bluuebunny/crossref_metadata_2025 huggingface dataset:
Triad of cluster-like headaches, hypertension and hypercoagulability a pointer to pheochromocytoma
Authors: Rampuria Archana , Mathew Thomas , Honnali Ravindranath Aditya
Published: February 2024

We report the case of a middle-aged hypertensive woman presenting to the neurology department with short-lasting episodic headaches for 4 years. She was initially diagnosed and treated with cluster headaches for one year. Following this, she presented with right lower limb arterial claudication. Arterial Doppler of lower limbs showed thrombosis of the bilateral common femoral arteries. Further computed tomography (CT) angiogram of the lower limbs confirmed extensive arterial thrombosis in bilateral lower limbs. The CT angiogram incidentally detected a left adrenal lesion. She had elevated urinary vanillylmandelic Acid and 24-hour metanephrines suggesting the presence of a pheochromocytoma. She was initially medically managed and later underwent left open adrenalectomy. Histopathology examination of the sections proved pheochromocytoma. Postsurgery, the patient’s symptoms improved remarkably. This case highlights the importance of diagnosing pheochromocytoma when you encounter a patient with refractory short-lasting headaches, hypertension and hypercoagulability.
Concurrent replacement of four major joints in a woman with advanced rheumatoid arthritis
Authors: Tripathy Sujit K , Jain Mantu , Varghese Paulson , Jena Sritam
Published: February 2024

We report a case of a woman in her mid-40s with advanced rheumatoid arthritis (RA), with bilateral hip and knee joint involvement, who underwent a one-stage quadruple joint arthroplasty during a single session of anaesthesia. Chronic RA had severely incapacitated her, necessitating this uncommon surgical intervention. The surgical approach involved sequential bilateral total hip and knee replacements, which were completed within 180 min with a cumulative blood loss of 950 mL. The patient showed significant improvement with rapid mobilisation and regained joint function postoperatively. At 8 months post-surgery, the patient resumed her daily activities, showcasing the potential benefits and positive outcomes of quadruple joint arthroplasty in selected RA patients. This case, only the second documented globally, highlights the complexities and possibilities surrounding a single-stage quadruple joint arthroplasty in advanced RA.
Ethical preparedness in genomic medicine: how NHS clinical scientists navigate ethical issues
Authors: Sahan Kate , Lyle Kate , Carley Helena , Hallowell Nina , Parker Michael J , Lucassen Anneke M
Published: February 2024

Much has been published about the ethical issues encountered by clinicians in genetics/genomics, but those experienced by clinical laboratory scientists are less well described. Clinical laboratory scientists now frequently face navigating ethical problems in their work, but how they should be best supported to do this is underexplored. This lack of attention is also reflected in the ethics tools available to clinical laboratory scientists such as guidance and deliberative ethics forums, developed primarily to manage issues arising within the clinic.

We explore what ethical issues are being experienced by clinical scientists, how they think such issues could be best analysed and managed, and whether their practice might be enhanced by more situated approaches to ethics deliberation and practice such as ethical preparedness. From thematic analysis of cases presented by clinical scientists at a specially convened meeting of the UK Genethics Forum, we derived three main ethical themes: (1) the redistribution of labour and responsibilities resulting from the practice of genomic medicine; (2) the interpretation and certainty of results and (3) the proposal that better standardisation and consistency of ethical approaches (for example, more guidelines and policy) could resolve some of the challenges arising.

We argue that although standardisation is important for promoting shared understandings of good (including ethical) practice, supplementary approaches to enhance and sustain ethical preparedness will be important to help clinical scientists and others in the recently expanded genetic/genomic medicine environment foster quality ethical thinking.
Development of the Pediatric Integrated Nutrition Pathway for Acute Care (P-INPAC) using a modified Delphi technique
Authors: Brunet-Wood Kim , Tul-Noor Zujaja , Bandsma Robert H.J. , Carter Laura , Fleming-Carroll Bonnie , Gramlich Leah , Hutchison Kim , Huysentruyt Koen , Kalnins Daina , Marchand Valerie , Martinez Andrea , Pai Nikhil , Vachon Mélanie , Hulst Jessie M.
Published: February 2024

One in three hospitalized children have disease-related malnutrition (DRM) upon admission to hospital, and all children are at risk for further nutritional deterioration during hospital stay; however, systematic approaches to detect DRM in Canada are lacking. To standardise and improve hospital care, the multidisciplinary pediatric working group of the Canadian Malnutrition Taskforce aimed to develop a pediatric, inpatient nutritional care pathway based on available evidence, feasibility of resources, and expert consensus. The working group ( n = 13) undertook a total of four meetings: an in-person meeting to draft the pathway based on existing literature and modelled after the Integrated Nutrition Pathway for Acute Care (INPAC) in adults, followed by three online surveys and three rounds of online Delphi consensus meetings to achieve agreement on the draft pathway. In the first Delphi survey, 32 questions were asked, whereas in the second and third rounds 27 and 8 questions were asked, respectively. Consensus was defined as any question/issue in which at least 80% agreed. The modified Delphi process allowed the development of an evidence-informed, consensus-based pathway for inpatients, the Pediatric Integrated Nutrition Pathway for Acute Care (P-INPAC). It includes screening <24 h of admission, assessment with use of Subjective Global Nutritional Assessment (SGNA) <48 h of admission, as well as prevention, and treatment of DRM divided into standard, advanced, and specialized nutrition care plans. Research is necessary to explore feasibility of implementation and evaluate the effectiveness by integrating P-INPAC into clinical practice.
Women in Canada are consuming above the upper intake level of folic acid but few are meeting dietary choline recommendations in the second trimester of pregnancy: data from the CHILD cohort study
Authors: Wiedeman Alejandra M. , Miliku Kozeta , Moraes Theo J. , Mandhane Piushkumar J. , Simons Elinor , Subbarao Padmaja , Turvey Stuart E. , Zwicker Jill G. , Devlin Angela M.
Published: February 2024

