bluuebunny/crossref_metadata_2025 huggingface dataset:
Association of Hsp70 locus polymorphism with thermotolerance and ailment occurrence in Gulf Creole cattle within intensive systems
Authors: Romero-Ramírez Laura A. , Cervantes Acosta Patricia , Domínguez-Mancera Belisario , Hernández-Beltrán Antonio
Published: September 2024

Objective: To estimate thermotolerance by analyzing physiological constants and ailment occurrence in Gulf Creole bovine cattle (GCB) and to relate them to Hsp70 locus polymorphism under an intensive production system.
Design/Methodology/Approach: Using a 440 bp fragment, we genotyped leukocyte DNA from 60 BCG through PCR-RFLP (Fok I). Physiological variables were estimated at 7-day intervals for four months during the hottest season. The variables considered were respiratory rate (RR) and layer temperature (LT). Environmental variables—temperature and humidity— were also recorded to determine thermal comfort. Using the production system database, we categorized the animals’ ailments during the studied period.
Results: The Hsp70 gene in GCB is polymorphic. The frequency of the AB heterozygous genotype was 0.77; for the AA homozygous genotype, it was 0.23. We observed a predominance of the A allele (0.61). Data analysis allowed us to find differences in RR in GCB with AA and AB genotypes (p<0.05). LT showed no differences (p>0.05). The genotype did not affect ailment occurrence in GCB (p>0.05).
Study limitations/implications: Since the intensive system is dynamic, and the GCB stay period is short, few animals were available for the study.
Findings/Conclusions: The Hsp70 gene present in GCB is polymorphic, and the animals are thermotolerant. Their performance regarding the occurrence of clinical conditions is favorable.
Moth trapping of males using Diatraea spp. (Lepidoptera: Crambidae) pupae in sugarcane plantations
Authors: Durán-Martínez Diana , Hernández-Rosas Francisco , Hidalgo-Contreras Juan Valente , Grifaldo-Alcántara Fabian
Published: September 2024

Objective: To standardize the moth trapping method through the use of Delta traps with Diatraea pupae to lure males.
Design/Methodology/Approach: The following lure types were placed inside Delta traps: two female pupae (T1), three female pupae (T2), and two female pupae with one adult female (T3). The response variable was the number of male moths captured per trap. An analysis of variance and Tukey’s test (p≤0.05) were performed.
Results: Statistical differences (p≤0.05) were observed between T3 and T1/T2: T3 trapped the lowest number of specimens (0.94 adults/trap) from May to July 2022. Likewise, June recorded the highest abundance of Diatraea moths (3.05 adults/trap). Nevertheless, T1 captured the highest number of specimens (4.16).
Study Limitations/Implications: The use of commercial pheromones has been established as a useful moth trapping method in the case of stem borers. In recent years, no favorable results have been observed with the use of pheromones of the D. saccharalis, D. grandiosella, and D. considerata species in Delta traps. These findings could be indicative of the presence of another Diatraea species.
Findings/Conclusions: The use of two Diatraea pupae per trap attracts male moths. This method would help to detect and regulate moths, with the aim of interrupting their life cycle
“They are here. They are everywhere. They are us.” – Posthuman Encounters in Samanta Schweblin’s Little Eyes (2018)
Authors: Missler Heike
Published: September 2024

In Little Eyes (2018), the latest technological hype comes in the shape of cute, pet-like robots with cameras for eyes. These so-called kentukis are remotely inhabited and controlled by their human users via an online connection which is established at random. As the novel’s blurb - “They are here. They are everywhere. They are us.” - suggests, a kentuki is at once a familiar and unfamiliar creature and users’ experiences range from comforting to unsettling. The novel revolves around the theme of stranger danger and reports several uncanny encounters between humans and not-quite-humans in places around the world. The representation of these posthuman interactions in the novel remains ambiguous: Even though the potential to challenge or even transgress the human/non-human binary is addressed, the novel follows a classic dystopian narrative, which posits that it is not the technology itself which is inherently good or bad, it is us humans.
Phân tích trắc lượng thư mục các xu hướng nghiên cứu trong lĩnh vực nghiên cứu về trung hòa các-bon
Authors: Nguyễn Thùy Linh
Published: September 2024

Trong bối cảnh biến đổi khí hậu và nóng lên toàn cầu, trung hòa các-bon đã trở thành mục tiêu quan trọng của cộng đồng quốc tế. Nghiên cứu này sử dụng phương pháp phân tích trắc lượng thư mục để đánh giá sự phát triển và xu hướng nghiên cứu về trung hòa các-bon từ năm 2000 đến nay. Bằng cách phân tích 2827 ấn phẩm liên quan từ cơ sở dữ liệu Scopus qua công cụ Biblioshiny trên Rstudio, nghiên cứu này cung cấp bức tranh toàn cảnh về các xu hướng nghiên cứu trong lĩnh vực trung hòa các-bon. Kết quả cho thấy sự gia tăng đáng kể về số lượng ấn phẩm trong những năm gần đây, các nghiên cứu trong lĩnh vực này chủ yếu tập trung vào các khía cạnh ứng dụng thực tiễn, kỹ thuật, chính sách, và kinh tế của trung hòa các-bon. Năng lượng tái tạo, công nghệ chuyển đổi các-bon, và công nghệ thu giữ và lưu trữ các-bon đang là những điểm nóng nghiên cứu trên thế giới. Nghiên cứu này phân tích toàn diện về các xu hướng nghiên cứu hiện tại và đề xuất các định hướng cho các nghiên cứu trong tương lai.
PENINGKATAN PENGETAHUAN MASYARAKAT DALAM PEMANFAATAN INTERNET MELALUI PROGRAM LITERASI DIGITAL
Authors: Pariyatin Yeni , Hendryawan Paschal , Nursyahidah Adhya , Kurnia Ade , Fitriani Nadia , Nurhakim Irfan , Darmawan Mochamad Ab Rizky , Hidayat Muhamad Saepul , Solihah Annisa Siti , Hesti Hesti , Falah Romy Rohmatul , Wildan Muhammad , Fadlurrohman Muhamad Daffa , Rizki Angga M , Rachman Bella Putriyani , Haerani Wilda , Praditya Salman , Aziz Fajar Abdul , Nurhakim Rizal , Athfaal Khoirul
Published: September 2024

