bluuebunny/crossref_metadata_2025 huggingface dataset:
Projekte hocheffektiv umsetzen
Authors: Achenbach Timo
Published: September 2023

Die Umsetzung von Veränderungsvorhaben gelangt früher oder später an einen kritischen Punkt: wenn zu viele Aktivitäten – meist aus Aktionismus – auf einmal gestartet werden. Es entsteht ein Dickicht an Aufgaben, an deren Erledigung man unter allen Umständen festhält. Keiner hinterfragt mehr, ob diese Aufgaben überhaupt auf die Zielerreichung einzahlen, oder ob es nicht einen besseren, sprich schnelleren Weg gibt. Die Lösung: Ergebnisorientierung! Ergebnis- anstatt Aktivitätenfokus ist eines der wichtigsten Prinzipien für hocheffektives Umsetzungsmanagement.
Initiative en santé buccodentaire des enfants : le point de vue des intervenants quant à ses effets dans les communautés des Premières Nations
Authors: Schroth Robert J. , Kyoon-Achan Grace , McNally Mary , Edwards Jeanette , White Penny , Tait Neufeld Hannah , Bertone Mary , Hayes Alyssa , Hai-Santiago Khalida , Star Leona , McNab Fontaine Wendy , Yerex Kathy , Olatosi Olubukola O. , Moffatt Michael E. K. , Cruz de Jesus Vivianne
Published: September 2023

Introduction

Depuis 2004, l’équipe de l’Initiative en santé buccodentaire des enfants (ISBE) oeuvre dans de nombreuses communautés inuites et des Premières Nations du Canada à remédier aux disparités en matière de santé buccodentaire, en particulier en ce qui concerne la carie de la petite enfance. Alliant prévention et dentisterie peu invasive, l’approche communautaire de l’ISBE améliore la santé buccodentaire dans la petite enfance. Le programme a pour but de réduire le plus possible le fardeau de la maladie buccodentaire, en particulier d’éviter les opérations chirurgicales. Nous avons étudié les résultats du programme au sein des communautés des Premières Nations du Manitoba du point de vue du personnel de l’ISBE.

Méthodologie

Des thérapeutes dentaires et des aides dentaires oeuvrant dans des communautés des Premières Nations ont participé à trois groupes de discussion et à une entrevue semi-structurée approfondie. Les données rassemblées ont été analysées par thème.

Résultats

Des thèmes convergents propres aux professionnels des soins dentaires sont ressortis des données obtenues auprès de 22 participants. Les participants ont indiqué que les thérapeutes dentaires et les aides dentaires offrent un accès à des soins buccodentaires de base dans les communautés : l’évaluation de la santé buccodentaire, le nettoyage des dents, l’application de vernis fluoré et la pose d’agents de scellement. Les participants étaient d’accord pour affirmer que l’éducation, l’information et des relations culturellement appropriées avec les parents sont cruciales pour la prestation d’un soutien continu et le renforcement des capacités au sein des programmes communautaires. Parmi les défis mentionnés, il y a le peu d’inscriptions au programme, les difficultés d’accès aux domiciles et d’obtention du consentement, le manque de ressources humaines et l’insuffisance des occasions d’apprentissage offertes aux aides dentaires.

Conclusion

Dans l’ensemble, les participants ont indiqué que l’ISBE contribuait favorablement à la santé buccodentaire dans la petite enfance au sein des communautés des Premières Nations. Cependant, une offre accrue en matière de formation du personnel dentaire au sein des communautés, le fait que les membres des communautés soient au courant de l’existence du programme et la participation des parents en vue de processus de prestation et de consentement culturellement appropriés seraient essentiels à l’amélioration des résultats du programme.
An interrupted time series evaluation of the effect of cannabis legalization on intentional self-harm in two Canadian provinces: Ontario and Alberta
Authors: Cusimano Michael D. , Carpino Melissa , Walker Madison , Saarela Olli , Mann Robert
Published: September 2023

Introduction

Despite the association between cannabis use and higher prevalence of suicidal ideation and attempt, the effect of cannabis legalization and regulation in Canada on intentional self-harm has not been determined.

Methods

We used an interrupted time series of population-based rates of emergency department (ED) visits and hospitalizations for intentional self-harm per 100 000 in Ontario and Alberta from January/April 2010 to February 2020. Aggregate monthly counts of ED visits and hospitalizations for intentional self-harm (ICD-10 codes X60–X84, R45.8) were obtained from the National Ambulatory Care Reporting System and Discharge Abstract Database, respectively.

Results

The legalization and regulation of cannabis in Canada was not significantly associated with a change in rates of ED visits for intentional self-harm in Ontario (level = 0.58, 95% CI: −1.14 to 2.31; trend = −0.17, 95% CI: −0.35 to 0.01) or Alberta (level = −0.06, 95% CI: −2.25 to 2.12; trend = −0.07, 95% CI: −0.27 to 0.13). Hospitalizations for intentional self-harm also remained unchanged in Ontario (level = −0.14, 95% CI: −0.48 to 0.20; trend = 0.01, 95% CI: −0.03 to 0.04) and Alberta (level = −0.41, 95% CI: −1.03 to 0.21; trend = −0.03, 95% CI: −0.08 to 0.03).

Conclusion

Legalization and regulation of cannabis in Canada has not increased rates of ED visits or hospitalizations for intentional self-harm in Ontario and Alberta. Individual-level analyses that account for demographic characteristics and include other provinces and territories are needed.
Validating existing clinical cut-points for the parent-reported Strengths and Difficulties Questionnaire in a large sample of Canadian children and youth
Authors: Turner Sarah E. , Dopko Raelyne L. , Goldfield Gary , Cloutier Paula , Pajer Kathleen , Abdessemed Mohcene , Mougharbel Fatima , Ranney Michael , Hoffmann Matt D. , Lang Justin J.
Published: September 2023

Introduction

The Strengths and Difficulties Questionnaire (SDQ), for assessing behavioural and emotional difficulties, has been used internationally as a screening measure for mental health problems. Our objective was to validate the existing (British) SDQ cut-points in a sample of Canadian children and youth, and develop new Canadian SDQ cut-points if needed.

