bluuebunny/crossref_metadata_2025 huggingface dataset:
Modeling of a hydrogen storage tank charging process
Authors: Milewski Jaroslaw , Szczesniak Arkadiusz , Dybiński Olaf , Szałek Andrzej
Published: December 2023

The paper presents a 0-D model of a hydrogen storage tank which is calibrated based on available experimental data. The results obtained are used for operation estimates of higher volume tanks. Increased volume should make hydrogen storage easier, and additional improvements can be made by appropriate selection of the inlet valve and thicker tank walls. It seems justifiable to increase both operating and filling pressures, due to the relatively small energy profits and much more complex charging process. Based on the energy balance, the charging process is endothermic. Neither Joule-Thomson heat nor kinetic energy of the hydrogen discharged allow one to obtain the high temperature reported. There is no experimental data with adequate quality to validate a high-volume storage hydrogen tank. Since the available data correspond to small size tanks and frequently contain contradictions, further experimental investigations are needed in the field.
The protective effect of fluoxetine on hippocampal oligodendrocytes in AD mice: a potential mechanism involving S100B
Authors: Zhang Yi , Jiang Lin , Tang Yong , Chen Weixian , Chao Feng-lei
Published: December 2023

Fluoxetine (FLX) plays a crucial role in delaying the progression of Alzheimer's disease (AD) and opens up new avenues for investigating the mechanisms of AD. Previous research has shown that FLX has a protective effect on oligodendrocytes in the hippocampus of transgenic AD mice. However,the mechanism underlying this effect remains unclear. In this study, we treated 8-month-old APP/PS1 transgenic mice with FLX for 10 weeks and examined the behavioral changes, the levels of S100B protein, the numbers of hippocampus oligodendrocytes and the co-localization of S100B in oligodendrocytes and astrocytes in the hippocampus. Furthermore, we analyzed the damaging effects of exogenous S100B on an oligodendrocyte cell line in vitro and investigated whether fluoxetine could reverse these damages. Our findings demonstrate that FLX delays the decline of hippocampus-dependent spacial learning and memory abilities and the loss of hippocampal oligodendrocytes in AD mice. We also observed a positive correlation between the total number of hippocampal oligodendrocytes and the hippocampal volume. Additionally, FLX reduces hippocampal S100B levels and the expression of S100B in both astrocytes and oligodendrocyte progenitor cells in AD mice. Our cell-based experiments indicate that FLX prevents S100B-induced impairments in oligodendrocyte differentiation and maturation. Moreover, the protective effect of FLX may be associated with the preservation of mitochondrial autophagy and the upregulation of transcription and differentiation factors. Overall, our results highlight the potential mechanisms underlying the protective effect of fluoxetine on S100B-induced impairment of oligodendrocyte differentiation and maturation in AD, and propose a new target for the prevention and treatment of AD.
PREVALENCE OF BURNOUT AMONG HEALTHCARE PROFESSIONALS: A SURVEY AT FORTPORTAL REGIONAL REFERRAL HOSPITAL
Authors: Batanda Ian
Published: December 2023

The work environment in most hospitals is characterized by activities that are strenuous both physically and mentally. These can result in physical and mental exhaustion, which can lead to burnout if not adequately addressed. Burnout among healthcare professionals can negatively affect their clinical decision-making, quality of communication with patients and colleagues as well as their ability to cope with work-related pressure, and ultimately affect the quality of care and patient outcomes. The inclusion of burnout in the 11th revision of the International Classification of Diseases (ICD-11) as an occupational phenomenon indicates that it is an issue of concern in the workplace for which people may need professional attention.
Aim of the study
The aim was to estimate the prevalence of burnout among healthcare professionals at Fort Portal Regional Referral Hospital and to evaluate the linear relationship between the age of workers, their work duration at the hospital, and their burnout score. The possible impact on patient care and the factors contributing to burnout were also evaluated.
Methods:
The study was a descriptive cross-sectional online survey. Participants were selected from the hospital WhatsApp group and invitations to participate were sent to their individual in boxes. Burnout was assessed using the Copenhagen Burnout Inventory.
Results:
Generally, burnout scores ranged from 16% to 86%, with an overall mean burnout score of 57.4%. The notable factors contributing to burnout included imbalances in duty allocation, physically strenuous work, and resource constraints.
Conclusion:
Burnout of varying levels is prevalent across all carders in the hospital, although most healthcare professionals experience moderate burnout. Most of the factors contributing to burnout are within the scope of hospital leadership to address. The possible impact on staff performance and patients’ clinical outcomes is speculative, and additional studies are required.
Roles of Lysine-63-linked ubiquitination on Hif-1α in cell fate decisions between cell proliferation and apoptosis under cadmium effects in epithelial cells
Authors: Chargui Abderrahmen , Belaid Amine , Hashem Abeer , Al-Hazzani Amal A. , Abd_Allah Elsayed Fathi , Hammami Imen , Nahdi Afef , Marzougui Salem , Hofman Paul , Elmay Michèle , Mograbi Baharia
Published: December 2023

