bluuebunny/crossref_metadata_2025 huggingface dataset:
PENYULUHAN PENYUSUNAN LAPORAN KEUANGAN DAN PEMERIKSAAN KAS BANK BAGI PARA SISWA YAYASAN PRIMA UNGGUL DI JAKARTA TIMUR
Authors: Nugroho Vidyarto , Amelia Wyne , Venessa Venessa
Published: November 2023

Para siswa yang bernaung dalam Yayasan Prima Unggul dididik dan diarahkan untuk menjadi pribadi mandiri dan berwawasan luas untuk dapat menjadi entrepreneur. Mereka bersekolah dengan model paket C. Wawasan yang lebih luas perlu disampaikan  agar mereka termotivasi untuk menyongsong masa depannya selepas sekolah formal. Materi yang disampaikan dalam kegiatan penyuluhan ini tentang penyusunan laporan keuangan dan pemeriksaan kas bank. Diharapkan mereka  dapat membuat perencanaan, mengatur dana dengan efektif dan efisien serta mengerti cara untuk melakukan pemeriksaan atas dana yang ada yang meliputi kas bank dan setara kas serta menyusun laporan keuangan terkait. Rencana kegiatan penyuluhan  akan dilaksanakan di lokasi Yayasan Prima Unggul di Jl. Pulomas Barat I No 37 , Jakarta Timur, DKI Jakarta pada bulan Juni 2023. Pelaksanaan akan dimulai dengan salam pembuka dilanjutkan dengan pembagian modul penyuluhan .  Penyuluhan pemeriksaan kas bank serta teknik audit terkait kas bank  ditujukan kepada siswa/siswi panti asuhan tingkat SMA/ sederajat melalui tutorial materi dan pengenalan dengan contoh-contoh .
PEMENUHAN KEWAJIBAN PERPAJAKAN MELALUI PELAPORAN SPT TAHUNAN PADA PERUSAHAAN KONTRAKTOR
Authors: Andreas Bambang Daryatno  , Said Ashadi Cahyadi  , Anivia Claudia
Published: November 2023

Sistem perpajakan yang berlaku di Indonesia yaitu self assessment system mengharuskan wajib pajak untuk melakukan perhitungan, penyetoran dan pelaporan sendiri. Pelaporan SPT Tahunan merupakan kewajiban yang harus dikerjakan oleh setiap wajib pajak. Jika kewajiban pelaporan SPT Tahunan tidak dijalankan maka wajib pajak akan kena sanksi administrasi dan tidak menutup kemungkinan sanksi pidana jika merugikan keuangan negara. Dalam pelaporan SPT Tahunan tidak cukup hanya mengisi formular 1771 atau 1770 saja, karena antara pajak satu dengan pajak lainnya saling berhubungan. Untuk itu, dalam penyusunan SPT Tahunan dibutuhkan pencocokan dan cross antar SPT yaitu SPT Masa dan SPT Tahunan. CV Tri Karya sebagai perusahaan kontraktor harus melakukan hal yang yaitu pencocokan dan cross antara total penghasilan dengan total pajak penghasilan (PPH) dan pajak pertambahan nilai (PPN). Saya selaku dosen di Jurusan Akuntansi Fakultas Ekonomi Universitas Tarumanagara diminta oleh manajemen CV Tri Karya untuk memberikan penyuluhan dan mendampingi staff perusahaan dengan judul “Pemenuhan Kewajiban Perpajakan Melalui Pelaporan Spt Tahunan Pada Perusahaan Kontraktor”
PENGGUNAAN QRIS SEBAGAI ALAT PEMBAYARAN DIGITAL UNTUK MENINGKATKAN PRODUKTIVITAS UMKM
Authors: Natsir Khairina , Bangun Nurainun , Attan Michelle Britney , Landias Joceline Sagita
Published: November 2023

ABSTRACT

E-wallet has become the primary payment method for micro, small, and medium enterprises (MSMEs) apart from cash. The convenience and ease of using e-wallets have made them a popular choice among the public. The Quick Response Code Indonesian Standard (QRIS), introduced by Bank Indonesia and the Indonesian Payment Systems Association on August 17, 2019, serves as a non-cash payment standard based on QR Codes. QRIS integrates non-cash payment systems across Indonesia, reducing the need for multiple QR Codes. Starting from January 1, 2020, services such as GoPay, OVO, and Bank Syariah Mandiri have implemented QRIS.This initiative focuses on MSMEs in RW 09, Kelapa Dua, Tangerang. Many MSMEs in this area, particularly small kiosks, have yet to adopt QRIS despite its potential to expedite transactions and record-keeping. The engagement involves conducting a training session on QRIS usage on May 6, 2023, in Kelurahan Kelapa Dua, Tangerang. A total of 25 participants are invited to learn about utilizing QRIS as a payment method and for business reporting.

