bluuebunny/crossref_metadata_2025 huggingface dataset:
Regulatory Aspects, Types and Bioapplications of Metallic Nanoparticles:
A Review
Authors: Pawar Shrutee , Takke Anjali
Published: August 2022

Background:

Nanotechnology is rapidly advancing in almost every area such as the pharmaceutical industry, food industry, nano fabrics, electronics, wastewater treatment, and agriculture.

Introduction:

Metallic nanoparticles are commonly used in a variety of fields, but they are especially important in the pharmaceutical industry. Metallic nanoparticles have a size range of 10 nm to 100 nm.

Method:

Two techniques are used to synthesize metallic nanoparticles, top-down approach and the bottom - up approach. These techniques can be used to synthesise them using three different methods: physical, chemical, and biological. Chemical methods include coprecipitation method, reduction, sonochemical method, solvothermal method, and others, while physical methods include discharge method, milling, and ion implantation method. Biological methods include plants and their extracts, agricultural wastes, microorganisms, seaweeds. Scanning electron microscopy, transmission electron microscopy, dynamic light scanning, and other techniques are used to characterize them.

Result:

All metallic nanoparticles are biocompatible and have special optical, electrical, magnetic, and chemical properties. They are used in a variety of industries, including the pharmaceutical industry as an anticancer agent, antibacterial, antifungal, antioxidant, antidiabetic, biosensors. Gold, silver, iron oxide, zinc oxide, platinum, copper oxide, and palladium nanoparticles are the most common metal nanoparticles used in the pharmaceutical industry. Monometallic and multimetallic nanoparticles are broadly classified under this.

Conclusion:

This article focuses on the major metallic nanoparticle groups, including synthesis, applications, case studies, toxicity, regulatory aspects and innovative approaches of metallic nanomaterials.
Energy Crisis Links to Autophagy and Ferroptosis in Alzheimer’s Disease:
Current Evidence and Future Avenues
Authors: Fan Yong-Gang , Wang Zhan-You , He Da-Long
Published: August 2022

Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases
worldwide. The occult nature of the onset and the uncertainty of the etiology largely impede the development
of therapeutic strategies for AD. Previous studies revealed that the disorder of energy
metabolism in the brains of AD patients appears far earlier than the typical pathological features of
AD, suggesting a tight association between energy crisis and the onset of AD. Energy crisis in the
brain is known to be induced by the reductions in glucose uptake and utilization, which may be ascribed
to the diminished expressions of cerebral glucose transporters (GLUTs), insulin resistance,
mitochondrial dysfunctions, and lactate dysmetabolism. Notably, the energy sensors such as peroxisome
proliferators-activated receptor (PPAR), transcription factor EB (TFEB), and AMP-activated
protein kinase (AMPK) were shown to be the critical regulators of autophagy, which play important
roles in regulating beta-amyloid (Aβ) metabolism, tau phosphorylation, neuroinflammation, iron
dynamics, as well as ferroptosis. In this study, we summarized the current knowledge on the molecular
mechanisms involved in the energy dysmetabolism of AD and discussed the interplays existing
between energy crisis, autophagy, and ferroptosis. In addition, we highlighted the potential network
in which autophagy may serve as a bridge between energy crisis and ferroptosis in the progression
of AD. A deeper understanding of the relationship between energy dysmetabolism and AD may
provide new insight into developing strategies for treating AD; meanwhile, the energy crisis in the
progression of AD should gain more attention.
Serious Adverse Events Have Not Been Reported with Spinal Intrathecal
Injection of Mesenchymal Stem Cells: A Systematic Review
Authors: Barmada Amir , Sharan Joshua , Band Nicolas , Prodromos Chadwick
Published: August 2022

Background:

Mesenchymal stem cells (MSCs) are partially differentiated multipotent cells. They can be derived from various tissues such as umbilical cord, bone marrow, and adipose tissue. Intrathecal administration of MSCs has shown efficacy for various neurological conditions including multiple sclerosis, autism, traumatic brain injury, and many more.

Objective:

This review will seek to determine whether there are any serious adverse events associated with spinal intrathecal administration of MSCs

Methods:

PubMed was used to search the scientific literature for serious adverse events that are related to spinal intrathecal administration of MSCs. Disease specific searches were performed for neurological conditions that could benefit from intrathecal administration of MSCs. In addition, a general serious adverse events search was performed to identify any additional adverse events.

Results and Dicussion:

A total of 39 studies were included in our analysis. None of the studies reported serious adverse events related to spinal intrathecal administration of MSCs. Notably, no infections, clinical rejection, or tumors were identified.

Conclusion:

Properly performed spinal intrathecal injection of MSCs is exceedingly safe, with no serious adverse events reported based on our exhaustive literature search.
Changes in sleeping habits during the pubertal years; A descriptive study conducted in Jordan
Authors: Ali Reem Ahmad
Published: August 2022

Background:

There is limited information about changes in sleeping habits during the pubertal years of development among adolescents in Jordan.

Objective:

This study examined sleeping habits at the onset and end of puberty.

Methods:

This study utilized data from a nationwide survey in Jordan.

Participants: Sleeping habits were obtained from 3,661 adolescents aged 11(onset of puberty) and 15 years (end of puberty) and their mothers using a self-reported questionnaire. The number of hours slept and bedtimes and wake-up times on both school and non-school days were examined.

