bluuebunny/crossref_metadata_2025 huggingface dataset:
ChemInform Abstract: A Missing Oxidation‐State Level in the Family of Polyoxo(azide)octadecavanadate(IV/V) Clusters: Synthesis, Structure and Antitumoural Properties of [VIV11VV7O44 (N3)]10‐ in a Sodium Containing‐3D Architecture.
Authors: Roubatis Leonidas , Anastasiadis Nikolaos C. , Paratriantafyllopoulou Constantina , Moushi Eleni , Tasiopoulos Anastasios J. , Karkabounas Spyridon Ch. , Veltsistas Panayotis G. , Perlepes Spyros P. , Evangelou Angelos M.
Published: July 2016

Dark khaki‐green crystals of [V18Na10O44(N3) (H2O)32]·H2O are obtained from aqueous mixtures of VOSO4, NaN3, H2O2, and NaOH (70 °C, 1 h, 35—40% yield).
ChemInform Abstract: Hydrazine‐Hydrothermal Syntheses, Characterizations and Photoelectrochemical Properties of Two Quaternary Chalcogenidoantimonates(III) BaCuSbQ3 (Q: S, Se).
Authors: Liu Chang , Hou Peipei , Chai Wenxiang , Tian Jiawei , Zheng Xuerong , Shen Yaying , Zhi Mingjia , Zhou Chunmei , Liu Yi
Published: July 2016

The isostructural compounds BaCuSbS3 (I) and BaCuSbSe3 (II) are prepared by hydrazine‐hydrothermal reaction of a 1:1:1:0.5:2.5(2.0) molar mixture of Ba(OAc)2, KOH, Cu, Sb2S3, and S (Se) to which N2H4·H2O is given (autoclave, 160 °C, 6 d).
ChemInform Abstract: Rh‐Catalyzed 1,4‐Addition of Triallyl(aryl)silanes to α,β‐Unsaturated Carbonyl Compounds.
Authors: Kamei Toshiyuki , Uryu Mizuho , Shimada Toyoshi
Published: July 2016

Three allyl groups on silicon are essential for the successful 1,4‐addition reaction to α,β‐unsaturated ketones and esters.
ChemInform Abstract: Solvent‐Free Regioselective Synthesis of Novel Isoxazoline and Pyrazoline N‐Substituted Saccharin Derivatives under Microwave Irradiation.
Authors: Saber Aziza , Driowya Mohsine , Alaoui Soukaina , Marzag Hamid , Demange Luc , Alvarez Eleuterio , Benhida Rachid , Bougrin Khalid
Published: July 2016

Regioselective synthesis of novel isoxazoline and pyrazoline derivatives of N‐substituted saccharine of type (V) and (VII) are studied.
ChemInform Abstract: Sequential Prins/Pinacol Strategy for the Stereoselective Synthesis of Spiro‐β‐tetralones.
Authors: Reddy B. V. Subba , Raju N. Prudhvi , Reddy B. Jagan Mohan , Sridhar B.
Published: July 2016

A convenient one‐pot protocol is developed for the condensation reaction of enediol (I) with aldehydes or ketones followed by Prins cyclization and pinacol rearrangement to afford spiro‐β‐tetralones.
ChemInform Abstract: Organocatalytic One‐Pot Synthesis of Functionalized 1,3‐Oxathiolanes and 1,3‐Thiazolidines.
Authors: Ghazanfarpour‐Darjani Majid , Khodakarami Alieh
Published: July 2016

A conjugated base of nitromethane is employed as potential organocatalyst to promote cyclization reactions between strained heterocyclic compounds and heterocumulenes.
ChemInform Abstract: Organoselenium‐Catalyzed Oxidative Ring Expansion of Methylenecyclopropanes with Hydrogen Peroxide.
Authors: Yu Lei , Chen Fenglin , Ding Yuanhua
Published: July 2016

The title reaction gives cyclobutanones selectively under mild conditions.
ChemInform Abstract: Anodic Oxidation of Caffeine and Theophylline in Glacial Acetic Acid.
Authors: Quintanilla Gloria , Usarralde Angela , Perez Ivan , Gargiulo Maria L. , Yakupoglu Goekce , Martin Avelino , Barba Fructuoso
Published: July 2016

The anodic oxidation of caffeine at a controlled potential with a glassy‐carbon anode and a platinum cathode with glacial acetic acid/sodium acetate electrolyte yields a spiro compound (III) and purinyl acetate (IV).
ChemInform Abstract: Sodium Bromide‐Catalyzed Oxidation of Secondary Benzylic Alcohols Using Aqueous Hydrogen Peroxide as Terminal Oxidant.
Authors: Komagawa Hiromi , Maejima Yukako , Nagano Takashi
Published: July 2016

The scalable reaction has a broad substrate scope and tolerates various functional groups including primary hydroxy groups.
ChemInform Abstract: Cobalt(III)‐Catalyzed C—H Halogenation of 6‐Arylpurines: Facile Entry into Arylated, Sulfenylated and Alkoxylated 6‐Arylpurines.
Authors: Pawar Amit B. , Lade Dhanaji M.
Published: July 2016

The purine moiety acts as directing group in this iodination or bromination reaction with NIS or NBS.
ChemInform Abstract: Reduction of Aryl Halides into Arenes with 2‐Propanol Promoted by a Substoichiometric Amount of a tert‐Butoxy Radical Source.
Authors: Ueno Ryota , Shimizu Takashi , Shirakawa Eiji
Published: July 2016

The reaction has a broad substrate scope, thus tolerating e.g. heteroarenes and chloro or alkyne functionalized arenes, and may be adjusted to the transformation of sensitive bromoarenes, including alkene‐, keto‐ and cyano‐group containing ones.
ChemInform Abstract: Enantioselective Decarboxylative Arylation of α‐Amino Acids via the Merger of Photoredox and Nickel Catalysis.
Authors: Zuo Zhiwei , Cong Huan , Li Wei , Choi Junwon , Fu Gregory C. , MacMillan David W. C.
Published: July 2016

