bluuebunny/crossref_metadata_2025 huggingface dataset:
Abstract 3097: Platelet COX-1 Dependent And Independent Heterogeneity In Response To Low-Dose Aspirin
Authors: Zheng Xiaoying , Luttrell-Williams Elliot , Barrett Tessa , Berger Jeffrey
Published: July 2024

Background:
Platelets are key mediators of thrombosis and hemostasis. While aspirin decreases cardiovascular events in high-risk populations, its pharmacological and therapeutic effect is limited by heterogeneity in response and its effect on COX-1 dependent and independent pathways. We sought to investigate the heterogeneity of response of low-dose (81mg/day) aspirin.

Methods:
Following an overnight fast, 39 healthy controls had 4 weekly phlebotomies and received 81 mg aspirin daily between weeks 3 and 4. At each collection, platelet activity was measured using light transmission aggregation (LTA) in response to arachidonic acid (AA [1.5 mM];
COX-1 dependent
) and epinephrine (2.0 μM), ADP (2.0 μM), and collagen (1.0 μM;
COX-1 independent
pathways).

Results:
Median age was 27 (21, 59) years, 48.7% were female, 53.9% were white, and 7.7% were Hispanic. Median platelet aggregation in response to AA (1.5 mM) was 90.9%, 91.6%, and 91.4% in weeks 1, 2, and 3, demonstrating a robust reproducible response. Baseline AA-induced platelet aggregation was modestly correlated with ADP- (r=0.28, p=0.054), collagen- (r=0.42, p=0.0036), and epinephrine-induced (r=0.32, p=0.029) platelet aggregation. Following 1 week of aspirin, AA-induced platelet aggregation decreased to 11.8% (p<0.0001). The median (interquartile range) platelet inhibition in response to AA was 87.3% (78.5%, 92.5%) demonstrating a robust COX-1 dependent response. Platelet inhibition in response to epinephrine (52.1% [46.4, 62.6]), collagen (79.5% [70.3, 87.4]), and ADP (29.8% [22.0, 36.0]), albeit statistically significant, was less robust. While platelet inhibition in response to AA was correlated to platelet inhibition in response to collagen (r=0.64 p=1.12E-5) and epinephrine (r=0.44, p=0.0052), there was no correlation in response to ADP (r=-0.04, p=0.81) induced platelet inhibition.

Conclusions:
Our findings demonstrate a robust COX-1 dependent aggregation response and a more heterogeneous COX-1 independent aggregation response to low-dose aspirin. The mechanism and clinical significance of these findings require further study.
Abstract 3100: BRCA1-RpL17 Interaction Regulates Angiogenesis
Authors: Shaposhnikov Michal , Berk Bradford C
Published: July 2024

Background:
Angiogenesis, forming new blood vessels from existing ones, is crucial in development, diabetes, and cancer. We found that Large Ribosomal subunit protein 17 (RpL17) played a key role in endothelial cell (EC) proliferation and angiogenesis. Reduced RpL17 (KD) promoted angiogenesis in human ECs and RpL17-deficient mouse retinas. RNA-sequencing and bioinformatics suggested a role for Early growth response 1(EGR1) transcription factor. Bioinformatics revealed Breast Cancer gene 1 (BRCA1) as a potential upstream regulator of RpL17, suggesting a novel pathway for angiogenesis.

Hypothesis:
BRCA1 interacts with RpL17 and upregulates EGR1 to stimulate vessel elongation in angiogenesis.

Goal:
Determine the role of BRCA1-RpL17 interaction in angiogenesis and their potential feedback loop via EGR1.

Methods/Approach:
RNA-sequencing of mouse ECs, whole retina mount staining (comparing wild-type and RpL17+/- mice). Tube formation assays with HUVECs to investigate angiogenesis after RpL17, BRCA1, and EGR1 knockdowns. Bioinformatics analysis with Python for RNA-seq data. Immunoblotting and RT-qPCR to measure protein and DNA expression. Immunofluorescence (IF) staining of HUVECs to observe BRCA1, RpL17, and EGR1 expression and localization.

Preliminary Results:
Whole retina mounts showed increased angiogenesis in RpL17-deficient mouse retinas compared to wildtype (p<0.009). HUVECs with RpL17 KD had increased junctions and longer branches than control HUVECs (p<0.0002). RNA-seq identified increased EGR1 expression (q<2.5x10
-8
) in RpL17 KD ECs, confirmed with RT-qPCR (p<0.002). Bioinformatics predicted BRCA1 as a regulator of RpL17. HUVEC IF staining showed decreased RpL17 expression after BRCA1 KD. Angiogenesis assays of BRCA1 KD ECs exhibited an angiogenic phenotype like RpL17 KD, rescued following double BRCA1/RpL17 KD.

