bluuebunny/crossref_metadata_2025 huggingface dataset:
Determinasi Profitabilitas Pada Perusahaan Manufaktur Sektor Barang Konsumsi
Authors: Evi Husnah  , Iwan Setiadi
Published: August 2021

This study aims to analyze the effect of Current Ratio, Total Asset Turnover, Debt to Equity and Firm Size on Profitability in Manufacturing Companies in the Consumer Goods Industry Sector in 2011-2017. The design of this study is causal associative. The population of this study includes all Manufacturing Companies of the Consumer Goods Industry Sector Listed on the Indonesia Stock Exchange during 2011-2017. Sample selection techniques using purposive sampling method and research data obtained by 20 companies. The data analysis technique is done by using Descriptive Statistical Analysis, Classic assumption test which includes normality test, autocorrelation test, heteroscedasticity test and multicollinearity test, Multiple Linear Regression Test and Model Feasibility Test which include Determination Coefficient Test, T test and F Test. The research results partially show the Current Ratio has a negative and not significant effect on Return on Assets. Total Asset Turnover and company size have a positive and significant effect on Return on Assets, and Debt to Equity Ratio has a negative and significant effect on Return on Assets. But Simultaneously it is known that CR, TATO, DER and Size have a significant effect on ROA.
Integrity Of Financial Statements And The Factors
Authors: Abbas Dirvi , Siregar Indra Gunawan , Basuki
Published: August 2021

The purpose of this study is to determine the effect of corporate governance, company size, and leverage on the integrity of financial statements partially in essential industrial and chemical manufacturing companies listed on the Indonesia Stock Exchange (IDX) and using the 2013-2017 research period. The study population includes companies. Essential industrial and chemical manufacturing sectors listed on the Indonesia Stock Exchange for the period 2013-2017. The sampling technique was using the purposive sampling technique. Based on the predetermined criteria, a total sample of 7 companies was obtained. The type of data used is secondary data obtained from the Indonesia Stock Exchange website. The data analysis method used is a panel data regression analysis with the help of Eviews 9.0. Based on this research, it can be concluded that the independent commissioner has an effect, the audit committee on the integrity of financial statements, and leverage has no impact on the integrity of the financial statements.
Pola Pengelolaan Good University Governance Badan Layanan Umum
Authors: Nurlatifah Amira , Suratman Bambang , Hariyati
Published: August 2021

Implement good governance in Higher Education, the government established a Public Service Agency with the aim of improving the quality of higher education services. The purpose of this study was to determine the meaning of good corporate governance, the application of the management patterns of good corporate governance in universities and the obstacles faced by good corporate governance in universities. This research is a qualitative research which is literature study. The results of the study reveal that good corporate governance has the meaning of a good governance system, especially important in universities based on the principles of good governance in universities, such as the principle of accountability which is manifested in positive and negative independence without pressure from any party, as well as the principle of equality and fairness to stakeholders. Apart from this, there are internal problems, one of which is due to the inadequate duties and functions of special institutions dealing with development. Meanwhile, external problems occur due to the rapid development of science and technology that does not yet fulfill sufficient capacity to implement good governance in the management of education in Indonesia
Meningkatkan Kinerja Pemasaran Hotel dengan Memanfaatkan Nilai Pelayanan Ergo-ikonik
Authors: Andriyansah Andriyansah , Fatimah Fatia , Hidayah Zainur , Daud Anshar
Published: August 2021

The present study aims to support the hypotheses proposed in the research model to prove the fact that the suggested variables can contribute towards performance improvement. The study offers a novel variable namely ergo-iconic service value. The object of this study includes 118 three-star hotels located in the business districts of the Special Capital Region of Jakarta and West Java. The study used questionnaires that were distributed to hotel managers to acquire research data. The ergo-iconic service value as a mediating variable is proven to improve the marketing performance of the hotels. Other variables, namely, the ability to implement management system certification and the ability to adapt to technology also increase the mediating role of ergo-iconic service value. The hypotheses are empirically proven as all three variables successfully improved the hotels' marketing performance. The current research also shows that the role of humans is still significant, and human presence is required to improve performance despite the fact that we are currently at the Industry 4.0 era; in this case, not all activities should be taken over by robots.
Pengaruh Kepemilikan Institusional, Konsentrasi Kepemilikan Dan Dividen Terhadap Kinerja Perusahaan
Authors: Wikartika Ira , Syaiful Akbar Fajar
Published: August 2021

Improving company performance is crucial for the company's future life continuity. The company has a primary objective that increases the prosperity of shareholders. Basically,  investors expect returns in the form of dividends. The structure of ownership and dividends is one way to improve the company's performance. This research aims to determine the influence of institutional ownership, ownership concentration, and dividends on the company's performance. The research methods used are quantitative methods using multiple linear regression analysis techniques. The research population uses companies listed on LQ45 in the Indonesia Stock Exchange. Sample research of 45 companies during the year 2018. The results showed that institutional ownership and ownership concentration did not affect the company's performance while dividends were influential in the company's performance.
Pengaruh Citra Merek, Kepercayaan Merek dan Sikap Merek terhadap Minat Menjadi Nasabah Tabungan dan Giro Bank Panin (Studi pada Bank Panin KCP Tambak Langon Surabaya)
Authors: Al Azis Mochamad Syaifudin , Harsono Soni
Published: August 2021

Pada era Globalisasi persaingan bisnis antar Bank semakin ketat. Bank yang ingin terus berkembang dan meningkat harus mampu memberikan produk yang berkualitas. Namun, untuk menjadi Bank yang unggul dalam persaingan bukanlah sebuah hal yang mudah, diperlukan pengelolaan manajemen yang bagus dan berkualitas. Selain itu dibutuhkan pula strategi yang maksimal.

