bluuebunny/crossref_metadata_2025 huggingface dataset:
PRODUCT CATEGORY: A Success Determinant for Store Brands
Authors: Rzem Heifa , Chtioui Rached , Debabi Mohsen
Published: October 2021

This paper examines the influence of product category characteristics on attitude towards store brands (SB). Our aim is to uncover the extent to which change in category quality, category complexity, category familiarity and category risk explain attitude towards store brands and to identify the intermediary role that perceived category risk may play. This study presents the results of a quantitative and a confirmatory analysis conducted on two product categories (detergents and food products). The results confirm the ability of product category to predict attitude towards store brands. Inter-category differences have been noticed, which explain differences in store brands performance from one product category to another.
MOBBING AT BANKS: Moderating Effect of Negative Emotions on the Relationship between Mobbing and Turnover Intention
Authors: Idig-Camuroglu Meltem , Minibas-Poussard Jale
Published: October 2021

While it is not always possible to prevent mobbing in organizations, individuals can be empowered to cope with it by regulating emotions. The purpose of this study was to explore mobbing and turnover intention in banking sector and to examine the moderating effect of negative emotions. Survey approach and free association technique were used with participants who were 164 bank employees in Istanbul, Turkey. Findings revealed that prevalence of mobbing is 30%. The most frequent aggressive behaviors are threats to individual’s personal and work reputation. As the environment is perceived more negative, perceived mobbing increases. With the high levels of mobbing negative emotions increase and turnover intentions arise. Negative emotions moderated the relationship between mobbing and turnover intention. Employees with high negative emotions showed more turnover intention when mobbing increased. Effective coping with mobbing is essential for individuals and organizations since it increases negative affect and turnover intentions in employees. This findings also underlines the importance of anti-bullying policies. To our knowledge, this paper examined the moderating effect of negative emotions on the relationship between mobbing and turnover for the first time.
ПРОБЛЕМЫ КОНСЕРВАЦИИ ОБУГЛЕННОГО ДЕРЕВА (на примере находки с поселения Токсанбай)
Authors: Алтынбеков Кырым , Чарлина Любовь Филипповна , Лошакова Татьяна Николаевна
Published: October 2021

В статье рассматриваются проблемы исследования и консервации объектов из обугленного дерева на примере фрагмента деревянного блюда, обнаруженного при исследовании помещения на северо-восточном склоне поселения Токсанбай (Бейнеуский р-н, Мангистауская обл.) в 2005 г. Раскопки проводились экспедицией Института археологии им. А.Х. Маргулана под руководством З. Самашева, при участии А.С. Ермолаевой в рамках государственного стратегического проекта «Культурное наследие». В статье на конкретном примере дана оценка действий специалистов-археологов; показаны этапы работы специалистов-реставраторов. Даются рекомендации по работе с предметами из деградированных материалов. При исследовании памятника археологами, как правило, проводится полный комплекс мероприятий по фиксации вещных объектов. Предметы из деградирующих материалов требуют особого подхода в извлечении и хранении. В полевых условиях исследователи, при проведении полевой консервации ослабленных предметов, используют подручные материалы, часто это химические составы и не всегда в наличии имеются нужные, применение которых целесообразно в конкретном случае. Деревянное блюдо из жилища поселения Токсанбай относится к категории «обугленное дерево». Предмет из древесины горел без доступа воздуха, его первоначальная структура разрушилась, однако воздействие огня, в данном случае, стало тем консервирующим фактором, который позволил частично сохранить форму предмета. После проведения комплекса консервационно-реставрационных работ блюдо помещено на хранение в фонды Национального музея Республики Казахстан (г. Нур-Султан).
USO DO BRINQUEDO E O COMPORTAMENTO DA CRIANÇA EM ODONTOPEDIATRIA
Authors: Cavalcante Maria Eduarda Werneck , Cortellazzi Karine Laura , Raven Fernanda Gabriele da Costa , Possobon Rosana de Fátima
Published: October 2021

Introdução: Para melhorar a relação profissional de saúde-paciente infantil, o Centro de Pesquisa e Atendimento Odontológico para Pacientes Especiais (Cepae – FOP - Unicamp) instituiu a figura da mascote, animal de brinquedo carregado pelo profissional, usado para interagir com a criança. Objetivo: Investigar a percepção de pais/acompanhantes sobre mudanças comportamentais dos pacientes do CepaeFOP-Unicamp, comparando sessões antes e depois da adoção do Mascote pela Equipe. Material e Métodos: Participaram do estudo 66 pais/acompanhantes de crianças (12-60 meses) atendidas em 2019 e 2020. Por meio de entrevista, os pais/ acompanhantes relataram as manifestações comportamentais da criança na interação inicial com o profissional, durante antropometria e na consulta odontológica, comparando sessões anteriores ao uso do Mascote com a sessão recém-encerrada. Para as comparações entre os dados antes e depois do Mascote aplicou-se o teste de McNemar (SAS, significância de 5%). Resultados: Antes do Mascote, 31,8%, 50,0% e 60,6% das crianças não colaboravam nas 3 fases observadas, sendo que 30,3% requeriam estabilização protetiva para evidenciação de placa e 37,9% choravam durante escovação realizada pela mãe no consultório. Após o uso do Mascote, todas passaram a colaborar. Conclusão: O uso da mascote contribuiu para a melhoria do comportamento da criança em todas as etapas do atendimento observadas.
Peningkatan Literasi Media pada Guru Sekolah Luar Biasa Yayasan Rehabilitasi Tuna Rungu Wicara Surakarta
Authors: Al Irsyadi Fatah Yasin , Gunawan Dedi , Santoso Budi , Kurniawan Yogiek Indra
Published: October 2021

