bluuebunny/crossref_metadata_2025 huggingface dataset:
Harmol used for the treatment of herpes simplex virus induced keratitis
Authors: Xu Huanhuan , Zhou Nan , Huang Zhenping , Wu Jing , Qian Yajie
Published: May 2024

Herpes simplex virus type 1 (HSV-1) infection of the eyes results in herpes simplex keratitis (HSK), which has led to vision loss and even blindness in patients. However, the rate of drug resistance in HSV is on the rise; therefore, new antiviral agents with sufficient safety profiles must be developed. At present, we assessed the anti-HSV-1 activity of 502 natural compounds and their ability to reduce the HSV-1-induced cytopathic effect. We chose harmol for further studies because it exhibited the highest antiviral activity. We found that harmol inhibited both HSV-1 F and HSV-1/153 (a clinical drug-resistant strain) replication, with an EC50 of 9.34 µM and 5.84 µM, respectively. Moreover, harmol reduced HSV-1 replication in corneal tissues and viral progeny production in tears, and also alleviated early corneal surface lesions related to HSK. For example, harmol treatment preserved corneal thickness and nerve density in HSK mice. Interestingly, harmol also showed a promising antiviral effect on HSV-1/153 induced HSK in mouse model. Furthermore, harmol combined with acyclovir (ACV) treatment showed a greater antiviral effect than either one alone in vitro. Therefore, harmol may be a promising therapeutic agent for managing HSK.
A non-invasive preoperative prediction model for predicting axillary lymph node metastasis in breast cancer based on a machine learning approach: combining ultrasonographic parameters and breast gamma specific imaging features
Authors: Cai Ranze , Deng Li , Zhang Hua , Zhang Hongwei , Wu Qian
Published: May 2024

Background

The most common route of breast cancer metastasis is through the mammary lymphatic network. An accurate assessment of the axillary lymph node (ALN) burden before surgery can avoid unnecessary axillary surgery, consequently preventing surgical complications. In this study, we aimed to develop a non-invasive prediction model incorporating breast specific gamma image (BSGI) features and ultrasonographic parameters to assess axillary lymph node status.

Materials and methods

Cohorts of breast cancer patients who underwent surgery between 2012 and 2021 were created (The training set included 1104 ultrasound images and 940 BSGI images from 235 patients, the test set included 568 ultrasound images and 296 BSGI images from 99 patients) for the development of the prediction model. six machine learning (ML) methods and recursive feature elimination were trained in the training set to create a strong prediction model. Based on the best-performing model, we created an online calculator that can make a linear predictor in patients easily accessible to clinicians. The receiver operating characteristic (ROC) and calibration curve are used to verify the model performance respectively and evaluate the clinical effectiveness of the model.

Results

Six ultrasonographic parameters (transverse diameter of tumour, longitudinal diameter of tumour, lymphatic echogenicity, transverse diameter of lymph nodes, longitudinal diameter of lymph nodes, lymphatic color Doppler flow imaging grade) and one BSGI features (axillary mass status) were selected based on the best-performing model. In the test set, the support vector machines’ model showed the best predictive ability (AUC = 0.794, sensitivity = 0.641, specificity = 0.8, PPV = 0.676, NPV = 0.774 and accuracy = 0.737). An online calculator was established for clinicians to predict patients’ risk of ALN metastasis (https://wuqian.shinyapps.io/shinybsgi/). The result in ROC showed the model could benefit from incorporating BSGI feature.

Conclusion

This study developed a non-invasive prediction model that incorporates variables using ML method and serves to clinically predict ALN metastasis and help in selection of the appropriate treatment option.
Objective and automatic assessment approach for diagnosing attention-deficit/hyperactivity disorder based on skeleton detection and classification analysis in outpatient videos
Authors: Ouyang Chen-Sen , Yang Rei-Cheng , Wu Rong-Ching , Chiang Ching-Tai , Chiu Yi-Hung , Lin Lung-Chang
Published: May 2024

Background

Attention-deficit/hyperactivity disorder (ADHD) is diagnosed in accordance with Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition criteria by using subjective observations and information provided by parents and teachers. However, subjective analysis often leads to overdiagnosis or underdiagnosis. There are two types of motor abnormalities in patients with ADHD. First, hyperactivity with fidgeting and restlessness is the major diagnostic criterium for ADHD. Second, developmental coordination disorder characterized by deficits in the acquisition and execution of coordinated motor skills is not the major criterium for ADHD. In this study, a machine learning-based approach was proposed to evaluate and classify 96 patients into ADHD (48 patients, 26 males and 22 females, with mean age: 7y6m) and non-ADHD (48 patients, 26 males and 22 females, with mean age: 7y8m) objectively and automatically by quantifying their movements and evaluating the restlessness scales.

Methods

This approach is mainly based on movement quantization through analysis of variance in patients’ skeletons detected in outpatient videos. The patients’ skeleton sequence in the video was detected using OpenPose and then characterized using 11 values of feature descriptors. A classification analysis based on six machine learning classifiers was performed to evaluate and compare the discriminating power of different feature combinations.

Results

The results revealed that compared with the non-ADHD group, the ADHD group had significantly larger means in all cases of single feature descriptors. The single feature descriptor “thigh angle”, with the values of 157.89 ± 32.81 and 15.37 ± 6.62 in ADHD and non-ADHD groups (p < 0.0001), achieved the best result (optimal cutoff, 42.39; accuracy, 91.03%; sensitivity, 90.25%; specificity, 91.86%; and AUC, 94.00%).

