bluuebunny/crossref_metadata_2025 huggingface dataset:
Apuntes sobre “¿Por qué a la Filosofía Analítica le importa el Lenguaje?"
Authors: Fonseca Martínez Miguel
Published: October 2024

Las ideas acerca del lenguaje son el núcleo de la tradición del análisis filosófico. Cierta unidad en esta tendencia proviene de la propuesta según la cual el uso agota el significado. Tal afirmación, no presente con tanta preeminencia en el primer periodo de la filosofía analítica, se emparenta con una visión deflacionaria de la filosofía y sus problemas. Así, los estados intencionales deben ser explicados en virtud de las reglas de uso del lenguaje. En este sentido, como se puede apreciar, Skorupski asume como punto de partida a su reflexión, la propuesta de Dummett denominada tesis de la prioridad (Dummett, 1993). El autor pretende demostrar en su trabajo que la tesis de la prioridad, basada en la noción de que todo contenido cognitivo es fáctico y que la interpretación del significado debe ser entendida como uso, fracasa.
Agencia eidética y causalidad
Authors: Fonseca Martínez Miguel
Published: October 2024

A partir de los fundamentos de la propuesta de una agencia eidética (Fonseca, 2020) que consiste en un modelo en torno a la teoría de la acción, que asume una visión extensiva y andamiada de nuestro sistema epistémico y su normatividad, la ponencia pretende mostrar a la causalidad como una aplicación filosófica de modelos formales de razonamiento. Siguiendo los postulados de Hume (1748), Lewis (1973) Halpern y Pearl (2005) y principalmente de Spohn (2012), se planteará el argumento, según el cual, la causalidad es un modelo eidético de razonamiento y agencia.
El gobierno de las cooperativas y asociaciones de los conocimientos tradicionales en Colombia en estado de crisis
Authors: Fuentes Mancipe Mónica María , Ángel Guarnizo Luz Karime
Published: October 2024

En los últimos años en Colombia las comunidades indígenas, étnicas y campesinas han optado por la creación de cooperativas y asociaciones, con el propósito de formalizar la propia economia, centrada en la venta de productos artesanales y agroindustriales, persiguiendo ademas la tutela de los conocimientos tradicionales que permiten resguardar la pluralidad cultural.
La clausula de la nación más favorecida y su visión sui generis en los tratados de inversión
Authors: Fuentes Mancipe Mónica María
Published: October 2024

Este Articulo tiene como propósito realizar estudio de las cláusulas "Cláusula de Nación Más Favorecida", más conocida como NMF en un contexto internacional a partir de su noción general, conceptualización e interpretación de la en los tratados de inversión. Por lo tanto, en el curso de este trabajo, primero se ilustrará su contexto histórico y luego el análisis de la cláusula NMF y su interpretación por los distintos tribunales internacionales.
Some Thoughts on the Development of Contemporary
Art in the Context of Artificial Intelligence
Authors: Chen Hanyi
Published: October 2024

The development of contemporary art has enabled traditional artistic expressions such as painting, photography, and sculpture to
gradually break the rigid mode under the traditional ideology, develop different forms and contents, and gradually expand the artist's
understanding of the essence of art. What art creates is not the ice-cold presentation of artworks, but rather, the powerful conveyance of
the artist's personal value. The development of artificial intelligence(AI) in the field of art has attracted an increasing amount of attention.
However, we should analyze new things like the AI art dialectically.
Strategies to Create a Climate of Change Readiness in Organizations
Authors: Yang Bin
Published: October 2024

The purpose of this article is to investigate how to create a positive climate for change readiness in organizations from the perspective of managers. This paper explores the literatures and researches about organization change. It advances understanding of change readiness by considering its characteristics. Change readiness is critical to change implementing and organization success, organizations should adopt effective strategies to create a climate for it.
The Application of Formative Assessment
to Primary School English Teaching
Authors: Wang Ailing
Published: October 2024

With the deepening of the new curriculum reform, the pursuit of the quality of primary school English classroom teaching is the
teaching goal of every English teacher. In order to improve the quality of English teaching, teachers not only need to innovate teaching
methods and change teaching concepts, but also need to attach great importance to effective teaching evaluation. Teaching evaluation is an
indispensable part of teaching activities, and a scientific evaluation system is a powerful guarantee for achieving teaching goals. This article
mainly introduces the application of formative evaluation in primary school English teaching, the significance of formative evaluation and
the problems that should be paid attention to in the application process, so as to help primary school English teachers fully understand and
use formative evaluation to evaluate primary school students. English learning stimulates students' interest in learning English and improves
the level of English teaching in primary schools.
Innovation Analysis of Higher Vocational Education Management Model under the Background of Informatization
Authors: Li Baojing
Published: October 2024

Information resources bring development opportunities to school education and enrich education management models. Vocational
college teachers should have a clear understanding of the main challenges faced in the education management model in the informatization
environment, be aware of the important significance of implementing the informatization education management model, and adopt a series of
effective solutions to promote the rational use of information. Enhance the supervision effect of education management models.
Analysis of the Relationship between Environmental Monitoring and Environmental Impact Assessment
Authors: Li Mei
Published: October 2024

The strategy of sustainable development in our country puts forward higher requirements for the development of our environmental protection work, at the same time, environmental monitoring is the main content of the work, which has a very positive effect on our ecological environment. This paper briefly analyzes the relationship between environmental monitoring and environmental impact assessment, to provide reference.
A Study on the Continued Use of KnowledgeBased APP Users in Guizhou Based on the
Perspective of Perceived Value
Authors: Yang Shengxia
Published: October 2024

