bluuebunny/crossref_metadata_2025 huggingface dataset:
A consistent definition of cultural safety within Australian health professional education: a scoping review
Authors: Brumpton Kay , Evans Rebecca , Ward Raelene , Sen Gupta Tarun
Published: August 2022

This scoping review aims to explore how cultural safety is defined in the Australian literature with health professional learners in clinical interactions. It maps how the components of the Australian Health Practitioner Regulation Agency definition of cultural safety align with this evidence. Databases were systematically searched for original, peer-reviewed research that included Australian Aboriginal and Torres Strait Islander peoples, health professional learners who were eligible for registration in Australia, teaching and assessment. Many elements of cultural safety lacked Indigenous input and had no patient involvement. General consultation and communications skills were key components of culturally safe interactions. The Australian Health Practitioner Regulation Agency consensus statement on cultural safety provides a consistent definition for teaching and learning cultural safety within health professions in Australia. The findings suggest that developing an approach for cultural safety requires incorporation of Indigenous voices, patient-centred care metrics, patient feedback, learner self-assessment and attitude measures.
Barriers and Facilitators to Substance Use Disorder Treatment: An Overview of Systematic Reviews
Authors: Farhoudian Ali , Razaghi Emran , Hooshyari Zahra , Noroozi Alireza , Pilevari Azam , Mokri Azarakhsh , Mohammadi Mohammad Reza , Malekinejad Mohsen
Published: August 2022

objective:

This investigation explored the barriers and facilitators to substance use disorder (SUD) treatment in the integrated paradigm.

methods:

A search technique for barriers and facilitators of SUD treatment was applied to the PubMed and Web of Science databases to identify relevant systematic reviews. The eligibility criteria included systematic review (SR) or SR plus meta-analysis (MA) articles published before the end of 2021, human research, and the English language. Each of the 12 relevant review articles met the inclusion criteria. AMSTAR was utilised to evaluate the methodological quality of the systematic reviews.

results:

Two authors analysed 12 SR/SR-MA articles to identify barriers or facilitators of SUD treatment. The cumulative summary results of these 12 evaluations revealed that barriers and facilitators may be classified into 3 levels: individual, social and structural. By analysing these review papers, 37 structural barriers, 21 individual barriers and 19 social barriers were uncovered, along with 15 structural facilitators, 9 social facilitators and 3 individual facilitators.

conclusions:

The majority of barriers indicated in the review articles included in this analysis are structural, as are the majority of facilitators. Consequently, the design of macro models for the treatment of substance use disorders may yield various outcomes and potentially affect society and individual levels.
Predictors of Hand-Washing Practices at Critical Times Among Mothers of Under-5 Years Old Children in Rural Setting of Gedeo Zone, Southern Ethiopia
Authors: Agaro Ashenafi , Hareru Habtamu Endashaw , Muche Temesgen , Sisay W/tsadik Daniel , Ashuro Zemachu , Negassa Belay , Legesse Mehret Tesfu , Kaso Abdene Weya , Alemu Wagaye , Alemayehu Gube Addisu , Aregu Mekonnen Birhanie , Soboksa Negasa Eshete
Published: August 2022

Background:

Various communicable and infectious diseases could be contained by proper hand washing leading to a reduction in mortality and morbidity of children.

Objective:

To assess predictors of hand-washing practices at critical times among mothers of under 5 years old children in rural setting of Gedeo zone, Southern Ethiopia.

Method:

An institutional-based cross-sectional survey was conducted among 422 women with children under the age of 5 attended the Dilla Zuria health facility and were chosen using a systematic sampling method. Data was gathered using pre-tested interview-administered structured questionnaires. Data was entered into EPI info version 17 and analyzed using SPSS version 25. Binary logistic regression was employed to identify the association between dependent and independent variables. Finally, for variables with a P < .05 in multivariable analysis, adjusted odds ratio (AOR) with a 95% confidence interval (CI) was determined and interpreted.

Results:

The hand washing practice of mothers at critical times was 44.9% [95% CI: 40.1, 49.7%]. The pertinent predictors were favorable attitude [AOR = 7.77, 95% CI: 4.56, 10.37], availability of water source near the household [AOR = 5.31, 95% CI: 3.56, 10.37], and constant availability of soaps at household [AOR = 2.32, 95% CI: 1.33, 6.70].

Conclusion:

In our study, hand-washing practices at critical times was low. The pertinent predictors were attitude, the presence of a water source near the household, and the presence of soap. Therefore, it is advised to encourage domestic hygiene education to improve mothers’ attitudes and to increase the availability of water and soap close to the household to promote handwashing with soap and water at critical times.
Development journalism and revitalisation of familism in Malaysia
Authors: Imran Muhammad Asim
Published: August 2022

