bluuebunny/crossref_metadata_2025 huggingface dataset:
Estrategia metodológica innovadora para el mejoramiento de la lecto-escritura en los estudiantes de Cuarto Año Educación General Básica del CECIB Sergio Núñez
Authors: Chancusig Tuso Diego Armando , Flores Cuyachamin Alexandra Maribel , Suntasig Ronquillo Luis Fernando , Suntasig Calvopiña Wendy Judith
Published: August 2024

Introducción: La innovación en la lecto-escritura mejora el proceso del aprendizaje significativo en los estudiantes. Objetivo: Proponer una estrategia metodológica innovadora para el mejoramiento de la lecto-escritura en los estudiantes de Cuarto Año Educación General Básica (EGB). Metodología: La presente investigación se centra en el enfoque cuantitativo porque trabajamos con grupos humanos buscando el cambio y la transformación respondiendo al paradigma crítico- propositivo que posibilita la generación de aprendizajes constructivistas, además  se proyecta de manera cuantitativa porque corresponde a un estudio integrado que plantea una propuesta en torno a los procesos de lectura y escritura, focalizados en el fortalecimiento de estas habilidades comunicativas el mismo que ha requerido adaptaciones de tipo escolar, familiar y social. Resultados: 1. Se logra identificar los problemas de lecto-escritura en los estudiantes de Cuarto Año EGB. 2. Se aporta a fundamentar teóricamente el uso de una estrategia metodológica innovadora para el mejoramiento de la lecto-escritura.3. Se contribuye a diseñar una estrategia metodológica innovadora para el mejoramiento de la lecto-escritura en los estudiantes de 5to Año EGB. Conclusiones: La presente investigación es atractiva, confiable e innovadora.  Establece e identifica problemas de lecto escritura en los estudiantes, ya que al tratarse de una estrategia metodológica se basa en la teoría constructivista a través de la lectura y la escritura los estudiantes, los cuales serán capaces de construir su propio aprendizaje favoreciendo el rendimiento escolar de los estudiantes en la expresión oral y escrita, en tal virtud es importante el conocimiento y dominio de nuevas estrategias pedagógicas, ya que estas permiten desarrollar el interés y la motivación por el aprendizaje de nuevos conocimientos. Área de estudio general: Lengua y literatura. Área de estudio específica: Pedagogía de lengua y literatura. Tipo de artículo: artículo original.
Incidence of Polytrauma in the Casualty Emergency Department of a Tertiary Care Hospital in Dhaka City
Authors: Rahman AKM Mustafizur , Sharmin Farzana , Islam Mainul , Shoman Mohammed Mohiuddin
Published: August 2024

Background: Polytrauma is a public health problem in every country.
Objective: The purpose of the present study was to assess the incidence of Polytrauma in the Casualty Emergency Department of a tertiary care hospital in Dhaka city.
Methodology: This cross-sectional study was carried out in the casualty of Emergency Department of Dhaka Medical College Hospital, Dhaka, Bangladesh. The patients who were admitted from January 2014 to December 2014 were included in this study. This study includes all the patients with polytrauma, most of whom underwent laparotomy or other types of surgery like suprapubic cystostomy, amputation, surgical toileting, chest drainage, but a small number was managed with non-operative approach. Immediately after admission, the patients were subjected to resuscitation, primary survey and history taking including pre-hospital retrieval. A tabulated sheet of questionnaire was given to all the patients and answer was taken by conversation and examination.
Results: A total number of 100 patients were recruited for this study. The mean age with SD of the study population was 33.5±12.5 with the range of 3 to 67 years. The male female ratio is 7.33:1. The victims of polytrauma sustained their injury from different kinds of trauma. Out of hundred cases with polytrauma, road traffic accidents was the most common cause which included motor vehicle accident, pedestrian and motor cycle accident and resulted in a total of 63 casualty occupying 63% of the entire series. Polytrauma resulted fall from height occurred in 10 (10%) cases. Stab injury caused polytrauma in 5 (5%) cases.
Conclusion: In conclusion majority of the study population is young adult with the predominance of male presented with road traffic accident.
Journal of Current and Advance Medical Research, July 2023;10(2):60-64
Diabetes Mellitus: A Global Health Concern Rising in Bangladesh
Authors: Emdad Md Salahuddin
Published: August 2024

Abstract Not Available
Journal of Current and Advance Medical Research, July 2023;10(2):47-48
Fâdıl Sâlih es-Sâmerrâî’de Gramatiğin Mânaya Etkisinin İhtimâlî Anlamlar Üzerinden Okunması
Authors: Duran Gürbüz Sultan
Published: August 2024

