bluuebunny/crossref_metadata_2025 huggingface dataset:
Vladimir Nikolaevich Derevenko — without the honour's loss
Authors: Ronzhin S. G. , Nekrylov S. A.
Published: June 2020

The thorny and mystery full course of life the fine Russian surgeon, professor Vladimir Nikolaevich Derevenko, the course became the subject of historical discussion and different fictions sequel to attract attention of the investigators multitude. In important measure it connected with the close relations between the doctor and the last Russian emperor's family right up to fatal death on July of 1918. It necessary, to note the scantiness of authentic biographical facts, presented in accessible sources and literature. This publication competently extended the personal biographical state in the context of dramatic Russian history.
Prolegomena to the medical pathogenetics
Authors: Puzyryov V. P.
Published: June 2020

The lecture is addressed to clinicians who state for medical students the problems of genetic mechanisms of human diseases (medical pathogenetics). Epistemological and didactic aspects of interpretation of the «human genome» concept are considered, as well as Davidenkov—McKusick principles of clinical genetics, classification of hereditary human diseases, and problems of application of new genetic knowledge to medicine (translational medicine).
Study of the IL-4 and IL-4δ2 interaction with the IL-4R receptors of the I and II types in silico and the effect on the functional activity of mononuclear cells in vitro
Authors: Goremykin K. V. , Silkov A. N. , Shilov B. V. , Serebrov V. Yu. , Sazonov A. E. , Sennikov S. V.
Published: June 2020

Alternatively spliced interleukins are very actively studied over the last years. Splice form of IL-4 — IL-4δ2 has antagonistic effects to its full form on proliferative activity of human mononuclear blood cells and their IL-6 production. Antagonistic effects between IL-4 and IL-4δ2 were confirmed and explained in this study due to combination of biochemical and computer methods.
Intrahepatic hemodynamics in children with dynamic and inflammatory cholepathias
Authors: Semenyuk L. A. , Bychkova N. K.
Published: June 2020

Ultrasound dopplerography can reveal minimal disfunctions of intrahepatic hemodynamics. Linear speed of hepatic artery and hepatic vein (peak S and D) rises in the presence of dynamic and to a greater extent organic (inflammatory) cholepathias. The increase of blood flow speed occurs when vessel radius expands. This phenomenon can be explained by dilation of intrahepatic vessels which is more defined when the matter concerns inflammatory cholepathias and less defined among dynamic ones. Indices of intrahepatic hemodynamics may serve as indirect signs of given diseases among children and may reveal pathology on the earliest stages of its development.
Cerebral ischemic stroke as demonstration early neurosyphilis
Authors: Komkina N. G. , Nazarenko N. V. , Nazarenko T. V.
Published: June 2020

Specific defeat of vessels of a brain at a syphilis can be one of the stroke reasons. The results of retrospective analysis of 53 case records of patients early manifest by forms neurosyphilis are resulted in article. The first group included the patients who were not receiving specific therapy concerning a syphilis, the patients treated earlier concerning a syphilitic infection have been included in another. From the given groups patients with cerebrovascular forms of neurosyphilis (only 24) have been allocated. The diagnosis has been verified on the basis of the clinical data, results clinic — laboratory and serologikal researches of whey of blood and liquor, the data of a magnito-resonant tomography, dopplerography researches of a brain blood-groove, compression, hypercapnia tests. Features of a clinical current cerebrovascular forms early neurosyphilis with stroke a current are revealed.
Influence of the previous antihypertensive therapy on the course of cerebral stroke
Authors: Kolchu I. G. , Volchenkova T. V. , Isakova Ye. V. , Kotov S. V.
Published: June 2020

Influence of the previous antihypertensive therapy on the course of cerebral stroke was analyzed in 188 hypertensive patients. Stroke course features and treatment outcome were analyzed in patients receiving regular antihypertensive therapy before stroke and in those not treated or treated irregularly. Direct influence of previous antihypertensive therapy on the rate of hemorrhagic stroke development, its course severity, and subsequent functional recovery was revealed.
Сonstitucional features of ischemic stroke patients with concomitant cardiac pathology
Authors: Oleksyuk N. V. , Kuryachenko Yu. T.
Published: June 2020

Identification of influence of cardiac pathology on the course of ischemic stroke in patients with different types of constitution, can play an important role in the tactics of treatment and prognosis. The assessment of neurological status in the acute period of stroke depending of the type of cardiac pathology and constitutional features, evaluation of hemostasis was performed. A positive correlation between the existed cardiac pathology with some anthropometric somatotype parameters and their influence on adverse outcome of stroke was revealed.
Tick-borne viral encephalitis in the Tomsk Region for the last decade
Authors: Udintseva I. N. , Poltoratskaya T. N. , Shikhin A. V. , Poponina A. M. , Zhukova N. G. , Lukashova L. V. , Malysheva L. A.
Published: June 2020

In the given work had been lead the analysis of epidemiological data TBE for 1999—2009 on Tomsk area. The information on quantity imparted against tick-borne encephalitis, about results of research of pincers and blood at the persons who have addressed on points prevention of tick-borne encephalitis and about quantity of the diseased tick-borne encephalitis is presented. Analysis of a complex of preventive actions is spent. The reasons of formation of the long maintenance of a virus tick-borne encephalitis in blood are shown.
Differential diagnosis of the multiple focal lesions and expansive process of brain in early stage of the disease
Authors: Fonin V. V. , Gribachyova I. A. , Dergilev A. P.
Published: June 2020

