bluuebunny/crossref_metadata_2025 huggingface dataset:
Second Primary Renal Cell Carcinoma With Nonrenal Malignancies: An Analysis of 118 Cases and a Review of Literature
Authors: Chen Jinchao , Qi Nienie , Wang Hua , Wang Zongping , He Yedie , Zhu Shaoxing
Published: December 2021

Objectives

To evaluate the nature, diagnosis, treatment and prognosis of second primary renal cell carcinoma (SPRCC).

Materials and Methods

We retrospectively collected data from 118 patients with SPRCC. Clinical characteristics, imaging features and treatments were analyzed and comparisons between SPRCC and renal metastases (RM) were made.

Results

SPRCC accounts for 11.4% of all RCC. The most common types of extrarenal malignancies included lung, colorectal, breast and gynecological cancers. The median age was 58.5 years old, and 61.0% (72/118) of the patients were male. About 5.1% of the patients presented with symptoms. The average tumor diameter was 4.4 cm (1-8.4 cm). The diagnostic specificity of enhanced computed tomography (CT) was 80.1%. When comparing with RM, more patients with stage I–II extrarenal malignancy and less patients with bilateral, multiple, and endogenic renal masses on computed tomography were found in the SPRCC group. A total of 110 SPRCC patients underwent surgery, including 48 radical nephrectomies and 62 partial nephrectomies. The median overall survival time was 117 months. Female, asymptomatic status, no distant metastasis, and surgical treatment predicted a better survival.

Conclusions

SPRCC are not uncommon, and it should be considered during the follow-up of patients with nonrenal malignancy. The differential diagnosis between SPRCC and RM was mainly based on imaging and puncture biopsy.
Cryotherapy for Prevention of Taxane-Induced Peripheral Neuropathy: A Meta-Analysis
Authors: Jia Junting , Guo Yimeng , Sundar Raghav , Bandla Aishwarya , Hao Zhiying
Published: December 2021

Purpose

Taxanes are widely used in gynecological cancer therapy, however, taxane-induced peripheral neuropathy (TIPN) limits chemotherapy dose and reduces patients’ quality of life. As a safe and convenient intervention, cryotherapy has been recommended as a promising intervention in the recent clinical guidelines for the prevention of TIPN. Although there are a considerable number of studies which explored the use of cryotherapy in preventing chemotherapy-induced peripheral neuropathy (CIPN), there is insufficient large-scale clinical evidence. We performed a meta-analysis on the current available evidence to examine whether cryotherapy can prevent TIPN in cancer patients receiving taxanes.

Methods

We searched databases including PubMed, Embase, and Cochrane from inception to August 3, 2021 for eligible trials. Clinical trials that examined the efficacy of cryotherapy for prevention of TIPN were included. The primary outcome was the incidence of TIPN, and secondary outcomes were incidence of taxane dose reduction and changes in nerve conduction studies. The meta-analysis software (RevMan 5.3) was used to analyze the data.

Results

We analyzed 2250 patients from 9 trials. Assessments using the Common Terminology Criteria for Adverse Events (CTCAE) score showed that cryotherapy could significantly reduce the incidence of motor and sensory neuropathy of grade≥2 (sensory: RR 0.65, 95%CI 0.56 to 0.75, p<0.00001; motor: RR 0.18, 95% CI [0.03, 0.94], p=0.04). When evaluated using the Patient Neuropathy Questionnaire (PNQ), cryotherapy demonstrated significant reduction in the incidence of sensory neuropathy (RR 0.11, 95% CI 0.04 to 0.31], p<0.0001), but did not show significant reduction in the incidence of motor neuropathy (RR 0.46, 95% CI 0.11 to 1.88, p=0.28). Cryotherapy was associated with reduced incidences of taxane dose reduction due to TIPN (RR 0.48, 95% CI [0.24, 0.95], p=0.04) and had potential to preserve motor nerves.

Conclusions

Cryotherapy is likely to prevent TIPN in patients receiving taxanes. High quality and sufficient amount of evidence is warranted.
Multi-Institutional Study Validates Safety of Intraoperative Cesium-131 Brachytherapy for Treatment of Recurrent Head and Neck Cancer
Authors: Luginbuhl Adam , Calder Alyssa , Kutler David , Zender Chad , Wise-Draper Trisha , Patel Jena , Cheng Michael , Karivedu Vidhya , Zhan Tingting , Parashar Bhupesh , Gulati Shuchi , Yao Min , Lavertu Pierre , Takiar Vinita , Tang Alice , Johnson Jennifer , Keane William , Curry Joseph , Cognetti David , Bar-Ad Voichita
Published: December 2021

Introduction

Surgery is the primary treatment for resectable, non-metastatic recurrent head and neck squamous cell carcinoma (HNSCC). We explore the safety and oncologic benefit of intraoperative Cesium-131 (Cs-131) brachytherapy combined with salvage local and/or regional surgical resection.

Methods and Materials

Findings were reported from a single arm multi-institutional prospective phase 1/2 trial involving surgery plus Cs-131 (surgery + Cs-131) treatment. The results of two retrospective cohorts—surgery alone and surgery plus intensity modulated radiation therapy (surgery + ReIMRT)—were also described. Included patients had recurrent HNSCC and radiation history. Safety, tumor re-occurrence, and survival were evaluated.

