bluuebunny/crossref_metadata_2025 huggingface dataset:
Neurogenic orthostatic hypotension after treatment with sorafenib
Authors: Wegner Wippel Catherine , Deshpande Hari , Patwa Huned , Peixoto Aldo J
Published: December 2022

A man in his 70s with a history of fatigue, abdominal pain, and a palpable abdominal mass was found to have a peritoneal desmoid tumour. One year after diagnosis, he was prescribed sorafenib to limit tumour growth. Two months later, he developed dyspnoea on exertion and lower extremity weakness and was reported to have supine hypertension and orthostatic hypotension. On formal autonomic testing, he was noted to have severely impaired sympathetic responses and marked orthostatic hypotension without appropriate chronotropic response. A decision to hold sorafenib was made, and treatment was started with graduated compression stockings, liberal fluid and sodium intake, and midodrine. The patient had a modest and gradual improvement in his symptoms. To our knowledge, this is the first reported case of orthostatic hypotension related to sorafenib or any vascular endothelial growth factor inhibitors.
Spontaneous and simultaneous rupture of both Achilles tendons in a haemodialysis patient
Authors: Masmoudi Karim , Khlifi Maher , Jameli Kaouther , Jellali Hatem
Published: December 2022

This case involved a male patient in his 30s who sustained a spontaneous and simultaneous bilateral rupture of the Achilles tendons. His medical history was significant for end-stage renal failure for which he had been undergoing haemodialysis for 13 years, and parathyroidectomy 2 years before this presentation. The patient underwent an open repair of both Achilles tendons using gastrocnemius augmentation with a favourable final outcome. The radical control of secondary hyperparathyroidism in haemodialysis patients does not protect the patient from the occurrence of spontaneous tendon rupture in all cases.
VEXAS syndrome with progression of MDS to MDS/MPN overlap syndrome
Authors: Neupane Karun , Jayarangaiah Apoorva , Zhang Yan , Kumar Abishek
Published: December 2022

VEXAS (vacuoles, E1 enzyme, X linked, autoinflammatory, somatic) syndrome is a novel inflammatory syndrome that was first described in December 2020. Patients with VEXAS syndrome have a somatic mutation in the UBA1 gene, inflammatory conditions and usually haematological conditions. Haematological conditions reported in patients with VEXAS syndrome include myelodysplastic syndrome (MDS), clonal cytopenia of undetermined significance, plasma cell neoplasm including multiple myeloma/monoclonal gammopathy of undetermined significance, haemophagocytic lymphohistiocytosis and monoclonal B-cell lymphocytosis. Here we describe a patient with VEXAS syndrome who had a progression of MDS to MDS/myeloproliferative neoplasm overlap syndrome. The ocular findings so far reported in these patients include episcleritis, uveitis, blepharitis and orbital cellulitis. Here we report retinal detachment as a clinical feature of VEXAS syndrome. This finding has a significant implication in patient management as it warrants higher vigilance for this sight-threatening complication.
Acinar cell carcinoma with PRKAR1A and PTEN alterations and paraneoplastic panniculitis
Authors: Yang Zhizhou , Zarate Rodriguez Jorge G , Beck Haley , Byrnes Kathleen , Trikalinos Nikolaos A , Hammill Chet W
Published: December 2022

Pancreatic acinar cell carcinoma is a rare type of pancreatic malignancy, which can be confused with pancreatic neuroendocrine neoplasm. Here, we describe a woman in her 80s who presented with abdominal pain and bilateral lower extremity panniculitis. She underwent surgery for a presumed diagnosis of neuroendocrine tumour with PTEN and PRKAR1A alterations; 19 months, later, a recurrence of her pancreatic malignancy was discovered. The patient underwent repeat resection and this time immunohistochemical staining confirmed the diagnosis of acinar cell carcinoma. Staining for acinar cell carcinoma should be prompted based on clinical suspicion in context of PTEN or PRKAR1A mutation when appropriate.
Sustaining improvement of hospital-wide initiative for patient safety and quality: a systematic scoping review
Authors: Moon Sarah E J , Hogden Anne , Eljiz Kathy
Published: December 2022

Background

Long-term sustained improvement following implementation of hospital-wide quality and safety initiatives is not easily achieved. Comprehensive theoretical and practical understanding of how gained improvements can be sustained to benefit safe and high-quality care is needed. This review aimed to identify enabling and hindering factors and their contributions to improvement sustainability from hospital-wide change to enhance patient safety and quality.

Methods

A systematic scoping review method was used. Searched were peer-reviewed published records on PubMed, Scopus, World of Science, CINAHL, Health Business Elite, Health Policy Reference Centre and Cochrane Library and grey literature. Review inclusion criteria included contemporary (2010 and onwards), empirical factors to improvement sustainability evaluated after the active implementation, hospital(s) based in the western Organisation for Economic Co-operation and Development countries. Numerical and thematic analyses were undertaken.

Results

17 peer-reviewed papers were reviewed. Improvement and implementation approaches were predominantly adopted to guide change. Less than 6 in 10 (53%) of reviewed papers included a guiding framework/model, none with a demonstrated focus on improvement sustainability. With an evaluation time point of 4.3 years on average, 62 factors to improvement sustainability were identified and emerged into three overarching themes: People, Process and Organisational Environment. These entailed, as subthemes, actors and their roles; planning, execution and maintenance of change; and internal contexts that enabled sustainability. Well-coordinated change delivery, customised local integration and continued change effort were three most critical elements. Mechanisms between identified factors emerged in the forms of Influence and Action towards sustained improvement.