Sekolah Luar Biasa (SLB) Yayasan Rehabilitasi Tuna Rungu Wicara (YRTRW) Surakarta adalah sekolah dasar untuk pendidikan anak dengan keterbatasan berupa tuna rungu wicara satu-satunya di kota Surakarta, Jawa Tengah. Berdasarkan observasi serta wawancara yang telah dilakukan, terdapat permasalahan di Sekolah tersebut, yaitu mengenai kurangnya literasi terhadap media. Solusi yang dapat diberikan di SLB YRTRW Surakarta adalah dengan pelatihan literasi media dari ahli untuk para guru dan staf di SLB tersebut. Pelatihan dilakukan secara daring menggunakan media zoom. Berdasarkan hasil analisa terhadap kegiatan yang telah dilakukan, terdapat rata-rata peningkatan pengetahuan dari peserta sebesar 41,5625%. Hal ini menunjukkan kegiatan pelatihan yang dilakukan telah berhasil untuk meningkatkan pengetahuan dari peserta mengenai Teknik penulisan berita, Teknik pengolahan media, cara pengelolaan website serta literasi media.
Sistem Informasi Panduan Diet Bagi Penderita Obesitas Berbasis Website
Authors: Rizaldi Sigit , Nugroho Arief Kelik , Chasanah Nur
Published: October 2021

Obesitas adalah suatu keadaan yang terjadi apabila jumlah lemak tubuh dibandingkan dengan berat badan total lebih besar dari pada normal. Banyak dikalangan remaja hingga dewasa yang mengalami penyakit obesitas. Dengan penyakit yang mereka alami, tentunya mereka akan berinisiatif untuk melakukan program diet untuk menghilangkan obesitas. Adapun masalah yang terjadi adalah banyak dari sekian orang yang belum mengerti tentang diet sehat. Diet sehat adalah suatu aturan dalam pola makan untuk tujuan tertentu. Berdasarkan permalahan tersebut maka dilakukan penelitian yang berjudul “Rancang Bangun Sistem Informasi Panduan Diet Bagi Penderita Obesitas berbasis  Website”. Tujuan dari penelitian ini adalah merancang sistem informasi berbasis web yang dapat membantu para obesitas untuk bisa melakukan program diet dengan baik dan benar. Sistem dibuat dengan menggunakan bahasa pemrograman HTML, CSS, PHP, dan MySQL serta penelitian ini menggunakan metode pengembangan waterfall dan metode pengujian yang digunakan Blackbox dan Mean Opinion Score (MOS). Hasil pengujian sistem berdasarkan pengujian MOS 90% responden menyatakan bahwa sistem panduan diet bagi penderita obesitas dapat membantu dalam menjalankan program diet dengan baik, dan hasil pengujian blackbox sistem berjalan dengan baik sesuai ketentuan pengujian pada sistem.
Game Edukasi Belajar Huruf Hijaiyah Untuk Anak Kelas 2 di Sekolah Luar Biasa Yayasan Rehabilitasi Tuna Rungu Wicara Surakarta
Authors: Al Irsyadi Fatah Yasin , Susanti Lia Dewi , Kurniawan Yogiek Indra
Published: October 2021

Sekolah Luar Biasa Yayasan Rehabilitasi Tuna Rungu Wicara  (SLB YRTRW) Surakarta merupakan tempat belajar bagi anak berkebutuhan khusus terutama bagi anak tuna rungu wicara yang memiliki banyak permasalahan dalam proses belajar mengajar di sekolah. Kelas yang tidak kondusif akan mempengaruhi kenyamanan dan ketertarikan anak-anak dalam belajar. Guru Pendidikan Agama Islam (PAI) di SLB hanya ada satu yang mengampu dari sekolah dasar sampai sekolah menengah atas sehingga siswa perlu mengulang kembali pelajaran saat di rumah. Penelitian ini bertujuan untuk merancang bangun aplikasi belajar huruf hijaiyah untuk anak tuna rungu.Penelitian ini dilakukan berdasarkan kurikulum SLB YRTRW terutama kurikulum sekolah dasar kelas 2.Berdasarkan wawancara dan observasi yang didampingi oleh guru PAI aplikasi ini mencakup kemampuan siswa tuna rungu dan mensimulasikan cara mengajar guru PAI ke media digital. Aplikasi ini akan beroperasi pada perangkat smartphone android yang hampir setiap orang miliki saat ini.Aplikasi ini dibuat menggunakan Construct 2 yang akan diubah ke versi android menggunakan software aplikasi Cordova dan Cocoon.io. Pembuatan asset game menggunakan aplikasi Corel Draw. Hasil dari penelitian ini berupa aplikasi game edukasi “Mari Belajar Huruf Hijaiyah” untuk anak tuna rungu. Game edukasi ini memiliki sesi belajar huruf hijaiyah yang dilengkapi dengan isyarat tangan. Pengujian aplikasi dilakukan dengan cara memberikan aplikasi pada siswa-siswi tuna rungu dan mencobanya secara langsung. Berdasarkan hasil kuisioner yang diisi langsung oleh siswa tuna rungu dengan bimbingan guru PAI  dapat disimpulkan bahwa aplikasi ini menarik dan  efektif untuk meningkatkan kemampuan anak belajar huruf hiijaiyah.
Randomized solid state bulk functionalization of aramid fiber pulp and its application in elastomer compositions
Authors: Hanifa Sheik Mohammed , Venkatakrishnan Subrahmanian
Published: October 2021

