bluuebunny/crossref_metadata_2025 huggingface dataset:
Heterogeneity of Grid Emission Factor Accounting in China: Temporal Resolution, Spatial Resolution, and Energy Distribution
Authors: Dong Hongchuan , Gu Ye , Zhang Jihong
Published: October 2024

Grid emission factor has become the most critical variable in carbon market quota allocation and carbon footprint accounting of international trade products. Different grid emission factors will lead to great differences in carbon emissions of enterprises or products. It is found that the temporal resolution, spatial resolution and energy distribution of cogeneration have great influence on the emission factors of power grid. This paper uses the data of China’s power industry to carry out empirical analysis. For each dimension, we set different choices and explore their specific impacts. It is found that the different choices of the three dimensions will cause 5.01%, 20.59%, 4.38% differences in the calculation results of grid emission factors. Finally, based on the research results, this paper puts forward suggestions from three aspects: authoritative guidance, data accuracy and international communication, in order to provide reference for Scope 2 greenhouse gas emissions accounting and reporting.
Research on Carbon Emission Pathways and Scenario Models in the Building Sector
Authors: Liu Yun , Pan Xing , Wang Mengqi
Published: October 2024

Energy conservation and emission reduction constitute pivotal measures for advancing China’s high-quality development. Since 2020, the “Dual Carbon” initiative, encompassing carbon peaking and carbon neutrality, has emerged as a cornerstone of China’s national strategy. Carbon emissions throughout the lifecycle of buildings in the building sector exceed half of all energy-related carbon emissions. Understanding and managing carbon emission pathways and patterns, particularly in the context of energy-efficient green buildings, stands as a critical imperative within the current building industry. This study employs various scenario models to calculate and analyze the potential benefits of promoting green building applications under different scenarios. It also investigates how energy conservation primarily contributes to reducing carbon emissions.
Reducing Methane Emissions in Ruminant Production: Methods and Their Impacts
Authors: Zhang Zifang
Published: October 2024

Introduction: Greenhouse gases contribute significantly to the greenhouse effect, with methane being one of the primary gases. Methane emissions largely stem from ruminant production. Reducing methane emissions from ruminants is beneficial for the environment and improves the feed efficiency of the animals. This article examines the process by which cattle produce methane in the rumen through enteric fermentation and how this methane is subsequently released into the atmosphere. Additionally, various methods to mitigate methane emissions from ruminants are summarized. Main text and discussion: Several methods to address methane emissions from cattle were discussed. First, feed additives: Adding certain compounds or biological extracts to cattle feed can significantly reduce methane emissions. Second, efficient feeding management: Intensive management strategies, such as feeding cattle at specific times, can minimize energy loss and improve feed efficiency. Third, genetic methods: Genomic selection can be used to select animals with lower methane emissions, and gene editing tools can be employed to modify the genes of cattle. Breeding varieties that produce less methane, such as miniature cows, were also considered. The advantages and disadvantages of each biological solution were summarized. Furthermore, political and economic strategies that could potentially replace conventional beef were explored. Conclusion: The greenhouse effect caused by greenhouse gases presents a major challenge that requires a multifaceted approach. Genetic engineering, including gene editing, shows promise but is still developing. Feed additives can reduce ruminant methane emissions, while legislative measures can improve economic structures. Cultured or alternative meats can serve as substitutes for ruminant meat. Although each method has limitations, combining them may yield the best results.
Group decision-making with hesitant fuzzy linguistic preference relations in view of worst and average indexes
Authors: Li Jian , Xiang Yuanyuan , Niu Li-li , Chen Qiongxia , Ye Jianping , Wu Guang
Published: October 2024

To address the multi-criteria group decision-making (MCGDM) problems with hesitant fuzzy linguistic preference relations (HFLPRs), this study introduces a group decision-making (GDM) method in view of worst additive consistency index (WACI) and average additive consistency index (AACI) simultaneously. First, several optimization models are constructed for deriving the WACI and AACI. The main characteristic of the constructed models is that it takes into accounted the personalized individual semantics (PISs). Based on this, the concept of acceptable additive consistent HFLPRs is developed. Second, to improve the consistency of HFLPRs, several optimization models are constructed. Two predefined thresholds for the WACI and AACI are considered in the proposed models. It requires the consistency levels of all the linguistic preference relations (LPRs) associated with an HFLPR meets the threshold of WACI, and the average consistency level of all LPRs reaches the threshold of AACI. Third, an algorithm is designed for deriving priority weights from acceptable consistent HFLPRs. Finally, the presented models are validated for 3D visualization management system selection problem and extensive comparative analyses.
English language assessment practices in Chinese universities: A critical examination of testing methods and their implications for student learning
Authors: Zhang Xinyue
Published: October 2024

