bluuebunny/crossref_metadata_2025 huggingface dataset:
Discounts as a Barrier to Change in Our Food Systems
Authors: Jack Lisa
Published: March 2023

Despite the wealth of discussion and ideas on how food systems might change, and all the plans and schemes created to provide solutions to unsustainable food systems, very few researchers have examined the accounting practices that define socio-economic relationships around food. In this article, I show that the imperative for each entity in food supply networks to obtain a discount on costs involved in food supply to survive on very thin margins, inhibits large-scale change. The approach here is introductory, providing an explanation of the accounting issues involved for a non-accounting audience, and an illustrative case study is used to show the embeddedness of always ‘getting a discount’. The case study is drawn from interview data with those involved in intermediary companies and in alternative food distribution in Canada and the USA. The difficulties faced by organisations distributing food on a more local level and the lack of lasting and widespread change despite their endeavours, is shown to linked to the inevitability that they too need to ‘get discounts’ to survive. This interdisciplinary study is important to provide context for sociological thinkers and activists seeking to understand the barriers to change in food behaviours and food strategies.
Explaining Regularities or Individual Outcomes: Chance and the Limits of Social Science
Authors: Glaesser Judith
Published: March 2023

Can we explain individual outcomes by referring to patterns observed in populations? Social scientists generally assume that we can, at least to a certain degree, and they study populations partly with that goal in mind. However, while patterns can be observed on the population level, which suggest that, on average, certain segments of the population are more likely to experience some outcome, it is impossible, on the individual level, to predict who will actually experience the outcome, even if the individual’s relevant characteristics are known. Thus, an interesting tension emerges: on the one hand, individual action and experience produces population-level patterns, while on the other hand, individual experience appears to be ‘inherently underdetermined’ and partly or largely due to luck or chance. Accordingly, this article considers the relationship between regularities and individual outcomes and to what extent it is desirable to construct models which can explain all the variance in outcomes, and the roles of true chance and what one might call ‘as-if’ chance in this. An empirical demonstration based on ALLBUS data explores these issues further. It uses the example of the graduate premium to discuss that, while there is a pattern where, on average, graduates earn more than non-graduates, there is a certain degree of individual-level deviation from this pattern (even after taking account of other relevant factors) which is partly due to chance. Patterns identified in data can provide the upper and lower bounds within which chance plays its part. The article closes with a discussion of implications for research and policy, and for the understanding of research findings by the general public.
Are lay abstracts published in Autism readable enough for the general public? A short report
Authors: Yi Lan , Yang Xiaohu
Published: March 2023

Lay abstracts are brief descriptions or summaries of research that are targeted at a general audience. They are held as an important means for the research community to provide greater transparency to the general public and to increase visibility of the pertinent research. This study aims to examine the extent to which lay abstracts published in the journal Autism are comprehensible to a lay audience in terms of readability measures. Results showed that lay abstracts published in Autism were more readable than their corresponding abstracts but were less readable than plain English texts (e.g. news reports). To our knowledge, this is probably the first comparative study on the readability of lay abstracts. Possible explanations for and implications of these findings were offered.

Lay abstract

Research papers are sometimes hard to follow. Lay abstracts give a short account of research papers. However, it is unclear whether lay abstracts are readable to the lay people. This study examined the readability of 570 abstracts and lay abstracts published between 2020 and 2022 in the journal Autism. We found that that lay abstracts are easier to read than abstracts but are harder to read than news reports. The findings suggest that lay abstracts, on average, are hard to read for the lay people. We propose that the journal and its authors may invite reviewers from outside the research community to test whether a lay abstract is readable.
Associations between COVID-19-related changes in the psychosocial work environment and mental health
Authors: Blomqvist Sandra , Virtanen Marianna , Westerlund Hugo , Magnusson Hanson Linda L.
Published: March 2023

Background:

Individuals’ lives have been substantially affected by the COVID-19 pandemic. We aimed to describe changes in psychosocial work environment and mental health and to investigate associations between job insecurity and mental ill-health in relation to changes in other psychosocial work factors, loneliness and financial worries.

Methods:

A sub-sample of individuals from the eighth Swedish Longitudinal Occupational Survey of Health answered a web-based survey in early 2021 about current and pandemic-related changes in health, health behaviours, work and private life. We investigated participants working before the pandemic ( N=1231) in relation to standardised measures on depression, anxiety and loneliness, together with psychosocial work factors, in descriptive and logistic regression analyses.

Results:

While 9% reached the clinical threshold for depression and 6% for anxiety, more than a third felt more worried, lonelier or in a low mood since the start of the pandemic. Two per cent had been dismissed from their jobs, but 16% experienced workplace downsizings. Conditioning on socio-demographic factors and prior mental-health problems, the 8% experiencing reduced job security during the pandemic had a higher risk of anxiety, but not of depression, compared to employees with unaltered or increased job security. Loneliness and other psychosocial work factors explained more of the association than objective measures of job insecurity and financial worries.

