bluuebunny/crossref_metadata_2025 huggingface dataset:
Breve historia de la educación en el Perú
Authors: Apaza Romero Abel
Published: October 2019

Esta revisión teórica busca identificar los factores clave de la educación peruana presentes en su calidad educativa frente a los países desarrollados, además se da a conocer la historia de la educación adventista en el Perú y sus aspectos fundamentales. Este estudio se realizó en base a obras realizadas por historiadores, artículos de analistas educativos y a textos de Ellen White. Se concluye que los factores clave para lograr el éxito económico y social de una nación se encuentra en la conexión entre la acción y el conocimiento, entre la investigación y a la formación de profesionales al servicio de las necesidades del Estado, una educación basada en el servicio al prójimo.
Editorial
Authors: Turpo Chaparro Josué E.
Published: October 2019

Editorial
Redes sociales colaborando con docentes de una universidad privada confesional
Authors: Saboya Rios Nemias , Lazo Ortiz Johanna Raquel
Published: October 2019

El propósito del estudio fue determinar el nivel de conocimiento, actitud y práctica de las redes sociales como herramienta académica colaborativa en los docentes de una universidad privada confesional. La investigación fue de tipo básica y de enfoque cuantitativo, con un diseño no experimental, transversal de tipo descriptivo; asimismo el estudio utilizó una muestra conformada por 100 docentes que utilizaban redes sociales como herramienta colaborativa en sus actividades académicas. Los resultados estadísticos demostraron que los docentes tienen mejor actitud al utilizar las redes sociales como herramienta académica colaborativa, siendo esta dimensión la que potencia el uso correcto de las redes sociales, sin embargo, en los conocimientos y práctica los docentes están aún limitados en aprovechar al máximo dichas herramientas durante el proceso de enseñanza- aprendizaje.
Eficacia del Programa Educativo “Donante de vida” para mejorar conocimientos y actitudes hacia la donación de órganos en estudiantes de una universidad privada confesional
Authors: Mamani Limachi Rut Ester , Gamarra Bernal Francis , Chacon Chise Mary Elizabeth
Published: October 2019

La donación de órganos se considera un tema muy importante y emergente en nuestra sociedad; ya que existe un gran número de personas en espera de la donación de un órgano o tejido; y si esto no se resuelve seguirá en aumento la carencia. El objetivo de esta investigación fue determinar la eficacia del programa educativo “Donante de vida” para mejorar conocimientos y actitudes sobre la donación de órganos; el estudio se realizó con estudiantes del primer año de enfermería de una universidad privada confesional. La metodología realizada fue cuantitativa con diseño pre-experimental, aplicando un pre y post-test, utilizando como instrumento un cuestionario de conocimientos con 14 preguntas y 21 proposiciones. La intervención dada a los alumnos de enfermería consta de tres módulos educativos aplicados en 24 sesiones desarrollados en tres meses a una población de 39 estudiantes. Los resultados mostraron efectividad en la aplicación del programa educativo; en el pre-test el 97.4% de los estudiantes presentaron un nivel de conocimiento deficiente y una actitud predominantemente indiferente de 54.4%, después de la intervención los conocimientos incrementaron alcanzando un 82.1% de nivel alto y una actitud de aceptación de 76.9%.
Diseño de un modelo de arquitectura empresarial para publicaciones científicas basado en ADM - TOGAF 9.0
Authors: Saboya Ríos Nemías , Loaiza Jara Omar L. , Lévano Rodríguez Danny
Published: October 2019

El objetivo esta investigación fue proponer el diseño de un modelo de arquitectura empresarial para publicaciones científicas basado en TOGAF 9.0 y modelado en Archimate para la Universidad Peruana Unión La investigación es de tipo tecnológica ya que propone una solución a la necesidad de lograr el posicionamiento a través de un nivel de visibilidad aceptable para publicaciones científicas según líneas de investigación.
Umbrales de la educación Adventista en Chile: Entre el Colegio Adventista de Púa y el Colegio Adventista de Chillán (1906-1922)
Authors: Parada Ulloa Marcos
Published: October 2019

La historia del Colegio Adventista de Púa y del Colegio Adventista de Chillán, se remontan a comienzos del siglo XX en Chile. El primer colegio fue fundado en 1902 con la fundación de la Escuela Adventista de Santiago y en 1906 fue fundado el Colegio Adventista de Púa, dirigido por Carlos Krieghoff, cuyo propósito fue la formación de obreros, evangelización de los indígenas del sector y más tarde ser los iniciadores de la Educación en Chile. En 1922 la Iglesia determinó el traslado del Colegio a la comuna de Chillán, por la conectividad y cercanía con la capital con el objetivo de preparar obreros para la obra adventista.
Diseño y validación de una rúbrica de evaluación de las competencias digitales desde la socioformación
Authors: Salazar-Gómez Elizabeth , Tobón Sergio , Juárez-Hernández Luis G.
Published: October 2019

