bluuebunny/crossref_metadata_2025 huggingface dataset:
New distribution record of globally threatened Ocean Turf Grass Halophila beccarii Ascherson, 1871 from the North Andaman Islands highlights the importance of seagrass exploratory surveys
Authors: Swapnali Gole  , Prasad Gaidhani  , Srabani Bose  , Anant Pande  , Jeyaraj Antony Johnson  , Kuppusamy Sivakumar
Published: January 2022

Halophila beccarii, listed as ‘Vulnerable’ on the IUCN Red List, aids in seagrass and mangrove succession, acts as a substrate stabilizer and provides feeding grounds for mega-herbivores like dugongs. This species was first recorded from the Andaman & Nicobar Islands in 2015, and its distribution status within the archipelago remains under-investigated. We report a new distribution record of H. beccarii from the North Andamans and shed light on its inter-island distribution. H. beccarii was recorded from a mixed meadow comprising of Cymodocea rotundata (20.5 ± 28.8%, mean seagrass cover), Thalassia hemprichii (16.3 ± 23.3%, mean seagrass cover), and Halodule pinifolia (6.3 ± 12.1%, mean seagrass cover) at Pokkadera, North and Middle Andaman district. H. beccarii had the highest mean seagrass cover (30 ± 34.7%) and shoot density (103.5 ± 68.3 shoots/ m2) among sympatric seagrass species. We also recorded eight seagrass-associated macrofaunal groups (gastropods, bivalves, polychaetes, foraminiferans, nematodes, brachyurans, decapods and asteroids) from the infaunal and epibenthic micro-habitats within the meadow. Infaunal macrobenthos had a much higher density (73.5 ± 129.7 individuals/m2) than the epibenthic macrofauna (0.4 ± 1.5 individuals/m2), possibly influenced by the seagrass canopy structure and biomass. Overall, gastropods were the most dominant macrobenthic faunal group (overall mean 95.0 ± 106.1 individuals/m2). The present findings emphasize the need for more exploratory surveys to understand H. beccarii distribution in the Andaman & Nicobar archipelago to identify priority conservation areas.
Heart Disease and Stroke Statistics—2022 Update: A Report From the American Heart Association
Authors: Tsao Connie W. , Aday Aaron W. , Almarzooq Zaid I. , Alonso Alvaro , Beaton Andrea Z. , Bittencourt Marcio S. , Boehme Amelia K. , Buxton Alfred E. , Carson April P. , Commodore-Mensah Yvonne , Elkind Mitchell S.V. , Evenson Kelly R. , Eze-Nliam Chete , Ferguson Jane F. , Generoso Giuliano , Ho Jennifer E. , Kalani Rizwan , Khan Sadiya S. , Kissela Brett M. , Knutson Kristen L. , Levine Deborah A. , Lewis Tené T. , Liu Junxiu , Loop Matthew Shane , Ma Jun , Mussolino Michael E. , Navaneethan Sankar D. , Perak Amanda Marma , Poudel Remy , Rezk-Hanna Mary , Roth Gregory A. , Schroeder Emily B. , Shah Svati H. , Thacker Evan L. , VanWagner Lisa B. , Virani Salim S. , Voecks Jenifer H. , Wang Nae-Yuh , Yaffe Kristine , Martin Seth S. ,   on behalf of the American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee
Published: January 2022

Background:

The American Heart Association, in conjunction with the National Institutes of Health, annually reports the most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, diet, and weight) and health factors (cholesterol, blood pressure, and glucose control) that contribute to cardiovascular health. The Statistical Update presents the latest data on a range of major clinical heart and circulatory disease conditions (including stroke, congenital heart disease, rhythm disorders, subclinical atherosclerosis, coronary heart disease, heart failure, valvular disease, venous disease, and peripheral artery disease) and the associated outcomes (including quality of care, procedures, and economic costs).

Methods:

The American Heart Association, through its Statistics Committee, continuously monitors and evaluates sources of data on heart disease and stroke in the United States to provide the most current information available in the annual Statistical Update. The 2022 Statistical Update is the product of a full year’s worth of effort by dedicated volunteer clinicians and scientists, committed government professionals, and American Heart Association staff members. This year’s edition includes data on the monitoring and benefits of cardiovascular health in the population and an enhanced focus on social determinants of health, adverse pregnancy outcomes, vascular contributions to brain health, and the global burden of cardiovascular disease and healthy life expectancy.

Results:

Each of the chapters in the Statistical Update focuses on a different topic related to heart disease and stroke statistics.

Conclusions:

The Statistical Update represents a critical resource for the lay public, policymakers, media professionals, clinicians, health care administrators, researchers, health advocates, and others seeking the best available data on these factors and conditions.
The Role of Proximity in Technology Dynamics of High-Tech Industries: the Case of Biotechnology and Aviation Industries
Authors: Runiewicz-Wardyn Małgorzata
Published: January 2022

