bluuebunny/crossref_metadata_2025 huggingface dataset:
Study of the effect of gibberellic acid and zinc sulphate in some vegetative growth and nutritional status of Vicia fabaL.
Authors: Abd Noor Abood Hameeda
Published: August 2023

The study was conducted in the Faculty of Education for Girls/University of Kufa for the period from 27/10/2017 until 15/1/2017 to test the effect of different concentrations of zinc sulphate and Gibberellic acid in vegetative growth and leaf content of carbohydrates and proteins of the plant of the rest. (50,100,150) mg / L of Gibberellin and (20,40,60 ) mg/L zíncsulphate. After 10 days of the first treatment, the plants were sprayed again until full wetness. The plants were irrigated when needed. Use the Completely Randomized Design (CRD) where the least significant difference was used at 5% (Least Significant Difference) LSN % 5 to find the differences between the averages when the coefficients were only significant. The results of the study showed that there were significant differences in the measured growth indicators of plants with different concentrations compared to non-treated plants.
Evaluation of Characterized Depressive Disorder in Children and Adolescents: A Study of 79 Cases
Authors: Benhammou S. , Zarof H. , Raissouni M. , Kisra H.
Published: August 2023

Depression in children and adolescents is a major mental health concern, being the leading cause of illness and disability in children over ten years old. It increases the risk of suicide, affects education, social interactions, and contributes to obesity, tobacco, and substance use. The aim of this study was to highlight the sociodemographic and clinical profile of depression in young individuals, identify risk factors, and discuss appropriate therapeutic options. We conducted a retrospective descriptive and analytical study, using a questionnaire completed jointly by children with characterized depressive disorder and their parents. The study included 79 participants. Statistical analysis was performed using Jamovi version 2.3.21.0 and Microsoft Excel 2021. We found a predominance of females, with an average age of 13.5 years. Antecedents of self-harm and family history of psychiatric disorders were risk factors for suicidal ideation. Common symptoms included sleep disturbances (89.9%), irritability (83.5%), and mood sadness (70.9%). Depression had a significant impact, with 88.6% experiencing social withdrawal and 81% showing decreased school engagement, reflecting the multidimensional effects of depression. Pharmacotherapy was used in 82.3% of cases. However, therapeutic adherence was only good in 60.4% of cases. In summary, this study provides crucial insights into the characteristics, risk factors, and treatments of depression in young individuals within a specific hospital setting. It reinforces knowledge while emphasizing the importance of early and personalized intervention to counteract negative consequences during this critical age.
Tuberculous Lymphadenitis: Analysis of Cytomorphological Features with Utility of Genexpert MTB/RIF and Other Microbiological Test as an Adjunct to Cytology
Authors: Mayura Sruthi , Gaddam Prachi , Cherian Susan , Chaturvedi Uma , Naidu Raji
Published: August 2023

Objectives: This study was undertaken to categorize various cytomorphological patterns of tuberculous lymphadenitis and with utility of Xpert MTB/RIF as an adjunct to cytology. Materials and methods: Cases based on various cytomorphological features were categorized into 3 patterns as 1. Granulomatous lymphadenitis (GL), 2. Necrotizing granulomatous lymphadenitis (NGL) 3. Necrotizing lymphadenitis (NL). The utility of microbiological test on cytosmears and histopathological examination were assessed in these categories wherever available. Results: Overall cytology had 86% sensitivity, 94% specificity, 92% positive and negative predictive value for diagnosis of tuberculosis. All these categories were correlated with microbiological test and gene Xpert wherever available. NGL had higher positive predictive value indicating that this group when subjected to microbiological methods provide definite diagnosis of tuberculosis. GL had higher specificity; hence negative microbiological test should be subjected to histopathological examination to rule out other causes of granulomatous lymphadenitis. GeneXpert when combined with cytologically suspicious smears, has high sensitivity of 85% and the agreement with culture is moderate as indicated by the kappa value of 0.4%. Conclusion: A synchronous analysis of cytomorphological features and GeneXpert and other microbiological test increases the diagnostic yield of Tuberculosis. Excisional biopsy for diagnosis of tuberculosis should be recommended only for patients in whom Fine Needle Aspiration Cytology PCR is negative or there is discrepancy with the clinical impression.
Breast Cancer and Pregnancy about a Case and Review of the Literature, Experience of the Obstetric Gynecology Department of the Military Training Hospital Mohamed V of Rabat
Authors: Balde MA , Dembele C. , Messaoudi H. , Mangoub F. El , Bouhou A. Ait , Guelzim K. , Hassani MR , Babahabib A. , Kouach J.
Published: August 2023

The management of pregnancy-associated breast cancer is a challenge for physicians, often stemming from the mother's desire to carry the pregnancy to term despite the need for chemotherapy. 26-year-old patient, multiparous, with no particular history, followed from 20 weeks of amenorrhea (SA) for triple-negative infiltrating mammary carcinoma who underwent two courses of neo-adjuvant chemotherapy combining 5-Fluorouracil, Epirubicin and Cyclophosphamide after discussion in multidisciplinary consultation meeting (RCP) and the consent of the couple, who presented a threat of premature delivery at 34 WA, the day after their 2nd course of chemotherapy. The evolution of the pregnancy was favorable; the delivery was vaginally at 37 SA of a newborn with good neonatal adaptation. Several parameters must be considered when administering antineoplastics, hence the importance of close fetal and obstetric monitoring. A multidisciplinary approach is recommended for the therapeutic decision and follow-up.
Case of Systemic Lupus Erythematosus
Authors: Alalialjawala Shahaza , Algak Azza Abd Algader Ali , Elhamidi Muhammed , Madad Suleyman
Published: August 2023