Results

Forty-nine patients were enrolled in the surgery + Cs-131 prospective study. Grade 1 to 3 adverse events (AEs) occurred in 18 patients (37%), and grade 4 AEs occurred in 2 patients. Postoperative percutaneous endoscopic gastrostomy (PEG) tubes were needed in 10 surgery + Cs-131 patients (20%), and wound and vascular complications were observed in 12 patients (24%). No cases of osteoradionecrosis were reported in the surgery + Cs-131 cohort. We found a 49% 2-year disease-free survival at the site of treatment with a substantial number of patients (31%) developing metastatic disease, which led to a 31% overall survival at 5 years.

Conclusions

Among patients with local/regional recurrent HNSCC status-post radiation, surgery + Cs-131 demonstrated acceptable safety with compelling oncologic outcomes, as compared to historic control cohorts.

Clinical Trial Registration

ClinicalTrials.gov, identifiers NCT02794675 and NCT02467738.
Biology and Treatment of High-Risk CLL: Significance of Complex Karyotype
Authors: Chatzikonstantinou Thomas , Demosthenous Christos , Baliakas Panagiotis
Published: December 2021

Several reports highlight the clinical significance of cytogenetic complexity, namely, complex karyotype (CK) identified though the performance of chromosome banding analysis (CBA) in chronic lymphocytic leukemia. Indeed, apart from a number of studies underscoring the prognostic and predictive value of CK in the chemo(immune)therapy era, mounting evidence suggests that CK could serve as an independent prognosticator and predictor even in patients treated with novel agents. In the present review, we provide an overview of the current knowledge regarding the clinical impact of CK in CLL, touching upon open issues related to the incorporation of CK in the clinical setting.
Effect of a Low-Dose/High-Frequency Training in Introducing a Nurse-Led Neonatal Advanced Life Support Service in a Referral Hospital in Ethiopia
Authors: Tadesse Misrak , Hally Suzanne , Rent Sharla , Platt Phillip L. , Eusterbrock Thomas , Gezahegn Wendmagegn , Kifle Tsinat , Kukora Stephanie , Pollack Louis D.
Published: December 2021

Background and Objective: In Ethiopia, birth asphyxia causes ~30% of all neonatal deaths and 11–31% of deaths among neonates delivered in healthcare facilities that have breathing difficulty at birth. This study aimed to examine the impact of low-dose, high-frequency (LDHF) training for introducing a nurse-led neonatal advanced life support (NALS) service in a tertiary care hospital in Ethiopia.

Methods: Through a retrospective cohort study, a total of 12,001 neonates born post-implementation of the NALS service (between June 2017 and March 2019) were compared to 2,066 neonates born before its implementation (between June 2016 and September 2016). Based on when the neonates were born, they were divided into six groups (groups A to F). All deliveries occurred in the inpatient Labor and Delivery Unit (LDU) at St. Paul's Hospital Millennium Medical College. The number of neonatal deaths in the LDU, neonatal intensive care unit (NICU) admission rate, and proportion of neonates with normal axillary temperature (36.5–37.5°C) within the first hour of life were evaluated. Data were analyzed using the χ2 test, and p-values < 0.05 were considered statistically significant. Following the implementation of the NALS service, semi-structured interviews with key stakeholders were conducted to evaluate their perception of the service; the interviews were recorded, transcribed, and coded for thematic analysis.

Results: There was a decrease in the proportion of neonates who died in the LDU (from 3.5 to 1%) during the immediate post-implementation period, followed by a sustained decrease over the study period (p < 0.001). The change in the NICU admission rate (from 22.8 to 21.2%) was insignificant (p = 0.6) during this initial period. However, this was followed by a significant sustained decrease (7.8% in group E and 9.8% in group F, p < 0.001). The proportion of newborns with normal axillary temperature improved from 46.2% during the initial post-implementation period to 87.8% (p < 0.01); this proportion further increased to 99.8%. The program was perceived positively by NALS team members, NICU care providers, and hospital administrators.

Conclusion: In resource-limited settings, LDHF training for neonatal resuscitation improves the neonatal resuscitation skills and management of delivery room attendants.
Case Report: Neonatal Massive Pneumothorax Resulting in Compression Atelectasis Treated by Ultrasound-Guided Pleural Puncture Therapy: A Typical Case Based on Lung Ultrasound Finding
Authors: Liu Jing , Qiu Ru-Xin , Liu Ying
Published: December 2021

Atelectasis is a complication of different pulmonary diseases; however, neonatal compression atelectasis due to pneumothorax is rarely reported in the literature. Recently, we encountered a typical case of atelectasis. A preterm infant was admitted to the neonatal intensive care unit owing to severe respiratory distress. Lung ultrasound examination confirmed severe pneumothorax and large area of atelectasis. Lung re-expansion occurred when the air was drained from the pleural cavity.
Deprescribing Antipsychotics Based on Real-World Evidence to Inform Clinical Practice: Safety Considerations in Managing Older Adults with Dementia
Authors: Hsieh Stephanie , Yuan Jing , Lu Z. Kevin , Li Minghui
Published: December 2021

Background: Antipsychotics are commonly used in dementia patients but have potential risks that often outweigh clinical benefits. Limited studies have assessed the healthcare utilization and medical costs associated with antipsychotic use, especially those focused on cumulative days of use.

Objectives: To examine clinical and economic burdens associated with different cumulative days of antipsychotic use in older adults with dementia in the United States.

Methods: This study used Medicare Current Beneficiary Survey (2015–2017). Older (≥65 years) Medicare beneficiaries with dementia, without concurrent schizophrenia, bipolar disorder, Huntingon’s disease, or Tourette’s syndrome were included. Antipsychotic use was measured using Medicare Part D prescription events. Healthcare utilization was measured as inpatient services, outpatient services, and emergency room (ER) visits. Total medical costs were classified as Medicare and out-of-pocket costs. The logistic regression, negative binomial regression, and generalized linear model with a log link and gamma distribution were used to examine factors, healthcare utilization, and medical costs. Survey sampling weights were applied to generate national estimates.