ABSTRAK

E-wallet telah menjadi model pembayaran utama selain tunai bagi UMKM. Kemudahan dan kenyamanan menggunakan e-wallet menjadikannya pilihan masyarakat. QRIS, diperkenalkan oleh Bank Indonesia dan Asosiasi Sistem Pembayaran Indonesia pada 17 Agustus 2019, adalah standar pembayaran nontunai berbasis QR Code. QRIS mengintegrasikan sistem pembayaran nontunai di Indonesia, mengurangi kebutuhan akan banyak QR Code. Sejak 1 Januari 2020, layanan seperti GoPay, OVO, dan Bank Syariah Mandiri menerapkan QRIS. Kegiatan pengabdian ini berfokus pada UMKM di RW 09, Kelapa Dua, Tangerang. UMKM di daerah ini, terutama warung kecil, belum mengadopsi QRIS, meski bisa mempercepat transaksi dan pencatatan. Kegiatan pengabdian meliputi pelatihan penggunaan QRIS pada 6 Mei 2023 di Kelurahan Kelapa Dua, Tangerang. Ada 25 peserta yang diundang untuk belajar tentang penggunaan QRIS sebagai metode pembayaran dan pelaporan usaha.
GC-MS profiling and antifungal activities of Morinda citrifolia L. leaf extract against fungal pathogens of crown rot disease of banana
Authors: Haruna Aishatu
Published: November 2023

The increasing demand for organic agricultural products especially among the elite stimulated the search for safe and alternative means of crown rot disease control. Morinda citrifolia is one of the listed medicinal plants among the Polynesian countries. This study documented the phytochemical profile of M. citrifolia using GC-MS and their antifungal activities against crown rot pathogens. The key phytochemical constituents of the extract were Phytol 2-Hexadecen-1-ol, (Diterpene) (25.96%), Squalene (Triterpene) (15.13%), 1, 3-Propanediol (Polyphenol) (4.68%), Pyran-4-one 4H-, 9 (Flavonoid), and 2H-1-Benzopyran-6-ol (Vitamins) (5.14%), 2-Cyclohexan-1-one, (Phenol) (2.54%). Fungal pathogens; Lasiodiplodia theobromae, Colletotrichum musae, Colletotrichum asianum and Fussarium Longipes isolated from crown rot infected banana fruits during earlier studies were used in this experiment. The poisoned food technique method was adopted in evaluating the inhibitory effect of the leaf extract against the fungal isolates. Results indicated significantly high fungal growth inhibition (P< 0.05) in concentration dependent manner on amended PDA media. 100% pathogen radial growth inhibition in all isolates was recorded at 100 mg/mL concentration. Therefore, findings of this study suggest application of leaf extract of M. citrifolia is a potential safe and alternative control of banana crown rot.
Contextualising Middle English Liturgical Commentaries /
Authors:   University of Glasgow (UK), Smith Jeremy J.
Published: November 2023

Important discussions of Middle English miscellanies, with special reference to works of religious instruction, include, for instance, work by Margaret Connolly (2003, 2011) and Ralph Hanna (e.g., 1996, 2007, 2010). But much detailed work remains to be done, from various disciplinary perspectives, to respond to the challenge set inter alia by Thorlac Turville-Petre forty years ago, viz., to set such works “much more securely and illuminatingly within [their] local context” (1983, 141). In this paper, part of an ongoing programme of research into the ‘cultural mapping’ of Middle English writings on the liturgy (see e.g., Jasper and Smith 2019, 2023; Smith 2021), a range of verse and prose texts are placed in their codicological contexts. It will be demonstrated how the forms of these texts correlate closely with the socio-cultural functions of the manuscripts in which they survive.
General Patterns of Punctuation in the Paston Letters
Authors:   University of Málaga (Spain), Calle-Martín Javier , Thaisen Jacob ,   University of Oslo (Norway)
Published: November 2023

The late Middle Ages saw a proliferation in the number of marks of punctuation as a result of the development of cursive hands and scripts. While the punctus had been the principal mark used in the Anglo-Saxon period, other marks like the paragraphus, the virgule, the perioslash and the hyphen were progressively incorporated into the repertoire of punctuation. The inventory of marks and their functions settled over time, but it was not until the seventeenth century when we find the early symptoms of normalization (Calle-Martín forthcoming). Even though some recent studies have focused on the analysis of the punctuation system deployed in different text types–literary, scientific and legal material in particular–, letters have, however, not been the focus of these studies. This paper therefore analyses what marks are present in the Paston Letters and what their functions are. Particular attention is paid to the punctus and the virgule as marks with overlapping uses in the period.
Rereading Doris Lessing’s Short Story “Wine” Through the Lenses of Space, History and Traumatic Memories
Authors:   University of Málaga (Spain, Berio María Eugenia
Published: November 2023

Doris Lessing has been called a writer “ahead of her time” (Drabble 2008; Maslen 1994) due to the kind of issues she explored in her narrative. The topic of war and its everlasting effects stand as an invisible thread that runs through her entire oeuvre to present the reader with the devastation brought about by the world wars not only in the physicality of cities and towns but also in the bodies and minds of the survivors. The historical events that marked the twentieth century broke people’s morale and the memories of the horrors witnessed flooded back poisoning their lives. The present article draws on the interconnection between space, history, and trauma in Doris Lessing’s short story “Wine” (1957). By exploring the enduring relationship between these three variables she creates her Poetics of Space in which she not only crosses spatiotemporal boundaries but also public and private spheres.
IMMUNOSUPPRESSION AS AN ADVERSE FACTOR OF DEATH IN BURN INJURY
Authors:   3rd Military Hospital of the National Guard of the Russian Federation, Saint Petersburg, Selivanov P.A.
Published: November 2023

