bluuebunny/crossref_metadata_2025 huggingface dataset:
Including filter-feeding gelatinous macrozooplankton in a global marine biogeochemical model: model–data comparison and impact on the ocean carbon cycle
Authors: Clerc Corentin , Bopp Laurent , Benedetti Fabio , Vogt Meike , Aumont Olivier
Published: February 2023

Abstract. Filter-feeding gelatinous macrozooplankton (FFGM), namely salps, pyrosomes and doliolids, are increasingly recognized as an essential component of the marine ecosystem. Unlike crustacean zooplankton (e.g., copepods) that feed on prey that are an order of magnitude smaller, filter feeding allows FFGM to have access to a wider range of organisms, with predator-over-prey size ratios as high as 105:1. In addition, most FFGM produce carcasses and/or fecal pellets that sink 10 times faster than those of copepods. This implies a rapid and efficient export of organic matter to depth. Even if these organisms represent < 5 % of the overall planktonic biomass, their associated organic matter flux could be substantial. Here we present a first estimate of the influence of FFGM on the export of particulate organic matter to the deep ocean based on the marine biogeochemical model NEMO-PISCES (Nucleus for European Modelling of the Ocean, Pelagic Interaction Scheme for Carbon and Ecosystem Studies). In this new version of PISCES, two processes characterize FFGM: the preference for small organisms due to filter feeding and the rapid sinking of carcasses and fecal pellets. To evaluate our simulated FFGM distribution, we compiled FFGM abundance observations into a monthly biomass climatology using a taxon-specific biomass–abundance conversion. Model–observation comparison supports the model's ability to quantify the global and large-scale patterns of FFGM biomass distribution but reveals an urgent need to better understand the factors triggering the boom-and-bust FFGM dynamics before we can reproduce the observed spatio-temporal variability of FFGM. FFGM substantially contribute to carbon export at depth (0.4 Pg C yr−1 at 1000 m), particularly in low-productivity regions (up to 40 % of organic carbon export at 1000 m), where they dominate macrozooplankton biomass by a factor of 2. The FFGM-induced export increases in importance with depth, with a simulated transfer efficiency close to 1.
Automated classification of seismic signals recorded on the Åknes rock slope, Western Norway, using a convolutional neural network
Authors: Langet Nadège , Silverberg Fred Marcus John
Published: February 2023

Abstract. A convolutional neural network (CNN) was implemented to automatically classify 15 years of seismic signals recorded by an eight-geophone network installed around the back scarp of the Åknes rock slope in Norway. Eight event classes could be identified and are adapted from the typology proposed by Provost et al. (2018), of which five could be directly related to movements on the slope. Almost 60 000 events were classified automatically based on their spectrogram images. The performance of the classifier is estimated to be near 80 %. The statistical analysis of the results shows a strong seasonality of the microseismic activity at Åknes with an annual increase in springtime when snow melts and the temperature oscillates around the freezing point, mainly caused by events within classes of low-frequency slope quakes and tremors. The clear link between annual temperature variations and microseismic activity could be confirmed, supporting thawing and freezing processes as the origins. Other events such as high-frequency and successive slope quakes occur throughout the year and are potentially related to the steady creep of the sliding plane. The huge variability in the annual event number cannot be solely explained by average temperatures or varying detectability of the network. Groundwater recharge processes and their response to precipitation episodes are known to be a major factor of sliding at Åknes, but the relationship with microseismic activity is less obvious and could not be demonstrated.
Hydrological modeling using the Soil and Water Assessment Tool in urban and peri-urban environments: the case of Kifisos experimental subbasin (Athens, Greece)
Authors: Koltsida Evgenia , Mamassis Nikos , Kallioras Andreas
Published: February 2023

Abstract. SWAT (Soil and Water Assessment Tool) is a continuous-time, semi-distributed, river basin model widely used to evaluate the effects of alternative management decisions on water resources. This study examines the application of the SWAT model for streamflow simulation in an experimental basin with mixed-land-use characteristics (i.e., urban/peri-urban) using daily and hourly rainfall observations. The main objective of the present study was to investigate the influence of rainfall resolution on model performance to analyze the mechanisms governing surface runoff at the catchment scale. The model was calibrated for 2018 and validated for 2019 using the Sequential Uncertainty Fitting (SUFI-2) algorithm in the SWAT-CUP program. Daily surface runoff was estimated using the Curve Number method, and hourly surface runoff was estimated using the Green–Ampt and Mein–Larson method. A sensitivity analysis conducted in this study showed that the parameters related to groundwater flow were more sensitive for daily time intervals, and channel-routing parameters were more influential for hourly time intervals. Model performance statistics and graphical techniques indicated that the daily model performed better than the subdaily model (daily model, with NSE = 0.86, R2 = 0.87, and PBIAS = 4.2 %; subdaily model with NSE = 0.6, R2 = 0.63, and PBIAS = 11.7 %). The Curve Number method produced higher discharge peaks than the Green–Ampt and Mein–Larson method and better estimated the observed values. Overall, the general agreement between observations and simulations in both models suggests that the SWAT model appears to be a reliable tool to predict discharge in a mixed-land-use basin with high complexity and spatial distribution of input data.
Earthquake hazard characterization by using entropy: application to northern Chilean earthquakes
Authors: Posadas Antonio , Pasten Denisse , Vogel Eugenio E. , Saravia Gonzalo
Published: February 2023

