bluuebunny/crossref_metadata_2025 huggingface dataset:
Open-label, Non-controlled Study of Lokivetmab in Atopic Dogs in Brazil
Authors: Campos Millena Leme , Lucas Ronaldo , Moraes-Filho Jonas , de Marco Viviani , Lopes Jessica Dinelli , Beviani Daniela , Pelegrini Carla , Cunha Vitoria Miranda Camarrão
Published: January 2023

Background
The subcutaneous injection of lokivetmab at day zero at the labeled dose range of 2mg/kg was evaluated in 106 dogs recruited from two private clinics in the State of São Paulo, Brazil. The objective of this 30-day open-label, non-controlled study was to evaluate the level of improvement in cases of canine Atopic Dermatitis (cAD) using the Canine atopic dermatitis extent and severity index (CADESI-4), Visual analogue scale (VAS) of pruritus, the incidence of adverse events, and owner’s perception of the treatment response by Global assessment of efficacy (OGATE).
Results
Baseline mean VAS of pruritus was 7.75 (median = 7), decreasing to 3.86 (median = 2) at day 2 ( p < 0.001). CADESI-4 scores decreased from 36.65 at baseline to 16.47 at day 30 (p < 0.001). Reports of treatment responses submitted by owners and evaluation of CADESI-4 after treatment were significantly similar (p < 0.001). Owners rated the response to treatment as good to excellent for 73,5% of the dogs. Adverse events, including vomiting, diarrhea, and/or lethargy, were observed in 18 dogs (17%). All events were transient, and none required treatment.
Conclusions
Based on findings in this study, lokivetmab was determined to provide a rapid and effective response for control of cAD. Lokivetmab was well tolerated with only mild and transient adverse events observed.
Natural Resource Use Conflict and Its Management in Babile Elephant Sanctuary, Eastern Ethiopia
Authors: Tekletsadik Shimelis , Kebede Fanuel , Degefa Sileshi
Published: January 2023

Babile Elephant sanctuary (BES) is located in the semi-arid ecosystemin eastern part of Ethiopia. Natural resource use conflict is one of the major problems of the sanctuary. This study aimed at assesing the root causes of conflicts and their impacts on the sanctuary. Data was collected through satellite imagery,household survey, focus group discussions and key informat interviews. Land use/land cover change analyses were made for a period of three decades (1990-2020). The study indicated a significant changes on the drivers of resource use conflict of the Kebeles (p<0.05). The satellite image analyses revealed forest and grassland have been decreased whereas bare land, settlement, cultivated and bush lands have increased.
The current resource use conflict and change in the land use can be mitigated through boundary re-demarcation of the sanctuary and creation of alternative means of community livelihoods in collaboration with the concerned stakeholders along with law enforcement and community engagements.
Somatic Mutations within Myocilin due to Aging may be a Potential Risk Factor for Glaucoma.
Authors: Sazhnyev Yevgeniy , Venkat Akaash , Zheng Jie
Published: January 2023

Glaucoma is a chronic optic neuropathy that leads to irreversible vision loss. Aging and family history are the two most important risk factors of glaucoma. One of the most studied genes involved with the onset of open angle glaucoma is myocilin (MYOC). About 105 germline mutations within MYOC are known to be associated with glaucoma and result in endoplasmic reticulum (ER) stress that leads to trabecular meshwork (TM) cell death and subsequent intraocular pressure (IOP) elevation. However, only about 4% of the population carry those mutations. An analysis of MYOC somatic cancer-associated mutations revealed a notable overlap with pathogenic glaucoma variants. Because TM cells have the potential to accumulate somatic mutations at a rapid rate due to ultraviolet (UV) light exposure, we propose that an accumulation of somatic mutations within MYOC is an important contributor to the onset of glaucoma.
Osteogenesis Capability of Gelatin-based biomimetic Scaffold containing PRP-loaded Starch Nanoparticles
Authors: Boraei Seyyed Behnam Abdollahi , Nourmohammadi Jhamak , Shokrollahi Saeideh , Seyedjafari Ehsan
Published: January 2023

A new generation of scaffolds capable of acting not only as support for cells but also as a source of biological cues to promote tissue regeneration is currently a hot topic in bone Tissue Engineering (TE) research. The controlled release of the Growth Factors (GFs) from the scaffolds is a suitable strategy to achieve such a goal. Platelet Rich Plasma (PRP) is an autologous source of GFs, providing several bioactive agents known to act on bone regeneration. In this study, citric acid-modified starch nanoparticles loaded with PRP will be included in a gelatin scaffold. Scaffolds were evaluated in vitro with respect to compressive strength, water uptake, and protein release. The size of the pores in the production scaffolds was evaluated to be around 150 microns which is suitable for bone regeneration. The scaffolds were then seeded with human adipose-derived stem cells (hASCs) and cultured in vitro. The osteogenic behavior of the seeded hASCs was evaluated by alkaline phosphatase activity (ALP activity) and calcium assay analysis. The results show the promotion of morphological, mechanical, and biological properties of the scaffolds by adding PRP-loaded nanoparticles. Our results suggest that the PRP-loaded starch nanoparticles enhance the biological and bone regeneration of the gelatin-based scaffolds.
Effect of Rosemary Essential Oil Oral Supplementation on Testes Morphometric Measures, Accessory Genital Glands, and Semen Parameters in the Barki Rams
Authors: Ali Montaser Elsayed , Zainhom Mohammed , Monier Ahmed , Awad Ahmed
Published: January 2023

