bluuebunny/crossref_metadata_2025 huggingface dataset:
Major differences in glycosylation and fucosyltransferase expression in low-grade versus high-grade bladder cancer cell lines
Authors: Ezeabikwa Bernadette , Mondal Nandini , Antonopoulos Aristotelis , Haslam Stuart M , Matsumoto Yasuyuki , Martin-Caraballo Miguel , Lehoux Sylvain , Mandalasi Msano , Ishaque Ali , Heimburg-Molinaro Jamie , Cummings Richard D , Nyame Anthony K
Published: July 2021

Bladder cancer is the ninth most frequently diagnosed cancer worldwide, and there is a need to develop new biomarkers for staging and prognosis of this disease. Here we report that cell lines derived from low-grade and high-grade bladder cancers exhibit major differences in expression of glycans in surface glycoproteins. We analyzed protein glycosylation in three low-grade bladder cancer cell lines RT4 (grade-1-2), 5637 (grade-2), and SW780 (grade-1), and three high-grade bladder cancer cell lines J82COT (grade-3), T24 (grade-3) and TCCSUP (grade-4), with primary bladder epithelial cells, A/T/N, serving as a normal bladder cell control. Using a variety of approaches including flow cytometry, immunofluorescence, glycomics and gene expression analysis, we observed that the low-grade bladder cancer cell lines RT4, 5637 and SW780 express high levels of the fucosylated Lewis-X antigen (Lex, CD15) (Galβ1–4(Fucα1–3)GlcNAcβ1-R), while normal bladder epithelial A/T/N cells lack Lex expression. T24 and TCCSUP cells also lack Lex, whereas J82COT cells express low levels of Lex. Glycomics analyses revealed other major differences in fucosylation and sialylation of N-glycans between these cell types. O-glycans are highly differentiated, as RT4 cells synthesize core 2-based O-glycans that are lacking in the T24 cells. These differences in glycan expression correlated with differences in RNA expression levels of their cognate glycosyltransferases, including α1–3/4-fucosyltransferase genes. These major differences in glycan structures and gene expression profiles between low- and high-grade bladder cancer cells suggest that glycans and glycosyltransferases are candidate biomarkers for grading bladder cancers.
‘Clean, Fix, and Grant Splendor’: The Making of Diccionario de Autoridades
Authors: Stavans Ilan
Published: July 2021

Hailed as the foundation of modern Spanish-language lexicography, the Diccionario de Autoridades was developed over a period of thirteen years. While it is a window to appreciate the impact of Enlightenment ideas in Spain, it also showcases some of the country's most entrenched phobias, both within and throughout its colonies across the Atlantic. This essay looks at its planning, structure, and publication in political, cultural, and linguistic terms. It analyses its legacy over the Dicionario de la Lengua Española, which is the organ of the Real Academia Española and on other Spanish-language lexicons. And it compares it with the work of Samuel Johnson's A Dictionary of the English Language and Noah Webster's An American Dictionary of the English Language. The xenophobic motto of the Real Academia Española, ‘Clean, Fix, and Grant Splendor’, long a subject of controversy, is the philosophy behind Autoridades.
Alignment of the magnetic field in star-forming regions and why it might be difficult to observe
Authors: Girichidis Philipp
Published: July 2021

Magnetic fields are an important component of the interstellar medium (ISM) and exhibit strongly varying field strengths and a non-trivial correlation with the gas density. Its dynamical impact varies between individual regions of the ISM and correlates with the orientation of the field with respect to the gas structures. Using high-resolution magneto-hydrodynamical simulations of the ISM, we explore the connection between the orientation of the field and the dynamical state of the gas. We find that the onset of gravitational instability in molecular gas above a density of $\rho \sim 10^{-21}\, \mathrm{g\, cm}^{-3}$$(n\sim 400\, \mathrm{cm}^{-3})$ coincides with an alignment of the magnetic field lines and the gas flow. At this transition, the gradient of the density changes from mainly perpendicular to preferentially parallel to the field lines. A connection between the three-dimensional alignment and projected two-dimensional observables is non-trivial, because of a large dispersion of the magnetic field orientation along the line of sight. The turbulent correlation lengths can be small compared to the typical integration lengths. As a consequence, the small-scale signal of the orientation can sensitively depend on the line of sight or the dynamical state of the cloud can fluctuate stochastically or be completely averaged out. With higher spatial resolution more small-scale structures are resolved, which aggravates the link between magneto-hydrodynamical quantities and projected observables.
Open-system Evolution of a Crustal-scale Magma Column, Klamath Mountains, California
Authors: Barnes Calvin G , Coint Nolwenn , Barnes Melanie A , Chamberlain Kevin R , Cottle John M , Rämö O Tapani , Strickland Ariel , Valley John W
Published: July 2021