Conclusions

The proposed approach can be used to evaluate and classify patients into ADHD and non-ADHD objectively and automatically and can assist physicians in diagnosing ADHD.
Blocking miR396 activity by overexpression MIM396 improved switchgrass tiller number and biomass yield
Authors: Xu Mingzhi , Li Lin , Yan Jianping , Li Dayong , Liu Yaling , Zhang Wanjun , Liu Yanrong
Published: May 2024

Background

MicroRNA396 (miR396) plays an important role in the regulation of plant growth and development by repressing the expression level of its target growth-regulating factor (GRF) family genes. In our previous study, we found that overexpression of miR396 negatively regulated both tillering and biomass yield in switchgrass (Panicum virgatum L.). We, therefore, speculated that blocking the expression of miR396 could enhance switchgrass tillering and biomass yield. Here, we produced transgenic switchgrass plants overexpressing a target mimicry form of miR396 (MIM396) in wild type (WT) and Os-MIR319b overexpressing switchgrass plant (with higher enzymatic hydrolysis efficiency, but reduced tillering), in which the expression of miR396 was blocked. The phenotype and biological yields of these plants were analyzed.

Results

Blocking miR396 to improve its target PvGRFs expression in switchgrass improved the tiller number and dry weight of transgenic plants. Further morphological analysis revealed that MIM396 plants increased the number of aerial branches and basal tillers compared to those of wild-type plants. The enzymatic efficiency of MIM396 plants was reduced; however, the total sugar production per plant was still significantly higher than that of wild-type plants due to the increase in biomass. In addition, blocking miR396 in a transgenic switchgrass plant overexpressing Os-MIR319b (TG21-Ms) significantly increased the PvGRF1/3/5 expression level and tiller number and biomass yield. The miR156-target gene PvSPL4, playing a negative role in aerial and basal buds outgrowth, showed significant downregulated in MIM396 and TG21-Ms. Those results indicate that miR396-PvGRFs, through disrupting the PvSPL4 expression, are involved in miR319-PvPCFs in regulating tiller number, at least partly.

Conclusions

MIM396 could be used as a molecular tool to improving tiller number and biomass yield in switchgrass wild type and miR319b transgenic plants. This finding may be applied to other graminaceous plants to regulate plant biological yield.
Epidemiological trends in psoriatic arthritis: a comprehensive population-based study
Authors: Haddad Amir , Elkayam Perach Chen , Stein Nili , Feldhamer Ilan , Cohen Arnon Dov , Saliba Walid , Zisman Devy
Published: May 2024

Background

Psoriatic arthritis (PsA) is a chronic, potentially debilitating inflammatory arthritis often associated with psoriasis. Understanding the epidemiology of PsA across diverse populations can provide valuable insights into its global burden and the role of genetic and environmental factors. This study aimed to estimate PsA’s temporal trends, prevalence, and incidence, while assessing variations in age, gender, and ethnicity in Israel from 2016 to 2022.

Methods

Data were sourced from the Clalit Health Services (CHS) database, covering over half of the Israeli population. Algorithm-based definitions for PsA and psoriasis cases were used. Demographic factors, including age, gender, socioeconomic status (SES), ethnicity, urban/rural residence, BMI, and smoking status, were analyzed. Standardized prevalence and incidence rates were calculated. Logistic regression analyses examined associations of sociodemographic variables with PsA.

Results

In 2022, the prevalence of PsA was 0.221%, with an incidence rate of 13.54 per 100,000 population. This prevalence has tripled since 2006, reflecting a rising trend in PsA over time. Females exhibited a higher prevalence (1.15; 95%CI 1.09–1.21), and PsA was more common in Jewish individuals (1.58; 95%CI 1.45–1.71) those with higher SES (1.4; 95% CI 1.31, 1.5), and those with obesity (2.17; 95%CI 2.04–2.31).

Conclusions

This comprehensive population-based study pointed to an increase prevalence of PsA, emphasizing the rising healthcare demands and economic burden faced by this patient population. Further research is essential to delve into the factors driving these trends.
TransExION: a transformer based explainable similarity metric for comparing IONS in tandem mass spectrometry
Authors: Bui-Thi Danh , Liu Youzhong , Lippens Jennifer L. , Laukens Kris , De Vijlder Thomas
Published: May 2024

Small molecule identification is a crucial task in analytical chemistry and life sciences. One of the most commonly used technologies to elucidate small molecule structures is mass spectrometry. Spectral library search of product ion spectra (MS/MS) is a popular strategy to identify or find structural analogues. This approach relies on the assumption that spectral similarity and structural similarity are correlated. However, popular spectral similarity measures, usually calculated based on identical fragment matches between the MS/MS spectra, do not always accurately reflect the structural similarity. In this study, we propose TransExION, a Transformer based Explainable similarity metric for IONS. TransExION detects related fragments between MS/MS spectra through their mass difference and uses these to estimate spectral similarity. These related fragments can be nearly identical, but can also share a substructure. TransExION also provides a post-hoc explanation of its estimation, which can be used to support scientists in evaluating the spectral library search results and thus in structure elucidation of unknown molecules. Our model has a Transformer based architecture and it is trained on the data derived from GNPS MS/MS libraries. The experimental results show that it improves existing spectral similarity measures in searching and interpreting structural analogues as well as in molecular networking.