The wide variety of products offered by online sales platforms makes choosing the correct item a challenging task. The expertise and
knowledge of customers in such product assortments can vary widely. Therefore, there is a need for intelligent recommender systems that
provide personalized dialogues that support customers during the product selection process. The three research objectives are: to explore
the factors in continuing for using knowledge-based apps; to identify the relationship between influencing factors and sustainable usage
intention; to search for the countermeasures and suggestions for the continued development of applications user policies.
Research on Hospital Archive Management from the
Perspective of Public Administration
Authors: Huang Xiaoqian
Published: October 2024

This paper explores the transformation of hospital archive management from a public administration perspective, emphasizing the
shift towards an open model and public administration paradigm. By analyzing the concepts of publicness, service-orientedness, and collaborative governance, it proposes new management ideas of public responsibility, comprehensive development, and fair service. It also introduces practical paradigms such as document integration, resource management, and public participation, as well as implementation paths for
enhancing awareness, institutional construction, cultural creation, and mechanism improvement. The aim is to promote the modernization of
hospital archive management through the combination of theory and practice, efficiently serving society and public health.
Research on Quality Control and Problems
of Food Inspection and Testing
Authors: Li Feng
Published: October 2024

At present, the food quality inspection industry has become an important foundation of the national quality development strategy.
Combined with China's current food inspection and testing work to implement the status quo analysis, there are still problems in the
development stage, the need to grasp the actual situation based on the factors affecting the targeted solution to ensure that the food
inspection and testing of the work of the importance of the need for a strong.
Study on the Reservoir Characteristics of the Triassic
Yanchang Formation in the Majiahe Area, Ordos Basin
Authors: Ji Jiadong , Wang Guicheng
Published: October 2024

This study thoroughly analyzes the petrological and physical properties of the Chang 4+5 and Chang 6 reservoirs of the Triassic
Yanchang Formation in the Majiahe area of the Ordos Basin. The lithology in the study area is mainly composed of gray fine-grained feld-spathic sandstone, followed by medium to fine-grained and silt to fine-grained feldspathic sandstone. The overall petrological characteristics
indicate low compositional maturity and high structural maturity, reflecting the complexity of the depositional environment. The reservoir
properties exhibit extremely low porosity (very low to ultra-low porosity) and permeability (very low to ultra-low permeability), with significant heterogeneity in the reservoirs.
Construction and Development Strategy of General Medicine in Hospitals
Authors: Lv Yanping
Published: October 2024

This paper starts from the necessity and importance of the construction of general medical department in medical institutions, puts forward the basic ideas and strategies for the construction and development of general medical department in medical institutions, and briefly discusses the content of its construction.
A Short Study on the Constructing Mechanism of Basic Education Community
Authors: Huang Qiming
Published: October 2024

The importance and urgency on the constructions of Basic Education Community originate from the needs of the balanced developments of basic education, the realizations of the Educational Internationalization and the healthy promotions of the Belt and Road Initiative.
Social Interaction Theory, Educational Governance Theory and Educational Ecosystem Theory have played positive leading roles in the constructions of basic education communities. The governments, schools, families, communities, other educational actors and some organizations
or institutions in the society who are involved in the constructions of the basic education communities ought to be burdened with their own
responsibilities and obligations under the guidance of these theories.
Şîîra Moderne Ya Kırmanckî (Zazakî) De Wuslat Û Fîraq
Authors: Yıldız Pınar
Published: October 2024

Na xebate de ma do hewl bidê ke mefhûmê “wuslat û fîraq”î yo ke morê xo dayo şîîra rojawanî ro, şîîra moderne ya kirmanckî (zazakî) ser o senîn hewa tesîr kerdo, ey ser o vinderê. Şîîra zazakî de temayê ke zaf zêde ameyê şuxulnayene meseleyê komelkîyî, exlaqîyî û eşq o. Bîlhesa temaya eşqî şîîra moderne ya zazakî de zaf zêde ameya şuxulnayene. Nê ra zî girêdaye mefhûmê “wuslat û fîraq”î zî nê şîîran de, goreyê terz û uslûbê nuştoxan ameyo şuxulnayene. Çike edebîyatê rojhelatî de, manzûman; cîyabîyayîş û dûrîmendişê aşiq û maşûqî ra hêz girewto. No cîyabîyayîş yeno yew merhele ke şaîr (aşiq), mîyanê dejê cîyamendişî de hende vindî beno ke êdî nêwazeno bireso “waştîya xo.” Edebîyatê tesewufî de mefhûmê “wuslat û fîraq”î eşqê îlahîyî temsîl keno. Nê ewnîyayîşî de pêresayîş çîyêko bêîmkan o. Coka “wuslat û fîraq” yew rayero dûr û zehmetin o ke hem derdê cîyamendişî tede est o hem zî layîqê a roja pêresayîşî bîyayîş zaf muhîm o. Şîîrê zafê şaîranê kirmancan de ma derd, keder û îsyanê cîyabîyayîşî vînenê ke şaîrî bi bêîmkanîya xoresnayîşê waştîye nalenê. Şîîra moderne ya zazakî de zafane wuslat û fîraq seba eşqê fanîyî ameyo qestkerdene yanî nê şîîran de qestêko tesewufî çin o. La reyna zî goreyê terzê nuştoxan mefhûmê wuslat û fîraqî eşqîno bibedilîyo.
Arap Edebiyatında Gazel Şiirleri ve Bu Şiirlerin Beşeri Aşkın Yanında Tarihi Süreç İçinde İlahi Aşk Mefhumunu Konu Edinmesi
Authors: Abdülhadioğlu Ahmet
Published: October 2024