The present study investigated the effect of the Rosemary essential oil oral Supplementation on the development of the reproductive organs, including morphometric measures, accessory genital gland, and semen quality in Barki rams. Sixty rams were randomly divided into two equal groups; control (G1) and Rosemary essential oil (G2), treated with 2 mg/Kg of body weight per day for 45 days treated group. Ultrasonographic measurements and blood sampling were performed on days 15, 30, and 45 of the treatment, and semen samples were collected twice a week after 15 days for quantitative and qualitative analysis. The results showed a significant increase in the testicular parameter measures and epididymal tail in the Rosemary group than in the control group. However, the seminal vesicle, Cowper's, and prostate glands showed the highest development on day 45 of the treatment. Although there was a significant increase in the ejaculate volume (ml), individual motility (%), and sperm cell concentration (x109/ml) in Rosemary treated group than the control group; there was no significant improvement (P > 0.01) in the alive spermatozoa (%). Furthermore, the treatment showed a positive effect on testosterone levels, testicular measures, epididymal tail, accessory genital gland, individual sperm motility, and viability. The present result revealed that oral supplementation with Rosemary essential oil might improve testicular parameters, accessory genital glands, and semen quality.
Antibiotic-free Helicobacter pylori eradication – case reports and review of the literature
Authors: Bahadori Babak , Tonninger-Bahadori Katayoun , Nekrep Karl
Published: January 2023

Background: Standard Helicobacter pylori eradication therapy is based on proton pump inhibitors and antibiotics. There are, however, important limitations: increasing antibiotic resistance of Helicobacter pylori, medical contraindications, and an increasing unwillingness among patients to use antibiotics.
Case presentations: We present three exemplary case reports of successful antibiotic-free Helicobacter pylorieradication therapies, one for each of these limiting categories: a 61-year-old female Caucasian patient refractory to prior eradication therapy, an 80-year-old female Caucasian patient with contraindication to antibiotics, and a 41-year-old male Caucasian patient refusing antibiotics. A review of the literature attempts to provide a scientific rationale for proton pump inhibitor-based and probiotics-supported Helicobacter pylorieradication.
Conclusion: Antibiotics-free Helicobacter pylorieradication may offer a therapeutic option for patients in whom classical eradication therapy cannot be conducted or who are refractory to antibiotics. Clinical trials are needed to scientifically evaluate the concept presented here.
First Realization of Quantum Energy Teleportation on Quantum Hardware
Authors: Ikeda Kazuki
Published: January 2023

Teleporting physical quantities to remote locations is a remaining key challenge for quantum information science and technology. Quantum teleportation has enabled the transfer of quantum information, but teleportation of quantum physical quantities has not yet been realized. Here we report the first realization and observation of quantum energy teleportation on real quantum hardware. We achieve this by using several IBM’s superconducting quantum computers. The results are consistent with the exact solution of the theory and are improved by the mitigation of measurement error. Quantum energy teleportation requires only local operations and classical communication. Therefore our results provide a realistic benchmark that is fully achievable with current quantum computing and communication technologies.
Serum free light chains benefit diagnosis of multiple myeloma in orthopaedic patients with normal serum total proteins, creatinine, calcium and hemoglobin
Authors: Jia Zhongwei , Xia Jinxing , Lu Qiong
Published: January 2023

Background:

A substantial number of MM patients with bone destruction are initially admitted into Orthopedics due to bone pain. However, routine laboratory tests usually fail to identify these patients and delay optimal therapy. Therefore, there is a clear medical need in early diagnose MM on these patient population.

Methods

Ninety-four orthopaedic patients were enrolled from July 2019 to December 2021. Of them, 42 patients were diagnosed as MM during postoperative pathology, but exhibited normal serum total proteins, creatinine, calcium and hemoglobin before operation. The rest 52 orthopaedic patients were pathologically excluded from MM and recruited into control group. The immunofixation electrophoresis (IFE) assays were performed to detect sFLC levels of all the subjects for comprehensively analyzed.

Results

The sFLC κ/λ ratios in 37 out of 42 MM patients were outside the reference range (0.31 ~ 1.56). All 42 MM patients were divided into two groups based on sFLC, κ/λ ratio > 1 or κ/λ < 1 respectively. And there were no significant differences in levels of serum total proteins, creatinine, calcium and hemoglobin between these two groups and control group.

