bluuebunny/crossref_metadata_2025 huggingface dataset:
Mass Spectrometry Imaging-Based Single-Cell Lipidomics Profiles Metabolic Signatures of Heart Failure
Authors: Ren Jie , Li Hao-Wen , Chen Liang , Zhang Min , Liu Yan-Xiang , Zhang Bo-Wen , Xu Rui , Miao Yan-Yan , Xu Xue-Mei , Hua Xin , Sun Xiao-Gang , Yu Ru-Jia , Long Yi-Tao , Hu Sheng-Shou
Published: January 2023

Heart failure (HF), leading as one of the main causes of mortality, has become a serious public health issue with high prevalence around the world. Single cardiomyocyte (CM) metabolomics promises to revolutionize the understanding of HF pathogenesis since the metabolic remodeling in the human hearts plays a vital role in the disease progression. Unfortunately, current metabolic analysis is often limited by the dynamic features of metabolites and the critical needs for high-quality isolated CMs. Here, high-quality CMs were directly isolated from transgenic HF mice biopsies and further employed in the cellular metabolic analysis. The lipids landscape in individual CMs was profiled with a delayed extraction mode in time-of-flight secondary ion mass spectrometry. Specific metabolic signatures were identified to distinguish HF CMs from the control subjects, presenting as possible single-cell biomarkers. The spatial distributions of these signatures were imaged in single cells, and those were further found to be strongly associated with lipoprotein metabolism, transmembrane transport, and signal transduction. Taken together, we systematically studied the lipid metabolism of single CMs with a mass spectrometry imaging method, which directly benefited the identification of HF-associated signatures and a deeper understanding of HF-related metabolic pathways.
3D-Printed Janus Piezoelectric Patches for Sonodynamic Bacteria Elimination and Wound Healing
Authors: Huang Danqing , Cheng Yi , Chen Guopu , Zhao Yuanjin
Published: January 2023

Management of infected wounds has raised worldwide concerns. Attempts in this field focus on the development of intelligent patches for improving the wound healing. Here, inspired by the cocktail treatment and combinational therapy stratagem, we present a novel Janus piezoelectric hydrogel patch via 3-dimensional printing for sonodynamic bacteria elimination and wound healing. The top layer of the printed patch was poly(ethylene glycol) diacrylate hydrogel with gold-nanoparticle-decorated tetragonal barium titanate encapsulation, which realizes the ultrasound-triggered release of reactive oxygen species without leaking nanomaterials. The bottom layer is fabricated with methacrylate gelatin and carries growth factors for the cell proliferation and tissue reconstruction. Based on these features, we have demonstrated in vivo that the Janus piezoelectric hydrogel patch can exert substantial infection elimination activity under the excitation of ultrasound, and its sustained release of growth factors can promote tissue regeneration during wound management. These results indicated that the proposed Janus piezoelectric hydrogel patch had practical significance in sonodynamic infection alleviation and programmable wound healing for treating different clinical diseases.
Furan Donor for NIR-II Molecular Fluorophores with Enhanced Bioimaging Performance
Authors: Liu Chunchen , Li Mengfei , Ma Huilong , Hu Zhubin , Wang Xinyuan , Ma Rui , Jiang Yingying , Sun Haitao , Zhu Shoujun , Liang Yongye
Published: January 2023

The second near-infrared (NIR-II, 1,000 to 1,700 nm) molecular fluorophores containing donor–acceptor–donor conjugated backbone have attracted substantial attention due to their outstanding advantages, such as stable emission and facilely tuned photophysical properties. However, it is still challenging for them to simultaneously achieve high brightness and red-shifted absorption and emission. Herein, furan is adopted as the D unit to construct NIR-II fluorophores, demonstrating red shift of absorption, enhanced absorption coefficient, and fluorescent quantum yield when compared with the generally used thiophene counterparts. The high brightness and desirable pharmacokinetics of the optimized fluorophore, IR-FFCHP, endows improved performance for angiography and tumor-targeting imaging. Furthermore, dual-NIR-II imaging of tumor and sentinel lymph nodes (LNs) has been achieved with IR-FFCHP and PbS/CdS quantum dots, enabling the in vivo imaging navigated LN surgery in tumor-bearing mice. This work demonstrates the potential of furan for constructing bright NIR-II fluorophores for biological imaging.
Efficient Modulation of Exon Skipping via Antisense Circular RNAs
Authors: Ren Shuaiwei , Huang Mei , Bai Raoxian , Chen Lijiao , Yang Jiao , Zhang Junyu , Guo Wenting , Ji Weizhi , Chen Yongchang
Published: January 2023

Splice-switching antisense oligonucleotides (ASOs) and engineered U7 small nuclear ribonucleoprotein (U7 Sm OPT) are the most commonly used methods for exon skipping. However, challenges remain, such as limited organ delivery and repeated dosing for ASOs and unknown risks of by-products produced by U7 Sm OPT. Here, we showed that antisense circular RNAs (AS-circRNAs) can effectively mediate exon skipping in both minigene and endogenous transcripts. We also showed a relatively higher exon skipping efficiency at the tested
Dmd
minigene than U7 Sm OPT. AS-circRNA specifically targets the precursor mRNA splicing without off-target effects. Moreover, AS-circRNAs with adeno-associated virus (AAV) delivery corrected the open reading frame and restored the dystrophin expression in a mouse model of Duchenne muscular dystrophy. In conclusion, we develop an alternative method for regulating RNA splicing, which might be served as a novel tool for genetic disease treatment.
Gamma-ray Vortex Burst in Nonlinear Thomson Scattering with Refocusing Spiral Plasma Mirror
Authors: Zhou Weijun , Yan Wenchao , Wang Jinguang , Chen Liming
Published: January 2023

