bluuebunny/crossref_metadata_2025 huggingface dataset:
Evidence of Metallic and Polyether Ionophores as Potent Therapeutic Drug Candidate in Cancer Management
Authors: Pandey Pratibha , Khan Fahad , Qari Huda A. , Upadhyay Tarun Kumar , Alkhateeb Abdulhameed F. , Oves Mohammad
Published: July 2022

Cancer remains one of the most crucial human malignancies with a higher mortality rate globally, and is predicted to escalate soon. Dysregulated ion homeostasis in cancerous cells prompted the researchers to investigate further ion homeostasis impeding agents as potent anticancerous agents. Reutilization of FDA-approved non-cancerous drugs has emerged as a practical approach to developing potent, cost-effective drugs for cancer treatment. Across the globe, most nations are incapable of fulfilling the medical demands of cancer patients due to costlier cancerous drugs. Therefore, we have inclined our review towards emphasizing recent advancements in cancer therapies involving ionophores utilization in exploring potent anticancer drugs. Numerous research reports have established the significant anticancerous potential of ionophores in several pre-clinical reports via modulating aberrant cell signaling pathways and enhancing antitumor immunity in immune cells. This review has mainly summarized the most significant ion homeostasis impeding agents, including copper, zinc, calcium, and polyether, that presented remarkable potential in cancer therapeutics via enhanced antitumor immunity and apoptosis induction. Altogether, this study could provide a robust future perspective for developing cost-effective anticancerous drugs rapidly and cost-effectively, thereby combating the limitations of currently available drugs used in cancer treatment.
Literature Mining of Disease Associated Noncoding RNA in the Omics Era
Authors: Fan Jian
Published: July 2022

Noncoding RNAs (ncRNA) are transcripts without protein-coding potential that play fundamental regulatory roles in diverse cellular processes and diseases. The application of deep sequencing experiments in ncRNA research have generated massive omics datasets, which require rapid examination, interpretation and validation based on exiting knowledge resources. Thus, text-mining methods have been increasingly adapted for automatic extraction of relations between an ncRNA and its target or a disease condition from biomedical literature. These bioinformatics tools can also assist in more complex research, such as database curation of candidate ncRNAs and hypothesis generation with respect to pathophysiological mechanisms. In this concise review, we first introduced basic concepts and workflow of literature mining systems. Then, we compared available bioinformatics tools tailored for ncRNA studies, including the tasks, applicability, and limitations. Their powerful utilities and flexibility are demonstrated by examples in a variety of diseases, such as Alzheimer’s disease, atherosclerosis and cancers. Finally, we outlined several challenges from the viewpoints of both system developers and end users. We concluded that the application of text-mining techniques will booster disease-associated ncRNA discoveries in the biomedical literature and enable integrative biology in the current omics era.
Recent Applications of the Multicomponent Synthesis for Bioactive Pyrazole Derivatives
Authors: Becerra Diana , Abonia Rodrigo , Castillo Juan-Carlos
Published: July 2022

Pyrazole and its derivatives are considered a privileged N-heterocycle with immense therapeutic potential. Over the last few decades, the pot, atom, and step economy (PASE) synthesis of pyrazole derivatives by multicomponent reactions (MCRs) has gained increasing popularity in pharmaceutical and medicinal chemistry. The present review summarizes the recent developments of multicomponent reactions for the synthesis of biologically active molecules containing the pyrazole moiety. Particularly, it covers the articles published from 2015 to date related to antibacterial, anticancer, antifungal, antioxidant, α-glucosidase and α-amylase inhibitory, anti-inflammatory, antimycobacterial, antimalarial, and miscellaneous activities of pyrazole derivatives obtained exclusively via an MCR. The reported analytical and activity data, plausible synthetic mechanisms, and molecular docking simulations are organized in concise tables, schemes, and figures to facilitate comparison and underscore the key points of this review. We hope that this review will be helpful in the quest for developing more biologically active molecules and marketed drugs containing the pyrazole moiety.
Novel Phosphonium-Based Ionic Liquid Electrolytes for Battery Applications
Authors: Hofmann Andreas , Rauber Daniel , Wang Tzu-Ming , Hempelmann Rolf , Kay Christopher W. M. , Hanemann Thomas
Published: July 2022

In this study, we address the fundamental question of the physicochemical and electrochemical properties of phosphonium-based ionic liquids containing the counter-ions bis(trifluoromethanesulfonyl)imide ([TFSI]−) and bis(fluorosulfonyl)imide ([FSI]−). To clarify these structure–property as well as structure–activity relationships, trimethyl-based alkyl- and ether-containing phosphonium ILs were systematically synthesized, and their properties, namely density, flow characteristics, alkali metal compatibility, oxidative stability, aluminum corrosivity as well as their use in Li-ion cells were examined comprehensively. The variable moiety on the phosphonium cation exhibited a chain length of four and five, respectively. The properties were discussed as a function of the side chain, counter-ion and salt addition ([Li][TFSI] or [Li][FSI]). High stability coupled with good flow characteristics were found for the phosphonium IL [P1114][TFSI] and the mixture [P1114][TFSI] + [Li][TFSI], respectively.
Bioactive Compounds in Rosehip (Rosa canina) Powder with Encapsulating Agents
Authors: Igual Marta , García-Herrera Patricia , Cámara Rosa M. , Martínez-Monzó Javier , García-Segovia Purificación , Cámara Montaña
Published: July 2022

