bluuebunny/crossref_metadata_2025 huggingface dataset:
Stone Weights from Gorgippia
Authors: NOVICHIKHIN A.M.
Published: March 2022

Two stone weights, which are large rounded stones (pebbles) with signs applied to them, found in archaeological excavation of Gorgippia Weights belong to the Hellenistic time. The first weight with the inscription ΤΡΕΙΣ (three) weighing 1 518 g corresponds to three mines of the Persian weight system. The second weigh weighing 5 730 g has a sign Μ (40), indicating the weight of fortythirds of the mines of the Euboean-Attic weight system. The monogram ΠΑ on the opposite side of the stone may evidence, that the weight indicated on it was approved by the corresponding magistracy in Panticapaeum.
Tuberculosis in Children: Circulating Mirna a New Diagnostic Method Approach
Authors: L Zeffira
Published: March 2022

Tuberculosis in children is still a challenge for world health problems, especially in establishing a diagnosis. Under diagnosis or over diagnosis can occur in some cases, so getting accurate data is still a challenging task. Clinical symptoms that are not typical in children add to the difficulty of diagnosis enforcement, especially in areas with a high incidence of TB infection. There has been much development of diagnostic TB methods in children, including genetic approach. Some studies report that miRNAs play an essential role in tuberculosis pathogenesis. MicroRNA as one of the diagnostic genetic methods can distinguish the incidence of latent and active infection in tuberculosis cases in children.
Networks in Learning Analytics: Where Theory, Methodology, and Practice Intersect
Authors: Chen Bodong , Poquet Oleksandra
Published: March 2022

Network analysis has contributed to the emergence of learning analytics. In this editorial, we briefly introduce network science as a field and situate it within learning analytics. Drawing on the Learning Analytics Cycle, we highlight that effective application of network science methods in learning analytics involves critical considerations of learning processes, data, methods and metrics, and interventions, as well as ethics and value systems surrounding these areas. Careful work must meaningfully situate network methods and interventions within the theoretical assumptions explaining learning, as well as within pedagogical and technological factors shaping learning processes. The five empirical papers in the special section demonstrate diverse applications of network analysis, and the invited commentaries from cognitive network science and physics education research further discuss potential synergies between learning analytics and other sister fields with a shared interest in leveraging network science. We conclude by discussing opportunities to strengthen the rigour of network-based learning analytics projects, expand current work into nascent areas, and achieve more impact by holistically addressing the full cycle of learning analytics.
Electrophoretic Mobility of Cell Nuclei (EMN) index – relation to biological and physical properties of the cell
Authors: Czapla Zbigniew , Cieślik Joachim
Published: March 2022

The authors describe certain physical and biological properties of cell and resulting electrical and electrokinetic properties, directly or indirectly related with the Electrophoretic Mobility of Cell Nuclei (EMN) index. This index, may become a new criterion in the estimation of the biological age, irrespective of the stage of the ontogenesis.
Fundamentos de la regulación del crowdfunding: a propósito del Decreto de Urgencia 013-2020 que establece el Régimen Jurídico del Financiamiento Participativo Financiero
Authors: Jiménez Alemán José Alonzo
Published: March 2022

El mercado de financiamiento es uno de los ejes de la promoción del emprendimiento, innovación y la creación de empleo. En ese orden de ideas, el financiamiento participativo (o también denominado crowdfunding) se posiciona como una herramienta de crédito importante que, entre otras características, a través de la innovación tecnológica, crea un ecosistema flexible de intermediación directa que permite conectar de forma masiva a inversores y promotores. A su vez, asegura una competencia efectiva de fuentes de financiamiento en el mercado de créditos.En el presente artículo, el autor expone un marco general sobre el crowdfunding y analiza críticamente su regulación en el régimen jurídico peruano. En esa misma línea, tomando en consideración la experiencia comparada, propone algunas recomendaciones normativas, a fin de potenciar el crecimiento de la figura y garantizar su adecuado funcionamiento en el mercado.
Seasonal Influence on Productive and Growth Performance in Awassi Sheep
Authors: Al-Dahl D. Emad D.M. , Shihab Safwan L. , Hadi Haytham M.S.
Published: March 2022

Background: Sheep are one of the important sources of agricultural production in the country and they are one of the pillars of agricultural income. Awassi sheep constitute the numerical majority of Iraqi sheep, as it represents 55-60%. A modern method must be used to in feed, management, improvement of environmental and genetic improvement to increase that productivity in a way that matches the importance of these animals in the livestock sector to achieve the desired target. The season of birth is one of the environmental factors affecting the weight and growth rate of the lambs. Methods: The study was conducted using forty Awassi ewes, 3-4 years old. lambed single male lambs distributed over the two birth seasons (20 ewes/season). The first season was at winter (October to December) and the second season was at spring (February to May). Milk samples were collected 50 ml/ewe for analysis of its components such as fat, protein and solids non-fat percentage, by the German Eco-Milk analyses device. Result: The results of the statistical analysis showed no significant effect for birth season on weight of lambs at birth and a months after birth for the two seasons, while the differences were significant (p≤0.05) at the age of 2 and 3 months in favor of the winter birth. Milk production showed a significant increase (p≤0.05) at the second and third months of ewes in spring season compared to winter. the results showed a significant (p≤0.05) superiority for the percentage of fat, non-fat solids and protein for winter season ewes. A significant positive correlation (p≤0.05) was observed for winter season ewes in body weight, milk fat and protein ratio, a significant positive correlation (p≤0.05) for spring season ewes between body weight and milk production. While the results showed a significant negative correlation (p≤0.05) between the percentage of milk fat for ewes between winter and spring seasons and a highly significant positive relationship (p≤0.05) for milk protein, non-fat solids and weight of ewes for winter and spring seasons, respectively.
Effect of Planting Season on the Residue of Organophosphate in Chili (Capsicum annuum L.)
Authors: . Megawati , Sulaiman Muhammad Ikhsan , Zakaria Sabaruddin
Published: March 2022