Arap edebiyat tarihinde İslam öncesi dönemde klasik tarzdaki kasidelerin bir unsuru olarak şiirlerde yer alan gazel, sevgiliden, sevgiliye duyulan özlemden, kalıntılardan ve aşk acısından bahseden bir tür olarak karşımıza çıkmaktadır. İslami dönemle birlikte İslami esaslara aykırı düşmesi sebebiyle bu tür şiirler yasaklanmış, toplumsal ve kültürel sebeplerle gerilemiştir. Emeviler dönemiyle birlikte uzri gazel yanında sarih gazel müstakil bir tür olarak karşımıza çıkmaktadır. Abbasiler döneminde ise beşeri aşkın yanında ilahi aşk konusunu işleyen gazel türü ortaya çıkmıştır. Bu tür şiirlerin en önemli temsilcileri arasında sade diliyle bilinen ve Allah’a ulaşmanın yollarını şiirlerinde işleyen Râbiatu’l-Adeviyye ile daha çok felsefi ve sembolik bir dil kullanmayı tercih eden İbnu’l-Fârid gelir. Bu çalışmada, tarihi süreç içinde gazel şiirinin ortaya çıkışı, gelişimi ve farklı bir tür olarak müstakil hale gelmesine değinilecek, bunun yanında sözünü ettiğimiz şairlerin ilahi aşk konusundaki görüş ve düşüncelerine şiirleri üzerinden yer verilecektir.
Investigation on the effect of age and gender variables on SARS-CoV-2 in persons applying to a hospital in İstanbul
Authors: Şener Devran , Kolören Zeynep , Karaman Ülkü , Kaşko Arıcı Yeliz
Published: October 2024

Objective: The study was planned based on the demographic characteristics (age and gender) of 36704 people who applied to a hospital in the Istanbul European region with the suspicion of COVID-19.
Method: Nasopharyngeal and oropharyngeal swab samples were taken from people who applied to the hospital between November 2020 and March 2021, and the detection of the SARS-CoV-2 virus was made by RT-qPCR technique. The data were evaluated with chi-square analysis and SPSS 28 statistical program was used in all calculations. Using the COVID-19 data in the first, middle, and last five days of the specified months, observing the course of the pandemic in this period was desired.
Results: It was found that the most COVID-19 PCR test was performed in November 2020 with 13380 (36.4%) cases and 2347 of the cases were detected as positive. It was observed that 4231 (11.5%) of the total cases (36704) were positive in all of the mentioned months. The highest number of positive cases is between the ages of 20-39 with 1995 people (47.1%). The following 1442 (34.8%) cases were reported to be between the ages of 40-59. While the distribution of COVID-19-positivepatients by age groups in November 2020 did not differ significantly between men and women, significant differences were found in December. The distribution of Covid-19 COVID-19 positive patients by age groups in 2020 and 2021 showed a significant difference. While the proportion of patients aged 0-9, 20-39, and over 60 was higher in 2020, the proportion of patients aged 10-19 and 40-59 was higher in 2021.
Conclusion: The effect of age and gender factors in the pandemic triage of individuals during the pandemic period when they were exposed to the COVID-19 epidemic was investigated retrospectively. No application has been made to harm the private information of the patients. The study is thought to contribute to detecting the SARS-CoV-2 virus, detecting pandemics and epidemics, and managing treatment, especially depending on age and gender.
The Effectiveness of Physical Therapy and Rehabilitation Approaches in Low Back Pain on Pain Severity and Disability; A Systematic Review
Authors: Dal Cansu , Bayar Banu
Published: October 2024

The objective of this study was to review the efficacy of physical therapy and rehabilitation approaches for low back pain, focusing on pain intensity and disability.
A survey of the literature was done in PubMed and Web of Science databases up to January 30, 2024. English studies were required, using keywords: “low back pain,” “pain intensity,” “pain severity,” “disability,” and “physical therapy.” Pain intensity was measured using the Visual Analog Scale and Numeric Rating Scale, including the 11-point Pain Intensity Numerical Rating Scale. Disability was assessed using Activities of Daily Living, Instrumental Activities of Daily Living scales, Roland Morris Disability Questionnaire, and Oswestry Disability Index. Seven studies met the inclusion criteria from 665 initial records. Interventions included osteopathic manipulative treatment, core muscle exercise with interferential current, cognitive functional therapy, dry cupping therapy, high-intensity machine-based core muscle resistance training,heat therapy, transcutaneous electrical nerve stimulation, pelvic traction, Reiki, dynamic muscular stabilization technique, and McGill Big 3. Sample sizes ranged from 30 to 1090 participants. Interferential current combined with core muscle exercises significantly reduced pain intensity compared to each method alone, though not statistically significant (p > 0.05). The high-intensity machine-based core muscle resistance training program group had greater pain relief (P0.05). Dry cupping did not outperform sham cupping. Cognitive functional therapy reduced absenteeism in the first two years but not later. Reiki showed significant improvement in pain and Activities of Daily Living compared to drug therapy, but not to physiotherapy. Physical therapy interventions effectively alleviate symptoms and enhance results for low back pain. However, variability in interventions and outcome measures necessitates cautious interpretation. Further research with standardized protocols is essential to understand the effectiveness and optimal duration of physical therapy for Low Back Pain.
Relação entre o conteúdo estimado de polifenóis e o grau de processamento dos alimentos oferecidos em restaurantes populares
Authors: Bubolz Caren Taiane Radtke , Helbig Elizabete
Published: October 2024