Rosa canina pseudo-fruits contain interesting bioactive compounds. This work aims to evaluate the use of different biopolymers as encapsulating agents on the content of organic acids, minerals, fibers, phenols, carotenoids, and the antioxidant activity of the powdered product. Fruits were ground and freeze-dried with or without biopolymers (maltodextrin, resistant maltodextrin, cyclodextrin, and pea protein). Rosehip formulated purees with encapsulating agents are an interesting food ingredient rich in fiber and minerals that could be used in the food industry in order to obtain different functional foods. Results obtained in this study show that all formulated samples are a good source of potassium, calcium, magnesium, and manganese. Both rosehip without biopolymers and rosehip with pea protein formulations are also a good source of Zn. Formulation with pea protein can be claimed as a good source of Fe. All formulations are food ingredients with a very high content of ascorbic acid. Comparing the encapsulating agents, depending on the studied bioactive compound samples behaved differently. In conclusion, it can be indicated that pea protein is recommended as an encapsulating agent since the rosehip with pea protein sample has the highest content of fiber, minerals, organic acids, and carotenoids among the encapsulating agents studied.
The Synthesis of Manganese Hydroxide Nanowire Arrays for a High-Performance Zinc-Ion Battery
Authors: Gong Jiangfeng , Zhu Bingxin , Zhang Zhupeng , Xiang Yuanyuan , Tang Chunmei , Ding Qingping , Wu Xiang
Published: July 2022

The morphology, microstructure as well as the orientation of cathodic materials are the key issues when preparing high-performance aqueous zinc-ion batteries (ZIBs). In this paper, binder-free electrode Mn(OH)2 nanowire arrays were facilely synthesized via electrodeposition. The nanowires were aligned vertically on a carbon cloth. The as-prepared Mn(OH)2 nanowire arrays were used as cathode to fabricate rechargeable ZIBs. The vertically aligned configuration is beneficial to electron transport and the free space between the nanowires can provide more ion-diffusion pathways. As a result, Mn(OH)2 nanowire arrays yield a high specific capacitance of 146.3 Ma h g−1 at a current density of 0.5 A g−1. They also demonstrates ultra-high diffusion coefficients of 4.5 × 10−8~1.0 × 10−9 cm2 s−1 during charging and 1.0 × 10−9~2.7 × 10−11 cm−2 s−1 during discharging processes, which are one or two orders of magnitude higher than what is reported in the studies. Furthermore, the rechargeable Zn//Mn(OH)2 battery presents a good capacity retention of 61.1% of the initial value after 400 cycles. This study opens a new avenue to boost the electrochemical kinetics for high-performance aqueous ZIBs.
The Transformation of 0-D Carbon Dots into 1-, 2- and 3-D Carbon Allotropes: A Minireview
Authors: Mokoloko Lerato L. , Forbes Roy P. , Coville Neil J.
Published: July 2022

Carbon dots (CDs) represent a relatively new type of carbon allotrope with a 0-D structure and with nanoparticle sizes < 10 nm. A large number of research articles have been published on the synthesis, characteristics, mechanisms and applications of this carbon allotrope. Many of these articles have also shown that CDs can be synthesized from “bottom-up” and “top-down” methods. The “top-down” methods are dominated by the breaking down of large carbon structures such as fullerene, graphene, carbon black and carbon nanotubes into the CDs. What is less known is that CDs also have the potential to be used as carbon substrates for the synthesis of larger carbon structures such as 1-D carbon nanotubes, 2-D or 3-D graphene-based nanosheets and 3-D porous carbon frameworks. Herein, we present a review of the synthesis strategies used to convert the 0-D carbons into these higher-dimensional carbons. The methods involve the use of catalysts or thermal procedures to generate the larger structures. The surface functional groups on the CDs, typically containing nitrogen and oxygen, appear to be important in the process of creating the larger carbon structures that typically are formed via the generation of covalent bonds. The CD building blocks can also ‘aggregate’ to form so called supra-CDs. The mechanism for the formation of the structures made from CDs, the physical properties of the CDs and their applications (for example in energy devices and as reagents for use in medicinal fields) will also be discussed. We hope that this review will serve to provide valuable insights into this area of CD research and a novel viewpoint on the exploration of CDs.
Ferroelectricity and Piezoelectricity in 2D Van der Waals CuInP2S6 Ferroelectric Tunnel Junctions
Authors: Jia Tingting , Chen Yanrong , Cai Yali , Dai Wenbin , Zhang Chong , Yu Liang , Yue Wenfeng , Kimura Hideo , Yao Yingbang , Yu Shuhui , Guo Quansheng , Cheng Zhenxiang
Published: July 2022

CuInP2S6 (CIPS) is a novel two-dimensional (2D) van der Waals (vdW) ferroelectric layered material with a Curie temperature of TC~315 K, making it promising for great potential applications in electronic and photoelectric devices. Herein, the ferroelectric and electric properties of CIPS at different thicknesses are carefully evaluated by scanning probe microscopy techniques. Some defects in some local regions due to Cu deficiency lead to a CuInP2S6–In4/3P2S6 (CIPS–IPS) paraelectric phase coexisting with the CIPS ferroelectric phase. An electrochemical strain microscopy (ESM) study reveals that the relaxation times corresponding to the Cu ions and the IPS ionospheres are not the same, with a significant difference in their response to DC voltage, related to the rectification effect of the ferroelectric tunnel junction (FTJ). The electric properties of the FTJ indicate Cu+ ion migration and propose that the current flow and device performance are dynamically controlled by an interfacial Schottky barrier. The addition of the ferroelectricity of CIPS opens up applications in memories and sensors, actuators, and even spin-orbit devices based on 2D vdW heterostructures.
Feasible Structure Manipulation of Vanadium Selenide into VSe2 on Au(111)
Authors: Huang Chaoqin , Xie Lei , Zhang Huan , Wang Hongbing , Hu Jinping , Liang Zhaofeng , Jiang Zheng , Song Fei
Published: July 2022