Background: Pesticide residues harm human health and are associated with hemopoietic disorders and many organ cancers. This study analyzes the pesticide residue content in chili cultivated by farmers in rainy and dry seasons, especially for organophosphates pesticides. The residual difference in chili was affected by planting seasons caused by farmers’ adoption of crop cultivation technologies, including pesticide application. Methods: The analysis was carried out using gas chromatography on 26 samples from 13 chili cultivation locations in Aceh province, Indonesia. Sixteen samples were harvested during the rainy season and the remaining ten were harvested during the dry season. Result: The results showed that pesticide residues were found in two red chili samples planted in the rainy season, while no residue was found from the dry season. In the rainy season’s harvested samples, the Organophosphate pesticide residues were chlorpyrifos 0.52 mg kg-1 and 0.16 mg kg-1 at Mutiara Tiga sub-district and Meurebo sub-district, respectively. From Meurebo sub-district profenofos 0.74 mg kg-1 was found. All detected pesticide residues samples are still below the maximum residue limit (MRL) set by the Government of Indonesia and CODEX Alimentarius.
An Application of Geographically Weighted Regression for Assessing Water Polution in Pontianak, Indonesia
Authors: Debataraja Naomi Nessyana , Kusnandar Dadan , Nusantara Rossie Wiedya
Published: March 2022

Geographically weighted regression (GWR) is an exploratory analytical tool that creates a set of location-specific parameter estimates. The estimates can be analysed and represented on a map to provide information on spatial relationships between the dependent and the independent variables. A problem that is faced by the GWR users is how best to map these parameter estimates. This paper introduces a simple mapping technique that plots local t-values of the parameters on one map. This study employed GWR to evaluate chemical parameters of water in Pontianak City. The chemical oxygen demand (COD) was used as the dependent variable as an indicator of water polution. Factors used for assessing water pollution were pH (X1), iron (X2), fluoride (X3), water hardness (X4), nitrate (X5), nitrite (X6), detergents (X7) and dissolved oxygen, DO, (X8). Samples were taken from 42 locations. Chemical properties were measured in the laboratory. The parameters of the GWR model from each site were estimated and transformed using Geographic Information Systems (GIS). The results of the analysis show that X1, X2, X3, X5, and X7 influence the amount of COD in water. The resulting map can assist the exploration and interpretation of data.
Richards Curve Implementation For Prediction of Covid-19 Spread in Maluku Province
Authors: Ondi Nanang , Rumlawang Francis Yunito , Lesnussa Yopi Andry
Published: March 2022

COVID-19 (Coronavirus Disease 2019) was first reported in Wuhan city, China at the end of December 2019 and spread to Indonesia specifically in Maluku Province at the end of March 2020. This study aims to predict the spread of COVID-19 cases in Maluku province as well as explore the phases of its spread using the Richards Curve which is an extension of the Logistic Curve. After estimating the parameters of the Richards Function with cumulative case data of COVID-19 in Maluku province from March 23 to November 4, 2020, the results of the spread of COVID-19 cases in Maluku province reached a turning point on October 22, 2020, and ended on May 25, 2023, with a total cumulative case of 9,451 cases
Average Based-FTS Markov Chain Based on a Modified Frequency Density Partitioning to Predict COVID-19 in Central Java
Authors: Hariyanto Susilo , Zaenurrohman Zaenurrohman , SRRM Titi Udjiani
Published: March 2022

COVID-19 is still a pandemic in Indonesia, and Central Java is no exception. New positive cases of COVID-19 in Central Java are being discovered every day. Therefore, researchers try to predict new positive cases in Central Java. Many forecasting methods are currently developing, one of which is fuzzy time series (FTS). FTS has been also developed until now, one of which is a development of the FTS by combining the Markov chain as a defuzzification process. In FTS there is no definite formula to determine the length of the interval, so the researcher uses an average based to determine the length of the interval in the FTS Markov chain. Next, the researcher repartitioned based on the modified frequency density. The results of this study are that forecasting new positive cases of COVID-19 in Central Java using the average based-FTS Markov chain based on a modified frequency density partitioning method has a good level of accuracy, this can be seen from the MAPE value of the method.
Goodwin Model with Clustering Workers' Skills in Indonesian Economic Cycle
Authors: Mahmud Sri Lestari , Resmawan Resmawan , Ismail Sumarno , Nurwan Nurwan , Taki Febriani
Published: March 2022