Objetivo: Investigar a oferta de polifenóis em alimentos oferecidos no cardápio de restaurantes populares do Sul do Brasil e relacionar com o grau de processamento. Método: Foram avaliados quantitativamente cardápios de dois Restaurantes Populares do Rio Grande do Sul por meio de cardápios disponibilizados por nutricionistas. Os cardápios foram desmembrados visando a identificação dos ingredientes. Os polifenóis foram estimados por meio do banco de dados online Phenol-Explorer 3.6. A análise do grau de processamento dos alimentos foi realizada com o auxílio do Guia Alimentar para a População Brasileira e da classificação dos alimentos NOVA, em quatro grupos. Para comparação entre os restaurantes e subclasses de polifenóis, foi utilizado o teste não paramétrico de Kruskal Wallis, com significância (p<0,05). Foi realizado um gráfico em série para descrever a oferta de polifenóis de acordo com o cardápio diário. Uma matriz de correlação de Pearson foi construída para avaliar a correlação existente entre as variáveis das subclasses de polifenóis, o teste T foi utilizado para avaliar a significância. Resultados: Foram analisados 103 dias de cardápios de dois restaurantes populares do Rio Grande do Sul. A média (proporção) de oferta nos restaurantes foi de 966 mg/almoço para polifenol total. A oferta média de alimentos in natura, ingredientes culinários, alimentos processados e alimentos ultraprocessados foi, respectivamente, 37,82%; 53,04%; 5,08% e 2,34%. Nos dias em que o cardápio apresentava alimentos ultraprocessados em maior quantidade, havia redução da oferta de polifenóis. Conclusão: Observou-se uma correlação entre o grau de processamento e o teor de polifenóis presentes.
Risk Analysis of Work Posture and Body Mass Index to Musculoskeletal Disorders among Librarians at Universitas Airlangga
Authors: Nugraha Adellian , Widajati Noeroel , Guan Ng Yee , Febriyanto Eka Cahya , Oktavia Nurul Dewi
Published: October 2024

Introduction: Potential ergonomic hazards at work can lead to complaints of musculoskeletal disorders (MSDs). The Global Burden of Disease estimated that, by 2019, there were about 1.71 billion people in the world living with musculoskeletal problems. One of the jobs that has this risk is librarians because their jobs are dominated by static postures. This study aims to determine the correlation between work posture and body mass index (BMI) with MSDs complaints among librarians at Universitas Airlangga. Methods: This study is an analytical observational research with a cross-sectional design. The sample of this study consists of the total population of librarians at Universitas Airlangga that met the inclusion criteria, totaling 28 librarians. Primary data were obtained through the direct distribution of questionnaires to librarians, observations of work posture and musculoskeletal complaints in librarians. The data in this study were analyzed using the Spearman rank correlation test. Results: The research results showed that the level of mild MSDs complaints was reported by 7 librarians (25.0%), moderate complaints by 13 librarians (46.4%), and severe complaints by 8 librarians (28.6%). The statistical test results indicate a strong and positive correlation between work posture and MSDs complaints (r = 0.444), while a weak and positive correlation was found between BMI)(r = 0.222) and years of service (r = 0.158) with musculoskeletal disorders complaints. Conclusion: This study concludes that librarians in high-risk work postures may experience musculoskeletal disorders complaints, especially in the neck, shoulders, and back areas.
The Important Role of Safety Culture in the Management of Major Industrial Accidents
Authors: Ismail Siti Noraishah , Ramli Azizan , Eka Prasetya Tofan Agung
Published: October 2024

Introduction: Major industrial accidents or disasters can have significant impacts on various aspects, including human health, the environment, societal well-being, and national economies. The concept of safety culture is increasingly receiving attention as a means of mitigating industrial mishaps. Nonetheless, a dearth of comprehensive systematic reviews exists that specifically examine the important role of safety culture in effectively mitigating severe industrial accidents across diverse industries on a global scale. Hence, the primary aim of this research is to examine the important role of safety culture in the effective management of industrial accidents across diverse sectors. Method: The systematic literature review (SLR) from the ScienceDirect database was established using the four basic procedures outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). A total of thirty-three scholarly publications were retrieved from the database, encompassing the years 2017 to 2021, which specifically address the important role of safety culture in the effective management of major industrial incidents. Results: The findings yielded two primary themes, namely, the significance of safety culture at both the managerial and employee levels. These topics were then categorised into ten subthemes. The findings indicate that safety culture exerts a significant influence at the managerial level in mitigating industrial accidents through the enhancement of safety training. Conclusion: In summary, a safety culture holds significant importance within the realm of management as it serves to effectively mitigate the occurrence of industrial accidents in the years to come.
Dermatitis among Workers and Its Relation with Personal Protective Equipment
Authors: Alayyannur Putri Ayuni , Malik Al Hakim Muhammad , Rejeki Eviyanti Puspita Sari Rr. Sri
Published: October 2024