Conclusions

This study highlighted the clinical significance of sFLC detection in early diagnosis of MM in orthopedics patients with unexplained bone destruction, supporting appropriate treatment choices preoperatively.
The Comparison of Partial Hemivertebrae Resection versus Total Hemivertebrae Resection by posterior only approach with short-segment fixation in children with Congenital Scoliosis. A minimum of a 4-year follow-up study
Authors: Guo Chaofeng , Zhang HongQi , Alonge Emmanuel , Wang Yuxiang , Ang Deng , Liu ShaoHua
Published: January 2023

The series of complications involved in hemivertebra resection has not yet led to a precise solution. Therefore, we aim to compare less invasive, partial hemivertebra resection versus total hemivertebra resection for this anomaly in children with a long-term follow-up. From 2011 to 2016, we did a retrospective study on 31 patients with congenital scoliosis associated with hemivertebrae who had a posterior-only approach comprising 16 patients with total hemivertebrae resection (TR), 15 patients with partial hemivertebrae resection (PR), and short-segment fusion. There was 31 congenital scoliosis associated with hemivertebrae patients in both the PR and TR groups, and the average mean age at the time of surgery was 6.3 ± 2.0 and 6.0 ± 1.9, respectively. The PR group had an equipotential correction rate of cobb angle at post-operation (4.3 ± 4.9 and 2.2 ± 3.2, P = 0.174) and the last follow-up (8.3 ± 5.4 and 5.5 ± 2.4, P = 0.087) as the TR group. Partial hemivertebra resection is efficient and secure. A less invasive technique obtained an equivalent well-maintained correction rate to the total hemivertebra resection with a better quality of life outcome of the patients.
A Parallel Feature Selection Method Based on NMI-XGBoost and Distance Correlation for Typhoon Trajectory Prediction
Authors: Qiao Baiyou , Hao Yuanqing , Wang Rui , Wang Peirui , Han Donghong , Wu Gang
Published: January 2023

Typhoon trajectory related data involves many factors such as atmospheric factors, oceanic factors, and physical factors. It has the characteristics of high dimension, strong spatio-temporal correlation, and non-linear correlation, which increases the difficulty of typhoon trajectory prediction. Using feature selection approaches to select appropriate prediction factors becomes an important means to reduce the dimension of typhoon trajectory related data and improve the performance and accuracy of typhoon trajectory prediction methods. However, the existing feature selection methods based on linear correlation analysis can not well depict the nonlinear correlation between data features, which results in low accuracy of feature selection. The feature selection methods based on nonlinear correlation analysis are computationally expensive, which affects the timeliness of feature selection. To solve the problem, we propose a parallel feature selection method NX-Spark-DC based on the Spark platform for typhoon trajectory related data. The method firstly filters out the redundant features of typhoon related data by Normalized Mutual Information (NMI) method, subsequently eliminates the useless features by XGBoost machine learning model, and thus reducing the dimension of typhoon related data. On this basis, an improved Spark-based parallel distance correlation algorithm (Spark-DC) is proposed to select the feature combinations with strong correlation. A series of experimental results show that NX-Spark-DC method has high execution efficiency and accuracy, which is significantly better than the existing methods.
A Chinese Collaborative Model for Accelerating Neurofibromatosis Type 1-Associated Research
Authors: Chung Man-Hon , Li Yuehua , Wang Wei , Gu Yihui , Wei Chengjiang , Aimaier Rehanguli , Li Qingfeng , Wang Zhichao
Published: January 2023

Neurofibromatosis type 1 (NF1) is a genetic disorder that affects multiple organ systems. Establishing a multidisciplinary center becomes essential for NF1 management. This study aims to introduce the progress and patient characteristics of the largest NF1 center in China. We retrieved NF1 patient data from 2013 to 2021, including basic personal information, date and department of first admission, location of tumors, and number of re-admission. A total of 725 patients were enrolled in this study, with a mean age of 23.8 years old. Patients were primarily admitted at the age of adolescence and young adulthood. There was not much difference in the number of male and female patients, despite more male patients being observed in adolescence. Both marital and occupational status were negatively affected by the disease. The number of patients admitted each year revealed an increasing trend in general. Regarding deep-seated tumors, 77.6% occurred in the head and neck region, and 3.8% were NF1-associated MPNSTs. Almost a quarter of patients were re-admitted after the first admission, and the mean re-admission time interval was 1.5 years. In summary, we developed the largest multidisciplinary NF1 healthcare center in China, which enables Chinese NF1 patients to access more appropriate healthcare, thereby alleviating the socioeconomic burden of disease among patients.
Dynamic high-pressure microfluidization of pea dietary fiber: Modified structural and adsorption properties and interaction with chlorogenic acid
Authors: Ji Wei , Sheng Guihua , Nan Xijun , Wang Honglei , Li Jiayi , Zhou Quancheng
Published: January 2023

In this study, pea dietary fiber (PDF) was modified by dynamic high-pressure microfluidization (DHPM) technology with the aim to reveal the modulation of the structural and adsorption properties of PDF under different pressures. In addition, pea dietary fiber–chlorogenic acid complexes (PDF-CA) after DHPM treated were obtained, to further investigate the interaction between PDF and CA, and synergistic action of CA and DHPM on PDF. Due to the molecular interplay of PDF-CA, the results showed that PDF and PDF-CA samples with different particle sizes could be obtained after DHPM treatment. Microscopic evaluation of PDF and complexes also showed significant morphological changes; the crystallinity of both PDF and complexes decreased during the treatment, but the trend of thermal stability showed a different shift. In addition, the DHPM treatment made the samples exhibit better water- and oil-holding properties, enhanced their ability to bind glucose and cholesterol, and gradually enhanced the adsorption capacity with increasing pressure. These results illustrated that the structural and adsorption properties of PDF could be effectively modified by DHPM and CA.
Real-life evaluation of NIV to CPAP switch in patients with chronic respiratory failure. A case control study.
Authors: Mathieu Louise , Rabec Claudio , Beltramo Guillaume , Aho Ludwig S. , Tankere Pierre , Schenesse Déborah , Chorvoz Jade , Bonniaud Philippe , Georges Marjolaine
Published: January 2023