Abstract. The mechanical description of the seismic cycle has an energetic analogy in terms of statistical physics and the Second Law of Thermodynamics. In this context, an earthquake can be considered as a phase transition, where continuous reorganization of stresses and forces reflects an evolution from equilibrium to non-equilibrium states and we can use this analogy to characterize the earthquake hazard of a region. In this study, we used 8 years (2007–2014) of high-quality Integrated Plate Boundary Observatory Chile (IPOC) seismic data for >100,000 earthquakes in northern Chile to test the theory that Shannon entropy, H, is an indicator of the equilibrium state of a seismically active region. We confirmed increasing H reflects the irreversible transition of a system and is linked to the occurrence of large earthquakes. Using variation in H, we could detect major earthquakes and their foreshocks and aftershocks, including 2007 MW 7.8 Tocopilla earthquake, 2014 MW 8.1 Iquique earthquake, and the 2010 and 2011 Calama earthquakes (MW 6.6 and 6.8, respectively). Moreover, we identified possible periodic seismic behaviour between 80 and 160 km depth.
COMPLICAÇÕES RELACIONADAS AO USO DO CATETER CENTRAL DE INSERÇÃO PERIFÉRICA: REVISÃO INTEGRATIVA DE LITERATURA
Authors: Pina Tainá de Vasconcelos , Costa Natan Carlos da Cunha , Ferreira Elaine Barros , Rocha Priscilla Roberta Silva
Published: February 2023

Objetivo: identificar as complicações relacionadas ao uso de Cateter Central de Inserção Periférica (PICC). Método: revisão integrativa da literatura, cuja busca foi realizada nas bases Cinahl, Cochrane, Embase, BVS/Medline, Pubmed em 07/07/21, pela combinação de MESH terms e operadores booleanos AND para descritores diferentes e OR para descritores similares.  Os estudos incluídos foram avaliados e categorizados de acordo com nível de evidência. Resultados: foram recuperados 904 estudos, 7 foram incluídos. As complicações foram classificadas em locais (flebite, infecção e trombose) em 6 (85,7%) estudos; as sistêmicas (bacteremia) em 1 (14,3%) estudo e circunstanciais (oclusão, mau posicionamento, ruptura, remoção acidental, sangramento, dermatite, quebra externa e hematoma) em 5 (71,4%) estudos. Identificaram-se cuidados relacionados à prevenção, ao diagnóstico e tratamento. Conclusão: nessa revisão foi identificado uma baixa incidência de complicações relacionadas ao uso do PICC, dentre as mais frequentes foram  posicionamento inadequado (9,6%), oclusão (8,8%), flebite (8,3%), remoção acidental (4,9%) e infecção (4,3%).  Cuidados para prevenção e diagnóstico precoce de complicações são fundamentais no manejo destes dispositivos.
Colores nazaríes. Patrones de uso y dimensión cultural de los términos de color en la Iḥāṭa de Ibn al-Jaṭīb
Authors: Jreis Navarro Laila M.
Published: February 2023

El presente estudio aborda el análisis del uso de los términos de color en el diccionario bio-bibliográfico al-Iḥāṭa fī ajbār Garnāṭa, del intelectual andalusí del siglo XIV Lisān al-Dīn Ibn al-Jaṭīb. El objetivo es la reconstrucción de la categoría cultural del COLOR en el contexto del reino nazarí de Granada a través de su codificación lingüística en el corpus digitalizado de la Iḥāṭā. Para ello, se ha echado mano de una metodología basada en un esquema de anotación que sirve como base para la minería de datos y que contempla, además de los géneros, ciertos aspectos léxicos, morfológicos y semánticos. El análisis proyecta luz sobre las frecuencias de uso y su distribución siguiendo distintos parámetros, los tipos de referentes a los que se asocian los términos de color y su dimensión cultural, los paradigmas y su aspecto morfo-semántico, entre otras cuestiones extra-lingüísticas relevantes para comprender la experiencia perceptiva del COLOR nazarí. Los resultados muestran la validez de la lingüística cultural para la reconstrucción de la experiencia cognitiva en un contexto premoderno, la influencia oriental en la formulación de esta categoría cultural nazarí y las conexiones sociales que tienen los términos de color en dicha cultura.
Skills and Employability of Graduates: The Role of Skills Development Programs in District Swat
Authors: Ilyas Muhammad , Ali Sher
Published: February 2023

This study examined the impact of skills on the graduate`s employability, with the potential moderating role of employability skills development program activities. Primary data collected through a self-administered questionnaire from randomly selected 580 graduates (those graduates who have completed their graduation during 2017 - 2022) of district Swat, Khyber Pakhtunkhwa, Pakistan was used for the empirical analysis. Descriptive statistics, unpaired t-test analysis, and OLS regression analysis confirmed the hypothesis that skills have a significant positive impact on the graduate`s employability on employed, unemployed and combined group of graduates. The results also confirmed the potential moderating role of employability skills development program activities in the process. The specific employability components like personal qualities, core skills, initiative & enterprise, and attitude & work ethics are also found significantly related to the graduate`s employability. The findings of the study suggest that higher education institutions should properly plan for employability skills development program activities during graduation and ensure the participation of the students in such activities. The study also suggests that proper mechanisms should be implemented in higher education institutions to trace the skill development of the graduates during their graduation. Finally, it is suggested that the post-graduation employability skills development programs should be market-oriented and based on employer`s requirements.
INSTABILIDADE LATERAL DE VIGAS PRÉ-MOLDADAS DE CONCRETO DURANTE O IÇAMENTO CONSIDERANDO O EFEITO DAS IMPERFEIÇÕES GEOMÉTRICAS E PRESENÇA DE ARMADURAS ATIVAS
Authors: Ribeiro Cardoso Evangelista Igor Gabriel , Vidigal de Lima Maria Cristina
Published: February 2023

