bluuebunny/crossref_metadata_2025 huggingface dataset:
To Analyze the Mechanism of Glycyrrhiza uralensis (Licorice) in the Treatment of COVID-19 Based on Network Pharmacology and Molecular Docking Technology
Authors:   Shihezi University, China, Zhang Junyi , Yang Xuhai ,   Shihezi University, China, Zhu Lichun ,   Shihezi University, China, He Ruiying ,   Shihezi University, China, Xie Shuangquan ,   Shihezi University, China
Published: March 2024

The current study, the effectiveness of analyzing Glycyrrhiza uralensis for the treatment of COVID-19 was investigated using an integrated network pharmacology and molecular docking approach. Through network pharmacology, establishment of Protein-Protein Interactions (PPI), molecular docking simulations, GO analysis, and KEGG analysis, the aim was to investigate the mechanism of licorice in the treatment of COVID-19. There are 7 core genes corresponding to 3 bioactive compounds of G. uralensis. The target proteins of G. uralensis for the treatment of neocoronary pneumonia could be enriched to cancer pathway, lipid The target proteins of G. uralensis for the treatment of neocoronary pneumonia could be enriched to cancer pathway, lipid and atherosclerosis pathway, PI3K-Akt signaling pathway, and down-regulate the activity of core targets to inhibit the expression of virus SARS-CoV-2. Based on molecular docking simulations, the largest significant binding affinities were found for TNF and 7-Methoxy-2-methyl isoflavone (-6.95 kcal/mol), MAPK1 and kaempferol (-6.75 kcal/mol), and AKT1 and quercetin (-6.74 kcal/mol). Quercetin induces viral cell cycle arrest and inhibits growth and metastasis by engaging in the induction and expression of key intracellular targets. The flavonoid chemicals of kaempferol can inhibit inflammation-related signaling pathways and suppress the release of inflammation-related factors, and 7-methoxy-2-methylisoflavone may have therapeutic effects on COVID-19 by reducing hydroxyproline levels to suppress lung inflammation and fibrosis indices and modulate immune function. This suggests that G. uralensis has an interfering effect on novel coronaviruses and its main active component has a strong binding ability to the core gene of SARS-CoV-2, providing knowledge for future studies based on COVID-19.
Is the Patient State Index Recorded with the Sedline Sedation Monitor Correlated with the Duration of Emergence after Pediatric Surgery: An Exploratory, Single-Center, Blinded, Prospective Cohort Study
Authors:   Department of Anesthesiology, Cooper University Hospital, One Cooper Plaza, Camden, NJ 08103, USA, L Mitrev , S Pasch ,   Department of Anesthesiology, Cooper University Hospital, One Cooper Plaza, Camden, NJ 08103, USA, I Brotman ,   Department of Anesthesiology, Cooper University Hospital, One Cooper Plaza, Camden, NJ 08103, USA, B Gourkanti ,   Department of Anesthesiology, Cooper University Hospital, One Cooper Plaza, Camden, NJ 08103, USA, F Habib ,   Department of Anesthesiology, Cooper University Hospital, One Cooper Plaza, Camden, NJ 08103, USA, M Schwartz ,   Department of Anesthesiology, Cooper University Hospital, One Cooper Plaza, Camden, NJ 08103, USA, N van Helmond ,   Cooper Medical School of Rowan University, 401 Broadway, Camden, NJ 08103, USA
Published: March 2024

Introduction: Following surgery with general anesthesia, some children experience a prolonged emergence. We designed a prospective observational study in children undergoing general anesthesia who were monitored with the SedLine® Sedation Monitoring system (Masimo Corporation, Irvine, CA) to explore the hypothesis that the Patient State Index (PSI) obtained with this monitor could be inversely correlated with the duration of emergence after anesthesia. Materials and Methods: Prospective, observational single center study in a tertiary academic center in the United States. Fifty-six children between the ages of 1 and 12 years scheduled to undergo non-emergent surgery with general inhalational anesthesia were enrolled. Demographic and intraoperative characteristics were recorded. All caregivers were blinded to the PSI. Correlations were derived between PSI, duration of emergence, post-anesthesia care unit Length of Stay (LOS), and hospital LOS. PSI was analyzed in categories of <25, 25-50, and >50 both as absolute time spent in each category, and as the fraction of time compared to the length of the anesthetic. The development of Emergence Delirium (ED) was recorded as a secondary outcome variable. Results: The correlation coefficients between the PSI categories and the outcomes were weak (<0.3). Only two of the correlation coefficients reached statistical significance at p=0.05: fraction and absolute time spent in PSI category >50 and PACU length of stay, indicating that longer periods of PSI >50 during the anesthetic were associated with longer PACU LOS. Three patients (5%) developed ED. Conclusion: PSI measured with the SedLine monitor was not significantly correlated with the duration of emergence. There was a weak positive correlation between intraoperative time spent with PSI readings >50 and PACU LOS. Our sample did not have a high-enough event rate of ED to make statistical inferences about a correlation between PSI, ED and duration of emergence.
Double Needle Technique-A Novel Approach of Anaesthesia for Thoracolumbar Spine Fractures
Authors:   Rohilkhand Medical College, Bareilly, UP, India, Chandra Richa , Pullano Carmine ,   Consultant Anaesthesiologist, Casa di cura privata Villa, Pia Roma, Italy, Misra Gaurav ,   Associate Professor, Sri Ram Murti Smarak Institute of Medical Sciences, Bareilly, UP, India, Agrawal Pallav ,   Consultant Neurosurgeon, GD Hospital, Bareilly, UP, India, Singh Alok ,   Consultant Orthopedician, GD Hospital, Bareilly, UP India
Published: March 2024

