bluuebunny/crossref_metadata_2025 huggingface dataset:
The effectiveness of advanced case management in community-based long-term care services
Authors: Ueng Ruey-Shiuan , Hu Hsiao-Yun , Huang Chao-Ming , Chang Yu-Ping , Hsu Chia-Chen
Published: October 2022

Aim: This study examined the long-term care in Taiwan to determine the effectiveness of advanced case management with Community Integrated Care Service.
Methods: This was a retrospective observational study targeting individuals who had developed disabilities and received services for at least 6 months between January 2018 and June 2021. Participants who received only long-term care services were assigned to the control group, and those who received advanced case management with long-term care were assigned to the experimental group.Analyzed disability prevention, depression improvement, and consumption of medical resources.
Results: The data of 1,947 participants. The ratios of complicated care needs and severe disabilities were significantly higher in the experimental group. The two groups had similar levels of disabilities. The experimental group had significantly of depression improvement scores than the control group did. No significant difference was observed in medical resources expended before and after intervention between groups. Complex cases had more medical expenses, and interventions prevent the medical expenses from increasing rapidly.
Conclusion: The advanced case management group achieved superior results in alleviating depression and lowering the costs incurred on the taxpayers and patients’ families . From a holistic health-care perspective, advanced case management is essential.
Controlled chemical transformation and crystallization design for the formation of multifunctional Cu-doped ZnO/ZnAl2O4 composites
Authors: Tinku Artyom , Shelemanov Andrey , Evstropiev Sergey , Nikonorov Nikolay , Dukelskii Konstantin
Published: October 2022

Photoactive Cu-doped ZnO-ZnAl2O4 ceramic nanocomposites and coatings were prepared by polymer-salt method. The luminescent and IR spectroscopy, SEM and XRD methods were used for the study the structure, morphology and materials properties. The nanocomposites consist of small hexagonal ZnO and cubic ZnAl2O4 nanocrystals having size about 10 nm. The study of luminescence properties shows that prepared nanocomposites can be used as light down-converters that transfer UV-C radiation into UV-A and visible spectral range. These nanocomposites can be very attractive in photovoltaic applications as spectral down-converters. Also obtained nanocomposites demonstrate the ability to generate chemically active singlet oxygen under UV-A radiation and blue light. The experiments show that Cu-doped ZnO-ZnAl2O4 materials demonstrate antibacterial activity against gram-positive bacteria.
Thrombopoietin receptor agonist antibody for treating chemotherapy-induced thrombocytopenia
Authors: Shin Jiwon , Kim Min-Jung , Quan Xingguo , Kim Ji Woong , Lee Sukmook , Park SaeGwang , Jeong Jee-Yeong , Yea Kyungmoo
Published: October 2022

Background: Thrombocytopenia is a common complication in cancer patients undergoing chemotherapy. Chemotherapy-induced thrombocytopenia (CIT) leads to dose reduction and treatment delays, lowering chemotherapy efficacy and survival rate. Thus, rapid recovery and continuous maintenance of platelet count during chemotherapy cycles are crucial in patients with CIT. Thrombopoietin (TPO) and its receptor, myeloid proliferative leukemia (MPL) protein, play a major role in platelet production. Although several MPL agonists have been developed to regulate thrombopoiesis, none have been approved for the management of CIT due to concerns regarding efficacy or safety. Therefore, the development of effective MPL agonists for treating CIT needs to be further expanded.
Methods: Anti-MPL antibodies were selected from the human combinatorial antibody phage libraries using phage display. We identified 2R13 as the most active clone among the binding antibodies via cell proliferation assay using BaF3/MPL cells. The effect of 2R13 on megakaryocyte differentiation was evaluated in peripheral blood CD34+ cells by analyzing megakaryocyte-specific differentiation markers (CD41a+ and CD42b+) and DNA ploidy using flow cytometry. The 2R13-induced platelet production was examined in 8- to 10-week-old wild-type BALB/c female mice and a thrombocytopenia mouse model established by intraperitoneal injection of 5-fluorouracil (150 mg/kg). The platelet counts were monitored twice a week over 14 days post-initiation of treatment with a single injection of 2R13, or recombinant human TPO (rhTPO) for seven consecutive days.
Results: We found that 2R13 specifically interacted with MPL and activated its signaling pathways. 2R13 stimulated megakaryocyte differentiation, evidenced by increasing the proportion of high-ploidy (≥8N) megakaryocytes in peripheral blood-CD34+ cells. The platelet count was increased by a single injection of 2R13 for up to 14 days. Injection of 5-fluorouracil considerably reduced the platelet count by day 4, which was recovered by 2R13. The platelets produced by 2R13 sustained a higher count than that achieved using seven consecutive injections of rhTPO.
Conclusions: Our findings suggest that 2R13 is a promising therapeutic agent for CIT treatment.
Machinability of high strength molybdenum-refined graphite grey cast iron and conventional vermicular automobile engine heads using heptagonal and double-sided carbide inserts
Authors: Reis Alcione dos , de Ataide Matheus Gonçalves , de Souza José Aécio Gomes , Vaughan Luiz Leroy Thomé , Viana Rhander , Machado Álisson Rocha
Published: October 2022