Debido a la ausencia de investigaciones e instrumentos que exploren y evalúen las competencias digitales tanto en los contextos educativos como comunitarios, se diseñó una rúbrica de evaluación sobre competencias digitales desde el enfoque socioformativo, con base en lo siguiente: 1) revisión documental de la bibliografía de documentos existentes para diagnosticar o evaluar las competencias digitales; 2) construcción del instrumento mediante una estructura tipo rúbrica con la taxonomía socioformativa; 3) revisión y mejora del instrumento por parte de un grupo de 3 expertos; 4) validación de contenido mediante el juicio de expertos en el área; 5) aplicación del instrumento a un grupo piloto compuesto por 44 personas 6) mejora final del instrumento a partir de las sugerencias de los jueces y su evaluación. A partir de la valoración de los jueces expertos, se realizó un análisis de los datos descriptivos y de acuerdo con el coeficiente de la V de Aiken, en los ítem 4, 5, 6, y 7 se obtuvo un puntaje de (V>0.80), no siendo así para los ítem 1, 2, 3, que reflejaron un puntaje menor (V<0.80) a partir de ello y las sugerencias emitidas por los jueces, el instrumento fue modificado en la pertinencia y redacción; en cuanto al nivel de confiabilidad de acuerdo al valor de Alfa de Cronbach se ubico en .845; lo que permite inferir que el instrumento es confiable; En la evaluación cualitativa se obtuvo una mayor frecuencia de los niveles aceptables y alto en pertinencia y redacción, sugiriendo mejoras en las preguntas y no hubo ninguna sugerencia de eliminar ítems.
Estrategias metacognitivas y comprensión lectora en estudiantes universitarios
Authors: Alcas Zapata Noel , Alarcón Diaz Mitchell Alberto , Alarcón Diaz Henry Hugo , Gonzáles LLontop Rosa , Rodríguez Fuentes Antonio
Published: October 2019

La investigación tuvo como objetivo determinar la influencia de las estrategias metacognitivas en la comprensión lectora de estudiantes de una universidad de Lima (Perú). Metodológicamente, se empleó el método hipotético deductivo, con un enfoque cuantitativo y diseño cuasiexperimental. La muestra estuvo conformada por 62 estudiantes pertenecientes a la especialidad de educación. Los resultados descriptivos e inferenciales permitieron demostrar la influencia de las estrategias de metacognitivas en la comprensión lectora de los participantes. En todos los casos analizados se alcanzó el logro previsto evidenciándose así la efectividad de la intervención realizada.
Motivación del logro y resolución de problemas con funciones lineales en una universidad de Surco
Authors: Rostaing Ccapacca Gean Pierre , Bernuy torres Luis Alexis , Borja Villanueva César Andrés , Martínez López Edwin Alberto , Gómez Pérez Isabel Angustias
Published: October 2019

La presente investigación tuvo como objetivo determinar la relación entre la motivación del logro y la resolución de problemas con funciones lineales de los estudiantes de Fundamentos para el Cálculo del turno tarde de la Facultad de Negocios en la Universidad Peruana de Ciencias Aplicadas, 2017. Este estudio se desarrolló dentro de un enfoque cuantitativo, con un método hipotético deductivo y diseño no experimental. La muestra estuvo conformada por 76 estudiantes de Fundamentos para el Cálculo de la Facultad de Negocios de la universidad mencionada. Los resultados permitieron determinar que no existe relación directa y significativa entre la motivación del logro y la resolución de problemas con funciones lineales de los estudiantes encuestados. Esto demostró que la competencia de resolver problemas no depende de la motivación, sino más bien se requiere de conocimiento y habilidades que se manejen.
Sistema de evaluación reder y el plan estratégico de una institución privada confesional
Authors: Villar Guevara Miluska , Toyohama Pocco Gladys
Published: October 2019

Este artículo tiene el objetivo de describir el nivel de cumplimiento del plan estratégico a través del sistema de evaluación REDER de una institución privada confesional, 2017-2019. La metodología utilizada es descriptiva, de diseño no experimental, de corte trasversal, elaborada bajo un enfoque cuantitativo. Al interpretar estadísticamente los resultados se empleó el Software SPSS 24 para análisis descriptivo de frecuencia y de tablas cruzadas. Se aplicó un instrumento de 26 reactivos, dividido en 5 dimensiones, el cual fue administrado a una población de 45 personas de la administración. Se pudo comprobar que el 40% del total de la población de estudio, percibe niveles muy altos y notables de cumplimiento; sin embargo, el 35.6% consideraba el no cumplimiento de estos parámetros. Se concluye que el nivel de cumplimiento del plan estratégico a través del sistema de evaluación REDER, se ubica por debajo de los estándares medios; lo cual se traduce como un punto de mejora en lo que refiere a los patrones de un plan estratégico.
Impacto de una experiencia interdisciplinaria para desarrollar la redacción de cuentos en el aula de historia desde la metodología a+s
Authors: Valdés León Gabriel , Ceballos Ortiz Francisca , Valdebenito Corail Ana , Farías San Martín Mariana
Published: October 2019

El trabajo que aquí se presenta da cuenta de los resultados obtenidos luego de la implementación de un proyecto de Metodología A+S que la Universidad Católica Silva Henríquez llevó a cabo en conjunto con el colegio municipal Los Bosquinos de Maipú. El objetivo principal de este trabajo fue evaluar el impacto de esta experiencia en el desarrollo de la producción de textos narrativos en el aula de historia, geografía y ciencias sociales mediante un trabajo interdisciplinario. Desde la perspectiva didáctica, se desarrolló un módulo didáctico que se sustenta en la escritura por proyectos desde un enfoque procesual. El estudio, de tipo preexperimental con análisis cuantitativo, considera la revisión textual—por parte de tres jueces expertos—de los cuentos realizados por 32 estudiantes de séptimo básico. Los resultados dan cuenta de una mejora considerable en la calidad de los textos narrativos, con énfasis en la competencia discursiva. Por su parte, se destaca el valor que esta experiencia de A+S representó no solo para la institución de educación superior, sino también para el socio comunitario.
Evidencias pedagógicas de gamificación: autoconstrucción y etnoculturalidad de aprendizajes matemáticos
Authors: Holguin Alvarez Jhon , Villa Córdova Gloria María , Tafur Medrano Lizbeth Maricielo , Chávez Álvarez Yasmín Iveth
Published: October 2019