An enantioselective, decarboxylative C(sp3)—C(sp3) cross‐coupling reaction of α‐amino acids with aryl halides by synergistic iridium‐photoredox and nickel catalysis is presented.
ChemInform Abstract: Facile Preparation of Functionalized 1‐Substituted Cycloalkenes via an Iodine Atom Transfer Radical Addition—Elimination Process.
Authors: Meyer Daniel , Vin Estelle , Wyler Benjamin , Lapointe Guillaume , Renaud Philippe
Published: July 2016

A scalable conversion of methylenecycloalkenes into 1‐substituted cycloalkenes (endo product), which are isolated together with minor amounts of their cycloalkylidene isomers (exo product), is described.
ChemInform Abstract: Three‐Component Reaction Between N‐Methylimidazole and Activated Acetylenes in the Presence of Kojic Acid or 8‐Hydroxyquinoline as CH‐Acids
Authors: Pahlavan Pedram , Hassanabadi Alireza
Published: July 2016

affording 2,3‐dihydroimidazoles with good yields under neutral reaction conditions
ChemInform Abstract: α‐Amino Aldehydes as Readily Available Chiral Aldehydes for Rh‐Catalyzed Alkyne Hydroacylation.
Authors: Hooper Joel F. , Seo Sangwon , Truscott Fiona R. , Neuhaus James D. , Willis Michael C.
Published: July 2016

α‐Amino aldehydes, incorporating a methylthiomethyl protecting group on nitrogen, are efficient substrates in Rh‐catalyzed alkyne hydroacylation reactions.
ChemInform Abstract: [1 + 1 + 1] Cyclotrimerization for the Synthesis of Cyclopropanes.
Authors: Manna Srimanta , Antonchick Andrey P.
Published: July 2016

The copper‐catalyzed [1+1+1] cyclotrimerization of acetophenone derivatives affording a wide range of highly substituted cyclopropanes under mild reaction condition is reported for the first time.
ChemInform Abstract: An Air‐Stable Half‐Sandwich RuII Complex as an Efficient Catalyst for [3 + 2] Annulation of 2‐Arylcyclo‐2‐enones with Alkynes.
Authors: Zhao Yinsong , He Zhen , Li Shiqing , Tang Junbin , Gao Ge , Lan Jingbo , You Jingsong
Published: July 2016

A novel ruthenium complex HSRC is prepared and successfully applied for the synthesis of spiro carbocyclic indenes via a [3 + 2] annulation strategy.
ChemInform Abstract: Rhodium‐Catalyzed Selective Mono‐ and Diamination of Arenes with Single Directing Site “On Water”.
Authors: Ali Md Ashif , Yao Xiayin , Li Guigen , Lu Hongjian
Published: July 2016

The same conditions can be used for the mono‐ and the diamination step.
ChemInform Abstract: Copper‐Catalyzed Intermolecular Hydroamination of Internal Alkynes with Anilines and Amines.
Authors: Ishikawa Tomoki , Sonehara Taro , Minakawa Maki , Kawatsura Motoi
Published: July 2016

Alkynes bearing a terminal trifluoromethyl group are treated with aryl amines under conditions A), i.e.
ChemInform Abstract: High‐Yielding Aqueous Synthesis of Chloroacetophenones and Aroyl Chlorohydrins.
Authors: Zhang Xixi , Liu Lei , Li Chunbao
Published: July 2016

The title products are obtained without further purification.
ChemInform Abstract: Polystyrene Resin‐Supported CuI‐Cryptand 22 Complex: A Highly Efficient and Reusable Catalyst for the Formation of Aryl—Sulfur Bonds in Aqueous Media.
Authors: Rezaei Nasrin , Movassagh Barahman
Published: July 2016

The cross‐coupling reaction of aryl halides and thiols in aqueous media is efficiently catalyzed by the air and moisture stable title catalyst (PCU).
ChemInform Abstract: Metal‐Free Direct Nucleophilic Perfluoroalkylthiolation with Perfluoroalkanesulfenamides.
Authors: Glenadel Quentin , Bordy Mathieu , Alazet Sebastien , Tlili Anis , Billard Thierry
Published: July 2016

Anions generated in situ from perfluoroalkanesulfenamides undergo direct metal‐free nucleophilic substitution reactions with a wide range of alkyl halides to form the corresponding products.
ChemInform Abstract: Copper‐Catalyzed Oxidative α‐Ketoacylations of Sulfoximines with Aryl Methyl Ketones and Dioxygen as Terminal Oxidant.
Authors: Cheng Hanchao , Bolm Carsten
Published: July 2016

The reaction has a broad substrate scope and delivers the products in moderate to high yields.
ChemInform Abstract: Novel and Potent Lewis Acid Catalyst: Br2‐Catalyzed Friedel—Crafts Reactions of Naphthols with Aldehydes.
Authors: Liang Deqiang , Li Jingjing , Li Yanni , Wang Baoling , Cheng Ping , Luo Sha
Published: July 2016

It is shown that Br2 can act as a catalyst in Friedel—Crafts reaction of naphthols.
ChemInform Abstract: An Efficient Approach to Bis‐benzoquinonylmethanes on Water under Catalysis of the Bio‐Derived O‐Carboxymethyl Chitosan.
Authors: Asghari‐Haji Fatereh , Rad‐Moghadam Kurosh , Mahmoodi Nosrat O.
Published: July 2016

The title compounds are efficiently prepared under mild and metal‐free conditions by reaction of the naphthalene‐dione derivative with various aromatic aldehydes using carboxymethyl chitosan as a green, available, cheap, and water‐soluble bio‐derived catalyst.
ChemInform Abstract: Chemoselective Cross‐Coupling Reaction of Sodium Sulfinates with Phenols under Aqueous Conditions.
Authors: Xiao Fuhong , Chen Shuqing , Tian Jinxin , Huang Huawen , Liu Yuejin , Deng Guo‐Jun
Published: July 2016

Stable and readily available sodium sulfinates are used as the sulfur source.
ChemInform Abstract: Intermolecular C—N Cross‐Coupling Reactions Catalyzed by Tetra‐n‐butylammonium Iodide: Synthesis of Allylic N‐Heterocycles.
Authors: Lv Yunhe , Sun Kai , Wang Tingting , Wu Yingtao , Li Gang , Pu Weiya , Mao Shukuan
Published: July 2016