This study addresses the question of how and where arc magmas obtain their chemical and isotopic characteristics. The Wooley Creek batholith and Slinkard pluton are a tilted, mid- to upper-crustal part of a vertically extensive, late-Jurassic, arc-related magmatic system in the Klamath Mountains, northern California. The main stage of the system is divided into an older lower zone (c. 159 Ma) emplaced as multiple sheet-like bodies, a younger upper zone (c. 158–156 Ma), which is gradationally zoned upward from mafic tonalite to granite, and a complex central zone, which represents the transition between the lower and upper zones. Xenoliths are common and locally abundant in the lower and central zones and preserve a ghost stratigraphy of the three host terranes. Bulk-rock Nd isotope data along with ages and Hf and oxygen isotope data on zircons were used to assess the location and timing of differentiation and assimilation. Xenoliths display a wide range of εNd (whole-rock) and εHf (zircon), ranges that correlate with rocks in the host terranes. Among individual pluton samples, zircon Hf and oxygen isotope data display ranges too large to represent uniform magma compositions, and very few data are consistent with uncontaminated mantle-derived magma. In addition, zoning of Zr and Hf in augite and hornblende indicates that zircon crystallized at temperatures near or below 800 °C; these temperatures are lower than emplacement temperatures. Therefore, the diversity of zircon isotope compositions reflects in situ crystallization from heterogeneous magmas. On the basis of these and published data, the system is interpreted to reflect initial MASH-zone differentiation, which resulted in elevated δ18O and lowered εHf in the magmas prior to zircon crystallization. Further differentiation, and particularly assimilation–fractional crystallization, occurred at the level of emplacement on a piecemeal (local) basis as individual magma batches interacted with partial melts from host-rock xenoliths. This piecemeal assimilation was accompanied by zircon crystallization, resulting in the heterogeneous isotopic signatures. Magmatism ended with late-stage emplacement of isotopically evolved granitic magmas (c. 156 Ma) whose compositions primarily reflect reworking of the deep-crustal MASH environment.
Patronage and Predominance: How the LDP Maintains Its Hold on Power
Authors: REED Steven R
Published: July 2021

The Liberal Democratic Party (LDP) held power from 1955 until 1993. How did it manage to do so? In 1994 a political reform resulted in competitive elections but, starting in 2012, the LDP regained its predominant position, winning three consecutive landslide victories. How did it manage to do this even after the reform? In this paper I argue that a system of ‘party-organization patronage’, in which the patron is the LDP and the client is an interest group organization, played a significant role in maintaining LDP predominance in both periods. I further argue that the key to explaining changes in the predominant party system is the LDP’s monopoly on access to the public policy making process. When this monopoly faltered, interest group organizations began to put a foot in both camps or even defected to an opposition party but once the LDP’s monopoly was re-established interest groups returned to the LDP fold. In both cases, predominance was established in two steps. First, fortuitous events gave the LDP an overwhelming parliamentary majority and a monopoly on access to policy making. Second, the LDP granted organizations access to policy making in exchange for their votes which helped it maintain its monopoly.
Genetic parameter estimates for bull prolificacy and its relationship with scrotal circumference in a commercial beef cattle population
Authors: Russell Chad A , Pollak E John , Spangler Matthew L
Published: July 2021

The commercial beef cattle industry relies heavily on the use of natural service sires. When artificial insemination is deemed difficult to implement, multisire breeding pastures are used to increase reproductive rates in large breeding herds or to safe-guard against bull injury during the breeding season. Although each bull might be given an equal opportunity to produce offspring, evidence suggest that there is substantial variation in the number of calves sired by each bull in a breeding pasture. With the use of DNA-based paternity testing, correctly assigning calves to their respective sires in multisire pastures is possible and presents an opportunity to investigate the degree to which this trait complex is under genetic control. Field data from a large commercial ranch was used to estimate genetic parameters for calf count (CC; 574 records from 443 sires) and yearling scrotal circumference (SC; n = 1961) using univariate and bivariate animal models. Calf counts averaged 12.2 ± 10.7 and SC averaged 35.4 ± 2.30 cm. Bulls had an average of 1.30 records and there were 23.9 ± 11.1 bulls per contemporary group. The model for CC included fixed effects of age during the breeding season (in years) and contemporary group (concatenation of breeding pasture and year). Random effects included additive genetic and permanent environmental effects, and a residual. The model for SC included fixed effects of age (in days) and contemporary group (concatenation of month and year of measurement). Random effects included an additive genetic effect and a residual. Univariate model heritability estimates for CC and SC were 0.178 ± 0.142 and 0.455 ± 0.072, respectively. Similarly, the bivariate model resulted in heritability estimates for CC and SC of 0.184 ± 0.142 and 0.457 ± 0.072, respectively. Repeatability estimates for CC from univariate and bivariate models were 0.315 ± 0.080 and 0.317 ± 0.080, respectively. The estimate of genetic correlation between CC and SC was 0.268 ± 0.274. Heritability estimates suggest that both CC and SC would respond favorably to selection. Moreover, CC is lowly repeatable and although favorably correlated, SC appears to be weakly associated with CC.
Association Between USMLE Step 1 Scores and In-Training Examination Performance: A Meta-Analysis
Authors: Panda Nikhil , Bahdila Dania , Abdullah Abeer , Ghosh Auyon J. , Lee Sun Yeop , Feldman William B.
Published: July 2021

Purpose

On February 12, 2020, the sponsors of the United States Medical Licensing Examination announced that Step 1 will transition to pass/fail scoring in 2022. Step 1 performance has historically carried substantial weight in the evaluation of residency applicants and as a predictor of subsequent subject-specific medical knowledge. Using a systematic review and meta-analysis, the authors sought to determine the association between Step 1 scores and in-training examination (ITE) performance, which is often used to assess knowledge acquisition during residency.