The gamma-ray vortex burst in the nonlinear Thomson scattering when the laser wakefield accelerated electron bunch collides with an ultra-intense Laguerre–Gaussian laser that was reflected from the refocusing spiral plasma mirror. The orbit angular momentum of the scattering laser would be transferred to the gamma radiation through the scattering process. The 3-dimensional particle-in-cell simulations gave the electron dynamics in the scattering, which determines the characteristics of the vortical radiation. The radiation calculation results illustrated the burst of gamma-ray vortex and surprisingly revealed the radiation pattern distortion phenomenon due to the nonlinear effect. This scheme can not only simplify the experimental setup for the generation of twisted radiation but also boost the yield of vortical gamma photons. The peak brightness of the gamma-ray vortex was estimated to be 1 × 10
22
photons/s/mm
2
/mrad
2
/0.1% BW at 1 MeV, which might pave the way for the researches on angular momentum-related nuclear physics.
ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG VÀ KẾT QUẢ ĐIỀU TRỊ HỘI CHỨNG THẬN HƯ KHÁNG CORTICOSTEROID Ở TRẺ EM TẠI BỆNH VIỆN SẢN NHI BẮC NINH
Authors: Hiếu Nguyễn Thị , Hiệp Nguyễn Minh , Hương Nguyễn Thị Xuân
Published: January 2023

Nghiên cứu mô tả đặc điểm lâm sàng, cận lâm sàng và phân tích kết quả điều trị trẻ mắc hội chứng thận hư tiên phát kháng Corticosteroid. Nhóm tác giả thực hiện mô tả tiến cứu trên 37 trẻ mắc hội chứng thận hư tiên phát kháng Corticosteroid ở trẻ em tại Bệnh viện Sản Nhi Bắc Ninh từ tháng 01/2021- 12/2021. Kết quả nghiên cứu có 27/37 (73%) nam, 10/37 (27%) nữ, tỷ lệ nam/nữ: 2,7/1, tuổi trung bình 10,1±3,3 tuổi. Lâm sàng: 54,1% (20/37) hội chứng thận hư thể đơn thuần, 94,6% (35/37) hội chứng thận hư tiên phát, 100% có phù ở các mức độ, trong đó 27,1% (10/37) phù nặng, 6/37 (16,2%) tăng huyết áp. Cận lâm sàng: 28/37 (75,7%) tăng số lượng bạch cầu, 100% giảm albumin máu, 36/37 (97,3%) giảm protein máu, 02/37 (5,4%) thiếu máu và tăng ure máu, 01/37 (2,7%) tăng creatinin mức độ nhẹ. Kết quả điều trị mức độ phù giảm dần qua thời gian điều trị, sau 6 tháng, 12 tháng tỷ lệ không phù đã tăng nhanh (đều trên 90%). Thời gian trung bình protein niệu trở về âm tính là 1,76 ± 0,99 tháng. Có sự giảm dần số lượng bạch cầu trở về giới hạn bình thường qua thời gian điều trị và có sự giảm lượng urea máu có ý nghĩa thời điểm sau 12 tháng điều trị so với sau 6 tháng (p<0,05), tỷ lệ kết quả điều trị chung 21/37 (56,8%) tốt. Biểu hiện lâm sàng, cận lâm sàng của bệnh nhi mắc hội chứng thận hư kháng Corticosteroid nặng nề, kết quả điều trị chung chưa cao.
NGHIÊN CỨU ĐỀ XUẤT MÔ HÌNH KINH TẾ TUẦN HOÀN QUẢN LÝ CHẤT THẢI RẮN SINH HOẠT HỘ GIA ĐÌNH TẠI THÀNH PHỐ BẮC NINH
Authors: Mỵ Nguyễn Thị , Ý Nguyễn Như , Thu Hà Dương Thị , Sơn Cao Trường
Published: January 2023

Nghiên cứu này được thực nhằm đề xuất mô hình kinh tế tuần hoàn  quản lý chất thải rắn sinh hoạt tại hộ gia đình cho thành phố Bắc Ninh. Chúng tôi đã tiến hành thiết kế phiếu điều tra để điều tra các hộ gia đình, cán bộ quản lý chất thải rắn sinh hoạt; điều tra khảo sát hoạt động thu gom, vận chuyển và xử lý chất thải rắn sinh hoạt; lấy mẫu rác để xác định khối lượng, thành phần chất thải rắn sinh hoạt. Kết quả nghiên cứu cho thấy khối lượng chất thải rắn sinh hoạt phát sinh bình quân của các hộ gia đình trên địa bàn thành phố Bắc Ninh là 0,65 kg/người/ngày, tổng lượng phát sinh vào khoảng 169 tấn/ngày (gần 62 nghìn tấn/năm). Trong đó, có tới 94,4% khối lượng chất thải rắn sinh hoạt có khả năng tuần hoàn, tái sử dụng gồm: 21,74% rác có khả năng tái chế và 72,66% rác hữu cơ dễ phân hủy. Mô hình kinh tế tuần hoàn quản lý chất thải rắn sinh hoạt tại cấp độ hộ và cấp độ thành phố đã được đề xuất cho thành phố Bắc Ninh. Việc chuyển đổi từ mô hình quản lý chất thải rắn sinh hoạt theo phương thức cũ (thu gom – vận chuyển – xử lý) sang mô hình kinh tế tuần hoàn quản lý chất thải rắn sinh hoạt là xu hướng chung của Việt Nam và thế giới, góp phần tiết kiệm tài nguyên, giảm thiểu chi phí xử lý và bảo vệ môi trường.
Implementation of Driver Software of Trailer Module Chip
Authors: C Sundar Ganesh , T Vinoth Kumar , B Gopinath , C Madhan Kumar , B Suresh , M Vijayaragavan
Published: January 2023