The influence of T-regulatory (Treg.) lymphocytes was analyzed in burn injury (BI). The values of this indicator to BI mortality have been determined. The threshold values of the relative concentration of Treg. have been clarified in the post-traumatic period of BI in order to predict the probability of a fatal outcome.
DIFFERENTIAL INFLAMMATION TEST SYSTEM DEVELOPMENT
Authors:   Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Silvanovich E.K. , Polyakova A.A. , Shalik I.K. , Kurchenko O.M. , Malshakova B.A. ,   Novosibirsk State University
Published: November 2023

This work is aimed at creating a test system based on aptamers that can semiquantitatively determine the concentrations in saliva of such inflammatory markers as C-reactive protein and Procalcitonin.
PLATFORM FOR THE DEVELOPMENT OF SAFE SUBUNIT VACCINES
Authors:   Razvitie Biotekhnologii, JSC, Moscow, Sukhova M.M. , Krasilnikov I.V. , Isaev A.A. , Vakhrusheva A.V. , Ivanov A.V. , Tsymbarevich I.V. ,   Artgen Biotech, PJSC, Moscow
Published: November 2023

This paper presents vaccines developed using corpuscular bitulin as an adjuvant. The vaccines aim to protect against the influenza virus, SARS-CoV-2, and their combination.
ENTOMOPATHOGENIC ACTIVITY OF GRANULOVIRUS STRAINS AGAINST CYDIA POMONELLA
Authors:   Federal Research Center of Biological Plant Protection, Krasnodar, Tomashevich N.S. , Tsygichko A.A.
Published: November 2023

The paper presents the results of the four granulosa virus of the apple moth strains entomopathogenic activity from the bioresource collection of the Federal Research Center of Biological Plant Protection «State Collection of Entomoacariphages and Microorganisms» against C. pomonella in vitro. The most effective strains of the apple moth granulosa virus (BZR GV 11 and BZR GV L-3) were revealed. The level of entomopathogenic activity of them was 80,6 % on the tenth day of the experiment.
RESISTANCE OF A CONSORTIUM OF LACTIC ACID BACTERIA TO OPPORTUNISTIC PATHOGENS
Authors:   Kemerovo State University, Frolova A.S. , Milentyeva I.S.
Published: November 2023

We studied a consortium based on acidophilic (non-viscous and viscous Lactobacillus acidophilus) and curd (Streptococcus thermophilus and Lactococcus lactis) starter cultures in a ratio of 1 : 4. The consortium is resistant to the following opportunistic pathogens: Escherichia coli, Candida lipolit, Staphylococcus albus and Aspergillus niger.
ENDOPHYTIC BACTERIA AS PRODUCERS OF INDOLYL-3-ACETIC ACID
Authors:   Kemerovo State University, Frolova A.S. , Kolpakova D.E. , Khoroshkina N.N. , Bezyazykova M.N. , Karchin K.V.
Published: November 2023

From the seeds of cereal crops (Avena sativa L., Triticum L., Secale cereale L. и Hordeum L.), 6 endophytic bacteria were isolated that can survive on poor soils that are resistant to salinity, herbicides and insecticides. The strains synthesize indolyl-3-acetic acid (IAA), concentration from 4,49 to 9,00 mg/ml. The isolated endophytes are promising for compiling a consortium of microorganisms capable of stimulating plant growth.
DETERMINATION OF CHICKEN MEAT SPOILAGE USING A SENSOR BASED ON A MAGNETITE NANOPARTICLES
Authors:   SCAMT Institute, ITMO University, Saint Petersburg, Khasanov D.G. , Nazarova E.A.
Published: November 2023

A colorimetric sensor for hydrogen sulfide was developed to monitor the freshness of chicken meat. The operation principle of the indicator is due to the ability of magnetite nanoparticles to irreversibly bind to H2 S, released during spoilage of chicken breast, and to influence the color intensity of the chromogen. This strategy has provided a reliable, cost-effective, and easy-to-use platform for meat quality monitoring.
OPTIMIZATION OF CONDITIONS FOR IN VITRO TRANSCRIPTION OF MRNA CATALYSED BY RECOMBINANT T7 RNA POLYMERASE AND POLY(A)-POLYMERASE
Authors:   Peter the Great Saint Petersburg Polytechnic University, Yurchenko A.V. , Zimmerman E.L. , Dobrovolskaya O.A. , Vysochinskaya V.V. , Elpaeva E.A. ,   Smorodintsev Research Institute of Influenza, Saint Petersburg
Published: November 2023

The in vitro transcription reaction (IVT) is an important step in the production of synthetic mRNAs. Optimizing the reaction conditions of the IVT and using its own reactants will minimize the reaction time and costs at maximum yield. We synthesized mRNAs using original T7-Pol and PAP enzymes, performed translation, transfection, and fluorescence intensity analyses of the obtained samples versus control commercial mRNAs.
Treiber der Digitalisierung
Authors: Bensberg Frank , Buscher Gandalf
Published: November 2023

Transformationale Informationstechnologien gelten als Treiber der Digitalisierung, die den Wandel von Unternehmensprozessen, Wertschöpfungsketten und Märkten forcieren. Zwar findet in der Wirtschaftsinformatik eine intensive Auseinandersetzung mit diesen Informationstechnologien statt, allerdings werden deren arbeitsmarktbezogenen Implikationen meist vernachlässigt. Dieser Beitrag greift diese Fragestellung auf, indem Stellenanzeigen der DAX30-Unternehmen in Bezug auf transformationale Informationstechnologien untersucht werden. Es wird gezeigt, welche Bedeutung einzelne Informationstechnologien haben, und welche Berufsbilder sowie Kompetenzen mit diesen verknüpft sind.
Research Agenda for Mobile Context Sensitive Business Processes
Authors: Dörndorfer Julian , Seel Christian
Published: November 2023