Method

The authors systematically searched Medline, EMBASE, and Web of Science for observational studies published from 1992 through May 10, 2020. Observational studies reporting associations between Step 1 and ITE scores, regardless of medical or surgical specialty, were eligible for inclusion. Pairs of researchers screened all studies, evaluated quality assessment using a modified Newcastle-Ottawa Scale, and extracted data in a standardized fashion. The primary endpoint was the correlation of Step 1 and ITE scores.

Results

Of 1,432 observational studies identified, 49 were systematically reviewed and 37 were included in the meta-analysis. Overall study quality was low to moderate. The pooled estimate of the correlation coefficient was 0.42 (95% confidence interval [CI]: 0.36, 0.48; P < .001), suggesting a weak-to-moderate positive correlation between Step 1 and ITE scores. The random-effects meta-regression found the association between Step 1 and ITE scores was weaker for surgical (versus medical) specialties (beta –0.25 [95% CI: –0.41, –0.09; P = .003]) and fellowship (versus residency) training programs (beta –0.25 [95% CI: –0.47, –0.03; P = .030]).

Conclusions

The authors identified a weak-to-moderate positive correlation between Step 1 and ITE scores based on a meta-analysis of low-to-moderate quality observational data. With Step 1 scoring transitioning to pass/fail, the undergraduate and graduate medical education communities should continue to develop better tools for evaluating medical students.
When Faculty Tell Tales: How Faculty Members’ Reflective Narratives Impact Residents’ Professional Identity Formation
Authors: Khoo See Meng , Wong Xin Lin Serene
Published: July 2021

Problem

Most training programs have focused on the explicit teaching of professionalism, an approach that has seen limited success, to transform trainees into physicians. It is possible that faculty members’ reflective narratives, if appropriately shared with trainees, can facilitate the processes of reflection and socialization and help shift the training paradigm toward supporting professional identity formation.

Approach

In May 2010, an online forum, where faculty could share personal reflective narratives with all residents and faculty via email, was created for the National University Health System’s internal medicine residency program. By 2016, 40 letters had been written and nearly 200 residents and 30 faculty members had read these. This repository of faculty members’ reflective narratives touches on a broad range of issues related to professionalism, including altruism, humanism, excellence, and accountability. In February 2017, the authors conducted semistructured focus group discussions with 20 residents to explore the impact of faculty members’ reflective narratives on their professional identity development.

Outcomes

Residents reported that narratives, if written by authors who were recognized as role models, triggered the processes of reflection and socialization; were more effective in provoking reflection if they resonated with residents’ experiences; inspired them to follow how their role models reflected on and coped with challenges; and influenced the culture of the workplace, impacting the residents’ daily experiences and leading to socialization and development of their professional identity.

Next Steps

These early observations on the role of faculty members’ reflective narratives highlight the importance of credible role models, the daily work experience, and the culture of the workplace and provide information educators could use to more effectively support trainees’ professional identity formation as they design curricula. Among other things, future studies should explore the role and effectiveness of faculty members’ reflective narratives in different educational contexts.
From emergency department to operating room: interventional analgesia techniques for hip fractures
Authors: Garip Levin , Balocco Angela L. , Van Boxstael Sam
Published: July 2021

Purpose of review

To provide an update on pain management options with regional anesthesia for patients with hip fractures at the emergency department (ED).

Recent findings

Patients who sustain a hip fracture are typically admitted and diagnosed in the ED before being transferred to the operating room for surgery. Studies have clearly demonstrated the ability of the fascia iliaca compartment blocks (FICBs) and femoral nerve blocks (FNBs) to reduce pain and the risk of an acute confusional state. Their administration at an early stage of the patient's trajectory in the ED is beneficial. Recent anatomical studies contributed new knowledge of nociception in the hip joint, which allowed the development of more specific infiltration analgesia techniques without muscle weakness (e.g., pericapsular hip blocks). Further research on the timing of nerve blocks and an evaluation of new motor sparing techniques is indicated.

FICB and FNB are established and recommended techniques in pain management for hip fracture patients. Their use early on in the ED may improve patient comfort and outcome. Pericapsular nerve hip blocks could provide a relevant alternative in future pain management in this group of patients.
Acupressure and Acupuncture Use in the Peripartum Period
Authors: Atkins Kristin L. , Fogarty Sarah , Feigel Melissa L.
Published: July 2021

Acupuncture is the procedure of inserting fine needles into specific points on the body for therapeutic purposes. Acupuncture and its derivatives (acupressure, moxibustion, electroacupuncture, and transcutaneous electric nerve stimulation on acupoints) are a popular treatment choice in the peripartum period (32 wk’ gestation to 14 d postdelivery). There is substantial research evidence supporting acupuncture and its derivatives in the peripartum period. Benefits in the use of acupressure to reduce labor pain intensity and a reduction in the duration of labor with acupressure have been found. There is mixed evidence for the use of both moxibustion and moxibustion with acupuncture for noncephalic presentations and for acupressure for reducing intraoperative nausea. There is limited evidence available on acupuncture use in women with high-risk pregnancies or multifetal gestations.
Female Genital Cutting: An Evidence-based Review for the OBGYN of Long-term Sequelae and Management Options
Authors: Shahawy Sarrah , Nour Nawal M.
Published: July 2021