Conclusion:
BRCA1-RpL17 interaction stimulates angiogenesis and may be regulated by an EGR1 feedback loop, likely by EC proliferation. Detailed understanding of this pathway will provide new therapies to regulate angiogenesis.
Abstract 3102: NELISA High-throughput Proteomics Captures Disease Phenotypes And Cytokine Interactions By Quantifying Immune, Metabolic, And Cardiovascular Markers
Authors: Robichaud Nathaniel
Published: July 2024

The variety of cell types and interactions involved in vascular diseases pose a significant challenge to quantifying the breadth of inflammatory, metabolic, and cardiovascular proteins that could provide mechanistic information or serve as clinical biomarkers, particularly at the scale needed for population studies or drug discovery screens. Unfortunately, proteomics tools able to quantify these proteins compromise either content or throughput/cost, limiting their use. To overcome this issue, we developed the nELISA: a high-throughput miniaturized ELISA capable of quantifying 272 cytokines, adipokines, proteases, soluble receptors, and growth factors, at 10x-reduced cost compared to previous tools. We applied the nELISA to model systems as a proof-of-concept for use in high-throughput screens.

We ran the largest PBMC secretome screen to date, in which ~10,000 PBMC samples were profiled at a throughput of 1536 samples/day. Cells were treated with a selection of myeloid and T cell stimuli to model different disease states, and were further perturbed with a selected library of 80 recombinant cytokine perturbagens; secreted proteins were profiled in all samples, resulting in ~2M datapoints. In addition to distinguishing the various disease states, the nELISA captured 449 cytokine interactions, where addition of a specific perturbagen resulted in a change in the expression levels of a secreted protein. Of note, we found 3.2-fold more of these interactions than reported at the transcriptomic level from the CytoSig database. By clustering these cytokine interactions, we identified perturbagens with shared mechanisms of action, including results supporting the use of IL-1 Receptor antagonist to replace IFN beta in certain indications. We will expand on these findings and discuss how the nELISA is being applied to HUVEC cultures, whole blood assays, and patient plasma/serum.
Abstract 3113: Modeling Varicose Vein Using Induced Pluripotent Stem Cells
Authors: Noishiki Chikage , Adkar Shaunak S , Wu David , Liu Lu , Turbes Naima C , Tripathi Dipti , Manhas Amit , Thomas Dilip , Sallam Karim , Lee Jason T , Leeper Nick J , Klarin Derek , Fukaya Eri , Sayed Nazish
Published: July 2024

Background:
Varicose veins (VV) pathogenesis is multifactorial and has been attributed to both genetic and epigenetic factors. Vein wall dilation occurs concurrently or because of the venous hypertension and inflammation, further exacerbating the venous reflux. These effects are due to changes in the endothelium (ECs) and smooth muscle cells (SMCs), and their impaired cross-talk that play an important role in venous constriction. Due to limited access to ECs and SMCs from patients, the molecular mechanisms underlying vascular dysfunction in VV remain largely unknown.Induced pluripotent stem cells (iPSCs) provide a unique platform to recapitulate the disease phenotype in vitro thereby allowing unprecedented access to patient-specific cells. iPSCs derived from somatic cells possess the ability to differentiate into multiple cell types, including protein expressing ECs and SMCs. Furthermore, iPSC-derivatives are patient-specific, i.e., the encoded proteins are dictated by the genome of the original somatic donor cell.

Goals:
By creating iPSCs from VV patients, we can model and characterize to recapitulate the disease phenotype. With these efforts, our goal is to elucidate the underlying disease mechanisms and validate the candidate genes that are, in part responsible for VV.

Methods:
We have recruited 32 VV patients in our Stanford clinic. Peripheral blood mononuclear cells (PBMCs) are to be isolated. Patient-specific iPSC lines are generated from patients with VV and differentiated to ECs and SMCs.

Results:
Our lab has developed a robust, chemically defined monolayer differentiation protocol for iPSC-ECs that consistently yields about 80-95% CD31+ cells. Using this approach, I differentiated iPSCs from both the control and VV patients to ECs. The expression of specific cell type markers (PECAM1, NOS3, CDH5, VWF) were determined by RT-qPCR.

Conclusion:
Our patient-specific iPSC will become possible to model individual responses to treatment and medications and to find variants that lead to differences in outcomes. However, the clear demarcation between venous and arterial phenotypes was not assessed. Therefore, our future strategies will determine the functional and developmental differences between venous and arterial iPSC-ECs.
Abstract 3131: An Investigation Into The Interplay Between Epha2 And Inflammatory Responses In Vascular Smooth Muscle Cells
Authors: Shum Alika , Scott Matthew L , Pearson-Gallion Brenna , Cockerham Elizabeth D , Orr Anthony W
Published: July 2024