Conclusions

The findings map contemporary empirical factors and their mechanisms towards change sustainability from a hospital-wide initiative to improve patient safety and quality. The identified factors and mechanisms extend current theoretical and empirical knowledgebases of sustaining improvement particularly with those beyond the active implementation. The provided conceptual framework offers an empirically evidenced and actionable guide to assist sustainable organisational change in hospital settings.
Dysregulated carbohydrate and lipid metabolism and risk of atrial fibrillation in advanced old age
Authors: Pellegrini Cara N , Buzkova Petra , Oesterle Adam , Heckbert Susan R , Tracy Russell P , Siscovick David S , Mukamal Kenneth J , Djoussé Luc , Kizer Jorge R
Published: December 2022

Objective

Obesity and dysmetabolism are major risk factors for atrial fibrillation (AF). Fasting and postload levels of glucose and non-esterified fatty acids (NEFAs) reflect different facets of metabolic regulation. We sought to study their respective contributions to AF risk concurrently.

Methods

We assessed levels of fasting and postload glucose and NEFA in the Cardiovascular Health Study to identify associations with AF incidence and, secondarily, with ECG parameters of AF risk available at baseline. Linear and Cox regressions were performed.

Results

The study included 1876 participants (age 77.7±4.4). During the median follow-up of 11.4 years, 717 cases of incident AF occurred. After adjustment for potential confounders, postload glucose showed an association with incident AF (HR per SD increment of postload glucose=1.11, 95% CI 1.02 to 1.21, p=0.017). Both glucose measures, but not NEFA, were positively associated with higher P wave terminal force in V1 (PTFV1); the association remained significant only for postload glucose when the two measures were entered together (β per SD increment=138 μV·ms, 95% CI 15 to 260, p=0.028). Exploratory analyses showed significant interaction by sex for fasting NEFA (pinteraction=0.044) and postload glucose (pinteraction=0.015) relative to AF, with relationships stronger in women. For postload glucose, the association with incident AF was observed among women but not among men.

Conclusions

Among older adults, postload glucose was positively associated with incident AF, with consistent findings for PTFV1. In exploratory analyses, the relationship with AF appeared specific to women. These findings require further study but suggest that interventions to address postprandial dysglycaemia late in life might reduce AF.
TIGIT blockade repolarizes AML-associated TIGIT+M2 macrophages to an M1 phenotype and increases CD47-mediated phagocytosis
Authors: Brauneck Franziska , Fischer Brit , Witt Marius , Muschhammer Jana , Oelrich Jennyfer , da Costa Avelar Pedro Henrique , Tsoka Sophia , Bullinger Lars , Seubert Elisa , Smit Daniel J , Bokemeyer Carsten , Ackermann Christin , Wellbrock Jasmin , Haag Friedrich , Fiedler Walter
Published: December 2022

Background

Leukemia-associated macrophages (LAMs) represent an important cell population within the tumor microenvironment, but little is known about the phenotype, function, and plasticity of these cells. The present study provides an extensive characterization of macrophages in patients with acute myeloid leukemia (AML).

Methods

The phenotype and expression of coregulatory markers were assessed on bone marrow (BM)-derived LAM populations, using multiparametric flow cytometry. BM and blood aspirates were obtained from patients with newly diagnosed acute myeloid leukemia (pAML, n=59), patients in long-term remission (lrAML, n=8), patients with relapsed acute myeloid leukemia (rAML, n=7) and monocyte-derived macrophages of the blood from healthy donors (HD, n=17). LAM subpopulations were correlated with clinical parameters. Using a blocking anti-T-cell immunoreceptor with Ig and ITIM domains (TIGIT) antibody or mouse IgG2α isotype control, we investigated polarization, secretion of cytokines, and phagocytosis on LAMs and healthy monocyte-derived macrophages in vitro.

Results

In pAML and rAML, M1 LAMs were reduced and the predominant macrophage population consisted of immunosuppressive M2 LAMs defined by expression of CD163, CD204, CD206, and CD86. M2 LAMs in active AML highly expressed inhibitory receptors such as TIGIT, T-cell immunoglobulin and mucin-domain containing-3 protein (TIM-3), and lymphocyte-activation gene 3 (LAG-3). High expression of CD163 was associated with a poor overall survival (OS). In addition, increased frequencies of TIGIT+M2 LAMs were associated with an intermediate or adverse risk according to the European Leukemia Network criteria and the FLT3 ITD mutation. In vitro blockade of TIGIT shifted the polarization of primary LAMs or peripheral blood-derived M2 macrophages toward the M1 phenotype and increased secretion of M1-associated cytokines and chemokines. Moreover, the blockade of TIGIT augmented the anti-CD47-mediated phagocytosis of AML cell lines and primary AML cells.

