bluuebunny/crossref_metadata_2025 huggingface dataset:
Antimicrobial Dosing Recommendations in Pediatric Continuous Renal Replacement Therapy: A Critical Appraisal of Current Evidence
Authors: Stitt Gideon , Dubinsky Samuel , Edginton Andrea , Huang Yuan-Shung V. , Zuppa Athena F. , Watt Kevin , Downes Kevin
Published: May 2022

Objectives

Continuous renal replacement therapy (CRRT) is commonly employed in critically ill children and is known to affect antimicrobial pharmacokinetics. There is a lack of readily available, evidence-based antimicrobial dosing recommendations in pediatric CRRT. This study aims to quantify commonly used antimicrobial drugs in pediatric CRRT and identify gaps between contemporary literature-based dosing recommendations and those presented in a frequently used dosing reference.

Methods

The Pediatric Health Information System (PHIS) database was queried from July 1, 2018 through June 30, 2021 to identify admissions in which antimicrobials were billed on the same day as CRRT. Drugs of interest were selected if at least 10% of admission involved administration on at least one CRRT day, with additional clinically important antimicrobials selected by the authors. A comprehensive literature search was performed to identify antimicrobial pharmacokinetic (PK) studies in children for each selected drug. For identified articles, dosing recommendations were extracted and compared to those in a popular tertiary dosing reference (Lexi-Comp Online database). The level of agreement of the dosing recommendations was assessed.

Results

77 unique antimicrobial agents were identified amongst 812 admissions from 20 different PHIS hospitals. Fifteen antimicrobials were billed on the same day as CRRT in ≥10% of admissions, with 4 additional drugs deemed clinically relevant by the authors. Twenty PK studies were identified for these 19 drugs, and dosing recommendations were included in 8 (42.1%) of them. Seventeen agents (89.5%) had some type of CRRT-specific dosing guidance in Lexi-Comp, with only 1 directly based on a pediatric CRRT study. For the 8 agents with PK data available, Lexi-Comp recommendations matched primary literature dosing guidance in 3 (37.5%). Two (25%) lacked agreement between the Lexi-Comp and primary literature, and the remaining 3 (37.5%) had partial agreement with multiple dosing regimens suggested in the primary literature and at least one of these regimens recommended by Lexi-Comp.

Conclusion

Significant gaps exist in the data supporting antimicrobial dosing recommendations for children receiving CRRT. Future studies should focus on antimicrobial dosing in pediatric CRRT, emphasizing provision of robust data from which dosing recommendations can be promptly incorporated into tertiary dosing references.
Role of Phytochemicals in Skin Photoprotection via Regulation of Nrf2
Authors: Chaiprasongsuk Anyamanee , Panich Uraiwan
Published: May 2022

Ethnopharmacological studies have become increasingly valuable in the development of botanical products and their bioactive phytochemicals as novel and effective preventive and therapeutic strategies for various diseases including skin photoaging and photodamage-related skin problems including abnormal pigmentation and inflammation. Exploring the roles of phytochemicals in mitigating ultraviolet radiation (UVR)-induced skin damage is thus of importance to offer insights into medicinal and ethnopharmacological potential for development of novel and effective photoprotective agents. UVR plays a role in the skin premature aging (or photoaging) or impaired skin integrity and function through triggering various biological responses of skin cells including apoptosis, oxidative stress, DNA damage and inflammation. In addition, melanin produced by epidermal melanocytes play a protective role against UVR-induced skin damage and therefore hyperpigmentation mediated by UV irradiation could reflect a sign of defensive response of the skin to stress. However, alteration in melanin synthesis may be implicated in skin damage, particularly in individuals with fair skin. Oxidative stress induced by UVR contributes to the process of skin aging and inflammation through the activation of related signaling pathways such as the mitogen-activated protein kinase (MAPK)/activator protein-1 (AP-1), the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt), the nuclear factor kappa B (NF-κB) and the signal transducer and activator of transcription (STAT) in epidermal keratinocytes and dermal fibroblasts. ROS formation induced by UVR also plays a role in regulation of melanogenesis in melanocytes via modulating MAPK, PI3K/Akt and the melanocortin 1 receptor (MC1R)-microphthalmia-associated transcription factor (MITF) signaling cascades. Additionally, nuclear factor erythroid 2-related factor 2 (Nrf2)-regulated antioxidant defenses can affect the major signaling pathways involved in regulation of photoaging, inflammation associated with skin barrier dysfunction and melanogenesis. This review thus highlights the roles of phytochemicals potentially acting as Nrf2 inducers in improving photoaging, inflammation and hyperpigmentation via regulation of cellular homeostasis involved in skin integrity and function. Taken together, understanding the role of phytochemicals targeting Nrf2 in photoprotection could provide an insight into potential development of natural products as a promising strategy to delay skin photoaging and improve skin conditions.
An Imidazoline 2 Receptor Ligand Relaxes Mouse Aorta via Off-Target Mechanisms Resistant to Aging
Authors: Jiménez-Altayó Francesc , Cabrera Anna , Bagán Andrea , Giménez-Llort Lydia , D’Ocon Pilar , Pérez Belén , Pallàs Mercè , Escolano Carmen
Published: May 2022

