bluuebunny/crossref_metadata_2025 huggingface dataset:
STATUS, PROBLEMS AND PROSPECTS OF DEVELOPMENT OF SPECIALIZED SURGICAL CARE FOR PATIENTS WITH MAXILLOFACIAL PATHOLOGY IN KAZAN AND WAYS OF THEIRSOLUTION
Authors: Ксембаев Саид , Ksembaev Said , Иванов Олег , Ivanov Oleg , Торгашова Ольга , Torgashova Ol'ga
Published: October 2019

Subject of the study: current state of the organization and provision of specialized care to patients with pathology of the maxillofacial region in Kazan, the problems of improving the quality of this type of medical care and their solutions.

The purpose — is to study organization and provision of specialized surgical care to patients with pathology of the maxillofacial region based on the results of work the Department of maxillofacial surgery of the city clinical hospital No. 7 of Kazan. The volume and nature of the care provided in the conditions of the round-the-clock dental hospital are defined. To determine the factors that reduce the quality of specialized surgical care for patients by analyzing data from the medical records of hospitalized and outpatient patients over the past 3 years.

Material and methods. Uses analytical and quantitative-qualitative methods of retrospective study of the main indicators of medical work of the Department of maxillofacial surgery of the Kazan city clinical hospital No. 7 and patient records for 2016-2018.

Results. Based on the analysis of the results of specialized Department of maxillofacial surgery determined the evolution of the number of patients according to nosological groups for 3 years, assess the volume of aid, to change its structure in favor of increasing the volume of outpatient surgical care while maintaining the number and structure of hospital morbidity. The evaluation of low efficiency of interaction between dental clinics and hospital, organizational and methodological approaches to the provision of this type of care.

Conclusion. Analysis of the data obtained in the course of the study revealed a number of problems in routing patients for urgent and planned indications, in providing assistance at the prehospital stage in dental clinics, in posthospital rehabilitation of patients.
Modelo de convergencia e integración de servicios de telecomunicaciones de la Fuerza Aérea Colombiana para apoyar operaciones coordinadas: caso Policía Nacional
Authors: Vásquez Ruiz María Carolina
Published: October 2019

Los sectores de las Tecnologías de la Información y la Comunicación (TIC) continuamente se someten a retos. Desafíos que hoy por hoy, con los diferentes desarrollos tecnológicos, integrado a los actuales requerimientos de los clientes y necesidades empresariales, generan la necesidad de la interconexión entre las diferentes plataformas de telecomunicaciones. Esta investigación enfocará sus esfuerzos en formular una solución que permita la convergencia e integridad de los sistemas de telecomunicaciones de la Fuerza Aérea Colombiana (FAC) con los sistemas de la Policía Nacional (PNC), todo esto encaminado a facilitar el proceso de toma de decisiones durante el desarrollo de operaciones coordinadas. Para esto, es imprescindible que las tecnologías tengan la posibilidad de ser actualizadas a los nuevos lineamientos del mercado global, mediante la implementación de software y hardware que interconecten los sistemas de información actuales. Así mismo, se busca analizar la información disponible en varios escenarios, tanto el regulatorio-administrativo, operativo, técnico, como de talento humano entre los años 2014 al 2016. De conformidad con lo anterior, se desarrolla un proceso investigativo, donde los resultados logrados son interesantes. Ya que de manera significativa las hipótesis planteadas son validadas, de acuerdo con los resultados obtenidos aplicando los instrumentos de medición cualitativos y cuantitativos llevados a cabo durante la metodología de la investigación. Resultados que logró evidenciar que las plataformas de tecnologías de la información de la FAC y PONAL presenta una divergencia, la cual causa incompatibilidad para alcanzar una comunicación asertiva para el desarrollo de operaciones coordinadas. Esta investigación, bajo el enfoque de recursos y capacidades de ambas instituciones, buscó un camino para lograr comunicaciones seguras, evaluando la interoperabilidad entre ambas, con el fin de un mayor comando y control de las operaciones. A su vez pretende, que el modelo planteado pueda ser utilizado en futuros desarrollos tecnológicos orientados a operaciones coordinas con otras entidades no militares, como la Fiscalía, Cruz Roja, Defensa Civil, entre otros.
Transporte aéreo estratégico militar en las operaciones militares modernas
Authors: Delgado Morán Juan José , Jiménez Reina Jonnathan , Jiménez Reina Roger
Published: October 2019

Debido a la urgencia de las Operaciones Militares Modernas, las fuerzas necesitan de un medio que las proyecte en tiempos relativamente cortos, donde la Capacidad de Transporte Aéreo Estratégico Militar adquiere un papel preponderante. Asimismo, es importante destacar la influencia de la tecnología en el medio aéreo, que ha permitido que la capacidad de carga y pasajeros sea cada vez mayor y con menos servidumbres terrestres. Claramente la proyección de fuerzas puede realizarse por otros medios de locomoción, pero la velocidad y el aumento paulatino de las bodegas de carga hacen que el medio aéreo pueda dotar a las fuerzas de la movilidad y flexibilidad que se requieren en los conflictos actuales. Es por esto, por lo que la presente investigación tiene como objetivo proporcionar un análisis de la importancia e implicaciones de la Capacidad de Transporte Aéreo Estratégico Militar en las Operaciones Militares Modernas.
Estimación de la Polar de Arrastre de Aeronave Agrícola Colombiana mediante Pruebas de Vuelo
Authors: Palomino Andrés
Published: October 2019

El presente artículo muestra el proceso de obtención de la polar de arrastre de una aeronave agrícola de diseño y fabricación colombiana. El trabajo consistió en la determinación de una curva generalizada de potencia (Método PIW-VIW) mediante toma de datos en pruebas de vuelo a diferentes altitudes y velocidades. Los resultados obtenidos se dan en forma de parámetros aerodinámicos, siendo los más importantes: el coeficiente de arrastre parásito a cero sustentación (CDo) y el factor de eficiencia de Oswald (e).
Sosyal Medya Bağlamında Dijital Vatandaşlık: TRT İstanbul Radyosu Prodüktörleri Üzerinden Bir Değerlendirme
Authors: KIRIK Ali Murat , BÖLÜKBAŞ Kenan , CENGİZ Gönül
Published: October 2019