Scientific Contribution

We propose a transformer-based spectral similarity metrics that improves the comparison of small molecule tandem mass spectra. We provide a post hoc explanation that can serve as a good starting point for unknown spectra annotation based on database spectra.
Revealing the unseen: advanced digital imaging and spectroscopy for the documentation and non-invasive analysis of a 16th-century Cypriot composite icon
Authors: Zaprzalska Dorota , Georgiou Ropertos , Gasanova Svetlana , Bakirtzis Nikolas
Published: May 2024

The present study focuses on an icon known as the Panagia Valieriotissa at the Church of Saint Nicholas in Palodeia, Cyprus. The icon is unusual as it contains two depictions of the Virgin Mary and Child. The main aim of this study is to analyze the material characteristics of the icon and the relation of the two panels in order to determine if the icon belongs to a distinct category of paintings known as “composite icons” – icons consisting of two separate panels, one inserted into another. Icons of this unusual type, first described by Panayotis Vocotopoulos, appear to be quite numerous on Cyprus and date mostly to the sixteenth century. Results show that the icon can be included within this group, consequently enriching our knowledge on the materials, technologies, and techniques used in the creation of composite icons. Driven by art historical inquiries, the study’s methodological approach was based on the integration of digital imaging techniques with non-invasive and non-destructive material analyses pursued by the Andreas Pittas Art Characterization Laboratories (APAC Labs) of the Cyprus Institute. Spectroscopic techniques, digital microscopy and advanced digital imaging methods produced a broad range of data which were analyzed and interpreted from both an art-historical and a conservation perspective towards a better understanding of the materiality of the Palodeia icon and its subsequent history and use. The imaging and spectroscopic methods used provided new information on the materials and techniques used by the painters as well as on later undocumented episodes of restoration or repainting. Overall, the results showed that the icon indeed consists of two separate icons – a larger panel and a smaller, re-used icon inserted into the former. Moreover, some important distinctive features of the inset icon, invisible to the naked eye, reveal its possible previous use and dating. The study brought to light the great potential of non-invasive methods in the revealing and analysis of unknown aspects of composite icons, thus shedding light on this fascinating phenomenon, but it can also interest a broader group of researchers into the exciting new possibilities as well as the limitations of non-invasive methods for the study of works of art and heritage objects.
Interactive 360° media for the dissemination of endangered world heritage sites: the ancient city of Palmyra in Syria
Authors: Dieb Rida , Alsalloum Ataa , Webb Nicholas
Published: May 2024

Since the onset of conflict in Syria in 2011, several heritage sites have suffered partial or complete destruction. The ancient city of Palmyra, a UNESCO World Heritage Site since 1980, was placed on the List of World Heritage in Danger in 2013, alongside five other Syrian heritage sites. Between 2015 and 2017, Palmyra experienced the loss of nearly 40% of its historic buildings and landmarks. The site’s remote location and ongoing armed conflict pose additional challenges in accessing and preserving it.

This paper introduces an interactive online platform employing 360° media to document and disseminate information about the world heritage site of Palmyra. The platform contributes to the safeguarding process of Palmyra, facilitating public engagement and interaction with the site. It also has potential applications for other sites in Syria and beyond. The platform allows users to explore both archival and current information of damaged historical monuments and buildings, revealing their layered histories before and after demolition. Employing interactive 360° media, similar to applications like Google Street View, the platform offers a reality-based digital environment. Users can virtually move into different buildings or follow specific pathways within the site, accessing archival information and documentation about particular monuments and buildings along their journey.

This project serves as a unique informational resource for decision-makers and policy planners, aiding in the understanding of the site and the development of relevant strategies and recommendations. It also proves beneficial as an educational tool. The collective understanding fostered by this platform is expected to positively influence post-conflict restoration and reconstruction plans, making it an invaluable asset for research and educational purposes.
Analysis of Treatment Strategies and Outcomes in Malignant Peritoneal Mesothelioma: Insights From a Multi-Center Study
Authors: Yaşar Serkan , Yılmaz Feride , Utkan Güngör , Algın Efnan , Bayram Doğan , Tamam Selim , Öksüzoğlu Ömür Berna Çakmak , İlhan Ayşegül , Erdat Efe Cem , Ünal Ali Ekrem , Yalçın Şuayib
Published: May 2024

Background

This study aimed to evaluate the demographic,” clinicopathologic, and prognostic characteristics of malignant peritoneal mesothelioma (MPeM), as well as the treatment options for the rare and heterogeneous MPeM population.

Methods

A retrospective multi-center observational cohort study was conducted to evaluate patients with MPeM. Due to the heterogeneity of the study population, the study divided them into two main groups in terms of treatments, follow-up periods, and prognostic features. The first group comprised the patients who underwent cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC), and the second group included the patients with metastatic disease for whom curative intent surgery was not possible. The patients’ diagnostic procedures and treatments were identified from medical records. Patients older than 18 years old were included in the study regardless of asbestos exposure. Well-differentiated papillary and multicystic mesothelioma histologic types were not included in the study.

Results

The study evaluated 118 patients from five centers. Survival times, prognosis, and treatment responses were analyzed in both groups. The study showed that CRS-HIPEC was associated with longer overall survival (OS) and progression-free survival (PFS). Perioperative therapy was evaluated in subgroup analyses of this population and shown to provide survival benefits. The patients treated with chemotherapy (metastatic and medically inoperable patients and those for whom complete cytoreduction was not achievable) had a poorer prognosis than the surgery group. The study showed that life expectancy decreased significantly for the patients not suitable to undergo surgery for any reason.