Background
Non-invasive ventilation (NIV) is a standard of care for hypercapnic chronic respiratory failure (CRF). Obstructive sleep apnea (OSA) frequently contribute to hypoventilation in CRF. CPAP improves hypercapnia in selected COPD and obese patients. We describe the profile of patients switching from NIV to CPAP in a cohort of patients on long-term NIV and identify factors associated with a successful switch.
Methods
The observational research protocol evaluation committee of the French Pneumology Society approved this case-control study (CEPRO 2022-015). We compared 88 consecutive candidates for a NIV-CPAP switch with 266 controls among 394 ventilated patients treated at the Dijon University Hospital between 2015 and 2020. They followed a standardized protocol including a poly(somno)graphy recorded after NIV withdrawal for three nights. CPAP trial was performed if severe OSA was confirmed. Recurrent hypoventilation was checked after one night and one month under CPAP.
Results
Patients were 53% males, median age 65 [56–74] years, and median BMI 34 [25-38.5] kg/m2. Sixty seven percent of patients were safely switched and remained on CPAP. The probability of a NIV-CPAP switch was correlated to older age (OR:1.3 [1.01–1.06]), CRF etiology (OR for COPD:20.37 [4.2–98,72], obesity:7.31 [1.58–33.74]), circumstances of NIV initiation (OR for acute exacerbation:11.64 [2.03–66.62]), lower pressure support (OR:0.90 [0.73–0.92]), lower baseline PaCO2 (OR:0.85 [0.80–0.91]) and lower compliance (OR:0.76 [0.64–0.90]). Pressure support level was the only factor associated with the outcome of the NIV-CPAP switch.
Conclusions
A NIV-CPAP switch is possible in real life conditions in stable obese and COPD patients with underlying OSA.
À la carte, Streptococcus pneumoniae capsular typing: using MALDI-TOF mass spectrometry and machine-learning algorithms as complementary tools for the determination of PCV13 serotypes and the most prevalent NON PCV13 serotypes according to Argentina’s epidemiology
Authors: Zintgraff Jonathan , Rocca Florencia , Eluchans Nahuel Sánchez , Irazu Lucía , Moscoloni Maria Luisa , Lara Claudia , Santos Mauricio
Published: January 2023

Laboratory surveillance of Streptococcus pneumoniae serotypes is crucial for the successful implementation of vaccines to prevent invasive pneumococcal diseases. The reference method of serotyping is the Quellung reaction, which is labor-intensive and expensive. In the last few years, the introduction of MALDI-TOF MS into the microbiology laboratory has been revolutionary. In brief, this new technology compares protein profiles by generating spectra based on the m/z ratio. We evaluated the performance of MALDI-TOF MS for typing serotypes of S. pneumoniae isolates included in the PCV13 vaccine using a machine learning approach. We challenged our classification algorithms in “real time” with a total of new 100 isolates of S. pneumoniae from Argentinian nationwide surveillance. Our best approach could correctly identify the isolates with a sensitivity of 58.33% ([95%IC 40.7–71.7]); specificity of 81.48% ([95%IC 53.6–79.7]); accuracy of 63.0% ([95%IC 61.9–93.7]); PPV of 80.77% ([95%IC 64.5–90.6]) and NPV of 59.46% ([95%IC 48.9–69.2]). In this work, it was possible to demonstrate that the combination of MALDI-TOF mass spectrometry and multivariate analysis allows the development of new strategies for the identification and characterization of Spn isolates of clinical importance.
Knowledge, Attitude and Practices with respect to Sports Nutrition of Elite Cricketers from India and Impact Evaluation of Nutrition Education Module
Authors: Deota Prachi , Chandorkar Suneeta
Published: January 2023

Purpose Basic sport-specific nutrition knowledge of an athlete can result in better nutrition-based choices. Therefore, it is imperative to explore the existing knowledge, practices and attitude of athletes toward Sports Nutrition and address the gaps if any.
Methods The study was conducted on elite cricketers (n=81; 54 males, 27 females) from urban Vadodara, India. The existing knowledge, attitude and practices of the athletes w.r.t sports nutrition were recorded by administering a semi-structured questionnaire. Based on the identified gaps, a nutrition education booklet was developed and distributed to the participants which was followed by daily reinforcement of the key messages for 21 days. The impact evaluation of the intervention was assessed after a washout period of 2 months.
Results Over 89.3% of the respondents indicated that nutrition support is critical in their sport and over 86.7% believed that a nutritionist should be a member of the sports professionals' team. Only about 21% of the participants consumed solid foods within the recommended period of 30 minutes after the match, which is the window of recovery. In all the squads the post-intervention knowledge scores improved compared to the pre-intervention scores (p=0.000). All the participants consumed some or the other form of supplements; Sports drinks were consumed by 96% of the participants, protein by 44% and BCAA by 3%.
Conclusion The key knowledge deficit areas of the cricketers at the baseline showed significant improvement post-intervention across all the 3 squads thus emphasising the need and benefit of nutrition education for athletes.
On generalized eigenvalue problems of fractional $(p,q)$-Laplace operator with two parameters
Authors: Biswas Nirjan , SK Firoj
Published: January 2023