İnternet
ve teknolojinin toplumlar üzerinde yarattığı etki, geleneksel vatandaşlık
olgusunu dijital ortama da taşımış ve bu durum, dijital vatandaşlık kavramını
ortaya çıkarmıştır. Dijital vatandaşlık olgusu; düzenli, etkili internet
erişimi ve bilişim okuryazarlığını zorunlu kılmaktadır. Bu
çalışma, günümüzün vazgeçilmez iletişim ve paylaşım araçlarından biri olan
sosyal medyayı, dijital vatandaşlık bağlamında inceleyerek internet
kullanıcılarının sorumluluklarına dikkat çekmiştir. Bu çalışmayla aynı zamanda,
dijital vatandaşlığın doğru şekilde kullanılabilmesi amacıyla bireylere
sağlanan eğitim olanakları da araştırılmıştır. Basit tesadüfi örnekleme olarak
TRT İstanbul Radyosunda göreve yeni başlayan program yapımcıları yani
prodüktörler (10 kişi) ile yapılan çalışmada, sosyal bilimlerde en sık
kullanılan veri toplama yöntemlerinden biri olan görüşme tekniği
kullanılmıştır. Prodüktörlere Ribble’in dijital vatandaşlık kavramını tanımlamakta
kullandığı boyutlar çerçevesinde hazırlanmış on bir soru yöneltilmiştir.

Görüşmeler
sonucunda katılımcılar dijital vatandaşlık konusunda yeteri kadar bilgiye sahip
olmadıklarını ve bu alanda ülkemizde gerekli eğitimlerin verilmediğini vurgulamaktadır.
Çalışmadan elde edilen bulgular, Ribble’in tanımladığı kavramın günlük yaşamın
gerektirdiği vatandaşlık sorumlulukları ile dijital sorumluluklar arasında
doğrudan bağlantısı olduğu sonucuna ulaşmakta ve sosyal medyanın tanımlanan bu
sorumluluklar çerçevesinde kullanılmasının önemine dikkat çekmektedir.
Türkiye Türkçesi Ağızlarındaki Bazı Kelimelerin Kökeni Üzerine 2
Authors: GÜZEL Ferdi
Published: October 2019

Türkiye
Türkçesi ağızlarında yer alan kelimelerin kökeni ile ilgili çalışmaların
yeterli düzeyde olduğu söylenemez. Etimolojik çalışmalarda genellikle yazı
dilinde yer alan kelimeler ele alınmakta, ağızlardaki kelimelere pek değinilmemektedir.
Bu çalışmada Türkiye Türkçesi ağızlarında bulunan 15 kelimenin yapısı
üzerinde
durulmuştur. Birçoğu arkaik özellik taşıyan ve Türkiye Türkçesi yazı dilinde
unutulmuş
olan bu kelimeler şunlardır: bernek, biniç, çıkla, düzen,
eŋir, haflek, hayinseme-, hemicik/ hemicük, maymak, soyha/ soyka, yığaç,
yordu-, yoşa-, yörpek, yüle-. Bu makalede, daha önce bazı etimolojik çalışmalarda ele alınıp incelenmiş
olan bu kelimelerden bazılarının yapısı hakkında farklı görüşler ileri
sürülmüş, bazı kelimelerin kökeni ve yapısı hakkındaki görüşlere katkı
sağlayacak örnek kelimeler gösterilmiştir. Zengin bir söz varlığına sahip
olan Türkiye Türkçesi ağızları, Türk dili araştırmaları için büyük bir önem taşımaktadır. Türkiye Türkçesi ağızlarındaki kelimelerin
etimolojisi üzerine yapılacak çalışmalar, Türk dili tarihindeki pek çok problemin
çözümlenmesine, pek çok kelimenin yapısının
aydınlatılmasına katkı sağlayacaktır.
Sovyet Rusya’da “Öteki”nin Yeniden İnşası Sürecinde Olumsuz Adlandırmalar
Authors: SARAÇ Hanife
Published: October 2019

Sovyet iktidarı sosyalist düzenin
tam manasıyla işlemeye başladığı İç Savaş sonrası dönemde kolektif kimliğin
şekillenmesi için çaba göstermiştir. Bu bağlamda yeni sosyal gerçeklikle
birlikte şekillenen “biz” ve “öteki” kimliklerinin oluşumuna katkı sunan
unsurlardan biri de olumsuz adlandırmalar olur. Parti’nin güçlenme döneminde
sosyalist ideolojinin cephe aldığı kapitalistler ve burjuva sınıfı “öteki” ilan
edilirken, İç Savaş sonrası dönemde ise kendilerine muhalefet eden tüm birimler
Sovyet halkının karşısında konumlandırılarak “öteki”leştirilir. “Biz”den olan
vatansever, ülke için çalışan, düzenin koruyucusu iken diğer tarafta “öteki”
sosyal düzeni bozan, ülkesine zarar veren ve halk düşmanıdır. Sosyalist düzen
oturtulmadan önce daha çok Bolşevik lider kadrosunun söylemleri üzerinden
işleyen bir dışlama mekanizması etkinken, ilerleyen dönemde yaftalama ve
etiketleme şeklinde yürütülen bir “ötekileştirme” süreci dikkat çeker. Bu
çalışmada Sovyetlerce geliştirilen “istenmeyen”in “öteki”leştirilmesi yaklaşımı
üzerinde durulmakta, bu süreçte istifade edilen ve olumsuz adlandırmalara örnek
teşkil eden kelimeler incelenmektedir.
İngiliz Doğu Hindistan Şirketinin Kuruluş Aşamasında İngilizlerin Hindistan’a Yerleşme Çabaları
Authors: KUŞ BÜYÜKTAŞ Canan
Published: October 2019