Cardiovascular disease continues to be a leading cause of death in the United States. A major underlying cause of cardiovascular events such as stroke and myocardial infarction is atherosclerosis. Notable mediators in the pathogenesis of atherosclerosis include vascular smooth muscle cells (VSMCs) and inflammation. During atherogenesis, the SMCs undergo phenotypic change from a quiescent state to a synthetic, proliferative state. The synthetic SMCs drive neointima formation which influences the stenosis characteristic of atherosclerosis. Signaling of a receptor tyrosine kinase called EphA2 has been previously determined to have a role in SMC phenotypic change. It was found that a global and SMC specific knockdown (KD) of EphA2 resulted in decreased plaque formation, suggesting the role of EphA2 expression in promoting SMC proliferation. Inflammation is another important factor that contributes to plaque formation. Oxidized low-density lipoproteins (LDLs) have been found to also cause VSMCs to undergo change to a synthetic phenotype, one that resembles macrophages. Cytokines released by macrophages orchestrate the pro-inflammatory response that affects the development and stability of atherosclerotic plaques. Considering the important role inflammation also serves in the progression of plaque formation, we investigated the relationship between EphA2 and VSMC-mediated inflammatory response. Cre-flox breeding was performed to achieve EphA2 knockout (KO) specifically in VSMCs of 8-10-wk old ApoE -/- mice. Successful KO was confirmed with PCR and Western blot. Si-RNA was transfected to achieve KD in human SMCs. The cells were then treated with cytokines, including IL-1 beta, TNF-alpha, IL-6, IL-33, and interferon-gamma, followed by RT-qPCR analysis to measure expression of inflammatory genes. To assess cytokine secretion, we utilized a cytokine array to measure presence of the cytokines of interest. Protein analysis to quantify expression of inflammatory proteins in KO vs control cells was done via Western blot. We observed that the loss of EphA2 causes significant reductions in the production of several proinflammatory cytokines and chemokines, indicating its role in mediating VSMC inflammatory responses.
Abstract 3139: Evidence Of Vascular Endothelial Dysfunction In Habitual Hookah (i.e., Waterpipe) Users: Insights For Cardiovascular Disease Risk
Authors: Rezk-Hanna Mary , Cheng Chiao-Wei , Brecht Mary-Lynn
Published: July 2024

Introduction:
Flavored hookah tobacco smoking among young adults continues to be a public health concern. While short-term exposure to flavored hookah tobacco smoking impairs vascular function, data on the long-term impact of habitual use are not clearly delineated.

Research Question:
Is habitual flavored hookah tobacco smoking associated with vascular endothelial dysfunction in young healthy adults?

Goals:
Investigate the impact of regular flavored hookah tobacco smoking on vascular endothelial function, as compared to regular cigarette smoking and never tobacco use, in young healthy adults.

Methods:
We assessed brachial artery flow-mediated dilation (FMD)—a well-established index of vascular endothelial function—in 22 exclusive chronic hookah smokers (25±1 years of age, 23% women; mean±SE), who reported smoking flavored hookah tobacco on average two times per week for 9±1 years, 22 exclusive cigarette smokers who reported 4±1 pack years, and 23 non-smokers. FMD and vascular endothelium-independent nitroglycerin-mediated vasodilation was assessed using high resolution ultrasound.

Results:
Whereas baseline brachial artery diameter was comparable between groups (
P
=ns), brachial artery FMD was significantly lower in habitual hookah users and cigarette users as compared to never smokers (cigarette smokers: 5.22±0.42; hookah smokers: 6.43±0.50; non-smokers: 9.80±0.83;
P
<0.05). Endothelium-independent dilation of the brachial artery in response to sublingual nitroglycerin did not significantly differ between groups.

Conclusions:
Despite claims of safety advertised by the growing hookah tobacco industry, our findings provide evidence that, as compared to non-tobacco users, young and apparently healthy adults who regularly smoke flavored hookah tobacco exhibit reduced vascular endothelial function. These results suggest that flavored hookah tobacco smoking is not without harm and has potential harmful vascular effects, associated with increased cardiovascular disease risk.
Abstract 3145: Inactivating The Adenosine 2A Receptor Reduces Vascular Calcification Through Modulating Osteogenic Differentiation Of Vascular Cells
Authors: Zhao Dingwei , Zhou Yaqi , Ma Qian , Cai Yongfeng , Yang Qiuhua , Huo Yuqing
Published: July 2024

Background and Aims:
Vascular calcification (VC), a major contributor to cardiovascular morbidity and mortality particularly in patients with diabetes and chronic kidney disease (CKD), is an active cell-driven process involving osteogenic differentiation of vascular cells. Adenosine 2A receptor (ADORA2A) is highly expressed in vascular cells and associated with coronary artery disease; its role in VC remains unclear. This study aims to investigate the effects of ADORA2A on VC and evaluate whether ADORA2A is a potential therapeutic target for VC.

Methods:
Cultured vascular cells and mouse aortas were treated with osteogenic medium (OM) to establish
in vitro
and
ex vivo
models. VC in mice was induced by a combination of 5/6
th
nephrectomy, a high phosphate diet, and a vitamin D supplement. The effects of ADORA2A on vascular calcification were evaluated by calcium deposition, alkaline phosphatase activity, and changes of osteogenic markers and vascular phenotypic markers.