SLE is multisystemic chronic autoimmune disease, about 20% of cases diagnosed during first 2 decades of life, it is more aggressive in children than in adult and requires aggressive treatment, Systemic lupus erythematosus (SLE) is the most common rheumatic disease associated with significant morbidity and mortality in children. In this article we study case report of 11 years female with newly diagnosed SLE with multiple systemic involvement.
Association of Serum Vitamin D and Calcium with Different Stages of Chronic Liver Diseases
Authors: Danish Mohammed Reazuddin , Sarker Shishir Sikto , Rahman Md. Ashiqur , Islam Md. Khademul , Ahmed Dewan Saifuddin , Habiba Umme , Jannat Sultana Meftahul , Islam Sumona
Published: August 2023

Introduction: Chronic liver disease (CLD) is a progressive condition characterized by liver tissue destruction, leading to complications such as cirrhosis. Vitamin D deficiency is highly prevalent in patients with CLD and is associated with skeletal and immune system impairments. This brief focuses on the impact of vitamin D deficiency in CLD and the significance of assessing vitamin D status and calcium levels for effective interventions and improved patient outcomes. Aim of the Study: The aim of this study was to investigate the association between the serum vitamin D and calcium with different stages of chronic liver diseases. Methods: This observational cross-sectional study was conducted in the Department of Gastroenterology at BSMMU in Dhaka, Bangladesh, over a period from April 2019 to March 2020. The study included 60 patients, of them 30 patients had chronic liver disease and a comparison group comprising 30 healthy attendants from the same department. Data were collected without interventions, cleaned, and analyzed using SPSS version 22.0. Ethical clearance of this study was obtained from the Institutional Review Board (IRB) of BSMMU, Dhaka, Bangladesh. Results: The study examined the association between serum vitamin D and calcium levels with different stages of chronic liver disease (CLD). Among the CLD patients, a significant proportion (63.4%) had deficient vitamin D levels compared to the healthy individuals (23.3%), and only 3.3% had sufficient levels (p = 0.007). Serum calcium levels were significantly lower in CLD patients (8.05 ± 0.76 mg/dl) compared to healthy individuals (8.81 ± 0.49 mg/dl) (p < 0.001). Furthermore, vitamin D levels were associated with the severity of liver cirrhosis, as higher Child-Turcotte-Pugh (CTP) classes had lower vitamin D levels (p = 0.009). These results indicate a potential link between vitamin D deficiency and advanced stages of chronic liver disease, emphasizing the importance of monitoring vitamin D and ......
Pattern of Lymph Node Involvement and Clinical Presentations of Tuberculous Cervical Lymphadenitis in a Single Center Tertiary Level Hospital
Authors: MJ Alam , FE Jonaed , MA Rifat , MA Liton , Nahiduzzaman Nahiduzzaman , IMHR Reza , SKAA Mamun
Published: August 2023

Introduction: Tuberculous cervical lymphadenitis, also known as scrofula, is a common manifestation of extra pulmonary tuberculosis. It primarily affects the lymph nodes in the neck region and is caused by Mycobacterium tuberculosis. TCL presents with distinct clinical features and a characteristic pattern of lymph node involvement. This short overview aims to analyze the pattern of lymph node involvement and clinical presentations of TCL to improve diagnostic accuracy and patient care. Aim of the study: The aimed to analyze the pattern of lymph node involvement and clinical presentations of TCL. Methods: This prospective observational study was conducted at the Dhaka Medical College Hospital, Dhaka, Bangladesh, over a period of four years. A total of 189 TCL patients were included in the study, with data collected on socio-demographic characteristics, clinical presentations, neck swelling-related characteristics, and various laboratory findings. Result: The majority of the participants were between the ages of 15-30 years (71.43%) and were predominantly female (68.25%). Fever was the most common clinical presentation (66.67%), followed by abscess (49.21%) and cough (30.16%). Unilateral neck swelling on the right side was the most prevalent (41.27%). Swollen nodes were frequently observed, primarily at node levels II, III, IV, V, and VI. High ESR (58.73%) and positive CGD on FNAC (100%) were common laboratory findings. Gene-Xpert testing showed positive results in 87.50% of cases. During the follow-up period, fever, neck pain, and neck swelling gradually decreased, while new abscess occurrences decreased over time. Surgery was performed on 4.23% of participants with single-level swollen nodes and 19.10% with multi-level swollen nodes after 1 year. Conclusion: In summary, this study on tuberculous lymphadenitis (TCL) identified consistent patterns in lymph node involvement and clinical presentations. Fever, abscess formation, and cough were common symptoms, .......
GM1 Gangliosidosis Revealed by Fetoplacental Hydrops Syndrome: A Case Report
Authors: Jounaid F. Z. , Saghir S. , Sellouti M. , Ayad A. , Radi A. , Agadr A. , Abilkassem R.
Published: August 2023