Bu çalışmanın
zaman sınırlılığı 17. yüzyılın başlarında Babürlü Devleti’nin hükümdarı
Cihangir Şah Dönemi’ne isabet etmektedir. Çalışmanın amacı ise, İngilizlerin
Hind deniz ticaretine sahip olmak için Hindistan’da varlık gösterdiği ilk
yıllarda, seyyah, tüccar ve elçiler aracılığı ile Hindistan’da tutunma
çabalarının neler olduğunun açıklanmasıdır. Bu çalışmada ayrıca İngilizlerin
Babürlü Devleti’nden izin alarak Surat’ta açtıkları fabrikanın işleyişi
hakkında bazı bilgiler sunmaktır. Böylelikle bu bilgiler ışığında Hindistan’ın kaderini etkileyen İngiliz Doğu Hindistan Şirketinin kuruluş
aşamasında ona imkân oluşturan etkenlerin tespit edilmesi hedeflenmektedir.
Çalışmada yararlanılan kaynaklar ise, döneme ilişkin siyasetname, seyahatname
gibi ana kaynaklar ile çeşitli yerli ve yabancı yardımcı kaynaklardır.
Trabzon İlini Kalkındırma Cemiyeti’nin Kuruluşu Faaliyetleri ve Bu Kapsamda Ortaya Çıkan Bir Mahalle: Kalkınma Mahallesi
Authors: BAŞKAYA Muzaffer
Published: October 2019

Tarihi İpek Yolu’nun Karadeniz’e
çıkış kapılarından biri olan Trabzon, bu özelliği sayesinde oldukça canlı bir
ticari hayata sahne olmuştur. Trabzon’un ticari bünyesine zarar veren gelişme
1914 yılında yaşanmış ve Birinci Dünya Savaşı’nın yıkıcı etkisi, başta tarihi
İran transit ticareti olmak üzere Trabzon ekonomisini sarsmış ve böylece
Trabzon, geri dönülemeyecek bir biçimde ticaret merkezi olma konumunu
yitirmiştir. Cumhuriyetin ilanı sonrası kenti eski parlak günlerine döndürmek
için bazı projeler ortaya atılsa da değişen şartların da etkisiyle Trabzon,
geçmişteki canlı ekonomik yapısını kaybetmiştir. 27 yıllık Tek Parti İktidarı Döneminde
beklenen atılımların gerçekleştirilemediğini gören ve doğal olarak ümitsizlik
içine düşen Trabzon kamuoyu 1950 yılında yaşanan iktidar değişikliğini bir
fırsat olarak değerlendirmiştir. Yeni iktidarın yeni bir ekonomik anlayışla
Trabzon’a ve kentin meselelerine sahip çıkacağını ümit eden bir kısım
müteşebbis bu konudaki beklentileri daha yüksek bir sesle dile getirmek
amacıyla merkezi Ankara’da olmak üzere Trabzon İlini Kalkındırma Cemiyeti adı
altında bir örgütlenme içine girmişlerdir. Trabzon’u Kalkındırma Cemiyeti en
önemli hamlesini 1956 yılında gerçekleştirmiş ve Değirmendere’de 200 evden
oluşan modern bir mahalle kurulmasına karar verilmiştir.
Siber Mobbing Ölçeği Geçerlilik ve Güvenirlik Çalışması
Authors: EKİNCİ Oğuzhan , KAYAPALI YILDIRIM Seda
Published: October 2019

İnsanlara iletişim, bilgi, eğlence ve yaratıcılık bağlamında birçok
yeni imkân sunan internet erişimli mobil cihazlar, günümüzde özellikle gençler
için büyük bir ihtiyaca dönüşmüş ve günlük yaşamın giderek çevrimiçi bir hâl almasını sağlamıştır. Ancak bu alandaki her
teknolojik gelişme, yeni sorunların ortaya çıkmasına ve gerçek dünyadaki
sorunlu alanların sanal uzaya taşınmasına neden olmuştur. Bu yeni
sorunlardan/fenomenlerden biri de siber mobbingtir.
Akıllı telefonlar, bilgisayarlar ya da internet erişimli başka aygıtlar
yardımıyla sanal uzayda/ortamlarda birinin utanç verici ya da çok samimi
fotoğraf ve videolarını yayınlamak, biri hakkında söylentiler oluşturmak ya da
yaymak, şiddet içerikli paylaşımlar yapmak, artık günümüz dünyasının gerçekleri
arasında yer almaktadır. Bu makalenin amacı, siber mobbing olgusunun kavramsal
çerçevesini çizmek, onu geleneksel mobbingden ayıran farkları ortaya koymak ve
kapsamlı bir ampirik çalışmayla ele alarak Türkçe ölçeğin geçerlilik ve
güvenirlik çalışmasını yapmaktır. Bu doğrultuda 637 katılımcıdan elde edilen
verilere SPSS ve LISREL programları kullanılarak Açımlayıcı ve Doğrulayıcı Faktör Analizleri yapılmıştır. Yüksek güvenirlik
gösteren 8 boyut ve 62 ifade oluşturulmuştur.
Bir Hidroksiazo Bileşiği Kullanılarak Gerçek Örneklerde Nikelin Eser Miktarlarının Spektrofotometrik Tayini
Authors: Güray Tufan
Published: October 2019