RESUMO: O estudo da instabilidade de vigas pré-moldadas de concreto tem merecido maior atenção devido à vasta aplicabilidade em obras de grande porte e aos preocupantes acidentes registrados com a ruptura de vigas durante a montagem. A geometria da viga influencia diretamente no problema de instabilidade, por se tratar de elementos estruturais longos e esbeltos. Neste contexto, este trabalho analisa o comportamento estrutural de vigas durante o içamento por meio de cabos de aço, levando-se em conta a excentricidade lateral inicial e o posicionamento dos cabos de suspensão, considerando o comprimento dos balanços e os desvios de posicionamento das alças na seção transversal. Estes resultados são analisados com modelos teóricos disponíveis na literatura técnica para verificação das condições de segurança e pelo modelo numérico desenvolvido no programa Ansys. As análises abrangem a comparação dos fatores de segurança, bem como a comparação dos ângulos de giro, tensões e efeito da protensão em vigas pré-moldadas durante o içamento. Constata-se que as condições de içamento são mais seguras quando o manuseio é realizado com balanços e com alças posicionadas com desvios no sentido contrário à curvatura, devendo-se tomar maior cautela no caso de vigas protendidas, especialmente com relação às tensões críticas. O efeito da presença de excentricidade lateral mostrou-se tão indesejável quanto os desvios de posicionamento das alças no sentido da curvatura, para os casos analisados.
ABSTRACT: The study of the instability of precast concrete beams has deserved more attention due to broad applications in large projects and concerning accidents with beam rupture by lateral instability. The geometry of the beam influences directly in instability problem, due to long and slender structural elements. In this context, this research analyzes the structural behavior of beams during the lifting phase by steel cables, taking into account the initial lateral eccentricity and positioning of the suspension cables, considering the length of the balances and the positioning deviations of the handles in the cross-section. These results are analyzed by theoretical models available in the technical literature to verify the safety conditions and by the numerical model developed in the Ansys program. The analyzes compare safety factor, roll angle, strain and the effect of prestress in precast beams during lifting. The studies shows that lifting conditions are safer when the handling is performed with balances and with handles in the opposite direction to the curvature, but care must be taken in prestressed beams, especially in relation to critical strains. The effect of lateral instability proved to be as undesirable as the positioning deviations of the handles in the direction of curvature, for the cases analysed.
ENSAIO DE POTENCIAL DE CORROSÃO E METODOLOGIA GDE/UnB PARA ANÁLISE DA ESTRUTURA DE CONCRETO ARMADO: ESTUDO DE CASO EM LAURO DE FREITAS – BA
Authors: Ferreira Araújo Filho Jurandir , Ferreira Eleutério Silva Moises , Bueno Mariani Bruna
Published: February 2023

RESUMO: É evidente que o número de edificações com problemas associados às manifestações patológicas tem crescido nos últimos anos, seja devido às falhas congênitas, construtivas ou adquiridas. Acontece que, por vezes, o diagnóstico e prognóstico envolvem diferentes graus de incerteza e subjetividade. A metodologia GDE/UnB, complementada com ensaios de potencial de corrosão, pode ser uma alternativa interessante para uma análise mais assertiva quanto ao nível de deterioração, facilitando ações de manutenção e recuperação das estruturas de concreto. O procedimento metodológico consistiu na seleção de uma edificação e a realização de ensaio de potencial de corrosão com aplicação da metodologia GDE/UnB para quali-quantificar o nível de deterioração da estrutura. Como resultado, pôde-se identificar pontos de maior criticidade na edificação, além de zonas de maior probabilidade de corrosão dos elementos estruturais indicados pelo mapa de contorno equipotencial.
ABSTRACT: It is evident that the number of buildings with problems associated with pathological manifestations has grown in recent years, either due to congenital, constructive or acquired failures. It turns out that sometimes the diagnosis and prognosis involve different degrees of uncertainty and subjectivity. The GDE / UnB methodology, complemented with corrosion potential tests, can be an interesting alternative for a more assertive analysis regarding the level of deterioration, facilitating actions for the maintenance and recovery of concrete structures. The methodological procedure consisted of selecting a building and conducting a corrosion potential test using the GDE / UnB methodology to qualify the level of deterioration of the structure. As a result, it was possible to identify points of greatest criticality in the building, in addition to areas of greater probability of corrosion of the structural elements indicated by the equipotential contour map.
ELABORAÇÃO DOS PERFIS DAS ÁREAS VERDES DE GOIÂNIA: ANÁLISE DO USO DO SOLO E SÍNTESE DAS PRINCIPAIS CARACTERÍSTICAS DAS ÁREAS
Authors: De Oliveira Silva Maria Eduarda , Ribeiro Hugo José , Alcione Kopp Katia
Published: February 2023

