bluuebunny/crossref_metadata_2025 huggingface dataset:
Ефект етил 2-(хіназолін-4-іл-аміно)-4,5,6,7-тетрагідробензо[b]тіофен-3карбоксилат гідрохлориду на ДНК, РНК, білки хроматину та вміст небілкових і пов’язаних з білками SH-груп у саркомі 45 і незмінених тканинах шкіри щурів
Authors: Бондаренко Л. Б. , Карацуба Т. А. , Хавич О. О. , Шаяхметова Г. М. , Шарикіна Н. І. , Коваленко В. М. , Харченко О. І. , Сергійчук Н. М. , Калачінська М. М.
Published: June 2020

Врахування індивідуальних особливостей окремих організмів дає можливість одержувати якісно кращі рівні виліковування навіть тяжких патологій. На жаль, традиційні методи хіміотерапії пухлин не дозволяли дотепер досягати хоч якоїсь специфічності цитотоксичної дії застосовуваних препаратів. У попередніх експериментах нами було проведене вивчення впливу потенційного протипухлинного препарату етил 2-(хіназолін-4-іл-аміно)-4,5,6,7-тетрагідробензо[b]тіофен-3-карбоксилат гідрохлориду (ЕХТК) на складові хроматину, процеси фрагментації ДНК, стан антиоксидантної системи в клітинах карциноми Герена та незмінених тканинах матки й виявлено специфічність його впливу на досліджувані показники. Це зумовлює актуальність подальшого з’ясування, чи є ця специфічність ЕХТК характерною лише для тканини матки, чи вона поширюється й на інші тканини організму. Мета дослідження – вивчити вплив ЕХТК на ДНК, РНК, білки хроматину, процеси фрагментації ДНК і показники стану антиоксидантної системи в клітинах саркоми 45 і незмінених тканинах шкіри щурів. Тварини були розподілені на 3 групи по 6 тварин у кожній: 1 – інтактні щури; 2 – негативний контроль (саркома 45); 3 – саркома 45 + ЕХТК (24,37 мг/кг). Вивчення впливу ЕХТК на ДНК, РНК, білки хроматину, процеси фрагментації ДНК, вміст небілкових і пов’язаних з білками SH-груп у саркомі 45 і незмінених тканинах шкіри показало, що дана сполука вірогідно змінювала більшість досліджуваних показників як порівняно з інтактними тваринами, так і з саркомою 45 без лікування. Специфічність впливу ЕХТК на клітини пухлин була найвираженішою щодо змін вмісту фрагментів ДНК, РНК, білків хроматину, а також небілкових і пов’язаних з білками SH-груп. Порівняння впливу ЕХТК на саркому 45 і карциному Герена показало, що нормалізуючий вплив даного похідного хіназоліну на всі досліджені показники був більш вираженим на моделі саркоми 45, ніж у карциномі Герена.
Вплив екстракту листя лепехи звичайної (Acorus calamus L.) на показники холестазу та жовчовидільну функцію печінки за експериментального гепатиту
Authors: Деримедвідь Л. В. , Коранг Л. А. , Калько К. О. , Вереітинова В. П.
Published: June 2020

Однією з складових уражень печінки є холестатичний синдром, який обумовлено порушенням утворення та відтоку жовчі в кишечник, накопиченням її компонентів у печінці та крові, що проявляється підвищенням активності в крові лужної фосфатази (ЛФ), γ-глутамілтранспептидази (γ-ГТТП), трансаміназ, вмісту холестерину, білірубіну, жовчних кислот тощо. Для корекції синдрому холестазу за алкогольної хвороби та інших уражень печінки часто використовують рослинні та синтетичні засоби з гепатопротекторною й жовчогінною активністю. Мета дослідження – вивчення впливу деалкоголізованого екстракту листя лепехи звичайної (Acorus calamus L.) на процеси жовчоутворення, жовчовиділення та холестазу за умов етанолтетрахлорметанового гепатиту в щурів. Встановлено, що використання деалкоголізованого екстракту листя лепехи звичайної в лікувально-профілактичному режимі за умов гепатиту в щурів, спричиненого введенням тетрахлорметану та етанолу, достовірно зменшує інтенсивність процесу холестазу, покращує жовчосектеторну та жовчоутворювальну функції печінки. Антихолестатичні властивості деалкоголізованого екстракту листя лепехи звичайної підтверджено достовірним зменшенням рівня непрямого та прямого білірубіну, зниженням активності ЛФ і γ-ГТТП. За показниками нормалізації швидкості секреції жовчі, вмісту в жовчі жовчних кислот і холестерину, зменшенням процесів холестазу деалкоголізований екстракт листя лепехи звичайної не поступався препаратам порівняння. Отримані дані свідчать про доцільність подальших поглиблених досліджень екстракту листя лепехи звичайної для створення на її основі ефективних гепатопротекторів.
Модуляція протизапальної активності Кеторолаку за умов фармакодинамічної взаємодії з Гідазепамом й Амітриптиліном і структурно-динамічні властивості мембран еритроцитів на тлі больового синдрому
Authors: Серединська Н. М. , Бухтіарова Т. А. , Бабенко Л. П. , Величко О. М.
Published: June 2020

