate hexavalent chromium (Cr(VI))-contaminated soil. Cr(VI)-removal capacity increased with increasing FeS-particle loading. We tested the efficacy of CMC@MMT-FeS at three concentrations of FeS: 0.2, 0.5, and 1 mmol/g, hereafter referred to as 0.2 CMC@MMT-FeS, 0.5 CMC@MMT-FeS, and 1.0 CMC@MMT-FeS, respectively. The soil Cr(VI) concentration decreased by 90.7% (from an initial concentration of 424.6 to 39.4 mg/kg) after 30 days, following addition of 5% (composite–soil mass proportion) 1.0 CMC@MMT-FeS. When 2% 0.5 CMC@MMT-FeS was added to Cr(VI)-contaminated soil, the Cr(VI) removal efficiency, as measured in the leaching solution using the toxicity characteristic leaching procedure, was 90.3%, meeting the environmental protection standard for hazardous waste (5 mg/kg). The European Community Bureau of Reference (BCR) test confirmed that the main Cr fractions in the soil samples changed from acid-exchangeable fractions to oxidable fractions and residual fractions after 30 days of soil remediation by the composite. Moreover, the main complex formed during remediation was Fe(III)–Cr(III), based on BCR and X-ray photoelectron spectroscopy analyses. Biotoxicity of the remediated soils, using Vicia faba and Eisenia foetida, was analyzed and evaluated. Our results indicate that CMC@MMT-FeS effectively immobilizes Cr(VI), with widespread potential application in Cr(VI)-contaminated soil remediation.
Strategies for Referring Cancer Patients in a Smoking Cessation Program
Authors: Davis James M. , Thomas Leah C. , Dirkes Jillian E. H. , Swartzwelder H. Scott
Published: August 2020

Most people who smoke and develop cancer are unable to quit smoking. To address this, many cancer centers have now opened smoking cessation programs specifically designed to help cancer patients to quit. An important question has now emerged—what is the most effective approach for engaging smokers within a cancer center in these smoking cessation programs? We report outcomes from a retrospective observational study comparing three referral methods—traditional referral, best practice advisory (BPA), and direct outreach—on utilization of the Duke Cancer Center Smoking Cessation Program. We found that program utilization rate was higher for direct outreach (5.4%) than traditional referral (0.8%), p < 0.001, and BPA (0.2%); p < 0.001. Program utilization was 6.4% for all methods combined. Inferring a causal relationship between referral method and program utilization was not possible because the study did not use a randomized design. Innovation is needed to generate higher utilization rates for cancer center smoking cessation programs.
A Comparison of the Acute Effects of Different Forms of Yoga on Physiological and Psychological Stress: A Pilot Study
Authors: Marshall Mallory , McClanahan McKenzie , McArthur Warren Sarah , Rogers Rebecca , Ballmann Christopher
Published: August 2020

Yoga is a frequently recommended stress management strategy; however, the acute stress response to varying types of yoga are not fully clear. Thus, the purpose of this study was to compare the acute effects of meditative and power yoga on indices of physiological and psychological stress. In a crossover counterbalanced design, physically active females (n = 13; age = 20.8 yrs ± 0.8, height = 164.5 cm ± 6.1, body mass = 65.0 kg ± 13.8) who did not regularly participate in yoga or mindful training enrolled in this study. Participants completed two visits each, with a standardized instructional-video 30-min yoga session with either A) meditative (Hatha style) yoga or B) power (Vinyasa style) yoga. Prior to and immediately after each yoga bout, psychological stress was assessed using the State–Trait Anxiety Inventory (STAI) questionnaire, and salivary cortisol samples were obtained to measure indices of physiological stress. State anxiety scores were significantly lower following meditative yoga (p = 0.047) but were not different following power yoga (p = 0.625). Salivary cortisol levels were significantly lower following meditative yoga (p = 0.020) but not following power yoga (p = 0.242). Results indicate that acute engagement in meditative yoga decreases markers of psychological and physiological stress, while power yoga does not impart a significant stress-relieving benefit. Findings indicate that differing types of yoga may have various stress-relieving capabilities and should be considered by individuals seeking anxiolytic benefits.
Impact of Psycho-Social Factors on Fatigue among Breast Cancer Patients Who Are Currently Undergoing Radiotherapy
Authors: Park Hyesun , Kim Kisook
Published: August 2020

Fatigue in breast cancer patients undergoing radiotherapy has been studied less comprehensively than fatigue from chemotherapy. The aim of this study was to test the impact of psycho-social factors on the fatigue among breast cancer patients undergoing radiotherapy. This was a cross-sectional correlational study and participants were 210 breast cancer patients currently undergoing radiotherapy in an outpatient setting in Korea. Data collection was carried out from 22 July to 30 September 2019. The results of this study showed that symptom assessment, anxiety and depression, uncertainty, and perceived stress had a direct effect on the fatigue of breast cancer patients receiving radiotherapy, while social support had an indirect effect. These factors explained 67.2% of the fatigue among the participants. This study confirmed that various interventions for symptom assessment, anxiety and depression, uncertainty, and stress reduction need to be developed to reduce fatigue of breast cancer patients receiving radiotherapy. The present results form the basis for developing such interventions.
Association of Liver Transaminase Levels and Long-Term Blood Pressure Variability in Military Young Males: The CHIEF Study
Authors: Liu Pang-Yen , Lin Yu-Kai , Chen Kai-Wen , Tsai Kun-Zhe , Lin Yen-Po , Takimoto Eiki , Lin Gen-Min
Published: August 2020