Confronted with new global competitive environment, rising R&D costs, growing integration of different technologies, shorter life cycles, and increased pace of innovation, high-tech companies increasingly collaborate with external partners. Innovation networks became unconditional driver of technological dynamics and growth of high-tech industries. The article aims to explore the role of proximity in innovation networks formation in the two high-tech industries – biotechnology and aviation. Both industries are characterized by different stages of technological maturity, different product life-cycles and development periods, yet both equally depend on highly specialized human capital and collaborative innovation. The article addresses the following research questions: What is the role of proximity – geographical, cognitive, institutional, organizational, social and cultural – in facilitating innovation networks formation in the above mentioned high-tech industries? What type of proximities and the related network externalities assist these industries along their life-cycles? What is the relationship between technology dynamics and innovation networks formation?
Leiocanthus quinquenudus sp. nov. and L. satanicus sp. nov., two new species of pycnophyid Kinorhyncha (Allomalorhagida: Pycnophyidae) from the Gulf of Mexico
Authors: CEPEDA DIEGO , SÁNCHEZ NURIA , SØRENSEN MARTIN V. , LANDERS STEPHEN C.
Published: January 2022

Two new species of pycnophyid Kinorhyncha, Leiocanthus quinquenudus sp. nov. and L. satanicus sp. nov., are described from soft seafloor sediment samples in the Gulf of Mexico. Leiocanthus quinquenudus sp. nov. is easily distinguished from the other congeners by the absence of ventromedial setae on segment 5, a structure otherwise present in all the other known Leiocanthus. Leiocanthus satanicus sp. nov. lacks lateral terminal spines, a feature only shared by L. langi and L. mainensis among the congeners; otherwise the new species is easily discernible by the arrangement of the paradorsal, laterodorsal and ventromedial setae, and the number of ventral sensory spots per segment. These findings are a significant contribution to the knowledge of the Kinorhyncha biodiversity from the Gulf of Mexico, which has recently been explored in several taxonomical and ecological studies mainly focused on cyclorhagid Kinorhyncha, not pycnophyid kinorhynchs.
Towards a revision of the bamboo corals (Octocorallia): Part 4, delineating the family Keratoisididae
Authors: WATLING LES , SAUCIER ESPRIT HEESTAND , FRANCE SCOTT C.
Published: January 2022

The systematics of bamboo corals of the Family Keratoisididae are evaluated using both DNA sequences and morphological data. Sequence data were obtained from 398 specimens, from which 77 unique haplotypes representing the mtMutS and 18S gene regions were identified. These were aligned with sequences downloaded from GenBank from an additional 12 keratoisids and 6 octocoral outgroups. Phylogenetic analyses recovered seven well-supported major clades, the most recently derived of which consists of several subclades. Each clade and subclade can be characterized by a suite of morphological characters that include axis construction, branching pattern, polyp form, and sclerite type and arrangement. This analysis also shows that keratoisid genera described >100 years ago are paraphyletic and need revision and that a large number of new genera will need to be described.
Contribution to the Chinese subfamily Rhaphidophorinae Walker, 1869 (Orthoptera: Rhaphidophoridae) V: Two new species of Eurhaphidophora
Authors: LU XIANGYI , HUANG XIAOJUAN , BIAN XUN
Published: January 2022

This paper describes two new species of Eurhaphidophora, namely: Eurhaphidophora curvata sp. nov. (Chinese name: 弯板优驼螽) and Eurhaphidophora fossa sp. nov. (Chinese name: 凹板优驼螽) based on the specimens from Yunnan Province, China. The type specimens are deposited in the Guangxi Normal University, Guilin, China.
Creative Music-Making with Digital Audio Workstations
Authors: Pendergast Seth
Published: January 2022

Interest in creative music technologies is on the rise among secondary students. Still, some music teachers are unsure how to integrate creative music technologies into their instruction. This article explores one versatile and powerful technology for the music classroom: digital audio workstations (DAWs). First, I discuss the central role of hyphenated musicianship in DAW-based music-making. Second, I explore a guiding framework for DAW-based creative projects in the music classroom. Third, I outline three initial projects for free or low-cost DAWs, each addressing fundamental musical, creative, and technological concepts for DAW-based music-making. The ideas and projects described in this article offer a practical pathway toward introductory DAW-based competencies and pedagogy, especially for music teachers inexperienced with DAW technologies.
Human brain functional MRS reveals interplay of metabolites implicated in neurotransmission and neuroenergetics
Authors: Koush Yury , Rothman Douglas L , Behar Kevin L , de Graaf Robin A , Hyder Fahmeed
Published: January 2022

While functional MRI (fMRI) localizes brain activation and deactivation, functional MRS (fMRS) provides insights into the underlying metabolic conditions. There is much interest in measuring task-induced and resting levels of metabolites implicated in neuroenergetics (e.g., lactate, glucose, or β-hydroxybutyrate (BHB)) and neurotransmission (e.g., γ-aminobutyric acid (GABA) or pooled glutamate and glutamine (Glx)). Ultra-high magnetic field (e.g., 7T) has boosted the fMRS quantification precision, reliability, and stability of spectroscopic observations using short echo-time (TE) 1H-MRS techniques. While short TE 1H-MRS lacks sensitivity and specificity for fMRS at lower magnetic fields (e.g., 3T or 4T), most of these metabolites can also be detected by J-difference editing (JDE) 1H-MRS with longer TE to filter overlapping resonances. The 1H-MRS studies show that JDE can detect GABA, Glx, lactate, and BHB at 3T, 4T and 7T. Most recently, it has also been demonstrated that JDE 1H-MRS is capable of reliable detection of metabolic changes in different brain areas at various magnetic fields. Combining fMRS measurements with fMRI is important for understanding normal brain function, but also clinically relevant for mechanisms and/or biomarkers of neurological and neuropsychiatric disorders. We provide an up-to-date overview of fMRS research in the last three decades, both in terms of applications and technological advances. Overall the emerging fMRS techniques can be expected to contribute substantially to our understanding of metabolism for brain function and dysfunction.
Characterizing region-specific glucose metabolic profile of the rodent brain using Seahorse XFe96 analyzer
Authors: Wang Linshu , Chaudhari Kiran , Winters Ali , Sun Yuanhong , Liu Ran , Yang Shao-Hua
Published: January 2022