Differential diagnosis of the multiple focal lesions and expansive process of brain was conducted in 78 patient in early stage of the disease when it was mono symptom clinic. Only MRI helped to make the proper decision.
Complex approach in the treatment and rehabilitation of the patients with myofascial face pain syndrome
Authors: Brega I. N. , Doronin B. M. , Adoniyeva A. V.
Published: June 2020

Determination the tactics of the treatment and rehabilitation of the patients with myofascial face pain syndrome (MFFPS). The complex of clinical and radiologic diagnostic methods to 83 patients with myofascial face pain syndrome and mandible movement disorder have performed. Patient examination have made it possible for to define succession and efforts, to reduce pain syndrome intensity, to normalize mandible movements. MFFPS treatment requires the participation of stomatologist, neurologist, roentgenologist, psychologist, therapeutist.
Cognitive impairment in patients with Parkinson’s disease
Authors: Zhukova I. A. , Zhukova N. G.
Published: June 2020

Parkinson’s disease (PD) is a progressing neurodegenerative disorder is exhibits clinically by bradykinesia, tremor, rigidity, and postural instability. Cognitive impairment were observed in 88,8% patients: mild cognitive impairment in 36,1% and dementia — in 63,9% patients.
Dynamics of quality of life indicators at a multiple sclerosis
Authors: Karnaukh V. N. , Lugovtsova Yu. A. , Barabash I. A.
Published: June 2020

The study explored the life quality of 94 multiple sclerosis patients in comparison to healthy respondents and in dependence to different parameters of the disease with the use of SF-36 questionnaire. The study has discovered a decline of all the factors of life quality and their dependence on disablement intensity, clinical course and duration of the disease. Immunomodulatory therapy contributed to the improvement of life quality factors.
Neuropshycological recovery dynamics in patients with ischemic stroke and alcoholic encephalopathy
Authors: Kladova Ye. A. , Doronin B. M.
Published: June 2020

Examination of recovery dynamics of cognitive impairments in patients with ischemic stroke and with or without alcoholic encephalopathy was conducted. It was shown that in patients with ischemic stroke and alcoholic encephalopathy dementia prevails, and positive dynamics is extremely rare.
Clinical and epidemiological characteristic of epilepsy in children and teenagers in Tomsk Region
Authors: Krayeva L. S. , Alifirova V. M.
Published: June 2020

The incidence of epilepsy and epileptic syndromes (number of new cases per year in a given population) in children and teenagers of Tomsk Region was 44.10 per 100 000 people, being higher in children (49.60) as compared to teenagers (27.39). The prevalence (number of active cases per unit population) was 3.53 per 1 000 people and differs among regions (from 0.74 to 10.95). Most of patients suffered from symptomatic (45.58%) focal epilepsies with predominantly temporal lobe epilepsies (42.04%). The most common etiologic factors of symptomatic focal epilepsies were hypoxic-ischemic perinatal encephalopathies and developmental brain disorders (15.9%). 24.26% patients were switched to politherapy, and others — to monotherapy. Valproates were most often used drug. Remission was achieved in 49.43%.
Headaches and its dependence from different factors in patients with temporal epilepsy at interictal period
Authors: Kurus O. S. , Nadezhdina M. V. , Osintseva Ye. V. , Skulskaya N. I.
Published: June 2020

56 patients with temporal epilepsy (TE) at the age of (30.5 ± 10.0) years under the duration of the disease — (17.5 ± 10.7) years are examined. The examination included the anamnesis, somatic and neurological statuses, ultrasonic medical examination of brain vessels, the magneto-resonance tomography (MRI) of brain. Headaches (HA) among 80.4% patients with TE is revealed and its dependence from different factors is studied. The absence of gender differences, the dependence from the type TE, frequency of attacks and the duration of the disease among patients TE with HA are noticed, however the burdened neurological and obstetrical anamnesis, the presence HA among relatives, changes on data MRI of the brain, pathology of vertebral-basilar basin, the reduction and asymmetry of the index of the vessel resistance are observed. This amends the algorithm of the examination and treatment of patients with temporal epilepsy.
Diagnosis of classic trigeminal neuralgy
Authors: Balyazina Ye. V.
Published: June 2020

Spiral CT angiography was used for identify position the top of the loop of the superior cerebellar artery (SCA) in 23 patients classical trigeminal neuralgia (TN). The author describes the defining point, expressed as the position of the loop of the SCA in relation to the root of the trigeminal nerve (RTN) projection. In all 23 observed cases of patients with classical TN the apex of the loop of SCA was located lower of the RTN projection, which confirmed pathogenic role of neurovascular conflict in TN.
The hygienic assessment of modern sources of light
Authors: Andropova T. V. , Volkotrub L. P.
Published: June 2020

This article summarizes the current state of electric lighting systems. Comparing characteristic of different electric sources of light allows to reveal there technical, economical and hygienic advantages. There have been recommended the spheres of application of main types of electric light sources.
Recurrent goitrous transformation and postoperative hypothyroidism — the arguments to execution of organ-preserving thyroid sergery
Authors: Galyan A. N. , Popov O. S. , Tikhonov V. I. , Zavadovskaya V. D. , Gasparyan S. N. , Udut V. V.
Published: June 2020

The study included 557 patients with diffuse nodular colloidal goiter and different functional state of thyroid gland after routine surgeries. In the postoperative period was diagnosed hypothyroidism and in its presence the relapse nodulation in thyroid residue. In order to prevent the development of postoperative hypothyroidism, organopreserve surgical methods of the local cryodestruction of pathologic area thyroid gland and autotransplantation of intact thyroid tissue were suggested.
Diagnostic aspects of osteopenic syndrome in Type 1 pancreatic diabetes patients
Authors: Tonkikh O. S. , Samoilova Yu. G. , Zavadovskaya V. D. , Kravets Ye. B. , Kilina O. Yu. , Kriulko L. A.
Published: June 2020