Background: An inverse relationship of serum liver transaminases and mortality might be due to better blood pressure control in hypertensive patients. Whether it holds true regarding such an association for long-term blood pressure variability (BPV) in those without antihypertensive therapy is unclear. Methods: A population of 1112 military males without antihypertensive medications, aged 32 years, was collected from a retrospective longitudinal study in Taiwan. Serum liver aspartate and alanine transaminase (AST and ALT) levels were obtained from a 12 h-fast blood sample of each participant. BPV was assessed by standard deviation (SD) and average real variability (ARV) of systolic and diastolic blood pressure (SBP and DBP), respectively across 4 visits during the study period (2012–2014, 2014–2015, 2015–2016, and 2016–2018). Multivariable linear regression analysis was utilized to determine the association adjusting for demographics, anthropometric indexes, SBP, DBP, and lipid profiles. Results: In the unadjusted model, ALT was significantly and positively correlated with SDDBP and ARVDBP (β (standard errors) = 0.36 (0.16) and 0.24 (0.12), respectively), and so was AST (β = 0.19 (0.08) and 0.14 (0.06), respectively). All the associations were insignificant with adjustments. However, ALT was significantly and negatively correlated with SDSBP and ARVSBP (β = −0.35 (0.14) and −0.25 (0.11), respectively) and so was AST (β = −0.14 (0.07) and −0.12 (0.06), respectively) with adjustments. Conclusion: Our findings suggested that serum liver transaminases were negatively correlated with long-term systolic BPV in young male adults without antihypertensive therapy, and the clinical relevance needs further investigations.
Is Improvement of Innovation Efficiency Conducive to Haze Governance? Empirical Evidence from 283 Chinese Cities
Authors: Fan Fei , Cao Dailin , Ma Ning
Published: August 2020

In recent years, haze pollution has had a wide impact in China. This research systematically studies the influence mechanism of haze pollution from a new perspective of urban innovation efficiency. We use a generalised space two-stage least squares method to analyse the correlation between urban innovation efficiency and haze pollution. The periodic and regional influences of urban innovation efficiency on haze pollution is explored using a threshold regression model. Through the mediating effect model, we accurately identify the transmission mechanism of urban innovation efficiency affecting haze pollution. The results show a significant inverted ‘U’ relationship between improvement of urban innovation efficiency and haze pollution. The regional innovation activities of innovative cities differ greatly from those of non-innovative cities. The effect of innovation efficiency improvement in innovative cities on haze governance is better than that of non-innovative pilot cities. In eastern cities with a higher level of economic development, the improvement of innovation efficiency has a stronger impact on haze governance. Industrial structure and population agglomeration have a mediating effect on the impact of urban innovation efficiency on haze pollution, providing directions for the rational formulation and effective implementation of haze governance policies in China, as well as in other countries.
Association of Infertility Treatment with Perception of Infant Crying, Bonding Impairment and Abusive Behavior towards One’s Infant: A Propensity-Score Matched Analysis
Authors: Sampei Makiko , Fujiwara Takeo
Published: August 2020

Background: Although previous qualitative studies suggested the link between infertility treatment and negative emotions towards infants, few empirical population-based studies have investigated the association of infertility treatment with the perception of infant crying, bonding impairment, and abusive behavior towards one’s infant. Methods: Women who participated in a four month health-checkup program in Aichi Prefecture, Japan (n = 6590) were asked to a complete a questionnaire that included infertility treatment history, perception of infant crying, maternal–infant bonding impairment assessed by the Mother to Infant Bonding Scale Japanese version, and abusive behavior towards one’s infant. Outcomes were dichotomized, and a conditional logistic regression was applied, using the propensity score match for infertility treatment exposure adjusted for known covariates. Results: A total of 690 participants (11.1%) reported infertility treatment history, and 625 cases were matched. We found that mothers with infertility treatment history were 1.36 times more likely to perceive a higher frequency of infant crying (95% confidence interval (CI):1.05–1.78), but no association with maternal–infant bonding impairment (odds ratio (OR): 1.18; 95% CI: 0.81–1.72) and abusive behavior towards the infant (OR: 0.82; 95% CI: 0.49–1.36). Conclusions: Infertility treatment may be associated with the perception of a higher frequency of infant crying, but it is not associated with bonding impairment and abusive behavior. Further longitudinal study is needed to replicate the findings.
Examining Health-Related Effects of Refurbishment to Parks in a Lower Socioeconomic Area: The ShadePlus Natural Experiment
Authors: Dobbinson Suzanne J. , Simmons Jody , Chamberlain James A. , MacInnis Robert J. , Salmon Jo , Staiger Petra K. , Wakefield Melanie , Veitch Jenny
Published: August 2020