English, as an essential skill for cross-cultural communication, underpins China’s globalization efforts. Currently, English assessment methods in Chinese universities primarily rely on traditional paper-and-pencil tests and standardized examinations. While these methods are effective in evaluating vocabulary, grammar, and reading skills, they fall short in assessing practical skills such as listening and speaking. This paper examines the current state and challenges of English language assessment in Chinese universities, highlighting its limitations and proposing improvements. The study finds that the current assessment system places excessive emphasis on test scores and neglects practical language application abilities. Through a literature review, this paper identifies existing problems in university English teaching, discusses the feasibility of diversifying assessment forms, increases the weight of listening and speaking tests, and suggests innovative evaluation methods. The paper also recommends learning from advanced foreign language assessment practices, enhancing practical tests, and utilizing modern technology for assessments to improve fairness and effectiveness, thereby promoting the comprehensive development of students’ language abilities.
The problem of international class solidification in the post pandemic era -- An analysis based on Marxist theory
Authors: Wang Yuao
Published: October 2024

Since the outbreak of COVID-19, the pandemic has significantly impacted the global economy and deeply affected social structures and class mobility. It has exacerbated income inequality, employment difficulties, and unequal distribution of social resources, leading to more pronounced social stratification. In China, despite government economic stimulus policies, small and medium-sized enterprises and the service industry have faced severe challenges, resulting in significant unemployment and income reduction among low-income workers. The rise of platform capitalism has introduced new labor relations, raising concerns about labor rights. This study uses a Marxist perspective to analyze post-pandemic social stratification in China, focusing on economic resource distribution, access to educational resources, and the effectiveness of social policies. The objective is to understand the structural causes and propose policy recommendations to promote social equity and mobility.
Research on the Development Path of Realizing Internationalization of Education
Authors: Gao Yirui
Published: October 2024

With the development of society, the issue of internationalization of education has gradually attracted people's attention. Economic globalization has increased exchanges between different countries, and the development of the Internet has made more people know about the internationalization of education. Both of these have brought new opportunities to the internationalization of education. While broadening personal horizons, it has also increased communication between countries. However, there are still problems in the development process of internationalization of education. This article analyzes the development path of educational internationalization and finds that there are regional, economic, and cultural background issues in educational internationalization through research on the current situation. Based on this, this article proposes the following suggestions: provide support to poverty-stricken areas and narrow the gap between regions. At the same time, if necessary, provide some economic assistance to students participating in the internationalization of education. In terms of cultural differences, engage in international communication and spread culture to other countries.
Research on Problems and Countermeasures of Education Rights of Special Children Groups
Authors: Tan Yiqi
Published: October 2024

This article explores the educational rights of children with special needs and the right to education for children with special needs is a crucial component of an inclusive society, advocating for inclusive education as a fundamental right, which delves into the unique psychological, physical, cognitive, and social needs of these children and emphasizes the importance of Individualized Education Programs (IEPs), assistive technologies, and community support. It delves into the unique characteristics and educational priorities of children with special needs, identifies the problems and barriers they face in accessing education, and proposes strategies and recommendations for improvement, it also highlights the progress made in policy and societal attitudes, along with the challenges that remain, particularly in resource-poor areas. Meanwhile, it discusses legal and policy barriers, societal attitudes, and infrastructure issues, proposing policy reform, innovative educational strategies, and increased community and family involvement as solutions. The article concludes by calling for ongoing research and advocacy to ensure that the right to education for children with special needs is fully realized.
An Exploration of the Artistic Image of Female Characters in Chinese Independent Female-Oriented TV Series
Authors: Zhai Zixuan
Published: October 2024

This paper studies the artistic image of female characters in Chinese independent female-themed TV dramas, mainly exploring whether the female characters in such themed TV dramas are diversified and full, whether they have certain values, and whether they are fully embodied in the image of women. Through this analysis, it can be observed that the changes in the social perception and expectation of female characters, and thus understand the trend of social and cultural evolution. Independent female-themed TV dramas often focus on women’s independence and autonomy in family, workplace and society, etc. The study of these character images can reveal the status and role of women in contemporary society. Based on this in-depth exploration by analyzing the three dimensions of role diversity, depth and complexity, and influence, to find the common points and the problems of the current Chinese independent female TV dramas, as well as the root causes of the audience’s praise, criticism, or dismissal of such dramas, which are the demands of the women in their lives for their lives, careers, marriages, personal values, and families. By interpreting the results, it promotes the advancement of Chinese themed TV dramas as well as social concepts.
The use of immersive experiences and digital technology in the preservation of intangible cultural heritage - ‘Dongba’
Authors: Shi Yatong
Published: October 2024

Recently, some precious cultures have been forgotten, ‘Dongba’ as one of the Intangible Cultural Heritages (ICH) is experiencing a disappearance in the modern world. ‘Dongba’ culture includes various elements, such as scripts, graphics, and craftsmanship. To restore the ancient circumstances, scriptures, voices, and movements, to assist the audience in entering the immaterial memorial heritage world, and to explore the civilization of such an ancient tribe culture is the primary purpose of this essay. In this paper, the author attempts to build a conceptual structure of combining digital media and immersive experiences with the ‘Dongba’ and some related cultures. The conceptual design structure will be used in various conditions, for example, education, exhibition, tourism, advertisement, and more commercial purposes. Immersive experiences based on digital technology are a growing trend in the contemporary world. There is a design project for an immersive experience using 3D (Three-dimensional) sculpt modeling technology, providing a conceptual approach for future design and research. The outcome of this research will be 3D models rendering which represent three different elements of the ‘Dongba’ culture, demonstrating that immersive experiences can be an advanced method for preserving intangible cultural heritages, not only just ‘Dongba’ culture.
Research on audience psychological communication in the era of new media--taking the MBTI phenomenon as an example
Authors: Fan Xiaofei
Published: October 2024