Female genital cutting (FGC) is a persisting global practice that increases patients’ risk for experiencing long-term health sequelae. Existing meta-analysis evidence strongly supports an association between FGC and the development of long-term dyspareunia, urinary tract infections, and sexual dysfunction as well as increased risk obstetrically of prolonged labor, cesarean section, perineal lacerations, and episiotomy. Surgical defibulation is recommended in patients with type III FGC to decrease obstetric and gynecologic morbidity. Existing evidence does not seem to definitively support clitoral reconstructive surgery. More research is needed to study conservative treatment and management approaches to long-term sequelae of FGC.
Is an Antenatal Screening for Chlamydia trachomatis Necessary in the Current Society?
Authors: Dorado Criado Marta , Fabra Garrido Celia , Merino San Martín Elena , González Arboleya Carolina , Gómez-Arroyo Bartolomé , González-Donapetry Patricia , Baquero-Artigao Fernando , de la Calle María , Quiles-Melero Inmaculada , Calvo Cristina
Published: July 2021

A screening of Chlamydia trachomatis infection in young pregnant women (≤25 years old) and their newborns was conducted. A total of 136 women were tested with urine samples in the immediate postpartum period. The prevalence was 18.4% (95% confidence interval [CI]: 11.9–24.9%) (25/136) and the rate of perinatal transmission was 35% (7/20). These results support the need for antenatal screening programs in high-risk women in Madrid (Spain).
Health-related Quality of Life After Childhood Bacterial Meningitis
Authors: Rugemalira Emilie , Karppinen Mariia , Savonius Okko , Cruzeiro Manuel Leite , Peltola Heikki , Roine Irmeli , Pelkonen Tuula
Published: July 2021

Background:

Survivors of bacterial meningitis (BM) often suffer from impaired quality of life that stems from disabling sequelae. The authors aimed to estimate health-related quality of life (HRQOL) and the influence of neurologic and audiologic sequelae among pediatric BM survivors.

Methods:

Survivors of 2 BM treatment trials at Luanda Children’s Hospital, Angola were evaluated for severity of disability via the modified Glasgow Outcome Scale, which considers neurologic and audiologic sequelae. Children who received vaccinations at the hospital during the time of the study (1–2, 2017) and survivors’ siblings served as controls. The Pediatric Quality of Life Inventory tool (PedsQL) enabled identifying HRQOL disparities between the cases and controls.

Results:

In all, 68 BM survivors (median time since BM: 28 months) and 35 controls participated. Survivors scored significantly lower than controls per PedsQL parent-proxy reports, indicating lower HRQOL (physical health: 82.5 vs. 100, P = 0.001; psychosocial health: 80 vs. 90, P = 0.005; and total score: 82.61 vs. 93, P = 0.004), while no difference prevailed between cases and controls in PedsQL child self-reporting. In all Glasgow Outcome Scale classes, cases differed significantly from controls in PedsQL parent-proxy reporting terms, with total scores of 84.21 (mild/no disability), 43.54 (moderate disability) and 55.56 (severe disability), while the controls scored 91.3 (P = 0.04, P = 0.02 and P < 0.001, respectively).

Conclusions:

Irrespective of possible disability, BM survivors’ HRQOL is impaired, according to parents’ perceptions. There is a need to facilitate follow-ups for all BM survivors, to enable timely rehabilitation when needed.
Correlation of the Corvis Biomechanical Factor with tomographic parameters in keratoconus
Authors: Flockerzi Elias , Vinciguerra Riccardo , Belin Michael Wellington , Vinciguerra Paolo , Ambrósio Renato , Seitz Berthold
Published: July 2021

Purpose:

To investigate the relationship between corneal biomechanics and keratoconus (KC) severity as described by tomographic parameters.

Setting:

University-based German ophthalmology department.

Design:

Retrospective cross-sectional study.

Methods:

A total of 448 KC corneas of the Homburg Keratoconus Center and 112 healthy corneas (448+112 patients) were examined by Pentacam high-resolution and Corneal Visualization Scheimpflug Technology (Pentacam HR and Corvis ST). The KC population included a wide spectrum of disease severity based on Belin's ABCD classification. Linear regression analysis was performed between the linear term of the Corvis Biomechanical Index (CBI) (CBI beta) and the tomographic values anterior radius of curvature (ARC), posterior radius of curvature (PRC), and thinnest corneal thickness (TCT). A linear transformation of the CBI beta was performed to provide an intuitive scaling, which was referred to as the Corvis Biomechanical Factor (CBiF = −0.24294226 × CBI beta + 6.02). This scaling adjusted the CBI beta to the same scale as posterior corneal curvature (PRC).