Degraded parks in disadvantaged areas are underutilized for recreation, which may impact long-term health. Using a natural experiment, we examined the effects of local government refurbishments to parks (n = 3 intervention; n = 3 comparison) in low socioeconomic areas (LSEA) of Melbourne on park use, health behavior, social engagement and psychological well-being. Amenities promoting physical activity and sun protection included walking paths, playground equipment and built shade. Outcomes were measured via systematic observations, and self-report surveys of park visitors over three years. The refurbishments significantly increased park use, while shade use increased only in parks with shade sails. A trend for increased social engagement was also detected. Findings infer improvement of quality, number and type of amenities in degraded parks can substantially increase park use in LSEA. Findings support provision of shade over well-designed playgrounds in future park refurbishments to enhance engagement and sun protection behavior. Further research should identify park amenities to increase physical activity.
Maggot Therapy in Wound Healing: A Systematic Review
Authors: Mohd Zubir Mohd Zurairie , Holloway Samantha , Mohd Noor Norhayati
Published: August 2020

Background: It is estimated that 2% of the population in developing countries suffer from a chronic wound, making it a hidden phenomenon that is increasing as populations age. The ease of access to maggot therapy has made it increasingly attractive for implementation. This study aimed to explore the effectiveness of maggot therapy as compared to hydrogel dressings in the healing of chronic wounds. Methods: An electronic literature search until October 2019 was performed using Medline, Embase, and Cumulative Index of Nursing and Allied Health Literature. The eligibility criteria were chronic wound patients with an intervention that involved a comparison of any maggot species with hydrogel dressings. Results: The full text of five studies, involving 580 patients with chronic wounds, was retrieved. Four studies used the Lucilia sericata species. The maggot therapy facilitated faster and more effective debridement of non-viable tissue. It enabled faster development of granulation tissue and increased reduction in the wound surface area compared to hydrogel dressings. Maggot therapy had no effect on disinfection or complete healing rate for the wound. Conclusion: Maggot therapy should be considered for faster wound debridement, granulation tissue development, and wound surface area reduction as well as in surgical contraindications. This review can be used as a guide to assist clinicians in identifying patients who may benefit from maggot therapy.
Prevalence and Associated Factors of Urinary Incontinence among Chinese Adolescents in Henan Province: A Cross-Sectional Survey
Authors: Luo Yan , Zou Ping , Wang Kai , Cui Zhenti , Li Xiaomei , Wang Jing
Published: August 2020

Urinary incontinence is a common but understudied health problem in adolescents. This study aimed to investigate the prevalence of and associated factors for urinary incontinence in high-school-aged Chinese adolescents. A stratified two-stage cluster sampling procedure was adopted, yielding a sampling frame of 15,055 participants from 46 high schools in Henan province, China. Self-reported questionnaires were used to collect data. The urinary incontinence variable was assessed using the International Consultation of Incontinence Questionnaire-Short Form. The prevalence of urinary incontinence was 6.6%, with a female predominance (7.2% versus 6.0% in males; p < 0.05), and it increased with age, from 5.8% at 14–15 years to 12.3% at 19–20 years old (p < 0.001). The most common subtype of urinary incontinence was urgency urinary incontinence (4.4%), followed by stress urinary incontinence (1.7%) and mixed urinary incontinence (0.5%). Female sex, higher grades, more frequent sexual behavior, physical disease, chronic constipation, mental health problems, and residence in nonurban areas were significantly associated with higher odds of having urinary incontinence (p < 0.05). Public health programs, such as health education and school-based screening, should be established for early detection and appropriate management of urinary incontinence. Furthermore, individualized interventions targeting associated factors should be developed through collective efforts by adolescents, families, schools, and policymakers.
Helmert Transformation Problem. From Euler Angles Method to Quaternion Algebra
Authors: Ioannidou Stefania , Pantazis George
Published: August 2020

The three-dimensional coordinate’s transformation from one system to another, and more specifically, the Helmert transformation problem, is one of the most well-known transformations in the field of engineering. In this paper, its solution, in reverse problem, was investigated for specific data using three different methods. It is presented by solving it with the method of Euler angles as well as with the use of quaternion and dual-quaternion algebra, after first giving some basic mathematical theory. After research, not only were three artificial sets of data used, which were structured in a specific way and forced into specific transformations to be solved, but also a real geodesy problem was tested, in order to identify the sensitivity and problems of each method. Statistical analysis of the results was performed by each method, while it was found that there were significant deviations in rotations and translations in the method of Euler angles and dual quaternions, respectively.
The Spatial-Comprehensiveness (S-COM) Index: Identifying Optimal Spatial Extents in Volunteered Geographic Information Point Datasets
Authors: Lawrence Haydn , Robertson Colin , Feick Rob , Nelson Trisalyn
Published: August 2020

Social media and other forms of volunteered geographic information (VGI) are used frequently as a source of fine-grained big data for research. While employing geographically referenced social media data for a wide array of purposes has become commonplace, the relevant scales over which these data apply to is typically unknown. For researchers to use VGI appropriately (e.g., aggregated to areal units (e.g., neighbourhoods) to elicit key trend or demographic information), general methods for assessing the quality are required, particularly, the explicit linkage of data quality and relevant spatial scales, as there are no accepted standards or sampling controls. We present a data quality metric, the Spatial-comprehensiveness Index (S-COM), which can delineate feasible study areas or spatial extents based on the quality of uneven and dynamic geographically referenced VGI. This scale-sensitive approach to analyzing VGI is demonstrated over different grains with data from two citizen science initiatives. The S-COM index can be used both to assess feasible study extents based on coverage, user-heterogeneity, and density and to find feasible sub-study areas from a larger, indefinite area. The results identified sub-study areas of VGI for focused analysis, allowing for a larger adoption of a similar methodology in multi-scale analyses of VGI.
Using OpenStreetMap Data and Machine Learning to Generate Socio-Economic Indicators
Authors: Feldmeyer Daniel , Meisch Claude , Sauter Holger , Birkmann Joern
Published: August 2020