Bu
makalede, nikel tayini için,
herhangi bir ön deriştirme işlemi uygulamadan, pH 5,5 (5-6) 'da 2,3,4,6/-tetrahidroksi-3/-sülfoazobenzen
(THSA) ile şelat oluşturarak seçici ve duyarlı bir spektrofotometrik yöntem
önerilmiştir. Metal ligand oranı 1: 1 olan kompleksin, 485 nm'de, molar
absorplama katsayısı 1,60 ×104 L mol−1 cm−1
'dir. Kompleks bileşik 3 saat kararlılığını korumaktadır. Ayrıca, 50 °C’ye kadar bozulmadan kalır. Geliştirilen yöntem
0,040-2,348 µg mL−1 Ni (II) tayin aralığında Beer’in kanununa uyar.
Toprak alkali elementler, alkalin elementler, nadir toprak elementler,
halojenürler, fosfatlar, askorbik asit ve katyonlar nikel tayini engellemez. Önerilen
yöntem hızlı ve basittir ve nikel tayini için sertifikalı alaşımlara ve çevre
suyu örneklerine kolayca uygulanabilir.
Asymptotics for the Radon transform on hyperbolic spaces
Authors: ANDERSEN Nils Byrial , FLENSTED-JENSEN Mogens
Published: October 2019

Let G/H be a hyperbolic space over R; C or H; and let K be a maximal compact subgroup of G. Let D denote a certain explicit invariant differential operator, such that the non-cuspidal discrete series belong to the kernel of D. For any L^2-Schwartz function f on G/H we prove that the Abel transform A(Df) of Df is a Schwartz function. This is an extension of a result established in [2] for K-finite and K∩H-invariant functions.
Core of a matrix in max algebra and in nonnegative algebra: A survey
Authors: BUTKOVIC Peter , SCHNEIDER Hans , SERGEEV Sergei
Published: October 2019

This paper presents a light introduction to Perron-Frobenius theory in max algebra and in nonnegative linear algebra, and a survey of results on two cores of a nonnegative matrix. The (usual) core of a nonnegative matrix is defined as ∩ k≥1 span+ (A k ) , that is, intersection of the nonnegative column spans of matrix powers. This object is of importance in the (usual) Perron-Frobenius theory, and it has some applications in ergodic theory. We develop the direct max-algebraic analogue and follow the similarities and differences of both theories.
Bergman–Hartogs domains and their automorphisms
Authors: ROOS Guy
Published: October 2019

For Cartan–Hartogs domains and also for Bergman–Hartogs domains, the determination of their automorphism groups is given for the cases when the base is any bounded symmetric domain and a general bounded homogeneous domain respectively.
The Relationship between Regular Sinusoidal Waves in the Tissue at Lung-related Acupuncture Points and the Respiration Pacesetter Mechanism
Authors: Kovich Fletcher
Published: October 2019

Background: While investigating the real-time impedance at acupuncture points (acupoints), it was found that regular sinusoidal waves were present that corresponded to the pulsing of certain organs, such as respiration and duodenal waves, the stomach’s slow waves, and also the heart’s beating.Methods: This study investigated such respiration waves at lung-related acupoints to clarify their relation to the respiration pacesetter mechanism. The impedance at key acupoints was monitored in real time while the patients’ breathing slowed after exercise.Results: In all 7 patients studied, the respiration and heart-beat waves matched the rates in the corresponding organs at rest, and did not vary markedly due to exercise. In 3 of the 7 patients, their post-exercise respiration rate exactly matched that of their duodenal waves, but then dropped, stepwise, back to their usual respiration rate. In the other 4 patients, their post-exercise respiration rate did not reach that of their duodenal waves, so this pattern was not triggered.Conclusion: The results suggested that as well as the brainstem respiration pacesetter, there was also a separate “pace signal” present which remained constant and seemed to define the respiration rate when at rest. It is currently unknown what mechanism causes the respiration rate to increase due to exercise. But these results suggest that the brainstem pacesetter is sometimes guided by the duodenal pace signal instead of the lung pace signal, which may explain how the pacesetter is able to jump to a higher rate, even though its chemoreceptor inputs may be unchanged.
The Cellular Pathways of Liver Fibrosis in NASH
Authors: Méndez-Sánchez Nahum , Coronel-Castillo Carlos Esteban , Contreras-Carmona Jocelyn , Barranco-Fragoso Beatriz , Qi Xingshun
Published: October 2019

Nonalcoholic steatohepatitis (NASH), which is characterized by liver steatosis, inflammation and fibrosis, is the most severe variation of nonalcoholic fatty liver disease (NAFLD). This disease is a consequence of several metabolic alterations such as type 2 diabetes and dyslipidemia that trigger different pathways of cell dysfunction and systemic inflammation which ultimately affect the liver. Furthermore, those mechanisms activate a complex cascade of immune response after repeated cell aggression. In the liver cytokines and interleukins interact with network of innate immune cells, including Kupffer cells (KCs), dendritic cells (DCs), lymphocytes and hepatic stellate cells (HSC). These cells translate those signals into immune responses and pathologic hepatic changes during the development of NASH. In this scenario the development of fibrosis is the most important change since it is an adaptive mechanism that in the short time has the objective of repair the damaged tissue but after prolonged injury it progresses to parenchymal scarring, cellular dysfunction and finally to organ failure. Finally, since NASH is an important cause of liver cirrhosis; this review addresses the cellular pathways of fibrosis in the setting of NASH explained by the interaction between immune and hepatic cells.
Military Training Areas as Semi Commons: The Territorial Valorization of Quirra (Sardinia) from Easements to Ecosystem Services
Authors: Balletto Ginevra , Milesi Alessandra , Fenu Nicolò , Borruso Giuseppe , Mundula Luigi
Published: October 2019

The military areas in Sardinia are around 234 km2, which constitutes 59.97% of the national surface affected by military easements. This situation is due to its geographic centrality in the Mediterranean. This contribution evaluates the performance of the Local Coastline Plan (LCP) and the Site Management Plan of Community Interest (SCI) in conditions of military constraint. The case study is the Municipality of Villaputzu where an important coastal military easement and the use of the coast for recreational tourism purposes coexist together through specific planning, a consequence of institutional agreements between the Municipal Administration of Villaputzu and the Ministry of Defense. The evaluation of the congruence of the specific objectives of the LCP and the SCI shows how their combined action favors the environmental enhancement of Sardinia, contributing to the formation of ecosystem services, even in particular conditions arising from military easements. These are sites that pass from the status of "anti-commons" to "semi-commons". In fact, the military release process in Sardinia, together with the promiscuous military and civil use, activates unique governance policies of their kind that find a significant field of application in Sardinia to guarantee a sustainable renewal of economic development of the ‘semi-commons’ awaiting to become ‘commons’
HUBUNGAN PARENTING SELF-EFFICACY DENGAN SUBJECTIVE WELL-BEING PADA IBU YANG MEMILIKI ANAK BERKEBUTUHAN KHUSUS
Authors: Hasanah Nidaul , Mulyati  , Tarma
Published: October 2019