This article adopts a literature analysis method, taking the popular phenomenon of MBTI（Myers Briggs Type Indicator） in the current era of new media as the background, aiming to study the emergence and development process of MBTI from the perspective of audience psychology. The author conducts analytical research on communication psychology-related theories such as usage and satisfaction, selective contact hypothesis, and interest groups, deeply explores the application of MBTI in audience psychology research, analyzes its value in understanding audience behavior and psychological characteristics, and explores its challenges and prospects in practical applications. While MBTI has become popular, it has also brought some negative orientations due to its labeling, such as stereotypes and group anxiety. The fanaticism and initiative exhibited by individuals in the congenial group trigger group effects through communication. In the era of new media, with the rapid development of various media matrices, how to rationally view the emotional interactions of individuals and even groups constructed by MBTI, how to use the power of new media to correctly meet audience needs, and how to make the emergence and dissemination of MBTI conform to the benign trend of social development are all issues worthy of in-depth research.
Change and Development of News Communication in China
Authors: Meng Ziyan
Published: October 2024

This paper discusses the change and development of the field of news dissemination in China, focusing on the far-reaching impact of technological progress, policy adjustments and changes in social demand on news dissemination. With the rapid development of the Internet and mobile communication technology, the form of news dissemination has undergone a fundamental change, gradually shifting from traditional media to new media. This transformation has not only changed the way of information production and dissemination, but also reshaped the audience’s habits of acquiring and consuming information. By systematically analysing these changes and developments, this paper reveals the important impacts of technological advancement drives, policy adjustments and changes in social demands on the development of news dissemination in China, which have promoted the speed and breadth of information dissemination, changed the way of news production, and allowed for increased audience participation, but also intensified media competition. It aims to provide reference for related research and useful insights for news communicators in practice.
Analysis of the current status of children’s mental health
Authors: Tai Yuxin
Published: October 2024

This paper systematically analyzes the current status of the mental health of young children, summarizing both the positive and negative aspects. It explores the underlying causes of these phenomena and proposes corresponding suggestions for improvement. Through a detailed analysis of the literature, the paper highlights how increasing attention and the popularization of mental health education have allowed more children to access mental health knowledge and counselling early on. Despite this progress, challenges persist due to modern lifestyle changes, rapid technological advancements, and urbanization, which negatively impact children’s mental health. Many children suffer from a lack of emotional support, high psychological pressure, and exposure to harmful information within their family and social environments. To address these issues, the paper emphasizes the need for improvements in family environments, societal support, and policies, as well as enhancements to the mental health service system. The recommendations include fostering better parent-child communication, using electronic devices judiciously, and creating supportive home environments. On a broader scale, it calls for stronger policy support, improved mental health services, and widespread mental health education.
The Role of French Revolution Fan Discussions on Tumblr in Shaping Contemporary French Political Discourse
Authors: Ma Jingyang
Published: October 2024

History fandom gathers people who discuss and produce narratives of history. Through media participation, history fandom has risen to attract mainstream attention. Meanwhile, political campaigns on media increasingly converge with fandom mobilization, many of which rely on narrating history to convey their ideas. However, whether and how history fandom has influenced the political discourses on media has not been researched. To explore the potential development of these two domains, this article studied the fan discussions of contemporary politics in the French Revolution fan community on Tumblr. With discourse analysis of the language and power background of history fans’ blogs that are relevant to contemporary French politics, this article demonstrated the capability and limitation of fans’ narratives of history in influencing mainstream politics. Shaped by Tumblr’s platform ecosystem, the fandom has collective political values and bases its history narratives on them to resist the ideologies imposed by existing political structures. Nevertheless, to challenge the structure, history fans need to extend their influence beyond the cultural realm. If political forces and fandom can be further connected by the narration of history, the fans’ immaterial labour can be exposed to mainstream media, allowing fans’ self-emancipatory activities to bring social-political changes.
Deconstructing marketing modes and branding strategies of fast fashion industry: A case study of UNIQLO
Authors: Li Siyi
Published: October 2024