Socio-economic indicators are key to understanding societal challenges. They disassemble complex phenomena to gain insights and deepen understanding. Specific subsets of indicators have been developed to describe sustainability, human development, vulnerability, risk, resilience and climate change adaptation. Nonetheless, insufficient quality and availability of data often limit their explanatory power. Spatial and temporal resolution are often not at a scale appropriate for monitoring. Socio-economic indicators are mostly provided by governmental institutions and are therefore limited to administrative boundaries. Furthermore, different methodological computation approaches for the same indicator impair comparability between countries and regions. OpenStreetMap (OSM) provides an unparalleled standardized global database with a high spatiotemporal resolution. Surprisingly, the potential of OSM seems largely unexplored in this context. In this study, we used machine learning to predict four exemplary socio-economic indicators for municipalities based on OSM. By comparing the predictive power of neural networks to statistical regression models, we evaluated the unhinged resources of OSM for indicator development. OSM provides prospects for monitoring across administrative boundaries, interdisciplinary topics, and semi-quantitative factors like social cohesion. Further research is still required to, for example, determine the impact of regional and international differences in user contributions on the outputs. Nonetheless, this database can provide meaningful insight into otherwise unknown spatial differences in social, environmental or economic inequalities.
Leveraging OSM and GEOBIA to Create and Update Forest Type Maps
Authors: Brauchler Melanie , Stoffels Johannes
Published: August 2020

Up-to-date information about the type and spatial distribution of forests is an essential element in both sustainable forest management and environmental monitoring and modelling. The OpenStreetMap (OSM) database contains vast amounts of spatial information on natural features, including forests (landuse=forest). The OSM data model includes describing tags for its contents, i.e., leaf type for forest areas (i.e., leaf_type=broadleaved). Although the leaf type tag is common, the vast majority of forest areas are tagged with the leaf type mixed, amounting to a total area of 87% of landuse=forests from the OSM database. These areas comprise an important information source to derive and update forest type maps. In order to leverage this information content, a methodology for stratification of leaf types inside these areas has been developed using image segmentation on aerial imagery and subsequent classification of leaf types. The presented methodology achieves an overall classification accuracy of 85% for the leaf types needleleaved and broadleaved in the selected forest areas. The resulting stratification demonstrates that through approaches, such as that presented, the derivation of forest type maps from OSM would be feasible with an extended and improved methodology. It also suggests an improved methodology might be able to provide updates of leaf type to the OSM database with contributor participation.
The Flow of the Redox Energy in Quercetin during Its Antioxidant Activity in Water
Authors: Li Zhengwen , Moalin Mohamed , Zhang Ming , Vervoort Lily , Hursel Erik , Mommers Alex , Haenen Guido R. M. M.
Published: August 2020

Most studies on the antioxidant activity of flavonoids like Quercetin (Q) do not consider that it comprises a series of sequential reactions. Therefore, the present study examines how the redox energy flows through the molecule during Q’s antioxidant activity, by combining experimental data with quantum calculations. It appears that several main pathways are possible. Pivotal are subsequently: deprotonation of the 7-OH group; intramolecular hydrogen transfer from the 3-OH group to the 4-Oxygen atom; electron transfer leading to two conformers of the Q radical; deprotonation of the OH groups in the B-ring, leading to three different deprotonated Q radicals; and finally electron transfer of each deprotonated Q radical to form the corresponding quercetin quinones. The quinone in which the carbonyl groups are the most separated has the lowest energy content, and is the most abundant quinone. The pathways are also intertwined. The calculations show that Q can pick up redox energy at various sites of the molecule which explains Q’s ability to scavenge all sorts of reactive oxidizing species. In the described pathways, Q picked up, e.g., two hydroxyl radicals, which can be processed and softened by forming quercetin quinone.
Infrapatellar Fat Pad Gene Expression and Protein Production in Patients with and without Osteoarthritis
Authors: Belluzzi Elisa , Macchi Veronica , Fontanella Chiara , Carniel Emanuele , Olivotto Eleonora , Filardo Giuseppe , Sarasin Gloria , Porzionato Andrea , Granzotto Marnie , Pozzuoli Assunta , Berizzi Antonio , Scioni Manuela , De Caro Raffaele , Ruggieri Pietro , Vettor Roberto , Ramonda Roberta , Rossato Marco , Favero Marta
Published: August 2020