Background: spinal fractures are associated with significant morbidity and mortality. Spinal decompression along with pedicle screw fixation is the standard line of treatment. General anaesthesia is considered as gold standard for these procedures but regional anaesthesia has its own set of advantages. We introduced dual needle technique for spinal anaesthesia to overcome the effect of regression of block with added advantage of low volume of local anaesthetics providing stable hemodynamics.
Unexpected Effects of Surfactant Adsorption Upon Water/Vapor Surface Geometry and Fluctuations
Authors: Kumar Nitesh , Clark Aurora
Published: March 2024

As described by capillary wave theory, adsorbates at a water/vapor interface change surface geometry and fluctuations through altered surface tension. Detailed theoretical studies of surface geometry in the presence of adsorbates, specifically amphiphilic surfactants are relatively sparse and many applications have focused upon ensemble average surface geometric characteristics. In this work we demonstrate that different interpretations of surface geometry emerge when considering the distributions of the geometric descriptors of surface curvature and orientation as a function of adsorbed surfactant concentration and sterics. Molecular dynamics simulations of tributyl phosphate (TBP) adsorbed to the water/vapor surface indicate that increased surface coverage homogeneously enhances symmetric sharp surface waves until a critical concentration is reached that is concomitant with TBP self-assembly. Thereafter, the convexity and concavity of the surface stop cancelling one another and skewing of the surface geometry metric distributions is increased. We define this as a homogeneous $\rightarrow$ inhomogenous surface geometry transition. Examining the surface geometry as a function of alkyl chain length reveals that smaller surfactants at surface coverages below that needed for surfactant-surfactant interactions \textit{inhomogenously} enhance surface curvature on the surface and that adsorbed alkyl tails to the surface can stabilize and increase homogeneous distributed surface geometric metrics. We label this an inhomogenous $\rightarrow$ homogeneous geometric transition. These results reflect the opportunity to incorporate more realistic distributions of surface geometry within the collective understanding of capillary wave theory and the relationship between surface geometry and macroscopic properties like surface tension.
Tight regulation of a nuclear HAPSTR1-HUWE1 pathway essential for mammalian life
Authors: Amici David R , Alhayek Sammy , Klein Austin T , Wang Yi-Zhi , Wilen Anika P , Song Weimin , Zhu Pei , Thakkar Abhishek , King McKenzi A , Steffeck Adam WT , Alasady Milad J , Peek Clara , Savas Jeffrey N , Mendillo Marc L
Published: March 2024

The recently discovered HAPSTR1 protein broadly oversees cellular stress responses. This function requires HUWE1, a ubiquitin ligase that paradoxically marks HAPSTR1 for degradation, but much about this pathway remains unclear. Here, leveraging multiplexed proteomics, we find that HAPSTR1 enables nuclear localization of HUWE1 with implications for nuclear protein quality control. We show that HAPSTR1 is tightly regulated and identify ubiquitin ligase TRIP12 and deubiquitinase USP7 as upstream regulators titrating HAPSTR1 stability. Finally, we generate conditional Hapstr1 knockout mice, finding that Hapstr1-null mice are perinatal lethal, adult mice depleted of Hapstr1 have reduced fitness, and primary cells explanted from Hapstr1-null animals falter in culture coincident with HUWE1 mislocalization and broadly remodeled signaling. Notably, although HAPSTR1 potently suppresses p53, we find that Hapstr1 is essential for life even in mice lacking p53. Altogether, we identify novel components and functional insights into the conserved HAPSTR1-HUWE1 pathway and demonstrate its requirement for mammalian life.
On the Stay of the Social Democratic Faction Deputies of the Second State Duma in Siberian Exile
Authors:   Irkutsk State University, Ivanov A. A. , Kruzhalina A. A. ,   Irkutsk State University
Published: March 2024

The reader is offered a description of the life and activities, including political ones, of the exiled deputies of the Social Democratic faction of the II State Duma of the Russian Empire. The article is based on the materials of the National Archive of the Irkutsk Region, as well as memoirs and reference literature published by the All-Union Society of Political Prisoners and Exiled Settlers. In the course of the research, the basic information characterizing the stay of the deputies of the “second-thinkers” in Siberian exile was identified and systematized; The main conclusions about the peculiarities of the socio-political and educational activities of former deputies in exile are formulated.
Study on phytochemical properties and antioxidant activities of marine macroalgae Padina tetrastromatica Hauck
Authors: T V Amitha , Aleena B. Eluvathingal  , J Carolin Joe Rosario , S Vimal Priya
Published: March 2024