This paper explores the role of Malaysian media in the revitalisation of familism, which seems to descend in most Asian societies. The examination of news articles published in English-language Malaysian newspapers between 2011–2021 through critical discourse analysis reveals that newspapers in Malaysia are playing a moral guardianship role by warning readers of the slipping of filial responsibility and the dangers of the alternatives. The papers construct a discourse in support of an established social norm of traditional family roles in caring for family members – particularly, elderly people who are on the rise throughout the world – something the government supports as well, as it relieves it of any obligation to elderly citizens. The role of journalists in the rekindling of familial piety can be linked to development journalism that emphasises the media's partnership with the government as care of older family members absolves the government from the cost of care associated with an increasingly ageing population.
Tribo-mechanical analysis of magnesium-based fibre metal laminates for structural applications
Authors: Priya I. Infanta Mary , Arul Jeya Kumar A.
Published: August 2022

Fibre metal laminates (FML) play a significant role in the aircraft industry. The present work is to achieve a high load bearing structure and wear resistant FML for airbus cargo floors and doors. An innovative attempt has been made to reveal the mechanical and tribological properties of the FML (Glass/AZ91D/Glass). The glass fibre used is of bi-diagonal fabric to enhance the shear properties of the FML. The laminates were prepared by hand layup technique, which was post compressed to a uniform shape in the compression moulding machine. Mechanical tests such as tensile, flexural, and low-velocity impact were conducted on the FML samples. The mechanical properties of the magnesium-based FML exhibit an excellent tensile strength of 227.3 MPa, the flexural strength of 231.3 MPa, and the energy absorbed by the plate are 93.648 J. These results were promising, and comparatively better than the conventional laminates in the case of load bearing structures. The wear was tested in Pin-on-Disc and the wear resistance was also found to be better than conventional laminates. The micro-structural analysis along the wear regime shows a prominent wear resistance and fewer cracks, due to the presence of AZ91D in the laminates.
Interaction between psychological ownership and psychological resilience toward the destination
Authors: Mishra Sita , Shukla Yupal , Malhotra Gunjan , Johann Maria
Published: August 2022

The tourism sector was badly affected by the ongoing Covid-19 pandemic, creating thereby a need to advance knowledge on developing strategies for bringing tourists to back their favourite destinations. Although studies in tourism literature in the last two years addressed several issues relating to the pandemic, ironically not many have explored the role of tourists’ attitude towards a destination. Specifically, there have hardly been any discussions on the tourists’ psychological ownership vis-à-vis destination affinity (DA). It's an irony because they play crucial roles in leading tourists to revisit their favourite destinations. Using the ‘Psychological Resilience Theory’, this study focuses on the Covid-19 crisis and examines the relationship between attitude towards the destination, psychological ownership towards the destination, DA, and desire to revisit the destination post-Covid-19 crisis. Data (N = 274) was collected online from Indian tourists and hypothesis testing was done using PROCESS SPSS macro. The findings of the study indicated the mediating impact of DA and moderating role of psychological resilience. This study offers several important implications for tourism literature and the sector at large.
“Mending fractured personalities”: A photography-based cultural study of recovery from mental distress in Romania
Authors: Milasan Lucian Hadrian
Published: August 2022

This study explored the lived experiences and meanings of recovery from mental distress from the perspective of mental health service users in Romania, along with investigating cultural particularities of recovery in this country. Research in this area is essential in the context of Romania's mental health reform marked by a transition from institutionalised mental health services to a recovery-based approach, and profound social and economic changes during the post-communist era. Subscribing to the recovery framework, this study employed a qualitative phenomenological design involving 15 adults with mental health problems purposively recruited from a community day centre in Romania. The phenomenological background was enriched with elements of participatory photography to elicit subjective experiences and meanings of recovery. The outcome of this study was a better understanding of recovery in Romanian adults living with mental distress, as a complex and multi-layered phenomenon. Three key themes were identified through Interpretative Phenomenological Analysis: awakening, healing, and reconstructing life. The findings add to the current recovery models by showing that recovery cannot be fully understood unless situated in a socio-political, cultural, and historical context. Implications for mental health practice in Romania are discussed and directions for future research are recommended.
Why does gender inequality in academic publishing persist? Lessons and recommendations
Authors: Hagemann Sara
Published: August 2022

Data from leading scholarly journals and publishing houses show that the gender gap in academic publishing is deep and persistent. This has considerable consequences for individual careers and for academic knowledge across disciplines. As European political science journals have started to publish their gender data for submissions and publication processes, this article evaluates this trend and the conclusions from a recent symposium on ‘The gendered distribution of authors and reviewers in major European political science journals’. It summarises a list of ‘key gender data’ that journal editors are encouraged to publish on an annual basis to achieve a more accurate and comprehensive picture for individual journals and across the discipline. It also includes suggestions for editors to ensure better citations of female scholars in their journals.
Professional Training and Therapeutic Resources Needed for the Adoption of Telepractice in the Philippines
Authors: Lentejas Kembell Gaw , Lam Joseph Hin Yan , Tong Shelley Xiuli
Published: August 2022