The brain is highly complex with diverse structural characteristics in accordance with specific functions. Accordingly, differences in regional function, cellular compositions, and active metabolic pathways may link to differences in glucose metabolism at different brain regions. In the current study, we optimized an acute biopsy punching method and characterized region-specific glucose metabolism of rat and mouse brain by a Seahorse XFe96 analyzer. We demonstrated that 0.5 mm diameter tissue punches from 180-µm thick brain sections allow metabolic measurements of anatomically defined brain structures using Seahorse XFe96 analyzer. Our result indicated that the cerebellum displays a more quiescent phenotype of glucose metabolism than cerebral cortex, basal ganglia, and hippocampus. In addition, the cerebellum has higher AMPK activation than other brain regions evidenced by the expression of pAMPK, upstream pLKB1, and downstream pACC. Furthermore, rodent brain has relatively low mitochondrial oxidative phosphorylation efficiency with up to 30% of respiration linked to proton leak. In summary, our study discovered region-specific glucose metabolic profile and relative high proton leak coupled respiration in the brain. Our study warrants future research on spatial mapping of the brain glucose metabolism in physiological and pathological conditions and exploring the mechanisms and significance of mitochondrial uncoupling in the brain.
Haemorrhagic complications following cataract and vitreoretinal surgery with sub-Tenon’s block in patients receiving non–vitamin K oral anticoagulant agents: A prospective audit
Authors: Guise Philip A , Wang Kailun
Published: January 2022

There is a lack of data to support either continuation or interruption of non–vitamin K oral anticoagulants for cataract and vitreoretinal surgery. A prospective audit was undertaken of 291 patients undergoing cataract surgery or vitreoretinal surgery, predominantly under sub-Tenon’s block, while continuing these agents. The median time from last non–vitamin K oral anticoagulant dose to the insertion of sub-Tenon’s block was five hours. No patient required emergency reversal of anticoagulation. There were no sight-threatening complications in the immediate perioperative period, although two vitreoretinal patients (3.8%) had a moderate haemorrhagic complication on day five, and two cataract patients (0.8%) had a minor haemorrhagic complication on days one and 14 postoperatively. Despite continuing their non–vitamin K oral anticoagulants, three (1%) cataract patients had a moderate thromboembolic complication within the 30-day postoperative period. The risk of haemorrhagic complications associated with continuation of anticoagulation with non–vitamin K oral anticoagulants for cataract and vitreoretinal surgery is low, and this audit supports the continuation of non–vitamin K oral anticoagulants for our patients having cataract and vitreoretinal surgery.
Experiencing Live Action of Business: Reflections on an Immersive Course in Entrepreneurship
Authors: Vohra Neharika , Sharma Supriya , Thomas Nobin
Published: January 2022

This article describes an experiential, immersive course in teaching for entrepreneurship in a business school. The course requires the students to set up and operate a business, build on their experiences, reflect upon it regularly and relate it to concepts in business and entrepreneurship. The design of the course, allowing for an immersive experience and reflection, is guided by Kolb’s experiential learning method, process philosophy and effectual thinking. Five themes of students’ learning, as generated from the weekly reflections submitted in the course, are presented. The themes primarily dwell upon attitudes, failures and experience of effectuation in operating an early-stage business. Insights on teaching for entrepreneurship, generated from the course and reflection of the instructors’ experience, are presented. Questions relevant for theory and practice on/of teaching for entrepreneurship are raised.
Epidemiology of NCAA Track and Field Injuries From 2010 to 2014
Authors: Hopkins Chris , Williams Joel , Rauh Mitchell J. , Zhang Lu
Published: January 2022

Background:

Track and field (T&F) athletes compete in a variety of events that require different skills and training characteristics. Descriptive epidemiology studies often fail to describe event-specific injury patterns.

Purpose:

To describe the epidemiology of injuries in National Collegiate Athletic Association (NCAA) T&F by sex, setting (practice vs competition), and time of season (indoor vs outdoor) and to compare injury patterns by events within the sport.

Study Design:

Descriptive epidemiology study.

Methods:

Data were obtained from the NCAA Injury Surveillance Program for all indoor and outdoor T&F injuries during the academic years 2009-2010 to 2013-2014. Injury rates, injury rate ratios, and injury proportion ratios (IPRs) were reported and compared by sex, injury setting, season, and event. Analysis included time-loss as well as no-time loss injuries.

Results:

Over the 5 seasons, the overall injury rate was 3.99 injuries per 1000 athletic-exposures (95% CI, 3.79-4.20). After controlling for injury diagnoses, women’s T&F athletes experienced an 18% higher risk of injury (95% CI, 7% to 31%) and missed 41% more time after an injury (95% CI, 4% to 93%) when compared with men. Among all athletes, the injury risk during competition was 71% higher (95% CI, 50% to 95%) compared with practice and required 59% more time loss (95% CI, 7% to 135%). Distance running accounted for a significantly higher proportion of overuse injuries (IPR, 1.70; 95% CI, 1.40-2.05; P < .05) and required 168% more time loss (95% CI, 78% to 304%) than other events. The hip and thigh were the body regions most commonly injured; injury type, however, varied by T&F event. Sprinting accounted for the greatest proportion of hip and thigh injuries, distance running had the greatest proportion of lower leg injuries, and throwing reported the greatest proportion of spine and upper extremity injuries.