Imidazoline receptors (IR) are classified into three receptor subtypes (I1R, I2R, and I3R) and previous studies showed that regulation of I2R signaling has neuroprotective potential. In order to know if I2R has a role in modulating vascular tone in health and disease, we evaluated the putative vasoactive effects of two recently synthesized I2R ligands, diethyl (1RS,3aSR,6aSR)-5-(3-chloro-4-fluorophenyl)-4,6-dioxo-1-phenyl-1,3a,4,5,6,6a-hexahydropyrrolo[3,4-c]pyrrole -1-phosphonate (B06) and diethyl [(1-(3-chloro-4-fluorobenzyl)-5,5-dimethyl-4-phenyl-4,5-dihydro-1H-imidazol-4-yl]phosphonate] (MCR5). Thoracic aortas from Oncins France 1 (3- to 4-months-old) and C57BL/6 (3- to 4- and 16- to 17-months-old mice) were mounted in tissue baths to measure isometric tension. In young mice of both strains, MCR5 induced greater relaxations than either B06 or the high-affinity I2R selective ligand 2-(2-benzofuranyl)-2-imidazoline (2-BFI), which evoked marginal responses. MCR5 relaxations were independent of I2R, as IR ligands did not significantly affect them, involved activation of smooth muscle KATP channels and inhibition of L-type voltage-gated Ca2+ channels, and were only slightly modulated by endothelium-derived nitric oxide (negatively) and prostacyclin (positively). Notably, despite the presence of endothelial dysfunction in old mice, MCR5 relaxations were preserved. In conclusion, the present study provides evidence against a functional contribution of I2R in the modulation of vascular tone in the mouse aorta. Moreover, the I2R ligand MCR5 is an endothelium-independent vasodilator that acts largely via I2R-independent pathways and is resistant to aging. We propose MCR5 as a candidate drug for the management of vascular disease in the elderly.
Dihydroquercetin Attenuates Silica-Induced Pulmonary Fibrosis by Inhibiting Ferroptosis Signaling Pathway
Authors: Yuan Leyong , Sun Yan , Zhou Ning , Wu Weipeng , Zheng Weidong , Wang Yukun
Published: May 2022

Silicosis is a fatal occupational lung disease which currently has no effective treatment. Dihydroquercetin (DHQ) is a flavonoid compound known for its anti-inflammatory, anti-oxidant and anti-cancer bioactivity. However, whether DHQ protects against silica-induced lung fibrosis remains unknown. Therefore, we aimed to investigate the effect of DHQ on silica-induced lung fibrosis and the underlying molecular mechanism in vivo and in vitro. Our results demonstrated that DHQ treatment markedly attenuated SiO2-induced inflammation and fibrosis degree of lung tissues in the C57BL/6 mice. Additionally, experiments in vitro also confirmed that conditioned medium from DHQ-treated human bronchial epithelial (HBE) cells significantly decreased expression of fibrosis markers of human fetal lung fibroblast cells (MRC-5), such as α-SMA, collagen1 and fibronectin. Interestingly, HBE cells treated by DHQ showed few morphological features of ferroptosis compared with SiO2-treated cells. Furthermore, DHQ treatment remarkably inhibited ferroptosis in activated HBE cells by decreasing the accumulation of iron and lipid peroxidation products, and increasing levels of glutathione (GSH) and glutathione peroxidase 4 (GPX4), whereas stimulation of ferroptosis by specific inducer erastin deeply impaired anti-fibrosis effect of DHQ in vitro. More importantly, our results showed that DHQ also evidently suppressed ferritinophagy by down-regulation of microtubule-associated protein 1A/1B-light chain 3 (LC3), and up-regulation of ferritin heavy chain 1 (FTH1), nuclear receptor co-activator 4 (NCOA4) in activated HBE cells. Nevertheless, activation of ferritinophagy by specific inducer rapamycin (Rapa) evidently blocked DHQ-inhibited HBE cells ferritinophagy and anti-fibrosis effect of DHQ. Overall, our research revealed that inhibition of ferritinophagy-mediated HBE cells ferroptosis was responsible for DHQ to ameliorate SiO2-induced lung fibrosis, which provided a preliminary theoretical basis for the clinical application of DHQ in the treatment of silicosis.
Application of Physiologically Based Pharmacokinetic Modeling in Preclinical Studies: A Feasible Strategy to Practice the Principles of 3Rs
Authors: Yuan Yawen , He Qingfeng , Zhang Shunguo , Li Min , Tang Zhijia , Zhu Xiao , Jiao Zheng , Cai Weimin , Xiang Xiaoqiang
Published: May 2022