An abundance of beneficial plant life can be found in aquatic areas, particularly in marine ecosystems. These resources have, therefore, been in use for hundreds of years. Seaweeds have long been closely associated with human life as a source of food, fodder, fine chemicals, fertilizer and pharmaceutically significant drugs. Algae are an important group of organisms with the largest source of biogenic compounds. They are found to possess significant antioxidant and phytochemical activities. The aim of the present study was to investigate the phytochemical and antioxidant activity of active compounds present in the methanol extract of the brown algae, Padina tetrastromatica Hauck. The antioxidant activity of extracts was evaluated by DPPH scavenging activity and Hydroxyl radical-scavenging activity assays. The phytochemical analysis revealed the presence of alkaloids, flavonoids, steroids, saponins, carbohydrates, proteins and phenolic compounds etc.
A comprehensive survey of cloud computing, encompassing architectures, data storage, services, security, and applications
Authors: Joslin K.
Published: March 2024

Generally, enterprises store data in internal storage and establish firewalls to protect against intruders attempting to access the data. In cloud computing, data is stored in storage provided by service providers. Information privacy protection involves storing data in encrypted form. The cloud system is responsible for both storage and the encryption or decryption of data, allowing system administrators to access encrypted data and decryption keys. This capability poses a risk to information privacy as it enables unauthorized access to information. This survey discusses Data Storage in Cloud Computing, focusing on the concept of storing encryption and decryption services alongside the storage service. Additionally, the survey examines storage system architecture, security challenges, services, and user application systems to provide a comparison of various cloud models. In addition to the fundamental aspects of data storage and encryption, this survey delves into the evolving landscape of cloud computing, addressing the dynamic nature of storage system architectures. Enterprises increasingly rely on cloud service providers for scalable and flexible storage solutions, prompting a critical examination of the security challenges associated with this paradigm shift. The survey examines how storage services in different cloud models affect user applications and privacy. It stresses the importance of understanding cloud providers' services amidst evolving technology and growing threats. The study delves into trends like edge computing and distributed storage, evaluating their impact on cloud storage security. Overall, it aims to provide a comprehensive overview for enterprises and researchers to make informed decisions on data security in Cloud Computing.
A comprehensive analysis of security challenges in mobile cloud computing
Authors: Gururaj H. L.
Published: March 2024

The computing capability of mobile systems is enhanced by cloud computing. Mobile devices can rely on cloud computing to perform computationally intensive operations such as data mining and searching. Mobile cloud computing refers to the availability of cloud computing services in a mobile environment. It is a combination of mobile networks and cloud computing, providing optimal services for mobile users. The use of mobile cloud computing overcomes performance-related obstacles, such as bandwidth, storage capacity, and battery life, as well as environment-related issues like availability, scalability, and heterogeneity. Security threats have become obstacles in the rapid adaptability of the mobile cloud computing paradigm, and there is a significant risk associated with migrating storage and data processing from mobiles to clouds. User privacy and the integrity of data and applications are key concerns that most cloud providers prioritize. This paper reviews the concept of mobile cloud computing and the security issues inherent within the context of mobile applications and cloud computing. It analyzes and compares various possible approaches proposed by researchers to address security and privacy issues in MCC. Despite widespread adoption, challenges like interoperability and standardization persist. Ongoing efforts focus on establishing common protocols, while research explores integrating technologies like edge computing and AI to enhance mobile cloud capabilities. This paper examines the dynamic landscape of MCC, addressing security concerns and exploring advancements and challenges, contributing to ongoing discussions on optimization, security, and the future of mobile cloud computing. As the field continues to evolve, researchers are actively working on developing comprehensive frameworks that not only address current security challenges but also anticipate and mitigate emerging threats in the ever-changing landscape of mobile cloud computing.
Analysis of Cultivating Top Innovative Talents in Undergraduate Teaching Reform Under the “Four in One” Model
Authors: Zhang Yunning
Published: March 2024

In the current landscape, cultivating top-notch innovative talents stands as one of the paramount tasks for universities. To attain this objective, undergraduate teaching reform is deemed imperative. Among various approaches, the “Four in One” training model emerges as a prevalent method, aiming to furnish students with a holistic educational experience while nurturing their innovative abilities and critical thinking through the integration of four key components. Commencing from this objective, the integration of general education and professional education development is explored to ensure the seamless implementation of reform and developmental measures.
Analysis of the Resistance of Elderly Individuals Living Alone in Utilizing Self-Checkout Systems in Supermarkets
Authors: Guo Fugang
Published: March 2024

Research on the rejection of technology among elderly people who are living alone is still scarce, so qualitative research methods are used to supplement the lack of exploratory research. The research was conducted in Harbin, which ranks middle in terms of economic development in China, and a total of 8 respondents were interviewed. The results of the interview showed that older people lack emotional support, instrumental support, and competence, and have subjective biases. Furthermore, active resistance encompasses factors limited usage opportunities, underdeveloped technology, unfavorable reputation, inefficiency, ambiguous equipment placement, minimal interaction, inadequate product information, and absence of instructional manuals. Conversely, passive resistance, aside from subjective biases, signifies the elderly’s pessimistic outlook on life, including world-weariness, low motivation, lack of initiative, insecurity, fear of technology, cognitive decline, and apprehension about disrupting others’ efficiency by using machinery. Additionally, this study highlights two significant findings: firstly, older individuals proficient in self-checkout technology are willing to accompany their less tech-savvy counterparts through automated aisles to alleviate feelings of isolation; secondly, older adults are wary of approaching employees and strangers, suspecting them of intending to sell products or perpetrate scams rather than provide technical assistance.
Концептуально-доктринальний вимір ядерної політики США на початку 21 століття
Authors: Лимар Маргарита , Агєєва-Каркашадзе Вікторія
Published: March 2024