Di era digital saat ini, akses dan pemahaman tentang literasi digital menjadi kunci untuk mengatasi ketidaksetaraan dalam akses pendidikan, pekerjaan, dan ekonomi. Desa Sirnagalih, sebuah komunitas pedesaan di Kecamatan Bayongbong Kabupaten Garut, Jawa Barat, menghadapi tantangan dalam mengadopsi teknologi digital. Program literasi digital melalui seminar menjadi solusi yang efektif untuk meningkatkan pemahaman dan keterampilan masyarakat dalam menggunakan internet secara sehat dan produktif. Kuliah Kerja Nyata Tematik 2023 Sekolah Tinggi Teknologi Garut, bertujuan memberikan kontribusi kepada masyarakat Desa Sirnagalih khususnya Kampung Babakan dan Depok dalam bentuk pengetahuan atau edukasi dan kegiatan seminar yang bertema tentang Berkembang Cerdas, Aman dan Membangun Kemampuan Literasi Digital. Hasil pembahasan menunjukkan program literasi digital melalui edukasi ke sekolah dan seminar dalam upaya meningkatkan pengetahuan masyarakat Kampung Babakan Depok Desa Sirnagalih dalam memanfaatkan internet yang cerdas aman secara umum mendapat tanggapan positif.
Vulnerabilidad y Desarrollo en Ecuador
Authors: Chiriboga-Pinos Juan , Gaibor-Velasco Numa , Monteros-Pazmiño David
Published: September 2024

Ecuador enfrenta múltiples desafíos en su camino hacia el desarrollo sostenible, incluyendo pobreza, desigualdad, desastres naturales y la eficacia de sus políticas gubernamentales. Aproximadamente el 25% de la población vive en pobreza, situación exacerbada en las zonas rurales donde el acceso a servicios básicos es limitado. La informalidad laboral y la falta de oportunidades económicas son factores clave en la persistencia de la pobreza. La desigualdad en Ecuador se manifiesta en ingresos, educación y acceso a servicios, con una marcada brecha entre sectores ricos y pobres. La calidad educativa es desigual entre áreas urbanas y rurales, perpetuando el ciclo de pobreza y limitando el desarrollo inclusivo. El país es vulnerable a desastres naturales como terremotos, erupciones volcánicas, deslizamientos e inundaciones, que tienen efectos devastadores en las comunidades afectadas. La gestión de estos desastres requiere un enfoque integral que incluya prevención, preparación, respuesta y recuperación. Las políticas gubernamentales son cruciales para reducir la vulnerabilidad y promover el desarrollo. Programas como el Bono de Desarrollo Humano buscan apoyar a las familias en pobreza extrema, pero es necesario evaluarlos y ajustarlos continuamente. Además, es fundamental fomentar políticas que promuevan el crecimiento económico inclusivo, la diversificación productiva y la sostenibilidad ambiental. La inversión en infraestructura, educación y salud es esencial para crear un entorno propicio para el desarrollo sostenible. Solo a través de un compromiso conjunto entre el gobierno, la sociedad civil y el sector privado, Ecuador podrá superar sus vulnerabilidades y avanzar hacia un futuro más justo y resiliente.
Can primary hyperaldosteronism be considered as a specific form of diabetes mellitus?
Authors: Widimský J , Strauch B , Šindelka G , Škrha J
Published: September 2024

Aldosterone-producing adenoma (aldosteronoma) - the most frequent form of primary hyperaldosteronism (PH) - is considered a specific form of diabetes mellitus (DM). In a previous study we demonstrated insulin resistance in patients with PH. We have therefore undertaken a study to evaluate the incidence of abnormalities of glucose metabolism in patients with PH (36 subjects) compared to control subjects with essential hypertension (EH) (21 patients). The following parameters were measured in all studied subjects: office blood pressure (by mercury sphygmomanometer in the sitting position), body mass index (BMI), plasma potassium, plasma glucose and insulin levels during oral glucose tolerance test (OGTT) (0, 60, 120 min), plasma renin activity and plasma aldosterone. Although patients with PH tended to have higher stimulated plasma glucose levels after 60 and 120 min compared to EH, these differences did not attain statistical significance. Patients with EH tended to have higher insulin levels at each measured interval, but due to a high variability these differences were again not significant. There were no significant differences between PH and EH in the proportion of diabetics (20 % vs. 14 %) or patients with impaired glucose tolerance (18 % vs. 10 %). In conclusion, we have found the absence of significant differences in the frequency of diabetes mellitus, impaired glucose tolerance and insulin resistance in patients with EH and PH. Our data thus do not support the idea of primary hyperaldosteronism as a specific type of diabetes mellitus. Furthermore, our results indicate that glucose metabolic characteristics in essential hypertension and primary hyperaldosteronism tend to be similar. The definitive conclusion with respect to the possible causal relationship between DM and PH, however, can be obtained only on larger groups of subjects, in particular after the evaluation of the effect of surgical/pharmacological treatment of primary hyperaldosteronism.
The biological carbon pump and seaweeds
Authors: Silkin Vladimir A. , Kamnev Alexander N. , Lifanchuk Anna V. , Stukolova Irina V.
Published: September 2024