GM1 gangliosidos is describes a family of disorders that result from deficient activity of the lysosomal hydrolase, β-galactosidase, and which manifest varying degrees of neurodegeneration, retinal cherry-red spots, and visceromegaly. The three traditional subgroups of infantile, juvenile, and adult GM1 gangliosidosis show phenotypic overlap, although in general, the earlier the onset, the more severe the manifestations. This article gives an overview of the clinical signs in a patient with GM1 type 1 gangliosidosis revealed by fetoplacental hydrops syndrome.
Pulmonary Immune-Related Adverse Events of PD-1 Versus PD-L1 Checkpoint Inhibitors: A Retrospective Review of Pharmacovigilance
Authors: Ebinama Ugochi , Sheshadri Ajay , Anand Kartik , Swaminathan Iyer
Published: August 2023

Introduction

Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapeutics. However, immune-related adverse events (irAEs) increase morbidity and mortality and thereby limit therapeutic utility. The real-world incidence of the entire spectrum of pulmonary irAEs has not been systematically described. The objective of this study is to assess the risk of developing pulmonary irAEs (pneumonitis, pleural events [i.e., effusion and pleurisy], exacerbations of airway disease [i.e., bronchitis and bronchiectasis], and sarcoidosis) with exposure to five commonly used ICIs: nivolumab, pembrolizumab, durvalumab, avelumab, and atezolizumab.

Methods

We conducted a retrospective review of the Food and Drug Administration Adverse Events Reporting System (FAERS) pharmacovigilance database. We collected data from 2012 to 2021 to assess the risk of pulmonary irAEs and performed a disproportionality analysis using Open-Vigil, a software package used for analysis of pharmacovigilance data, to calculate reporting odds ratios (RORs). We used 95% CIs to evaluate the precision of RORs. An ROR greater than 1 and the upper limit of the 95% CI indicated statistical significance.

Results

A total of 17,273,403 events were reported in FAERS between 2012 and 2021. Of these, 88,099 (0.5%) were attributed to the PD-1 (programmed cell death protein 1) inhibitors and 21,905 (0.1%) to PD-L1 (programmed death ligand 1) inhibitors of interest. The most common indication for using the ICIs of interest was lung cancer: a total of 2832 (46.70%) for the PD-1 inhibitors and 1311 (70.9%) for the PD-L1 inhibitors. In the anti–PD-1 group, 2342 (38.6%) patients were hospitalized, and 1962 (32.4%) patients died from the lung adverse event. In the PD-L1 group, 744 (40.3%) patients were hospitalized, and 520 (28.1%) patients died from the event. Nivolumab resulted in the highest statistically significant risk (ROR, 10.5; 95% CI, 10.1–10.9) for pneumonitis. Avelumab had a lesser risk for pneumonitis (ROR, 0.2; 95% CI, 0.2–0.3). The risk for pleural events was highest with nivolumab (ROR, 3.6; 95% CI, 3.4–3.9), followed by pembrolizumab (ROR, 1.8; 95% CI; 1.6–2.0) (p < 0.001), with the lowest risks from durvalumab, atezolizumab, and avelumab. For ICI-related sarcoidosis, the risk was most significant with pembrolizumab (ROR, 3.6; 95% CI, 2.8–4.7), followed by nivolumab (ROR, 2.5; 95% CI, 1.9–3.5) (p < 0.001). The RORs for all five ICIs were less than 1 for exacerbations of airway diseases as compared with other drugs.

Conclusion

Using a pharmacovigilance database, we found an increased risk of multiple pulmonary irAEs after ICI therapy, particularly with PD-1 inhibitors. Further work is needed to investigate the incidence of pulmonary irAEs other than pneumonitis.
The effects of a Cilostazol, a selective phosphodiesterase III inhibitor, on liver ischemic-reperfusion injury and liver regeneration; In vitro experimental study
Authors: Aksoy Erkan , Ergenc Zeynep , Ergenc Hasan
Published: August 2023

Objective: Hepatectomy and transplantation cause liver damage through ischemic reperfusion and oxidative stress. There is no treatment available to improve liver regeneration and reduce ischemic-reperfusion injury. The present study aimed to investigate whether a selective phosphodiesterase III inhibitor, Cilostazol, improves ischemic reperfusion injury and liver regeneration following extended hepatectomy.
Material and Methods: Wistar albino rats (n=40) were randomized and divided into 4 equal groups. All rats underwent 60% hepatectomy, and Cilostazol (5 mg/kg per day) was administered to the experimental group. The subjects were sacrificed on the 4th and 7th days following the resection. Blood samples were taken to evaluate liver enzymes (ALT, AST) and liver tissue samples were taken to analyze morphology. Biochemical, morphological, and histopathological parameters were compared between Groups.
Results: No statistically significant differences were detected in ALT, AST values , and relative liver weights in rats treated with Cilostazol compared to the control group without Cilostazol. Although not statistically significant, a significant increase was detected in relative liver weight and a decrease in AST value in rats treated with Cilostazol. SOD activity was found to be significantly higher and GSH levels, MPO and AOPPs levels were significantly lower in Cilostazol applied Groups. It is seen in these findings that selective inhibition of PDE3 by Cilostazol improves hepatic circulation. It was also found that ischemic reperfusion injury decreased and regeneration markers such as mitosis index, even nucleus, and proliferating cell nuclear antigen ratio increased in rats treated with Cilostazol.
Conclusion: The present study found that selective PDE3 inhibitor Cilostazol positively affected the histopathological parameters following extended liver resection and significantly increased hepatocellular proliferation.
Building Trust in AI -A Simplified Guide to Ensure Software Quality
Authors: Devalla Sahithi , Yogix Manas Kumar
Published: August 2023