Penelitian ini bertujuan untuk memperoleh gambaran mengenai hubungan parenting self-efficacy dengan subjective well-being pada ibu yang memiliki anak berkebutuhan khusus. Penelitian ini dilaksanakan di SLB Citra Mandala Bekasi. Metode penelitian ini menggunakan metode survei. Sampel pada penelitian ini berjumlah 63 responden ibu yang memiliki anak berkebutuhan khusus. Teknik pengambilan data menggunakan probability sampling yaitu disproportionate random sampling. Hasil pengujian hipotesis menggunakan uji-t dengan taraf signifikansi (p<0,05) diperoleh t_(hitung > ) t_(tabel ) yaitu sebesar 3,69 > 1,67. Hal ini menunjukkan bahwa terdapat hubungan yang signifikan antara parenting self-efficacy dengan subjective well-being. Berdasarkan hasil pengujian koefisien determinasi diperoleh hasil 18,22% dan hasil uji korelasi sebesar 0,427 yang berarti positif, sehingga dapat disimpulkan bahwa meningkatkanya parenting self-efficacy yang dirasakan ibu maka akan meningkatkan subjective well-being yang dirasakan.

Abstract

This research aim is conducted to obtain description about the relationship parenting self-efficacy with subjective well-being on mother’s special need children. This research was conducted in SLB Citra Mandala, East Bekasi. This research method using survey method. The population in this research is mother’s special need children at SLB Citra Mandala, East Bekasi with the total sample of 63 respondents. Data was taken by using disproportionate stratified random sampling. Result of correlation coefficient test are obtained rcount > r
Sargassum: the atypical irruption of an ancient ecosystem
Authors: Martínez-González Gustavo
Published: October 2019

El sargazo es un ecosistema marino milenario que circula en el sentido de las manecillas del reloj en el Océano Atlántico. A partir de 2011, el alga flotante que lo compone ha comenzado a recalar en playas de 19 países del Caribe, con consecuencias ambientales, sanitarias y económicas que deben atenderse con urgencia.
The Association between the Risk of Cardiovascular Disease and Androgen Deprivation Therapy in Patients with Prostate Cancer. A Meta-Analysis and systematic review.
Authors: Liang Zhen , Zhu Jun , Duo Xiaoxin , Shi Shangheng , Xu Yawei , Yang Yongjiao , Hu Rui , Lu Yi , Zhang Wei , Ou Ningjing , Song Yuxuan , An Neng , Chen Longlong , Liu Xiaoqiang
Published: October 2019

Background : Androgen deprivation therapy (ADT) is widely being applied in men who suffered from prostate cancer, our aim is to evaluate whether ADT is associated with an excess risk of cardiovascular disease (CVD).
Method : Studies comparing the the incidence of CVD between ADT group and control group were identified through literature search in electronic databases (Pubmed, Embase, Web of Science) until July 2019 and only observational studies and randomized controlled trials (RCT) were included. The estimating relative risk ratio (RR) and 95% confidence intervals (CI) were calculated through random effects meta-analyses.
Result : A statistically significant association was detected for acute myocardial infarction (AMI) with RR = 1.22; 95% confidence interval CI, 1.05–1.43; P< 0.05. Significant relationship between coronary heart disease (CHD) and ADT was also observed, with summary RR=1.19; 95%CI, 1.03-1.38; P<0.05. ADT was associated with a risk increasement for heart failure (HF) with RR=1.15; 95% CI 1.01–1.33; P< 0.05. On the contrary, ADT was not associated with an increased risk of sudden cardiac death (SCD).
Conclusions : From this study, ADT is associated with increased risk of AMI, CHD, and heart failure (HF); in contrast, this association is not detected in SCD; various modalities of ADT could significantly increase the risk of CHD, AMI, except for oral anti-androgen (AA). Our meta-analysis also suggests that the long-term application of ADT in prostate cancer patients would not result in a significant increase in AMI incidence compared with short-term. Moreover, the combined application of AA and GnRH agonists would lead to a similar risk of AMI compared with orchiectomy or GnRH agonists monotherapy whereas higher risk of CHD was detected when compared GnRH agonists plus AA with orchiectomy.
Association Between Early Childhood Caries And Malnutrition In A Sub-Urban Population In Nigeria
Authors: Folayan Morenike Oluwatoyin , Arije Olujide , Tantawi Maha El , Kolawole Kikelomo Adebanke , Obiyan Mary , Arowolo Olaniyi , Oziegbe Elizabeth O
Published: October 2019