Los estudios de gamificación en educación se han incrementado debido a la dificultad del profesorado para abordar aprendizajes rígidos. En ese sentido, las matemáticas son complejas para la didáctica en escolaridad. Por ello, en el presente estudio se describen dos estudios de corte cuantitativo, con diseño experimental, con el propósito de determinar los efectos de dos tipos de gamificación: a) autoconstructiva y b) etnocultural, a partir de las variables “aprendizaje de la adición y sustracción” y “resolución de problemas” respectivamente. Se incluyeron 80 estudiantes de cuarto grado de primaria en el experimento A (M= 10.3 años; D.E.= 1.54), y en el experimento B se indujo a 36 estudiantes de primer grado (M= 6.4 años; D.E.= 1.36). Para esta investigación se utilizaron dos instrumentos: Prueba de resolución de problemas y Prueba de medición para el aprendizaje de la adición y sustracción. Del experimento A, se concluye que las técnicas etnoculturales desarrollaron la resolución de problemas con efectos significativos en el grupo experimental; los sujetos de dicho experimento desarrollaron problemas de comparación e igualación con mejores indicadores estadísticos. Por su parte, el experimento B concluye que los efectos fueron positivos en el aprendizaje de operaciones de adición y sustracción, con más beneficios para la representación algorítmica y simbólica.
Indicadores de evaluación de citas y referencias en tesis de maestría en educación: una muestra peruana
Authors: M. Hernández Ronald , Arias Chávez Dennis , Flores Sotelo Willian Sebastian , Arévalo Tuesta Jose Antonio , Antón De Los Santos Pedro Juan , Yépez Muñiz León Augusto , Lagos Videla Jessica
Published: October 2019

La presente investigación tuvo por objetivo determinar la calidad de citas y referencias de las tesis de Maestría en Educación de universidades peruanas. Se utilizó la técnica del análisis documental y como instrumento se recurrió a la “Guía de observación” propuesta por Martín y Lafuente (2017), compuesta por cinco indicadores de calidad para la revisión bibliográfica (exhaustividad, utilización crítica de la bibliografía, calidad, relevancia y revisión de investigaciones previas); y nueve para las referencias bibliográficas (actualización, cantidad de referencias, autocitación, idioma, tipología, soporte, referencias completas, exactitud y cumplimiento con una norma o estilo). El análisis se realizó a 562 referencias bibliográficas y 1209 citas extraídas de 14 tesis, digitalizadas y publicadas en el Repositorio Nacional Digital de Perú, durante el año 2017. Se evaluaron tanto los mecanismos de citado, como las referencias bibliográficas. Después del análisis estadístico descriptivo se pudo identificar que el nivel alcanzado para ambas variables fue “suficiente”.
Dependencia del celular, hábitos y actitudes hacia la lectura y su relación con el rendimiento académico
Authors: A. Hilt Jorge
Published: October 2019

El celular (móvil) ha llegado a formar parte de la vida cotidiana de los jóvenes y su uso continúa en expansión, siendo utilizado cada vez a una menor edad. Al mismo tiempo, el uso del celular puede llegar a convertirse en un distractor cuando se lo utiliza en demasía con fines de entretenimiento, especialmente cuando compite con el tiempo que se debe destinar a la lectura y las tareas escolares. Por ello, este estudio trató de establecer si existía una relación entre el uso del celular, los hábitos y actitudes hacia la lectura y suinfluencia en el rendimiento académico en alumnos de nivel medio del Instituto Adventista Mariano Moreno, de la ciudad de Posadas, Misiones, en el ciclo lectivo 2018. El estudio fue de tipo transversal, correlacional y cuantitativo. Para medir el uso del celular se utilizó el Test de Dependencia al Móvil (TDM); las actitudes y hábitos hacia la lectura fueron valoradas con el cuestionario HAL, y el rendimiento académico se obtuvo por medio de la calificación del primer trimestre del ciclo lectivo 2018. La muestra estuvo constituida por 126 estudiantes de primero a quinto año, que representan el 66.67% del alumnado de nivel medio. Se encontró evidencia de que existe una relación negativa entre la dependencia del celular y las otras variables del estudio: (a) hábitos de lectura, (b) actitudes hacia de lectura y (c) rendimiento académico. En lo referente al género, el grupo de alumnas obtuvo mayores puntuaciones en todas las variables del estudio. Aunque lasmujeres hacen un mayor uso del celular y tienen una percepción mayor de dependencia, eso no les impide obtener mejores calificaciones que los varones. Casi la mitad de la muestra utiliza Instagram como red social de preferencia.
Review of the article “ 18F-PSMA-1007 and 18F-fluorocholine PET/CT in prostate cancer progression diagnostics. First comparative experience”
Authors: Muxortova O V.
Published: October 2019

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Clinical and morphological features, immune profile of renal cell tumors with clear cytoplasm
Authors: Osmanov Yu. I. , Kogan E. A. , Severgina L. O. , Rapoport L. M. , Aleksandrov N. S. , Tsarichenko D. G. , Korolyov D. O.
Published: October 2019