RESUMO: Considerando-se o crescimento populacional, se identifica o progresso quanto à ocupação civil dentro de municípios em desenvolvimento, como em Goiânia. Este fenômeno contribui para a redução da vegetação e cede espaço a edificações, tendendo a ocasionar perdas ecológicas e ecossistêmicas. Nos anos de 1985, 2002 e 2019, utilizando-se dados de plataformas de sensoriamento remoto, foi possível, por meio do software QGIS, caracterizar a capital de Goiás quanto à ocupação, ao uso do solo e à qualidade vegetativa pelo índice NDVI. Por meio do pacote landscapemetrics, aplicado ao software RStudio, foi possível obter os valores nos anos limites para as métricas de paisagem: CA, NP, PD, ED, SHAPE e PLAND. Através dos dados obtidos, foi possível comprovar que aproximadamente 40,92% da área do município sofreu alteração no intervalo de 34 anos, sendo a maior transformação associada ao crescimento da infraestrutura urbana e à redução da pastagem, fato que se comprova ao longo do estudo, em especial, na região de perímetro urbano.
ABSTRACT: Considering population growth, progress is identified in terms of civil occupation within developing municipalities, such as in Goiânia. This phenomenon contributes to the reduction of vegetation and gives space to buildings, tending to cause ecological and ecosystemic losses. In 1985, 2002 and 2019, using data from remote sensing platforms, it was possible, through QGIS software, to characterize the capital of Goiás in terms of occupation, land use and vegetative quality using the NDVI index. Through the land scape metrics package, applied to the RStudio software, it was possible to obtain the values in the limit years for the landscapemetrics: CA, NP, PD, ED, SHAPE and PLAND. Through the data obtained, it was possible to prove that approximately 40.92% of the municipality's area underwent changes in the 34-year interval, with the greatest transformation being associated with the growth of urban infrastructure and the reduction of pasture, a fact that is proven throughout the study, especially in the urban perimeter region.
Assesment of Fiscal Decentralization of the RA Local Self-Government System
Authors: MOVSISYAN MANUK , KARAPETYAN TSOVINAR , OHANYAN TAGUHI , MINASYAN ANNA
Published: February 2023

Despite being widely used and well examined, fiscal decentralization is often
perceived differently. Like other types of decentralization, fiscal decentralization means
the transfer of powers and responsibilities from the central government level to local selfgovernment bodies with a certain degree of autonomy.
The effectiveness of fiscal decentralization is primarily determined by the approaches
used to allocate revenues to the budgets of different levels of government, as well as by
the organization of interbudgetary relations.
It is obvious that compliance of fixed revenues (first of all tax revenues) with the
expenditure part of the budget is of great importance for the implementation of spending
powers assigned to local self-government bodies.
In the given paper, by calculating the indicators used in domestic and international
professional literature, an evaluation and analysis of the level of tax autonomy and fiscal
decentralization of the RA local self-government bodies was carried out, making
comparisons with European countries
Engineering Ecosystems and Promoting Innovation in Industry․ International Experience, Legislation, Development Tendencies
Authors: KTOYAN ARMEN , MANUKYAN YELENA , SHIRINYAN ANUSH , MATINYAN ANNA , HARUTYUNYAN MARIAM , GHALAYAN TIGRAN
Published: February 2023

The imperative need not to be left out of the processes taking place in the world economic system testifies the importance of reorganizing the sectoral structure of Armenian industry, increasing the share of high-tech, scientific spheres in it. It is obvious that the state has a special role in that. Effective implementation of innovation-based industrial policies requires the establishment of a system in which new knowledge can be effectively transformed into new technologies, products and services that will find their true buyers in domestic, regional and global markets. The role of the state in the formation of an innovative system in industry can be both passive, limited to the implementation of relevant legislative reforms, and active, in addition to legislative changes, assuming active participation in the process of establishing innovative infrastructure, new institutional units and partnerships with private investors.
The Vision of Complex Development of Syunik and Vayots Dzor Marzes of RA
Authors: KHACHIKYAN SOS , GHAZARYAN ARMEN , MKRTCHYAN ANAHIT , SARGSYAN ANDRANIK , ASLANYAN GEVORG
Published: February 2023

The southern part of the Republic of Armenia, the regions of Syunik and Vayots Dzor, have certain features: We are talking about the geographical position of this region, especially in connection with the events taking place after the second Artsakh war, as well as the economic structure. In particular, the share of the mining industry in the economic performance of Syunik region differs significantly from other regions, as a result of which the structural indicators of the economy of the region are practically not compared with other regions in the same context. The features of Vayots Dzor are due, first of all, to the infrastructural connection with Syunik region (Iran-Armenia highway, gas and electricity supply systems), as well as the new situation that has developed around the eastern borders. Commonalities both in terms of infrastructure and eastern borders are important factors for an integrated consideration of the development plans and conceptual approaches of these areas.
Hidradenitis Suppurativa: Surgery, Lasers, and Emerging Techniques
Authors:   Dr. Phillip Frost Department of Dermatology & Cutaneous Surgery University of Miami Miller School of Medicine, Miami, FL, USA, Bermudez Narges Maskan , Hargis Abby ,   Dr. Phillip Frost Department of Dermatology & Cutaneous Surgery University of Miami Miller School of Medicine, Miami, FL, USA, Yaghi Marita ,   Dr. Phillip Frost Department of Dermatology & Cutaneous Surgery University of Miami Miller School of Medicine, Miami, FL, USA, Lev-Tov Hadar ,   Dr. Phillip Frost Department of Dermatology & Cutaneous Surgery University of Miami Miller School of Medicine, Miami, FL, USA
Published: February 2023

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder that is characterized by painful nodules, abscesses and tunnels in skin folds. Current management of HS often requires a multidisciplinary approach, including medical, procedural, surgical, and psychosocial intervention. Here we review surgical techniques for the treatment of HS. While many surgical options are available for patients with HS, it is imperative that surgical planning focuses on medical optimization, patient risk factors, disease severity, and patient preferences to achieve the best outcomes.
PENGARUH PROFITABILITAS, LEVERAGE, KEPEMILIKAN INSTITUSIONAL, UKURAN PERUSAHAAN DAN KEBIJAKAN DIVIDEN TERHADAP MANAJEMEN LABA PADA PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BURSA EFEK INDONESIA TAHUN 2013-2018
Authors: Abel Enricko Gustin , Wibowo Agus Satrya , Angela Leliana Maria
Published: February 2023