Vanadium diselenide (VSe2), a member of the transition metal dichalcogenides (TMDs), is proposed with intriguing properties. However, a comprehensive investigation of VSe2 (especially regarding on the growth mechanism) is still lacking. Herein, with the molecular beam epitaxy (MBE) measures frequently utilized in surface science, we have successfully synthesized the single-layer VSe2 on Au(111) and revealed its structural transformation using a combination of scanning tunneling microscopy (STM) and density functional theory (DFT). Initially, formation of the honeycomb structure is observed with the moiré periodicity, which is assigned to VSe2. Followed by stepwise annealing, defective structures with streaked patterns start to emerge due to the depletion of Se, which can be reversed to the pristine VSe2 by resupplying Se. With more V than Se deposited, a new compound that has no bulk analogue is discovered on Au(111), which could be transformed back to VSe2 after providing excessive Se. As the realization of manipulating V selenide phases is subtly determined by the relative ratio of V to Se and post-annealing treatments, this report provides useful insights toward fundamental understanding of the growth mechanism of TMDs and might promote the wide application of VSe2 in related fields such as catalysis and nanoelectronics.
A Numerical Investigation of a Melting Rate Enhancement inside a Thermal Energy Storage System of Finned Heat Pipe with Nano-Enhanced Phase Change Material
Authors: Jirawattanapanit Anuwat , Abderrahmane Aissa , Mourad Abe , Guedri Kamel , Younis Obai , Bouallegue Belgacem , Subkrajang Khanyaluck , Rajchakit Grienggrai , Shah Nehad Ali
Published: July 2022

Thermal energy storage via the use of latent heat and phase transition materials is a popular technology in energy storage systems. It is vital to research different thermal enhancement techniques to further improve phase transition materials’ weak thermal conductivity in these systems. This work addresses the creation of a basic shell and a tube thermal storage device with wavy outer walls. Then, two key methods for thermal augmentation are discussed: fins and the use of a nano-enhanced phase change material (NePCM). Using the enthalpy–porosity methodology, a numerical model is developed to highlight the viability of designing such a model utilizing reduced assumptions, both for engineering considerations and real-time predictive control methods. Different concentrations of copper nanoparticles (0, 2, and 4 vol%) and wavenumbers (4,6 and 8) are investigated in order to obtain the best heat transmission and acceleration of the melting process. The time required to reach total melting in the studied TES system is reduced by 14% and 31% in the examined TES system, respectively, when NePCM (4 vol% nanoparticles) and N = 8 are used instead of pure PCM and N = 4. The finding from this investigation could be used to design a shell-and-tube base thermal energy storage unit.
Low-Dimensional Nanomaterial Systems Formed by IVA Group Elements Allow Energy Conversion Materials to Flourish
Authors: Li Dan , Lv Jinsheng , Shi Mengfan , Wang Liru , Yang Tian , Yang Ya’nan , Chen Nan
Published: July 2022

In response to the exhaustion of traditional energy, green and efficient energy conversion has attracted growing attention. The IVA group elements, especially carbon, are widely distributed and stable in the earth’s crust, and have received a lot of attention from scientists. The low-dimensional structures composed of IVA group elements have special energy band structure and electrical properties, which allow them to show more excellent performance in the fields of energy conversion. In recent years, the diversification of synthesis and optimization of properties of IVA group elements low-dimensional nanomaterials (IVA-LD) contributed to the flourishing development of related fields. This paper reviews the properties and synthesis methods of IVA-LD for energy conversion devices, as well as their current applications in major fields such as ion battery, moisture electricity generation, and solar-driven evaporation. Finally, the prospects and challenges faced by the IVA-LD in the field of energy conversion are discussed.
Controlled Oxidation of Cobalt Nanoparticles to Obtain Co/CoO/Co3O4 Composites with Different Co Content
Authors: Lozhkomoev Aleksandr S. , Pervikov Alexander V. , Kazantsev Sergey O. , Suliz Konstantin V. , Veselovskiy Roman V. , Miller Andrey A. , Lerner Marat I.
Published: July 2022

The paper studies patterns of interaction of electroexplosive Co nanoparticles with air oxygen during heating. The characteristics of Co nanoparticles and composite Co/CoO/Co3O4 nanoparticles formed as a result of oxidation were studied using transmission electron microscopy, X-ray phase analysis, thermogravimetric analysis, differential scanning calorimetry, and vibrating sample magnetometry. It was established that nanoparticles with similar morphology in the form of hollow spheres with different content of Co, CoO, and Co3O4 can be produced by varying oxidation temperatures. The influence of the composition of composite nanoparticles on their magnetic characteristics is shown.
Boosting the Oxygen Evolution Reaction by Controllably Constructing FeNi3/C Nanorods
Authors: Yu Xu , Pan Zhiqiang , Zhao Zhixin , Zhou Yuke , Pei Chengang , Ma Yifei , Park Ho Seok , Wang Mei
Published: July 2022