An operationally simple method for the oxidative coupling of cyclohexene to a variety of N‐heterocycles is demonstrated.
ChemInform Abstract: Spirocyclic Sultam and Heterobiaryl Synthesis Through Rh‐Catalyzed Cross‐Dehydrogenative Coupling of N‐Sulfonyl Ketimines and Thiophenes or Furans.
Authors: Mei Shu‐Tao , Liang Hong‐Wen , Teng Bin , Wang Nan‐Jin , Shuai Li , Yuan Yi , Chen Ying‐Chun , Wei Ye
Published: July 2016

Depending on the thiophene or furan derivative used the scalable method provides either spirocyclic sultams or heterobiaryls.
ChemInform Abstract: Amination of 3‐Substituted Benzofuran‐2(3H)‐ones Triggered by Single‐Electron Transfer.
Authors: Yang Chen , Liu Yang , Yang Jin‐Dong , Li Yi‐He , Li Xin , Cheng Jin‐Pei
Published: July 2016

Various 3‐arylbenzofuran‐2(3H)ones are oxidatively aminated with dinitrobenzenesulfonic carbamates in moderate to high yields.
ChemInform Abstract: Transition‐Metal Free Thiocyanooxygenation of Functionalized Alkenes: Facile Routes to SCN‐Containing Dihydrofurans and Lactones.
Authors: Guo Li‐Na , Gu Yu‐Rui , Yang Hua , Hu Jie
Published: July 2016

A tandem cyclization of olefins with thiocyanate salts under mild conditions affords the title compounds.
ChemInform Abstract: Fast Functionalization of (7‐Aza)indoles Using Continuous Flow Processes.
Authors: D'Attoma Joseph , Cozien Gregoire , Brun Pierre Louis , Robin Yves , Bostyn Stephane , Buron Frederic , Routier Sylvain
Published: July 2016

The functionalization of the title compounds proceeds in three steps, namely iodination, nitrogen protection, and copper‐free Sonogashira cross‐coupling reaction by using a continuous flow set‐up.
ChemInform Abstract: Silver Catalyzed Domino Aza‐Annulation/Diels—Alder Cyclization of 2‐Ene‐Yne Anilines: A Facile One‐Pot Access to Carbazole, Dihydrocarbazole and Tetrahydrocarbazole Frameworks.
Authors: Krishna Namballa Hari , Saraswati A Prasanth , Sathish Manda , Shankaraiah Nagula , Kamal Ahmed
Published: July 2016

The domino aza‐annulation/Diels—Alder cyclization of 2‐ene‐yne anilines (I) with acetylenedicarboxylate leads to desired carbazoles (III).
ChemInform Abstract: Cyclization of Alkyne—Azide with Isonitrile/CO via Self‐Relay Rhodium Catalysis.
Authors: Zhang Zhen , Xiao Fan , Huang Baoliang , Hu Jincheng , Fu Bin , Zhang Zhenhua
Published: July 2016

Pyrrolo[2,3‐b]indoles are synthesized using the title reaction via a tandem nitrene transformation and aza‐Pauson—Khand cyclization.
ChemInform Abstract: Amine Directed Pd(II)‐Catalyzed C—H Activation‐Intramolecular Amination of N‐Het(aryl)/Acyl Enaminonitriles and Enaminones: An Approach Towards Multisubstituted Indoles and Heterofused Pyrroles.
Authors: Yugandar Somaraju , Konda Saidulu , Ila Hiriyakkanavar
Published: July 2016

The reaction is characterized by high regioselectivity and functional group diversity.
ChemInform Abstract: One‐Pot Synthesis of Oxazolidine Derivatives by [3 + 2]‐Annulation Reactions of 1‐Tosyl‐2‐phenyl/alkylaziridines with Aryl Epoxides.
Authors: Pandey Ashok Kumar , Banerjee Prabal
Published: July 2016

A BF3·OEt2‐promoted reaction of aziridines and aldehydes generated in situ from epoxides is developed to furnish various functionalized oxazolidines.
ChemInform Abstract: A Base Promoted Multigram Synthesis of Aminoisoxazoles: Valuable Building Blocks for Drug Discovery and Peptidomimetics.
Authors: Chalyk Bohdan A. , Kandaurova Inna Y. , Hrebeniuk Kateryna V. , Manoilenko Olga V. , Kulik Irene B. , Iminov Rustam T. , Kubyshkin Vladimir , Tverdokhlebov Anton V. , Ablialimov Osman K. , Mykhailiuk Pavel K.
Published: July 2016

The reactions are carried out under metal‐free conditions.
ChemInform Abstract: A Tandem Prins Spirocyclization for the Stereoselective Synthesis of Tetrahydrospiro[chroman‐2,4′‐pyran] Derivatives.
Authors: Subba Reddy B. V. , Hanuman Reddy V. , Medaboina Durgaprasad , Sridhar B. , Rami Reddy Y. V.
Published: July 2016

Single diastereomers of title compounds are obtained by the title reaction with aryl or cinnamyl aldehydes.
ChemInform Abstract: Tandem Arylation/Friedel—Crafts Reaction of O‐Hydroxy Bisbenzylic Alcohols with Diaryliodonium Salts: One Pot Synthesis of Unsymmetrical 9‐Arylxanthenes.
Authors: Mao Song , Hua Zerui , Wu Xunshen , Yang Yang , Han Jianwei , Wang Limin
Published: July 2016

An efficient one‐pot method for the reaction of o‐hydroxy bisbenzylic alcohols and diaryliodonium salts is presented.
ChemInform Abstract: A Convenient Route to Symmetrically and Unsymmetrically Substituted 3,5‐Diaryl‐2,4,6‐trimethylpyridines via Suzuki—Miyaura Cross‐Coupling Reaction.
Authors: Blachut Dariusz , Szawkalo Joanna , Czarnocki Zbigniew
Published: July 2016

Under optimized conditions, a series of title compounds (III) and (VI) are synthesized via cross‐coupling reaction.
ChemInform Abstract: Palladium‐Catalyzed Divergent Arylation with Triazolopyridines: One‐Pot Synthesis of 6‐Aryl‐2‐α‐styrylpyridines.
Authors: Moon Youngtaek , Kwon Soonhyung , Kang Dahye , Im Honggu , Hong Sungwoo
Published: July 2016