Results:

There was a high correlation of the CBI beta and its modification, the CBiF, with TCT (Pearson, r = −0.775), ARC (r = −0.835), and PRC (r = −0.839) in the KC population (P < .001). In the control corneas, the correlation between the CBI beta and ARC was weak (r = −0.216, P = .022), not significant (PRC, r = −0.146, P = .125), or moderate (TCT, r = −0.628, P < .001).

Conclusions:

The linear term of the CBI was highly associated with KC severity as defined by corneal tomography. The CBiF represents a new scale based on biomechanical characteristics in KC, which could serve as a basis for a biomechanical KC classification in the future.
Comparison of refractive and visual outcomes of 3 presbyopia-correcting intraocular lenses
Authors: Ferreira Tiago B. , Ribeiro Filomena J. , Silva Diana , Matos Ana Cláudia , Gaspar Sylvia , Almeida Soraia
Published: July 2021

Purpose:

To evaluate and compare the clinical outcomes after cataract surgery with implantation of 3 types of trifocal diffractive intraocular lenses (IOLs).

Setting:

Hospital da Luz, Lisbon, Portugal.

Design:

Prospective comparative case series.

Methods:

Patients undergoing phacoemulsification cataract surgery with implantation of 1 of the 3 trifocal IOLs were enrolled: TECNIS Synergy (Synergy group, 30 patients), Acrysof PanOptix (PanOptix group, 30 patients), and POD F (Finevision group, 30 patients). The outcomes of distance, intermediate, and near visual acuity (VA), refraction, defocus curve, photic phenomena, and spectacle independence were evaluated at the 3-month follow-up.

Results:

180 eyes of 90 patients were enrolled. No statistically significant differences were found between groups in monocular distance-corrected intermediate (Synergy group 0.04 ± 0.11, PanOptix group 0.05 ± 0.09, and Finevision group 0.08 ± 0.10; P = .107) and near VA (0.01 ± 0.08, 0.01 ± 0.06, and 0.04 ± 0.10, respectively; P = .186). Similarly, no statistically significant differences among groups were found in binocular uncorrected distance (P = .572), near (P = .929), and intermediate VA (P = .327). By contrast, statistically significant differences between groups were found in the visual acuity for the vergence demands of −0.50, −1.00, −2.00, −3.50, and −4.00 diopters (P ≤ .045). No statistically significant differences among groups were found in the frequency, severity, and bothersomeness of different disturbing visual symptoms, including glare and halos (P ≥ .129). More than 87 (96%) of patients in all groups did not require the use of spectacles at any distance postoperatively.

Conclusions:

The 3 trifocal IOLs evaluated provided an effective visual rehabilitation with minimal incidence of photic phenomena. A trend to obtain a wider range of functional focus was observed with the TECNIS Synergy IOL.
A Novel Nomogram for Predicting Poor 6-Month Function in Patients With Acute Ischemic Stroke Receiving Thrombolysis
Authors: Huang Lihong , Li Feng , Huang Cheng , Luo Yetao , Liu Guangwei
Published: July 2021

Background

Patients with acute ischemic stroke (AIS) receiving thrombolysis with good function at discharge are usually ignored. Their functional deterioration after discharge not only compromises the effectiveness of thrombolytic therapy but also reduces their long-term quality of life, which is not conducive to the advancement of medical healthcare and continuing care.

Objective

The aims of this study were to explore the risk factors for poor 6-month function in patients with AIS receiving thrombolysis with good function at discharge and construct a novel nomogram model.

Methods

This case-control study retrospectively analyzed the medical data of 149 patients with AIS receiving thrombolysis with good function at discharge from January 2017 to June 2019. Patients were divided into a poor function group (<3 points) and a good function group (≥3 points) according to their modified Rankin Scale scores at 6 months. Logistic regression was used to identify risk factors for poor 6-month function. A novel nomogram prediction model for poor 6-month function was constructed, and its prediction performance and concordance were evaluated.

Results

Of 149 patients, 21 (14%) had poor 6-month function and 128 (86%) had good 6-month function. Multivariate regression analysis showed that physical inactivity, neutrophil count, cerebral small vessel disease score, and hospitalization days were independent risk factors for poor 6-month function. A regression model was established according to the multivariate analysis, and the area under the curve was 0.9363. The accuracy was 71.99%, the sensitivity was 78.83%, and the specificity was 70.26%. A nomogram model was constructed, and its concordance index was 0.836 after internal validation.

Conclusion

The novel nomogram model facilitates risk prediction of poor 6-month function in patients with AIS receiving thrombolysis with good function at discharge and is helpful for making discharge plans.
Pediatric Surgery Rounding Checklists
Authors: Bawany Fatima , Bayer Nathaniel D. , Foito Theresa , Gleason Cassandra L. , Michels Julie A. , Philip Sherry S. , Pulhamus Marsha , Wakeman Derek S. , Schriefer Jan
Published: July 2021

Background

Inpatient surgical teams are challenged with treating complex patients, communicating across disciplines, educating trainees, and transitioning between the operating room, clinic, and inpatient unit. Systematic approaches to rounds are needed to perform these tasks effectively. Prior studies on nonsurgical units have shown that rounding checklists improve patient safety and trainee education. However, few studies have investigated the utility of checklists on surgical rounds.

