bluuebunny/crossref_metadata_2025 huggingface dataset:
Poor Prestroke Glycemic Control Increases the Rate of Symptomatic Intracranial Hemorrhage after Mechanical Thrombectomy
Authors: Luchowski Piotr , Szmygin Maciej , Barton Elzbieta , Prus Katarzyna , Szmygin Hanna , Pyra Krzysztof , Ficek Remigiusz , Rejdak Konrad
Published: February 2024

(1) Background: Diabetes is a well-established risk factor for acute ischemic stroke (AIS). This study evaluated the impact of prestroke glycemic control in diabetic patients on their 3-month clinical outcome after mechanical thrombectomy (MT). (2) Methods: AIS patients with a premorbid modified Rankin scale (mRS) score of 0–2 who were admitted within 6 h after stroke onset and treated with MT between January 2020 and August 2023 were retrospectively analyzed. The study evaluated the effect of prestroke glycemic control on the stroke severity, reperfusion rate, symptomatic intracranial hemorrhage (sICH) and favorable clinical outcome (modified Rankin scale score 0–2) at 3 months after endovascular treatment. (3) Results: A total of 364 patients were analyzed, with 275 cases of non-diabetes (ND), 66 of well-controlled diabetes (WCD) and 23 of poorly controlled diabetes (PCD). There was no significant difference in the baseline neurological deficit expressed according to the National Institutes of Health Stroke Scale among the three groups. The time from stroke onset to groin puncture was similar in the ND, WCD and PCD groups (median 215 min, 194.5 min and 222.5 min, respectively). There was no significant difference in the favorable 3-month clinical outcomes among these three groups (35.2% of ND patients, 42.4% of WCD patients and 39.1% of PCD patients) or full recovery (12.4% of ND patients, 11.0% of WCD patients and 17.4% of PCD patients). The rate of sICH was significantly higher in the PCD group as compared to the ND and WDP groups (21.7% of PCD patients versus 7.6% of ND patients, p = 0.038, and 6.0% of WCD patients, p = 0.046), but the 3-month mortality did not differ between the three groups (21.8% of ND group, 19.7% of WCD group and 26.1% of PCD group). (4) Conclusions: This study shows that poor prestroke glycemic control in AIS diabetic patients does not change the chance of a good clinical functional outcome after endovascular treatment. However, the increased risk of hemorrhagic complications in this group of patients should be considered.
CMR Predictors of Favorable Outcome in Myocarditis: A Single-Center Experience
Authors: Baritussio Anna , Cheng Chun-Yan , Simeti Giuseppe , Ocagli Honoria , Lorenzoni Giulia , Giordani Andrea Silvio , Basso Cristina , Rizzo Stefania , De Gaspari Monica , Motta Raffaella , De Conti Giorgio , Perazzolo Marra Martina , Tarantini Giuseppe , Iliceto Sabino , Gregori Dario , Marcolongo Renzo , Caforio Alida Linda Patrizia
Published: February 2024

Background: Cardiovascular magnetic resonance (CMR) has emerged as the most accurate, non-invasive method to support the diagnosis of clinically suspected myocarditis and as a risk-stratification tool in patients with cardiomyopathies. We aim to assess the diagnostic and prognostic role of CMR at diagnosis in patients with myocarditis. Methods: We enrolled consecutive single-center patients with 2013 ESC consensus-based endomyocardial biopsy (EMB)-proven or clinically suspected myocarditis undergoing CMR at diagnosis. The pre-specified outcome was defined as NYHA class > I and echocardiographic left ventricular ejection fraction (LVEF) < 50% at follow-up. Results: We included 207 patients (74% male, median age 36 years; 25% EMB-proven). CMR showed the highest sensitivity in myocarditis with infarct-like presentation. Patients with EMB-proven myocarditis were more likely to have diffuse LGE and right ventricular LGE (p < 0.001), which was also more common among patients with arrhythmic presentation (p = 0.001). The outcome was met in 17 patients at any follow-up time point, more commonly in those with larger biventricular volumes (p < 0.001), CMR-based diagnosis of dilated cardiomyopathy (p < 0.001), and ischemic LGE (p = 0.005). Higher biventricular systolic function (p < 0.001) and greater LGE extent (p = 0.033) at diagnosis had a protective effect. Conclusions: In our single-center cohort of rigorously defined myocarditis patients, higher biventricular systolic function and greater LGE extent on CMR at diagnosis identified patients with better functional class and higher left ventricular ejection fraction at follow-up. Conversely, larger biventricular volumes, CMR-based DCM features, and the presence of an ischemic LGE pattern at diagnosis were predictors of worse functional class and LV systolic dysfunction at follow-up. Larger prospective studies are warranted to extend our findings to multi-center cohorts.
Patient-Reported Outcomes of Maxillomandibular Surgery for Obstructive Sleep Apnea Treatment: A Scoping Review
Authors: Francisco Inês , Nunes Catarina , Baptista Paula Anabela , Marques Filipa , Prata Ribeiro Madalena , McEvoy Mariana , Santos Mariana , Oliveira Catarina , Marto Carlos Miguel , Spagnuolo Gianrico , Carrilho Eunice , Travassos Raquel , Vale Francisco
Published: February 2024