In recent years, Artificial Intelligence (AI) has emerged as an innovative technology in a variety of areas, including software development. The demand for high-quality software has grown in tandem with the increasing complexity of applications and user expectations.AI-driven approaches are revolutionizing traditional software development methodologies by automating and augmenting various stages of the development life cycle, leading to improved efficiency, reduced costs, and enhanced software quality. This research explores the crucial role of AI in developing high-quality software and its impact on the software development process. Firstly, it discusses how AI technologies like machine learning, natural language processing, and deep learning can facilitate requirements gathering, analysis, and validation, leading to better understanding and refinement of user needs. Next, it delves into the significance of AI in automating the coding process, such as generating code snippets, fixing bugs, and optimizing performance, thus accelerating development and reducing human errors. Moreover, the paper highlights the pivotal role of AI in software testing and quality assurance. AI-powered testing tools can execute comprehensive tests more efficiently, detect defects, and predict potential software vulnerabilities, thereby enhancing the overall reliability and robustness of the software product. Additionally, AI techniques can enable real-time monitoring and analytics, allowing developers to identify and address issues promptly during the software's operational phase. Furthermore, the paper addresses the ethical considerations and challenges associated with AI in software development, including bias in training data, interpretability of AI-driven decisions, and potential job displacement for software developers.
Anticolinérgicos e o risco de pneumonia em idosos
Authors: Pardin Edinho Pereira , Barbosa Brenda Zanatta , Dos Santos Robson Pereira , Mendonça e Silva Guilherme Sell de , Marcon Lara Thaís , Kolossovski Lucas Pilatti , Monteiro Betina Villaca , Marsura Cibele Leite , Munhoz Emanuel Racim , Retroz Fábio Felber , Queiroz Helton Freitas , Munhoz Luiza Racim , Silva Ailla Gabrielli Costa , Duarte Ana Vitória  Machado , Vieira Felipe Cardoso Rodrigues
Published: August 2023

A pneumonia é uma das doenças mais comuns e uma das principais causas de hospitalizações entre idosos. Em vista da frequente prescrição para idosos, a possibilidade do aumento do risco de pneumonia devido o uso de medicamentos anticolinérgicos constitui importante campo de estudo. Esta revisão sistemática objetiva investigar a associação entre o uso de medicamentos anticolinérgicos e o risco de pneumonia em pacientes idosos. Foi realizada busca nos bancos de dados PubMed, Web of Science, EBSCO e Google Scholar e com base na ferramenta PRISMA e na aplicação dos critérios de inclusão e exclusão foram selecionados 6 artigos para análise e discussão. Infere-se que o risco de pneumonia é aumentado em pacientes idosos que fazem uso de medicamentos anticolinérgicos, especialmente anticolinérgicos de maior potência e na fase de iniciação de tratamento. Médicos e demais profissionais da saúde devem levar em conta essas evidências na prática clínica em pacientes idosos.
Organoid bioprinting strategy and application in biomedicine: A review
Authors: He Chen , Yan Jiasheng , Fu Yusheng , Guo Jiuchuan , Shi Yuxing , Guo Jinhong
Published: August 2023

Organoids are three-dimensional cell structures cultured in vitro. They are self-organizing and can mimic real organs in structure and function. Bioprinting technology breaks through some limitations of organoid manufacturing, making it more widely used in drug screening, regenerative medicine, and other fields. In this review, we first introduce bioinks and bioprinting methods for stem cell and organoid bioprinting, then summarize several vascularization strategies for bioprinting organoids, and present applications in biomedicine. In the future, the development of microfluidic technology and four-dimensional bioprinting technology may be conducive to forming better bioprinted organoids.
Exosome-based bioinks for 3D bioprinting applications in tissue engineering and regenerative medicine
Authors: Wang Qian , Liu Yang , Zhang Shuqing , He Fan , Shi Tong , Li Jizong , Wang Zhimin , Jia Jia
Published: August 2023

Bioprinting is an emerging technology for tissue engineering and regenerative medicine. Despite its fast, accurate manufacture for tissues and organs in vitro, bioprinting has been seriously limited for biofabrication because of the restricted approaches to reproducing the extracellular matrix (ECM) with sufficient bioactivities for bioprinted cells. Exosomes are natural biological particles with proteins, lipids, or genetic materials. They have distinct properties and unique biological functions to manipulate cellular behaviors and cell fates, showing great potential to support cells for bioprinting. Here, we reviewed the recent progresses of exosome-advanced bioprinting for tissue engineering and regenerative medicine. Firstly, we offer an overview of the basics of exosomes and the current representative applications of exosomes in bone tissue engineering, immunological regulations, angiogenesis, and neural regenerations. Then, a brief introduction about the bioinks and the currently developed bioprinting methods is provided. We further give an in-depth review of the biomedical applications of bioprinting with exosomes, majorly in bone engineering, vascular engineering, therapy of neuron injury, and skin regeneration. We also conclude with an outlook on the challenges of the unmet needs of bioprinting cells with correspondent ECM environments through bioprinting with exosomes.
3D printing of PCL-ceramic composite scaffolds for bone tissue engineering applications
Authors: Kumar Parupelli Santosh , Saudi Sheikh , Bhattarai Narayan , Desai Salil
Published: August 2023