Methods

This study includes data from children and youth aged 6 to 17 years from the Canadian Health Measures Survey (n = 3435) and outpatient records from the Children’s Hospital of Eastern Ontario (n = 1075). The parent-reported SDQ data were collected. We adjusted the existing SDQ cut-points using a distributional and receiver-operating characteristic (ROC) curve approach. We subsequently calculated the sensitivity, specificity and diagnostic odds ratio of the existing and new SDQ clinical cut-points to determine whether the new cut-points had better clinical utility, using both analytic approaches.

Results

Our data show differences in the screening effectiveness between the existing British and the Canadian-specific clinical cut-points. Specificity is maximized using the Canadian distributional cut-points, improving the likelihood of identifying true negative results. The total SDQ score met the threshold for clinical utility (diagnostic odds ratio > 20) using both the existing and new cut-points; however, the individual scales did not reach clinical utility threshold using either cut-points.

Conclusion

Future Canadian SDQ research should consider the new cut-points derived from our study population and the existing British cut-points to allow for historical and international comparisons.
Transcending the Bounds of Temporality and Spatiality: Mythical Retelling of Femininity in Carol Ann Duffy’s The World’s Wife
Authors: Mathew Dr. Nisha
Published: September 2023

Poetry, despite the side-liningfaced due to the profusion of the novel, has made a comeback marking its genuine presence with its ability to combine the imaginative and the creative to project the real. Contemporary poetry, pluralistic, experimental and diverse in form encompassing the nature culture and history of the world has been drawing intense thematic and theoretical attention to itself. Myths play an important role in literature especially in expressing modernist tendencies as done by the twentieth century poet T S Eliot. Similarly, the former Poet Laureate of Britain, Carol Ann Duffy, has subverted myths to bridge the gap between the traumatic experiences of mythical women and the contemporary ones. The paper Transcending the Bounds of Temporality and Spatiality: Mythical Retelling of Femininity in Carol Ann Duffy’s The World’s Wife intends to portray how Carol Ann Duffy projects the problems of women through parading female characters from history, mythology and fairy tales. The technique of mythical subversion has helped her to dismantle the popular notions associated with women (self-sacrificing and self-effacing). The paper thus examines in detail, using the elements of myth criticism, the poems in The World’s Wife to find out the different facets of women presented by Duffy using mythical subversion.
BAHASA DALAM KELUARGA MELAYU DI BANSIR DARAT, PONTIANAK
Authors: Nanda Violetta Oktafia
Published: September 2023

In Indonesia there are several ethnic groups and national cultures. Management must be aware of the unique culture of each ethnic group in order to apply it more effectively and skillfully in the home environment. Malay culture and ethnicity, which is the largest ethnic group in Indonesia, is the focus of this study. The national cultural component is used to differentiate cultural variants among diverse ethnic groups. To form an effective family, communication is interaction that occurs in groups, especially in family interactions where a child is expected to understand and follow the directions of his parents. Similarly, parents must provide a good education to their children. In order to obtain data sources for this study, a family residing in Indonesia—specifically, West Kalimantan in Pontianak City—was interviewed and observed. This interview was conducted using particular questions on language and ethnicity. It is obvious that the responses to the questions will depend on how well the study subjects—namely, the two family members—understand them. Second, there is mutual understanding among Malay family members, wherein family members may mold personalities. These two factors together help produce a tranquil home atmosphere where children can be more readily overseen by parents in their growth. Third, communication between family members using Malay is done for harmony, with parents recognizing the problems and sentiments of children as well as parents' hectic schedules.
Sobre afetos e afetividades
Authors: Medeiros Vera Lúcia Cardoso , Fernandes Frederico Garcia
Published: September 2023

Apresentação dossiê: A literatura e seus afetos
A leitura como afeto
Authors: Bicicgo Cleber
Published: September 2023

Na obra O avesso da pele (2020), romance escrito por Jeferson Tenório, os afetos assumem o papel central ao tratar do racismo. Nas tramas desses afetos, o encontro entre texto e leitor permite mergulhar num espaço onde a pele não possui cor. Desse lugar baseado no conhecimento imaginativo da ficção, buscamos refletir como as cenas de leitura apresentadas na obra produzem afetos a partir do encontro entre texto e leitor, para compreender como esses afetos parecem emergir dessa relação. O resultado aponta para um modo de ler no qual o afetar-se com o afeto do outro, através da leitura literária, abre a possibilidade de ampliar as experiências humanas.
Epistemologia dos afetos a partir dos arquivos histórico-memorialísticos em Relato de um certo Oriente
Authors: Prevedello Tatiana
Published: September 2023

O pensamento de Paul Ricoeur, em A memória, a história, o esquecimento, investe na elaboração epistemológica do discurso histórico, por intermédio dos elementos memorialísticos que instrumentalizam a representação narrativa. Na fase nomeada como “documental”, o “espaço habitado”, o “tempo histórico”, o “testemunho”, o “arquivo” e a “prova documental” configuram a “memória arquivada” (Ricoeur, 2007, p. 155). Nessa perspectiva, o objetivo deste estudo é analisar a relação entre os arquivos da memória e os dispositivos que operacionalizam a inscrição do discurso histórico na narrativa, os quais são instrumentos preponderantes para se compreender a hermenêutica dos afetos em Relato de um certo Oriente, primeiro romance do escritor amazonense de ascendência árabe, Milton Hatoum, publicado em 1989. O texto realiza uma incursão mnemônica pelos escombros do passado de uma família de origem libanesa, a qual habita Manaus, nas primeiras décadas do século XX, como sinalizam os marcos temporais indicados pelas vozes narrativas
Poly(ADP-ribose) Polymerase Inhibitor Olaparib in the Treatment of Ovarian Cancer: A Comprehensive Review of Current Literature
Authors: Poboży Kamil , - - , - -
Published: September 2023

Purpose of the review: This comprehensive review aims to provide a summary of current research on the utilization of olaparib, a poly(ADP-ribose) polymerase (PARP) inhibitor, in the treatment of ovarian cancer. The review aims to highlight the key findings from recent clinical trials and assess the potential of olaparib as a targeted therapy for improving the prognosis of ovarian cancer patients.