Численні патологічні стани супроводжуються больовим синдромом, що потребує фармакологічної корекції. З метою посилення ефективності, зокрема, нестероїдних протизапальних засобів як знеболювальних і протизапальних препаратів нерідко застосовують препарати допоміжної (адʼювантної) терапії. Зважаючи на можливі психоемоційні розлади та порушення цілісності мембран, що можуть спостерігатися за больового синдрому, слід з’ясувати, чи доцільне застосування транквілізаторів та/або антидепресантів з аналгезуючими препаратами з метою зменшення проявів запалення та для покращання структурно-динамічних властивостей мембран клітин. Мета дослідження – вивчити аналгезуючу, протизапальну та мембраностабілізуючу дію денного транквілізатора Гідазепаму та класичного трициклічного антидепресанту Амітриптиліну на тлі больового синдрому за умов комбінованого застосування з ненаркотичним аналгетиком Кеторолаком. Результати проведених досліджень свідчать про наявність фармакодинамічної взаємодії між нестероїдними протизапальними препаратами та транквілізаторами й антидепресантами на тлі гострого больового синдрому. Гідазепаму та Амітриптиліну властива знеболювальна дія на тлі больового синдрому, спричиненого введенням формаліну, водночас вони не впливають на протибольову активність Кеторолаку й їхня власна аналгетична активність не змінюється за комбінованого застосування з Кеторолаком порівняно з монотерапією транквілізатором чи антидепресантом. Кеторолаку притаманна протинабрякова (протизапальна) активність за умов больового синдрому, індукованого хімічним агентом. Гідазепам сприяє зменшенню, а Амітриптилін – посиленню набряку як за самостійного, так і за комбінованого застосування з Кеторолаком. Гідазепам і Кеторолак за окремого й комбінованого застосування виявляють мембраностабілізуючі властивості, про що свідчить зниження константи зв’язування зонда АНС з мембраною еритроцитів до норми та захисна дія щодо структури глибинних гідрофобних ланок мембран еритроцитів. Амітриптиліну не притаманний позитивний вплив на структурно-динамічні характеристики мембран на даній моделі запального процесу. Отримані знання можуть бути врахованими за створення нових та оптимізації існуючих схем застосування аналгетиків та ад’ювантних лікарських засобів за больового синдрому хімічного генезу.
El Proyecto Patrimonio del Ayuntamiento de Aroche (Huelva) confirma la fórmula de la gestión local e integral
Authors: Medina Rosales Nieves
Published: June 2020

El artículo pretende mostrar cómo desde las administraciones más cercanas al patrimonio, los ayuntamientos, se pueden desarrollar proyectos de gestión integral del patrimonio, teniendo en cuenta los cuatro pilares básicos de la cadena de valor: la investigación, la protección, la conservación y la socialización del patrimonio. Estos trabajos inciden directamente en el desarrollo socioeconómico y cultural del municipio, muy imporante para zonas rurales de interior. Aroche (Huelva), con 3.109 habitantes, lleva desde 2004 desarrollando el Proyecto Municipal Patrimonio, un modelo de gestión integral que ha conseguido recuperar su patrimonio, investigarlo, consevarlo, portegerlo y entregarlo a la sociedad.
Preservar la identidad en la restauración centrará el próximo foro de vidrieras históricas
Authors: Santolaria Tura Anna
Published: June 2020

Desde 1993, el comité científico del Corpus Vitrearum organiza bianualmente foros internacionales sobre conservación de vidrieras históricas, ocasión para la reunión de un gran número de profesionales del sector. El undécimo Forum for the Conservation and Technology of Historic Stained Glass, programado para celebrarse en Barcelona el próximo mes de julio, actualmente pospuesto para el 8 al 10 de julio de 2021 por el contexto de crisis sanitaria internacional, está organizado por el Comité Catalán del Corpus Vitrearum y el Institut d'Estudis Catalans. Tiene como línea de reflexión el concepto de identidad y se centrará en las estrategias que en restauración permitan preservarla.
FONTÓN DEL JUNCO, M.; LEBRERO STALS, J.; ZOZAYA ÁLVAREZ, M. Genealogías del arte o la historia del arte como arte visual
Authors: Luque Rodrigo Laura
Published: June 2020

Reseña del libro FONTÓN DEL JUNCO, M.; LEBRERO STALS, J.; ZOZAYA ÁLVAREZ, M. Genealogías del arte o la historia del arte como arte visual. Madrid: Fundación Juan March: Editorial de Arte y Ciencia; Málaga: Museo Picasso Málaga, 2019
El Observatorio de Museos de España visibiliza su trabajo a través de la publicación de una web del proyecto
Authors: Del Pozo Sánchez Rocío
Published: June 2020

Nuestro país actualmente cuenta con cerca de 1.500 instituciones museísticas. El Ministerio de Cultura y Deporte fomenta tejer redes de profesionales en las que los museos puedan encontrarse y trabajar en base a objetivos comunes. Con esta voluntad nace en 2018 el Observatorio de Museos de España, para convertirse en foro de encuentro para comprender mejor el sector en su conjunto, y desde el que fomentar estudios y difundir información que aumente el conocimiento de estas instituciones por parte tanto de profesionales del sector como del público. A principios de 2020 se ha publicado la página web del proyecto, que da visibilidad al trabajo que lleva realizándose en conjunto con comunidades autónomas y ministerios desde su nacimiento.