Статтю присвячено дослідженню еволюції доктринальних основ ядерної політики Сполучених Штатів з початку 2000-х років і до сьогодні. Актуальність статті обумовлена дестабілізацією сучасної міжнародної системи безпеки та загостренням регіональних конфліктів. Розглянуто основні концепції та документи, в яких відображено зовнішньополітичні настанови щодо ядерної безпеки адміністрацій Дж. Буша-мол., Б. Обами, Д. Трампа та Дж. Байдена. Здійснено їх порівняльний аналіз; визначено подібності та відмінності у підходах щодо реалізації концепції ядерного стримування різними адміністраціями. Стаття ґрунтується переважно на аналізі документальної бази та науково-аналітичних публікацій американських і західноєвропейських дослідників. Визначено, що події 11 вересня 2001 р. радикально вплинули на зовнішню політику США та змусили адміністрацію республіканця Дж. Буша-мол. віддати пріоритет прямим військовим діям над класичними дипломатичними методами та стримуванням, що призвело до посилення загрози ядерного розповсюдження. Натомість адміністрація демократа Б. Обами надала перевагу дипломатії, працювала над відновленням морального лідерства США та створенням світу, вільного від ядерної зброї. Не зважаючи на те, що кінцева мета Б. Обами залишилися у декларативній площині, США змогли зміцнити сили стримування та скоротити ядерний арсенал на користь його модернізації, яку підтримував і республіканець Д. Трамп. Проте, президент Д. Трамп зосередився також і на розвитку ядерної програми США, чим суттєво зашкодив ядерному стримуванню та режиму нерозповсюдження. Нарешті, чинний президент-демократ Дж. Байден повернувся до політики Б. Обами, однак, з огляду на сучасні виклики міжнародній безпеці, його адміністрація відкинула принцип незастосування ядерної зброї першими та концепцію «єдиної мети». Авторки дійшли висновку, що не зважаючи на різні способи реалізації зовнішньої політики зазначеними адміністраціями, курс на ядерне стримування не втратив своєї актуальності на доктринальному рівні. Чинний президент Дж. Байден покладається на стримуючий ефект ядерної зброї, а його політика, спрямована як на модернізацію ядерних сил, так і на посилення регіональної співпраці задля спільного протистояння сучасним викликам міжнародній безпеці, видається виваженою та послідовною.
Pelatihan English Verbs untuk Siswa SMK Negeri 5 Palu
Authors: Said Mawardin M , Rita Ferry , Syafar Anshari , Maghfira Maghfira , Mawardin Ibmasiah Wardatun Islamiyah , Mawardin Ide Ilmiah , Mawardin Ilmuislami
Published: March 2024

Pengabdian ini bertujuan untuk melatih para siswa dalam menggunakan English Verbs (Katakerja Bahasa Inggris). Mereka diharapkan bisa meningkatkan kosakata khususnya katakerja bahasa Inggrisnya sehingga mereka bisa membuat kalimat dan berkomunikasi dalam bahasa asing itu. Mereka dimotivasi untuk menguasai katakerja bahasa Inggris yang digunakan dalam aktivitas hariannya sehingga mampu berkomunikasi dalam bahasa internasional itu secara praktis. Target khususnya adalah siswa-siswi yang memiliki semangat untuk menambah English Verbs (Katakerja Bahasa Inggris) sehingga bisa menggunakannya secara berkesinambungan dan mempengaruhi teman-temannya dalam menggunakan kosakata bahasa Inggris itu dalam kalimat. Mereka dengan mudah berkomunikasi dalam bahasa global itu jika memiliki banyak kosakatanya. Mereka juga bisa menjadi pembelajar global. Metode komunikatif dipakai untuk mencapai tujuan itu. Hasilnya Pelatihan English Verbs untuk Siswa itu aman dan tertib. Cara Praktis Belajar Bahasa Inggris dijelaskan kepada mereka yang juga dilatih untuk meningkatkan kosakata itu dan menggunakannya dalam kalimat sehingga mereka bisa mempraktikkannya dan meningkatkannya walaupun belum lancar dalam membuat dan mengungkapkannya. Mereka diharapkan menguasai English Verbs itu berhubung semua kalimat bahasa Inggris pasti memiliki katakerja.
Pendampingan Pemanfaatan Media Sosial atau E-Commerce dalam Upaya Pengenalan Produk dan Peningkatan Penjualan
Authors: Satyawan Made Dudy , Triani Ni Nyoman Alit , Yanthi Merlyana Dwinda , Bhilawa Loggar , Aisyahturrahmi Aisyahturrahmi
Published: March 2024