The title pyridines are successfully prepared by two different catalytic arylations performed in one‐pot with a single Pd catalyst using two different bases.
ChemInform Abstract: Organocatalytic One‐Pot Asymmetric Synthesis of 2‐Aryl‐2,3‐dihydro‐4‐quinolones.
Authors: Pan Gao‐Fei , Su Li , Zhang Yan‐Lei , Guo Shi‐Huan , Wang Yong‐Qiang
Published: July 2016

The reaction is conducted under environmentally benign conditions and gives the corresponding quinolines with up to 99% enantioselective excess.
ChemInform Abstract: Chiral Triazoles in Anion‐Binding Catalysis: New Entry to Enantioselective Reissert‐Type Reactions.
Authors: Zurro Mercedes , Asmus Soeren , Bamberger Julia , Beckendorf Stephan , Garcia Mancheno Olga
Published: July 2016

The Reissert‐type dearomatization of isoquinoline derivatives proceeds in high yields and moderate enantioselectivities.
ChemInform Abstract: Acid‐Catalyzed Multicomponent Tandem Cyclizations: Access to Polyfunctional Dihydroindolizino[8,7‐b]indoles.
Authors: Cai Qun , Li Deng‐Kui , Zhou Rong‐Rong , Shu Wen‐Ming , Wu Yan‐Dong , Wu An‐Xin
Published: July 2016

Simple, readily available starting materials are used for the preparation of the desired alkaloid scaffold under metal‐free conditions A) or B).
ChemInform Abstract: Synthesis of Enantiopure Piperazines via Asymmetric Lithiation—Trapping of N‐Boc Piperazines: Unexpected Role of the Electrophile and Distal N‐Substituent.
Authors: Firth James D. , O'Brien Peter , Ferris Leigh
Published: July 2016

Yield and stereoselectivity in these reactions are controlled by the electrophile and the distal N‐substituent of piperazine.
ChemInform Abstract: The Synthesis of Multifunctionalized 1,3‐Oxazin‐4‐ones from Donor—Acceptor Cyclopropanes.
Authors: Smith Robert J. , Mills Daniel A. , Nhu Duong , Tan Eng Wui , Lucas Nigel T. , Hawkins Bill C.
Published: July 2016

A reliable but low‐yielding protocol for preparation of oxazinones from simple, readily available starting material is presented.
ChemInform Abstract: Oxidative Functionalization of Styrenes: Synthesis of 1,3,5‐Triazines from Styrenes via Tandem Cyclization with Amidines.
Authors: Tiwari Abhishek R. , Bhanage Bhalchandra M.
Published: July 2016

An efficient method is presented for a transition metal and solvent‐free reaction of easily available styrenes with amidines leading to various triazines.
ChemInform Abstract: Gold(I)‐Catalyzed Inter‐ and Intramolecular Additions of Carbonyl Compounds to Allenenes.
Authors: Jimenez Tania , Carreras Javier , Ceccon Julien , Echavarren Antonio M.
Published: July 2016

A series of allenenes bearing an additional 11‐oxo function is subjected to either conditions A) or B) containing a gold catalyst.
ChemInform Abstract: A Fluorination/Aryl Migration/Cyclization Cascade for the Metal‐Free Synthesis of Fluoro‐Benzoxazepines.
Authors: Ulmer Anna , Brunner Christoph , Arnold Andreas M. , Poethig Alexander , Gulder Tanja
Published: July 2016

The efficient, regioselective method is based on an operationally simple fluorination of readily available, structurally diverse styrene derivatives with a hypervalent iodine(III) fluoro reagent.
ChemInform Abstract: One‐Pot Suzuki Coupling of Aromatic Amines via Visible Light Photocatalyzed Metal Free Borylation Using t‐BuONO at Room Temperature.
Authors: Ahammed Sabir , Nandi Shiny , Kundu Debasish , Ranu Brindaban C.
Published: July 2016

This metal free borylation shows good functional group tolerance and provides aryl boronates in high yields.
ChemInform Abstract: Copper‐Catalyzed trans‐Hydroboration of Terminal Aryl Alkynes: Stereodivergent Synthesis of Alkenylboron Compounds.
Authors: Jang Won Jun , Lee Woo Lim , Moon Jong Hun , Lee Jin Yong , Yun Jaesook
Published: July 2016

Using 2 different catalyst combinations, either (Z)‐ oder (E)‐configurated title compounds are available.
ChemInform Abstract: Gold vs Rhodium Catalysis: Tuning Reactivity Through Catalyst Control in the C—H Alkynylation of Isoquinolones.
Authors: Shaikh Aslam C. , Shinde Dinesh R. , Patil Nitin T.
Published: July 2016

Conditions for the gold or rhodium catalyzed alkynylation of isoquinolones are developed allowing for the site‐selective C‐4 or C‐8 functionalization, respectively.
ChemInform Abstract: Rhodium(I)‐Catalyzed Highly Enantioselective Insertion of Carbenoid into Si—H: Efficient Access to Functional Chiral Silanes.
Authors: Chen Diao , Zhu Dong‐Xing , Xu Ming‐Hua
Published: July 2016

α‐Silyl esters and phosphonates are prepared under mild reaction conditions and with excellent enantioselectivities starting from α‐diazoester and phosphonates, resp.
ChemInform Abstract: Substituent‐Controlled Chemoselective Cleavage of C=C or C(sp2)—C(CO) Bond in α,β‐Unsaturated Carbonyl Compounds with H‐Phosphonates Leading to β‐Ketophosphonates.
Authors: Zhou Yao , Rao Changqing , Mai Shaoyu , Song Qiuling
Published: July 2016

β‐Ketophosphonates are obtained via retro‐HWE reaction from α,β‐unsaturated carbonyl compounds and H‐phosphonates.
ChemInform Abstract: A Rapid One‐Pot Five Component Sequential Access to Novel Imidazo[2,1‐b]thiazinyl‐α‐aminophosphonates.
Authors: Kaur Tanpreet , Saha Debasmita , Singh Neetu , Singh Udai P. , Sharma Anuj
Published: July 2016