Lysine-63-linked ubiquitination -, i.e., The conjugation of a chain of ubiquitins linked through lysine63 has emerged as a key mechanism regulating signal transduction pathways. Although critical, very little information is currently available about how subversion of lysine 63 ubiquitination might contribute to cancers and inflammatory diseases. The present study provides evidence that cadmium, a carcinogenic and toxic substance released into the environment, is a powerful activator of lysine-63 ubiquitination. Indeed, cadmium induces the accumulation of lysine-63-polyubiquitination proteins. Importantly, cadmium-induced ubiquitination does not stem oxidative damage or proteasome impairment. Rather, we demonstrate that cadmium not only activates Lysine 63 ubiquitination but also amplifies its accumulation by overloading the capacity of the autophagy pathway, thus promoting endoplasmic reticulum stress and cell death. At the molecular level, cadmium-induced ubiquitination is correlated with the stabilization of hypoxia inducible factor-1-alpha, a transcription factor. Strikingly, prolonged cell exposure to high cadmium concentrations induces exaggerated lysine-63 ubiquitination that fosters aggresome formation, thus precluding this protein from interacting with its downstream nuclear targets. We therefore propose that the aberrant activation of lysine-63 ubiquitination by the carcinogen cadmium could promote cell proliferation and inflammation at low levels, while high levels lead to cell death.
Investigating the Potential of dietary additives, Spirulina platensis and Curcumin Nanoparticles in Nile Tilapia Fingerlings: A Comprehensive Analysis of Growth, Health, and Immune Function
Authors: Eissa El-Sayed Hemdan , Khattab Marwa S. , Elbahnaswy Samia , Elshopakey Gehad E. , Alamoudi Muna O. , Aljarari Rabab M. , Munir Mohammad Bodrul , Kari Zulhisyam Abdul , Naiel Mohammed A.E.
Published: December 2023

A total of 180 Nile tilapia fingerlings (10 ± 0.5 g) were separated into three groups (n = 60), including a control group and two experimental groups supplemented withSpirulina platensis(SP; 5 g.kg-1) and curcumin nanoparticles (Cu-NPs; 30 mg.kg-1), respectively. After a 56-day feeding study, an evaluation of growth performance, hematological factors, antioxidant activity, biochemical and immunological characteristics, and histological modifications were conducted. The results revealed that the SP- and Cu-NPs supplements significantly improved growth indices, carcass features and biochemical features in both experimental groups compared to the control. Furthermore, the activities of digestive enzymes, comprising amylase, lipase, and protease, were significantly increased in the SP and Cu-NPs groups, unlike the control group. Additionally, supplementation with Cu-NPs and SP significantly enhanced the antioxidant state, as exhibited by increased glutathione peroxidase (GPx) and superoxide dismutase (SOD) activity and decreased activity of malondialdehyde (MDA). The immune response was also significantly improved, with higher serum IgM and lysozyme activity in the SP and Cu-NPs treatments. Therefore, this study provides evidence that dietary supplementation with Cu-NPs and SP efficiently enhances the activity of digestive enzymes, antioxidant capacity, growth and performance, hepatoprotective capabilities, histopathology, and immune responses of Nile tilapia fingerlings.
An earlier introduction of bow-and-arrow in southernmost Patagonia? firing experiments, survival curve models, and geometric morphometric methods to evaluate the use of Fell IV points as arrowheads
Authors: Charlin Judith , Cardillo Marcelo , Corada Juan Pablo Donadei , Arriaga Lucas Cheme , Moreno Eduardo , Shott Michael
Published: December 2023

In southernmost continental Patagonia (52º S) the introduction of the bow-and-arrow is traditionally associated with the appearance of the small Fell V or "Ona" points around 700 years ago. Earlier and larger Fell IV or "Patagonian" points were considered spear points. Our study focuses on a firing experiment with replicas of the Fell IV points hafted onto arrows that were repeatedly fired and resharpened until the end of their use-life. After each firing, surface impact (bone or meat), macrofractures, and the need for resharpening were recorded. Additionally, size measurements and plan-view photographs of each point at the beginning and end of the experiment, as well as after each resharpening, were documented to further analysis of size and shape variations. Survival-curve models were used to estimate the probability of point survival based on the number of shots and resharpenings endured. By employing landmark-based geometric morphometrics, blade-shape variations throughout replicas' use-life were compared to Fell IV and V archaeological points morphology. The experimental results exhibited the functional efficiency of Fell IV replicas used as arrowheads, with a variable but extended use-life averaging 21 shots and two resharpenings. Shape similarity is observed in the comparison of both experimental and archaeological point datasets. Therefore, an earlier adoption of bow-and-arrow technology in southernmost continental Patagonia is suggested according to experimental data and shape analysis. This technological innovation might be associated with the macroregional climate variations that affected in different ways the subsistence and settlement patterns of Patagonian human populations during the last ca. 2000 years BP.
Reducing variation in the quality of long covid care: Lessons from a national quality improvement collaborative and multi-site ethnography
Authors: Greenhalgh Trisha , Darbyshire Julie , Lee Cassie , Ladds Emma , Ceolta-Smith Jenny
Published: December 2023