Menurut UU RI No.10 1998, Bank merupakan badan usaha yang menghimpun dana dari masyarakat dalam bentuk simpanan dan menyalurkannya kepada masyarakat dalam bentuk kredit dan atau bentuk-bentuk lainnya dalam rangka meningkatkan taraf hidup masyarakat banyak. OJK mencatat hingga akhir Desember 2018, ada sebanyak 115 Bank di Indonesia dengan komposisi ada 5 Bank BUKU IV  dan menguasai 51,03% asset perbankan. Bank BUKU III ada 28 Bank dengan pengusaan asset 35,23%. Bank BUKU II sebanyak 59 Bank dengan pangsa asset 12,65% dan Bank BUKU I sebanyak 22 Bank dan penguasaan asset hanya 1,08%. Di antara Bank tersebut, terdapat Bank Panin yang didirikan pada tahun 1971 yang merupakan hasil dari merger dari 3 Bank, yaitu Bank Kemakmuran, Bank Industri Jaya dan Bank Industri Dagang Indonesia. Berdasarkan data keuangan per September 2018, Bank nasional dengan asset tertinggi masih  disematkan pada Bank BRI, peringkat ke dua terdapat Bank Mandiri, diikuti secara berututan Bank BCA, Bank BNI, Bank BTN, Bank CIMB Niaga, Bank Panin, Bank OCBC NISP,
Pendelegasian Sebagian Kewenangan Bupati Terhadap Efektifitas Kinerja Kecamatan di Kabupaten Sidoarjo
Authors: Ubaidillah Hasan
Published: August 2021

Penelitian ini mengenai pendelegasian sebagian kewenangan Bupati yang dalam implementasinya berpengaruh pada efektivitas kinerja kecamatan di kabupaten Sidoarjo. Dengan menggunakan pendekatan kualitatif, penelitian ini mendiskripsikan tentang efektifitas kinerja yang dilihat dari pelaksanaan kegiatan dan kapasitas sumberdaya manusia. Hasil penelitian menunjukkan bahwa kebijakan pendelegasian sebagian kewenangan Bupati kepada Camat di Kabupaten Sidoarjo masih kurang optimal. Selain dari pelaksanaan pendelegasian yang masih bersifat adminitratif dan menggunakan pola penyeragaman dimasing masing kecamatan tanpa mempertimbangkan perbedaan potensi karakter kecamatan.
Model Of Correlation Of Work Motivation and Organizational Commitment Through Workplace Spirituality and Servant Leadership
Authors: Amalia Lia Amalia , Nurafian Basman
Published: August 2021

This study aims to determine the effect of Servant Leadership on Organizational Commitment through Workplace Spirituality and Work Motivation. The independent variable consists of Servant Leadership, the dependent variable is Organizational Commitment and the intervening variables are Workplace Spirituality and Work Motivation. This research was conducted on millennial-generation employees who worked for more than one year within Tangerang area. The samples used were 160 respondents with purposive sampling technique. This type of research is causal associative in nature and the method used in this research is Path Analysis. The results of this study indicate that Servant Leadership has positive and significant effect on Workplace Spirituality and Work Motivation. Workplace Spirituality and Work Motivation have a positive and significant effect on Organizational Commitment, while Servant Leadership does not have a positive and significant effect on Organizational Commitment. Workplace Spirituality and Work Motivation have successfully become the Intervening variables for Servant Leadership.
Sharia Cooperative Financial Inclusion and Entrepreneurial Orientation To Improve Sharia-Based MSME Empowerment New Normal Era In Malang City
Authors: Raisa Fitri  , Murniati Aniek
Published: August 2021

The problem that is faced by Islamic boarding school-based MSMEs is capital constraints. This capital constraint is due to the lack of information on MSME actors about how to apply for credit and how to utilize financing funds. Financial inclusion can be realized, there is a need for parties who have direct contact with the community, especially the lower middle class in terms of distributing micro credit. Therefore, the role of sharia banking and sharia cooperatives needs to be increased to increase the growth of MSMEs in Malang City, especially Sharia-based MSMEs so that financial inclusion can be realized. Based on the results of a survey conducted through the Cooperatives and MSMEs Offices, there are about 25 Sharia cooperatives with several criteria, namely cooperatives in Malang City that are legal entities. The multiple regression was chosen to be carried out in this research activity. The results of the study show that the good performance of an MSMEs can be seen from its entrepreneurial orientation because the increasing spirit of entrepreneurial orientation will motivate MSMEs to make innovations and be ready to face all possible risks in the future.
Mathematics Teachers' Understanding in Developing Learning Indicators in Preparing Lesson Plans
Authors: Nopriana Tri , Dian Nopitasari  , Dahlan Jarnawi Afgani
Published: August 2021

