bluuebunny/crossref_metadata_2025 huggingface dataset:
Growth, Gas Exchange, and Boron Distribution Characteristics in Two Grape Species Plants under Boron Deficiency Condition
Authors: Wei Rong , Huang Mei , Huang Dong , Zhou Jinzhong , Pan Xuejun , Zhang Wen’e
Published: April 2022

The boron (B) deficiency tolerance capacity of two grape materials, ‘Xishui-4’ (Vitis flexuosa) and ‘Crystal’ (V. vinifera × V. labrusca), were evaluated using a potted experiment in order to identify the B-use efficiency of grape and screen B-efficient grape resources. The sterile lines of two genotypes of grape were used as test materials, and a large number of test-tube seedlings were obtained through rapid propagation. The test-tube seedlings were acclimatization and transplanted, and the tested seedlings were treated with B stress after survival. In this experiment, the materials were cultured in nutrient solution, which contained 0.00 (B0), 0.25 (B1), and 0.50 (control) mg·L−1 B concentrations, and the two genotypes of grape seedlings were cultured in vitro. The results were counted after 60 days of culture. The results showed that the B deficiency significantly reduced the growth parameters such as plant height, leaf area, total root length, and dry biomass of the two genotypes, and the inhibition of ‘Crystal’ growth parameters was greater than that of ‘Xishui-4’. Moreover, the B deficiency also affected photosynthesis of the two genotypes, such as decreased leaf photosynthetic pigments, net photosynthesis rate, transpiration rate, stomatal conductance, intercellular carbon dioxide concentration, and stomatal density. Interestingly, the decrease ranges of ‘Crystal’ were greater than those of ‘Xishui-4’, indicating that ‘Crystal’ photosynthesis was more susceptible to B deficiency. Under the control condition, the concentration and accumulation of B in ‘Crystal’ were significantly higher than those in ‘Xishui-4’. However, under the condition of B deficiency, the B concentration, accumulation amount, accumulation rate, utilization index, and tolerance index of ‘Xishui-4’ were higher than those of ‘Crystal’, and the B transport capacity of ‘Xishui-4’ was more stable, indicating that ‘Xishui-4’ had a better tolerance against B-deficient stress than ‘Crystal’ did. Therefore, ‘Xishui-4’ is a plant with strong adaptability to B deficiency stress, which can be used as B efficient grape resources and a genetic improvement of B efficient grape.
Determination of Recharge Areas That Supply Decades Old Groundwater to Creeks Inhabited by the Threatened Okaloosa Darter
Authors: Landmeyer James E. , McBride W. Scott , Tate William B.
Published: April 2022

The Okaloosa darter (Etheostoma okaloosae) is a diminutive, perch-like, benthic fish that inhabits only six small, clear, and shallow creek systems that flow almost entirely within Eglin Air Force Base in the panhandle of northwest Florida. Listed as Endangered by the U.S. Fish and Wildlife Service (USFWS) in 1973, improvements in erosion control and habitat restoration led to the Okaloosa darter being downlisted from Endangered to Threatened in 2011. However, the long-term management of the species is hampered by the lack of knowledge of the spatial extent of the recharge areas that ultimately support creek flow through groundwater discharge. To address this lack of data, we collected groundwater samples from the sand and gravel aquifer beneath 11 headwater and 11 downgradient sites across six creek basins during February and December 2020. The groundwater samples were collected from 1 to 1.2 m beneath the creek bottom. Concentrations of sulfur hexafluoride (SF6) were analyzed and used to calculate groundwater age (residence time), and indicated that at the 11 headwater sites, recharge occurred between 11 and 28 years ago. Groundwater ages in downgradient parts of the same creeks indicated that recharge occurred between 5 and 25 years ago. When combined with representative values of hydraulic conductivity for the sand and gravel aquifer, the ages reveal that the extent of the maximum recharge distance from the sampling sites ranged from about 222 to 2011 m from the creeks. This new information can be used by natural resource managers as additional evidence to support the USFWS Recovery Plan and proposed delisting of the Okaloosa darter from the Endangered Species List. Moreover, these results may also be useful to fisheries biologists to incorporate groundwater inputs to facilitate fisheries management.
Medication Adherence in Chronic Older Patients: An Italian Observational Study Using Medication Adherence Report Scale (MARS-5I)
Authors: Liquori Gloria , De Leo Aurora , Di Simone Emanuele , Dionisi Sara , Giannetta Noemi , Ganci Elvira , Trainito Sherly Pia , Orsi Giovanni Battista , Di Muzio Marco , Napoli Christian
Published: April 2022

Background: the world population is aging, and the prevalence of chronic diseases is increasing. Chronic diseases affect the quality of life of patients and contribute toward increased healthcare costs if patients do not adhere to treatment. This study defines the medication adherence levels of patients with chronic diseases. Methods: an observational cross-sectional study was carried out. Patients aged 65 years and older with chronic diseases were included in this study. The medication adherence report scale was used. Results: overall, 98 patients aged 65 years and older were included. The mean age of responders was 78.65 years. Study population: 71.43% were always adherent; 9.79% often adherent; 14.89% sometimes adherent; 3.87% rarely adherent; and 1% never adherent. The internal consistency of the MARS-5I was good: Cronbach’s alfa value of 0.77. Conclusions: the MARS-5I is an effective self-report instrument to measure the medication adherence of patients. However, further studies are needed to explore factors affecting medication adherence to avoid clinical consequences for patients and high healthcare costs for healthcare facilities. Healthcare communication could be improved to ensure better transitional care.
Lower-Limb Range of Motion Predicts Sagittal Spinal Misalignments in Children: A Case-Control Study
Authors: Cejudo Antonio
Published: April 2022