Conclusion:

Injury risk in NCAA T&F varied by sex, season, and setting. Higher injury rates were found in women versus men, indoor versus outdoor seasons, and competitions versus practices. The hip and thigh were the body regions most commonly injured; however, injury types varied by event. These findings may provide insight to programs aiming to reduce the risk of injury and associated time loss in collegiate T&F.
Follow-up of patients with R/R FLT3-mutation–positive AML treated with gilteritinib in the phase 3 ADMIRAL trial
Authors: Perl Alexander E. , Larson Richard A. , Podoltsev Nikolai A. , Strickland Stephen , Wang Eunice S. , Atallah Ehab , Schiller Gary J. , Martinelli Giovanni , Neubauer Andreas , Sierra Jorge , Montesinos Pau , Récher Christian , Yoon Sung-Soo , Hosono Naoko , Onozawa Masahiro , Chiba Shigeru , Kim Hee-Je , Hasabou Nahla , Lu Qiaoyang , Tiu Ramon , Levis Mark J.
Published: January 2022

The phase 3 ADMIRAL (NCT02421939; Study ID: 2215-CL-0301) trial showed superior overall survival in patients with relapsed/refractory FLT3-mutation–positive acute myeloid leukemia (AML) randomized 2:1 to receive the oral FMS-like tyrosine kinase 3 inhibitor gilteritinib vs those randomized to receive salvage chemotherapy (SC). Here we provide a follow-up of the ADMIRAL trial 2 years after the primary analysis to clarify the long-term treatment effects and safety of gilteritinib in these patients with AML. At the time of this analysis, the median survival follow-up was 37.1 months, with deaths in 203 of 247 and 97 of 124 patients in the gilteritinib and SC arms, respectively; 16 gilteritinib-treated patients remained on treatment. The median overall survival for the gilteritinib and SC arms was 9.3 and 5.6 months, respectively (hazard ratio, 0.665; 95% confidence interval [CI], 0.518, 0.853; two-sided P = .0013); 2-year estimated survival rates were 20.6% (95% CI, 15.8, 26.0) and 14.2% (95% CI, 8.3, 21.6). The gilteritinib-arm 2-year cumulative incidence of relapse after composite complete remission was 75.7%, with few relapses occurring after 18 months. Overall, 49 of 247 patients in the gilteritinib arm and 14 of 124 patients in the SC arm were alive for ≥2 years. Twenty-six gilteritinib-treated patients remained alive for ≥2 years without relapse; 18 of these patients underwent transplantation (hematopoietic stem cell transplantation [HSCT]) and 16 restarted gilteritinib as post-HSCT maintenance therapy. The most common adverse events of interest during years 1 and 2 of gilteritinib therapy were increased liver transaminase levels; adverse event incidence decreased in year 2. Thus, continued and post-HSCT gilteritinib maintenance treatment sustained remission with a stable safety profile. These findings confirm that prolonged gilteritinib therapy is safe and is associated with superior survival vs SC. This trial was registered at www.clinicaltrials.gov as #NCT02421939.
Three US Food and Drug Administration–approved therapies for chronic GVHD
Authors: Zeiser Robert , Lee Stephanie J.
Published: January 2022

Chronic graft-versus-host disease (cGVHD) is a major immunologic complication of allogeneic hematopoietic cell transplantation. cGVHD involves multiple organs, reduces quality of life, and often requires prolonged therapy with glucocorticoids, causing severe side effects. After 4 decades of testing multiple therapeutic approaches, ibrutinib, belumosudil, and ruxolitinib were US Food and Drug Administration approved for cGVHD in the last 4 years. Here we put a spotlight on their mechanisms of action, studies that led to approval, and their future role in cGVHD.
Current unmet needs and potential solutions to uncontrolled asthma
Authors: Busse William W. , Kraft Monica
Published: January 2022

Despite the availability of effective inhaled therapies, many patients with asthma have poor asthma control. Uncontrolled asthma presents a significant burden on the patient and society, and, for many, remains largely preventable. There are numerous reasons why a patient may remain uncontrolled despite access to therapies, including incorrect inhaler technique, poor adherence to treatment, oversight of triggers and suboptimal medical care. Shared decision-making, good patient–clinician communication, supported self-management, multidisciplinary patient education, new technology and risk stratification may all provide solutions to this major unmet need in asthma. Novel treatments such as biologics could benefit patients’ lives, while the investigations into biomarkers, non-Type 2 asthma, treatable traits and disease modification give an exciting glimpse into the future of asthma care.
A deep learning approach to predict inter-omics interactions in multi-layer networks
Authors: Borhani Niloofar , Ghaisari Jafar , Abedi Maryam , Kamali Marzieh , Gheisari Yousof
Published: January 2022

Background

Despite enormous achievements in the production of high-throughput datasets, constructing comprehensive maps of interactions remains a major challenge. Lack of sufficient experimental evidence on interactions is more significant for heterogeneous molecular types. Hence, developing strategies to predict inter-omics connections is essential to construct holistic maps of disease.