Research on teachers' ability to prepare lesson plans has not shown good results, whereas there have been many studies on efforts to improve teachers in preparing lesson plans. Still, no research explicitly describes the ability of teachers to develop indicators. This research aims to describe the understanding of mathematics teachers in creating learning indicators. This research is quantitative research with a survey method. The sur- vey was conducted on 51 Mathematics Teachers in Cirebon City. The research instrument used was in the form of a questionnaire regarding the indicators of developing learning indicators. The results showed that (1) most teachers still did not understand the steps of developing learning indicators (2) teachers still had difficulty determining operational verbs (KKO) of knowledge, conducting processes, implementation, and evaluation, (3) there were still teachers who thought the affective and psychomotor aspects could not be assessed in mathematics, (4) most teachers have developed at least three indicators in a basic competency, while almost half of the sample assumes the characteristics of students and schools do not affect developing learning indicators.
Developing Entrepreneurial Interest and Student Independence through Project-Based Entrepreneurship Learning
Authors: Erwantiningsih Eni , Wahyuni Hari , Immadudin Waladi
Published: August 2021

The purpose of this study was to determine (1) How the contribution of project-based entrepreneurship learning; (2) What is the student's entrepreneurial interest; (3) How independent are students; (4) How does project-based entrepreneurship learning affect students' entrepreneurial interest and independence. The method in this research is quantitative survey. According to the results of the study, the t-count value is 5.517 and the t-table number is 2.002, so that t-count> t-table, which means that there is a significant influence between Project-Based Learning on Entrepreneurial Interest, while the magnitude of the influence is obtained a coefficient value of 0.669 for the effect of learning. project based on entrepreneurial interest. Meanwhile, for the effect of entrepreneurship learning on student independence, the t-count is 5.993 and the t-table number is 2.002, so that t-count> t-table. This means that there is a significant influence between project-based learning on independence. There is also a coefficient value of 0.696, which means that when there is an increase in project-based learning, it will increase Independence by 0.696. Meanwhile, the correlation coefficient value is 0.618 and the coefficient of determination (R2) is 0.382. This means that there is an influence between the Project-Based Learning variable on Independence of 38.2% while the remaining 61.8% is influenced by other variables that the researchers did not involve in this study.
A Misconception Investigation of Ninth Grade Students about Magnetism
Authors: Shofiyah Noly
Published: August 2021

This study aimed to identify the ninth grade students' misconceptions related to magnetism topic. For this purpose, an instrument consisting of two phases (two-tier) with fourteen multiple choice items on magnetism concepts was developed by the researcher. The diagnostic test was given to thirty-two ninth grade students. The findings indicated that 9th grade students experience misconceptions about the concept of magnetism including how to make and determine artificial magnetic poles, Lorentz force and GGL Induction. The results of this study can be used by teachers and researchers to choose substantial learning strategies for teaching magnetism material.
Aligning research and monitoring priorities for benthic cyanobacteria and cyanotoxins : a workshop summary
Authors: Pokrzywinski Kaytee , Volk Kaitlin , Rycroft Taylor , Wood Susie , Davis Tim , Lazorchak Jim
Published: August 2021

In 2018, the US Army Engineer Research and Development Center partnered with the US Army Corps of Engineers–Buffalo District, the US Environmental Protection Agency, Bowling Green State University, and the Cawthron Institute to host a workshop focused on benthic and sediment-associated cyanobacteria and cyanotoxins, particularly in the context of harmful algal blooms (HAB). Technical sessions on the ecology of benthic cyanobacteria in lakes and rivers; monitoring of cyanobacteria and cyanotoxins; detection of benthic and sediment-bound cyanotoxins; and the fate, transport, and health risks of cyanobacteria and their associated toxins were presented. Research summaries included the buoyancy and dispersal of benthic freshwater cyanobacteria mats, the fate and quantification of cyanotoxins in lake sediments, and spatial and temporal variation of toxins in streams. In addition, summaries of remote sensing methods, omic techniques, and field sampling techniques were presented. Critical research gaps identified from this workshop include (1) ecology of benthic cyanobacteria, (2) identity, fate, transport, and risk of cyanotoxins produced by benthic cyanobacteria, (3) standardized sampling and analysis protocols, and (4) increased technical cooperation between government, academia, industry, nonprofit organizations, and other stakeholders. Conclusions from this workshop can inform monitoring and management efforts for benthic cyanobacteria and their associated toxins.
The Impact of Gridded Weather Database on Soil Water Availability in Rice Crop Modeling
Authors: Menezes Caio Teodoro , Casaroli Derblai , Heinemann Alexandre Bryan , Moschetti Vinicius Cintra , Battisti Rafael
Published: August 2021

In recent years, there has been an increase in studies suggesting that gridded weather database (GWD) is a suitable source for simulating crop yield. Brazil has low geospatial coverage by measured weather database (MWD). Based on that, this study aimed to compare two different GWD sources, Daily Gridded (DG) and NASA/POWER (NP), on the simulated yield of upland rice (UR) against the MWD input. The GWD and MWD were obtained for seven locations across UR Brazilian region, considering a period ranging from 1984 to 2016. GWD and MWD were used to estimate rice potential (Yp) and attainable yield (Ya), in clay soil and sandy soil, using ORYZA (v3) model. DG had the best performance for all variables. GWD-based yields had a reasonable performance. However, DG had a slightly better performance than NP in all conditions, DG-based yields showed RMSE values of 0.57, 0.71 and 0.52 for Yp and Ya in clay and sandy soil, whereas NP showed RMSE values of 0.86, 0.91 and 0.64. DG also showed higher R² and d values for yields assessed. Both GWD overestimated Ya, these overestimations in DG-based yield were 3.54, 9.61, and 21.35% for Yp and Ya in clay and sandy soil respectively, in NP-based yield were 13.67, 18.45, 29.11%, showing that for both GWD-based yield increased as the soil type texture as well as water storage decreased. As a consequence, we do not recommend the use of precipitation data in daily time-step crop modeling.
Generalised Geometric Logic
Authors: Jana Purbita
Published: August 2021