With the COVID-19 pandemic necessitating the adoption of telepractice for providing speech and language therapy services, this study investigated the factors affecting the perceptions and the implementation of telepractice for school-age children by speech-language pathologists (SLPs) in the Philippines. Sixty-four SLPs completed a 36-item online survey assessing the adoption of telepractice, implementation concerns, student candidacy, continuous training in telepractice, and the SLPs’ demographics. The SLPs reported that they quickly adopted telepractice in their services for school-age students at the start of the pandemic. Multiple linear regression analyses revealed that SLPs’ perceptions of the effectiveness of telepractice were significantly affected by implementation difficulties while SLPs’ future use of telepractice was significantly predicted by training and resource availability. These results suggest that professional training and other therapeutic resources are needed to alleviate SLPs’ concerns about difficulties in implementing and continuing use of telepractice.
Diagnosis and Management of Intravenous Drug Users’ Chronic Wounds: A Case Series Collection of a Single Center
Authors: Starace M. , Viviani F. , Carpanese M. A. , Alessandrini A. , Sechi A. , Patrizi A. , Bianchi T.
Published: August 2022

Background: Intravenous drug users (IVDUs) represent a very small group of patients affected by chronic wounds (CWs). Objectives: To assess the risk factors for CWs in IVDUs, to improve their treatment. Methods: A retrospective review of 7 IVDUs with CWs was performed at the Dermatology of the University of Bologna. Results: A history of 10 years of the most frequent injection was heroin in the gaiter area. The most observed comorbidities were HIV, HCV and HBV. They were treated most with an alginate with silver dressing with an average follow-up of 2.8 years. Conclusions: We would like to highlight the importance of clinical history in this type of patients and that in our experience specialized skin wounds risk assessment and management could be useful, aside from traditional compression therapy.
Oh, What a Tangled Web Epilepsy Genes May Weave
Authors: Gallagher Martin J.
Published: August 2022

[Box: see text]
Reduced Equol Production and Gut Microbiota Features in Men With Lean Nonalcoholic Fatty Liver Disease
Authors: Iino Chikara , Endo Tetsu , Iino Kaori , Tateda Tetsuyuki , Sato Satoshi , Igarashi Go , Mikami Kenichiro , Sakuraba Hirotake , Yokoyama Yoshihito , Nakaji Shigeyuki , Fukuda Shinsaku
Published: August 2022

Patients with lean nonalcoholic fatty liver disease (NAFLD) may have different metabolic profiles than those with NAFLD. Estrogenic activity is associated with NAFLD pathogenesis. We evaluated the production ability of equol, which has estrogenic activity, in lean NAFLD and assessed their gut microbiota in relation to their equol-producing ability. Among 684 adult participants, 276 (40%) had NAFLD and 293 (43%) were equol producers. The rates of equol producers in the normal and NAFLD groups were 43% and 42%, respectively. Among the patients with NAFLD, 55 (20%) had lean NAFLD of which 18 (33%) were equol producers. The rate of equol production in men with lean NAFLD was 8%, which was the lowest, while the corresponding rate in the other participants was approximately 40%. The gut microbiota composition of equol producers and nonproducers showed many significant differences. The gut microbiota of men with lean NAFLD showed increased abundance of Caulobacter and decreased abundances of Slackia and Terrisporobacter. Thus, almost all men with lean NAFLD lacked equol-producing ability, and their gut microbiota showed a reduced abundance of Slackia, which is related to equol production. The pathology of lean NAFLD in men may be strongly associated with equol-producing ability and gut microbiota.
How We Get Free: Graduate Training as an Opportunity for Equitable Participation and Liberation
Authors: Volpe Vanessa V. , Hope Elan C. , Mosley Della V. , Javidi Hannah , Sosoo Effua E. , Benson G. Perusi
Published: August 2022

In this conceptual article, we assert that psychology should be transformed to adopt the explicit goal of working toward the liberation of people oppressed by society rather than striving for mere equality. To achieve such a transformation, it is necessary to reenvision graduate training in psychology. Graduate training in psychology is an important vehicle by which psychologists can become prepared to use research and practice to eradicate inequities in society. Therefore, we propose six pillars for liberation-focused graduate training in psychology: critical unlearning/unknowing, cooperative modes of production, prioritizing indigenous knowledge, embedded interdependence, systems-level action, and prioritizing members of oppressed groups. Although this conceptualization may engender resistance, we argue that there are many potential pathways by which graduate training may use liberation psychology to work equitably with oppressed groups to seek justice.
Screening Traditional Chinese Medicine Combination for Co-Treatment of Alzheimer's Disease and Major Depressive Disorder by Network Pharmacology
Authors: Huang Zhao-han , Fang Yuan , Wang Xiao-lu , Wang Qi , Wang Tong
Published: August 2022