Sarf ve nahiv disiplinleri, Arap dili gramerini oluşturan iki temel unsurdur. Burada özellikle nahvin görünürlüğü daha fazla olmakla beraber gramatik açıdan mânaya etki eden unsurların başında îrab gelmektedir. Îrab, dilbilimin üzerinde önemle durduğu bir disiplindir. Dilbilimde sadece anlam üzerine yapılan çalışmalarda dahi îrabın veya en genel anlamıyla gramatiğin fonksiyonu açıkça fark edilmektedir. Fâdıl Sâlih es-Sâmerrâî, dilbilim üzerine yaptığı çalışmalarında Arap gramerine anlam boyutunu da dahil etmiştir. Bu yönüyle onun yaptığı, bir nevî Abdülkâhir el-Cürcânî’nin üzerinde durduğu “meâni’n-nahv” yaklaşımını devam ettirmektir, denebilir. Sentaktik adlandırmaların mânaya getirmiş olduğu farklılıklar üzerinde duran Sâmerrâî, metnin okuruna veya muhatabına sunmuş olduğu belirsizliğin sebeplerini, dilin anlamsal ve mantıksal çıkarım yollarına başvurarak açıklamaktadır. Ona göre sözün dış dünyadaki karşılığının cümlenin ögeleri denilen küçük yapı birimlerinden etkilenmesi, söylenmek istenilen ifadeleri birtakım delâletlere sevk etmektedir. Söz konusu olan bu delâletler, Fâdıl Sâlih es-Sâmerrâî’de kat’î, ihtimâlî, zannî ve bâtınî gibi ayrımlara tabidir. Sâmerrâî’de kelime veya kelime gruplarının îrab denilen olgu sebebiyle okunuş şekillerindeki farklılıklar, anlam üzerinde olası yargılara sebep olabilmektedir. İfadeyi kat’î olmaktan çıkararak ihtimâlî anlamlara sevk eden bu unsurlar, Sâmerrâî’ye göre şunlardır: Müfret mânada bulunan lafız ortaklığı, sîgada bulunan ortaklık, sözün göstermiş olduğu mânanın tek veya mürekkeb bir kelimeden oluşması, kelimenin aslının veya vezninin açık olmaması, kelimenin îrab bakımından olası ihtimâllere yol açan sîgadan gelmesi, cümlede ister kayıt ister başka bir şey olsun mânada ihtimâle yol açan bir kelimenin zikredilmesi, cümlede yapılan hazif, îrabın mevkîsi, hakîkatin mi mecâzın mı murâd edildiği konusundaki ihtilâf, te’lîfinde birden çok mânayı taşıyan cümleler, ibârede durma yerleri. Bu makalede tüm bu etkenlerin anlam üzerinde ne tür ihtimâllere sebebiyet vereceği araştırma konusu edilmiştir.
Does Dual and/or Double Trigger Improve In Vitro Fertilisation Success?
Authors: Antoniou Victoria
Published: August 2024

DO THE risks of using dual or double trigger in vitro fertilisation (IVF) outweigh the benefits, or do the benefits outweigh the risks? This was the question posed to the audience by co-chairs Nikolaos Polyzos, Dexeus University Hospital, Barcelona, Spain, and Joop Laven, Erasmus Medical Center, Rotterdam, the Netherlands, at the very beginning of a fascinating debate session at the European Society of Human Reproduction and Embryology (ESHRE) 40th Annual Meeting, which took place from 7th–10th July 2024 in Amsterdam, the Netherlands. Though the audience members were initially hesitant to share their thoughts, this first poll demonstrated a strong preference for dual or double trigger as opposed to against. The ensuing talks aimed to convince the crowd one way or the other, as experts in the field joined Laven and Polyzos to debate.
Bibliometric Analysis of Healthcare Facility Promotion Strategies through Social Media in Indonesia: Systematic Literature Review
Authors: Lestari Saptandia Wulan Cahyaning , Ernawaty Ernawaty , Nur Aina Shofi Salsabila , Adyatma Rangga Gama
Published: August 2024

Recently most health facilities used social media as a medium for promoting their services and products. Thus, it was necessary to analyze the use of social media as a means of promoting health facilities to determine its effectiveness, novelty and relationship with other fields. This literature study attempted to analyze various research articles that discuss strategies for promoting health facilities through social media by bibliometric method. This was a systematic literature review which the data collection used Preferred Reporting Items Systematic Reviews and Meta-Analyses (PRISMA) method and the data was analyzed using bibliometric stages. The results of this research showed that the development of the use of social media continued to increase. Besides, the research also found that the interconnectedness of health facility promotion strategies was related to the promotion strategies of other businesses which also use social media as promotional media. Future researchers had opportunities to get novelties to conduct collaborative research with other scientific fields.
IMPLEMENTASI BUDAYA MEMBACA YAASIIN BERSAMA SEBELUM PEMBELAJARAN DI MADRASAH ALIYAH MAMBAUL ULUM COROGO JOMBANG
Authors: Fadhilah Alfin , Jumari
Published: August 2024

This article intends to describe how the implementation of the yaasiin reading culture before learning, knowing the planning of the yaasiin reading culture, knowing the implementation of the yaasiin reading culture, knowing the evaluation system for the yaasiin reading culture, and knowing the inhibiting factors and their solutions as well as the results of implementing the yaasiin reading culture before learning. This research includes qualitative research. There are two sources of data, namely primary data sources and secondary data sources. The data were obtained using observation, interview and documentation techniques. Data analysis was carried out with the method of compiling, connecting, reducing, presenting, then the data could be concluded. The results of this study revealed three findings, namely the implementation of the Yaasiin reading culture before learning at MA Mambaul Ulum Corogo including planning, implementing and evaluating the Yaasiin reading culture before learning. Implementation of the Culture of Reading Yaasiin Together Before Learning at Madrasah Aliyah Mambaul Ulum Corogo runs conducive, and istiqomah
IMPLEMENTASI METODE MEMBACA NYARING DAN MENDENGAR MUROTTAL AL- QUR`AN DALAM MENINGKATKAN HAFALAN SANTRI DI PONDOK PESANTREN NURUL AHMADI CATAK GAYAM MOJOWARNO JOMBANG
Authors: Nur Rofikul Maulidah
Published: August 2024

