bluuebunny/crossref_metadata_2025 huggingface dataset:
Médeia, a korinthosi feleség
Authors: D. Tóth Judit
Published: October 2021

Among the modern interpretations of Medea, one of the most influential plays by Euripides, which was first performed in 431 BC, there is a so-called “barbarian Medea” reading, which explains the murderous deeds of the heroine (including the killing of her own children) primarily through her barbarian descent and otherness. In this paper, however, I wish to join another trend among the related, rather expansive, research efforts, which identifies the ultimate reason for the revenge taken by this fierce and impetuous protagonist not in her otherness deriving from her barbarity but essentially in her quality as a cheated and humiliated spouse. In my study, I intend to focus on the figure of Medea as a “Corinthian wife” on the basis of three significant locations in the text of the play: the speech of the Nurse (1–45), Medea’s lamentation (214–267), and the agon between Medea and Jason (446–626). It is my intention to contend that during the “peaceful” years spent in Corinth (cf. 11–15), Medea is an average wife, just like any other woman of her age, until Jason decides to leave her. At this point, however, since she takes Jason’s oath sworn to Zeus and the other gods seriously, she abandons the traditional role of “the ideal wife” and exacts her revenge planned on the prompt of her desperation and the specific combination of circumstances. All this relates her back to her mythic past but, in this case, her barbarity becomes an indication of her otherness as a woman, the same way as her deeds become a medium of the experience shared by contemporary spouses and women.
Anna-szignumok Tolsztoj és Kosztolányi prózájában
Authors: Kovács Árpád
Published: October 2021

The study approaches the interpretation of the two novels with the tools of prose poetics. It unfolds the manifestations of the isomorphy of the name and the text at the level of narration, metaphorical meaning and semantic innovations. It explores the coreferential operation that can be perceived between the text interior and the texts, and also the source texts of these entities in the subject of judgment and mercy. From a generic perspective, the interference of the epic novel, the thesis novel, and the sacral discourse gains more attention, along with their polemic character as opposed to the norms of political utterance. With regards to the symbolic systems of both novels, the study thoroughly examines the central role of the interrelations of love, corporeality and spirituality, and also their coreferential connections to the poetics of Charis and Charisma. The poetic relevancies of the two writers’ statements are also explored, so that the fundamentals of their unique literary anthropology can be enlightened.
Szerkesztői előszó
Authors: Bényei Péter
Published: October 2021

Az irodalmi szövegek olvasása, kommentálása és értelmezése évezredes gyökerekhez vezethető vissza, még ha közismert, hogy széles körben elterjedt gyakorlattá, kritikai és tudományos praxissá elsősorban a modernitás korától vált a szöveginterpretáció, amikor is az irodalom levált az írott szövegek összeségéről, önállósodott, s fokozatosan kialakultak és meggyökeresedtek az irodalom tudományos használatához kapcsolódó intézmények. A középiskolai és az egyetemi irodalomtanításban is kiemelt szerephez jut mind a mai napig az értelmező tevékenység: az interpretáció gyakorlata összhangba hozható a befogadás élményszerű aspektusaival, s az irodalmi szövegek minél komplexebb és intenzívebb megszólaltatása rengeteg olyan beszélgetés kezdeményezésére teremthet lehetőséget, amely az ön- és világmegértésnek, a kreativitás fejlesztésének, az érzelmi intelligencia kibontakozásának egyaránt médiuma lehet.
Aproximación a la interpretación conforme como técnica de coordinación normativa
Authors: Arzoz Santisteban Xabier
Published: October 2021

Este trabajo pretende contribuir al estudio de la interpretación conforme como técnica de coordinación entre ordenamientos jurídicos. Aunque la modalidad primigenia y más destacada en el derecho comparado es el principio de interpretación conforme a la Constitución, existen otras modalidades más complejas, como la interpretación conforme a los tratados internacionales sobre derechos humanos y al derecho de la Unión Europea. El artículo, en la primera parte, ofrece una vista panorámica de la consolidación del principio de interpretación conforme al derecho internacional de los derechos humanos en el continente europeo, para dar cuenta de su creciente protagonismo como técnica de coordinación normativa en el derecho comparado. En la segunda parte formula una teoría general de la interpretación conforme, elaborada a partir de los rasgos comunes de los tres subprincipios de interpretación conforme reconocidos en el ordenamiento jurídico español. En la tercera parte se regresa al punto de partida, que es el principio de interpretación conforme a la Constitución. Aunque este principio rige de forma aparentemente indiscutida para todos los operadores jurídicos, se detecta una cierta anemia en su aplicación por la jurisdicción contencioso-administrativa española. Por ello, se indagará en las causas de la asimetría entre el valor dogmático atribuido al principio en el plano discursivo y su uso limitado en la práctica de los jueces ordinarios, que no del juez constitucional.
PENGARUH PENGGUNAAN LKM TRIGONOMETRI BERBASIS PENEMUAN TERBIMBING TERHADAP HASIL BELAJAR
Authors: Julianingsih Denok
Published: October 2021

The purpose of this study was to determine whether there was an effect of using Guided Discovery-based Trigonometry LKM on student learning outcomes in Trigonometry lectures even semester 2019/2020. This research is a quasi-experimental research with 8 students who teach trigonometry as a research subject. The design in this study used a one-group pretest-posttest design. The instrument used in this study was a test of learning outcomes consisting of pretest and posttest. The data analysis technique used was descriptive statistical analysis and inferential statistical analysis. The data were processed using SPSS 22. Based on the results of the descriptive analysis of student learning outcomes after the lecture using the Guided Discovery-based Trigonometry LKM was better than before using the Guided Discovery-based Trigonometry LKM. The average post-test learning outcome was 90.75 while the average learning outcome pretest of 28.75. As seen here there is an average increase of 62.00. While the results of inferential statistical analysis using the Wilcoxon Signed Rank Test obtained the value of Z count > Z table, namely -2.524 > -1.96, which means Ho is rejected and Ha is accepted. Meanwhile, based on the results of comparing the probability values, the Asymp value is obtained. Sig. (2-tailed) < the alpha value of 0.012 < 0.05 which means Ho is rejected and Ha is accepted. This means that there is a difference in the average results of students who use Guided Discovery-based Trigonometry LKM and students who do not use Guided Discovery-based Trigonometry LKM. That is, there is an effect of using Guided Discovery-based Trigonometry LKM on student learning outcomes.
ON THE ISSUE OF FORECLOSURE ON A SINGLE RESIDENTIAL PREMISES UNDER A MORTGAGE AGREEMENT
Authors: Скворцова Татьяна Александровна , Кухмистрова Яна Валерьевна
Published: October 2021