The interest of researchers in macrophytes in the seventies and eighties of the last century was associated with the need to obtain technologically important products, and by the end of the last century, technologies for cultivating several important species of algae were created and put into practice. Currently, the problem of climate change requires new approaches to find ways to transfer inorganic carbon from the atmosphere to the ocean floor. One of the ways to sequester inorganic carbon seems to be the creation of systems based on marine macrophytes. This should stimulate research into natural populations of macrophytes and the organization of cultivation methods according to a new optimization criterion, namely the optimal transfer of atmospheric carbon to the ocean floor.
Studi Literatur Mengenai Klasifikasi Citra Kucing Dengan Menggunakan Deep Learning: Convolutional Neural Network (CNN)
Authors: Linda Kumara Dewi , Kusrini Kusrini , Hartanto Anggit Dwi
Published: September 2024

Deep learning merupakan bagian dari machine learning yang memiliki kemampuan untuk mengenali pola gambar, suara, teks dan data lainnya yang kompleks sehingga dapat menghasilkan prediksi yang akurat. Salah satu kemampuan deep learning adalah klasifikasi citra pada objek. CNN adalah salah satu metode dalam machine learning yang digunakan untuk mengklasifikasikan citra objek. Algoritma Convolutional Neural Network (CNN) adalah bagian dari deep learning network yaitu jenis jaringan saraf tiruan yang saat ini banyak digunakan untuk pengenalan suatu citra. Dalam penelitian ini, algoritma yang digunakan adalah CNN karena akurasinya yang cukup baik. Deep learning dengan convolutional neural network (CNN) yang banyak digunakan untuk melakukan deteksi, klasifikasi, dan prediksi pada gambar. Citra objek dalam penelitian ini adalah kucing yang terdiri dari berbagai macam jenis. Tujuan dari penelitian ini adalah untuk mengklasifikasikan citra kucing sesuai dengan jenisnya. Jurnal ini merupakan tinjauan literatur untuk menambah pengetahuan berharga mengenai penelitian terbaru tentang klasifikasi citra kucing menggunakan CNN. Jurnal ini membahas studi literatur tentang variabel input, metode yang digunakan dan hasil literatur dari penelitian sebelumnya. Metode yang paling banyak digunakan pada penelitian sebelumnya adalah CNN
Rancang Bangun Aplikasi Bank Sampah Universitas Syiah Kuala Berbasis Web
Authors: Deviani Rini , Aflah Tsani , Misbullah Alim
Published: September 2024

Bank Sampah Universitas Syiah Kuala merupakan solusi dari Universitas Syiah Kuala untuk mengatasi dampak negatif dari peningkatan produksi sampah. Kesadaran masyarakat terhadap pengelolaan sampah yang terus berkembang telah mendorong peningkatan jumlah nasabah Bank Sampah USK. Pertumbuhan nasabah ini memunculkan masalah diantaranya sistem administrasi dan transaksi yang belum terstruktur, serta tidak adanya platform untuk menyebarluaskan informasi dan berita mengenai Bank Sampah USK kepada masyarakat. Adapun cara untuk mengatasi tantangan ini adalah dengan membangun aplikasi Bank Sampah USK berbasis web. Aplikasi ini dikembangkan menggunakan model waterfall sehingga tahapannya dikerjakan secara berurutan,mulai dari tahap identifikasi masalah yang dialami pengguna, tahap pengerjaan kode dengan bahasa pemrograman PHP hingga tahap dilakukannya pengujian untuk memastikan sistem berjalan dengan baik serta memberikan pengalaman pengguna yang optimal. Fitur-fitur aplikasi yang dihasilkan mencakup kemampuan pengunjung web untuk melihat informasi/berita oleh Bank Sampah USK. Administrator dapat mengelola informasi/berita, nasabah, setoran, jenis sampah, dan konfirmasi penarikan dana. Nasabah dapat mengelola profil, melakukan penarikan saldo, serta melihat riwayat setoran dan penarikan. Hasil analisis pengujian fungsionalitas menunjukkan bahwa aplikasi ini berhasil menjalankan semua skenario black box testing dan mendapatkan penilaian usability "Good" oleh 30 responden, dengan grade scale ‘B’ dan acceptability range berada pada kategori ‘Acceptable’.
Analisis Teknis Dan Ekonomi Pembangkit Listrik Tenaga Surya Atap Berbasis PVsyst
Authors: Juli Sutiawan Dimas Eka , Notosudjono Didik , Rijadi Bloko Budi , Yamato Yamato
Published: September 2024

Penggunaan Pembangkit Listrik Tenaga Surya merupakan teknologi yang berkembang dibidang pembangkit listrik yang memanfaatkan sumber energi matahari dan diubah menjadi energi listrik dengan alat bantu modul surya. Hal tersebut sejalan dengan keputusan Rektor Universitas Pakuan No.204/7KEP/REK/X/2022 tentang “Penetapan Kebijakan Penghematan Energi Listrik di Lingkungan Kampus Universitas Pakuan”. Tujuan dari pemasangan PLTS yaitu pengurangan pemakaian listrik dari jaringan untuk mengurangi tagihan bulanan listrik. Peluang untuk penggunaan PLTS On-Grid pada Gedung Perkuliahan Fakultas Teknik Universitas cukup baik, dikarenakan potensi radiasi matahari rata-rata pada Kota Bogor yaitu 2,66 kWh/ m². Hal yang perlu diperhatikan dalam analisis teknis dan ekonomi PLTS On-Grid ini yaitu pemilihan komponen, lokasi pemasangan, luas atap gedung dan faktor ekonomi. Dalam penelitian ini menggunakan perhitungan perencanaan dan membandingkan dengan hasil dari simulasi PVsyst. Komponen yang digunakan yaitu modul surya jenis monocrystalline dengan kapasitas 550 Wp berjumlah 50 buah panel surya dipasang secara seri dalam 3 string, di setiap string terdapat 22 buah panel surya, dengan menggunakan 2 buah inverter dan 2 MPPT dengan kapasitas 22 kVA. Berdasarkan dari hasil perhitungan perencanaan, daya yang dihasilkan dari PLTS OnGrid untuk memenuhi kebutuhan listrik dalam satu tahun yaitu sebesar 22694,787 kWh/tahun dan Performance Ratio sebesar 85%. Untuk biaya investasi awal yang dibutuhkan sebesar Rp. 246.419.576 dan periode pengembalian investasi awal dalam 14 tahun, dengan pengoperasian PLTS berlangsung selama 20 tahun serta minimal biaya energi yang dihasilkan dari PLTS pertahun sebesar Rp. 20.425.308 dan total akumulasi saving jika PLTS terpasang sebesar Rp. 427.701.220.
Pengaruh Nilai Waktu Pada Biaya Operasional Kendaraan Dalam Pemilihan Rute Perjalanan Melalui Desa Meluhu dan Pohara Antar Kabupaten Konawe - Konawe Utara
Authors: K Erwin
Published: September 2024