This paper introduces a notion of generalised geometric logic. Connections of generalised geometric logic with L-topological system and L-topological space are established.
The Study of Distance Changes Between Lumbar Bi-Cortical Pedicle Screws and Anterior Large Vessels in Patients with Lumbar Spondylolisthesis
Authors: Zhao Li , Wan Chenguang , Han Shuhong , Zheng Shaoyi , Li Baofeng
Published: August 2021

Objective: This paper was a anatomical radiographic study of distance between lumbar bi-cortical pedicle screws (BPSs) and anterior large vessels (ALVs) in patients with lumbar spondylolisthesis, and to provide clinical basis for evaluating the safety of bi-cortical pedicle screw implantation during lumbar spondylolisthesis.Methods: Complete Computed tomography (CT) data of 104 patients with grade I lumbar spondylolisthesis (L4 52 and L5 52) and 107 non-spondylolisthesis patients (control group) were collected in this study. The distances between lumbar 4,5(L4,5) and sacrum 1(S1) BPSs and ALVs (abdominal aorta, inferior vena cava, left and right common iliac artery, internal and external iliac artery) were respectively measured at different transverse screw angles (TSAs) (L4:5°,10°; L5:10°,15°; S1:0°,5°,10°) and analyzed by SPSS (v25.0). There were three types of distances from the anterior vertebral cortex (AVC) to the ALVs (DAVC-ALV): DAVC-ALV N, DAVC-ALV ≥ 0.50 cm, and DAVC-ALV < 0.50 cm; these different distances represented non-contact, distant and close ALV respectively.Results: We calculated the incidences of large vessels damage at different TSAs and provided the appropriate angle of screw implantation. In non-spondylolisthesis group, in L4, the appropriate left TSA was 5°, and the incidence of the close ALV was 4.62%. In S1, the appropriate left TSA was 0° and the incidence of the close ALV was 22.4%, while the appropriate right TSA was 10° and the incidence of the close ALV was 17.8%. In L4 spondylolisthesis group, in L4, the appropriate left TSA was 5°, and the incidence of the close ALV was 3.8%. In L5 spondylolisthesis group, in S1, the appropriate left TSA was 0° and the incidence of the close ALV was 19.2%, while the appropriate right TSA was 10° and the incidence of the close ALV was 21.2%. The use of BPS was not appropriate on the right side of either L4 or on the either side of L5 both in spondylolisthesis and control group. In patients with lumbar 4 spondylolisthesis, the incidences of large vessels damage were less than the control group in both L4 and 5. In patients with lumbar 5 spondylolisthesis, the incidences of large vessels damage were less than the control group in L5, while there were no significant difference in S1.Conclusion: It is very important that considering the anatomical relationship between the AVC and the ALVs while planning BPSs. The use of BPS do not apply to every lumbar vertebra. In patients with lumbar spondylolisthesis and non-spondylolisthesis patients, the incidences of large vessels damage are different.
Randomized Double-Blind Clinical Trial Comparing Safety and Efficacy of the Biosimilar BCD-021 with Reference Bevacizumab
Authors: Stroyakovskiy Daniil , Fadeeva Natalya , Matrosova Marina , Shelepen Konstantin , Adamchuk Grigoriy , Roy Bodhisatta , Nagarkar Rajnish , Kalloli Mahesh , Zhuravleva Daria , Voevodin Georgiy , Shustova Mariya , Kryukov Fedor
Published: August 2021

Background
BCD-021 is a bevacizumab biosimilar which was shown to be equivalent to reference bevacizumab in a wide panel of physicochemical studies as well as preclinical studies in vitro and in vivo. International multicenter phase III clinical trial was conducted to compare efficacy and safety of BCD-021 and reference bevacizumab in combination with paclitaxel and carboplatin in a first-line treatment of inoperable or advanced non-squamous non-small-cell lung cancer (NSCLC).
Methods
Patients with no previous treatment for advanced non-squamous NSCLC were randomly assigned 3:2 to BCD-021 or reference bevacizumab and were treated with bevacizumab + paclitaxel + carboplatin. Therapy continued for 6 cycles (every 3 weeks), until progression of the disease or unbearable toxicity. The primary study endpoint was the overall response rate. The study goal was to prove the equivalent efficacy of BCD-021 and reference bevacizumab. Equivalence margins for 95% CI for the difference in the overall response rates were set at [-18%; 18%], for 90% CI for the ratio of overall response rate were set at [67%; 150%].
Results
In total 357 patients were enrolled in the study, 212 in the BCD-021 group and 145 in the reference bevacizumab group. The ORR was 34.63% in the BCD-022 group and 33.82% in the reference bevacizumab group. Limits of 95% CI for the difference in overall response rates between the groups were [-9.47%; 11.09%]. Limits of 90% CI for the ratio of overall response rate between the groups were [79.6%; 131.73%]. For both approaches CI lied within predetermined equivalence margins. Profile of adverse events (AEs) was similar between the groups (any AEs were reported in 86.89% of patients in BCD-021 group and 89.05% of patients in reference group). No unexpected adverse reactions were reported throughout the study. No statistically significant differences regarding anti-drug antibody occurrence rate was found between BCD-022 (n = 4; 1.96%) and comparator (n = 5; 3.65%). Both drug products showed low occurrence rate and short life of anti-bevacizumab antibodies. Pharmacokinetics assessment after 1st and 6th study drug injection also demonstrated equivalent PK parameters by all outcome measures.
Conclusions
Thus, the results of this study demonstrated therapeutic equivalence of bevacizumab biosimilar BCD-021 and referent bevacizumab drug.
Trial registration:
The trial was registered with ClinicalTrials.gov (Study Number NCT01763645, date of registration 09/01/2013).
Biological Characteristics And Genomic Analysis of A Novel Bacteriophage BUCT609 Infecting Stenotrophomonas Maltophilia
Authors: Han Ke , Fan Huahao , Li Fei , Tong Yigang
Published: August 2021