В статье рассматриваются правовые проблемы обращения взыскания на единственное жилое помещение по договору ипотеки. Проанализированы вопросы достижения баланса интересов кредитора и заемщика, а также защиты прав на жилище несовершеннолетних и недееспособных членов семьи заемщика. Сделан вывод о необходимости изменения положений законодательства об исполнительском иммунитете в отношении единственного жилого помещения.

The article deals with the legal problems of foreclosure on a single residential premises under a mortgage agreement. The issues of achieving a balance of interests of the lender and the borrower, as well as the protection of the rights to housing of minors and incapacitated family members of the borrower are analyzed. It is concluded that it is necessary to change the provisions of the legislation on executive immunity in relation to a single residential premises.
Human Activity Recognition Using The Human Skeleton Provided by Kinect
Authors: Salim Heba , Alaziz Musaab , Abdalla Turki
Published: October 2021

In this paper, a new method is proposed for people tracking using the human skeleton provided by the Kinect sensor, Our method is based on skeleton data, which includes the coordinate value of each joint in the human body. For data classification, the Support Vector Machine (SVM) and Random Forest techniques are used. To achieve this goal, 14 classes of movements are defined, using the Kinect Sensor to extract data containing 46 features and then using them to train the classification models. The system was tested on 12 subjects, each of whom performed 14 movements in each experiment. Experiment results show that the best average accuracy is 90.2 % for the SVM model and 99 % for the Random forest model. From the experiments, we concluded that the best distance between the Kinect sensor and the human body is one meter.
A MOROSIDADE JUDICIAL NA JUSTIÇA COMUM: UMA ANÁLISE DA REALIDADE DA COMARCA DE DIANÓPOLIS/TO
Authors: Correia Italo Schelive , Rodrigues Vivian Maria Matheus , Diniz Hamurab Ribeiro
Published: October 2021

A morosidade na prestação jurisdicional é uma realidade que atinge todo o Sistema Judiciário brasileiro, em graus e proporções diferentes. Tal situação afeta de diversas formas os jurisdicionados, que aguardam a resolução de suas lides por um tempo demasiadamente longo, acarretando em uma descrença na efetividade da justiça. Visando melhor conhecer a realidade local, importante se fez esta pesquisa, que objetivou descobrir se a prestação jurisdicional ocorre de forma satisfatória ou se há morosidade na Justiça Comum da Comarca de Dianópolis/TO. Para tanto, foram utilizadas as informações disponibilizadas no site do Tribunal de Justiça do Estado do Tocantins, que contém, na forma de gráficos, os números exatos de processos distribuídos, julgados e baixados. Através desses dados se pode visualizar a produtividade do sistema judiciário e, após a análise, foi possível observar que os números de processos distribuídos, julgados e baixados são muito próximos, o que indica celeridade, demonstrando, assim, que a Justiça Comum na Comarca de Dianópolis/TO não é morosa.
Escasez de conductos biliares: etiología de colestasis neonatal
Authors: Coronado Ana Karina , Araúz María
Published: October 2021

Reportamos el caso de lactante con colestasis que fue diagnosticado como síndrome de Alagille sindrómico. La característica principal de la enfermedad es la escasez de conductos biliares. Es una enfermedad hereditaria, de transmisión autosómica dominante con penetración incompleta, secundaria a mutaciones en los genes JAG1 (más del 90%) y NOTCH21, que inducen una alteración del desarrollo embriológico que afecta a estructuras dependientes del mesodermo1.Describimos el caso y discutimos sus hallazgos clínicos y radiológicos.
Numerical and Experimental Study on Optimization of Coil Springs used in Vehicles’ Suspension System
Authors: Rahman Mostafizur , Abdullah Saeem Bin
Published: October 2021

In general, the suspension systems are used to absorb vibrations, bump, rolls, dip from shock loads due to road surface irregularities. It performs its major role without affecting the vehicles’ stability and overall handling during operation. Coil springs are used as suspension element in light vehicles to attenuate unwanted vibrations. A spring is an elastic object used to store mechanical energy and it can be twisted, pulled or extended by some force and can return to its initial position when the force is released. In this study, mild steel material was taken into consideration in designing and fabricating coil springs. Theoretical and experimental investigations were conducted to calculate springs’ stiffness and to make validation between them. Three model of springs having coils 10, 11, 14 respectively are designed which have slight stiffness difference both theoretically and experimentally. The models were analyzed to determine mechanical behaviors for randomly chosen loading conditions ranging from 29.4 N to 176.4 N which are better suited with spring size.  It is noted from both numerical and experimental investigations that deflection is high when the stiffness is less and vice-versa. In addition, shear stress formation increases with the increment of stiffness and applied load. Hence, springs having high stiffness are used in suspension system to reduce vibration and other disturbances. This study shows springs of having high stiffness are comparatively compact in size and cost economic as well.
Kinh nghiệm qua 126 bệnh nhân phẫu thuật nội soi cắt toàn bộ dạ dày điều trị ung thư dạ dày
Authors: Nguyen Van Huong
Published: October 2021

TÓM TẮT

Đặt vấn đề: Báo cáo kinh nghiệm về kỹ thuật phẫu thuật nội soi cắt toàn bộ dạ dày qua 126 bệnh nhân điều trị ung thư dạ dày tại Bệnh viện Hữu nghị Đa khoa Nghệ An.

Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả hồi cứu, các bệnh nhân được phẫu thuật nội soi cắt toàn bộ dạ từ 2014 đến 05/2021.

Kết quả: Có 126 bệnh nhân, tuổi trung bình 60,6 ± 11,1 tuổi. 15,9% ung thư 1/3 trên dạ dày và 81,7% là 1/3 giữa. Ung thư ở giai đoạn I, II, III là 19,0%, 49,2%, 31,7%. 71,4% PTNS hoàn toàn cắt TBDD và nối lưu thông tiêu hóa bằng máy cắt nối thẳng. 3,2% trường hợp có tai biến trong mổ và 2,4% có biến chứng sau mổ, không có trường hợp nào tử vong. Số hạch nạo vét được trung bình 22,06 ± 7,6 hạch, lượng máu mất trung bình là 32,14 ± 10,4 ml, thời gian phẫu thuật trung bình là 210,4 ± 34,3 phút, thời gian nằm viện trung bình là 8,3 ± 2,5 ngày và thời gian sống thêm toàn bộ sau mổ trung bình là 36,9 ± 2,25 tháng.

Kết luận: PTNS cắt TBDD là kỹ thuật an toàn và hiệu quả trong điều trị UTDD, nối thực quản hỗng tràng bằng máy cắt nối thẳng không cắt thực quản và hỗng tràng trước là kỹ thuật an toàn, tiết kiệm.

Từ khóa: Kỹ thuật phẫu thuật nội soi dạ dày, ung thư dạ dày.

ABSTRACT

EXPERIENCE IN 126 PATIENTS OF LAPAROSCOPIC TOTAL GASTRECTOMY FOR THE TREATMENT OF GASTRIC CANCER

Background: The goal of this study was to report on the experience of laparoscopic total gastrectomy (LTG) in 126 patients with gastric cancer

Materials and Methods: Retrospective descriptive study of 126 patients who underwent LTG for gastric cancer between 2014 and May 2021.

Results: Mean age 60,6 ± 11,1; gastric cancer at stage I, II, III was 19,0%, 49,2%, 31,7% respectively. 71,4% patients underwent totally LTG and functional end-to-end esophagojejunostomy by linear stapler without previous resection of esophagus and jejunum. 3.2% of cases had complications during surgery and 2,4% of cases had complications after surgery. There was no postoperative deaths. The average number of dredged lymph nodes was 22.06 ± 7.6 lymph nodes. The mean blood loss was 32.14 ± 10.4 ml. The mean operative time was 210.4 ± 34.3 minutes. The mean time for beginning oral feeding was 4.4 ± 1.9 days. The mean hospital stay was 8.3 ± 2.5 days. The mean overall survival was 36.9 ± 2,25 months.

Conclusions: LTG is a safe and effective technique for the treatment of gastric cancer. The technique functional end-to-end esophagojejunostomy by linear stapler without previous resection of esophagus and jejunum was safe and saving.

Keywords: Technique of laparoscopic gastrectomy, gastric cancer
Nghiên cứu sự kháng kháng sinh của các chủng vi khuẩn gây nhiễm khuẩn đường tiết niệu phân lập được tại Bệnh viện Hữu nghị Đa khoa Nghệ An
Authors: Quế Anh Trâm
Published: October 2021

TÓM TẮT

Đặt vấn đề: Xác định đúng căn nguyên gây NKĐTN và mức độ kháng kháng sinh của các vi khuẩn sẽ giúp cho việc điều trị có hiệu quả, giảm được chi phí điều trị, hạn chế sự gia tăng vi khuẩn đề kháng kháng sinh.

Đối tượng và phương pháp nghiên cứu: Các chủng VK gây nhiễm khuẩn đương tiết niệu phân lập được tại bệnh viện Hữu nghị Đa khoa Nghệ An từ 1/2020 đến 12/2020. Thiết kế nghiên cứu: Cắt ngang mô tả.

Kết quả: Phân lập được 473 chủng vi khuẩn gây NKĐTN, trong đó, E. coli 38,48%; P. aeruginosa 14,15; Enterococcus sp 10,57; K. pneumoniae 13,32%. E. coli: kháng các kháng sinh Cephalosporine, Quinolones từ 56,7 - 63,8%, Carbapenem 4,5 - 6,2%, sinh ESBL 49,4%. P. aeruginosa: đã kháng các kháng sinh thử nghiệm từ 59,1 - 69,2%. Enterococcus sp: kháng với các kháng sinh nhóm Quinolone 73,5%, kháng Vancomycin 8,3%; Chưa ghi nhận đề kháng Linezolid. K. pneumoniae: kháng nhóm Cephalosporin, Quinolone từ 66,7 - 74,6%, đề kháng với Carbapenem từ 46,0 - 50,8%.

Kết luận: Các vi khuẩn gây nhiễm khuẩn tiết niệu thường gặp là: E. coli, P. aeruginosa, Enterococcus sp. K. pneumoniae. Các vi khuẩn phân lập được đã đề kháng với nhiều kháng sinh thường dùng với các mức độ khác nhau. Xuất hiện các chủng vi khuẩn Gram âm kháng Carbapenem, Gram dương kháng Vancomycin.

Từ khóa: Nhiễm khuẩn tiết niệu, E.coli, Klebsiella, P.aeruginosa, Enterococcus sp

ABSTRACT

RESEARCH OF ANTIBIOTICS RESISTANCE OF BACTERIA STRAINS CAUSING URINARY TRACT INFECTIONS ISOLATED AT NGHEAN FRIENDSHIP GENERAL HOSPITAL

Background: The good identification of UTI microorganism and their antimicrobial susceptibility would promote the effective treatment, reduce the cost as well as the emergence of drug resistant bacteria.

Methods: Bacterial strains causing urinary tract infections were isolated at Nghe An Friendship General Hospital from 1/2020 to 12/2020. Study design: Descriptive cross section.