(1) Background: The present scoping review aims to scrutinize all existing patient-reported outcomes and assess the perspectives of obstructive sleep apnea patients after maxillomandibular surgery. (2) Methods: The review was carried out according to the extensions for scoping reviews using the PRISMA-ScR guidelines. Several databases were used to carry out the initial search. This study included randomized controlled trials, cohort studies, cross-sectional and case-control studies. The included studies considered patients with obstructive sleep apnea who were submitted to orthognathic surgery as the main subjects, and the patient’s perception of quality of life, satisfaction, treatment experience and side effects were assessed. (3) Results: From 1407 examined articles, a total of 16 were included. Most of the included studies used more than one questionnaire to assess quality of life, except for five articles. The most commonly referred instruments were the Epworth Sleepiness Scale, SF-36, the Functional Outcomes of Sleep and Ottawa Sleep Apnea. The most commonly assessed outcomes were sleep quality, daytime function, facial aesthetics, dental function and emotional health. (4) Conclusions: The number of variables that can be evaluated from a patient’s perspective are endless, as are the tools available to assess them. Not all of these tools, which are generally questionnaires, assess all the various outcomes, and some do not compare the pre- and post-surgical situations. Most of them are generic and lack specificity for obstructive sleep apnea.
Polycarbonate-Based Copolymer Micelles as Biodegradable Carriers of Anticancer Podophyllotoxin or Juniper Extracts
Authors: Kalinova Radostina G. , Dimitrov Ivaylo V. , Ivanova Diana I. , Ilieva Yana E. , Tashev Alexander N. , Zaharieva Maya M. , Angelov George , Najdenski Hristo M.
Published: February 2024

Podophyllotoxin (PPT) is used in the industrial production of efficient anticancer, antiviral and other drugs. Sinopodophyllum hexandrum or Podophyllum peltatum are natural sources of PPT, but at present they are considered as endangered species. Their PPT content is variable, depending on the growing conditions. Searching for new sources of PPT, some representatives of the genus Juniperus were found to exhibit efficient PPT biosynthesis. However, PPT is highly toxic and poorly soluble in water compound, which limits its clinical applications. In this connection, amphiphilic polymer micelles are considered to be suitable PPT carriers, aimed at increase in water solubility and decrease in toxicity. The present research deals with the evaluation of MPEG–polycarbonate block copolymer micelles loaded with PPT or juniper extracts. The active component-loaded polymer nanocarriers were characterized by dynamic and electrophoretic light scattering, as well as by transmission electron microscopy. The active component loading efficiency and loading capacity were also determined. Highly efficient antiproliferative activity of the loaded micelles was determined in a panel of cancer cell lines. The obtained amphiphilic nanocarriers, loaded with PPT-containing bioactive components, have application in future in vivo preclinical trials of their pharmacokinetics and pharmacodynamics as potential therapeutical agents in the prospective nanomedicine.
Active and Passive Mineralization of Bio-Gide® Membranes in Rat Calvaria Defects
Authors: Apaza Alccayhuaman Karol Ali , Heimel Patrick , Tangl Stefan , Lettner Stefan , Kampleitner Carina , Panahipour Layla , Kuchler Ulrike , Gruber Reinhard
Published: February 2024

Bio-Gide® is a collagen membrane routinely used in guided bone regeneration. Recent studies have shown that this collagen membrane has osteoconductive properties, meaning that it can support the growth of new bone. However, it has also been observed that the collagen membrane has areas of mineralized fibers which can occur spontaneously and independently of osteoblasts. To better understand how this works, we established a model using minced collagen membranes to reduce the active mineralization of intact collagen membranes in favor of passive mineralization. We thus compared the original intact membrane with a minced collagen membrane in a 5 mm calvarial defect model in Sprague Dawley rats. After three weeks of healing, histology and microcomputed tomography (μCT) were performed. Histological analysis confirmed the osteoconductive properties, with new bone growing inside the intact collagen membrane. However, in minced collagen membranes, the osteoconductive properties were restricted to the defect margins. Interestingly, histology revealed large mineralized areas indicating passive mineralization with no signs of bone formation. In the μCT analysis, the intact collagen membranes caused a higher median mineralized volume (1.5 mm3) compared with the minced group (0.4 mm3), but this lacked significance (p = 0.09). The μCT analysis needs to be interpreted carefully, particularly in defects filled with minced membranes, considering that the mineralized tissue may not necessarily be bone but also the result of passive mineralization. Taken together, the findings suggest that Bio-Gide® collagen membranes support bone formation while also exhibiting potential for passive mineralization.
Development of a Powder Analysis Procedure Based on Imaging Techniques for Examining Aggregation and Segregation Phenomena
Authors: Bonifazi Giuseppe , Barontini Paolo , Gasbarrone Riccardo , Gattabria Davide , Serranti Silvia
Published: February 2024