Mobile devices like smartphones and tablets are ubiquitous and have affected many daily work activities such as maintaining contacts via a mobile CRM. Furthermore, mobile devices provide many sensor data. They measure physical quantities like location or acceleration. In addition, the connection to wireless networks made it feasible to query data in real time, like customer history or the next calendar appointment. These sensor information and data could be used to enhance business processes with context. The context information could be utilized to adapt business process and mobile applications automatically to the current situation. Therefore, this paper aims at evaluating existing approaches for mobile business process and business process adaption in a literature review. Furthermore, it shows how existing approaches cover the business process lifecycle and reveals gaps for a further research agenda.
Zirconia-supported Pt, Pd, Rh, Ru and Ni catalysts in the hydrotreatment of fatty amides and amines
Authors: Verkama Emma , Albersberger Sylvia , Meinander Kristoffer , Tiitta Marja , Karinen Reetta , Puurunen Riikka L.
Published: November 2023

Active catalysts for simultaneous hydrodeoxygenation (HDO) and hydrodenitrogenation (HDN) enable the production of fuels from renewable feedstocks. In this work, zirconia-supported nickel, ruthenium, rhodium, palladium and platinum catalysts were evaluated in the HDO and HDN of n-hexadecanamide (C16 amide). The HDN of 1-hexadecylamine (C16 amine) was studied separately to assess the HDN activity and preference between C–C and C–N bond cleavage routes without the interference of HDO. The differences in the catalytic activity were mainly attributed to the metal identity. Pt/ZrO2 and Ru/ZrO2 exhibited the highest activity towards the conversion of both model compounds. The C16 amide was converted more efficiently than the C16 amine over the studied catalysts, and a high HDO activity did not translate to a high activity in HDN, which was particularly evident in the case of Rh/ZrO2. The active metal strongly influenced the preferred reaction routes, as observed from differences in the yields of C15 and C16 n-paraffins and C32 condensation products. Ni/ZrO2 and Pd/ZrO2 exhibited the lowest activity and paraffin selectivity in the hydrotreatment of both model compounds. Ru/ZrO2 and Rh/ZrO2 favored the formation of n-pentadecane from both the C16 amine and C16 amide, whereas Pt/ZrO2 produced n-hexadecane and high intermediate yields of the C32 condensation products.
Endergonic synthesis driven by chemical fuelling
Authors: Olivieri Enzo , Gallagher James M. , Betts Alexander , Mrad Toufic W. , Leigh David A.
Published: November 2023

Spontaneous chemical reactions proceed energetically downhill to either a local or global minimum, limiting possible transformations to those that are exergonic. Endergonic reactions do not proceed spontaneously and require an input of energy. Light has been used to drive a number of deracemisations and thermodynamically unfavourable bond-forming reactions, but is restricted to substrates that can absorb, directly or indirectly, energy provided by photons. In contrast, anabolism involves energetically uphill transformations powered by chemical fuels. Here we report on the transduction of energy from an artificial chemical fuel to drive a thermodynamically unfavourable Diels–Alder reaction. Carboxylic acid catalysed carbodiimide-to-urea formation is chemically orthogonal to the reaction of the diene and dienophile, but transiently brings the functional groups into close proximity, causing the otherwise prohibited cycloaddition to proceed in modest (12%) yield and with high levels of regio- (>99%) and stereoselectivity (92:8 exo:endo). At the chemically fuelled steady state, kinetic asymmetry in the fuelling cycle ratchets the Diels–Alder reaction away from the equilibrium distribution of the Diels–Alder:retro-Diels–Alder products. The driving of the endergonic reaction away from equilibrium occurs through a ratchet mechanism, reminiscent of how molecular machines directionally bias motion. Ratcheting synthesis has the potential to expand the synthetic chemistry toolbox, offering new paradigms in reactivity, complexity and control.
Process Intensification of the Continuous Synthesis of Bio-derived Monomers for Sustainable Coatings using a Taylor Vortex Flow Reactor
Authors: Edwards Matthew D. , Pratley Matthew T. , Gordon Charles M. , Teixeira Rodolfo I. , Ali Hamza , Mahmood Irfhan , Lester Reece , Love Ashley , Hermens Johannes G. H. , Freese Thomas , Feringa Ben L. , Poliakoff Martyn , George Michael W.
Published: November 2023