Osteoarthritis (OA) is one of the most common joint disorders. Evidence suggests that the infrapatellar fat pad (IFP) is directly involved in OA pathology. However, a comparison between OA versus non-OA IFP is still missing. Thus, the aim of this study was to compare IFP molecular, adipocytes and extracellular matrix characteristics of patients affected by OA, and patients undergoing anterior cruciate ligament (ACL) reconstruction. We hypothesized that not only inflammation but also changes in adipocytes and extracellular matrix (ECM) composition might be involved in OA pathogenesis. Fifty-three patients were enrolled. IFP biopsies were obtained, evaluating: (a) lymphocytic infiltration and vascularization; (b) adipocytes area and number; (c) adipo-cytokines and extracellular matrix gene expression levels; (d) IL-6 and VEGF protein production; (e) collagen fibers distribution. OA IFP was more inflamed and vascularized compared to ACL IFP. OA IFP adipocytes were larger and numerically lower (1.3-fold) than ACL IFP adipocytes. An increase of gene expression of typical white adipose tissue genes was observed in OA compared to ACL IFP. Collagen-types distribution was different in the OA IFP group compared to controls, possibly explaining the change of the biomechanical characteristics found in OA IFP. Statistical linear models revealed that the adipocyte area correlated with BMI in the OA group. In conclusion, inflammation and fibrotic changes of OA IFP could represent novel therapeutic targets to counteract OA.
Asymmetric Conservation within Pairs of Co-Occurred Motifs Mediates Weak Direct Binding of Transcription Factors in ChIP-Seq Data
Authors: Levitsky Victor , Oshchepkov Dmitry , Zemlyanskaya Elena , Merkulova Tatyana
Published: August 2020

(1) Background: Transcription factors (TFs) are main regulators of eukaryotic gene expression. The cooperative binding to genomic DNA of at least two TFs is the widespread mechanism of transcription regulation. Cooperating TFs can be revealed through the analysis of co-occurrence of their motifs. (2) Methods: We applied the motifs co-occurrence tool (MCOT) that predicted pairs of spaced or overlapped motifs (composite elements, CEs) for a single ChIP-seq dataset. We improved MCOT capability for the prediction of asymmetric CEs with one of the participating motifs possessing higher conservation than another does. (3) Results: Analysis of 119 ChIP-seq datasets for 45 human TFs revealed that almost for all families of TFs the co-occurrence with an overlap between motifs of target TFs and more conserved partner motifs was significantly higher than that for less conserved partner motifs. The asymmetry toward partner TFs was the most clear for partner motifs of TFs from the ETS (E26 Transformation Specific) family. (4) Conclusion: Co-occurrence with an overlap of less conserved motif of a target TF and more conserved motifs of partner TFs explained a substantial portion of ChIP-seq data lacking conserved motifs of target TFs. Among other TF families, conservative motifs of TFs from ETS family were the most prone to mediate interaction of target TFs with its weak motifs in ChIP-seq.
Validity of a Smart-Glasses-Based Step-Count Measure during Simulated Free-Living Conditions
Authors: Cristiano Alessia , Sanna Alberto , Trojaniello Diana
Published: August 2020

Step counting represents a valuable approach to monitor the amount of daily physical activity. The feet, wrist and trunk have been demonstrated as the ideal locations to automatically detect the number of steps through body-worn devices (i.e., step counters). Key features of such devices are high usability, practicality and unobtrusiveness. Therefore, the opportunity to integrate step-counting functions in daily worn accessories represents one of the recent and most important challenges. In this context, the present study aimed to investigate the validity of a smart-glasses-based step-counter measure by comparing their performances against the most popular commercial step counters. To this purpose, smart glasses data from 26 healthy subjects performing simulated free-living walking conditions along a predefined path were collected. Reference measures from inertial sensors mounted on the subjects’ ankles and data from commercial (waist- and wrists-worn) step counters were acquired during the tests. The results showed an overall percentage error of 1%. In conclusion, the proposed smart glasses could be considered an accurate step counter, showing performances comparable to the most common commercial step counters.
A Dialogue Concerning the Essence and Role of Information in the World System
Authors: Burgin Mark , Cárdenas-García Jaime F.
Published: August 2020

The goal of this paper is to represent two approaches to the phenomenon of information, explicating its nature and essence. In this context, Mark Burgin demonstrates how the general theory of information (GTI) describes and elucidates the phenomenon of information by explaining the axiomatic foundations for information studies and presenting the comprising mathematical theory of information. The perspective promoted by Jaime F. Cárdenas-García is based on Gregory Bateson’s description of information as “difference which makes a difference” and involves the process of info-autopoiesis as a sensory commensurable, self-referential feedback process.
Association between Early Anatomic Response and Intraocular Pressure Change after Intravitreal Dexamethasone Implant: An Optical Coherence Tomography Study
Authors: Kim Kyung Tae , Lee Hwanho , Kim Jin Young , Chae Ju Byung , Hyung Sungmin , Kim Dong Yoon
Published: August 2020