Conclusion

Our findings suggest that immunosuppressive TIGIT+M2 LAMs can be redirected into an efficient effector population that may be of direct clinical relevance in the near future.
Treat-to-target in rheumatoid arthritis: a real-world study of the application and impact of treat-to-target within the wider context of patient management, patient centricity and advanced therapy use in Europe
Authors: Taylor Peter C. , Fautrel Bruno , Piette Yves , Romero-Yuste Susana , Broen Jasper , Welcker Martin , Howell Oliver , Rottier Elke , Zignani Monia , Van Beneden Katrien , Caporali Roberto , Alten Rieke
Published: December 2022

Background

While treat-to-target (T2T) is endorsed for the management of rheumatoid arthritis (RA), data on the degree of implementation in clinical practice are limited. This study investigated the use of T2T for RA in a real-world setting across Europe.

Methods

The Adelphi RA Disease-Specific Programme was a point-in-time survey of rheumatologists and their consulting patients with RA conducted between January and October 2020 in Belgium, France, Germany, Italy, Spain and the UK. Rheumatologists completed an attitudinal survey, and a record form for their next 10–12 consulting patients, who were invited to voluntarily complete a patient-reported questionnaire. Data collected included clinical characteristics, treatment patterns and attitudes towards T2T.

Results

Overall, 316 rheumatologists provided data for 3120 patients, of whom 1108 completed the questionnaire. While 86.1% of rheumatologists estimated using T2T principles in clinical practice, only 66.6% of patients were reported by their physician to be managed using a T2T approach. Achieving disease remission was the most commonly reported treatment goal identified by rheumatologists (79.7%), followed by symptom control (47.8%) and reducing impact on quality of life (44.5%). 40.8% of rheumatologists and their patients were in agreement that a treatment goal had been set. When there was agreement on treatment goals, we observed better patient satisfaction, engagement and treatment success.

Conclusions

Despite recommendations, the T2T approach in RA appears to be suboptimally implemented in clinical practice. This highlights the importance of patient-centricity in the decision-making process to define meaningful targets and select appropriate treatments to improve disease outcomes.
Solvation thermodynamics of four amino acids in electrolytic solutions of sodium and potassium iodide salts at 298.15 K
Authors: Kundu Simanta , Mahali Kalachand , Roy Sanjay
Published: December 2022

The solubility and thermodynamics of solvation due to solute–solvent interactions of glycine, DL-alanine, DL-serine, and DL-valine were determined in this study. Mainly, the transfer of Gibbs free energies from aqueous to aqueous sodium and potassium iodide salt solutions was considered, which were calculated by direct experimental solubility data and via theoretical calculations. The equilibrium solubilities were measured at 298.15 K using simple “formol titration”. Various important physicochemical factors like enthalpy of solvation, molar volume, molar mass, molar density, etc., in aqueous electrolyte solutions were calculated at standard temperature. The thermodynamic parameters were explained to conclude about the virtual stability of the zwitterionic solutes in aqueous salt mixtures. The factors that are associated with solubility were also explained and correlated with physical and thermodynamic point of view.
Applying technical guidance from the USA for management of impacts of anthropogenic noise on wildlife in other countries: the Canadian context
Authors: Wright Andrew J. , Moors-Murphy Hilary B. , Yurk Harald
Published: December 2022

Technical Guidance from the US National Marine Fisheries Service recommends Federal agencies use estimated thresholds for peak sound pressure levels and weighted cumulative sound exposure levels for the onset of permanent (and temporary) hearing threshold shifts in marine mammals. These dual metrics were developed to inform impact assessments within the US legal landscape. Despite its merits, the Technical Guidance contains uncertainties due to limited data on marine mammal hearing and auditory response to noise. The underlying assumptions about how representative existing data are for all marine mammal species also create limitations in the applicability of the Technical Guidance. These limitations warrant consideration before the Technical Guidance can be applied effectively in other jurisdictions with different legal standards. Using the Canadian legal framework as a working example, we found that many Canadian species are underrepresented in the dataset informing the Technical Guidance. The Technical Guidance also does not address all relevant noise impact types. Thus, the Technical Guidance alone cannot address all Canadian legal standards and, if the Technical Guidance is incorporated, some adjustments to the criteria within may be needed to meet the precautionary requirements of many Canadian legal standards.
Wavelet-based numerical solution of a mathematical model on the Hydro-magnetic stagnation point flow
Authors: Kumbinarasaiah S. , Raghunatha K. R. , Inc Mustafa , Akgül Ali
Published: December 2022

The steady two-dimensional flow of an incompressible electrically conducting fluid near the stagnation point on a stretching sheet is investigated. The governing highly nonlinear PDEs are altered into highly nonlinear ODE by utilizing non-similar and similar variables and then solved numerically using a Hermite wavelet collocation method (HWCM). It is interesting to note that the results of the previous authors are in good agreement with the results of this study tabulated which is evident from the tabular values. Further, the effects of the magnetic parameter, viscoelastic parameter, stagnation point flow, and stretching of the sheet parameters on the flow field characteristics are obtained and discussed. The Lorentz force opposes the flow. Further, the fluid flow velocity decreases as the viscoelastic parameter increases. This practically indicates that the characteristics of fluid flow in viscoelastic fluids may be influenced by modifying the change in the viscoelastic parameter.
PPDA-FAF: Maintaining Data Security and Privacy in Green IoT-Based Agriculture
Authors: Jaber Mustafa Musa , Yussof Salman , Ali Mohammed Hassan , Abd Sura Khalil , Jassim Mustafa Mohammed , Alkhayyat Ahmed , Mubarak H.
Published: December 2022