Pharmacokinetic characterization plays a vital role in drug discovery and development. Although involving numerous laboratory animals with error-prone, labor-intensive, and time-consuming procedures, pharmacokinetic profiling is still irreplaceable in preclinical studies. With physiologically based pharmacokinetic (PBPK) modeling, the in vivo profiles of drug absorption, distribution, metabolism, and excretion can be predicted. To evaluate the application of such an approach in preclinical investigations, the plasma pharmacokinetic profiles of seven commonly used probe substrates of microsomal enzymes, including phenacetin, tolbutamide, omeprazole, metoprolol, chlorzoxazone, nifedipine, and baicalein, were predicted in rats using bottom-up PBPK models built with in vitro data alone. The prediction’s reliability was assessed by comparison with in vivo pharmacokinetic data reported in the literature. The overall predicted accuracy of PBPK models was good with most fold errors within 2, and the coefficient of determination (R2) between the predicted concentration data and the observed ones was more than 0.8. Moreover, most of the observation dots were within the prediction span of the sensitivity analysis. We conclude that PBPK modeling with acceptable accuracy may be incorporated into preclinical studies to refine in vivo investigations, and PBPK modeling is a feasible strategy to practice the principles of 3Rs.
Formononetin Attenuates Renal Tubular Injury and Mitochondrial Damage in Diabetic Nephropathy Partly via Regulating Sirt1/PGC-1α Pathway
Authors: Huang Qunwei , Chen Hongbo , Yin Kai , Shen Yilan , Lin Kanghong , Guo Xieyi , Zhang Xiang , Wang Niansong , Xin Wenfeng , Xu Youhua , Gui Dingkun
Published: May 2022

Mitochondrial abnormality is one of the main factors of tubular injury in diabetic nephropathy (DN). Formononetin (FMN), a novel isoflavonoid isolated from Astragalus membranaceus, has diverse pharmacological activities. However, the beneficial effects of FMN on renal tubular impairment and mitochondrial dysfunction in DN have yet to be studied. In this study, we performed in vivo tests in Streptozotocin (STZ) -induced diabetic rats to explore the therapeutic effects of FMN on DN. We demonstrated that FMN could ameliorate albuminuria and renal histopathology. FMN attenuated renal tubular cells apoptosis, mitochondrial fragmentation and restored expression of mitochondrial dynamics-associated proteins, such as Drp1, Fis1 and Mfn2, as well as apoptosis-related proteins, such as Bax, Bcl-2 and cleaved-caspase-3. Moreover, FMN upregulated the protein expression of Sirt1 and PGC-1α in diabetic kidneys. In vitro studies further demonstrated that FMN could inhibit high glucose-induced apoptosis of HK-2 cells. FMN also reduced the production of mitochondrial superoxide and alleviated mitochondrial membrane potential (MMP) loss. Furthermore, FMN partially restored the protein expression of Drp1, Fis1 and Mfn2, Bax, Bcl-2, cleaved-caspase-3, Sirt1 and PGC-1α in HK-2 cells exposure to high glucose. In conclusion, FMN could attenuate renal tubular injury and mitochondrial damage in DN partly by regulating Sirt1/PGC-1α pathway.
Acoustic Radiation Force and Torque Acting on Asymmetric Objects in Acoustic Bessel Beam of Zeroth Order Within Rayleigh Scattering Limit
Authors: Sepehrirahnama Shahrokh , Oberst Sebastian
Published: May 2022

Acoustic momentum exchange between objects and the surrounding fluid can be quantified in terms of acoustic radiation force and torque, and depends on several factors including the objects’ geometries. For a one-dimensional plane wave type, the induced torque on the objects with arbitrary shape becomes a function of both, direct polarization and Willis coupling, as a result of shape asymmetry, and has only in-plane components. Here, we investigate, in the Rayleigh scattering limit, the momentum transfer to objects in the non-planar pressure field of an acoustic Bessel beam with axisymmetric wave front. This type of beam is selected since it can be practically realized by an array of transducers that are cylindrically arranged and tilted at the cone angle β which is a proportionality index of the momentum distribution in the transverse and axial propagation directions. The analytical expressions of the radiation force and torque are derived for both symmetric and asymmetric objects. We show the dependence of radiation force and torque on the characteristic parameters β and radial distance from the beam axis. By comparing against the case of a plane travelling plane wave, zero β angle, we demonstrated that the non-planar wavefront of a zeroth order Bessel beam causes an additional radial force and axial torque. We also show that, due to Willis coupling, an asymmetric object experiences greater torques in the θ direction, by minimum of one order of magnitude compared to a plane travelling wave. Further, the components of the partial torques owing to direct polarization and Willis coupling act in the same direction, except for a certain range of cone angle β. Our findings show that a non-planar wavefront, which is quantified by β in the case of a zeroth-order Bessel beam, can be used to control the magnitude and direction of the acoustic radiation force and torque acting on arbitrarily shaped objects, implying that the wavefront should be adjusted according to the object’s shape to impart acoustic momentum in all directions and achieve a desired acoustophoretic response.
Evaluation Method of Basketball Teaching and Training Effect Based on Wearable Device
Authors: Li Shuai , Zhang Wei
Published: May 2022