The economic model which deals with the economic cycle is Goodwin's Model. It presents the relationship between the employment rate and wage shares. In this study, the modification model was made, taking into three types of workers, namely high, medium, and low-skilled workers. Studies of the model are conducted by determining the equilibrium point and its stability analysis. Furthermore, a numerical simulation is given to see which model satisfies the ideal of Goodwin‘s model cycle prediction by using Indonesian data from 2000 to 2020. In the end, an investigation into the effects of reducing the wage gap between the three types of workers was conducted. The results showed two equilibrium points, namely The Equilibrium Point without Employment Rate and The Wages Share (T1) and the Existence Equilibrium Point of Employment Rate and Wages Share (T2). T1 achieves a stable node condition when ScQd+pi+et while T2 reaches a stable center condition when ScQd+pi+et. The simulation showed Goodwin's model of high- and low-skilled workers produced the ideal of Goodwin model cycle predictions, whereas Goodwin's model of medium-skilled workers and the entire economy (capitalist) didn’t produce the ideal of Goodwin model cycle predictions. Eventually, the effects of reducing the wage gap make the economy unstable.
Forecasting Rice Paddy Production in Aceh Using ARIMA and Exponential Smoothing Models
Authors: Nurviana Nurviana , Amelia Amelia , Riezky Purnama Sari Riezky Purnama Sari , Ulya Nabilla Ulya Nabilla , Talib Taufan
Published: March 2022

Indonesia targets Aceh to be one of the paddy production centers and be able to carry out self-sufficient production in paddy and become a national granary. However, in reality, Aceh's paddy production in its province is not consistent from year to year. This province has not been able to meet the food needs of paddy independently, so that it supplies paddy from other regions due to the difficulty of detecting the presence of a surplus of paddy. The purpose of this research is to estimate the results of paddy production in Aceh for the future. The mathematical model that can be used is a time series model namely Autoregressive Integrated Moving Average (ARIMA) and Exponential Smoothing. The results of the estimation of  paddy production in the next 5 years using the ARIMA (1,1,3) model are 2000616; 2017549; 1903585; 1944499; and 1929810. While the estimation results using the Winter Exponential Smoothing model are 1625925; 1645196; 1687667; 1605530; and 1555213. ARIMA model (1,1,3) produces an MSE/MAD value of , while the Winter Exponential Smoothing model produces an MSE/MAD value of . Therefore, it can be concluded that the Winter Exponential Smoothing model.
Quadripolar leads are associated with better results according to bipolar leads in cardiac resynchronization therapy in one-year follow-up: Multicenter, retrospective study
Authors: GUNDUZ Ramazan , USALP Songul
Published: March 2022

Aim: In this study, we compared patients who were performed cardiac resynchronization therapy with quadripolar left ventricle lead or bipolar left ventricle lead in one-year follow-up. We investigated the relationship between the improvements of New York Heart Association classification, electrocardiography and echocardiography parameters according to lead type at one-year follow-up after CRT treatment.
Materials and Methods: In this study, 91 patients were enrolled respectively as bipolar left ventricle lead and quadripolar left ventricle lead. 40 patients are quadripolar left ventricle lead and 51 patients are bipolar left ventricle lead.
Results: After cardiac resynchronization therapy treatment in one year follow-up, patients with ≥1 NYHA improvement was 80% vs 56.8%, p=0.006 and left ventricular ejection fraction ≥5% was 77.5% vs 54.9%, p=0.031 and QRS duration 140.4±11.7 vs 151.7±19.4 ms, p=0.018 in quadripolar and bipolar left ventricle lead respectively. The univariable regression analysis revealed that left ventricular ejection fraction (OR:1.082 95%CI [1.005–1.165], p=0.037), QRS duration (OR:0.980 95%CI [0.961–0.999], p=0.038), NYHA class (OR:1.107 95%CI [0.075–0.682], p=0.008) and left ventricular ejection fraction improvement (OR:2.959 95%CI [1.083–8.086], p=0.034) were better response cardiac resynchronization therapy with quadripolar left ventricle rather than bipolar left ventricle lead. Conclusion: Qdp LVL can be considered instead of BiP LVL to shorten QRS duration and better improve LVEF and NYHA in patients undergoing CRT in long-term follow-up
Nadir görülen plevral kitle: Plevral lipom
Authors: ÇELİK Pınar , HAVLUCU Yavuz , KIZILIRMAK Deniz , SAVAŞ Recep , SAK Işıl
Published: March 2022

Plevral lipomlar, parietal plevranın submezotelyal tabakasından köken alan, benign, yavaş büyüme gösteren ve genellikle soliter yumuşak doku tümörleridir. Sıklıkla asemptomatik olup radyografide insidental olarak saptanırlar. Akciğer grafisinde yumuşak doku dansitesinde görülürler. Burada akciğer grafisinde insidental saptanan plevral lipom olgusu tanısal radyolojik özellikleriyle sunulmakta, ayırıcı tanıda düşünülmesi gereken hastalıklar tartışılmaktadır. Tanı genellikle radyolojik olarak konmaktadır. Şüpheli olgularda transtorasik ya da cerrahi biyopsi uygulanabilir.
CURRENT STATE OF RESEARCH IN THE FIELD OF CHEMICAL COMPOSITION AND PHARMACOLOGICAL EFFECTS OF ZEA MAYDIS STYLI CUM STIGMATIS
Authors: Nikiforova E. B. , Bat N. M. , Davitavyan N. A.
Published: March 2022

Zea maydis styli cum stigmatis (Engl. corn silk) are well known in medical practice. In the scientific literature, a lot of information has been accumulated about the chemical composition and pharmacotherapeutic actions of this medicinal plant material. A chronological analysis of this information shows that earlier, the scope of scientific publications was mainly devoted to the study of the choleretic, diuretic, hemostatic kinds of Zea maydis styli cum stigmatis activity, and the identification of the active substances responsible for these types of action. Currently, there is a growing scientific interest not only in the individual natural compounds of the Zea maydis styli cum stigmatis composition, but also in the search for new aspects of their medical application.

The aim of the article is a review and systematization of modern scientific data in the field of the Zea maydis styli cum stigmatis chemical composition and their pharmacological action.