The purpose of this study is to determine the impact of profitability, leverage, institutional ownership, company size, and dividend policy on earnings management by measuring discretionary reserves. In agency theory, the problem of agency is caused by the opportunistic behavior of agents, that is, the behavior of corporate executives who maximize their own wealth as opposed to their principals. Managers are tempted to select and implement accounting methods that demonstrate quality of performance in order to receive bonuses from their clients. The method used by management is called profit management. This kind of research is empirical. Sampling technique with targeted sampling. Data collection techniques through documented methods. The survey is conducted by the Indonesia Stock Exchange. Sampling is a manufacturing company listed on the Indonesian Stock Exchange from 2013 to 2018. The data analysis technique used is bilinear regression analysis. Use discretionary provisioning data to measure profit management and return on investment (ROI) to measure profitability. Use Ratio (DPR). As a result, we found that the company's variable profitability, institutional ownership and size adversely affected profit management. Leverage variables and dividend policies are actively based on profit management
A Mathematical Algorithm Approach for Estimating Water-Based Paint Requirements for a Given Wall
Authors: Gambi Costance , Taifa Ismail
Published: February 2023

The research aimed to improve the accuracy of estimating water-based paint requirements for a given wall using mathematical algorithms. The approach used in this study included a survey and document review to obtain details concerning paint. The study focused on water-based paints, including silk, weather guard, emulsion hi-cover and polyvinyl acetate (PVA) roof paint used in Tanzania’s building and construction industry. Data collected from the field study were analysed systematically. It was observed that there is a high level of familiarity in improving the accuracy of estimation of the required water-based paints, namely silk, weather guard, emulsion hi-cover and PVA roof paint for a given wall. The algorithm validation was performed by benchmarking the pre-established algorithms. Validation involved conducting five experiments: the physical study by applying two paint coats on a wall and recording the results. The percentage errors of a painting by approximating the paint using the algorithm developed gives better results than that from the different projects held in Tanzania, which was taken as a sample. The novelty of this study is based on the developed mathematical algorithm. In fact, this is among the fewer studies that mainly improve the accuracy of estimating the paint required for a given wall using a mathematical algorithm in Tanzania. There are limited studies of that nature as the majority use experience, which result in higher discrepancies.
Formulation and Evaluation of Mucoadhesive Tablets of Acarbose for Type 2 Diabetes
Authors: Jisha N.M. Ameera
Published: February 2023

The objective of the study was to develop mucoadhesive tablet of Acarbose (α-glycosidase inhibitor) to enhance the bioavailability and to further reduce the dosing frequency of administration. The Mucoadhesive tablets of Acarbose were prepared by using three different Mucoadhesive polymers such as HPMC E5 LV, Sodium alginate and Guar Gum in varying concentrations and by direct compression technique. The micromeritics evaluation such as angle of repose, bulk density, tapped density, compressibility index and Hausner's ratio showed good to satisfactory flow properties. Swelling index was calculated with respect to time. The swelling index profile of all formulations, prepared as per the experimental design showed an increase in the value of swelling index as the amount of polymer increased. Maximum swelling index was found seen with formulations containing Sodium alginate, the value increases with increasing the amount of sodium alginate. The highest adhesion force i.e. highest strength of mucoadhesive bond was observed with Formulation F9 containing Guar gum as 18.02±0.17 this followed by F6 containing Sodium alginate as 16.33±0.56 and formulation F8 containing Guar gum in the ratio 1:2 as 14.26±0.11. The Adhesion Force increases with increasing the concentration of Mucoadhesive polymers used. The Tablets containing HPMC E5 LV showed least adhesive force than tablets of other formulations. The formulation F6 containing Sodium alginate was taken as optimized formulation based on its mucoadhesive strength and in vitro release was found to be optimum. The optimized formulation was subjected to kinetic drug release studies. The formulation best fitted into zero order kinetics. The drug release was dominated by the erosion and swelling of the polymer. From the release exponent in the Korsmeyer-Peppas model it could be suggested that the mechanism that leads to the release of drug was non-Fickian diffusion.

Keywords: mucoadhesive tablet, Acarbose, Gastroretentive
THE USE OF IMMUNE CHECKPOINT INHIBITORS IN TREATING LOCALLY ADVANCED AND METASTATIC GASTRIC CANCER: A LITERATURE REVIEW
Authors: Dmitrenko M. , Smagulova K. , Abdrahmanov R. , Raskaliev R. , Turkpenova I. , Medetbekova E. , Kaldarbekov S. , Kuanysh A. , Kenzhebayeva Z. , Shayakhmetova D. , Zhiyenbayeva A. , Dzhakipbaeva A.
Published: February 2023

Relevance: Gastric cancer is one of the most common malignant neoplasms and ranks fifth in cancer incidence worldwide. The only curative approach to localized gastric cancer is radical surgery with or without prior chemotherapy. But chemotherapy is the main treatment method for metastatic or locally advanced gastric cancer. Later stages of gastric cancer are highly resistant to chemotherapy; therefore, there is a need for modern treatment approaches. Particular attention is paid to therapy for metastatic/locally advanced gastric cancer.

The study aimed to describe the possibilities of using immune checkpoint inhibitors (ICIs) to treat metastatic or locally advanced gastric cancer.