Conclusions:

Reduced job security during the COVID-19 pandemic seems to have increased the risk of anxiety among individuals with a strong labour market attachment, primarily via loneliness and other psychosocial work factors. This illustrates the potentially far-reaching effects of the pandemic on mental health in the working population.
The relationship between online communication and adolescents’ mental health: Long-term evaluation between genders
Authors: Birgisson Ottar , Hysing Mari , Eriksen Hege R. , Johannsson Erlingur , Gestsdottir Sunna
Published: March 2023

Aims:

In a relatively short time, online communication has become an important part of adolescents’ lives, and concerns have been raised about its potential effects on mental health. The first aim was to compare mental health status and online communication in 15-year-old Icelanders born in 1988 and in 1994. The second aim was to assess whether the relationship between online communication and mental health has changed among 15-year-old Icelanders from 2003 to 2015 across genders.

Methods:

Analysis used data from self-reports from 2003 ( N=385, 51% males) and 2015 ( N=302, 42% males). Mental health was assessed with subscales of Symptom Checklist 90 and online communications with self-reports. To evaluate the difference in anxiety and depression, a factorial analysis of variance was conducted between gender and years. Multigroup structural equation modelling was used to assess the change in the relationship between years.

Results:

Symptoms of anxiety and depression remained unchanged for males. Symptoms of depression increased for females, while anxiety was stable between 2003 and 2015. In 2003, there was no relationship between online communication and mental health. However, in 2015, an association was found for females.

Conclusions:

Depression is getting worse for adolescent females, and an association between time spent online communicating and mental health emerged for them in 2015, which did not exist in 2003. These findings add to the possibility that online communication is harmful for mental health, but more detailed studies are still needed.
Prescreening in oncology trials using medical records. Natural language processing applied on lung cancer multidisciplinary team meeting reports
Authors: Ansoborlo Marie , Gaborit Christophe , Grammatico-Guillon Leslie , Cuggia Marc , Bouzille Guillaume
Published: March 2023

Defining profiles of patients that could benefit from relevant anti-cancer treatments is essential. An increasing number of specific criteria are necessary to be eligible to specific anti-cancer therapies. This study aimed to develop an automated algorithm able to detect patient and tumor characteristics to reduce the time-consuming prescreening for trial inclusions without delay. Hence, 640 anonymized multidisciplinary team meetings (MTM) reports concerning lung cancers from one French teaching hospital data warehouse between 2018 and 2020 were annotated. To automate the extraction of eight major eligibility criteria, corresponding to 52 classes, regular expressions were implemented. The RegEx’s evaluation gave a F1-score of 93% in average, a positive predictive value (precision) of 98% and sensitivity (recall) of 92%. However, in MTM, fill rates variabilities among patient and tumor information remained important (from 31% to 100%). Genetic mutations and rearrangement test results were the least reported characteristics and also the hardest to automatically extract. To ease prescreening in clinical trials, the PreScIOUs study demonstrated the additional value of rule based and machine learning based methods applied on lung cancer MTM reports.
Numerical design and optimization of metamaterials for underwater sound absorption at various hydrostatic pressures
Authors: Fu Yifeng , Wang Huming , Cao Pan
Published: March 2023

Underwater sound absorption materials with a stable performance at various hydrostatic pressures are important for marine applications. However, most studies about underwater sound absorption materials only focused on the performance at atmospheric hydrostatic pressure, while ignoring the influence of various hydrostatic pressures. Aiming to improve the underwater sound absorption stability of a metamaterial at various hydrostatic pressures, different structures and a Nelder–Mead algorithm with an acoustic-structure fully coupled finite element method (FEM) model are developed to optimize the structure of the metamaterial at various hydrostatic pressures. In this numerical modeling, the metamaterial is a PDMS matrix embedded with periodic cylinders. Firstly, the effect of hydrostatic pressure on the metamaterial is evaluated in the frequency range [0, 8 kHz]. Secondly, different cases are designed to improve the underwater sound absorption stability at various hydrostatic pressures, including different cylinder radii, different distances between the air cylinder and the steel backing, and different void shapes. Then two layers of air and/or steel cylinders are introduced to further improve sound absorption performance under various hydrostatic pressures. The results indicate that PDMS with two layers of air cylinders have the optimal sound absorption stability performance under various hydrostatic pressures, which can be attributed to the top layer of air cylinders absorbing the main deformation. Lastly, the optimization algorithm significantly improves the sound absorption performance of the metamaterials at various hydrostatic pressures. This combination of an optimistic algorithm and FEM can guide the design of underwater sound absorption metamaterials at various hydrostatic pressures.
Introduction
Authors: Kienpointner Manfred
Published: March 2023