Results:

On school days, 60% of 11-year-old and 34% of 15-year-old adolescents slept between 8:00-10:00 pm. On school days, the 11-year-old adolescent group reported sleeping significantly longer than the 15-year-old adolescent group, and the proportions of adolescents who met the minimal recommended sleeping hours were 64% and 54%, respectively. Sleeping hours were long for both groups attending government schools; for the 15-year-old adolescent group, sleeping hours varied with family income and maternal education. In the case of both groups, on non-school days sleeping hours varied with gender, family income, and type of school.

Conclusion:

At the end of pubertal years, adolescent sleeping habits differ significantly from those of adolescents at the onset of puberty. On school days, insufficient sleep is much evident in the case of both 11 and 15-year-old adolescent groups, but more pronounced in the latter. Nursing initiatives to address poor sleeping habits among adolescents are warranted, given their efficacy in promoting healthy growth and development within this age group.
Experiences of an Adapted Physical Activity Intervention Program in Saudi Pre-Service Physical Education Teachers’ Self-Efficacy Towards Inclusion
Authors: Alhumaid Majed M. , Khoo Selina , Bastos Tânia
Published: August 2022

Introduction:

Adapted physical activity programs are considered to be one of the most effective and timely ways of increasing levels of self-efficacy among pre-service physical education teachers toward inclusive practices. However, the literature lacks adequate qualitative studies to measure the effectiveness of such programs. To address this paucity, the present study aims to explore pre-service physical education teachers’ experiences after completing a 6-week adapted physical activity intervention program designed to improve the inclusion of students with physical disabilities in general physical education settings.

Methods:

Six pre-service physical education teachers who completed a 6-week adapted physical activity intervention program participated in individual semi-structured interviews. Deductive and inductive techniques were used in the data analysis.

Results:

All the participants reported that the intervention program was relatively effective at enhancing their self-efficacy and preparation towards including students with physical disabilities in physical education classes.

Conclusion:

Regular exposure to practicum involving teaching students with disabilities is key to encouraging strong self-efficacy among pre-service PE teachers. Some suggestions for future intervention programs are provided.
Diagnosis of Power Transformer Winding Deformation Based on Centroid
Analysis of 3D Frequency Response Curve
Authors: Tang Xuan , Li Zhenhua
Published: August 2022

Background:

As the frequency of transformer winding faults becomes higher and higher,
the frequency response analysis used to detect the winding status has attracted more and more attention. At present, there is still a lack of reliable and intelligent technologies for detecting the state of
transformer windings in this field.

Methods:

In this paper, a transformer winding deformation diagnosis method based on centroid analysis of 3D frequency response curve is proposed. A 3D coordinate system is established with frequency, amplitude, and phase as the x, y, and z, respectively. The proposed method calculates the centroid
of each 3D frequency response curve through an algorithm, and establishes a 3D coordinate system
with the centroid of the normal winding 3D frequency response curve as the origin. The deviation distance and deviation angle between the centroid of mass of the 3D frequency response curve of the
faulty winding in different frequency bands and the centroid of the 3D frequency response curve of
the normal winding and the correlation coefficient of the traditional Frequency Response Analysis
(FRA) curve. are calculated. The deviation distance and angle of the centroid and the correlation coefficient of the calculated frequency band are input as features into the Support Vector Machine (SVM)
for intelligent diagnosis to achieve fault classification and optimizing its parameters with three optimization algorithms respectively.

Results:

The fault classification is realized by analyzing the distribution intervals of the centroids
of the 3D frequency response curves of the three simulated faults. The accuracy of fault diagnosis
using the 3D frequency response curve feature is significantly higher than the accuracy when using
the traditional FRA curve feature and it proves the effectiveness of the proposed method.

Conclusion:

The proposed model can effectively identify different fault types and the diagnostic
rate of the fault type is 100%.
Whether Early Steroid dose is Associated with Lower Mortality in
COVID-19 Critically Ill Patients-An Exploratory Chart Review
Authors: Goyal Abhishek , Joshi Ankur , Saigal Saurabh , Brahmam Dodda , Niwariya Yogesh , Khurana Alkesh , Khadanga Sagar , Mitra Arun
Published: August 2022

Introduction:

Steroids have shown its usefulness in critically ill COVID-19 patients. However, the time of starting steroid and dose tailored to severity remain a matter of inquiry due to still emerging evidences and wide-ranging concerns of benefits and harms. We did a retrospective record analysis in an apex teaching hospital ICU setting to explore optimal doses and duration of steroid therapy which can decrease mortality.

Methodology:

114 adults with COVID-19-ARDS admitted to ICU between 20thMarch-15thAugust2020 were included in chart review. We did preliminary exploratory analysis (rooted in steroid therapy matrix categorized by dose and duration) to understand the effect of several covariates on survival. This was followed by univariate and multivariate Cox proportion hazard regression analysis and model diagnostics.

Results:

Exploratory analysis and visualization indicated age, optimal steroid, severity (measured in P/F) of disease and infection status as potential covariates for survival. Univariate cox regression analysis showed significant positive association of age>60 years{2.6 (1.5-4.7)} and protective effect of optimum steroid{0.38(0.2-0.72)} on death (hazard) in critically ill patients. Multivariate cox regression analysis after adjusting effect of age showed protective
effect of optimum steroid on hazard defined as death {0.46(0.23-0.87),LR=17.04,(p=2e-04)}.The concordance was 0.70 and model diagnostics fulfilled the assumption criteria for
proportional hazard model.