Nowadays, Green IoT-Based Agriculture plays an essential role in farming to improve the yield. Here, IoT devices are embedded in the farming equipment, which helps to enhance the irrigation and yield with minimum cost-cutting. Data security and privacy are major challenges in green IoT-related agriculture. Therefore, a secured system should create to maintain data confidentiality, authentication, integrity, availability, and privacy. This system uses the privacy-preserving data aggregation (PPDA) with a Fair access framework (FAF) that manages the data security. The data aggregation concept is used to protect the green IoT data from false data injection. The FAF utilizes the blockchain technique to grant, get, revoke and delegate access to the user. The developed security system can adapt the green IoT-based agriculture and provide confidentiality, which is done with the help of an enhanced ciphertext access control mechanism. This system resolves the security and privacy issues involved in the Green IoT-based agriculture, and the effectiveness of the system is evaluated using implementation results.
An Accurate, Controllably Dissipative, Unconditionally Stable Three-Sub-Step Method for Nonlinear Dynamic Analysis of Structures
Authors: Ji Yi , Wu Yang , Xing Yufeng
Published: December 2022

An implicit truly self-starting time integration method for nonlinear structural dynamical systems is developed in this paper. The proposed method possesses unconditional stability, second-order accuracy, and controllable dissipation, and it has no overshoots. The well-known BN-stability theory is employed in the design of algorithmic parameters, ensuring that the proposed method can stably solve nonlinear structural dynamical systems without restricting the time step size. The spectral analysis shows that compared to existing second-order accurate time integration methods, the proposed method enjoys a considerable advantage in low-frequency accuracy. For nonlinear problems where the currently popular Generalized-[Formula: see text] method and [Formula: see text]-Bathe method fail, the proposed method shows strong stability and accuracy. Further, for nonlinear problems in which all methods’ results are convergent, the proposed method has greater accuracy, efficiency, and energy-conservation capability.
A Geometrically Exact Beam Finite Element for Non-Prismatic Strip Beams: Linearized Lateral-Torsional Stability
Authors: Gonçalves Rodrigo
Published: December 2022

This paper presents a new geometrically exact beam finite element able to perform, accurately and efficiently, linear stability analyses of curved and tapered elastic strip beams (beams with thin rectangular cross-section) susceptible to lateral-torsional bucking. This element constitutes a non-trivial extension, to the spatial (3D) case, of that previously reported by the author for the in-plane (2D) case in Gonçalves [R. Gonçalves, A geometrically exact beam finite element for non-prismatic strip beams: The 2D case, Int. J. Struct. Stab. Dyn. (2022) 2350037]. To allow capturing accurately torsion effects, a torsion-related warping function is derived and included as an additional cross-section degree-of-freedom (DOF). Since the element is developed using a geometrically exact framework, complex effects such as load height and out-of-plane flexural-torsional effects are straightforwardly included. For implementation purposes, all fundamental expressions are provided in simple vector/matrix forms. A set of numerical examples is presented and discussed, to show that the proposed element provides very accurate solutions with a small DOF number, even for heavily curved and tapered members.
A characterization of Goldie extending trivial Morita contexts
Authors: Moradiani Sara , Moussavi Ahmad , Zahiri Masoome
Published: December 2022

A module [Formula: see text] is said to be extending (Goldie extending) if for each submodule [Formula: see text] there exists a direct summand [Formula: see text] of [Formula: see text] such that [Formula: see text] is essential in [Formula: see text] (if for every submodule [Formula: see text] of [Formula: see text] there exists a direct summand [Formula: see text] of [Formula: see text] such that [Formula: see text] is essential in both [Formula: see text] and [Formula: see text]). In this paper, a necessary and sufficient condition is obtained for a trivial Morita context ring to be right Goldie-extending.
A High-Throughput, Resource-Efficient Implementation of the RoCEv2 Remote DMA Protocol and its Application
Authors: Schelten Niklas , Steinert Fritjof , Knapheide Justin , Schulte Anton , Stabernack Benno
Published: December 2022

The use of application-specific accelerators in data centers has been the state of the art for at least a decade, starting with the availability of General Purpose GPUs achieving higher performance either overall or per watt. In most cases, these accelerators are coupled via PCIe interfaces to the corresponding hosts, which leads to disadvantages in interoperability, scalability and power consumption. As a viable alternative to PCIe-attached FPGA accelerators this paper proposes standalone FPGAs as
Network-attached Accelerators (NAAs)
. To enable reliable communication for decoupled FPGAs we present an
RDMA over Converged Ethernet v2 (RoCEv2)
communication stack for high-speed and low-latency data transfer integrated into a hardware framework.