Transition bimetallic alloy-based catalysts are regarded as attractive alternatives for the oxygen evolution reaction (OER), attributed to their competitive economics, high conductivity and intrinsic properties. Herein, we prepared FeNi3/C nanorods with largely improved catalytic OER activity by combining hydrothermal reaction and thermal annealing treatment. The temperature effect on the crystal structure and chemical composition of the FeNi3/C nanorods was revealed, and the enhanced catalytic performance of FeNi3/C with an annealing temperature of 400 °C was confirmed by several electrochemical tests. The outstanding catalytic performance was assigned to the formation of bimetallic alloys/carbon composites. The FeNi3/C nanorods showed an overpotential of 250 mV to afford a current density of 10 mA cm−2 and a Tafel slope of 84.9 mV dec−1, which were both smaller than the other control samples and commercial IrO2 catalysts. The fast kinetics and high catalytic stability were also verified by electrochemical impendence spectroscopy and chronoamperometry for 15 h. This study is favorable for the design and construction of bimetallic alloy-based materials as efficient catalysts for the OER.
A Review of the Advances and Challenges in Measuring the Thermal Conductivity of Nanofluids
Authors: Souza Reinaldo R. , Faustino Vera , Gonçalves Inês M. , Moita Ana S. , Bañobre-López Manuel , Lima Rui
Published: July 2022

Fluids containing colloidal suspensions of nanometer-sized particles (nanofluids) have been extensively investigated in recent decades with promising results. Driven by the increase in the thermal conductivity of these new thermofluids, this topic has been growing in order to improve the thermal capacity of a series of applications in the thermal area. However, when it comes to measure nanofluids (NFs) thermal conductivity, experimental results need to be carefully analyzed. Hence, in this review work, the main traditional and new techniques used to measure thermal conductivity of the NFs are presented and analyzed. Moreover, the fundamental parameters that affect the measurements of the NFs’ thermal conductivity, such as, temperature, concentration, preparation of NFs, characteristics and thermophysical properties of nanoparticles, are also discussed. In this review, the experimental methods are compared with the theoretical methods and, also, a comparison between experimental methods are made. Finally, it is expected that this review will provide a guidance to researchers interested in implementing and developing the most appropriate experimental protocol, with the aim of increasing the level of reliability of the equipment used to measure the NFs thermal conductivity.
A Study on the Photoelectric Properties of Dual Ridge Terahertz Quantum Cascade Lasers at 3.1 THz
Authors: Yang Qi , Zhang Jicheng , Wang Xuemin , Zhan Zhiqiang , Jiang Tao , Li Jia , Zou Ruijiao , Li Keyu , Chen Fengwei , Wu Weidong
Published: July 2022

High-power, incoherent THz array sources are widely desired in some applications due to their low energy, unique terahertz fingerprint, and image. In this work, a dual ridge terahertz quantum cascade laser lasing at 3.1 THz is presented, and the device’s performance is analyzed in detail. The maximum output power can reach 512 mW when the two ridges work simultaneously in continuous-wave mode, with a threshold current density of 281 A/cm2 at 15 K. While the peak power is approximately 704 mW in pulse-wave mode at 15 K, the lasing still could be observed approximately 7 mW at 125 K. The far-field pattern of the dual ridge THz QCL is detected by a THz camera; two light spots typically show a single-lobe Gaussian distribution. The experimental results provide a reference for realizing high-power THz quantum cascade lasers, and they will provide some guidance for the structural design of multiple ridges or laser arrays.
Synthesis and Electrochemical Performance of the Orthorhombic V2O5·nH2O Nanorods as Cathodes for Aqueous Zinc Batteries
Authors: Tan Xiaoping , Guo Gaoli , Wang Kaidi , Zhang Huang
Published: July 2022

Aqueous zinc-ion batteries offer the greatest promise as an alternative technology for low-cost and high-safety energy storage. However, the development of high-performance cathode materials and their compatibility with aqueous electrolytes are major obstacles to their practical applications. Herein, we report the synthesis of orthorhombic V2O5·nH2O nanorods as cathodes for aqueous zinc batteries. As a result, the electrode delivers a reversible capacity as high as 320 mAh g−1 at 1.0 A g−1 and long-term cycling stability in a wide window of 0.2 to 1.8 V using a mild ZnSO4 aqueous electrolyte. The superior performance can be attributed to the improved stability of materials, inhibited electrolyte decomposition and facilitated charge transfer kinetics of such materials for aqueous zinc storage. Furthermore, a full cell using microsized Zn powder as an anode within capacity-balancing design exhibits high capacity and stable cycling performance, proving the feasibility of these materials for practical application.
Synergetic Effect of Polyaniline and Graphene in Their Composite Supercapacitor Electrodes: Impact of Components and Parameters of Chemical Oxidative Polymerization
Authors: Okhay Olena , Tkach Alexander
Published: July 2022