Materials and methods. For the information and analytical search, the scientific data posted on the following electronic resources were used: PubMed, Web of Science, ScienceDirect, Scopus, Google Scholar, eLibrary. The search was carried out in the period from 2005 to 2021 using the following keywords: Zea mays L.; Zea maydis styli cum stigmatis; corn silk; chemical composition; pharmacological action.

Results. The review is devoted to the generalization and analysis of modern scientific data on the Zea maydis styli cum stigmatis chemical composition and their pharmacological action. It has been shown that, as before, the greatest attention of scientists is attracted by flavonoids in the Zea maydis styli cum stigmatis chemical composition. Alongside with them, phenolcarboxylic acids, vitamin K, phytosterols, volatile compounds and polysaccharides are of no small importance for the Zea maydis styli cum stigmatis pharmacological activity. Modern ideas about the Zea maydis styli cum stigmatis pharmacological activity have been expanded by summarizing the study results of their antioxidant, anti-inflammatory, antidiabetic, hypotensive, neuro- and photoprotective activities. The data on the effectiveness of their use as parts of the complex tumor diseases therapy have been published.

Conclusion. As a result of the data analysis of modern scientific literature, it has been found out that Zea maydis styli cum stigmatis are still in the sphere of scientists’ interest. Alongside with the flavonoids of this raw material, other groups of pharmacologically active substances are also being actively studied. It has been revealed that the information about potentially significant and confirmed types of the Zea maydis styli cum stigmatis therapeutic action is significantly updated. The results of this review may be useful for identifying promising directions for the development of the drugs based on Zea maydis styli cum stigmatis.
DEVELOPMENT OF NITROFURAN DERIVATIVE: COMPOSITION AND TECHNOLOGY OF EFFERVESCENT TABLETS WITH SOLID DISPERSIONS
Authors: Elagina A. O. , Belyatskaya A. V. , Krasnyuk (Jr.) I. I. , Krasnyuk I. I. , Stepanova O. I. , Fateeva T. V. , Smolyarchuk E. A. , Kozin S. V. , Plakhotnaya O. N. , Rаstopchina O. V. , Rau J. V.
Published: March 2022

Taking into account the current Product specification file, the aim of the work was to develop the composition and technology for obtaining effervescent tablets based on solid dispersions of furazolidone in the form of an aqueous solution for external use.

Materials and methods. The used substances were: furazolidone, anhydrous sodium carbonate (chemically pure), polyvinylpyrrolidone-24000±2000 (chemically pure), malic acid (analytically pure), tartaric acid (chemically pure), citric acid (chemically pure), sodium benzoate (chemically pure), ethyl alcohol 96% (chemically pure), purified water. Preparation of granulates is separate wet granulation in a fluidized bed (Mycrolab, BOSCH, Germany). Obtaining tablets is the process of pressing on a manual hydraulic test press (“PRG”, VNIR, Russia). The dependence of disintegration, abrasion capacity and crushing resistance on compacting pressure was investigated. Technological parameters of granulates, еру obtained effervescent tablets, shelf life and storage conditions were investigated according to the State Pharmacopoeia of the Russian Federation XIVth ed.

Results. Two compositions of effervescent tablets containing solid dispersions of furazolidone as an active substance were obtained, which, when dissolved in 100 ml of water at room temperature (20°C), form a solution of furazolidone with a concentration of 0.004% in less than 5 minutes. The method of quantitative determination of the furazolidone content in the effervescent tablets was validated. A complex of physicochemical methods for the analysis of tablets was carried out. Quality standards have been developed. The developed compositions stability of instant tablets during storage during accelerated and long-term tests has been experimentally confirmed. The preliminary shelf life and storage conditions have been determined.

Conclusion. The result of technological and chemical-pharmaceutical research is the creation and evaluation of the quality of a new instant furazolidone dosage form as effervescent tablet formulations.
Estrategias de gestión de mantenimiento para mejorar los indicadores de mantenimiento de equipos de transporte de carga terrestre
Authors:   ,   Universidad San Ignacio de Loyola, Medina Lozano Rocío Del Pilar
Published: March 2022

La presente investigación planteo medir la mejora de los indicadores de mantenimiento de los equipos de transporte de carga terrestre en una empresa de transportes mediante la implementación de estrategias de gestión de mantenimiento, para lo cual responde a características de tipo positivista de enfoque cuantitativo relacional, Asimismo, la presente investigación posee un diseño cuasi experimental ex post facto. la muestra queda definida por muestra pretest y post-test, seleccionadas bajo el criterio de aquellos equipos que presentaron menor operatividad, mayor tiempo de reparación, alto costo de mantenimiento y mayor frecuencia de mantenimiento. Teniendo como muestra 30 equipos, que cumplieron con los criterios antes expuestos. De lo anterior, Se incremento la disponibilidad operativa de los equipos de transporte de carga terrestre de una empresa de transportes mediante la implementación de estrategias de gestión de mantenimiento en un 9%, se redujo el tiempo de reparación de los equipos de transporte de carga terrestre de una empresa de transportes mediante la implementación de estrategias de gestión de mantenimiento, a la mitad, se redujeron los costos de mantenimiento de los equipos de transporte de carga terrestre de una empresa de transportes mediante la implementación de estrategias de gestión de mantenimiento, en un 20%, y se redujo la frecuencia de mantenimiento de los equipos de transporte de carga terrestre de una empresa de transportes mediante la implementación de estrategias de gestión de mantenimiento, a la meta proyectada de 50.
Demanda civil sub especialidad comercial de liquidación de empresa y otros. Expediente N° 06111-2011-0-1817-JR-CO-05 / Demanda laboral de reposición por despido incausado. Expediente N° 06713-2013-0-1801-JR-LA-11
Authors:   ,   Universidad San Ignacio de Loyola, Torres Luján Angela Cecilia
Published: March 2022