The fast fashion industry is increasingly important for people’s daily lives. For most individuals, buying cheap clothes with fashionable designs and good quality meets their needs. As one of the most famous brands in the world, UNIQLO built a huge business empire with unique marketing modes and branding strategies. In this research, the writer focuses on the comprehensive marketing strategies of UNIQLO, compares the different strategies of different fast fashion companies, and highlights the unique strengths of UNIQLO. The research concludes that UNIQLO is successful because it is inclusive, cheap, and fine, combining innovation and conservation, avant-garde and popular combination. In addition, with the proper use of marketing strategies such as IP co-combining, celebrity and influencer endorsement, promotions, and incentives, UNQILO’s adaptive consumers are all over the world at all ages, allowing a bigger market selling online and offline. It is one of the most all-sided selling modes in the world. Hence, UNIQLO has significant reference value to other brands to promote their brands in the future.
A Review of Research on Factors Influencing Chinese Consumers' Healthy Food Purchases
Authors: Gao Yang
Published: October 2024

The public's health awareness has increased substantially with the progress of society, food safety incidents are frequent, and the Chinese government has introduced a number of health-related policies, so it is necessary to study the influencing factors on consumers' purchasing of healthy food. This paper investigates the influencing factors on consumers’ purchase of healthy food through literature analysis and finds that consumers’ perception of healthy food significantly influences their purchase of healthy food through different dimensions. Perceptions are correlated with education, however, when consumers perceive that the health food market in China is not sufficiently safe and secure the higher their level of concern the lower their purchase rate. Purchasing habits and preferences, income level, type of occupation, and personal and family health conditions all have an impact on the purchase of healthy foods. Among product factors high prices are a major barrier to healthy food purchases. Government regulation of the food industry and consumer protection all have a strong effect on consumer purchases of healthy food. Characteristics such as the environment, convenience, trustworthiness and price level of the place of consumption also have an impact on the purchase of health food.
Digital transformation: A comparative study of the impact of digital fashion shows on traditional fashion shows
Authors: Yu Yuefeng
Published: October 2024

This paper explores the transformative impact of digital fashion shows on the traditional landscape of fashion presentations and the market positioning within the fashion industry. The advent of digital fashion shows introduces new dimensions to the showcase of fashion, challenging conventional concepts of fashion and presentation. This study examines the expression of creativity and craftsmanship by designers in traditional fashion shows, delving into the dynamics of audience interaction and experience, and analyzing business models and brand strategies that are crucial for industry success. The integration of new technologies with digital fashion shows has revolutionized the modalities of fashion presentations and audience engagement, offering innovative ways for a global audience to participate in fashion events. This paper also discusses the potential for market expansion and sustainability within digital fashion shows, emphasizing their role in shaping the future of the industry. A comparative analysis highlights the advantages and limitations of both traditional and digital fashion shows, examining their impacts on the fashion market and cultural landscapes. Furthermore, the paper provides insights into future trends and developments, forecasting the potential convergence of these two formats in driving the evolution of the fashion industry.
Analysis and Optimization Of Recommendation Mechanism and Content Creation in Social Media Platform: A Case Study of TikTok Tourism Short Videos
Authors: Li Zhiyang , Xu Zixuan
Published: October 2024

The influence of the videos on the TikTok platform is gradually increasing. Short video platforms disseminate messages that allow users to learn more about the phenomenon and influence their decisions to some extent. This paper investigates the differences between popular tourism short videos created by personal accounts and those created by official cultural and tourism accounts on the TikTok platform in China. Then, it explores the recommendation mechanism and content creation for this type of videos. The study finds that the recommendation mechanism for tourism short videos on the TikTok platform needs to be optimized to achieve further promotion. In addition, the study discovers that the types of videos users preferred were travel tips and food recommendations. This study serves to help enable tourism short videos to be better pushed to the exact audience and enhance the decision-making impact on the users.
Research on Emotional Communication Strategies of Films on Social Media: A Case Study of The Wandering Earth 2 on the TikTok Platform
Authors: Tang Mengze
Published: October 2024

This paper aims to explore emotional communication strategies for films on social media, with a specific focus on the dissemination of The Wandering Earth 2 on the TikTok platform. By analyzing the promotional content, user interactions, and emotional responses related to The Wandering Earth 2 on TikTok, this study reveals how films can leverage social media platforms to facilitate emotional communication, thereby enhancing audience emotional resonance and engagement. The research indicates that the successful dissemination of films on social media relies not only on the creativity and entertainment value of the content but also on a deep understanding and grasp of users’ emotional needs. This paper provides theoretical support and practical guidance for film marketing, highlighting directions for optimizing future film dissemination strategies.
The Evolution of E-Commerce: From Traditional E-Commerce to Live Streaming Sales
Authors: Chen Zhirui
Published: October 2024

In recent years, the rapid development of internet technology and social media platforms has led to significant transformations in e-commerce. Live streaming sales have gradually become a crucial sales model. This paper systematically analyzes the evolution from traditional e-commerce to live streaming sales, exploring key factors of this emerging model and its impact on consumer behavior. Through case studies, this research reveals how live streaming enhances consumers' purchase intentions and brand loyalty through real-time interaction and emotional connection. The findings indicate that while live streaming demonstrates remarkable short-term sales effectiveness, it also faces market competition, product quality, and service issues. The paper also discusses future trends in live streaming, such as integrating augmented reality (AR) and virtual reality (VR) to create more immersive shopping experiences, and data analytics for personalized marketing. Strategic recommendations are proposed to help businesses excel in a competitive market, including enhancing real-time consumer interaction, maintaining product quality, and building strong brand trust. These insights aim to provide a comprehensive understanding of the dynamic landscape of e-commerce and the pivotal role of live streaming in shaping future consumer trends.
New words and meanings arising from literature in modern Chinese: A case study of English loanwords in Lu Xun's novel Call to Arms
Authors: Yuan Xinrui
Published: October 2024