The condition of a bone fabric at 102 sick diabetes mellitus type 1 (48 men and 54 women, middle age (38,2 ± 12,2) years) is studied, also are specified influence of various factors on development osteopenic syndrome. Research methods included clinical and history of development of disease, beam, biochemical, statistical methods of processing of results. As a result of research it has been revealed that indicators of bone durability at sick of a diabetes corresponded osteopenia which was accompanied by infringement micro-arhcitecture bones in the form of decrease in relative volume trabecular bones and quantities trabecula. Osteosonographie it was accompanied by changes of markers of a bone metabolism (osteocalcin and C-trailer tilopeptid) testifying to activation of processes osteolysis at sick of a diabetes.
Hemofiltrocytodiagnosis as a morphological method of malignant neoplasm detection
Authors: Chimitov A. A. , Dambayev G. Ts. , Perinov A. P. , Khankhashanova T. D. , Medvedev V. I. , Ryazantseva N. V.
Published: June 2020

The potential of application of patients’ venous blood hemofiltrocytoanalysis has been presented in the article. An innovative device for blood micro-screening enables specialists to withdraw cancer cells from patients’ blood and diagnose during the very first consultation.
Peculiarities of pathology cardiovascular system in liquidators or cleanup workers at the Chernobyl Nuclear Power Station to data of cardiology hospital
Authors: Telkova I. L. , Vnushinskaya M. A. , Kapilevich L. V.
Published: June 2020

Peculiarities in epidemiology and clinical course of main cardiovascular diseases: arterial hypertension (AH), atherosclerotic and microvascular forms of ischemic heart disease (IHD), and their outcomes in liquidators or clean-up workers at the Chernobyl Nuclear Power Station have been considered based on the data of specialized cardiologic survey and prospective 25-year observation of the revealed pathology. It has been shown that the ionizing radiation in small doses under certain conditions can be considered as one of starting mechanisms of the system vascular disfunction facoring the development of AH and IHD. It has been found that their further pathogenesis and outcome in liquidators are ultimately determined by the quality and character of the primary and secondary prophylaxis aimed at the correction of the following life style and working conditions, as well as by the timely administration of pathogenic therapy.
Initial stage of development of heliobiology in Russia (biography of Petr Mikhailovich Nagorsky)
Authors: Nagorsky P. M. , Alyab'ev F. V. , Osipov A. I. , Shamarin Yu. A. , Poverinov S. N. , Skobtsov A. P.
Published: June 2020

The paper describes the biography of Petr Mikhailovich Nagorskii, one of the founders of Russian heliobiology. The most important stages in his life: childhood, learning in seminary and medical university, work at a chair of pathological anatomy, field duty, and then return to the university and beginning of scientific research, are described. Scientific results of heliobiological research with the use of a lead chamber are described.
Platon Ivanovich Tikhov, Professor of Surgery of the Imperial Tomsk University (to 145th anniversary)
Authors: Fyodorova G. V. , Scherbakov D. V.
Published: June 2020

The number of publications devoted to the development of medicine in Siberia is increasing in the last years, but still insufficient. In this paper, the authors tried to reconstruct the biography of Platon Ivanovich Tikhov, Professor of the Tomsk Imperial University, whose results enriched the Russian and international surgical science in the field of osteoplastic operations, surgery of abdominal cavity and parenchymal organs, blood vessels and heart, anaesthetization. P.I. Tikhov was the first in Siberia, who performed the heart wound closure operation (1907).
Efficiency of application of antioxidants from group sterically hindered phenols by retina photodegradation
Authors: Zhdankina A. A. , Plotnikov M. B. , Kon G. A. , Ivanov I. S. , Varakuta Ye. Yu. , Kuchin A. V. , Chukicheva I. V. , Logvinov S. V.
Published: June 2020

Renoprotective effect of antioxidants from group sterically hindered phenols (thiophane, dibornol) in white nondescript male rats (n = 55) subjected to influence of light intensity level 6 000 lx during 6 h was demonstrated. Course intragastric administration of thiophane limited of destructive changes in the retina, but didn’t bring to disappearance of lesion focuses. Dibornol prevented progression of local changes in the retina, contributed to decrease destruction of neurosensory cells, pigment epithelium and neurons of internal layer.
Anthropometric indices significance for body fat assessment in adolescents
Authors: Ivanova I. V. , Chyornaya N. L.
Published: June 2020

In order to distinguish anthropometric indices significance for body fat assessment anthropometry and bioimpedanceometry were made in 620 schoolchildren. Maximal correlation with body fat was revealed for BMI (r = 0,86). Significance of BMA in overfat diagnosis was 81,5%, specifity was 94,8%. BMA should be recommended for indirect body fat assessment during prophylactic observations in adolescents.
The abatement of local mucosal immunity as the factor of nasal polyposis recidivation
Authors: Kologrivova Ye. N. , Starokha A. V. , Pleshko R. I. , Isayev P. Yu. , Kovalyova M. A.
Published: June 2020