For s1, s2 ∈ (0, 1) and p, q ∈ (1,∞), we study the following nonlinear Dirichlet eigenvalue
problem with parameters α, β ∈ R driven by the sum of two nonlocal operators:
(−Δ)s1p u + (−Δ)s2q u = α|u|p−2u + β|u|q−2u in Ω, u = 0 in Rd \ Ω,
where Ω ⊂ Rd is a bounded open set. Depending on the values of α, β, we investigate the existence and non-existence of positive solutions to the above problem. A continuous curve in the two-dimensional (α, β)-plane is constructed, which separates the regions of the existence and non-existence of positive solutions. In addition, we prove that the first Dirichlet eigenfunctions of the fractional p-Laplace and fractional q-Laplace operators are linearly independent.
Can paracetamol alter the reproduction regulatory axis of a male Neotropical catfish? A multibiomarker approach
Authors: Perussolo Maiara Carolina , Vicentini Maiara , Lyra Leonardo Skarbek , Silva Lucicleide Ângelo , Rodrigues Mayara dos Santos , Fernandes Leticia Pereira , Fávaro Luis Fernando , Assis Helena Cristina Silva
Published: January 2023

Paracetamol (PCM), or acetaminophen, is one of the most used drugs for human treatment and has been found contaminating the aquatic environment. Besides, it can affect the aquatic biota. The aim of this study was to investigate the effects of PCM in the male catfish Rhamdia quelen reproductive axis after 14 days of exposure. Different biomarkers were evaluated in hypothalamus, liver and gonads, as well as sexual hormone levels. The fish were exposed to solvent (acetone 0.0003%; control group) and to three PCM concentrations: 0.25, 2.5 and 25 µg.L-1, based on environmental concentrations. After the exposure period, they were anesthetized for blood sampling and biometrics and euthanized for tissues collection. From blood, it was obtained plasma for 11 – keto testosterone and 17β – estradiol hormones quantification. The hypothalamus was collected for brain aromatase (cyp19a1b) gene expression; the liver for the vitellogenin (vtg) gene expression and biochemical biomarkers; and gonad for the biochemical and histological biomarkers analyses. No alterations were observed in the hormones levels, sexual maturation or in cyp19a1b and vtg gene expression. In the liver, the non-protein thiols concentration and the superoxide dismutase (SOD) activity were altered. In gonads, glutathione S-transferase (GST), SOD and glutathione peroxidase (GPx) activities changed. The results showed that PCM environmental concentrations can cause alterations in the antioxidant system, mainly in the R. quelen male gonads under the tested conditions. However, no significant changes of hormones levels or the expression of genes related to the reproduction axis were observed.
Diagnostic Accuracy of Plain Computed Tomography (CT) to detect the Morphological Variations of Liver: An update
Authors: Muraleedharan Aparna , Ragavan Saranya , Nayakar Gopinath , Bage Nutan Nalini , Devi Rema , Phansalkar Dilip Shankar
Published: January 2023

Introduction
The prevalence of accessory fissures in the liver ranges from 6% - 56%, as reported by cadaveric studies, which is much higher than the prevalence of 25% on CT scans. Despite reporting many morphological variations in the liver by various cadaveric studies worldwide, the imaging studies are very few. Radiological imaging of patients undergoing liver surgery is a routine preoperative investigation. Despite there are several occasions where liver variations occur as a surprise during surgery which reflects on the diagnostic capacity of CT.
Materials & Methods
60 cadaveric livers removed and stored in 10% Formalin were studied for all morphological abnormalities. The same livers were analysed separately by anatomists using gross examination and radiologists using plain CT imaging. The radiologist reporting the CT findings was blinded from the gross examination findings. The data obtained by both methods were compared by using appropriate statistical methods and the diagnostic accuracy of CT was estimated.
Results
The common surface morphological variations detected were accessory fissures, accessory lobes, pons hepatis and multilobed caudate and quadrate lobes. Out of the total 89 accessory fissures identified by gross examination, only 73 could be detected by CT scan, thus the sensitivity of CT scan in detecting accessory fissures is 82%. Similarly, sensitivity of CT scan in detecting accessory lobes, pons hepatis, and multilobed caudate and quadrate lobe was calculated as 64% (low), 81% and 19% (very low) respectively. Thus, plain CT has variable sensitivity depending on the morphological variation.
Conclusions
This study has highlighted some of the diagnostic inaccuracies that may arise during plain CT examination of liver in a person posted for liver surgery or a person with abdominal trauma. Contrast-enhanced CT scans can circumvent many of these problems. Lack of awareness of these issues may affect the normal course of treatment and prognosis in such patients.
Demodex Prevalence in Mine, Textile and Food Factory Workers with Dermatosis: a cross‐sectional, multicenter study
Authors: Metin Zuhal , Akca Hanife Merve , Ozkoca Defne , Imren Isıl Gogem , Durmaz Koray , Kara Kevser Tuncer , Metin Mahmut Sami , Temiz Selami Aykut , Caf Nazli , Ozyurt Kemal
Published: January 2023