Context
Long covid (post covid-19 condition) is a complex condition with diverse manifestations and uncertain prognosis. There is wide variation in how patients are investigated and managed. There have been calls for formal quality standards so as to reduce a so-called “postcode lottery” of care. We aimed to examine the nature of quality in long covid care and reduce unwarranted variation in care provided by long covid services.
Methods
In a mixed-method study (2021-2023), we ran a quality improvement collaborative across 10 UK sites. We also gathered data on the origins and current context of each clinic, interviewed staff and patients, and observed 12 clinics (52 consultations) and 34 multidisciplinary team (MDT) meetings (230 patient cases). Data collection and analysis were informed by relevant lenses from clinical care (e.g. evidence-based guidelines), improvement science (e.g. quality improvement cycles, reducing unwarranted variation) and philosophy of knowledge.
Results
The collaborative made progress towards standardizing assessment and management in some topics, but much variation remained. Clinics had different histories and path-dependencies, occupied a different place in their healthcare ecosystem and served a varied caseload including (in most clinics) a high proportion of patients with comorbidities. Dimensions of quality prioritized by patients related to the service (e.g. accessibility, ease of navigation), and human qualities of staff (e.g. attentiveness, compassion). A key route to quality long covid care was when local MDTs deliberated on unusual, complex or challenging cases for which evidence-based guidelines provided no easy answers. In such cases, collective learning occurred through idiographic reasoning, in which practitioners build lessons from the particular to the general. This contrasts with the nomothetic reasoning implicit in evidence-based guidelines, in which reasoning is assumed to go from the general (e.g. findings of clinical trials) to the particular (management of individual patients).
Conclusion
Not all variation in long covid services is unwarranted. Largely because long covid’s manifestations are so varied, universal ‘evidence-based’ standards are hard to define and implement. In this complex condition, quality improvement resources may be better spent supporting team-based learning locally than attempting to standardize care across widely differing services.
Trial registration
NCT05057260, ISRCTN15022307.
Unravelling stakeholder narratives on nature-based solutions for hydro-meteorological risk reduction—a multi-site case study in Southeast and Central Europe
Authors: Han Sungju , Luo Anran
Published: December 2023

This study delves into the landscape of stakeholder narratives concerning the implementation of nature-based solutions (NBS) for mitigating hydro-meteorological risks across five European river basin sites. Employing a hybrid approach of Q-methodology (N = 103) and narrative analysis, we identified four key narratives: optimist, sceptic, reformist, and pragmatist. These narratives reflect a spectrum of stakeholder values and attitudes towards NBS, from enthusiastic support to cautious scepticism. The optimists are hopeful about the multifaceted benefits of NBS, while sceptics raise concerns over its practicality and evidence of effectiveness. Reformists advocate for systemic improvements and transparent processes, whereas pragmatists emphasise tangible, immediate benefits and cost-effectiveness. Our findings underscore the importance of recognising and integrating this diversity of perspectives to develop NBS strategies that are resonant with stakeholders, thereby enhancing project acceptance and resilience against hydro-meteorological risks. Our findings provide an in-depth understanding of stakeholder views, contributing to a practical framework that aligns NBS projects with prevailing narratives. This comprehensive panorama of stakeholder perspectives offers valuable guidance for policymakers, practitioners, and researchers, aiding in the navigation of the complex landscape of NBS implementation. It bridges the gap between academic insights and real-world applications, underscoring the critical role of stakeholder engagement in effective risk management and sustainable environmental strategies.
Cineclubismo: a experiência do Cineclube Eduardo Coutinho
Authors: SILVA Jean Carllo de Souza , PONSONI Samuel , SETTE Bruno de Moura , MARTINS Luigy Gabriel Resende
Published: December 2023

O objetivo deste relato de experiência é discutir a relevância pedagógica, mas, sobretudo, social, do cineclubismo para a formação de estudantes do campo da Comunicação Social. Para tanto, se discute, em específico, a proposta de cineclube praticada pelo “Cineclube Eduardo Coutinho”, ação extensionista voltada especialmente para exibição de cinema documentário nacional. O projeto, realizado entre julho e dezembro de 2022 em uma universidade localizada em uma cidade do interior de Minas Gerais, exibiu oito documentários de longa-metragem em sessões abertas seguidas de discussões acerca das temáticas e da linguagem cinematográfica adotadas por cada um deles. Com isso, acredita-se que o público participante das sessões teve contato com temas candentes de nossa época e da realidade social brasileira e, sobremaneira, atentou para as múltiplas possibilidades de representá-la em audiovisual.
Financial Reporting Quality During COVID-19 Pandemic: International Evidence
Authors:   Faculty of Accountancy, Universiti Teknologi MARA, Kampus Sungai Petani, 08400 Merbok, Kedah, Malaysia, Ismail Wan Adibah Wan , Ariff Akmalia M ,   Faculty of Business, Economics and Social Development, Universiti Malaysia Terengganu, 21030 Kuala Nerus, Terengganu, Malaysia, Kamarudin Khairul Anuar ,   School of Business, University of Wollongong in Dubai, UOWD Building, Dubai Knowledge Park, P.O. Box 20183 Dubai, United Arab Emirates, Adnan Nur Shaida Mohd ,   Radicare (M) Sdn Bhd, Level 13, Wisma UOA Damansara II, No 6, Jalan Changkat Semantan, Damansara Heights, 50490 Kuala Lumpur, Malaysia
Published: December 2023

This paper examines the effect of the COVID-19 pandemic on financial reporting quality proxied by earnings conservatism and value relevance of accounting information. Our final sample consists of 10,510 firm-year observations from 29 countries with a balanced number of 5,255 observations for pandemic and pre-pandemic periods. The results show that during the pandemic, the financial statements of companies with a financial year end of 31 March 2020 have different qualities than those in the pre-pandemic period. Lower earnings conservatism is demonstrated in the pandemic period compared to the pre-pandemic period, supporting the argument that business tends to slow the recognition of bad news as the pandemic starts. The value relevance of accounting information declined in the pandemic period, primarily affected by the reduced value relevance of the book value of equity. The findings of this study can help investors evaluate the quality of accounting information and make smarter investment decisions, especially when most companies are in financial trouble.
Determination of Heavy Metals in Root and Shoot of Durum Wheat, Plant Soil: Translocation and Bioaccumulation Factor
Authors: Berrettoni Mario , Zamponi Silvia , Conti Paolo , Fattobene Martina , Liu Fuyong , Aborah Martin
Published: December 2023