In the current scenario, industry has been faced with growing restrictions imposed by law, aimed at reducing the emission of fuel gases and pollutants into the atmosphere. The automotive industry is seeking to produce vehicles with higher performance to match these needs, so that engines become increasingly smaller, less pollutant and silent. Regulatory factors have guided and contributed to the development of new technologies applied to the internal combustion engine. Depending on such developments, maximum injection and combustion pressures can be achieved, thus, ensuring more efficiency and better performance, in addition to emission reduction. However, recent technology requires engines to withstand even greater mechanical stresses, which can inevitably lead to a component premature failure if no additional improvement are made. Therefore, there has been an incessant search for an alloy capable of replacing conventional gray cast iron, commonly used in the manufacture of blocks, but not yet suitable for high pressures. This work objective is to evaluate the face milling cutting power behavior in FC300 high strength cast iron with the addition of molybdenum and refined graphite, grade (FC300Mo + RG), for application in engine heads, compared to alloys already used for this purpose, such as the FC250 gray cast iron, the FC300 molybdenum alloyed gray cast iron, grade (FC300Mo), and the FV450 vermicular cast iron, grade (CGI).
Homocysteine modulates social isolation-induced depressive-like behaviors through BDNF in aged mice
Authors: Wei Wei-Dan , Lan Yan-Xian , Lu Kun , Wang Yan , Chen Wen-Ying
Published: October 2022

Social isolation is an unpleasant experience associated with an increased risk of mental disorders. Exploring whether these experiences affect behaviors in aged adults is particularly important, as the elderly is very likely to suffer periods of social isolation during their late-life. In this study, we analyzed the depressive-like behaviors, plasma concentrations of homocysteine (Hcy), and brain-derived neurotropic factor (BDNF) levels in aged mice undergoing social isolation. Results showed that depressive-like behavioral performance and decreased BDNF level were correlated with hyperhomocysteinemia (HHcy) levels that were detected in 2-month isolated mice. Elevated Hcy induced by high methionine diet mimicked the depressive-like behaviors and BDNF downregulation in the same manner as social isolation, while administration of vitamin B complex supplements to reduce Hcy alleviated the depressive-like behaviors and BDNF reduction in socially isolated mice. Altogether, our results indicated that Hcy played a critical role in social isolation-induced depressive-like behaviors and BDNF reduction, suggesting the possibility of Hcy as a potential therapeutic target and vitamin B intake as a potential value in the prevention of stress-induced depression.
Evaluation and Attribution of Shortwave Feedbacks to ENSO in CMIP6 models
Authors: Huang Junjie , Li Lijuan , Ran Haiyan , Liu Juan , Wang Bin , Feng Tao , Chang Youli
Published: October 2022

The shortwave (SW) feedback to El Niño–Southern Oscillation (ENSO) is one of the largest biases in climate models, as the feedback includes atmosphere–ocean interactions and cloud processes. In this study, the performance of SW feedback in 19 models from the 6th Coupled Model Intercomparison Project (CMIP6) is evaluated and the biases are attributed using the historical and Atmospheric Model Intercomparison Project (AMIP) runs. The results demonstrate that most CMIP6 models underestimate the strength of SW feedback, although 11 models (~ 58%) show the observed negative signs in the Niño-3 region, a superior result to that (7 of 17, ~ 41%) of CMIP5. The underestimates of SW feedback arise mainly from the biased feedbacks to El Niño in the four models with relatively better skills, while from both underestimated negative feedbacks to El Niño and overestimated positive feedbacks to La Niña in other 15 models, which reproduce better seasonal variations than corresponding CMIP5 models. Furthermore, the SW feedback bias is connected to weak convective/stratiform rainfall feedback, which is sensitive/insensitive to sea surface temperature (SST) biases during El Niño/La Niña. There are different biases among the factors contributing to SW feedback, such as erroneous compensations between underestimated cloud fraction feedback and overestimated liquid water path feedback in the four best-performing models, whereas both are underestimated in the other models, and weakened dynamical feedbacks are observed in all models. The rainfall feedbacks in the AMIP runs are much closer to the observations than those in CMIP5, although they are greatly reduced in the historical runs, indicating that the atmospheric models may be over-tuning under given observed SSTs.
WITHDRAWN: Non-destructive Methods for Evaluating the Physical and Mechanical Aging of Composites
Authors: Maldonado Ignacio Bobadilla , Behzad Hamed Matini , López Roberto Martínez , Hillig Everton
Published: October 2022