The main objective of this study was to determine lower-limb range of motion (ROM) as a risk factor associated with sagittal spinal misalignments in children. Two hundred and one children (10.9 ± 0.7 years old) from five different primary schools were recruited for this retrospective case—control study. Anthropometric variables, sagittal spinal alignment in habitual everyday postures, and lower-limb ROM, such as ankle dorsiflexion with the knee flexed (ADF-KF), hip extension with the knee relaxed (HE), and hip flexion with the knee extended (HF-KE) were measured. Multivariate and univariate analyses revealed differences between the means of HE and HF-KE ROM, and the thoracic and lumbar curves (p ≤ 0.034; η2 ≥ 0.052). The HE (p ≤ 0.028; OR ≥ 1.066) predicted sagittal thoracic misalignment in the slump sitting (SSP) and relaxed standing (RSP) postures in males and the sagittal lumbar misalignment in the RSP in female children; while HF-KE (p ≤ 0.006; OR ≥ 1.089) predicted sagittal thoracic misalignment in the maximum trunk forward flexion posture (MTFP) and sagittal lumbar misalignment in SSP and MTFP in males. In this study, the reference values for restricted HE and HF-KE were significantly associated with sagittal spinal misalignment in male children but not for the ankle ROM. Physical education teachers should include stretching exercises in the ISQUIOS programme to increase the extensibility of the iliopsoas (HE) and hamstrings (HF-KE) and prevent sagittal spinal misalignments in habitual everyday postures.
Effects of Olfactory Stimulation with Aroma Oils on Psychophysiological Responses of Female Adults
Authors: Choi Na-Yoon , Wu Yu-Tong , Park Sin-Ae
Published: April 2022

This study investigated the effects of olfactory stimulation with aroma oils on the psychophysiological responses in women. Ten aromatic oils (lavender, rosemary, rose, eucalyptus, jasmine, geranium, chamomile, clary sage, thyme, and peppermint) were used on 23 women aged between 20 and 60 years. They inhaled the scent for 90 s through a glass funnel attached to their lab apron, 10 cm below their nose, while the pump was activated. Electroencephalography, blood pressure, and pulse rate were measured before and during inhalation of the aroma oils. The relative alpha (RA) power spectrums indicating relaxation and resting state of the brain significantly increased when lavender, rosemary, eucalyptus, jasmine, chamomile, clary sage, and thyme oils were inhaled compared to those of before olfactory stimulation. The ratio of alpha to high beta (RAHB), an indicator of brain stability and relaxation, significantly increased when rosemary, jasmine, clary sage, and peppermint oils were inhaled. The relative low beta (RLB) power spectrum, an indicator of brain activity in the absence of stress, significantly increased when stimulated with lavender, rosemary, rose, and geranium scents. Further, systolic blood pressure significantly decreased after introduction of all 10 types of aromatic oils, which indicates stress reduction. Thus, olfactory stimulation with aroma oil had a stabilizing effect on the prefrontal cortex and brain activity and decreased systolic blood pressure.
Effectiveness Analysis for Smart Construction Safety Technology (SCST) by Test Bed Operation on Small- and Medium-Sized Construction Sites
Authors: Kim Yong-Seon , Lee Jae Yun , Yoon Young-Geun , Oh Tae-Keun
Published: April 2022

In the global construction industry, government policies have recently focused on smart construction technologies, such as those concerning the “smartization” of construction, improvements of productivity, and automation technologies. In addition, smart construction safety technologies (SCSTs) have been developed to ensure workers’ safety, under the initiative of the private sector. In regards to overseas occupational safety, wearable technologies have been developed for various types of industries, and the integrated platform developments needed to link them have become mainstream. In South Korea, individual companies are focusing on developing basic SCSTs and platforms for integrated control, aiming to prevent accidents in the construction field. The goal of this study was to identify the pros and cons of SCSTs through test bed operation and to derive improvement directions. Therefore, a test bed embedded with SCSTs was built and operated to provide effective safety management for small- and medium-sized sites exposed to fatal accidents. From analyzing the data from the test bed, it was found that it is difficult to change the tendencies of workers’ behaviors based solely on the introduction of SCSTs. This indicates that the effects of SCSTs are insignificant without the cooperation of workers. In addition, technical problems in field application were identified for each sensor and equipment, and the necessity, problems, and effectiveness of SCSTs were analyzed. As a result, both the installation and attachment types were found to be effective; however, workers avoided wearing certain attachment types. Based on the results derived through analysis of the pros and cons of SCSTs, the directions and guidelines were suggested for future use. This result can be used for future technology development directions, and policy establishment. Additionally, for the activation of SCSTs in the field, the cooperation of workers and the interest of managers remain essential factors, and improvements to the equipment are required.
Framing Climate Change Impacts as Moral Violations: The Pathway of Perceived Message Credibility
Authors: Huang Jialing , Yang Janet Z. , Chu Haoran
Published: April 2022