En el primer Trabajo de Suficiencia Profesional está orientado en desarrollar las materias jurídicas más relevantes del Expediente N° 06111-2011-0-1817-JR-CO-05, el cual trata sobre liquidación de empresa y otros, cuya demanda fue iniciada por SPECCHI S.A.C. (en adelante, “SPECCHI”), debidamente representada por su Gerente General Oscar Ángel Sampietro Ontoria contra Ana Cecilia Ricci Corvetto para que se dictamine la disolución de pleno derecho de SPECCHI, por la supuesta falta de pluralidad de socios y su no recomposición en el plazo de 6 meses y por ende, se inicie el proceso de liquidación y se disponga la inscripción registral de la extinción en la partida correspondiente. El expediente N° 06713-2013-0-1801-JR-LA-11 que es objeto de análisis en el presente Trabajo de Suficiencia Profesional consiste en uno sobre la materia de reposición por despido incausado, cuya demanda fue presentada por Jesús Michael Pajuelo Echevarría contra la empresa Tecnológica de Alimentos S.A. (en adelante, “TASA”) ante el Juez Especializado de Trabajo Permanente de la Corte Superior de Lima y el trámite de este proceso estuvo sujeto a la vía del proceso ordinario laboral, conforme lo establecido en la Nueva Ley Procesal de Trabajo.
Environmental laws and politics, the relevance of implementing regulation of the presence of emerging pollutants in Mexico: a systematic review
Authors: Sánchez-Ocampo Esmeralda Michelle , Téllez-López Ana María , Islas-Flores Hariz , Gómez-Oliván Leobardo Manuel
Published: March 2022

Aim: To carry out a systematic review of the environmental regulation applicable to emerging pollutants at the international level, with a special interest in Mexico. Methods: The search for articles and documents was carried out under the criteria of the PRISMA statement (Preferred Reporting Items for Systematic Reviews and Meta-Analysis), in databases such as Pub-Med, Scopus, Science Direct, Jane’s, Dimensions, Google Scholar, as well as the Comprehensive System of Standards and Evaluation of the Ministry of the Interior of Mexico. Results: 3089 documents were reviewed, and considering the inclusion, exclusion, and quality criteria, 2 tables were constructed, the first with 24 scientific articles and the second with 7 Mexican standards. Conclusion: The regulation of emerging pollutants is a critical issue that must involve all sectors (for example, political, economic, social, and environmental). For this, it is necessary to coordinate the government, society and consider the experiences of other countries for its implementation. It was also identified that the issues of access to information and education programs have a significant impact on compliance with environmental regulations and that there is little scientific evidence on this matter.
Önce biz! Covid-19 sürecinde aşı milliyetçiliği
Authors: CANSEVER İbrahim Hüseyin
Published: March 2022

Covid-19 pandemisi, etkisini her alanda önemli şekilde hissettirmiş ve dünyayı durma noktasına getirmiştir. Dünyanın normal düzenine dönmesi, süreç başlangıcından itibaren aşı ile mümkün görülmüş ve aşı çalışmaları yaklaşık bir yıllık sürede hızlı şekilde sonuç vermiştir. Ancak aşılara olan yaklaşım kamu malı olmak yerine piyasa malı şeklinde gerçekleşmiş ve aşı milliyetçiliği alevlenmiştir. Çalışmanın amacı, aşı milliyetçiliği olarak bilinen kavramı açıklamak, Covid-19 pandemisi sırasında nasıl ortaya çıktığını ve hangi sonuçları doğurduğunu ortaya koymaktır. Ayrıca, aşı milliyetçiliğine karşı Covid-19 aşılarının adil ve eşit erişimi garanti altına almaya çalışan COVAX girişimi hakkında bilgiler sunulmaktadır. Amaca yönelik olarak ilgili kavram hakkında yapılan çalışmalar doküman incelemesi yöntemiyle incelenmiştir. Aşı milliyetçiliğinin doğurduğu sonuçların ortaya konulması için çeşitli ülkelere ait nicel veriler ve grafikler sunulmuştur. Çalışmanın sonucunda; üst gelir grubu ülkeler ile düşük gelir grubunda yer alan ülkeler arasında aşılama oranlarında önemli derecede fark olduğu, buna karşın vaka ve ölüm sayılarının önemli seviyede devam ettiği görülmüştür. COVAX girişiminin aşı milliyetçiliğine karşı önemli bir girişim olduğu ve aşıları özellikle az gelişmiş ülkeler ulaştırma adına çalışmalar yürüttüğü görülmüştür. Bunun yanında küresel işbirliğinin Covid-19 sürecinde gerçekleşmediği, pandemi öncesinde ortaya konulan Sürdürülebilir Kalkınma Hedeflerinin (SKH) de kâğıt üzerinde iyi niyet göstergeleri olarak kaldığı görülmüştür. Son olarak, küresel işbirliğini, aşının tahsisini ve üretimini destekleyecek uluslararası bağlayıcılığı olan hukuk kurallarının da eksikliği olduğu görülmüştür. .
Spectrofluorometric analysis to trace the molecular fingerprint of wine during the winemaking process and recognise the blending percentage of different varietal wines
Authors: Ranaweera Ranaweera K.R. , Gilmore Adam M. , Bastian Susan E.P. , Capone Dimitra L. , Jeffery David W.
Published: March 2022