Results: Among older adults with dementia, 13.18% used antipsychotics. Factors associated with antipsychotic use were being Hispanic (OR: 2.90; 95% CI: 1.45, 5.78), widowed (OR: 3.52; 95% CI: 1.46, 8.48), and single (OR: 3.25; 95% CI: 1.53, 6.87). Compared to non-users, antipsychotic use was associated with higher inpatient visits (IRR: 2.11; 95% CI 1.53, 2.90), ER visits (IRR: 1.61; 95% CI: 1.21, 2.13), total costs (β: 0.53; 95% CI: 0.36, 0.71), Medicare costs (β: 0.49; 95% CI 0.26, 0.72), and out-of-pocket costs (β: 0.66; 95% CI: 0.35, 0.97). With the increase in cumulative days of antipsychotic use, the magnitude of clinical and economic burdens was decreased.

Conclusion: The significant clinical and economic burdens associated with antipsychotic use, especially with short-term use, provide real-world evidence to inform clinical practice on deprescribing antipsychotics among community-dwelling geriatric dementia patients.
The PI3K Inhibitor XH30 Enhances Response to Temozolomide in Drug-Resistant Glioblastoma via the Noncanonical Hedgehog Signaling Pathway
Authors: Ji Ming , Zhang Zhihui , Lin Songwen , Wang Chunyang , Jin Jing , Xue Nina , Xu Heng , Chen Xiaoguang
Published: December 2021

Glioblastoma multiforme (GBM) is the most common malignant tumor of the central nervous system. Temozolomide (TMZ)–based adjuvant treatment has improved overall survival, but clinical outcomes remain poor; TMZ resistance is one of the main reasons for this. Here, we report a new phosphatidylinositide 3-kinase inhibitor, XH30; this study aimed to assess the antitumor activity of this compound against TMZ-resistant GBM. XH30 inhibited cell proliferation in TMZ-resistant GBM cells (U251/TMZ and T98G) and induced cell cycle arrest in the G1 phase. In an orthotopic mouse model, XH30 suppressed TMZ-resistant tumor growth. XH30 was also shown to enhance TMZ cytotoxicity both in vitro and in vivo. Mechanistically, the synergistic effect of XH30 may be attributed to its repression of the key transcription factor GLI1 via the noncanonical hedgehog signaling pathway. XH30 reversed sonic hedgehog–triggered GLI1 activation and decreased GLI1 activation by insulin-like growth factor 1 via the noncanonical hedgehog signaling pathway. These results indicate that XH30 may represent a novel therapeutic option for TMZ-resistant GBM.
Sempervirine Mediates Autophagy and Apoptosis via the Akt/mTOR Signaling Pathways in Glioma Cells
Authors: Li Gaopan , Zhong Yuhuan , Wang Wenyi , Jia Xiaokang , Zhu Huaichang , Jiang Wenwen , Song Yu , Xu Wen , Wu Shuisheng
Published: December 2021

The potential antitumor effects of sempervirine (SPV), an alkaloid compound derived from the traditional Chinese medicine Gelsemium elegans Benth., on different malignant tumors were described in detail. The impact of SPV on glioma cells and the basic atomic components remain uncertain. This study aimed to investigate the activity of SPV in vitro and in vivo. The effect of SPV on the growth of human glioma cells was determined to explore three aspects, namely, cell cycle, cell apoptosis, and autophagy. In this study, glioma cells, U251 and U87 cells, and one animal model were used. Cells were treated with SPV (0, 1, 4, and 8 μM) for 48 h. The cell viability, cell cycle, apoptosis rate and autophagic flux were examined. Cell cycle, apoptotic, autophagy, and Akt/mTOR signal pathway-related proteins, such as CDK1, Cyclin B1, Beclin-1, p62, LC3, AKT, and mTOR were investigated by Western blot approach. As a result, cells induced by SPV led to G2/M phase arrest and apoptosis. SPV also promoted the effect of autophagic flux and accumulation of LC3B. SPV reduced the expression of p62 protein and induced the autophagic death of glioma cells. Furthermore, SPV downregulated the expressions of AKT and mTOR phosphorylated proteins in the mTOR signaling pathway, thereby affecting the onset of apoptosis and autophagy in U251 cells. In conclusion, SPV induced cellular G2/M phase arrest and blockade of the Akt/mTOR signaling pathway, thereby triggering apoptosis and cellular autophagy. The in vivo and in vitro studies confirmed that SPV inhibits the growth of glioma cancer.
Veratrilla baillonii Franch Ameliorates Diabetic Liver Injury by Alleviating Insulin Resistance in Rats
Authors: Zhang Zhi-Hao , Li Juan , Li Jun , Ma Zhaowu , Huang Xian-Ju
Published: December 2021

Type 2 diabetes mellitus (T2DM) is a complex and polygenic disorder with diverse complications. Veratrilla baillonii Franch (V. baillonii) has been applied in the intervention and treatment a diverse range of diseases, including diabetes. In this study, we revealed that water extracts of V. baillonii (WVBF) can ameliorate liver injury and insulin resistance in T2DM rat model. To elucidate the anti-diabetic mechanisms of WVBF, we performed liver transcriptome analysis that displayed WVBF treatment significantly suppressed many gene expressions involved in insulin resistance. Furthermore, functional experiments showed that WVBF treatment reduced the pathological damages of liver and pancreas, which may be regulated by Foxo1, Sirt1, G6pc, c-Met, Irs1, Akt1, Pik3r1. These results indicated that WVBF improves diabetic liver injury and insulin resistance in diabetic rats. Therefore, this study demonstrated WVBF could be used as a promising therapeutic agent for intervention and treatment of diabetes.
Effectiveness of Medicinal Plants for Glycaemic Control in Type 2 Diabetes: An Overview of Meta-Analyses of Clinical Trials
Authors: Willcox Merlin L. , Elugbaju Christina , Al-Anbaki Marwah , Lown Mark , Graz Bertrand
Published: December 2021

Aims: To rank the effectiveness of medicinal plants for glycaemic control in Type 2 Diabetes (T2DM).