In the structure of oncological morbidity, renal cell carcinoma takes the 10th place among malignant neoplasms. The increase in incidence is observed from the age of 35–40 years and reaches a maximum at the age of 65–70 years. In terms of frequency of occurrence, clear cell renal cell carcinoma is ranked first among all kidney tumors. Meanwhile, due to the high heterogeneity of renal cell carcinomas with clear cytoplasm group, significant differential diagnostic difficulties arise in the morphological verification of these tumors. The article presents all nosological forms of kidney tumors with clear cytoplasm and provides a database of already known immunohistochemical markers for each nosological unit.
The role of the renin-angiotensin system in the appearance and progression of renal cell carcinoma: a literature review
Authors: Kogan M. I. , Akhokhov Z. M. , Chernogubova E. A. , Gusev A. A. , Oitova Z. Kh.
Published: October 2019

Renal cell carcinoma (RCC) is one of the most common forms of malignant epithelial tumors of this localization. The development of new approaches to the diagnosis, prognosis and treatment of RCC is an topical issue of molecular medicine. The renin-angiotensin system (RAS) is not only an important component of the central and humoral mechanisms of controlling blood pressure and hydroelectrolytic balance, but also refers to the body systems involved in complex carcinogenesis pathways. Researches on the role of RAS in tumor progression are currently the priority. The data on the role of RAS in the development and progression of malignant tumors in the kidneys are being discussed. In this article, we present an overview of data on the role of RAS in the emergence and development of RCC, an analysis of the molecular mechanisms of development and progression of RCC, the prospects for using indicators of the RAS: angiotensin-converting enzymes (ACE), ACE2 and angiotensin II receptors as markers of diagnosis and monitoring of neoplastic transformation processes in the kidney. The prospects for the use of new, effective anticancer drugs with a targeted effect on definite indicators of the RAS of RCC were analyzed.
New possibilities of combined antiandrogen therapy in patients with metastatic hormone-sensitive prostate cancer
Authors: Alekseev B. Ya.
Published: October 2019

Currently, enzalutamide is the standard of pharmaceutical therapy of metastatic and non-metastatic castration-resistant prostate cancer. However, until recently there was no data on effectiveness and safety of enzalutamide in metastatic hormone-sensitive prostate cancer. Results of 2 large randomized clinical trials ARCHES and ENZAMET showed that early prescription of enzalutamide in combination with standard androgen deprivation therapy allows to significantly increase survival of patient with metastatic hormone-sensitive prostate cancer. The review describes data of these trials and advisability of prescribing enzalutamide in combination with androgen deprivation therapy as 1st line therapy of metastatic hormone-sensitive prostate cancer.
A case of cholestasis caused by Fasciola hepatica diagnosed with endosonography: “Sometimes seeing might not be enough, watching is required”
Authors: ÇAVUŞ Bilger , AKYÜZ Filiz , KAYMAKOĞLU Sabahattin
Published: October 2019

Karaciğerin paraziter hastalıklarından biri olan fasioliazisin en önemli etkeni bir trematod olan Fasciola hepatica’dır. Farklı klinikler ile ortaya çıkabilen Fasciola hepatica’nın tanısında ultrasonografi ve magnetik rezonans görüntüleme ilk tercih edilen görüntüleme yöntemleri olmakla birlikte, bu yöntemlerle yaşanan tanısal zorluklarda endosonografi ile çözüm üretilebilmektedir. Fasciola hepatica’nın neden olduğu kolestaz tablosunda endosonografi ile tanıya ulaştığımız bir olguyu sunduk.
Endoscopic retrograde cholangiopancreatography in super-elderly patients: Is it safe?
Authors: KAHRAMAN Resul , TARIKÇI KILIÇ Ebru
Published: October 2019

Background and Aims: There is no consensus, nor is there sufficient data, on the safety of endoscopic retrograde cholangiopancreatography in super-elderly patients. The demand for endoscopic retrograde cholangiopancreatography is increasing concurrently with the increasing human life expectancy. The aim of this study is, therefore, to assess the outcomes and safety of endoscopic retrograde cholangiopancreatography in super-elderly patients. Materials and Methods: The study sample consisted of 51 patients over 90 years of age who underwent endoscopic retrograde cholangiopancreatography between January 2014 and December 2018. Patients’ demographic characteristics, indications, procedure-, and anesthesia- related adverse events, American Society of Anesthesiologists classification, the presence of comorbidities, and outcomes were analyzed. The Charlson Comorbidity Index was used to analyze comorbidity. A cutoff of Charlson Comorbidity Index ≥2 was used to identify patients on the basis of comorbidities. Results: The mean age of the 51 included participants was 91.86 (Standard Deviation = 2.42) years, and 16 of them were male. Bile duct stones were the most frequent indication (66.7%). Sphincterotomy was performed on 42 participants (82.4%). A stent was used in 17 participants (33.3%). The rate of difficult cannulation was 23.5%. Nine (17.6%) and 12 (24%) participants had minor procedure- and anesthesia-related adverse events, respectively. The mean procedure time was 35.16 (Standard Deviation = 6.65) minutes. Overall success was 86.3%. In-patient mortality was not seen. Conclusion: Therapeutic endoscopic retrograde cholangiopancreatography is a safe and effective treatment for pancreatobiliary disorders in super-elderly patients. Age ≥90 and a Charlson Comorbidity Index ≥2 are independently associated with increased morbidity in patients undergoing endoscopic retrograde cholangiopancreatography, which is successful and well tolerated. Endoscopic retrograde cholangiopancreatography should remain the treatment of choice for super-elderly patients.
Clinical study comparing outcome of post in vitro fertilisation triplet pregnancy reduced to twins versus non reduced in vitro fertilisation triplet pregnancies
Authors: Sharma Sanjay Kumar , Bhatt Reema Kumar , Kapur Anupam , Panda Shakti
Published: October 2019