In this manuscript, a method that utilizes classical image techniques to assess particle aggregation and segregation, with the primary goal of validating particle size distribution determined by conventional methods, is presented. This approach can represent a supplementary tool in quality control systems for powder production processes in industries such as manufacturing and pharmaceuticals. The methodology involves the acquisition of high-resolution images, followed by their fractal and textural analysis. Fractal analysis plays a crucial role by quantitatively measuring the complexity and self-similarity of particle structures. This approach allows for the numerical evaluation of aggregation and segregation phenomena, providing valuable insights into the underlying mechanisms at play. Textural analysis contributes to the characterization of patterns and spatial correlations observed in particle images. The examination of textural features offers an additional understanding of particle arrangement and organization. Consequently, it aids in validating the accuracy of particle size distribution measurements. To this end, by incorporating fractal and structural analysis, a methodology that enhances the reliability and accuracy of particle size distribution validation is obtained. It enables the identification of irregularities, anomalies, and subtle variations in particle arrangements that might not be detected by traditional measurement techniques alone.
The Effect of Mindfulness on the Promotion of Graduate Students’ Scientific Research Creativity: The Chain Mediating Role of Flow Experience and Creative Self-Efficacy
Authors: Yao Hao , Fan Yabing , Duan Shifei
Published: February 2024

Creativity is a universal core higher-order cognitive ability in the 21st century, which reflects a country’s core competitiveness and soft power. Mindfulness, as an important concept in positive psychology, has also received attention for its potential effect on research creativity. Using structural equation modeling and bootstrap methods, this study investigated the relationship between mindfulness and research creativity among 1210 Chinese graduate students. Additionally, we explored the mediating effect of flow experience and creative self-efficacy in this relationship. The research results showed that mindfulness had a direct positive effect on graduate students’ scientific research creativity. The mediating effect of flow experience and creative self-efficacy, as well as the chain mediating effect, were established, with the mediating ratio being 13.1% and 30.0%, respectively, and the indirect effect of chain mediating accounting for 34.1%. Interestingly, the effect mechanism at the gender level was various, with the mediating effect of mindfulness on scientific research creativity being higher among male graduate students. The results of this study revealed the mechanism of mindfulness on graduate students’ scientific research creativity, offering valuable insights for enhancing their creative capabilities in the realm of scientific research.
Reducing the Cost of 3D Metal Printing Using Selective Laser Melting (SLM) Technology in the Manufacture of a Drill Body by Reinforcing Thin-Walled Shell Forms with Metal-Polymers
Authors: Lubimyi Nickolay S. , Chepchurov Mihail , Polshin Andrey A. , Gerasimov Michael D. , Chetverikov Boris S. , Chetverikova Anastasia , Tikhonov Alexander A. , Maltsev Ardalion
Published: February 2024

This article describes the technology for manufacturing a metal composite structure of a metal-cutting tool body. The main problem with using metal 3D-printing is its prohibitively high cost. The initial data for carrying out finite element calculations are presented, in particular, the calculation and justification of the selected loads on the drill body arising from metal-cutting forces. The described methodology for designing a digital model of a metal-cutting tool for the purpose of its further production using SLM 3D metal printing methods facilitates the procurement of a digital model characterized by a reduced weight and volume of material. The described design technology involves the production of a thin-walled outer shell that forms the external technological surfaces necessary for the drill body, as well as internal structural elements formed as a result of topological optimization of the product shape. Much attention in this article is paid to the description of the technology for filling internal cavities with a viscous metal polymer, formed as a result of the topological optimization of the original model. Due to this design approach, it is possible to reduce the volume of 3D metal printing by 32%, which amounts to more than USD 135 in value terms.
White Rot Fungi as Tools for the Bioremediation of Xenobiotics: A Review
Authors: Torres-Farradá Giselle , Thijs Sofie , Rineau Francois , Guerra Gilda , Vangronsveld Jaco
Published: February 2024

Industrial development has enhanced the release into the environment of large quantities of chemical compounds with high toxicity and limited prospects of degradation. The pollution of soil and water with xenobiotic chemicals has become a major ecological issue; therefore, innovative treatment technologies need to be explored. Fungal bioremediation is a promising technology exploiting their metabolic potential to remove or lower the concentrations of xenobiotics. In particular, white rot fungi (WRF) are unique microorganisms that show high capacities to degrade a wide range of toxic xenobiotic compounds such as synthetic dyes, chlorophenols, polychlorinated biphenyls, organophosphate pesticides, explosives and polycyclic aromatic hydrocarbons (PAHs). In this review, we address the main classes of enzymes involved in the fungal degradation of organic pollutants, the main mechanisms used by fungi to degrade these chemicals and the suitability of fungal biomass or extracellular enzymes for bioremediation. We also exemplify the role of several fungi in degrading pollutants such as synthetic dyes, PAHs and emerging pollutants such as pharmaceuticals and perfluoroalkyl/polyfluoroalkyl substances (PFASs). Finally, we discuss the existing current limitations of using WRF for the bioremediation of polluted environments and future strategies to improve biodegradation processes.
Iatrogenic Cerebrospinal Fluid Leak in Endoscopic Sinus Surgery: Topographical Map and Influence of Skull Base Asymmetry
Authors: Vinciguerra Alessandro , Dohin Isabelle , Daloiso Antonio , Boaria Francesco , Marc Morgane , Verillaud Benjamin , Chatelet Florian , Herman Philippe
Published: February 2024