A principios de 2020 se ha publicado la página web del proyecto, que da visibilidad al trabajo que lleva realizándose en conjunto con Comunidades autónomas y Ministerios desde 2018.
NUEVO ÁBALOS, J.L. De filigranología. Incunables y símbolos. Interpretación simbólica de filigranas papeleras en incunables de la Biblioteca de la Universidad de Sevilla
Authors: Romero Tallafigo Manuel
Published: June 2020

Reseña del libro NUEVO ÁBALOS, J. L. De filigranología. Incunables y símbolos. Interpretación simbólica de filigranas papeleras en incunables de la Biblioteca de la Universidad de Sevilla. Sevilla: Editorial Universidad de Sevilla, 2018
Ha-ha inspira el proyecto ganador para la puesta en valor del yacimiento arqueológico del arrabal de la Arrixaca en Murcia
Authors: Burgos Ruiz Francisco , De Andrés de Vicente Javier
Published: June 2020

Ha-Ha es el lema de la propuesta presentada por el equipo formado por los estudios madrileños Burgos & Garrido Arquitectos y Ayllón-Paradela-deAndrés ganadora del concurso de ideas, convocado por el Ministerio de Transportes, Movilidad y Agenda Urbana en 2019, para poner en valor el yacimiento arqueológico del arrabal andalusí de la Arrixaca y del jardín de San Esteban, situado en el centro de la ciudad de Murcia. En estas páginas los representantes de los dos estudios de arquitectura responsables del proyecto comparten sus fundamentos.
El Carnaval de Fuentes de Andalucía (Sevilla) estrena el programa Sintonizando Patrimonio
Authors: Mora Lázaro Elvira , Gutiérrez Rebollo Carmen
Published: June 2020

Sintonizando Patrimonio es un proyecto de valorización del patrimonio inmaterial de Andalucía impulsado por la Asociación Andaluza de Antropología (ASANA). Es una experiencia novedosa que aúna iniciación a la investigación para estudiantes y difusión para interesados en el patrimonio cultural andaluz. Los participantes en el programa tienen la posibilidad de poner en práctica las técnicas y métodos de la antropología a través de la observación y la participación en manifestaciones culturales. En marzo se hizo la primera salida con destino: el Carnaval de Fuentes de Andalucía. El resto de actividades programadas, que se extendían hasta septiembre de 2020, quedan sujetas al transcurso de la crisis del Covid-19. No obstante, esperamos que con el advenimiento de la normalidad el resto de salidas contempladas en Sintonizando Patrimonio puedan tener lugar y, con ello continuar con el proyecto.
El IAPH presenta Candela Canela, el libro de los sonidos "liberados”
Authors: Cuéllar Gordillo María
Published: June 2020

El pasado 6 de marzo de 2020 se presentó en la biblioteca del Instituto Andaluz del Patrimonio Histórico el cuento infantil titulado Candela Canela, editado en digital por la Consejería de Cultura y Patrimonio Histórico de la Junta de Andalucía. Este libro llevaba gestándose dos años, a partir de la inspiradora relatoría gráfica que la artista sevillana LaMari Muriel realizó del II seminario de patrimonio inmaterial organizado por el IAPH en 2017. Sus dibujos y las conclusiones del seminario encendieron la chispa con la que este proyecto editorial comenzó a cocinarse.
Exploring students’ view of using Google Docs in writing class
Authors: Hidayat Fahmi
Published: June 2020

The purpose of this study was to explore what do students really think about using google docs for peer feedback? the potential of Google Documents in facilitating and supporting pedagogical practices in a writing course at Higher Education level. In this qualitative case study, it was carried out among 34 students that working in pairs on article report writing over one academic semester. At the end of the semester, students were interviewed and the results were qualitatively analyzed. The findings show what do students feel that they are effectively tooled in helping them write a report. Is there a difference of opinion about Google Documents using outside of the classroom and traditional course?
Maxim’s Flouting: An Analysis of Classroom Interaction
Authors: Wahyudi Abdi , Yusuf Suhendra , Lestari Zubaedah Wiji
Published: June 2020

This study focuses on analyzing the maxim flouting between the teacher and students of XI IPS in SMA PGRI 2 Bandung during classroom interaction. The objective of this study is to find out the types of flouting maxim produced by teachers and students. Furthermore, this study also investigates the effects of maxims flouting to classroom activity. This study implements descriptive qualitative as the method of the study. There are five instruments used in this study; those are observation checklist, field note, the script of recorded video, questionnaire, and interview. The result of the study shows that there were four types of maxims flouting produced by the teacher and students during classroom interaction. Moreover, the researchers found four adverse effects of flouting maxim in classroom activity.
Do the Techniques Really Improve Students’ Mastery in Vocabulary?
Authors: Susiati Susiati , Kartikasari Nina
Published: June 2020

This study describes the techniques applied by teachers in teaching English vocabulary to the tenth grade students at Muhammadiyah Boarding School 1 Weleri. This study aims to determine and describe the techniques used by teachers on how teachers apply these techniques in teaching English vocabulary, and analyze the responses of students regarding the techniques used by teachers in vocabulary learning. The subjects of this study were two teachers and six tenth grade students at Muhammadiyah Boarding School 1 Weleri. The method used is descriptive qualitative. The research was obtained by observation, interview and documentation. The results of this study, researchers found five techniques used by both teachers in teaching English vocabulary. Teacher A techniques used are: (a) example sentences, (b) word syntaxes, (c) translating with dictionaries, (d) practice (oral drills and practice exercises), and (e) memorization. Teacher B techniques used are: (a) equality of words / opposites, (b) translating, (c) practice, and (e) memorization. Students‘ responses in general can accept the techniques used by both teachers, which can be seen from the attitudes, activeness, and enthusiasm of students when attending lessons. Students have different responses to the techniques used by teacher A and teacher B. With the techniques applied by the teacher in vocabulary learning, students‘ get improvement in learning English.
Pronunciation Recognition of –ed Ending Words by the Students of English Education Study Program of the University of Bengkulu
Authors: Giantari Khinanti , Sabarudin Syafrizal , Zahrida Zahrida
Published: June 2020