There is concern that during a low-risk pregnancy, women are consuming more than recommended (400 µg/day) supplemental folic acid and may not meet recommendations for other nutrients. The objective of this study was to determine folic acid supplement use and dietary folate intakes in the second trimester (week 18) of pregnancy in women ( n = 2996) in the Canadian CHILD cohort study. Vitamin B12 and choline intakes were also assessed because they are metabolically related to folate. The majority of participants (71.6%) were consuming a daily prenatal supplement. Twenty-eight percent of women ( n = 847) reported consuming a folic acid supplement and of these women, 45.3% had daily supplemental folic acid intakes above the upper intake level (UL; 1000 µg/day). Daily dietary folate intakes were (mean (SD)) 575 (235) DFE µg/day. In contrast, only 24.8% of women met the dietary choline adequate intake (AI) recommendation (AI ≥ 450 mg/day) with a mean (SD) intake of 375 (151) mg/day. Further understanding of the impact of supplemental folic acid intake above the UL and low choline intake during pregnancy requires further investigation.
Targeting antibiotic pollution: an investigation of azithromycin in wastewater by electrochemical surface-enhanced Raman spectroscopy
Authors: Ball Rachael B.E. , Brosseau Christa L.
Published: February 2024

Azithromycin is a macrolide antibiotic that is commonly prescribed to treat infections of the skin, soft tissues, and the upper and lower respiratory tracts. Many antibiotics, including azithromycin, are overprescribed, leading to elevated concentrations of these drugs in bodies of water; this phenomenon is referred to as antibiotic pollution. Antibiotic pollution is increasingly concerning, due to its implications for the development of antibiotic resistance and its potential ecotoxicity. Rapid detection of azithromycin in wastewater could be important for addressing antibiotic pollution. This research highlights the development of a direct electrochemical surface-enhanced Raman spectroscopy method for the detection of azithromycin in synthetic wastewater. The coupling of electrochemistry and surface-enhanced Raman spectroscopy allowed enhanced detection of azithromycin and its derivatives in wastewater. To the best of our knowledge, this is the first report of direct detection of azithromycin using electrochemical surface-enhanced Raman spectroscopy. This novel detection method has promising application in future research concerning antibiotic pollution.
Determination of the effectiveness of porcelain fine waste to enhance the performance of geopolymer concrete with recycled waste using central composite design and Taguchi method
Authors: Gour Chandra Prakash , Dhurvey Priyanka
Published: February 2024

This study aims to evaluate the effectiveness of incorporating bone china fine aggregate (BCA) in geopolymer concrete (GPC) with recycled coarse aggregate (RCA). A total of 25 experiments were conducted to optimize the mix design of GPC with coarse RCA and fine BCA. The suitability of a response surface model using the central composite design approach and the Taguchi method with an L25 orthogonal array was assessed. Both methods provide valuable insights and recommendations for achieving ideal mix proportions to enhance strength. The resulting model, with a higher coefficient of determination, successfully predicted the mechanical properties of GPC in fresh and hardened states. The findings suggest that GPC with up to 50% RCA and up to 100% BCA demonstrates optimal performance in terms of hardened mechanical properties. Furthermore, a strong correlation was observed between the predicted and actual values, indicating the reliability of the model.
Soil responses to inclusion of corn, soybean, and cover crops under rainfed conditions in the northern Great Plains
Authors: Liebig Mark A. , Archer David W. , Halvorson Jonathan J. , Clemensen Andrea K. , Hendrickson John R. , Tanaka Donald L.
Published: February 2024

Crop rotations in the northern Great Plains of North America increasingly include corn ( Zea mays L.) and soybean ( Glycine max (L.) Merr.). Use of cover crops, while less extensive, is also increasing given their purported agronomic and environmental benefits. To date, soil responses to the inclusion of corn, soybean, and cover crops in rainfed cropping systems have not been well documented in the region. Therefore, soil properties were evaluated 6 years after establishment of three crop rotations (spring wheat ( Triticum aestivum L.)–soybean (SW–S), spring wheat–corn–soybean (SW–C–S), and spring wheat–corn–cover crop (SW–C–cc)) each split by no and minimum tillage on a Dark Brown Chernozem near Mandan, ND, USA. Soil responses to treatments were subtle and exclusive to the 0–7.6 cm depth. Soil pH was lower in SW–S than SW–C–cc (5.28 vs. 5.48; P = 0.05), SO4-S was greater under SW–C–cc than SW–C–S (13.4 vs. 11.6 g S kg−1; P = 0.03), exchangeable K was greater under SW–C–S and SW–C–cc than SW–S (0.83 cmol kg−1 vs. 0.52 cmol kg−1; P = 0.05), and water-stable aggregates were greater in SW–S than SW–C–S (26% vs. 19%; P = 0.08). Soil organic carbon (SOC) and total N did not differ among crop rotations or between tillage treatments, while particulate organic matter N was greater under no tillage compared to minimum tillage ( P = 0.08). Between 2012 and 2018, soil pH decreased and SOC increased under SW–C–S. Frequent monitoring of near-surface soil conditions in rotations with soybean every other year is recommended. Furthermore, innovative management practices are needed to enhance soil C and N fractions in rotations with full-season cover crops.
Integrating Network Information Into Credit Classification Models
Authors: An Le T. T. , Anh Hoang T. K. , Anh Luu M. , Mien Mai T. , Oanh Phan T. K.
Published: February 2024

Some qualitative studies have mentioned the impact of trading networks on the credit levels of countries or businesses. However, only a few studies quantified network information on simulated or actual data. This research studied the relationship between network characteristics and sovereign credit levels. Using a data set for 114 countries, we developed and compared the performance of five credit classification models with and without integrating network information.