Results: 473 bacterial strains causing UTIs were isolated, in which, E. coli 38.48%; P. aeruginosa 14.15; Enterococcus sp 10.57; K. pneumoniae 13.32%. E. coli: resistant to Cephalosporin antibiotics, Quinolones from 56.7 - 63.8%, Carbapenem 4.5 - 6.2%, producing ESBL 49.4%. P. aeruginosa: was resistant to the tested antibiotics from 59.1 - 69.2%. Enterococcus sp: resistant to Quinolone antibiotics 73.5%, resistant to Vancomycin 8.3%; Linezolid resistance has not been recorded. K. pneumoniae: resistant to Cephalosporin, Quinolone from 66.7 - 74.6%, resistant to Carbapenem from 46.0 - 50.8%.

Conclusion: Common bacteria causing urinary tract infections are: E. coli, P. aeruginosa, Enterococcus sp. K. pneumoniae. The isolates were resistant to many commonly used antibiotics to varying degrees. Occurrence of strains of Gram - negative bacteria resistant to Carbapenem, Gram - positive resistant to Vancomycin.

Keywords: Urinary Tract infections, E. coli, Klebsiella, P. aeruginosa, Enterococcus sp.
U mỡ trong xương bướm: một trường hợp hiếm gặp
Authors: Trinh Thi Thu Hien
Published: October 2021

TÓM TẮT

U mỡ trong xương là khối u lành tính hiếm gặp, thường gặp ở các xương dẹt, hiếm gặp ở xương nền sọ, đặc biệt là xương bướm. Trong đa số các trường hợp, u mỡ trong xương bướm thường được phát hiện tình cờ qua chụp cắt lớp vi tinh (CLVT) hoặc cộng hưởng từ (CHT) sọ não. Đây là một khối u phát triển chậm, ít gây ra triệu chứng, một số trường hợp gây triệu chứng khi khối u to chèn ép vào cấu trúc lân cận như tuyến yên hoặc dây thần kinh thị. Trong bài này, chúng tôi báo cáo một trường hợp u mỡ trong xương bướm không triệu chứng được phát hiện tình cờ và được chẩn đoán dựa vào phim chụp cộng hưởng từ sọ não. Bệnh nhân được khuyến nghị theo dõi định kỳ bằng cộng hưởng từ mà không phải tiến hành bất kỳ phương pháp điều trị nào.

Từ khóa: U mỡ, xương bướm, MRI, cộng hưởng từ sọ não, chẩn đoán hình ảnh.

ABSTRACT

INTRAOSSEOUS LIPOMA OF SPHENOID BONE: A RARE CASE REVIEW

Intraosseous lipoma is very rare, usually benign tumor of flat bones. The incidence of an intraosseous lipomalocated basal skull bones is extremely rare, especially in sphenoid bone. Radiological imaging techniques such as magnetic resonance imaging (MRI) and computed tomography (CT) are used to detect the intraosseous lipoma by accident. These tumors are slow growing and usually asymptomatic, in some cases causing symptoms when the large tumor presses on nearby structures such as pituitary gland or the optic nerve. We present a rare case of lipomaof the sphenoid bone discovered incidentally with brain magnetic resonance imaging. The patient has been followed-up by magnetic resonance imaging without the need for surgery.

Keywords: Intraosseous lipoma, sphenoid bone, MRI, brain MRI, diagnostic radiology
Kết quả phẫu thuật điều trị bệnh lý gián đoạn quai động mạch chủ tại Bệnh viện Nhi Trung ương
Authors: Nguyen Ly Thinh Truong
Published: October 2021

TÓM TẮT

Mục tiêu: Đánh giá kết quả tạo hình quai động mạch chủ trong phẫu thuật một thì điều trị bệnh lý GĐQĐMC tại Bệnh Viện Nhi Trung Ương từ năm 2012 đến 2019.

Phương pháp: Nghiên cứu hồi cứu 53 bệnh nhân được phẫu thuật sửa chữa một thì bệnh tim bẩm sinh GĐQĐMC từ tháng 01 năm 2012 đến tháng 12 năm 2019.

Kết quả: Bệnh nhân gồm 32 nam và 21 nữ. Tuổi trung bình là 43 ± 53 ngày, cân nặng trung bình khi phẫu thuật 3.4 ± 0.7 kg. Trung bình thời gian chạy máy tim phổi nhân tạo (TPNT) là 128 ± 28 phút, thời gian cặp chủ 92 ± 18 phút và thời gian tưới máu não chọn lọc là 34 ± 11 phút. Tử vong sớm sau mổ có 9 bệnh nhân (16.9%). Thời gian theo dõi trung bình 37 ± 21 [8-95] tháng. Tỷ lệ sống sót chung sau phẫu thuật là 83% tại thời điểm 8 năm. Tỷ lệ sống sót không phải can thiệp lại do tái hẹp quai ĐMC là 97.6% tại thời điểm 8 năm, không có bệnh nhân tử vong trong quá trình theo dõi.

Kết luận: Phẫu thuật một thì sửa chữa bệnh lý GĐQĐMC ở Bệnh viện Nhi Trung ương là hoàn toàn khả thi và có thể thực hiện được ở lứa tuổi sơ sinh và nhũ nhi với tỷ lệ tử vong thấp.

Từ khóa: Gián đoạn quai động mạch chủ, thông liên thất, hẹp đường ra thất trái, cửa sổ chủ phế.

ABSTRACT

OUTCOMEOF SURGICAL REPAIR FOR INTERRUPTED AORTIC ARCH IN NATIONAL CHILDREN’S HOSPITAL, HANOI

Objective: The objective was to determine outcomes of aortic arch reconstruction in one-stage repair of interrupted aortic arch in Nation Hospital of Pediatrics from 2012 to 2019.

Methods: Records of 53 consecutive patients undergoing interrupted aortic arch repair between January 2012 to December 2019 were reviewed. Single-stage repair was performed in all of the patients.