The two‐step sequential Groebke—Blackburn—Bienayme and Kabachnik—Fields reaction gives access to novel bisheterocyclic scaffolds through a microwave‐assisted one‐pot method.
ChemInform Abstract: Iridium‐Catalyzed Enantioselective Indole Cyclization: Application to the Total Synthesis and Absolute Stereochemical Assignment of (‐)‐Aspidophylline A.
Authors: Jiang Shi‐Zhi , Zeng Xue‐Yi , Liang Xiao , Lei Ting , Wei Kun , Yang Yu‐Rong
Published: July 2016

A highly enantioselective indole allylic alkylation iminium cyclization cascade is developed and successfully applied as a key step in the total synthesis of (‐)‐aspidophylline A (VII).
ChemInform Abstract: Glycosylation of Nucleosides.
Authors: Zhang Yonglian , Knapp Spencer
Published: July 2016

Optimized conditions for the O‐glycosylation of nucleoside hydroxyls are developed.
ChemInform Abstract: A New Monoacylglycerol from the Fruiting Bodies of Gymnopilus spectabilis.
Authors: Suh Won Se , Lee Seoung Rak , Kim Chung Sub , Moon Eunjung , Kim Sun Yeou , Choi Sang Un , Kang Ki Sung , Lee Kang Ro , Kim Ki Hyun
Published: July 2016

The new monoacylglycerol (I) is isolated along with five known compounds.
ChemInform Abstract: Well‐Faceted Noble‐Metal Nanocrystals with Nonconvex Polyhedral Shapes
Authors: Chen Qiaoli , Jia Yanyan , Xie Shuifen , Xie Zhaoxiong
Published: July 2016

Review: structural characteristics, synthetic methods and applications; 99 refs.
ChemInform Abstract: Fundamentals and Catalytic Applications of CeO2‐Based Materials
Authors: Montini Tiziano , Melchionna Michele , Monai Matteo , Fornasiero Paolo
Published: July 2016

Review: 660 refs.
ChemInform Abstract: Recent Developments of Iron Pincer Complexes for Catalytic Applications
Authors: Bauer Gerald , Hu Xile
Published: July 2016

Review: 95 refs.
ChemInform Abstract: Homogeneous Rhodium(I)‐Catalysis in de novo Heterocycle Syntheses
Authors: Neuhaus James D. , Willis Michael C.
Published: July 2016

Review: [133 refs.
ChemInform Abstract: Cooperative Photoredox Catalysis
Authors: Lang Xianjun , Zhao Jincai , Chen Xiaodong
Published: July 2016

Review: 52 refs.
ChemInform Abstract: Huisgen′s Cycloaddition Reactions: A Full Perspective
Authors: Heravi Majid M. , Tamimi Mehrnoush , Yahyavi Hoda , Hosseinnejad Tayebeh
Published: July 2016

Review: 415 refs.
ChemInform Abstract: Alkenylation of Arenes and Heteroarenes with Alkynes
Authors: Boyarskiy Vadim P. , Ryabukhin Dmitry S. , Bokach Nadezhda A. , Vasilyev Aleksander V.
Published: July 2016

Review: 445 refs.
ChemInform Abstract: Solubility‐Driven Lead Optimization: Recent Examples and Personal Perspectives
Authors: Ahmad Nadia M.
Published: July 2016

Review: 41 refs.
ChemInform Abstract: Synthesis of Amino Heterocycle Aspartyl Protease Inhibitors
Authors: Chambers Rachel K. , Khan Tanweer A. , Olsen David B. , Sleebs Brad E.
Published: July 2016

Review: [51 refs.
ChemInform Abstract: 1′‐Homonucleosides and Their Structural Analogues: A Review
Authors: Wroblewski Andrzej E. , Glowacka Iwona E. , Piotrowska Dorota G.
Published: July 2016

Review: 132 refs.
ChemInform Abstract: β‐Peptide Bundles: Design. Build. Analyze. Biosynthesize
Authors: Wang Pam S. P. , Schepartz Alanna
Published: July 2016

Review: 109 refs.
ChemInform Abstract: A High‐Content Screening Platform with Fluorescent Chemical Probes for the Discovery of First‐in‐Class Therapeutics
Authors: Jo Ala , Jung Jinjoo , Kim Eunha , Park Seung Bum
Published: July 2016

Review: 86 refs.
ChemInform Abstract: Recent Developments of C‐4 Substituted Coumarin Derivatives as Anticancer Agents
Authors: Dandriyal Jyoti , Singla Ramit , Kumar Manvendra , Jaitak Vikas
Published: July 2016

Review: 100 refs.
ChemInform Abstract: Regulation of Beta‐Cell Function and Mass by the Dual Leucine Zipper Kinase
Authors: Oetjen Elke
Published: July 2016

Review: 46 refs.
ChemInform Abstract: Colloidal Mesoporous Silica Nanoparticles
Authors: Yamamoto Eisuke , Kuroda Kazuyuki
Published: July 2016

Review: 369 refs.
ChemInform Abstract: Supramolecular Gels Made from Nucleobase, Nucleoside and Nucleotide Analogues
Authors: Peters Gretchen Marie , Davis Jeffery T.
Published: July 2016

Review: 157 refs.
ChemInform Abstract: Modeling and Simulations in Photoelectrochemical Water Oxidation: From Single Level to Multiscale Modeling
Authors: Zhang Xueqing , Bieberle‐Huetter Anja
Published: July 2016

Review: [95 refs.
ChemInform Abstract: Magnetic Mechanisms of Pairing in Strongly Correlated Electron System of Copper Oxides
Authors: Ovchinnikov S. G. , Makarov I. A. , Shneyder E. I. , Togushova Yu. N. , Gavrichkov V. A. , Korshunov M. M.
Published: July 2016

Review: 241 refs.
ChemInform Abstract: Chiral Derivatizing Agents, Macrocycles, Metal Complexes, and Liquid Crystals for Enantiomer Differentiation in NMR Spectroscopy
Authors: Wenzel Thomas J.
Published: July 2016

Review: 248 refs.
Out of the forest: past and present range expansion of a parthenogenetic weevil pest, or how to colonize the world successfully
Authors: Rodriguero Marcela S. , Lanteri Analía A. , Guzmán Noelia V. , Carús Guedes Jerson V. , Confalonieri Viviana A.
Published: July 2016