Three-dimensional (3D) printing was utilized for the fabrication of a composite scaffold of poly(ε-caprolactone) (PCL) and calcium magnesium phosphate (CMP) bioceramics for bone tissue engineering application. Four groups of scaffolds, that is, PMC-0, PMC-5, PMC-10, and PMC-15, were fabricated using a custom 3D printer. Rheology analysis, surface morphology, and wettability of the scaffolds were characterized. The PMC-0 scaffolds displayed a smoother surface texture and an increase in the ceramic content of the composite scaffolds exhibited a rougher structure. The hydrophilicity of the composite scaffold was significantly enhanced compared to the control PMC-0. The effect of ceramic content on the bioactivity of fibroblast NIH/3T3 cells in the composite scaffold was investigated. Cell viability and toxicity studies were evaluated by comparing results from lactate dehydrogenase (LDH) and Alamar Blue (AB) colorimetric assays, respectively. The live-dead cell assay illustrated the biocompatibility of the tested samples with more than 100% of live cells on day 3 compared to the control one. The LDH release indicated that the composite scaffolds improved cell attachment and proliferation. In this research, the fabrication of a customized composite 3D scaffold not only mimics the rough textured architecture, porosity, and chemical composition of natural bone tissue matrices but also serves as a source for soluble ions of calcium and magnesium that are favorable for bone cells to grow. These 3D-printed scaffolds thus provide a desirable microenvironment to facilitate biomineralization and could be a new effective approach for preparing constructs suitable for bone tissue engineering.
Development of an affordable extrusion 3D bioprinter equipped with a temperature-controlled printhead
Authors: Garciamendez-Mijares Carlos Ezio , Guerra-Alvarez Gilberto Emilio , Sánchez-Salazar1,4 Mónica Gabriela , García-Rubio Andrés , García-Martínez Germán , Mertgen Anne-Sophie , Ceballos-González Carlos Fernando , Bolivar-Monsalve Edna Johana , Shrike Zhang Yu , Santiago Grissel Trujillo-de , Alvarez Mario Moisés
Published: August 2023

Bioprinters show great promise as enablers of regenerative medicine and other biomedical engineering applications. In this work, we present a flexible and cost-effective design for a do-it-yourself bioprinter capable of printing/bioprinting gelatin methacryloyl (GelMA) and Pluronic constructs at flow rates of 0.05–0.1 mL/min and effective resolutions of 500–700 μm. The most distinctive feature of this bioprinter is its ability to control the rheology of bioinks simply by adjusting the extrusion temperature during printing. This is achieved by circulating temperature-controlled water within the printhead, which is engineered as a single 3D-printed component consisting of a water-recirculation jacket surrounding the ink/bioink cartridge. The flexibility to circulate either warm or cold water allows the system to be adapted according to the needs dictated by the bioink composition. Herein, we demonstrate the ability to control the printability of GelMA or Pluronic fibers by decreasing or increasing the temperature, respectively, thereby regulating its viscosity. In addition, any commercial needle with a Luer lock can be incorporated into the printhead, allowing the easy fabrication of fibers of different diameters with a single printhead. We showed that our bioprinter is capable of printing simple 2D constructs with high fidelity (i.e., lines of GelMA with a thickness of ~522 ± 36.83 μm can be printed at linear speeds of 100 mm min−1) and 3D constructs composed of as many as five layers of cell-laden 5% GelMA. We also demonstrated that C2C12 cells bioprinted through needle tips (300 μm in diameter) exhibit adequate post-printing viability (~90%), as well as spreading after 7 days of culture. The presentation of this bioprinter may contribute appreciably to the expansion of bioprinter use due to its low overall cost of manufacture, flexibility and open-source character, amenability to modification and adaptation for use with different 3D-printed printheads, and ability to bioprint using GelMA.
Nanoclay-reinforced alginate/salecan composite inks for 3D printing applications
Authors: Ianchis Raluca , Minodora Marin Maria , Leu Alexa Rebeca , Catalina Gifu Ioana , Alexandrescu Elvira , Pircalabioru Gratiela Gradisteanu , Mihail Vlasceanu George , Mihail Teodorescu George , Serafim Andrada , Preda Silviu , Lavinia Nistor Cristina , Petcu Cristian
Published: August 2023

The main objective of the present work was to produce three-dimensional (3D)- printable nanocomposite hydrogels based on two kinds of marine-sourced polysaccharides doped with nanoclay with potential biomedical application. First part of the research study investigated the preparation of the polysaccharide bicomponent hydrogel formulations followed by the selection of the optimal ratio of polysaccharides concentrations which ensured proper morphostructural stability of the 3D-printed constructs. Second step aimed to generate 3D scaffolds with high printing fidelity by modulating the nanoclay amount doped within the previously selected biopolymer ink. In compliance with the additive manufacturing experiments, the alginate–salecan hydrogels enriched with the highest nanofiller concentrations demonstrated the highest suitability for 3D printing process. The morphological and structural studies confirmed the ability of the nanocomposite formulations to efficiently produce porous 3D-printed constructs with improved fidelity. The morphostructural findings underlined the implication of choosing the appropriate ratio between components, as they have a considerable impact on the functionality of printing formulations and subsequent 3D-printed structures. Hence, from the obtained results, these novel hydrogel nanocomposites inks are considered valuable biomaterials with suitable features for applications in the additive manufacturing of 3D structures with precise shape for customized regenerative therapy.
 