Methods: MEDLINE, EMBASE, CINAHL and Cochrane Central were searched in October 2020. We included meta-analyses of randomised controlled clinical trials measuring the effectiveness of medicinal plants on HbA1c and/or Fasting Plasma Glucose (FPG) in patients with T2DM.

Results: Twenty five meta-analyses reported the effects of 18 plant-based remedies. Aloe vera leaf gel, Psyllium fibre and Fenugreek seeds had the largest effects on HbA1c: mean difference –0.99% [95% CI−1.75, −0.23], −0.97% [95% CI −1.94, −0.01] and −0.85% [95% CI −1.49, −0.22] respectively. Four other remedies reduced HbA1c by at least 0.5%: Nigellasativa, Astragalus membranaceus, and the traditional Chinese formulae Jinqi Jiangtang and Gegen Qinlian. No serious adverse effects were reported. Several other herbal medicines significantly reduced FPG. Tea and tea extracts (Camellia sinensis) were ineffective. However, in some trials duration of follow-up was insufficient to measure the full effect on HbA1c (<8 weeks). Many herbal remedies had not been evaluated in a meta-analysis.

Conclusion: Several medicinal plants appear to be as effective as conventional antidiabetic treatments for reducing HbA1c. Rigorous trials with at least 3 months’ follow-up are needed to ascertain the effects of promising plant-based preparations on diabetes.
Pterostilbene Alleviates Cholestasis by Promoting SIRT1 Activity in Hepatocytes and Macrophages
Authors: Ma Chuanrui , Xiang Jiaqing , Huang Guixiao , Zhao Yaxi , Wang Xinyu , Wu Han , Jiang Kewei , Liang Zhen , Kang Lin , Yang Guangyan , Yang Shu
Published: December 2021

Background and purpose: FXR is a promising target for the treatment of human cholestatic liver disease (CLD). SIRT1 is a deacetylase which promotes FXR activity through deacetylating FXR. Pterostilbene (PTE) is an activator of SIRT1. However, the role of PTE in cholestasis has so far not been investigated. We examined whether PTE treatment alleviate liver injury in DDC or ANIT-induced experimental cholestasis, and explored the underlying mechanisms.

Experimental approach: Mice with DDC- or ANIT-induced cholestasis were treated with different dose of PTE. Primary hepatocytes and bone marrow derived macrophages were used in vitro to assess the molecular mechanism by which PTE may improve CLD. Identical doses of UDCA or PTE were administered to DDC- or ANIT-induced cholestasis mice.

Key results: PTE intervention attenuated DDC or ANIT-induced cholestasis. PTE inhibited macrophage infiltration and activation in mouse liver through the SIRT1-p53 signaling pathway, and it improved hepatic bile metabolism through the SIRT1-FXR signaling pathway. Compare with UDCA, the same doses of PTE was more effective in improving cholestatic liver injury caused by DDC or ANIT.

Conclusion and implications: SIRT1 activation in macrophages may be an effective CLD treatment avenue. Using CLD models, we thus identified PTE as a novel clinical candidate compound for the treatment of CLD.
Adversarial Machine Learning on Social Network: A Survey
Authors: Guo Sensen , Li Xiaoyu , Mu Zhiying
Published: December 2021

In recent years, machine learning technology has made great improvements in social networks applications such as social network recommendation systems, sentiment analysis, and text generation. However, it cannot be ignored that machine learning algorithms are vulnerable to adversarial examples, that is, adding perturbations that are imperceptible to the human eye to the original data can cause machine learning algorithms to make wrong outputs with high probability. This also restricts the widespread use of machine learning algorithms in real life. In this paper, we focus on adversarial machine learning algorithms on social networks in recent years from three aspects: sentiment analysis, recommendation system, and spam detection, We review some typical applications of machine learning algorithms and adversarial example generation and defense algorithms for machine learning algorithms in the above three aspects in recent years. besides, we also analyze the current research progress and prospects for the directions of future research.
Electroacupuncture Combined With Diet Treatment Has a Therapeutic Effect on Perimenopausal Patients With Abdominal Obesity by Improving the Community Structure of Intestinal Flora
Authors: Sheng Jili , Yang Geyao , Jin Xiaoqing , Si Caijuan , Huang Yuan’an , Luo Zhouxiao , Liu Tao , Zhu Jianfang
Published: December 2021

Background: This study explored the influences of electroacupuncture combined with dietary intervention on the intestinal flora in perimenopausal patients with abdominal obesity by using the 16s rRNA sequencing technology.

Methods: Perimenopausal patients with abdominal obesity were divided into the Electroacupuncture group and the Control group. Patients in the Control group received healthy lifestyle education, while those in the Electroacupuncture group received electroacupuncture combined with dietary intervention. Before and after treatment, the weight, height, waist circumference, hip circumference, waist-height ratio (WHtR), waist to hip ratio (WHR), and body mass index (BMI) of the patients were recorded; the levels of serum triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein cholesterol (HDL-C), fasting insulin (FINS), and fasting blood glucose (FGB) were evaluated; and the abundance, diversity, and species differences of intestinal flora were analyzed using 16s rRNA sequencing technology.