Assessment of the role of mucosal immunity in nasal polyposis recidivation was carried out. The density and the composition of inflammatory infiltrate in polyps from the patients with the primary and the recurrent nasal polyposis were researched. In nasal lavage the composition of the cells and the content of interleukin-4 and interferon-γ were estimated. It was shown that the polyposis recidivation occurs during the progression of local immune insufficiency.
Effect of reserved line’s anti-tuberculosis medicines to antiinflammatory cytokine production for patients with pulmonary tuberculosis
Authors: Kononova T. Ye. , Urazova O. I. , Serebryakova V. A. , Novitsky V. V. , Vasiliyeva O. A. , Naslednikova I. O. , Voronkova O. V. , Khasanova R. R. , Kolosova A. Ye.
Published: June 2020

The results of research show the impact of ofloxacin, para-aminosalicylic acid (PASA) and capreomycin in conjunction with the BCG vaccine strain to the cytokine-production ability of mononuclear peripheral blood leukocytes for patients with infiltrative pulmonary tuberculosis prior to specific antituberculosis therapy. The results show that ofloxacin has inducing effect on the secretion of interleukin (IL) 4 and transforming growth factor (TGF) β; PASA and capreomycin have such effect for the products of IL10 and TGFβ. This influence has a negative effect during the active development of the pathological process and during specific treatment.
The thin-profile fiber use on the basis of the titanium nickelid for diaphragm extensive defects substitution
Authors: Dambayev G. Ts. , Popov A. M. , Gyunter V. E. , Khodorenko V. N. , Topolnitsky Ye. B. , Baikov A. N. , Semichev Ye. V.
Published: June 2020

The analysis of experimental studying of new ways of diaphragm extensive defects substitution using fabric on the basis of material made of titanium nickelid alloy has been performed. Carried out beam monitoring and studied histologic preparations. Results have shown that implanted into the organism devices of titanium nickelid are deformed in accordance with regularity of organism tissue elastic behavior thus providing with harmonious functioning of the whole system «implanted tissue — organism».
Effect of hydrogen sulfide on the contractile activity of smooth muscle cells from the rat aorta
Authors: Baskakov M. B. , Gusakova S. V. , Zheludeva A. S. , Smagly L. V. , Kovalyov I. V. , Vtorushina T. A. , Nosov D. S. , Yeryomenko K. V. , Medvedev M. A. , Orlov S. N.
Published: June 2020

In preparations of rat aorta, used as a model of muscular type arteries, the method mehanografii studied the effect of hydrogen sulfide on the reduction of isolated of vascular smooth muscle. Found that hydrogen sulfide in concentrations 1—50 mmol increases the mechanical stress of smooth muscle in high-K + medium. At higher concentrations (300—1 000 mmol) H2S leads to lower amplitude giperkalievoy contraction in high-K + medium. Reduction of smooth muscle cells caused by phenylephrine inhibited the action of hydrogen sulfide in the whole range of concentrations. The causes of differences in data obtained with the results of studies in other laboratories, and possible mechanisms of action of hydrogen sulfide on the contractile activity of vascular smooth muscle.
Pelotherapy and magnetic field in combined treatment of bronchial asthma patients with accompanying gastrointestinal pathology
Authors: Zaripova T. N. , Simagayeva N. N. , Antipova I. I. , Anichkina O. A. , Shakhova S. S. , Yuriyeva N. M. , Kuzmenko D. I.
Published: June 2020

We report a developed treatment technique with the use of physical factors for treatment of bronchial asthma patients with accompanying gastrointestinal pathology. A total of 129 patients were divided into three groups by the method of treatment: 1st (main) group (53 patients) received peaty mud applications and traveling magnetic field (TMF), 2nd group (45 patients) received TMF, and 3rd group (31 patients) received peaty mud applications. The study of the dynamics of clinical pattern, biochemical, immunological, functional, and endoscopic data has shown the efficiency of the combined application of pelotherapy and TMF, which exert the positive effect on the main and accompanying diseases and provide high immediate and long-term results of treatment.
Myocardial tissue doppler imaging in studying of change in the longitudinal right ventricular function in patients with chronic obstructive pulmonary disease
Authors: Ivanova N. G.
Published: June 2020

The obstructive of paper was to study and match clinical symptoms of chronic obstructive pulmonary disease, laboratory and instrumental analyses data, and data obtained from myocardial Tissue Doppler Imaging. Sixty four patients four patients with chronic obstructive pulmonary disease were examined. It was discovered that information obtained through myocardial Tissue Doppler Imaging is in fact early evidence of pulmonary heart disease available at the pre-clinical stage (functional changes are observed before clinical symptoms).
The principles of drug gastroduodenal bleeding prevention in critically ill condition patients and in postoperative period patients
Authors: Sorokina Ye. A. , Loyenko V. B. , Morova N. A. , Kopeikin S. A. , Safechuk V. V.
Published: June 2020

The basic pathogenic mechanisms of ulcer formation in critically ill condition patients and in postoperative period patients are studied in the article. The role of central nervous system, humoral effects, drug aggression, system inflammatory response and also acid peptic factor as a key mechanism of damage is introduced. The basic reasons for preventive maintenance of the gastroduodenal bleedings is represented considering the character and degree of disease, time of hardwired vital functions replacement, presence of further diseases. The conception is developed, which assuming the proton pump inhibitors application for a long time (till one month) in two phases (intravenous and peroral) for prevention of stress relative gastroduodenal mucosal damage and its consequences.
Perioperative period in surgery of a burn scarring stenosis of the esophagus
Authors: Koshel A. P. , Mosolkov V. Yu.
Published: June 2020