Climate change has been increasingly discussed in moral terms in public discourse. Despite the growing body of research on the effectiveness of moral frames in bridging the ideological divide, few studies have examined the role that perceived credibility, an important element of any persuasive appeal, plays in facilitating the framing effect. With the objective of further understanding how moral frames may engage individuals with different ideologies in climate change and refining climate change messaging strategies, two experimental surveys were conducted to examine the effects of moral violation frames on climate engagement. Specifically, a moderated mediation model was tested. The model posits that message credibility mediates the relationship between moral frames and policy support, as well as the relationship between moral frames and behavior intention. Moreover, political ideology moderated the indirect effects of message credibility. Based on moral foundations theory, seven messages were designed to activate individualizing and binding moral foundations. The results indicated that credibility consistently mediated the effects of the moral violation frame on climate engagement and that liberal-leaning individuals were more likely to perceive an individualizing frame as more credible than a binding frame. However, this difference was smaller among conservative-leaning individuals, with evidence for this moderated mediation model found only for policy support among college students. This study suggests that credibility is key for effective moral violations arguments of climate change.
Radon Concentrations in Dwellings in the Mining Area—Are There Observed Effects of the Coal Mine Closure?
Authors: Wysocka Małgorzata , Nowak Sandra , Chałupnik Stanisław , Bonczyk Michał
Published: April 2022

The article presents the results of radon research, carried out in the area of the mining commune in the Upper Silesian Coal Basin (USCB), Poland. Past investigations in the 1990s on radon concentrations in buildings, located within the mining area, showed that the indoor radon concentrations measured in the area affected by mining were higher than in buildings located outside that area. Currently, all underground hard coal mines within the boundaries of the observed commune have been closed. In 2020, after the closure of the last active mine, radon measurements were started again. The current results of indoor radon concentrations were compared with the archival results from the 1990s. It was found that the radon concentration increased significantly in the basements of buildings where measurements were made in 1990, 2020, and 2021: the maximum values were 260 Bq/m3, 644 Bq/m3, and 1041 Bq/m3, respectively. Therefore, these questions were posed: Do the mine closure processes increase radon migration? How long is the period of the occurrence of changes in radon concentrations in buildings after the cessation of mining operations?
Co-Movement between Carbon Prices and Energy Prices in Time and Frequency Domains: A Wavelet-Based Analysis for Beijing Carbon Emission Trading System
Authors: Luo Rundong , Li Yan , Wang Zhicheng , Sun Mengjiao
Published: April 2022

This study aims to investigate the co-movement and lead–lag relationship between carbon prices and energy prices in the time–frequency domain in the carbon emission trading system (ETS) of Beijing. Based on wavelet analysis method, this study examines the weekly data on oil and natural gas prices and carbon prices in Beijing ETS from its establishment in November 2013 to April 2019. Empirical results show the following important findings: (1) Carbon and natural gas prices are mainly negatively correlated, with natural gas prices occupying a leading position in the 12–20 weeks frequency band, indicating that the increase (decrease) of natural gas price will lead to the decrease (increase) of carbon price; (2) carbon and oil prices show an unstable dependence relationship, and their leadership position in the market constantly changes. The partial wavelet coherency and partial phase differences vary greatly in different time–frequency domains, indicating that there is no stable coherency between oil prices and carbon prices. The estimation results prove the existence of coherency between the carbon and energy prices in the Beijing ETS. The research findings of this paper provide quantifiable references for investors to achieve risk control in asset allocation and investment portfolio in the ETS market.
Quality of Life and Mental Health in Children and Adolescents after the First Year of the COVID-19 Pandemic: A Large Population-Based Survey in South Tyrol, Italy
Authors: Barbieri Verena , Wiedermann Christian Josef , Kaman Anne , Erhart Michael , Piccoliori Giuliano , Plagg Barbara , Mahlknecht Angelika , Ausserhofer Dietmar , Engl Adolf , Ravens-Sieberer Ulrike
Published: April 2022

Background: Methodological heterogeneity of studies and geographical variation limit conclusions about the impact of the COVID-19 pandemic on the mental health of youth. This study aimed to explore the health-related quality of life and mental health of children and adolescents in the second year of the pandemic in South Tyrol, Italy. Methods: An online survey representative for the age and gender of the children and adolescents in South Tyrol was conducted among 5159 families with children and adolescents aged 7–19 years, between 28 May and 16 June 2021. The survey collecting parental ratings and self-rated questionnaires from children and adolescents aged 11–19 years included instruments to measure health-related quality of life (KIDSCREEN-10), mental health problems (SDQ), anxiety (SCARED), and depression (CES-DC). The results were compared with data from corresponding studies conducted in Germany. Results: Decreased health-related quality of life and increased conduct problems, peer-related mental health problems, anxiety, and depressive and psychosomatic symptoms in children and adolescents observed in the second year of the pandemic in Germany were confirmed in the second year in South Tyrol. Children and adolescents with low socioeconomic status, a migration background, and limited living space were significantly affected. Female sex and older age were associated with increased psychosocial problems and a positive family climate supported the mental health of children and adolescents during the pandemic. Conclusions: Confirmation of findings of decreased health-related quality of life and increased emotional problems after the first year of the pandemic supports the ongoing call for low-threshold health promotion, prevention, and early intervention programs to support children and adolescents who have been severely affected by the pandemic.
Public Safety Personnel Family Resilience: A Narrative Review
Authors: Cox Marilyn , Norris Deborah , Cramm Heidi , Richmond Rachel , Anderson Gregory S.
Published: April 2022