Background: Iatrogenic cerebrospinal fluid leak (iCSF-L) is a major complication of endonasal surgeries whose occurrence is always a potential adverse event due to anatomical variation/asymmetry of the skull base (SB). The aim of this manuscript is to provide a topographical map of iCSF-L and to investigate the role of SB asymmetry in iCSF-L occurrence. Methods: In this retrospective study, the location of iCSF-L dural defect was studied and compared to patients affected by spontaneous and post-traumatic CSF-L. Considering only iCSF-L, after having collected the SB asymmetry data, the Keros, Gera, distance of the anterior ethmoidal artery from the SB, frontal sinus pneumatization, and Thailand–Malaysia–Singapore score classifications were compared to a control group of patients. Results: A total of 153 CSF-Ls (103 spontaneous, 37 iatrogenic, and 13 traumatic) were included. A significant association was noted (p < 0.001) between the nature of the CSF-L and the areas involved. Considering iCSF-Ls, only the Gera classification was significantly different (p < 0.05) and the most reliable in predicting the risk of dural transgression (AUC = 0.719). Conclusions: ICSF-Ls present peculiar regional SB involvement with the cribriform plate, with the ethmoidal roof being the most involved. After having assessed the asymmetry of the SB, the Gera classification was the most reliable one.
Association between Gout and Gastric Cancer: A Nested Case–Control Study Using a National Health Sample Cohort
Authors: Kwon Mi Jung , Han Kyeong Min , Kim Ji Hee , Kim Joo-Hee , Kim Min-Jeong , Kim Nan Young , Choi Hyo Geun , Kang Ho Suk
Published: February 2024

Given the global significance of gout and gastric cancer (GC) as major health problems with interrelated impacts, we examined the development of GC in Korean patients with gout. We conducted a nested case–control study using data from 10,174 GC patients and 40,696 control patients from the Korean National Health Insurance Service-National Sample Cohort database. Propensity score matching (1:4) with propensity score overlap-weighted adjustment was used to reduce selection bias and estimate the odds ratio (OR) and 95% confidence intervals (CIs) for the association between gout and GC. An adjusted OR for GC was not significantly higher in patients with gout than in control patients (1.02; 95% CI, 0.93–1.12; p = 0.652). Additionally, no association between gout and GC was observed in subgroup analyses such as sex, age, level of income, region of residence, or Charlson Comorbidity Index score. In conclusion, these results suggest that gout is not a significant independent risk factor for GC among the Korean population. Additional investigation is required to establish a causal association between gout and GC, and to generalize these results to general populations.
Transglutaminase2: An Enduring Enzyme in Diabetes and Age-Related Metabolic Diseases
Authors: Yadav Neera , Kim Sun-Yeou
Published: February 2024

Tissue transglutaminase2 (TG2) has emerged as a key enigmatic protein in the development of various metabolic and age-related diseases. It catalyzes covalent cross-linking of countless proteins and provides strength to the extracellular matrix and resistance to proteolytic degradation via different pathways, including NF-kβ, TGF-β and PI3K/Akt as the major signaling pathways. The etiology of diabetes and associated diseases has been found to be linked to unbalanced TG2 activity that may not only result in impaired or delayed wound healing in diabetics but also worsen degenerative and metabolic disease conditions. TG2 is usually overexpressed in diabetes, fibrosis, cancer, and neurodegenerative disorders. These TG2-linked diseases are usually associated with prolonged activation of inflammatory pathways. Therefore, reducing the inflammatory mechanisms and improving tissue remodeling appear to be the main treatment strategies to exterminate TG2-linked diseases. The present review aims to deliver a detailed overview of the existing understanding of TG2 in diabetes and associated diseases’ progression, as well as treatment strategies to regulate TG2 tightly and its potential clinical applications. Our research endorses the notion that TG2 can serve as an effective early-stage diagnostic biomarker for metabolic diseases and a therapeutic target for the development of potential drug.
Web Mining of Online Resources for German Labor Market Research and Education: Finding the Ground Truth?
Authors: Fischer Andreas , Dörpinghaus Jens
Published: February 2024

The labor market is highly dependent on vocational and academic education, training, retraining, and further education in order to master challenges such as advancing digitalization and sustainability. Further training is a key factor in ensuring a qualified workforce, the employability of all employees, and, thus, national competitiveness and innovation. In the contribution at hand, we explore an innovative way to derive knowledge about learning pathways by connecting the dots from different data sources of the German labor market. In particular, we focus on the web mining of online resources for German labor market research and education, such as online advertisements, information portals, and official government websites. A key question for working with different data sources is how to find the ground truth and common data structures that can be used to make the data interoperable. We discuss how to classify and summarize web data from different platforms and which methods can be used for extracting data, entities and relationships from online resources on the German labor market to build a network of educational pathways. Our proposed solution is based on the classification of occupations (KldB) and related document codes (DKZ), and combines natural language processing and knowledge graph technologies. Our research provides the foundation for further investigation into educational pathways and linked data for labor market research. While our work focuses on German data, it is also useful for other German-speaking countries and could easily be extended to other languages such as English.
Integration of Climate Change Strategies into Policy and Planning for Regional Development: A Case Study of Greece
Authors: Kalogiannidis Stavros , Kalfas Dimitrios , Papaevangelou Olympia , Chatzitheodoridis Fotios , Katsetsiadou Katerina-Navsika , Lekkas Efthymios
Published: February 2024