Objective

The purpose of this article is to synthesize the evidence regarding rounding checklists on inpatient surgical units, with a focus on structure, content, utilization, outcomes, and educational value.

Methods

A narrative review was completed after a search of PubMed, Embase, and Cumulative Index of Nursing and Allied Health Literature in November 2020 using the following index terms and keywords: pediatrics, operative surgical procedures, surgery, perioperative period, teaching rounds, rounds, checklist, rounding tool, and rounding list.

Results

We identified 11 relevant studies. Six were conducted on inpatient surgical units (54%), and five were conducted on medicine or critical care units (46%). The structure and content of checklists were varied, with most integrating subjective and objective findings. These studies show that rounding checklists improve the organization and completeness of rounds, interdisciplinary communication, documentation, adverse event rates, and educational opportunities. However, they also increase rounding time and require reinforcement for sustained compliance.

Conclusions

The existing literature suggests rounding checklists can help create a culture of safety in which every team member, from nurse to attending, actively participates in improving patient care. We provide strategies to develop rounding checklists for pediatric surgical units.
Extracorporeal Life Support Organization (ELSO) Guidelines for Follow-up After Neonatal and Pediatric Extracorporeal Membrane Oxygenation
Authors: Ijsselstijn Hanneke , Schiller Raisa M. , Holder Christen , Shappley Rebekah K. H. , Wray Jo , Hoskote Aparna
Published: July 2021

Neonates and children who have survived critical illness severe enough to require extracorporeal membrane oxygenation (ECMO) are at risk for neurologic insults, neurodevelopmental delays, worsening of underlying medical conditions, and development of new medical comorbidities. Structured neurodevelopmental follow-up is recommended for early identification and prompt interventions of any neurodevelopmental delays. Even children who initially survive this critical illness without new medical or neurologic deficits remain at risk of developing new morbidities/delays at least through adolescence, highlighting the importance of structured follow-up by personnel knowledgeable in the sequelae of critical illness and ECMO. Structured follow-up should be multifaceted, beginning predischarge and continuing as a coordinated effort after discharge through adolescence. Predischarge efforts should consist of medical and neurologic evaluations, family education, and co-ordination of long-term ECMO care. After discharge, programs should recommend a compilation of pediatric care, disease-specific care for underlying or acquired conditions, structured ECMO/neurodevelopmental care including school performance, parental education, and support. Institutionally, regionally, and internationally available resources will impact the design of individual center’s follow-up program. Additionally, neurodevelopmental testing will need to be culturally and lingually appropriate for centers’ populations. Thus, ECMO centers should adapt follow-up program to their specific populations and resources with the predischarge and postdischarge components described here.
Surface Coatings for Rotary Ventricular Assist Devices: A Systematic Review
Authors: Zhang Meili , Tansley Geoffrey D. , Dargusch Matthew S. , Fraser John F. , Pauls Jo P.
Published: July 2021

Rotary ventricular assist devices (VADs) are frequently used to provide mechanical circulatory support to patients suffering from end-stage heart failure. Therefore, these devices and especially their pump impeller and housing components have stringent requirements on wear resistance and hemocompatibility. Various surface coatings have been investigated to improve the wear resistance or hemocompatibility of these devices. The aim of the present systematic review was to build a comprehensive understanding of these coatings and provide potential future research directions. A Boolean search for peer-reviewed studies was conducted in online databases (Web of Science, Scopus, PubMed, and ScienceDirect), and a preferred reporting items for systematic reviews and meta-analyses (PRISMA) process was followed for selecting relevant papers for analysis. A total of 45 of 527 publications were included for analysis. Eighteen coatings were reported to improve wear resistance or hemocompatibility of rotary VADs with the most common coatings being diamond-like carbon (DLC), 2-methacryloyloxyethyl phosphorylcholine (MPC), and heparin. Ninety-three percent of studies focused on hemocompatibility, whereas only 4% of studies focused on wear properties. Thirteen percent of studies investigated durability. This review provides readers with a systematic catalogue and critical review of surface coatings for rotary VADs. The review has identified that more comprehensive studies especially investigations on wear properties and durability are needed in future work.
Current approaches to reporting pharyngo-laryngeal secretions
Authors: Miles Anna , Hunting Alex , Fletcher Hannah , Allen Jacqueline E.
Published: July 2021

Purpose of review

Accumulated secretions in the pharynx and larynx are associated with dysphagia, aspiration and pneumonia, as well as increased social, health and economic burden. This article reviews developments in the instrumental reporting of pharyngo-laryngeal secretions over the last 2 years.

Recent findings

Although the healthy pharynx and larynx is moist, accumulation of secretions is indicative of abnormality. Using standardized secretion scales allows early identification, quantification of risk in patients, and sensitive monitoring of patients over time. Nonstandardized and subjective secretion reporting is common in recently published research despite the validation of a number of publicly available tools. Research characterizing accumulated secretions has contributed to our understanding of pathophysiology associated with poor secretion management and may inform future treatment studies.