The families of public safety personnel (PSP) face demands that are unique to these occupations. Nonstandard work, trauma exposure, and dangerous work environments affect both workers and the families who support them. This narrative review aims to identify the stressors that PSP families experience and the support and resources needed to enhance family resilience. Due to a lack of research on PSP families, this review is a necessary first step to summarizing and interpreting a diverse body of research. The studies included addressed structural and emotional work-family conflict with reference to PSP sectors. A framework from the military family resiliency literature interprets the findings. Factors influencing family functioning and the availability and accessibility of resources provide clues about the type of skills and supports that PSP families rely on. Meaning-making, collaboration, a sense of coherence, and communication were identified as themes associated with intrafamilial processes. Extrafamilial themes included public perceptions, a lack of recognition for the roles families fulfill, and the need for information and education. The results suggest that the vulnerability of PSP families is variable and extrafamilial resources in the form of formal and informal supports are necessary to enhance family resiliency.
Shaping Pathways to Child Health: A Systematic Review of Street-Scale Interventions in City Streets
Authors: Ortegon-Sanchez Adriana , Vaughan Laura , Christie Nicola , McEachan Rosemary R. C.
Published: April 2022

Street-level built environment factors, for example, walking infrastructure, building density, availability of public transport, and proliferation of fast-food outlets can impact on health by influencing our ability to engage in healthy behaviour. Unhealthy environments are often clustered in deprived areas, thus interventions to improve the built environments may improve health and reduce inequalities. The aim of this review was to identify whether street-level built environment interventions can improve children’s health in high income countries. A secondary aim was to describe key built environment elements targeted in interventions and research gaps. A systematic review of published literature was conducted by a multi-disciplinary team. Ten intervention papers were included. Physical activity or play was the only health outcome assessed. Most interventions described temporary changes including closure of streets to traffic (N = 6), which were mainly located in deprived neighbourhoods, or the addition of technology to ‘gamify’ active travel to school (N = 2). Two studies reported permanent changes to street design. There was limited evidence that closing streets to traffic was associated with increases in activity or play and inconclusive evidence with changes to street design and using technology to gamify active travel. Our ability to draw conclusions was hampered by inadequate study designs. Description of interventions was poor. Rigorous evaluation of built environment interventions remains challenging. We recommend a multi-disciplinary approach to evaluation, explicit reporting of built environment indicators targeted in interventions and offer solutions to others working in this area.
Exploring Blue Spaces’ Effects on Childhood Leukaemia Incidence: A Population-Based Case–Control Study in Spain
Authors: Ojeda Sánchez Carlos , García-Pérez Javier , Gómez-Barroso Diana , Domínguez-Castillo Alejandro , Pardo Romaguera Elena , Cañete Adela , Ortega-García Juan , Ramis Rebeca
Published: April 2022

Background: Blue spaces have been a key part of human evolution, providing resources and helping economies develop. To date, no studies have been carried out to explore how they may be linked to paediatric oncological diseases. Objectives: To explore the possible relationship of residential proximity to natural and urban blue spaces on childhood leukaemia. Methods: A population-based case–control study was conducted in four regions of Spain across the period 2000–2018. A total of 936 incident cases and 5616 controls were included, individually matched by sex, year of birth and place of residence. An exposure proxy with four distances (250 m, 500 m, 750 m, and 1 km) to blue spaces was built using the geographical coordinates of the participants’ home residences. Odds ratios (ORs) and 95% confidence intervals (95%CIs) for blue-space exposure were calculated for overall childhood leukaemia, and the acute lymphoblastic (ALL) and acute myeloblastic leukaemia (AML) subtypes, with adjustment for socio-demographic and environmental covariates. Results: A decrease in overall childhood leukaemia and ALL-subtype incidence was found as we came nearer to children’s places of residence, showing, for the study as a whole, a reduced incidence at 250 m (odds ratio (OR) = 0.77; 95%CI = 0.60–0.97), 500 m (OR = 0.78; 95%CI = 0.65–0.93), 750 m (OR = 0.80; 95%CI = 0.69–0.93), and 1000 m (OR = 0.84; 95%CI = 0.72–0.97). AML model results showed an increasing incidence at closest to subjects’ homes (OR at 250m = 1.06; 95%CI=0.63–1.71). Conclusions: Our results suggest a possible association between lower childhood leukaemia incidence and blue-space proximity. This study is a first approach to blue spaces’ possible effects on childhood leukaemia incidence; consequently, it is necessary to continue studying these spaces—while taking into account more individualised data and other possible environmental risk factors.
Enhanced Hydrophobicity of Polymers for Protective Gloves Achieved by Geometric, Chemical and Plasma—Surface Modification
Authors: Irzmańska Emilia , Siciński Mariusz , Smejda-Krzewicka Aleksandra , Adamus-Włodarczyk Agnieszka , Makowicz Magdalena , Gozdek Tomasz
Published: April 2022