We describe the optimization and scale-up of two consecutive reaction steps in the synthesis of bio-derived alkoxybutenolide monomers that have been reported as potential replacements for acrylate-based coatings (Sci. Adv., 2020, 6, eabe0026). These monomers are synthesized by (i) oxidation of furfural with photo-generated singlet oxygen followed by (ii) thermal condensation of the desired 5-hydroxyfuranone intermediate product with an alcohol, a step which until now has involved a lengthy batch reaction. The two steps have been successfully telescoped into a single kilogram-scale process without any need to isolate the 5-hydroxyfuranone between the steps. Our process development involved FTIR reaction monitoring, FTIR data analysis via 2D-visualization and two different photo-reactors (i) a semi-continuous photo-reactor based on a modified rotary evaporator where FTIR and 2D-correlation spectroscopy (2D-COS) revealed the loss of the methyl formate co-product and (ii) our fully continuous Taylor Vortex photo-reactor which enhanced the mass transfer and permitted the use of near-stoichiometric equivalents of O2. The use of inline FTIR monitoring and modelling greatly accelerated process optimization in the Vortex reactor. This led to scale up of the photo-oxidation with an 85% yield and a projected productivity of 1.3 kg day-1, with a space time yield of 0.06 mol day-1 mL-1. Higher productivities could be achieved whilst sacrificing yield; e.g. 5 kg day-1 at 65% yield. The second step, the thermal condensation of 5-hydroxyfuranone, was transformed from a 20 h batch reflux reaction to a < 1 minute thermal flow reaction in a reactor only 3 mL in volume operating at 200 oC with projected productivities of >700 g day-1. Proof of concept for telescoping the two steps was established with an overall two-step yield of 67%, producing a process with projected productivity of 1.1 kg day-1 of the methoxybutenolide monomer without any purification of the 5-hydroxyfuranone intermediate.
Design and synthesis of 4-amino-2’,4’-dihydroxyindanone derivatives as potent inhibitors of tyrosinase and melanin biosynthesis in human melanoma cells
Authors: Lazinski Leticia M. , Beaumet Morane , Roulier Brayan , Gay Rémy , Royal Guy , Maresca Marc , Haudecoeur Romain
Published: November 2023

Melanogenesis inhibition constitutes a privileged therapeutic solution to treat skin hyperpigmentation, a major dermatological concern associated with the overproduction of melanin by human tyrosinase (hsTYR). Despite the existence of many well-known TYR (tyrosinase) inhibitors commercialized in skin formulations, their hsTYR-inhibition efficacy remains poor since most of them were investigated over mushroom tyrosinase (abTYR), a model with low homology relative to hsTYR. Considering the need for new potent hsTYR inhibitors, we designed and synthesized a series of indanones starting from 4-hydroxy compound 1a, one of the two most active derivatives reported to date against the human enzyme, together with marketed thiamidol. We observed that analogues featuring 4-amino and 4-amido-2’,4’-dihydroxyindanone motifs showed two- to ten-fold increase in activity over human melanoma MNT-1 cell lysates, and a ten-fold improvement in a 4-days whole-cell experiment, compared to parent analogue 1a. Molecular docking investigation was performed for the most promising 4-amido derivatives and suggested a plausible interaction pattern with the second coordination sphere of hsTYR, notably through hydrogen bonding with Glu203, confirming their impact in the binding mode with hsTYR active site.
Chemistry of Cyclo-[2n]-Carbon: A Many-Particle Quantum Mechanics Investigation
Authors: Chen Xi , Yan Xueyuan , Liu Zihan , Yuan Tao , Bu Caijie , Shang Yunlong , Xiao Han , Wu Yong , Wei Haiyan , Xu Jiawei
Published: November 2023

Direct observations of cyclo-[2n]-carbon molecules (C10, C14, C16 and C18) experimentally prepared by atom manipulation technique raised immense attraction in the general chemistry society. The cyclic π-conjugated systems, namely in-plane and out-plane, construct dual aromaticity for odd n while dual anti-aromaticity for even n. In this work, we performed electronic structure investigation into cyclo-[2n]-carbon with n = 3 ~ 9 by comparing results obtained by density functional theory (DFT) and density matrix renormalization group (DMRG) method. By using Huckel molecular orbital (HMO) theory and the particle in a ring model, the electronic feature of such innovative carbon allotrope was clearly and chemically presented. Comparison showed that DFT results are considered to be incorrect for C6, which has a unique bonding structure among all cyclo-[2n]-carbon. The bond length alternating (BLA) phenomenon results from difference in electron correlation intensity and spatial distribution observed in pairs of bonding and anti-bonding orbitals. Therefore, results suggested that the dual anti-aromaticity in cyclo-[2n]-carbon with even n should be attributed to electron correlation effect, instead of decreased geometric symmetry, which actually exists in all cyclo-[2n]-carbon molecules and does not point out the essence.
Binding of Phenothiazine Drugs to Heptakis-Methylated β- Cyclodextrin Derivatives: Thermodynamics and Structure
Authors: Andrade Brenda , Chen Ashley , Gilson Michael K.
Published: November 2023

Model systems are widely used in biology and chemistry to gain insight into more complex systems. In the field of computational chemistry, researchers use host-guest systems, relatively simple exemplars of noncovalent binding, to train and test the computational methods used in drug discovery. Indeed, host-guest systems have been developed to support the community-wide blinded SAMPL prediction challenges for over a decade. While seeking new host-guest systems for the recent SAMPL9 binding prediction challenge, which is the focus of the present PCCP Themed Collection, we identified phenothiazine as a privileged scaffold for guests of β cyclodextrin (βCD) and its derivatives. Building on this observation, we used calorimetry and NMR spectroscopy to characterize the noncovalent association of native βCD and three methylated derivatives of βCD with five phenothiazine drugs. The strongest association observed, that of thioridazine and one of the methyl derivatives, exceeds the well-known high affinity of rimantidine with βCD. Intriguingly, however, methylation of βCD at the 3 position abolished detectible binding for all of the drugs studied. The dataset has a clear pattern of entropy-enthalpy compensation. The NMR data show that all of the drugs position at least one aromatic proton at the secondary face of the CD, and most also show evidence of deep penetration of the binding site. The results of this study were used in the SAMPL9 blinded binding affinity-prediction challenge, which are detailed in accompanying papers of the present Themed Collection. These data also open the phenothiazines and, potentially, chemically similar drugs, such as the tricyclic antidepressants, as relatively potent binders of βCD, setting the stage for future SAMPL challenge datasets and for possible applications as drug reversal agents.
Nominations of Russian aggression against Ukraine in English-language media: A cognitive-pragmatic study
Authors: Shevchenko Iryna , Morozova Iryna , Shevchenko Vadym
Published: November 2023