Conclusions

According to data from experienced centers, CRS-HIPEC is a treatment option recognized as effective, cost-effective, and safe, with better OS and PFS , as well as low morbidity and mortality rates similar to those in the literature. In addition, the platinum-pemetrexed combination continues to be an effective and acceptable treatment option for metastatic patients, those who are medically inoperable, and those for whom complete or near-complete cytoreduction is not achievable.
Διαταραχές της αιμόστασης σε ασθενείς που υποβάλλονται σε στεφανιογραφία
Authors: Τσιουραντάνη Φωτεινή
Published: May 2024

Η στεφανιογραφία αποτελεί μία μη χειρουργική, διαδερμική τεχνική που χρησιμοποιείται για τη διάγνωση και τη θεραπευτική αντιμετώπιση της αποφρακτικής στεφανιαίας νόσου. Κύρια ένδειξη διενέργειάς της αποτελεί το οξύ στεφανιαίο σύνδρομο, στο οποίο συμπεριλαμβάνονται το οξύ έμφραγμα του μυοκαρδίου με ανάσπαση του ST διαστήματος, το οξύ έμφραγμα του μυοκαρδίου χωρίς ανάσπαση του ST διαστήματος (Non-ST- Elevation Myocardial Infarction, NSTEMI) και η ασταθής στηθάγχη. Η χρήση εργαστηριακών μεθόδων για την ανίχνευση και μέτρηση των παραγόντων που συμμετέχουν στον πηκτικό μηχανισμό επί ενδοθηλιακής δυσλειτουργίας σε ασθενείς με στεφανιαία νόσο, μπορεί να οδηγήσει σε σημαντικά συμπεράσματα ως προς τη συμμετοχή της ενδοθηλιακής λειτουργίας στις αθηροσκληρωτικές αλλοιώσεις των στεφανιαίων αρτηριών στον συγκεκριμένο πληθυσμό ασθενών. Ο στόχος της συγκεκριμένης διδακτορικής διατριβής είναι να διερευνηθούν οι διαταραχές του πηκτικού μηχανισμού και η σημασία της ενδοθηλιακής δυσλειτουργίας σε ασθενείς που πρόκειται να υποβληθούν σε στεφανιογραφία. Οι ασθενείς κατηγοριοποιήθηκαν σε τρεις ομάδες: 1) ασθενείς με NSTEMI, 2) ασθενείς με ασταθή στηθάγχη και 3) ασθενείς με σταθερή στηθάγχη και θετική δοκιμασία προκλητής ισχαιμίας (control group). Στους ασθενείς κάθε ομάδας πραγματοποιήθηκε αιμοληψία για βασικό αιματολογικό και βιοχημικό έλεγχο, καθορισμό του λιπιδαιμικού προφίλ, μέτρηση της C- αντιδρώσας πρωτεΐνης υψηλής ευαισθησίας (high- sensitivity C- reactive protein, hs- CRP) και των βιοδεικτών μυοκαρδιακής νέκρωσης (τροπονίνη Ι και CK-MB). Ακολούθησε μέτρηση της δραστικότητας του παράγοντα von Willebrand (von Willebrand Factor, vWF), της δραστικότητας της μεταλλοπρωτεάσης ADAMTS13 (Α Disintegrin and Metalloproteinase with a Thrombospondin type 1 motif, member 13) καθώς και μέτρηση της θρομβομοντουλίνης και της μυελοϋπεροξειδάσης, ως δείκτες της ενδοθηλιακής βλάβης και ως παράγοντες ανοσοθρόμβωσης. Η ανίχνευση και μέτρηση των προθρομβωτικών παραγόντων και ενζύμων που συμμετέχουν στη διαδικασία της πήξης πραγματοποιήθηκε με ειδικές εργαστηριακές μεθόδους (με την ανοσοενζυμική μέθοδο της ELISA, Enzyme- Linked ImmunoSorbent Assay και με λειτουργικές δοκιμασίες της πήξης). Ο σκοπός της συγκεκριμένης διδακτορικής διατριβής είναι να προσθέσει στην υπάρχουσα βιβλιογραφία δεδομένα σχετικά με τη σημασία της διαταραχής της πήξης, της ενδοθηλιακής βλάβης και της ανοσοθρόμβωσης σε ειδικές ομάδες ασθενών πριν τη διενέργεια της αγγειογραφίας των στεφανιαίων αγγείων και την πιθανή επακόλουθη αγγειοπλαστική, καθώς και τη συσχέτιση της παρουσίας των παραγόντων αυτών με τα ευρήματα του στεφανιογραφικού ελέγχου. Επιπρόσθετα, στόχος ήταν η σύγκριση των αποτελεσμάτων των δεικτών ενδοθηλιακής βλάβης για κάθε παράγοντα καρδιαγγειακού κινδύνου των ασθενών. Οι παράγοντες κινδύνου που μελετήθηκαν ξεχωριστά ήταν το κάπνισμα, ο σακχαρώδης διαβήτης, η δυσλιπιδαιμία, η αρτηριακή υπέρταση, η περιφερική αρτηριακή νόσος, η χρόνια νεφρική νόσος και το οικογενειακό ιστορικό στεφανιαίας νόσου.
Βασιλόπαιδες πατριάρχες Κωνσταντινουπόλεως
Authors: Δοϊρανλή Άννα
Published: May 2024