Overall and treated 27 patients aged 41 to 66 with burn scarring strictures of the esophagus. All the patients were divided into 2 groups: 1-st group consisted of 17 patients, who in perioperative period recieved enteral feeding by the jejunostomy in clinic modification; 2-nd group (n=10) had total parenteral nutrition. The resalts of investigation indicated that enteral feeding by the areflux jejunostomy possesses all advantages of parenteral nutrition, reduces number of complications, cuts the time of hospital stay.
Gas attack or gently, the gases!
Authors: Baskakov M. B. , Yusubov M. S.
Published: June 2020

The article contains the current understanding of gas communication in smooth muscle cells, the basic mechanisms of action of gaseous transmitters, analyzes the different views on the nature of the endothelial relaxing and endothelial hyperpolarizing factors. We discuss the controversial issues of the mechanisms of endothelium-dependent relaxation of vascular smooth muscle.
Gordey Maksimovich Iosifov (to the 140 anniversary)
Authors: Saveliyeva L. V. , Grigoriyeva L. A. , Danilchuk R. V. , Melchikova N. M.
Published: June 2020

Submitted biography of professor Gordey Maksimovich Iosifov — founder of the national lymphology, head of the chair of normal anatomy of the Imperial Tomsk University has been presented.
Techniques of formation dangling anastomosis in stomach surgery
Authors: Dambayev G. Ts. , Abilov Ch. K. , Skidanenko V. V. , Soloviyov M. M. , Baikov A. N. , Semichev Ye. V.
Published: June 2020

The original technique of distal resection of a stomach with formation of a muscular cuff and the hanging down valve from own tissues of a stomach in area of gastroduodenal anasthomosis is offered in article. This allows to avoid development of postgastroresectional complications. Materials of investigations out on 26 experimental mongrel dogs. The results of dynamic observation and instrumental methods of the studies have shown functional full value of the formed anastomosis.
Dendritic cells and cytokines in skin in atopic dermatitis
Authors: Denisov A. A. , Klimov V. V. , Logvinov S. V. , Zagreshenko D. S. , Osikhov I. A.
Published: June 2020

To study CD1a+ Langerhans cells and their extensions in epidermis and values of IL-4, IL-10, IL-17 and IFN-g in cell-free skin exudate there have been examined 40 patients of atopic dermatitis depending on phase pathological process. There have been found an increase in both CD1a+ dendritic extensions in medium layer of the epidermis and IL-4 and IL-10 in skin exudates. IFN-g exudate’s value has been decreased.
Role of cytoskeleton in formation of airway muscle activity in the presence of nanosized magnetite
Authors: Zaitseva T. N. , Nosarev A. V. , Diyakova Ye. Yu. , Kapilevich L. V. , Ageyev B. G. , Ogorodova L. N. , Magayeva A. A. , Terekhova O. G. , Iteen V. I.
Published: June 2020

The mechanographic method was used to study the influence of iron oxide nano-powder on airway muscle activity in guinea pigs. Under the action of nanomaterial on isolated segments, amplitudes of cholinergic and histaminergic contractile reactions increased. The pre-processing of cytoskeleton by colchicines and nocodazole disintegrators led to an increase in the mechanical stress of segments under the action of carbacholine and histamine.
MRI-biometrical study of intracranial CSF spaces in fetuses with different CNS pathology
Authors: Korostyshevskaya A. M. , Zavadovskaya V. D.
Published: June 2020

The retrospective analysis prenatal magnetic-resonance investigation with cerebrospinal fluid (CSF) biometry in control group and in cases of different fetal brain pathology have been done. Ventriculomegaly prevalence, grade and asymmetry were established. Depicted peculiarities of CSF spaces relations showed to be distinctive for different groups of brain pathology.
Morphological changes of mucous membrane of maxillary sinus at odontogenic perforative sinusitis
Authors: Baydik O. D. , Logvinov S. V. , Zubarev S. G. , Sysolyatin P. G. , Gurin A. A.
Published: June 2020

Methods of light, electronic microscopy and immunohystochemistry lead research of structural changes of a mucous membrane maxillary sinus at 43 patients with odontogenic perforative sinusitis. The material is broken into 4 groups depending on a limitation period of punching. Degenerate changes ciliated epithelial cells came to light already on early terms after perforations of sinusitis and were shown by reduction of specific volume of mitochondrias, the GER, increase NCR. In globlet exocrine cells reduction NCR is connected to infringement of evacuation of a secret. In terms more than 3 months occured metaplasia of epithelium in single-row cubic and multilayered flat with keratosis, increased cellular infiltration own plate of a mucous membrane maxillary sinus. The contents of CD4 + cells in a mucous membrane of sine gradually increased, and on late terms of occurrence of perforations decreased. The contents of CD8+ and СD20+ cells in a mucous membrane with perforations of sinusitis were raised.
Dynamics of gas evolutions in patients with a heavy bronchial asthma on a background of basic anti-inflammatory therapy
Authors: Krasnobayeva L. A. , Selivanova P. A. , Starovoitova E. A. , Kulikov Ye. S. , Kirillova N. A. , Kistenev Yu. V. , Mochula A. V. , Mochula O. V. , Ogorodova L. M. , Fokin V. A. , Bazhin S. I. , Eidenzon D. V.
Published: June 2020

Because of the shortcomings of existing methods of assessment of asthma severity, the method of laser opto-acoustic spectroscopy was considered using for this purpose. Findings results show the availability of this method for diagnostics of clinical course severe asthma.
Effect of chemical production anthropogenic factors on human hepatogenesis
Authors: Ponomaryov B. L. , Obukhova L. Ye. , Vysotsky Yu. F. , Barsukova N. I. , Cherdantseva T. M.
Published: June 2020