Conclusion:

Optimal dose steroid as per defined ‘optimum’ (<24 hours and doses tailored to P/F at presentation) criteria can offer protective effect from mortality which persists after adjusting for age. This protective effect was not found to be negatively influenced by the risk of infection.
The Read-Aloud Method to Develop Reading Literacy at School’s Educational Park
Authors: Rahayu Endah Wredati , Mustadi Ali
Published: August 2022

This study aims to improve students' reading literacy through the Read-Aloud method. Students' reading literacy has decreased due to the implementation of Learning-From-Home activities as an effect of the Covid-19 pandemic. Learning in this study was done outdoor that concerned literacy activities in a School’s Education Park. This research used the Classroom Action Research (CAR). The subjects of this study were 18 graders of elementary school. Data were collected through observation, test questions, and documentation. The research instrument consisted of student observation sheets in reading activities, reading performance test items, and documentation guidelines. The data were analyzed following the descriptive qualitative techniques. The results indicated that the implementation of Read-Aloud activities at the Educational Park could improve students' reading literacy, particularly in the aspects of fluency and comprehension. For the reading fluency, the students were able to read fluently in a clear intonation with correct pronunciation and use punctuation marks appropriately. While for the comprehension, the students showed the ability to find the main idea, answer questions based on the reading, and conclude the reading content. The increase in the students' reading literacy was also supported by the assessment results, which climbed from the 'low' to the 'excellent' category.
The Effectiveness of Career Information Services with CEV Media on Elementary School Students
Authors: Basuki Agus , Kurniawan Ridwan
Published: August 2022

This study aims to determine the understanding of career information services with CEV (Career Education Video) in elementary school students. This research method is an experimental design with a quasi-experimental type of Nonequivalent Control Group Design. The subject of this research is class VI. The instrument used is the student career information scale. The research stages are pretest, treatment, andposttest. The experimental class gets service with CEV Media, while in the control class it is conventional/lecture. The analysis of research data with parametric statistics using the independent sample t-test. The results of the study indicate that there is a difference in the average value of career maturity in the two groups. The difference that occurs is 5.10 with details of 104.23 in the control class and 109.13 in the experimental class. The results of the hypothesis test show that the results are significant. This studyconcludes that service delivery with CEV Media is effective in providing career information for elementary school students.
The effect of interactivity and trust on donation and eWOM on Facebook and Instagram
Authors:   Department of Industrial Engineering, Faculty of Engineering, Kasetsart University, Bangkok, Thailand, et al. Utomo
Published: August 2022

Indonesia is a country that has experienced several earthquakes with adverse impacts. This incident triggered fundraising from various parties to help with the handling. The rise of social media affords the chance to facilitate these fundraising activities. The majority of existing research on donations focused on the role of social media in relation to intentions to donate and eWOM intentions lacked investigating the effect of donating intentions on intentions to eWOM and lacked comparing different social media platforms. Therefore, this study compared the effect of interactivity and trust in influencing Donation Intention and eWOM intention for Indonesian earthquake donations on Facebook and Instagram. The technique used was the Multi-Group Analysis (MGA) on PLS-SEM. This study found that for both Facebook and Instagram, trust and interactivity both influence Donation and eWOM Intention. In addition, donation intention influences eWOM intention. In terms of social media platform comparison, there is no difference between Facebook and Instagram regarding the relationships between variables (intention to donate, interactivity, and trust) in influencing eWOM intention. However, Instagram interactivity has a greater influence in influencing people's intentions to donate, while for Facebook, trust has a greater influence. This may be because the average age of Facebook users is higher than that of Instagram users; hence, Facebook users tend to deal more with trust issues while Instagram users seem to be more focused on interactivity. This research contributes to the understanding of online donations involving social media and charitable donations for earthquake relief in Indonesia.
“É Complicado, Eles São Muito Fechados”
Authors: Silva Noé Cardoso , Scaramuzza Genivaldo Frois
Published: August 2022

O presente artigo descreve as percepções de docentes a respeito da cultura indígena e seu ingresso em uma escola pública urbana amazônica com abordagem para as identidades e diferenças culturais desses povos originários. A pesquisa dialoga com autores/as do campo teórico dos Estudos Culturais e sua articulação com a educação (HALL, 1997; SKLIAR, 2003, CANDAU, 2014, 2012, FLEURI, 2003). A experiência de pesquisa se constituiu a partir do pressuposto da Bricolagem (NEIRA; LIPPI, 2012; KINCHELOE; BERRY, 2007), articulando entrevistas semiestruturadas, grupos de discussão on-line através de ferramentas digitais, além de análise documental. Após a realização das diferentes estratégias para produção de dados, evidencia-se a partir das narrativas e discursos que os/as professores/as, representam a cultura e identidade dos povos indígenas numa visão construída historicamente por meio do discurso colonial eurocêntrico que busca sua invisibilidade e/ou marginalização na sociedade.
Mitos e Educação Na Ancestralidade de TENTEHAR
Authors: De Sa Maria José Ribeiro , Almeida Maria da Conceição  de
Published: August 2022

O artigo trata de pedagogias da educação do povo Tentehar[1]. Com método etnográfico, o estudo foi desenvolvido junto aos Tentehar que vivem no território indígena Arariboia. Na articulação entre narrativas míticas e a memória biocultural dos interlocutores rememoramos princípios e valores que orientam o pensamento e a pedagogia no mundo indígena. O enredo foi produzido por homens e mulheres da aldeia Juçaral que compartilharam conosco saberes, modos de vida e problemas do seu cotidiano. Na cultura ancestral tentehar narrativas míticas alimentam o processo formativo entre esse povo, por seu intermédio são transmitidos valores que educam na sua cosmologia. A repetição oral é um dos métodos para se aprender e ensinar nessa cultura. Suas narrativas irrigam a memória individual e coletiva, alimentam uma pedagogia da resistência e os mantêm conectados com valores primordiais. Viver de forma mais equilibrada e sustentável é um dos seus valores ancestrais.
 