Climate change presents a pressing challenge to regional development, impacting economies, environments, and societies across the globe. Europe, with its diverse regions and commitment to sustainability, serves as a unique case study for exploring the integration of climate change strategies into regional policy and planning. The purpose of this study is to analyze the integration of climate change strategies into policy and planning for regional development in Europe, especially in Greece. Data was collected from 270 environmental experts across Greece using a questionnaire. The results highlight the significance of regional economic growth (gross regional product), infrastructure quality, educational attainment, and a conducive business environment as key measures of regional development. Opportunities arising from climate change strategy integration are explored, revealing economic benefits, environmental opportunities, social enhancements, and technological advancements. These opportunities not only mitigate climate change’s adverse impacts but also foster innovation, economic growth, and community resilience. Successful integration can position regions as global leaders in sustainability and innovation. Correlation and regression analyses reveal that opportunities for integration and common climate change strategies positively influence regional development, while barriers exhibit a counterintuitive positive relationship. However, several barriers hinder integration efforts, including institutional fragmentation, resource constraints, conflicting political and economic priorities, and insufficient stakeholder engagement. This study sheds light on the intricate relationship between climate change, policy integration, and regional development in Greece. It supports the potential for regions to drive sustainability and innovation while navigating the challenges of climate change, ultimately contributing to a more resilient and prosperous future.
Identifying Land Use Functions in Five New First-Tier Cities Based on Multi-Source Big Data
Authors: Yang Wangmin , Ye Yang , Fan Bowei , Liu Shuang , Xu Jingwen
Published: February 2024

With the continuous development of big data technology, semantic-rich multi-source big data provides broader prospects for the research of urban land use function recognition. This study relied on POI data and OSM data to select the central urban areas of five new first-tier cities as the study areas. The TF-IDF algorithm was used to identify the land use functional layout of the study area and establish a confusion matrix for accuracy verification. The results show that: (1) The common feature of these five cities is that the total number and area of land parcels for residential land, commercial service land, public management and service land, and green space and open space land all account for over 90%. (2) The Kappa coefficients were all in the range [0.61, 0.80], indicating a high consistency of accuracy evaluation. (3) Chengdu and Tianjin have the highest land use function mixing degree, followed by Xi‘an, Nanjing, and Hangzhou. (4) Among the five new first-tier cities, Hangzhou and Nanjing have the highest similarity in land use function structure layout. This study attempts to reveal the current land use situation of five cities, which will provide a reference for urban development planning and management.
Stem Cells and Bone Tissue Engineering
Authors: Gao Xueqin , Ruzbarsky Joseph J. , Layne Jonathan E. , Xiao Xiang , Huard Johnny
Published: February 2024

Segmental bone defects that are caused by trauma, infection, tumor resection, or osteoporotic fractures present significant surgical treatment challenges. Host bone autograft is considered the gold standard for restoring function but comes with the cost of harvest site comorbidity. Allograft bone is a secondary option but has its own limitations in the incorporation with the host bone as well as its cost. Therefore, developing new bone tissue engineering strategies to treat bone defects is critically needed. In the past three decades, the use of stem cells that are delivered with different scaffolds or growth factors for bone tissue engineering has made tremendous progress. Many varieties of stem cells have been isolated from different tissues for use in bone tissue engineering. This review summarizes the progress in using different postnatal stem cells, including bone marrow mesenchymal stem cells, muscle-derived stem cells, adipose-derived stem cells, dental pulp stem cells/periodontal ligament stem cells, periosteum stem cells, umbilical cord-derived stem cells, peripheral blood stem cells, urine-derived stem cells, stem cells from apical papilla, and induced pluripotent stem cells, for bone tissue engineering and repair. This review also summarizes the progress using exosomes or extracellular vesicles that are delivered with various scaffolds for bone repair. The advantages and disadvantages of each type of stem cell are also discussed and explained in detail. It is hoped that in the future, these preclinical results will translate into new regenerative therapies for bone defect repair.
The GARD Prebiotic Reproduction Model Described in Order and Complexity
Authors: Mayer Christian , Lancet Doron , Markovitch Omer
Published: February 2024

Early steps in the origin of life were necessarily connected to the unlikely formation of self-reproducing structures from chaotic chemistry. Simulations of chemical kinetics based on the graded autocatalysis replication domain (GARD) model demonstrate the ability of a micellar system to become self-reproducing units away from equilibrium. Even though they may be very rare in the initial state of the system, the property of their endogenous mutually catalytic networks being dynamic attractors greatly enhanced reproduction propensity, revealing their potential for selection and Darwinian evolution processes. In parallel, order and complexity have been shown to be crucial parameters in successful evolution. Here, we probe these parameters in the dynamics of GARD-governed entities in an attempt to identify characteristic mechanisms of their development in non-covalent molecular assemblies. Using a virtual random walk perspective, a value for consecutive order is defined based on statistical thermodynamics. The complexity, on the other hand, is determined by the size of a minimal algorithm fully describing the statistical properties of the random walk. By referring to a previously published diagonal line in an order/complexity diagram that represents the progression of evolution, it is shown that the GARD model has the potential to advance in this direction. These results can serve as a solid foundation for identifying general criteria for future analyses of evolving systems.
Minimally Invasive Surgery in Liver Transplantation: From Living Liver Donation to Graft Implantation
Authors: Avramidou Eleni , Terlemes Konstantinos , Lymperopoulou Afroditi , Katsanos Georgios , Antoniadis Nikolaos , Kofinas Athanasios , Vasileiadou Stella , Karakasi Konstantina-Eleni , Tsoulfas Georgios
Published: February 2024