Η μελέτη ασχολείται με τους τρεις βασιλόπαιδες που ανήλθαν στον αρχιεπισκοπικό θρόνο της Κωνσταντινούπολης, τον Ιγνάτιο Ραγκαβέ, τον Στέφανο Μακεδόνα και τον Θεοφύλακτο Λεκαπηνό, οι οποίοι θήτευσαν από τα μέσα του 9ου αιώνα μέχρι τα μέσα του 10ου αιώνα. Περιλαμβάνει μία σχετικά εκτενή εισαγωγή, προκειμένου να συνδράμει στο θέμα των πηγών, οι οποίες δημιούργησαν δυσκολίες λόγω των αναθεωρήσεων σχετικά με την πατρότητά τους. Το κυρίως κείμενο της μελέτης δομείται σε δύο μέρη. Το πρώτο μέρος διερευνά το ιστορικό πλαίσιο και τις συνθήκες ανάρρησης για κάθε έναν βασιλόπαιδα και αναδεικνύει τις προθέσεις των αυτοκρατόρων που οδήγησαν τους βασιλόπαιδες στον αρχιεπισκοπικό θρόνο της Κωνσταντινούπολης. Συνδράμει την έρευνα σε επιμέρους ζητήματα, όπως αυτό της χρονολογικής αντιστοίχισης των απανωτών αποφάσεων και ενεργειών σχετικά με την ανάρρηση του πατριάρχη Θεοφύλακτου. Το δεύτερο μέρος της μελέτης διερευνά το νομότυπο των αναρρήσεων με βάση το κανονικό δίκαιο. Παρουσιάζει τα απαραίτητα προσόντα και την τυπική διαδικασία που ακολουθείται, προκειμένου για την εκλογή επισκόπου. Αναδεικνύει την ιδιαίτερη περίπτωση της εκλογής αρχιεπισκόπου Κωνσταντινουπόλεως και τον ρόλο του αυτοκράτορα στην εκλογή. Στις διαπιστώσεις η μελέτη παραθέτει τις αποκλίσεις που σημειώθηκαν από τους κανόνες, αντιπαραβάλλει τις τρεις περιπτώσεις και σχολιάζει, με βάση πάντα το παράδειγμα των τριών αναρρήσεων, τη σχέση Εκκλησίας-Κράτους και τον ρόλο της Εκκλησίας.
On the need to better integrate the social environment in research on climate change and health: recommendations and thinking tools
Authors: Mabile Laurence , Neufcourt Lola , Chersich Matthew , Leroy Valériane , Delpierre Cyrille , Kelly-Irving Michelle
Published: May 2024

Social inequality impacts health, is aggravated by the consequences of climate change, and may be influenced by inappropriate policy responses. These interdependent effects create a self-perpetuating loop exacerbating the impact of climate dysregulation on health in an uncontrolled and poorly understood way. Holistic approaches to public health such as One Health, EcoHealth or Planetary Health are well suited to tackling the considerable and complex environmental and social issues underlying climate dysregulation. However, the extent to which research using such frameworks investigates social determinants of health is not clear. In this paper we discuss the ways in which the social environment has so far been considered in the literature to problematize and analyze the relationship between climate dysregulation and health within holistic frameworks and provide tools and recommendations to facilitate their apprehension. Social factors are investigated empirically only in a minor fraction of studies addressing the relation between climate and health in holistic frameworks, and not systematically. Barriers to such approaches are discussed. This work also provides two analytical tools (a process diagram and a knowledge framework) and a set of recommendations to help include the social environment more meaningfully in such frameworks. They are meant to facilitate our understanding of the current status of this type of research and to encourage trans-disciplinary and trans-sectorial endeavors towards directions which need to be taken to ensure societal factors and inequalities are placed at the center of research on climate and health and the ensuing policy response.
VARIABILITY OF THE ONTOGENETIC STRUCTURE OF THE COENOPOPULATIONS OF TULIPA BIFLORA PALL. (LILIACEAE) IN KALMYKIA
Authors: Lidzhieva Nina Ts. , Ochirova Aleksandra S. , Ovadykova Zhanna V.
Published: May 2024

Background. Population-ontogenetic studies are important for assessing the state of natural ecosystems, identifying and monitoring protected natural areas, forming and maintaining Red Books at the level of Regions of Russia as a whole, describing ecological and biological indicators of plant species. The species Tulipa biflora is recommended for protection in Kalmykia and many other regions of Russia.
Purpose. Study of the variability of the ontogenetic structure of T. biflora coenopopulations in Kalmykia.
Materials and methods. The research was carried out in 10 species populations of T. biflora growing in the Caspian lowland and on the Ergeninsky upland within the republic of Kalmykia during the growing seasons of 2016-2018. The ontogenetic structure of coenopopulations was studied using classical population-ontogenetic approaches and methods [8, 11, 13-15 и др.]. The ability of the coenopopulation to self-renewal was assessed using the recovery index Ib [14], the age index (Δ) [11]  and the efficiency index (ω) [1].
Results. During the three-year study period in 10 populations of T. biflora in the conditions of Kalmykia, the frequency of occurrence of plants of different age conditions was determined, ontogenetic spectra of populations and basic spectra of the species were constructed. By calculating a number of indices, the ontogenetic types of populations are determined.
Conclusion. The age structure of T. biflora cenopopulations in the conditions of Kalmykia is very dynamic, the ratio of age groups varies greatly, but fits into 1-3 ontogenetic types by year.
PREVALENCE OF HOSPITAL INFECTIONS IN THE MULTIDISCIPLINARY CHILDREN'S HOSPITAL
Authors: Alieva Ilkay H. , Aliev Mehman H.
Published: May 2024

An important factor characterizing the level of development of medicine in a particular country is the prevalence and intensity of nosocomial infections. In this regard, studies were carried out, the purpose of which was to analyze the prevalence and structure of nosocomial infections among children. Age characteristics, type of infection, as well as clinical strains of microorganisms isolated from 350 pediatric patients with pathological infectious processes, developing organs and tissues of the respiratory tract - 200 (group 1), and digestive tract - 150 patients (group 2) were studied. The frequency of occurrence of isolated bacterial cultures directly depended on the nosological form of the studied infectious pathology. In the first and second groups, the priority causative agent of nosocomial infection is Ps.aeruginosa, which was intensively sown in 41.5% and 43.33% of children, respectively. In general, the symptoms of respiratory system damage occurred more often among children included in the study and corresponding to age indicators above 10 years - 62.5%. In the same age group, a high level of damage to organs and tissues of the gastrointestinal tract was observed, which was determined by the obtained statistical data - 58.0%.
ASSOCIATION OF METABOLIC SYNDROME AND ITS COMPONENTS WITH QUALITY OF LIFE INDICATORS IN WOMEN WITH ARTERIAL HYPERTENSION
Authors: Yaskevich Roman A. , Moskalenko Olga L.
Published: May 2024