We used several measures to quantify the trading network information, such as Trading Weight, Closeness, Betweenness, PageRank, and Modularity. The analysis showed that they were closely related to credit levels. In particular, the Trading Weight usually belonged to the top five critical features for almost all classifiers. Overall, we saw that the correct prediction of the network models was consistently higher than those without a network. It meant we could improve the sovereign credit classifications with available trading network information.
Structure of the Plio-Quaternary coastal aquifer (Mediterranean Basin, Tunisia): insights from gravity and seismic analysis
Authors: Ayari Sana , Ghouili Nesrine , Gabtni Hakim , Zouhri Lahcen
Published: February 2024

This research paper presents an investigation of an aquifer structure using a combination of gravity and seismic analyses, calibrated by hydrogeological data. This work illustrates how crucial it is to study geological structures and fault networks as preliminary work to understand water- and pollutant-flow systems and aquifer vulnerability, especially with the increased frequency of drought events and climate change pressures. A Plio-Quaternary coastal northeastern aquifer in Tunisia was chosen as the study case.

First, a hydrogeological approach was performed using water wells, and piezometer data showed an important fluctuation in the piezometric level and a notable depression in the piezometric surface observed in the southern part of the study area.

Secondly, gravity data were analysed and calibrated using a seismic profile. The results demonstrated the presence of shallow NE–SW faults less than 300 m below the region's principal wadis, as well as deeper faults of varying depths (from 400 to 2600 m) that influence the basin structure, aquifer geometry and resulting water flow.

The combination of these approaches revealed that the variations in the aquifer thickness, piezometric surface depression zones and groundwater flow are mainly controlled by shallow and deep geological structures and their tectonic reactivation.
The John Mitchell Lecture 2023: road asset, socio-economic and fatality risk from debris flow
Authors: Winter M. G.
Published: February 2024

Fast-moving, rainfall-induced debris-flow events are relatively common in the mountainous areas of the UK. The mechanisms of such debris flows are considered as they bridge between slow mass movements and flood phenomena. A series of case studies of debris-flow impacts from Scotland and overseas is described. The assessment of landslide hazards and risks are essential precursors to landslide risk reduction. This is particularly the case when an authority is responsible for an infrastructure or building portfolio that may be affected by multiple hazards. A framework for risk acceptance is used to set the context, and the use of a semi-quantitative assessment to determine the sites of highest risk is described. These highest risk sites are subject to quantitative risk assessments for road-user fatalities as a result of debris flows. A novel approach is taken to assess the socio-economic risks and the use of fragility curves to articulate the vulnerability of road infrastructure, including the newly developed approach involving systems of assets, is also described. The effects of climate change are considered alongside likely social and/or demographic change. A strategic approach to landslide risk reduction is used to illustrate how a clear focus on the overall goal of risk reduction can be beneficial in developing an effective strategy before homing in on the desired outcomes and the generic approach to achieving those outcomes.
Future Business Workforce: Crafting a Generative AI-Centric Curriculum Today for Tomorrow's Business Education
Authors: Nithithanatchinnapat Benyawarath , Maurer Joshua , Deng Xuefei (Nancy) , Joshi K. D.
Published: February 2024

In an era where generative AI is reshaping the landscape of business and technology, this editorial addresses the critical imperative for transformative reform in business education. It emphasizes the dual nature of generative AI as both a formidable disruptor and a catalyst for innovation, necessitating a shift in how we educate the future workforce. The editorial calls for a proactive and comprehensive reevaluation of current educational models, advocating for an integration of AI literacy and ethical considerations into the core of business curricula. We aim to galvanize academia into action, advocating for an educational evolution that not only acknowledges the challenges posed by AI but also harnesses its potential to enrich and advance business education in preparing students for an AI-driven future.
PIK3CA-Related Disorders: From Disease Mechanism to Evidence-Based Treatments
Authors: Morin Gabriel M. , Zerbib Lola , Kaltenbach Sophie , Fraissenon Antoine , Balducci Estelle , Asnafi Vahid , Canaud Guillaume
Published: February 2024

Recent advances in genetic sequencing are transforming our approach to rare-disease care. Initially identified in cancer, gain-of-function mutations of the PIK3CA gene are also detected in malformation mosaic diseases categorized as PIK3CA-related disorders (PRDs). Over the past decade, new approaches have enabled researchers to elucidate the pathophysiology of PRDs and uncover novel therapeutic options. In just a few years, owing to vigorous global research efforts, PRDs have been transformed from incurable diseases to chronic disorders accessible to targeted therapy. However, new challenges for both medical practitioners and researchers have emerged. Areas of uncertainty remain in our comprehension of PRDs, especially regarding the relationship between genotype and phenotype, the mechanisms underlying mosaicism, and the processes involved in intercellular communication. As the clinical and biological landscape of PRDs is constantly evolving, this review aims to summarize current knowledge regarding PIK3CA and its role in nonmalignant human disease, from molecular mechanisms to evidence-based treatments.
The Plot Thickens: A Sociology of Conspiracy Theories
Authors: Rao Hayagreeva , Greve Henrich R.
Published: February 2024