Results: The patients consisted of 32 males and 21 females. Mean age of the patients was 43 ± 53 days and mean weight was 3.4 ± 0.7 kg. The average cardiopulmonary bypass time was 128 ± 28 minutes, the aortic cross-clamp time was 92 ± 18 minutes and the selective cerebral perfusion time was 34 ± 11 minutes. Early mortality was 16.9%. Mean follow-up was 37 ± 21 [8-95] months. Actuarial survival including early death was 83% at 8 years. The freedom from reintervention of recurrent aortic arch obstruction was 97.6% at 8 years. No late death occurred.

Conclusions: Single-stage repair of interrupted aortic arch with intracardiac defects is safe and feasible with newborn and infant in National Hospital of Pediatrics.

Keyword: Interrupted aortic arch, ventricular septal defect, left ventricular outflow tract obstruction, aortopulmonary window
Gánh nặng xơ vữa động mạch cảnh ở người mắc bệnh động mạch vành sớm
Authors: Truong Thanh Huong
Published: October 2021

TÓM TẮT

Đặt vấn đề: Dữ liệu xơ vữa động mạch (ĐM) cảnh ở người mắc bệnh động mạch vành sớm (BĐMVS) còn hạn chế tại Việt Nam. Do đó, nghiên cứu này nhằm mục tiêu xác định tỉ lệ xơ vữa ĐM cảnh và các yếu tố liên quan đến tình trạng này ở người mắc BĐMVS tại Việt Nam.

Đối tượng, phương pháp nghiên cứu: Đây là nghiên cứu mô tả với 94 người mắc BĐMVS được siêu âm ĐM cảnh.

Kết quả: Tình trạng hẹp ĐM cảnh không ý nghĩa và có ý nghĩa quan sát thấy ở 16 (17.0%) và 4 bệnh nhân (4.3%), tương ứng. Phân tích hồi quy logistic đa biến thấy nồng độ lipoprotein cholesterol tỷ trọng thấp (LDL-C) trong máu liên quan độc lập với hẹp ĐM cảnh có ý nghĩa (Odds Ratio = 1.504).

Kết luận: Tại Việt Nam, người mắc BĐMVS có tỉ lệ cao bị hẹp ĐM cảnh. Sàng lọc hẹp ĐM cảnh nên được thực hiện cho nhóm bệnh nhân này, đặc biệt là khi có kèm tăng LDL-máu.

Từ khoá: Xơ vữa, hẹp động mạch cảnh, bệnh động mạch vành, sớm

ABSTRACT

BURDEN OF CAROTID ATHEROSCLEROSIS IN PATIENTS WITH PREMATURE CORONARY ARTERY DISEASE

Background: Data about carotid atherosclerosis in patients with premature coronary artery disease (PCAD) is still limited in Vietnam. Therefore, this study aims to investigate the prevalence of carotid atherosclerosis in patients with PCAD and factors related to carotid stenosis in these patients in Vietnam.

Methods: This is a cross-sectional study that enrolled 94 patients with PCAD. All of patients were screened carotid atherosclerosis using ultrasonography.

Results: Non-significant andsignificant carotid stenosiswere observed in 16 patients (17.0%) and 4 patients (4.3%), respectively. Multivariate logistic regression analysis showed that serum low density lipoprotein cholesterol (LDL-C) level was independently related to the presence of carotid stenosis with Odds ratio as 1.504.

Conclusions: Prevalence of carotid stenosis is high in patients with PCAD in Vietnam. Screening of carotid stenosis should be recommended in these patients, especially in whom with elevated LDL-C.

Key words: Atherosclerosis, carotid stenosis,coronary artery disease, premature.
SOCIAL AND TECHNOLOGICAL CHALLENGES OF THE RUSSIAN ECONOMY
Authors:   VEB.­RF, KLEPACH A.N. ­
Published: October 2021

The Russian economy is recovering faster than previously expected, but it is lags behind i world leaders in growth and scale of social programs. The most acute societal challenge remains low incomes and high social inequalities. For long-term sustainable growth, the transition to a new model of human wealth development, social justice, knowledge and technology economics is crucial. Tight fiscal rules and monetary policies are hampering this transition.
AGENT MODELING OF COMPETITION AND COEVOLUTION OF FINTECH AND REGTECH2 IN THE GLOBAL FINANCIAL ECOSYSTEM: THE RED QUEEN EFFECT
Authors:   Financial University under the Government of the Russian Federation, ILYINSKY A.I.
Published: October 2021

This paper examines the competition and co-evolution of FinTech and RegTech2 in the global financial ecosystem using the methods of evolutionary economics. A simple agent-based model is built on the NetLogo platform and the emergence of cycles of technological dominance in the ecosystem is shown. The paper also discusses the “technological arms race” of regulators and system participants as a result of the co-evolution and competition of two technology groups, known as the red queen effect.
TOPICAL ISSUES OF THE DIGITAL STATE DEVELOPMENT IN RUSSIA
Authors:   Plekhanov Russian University of Economics, KITOVA O.V. ­
Published: October 2021

The important aspects of building a digital state are considered. The structure of a digital state and its main services, an automated system of strategic planning and program-targeted management of the Russian economy are proposed. As the core of such a system, an automated system of planned calculations is proposed for the development and adjustment of long-term, medium-term and current (annual) plans, including a digital service for scenario forecasting of socio-economic indicators of the Russian Federation, developed at the Plekhanov Russian University of Economics under the guidance of the author.
GLOBAL FOOD SYSTEM: DIGITAL ASPECTS OF TRANSFORMATION
Authors:   oscow State Institute of International Relations (University) of the MFA of Russia, REVENKO L.­S. ­
Published: October 2021