Routine and standardized reporting of secretions is critical for patient assessment and should be reported in the most standardized way possible. Further research investigating the clinical relevance and treatment of accumulated secretions relies on quantitative pharyngolaryngeal secretions reporting.
The Perceived Knowledge of Fall Prevention in Nurses Working in Acute Care Hospitals in China and the United States
Authors: Wang Lin , Zhang Li , Roe Elizabeth , Decker Sally , Howard Gwen , Luth Angela , Marks Kristine , Whitman Brenda
Published: July 2021

Objective

The aim of the study was to investigate the perceived knowledge of fall prevention in nurses working in hospitals in China and the United States.

Methods

A cross-sectional survey with 17 items was used to measure perceived knowledge of fall prevention of nurses working in hospitals in China and the United States.

Results

A total of 1442 nurses at 2 hospitals completed the survey in China (90% return rate), and 260 nurses in 2 hospitals in the United States (42% return rate) for a total sample size of 1702. Six items had means less than 4, indicating less familiarity with these factors. These items included assessment of vertigo and vestibular dysfunction, vision, foot problems, balance and activity, cognitive changes, and medications. In both countries, there was a difference in 2 units worked, with those working in maternal-child having a lower perception of knowledge of fall prevention than those employed on medical-surgical units. Of the 17 items, 11 were significantly different between China and the United States, all with the United States having higher perceived knowledge.

Conclusions

For both the United States and China, the perception of knowledge of fall prevention was high. However, nurses from both countries were less familiar with the items not commonly included on fall risk tools, such as vertigo and vestibular dysfunction, vision, foot problems, balance, and cognitive changes. The findings have implications for practice and education and suggest a need to include important factors related to falls in education and intervention in both countries.
Development of 2 Short Patient-Report Questionnaires of Patient Safety in Primary Care
Authors: Mounce Luke T.A. , Salema Nde-Eshimuni , Gangannagaripalli Jaheeda , Ricci-Cabello Ignacio , Avery Anthony J. , Kadam Umesh T. , Valderas José M.
Published: July 2021

Objectives

The Patient Reported Experiences and Outcomes of Safety in Primary Care (PREOS-PC) is a valid and reliable instrument (61 items across 5 domains) of patients’ perceptions of safety. Stakeholder feedback has supported shorter versions for improving choice and facilitating uptake of routine patient-centered evaluation. We sought to develop 2 shorter versions of PREOS-PC: one including the shortest possible scales that met established measurement performance standards and a screening version including a single item per domain.

Methods

A total of 1244 patients from 45 general practices across England completed PREOS-PC questionnaires. All scale items in PREOS-PC underwent Item Response Theory analysis, applying standard criteria for the item reduction. Cognitive debriefing from 10 patient interviews allowed for the assessment of the instruments’ readability. The instruments’ psychometrics properties were reassessed in a validation sample of 1557 patients in 21 English general practices.

Results

“PREOS-PC Compact” includes 25 items and 2 open-ended questions across the 5 domains, 44% of the length of the original instrument. “PREOS-PC Screen” consists of 6 items: the best-performing single items for 2 domains, 1 item modified from original items for each of the remaining 3 domains, and 1 open-ended question. The evaluation of the instruments confirmed they were acceptable to patients and met standards for readability; construct, convergent, and divergent validity; and reliability.

Conclusions

PREOS-PC Compact meets high-performance standards while reducing patient burden for routine monitoring of patient safety in primary care. PREOS-PC Screen is a concise tool apt for incorporation into audits and to target more in-depth review as needed.
1.5 vs 3 Tesla Magnetic Resonance Imaging
Authors: Schick Fritz , Pieper Claus Christian , Kupczyk Patrick , Almansour Haidara , Keller Gabriel , Springer Fabian , Mürtz Petra , Endler Christoph , Sprinkart Alois M. , Kaufmann Sascha , Herrmann Judith , Attenberger Ulrike I.
Published: July 2021

Whole-body magnetic resonance imaging (MRI) systems with a field strength of 3 T have been offered by all leading manufacturers for approximately 2 decades and are increasingly used in clinical diagnostics despite higher costs. Technologically, MRI systems operating at 3 T have reached a high standard in recent years, as well as the 1.5-T devices that have been in use for a longer time. For modern MRI systems with 3 T, more complexity is required, especially for the magnet and the radiofrequency (RF) system (with multichannel transmission). Many clinical applications benefit greatly from the higher field strength due to the higher signal yield (eg, imaging of the brain or extremities), but there are also applications where the disadvantages of 3 T might outweigh the advantages (eg, lung imaging or examinations in the presence of implants). This review describes some technical features of modern 1.5-T and 3-T whole-body MRI systems, and reports on the experience of using both types of devices in different clinical settings, with all sections written by specialist radiologists in the respective fields.