Dewasa ini perkembangan mobilitas seseorang cenderung membutuhkan waktu yang lebih singkat, dimana waktu adalah komoditi yang tidak dapat dihemat ataupun disimpan sehingga bagi setiap orang waktu merupakan hal yang sangat penting. Dalam hal ini nilai waktu berubah sesuai dengan tingkat pendapatan, apabila dihadapkan dengan dua pilihan yaitu melalui Jalan Desa Meluhu dan melalui Jalan Desa Pohara menuju Kabupaten Konawe Utara seseorang dengan tingkat pendapatan tinggi cenderung menghargai nilai waktu dengan memilih rute yang mempunyai nilai waktu lebih efisien. Tujuan dari penelitian ini ialah menganalisa pengaruh nilai waktu perjalanan pengguna jalan dalam besarnya Biaya Operasional Kendaraan (BOK) terhadap pemilihan rute pada melalui Jalan Desa Meluhu dan melalui Jalan Desa Pohara dengan Model Logit Binomial. Metodologi dalam penelitian ini ialah untuk menganalisis nilai waktu perjalanan digunakan metode Income Approach, kemudian untuk menganalisis hasil perhitungan nilai BOK digunakan rumus PCI (Pacific Consultant International), kemudian untuk menganalisis pemilihan rute dengan Model Logit Binomial. Hasil analisis dapat disimpulkan bahwa semakin besar nilai waktu pengguna jalan maka probabilitas pemilihan rute-A juga semakin meningkat, dikarenakan nilai waktu pengguna jalan dengan pendapatan yang lebih besar, lebih penting dibandingkan dengan nilai waktu pengguna jalan dengan pendapatan yang lebih rendah.kata kunci : Nilai Waktu, Biaya Operasional Kendaraan, Pemilihan Rute
PEMERIKSAAN MATERIAL SUNGAI ASAL QUARY DESA BORO-BORO KECAMATAN RANOMEETO KABUPATEN KONAWE SELATAN SEBAGAI BAHAN LAPIS PERKERASAN KELAS S
Authors: Hardyanty Vivin
Published: September 2024

Salah satu sumber material di Sulawesi Tenggara yang cukup potensial untuk digunakan adalah material yang berasal dari quary Desa Boro-Boro Kecamatan Ranomeeto Kabupaten Konawe Selatan dengan suplay material yang cukup banyak dan dapat digunakan untuk beberapa tahun kedepan. Dimana material dilokasi tersebut sudah lama dimanfaatkan oleh masyarakat sekitarnya untuk keperluan bahan konstruksi jalan dan bangunan sipil, sedangkan pemeriksaan mutu material khususnya sebagai bahan perkerasan kelas S belum pernah dilakukan maka dilakukanlah pengujian terhadap material tersebut. Tujuan dari penelitian ini adalah untuk menganalisa hasil yang dicapai dari uji laboratorium terhadap material sungai asal quary Desa Boro-Boro Kecamatan Ranomeeto Kabupaten Konawe Selatan memenuhi atau tidak memenuhi spesifikasi yang akan digunakan sebagai bahan konstruksi pada lapis pondasi agregat kelas S.Lapis Perkerasan Kelas S merupakan lapis pondasi yang biasa digunakan pada perkerasan lentur. Spesifikasi jalan mengharuskan campuran bahan lapis pondasi kelas S harus memiliki nilai CBR min 50 %. Hal ini mengakibatkan seluruh material harus memenuhi syarat dan ketentuan yang ada didalam spesifikasi agar nilai nilai yang ada dalam spesifikasi terpenuhi. Pengujian dilakukan dengan dua tahap atau dua fraksi. Tahap pertama pengujian dilakukan hanya dengan menggunakan satu bahan saja yaitu menggunakan sirtu boro boro. Tahap kedua pengujian dilakukan dengan campuran dari tiga bahan yaitu sirtu boro boro, batu pecah moramo, dan tanah alolama. Dari hasil penggabungan agregat diperoleh komposisi material sirtu boro boro 55 %, batu pecah moramo 40 %, tanah alolama 5 % . Hasil pengujian diperoleh nilai CBR laboratorium untuk LPA (sirtu boro boro) diperoleh nilai CBR 27,25 %, LPA (sirtu boro boro + batu pecah moramo + tanah alolama) diperoleh nilai CBR 51,90%. berdasarkan nilai CBR , sirtu boro boro dapat digunakan pada lapis perkerasan kelas S dengan komposisi yang telah diperoleh pada penelitian dilaboratorium.Kata Kunci : Sirtu Boro-Boro, CBR, LPA
ANALISIS TINGKAT PELAYANAN PENUMPANG KAPAL FERRY DI PELABUHAN TOROBULU PADA SAAT PANDEMI COVID-19
Authors: Safrudin Safrudin , Kadir Abdul , Magribi La Ode Muhammad
Published: September 2024