To reduce errors in the evaluation of basketball players’ training effect and facilitate the coaches to make reasonable training plans, this study proposes an evaluation method of the basketball player training effect based on wearable devices and machine learning algorithms. Wearable devices in social physics are intelligent, and their main components are integrated into clothing and other accessories. They collect data, track activities, and customize the experience to the needs and desires of users. In this study, physiological indicators such as heart rate and hemoglobin are selected as input vectors of the support vector machine (SVM), and the expected value of basketball player training effect evaluation is taken as the output to construct training samples. The parameters of the SVM are set to minimize the evaluation error as the learning objective. The SVM learns training samples and constructs an evaluation model for the training effect of basketball players. We use the method proposed in this study to evaluate the training effect of basketball players through computer simulation of dribble, pass, rebound, layup, and shooting. The experimental results show that the training effect evaluation of basketball players with the proposed method has a low relative error, high classification accuracy, and high practical application value.
A Novel Egg-In-Cube System Enables Long-Term Culture and Dynamic Imaging of Early Embryonic Development
Authors: Dave Mohit , Levin Joshua , Ruffins Seth Walter , Sato Yuki , Fraser Scott , Lansford Rusty , Kawahara Tomohiro
Published: May 2022

The avian egg is a closed system that protects the growing embryo from external factors but prevents direct observation of embryo development. Various culture systems exist in the literature to study the development of the embryo for short periods of incubation (from 12 h up to a maximum of 60 h of egg incubation). A common flaw to these culture techniques is the inability to culture the unincubated avian blastoderm with intact tissue tensions on its native yolk. The goal of this work is to create a unique novel egg-in-cube system that can be used for long-term quail embryo culture initiated from its unincubated blastoderm stage. The egg-in-cube acts as an artificial transparent eggshell system that holds the growing embryo, making it amenable to microscopy. With the egg-in-cube system, quail embryos can be grown up to 9 days from the unincubated blastoderm (incubated in air, 20.9% O2), which improves to 15 days on switching to a hyperoxic environment of 60% O2. Using transgenic fluorescent quail embryos in the egg-in-cube system, cell movements in the unincubated blastoderm are imaged dynamically using inverted confocal microscopy, which has been challenging to achieve with other culture systems. Apart from these observations, several other imaging applications of the system are described in this work using transgenic fluorescent quail embryos with upright confocal or epifluorescence microscopy. To demonstrate the usefulness of the egg-in-cube system in perturbation experiments, the quail neural tube is electroporated with fluorescent mRNA “in cubo”, followed by the incubation of the electroporated embryo and microscopy of the electroporated region with the embryo in the cube. The egg-in-cube culture system in combination with the “in cubo” electroporation and dynamic imaging capabilities described here will enable researchers to investigate several fundamental questions in early embryogenesis with the avian (quail) embryo on its native yolk.
Premature Termination Codon of 1Dy12 Gene Improves Cookie Quality in Ningmai9 Wheat
Authors: Liu Guangxiao , Gao Yujiao , Wang Huadun , Wang Yonggang , Chen Jianmin , Zhang Pingping , Ma Hongxiang
Published: May 2022

The area between middle and lower reaches of the Yangtze River is the largest region for soft wheat production in China. In soft wheat breeding, the lack of germplasm with desirable quality for end-use products is a barrier. Ningmai9 is the main variety of soft wheat planted in this area. To create germplasm with better quality and yield potential than Ningmai9, mutants of HMW-GSs in Ningmai9 induced by ethylmethanesulfonate (EMS) were obtained. SDS-PAGE showed that two mutants, md10 and md11, were HMW-GS 1Dy deletions. DNA sequencing confirmed that one mutation was caused by a C/T substitution, resulting in the change of CAA encoding glutamine into the termination codon TAA, and another mutation was due to a G/A substitution in the central repetitive domain of the coding region, causing TGG encoding tryptophan to become the termination codon TGA. The premature termination codon of the 1Dy12 gene affected the expression of 1Dy12 and kept the mRNA at a lower transcription level during the kernel development stage in comparison with the wild type. HMW-GS 1Dy12 deletion mutants decreased the content of HMW-GSs and glutenin macropolymers, mixograph envelope peak time and TIMEX width, water solvent retention capacity (WSRC), and lactic acid solvent retention capacity (LASRC). In the HMW-GS 1Dy12 deletion lines, the sugar-snap cookie diameter was 8.70–8.74 cm, which was significantly larger than that in the wild type of 8.0 cm. There were no significant differences in spike number, kernel number, thousand kernel weight, and yield between the deletion lines and wild type. Overall, the study indicated that the knockout of the HMW-GS gene induced by EMS is an effective way to improve wheat quality, and deletion mutants of HMW-GS 1Dy12 decrease gluten strength and increase sugar snap cookie diameter without yield penalty in Ningmai9 wheat.
Transcriptome Sequence Analysis of the Defense Responses of Resistant and Susceptible Cucumber Strains to Podosphaera xanthii
Authors: Meng Xiangnan , Yu Yongbo , Song Tiefeng , Yu Yang , Cui Na , Ma Zhangtong , Chen Lijie , Fan Haiyan
Published: May 2022