The article deals with the problem of digital aspects of the transformation of the global food system. It analyzes the vectors of changes in general approaches to the system and its elements attribute and assesses the role of digital innovation in improving the efficiency of the global food system in the face of deteriorating food security at the global and regional levels. The article emphasizes the ambiguous nature of the impact of digital technologies on the elements of the food system.
DIGITAL TRANSFORMATION OF PUBLIC ADMINISTRATION: MAIN TRENDS AND NEW OPPORTUNITIES
Authors:   Federal State Budgetary Institution of Science - Institute of Economics of the Russian Academy of Sciences, SMOTRITSKAYA I.I.
Published: October 2021

The article reveals the main trends of digital transformation in the field of public administration. The priorities of digitalization of public administration are considered, including the creation of a digital government and the achievement of" digital maturity " of the public administration system by 2030. The characteristics of digital transformations are given from the point of view of improving the efficiency and quality of public administration, the possibilities of digitalization for the development of a public administration model capable of comprehensively solving macroeconomic problems of the country's strategic development are determined.
HAS THE COVID-19 CRISIS PUT PLANNING BACK ON THE AGENDA?
Authors:   CEMI-EHESS, Sapir­ J.
Published: October 2021

The COVID-19 pandemic resulted in the emergence of an unforeseen event with far-reaching consequences. This surprise invalidated the traditional results of economic calculation and made the act of political decision-making emerge as central as the markets proved incapable of handling this type of event. In such a situation, the political decision turns out to be more effective than economic calculation. This is also the case with heuristic decision-making because it becomes impossible to calculate in advance the consequences of the unforeseeable event. In this situation, O. Neurath had shown in the debate with L. von Mises and F.A. Hayek that planning could be an effective alternative to a market. J.E. Stiglitz has stressed the risk of market failures too. It is therefore now clear that the health crisis has revived the issue of planning. The fear of a recurrence of such a pandemic will permanently shape economic behaviour in the years to come. We find empirical applications both in the case of war economies during the two world conflicts and in the Japanese or French post-war economy. Conscious and organized consultation, which can then take the form of a flexible mode of planning such as what was practiced in post-war France or in Japan by the MITI, can then - as Claude Gruson shows - prove to be a procedure that is not only effective but empirically efficient in the face of uncertainty and the inability of the market to manage information effectively.
FORMATION OF A REGIONAL COMPETITIVENESS STRATEGY: ASSESSMENT OF FACTORS AND DESIGN OF RESULTS
Authors:   Pushkin ­Leningrad ­State­ University, EREMEEV S.G. , BOLSHAKOV S.N. ,   Pushkin ­Leningrad ­State­ University
Published: October 2021

The article analyzes the problems of territorial competitiveness. The article reveals the conditions for the formation of competition at the regional level. The objective of the article was to reveal the strategic importance of regional competitiveness. Using the example of the study of the Leningrad region, the authors analyze the cumulative influence of competitiveness factors on the dynamics of the processes of regional development. The article concludes that on the basis of the regional diagnostics, the region forms its competitive profile, develops the basis of the territorial marketing strategy.
THE ROLE AND IMPORTANCE OF RESPONSIBILITY CENTERS IN THE DIAGNOSIS OF FINANCIAL RELATIONS OF AGRICULTURAL ENTERPRISES
Authors:   Rostov ­State­ University ­of Economics, USENKO A.M.
Published: October 2021

On the basis of the generalization of theory and practice, the possibilities of managing agribusiness enterprises with the allocation of responsibility centers are reflected. The article shows that the mechanism of accounting for the responsibility of enterprises of the agro-industrial sector is an integral and mandatory component of the effective operation of the enterprise. The main centers of responsibility are identified, the functions, the most significant principles of cost accounting for places and centers of financial responsibility, as well as the functional relationships and interdependencies of agribusiness enterprises among themselves in various areas of activity are identified. It is proved that the diagnosis and development of effective financial relations at agricultural enterprises and the optimal organization of all processes of activity in the market leads to the expansion of both external and internal financial relations.
A HOLISTIC LITERATURE REVIEW OF BUILDING INFORMATION MODELING FOR PREFABRICATED CONSTRUCTION
Authors: Zhang Shengxi , Li Zhongfu , Li Tianxin , Yuan Mengqi
Published: October 2021

Building information modeling (BIM) and prefabricated construction (PC) are increasingly applied in the construction industry. Recent academic and industrial efforts indicated that the application of BIM and PC is a solution to reduce lifecycle costs, reduce waste, increase productivity and improve quality in construction. Although previous studies have advanced the integration of BIM and PC, extensive research scope and scattered research topics cannot form an overall picture of knowledge structure. Hence, this study aims to establish an up-to-date synthesis of the latest research on BIM for PC and identify the research gaps and future needs. First, a database with 103 journal articles on BIM for PC was established through data collection; second, a bibliometric analysis was applied to determine the top journals, articles and to map the latest mainstream research. Last, a qualitative analysis was used to determine the mainstream research areas and identify the research gaps and future needs. This study may contribute to enrich our body of knowledge on the use of the techniques in conjunction, help researchers and builders to understand the latest progress of BIM for PC research in timely fashion, and promote the integration of BIM with PC and other cutting-edge technologies moving forward.
Androgen Receptor and ETS-Like Protein-1 Expression of Prostate Cancer Correlates with Gleason Score International Society of Urological Pathology 2014/WHO 2016
Authors: Putriyuni Anandia , Tjong Djong , Yanwirasti Yanwirasti , Alvarino Ariana , Tofrizal Tofrizal
Published: October 2021

AIM: Prostate cancer is the second most common and the fifth leading cause of death by cancer in men worldwide now. Grading based on Gleason score is a significant prognostic factor of prostate cancer. Androgen receptor (AR) plays important role in the initiation and progression of prostate cancer. AR signaling pathways in prostate cancer can also promote MAPK/ERK signaling pathways which activate ETS-like protein1 (Elk-1).

METHODS: A total of 56 slides and paraffin blocks sampling of prostate cancer by consecutive from Department of Anatomical Pathology in West Sumatera. Hematoxylin and eosin (HE) stained slides were evaluated to review Gleason score, histopathological grading, and WHO grade group based on International Society of Urological Pathology (ISUP) 2014/WHO 2016. Immunohistochemistry staining of AR and Elk-1 was performed to analyze protein expression.