 
[1] O texto decorre da convivência de uma das autoras com o povo indígena tentehar (Guajajara) da aldeia Juçaral no Maranhão nos estudos sete anos, em trabalhos de extensão, pesquisa e outras partilhas. Os estudos que resultaram em uma tese foram autorizados pela comunidade e financiados pela Fundação de Amparo a Pesquisa do Maranhão (FAPEMA) e Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPQ).
Educação, Etnogênese Indígena e Interculturalidade
Authors: Martins Daniel Valério , Espina Bárrio Ángel Baldomero
Published: August 2022

O Dossiê Educação, Etnogênese Indígena e Interculturalidade visa compartilhar estudos, frutos de debates travados entre pesquisadoras(es) a fimde entender edifundir os impactos sociais voltados para o manejo da relação entre diferença e igualdade, com vistas a auxiliar na construção de um projeto intercultural crítico-inclusivo que passa pelo reconhecimento e pelo respeito étnico, cognitivo, político e sociocultural de grupos historicamente excluídos dos processos de constituição das Nações Modernas
Reflexões Sobre Os Direitos Indígenas No Brasil
Authors: LAVOR SOUSA MARIA VEIRISLENE
Published: August 2022

Este artigo tem como objetivo promover uma reflexão e discussão sobre os direitos indígenas, seu histórico, os principais marcos legais nacionais, internacionais, além de apontar as referidas instituições responsáveis no Brasil, buscando dar mais visibilidade aos debates atuais do cenário brasileiro sobre a temática e promover conhecimento coletivo.  A metodologia se constitui sobre uma pesquisa bibliográfica e documental, a partir de um recorte de tese autoral. Nos resultados deu-se destaque a discussão sobre os principais pontos da legislação vigente e demais questões ligadas ao tema proposto. As considerações revelam os grandes desafios impostos numa luta constante desses povos por seus direitos, apesar das conquistas desde a colonização, esses direitos estão constantemente sob ataque, através de vários processos de violações, pelo descumprimento da legislação vigente, em seus aspectos culturais, ambientais, territoriais, de saúde, educação, dentre outros.
O Povo Tembé Tenetehara
Authors: De Moraes Junior Henrique , Jathiati Parkatejê Kôkôixumti Tembé
Published: August 2022

A história Tembé perpassa pela colonização até o fortalecimento cultural-educacional. O artigo tem por objetivo analisar a resistência, a (re)existência, a luta e o poder na construção histórica do Povo Tembé Tenetehara na Amazônia Paraense entre os séculos XV e XXI. A construção metodológica do estudo caracteriza-se em uma pesquisa de campo com abordagem qualitativa de método analético com procedimento bibliográfico, fontes documentais, entrevista dialógica freireana e os cuidados éticos. Consiste também em um recorte de uma Dissertação de Mestrado, financiada pela Fundação Amazônia de Amparo à Estudos e Pesquisas do Estado do Pará. Infere-se, que a construção histórica do Povo Tembé de poder, de luta, de (re)existência e de resistência deu-se com o Movimento Indígena Tenetehara na (re)conquista do seu território na Amazônia Paraense
Reflexões Sobre o Português Falado por Povos Indígenas
Authors: Gorete Neto Maria
Published: August 2022

A entrada dos povos indígenas na universidade tem visibilizado suas culturas, cosmovisões, epistemologias e o uso que fazem de suas línguas, dentre elas a língua portuguesa. Os estudos sobre o português falado por povos indígenas são ainda poucos e necessitam de aprofundamento. É com o objetivo de contribuir para esta reflexão que este artigo discute algumas características do português indígena e analisa duas dissertações de mestrado escritas por indígenas, com o intuito de compreender como essa variedade aparece em textos acadêmicos. Espera-se que a discussão contribua para uma maior compreensão do significado desta língua para os povos indígenas e para a sua valorização, principalmente nas universidades.

Palavras-chave: português indígena; línguas indígenas; português acadêmico; identidades.
El Contexto Histórico-Real Del Idioma Tz’utujil Y Sus Desafíos En Santa Maria Visitación, Guatemala.
Authors: Dionisio Perez Francisco Efrain
Published: August 2022

A partir de 1580 el pueblo de Santa María Visitación inicia un nuevo proceso en todo sentido de la palabra y en lo que compete el idioma Tz’utujil.  Para este trabajo se desea ofrecer un recorrido histórico puntual por las que ha pasado hasta ahora el Tz’utujil -idioma-, en el que se detecta y se refleja los diferentes desafíos, acontecimientos y los actores que han participado en tal recorrido. Básicamente diserta sobre la realidad idiomática tomando en cuenta tópicos como la visión de los misioneros, la territorialidad en la aparición de nuevos grupos hablantes, la realidad escolar desde lo lingüístico y el cotejo de nuevos desafíos.
Uma Pedagogia Das Retomadas
Authors: Nóbrega Luciana Nogueira , Barbosa Lia Pinheiro
Published: August 2022