This research concerned with the English Education Study Program students’ recognition in pronouncing –ed ending words and the English Education Study Program students’ recognition of different enrollments. This research was a descriptive quantitative research. In this research, form of –ed ending pronunciation test of written sentences was used. The words used in the test items which consist of 40 questions. The data of this research was analyzed by using qualitative and quantitative method. The results of this research shows that the recognition of the English Education Study Program students in pronouncing –ed ending words was low with 46.6 of the average mean score. It confirmed the previous study on the ability in pronouncing morphophonemic or –ed ending words by Ningrum (2019) which conducted in the same place. Furthermore, comparison of the test result among three enrollments of samples shows that different mean score of first and third semester is 1.6 points. It is similar to the different mean score of the first and fifth semester students is 1.4 points. While, the different mean score of the fifth and third semester students is 3 points. It can be concluded that there are not any significant differences between them.
Pengaruh Pemberian Air Kelapa (Cocos nucifera L.) Dan Atonik Terhadap Pertumbuhan Tanaman Cabai Merah Besar (Capsicum annuum L.)
Authors: Fassya Hasti Maulidya , Handayani Tundjung Tripeni , Wahyuningsih Sri , Mahfut Mahfut
Published: June 2020

Large red chili pepper (Capsicum annuum L.) has a fairly complete nutrition and economic value. The supply of large red chili in the country is considered low compared to its demand, that’s why we need to increase its production. Increasing production can be done by fertilizing using natural fertilizers is coconut water (Cocos nucifera L.) and administration of Growth Regulatory Substances (ZPT) is atonik. The purpose of this research is to determine the effect of coconut water and atonic to the growth of large red chilli pepper sprouts determine which consentration of coconut water and atonic that has the most effective effect to the growth of large chilli pepper. This research was conducted in October - November 2019 at the Botany Laboratory, Department of Biology, Faculty of Mathematics and Science, University of Lampung. This research was carried out using a 2x3 factorial design using young coconut water (a) with 3 levels of concentration ie 0% v / v (a1), 25% v / v (a2) and 50% v / v (a3) and atonic solution ( b) with 2 concentrations, namely 0% v / v (b1) and 10% v / v (b2). Data analysis is the data homogeneous first with the Levene test at 5% significance level. Data analysis using analysis of variance (Analysis Of Variance) ɑ = 5%. If the interaction between the two factors is real, then proceed with the determination of the simple effect of coconut water at each level of atonic concentration with the F test at 5% significance level. The results of this research shows that the use of atonic and coconut water effects the growth of large red chili plants, and the most effective concentration to the growth of large red chilli pepper plants is the combination of 0% coconut water + 10% atonic.
Studi Literasi Taksonomi dan Penelusuran Spesimen Lektotipe Cengkih (Syzygium aromaticum (L.) Merr. & Perry)
Authors: Suparman Suparman , Nurhasanah Nurhasanah , Bahtiar Bahtiar , DAS Sri
Published: June 2020

Old scientific names of clove, Caryophyllus aromaticus, was published in 1753 by Carrolus Linnaeus and up to now it has many synonyms. Now, the old name is still recognized as basionim of clove. Merrill & Perry, based on the character, subsequently revised the genus of clove from the Caryophyllus to Syzygium, so the accepted scientific name is Syzygium aromaticum. The lectotype specimen was designed by McVaugh in 1989 and stored in BM from the Clifford collection.
Köppen’s climate classification projections for the Iberian Peninsula
Authors: Andrade C , Contente J
Published: June 2020

Projections of Köppen-Geiger climate classifications under future climate change for the Iberian Peninsula are investigated using a 7-ensemble mean of regional climate models obtained from EURO-CORDEX. Maps with predicted future scenarios for temperature, precipitation and Köppen-Geiger classification are analyzed for RCP4.5 and RCP8.5 in Iberia. Widespread statistically significant shifts in temperature, precipitation and climate regimes are projected in the 2041-2070 period, with greater shifts occurring under RCP8.5. An overall increase in temperature and a decrease in precipitation in the south-southeast is predicted. Of the two climate types, dry (B) and temperate (C), the dominant one was C in 86% of Iberia for 1961-1990, predicted to decrease by 8.0% by 2041-2070 under RCP4.5 (9.5% under RCP8.5). The hot-summer Mediterranean climate (CSa) will progressively replace CSb (warm-summer climate) in the northwestern half of Iberia until 2070. This shift, depicted by the SSIM index, is particularly noticeable in Portugal, with the projected establishment of the CSa climate by 2041-2070. The predicted retreat of humid subtropical (Cfa) and temperate oceanic (Cfb) areas in the northeast towards the Pyrenees region is noteworthy, as is the increase of desert (BW) and semi-desert (BS) climates (7.8 and 9%) in the southeast (between Granada and Valencia). Climate types BSh and BWh (hot semi-desert and hot desert, respectively), non-existent in the 1961-1990 period, are projected to represent 2.8% of the territory in 2041-2070 under RCP4.5 (5% under RCP8.5). The statistically significant projected changes hint at the disappearance of some vegetation species in certain regions of Iberia, with an expected increase in steppe, bush, grassland and wasteland vegetation cover, typical of dry climates in the southeast.
Evidence of post-larval growth-selective mortality in Atlantic mackerel revealed by the collection of young-of-the-year juveniles ingested by the northern gannet
Authors: Khamassi S , Coussau L , Guillemette M , Robert D
Published: June 2020