N‐oxydiethylene‐2‐benzothiazole sulphenamide (NOBS) dispersed in an inert (saturated main chain) rubber matrix (ethylene‐co‐propylene‐diene monomer [EPDM], as carrier to be dispersed later in a predetermined lower quantities) containing definite amount of pre‐dried aramid fiber pulp (AP) was subjected to internal thermal influence as heated through dielectric‐dielectric interaction in a laboratory microwave oven. The reactions of NOBS with aramid fiber pulp (on the surface and in the bulk) were characterized using XPS, TGA, FTIR, SEM, and mechanical properties. The objective was to confirm the efficacy of dielectric heating in situ and to promote functionality for bonding with rubber. The functionalization was considered to be provided by NOBS. One such chemical modification was found to be the generation of free ends in the AP and it was characterized by XPS. At the same time, there was no thermal degradation as confirmed from TGA studies. The rubber‐AP masterbatch (as previously prepared was dispersed) in different proportions in Butadiene‐co‐acrylonitrile rubber (NBR) and various characterizations related to plain rubber compound and in the cross linked states including fluid barrier properties and spring characteristics were found to record a significant improvement. The SEM micrographs showed that the fiber‐rubber cohesion and the rubber‐AP interaction are enhanced due to the proposed dielectric heating induced functionalization of AP.
Effects of wheat debranning on the sensory quality and antioxidant activity of Chinese steamed bread
Authors: Sun Yue , Liu Yuqian , Zhang Jinli , Liu Jing , Hou Hanxue
Published: October 2021

Background and objectives

Although bran‐enriched foods are rich in bioactive compounds, the bioaccessibility of these bioactive compounds and their antioxidant activity after digestion in Chinese steamed bread (CSB) are poorly understood. The effects of wheat debranning on the sensory quality of CSB and antioxidant activity after digestion were studied, in order to provide special foods with different bran content for the consumers with diverse healthy status.

Findings

For CSB, wheat debranning improved the color, textural properties, and sensory score but reduced the antioxidant activity and total phenolic content (TPC). After in vitro digestion, the TPC and antioxidant activity of the chyme‐soluble fraction (CSF) reached the highest value at degrees of debranning between 3% and 7%. Compared with debranning process, the effects of in vitro digestion on antioxidant activity were more significant.

Conclusions

Degrees of debranning between 3% and 7% can offer the highest nutritional value of CSB. Although debranning process had some effects on the TPC and antioxidant activity of CSB, they were very limited when compared with those of digestion. The bran recombination process was better for the preparation of CSB than direct ground process.

Significance and novelty

In addition to sensory qualities, this study also investigated the effects of digestion on the release of antioxidant activity of CSB with different degrees of debranning. Since the total antioxidant activity only slightly decreased after debranning of 0‐16% degrees, intaking CSB with lower bran content may also have considerable healthy benefit.
Diagnostic tools should be used for the diagnosis of chemotherapy induced peripheral neuropathy in breast cancer patients receiving taxanes
Authors: van Haren Frank , van den Heuvel Sandra , Ligtenberg Mandy , Vissers Kris , Steegers Monique
Published: October 2021

Background

Though the incidence, characteristics, and pathogenesis of chemotherapy induced peripheral neuropathy (CIPN) by taxane based chemotherapy were extensively studied, diagnostic guidelines extent only recently.

Aim

To observationally investigate whether specific tests can be used to predict and monitor CIPN severity.

Methods

Fourteen female breast cancer patients receiving paclitaxel or docetaxel were evaluated using the McGill Pain Questionnaire (MPQ), National Cancer Institute Common Toxicity Criteria (NCI‐CTC) grading, clinical total neuropathy score (TNSc), quantitative sensory testing (QST) of pressure pain threshold (PPT), and numeric rating scale (NRS) scores and stocking and glove distribution testing (SGDT), at the start (T0), midst (T1), and end (T2) of their treatment and after 3 months (T3).

Results

At T3, patients scored NCI‐CTC neuropathy grade 1 (14.3%), 2 (64.3%), and 3 (14.3%) respectively. Fifty percentage scored at least grade 1 at T0, with complaints not caused by CIPN. Pain, if present, was denominated “tingling” and “cold” in the MPQ. Median TNSc score increased from T0 (2.43) to T1 (4.71) to T2 (5.50) to T3 (5.57), as did pinprick and cold sensation disturbances in SGDT. PPT and associated NRS remained unchanged. TNSc and SGDT at T1 could not predict the NCI‐CTC grade at T3.

Conclusion

NCI‐CTC, TNSc, and stocking and glove distribution testing can be used in the early diagnosis and monitoring of CIPN, with false‐positive findings at baseline. Final NCI‐CTC grades could not be predicted.
Screening for diabetic retinopathy with fluorescein angiography in patients with type 1 diabetes from adolescence to adult life. A retrospective study of the past 30 years of clinical practice in a tertiary Belgian centre
Authors: Conti Gwendolina , Postelmans Laurence , Dorchy Harry
Published: October 2021

Background

The aim of the present study was to describe the prevalence and progression of DR diagnosed by fluorescein angiography (FA) in patients with type 1 diabetes (T1D) during a 30‐year follow‐up, and the relationship with glycated haemoglobin (HbA1c).

Materials and methods

We included 4325 FA reports representing 851 patients with T1D with a mean age at diagnosis of 10.4 years (range: 0.0–49.9) and followed between 1986 and 2015. Clinical characteristics of the population were collected from patients’ files. The HbA1c level was measured within a maximum period of ±1 year from the date of FA. Descriptive statistics were realized to study prevalence and progression of DR.

Results

At diagnosis of incipient abnormalities, mean age was 22.8 years (range 13.7–46.9) and mean diabetes duration was 13 years (range: 4.3–29.6). Lesions requiring treatment were observed in 5.9% of the patients at a mean age of 32.4 years (range: 30.4–34.3) and a mean diabetes duration of 23.8 years (range: 19.4–28.1). On average, it took 12.9 years (range: 12.2–13.5) to progress from an incipient abnormality to a lesion requiring treatment. Mean HbA1c ± SD was 7.8 ± 1.5% over a period of 30 years.