Conspiracy theories are a constant feature of human society but have recently risen in prominence with the flurry of COVID-19 conspiracy theories and their public display in social media. Conspiracy theories should be studied not only because of their potential harm but also because they are related to other sources of misinformation such as folk theories, rumors, and fake news. Recent understanding of their spread has shifted the focus from investigating the believers to characteristics of the social processes that motivate and persuade, with a new view of the conspiracy theorist as a bricoleur dealing with threats through social (re)construction of reality. These tendencies are strengthened by the markets for attention and approval constructed by social media platforms, and bots also amplify them. We identify an agenda of multiple important and urgent paths for future research that will help understanding of conspiracy theories in society.
Presumed Competent: The Strategic Adaptation of Asian Americans in Education and the Labor Market
Authors: Lee Jennifer , Goyette Kimberly , Song Xi , Xie Yu
Published: February 2024

Presumed competent, Asian Americans exhibit the highest level of education and median household income of all major US ethnoracial groups. On average, they outpace all groups in the domain of education, yet they do not maintain their advantage in the labor market. The question of bias against Asian Americans has taken center stage in the most recent US Supreme Court ruling on affirmative action, but the attention has been on university admissions. We broaden the focus and rewrite the question to consider how Asian Americans seek to preempt bias in the labor market by strategically adapting to mitigate it. Strategic adaptation begins with precollege education, continues with college choice and major, and entails acquiring elite credentials that signal hard skills and merit. The strategy falls short of obviating bias altogether, however. We show how Asian Americans’ labor market earnings and mobility vary by gender, nativity, national origin, place of education, and field of study.
Recapitulation of human pathophysiology and identification of forensic biomarkers in a translational model of chlorine inhalation injury
Authors: Achanta Satyanarayana , Gentile Michael A. , Albert Carolyn J. , Schulte Kevin A. , Pantazides Brooke G. , Crow Brian S. , Quiñones-González Jennifer , Perez Jonas W. , Ford David A. , Patel Rakesh P. , Blake Thomas A. , Gunn Michael D. , Jordt Sven E.
Published: February 2024

We established a swine model of chlorine gas-induced acute lung injury that exhibits several features of human acute lung injury and is suitable for screening potential medical countermeasures. We validated chlorinated fatty acids and protein adducts in plasma and lung samples as forensic biomarkers of chlorine inhalation.
Antigen stasis and airway nitrosative stress in human primary ciliary dyskinesia
Authors: Gaston Benjamin , Smith Laura A. , Davis Michael D. , Saunders Jessica , Daniels Ivana , Horani Amjad , Brody Steven L. , Giddings Olivia , Zhao Yi , Marozkina Nadzeya
Published: February 2024

The PCD airway epithelium does not optimally clear antigens, and antigen exposure can lead to NO oxidation and nitrosative stress. Oxidation caused by antigen stasis could represent a therapeutic target in PCD, and there are convenient monitoring biomarkers.
Soil Physicochemical Properties Variation under Annual Crop and Coffee Landuse in the Chentale Watershed, Upper Blue Nile Basin, Ethiopia
Authors: Tebekew Feven Azene , Tadesse Teshome Betru , Alemu Desta Adane , Ayalew Amsalu Awoke
Published: February 2024

A detrimental decline in soil fertility has been attributed to losses in arable land productivity in Ethiopia. In this line, several studies were conducted to enable informed decisions; however, monitoring soil property dynamics in different biophysical, climatic, and cropping systems is yet to be adequate to support and influence decision and policymakers. To this end, this study evaluated soil physicochemical properties on land managed for annual crops and coffee land use in the Chentale watershed, the upper Blue Nile basin, Ethiopia. About 24 soil samples were collected from the two land uses and soil depths (topsoil: 0–15 cm and subsoil: 15–30 cm) with 6 replications for soil properties analysis. The result showed that most of the soil parameters varied significantly with land uses and were higher with coffee landuse (p<0.01) than with cropland. Furthermore, a neutral pH range, clay loam texture, medium level of organic matter (3.93%) and nitrogen (0.18%), high level of available phosphorus (23.35 PPM), and high to very high level of exchangeable base were recorded from coffee landuse than from cropland. Whereas the mean values of organic matter (OM) and total nitrogen (TN) decreased significantly (p<0.05) decreased in the subsoil. However, most of the physical and chemical properties of the soil did not vary significantly with depth. Moreover, low pH, low OM content, and low TN are the main properties of soil considered constraints of soil fertility in cropland at both depths. Therefore, it is recommended to maintain agroforestry practices, reduce the intensity of tilling, and supply organic materials to sustain the productivity of cropland.
MHD Natural Convection and Sensitivity Analysis of Ethylene Glycol Cu‐Al2O3 Hybrid Nanofluids in a Chamber with Multiple Heaters: A Numerical Study of Lattice Boltzmann Method
Authors: Anee Meratun Junnut , Hasan Md Farhad , Siddiqa Sadia , Molla Md. Mamun
Published: February 2024