Wood-plastic composites (WPC) have been developed into new and important wood-based materials because of their benefits for the environment, their economy and their recyclability. When WPCs are used outdoors, they are subjected to a climate with moisture and temperature fluctuations. It is therefore necessary to obtain information on the effects of climate aging on WPCs. This study explores the relationship between laboratory aging, physical and mechanical changes, and the results of non-destructive testing of wood-polymer composites. This was done by testing 45 pieces of composite with 60% wood fibre, 35% low-density polyethylene (LDPE) and 5% additives. A laboratory aging process consisting of a water immersion at 20 and 50°C for a total of 56 days was carried out on composite specimens. During the aging test, several specimen batches were extracted and tested to record their physical (density) and mechanical properties (bending strength and modulus of elasticity). Non-destructive testing was also carried out with ultrasound and stress wave, screw withdrawal resistance meter and penetration tester devices. Temperature was found to have more influence than humidity on the deterioration of the material. A barely significant decrease in density (2-4%) and a clear drop in mechanical properties (20-60%) was also observed. The non-destructive methods used were reliable estimators of composite properties, especially ultrasound wave propagation, coinciding with previous works on other materials.
Mental health outcomes following COVID-19 infection: impacts of post-COVID impairments and fatigue on depression, anxiety, and insomnia
Authors: Badinlou Farzaneh , Lundgren Tobias , Jansson-Fröjmark Markus
Published: October 2022

Background
The negative impact of the COVID-19 pandemic on the mental health is now clearly established. However, information on the levels of mental ill health of people infected with COVID-19 and potential correlates of poor mental health is still limited. Therefore, the current study aimed to study indicative of potential mental health problems in individuals with a history of probable or confirmed SARS CoV-2 infection/infections and address the impacts of post-COVID impairments and fatigue following COVID-19 infection/infections on depression, anxiety, and insomnia.
Methods
A web-survey including demographics, questions related to COVID-19 status and post-COVID impairments, and standardized measures of depression, anxiety, insomnia, and fatigue was completed by 507 individuals with a history of probable or confirmed SARS CoV-2 infection/infections.
Results
We found significant rates of significant depression, anxiety, and insomnia in our sample, with more than 70% experiencing levels above the clinical cut offs for at least one psychological health problems. Higher levels of depression, anxiety, and insomnia were associated with the severity of COVID-19 infection in the acute phase, hospitalization because of COVID-19, and higher levels of post-COVID impairments and fatigue. Reduced motivation emerged as the strongest predictor for mental ill health.
Conclusions
These findings highlight that individuals infected with COVID-19, especially those who still have experienced post-COVID impairments, are more likely to suffer from mental ill-health and may be more vulnerable for poor mental health outcomes. Therefore, more effective actions are needed to take in order to promote and protect mental health of individuals with a history of COVID-19 infection.
The potential application of MR-derived ADCmin values from 68Ga-DOTATATE and 18F-FDG dual tracer PET/MR as replacements for FDG PET in assessment of grade and stage of pancreatic neuroendocrine tumors
Authors: Gao Jing , Xu Si , Ju Huijun , Pan Yu , Zhang Yifan
Published: October 2022

Purpose
To evaluate the utility of 68Ga-DOTATATE and 18F-FDG PET/MR for prediction of grade and stage of pancreatic neuroendocrine tumors (PNETs), and to examine the correlation between parameters obtained from FDG PET and diffusion-weighted imaging (DWI) MR parameters.
Methods
A retrospective study using 68Ga-DOTATATE and 18F-FDG PET/MR imaging was performed between April 2020 and May 2022 on 46 individuals with histologically confirmed PNETs. Metabolic tumor volume (MTV), maximum standardised uptake value (FSUVmax), and tumor lesion glycolysis (TLG) for FDG; somatostatin receptor density (SRD), maximum standardised uptake value (GSUVmax), and total lesion somatostatin receptor density (TLSRD) for DOTATATE; and minimum and maximum apparent diffusion coefficient (ADCmin and ADCmean) values for MRI, respectively. We performed Spearman's correlation analysis to examine the links between these variables and primary tumor stage and grading.
Results
Higher PNET grading was associated with higher FSUVmax, MTV, and TLG values (P < 0.05). TLG, SRD, ADCmin, and ADCmean values were correlated with N staging, while SRD, MTV, ADCmin, TLG, and ADCmean were associated with M staging. Notably, ADCmin was negative correlation between FSUVmax (r = -0.52; P < 0.001), MTV (r = -0.50; P < 0.001), and TLG (r = -0.56; P < 0.001).
Conclusion
This study highlights significant correlative relationships between FDG PET-derived parameters and ADCmin. ADCmin may offer utility as an alternate tool for PNET staging and grading in lieu of FDG PET. 68Ga-DOTATATE PET/MR alone may be a sufficient alternative to dual tracer PET/MR when conducting grading and staging of primary PNETs.
Tuuned In: Use of an Online Decision Aid Increases Women’s Reproductive Self-Efficacy and Knowledge; Results of an Experimental Clinical Trial
Authors: Mengelkoch Summer , Espinosa Matthew , Butler Stephen A. , Prieto Laura Joigneau , Russell Emma , Ramshaw Chris , Nahavandi Shardi , Hill Sarah E.
Published: October 2022