This special issue represents some of the recent developments within argumentation studies. The following overview provides some historical context for the five papers which constitute this special issue. The Aristotelian roots of modern argumentation studies are briefly presented, as well as some further developments within Greek and Roman rhetoric. Furthermore, the most important developments in argumentation studies during the last few decades are sketched. Several modern approaches to argumentation theory are introduced, among them Perelman/Olbrechts-Tyteca’s New Rhetoric, Toulmin’s model of argumentation, formal dialectics, fallacy theory, informal logic, the Argumentum Model and Pragma-Dialectics. Finally, the thematic focus of the five papers is described.
Who is who in fact-checked conspiracy theories? Disseminators, sources, and the struggle for authority in polarized environments
Authors: Marques Francisco Paulo Jamil , Ferracioli Paulo , Comel Naiza , Kniess Andressa Butture
Published: March 2023

Despite the growing scholarship concerning mis- and disinformation, research has yet to assess how journalism tackles conspiracy theories in settings where news organizations and media professionals have their authority questioned. Against this background, our article poses two research questions: RQ1) Who are the actors mainstream fact-checkers cover when addressing conspiracy theories? RQ2) To what extent does the focus on such actors delegitimize those who challenge news organizations or compete with them for the audience? Using content analysis as our key methodological strategy, we consider 197 fact-checks published between 2018 and 2021 by the Projeto Comprova, a Brazilian initiative currently comprising professionals from 41 media organizations. We found that the most discussed topics were those mobilizing polarized groups, namely, the Covid-19 pandemic and election fraud allegations. The then-President Bolsonaro and his supporters were often cited as disseminators of such plots. In turn, Facebook is pointed out as a thriving environment for the circulation of conspiratorial narratives. The results also reveal the prominence of mainstream news outlets as sources to ground the “factual” information sustained in the fact-checks. More interestingly, our data suggest that fact-checkers have favored specific news values when addressing conspiracy theories. To strengthen our investigation, we use interviews with four professionals contributing to the Comprova to illustrate how the project has brought together rival companies interested in delegitimizing “alternative” sources of information.
Strengthening the relationships between different parties: Boundary-spanning competencies in hospital social work
Authors: Mannsåker Ida Krag-Rønne , Vågan André
Published: March 2023

Hospital social workers advocate, facilitate and communicate with patients, families, healthcare professionals, and communities. These activities, in which hospital social workers relate to different parties and aim to strengthen relationships between them, have been referred to in the literature as boundary spanning. This study explores hospital social workers’ boundary-spanning competencies associated with their boundary-spanning activities. The data were from in-depth interviews with 19 hospital social workers in Norway. A hybrid analysis was performed, combining initial inductive coding of themes with subsequent deductive coding based upon a conceptual framework. Four themes emerged: (1) Being informed, (2) Content knowledge, (3) Tailoring and (4) Self-knowledge. The findings contribute to specifying central boundary-spanning competencies. Implications of the study for social work practice and education are provided, along with recommendations for further research.
Endovascular Closure of an Acquired Vascular Fistula, an Uncommon Complication of a Tunneled Hemodialysis Catheter: A Case Report
Authors: Soledispa-Suarez Carlos Ivan , Alberca-Bonilla Stephanie Susana
Published: March 2023

Purpose:

The objective of this case is to report an endovascular occlusion of an acquired vascular fistula using an Amplatzer Vascular Plug II. Also, it is to review the available literature on risk factors, pathophysiology, and related management strategies about complications of the tunneled central venous catheter (TCVC).

Case Report:

The case was a 40-year-old man with a chronic kidney disease (CKD) on dialysis and with a history of several previous TCVC placements, along with recurrent infections. The last TCVC developed a fistula between the superior vena cava and the right pulmonary artery, shown by computed tomography (CT). We decided to remove a long-term TCVC and occluded the fistula applying an endovascular embolic device, an Amplatzer Vascular Plug II, subsequently. The patient was given parenteral treatment during 10 days of hospitalization. Over 9 months of follow-up, the device was appropriately positioned and did not obstruct the vascular flow.

Conclusion:

Tunneled central venous catheters are frequently used for hemodialysis in patients in the last stage of CKD who do not have an arteriovenous fistula. Occasionally, delayed complications such as adherence or catheter migration occur. This case illustrates an endovascular treatment with excellent results and low risk of morbidity and mortality.