Era digitalisasi memengaruhi perilaku usaha, tidak hanya pelaku usaha yang bisnis modelnya berubah dari cara-cara konvensional ke penggunaan teknologi informasi, tapi juga perilaku konsumen yang berbelanja melalui platform-platform media sosial atau e-commerce. Mitra pengabdian yang merupakan pelaku usaha UMKM dan badan pengelola BUMDes di Desa pada Kabupaten Bojonegoro, Jawa Timur, memiliki permasalahan dalam mengenalkan usaha dan produk atau jasa yang dihasilkan. Metode konvensional mengorbankan biaya pemasaran yang tidak sedikit dan berpeluang mengalami kegagalan, begitu pula modal yang dikeluarkan untuk sewa toko. Semakin meningkatnya pengguna handphone dan internet di Indonesia menjadi peluang dalam memperluas pasar dan pemasaran produk atau jasa yang dimiliki oleh mitra pengabdian. Pemanfaatan Media Sosial atau E-Commerce menjadi upaya pengenalan produk dan peningkatan penjualan usaha mitra. Metode pelaksanaan pengabdian yang dilaksanakan diantaranya Pembuatan Katalog Produk, Pemilihan dan Pelatihan Penggunaan Media Sosial atau E-Commerce
Design of Antipodal Vivaldi Antenna for Medical Imaging Application
Authors: Mahendra Daffa , Hakim Randy Ivanal , Endarko Endarko
Published: March 2024

The microwave imaging (MWI) system in medical applications is commonly used to detect abnormalities in the human body. The purpose of this study was to design an Antipodal Vivaldi Antenna (AVA) for medical imaging applications using MWI. The research method used is based on the AVA design simulation of the CST Studio Suite 2019 application using time and frequency domain methods, which has dimensions of 60x40 mm2 with an antenna structure that works in the frequency range of 6.3-9.6 GHz, the impedance for bandwidth is -10 dB, using Flame Retardant-4 (FR-4) thickness 1.6 mm (= 4.3, tan δ = 0.025) as substrate material. A linear array of antennas was utilized in the simulation, either with or without a phantom. The phantom options include an absence of a phantom (only antennas), a cube-shaped water phantom, and a water phantom containing an anomaly. The result of the simulation on the AVA design produces a bandwidth of 41.61%, a gain of 5.16 dB, a return loss of -26.73 dB, a Specific Absorption Rate (SAR) value of 0.26 W/kg and a graph of S-parameters (S21). It can be concluded that the MWI system using the AVA design in this study has the potential to properly detect the presence of anomalies.
Effectiveness of KTP-EL Services at the Bone Regency Population and Civil Registry Service
Authors: Maryadi Maryadi , Rahman Nawir
Published: March 2024

KTP-EL aims to simplify the community identification process, but in its implementation, there are still several technical and administrative obstacles that must be overcome by the relevant agencies. This research aims to determine the effectiveness of KTP-EL services at the Bone Regency Population and Civil Registry Service. This type of research is qualitative using a descriptive approach. Data collection techniques were carried out by means of observation, interviews, and documentation. The data analysis technique used consists of data collection, data presentation, data condensation, and drawing conclusions. The results of the research show that the KTP-EL service at the Population and Civil Registry Service of Bone Regency is running effectively, this can be seen from 1) the existence of KTP-EL service procedures which are a reference in providing services to the community; 2) discipline of service officers, such as attendance, use of uniforms, work ethics and use of service tools; 3) provide services in Population Administration matters without charging fees; and 4) provision of adequate facilities and infrastructure, such as a large service area, sufficient chairs, and other facilities such as parking and toilets to provide comfort to the public
The Influence of Digipos Aja Application Product Quality, Price, and Promotion on Customer Satisfaction in Makassar City
Authors: Widodo Ismu , Witjara Edi , Noviarisanti Siska , Siraj Muhammad Luthfi
Published: March 2024

Digipos Aja Telkomsel, in carrying out digital transformation, also makes innovations in the digital world, one of which is creating Digipos Aja. Based on Telkomsel's internal data for 2021, there are 532,538 Digipos Aja Telkomsel registrations. This study explores Digipos Aja application product quality, prices, and promotions impact on consumer satisfaction in Makassar City. Methodology, This study employs correlational research that utilizes statistical correlations to describe and measure the relationship between two or more variables with multiple regression method. Finding: This study suggests that all variables have valid values. While the results of hypothesis testing show that partially each variable has a significant influence and simultaneously the variable quality of the Digipos Aja application product, price, and promotion on consumer satisfaction in Makassar City. Which means that the three X variables have a significant influence to variable Y. Conclusion: Product quality, price, and promotion simultaneously affects consumer satisfaction in Makassar City and all of them are statistically significant. The higher quality level of  Digipos Aja product subsequently elevate consumer confidence level towards the product. Additionally, with high level of trust for Digipos Aja products, therefore consumers are able to select and create purchasing decisions for these products.
The Impact of Identity Politics in the 2017 DKI Elections on Anies’ Electability Ahead of the 2024 Presidential Election
Authors: Susilowati Dealina , Ridwan Ridwan
Published: March 2024

Indonesia is a heterogeneous country with a population that has different backgrounds, making it vulnerable to political identity. Identity politics is often an issue that attracts the attention of the public, one of which occurred in the DKI Jakarta elections in 2017. Anies, who is running for president in the 2024 election, certainly expects great support from the people of DKI Jakarta, as the community he once led. However, Anies could not escape the turmoil of identity politics in the 2017 elections. The level of electability of a prospective leader is considered important to gain vote support from the public. Researchers used the theory of identity politics and electability to determine indicators in this study. This study aims to determine whether there is an influence of identity politics in the 2017 DKI Jakarta elections on Anies' electability ahead of the 2024 presidential election. The population of this study is the people of DKI Jakarta with millennial age. The sample taken was 100 people using the Slovin formula. The method used in this research is quantitative in the form of a questionnaire. Data analysis was carried out with the IBM SPSS version 24 program. This study shows that all variables meet the validity criteria. The novelty of this research is that it examines the variables of identity politics and electability which produce data in the form of statistical figures. This study found that the identity politics of the 2017 DKI Jakarta elections had an effect on Anies' electability ahead of the 2024 presidential election.
Consumptive Behavior of Students: Analysis of Herbert Marcuse's Perspective
Authors: Nurlela Nurlela , Kamaruddin Syamsu A , Adam Arlin , Jumadi Jumadi
Published: March 2024