Results: The body weight, waist circumference, hip circumference, BMI, WHR, and WHtR of patients in the Electroacupuncture group after treatment were lower than those before treatment. Compared with the Control group, patients in the Electroacupuncture group after treatment displayed lower waist circumference, WHtR, WHR, TG, and LDL levels as well as species abundance, higher species diversity, and lager species difference in the intestinal flora. Besides, the proportions of Klebsiella and Kosakonia in the intestinal flora of patients in the Electroacupuncture group after treatment were larger than those before treatment.

Conclusion: Electroacupuncture combined with diet treatment generated a therapeutic effect on abdominal obesity in perimenopausal patients by improving the community structure of intestinal flora.
A Reappraisal of Ventilatory Thresholds in Wheelchair Athletes With a Spinal Cord Injury: Do They Really Exist?
Authors: Baumgart Julia Kathrin , Ettema Gertjan , Griggs Katy E. , Goosey-Tolfrey Victoria Louise , Leicht Christof Andreas
Published: December 2021

The ventilatory threshold (VT) separates low- from moderate-intensity exercise, the respiratory compensation point (RCP) moderate- from high-intensity exercise. Both concepts assume breakpoints in respiratory data. However, the objective determination of the VT and RCP using breakpoint models during upper-body modality exercise in wheelchair athletes with spinal cord injury (SCI) has received little attention. Therefore, the aim of this study was to compare the fit of breakpoint models (i.e., two linear regression lines) with continuous no-breakpoint models (i.e., exponential curve/second-order polynomial) to respiratory data obtained during a graded wheelchair exercise test to exhaustion. These fits were compared employing adjusted R2, and blocked bootstrapping was used to derive estimates of a median and 95% confidence intervals (CI). V̇O2-V̇CO2 and V̇E/V̇O2-time data were assessed for the determination of the VT, and V̇CO2-V̇E and V̇E/V̇CO2-time data for the determination of the RCP. Data of 9 wheelchair athletes with tetraplegia and 8 with paraplegia were evaluated. On an overall group-level, there was an overlap in the adjusted R2 median ± 95% CI between the breakpoint and the no-breakpoint models for determining the VT (V̇O2-V̇CO2: 0.991 ± 0.003 vs. 0.990 ± 0.003; V̇E/V̇O2-time: 0.792 ± 0.101 vs. 0.782 ± 0.104, respectively) and RCP (V̇E-V̇CO2: 0.984 ± 0.004 vs. 0.984 ± 0.004; V̇E/V̇CO2-time: 0.729 ± 0.064 vs. 0.691 ± 0.063, respectively), indicating similar model fit. We offer two lines of reasoning: (1) breakpoints in these respiratory data exist but are too subtle to result in a significant difference in adjusted R2 between the investigated breakpoint and no-breakpoint models; (2) breakpoints do not exist, as has been argued previously.
Application of Metabolomics to Identify Potential Biomarkers for the Early Diagnosis of Coronary Heart Disease
Authors: Jiang Huali , Li Li , Chen Weijie , Chen Benfa , Li Heng , Wang Shanhua , Wang Min , Luo Yi
Published: December 2021

Coronary heart disease (CHD) is one of the leading causes of deaths globally. Identification of serum metabolic biomarkers for its early diagnosis is thus much desirable. Serum samples were collected from healthy controls (n = 86) and patients with CHD (n = 166) and subjected to untargeted and targeted metabolomics analyses. Subsequently, potential biomarkers were detected and screened, and a clinical model was developed for diagnosing CHD. Four dysregulated metabolites, namely PC(17:0/0:0), oxyneurine, acetylcarnitine, and isoundecylic acid, were identified. Isoundecylic acid was not found in Human Metabolome Database, so we could not validate differences in its relative abundance levels. Further, the clinical model combining serum oxyneurine, triglyceride, and weight was found to be more robust than that based on PC(17:0/0:0), oxyneurine, and acetylcarnitine (AUC = 0.731 vs. 0.579, sensitivity = 83.0 vs. 75.5%, and specificity = 64.0 vs. 46.5%). Our findings indicated that serum metabolomics is an effective method to identify differential metabolites and that serum oxyneurine, triglyceride, and weight appear to be promising biomarkers for the early diagnosis of CHD.
Sorghum-Phosphate Solubilizers Interactions: Crop Nutrition, Biotic Stress Alleviation, and Yield Optimization
Authors: Rizvi Asfa , Ahmed Bilal , Khan Mohammad Saghir , Umar Shahid , Lee Jintae
Published: December 2021

Sweet sorghum [Sorghum bicolor(L.) Moench] is a highly productive, gluten-free cereal crop plant that can be used as an alternative energy resource, human food, and livestock feed or for biofuel-ethanol production. Phosphate fertilization is a common practice to optimize sorghum yield but because of high cost, environmental hazards, and soil fertility reduction, the use of chemical P fertilizer is discouraged. Due to this, the impetus to search for an inexpensive and eco-friendly microbiome as an alternative to chemical P biofertilizer has been increased. Microbial formulations, especially phosphate solubilizing microbiome (PSM) either alone or in synergism with other rhizobacteria, modify the soil nutrient pool and augment the growth, P nutrition, and yield of sorghum. The use of PSM in sorghum disease management reduces the dependence on pesticides employed to control the phytopathogens damage. The role of PSM in the sorghum cultivation system is, however, relatively unresearched. In this manuscript, the diversity and the strategies adopted by PSM to expedite sorghum yield are reviewed, including the nutritional importance of sorghum in human health and the mechanism of P solubilization by PSM. Also, the impact of solo or composite inoculations of biological enhancers (PSM) with nitrogen fixers or arbuscular mycorrhizal fungi is explained. The approaches employed by PSM to control sorghum phytopathogens are highlighted. The simultaneous bio-enhancing and biocontrol activity of the PS microbiome provides better options for the replacement of chemical P fertilizers and pesticide application in sustainable sorghum production practices.
Negative Shocks and Political Parties’ Territorial Demands: The Institutional Roots of Party Competition
Authors: Amat Francesc , Rodon Toni
Published: December 2021