This article intends to discuss the implementation of the method of reading aloud and listening to the murottal Qur'an in increasing the memorization of students at Pondok Pesantren Nurul Ahmadi Catak Gayam Mojowarno Jombang. This research uses a qualitative method that aims to find out something in depth. This research is included in the case study by analyzing what was stated by Miles and Huberman. The data obtained are the results of observations, interviews and documentation which are then analyzed and concluded. The results of the study found that the planning method for reading aloud and listening to murattal al-Qur'an was when the teacher wanted to memorize the students' readings by the teacher and then students imitated so that they could be more thorough in reading, reading and makhoijul letters. supporting factors are mentoring, availability of tools, integration between institutions and pesantren, time management and a good system. While the inhibiting factor is the lack of students who have difficulty in applying recitation and makharijul letters when reading the Qur'an, the feeling of laziness and boredom felt by students.
INTERNALISASI NILAI ETIKA KITAB TAISIR AL-KHOLLAQ UNTUK MEMBENTUK KEPRIBADIAN SISWA DI MA AL-BAIRUNY SAMBONG DUKUH JOMBANG
Authors: Jannah Miftahul , Inayatul Ilahiyah Iva
Published: August 2024

Abstrak: Pendidikan merupakan kebutuhan yang harus dimiliki oleh setiap bangsa. Dengan pendidikan maka arah kehidupan akan tertata. Adapun salah satu pendidikan yang sangat penting adalah perihal etika. Seperti halnya di MA Al-Bairuny yang melaksanakan pembelajaran berbasis kitab yang membahas tentang etika dengan salah satu tujuan untuk membentuk kepribadian siswa-siswanya. Penelitian ini membahas tentang internalisasi nilai-nilai etika dalam kitab taisir Al-Khollaq, kepribadian siswa di MA Al-Bairuny Sambong Dukuh Jombang, serta pembentukan kepribadian siswa di MA Al-Bairuny Sambong Dukuh Jombang. Adapun penelitian ini menggunakan pendekatan kualitatif dengan jenis penelitian studi kasus. Data yang terkumpul dari observasi dan wawancara dianalisis menggunakan teknik pengecekan kebasahan data melalui metode triangulasi sumber. Hasil penelitian yang telah dilakukan menunjukkan bahwa internalisasi nilai-nilai etika dalam kitab Taisir Al-Khollaq di MA Al-Bairuny dilaksanakan melalui pembelajaran langsung dengan metode ceramah. Selain itu sekolah juga selalu melakukan briefing-briefing mengenai pendidikan etika pada siswa-siswanya. Dan juga usaha guru-guru dalam mendidik Kepribadian siswa di MA Al-Bairuny sangat bermacam-macam sebab mereka berasal dari latar belakang yang berbeda-beda. Tujuan internalisasi tersebut yaitu untuk membentuk kepribadian siswa, sebab tidak menutup kemungkinan bahwasanya kepribadian siswa di MA Al-Bairuny sudah baik dan sempurna semua. Hal demikian justru menjadi tanggung jawab pihak sekolah untuk dapat membentuk kepribadian siswa menjadi baik.
 
Kata Kunci: Internalisasi, Nilai Etika, Kitab Taisir Al-Khallaq, Kepribadian.
STRATEGI TAHFIDZUL QUR’AN MELALUI KAIDAH TURKI UTSMANI DI UICCI (UNITED ISLAMIC CULTURAL CENTER OF INDONESIA) SULAIMANIYAH KERTOSONO NGANJUK
Authors: Laili Alfi Zulfiatul , Masruroh Laily
Published: August 2024

The method is definitely needed in memorizing the Qur'an, the method itself is a tool to achieve success. There are lots of methods of memorizing the Al-Qur'an, namely memorizing the Al-Qur'an from chapters 1 to 30, basically what we encounter in many Islamic boarding schools uses the same method as the wahdah method, Talaqqi and many other methods. However, at UICCI (United Islamic Cultural Center Of Indonesia) Sulaimaniyah Kertosono Nganjuk is different from other methods which of course have the same goal, namely to instill faith and piety in the younger generation who memorize the Al-Qur'an. Therefore, the objectives of this study are: 1) To acquire knowledge of Al-Qur'an memorization strategies at UICCI (United Islamic Cultural Center Of Indonesia) Sulaimaniyah Kertosono Nganjuk. 2) Knowing the strategy of memorizing the Qur'an using the Ottoman Turkish method at UICCI (United Islamic Cultural Center Of Indonesia) Sulaimaniyah Kertosono Nganjuk. 3) Gaining knowledge about the factors that influence the memorization of the Qur'an with the Ottoman Turkish method. This study uses a qualitative method with an interactive type and information approach. From the results of the study it can be concluded that the strategy of using the Ottoman Turkish method is a round system and consists of 20 rounds, before memorizing students are also required to master the makharijul letters until they reach the desired criteria. Because of the uniqueness of this method, students feel bored because basically every day they will change chapters.
Bactoware: Bio crafting technique using MICP methods from ureolytic bacteria
Authors: Wang Crystal
Published: August 2024

This research project “Bactoware” harnesses bacterial biomineralization process which enables artisans to create with microorganisms. In contrast to the cold, synthetic urban environments we now inhabit, this project reinstates biologically made earthenware to bring warmth back into our everyday living. The research initialled with testing microbiologically induced calcite precipitation (MICP) protocol on different types of calcium-based materials sourced from waste stream, by utilising mesh fabrics and acrylic frames to design a novel scaffold-moulding technique for cast bio-craft. By making future crafting techniques with bacterium and biomineralization, Bactoware proposes a biotechnological approach to solve the caron dioxide emissions and energy consumption caused by kiln firing process. The findings of this study have significant implications for the development of sustainable and regenerative strategies as new ways of producing bacterial-made ceramics with improved mechanical properties for the making process in artisanry.
Comprehensive insights of pretreatment strategies on the structures and bioactivities variation of lignin-carbohydrate complexes
Authors: Su Chen , Wang Xiu , Deng Yongjun , Tian Zhongjian , Huang Chen , Fang Guigan
Published: August 2024

Introduction: Due to its unique structural features and bioactivities, the lignin-carbohydrate complex (LCC) displays great potential in vast industrial applications. However, the elucidation of how various pretreatment methods affect the structure and bioactivities remains unaddressed.