Background
Digital decision aids are becoming increasingly common in many areas of healthcare. These aids are designed to involve patients in medical decision making, with the aim of improving patient outcomes while decreasing healthcare burden. Previously developed contraceptive-based decision aids have been found to be effective at increasing women’s knowledge about reproductive health and contraception. Here, we sought to evaluate the effectiveness of a novel contraceptive-based decision aid at increasing women’s self-efficacy and knowledge about their reproductive health and contraceptive options, as well as their perceptions of their learning. This study was registered as a clinic trial at ClinicalTrials.gov (Contraception Decision Aid Use and Patient Outcomes, ID# NCT05177783) on 01-05-2022.
Methods
The Tuune→ contraceptive decision aid’s effectiveness was evaluated by conducting an experiment in which 324 women were assigned to use the TuuneⓇ decision aid or a control decision aid. Primary outcomes included reproductive health self-efficacy, reproductive health and contraceptive knowledge, and perceptions of learning. Secondary analyses examined whether prior experience using hormonal contraceptives moderated the relationship between decision aid and each outcome measure.
Results
Women assigned to use the Tuune→ decision aid exhibited greater reproductive health self-efficacy, greater knowledge about reproductive health and contraception, and perceived having learned more than women assigned to use the control decision aid. This pattern was also observed in women with previous contraceptive use experience, where women using TuuneⓇ reported better outcomes than women using the control aid, regardless of their history of hormonal contraceptive use experience.
Conclusions
Use of the Tuune→ contraceptive-based decision aid improved each of the predicted outcomes relative to a control decision aid. This suggests that use of the TuuneⓇ contraceptive-based decision aid is well poised to increase women’s confidence and knowledge about contraceptive use and may also reduce burden on healthcare systems.
A Randomized Clinical Trial comparing Immediate to MOdified DElayed coloanal anastomosis after total mesorectal excision: the IMODE trial protocol
Authors: Bendib Hani , Anou Abdelkrim , Djelali Nabil , Oukrine Hind , Lahrech Said , Azzouz Abdelghani , Chekman Chemseddine , Djennaoui Azeddine
Published: October 2022

Purpose
Immediate coloanal anastomosis (ICA) remains the standard technique for restoring the digestive tract after proctectomy for low rectal cancer. Often, it requires a temporary diversion stoma, thus increasing the risk of complications. Recent data have shown a great potential of the delayed coloanal anastomosis (DCA) both in decreasing anastomosis morbidity and in avoiding ileostomy to the patients. More recently, a modified delayed coloanal anastomosis (mDCA) has been described and seems to have promising results. This study aims to determine whether mDCA is non-inferior to ICA.
Methods
The IMODE trial is a randomized, controlled, non-inferiority trial designed to enroll 70 adults with mid or low rectal cancer. Participants are randomized to ICA or mDCA. The primary endpoint is the anastomotic fistulas (AF) rate at 6 months.
Conclusions
The mDCA can constitute an interesting modality to restore the digestive tract following proctectomy for mid and low rectal cancer; this by decreasing the morbidity of the coloanal anastomosis on the one hand and by avoiding ileostomy on the other hand.
Trial registration
PACTR202209500145137, September 9th, 2022 (retrospectively registered).
Road Safety Analysis Framework Based on Vehicle Vibrations and Sounds using Deep Learning Techniques
Authors: P Rithesh Pakkala , R Akhila Thejaswi , B Shamantha Rai , R Nagesh H
Published: October 2022

Road accidents in India occur due to potholes. These potholes are not repaired because the authorities will not be aware of it unless the public raises an issue. Lack of adequate techniques to identify potholes has caused huge trouble to the public. The primary goal of this study is to build a deep learning model that would analyze the patterns in the sound recording of the vehicles and label the Road Anomaly Events (RAEs). Deep learning techniques like Convolutional Neural Network (CNN) and BLSTM are used to classify the sound signature and then are labelled accordingly. The idea can be implemented in areas where there is regular movement of vehicles to identify the exact locations of the pothole and inform the concerned authorities so that the public can experience smoother roads. From the analysis, it is found that the model has an accuracy of 83% with ADAM Optimizer while RMSProp produces 54–60% accuracy.
Dynamic performance of a novel tuned vibration absorber with nonlinear friction interfaces
Authors: Wang Yongfeng , Ma Yanhong , Wang Hong , Firrone Christian Maria , Hong Jie
Published: October 2022

A novel tuned vibration absorber with frictional interfaces (FTVA) is proposed in this study, combining advantages of the tuned absorber and the nonlinear dry friction damping to dissipate the energy. First, the influence of the mechanism of the nonlinear dry friction damper is introduced using a simplified model with 1-dof tuned mass absorber and the hysteresis friction contact element. Second, a real layout for the FTVA is proposed using a metal strip to tune the vibration absorber, and introducing three frictional contact interfaces with variable normal loads. Both numerical and experimental studies have been carried out which indicate the effectiveness of the novel FTVA. For a well-tuned absorber with properly designed frictional interfaces, the vibration amplitude can be reduced more significantly, and the actual frequency range where vibration amplitudes are limited can be broadened with respect to a classical TVA. The nonlinear contact element contributes to avoid the additional peak vibration generated by the tuned ordinary absorber since the friction damping will be activated as the system response increases to a threshold value. Effects of contact parameters, such as the normal load of the interface, have been deeply investigated as well, which can be optimized to minimize the vibration amplitude. Basic performance of the novel FTVA have been revealed, indicating the potential to suppress vibrations of engineering structures.
Growth performance, nutrient digestibility, antioxidant status and metabolic enzyme activity in pearlspot (Etroplus suratensis), fed carbohydrates of different complexities
Authors: Ramachandramoorthi Raguram , Pradhan Chiranjiv , Kalaivanan Rajalakshmi , Sashidharan Abhilash , Jena Srikanta , Mohanta Kedar Nath
Published: October 2022