Results

Here, as a novel nonlinear deep learning method, Data Integration with Deep Learning (DIDL) was proposed to predict inter-omics interactions. It consisted of an encoder that performs automatic feature extraction for biomolecules according to existing interactions coupled with a predictor that predicts unforeseen interactions. Applicability of DIDL was assessed on different networks, namely drug–target protein, transcription factor-DNA element, and miRNA–mRNA. Also, validity of the novel predictions was evaluated by literature surveys. According to the results, the DIDL outperformed state-of-the-art methods. For all three networks, the areas under the curve and the precision–recall curve exceeded 0.85 and 0.83, respectively.

Conclusions

DIDL offers several advantages like automatic feature extraction from raw data, end-to-end training, and robustness to network sparsity. In addition, reliance solely on existing inter-layer interactions and independence of biochemical features of interacting molecules make this algorithm applicable for a wide variety of networks. DIDL paves the way to understand the underlying mechanisms of complex disorders through constructing integrative networks.
Resveratrol ameliorates myocardial fibrosis by regulating Sirt1/Smad3 deacetylation pathway in rat model with dilated cardiomyopathy
Authors: Chen Qingquan , Zeng Yu , Yang Xiulin , Wu Yue , Zhang Shuyu , Huang Shirong , Zhong Yameng , Chen Min
Published: January 2022

Background

The aim of this study was to investigate the effects of Resveratrol (RSV) in rats with dilated cardiomyopathy (DCM).

Methods

Porcine cardiac myosin was used to set up rat model with DCM. RSV (10 mg/kg in RSV-L group and 50 mg/kg in RSV-H group) or vehicle was administered to rats with DCM once daily from the 28th day till the 90th day after the first immunization. Cardiac function of rats was evaluated by echocardiographic analysis. The deposition of fibrous tissues in the hearts was evaluated by Masson and picrosirius red staining. The mRNA levels of collagen type I (Col I), collagen type III (Col III) and silence information regulator 1 (Sirt1) were measured by quantitative real-time polymerase chain reaction (qRT-PCR). The interaction of Sirt1 with Smad3 was revealed by coimmunoprecipitation.

Results

The heart weight, heart weight/body weight ratio, left ventricular end diastolic diameter (LVEDD) and left ventricular end systolic diameter (LVESD) were significantly increased in rats with DCM, and attenuated by RSV. RSV also positively decreased fibrosis, and the expression of Col I and Col III in the myocardium. The Sirt1 mRNA was significantly decreased in myosin-immunized hearts and was positively increased by RSV. The Sirt1 combined with Smad3 directly. Acetylation of Smad3 (Ac-Smad3) was significantly increased in DCM and was markedly decreased by RSV.

Conclusion

RSV effectively ameliorated myocardial fibrosis and improved cardiac function by regulating Sirt1/Smad3 deacetylation pathway in rat model with DCM.
Comparing methods of adenosine administration in paroxysmal supraventricular tachycardia: a pilot randomized controlled trial
Authors: Daengbubpha Phruek , Wittayachamnankul Borwon , Sutham Krongkarn , Chenthanakij Boriboon , Tangsuwanaruk Theerapon
Published: January 2022

Background

Intravenous adenosine is the recommended treatment for paroxysmal supraventricular tachycardia (PSVT). There is no official recommended method of giving adenosine. We compared the success rates between a standard and alternative method of first dose intravenous adenosine in PSVT.

Methods

A pilot parallel randomized controlled study was conducted in the emergency department of a tertiary care hospital. Eligible patients were stable PSVT adult patients. We used block randomization and divided them into two groups, the standard method (double syringe technique of 6 mg of adenosine), and the alternative method (similar to the standard method, then immediately followed by elevating the arm to 90° perpendicular to a horizontal plane for 10 s). The primary outcome was the success rate of electrocardiogram (ECG) response which demonstrated termination of PSVT (at least two-fold of the RR-interval widening or sinus rhythm conversion). Secondary outcomes were complications within one minute after the injection.

Results

We allocated 15 patients in each group and analyzed them as intention-to-treat. The success rate was 86.7% in the alternative group and 80% in the standard group (risk difference 6.7%, 95% confidence interval − 19.9 to 33.2%, P 1.00). Complications within one minute after adenosine injection were also similar in both groups, 14 of 15 patients (93%) in each group had no complications, without significant difference.

Conclusions

No evidence of the difference between alternative and standard methods occurred, in terms of the success rate of ECG response and complications within one minute after adenosine injection. The standard method of adenosine injection is a safe, easy-to-administer, and widely available treatment for PSVT.

Trial Registration: TCTR20200609001.
The utilization of primary healthcare services among frail older adults – findings from the Helsinki Birth Cohort Study
Authors: Ikonen Jenni N , Eriksson Johan G , von Bonsdorff Mikaela B , Kajantie Eero , Arponen Otso , Haapanen Markus J
Published: January 2022

Background

The impact of frailty on primary healthcare service use, especially general practice office visits and remote contacts, is currently unknown. Further, little is known about the association of frailty with physiotherapy contacts.

Methods

We examined the utilization of primary healthcare services among 1064 participants from the Helsinki Birth Cohort Study between the years 2013 and 2017. Frailty was assessed based on Fried’s frailty criteria at mean age of 71.0 (2.7 SD) years in clinical examinations between the years 2011 and 2013. General practice office visits and remote contacts, the total number of general practice contacts, physiotherapy contacts, and the total number of primary healthcare contacts were extracted from a national Finnish register. We analyzed the data with negative binomial regression models.