Background: Due to their close relationship, the efficacy of major depressive disorder (MDD) drugs in the treatment of Alzheimer's disease (AD) has received widespread attention in recent years. Methods: In this study, we explored the potential therapeutic value of traditional Chinese medicine (TCM) and multitarget components on both MDD and AD by using a comprehensive strategy with network pharmacology and molecular docking technology. Results: In total, 234 MDD-related TCM prescriptions were analyzed and the 10 most commonly used Chinese herbs, correlating to 198 active ingredients, were identified. Through a comparative analysis of 144 prospective ingredient targets, 1095 MDD-related targets, and 1684 AD-related targets, network pharmacology identified 30 common targets, 9 key targets, and 7 representative compounds. The results of GO and KEGG enrichment analysis revealed that common targets were required to regulate multiple pathways related to MDD and AD. In addition, network analysis demonstrated that the combination of Xiangfu (Cyperi Rhizoma)-Gancao (Licorice)-Chaihu (Radix Bupleuri) constituted the major part of the representative ingredients and could be used to treat both diseases. Moreover, ALB, AKT1, ESR1, CASP3, and NOS3 were also chosen as prospective targets for synthetic multitarget ingredient screening. Further docking studies revealed that various natural chemicals exhibited binding affinity with the 5 targets, including quercetin, kaempferol, β-sitosterol, stigmasterol, isorhamnetin, naringenin, and 8-isopentenyl-kaempferol. Conclusion: Taken as a whole, the current study indicates a TCM combination with positive advantages in the combined treatment of AD and MDD.
Jugular Foramen Syndrome Caused by Varicella Zoster Virus Infection
Authors: Adjepong Kwame O. , LaHue Sara C. , Ha Deborah , Holmes Brandon B.
Published: August 2022

Jugular foramen syndrome (JFS) is a lower cranial neuropathy syndrome characterized by dysphonia and dysphagia. The syndrome is caused by dysfunction of the glossopharyngeal, vagus, and spinal accessory nerves at the level of the pars nervosa and pars vascularis within the jugular foramen. There are numerous etiologies for JFS, including malignancy, trauma, vascular, and infection. Here, we present the case of a healthy adult man who developed JFS secondary to an atypical presentation of Varicella Zoster meningitis, and was promptly diagnosed and treated with rapid symptom resolution. We diagnosed the patient using specialized skull-based imaging which detailed the jugular foramen, as well as CSF analysis. This case highlights the clinical value of detailed structural evaluation, consideration for infection in the absence of systemic symptoms, and favorable outcomes following early identification and treatment.
Blind sports’ blind spot: The global epidemiology of visual impairment against participation trends in elite blind para sport
Authors: Stratton Catherine S M , Fagher Kristina , Li Xiang , Ottesen Taylor D , Tuakli-Wosornu Yetsa A
Published: August 2022

Background: It remains unknown whether access to elite blind sports opportunities is globally balanced or matches the prevalence of blindness/visual impairment (VI). The primary objective of this study was to determine the rate of elite blind sports participation in each world region registered in the International Blind Sports Federation’s (IBSA) and to assess its association with the global and regional prevalence of blindness/VI. The secondary objective was to determine the association between other covariates, such as age, vision class, and sex, with the number of IBSA-registered athletes from each region.

Methods: A baseline estimate of blindness/VI data was established and used when comparing participation rates to blindness/VI rates. Descriptive statistics were used to describe sports participation and associated co-variates.

Results: Among 123 member countries registered in IBSA, 31 did not have any completed registrations in blind sports, of which 22 had a prevalence of blindness/VI higher than the global average. During the summer season 2019, 738 (29.52%) IBSA athletes were female and 1762 (70.48%) were male.

Conclusions: These results suggest elite blind/VI sport participation is limited independently from blindness/VI prevalence. Increasing blind-friendly sport resources, especially in low-and-middle-income countries (LMICs), would improve the rate of elite sport participation among athletes with blindness/VI.
Caregiver Singing Intervention: Do Expressions of Emotion and Resistance Differ Between Persons with Vascular Dementia and Those with Alzheimer’s Disease? A Pilot Study
Authors: Hammar Lena Marmstål , Wickberg Sanne Messelt , Skogsbäck Marie , Engström Gabriella
Published: August 2022

Background: The music intervention caregiver singing (CS) has been shown to be beneficial in facilitating care of persons with dementia in residential care, but no studies have focused on possible differences with respect to dementia diagnosis, which might be important due to possible different symptoms. Aim: To describe expressed emotions and resistiveness to care among persons with vascular dementia or Alzheimer’s disease during CS. Method: The study is a pilot intervention of CS which contains pre- and intervention measurements. Participants were persons with vascular dementia or Alzheimer’s disease. Measures were the Resistiveness to Care Scale and the Observed Emotion Rating Scale. Care situations without and with CS were compared of persons with vascular dementia and Alzheimer’s disease. The data are described with descriptive statistics. Results: During CS, positive emotion increased for persons with Alzheimer’s disease and vascular disease, with far longer intervals observed among persons with Alzheimer’s disease. Conclusion: CS may have positive influences regardless of diagnosis, but when targeting different emotional expressions, diagnosis may play an important role. However, larger studies need to be undertaken to confirm the results of this pilot study.
The Effect of Marketing Ethics as a Moderator on the Relationship Between Competitor Orientation and SMEs’ Performance in Saudi Arabia
Authors: Saleh Moad Hamod , Al-Hakimi Mohammed A.
Published: August 2022