Pelayanan sangat erat kaitannya dengan masyarakat, sehingga pelayanan kepada masyarakat lebih dikenal dengan istilah pelayanan publik. PT. ASDP (Persero) Cabang Torobulu sebagai sebuah perusahaan yang bergerak dalam memberikan pelayanan kepada publik tentu erat kaitannya dengan pelayanan yang sistematis dan komprehensif, sebagai barometer dalam mengukur keberhasilan dalam pelayanan kepada pengguna jasa layanan.Penelitian ini bertujuan untuk mengidentifikasi karakteristik penumpang kapal ferry terhadap isu pandemi COVID-19, dan mengukur kepuasan penumpang terhadap pelayanan, serta menganalisis atribut – atribut penting untuk perbaikan pelayanan pelabuhan Torobulu. Penelitian ini dilakukan dengan menggunakan metode Importance Performance Analysi (IPA) dan metode Customer Satisfaction Index (CSI), serta menganalisis habungan antara isu kontemporer tentang pandemi COVID-19 dengan jenis kelamin menggunakan analisis deskriptif Analisis Crosstab dengan Melihat Uji Chi-square.Dari hasil analisis diperoleh bahwa karakteristik penumpang mayoritas laki-laki berusia 21 – 30 tahun, SMA/Sederajad dan wiraswasta. Tingkat pelayanan penumpang kapal ferry adalah sebesar 75 % dengan kategori puas, serta pada diagram kartesius dari 28 atribut terdapat 4 atribut yang memerlukan prioritas perbaikan atau peningkatan yaitu atribut kebersihan dan kerapihan lingkungan pelabuhan, atribut menepati janji dalam memberi pelayanan, atribut pegawai memberikan informasi yang terbaru tentang jadwal keberangkatan kapal, dan atribut pegawai dapat memahami kebutuhan spesifik pengguna layanan.Kata Kunci : Tingkat pelayanan, Tingkat kepuasan, Importance Performance Analysi (IPA), Customer Satisfaction Index (CSI)
Implemetasi Sistem Keamanan pada Jaringan Server Pemilu Raya (PEMIRA) Universitas Halu Oleo (UHO) Menggunakan Metode Intrusion Prevention System (IPS) Suricata
Authors: Aksara L.M Bahtiar , Surimi La , Nuralam Wa Ode Siti
Published: September 2024

Keamanan pada sebuah jaringan server merupakan salah satu aspek yang penting selain keamanan dari sisi aplikasi. Seiring dengan berkembangnya teknologi yang semakin pesat, berdampak pula pada sistem keamanan jaringan khususnya jaringan pada server. Kebutuhan akan keamanan tentunya akan sangat dibutuhkan karena meningkatnya ilmu pengetahuan tentang hacking. Universitas halu oleo memanfaat server untuk berbagai jenis kegiatan, salah satunya ada Pemilu Raya (PEMIRA) BEM Universitas. Pemira merupakan agenda pemilihan Ketua BEM Universitas, BEM Fakultas, DPM dan MPM dan Kegiata pemira ini melibatkan seluruh elemen mahasiswa dalam jumlah yang banyak. Karena pentongnya kegiatan ini, maka server perlu dijaga keamanannya. Oleh karena itu dibutuhkan system yang dapat mencegah serangan terjadi terhadap server. Sistem tersebut adalah Instrusion Prevention System (IPS). Sistem keamanan menggunakan IPS dapat memblokir attacker dan memberikan alert kepada administrator saat melakukan monitoring data pada server pemira dan juga dapat mengatasi mobilitas administrator untuk memonitor serangan kapanpun dan dimanapun.Kata Kunci : Server, Pemira, IPS, Keamanan, e-voting
Evaluating Lung Changes in Long COVID: Ultra-Low‐Dose vs. Standard‐Dose CT Chest
Authors: Devkota Shritik , Garg Mandeep , Debi Uma , Dhooria Sahajal , Dua Ashish , Prabhakar Nidhi , Soni Saumya , Maralakunte Muniraju , Gulati Ajay , Singh Tarvinder , Sandhu Manavjit Singh
Published: September 2024

Background

Frequent chest CTs within a short period during follow-up of long COVID patients may increase the risk of radiation-related health effects in the exposed individuals. We aimed to assess the image quality and diagnostic accuracy of ultra-low-dose CT (ULDCT) chest compared to standard-dose CT (SDCT) in detecting lung abnormalities associated with long COVID.

Methods

In this prospective study, 100 long COVID patients with respiratory dysfunction underwent SDCT and ULDCT chest that were compared in terms of objective (signal-to-noise ratio, SNR) and subjective image quality (image graininess, sharpness, artifacts, and diagnostic accuracy along with the European guidelines on image quality criteria for CT chest), detection of imaging patterns of long COVID, CT severity score, and effective radiation dose. Additionally, the diagnostic performance of ULDCT was compared among obese (BMI≥30 kg/m2) and non-obese (BMI<30 kg/m2) subjects.

Results

The mean age of study participants was 53 ± 12.9 years, and 68% were male. The mean SNR was 31.4 ± 5.5 and 11.3 ± 4.6 for SDCT and ULDCT respectively (p< 0.0001). Common findings seen on SDCT included ground-glass opacities (GGOs, 77%), septal thickening/reticulations (67%), atelectatic/parenchymal bands (63%) and nodules (26%). ULDCT provided sharp images, with no/minimal graininess, and high diagnostic confidence in 81%, 82% and 80% of the cases respectively. The sensitivity of ULDCT for various patterns of long COVID was 72.7% (GGOs), 71.6% (interlobular septal thickening/reticulations), 100% (consolidation), 81% (atelectatic/parenchymal bands) and 76.9% (nodules). ULDCT scans in non-obese subjects exhibited a significantly higher sensitivity (88% vs. 60.3%, p < 0.0001) and diagnostic accuracy (97.7% vs. 84.9%, p < 0.0001) compared to obese subjects. ULDCT showed very strong correlation with SDCT in terms of CT severity score (r = 0.996, p < 0.0001). The mean effective radiation dose with ULDCT was 0.25 ± 0.02 mSv with net radiation dose reduction of 94.8% ± 1.7% (p < 0.0001) when compared to SDCT (5.5 ± 1.96 mSv).