Method: The three pretreatment methods were systematically studied on the variations of structures and bioactivities, and the Gramineae plant, i.e., wheat straw, was adopted in this study. The structures and bioactivities variation caused by different pretreatments were studied in detail.

Result and Discussion: The results showed that compared to physical or chemical pretreatments, biological pretreatment was the most effective approach in improving the bioactivities of LCC. The LCC from biological pretreatment (enzymatic hydrolysis, ELCC4) had more functional groups while the lower weight-average molecular weight (Mw) and polydispersity index (PDI) were well-endowed. The highest antioxidant abilities against ABTS and DPPH of ELCC4 were high up to 95% and 84%, respectively. Furthermore, ELCC4 also showed the best ultraviolet (UV)-blocking rate of 96%, which was increased by 6% and 2% compared to LCC8 (physical pretreatment) and LLCC4 (chemical pretreatment). This work prospectively boosts the understanding of pretreatment strategies on the structures and bioactivities variation of LCC and facilitates its utilization as sustainable and biologically active materials in various fields.
The value of phenylalanine in predicting atrial fibrillation risk in chronic heart failure
Authors: Zhou Qing-Fen , Lu Qiu-Ya , Dai Yang , Chen Qiu-Jing , He Xiao-Shuang , Chen Shuai , Zhao Jun-Tao , Zhang Feng-Ru , Lu Lin , Yang Fan
Published: August 2024

Backgrounds

Atrial fibrillation (AF) is a common complication of chronic heart failure (HF). Serum phenylalanine (Phe) levels are related to inflammation disorder. It is meaningful to study the circulating Phe with AF occurrence in HF.

Methods

The cross-sectional study recruited 300 patients (78.0% male; mean age, 65 ± 13 years) with HF (left ventricular ejection fraction of ≤50%, containing 70 AF patients) and 100 normal controls. Serum Phe value was measured by liquid chromatography–tandem mass spectrometry. Logistic regression analysis was conducted to measure the association between Phe and AF risk in HF. The association between Phe and high-sensitivity C-reactive protein (hsCRP) was assessed by simple correlation analysis. In the prospective study, the 274 HF subjects (76.6% male; mean age, 65 ± 13 years) were followed up for a mean year (10.99 ± 3.00 months).

Results

Serum Phe levels increased across the control, the HF without AF, and the HF with AF groups (77.60 ± 8.67 umol/L vs. 95.24 ± 28.58 umol/L vs. 102.90 ± 30.43 umol/L, ANOVA P < 0.001). Serum Phe value was the independent risk factor for predicting AF in HF [odds ratio (OR), 1.640; 95% CI: 1.150–2.339; P = 0.006]. Phe levels were correlated positively with hsCRP value in HF patients with AF (r = 0.577, P < 0.001). The elevated Phe levels were associated with a higher risk of HF endpoint events in HF patients with AF (log-rank P = 0.005).

Conclusions

In HF with AF subjects, elevated Phe value confers an increased risk for prediction AF and was more related to poor HF endpoint events. Phe can be a valuable index of AF in HF.
Blunted cardiac autonomic dynamics to active standing test in postmenopausal women
Authors: Scatà Costanza , Ferreira Felipe C. , Padilha Michelle C. S. V. , Carandina Angelica , Asnaghi Riccardo , Bellocchi Chiara , Tobaldini Eleonora , Montano Nicola , Soares Pedro Paulo da S. , Rodrigues Gabriel D.
Published: August 2024

Introduction

Although both aging and menopause influence cardiovascular autonomic control, the effect of menopause per se remains unclear. The current study was undertaken to test the hypothesis that post-menopausal women (PMW) have a blunted cardiovascular autonomic adjustment to active standing compared to pre-menopausal women. Thus, we compared the heart rate variability (HRV) indexes from supine (SUP) to orthostatic (ORT) positions among young women (YW), young men (YM), older men (OM), and PMW.

Methods

The participants rested for 10 min in SUP and then stood up and remained for 5 min in ORT. ECG was continuously recorded, and R-R time series of about 300 beats were analyzed using linear (spectral analysis) and non-linear (symbolic analysis) methods. The variation from SUP to ORT was calculated (Δ = ORT-SUP) for each HRV index.

Results

In SUP, no difference was found for any HRV index among groups. However, Δ0V% and ΔLFn (cardiac sympathetic modulation) were reduced in PWM compared to all groups (OM, YW, and YM), while Δ2UV% and ΔHFn (cardiac vagal modulation) were reduced in PMW than the younger group (YW and YM). No differences were found among the male groups (OM and YM).