This study seeks to investigate the impact of competitor orientation (CO) on SMEs’ performance in the manufacturing sector in Saudi Arabia. As well as to demonstrate how marketing ethics (ME) moderates this important relationship. Based on a sample of 408 Saudi manufacturing SMEs, and by PLS-SEM, the links in the proposed model were investigated. The obtained results revealed that actually, CO positively affects SMEs’ performance; more importantly, this effect is conditioned by ME. The findings of this study provide advantageous insights for managers and decision-makers for SMEs, as it is expected that they demonstrate a greater commitment to practicing ME in their firms. This has ramifications in that, with the practice of ME, it is predicted that SMEs will be able to fully exploit the potential of CO to increase their overall performance.
An Exploration of the Contingency Influence on Chinese Customers’ Selection of Online Hotel Reservation Channels
Authors: Yang Yang , Kim Jin-Hoo
Published: August 2022

Hotel companies have tried to sell rooms through their direct online reservation channels, but consumers still purchase a substantial number of rooms through indirect channels operated by online travel agencies (OTAs). This study explores when and under what circumstances consumers choose either a hotel channel or an OTA channel drawing on the theoretical frameworks of tourist information search strategy. Results reveal that travelers who book the hotels for business purposes, who have visited the destination before, and who are more familiar with the destinations and hotels seem to be more likely to choose hotels’ direct online reservation channels. These findings provide novel perspectives on understanding why hotel customers prefer one channel to another. Hotel managers could use the findings of this study to increase reservations through direct channels.
Emerging Adults’ Exposure to and Postings About Substance Use on Social Media: An Observational Study
Authors: Burnell Kaitlyn , Andrade Fernanda C. , Hoyle Rick H.
Published: August 2022

In a community sample of emerging adults ( N = 232), this study (a) assessed participants’ exposure to and postings about alcohol, cigarettes, e-cigarettes, and marijuana across social media platforms, (b) investigated how exposure to and posting about text versus visual substance-related content differentially relate to one’s own use, and (c) tested if exposure to versus posting about substances differentially relate to use. Data were collected via cross-sectional, daily, and observational methods. Participants were frequently exposed to substances on social media. Postings were less common, with Snapchat a notable outlet. Visual posts were somewhat more prominently linked to one’s own use than text posts. Posting about substances tended to be more strongly associated with own use than exposure, but this did not necessarily replicate with observed assessments. Social media platforms are key for emerging adults to encounter and post about substance use content, with implications for emerging adults’ own substance use.
Irreversibility process analysis for SiO2-MoS2/water-based flow over a rotating and stretching cylinder
Authors: Khan Masood , Sarfraz Mahnoor , Mehmood Sabba , Ullah Malik Zaka
Published: August 2022

Entropy is the measure of the amount of energy in any physical system that is not accessible for the useful work, which causes a decrease in a system’s thermodynamic efficiency. The idea of entropy generation analysis plays a vital role in characterizing the evolution of thermal processes and minimizing the impending loss of available mechanical power in thermo-fluid systems from an analytical perspective. It has a wide range of applications in biological, information, and engineering systems, such as transportation, telecommunication, and rate processes. The analysis of the entropy generation of axisymmetric magnetohydrodynamic hybrid nanofluid [Formula: see text]/water flow induced by rotating and stretching cylinder in the presence of heat radiation, ohmic heating, and the magnetic field is focus of this study. Thermal energy transport of hybrid nanofluids is performed by applying the Maxwell model. Heat transport is carried out by using convective boundary condition. The dimensionless ordinary differential equations are acquired by similarity transformations. The numerical solution for these differential equations is obtained by the bvp4c program in MATLAB. A comparison between nanofluid and hybrid nanofluid is made for flow field, temperature, and entropy generation. Comparison of nanofluid flow with hybrid nanofluid flow exhibits a higher rate of heat transmission, while entropy generation exhibits the opposite behavior. It is observed that the flow and heat distribution increase as the solid volume fraction’s value grows. An increase in entropy is indicated by augmentation in the Brinkman number and temperature ratio parameter, but the Bejan number shows a declining trend. Furthermore, outcomes of the Nusselt number for hybrid nanofluid and nanofluid are calculated for various parameters. It is noticed that the Nusselt number is reduced for enlarging the magnetic field and Eckert number. The axial and azimuthal wall stress parameters are declined by augmenting the Reynolds number.
Preoperative Medial Tightness and Narrow Medial Joint Space Are Predictive Factors for Lower Extremity Alignment Change Toward Varus After Opening-Wedge High Tibial Osteotomy
Authors: Lee Sung-Sahn , Lee Young Keun , Kim Il Su , Ryu Dong Jin , Jung Eui Yub , Lee Do Kyung , Wang Joon Ho
Published: August 2022

Background:

Time-dependent changes in lower extremity alignment after an opening-wedge high tibial osteotomy (OWHTO) have been poorly investigated. Moreover, few studies have investigated risk factors of postoperative alignment change.

Purposes:

To investigate time-dependent alignment changes and identify predictive factors for postoperative alignment change after OWHTO.

Study Design:

Case-control study; Level of evidence, 3.

Methods:

This study included patients who underwent OWHTO between March 2010 and September 2018. A total of 142 knees with a mean follow-up of 42 months were included and classified as the change group when the amount of hip-knee-ankle (HKA) angle change was >1°; if otherwise, then as the no-change group. HKA angle was obtained at 6 time points: preoperatively and at 3 months, 6 months, 1 year, 2 years, and final follow-up postoperatively. Multiple regression analysis was performed to identify the factors that were correlated with the changes in the HKA angle from 3 months to the final follow-up.