Near-infrared controlled release of mesenchymal stem cells secretome from bioprinted graphene-based microbeads for nerve regeneration
Authors: Perini Giordano , Palmieri Valentina , D’Ascenzo Marcello , Colussi Claudia , Grassi Claudio , Friggeri Ginevra , Augello Alberto , Cui Lishan , Papi Massimiliano , De Spirito Marco
Published: August 2023

 Nerve damage is a prevalent and debilitating condition with limited treatment options. Recent years have seen an increased incidence of neural damage due to factors such as aging populations and traumatic brain injuries. Addressing the urgent need for effective therapies, this study explores the controlled delivery of mesenchymal stem cells (MSCs) secretome, a complex mixture of bioactive factors, which is currently being investigated for its potential in nerve regeneration. The secretome offers significant advantages over stem cells themselves, as it can be more easily characterized and controlled, enabling precise regulation of therapeutic interventions. However, the challenge lies in delivering the secretome specifically to the target anatomical region. To overcome this limitation, we propose a novel approach utilizing near-infrared (NIR) radiation-responsive bioprinted alginate-graphene oxide (AGO) microbeads. Graphene oxide (GO) is a highly biocompatible material with unique properties, including NIR responsiveness, enabling controlled release of therapeutic agents upon NIR exposure. We hypothesized that AGO microbeads could encapsulate MSCs secretome and release it in a controlled manner using NIR radiation. To investigate our hypothesis, controlled damage was induced to hippocampal neurons, and MSCs secretome was encapsulated within AGO microbeads. Subsequently, NIR radiation was applied to trigger the release of the secretome. We compared the efficacy of MSCs secretome with that of astrocytes, which also possess nerve growth and proliferation-promoting capabilities. Our findings demonstrated that the controlled release of MSCs secretome from AGO microbeads through non-invasive NIR radiation significantly promoted the proliferation and regeneration of neurons following nerve injury. AGO microbeads offer multiple advantages over conventional delivery methods, including precise control over the timing, location, and dosage of therapeutic agents. Furthermore, the potential for reduced immunogenicity and tumorigenicity enhances the safety profile of the therapy. Consequently, this study presents a promising avenue for the development of MSC-based therapies for nerve regeneration, with implications for the treatment of various neuropathies and injuries.
 
A Survivor’s Narrative of Institutional Harms Experienced in Manitoba Developmental Centre and Prisons in Canada
Authors:   , Held Myla D.
Published: August 2023

This thesis is a case study that looks at the life story of a Black man, Dwight, who had been institutionalized at the Manitoba Developmental Centre (MDC) at the age of eleven in 1967 for three years. Dwight alleges that he experienced physical and sexual abuse, which led him to using violence as self-defence against older patients until he was expelled from the institution. Shortly thereafter, Dwight entered the correctional institutions in Canada, being incarcerated in sixteen prisons after the MDC. This thesis applies Goffman’s (1961) theory of “total institutions” and critical disability theories. These theories are used to contextualize Dwight’s perspective of his experiences on the processes of institutionalization, roles in institutions, and the social construction of disabilities. Oral history or life story interviews were conducted with Dwight to gain insight regarding his institutional experiences. These life story interviews cover his life prior to institutionalization at the MDC, his time inside, and his life in the community. There are several research contributions and implications. This case study provides an outline of the Black experiences in institutions for persons with disabilities. Other research contributions are that misdiagnosis does occur and in this case was socially constructed based on the time period of the 1960s. This study contributes to research that shows that race may affect the experiences of labelling as current studies reveal that Black youth continue to be more likely to be assigned a disability diagnosis when compared to their white peers. Finally, the importance of oral history as a methodology provides rich detail and new knowledge from lived experiences that other methods may not provide in the fields of sociology, criminology, and history. Future research with survivors of MDC and other institutions may benefit using oral history as it is flexible and allows for participants to share as much as they wish. This method of inquiry also allows interviewees to be heard as persons with lived experiences of disabilities have experienced marginalization in the historical narrative of institutions.
Facies and Hydrocarbon Reservoir Rock Characterization of the Paleozoic Rocks of Peshawar Basin, Northwest Pakistan
Authors: Ahmad Sajjad , Raza Sohail , Suleman Khan
Published: August 2023