Purpose: To investigate the associations between early anatomical responses and intraocular pressure (IOP) changes in macular edema (ME) due to retinal vascular diseases treated with an intravitreal dexamethasone (DEX) implant. Methods: A retrospective review was conducted involving ME patients who underwent intravitreal DEX implantation. The eyes were divided into increased IOP (IIOP) or non-IIOP (nIIOP) groups according to the presence or absence of significant IOP elevation. Significant IOP elevation was defined by both the absolute value of IOP elevation (5 mmHg or higher) and an elevation percentage of the baseline IOP (an increase equal to 30% of the pre-injection IOP or higher). We analyzed the difference in central subfield thickness (CST) change according to the IOP elevation after DEX implantation. Relationships between IOP change and CST reduction after intravitreal DEX implantation were analyzed by Pearson correlation coefficients. Results: A total of 49 eyes, 29 with diabetic ME and 20 with ME due to retinal vein occlusion (RVO), were included in this study. Of the 49 eyes, 18 eyes (36.7%) were classified as IIOP group and 31 (63.3%) as nIIOP group. Significant differences in mean CST reductions over baseline one week after DEX implantation were observed between the groups. The degree of CST reduction from baseline to 1 week was significantly correlated with the degree of IOP change from baseline at 1 week and 1 month after intravitreal DEX implantation. Conclusions: In patients with ME due to retinal vascular diseases, we noted an early anatomical response significantly correlated with IOP change after intravitreal DEX implantation. Therefore, patients with favorable early anatomical responses to DEX implantation should be carefully monitored for IOP elevation.
Decreased Thymic Output Contributes to Immune Defects in Septic Patients
Authors: Sommer Natascha , Noack Steffen , Hecker Andreas , Hackstein Holger , Bein Gregor , Weissmann Norbert , Seeger Werner , Mayer Konstantin , Hecker Matthias
Published: August 2020

Background: Prolonged immunosuppression and hypoinflammation, termed compensatory anti-inflammatory response syndrome (CARS), contribute to high morbidity and mortality in the late phase of sepsis. Although apoptosis is a well-known cause of lymphopenia in sepsis, the contribution of thymic output to immune alterations in sepsis and potential compensatory mechanisms are largely unknown. Methods: We investigate the release of CD4+ T cells from the thymus and their peripheral proliferation by evaluating T-cell receptor excision circles (TREC) and the expression of CD31 as markers for recent thymic emigrants (RTE) and their proliferative offspring in septic patients with relevant lymphopenia in the CARS phase. Moreover, we determine the aging of T cells by measuring telomere characteristics. Results: In septic patients, we found decreased CD4+ T-helper cell numbers, while CD8+ T cell numbers were unchanged. As a possible cause, we detected increased apoptosis of CD4+ T-helper cells and decreased levels of IL-7, which promotes the maturation of T cells in the thymus. Accordingly, the relative number of mature CD4+ T cells, TREC-containing CD4+ T cells, and CD31+ RTEs (characteristic of thymic output) was decreased, while the relative number of CD31-T cells (peripherally expanded naïve T cells) was increased. Furthermore, the telomere length decreased, although telomerase activity and markers for the shelterin complex were increased specifically in CD4+ but not in CD8+ T cells. Conclusion: We thus conclude that, in addition to T-cell apoptosis, decreased thymic output and increased aging of CD4+ T cells may contribute to lymphopenia and immunosuppression in sepsis. Increased proliferation of peripheral T cells cannot compensate for these effects.
Effectiveness of Global Postural Reeducation in Ankylosing Spondylitis: A Systematic Review and Meta-Analysis
Authors: Gonzalez-Medina Gloria , Perez-Cabezas Veronica , Marin-Paz Antonio-Jesus , Galán-Mercant Alejandro , Ruiz-Molinero Carmen , Jimenez-Rejano Jose Jesus
Published: August 2020

The aim of this study was to determine the role of global postural reeducation for people with ankylosing spondylitis. We compared the effects of treatments on pain, dysfunction (using the Bath Ankylosing Spondylitis Disease Activity Index and Bath Ankylosing Spondylitis Functional Index), range of motion, and chest expansion in a specific population aged over 18 years old with ankylosing spondylitis. We performed a systematic review and meta-analysis following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statements. The search was conducted using the PubMed, Physiotherapy Database (PEDro), Scientific Electronic Library Online (SciELO), and Web of Science (WoS) databases. Clinical trials and systematic reviews/meta-analysis were reviewed. Results: 154 studies were found. Finally, four were included. Conclusions: global postural reeducation is beneficial for ankylosing spondylitis, but no more so than other conventional treatments, except for spinal mobility, where Global Postural Reeducation demonstrated an advantage.
Setting up a Virtual Calprotectin Clinic in Inflammatory Bowel Diseases: Literature Review and Nancy Experience
Authors: D’Amico Ferdinando , Netter Patrick , Baumann Cedric , Veltin Muriel , Zallot Camille , Aimone-Gastin Isabelle , Danese Silvio , Peyrin-Biroulet Laurent
Published: August 2020

Technological progress, including virtual clinics, web or smartphone-based applications, and assessment of fecal calprotectin (FC) at home has favored the implementation of treat to target strategies for patients with inflammatory bowel diseases (IBD). Although these innovations are promising and have been associated with a significant reduction in health costs, their application in clinical practice is limited. Here, we summarize the most recent literature on virtual clinics and available FC home tests. In addition, we report the experience of IBD patients monitored through the IBDoc® test at the Nancy University Hospital, focusing on usability testing and patient’s satisfaction. This pilot experience shows that a virtual calprotectin clinic doubles adherence rate to FC in IBD patients. This finding is especially clinically relevant in the post-coronavirus disease 2019 (COVID-19) pandemic era, with an increasing use of e-health.
Fatty Liver Disease and Non-Alcoholic Fatty Liver Disease Worsen the Outcome in Acute Pancreatitis: A Systematic Review and Meta-Analysis
Authors: Váncsa Szilárd , Németh Dávid , Hegyi Péter , Szakács Zsolt , Hegyi Péter Jeno , Pécsi Dániel , Mikó Alexandra , Erőss Bálint , Erős Adrienn , Pár Gabriella
Published: August 2020