Discussion

In light of our results, the cardiac autonomic dynamic response to orthostatic stress is blunted in post-menopausal women compared to younger women and older men, a finding that might be influenced not only by aging.
Evaluation of preprocedural statin loading on clinical outcomes in patients undergoing elective percutaneous coronary intervention
Authors: Sinan Umit Yasar , Keskin Meric Bengisu , Bursa Nurbanu , Moumin Gkiozde , Kaya Aysem , Arat Ozkan Alev
Published: August 2024

Background and aim

High-dose statin therapy before percutaneous coronary intervention (PCI) is thought to reduce the occurrence of Peri-procedural Myocardial Infarction (PPMI), which is associated with increased mortality and prolonged hospitalization, especially in statin naïve patients. This study aims to investigate the effect of rosuvastatin loading dose on PPMI and major adverse cardiac and cerebrovascular events (MACCE) in patients undergoing elective PCI, considering their statin use.

Methods

One hundred sixty-five patients with stable coronary artery disease (CAD) without heart failure (HF) or chronic kidney disease (CKD) were included in the study. They were divided into two groups: patients already on statin treatment (n:126) and statin naive patients (n:39). Both groups were randomly assigned to high-dose (40 mg) rosuvastatin (n:86) or a non- loading dose group (n:79). The primary endpoint was the incidence of PPMI, and the secondary endpoint was MACCE.

Results

The mean age of study population was 59 ± 9.4 years with 77% being male (n = 127). The median follow-up (FU) time was 368 day. Thirty patients were diagnosed with PPMI after PCI (19 in the high-dose group and 11 in the no-loading-dose group). Meanwhile, less than half of study population (77 patients, 46.7%) had complex lesion type (B2, C) and 88 of those (53.3%) had simple lesion type (A, B1). PPMI was observed more frequently in statin-naive patients (23%) than in statin users (17%), although the difference was not statistically significant. Only two patients (1.2%) experienced MACCE during the FU period. One of these patients, who had a type C lesion, belonged to group A2 and underwent Target Vessel Revascularization (TVR) on the 391st day. The other patient, with a type B1 lesion, was in group A1 and was hospitalized due to Acute Coronary Syndrome (ACS) on the 40th day of FU.

Conclusions

Pre-procedural administration of high dose rosuvastatin in patients with stable coronary artery disease did not decrease PPMI, independent of chronic statin use.
A study of the relationship between social support, depression, alexithymia and glycemic control in patients with type 2 diabetes mellitus: a structural equation modeling approach
Authors: Gan Yuqin , Tian Fengxiang , Fan Xinxin , Wang Hui , Zhou Jian , Yang Naihui , Qi Hong
Published: August 2024

Aim

The aim of this research was to ascertain the correlations between alexithymia, social support, depression, and glycemic control in patients diagnosed with type 2 diabetes mellitus. Additionally, this study sought to delve into the potential mediating effects of social support and depression in the relationship between alexithymia and glycemic control.

Method

A purposive sampling methodology was employed to select a cohort of 318 patients afflicted with type 2 diabetes mellitus, hailing from a care establishment situated in Chengdu City. This investigation embraced a cross-sectional framework, wherein instruments such as the General Information Questionnaire, the Toronto Alexithymia Scale 20, the Social Support Rating Scale, and the Hamilton Depression Scale were judiciously administered. The primary objective of this endeavor was to unravel the interplay that exists amongst alexithymia, social support, depression, and glycemic control. The inquiry discerned these interrelationships through both univariate and correlational analyses, subsequently delving into a comprehensive exploration of the mediating ramifications engendered by social support and depression in the nexus between alexithymia and glycemic control.

Results

The HbA1c level of patients diagnosed with type 2 diabetes mellitus was recorded as (8.85 ± 2.107), and their current status with regards to alexithymia, social support, and depression were measured as (58.05 ± 4.382), (34.29 ± 4.420), and (7.17 ± 3.367), respectively. Significant correlations were found between HbA1c and alexithymia (R=0.392, P<0.01), social support (R=-0.338, P<0.01), and depression (R=0.509, P<0.01). Moreover, alexithymia correlation with social support (R=-0.357, P<0.01) and with depression (R=0.345, P<0.01). Regarding the mediation analysis, the direct effect of alexithymia on HbA1c was calculated to be 0.158, while the indirect effect through social support and depression were 0.086 and 0.149, respectively. The total effect value was determined to be 0.382, with the mediating effect accounting for 59.95%, and the direct effect accounting for 40.31%.

Conclusion

Alexithymia exerts both direct and indirect adverse effects on glycemic control, thereby exacerbating disease outcomes. Hence, it is imperative to prioritize the mental health status of individuals with type 2 diabetes to enhance overall well-being, ameliorate diabetes-related outcomes, elevate patients’ quality of life, and alleviate the psychological distress and financial burden associated with the condition.
Prevention and management of hypertensive crises in children with pheochromocytoma and paraganglioma
Authors: Bima Chiara , Lopez Chiara , Tuli Gerdi , Munarin Jessica , Arata Stefano , Procopio Matteo , Bollati Martina , Maccario Mauro , De Sanctis Luisa , Parasiliti-Caprino Mirko
Published: August 2024