Results:
ADORA2A expression was upregulated in OM-treated vascular cells and aortas, aortas of CKD mice, and calcified tibial arteries of patients. Mice with
Adora2a
global or vascular-specific deficiency or treatment with an ADORA2A pharmacological antagonist displayed attenuated calcium deposition and decreased expression of osteogenic markers in calcified aortas. The same findings were observed in
in vitro
and
ex vivo
assays. Mechanistically, ADORA2A-mediated osteogenic differentiation in vascular cells was mediated by hypoxia-inducible factor-1A (HIF1A).

Conclusion:
ADORA2A inactivation mitigates osteogenic differentiation of vascular cells and aortic calcification by downregulating HIF1A activation; therefore, blocking ADORA2A holds promise for treating VC.
Relationship of volitional regulation and lifestyle of Tuva residents living in rural vs urban areas
Authors: Shlyapnikov Vladimir N.
Published: July 2024

Background. The paper presents the results of research into the features of volitional regulation among Tuvans living in rural areas and cities. Objectives. The study had its purpose to test the hypothesis about the relationship of volitional regulation with the characteristics of the lifestyle and semantic sphere of the respondents. Methods: “Action Control Scale”, “Questionnaire for identifying the severity of self-control in the emotional sphere, activity, and behavior”, PIL test, and the author's ad hoc questionnaire for studying the lifestyle characteristics. Sample. Tuvans living in Erzin (185 people), in Mugur-Aksy (265 people), in Kyzyl (172 people), and in Moscow (105 people) were compared. In total, the study involved 727 people aged 18 to 79 years, 466 women and 261 men. Results. It is shown that Tuvans living in rural vs urban areas assess their lifestyle differently. Rural residents are significantly more likely (p = 0.01) to assess their way of life as traditional whereas urban residents consider their lifestyle as modern (p = 0.01). MANOVA revealed the significant differences between the compared groups in all indicators of volitional regulation. Сovariance analysis showed that these differences are due to the lifestyle characteristics as well as the features of the respondents’ semantic sphere. The data processing obtained significant effects of the PIL test indicators and lifestyle characteristics for the Action Control Scale (p = 0.01 and p = 0.05, respectively), for emotional self-control (p = 0.01 and p = 0.01), behavioral self-control (p = 0.01 and p = 0.01), and social self-control (p = 0.01 and p = 0.01). Conclusion. The obtained results allow to assume that in the process of modernization/urbanization of Tuvan society, the role of traditions and group experience in the regulation of activity decreases whereas the role of volitional regulation increases.
Model of actor’s psychophysical actions based on Leontiev's activity theory
Authors: Mashkov Vladimir L.
Published: July 2024

Background. Dramatic art requires methodological foundations to be applied for training; psychological theories can form the basis for actor’s skills and allow for the conscious control of performing activities. Nowadays the realistic approach to theatrical art (Stanislavsky, K.S., Toporkov, V.O.) based on the idea of the life-like verisimilitude of acting does not lose its relevance, however, its terms and methods require correlation with psychological constructs describing the structure of actor play as a type of activity. Objective. Development of model ideas about the structure of an actor’s psychophysical actions by correlating the psychological structure of activity as per A.N. Leontiev with the system of acting work presented in the approaches of K.S. Stanislavsky, V.O. Toporkov. Methods. A systematic analysis of domestic and foreign research on the psychological structure of activity (A.N. Leontiev, L.S. Vygotsky, K. Levin, B.V. Zeigarnik, W. James, S. Shekhter, etc.) allowed to apply A.N. Leontiev’s theory of activity to the methods of acting presented in the works of the famous theater directors (K.S. Stanislavsky, V.O. Toporkov, M.A. Chekhov, V.E. Meyerhold, E.B. Vakhtangov, etc.). Results. It is shown that external and internal sides of the actor’s psychophysical action have the same psychological structure: activity (reconstruction of realistic human behavior) — motivation (“supertask”, character’s “struggle”), action (psychophysical action) — goal (representation of the final result related to “supertask”), operation — conditions (given circumstances). The permanency and controllability of the actor’s psychophysical actions is ensured by motivational structures (motive, goal), and not by emotions, which lack incentive effect and duration. Experience arises naturally while acting in the given circumstances motivated by goals and supertask. Conclusion. Understanding the structure of activity and its motivational aspect allows to control the actor’s psychophysical action through conscious goal setting and managing its achievement. Psychophysical actions cannot be performed beyond the given circumstances and represent a synthesis of the first and second signaling systems.
Personal regulators for building the image of the future at different stages of professionalization
Authors: Saporovskaya Maria V. , Konzhin Sergei I. , Tikhomirova Elena V. , Samokhvalova Anna G.
Published: July 2024