Background: There has been an upsurge in the number of multiple pregnancies with its attributability to increasing use of artificial reproductive techniques. To study clinical outcome of post IVF triplet pregnancy reduced to twin pregnancies   compared to those without triplet reduction.Methods: Hospital designed comparative study. 31 subjects were studied for comparative study design with triplets obtained after infertility treatment (assisted post-IVF). Out of 31, 15 subjects were expectantly managed who refused reduction while 16 subjects chose reduction to twins. Outcomes like prematurity, complications in neonate, birth weight discordance, neonatal mortality and maternal complications were studied.Results: The fetal (triplet) reduction group was associated with significant (p<0.002) higher neonatal birth weight as compared to non-reduced group. The fetal reduction group had significantly lower incidence of prematurity and neonatal complications like hyperbilirubinemia, respiratory distress syndrome and neonatal sepsis. The maternal complications were also higher in nonreduced in terms of PPROM, gestational hypertension, gestational diabetes mellitus, intrahepatic cholestasis of pregnancy and gestational hypertension.Conclusions: It is indicated that the reduction of triplet to twins is effective considering more complications with non-reduced group and hence reduction improves favorable pregnancy outcomes.
A study of fetomaternal outcome in induction of labour in third trimester oligohydramnios
Authors: Sharma Nalini , Gehlot Hanslata
Published: October 2019

Background: The Induction of labor in oligohydramnios poses a dilemma for obstetrician. Studies are limited with variable results. This study aims at finding whether isolated oligohydramnios is an indication for operative delivery or labor induction followed by vaginal delivery is possible.Methods: A prospective study carried out on females delivered in study duration in Umaid Hospital, Jodhpur, Rajasthan. Outcomes studied were gestational age at delivery, colour of amniotic fluid, FHR tracings, mode of delivery, indication for cesarean section or instrumental delivery, Apgar score at one minute and five minutes, birth weight, admission to Neonatal Intensive Care Unit (NICU), perinatal morbidity and perinatal mortality. Descriptive statistics were applied and data was represented on frequency tables, graphs and diagrams.Results: 40% of subjects had amniotic fluid index (AFI) <5 cm and 60% demonstrated AFI between 5-7 cm. 60% of patients induced delivered vaginally with (38.33%) having AFI <5 cm. Operative delivery was resorted to in 40% of patients. Perinatal outcomes resulted in total 97% of babies discharged in healthy condition.Conclusions: Labor induction is feasible in idiopathic oligohydramnios. Fetal distress is the most feared and predicted outcome with labor induction in oligohydramnios. This study deduced that in majority- reason for c-sections was failed labor induction due the poor Bishop's score, not fetal reasons. We hope by putting at rest apprehensions of obstetrician regarding this notion rate of c-sections could be reduced.
Transcervical resection of endometrium as a conservative management of dysfunctional uterine bleeding in premenopausal patients
Authors: Pote Girish A. , Raut Namita Nandkumar
Published: October 2019

Background: Dysfunctional uterine bleeding (DUB) affects 10% to 15% women of reproductive age group. A prospective observational study was performed to study the efficacy, rate of satisfaction and adverse effects of Transcervical resection of endometrium (TCRE) in the treatment of DUB in premenopausal women.Methods: 30 patients with DUB attending the hospital underwent TCRE and patients were followed up after 6 week, 3 months, 6 months up to 1 year and there bleeding score was calculated. Their response to treatment, complications and satisfaction rate were studied.Results: 43.3% of the women in this study were in the age group of 40-44 years. Post TCRE, 43.33% (n=13) had hypomenorrhea. 33.33% (n=10) had regular cycle, 13.33% (n=4) women had amenorrhea and 10% (n=3) had no response and underwent hysterectomy. 86.66% (n=26) women were satisfied with the treatment whereas 13.33% (n=4) were not satisfied. One patient had uterine perforation and serosal bowel injury due to extended cautery injury. Bleeding reduced considerably and a statistically significant (paired t-test, p-value <0.05) difference was observed in pre and post procedure (6 weeks, 3 months, 6 months and 1 year) bleeding scores.Conclusions: Considering advantages like shorter operative time, uterine conservation and early mobility TCRE is a procedure of choice in patients in whom hysterectomy is either technically difficult or medically contraindicated or in those who are not suitable for long term medical management.
Role of serum copper and lipid profile in cardiovascular diseases patients of Southern Rajasthan
Authors: Dhanak Parul , Sharma Neha , Sharma Ashish
Published: October 2019

Background: It is clear that deficiencies of some trace elements cause marked alterations in lipid and lipoprotein metabolism. The mechanisms of their effects are not completely obvious and inspite of intense research, the role of these microelements need further elucidation. Thus, the objective of this study is to evaluate the correlations of serum concentrations of trace elements including copper with lipid profile parameters of adult men in Southern Rajasthan.Methods: Present study was conducted in Cardiology and Biochemistry Department in GMCH, Udaipur during the year 2019. A total of 150 MI cases/controls were selected. Blood sample was collected by vein puncture using an aseptic technique. The blood was allowed to settle at 37ºC and then centrifuged at 3000 rpm for 15 min. Serum was then separated and stored at -20ºC until analysis.Results: The study cases had significantly higher lipid values than those of controls (p<0.001). In cases the copper levels are higher than the controls. Copper levels were more in males 95.40±18.93 than in females 86.93±14.54 (p<0.05). Lipid levels were higher in urban population related to rural, TC (238.47 V/s 266.59), TG (219.83 V/s 202.40), HDL (64.39 V/s 54.19) and LDL (131.28 V/s 139.48) (p<0.05). Significant negative correlation was seen in study group between serum copper levels and TC (r=-0.288, p<0.05), TG (r =-0.236, p<0.05), HDL (r=-0.946, p<0.05) and VLDL levels (r=0.102, p<0.05). This indicates that as copper level reduces lipids increases.Conclusions:Our findings indicate the possible effect of Cu level in serum lipid profile and this effect may be due to the role of Cu as an antioxidant. The correlations between the serum concentrations of trace elements with lipid profile in physiological concentrations may not be the same as the changes observed during deficiencies of the trace elements as in hyperlipidemic patients
Bone metastasis from malignant phyllodes of the breast
Authors: Dau Daniel Oktavianus , Sudarsa I. Wayan
Published: October 2019