The present study details the facies description and hydrocarbon reservoir characterization of the Paleozoic rocks of Peshawar Basin, northwest Pakistan. The outcrop samples from the Cambrian-Devonian rocks along the famous Nowshera-Risalpur Road and Turlandi Village Section were investigated. The analysis of outcrop data revealed significant information regarding the facies and their depositional environments. Based on its detailed sedimentological data, it is believed that the Ambar Formation is deposited in shallow shelf-tidal flat settings, while the protolith of the Misri Banda Quartzite came from the wide beaches. The protolith of the Panjpir Formation was deposited in the shelf conditions, which shows an overall shallowing when moving up the section from the argillites and phyllites to crinoidal limestone. The Nowshera Formation was deposited as a reef complex on the shelf edge having reef core, reef breccia and a back-reef lagoon. The techniques of petrography, XRD and SEM were used for the bulk geochemical composition of the rocks focusing on their matrix, mineralogy, micro-porosity and pore-filling materials. The presence of micrite, goethite, kaolinite and illite as intergranular mass, dolomitization-induced porosity, twin cleavage plane and high dissolution porosity in the Ambar Formation can provide significant pore space to the reservoir fluids migration. Hematite with minor kaolinite, illite and chlorite as alteration products of unstable framework grains as intergranular mass and a deep seated burial diagenesis has minimized the reservoir potential in Misri Banda Quartzite. The coarse and fine calcite, dolomite, chlorite and kaolinite occur as pore-filling material between the framework grains while the high intensity of intragranular dissolution and micro intergranular connecting porosity in the Nowshera Formation makes it a promising reservoir.
Analisis Daya Saing Renewable Energy dan Fossil Energy (Studi pada Ekspor Batu Bara dan Biodiesel Indonesia)
Authors: Lusiyana Friska , Prasetyo Rizki Maulana
Published: August 2023

The production for renewable energy and fossil energy simultaneously has significant growth in advance. The fossil energy which includes Indonesia’s coal production legitimately has a significant effect on global energy demand. and impacts in export segmentation. Indonesia is the biggest coal exporter in the world. This condition simultaneously interprets significant effects on coal export. In order to reduce emission and supporting green economy, coal significantly impacted, Indonesia has not given significant effect on comparative advantages with RSCA methods and only indicate s positive coherency in 2007 and 2008. The policy to maintain coal production and export has significant nexus, Its impact to the coherency between demand for export and production policy has not interpreted alteration on global demand. In Biodiesel, Indonesia has a significant effect from 2012 to 2021 by measuring the RSCA. Adequately, this prominent form of renewable energy would give sustainable energy and replace the petrodiesel in the world. Indonesia has comparative advantages towards biodiesel’s biodiesel exporter country. Biodiesel would be an adequate replacement for fossil energy and renewable energy in the future for zero emission in 2045.Produksi energi terbarukan dan energi fosil secara menyeluruh memberikan hasil yang signifikan dalam pengembangannya. Energi fosil yang disubstitusikan dalam komoditas batu bara Indonesia memiliki dampak yang signifikan pada permintaan global dan memiliki dampak dengan permintaan dalam komoditas energi. Kondisi ini secara menyeluruh menginterpretasikan efek yang signifikan pada ekspor batu bara. Indonesia adalah eksportir terbesar komoditas batu bara. Implementasi pergerakan untuk mengurangi emisi global dan ekonomi hijau, komoditas batu bara berdampak secara signifikan. Indonesia tidak memiliki keunggulan komparatif dengan analisis menggunakan RSCA, Indonesia hanya memiliki keunggulan komparatif pada tahun 2007 dan 2008. Kebijakan untuk melindungi dan menjaga produksi dan ekspor batu bara memiliki korelasi yang signifikan. Hal tersebut berdampak pada koherensitas permintaan ekspor dan kebijakan untuk memproduksi batu bara yang tidak sesuai dengan permintaan pasar. Pada komoditas biodiesel, Indonesia memiliki hasil yang signifikan pada tahun 2012 sampai tahun 2021 dengan mengukur tingkat RSCA. Dalam konteks yang sama, penggunaan petrodiesel dapat tergantikan dengan biodiesel di dunia. Indonesia memiliki keunggulan komparatif pada ekspor biodiesel dibandingkan dengan negara eksportir terbesar lainnya. Biodiesel juga dapat mendukung zero emission pada tahun 2045 dan menggantikan energi fosil.
Analisis Pengaruh Sektor Industri Pangan terhadap Pertumbuhan Ekonomi di Indonesia Tahun 2001-2022
Authors: Amalia Syahidah , Hanapia Asep Yusup , Kadarisman Encang , Sukarso Aso
Published: August 2023

Economic growth is usually always used to analyze the results of economic development that has been implemented in a region or country. The food industry is a very important factor in economic growth in an area to meet the food needs of people in Indonesia. Even though the food industry in Indonesia continues to experience significant growth, there are still problems in the structure of the food industry in Indonesia. The purpose of this study is to determine the significance of the influence of independent variables in analyzing the influence of the food industry sector on economic growth in Indonesia. The data obtained were based on data from the Central Bureau of Statistics (BPS) from 2001 to 2022. The method in this study used a quantitative approach, namely by using multiple regression analysis, classical assumption tests, and hypothesis testing. The results of this study show that the food and beverage industry variable (X₁) partially has a positive and significant influence on economic growth (Y) or Ho is rejected and Ha is accepted. While the paper industry (X₂) and rubber industry (X₃) variables partially have no effect on economic growth (Y) or Ho is accepted and Ha is rejected.Pertumbuhan ekonomi biasanya selalu digunakan untuk menganalisis hasil dari pembangunan ekonomi yang telah dilaksanakan di suatu daerah atau negara. Industri pangan merupakan salah satu faktor yang sangat penting dalam pertumbuhan ekonomi di suatu daerah untuk memenuhi kebutuhan pangan masyarakat di Indonesia. Meskipun industri pangan di Indonesia terus mengalami pertumbuhan yang signifikan, namun masih terdapat permasalahan dalam struktur industri pangan di Indonesia. Tujuan dalam penelitian ini, yaitu untuk mengetahui signifikansi pengaruh variabel-variabel independen dalam menganalisis pengaruh sektor industri pangan terhadap pertumbuhan ekonomi di Indonesia. Data yang diperoleh berdasarkan data dari Badan Pusat Statistik (BPS) tahun 2001 sampai 2022. Metode dalam penelitian ini menggunakan pendekatan kuantitatif yaitu dengan menggunakan analisis regresi berganda, uji asumsi klasik, dan uji hipotesis. Hasil dari penelitian ini didapat bahwa variabel industri makanan dan minuman (X₁) secara parsial memiliki pengaruh positif dan signifikan terhadap pertumbuhan ekonomi (Y) atau Ho ditolak dan Ha diterima. Sedangkan variabel industri kertas (X₂) dan industri karet (X₃) secara parsial tidak berpengaruh terhadap pertumbuhan ekonomi (Y) atau Ho diterima dan Ha ditolak.
MODERN TECHNOLOGIES AND MECHANISMS FOR MANAGING THE DEVELOPMENT OF CREATIVE POTENTIAL OF ENTERPRISES IN COMPETITIVE CONDITIONS
Authors: KOMELINA Olha , KORSUNSKA Maryna
Published: August 2023