Why do political parties set an extreme or a more moderate position on the territorial dimension? Despite previous works have paid recent interest on the dynamics of the political competition on the territorial dimension, we know much less about the factors that lead to a centrifugal or a centripetal party competition on the same dimension. In this article, we offer a new way of understanding it: we argue that parties’ policy position on the decentralization continuum not only depends on the level of territorial decentralization, but also on the credibility of the institutional agreement established through the country’s constitutional rigidity. If the original territorial pact does not guarantee that the majority group will have its “hands tied” so that it does not reverse the territorial agreement, political parties will have incentives to adopt more extreme positions on the territorial dimension. We test this argument with a dataset covering around 460 political parties clustered in 28 European countries from 1999 to 2019 and by exploiting the fact that the 2008 economic crisis unleashed a shock on the territorial design. Our results confirm our expectations. We show that both the federal deal and the credibility of the institutional arrangement through constitutional rigidity are necessary conditions to appease parties’ demands on the territorial dimension. Our results have important implications for our understanding of how institutions shape political competition along the territorial dimension.
Horizontal Spatial Metaphor Representation of Social Status in Chinese Culture
Authors: Sun Hongri , Liu Danfeng
Published: December 2021

The mapping relationship between social status and horizontal space (left/right) in Chinese culture has a long history. In order to explore the representation pattern of horizontal spatial metaphor of social status in Chinese culture, this study introduced two direct measurements, implicit relational assessment procedure (IRAP) paradigm, and spatial placement task to evaluate the mapping of social status to horizontal space. A total of 144 Chinese undergraduates participated in the research, wherein they were asked to place certain words indicating social status in either left or right box before or after the IRAP computer test. The results from the two measurements consistently showed that the mode of HIGH SOCIAL STATUS-LEFT and LOW SOCIAL STATUS-RIGHT (HLLR) had an advantage over HIGH SOCIAL STATUS-RIGHT and LOW SOCIAL STATUS-LEFT (HRLL), implying that the representation pattern of horizontal spatial metaphor of social status for the Chinese is HIGH SOCIAL STATUS-LEFT and LOW SOCIAL STATUS-RIGHT. However, the result convergence of the two measurements was not high, which suggests that embodiment effect has multiple characteristics and new specific experimental paradigms should be created to measure it.
Association Between Online Self-Directed Learning Ability and Negative Emotions Among College Students During the COVID-19 Pandemic: A Cross-Sectional Study in Anhui Province, East China
Authors: Chang Wei-wei , Zhang Liu , Wen Li-ying , Su Hong , Jin Yue-long
Published: December 2021

Background: This study investigated the correlation between depression, anxiety, and stress among college students engaged in online learning during the coronavirus disease 2019 (COVID-19) pandemic and self-directed learning (SDL) ability, which could provide a scientific basis for mental health education of the college students.

Methods: A cross-sectional study was conducted among 5,558 students from two universities in Anhui province, East China. The Depression, Anxiety, and Stress Scale-21 (DASS-21) and the Self-directed Learning Ability Scale were used to conduct an online questionnaire survey.

Results: A total of 35.15, 36.32, and 17.24% of college students reported symptoms of depression, anxiety, and stress, respectively. Males and nonmedical students were at higher risks to suffer from depression, anxiety, and stress. In adjusted model, compared with Q1 of self-management ability, the odds ratio (OR) of the Q2, Q3, and Q4 were as follows: 0.635 (0.531–0.759), 0.504 (0.415–0.611), and 0.312 (0.248–0.392) for depression; 0.639 (0.535–0.764), 0.653 (0.540–0.789), and 0.421 (0.338–0.525) for anxiety; and 0.649 (0.523–0.805), 0.579 (0.457–0.733), and 0.482 (0.364–0.637) for stress. For information capability, decrease in risk was even more pronounced: Q2 (0.654, 0.540–0.794), Q3 (0.560, 0.454–0.690), and Q4 (0.233, 0.181–0.301) for depression; Q2 (0.781, 0.646–0.945), Q3 (0.616, 0.501–0.757), and Q4 (0.276, 0.216–0.353) for anxiety; and Q2 (0.444, 0.357–0.553), Q3 (0.454, 0.357–0.578), and Q4 (0.272, 0.202–0.368) for stress. Compared with the Q2 group of cooperation learning ability, cooperation learning ability quartiles were positively associated with depression (Q1: 1.382, 95% CI: 1.138–1.678), anxiety (Q4: 1.260, 95% CI: 1.008–1.576), and stress (Q1: 2.002, 95% CI: 1.583–2.532; Q3: 1.600, 95% CI: 1.252–2.044; Q4: 1.674, 95% CI: 1.243–2.255).