Introduction: Every workplace must make an occupational health effort to avoid health problems. Many workers underestimate the risks of the job and, therefore, do not use safety equipment even when available. The most often reported case of occupational skin illnesses, contact dermatitis, accounts for more than 85% of all cases. This study was conducted to occupational dermatitis and its relationship to personal protective equipment (PPE) use. Methods: The literature search was carried out in April 2021. The research sources were taken from several databases with the keywords dermatitis, occupational health, and personal protective equipment. The Google Scholar database found 17,710 articles, ScienceDirect found 1,264 articles, ProQuest found 888 articles, and PubMed found 452 articles. Of the entire database, only 36 articles met the inclusion criteria. Results: This literature review shows that dermatitis is experienced by workers in various sectors including health workers, hairdressers, scavengers, farmers, fishermen, manufacturing industry workers, printing workers, and construction workers. The use of PPE can reduce the risk of dermatitis. However, in some conditions, the use of PPE has no effect or can even cause dermatitis due to irritation and allergies to the ingredients contained in the PPE. The limitation of this research is that the articles that are the source of this review are only from 2016–2021.Conclusion: Dermatitis still occurs in various occupational sectors. The risk of dermatitis can be decreased by using PPE; however, it can also cause the occurrence of dermatitis itself.
Enhancing wine authentication: leveraging 12,000+ international mineral wine profiles and artificial intelligence for accurate origin and variety prediction
Authors: Sarlo Leticia , Duroux Coraline , Clément Yohann , Lanteri Pierre , Rossetti Fabien , David Olivier , Tillement Augustin , Gillet Philippe , Hagège Agnès , David Laurent , Dumoulin Michel , Marchal Richard , Tillement Théodore , Lux François , Tillement Olivier
Published: October 2024

For the wine industry, ensuring quality and authenticity hinges on the precise determination of wine origin. In our study, we developed a fast semi-quantitative method to analyse 41 chemical elements in wine, employing inductively coupled plasma mass spectrometry (ICP-MS). This methodology characterises what we term the mineral wine profile (MWP). In contrast to an organic molecular profile, the mineral composition of a wine remains constant from the moment it is bottled. Mineral elements play a crucial role in the terroir of wine: they pass primarily from soil to grape and are then influenced by various vinification techniques. Indeed, it is widely recognised that the original soil characteristics are altered by a multitude of winemaking procedures, presenting a considerable challenge when endeavouring to extract origin-related information in a typical scenario. Our study demonstrates that statistical analyses and artificial intelligence (AI) could be a tool for accurately deciphering origin information within the MWP, provided sufficient mineral elements are measured and a comprehensive database of wine samples is employed to establish effective learning. In this study, a dataset comprising 12,966 MWPs was created in just over a year. The first analysis revealed correlations between the elements in wine, especially between rare earth elements, between macronutrients and between micronutrients. A machine learning method was then developed to assess wine origin and principal grape variety. Six models were tested by comparing the area under the receiver operating characteristic curve (AUC), with eXtreme Gradient Boosting as the chosen model. Mean accuracies of 92 % for country classification, 91 % for the French wine region, and 85 % for the main grape variety were obtained, and mean AUC scores of 0.964 for country classification, 0.961 for the French wine region and 0.914 for the main grape variety. This study represents the first comprehensive investigation at this scale on wine samples, and underscores the importance of using a comprehensive MWP dataset for AI applications when verifying wine origin. The authentication of a wine with over 99 % specificity could be routinely achievable through this approach.
Efficience de l’irrigation à la parcelle. Quelles marges de manœuvre pour des économies d’eau ?
Authors: WITTLING Claire
Published: October 2024

Le changement climatique entraîne une demande alimentaire croissante, une baisse de la disponibilité de l'eau et des utilisations concurrentes de l'eau. L'agriculture est responsable de 70 % des prélèvements d'eau douce au niveau mondial, principalement pour l’irrigation. Les économies d’eau en irrigation sont donc devenues un besoin urgent. Cet article propose une synthèse des différentes approches envisageables pour réduire la consommation de l’eau à l’échelle de la parcelle et met en évidence que :(1) Réaliser des économies d’eau en irrigation passe par la réduction des pertes en eau, c’est-à-dire par l’amélioration de l’efficience de l’irrigation à la parcelle.(2) Améliorer l’efficience à la parcelle se fait d’abord par les pratiques culturales, en particulier la gestion du sol, qui permet de mieux valoriser l’eau de pluie (et d’irrigation si nécessaire). Cependant, très peu de références sont encore disponibles sur les économies d’eau réalisables à travers ces pratiques.(3) Améliorer l’efficience se fait ensuite par la modernisation des systèmes d’irrigation : changement de système et pilotage de l’irrigation. De nombreux progrès technologiques ont été réalisés pour concevoir des systèmes d’application de l’eau économes ; par contre, les outils de pilotage de l’irrigation sont relativement peu utilisés et de grandes marges de progrès existent encore.
A Machine Learning Classification Model for Gastrointestinal Health in Cancer Survivors: Roles of Telomere Length and Social Determinants of Health
Authors: Han Claire J , Ning Xia , Burd Christine E , Tounkara Fode , Kalady Matthew F , Noonan Anne M , Von Ah Diane
Published: October 2024