Conclusion

ULDCT scans achieved comparable diagnostic accuracy to SDCT for detecting long COVID lung abnormalities in non-obese patients, while significantly reducing radiation exposure.
A new strategy in bioreactor scale-up and process transfer using a dynamic initial vvm according to different aeration pore size
Authors: Ding Huaping , Cheng Huanghe , Wu Jiaxian , Zhang Fan , Cao Can , Mualif Siti Aisyah , Xie Zhenggang
Published: September 2024

Monoclonal antibody drugs have grown into a drug category with a market size of over $100 billion since the first product was launched on the market, which naturally creates a large demand for production. At the same time, the $100 billion market is distributed among more than 200 listed drugs, which indicates that the production demand for monoclonal antibody drugs is diverse. To meet this demand, major suppliers offer single-use bioreactors of all sizes. These single-use bioreactors with different specifications, especially the inconsistency of aeration pore sizes, pose great challenges for technology transfer and scale-up production, and the conventional scale-up strategies of constant Power input/volume ratio (P/V) and constant vessel volume per minute (vvm) can no longer meet the needs. This study simplified the selection of technical parameters in bioreactors based on the differences in aeration pore size. Innovatively combined the aeration pore sizes with initial aeration vvm, and comprehensively investigated the relationship between P/V, vvm and aeration pore size by designing experiments (DoE) using the orthogonal test method. The results showed a quantitative relationship between the aeration pore size and the initial aeration vvm in the P/V range of 20 ± 5 W/m3. The appropriate initial aeration was between 0.01 and 0.005 m3/min for aeration pore size ranging from 1 to 0.3 mm, which was the optimal incubation condition in the bioreactors. The choice of initial ventilation was most related to the final expression. Follow-up studies validated these findings in a 15 L glass bioreactor and a 500 L single-use bioreactor, and the results were consistent with expectations.
Cardiovascular disease in thymic cancer patients
Authors: Khemka Abhishek , Clasen Suparna C. , Loehrer Patrick J. , Roberts Anna R. , Golzarri-Arroyo Lilian , Badve Sunil S. , Raman Subha V. , Hui Siu L. , Schleyer Titus K. L.
Published: September 2024

Introduction

Cancer patients may have increased risk for adverse cardiac events, but our understanding of cardiovascular risk in thymic cancer patients is not clear. We sought to characterize baseline cardiometabolic risk factors before thymic cancer diagnosis and the potential association between cancer treatment and subsequent cardiac events.

Methods

This was a retrospective cohort study evaluating patients with thymic cancer from 2003 to 2020 compared to age- and sex-matched controls without cancer. Baseline cardiovascular risk factors, cancer characteristics, and incidence of cardiac events were collected from the health information exchange. Multivariable regression was used to examine the impact of cardiovascular risk factors and cancer therapies.

Results

We compared 296 patients with pathology-confirmed thymic cancer to 2,960 noncancer controls. Prior to cancer diagnosis, thymic cancer patients (TCPs) had lower prevalence of hypertension, dyslipidemia, and diabetes mellitus and similar rates of obesity, tobacco use, and pre-existing cardiovascular disease (CVD) compared to controls. After diagnosis, high-risk TCPs (>2 cardiovascular risk factors or pre-existing CVD) had higher risk for cardiac events (HR 3.73, 95% CI 2.88–4.83, p < 0.001). In the first 3 years after diagnosis, TCPs had higher incidence of cardiac events (HR 1.38, 95% CI 1.01–1.87, p = 0.042). High-risk TCPs who received radiotherapy or chemotherapy had higher risk of cardiac events (HR 4.99, 95% CI 2.30–10.81, p < 0.001; HR 6.24, 95% CI 2.84–13.72, p < 0.001).

Discussion/conclusion

Compared to noncancer controls, TCPs experienced more cardiac events when adjusted for risk factors. Patients with multiple cardiovascular risk factors receiving radiotherapy or chemotherapy had higher incidence of cardiac events.
Ten-year clinical outcomes of everolimus- and biolimus-eluting coronary stents vs. everolimus-eluting bioresorbable vascular scaffolds—insights from the EVERBIO-2 trial
Authors: Bengueddache Samir , Cook Malica , Lehmann Sonja , Arroyo Diego , Togni Mario , Puricel Serban , Cook Stephane
Published: September 2024

Background

Bioresorbable vascular scaffolds (BVSs) have been developed as a potential solution to mitigate late complications associated with drug-eluting metallic stents (DESs) in percutaneous coronary intervention for coronary artery disease. While numerous studies have compared BVSs to DESs, none have assessed clinical outcomes beyond 5 years.

Objectives

This study aimed to compare the 10-year clinical outcomes of patients treated with BVSs vs. DESs.

Methods

The EverBio-2 trial (Comparison of Everolimus- and Biolimus-Eluting Coronary Stents with Everolimus-Eluting Bioresorbable Vascular Scaffold) is a single-center, assessor-blinded, randomized controlled trial that enrolled 240 patients allocated in a 1:1:1 ratio to receive BVSs, everolimus-eluting stents, or biolimus-eluting stents (BESs). Clinical follow-up was scheduled for 10 years.

Results

Clinical follow-up was completed in 222 patients (93%) at the 10-year mark. The rate of device-oriented composite events (DOCE) was 28% in the DES group and 29% in the BVS group (p = 0.72) at 10 years. Similarly, the rate of patient-oriented composite events (POCE) was 55% in the DES group and 49% in the BVS group (p = 0.43) at 10 years. Notably, the rate of myocardial infarction (MI) within the target vessel was 5% in the BVS group and 0% in the BES group (p = 0.04), while the rate of any MI was 10% in the BVS group and 2% in the BES group (p = 0.04). In addition, the rate of Academic Research Consortium (ARC) possible stent thrombosis was 3% in the BVS group and 0% in the DES group (p = 0.04).

Conclusions

Over 10 years, the rates of clinical DOCE and POCE were similar between the BVS and DES groups but individual outcomes of stent thrombosis were higher (3%) in the BVS group compared to the DES group.