Purpose. Study of the association of metabolic syndrome and its components with quality of life indicators in women with arterial hypertension.
Materials and methods. 361 women with hypertension were examined, of which 270 had metabolic syndrome. Metabolic syndrome was diagnosed based on the criteria of clinical recommendations of the All-Russian Scientific Society of Cardiology in 2009. The assessment and the degree of quality of life reduction were carried out using the methodology developed by A.G. Gladkov et al. (1982) and adapted by T.A. Ayvazyan et al. (1989).
Results. It was found that regardless of the presence of metabolic syndrome among the examined women, the indicators of quality of life of varying degrees of decrease were found in more than 2/3 of the examined in both groups. At the same time, among women with metabolic syndrome, the number of people with a significant decrease in quality of life was higher. A decrease in quality of life in women with hypertension with MS was observed in more than 70% of the examined patients, regardless of the combination of metabolic syndrome metabolic syndrome components. In most cases, a decrease in quality of life of a woman with both normal quality of life indicators and varying degrees of its decrease was associated with the need for treatment, with dietary restrictions, with restrictions on herself in something and with a decrease in activity in everyday life.
Conclusion. It was found that in women with arterial hypertension, the metabolic syndrome was largely associated with low quality of life indicators.
PRODUCTIVITY OF OIL FLAX DEPENDING ON DOSES OF FERTILIZERS AND CORRELATION AND STATISTICAL ANALYSIS OF THE STUDY FACTORS
Authors: Podlipnaya Anastasia A. , Vinogradov Dmitry V. , Zubkova Tatyana V.
Published: May 2024

Background. The high purchase price and the expansion of treatment volumes stimulate the production of oilseeds in general, including oilseed flax. However, it has not been enough done to determine the autecological aspects in the agrocenoses of oil flax and the scientific justification for the sustainable production of oilseed raw materials of this crop in conditions of the Central Non-Black Earth Region. Also, the problem of the sowing qualities of flax, the preservation of the crop in various weather conditions of the region has not been solved and such methods of agricultural technology as the use of biological microfertilizers, including complex interaction with mineral fertilizers, have not been worked out, which determines the relevance and necessity of conducting these studies.
Materials and Methods. Research methods and methodology were based on generalization of scientific sources of domestic and foreign authors, laboratory and field studies, phenological observations, records, according to recommendations and generally accepted methods, using correlation and statistical analysis of the experimental data obtained. Microsoft Office Excel 10 was used for statistical work.
Results. The maximum average yields were found in variants with N205P35K75 (24.4 dt/ha); N220P70K105 (25.1 dt/ha) against the background of Micropolidoc Plus application. The increase in oilseeds compared to options with introduction of N125 was without Micropolidoc Plus: +6.8 dt/ha (N205R35K75) and +8.9 dt/ha (N220R70K105), and against the background of using Micropolidoc plus it was +7.9 dt/ha (N205R35K75) and +8.6 dt/ha (N220Р70К105).
Conclusion. The use of higher calculated doses of fertilizers stimulated an increase in yield, and spraying oil flax plants in the “herringbone” phase with Micropolidoc Plus microfertilizer at a dose of 0.5 l/ha, in combination with mineral fertilizers, gave a higher increase in seeds according to the options. Correlation-statistical analysis revealed that the relationship was enhanced when treated with agrochemical Micropolidoc Plus against the background of an average level of nutrition (r = 0.42), and an increase in the number of boxes per unit increased the crop yield by +0.84 dt/ha, which indicated the effectiveness of a biological product that improved conditions for increasing the responsiveness of yields to the formation of boxes.
ALTERNATIVE METHODS FOR ASSESSING USEFUL PROPERTIES OF NON-WOOD FOREST PRODUCTS
Authors: Olkova Anna S. , Tovstik Evgeniya V.
Published: May 2024

The article presents a study of pre-developed phyto-compositions for the preparation of hot drinks based on birch chaga (Inonotus obliquus) with the addition of various plant materials (herbs, berries, lichen). We used the traditional method for evaluating the beneficial properties of such products - determining the level of antioxidant activity, and not typical methods that allowed us to establish the antibacterial and antiprotozoal activity of the finished product. It was shown that the antioxidant activity in aqueous extracts from phytocompositions increased compared to extracts from monocomponents (by a maximum of 4.8 times). Biotesting methods confirmed the effect of synergism of plant components in their joint action. Antiprotozoal activity decreased only in the mixture of chaga, apples and cinnamon compared to the values for individual ingredients. Antibacterial activity was not observed in 57% of extracts from monocomponents, and when they were combined, we observed the inhibition of E. coli in all variants.
PREDICTION OF PULMONARY FIBROSIS AND THE DEVELOPMENT OF CHRONIC PULMONARY INSUFFICIENCY IN PATIENTS WHO HAVE UNDERGONE COVID-19
Authors: Balinyan Diana B. , Efremova Olga A. , Kamyshnikova Lyudmila A. , Dubrova Vladislav A. , Blagov Alexey Yu.
Published: May 2024