This article examines the issue of ensuring the competitiveness of Ukrainian enterprises in the face of increasing complexity in their internal and external operational environments, changes in the resource access, technologies, and knowledge. It argues that promoting innovative enterprise development requires a creative approach across various domains of human activity, including enterprise management. Creating of an environment for nurturing a company's creative potential and practicing creative management enables the establishment of new competitive advantages in both domestic and international markets. The distinct nature of innovation-driven enterprise development within the framework of heightened influence from global, international, national, regional, and local factors demands a corresponding response from enterprise management to facilitate necessary adaptations in the development of the creative potential. This particularly highlights tasks such as focusing on developing and implementing innovative technologies, customer orientation, employing contemporary analytical tools and big data to support managerial decisions regarding augmenting classical business models or devising alternative ones, managerial flexibility and rapid adaptation through the transition to project management methodologies, forming partnerships and facilitating collaboration with the other companies, startups, and research institutions as a mechanism for pooling necessary resources to jointly realize innovative ideas, and more. The levels of creative potential management within enterprises are characterized, including individual, group, organizational (enterprise-level), inter-organizational, regional, and national levels. It is argued that a key criterion for evaluating the effectiveness of innovative technologies for creative potential development is the knowledge creation. Applying of new concepts, mechanisms, and technologies in the management of innovation and creative potential development empowers enterprises to secure their competitiveness.
Implementation of Science Student Work Sheet Based on Multiple Intelligence Materials Temperature and Their Changes
Authors: Maria Maria , Silalahi Silalahi , Aggarwal Yashika , Galadima Usman
Published: August 2023

Purpose of the study: This study aimed to produce multiple intelligence-based science worksheets on temperature and change material, then to determine students' responses to science intelligence based on multiple intelligence.

Methodology: The research method used is the Research and Development (R&D) method and uses the Borg and Gall development model. This study's test subjects were Junior high school 1 Jambi City students. The research instrument was a validation questionnaire from the expert team and a student perception questionnaire. The specialist team's validation questionnaire data analysis technique used a qualitative description. The student questionnaire data analysis technique was used using a rating scale which was then interpreted qualitatively.

Main Findings: After validating the material once and validating the design three times, the Multiple Intelligences-based Science Worksheet is worth trying and gets an average percentage of student perceptions of 82% which states that this worksheet is in the "very good" category.

Novelty/Originality of this study: Know the implementation of science student worksheet based on multiple intelligence materials temperature and their changes. The impact of this research is as a reference for further research to carry out further research. Then this research impacts educators and teaching staff in improving and increasing student learning literacy and learning resources.
Optical Bullets and Domain Walls with Cross Spatio-Dispersion and Having Kudryashov’s form of Self-Phase Modulation
Authors: Elsherbeny Ahmed M. , Mirzazadeh Mohammad , Arnous Ahmed H. , Biswas Anjan , Yildirim Yakup , Dakova Anelia , Asiri Asim
Published: August 2023

In this paper, we investigate the retrieval of optical bullets and domain walls in a novel context, considering the interplay of cross spatio-dispersive effects and employing Kudryashov' s proposed form of self-phase modulation. The integration of these two key elements represents a significant advancement in the field of nonlinear optics, enabling the recovery of optical structures with enhanced precision and control. We propose an enhanced Kudryashov’s approach, which overcomes the limitations of conventional methods and facilitates the retrieval of optical bullets and domain walls even in the presence of cross spatio-dispersive effects. Kudryashov' s self-phase modulation mechanism has proven to be a powerful tool in controlling the nonlinear dynamics of optical systems, offering unique opportunities to manipulate light waves through phase variations induced by the medium' s response to intense optical fields. The results presented herein offer new insights into the intricate interplay between self-phase modulation and spatio-dispersive effects in nonlinear optical systems. Moreover, our findings provide a promising avenue for developing novel applications in ultrafast all-optical signal processing, such as the manipulation of light bullets for high-speed data transmission and storage. The enhanced retrieval and control of optical bullets and domain walls are expected to have a profound impact on the advancement of nonlinear optics and its practical implications.