This first part of the review includes an overview of the general physicotechnical aspects of both field strengths and elaborates the special conditions of diffusion imaging. Many relevant aspects in the application areas of musculoskeletal imaging, abdominal imaging, and prostate diagnostics are discussed.
Pseudoroseicyclus tamaricis sp. nov., isolated from seashore sediment of a Tamarix chinensis forest and emended descriptions of the genus Pseudoroseicyclus Park et al. 2016
Authors: Gai Yingbao , Yang Yongpeng , Liu Xiupian , Li Guangyu , Wang Shanshan , Lai Qiliang , Shao Zongze
Published: July 2021

An aerobic, Gram-stain-negative, bacterium, designated CLL3-39T was isolated from seashore sediment collected at a Tamarix chinensis forest in the Marine Ecology Special Reserve of Changyi, Shandong Province, PR China. Cells of strain CLL3-39T were olive-shaped and no flagellum was observed. Strain CLL3-39T grew optimally at 33 °C, pH 7.5 and salinity (sea salts) of 40 g l−1. The main fatty acids in the cell membrane of strain CLL3-39T comprised anteiso-C15 : 0 (22.3 %), iso-C15 : 0 (14.0 %), C16 : 0 (9.2 %) and summed feature 8 (contains C18 : 1
 ω7c/C18 : 1
 ω6c. 26. 7 %). The main polar lipids of CLL3-39T were phosphatidylglycerol, diphosphatidylglycerol and phosphatidylcholine. The respiratory quinone was Q10. The G+C content of the genomic DNA of strain CLL3-39T was 69.6 mol%. The average nucleotide identity between CLL3-39T and

Pseudoroseicyclus aestuarii

DB-4T was 74.7 % and the in silico DNA–DNA hybridization value was 20.1 %. Phylogenetically, strain CLL3-39T belonged to the genus

Pseudoroseicyclus

, branching with only one type strain

P. aestuarii

DB-4T with 96.3 % 16S rRNA gene similarity, followed by

Limimaricola cinnabarinus

LL-001T (95.2 %). Based on its phenotypic, phylogenetic and chemotaxonomic characteristics, we propose strain CLL3-39T (=MCCC 1A14815T
=KCTC 72665T) as a representative of a novel species in the genus

Pseudoroseicyclus

, for which the name Pseudoroseicyclus tamaricis sp. nov. is proposed.
COVID-19 Associated Hepatitis in Children (CAH-C) during the second wave of SARS-CoV-2 infections in Central India: Is it a complication or transient phenomenon
Authors: Ratho Radha Kanta , Asati Ajit Anand , Mishra Nitu , Jain Ashish , Rawat Sumit Kumar
Published: July 2021

Objective

While pediatric population has largely remained free of severe COVID-19, in some cases SARS-CoV-2 infection has been associated with complications like Multiple Inflammatory Syndrome in children (MIS-C). We mention another unique presentation subsequent to asymptomatic infection of SARS-CoV-2, a unique form of hepatitis designated by us as COVID-19 Associated Hepatitis in Children (CAH-C). The contrasting clinical presentations, temporal association and viral parameters of CAH-C cases, to the MIS-C cases are presented here.

Methods

As a retrospective and follow-up observational study we reviewed all children testing positive for SARS-CoV-2 during study period. Children presenting with “sudden onset of hepatitis, elevated transaminases, non-obstructive jaundice, lacking marked inflammatory responses and without evidence of (a) other known causes of acute hepatitis or previous underlying liver disease (b) multi-system involvement” were classified as CAH-C, are described here.

Results

Among 475 children tested positive, 47 patients presented with hepatitis, 37 patients had features of CAH-C, having symptoms of hepatitis only, with un-elevated inflammatory markers and uneventful recovery following supportive treatment. Whereas remaining 10 MIS-C hepatitis had protracted illness, multiple system involvement, required admission to critical care, and had mortality of 30%.

Conclusion

With the emergence of newer variants of concern (VOC) including the Delta variant which predominated the second wave of infections in India and has now spread to more than 142 countries with changing presentations, CAH-C might be one of them. Cases of such new entities need to be identified early and differentiated from other emerging syndromes in children during the ongoing pandemic for preventing adversities by timely intervention.

Conflicts of interest

The authors declare that they have no conflicts of interest related to the study or its findings. All authors have contributed to the conceptualization and manuscript writing of the study, the final version is approved by all the authors. We declare there are no competing interests involved among the authors.

Funding and ethics approval

Current research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors. The follow-up and analysis work was performed after obtaining due approval of human ethics committee of the institution (Ref no. IEC/BMC/80/21).
The Economic Costs of Child Maltreatment in UK
Authors: Conti Gabriella , Pizzo Elena , Morris Stephen , Melnychuk Mariya
Published: July 2021

Child maltreatment is a major public health problem with significant consequences for individual victims and for society. In this paper we quantify for the first time the economic costs of fatal and non-fatal child maltreatment in the UK in relation to several short-, medium- and long-term outcomes ranging from physical and mental health problems, to labour market outcomes and welfare use. We combine novel regression analysis of rich data from the National Child Development Study and the English Longitudinal Study of Ageing with secondary evidence to produce an incidence-based estimate of the lifetime costs of child maltreatment from a societal perspective. The discounted average lifetime incidence cost of non-fatal child maltreatment by a primary caregiver is estimated at £89,390 (95% uncertainty interval £44,896 to £145,508); the largest contributors to this are costs from social care, short-term health and long-term labour market outcomes. The discounted lifetime cost per death from child maltreatment is estimated at £940,758, comprising health care and lost productivity costs. Our estimates provide the first comprehensive benchmark to quantify the costs of child maltreatment in the UK and the benefits of interventions aimed at reducing or preventing it.