The aim of the project is to develop a driver software for UJA1076A SBC in embedded C using IAR Embedded Workbench and integrate the driver software with application software of Trailer module. Currently MC33903 system basis chip from Freescale is used in Trailer Module. As an initiative to reduce the material cost for the Trailer module product, a lower price SBC NXP UJA1076A has been used. Also due to the fact that the newly proposed SBC has less number of operating modes and registers to configure, it helps in making the driver software much more simpler, thus reducing the risk of hidden issues in the otherwise complex design and code of the current SBC driver software.
Body Composition Assessment of University Athletes: Comparison Between the Data Obtained by Bioelectrical Impedance and by Anthropometry
Authors: Abreu Bruno , Henriques Rafael , Figueiredo João Paulo , Loureiro Helena
Published: January 2023

Introduction: To compare the values obtained of the most used practical methods in clinical practice, by bioelectrical impedance and by anthropometry of the body composition of university athletes. Methods: Observational analytical study whose sample included 26 athletes of a Portuguese university football team. The assessment of individuals’ body composition was executed through bioelectrical impedance and anthropometry by an ISAK level one anthropometrist accredited completing the inherent protocol. For the data analysis was considered a critical significance level of 5% for a confidence level of 95% to test the hypotheses between the variables under study and their correlations, Pearson's parametric test of linear correlation coefficient was applied. Results: The variability of body composition assessed in the sample is highlighted. Significant correlations were found for fat mass and skinfolds sum (r=0,782; p=<0,001) as well as for individual skinfolds. Respectively through the elaboration of the scatter diagram, the following linear r2= 0.612 was obtained, representing the correlation between the variables. Similar correlations were found in the context of fat free mass and circumferences. However, in the case of the waist-to-hip ratio assessed by electrical bioimpedance and the waist-to-hip ratio assessed by anthropometry, there were lower correlations compared to the other parameters evaluated (r=0,441; p=0,036). Conclusion: It is intended to make it easier for interested sports professionals to select practical methods for assessing the body composition of their athletes, while eliminating the risk of selecting inappropriate methods. It is noted the possibility of replacing or complementing the bioelectrical impedance analysis with an accessible and viable anthropometric method such as the skinfolds sum, especially in teams with lower budgets like the university teams.
Support Vector Classification with Hyperparameters for Analysis of Public Sentiment on Data Security in Indonesia
Authors: Ernawati Siti , Wati Risa , Nuris Nuzuliarini
Published: January 2023

The development of Information Technology makes increasing use of the internet. This raises the vulnerability of data security. Cyber attacks in Indonesia caused many tweets on social media Twitter. Some are positive, and some are negative. The problem of this study is to determine the public sentiment towards data security in Indonesia, while the purpose of this study is how the response or evaluation of the government of Indonesia to the many perceptions of people who lack confidence in data security in Indonesia. Data obtained from twitter with as much as 706 data was processed using python with a percentage of 10% test data and 90% training data. Weighting is done using TF-IDF, and then the Data is processed using the Support Vector Machine algorithm using the SVC (Support Vector Classification) library. Support Vector Classification with RBF kernel classifies Text well to obtain AUC value with good classification category. Utilizing one of the hyperparameter techniques, which is a grid search technique that can compare the accuracy of test results. The test results using SVC with RBF kernel obtained an accuracy value of 0.87, Precision of 0.82, recall of 0.94, and F1_Score of 0.87. This study is expected to be used by decision-makers related to public confidence in data security in Indonesia
A Study on the Implications of McLuhan’s Media Theory for Metaverse Education
Authors:   Korean Society for  Holistic Convergence Education, Kim Chang Hwan
Published: January 2023

This paper examines the metaverse and metaverse education from the perspective of McLuhans‘ media Theory. This paper consists of three parts: “McLuhan’s media theory and education”, “metaverse and education”, and “metaverse education in the light of McLuhan‘s future education”. As a result of the study, it was found that the paradigm shifting characteristics of the metaverse, that is, “participation”, “holistic character”, “diversity”, and “scalability”, showed a direction similar to McLuhan's future education paradigm. In addition, the paradigm of future education predicted by McLuhan in metaverse education, that is, “place of education”, “purpose of education”, “teaching-learning relationship”, “characteristic of education”, “image of teachers and students” showed almost the same structure as that of McLuhan. Finally, it was discovered that the metaverse is a new medium that can overcome the education of the print media era and bring about a paradigm shift. In conclusion, this paper emphasized that our perspective on metaverse education should be changed from ‘How to use the Metaverse platform for the education’ to ‘How to create the Metaverse platform itself educationally’.
Páginas Republicanas
Authors: Pereira dos Santos Carlos Augusto
Published: January 2023

Organizar um livro é sempre uma possibilidade de se reunir artigos em torno de um tema comum. A historiografia brasileira é fecunda em exemplos de esforços dessa natureza, onde grandes projetos editoriais são organizados não somente para dar um balanço das pesquisas desenvolvidas por vários pesquisadores sobre temáticas diversas, não somente de caráter revisionista, mas também, uma oportunidade de se agregar múltiplas sínteses visando ampliar o público leitor num esforço de popularização da História, no bom sentido do termo, notadamente entre professores e estudantes do ensino médio. […] Daqui da nossa tribuna, sempre que chegamos ao oitavo período do curso de História, ministramos a disciplina de História do Brasil III (República) e procuramos saber que assuntos e temáticas os alunos estão desenvolvendo como Trabalhos de Conclusão de Curso (TCC’s). Na grande maioria dos casos, os objetos de estudo têm um pé no período republicano, temporal e espacialmente, e enfocando temas relativos à história local. […] Deste modo, os trabalhos desta obra coletiva, em sua multiplicidade e variedade, foram agrupados em cinco marcos cronológicos da história republicana já consolidados na historiografia brasileira.
Learning with Low Tech: Challenges of Moving to Remote Learning in a Time of Disruption
Authors: Krull Greig
Published: January 2023