The subjects of the electronic microscopy exploration are hepatogenic features of human embryos and fetuses after exposing pregnant women to harmful substances of chemical industry. Malformation of liver blood capillaries and alteration of structural organization of hepatocytes are identified. Tire manufacturing anthropogenic factors are the reasons of organelle membranes alteration. They affect nuclei of hepatocytes, influence the nuclear chromatin, and decrease cell mitotic activity.
Effect of papaverine hydrochloride solution on survival rate of neural-island flap in experiment
Authors: Baytinger A. V. , Yezhov A. A.
Published: June 2020

The neural-island flap is based only on a nerve and survives by intra-and extraneural vessels. Effect of a 2% solution of a papaverine on survival rate of neural-island flap was studied in research. The predominating role of a nerve in survival rate of a flap has been proved. Application by a papaverine doesn't render authentic influence on flap survival.
Influence of meadowsweet ordinary (Filipendula vulgaris) extract on behavior in models of anxiety
Authors: Kaygorodtsev A. V.
Published: June 2020

Influence of water and water-ethanol extracts of meadowsweet ordinary on behavior of albino mice in anxiety models is studied. Anxiolytic action of extracts estimated on animals behavior in an elevated plus-maze, an «open field» and in the test of emotional reaction. It was defined that water and 95% water-ethanol extracts of meadowsweet ordinary render the most expressed anxiolytic action and surpass in activity an valerian extract.
Level amputation definition of the lower limbs by means of a technique identification of muscles ischemic damages in a chronic critical ischemia patients
Authors: Kochubey V. V.
Published: June 2020

Results of application of a technique identification of ischemic damages of muscles are described, confirming its reliability for a choice of level of amputation concerning a chronic critical ischemia.
The genotypical characteristic of M. tuberculosis — aetiological agents of acute progressive destructive pulmonary tuberculosis
Authors: Voronkova O. V. , Urazova O. I. , Khasanova R. R. , Novitsky V. V. , Churina Ye. G. , Naslednikova I. O. , Filinyuk O. V. , Serebryakova V. A. , Kolobovnikova Yu. V.
Published: June 2020

The results of 77 M. tuberculosis clinical isolates genetic typing, allocated from patients with extensive destructive infiltrative and disseminated pulmonary tuberculosis are presented in the article. It is established that among genetically non-uniform Mycobacterium tuberculosis strains, circulating in Tomsk and the Tomsk Region, and causing acute progressive destructive pulmonary tuberculosis, 19% show multi drag resistance. Beijing family strains make 27% from the general population, have a high clusterization index (74%), level of their multi drag resistance in 3 times exceeds that at «not Beijing» strains for which the share of clustering strains makes 11%.
Possibility of drug-free correction of biliary system disorders in employable patients with chronic stress and neurosis
Authors: Poddubnaya O. A. , Ugolnikova O. I. , Levitskaya T. Ye. , Skurlatova I. G. , Lyapunova I. Yu.
Published: June 2020

In the clinical practice, an increase in the efficiency of combined treatment of employable patients with biliary system diseases working under adverse conditions and having chronic stress and neurosis is very urgent. The use of drug-free treatment including antistress measures is justified. Tentative results are indicative of the positive effect of this approach on the functionnal state of biliary system organs with reduction of neurosis and state anxiety and with increase in the index of psychological weightness.
Clinical aspects of pathogenetic influences defining the immune response in patients with urgent surgical pathology
Authors: Sarap P. V. , Vinnik Yu. S. , Ostanin A. A.
Published: June 2020

Using methods of factorial analysis the values of the main components (MC) defining a condition of various links of immune system in patients with urgent surgical pathology are calculated. MC interrelations with clinical characteristics describe qualitative structure of the factors influencing the organization of immune system indicators. Results of research can be used for forecasting of diseases current and a choice of effective tactics of treatment.
The variation of respiration biomechanics and high resolution computed tomography indices when analyzing chronic obstructive lung disease
Authors: Ekkardt E. V. , Bodrova T. N. , Tetenev F. F. , Rodionova O. V. , Ivanova N. G.
Published: June 2020

The aim of the research was to determine how chronic obstructive lung disease clinical signs with lung ventilation function disturbance to various degrees correspond to respiration biomechanics and high resolution computed tomography indices. It was revealed that respiration biomechanics indices are changed at the early stages of chronic obstructive lung disease formation.
Biometric and technologic aspects of experimental technologies in mandible endografting with composite TiNi-based materials
Authors: Dyuryagin N. M. , Sysolyatin P. G. , Tazin I. D. , Dyuryagina Ye. N. , Gunther E. V. , Baidik O. D.
Published: June 2020

Mandibular defect experimental endografting has been performed with the use of composite TiNi-based materials. An ability to create the artificial alive biological models was proved to act high-efficiently in the mandible perpetually. When designing the reconstructive mandibular models made of TiNi-based material for longlife usage it’s to be complied thoroughly the methodology and technology of individual approach. Experimental research results are recommended for investigation and application when creating anthropological mandibular models in the wide clinical practice.
The experience of oxalate nephrolithiasis therapy by sodium pyrophosphate in experiment
Authors: Zharikov A. Yu. , Zverev Ya. F. , Lampatov V. V. , Bryukhanov V. M. , Azarova O. V. , Talalayeva O. S. , Kudinov A. V. , Motin Yu. G.
Published: June 2020

The aim of the investigation was studying sodium pyrophosphate’s effect on experimental oxalate nephrolithiasis.