Heavy metals are uptake by the soil, transfer and accumulate in the various parts of durum wheat plant. The exposure of wheat crops to heavy metals poses threat to their physiological growth and human health through consumption. The study aimed at finding the concentration of heavy metals in durum wheat varieties, transfer and bioaccumulation ability, and effect of organic and conventional farming on heavy metals. The wheat samples (under organic and conventional farming) were randomly sampled at tillering, jointing, and grain filling stage. They were digested with ultra-microwave and analyzed with inductively coupled plasma. The results showed that Zn emerged as the highest concentration in the soil, root, and shoot of all wheat samples and mostly followed by Cr, Cu, Pb, and Cd. With few instances, an order of Cu>Zn>Cd>Cr>Pb>As translocation and accumulation was observed. Statistical study (α .05 and CI of 95%) revealed conventional farming increased heavy metals in the soil. Therefore, organic farming should be adopted to prevent heavy metal contamination of wheat plants and higher food chain.
A symmetry algebra in double-scaled SYK
Authors: Lin Henry W. , Stanford Douglas
Published: December 2023

The double-scaled limit of the Sachdev-Ye-Kitaev (SYK) model takes the number of fermions and their interaction number to infinity in a coordinated way. In this limit, two entangled copies of the SYK model have a bulk description of sorts known as the “chord Hilbert space”. We analyze a symmetry algebra acting on this Hilbert space, generated by the two Hamiltonians together with a two-sided operator known as the chord number. This algebra is a deformation of the JT gravitational algebra, and it contains a subalgebra that is a deformation of the \mathfrak{sl}_2𝔰𝔩2 near-horizon symmetries. The subalgebra has finite-dimensional unitary representations corresponding to matter moving around in a discrete Einstein-Rosen bridge. In a semiclassical limit the discreteness disappears and the subalgebra simplifies to \mathfrak{sl}_2𝔰𝔩2, but with a non-standard action on the boundary time coordinate. One can make the action of \mathfrak{sl}_2𝔰𝔩2 algebra more standard at the cost of extending the boundary circle to include some “fake” portions. Such fake portions also accommodate certain subtle states that survive the semi-classical limit, despite oscillating on the scale of discreteness. We discuss applications of this algebra, including sub-maximal chaos, the traversable wormhole protocol, and a two-sided OPE.
Parametric study of coagulant recovery from water treatment sludge towards water circular economy
Authors: Shawal N. B. M. , Razali N. A. , Hairom N. H. H. , Yatim Norhafiza Ilyana I. , Rasit N. , Harun M. H. C. , Kasan N. , Hamzah Sofiah
Published: December 2023

This study aims to recover the used coagulants from two water treatment plants via acidification technique. The water treatment sludge (WTS) was acidified with sulfuric acid (H2SO­4) at variable normalities (0.5, 1, 1.5, 2.0 and 2.5 N). The surface morphology and functionalities of both recovered coagulants were analysed using scanning electron microscopy (SEM) and Fourier-transform infrared spectroscopy (FTIR). The performance of recovered coagulants was tested for turbidity removal in surface water treatment at different coagulant dosages and pH. It was found that the optimum normality of H2SO4 for recovered alum was 1.5 N, where 66% turbidity removal was recorded. The recovered PAC treated with 1.0 N H2SO4 indicated high turbidity removal percentage, which was 50.5%. The turbidity removal increased with increasing coagulant dosage. More than 80% turbidity removal was achieved with 40 mg/L dosage of recovered alum and recovered PAC. Maximum removal (85%) was observed with 50 mg/L dosage of recovered alum. For commercial coagulant, the turbidity removal was higher, with a difference of up to 6% in favor of recovered alum. The potential reuse of coagulants can be explored in order to reduce the operating costs and promotes the reduction of WTS disposal.
UTILIZAÇÃO DAS TECNOLOGIAS NO PROCESSO DE ENSINO-APRENDIZAGEM EM TEMPOS DE PANDEMIA
Authors: Munay Dantas Frutuoso Camilla , Ferreira Cavalcante Ilane , Das Chagas Lemos Elizama
Published: December 2023

A presente pesquisa tem como objetivo compreender, por meio de um estado da arte, o que se produziu acerca do uso das Tecnologias Digitais da Informação e Comunicação (TDIC) aplicadas à educação no período da pandemia COVID-19, com ênfase nas tecnologias utilizadas no ensino remoto. A pesquisa foi desenvolvida na base de dados de repositórios da CAPES e da Scielo. Para a fundamentação teórica utilizamos autores de referência na área, tais como: Lemos e Lévy (2010), Lévy (1999), Mill (2018) e Sancho (2006). Nos repositórios foram encontrados periódicos sobre como foi o uso da TDIC durante a pandemia publicados no período entre 2020 e 2021 no Brasil, apresentando os espaços e locais onde essas pesquisas foram realizadas, também como os temas abordados. Foram encontradas 15 pesquisas sobre a temática, duas internacionais e as demais no âmbito nacional. Essas pesquisas refletem sobre as produções acadêmicas desenvolvidas no Brasil e no exterior, nenhum dos estudos encontrados relatam sobre a formação ou experiência dos docentes sobre o uso da TDIC no âmbito da Educação Profissional.
“Eu me chamo ...”
Authors: Ferreira Lúcia Gracia
Published: December 2023