Human life in the post-modern era is characterized by very varied needs and has penetrated all levels of society, including students. In practice, students at the Faculty of Social Sciences and Law, Makassar State University tend to act excessively and prioritize desires over needs, for certain reasons. This must be addressed as soon as possible because students are a key element in the movement to stop the pressure from capitalist activities that have developed, not to become supporters in inheriting and expanding the capitalist system. Therefore, this research aims to determine the consumer behavior of students at the Faculty of Social Sciences and Law, Makassar State University. This type of research is qualitative descriptive research using Herbert Marcuse's theoretical approach. Data collection techniques, namely observation, interviews, and documentation. Researchers used source triangulation to ensure the validity of the data, where the data collected in this research was analyzed using theories related to the object of research, namely the consumer behavior of students at the Faculty of Social Sciences and Law, Makassar State University. The results of this research show that students at the Faculty of Social Sciences and Law at UNM tend to prioritize secondary needs solely to achieve inner satisfaction. In essence, a new form of control has been integrated within students, accompanied by various forms of repression. Apart from that, by using Herbert Marcuse's theory the author also found that students at the Faculty of Social Sciences and Law at UNM in the era known as Gen-Z have been influenced by the urge to fulfill their needs even by ignoring other aspects of their lives, including lectures.
The Effectiveness of Using E-Mail Applications in the Management of Incoming and Outgoing Letters at the Makassar Religious Education and Training Centre
Authors: Nasrullah Muh. , Riska Riska , Akib Haedar
Published: March 2024

The Effectiveness of the Use of E-Mail Applications in the Management of Incoming and Outgoing Letters at the Makassar Religious Education and Training Centre Office. The information contained in a letter is very useful in future decision making as well as evidence and accountability of an organization. This research is a type of descriptive research, aiming to determine the effectiveness of the use of e-mail applications in managing incoming and outgoing letters at the Makassar Religious Education and Training Centre office. The informants in this study were the head of the Makassar BDK office, 2 archivists in charge, 2 administrative drafting staff. Data collection techniques used are observation, interviews and documentation. Data analysis techniques used are data collection, data condensation, data presentation, and conclusion/verification
Improving the Activities and Learning Outcomes of Financial Accounting Through the Application of Model Numbered Heads Together
Authors: Nurmiati Nurmiati
Published: March 2024

Numbered Heads Together (NHT) is one of the new learning methods that is effectively applied in schools, where this model can train and motivate students in following the teaching and learning process in the classroom. T The design of this study is class action research (PTK).  The purpose of this study is to find out an overview of the application of the Numbered Heads Together (NHT) model so that it can improve the activities and learning outcomes of Financial Accounting class XI AKL 1 SMK Negeri 2 Palu for the 2021/2022 Academic Year.  The research design follows the Kemmis & Mc Taggart model. This study uses 2 cycles and each cycle consists of 4 stages, namely: Planning, Implementation, Observation, and Reflection. Of the 30 students in cycle I, the criteria for Active participated in learning as many as 18 people (60%), Moderately Active 8 people (26.67%), Inactive as many as 4 people (13.33%). Based on the test results and observation results that have been carried out, this PTK only reaches cycle II because the criteria for individual absorption of 70 and classical completion of at least 85% have been achieved, namely 93.33%. The average teacher's teaching and learning activities have been "Good" and the average student has been "Active" following the learning.
The Influence of Internships on the Development of Soft Skills of Office Administration Education Students
Authors: Saleh Sirajuddin , Lala Lala , Darwis Muh.
Published: March 2024

This research was conducted to determine the effect of internships on the development of soft skills of Office Administration Education Students, Faculty of Social Sciences and Law, Makassar State University. The population in this study was 95 people and the sample was 95 people. While the data analysis techniques used are descriptive statistics using percentages and for inferential statistical analysis techniques using data normality tests, moment product correlation analysis, simple line ar regression analysis andpartial t tests.  From the test results show that the indicators of the internship variable are in the very good category while the learning motivation variable is in the very high category. Based on the results of the product moment correlation analysis, there is a relationship between the two variables. So it can be concluded that there is a significant influence between internships on the development of soft skilss Office Administration Education Students of the Faculty of Social Sciences and Law, Makassar State University
Improving Student Learning Outcomes Through the Think Pair and Share Model in Chemistry Learning
Authors: Srinadi Ni Putu
Published: March 2024