Experimental nephrolithiasis modeling by using of 1% ethylenglycole’s solution as a drink for rats during 6 weeks. First group was control. In the second group since the third week was being administrated sodium pyrophosphate in dose 2 g/kg. Was detecting parameters of kidney’s function, markers enzymes activity, was carried out morphological researches.

It was concluded that sodium pyrophosphate’s therapy reduce experimental oxalate nephrolithiasis.
Pharmacological activity of composition on the base of dihydroquercertin and lipoic acid
Authors: Ivanov I. S. , Sidekhmenova A. V. , Anischenko A. M. , Aliyev O. I. , Tyukavkina N. A. , Plotnikov M. B.
Published: June 2020

The purpose of this investigation is to the estimate influence of composition dihydroquercertin and lipoic acid on lymphatic flow, capillary filtration and blood viscosity in comparison with effects of individual components. Lymphokinetic activity of dihydroquercertin was detected. Capillary-protective effect, but in less degree lymphokinetic and hemorheologic ones of composition are higher than the effect of its separate components.
T-regulatory cells subpopulation in bronchial asthma and heterogeneous phenotypes of chronic obstructive pulmonary disease
Authors: Kirillova N. A. , Deyev I. A. , Kremer Ye. E. , Ogorodova L. M. , Chernogoryuk G. E.
Published: June 2020

Aim of the study was to investigate the levels of individual subpopulations of T-regulatory (T-reg) cells in patients with different phenotypes of chronic obstructive pulmonary disease (COPD) with moderate bronchial asthma and healthy volunteers. COPD was associated with increased level of natural (CD4+CD25high) T-cells, while emphysematous phenotype of disease was associated with the highest pool of natural CD4+CD25high. Bronchial asthma was associated with low levels of inducible (CD4+ FoxP3+ ) T-reg.
Matrix metalloproteinase system in blood serum in patients with squamous cell head and neck carcinomas
Authors: Klisho Ye. V. , Kondakova I. V. , Choynzonov Ye. L. , Cheremisina O. V. , Shishkin D. A.
Published: June 2020

The concentrations of matrix metalloproteinases (MMP-2, -3, -9) and their tissue inhibitors (TIMP-1, -2) were studied in blood serum of 193 patients with squamous cell head and neck carcinoma (SCHNC) and in 38 healthy donors using immunoenzymatic assay. The decreased MMP-3 and TIMP-1, -2 levels were found in patients with oral cavity tumors as compared to patients with laryngeal cancer. The serum MMP-9 and TIMP-1 levels were significantly higher in head and neck cancer patients than in healthy subjects. High TIMP-1 and MMP-9 levels in blood serum of patients with SCHNC should be greatly attended for detection of their predictive and prognostic significances.
The system of tumor necrosis factor α in the pathogenesis of autoimmune diabetes mellitus
Authors: Prokhorenko T. S. , Saprina T. V. , Lazarenko F. E. , Ryazantseva N. V. , Vorozhtsova I. N. , Novitsky V. V.
Published: June 2020

The aim of this study was to evaluate the impact of TNFα and their receptor in autoimmune diabetes. It was found the most pronounced inhibition of production of soluble forms of the receptor for TNFα in the background of an increased number of lymphocytes bearing membrane-associated receptors for TNFα in patients with manifested variant of diabetes type 1, compared to patients with latent autoimmune diabetes of adults.
Liver injury under chronic viral hepatitis C against the background of opiomania: morphological characters
Authors: Beloborodova Ye. V. , Podgornova D. V. , Purlik I. L. , Beloborodova E. I. , Petrova L. A. , Volchanovskaya M. M. , Shkorlupa S. G. , Goncharova I. A. , Akbasheva O. Ye.
Published: June 2020

To ascertain the severity of opium-induced liver injury for chronic viral hepatitis C (HCV) patients with detection of morphological characters of hepatocyte impact by opiates.

Needle biopsy of liver and the light microscopy of biopsy material were made both for isolated HCV and HCV+opiomania patients.

Liver injury (hepatitis activity, fibrosis stage) for HCV patients against the background of opiomania does not differ from the case of isolated HCV. Use of alcohol by opium addicts even in very small doses (10—15 g per day) cause the development of significantly more severe liver injury. Fibrosis of central vein was found significantly more often for HCV against the background of opiomania.

Fibrosis of central vein is a differential-diagnostic criterion of being opiates as an etiological factor of liver injury. Opiates as an isolated toxic factor does not cause severe liver injury for HCV patients unlike the use of alcohol even in small doses.
Forecasting probability of multiorgans insufficiency syndrome development in patients with a peritonitis
Authors: Alekseyev D. V.
Published: June 2020

Investigation of the indices, characterizing a functional condition of the hemostasis in patients with peritonitis, to takes more reliable trend forecasting a development of the multiorgans insufficiency syndrome and unfavorable outcome of the disease, tran research of hemodynamic and autointoxication states.
EEG-predictor’s effectiveness of starting therapy in epilepsy de novo by adult
Authors: Grebenyuk O. V. , Svetlic M. V. , Alifirova V. M. , Jankova V. I.
Published: June 2020

The study cerebral rhythm reactivity by functional load at 49 patient’s with epilepsy de novo. Make photic stimulation and cognitive activation. It was demonstrated that patients, who get remission on starting anticonvulsant therapy have intact brain reactivity.
The value of electroencephalography in the diagnosis and prognosis of the likely outcomes hypoxic-ischemic brain lesions in term neonates
Authors: Krivtsova L. A. , Belsky V. V.
Published: June 2020