Conclusion: The prevalence of depression, anxiety, and stress among college students was high for those studying online at home during the COVID-19 pandemic, especially among nonmedical students and males. SDL ability was negatively associated with negative emotions of the college students during this period of online learning.
Development and Validation of Prediction Formula of Wingate Test Peak Power From Force–Velocity Test in Male Soccer Players
Authors: Nikolaidis Pantelis T. , Knechtle Beat
Published: December 2021

Peak power of the Wingate anaerobic test (WAnT), either in W (Ppeak) or in W.kg–1 (rPpeak), has been widely used to evaluate the performance of soccer players; however, its relationship with force–velocity (F-v) test (e.g., whether these tests can be used interchangeably) has received little scientific attention so far. The aim of this work was to develop and validate a prediction equation of Ppeak and rPpeak from F-v characteristics in male soccer players. Participants were 158 adult male soccer players (sport experience 11.4 ± 4.5 years, mean ± standard deviation, approximately five weekly training units, age 22.6 ± 3.9 years, body mass 74.8 ± 7.8 kg, and height 178.3 ± 7.8 cm) who performed both WAnT and F-v test. An experimental (EXP, n = 79) and a control group (CON, n = 79) were used for development and validation, respectively, of the prediction equation of Ppeak and rPpeak from F-v test. In EXP, Ppeak correlated very largely with body mass (r = 0.787), fat-free mass (r = 0.765), largely with maximal power of F-v test (Pmax; r = 0.639), body mass index (r = 0.603), height (r = 0.558), moderately with theoretical maximal force (F0; r = 0.481), percentage of body fat (r = 0.471), fat mass (r = 0.443, p < 0.001); rPpeak correlated with rPmax (largely; r = 0.596, p < 0.001), theoretical maximal velocity (v0; moderately; r = 0.341, p = 0.002), F0 (small magnitude; r = 0.280, p = 0.012), BF (r = −0.230, p = 0.042), and fat mass (r = −0.242, p = 0.032). Ppeak in EXP could be predicted using the formula “44.251 + 7.431 × body mass (kg) + 0.576 × Pmax (W) – 19.512 × F0” (R = 0.912, R2 = 0.833, standard error of estimate (SEE) = 42.616), and rPpeak from “3.148 + 0.218 × rPmax (W.kg–1) + v0 (rpm)” (R = 0.765, R2 = 0.585, SEE = 0.514). Applying these formulas in CON, no bias was observed between the actual and the predicted Ppeak (mean difference 2.5 ± 49.8 W; 95% CI, −8.7, 13.6; p = 0.661) and rPpeak (mean difference 0.05 ± 0.71 W.kg–1; 95% CI, −0.11, 0.21, p = 0.525). These findings provided indirect estimates of Ppeak of the WAnT, especially useful in periods when this test should not be applied considering the fatigue it causes; in this context, the F-v test can be considered as an alternative of exercise testing for estimating the average Ppeak of a group of soccer players rather than for predicting individual scores when the interindividual variation of performance is small.
Spatial Neglect Midline Diagnostics From Virtual Reality and Eye Tracking in a Free-Viewing Environment
Authors: Hougaard Bastian I. , Knoche Hendrik , Jensen Jim , Evald Lars
Published: December 2021

Purpose: Virtual reality (VR) and eye tracking may provide detailed insights into spatial cognition. We hypothesized that virtual reality and eye tracking may be used to assess sub-types of spatial neglect in stroke patients not readily available from conventional assessments.

Method: Eighteen stroke patients with spatial neglect and 16 age and gender matched healthy subjects wearing VR headsets were asked to look around freely in a symmetric 3D museum scene with three pictures. Asymmetry of performance was analyzed to reveal group-level differences and possible neglect sub-types on an individual level.

Results: Four out of six VR and eye tracking measures revealed significant differences between patients and controls in this free-viewing task. Gaze-asymmetry between-pictures (including fixation time and count) and head orientation were most sensitive to spatial neglect behavior on a group level analysis. Gaze-asymmetry and head orientation each identified 10 out of 18 (56%), compared to 12 out of 18 (67%) for the best conventional test. Two neglect patients without deviant performance on conventional measures were captured by the VR and eyetracking measures. On the individual level, five stroke patients revealed deviant gaze-asymmetry within-pictures and six patients revealed deviant eye orientation in either direction that were not captured by the group-level analysis.

Conclusion: This study is a first step in using VR in combination with eye tracking measures as individual differential neglect subtype diagnostics. This may pave the way for more sensitive and elaborate sub-type diagnostics of spatial neglect that may respond differently to various treatment approaches.
Psychological Benefits of a Sport-Based Program for Female Cancer Survivors: The Role of Social Connections
Authors: Durosini Ilaria , Triberti Stefano , Sebri Valeria , Giudice Alice Viola , Guiddi Paolo , Pravettoni Gabriella
Published: December 2021

In the context of sports-based interventions for improving health and quality of life in chronic patients, participants could develop meaningful social relationships that affect their well-being as much as intervention activities. In this study, 80 female cancer survivors participated in a running-based group intervention (2 sessions/week; 1.5 h), while 51 acted as controls. The intervention lasted approximately 5 months. Unfortunately, the length of the intervention was reduced and sport activities were altered by the COVID-19 pandemic and lockdown mid-intervention, while the shared therapy sessions continued online. This possibly altered the results, as anxiety, depression, and physical aspects did not show significant differences between the experimental and control groups after the intervention. Participants reported positive comments on the experience as a whole, especially regarding the positive influence of the newly developed social connections. This was corroborated by significant correlations between group perceived cohesion and anxiety, depression, self-efficacy, and positive experience with the group psychological support. Overall, it is possible to suggest that in the program an important role was played by social connections and support, peer influence and the group experience, preserving positive experiential qualities of the intervention even if it was altered by external circumstances.
Music Lessons for the Study of Affect
Authors: McCrae Robert R.
Published: December 2021