Results

Of the 1064 participants, 37 were frail (3.5%) and 427 pre-frail (40.1%); 600 non-frail (56.4%) served as a reference group. Frailty was associated with general practice office visits (IRR 1.31, 95% CI=1.01-1.69), physiotherapy contacts (IRR 2.97, 95% CI=1.49-5.91) and the total number of primary healthcare contacts (IRR 1.41, 95% CI=1.07-1.85). Pre-frailty predicted the use of general practice remote contacts (IRR 1.39, 95% CI=1.22-1.57) and the total number of general practice contacts (IRR 1.25, 95% CI=1.12-1.40).

Conclusions

Frailty increases the overall primary healthcare service use whereas pre-frailty is associated with the use of general practice services, especially remote contacts. Primary healthcare needs measures to adapt healthcare services based on the needs of rapidly increasing number of pre-frail and frail older adults and should consider preventative interventions against frailty.
The impact of ethnic minority status on tuberculosis diagnosis and treatment delays in Hunan Province, China
Authors: Gilmour Beth , Xu Zuhui , Bai Liqiong , Alene Kefyalew Addis , Clements Archie C. A.
Published: January 2022

Background

Tuberculosis (TB) continues to be a major public health challenge in China. Understanding TB management delays within the context of China’s unique ethnic diversity may be of value in tackling the disease. This study sought to evaluate the impact of ethnic minority status on TB diagnosis and treatment delays.

Methods

This retrospective cohort study was conducted on patients diagnosed with TB in Hunan Province, China between 2013 and 2018. Diagnosis delay was defined as the time interval between the onset of symptoms and the date of diagnosis. Treatment delay was defined as the time interval between diagnosis and treatment commencement. Univariable and multivariable logistic regression models were used to identify factors associated with TB diagnosis and treatment delay, including ethnic minority status. Adjusted odds ratios (AOR) with 95% confidence intervals (CI) were calculated to assess the strength of association between the dependant and independent variables.

Results

A total of 318,792 TB patients were included in the study with a mean age of 51.7 years (SD 17.7). The majority of patients were male (72.6%) and Han ethnicity (90.6%). The odds of experiencing diagnosis delay (> 21 days) were significantly higher for Tujia (AOR: 1.46, 95% CI: 1.41, 1.51), Miao (AOR: 1.31, 95% CI: 1.26, 1.37), Dong (AOR: 1.97, 95% CI: 1.85, 2.11), Yao (AOR: 1.27, 95% CI: 1.17, 1.37), and Bai (AOR: 1.45, 95% CI: 1.22, 1.74) ethnic minorities compared to the Han majority. The odds of experiencing treatment delay (> 15 days) were significantly lower for five of the seven ethnic minority groups relative to the Han majority: Tujia (AOR 0.92, 95% CI 0.88, 0.96), Miao (AOR 0.74, 95% CI 0.70, 0.79), Dong (AOR 0.87, 95% CI 0.81, 0.95), Yao (AOR 0.20, 95% CI 0.17, 0.24) and ‘other’ (ethnic minorities that individually represented < 0.1% of the patient population) (AOR 0.70, 955 CI 0.51, 0.97).

Conclusions

This study shows ethnic minority status to be a significant risk factor in diagnosis delay, but for it to reduce the odds of treatment delay. Further research is required to determine the underlying causes of diagnosis delay within ethnic minority populations.
The mental health crisis of expectant women in the UK: effects of the COVID-19 pandemic on prenatal mental health, antenatal attachment and social support
Authors: Filippetti Maria Laura , Clarke Alasdair D. F. , Rigato Silvia
Published: January 2022

Background

Pregnancy has been shown to be times in a woman’s life particularly prone to mental health issues, however a substantial percentage of mothers report subclinical perinatal mental health symptoms that go undetected. Experiences of prenatal trauma, such as the COVID-19 pandemic, may exacerbate vulnerability to negative health outcomes for pregnant women and their infants. We aimed to examine the role of: 1) anxiety, depression, and stress related to COVID-19 in predicting the quality of antenatal attachment; 2) perceived social support and COVID-19 appraisal in predicting maternal anxiety and depression.

Methods

A sample of 150 UK expectant women were surveyed during the COVID-19 pandemic. Questions included demographics, pregnancy details, and COVID-19 appraisal. Validated measures were used to collect self-reported maternal antenatal attachment (MAAS), symptoms of anxiety (STAI), depression (BDI-II), and stress related to the psychological impact of COVID-19 (IES-r).

Results

We found that the pandemic has affected UK expectant mothers’ mental health by increasing prevalence of depression (47%), anxiety (60%) and stress related to the psychological impact of COVID-19 (40%). Women for whom COVID-19 had a higher psychological impact were more likely to suffer from depressive (95% HDPI = [0.04, 0.39]) and anxiety symptoms (95% HPDI = [0.40, 0.69]). High depressive symptoms were associated with reduced attachment to the unborn baby (95% HPDI [-0.46, -0.1]). Whilst women who appraised the impact of COVID-19 to be more negative showed higher levels of anxiety (HPDI = [0.15, 0.46]), higher social support acted as a protective factor and was associated with lower anxiety (95% HPDI = [-0.52, -0.21]).