The current development of clean and high efficiency energy sources such as solar or wind energy sources has to be supported by the design and fabrication of energy storage systems. Electrochemical capacitors (or supercapacitors (SCs)) are promising devices for energy storage thanks to their highly efficient power management and possible small size. However, in comparison to commercial batteries, SCs do not have very high energy densities that significantly limit their applications. The value of energy density directly depends on the capacitance of full SCs and their cell voltage. Thus, an increase of SCs electrode specific capacitance together with the use of the wide potential window electrolyte can result in high performance SCs. Conductive polymer polyaniline (PANI) as well as carbonaceous materials graphene (G) or reduced graphene oxide (RGO) have been widely studied for usage in electrodes of SCs. Although pristine PANI electrodes have shown low cycling stability and graphene sheets can have low specific capacitance due to agglomeration during their preparation without a spacer, their synergetic effect can lead to high electrochemical properties of G/PANI composites. This review points out the best results for G/PANI composite in comparison to that of pristine PANI or graphene (or RGO). Various factors, such as the ratio between graphene and PANI, oxidants, time, and the temperature of chemical oxidative polymerization, which have been determined to influence the morphology, capacitance, cycling stability, etc. of the composite electrode materials measured in three-electrode system are discussed. Consequently, we provide an in-depth summary on diverse promising approaches of significant breakthroughs in recent years and provide strategies to choose suitable electrodes based on PANI and graphene.
Theoretical Study of LED Operating in Noncarrier Injection Mode
Authors: Wu Chaoxing , Wang Kun , Guo Tailiang
Published: July 2022

Non-carrier injection (NCI) mode is an emerging driving mode for light-emitting diodes (LEDs) with numerous advantages. Revealing the relationship between the current and the applied alternating voltage in mathematical formulas is of great significance for understanding the working mechanism of NCI–LEDs and improving device performance. In this work, a theoretical model of the relationship between NCI–LED current and time-varying voltage is constructed. Based on the theoretical model, the real-time current is derived, which is consistent with the experimental results. Key parameters that can improve device performance are discussed, including voltage amplitude, frequency, equivalent capacitance, and LED reverse current. The theory presented here can serve as an important guidance for the rational design of the NCI–LEDs.
On Capacitance and Energy Storage of Supercapacitor with Dielectric Constant Discontinuity
Authors: Zhou Shiqi
Published: July 2022

The classical density functional theory (CDFT) is applied to investigate influences of electrode dielectric constant on specific differential capacitance Cd and specific energy storage E of a cylindrical electrode pore electrical double layer. Throughout all calculations the electrode dielectric constant varies from 5, corresponding to a dielectric electrode, to εwr= 108 corresponding to a metal electrode. Main findings are summarized as below. (i): By using a far smaller value of the solution relative dielectric constant εr=10, which matches with the reality of extremely narrow tube, one discloses that a rather high saturation voltage is needed to attain the saturation energy storage in the ultra-small pore. (ii): Use of a realistic low εr=10 value brings two obvious effects. First, influence of bulk electrolyte concentration on the Cd is rather small except when the electrode potential is around the zero charge potential; influence on the E curve is almost unobservable. Second, there remain the Cd and E enhancing effects caused by counter-ion valency rise, but strength of the effects reduces greatly with dropping of the εr value; in contrast, the Cd and E reducing effects coming from the counter-ion size enhancing remain significant enough for the low εr value. (iii) A large value of electrode relative dielectric constant εrw always reduces both the capacitance and energy storage; moreover, the effect of the εrw value gets eventually unobservable for small enough pore when the εrw value is beyond the scope corresponding to dielectric electrode. It is analyzed that the above effects take their rise in the repulsion and attraction on the counter-ions and co-ions caused by the electrode bound charges and a strengthened inter-counter-ion electrostatic repulsion originated in the low εr value.
Microwave Plasma-Enhanced Parylene–Metal Multilayer Design from Metal Salts
Authors: Weber Mirco , Vorobev David , Viöl Wolfgang
Published: July 2022

In this paper, a new approach for the synthesis of Parylene–metal multilayers was examined. The metal layers were derived from a metal salt solution in methanol and a post-drying plasma reduction treatment. This process was designed as a one-pot synthesis, which needs a very low amount of resources and energy compared with those using electron beam sputtering processes. The Parylene coatings were obtained after reduction plasma treatments with Parylene C. Therefore, a Parylene coating device with an included plasma microwave generator was used to ensure the character of a one-pot synthesis. This process provided ultra-thin metal salt layers in the range of 1–2 nm for layer thickness and 10–30 nm for larger metal salt agglomerates all over the metal salt layer. The Parylene layers were obtained with thicknesses between approx. 4.5 and 4.7 µm from ellipsometric measurements and 5.7–6.3 µm measured by white light reflectometry. Tensile strength analysis showed an orthogonal pulling stress resistance of around 4500 N. A surface roughness of 4–8 nm for the metal layers, as well as 20–29 nm for the Parylene outer layer, were measured. The wettability for non-polar liquids with a contact angle of 30° was better than for polar liquids, such as water, achieving 87° on the Parylene C surfaces.
3.96 kW All-Fiberized Linearly Polarized and Narrow Linewidth Fiber Laser with Near-Diffraction-Limited Beam Quality
Authors: Ren Shuai , Ma Pengfei , Li Wei , Wang Guangjian , Chen Yisha , Song Jiaxin , Liu Wei , Zhou Pu
Published: July 2022

In this paper, we realize a 3.96 kW all-fiberized and polarization-maintained (PM) amplifier with narrow linewidth and near-diffraction-limited beam quality. Based on a master oscillator power amplifier (MOPA) configuration seeded with phase-modulated single-frequency laser, a 3.96 kW signal laser is achieved with a 3 dB linewidth of 0.62 nm at the pump power of 5.02 kW. At the maximum output power, the polarization extinction ratio (PER) is ~13.9 dB, and the beam quality (M2 factor) is M2x = 1.31, M2y = 1.41. As far as we know, this is the maximum output power of PM narrow linewidth fiber laser with near-diffraction-limited beam quality and all-fiber format.
Silver Nanoparticles Densely Grafted with Nitroxides as a Recyclable Green Catalyst in the Selective Oxidation of Alcohols
Authors: Krogul-Sobczak Agnieszka , Pisarek Natalia , Cieciórski Piotr , Megiel Elżbieta
Published: July 2022