This is a preprint of the following chapter: G.E. Krull, Learning with low tech: Challenges of moving to remote learning in a time of disruption, published in Pedagogical Responsiveness in Complex Contexts: Issues of Transformation, Inclusion and Equity, edited by E. Walton & R. Osman, 2022, Springer Nature, reproduced with permission of Springer Nature. The final authenticated version is available online at: https://doi.org/10.1007/978-3-031-12718-2 ABSTRACT: Due to the international disruptions associated with the public health emergency (Covid-19 pandemic) in 2020, universities faced a period of unprecedented disruption. While dealing with health concerns for staff and students as well as national lockdowns and social distancing restrictions, universities had to decide whether and how to continue teaching and learning. Many universities in South Africa decided to continue their academic programmes by devising emergency plans for remote teaching and learning. This had a significant impact on both staff and students at contact universities. However, socio-economic issues compounded the challenge of remote learning, with some students forced to study at home in less than ideal conditions, without access to typical campus resources. Broader issues such as health concerns, power outages and family responsibilities also affected the continuity of teaching and learning. In the South African context, affordable access to quality internet and devices suitable for learning remains a considerable challenge. The aim of this chapter is to consider the pedagogical responsiveness of a South African university to the complex context caused by the global Covid-19 pandemic, with a particular focus on local contextual and technological accessibility challenges. This chapter reviews the adoption of teaching with low bandwidth (or low-tech) strategies to overcome technological accessibility challenges in this complex educational context. It then analyses the impact and effects on students who had to quickly transition to a completely new way of learning during a period of great uncertainty.
ANALYSIS OF THE MOTIVATION LEVEL OF CONSTRUCTION PROJECT WORKERS DURING THE COVID-19 PANDEMIC BASED ON MASLOW'S THEORY USING THE BAYESIAN BELIEF NETWORK METHOD
Authors: Mirnayani  , Kholida Lily
Published: January 2023

Labor productivity is a very important factor in construction because it will affect the successful implementation of construction projects, therefore a decrease in worker productivity is highly avoided. The emergence of the Covid-19 pandemic has made changes in the implementation of construction due to the new policies that apply. The Jakarta International Stadium project experienced problems in terms of manpower during the Covid-19 pandemic, including a reduction in manpower and working hours due to restrictions on the number of workers. However, the project still has a target completion time so that there will be no longer delays. These demands affect the motivation of workers, which will then affect their productivity. This study uses a quantitative approach with the Bayesian Belief Network (BBN), to determine the magnitude of motivation during the pandemic based on the dominant variables that influence it. Based on the results of the study, the dominant variables of the five need factors based on Maslow's Theory that affect motivation are the provision of supplements to workers, health checks before work, good relations between workers, good work direction, family support, training program procurement, and decision making. The amount of motivation for the Jakarta International Stadium construction project workers during the Covid-19 pandemic was 72.90. Strategies to increase the motivation of construction project workers during the Covid-19 pandemic include providing supplements, increasing the number of health check officers, workers can interact with families virtually, training, and providing independent understanding and direction in making decisions at work.
Evaluation Of Implementation Construction Safety Management Systems Of Toll Road Infrastructure Construction Project During Pandemic Covid-19 In Indonesia
Authors: Machfudiyanto Rossy Armyn , Mubarok Ida Sahli
Published: January 2023

The high level of development is directly proportional to the probability of accidents that may occur. In Indonesia, work accidents in the construction sector still often happened. Based on data from DataIndonesia.id, since 2017-2021 work accidents always increase every year, where in 2017 there were 123,040 accidents and in 2021 it reached 234,270 accidents with an average increase of 18% per year. This study aims to evaluate the implementation of the construction safety management system for toll road infrastructure project refers to the Minister of Public Works and Public Housing Regulation Number 10 of 2021 concerning Guidelines for Construction Safety Management Systems. This research applied a case study method-based with indepth interview and questionnaire techniques which were reviewed by descriptive analysis and statistical tests. The results of this study indicate that the implementation of the construction safety management system on the ABC Toll Road project is in the satisfactory category. There are several indicators whose implementation is not in accordance with the PUPR Ministerial Regulation Number 10 of 2021 due to the lack of insight or knowledge regarding the SMKK implementation program. The formulation of a recommendation strategy for improving the implementation of SMKK can be done by 1) Providing education, training, and/or counseling related to SMKK 2) Compiling SMKK documents in accordance with applicable regulations 3) Strengthening SMKK inspection programs and safety patrols 4) Documenting SMKK implementation activities 5) Procurement of activities such as safety morning talk and Toolbox meeting and procurement of facilities such as K2 information boards 6) Conduct safety meeting with MP regarding construction safety policies and explain to all project stakeholders 7) Provide awards or incentives if construction safety is achieved and 8) Conduct studies more in depth related to SMKK regulations.
Pelatihan Cara Penanaman Tanaman Obat Keluarga (Toga) Bersama (KWT) dan (PKK) di Desa Karya Maju A1
Authors: Dhony Nugroho Notosutanto Arhon , Khotimah Dea Husnul , Agustin Alvini , Lesiana Novi , Rafelinda Vira , Irawan Bayu
Published: January 2023