After recovering from COVID-19, many patients complain about their health. Transferring Covid-19 does not mean that you can now forget about hospitals. Most people just remember about them. Complications after the virus are no less dangerous than the disease itself. Therefore, patients who have undergone coronavirus undergo in-depth medical examination. While we are feverishly developing an effective treatment for the acute phase of the virus, we should not forget about the serious consequences of the COVID-19. To do this, we will consider and try to analyze the most dangerous complications after COVID-19.
Purpose. To describe the results of the COVID-19 pandemic for the recovered, with a focus on the great need to identify biomarkers that contribute to identifying patients who may develop fibrous interstitial pulmonary pathology (pulmonary fibrosis) at the initial stage of the disease.
When detecting COVID-19 manifestations and performing further treatment, it should be borne in mind that the infectious process after the virus is eliminated from the body in most cases does not stop and can turn into long-term lung damage, in particular, fibrous interstitial lung disease.
In the literary review, the analysis of modern Russian and foreign (exclusively in English) scientific works significant in relation to the topic of the review and presented in the databases eLibrary, PubMed, Scopus and in the scientific electronic library "Cyberleninka" (Cyberleninka) is carried out.
COMPARATIVE ANALYSIS OF INDICATORS OF ECONOMIC EF-FICIENCY OF CULTIVATION OF CHERRY SEEDLINGS WITH DRIP IRRIGATION
Authors: Nikolskaya Olga A. , Seminchenko Elena V. , Solonkin Andrey V.
Published: May 2024

Background. The increase in fruit production to a deficit-free volume of consumption by the population and the needs of industrial processing is due to the need to expand the area of garden plantings. An integral part of the organization of the laying of garden plantings is the nursery industry that grows planting material. A lot depends on the quality of the planting material. The choice of a seedling affects the further growth, development, fruiting, yield and immunity of the future fruit tree. In the conditions of a nursery of stone crops of open ground, it is important to determine the irrigation regime, which, in combination with the use of fertilizers, will provide the highest yield of seedlings while saving all types of resources.
Purpose. To determine the economic efficiency indicators of the recommended irrigation technology in combination with mineral fertilizing of cherry seedlings. The assessment of economic efficiency in our experiments was carried out by calculating the profit received, taking into account all costs in the nursery and the level of profitability.
Materials and methods. The object of research was annual cherry seedlings of the Vasilisa variety. The scheme of two-factor experience provided for the study of three options for each factor. Factor A is the water regime of the soil and factor B is mineral fertilizing.
Results. It has been proved that when growing seedlings of stone crops on light chestnut soils, the effectiveness of fertilizer application in combination with a differentiated irrigation method is high, in which the depth of soaking and, accordingly, the irrigation rate changes.
Conclusion. The analysis of the data on the economic efficiency of growing seedlings showed that at the selling price of seedlings 170 (grade 1) and 120 (grade 2) rubles per seedling, when growing them against the background of the A3 water regime in combination with top dressing with Izabion and Master, the profitability was the highest and amounted to 155 and 154%. At the same time, the profitability of the control variant was 99%.
Prolonged Grief Disorder in ICD-11 and DSM-5-TR: Factor structure, and psychosocial and loss-related correlates in a sample of widowed persons
Authors: Sękowski Marcin , Ludwikowska-Świeboda Karolina , Prigerson Holly G.
Published: May 2024

Cel pracy

Pierwszym celem badania było określenie, czy objawy PGD, według kryteriów ICD-11 i DSM-5-TR, mają strukturę jednoczynnikową. Po drugie, starano się określić socjodemograficzne i związane ze stratą korelaty nasilenia objawów PGD, zgodnych z ICD-11 i DSM-5-TR.

Metoda

Za pomocą polskich wersji skali Zespołu Żałoby Przedłużonej-13 [Prolonged Grief Disorder-13 (PG-13)] i Inwentarza Żałoby Powikłanej [Inventory of Complicated Grief (ICG)] przebadano osoby, które w przeszłości straciły współmałżonka lub współmałżonkę (N=144) przynajmniej pół roku przed badaniem. W analizach uwzględniono wybrane pozycje PG-13 i ICG, które odnosiły się do kryteriów PGD zawartych w ICD-11 i DSM-5-TR.

Wyniki

Konfirmacyjne analizy czynnikowe potwierdziły jednowymiarową strukturę objawów zaburzenia zawartych w ICD-11 i DSM-5-TR. Krótszy czas od straty oraz śmierć współmałżonka w wypadku były związane z nasileniem objawów PGD, przy uwzględnieniu objawów zaburzenia opisanych w obydwu klasyfikacjach.

Wnioski

PGD jest jednowymiarowym i wewnętrznie spójnym zespołem psychopatologicznym. Szczególnie narażone na rozwinięcie silnych objawów PGD mogą być wdowy lub wdowcy, którzy w nieodległym czasie utracili współmałżonka lub współmałżonkę w wypadku.
Effects of functional treatment of V metatarsal bone fracture in athletes – an evaluation of cases
Authors: Kacprzak Bartłomiej , Krzymińska Klaudia , Siuba Natalia , Hagner-Derengowska Magdalena , Kitschke Ewa , Zukow Walery
Published: May 2024