Results:

Among the 142 knees, 59 (42%) were included in the change group. The overall postoperative HKA angles progressed serially toward varus after OWHTO. The mean angles of the 6 time points were 8.5°, –3.7°, –3.6°, –3.3°, –3.1°, and –2.7°, respectively. The mean HKA angles of the change and no-change groups were 9.1°, –4.3°, –3.4°, –2.8°, –2.0°, and –1.4° and 8.1°, –3.3°, –3.8°, –3.6°, –3.8°, and –3.7°, respectively. Greater change in the HKA angle was predicted by preoperatively greater valgus stress joint line convergence angles and less medial joint space width.

Conclusion:

Of the cases of OWHTO, 42% showed correction loss of >1° at a mean follow-up of 42 months. The overall postoperative HKA angles progressed serially to varus angles after OWHTO. Preoperative greater valgus stress joint line convergence angles and less medial joint space width were predictive factors for greater change in alignment toward varus after OWHTO.
Misunderstanding Misunderstanding: Exploring the Depth of Hindrance to Cross-Cultural Communications
Authors: Beech Geoff
Published: August 2022

Those who have endeavored to engage cross-culturally understand that the process is neither simple nor straightforward. Apart from the obvious problems associated with understanding and misunderstanding a different language, at times we fall into the trap of not comprehending the real depth of our cultural misunderstanding, which in turn inhibits our engagement with those in the other culture and the effectiveness of our ministries. This article examines some of the deeper aspects of engagement relating to alterity, relational directionality, occupied “spaces,” pretheoretical assumptions, and the fusion of horizons of understanding.
Finite Element Analysis of Compression Behaviors of Silicone Rubber Composites Reinforced by Warp-Knitted Spacer Fabrics
Authors: Zhou Zi-xiang , Chen Si
Published: August 2022

In this study, the compression behaviors of silicone rubber composites reinforced by warp-knitted spacer fabrics under 20% deformation were investigated by experiment and a finite element analysis method. Based on the compression test, including the compression tests of composites and the warp-knitted spacer fabrics, the compression behaviors of composites were investigated. This revealed that the composites exhibited excellent elastic recovery abilities. Furthermore, the finite element analysis model of composites was established based on the parameters of the geometry and performance of the composites. The simulated results by the finite element analysis model were compared with the experimental ones to verify the accuracy of the model. It is obvious that the compressive finite element analysis model had good agreement with the experimental results, indicating that the compression performance of composites can be effectively simulated by the finite element analysis method. It is a useful tool for understanding the compression mechanism of composites and optimizing the composites’ parameters for cushioning applications.
Cross-Sectional Analysis of Foot and Ankle Questions on the Orthopaedic In-Training Examination: A Guide for Resident Preparation
Authors: Klein Brandon , Giordano Joshua , Barmann Jacob , White Peter B. , Cohn Randy M. , Bitterman Adam D.
Published: August 2022

Background:

The Orthopaedic In-Training Examination (OITE) is a standardized examination administered annually to orthopaedic surgery residents. The examination is designed to evaluate resident knowledge and academic performance of residency programs.

Methods:

All OITE foot and ankle questions from 2009 through 2012 and 2017 through 2020 were analyzed. Subtopics, taxonomy, references, and use of imaging modalities were recorded.

Results:

There were a total of 167 foot and ankle (F&A)–related questions across 8 years of OITE examinations. Trauma remained the most commonly tested subtopic of F&A across both subsets, followed by rehabilitation, tendon disorders, and arthritis. We found an increase in questions related to arthritis ( P = .05) and a decrease of questions related to the diabetic foot ( P = .02). Taxonomy 3 questions constituted 49.5% of F&A questions from 2009 through 2012 compared with 44.7% of questions from 2017 to 2020 ( P = .54). Radiography was the most commonly used imaging modality in both subsets. From 2009 to 2012, 63.6% of questions included a radiograph compared with 76.5% in 2017 through 2020 ( P = .13). FAI ( Foot & Ankle International), JAAOS ( Journal of the American Academy of Orthopaedic Surgeons), and JBJS ( The Journal of Bone and Joint Surgery) were the most commonly cited journals, making up more than 50% of total citations. Citations per question increased from 2.20 to 2.42 from 2009-2012 to 2017-2020 ( P = .01). The average lag time in the early subset was 8.2 years and 8.9 years in the later subset.

Conclusion:

This study provides a detailed analysis of the F&A section of the OITE. Use of this analysis can provide residents with a guide on how to better prepare for the OITE examination.