Cystosarcoma phyllodes was described first in 1838 and originally was considered to be a benign tumor. It was not until 1931 that metastasis from a cystosarcoma phyllodes was reported. The incidence of cystosarcoma phyllodes is estimated to be 0.3% to 0.9% of all breast tumors. Sites most commonly affected by metastases are the lungs and bones. We present a case report  29-year old female patient presented with a voluminous breast mass at both of them  which was completely resected. The right side presented of malignant phyllodes and the left side is borderline phyllodes. Six months later, both of her legs became paralyzed and accompanied by swelling over her right upper arm. Biopsy was performed, and the diagnosis was metastatic malignant phyllodes tumor. Histologic review of the breast tumor revealed stromal overgrowth.
Ambulatory blood pressure monitoring in patients with ST- elevation myocardial infarction: one year follow-up study
Authors: Nathani Srikanth
Published: October 2019

Background: The aim of this study was evaluation of nocturnal dipping of blood pressure in ST-elevation myocardial infarction (STEMI) patients and determining the effect of dipping on outcomes at 12 months follow-up.Methods: This was an observational, single-centre, retrospective study that included STEMI patients, performed in a tertiary care hospital in India from November 2016 to October 2017. The primary endpoint of the study was the assessment of outcomes at 12 months.  The patients were divided into two groups on the basis of blood pressure dipping, i.e., patients with positive dipping were considered in group 1 and patients with negative dipping were considered in group 2.Results: Total 43 patients were included in the study. Group 1 consisted of 27 patients and Group 2 consisted of 16 patients. Mean 24 hr systolic blood pressure (SBP) and asleep SBP in Group 1 patients was 128.15±18.05 mmHg and 122.67±18.94 mmHg, respectively. Mean 24 hr diastolic (DBP) and asleep DBP in Group 1 patients was 78.07±10.73 mmHg and 73.41±12.35 mmHg, respectively. In the patients with non-dipping, mean 24 hr SBP and asleep SBP was 130.56±27.32 mmHg and 135.13±29.58 mmHg, respectively. Mean 24 hr DBP and asleep DBP was 76.00±15.40 mmHg and 79.69±17.05 mmHg, respectively. The mean percentage of asleep dipping of SBP was 5.7±6.7% in Group 1 and -4.6±6.82% in Group 2. Similarly, the mean percentage of asleep dipping of DBP was 7.6±9.0% in Group 1 and -6.3±9.1% in Group 2.Conclusions: In view of the results, it can be concluded that ambulatory blood pressure monitoring in patients with STEMI can provide a significant prognostication of the future events.
Effect of maternal age and gestational weight gain on anthropometry of the newborn in semi urban area of Chhattisgarh, India
Authors: Motwani Naresh P. , Jain Ankit , C. Sudhakar
Published: October 2019

Background: Maternal undernutrition is a known to be a major factor contributing to adverse pregnancy outcomes. Gestational weight gain and young maternal age at childbearing years is associated with an increased risk low birth weight babies and infant mortality.Methods: Prospective observational study carried out in the post-natal ward of a tertiary care hospital (CM hospital) in a semi-urban area over a period of 1 year in between March 2018 and March 2019. Total 150 mothers who satisfied the inclusion criteria were enrolled. Age of the mothers was noted and were divided into 5 groups. Last known pre-pregnancy weight was recorded on re-call basis, recorded data on first visit during first month of pregnancy and again they were weighed in the third trimester at the time of admission using standard electronic weight machine. Data collected were entered in Microsoft Excel Work sheet 2018 which was imported to SPSS (version16) for data analysis. Quantitative data has been analysed by Mean, Standard deviation, T test and Karl Pearson correlation.Results: Mean birth weight among young age  mother (<20 years) was 2068 g (95%CI,±223.99) which was significantly lower than mean birth weight of 20-30 year old mother (271.19 g±95%CI, 437.02) and >30 year old mother (2932.78, 95%CI±429.99). With increase in gestational weight gain there was a corresponding increase in mean birth weight and this increase was statistically significant (r=0.435, p=<0.001).Conclusions: Maternal age and gestational weight gain had significant impact on new-born anthropometry. Young age (<20yrs) and decreased gestational weight gain is associated with increased number of low birth weight babies.
Awareness about thalassemia and feasibility of cascade screening in families of thalassemia major patients
Authors: Singh Leeha , Wade Minal , Agrawal Mukesh
Published: October 2019