The growth-survival paradigm predicts that year-class strength is determined by growth-dependent mortality during the larval stage. In Atlantic mackerel Scomber scombrus, the possibility that strong growth-dependent mortality extends into the early juvenile stage has not previously been tested because of the difficulty in sampling young-of-the-year (YOY) juveniles. The present study determined the timing of the ‘endpoint’ during the early ontogeny, when growth-selective mortality decreases and recruitment is set. We relied on regurgitations from one of the main predators of mackerel, the northern gannet Morus bassanus, as a source of YOY juveniles. Early growth trajectories of YOY mackerel were reconstructed from the otolith microstructure and were compared to those of 1-yr-old (OYO) juveniles from the same cohort for the year classes of 2015 and 2017. In both cohorts, the early growth trajectory of OYO fish was faster than that of YOY juveniles, indicating that growth-selective mortality extended beyond the larval stage. For the 2017 cohort, the comparison of larval growth trajectories between 2-mo-old YOY, 3mo-old YOY and OYO juveniles indicated that strong selection for fast growth persisted until the pre-wintering period, but that winter mortality likely did not play an important role in shaping year-class strength. These findings suggest that in Atlantic mackerel, the endpoint when the relative strength of cohorts is fixed occurs at the age of 3 mo. These results highlight the importance of considering growth-dependent mortality processes occurring beyond the larval stage to obtain a better understanding of causes of recruitment variability.
INTEREST OF LEARNING LOCAL SCRIPT SASAMBO PGSD STUDENTS UNIVERSITY MATARAM
Authors: Widodo Arif , Indraswati Dyah , Novitasari Setiani , Nursaptini Nursaptini , Rahmatih Aisa Nikmah
Published: June 2020

Local scripts are priceless assets of the nation's cultural wealth. The existence of local characters today is increasingly eroded by the presence of Latin writing. Based on preliminary surveys of PGSD students, it can be seen that only a few students can read and write local scripts. On this basis, it is necessary to conduct research related to the interests of PGSD students in learning local scripts, especially NTB local scripts. The method used in this research is mixed. Data collection through surveys and interviews. Data analysis uses descriptive statistics. The subject of research is PGSD University of Mataram students. The results showed that PGSD students' interest in learning about local scripts was very low. Indicators that show low student interest in learning include not all students ever learning local scripts, the number of students interested in learning local scripts again is small, the number of students willing to search for literature is small, the number of students who like local scripts is small and the use of local scripts is also small. One reason for the lack of interest in learning is that local characters are difficult to learn and are no longer needed in practical life. Based on the results of the research above, various efforts need to be made to increase student interest in learning, one of them is through learning innovations to facilitate local learning and improve literacy
ANALISIS KELAYAKAN PEMEKARAN KECAMATAN TANA RIGHU KABUPATEN SUMBA BARAT PROVINSI NUSA TENGGARA TIMUR
Authors: Rohmadin Sulthon , Batubara Yusi Eva
Published: June 2020

Abstrak

Tulisan ini menjelaskan tentang kemungkinan kelayakan pemekaran Kecamatan Tana Righu Kabupaten Sumba Barat berdasarkan PP No. 19 Tahun 2008 tentang Kecamatan. Analisis kelayakan pemekaran Kecamatan Tana Righu dilakukan berdasarkan kelayakan administratif, teknis, dan fisik kewilayahan. Hasilnya, secara administratif, Kecamatan Tana Righu layak untuk dimekarkan. Secara teknis juga layak dimekarkan. Sedangkan secara fisik kewilayahan belum layak untuk dimekarkan.

Kata kunci: kelayakan, pemekaran, teknis, fisik kewilayahan, dan administratif.
PERAN CAMAT DALAM PELAKSANAAN PEMERINTAHAN UMUM BERDASARKAN UNDANG­UNDANG NOMOR 23 TAHUN 2014 (STUDI DI KECAMATAN JATINANGOR KABUPATEN SUMEDANG)
Authors: Hutagaol Yesiska Pebrina
Published: June 2020

ABSTRAK

Konsep pemerintahan umum berkembang dari masa kemasa. Sebelum Orde Baru, urusan pemerintahan umum hanya mengarahkan ke urusan pemerintahan daerah secara umum dan belum ada batasan yang jelas antara urusan pemerintah pusat dan daerah dan diserahkan kepada wakil pemerintah pusat di daerah. Orde Baru, urusan pemerintahan umum adalah seluruh urusan sisa yang menjadi kewenangan pemerintah pusat, yang pelaksanaannya di dekonsentrasikan kepada kepala wilayah (sampai pada tingkat kecamatan). Reformasi, pemberlakuan otonomi seluas-luasnya tidak memberikan batasan yang jelas tentang pelaksanaan urusan pemerintahan umum namun dalam Undang-Undang Nomor 23 Tahun 2014 nomenklatur urusan pemerintahan umum muncul kembali dalam Pasal 225 ayat (1) butir (1) yang menyatakan bahwa Camat menyeleggarakan Urusan Pemerintahan Umum yang dilimpahkan Bupati/Walikota pada tingkat Kecamatan. Penelitian ini menggunakan metode penelitian deskriptif kualitatif dengan pendekatan induktif. Teknik analisis dalam penelitian ini model Miles dan Huberman, tahapannya terdiri dari reduksi data, penyajian data dan simpulan verifikasi. Berdasarkan penelitian di lapangan, diperoleh hasil sebagai berikut: 1. Pelaksanaan urusan pemerintahan umum berasal dari kewenangan presiden yang dilimpahkan ke Bupati dan Walikota selanjutnya diteruskan kepada Camat dengan proses pembiayaan melalui APBN; 2. Forkompimca diketuai oleh camat 3. Model pelaksanaan urusan pemerintahan umum yang dijalankan camat jatinangor adalah model ketiga, yaitu urusan pemerintahan residu dalam hal ini urusan pemerintahan umum ditangani oleh masing-masing susunan pemerintahan.