In the period of the May Fourth New Culture Movement, under the background of the Europeanization of Chinese with Western learning in the East, a large number of loanwords were absorbed into Chinese in this period due to the extensive language contact. The use of loanwords in Lu Xun's representative vernacular novel Call to Arms embodies Lu Xun's vocabulary concept of constructing modern vernacular. This paper focuses on the study of English loanwords in Call to Arms, and classifies them into four categories: pure transliteration, transliteration and free translation, letter words and Japanese borrowing form words. These words mainly involve the fields of science, technology, politics, humanities and society, at the same time, new affixes and word formation have appeared in modern Chinese. After being introduced and transformed into the Chinese language, they have been continuously integrated into the specific meanings in the Chinese cultural background during the development process, and gradually localized, forming a unique Chinese vocabulary form.
A Study on the Nonfiction Writing Features of Wang Zengqi's Works
Authors: Wang Xinyi
Published: October 2024

Wang Zengqi's works often take real life as the background, and show the texture of real life by carefully depicting characters, plots and environments. He does not advocate grand themes or emphasize the publicity of discourse expression, but shows his observation, analysis and thinking about the event itself with a clear subjective intervention posture. This paper studies the characteristics of non-fiction writing in Wang Zengqi's novels and prose works, and discusses his interaction with non-fiction regional literature in his works, including the influence of region on him and his writing of the region. It also tells the aesthetic implication of Wang Zengqi's non-fiction writing from three aspects: characterization, narrative and stylistic language, as well as his inheritance of China's traditional non-fiction literature in expression and thought. According to these non-fiction writing characteristics, people can find that Wang Zengqi's works have unique literary and aesthetic values, and have a far-reaching impact on modern literature in China.
Urban Fictional History: Postmodern Space-Time Experimentation in The Atlas by Kai-cheung Dung
Authors: Li Xinhang
Published: October 2024

The critical examination of Hong Kong’s identity and the spatial turn in narrative forms were two prominent characteristics of Hong Kong literature in the late 20th century. Kai-cheung Dung’s novel The Atlas: Archaeology of an Imaginary City, published in 1997, the year of Hong Kong’s handover, addresses this issue, embodying the pursuit and deconstruction of Hong Kong’s local consciousness. This paper focuses on the postmodern features of this work from the dimensions of time and space, including: (1) the dialectical relationship between time and space; (2) the construction of the third space; (3) the latent text of Hong Kong identity. Kai-cheung Dung tries to create an imaginary space that opposes the forgotten and subverted Hong Kong of reality. It is an infinitely expanding literary universe, in which he explores the city's complex nature and pursues a sense of self-orientation born between forgetting and remembering. Through a detailed analysis of The Atlas: Archaeology of an Imaginary City, the opening work of Kai-cheung Dung’s Series of V City, this paper aims to complete the understanding of his continually evolving literary world—revealing a stable internal unity beneath the fragmented and disjointed textual representations.
Ernährung bei nicht immunologisch bedingten Nahrungsmittelunverträglichkeiten
Authors: Römmele Petra
Published: October 2024

Nahrungsmittelunverträglichkeiten werden bei über 15 % der Erwachsenen der westlichen Bevölkerung beschrieben. Nicht selten führen sie zu einseitigem ungünstigen Ernährungsverhalten. Der Beitrag beschäftigt sich mit Ursachen und Ernährungsaspekten von nicht immunologischen Unverträglichkeiten auf Laktose, Fruktose und ausgewählten Pseudoallergien. Die Ernährungstherapie bei Nahrungsmittelunverträglichkeiten berücksichtigt die Einschränkung der Zufuhr des auslösenden Stoffes. Eine vollständige Karenz ist jedoch meist nicht nötig, um eine vollwertige Ernährung bei Symptomfreiheit und bestmöglicher Lebensqualität zu ermöglichen.
Magnesium im Leistungssport
Authors: Kisters Lukas , Gröber Uwe , Kisters Klaus
Published: October 2024

Im Leistungssport spielt das Elektrolyt Magnesium eine sehr wichtige Rolle.
Bekanntermaßen ist eine erfolgreiche sportliche Performance nur dann möglich,
wenn eine gute Magnesiumzufuhr bereits vor einem Wettkampf längerfristig
besteht, und es darf auf gar keinen Fall ein Magnesiumdefizit vorliegen.
Wissenschaftliche Publikationen der letzten Jahre zeigen eine inverse
Korrelation eines Magnesiummangels mit Laktatwerten. Besonders dynamische und
alle Ausdauersportarten erfordern eine gute Magnesiumversorgung. In zahlreichen
sportmedizinischen Studien sind bereits Berechnungen zum individuellen
Magnesiumverlust und Bedarf veröffentlicht worden. Eine Magnesiumsupplementation
ist kein Doping, aber für eine gute Leistung im Leistungssport unerlässlich.
Wirksamkeit eines Balsams aus Cistus und Rosmarin bei Schlafstörungen und anderen somatischen Beschwerden – eine Anwendungsbeobachtung
Authors: Engelbert Christian W.
Published: October 2024