Demodex, a type of mite, lives in human hair follicles. They can multiply very quickly in some conditions and then start to irritate the skin by causing skin disorders. This study aims to compare if working conditions affect the workers' Demodex prevalence so their skin health. A cross-sectional, multicentre study was conducted with three different occupational groups: Mine, Textile and Food Factory Workers (n=102). Determined industry workers who applied to our outpatient dermatology clinics with the complaint of dermatosis in three different cities were included in the study. Demodex positivity was checked by dermoscopy. Differences between categorical variables examined with Chi-square analysis and T test was used to compare continuous variables between groups. 50% Demodex positivity was found in mine workers, %45,3 in food factory workers and 66,7% in textile manufacturing workers. A high rate of Demodex positivity was observed in all three occupational groups. Although the highest positivity rate was observed in textile manufacturing workers, no significant difference was found between the groups (p=0.320). The overall prevalence of Demodex in female workers was statistically significantly higher than in male workers (p=0.029). Exposure of workers to a wide variety of factors in work environments such as textile factories and the fact that women are more sensitive to external factors may have caused the prevalence of Demodex to be higher in these groups. So, a change in the work environment or the use of suitable protective equipment may benefit the treatment of diseases caused by Demodex. But, further studies are needed with larger and various industry groups to make more certain views.
Identification of molecular signatures and pathways involved in Rett syndrome using a multi-omics approach
Authors: Pascual-Alonso Ainhoa , Xiol Clara , Smirnov Dmitrii , Kopajtich Robert , Prokisch Holger , Armstrong# Judith
Published: January 2023

Background
Rett syndrome (RTT) is a neurodevelopmental disorder mainly caused by mutations in the methyl-CpG-binding protein 2 gene (MECP2). MeCP2 is a multifunctional protein involved in many cellular processes, but the mechanisms by which its dysfunction causes disease are not fully understood. The duplication of MECP2 is the cause of a different disorder, MECP2 duplication syndrome (MDS), indicating that its dosage must be tightly regulated for proper cellular function. Moreover, there are patients with a remarkable phenotypic overlap with RTT and mutations in genes other than MECP2 (RTT-like), suggesting they could be involved in similar cellular functions. The purpose of this study was to characterize the molecular alterations in patients with RTT in order to identify potential biomarkers or therapeutic targets for this disorder.
Methods
We used a combination of transcriptomics (RNAseq) and proteomics (TMT-mass spectrometry) to characterize the expression patterns in fibroblast cell lines from 22 patients with RTT and detected mutation in MECP2, 15 patients with MDS, 12 patients with RTT-like phenotypes and 13 healthy controls. Transcriptomics and proteomics data were used to identify differentially expressed genes both at RNA and protein levels, which were further inspected via enrichment and upstream regulator analyses and compared to find shared features in patients with RTT.
Results
We identified molecular alterations in cellular functions and pathways that may contribute to the disease phenotype in patients with RTT,such as deregulated cytoskeletal components, vesicular transport elements, ribosomal subunits and mRNA processsing machinery. We also compared RTT expression profiles with those of MDS seeking changes in opposite directions that could lead to the identification of MeCP2 direct targets. Some of the deregulated transcripts and proteins were consistently affected in patients with RTT-like phenotypes, revealing potentially relevant molecular processes in patients with overlapping traits and different genetic aetiology.
Conclusions
The integration of data in a multi-omic analysis has helped to interpret the molecular consequences of MECP2 dysfunction, contributing to the characterisation of the molecular landscape in patients with RTT. The comparison with MDS provides knowledge of MeCP2 direct targets, whilst the correlation with RTT-like phenotypes highlights processes potentially contributing to the pathomechanism leading these disorders.
The evolution of information donation: a targeted comparison between marmosets and squirrel monkeys
Authors: Sehner Sandro , Willems Erik P. , Baumeyer Adrian , Davis Leyla , Schaik Carel P. van , Burkart Judith M.
Published: January 2023

Proactive information donation is crucial for human cumulative cultural evolution. Evidence for proactive information donation in nonhuman animals is limited to a few examples, and its evolutionary origin remains debated. Here, we examine the role of cooperative breeding for the evolution of proactive information donation by comparing cooperatively breeding common marmosets and an independently breeding sister taxon, the squirrel monkeys, in a series of food sharing experiments. Food sharing was virtually absent in squirrel monkeys but highly prevalent in marmosets. Furthermore, experienced adult marmosets shared more food with immatures when food was more difficult than easy-to-access. This increase was mainly driven by the experienced adults, who proactively initiated sharing more often in the difficult condition, consistent with proactive information donation. These notable species differences have significant implications for the evolution of information donation in cooperatively breeding humans and its absence in other great apes who all breed independently.
Women shopping preference in Bangladesh: Evidence from working and non-working women of Dhaka city
Authors: Imran Sheikh Mohammad , Newaz Nafisa
Published: January 2023