Stenotrophomonas maltophilia is widely distributed in nature and has a high isolation rate in nosocomial infections. Due to its potential application and important role in clinical practice, the relevant studies of S.maltophilia have received much attention. S.maltophilia phage BUCT609 (GenBank: MW960043) was isolated from hospital sewage with S.maltophilia strain No. 3015 as a host. Morphologically, it can be inferred as Podoviridae phage from the result of transmission electron microscopy (TEM). The electron microscopy also shows that the phage has an isometric capsid ~50 nm in diameter. The one-step growth curve demonstrated that the incubation period of 10 min and the burst size is 382 pfu/cell when its optimal multiplicity of infection (MOI) is 0.01. Phage BUCT609 had a high survival rate at pH 3 to 10 and tolerant temperature from 4 ℃ to 55 ℃. Next-Generation Sequencing (NGS) results demonstrated that its complete genome is linear double-stranded DNA of 43145 bp in length, and the GC content is 58 %. It has very little resemblance to other phages. The BlastN analysis shows that the genome of phage BUCT609 shares 22 % homology with S.maltophilia phage Ponderosa (GenBank: MK903280.1), and it encodes 56 putative proteins, of which only 25 have annotated function. Phage BUCT609 with a relatively large burst size and excellent survival ability in a wide pH and temperature range, suggests BUCT609 is a potential alternative for multi-drug resistance S.maltophilia therapy.
A comparative analysis of Heat Shock Factor 1 in Cancer
Authors: Choudhury Shouhartha
Published: August 2021

The heat shock factor 1 (HSF1) is a DNA-binding factor that has responses under proteotoxic stress is well-known as an HSF. Heat shock factor 1 is a unique regulator that coordinates chaperone expression to enhance organism growth. Specifically, HSF’s drive transcriptional strategy is apparent from the HSP’s and promotes cell viability. A recent study supported the HSF1 coordinated with different cancer and robust in cancer immunotherapy. In this research, I designed to genome-wide analysis of HSF1 and its family in mammals. A comparative analysis of HSF’s is mandatory to explore functions and immunogenic mechanisms involved with HSP’s in organisms. Therefore, I performed a bioinformatics pipeline and tools to the current knowledge of HSF’s in two different organisms. This application can enhance in a significant way to study particular HSF’s in discrete organisms. My finding data demonstrated the number of HSF1 and their family in Homo sapiens and Mus musculus. The conserved domain, motifs, phylogeny, chromosome location, gene network, and expression analysis documented the HSF1 associated with cancer. The analysis data concluded the HSF1 is impact in various cancers and a signature of cancer immunotherapy.
A New Risk Score Assessment for Neck Management in T1-T2N0 Sinonasal Squamous Cell Carcinoma Patients: A European Head and Neck Cancer Center Survey Study and Evaluation of 58 Patients with Early Stage Sinonasal Carcinoma
Authors: Lill Claudia , Erovic Boban , Seemann Rudolf , Faisal Muhammad , Stelter Klaus , Gandler Bernd , Frommlet Florian , Janik Stefan
Published: August 2021

Purpose

The purpose of the present study was to assess whether European head and neck cancer centers perform elective neck dissection (END) in early stage sinonasal squamous cell carcinomas (SCCs) and whether END affects oncological outcome.
Methods

A questionnaire regarding performance of END in T1 - T2 sinonasal SCCs was sent to 38 head and neck cancer centers in Europe. The results were further correlated and compared with clinical data of 58 patients with T1 (n = 37) and T2 (n = 21) sinonasal SCCs, a risk score and a nomogram were generated.
Results

Only 5–10 % of respondents are performing END in T1 and 26–32% in T2 sinonasal SCCs. In our cohort regional recurrence was evident in 10 (17.2%) patients, representing a significant worse prognostic factor for cancer specific survival (HR 8.13; p = 0.016). Particularly, regional recurrence was more frequent in T2 tumors and in patients where the primary tumor originated from nasal septum and vestibule. Based on our clinical and questionnaire data a new risk-score was determined to predict necessity for END. The risk-score, including T-classification and tumor site, assigned T1-classification with 0 points, followed by 1 point for T2; tumor site: nasal septum or vestibule with 1 point and tumors from other subsites with 0 points. Based on these factors we further created a nomogram for predicting the risk of regional recurrence. Patients with a high-risk score showed 9.52-fold higher risk for regional and or distant recurrence (HR 9.52; p = 0.002;) and their 5-year CSS was 44.4% compared to 92.8% in patients with moderate or low risk (p = 0.017).
Conclusions