Kata kunci:
The Level of Obesity and the Incidence Varicose Vein on Adult Patients in Public Health Center Mijen
Authors: Widyaningsih Tri Sakti , Prabu Yulianus , Kustriyani Menik
Published: June 2020

Background: Preliminary studies conducted by researchers on December 2015 at Public Health Center Mijen, Semarang get a yield of 7 people in the category of obesity, be found 2 people have a varicose veins in the legs and 5 other people not have varicose veins in the legs. Aim: Analyzing correlation between the level of obesity with events varicose vein on adult patients aged 26-45 years old in Public Health Center Mijen, Semarang. Methods: The research design was cross sectional. Samples were taken from adult obese patients who come to the Public Health Center Mijen Semarang as much as 42 respondents, selected by accidental sampling technique. Data were gathered using observation sheets, then analyzed using Spearman rank test. Results: The p-value of the Spearman rank test was 0.003, with the correlation coefficient of 0.443. Conclusion: There is a correlation between the level of obesity with the incidence of varicose veins on adult patients in Public Health Center Mijen Semarang. Suggestion: Recommended for respondent to control weight and attention intake foods consumed.

Keywords: Obesity; varicose vein, adult
Phytotoxic Effects of Three Natural Compounds: Pelargonic Acid, Carvacrol, and Cinnamic Aldehyde, against Problematic Weeds in Mediterranean Crops
Authors: Muñoz Marta , Torres-Pagán Natalia , Peiró Rosa , Guijarro Rubén , Sánchez-Moreiras Adela M. , Verdeguer Mercedes
Published: June 2020

Weeds and herbicides are important stress factors for crops. Weeds are responsible for great losses in crop yields, more than 50% in some crops if left uncontrolled. Herbicides have been used as the main method for weed control since their development after the Second World War. It is necessary to find alternatives to synthetic herbicides that can be incorporated in an Integrated Weed Management Program, to produce crops subjected to less stress in a more sustainable way. In this work, three natural products: pelargonic acid (PA), carvacrol (CV), and cinnamic aldehyde (CA) were evaluated, under greenhouse conditions in postemergence assays, against problematic weeds in Mediterranean crops Amaranthus retroflexus, Avena fatua, Portulaca oleracea, and Erigeron bonariensis, to determine their phytotoxic potential. The three products showed a potent herbicidal activity, reaching high efficacy (plant death) and damage level in all species, being PA the most effective at all doses applied, followed by CA and CV. These products could be good candidates for bioherbicides formulations.
Detection and Characterization of Porcine Sapelovirus in Italian Pig Farms
Authors: Chelli Eleonora , De Sabato Luca , Vaccari Gabriele , Ostanello Fabio , Di Bartolo Ilaria
Published: June 2020

Porcine sapelovirus (PSV) belongs to the genus Sapelovirus of the family Picornaviridae. PSV infects pigs asymptomatically, but it can also cause severe neurologic, enteric, and respiratory symptoms or reproductive failure. Sapelovirus infections have been reported worldwide in pigs. The objective of this study was to investigate the presence and the prevalence of PSV in Italian swine farms in animals of different ages to clarify the occurrence of the infection and the genetic characteristics of circulating strains. In the present study, 92 pools of fecal samples, collected from pigs across three farms, were analyzed by Reverse Transcriptase-polymerase Chain Reaction-PCR (RT-PCR). Fecal pools from young growers (63/64) were found positive for Sapelovirus in all farms while detection in sows (4/28) was observed in only one farm. Phylogenetic analyses of the 19 partial capsid protein nucleotide sequences (VP1) (6–7 each farm) enable the classification of the virus sequences into three distinct clades and highlighted the high heterogeneity within one farm. The whole genome sequence obtained from one strain showed the highest correlation with the Italian strain detected in 2015. The study adds novel information about the circulation and heterogeneity of PSV strains in Italy and considering the movement of pigs across Europe would also be informative for other countries.
No Prescription, No Problem! A Mixed-Methods Study of Antimicrobial Stewardship Relating to Working Equines in Drug Retail Outlets of Northern India
Authors: Nye Caroline , Watson Tamlin , Kubasiewicz Laura , Raw Zoe , Burden Faith
Published: June 2020

Multidrug resistance (MDR) is already occurring among some equids in India. Donkeys and mules are a mobile species moving between regions and international borders, often populating areas of India where private community pharmacies, or medical stores, are the primary healthcare provider for both humans and animals. This article highlights how the capacities of drug retail outlet workers might affect their antibiotic dispensing practices, particularly in relation to donkeys and mules, in order to consider how this might impact the development of antimicrobial resistance (AMR) on a wider scale. A mixed-methods approach was implemented using patient simulation method (n = 28), semi-structured interviews (SSIs) (n = 23), focus group discussions (FGDs) with veterinary practitioners and non-governmental organisation animal health workers (n = 2 FGDs), and participant observation. Fewer than 48 per cent of drug retail outlet workers admitted to having had any formal training in pharmaceuticals at all, while 78 per cent reported having no formal training in animal-related pharmaceuticals. Moreover, 35 per cent of all participants sold antibiotics without a prescription, unprompted and without specifically being asked for antibiotics. Of the antibiotics dispensed, only 21 per cent were correctly dispensed for the symptoms presented, and all dosages dispensed were incorrect (underdosed). Furthermore, 43 per cent of drug retail outlet workers interviewed believe that some antibiotics can be legally dispensed without a prescription. Equine owners in northern India are frequently being sold antibiotics without a prescription and, in most cases, with incorrect diagnoses, treatment choice, and dosage. A substantial gap in capacities exists amongst Drug Retail Outlet (DRO) workers, with few being sufficiently qualified or trained to dispense antibiotics to animal owners. The study highlights the need for further training of private DRO workers as well as knowledge extension and awareness training for both DRO workers and animal owners regarding antimicrobial resistance and its potential impact upon livelihoods. It also illustrates the need to identify a balance whereby greater enforcement of regulation at all levels is implemented, while at the same time maintaining sufficient access to medicine for rural populations.
Anti-Infectious Plants of the Thai Karen: A Meta-Analysis
Authors: Phumthum Methee , Balslev Henrik
Published: June 2020