Background : To determine the association between malnutrition and early childhood caries (ECC) in children resident in sub-urban, Nigeria.
Methods : This study is a secondary analysis of a larger cross-sectional data generated through a household survey. Variables (sex, frequency of sugar consumption, maternal knowledge of oral hygiene, oral hygiene status) associated with ECC in the primary study conducted in the Ile-Ife, Nigeria, were adjusted for in the models. We used Poisson regression analysis to determine the association between ECC and malnutrition (stunting, overweight and underweight). We reported the adjusted prevalence ratio (APR).
Results: Of the 370 children, 20 (5.41%) were underweight, 20 (5.41%) were overweight, 67 (18.11%) were wasting, 120 (32.43%) were stunted and 18 (4.86%) had ECC. Factors associated with ECC were being stunted, underweight, overweight and fair oral hygiene. The prevalence of ECC was lower in children who were stunted (APR: 0.14; 95% CI: 0.03-0.69; p=0.02), almost seven times higher in children who were overweight (APR: 6.88; 95% CI: 1.83-25.85; p<0.001), and predictively absent in children who were underweight (APR: 0; 95% CI: 0-0; p<0.001) when compared with children who had normal weight. Non-significant risk indicators for ECC included consuming sugar between meals three times a day or more, having low socioeconomic status and being female.
Conclusions : For this study population, the indicators of malnutrition – being stunted, underweight, overweight - and fair oral hygiene were risk indicators for ECC, while the frequency of sugar consumption was not a significant risk indicator. Further studies are needed to identify if there are other mediators of associations between ECC and nutrition status apart from sugar consumption.
Red blood cell distribution width and platelet counts are independent prognostic factors and improve the predictive ability of IPI score in diffuse large B-cell lymphoma patients
Authors: Li Manman , Xia Hailong , Zheng Huimin , Li Yafeng , Liu Jun , Hu Linhui , Li Jingrong , Ding Yangyang , Pu Lianfang , Gui Qianle , Zheng Yijie , Zhai Zhimin , xiong shudao
Published: October 2019

Background: Elevated red blood cell distribution width (RDW) and decreased platelet count (PLT) can be clinically relevant to the prognosis in cancer patients . However, their prognostic values in patients with diffuse large B-cell lymphoma (DLBCL) need to be further explored.
Methods: Healthy donors (n=130) and patients with DLBCL (n=349) were included and evaluated retrospectively in this study. The prognostic influence of clinical and pathological factors including RDW and PLT on overall survival (OS) and progression-free survival (PFS) were studied by Kaplan-Meier curves . To evaluate the independent prognostic relevance of RDW and PLT, univariate and multivariate Cox proportional hazards regression models were applied. The adjusted IPI model was established based on the results of multivariate analysis, and verified by Harrell's C statistical analysis.
Results: Kaplan-Meier curves indicated that an elevated RDW value and thrombocytopenia are poor factors for OS (P<0.001, P=0.006) and PFS (P=0.003, P<0.001) in DLBCL patients. Multivariate analysis confirmed that elevated RDW value (HR=2.026, 95%CI= 1.263-3.250, P=0.003) and decreased PLT count (HR =1.749, 95%CI=1.010-3.028, P=0.046) were both independent prognostic factors. The c-index of IPI and NCCN-IPI were increased when RDW level and PLT were supplemented in our cohort.
Conclusions: Our study shows that elevated RDW level and decreased PLT are independent poor prognostic factors in newly diagnosed DLBCL patients. Adding RDW and PLT to the IPI score may improve its predictive ability, and the adjusted IPI may be more powerful in predicting the survival of DLBCL patients in the rituximab era.
Keywords : prognosis, diffuse large B-cell lymphoma ( DLBCL ), red blood cell distribution width (RDW), platelet count (PLT)
The effectiveness of an interactive organ donation education intervention for Dutch lower-educated students: a cluster randomized controlled trial
Authors: Steenaart Esther , Crutzen Rik , Candel Math JJM , de Vries Nanne K
Published: October 2019

Background: Organ donation registration rates remain low, especially among people with lower educational levels. An interactive educational intervention was developed to prepare lower-educated students in the Netherlands for making a well-informed decision about organ donation. This article reports on the effects of this intervention on the intention to register (i.e. the primary outcome in the study at hand) and beliefs regarding organ donation.
Methods: The effectiveness was investigated in a post-test only cluster randomized controlled trial, in which the intervention was offered to the experimental group and after measurement also to the control group. Randomization to the experimental and control groups took place at a class level. Teachers of schools for intermediate vocational education who taught a course on Citizenship delivered three intervention elements (i.e. video fragments and discussion, quizzes with tailored feedback and exercise filling out a registration form) to their students during two 50-minute lessons.
Results: A total of 1170 students participated in the trial and filled out a questionnaire (45 experimental and 43 control classes). Compared to the control group, students in the experimental group had higher odds of having positive registration intentions (OR=1.81; 95%CI [1.10-2.96]), their perceived knowledge was higher (B=.62; 95%CI [.23-1.01]) and they had higher intentions to talk to family members (B=.68; 95%CI [.28-1.08]) and friends (B=.36; 95%CI [.07-.66]) about organ donation. There were no effects on the choice students intended to register (OR=1.08; 95%CI [.67-1.73]).
Conclusions: Providing education in a classroom setting is an effective tool in increasing registration intentions. Despite uncertainties about the effects on actual registration behavior, a larger scale dissemination of this intervention is recommended. Providing clear information and opening the discussion about organ donation is an important and promising first step towards higher registration rates.
Trial registration: The Dutch Trial Register, NTR6771. Registered on 24 October 2017. https://www.trialregister.nl/trial/6557
Plastome phylogenomics, biogeography, and clade diversification of Paris (Melanthiaceae)
Authors: Ji Yunheng , Yang Lifang , Chase Mark W. , Liu Changkun , Yang Zhenyan , Yang Jin , Yang Jun-Bo , Yi Ting-Shuang
Published: October 2019

Background: Paris (Melanthiaceae) is an economically important but taxonomically difficult genus, which is unique in angiosperms because some species have extremely large nuclear genomes. Phylogenetic relationships within Paris have long been controversial. Based on complete plastomes and nuclear ribosomal DNA (nrDNA) sequences, this study aims to reconstruct a robust phylogenetic tree and explore historical biogeography and clade diversification in the genus.Results: All 29 species currently recognized in Paris were sampled. Whole plastomes and nrDNA sequences were generated by the genome skimming approach. Phylogenetic relationships were reconstructed using the maximum likelihood and Bayesian inference methods. Based on the phylogenetic framework and molecular dating, biogeographic scenarios and historical diversification of Paris were explored. Significant conflicts between plastid and nuclear datasets were identified, and the plastome tree is highly congruent with past interpretations of the morphology. Ancestral area reconstruction indicated that Paris may have originated in northeastern Asia and northern China, and has experienced multiple dispersal and vicariance events during its diversification. The rate of clade diversification has sharply accelerated since the Miocene/Pliocene boundary.Conclusions: Our results provide important insights for clarifying some of the long-standing taxonomic debates in Paris. Cytonuclear discordance may have been caused by ancient and recent hybridizations in the genus. The climatic and geological changes since the late Miocene, such as the intensification of Asian monsoon and the rapid uplift of Qinghai-Tibet Plateau, as well as the climatic fluctuations during the Pleistocene, played essential roles in driving range expansion and radiative diversification in Paris. Our findings challenge the theoretical prediction that large genome sizes may limit speciation.
Differential expression of IDA (INFLORESCENCE DEFICIENT IN ABSCISSION)-like genes in Nicotiana benthamiana during corolla abscission, stem growth and water stress
Authors: Ventimilla Daniel , Domingo Concha , Gonzalez-Ibeas Daniel , Talon Manuel , Tadeo Francisco R.
Published: October 2019