Our proposed risk-score system in T1-2N0 sinonasal carcinoma is helpful to identify patients who may benefit from END. Although to date END has no value in European head and neck cancer centers for T1-T2 sinonasal SCCs, our study indicates that the neck management in these patients should be reconsidered.
Covid-19 in Liver Transplant Recipients: An Italian Case-Control Double-Centre Study.
Authors: Guarino Maria , Cossiga Valentina , Loperto Ilaria , Esposito Ilaria , Ortolani Rosanna , Fiorentino Andrea , Pontillo Giuseppina , De Coppi Lucia , Cozza Valentina , Lanza Alfonso Galeota , Costanzo Giovanni Giuseppe Di , Picciotto Francesco Paolo , Morisco Filomena
Published: August 2021

Background and Aims: Liver transplant (LT) recipients are vulnerable to SARS-CoV-2-infection (COVID-19), due to immunosuppression and comorbidities. This study aimed to evaluate the impact of COVID-19 on LT recipients compared to general population in the Campania region.Methods: In this case-control double-centre study, we enrolled all consecutive adult LT recipients with confirmed SARS-CoV-2-infection. Data were collected at diagnosis of COVID-19 and during follow-up and compared with the regional population. Results: Thirty LT recipients (3.28%) developed SARS-CoV-2-infection (76.6% male, median age 62.6 years). Sixteen (53.3%) were symptomatic. Common symptoms were fever, cough, fatigue, and anosmia. Twenty-five (83.4%) were outpatients, 5 (16.6%) required hospitalization (6.6% admitted to Intensive Care Unit, 6.6% developed Acute Respiratory Distress Syndrome and 6.6% died). Immunosuppressors were in 3 (10%) patients. Incidence rate of COVID-19 was similar between LT patients and general population (3.28% vs 4.37%, p=0.1) with higher rate of symptoms in LT patients (46.67% vs 15.87%, p<0.00). At univariate analysis, hospitalization and case fatality rates were higher in LT patients compared to general population (16.67% vs 4.54%, p=0.001; and 6.67% vs 1.76%, p=0.04, respectively). At multivariable logistic regression analysis, LT patients with COVID-19 were more frequently symptomatic (OR 5.44 [95%CI 2.44-12.17], p<0.00), whereas hospitalization and death for COVID-19 were not significatively associated with LT condition (p=0.72 and p=0.46, respectively) and were comparable with general population.Conclusions: LT is not a risk factor for acquiring COVID-19. Nonetheless, LT patients are more frequently symptomatic, although comparable to the general population for hospitalization rate and mortality.
Silicon Wearable Body Area Antenna for Speech Enhanced IOT and Medical Applications
Authors: Vignesh N Arun , S Kanithan , S Jana , C Gokul Prasad , E Konguvel , Panigrahy Asisa Kumar
Published: August 2021

We propose in this paper a reduction in the size of wearable antennas on silicon (Si) for medicinal frameworks and Internet of things (IoT). This research also introduces one more type of dynamic patch antenna designed in favor of speech-enhanced healthcare applications. The most significant impediment to the adoption of smart correspondence and medical services frameworks is voice-enabled IoT. The primary objective of a body area network (BAN) is to give ceaselessly clinical information to the doctors. Actually wireless body area network is flexible, dense, trivial and less expensive. On the other hand the main disadvantage is low efficiency for small printed antenna. Microstrip silicon antenna recurrence is changed because of ecological conditions, distinctive reception apparatus areas and diverse framework activity modes. By using tunable antenna the efficiency of bandwidth usage can be increased. Amplifiers are associated with the feed line of antenna in order to build its dynamic range. In this study, a dynamic polarized antenna is constructed, analysed and attempted for fabrication. The gain of the antenna is 13 ± 2dB for the frequency range of 390 to 610MHz. The output of the polarized antenna is roughly 19 dBm. At different environmental conditions the performance and ability to control the antenna could vary. To achieve stable performance, we have used varactor diode and voltage controlled diode. This silicon wearable antenna can be fabricated and tested for many medical applications like health monitoring system, pacemakers etc. Furthermore, Micromachining techniques can be used to lower the practical dielectric constant of Silicon and hence improve radiation efficiency.
Weight Change, Lifestyle and Mortality in Patients With Type 2 Diabetes
Authors: Hu Jinbo , Hu Yang , Hertzmark Ellen , Yuan Chen , Liu Gang , Stampfer Meir J. , Rimm Eric B. , Hu Frank B. , Wang Molin , Sun Qi
Published: August 2021