Think Pair and Share learning is a way of learning designed for students so they can be pushed into the flow of interaction and communication. Think Pair and Share was first developed by Frank Lyman and his colleagues at the University of Maryland in 1985. Therefore, it aims to find out whether the Think Pair and Share model can improve learning outcomes in Chemistry class XI MIPA 1 SMAN 1 Sigi even semester of the 2022 academic year/ 2023 and to find out how to describe the application of the Think Pair and Share model so that it can improve learning outcomes in Chemistry class XI MIPA 1 SMAN 1 Sigi even semester of the 2022/2023 academic year. This study used classroom action research with research subjects being class XI MIPA 1 students with a total of 27 people consisting of 6 men and 21 women with data collection techniques, namely qualitative data and quantitative data. The results of this study indicate that the Think Pair and Share Model can improve learning outcomes in Chemistry class XI MIPA 1 SMAN 1 Sigi even semester of the 2022/2023 academic year because the highest score in cycle I is 100 as many as 1 person in cycle II the highest score increases to 100 as many as 4 people. The lowest score in cycle I was 50 for 2 people and in cycle II the lowest score was only 1 person who was worth 50
Improving Student Learning Outcomes Through the Snowball Throwing Model in Learning Public Relations Administration and Protocol at SMK Negeri 1 Barru
Authors: Hariani Hariani
Published: March 2024

Snowball is a snowball while Throwing means throwing. Overall, Snowball Throwing can be interpreted as throwing snowballs. Snowball Throwing is formed in groups represented by the group leader to get assignments from the teacher, then each student makes a question shaped like a ball (question paper) and then throws it to other students, each student answers the question from the ball they get. So the aim of this research is to determine whether the Snowball Throwing model can improve student learning outcomes in learning Public Relations and Protocol Administration for Class XII OTKP 3 SMK Negeri 1 Barru for the 2022/2023 academic year. The research method used is classroom action research. The research subjects were 33 students of class XII OTKP 3 SMK Negeri 1 Barru, consisting of 5 boys and 28 girls. The research procedures carried out are based on each cycle, namely planning, implementation, observation, and reflection. Types of data and data collection techniques use qualitative and quantitative data, where qualitative data is collected through observation and documentation. Meanwhile, quantitative data is collected through tests at the end of each cycle. Meanwhile, data analysis techniques use data reduction techniques, data presentation, and drawing conclusions. Data analysis techniques, namely qualitative and quantitative data analysis. The results of the research show that the snowball-throwing model can improve student learning outcomes in Public Relations and Protocol Administration learning for Class. In cycle I, learning management generally went well, but time management still needed to be improved. However, in cycle II learning management improved, and this had a positive impact on student learning completion
LEGAL ANALYSIS OF PARTNERSHIP AGREEMENTS BETWEEN OJEK COMPANIES ONLINE WITH MOTORCYCLE TAXI DRIVER ONLINE
Authors: Wibowo Nandito Kelvianto , Saputra Arikha
Published: March 2024

online motorcycle taxi is one of the businesses created from technological developments. Online motorcycle taxis themselves use a partnership agreement as an agreement between online motorcycle taxi companies and online motorcycle taxi drivers. In the partnership agreement between the MAXIM online motorcycle taxi company and MAXIM online motorcycle taxi drivers, the agreement made is a standard agreement which does not give the driver any other choice, which is in conflict with the terms of the agreement. Therefore, this study aims to look at the course of the partnership between the MAXIM online motorcycle taxi company and MAXIM online motorcycle taxi drivers and the legal protection provided in the MAXIM partnership agreement using normative juridical research methods with descriptive analytical specifications.The results of the research on the partnership agreement between online motorcycle taxi companies and online motorcycle taxi drivers are that MAXIM as the service provider company has previously made a partnership agreement and the agreement is a standard agreement where drivers cannot do anything in the contents of the agreement, in other words, they can only accept if want to be part of the MAXIM online motorcycle taxi driver partner where this is not in accordance with the terms of the legal agreement. The legal protection that MAXIM online motorcycle taxi drivers get is preventive legal protection and repressive legal protection. preventive legal protection is legal protection provided by the Indonesian government, while repressive legal protection is protection provided by MAXIM
Legal Aid and Human Rights : A Reflection
Authors: Chandra Alex
Published: March 2024

Humanity and Human Rights is a concern of mankind throughout the world. Therefore, the consequences if there is a violation of human rights anywhere in the world will be a concern for humans everywhere in this world. The difficulty that is faced with this "Human Rights" is that Human Rights have a different meaning for everyone. Historians, jurists, philosophers and theologians can differ in stating something that has significant implications for human rights, and all these differing opinions must be examined. Some parties will seek definitions of “Rights” and “Obligations” and of course “Freedoms”. Other parties will argue about whether humans have inherent rights that are inherent and rooted in every human being.
Highly Educated Black Americans Report Higher than Expected Perceived Job Demands
Authors: Hogan Tiffany , Mancia Amy , Ndiaye Kanah , Rodriguez Brenda , Najand Babak , Zare Hossein , Assari Shervin
Published: March 2024