During 2014–2022, the English-language media used several most common nominations for Russia's armed aggression against Ukraine, from CRISIS and SPECIAL OPERATION to WAR, and the choice of the nomination testifies to the political position of the media and changes as events develop. This present study proves that different structures of these concepts determine their different place in the English linguistic world construal and, accordingly, their perception by native speakers. The hypothesis of the work is the thesis that ARMED AGGRESSION is a gestalt multi-appealed concept, different nominations of which – war, operation, crisis – activate different domains in the Eng lish linguistic world construal and in this way manipulate consciousness by changing the concept perception. In order to establish the place of individual concepts in the English linguistic world construal, we conduct a semantic analysis of lexemes representing these concepts, determine their structure and profiling directions. Building on the comprehensive cognitive-pragmatic methodology, the authors establish the semantic volume of lexemes-nominations of these concepts. Their comparative analysis proves that the concept of WAR is the most accurate equivalent of a state of armed aggression, while other concepts distort native speakers’ perceptions of the state of affairs and serve as a means of manipulation, distracting from the aggressor’s war crimes, defenders’ victories and the tragedy of the civilian population suffering from aggression. We claim that there are four main aggressor’s discourse tactics of manipulation: deny, distract, distort, dismay. Our empirical data were obtained from explanatory and etymological dictionaries of the English language and from leading US print media.
Features of foreign competency formation when preparing for international language exams at the School of Foreign Languages
Authors: Zeniakin Oleksii , Pasynok Valentyna , Nemchonok Semen
Published: November 2023

The article is devoted to the study of the structure of international language exams on example of the PEIC (PTE) test by “Pearson plc” which can be taken at the International Language Certification Centre of V. N. Karazin Kharkiv National University. Special attention is paid to the necessity to make appropriate changes to the current Educational Curriculum of English as the major for students of the pedagogical (philological) and translation studies departments. The methodological basis of the study includes general scientific methods, special attention is paid to the case method, because the authors have experience in organizing, compiling and training for international language exams. This paper aims at presenting a range of tasks of PEIC (PTE) and guidelines for adjusting the current Educational Curriculum as well as the process of potential implementation into the framework of the Educational Curriculum exercises that can condition success in passing international exams. The object matters of the research are peculiar tasks of the international language exam PEIC (PTE) as well as exercises from the textbooks of the School of Foreign Languages which make up the body of empirical material comprising 104 units. The subject matter of analysis was the character of these exercises. The topicality of the work is accounted for by lack of comprehensive scientific research in this area in Ukraine as it is intensified by the significant interest of senior students in obtaining an international certificate. The study found that the PEIC (PTE) exam has two main structural elements: written and oral ones. Thus, their integration into the current Educational Curriculum is proposed in this study by offering some adjustments to the aspects of "Oral Practice" and "Analytical Reading" while teaching at the School.
Stylistic features of the Chinese-language artistic and scientific Internet discourse
Authors: Pikhtovnikova Lydia , Bets Yelyzaveta
Published: November 2023

The article examines stylistic features of Chinese-language fiction and scientific Internet discourse. It considers the concept of "internet discourse", as well as the concepts of "fiction discourse" and "scientific discourse", gives an explanation of certain lexical and grammatical features of the Chinese language. Their manifestation in the considered types of Internet discourse is analyzed. It is noted that the vocabulary of fiction Internet discourse tends to simplification, abbreviations, the use of idioms and catchphrases for greater concentration of information. The authors also use onomatopoeia to imitate the sounds of the surrounding reality by phonetic means of speech. It is shown on examples how, in contrast to popular science texts, the authors of fiction works use reduplication much more often, thereby creating a language more favorable for communication. It is explained why there are quite a lot of slang words in the artistic works of online discourses, which decorate and distinguish the work of the authors. This phenomenon reflects the existence of many dialects and changes in the language, the use of slang words depends on the origin of the author, as well as the emotional color that the author wants to reproduce. The use of linguistic stylistic means is highlighted on the examples of popular scientific and fiction texts. The lexical and grammatical means of expressiveness of the Chinese language of the texts published on the Internet are analyzed. It is indicated that an important feature of Internet works is the use of emoticons and various signs in the texts (smiley of tears, emoticon of shyness, etc.). The functioning of linguistic and stylistic means in the scientific and artistic type of Internet discourse is shown in the comparison. At the grammatical level, fiction and popular science texts are almost the same, there is the use of exclamation points for greater unity between the author and the reader, but in popular science texts they are more restrained and occur only when the author quotes his clients. There is a significant difference between popular science text and fiction. It is noted that the authors of the fiction discourse try to have more contact with the readers, conditionally involve them in the creation of the finale of the fiction work.
Verbal and non-verbal aspects of the love strategy implementation in modern English discourse
Authors: Soloshchuk Liudmyla , Tieniaieva Anastasiia
Published: November 2023