Background: Whether weight change around type 2 diabetes (T2D) diagnosis is associated with long-term survival is unclear. We aimed to examine the association between weight change and mortality among participants with incident T2D and evaluate impacts of lifestyle on this association. Methods: This prospective analysis included 11,262 incident T2D patients from the Nurses’ Health Study and Health Professionals Follow-up Study. We assessed weight change bracketing T2D diagnosis in relation to mortality. We also examined potential effect modification by a healthy lifestyle consisting of high-quality diet, regular physical activity, non-smoking status and moderate alcohol consumption.Results: On average, T2D patients lost 2.3 kg during a two-year time-window spanning the T2D diagnosis, and body weight increased afterwards. Compared with patients with a stable weight, T2D patients who lost ≥10% body weight had a 26% (95% CI: 4%, 52%) increased mortality due to cardiovascular disease (CVD). Lifestyle significantly modified these associations: the hazard ratios (95% CIs) of CVD mortality comparing ≥10% weight loss with stable weight were 1.41 (0.87, 2.30) among participants with a deteriorated lifestyle, 1.46 (1.15, 1.86) for a stable lifestyle, and 0.82 (0.53, 1.27) for an improved lifestyle (Pinteraction <0.001). Major weight loss was also associated with an increased all-cause mortality, and similar effect modifications by lifestyle were observed.Conclusions: Significant weight loss upon T2D incidence was associated with an increased CVD mortality, although improved lifestyle quality abolished these associations. These results highlight the role of adopting a healthy lifestyle for newly diagnosed T2D patients in improving long-term survival.
Primary Treatment of Small-To-Medium (<3cm) Sporadic Vestibular Schwannomas: A Systematic Review And Meta-Analysis on Long-Term Hearing Preservation And Tumor Control Rates For Microsurgery Versus Radiosurgery.
Authors: Savardekar Amey Rajan , Terrell Danielle L , Lele Saudamini Jayant , Diaz Ryan Robert , Keesari Praneeth Reddy , Trosclair Krystle , Kosty Jennifer , Wang Chiachien Jake , Gardner Gale , Guthikonda Bharat
Published: August 2021

BackgroundOver the past two decades, the treatment of small-to-medium (<3cm) sporadic vestibular schwannomas (VS) has experienced a definite shift to stereotactic radiosurgery vis-a-vis microsurgery. We performed a systematic review and meta-analysis of VS patients primarily treated with stereotactic radiosurgery (SRS) or microsurgery (MS), with particular attention to hearing preservation outcomes (HPO), tumor control (TC), and facial nerve dysfunction (FND).MethodsA systematic review was conducted (Medline and Scopus database) for the period, January 2010 to June 2020 with appropriate MeSH. English language articles for small-to-medium sporadic VS (<3cm) utilizing SRS or MS as treatment modality, with minimum follow-up of 3 years, were included. Studies had to report an acceptable standardized hearing metric. HPO, TC, and FND rates were analyzed. ResultsThirty-two studies met inclusion criteria: 10 for microsurgery; 23 for radiosurgery (one comparative study included in both). HPO, at ~65 months follow-up, were comparable between MS group (10 studies; 809 patients) and SRS group (23 studies; 1234 patients) (56% versus 59%, p=0.1527). TC, at ~70 months follow-up, was significantly better in MS group (9 studies; 1635 patients) versus SRS group (19 studies; 2260 patients) (98% versus 92%, p < 0.0001). FND, at ~ 12 months follow-up, was significantly higher in MS group (8 studies; 1101 patients) versus SRS group (17 studies; 2285 patients) (10% versus 2%, p < 0.0001).ConclusionMS and SRS are comparable primary treatment options for small (<3cm) sporadic VS with respect to HPO at 5-year follow-up in patients with serviceable hearing at presentation. Approximately 50% patients for both modalities will likely lose serviceable hearing by that time-point. High TC rates (>90%) were seen with both modalities, with MS (98%) significantly better than SRS (92%). The post-treatment FND was significantly less with SRS group (2%) versus MS group (10%).
The Portuguese Man-of-war, One of The Most Dangerous Marine Species, Has Always Entered The Mediterranean Sea: Strandings, Sightings And Museum Collections
Authors: Badalamenti Rosario , Tiralongo Francesco , Arizza Vincenzo , Brutto Sabrina Lo
Published: August 2021

A search from different kinds of sources has been carried out to review the incidence of Physalia physalis, the Portuguese man-of-war, in the Mediterranean Sea; scientific and grey literature, social media, zoological museums were accessed. The records of the species were considered validated if documented with images or collected specimens. It was possible to date the putative first record of Physalia physalis in the Mediterranean Sea, thanks to a couple of colonies preserved in a historical collection, originating from the Gulf of Naples in 1914. Some massive strandings occurred in localities of the Alboran Sea, area of entrance from the Atlantic from where the species spread mainly along the Sicilian waters, in the central Mediterranean Sea. The records from the Italian maritime regions were then subdivided into three categories of risk according to the season of occurrence. These categories were created to assign a level of danger for swimmers to the sightings of Physalia physalis. The increasing sightings of such a poisonous organism in coastal waters can represent a risk to human health, and also to all those activities linked to the marine tourism sector. The involvement of citizens and touristic structures for the early detection of Physalia physalis can play a key role in preventing encounters with the species, allowing marine tourist facilities to operate within a range of reasonable security.
Application of cytokine-induced myeloid-derived suppressor cells mitigates murine pancreatic insulitis through inhibition of activated T cells
Authors: hsieh ching chuan , Lin Chun-Liang , Chiang Meihua , Chang Yong-Lin , He Jie-Teng , Hung Chien-Hui
Published: August 2021

Background

Type 1 diabetes is an inflammatory state. Myeloid-derived suppressive cells (MDSCs) originate from immature myeloid cells and quickly expand to control host immunity during infection, inflammation, trauma, and cancer. Immunotherapy is a method of disease treatment that involves stimulating or suppressing an immune response. Although the spleens and blood of tumor-bearing mice are the most common MDSC source for immunotherapy, many safety precautions must be considered.
Methods