RESULTS: Prostate cancers were found in mean age 70.68 ± 7.99 years. The most proportion of prostate cancer was Gleason score 9 (44.64%), histopathological grading poorly differentiated/undifferentiated (76.78%), and WHO grade Group 5 (48.21%). The positive expression AR of tumor cells 39 (69.64%) and Elk-1 34 (60.71%). Statistically, these results showed significant correlations of AR (p = 0.009) and Elk-1 (p = 0.012) with Gleason score.

CONCLUSIONS: These results showed complex interactions between AR and Elk-1 initiation and progression of prostate cancer. Both variables indicated a significant correlation with Gleason score so that biomarkers prognostic potentially for prostate cancer.
Thymol Mitigates Monosodium Glutamate-Induced Neurotoxic Cerebral and Hippocampal Injury in Rats through Overexpression of Nuclear Erythroid 2-Related Factor 2 Signaling Pathway as Well as Altering Nuclear Factor-Kappa B and Glial Fibrillary Acidic Protein Expression
Authors: Mostafa Rasha , Hassan Azza , Salama Abeer
Published: October 2021

BACKGROUND: Monosodium glutamate (MSG) is commonly used in various food industries as a flavor enhancer. MSG is reported to cause increased neurotoxicity.

AIM: The study investigates the molecular mechanisms underlying the neuroprotective effect of thymol against MSG-induced neurotoxic cerebral and hippocampal injury in rats.

MATERIALS AND METHODS: Forty rats were allocated to four Groups: I (Normal); II MSG-control (2 g/kg; i.p.); III-IV MSG + Thymol (400 and 800 mg/kg/day; p.o.). All groups were treated for 15 days.

RESULTS: MSG-control group showed a significant reduction in behavioral activity, elevated brain tissue oxidative stress, inflammatory parameters, Nuclear Erythroid 2-Related Factor 2 (Nrf2) gene upregulation, overexpression of nuclear factor-kappa β _(NF-kβ), glial fibrillary acidic protein (GFAP) along with neuronal damage in the cerebral cortex, and hippocampus. Thymol ameliorated MSG-induced brain injury through overexpression of Nrf2 gene, thus increasing the cellular defense and resulting in organized anti-oxidant and anti-inflammatory effects. Thymol improved behavioral activity and brain tissue glutathione content. Thymol also decreased brain contents of malondialdehyde, nitric oxide, tumor necrosis factor-alpha, and interleukin-6. Moreover, Thymol improved NF-kβ _and GFAP immunohistochemical expression besides histopathological picture in cerebral cortex and hippocampus as compared to MSG control rats.

CONCLUSION: These results suggest that thymol exhibits promising neuroprotective effects. The study elucidates the molecular mechanisms linking Nrf2 pathway signaling to oxidative stress, inflammation and NF-kβ _expression underlying thymol’s protection against MSG-induced neurotoxicity. The study also highlights the role of GFAP expression in MSG-induced astrocyte injury of cerebrum and hippocampus of rats and the promising protective effects of thymol in ameliorating astrocyte injury.
The Possible Antidiabetic Effect of Ficus carica L. Tablet on lloxan-Induced Diabetes Model in Rats
Authors: Kurniawan Muhammad Fariez , Yusuf Fadhilah Alvari
Published: October 2021

BACKGROUND: Fig leaves are reported to have an effect on reducing blood glucose levels. However, the use of fresh leaves makes the effects obtained is not measurable and efficient.
AIM: The purpose of this research was to determine the antidiabetic potential of ethanol extract of fig leaves and to optimize tablet dosage formulations.
METHODS: Four tablet formulas were made using the wet granulation method. Formula I (FI), Formula I (FII), and Formula III (FIII) groups to give a tablet of ethanol extract of fig leaves with a dose of 40 mg, 60 mg, and 80 mg and placebo treatment group. There were eight groups of male rats strain Wistar treated as follows: Normal control, negative control, positive control (metformin tablets), basis group, placebo treatment group, F1, F2, and F3 groups. The antidiabetic activity was evaluated from a decrease in rat blood glucose levels. Previously, rats were induced first using alloxan 150 mg/kg intraperitoneally to damage β-pancreatic cells so that the rats could experience increased blood glucose levels. After giving treatment to each group for 14 days, a rat blood sample was then taken on days 9 and 14, which were then analyzed by the GOD PAP method with readings carried out using a spectrophotometer with a wavelength of 500 nm.
RESULTS: The average weight (mg) of FI tablets (617.8 ± 3.21%), FII (629.35 ± 8.16%), and FIII (643.6 ± 6.21%), and placebo tablet (666.45 ± 4.36%). As for the uniformity of size, all formulas have a diameter of 0.9 ± 0.0 (cm). For the hardness values of FI (5.7 kg), FII (1.31 kg), and FIII (3.09 kg), placebo tablet (2.98%). The value of friability FI (1.42%), FII (11.8%), and FIII (0.84%), placebo tablet (1.16%). While the disintegration time of FI (11.02 min), FII (10.10 min), and FIII (17.00 min), placebo tablet (12.23%). As for the uniformity of size, all formulas have a diameter of 0.9 ± 0.0 (cm). Whereas the dissolution rate (DE45) of each formulation decreased with increasing dose of extract, FI (73.73%), FII (74.80%), and FIII (69.80%). The treatment group of the ethanol extract of fig leaves at a dose of 40 mg, ethanol extract of fig leaves at a dose of 60 mg, and ethanol extract of fig leaves at a dose of 80 mg could reduce rats’ blood glucose levels with statistically significant results (p < 0.05) compared to negative group. When it was compared to the positive group, it had significant results with a statistical value (p < 0.05).
CONCLUSION: Ethanol extract of fig leaf tablets had a significant effect on lowering rats’ blood glucose levels.
Histological Changes of Stomach and Intestine Induced by Energy Drink (Tiger) in Adult Male Rats
Authors: Al Sammak Maha , Qassim Ahmed Hisham , Hamdi Omer R.
Published: October 2021

BACKGROUND: Nowadays energy drinks are markedly consumed by young people all over the world but till now there were only few literatures that describe their effect on the stomach and small intestine.