Os Anacé, povo indígena que ocupa tradicionalmente um território localizado a oeste da capital cearense, vem sendo, desde meados da década de 1990, impactado com as construções do Complexo Industrial e Portuário do Pecém. Em contraponto, parte dos Anacé tem realizado retomadas para recuperar parcelas do território e assim garantir seus direitos de existir. Nesse contexto, com base em pesquisa bibliográfica, documental e de campo, investigamos a possibilidade de falarmos em pedagogias das retomadas, compreendendo-as como potentes espaços de aprendizagem partilhada e de construção de pessoas Anacé, o que passa pela mediação dos encantados. Conforme observado, as retomadas possibilitam acessar conhecimentos múltiplos a partir de contextos pedagógicos de formação e de aprendizagens produzidos nas práticas políticas de reaver territórios, memórias, encantados, pelo que se conectam com saberes territorializados e da encantaria.
Educação Intercultural No Ensino De História E Cultura Indígena Em Tempos De Pandemia Da Covid-19
Authors: Aparecida de Pinho Vilma , Almeida da Silva Verusa , Rodrigues Eglen
Published: August 2022

Neste estudo, tivemos o objetivo de analisar as transformações dos sujeitos após estudar a História e Cultura dos povos indígenas na perspectiva da educação intercultural no âmbito do Ensino Remoto implementado em Altamira-PA durante a pandemia da Covid-19.  A abordagem qualitativa desta pesquisa vincula-se a teoria-prática e pensamento-ação, através do planejamento e estratégias pedagógicas que inserem conteúdos de história e cultura indígena em uma turma da Educação Básica. As análises foram realizadas sob o aporte teórico de Walsh (2009), Fleury (2003), Grando (2007), Geertz (1989) e Baniwa (2008). Apesar dos limites encontrados com a suspensão das atividades presenciais e dos desafios na utilização de ferramentas digitais, verificamos que o processo intersubjetivo da prática pedagógica intercultural provocou reflexões capazes de transpor as narrativas estereotipadas e estabelecer diálogos que favoreceram o respeito a diversidade étnico-cultural.
Literatura Indígena
Authors: Nink Ivonete
Published: August 2022

O presente artigo traz discussões acerca da escolha do livro didático no Brasil, da sua importância e interferência no contexto educacional e, propõe uma análise da obra aprovada e disponibilizada pelo Programa Nacional do Livro e Material Didático, da coleção Singular e Plural, da editora Moderna, Ensino Fundamental, anos finais, 6º ano, no quadriênio 2020-2023, e utilizada pela rede estadual de Rondônia, na qual leciono. O objetivo deste estudo é analisar o tratamento dado à literatura indígena na obra, observando os textos sugeridos para leitura, as atividades propostas aos alunos e as orientações destinadas ao professor. A partir de uma metodologia de pesquisa bibliográfica e documental ancoradas, principalmente, em Silva e Costa (2018), Bonin (2008), Oliveira (2008) e Munduruku (2016), são tecidas reflexões acerca da efetivação da Lei 11.645/08, que fala da obrigatoriedade do estudo da história e cultura indígena na educação básica, por meio do estudo da literatura indígena. Dentre as análises realizadas destaco que o livro didático contribui de certa forma para a execução da referida Lei, embora haja alguns equívocos e lacunas no tocante à questão indígena, mostrou-se expressivo para a efetivação de uma educação intercultural, expôs um espaço aberto ao diálogo, sobretudo quando utilizado de modo crítico.
Entrevista com Jacques Julles Sonneville
Authors: Costa Livia Fialho , Sonneville Jacques Julles
Published: August 2022

Entrevista   de  Jacques Julles Sonneville um dos idealizadores da Revista da FAEEBA - Educação e Contemporaneidade, concedida a professora Livia Fialho Costa, eidtora cientifica da Revista da fAEEBA.
Cervical Ganglioneuroma Presenting as a Neck Mass with Horner's Syndrome
Authors: Haught, BS Erica , Harper, BS Tyler , Phillips, MD Pamela , Shaffer, MD Marcus
Published: August 2022

Ganglioneuromas (GNs) are benign neoplasms of the autonomic nervous system. They are typically located in the retroperitoneum, posterior mediastinum, and adrenal gland. Rarely, they can arise in the cervical region and present as an enlarging neck mass. However, there have not been any reported cases, to our knowledge, of a GN presenting as Horner's syndrome. An 11-year-old female presented with a neck mass and a history of left-sided ptosis, miosis, and anhidrosis. The mass was excised, and pathology revealed a GN. In patients with a neck mass and Horner's syndrome, GNs should be considered as well as other nerve sheath tumors.
Impact of a Ryan White Clinic on Statewide New HIV Infections
Authors: Mansoor, MD Armaghan-e-Rehman , Sarwari, MD Arif
Published: August 2022

Introduction The Ryan White (RW) program is a cohort of services for underinsured, uninsured, and low-income patients with human immunodeficiency virus (HIV) infection. Although the RW program is known to enhance patient engagement and continuity of care, there are no studies that have investigated the direct impact of a RW clinic on statewide HIV transmission. Methods A retrospective review of 372 patients was undertaken at an HIV clinical site receiving RW funds in West Virginia (WV) in 2009-2019. Demographics, comorbid conditions, and details regarding disease acquisition were noted. In-state transmission was measured as the proportion of patients with newly diagnosed HIV who self-reported HIV acquisition within WV. With high rates of viral suppression and patient retention in our clinic, our hypothesis was that this proportion should decrease over time. Results Despite maintaining a greater than 90% retention of care and viral suppression rate over the study period, our data did not show a significant decline in the ratio of patients newly infected with HIV within WV over time (54.2% at the beginning of the study period vs 58.6% at the end, p-value 0.199). Conclusion Our results show that maintenance of high retention of care and viral suppression rates in one RW clinical site did not significantly reduce in-state transmission of HIV. Additional studies are needed to determine if maintaining high engagement in clinical services and sustained viral suppression across all HIV providers can reduce spread of in-state HIV infection.
Direct-to-Consumer Genetic Testing on Social Media: Topic Modeling and Sentiment Analysis of YouTube Users' Comments
Authors: Toussaint Philipp A , Renner Maximilian , Lins Sebastian , Thiebes Scott , Sunyaev Ali
Published: August 2022