Background: The main objective of this study is to assess knowledge and attitude of parents & extended relatives of children diagnosed with Thalassemia major and to evaluate feasibility of screening of extended families for thalassemia trait by correlating their willingness to get screened with actual screening.Methods: This was a cross sectional type of descriptive  analytical study, conducted at the thalassemia day care center at a tertiary care teaching hospital in western India among 230 study population using a pre-designed and pre-validated structured questionnaire.Results: We found the overall knowledge score of parents about thalassemia was significantly better than relatives. About 95.83% of parents and only 31.86% of the relatives amongst the study population had adequate knowledge. Majority of study population (84.61% relatives and 100% parents) had positive attitude. The significant contributing factors for knowledge and attitude towards thalassemia were age, marital status, education level, religion and per capita monthly income. 2% relatives agreed to get themselves screened for thalassemia status out of which only 20% got themselves screened.Conclusions: This study has identified key areas which need to be highlighted and emphasized in public awareness campaigns for thalassemia screening in India.
Pulmonary Arterial Hypertension in Pregnancy: Outline of Multidisciplinary Care
Authors: Patel MB  , Kellerhals S  , Horton JP  , Fisher MR  , Krishna I  , Badell ML
Published: October 2019

Pulmonary Arterial Hypertension in pregnancy causes significant maternal and fetal morbidity. There is currently no consensus on recommendations for overall management in pregnancies complicated by pulmonary arterial hypertension. We recommend institutions help build a multidisciplinary team with knowledge about pulmonary arterial hypertension to coordinate care during pregnancy, at delivery and in the postpartum period. The purpose of this article is to highlight some of the challenges in caring for these women, review the literature and help guide care teams by outlining our management process for 5 pregnant patients with WHO Group 1 pulmonary arterial hypertension on epoprostenol.
Pathomorphological manifestations of ischemic involvement of the small intestine in acute occlusion of the mesenteric artery
Authors: Ryabkov Maksim Georgievich , Baleev Michael Sergeevich , Bederina Eugeniy Lvivna , Romanov Ivan Nikolayevich , Shakhov Alexander Vladimirovich , Baleeva Marina Vladimirovna
Published: October 2019

Relevance. Lethality rates (63-95%) among patients with acute intestinal ischemia remain consistently high during the last decades. Despite the high urgency of the problem and numerous works devoted to visualization, early laboratory and instrumental diagnostics of ischemic bowel disease, clinical results have not changed significantly during the last 15-20 years. Pathogenetic mechanisms of various variants of ischemic intestinal lesion and their pathomorphological manifestations should become the basis for the development of surgical tactics and require specification.
The aim is to study pathomorphological manifestations and to clarify on their basis the pathogenetic mechanisms of ischemic involvement of the small intestine in acute occlusion of the mesenteric artery in the experiment.
Materials and methods. An experimental study was performed on 10 laboratory animals - male rats of the Wistar line. Modeling acute mesenteric ischemia was carried out via dressing of the jejunal artery. The ischemic intestine was collected for a stepwise histological study, the morphometry of the layers of the intestinal wall and the prevalence of necrosis.
Results. At the time of the appearance of macroscopic signs of lack of vitality in the central sector of the ischemic intestine, the wall thickness was 47.6% less than normal and in the adjacent peripheral sectors by 40.6%. Thinning of the intestinal wall was due to alteration of the mucosa with a decrease in its share in the total wall thickness from 86 to 82% (p = 0.021) in all sectors. The share of area occupied by necrosis in groups "B" and "C" was not statistically significant (p = 0.872) and amounted to 17.1 [7.3; 64.9]%. The state of the intramural vessels of the intestinal wall had significantly changed in comparison with the intact intestine. Signs of hypoperfusion in the form of sludge in the microvessels of the mucous membrane and the submucosa had been revealed.
Conclusions. Pathomorphological manifestations of ischemic bowel disease in acute occlusive mesenteric ischemia resulted in a decrease in the total thickness of the wall and a change in the ratio of serous-muscular and mucosal-submucosal layers due to a decrease in the proportion of the latter. The severity of necrosis in the central and peripheral parts of the ischemic intestine did not differ.
Risk assessment of ulcerative gastroduodenal bleeding recurrence
Authors: Kolesnikov Dmitriy Leonidovich , Nogteva Vera Evgenevna , Lobanova Alina Vadimovna , Kukosh Mihail Valentinovich
Published: October 2019

Importance of the topic. Bleeding from ulcers of the gastroduodenal zone has been a very urgent problem in surgery for many years. According to a number of authors, the mortality rate is up to 30–40% with their relapse.

Aim of the study is to create a prognostic scale for assessing the risk of relapse of ulcerative gastroduodenal bleeding.

Materials and methods. The work is based on a retrospective analysis of 520 case histories of patients treated at the Berezov City Clinical Hospital No. 7, the basis of the Department of Faculty Surgery of the «Privolzhsky Research Medical University», regarding ulcerative gastroduodenal bleeding during 2010-2017. A comparative analysis of two groups of patients (depending on the occurrence or absence of relapse) is made in the SPSS-2.0 program using a logistic regression method in order to identify a combination of factors influencing the prognosis of the disease.

Results and their discussion. Such factors like the patient's age, the size of the ulcer, the use of combined endoscopic hemostasis, the intensity of bleeding at the time of an emergency EGD, the localization of the ulcer defect have a significant impact on the risk of recurrence. Basing to obtained data, we have developed a scale for assessing the risk of recurrence of ulcerative gastroduodenal bleeding.