Background
IDA (INFLORESCENCE DEFICIENT IN ABSCISSION)-like signaling peptides and the associated HAE (HAESA)-like family of receptor kinases were originally reported in the model plant Arabidopsis thaliana (Arabidopsis) to be deeply involved in the regulation of abscission. Actually, IDA peptides, as cell-to-cell communication elements, appear to be implicated in many developmental processes that rely on cell separation events, and even in the responses to abiotic stresses. However, the knowledge related to the molecular machinery regulating abscission in economically important crops is scarce. In this work, we determined the conservation and phylogeny of the IDA -like and HAE -like gene families in relevant species of the Solanaceae family and analyzed the expression of these genes in the allopolyploid Nicotiana benthamiana, in order to identify members involved in abscission, stem growth and in the response to drought conditions.
Results
The phylogenetic relationships among the IDA -like members of the Solanaceae studied, grouped the two pairs of NbenIDA1 and NbenIDA2 protein homeologs with the Arabidopsis prepropeptides related to abscission. Analysis of promoter regions searching for regulatory elements showed that these two pairs of homeologs contained both hormonal and drought response elements, although NbenIDA2A lacked the hormonal regulatory elements. Expression analyses showed that the pair of NbenIDA1 homeologs were upregulated during corolla abscission. NbenIDA1 and NbenIDA2 pairs showed tissue differential expression under water stress conditions, since NbenIDA1 homeologs were highly expressed in stressed leaves while NbenIDA2 homeologs, especially NbenIDA2B , were highly expressed in stressed roots. In non-stressed active growing plants, nodes and internodes were the tissues with the highest expression levels of all members of the IDA -like family and their putative HAE -like receptors.
Conclusion
Our results suggest that the pair of NbenIDA1 homeologs are involved in the natural process of corolla abscission while both pairs of NbenIDA1 and NbenIDA2 homeologs are implicated in the response to water stress. The data also suggest that IDA peptides may be important during stem growth and development. These results provide additional evidence that the functional module formed by IDA peptides and its receptor kinases, as defined in Arabidopsis, may also be conserved in Solanaceae.
Elevated expression of AGGF1 predicts poor prognosis and promotes the metastasis of colorectal cancer
Authors: Zhang Xin , Sun Huimin , Chen Wanyuan , He Xianglei
Published: October 2019

Abstract
Background: Angiogenic factor with G-patch and FHA domains 1 (AGGF1) can promote angiogenesis and increasing evidence has highlighted the important roles of AGGF1 in tumorigenesis. However, the expression patterns as well as the biological functions of AGGF1 in colorectal cancer (CRC) remain to be established. The purpose of the present study is therefore to identify the effect of AGGF1 on prognosis and metastasis in CRC patients.
Methods: The expression level of AGGF1 in CRC was examined by qPCR, western blot and immunohistochemistry in a tissue microarray containing 101 CRC specimens. And the effect of AGGF1 on CRC cell malignance was investigated in our established stable AGGF1 upregulated and knockdown CRC cell lines.
Results: The expression level of AGGF1 in CRC tissue was not significantly different to that in adjacent normal mucosa at the mRNA level. However, at the protein level, AGGF1 expression in CRC tissues was significantly higher than in paired normal mucosa, which showed a clear association with TNM stage, AJCC stage, vascular invasion, and differentiation. Further, we revealed an apparent correlation between AGGF1 expression and poorer disease-free survival and overall survival of CRC patients. In addition, we discovered that AGGF1 significantly promoted CRC cell wound healing, migration, and invasion in vitro and distant metastasis in vivo .
Conclusions: Our study demonstrates the aberrant expression of AGGF1 in CRC and provides a basis on which to explore the application of AGGF1 as a novel prognostic biomarker for CRC patients, especially for CRC patients with distant metastasis.
Association of uncoordinated sucking pattern with developmental outcome in premature infants: a retrospective analysis
Authors: Yi You Gyoung , Oh Byung-Mo , Shin Seung Han , Shin Jin Yong , Kim Ee-Kyung , Shin Hyung-Ik
Published: October 2019