Internet shopping has become a substantial phenomenon in rapidly growing world economy now-a-days. A significant number of entrepreneurs are now involving themselves on several F-commerce platforms (Facebook and commerce). During the era of covid epidemic, women from both working and non-working class intend to visit online sites for shopping to avoid social gathering and ensure proper health and hygiene factors. Moreover, there are notable emergence of supermarkets that offers superior customer services over the traditional marketplace. Nevertheless, in terms of shopping, few customers embrace bargaining while others are focusing on fixed price shop. This paper is aimed to demonstrate the behavioral differences between working and non-working women in case of shopping preference. The research design of this study was descriptive. Purposive sampling method has been used in collecting primary and secondary data. A structured questionnaire using five point Likert scale were used over the 100 respondents in Dhaka city. Statistical package for the social science (SPSS) 25.0 version software was used in data analysis. The result revealed that, working women prefer supermarket and brand shop. On the other hand, online shopping is becoming popular option as a time and energy saving opportunity. Therefore, it is recommended that business planners should focus the potential women customers, know their preference and attract them accordingly which may expand the horizon of business and marketplace.
Implikasi Pengalaman Etnomatematika dan Gender Terhadap Pemahaman Konsep Bilangan Siswa
Authors: Patih Tandri , Halistin Halistin , Saputri Rahma Okta , Azia Azia
Published: January 2023

This research is causal-quantitative research that aims to find out and examine the implications/influence of ethnomathematical experiences, namely things that have been experienced by students related to mathematics who was born based on the culture and value system of an ethnic group; and differences in  characteristics on the understanding of the students’ number concept.  is a trait used as the basis for identifying differences between men and women in terms of socio-cultural conditions, values ​​and behavior, mentality, and so on. The research was carried out in the even semester of the 2020/2021 academic year at SMP Negeri 3 Kendari. The results show that the experience of ethnomathematics has a significant effect on understanding the concept of numbers by 0.302. Meanwhile, differences in  characteristics have no effect on students' understanding of the concept of numbers at SMP Negeri 3 Kendari. This result explains that if students' ethnomathematical experience increases by one unit, then students' knowledge of mathematical concepts will increase by 0.302 units. Ethnomathematics experience can be used to design mathematics learning in an ethnomathematical context based on local wisdom in the classroom. Teachers can consider using ethnomathematical contexts based on students' experiences with traditional games they know and have played to create a condition for learning mathematics that is fun and easier to understand because it is close to students' daily lives and contains cultural values ​​that can shape students' character.
RENDER UNTO CAESAR: THE INTERACTION BETWEEN RELIGION AND ECONOMY IN THE ECONOMIC ACTIVITIES OF CATHOLICS IN THE MEKONG DELTA
Authors:   University of Social Sciences and Humanities, Vietnam National University Ho Chi Minh City, 10-12 Đinh Tiên Hoàng Street, Bến Nghé Ward, District 1, Ho Chi Minh City, Vietnam, Ngô Thị Phương Lan
Published: January 2023

If we look at human nature from the perspective of classical economics, religion and economics do not seem to be directly connected. While religion represents the pursuit of noble values namely truth, beauty, happiness, holiness, and selflessness, doing business is unanimous with the worship of material wealth. However, a closer examination would reveal the interrelations between these two realms. A strong religious belief can actually have significant influence on the way the believers engage in their businesses toward the path of righteousness, and a thriving business could, in turn, enhance the followers’ commitment to the religion. Although the connection between religious belief and economic activities has been discussed in the literature, limited scholarly attention is paid on the phenomenon among the Catholics in Vietnam, a community that has not been examined considerably on areas other than their religious practices or political involvement in the past. Based on an ethnographic study of the Catholics’ economic activities in the Mekong Delta, especially in Cái Mơn Parish in Bến Tre province and the Main Parish in Cần Thơ city, this article argues that religious beliefs could influence and govern the economic behaviour of Catholic followers through the values of honouring God, justice, and charity. These values have inspired the principle of “getting rich righteously” among the Catholics in the Mekong Delta and motivated them to fulfil their civic obligations in society at large. Findings from this study helps shed light on the religious beliefs—economic activities engagement and contribute to the literature on Catholics’ economic activities in Vietnam, an area which remains understudied.
Birth of mining and geology in the Urals
Authors:   Institute of History and Archeology UB RAS, Evgenii Kurlaev
Published: January 2023

Introduction. Since the 17th century, in national historiography there has been hardly any paper devoted to the development of mining technique. This paper considers technnological and organizational aspects related to prospecting and extraction of ore containing gold, silver, copper and iron. Research objective is to analyze the organization of geological prospecting and mining in the Urals in the 17th–early 18th centuries as compared with the technological development of mining and knowledge of local geology. Methods of research. The concept of diffusionism was used to work with concrete historical material. The concept involves the analysis of mining innovations development, borrowing and diffusion. Results. The features have been revealed that characterize the organization of prospecting and mining of ores containing precious metals, copper, and iron. Exploration companies with the participation of foreign specialists were organized to prospect for precious metals, and assay laboratories were used. Originally, copper ore was searched for the presence of gold. In Russia, the craft of mining was borrowed from the Saxons and began with the development of cupriferous sandstone on the river Kama in 1634. The first mine survey and water-driven ore mill are recorded here, and “mining sworn-men” are first mentioned. Depending on the depth and conditions of occurrence, copper ore was extracted by a crew by opencast method from cupriferous sandstones of the Kama region. Ores that contain copper and iron and are typical of the Middle Urals capping, become a serious problem for metallurgy and affected production location. It was the extraction of copper from polymetals that encouraged the organization of the mining by the Saxons, the introduction of a network of mine workings, ore mills, mine dewatering pumps, air supply pumps, and the use of gunpowder for drilling and blasting. Iron ore was extracted by opencast method due to its availability and economic calculations and did not affect the organization of mining
Thickener as an automatic control object
Authors:   Ural State Mining University, Rafail Leonov , Daria Sosnovskaia ,   Ural State Mining University
Published: January 2023