An 125 Probanden wurde die Wirksamkeit einer neuen Zusammensetzung mit Extrakten aus Cistus incanus L. Pandalis und Salvia rosmarinus (Rosmarin) in einem Balsam auf Schlafstörungen, Herz-Kreislauf-Beschwerden, Verdauungsstörungen und Atembeschwerden geprüft. Bei der Selbstanwendung wurde der Balsam auf bestimmte aus der Reflexzonenlehre etablierte Hautzonen aufgetragen und die Effekte wurden mittels Fragebogen ermittelt. Die Ergebnisse zeigten eine positive Wirkung auf unterschiedliche Schlafstörungen. Subjektiv empfundene Herzbeschwerden, erhöhter Blutdruck, Verdauungsstörungen und unspezifische Atemstörungen konnten ebenfalls positiv beeinflusst werden. Der Lefteria Bio Balsam stellt eine Bereicherung in der begleitenden Selbstbehandlung von Schlafstörungen sowie verschiedener somatischer Beschwerden dar. Die Ergebnisse der Anwendungsbeobachtung sollten durch Studien mit klinischer Datenerfassung untermauert werden.
Aescin Inhibits Herpes simplex Virus Type 1 Induced Membrane Fusion
Authors: Ulrich Diana , Hensel Andreas , Classen Nica , Hafezi Wali , Sendker Jandirk , Kühn Joachim
Published: October 2024

Infections with Herpes simplex virus can cause severe ocular diseases and encephalitis. The present study aimed to investigate potential inhibitors of fusion between HSV-1 and the cellular membrane of the host cell. Fusion and entry of HSV-1 into the host cell is mimicked by a virus-free eukaryotic cell culture system by co-expression of the HSV-1 glycoproteins gD, gH, gL, and gB in presence of a gD receptor, resulting in excessive membrane fusion and polykaryocyte formation. A microscopic read-out was used for the screening of potential inhibitors, whereas luminometric quantification of cell-cell fusion was used in a reporter fusion assay. HSV-1 gB was tagged at its C-terminus with mCherry to express mCherry-gB in both assay systems for the visualization of the polykaryocyte formation. Reporter protein expression of SEAP was regulated by a Tet-On 3 G system. The saponin mixture aescin was identified as the specific inhibitor (IC50 7.4 µM, CC50
24.3 µM, SI 3.3) of membrane fusion. A plaque reduction assay on Vero cells reduced HSV-1 entry into cells and HSV-1 cell-to-cell spread significantly; 15 µM aescin decreased relative plaque counts to 41%, and 10 µM aescin resulted in a residual plaque size of 11% (HSV-1 17 syn+) and 2% (HSV-1 ANG path). Release of the HSV-1 progeny virus was reduced by one log step in the presence of 15 µM aescin. Virus particle integrity was mainly unaffected. Analytical investigation of aescin by UHPLC-MS revealed aescin IA and -IB and isoaescin IA and -IB as the main compounds with different functional activities. Aescin IA had the lowest IC50, the highest CC50, and an SI of > 4.6.
Perioral Rejuvenation: Lip Lifts, Corner of Mouth Lifts, and Vermillion Advancements
Authors: Perkins Stephen W. , Sturgill R. Luke
Published: October 2024

Perioral rejuvenation is a critical component in the comprehensive approach to the aging face. The perioral region—comprising the lips, philtrum, and areas surrounding the oral commissures—plays a significant role in an individual's perceived age, attractiveness, and emotional expressions. However, the perioral region is often the “forgotten area” and has the potential to undermine the success of otherwise outstanding rejuvenation surgeries. This article will shed light on 40 years of experience in perioral rejuvenation surgery, demonstrating techniques and methodologies that have consistently yielded long-term, reliable results in my practice.
Building bridges – Fostering collaborative education in training dental informaticians.
Authors: Felix Gomez Grace Gomez , Mao Jason Mengjie , Thyvalikakath Thankam P , Li Shuning
Published: October 2024