The prevalence of fatty liver disease (FLD) and that of non-alcoholic fatty liver disease (NAFLD) share some risk factors known to exacerbate the course of acute pancreatitis (AP). This meta-analysis aimed to investigate whether FLD or NAFLD carry a higher risk of untoward outcomes in AP. In accordance with PRISMA guidelines, we performed a systematic search in seven medical databases for cohort studies that compared the outcomes of AP for the presence of FLD or NAFLD, and we calculated pooled odds ratio (OR) or weighted mean difference (WMD) with 95% confidence interval (CI). We included 13 articles in our meta-analysis. AP patients with FLD were more likely to die (5.09% vs 1.89%, OR = 3.56, CI = 1.75–7.22), develop severe AP (16.33% vs 7.87%, OR = 2.67, CI = 2.01–3.56), necrotizing pancreatitis (34.83% vs 15.75%, OR = 3.08, CI = 2.44–3.90) and had longer in-hospital stay (10.8 vs 9.2 days, WMD = 1.46, OR = 0.54–2.39). Patients with NAFLD were more likely to have severe AP and longer hospital stay. Both FLD and NAFLD proved to be independent risk factors of a more severe disease course (OR = 3.68, CI = 2.16–6.29 and OR = 3.39, CI = 1.52–7.56 for moderate/ severe vs. mild AP, respectively). FLD and NAFLD worsen the outcomes of AP, which suggests that incorporating FLD or NAFLD into prognostic scoring systems of AP outcomes might improve the prediction of severity and contribute to a more individualized patient care.
DNA Methylation in Adipose Tissue and Metabolic Syndrome
Authors: Panchal Sunil K. , Brown Lindsay
Published: August 2020

Epigenetics is the study of heritable phenotype changes that do not involve alterations in the DNA sequence with the processes including DNA methylation, histone modifications and RNA-associated silencing [...]
The Prevalence and Impact of Polycystic Ovary Syndrome in Recurrent Miscarriage: A Retrospective Cohort Study and Meta-Analysis
Authors: Mayrhofer Daniel , Hager Marlene , Walch Katharina , Ghobrial Stefan , Rogenhofer Nina , Marculescu Rodrig , Seemann Rudolf , Ott Johannes
Published: August 2020

Background: The use of different definitions and diagnostic approaches of polycystic ovary syndrome (PCOS) and recurrent miscarriage (RM) has led to a wide range of prevalence rates in the literature. Despite the persistent controversy about the factual prevalence of PCOS in RM, a vast number of studies have revealed evidence about their association with each other. The goals of this study were to evaluate the prevalence of polycystic ovarian morphology and PCOS within the RM population, performing meta-analyses with the obtained data from this study, together with previous reports on this topic and evaluating reproductive outcome in women with RM and PCOS. Methods: A retrospective cohort study with 452 women with RM and a meta-analysis were conducted. The main outcome parameter was the prevalence of PCOS in RM patients. Results: In the retrospective study, the prevalence of PCOS in RM was 9.5%. Negative results for the selected risk factors for RM were present in 283 patients (62.6%). From all evaluated possible underlying causes for RM, only the presence of thrombophilic disorders was significantly associated with PCOS (PCOS: 20.9% versus no PCOS: 7.8%, p = 0.010). In the meta-analysis of three studies on PCOS in RM patients, which used the revised Rotterdam criteria for defining PCOS, an estimated pooled prevalence of 14.3% (95% CI: 6.2–24.9) was found. In the retrospective data set, women in the PCOS group revealed significantly higher luteinizing hormone (LH), testosterone, and Anti-Mullerian hormone (AMH) levels than age- and body mass index (BMI)-matched controls with RM negative for the selected risk facotrs (p < 0.05). The rate of further miscarriages was significantly higher in PCOS women than in controls (71.4% versus 53.6%, respectively; p = 0.031). Conclusions: The prevalence of PCOS seems slightly increased in women with RM. Women with PCOS suffering from RM showed a significantly higher risk for further miscarriage and decreased chances of having a life birth of about 18% which did not reach statistical significance. Therefore, we assume that PCOS plays a moderate role in RM.
Hepatitis C Clearance by Direct-Acting Antivirals Impacts Glucose and Lipid Homeostasis
Authors: Graf Christiana , Welzel Tania , Bogdanou Dimitra , Vermehren Johannes , Beckel Anita , Bojunga Jörg , Friedrich-Rust Mireen , Dietz Julia , Kubesch Alica , Mondorf Antonia , Fischer Sarah , Lutz Thomas , Stoffers Philipp , Herrmann Eva , Poynard Thierry , Zeuzem Stefan , Dultz Georg , Mihm Ulrike
Published: August 2020