In practice it’s often observed the discrepancy between clinical presentation of cerebral lesions in neonates and results of instrumental studies (neurosonography and computer tomography). The aim of the research was to explore the possibilities of the method of EEG for diagnosis and prognosis of cerebral lesions in neonates. The study was carried out in the design of Longitudinal prospective cohort controlled comparative non-randomized study with a simple glare. The study results demonstrate a great diagnostic and prognostic value of the method of EEG in detecting cerebral ischemia in neonates.
Walking disturbances at the Parkinsonism. New possibilities in the diagnosis, treatment and neyroprotection
Authors: Pokhabov D. V. , Abramov V. G. , Nesterova Yu. V.
Published: June 2020

The purpose of the study — to evaluate the effectiveness of the method tempo-rhythmic correction (TRC) distance in patients with Parkinson's disease (PD). We have used the device to determine step-speed performance rights, method TRC of walking, a questionnaire of quality of life of patients with PD (PDQ-39). Revealed that the method of TRC can improve walking in patients with Parkinson's disease, improve their life quality and reduce the pharmacoeconomic cost of treatment. Also, we have suggested a neuroprotective effect of the method of TRC.
Neurodynamic speech impairment in poststroke patients: pathogenesis, clinics, diagnostics
Authors: Prokopenko S. V. , Mozheyko Ye. Yu. , Vizel T. G. , Nikolskaya O. N.
Published: June 2020

The results of study, which devoted by diagnostics of neurodynamic speech disorders on the basis of clinical and computed speech transforming finding were shown. 186 patients in the poststroke period were examined. The possibility of using the method of computed transformation of time parameters of speech for objective registration of speech defeat and establishment of diagnosis of aphasia were revealed.
The factors of risk elongation of neck of uterus and genital prolapsed
Authors: Kokh L. I. , Dorosh T. N. , Balakshina N. G. , Tardaskina A. V.
Published: June 2020

We studied importance the factors of risk for elongation of neck of uterus, incomplete and complete prolapsus of internal female genital organs. In distinguish groups reliable important: connective tissue dysplasia with pathological level of urine oxyproline, childbirth, traumatic childbirth, manipulations on the neck of uterus.
Importance of standards of diagnosis and treatment for optimization of medical care quality to patients with dorsopathies
Authors: Peregontseva N. V. , Dekhnich S. N. , Khamtsova Ye. I.
Published: June 2020

The results of the research covering a problem of application of medical standards in diagnostics and treatment of patients suffering dorsopathies are presented. Its results have shown laws between various approaches by efficiency to conducting patients, duration of hospitalization and duration of time loss of invalidity.
Clinical immunological characteristic of patients with tick-borne encephalitis during the sharp period in Tomsk Region
Authors: Udintseva I. N. , Zhukova N. G. , Chechina O. Ye. , Poponina A. M. , Poltoratskaya T. N. , Shikhin A. V. , Pankina T. M. , Zima A. P. , Pinegina T. S.
Published: June 2020

Results of complex research of features of clinical and immunological profiles tick-borne encephalitis during the sharp period in Tomsk Region are resulted in the article. Last years redistribution of a parity of clinical displays of the sharp period in favor of prevalence of feverish forms of disease and a tendency to increase in cases of long circulation of an antigene of a virus tick-borne encephalitis is marked. One of the important reasons of such effect is decrease in immunological reactance of an organism with development of cytokine’s disbalance and expression infringement receptors of cytokines with lymphocytic cages.
Objectivic estimation metods of life quality at the patients with malignant brain glioma in dynamics of their complex treatment
Authors: Balayzin I. V. , Safonova I. A.
Published: June 2020

The purpose of the present research lies in objectivism estimation of life quality at the patients with malignant brain glioma in dynamics of their complex treatment. Patient's life quality was estimated both on Karnovsky scale and computer stabilometry, which was investigated before each course of chemotherapy. Computer stabilometry possesses of high sensitivity for registration of statokinetic infringements and allows estimating evenly the life quality of neurooncologic patients along with its subjective registration on Karnovsky scale.
Influence of polymorphic loci rs1800629 (TNFa), rs6074022 (CD40), rs187238 (IL-18), rs10492972 (KIF1B), rs4149584 (TNFRSF1A) on clinical features of multiple sclerosis subject to sex belonging in Russian ethnic group
Authors: Khanokh Ye. V. , Rozhdestvensky A. S. , Kudryavtseva Ye. A. , Kakulya A. V. , Delov R. A. , Filipenko M. A.
Published: June 2020

To study influence of polymorphic loci rs1800629 (TNFa), rs6074022 (CD40), rs187238 (IL-18), rs10492972 (KIF1B), rs4149584 (TNFRSF1A) on clinical features of multiple sclerosis (MS) subject to sex belonging in Omsk city and Omsk region. Methods: neurological examination, molecular-genetic, statistic analyses. 265 patients with multiple sclerosis and 576 healthy controls was observed. Results: observable polymorphic loci don’t associated with sex. In group of men dysfunction of the pyramidal, visual, pelvic functions on course of MS, in women group — dysfunction of the pyramidal functions, duration of the disease, height, CD40 genotipe.
Special features of care of stroke patients in a closed territorial formation on hospital period
Authors: Alifirova V. M. , Kabanova Ye. V. , Antukhova O. M. , Brazovskaya N. G.
Published: June 2020

1168 cases of acute stroke were investigated with the method of Hospital Stroke Register. Computer-based tomography was performed in 93,9% cases, autopsy — in 2,4% cases. Ischemic stroke prevailed in all the age groups. Mortality rate was 25,5%, 24% stroke patients are needed in help.