Cytokine-induced MDSCs were propagated from bone marrow cells cultured with mouse recombinant granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-6, and IL-1β. Arginase-1 and inducible NO synthase (iNOS) expressions of MDSCs were evaluated using quantitative reverse-transcriptase PCR. Diabetes was diagnosed as a sustained blood sugar level > 350 mg/dL. The immunized T cells harvested from the spleens of nonobese diabetic (NOD) mice cotransplanted with cMDSCs were injected intravenously to the NOD mice with severe combined immune deficiency (SCID), twice a week for 5 consecutive weeks. Diabetes-free survival of NOD–SCID mice was measured. Fibronectin expressions of the renal glomerulus and insulin production of the pancreas were analyzed using immunohistochemistry studies.
Results

This study presents an ex vivo procedure to develop MDSCs from bone marrow cells propagated from GM-CSF, IL-6, and IL-1β cytokines expressing less costimulatory and more inhibitory surface markers as well as considerably high levels of the iNOS enzyme through the signal transducer and activator of transcription 1 (STAT1) signaling pathway. In addition, the MDSCs also displayed immature morphology and strong immunosuppression of T cell proliferation. The adoptive transfer of cMDSCs improved the hyperglycemic state in and prolonged the diabetes-free survival of NOD-SCID mice induced by reactive splenic T cells harvested from NOD mice. In addition, cMDSC use reduced fibronectin production in the renal glomeruli and improved pancreatic insulitis in the NOD–SCID mice.
Conclusions

The administration of cMDSCs propagated from GM-CSF, IL-6, and IL-1β cytokines provides an alternative immunotherapy protocol for the treatment of diabetic pancreatic insulitis and renal nephropathy.
Methylmercury Induced Apoptosis of Human Neuroblastoma Cells Through the ROS Mediated Caspase and PARP/AIF Dependent Pathways
Authors: Hou Shanshan , Zhang Xiayu , Ning Xiaofan , Wu Hao , Li Xinyue , Ma Kai , Hao Huifang , Lv Chunping , Li Chunrui , Du Zhongjun , Du Haiying , Jin Minghua
Published: August 2021

Methylmercury (MeHg) is an environmental neurotoxic substance, which can be absorbed by the human body through the digestive tract, and easily cross the blood-brain barrier, causing irreversible damage to the human central nervous system. Reactive oxygen species (ROS) are involved in various ways of intracellular physiological or pathological processes including neuronal apoptosis. The current studies attempted to explore the role of ROS-mediated PARP/AIF apoptosis signal in the process of MeHg inducing human neuroblastoma cells (SH-SY5Y) death. Here, the present studies found that SH-SY5Y cells underwent apoptosis in response to MeHg, which was accompanied by increased the levels of ROS and calcium ion, and the activation of caspase cascades and poly ADP-ribose polymerase (PARP). The decrease in ROS levels significantly reduced the expression of these proteins and the rate of apoptosis. Inhibition of caspase pathway can reduce the rate of apoptosis, but can not prevent the occurrence of apoptosis. Furthermore, inhibition of PARP signaling can significantly reduce the apoptosis rate and the expression of caspase pathway related proteins. Collectively, these results indicated that ROS mediated activation of caspase pathway and PARP /AIF signaling pathway are involved in MeHg induced apoptosis, and there is a certain relationship between the two pathways.
Significs of Lady Victoria Welby: Portrait in the interior of time
Authors: Скрипник К.Д.
Published: August 2021

В статье рассматриваются идеи сигнифики – науки о значении, сама концепция которой возникает на рубеже XIX–XX вв. благодаря леди Виктории Уэлби (1837–1912), имя которой на протяжении длительного времени было незаслуженно забыто. Описываются основные факты ее жизни, показана связь характеристик личности Уэлби и идей сигнифики в контексте интеллектуальной атмосферы ее времени. Личность и работы леди Уэлби оказали влияние на развитие философских и семиотических исследований, а также на установление связей между мыслителями различных стран. Заслуга Уэлби – в создании целостной динамической теории знака и значения, теории, интегрирующей различные аспекты изучения значения – от логико-лингвистических до аксиологических и практических.

The publication considers the ideas of significs-the science of meaning, the ideas and the concept of which arise at the turn of the nineteenth and twentieth centuries thanks to their author –Victoria Lady Welby (1837–1912), whose name for a long time was undeservedly forgotten. It describes the main facts of her life, shows the relationship between the characteristics of Welby's personality and the ideas of significs in the context of the intellectual atmosphere of her time. The personality and work of Lady Welby influenced the development of philosophical and semiotic research, as well as the establishment of connections between scholars from different countries. Welby's contribution is to create an integral dynamic theory of sign and meaning, a theory that integrates various aspects of the study of meaning - from logical-linguistic to axiological and practical.
The fate of an official: publishing activities of A. I. Miretsky
Authors: Крылова Е.Н.
Published: August 2021

В статье рассматривается судьба чиновника министерства финансов А.И. Мирецкого. На страницах организованного им в Киеве в 1911 г. журнала А.И. Мирецкий отражал настроения многочисленной группы малообеспеченных чиновников, недовольных условиями своего существования. Его деятельность способствовала знакомству чиновников с условиями труда и быта в других государственных учреждениях и частях Российской империи, осознанию ими собственных интересов и формированию стратегии по улучшению своего положения.

The article is devoted to the fate of an official of the Ministry of Finance, A.I. Miretsky, who established a magazine in Kiev in 1911. On the pages of his publication, Miretsky reflected the moods of a large group of low-income officials who were dissatisfied with the conditions of their existence. The publishing activity of Miretsky contributed to familiarizing officials with working and living conditions in other state institutions and parts of the Russian Empire, forming a strategy to improve their situation.