Conclusions

While it could have been expected to observe a higher prevalence of DR, our study described by far the lowest results of prevalence comparing to similar studies, probably due to a good average HbA1c over 30 years.
N‐myc downstream regulated family member 1 (NDRG1) is enriched in myelinating oligodendrocytes and impacts myelin degradation in response to demyelination
Authors: Marechal Damien , Dansu David K. , Castro Kamilah , Patzig Julia , Magri Laura , Inbar Benjamin , Gacias Mar , Moyon Sarah , Casaccia Patrizia
Published: October 2021

The N‐myc downstream regulated gene family member 1 (NDRG1) is a gene whose mutation results in peripheral neuropathy with central manifestations. While most of previous studies characterized NDRG1 role in Schwann cells, the detection of central nervous system symptoms and the identification of NDRG1 as a gene silenced in the white matter of multiple sclerosis brains raise the question regarding its role in oligodendrocytes. Here, we show that NDRG1 is enriched in oligodendrocytes and myelin preparations, and we characterize its expression using a novel reporter mouse (TgNdrg1‐EGFP). We report NDRG1 expression during developmental myelination and during remyelination after cuprizone‐induced demyelination of the adult corpus callosum. The transcriptome of Ndrg1‐EGFP+ cells further supports the identification of late myelinating oligodendrocytes, characterized by expression of genes regulating lipid metabolism and bioenergetics. We also generate a lineage specific conditional knockout (Olig1cre/+;Ndrg1fl/fl) line to study its function. Null mice develop normally, and despite similar numbers of progenitor cells as wild type, they have fewer mature oligodendrocytes and lower levels of myelin proteins than controls, thereby suggesting NDRG1 as important for the maintenance of late myelinating oligodendrocytes. In addition, when control and Ndrg1 null mice are subject to cuprizone‐induced demyelination, we observe a higher degree of demyelination in the mutants. Together these data identify NDRG1 as an important molecule for adult myelinating oligodendrocytes, whose decreased levels in the normal appearing white matter of human MS brains may result in greater susceptibility of myelin to damage.
In vitro recovery of FIX clotting activity as a marker of highly functional hepatocytes in a hemophilia B iPSC model
Authors: Luce Eléanor , Steichen Clara , Allouche Mickaël , Messina Antonietta , Heslan Jean‐Marie , Lambert Thierry , Weber Anne , Nguyen Tuan Huy , Christophe Olivier , Dubart‐Kupperschmitt Anne
Published: October 2021

Background and Aims

Pluripotent stem cell–derived hepatocytes differentiated in monolayer culture are known to have more fetal than adult hepatocyte characteristics. If numerous studies tend to show that this immature phenotype might not necessarily be an obstacle to their use in transplantation, other applications such as drug screening, toxicological studies, or bioartificial livers are reliant on hepatocyte functionality and require full differentiation of hepatocytes. New technologies have been used to improve the differentiation process in recent years, usually evaluated by measuring the albumin production and CYP450 activity. Here we used the complex production and most importantly the activity of the coagulation factor IX (FIX) produced by mature hepatocytes to assess the differentiation of hemophilia B (HB) patient’s induced pluripotent stem cells (iPSCs) in both monolayer culture and organoids.

Approach and Results

Indeed, HB is an X‐linked monogenic disease due to an impaired activity of FIX synthesized by hepatocytes in the liver. We have developed an in vitro model of HB hepatocytes using iPSCs generated from fibroblasts of a severe HB patient. We used CRISPR/Cas9 technology to target the genomic insertion of a coagulation factor 9 minigene bearing the Padua mutation to enhance FIX activity. Noncorrected and corrected iPSCs were differentiated into hepatocytes under both two‐dimensional and three‐dimensional differentiation protocols and deciphered the production of active FIX in vitro. Finally, we assessed the therapeutic efficacy of this approach in vivo using a mouse model of HB.

Conclusions

Functional FIX, whose post‐translational modifications only occur in fully mature hepatocytes, was only produced in corrected iPSCs differentiated in organoids. Immunohistochemistry analyses of mouse livers indicated a good cell engraftment, and the FIX activity detected in the plasma of transplanted animals confirmed rescue of the bleeding phenotype.
Proteomics analysis reveals digestion‐resistant proteins from colostrum are associated with inflammatory and cytotoxic responses in intestinal epithelial cells
Authors: Chen Yimin , Kim Bum Jin , Dallas David C.
Published: October 2021

Background

Although human‐milk feeding reduces the risk of necrotizing enterocolitis (NEC) in preterm infants compared with formula feeding, the exact risk‐reduction mechanism remains unknown. As NEC occurs at the distal small intestine in which digestion has occurred, we applied proteomics to examine the extent to which colostrum proteins survive simulated infant in vitro–digestion and, thus, have potential to exert biological function.

Methods

Ten preterm colostrum samples were left undigested or in vitro–digested, and lipopolysaccharide (LPS)‐binding protein, soluble cluster of differentiation 14, and tumor necrosis factor (TNF) receptors I and II were measured using enzyme‐linked immunosorbent assay in all undigested and in vitro–digested samples. Fully differentiated Caco‐2 cells were exposed to digested colostrum samples before stimulation with LPS or TNF or no stimulation. Inflammation (interleukin‐8) and cytotoxicity (lactate dehydrogenase) were measured. Proteomic analyses of undigested and in vitro–digested samples were done using mass spectrometry.

Results

We found that most proteins in colostrum are significantly, if not completely, degraded after in vitro–digestion. We found select individual and combination digestion‐resistant proteins that were positively correlated with LPS‐ and TNF‐induced inflammation.