Background. Gastrointestinal (GI) distress is prevalent and often persistent among cancer survivors, impacting their quality of life, nutrition, daily function, and mortality. GI health screening is important to prevent and manage this distress. However, accurate classification methods for GI health remain unexplored. We aimed to develop machine learning (ML) models to classify GI health status (better vs. worse) by incorporating biological aging and social determinants of health (SDOH) indicators in cancer survivors. Methods. We included 645 adult cancer survivors from the 1999-2002 NHANES survey. Using training and test datasets, we employed six ML models to classify GI health conditions (better vs. worse). These models incorporated leukocyte telomere length (TL), SDOH, and demographic/clinical data. Results. Among the ML models, the random forest (RF) performed the best, achieving a high area under the curve (AUC = 0.98) in the training dataset. The gradient boosting machine (GBM) demonstrated excellent classification performance with a high AUC (0.80) in the test dataset. TL, several socio-economic factors, cancer risk behaviors (including lifestyle choices), and inflammatory markers were associated with GI health. The most significant input features for better GI health in our ML models were longer TL and an annual household income above the poverty level, followed by routine physical activity, low white blood cell counts, and food security. Conclusions. Our findings provide valuable insights into classifying and identifying risk factors related to GI health, including biological aging and SDOH indicators. To enhance model predictability, further longitudinal studies and external clinical validations are necessary.
Gene Therapy Approach for Treatment of Obese Agouti Mice
Authors: Yunin Maxim A. , Boychenko Stanislav S. , Lebedev Petr , Deykin Alexey , Pokrovsky Mikhail , Egorov Alexander D.
Published: October 2024

Obesity is a significant metabolic disorder associated with excessive fat accumu-lation and insulin resistance. In this study, we explored a gene therapy approach to treat obesity in agouti mice using adeno-associated viruses (AAVs) carrying PRDM16, FoxP4, or Follistatin (FST) genes, which are known to promote the browning of white adipose tissue. Mice treated with AAVs encoding PRDM16, FoxP4, or FST genes showed a reduction in body weight (9-12%) within the first three weeks after admin-istration, compared to control groups. Lipidomic analysis of adipose tissue revealed a dramatic reduction in triacylglycerol (TAG) species with low carbon number (40-54 acyl carbones) in treated mice.
Quantifying the Societal Impact of Delayed Access to Innovative Medicines: A Mathematical Framework for Health Policy Decision-Making
Authors: Theiakou Foteini , Kastanioti Catherine , Zavras Dimitris , Rekkas Dimitris , Kontodimopoulos Nikolaos
Published: October 2024

This study presents a novel statistical framework for evaluating the social and economic impact of delays in the reimbursement of innovative medicines. With the growing importance of timely access to advanced therapies, particularly in managing chronic diseases, we develop a model that quantifies social loss in terms of life years, productivity, productivity cost and overall well-being. The framework integrates several key factors, including years of life lost, years of potential productive life lost, deaths, delays in reimbursement, and cost of labor productivity losses. By providing a comprehensive assessment of the societal costs associated with delayed access, the model offers valuable insights for policymakers seeking to balance healthcare innovation with sustainability. The results emphasize the need for efficient pharmaceutical policies that reduce delays in access to innovative treatments, promote equity in healthcare, and ensure long-term system viability. This approach has broad implications for improving health outcomes and economic productivity, particularly in publicly funded healthcare systems.
BioFire® Joint Infection Panel for Samples Other Than Synovial Fluid
Authors: Benvenuto Nicola , Di Bella Stefano , Principe Luigi , Luppino Diego , Conti Jacopo , Costantino Venera , Di Santolo Manuela , Busetti Marina , Luzzati Roberto , Zerbato Verena
Published: October 2024

Objectives: early identification of infection-causing microorganisms through multiplex PCR panels enables prompt and targeted antibiotic therapy. The study aimed to assess the performance of the BioFire® Joint Infection Panel (BF-JIP) in analysing non-synovial fluid samples. Methods: we conducted a retrospective cohort study at Trieste University Hospital, Italy, on hospitalised adults with non-synovial fluid samples tested by both BF-JIP and traditional culture methods (November 2022-April 2024). Results: we evaluated 48 samples from 45 patients, including 24 abscess drainage fluids and 10 biopsies. The BF-JIP showed high concordance (85.4%) and enhanced detection (4.3%) compared to culture methods. The BF-JIP excelled in CSF (100% accuracy and concordance) and in abscess drainage fluids (accuracy: 95.8%; concordance: 91.7%), and maintained high performance in patients under antibiotics. Conclusions: these findings suggest that BF-JIP is a valuable tool for accurate pathogen detection in various clinical samples, offering the additional advantage of being a rapid method.
HOM2 Deletion by CRISPR-Cas9 in Saccharomyces cerevisiae for decreasing Higher Alcohols in Whiskey
Authors: He Jiaojiao , Zhou Haoyang , Liang Jine , Tuerxun Kadireya , Ding Zhuoling , Zhou Shishui
Published: October 2024