Este artigo foi desenvolvido a partir das narrativas e do método das histórias de vida, e refere-se às pesquisas realizadas nos anos de 2009 e 2012, desenvolvidas no âmbito do Programa de Pós-Graduação em Educação e Contemporaneidade da Universidade do Estado da Bahia e do Programa de Pós-Graduação em Educação, da Universidade Federal de São Carlos, ambas pesquisas realizadas com professores rurais, na Bahia. As narrativas dos colaboradores permitiram o desenvolvimento deste trabalho aqui apresentado, cujo objetivo incide em analisar o que são revelados, referente a contextos e histórias de vida-formação, através dos nomes escolhidos (pseudônimos) pelos professores rurais, expressos nas narrativas (auto)biográficas. Na pesquisa, doze professores foram identificados pelos nomes escolhidos por eles e essa escolha remete a algum lugar ou papel do aspecto da vida e/ou da formação. Conforme ressaltado na literatura, tudo que é narrado é importante e essas escolhas estão ligadas à família, ao contexto, às lembranças da infância, aos gostos, ao jeito de ser e a outras questões. Assim, vale ressaltar a contribuição desse trabalho, pois as narrativas expressam aspectos da identidade e o nome é parte disso. Esses nomes narrados e contextualizados, e seus sentidos e significados, remeteram a uma discussão sobre identidade e formação desses professores rurais.
A Esquizofrenia e o Cuidador - os problemas da Reinserção Social
Authors: Freitas Gabriele Soares
Published: December 2023

Objetivo geral: Buscar os problemas causados à saúde do cuidador familiar da pessoa com esquizofrenia. Materiais e Métodos: Utilizou-se como método a pesquisa bibliográfica, do tipo descritivo e abordagem qualitativa. Resultados: Foi possível encontrar o total de 6 artigos, os quais seriam utilizados para a discussão. Diante da leitura dos mesmos, foi alcançada a resposta ao questionamento da pesquisa, tendo como foco a busca dos problemas ocasionados ao cuidador familiar ao lidar com a pessoa com Esquizofrenia. Discussão: Pode-se observar que o cuidado à pessoa com esquizofrenia acarreta em alguns problemas na vida do cuidador familiar, afetando tanto a parte física, como a emocional, econômica e social. Considerações finais: Ainda que tenha alcançado a resposta à problemática do estudo, foi observada a necessidade de mais estudos focados nos efeitos da reinserção social sobre a vida dos familiares e também, a importância da atuação do enfermeiro no ambiente domiciliar, observando não somente as queixas da pessoa com transtorno mental, mas também, de quem cuida dessa pessoa no núcleo familiar.
Palavras-Chave: Esquizofrenia; Cuidadores; Saúde Mental.
Competências do enfermeiro no acolhimento com classificação de risco em uma unidade de emergência
Authors: Mendonça Amanda Ribeiro , Queluci Gisella de Carvalho , Dias Suelem Frian Couto , Souza Vinícius Rodrigues de
Published: December 2023

Introdução: o acolhimento com classificação de risco é utilizado como uma ferramenta para melhorar os atendimentos das emergências propondo que o cliente seja acolhido e atendido com base em critérios de avaliação predefinidos na consulta de enfermagem, buscando garantir a humanização da assistência, acessibilidade e atendimento mais acolhedor e menos excludente. Objetivo: discutir as competências necessárias aos enfermeiros para o acolhimento do cliente no serviço de emergência e a classificação de risco a partir de uma abordagem situacional. Método: recorte de dissertação de mestrado, realizada a partir de estudo descritivoexploratório com abordagem qualitativa realizado no serviço de emergência adulto de um hospital do interior do estado do Rio de Janeiro. Foram realizadas entrevistas semiestruturadas concomitantemente a observação não participante e registro em diário de campo. As entrevistas foram gravadas, transcritas e analisadas utilizando a análise temática.Resultados: para atuação na classificação de risco, os enfermeiros destacaram competências como: realização de procedimentos técnicos essenciais calçados em saberes científicos, proatividade, comunicação, relacionamento interpessoal e liderança. Observou-se que, apesar de os enfermeiros possuírem desempenho assistencial compatível à situação clínica apresentada pelo cliente, foi relatada a necessidade de maior suporte institucional relacionado com carga horária, recursos humanos e instalações físicas. Educação permanente e capacitação da equipe multidisciplinar foram apontadas como ponto crítico para a tomada de decisões. Considerações finais: algumas competências são intrínsecas à pessoa do enfermeiro e acentuadas na prática profissional, mas devem estar associadas para garantir a qualidade da assistência e minimizar a fragilidade do fluxograma de atendimento.
Palavras-Chave: Acolhimento; Competência Profissional; Enfermagem em Emergência.
Cuidados do enfermeiro a recém-nascidos críticos no cateterismo epicutâneo auxiliado por ultrassonografia
Authors: Oliveira Márcia Farias de , Silvino Zenith Rosa , Vilar Andréa Maria Alves , ´Souza Cláudio José de
Published: December 2023