Powdery mildew (PM) caused by Podosphaera xanthii poses a continuous threat to the performance and yield of the cucumber (Cucumis sativus L.). Control in the initial stages of infection is particularly important. Here, we studied the differential physiological and transcriptomic changes between PM-resistant strain B21-a-2-1-2 and PM-susceptible strain B21-a-2-2-2 at the early stage of P. xanthii attack. When challenged with P. xanthii, the tolerant line can postpone the formation of the pathogen primary germ. Comparative transcriptomic analysis suggested that DEGs related to the cell wall and to pathogen and hormone responses were similar enriched in both cucumber lines under P. xanthii infection. Notably, the number of DEGs triggered by P. xanthii in B21-a-2-1-2 was quintuple that in B21-a-2-2-2, revealing that the success of defense of resistant cucumber is due to rapidly mobilizing multiple responses. The unique responses detected were genes related to SA signaling, MAPK signaling, and Dof and WRKY transcription factors. Furthermore, 5 P. xanthii -inducible hub genes were identified, including GLPK, ILK1, EIN2, BCDHβ1, and RGGA, which are considered to be key candidate genes for disease control. This study combined multiple analytical approaches to capture potential molecular players and will provide key resources for developing cucumber cultivars resistant to pathogen stress.
CRISPR/Cas9-Mediated Targeted Mutagenesis of FtMYB45 Promotes Flavonoid Biosynthesis in Tartary Buckwheat (Fagopyrum tataricum)
Authors: Wen Dong , Wu Lan , Wang Mengyue , Yang Wei , Wang Xingwen , Ma Wei , Sun Wei , Chen Shilin , Xiang Li , Shi Yuhua
Published: May 2022

The clustered regularly interspaced short palindromic repeat/CRISPR-associated protein 9 (CRISPR/Cas9) technology is an efficient genome editing tool used in multiple plant species. However, it has not been applied to Tartary buckwheat (Fagopyrum tataricum), which is an important edible and medicinal crop rich in rutin and other flavonoids. FtMYB45 is an R2R3-type MYB transcription factor that negatively regulates flavonoid biosynthesis in Tartary buckwheat. Here, the CRISPR/Cas9 system polycistronic tRNA-sgRNA (PTG)/Cas9 was employed to knock out the FtMYB45 gene in Tartary buckwheat. Two single-guide RNAs (sgRNAs) were designed to target the second exon of the FtMYB45 gene. Twelve transgenic hairy roots were obtained using Agrobacterium rhizogenes-mediated transformation. Sequencing data revealed that six lines containing six types of mutations at the predicted double-stranded break site were generated using sgRNA1. The mutation frequency reached 50%. A liquid chromatography coupled with triple quadrupole mass spectrometry (LC-QqQ-MS) based metabolomic analysis revealed that the content of rutin, catechin, and other flavonoids was increased in hairy root mutants compared with that of lines transformed with the empty vector. Thus, CRISPR/Cas9-mediated targeted mutagenesis of FtMYB45 effectively increased the flavonoids content of Tartary buckwheat. This finding demonstrated that the CRISPR/Cas9 system is an efficient tool for precise genome editing in Tartary buckwheat and lays the foundation for gene function research and quality improvement in Tartary buckwheat.
Fungal Degradation of Extractives Plays an Important Role in the Brown Rot Decay of Scots Pine Heartwood
Authors: Belt Tiina , Harju Anni , Kilpeläinen Petri , Venäläinen Martti
Published: May 2022

Scots pine heartwood is known to have resistance to wood decay due to the presence of extractives, namely stilbenes and resin acids. However, previous studies have indicated that these extractives are degradable by wood decaying fungi. This study aimed to investigate the relationship between extractive degradation and heartwood decay in detail and to gain insight into the mechanisms of extractive degradation. Mass losses recorded after a stacked-sample decay test with brown rot fungi showed that the heartwood had substantial decay resistance against Coniophora puteana but little resistance against Rhodonia placenta. Extracts obtained from the decayed heartwood samples revealed extensive degradation of stilbenes by R. placenta in the early stages of decay and a noticeable but statistically insignificant loss of resin acids. The extracts from R. placenta-degraded samples contained new compounds derived from the degraded extractives: hydroxylated stilbene derivatives appeared in the early decay stages and then disappeared, while compounds tentatively identified as hydroxylated derivatives of dehydroabietic acid accumulated in the later stages. The degradation of extractives was further analysed using simple degradation assays where an extract obtained from intact heartwood was incubated with fungal mycelium or extracellular culture fluid from liquid fungal cultures or with neat Fenton reagent. The assays showed that extractives can be eliminated by several fungal degradative systems and revealed differences between the degradative abilities of the two fungi. The results of the study indicate that extractive degradation plays an important role in heartwood decay and highlight the complexity of the fungal degradative systems.
A Relativistic Theory of Consciousness
Authors: Lahav Nir , Neemeh Zachariah A.
Published: May 2022