The present work investigates the magnetohydrodynamic (MHD) convective heat transport of hybrid nanofluids in a chamber with multiple heaters (such as hot microchips). The multiple‐relaxation‐time (MRT) lattice Boltzmann method (LBM) and graphics processing unit (GPU) computing are used here. The present study is important due to its relevance to real‐world applications, the use of advanced simulation techniques, the consideration of hybrid nanofluids, the inclusion of magnetohydrodynamics, and the identification of critical parameters influencing heat transfer. Thermally homogeneous blocks are set at the bottom of a rectangular enclosure filled with ethylene glycol Cu‐Al2O3 hybrid nanofluids with temperature‐dependent viscosity. The cold temperature of the enclosure’s left and right walls and the bottom and top surfaces is kept at adiabatic conditions. The numerical outcomes for the various parameters Rayleigh number (104 ≤ Ra ≤ 106), volume fraction (0.00 ≤ ϕ ≤ 0.04), Hartmann number (0 ≤ Ha ≤ 60), and viscosity variation parameter (0 ≤ ε∗ ≤ 5) are presented in terms of streamlines, isotherms, and the peripheral local and average Nusselt numbers for the heated chips. The results demonstrated that inside the chamber, the Rayleigh number (Ra), the Hartmann number (Ha), and the volume fraction of nanoparticles (ϕ) have the highest impact on the heat transfer rate for hybrid nanofluid. For increased Ha from 0 to 20, while ϕ = 0.0 and Ra = 106, average Nusselt number decreased with 13.65%. For the same case, if the volume fraction was increased to ϕ = 0.04, then the average Nusselt number decreased 14%. Finally, a sensitivity analysis was done to analyze the system’s correctness and effectiveness to determine the significance of the specified parameters.
Analysis of Different PWM Techniques for Enhanced Ultrahigh Gain Z-Network Topology
Authors: Jagan Vadthya , Maheshwaram Bhavadish Chary , Usirikapally Mallesh , Balachandran Praveen Kumar , Reddy B. Nagi , Mettu Sankeerthana , Dhanamjayulu C. , Arunkumar G. , Saranya K. C. , Khan Baseem
Published: February 2024

In these modern times, the Z-source inverters (ZSIs) have become a revolutionary invention ever since the year 2002. The pulse-width modulation (PWM) technique used for most of the ZSIs is simple boost control PWM (SBC-PWM), and the SBC-PWM implies for a greater voltage stress on the inverter bridge and provides less boost factor. Likewise, many topologies for the basic Z-source topologies are evolved, and different PWM techniques are applied to them such as maximum boost control (MBC), maximum boost control with third harmonic injection (MBC-THI), maximum constant boost control (MCBC), and constant boost control with third harmonic injection (CBC-THI). All these mentioned PWM techniques are compared, and the converter opted in this paper is an enhanced ultrahigh gain active-switched quasi-Z-source inverter (EUHG-qZSI). The comparisons discussed in this brief are bridge stress, voltage gain, and voltage boost variation under each control strategy implementation. The theoretical and simulation evaluation for the abovementioned findings is presented in this paper, and the best PWM among them is maximum boost control (MBC).
Extrapulmonary Tuberculosis Leading to Abdominal Wall Mass in Young Patient
Authors: Karimi Mohadeseh , AtashAbParvar Ali
Published: February 2024

Background. Tuberculosis is a bacterial infection that is caused by Mycobacterium tuberculosis. Tuberculosis has arguably been the largest killer of humans historically, and it remains one of the most important infectious causes of death in the world. Tuberculosis can be classified into different forms and it manifests as pulmonary and out pulmonary, respectively, in 85% and 15% of cases. Only a few cases of tuberculosis with abdominal wall involvement have been reported. Case Presentation. Herein, we present a 27-year-old Persian woman, presented with asymmetric abdominal bulging in the right side of the periumbilical area since 6 months before admission that has no pain or secretion. The patient was oriented and not ill or toxic in general appearance. Vital signs were within normal ranges. An abdominal physical examination revealed a mobile, well-bordered, nontender mass 3 × 3 centimeter (cm) in diameter palpated in the right periumbilical area. The patient underwent surgery which revealed a cystic lesion that was carefully resected. In histopathology examination of the specimen resection, tuberculosis was confirmed. Conclusion. We report a rare case of extrapulmonary tuberculosis that was identified at the abdominal wall. Due to the high number of cases of TB and the development of extrapulmonary forms that can present in an unusual location as an abdominal wall which are difficult to diagnose, it is very important to keep in mind the differential diagnosis of tuberculosis.
Supplementary Table S3 from Genetic and Environmental Causes of Variation in an Automated Breast Cancer Risk Factor Based on Mammographic Textures
Authors: Ye Zhoufeng , Dite Gillian S. , Nguyen Tuong L. , MacInnis Robert J. , Schmidt Daniel F. , Makalic Enes , Al-Qershi Osamah M. , Nguyen-Dumont Tu , Goudey Benjamin , Stone Jennifer , Dowty James G. , Giles Graham G. , Southey Melissa C. , Hopper John L. , Li Shuai
Published: February 2024

Supplementary Table S3 shows that no evidence was found that the exponential, polynomial, linear models or the best-fit piecewise linear models gave a better fit than the age-constant models. There was no difference in the correlations between DZ pairs and non-twin sister pairs (P > 0.9). The MZ pair correlation was more than twice the correlation of DZ and non-twin sister pairs combined (P < 0.001). Therefore, the evidence supports that the familial correlations were constant regardless of the types of pairs; the MZ pair correlation was 0.52 (SE: 0.03), and the DZ and non-twin sister pair correlation was 0.16 (SE: 0.03).
Supplementary Table S1 from Unsatisfactory Fecal Immunochemical Tests for Colorectal Cancer Screening: Prevalence, Reasons, and Subsequent Testing
Authors: Liu Po-Hong , Nair Rasmi G. , Skinner Celette Sugg , Murphy Caitlin C. , Kim Eric J. , Ortiz Cynthia , Wang Lei , Hu Ellen , Lykken Jacquelyn M. , Levin Theodore R. , Green Beverly B. , Hahn Erin E. , Santini Noel , Halm Ethan A.
Published: February 2024