Level of Evidence:

Level IV, cross-sectional review of Orthopaedic In-Training Examination questions
Impact of the Health-Smart Holistic Health Program: A CBPR Approach to Improve Health and Prevent Adverse Outcomes for Black Older Adults
Authors: Tucker Carolyn M. , Wippold Guillermo M. , Roncoroni Julia , Henry Meagan A. , Klein Kirsten G. , Garrepy Matthew , Ateyah Wafaa , Burwell Alexanderia , Walker Hermonyone , Clements Leslie M. , Kelly Pryor Brandy N. , Fullwood Dottington
Published: August 2022

Black older adults experience poorer health and health-related outcomes than their non-Hispanic White counterparts. Novel, tailored strategies to promote health and prevent adverse health-related outcomes that are aligned with the preferences and values of Black older adults are needed given the limited effectiveness of “one-size-fits-all” approaches. The present study evaluated the impact of a 9-week, community-based participatory research-informed program called the Health-Smart Holistic Health Program for Seniors that aimed to improve health and prevent adverse outcomes among Black older adults by targeting body mass index (BMI), loneliness, food insecurity, and physical and psychological health-related quality of life. Participants ( N = 139) were community dwelling, economically disadvantaged Black older adults living in an underserved area. Results indicated that from pre-intervention to post-intervention there were (a) significant decreases in BMI, loneliness, and food insecurity and (b) significant increases in the participating seniors’ psychological and physical health-related quality of life. Most of these changes were maintained at a 3-month post-intervention follow-up. These results have implications for similar efforts attempting to prevent adverse health outcomes among Black older adults, a high-risk and understudied group. Such efforts should be tailored and should address factors at multiple levels.
Prolonged XPO1 inhibition is essential for optimal antileukemic activity in NPM1-mutated AML
Authors: Pianigiani Giulia , Gagliardi Andrea , Mezzasoma Federica , Rocchio Francesca , Tini Valentina , Bigerna Barbara , Sportoletti Paolo , Caruso Simona , Marra Andrea , Peruzzi Sara , Petito Eleonora , Spinozzi Giulio , Shacham Sharon , Landesman Yosef , Quintarelli Concetta , Gresele Paolo , Locatelli Franco , Martelli Maria Paola , Falini Brunangelo , Brunetti Lorenzo
Published: August 2022

NPM1 is the most frequently mutated gene in adults with acute myeloid leukemia (AML). The interaction between mutant NPM1 (NPM1c) and exportin-1 (XPO1) causes aberrant cytoplasmic dislocation of NPM1c and promotes the high expression of homeobox (HOX) genes, which is critical for maintaining the leukemic state of NPM1-mutated cells. Although there is a rationale for using XPO1 inhibitors in NPM1-mutated AML, selinexor administered once or twice per week did not translate into clinical benefit in patients with NPM1 mutations. Here, we show that this dosing strategy results in only a temporary disruption of the XPO1-NPM1c interaction, limiting the efficacy of selinexor. Because the second-generation XPO1 inhibitor eltanexor can be administered more frequently, we tested the antileukemic activity of prolonged XPO1 inhibition in NPM1-mutated AML models. Eltanexor caused irreversible HOX downregulation, induced terminal AML differentiation, and prolonged the survival of leukemic mice. This study provides essential information for the appropriate design of clinical trials with XPO1 inhibitors in NPM1-mutated AML.
Demethylation and tannin-like properties of guaiacyl/syringyl-type and syringyl-type dehydrogenation polymers using iodocyclohexane
Authors: Kobayashi Tokimitsu , Tobimatsu Yuki , Kamitakahara Hiroshi , Takano Toshiyuki
Published: August 2022

The demethylation of guaiacyl/syringyl (G/S)-type (G/S = 1/1) and syringyl (S)-type dehydrogenation polymers (DHPs) using iodocyclohexane (ICH) under reflux in DMF was performed to afford demethylated G/S- and S-DHPs in moderate yields. Along with significant structural changes, such as side-chain cleavage and recondensation, as observed using heteronuclear single quantum coherence (HSQC) NMR spectra, the phenolic-OH content of the demethylated DHPs increased, as expected. The tannin-like properties, such as the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging ability, iron(III) binding ability, and bovine serum albumin (BSA) adsorption ability, of the demethylated DHPs increased with increasing reaction time. In particular, the BSA adsorption ability was significantly enhanced by demethylation of the G/S- and S-DHPs, and was better than that of G-DHP reported previously. These results indicate that hardwood lignin containing both G and S units is more suitable than softwood lignin containing only G units for functionalization through demethylation into a tannin-like polymer, which has applications as a natural oxidant, metal adsorbent, and protein adsorbent.
Evaluation of vicinity-based hidden Markov models for genotype imputation
Authors: Wang Su , Kim Miran , Jiang Xiaoqian , Harmanci Arif Ozgun
Published: August 2022

Background

The decreasing cost of DNA sequencing has led to a great increase in our knowledge about genetic variation. While population-scale projects bring important insight into genotype–phenotype relationships, the cost of performing whole-genome sequencing on large samples is still prohibitive. In-silico genotype imputation coupled with genotyping-by-arrays is a cost-effective and accurate alternative for genotyping of common and uncommon variants. Imputation methods compare the genotypes of the typed variants with the large population-specific reference panels and estimate the genotypes of untyped variants by making use of the linkage disequilibrium patterns. Most accurate imputation methods are based on the Li–Stephens hidden Markov model, HMM, that treats the sequence of each chromosome as a mosaic of the haplotypes from the reference panel.