This study presents the rehabilitation process for the management of six cases of fractures of the fifth metatarsal bone in players of various sports playing at high levels of competition in Poland. The course of treatment was based on an intensive rehabilitation protocol with the need for orthopaedic shoe inserts, with full weight bearing on the limb and under close supervision of a physiotherapist. The effectiveness of rehabilitation was assessed by physical examination, X-ray examination and the numerical pain rating scale - NRS.
This study focuses on the rehabilitation process for managing fractures of the fifth metatarsal bone in high-level athletes in Poland. The treatment involved an intensive rehabilitation protocol with orthopaedic shoe inserts, full weight bearing, and physiotherapist supervision. The effectiveness of rehabilitation was evaluated through physical exams, X-rays, and the numerical pain rating scale.
Introduction
Fractures of the fifth metatarsal bone are common in athletes aged 10-29, especially in football, basketball, and dance. Complications include delayed bone fusion and repeat fractures, emphasizing the importance of quick return to fitness. The involvement of physiotherapists and patient positivity is crucial. The debate among clinicians stems from classification variations and interpretations of 'Jones fractures'.
Diagnostic and Classification Methods
The Lawrence and Bottle classification distinguishes three types of metatarsal fractures: avulsion, Jones, and fatigue fractures. The study presents six cases of conservative treatment for these fractures, showing positive outcomes in returning athletes to competition.
Rehabilitation Procedure
Patients underwent functional treatment with orthopaedic insoles, immediate weight-bearing, and various therapies like Orthokine®, Exogen, hyperbaric chamber sessions, ESWT, and EPTA. Post-workout treatments included Game Ready®, flossing, manual therapy, dry needling, and lymphatic drainage. Patients also engaged in self-managed rehabilitation exercises.
Treatment Results
Radiographic examinations showed progressive healing in all cases, with reduced pain and no edema after two weeks. Patients returned to sports within three weeks, with no complaints after 13 months. The study highlights the success of functional treatment in achieving full recovery without complications.
Conclusion
The study challenges the need for surgical intervention and immobilization in treating fifth metatarsal fractures. Functional treatment led to excellent outcomes and quick return to sports. Literature review supports early mobilization and functional therapy for optimal results. Further research is needed to establish a standard treatment protocol based on evidence-based medicine.
Percepción de la transición primaria-secundaria en el profesorado de ambas etapas.
Authors: Ávila Francés Mercedes , López Fernández Sandra , Paños Martínez Leticia
Published: May 2024

Este artículo aborda la necesidad de ampliar los estudios comparativos de las percepciones del profesorado de educación primaria y secundaria con respecto a la transición entre estas dos etapas educativas. La investigación se lleva a cabo mediante el método de grupos de discusión (un total de 12, con 58 participantes). Se analizan los discursos emitidos por los docentes en ambas etapas con el propósito de identificar similitudes y diferencias en sus perspectivas sobre el proceso de transición. Los resultados destacan que las discusiones se centran en las dificultades y facilidades experimentadas por los estudiantes al cambiar de nivel educativo. Estas cuestiones están influenciadas por tres categorías de factores: aspectos académicos, características del alumnado y aspectos familiares. Se resalta la importancia de la participación tanto del profesorado de primaria como de secundaria para facilitar de manera efectiva el tránsito de los estudiantes entre ambas etapas. El estudio subraya la necesidad de un esfuerzo conjunto para asegurar una transición exitosa de primaria a secundaria. Se destaca la importancia de una coordinación efectiva y menos burocrática entre los diferentes niveles educativos, dando un mayor protagonismo al profesorado y considerando las preocupaciones y necesidades del estudiantado y sus familias.
Percepción de la transición de Educación Primaria a Secundaria: Validación del cuestionario TIRA.
Authors: Vicién Rami Marta , Chocarro de Luis Edurne
Published: May 2024

El paso de Educación Primaria a Educación Secundaria es un momento crítico en la vida del alumnado pues puede verse condicionado si se percibe como un reto o una amenaza, facilitando o dificultando la transición. Esto se agudiza en el alumnado de centros rurales al conllevar un cambio de localidad. Resulta fundamental conocer la situación desde la que parten para poder realizar un acompañamiento adecuado del proceso. El objetivo de este artículo es adaptar al castellano y validar el cuestionario “Items for the scales of the questionnaire: The Impending Transition to Secondary School Perceived as Challenge and Threat” (ITCT - TIRA en castellano), a partir de una valoración interjueces (validez de contenido) y las puntuaciones obtenidas en un estudio piloto (validez de constructo) en una investigación de diseño instrumental. La muestra intencional la integran 209 estudiantes de 6º de Educación Primaria de centros rurales y urbanos. Se realizaron las correspondientes técnicas estadísticas para constatar su validez de constructo, contenido y fiabilidad, obteniendo resultados satisfactorios, cumpliendo así con las características psicométricas. Este resultado confirma que es un instrumento sólido que permite conocer la percepción del alumnado sobre su transición a Educación Secundaria, y facilitar una mejor adaptación a la nueva etapa educativa, reduciendo los factores de riesgo y aumentando los de protección.
Laboratorio de energías renovables: talento joven para hacer prevención en sistemas eléctricos
Authors: Celita Rodríguez David Felipe , Gaitán García Felipe
Published: May 2024

El Laboratorio de Energías Renovables de la Universidad del Rosario es el epicentro de una investigación científica en la que estudiantesde pregrado de diversas áreas tienen un papel protagónico. Su trabajo para la clasificación e identificación inteligente de fallas en sistemas de energía a partir del uso de cámaras infrarrojas ha sido reconocido en escenarios internacionales y vislumbra perspectivas promisorias.
Lilia del Riesgo: “Todo se puede mejorar en este mundo”
Authors: del Riesgo Prendes Lilia , Páez Torres Magda
Published: May 2024

La profesora Lilia del Riesgo es colombiana por adopción, lleva 28 años en el país y afirma que nunca se ha sentido extranjera. Como médica y especialista en bioquímica clínica, se ha dedicado a estudiar temas como los marcadores metabólicos de hipoxia perinatal, en busca de lograr la supervivencia de los recién nacidos. En la Universidad del Rosario, donde ha construido una carrera sólida de casi dos décadas, estudiantes y profesores reconocen con gratitud su valioso aporte académico e investigativo.
Colombia, una democracia con fallas
Authors: Sampayo Andrés Miguel , Basset Yann , Franco Cuervo Ana Beatríz , Botero Cabrera Sandra , Sarasua Suárez Juan Manuel
Published: May 2024

¿Cómo influyen las elecciones en el fortalecimiento de nuestra democracia? En este especial hemos preguntado a diversos investigadores de la Universidad del Rosario sobre aspectos de los procesos electorales de nuestro país que influyen en la calidad y el alcance de la democracia de nuestro país.