Background. In today's rapidly changing world, it is extremely important to maintain one's own trajectory in relation to life goals, the image of the future at different stages of professionalization. In this regard, it is relevant to determine personal regulators that allow for conscious and purposeful influencing the achievement of the expected future and their change in the process of professionalization. Objective. The study had its purpose to investigate the image of the future, its characteristics (completeness, clarity, time perspective), functions and personal regulators (self-regulation, coping behavior and life orientations) at different stages of professionalization. Methods. The study implemented quantitative methods: a basic questionnaire by V.I. Morosanova "Style of self-regulation of behavior - SSPM", 2015; “Time Perspective Questionnaire” (F. Zimbardo, 1997) adapted by A. Syrtsova, 2007; "Test of Life-Meaning Orientations" (Crumbaugh, Maholick, 1964) adapted by D.A. Leontiev, 2000; methodology "WCQ – Ways of Coping Questionnaire" (R. Lazarus and S. Folkman, 1985) adapted by T.L. Kryukova, E.V. Kuftyak, M.S. Zamyshlyaeva, 2004. And qualitative methods: the method “Unfinished Sentences” (Sachs, Levy, 1950) modified by the authors and metaphorical associative maps “Roads” (G. Salpeter, 2014) for which the author’s semi-standardized interview was developed (S.I. Konzhin, M.V. Saporovskaya, 2021). Sample. The study involved 184 people - men and women from 16 to 40 years old (M = 23.2; SD = 7.43) who gave informed consent to participate in it. The respondents were divided into three empirical groups: respondents at the stage of professional self-determination (aged 16-17); respondents at the stage of obtaining professional education (aged 18-25); respondents engaged in professional activities (aged 26-40). Results. The study revealed significant differences in the influence of self-regulation, coping behavior and life-meaning orientations on the time perspective of the future at different stages of professionalization. Content-analysis allowed to establish the structure, clarity, and completeness of the image of the future. Regression analysis indicated that “Locus of control-Self”, the coping strategy “Planning to solve a problem” and the regulatory-cognitive competence “Planning” make the greatest contribution to the regulation of the Future image of the respondents. Focus on the Future, the relevance of planning the Future image have certain differences and specifics at the different stages of professionalization. Conclusions. Locus of control, strategies of coping behavior and regulatory competencies can be considered as personal regulators of creating an image of the future at different stages of professionalization.
Value-semantic regulators and personal characteristics of emergency service operators with different length of work experience
Authors: Aldasheva Aigul A. , Pervacheva Olga A.
Published: July 2024

Background. Professional activity of the emergency service operators is directly related to the organization of assistance to people in trouble, which imposes great responsibility and special moral requirements on the specialists. Objective. To investigate the value-semantic regulators and their connection with personality features of emergency service operators with different length of work experience. Methods. The study implemented the following diagnostic techniques: the ad hoc questionnaire on the values of professional interaction; “Psychological appearance” questionnaire by E. Reznikov (three scales: values-goals, values-means and attitudes to work); “Self-Regulation Profile Questionnaire-98” by V. Morosanova; T. Leary’s “Diagnostics of Interpersonal Relations” adapted by L. Sobchik; S. Muddy’s “Resilience Test” adapted by D. Leontiev; “Method of assessing trust to one’s self” by N. Astanina; “Method of assessing trust/distrust to other people” by A. Kypreichenko; G. Herzberg’s “Motivation Structure Test”. Sample of the study included emergency service operators of the State Budgetary Institution “System 112” (N = 82) and was divided into 2 groups according to their lengths of work experience — “novices” (1 to 3 years) and “experienced professionals” (4 to 9 years). Results. Value-semantic regulators of the group of novices are “respect” and “goodwill”, reflecting the main orientation of this type of operator work. This group is characterized by the conjunction of responsible attitude to work and trust to one’s self. The main mechanisms of self-regulation of the “novices” are modeling and flexibility. A distinctive value of professional interaction in the group of experienced operators turned out to be “hard work”. Professionals in this group tend to take responsibility based on self-confidence and their style of self-regulation. This group is also characterized by high levels of resilience, risk acceptance, and self-control. Conclusion. For experienced operators of “System 112” emergency service, the basis for an individual style of professional activity that allows them to cope with emergency component is the value attached to work. The distinctive value-semantic regulator of this group is “hard work” performing a motivational function. The behavioral strategy of experienced emergency operators is reflected in the interconnection of “resilience,” “risk taking,” and “control.” The professional behavior strategy of the novices in emergency service is associated with their attitude to work based on the value of other people. The main value-semantic regulators of their professional interaction are “respect”, “help”, and “benevolence” performing an integrative function. Newcomers to the emergency service are characterized by an adaptive strategy, which is supported by such self-regulation mechanisms as “modeling” and “flexibility.” Their distinctive feature is a responsible attitude to work in conjunction with self-confidence and flexibility.
Individual and group interests of HR specialists as value-semantic regulators of their self-efficacy
Authors: Lobanova Tatiana N.
Published: July 2024