Clinical Trial Registration

ClinicalTrials.gov, identifier (NCT01711931).
A stacked machine learning-based classification model for endometriosis and adenomyosis: a retrospective cohort study utilizing peripheral blood and coagulation markers
Authors: Wang Weiying , Zeng Weiwei , Yang Sen
Published: September 2024

Introduction

Endometriosis (EMs) and adenomyosis (AD) are common gynecological diseases that impact women's health, and they share symptoms such as dysmenorrhea, chronic pain, and infertility, which adversely affect women's quality of life. Current diagnostic approaches for EMs and AD involve invasive surgical procedures, and thus, methods of noninvasive differentiation between EMs and AD are needed. This retrospective cohort study introduces a novel, noninvasive classification methodology employing a stacked ensemble machine learning (ML) model that utilizes peripheral blood and coagulation markers to distinguish between EMs and AD.

Methods

The study included a total of 558 patients (329 with EMs and 229 with AD), in whom key hematological and coagulation markers were analyzed to identify distinctive profiles. Feature selection was conducted through ML (logistic regression, support vector machine, and K-nearest neighbors) to determine significant hematological markers.

Results

Red cell distribution width, mean corpuscular hemoglobin concentration, activated partial thromboplastin time, international normalized ratio, and antithrombin III were proved to be the key distinguishing indexes for disease differentiation. Among all the ML classification models developed, the stacked ensemble model demonstrated superior performance (area under the curve = 0.803, 95% credibility interval = 0.701–0.904). Our findings demonstrate the effectiveness of the stacked ensemble ML model for classifying EMs and AD.

Discussion

Integrating biomarkers into this multi-algorithm framework offers a novel approach to noninvasive diagnosis. These results advocate for the application of stacked ensemble ML utilizing cost-effective and readily available peripheral blood and coagulation indicators for the early, rapid, and noninvasive differential diagnosis of EMs and AD, offering a potentially transformative approach for clinical decision-making and personalized treatment strategies.
Case report: Breaking CNS immuno-privilege: TNFα-inhibitor triggers aseptic meningitis in a patient with rheumatoid arthritis
Authors: Kassabian Benedetta , Facco Monica , Miscioscia Alessandro , Carraro Samuela , Rinaldi Francesca , Gallo Paolo , Puthenparampil Marco
Published: September 2024

Blood-brain barrier dysfunction might be driven by peripheral inflammation. TNFα inhibitors (TNF-αi) are occasionally associated with a wide spectrum of neurological immuno-mediated disorders. However, patients with systemic autoimmune disorders, including rheumatoid arthritis (RA), might be prone to develop further organ-specific, including central nervous system (CNS), autoimmunity. Here we report the case of a patient, affected by RA and treated with etanercept, who suddenly developed focal neurological symptoms. Cerebrospinal fluid, magnetic resonance imaging (MRI), and positron emission tomography (PET)/MRI findings are reported and support the diagnosis of TNF-αi -associated aseptic meningitis.
Prevalence and species identification of trematode metacercariae in Qiqihar, Northeast China
Authors: Zhang Fengyu , Li Jianke , Zhang Shaocheng , Chen Ting , Zhang Hao
Published: September 2024

Fishborne trematode (FBT) is an important group of parasites that are endemic worldwide to a certain extent. However, despite the epidemiological significance, the species and phylogenetic evolution characteristics of FBT metacercariae have not been well studied. In this study, a total of 600 Pseudorasbora parva (P. parva) specimens were collected from Qiqihar, 61.8% (371/600) were found to be infected with trematode metacercariae. A total of three kinds of trematodes metacercariae were obtained, and they were identified as Clonorchis sinensis (C. sinensis), Metorchis orientalis (M. orientalis), and Metorchis taiwanensis (M. taiwanensis) by morphological and phylogenetic analysis with infection rates of 47.7% (286/600), 15.5% (93/600), and 23.7% (142/600), respectively. Meanwhile, a survey of the three trematodes metacercariae showed that the infection rate of C. sinensis metacercariae was the highest in September, up to 66% (66/100), and the lowest in June at 26% (26/100). The infection rate of M. orientalis metacercariae was the highest in October at 26% (26/100) and the lowest in June at 5% (5/100). The infection rate of M. taiwanensis metacercariae was at its peak in November at 36% (36/100) and the lowest in July at 15% (15/100). The co-infection of metacercariae of C. sinensis and M. taiwanensis was the most common and reached a peak in October, and their infection rate was higher in autumn than in summer. The peak of infection intensity of metacercariae for C. sinensis, M. orientalis, and M. taiwanensis were different: C. sinensis was 24/g in September, M. orientalis was 7/g in October, and M. taiwanensis was 10/g in November. From the above results, it was confirmed that three species of trematodes metacercaria played an important role in infection of second intermediate hosts in Qiqihar region. Studying the morphological characteristics and sequencing the ITS2 gene for a phylogenetic tree of them will be useful for future molecular evolution, biology, and ecology of trematode metacercariae.
Unveiling the influence of persuasion strategies on cognitive engagement: an ERPs study on attentional search
Authors: Xiu Lichao , Chen Xuejiao , Mao Lulu , Zhang Enyu , Yu Guoming
Published: September 2024

The objective of this study was to explore the impact of different persuasive strategies, as delineated in the Elaboration Likelihood Model (ELM), on attentional processes using event-related potentials (ERPs).

Introduction

This study aimed to investigate how central versus peripheral persuasion methods, delivered through rational and emotional persuasion strategies, influence cognitive engagement and information processing during visual search tasks.

Methods

Participants were allocated into four groups based on the media type (video vs. text) and the persuasion route (central vs. peripheral). The early and late stages of attentional processing were examined through the N1, P2, and P3 ERP components.

Results

The results demonstrated a pronounced N1 amplitude in response to text-based peripheral persuasion, indicating enhanced early attentional engagement. Additionally, parallel search tasks revealed a larger P3 amplitude for central versus peripheral routes, suggesting significant cognitive resource allocation during tasks requiring higher attention.