Gloves are one of the most important elements of personal protective equipment (PPE). To improve gloves properties, a lot of different methods of surface modifications are used. In this work, the application of geometric, chemical, and plasma surface modifications to improve the hydrophobicity of butyl (IIR) and silicone (MVQ) rubber are described. To characterise surface properties contact angle measurements, FT-IR spectroscopy and scanning electron microscopy were used. This study showed that when the chemical modification applied, the contact angle value increases compared to non-modified samples. In addition, plasma modification raised the contact angle value and smoothed the surface morphology. An increase in the polymer surfaces hydrophobicity was the observed effect of the three modifications of rubber.
Interaction of Pelargonium sidoides Compounds with Lactoferrin and SARS-CoV-2: Insights from Molecular Simulations
Authors: Iacovelli Federico , Costanza Gaetana , Romeo Alice , Cosio Terenzio , Lanna Caterina , Bagnulo Antonino , Di Maio Umberto , Sbardella Alice , Gaziano Roberta , Grelli Sandro , Squillaci Ettore , Miani Alessandro , Piscitelli Prisco , Bianchi Luca , Falconi Mattia , Campione Elena
Published: April 2022

(1) Background: Pelargonium sidoides extracts and lactoferrin are two important natural, anti-inflammatory, and antiviral agents, which can interfere with the early stages of SARS-CoV-2 infection. Molecular docking and molecular dynamics simulation approaches have been applied to check for the occurrence of interactions of the Pelargonium sidoides compounds with lactoferrin and with SARS-CoV-2 components. (2) Methods: Computational methods have been applied to confirm the hypothesis of a direct interaction between PEL compounds and the lactoferrin protein and between Pelargonium sidoides compounds and SARS-CoV-2 Spike, 3CLPro, RdRp proteins, and membrane. Selected high-score complexes were structurally investigated through classical molecular dynamics simulation, while the interaction energies were evaluated using the molecular mechanics energies combined with generalized Born and surface area continuum solvation method. (3) Results: Computational analyses suggested that Pelargonium sidoides extracts can interact with lactoferrin without altering its structural and dynamical properties. Furthermore, Pelargonium sidoides compounds should have the ability to interfere with the Spike glycoprotein, the 3CLPro, and the lipid membrane, probably affecting the functional properties of the proteins inserted in the double layer. (4) Conclusion: Our findings suggest that Pelargonium sidoides may interfere with the mechanism of infection of SARS-CoV-2, especially in the early stages.
AvaLife—A New Multi-Disciplinary Approach Supported by Accident and Field Test Data to Optimize Survival Chances in Rescue and First Aid of Avalanche Patients
Authors: Genswein Manuel , Macias Darryl , McIntosh Scott , Reiweger Ingrid , Hetland Audun , Paal Peter
Published: April 2022

Snow sports in the backcountry have seen a steep increase in popularity, and therefore preparedness for efficient companion and organized rescue is important. While technical rescue skills are widely taught, there is a lack of knowledge regarding first aid for avalanche patients. The stressful and time-critical situation for first responders requires a rule-based decision support tool. AvaLife has been designed from scratch, applying mathematical and statistical approaches including Monte Carlo simulations. New analysis of retrospective data and large prospective field test datasets were used to develop evidence-based algorithms exclusively for the avalanche rescue environment. AvaLife differs from other algorithms as it is not just a general-purpose CPR algorithm which has been slightly adapted for the avalanche patient. The sequence of actions, inclusion of the ≥150 cm burial depth triage criterion, advice to limit CPR duration for normothermic patients to 6 min in case of multiple burials and shortage of resources, criteria for using recovered subjects as a resource in the ongoing rescue, the adapted definition of “injuries incompatible with life”, reasoning behind the utmost importance of rescue breaths, as well as the updated BLS-iCPR algorithm make AvaLife useful in single and multiple burial rescue. AvaLife is available as a companion rescue basic life support (BLS) version for the recreational user and an advanced companion and organized rescue BLS version for guides, ski patrols and mountain rescuers. AvaLife allows seamless interoperability with advanced life support (ALS) qualified medical personnel arriving on site.
Creating Interprofessional Readiness to Advance Age-Friendly U.S. Healthcare
Authors: Waters Leland , Marrs Sarah A. , Tompkins Catherine J. , Fix Robert , Finucane Sheryl , Coogle Constance L. , Grunden Kevin , Ihara Emily S. , McIntyre Madeline , Parsons Pamela , Slattum Patricia
Published: April 2022