Hypertensive crises in pediatric patients are rare conditions. However, determining their precise prevalence is more challenging than in adults due to the heterogeneity in the definition itself. These crises frequently occur without a prior diagnosis of hypertension and may indicate an underlying cause of secondary hypertension, including pheochromocytoma/paraganglioma (PPGL). The mechanisms of hypertensive crises in the pediatric population with PPGL are directly related to different types of catecholamine excess. Noradrenergic tumors typically present with sustained hypertension due to their predominant action on α1-adrenoceptors in the vasculature. Conversely, adrenergic tumors, through epinephrine binding to β2-adrenoceptors in addition to stimulation of α1- and α2-adrenoceptors, more frequently cause paroxysmal hypertension. Furthermore, the biochemical phenotype also reflects the tumor localization and the presence of a genetic mutation. Recent evidence suggests that more than 80% of PPGL in pediatric cases have a hereditary background. PPGL susceptibility mutations are categorized into three clusters; mutations in cluster 1 are more frequently associated with a noradrenergic phenotype, whereas those in cluster 2 are associated with an adrenergic phenotype. Consequently, the treatment of hypertensive crises in pediatric patients with PPGL, reflecting the underlying pathophysiology, requires first-line therapy with alpha-blockers, potentially in combination with beta-blockers only in the case of tachyarrhythmia after adequate alpha-blockade. The route of administration for treatment depends on the context, such as intraoperative or pre-surgical settings, and whether it presents as a hypertensive emergency (elevated blood pressure with acute target organ damage), where intravenous administration of antihypertensive drugs is mandatory. Conversely, in cases of hypertensive urgency, if children can tolerate oral therapy, intravenous administration may initially be avoided. However, managing these cases is complex and requires careful consideration of the selection and timing of therapy administration, particularly in pediatric patients. Therefore, facing these conditions in tertiary care centers through interdisciplinary collaboration is advisable to optimize therapeutic outcomes.
Parameter identification method of load modeling based on improved dung beetle optimizer algorithm
Authors: Xing Chao , Xi Xinze , He Xin , Deng Can
Published: August 2024

The role of load modeling in power systems is crucial for both operational and regulatory considerations. It is essential to develop an effective and reliable method for optimizing load modeling parameter identification. In this paper, the dung beetle algorithm is improved by using the good point set, and a load model parameter identification strategy based on the good point set dung beetle optimization algorithm (GDBO) within the framework of the measurement-based load modeling method. The proposed parameter identification strategy involves utilizing PMU voltage data as input, selecting a comprehensive load model, and refining the initialization process based on the good point set to mitigate the influence of local maxima. Through iterative optimization of the objective function using the Dung Beetle Optimizer (DBO) algorithm, the optimal parameters for the comprehensive load model are determined, enhancing the model’s ability to accurately capture the power curve. Analysis of examples pertaining to PMU-measured modeling parameter identification reveals that the proposed GDBO algorithm, which incorporates a good point set, outperforms alternative methods such as the improved differential evolution algorithm (IDE), particle swarm optimization algorithm (PSO), grey wolf optimization algorithm (GWO), and conventional DBO algorithm. This demonstrates the superior performance of the introduced approach in the context of load model parameter identification.
Security-constrained unit commitment model considering frequency and voltage stabilities with multiresource participation
Authors: Zidong Zhou , Jinquan Zhao
Published: August 2024

The rapidly increasing proportion of renewable energy sources has led to a reduction in the relative share of synchronous units, which has resulted in a decline in the inertia of the power system and a decrease in its voltage support capacity. This has led to several issues related to the frequency and voltage stabilities of the power system. To ensure these frequency and voltage stabilities, it is necessary to maintain a number of synchronous units online in the day-ahead generation schedule. First, the dynamic frequency change process after a power system fault is discussed, and a linear expression is derived for the frequency stability constraints involving energy storage systems and wind turbines. Second, the short-circuit capacity of the bus is characterized to describe the strength of voltage support, and the minimum short-circuit capacity requirement of the bus is solved based on the transient voltage recovery problem after clearance of the short-circuit faults. The total short-circuit capacity provided by the unit to the bus is then calculated through the network reactance matrix to establish the voltage stability constraint. Subsequently, the security-constrained unit commitment model considering frequency and voltage stabilities (FVS-SCUC) is established. Finally, the effectiveness of the proposed model is demonstrated through a numerical simulation of the IEEE-39 system comprising storage and wind turbines. The model ensures the frequency and voltage securities of the system, and the renewable energy output is improved upon considering energy storage. Thus, the overall system cost was reduced by nearly 30% by considering the frequency regulation effects of the energy storage system and wind turbine as well as the voltage regulation effects of the energy storage system.
Exploring the relationship between vulnerability and adaptation of rural households: disaster resettlement experience from rural China
Authors: Liu Wei , Duan Mingfei , Feldman Marcus
Published: August 2024

In the face of environmental deterioration and to improve human welfare, China’s Shaanxi provincial government has launched one of the largest disaster shelter and resettlement projects in history. In assessing the likely success of this project, it is important to measure the vulnerability and adaptation of rural households in areas where the population experiences ecological and livelihood vulnerability. Based on 657 rural questionnaires collected in southern Shaanxi relocation zones, this study explores four categories of relationship between vulnerability and adaptation based on two aspects of livelihood resilience, namely specific resilience and general resilience. A multinomial logistic regression model is employed to investigate the influence of disaster resettlement on these categories. The analysis finds that: (1) there is a connection between these categories and household livelihood strategies, and rural households are more likely to adopt non-agricultural strategy or livelihood diversification strategy; (2) the livelihood resilience of relocated households is significantly higher than that of non-relocated household, with specific resilience being the main reason for the difference; (3) participation in disaster resettlement, centralized resettlement, and high relocation subsidies are not conducive to belonging in the “low vulnerability–high adaptation” category, while voluntary relocation is conducive to being in this category. These results have significant ramifications for China and other developing national disaster resettlement programs. It is critical for resettled households to reduce livelihood vulnerability and improve adaptive capacity.
Sociality modulates nutritional carrying capacity of an endangered species
Authors: Rankins Seth T. , Stephenson Thomas R. , Monteith Kevin L.
Published: August 2024