Methods: The data from modern literary sources of recent years were studied using specialized scientific search engines: Scopus, PubMed, Google Scholar, and Web of Science for the possibility of promising application of various immunotherapeutic approaches in treating metastatic or locally advanced gastric cancer.

Results: The article describes modern methods of treatment of metastatic or locally advanced SC using ICIs, including PD-1, PD-L1, and CTLA-4, demonstrates the mechanisms of immunological surveillance, characteristics of PD-1, PD-L1, CTLA-4, and their significance in suppressing the T-cell response. The effectiveness of using ICIs, particularly PD-1, PD-L1, and CTLA-4, has been established in the first and subsequent lines of therapy.

Conclusion: ICIs are a recent finding in antitumor therapy. Frequent resistance of gastric cancer to chemotherapy urges the use of ICIs to treat advanced gastric cancer.
Tinjauan Yuridis Tindak Pidana Perbankan Yang Berkaitan Dengan Usaha Bank (Studi Kasus Putusan Pengadilan Nomor 2644/Pid.b/2021/PN Mdn)
Authors: Wulandari Asry Silvia
Published: February 2023

This juridical review aims to determine the factors that cause banking crimes at banks in tackling banking crimes against banking crimes at banks. This juridical review uses a normative approach, namely by focusing on the study of regulations relating to banking crimes related to bank business. In addition, this study was carried out through juridical activities. This research was conducted by examining banking crimes related to bank business. The results of this juridical review show that the factors that lead to banking crimes at banks are economic factors, opportunity factors, and technological development factors.
Pengaruh Lingkungan Kerja, Profesionalisme dan Kepuasan Kerja Terhadap Komitmen Kerja Pada Unit Penyelenggara Bandar Udara (UPBU) Kelas I Mopah Merauke
Authors: Gautama Indra , Suratini Suratini , Noviyanti Mery
Published: February 2023

In theory, work commitment can be influenced by various factors, including the work environment, professionalism, and job satisfaction. Research on work commitment in the airport sector managed by the government is still very rare, therefore the purpose of this study is to determine the effect of the work environment, professionalism, and job satisfaction on employee work commitment at the Class I Mopah Merauke Airport Operations Unit (UPBU). with a population of 110. The sample determination method uses a saturated sample, so that all employees at the UPBU Class I Mopah Office are used as samples. Variable measurements were carried out using a Likert scale. Data analysis was performed using multiple linear regression methods and with SPSS software. The results of the analysis show that the work environment, work professionalism, and job satisfaction have a significant positive effect on employee work commitment in Class I UPBU Mopah Merauke Office. The better the work environment, work professionalism, and job satisfaction, it will lead to better work commitment.
Crystallization behavior and structural evaluation of cordierite base glass-ceramic in the presence of CaO and B2O3 additives
Authors: Shamohammadi Ghahsareh Zahra , Rezvani Mohammad
Published: February 2023

The purpose of the present work is to highlight the role of CaO and B2O3 additives on the crystallization behavior and microstructural properties of stoichiometric cordierite glass-ceramics using differential thermal analysis (DTA), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Vickers micro-hardness and scanning electron microscopy (SEM). The results show that the presence of B2O3 and CaO in the initial glass led to the precipitation of only one exothermic peak (α-cordierite: Mg2Al4Si5O18). During the heat treatment process, the presence of calcium oxide favors crystallization of anorthite (CaAl2Si2O8) besides α-cordierite phase. It is worth mentioning that, CaO and B2O3 additives strongly encourage the formation of α-cordierite and have the opposite effect on the crystallization of μ-cordierite. In order to determine the effect of crystallization and B2O3 and CaO additives on the hardness of specimens, the micro-hardness measurement of glasses and glass-ceramics shows that the glass-ceramic containing CaO (MAS5C) exhibits the highest micro-hardness value, which depends on the high crystallinity value in this specimen.
SMEs and Circular Economy drivers: empirical evidence from Italy
Authors: Montanaro Alessandro
Published: February 2023

The study investigates the determinants of the adoption of circular economy (CE) innovations in Italian manufacturing SMEs by using original data based on 4,042 firms for the 2017-2018 period. Results indicate that firms’ innovative efforts, size, export activity, management’s environmental awareness as well as the use of the digital innovation policy, Piano Industria 4.0, are factors that are positively correlated with the adoption of general CE innovations, showing heterogeneous results across different circular economy practices.
Art on the Moon, Poetry for Homo spaciens: An Interview with Eduardo Kac about His Artwork Adsum
Authors: Osthoff Simone
Published: February 2023

This interview focuses on Eduardo Kac’s new artwork-poem Adsum, a laser-etched glass sculpture created for the lunar environment. From the work’s enigmatic title to its five stages of development involving NASA spacecraft, cosmic tests, as well as micro, human, and cosmic scales, the artist considers the following questions: How do you create a meaningful visual composition at the threshold of visibility? How do you write with symbols in a manner that is not dictated by Earth gravity? How do you consciously forward a message into the future while maintaining the ability to communicate contemporaneously?
The University of Wisconsin and the Development of Librarianship in the Philippines
Authors: Brazzeal Bradley
Published: February 2023

The Spanish-American War of 1898 ushered in an era of American rule over the Philippines that formally ended in 1946. An expansive colonial government developed with Americans filling most professional positions early on. There was a slow transition to Filipinos holding those positions, and this process can be seen in the field of librarianship. By the middle of 1924 library leadership and the teaching of library science was firmly in the hands of Filipinos. The University of Wisconsin and those associated with the institution, both Americans and Filipinos, played leading roles in the development of Philippine librarianship. This article explores this special relationship, focusing on the pre–World War II era.
Prospective Evaluation of Low-Fat Diet Monotherapy in Dogs with Presumptive Protein-Losing Enteropathy
Authors: Myers Marc , Martinez Stephen A. , Shiroma Jonathan T. , Watson Adam T. , Hostutler Roger A.
Published: February 2023