Resumo
Introdução:  Estudo de revisão, primeira fase de uma  tese de doutorado,  realizado com o  objetivo de mapear evidências atuais que contemplem cuidados do enfermeiro a recém-nascidos críticos submetidos a cateterismo epicutâneo com ultrassonografia à beira do leito. Materiais e Métodos: Revisão de escopo, seguindo metodologia do Joanna Briggs Institute, com protocolo registrado na Open Science Framework. As buscas foram realizadas em cinco bases de dados e no Google Scholar, entre março e maio de 2022. A análise das citações dos estudos capturados foi um recurso utilizado para aumentar a amostra. Resultados: Os cuidados do enfermeiro que emergiram dos 22 estudos selecionados, publicados entre 2017 e 2022, em diversos países, foram apresentados por meio de quadro sinóptico, dividido em gestão do cuidado e  cuidados diretos ao  recém- nato nas fases de pré-inserção, inserção e manutenção e remoção do cateter. Discussão: A discussão narrativa realizada foi focada em recomendações  atuais, derivadas da incorporação do ultrassom portátil ao processo estudado, tais como medidas suplementares para manutenção de barreira asséptica máxima, visualização de vasos mais aprofundados,  escolha do cateter mais adequado ao vaso escolhido  e confirmação da  localização da  ponta do cateter  a partir de protocolos específicos, limitados. Considerações finais: O mapeamento realizado possibilitou a estratificação, baseada em evidências atuais, do cuidado do enfermeiro neonatal em cateterismo epicutâneo  ecoassistido,  e tem potencial  tanto para  contribuir no  desenvolvimento de estudos futuros quanto para auxiliar nos cenários de prática, notadamente naqueles que visam incorporar o ultrassom em seus protocolos de enfermagem para estabelecimento de acessos venosos.
Descritores: Cateterismo Venoso Central; Ultrassonografia de Intervenção; Recém-Nascido; Unidades de Terapia Intensiva Neonatal; Cuidados de Enfermagem
influência da dieta da gestante na preferência alimentar e saúde bucal do bebê: revisão integrativa
Authors: Barbosa Carla Cristina Neves , Duarte Danilo Antonio
Published: December 2023

Objetivo: Avaliar a influência da dieta de gestantes sobre a preferência alimentar do bebê e por consequência o reflexo para a  saúde bucal do mesmo. Métodos: Trata-se de revisão integrativa da literatura (RIL), realizada em oito bases de dados, utilizando os descritores: Dieta na gravidez, Gustação, Sabor, Odontopediatria e Aleitamento Materno combinados com os operadores booleanos AND e OR. Incluíram exclusivamente artigos que respondiam à questão norteadora, nos idiomas inglês, português e espanhol. Excluíram artigos duplicados, teses, cartas e guidelines. Resultados: Inicialmente, identificaram-se 1340 artigos, restando 15 artigos após observação dos critérios de elegibilidade. Esses resultados expressam uma lacuna de conhecimento na temática, indicando notável premência de investigações que possam redundar em evidências acerca do estado atual do assunto. Considerações finais: A RIL permite inferir uma associação entre dieta da gestante, preferência alimentar e saúde bucal do bebê. Assim, é relevante ampliar e estimular programas de educação e segurança alimentar voltados para gestantes, visando reduzir vulnerabilidades do recém-nascido, abordando especificamente a saúde bucal.
Palavras-Chave: Alimentação na Gravidez; Paladar; Odontopediatria; Aleitamento Materno; Saúde Bucal.
Exploration of the Mechanism of Kaempferol in the Treatment of Cervical
Cancer-based on Metabolomics and Network Pharmacology
Authors: Cao Dong-Min , Liu Tao
Published: December 2023

Background:

Cervical cancer is a prevalent malignancy among women globally.

Objective:

We aimed to uncover the mechanism of action of kaempferol in the treatment of cervical cancer using
an integrated approach that combines metabolomics with network pharmacology.

Methods:

Initially, we investigated the specific metabolites and potential pathways influenced by kaempferol
in the pathological progression of cervical cancer, employing UHPLC-Q-Orbitrap MS metabolomics. In addition,
network pharmacology analysis was performed to ascertain the pivotal targets of kaempferol in the context
of CC therapy.

Results:

Metabolomics analysis indicated that the therapeutic effect of kaempferol on cervical cancer is primarily
associated with 11 differential metabolites and 7 metabolite pathways. These pathways include arginine
and proline metabolism, the tricarboxylic acid cycle, phenylalanine, tyrosine, and tryptophan biosynthesis, fatty
acid biosynthesis, glycerophospholipid metabolism, pantothenate and CoA biosynthesis, and tyrosine
metabolism. Additionally, kaempferol was found to regulate 3 differential metabolites, namely palmitic acid,
citric acid, and L-tyrosine, by directly targeting 7 specific proteins, including AKR1B1, CS, EGFR,
PLA2G1B, PPARG, SLCO2B1, and SRC. Furthermore, molecular docking demonstrated strong binding affinities
between kaempferol and 7 crucial targets.

Conclusion:

This study elucidates the intricate mechanisms by which kaempferol acts against cervical cancer.
Furthermore, this research offers a novel approach to investigating the potential pharmacological mechanisms
of action exhibited by natural compounds.
Synergistic Effect, and Therapeutic Potential of Aqueous Prickly Pear
Extract. In vivo Neuroleptic, Catatonic, and Hypoglycemic Activity
Authors: Benattia Farah Kenza , Arrar Zoheir , Dergal Fayçal , Khabbal Youssef
Published: December 2023

Background:

Prickly pear "Opuntia ficus indica (L.) Mill. "otherwise known as the Indian
fig tree, belongs to the family Cactaceae, and was known as a medicinal plant for its rich source
of bioactive substances.

Objective:

The present work aims to promote prickly pear seeds for traditional therapy by phenolic
profiling and pharmacological tests of aqueous extract.

Method:

An analytical quantification was performed by UV-Visible, and the identification of different
bioactive compounds was done by HPLC-DAD. For pharmacological screening, an in vivo
evaluation of the various tests, neuroleptic activity which consists of testing the recovery reflex;
catatonic activity which is a test to detect catalepsy that can be characterized in animals by the administration
of neuroleptic drugs; and for hypoglycemic activity a test was performed to assess glucose
tolerance.

Results:

The administration of aqueous extract of the prickly pear seeds at a dose (400 mg/kg) allows
a reduction in blood sugar with a maximum decrease of one and a half hours compared to the
control group.