Clinical Impact:

The purpose of this work is to present an endovascular occlusion by means of an Amplatzer® Vascular Plug II in a residual fistula. The endovascular way is decided in situations, for instance, once the cardiothoracic surgeons argue that the patient is not in general conditions to tolerate surgery, the surgical procedure would be complex, or, in a surgical approach with a difficult-to-resolve hemorrhage. We explain the technique and the materials we used for an excellent result and a low risk of complications. This case is intended to serve as an aid in the treatment of similar events.
Endovascular Management of Combined Symptomatic Spontaneous Isolated Renal and Celiac Arterial Dissection: A Case Report
Authors: El Kashef Omar , Noureldin Mohammed
Published: March 2023

Purpose:

To report a unique entity and its management that occurred at our facility: combined spontaneous isolated renal and celiac arterial dissection (SIRCAD) with resultant renal and gastrointestinal symptoms.

Case Report:

A 50-year-old man with no past medical history presented with a 4 day history of nausea, intermittent stabbing epigastric pain, right flank pain, and uncontrolled hypertension. After full physical examination and imaging studies, the diagnosis of SIRCAD was established and confirmed. Selective right renal artery catheterization revealed dissection limited to the main trunk, and after careful selective hand-injection and successful cannulation of the distal renal artery branches through the true lumen assisted by intravascular ultrasound, a balloon expandable covered stent (6 mm in diameter and 60 mm in length) was deployed in the main renal artery. The same steps were performed for management of the celiac artery dissection. The patient was treated with clopidogrel 75 mg for 6 weeks and lifetime aspirin. A week after the procedure, his symptoms completely resolved.

Conclusion:

The pathology of SIRCAD in the absence of other vascular dissections is extremely rare, which speaks for the necessity of reporting this case and highlights the great role of evolving imaging modalities in the diagnosis and management of such cases.

Clinical Impact

Symptomatic combined spontaneous isolated renal and celiac arterial dissection (SIRCAD) remain rare despite the increased frequency of reports on asymptomatic dissections. The etiology of SIRCAD is not precisely defined. Moreover, treatment of SIRCAD remains controversial with only a few cases of percutaneous interventional treatment are reported in the literature.
The GEUS Palynology, Nannofossil, and Microfossil Arctic Slide Collection
Authors: Nøhr-Hansen Henrik , Piasecki Stefan , Śliwińska Kasia K. , Lindström Sofie , Sheldon Emma , Dybkjær Karen , Ryge Annette , Olsen Charlotte , Alsen Peter , Boserup John
Published: March 2023

Since 1976 more than 25,000 Arctic sediment samples have been processed for their palynological, nannofossil, or microfossil content at the Geological Survey of Greenland (GGU) and the Geological Survey of Denmark (DGU); both institutes are now merged into the Geological Survey of Denmark and Greenland (GEUS). The samples represent nearly all ages from the Neoproterozoic to the Neogene, though dominated by the Mesozoic. A large proportion of the samples were processed for palynomorphs. Up to ten slides have been produced for each palynological sample and usually one slide is produced for each nannofossil and microfossil sample, making the GEUS collection one of the largest Arctic slide collections with more than 200,000 slides. All type specimens and some specimens illustrated in publications listed here have been assigned MGUH numbers ( Museum Geologica Universitas Hafniensis) and are housed in the type collection of the Geological Museum of the University of Copenhagen, now part of the Natural History Museum of Denmark.
Time in Nature: A Prescription for the Prevention or Management of Hypertension
Authors: Bauer Angel , White Nicole D.
Published: March 2023

Growing evidence suggests time in nature may positively influence a broad range of health outcomes including blood pressure. The mechanism(s) by which nature exerts this influence is not fully understood, but it has been proposed that nature or natural environments promote health due to opportunities for physical activity and stress reduction. Experimental and observational studies suggest that time in forests or other green spaces is associated with reduced blood pressure, lower prevalence of hypertension, and reduced odds of using antihypertensive medications. Therefore, prescribing time in nature for patients at risk or diagnosed with hypertension may have substantial benefits.
Review: Research on product surface quality inspection technology based on 3D point cloud
Authors: Huo Lintao , Liu Ying , Yang Yutu , Zhuang Zilong , Sun Mengmeng
Published: March 2023

In recent years, machine vision has played an important role in product surface quality detection. The promotion and use of this technology have largely avoided the subjectivity caused by human detection and improved detection efficiency and accuracy. Different from the image data commonly used in machine vision, point cloud can describe the spatial structure of an object, provide more information than image data, and have the ability to expand the data to build multi-dimensional data models. Due to the strong anti-interference ability of point cloud sensors and the high accuracy of three-dimensional positioning information point cloud, nondestructive testing technology based on point cloud has received more and more attention. This paper summarizes the research progress of product surface quality detection methods based on 3D point cloud in recent years. According to different data processing methods, the detection research is divided into five categories: based on point cloud contour, based on local geometric feature, based on template matching, based on multimodal point cloud, and based on deep learning. The five methods are reviewed and summarized respectively. Finally, the key problems of each detection method and the future trend of product surface quality detection technology based on 3D point cloud are discussed.
Charismatic rhetoric, perceptions of charisma and narcissism, and voting behavior: Leadership under crisis
Authors: Barreto Tais S , Williams Ethlyn A , Sims Randi L , Pillai Rajnandini , McCombs Kate , Lowe Kevin B
Published: March 2023