AIM: The aim of the current study is to highlight the histopathological changes encountered in the stomach and small intestine that are induced by energy drinks.

MATERIALS AND METHODS: Thirty adult male albino rats were divided into three groups: a control group given only standard diet and distilled water, a group given a low dose of Tiger energy drink (1 ml/100 mg/rat/day), and a group given a high dose of Tiger energy drink (2 ml/100 mg/rat/day). These drinks were given orally via gastric tube for 1 month duration.

RESULTS: Histological assessment of different sections of the stomach and small intestine has revealed parietal cell hyperplasia with congestion of gastric mucosal blood vessels, moreover partial loss of intestinal villi with goblet cell hyperplasia was observed in group treated with low dose of Tiger. Increasing the dose of this drink resulted in mononuclear cell infiltration associated with goblet cell metaplasia which could be an early marker for gastric cancer, furthermore complete loss of intestinal villi and degenerative changes of epithelial cells were seen in intestinal sections. These pathological changes seem to be dose related.

CONCLUSION: There is a high risk on the rat’s stomach and small intestine in chronic consumers of energy drinks particularly when taken with no limits. Further work is recommended to delineate the exact mechanism of the pathological findings induced by energy drinks.
Level of Interleukin-35, Interleukin-36, and the Interleukin-35/Interleukin-36 Ratio in Juvenile Idiopathic Arthritis
Authors: Jamal Qudus W. , Alubaidi Ghassaq , Humadi Yasmin
Published: October 2021

BACKGROUND: Cytokines are inflammatory mediators that regulate multiple processes potentially implicated in inflammation and autoimmunity.

AIM: This study aimed to investigate the levels of circulating interleukin (IL)-35, IL-36, and IL-35/IL-36 ratio in Juvenile Idiopathic Arthritis (JIA) patients.

METHODS: Fifty-one patients categorized based on the International League of Associations for Rheumatology classification criteria were enrolled, along with 46 healthy controls. Disease activity assessment was conducted according to the Juvenile Arthritis Disease Activity Score (JADAS-27) system. Serum cytokine levels were determined using the sandwich enzyme-linked immunosorbent assay.

RESULTS: Compared to controls, the serum levels of IL-36 were significantly higher among JIA children (p = 0.002), and serum IL-35 levels and the IL-35/IL-36 ratio were significantly lower in the patients (p = 0.002, p < 0.001, respectively). Furthermore, the IL-35/IL-36 serum ratio, but not the absolute IL levels, correlated positively with the JADAS-27, giving a good indication of the disease outcome. Further, the IL-35/IL-36 serum ratio showed higher sensitivity and specificity compared to the absolute cytokine levels.

CONCLUSION: A significant change in the circulating IL-35 and IL-36 levels and an imbalance in the IL35/IL36 ratio occur in JIA. This study is a novel attempt to explore the role of IL-35 and IL-36 in JIA; further studies are required to support our results. The IL-35/Il-36 ratio is a promising immunological marker to predict, diagnose, and monitor JIA.
Denosumab Does Not Decrease Local Recurrence in Giant Cell Tumor of Bone Treated With En Bloc Resection
Authors: Tsukamoto Shinji , Mavrogenis Andreas F. , Tanaka Yuu , Kido Akira , Kawaguchi Masahiko , Errani Costantino
Published: October 2021

We performed a systematic analysis of existing studies to determine whether preoperative denosumab reduces the risk of local recurrence for patients with giant cell tumor of bone treated with en bloc resection and to address the optimal duration of preoperative denosumab with respect to the risk of local recurrence after en bloc resection. Denosumab did not decrease the risk of local recurrence after en bloc resection; the proportion of patients with local recurrence was 3.6% (2 of 56) in the en bloc resection with preoperative denosumab group vs 14.2% (40 of 280) in the en bloc resection alone group, with an overall pooled odds ratio of 0.76 (
P
=.67). Meta-regression models revealed no association between the duration of preoperative denosumab and the odds of local recurrence after en bloc resection (
P
=.83). Administration of denosumab for 3 months before en bloc resection is appropriate for sufficient bone hardening to reduce tumor cell spillage and does not result in denosumab-related complications. [
Orthopedics
. 2021;44(6):326–332.]
Using Feasibility Data and Codesign to Refine a Group-Based Health Literacy Intervention for New Parents
Authors: Muscat Danielle M. , Ayre Julie , Nutbeam Don , Harris Anne , Tunchon Lynette , Zachariah Dipti , McCaffery Kirsten J.
Published: October 2021

Few health literacy interventions exist for new parents. We developed a group-based health literacy program (“Parenting Plus”), which was initially tested in a feasibility study in 2018. In this brief report, we describe how feasibility findings were incorporated into the Parenting Plus program. Using a codesign process with patient partners (feasibility study participants) and health staff to revise the program, version 2 was tested in a single-site pilot using pre- and post-intervention testing. Parents older than age 16 years whose child was between ages 4 and 26 weeks were recruited from nurse home visits in western Sydney, Australia. Interested participants attended the free 4-week health literacy program (four 2-hour sessions) delivered by a trained facilitator. Piloting suggested the revised program is acceptable to new parents, has good retention (93% over the course of 4 weeks), and can improve health literacy skills, including access to reliable health information and services. Our iterative development and codesign approach integrated learnings from various sources to inform the design of an evidence-based health literacy intervention. We now move to an effectiveness implementation hybrid trial to test intervention effectiveness (health literacy skill development) and support translation of research findings into routine practice.

[
HLRP: Health Literacy Research and Practice
. 2021;5(4):e276–e282.]