In recent decades, the scientific study of consciousness has significantly increased our understanding of this elusive phenomenon. Yet, despite critical development in our understanding of the functional side of consciousness, we still lack a fundamental theory regarding its phenomenal aspect. There is an “explanatory gap” between our scientific knowledge of functional consciousness and its “subjective,” phenomenal aspects, referred to as the “hard problem” of consciousness. The phenomenal aspect of consciousness is the first-person answer to “what it’s like” question, and it has thus far proved recalcitrant to direct scientific investigation. Naturalistic dualists argue that it is composed of a primitive, private, non-reductive element of reality that is independent from the functional and physical aspects of consciousness. Illusionists, on the other hand, argue that it is merely a cognitive illusion, and that all that exists are ultimately physical, non-phenomenal properties. We contend that both the dualist and illusionist positions are flawed because they tacitly assume consciousness to be an absolute property that doesn’t depend on the observer. We develop a conceptual and a mathematical argument for a relativistic theory of consciousness in which a system either has or doesn’t have phenomenal consciousnesswith respect to some observer.Phenomenal consciousness is neither private nor delusional, just relativistic. In the frame of reference of the cognitive system, it will be observable (first-person perspective) and in other frame of reference it will not (third-person perspective). These two cognitive frames of reference are both correct, just as in the case of an observer that claims to be at rest while another will claim that the observer has constant velocity. Given that consciousness is a relativistic phenomenon, neither observer position can be privileged, as they both describe the same underlying reality. Based on relativistic phenomena in physics we developed a mathematical formalization for consciousness which bridges the explanatory gap and dissolves the hard problem. Given that the first-person cognitive frame of reference also offers legitimate observations on consciousness, we conclude by arguing that philosophers can usefully contribute to the science of consciousness by collaborating with neuroscientists to explore the neural basis of phenomenal structures.
Why Do Women Pretend to Be Men? Female Gender Swapping in Online Games
Authors: Zhou Liling , Han Ning , Xu Zeran , Brian Corlyn , Hussain Siraj
Published: May 2022

This research explored the influencing factors of gender swapping among female players in online games and their impact on online gaming behavior. Based on an online survey of 3,658 female players in China, we found that perceived benefits and the Tanbi tendency, a psychological indulgence in enjoying novels, comics, or series on love and sex between attractive males, were the most important factors for female players to employ male avatars. Sexual orientation, perceived anonymity, and perceived tolerance also had a significant influence on gender swapping. Different from the practical benefits perceived by men who use female avatars in online games, the perceived benefit for female players who use male avatars was to avoid gender discrimination. In order to obtain more freedom and fairer treatment, they chose male avatars for a better experience. Female players with a higher degree of gender swapping showed a stronger aggressiveness and dominant “hyper-masculinity” behavior tendency in the game. Though online virtual worlds may be a convenient place for females to experience gender equality through gender swapping, the findings of this study suggest that gender swapping in games may, to some extent, perpetuate or even reinforce gender stereotypes in the real world.
Borderline Pathological Celebrity Worship and Impulsive Buying Intent: Mediating and Moderating Roles of Empathy and Gender
Authors: Chen Outong , Zhao Xiaojing , Ding Dongxing , Zhang Yifan , Zhou Hongbo , Liu Ranran
Published: May 2022

The present study constructed a moderated mediation model to examine whether borderline pathological celebrity worship may be associated with higher levels of impulsive buying intent. The mediating role of empathy and the moderating role of gender were also examined. A total of 1,319 participants recruited from a college through the campus network. The results indicated that (1) borderline pathological celebrity worship could positively predict individuals’ impulsive buying intent; (2) the predictive effect of borderline pathological celebrity worship on impulsive buying intent could be mediated by empathy; and (3) gender moderated the predictive effect of borderline pathological celebrity worship on impulsive buying intent. Specifically, relatively higher levels of borderline pathological celebrity worship were found to be associated with higher impulsive buying intent among men. However, this was relatively less significant among women.

Conclusion

The results contribute to previous findings by demonstrating that borderline pathological celebrity worship could affect impulsive buying intent. Moreover, the mediating role of empathy and the moderating role of gender were also revealed.
The Implication of Digital Organisational Culture on Firm Performance
Authors: Pradana Mahir , Silvianita Anita , Syarifuddin Syarifuddin , Renaldi Renaldi
Published: May 2022

Digital technologies have become a major factor for innovation in the business environment. Organisations have taken advantage of digitised data and information to increase performance. However, there is still little research focusing on the effect of digitalisation on organisational culture, which in the end will affect performance. We develop this research by exploring a proposed model involving digital organisational culture with the final goal to enhance organisational performance. The research involved 263 managers of state-owned companies in Indonesia. We analysed the theoretical model by using structural equation modelling and processed the data using the SmartPLS version 3 software. We conclude that digital organisational culture can become an essential factor in improving digital strategy and performance. However, business digitalisation does not really affect digital organisational values.
Strategic Attributes and Organizational Performance: Toward an Understanding of the Mechanism Applied to the Banking Sector
Authors: Tang Honglei , Rasool Zeeshan , Sarmad Muhammad , Ahmed Ammar , Ahmed Umair
Published: May 2022

The study examines and theorizes the importance of strategic attribute constructs (strategic orientation, organizational culture, and organizational internal market orientation) as applied to Pakistan’s banking sector by identifying their roles in enhancing organizational performance and the mediating effect of organizational commitment. The current study adopted quantitative research designs and methods to determine structural relationships between the proposed constructs. A total of 10 hypotheses were tested underpinned by the Resource-Based View of the Firm and Social Exchange theories. The strategic attributes studied were significantly and positively related to, and enhance, organizational performance if the banks: (1) focus on strategic positioning, (2) fostering a strong organizational culture, (3) strategize internal marketing practices, and (4) boost organizational commitment. The findings supported the mediating role of organizational commitment between strategic attributes and organizational performance. This study contributes to existing literature and supports prior research while filling in gaps in the literature concerning developing countries.
Adaptation of Work Values Instrument in Indonesian Final Year University Students
Authors: Sulistiobudi Rezki Ashriyana , Hutabarat Harlin Nikodemus
Published: May 2022

Background

One of the preferences working in the Generation Z is based on their motivational work values. The relevance of job choices with the work values will contribute to student career planning. The work value instrument among generations is one of the popular instruments used to measure final year students' work value, yet few studies of the psychometric properties of non-English language versions of this instrument. This study's objectives were to adapt a questionnaire of work value in Indonesian final year university students.