Family Medicinal Plants (TOGA) are plants that are used to describe maintenance and cultivation reports that are used as treatment. The training was carried out in Karya Maju A1 Village, which is a village in Keluang District, Musi Banyuasin Regency, whose main livelihoods are gardening and farming. TOGA is a herbal plant for medicines, for example, lime, turmeric, betel, brotowali and others. other. Therefore, holding training on how to plant family medicinal plants (TOGA), carried out and directed by Students of the PGRI Palembang University Real Work Lecture (KKN) to improve the skills and creativity of the Karya Maju A1 village community, Members of the Women Farmers Group (KWT), members (PKK). The method used is how to cultivate family medicinal plants using lecture, discussion, and question and answer methods. The aim of this training is to find out how the Training on How to Grow Medicinal Plants in the Family (TOGA) is carried out.
Helicobacter Pylori Infection among Children with Recurrent Abdominal Pain: A Single Center Study
Authors: Hasan Dr. Md. Kamrul , Ahmed Dr. Syed Shafi , Mahmud Dr. Salauddin , Ratan Dr. Md. Naim Hossain , Hasan Dr. Nazmul , Halder Dr. Kanta , Farid Dr. Md. Shakh , Tisha Dr. Shahrina Afroze , Islam Dr. Saiful
Published: January 2023

Background: Recurrent abdominal pain (RAP) is a common problem in children. Mostly it is functional, but due to recent advanced diagnostic technologies more organic causes are identifying. Among the organic causes Helicobacter pylori (H. pylori) infection is common, especially in developing countries. Early detection and treatment of this infection may prevent some serious gastrointestinal problems in later age. Objective: To evaluate the frequency of H. pylori infection as a cause of recurrent abdominal pain in children. Methods: This cross sectional study was conducted among the children with recurrent abdominal pain (RAP) in the pediatric Gastroenterology, Hepatology & Nutrition Department of Bangladesh Shishu Hospital & Institute in Bangladesh from January 2019 to December 2020. A total of 70 patients were included in the study. Demographic data, clinical manifestations, laboratory parameters were recorded in a standard data sheet. All the participants underwent to upper GI endoscopy and gastric biopsy were taken in all the patients. Rapid urease test and histopathology of gastric biopsy samples were done to confirm H. pylori infection. Collected data were checked manually and analyzed by SPSS version 22.0. Association of parameters with infection were done by unpaired t-test, chi-square test and fisher’s exact test. Results: Helicobacter pylori infection in children with RAP was 35.7%. Mean age of the infected children was 9.49±2.47 years with male (52%) predominance. There was significant association of infection with lower socioeconomic class (p=0.003). Patients with RAP for>6 months’ duration were significantly associated with infection (p=0.003). Family size and source of drinking water had no effect on results. Most of the RAP patients with positive infection had poor growth (p=0.003). Pallor, abdominal tenderness or vomiting were not significantly associated clinical manifestations of H. pylori infection. Conclusions: Helicobacter pylori infection is ....
Readiness for Education 4.0: Pandemic as the Wakeup Call for Teacher Education Institutions
Authors: Kumar Sachin , Kaur Manjinder
Published: January 2023

Change has been the unwritten yet self-evident law of nature and society. However, in recent times the pace, magnitude, complexities and dimensions of these changes got accelerated and intensified. The changes can be discerned in each sphere of our lives including the domain of learning and education sector. Scholars have identified four stages of Education from 1.0 to 4.0. In each of these four phases, all the characteristics change including institutional arrangement, content organisation, learning orientation, technology, teaching-learning methods, and role of students and teachers. Transition in to Education 4.0 necessitates a transformation in teacher education institutions (TEIs) because in these institutions teachers and educational administrators of future are being prepared. This paper looks at the 2 year B. Ed. curriculum prescribed by Himachal Pradesh University in 2015 and assesses the extent to which this curriculum can prepare graduates for future. The paper observes that teachers being prepared currently are not ready for roles and responsibilities they are expected to shoulder in the changed and changing scenario. It further observes that many aspects of current system of teacher education actually stand at Education 1.0 and as such requires responsive curriculum, unflinching commitment and unprecedented mobilization of resources in order to cover the long path in order to transition into 4.0 successfully. The current pandemic has potential to become a pretext for taking steps in desired direction.
Determinants of Repurchase Intention: A Study on Ease of Use, Trust and E-Satisfaction Construct in Shopee Marketplace
Authors: Nabila Eka Yoan , Listiana Erna , Purmono Bintoro Bagus , Fahruna Yulyanti , Rosnani Titik
Published: January 2023

E-commerce transforms market mechanisms in the process of interaction in buying and selling transactions. The increasing interest of consumers to carry out online purchasing activities has made companies and sellers’ market their products massively through the Internet. Through the convenience offered by the e-commerce system, people only need to visit shopping sites and order goods or services through electronic devices such as mobile phones or computers. This study aimed to examine the effect of ease of use and trust on repurchase intention mediated by e-satisfaction on Shopee online platform users. The hypothesis built in this study would be tested with a causal research design. Structural Equation Modeling (SEM) utilizing the AMOS 24 software was the statistical tool to investigate the relationship between the independent and dependent variables. The data collection method used a questionnaire with 288 respondents.
Peran Fungsi Eksekutif Otak pada Perkembangan Anak
Authors: Susanti Debie , Hasmira Hasmira , Sukarnih Putri Mulyana
Published: January 2023