Conclusion. The presented method allows to attribute a patient to one or another risk group and it helps to choose the optimal treatment tactics in a short period of time.
Tissue Engineering in Cardiovascular Surgery: Evolution and Contemporary Condition of the Problem
Authors: Soynov Ilya Alexandrovich , Zhuravleva Irina Yurievna , Kulyabin Yuriy Yurievich , Nichay Nataliya Romanova , Timchenko Tatyana Pavlovna , Zubritskiy Alexey Victorovich , Bogachev-Prokophiev Alexander Vladimirovich , Karaskov Alexander Mihaylovich
Published: October 2019

The “ideal” graft for forming outflow ways is a big issue in reconstructive heart valve surgery. For today, this question is a field of interest especially in pediatric cardiac surgery, because the existing prosthesis are exposed to aggressive degenerative processes due to metabolic features, and also do not have the growth potential. Therefore, repetitive graft reimplantation gradually increases risk of surgery and greatly reduce the quality of patient’s life. Tissue engineering is a new perspective approach in surgery of congenital and heart valve diseases, which may help overcome limitations of existing and provide the new opportunities for surgical correction. This review highlights current trends in development of tissue-engineered heart valves and grafts, and existing limitations and potential solutions are discussed.
Nikolai Sergeevich Korotkov - Russian surgeon, pioneer of modern vascular surgery (to the 145th of birthday)
Authors: Andreev Alex Alexeevich , Ostroushko Anton Petrovich
Published: October 2019

N.S. Korotkov was born in 1874 in the city of Kursk. In 1893, after graduating from high school, he entered the medical faculty of Kharkov University, transferred to the medical faculty of Moscow University, which he graduated in 1898 with a degree in medicine with honors. In 1900, N.S. Korotkov became a supernumerary order of a surgical clinic for a term. Further N.S. Korotkov became a doctor of the sanitary unit of the Iberian Red Cross community. For participation in this trip N.S. Korotkov was granted the right to wear the honorary sign of the Red Cross, and in 1902 he was awarded the Order of St. Anne of the III degree. Nikolai Korotkov again works as a supernumerary, since 1903 - a regular intern at the surgical clinic of Professor A.A. Bobrov, then a supernumerary resident at the surgical clinic of Professor SPPedorov of the Imperial Military Medical Academy.In 1904, in the St. George community of the sisters of mercy of the Red Cross Society, a sanitary squad was formed to be sent to the Russian-Japanese war, NS was appointed as the senior physician. Korotkov. Systematically listening to the vessels in the wounded, the young surgeon discovered five regular phases of changes in sounds during compression of the brachial artery with a Riva-Rocci cuff, which later formed the basis of his proposed method for determining blood pressure (Korotkov method). November 8, 1905 N.S. Korotkov for the first time made a historical report “On the issue of blood pressure research methods”. At the end of 1905, he left Petersburg for his parents in the city of Kursk. In 1908, N.S. Korotkov successfully passes the examinations for the degree of doctor of medicine and leaves for Siberia in the mines of the Lena gold mining association for the position of doctor at the Andreevsky hospital. In 1910, N.S. Korotkov defends his doctoral thesis on the topic: "The experience of determining the strength of arterial collaterals." Since 1914, N.S. Korotkov worked as a senior physician at the Petersburg Clinical Hospital. Peter the Great, and with the outbreak of World War I, a surgeon in the Charity House for Wounded Soldiers in Tsarskoe Selo. After the Great October Revolution until the death of N.S. Korotkov served as chief physician at the Mechnikovsky hospital in Petrograd. Nikolai Sergeevich died on March 14, 1920 and was buried in the Theological Cemetery of St. Petersburg. The exact burial place of N.S. Korotkova has not been established, in 2011 a cenotaph was installed on the site of the Military Medical Academy. The Korotkov method was the only official non-invasive blood pressure measurement method approved by WHO in 1935. In honor of N.S. Korotkova is named the street in St. Petersburg, the city hospital of Kursk, the Memorial Society in St. Petersburg.
Photodynamic therapy in the correction of disphagia in patients with esophagus cancer
Authors: Sergei Kozlov Vasilievich , Kaganov Oleg Igorevich , Moriatov Alexandr Alexandrovich , Meshkova Maria Alexandrovna
Published: October 2019

Relevance. In spite of successes in diagnostic and treatment of cancer, malignant neoplasm of the esophagus remain an acute problem. Cancer of the esophagus and gastroesophageal zone are the most prognostically unfavorable disease of the digestive tract. At the time of treatment, more than 70% of patients with esophageal cancer suffer from grade II – IV dysphagia, which significantly impairs the functional state and quality of life. Dysphagia indicates that 70% of the lumen of the esophagus is filled with a tumor.Purpose. Improve the results of treatment of patients with esophageal cancer with dysphagia through the use of fluorescent diagnostics and photodynamic therapy. Materials and methods. The study group included 49 patients with a diagnosis of esophageal cancer, where the disease was complicated by tumor obturation. Patients received photodynamic therapy with the use of the photogem sensitizer of hemato-porphyrin series. The comparison group included 32 patients complicated by dysphagia who received a course of radiation therapy. All patients underwent treatment and further examination at the Samara Regional Clinical Oncology Center from 2015 to 2017.Results and their discussion: In study group in 13 (26.5%) cases an increase in the lumen of the esophagus to 1 sm or more was recorded. In this case, the patient could take any food. A decrease in the degree of dysphagia was observed in 21 cases (42.8%). In 6 cases (12.2%), the tumor visually decreased in volume, but clinical improvement wasn’t observed. Positive functional results with decrease in dysphagia grade were obtained in 72 % of patients. Complete dysphagia resolution was achieved in 28 % of cases. The median survival rate was 24 weeks. In comparison group full restoration of patency was obtained in 8 cases (25%), partial - in 10 (28%). No effect was observed in 14 (43.7%) cases. Only in 8 (25%) cases an increase in the lumen of the esophagus to 1 sm or more was recorded. The median survival rate was 21 weeks.Conclusion. The result suggests a significant efficacy of photodynamic therapy compared with the results of radiation therapy. The use of photodynamic therapy allows to achieve a high degree of functional rehabilitation in patients with esophageal cancer complicated by dysphagia in the absence of serious complications.