Recent findings: Ovarian cancer remains a significant global health concern with high mortality rates. While optimal debulking surgery and platinum-based chemotherapy are the standard treatments, the recurrence rates remain substantial. The emergence of PARP inhibitors, particularly olaparib, has introduced a novel therapeutic approach that targets the genomic instability and DNA repair mechanisms in cancer cells. Notable clinical trials, such as SOLO1, SOLO2, and PAOLA-1, have demonstrated the effectiveness of olaparib in significantly improving progression-free survival, particularly in patients with BRCA mutations or homologous recombination deficiency. Additionally, combination therapies involving olaparib, such as those with bevacizumab or entinostat, have shown promising results.

Summary: The utilization of olaparib has brought about a paradigm shift in the treatment of ovarian cancer. Notably, it has shown significant improvements in progression-free survival and overall survival, particularly in patients with BRCA mutations or homologous recombination deficiency. The exploration of olaparib through various clinical trials and combination therapies continues to provide valuable insights and offer new prospects for ovarian cancer patients. Moreover, the growing understanding of PARP inhibitors holds the potential for further advancements in the prognosis of patients with this formidable condition.
Enhancing building maintainability through early supplier involvement in the design process
Authors: Othman Ayman Ahmed Ezzat , Kamal Ahmed
Published: September 2023

The post-construction phase represents a critical milestone in the project lifecycle. This is because design errors and omissions as well as construction defects are examined during this phase. The traditional procurement approaches that are commonly adopted in construction projects separate design from construction, which inhibits contractors, suppliers and other parties from providing the design team with constructive comments and feedback to improve the project design. Consequently, lack of considering maintainability aspects during the design process results in increasing maintenance and operation costs as well as reducing building performance. This research aims to investigate the role of early supplier involvement (ESI) in the design process as an approach for enhancing building maintainability. To achieve this aim, a research methodology consisted of literature review, case studies and survey questionnaire was designed to accomplish four objectives. Firstly, literature review was used to examine the concepts of building maintenance, maintainability, the design process and ESI. Secondly, three case studies were presented and analysed to investigate the role of ESI towards enhancing building maintainability during the design process. Thirdly, a survey questionnaire was conducted with a representative sample of architectural design firms (ADFs) in Egypt to investigate their perception and application of ESI towards enhancing building maintainability during the design process. Finally, the research developed a framework to facilitate ESI during the design process in ADFs in Egypt. Data analysis showed that ‘Difficulty of trusting external parties and sharing information with transparency’ was ranked the highest challenge of ESI in ADFs in Egypt.
Efektivitas Pemberian Kombinasi Teh Daun Mint (Mentha piperita) dan Madu terhadap Intensitas Nyeri Haid (Dismenore)
Authors: Anfusufi Nafara Aghnia , Ramadhan Adam M. , Siregar Vita Olivia
Published: September 2023

Dismenore atau nyeri haid masih menjadi masalah utama pada kebanyakan wanita. Banyak cara yang dapat dilakukan untuk mengatasi nyeri dismenore, salah satunya dengan mengkonsumsi minuman herbal. Daun mint mengandung senyawa menthol yang dapat mengurangi kontraksi pada miometrium sehingga nyeri dismenore yang dirasakan dapat berkurang. Flavonoid yang terkandung dalam madu mampu mengurangi rasa nyeri dengan menghambat pembentukan prostaglandin melalui penghambatan enzim cyclooxygenase. Sehingga kombinasi keduanya dapat bekerja secara sinergis dalam menurunkan intensitas nyeri dismenore. Penelitian ini bertujuan untuk mengetahui efektivitas pemberian teh daun mint (Mentha piperita) dan madu terhadap penurunan intensitas nyeri haid (dismenore). Metode penelitian yang digunakan adalah quasy experimental dengan pengambilan sampel secara purposive sampling dan didapatkan 50 responden yang terbagi menjadi 2 kelompok. Hasil yang didapat pada kedua kelompok responden dismenore setelah pemberian kombinasi teh daun mint dan madu selama 2 hari yaitu terjadi penurunan antara pretest dan posttest dengan nilai sinifikansi 0,000 (p<0,05) yang berarti terdapat perbedaan yang signifikan antara pretest dan posttest. Sedangkan untuk perbandingan penurunan skala nyeri antara kedua kelompok yaitu kelompok uji dan kelompok kontrol didapatkan nilai signifikansi 0,000 (p<0,05) dimana terdapat perbedaan yang signifikan antara kedua kelompok. Berdasarkan hasil penelitian, dapat disimpulkan bahwa kombinasi teh daun mint dan madu efektif dalam menurunkan intensitas nyeri haid (dismenore).
Analisis Proksimat Cookies dari Tepung Sukun (Artocarpus altilis) dan Tepung Buah Naga Merah (Hylocereus polyrhizus)
Authors: Wulandari Putri Diah , Kawareng Andi Tenri , Ahmad Islamudin
Published: September 2023