The article focuses on the study of the functioning of verbal and non-verbal components of communication in the English-language marital discourse in communicative situations “first acquaintance”, “flirting”, “declaration of love” and “marriage proposal”. The aspects of communication of the subjects differ depending on the types of lovers that were identified on the basis of the illustrative material studied: these are representatives of romantic, pragmatic and manic types of lovers as well as subjects of ludus love. It has been established that romantic lovers are characterized by high expressiveness in the process of communication both at the verbal and non-verbal levels; the pragmatic type of lovers is characterized by a lack of creativity in expressing feelings of love, consistency of speech and formality in communication; a manic lover is prone to manipulation and emotional blackmail; the subjects of ludus love in the process of flirting resort to banter, jokes, puns, the use of nicknames, ironic expressions, as well as non-verbal components of communication to reduce the social distance in the relationship with the object of love. The article takes into account the influence of the age component on the communication of lovers in pre-matrimonial and matrimonial types of discourse as a result of comparing the characteristics of three age groups of lovers, namely, teenagers aged 13 to 19, adults aged 20 to 40 and lovers aged 40+. Common and distinctive characteristics of the use of verbal and non-verbal components of communication for the specified types of speakers have been clarified.
Undergraduate students' perception of the level of development of information literacy skills
Authors:   Transilvania University of Brașov, Popa Daniela , Repanovici Angela ,   Transilvania University of Brașov
Published: November 2023

Digital natives are often perceived as experts in managing digital technology, but recent studies show that they do not have a very high level of developing information literacy skills. This research aimed to investigate the relationships between students' level of development of information literacy skills and the teacher's level of expression of pedagogical skills. A correlational research design was used. The research method was questionnaire survey. The results show that there are links between how students perceive pedagogical competences in action and the level of assimilation of information and information literacy skills.
Scientometric analysis of 3D printing in libraries, and implications for copyright
Authors:   Transilvania University of Brașov, Barsan Mihai , Landoy Ane ,   Norwegian Government, The Directorate for Higher Education and Skills, Barsan Ionela Maria , Repanovici Angela
Published: November 2023

3D printing is a process whereby users can create a three-dimensional solid object of any shape by operating a 3D printer using a digital design, thereby creating their own designs or replicate and electronically customize scanned objects. The technology has existed for several decades; however, it was not until around 1990 it really gained momentum (Van Wiele, 2019). In this paper the authors investigated research on 3D printing in libraries and copyright through a scientometric analysis, by searching in Web of Science for libraries, 3D printing and copyright. The data was mapped in WoS-viewer, to show the most important authors, the most cited documents, and the most cited sources. 107 results from WoS Core Collection for “3D printing” AND copyright was found. Also, the authors researched library websites in Norway for guidelines and rules concerning copyright and 3D printing. Norwegian copyright law does not mention 3D printing as such, so how are academic and public libraries teaching or mentoring copyright issues to patrons and students?
Information needs and practices in teaching and using industrial property for nonlawyers in Slovenia
Authors:   University of Ljubljana, Tjaša Jug , Polona Vilar ,   University of Ljubljana, Švab Katarina ,   University of Ljubljana
Published: November 2023

"Introduction. The paper presents some findings of the Erasmus+ project IPEDU, which aims to include intellectual property education, more specifically industrial property, in the curriculum of technical universities, through training the teaching, support staff and librarians. We present selected results of the first two project stages for Slovenia, which is one of the project partners. Methods. Initial stages of the project assess the current level of inclusion of industrial property topics into higher education curricula and labour market needs. Samples include Slovenian technical sciences faculties, and employers of technical profiles with needs for industrial property knowledge. Online surveys are used for data collection. Results. General, not positive, alignment was found in terms of expected competencies: Companies do not place high priorities on industrial property competencies of their non-law employees. Furthermore, many higher education institutions do not include these topics in their teaching. Industrial property teaching is needed, but not done, which implies the need for educators-employers dialogue. A relatively traditional image of libraries emerges, as they are usually not involved in teaching. This provides an excellent opportunity for libraries to evolve and become more proactive. Conclusions. Our findings offer a valuable contribution to the planning of a systematic and holistic intellectual property curriculum for technical studies within the European Union."
Oral English Autonomous Learning Ability of English Majors Under the Background of the Internet and Its Improvement
Authors: Zhu Xiaohong
Published: November 2023

The Internet is an important means of communication for contemporary college students, especially those majoring in English, to acquire knowledge about information and improve their oral proficiency. However, research on the relevant oral English autonomous learning ability of English majors shows that the overall learning situation is not satisfying. Based on the development of the concept of autonomous learning, this article explores the current situation and existing problems in oral English autonomous learning of English majors under the context of the Internet, and proposes corresponding autonomous learning strategies for improving their oral English skill.
Countermeasures of “Post-Course Competition Certificate” Mode to Promote Innovation and Reform of BIM Course in Vocational Colleges
Authors: Yang Yuqing , Zhao Shan
Published: November 2023

The model of “post-course competition certificate” can be the basic model of Building Information Modeling (BIM) course teaching in vocational colleges in the new era, and many vocational colleges have also made attempts to construct and apply this model in BIM courses and other professional courses. Based on the application of methods such as literature review and observation, it can be found that it is highly feasible in theory and practice to promote the innovation and reform of BIM curriculum based on this model. However, there are more influencing factors at the practical level, which can easily lead to some problems. In this paper, we will analyze the corresponding problems and put forward a more effective reform strategy of BIM course education innovation in combination with reality.
A Study of the English Translation of Positive Emotions from the Perspective of Conceptual Metaphor
Authors: Wang Xiaodong , Wei Xueling
Published: November 2023