Pharmacology has developed many drugs to treat infections, but many people, especially in developing countries, cannot afford to purchase them, and still depend on traditional knowledge and local medicinal plants to fight off infections. In addition, numerous microbes have developed resistance to the pharmaceutical drugs developed to fight them, and for many, such as Covid-19, effective drugs remain to be found. Ethnomedicinal knowledge is useful, not only for local people as a source of medicine for primary health care, but also for new pharmacological discoveries. This study aimed to identify the plants that the Karen, the largest hill-tribe ethnic minority in northern and western Thailand, use for treatments of infectious diseases. We present a meta-analysis of data from 16 ethnobotanical studies of 25 Karen villages with the aim of understanding traditional knowledge and treatments and point to potential plants for further pharmacological development. The Karen used 127 plant species from 59 plant families to treat infections and infectious diseases. The Cultural Important Index (CI) showed that the Leguminosae, Euphorbiaceae, Asteraceae, Lauraceae, Apocynaceae, Menispermaceae, and Lamiaceae were the most commonly used families. As for species, Cleidion javanicum, Tinospora crispa, Litsea cubeba, Aesculus assamica, Tadehagi triquetrum, Senna alata, Tithonia diversifolia, Embelia sessiliflora, and Combretum indicum were the most commonly used in treatments of infectious diseases. We suggest that these plant species should be the first to be pharmacologically tested for possible development of medicines, and the remaining species registered should subsequently undergo testing.
Obstructive Sleep Apnea and Circulating Biomarkers of Oxidative Stress: A Cross-Sectional Study
Authors: Peres Bernardo U. , Allen AJ Hirsch , Shah Aditi , Fox Nurit , Laher Ismail , Almeida Fernanda , Jen Rachel , Ayas Najib
Published: June 2020

Oxidative stress (OS) drives cardiometabolic diseases. Intermittent hypoxia consistently increases oxidative stress markers. Obstructive sleep apnea (OSA) patients experience intermittent hypoxia and an increased rate of cardiovascular disease, however, the impact of OSA on OS markers is not clear. The objective was to assess relationships between OSA severity and biomarker levels. Patients with suspected OSA referred for a polysomnogram (PSG) provided fasting blood sample. Plasma levels of 8-isoprostane, 8-hydroxydeoxyguanosine (8-OHdG), and superoxide dismutase (SOD) were measured. The relationship between OSA and OS was assessed both before and after controlling for confounders (age, sex, smoking history, history of cardiovascular disease, ethnicity, diabetes, statin usage, body mass index (BMI)). 402 patients were studied (68% male, mean age ± SD = 50.8 ± 11.8 years, apnea-hypopnea index (AHI) = 22.2 ± 21.6 events/hour, BMI = 31.62 ± 6.49 kg/m2). In a multivariable regression, the AHI significantly predicted 8-isoprostane levels (p = 0.0008) together with age and statin usage; AHI was not a predictor of 8-OHdG or SOD. Female sex (p < 0.0001) and no previous history of cardiovascular disease (p = 0.002) were associated with increased antioxidant capacity. Circulating 8-isoprostane levels may be a promising biomarker of the severity of oxidative stress in OSA patients. Prospective studies are needed to determine whether this biomarker is associated with long-term cardiometabolic complications in OSA.
Determination of Polyphenols Using Liquid Chromatography–Tandem Mass Spectrometry Technique (LC–MS/MS): A Review
Authors: López-Fernández Olalla , Domínguez Rubén , Pateiro Mirian , Munekata Paulo E.S. , Rocchetti Gabriele , Lorenzo José M.
Published: June 2020

In recent years, the consumption of polyphenols has been increasing, largely due to its beneficial effects on health. They are present in a wide variety of foods, but their extraction and characterization are complicated since they are mostly in complex matrices. For this reason, the use of selective, sensitive, and versatile analytical techniques such as liquid chromatography coupled to tandem mass spectrometry (LC–MS/MS) is necessary. In this review, the most relevant studies of the last years regarding the analysis of polyphenols in different matrices by comprehensive LC–MS/MS are discussed. Relevant steps such as extraction, sample purification, and chromatographic analysis methods are emphasized. In particular, the following methodological aspects are discussed: (a) the proper selection of the extraction technique, (b) the extraction and elution solvents, (c) the purification step, (d) the selection of both stationary and mobile phases for the chromatographic separation of compounds, and (e) the different conditions for mass spectrometry. Overall, this review presents the data from the most recent studies, in a comprehensive way, thus providing and simplifying the information of the great variety of works that exist in the literature on this wide topic.
Chemical Constituents and Biologic Activities of Sage Species: A Comparison between Salvia officinalis L., S. glutinosa L. and S. transsylvanica (Schur ex Griseb. & Schenk) Schur
Authors: Mocan Andrei , Babotă Mihai , Pop Anca , Fizeșan Ionel , Diuzheva Alina , Locatelli Marcello , Carradori Simone , Campestre Cristina , Menghini Luigi , Sisea Cristian R. , Sokovic Marina , Zengin Gokhan , Păltinean Ramona , Bădărău Sabin , C. Vodnar Dan , Crișan Gianina
Published: June 2020