Previous research revealed complex diversification patterns in the parthenogenetic weevil Naupactus cervinus. To understand the origin of clonal diversity and successful spreading of this weevil, we investigated its geographic origin and possible dispersal routes and whether parthenogens can persist in habitats under unsuitable environmental conditions. This study is based on samples taken throughout a broad area of the species’ range. We used both mitochondrial and nuclear markers and applied phylogenetic and network analyses to infer possible relationships between haplotypes. Bayesian phylogeographic analyses and ecological niche modeling were used to investigate the processes that shaped genetic diversity and enabled the colonization of new geographic areas. Southeastern Brazil emerges as the original distribution area of N. cervinus. We detected two range expansions, one along natural corridors during the Pleistocene and the other in countries outside South America during recent times. Isolation due to climate shifts during the early Pleistocene led to diversification in two divergent clades, which probably survived in different refugia of the Paranaense Forest and the Paraná River delta. The origin of the clonal diversity was probably a complex process including mutational diversification, hybridization, and secondary colonization. The establishment of N. cervinus in areas outside its native range may indicate adaptation to drier and cooler conditions. Parthenogenesis would be advantageous for the colonization of new environments by preventing the breakup of successful gene combinations. As in other insect pests, the present distribution of N. cervinus results from both its evolutionary history and its recent history related to human activities.
Knocking back invasions: variable resistance and resilience to multiple cold spells in native vs. nonnative fishes
Authors: Rehage J. S. , Blanchard J. R. , Boucek R. E. , Lorenz J. J. , Robinson M.
Published: July 2016

Extreme climate events can interact synergistically with invasions to dramatically alter ecosystem structure, function, and services. Yet, the effects of extreme climate events on species invasions remain unresolved. Extreme climate events may increase resources and decrease biotic resistance by causing physiological stress and/or mortality of native taxa, resulting in invasion opportunities for nonnative species. Alternatively, extreme climate events may regulate nonnative populations, preventing them from achieving dominance. We examined whether a sequence of three cold spells had a negative or positive effect on fish invasions in the coastal Everglades. We compared resistance (initial effects) and resilience (rate of recovery) to the cold spells between native fishes and the dominant nonnative invader, the Mayan cichlid, across eight populations expanding two mangroves drainages in the southern Everglades. We tracked native fish and nonnative Mayan cichlid populations for 10 yr including 3 yr pre‐ and 4 yr post‐cold spells. In both drainages, native fishes were more resistant to the cold spells than the nonnative species. While native fishes experienced declines at only one site, nonnative Mayan numbers were reduced by 90–100% across six sites where they were abundant pre‐disturbances. Four years after the last cold spell, we saw limited resilience in the affected nonnative populations. Only one of the six affected sites fully recovered, whereas the other five sites showed no recovery in Mayan cichlid numbers. The recovered site was closest to a canal, known to act as thermal refuges for nonnative fishes. In summary, cold spells can reduce nonnative abundances, but whether cold spells can effectively knock back invasions (and range expansions) by tropical/subtropical nonnative species will depend on how the frequency and severity of cold spells are affected by climate change. We propose that these mortality‐causing extreme events could provide rare management opportunities late in an invasion.
Uncertainty in the net hydrologic flux of calcium in a paired‐watershed harvesting study
Authors: Campbell John L. , Yanai Ruth D. , Green Mark B. , Likens Gene E. , See Craig R. , Bailey Amey S. , Buso Donald C. , Yang Daqing
Published: July 2016

Monitoring solutes in precipitation inputs and stream water exports at small watersheds has greatly advanced our understanding of biogeochemical cycling. Surprisingly, although inputs to and outputs from ecosystems are instrumental to understanding sources and sinks of nutrients and other elements, uncertainty in these fluxes is rarely reported in ecosystem budgets. We illustrate error propagation in input–output budgets by comparing the net hydrologic flux of Ca in a harvested and reference watershed at the Hubbard Brook Experimental Forest, New Hampshire. We identify sources of uncertainty and use a Monte Carlo approach to combine many sources of uncertainty to produce an estimate of overall uncertainty. Sources of uncertainty in precipitation inputs included in this study were: rain gage efficiency (undercatch or overcatch), gaps in measurements of precipitation volume, selection of a model for interpolating among rain gages, unusable precipitation chemistry, and chemical analysis. Sources of uncertainty in stream water outputs were: stage height–discharge relationship, watershed area, gaps in the stream flow record, chemical analysis, and the selection of a method for flux calculation. The annual net hydrologic flux of Ca in the harvested and reference watersheds was calculated from 1973 through 2009. Relative to the reference watershed, the harvested watershed showed a marked increase in Ca flux after it was cut in 1983–1984, and slowly declined toward pretreatment levels thereafter. In 2009, the last year evaluated, the 95% confidence intervals for the annual estimates approach the 95% confidence intervals of the pretreatment regression line, suggesting that the increased net loss of Ca in the harvested watershed may soon be indistinguishable from the reference. Identifying the greatest sources of uncertainty can be used to guide improvements, for example in reducing instances of unusable precipitation chemistry and gaps in stream runoff. Our results highlight the value of estimating uncertainty in watershed studies, including those in which replication is impractical.
Life history traits and spawning behavior modulate ecosystem‐level effects of nutrient subsidies from fish migrations
Authors: Childress Evan S. , McIntyre Peter B.
Published: July 2016