Emotion is a complex and abstract experience shared by human beings, but it is often expressed in the form of conceptual metaphor which is pervasive in the concrete language. Drawing upon the theory of conceptual metaphor and emotion metaphors, this paper aims to study the translation of positive emotions in David Hawkes’ version of The Story of the Stone and the related daily expressions as the corpus. According to the theories, this paper categorizes the positive emotions metaphors into body metaphors, sensory metaphors, entity metaphors, and orientational metaphors to discuss the process of English translation and the metaphorical mechanism, analyzes the similarities and differences between Chinese and English expressions of positive emotions and their cultural, physiological, and psychological motives, and lastly attempts to summarize the translation strategies of emotional expressions. The analysis of metaphorical mechanisms reveals that the common physiological and psychological experiences of human beings and cultural exchanges give rise to similarities, while the unique cultural environments, antecedents, and historical development of each nation give rise to their distinctiveness. This paper concludes that translators need to make full use of their subjectivity, understand the surface and underlying meaning of the text, and establish a high level of mental compatibility between themselves, the readers, and the author.
Effectiveness of Participatory Teaching Methods in the Standardized Training of Respiratory Medicine Residents
Authors: Wang Yanbing , Feng Jieru
Published: November 2023

Objective: To explore and analyze the application effect of participatory teaching method in the standardized training of respiratory medicine residents. Methods: The study period was from May 2022 to May 2023. 20 doctors in the standardized training of respiratory medicine residency in our hospital were taken as research subjects and grouped into the participatory group (n = 10) and the routine group (n = 10) by using the random number lottery method. The participatory group practised participatory teaching methods, and the routine group practised routine teaching methods. The results of discharge assessment, teaching evaluation, and mini-Clinical Evaluation Exercise (mini-CEX) assessment were compared between the groups. Results: The theoretical assessment, operational assessment, and total scores of the participatory group were significantly higher than those of the routine group, and the difference was statistically significant (P < 0.05). The teaching evaluation of independent learning, theoretical mastery, teamwork, clinical thinking, communication, and learning interest of the participatory group was significantly higher than that of the routine group, and the difference was statistically significant (P < 0.05). The mini-CEX assessments of history inquiry, organizational effectiveness, professionalism, physical examination, clinical diagnosis, communication skills, and overall clinical competence of the participatory group were significantly better than those of the routine group, and the difference was statistically significant (P < 0.05). The teaching satisfaction of the participatory group was significantly higher than that of the routine group, the difference was statistically significant (P < 0.05). Conclusion: Participatory teaching methods can improve the overall level of doctors in the respiratory medicine residency standardized training, and the teaching satisfaction is improved.
Первый пример октаэдрического теллуридного кластерного комплекса рения с органическим N-донорным лигандом
Authors: Новикова Е.Д. , Коновалов Д.И. , Иванов А.А. , Куратьева Н.В. , Берёзин А.С. , Шестопалов М.А.
Published: November 2023

Катионный кластерный комплекс [{Re6Te8}(imzH)6]2+ получен взаимодействием [{Re6Te8}(TeI2)6]I2·[{Re6Te8}(TeI2)4(TeI3)2]·I2 с имидазолом (imzH) в запаянной стеклянной ампуле при 200 °С в течение 48 часов. Состав полученного соединения был подтвержден с помощью 1Н ЯМР спектроскопии, а также масс-спектрометрии высокого разрешения. Путем медленной диффузии паров диэтилового эфира в раствор комплекса в ДМФА удалось получить монокристаллы пригодные для рентгеноструктурного анализа, согласно данным которого образуется [{Re6Te8}(imzH)6]I2·2/3DMF. Соединение кристаллизуется в моноклинной сингонии, пространственная группа Р21/c, с параметрами элементарной ячейки a = 18.0379(4), b = 17.9945(5), c = 33.1318(7) Å, β = 115.1829(10)⁰, V = 9732.0(4), Z = 6. Более того, было показано, что соединение проявляет характерную для октаэдрических кластерных комплексов рения люминесценцию в твердом теле, с максимумом эмиссии 730 нм.
Influence of plant growth regulators on the main morphological parameters of Paeonia
Authors: Reut Antonina Anatolievna
Published: November 2023

The article reflects the results of studying the effectiveness of the action of the specialized preparations «Lignohumate» and «Trener» on the growth, development and decorative qualities of some representatives of the Paeonia L. genus complex in the conditions of the forest-steppe zone of the Bashkir Cis-Ural. For the first time in the conditions of the Southern Ural, the influence of new growth stimulants on the decorativeness of some varieties of Paeonia lactiflora from the collection of the SUBGI UFRC RAS was studied. It is shown that under the influence of the studied preparations there was an increase in the number of shoots and flowers on one peduncle, as well as a change in the diameter and height of the flower. It was noted that the use of growth regulators significantly affected the following decorative features: the size of the flower, the abundance of flowering and the number of buds on the peduncle. Among the economic and biological parameters, a large difference between the control and the experiment was noted for the traits: productivity and duration of flowering, reproductive ability and resistance to diseases and pests. Thus, the studied plant growth regulators can be recommended for use in floriculture, as they increase the decorative effect of cultivars.