A 60-days feeding study was conducted to assess the capacity of pearlspot, Etroplus suratensis to utilize different complexity of carbohydrate in growth performance, nutrient digestibility, antioxidant status, metabolic and digestive enzyme activity and histology of liver. Five isonitrogenous (35%) and isolipidic (7%) diets were formulated to contain 35% of glucose (GLU-feed), sucrose (SUC-feed), dextrin (DEX-feed), starch (STA-feed) and cellulose (CEL-feed), respectively. The survival and condition factor were not affected (p > 0.05) by the diets. Fish fed with the STA-feed showed significantly (p < 0.05) higher weight gain and specific growth rate. The feed efficiency ratio and protein efficiency ratio were significantly higher (p < 0.05) and alike in STA-feed and Dex-feed groups. Except for protein, the other whole-body composition was affected significantly (p < 0.05) by the different carbohydrate sources. The activities of antioxidant enzymes were significantly (p < 0.05) higher in groups fed on complex carbohydrate diets when compared to simple forms. Simillarly, the protease enzyme activity was also significantly (p < 0.05) higher in starch and cellulose fed groups. Significantly (p < 0.05) higher dry matter digestibility was recorded in starch fed group. STA-feed group increased the specific activity of malate dehydrogenase and hexokinase.The glucose 6 phosphate dehydrogenase (G6PDH) activity was significantly (p < 0.05) higher in the GLU-feed group, and gradually decreased with increase in the complexity of carbohydrates.The DEX-feed and CEL-feed groups showed heavy fatty change with numerous large lipid droplets as compared to other groups. Overall, these results indicate that dietary starch was more efficiently utilized than other carbohydrate sources by pearlspot.
Fading of rhodamine B using CdS quantum dots under solar light
Authors: Sivakumar K. , Poongodi T.
Published: October 2022

Plate like cadmium sulfide (CdS) quantum dots were prepared by using β-cyclodextrin as reductant. Photoluminescence and uv-visible diffused reflectance spectroscopic techniques are used to investigate the optical property of CdS. The blue shifted emission of CdS at 469nm than the bulk particle is observed. The calculated band gap of CdS quantum dot is 2.62 eV showed a difference of 0.2 eV energy greater than that of bulk, indicating quantum size effect. The synthesized quantum dot has size in the range of 3.5nm with zinc blende crystallite structure. The plate like nanoclusters of CdS are inferred from SEM images. The photocatalytic efficiency of prepared CdS was tested for the degradation of rhodamine B dye using natural solar light. Effect of weight of catalyst, concentration of dye, pH of solution and reusability of catalyst were investigated. Existence of isosbestic point observation of high intense absorbance peak at 550nm at 300min in different matrix circumstances confirms the formation of leuco Rh B.
Primary Biliary Tract Cancers in Golestan, Iran: 13-year experience of Golestan Population-based Cancer Registry (GPCR)
Authors: ashkbari Ali , Amlashi Fazel Isahpanah , Besharat Sima , mofidi Mostafa , Amiriani Taghi , Fazel Abdolreza , Alimadadi Mehdi , Salamat Faezeh , Sedaghat SeyyedMehdi , Livani Somayeh , Bagheri Ali , Semnani Shahryar , Norouzi Alireza , Roshandel Gholamreza
Published: October 2022

The authors have requested that this preprint be removed from Research Square.
Basement membrane genes can predict the prognosis of patients with clear cell renal cell carcinoma (ccRCC) and are correlated with immune status
Authors: Hou Junhui , Lv Zongwei , Wang Yuan , Wang Xia , Chen Xiaonan , Wang Kefeng
Published: October 2022

Background: Basement membrane (BM) genes are an important factor in the process of clear cell renal cell carcinoma (ccRCC). Thus, identifying BMs with prognostic values in ccRCC is critical.
Methods: The samples from TCGA were separated randomly into 2 cohorts, the training cohort, and the validation cohort. For the training cohort univariate Cox, Lasso, and multivariate Cox regression analyses were applied to identify prognostic BM genes and then construct a prognostic BM-genes’ signature. The nomogram was applied to predict prognosis at different clinicopathological stages and risk scores. GO and KEGG analyses were applied to the differentially expressed genes. Moreover, the CIBERSORT and ESTIMATE scores were calculated and compared between the high-risk cohort and the low-risk cohort.
Results: A prognostic risk model of four BM genes, including ADAMTS14, COL7A1, HSPG2, and TIMP3, was constructed. There were also significant differences in survival time between the high-risk and low-risk groups for the validation cohort and the entire cohort. The risk model was validated as a new independent prognostic factor for ccRCC by univariate and multivariate Cox regression together with clinicopathological characteristics. In addition, a nomogram showed good prediction. The model can also analyze the possibility of immune escape and response to immunotherapy in ccRCC patients. In addition, the results of a pan-cancer analysis showed that these four model genes were associated with immune-related genes in a variety of cancers.
Conclusion: The signature of four BM genes had a significant prognostic value for ccRCC. They may be promising targets for therapy, especially immune therapy.
Automated Classification of Well Test Responses in Naturally Fractured Reservoirs Using Unsupervised Machine Learning
Authors: Freites Alfredo , Corbett Patrick , Rongier Guillaume , Geiger Sebastian
Published: October 2022