As a robust analytical method, spectrofluorometric analysis with machine learning modelling has recently been used to authenticate wine from different regions, vintages and varieties. This preliminary study investigated whether the molecular fingerprint obtained with this approach is maintained throughout the winemaking process, along with assessing different percentages of wine in a blend. Monovarietal wine samples were collected at different stages of the winemaking process and analysed with the absorbance-transmission and fluorescence excitation-emission matrix (A-TEEM) technique. Wines were clustered tightly according to origin for the different winemaking stages, with some clear separation of different regions and varieties based on principal component analysis. In addition, wines were classified with 100 % accuracy according to varietal origin using extreme gradient boosting (XGB) discriminant analysis. The sensitivity of the A-TEEM technique was such that it allowed for accurate modelling of wine blends containing as little as 1 % of Cabernet-Sauvignon or Grenache in Shiraz wine when employing XGB regression, which performed better than partial least squares regression. The overall results indicated the potential for applying A-TEEM and machine learning modelling to wine chemical traceability through production to guarantee the provenance of wine or identify the composition of a blend.
Chronic Exposure to Methadone Induces Activated Microglia and Astrocyte and Cell Death in the Cerebellum of Adult Male Rats
Authors: Zamani Nghmeh , Takbiri Osgoei Laya , Aghaei Abbas , Hassanian Moghaddam Hossein , Zamani Nasim
Published: March 2022

Background: Methadone is a centrally-acting synthetic opioid analgesic widely used in the methadone maintenance therapy (MMT) programs throughout the world. Considering its neurotoxic effects particularly on the cerebellum, this study aims to address the behavioral and histological alterations in the cerebellar cortex associated with methadone administration. Materials and Methods: Twenty-four adult male albino rats were randomized into two groups of control and methadone treatment. Methadone was subcutaneously administered (2.5–10 mg/kg) once a day for two consecutive weeks. The functional and structural changes in the cerebellum were compared to the control group. Results: Our data revealed that treating rats with methadone not only induced cerebellar atrophy, but also prompted the actuation of microgliosis, astrogliosis, and apoptotic biomarkers. We further demonstrated that treating rats with methadone increased complexity of astrocyte processes and decreased complexity of microglia processes. Our result showed that methadone impaired motor coordination and locomotor performance and neuromuscular activity. Additionally, relative gene expression of TNF-α, caspase-3 and RIPK3 increased significantly due to methadone. Conclusions: Our findings suggest that methadone administration has a neurodegenerative effect on the cerebellar cortex via dysregulation of microgliosis, astrogliosis, apoptosis, and neuro-inflammation.
Tools and Data Towards Supporting Quantitative Systems Pharmacology of the Eye – An Overview
Authors: Kuepfer Lars , Fuellen Georg , Stahnke Thomas
Published: March 2022

Good eyesight belongs to the most-valued attributes of health, and diseases of the eye are a significant health care burden. Case numbers are expected to further increase in the next decades due to an aging society. The development of drugs in ophthalmology, however, is difficult due to limited accessibility of the eye, in terms of drug administration and in terms of sampling of tissues for drug pharmacokinetics (PK) and pharmacodynamics (PD). Ocular quantitative systems pharmacology (QSP) models provide the opportunity to describe the distribution of drugs in the eye as well as the resulting drug-response in specific segments of the eye. In particular, ocular physiologically-based pharmacokinetic (PBPK) models are necessary to describe drug concentration levels in different regions of the eye. Further, ocular effect models employing molecular data from specific cellular systems are needed to develop dose-response correlations. We here describe the current status of PK/PBPK as well as PD models for the eye and describe cellular systems, data repositories as well as animal models in ophthalmology. The application of the various concepts is highlighted for the development of new treatments for post-operative fibrosis after glaucoma surgery.
The Singularity of Legendre Functions of the First Kind as a Consequence of the Symmetry of Legendre’s Equation
Authors: van der Toorn Ramses
Published: March 2022

Legendre’s equation is key in various branches of physics. Its general solution is a linear function space, spanned by the Legendre functions of first and second kind. In physics however, commonly the only acceptable members of this set are the Legendre polynomials. Quantization of the eigenvalues of Legendre’s operator is a consequence of this. We present and explain a stand-alone, in-depth argument for rejecting all solutions of Legendre’s equation, but the polynomial ones, in physics. We show that the combination of the linearity, the mirror symmetry and the signature of the regular singular points of Legendre’s equation is quintessential to the argument. We demonstrate that the evenness or oddness of the Legendre polynomials is a consequence of the same ingredients.
KOMUNIKASI PEMASARAN MERUPAKAN LIVE BRIDGING PADA ERA PANDEMI 2020-2021
Authors: Kinkin Yuliaty Subarsa Putri  , Rayni Delya Hafni  , Risma Hasna Dwiwina  , Yesi Andriani  , Kiki Dwi Arviani
Published: March 2022

Abstract

The Covid-19 pandemic in Indonesia disrupted people's livelihoods, both in terms of economic conditions and activities, so that the community's financial sector came to a halt. However, at the end of 2020, economic conditions flared up again. The formulation of the problem in this study is how marketing communication is live bridging in the 2020-2021 pandemic era. The purpose of this study is to determine marketing communication which is live bridging in the 2020-2021 pandemic era. In this study, researchers used quantitative research methods by distributing questionnaires with correlation analysis. This research's results are descriptive; namely, the correlation is positive in marketing communication and community attitudes. In simple regression analysis, there is a strong influence between marketing communication on people's attitudes. Marketing communication theory strongly influences all dimensions of public attitudes, both cognitively, affective, and conative—further research by being developed in collaboration with other scientific studies and using different methods.