Background
Stress signals during sucking activity such as nasal flaring, head turning, and extraneous movements of the body have been attributed to incoordination of sucking, swallowing, and respiration (SSR) in premature infants. However, the association of uncoordinated sucking pattern with developmental outcomes has not yet been investigated. The aim of this study was to investigate whether uncoordinated sucking pattern during bottle-feeding in premature infants is associated with the developmental outcomes at 8-12 and 18-24 months of age (corrected for prematurity).
Methods
We retrospectively reviewed the medical records and video recordings for the Neonatal Oral-Motor Assessment Scale (NOMAS) of premature infants and divided them into two groups based on the presence or absence of incoordination. The Bayley-III cognition composite scores of the incoordination-positive and incoordination-negative group were compared at 8-12 and 18-24 months of age.
Results
Seventy premature infants exhibited a disorganized sucking pattern according to the NOMAS. The average Bayley-III cognition composite scores at 8-12 months of age were 92.5±15.6 and 103.0±11.3 for the incoordination-positive (n=22) and incoordination-negative groups (n=48), respectively (p=0.002). The average Bayley-III cognition composite scores at 18-24 months were 90.0±17.9 and 100.7±11.5 for the incoordination-positive (n=21) and incoordination-negative groups (n=46), respectively (p=0.005). A multiple linear regression analysis indicated that the presence of uncoordinated sucking pattern, grade 3 or 4 germinal matrix hemorrhage–intraventricular hemorrhage, and moderate to severe bronchopulmonary dysplasia were independently associated with cognitive development at 18-24 months of age.
Conclusions
Uncoordinated sucking pattern in premature infants was independently associated with a higher risk of abnormal developmental outcome in the cognitive domain of the Bayley-III at both 8-12 and 18-24 months. There may be a need for periodic follow-up and early intervention for developmental delay when incoordination of SSR that results in stress signals on the NOMAS is observed before 40 weeks postmenstrual age.
Creatine kinase elevation after robotic surgery for rectal cancer due to a prolonged lithotomy position
Authors: Tsuchiya Yuki , Munakata Shinya , Tsukamoto Ryoichi , Okazawa Yu , Mizukoshi Kosuke , Sugimoto Kiichi , Takahashi Makoto , Kojima Yutaka , Tomiki Yuichi , Sakamoto Kazuhiro
Published: October 2019

Background Robotic surgery for rectal cancer, which is now performed worldwide, can be associated with elevated creatine kina se levels postoperatively. In this study, we compared postoperative complications between patient undergoing robotic surgery and laparoscopic surgery. Methods We identified 66 consecutive patients who underwent curative resection for rectal cancer at Juntendo University Hospital between January 2016 and February 2019. Patients were divided into a conventional laparoscopic surgery (CLS) group (n = 38) and a robotic-assisted laparoscopic surgery (RALS) group (n = 28) before comparing various clinicodemographic factors between the groups. Results Patient age and gender, surgical approach (CLS/RALS), pathological T factor, pathological stage, duration of postoperative hospital stay, and postoperative complications were not significantly different between the RALS and CLS groups. However, the operation time was significantly longer in the RALS group (407 min) than in the CLS group ( 295 min; p < 0.001 ). Notably, the serum level of creatine kinase on postoperative day 1 was significantly higher in the CLS group (154 IU/L) than in the RALS group (525 IU/L; p < 0.001), despite there being no significant differences in the incidence of rhabdomyolysis. Conclusions Clinically relevant positioning injuries and rhabdomyolysis may occur in patients who are subjected to a prolonged and extreme Trendelenburg position or who have extra force applied to the abdominal wall because of remote center displacement. The creatine kinase value should therefore be measured after RALS to monitor for the sequelae of these potential positioning injuries.
Binding modes of potential anti-prion phytochemicals to PrPC structures in silico
Authors: Neupane Sandesh , Khadka Jenisha , Rayamajhi Sandesh , Pandey Arti S.
Published: October 2019

Background: Prion diseases involve the conversion of a normal, cell-surface glycoprotein (PrPC ) into a misfolded pathogenic form (PrPSC ). Cellular assays and in vivo experiments have identified various compounds with anti-prion activity which work through various mechanisms. Structures of PrPC have revealed the protein to occur in a swapped or non-swapped, monomeric or dimeric forms. Binding modes of known anti-prions is either not known, or has been determined with only the non-swapped structures of PrPC . In the current study medicinal phytochemicals from various databases have been docked with PrPC in silico to identify potential anti-prions in comparison with known anti-prion compounds to determine their binding modes and speculate possible mechanisms of inhibition of PrPC to PrPSC . Results: Eleven new phytochemicals were identified based on their binding energies and pharmacokinetic properties. The binding sites and interactions of the known and new anti-prion compounds are similar, and differences in binding modes occur in structures with very subtle differences in side chain conformations. Binding of these compounds poses steric hindrance to neighbouring molecules. Residues shown to be associated with inhibition of PrPC to PrPSC conversion form interactions with most of the compounds. Conclusions: The new compounds are mostly highly hydrophobic and are derivatives of terpenes, sterols and quinones. They might act as potent inhibitors of the PrPC to PrPSC conversion through a combination of steric hindrance and stabilization of structure through ionic/hydrophobic interactions. Their high binding energies coupled with identical binding sites as those of the known compounds, and their ability to cross the blood brain barrier makes these phytochemicals a promising group of compounds for further studies on prevention of PrPC to PrPSC .
Effect Of Maternal Growth Monitoring Knowledge On Stunting, Wasting And Underweight Among Children 0-18 Months In Tamale Metropolis Of Ghana
Authors: Bukari Mohammed , Abubakari Muzamil Mohammed , Majeed Mohammed , Abizari Abdul-Razak , Wemakor Anthony , Atosona Ambrose
Published: October 2019

Objective: This study sought to assess maternal growth monitoring knowledge and its effect on stunting, wasting and underweight among children 0-18 months in the Tamale Metropolis.An analytical cross-sectional study design, involving 340 mother-child pairs randomly selected from 4 health facilities in the Tamale Metropolis, was used. A structured questionnaire was used to collect information on socio-demographic characteristics and maternal growth monitoring knowledge. Weight and length of children were taken to assess nutritional status (stunting, underweight and wasting). Logistic regression analysis was used to determine the association between maternal growth monitoring knowledge level and child nutritional status. Results: The study revealed that 87.6% of mothers had good knowledge on growth monitoring. The prevalence of stunting, underweight and wasting were 9.4%, 25.9% and 17.9% respectively. A binary logistic regression analysis revealed that there is no association between maternal growth monitoring knowledge and stunting [Adjusted Odds Ratio (AOR) = 0.593; 95% Confidence Interval (CI): 0.170-2.067], underweight (AOR= 1.56; 95% CI: 0.697-3.612) and wasting (OR= 0.881; 95% CI: 0.414-1.876) among children 0-18 months in the Tamale Metropolis.