Conclusion

These results indicate the importance of considering the extent to which specific dietary compounds survive digestion to reach their site of claimed action (distal intestine) and that some digestion‐resistant proteins may be contributing toward “low‐grade” inflammation that is necessary to promote intestinal growth and maturation during early infancy. This work provides the most detailed understanding of human‐milk protein degradation with simulated infant in vitro–digestion to date.
A Novel Adenoidectomy Training System
Authors: Molin Nicole , Wang Nigel , Isaacson Glenn
Published: October 2021

Objectives/Hypothesis

Young residents find mirror‐guided adenoidectomy difficult. Inexperienced trainees must learn to focus a headlight beam, work upside‐down and backward in a small space and thoroughly ablate adenoid tissue—all new skills. We present an adenoidectomy training system that is low‐cost, easy to construct, and is focused on these basic adenoidectomy skills.

Study Design

Prospective experimental study.

Methods

This training suite includes three stations each targeting a different skill. The first employs a mannequin head with exposed nasopharynx. It trains the student to coordinate a headlight and mirror while touching a series of targets with a curved probe. At the second station participants electrodessicate (or microdebride) an anchored piece of veal thymus. The third station combines both sets of skills as participants ablate thymus in a simulated nasopharynx (30 mm rectangular aluminum tube) constrained within a Crow‐Davis retractor, using a headlight, mirror, and suction electrosurgical electrode (or microdebrider). To evaluate the training system's efficacy, we assessed the performance of 10 surgically naïve medical student volunteers before and after 15 minutes of practice using a validated rating scale used for adenoidectomy.

Results

There was significant improvement in adenoidectomy skill scores after practicing. Overall scores were higher, time taken to touch a series of targets with a headlight and mirror was less and amount of tissue ablated at the final station was greater (P < .05).

Conclusion

This novel adenoidectomy training system is inexpensive and easy to build. Practice with the model resulted in statistically significant improvement in adenoidectomy skill scores for inexperienced student surgeons.

Level of Evidence

3 Laryngoscope, 132:2056–2062, 2022
Use of antidepressants and risk of repeat self‐harm in older adults 75+ with nonfatal self‐harm: A 1‐year prospective national study
Authors: Hedna Khedidja , Montuori Chiara , Forte Alberto , Pompili Maurizio , Waern Margda
Published: October 2021

Purpose

To assess exposure to antidepressants (AD) before and after nonfatal self‐harm (SH) in older adults and to examine 1‐year rates and risk factors for subsequent SH.

Methods

Longitudinal national register‐based retrospective cohort study of Swedish residents aged 75+ (N = 2775) with treatment at hospital or specialist outpatient clinic in connection with SH between January 1, 2006, and December 31, 2013. The cohort was followed for 1 year after the index episode. Exposure to AD was assessed at index and at subsequent SH. Cox regression analysis was used to assess factors associated with 1‐year repeat SH.

Results

At the index episode, 51% were prevalent AD users; 23% started AD during the following year. Overall 12% of prevalent AD users, 8% of AD nonusers, and 6% of AD new users repeated SH or died by suicide. About two‐thirds of these subsequent behaviors occurred within 3 months after the index episode. Men had increased risk of subsequent SH (Hazard ratio [HR] 1.38, 95% CI: 1.09–1.74); older age (>85 years) was associated with a lower risk (HR 0.72, CI 95% 0.55–0.93). Users of AD did not have an increased risk of repeat SH.

Conclusions

Half of older adults who self‐harmed were prevalent AD users and a further one fourth started an AD within 1 year after the index SH. Antidepressant use was not associated with increased risk of subsequent SH in this high‐risk cohort of older adults.
Soil phosphomonoesters in large molecular weight material comprise multiple components
Authors: McLaren Timothy I. , Verel René , Frossard Emmanuel
Published: October 2021

The majority of soil organic P is typically that of “unresolved” phosphomonoesters, which are associated with organic P (Po) in large molecular weight (MW) fractions. However, the composition of this pool of Po remains unclear and could contain more than one component. Our aim was to identify the number and nature of components in soil extracts of different MW using solution 31P nuclear magnetic resonance (NMR) spectroscopy and spectral deconvolution fitting. Three surface soils were collected from native sites, which were extracted for Po using 0.25 M NaOH + 0.05 M Na2–EDTA (unfractionated), followed by size separation using ultrafiltration, resulting in four MW fractions (>10 kDa, <10 kDa, <10 kDa and >3 kDa, and <3 kDa). The NMR analyses revealed a diversity of Po species in all MW fractions across the three soils. In particular, the phosphomonoester region of the >10‐kDa fraction comprised up to 10 components of varying linewidth (0.5–18.6 Hz) and a broad signal (228 Hz). This broad signal was also present in the <3‐kDa fraction, albeit at a lower concentration (average was 29% of that in the unfractionated extracts). Furthermore, solution 31P NMR spectra on the <3‐kDa fraction revealed a diversity of sharp signals (up to 28) in the phosphomonoester region. Overall, our findings show that soil phosphomonoesters in large MW fractions comprise multiple components of varying linewidth.
Potential of Hibiscus sabdariffa Linn. in managing FGF21 resistance in diet‐induced‐obesity rats via miR‐34a regulation
Authors: Kartinah Neng Tine , Komara Nisa , Noviati Nuraini Diah , Dewi Syarifah , Yolanda Sophie , Radhina Afifa , Heriyanto Heriyanto , Sianipar Imelda Rosalyn
Published: October 2021

Background

Obesity is a cause of FGF21 resistance, which affects the browning and thermogenesis process of the adipose tissue. Decreased receptor expression is influenced by miR‐34a, whose expression is increased in obesity. While FGF21‐based therapies have been widely investigated, the potential activity of Hibiscus sabdariffa Linn. extract (HSE) against FGF21 resistance is unknown.

Objective

This study aims to determine the effects of HSE on the expression of miR‐34a and FGF21 receptors in white adipose tissue.