Conclusions

The current findings demonstrate that direct experience of prenatal trauma, such as the one experienced during the COVID-19 pandemic, significantly amplifies mothers’ vulnerability to mental health symptoms and impairs the formation of a positive relationship with their unborn baby. Health services should prioritise interventions strategies aimed at fostering support for pregnant women.
Novel compound heterozygous variants in XYLT1 gene caused Desbuquois dysplasia type 2 in an aborted fetus: a case report
Authors: Rajabi Fatemeh , Bereshneh Ali Hosseini , Ramezanzadeh Mahboubeh , Garshasbi Masoud
Published: January 2022

Background

Desbuquois dysplasia type 2 (DBQD2) is an infrequent dysplasia with a wide range of symptoms, including facial deformities, growth retardation and short long bones. It is an autosomal recessive disorder caused by mutations in the XYLT1 gene that encodes xylosyltransferase-1.

Case presentation

We studied an aborted fetus from Iranian non-consanguineous parents who was therapeutically aborted at 19 weeks of gestation. Ultrasound examinations at 18 weeks of gestation revealed growth retardation in her long bones and some facial problems. Whole-exome sequencing was performed on the aborted fetus which revealed compound heterozygous XYLT1 mutations: c.742G>A; p.(Glu248Lys) and c.1537 C>A; p.(Leu513Met). Sanger sequencing and segregation analysis confirmed the compound heterozygosity of these variants in XYLT1.

Conclusion

The c.1537 C>A; p.(Leu513Met) variant has not been reported in any databases so far and therefore is novel. This is the third compound heterozygote report in XYLT1 and further supports the high heterogeneity of this disease.
Is age of self-harm onset associated with increased frequency of non-suicidal self-injury and suicide attempts in adolescent outpatients?
Authors: Brager-Larsen Anne , Zeiner Pål , Klungsøyr Ole , Mehlum Lars
Published: January 2022

Background

Self-harm in adolescents is an increasing public health concern and an important risk factor for suicide. We aimed to examine how age of self-harm onset in adolescents was associated with frequency of subsequent suicidal and non-suicidal self-harm (NSSI) episodes, and how age of onset and duration of self-harm may influence the frequency of self-harm.

Methods

Data from 103 adolescents with recurrent self-harm recruited from child and adolescent psychiatric outpatient clinics were collected through clinical interviews and self-reports, and analysed with negative binomial and hurdle models.

Results

A lower age of self-harm onset and a longer duration of self-harm were both significantly associated with increased frequency of subsequent episodes of NSSI and risk of a first suicide attempt. There was an increase in repeated suicide attempts when the age of onset of self-harm decreased and the duration increased, and dramatically more for long duration of NSSI before first suicide attempt.

Conclusion

Initiating self-harm behaviour at the youngest age had the highest risk of increased frequency of NSSI and suicide attempts. Longer duration of self-harm behaviour increased this risk. This underlines the importance of early identification of self-harm behaviour in adolescents, and the use of effective interventions.
Association between comorbidity and health-related quality of life in a hypertensive population: a hospital-based study in Bangladesh
Authors: Mannan Adnan , Akter Kazi Mahmuda , Akter Farhana , Chy Naim Uddin Hasan A , Alam Nazmul , Pinky Susmita Dey , Chowdhury Abul Faisal Md. Nuruddin , Biswas Parijat , Chowdhury Afrin Sultana , Hossain Mohammed Akram , Rana Md. Mashud
Published: January 2022

Background

Hypertension is a known risk factor for several chronic conditions including diabetes and cardiovascular diseases. However, little is known about its impact on Health-related quality of life (HRQoL) in the context of Bangladesh. This study aimed to evaluate the association of hypertension on HRQoL among Bangladeshi patients corresponding to the socio-demographic condition, comorbid conditions, treatment, and health outcomes.

Methods

A hospital based cross-sectional study was conducted using a pre-tested structured questionnaire among patients with hypertension in 22 tertiary medical college hospitals in Bangladesh. The study recruited male and female hypertensive patients of age ≥18 years between July 2020 to February 2021 using consecutive sampling methods. Health related quality of life was measured using the widely-used index of EQ-5D that considers 243 different health-related attributes and uses a scale in which 0 indicates a health state equivalent to death and 1 indicates perfect health status. The five dimensions of the quality index included mobility, self-care, usual activities, pain or discomfort, and anxiety or depression. Ordered logit regression and linear regression models were used to estimate the predictors of comorbidity and HRQoL.

Results

Of the 1,912 hypertensive patients, 56.2% were female, 86.5% were married, 70.7% were either overweight or obese, 67.6% had a family history of hypertension, and 85.5% were on anti-hypertensive medication. Among the individuals with comorbidities, 47.6% had diabetes, 32.3% were obese, 16.2% had heart disease, 15% were visually impaired, and 13.8% were suffering from psychological diseases. HRQoL was found to be inversely proportional to the number of comorbidities. The most frequent comorbidities of diabetes and obesity showed the highest EQ- 5D mean utilities of 0.59 and 0.64, respectively.

Conclusions

Prevalent comorbidities, diabetes and obesity were found to be the significant underlying causes of declining HRQoL. It is recommended that the comorbidities should be adequately addressed for better HRQoL. Special attention should be given to address mental health issues of patients with hypertension.
Association between satellite-detected tropospheric nitrogen dioxide and acute respiratory infections in children under age five in Senegal: spatio-temporal analysis
Authors: Kawano Ayako , Kim Yoonhee , Meas Michelle , Sokal-Gutierrez Karen
Published: January 2022

Background

There is growing evidence to suggest that exposure to a high concentration of nitrogen dioxide (NO2) can lead to a higher incidence of Acute Respiratory Infections (ARIs) in children; however, such an association remains understudied in Sub-Saharan Africa due to the limited availability of exposure data. This study explored this association by using the satellite-detected tropospheric NO2 concentrations measured by Sentinel-5 Precursor
and ARI symptoms in children under age five collected in the Demographic and Health Survey (DHS) in Senegal.