Although research recognizes the influence of charismatic leadership and rhetoric, their practice in differing contexts and the moderating role of narcissism is understudied. Using a mixed-methods approach, we explore the effects of crises on the way a narcissistic leader employs charismatic rhetoric, and the way charismatic leadership is viewed by followers as they select leaders during a national crisis. In Study 1, we investigate former President Donald Trump’s response to threats to his social power during times of crisis. Content analysis of Trump’s speeches revealed that he used less charismatic rhetoric overall and more self-focused rhetoric during crisis periods, an unexpected outcome given existing findings in the literature. In Study 2, we explore followers’ responses to Trump’s perceived charisma. Three matched waves of data examined responses about perceived charisma, importance placed on the COVID-19 pandemic crisis, and leader choice. Findings from Study 2 suggest that crisis influenced perceptions of charisma and voting behavior, with leader narcissism playing a moderating role. Overall, our findings have implications for understanding the role of crisis in charismatic rhetoric and how narcissism and leader charisma influence followers’ voting behavior.
Constructing the ‘us’ and ‘them’ dichotomy through the notion of responsibility: An integrated framework
Authors: Zhao Xin
Published: March 2023

Based on the methodological approach to responsibility-related discourses in critical discourse studies and the theoretical understanding of the notion of responsibility in international relations and political studies, this paper proposes an integrated theoretical and methodological framework for responsibility-related discourses in the political realm. It evidences the applicability of the proposed framework in discourses of China-US trade conflicts constructed by China’s state-run news media in both traditional and social media platforms in 2019 and 2020. The proposed framework extends the explanatory power of the notion of responsibility in constructing the ‘us’ and ‘them’ dichotomy.
A novel use and dramatic efficacy of ofatumumab for the treatment of anti-N-methyl-D-aspartate receptor encephalitis: a report of two cases
Authors: Gong Xue , Zhou Dong , Hong Zhen
Published: March 2023

Ofatumumab (OFA), a subcutaneous anti-CD20 monoclonal antibody, selectively depletes B-cells. The purpose of this study was to report the therapeutic effect and safety of OFA in two refractory anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis cases which were nonresponsive to first-line immunotherapies. Two severely affected anti-NMDAR encephalitis patients (mRS score: 5) with resistance to standard immunotherapies (corticosteroids, IV immunoglobulins) were treated with OFA (3 subcutaneous injections of 20 mg on days 1, 7, 14). The patients’ guardians declined plasma exchange (PE) and RTX. The clinical outcome of the patients was followed up for 6 months after the administration of OFA. Treatment with OFA led to rapid clinical improvement accompanied by the enhancement of neuropsychiatric function, disappearance of brain MRI lesions, and decline in partial NMDAR antibody titer. The CD20-positive B-cells were completely depleted in both patients. Moreover, the therapy was well tolerated with no adverse effects. The patients were discharged without clinical deficits and with significantly improved cognition. OFA appeared to be highly effective in the two presented cases despite the limited first-line therapy without PE, which suggests good potential for the application of OFA in this field. However, the lingering effects of previously administered corticosteroids and IV immunoglobulins cannot be excluded.
PGC1α: an emerging therapeutic target for chemotherapy-induced peripheral neuropathy
Authors: Zhai Mingzhu , Hu Haibei , Zheng Yi , Wu Benqing , Sun Wuping
Published: March 2023

Chemotherapy-induced peripheral neuropathy (CIPN)-mediated paresthesias are a common complication in cancer patients undergoing chemotherapy. There are currently no treatments available to prevent or reverse CIPN. Therefore, new therapeutic targets are urgently needed to develop more effective analgesics. However, the pathogenesis of CIPN remains unclear, and the prevention and treatment strategies of CIPN are still unresolved issues in medicine. More and more studies have demonstrated that mitochondrial dysfunction has become a major factor in promoting the development and maintenance of CIPN, and peroxisome proliferator-activated receptor gamma (PPARγ) coactivator 1α (PGC1α) plays a significant role in maintaining the mitochondrial function, protecting peripheral nerves, and alleviating CIPN. In this review, we highlight the core role of PGC1α in regulating oxidative stress and maintaining normal mitochondrial function and summarize recent advances in its therapeutic effects and mechanisms in CIPN and other forms of peripheral neuropathy. Emerging studies suggest that PGC1α activation may positively impact CIPN mitigation by modulating oxidative stress, mitochondrial dysfunction, and inflammation. Therefore, novel therapeutic strategies targeting PGC1α could be a potential therapeutic target in CIPN.
Evaluation of Different Patterns of Zygomaticoorbital Complex Fractures
Authors: Sakkas Andreas , Weiß Christel , Pietzka Sebastian , Wilde Frank , Thiele Oliver Christian , Mischkowski Robert Andreas
Published: March 2023

Study Design

Very few studies exist regarding the fracture pattern variability of the zygomaticoorbital (ZMO) complex. The retrospective evaluation of a large series of surgically treated unilateral ZMO fractures would in certain circumstances help intraoperative predictability and define sensitive indicators for open reduction and internal fixation.