Prevalensi diabetes mellitus di Indonesia mengalami peningkatan dari tahun ke tahun, sehingga perlu dilakukan upaya pengendalian diabetes mellitus. Salah satu upaya yang dapat dilakukan yaitu dengan pengaturan makan dengan cara diet tinggi serat. Buah sukun dan buah naga merah merupakan pangan dengan kandungan serat yang tinggi. Cookies berbahan dasar tepung sukun dan tepung buah naga merah berpotensi untuk dijadikan makanan selingan bagi penderita diabetes mellitus. Penelitian ini bertujuan untuk mengetahui kandungan gizi pada cookies berbahan dasar tepung sukun dan tepung buah naga merah. Hasil dari pengujian yang dilakukan, diperoleh kadar air 4,51%, kadar abu total 5%, kadar abu tidak larut asam 0,34%, kadar glukosa 1,52%, kadar lemak 22,65%, kadar protein 11,65%, kadar karbohidrat 56,19%, dan kadar serat 21,5%. Cookies berbahan dasar tepung sukun dan buah naga merah memiliki kandungan serat yang tinggi sehingga dapat dijadikan alternatif makanan selingan bagi penderita diabetes mellitus.
Penentuan Konsentrasi Terbaik Hidrogel Tongkol Jagung (Zea Mays L.) dengan Karbopol 940 Menjadi Penurun Panas
Authors: Sirait Ummu Safura , Dalimunthe Gabena Indrayani , Lubis Minda Sari , Yuniarti Rafita
Published: September 2023

Jagung disebut salah satu komoditas unggulan daerah Jamin Ginting, Medan Tuntungan, Sumatera Utara. Penelitian ini untuk mengetahui apakah hemiselulosa dapat digunakan sebagai bahan dasar hidrogel dan untuk mendapatkan konsentrasi formulasi hidrogel terbaik dari kombinasi hemiselulosa pada tongkol jagung (Zea mays L.) dengan karbopol 940 sebagai sediaan obat penurun panas. Isolasi hemiselulosa tongkol jagung dilanjutkan dengan karakterisasi hemiselulosa  meliputi uji organoleptik, uji kelarutan, dan uji FTIR (Fourier Transform Infrared). Sediaan hidrogel pereduksi panas yang diperoleh selanjutnya diuji evaluasi sediaan seperti uji orgnoleptik, homogenitas, pH, keseragaman bobot dan uji derajat perkembangan. Untuk formula sediaan hidrogel yang baik adalah formula 4. Pada uji evaluasi sediaan hidrogel pereduksi panas untuk hasil uji homogenitas semua formula homogen, Hasil uji pH, formula F1 hingga F5 memenuhi syarat rentang pH fisiologis kulit, yaitu 4,5-6,5. Kesimpulan: Hemiselulosa tongkol jagung dapat digunakan sebagai basa atau kombinasi basa gel, dan konsentrasi terbaik terdapat pada formulasi 4, sehingga basis gel hemiselulosa tongkol jagung cocok sebagai hidrogel.
Aktivitas Imunomodulator Ekstrak Etanol Daun Kedondong (Spondias Pinnata) (L.F) Kurz) terhadap Proliferasi Sel Limfosit Mencit Balb/C beserta Uji Kandungan Flavonoid
Authors: Mu’min Muhammad Saiful , Ulfah Maria
Published: September 2023

Paparan benda asing yang bersifat patogen secara terus menerus dapat menurunkan sistem imun, sehingga tubuh membutuhkan senyawa imunomodulator yang mengandung flavonoid. Flavonoid dapat meningkatkan proliferasi sel limfosit.  Penelitian ini bertujuan untuk mengetahui aktivitas imunmodulator ekstrak etanol daun kedondong terhadap proliferasi sel limfosit mencit galur balb/c yang diinduksi vaksin hepaitis B beserta uji kandungan flavonoid. Ekstrak daun kedondong diekstraksi secara maserasi dengan etanol 96%. Ekstrak diberikan secara p.o pada kelompok perlakuan dosis 5, 10 dan 20% kontrol positif levamisol l0,45 mg/20gram BB, kontrol dengan vaksin CMC-Na 0,5% dan kontrol normal selama 46 hari. Sel limfosit diisolasi dari limpa dan diuji proliferasi sel limfosit menggunakan MTT Assay. Identifikasi senyawa flavonoid ekstrak dengan pereaksi Mg dan HCL. Hasil Optical Density (OD) dianalisis statistik Kruskall-Wallis Test dilanjutkan Mann-Whitney taraf kepercayaan 95%. Sedangkan identifikasi kandungan kimia dibandingkan dengan pustaka acuan. Hasil analisis menunjukkan bahwa ekstrak etanol daun kedondong memiliki aktivitas terhadap peningkatan proliferasi sel limfosit pada konsentrasi 10% dan mengandung senyawa flavonoid. Ekstrak etanol daun kedondong memiliki aktivitas imunomodulator dan mengandung senyawa flavonoid.
Total Bakteri Asam Laktat (BAL) dari Sauerkraut Kubis Singgalang (Brassica oleracea var. capitata L.) dengan Konsentrasi Garam yang Berbeda
Authors: Putri Niken Maharani , Fevria Resti , Advinda Linda , Chatri Moralita
Published: September 2023