Background: Chronic hepatitis C virus (HCV) infections are causally linked with metabolic comorbidities such as insulin resistance, hepatic steatosis, and dyslipidemia. However, the clinical impact of HCV eradication achieved by direct-acting antivirals (DAAs) on glucose and lipid homeostasis is still controversial. The study aimed to prospectively investigate whether antiviral therapy of HCV with DAAs alters glucose and lipid parameters. Methods: 50 patients with chronic HCV who were treated with DAAs were screened, and 49 were enrolled in the study. Biochemical and virological data, as well as noninvasive liver fibrosis parameters, were prospectively collected at baseline, at the end of treatment (EOT) and 12 and 24 weeks post-treatment. Results: 45 of 46 patients achieved sustained virologic response (SVR). The prevalence of insulin resistance (HOMA-IR) after HCV clearance was significantly lower, compared to baseline (5.3 ± 6.1 to 2.5 ± 1.9, p < 0.001), which is primarily attributable to a significant decrease of fasting insulin levels (18.9 ± 17.3 to 11.7 ± 8.7; p = 0.002). In contrast to that, HCV eradication resulted in a significant increase in cholesterol levels (total cholesterol, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein (HDL-C) levels) and Controlled Attenuated Score (CAP), although BMI did not significantly change over time (p = 0.95). Moreover, HOMA-IR correlated significantly with noninvasive liver fibrosis measurements at baseline und during follow-up (TE: r = 0.45; p = 0.003, pSWE: r = 0.35; p = 0.02, APRI: r = 0.44; p = 0.003, FIB-4: r = 0.41; p < 0.001). Conclusion: Viral eradication following DAA therapy may have beneficial effects on glucose homeostasis, whereas lipid profile seems to be worsened.
Effect of Angle Opening Parameters on Corneal Endothelial Cell Density and Intraocular Pressure after Posterior Chamber Phakic Intraocular Lens Implantation
Authors: Kamiya Kazutaka , Ando Wakako , Tsujisawa Tatsuhiko , Takahashi Masahide , Shoji Nobuyuki
Published: August 2020

This study aimed to investigate the time courses of angle opening parameters and the relationships of these with the corneal endothelial cell density (ECD) and the intraocular pressure (IOP) after posterior chamber phakic intraocular lens (Visian ICLTM, STAAR Surgical) implantation. We evaluated 116 eyes of 59 consecutive patients (mean age ± standard deviation, 34.0 ± 8.8 years) who underwent V5 implantable collamer lens (ICL) implantation. Preoperatively and 1 day, 1 week, and 1, 3, and 18 months postoperatively, we quantitatively measured the angle opening distance at 500 µm (AOD500), the trabecular-iris space area (TISA500), and the trabecular iris angle (TIA500), using anterior segment optical coherence tomography (CASIA 2, Tomey), and assessed the relationships of these measurements with ECD and IOP in ICL-implanted eyes. All angle parameters (AOD500, TISA500, and TIA500) significantly decreased 1 day postoperatively but remained stable thereafter. At 18 months postoperatively, we found no significant correlations of the angle parameters with ECD (Pearson correlation coefficient r = −0.108, p = 0.249 for AOD500; r = −0.162, p = 0.083 for TISA500; r = −0.022, p = 0.815 for TIA500) or between the angle parameters and IOP (r = −0.106, p = 0.256 for AOD500; r = −0.021, p = 0.826 for TISA500; r = −0.018, p = 0.850 for TIA500). The angle opening metrics significantly decreased immediately after ICL implantation but remained stable thereafter. Narrowing of the angle did not significantly affect ECD or IOP in ICL-implanted eyes during the 18-month postoperative period.
Materno-Fetal and Neonatal Complications of Diabetes in Pregnancy: A Retrospective Study
Authors: Capobianco Giampiero , Gulotta Alessandra , Tupponi Giulio , Dessole Francesco , Pola Maddalena , Virdis Giuseppe , Petrillo Marco , Mais Valerio , Olzai Giorgio , Antonucci Roberto , Saderi Laura , Cherchi Pier Luigi , Dessole Salvatore , Sotgiu Giovanni
Published: August 2020

The aim of this case–control study was to evaluate maternal–fetal and neonatal clinical outcomes in a group of patients with gestational diabetes mellitus (GDM) and pregestational diabetes such as diabetes mellitus type 1 (DM1) and diabetes mellitus type 2 (DM2) and compare them with those of patients without diabetes. A total of 414 pregnant women, nulliparous and multiparous, with single pregnancy were recruited. The selected patients were divided into two groups. Among 207 patients (group cases), 183 had GDM and 24 pregestational diabetes (of which n = 17 diagnosed with DM1 and n = 7 with diagnosis of DM2). Two-hundred-seven patients with a negative pathologic history of GDM, DM1 and DM2 represented the population of controls (group control). We reported an incidence of preterm delivery of 23.2% in the group of cases, of 18.3% in the group of patients with GDM and 66.7% in the group of patients DM1/2. Fetal growth disorders, such as intrauterine growth retardation (IUGR), small for gestational age (SGA), fetal macrosomia, were detected in four fetuses out of 207 (1.93%) in the control group and 20 fetuses out of 207 in the case group (9.67%, p-value 0.001); of these 16 of 183 fetuses of the GDM group (8.74%, p-value 0.002) and 4 of 24 fetuses of the DM1/2 group (16.67%, p-value 0.005). A very strong correlation between diabetes mellitus type 1 and preeclampsia (p-value < 0.0001) was observed. Close monitoring of pregnant women with diabetes is recommended to prevent maternal–fetal and neonatal complications.