A successful interprofessional faculty development program was transformed into a more clinically focused professional development opportunity for both faculty and clinicians. Discipline-specific geriatric competencies and the Interprofessional Education Collaborative (IPEC) competencies were aligned to the 4Ms framework. The goal of the resulting program, Creating Interprofessional Readiness for Complex and Aging Adults (CIRCAA), was to advance an age-friendly practice using evidence-based strategies to support wellness and improve health outcomes while also addressing the social determinants of health (SDOH). An interprofessional team employed a multidimensional approach to create age-friendly, person-centered practitioners. In this mixed methods study, questionnaires were disseminated and focus groups were conducted with two cohorts of CIRCAA scholars to determine their ability to incorporate learned evidence-based strategies into their own practice environments. Themes and patterns were identified among transcribed interview recordings. Multiple coders were used to identify themes and patterns and inter-coder reliability was assessed. The findings indicate that participants successfully incorporated age-friendly principles and best practices into their own work environments and escaped the silos of their disciplines through the implementation of their capstone projects. Quantitative data supported qualitative themes and revealed gains in knowledge of critical components of age-friendly healthcare and perceptions of interprofessional collaborative care. These results are discussed within a new conceptual framework for studying the multidimensional complexity of what it means to be age-friendly. Our findings suggest that programs such as CIRCAA have the potential to improve older adults’ health by addressing SDOH, advancing age-friendly and patient-centered care, and promoting an interprofessional model of evidence-based practice.
Studyholism and Study Engagement in Adolescence: The Role of Social Anxiety and Interpretation Bias as Antecedents
Authors: Loscalzo Yura , Giannini Marco
Published: April 2022

Studyholism (or obsession toward study) is a new potential clinical condition that, in contrast with Study Engagement, is associated with negative outcomes. However, previous studies showed that both Studyholism and Study Engagement predict social impairment due to study. Therefore, we analyzed the role of social anxiety and interpretation bias as predictors of Studyholism and Study Engagement in 541 adolescents (Mage = 16.30 ± 1.59; 66% girls). We performed a path analysis model, MANOVAs, and Mann–Whitney tests. Among the main findings, social anxiety is a positive predictor of both Studyholism and Study Engagement. Hence, this provides further support to the conceptualization of Studyholism as an OCD-related disorder (or as an internalizing disorder) and suggests the need of screening socially anxious adolescents for the presence of Studyholism and engaged students for the presence of high social anxiety. Moreover, Studyholism is predicted by a negative interpretation style in non-social situations, while a positive interpretation style predicts Study Engagement in social and non-social situations. Hence, Studyholism and social anxiety are two different diagnoses, even if social anxiety might fuel Studyholism. Moreover, interventions to reduce Studyholism should decrease the tendency to interpret non-social situations negatively or neutrally.
Handgrip Strength and Cognitive Function among Elderly Koreans: Insights from the Korean Longitudinal Study of Ageing
Authors: Kim Keuntae , Kim Hyemi
Published: April 2022

This study aims to assess handgrip strength as a predictor of cognitive decline within men and women in Korea. A random-intercept logistic regression is fit to estimate the status changes in cognitive function throughout all rounds of the KLoSA, a nationally-representative survey of adults aged 45 years and older. Males in the highest quartile were 71.9% less likely to experience cognitive impairment than those in the lowest quartile. The odds of cognitive impairment for men in the third and second quartiles reduced by 62.6% and 60.4% respectively. Similarly, the odds of cognitive impairment for women declined as 72.7%, 63.0%, and 41.8% for fourth, third, and second quartile, respectively, compared with the lowest quartile. These results imply that assessing and monitoring handgrip strength may enable us to identify subgroups of the elderly with higher likelihood of cognitive impairment in Korea.
Applicability of Novel Urinary Biomarkers for the Assessment of Renal Injury in Selected Occupational Groups in Sri Lanka: A Comparative Study with Conventional Markers
Authors: Ekanayake E. M. D. V. , Gunasekara T. D. K. S. C. , De Silva P. Mangala C. S. , Jayasinghe Sudheera , Chandana E. P. S. , Jayasundara Nishad
Published: April 2022

Screening approaches with more robust biomarkers, are of the utmost importance in the characterization of renal injuries, particularly among communities with high burdens of chronic kidney disease of uncertain etiology (CKDu). The present study aimed to assess the utility of two emerging biomarkers: kidney injury molecule (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) in predicting renal injury in different occupational groups in Sri Lanka. A cross-sectional study was conducted with six occupational groups (n = 188): fisherfolk (FF), paddy farmers (PF), sugarcane farmers (SF), factory workers (FW) and plantation workers (PW) to assess the predictive performance of KIM-1 and NGAL against a CKDu patient (PT) group (n = 40). The median KIM-1 levels of the study groups; FF, PF, SF, FW, PW and PT were 0.67, 0.59, 0.49, 1.62, 0.67 and 5.24 ng/mgCr, respectively, while the median NGAL levels were 1.16, 2.52, 1.42, 1.71, 1.06 and 22.41 ng/mgCr respectively. In ROC analysis to predict CKDu susceptibility, the area under the curve for KIM-1 ranged from 0.88 to 0.99 for the study groups, and in overall analysis, the sensitivity and specificity were 100% and 96%, respectively, for a cutoff value of 2.76 ng/mgCr. Similarly, for NGAL the range of AUC was 0.78–0.94, and a cutoff value of 3.12 ng/mgCr produced 88% sensitivity and 82% specificity. Compared with conventional markers, KIM-1 was the best biomarker for the characterization of renal injury in the participants of the occupational groups. With further validations, KIM-1 may be adopted as a prognostic marker to identify early renal injury and CKDu susceptibilities in community screening.
The Effectiveness of Mental Health Literacy Curriculum among Undergraduate Public Health Students
Authors: Lai Hsuan-Jung , Lien Yin-Ju , Chen Kai-Ren , Lin Yu-Kai
Published: April 2022