Objective

The aim of this study was to investigate the different fracture patterns after ZMO complex injury regarding the 5 anatomic sutures of the zygoma as well as the concomitance of the paranasal buttress and maxillary sinus wall fracture.

Methods

The medical records of all patients with unilateral ZMO fractures who underwent surgical intervention in a single trauma center department between April 2015 and June 2020 were retrospectively reviewed. Demographic and anamnesis data, radiologic findings, and surgical reports were evaluated. According to the preoperative radiologic evaluation, ZMO fractures were classified as unisutural, bisutural, trisutural, tetrasutural, and complete based on the number of zygomatic sutures. The prevalence of various fracture patterns was analyzed. The impact of patient’s age and trauma etiology on the fracture pattern was evaluated using descriptive statistical analysis.

Results

The study included 492 patients with unilateral ZMO fractures, with a mean age of 49.93 years (SD = 20.66) and a male:female ratio of 2.23:1. The most affected age group was 19–44 years (41.67%) and tripping falls were the most common etiology (27.24%). Trisutural (57.32%) and unisutural fractures (23.17%) were the most common, followed by tetrasutural (8.94%), bisutural (8.54%), and complete fractures (2.03%). A trisutural fracture involving the zygomaticomaxillary suture, the infraorbital rim, and the zygomaticosphenoidal suture was the most common fracture pattern (52.03%). Most fractures were observed in the zygomaticosphenoidal suture (86.99%), followed by the infraorbital rim (74.59%) and the zygomaticomaxillary suture (68.29%). Fractures of the maxillary sinus wall and the paranasal buttress co-existed in 9.55% and 31.30% of all cases, respectively. No correlation was detected between age and fracture pattern ( P = .4111). Tripping falls and bicycle accidents significantly influenced the fracture pattern ( P < .0001).

Conclusions

According to the results, knowledge of the fracture pattern variability of the ZMO complex could in certain circumstances designate CT or CBCT as mandatory before operating on ZMO fractures. Consequently, unnecessary incisions could be avoided. The high concomitance of paranasal buttress fracture also suggests its intraoperative surgical exploration. Further studies should correlate the clinical findings with indication for surgery and postoperative outcome for the different fracture patterns described.
Second to none: rationale, timing, and clinical management of clozapine use in schizophrenia
Authors: Qubad Mishal , Bittner Robert A.
Published: March 2023

Despite its enduring relevance as the single most effective and important evidence-based treatment for schizophrenia, underutilization of clozapine remains considerable. To a substantial degree, this is attributable to a reluctance of psychiatrists to offer clozapine due to its relatively large side-effect burden and the complexity of its use. This underscores the necessity for continued education regarding both the vital nature and the intricacies of clozapine treatment. This narrative review summarizes all clinically relevant areas of evidence, which support clozapine’s wide-ranging superior efficacy – for treatment-resistant schizophrenia (TRS) and beyond – and make its safe use eminently feasible. Converging evidence indicates that TRS constitutes a distinct albeit heterogeneous subgroup of schizophrenias primarily responsive to clozapine. Most importantly, the predominantly early onset of treatment resistance and the considerable decline in response rates associated with its delayed initiation make clozapine an essential treatment option throughout the course of illness, beginning with the first psychotic episode. To maximize patients’ benefits, systematic early recognition efforts based on stringent use of TRS criteria, a timely offer of clozapine, thorough side-effect screening and management as well as consistent use of therapeutic drug monitoring and established augmentation strategies for suboptimal responders are crucial. To minimize permanent all-cause discontinuation, re-challenges after neutropenia or myocarditis should be considered. Owing to clozapine’s unique efficacy, comorbid conditions including substance use and most somatic disorders should not dissuade but rather encourage clinicians to consider clozapine. Moreover, treatment decisions need to be informed by the late onset of clozapine’s full effects, which for reduced suicidality and mortality rates may not even be readily apparent. Overall, the singular extent of its efficacy combined with the high level of patient satisfaction continues to distinguish clozapine from all other available antipsychotics.
Evidence and experiment: Curating contexts of Anthropocene geology
Authors: Rosol Christoph , Schäfer Georg N , Turner Simon D , Waters Colin N , Head Martin J , Zalasiewicz Jan , Rossée Carlina , Renn Jürgen , Klingan Katrin , Scherer Bernd M
Published: March 2023