In typical whiskey, the content of higher alcohols is about 1500-2000 mg/L, lead to high intoxicating degree (ID). To produce the low-ID whiskey, the Saccharomyces cerevisiae XF0-h, XF0-H and XF0-LH were successfully constructed by CRISPR-Cas9 gene editing technology to knock out HOM2 (encoding aspartate β-semialdehyde dehydrogenase) in the original strain XF0 and the LEU1 knockout strain XF0-L. The content of higher alcohols in whiskey fermented by the XF0-h, XF0-H, and XF0-LH were 704±8 mg/L, 685±6 mg/L, and 685±19 mg/L, respectively, showing reductions of 23.93%, 25.98%, and 15.81% compared to the XF0, XF0, and XF0-L. The fermentation conditions of the XF0-LH were optimized through single-factor experiments and Box-Behnken design. The optimal conditions were the wort concentration of 9.8 °P, the hydrolyzed broken rice syrup addition of 78 g/L, and the inoculum size of 2.7 × 106 cells/mL. The low-ID whiskey was brewed with higher alcohols content at 556 mg/L by 50L fermenter at the optimal conditions.
Associated Complementary Dual and Quantum Codes of Skew Constacyclic Codes
Authors: Yadav Shikha , Singh Ashutosh , Prakash Om , Solé Patrick
Published: October 2024

Consider the ring Be=Fq+uFq+⋯+ue−1Fq, ue=u (e≥2), where Fq denotes the finite field having q=pm elements (for m≥1 and a prime p), and q≡1(mode−1). Skew constacyclic codes over Be are studied in this paper. We present their generator polynomial and describe the criteria for their complementary duality. Moreover, we derive criteria for these codes to contain their dual and obtain quantum codes. Additionally, we establish a Gray map that preserves duality and investigate its properties. We also take into account additive skew constacyclic codes for this purpose and also derive criteria for the complementary duality of these codes. Finally, we provide several LCD and quantum codes (MDS/ near MDS). The latter are compared with the quantum codes obtained in the recent literature.
The Impact of Digital Technology Application on Agricultural Low-Carbon Transformation – A Case Study of the Pesticide Reduction Effect of Plant Protection Unmanned Aerial Vehicles (UAVs)
Authors: Deng Qian , Zhang Yuhan , Lin Zhuyu , Gao Xueping , Weng Zhenlin
Published: October 2024

The promotion of pesticide use reduction is an inevitable requirement for advancing green and low-carbon transformation of agriculture. Analyzing the impact and mechanism of agricultural digital technology applications, represented by plant protection unmanned aerial vehicles (UAVs), in reduction of pesticide application intensity by farming households is of great significance for exploring feasible pathways for low-carbon transformation in rice production. Based on the survey data of 455 sample farming households in Jiangxi Province, China, this paper employs the Ordinary Least Squares (OLS) and Propensity Score Matching (PSM) methods to examine the relationship between plant protection UAVs and the intensity of pesticide application. The research results indicate that the use of plant protection UAVs substantially reduces the intensity of pesticide application in rice by 24.9%. Heterogeneous analysis reveals that the inhibitory effect of plant protection UAVs on pesticide application intensity is more pronounced among non-aged farming households, large-scale farming households, and part-time farming households. Therefore, in order to achieve the goal of rlow-carbon transformation in rice production, it is essential to improve agricultural support policies and establish market promotion and application mechanisms to jointly promote the adoption of plant protection UAVs aerial spraying technology and other agricultural digital technologies.
Beaches Expulsion from Paradise: From a Natural to an Artificial Littoral in Tuscany (Italy)
Authors: Pranzini Enzo , Cinelli Irene , Anfuso Giorgio
Published: October 2024

This study investigates the shoreline evolution of the Tuscany coast (Italy) from 1878−83 to 2019. The 205 km sandy coastline, divided into 821 sectors each one 250 meters long, was analyzed to understand how human activities have altered this once-pristine coast. Sub-period analyses highlighted the impacts, both positive and negative, of various shore protection projects. Initially, regional beaches were undeveloped and accreting, except for some river deltas where alternating phases of erosion and accretion were observed. Coastal erosion began at these deltas due to reduced sediment input and expanded with the development of human settlements and tourism. Shore protection structures were quickly built to safeguard these areas: some succeeded but others increased erosion rates in downdrift sectors. Beach nourishment projects added about 1 million cubic meters of sediment since the 1980s, mostly from inland quarries. Currently, 57.8% of beaches are larger than in the 1880s, 9.4% remained the same, and 32.8% are narrower. Overall, the Tuscan coast gained 6.5 km² of beach surface with an average shoreline advancement of 32 m. Recent trends (2005-2019) show that 37.7% of the coast is eroding, 21.1% is stable, and 41.2% is accreting, with a total surface area increase of about 200,000 m². Although these changes may seem significant, from geomorphological and coastal management perspectives, they highlight that beach surface area is still increasing despite the existing reduced sediment input. This is due to the reduced loss of sediment due to the existence of morphological cells enclosed by headlands and the absence of submarine canyons directing sediments to the continental shelf.
Efficiency Analysis and Optimization of Two Speed Regions Operation of PMSM Taking into Account Iron Losses Based on Linear Non-Equilibrium Thermodynamics
Authors: Shchur Ihor , Biletskyi Yurii , Kopchak Bohdan
Published: October 2024