Background. In modern organizations, specialists who are ready to cope with uncertainty, stress, anxiety, capable of conscious self-regulation, self-organization, and characterized by high self-efficacy are of particular value. First of all, this applies to specialists who directly work with the personnel of organizations, since their effectiveness and motivation influence the activities of other employees. In this regard, it seems relevant to study individual and group interests of HR specialists as their self-efficacy regulators in the system of personal resources. Objective. The study had its purpose to study the relationship between the self-efficacy of HR-specialists and their individual and group interests. Methods. Theoretical categorical analysis, the Maddux-Scheer self-efficacy test, the author's technique for identifying the employees' labor interests, statistical methods. Sample. Human resource specialists, N=120, 67% women, mean age 31 years. Results. Analysis and comparative evaluation of the data obtained on 8 subscales of labor interests (economic, professional, career, group, corporate, territorial, civil and general) and 2 subscales of self-efficacy (activity and social) have revealed that HR-specialists with high and medium levels of self-efficacy were dominated by the individual (economic, professional, and career) interests, while those with a low level of self-efficacy – by the group and corporate interests. It was found that professional, career, and economic interests are most associated with self-efficacy (r=0.5; r=0.485 and r=0.423 with p` <0.05, respectively). The group interests of HR-specialists are not linked to their self-efficacy. Conclusion. The identified correlation between general labor interests and self-efficacy allows to conclude: the higher the level of interest of an HR specialist in his activities, the higher he assesses his competence in solving professional problems and the more confident he is in achieving the desired result, which strengthens his self-efficacy in professional activities and ultimately affects labor productivity. In addition, the orientation of labor interests can serve as a value-semantic regulator of self-efficacy.
Differential aspects of regulatory and personality resources of students with different profiles of school engagement
Authors: Potanina Anna M. , Morosanova Varvara I.
Published: July 2024

Background. Presented research was carried out in the context of relevant in modern psychology differential approach to the study of the psychological characteristics ensuring students’ academic achievement. Objective. The study had its purpose to identify differential features of regulatory and personality resources of academic performance in the students with different profiles of school engagement. Sample. The sample consisted of 1056 schoolchildren of 5-11 grades. Methods. V.I. Morosanova’s “The Self-Regulation Profile of Learning Activity Questionnaire (SRPLAQ)”; “A Multidimensional School Engagement Scale” (Wang et al., 2019; Russian adaptation Fomina, Morosanova, 2020); “Big Five Questionnaire — Children version (BFQ-C)” (Russian adaptation Malykh et al., 2015); “Academic Motivation Scale - School (AMS-S)” (Gordeeva et al., 2017); “Attitude towards learning in middle and high school” (modification of «Method of diagnostic of learning motivation and emotional attitude to learning in secondary and high school») (Andreeva, Prikhozhan, 2006). Academic achievement indicator was calculated as the average score in all subjects. Results. The study revealed 4 groups with different levels of school engagement and its components. An analysis of differences in achievement resources in the identified groups showed that students with a high level of school engagement were characterized by the highest levels of self-regulation, internal academic motivation, extraversion, conscientiousness and openness to experience. The most successful in terms of academic achievement were the students with a high level of all engagement components, as well as those with a high cognitive engagement. Conclusion. The study provides empirical data on the differential features of regulatory and personality resources of academic achievement in the students with different profiles of school engagement. Further studies might be aimed at investigating the age specificity of the identified engagement profiles and individual typological features of academic achievement resources.
The role of behavior control in academic achievement and social competence of younger schoolchildren
Authors: Vilenskaya Galina A.
Published: July 2024

Background. Self-regulation ability plays an important role in the school success of children — their academic performance and social competence. However, little is known about the specific aspects of self-regulation contributing to this or that competence. Purpose. The study had its purpose to reveal the contribution of behavior control as a subjective regulatory function to the progress of younger schoolchildren and their social competence. Methods: BRIEF questionnaire to assess behavior control, sociometry to assess social competence, additionally — a questionnaire for teachers to reveal the teacher's attitude towards the child as a factor that can also influence the variables under study. Sample. 75 children 9–10 years old, 34 are girls, students of grades 3–4. Results. Regression analysis showed that behavior control contributes to academic performance (R2 = 0.341, p = 0.022 for the Russian language; R2 = 0.425, p = 0.006 for mathematics). The teacher’s assessment of the child’s popularity also predicts academic performance (β = 0.588 for the Russian language and β = 0.623 for mathematics). Apart from that, behavior control predicts the likelihood of a child being accepted by peers (R2 = 0.260, p = 0.028). And, additionally, schoolchildren's acceptance is predicted by their academic performance. Conclusions. The study revealed significant contribution of behavior control to the academic success and social competence of the younger schoolchildren. Further work will be focused on clarifying the role of emotional control and initiative of a child in the academic performance and social competence of the primary school students.
Body schema and the system of mental representation of human movements
Authors: Polikanova Irina S.
Published: July 2024