The selective oxidation of alcohols, leading to appropriate aldehydes, is widely recognised as one of the most important reactions in organic synthesis. With ever-increasing environmental concerns, much attention has been directed toward developing catalytic protocols that use molecular oxygen as an oxidant. An ideal green oxidation process should employ a highly active, selective and recyclable catalyst that can work with oxygen under mild conditions. This paper presents a successful application of densely grafted silver nanostructures with stable nitroxide radicals (N-AgNPs) as an effective, easily-recovered and regenerable catalyst for the selective oxidation of alcohols. The fabricated ultra-small and narrow dispersive silver nanoparticles have been fully characterised using physicochemical methods (TEM, DLS, XPS, TGA). N-AgNPs have been successfully applied to oxidise several model alcohols: benzyl alcohol, 4-pyridinemethanol, furfuryl alcohol, 1-phenyl ethanol, n-heptanol and allyl alcohol under mild conditions using oxygen as a stoichiometric oxidant. Notably, the fabricated nitroxide grafted silver nanoparticles (N-AgNPs) were reused more than ten times in the oxidation of a series of primary alcohols to corresponding aldehydes under mild conditions with very high yields and a selectivity close to 100%.
Dissipative Phase Transition in Systems with Two-Photon Drive and Nonlinear Dissipation near the Critical Point
Authors: Mylnikov Valentin Yu. , Potashin Sergey O. , Sokolovskii Grigorii S. , Averkiev Nikita S.
Published: July 2022

In this paper, we examine dissipative phase transition (DPT) near the critical point for a system with two-photon driving and nonlinear dissipations. The proposed mean-field theory, which explicitly takes into account quantum fluctuations, allowed us to describe properly the evolutionary dynamics of the system and to demonstrate new effects in its steady-state. We show that the presence of quantum fluctuations leads to a power-law dependence of the anomalous average at the phase transition point, with which the critical exponent is associated. Also, we investigate the effect of the quantum fluctuations on the critical point renormalization and demonstrate the existence of a two-photon pump “threshold”. It is noteworthy that the obtained results are in a good agreement with the numerical simulations.
NIR-Absorbing Mesoporous Silica-Coated Copper Sulphide Nanostructures for Light-to-Thermal Energy Conversion
Authors: Fanizza Elisabetta , Mastrogiacomo Rita , Pugliese Orietta , Guglielmelli Alexa , De Sio Luciano , Castaldo Rachele , Scavo Maria , Giancaspro Mariangela , Rizzi Federica , Gentile Gennaro , Vischio Fabio , Carrieri Livianna , De Pasquale Ilaria , Mandriota Giacomo , Petronella Francesca , Ingrosso Chiara , Lavorgna Marino , Comparelli Roberto , Striccoli Marinella , Curri Maria , Depalo Nicoletta
Published: July 2022

Plasmonic nanostructures, featuring near infrared (NIR)-absorption, are rising as efficient nanosystems for in vitro photothermal (PT) studies and in vivo PT treatment of cancer diseases. Among the different materials, new plasmonic nanostructures based on Cu2−xS nanocrystals (NCs) are emerging as valuable alternatives to Au nanorods, nanostars and nanoshells, largely exploited as NIR absorbing nanoheaters. Even though Cu2−xS plasmonic properties are not linked to geometry, the role played by their size, shape and surface chemistry is expected to be fundamental for an efficient PT process. Here, Cu2−xS NCs coated with a hydrophilic mesoporous silica shell (MSS) are synthesized by solution-phase strategies, tuning the core geometry, MSS thickness and texture. Besides their loading capability, the silica shell has been widely reported to provide a more robust plasmonic core protection than organic molecular/polymeric coatings, and improved heat flow from the NC to the environment due to a reduced interfacial thermal resistance and direct electron–phonon coupling through the interface. Systematic structural and morphological analysis of the core-shell nanoparticles and an in-depth thermoplasmonic characterization by using a pump beam 808 nm laser, are carried out. The results suggest that large triangular nanoplates (NPLs) coated by a few tens of nanometers thick MSS, show good photostability under laser light irradiation and provide a temperature increase above 38 °C and a 20% PT efficiency upon short irradiation time (60 s) at 6 W/cm2 power density.
Interfacial Bonding Improvement through Nickel Decoration on Carbon Nanotubes in Carbon Nanotubes/Cu Composite Foams Reinforced Copper Matrix Composites
Authors: Wang Dan , Yan An , Liu Yichun , Wu Zhong , Gan Xueping , Li Fengxian , Tao Jingmei , Li Caiju , Yi Jianhong
Published: July 2022

Inhomogeneous structures with carbon nanotubes (CNTs), reinforced with Cu composite foams as the reinforcing skeletons (CNTs/Cuf®Cu), have been designed to overcome the paradox between strength and ductility or conductivity in copper matrix composites. The interface between CNTs and the copper matrix is usually weak, due to poor wettability and interaction. In this study, nickel nanoparticles are decorated onto CNTs to improve interfacial bonding. The broader interface transition area between CNTs and copper with Ni3C interfacial products formed, and a combination of improved electrical conductivity (95.6% IACS), tensile strength (364.9 MPa), and elongation (40.6%) was achieved for the Ni-decorated CNTs/Cuf®Cu (Ni-CNTs/Cuf®Cu). In addition, the strengthening mechanisms are discussed in this study.
Recent Progress of Nanogenerators for Green Energy Harvesting: Performance, Applications, and Challenges
Authors: Delgado-Alvarado Enrique , Elvira-Hernández Ernesto A. , Hernández-Hernández José , Huerta-Chua Jesús , Vázquez-Leal Héctor , Martínez-Castillo Jaime , García-Ramírez Pedro J. , Herrera-May Agustín L.
Published: July 2022