Keywords: marketing communication, elaborative research, forecasting research

Abstrak

Pandemi Covid-19 di Indonesia membuat kehidupan bermasyarakat menjadi terganggu, baik dari segi kondisi ekonomi dan aktivitasnya sehingga membuat sektor perekonomian masyarakat menjadi terhenti. Namun, pada akhir tahun 2020 kondisi perekonomian bergejolak kembali. Adapun rumusan masalah dalam penelitian ini adalah bagaimana komunikasi pemasaran merupakan live bridging pada era pandemic 2020-2021 sehingga tujuan penelitian ini untuk mengetahui komunikasi pemasaran yang  merupakan live bridging pada era pandemik 2020-2021. Dalam penelitian ini, digunakan metode penelitian kuantitatif, dengan cara menyebarkan kuesioner dengan analisis korelasi. Hasil dari penelitian ini secara deskriptif yaitu korelasinya bernilai positif pada komunikasi pemasaran dan sikap masyarakat, sedangkan pada analisis regresi sederhana terdapat suatu pengaruh yang kuat antara komunikasi pemasaran terhadap sikap masyarakat. Teori komunikasi pemasaran pada semua dimensinya berpengaruh kuat terhadap semua dimensi sikap masyarakat baik secara kognitif, afektif dan konatif sehingga hasil penelitian ini dapat dikembangkan ke arah penelitian selanjutnya dengan dikembangkan dengan berkolaborasi pada kajian ilmu pengetahuan dan menggunakan metode lainnya.

Kata Kunci: komunikasi pemasaran, penelitian elaboratif, penelitian perkiraan
Saruhanlar Köyü’nün 19. Yüzyılda Sosyo-Ekonomik Yapısı
Authors: SAĞLAM Ahmet
Published: March 2022

Osmanlı nüfus ve temettüat defterleri, yerel tarih çalışmaları yanında birçok bilim dalı için zengin malzeme kaynağıdır. 19. Yüzyılda köy ve kentlerin nüfus bilgileri, etnik ve dini yapıları, sosyo-ekonomik hayatlarına dair önemli istatistiki bilgiler bu defterlerde kayıtlıdır.Makalemizde, Kütahya sancağı Simav kazası nüfus ve temettüat defterleri ışığında günümüz Kütahya-Gediz-Saruhanlar Köyü’nün 1840 yılı nüfus defteri ve 1844/45 yılı temettüat defterine göre köy sakinlerinin sosyo-ekonomik hayatlarını ele alacağız. Nüfus ve temettüat defterlerine göre 200 kişilik bir nüfusa sahip olan köyün geçim kaynakları kuru ve sulu tarım, hayvancılık, bahçecilik, arıcılık özellikle de sepetçilik işleridir. Köy sakinleri arasında ırgat olanlar ve muhtaç kimselerin kayıtları vardır. Köy kurulduğu 1600’lerden günümüze Saruhanlar adı ile anılmıştır. Günümüzde köy sakinlerinin önemli bir uğraşı yöreye özgü gürgen ağacından imal ettikleri kaşıkçılıktır. Saruhanlar sakinlerinin geçmişte sepetçilik işini yapmaları bu insanların hünerli, sanatkâr insanlar olduğunu gösterir.
A Comparison of Status of Nutrition Management in Long-Term Care Facilities With and Without Dietitian
Authors: Kwon Jin Hee , Hwang Rah Il , Ryu Jaehyeon
Published: March 2022

Objectives: The study was performed to compare the status of nutrition management with and without dietitian in residential facilities in order to provide basic data for high quality of nutrition management services across the country.Methods: Among long-term care facilities with claims of benefits, 747 samples were extracted through a proportionate stratified sampling method based on region, agents of foundation, types of food service, and facility size.Results: The subjects of the survey were dietitian, general managers, or facility directors. Nutrition evaluation, nutrition intervention, and nutrition monitoring were performed by professional staff at the residential facilities with a dietitian. On the other hand, it was found that the rate of nutrition management performance was relatively low in residential facilities where no dietitian was assigned, and it was performed by non-professional personnel such as nurse aids and social workers.Conclusions: The results of this study suggested that developing strategies is required to reinforce the safe minimal standard of dietitians’ staffing levels for systematic nutrition management.
Development of Breast Cancer Prognosis Prediction Model Based on Clinical Features Including CEA and CA15-3 Serum Levels
Authors: Yang Hee Soo , Kwon Seonguk , Lee Seunghee , Lee Suehyun , Kim Jong-Yeup
Published: March 2022

Objectives: Serum levels of carcinoembryonic antigen and cancer antigen 15-3 tumor markers are used for breast cancer prognosis. This study developed a breast cancer prognosis prediction model.Methods: We retrospectively analyzed data of 639 patients diagnosed between January 2012 and December 2019. We selected 20 independent variables with carcinoembryonic antigen and cancer antigen 15-3 serum levels and employed four machine-learning algorithms for the model: artificial neural network, random forest, support vector machine, and logistic regression.Results: Significant differences in carcinoembryonic antigen and cancer antigen 15-3 serum levels, age, history of other diseases excluding hypertension and diabetes mellitus, chemotherapy, and drug therapy were noted between control (n = 576) and case groups (n = 63). The sensitivity and specificity of the artificial neural network model for prognosis prediction were 26.7% and 92.6%, respectively.Conclusions: Carcinoembryonic antigen and cancer antigen 15-3 serum levels were the most significant variables for developing a breast cancer prognosis prediction model using the Shapley additive explanations model. The proposed machine-learning model and tumor marker serum levels may be useful for breast cancer prognosis.
Association between Principal Diagnosis with Mental Diseases among Inpatients
Authors: Kim Sung-Soo
Published: March 2022