Seiring dengan usia yang bertambah, anak-anak dan remaja memperlihatkan kemampuan yang lebih baik ketika mengerjakan berbagai tugas dari setiap komponen fungsi eksekutif dan pada tugas yang memerlukan koordinasi beberapa komponen fungsi eksekutif. Tujuan penelitian ini untuk mengetahui peran fungsi otak terhadap perkembangan anak. Jenis penelitian ini yakni kualitatif dengan analisis deskriptif dengan pengumpulan datanya berupa studi literatur, sehingga didapatkan dari berbagai sumber seperti artikel, buku, ataupun karya ilmiah lainnya yang berkaitan dengan topik pembahasan. Berdasarkan hasil penelitian menunjukkan bahwa kemampuan pada komponen fungsi eksekutif (inhibition, working memory dan cognitive flexibility) berkembang sesuai dengan usia perkembangan anak. Di usia 4-6 tahun kecakapan inhibition dan working memory telah timbul dan berkembang dengan baik, sementara cognitive flexibility mulai timbul sesudah usia 4 tahun, yakni usai kedua komponen fungsi eksekutif yang lainnya berkembang. Hal yang bisa berpengaruh pada perkembangan FE pada anak yaitu faktor internal (faktor keturunan dan kesehatan anak) dan juga faktor lingkungan (status sosial ekonomi, peran keluarga, dan pendidikan orangtua). Peran keluarga ini dapat berupa pengasuhan, dan kesehatan mental ibu, serta beberapa kegiatan di sekolah.
IMPROVEMENT OF THE MANAGEMENT INNOVATION SYSTEM IN THE COMPANY
Authors:   Russian University of Economics named after G. V. Plekhanov, Moscow, Russia, Velikorossov Vladimir. V. , Resin Vladimir I. ,   Russian University of Economics named after G. V. Plekhanov, Moscow, Russia, Genkin Evgeniy V. ,   Russian University of Economics named after G. V. Plekhanov, Moscow, Russia, Zakharov Aleksandr K. ,   Russian University of Economics named after G. V. Plekhanov, Moscow, Russia, Zhang Han ,   Institute of Standardization and Quality, Qingdao University, China
Published: January 2023

The purpose of the article is to develop and propose recommendations for improving the management innovation system in companies. The following methods were used: general scientific dialectical and formal-logical, historical, comparative and system analysis and generalization. The concepts and essence, functions and significance of managerial innovations, their classification and the need to improve the efficiency of the company are analyzed. The world experience of forming a system by management innovations is analyzed, their advantages and disadvantages are discussed; methodological approaches to the formation of such a system in the company are discussed. The conclusion is made: managerial innovations are the most important aspect of the company’s development in order to effectively adapt to new conditions.
Drug/Natural Products-Related problems in Elderly
Authors: Zailani Izni Syahirah , Moshawih Said , Kifli Nurolaini , Abd Wahab Mohd Shahezwan , Lee Kah Seng , Ming Long Chiau
Published: January 2023

Herbal remedies have risen for decades in developed and developing countries. In this systematic review, the herbs such as cannabis, St. John's wort, kava, turmeric, grapefruit, bitter orange, ginger, garlic, and Chinese Herbal tea are discussed to interact with medicines and potentially cause adverse reactions. This study aimed to investigate the occurrence and prevalence of drug/NP interactions in healthy volunteers or patients with comorbidities in elderly populations above 65. A systematic literature review was conducted using PubMed, Google Scholar, Scopus, Cochrane, and MedRxiv databases, from May 2022 until July 2022. Studies investigating drug/NP-related problems (DNRP) in healthy patients or patients with comorbidities were included. The data obtained was then commenced with the quality assessment by the Joanna Briggs Institute (JBI) tool. The inclusion criteria comprised six studies demonstrating that most drug classes associated with DNRP were represented by Selective Serotonin reuptake inhibitors (SSRIs), kinase inhibitors, and anti-neoplastic agents. Factors linked to DNRP are age, the number of medications, gender, five or more prescribed drug, presence of comorbidity, underestimation of potential adverse events, and length of hospitalization. This systematic review has proven that DNRPs may occur due to herb-drug interaction or multi-medication consumption. Limitations such as patients not disclosing their DNRPs to pharmacists may affect the investigation. At the same time, larger sample sizes are required to unfold the real problem in future studies.
Streptomyces griseiviridis sp. nov., A Novel “Modern Actinobacteria” isolated from Malaysia Mangrove Soil
Authors: Law Jodi Woan Fei , Tan Loh Teng-Hern , Letchumanan Vengadesh , Hong Kar-Wai , Ser Hooi-Leng , Goh Bey-Hing , Ab Mutalib Nurul Syakima , Chan Kok-Gan , Lee Learn-Han
Published: January 2023

A novel strain, Streptomyces griseiviridis MUM 136JT was recovered from a mangrove forest soil in Malaysia. The Gram-positive bacterium forms strong yellow aerial mycelium and moderate yellow substrate mycelium on ISP 2 agar. A polyphasic approachwas used to determine the taxonomy status of strain MUM 136JT. The strain showed a spectrum of phylogenetic and chemotaxonomic properties consistent with those of the members of the genus Streptomyces. The cell wall peptidoglycan was determined to contain LL-diaminopimelic acid. The predominant menaquinones were identified as MK-9(H8) and MK-9(H6), while the identified polar lipids consisted of lipid, aminolipid, phospholipid, phosphatidylglycerol, phosphatidylinositol, phosphatidylethanolamine, diphosphatidylglycerol, and phosphatidylinositolmannoside. The cell wall sugars consist of ribose, mannose, and galactose. The predominant cellular fatty acids (>10.0 %) were identified as iso-C16:0 (31.6 %), anteiso-C15:0 (14.8 %), iso-C15:0 (12.0 %), and anteiso-C17:0 (11.1 %). Phylogenetic analysis identified that closely related strains for MUM 136JT are Streptomyces leeuwenhoekii DSM 42122T (98.9 %), Streptomyces erythrogriseus JCM 9650T (98.4 %), Streptomyces griseoincarnatus JCM 4381T (98.5 %). The DNA-DNA relatedness values between MUM 136 JT and closely related type strains ranged from 13.3 ± 1.5 % to 17.4 ± 2.0 %. The name Streptomyces griseiviridis sp. nov. is proposed, and the type strain is MUM 136JT (= NBRC 114249T = MCCC 1K04199T).
Autoimmune thyroid disease in narcolepsy: A case report
Authors: Geng Chaofan , Yang Zhenzhen , Zhang Hongju
Published: January 2023