In this article, the linear non-equilibrium thermodynamic approach is used to analyze the energy regularities of the interior permanent magnet synchronous motor (IPMSM) taking into account iron losses. The IPMSM is considered a linear power converter (PC) that is multiple linearized at operating points with given angular velocity and load torque. A universal description of such a PC by a system of dimensionless parameters and characteristics made it possible to analyze the perfection of energy conversion in the object. For IPMSM, taking into account iron losses, a mathematical model of the corresponding PC has been built, and an algorithm and research program have been developed, which is valid in a wide range of machine speed regulations. This allows you to obtain the efficiency maps for IPMSM and choose the optimal points of PC operation according to the maximum efficiency criteria. The results of the studies demonstrate the effectiveness of the proposed method for determining the optimal reference of the components d and q of the armature current for both the MTPA strategy at motor speed adjusting below the nominal value and for the FW strategy at its adjusting above the nominal value.
Ferroptosis in the Progression of Steatotic Liver Disease in Obese Mice: Implications of Its Inhibition
Authors: Park Gi Cheol , Bang Soo-Young , Kim Ji Min , Shin Sung-Chan , Cheon Yong-il , Kim Kwang Min , Park Hanaro , Sung Eui-Suk , Lee Minhyung , Lee Jin-Choon , Lee Byung-Joo
Published: October 2024

Ferroptosis, a form of regulated cell death characterized by lipid peroxidation and iron accumulation, has been implicated in the progression of metabolic dysfunction-associated steatohepatitis (MASH) in obesity. This study investigated the role of ferroptosis in the development of hepatic steatosis and MASH in obese mice and assessed the therapeutic potential of ferrostatin-1, a ferroptosis inhibitor. C57BL/6J wild-type mice (n = 8) and ob/ob (n = 16) were maintained on a standard chow diet. Mice were divided into three groups that included C57BL/6 (n = 8), ob/ob (n = 8), and ob/ob + ferrostatin-1 (FER) (n = 8), with the latter group receiving an intraperitoneal injection of 5 μM/kg ferrostatin three times per week for eight weeks. Following treatment, serum and tissue samples were collected for analysis. Significant hepatic steatosis and increased lipogenesis markers were observed in ob/ob mice, and this was normalized in the ob/ob + FER group treated with ferrostatin-1. Elevated oxidative stress was indicated by increased reactive oxygen species (ROS) and Malondialdehyde (MDA) levels in the ob/ob group, while glutathione peroxidase 4 (GPX4) activity was significantly reduced. Ferrostatin-1 treatment decreases MDA levels and restores GPX4 activity. Additionally, ferrostatin mitigates iron overload and promotes macrophage polarization from M1 to M2, thereby reducing liver inflammation and fibrosis. Ferrostatin treatment reversed mitochondrial dysfunction in ob/ob mice Our findings revealed that ferroptosis plays a significant role in the progression of obesity to hepatic steatosis and MASH. Inhibiting ferroptosis using ferrostatin-1 effectively improves liver histology, reduces oxidative stress, normalizes lipogenesis, and modulates macrophage polarization. This study highlights the potential of targeting ferroptosis as a therapeutic strategy for obesity-related liver diseases, warranting further investigation in clinical settings.
Transfer Learning Approaches for Brain Metastases Screenings
Authors: Luu Minh Sao Khue , Tuchinov Bair N. , Suvorov Victor , Kenzhin Roman M. , Amelina Evgeniya V. , Letyagin Andrey Yu.
Published: October 2024

Brain metastasis is a severe and complicated cancer that requires timely screening and follow-up approaches using precise segmentation techniques for effective surgical intervention, radiation therapy, or monitoring the disease progression. In this study, we explore the efficacy of transfer learning in improving the automatic segmentation of brain metastases on Magnetic Resonance Imaging scans with the subsequent possibility of using it in clinical practice for preventive examinations and remote diagnostics. We train three deep learning models on a public dataset from the Brain Tumor Segmentation 2024 Challenge, then fine-tune these pretrained models on a small private dataset and compare them to models trained on private data from scratch. The results indicate that models utilizing transfer learning achieve superior accuracy and generalization in segmenting brain metastases. We also observed that the custom loss function significantly enhances performance compared to the default configuration. This study highlights the importance of leveraging transfer learning in medical imaging to address challenges associated with small, specialized datasets.
Prospects of Creating a Geopark in the Ulytau Region of Kazakhstan: Geoheritage and Geotourism Potential
Authors: Nigmatova Saida , Pirogova Tatyana , Madiyarova Ilnura , Bekbotayeva Alma , Seidali Arman , Kalibek Balzhan , Kozhakhmet Bakhtyar
Published: October 2024

The article is devoted to the study of geoheritage objects and scientific justification for the creation of a geopark in the Ulytau region of Central Kazakhstan. This region is the largest copper-bearing province in the world and has a unique natural and cultural heritage.
Purpose of the article: to show the scientific and tourist significance of geoheritage objects of the potential Ulytau Geopark. The geological history of this area tells about no less than 500 million years of the planet's development. Geological, historical and sacred objects make this area an extremely interesting object for the development of geotourism and the creation of geoparks as a basis for sustainable development of the area.
The research methods include a bibliographic method, which made it possible to collect information on the geoheritage of the territory; field survey techniques; and methods based on the evaluation of the criteria for eligibility for UNESCO Geoparks. The methodology includes five main blocks of assessment (geology and landscape, structure and management model, interpretation and environmental education, geotourism, sustainable development at the regional level) and represents an integrated interdisciplinary approach that allows to present regional features in the context of the geological heritage of the world.
Despite the length of time geology has been studied and resources actively used, geoheritage sites have not been previously studied and characterised. Geoparks in Kazakhstan are at an early stage of development and this article aims to show the potential for establishing geoparks in the Ulytau region.