Background

With direct-to-consumer (DTC) genetic testing enabling self-responsible access to novel information on ancestry, traits, or health, consumers often turn to social media for assistance and discussion. YouTube, the largest social media platform for videos, offers an abundance of DTC genetic testing–related videos. Nevertheless, user discourse in the comments sections of these videos is largely unexplored.

Objective

This study aims to address the lack of knowledge concerning user discourse in the comments sections of DTC genetic testing–related videos on YouTube by exploring topics discussed and users' attitudes toward these videos.

Methods

We employed a 3-step research approach. First, we collected metadata and comments of the 248 most viewed DTC genetic testing–related videos on YouTube. Second, we conducted topic modeling using word frequency analysis, bigram analysis, and structural topic modeling to identify topics discussed in the comments sections of those videos. Finally, we employed Bing (binary), National Research Council Canada (NRC) emotion, and 9-level sentiment analysis to identify users' attitudes toward these DTC genetic testing–related videos, as expressed in their comments.

Results

We collected 84,082 comments from the 248 most viewed DTC genetic testing–related YouTube videos. With topic modeling, we identified 6 prevailing topics on (1) general genetic testing, (2) ancestry testing, (3) relationship testing, (4) health and trait testing, (5) ethical concerns, and (6) YouTube video reaction. Further, our sentiment analysis indicates strong positive emotions (anticipation, joy, surprise, and trust) and a neutral-to-positive attitude toward DTC genetic testing–related videos.

Conclusions

With this study, we demonstrate how to identify users' attitudes on DTC genetic testing by examining topics and opinions based on YouTube video comments. Shedding light on user discourse on social media, our findings suggest that users are highly interested in DTC genetic testing and related social media content. Nonetheless, with this novel market constantly evolving, service providers, content providers, or regulatory authorities may still need to adapt their services to users' interests and desires.
Leaderships’ Role in Managing Crisis in the Lebanese Health Sector: An Assessment of Influencing Factors
Authors: Younis Joumana A. , Hejase Hussin Jose , Dalal Hala R. , Hejase Ale J. , Frimousse Soufyane
Published: August 2022

This paper aims to assess the healthcare leadership’s role in crisis management, examine, and investigate the influencing factors. A quantitative analysis approach with a positivism philosophy is adopted. Primary data are collected using a structured questionnaire distributed to a sample of hospital employees in Lebanon. Data analysis used IBM SPSS version 25; whereby descriptive statistics (i.e., frequencies, percentages, means, and standard deviations) and inferential statistics (i.e., factor analysis, multivariable linear regression) were obtained. Results revealed that leaders’ traits and skills like proactivity and communication, gender, hospital location, organization’s culture, and stakeholders’ engagement influence the effectiveness of leaders’ decision-making in a crisis management context. Also, the results confirmed the alternative hypotheses that the explanatory factors have a direct and statistically significant relationship with leaders’ decision-making effectiveness. Outcomes of this research serve as an eye opener to policymakers, health care managers, and stakeholders that a fully integrated effort is a must to mitigate serious crisis consequences.
Research on the Training System Construction of Meteorological Higher Talents for Lifelong Education
Authors: Xie Chengkun
Published: August 2022

Meteorological education and training is an important way for the growth of meteorological talents. Exploring and studying how to build a meteorological higher talent education and training system that meets the needs of lifelong education is of great significance to solve the talent guarantee for the sustainable development of meteorological undertakings and promote the construction of meteorological modernization. By analyzing the situation faced by the education of meteorological higher talents, this paper expounds the necessity and feasibility of constructing the training system of meteorological higher talents, puts forward the construction method, scientific connotation and key tasks of the training system of meteorological higher talents, and provides a scientific basis for how to construct the education and training system of meteorological higher talents and improve the core ability of meteorological education and training.
Macroglosia asociada al síndrome de Beckwith-Wiedemann. Reporte de caso clínico
Authors: Godínez Valdespino Jesús A , Nava Vera Bianca Yaneli , Joya Rodríguez Nuria Rebeca
Published: August 2022