Some accounts of the evolution of music suggest that it emerged from emotionally expressive vocalizations and serves as a necessary counterweight to the cognitive elaboration of language. Thus, emotional expression appears to be intrinsic to the creation and perception of music, and music ought to serve as a model for affect itself. Because music exists as patterns of changes in sound over time, affect should also be seen in patterns of changing feelings. Psychologists have given relatively little attention to these patterns. Results from statistical approaches to the analysis of affect dynamics have so far been modest. Two of the most significant treatments of temporal patterns in affect—sentics and vitality affects have remained outside mainstream emotion research. Analysis of musical structure suggests three phenomena relevant to the temporal form of emotion: affect contours, volitional affects, and affect transitions. I discuss some implications for research on affect and for exploring the evolutionary origins of music and emotions.
Coparenting and Parental Involvement During School Transition Among Chinese Mothers and Fathers: Children’s School Liking as a Moderator
Authors: Tao Sisi , Lau Eva Yi Hung
Published: December 2021

Parental involvement is a vital social resource that helps children to deal with different challenges in their learning and development in the transition period and may be a strong determinant of children’s outcomes. While the role of fathers has been increasingly recognized, there has been a lack of studies examining the predictive role of mother and fathers’ coparenting to parental involvement and child readiness outcomes. The purpose of this study is to examine the longitudinal association between coparenting behavior and parental involvement for parents with children in the transition to primary school in a Chinese context, and test whether children’s school liking moderated these associations. Using stratified random sampling, 324 children (Mage=70.57months, female=51%) and their parents from 10 kindergartens in Hong Kong participated in the study. Both mothers and fathers provided information about their spouse’s coparenting behavior at Time 1 (the final year of kindergarten), and their parental involvement at home and school at Time 1 and 2 (the first year of primary school). Children’s school liking was assessed by puppet interview at Time 1. Results indicated that maternal cooperation was positively associated with paternal involvement at home and in school, and paternal cooperation was positively associated with maternal involvement at home. Children’s school liking moderated the longitudinal associations between coparenting behavior (Time 1) and parental involvement (Time 2). Specifically, mothers of children with high levels of school liking were involved more in school when they perceived more cooperation from the spouse. Fathers of children with low levels of school liking were less involved in school when they perceived more cooperation, while involved more at home and in school when they perceived more triangulation from the spouse. Additionally, fathers perceiving more triangulation decreased their home involvement when the child reported high levels of school liking. Findings of this study revealed that coparenting, children’s school liking, and parental gender might be important to understanding parental involvement during school transition.
Nature Interest Scale – Development and Evaluation of a Measurement Instrument for Individual Interest in Nature
Authors: Kleespies Matthias Winfried , Doderer Lena , Dierkes Paul Wilhelm , Wenzel Volker
Published: December 2021

Interest is an important factor for successful learning that has been the subject of intensive research for decades. Although interest in nature is of great importance for environmental education, to date there is no valid and reliable measurement tool. Therefore, the purpose of this study was to develop and test a scale for interest in nature, the Nature Interest Scale (NIS). In study 1, nine items were selected based on the three dimensions of the psychological interest construct to represent interest in nature. The factor structure of this new measurement instrument, was tested using confirmatory factor analyses. The results show that the instrument represents the three dimensions of the interest construct well. In study 2 the validity (discriminant and convergent validity) as well as the reliability (internal consistency, composite reliability, test-retest reliability) of the NIS were demonstrated. In study 3, the applicability of the NIS was tested with a different target group, students with learning disabilities. The results of this factor analysis also confirm the factor structure of the scale. Thus, this study provides a valid and reliable measurement tool for individual interest in nature that can be used for future research.
Understanding Digital Learning Behaviors: Moderating Roles of Goal Setting Behavior and Social Pressure in Large-Scale Open Online Courses
Authors: Zhang Peng
Published: December 2021

Pandemic has changed the whole scenario worldwide, not only related to business but also has equally affected the education sector. The classes have gone online from their physical nature, making it more convenient for students to learn. They provide online courses and lectures at the convenience of teachers and students. This study has also been one such effort in identifying the role of technological applications, intentions, and time flexibility in the digital learning behavior of students in China. The sample used in this study was the students taking online courses through their universities. The sample size was 343 students selected through purposive sampling. Smart PLS 3.3.3 has been used for data analysisviastructural equation modeling. This study has found that technological applications play an important role in digital learning behavior, positively moderated by goal-setting behavior. Similarly, intentions predict digital learning behavior. Moreover, social pressure has also been found to augment the role of time flexibility in digital learning behavior. These results are very useful for universities that make understanding the online nature of studies more comprehensive.
The Impact of Learning From Failure on New Ventures’ Sustainable Development
Authors: Shirshitskaia Ekaterina , Zhou Xue , Zhang Ling
Published: December 2021

How to absorb failure experiences to achieve reunification and turn crises into opportunities is crucial for enterprises. We examine the effect of learning from failure on new ventures’ sustainable development from the lens of resource orchestration theory. With 193 samples of entrepreneurs in Mainland China, this study provides the first quantitative evidence regarding how learning from failure influences new ventures’ sustainable development through entrepreneurial dynamic capability and strategic decision comprehensiveness. Stepwise regression analysis results show that learning from failure has a positive impact on the entrepreneurial dynamic capability and strategic decision comprehensiveness. Entrepreneurial dynamic capability and strategic decision comprehensiveness positively influence new ventures’ sustainable development, and exert mediating roles between learning from failure and new ventures’ sustainable development.