Together with research teams from around the world, the Anthropocene Working Group (AWG) has been meticulously quantifying and scrutinizing the global stratigraphic imprint of human activities, the results of which are gathered in this thematic collection of papers in The Anthropocene Review. How can such empirical research, which so impressively articulates the end of a relatively stable Earth System in the mid-20th century, inform our ways of understanding and responding to the planetary crisis that the geological samples quietly represent? In this afterword to the collection we report and reflect on the joint undertaking of the AWG, Haus der Kulturen der Welt and the Max Planck Institute for the History of Science to bring geoscientific evidence, cultural experimentation and historical contextualization together in a shared public framework.
Risk Ahead: Actigraphy-Based Early-Warning Signals of Increases in Depressive Symptoms During Antidepressant Discontinuation
Authors: Kunkels Yoram K. , Smit Arnout C. , Minaeva Olga , Snippe Evelien , George Sandip V. , van Roon Arie M. , Wichers Marieke , Riese Harriëtte
Published: March 2023

Antidepressant discontinuation increases the risk of experiencing depressive symptoms. In a repeated single-subject design, we tested whether transitions in depression were preceded by increases in actigraphy-based critical-slowing-down-based early-warning signals (EWSs; variance, kurtosis, autocorrelation), circadian-rhythm-based indicators, and decreases in mean activity levels. Four months of data from 16 individuals with a transition in depression and nine without a transition in depression were analyzed using a moving-window method. As expected, more participants with a transition showed at least one EWS (50% true positives; 22.2% false positives). Increases in circadian rhythm variables (25.0% true positives vs. 44.4% false positives) and decreases in activity levels (37.5% true positives vs. 44.4% false positives) were more common in participants without a transition. None of the tested risk indicators could confidently predict upcoming transitions in depression, but some evidence was found that critical-slowing-down-based EWSs were more common in participants with a transition.
Hypervigilance: An Understudied Mediator of the Longitudinal Relationship Between Stigma and Internalizing Psychopathology Among Sexual-Minority Young Adults
Authors: Hollinsaid Nathan L. , Pachankis John E. , Bränström Richard , Hatzenbuehler Mark L.
Published: March 2023

Hypervigilance is often theoretically invoked as a psychological mechanism linking stigma to internalizing psychopathology among sexual minorities. Empirically, however, hypervigilance is rarely explicitly assessed but is instead commonly conflated with putatively related constructs, including sexual-orientation-related rejection sensitivity and rumination, hindering conceptual and mechanistic understandings of this process. We therefore embedded a hypervigilance measure in a longitudinal, population-based study of 811 Swedish sexual-minority young adults (ages 17–34). Hypervigilance—but neither sexual-orientation-related rejection sensitivity nor rumination, with which it was only weakly correlated ( rs = .23–.24)—uniquely mediated prospective associations between perceived discrimination and internalizing symptoms 2 years later, explaining up to 40% of these effects. Sexual-orientation-related rejection sensitivity and rumination prospectively predicted hypervigilance on these paths. Findings suggest that hypervigilance represents a distinct construct and transdiagnostic mechanism through which stigma-related experiences and processes undermine sexual-minority mental health. We discuss implications for enhancing psychological interventions for sexual minorities by addressing hypervigilance.
Duodenal Trauma in Children: What is the Status of Non-Operative Conservative Treatment?
Authors: Zakarya Alami Hassani , Mouna Lazrak , Loubna Aqqaoui , Houda Oubejja , Mounir Erraji , Fouad Ettayebi , Hicham Zerhouni
Published: March 2023

Conservative treatment of duodenal trauma in children has long been the first line of treatment for duodenal wall hematomas. However, it has rarely been described in duodenal perforations. Our purpose is to highlight the possibility of conservative treatment in selected cases of duodenal perforation. In the period between 2009 and 2022, 6 children were treated for duodenal injury following abdominal blunt trauma in the pediatric surgical emergency department. The clinical presentation, diagnosis and treatment are reported and analyzed. Three patients presented with duodenal hematomas, they were treated non-operatively with hospital stays between 12 and 20 days and good clinical outcome. One child presented with duodenal hematoma and retroperitoneal air bubbles; non-operative conservative treatment was carried with favorable results. The fifth patient had a duodenal perforation; he underwent a primary duodenal 2-layers closure. The last patient had a combination of duodenal hematoma and perforation involving 75% of the duodenal diameter for which he underwent a gastro-jejunostomy with pyloric exclusion. An isolated duodenal lesion can be subject to a conservative treatment whenever allowed by a stable clinical condition and the availability of appropriate clinical and radiological monitoring.
Job quality continuity and change in later working life and the mediating role of mental and physical health on employment participation
Authors: Stiller Michael , Ebener Melanie , Hasselhorn Hans Martin
Published: March 2023