Since the end of the 20th century and the establishment of minimally invasive techniques, they have become the preferred operative method by many surgeons. These techniques were applied to liver surgery for the first time in 1991, while as far as transplantation is concerned their application was limited to the living donor procedure. We performed a review of the literature by searching in Pubmed and Scopus using the following keywords: Liver transplantation, Minimally invasive surgery(MIS) living liver donor surgery. Applications of MIS are recorded in surgeries involving the donor and the recipient. Regarding the recipient surgeries, the reports are limited to 25 patients, including combinations of laparoscopic, robotic and open techniques, while in the living donor surgery, the reports are much more numerous and with larger series of patients. Shorter hospitalization times and less blood loss are recorded, especially in centers with experience in a large number of cases. Regarding the living donor surgery, MIS follows the same principles as a conventional hepatectomy and is already the method of choice in many specialized centers. Regarding the recipient surgery, significant questions arise mainly concerning the safe handling of the liver graft.
Stability Analysis of the Output Speed in a Hydraulic System Powered by an Inverter-Fed Motor
Authors: Geng Baolong , Jing Qian , Wang Jianji , Gu Lichen , Lian Xiao , Guo Jinchang
Published: February 2024

The stability of the output speed of a hydraulic system has a great influence on the working performance of hydraulic equipment. It changes with the system working conditions. The increase in leakage caused by the wear of the hydraulic kinematic pair and the slip of the motor lead to the instability of the output speed. Although the hydraulic system can satisfy the output requirements of the active control scheme with ex ante decision making or the passive feedback control strategy with ex post compensation, it also causes an increase in system complexity and manufacturing cost. The speed stiffness as a basic characteristic of the output of the hydraulic system has not been sufficiently investigated and evaluated. In this paper, the IFMDH (inverter-fed, motor-driven hydraulic) system is taken as the object, and the coupling relationship of each link of the system is revealed by mathematical modelling. The reliability of the model is verified under a wide range of speed and load variations in combination with experiments. By redefining the speed stiffness quantification method, the effects of load conditions, motor stiffness, and speed ratio at the output end on the speed stability of the system are discussed in conjunction with the system coupling mechanism model. The conclusions show that the motor stiffness and the addition of a speed reducer have a significant effect on the system speed stiffness, where changing the output speed ratio has a significant effect on the speed stiffness. The conclusions of the study provide technical support for the rapid design, selection, and system optimisation of hydraulic systems in common scenarios.
Analysis of Micro-Evolution Mechanism of 3D Crack Initiation in Brittle Materials with Hole under Uniaxial Compression
Authors: Maimaitiyusupu Semaierjiang , Zhu Zhende , Ren Xuhua , Zhang Hui , Zhu Shu
Published: February 2024

This article investigates the microscopic mechanism of crack initiation and propagation in three-dimensional embedded cracks in brittle materials containing circular holes. First, a method for the development of transparent, brittle materials is proposed. Second, UCS tests were conducted on transparent, brittle materials containing circular holes and internally embedded three-dimensional cracks. Finally, a numerical model was established in PFC3D to analyze the crack initiation and propagation mechanism. The results show that when α = 0° (α refers to the pre-existing crack inclination), the upper tip of the pre-existing crack appears as a tensile wing crack, and the lower tip of the pre-existing crack appears as a tensile–shear mixed crack. When α = 30°, no wing crack appears, and the tensile crack on the fracture surface only appears after the hole cracks. When α = 60 and 90°, a tensile wing crack and an anti-wing tensile–shear mixed crack appear at the upper tip of the pre-existing crack. A tensile wing crack appears at the lower tip of the pre-existing crack and appears “self-limiting”. During the propagation of wing cracks to the surface of the specimen, the transition sequence of the crack propagation mechanism is tensile through failure—tension-shear mixed failure—tensile failure. It can be seen that the interaction between the crack and hole has an important influence on the evolution mechanism of the crack and the failure mode of the specimen.
Effect of Porosity/Binder Index on Strength, Stiffness and Microstructure of Cemented Clay: The Impact of Sustainable Development Geomaterials
Authors: Baldovino Jair de Jesús Arrieta , Nuñez de la Rosa Yamid E. , Calabokis Oriana Palma
Published: February 2024

Searching for alternative material options to reduce the extraction of natural resources is essential for promoting a more sustainable world. This is especially relevant in construction and infrastructure projects, where significant volumes of materials are used. This paper aims to introduce three alternative materials, crushed ground glass (GG), recycled gypsum (GY) and crushed lime waste (CLW), byproducts of construction industry geomaterials, to enhance the mechanical properties of clay soil in Cartagena de Indias, Colombia. These materials show promise as cementitious and frictional agents, combined with soil and cement. Rigorous testing, including tests on unconfined compressive strength (qu) and initial stiffness (Go) and with a scanning electron microscope (SEM), reveals a correlation between strength, stiffness and the novel porosity/binder index (η/Civ) and provides mixed design equations for the novel geomaterials. Micro-level analyses show the formation of hydrated calcium silicates and complex interactions among the waste materials, cement and clay. These new geomaterials offer an eco-friendly alternative to traditional cementation, contributing to geotechnical solutions in vulnerable tropical regions.
Shrinkage Reduction in Nanopore-Rich Cement Paste Based on Facile Organic Modification of Montmorillonite
Authors: Yang Fengyuan , Yang Ying , Chen Shaoyou , Jin Chao , Jiang Jun , Liu Tie , Lv Fei , Yang Chenxi , Lu Zhongyuan , Li Jun
Published: February 2024