Objectives: The purpose of this study was to determine the prevalence of the principal diagnosis among hospitalized patients with mental disorders and to investigate the association between the principal diagnosis and mental diseases as comorbidity.Methods: The subjects of this study were patients with mental disorders, regardless of the main diagnosis, among the Korean National Hospital Discharge In-depth Injury Survey (KNHDS) from 2006 to 2018. Frequency analysis was performed on the general characteristics, principal diagnosis, and mental disorders of the study subjects. The association between the principal diagnosis and mental diseases was analyzed for patterns using association rule mining (ARM).Results: The main result is that liver diseases are fairly associated with behavioral disorders due to psychoactive substance use. And then organic, including symptomatic, and mental disorders are associated with cerebrovascular diseases, Influenza and pneumonia, and other degenerative diseases of the nervous system. Mood disorders are linked to poisoning by drugs, medicaments, and biological substances.Conclusions: It is necessary to raise awareness of mental diseases and to build a care cooperative system between diseases that are highly associated. It will be possible to monitor key association rules and apply them to clinical decision-making systems.
Effects of Perceived Safety Culture, Nursing Work Environment, and Professional Self-concept on Patient Safety Care Activity of Nurses in Small-medium Sized Hospitals
Authors: Cho Young Ok , Kim Myoung Soo
Published: March 2022

Objectives: The purpose of this study was to investigate the influencing factors of perceived safety culture, nursing work environment, and professional self-concept on patient safety care activities of nurse in small-medium sized hospitals.Methods: A cross-sectional survey was used. Participants were 186 nurses in seven small-medium sized hospitals of a metropolitan city, in Korea. Data were analyzed using multiple linear regression analysis.Results: The influencing factors of the patient safety care activities were perceived patient safety culture and professional self-concept. These two factors explained for 15.1% of the patient safety acre activities.Conclusions: Based on the result of this study, it is necessary to build a good patient safety culture and to develop a positive professional self-concept. The establishment of a positive safety culture should be prioritized to quickly recognized and sensitively accept problems related to patient safety and actively carry out patient safety nursing activity. In order to improve the professional self-concept, it is necessary to increase the social performance for voluntary cooperation and to recognize the self-categorization that the group to which one belongs is distinguished from other groups.
The Factors Influencing Selection for Rehabilitation Hospital After Stroke
Authors: Kim Miok , Kim Keon-Yeop
Published: March 2022

Objectives: The purpose of this study was to investigate the factors influencing selection for rehabilitation hospital in patients who have been diagnosed with stroke.Methods: This study included 169 stroke patients who were admitted to the top 5 hospitals with the highest recovery rate among 13 hospitals where the rehabilitation medicine is operated as the main medical department in Daegu Metropolitan City. The data was collected from 10 February, 2020 to 17 March, 2020, and the survey was conducted by the head of the hospital administration in each hospital for about a month through face to face.Results: Among the factors influencing selection for rehabilitation hospital after stroke, image factors were at the highest mean and standard deviation (3.83 ± 0.74), following human factors (3.75 ± 0.77), physical factors (3.57 ± 0.89), efficiency factors (3.35 ± 0.69), accessibility factors (3.11 ± 1.00). In the demographic characteristics, human factors were considered important when selecting hospital in aged people over 70 years old (p< 0.01). Efficiency factors and human factors were considered important if patients living outside Daegu (p< 0.05), but accessibility factors were more important if patients living in Daegu (p< 0.01). In the stroke related characteristics, the human factors were considered important in the shorter the disease period, and in the case of having swallowing disorders (p< 0.05). When paralysis was affected on both sides (bilateral paralysis), physical factors were considered important (p< 0.05), and efficiency factor was also considered important as the disease periods gets shorter (p< 0.05). Efficiency factors and accessibility were important in the case of not having respiratory disorders compared to those with the respiratory disorders (p< 0.05). The results of the factors for choosing a hospital according to the stroke diseases-related characteristics showed that human factors, physical factors, and hospital image factors were considered important in case of putting much of the efforts to gather hospital information (p< 0.01). When the patients who had rehabilitation in the tertiary hospital prior to the current hospital admission, the physical factors were considered important (p< 0.05).Conclusions: This study found that various factors were considered in patients who have been diagnosed with stroke, when selecting rehabilitation hospital after stroke. Therefore, it should be warranted to provide reliable and objective hospital information for stroke patients through establishing national level health system and sharing rehabilitation data so that the people can get effective rehabilitation at the right time.
Анализ динамики эпидемического процесса COVID-19 в мире за неделю с 05.03.2022 г. по 11.03.2022 г.
Authors: Зимирова Анастасия , Поспелов Михаил , Иванова Александра , Дмитриева Людмила , Чумачкова Елена , Карнаухов Игорь , Щербакова Светлана , Кутырев Владимир
Published: March 2022

В обзоре представлен анализ эпидемиологической ситуации в странах мира по COVID-19, за неделю с 05.03.2022 г. по 11.03.2022 г.