For NAAs to be used instead of PCIe coupled FPGAs the framework must provide similar throughput and latency with low resource usage. We show that our RoCEv2 stack is capable of achieving 100 Gb/s throughput with latencies of less than 4μs while using about 10% of the available resources on a mid-range FPGA. To evaluate the energy efficiency of our NAA architecture, we built a demonstrator with 8 NAAs for machine learning based image classification. Based on our measurements, network-attached FPGAs are a great alternative to the more energy-demanding PCIe-attached FPGA accelerators.
Blockchain-Based Privacy Preservation for IoT-Enabled Healthcare System
Authors: Sharma Pratima , Namasudra Suyel , Chilamkurti Naveen , Kim Byung-Gyu , Gonzalez Crespo Ruben
Published: December 2022

Blockchain technology provides a secure and reliable platform for managing data in various application areas, such as supply chain management, multimedia, financial sector, food sector,Internet of Things (IoT), healthcare, and many more. The recent emergence of blockchain with IoT provides significant growth in the healthcare industry to improve security, privacy, efficiency, and transparency with more business opportunities. Nevertheless, conventional healthcare schemes suffer from various security attacks like collusion, phishing, masquerade, etc. Therefore, a privacy-preservingDistributed Application (DA)is proposed in this paper using blockchain technology to create and maintain healthcare certificates. Here, the distributed application provides an interface between the blockchain network and system objects like healthcare centers, verifiers, and regular authorities to generate and issue medical documents. In addition, it also ensures security by specifying rules using various smart contracts. To evaluate the performance of the proposed scheme, various experimental tests are conducted using the Etherscan tool for measuring operation cost, latency, and processing time. Here, the efficiency of the proposed system is also compared to the existing systems in terms of latency, throughput, and response time. The experimental results and comparative analysis show that the proposed work is more efficient than the existing techniques.
Transcription factor HNF1β controls a transcriptional network regulating kidney cell structure and tight junction integrity
Authors: Tholen Lotte E. , Latta Femke , Martens Joost H. A. , Hoenderop Joost G. J. , de Baaij Jeroen H. F.
Published: December 2022

Genetic defects in transcription factor hepatocyte nuclear factor (HNF)1β cause a heterogeneous disease characterized by electrolyte disturbances, kidney cysts, and diabetes. By combining RNA-sequencing and HNF1β chromatin immunoprecipitation-sequencing data, we identified new HNF1β targets that were enriched for cell polarity pathways. Newly discovered targets included members of polarity complexes Crb3, Pard6b, and Llgl2. Functional assays in kidney epithelial cells demonstrated decreased tight junction integrity and a loss of typical cuboidal morphology in mutant Hnf1b cells.
WT1 regulates expression of DNA repair gene Neil3 during nephrogenesis
Authors: Dickinson Kyle , Hammond Leah , Akpa Murielle , Chu Lee Lee , Lalonde Caleb Tse , Goumba Alexandre , Goodyer Paul
Published: December 2022

We studied the molecular events leading to Wilms tumors as a model for the repair of genomic injury. Specifically, we showed that WT1 activates DNA repair gene Neil3 in nephron progenitor cells. However, our observations offer a much broader principle, demonstrating that the embryonic kidney invests in lineage-specific expression of DNA repair enzymes. Thus, it is conceivable that failure of these mechanisms could lead to a variety of “sporadic” congenital renal malformations and human disease.
Turning lung clearance index on its head. Reference data for SF6 multiple-breath washout derived ventilation distribution efficiency
Authors: Sandvik Rikke Mulvad , Lindblad Anders , Robinson Paul D. , Nielsen Kim G. , Gustafsson Per
Published: December 2022

Lung clearance index (LCI) is the most used outcome from the multiple-breath washout test. As known for decades, the LCI is not linearly related to dead space ventilation, giving difficulties interpreting changes over time and in clinical trials. We present a new and improved outcome based on LCI, the ventilation distribution efficiency (VDE), which solves this problem by being linearly related to dead space ventilation. A pediatric age range reference equation for VDE is presented.
XPO1-Mediated EIF1AX Cytoplasmic Relocation Promotes Tumor Migration and Invasion in Endometrial Carcinoma
Authors: Ye Yuhong , Lv Chengyu , Sun Jiandong , Lin Zihang , Liu Yue , Huang Yuxiu , Chen Yupeng , Li Hua , Lian Xiuli , Jiang Xia , Zhang Sheng , Wang Shie
Published: December 2022

Dysregulation of eukaryotic translation initiation factor 1A, X-linked (EIF1AX), has been implicated in the pathogenesis of some cancers. However, the role of EIF1AX in endometrial carcinoma (EC) remains unknown. We investigated the EIF1AX expression in EC patients and assessed its tumorigenesis-associated function and nucleocytoplasmic transport mechanism in vitro and in vivo. The results indicated that the cytoplasmic EIF1AX expression showed a gradual increase when going from endometrium normal tissue, simple endometrial hyperplasia, complex endometrial hyperplasia, and endometrial atypical hyperplasia to EC, while vice versa for the nuclear EIF1AX expression. In addition, the cytoplasmic EIF1AX expression was positively correlated with histologic type, high International Federation of Gynecology and Obstetrics (FIGO) grade, advanced FIGO stage, deeper infiltration, high Ki67 index, and shorter recurrence-free survival in EC patients. In vitro, short hairpin RNA-mediated EIF1AX depletion or SV40NLS-mediated EIF1AX import into the nucleus in multiple human EC cells potently suppressed cell migration and invasion, epithelial-mesenchymal transition, and lung metastasis. Moreover, exportin 1 induced the transport of EIF1AX from the nucleus to the cytoplasm that could be inhibited by leptomycin B treatment or the mutation in the EIF1AX location sequence. These results demonstrate that cytoplasmic EIF1AX may play a key role in the incidence and promotion of EC, and thus, targeting EIF1AX or its nucleocytoplasmic transport process may offer an effective new therapeutic approach to EC.
A Covariance Matrix-Based Cooperative Spectrum Sensing Algorithm in Electric Wireless Private Network
Authors: Zhao Xu , Gan Jie , Xu Weiyang , Huang Tiancong
Published: December 2022