Understanding the impact of fractures on fluid flow is fundamental for developing geoenergy reservoirs. Pressure Transient Analysis (PTA) could play a key role for fracture characterization purposes if proper links are built between the pressure derivative responses () and the fracture properties; however, the PTA process is particularly challenging in the presence of fractures because they can manifest themselves in many different . Our work aims at providing a tool for effectively handling the diversity in fracture-induced by automatically classifying them and identifying characteristic patterns in the data. To represent this diversity of in naturally fractured reservoirs, we created a synthetic dataset from numerical simulation that comprised 2560 , corresponding to 10 stochastic realizations of 256 combinations of different fracture intensities and average fracture apertures, organized in two orthogonal fracture sets. To group the , we developed an unsupervised maching learning approach that can distinguish beyond the variable temporality of the signals by leveraging the dynamic time warping algorithm in a k-medoids clustering. Our results suggest that the approach is effective at recognizing similar shapes in the first pressure derivatives if the second pressure derivatives are used as the classification variable. The analysis of the Naturally Fracture Reservoirs dataset indicated that 12 clusters were appropriate to describe the full collection of . We suggest that the respective cluster medoids can be regarded as reference curves for various Naturally Fractured Reservoirs and be used as a guide in the interpretation of real well tests. The classification exercise also allowed us to identify the key geological features that influence the , namely 1) the distance from the wellbore to the closest fracture(s), 2) the local/global fracture connectivity, and 3) the local/global fracture intensity.
Neuroticism among medical students at a federal public university: a cross-sectional analysis
Authors: Poles Kátia , Almansa Joice Franciele Friedrich , Braz Mirian Silvia , Hutz Claudio Simon
Published: October 2022

Introduction: Neuroticism is a personality dimension characterized by an individual's tendency to experience negative emotions. Individuals with high levels of neuroticism are more likely to experience emotional distress and mental illness.
Objective: To evaluate levels of neuroticism, including its facets, among medical students at a federal public university and compare them to groups in the general population.
Method: Cross-sectional, descriptive, and quantitative study. A total of 317 medical students from a federal university in Brazil, participated; 171 (53.94%) were female and 146 (46.06%) were male. A sociodemographic questionnaire and the Revised Neuroticism Factor Scale were applied for collection between February and June 2021. Data analysis procedures were performed using SPSS. Student t-tests for one and independent samples were applied for gender comparison.
Results: The sample means, categorized by gender, were compared with the population means presented in the technical manual of the test. Higher scores were evident in neuroticism and the facets of vulnerability, embarrassment, impulsivity, and anxiety/preoccupation when compared to the baseline study. Both genders were also found to have higher levels of embarrassment and anxiety/concern, and males also showed higher scores on neuroticism, vulnerability, and impulsivity. In the comparison test between genders, higher scores were observed in females for neuroticism and depression, vulnerability, embarrassment, and anxiety/concern.
Conclusion: Given the above, the need for psychological support for medical students is reinforced, for both genders, given the professional specificities in which they are immersed. Moreover, identifying the protective factors is an essential prerequisite for the design of health promotion interventions.
The negative consequences of the SARS-CoV-2 pandemic on the health of mother and child considering maternal childhood maltreatment
Authors: Köhler-Dauner Franziska , Gulde Manuela , Hartmann Lara , Ziegenhain Ute , Jörg M. Fegert
Published: October 2022

Background
Preventive isolation and social distancing strategies during the SARS-CoV-2 pandemic have confronted families with a variety of different limitations and pressures like preventive isolation and school closures. Especially in this stressful time, children need a stable parental home to prevent developmental consequences. Additional risk factors such as maternal childhood maltreatment (CM) may affect mother’s psychosomatic health and children’s physical well-being in times of increased stress such as during the ongoing pandemic.
Objective
We aimed to analyze the interplay between maternal CM, mother’s mental health, and children’s physical complaints during the SARS-CoV-2-pandemic.
Method
Mothers of a well-documented birth cohort for investigating the pathways leading to resilience or vulnerability in the transgenerational transmission of CM were imbedded in an online “SARS-CoV-2 pandemic survey” assessing mother’s psychosomatic health and children’s physical health during the pandemic. 159 mothers completed the online survey. To describe the maternal CM, data from a longitudinal survey were used.
Results
Our mediation analysis demonstrates a significant positive association between the sum of maternal CM experiences, maternal psychosomatic symptoms, and their children’s physical health complaints. The maternal psychosomatic symptoms significantly mediate the interplay between CM and children’s physical health complaints, the direct effect does not remain significant when the maternal psychosomatic symptoms were included as mediator.
Conclusions
Maternal CM seems to be one relevant risk factor for mother’s psychosomatic health and children’s physical well-being during a stressful time like a pandemic. Maternal CM experiences seem to influence the way how parents deal with stressful situations and increase the risk to suffer depressive symptoms. The latter impact also their children’s physical well-being. Our results highlight the importance to carefully assess the specific situation of families with children and to provide individually adjusted assistance to help the families to get through the pandemic.
Molecule stapling-assisted fabrication of high-quality CsPbI2Br films for efficient and stable photovoltaic modules
Authors: Chen Ruihao , Du Jieru , Zheng Xuan , Li Feiming , Guo Pengfei , Liu Zhe , Wang Hongqiang
Published: October 2022