El síndrome de Beckwith-Wiedemann (SBW) es una patología de origen genético multifactorial, referenciado desde 1963 hasta la actualidad. Entre las características principales de este síndrome se encuentran: gigantismo, onfalocele, visceromegalia, tumores viscerales, macroglosia en 90%, la cual interfiere con la ventilación y mecánica de la deglución. El diagnóstico clínico se realiza mediante la suma de criterios mayores y menores presentes en el paciente, corroborán- dose con distintas pruebas genéticas. El caso clínico que se describe es de un paciente de 14 meses de edad, portador del SBW con macroglosia verdadera, intervenido quirúrgicamente por glosectomía parcial y plastia en el Departamento de Cirugía Maxilofacial Pediátrica de la UMAE Hospital General CMN La Raza. Posterior a la cirugía se consigue reducir el volumen del cuerpo lingual en 30%, creando un impacto favorable en la relación cavidad oral-lingual, aumentando el espacio hipofaríngeo y retrolingual, disminuyendo el riesgo de hipoxia por obstrucción y la interferencia en la fase mecánica de la deglución. En cuanto al mejor momento para realizar la glosectomía de reducción, consideramos que ésta depende de las condiciones generales del paciente, y el grado de interferencia con los procesos vitales, por lo que se sugiere apegarse a lo escrito en las guías de práctica clínica y protocolos hospitalarios. El SBW es una condición rara; sin embargo, presenta afección multiorgánica. La macroglosia se observa en más de 90% del total de los casos, por lo que la glosectomía en forma de «ojo de cerradura» es el procedimiento quirúrgico de elección para reducir transversal y anteroposteriormente el cuerpo lingual, por medio del cual se consigue impactar de manera positiva en la habilitación de la vía aérea y digestiva, así como en la apariencia orofacial y en la competencia de la adquisición del lenguaje oral.
Implantes cigomáticos. Alternativa de tratamiento en maxilar atrófico. Reporte de caso clínico
Authors: Hernández Nava Dayanira Lorelay , López Noriega Juan Carlos , Rodríguez Tizcareño Mario Humberto , Kawakami Solís Enrique Kenji
Published: August 2022

Establecer un plan de tratamiento ideal en pacientes con atrofia maxilar severa se ha convertido en un verdadero reto; protesista y cirujano maxilofacial deberán trabajar en interdisciplina para poder rehabilitar al paciente de forma integral. La reabsorción alveolar anterior y la neumatización de los senos maxilares reduce la posibilidad de colocar implantes endoóseos de forma convencional. Se han ideado múltiples procedimientos quirúrgicos con el fin de aumentar el volumen del reborde residual, no obstante, la reconstrucción alveolar no logra mejorar las condiciones óseas o, simplemente, debido a la severidad de la reabsorción, se deben realizar múltiples cirugías o largos periodos de espera. Branemark en 1990, ideó una nueva alternativa para rehabilitar pacientes con atrofia maxilar severa, mediante la colocación de implantes cigomáticos para la rehabilitación total del maxilar, sin necesidad de realizar injertos previamente. Se presenta caso clínico de paciente desdentada superior e inferior, con atrofia maxilar severa, rehabilitada con cuatro implantes cigomáticos en maxilar y en mandíbula implantes convencionales (All-on-Four) en la Clínica de Implantología del Postgrado de Odontología, UNAM.
Heart Disease Prediction Based on Machine Learning
Authors: Shah Aarya , Patel Rutvik
Published: August 2022

Abstract: Now-a-days, if you know how to analyze the data and derive conclusions from it, then data becomes extremely valuable. And the main reason for that is the growing importance of using previous data to predict possible future scenarios with higher accuracy. We have used a dataset of around 70000 patients having symptoms related to heart diseases along with their daily activities and medical measurements like heart rate, cholesterol level, blood pressure and used 5 different binary prediction machine learning models for predicting the chances of a person getting heart related diseases in future based on the values entered by any person into our program. If you are a beginner in machine learning and you do not know where to begin or how to use machine learning then this paper will be extremely helpful for you to learn how machine learning works.
The power dynamics of crisis decision-making teams: A test of the threat-rigidity thesis
Authors: Xue Gang
Published: August 2022

According to the threat-rigidity thesis, a crisis leads to a constriction in control of a group, whereby the people with power dominate the decision-making process. I posed two competing hypotheses to extend this theory, one focused on a leader-centralized team power dynamic and the
other on an expertcentralized team power dynamic. Crisis decision-making teams were formed, each with three members: a leader, an expert, and a powerless team member. The results from 40 teams (120 individuals) suggest that when the expert in the team was competent, they were more likely to
be nominated as the most influential person. However, when the expert was incompetent, the leader was more likely to be nominated as the most influential person. In addition, the groups were likely to come to a correct choice in group discussion regardless of who was the most influential person.
These results challenge threat-rigidity theory by suggesting groups can function adaptively in response to crisis situations.
Colombian HIV/AIDS registry and health risk management
Authors: Castillo-Cañón Julieth C. , Trujillo-Cáceres Silvia J. , Álvarez-Moreno Carlos A. , Valbuena-García Ana M. , Luque-Núñez Ricardo , Ríos-Hincapié Cielo Y. , Acuña-Merchán Lizbeth A.
Published: August 2022

HIV/AIDS information systems are a critical tool for keeping track of the HIV pandemic in any country, leading to the AIDS elimination to 2030 and achievement of the 95-95-95 goals set by 2025. In this article, we describe the data management process of the Colombian National HIV/AIDS registry, its epidemiological results and contributions to research and health risk management. This registry is a longitudinal database. Variables and periodicity are defined by The Ministry of Health and Social Protection. Reporting is done by health insurers and their healthcare providers on annual bases. The information is uploaded through a web platform run by the High-Cost Diseases Fund, in charge of the validation, auditing process, consolidation, analysis and publication of the data. Security and confidentiality of the information is also taken care of by the High-Cost Disease Fund. Main results include epidemiological follow up of the epidemic, periodic evaluation of 25 risk management indicators, publication of research studies and the calculation of an economic incentive for insurers to improve health risk management. The registry has shown to be useful not only for the management of clinical information but also for administrative purposes.
Statistical analysis of 484 Mycobacterium tuberculosis genomes reveals an association between single nucleotide polymorphisms on ponA1 gene and LAM and Haarlem lineages
Authors: Rabanal Jhonatan , Zimic Mirko
Published: August 2022