Cognitive radios can significantly improve the spectral efficiency of wireless communications. Spectrum sensing is a key function of cognitive radios to prevent the harmful interference with licensed users. This paper considers the cooperative spectrum sensing in 230 MHz electric wireless private networks. First, the statistical distribution of the sample covariance matrix of the received signals is investigated. Then, taking the ratio of the sum of absolute values of the off-diagonal elements of the sample covariance matrix to that of the diagonal elements as the decision metric, an improved covariance absolute value (ICAV) cooperative sensing algorithm is proposed. After that, a performance analysis concerning the probabilities of false alarm and detection is carried out. Theoretical analysis and simulation results show that the ICAV algorithm possesses an accurate decision threshold and is robust to the noise uncertainty.
Anemia, Thrombocytopenia, and Changes in Biochemical Parameters Occurring in Patients with Uncomplicated Plasmodium falciparum Malaria: Data Analysis from Antimalarial Efficacy-Randomized Trials in Dakar and Kaolack Regions, Senegal
Authors: Sylla Khadime , Tine Roger , Sow Doudou , Lelo Souleye , Abiola Annie , NDiaye Jean Louis , NDiaye Magatte , Folly Kuaku , NDiaye Léon Amath , Gaye Oumar , Faye Babacar
Published: December 2022

Background. Artemisinin-based Combination Therapies (ACTs) are widely used in the treatment of uncomplicated malaria. Plasmodium falciparum infection is often accompanied by disturbances of hematological and biochemical parameters. The objective of this study was to evaluate the changes in biochemical and hematological parameters during uncomplicated malaria in patients treated with ACTs. Methods. Data from patient with uncomplicated Plasmodium falciparum malaria were pooled from different open-randomized trial evaluating the efficacy of Artesunate-Mefloquine (ASMQ), Artesunate-Amodiaquine (ASAQ), Artemether-Lumefantrine (AL), and Dihydro-artemisinin-Piperaquine (DHAPQ) combinations. Biochemical (transaminases, creatinine, and bilirubin) and hematological (hemoglobin and platelet levels) parameters were performed at baseline (D0) and at day 7 after treatment (D7). Data were analyzed as both continuous and categorical variables with 95% confidence interval. Risks and trends were calculated using multivariate logistic random effect models. Results. A total of 720 patients with completed biological data were included in the analysis (320 in the AL arm, 160 in the ASMQ arm, 120 in the DHAPQ arm, and 88 in the ASAQ arm). The mean age of the patients was

9.43
±
9.1

years. Male subjects represented 58.47% (sex ratio was 1.4 for males). The mean hemoglobin level at inclusion (D0) was 9.79 g/dl and anemia (

Hb
<
11
 
g
/
dl

) was 71.43% (

aOR
=
1.16
 

0.68
−
1.98

p
=
0.57

). At D7, hemoglobin level was 9.63 g/dl and anemia was significantly more frequent (78.29% [

p
=
0.002

]). The mean platelet count at day 0 was 154075.5 platelets/mm3 of blood and 339328.7 platelets/mm3 at day 7. Thrombocytopenia was about 53.61% and was associated with malaria (

aOR
=
3.4
 

2.18
−
5.3

p
<

10

−
3

). 19.58% of patients had abnormal ALT and 40.28% had abnormal AST at D0. 27.22% of patients had normal bilirubin at D0. Renal function was normal in all patients in the study. Normalization of transaminases was noted between D0 and D7. The percentage of subjects with normal bilirubin increased between D0 and D7. Renal function did not vary significantly between D0 and D7. Conclusion. Results from this analysis showed that subjects with high parasitaemia had a greater risk of anemia and thrombocytopenia. Artemisinin combinations were well-tolerated as no major biological disturbances were noted. The effects of ACTs on hematologic and biochemical parameters were not different.
Robust Keypoint Detection and Matching on Fisheye Images by Self-Supervised Learning
Authors: Tian Wei , Cai Pei , Wen Yongkun , Chu Xinning
Published: December 2022

Accurate image feature point detection and matching are essential to computer vision tasks such as panoramic image stitching and 3D reconstruction. However, ordinary feature point approaches cannot be directly applied to fisheye images due to their large distortion, which makes the ordinary camera model unable to adapt. To address such a problem, this paper proposes a self-supervised learning method for feature point detection and matching on fisheye images. This method utilizes a Siamese network to automatically learn the correspondence of feature points across transformed image pairs to avoid high annotation costs. Due to the scarcity of the fisheye image dataset, a two-stage viewpoint transform pipeline is also adopted for image augmentation to increase the data variety. Furthermore, this method adopts both deformable convolution and contrastive learning loss to improve the feature extraction and description of distorted image regions. Compared with traditional feature point detectors and matchers, this method has been demonstrated with superior performance on fisheye images.
Development and Resolution of Secondary Adrenal Insufficiency after an Intra-Articular Steroid Injection
Authors: Tan Jia Wei , Majumdar Sachin K.
Published: December 2022