Introduction. Grain motion in the process of pulp sedimentation in a radial thickener was studied to use the typical links of the automatic control system. Research objective is to explore the possibility of describing the sedimentation process by means of typical links of the automatic control theory based on the physics of grain motion in a radial thickener and the equation of grain motion under laminar and turbulent flow conditions. Methods of research. Stokes’ law that determines the drag force resisting a solid sphere when it slowly moves forward in an unbounded viscous fluid (laminar motion) and the Newton– Rittinger law for the turbulent motion of grain formed the basis of the mathematical model, making it possible to develop a program that chooses a particular equation to calculate the grain sedimentation time in accordance with the grain size. The equations helped to obtain the sedimentation time and hence the time taken to reach the thickener’s bottom, which, in their turn, together with the fractional composition, determine the performance of the thickener. Transition curves were thereby obtained for various granulometric composition, percentage of ore in the pulp, thickener height, ore and pulp density. In the future, this made it possible to approximate the process of sediment accumulation by the equations of one or two lag blocks of the automatic control system. Research results. A computer program has been used that describes the process of sediment accumulation in a thickener, considering the granulometric composition as well as pulp and ore grain density. The program showed that the process of sediment accumulation in a thickener can be described with fair accuracy by a first-order lag block for laminar or turbulent grain motion. For a mixture of coarse and fine fractions, ore sedimentation can be approximated by two parallel lag blocks. Conclusions. Sedimentation process approximation by lag blocks, obtained with fair accuracy, can be used when analyzing, designing and adjusting sedimentation automatic control systems.
Improving the pit wall seepage resistance at the V. Grib diamond deposit
Authors:   Belgorod State National Research University, Liudmila A. Elantseva , Sergei V. Fomenko ,   Scientific and technical center NOVOTEK
Published: January 2023

Introduction. V. Grib deposit development includes complex dewatering operations, all water-bearing rocks overlying the mining floor are drained. The open pit is mainly flooded by the Padunsky aquifer system. At present, the open pit is being drained by surface dewatering wells together with mine drainage. In total about 7–8 thousand m3 /h of drainage water is pumped out. Setting of the problem. Uncovering a multilayer water-bearing strata characterized by different filtration characteristics of rocks contributes to the formation of pit walls in the Padunsky strata that have not been dewatered. The height of groundwater seepage on pit walls reaches 50 m due to the low conductivity of the Padunsky strata bottom. It is suggested that the Padunsky strata bottom should be dewatered using lateral drain holes built from the pit to the wall benches in areas with no dewatering wells. Methods of research. For pit wall stability improvement, the developed multilayer numerical model of geofiltration is applied to study the use of lateral drain holes built from the pit. The finite difference method in the GMS MODFLOW package was applied for modelling. Research results. It has been found that the operation of 12 lateral drain holes during 1 year reduces the height of groundwater seepage on pit walls by 15–20 m, contributes to the groundwater level decline of the Padunsky aquifer system by 5–10 m on the drainage contour of dewatering wells; water inflow to lateral drain holes will be 810–850 m3 /h. Conclusions. The feasibility of lateral drain holes for the Padunsky strata dewatering intensification in the adjacent rock mass has been established using the method of numerical modeling.
Analyzing factors impacting the thaw depth of the natural foundation soils under the railway embankment in the Tynda–Kuryan section of BAM
Authors:   AO Cheliabzheldorproekt, Oleg Ishmaev , Olga Guman ,   Ural State Mining University
Published: January 2023

Relevance. The reliability of roadbed on a thawing foundation is a relevant problem both for a new railway line and existing roadbed on permafrost soils. Among other things, design inaccuracies are the reason for deformations of roadbed on icy soils in the conditions of permafrost propagation. That is due to the use of calculation methods that do not take full account of the special nature of thermal and mechanical interaction between the roadbed and the thawing foundation. Research objective is to identify, based on the analyzed material, the relationship between the thaw depth of the natural foundation soils under the railway embankment and its height. Methods of research. An 8 km long section of a Baikal-Amur Mainline on the Kuryan – P.P. 2342 km (Tynda) stretch, with statistical indicators for 61 transverse profiles was taken as an object of research. To check the presence of a linear relationship between the thaw depth of the natural foundation under the roadbed floor and the embankment height, scattering diagrams were constructed and regression equations were found; the relationship nature and strength are determined using the Pearson correlation coefficient. The correlation coefficient reliability is assessed using the Student’s criterion. To assess the quality of the constructed regression model, the statistical significance of the determination coefficient is checked using the Fisher F-criterion. Research results. The calculations allowed to make a conclusion about the statistical significance of the correlation coefficient for the embankments of the two sample groups. The obtained Pearson correlation coefficients are significant, and between the studied features (i.e. the height of the embankment and the thaw depth of the natural foundation under it (in each group)) there is a close inverse relationship, for drainless surfaces the relationship is stronger. Conclusions. The correlation analysis performed in this article shows that the thaw depth of the natural foundation under the railway embankment and the embankment height have a close statistically significant inverse relationship. The analysis prepared according to experimental data gives only a general assessment of the dependence between natural foundation thawing and the embankment height at a local site.