Methods

This experimental study used 24 male Sprague‐Dawley rats and divided into four groups: Control (N); diet‐induced‐obesity rats (DIO); DIO rats with HSE 200 mg/kgBW/day and DIO rats with HSE 400 mg/kgBW/day. Rats were fed a high‐fat diet for 17 weeks. HSE was administered daily for 5 weeks. The administration of HSE 400 mg/kgBW/day resulted in the equivalent expression of miR‐34a to that of the control (p > 0.05).

Results

FGFR1 receptor expression was also similar to controls (p > 0.05). Beta‐klotho expression was significantly lower than that of control (p < 0.05) but equivalent to that of DIO rats (p < 0.05).

Conclusions

H. sabdariffa has the potential to reduce FGF21 resistance in DIO rats through the suppression of miR‐34a expression and an increase in the number of FGFR1 and beta‐klotho receptors in adipose tissue.
How to Do a Review of the Literature?
Authors: Nundy Samiran , Kakar Atul , Bhutta Zulfiqar A.
Published: October 2021

In scientific writing, whether it is a research paper, thesis, or dissertation, it is important to investigate a problem that has not been tackled before—that is, to fill a gap in the current knowledge. The first question an editor or reviewer asks after seeing a submission is ‘Why did the authors do the work, is the subject original?’
How to Write Results?
Authors: Nundy Samiran , Kakar Atul , Bhutta Zulfiqar A.
Published: October 2021

Observations are usually tabulated, graphed, or charted after conducting a study. The interpretation of the observations is called the results.
How to Write the Discussion?
Authors: Nundy Samiran , Kakar Atul , Bhutta Zulfiqar A.
Published: October 2021

Many authors, and editors, think this is the most difficult part of a paper to write well and have described it variously to be the ‘narrating the story of your research’, ‘the movie or the main scientific script’ and the ‘proof of the pudding’. The idea of a discussion is to communicate to the readers the importance of your observations and the results of all your hard work. In this section, you are expected to infer their meaning and explain the importance of your results and finally provide specific suggestions for future research [1, 2]. The discussion places the outcome into a larger context and mentions the implications of the inferences for theoretical and practical purposes [3].
How to Cite Other Papers and Add References?
Authors: Nundy Samiran , Kakar Atul , Bhutta Zulfiqar A.
Published: October 2021

Citation means acknowledging and documenting the source of information that has been used in a study [1]. Citations are given in the text of the manuscript to be prepared. There are three common ways to cite an article which are given below.
How to Do a Peer Review?
Authors: Nundy Samiran , Kakar Atul , Bhutta Zulfiqar A.
Published: October 2021

Peer review is a process in which a paper’s validity, originality and academic content are checked prior to publication in a good journal. In other words, it is ‘evaluation of work by one or more people with similar competencies’. The people who carry out this work are called reviewers or referees [1].
How to Handle Rejection?
Authors: Nundy Samiran , Kakar Atul , Bhutta Zulfiqar A.
Published: October 2021

The most important reason for immediate rejection is that the authors have not complied with all the necessary requirements of the journal. The submission of auxiliary documents that are necessary (ethics, conflict of interest) may have not been sent. The Editor in charge first looks at the title and the topic of the research [1, 2]. When he feels that it may not have much interest to his readers, the paper can be directly sent back at this level.
How to Conduct a Journal Club?
Authors: Nundy Samiran , Kakar Atul , Bhutta Zulfiqar A.
Published: October 2021

Reading journals usually starts when you are a postgraduate and a journal club forms an important part of your curriculum. A journal club is a meeting that should be attended by all faculty and trainees. Your mentor will decide which journal articles you should get ready to present and discuss.
The Status of Biomedical Research in Some Developing Countries
Authors: Nundy Samiran , Kakar Atul , Bhutta Zulfiqar A.
Published: October 2021

The International Monetary Fund (IMF) and the United Nations (UN) have both defined developing nations but depend on the country itself to declare whether or not it is still not developed. The Human Development Index (HDI) is easier to understand and is a comparative measure of four parameters—life expectancy, literacy, education, and standards of living for regions worldwide. Countries fall into four broad categories based on their HDI: very high (for developed countries), high and medium (for developing countries), and low (for least developed countries). Alternative classification exists based on the Gross Domestic Product which can classify countries into high- medium-, and low-income group. In this article however, will used the HDI criteria of 2019 for our discussion [1].
Emissionshandel als Leitinstrument für eine effektive und effiziente EU-Klimapolitik im Verkehr
Authors: Eisenkopf Alexander , Knorr Andreas
Published: October 2021

Das oberste klimapolitische Ziel der EU ist die vollständige Dekarbonisierung der Wirtschaft ihrer Mitgliedsstaaten bis 2050, d. h. die Klimaneutralität in allen Sektoren, die derzeit noch von fossilen Brennstoffen abhängig sind. Dies spiegelt sich in der politischen Agenda der EU-Kommission unter dem Titel „European Green Deal“ wider. Um die Klimaneutralität bis 2050 zu erreichen, wurde das bisherige CO2-Zwischenziel der EU kürzlich von 40 % auf 55 % Reduktion bis 2030 verschärft. Im unlängst angekündigten „Fit for 55“-Programm hat die Kommission umfassende Reformen des EU-Emissionshandelssystems, der Erneuerbare-Energien-Richtlinie und der Energiesteuerrichtlinie vorgeschlagen, um den European Green Deal vollständig umzusetzen. Die vorgeschlagenen Maßnahmen werden kritisch bewertet.
Correlation of exercise-induced peripheral venous hypertension with exercise intolerance in patients with Fontan circulation
Authors: Ono Shin , Yanagi Sadamitsu , Wakamiya Takuya , Ichikawa Yasuhiro , Kawai Shun , Kim Ki-Sung , Ueda Hideaki
Published: October 2021