Bakteri Asam Laktat merupakan kelompok bakteri penghasil asam laktat sebagai produk utamanya dalam proses fermentasi dan merupakan agen probiotik yang baik dan aman bagi manusia. BAL banyak ditemukan pada produk makanan olahan fermentasi salah satunya pada sauerkraut. Sauerkraut  merupakan produk fermentasi yang hanya menggunakan kol dan garam dalam proses pembuatannya. Sauerkraut dapat dibuat dari berbagai jenis sayuran sebangsa kol seperti contohnya Kubis Singgalang (Brassica oleracea var. capitata L.). Kol dapat difermentasi menjadi sauerkraut menggunakan garam dengan konsentrasi tertentu. Penelitan dilakukan dengan 3 kelompok perlakuan yaitu Sauerkraut Kubis Singgalang dengan pemberian konsentrasi garam 2%, 2,5%, dan 3%. Hasil penelitian didapatkan bahwa total BAL terbanyak terdapat pada penambahan garam 2,5% yaitu 186,67×106 cfu/ml. Sedangkan total BAL pada konsentrasi 2% yaitu 83,33×106 cfu/ml dan konsentrasi 3% yaitu 51×106 cfu/ml. Jumlah tersebut sudah memenuhi standar minimum BAL dalam tiap produk dan memenuhi standar minimum agar bermanfaat bagi tubuh manusia.
Escuela de vida Sumak Kawsay. Una experiencia pedagógica orientada al buen vivir
Authors: Murcia Castañeda Lina María , Zabala Archila Mitchel , Dussán Gonzales Olimpo
Published: September 2023

Esta investigación da cuenta de un recorrido que se despliega en la creación de un Aula Pedagógica. Respuesta a la pregunta <<¿Cómo se ha materializado en el Vivero el Cortijo la escuela de vida Sumak Kawsay, donde se resignifica la vida desde el respeto del orden natural y el cuidado del agua?>>, formulada tras la definición del Problema: la paradoja que vive el mundo contemporáneo, el desarrollo desmesurado del capitalismo que pone en cuestión la vida humana en la Tierra, que -según todas las predicciones- está <>.

En el transcurso de la experiencia pedagógica se aparea la historia de vida de Lina María Murcia Castañeda con la conformación de la Escuela Sumak Kawsay. La metodología de la Investigación Creativa Territorial² a través de sus cinco momentos devela los insumos que nutren la naciente experiencia pedagógica.

Los resultados de la investigación definen los aportes realizados por el aula pedagógica, que manifiestan la urgencia en su comprobación e integración. Desde las herramientas de la investigación experiencial se presentan las evidencias materiales e inmateriales de las andaduras de la Escuela de Vida.

Acerca de las conclusiones, vale aclarar que la metodología de la investigación objetiva se limita a un paso a paso operativo, mientras que la metodología concebida desde la investigación creativa nos enfrenta a lo desconocido en el abordaje del presente continuo de la andadura experiencial.
Estudio sobre las prácticas pedagógicas en la primera infancia en una institución educativa pública
Authors: Castro Javela Claudia Patricia
Published: September 2023

La educación inicial tiene como propósito potenciar el desarrollo integral de niños, y niñas, brindar espacios de socialización de calidad y contribuir a una formación que permita adquirir, construir y compartir saberes con sus pares a través de procesos de enseñanza-aprendizaje y experiencias significativas; es por ello que todos los lineamientos curriculares y normativas deben ser analizadas y apropiadas por los diferentes agentes educativos, de tal forma que se impacte positivamente la vida de los niños, a partir de unos saberes disciplinares y pedagógicos donde se reconozca la naturaleza del aprendizaje y de los procesos sociales y culturales en la primera infancia.

En este contexto, la investigación tuvo como objetivo caracterizar las prácticas pedagógicas desarrolladas en el grado transición de una institución educativa pública de la ciudad de Neiva, en la cual se analizó, además, la coherencia entre las prácticas pedagógicas empleadas y las bases curriculares para la educación inicial y preescolar planteadas por el MEN.

La naturaleza metodológica de la investigación fue de enfoque cualitativo con método etnográfico y se emplearon técnicas para la recolección de datos como entrevistas, observación y grupo focal. A partir de los hallazgos del trabajo de campo con las diferentes audiencias (estudiantes, docentes, padres de familia y directivos), se hizo el análisis de la información, se establecieron conclusiones y recomendaciones que permitieron analizar y consolidar la naturaleza de las prácticas pedagógicas empleadas por las docentes en el grado transición de la institución objeto de estudio.
Coherencia entre los discursos, los compromisos de los sujetos sociales y los procesos pedagógicos básicos relacionados con la investigación en la educación básica secundaria y media
Authors: Cruz Hernández Cristian Arbey , García Cedeño Xiomara Natalia
Published: September 2023

El presente artículo científico valora la coherencia entre los discursos, los compromisos de los sujetos sociales y los procesos pedagógicos básicos que se relacionan con la investigación en la educación secundaria y media. La investigación indaga la existencia o no existencia de una coherencia entre las tres categorías señaladas discursos, procesos pedagógicos básicos y la responsabilidad de los sujetos sociales (docentes y directivos docentes); teniendo en cuenta que constantemente se plantea dentro de las políticas públicas y las acciones del sistema educativo construir investigación, un discurso que se mantiene y asume un papel preponderante en la sociedad; sin embargo, en la práctica educativa es necesario reconocer la coherencia. La investigación responde a reconocer las voces de los sujetos sociales, las interpretaciones que tienen los docentes sobre el poder de aquel discurso y cómo se articula en los procesos pedagógicos, la respuesta a las condiciones que hay para realizar investigación, entre otros. La Institución Educativa Técnico Superior de Neiva hace parte de la voz del trabajo investigativo: dieciséis docentes, dos directivos docentes y los documentos de la institución. Metodológicamente es de naturaleza cualitativa, con un enfoque investigativo de estudio etnográfico. Los instrumentos implementados para obtener los resultados esperados son la agenda de opinión, observación In situ, foros y narrativas e historias de vida. A partir de los hallazgos, la información se codificó en el software Atlas ti, esbozando unas redes semánticas que permiten, desde allí, construir una propuesta de intervención para fortalecer los procesos académicos y mejorar la calidad educativa.
Relatos colectivos en la comunidad como factor de protección para la niñez ante pandemia por Covid-19
Authors: Flores Trevizo Paulina , Flores Flores Jorge Alan
Published: September 2023

Se plantea un análisis para desmitificar el supuesto bajo impacto que la pandemia por COVID-19 ha representado para la población infantil. A través de una descripción cronológica de los momentos que atravesó esta población se logra visibilizar la privación de derechos que se perpetró en contra de los niños a raíz de la pandemia. Durante el primer momento se les invisibilizó, asegurando que el virus no los afectaba; el segundo momento los estigmatizó, aseverando que eran súper contagiadores; y el tercer momento, cuando se manifiesta la crisis emocional y física de este grupo poblacional, debido a los impactos que la pandemia les detonó.