The organic modification of montmorillonite was successfully achieved using cetyltrimethyl ammonium bromide under facile conditions. The modified montmorillonite was subsequently used for the fabrication of montmorillonite-induced nanopore-rich cement paste (MNCP), and the shrinkage behavior and fundamental performance of MNCP were also investigated. The results indicate that alkali cations on a montmorillonite layer surface were exchanged by using CTAB under 80 °C, successfully achieving the organic modification of montmorillonite. As a pore-forming agent, the modified montmorillonite caused a reduction in shrinkage: the 28-day autogenous shrinkage at a design density of 400 kg/m3 and 800 kg/m3 was reduced to 2.05 mm/m and 0.24 mm/m, and the highest reduction percentages during the 28-day drying shrinkage were 68.1% and 62.2%, respectively. The enlarged interlamellar pores and hydrophobic effects caused by the organic modification of montmorillonite aided this process. Organic-modified montmorillonite had a minor influence on dry density and thermal conductivity and could contribute to an enhancement of strength in MNCP.
Preparation and Properties of Porous Concrete Based on Geopolymer of Red Mud and Yellow River Sediment
Authors: Lv Yajun , Chen Yiming , Dai Wei , Yang He , Jiang Linhua , Li Keliang , Jin Weizhun
Published: February 2024

Red mud (RM) and Yellow River sediment (YRS) are challenging to handle as waste materials. In this study, RM with geopolymer and heavy metal adsorption characteristics was combined with YRS and ground granulated blast furnace slag (GGBS) to develop a porous geopolymer with high strength and high adsorption performance. A geopolymer cementitious material with high strength was prepared using high temperature water bath curing of 90 °C and different dosages of YRS, and a porous geopolymer concrete was further prepared. The compressive strength, fluidity and setting time of geopolymer cementitious materials were tested, and the compressive strength, porosity and permeability of porous geopolymer concrete were also tested. The environmental impact assessment of geopolymer cementitious materials was further conducted. The hydration products and microstructure of geopolymer gel materials were analyzed by XRD, SEM and FT-IR tests. The results show that the addition of YRS can effectively prolong the setting time of the geopolymer cementitious material, and the enhancement rate is as high as 150% compared with the geopolymer cementitious materials without the addition of YRS. An appropriate amount of YRS can improve the compressive strength of the geopolymer cementitious materials, and its early compressive strength can be further improved under the high temperature water bath curing of 90 °C, and the compressive strength at an age of 3 d can be up to 86.7 MPa. Meanwhile, the compressive strength of porous geopolymer concrete at an age of 28 d is up to 28.1 MPa. YRS can participate in geopolymer reactions, and high temperature water bath curing can promote the reaction degree. Curing method and YRS dosages have little effect on the porosity and permeability of the porous geopolymer concrete. The porous geopolymer has a good heavy metal adsorption effect, and the alkaline pH values can be gradually diluted to neutral.
Cavity Swelling of 15-15Ti Steel at High Doses by Ion Irradiation
Authors: Liu Cong , Ma Hailiang , Fan Ping , Li Ke , Zhang Qiaoli , Du Aibing , Feng Wei , Su Xiping , Zhu Shengyun , Yuan Daqing
Published: February 2024

The titanium-stabilized austenitic stainless steel Fe-15Cr-15Ni, which shows enhanced resistance to irradiation swelling compared with more traditional 316Ti, has been selected as a core material for fast reactors. Data on the evolution of irradiation swelling in 15-15Ti steels at very high doses, which cannot be easily achieved by neutron irradiation, are still lacking. In this paper, the swelling behavior of the titanium-modified austenitic stainless steel 15-15Ti was investigated by pre-implantation of He at room temperature followed by Ni-ion irradiation at 580 °C to peak doses of 120, 240 and 400 dpa. Relatively small cavities were observed in the zone of helium implantation, while large cavities appeared in the region near the damage peak. A correction formula for the dpa curve was proposed and applied to samples with large swelling. It was found that the steady-state swelling rate of 15-15Ti remains at ~1%/dpa even at high doses. By comparing the swelling data of the helium-implanted and helium-free regions at same doses, 70 dpa and 122 dpa, the suppression of swelling by excessive helium can be deduced at such doses.
Structural Study of the Thermoelectric Work Units Encapsulated with Cement Paste for Building Energy Harvesting
Authors: Lai Ziqiang , Hao Yali , Wei Yongqi , She Anming , Yao Wu
Published: February 2024