Group living has well-known costs and benefits. Large groups may experience greater competition for resources, while simultaneously benefit from reduced risk through predator dilution. When there is a tradeoff between forage acquisition and predation risk, the ability to congregate into large groups may unlock access to previously unavailable habitat with high risk of predation, thereby increasing forage available to the population. We evaluated whether forage availability increased with population size and how it was mediated through changes in group size. There was a tradeoff between forage availability and predation risk. Larger groups used areas with more forage biomass and greater predation risk than smaller groups. Group size also increased with population abundance, meaning bighorn sheep used gentler terrain and areas with more forage biomass at greater population abundance. Group size functionally increased carrying capacity by yielding access to more resources for growing populations of gregarious ungulates.
Assessment of the hormesis effect and toxic damage of short-term low-dose aflatoxin B1 in grass carp (Ctenopharyngodon idellus)
Authors: Li Jin-long , Guo Jia-rong , Wang Pei , Zhang Jun-zhi , He Zhi-gang , Wang Jin-long , Hu Yi
Published: August 2024

The present study was conducted to evaluate the hormesis and toxicity of short-term low-dose aflatoxin B1 in grass carp (Ctenopharyngodon idellus). Triplicate isonitrogenous and isocaloric aflatoxin B1 diets—CD (control, 0 ug/kg), D1 (20 ug/kg), and D2 (500 ug/kg)—were prepared and fed to grass carp with an initial mean body weight of (15.2 ± 0.1) g for 56 days. The results showed that the weight gain rate and specific growth rate of grass carp fed diet D2 were significantly higher, and the feed coefficient and crude fat content of the whole body were significantly lower (P < 0.05) compared with those fed diet CD. Serum superoxide dismutase content of grass carp fed D1 diet increased significantly (P < 0.05) with an increasing dose of aflatoxin B1, but when the dose reached 500 ug/kg (D2), serum superoxide dismutase, complement C3, and immunoglobulin M of grass carp decreased significantly (P < 0.05), while malondialdehyde increased significantly (P < 0.05). After short-term feeding of aflatoxin B1-containing diets (D1 and D2), liver body index, visceral body index, serum total cholesterol, triglyceride, and urea nitrogen content of grass carp increased significantly (P < 0.05), total bile acid secretion decreased significantly (P < 0.05), and structural damages such as increase in vacuoles, organizational structure loosening, and nucleus translocation were observed in the liver. Meanwhile, liver function indexes such as serum alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase increased significantly with the increase of aflatoxin B1 dose (P < 0.05). In addition, the height of intestinal villi, crypt depth, villus–crypt ratio, and tubular cell number, as well as the content of trypsin and lipase activities in the intestine of grass carp in the D2 group, were significantly higher than those in the CD group (P < 0.05). In conclusion, after a short-term intake of low doses of aflatoxin B1 (≤500 ug/kg), the toxicological damage of aflatoxin B1 was pronounced, although it produced a certain degree of hormesis on the growth performance and intestinal structure and function of grass carp. At a dose of 20 ug/kg, the non-specific immune system and liver structure and function of grass carp showed obvious toxic damage.
Autoimmune thyroid disease modifies the clinical expression of hand osteoarthritis in older people: a third National Health and nutrition examination survey study
Authors: Tagoe Clement E. , Wang Wanyi , Kwon Helena H.
Published: August 2024

Introduction

The risk factors linked to hand osteoarthritis (OA) that contribute to its distinct symptoms and clinical presentation are not thoroughly understood. This study aimed to examine whether the autoimmune thyroid disease (AITD) autoantibodies, anti-thyroid peroxidase antibody (TPOAb), and anti-thyroglobulin antibody (TgAb), associate with hand OA and symptomatic hand OA in the Third National Health and Nutrition Examination Survey (NHANES III).

Materials and methods

We included 2,429 persons from NHANES III ≥60 years of age. Data on hand OA or symptomatic hand OA were examined with respect to their associations with TPOAb and TgAb. Log-binomial and modified Poisson regression models were fit to examine the associations between the anti-thyroid autoantibodies and hand OA or symptomatic hand OA.

Results

Higher levels of TPOAb were associated with a higher prevalence of symptomatic hand OA in the unadjusted (PR = 1.182, p = 0.024) and adjusted models after controlling for age, gender, and diabetes (PR = 1.174, p = 0.039). This association was no longer significant when positive TPOAb was considered a categorical variable with four levels and compared with negative TPOAb. TgAb showed a trend toward being positively associated with symptomatic hand OA (p < 0.10). When positive TgAb was considered a categorical variable with four levels and compared with negative TgAb, the highest quartile was associated with a higher prevalence of symptomatic hand OA than negative TgAb in the unadjusted (PR = 2.242, p = 0.008) and adjusted models (PR = 2.045, p = 0.038). There was no significant association between TPOAb or TgAb and hand OA.