CsPbI2Br perovskite solar cells (PSCs) are a suitable bandgap for the fabrication of tandem solar cells and have excellent thermal stability. However, their halide phase separation and water instability lead to challenges for practical industrialization. Here, a molecular stapling strategy is demonstrated to assist in the fabrication/stabilization of a high-quality large-area CsPbI2Br film by using a series of cesium perfluorodioate salts. According to density functional theory and experimental attempts, hexafluoroglutarate anions possessed a stronger interaction between chelated oxyen and surface Pb2+ ions due to the matchable stapling configuration, which effectively improved moisture tolerance, reduced defects and further improved the phase stability of the CsPbI2Br films. In the prepared high-quality CsPbI2Br films, the fabricated PSCs achieved 16.4% efficiency in a small area. The devices displayed high stability, retaining ~91% of the initial efficiency for more than 1000 h under 85 °C and N2 conditions and ~90% for 2000 h at a relative humidity of 20% without encapsulation. More importantly, this developed strategy can be employed for the production of large-area perovskite solar modules. A mini perovskite solar module with an efficiency up to 12.4% in a large area of 16 cm2 was successfully fabricated.
A Deep Learning-Based Multi-model Approach to Sentiment Analysis
Authors: Sarkar Avik , Rakshit Pranati
Published: October 2022

Nowadays, all over the world a great deal of data is being created every day at every instant through several electronically driven social platforms namely Facebook, WhatsApp, Twitter, etc. Data thus created may consist of negotiation between a businessman and a customer during the online purchase of different things, Chit-chat between friends by using different types of emojis, an online discussion between the educationists and the students, and pasting and uploading of interesting pictures and videos, etc. People from all spheres of society are engaged in expressing their views and sentiments through these worldwide networking systems. At the same time in recent days, several powerful machines and deep learning tools have emerged to analyse this huge bulk of data to visualize the social, economic, political, and psychological scenarios of different communities, states, and nations. In this article, the authors have adopted a deep learning-based multimodal approach to investigate and compare the efficiencies of different deep learning architectures namely Multi-Layered Perceptron (MLP), Recurrent Neural Network (RNN), Bi-directional RNN, Long and Short Memory (LSTM), Bi-directional Long and Short Memory (Bi-LSTM) have to carry out the important task of sentiment analysis. The noticeable results, conclusions, and applications that emerged from the study will be discussed in a systematic manner. Some relevant references consulted during the literature survey of this work will be presented afterward. Finally, the authors acknowledge the helps they have received during the successful completion of this article.
Association of polymorphism of the enzyme catechol-o-methyltransferase with fibromialgic syndrome and its clinical repercussions
Authors: Junior Juares Antonio Cividini , Souza Jéssica Azevedo Moraes , Bulhões Gevanil Lene Arruda , Pelloso Lia Rachel Chaves do Amaral , Santos Fabrício Rios , Galera Bianca Borsatto
Published: October 2022

Background: Fibromyalgia syndrome (FMS) is a clinical condition that mostly affects women of working age, with chronic diffuse pain, physical disability, mood swings, anxiety, fatigue and insomnia. Although its pathophysiology is not fully understood, it is believed that there are genetic contributions to its origin. There is evidence that some single nucleotide polymorphisms (SNPs) can change the function of proteins that participate in pain modulation, increasing the individual's susceptibility to pain processes. Catechol-O-methyltransferase (COMT) is an enzyme responsible for the inactivation of catecholamines in the central nervous system, participating in descending nociceptive inhibitory pathways. Polymorphisms in the gene encoding COMT can impair its formation and, consequently, its function, accentuating painful conditions in FMS patients. This study verified the association of SNPs rs4680, rs6269, rs4633 and rs4818 of the COMT gene with clinical aspects in patients with FMS undergoing treatment in public and private health services in Cuiabá, Mato Grosso Estate, Brazil.
Methods: Forty-seven volunteers who underwent medical follow-up by FMS were selected, in which the Fibromyalgia Impact Questionnaire, the Beck’s Depression and Anxiety Inventories, the Insomnia Severity Index and the Mini-Mental State Examination were applied, in order to evaluate the clinical repercussions of the disease. Blood samples were collected for genetic evaluation. The DNA was extracted by salting out and the SPNs were evaluated by real time reverse transcription polymerase chain (RT-PCR). The association between clinic and SPNs was tested by the Fisher's exact test. A 95% CI and p value < 0.05 were adopted.
Results: The results showed that there was no association between such SNPs and the participants' clinic regarding the tests used.
Conclusions: This study showed that, although the disease has an important impact on patients' daily lives, increasing the chances of depression, anxiety, insomnia and cognitive losses, it is not associated with the SNPs researched. Further investigations, with larger samples, are needed to assess these and other associations between genetics factors and FMS.
Indicators of cutting removal efficiency when drilling directional wells
Authors: Lambin A. I.
Published: October 2022