Es importante reconocer a este grupo poblacional y asumir que la pandemia también les impactó de manera contundente. Proponemos la herramienta de los relatos colectivos como factor de protección para la niñez ante la pandemia por COVID-19.
On Some Differential Operators Related to A Type of Meromorphic Univalent Functions
Authors: Abdullah Majida Kh. , Juma Abdul Rahman S.
Published: September 2023

The goal of this article is to introduce a class of a type of meromorphic function which defined by some differential operators. Then we study various properties of these operators such as, coefficient inequality, both of growth and distortion theorems, radii of Star likeness and convexity of f(z) in the class that we present it.
First report of a Dengue outbreak in Balsas, Amazonas, Peru, during 2021 and 2022.
Authors: Ramírez-Orrego Lourdes , Rojas Luis M. , Campos Christian J. , Gutierrez Carmen , Chenet Stella M. , Gonzales Lizandro
Published: September 2023

Introduction: The increase in dengue cases in Amazonas is a risk to public health. In 2021, Balsas reported a dengue outbreak for the first time. Methodology: The population included patients who met the case definition between December 2021 and February 2022. Identification of serotypes will be reduced by multiplex qRT-PCR. Results: 72 patients were identified, of which 53 (74%) were confirmed by serology (Ag NS1). The predominant serotype was DENV-2 (94%), and 6% was DENV-1. Patients between 19 and 45 years old presented the highest percentage of cases (59%). The most frequent symptoms were fever, headache, myalgia and arthralgia; 23% presented severe abdominal pain. Conclusion: This was the first confirmed dengue outbreak in the Balsas district, with DENV-2 being the main cause of the outbreak, highlighting the need to improve surveillance in areas without autochthonous transmission of the disease.
Caracterizacion y manejo de los pacientes que consultan por dolor agudo en un servicio de urgencias
Authors: Oliveros M. Johana Carolina , Duque Carlos Alberto , Vanegas R. Gloria Angelica
Published: September 2023

Objetivos: Describir las características de los pacientes que consultan por dolor agudo al servicio de urgencias y el manejo que se realiza en una institución de tercer nivel de la ciudad de Manizales. Material y Métodos: Análisis descriptivo con muestreo no probabilístico por conveniencia tomado de forma prospectiva de personas mayores de 18 años con dolor menor a 6 semanas de evolución, que consultaron a un servicio de urgencias entre noviembre de 2022 y enero de 2023. Resultados: Se recolecto un total de 254 de esos se excluyeron 15 pacientes para un total de 239 pacientes estudiados. El sexo predominante en la consulta fue el femenino con 62,8%, no se encontraron diferencias significativas en la severidad de la escala de ingreso de dolor entre hombres y mujeres. Del análisis de la prevalencia del origen de dolor el mayor número de ingresos se debió a eventos no traumáticos (n = 181; 75,7%), y en cuanto a la localización, el dolor abdominal es el más prevalente (n: 102; 42,7%). Conclusiones: La mayor prevalencia de dolor de origen no traumático, es una población joven, con pocas comorbilidades cardiovasculares. Los AINES son los analgésicos más utilizados independiente de la severidad del dolor al ingreso. Se registró una baja proporción de revaloraciones en cuanto a la efectividad del manejo analgésico
Modelo biológico tisular en el proceso de enseñanza con residentes de anestesiología
Authors: Calva Maldonado Miguel , Julio Cesar Pablo Yáñez , Fragoso Avilés Fabian , Fernández de Lara García Alfredo , Bautista Ordoñez Samantha , Sosa Rodríguez Francisco Javier
Published: September 2023

Introducción: La investigación en medicina se basa fundamentalmente en tres fuentes de conocimiento: en primer lugar, el hombre enfermo que es la fuente natural del conocimiento en la clínica, en segundo lugar, el cadáver, que es la fuente de conocimiento de la anatomía patológica y, por último, el animal de experimentación que es la fuente del conocimiento de la fisiopatología; para poder realizar esto con seguridad se puede utilizar, en el caso de la cirugía, la simulación con los modelos biológicos. Objetivo: Describir la experiencia con el uso de un modelo biológico de tipo tisular en el aprendizaje de las referencias anatómicas, características morfológicas de la columna lumbar, técnica de bloqueo epidural y subaracnoideo. Material y Métodos: Estudio observacional, prospectivo, longitudinal, multicéntrico, la muestra por conveniencia en el que participaron 20 residentes de primer grado de anestesiología de tres diferentes centros hospitalarios. Resultados: Adecuada aceptación por parte de los participantes con un promedio en la escala de Likert de 8,6 (98% de los participantes) y como resultado global del modelo de 9 en dicha escala (98% de los participantes). Discusión: Los modelos biológicos suponen la ascensión de un nuevo escalón en la complejidad del modelo, la utilización de material biológico implica la incorporación de fenómenos homeostáticos propios de este material cuyos efectos pueden ser difíciles de controlar y predecir. Conclusión: El diseño de modelos de instrucción para la enseñanza de competencias psicomotoras tiene fundamentos científicos relevantes que se deben tener en cuenta para garantizar el aprendizaje.
Manejo de la vía aérea difícil por residentes de anestesiología
Authors: Lasso Andrade Fabricio Andres , Borrero Cortés Crystian , Olarte Luis Tatiana
Published: September 2023