Cement-based material encapsulation is a method of encapsulating electronic devices in highly thermally conductive cement-based materials to improve the heat dissipation performance of electronic components. In the field of construction, a thermoelectric generator (TEG) encapsulated with cement-based materials used in the building envelope has significant potential for waste heat energy recovery. The purpose of this study was to investigate the effect of cement-based materials integrated with aluminum heatsinks on the heat dissipation of the TEG composite structure. In this work, three types of thermoelectric work units encapsulated with cement paste were proposed. Moreover, we explored the effect of encapsulated structure, heat dissipation area, the height of thermoelectric single leg, and heat input temperature on maintaining the temperature difference between the two sides of the thermoelectric single leg with COMSOL Multiphysics. The numerical simulation results showed that under the conditions of a heat source temperature of 313.15 K and ambient temperature of 298.15 K, the temperature difference between the two sides of the internal thermoelectric single leg of Type-III can maintain a stable temperature difference of 7.77 K, which is 32.14% higher than that of Type-I and Type-II (5.88 K), and increased by 26.82% in the actual experiment. This work provides a reference for the selection and application of TEG composite structures of cement-based materials combined with aluminum heatsinks.
Resonant Tunnelling and Intersubband Optical Properties of ZnO/ZnMgO Semiconductor Heterostructures: Impact of Doping and Layer Structure Variation
Authors: Atić Aleksandar , Wang Xizhe , Vuković Nikola , Stanojević Novak , Demić Aleksandar , Indjin Dragan , Radovanović Jelena
Published: February 2024

ZnO-based heterostructures are up-and-coming candidates for terahertz (THz) optoelectronic devices, largely owing to their innate material attributes. The significant ZnO LO-phonon energy plays a pivotal role in mitigating thermally induced LO-phonon scattering, potentially significantly elevating the temperature performance of quantum cascade lasers (QCLs). In this work, we calculate the electronic structure and absorption of ZnO/ZnMgO multiple semiconductor quantum wells (MQWs) and the current density–voltage characteristics of nonpolar m-plane ZnO/ZnMgO double-barrier resonant tunnelling diodes (RTDs). Both MQWs and RTDs are considered here as two building blocks of a QCL. We show how the doping, Mg percentage and layer thickness affect the absorption of MQWs at room temperature. We confirm that in the high doping concentrations regime, a full quantum treatment that includes the depolarisation shift effect must be considered, as it shifts mid-infrared absorption peak energy for several tens of meV. Furthermore, we also focus on the performance of RTDs for various parameter changes and conclude that, to maximise the peak-to-valley ratio (PVR), the optimal doping density of the analysed ZnO/Zn88Mg12O double-barrier RTD should be approximately 1018 cm−3, whilst the optimal barrier thickness should be 1.3 nm, with a Mg mole fraction of ~9%.
Nitrogen Removal from Landfill Leachate Using Biochar Derived from Wheat Straw
Authors: Igwegbe Chinenye Adaobi , Kozłowski Michał , Wąsowicz Jagoda , Pęczek Edyta , Białowiec Andrzej
Published: February 2024

Landfill leachate (LLCH) disposal poses challenges due to high pollutant concentrations. This study investigates the use of biochar (BC) derived from wheat straw for nitrogen content reduction. Laboratory experiments evaluated BC’s adsorption capacity (qm) for nitrogen removal from ammonium chloride solution (NH4Cl) and LLCH, along with testing isotherm models. The results demonstrated that BC was more efficient (95.08%) than commercial activated carbon AC (93.11%), the blank, in adsorbing nitrogen from NH4Cl. This superior performance of BC may be attributed to its higher carbon content (57.74%) observed through elemental analysis. Lower results for BC/LLCH may be due to LLCH’s complex chemical matrix. The Langmuir isotherm model best described BC/NH4Cl adsorption (qm = 0.5738 mg/g). The AC/NH4Cl data also fitted into the Langmuir (R2 ˃ 0.9) with a qm of 0.9469 mg/g, and 26.667 mg/g (R2 ˂ 0.9) was obtained for BC/LLCH; the BC/LLCH also gave higher qm (R2 ˃ 0.9) using the Jovanovich model (which also follows Langmuir’s assumptions). The mean energy of the adsorption values estimated for the AC/NH4Cl, BC/NH4Cl, and BC/LLCH processes were 353.55, 353.55, and 223.61 kJ/mol, respectively, suggesting that they are all chemisorption processes and ion exchange influenced their adsorption processes. The Freundlich constant (1/n) value suggests average adsorption for BC/LLCH. The BC/LLCH data followed the Harkins–Jura model (R2: 0.9992), suggesting multilayered adsorption (or mesopore filling). In conclusion, biochar derived from wheat straw shows promising potential for landfill leachate remediation, offering efficient nitrogen removal capabilities and demonstrating compatibility with various adsorption models. This research also lays the groundwork for further exploration of other biochar-based materials in addressing environmental challenges associated with landfill leachate contamination.
The Superconductivity in Bi-Doped BaFe2As2 Single Crystals
Authors: Si Jiabin , Zhao Jianfa , Liu Ying , Liu Ying , Jin Changqing , Liu Jibing , Xing Lingyi
Published: February 2024

We have successfully synthesized a series of Bi-doped BaFe2As2 high-quality single crystals for the first time. X-ray diffraction (XRD) patterns show an expansion of lattice parameter c with Bi doping, indicating a negative pressure effect. By investigating the resistivity, a Fermi liquid (FL) to non-Fermi liquid (NFL) crossover is observed from normal state to antiferromagnetic order state, accompanied by three superconducting transitions labeled as SC I, SC II and SC III, which are supposed to be induced by three superconducting realms with various Bi concentrations. Thus, we propose that the NFL behavior is closely related to the presence of superconductivity. The magnetic susceptibility measurements further speculate that the SC I and SC III phases should exhibit filamentary superconductivity while the SC II exhibits a possible bulk superconductivity of TC~7 K.