Corticosteroid injections are commonly indicated in inflammatory conditions involving the soft tissues, tendon sheaths, bursae, and joints. Local corticosteroids carry a lower risk of complications than systemic corticosteroid but may be systemically absorbed and subsequently suppress the hypothalamic-pituitary-adrenal (HPA) axis. This can cause secondary adrenal insufficiency (SAI) as well as iatrogenic Cushing’s syndrome. We report a 78-year-old female who presented with nonspecific gastrointestinal symptoms after a recent intra-articular steroid injection in her shoulder. She had hyponatremia, low morning cortisol, and failed to respond to high-dose cosyntropin. Further workup revealed the underlying cause to be SAI. Follow-up testing revealed a recovery of HPA responsiveness within 2 weeks of her initial diagnosis. Conclusion. Our case highlights how the hypothalamic-pituitary axis (HPA) can be suppressed with intra-articular steroids. The threshold to test corticosteroid users for adrenal insufficiency should be low in clinical practice, especially for those patients with nonspecific symptoms after steroid injections. Once diagnosed, temporary treatment with steroids may be required.
BYPASS-OMA: Hypoglycemic Hyperinsulinemic Nesidioblastosis after Gastric Bypass Surgery—A Case Report and Review of the Literature
Authors: Cao Jessica , Kim Cindy , Huynh Thatcher , Frugoli Amanda , Henson Heidi , Valdez Vera , Westhoff-Pankratz Tricia
Published: December 2022

This rare case vignette describes hypoglycemic, hyperinsulinemic nesidioblastosis in a female patient with prior Roux-en-Y gastric bypass. The patient presented with severe symptomatic hypoglycemia resistant to IV dextrose and diazoxide, requiring surgical resection. Traditional imaging found nonspecific findings, and biochemical analysis was inconsistent with insulinoma. A gallium-68 dotatate PET scan was utilized to successfully localize the tumor in the distal pancreas. She underwent laparoscopic resection of the distal pancreatic lesion with resolution of her symptoms and return to euglycemia. The histological evaluation confirmed the diagnosis of nesidioblastosis. Nesidioblastosis is a rare complication of bariatric surgery that may be more clinically relevant with rising prevalence of obesity. Diagnosis with conventional imaging modalities may be challenging; however, the dotatate PET scan may have high utility in detecting lesions. It is essential for clinicians to consider nesidioblastosis in the differential diagnosis of hyperinsulinemic hypoglycemic conditions and recognize there may be a link with increasing rates of bariatric surgery.
The Two-Echelon Vehicle Routing Problem with Transshipment Nodes and Occasional Drivers: Formulation and Adaptive Large Neighborhood Search Heuristic
Authors: Yu Vincent F. , Nguyen Minh P. K. , Putra Kuza , Gunawan Aldy , Dharma I Gusti Bagus Budi
Published: December 2022

This research introduces a new variant of the two-echelon vehicle routing problem (2EVRP) called the two-echelon vehicle routing problem with transshipment nodes and occasional drivers (2EVRP-TN-OD). In addition to city freighters in the second-echelon network, a set of occasional drivers (ODs) is available to serve customers. ODs are the basis of a crowd-shipping system in which crowds with planned trips are willing to take detours to deliver packages in exchange for some compensation. To serve customers, ODs collect the assigned packages at either satellite served by first-echelon trucks or transshipment nodes served by city freighters. We formulate this problem as a mixed-integer nonlinear programming model and develop an adaptive large neighborhood search (ALNS) to solve it. New problem-specific destroy and repair operators and a tailored local search procedure are embedded into ALNS to deal with the problem’s unique characteristics. The experiments show that the proposed ALNS effectively solves 2EVRP-TN-OD by outperforming Gurobi in terms of both solution quality and computational time. Moreover, the experiments confirm that employing occasional drivers leads to lower operational costs. Sensitivity analyses on the characteristics of occasional drivers and the impact of transshipment nodes are presented as interesting managerial insights from 2EVRP-TN-OD.
Identification of ZDHHC1 as a Pyroptosis Inducer and Potential Target in the Establishment of Pyroptosis-Related Signature in Localized Prostate Cancer
Authors: Luo Cheng-Gong , Gui Cheng-Peng , Huang Gao-Wei , Chen Jin-Long , Li Jia-Ying , Li Peng-Ju , Xu Quan-Hui , Wang Ying-Han , Zhu Jiang-Quan , Liang Hui , Wang Zhu , Deng Qiong , Cao Jia-Zheng , Luo Jun-Hang , Lu Jun , Chen Wei
Published: December 2022

Pyroptosis or cellular inflammatory necrosis is a programmed cell death kind. Accumulating evidence shows that pyroptosis plays a crucial role in the invasion, metastasis, and proliferation of tumor cells, thus affecting the prognosis of tumors and therapeutic effects. Prostate cancer (PCa), a common malignancy among men, is associated with inflammation. Pathophysiological effects of pyroptosis on tumor development and progression, as well as the mediation of PCa, are known, but its effects on the potential prognosis for PCa warrant in-depth investigation. Herein, we built a risk model of six pyroptosis-related genes and verified their predictive abilities for prognostic and therapeutic effects. Higher risk scores indicated a higher probability of biochemical recurrence (BCR), higher immune infiltration, and worsened clinicopathological features. To derive scientific and reliable predictions for BCR in patients having PCa, the findings of the current study were verified in the Gene Expression Omnibus (GEO) cohort following evaluation in The Cancer Genome Atlas (TCGA) dataset. Additionally, after evaluating the six genes in the model, ZDHHC1 was found to be an important component. Its antitumor role was further assessed through in vivo and in vitro experiments, and its promoting effect on pyroptosis was further evaluated and verified. The above results provided a new perspective for further studies on pyroptosis and its clinical utility for PCa.
Overlapping Community Detection Based on Strong Tie Detection and Non-Overlapping Link Clustering
Authors: Guo Lin , Zhang Miao
Published: December 2022