Methods

We matched the daily tropospheric NO2 exposure with the individual ARI symptoms according to the DHS survey clusters spatially and temporally and conducted a logistic regression analysis to estimate the association of exposure to NO2 with ARI symptoms in two preceding weeks.

Results

We observed a positive association between exposure to continuous levels of NO2 and ARI symptoms after adjusting for confounders (OR 1.27 per 10 mol/m2, 95% CI: 1.06 – 1.52). When the association was further examined by quartile exposure categories, the 4th quartile category was positively associated with symptoms of ARI after adjusting for confounders (OR 1.71, 95% CI: 1.08—2.69). This suggests that exposure to certain high levels of NO2 is associated with the increased risk of children having symptoms of ARI in Senegal.

Conclusions

This study highlights the need for increased research on the effects of ambient NO2 exposure in Africa as well as the need for more robust, ground-based air monitoring in the region. For a country like Senegal, where more than 90% of the population lives in areas that do not meet the national air quality standards, it is urgently required to implement air pollution prevention efforts to protect children from the health hazards of air pollution.
Laparoscopic vs open Ladd’s procedure for malrotation in neonates and infants: a propensity score matching analysis
Authors: Xie Weike , Li Zhongwen , Wang Qi , Wang Lei , Pan Yongkang , Lu Chaoxiang
Published: January 2022

Background

Laparoscopic Ladd’s procedure for malrotation in children is still a controversial approach. Although some retrospective studies have compared the outcomes of the two types of procedure with inconsistency outcomes. Currently, there are few large-scale studies on laparoscopic treatment in malrotation with neonates and infants. We did a study based on propensity score matching to compare the effects of the two kinds of approach in neonates and infants. To investigate the therapeutic effect of laparoscopy and open Ladd’s procedure by the propensity score-matching (PSM) to enhance the validity of the comparison.

Methods

A total series of 143 cases of intestinal malrotation without intestinal necrosis was included in the study during the 8 years from January 2012 to January 2020, including 68 cases of open Ladd’s procedure and 75 cases of laparoscopic Ladd’s procedure including five cases of transfer laparotomy. By a propensity score 1:1 matching, 62 patients were stratified for each group.

Results and conclusion

There was no significant difference in volvulus degree, weight and gender between the two groups (p > 0.05). Laparoscopic surgery took more time than open surgery (105.9 min vs 70.6 min, p < 0.05), but it had less hospital stay (12.4 days vs 14.6 days, p < 0.05) or less incision infection (0 vs 6, p < 0.05). There was no significant difference between the two groups at the time of first defecation, blood loss, time of full feeding and reoperation (p > 0.05). The cosmetic effect of laparoscopic surgery is better than that of open surgery. Laparoscopic Ladd’s procedure is a safe approach. It can reduce the length of hospital stay and incision infection, but the operation time was extended, the other complications are similar compared with open procedure for intestinal malrotation in neonates and infants.
The short-term effects of COVID-19 on HIV and AIDS control efforts among female sex workers in Indonesia
Authors: Magnani Robert J. , Wirawan Dewa Nyoman , Sawitri Anak Agung Sagung , Mahendra I. Gusti Agung Agus , Susanti Dewi , Utami Ds Ni Kadek Ayu Dwi , Asanab Dedison , Yunus Jessie Olivia , Setiabudi Cahyo Heri , Nugroho Adi , Widihastuti Asti Setiawati , Mukuan Oldri Sherli , Januraga Pande Putu
Published: January 2022

Background

The COVID-19 pandemic has raised concerns as to its impact on other health programs. One program that appears particularly vulnerable is HIV and AIDS. We undertook an assessment of COVID-19 impact on HIV control efforts in Indonesia for a sub-population that has received little attention in the global literature—female sex workers (FSW).

Methods

The study was undertaken in 23 National AIDS program priority districts. Four sources of monthly data during January–July 2020 were considered. COVID-19 infection data were extracted from national and district surveillance systems. Combination prevention program outputs were reported by civil society organizations (CSOs) providing community support services to FSW. These organizations also undertook monthly scans of levels of commercial sex activity and HIV testing availability. We also considered data from an ongoing HIV community screening trial. The primary mode of analysis entailed comparisons of levels and trends of indicators from the four data series.

Results

Commercial sex activity was severely curtailed in April–May in many districts. While recovering to pre-COVID-19 levels in “Localization” areas, the number of active FSW in July was one-third below that in February. HIV testing service availability declined by 50% at health facilities before recovering slowly, while mobile clinic services largely ceased during April–June. Numbers of FSW reached, condoms distributed, FSW tested for HIV, HIV cases detected, and FSW starting treatment all declined precipitously in April/May but had largely recovered to pre-COVID-19 levels by July. We found only a temporary dip in treatment initiation rates among HIV positive FSW and no discernible impact on treatment retention. The HIV community screening trial data revealed significant demand for HIV testing among FSW that was not being met even before the onset of COVID-19.

Conclusions

COVID-19 has had at least short-run economic effects on FSW and the national response to HIV and AIDS targeting FSW. However, the effects appear to have been cushioned by community-based services and support in study districts. The findings make a compelling case for the expansion of community-based services irrespective of the future trajectory of COVID-19. As COVID-19 has not yet been contained, the trajectory of economic activity and service delivery is uncertain.