Background. The study of mental representations of the human body has more than a century history. Although quite a lot of knowledge and research results have already been accumulated, there is still no common understanding of the body schema and body image. Despite the importance of the internal representation system for the formation and implementation of body movements, in the Russian-language literature very few works are devoted to this issue. Objective. The study had its purpose to systematize and analyze data on the body schema and body image as systems of internal representation of human movements. Results. The literature analysis showed that most researchers agree that body schema and body image are different non-identical phenomena and that body schema, or at least its parts, is innate. In the course of life, body schema plays a crucial role in the implementation of body movements, including through feedback, integration of sensorimotor experience and multimodal sensations. At the same time, the body image cannot be considered in isolation from the body schema. It is formed mainly on the basis of integration of various types of stimulation (tactile, vestibular, proprioceptive, visual, etc.). In the context of studying movement formation, proprioception and vestibular reception also play a critical role. Thus, in case of the proprioception loss, the body image suffers first of all, which leads to impossibility of automatic performance of even simple movements. However, there is still a possibility to realize the motor function on the basis of the body schema. Conclusion. Body schema, being initially innate, is a relatively independent phenomenon, which is gradually adjusted, refined and perfected in the course of life, growth, and accumulation of individual experience (motor, sensory, vestibular, proprioceptive, etc.). Body image is predominantly formed during one’s life on the basis of integration of information from proprioception, multimodal receptors, sensorimotor stimulation, and feedback.
Relationships of value orientations and satisfaction of safety needs with attitudes towards robots among people of different generations
Authors: Saenko Alexsey Y.
Published: July 2024

Background. Attitudes towards new technologies are interconnected with various psychological factors, including the personal value profile. One of these technologies is a robot equipped with artificial intelligence, which can sometimes be perceived as a source of threat, including psychological safety. Meanwhile, the problem of the relationship between the value profile, security needs satisfaction and the attitude towards robots among representatives of different generations remains insufficiently studied. Objective. To conduct a pilot study on the relationships of the value orientations and security needs satisfaction with the attitude towards robots among people of three generations of Russian people: X, Y, Z. Study Participants. The study sample consisted of 102 people aged 18 to 55 years (residents of Moscow and Moscow region), generation X — 29 people (born in 1968–1981), generation Y — 38 people (born in 1982–2000), generation Z — 35 people (born since 2001 and later). Methods. “Portrait Value Questionnaire” (PVQ-21) by S. Schwartz, questionnaire “Assessment of security need satisfaction” by O. Zotova, “Attitude towards technology” questionnaire by G. Soldatova et al., “Negative Attitude towards Robots Scale” (NARS) adapted by V. Akmayev. Results. The study has identified significant differences in the value profile, security need satisfaction, and attitudes to technology among representatives of generations X, Y, and Z. The data analysis showed partial shift in the system of values and security satisfaction degree from generation X to generation Z. Thus, the older generation X is characterized by a desire for traditional things, as well as a lower level of security need satisfaction, which correlates with a more negative attitude towards robots. Whereas the younger generation Z, being more risk-averse, has a more positive attitude towards robots. The regression analysis has identified the predictors of negative attitudes towards robots. Conclusion. The study highlights the existing relationships between a person’s attitude towards robots, security need satisfaction and the value profile, which has characteristic differences in certain age groups. A high degree of security need satisfaction is a predictor of positive attitudes towards robots. New technologies can contribute to a sense of insecurity which is consistent with a lack of accepting them. Thus, the study revealed certain differences in attitudes towards robots among representatives of different generations. There is a need for maintaining an optimal level of psychological safety in order to form a positive attitude towards new technologies including artificial intelligence.
Illness representations in patients with acute leukemia and lymphoma: a comparative study
Authors: Esina Liubov V. , Vybornykh Dmitry E. , Rasskazova Elena I. , Gemdzhian Eduard G. , Zvonkov Еvgeny Е. , Lukyanova Irina A. , Moiseeva Tatyana N. , Magomedova Aminat U.
Published: July 2024

Background. Illness representations determine a patient's successful adaptation in the context of chronic somatic illness. Objective. The study had its purpose to investigate and compare the illness representations in the patients with acute leukemia and lymphoma. Study Participants. The study involved 109 respondents: 51 patients with acute leukemia aged 18 to 64 years (Mage = 35.12; SD = 12.90; 28 women) and 58 patients with lymphoma aged 19 to 64 years (Mage = 42.22; SD = 11.17; 41 women). Methods. The study implemented the following methods: “Illness Perception Questionnaire-Revised” (IPQ-R), “Health Anxiety Inventory” (HAI), “Cognitions About Body and Health Questionnaire” (CABAH), and the “Scale of Assessment of Illness Behavior” (SAIB). Descriptive statistics and group comparison methods (Student's t-test) were used to process quantitative data. Results. A comparative analysis of the data obtained showed that patients with acute leukemia have more difficulty in identifying the disease, were more certain about the negative impact of the disease and its unstable course, were more likely to overestimate symptom severity, and paid more attention to implementing treatment- and medication-related behaviors compared to patients with lymphomas. Conclusion. The main targets of psychological work with patients with acute leukemia are their ideas about the disease identity, its unstable course and negative consequences, their tendency to overestimate the symptom severity and underestimate the importance of preventive behavior associated with treatment and medication. Common targets of psychological work with patients with acute leukemia and lymphoma are their ideas about the short-term course of the disease and negative emotional experiences about their disease.
Actualization of giftedness: activity and contemplation
Authors: Melik-Pashaev Alexander A.
Published: July 2024