This table tabulates reasons for unsatisfactory FIT based on free-text responses entered by laboratory technician in EHR
Supplementary Figure S3 from Unsatisfactory Fecal Immunochemical Tests for Colorectal Cancer Screening: Prevalence, Reasons, and Subsequent Testing
Authors: Liu Po-Hong , Nair Rasmi G. , Skinner Celette Sugg , Murphy Caitlin C. , Kim Eric J. , Ortiz Cynthia , Wang Lei , Hu Ellen , Lykken Jacquelyn M. , Levin Theodore R. , Green Beverly B. , Hahn Erin E. , Santini Noel , Halm Ethan A.
Published: February 2024

This figure depicts reasons for unsatisfactory FIT based on type of FIT
Supplementary Figure S1 from Unsatisfactory Fecal Immunochemical Tests for Colorectal Cancer Screening: Prevalence, Reasons, and Subsequent Testing
Authors: Liu Po-Hong , Nair Rasmi G. , Skinner Celette Sugg , Murphy Caitlin C. , Kim Eric J. , Ortiz Cynthia , Wang Lei , Hu Ellen , Lykken Jacquelyn M. , Levin Theodore R. , Green Beverly B. , Hahn Erin E. , Santini Noel , Halm Ethan A.
Published: February 2024

This figure depicts CRC screening programs at Parkland over the study period
Supplementary Figure 2 from A Multiscale Spatiotemporal Epidemiological Analysis of Neighborhood Correlates of Triple-Negative Breast Cancer
Authors: Goldfinger Erica , Stoler Justin , Goel Neha
Published: February 2024

Figure S2. Distribution of local bivariate relationships between the present study’s cancer center data frame and the Florida Cancer Data Service’s (FCDS) breast cancer records. The map demonstrates predominantly positive linear local relationships between the two data sets for 534 census tracts in Miami-Dade County. Some of the strongest associations between the distributions of FCDS and institutional registry cases correspond to areas that were identified as TNBC hot spots (red oval). This further supports the likelihood that the observed spatiotemporal patterns were not geographical artefacts of the study population served by the hospital.
Supplementary Table 1 from Alcohol, Smoking, and Risks of Breast Cancer Recurrence and Mortality among Women with Luminal, Triple-Negative, and HER2-Overexpressing Breast Cancer
Authors: Loroña Nicole C. , Othus Megan , Malone Kathleen E. , Linden Hannah M. , Tang Mei-Tzu C. , Li Christopher I.
Published: February 2024

Supplementary Table 1 presents the risk of locoregional and distant breast cancer recurrence and risk of recurrence to bone, lung, and liver associated with alcohol use at diagnosis, for luminal, triple-negative (TN), and overall breast cancer.
Supplementary Table S4 from Sugar-Sweetened Beverages Consumption and Breast Cancer in Premenopausal and Postmenopausal Women
Authors: Garduño-Alanis Adriana , Ángeles-Llerenas Angélica , Sánchez-Zamorano Luisa María , Flores-Luna Lourdes , Flores-Aldana Mario , Torres-Mejía Gabriela
Published: February 2024

Supplementary Table S4 shows Sugar-sweetened beverages consumption and the risk of breast cancer model adjusted for healthy dietary index in Postmenopausal women.
Supplementary Table S1 from Sugar-Sweetened Beverages Consumption and Breast Cancer in Premenopausal and Postmenopausal Women
Authors: Garduño-Alanis Adriana , Ángeles-Llerenas Angélica , Sánchez-Zamorano Luisa María , Flores-Luna Lourdes , Flores-Aldana Mario , Torres-Mejía Gabriela
Published: February 2024

Supplementary Table S1 shows Sugar-sweetened beverages consumption and the risk of breast cancer model adjusted for kilocalories in Premenopausal women.
Supplementary Table S4 from Genetic Factors and Long-term Treatment-Related Neurocognitive Deficits, Anxiety, and Depression in Childhood Leukemia Survivors: An Exome-Wide Association Study
Authors: Petrykey Kateryna , Lippé Sarah , Sultan Serge , Robaey Philippe , Drouin Simon , Affret-Bertout Laurence , Beaulieu Patrick , St-Onge Pascal , Baedke Jessica L. , Yasui Yutaka , Hudson Melissa M. , Laverdière Caroline , Sinnett Daniel , Krajinovic Maja
Published: February 2024

Multivariable regression analysis for the Trail making test, female participants.
Supplementary Figure S2 from Genetic Factors and Long-term Treatment-Related Neurocognitive Deficits, Anxiety, and Depression in Childhood Leukemia Survivors: An Exome-Wide Association Study
Authors: Petrykey Kateryna , Lippé Sarah , Sultan Serge , Robaey Philippe , Drouin Simon , Affret-Bertout Laurence , Beaulieu Patrick , St-Onge Pascal , Baedke Jessica L. , Yasui Yutaka , Hudson Melissa M. , Laverdière Caroline , Sinnett Daniel , Krajinovic Maja
Published: February 2024

Manhattan plot for the mood disorders as measured by Moderate-Severe anxiety
Figure S3 from Potential for Cure by Stage across the Cancer Spectrum in the United States
Authors: Hubbell Earl , Clarke Christina A. , Smedby Karin E. , Adami Hans-Olov , Chang Ellen T.
Published: February 2024