Owing to the absence of a sub-pulmonary ventricle, the central venous pressure rises in patients with Fontan circulation. During exercise, central venous pressure may rise further to increase the systemic ventricular preload and cardiac output. We performed a single-centre prospective trial of cardiopulmonary exercise test while monitoring peripheral venous pressure which strongly correlates with central venous pressure. The objective of this study was to test the hypothesis that peripheral venous pressure at peak exercise inversely correlates with exercise capacity in patients with Fontan circulation. Seventeen patients following Fontan operation performed cardiopulmonary exercise test while monitoring peripheral venous pressure. Peak oxygen uptake, heart rate reserve, peak oxygen pulse (divided by body surface area), and peripheral venous pressure at peak exercise were measured. Correlations of peripheral venous pressure at peak exercise with the peak oxygen uptake, heart rate reserve, and peak oxygen pulse were evaluated. The peripheral venous pressure at peak exercise inversely correlated with the peak oxygen uptake (R = −0.66, p < 0.01), heart rate reserve (R = −0.6, p < 0.05), and peak oxygen pulse (R = −0.48, p < 0.05). Exercise-induced peripheral venous hypertension correlates with exercise intolerance in patients with Fontan circulation. Peak oxygen uptake is a useful index for evaluating the status of congestion in the daily life of patients with Fontan circulation.
Hochleistungsmedizin ein Gesicht geben
Authors: Graffe Julian
Published: October 2021

Kanäle wie Facebook, Instagram und Co. sind fester Bestandteil einer modernen Krankenhauskommunikation. Aber was macht die Arbeit auf diesen Plattformen so besonders – gerade für einen Maximalversorger wie das Universitätsklinikum Münster? Der medizinische Kontext hält zwar einige Risiken und Fallstricke bereit. Diese fallen jedoch bei einem genaueren Blick deutlich zurück hinter den großen Potenzialen der von Videos und Fotos getriebenen Kommunikation.
Quantitative Studiendesigns: Harte Daten erfassen
Authors: Mehrholz Jan
Published: October 2021

Was ist eigentlich quantitative Forschung? Man könnte sagen, dass alle Studien, in denen man Daten erhebt und anschließend auswertet, quantitative Studien sind. Der Artikel erläutert, wie komplex die Studiendesigns und deren Methoden sind.
Perinataler Verlust eines Kindes – die Perspektive der
Väter
Authors: Jux Chantal , Tiesmeyer Karin , Knecht Christiane
Published: October 2021

Eine Fehl- oder Totgeburt ist eine tiefgreifende Erfahrung im Leben von
Eltern. Obwohl diese die ganze Familie betrifft, stehen auch in Bezug auf
das professionelle Handeln die Mütter im Vordergrund. Doch auch
Väter erleben den Verlust eines Kindes auf individuelle Weise und
haben eigene Bedürfnisse, die gesehen und berücksichtigt
werden sollten. In der hier vorgestellten Literaturstudie wird das Erleben
und Bewältigungshandeln von Vätern dargestellt, die mit dem
perinatalen Verlust eines Kindes konfrontiert wurden.
Einkauf als Motor der Innovation: Integriertes Management der Aortenstenose am Uniklinikum Barcelona
Authors: Fellner Dieter
Published: October 2021

Eine auf Qualitätsziele und Langfristigkeit ausgerichtete Zusammenarbeit, welche die Projektpartner früh und verbindlich einbindet, steht im Zentrum des Projekts MITMEVA zur Behandlung von Aortenstenosen am Uniklinikum in Barcelona. Der Behandlungsauftrag setzt weit vor der Krankenhausaufnahme an und geht weit über die Hightech-OP hinaus.
Logistische Versorgungsinhalte für Krankenhäuser: Operativer Wareneinkauf für Krankenhäuser durch einen logistischen Dienstleister
Authors: Jaeger Thomas
Published: October 2021

Wenn Krankenhäuser zur logistischen Versorgung in der Basis eine Lagerhaltung und eine Transportlogistik an einen externen Dienstleister übertragen, kann von den meisten Anbietern im Gesundheitsmarkt hiermit in Verbindung gleichzeitig auch die operative Warenbeschaffung für das ausgelagerte Produktsortiment mit übernommen werden.
Medikation: Optimale Abläufe dank smarter Hilfsmittel
Authors: Trimpin Jan
Published: October 2021

Dieser Artikel ist nur als PDF-Dokument verfügbar.
Aufbereitung von Medizinprodukten: Quälitatssicherung im Rahmen einer Servicegesellschaft
Authors: Schneider Kyra , Wagner Jörg
Published: October 2021

Dieser Artikel ist nur als PDF-Dokument verfügbar.
Role of nurses in managing menstrual health using mobile tracking
Authors: Sanchez Barbara N. , Maresh Carl M.
Published: October 2021

Mobile technologies provide a unique opportunity to improve menstrual health awareness, management, and care. Nurses should consider incorporating a mobile tracking component into patient-care settings to promote menstrual health awareness and advocacy and to help create individualized healthcare plans.
Reversible Corneal Decompensation Caused by a Topical Dorzolamide/Timolol Fixed Combination After Descemet Stripping Automated Endothelial Keratoplasty
Authors: Kwak Jeeyoung , Jun Jong Hwa
Published: October 2021

Purpose:

The purpose of this study was to report a case of acute corneal endothelial decompensation caused by a topical dorzolamide/timolol fixed combination (DTFC) after Descemet stripping automated endothelial keratoplasty.

Methods:

A 75-year-old woman who was referred to our hospital with a chief complaint of visual disturbance in the right eye after cataract surgery. Anterior segment optical coherence tomography identified an extensive defect in Descemet membrane. The patient subsequently underwent uneventful Descemet stripping automated endothelial keratoplasty surgery for persistent corneal edema. Two weeks after surgery, she had been prescribed topical DTFC twice daily to control elevated intraocular pressure. On the day she started using the eye drops, the patient noticed an acute deterioration of visual acuity. Severe corneal edema was detected at follow-up 5 days later.