For dogs with protein-losing enteropathy (PLE) and evidence of lymphangiectasia, the efficacy of low-fat diet as monotherapy or combined with prednisone remains poorly characterized. In this prospective, observational cohort study of 14 dogs with presumptive PLE and ultrasonographic evidence of lymphangiectasia, subjects were placed on various low-fat diets as monotherapy and prednisone was added if response was deemed inadequate. Dogs were assessed and scored at four recheck examinations across a 6 mo study period, including a final recheck ultrasound. Clinical and clinicopathologic variables were collected and dogs were divided into three outcome groups: clinical remission on dietary monotherapy (LOF); clinical remission on dietary therapy plus immunosuppressive prednisone (LOP); and treatment failure (TXF). Eleven of 14 dogs were in clinical remission at the study end date (6 mo after enrollment): 6 LOF dogs and 5 LOP dogs. LOF dogs achieved a significant reduction in Canine Chronic Enteropathy Clinical Activity Index score and a significant increase in serum albumin within 2 wk of beginning dietary monotherapy. Four of 11 dogs in remission also had ultrasonographic evidence of resolution of linear striations. Low-fat diet appears to be an effective monotherapy in some dogs with presumptive PLE and ultrasonographic evidence of lymphangiectasia.
Karaahmetli Tabiat Parkı’nın Rekreasyon Potansiyelinin Değerlendirilmesi
Authors: BİNGÜL BULUT M. Bihter
Published: February 2023

Bir alanın rekreasyon değeri o alanın mevcut çevre koşulları ve sahip olduğu doğal ve kültürel peyzaj özellikleri değerlendirilerek belirlenir. Mevzuatta Tabiat Parkı olabilme kriterlerinde belirtilen ‘rekreasyon potansiyeline sahip olması’ ifadesinden yola çıkarak tabiat parklarının rekreasyon potansiyeli üzerine yapılan çalışmalar ulusal literatürde mevcuttur. Ancak bu çalışmanın materyali olan Karaahmetli Tabiat Parkı’nda böyle bir çalışma yapılmamıştır. Bu çalışma kapsamında, Karaahmetli Tabiat Parkı’nın rekreasyon potansiyeli Gülez yöntemi ile hesaplanmıştır. Çalışma yerinde gözlem, yetkililerle görüşme ve uzman görüşlerine dayalı olarak gerçekleştirilmiştir. Doğal ve kültürel bileşenler (peyzaj değeri, iklim değeri, ulaşılabilirlik ve olumsuz etkiler) değerlendirilerek Karaahmetli Tabiat Parkı’nın %70 rekreasyon potansiyeline sahip olduğu saptanmıştır. Tabiat parklarının rekreasyonel potansiyelinin değerlendirilmesi doğa koruma ve kentsel planlama süreçlerinde ve rekreasyon ve turizm planlama süreçlerinde karar vermeye yardımcı olmaktadır. Ayrıca hangi ekosistem bileşenlerinin rekreasyon fırsatlarının sağlanmasına katkıda bulunduğuna odaklanan rekreasyonel ekosistem hizmetleri çalışmalarıyla entegre edilerek, doğal çevrenin açık hava rekreasyonunun faydalarına ve sonuçlarına nasıl katkıda bulunduğuna dair anlayışımızı geliştirebilir.
Epikureanisme dan Stoikisme: Etika Helenistik Untuk Seni Hidup Modern
Authors: Carlos Kodoati Michael
Published: February 2023

Epicureanism and Stoicism are two of all Greek philosophies which aim to answer the question of what man seeks for himself. Aristotle has already answered it as happiness (eudaimonia). In addition to discussing the Stoics as an art of living, this study wants to try to see the needs of Modern Ethics for Hellenistic Ethics. Stoics and Epicureanism want to be juxtaposed as both contradictory, hostile and different Hellenistic Ethics but can be used as a way of how modern man seeks his happiness. Using several quotes from Epictetus, in the end this research wants to show that to achieve happiness humans can try not to make representations, talk about what is factual and act indifferently, while still paying attention to the logical aspect.
Generasi Hamba Google: Saya Klik maka Saya Pintar
Authors: Florentina Rumba Maria , Yulianus Yosafat
Published: February 2023

This paper aims to offer a critical discussion regarding the advancement of digital technology. The author directs attention to the so-called generation z who have lost control of using digital technology. The critical ideas offered aim to educate the younger generation, who live in a 'click' mentality and have become Google's slaves. This critical discussion also aims to build a critical and responsible intellectual attitude in the digital era. The author designed this research as a literature review. Amid the rapid advancement of digital technology, generation z must remain critical and not become a Google slave. Flexibility and adaptability in a changing world must be accompanied by an attitude of responsibility. They must have the ability to give value to their activities in digital technology. Technological literacy must be balanced with self-discovery. Literacy culture is a solution to achieve a critical awareness and an attitude of responsibility in dealing with advanced digital technology.
Membangun Gereja yang Mendengarkan. Belajar dari Keuskupan Manado
Authors: Hertanto Dwi Wibowo Gregorius , Sujoko Albertus , Wuritimur Amrosius
Published: February 2023