Mental health literacy (MHL) plays an important role in public health. Improving MHL can promote mental health at the individual and public levels. To date, no published studies have assessed the effectiveness of MHL curriculum interventions among undergraduate public health students. The participants in this study were undergraduate public health students (n = 48) who were enrolled in an 18-week MHL curriculum for 100 min per week. MHL was assessed using the Mental Health Literacy Scale for Healthcare Students. A paired sample t-test was performed to examine the immediate and delayed effects of the MHL curriculum. The total MHL score significantly improved, and a moderate effect size was found directly after the intervention and six weeks later. There were significant differences in the recognition of mental illness (p < 0.01), help-seeking efficacy (p < 0.05), and help-seeking attitude (p < 0.05) in the five components of MHL between pre- and post-test. Furthermore, significant improvements were obtained for the maintenance of positive mental health (p < 0.05) and reduction of mental illness stigma (p < 0.001) between the pre-test and follow-up. Our findings provide evidence for the development and implementation of an MHL curriculum for public health education.
Lifelong Lung Sequelae of Prematurity
Authors: Di Filippo Paola , Dodi Giulia , Ciarelli Francesca , Di Pillo Sabrina , Chiarelli Francesco , Attanasi Marina
Published: April 2022

The clinical, functional, and structural pattern of chronic lung disease of prematurity has changed enormously in last years, mirroring a better perinatal management and an increasing lung immaturity with the survival of increasingly premature infants. Respiratory symptoms and lung function impairment related to prematurity seem to improve over time, but premature birth increases the likelihood of lung function impairment in late childhood, predisposing to chronic obstructive pulmonary disease (COPD). It is mandatory to identify those individuals born premature who are at risk for developing long-term lung disease through a better awareness of physicians, the use of standardized CT imaging scores, and a more comprehensive periodic lung function evaluation. The aim of this narrative review was to provide a systematic approach to lifelong respiratory symptoms, lung function impairment, and lung structural anomalies in order to better understand the specific role of prematurity on lung health.
Inequality in the Utilization of Breast Cancer Screening between Women with and without Disabilities in Taiwan: A Propensity-Score-Matched Nationwide Cohort Study
Authors: Inchai Puchong , Tsai Wen-Chen , Chiu Li-Ting , Kung Pei-Tseng
Published: April 2022

Because of the difficulties in accessing medical care, the likelihood of receiving breast cancer screening may be low for women with disabilities. We aimed to investigate differences in the utilization of breast cancer screening among women with and without disabilities. Participants included women with and without disabilities from 2004 to 2010, and it was observed whether the participants had received a breast cancer screening during 2011 and 2012. Propensity-score matching was employed to match disabled women with non-disabled women (1:1). Data sources included the National Health Insurance Research Database, the Cancer Screening Database, and the Disability Registration File. Conditional logistic regression was performed to examine the odds ratios (ORs) that both groups would undergo breast cancer screening. The proportion of women with disabilities who received breast cancer screening was 18.33%, which was significantly lower than that of women without disabilities (25.52%) (p < 0.001). Women with dementia had the lowest probability of receiving a mammography examination (OR = 0.34; 95% CI: 0.28–0.43), followed by those with multiple disabilities (OR = 0.43; 95% CI: 0.40–0.47) and intellectual disabilities (OR = 0.45; 95% CI: 0.41–0.50). In conclusion, compared to women without disabilities, those with disabilities were less likely to undergo breast cancer screening.
Optimizing County-Level Land-Use Structure Method: Case Study of W County, China
Authors: Tang Lijing , Yang Yuanyuan , Wang Dongyan , Wei Qing
Published: April 2022

Planning has a direct impact on the formation of China’s land-use structure. In order to better play its role, China has proposed Multiple Planning Integration. As a part of reform for promoting ecological progress, it should have the concept of ecological progress, as well as the formation of land-use structure. Based on these, we focused on China’s land at the county level and developed a method to optimize its land-use structure catering to Multiple Planning Integration and ecological progress, using W County as a case study. This method mainly comprises three parts: calculating the demand area; calculating the carrying capacity; and optimizing the land-use structure. Models are constructed based on the ecological footprint theory. We found that setting unified targets as the link to integrating plans can effectively form the optimal land-use structure at county-level in the manner of “targets set—area determined”. There are three ways to integrate the concept of ecological progress into the optimization process. First, unified targets should be set for both ecological protection and socio-economic development, and priority should be given to the implementation of ecological protection; that is, in the process of optimization, the land area for the ecological redline of a county needs to be initially determined. Second, when optimizing the land-use structure, we should consider the carrying capacity of county-level land, in relation to demand related to the implementation of socio-economic development. Third, ecological balance should be ensured by comparing demands and the carrying capacities and maximizing the ecological service values of the land, which are important principles for determining the land-use structure. Our research provides a reference for optimizing land-use structure at the county level in China.
Platelet Rich Plasma in Gynecology—Discovering Undiscovered—Review
Authors: Streit-Ciećkiewicz Dominika , Kołodyńska Aleksandra , Futyma-Gąbka Karolina , Grzybowska Magdalena , Gołacki Jakub , Futyma Konrad
Published: April 2022