Natural sources of green energy include sunshine, water, biomass, geothermal heat, and wind. These energies are alternate forms of electrical energy that do not rely on fossil fuels. Green energy is environmentally benign, as it avoids the generation of greenhouse gases and pollutants. Various systems and equipment have been utilized to gather natural energy. However, most technologies need a huge amount of infrastructure and expensive equipment in order to power electronic gadgets, smart sensors, and wearable devices. Nanogenerators have recently emerged as an alternative technique for collecting energy from both natural and artificial sources, with significant benefits such as light weight, low-cost production, simple operation, easy signal processing, and low-cost materials. These nanogenerators might power electronic components and wearable devices used in a variety of applications such as telecommunications, the medical sector, the military and automotive industries, and internet of things (IoT) devices. We describe new research on the performance of nanogenerators employing several green energy acquisition processes such as piezoelectric, electromagnetic, thermoelectric, and triboelectric. Furthermore, the materials, applications, challenges, and future prospects of several nanogenerators are discussed.
Antifungal Activity of Select Essential Oils against Candida auris and Their Interactions with Antifungal Drugs
Authors: Parker Ryan A. , Gabriel Kyle T. , Graham Kayla D. , Butts Bethany K. , Cornelison Christopher T.
Published: July 2022

Candida auris is an emerging fungal pathogen that commonly causes nosocomial blood infections in the immunocompromised. Several factors make this pathogen a global threat, including its misidentification as closely related species, its ability to survive for weeks on fomites, and its resistance to commonly prescribed antifungal drugs, sometimes to all three classes of systemic antifungal drugs. These factors demonstrate a need for the development of novel therapeutic approaches to combat this pathogen. In the present study, the antifungal activities of 21 essential oils were tested against C. auris. Several essential oils were observed to inhibit the growth and kill C. auris, Candida lusitaniae, and Saccharomyces cerevisiae when in direct contact and at concentrations considered safe for topical use. The most effective essential oils were those extracted from lemongrass, clove bud, and cinnamon bark. These essential oils also elicited antifungal activity in gaseous form. The efficacies of formulations comprised of these three essential oils in combination with fluconazole, amphotericin B, flucytosine, and micafungin were explored. While synergism was neither observed with cinnamon bark oil nor any of the antifungal drugs, lemongrass oil displayed synergistic, additive, and indifferent interactions with select drugs. Formulations of clove bud oil with amphotericin B resulted in antagonistic interactions but displayed synergistic interactions with fluconazole and flucytosine. These essential oils and their combinations with antifungal drugs may provide useful options for surface disinfection, skin sanitization, and possibly even the treatment of Candida infections.
Bendiocarb and Malathion Resistance in Two Major Malaria Vector Populations in Cameroon Is Associated with High Frequency of the G119S Mutation (Ace-1) and Overexpression of Detoxification Genes
Authors: Ngangue-Siewe Idriss Nasser , Ndjeunia-Mbiakop Paulette , Kala-Chouakeu Nelly Armanda , Bamou Roland , Talipouo Abdou , Djamouko-Djonkam Landre , Vontas John , Mavridis Konstantinos , Tombi Jeannette , Tchuinkam Timoléon , Mbida-Mbida Jean Arthur , Antonio-Nkondjio Christophe
Published: July 2022

The spread of pyrethroid resistance in malaria vectors is a major threat affecting the performance of current control measures. However, there is still not enough information on the resistance profile of mosquitoes to carbamates and organophosphates which could be used as alternatives. The present study assessed the resistance profile of Anopheles gambiae s.l. to bendiocarb and malathion, at the phenotypic and molecular levels, in different eco-epidemiological settings in Cameroon. Anopheles gambiae s.l. mosquitoes were collected from four eco-epidemiological settings across the country and their susceptibility level to bendiocarb and malathion was determined using WHO tubes bioassays. The ace-1 target site G119S mutation was screened by PCR. Reverse Transcription quantitative PCR 3-plex TaqMan assays were used to quantify the level of expression of eight genes associated with metabolic resistance. Resistance to malathion and/or bendiocarb was recorded in all study sites except in mosquitoes collected in Kaélé and Njombé. The Ace-1 (G119S) mutation was detected in high frequencies (>40%) in Kékem and Santchou. Both An. gambiae and An. coluzzii were detected carrying this mutation. The cytochrome P450s gene Cyp6p3 associated with carbamate resistance and the glutathione S-transferase gene Gste2 associated with organophosphate resistance were found to be overexpressed. Genes associated with pyrethroid (Cyp6m2, Cyp9k1, Cyp6p3) and organochlorine (Gste2, Cyp6z1, Cyp6m2) and cuticle resistance (Cyp4g16) were also overexpressed. The rapid spread of resistance to organophosphates and carbamates could seriously compromise future control strategies based on IRS. It is therefore becoming important to assess the magnitude of bendiocarb and malathion resistance countrywide.
New Reports of Phytophthora Species in Plant Nurseries in Spain
Authors: Mora-Sala Beatriz , León Maela , Pérez-Sierra Ana , Abad-Campos Paloma
Published: July 2022