This article aims to reveal several points regarding the quality of listening in building a synodal Church by learning from listening experiences among the Catholics of Manado Diocese. By using a phenomenological approach, we want to describe the experiences of Catholics in listening interactions in their lives of faith, and how people interpret that experience. The data collection was obtained in conjunction with the focus group discussion process which was carried out in this diocese ahead of the 2023 Synod of Bishops. It was found that both positive qualities and challenges can be found in various communities, lay and clergy, leaders of the people and the people they lead. By carefully appreciating these aspects in the light of Church models, the article provides strategic suggestions for reflection and pastoral action not only in Manado Diocese but also for the wider Church to build a better listening Church.
Konsep Jiwa Perspektif Ibnu Sina
Authors: Putri Serena Debi , Umi Hani Siti , Septria Vionita Bunga , Sohim Badru
Published: February 2023

The purpose of this essay is to clarify Ibn Sina's views on the spirit and its connection to the body. A qualitative approach is used in this research to conduct a review of the literature. This study's methodology is an investigation into Islamic literacy using both main and secondary data sources. The body and the soul are different entities or made up of diverse materials, according to Ibn Sina. The soul is not gone when the body is destroyed. The soul lasts forever. Even though the body and the soul are made up of distinct substances, they are both interdependent. It is impossible to separate the soul from the body. The tendency of western philosophical thought toward dualism of soul and body is overcome by Ibn Sina's idea. The relationship between both the body and the spirit demands.
Efektivitas Penggunaan Aplikasi Prezi Terhadap Kemampuan Bercerita Anak Usia Dini di Taman Kanak-kanak Kartika 1-7 Padang
Authors: Warrizqi Iftitahurrahmi , Marlina Serli
Published: February 2023

Penelitian ini dilatarbelakangi oleh rendahnya kemampuan bercerita anak di sekolah tersebut. Penelitian ini punya tujuan guna mengetahui bagaimana efektivitas efektivitas penggunaan aplikasi prezi terhadap kemampuan bercerita anak usia dini di Taman Kanak-kanak Kartika 1-7Padang. Jenis penelitian ini memakai pendekatan kuantitatif sementara metodenya quasi eksperimen. Penelitian dijalankan di TK Kartika 1-7 Padang dengan melakukan di dua kelas, yakni kelompok eksperimen kelas B1 sebanyak 13 anak serta kelompok kontrol kelas B5 sebanyak 13 anak. Teknik dalam mengumpulkan data menggunakan instrument penelitian berupa indikator-indikator yang akan dicapai sebanyak 9 butir item, yang dilakukan melalui tes perbuatan. Teknik analisis data memakai uji normalitas, homogenitas serta hipotesis. Alat pengumpul data digunakan lembaran pernyataan. Kemudian data diolah dengan uji perbedaan (t-test) menggunakan bantuan aplikasi SPSS 15.0 for windows. Didasarkan analisis data, hasil rata-rata pre-test serta post-test kelompok eksperimen ialah 20,15 serta 27,38. Sementara pada kelompok kontrol, rata-rata hasil pre-test serta post-test adalah 20,62 dan 25,00. Data yang dihasilkan berdistribusi normal serta homogen. Pada uji hipotesis dengan Independent sample t-test nilai sig (2- tailed) 0,000 yaitu lebih kecil dari 0,05. Dapat disimpulkan bahwa media aplikasi prezi terbukti lebih efektif terhadap  kemampuan bercerita anak.
Rezension von: Chandrinos, Iason; Mall, Volker, "Wir waren Menschen zweiter Klasse"
Authors: Setzler Wilfried , Chandrinos Iasonas , Mall Volker
Published: February 2023

Iason Chandrinos und Volker Mall: »Wir waren Menschen zweiter Klasse«. Die Geschichte der 1040 im Sommer 1944 von Athen nach Deutschland deportierten Griechen Hrsg. von der KZ Gedenkstätte Hailfingen/ Tailfingen. BoD – Books on Demand Norderstedt 2022. 598 Seiten mit einigen Abbildungen. Hardcover 39,00 €. ISBN 978-3-7562-0486-1
Rezension von: Landesamt für Denkmalpflege im Regierungspräsidium Stuttgart (Hrsg.), Junge Unis in Baden-Württemberg ...
Authors: Langner Bernd , Landesamt für Denkmalpflege Regierungsbezirk Stuttgart.
Published: February 2023

Junge Unis in Baden-Württemberg. Hochschulbauten der Nachkriegs- und Postmoderne. Hrsg. vom Landesamt für Denkmalpflege im Regierungspräsidium Stuttgart (Arbeitsheft 45). Jan Thorbecke Verlag Ostfildern 2022. 240 Seiten, farbig illustriert. Broschur 30,00 €. ISBN 978-3-79951-576-4

wohnen 60 70 80: Junge Denkmäler in Deutschland. Hrsg. von der Vereinigung der Landesdenkmalpfleger in der Bundesrepublik Deutschland. Deutscher Kunstverlag Berlin/München 2020. 224 Seiten, illustriert. Gebunden 39,80 €. ISBN 978-3-42298-154-6
Rezension von: Knittel, Anton Philipp, (Hrsg.) Ludwig Pfau
Authors: Maier Ulrich , Knittel Anton Philipp
Published: February 2023

Anton Philipp Knittel (Hrsg.): Ludwig Pfau. Revolutionsliteratur im deutschen Südwesten (Forum Vormärz-Forschung e.V., Vormärz-Studien 44). Aisthesis Verlag Bielefeld 2022. 225 Seiten mit 18 Abbildungen. Paperback 30,00 €. ISBN 978-3-8498-1796-1