Background: Dental informatics is an emerging discipline. Although the accreditation agency governing dental education programs asserts the importance of informatics as foundational knowledge, no well-defined dental informatics courses currently exist within the standard predoctoral dental curriculum. There is a nationwide lack of dental informatics academic programs. This training gap is due to a lack of qualified dental informaticians to impart knowledge on dental informatics.
Objectives: This paper aims to introduce a novel conceptual framework for an interdisciplinary dental informatics program in preparing students to become dental informaticians.
Methods: In 2023, we developed a standalone graduate certificate program in dental informatics at Indiana University (IU) School of Dentistry in collaboration with IU Luddy School of Informatics, Computing, and Engineering and IU Fairbanks School of Public Health. Feedback was collected through online surveys to assess course quality from students who took Introduction to Health Information in Dentistry. Feedback was analyzed qualitatively, utilizing a thematic analysis approach. Common responses relevant to dental informatics education were grouped into themes.
Results: Five major themes emerged during our analysis of the students' feedback: foundational knowledge and skills; experiential learning: learning by doing; access to resources and working on clinical information systems; health promotion through team-based learning; and retention of knowledge assessment and application. A conceptual framework was formulated through these themes as a guideline for future program improvement. This interdisciplinary educational program framework showed how students and faculty from various disciplines could collaborate, learn from each other, and bring in expertise from different domains. The collaboration happens in clinical, laboratory, and virtual settings to acquire hands on learning through practice and research projects.
Conclusions: The developed conceptual framework aligned with the interdisciplinary nature of dental informatics. It can potentially be adopted by other interdisciplinary informatics programs in health and non-health care disciplines.
Antimicrobial Effect of Zinc Oxide Nanoparticle Coating on Titanium 6 Aluminum 4 Vanadium (Ti-6Al-4V)-Fixed Orthodontic Retainer Substrate
Authors: Mohammed Shahbaa A. , Nahidh Mohammed , Khalaf Mohammed K. , Marrapodi Maria Maddalena , Cicciù Marco , Minervini Giuseppe
Published: October 2024

Objectives Due to its excellent biocompatibility, superior mechanical qualities, and exceptional corrosion resistance, titanium 6 aluminum 4 vanadium (Ti-6Al-4V) alloy is frequently used for medical and orthodontic purposes as a fixed retainer after active orthodontic treatment. Titanium lacks the antibacterial characteristics and is bioinert, this may influence the usage of such materials in the field of biomedical applications. Bacterial adhesion to the orthodontic retainer surface is a common first step in infection; this is followed by bacterial colonization ending with the formation of a biofilm. Once biofilm forms, it is highly resistant to medicines and the host immune system's defense mechanism, making it difficult to remove the biofilm from orthodontic retainer. This study aimed to test the antimicrobial effect of a zinc oxide (ZnO) nanoparticle coating on Ti-6Al-4V orthodontic retainers.

Materials and Methods ZnO nanoparticles, with a particle size of 10 to 30 nm, were used to coat the alloy using the electrophoretic deposition method. Various parameters and surface characterization tests were employed to obtain an optimized sample. This sample was subjected to the microbial adherence optical density test to examine the adherence of Streptococcus mutans, Lactobacillus acidophilus bacteria, and Candida
albicans.

Results The optimized sample had a 5-mg/L ZnO concentration, applied voltage of 50 V, and a 1-cm distance between electrodes. The ZnO coating significantly reduced microbial adherence compared to uncoated samples, effectively inhibiting bacterial development.

Conclusion Electrophoretic deposition is an efficient and cost-effective technique for coating orthodontic titanium retainer substrates. Coating Ti-6Al-4V with ZnO nanoparticles increased the antimicrobial effectiveness of the material and as the concentration of the nanoparticles rises, the antimicrobial effect increases too.
Optimizing Decision Support Alerts to Reduce Telemetry Duration: A Multicenter Evaluation
Authors: Latifi Niloofar , Johnson Trent , Knight Amy M. , Prichett Laura , Modanloo Bahareh , Dungarani Trushar , Zakaria Sammy , Pahwa Amit
Published: October 2024

Background Telemetry monitoring is crucial for high-risk patients but excessive use beyond practice standards increases costs. Prior studies have shown that electronic health record (EHR) alerts reduce low-value telemetry monitoring. However, specific components of these alerts that contribute to effectiveness are unknown.

Objectives We aimed to revise previously implemented EHR Best Practice Advisories (BPAs) to optimize their effectiveness in reducing telemetry duration. The secondary objective was to assess the impact on clinicians' alert burden.

Methods A multicenter retrospective study was conducted at Johns Hopkins Hospital (JHH), Johns Hopkins Bayview Medical Center (JHBMC), and Howard County General Hospital (HCGH). An EHR alert in the form of a BPA was previously implemented at JHH/JHBMC, firing at 24, 48, or 72 hours based on order indication. HCGH used an alert firing every 24 hours. A revised BPA was implemented at all hospitals optimizing the prior JHH/JHBMC alert by including patient-specific telemetry indications, restricting alerts to daytime hours (8:00 a.m.–6:00 p.m.), and embedding the discontinuation order within the BPA alert. A retrospective analysis from October 2018 to December 2021 was performed. The primary outcome was telemetry duration. The secondary outcome was the mean monthly BPA alerts per patient-day.

Results Compared with the original BPA, the revised BPA reduced telemetry duration by a mean of 6.7 hours (95% CI: 5.2–9.1 hours, p < 0.001) at JHH/JHBMC, with a minimal increase of 0.06 mean monthly BPA alerts per patient-day (p < 0.001). The BPA acceptance rate increased from 7.8 to 31.3% postintervention at JHH/JHBMC (p < 0.0001). At HCGH, the intervention led to a mean monthly reduction of 20.2 hours in telemetry duration per hospitalization (95% CI: 19.1–22.8 hours, p < 0.0001).