Cure fraction (with 95% confidence interval indicated by error
bars) for selected cancer types by stage at diagnosis, restricted to cases who received
primary surgical therapy with curative intent (red) or without restriction (i.e., all cases,
blue), ages 40–79 years at diagnosis from 2006–2015, followed for mortality through
2020, Surveillance, Epidemiology, and End Results (SEER) 17 registries
Supplementary Table S3 from Community-Level Factors Associated with Hepatocellular Carcinoma Incidence and Mortality: An Observational Registry Study
Authors: Mezzacappa Catherine , Rossi Raiza , Jaffe Ariel , Taddei Tamar H. , Strazzabosco Mario
Published: February 2024

Supplementary Table S3: Interrupted time series analyses of HCC incidence before and after introduction of DAA for HCV stratified by community type
Supplementary Figure S5 from Trends of Prostate Cancer Morbidity in Low-Incidence Countries from 1990–2019
Authors: Jiang Jinjiang , Chen Bo , Tang Bo , Yang Jie , Zhang Ting , Li Jinze , Tan Daqing , Wei Qiang
Published: February 2024

Supplementary Figure S5 shows the age-specific burden of prostate cancer among Mozambique, Myanmar, Nepel, Pakistan, Sri Lanka, Sudan in 1990 and 2019.(a) Sudan exhibits a consistent age structure for prostate cancer in both 1990 and 2019, with the 90-94 years years age group having the highest ASIR in both years. (b) Mozambique exhibits a consistent age structure for prostate cancer in both 1990 and 2019, with the 90-94 years years age group having the highest ASIR in both years. (c) Sri Lanka exhibits a consistent age structure for prostate cancer in both 1990 and 2019, with the 95+ years age group having the highest ASIR in both years. (d) Nepal exhibits a consistent age structure for prostate cancer in both 1990 and 2019, with the 95+ years age group having the highest ASIR in both years. (e) Minor variations in the age distribution of prostate cancer in Pakistan were observed between 1990 and 2019. In 1990, the highest ASIR was observed in the 90-94 years age group, while by 2019, it had shifted to the 95+ years age group. (f) Myanmar exhibits a consistent age structure for prostate cancer in both 1990 and 2019, with the 90-94 years years age group having the highest ASIR in both years.
Supplementary Figure S12 from Community-Level Factors Associated with Hepatocellular Carcinoma Incidence and Mortality: An Observational Registry Study
Authors: Mezzacappa Catherine , Rossi Raiza , Jaffe Ariel , Taddei Tamar H. , Strazzabosco Mario
Published: February 2024

Supplementary Figure S12: Correlation between average annual cases of HCC (y-axis) and proportion of adults with obesity (x-axis).
Supplementary Table 3 from Increase in the Life Expectancy of Patients with Cancer in the United States
Authors: Devasia Theresa P. , Howlader Nadia , Dewar Ron A. , Stevens Jennifer L. , Mittu Karen , Mariotto Angela B.
Published: February 2024

Supplementary table containing model fit criteria for final model for each cancer site.
Supplementary Table 2 from Increase in the Life Expectancy of Patients with Cancer in the United States
Authors: Devasia Theresa P. , Howlader Nadia , Dewar Ron A. , Stevens Jennifer L. , Mittu Karen , Mariotto Angela B.
Published: February 2024

Supplementary table containing sensitivity analysis results for males aged 55 at diagnosis.
Supplementary Materials and Methods from Increase in the Life Expectancy of Patients with Cancer in the United States
Authors: Devasia Theresa P. , Howlader Nadia , Dewar Ron A. , Stevens Jennifer L. , Mittu Karen , Mariotto Angela B.
Published: February 2024

Supplementary materials and methods outline SAS code used to fit flexible parametric survival model. Document includes a simple example along with a link to the Github repository containing full macro code and worked examples.
Supplementary Figure 8 from Increase in the Life Expectancy of Patients with Cancer in the United States
Authors: Devasia Theresa P. , Howlader Nadia , Dewar Ron A. , Stevens Jennifer L. , Mittu Karen , Mariotto Angela B.
Published: February 2024

Timeline of treatment advances for melanoma showing treatments that received FDA approval between 1975 and 2018.
Supplementary Figure 4 from Increase in the Life Expectancy of Patients with Cancer in the United States
Authors: Devasia Theresa P. , Howlader Nadia , Dewar Ron A. , Stevens Jennifer L. , Mittu Karen , Mariotto Angela B.
Published: February 2024

Timeline of treatment advances for CML showing treatments that received FDA approval between 1975 and 2018.
Supplementary Figure S2 from Decline in the Incidence of Distant Recurrence of Breast Cancer: A Population-Based Health Record Linkage Study, Australia 2001–2016
Authors: Lord Sarah J. , Daniels Benjamin , O'Connell Dianne L. , Kiely Belinda E. , Beith Jane , Smith Andrea L. , Pearson Sallie-Anne , Chiew Kim-Lin , Bulsara Max K. , Houssami Nehmat
Published: February 2024

Supplementary Figure S2: Study flowchart showing the number of women with a first diagnosis of primary invasive breast cancer in New South Wales in 2001-2002 and 2006-2007, number included in the study cohorts, and reasons for exclusions.
Supplementary Table S5 from The Influence of Smoking and Occupational Risk Factors on DNA Methylation in the AHRR and F2RL3 Genes
Authors: Pelland-St-Pierre Laura , Pham Michael C. , Nguyen Alice Quynh Huong , Pasquet Romain , Taylor Sherryl A. , Bosson-Rieutort Delphine , Koushik Anita , Ho Vikki
Published: February 2024