While the previous studies have discussed the association of narcolepsy with autoimmune diseases, autoimmune thyroid disease (IATD) has rarely been described in patients with narcolepsy. The association of narcolepsy with thyroid disease is intriguing for speculating the causal or coexisting autoimmune disorder. We report a case of narcolepsy Type 1 with IATD, presenting with excessive daytime sleepiness (EDS), cataplexy attacks, and unexplainable weight gain. Oral modafinil and sodium oxybate were used for treatment and prevention. During the 1-year follow-up, the patient’s EDS and cataplexy attacks improved. However, the patient developed hypothyroidism and was subsequently prescribed with thyroid replacement therapy.
CAR-T cells : what intensivists need to know
Authors: Valade Sandrine , Zafrani Lara
Published: January 2023

Treatment with CAR-T cells represents an innovative therapeutic advance in patients with refractory hematological malignancies. Infectious complications must always be considered and empirically treated. Specific complications such as cytokine release syndrome (CRS) and neurotoxicity can be severe and patients often require intensive care unit admission. A close monitoring is necessary in these patients. While CRS treatment is based on the administration of anti-IL-6 receptor (tocilizumab) in mild forms, corticosteroids are recommended in severe CRS and/or neurotoxicity
Decompressive craniectomy as a rescue treatment in Herpes simplex encephalitis-related cerebral edema: a case report and literature review
Authors: Malhomme Rémi , Pommier Jean-David , Flurin Laure , Carles Michel , Do Laurent
Published: January 2023

We present a case of herpes simplex encephalitis requiring decompressive craniectomy for high intracranial pressure, and a review of decompressive craniectomy in herpes simplex encephalitis. 
Case description and review: a 32-year-old man was brought to emergency department for headache and fever. The cerebral spinal fluid examination found lymphocytic meningitis; treatment by acyclovir was initiated 4 days after admission. At day 5, patient developed clinical signs of high intracranial pressure and CT-scan showed cerebral herniation. After medical management fail, a decompressive craniectomy was performed on the same day. The procedure resulted in a good clinical recovery with minor neurological sequelae. A literature review, presented here, found few cases of decompressive craniectomy in herpes simplex encephalitis. Due to a lack of robust clinical data, no guideline are yet available.
In summary, a surgical approach, such as a decompressive craniectomy, in herpes simplex encephalitis with high intracranial pressure should be discussed early, in association with the medical treatment. Prospective data are needed to better define timing of surgery and decision-making criteria.
Insuffisance rénale aiguë chez les patients COVID-19 en soins intensifs
Authors: Gabarre Paul , Dumas Guillaume , Zafrani Lara
Published: January 2023

L’insuffisance rénale aigue au cours de l’infection sévère par le SARS-CoV2 est fréquente, et est associée à une surmortalité. Elle est multifactorielle, associant des mécanismes non spécifiques (défaillance hémodynamique, PEP, iatrogénie) et des mécanismes plus spécifiques au COVID-19 (invasion virale, endothélite et thrombose, activation du système rénine angiotensine aldostérone, et élévation de cytokines pro-inflammatoires). Les troubles ioniques observés au cours de l’infection par la COVID-19 sont des marqueurs de gravité. La lésion histologique la plus fréquemment rencontrée est la nécrose tubulaire aiguë mais elle peut révéler des glomérulopathies. Il n’existe à ce jour aucun traitement spécifique de l’atteinte rénale du COVID-19.
Mise au point sur les intoxications au baclofène et son syndrome de sevrage
Authors: Léger Maxime , Lerolle Nicolas , Descatha Alexis , Legeay Marion
Published: January 2023

Le baclofène, initialement utilisé comme traitement antispastique, est depuis plusieurs années prescrit chez les patients alcoolodépendants pour favoriser le sevrage alcoolique. La France présente la spécificité d’avoir autorisé la mise sur le marché du baclofène dans cette indication depuis 2018. Les patients alcoolodépendants présentent un risque accru de tentative de suicide, notamment par intoxication volontaire.  L’incidence des intoxications volontaires au baclofène s’est majoré sur la dernière décennie. Comparativement aux autres intoxications, celle-ci présente un recours fréquent à la ventilation mécanique (50% des cas) et une léthalité significative (plus de 2% des cas). Le toxidrome de l’intoxication aiguë au baclofène se résume principalement à une dépression du système nerveux central, pouvant aller de la sédation jusqu’au coma, et nécessitant une surveillance continue pour des doses suspectées ingérées supérieures à 200 mg. Le dosage plasmatique du baclofène permet de confirmer le diagnostic et de suivre l’évolution de l’élimination de la molécule. La principale voie d’élimination est rénale, motivant une surveillance accrue de la fonction rénale dans ce contexte. L’épuration extrarénale pourra se discuter dans les intoxications les plus sévères associées à une insuffisance rénale aiguë. Le reste de la prise en charge reste symptomatique, sans antidote existant. Le syndrome de sevrage au baclofène se rencontre lors d’un arrêt brutal du traitement, et peut être composé des symptômes suivants : spasticité, hyperthermie, agitation, rhabdomyolyse. Il peut compliquer l’hospitalisation de patients traités au long cours admis pour une intoxication aiguë. Son traitement nécessite une réintroduction précautionneuse du baclofène.
COVID-19 : les leçons de la pandémie
Authors: Timsit Jean-François
Published: January 2023

Les réanimateurs francais ont été confrontés à la première pandémie depuis plus d'un siècle. Cette éditorial fait le point sur ce que nous avons appris et sur les potentielles faiblesses des soins et de la recherche dans des conditions si dramatiques.
Diagnostic d’infection par le SARS-CoV-2 : tests disponibles et stratégie en réanimation
Authors: Mahieu Rafael , Dubée Vincent
Published: January 2023