Objectives: Evaluate the association between rifampicin resistance and the presence of at least one SNP in the rpoB and ponA1 genes and the spoligotype defined lineages. Material and Methods: This study analyzed two databases of 484 genomes of M. tuberculosis from strains isolated from patients in the cities of Lima and Callao, for which the odds ratio (OR) was calculated considering belonging to a certain spoligotype defined lineages as an exposure factor. Results: No statistically significant association (? value> 0.05) was found between the presence of at least one SNP in the rpoB gene and the lineages included in the study (LAM, Haarlem, T and Beijing). However, a statistically significant association was found between the presence of at least one SNP in the ponA1 gene and the LAM and Haarlem lineages (? value <0.05). An association was found between the P631S SNP in the ponA1 gene and the LAM and Haarlem lineages; and the A516T SNP, of this same gene, presented an association with the LAM lineage. Likewise, an association was found between rifampicin resistance and the LAM lineage. Conclusions: The presence of SNPs in the ponA1 gene is associated with the LAM and Haarlem lineages.
Infección de cavidad anoftálmica por Scedosporium sp. en paciente inmunocompetente: Reporte de caso
Authors: Martínez-Córdoba Claudia , Muñoz-Salazar Lina , Contreras-Vargas Carlos , Ruiz-Robles Luis Alberto
Published: August 2022

Scedosporium sp. es un género de hongos filamentosos que de forma infrecuente se relaciona a infecciones localizadas o diseminadas en pacientes inmunocomprometidos, o inmunocompetentes con trauma penetrante contaminado. Reportamos el caso de un paciente masculino de 31 años con antecedente de trauma penetrante por arma de fuego requiriendo enucleación de su ojo izquierdo, quien 12 años posterior al trauma inicial presenta necrosis de la cavidad anoftálmica con extrusión del implante y lisis del párpado inferior, finalmente identificando Scedosporium sp. como germen causal, y un mucocele en el seno frontal como reservorio. El paciente recibió tratamiento médico con voriconazol sistémico, desbridamiento quirúrgico amplio, y resección endoscópica del quiste de retención mucoso, con una evolución satisfactoria. Las infecciones micóticas de la cavidad anoftálmica son infrecuentes, requiriendo una alta sospecha diagnóstica y tratamiento agresivo para evitar consecuencias potencialmente devastadoras.
ANALISIS TOTAL KOLONI DAN UJI KADAR ALKOHOL PADA FERMENTASI AIR NIRA (Arenga pinnata)
Authors: Sri Rizki  , Syafrina Sari Lubis
Published: August 2022

Air nira aren mengandung glukosa, sukrosa, fuktosa, karbohidrat, dengan pH 6-7 dan berbau harum. Penelitian ini bertujuan untuk menghitung total koloni dan kadar alkohol selama proses fermentasi air nira secara spontan dengan waktu 0-72 jam. Total koloni pada air nira aren (Arenga pinnata) pada 24 jam pada pengenceran 10-1 tidak dapat dihitung karena terlalu besar, 10-2 (2,06x102 cfu/ml), 10-3 (0,167x103 cfu/ml). Total koloni pada 48 jampada pengenceran 10-1 (11,4x101 cfu/ml), 10-2 (0,87x10-2 cfu/ml) dan 10-3 (0,069x103 cfu/ml) dan 72 jam pada pengenceran 10-1(10,3x101 cfu/ml), 10-2 (0,86x102 cfu/ml) dan 10-3 (0.036x103 cfu/ml). Pengukuran kadar alkohol pada air nira dari waktu (0-72 jam) mengalami peningkatan yaitu pada 0 jam belum terbentuk alkohol sedangkan pada 24 jam kadar alkohol yang didapat 0%, 48 jam kadar alkohol yang dihasilkan 0,1% dan pada 72 jam 0,2%.
PENGARUH KOMBINASI BAP (Benzylamino purin) DAN TDZ (Thidiazuron) TERHADAP PERTUMBUHAN TANAMAN PISANG CAVENDISH (Musa acuminata cavendish) MELALUI KULTUR IN -VITRO
Authors: Nanda Raudhatul Jannah  , Muslich Hidayat  , Yunizar Hendri
Published: August 2022

Teknik kultur in-vitro adalah perbanyakan benih dengan menggunaan media buatan dalam kondisi aseptik. Salah satu jenis Tanaman pisang yang memiliki nilai komersial tinggi serta berpeluang untuk dikembangkan yakni pisang Cavendish (Musa acuminata Cavendish). Penelitian ini bertujuan untuk mendapatkan kombinasi perlakuan terbaik pada teknik kultur jaringan pisang Cavendish dengan zat pengatur tumbuh Benzylaminopurin (BAP) dan Thidiazuron (TDZ) pada media kultur in vitro. Penelitian dilaksanakan Di Laboratorium Kultur Jaringan Dinas Pertanian Dan Pangan Aceh Barat Daya, yang berlokasi di Padang Merante, Susoh, Aceh Barat Daya, dari 02 Agustus 2021 sampai dengan 14 September 2021. Hasil penelitian menunjukkan bahwa kombinasi BAP dengan TDZ berpengaruh nyata terhadap jumlah muncul tunas dibandingkan pemberian BAP tanpa kombinasi dan mampu memacu lebih cepat menginduksi pembentukan tunas dan perbanyakan dari eksplan pisang Cavendish.