Regenerative medicine combines elements of tissue engineering and molecular biology aiming to support the regeneration and repair processes of damaged tissues, cells and organs. The most commonly used preparation in regenerative medicine is platelet rich plasma (PRP) containing numerous growth factors present in platelet granularities. This therapy is increasingly used in various fields of medicine. This article is a review of literature on the use of PRP in gynecology and obstetrics. There is no doubt that the released growth factors and proteins have a beneficial effect on wound healing and regeneration processes. So far, its widest application is in reproductive medicine, especially in cases of thin endometrium, Asherman’s syndrome, or premature ovarian failure (POF) but also in wound healing and lower urinary tract symptoms (LUTS), such as urinary incontinence or recurrent genitourinary fistula auxiliary treatment. Further research is, however, needed to confirm the effectiveness and the possibility of its application in many other disorders.
Cytotoxicity of Newly Synthesized Quinazoline–Sulfonamide Derivatives in Human Leukemia Cell Lines and Their Effect on Hematopoiesis in Zebrafish Embryos
Authors: Alqahtani Ali S. , Ghorab Mostafa M. , Nasr Fahd A. , Ahmed Mohammad Z. , Al Mishari Abdullah A. , Attia Sabry M. , Farooq Khan Muhammad
Published: April 2022

Many quinazoline derivatives with pharmacological properties, such as anticancer activity, have been synthesized. Fourteen quinazoline derivatives bearing a substituted sulfonamide moiety (4a–n) were previously synthesized and fully characterized. These compounds exerted antiproliferative activity against cell lines derived from solid tumors. Herein, the antileukemic activities of these compounds (4a–n) against two different leukemia cell lines (Jurkat acute T cell and THP-1 acute monocytic) were investigated. Our investigation included examining their activity in vivo in a zebrafish embryo model. Remarkably, compounds 4a and 4d were the most potent in suppressing cell proliferation, with an IC50 value range of 4–6.5 µM. Flow cytometry analysis indicated that both compounds halted cell progression at the G2/M phase and induced apoptosis in a dose-dependent manner. RT-PCR and Western blot analyses also showed that both compounds effectively induced apoptosis by upregulating the expression of proapoptotic factors while downregulating that of antiapoptotic factors. In vivo animal toxicity assays performed in zebrafish embryos indicated that compound 4d was more toxic than compound 4a, with compound 4d inducing multiple levels of teratogenic phenotypes in zebrafish embryos at a sublethal concentration. Moreover, both compounds perturbed the hematopoiesis process in developing zebrafish embryos. Collectively, our data suggest that compounds 4a and 4d have the potential to be used as antileukemic agents.
Materials Based on Quaternized Polysulfones with Potential Applications in Biomedical Field: Structure–Properties Relationship
Authors: Bargan Alexandra , Onofrei Mihaela Dorina , Stoica Iuliana , Doroftei Florica , Dunca Simona , Filimon Anca
Published: April 2022

Starting from the bactericidal properties of functionalized polysulfone (PSFQ) and due to its excellent biocompatibility, biodegradability, and performance in various field, cellulose acetate phthalate (CAP) and polyvinyl alcohol (PVA), as well as their blends (PSFQ/CAP and PSFQ/PVA), have been tested to evaluate their applicative potential in the biomedical field. In this context, because the polymer processing starts from the solution phase, in the first step, the rheological properties were followed in order to assess and control the structural parameters. The surface chemistry analysis, surface properties, and antimicrobial activity of the obtained materials were investigated in order to understand the relationship between the polymers’ structure–surface properties and organization form of materials (fibers and/or films), as important indicators for their future applications. Using the appropriate organization form of the polymers, the surface morphology and performance, including wettability and water permeation, were improved and controlled—these being the desired and needed properties for applications in the biomedical field. Additionally, after antimicrobial activity testing against different bacteria strains, the control of the inhibition mechanism for the analyzed microorganisms was highlighted, making it possible to choose the most efficient polymers/blends and, consequently, the efficiency as biomaterials in targeted applications.
Novel Bacillus ginsengihumi CMRO6 Inhibits Adipogenesis via p38MAPK/Erk44/42 and Stimulates Glucose Uptake in 3T3-L1 Pre-Adipocytes through Akt/AS160 Signaling
Authors: Lee Kyung Dong , Ilavenil Soundharrajan , Karnan Muthusamy , Yang Chul-Ju , Kim Dahye , Choi Ki Choon
Published: April 2022

The health benefits of probiotics have been known for decades, but there has only been limited use of probiotics in the treatment of obesity. In this study, we describe, for the first time, the role of cell-free metabolites (CM) from Bacillus ginsengihumi-RO6 (CMRO6) in adipogenesis and lipogenesis in 3T3-L1 pre-adipocytes. The experimental results show that CMRO6 treatment effectively reduced lipid droplet accumulation and the expression of CCAAT/enhancer-binding protein α and β (C/EBPα and C/EBPβ), peroxisome proliferator-activated receptor γ (PPAR-γ), serum regulatory binding protein 1c (SREBP-1c), fatty acid-binding protein 4 (FABP4), fatty acid synthase (FAS), acetyl CoA carboxylase (ACC), phosphorylated p38MAPK, and Erk44/42. Additionally, CMRO6 treatment significantly increased glucose uptake and phosphorylated Akt (S473), AS160, and TBC1D1 protein expressions. Considering the results of this study, B. ginsengihumi may be a novel probiotic used for the treatment of obesity and its associated metabolic disorders.