Conclusion:

This work makes it possible to postulate that the extract of prickly pear seeds is associated
with a very interesting antihyperglycemic activity given its high content of phenolic compounds.
Neuroethological Analysis of the Effects of Venom of the Spider Vitalius
Platyomma (Theraphosidae, Theraphosinae) Microinjected into the Lateral
Ventricle of Wistar Rats
Authors: Ribeiro Alessandra Mussi , Estábile Eliane , dos Santos Cardoso Fabrizio , dos Santos Wagner Ferreira , Garcia-Cairasco Norberto
Published: December 2023

Introduction:

Spiders are predators that use their venom to immobilize their prey. These
spider toxins are able to affect the central nervous system of mammals.

Methods:

We hypothesized that venom from the tarantula Vitalius platyomma may induce behavioral
changes in male Wistar rats. To test this hypothesis, the behavioral effects of venom were investigated
after intracerebroventricular microinjection using the neuroethological method (behavioral sequences)
associated with the ETHOMATIC program, evaluating frequency, duration, and strength of statistical
association between pairs (dyads) of behaviors.

Results:

The results obtained in this present study showed that the intracerebral administration of V.
platyomma crude venom provoked a difference in the time of freezing of animals. In addition, animals
showed after the freezing period changes in the exploratory and grooming clusters and additional complex sequences of behaviors such as wild running.

Conclusion:

This study clearly demonstrated the appearance of seizure-like behaviors, similar to audiogenic brainstem-dependent seizures such as those observed in genetically-selected audiogenic strains.
Taking back control of the energy sector? A legal analysis of Brexit and the EU-UK trade and cooperation agreement
Authors: Goldberg Silke
Published: December 2023

This book focuses on the legal consequences of Brexit for the energy sector both in the United Kingdom and in the European Union. In particular, it considers to what extent the EU-UK Trade and Cooperation Agreement (TCA) is adequate for the energy sector post-Brexit by exploring whether the TCA delivers legal certainty,has been effectively implemented, and meets the Brexit objectives. The analysis of these questions leads to several recommendations, for instance in relation to the implementation of the TCA and its extension to new energy technologies.
Social Media Use and Its Concurrent and Subsequent Relation to a Biological Marker of Inflammation: Short-Term Longitudinal Study
Authors: Lee David , Jiang Tao , Crocker Jennifer , Way Baldwin
Published: December 2023

Background

Although many studies have examined the impact of social media use (SMU) on mental health, very few studies have examined the association of SMU with health-relevant biomarkers.

Objective

Addressing this gap, we conducted a short-term longitudinal study examining the link between SMU and C-reactive protein (CRP), a biological marker of systemic inflammation predictive of major depression, chronic diseases, and mortality.

Methods

We measured college students’ weekly amount of SMU for 5 consecutive weeks objectively via the Screen Time app and collected blood samples at baseline and 5 weeks later.

Results

In separate cross-sectional analyses conducted at phase 1 (baseline) and at phase 2 (5 weeks after baseline), objective SMU had a positive, concurrent association with CRP at both time points. Critically, in a longitudinal analysis, more SMU between phase 1 and phase 2 predicted increased CRP between these time points, suggesting that increased SMU led to heightened inflammation during that period.

Conclusions

Although more research is needed to understand why SMU led to higher inflammation, the association between objective SMU and a marker of a biological process critical to physical health presents an intriguing opportunity for future research on social media effects.
Measuring Heart Rate Accurately in Patients With Parkinson Disease During Intense Exercise: Usability Study of Fitbit Charge 4 (Preprint)
Authors: Colonna Giulia , Hoye Jocelyn , de Laat Bart , Stanley Gelsina , Ibrahimy Alaaddin , Tinaz Sule , Morris Evan D
Published: December 2023

BACKGROUND

Parkinson disease (PD) is the second most common neurodegenerative disease, affecting approximately 1% of the world’s population.
Increasing evidence suggests that aerobic physical exercise can be beneficial in mitigating both motor and nonmotor symptoms of the disease.
In a recent pilot study of the role of exercise on PD, we sought to confirm exercise intensity by monitoring heart rate (HR). For this purpose, we asked participants to wear a chest strap HR monitor (Polar Electro Oy) and the Fitbit Charge 4 (Fitbit Inc) wrist-worn HR monitor as a potential proxy due to its convenience.
Polar H10 has been shown to provide highly accurate R-R interval measurements. Therefore, we treated it as the gold standard in this study. It has been shown that Fitbit Charge 4 has comparable accuracy to Polar H10 in healthy participants. It has yet to be determined if the Fitbit is as accurate as Polar H10 in patients with PD during rest and exercise.

OBJECTIVE

This study aimed to compare Fitbit Charge 4 to Polar H10 for monitoring HR in patients with PD at rest and during an intensive exercise program.

METHODS

A total of 596 exercise sessions from 11 (6 male and 5 female) participants were collected simultaneously with both devices. Patients with early-stage PD (Hoehn and Yahr ≤2) were enrolled in a 6-month exercise program designed for patients with PD. They participated in 3 one-hour exercise sessions per week. They wore both Fitbit and Polar H10 during each session. Sessions included rest, warm-up, intense exercise, and cool-down periods.
We calculated the bias in the HR of the Fitbit Charge 4 at rest (5 min) and during intense exercise (20 min) by comparing the mean HR during each of the periods to the respective means measured by Polar H10 (HRFitbit – HRPolar). We also measured the sensitivity and specificity of Fitbit Charge 4 to detect average HRs that exceed the threshold for intensive exercise, defined as 70% of an individual’s theoretical maximum HR. Different types of correlations between the 2 devices were investigated.