The plant nursery industry has become an ideal reservoir for Phytophthora species and other soilborne pathogens. In this context, isolation from tissues and soil of ornamental and forest plants from nurseries in four regions of Spain was carried out. A high diversity of Phytophthora species was confirmed. Fourteen Phytophthora phylotypes (P. cactorum, P. cambivora, P. cinnamomi, P. citrophthora, P. crassamura, P. gonapodyides, P. hedraiandra, P. nicotianae, P. niederhauserii, P. palmivora, P. plurivora, P. pseudocryptogea, P. sansomeana, and Phytophthora sp. tropicalis-like 2) were isolated from over 500 plant samples of 22 species in 19 plant genera. Nine species were detected in water sources, two of them (P. bilorbang and P. lacustris) exclusively from water samples. P. crassamura was detected for the first time in Spain. This is the first time P. pseudocryptogea is isolated from Chamaecyparis lawsoniana and Yucca rostrata in Spain.
Royal Jelly Components Encapsulation in a Controlled Release System—Skin Functionality, and Biochemical Activity for Skin Applications
Authors: Spanidi Eleni , Athanasopoulou Sophia , Liakopoulou Angeliki , Chaidou Angeliki , Hatziantoniou Sophia , Gardikis Konstantinos
Published: July 2022

Royal jelly is a yellowish-white substance with a gel texture that is secreted from the hypopharyngeal and mandibular glands of young worker bees. It consists mainly of water (50–56%), proteins (18%), carbohydrates (15%), lipids (3–6%), minerals (1.5%), and vitamins, and has many beneficial properties such as antimicrobial, anti-inflammatory, anticancer, antioxidant, antidiabetic, immunomodulatory, and anti-aging. Royal jelly has been used since ancient times in traditional medicine, cosmetics and as a functional food due to its high nutritional value. The main bioactive substances are royalactin, and 10-hydroxy-2-decenoic acid (10-HDA). Other important bioactive molecules with antioxidant and photoprotective skin activity are polyphenols. However, they present difficulties in extraction and in use as they are unstable physicochemically, and a higher temperature causes color change and component degradation. In the present study, a new encapsulation and delivery system consisting of liposomes and cyclodextrins incorporating royal jelly has been developed. The new delivery system aims to the elimination of the stability disadvantages of royal jelly’s sensitive component 10-HDA, but also to the controlled release of its ingredients and, more particularly, 10-HDA, for an enhanced bioactivity in cosmeceutical applications.
Fine Control of In Vivo Magnetic Hyperthermia Using Iron Oxide Nanoparticles with Different Coatings and Degree of Aggregation
Authors: Luengo Yurena , Díaz-Riascos Zamira V. , García-Soriano David , Teran Francisco J. , Artés-Ibáñez Emilio J. , Ibarrola Oihane , Somoza Álvaro , Miranda Rodolfo , Schwartz Simó , Abasolo Ibane , Salas Gorka
Published: July 2022

The clinical implementation of magnetic hyperthermia has experienced little progress since the first clinical trial was completed in 2005. Some of the hurdles to overcome are the reliable production of magnetic nanoparticles with controlled properties and the control of the temperature at the target tissue in vivo. Here, forty samples of iron oxide superparamagnetic nanoparticles were prepared by similar methods and thoroughly characterized in terms of size, aggregation degree, and heating response. Selected samples were intratumorally administered in animals with subcutaneous xenografts of human pancreatic cancer. In vivo experiments showed that it is possible to control the rise in temperature by modulating the field intensity during in vivo magnetic hyperthermia protocols. The procedure does not require sophisticated materials and it can be easily implemented by researchers or practitioners working in magnetic hyperthermia therapies.
Proof-of-Concept Organ-on-Chip Study: Topical Cinnamaldehyde Exposure of Reconstructed Human Skin with Integrated Neopapillae Cultured under Dynamic Flow
Authors: Vahav Irit , Thon Maria , van den Broek Lenie J. , Spiekstra Sander W. , Atac Beren , Lindner Gerd , Schimek Katharina , Marx Uwe , Gibbs Susan
Published: July 2022

Pharmaceutical and personal care industries require human representative models for testing to ensure the safety of their products. A major route of penetration into our body after substance exposure is via the skin. Our aim was to generate robust culture conditions for a next generation human skin-on-chip model containing neopapillae and to establish proof-of-concept testing with the sensitizer, cinnamaldehyde. Reconstructed human skin consisting of a stratified and differentiated epidermis on a fibroblast populated hydrogel containing neopapillae spheroids (RhS-NP), were cultured air-exposed and under dynamic flow for 10 days. The robustness of three independent experiments, each with up to 21 intra-experiment replicates, was investigated. The epidermis was seen to invaginate into the hydrogel towards the neopapille spheroids. Daily measurements of lactate dehydrogenase (LDH) and glucose levels within the culture medium demonstrated high viability and stable metabolic activity throughout the culture period in all three independent experiments and in the replicates within an experiment. Topical cinnamaldehyde exposure to RhS-NP resulted in dose-dependent cytotoxicity (increased LDH release) and elevated cytokine secretion of contact sensitizer specific IL-18, pro-inflammatory IL-1β, inflammatory IL-23 and IFN-γ, as well as anti-inflammatory IL-10 and IL-12p70. This study demonstrates the robustness and feasibility of complex next generation skin models for investigating skin immunotoxicity.