Migratory animals can have profound impacts on ecosystem structure and function. In streams, salmon are well known for their contrasting influences on primary productivity through nutrient delivery, which enhances potential productivity, and substrate disturbance during nest building, which reduces algal biomass and primary production. However, most migratory fish species neither disturb the substrate significantly nor die en masse after spawning, hence their influence on ecosystems may differ from that observed in salmon streams. To determine the influence of nutrient subsidies from migrations of iteroparous fish whose broadcast spawning does not disturb the substrate substantially, we compared nutrient limitation, nutrient concentrations, and stream metabolism during spawning migrations of suckers (Catostomus spp.) in Lake Michigan tributaries with and without migration barriers. Although suckers deliver both nitrogen and phosphorus as eggs and waste excretion, only nitrogen concentrations were elevated during the migration (NH4‐N rose 44% relative to sites without a sucker run). Nutrient diffusing substrates demonstrated P‐limitation during the migration at sites spanning a wide range of sucker abundance, suggesting that high demand for likely masked P inputs from fish. Time series analyses indicated that gross primary production (GPP) increased with sucker excretion, but not with egg deposition after accounting for abiotic conditions. In contrast, egg deposition, but not excretion, was associated with a slight increase in ecosystem respiration (ER), suggesting that sucker gametes provide labile carbon that contributes to ER. The effects of suckers contrast with ecosystem responses to salmon migrations, which elevate ER but have mixed effects on GPP. This disparity reflects the fact that suckers fertilize streams without attendant disturbance effects. Our results suggest that basic differences in life history and behavior of migratory fish determine the direction and magnitude of their ecosystem effects. As a result, broad trait‐based predictions of the ecosystem role of migratory fishes may become possible as more species are studied.
Divergent reproductive allocation trade‐offs with canopy exposure across tree species in temperate forests
Authors: Berdanier Aaron B. , Clark James S.
Published: July 2016

Variation in tree reproduction can alter forest community dynamics, especially if reproductive output is costly for other functions like growth. However, empirical studies reach conflicting conclusions about the constraints on reproductive allocation relative to growth and how they vary through time, across species, and between environments. Here, we test the hypothesis that a critical resource, canopy exposure to light availability, limits reproductive allocation by comparing long‐term relationships between reproduction and growth for trees from 21 species in forests throughout the Southeastern United States. We found that species have divergent responses to light availability, with shade‐intolerant species experiencing an alleviation of trade‐offs at high light‐ and shade‐tolerant species showing no changes in reproductive output across light environments. Correlations between temporal variation in individual growth and reproduction were weak and generally insensitive to canopy exposure, but changed when considering time lags. The diversity of responses across species indicates that reproductive allocation for trees in these forests is strongly influenced by both species’ life history and environmental heterogeneity in space and time.
Metapopulation dynamics guide marine reserve design: importance of connectivity, demographics, and stock enhancement
Authors: Puckett B. J. , Eggleston D. B.
Published: July 2016

The concepts of metapopulation persistence and source‐sink dynamics are central and often untested tenets of marine reserve networks. Effective application of these concepts to marine reserves is limited by data on demographic rates within reserves and larval connectivity among reserves. Using a network of reserves established to restore eastern oyster (Crassostrea virginica) in Pamlico Sound, North Carolina, USA as our model system, we integrated empirically based demographic rates and regional hydrodynamic‐based connectivity estimates within a metapopulation model to (1) evaluate the potential for the reserve network to function as a self‐persistent oyster metapopulation, (2) determine the relative importance of demographics vs. connectivity on reserve source‐sink dynamics, (3) assess the efficacy of stock enhancement in promoting metapopulation persistence, and (4) evaluate whether application of a Few Large or Several Small reserves—a modification of the Single Large or Several Small concept—promoted greater metapopulation retention of larvae within the reserve network (i.e., local larval retention within reserves + larval connectivity among reserves). The reserve network failed to function as a self‐persistent metapopulation, despite exceptional demographic rates within reserves. When considering only larval supply from reserves, local retention and connectivity were insufficient to provide annual replacement (≥~0.25 recruits per adult). Accordingly, reserves contributed to the metapopulation primarily via production, not dispersal, of larvae and reserve source‐sink dynamics were influenced more by demographics within reserves, particularly adult growth and survival, than larval connectivity among reserves. Addressing recruitment limitation via stock enhancement was not effective at augmenting projected metapopulation declines. Several small reserves initially promoted greater metapopulation retention of larvae than a few large reserves, however, as the number or area of reserves increased, metapopulation retention was equivalent among designs, suggesting that Few Large and Several Small reserves may be the best network design. Marine reserves can be an effective restoration tool for improving demographic rates within reserve boundaries, but designation of multiple reserves does not guarantee a functional reserve network metapopulation. Both demographics and larval connectivity are important considerations to successful application of metapopulation concepts to the design of reserve networks.
The relative contribution of climate to changes in lesser prairie‐chicken abundance
Authors: Ross Beth E. , Haukos David , Hagen Christian , Pitman James
Published: July 2016

Managing for species using current weather patterns fails to incorporate the uncertainty associated with future climatic conditions; without incorporating potential changes in climate into conservation strategies, management and conservation efforts may fall short or waste valuable resources. Understanding the effects of climate change on species in the Great Plains of North America is especially important, as this region is projected to experience an increased magnitude of climate change. Of particular ecological and conservation interest is the lesser prairie‐chicken (Tympanuchus pallidicinctus), which was listed as “threatened” under the U.S. Endangered Species Act in May 2014. We used Bayesian hierarchical models to quantify the effects of extreme climatic events (extreme values of the Palmer Drought Severity Index [PDSI]) relative to intermediate (changes in El Niño Southern Oscillation) and long‐term climate variability (changes in the Pacific Decadal Oscillation) on trends in lesser prairie‐chicken abundance from 1981 to 2014. Our results indicate that lesser prairie‐chicken abundance on leks responded to environmental conditions of the year previous by positively responding to wet springs (high PDSI) and negatively to years with hot, dry summers (low PDSI), but had little response to variation in the El Niño Southern Oscillation and the Pacific Decadal Oscillation. Additionally, greater variation in abundance on leks was explained by variation in site relative to broad‐scale climatic indices. Consequently, lesser prairie‐chicken abundance on leks in Kansas is more strongly influenced by extreme drought events during summer than other climatic conditions, which may have negative consequences for the population as drought conditions intensify throughout the Great Plains.
Dynamic Simulation of Fixed‐Bed Chemical‐Looping Combustion Reactors Integrated in Combined Cycle Power Plants
Authors: Chen Chen , Han Lu , Bollas George M.
Published: July 2016