Supplementary Table S5 shows regression coefficients that denote the difference in average DNA methylation level, as derived from the mean methylation ratios across all estimated CpG sites in the F2RL3 gene, and their associated 95%CI relative to the reference group. Multivariable models included adjustment for age, sex (not for stratified models), phase of blood sampling, education level, ethnicity, and smoking (CSI - cumulative smoking index). FWI of 0 was used to classify those as never exposed, >0-population median value as ‘Low exposure’ and ≥population median value as ‘High exposure.’
Supplementary Table S2 from The Influence of Smoking and Occupational Risk Factors on DNA Methylation in the AHRR and F2RL3 Genes
Authors: Pelland-St-Pierre Laura , Pham Michael C. , Nguyen Alice Quynh Huong , Pasquet Romain , Taylor Sherryl A. , Bosson-Rieutort Delphine , Koushik Anita , Ho Vikki
Published: February 2024

Supplementary Table S2 shows regression coefficients that denote the difference in average DNA methylation level, as derived from the mean methylation ratios across all estimated CpG sites in the F2RL3 gene, and their associated 95%CI relative to the reference group. Multivariable models included adjustment for age, sex (not for stratified models), phase of blood sampling, education level, ethnicity, and smoking (CSI - cumulative smoking index). A probability of exposure of 0% was categorized as unexposed; “Possibly exposed” if the probability of exposure was >0% and <25% and; “Exposed” to a given agent if the probability of exposure was ≥25%.
Supplementary Figure S1 from The Influence of Smoking and Occupational Risk Factors on DNA Methylation in the AHRR and F2RL3 Genes
Authors: Pelland-St-Pierre Laura , Pham Michael C. , Nguyen Alice Quynh Huong , Pasquet Romain , Taylor Sherryl A. , Bosson-Rieutort Delphine , Koushik Anita , Ho Vikki
Published: February 2024

Supplementary Figure S1 shows, for each graph, the effect estimate and the 95% CI plotted across all 33 CpG sites in the AHRR gene. The dotted black line represents the null. For CSI, the interpretation of the effect estimate is the change in DNA methylation levels per standard
deviation increase in CSI. For smoking status (i.e., former and current smokers), the interpretation of the effect estimate is the
difference in mean methylation level relative to never smokers (reference group). Multivariable models included adjustment for
age, sex, phase of blood sampling, education level, and ethnicity. * denotes a p-value < 0.05.
Data from Metabolic Syndrome and the Risk of Ductal Carcinoma In Situ of the Breast in the UK Biobank
Authors: Peila Rita , Rohan Thomas E.
Published: February 2024

AbstractBackground:
Metabolic syndrome (MetS), defined by the presence of three of more metabolic dysregulations such as hyperlipidemia, hyperinsulinemia, central obesity, and hypertension, has been associated with increased risk of cardiovascular disease, diabetes, and various cancers, including invasive breast cancer (IBC). Whether MetS is a risk factor for ductal carcinoma in situ of the breast (DCIS), a nonobligate precursor of IBC, remains unknown.
Methods:
A total of 198,748 women ages 40 to 69 years, DCIS- and IBC-free at enrolment in UK Biobank, were included in the current study. Multivariable-adjusted Cox proportional hazards models were used to estimate the association between MetS and DCIS.
Results:
A total of 1,251 DCIS cases were ascertained during an average follow-up of 11.4 years. There was no association between MetS and the risk of DCIS overall, or by menopausal status. Analysis of individual components of MetS showed an association between central obesity (waist circumference ≥88 cm) and increased DCIS risk in postmenopausal women.
Conclusions:
In this prospective study, we found no association between MetS and DCIS risk.
Impact:
The study findings do not support an association between MetS and this breast cancer precursor.
Data from Community-Level Factors Associated with Hepatocellular Carcinoma Incidence and Mortality: An Observational Registry Study
Authors: Mezzacappa Catherine , Rossi Raiza , Jaffe Ariel , Taddei Tamar H. , Strazzabosco Mario
Published: February 2024

AbstractBackground:
Hepatocellular carcinoma (HCC) incidence and outcomes vary across populations in the United States, but few studies evaluate local drivers of observed disparities. We measured HCC incidence at the community level and assessed community-level HCC risk factors with the goal of informing resource allocation to improve early case detection, which is associated with improved outcomes.
Methods:
Clinical and demographic data including census tract of residence for all adults diagnosed with HCC in the Connecticut Tumor Registry between 2008 and 2019 were combined with publicly available U.S. Census and Centers for Disease Control and Prevention (CDC) data at the ZIP Code tabulation area (ZCTA) level. The average annual incidence of HCC was calculated for each ZCTA and associations between community-level characteristics, HCC incidence, stage at diagnosis, and survival were evaluated.
Results:
Average annual HCC incidence during the study period was 8.9/100,000 adults and varied from 0 to 97.7 per 100,000 adults by ZCTA. At the community level, lower rates of high school graduation, higher rates of poverty, and rural community type were associated with higher HCC incidence. Persons with HCC living in the highest incidence ZCTAs were diagnosed at a younger age and were less likely to be alive at 1, 2, and 5 years after diagnosis.
Conclusions:
Community-level socioeconomic factors are strongly associated with HCC incidence and survival in Connecticut.
Impact:
This reproducible geo-localization approach using cancer registry, Census, and CDC data can be used to identify communities most likely to benefit from health system investments to reduce disparities in HCC.