Results:

The topical DTFC was stopped immediately. Thereafter, the corneal edema improved gradually, and there was a reduction in corneal thickness.

Conclusions:

Topical DTFC should be used with caution after corneal endothelial transplantation because of the possibility of iatrogenic corneal endothelial dysfunction.
The Mask-Wearing Bias In The Estimates Of Vaccine Efficacy
Authors: Matytsin Andrew
Published: October 2021

In the United States mask wearing is positively correlated with vaccine acceptance. This correlation introduces an important bias into real-world estimates of vaccine efficacy. I derive the formulae for vaccine efficacy that correct for this phenomenon and show that such biases explain some of the differences between higher estimates of vaccine efficacy observed in the US studies, on one hand, and lower estimates from Israel and Pfizer trials, on the other hand. Control for such biases is important for currently-debated public health decisions regarding COVID19 vaccine booster doses.
Nanoviricides Platform Technology based NV-387 polymer Protects Remdesivir from Plasma-Mediated Catabolism in vitro: Importance of its increased lifetime for in vivo action
Authors: Chakraborty Ashok , Diwan Anil , Arora Vinod , Thakur Yogesh , Holkar Preetam , Chinige Vijetha
Published: October 2021

As of today seven coronaviruses were identified to infect humans, out of which only 4 of them belongs to beta family of coronavirus, like HCoV-HKU1, SARS-CoV-2, MERS-CoV and SARS-CoV. SARS family of viruses were known to cause severe respiratory disease in humans. SARS-CoV-2 infection causes pandemic COVID-19 disease with high morbidity and mortality. Remdesivir (RDV) is the only antiviral drug so far approved for Covid-19 therapy by FDA. However it’s efficacy is limited in vivo due to it’s low stability in presence of Plasma.

Here we show the stability of RDV encapsulated with our platform technology based polymer NV-387 (NV-CoV-2-R), in presence of Plasma in vitro in comparison to naked RDV when incubated in plasma. The potential use of this polymer in vivo will be discussed, here.
MutS and DNA Function as a Clamp Loader for the MutL Sliding Clamp During Mismatch Repair
Authors: Yang Xiao-Wen , Han Xiao-Peng , Han Chong , London James , Fishel Richard , Liu Jiaquan
Published: October 2021

DNA mismatch repair (MMR) is accomplished by highly conserved MutS and MutL homologs. MutS proteins recognize mismatch nucleotides and in the presence of ATP form a stable sliding clamp on the DNA. The MutS sliding clamp then promotes the cascade assembly of a MutL sliding clamp, which ultimately coordinates downstream mismatch excision. The MutS clamp-loader mechanics are unknown. Here we have examined a conserved positively charged cleft (PCC) located on the MutL N-terminal domain (NTD) proposed to mediate stable DNA binding events in several MMR models. We show that MutL does not bind DNA in physiological ionic conditions. Instead, the MutS sliding clamps and DNA together exploit the PCC to position the MutL NTD for clamp loading. Once in a sliding clamp form, the MutL PCC aids in UvrD helicase capture but not interactions with MutH during mismatch excision. The MutS-DNA clamp-loader progressions are significantly different from the replication clamp-loaders that attach polymerase processivity factors such as β-clamp and PCNA to the DNA. These studies underlining the breadth of mechanisms for stably linking crucial genome maintenance proteins to the DNA.
A study on intention to use social media in higher education: the mediating effect of peer influence
Authors: Trivedi Shrawan Kumar , Patra Pradipta , Singh Saumya
Published: October 2021

Purpose

Social media sites are one of the vital technological developments of WEB 2.0. This study aims to emphasize on building an empirical model to investigate the impending determinants of users’ intention to use social media sites in higher education. Depending on the existing theories such as the social media acceptance model, e-learning acceptance model, unified theory of acceptance and use of technology and existing literature, determinants such as “performance,” “communication functionality” and “self” have been identified to test. Further, the mediation effect of “peer influence” on the relationship has also been tested.

Design/methodology/approach

A total of 310 students of different private and public Indian institutions have participated in an online survey. Exploratory factor analysis and multiple linear regression analysis are performed and results were analyzed.

Findings

The results of this study demonstrated substantial evidence of the impact of performance, communication functionality and self on the intention to use social media in higher education. The mediation of peer influence has also been seen between all the relations.

Originality/value

An empirical model of intention to use social media in higher education is built. The median of peer influence is tested.
Lateral stability regulation of intelligent electric vehicle based on model predictive control
Authors: Li Cong , Xie YunFeng , Wang Gang , Zeng XianFeng , Jing Hui
Published: October 2021

Purpose

This paper studies the lateral stability regulation of intelligent electric vehicle (EV) based on model predictive control (MPC) algorithm.

Design/methodology/approach

Firstly, the bicycle model is adopted in the system modelling process. To improve the accuracy, the lateral stiffness of front and rear tire is estimated using the real-time yaw rate acceleration and lateral acceleration of the vehicle based on the vehicle dynamics. Then the constraint of input and output in the model predictive controller is designed. Soft constraints on the lateral speed of the vehicle are designed to guarantee the solved persistent feasibility and enforce the vehicle’s sideslip angle within a safety range.

Findings

The simulation results show that the proposed lateral stability controller based on the MPC algorithm can improve the handling and stability performance of the vehicle under complex working conditions.

Originality/value

The MPC schema and the objective function are established. The integrated active front steering/direct yaw moments control strategy is simultaneously adopted in the model. The vehicle’s sideslip angle is chosen as the constraint and is controlled in stable range. The online estimation of tire stiffness is performed. The vehicle’s lateral acceleration and the yaw rate acceleration are modelled into the two-degree-of-freedom equation to solve the tire cornering stiffness in real time. This can ensure the accuracy of model.