Chemical‐looping combustion (CLC) is a promising and efficient method for power generation with in situ CO2 capture. In this work, we focus on high‐pressure fixed‐bed CLC reactors integrated with combined cycle (CC) power plants. Specifically, the dynamic nature of fixed‐bed chemical‐looping reactors and the many kinetically controlled reactions necessitate the use of dynamic modeling to evaluate power plant performance, efficiency, stability, and feasibility under transient operation. We present a dynamic model for an integrated CLC–CC power plant and transient analyses of the integrated plant performance. A network of dynamically operated fixed‐bed reactors fed with natural gas comprises the CLC plant component. A dynamic model is developed and tuned to match the performance of a commercial combined cycle power plant. The transient variations of the integrated plant in terms of power, temperature, and pressure profiles are presented. The simulation results show that despite the inherent batch‐type operation of the CLC reactor, the operation of the combined cycle is relatively unaffected, and there are small oscillations of approximately 2 % around the desired steady‐state conditions.
On the Experimental Evidence of Exothermicity in Wood and Biomass Pyrolysis
Authors: Di Blasi Colomba , Branca Carmen , Galgano Antonio
Published: July 2016

Reaction‐induced overheating during the pyrolysis of lignocellulosic material has been reported by various authors, but it is still one of the less understood aspects of the process. This Review outlines the experimental results for a mixed kinetic‐transport control in which exothermicity is displayed clearly. The thermal conditions and the feedstock properties that enhance these events are discussed. Intraparticle activity, at the microscopic level, of homogeneous and heterogeneous reactions of vapor‐phase tars is the main cause of the strong exothermicity, which is more significant for hardly porous materials. Pyrolytic (thermal) runaway is also sometimes observed for fixed‐bed pyrolyzers. This is initiated by the fast release rate of tarry vapors at low temperatures (in the presence of catalytically active ash and significant contents of extractives and hemicelluloses) over wide spatial extensions. Then, the acceleration of the sample heating rate triggers the degradation of the other chemical components.
Performance of Perovskite‐Type Oxides as Oxygen‐Carrier Materials for Chemical Looping Combustion in the Presence of H2S
Authors: Pishahang Mehdi , Larring Yngve , Sunding Martin , Jacobs Marijke , Snijkers Frans
Published: July 2016

In this study, the redox behavior and the effect of the presence of sulfur on the performance of the CaTixMn0.9−xMg0.1O3 perovskite‐type system were investigated. A detailed thermodynamic and thermogravimetric approach combined with post‐characterization was utilized. Ti doping positively influenced the reduction reaction rate and broadened the operation window of the oxygen carrier material (OCM) to lower temperatures. Although sulfur accumulation during the chemical looping with oxygen uncoupling conditions was thermodynamically inevitable owing to sulfate formation, deep redox cycles were shown to remove the accumulated sulfur from the OCM after the sour cycles. Post‐characterization by scanning electron microscopy and sulfur mapping confirmed the effectiveness of this treatment.
Analysis of Catalyst Layer Microstructures: From Imaging to Performance
Authors: Sabharwal M. , Pant L. M. , Putz A. , Susac D. , Jankovic J. , Secanell M.
Published: July 2016

Image analysis and numerical simulation algorithms are introduced to analyze the micro‐structure, transport, and electrochemical performance of thin, low platinum loading inkjet printed electrodes. A local thresholding algorithm is used to extract the catalyst layer pore morphology from focused ion beam scanning electron microscopy (FIB‐SEM) images. n‐point correlation functions, such as auto‐correlation, chord length, and pore‐size distribution are computed to interpret the micro‐structure variations between different images of the same catalyst layer. Pore size distributions are in agreement with experimental results. The catalyst layer exhibits anisotropy in the through‐plane direction, and artificial anisotropy in the FIB direction due to low slicing resolution. Microscale numerical mass transport simulations show that transport predictions are affected by image resolution and that a minimum domain size of 200 nm is needed to estimate transport properties. A micro‐scale electrochemical model that includes a description of the ionomer film resistance and a multi‐step electrochemical reaction model for the oxygen reduction reaction is also presented. Results show that the interfacial mass transport resistance in the ionomer film has the largest effect on the electrochemical performance.
OTX015 (MK‐8628), a novel BET inhibitor, displays in vitro and in vivo antitumor effects alone and in combination with conventional therapies in glioblastoma models
Authors: Berenguer‐Daizé Caroline , Astorgues‐Xerri Lucile , Odore Elodie , Cayol Mylène , Cvitkovic Esteban , Noel Kay , Bekradda Mohamed , MacKenzie Sarah , Rezai Keyvan , Lokiec François , Riveiro Maria E. , Ouafik L'Houcine
Published: July 2016

Bromodomain and extraterminal (BET) bromodomain (BRD) proteins are epigenetic readers that bind to acetylated lysine residues on chromatin, acting as co‐activators or co‐repressors of gene expression. BRD2 and BRD4, members of the BET family, are significantly increased in glioblastoma multiforme (GBM), the most common primary adult brain cancer. OTX015 (MK‐8628), a novel BRD2/3/4 inhibitor, is under evaluation in dose‐finding studies in solid tumors, including GBM. We investigated the pharmacologic characteristics of OTX015 as a single agent and combined with targeted therapy or conventional chemotherapies in glioblastoma cell lines. OTX015 displayed higher antiproliferative effects compared to its analog JQ1, with GI50 values of approximately 0.2 µM. In addition, C‐MYC and CDKN1A mRNA levels increased transiently after 4 h‐exposure to OTX015, while BRD2, SESN3, HEXIM‐1, HIST2H2BE, and HIST1H2BK were rapidly upregulated and sustained after 24 h. Studies in three additional GBM cell lines supported the antiproliferative effects of OTX015. In U87MG cells, OTX015 showed synergistic to additive activity when administered concomitant to or before SN38, temozolomide or everolimus. Single agent oral OTX015 significantly increased survival in mice bearing orthotopic or heterotopic U87MG xenografts. OTX015 combined simultaneously with temozolomide improved mice survival over either single agent. The passage of OTX015 across the blood–brain barrier was demonstrated with OTX015 tumor levels 7 to 15‐fold higher than in normal tissues, along with preferential binding of OTX015 to tumor tissue. The significant antitumor effects seen with OTX015 in GBM xenograft models highlight its therapeutic potential in GBM patients, alone or combined with conventional chemotherapies.