Introducción: La vía aérea difícil es una emergencia médica grave que puede causar lesiones neurológicas y la muerte. Es crucial entrenarse y contar con dispositivos avanzados para manejarla, especialmente durante la pandemia de COVID-19. Objetivo: Describir el entrenamiento y la experiencia en casos de vía aérea difícil en los residentes de programas de anestesiología de Colombia durante la pandemia de COVID-19. Métodos: Estudio descriptivo, retrospectivo de corte transversal que se realizó mediante una encuesta aplicada a través de QuestionPro. Se exploraron contenidos programáticos, nivel de exposición a casos complejos y satisfacción con el entrenamiento en manejo de la vía aérea en pacientes generales y en pacientes COVID-19. La muestra fue seleccionada a conveniencia y el protocolo del estudio fue aprobado por el Comité de Ética del Hospital Universitario Nacional de Colombia. Resultados: Este estudio encontró que el 54,4% de los residentes de anestesiología informó haber recibido capacitación específica sobre el manejo de la vía aérea difícil y dispositivos avanzados de vía aérea. Durante la pandemia de COVID-19, la mayoría de los residentes informaron haber manejado 2 casos de vía aérea difícil y sentirse inadecuadamente preparados. La mayoría de los hospitales carecían de equipos especializados siendo el videolaringoscopio el dispositivo más comúnmente usado en pacientes sospechosos o confirmados de COVID-19. Conclusiones: En este estudio la mayoría de los residentes de anestesiología en Colombia tienen una capacitación insuficiente en el manejo de vía aérea difícil y en el uso de dispositivos avanzados.
Highly Potent and Skin-Compatible Antimicrobial Coating via In Situ Self-Assembly of Copper Iodide Clusters
Authors: Chen Adrielle Xianwen , Beins Devina Krystel Ravichandran , Wang Yue , Luo He-Kuan , Yang Yi Yan , Li Ning
Published: September 2023

Cotton fabrics and textiles are ubiquitously useful in the household, healthcare, and commercial settings, but they may harbor a host of disease-causing pathogens due to the absence of intrinsic antimicrobial property. Copper-derived microbicidal coatings on flexible cotton substrates have drawn extensive interest. However, most of these coatings necessitate long contact times and high dosing levels to achieve complete elimination of pathogens, limiting their effectiveness against highly contagious viruses and bacteria. This study reports a highly potent antiviral and antibacterial coating fabricated in situ on commercial cotton fabrics. Constituting only 0.36wt.% relative to the substrate, the hydrophilic coating imparted by the self-assembled hexagonal nano-disks of [Cu4I4(TPP)4] (TPP = triphenylphosphine) clusters on cotton is able to eliminate >99.9% of murine hepatitis coronavirus (MHV, a SARS-CoV surrogate) and clinical isolate of the Gram-positive methicillin-resistant Staphylococcus aureus (MRSA) within 2 min. Direct surface contact was experimentally verified to be the mechanism of action, whereby the coating induced disruption of the bacterial cell membrane. More remarkably, the coating is colorless, durable, skin-compatible, and easy to scale up, making it a promising technology to enhance our preparedness towards future global outbreaks of infectious diseases.
CatScore: A High-Efficiency Evaluation Metric for Asymmetric Catalyst Design
Authors: Yan Bing , Cho Kyunghyun
Published: September 2023

Asymmetric catalysis plays a crucial role in advancing medicine and materials science. However, the prevailing experiment-driven methods for catalyst evaluation are both resource-heavy and time-consuming. To address this challenge, we present CatScore - a learning-centric metric designed for the automatic evaluation of catalyst design models at both instance and system levels. This approach harnesses the power of deep learning to predict product selectivity as a function of reactants and the proposed catalyst. The predicted selectivity serves as a quantitative score, enabling a swift and precise assessment of a catalyst’s activity. On an instance level, CatScore’s predictions correlate closely with experimental outcomes, demonstrating a Spearman’s ρ = 0.84, which surpasses the density functional theory (DFT) with ρ = 0.54 and round-trip accuracy metrics at ρ = 0.24. Importantly, when ranking catalyst candidates, CatScore achieves a mean reciprocal ranking significantly superior to traditional DFT methods, marking a considerable reduction in labor and time investments needed to find top-performing catalysts.
Synergistic Application of Molecular Docking and Machine Learning for Improved Protein-Ligand Binding Pose Prediction
Authors: Yang He , Lin Hongrui , Yuan Yannan , Li Yaqi , Zou Rongfeng , Zhou Gengmo , Zhang Linfeng , Zheng Hang
Published: September 2023

Accurate prediction of protein-ligand complex structures is a crucial step in structure-based drug design. Traditional molecular docking methods exhibit limitations in terms of accuracy and sampling space, while relying on machine-learning approaches may lead to invalid conformations. In this study, we propose a novel strategy that combines molecular docking and machine learning methods. Firstly, the protein-ligand binding poses are predicted using the Uni-Mol Docking machine learning approach. Subsequently, position-restricted docking(PR Docking) on predicted binding poses is performed using Uni-Dock, generating physically constrained and valid binding poses. Finally, the binding poses are re-scored and ranked using machine learning scoring functions. This strategy harnesses the predictive power of machine learning and the physical constraints advantage of molecular docking. Evaluation experiments on multiple datasets demonstrate that, compared to using molecular docking or machine learning methods alone, our proposed strategy can significantly improve the success rate and accuracy of protein-ligand complex structure predictions. This strategy is avaliable at https://github.com/dptech-corp/Uni-Dock.
Development of HILIC-MS/MS method for acyl-CoAs covering short- to long-chain species in a single analytical run
Authors: Singh Madhulika , Kiyuna Ligia Akemi , Odendaal Christoff , Bakker Barbara M. , Harms Amy C , Hankemeier Thomas
Published: September 2023