Borehole cleaning is still a major challenge for most directional wells despite a significant progress achieved in drilling fluids, tools and field practice, as well as in the development of academic and industry research. Insufficient cleaning of the borehole causes undesirable phenomena in the form of various complications. Therefore, the purpose of the conducted research was to present the main correlations that determine the nature and cleaning degree of the annular eccentric space of the well and to analyze these correlations presented in the form of indicators in order to improve them. The object of the research is the mechanics of cuttings removal from an inclined or horizontal well. In the frameworks of this research mechanics is mathematically displayed in the form of indicators reflecting one or another physical aspect of the cuttings removal process. The research methodology consists in the analysis of the composition of indicators, evaluation of the significance of the indicator constituents, identification of the quantitative contribution of the indicator to the cleaning degree of the annular space of the directional well from destruction products while sinking the borehole. The study resulted in the introduction of the following indicators: equivalent circulation density, slip velocity and cuttings removal index. The physical essence of indicators in their mathematical form is shown with the focus on the slip velocity. The definition of the latter, which is widely accepted among the specialists indicates the rate of washing of cutting particles by the drilling fluid during its transportation to the day-light surface. This indicator is one of the main ones that determine the hydrodynamics of the cuttings transport process. To simplify the calculation of the indicator, it is proposed to use the dimensionless Lyashchenko criterion.
Influence of hydrodynamic effects on dispersoid structural changes under microdisintegration
Authors: Khrunina N. P.
Published: October 2022

The purpose of the presented study is to give a theoretical substantiation of the formation process of a high-clay sand dispersoid from placers with a high content of fine and finely dispersed gold under changing hydrodynamic parameters of the hydro mixture flow by means of enclosing and reflecting surfaces of the proposed installation. The object of the research is the process of hydrodynamic disintegration. The subject of the study includes the main parameters of the hydrodynamic effect on the mineral environment and the destruction nature of high-clay sands under hydrodynamic conditions. While doing the research, the author used the methods for constructing a mathematical model of dispersoid transformation under hydrodynamic effect on the hydro mixture, analytical and numerical calculations. The analysis of the aspects of hydrodynamic phenomena and interactions made it possible to substantiate the dispersoid formation process based on the intensification of microdisintegration and to identify the characteristic impact factors as well. Based on the theory of changes in the thermodynamic potential of the system of particle surfaces under dynamic exposure, a method has been proposed for determining the hydrodynamic variation parameters of the hydromixture structural component in the closed cavity of the generator when interacting with the elements of the enclosing and reflecting surfaces. The performed numerical calculations allowed to reveal a significant increase in the specific interphase surface of the dispersoid of the mineral component. The interaction of the elements of enclosing and reflecting surfaces according to the proposed innovative layout of elements location in the generator under the directed supply of the hydromixture from the nozzle into a closed cavity resulted in the increase from 3 to 4 times. A new design of a hydrodynamic generator and a flow diagram have been introduced on order to activate the extraction process of microparticles of valuable components.
Classification of Convergent OPE Channels for Lorentzian CFT Four-Point Functions
Authors: Qiao Jiaxin
Published: October 2022

We analyze the convergence properties of operator product expansions
(OPE) for Loren-tzian CFT four-point functions of scalar operators. We
give a complete classification of Lorentzian four-point configurations.
All configurations in each class have the same OPE convergence
properties in s-, t- and u-channels. We give tables including the
information of OPE convergence for all classes. Our work justifies that
in a subset of the configuration space, Lorentzian CFT four-point
functions are genuine analytic functions. Our results are valid for
unitary CFTs in d\geq2d≥2.
Our work also provides some Lorentzian regions where one can do
bootstrap analysis in the sense of functions.
Mobile Technologies for Developing Intercultural Competence in Students of International Relations at Foreign Language Classes
Authors: Yurchenko Margarita
Published: October 2022

This article provides qualitative and quantitative data to establish the effectiveness of virtual tools as a means of developing intercultural competence in students of international relations at foreign language classes. Intercultural competence is known to be crucial for this field of studies. However, no teaching technologies exist for its development at foreign language classes, and available research publications on this issue fail to take into account the current state and mechanisms of global communication. The empirical part of this study involved a survey of students of international relations during the first term of 2021–2022. The author compared their performance in class and during extracurricular activities, where they had to maintain an English blog. A total of 93 second- and third-year students (experimental + control groups) took part in the trial training, and 50 people (28 students, 22 teachers) participated in the independent assessment of the technology. The blog operating process was divided according to types of virtual intercultural communication (oral-written, mixed, and oral) and followed the academic program. The independent assessment was performed by academic staff and students who didn't participate in the experiment, but were able to observe. They unanimously approved of the new technology and defined the prospects of its further implementation. Blogging in a foreign language proved to be an efficient technology for developing intercultural competence in university students majoring in international relations.