In times of demographic change, better job quality is needed to promote health and thereby extend employment participation among older workers. Past research has focussed on the investigation of single job quality characteristics, but neglected their combined effects on health and employment. To address this limitation, we have built upon an established typology based on nine job quality characteristics and representing five profiles of overall poor or good job quality constellations among manual and non-manual older workers, respectively. It was investigated how constant and changing job quality affects non-employment and how mental and physical health mediate this association. Analyses were based on representative data from N = 2,952 employees born in 1959 or 1965, who participated in all current waves (in the years 2011, 2014 and 2018) of the German lidA cohort study. Job quality was measured in 2011 and 2014 according to profile assignment per wave, composite mental and physical health scores from 2014 were used as mediators and non-employment (vs. employment) in 2018 represented the outcome. Two separate mediation models were calculated, one for manuals and one for non-manuals. Among manuals with constantly poor job quality, the risk of non-employment was increased through both poor mental and physical health. Deteriorating job quality increased this risk through poor mental health, while changing from manual to non-manual work reduced this risk through better physical health. Among non-manuals, poor job quality was not related to the risk of non-employment and no health effects were found to significantly mediate such a risk. In conclusion, the health risks of poor later-life job quality demand critical consideration to maintain employability, particularly of manual workers in poor quality jobs. Timely workplace improvements for certain groups are needed to increase employment participation in good health, thereby increasing efficiency and fairness of measures promoting longer working lives.
Favoring the hierarchical constraint in penalized survival models for randomized trials in precision medicine
Authors: Belhechmi Shaima , Le Teuff Gwénaël , De Bin Riccardo , Rotolo Federico , Michiels Stefan
Published: March 2023

Background

The research of biomarker-treatment interactions is commonly investigated in randomized clinical trials (RCT) for improving medicine precision. The hierarchical interaction constraint states that an interaction should only be in a model if its main effects are also in the model. However, this constraint is not guaranteed in the standard penalized statistical approaches. We aimed to find a compromise for high-dimensional data between the need for sparse model selection and the need for the hierarchical constraint.

Results

To favor the property of the hierarchical interaction constraint, we proposed to create groups composed of the biomarker main effect and its interaction with treatment and to perform the bi-level selection on these groups. We proposed two weighting approaches (Single Wald (SW) and likelihood ratio test (LRT)) for the adaptive lasso method. The selection performance of these two approaches is compared to alternative lasso extensions (adaptive lasso with ridge-based weights, composite Minimax Concave Penalty, group exponential lasso and Sparse Group Lasso) through a simulation study. A RCT (NSABP B-31) randomizing 1574 patients (431 events) with early breast cancer aiming to evaluate the effect of adjuvant trastuzumab on distant-recurrence free survival with expression data from 462 genes measured in the tumour will serve for illustration. The simulation study illustrates that the adaptive lasso LRT and SW, and the group exponential lasso favored the hierarchical interaction constraint. Overall, in the alternative scenarios, they had the best balance of false discovery and false negative rates for the main effects of the selected interactions. For NSABP B-31, 12 gene-treatment interactions were identified more than 20% by the different methods. Among them, the adaptive lasso (SW) approach offered the best trade-off between a high number of selected gene-treatment interactions and a high proportion of selection of both the gene-treatment interaction and its main effect.

Conclusions

Adaptive lasso with Single Wald and likelihood ratio test weighting and the group exponential lasso approaches outperformed their competitors in favoring the hierarchical constraint of the biomarker-treatment interaction. However, the performance of the methods tends to decrease in the presence of prognostic biomarkers.
In silico characterization of cysteine-stabilized αβ defensins from neglected unicellular microeukaryotes
Authors: Senra Marcus Vinicius Xavier
Published: March 2023

Background

The emergence of multi-resistant pathogens have increased dramatically in recent years, becoming a major public-health concern. Among other promising antimicrobial molecules with potential to assist in this worldwide struggle, cysteine-stabilized αβ (CS-αβ) defensins are attracting attention due their efficacy, stability, and broad spectrum against viruses, bacteria, fungi, and protists, including many known human pathogens.

Results

Here, 23 genomes of ciliated protists were screened and two CS-αβ defensins with a likely antifungal activity were identified and characterized, using bioinformatics, from a culturable freshwater species, Laurentiella sp. (LsAMP-1 and LsAMP-2). Although any potential cellular ligand could be predicted for LsAMP-2; evidences from structural, molecular dynamics, and docking analyses suggest that LsAMP-1 may form stably associations with phosphatidylinositol 4,5-bisphosphates (PIP2), a phospholipid found on many eukaryotic cells, which could, in turn, represent an anchorage mechanism within plasma membrane of targeted cells.

Conclusion

These data stress that more biotechnology-oriented studies should be conducted on neglected protists, such ciliates, which could become valuable sources of novel bioactive molecules for therapeutic uses.