Depuis le début de l’épidémie de COVID-19 l’interprétation des tests diagnostiques a évolué à la faveur d’une meilleure compréhension de leurs performances malgré l’absence de gold standard solide. Si la RT-PCR SARS-CoV-2 reste au centre de la démarche diagnostique, son manque de sensibilité peut nécessiter d’utiliser des approches combinées intégrant le scanner thoracique et la répétition de tests virologiques. L’analyse des résultats de ces examens doit impérativement prendre en compte la probabilité pré-test qui dépend de la situation épidémiologique et de la présentation clinique du patient. De nouvelles techniques de biologie moléculaire parfois au sein de PCR multiplex, des tests rapides de détection d'antigènes et la sérologie viennent compléter l’arsenal des outils disponibles.
Etat des lieux de l’envenimation par morsure de serpent en 2019 au CHU Gabriel Touré de Bamako : Particularités cliniques, pronostiques et évaluation de la disponibilité des SAV
Authors: Mahamadoun COULIBALY , MANGANE Moustapha I , OUEDRAGO Youssouf , KOITA Siriman A , DIOP Madane T , MAIGA Hamidou A , NIENTAO Ousmane , BAGAYOGO Drissa K , DEMBELE Aladji S , DJIBO Diango M , COULIBALY Youssouf
Published: January 2023

Objectif : L’objectif était d’apporter une mise à jour des données épidémiologiques, évaluer la prise en charge de ces envenimations et faire ressortir les facteurs pronostiques de ces affections dans notre contexte.

Patients et Méthodes : Il s’agissait d’une étude prospective transversale allant du 01 Février 2019 au 31 Janvier 2020, ont été inclus à l’étude tous patients admis au service d’accueil des urgences du CHU Gabriel TOURE de Bamako pour envenimation par morsure de serpent. Les caractéristiques démographiques, cliniques, paracliniques, thérapeutiques ont été relevées sur une fiche d’exploitation préalablement établie. Les données ont été saisies sur WORD 2013 et analysées sur SPSS 21.

Résultats : 126 cas d’envenimations ont été inclus à l’étude. L’âge moyen des patients était de 25 ans ; le sexe masculin représentait 63,5% des cas. La période hivernale était la période de prédilection des morsures. Le délai de consultation était > 72H dans 40,5%. Un syndrome hémorragique était présent dans 77% des cas. L’hémopéritoine de grande abondance, l’hémorragie intracrânienne, les fausses couches et l’insuffisance rénale étaient les principales complications rencontrées. Nous avons enregistré une mortalité de 10%.

Conclusion : Des progrès ont été observés quant à l’approvisionnement en SAV au Mali depuis 2016. Au Mali, l’incidence et la gravité de cette pathologie restent encore mal connues. Les études réalisées sur ce sujet sont rares et se limitent à quelques centres hospitaliers. Une meilleure évaluation de l’incidence et de la morbidité est pourtant indispensable pour améliorer la prise en charge.
L’épreuve de ventilation spontanée
Authors: Courtais Antonin , Richard Jean-Christophe , Mercat Alain , Beloncle François
Published: January 2023

L’épreuve de ventilation spontanée (EVS) est un élément clé de la phase de sevrage de la ventilation mécanique. L’objectif d’une EVS est de mimer les conditions de ventilation après l’extubation et donc d’aider le clinicien à prédire le résultat d’une décision d’extubation.  La réalisation systématique d’une EVS quotidiennement, lorsque des critères prédéfinis sont réunis, permet de diminuer la durée de ventilation mécanique. Différentes méthodes et durées d’EVS ont été étudiées. Le travail respiratoire est plus important lors d’une EVS sur pièce en T que lors d’une EVS en aide inspiratoire.  La réalisation de l’EVS en aide inspiratoire permet un taux de réussite de l’EVS supérieur à celui observé avec une pièce en T sans majoration du risque de réintubation. Une durée de 30 minutes pourrait être suffisante chez certains patients. Cependant, le choix du type et de la durée de l’EVS doit s’inscrire dans le cadre d’une stratégie de service, tenant compte des caractéristiques des patients concernés et le moment de la réalisation de l’EVS dans le processus de sevrage.
Les spécificités de l'arrêt cardiaque intra-hospitalier et sa prise en charge.
Authors: Lascarrou Jean Baptiste , Bougouin Wulfran , Dumas Florence , Canet Emmanuel , Legriel Stéphane , Javaudin François , Cariou Alain
Published: January 2023

L’arrêt cardiaque intra hospitalier (ACIH) est un évènement rare (1 cas pour 1000 admissions hospitalières approximativement) mais associé à une mortalité et une morbidité importante. Beaucoup d’éléments de la prise en charge sont calqués sur l’arrêt cardiaque extrahospitalier (ACEH) et/ou la disponibilité immédiate d’un plateau technique hospitalier complet.

La prévention incluant l’amélioration de la détection des ACIH, mais aussi la prédiction de leur survenue nécessite la mise en place de registre exhaustif tels qu’ils existent déjà dans des pays notamment scandinaves mais font défaut en 2021 en France.

Les causes de l’ACIH sont équilibrées entre causes cardiaques similaires aux ACEH et causes extracardiaques avec en premier lieu l’asphyxie. Cette épidémiologie conduit à une prise en charge spécifique de manière plus fréquente que dans le cadre de l’ACEH. La prise en charge non spécialisée repose sur les compressions thoraciques, l’oxygénation avec ou sans intubation trachéale et l’administration d’Adrénaline.

La prise en charge après récupération d’une activité cardiaque spontanée est guidée par l’étiologie et les mesures neuroprotectrices pouvant être proposées. L’évaluation du pronostic étant cruciale comme dans le cadre de l’ACEH avec néanmoins une place particulière pour les comorbidités, la fragilité et la pathologie responsable du séjour hospitalier.