Conclusion

Higher levels of TPOAb may be associated with the presence of symptomatic hand OA in persons ≥60 years old. Persons ≥60 years old with the highest quartile levels of TgAb may be more likely to present with symptomatic hand OA.
Modulations in gastrointestinal microbiota during postpartum period fulfill energy requirements and maintain health of lactating Tibetan cattle
Authors: Liu Jing , Ahmad Anum Ali , Yang Chen , Zhang Jianbo , Zheng Juanshan , Liang Zeyi , Wang Fang , Zhai Huan , Qin Shuanghong , Yang Feng , Ding Xuezhi
Published: August 2024

Introduction

Postpartum period of dairy cattle is an important phase of their life mainly associated with the changes in physiology, rumen function, and energy metabolism. Studies have shown that gut microbial composition undergoes drastic changes during the postpartum period. However, little is known about the temporal variations in digestive tract microbiota in postpartum Tibetan cattle. The aim of this study was to investigate the temporal variations in blood metabolites, ruminal fermentation, and microbial community of oral, rumen, and gut in lactating Tibetan cattle during postpartum.

Methods

We collected blood, saliva, rumen fluid, and fecal samples from lactating Tibetan cattle during 1st week (1 W), the 2nd week (2 W), the 1st month (1 M), and the 2nd month (2 M) of the postpartum period. The microbiota of saliva, rumen fluid, and fecal samples were assessed using 16S rRNA sequencing. The rumen volatile fatty acid and blood parameters were also quantified.

Results

The content of volatile fatty acids (VFAs) and blood parameters showed opposite tendency to each other and reached to stability at 2 M. Rumen microbiota showed the highest alpha diversity compared to other two sites. At phylum level, the oral cavity was dominated by Proteobacteria, while most dominant phylum in rumen and feces were Firmicutes and Bacteroidetes, respectively. The dominant genera in oral cavity were Moraxella and Bibersteinia, while genera Prevotella 1 and Ruminococcaceae UCG-005 were dominant in rumen and fecal samples, respectively.

Discussion

Microbial network analysis revealed that most of the active genera in all networks belonged to phylum Firmicutes, indicating the importance of this phyla during postpartum period of lactating cattle. The functional analysis revealed distinct division of labor among three gastrointestinal sites associated with defense, fatty acid synthesis, and maintaining health of host. All in all, our findings provide insights into the metabolic and microbial changes of lactating Tibetan cattle and help to the improvement of the management strategies.
Potential effectiveness of parenteral nemonoxacin in the treatment of Clostridioides difficile infections: in vitro, ex vivo, and mouse studies
Authors: Lee Ching-Chi , Yan Xiang-Zhe , Wu Hung-Tsung , Ko Wen-Chien , Tsai Pei-Jane , Hung Yuan-Pin
Published: August 2024

Introduction

Antimicrobial therapy plays a crucial role in the management of CDI patients. However, the standard agent for treating CDIs is limited to oral fidaxomicin or vancomycin. For patients made nil by mouth, there is a clinically urgent and essential need to develop an intravenous antibiotic.

Methods

For C. difficile with the lowest MIC of nemonoxacin and vancomycin, the inhibitory effects were tested using the kinetic time-kill assay and ex vivo co-culture model. The effectiveness of nemonoxacin and vancomycin in inhibiting spore germination, the sporicidal activity, and the treatment of mice with CDIs were compared.

Results

For clinical isolates and laboratory strains, lower MICs of nemonoxacin against C. difficile than levofloxacin and ciprofloxacin were observed, even in those harboring point mutations in the quinolone-resistance determining region. Although nemonoxacin failed to suppress spore outgrowth and germination in C. difficile, it exhibited an effective inhibitory effect against C. difficile in the kinetic time-kill assay and the ex vivo co-culture model. Mice receiving intraperitoneal nemonoxacin had less weight loss, higher cecum weight, a longer colon length, and lower expression of the tcdB gene, compared with untreated mice. Notably, there were no significant differences observed in weight loss, cecum weight, colon length, or tcdB gene expression between mice treated with vancomycin and those treated with any dose of nemonoxacin. Similarly, no significant differences were found between mice receiving combination therapy of intraperitoneal nemonoxacin plus oral vancomycin and those treated with intraperitoneal nemonoxacin or oral vancomycin alone.

Discussion

The potential role of nemonoxacin, which can be administered parenterally, for treating CDIs was evidenced through the in vitro, ex vivo, and mouse models.
Oral microbiota and metabolites: key players in oral health and disorder, and microbiota-based therapies
Authors: Bostanghadiri Narjess , Kouhzad Mobina , Taki Elahe , Elahi Zahra , Khoshbayan Amin , Navidifar Tahereh , Darban-Sarokhalil Davood
Published: August 2024

The review aimed to investigate the diversity of oral microbiota and its influencing factors, as well as the association of oral microbiota with oral health and the possible effects of dysbiosis and oral disorder. The oral cavity harbors a substantial microbial burden, which is particularly notable compared to other organs within the human body. In usual situations, the microbiota exists in a state of equilibrium; however, when this balance is disturbed, a multitude of complications arise. Dental caries, a prevalent issue in the oral cavity, is primarily caused by the colonization and activity of bacteria, particularly streptococci. Furthermore, this environment also houses other pathogenic bacteria that are associated with the onset of gingival, periapical, and periodontal diseases, as well as oral cancer. Various strategies have been employed to prevent, control, and treat these disorders. Recently, techniques utilizing microbiota, like probiotics, microbiota transplantation, and the replacement of oral pathogens, have caught the eye. This extensive examination seeks to offer a general view of the oral microbiota and their metabolites concerning oral health and disease, and also the resilience of the microbiota, and the techniques used for the prevention, control, and treatment of disorders in this specific area.