Even though Salvia genus is one of the most known and studied taxa of Lamiaceae family, the knowledge regarding the chemical composition and health-related benefits of some locally used Salvia species (mostly endemic) is still scarce. In this regard, the present work aims to evaluate the chemical profile and potential bioactivities of 70% (v/v) ethanolic extracts obtained from the less-studied S. transsylvanica and S. glutinosa in comparison with S. officinalis. HPLC-PDA analysis revealed the presence of rutin and catechin as the main compounds in the extracts of the three studied species (using the employed HPLC method), whereas the presence of naringenin was highlighted only in S. glutinosa extract. Chlorogenic acid, rutin and quercetin were identified and quantified for the first time in S. transsylvanica extracts. The in vitro antioxidant capacity of each extract was tested through complementary methods (phosphomolybdenum assay, DPPH, ABTS, CUPRAC and FRAP assays), and correlated with the presence of phenolics (especially flavonoids) in high amounts. The neuroprotective and antidiabetic abilities of S. officinalis (the most active as AChE, BChE and α-glucosidase inhibitor), S. glutinosa (the most active as α-amylase inhibitor) and S. transsylvanica were also studied. For each extract it was determined the antimicrobial, antifungal and cytotoxic effects using in vitro assays. The obtained results confirm the potential of S. transsylvanica and S. glutinosa as promising sources of bioactive compounds and as a starting point for further analyses.
Multi-Point Time-Synchronized Waveform Recording for the Analysis of Wide-Area Harmonic Propagation
Authors: Babaev Stanislav , Singh Ravi Shankar , Cobben Sjef , Ćuk Vladimir , Downie Allan
Published: June 2020

This paper focuses on studying the phenomenon of harmonic distortion propagation through distribution networks. This phenomenon is governed by a combination of factors involving the nature of harmonic loads and their dynamic interaction, the influence of background voltage distortion, and harmonic impedance values. The objective of the proposed research includes evaluation of the network response at different nodes to harmonic current injections via utilizing a time-synchronized distributed measurement system. The study is performed in a fully controlled and flexible test network with three medium voltage/low voltage (MV/LV) distribution substations and several managed LV harmonic sources, namely PV inverter, single-phase EV charger and emulated harmonic load with reference current injections. A selection of the results is analyzed and interpretation of the observed phenomena is given with implications that synchronized harmonic measurements can be considered as potential powerful instruments for analyzing power quality disturbances.
Survey of Smart Parking Systems
Authors: Diaz Ogás Mathias Gabriel , Fabregat Ramon , Aciar Silvana
Published: June 2020

The large number of vehicles constantly seeking access to congested areas in cities means that finding a public parking place is often difficult and causes problems for drivers and citizens alike. In this context, strategies that guide vehicles from one point to another, looking for the most optimal path, are needed. Most contributions in the literature are routing strategies that take into account different criteria to select the optimal route required to find a parking space. This paper aims to identify the types of smart parking systems (SPS) that are available today, as well as investigate the kinds of vehicle detection techniques (VDT) they have and the algorithms or other methods they employ, in order to analyze where the development of these systems is at today. To do this, a survey of 274 publications from January 2012 to December 2019 was conducted. The survey considered four principal features: SPS types reported in the literature, the kinds of VDT used in these SPS, the algorithms or methods they implement, and the stage of development at which they are. Based on a search and extraction of results methodology, this work was able to effectively obtain the current state of the research area. In addition, the exhaustive study of the studies analyzed allowed for a discussion to be established concerning the main difficulties, as well as the gaps and open problems detected for the SPS. The results shown in this study may provide a base for future research on the subject.
Carbamoyl-Phosphate Synthase 1 as a Novel Target of Phomoxanthone A, a Bioactive Fungal Metabolite
Authors: Ceccacci Sara , Deitersen Jana , Mozzicafreddo Matteo , Morretta Elva , Proksch Peter , Wesselborg Sebastian , Stork Björn , Monti Maria Chiara
Published: June 2020

Phomoxanthone A, a bioactive xanthone dimer isolated from the endophytic fungus Phomopsis sp., is a mitochondrial toxin weakening cellular respiration and electron transport chain activity by a fast breakup of the mitochondrial assembly. Here, a multi-disciplinary strategy has been developed and applied for identifying phomoxanthone A target(s) to fully address its mechanism of action, based on drug affinity response target stability and targeted limited proteolysis. Both approaches point to the identification of carbamoyl-phosphate synthase 1 as a major phomoxanthone A target in mitochondria cell lysates, giving also detailed insights into the ligand/target interaction sites by molecular docking and assessing an interesting phomoxanthone A stimulating activity on carbamoyl-phosphate synthase 1. Thus, phomoxanthone A can be regarded as an inspiring molecule for the development of new leads in counteracting hyperammonemia states.
Biomarkers for Liquid Biopsies of Pituitary Neuroendocrine Tumors
Authors: Gossing Wilhelm , Frohme Marcus , Radke Lars
Published: June 2020

Pituitary neuroendocrine tumors (PitNET) do not only belong to the most common intracranial neoplasms but seem to be generally more common than has been thought. Minimally invasive liquid biopsies have the potential to improve their early screening efficiency as well as monitor prognosis by facilitating the diagnostic procedures. This review aims to assess the potential of using liquid biopsies of different kinds of biomarker species that have only been obtained from solid pituitary tissues so far. Numerous molecules have been associated with the development of a PitNET, suggesting that it often develops from the cumulative effects of many smaller genetic or epigenetic changes. These minor changes eventually pile up to switch critical molecules into tumor-promoting states, which may be the key regulatory nodes representing the most potent marker substances for a diagnostic test. Drugs targeting these nodes may be superior for the therapeutic outcome and therefore the identification of such pituitary-specific cellular key nodes will help to accelerate their application in medicine. The ongoing genetic degeneration in pituitary adenomas suggests that repeated tumor profiling via liquid biopsies will be necessary for personalized and effective treatment solutions.