Background. The article is devoted to the interaction of different yet inseparable “poles” — activ-ity and contemplation — in the process of actualization of a person’s creative potential. It has been shown that both recent psychological studies of giftedness and pedagogical practice demonstrate a disbalance of the two poles in favor of activity, although activity obtains creative qualities precise-ly because it takes a source in the experience of contemplation. Objective. The study had its purpose to substantiate the significance of the contemplation phe-nomenon and outline possible ways of developing this ability. Results. The author briefly deals with the history of the very problem of contemplation in the con-text of culture, in religious practices, and in psychology. The analysis revealed the difficulty of studying the contemplation by means of traditional scientific methods since a meaningful descrip-tion of this phenomenon by an observer becomes understandable and convincing for another per-son only if they have a similar personal experience. Contemplation is associated with liberation from the limitations of the everyday “ego” and with the experience of unity with the world, due to which the birth of creative ideas becomes possible. Special attention is paid to the contemplative aesthetic attitude towards the world, which underlies artistic creativity and the development of human artistic talent. It is due to this kind of attitude that ideas are born demanding their embodi-ment in the activity, which acquires a creative character exactly for this reason. Conclusion. Pedagogy, entirely focused on the translation of methods for mastering a particular activity, does not naturally lead to the development of a person’s creative talent and can even hin-der this by swapping the goals and means of work in art, as in any other field of creative activity.
Reflexive projecting resource for personal and professional development of educational psychologists: psychological content and conditions of actualization
Authors: Vostokova Julia I.
Published: July 2024

Background. The modern education system needs psychological tools that allow to transform the potential capabilities of specialists who directly provide and accompany the educational process (teachers, educational psychologists) into the resources of their personal and professional development. Objectives. The study had its purpose to investigate the psychological content of reflexive projecting as a resource for personal and professional development and to identify the technological conditions for its actualization. Study Participants. The study involved 292 students of the Arzamas Branch of Nizhny Novgorod State University in the field of “Psychological and pedagogical education” aged 17 to 24 years. Methods. Shostrom’s Self-actualization test (SAT) adapted by Alyoshina, Gozman et al.; Karpov's Reflexivity questionnaire; Self-attitude questionnaire by Stolin & Pantileev; Self-esteem assessment by Dembo & Rubinstein; Rotter's “Locus of Control Test” adapted by Bazhin et al.; “Personality differential” (a variant adapted at the V.M. Bekhterev Research Institute); Activity self-organization questionnaire by Mandrikova. Dispersion, factorial, and multiple regression analyses were used for the data processing. Results. The data analysis established that the psychological content of the reflexive projecting resource consists of five factors — “general level of self-attitude”, “self-organization”, “conscious readiness for transformation”, “self-assessment”, “self-immersion”. The study revealed positive interrelations of these factors with the integral characteristics of personal and professional development. The longitudinal experiment demonstrated the effectiveness of the developed technology for actualizing the reflexive projecting resource. Conclusions. The psychological conditions for the actualization of reflexive projecting as a resource for personal and professional development include the formation of a positive self-attitude, high self-organization and self-assessment, conscious readiness for transformation, striving for self-development (internal conditions) and integration of the technology of reflexive resource determination of educational psychologists into the training process of the university (external conditions).
Personal and professional development of teachers as a factor in realizing the potential of the underachieving gifted schoolchildren
Authors: Scheblanova Elena I.
Published: July 2024

Background. The study of personal characteristics and cognitive needs of the intellectually gifted students with underachievement in school is relevant for the scientific substantiation of the personal and professional development programs and training for the teachers to interact with such pupils. Objective. Theoretical and methodological analysis of new scientific data on the cognitive and personal development of intellectually gifted schoolchildren underachieving in education as the psychological and pedagogical basis for developing teacher training for interaction with such students; empirical study of motivational and personal characteristics of intellectually gifted schoolchildren with different academic achievement. Study Participants. The empirical study involved 460 intellectually gifted students in grades 5–10 in Moscow schools, 74–80 people in each cohort. Methods. Theoretical and analytical review of new scientific publications on the peculiarities of the cognitive and personal development of intellectually gifted schoolchildren underachieving in education as well as their psychological and pedagogical support by teachers. The empirical study implemented the diagnostics complex including tests of cognitive abilities, questionnaires of achievement motivation, academic and general self-esteem (adapted by the author: Shcheblanova, 2006), parametric statistical methods for the data processing. Results. The analysis of the school teachers' ideas about self-efficacy in teaching gifted students demonstrated their insufficient professional readiness to work with such pupils. Recent scientific publications review highlighted the important aspects of the modern understanding on differentiated approach to the identification and education of intellectually gifted children taking into consideration the new data on the variability of giftedness manifestations and trajectories of its development in the programs for the personal and professional development of teachers. Conclusions. The study provides theoretically and empirically substantiated basis for developing teacher professional and personal training for effective interaction with intellectually gifted students, and namely, — understanding the peculiarities of not only cognitive, but also motivational and personal development of students with high abilities and varying academic achievement as well as the need of psychological and pedagogical support for intellectually gifted underachievers.