Discussion

These findings underscore the nuanced role of persuasive strategies in modulating attentional resources and cognitive processing. The study offers insights into designing more effective communication messages and highlights the potential for tailored persuasion approaches to influence audience engagement and information processing, with implications for public health campaigns and beyond.
Characterizing the adult zebrafish model of Parkinson’s disease: a systematic review of dynamic changes in behavior and physiology post-MPTP administration
Authors: Razali Khairiah , Kumar Jaya , Mohamed Wael M. Y.
Published: September 2024

Introduction

Adult zebrafish are increasingly used in Parkinson’s disease (PD) research due to their well-characterized dopaminergic system. Among the toxin-based models, the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is widely utilized to induce parkinsonism in adult zebrafish. Therefore, this review presents an overview of the procedures and the dynamic changes in behavior and physiology observed in the adult zebrafish PD model following a single intraperitoneal injection of MPTP.

Methods

A systematic literature search in the PubMed and Google Scholar databases was conducted to identify relevant articles. Of the 165 articles identified, 9 were included in this review. These chosen articles are original works published before March 2024, all of which utilized adult zebrafish induced with MPTP as the model for PD. Other articles were excluded based on factors such as limited relevance, utilization of zebrafish embryos or larvae instead of adults, and variations in MPTP deliveries.

Results

Studies indicated that the ideal model entails the utilization of mixed gender zebrafish aged between 4 and 6 months from the wild-type strain. The acceptable MPTP doses ranges between 20 μg/g (lowest) and 225 μg/g (highest) and doses above 292 μg/g are lethal. Furthermore, noticeable parkinsonian symptoms appear 1 day after administration and persist for more than 1 week.

Discussion

Mitochondrial dysfunction precedes dopaminergic neurodegeneration within this experimental regime. A single administration of MPTP effectively induces PD in adult zebrafish. This study aids in crafting the adult zebrafish PD model, outlining the progressive behavioral and physiological changes ensuing from MPTP administration.
Mendelian randomization provides causal association between COVID-19 and thyroid cancer: insights from a multi-cancer analysis
Authors: Li Shuhong , Du Zedong , Ma Hui , Cai Liang , Liu Xiao , He Jie
Published: September 2024

Since the onset of the COVID-19 pandemic, the SARS-CoV-2 virus has caused over 600 million confirmed infections and more than 6.8 million deaths worldwide, with ongoing implications for human health. COVID-19 has been extensively documented to have extrapulmonary manifestations due to the widespread expression of necessary ACE2 receptors in the human body. Nevertheless, the association between COVID-19 and cancer risk remains inadequately explored. This study employs Mendelian randomization (MR) methods to examine the causal relationship between genetic variations associated with COVID-19 and the risk of developing cancer. The findings indicate that COVID-19 has negligible impact on most cancer risks. Interestingly, a higher COVID-19 impact is associated with a decreased risk of thyroid cancer. In summary, our findings demonstrate a genetic correlation between COVID-19 and thyroid cancer, contributing to our understanding of the interplay between COVID-19 and cancer risk.
Key characteristics of carcinogens meet hallmarks for prevention-cutting the Gordian knot
Authors: Senga Sasi S. , Bisson William H. , Colacci Annamaria
Published: September 2024

The complexity of cancer requires a comprehensive approach to understand its diverse manifestations and underlying mechanisms. Initially outlined by Hanahan and Weinberg in 2000 and updated in 2010, the hallmarks of cancer provide a conceptual basis for understanding inherent variability in cancer biology. Recent expansions have further elucidated additional hallmarks, including phenotypic plasticity and senescent cells. The International Agency for Research on Cancer (IARC) has identified the key characteristics of carcinogens (KCCs) to evaluate their carcinogenic potential. We analyzed chemicals of concern for environmental exposure that interact with specific receptors to induce genomic instability, epigenetic alterations, immune suppression, and receptor-mediated effects, thereby contributing to chronic inflammation. Despite their varying degrees of carcinogenicity, these chemicals have similar KCC profiles. Our analysis highlights the pivotal role of receptor binding in activating most other KCCs, underscoring their significance in cancer initiation. Although KCCs are associated with early molecular or cellular events, they do not encompass processes directly linked to full cellular malignancy. Thus, there is a need to integrate clear endpoints that anchor KCCs to the acquisition of a complete malignant phenotype into chemical testing. From the perspective of toxicology and cancer research, an all-encompassing strategy that incorporates both existing and novel KCCs and cancer hallmarks is essential to enable the targeted identification of prevalent carcinogens and facilitate zone-specific prevention strategies. To achieve this goal, collaboration between the KCC and cancer hallmarks communities becomes essential.
Development and collaborative validation of an event-specific quantitative real-time PCR method for detection of genetically modified CC-2 maize
Authors: Long Likun , Zhao Ning , Li Congcong , He Yuxuan , Dong Liming , Yan Wei , Xing Zhenjuan , Xia Wei , Ma Yue , Xie Yanbo , Liu Na , Li Feiwu
Published: September 2024

As one of the developed genetically modified (GM) maize varieties in China, CC-2 has demonstrated promising commercial prospects during demonstration planting. The establishment of detection methods is a technical prerequisite for effective supervision and regulation of CC-2 maize. In this study, we have developed an event-specific quantification method that targets the junction region between the exogenous gene and the 5’ flanking genomic DNA (gDNA) of CC-2. The accuracy and precision of this method were evaluated across high, medium, and low levels of CC-2 maize content, revealing biases within ±25% and satisfactory precision data. Additionally, we determined the limits of quantification of the method to be 0.05% (equivalent to 20 copies) of the CC-2 maize. A collaborative trial further confirmed that our event-specific method for detecting CC-2 produces reliable, comparable, and reproducible results when applied to five different samples provided by various sources. Furthermore, we calculated the expanded uncertainty associated with determining the content level of CC-2 in these samples.