Methods

The number of participants in this study was 316 students in Indonesia, comprised of final year students from various majors who were selected by quota sampling. The instrument consisted of 5 dimensions of value, including leisure, extrinsic rewards, intrinsic rewards, altruistic rewards, and social rewards. The reliability analysis was performed using McDonald's Omega, the evidence of validity was obtained from test content, internal structure through confirmatory factor analysis (CFA), and evidence-based in relation to other variable has conducted the correlation between work value and career development learning using the Pearson's correlation coefficient.

Results

The results showed that the work values instrument had good psychometric properties, including good reliability, good content validity, and internal structure. In CFA, the two-factor structure showed satisfactory model fit. Moreover, the correlation of work value with career development learning builds stronger validity evidence on this instrument.

Conclusion

The adapted instrument can be used practically to identify work value preferences of final year students to help them choose a work preference and setup the career planning before graduating. The result could be of interest for the researcher in work value, motivational work, and career areas in higher education. To the best of our knowledge, there have been no reports about the adaptation of work value instruments in Indonesian final year university students.
Family Thriving During COVID-19 and the Benefits for Children’s Well-Being
Authors: Partington Lindsey C. , Mashash Meital , Hastings Paul D.
Published: May 2022

Although the COVID-19 pandemic has raised deserved concern regarding adverse impacts on parents’ and children’s mental health, regulations like “sheltering-in-place” may have afforded parents novel opportunities to foster positive family connections, thereby bolstering well-being. Using latent profile analysis (LPA), we (a) distinguished family thriving during shelter-in-place (May-June 2020) from other patterns of family functioning, (b) tested potential predictors of family functioning profiles, and (c) examined if family thriving predicted subsequent child adjustment (September–October 2020). 449 parents in two-parent U.S. families with children aged 2–18 years completed online surveys assessing (a) parent–child relationship quality, parents’ positive psychological adjustment, children’s emotional well-being, and parenting efficacy and satisfaction as family functioning indicators, (b) financial, marital, parental psychosocial assets, and child (age, gender, and temperament) predictors of family functioning, and (c) child adjustment. LPA identified four family functioning profiles: Thriving, Managing, Struggling, and Distressed. Thriving families evinced higher scores on all functioning indicators. Logistic regressions revealed that parents in Thriving families reported significantly lower financial anxiety, less dissatisfaction with partner’s help, less child emotionality, and greater use of cognitive reappraisal, as well as more positive child adjustment in Fall 2020. These findings underscore the multidimensional nature of coping and well-being during COVID-19. Utilizing these levers to promote mental health in families languishing during comparable future crises could promote resilience, thereby protecting children’s well-being.
Short and Long-Term Effects on Academic Performance of a School-Based Training in Self-Regulation Learning: A Three-Level Experimental Study
Authors: Tuero Ellián , Núñez José Carlos , Vallejo Guillermo , Fernández María Paula , Añón Francisco Javier , Moreira Tânia , Martins Joana , Rosário Pedro
Published: May 2022

An experimental study was designed to analyze the effect of school-based training in self-regulation learning strategies on academic performance (Mathematics, Sciences, Language, and English). Class-level variables (i.e., gender, the teacher’s teaching experience, class size) were considered and the effects of the intervention were measured at the end of the intervention and 3 months later. A sample of 761 students from 3rd and 4th grades (356 in the control condition and 405 in the experimental condition), from 14 schools, participated in the study. Data were analyzed using three-level analysis with within-student measurements at level 1, between-students within-classes at level 2, and between-classes at level 3. Data showed a positive effect of the intervention on student performance, both at post-test (d = 0.25) and at follow-up (d = 0.33) considering the four school subjects together. However, the effect was significant just at follow-up when subjects were considered separately. Student performance was significantly related to the students’ variables (i.e., gender, level of reading comprehension) and the context (teacher gender and class size). Finally, students’ gender and level of reading comprehension, as well as the teacher’s gender, were found to moderate the effect of the intervention on students’ academic performance. Two conclusions were highlighted: first, data emphasize the importance of considering time while conducting intervention studies. Second, more teaching experience does not necessarily translate into improvements in the quality of students’ instruction.
Environment, Social, and Governance Performance and Financial Performance With National Pension Fund Investment: Evidence From Korea
Authors: Son Sungjin , Kim Jootae
Published: May 2022