Background: Educational attainment has well established and widely recognized the effects on employment conditions and job demands. However, the way in which educational attainment correlates with perceived job demands may be inconsistent across racial groups as suggested by Minorities’ Diminished Returns (MDRs). The aim was to test the moderating effect of race on the association between educational attainment and perceived job demands, particularly for Black and White individuals. Methods: This study was a cross-sectional analysis of MIDUS Refresher 1, including 1,232 Black and White adults over the age of 25 in the United States. Education attainment was the independent variable and perceived job demands was the dependent variable covariates. Linear regression was used for multivariate models. Results- We observed positive association between education and perceived job demands, however, statistical interaction between race and education suggested stronger positive associations for Black than White individuals. Conclusion: Being a highly educated Black professional in the United States equals high demand such increase stress is a risk factor of being a middle class black American. Innovated and bold market policies are required to solve this unfair dilemma.
Pelatihan Pembuatan Pori Busa (Pupuk Organik desa Bug-Bug Kecamatan Lingsar)
Authors: Rahman Taufik , Adyan M. Audi , Fathurrahman Fathurrahman , Ayuni Baiq Annisa Sulistia , Kartini Srikandi Ayu , Aulya Nur Hafizatun , Ersu Aulia Padhila , Nur’Azizah Yuni , Maswinda Maswinda , Salmiah Baiq Himayatussifa , Sideman Ida Ayu Oka Suwati
Published: March 2024

Bug-Bug Village, which is located in Lingsar District, West Lombok Regency, has the potential for regional development as an agricultural area, because apart from the agricultural area being 42% of the total village area, it is also recorded that 27.45% of the population works as farmers. As a farmer, the need for subsidized fertilizer is certainly very large. Unfortunately, the government's ability to provide subsidized fertilizer is only 37-42%. By studying these conditions, the ability of farmers to make their own organic fertilizer is really needed. The benefits of organic fertilizer on the health of production results, the health of the surrounding environment and also the health and welfare of farmers, is also the reason that supports the "socialization and practice of making organic fertilizer" program by participants of the Mataram University Real Work Lecture (KKN) in Bug-Bug Village. The result of this activity is that farmers have high enthusiasm for the work program, local Agricultural Field Extension Officers (PPL) give high appreciation for the program and hope for support in the coming period. The Head of Bug-Bug Village also expressed high appreciation and hoped that in the next period of KKN, they would prepare a packaging and marketing program for fertilizer products
HABILIDADES SOCIOEMOCIONAIS: ESCOLA X FAMÍLIA
Authors: Garcia Renata Oliveira , Souza Gabrielle Luize de , Beutler Marinaia Natani Mafra , Oliveira Isabel Cristina d'Avila
Published: March 2024

O principal objetivo deste material infantil de habilidades socioemocionais é desenvolver uma compreensão sólida e prática das emoções em conjunto com a família, através de atividades interativas e afetivas, que visam a promoção de relacionamentos saudáveis e um crescimento emocional equilibrado.
Ao alcançar esses objetivos, esperamos que as crianças possam crescer como indivíduos emocionalmente inteligentes, preparados para enfrentarem os desafios do mundo com confiança e empatia.
Declaration of Fumonisin as the Main Dangerous Mycotoxin Produced by Fusarium Species on Maize in Iran
Authors: Hossein Saremi
Published: March 2024

Our study showed Fusarium spp. can be the most important fungal pathogen of maize causing severe yield losses and producing fumonisins that concern human and animal damages. Actually, other mycotoxins such as aflatoxin contamination have become regular in maize but the appearance of fumonisins was more frequent. However, the fluctuation between years and regions can affect the severity of the infection and then fumonisin production level. This mycotoxin was defined as fumonisin B1, fumonisin B2 and fumonisin B3 with diverse actions. The level of production, concentrations, and damages of fumonisins were found in different locations of maize fields in Iran. However, the fumonisin contents of the isolated samples were more diverse than in other locations. Toxin composition and maximum values differ significantly throughout the climate conditions and maize cultivars. The resistance cultivar of maize against the Fusarium pathogen can be helpful in controlling fumonisin production on the field effectively.
Is there a Place for Klotho in Alzheimer’s disease?
Authors: Maria Isabel Saiz-Figuerez , Nava E , Galindo MF , Joaquin Jordan
Published: March 2024

Alzheimer’s disease, a major healthcare concern, lacks an effective pharmacological therapy to change its irreversible progression. In this work, we present Klotho, a protein associated with aging that is involved in the regulation of numerous physiological processes and is a serious candidate to be a pharmacological target to act on. Klotho’s mRNA has been found in neurons of a variety of brain regions (cortex, hippocampus). The best studied and prominent function of Klotho is as the co-receptor of fibroblast growth factor 23 (FGF23), through which Klotho controls renal phosphate excretion and vitamin D metabolism. Reduced serum levels of Klotho in mice have been associated with a shorter life expectancy and with numerous pathological conditions such as renal disease, vascular calcification, neurodegeneration, and others. Moreover, overexpression of Klotho leads to opposite effects resulting in increased survival rates. In this review we address different signaling pathways in which Klotho is involved in one way or another, focusing on those pathways that could serve as pharmacological targets to modify the evolution of Alzheimer’s disease. We describe how Klotho inhibits signaling cascades involved in cellular senescence, fibrosis, inflammation, and apoptosis all of which are mediated by tumor growth factor β (TGF- β), nuclear factor kappa K (NF- κ B), insulin-like growth factor 1 (IGF-1) or Wnt. We also highlight how Klotho is able to activate anti-inflammatory and antioxidant signaling pathways. Although there are no drugs that act specifically on Klotho, compounds currently on the market such as hormone-based drugs, pravastatin, losartan, fosinopril, and rapamycin have been shown to increase the expression of this protein and are also discussed.