Acyl-CoAs play a significant role in numerous physiological and metabolic processes making it important to assess their concentration levels for evaluating metabolic health. Considering the important role of acyl-CoAs, it is crucial to develop an analytical method that can analyze these compounds. Due to the structural variations of acyl-CoAs, multiple analytical methods are often required for comprehensive analysis of these compounds, which increases complexity and the analysis time. In this study, we have developed a method using a zwitterionic HILIC column that enables the coverage of free CoA and short- to long-chain acyl-CoA species in one analytical run. Initially, we developed the method on a QTOF instrument for the identification of acyl-CoA species, optimizing their chromatography and retention times. Later, a targeted HILIC-MS/MS method was created in scheduled multiple reaction monitoring mode on a QTRAP instrument. The performance of the method was evaluated based on various parameters such as linearity, precision, recovery and matrix effect. This method was applied to identify the difference in acyl-CoA profiles in HepG2 cells cultured in different conditions. Our findings revealed an increase in levels of acetyl-CoA, medium- and long-chain acyl-CoA while a decrease in the profiles of free CoA in the starved state, indicating a clear alteration in the fatty acid oxidation process.
Engineering Pt-Pt coordination environment to enhance the four-electron oxygen reduction reaction
Authors: Marlow Sushila , Darby Matthew T. , Xu Ruoyu , Kang Liqun , Gu Hao , Wang Bolun , Allen Christopher S. , Asakura Hiroyuki , Stamatakis Michail , Wang Feng Ryan
Published: September 2023

The oxygen reduction reaction (ORR) in proton exchange membrane fuel cells plays an important role in the H2 economy. Pt-based alloy catalysts with tuned d-band centres are widely regarded as the most efficient catalysts. Here we report that the average size of Pt domains in a Pt-Pd alloy, described as the Pt-Pt coordination number (C.N.), may measure the coordination environment of Pt and its effect on the d-states, to serve as a key geometric descriptor for the ORR activity. The decrease of Pt-Pt C.N. from 10.8 in commercial Pt nanoparticles to 1.33 in Pt1Pd493 alloy leads to an exponential increase in the Pt mass activity from 0.18 to 4.86 A/mgPt. Density functional theory calculations show that low C.N. sites of Pt within the Pd host have low O-O dissociation barriers, favouring the four-electron dissociative pathway. The precise engineering of Pt-Pt C.N. in an alloy is critical for optimising metal use in the activation of chemically stable compounds, particularly in the context of catalysis for renewable energy.
The periodicity of nuclear magnetic moments and nucleon binding energies in light nuclides: Implications for nuclear structure
Authors: Walsh Ray
Published: September 2023

The atomic nucleus contains protons and neutrons surrounded by a structured electron cloud. Some combinations of protons and neutrons induce the nucleus to behave like a microscopic magnet, possessing a unique magnitude and orientation known as the nuclear magnetic moment (µ). When the numbers of protons and neutrons are both even then µ=0, but otherwise each nuclide nuclear magnetic moment is unique. A second unique nuclear physical property relates to the nucleon binding energy (BE), which can be thought of as the energy between protons and neutrons bound within the nucleus. The sequence of stable nuclides increases one nucleon at a time through 36Ar. The binding energy associated with the addition of each successive nucleon (∆BE) through this progression is unique. The hypothesis here is that the unique non-zero magnetic moment and ∆ binding energy of each nuclide derive from its respective microscopic nuclear structure, analogous to the way that the atomic physical properties of an element ultimately derive from its unique electron orbital structure. By extension, the identification of nuclear periodic patterns might eventually inform a theory of nuclear structure. The light, stable nuclides through 36Ar were arranged in ascending order according to atomic mass, and their nuclear magnetic moments and binding energies were evaluated for periodic patterns. Fixed-period lengths from 4 through 18 nuclides per period were considered. These fixed periods, each of equal length, were stacked one upon the other and analyzed for vertical trends. The best evidence of periodicity in both µ and ∆BE converges precisely at the fixed 12-nuclide period. Implications for nuclear structure are discussed.
Phospha-cyanines in their Ideal Polymethine State: Synthesis and Structure-Properties Relationships
Authors: Chemin Alexandre , Knysh Iryna , Ari Denis , cordier marie , Roisnel Thierry , Le Guennic Boris , Hissler Muriel , Jacquemin Denis , Bouit Pierre-Antoine
Published: September 2023

We report the synthesis and full characterization of a family of phosphorus containing polymethine cyanines (phospha-cyanines). The compounds are easily prepared in two steps starting from readily available phosphanes. The impact of the P-substituents and the counterions on the structural and optical properties is investigated through a joint experimental/theoretical approach. Based on the study of the single crystal X-ray diffraction structures, all phospha-cyanines present a bond length alternation (BLA) close to zero, independently of the substituent and the counterions, which indicates an ideal polymethine state. All these compounds display the typical cyanine-like UV-vis absorption with an intense and sharp transition with a vibronic shoulder. TD-DFT calculations allowed to fully rationalize the optical properties (absorption/emission wavelengths, luminescence quantum yields). Interestingly, due to the tetrahedral shape of the P-atom, the optical properties are independent of the counterion, which is in marked contrast with N-analogs, which enables predictive engineering of the phospha-cyanines regardless of the medium in which they are used.