Results

Here we assess the accuracy of vicinity-based HMMs, where each untyped variant is imputed using the typed variants in a small window around itself (as small as 1 centimorgan). Locality-based imputation is used recently by machine learning-based genotype imputation approaches. We assess how the parameters of the vicinity-based HMMs impact the imputation accuracy in a comprehensive set of benchmarks and show that vicinity-based HMMs can accurately impute common and uncommon variants.

Conclusions

Our results indicate that locality-based imputation models can be effectively used for genotype imputation. The parameter settings that we identified can be used in future methods and vicinity-based HMMs can be used for re-structuring and parallelizing new imputation methods. The source code for the vicinity-based HMM implementations is publicly available athttps://github.com/harmancilab/LoHaMMer.
Proteome-wide analysis of lysine 2-hydroxyisobutyrylation in Frankliniella occidentalis
Authors: Ding Chengying , Song Liyun , Li Ying , Shen Lili , Liu Dongyang , Wang Fenglong , Lin Zhonglong , Yang Jinguang
Published: August 2022

Background

Lysine 2-hydroxyisobutyrylation (Khib) is a novel and conserved post-translational modification (PTM). Frankliniella occidentalis are economically important agricultural pests globally and also notorious for vectoring destructive plant viruses. To better study the disease transmission mechanism of F. occidentalis, it is necessary to conduct in-depth analysis of it. So far, no Khib modification of insects has been reported.

Results

In this study, a proteome-wide analysis of Khib modifications in F. occidentalis was analyzed for the first time through the combination of high performance liquid chromatography fractionation technology and 2-hydroxyisobutyrylated peptide enrichment and other advanced technologies, 4093 Khib sites were identified on 1125 modified proteins. Bioinformatics and functional enrichment analyses showed that Khib-modified proteins were significantly enriched in many cell compartments and pathways, especially related to various cellular components and biological processes, and were more concentrated in ribosomes and proteasome subunits, involved in energy metabolism, protein synthesis and degradation, compared to the other nine species including Japonica rice, Homo sapiens, P. patens, Botrytis, Ustilaginoidea virens, Saccharomyces cerevisiae, T. gondii, C. albicans, and F. oxysporum. And Khib sites on virus-interacting insect proteins were discovered for the first time, such as cyclophilin and endoCP-GN.

Conclusions

After three repeated experiments, we found a total of 4093 Khib sites on 1125 proteins. These modified proteins are mainly concentrated in ribosomes and proteasome subunits, and are widely involved in a variety of critical biological activities and metabolic processes of F. occidentalis. In addition, for the first time, Khib modification sites are found on the proteome of F. occidentalis, and these sites could be acted as for the virus interaction, including cyclophilin and endoCP-GN. The global map of 2-hydroxyisobutyrylation in thrips is an invaluable resource to better understand the biological processes of thrips and provide new means for disease control and mitigation of pest damage to crops.
Reference values of gait characteristics in community-dwelling older persons with different physical functional levels
Authors: Dapp Ulrike , Vinyard Dominic , Golgert Stefan , Krumpoch Sebastian , Freiberger Ellen
Published: August 2022

Background

Mobility is one major component of healthy ageing of older persons. It includes gait speed, nowadays valued as the sixth vital sign of ageing. Quantitative gait analysis can support clinical diagnostics, monitor progression of diseases and provide information about the efficacy of interventions. Fast gait speed is an additional marker in the area of functional ability. Our aim was to contribute reference values of gait parameters of older persons based on their functional ability.

Methods

We visualised and combined three different established frameworks that assess gait characteristics into a new framework based approach that comprises eight gait parameters: gait speed, stride length, walk ratio, single and double support time, step width, step width CV (coefficient of variance), stride length CV. Gait parameters were stratified by two instruments that indicate levels of functional ability: First, the LUCAS Functional Ability Index (FAI), a self-administered screening tool easy to apply to a public-health orientated approach and second the Short Physical Performance Battery (SPPB), an established performance test widely used in comprehensive geriatric assessments (CGA). Gait parameters of older community-dwelling persons were measured with an objective Gait system (GAITRite) across differing functional ability ranging from robust to transient (postrobust and prefrail) to frail physical status.

Results

Of 642 community-dwelling participants (age 78.5 ± 4.8; n = 233 male, n = 409 female) categorisations by SPPB were 27.1% for robust (11–12 points), 44.2% for transient (8–10 points), 28.7% for frail (0–7 points), and 16.2, 50.3, 33.5% for robust, transient, frail by LUCAS FAI. Overall, our results showed that distinction by functional level only uncovers a wide spectrum of functional decline for all investigated gait parameters. Stratification by functional ability (biological age) revealed a greater range of differentiation than chronological age.

Conclusions

Gait parameters, carefully selected by literature, showed clinically meaningful differences between the functional featuring a gradient declining from robust over transient to frail in most gait parameters. We found discriminative power of stratifications by SPPB to be the highest, closely followed by LUCAS FAI, age groups and dichotomous age making the application of the LUCAS FAI more cost and time effective than conducting SPPB.