Many clustering algorithms are in favour of node-based methods, but a link between nodes has one single feature, so link-based clustering is sometimes easier than node-based methods. Being dependent on the characteristics of links, a detection algorithm for a non-overlapping link community is put forward in this paper. The method proposed also distinguishes the differences between nodes with a high degree of accuracy and detects communities with a minimal number of overlapping nodes. On the basis of three different datasets, experiments were conducted to compare the proposed algorithm with different non-overlapping and overlapping clustering algorithms, and the results show that our algorithm generates the least number of overlapping nodes and achieves a good community partition.
Dynamical Property of the Shift Map under Group Action
Authors: Ji Zhanjinag
Published: December 2022

Firstly, we introduced the concept of

G
‐

Lipschitz tracking property,

G
‐

asymptotic average tracking property, and

G
‐

periodic tracking property. Secondly, we studied their dynamical properties and topological structure and obtained the following conclusions: (1) let

X
,
d

be compact metric

G
‐

space and the metric

d

be invariant to

G

. Then,

σ

has

G
¯

‐

asymptotic average tracking property; (2) let

X
,
d

be compact metric

G
‐

space and the metric

d

be invariant to

G

. Then,

σ

has

G
¯

‐

Lipschitz tracking property; (3) let

X
,
d

be compact metric

G
‐

space and the metric

d

be invariant to

G

. Then,

σ

has

G
¯

‐

periodic tracking property. The above results make up for the lack of theory of

G
‐

Lipschitz tracking property,

G
‐

asymptotic average tracking property, and

G
‐

periodic tracking property in infinite product space under group action.
Evaluation of Rock Burst Propensity and Rock Burst Mechanism in Deep Phosphate Mines: A Case Study of Sujiapo Phosphate Mine, Hubei Province, China
Authors: Kang Qinrong , Xia Yuandi , Shi Minghan , Zhang Weizhong , Wang Weiqing , Kong Dehua , Wang Yunpeng
Published: December 2022

Rockburst is one of the major problems in rock underground engineering and mechanics. To make a risk assessment of rockburst and improve the mine safety index, some evaluation systems for rockburst propensity have been proposed and applied, and progress has been made in the study of high-value mines and single evaluation systems, but these evaluation systems are still immature for deep low and medium grade phosphate mines with more complex influencing factors. Therefore, to solve this problem, this study takes the phosphate mining area of the Sujiapo phosphate mine as the main research object, and combines the characteristics of the deep rockburst of the phosphate mine and its physical and mechanical properties; the evaluation system combines fuzzy mathematical method and multiple evaluation methods to determine the propensity of rockburst of deep mining of Sujiapo phosphate mine. The JSM-500LV SEM and acoustic emission results are used to analyze the microscopic mechanism of rockburst from the morphology and composition of the rocks, and the rationality of the evaluation system is further demonstrated. The study shows that dolomite and phosphorite in the study area are moderate rockburst, and shale has a weak rockburst tendency; because the roof dolomite and phosphorite crystallization degree are higher, the elastic modulus is large. Under the action of external load, the roof dolomite stored more elastic strain energy. Deformation damage consumes less energy. The energy released to the outside world after the damage is large, more likely to occur brittle damage, and the rockburst tendency is high. Therefore, the evaluation system combining multiple evaluation methods can comprehensively determine rockburst in phosphate mines.
An Intelligent System for Cucumber Leaf Disease Diagnosis Based on the Tuned Convolutional Neural Network Algorithm
Authors: Omer Saman M. , Ghafoor Kayhan Z. , Askar Shavan K.
Published: December 2022

In agriculture farming, pests and other plant diseases are the most imperative factor that causes significant hindrance to cucumber production and its quality. Farmers around the globe are currently facing difficulty in recognizing various cucumber leaf diseases, which is imperative to preventing leaf diseases effectively. Manual techniques to diagnose cucumber diseases are often time-consuming, subjective, and laborious. To address this issue, this paper proposes a tuned convolutional neural network (CNN) algorithm to recognise five cucumber diseases and healthy leaves that comprises image enhancement, feature extraction, and classification. Data augmentation methods were utilized as a preprocessing step to enlarge the datasets, and it was also to decrease the chance of overfitting. Automatically features are extracted by using CNN layers. Finally, five cucumber leaf diseases and one healthy leaf are classified. Furthermore, to overcome the lack of a public dataset, a new dataset of cucumber leaf diseases has been constructed that includes spider, leaf miner, downy mildew, powdery mildew, one viral disease, and healthy class leaves. The dataset has a total of 4868 cucumber leaf images. In order to prove the authenticity of the proposed CNN, comparative experiments were conducted using pretrained models (AlexNet, Inception-V3, and ResNet-50). The proposed CNN achieves a recognition accuracy of 98.19% with the augmented dataset and 100% with the publicly plant disease dataset. The experimental results confirm that the proposed CNN algorithm was efficient for recognizing the cucumber leaf diseases compared with other algorithms.