RESULTS

The mean bias was 1.68 beats per minute (bpm) at rest and 6.29 bpm during high-intensity exercise, with an overestimation by Fitbit Charge 4 in both conditions. The mean bias of the Fitbit across both rest and intensive exercise periods was 3.98 bpm. The device’s sensitivity in identifying high-intensity exercise sessions was 97.14%. The correlation between the 2 devices was nonlinear, suggesting Fitbit’s tendency to saturate at high values of HR.

CONCLUSIONS

The performance of Fitbit Charge 4 is comparable to Polar H10 for assessing exercise intensity in a cohort of patients with PD (mean bias 3.98 bpm). The device could be considered a reasonable surrogate for more cumbersome chest-worn devices in future studies of clinical cohorts.
Improving the Well-Being of People With Advanced Cancer and Their Family Caregivers: Protocol for an Effectiveness-Implementation Trial of a Dyadic Digital Health Intervention (FOCUSau) (Preprint)
Authors: Hudson Peter , Francis Jill , Cohen Joachim , Kapp Suzanne , De Abreu Lourenco Richard , Beatty Lisa , Gray Kathleen , Jefford Michael , Juraskova Ilona , Northouse Laurel , de Vleminck Aline , Chang Sungwon , Yates Patsy , Athan Sophy , Baptista Shaira , Klaic Marlena , Philip Jennifer
Published: December 2023

BACKGROUND

Advanced cancer significantly impacts patients’ and family caregivers’ quality of life. When patients and caregivers are supported concurrently as a dyad, the well-being of each person is optimized. Family, Outlook, Communication, Uncertainty, Symptom management (FOCUS) is a dyadic, psychoeducational intervention developed in the United States, shown to improve the well-being and quality of life of patients with advanced cancer and their primary caregivers. Originally, a nurse-delivered in-person intervention, FOCUS has been adapted into a self-administered web-based intervention for European delivery.

OBJECTIVE

The aims of this study are to (1) adapt FOCUS to the Australian context (FOCUSau); (2) evaluate the effectiveness of FOCUSau in improving the emotional well-being and self-efficacy of patients with advanced cancer and their primary caregiver relative to usual care control group; (3) compare health care use between the intervention and control groups; and (4) assess the acceptability, feasibility, and scalability of FOCUSau in order to inform future maintainable implementation of the intervention within the Australian health care system.

METHODS

FOCUS will be adapted prior to trial commencement, using an iterative stakeholder feedback process to create FOCUSau. To examine the efficacy and cost-effectiveness of FOCUSau and assess its acceptability, feasibility, and scalability, we will undertake a hybrid type 1 implementation study consisting of a phase 3 (clinical effectiveness) trial along with an observational implementation study. Participants will include patients with cancer who are older than 18 years, able to access the internet, and able to identify a primary support person or caregiver who can also be approached for participation. The sample size consists of 173 dyads in each arm (ie, 346 dyads in total). Patient-caregiver dyad data will be collected at 3 time points—baseline (T0) completed prerandomization; first follow-up (T1; N=346) at 12 weeks post baseline; and second follow-up (T2) at 24 weeks post baseline.

RESULTS

The study was funded in March 2022. Recruitment commenced in July 2024.

CONCLUSIONS

If shown to be effective, this intervention will improve the well-being of patients with advanced cancer and their family caregivers, regardless of their location or current level of health care support.

CLINICALTRIAL

ClinicalTrials.gov NCT06082128; https://clinicaltrials.gov/study/NCT06082128

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/55252
IN VITRO PROTECTIVE EFFECT OF PROTEINS OF TERMINALIA CHEBULA FRUITS ACTION ON INHIBITION OF HEMOLYSIS, PROTEINASE, AND PROTEIN DENATURATION PROCESS
Authors: NG Omkar , Vedamurthy Joshi  , Ramadas Dinesha
Published: December 2023

Objective: The study helps to evaluate the anti-inflammatory activity of Terminalia chebula fruit protein.
Methods: The crude protein extracted from T. chebula fruits was subjected to analysis for its hemolysis inhibitory, proteinase inhibitory, and protein denaturation inhibitory activities.
Results: In the antioxidant property model, the crude protein exhibited an inhibitory activity of 52% compared to 58% and 61% for ascorbic acid and alpha-tocopherol, respectively. In the hemolysis inhibition studies, the crude proteins demonstrated an inhibition of 42.1%. In the protein denaturation inhibitory study, the crude protein showed a maximum inhibition of 28%, while in the proteinase inhibitory studies, it exhibited a maximum inhibition of 43.1%.
Conclusion: The results of the study revealed that the crude proteins possess antioxidant and anti-inflammatory properties in various model systems.
ROLE OF DIFFUSION-WEIGHTED MAGNETIC RESONANCE IMAGING FOR BRAIN TUMOR CHARACTERIZATION
Authors: Hitawala Rumana , Kundu Ravinder K , Shams Sabina
Published: December 2023

Objectives: This study was conducted with the objective to link the results of diffusion-weighted magnetic resonance imaging (MRI) with the tumor’s histopathological grade. The current study aims to evaluate this and determine the accuracy of diffusion-weighted MRI to determine grade of glioma.
Methods: The present study was a hospital-based cross-sectional purposive study. A total of 50 patients undergoing the MR evaluation of the brain with evidence of clinically suspected cerebral mass were enrolled in study based on inclusion and exclusion criteria. Statistical analysis was performed.
Results: In our study, the minimum apparent diffusion coefficient (ADC) was significantly lower for high-grade than for low-grade gliomas (1119.68±138.33 vs. 717.18±154.38, p<0.001).
Conclusions: By examining diffusion-weighted images and comparing the ADC of gliomas with the World Health Organization grade, we analyze the potential of ADC in predicting tumor grade through this study.