This study attempts to examine the relationship between environment, social, and governance (ESG) management and financial performance and the role of socially responsible investment in the National Pension Fund (NPF), Korea’s largest institutional investor. This study tries to provide evidence for the slack resource hypothesis by verifying whether companies with higher financial performance make more efforts to improve ESG performance. In addition, we tried to validate whether NPF is expanding its investments in corporations with high economic performance and high ESG performance. Based on our analysis, Korean companies with good financial performance actively participate in ESG. When we compared the performance between 2019 and 2020, companies with high ESG performance increased regardless of financial performance level, whereas companies with high financial performance and low ESG performance decreased. This represents that the perception and attitude of Korean companies toward ESG management are evolving. NPF has a high investment ratio for firms having a high ratio in both financial and ESG performance. NPF further invested in companies with high ESG performance, even if the financial performance is not decent. This study provides evidence that Korean companies’ interest in ESG management as well as the behavior of socially responsible investment of NPF are rising.
The Construction of Intelligent Emotional Analysis and Marketing Model of B&B Tourism Consumption Under the Perspective of Behavioral Psychology
Authors: Guo Wenru , Tang Daijian
Published: May 2022

This manuscript constructs an intelligent sentiment analysis and marketing model for bed and breakfast (B&B) consumption based on a behavioral psychology perspective. Based on the LDA theme model, the theme features and keywords of the reviews covering user feedback are explored from the text data, and the theme framework of user sentiment perception is constructed by combining previous literature on user perception in the B&B market, and the themes of user online reviews are summarized in four dimensions: practical, sensory, cognitive, and emotional components of user experience. In this manuscript, GooSeeker software was selected for data crawling and ROST CM (ROST content mining) developed by Wuhan University was used for text processing. To improve the accuracy of text classification and improve the missing data, the online comment text is divided into sentences by symbols, and the text is divided into words based on sentences, and the spatial vector model and the text feature word weighting method of TF-IDF are used for vector representation, and the polynomial Bayesian classifier is called to identify the topics of sentences. The classical Theory of Planned Behavior (TPB) was used to analyze the influencing factors of the willingness to consume experiential B&B tourism, and countermeasure suggestions for the development of B&B tourism were proposed based on the research findings In the empirical testing stage, a questionnaire on the willingness to consume experiential B&B tourism was designed, and web research was chosen to collect the data. SPSS20.0 was used to conduct reliability analysis, factor analysis, correlation analysis, and regression analysis on the data, and AMOS statistics were used to establish a structural equation model to verify the influence path of willingness to consume experiential B&B tourism. Finally, the moderating path of willingness to consume experiential B&B tourism was verified by using multi-group analysis.
Transformational and Transactional Leadership in the Polish Organizational Context: Validation of the Full and Short Forms of the Multifactor Leadership Questionnaire
Authors: Bajcar Beata , Babiak Jolanta
Published: May 2022

The Multifactor Leadership Questionnaire (MLQ 5X Short) is the most frequently used leadership measure in scholarship and organizational practice. However, so far it has not been validated in the Polish context. Therefore, the present study aimed to validate and shorten the MLQ (5X Short) in the Polish organizational setting. A total sample of 1,065 employees (572 women and 493 men) from different organizations took part in two sessions of an online study. Respondents were between 18 and 70 years old (M = 40.1; SD = 12.9) with an average job tenure of 17.00 years (SD = 12.1). In subsample 1 (n = 539), using exploratory factor analysis, a three-factor structure of the MLQ full form (MLQ-FF) was established, comprising transformational-supportive, inspirational goal-oriented, and passive-avoidant leadership. Based on qualitative (i.e., content analysis) and quantitative criteria (psychometric parameters), we constructed an 18-item MLQ short form (MLQ-SF). Both forms were supported by the confirmatory factor analysis in subsample 2 (n = 526). The MLQ-FF and MLQ-SF factors displayed acceptable to high levels of item-related parameters (e.g., intra-class, inter-item, and item-total correlations), as well as scale-related reliability (e.g., internal consistency, temporal stability). Both forms indicated high convergent and predictive validity examined by correlations with authentic leadership and employee's work outcomes (i.e., work satisfaction, work effectiveness, work engagement, and organizational commitment) (subsample 3; n = 691). Our study provided the full and the short form of the MLQ as reliable and valid instruments, potentially suitable to measure leadership styles in academic research and organizational practice.
Polypharmacy and Mental Health Issues in the Senior Hemodialysis Patient
Authors: Knehtl Maša , Petreski Tadej , Piko Nejc , Ekart Robert , Bevc Sebastjan
Published: May 2022

Hemodialysis (HD) is the most common method of chronic kidney failure (CKF) treatment, with 65% of European patients with CKF receiving HD in 2018. Regular two to three HD sessions weekly severely lower their quality of life, resulting in a higher incidence of depression and anxiety, which is present in one third to one half of these patients. Additionally, the age of patients receiving HD is increasing with better treatment and care, resulting in more cognitive impairment being uncovered. Lastly, patients with other mental health issues can also develop CKF during their life with need for kidney replacement therapy (KRT). All these conditions need to receive adequate care, which often means prescribing psychotropic medications. Importantly, many of these drugs are eliminated through the kidneys, which results in altered pharmacokinetics when patients receive KRT. This narrative review will focus on common issues and medications of CKF patients, their comorbidities, mental health issues, use of psychotropic medications and their altered pharmacokinetics when used in HD, polypharmacy, and drug interactions, as well as deprescribing algorithms developed for these patients.