Conclusion Optimizing EHR BPAs reduces unnecessary telemetry duration without substantially increasing clinician alert burden. This study highlights the importance of tailoring EHR alerts to enhance effectiveness and promote value-based care.
The Spondylocarpotarsal Synostosis Syndrome Case with Ventricular Septal Defect Caused by a Homozygous Frameshift Variation in FLNB
Authors: Dirimtekin Esra , Ates Esra Arslan , Polat Hamza , Almus Eda , Geckinli Bilgen B.
Published: October 2024

Spondylocarpotarsal synostosis syndrome (SCT) (OMIM: 272460), an autosomal recessive disorder, is characterized by block vertebrae, carpal–tarsal synostosis, and disproportionate short stature. The clinical features of SCT include dysmorphic facial traits, cleft palate, hypoplastic tooth enamel, brachydactyly, clinodactyly, limited joint movement, and mixed hearing loss. SCT is associated with biallelic nonsense and frameshift pathogenic variants in the FLNB gene. An 8-year-old patient was referred with suspected skeletal dysplasia. The patient presented with short stature, scoliosis, carpal–tarsal synostosis, and ventricular septal defect (VSD). Clinical exome sequence analysis revealed a homozygous frameshift variation in the FLNB gene (c.219_222dup p.Met75Profs*17). No other pathogenic variations in genes related to VSD were found. This study aims to discuss novel clinical findings related to the genotype–phenotype association. To the best of our knowledge, this is the first reported case of SCT with VSD.
Semiparametric maximum likelihood reconstruction of stochastic differential equations driven by white and correlated noise
Authors: Kwasniok F.
Published: October 2024

A semiparametric methodology for reconstructing Markovian and non-Markovian Langevin equations from time series data using unscented Kalman filtering is introduced and explored. The drift function and the logarithm of the diffusion function are expanded into sets of polynomial basis functions. In contrast to the more common state augmentation approach, the Kalman filter is here used only for state estimation and propagation; the model parameters are determined by maximum likelihood based on the predictive distribution generated by the Kalman filter. Model selection regarding the number of included drift and diffusion basis functions is performed with the Bayesian information criterion. The method is successfully validated on various simulated datasets with known system dynamics; it achieves accurate identification of drift and diffusion functions, also outside the prescribed model class, from datasets of moderate length with medium computational cost.
Global boundedness and asymptotic stability for a food chain model with nonlinear diffusion
Authors: Xu Lu , Zhang Yun , Yang Li
Published: October 2024

This paper is concerned with a food chain model with nonlinear diffusion ut = Δu + u(1 − u − b1v), vt=∇⋅((v+1)m∇v)−∇⋅(ξv∇u)+vu−b2w1+v+w−θ1−α1v,wt=∇⋅((w+1)l∇w)−∇⋅(χw∇v)+wv1+v+w−θ2−α2w in a smooth bounded domain Ω ⊂ Rn(n ≥ 2) with homogeneous Neumann boundary conditions, where the parameters ξ, χ, α1, bi, θi  (i = 1, 2) > 0 and α2 ≥ 0 as well as m, l∈R. We study the global boundedness of classical solutions to the problem if either n = 2 and m ≥ 0, l > − 1 or n ≥ 3 and m>1−2n, l > − 1. Moreover, we prove the global stability of the prey-only steady state and semi-coexistence steady as well as coexistence steady states under certain conditions on parameters.
Table-top laser-based terahertz high harmonic generation spectroscopy under magnetic fields and low temperatures
Authors: Wang X. B. , Wang H. , Yuan J. Y. , Zeng X. Y. , Cheng L. , Qi J. , Luo J. L. , Dong T. , Wang N. L.
Published: October 2024

We have developed a terahertz (THz) nonlinear spectrometer at low temperatures (1.5–300 K) and under high magnetic fields (up to 10 T) by combining the laser-driven table-top intense THz source with a superconducting magnet. The strong-field THz pump pulse was generated from LiNbO3 crystal using the tilted-pulse-front technique and tightly focused into the center of the magnet by an off-axis parabolic mirror and a THz lens. The electric fields at the focus can achieve 500 kV/cm with a monocycle waveform and 30 kV/cm with a multicycle waveform at 0.5 THz. The sample was mounted on a low-temperature motorized rotation stage, which enables performing the polarization dependent measurements of the third harmonic generation (THG) intensity without rotating the incident THz pulses. The magnetic field direction can be rotated using a mechanical rotator, allowing for a convenient switch between Faraday and Voigt geometry. We demonstrate the excellent performance of our instrument by conducting THG measurements in the two-band superconductor MgB2 as a function of temperature, sample azimuth angle, as well as in-plane and out-of-plane magnetic fields. The successful combination of the strong field THz source with magnetic fields enables us to study a variety of materials with magnetic-field-dependent properties of interest.