bluuebunny/crossref_metadata_2025 huggingface dataset:
PyRosetta Jupyter Notebooks Teach Biomolecular Structure Prediction and Design
Authors: Le Kathy H. , Adolf-Bryfogle Jared , Klima Jason C. , Lyskov Sergey , Labonte Jason W. , Bertolani Steven , Burman Shourya S. Roy , Leaver-Fay Andrew , Weitzner Brian D. , Maguire Jack , Rangan Ramya , Adrianowycz Matt A. , Alford Rebecca F. , Adal Aleexsan , Nance Morgan L. , Wu Yuanhan , Willis Jordan , Kulp Daniel W. , Das Rhiju , Dunbrack Roland L. , Schief William , Kuhlman Brian , Siegel Justin B. , Gray Jeffrey J.
Published: April 2021

Biomolecular structure drives function, and computational capabilities have progressed such that the prediction and computational design of biomolecular structures is increasingly feasible. Because computational biophysics attracts students from many different backgrounds and with different levels of resources, teaching the subject can be challenging. One strategy to teach diverse learners is with interactive multimedia material that promotes self-paced, active learning. We have created a hands-on education strategy with a set of 16 modules that teach topics in biomolecular structure and design, from fundamentals of conformational sampling and energy evaluation to applications, such as protein docking, antibody design, and RNA structure prediction. Our modules are based on PyRosetta, a Python library that encapsulates all computational modules and methods in the Rosetta software package. The workshop-style modules are implemented as Jupyter Notebooks that can be executed in the Google Colaboratory, allowing learners access with just a Web browser. The digital format of Jupyter Notebooks allows us to embed images, molecular visualization movies, and interactive coding exercises. This multimodal approach may better reach students from different disciplines and experience levels, as well as attract more researchers from smaller labs and cognate backgrounds to leverage PyRosetta in science and engineering research. All materials are freely available at https://github.com/RosettaCommons/PyRosetta.notebooks.
Stereoscopic photoacoustic imaging of radial artery for preoperative evaluation of coronary intervention
Authors: Qiu Tengsen , Duan Yihao , Cheng Zhongwen
Published: April 2021

Radial artery tortuosity (RAT) can lead to an increase in the failure rate of transradial coronary intervention (TRI). Before TRI, the radial artery morphology (RAM) needs to be evaluated to rule out those patients who have serious RAT, which has significant values in increasing the procedural success rate. A stereoscopic photoacoustic imaging (SPAI) system was developed to detect RAT. Phantom and human experiments were carried out to demonstrate performance of the SPAI system. The results show that the SPAI system has great clinical potential in assessing RAM for detecting RAT, which can provide an effective tool for preoperative evaluation of TRI.
Hemoptisis
Authors: Serrano Jennifer , Arriola-Navas José , Longo Alfredo , Marull Joselin
Published: April 2021

Mujer de 28 años quien presenta hemoptisis como manifestación tardía de trauma torácico penetrante.  Antecedente de trauma 9 años antes de consultar y de hemoptisis de 3 años de evolución. Los estudios radiológicos demostraron lesión cavitada en lóbulo inferior derecho. Se realizó lobectomía inferior derecha, con el hallazgo de cuerpo extraño (fragmento de madera) en tejido pulmonar. Paciente con buena evolución.
Dr. Igor Slowing
Authors: Chúa Carlos
Published: April 2021

Igor Slowing tiene 51 años de edad y es guatemalteco. Es Químico por la Universidad de San Carlos de Guatemala. Trabajó 8 años en docencia universitaria en Guatemala. Es Doctor en Química Orgánica por la Universidad Estatal de Iowa. En el año 2018, fue incluido en la lista de Web of Science de los primeros 100,000 científicos (top 1%) que más fueron citados en el mundo durante ese año.
Single-Ended Oscillation-Based Test Technique for Passive RF Phase Shifters
Authors: Venter Johannes , Stander Tinus
Published: April 2021

Phased array systems have become paramount to
the development of next generation wireless communication networks, with errors
on phase shifters contributing to beam pointing error. Oscillation-based built-in
self-testing (OBIST) of phase shifters may improve on this accuracy. We propose
a single-ended oscillation-based test technique for passive RF phase shifters.
The method uses a negative resistance oscillator topology, where the phase
shifter is used to capacitively load the active negative resistance circuit
resulting in a dependency between relative phase shift and output oscillation
frequency. Simulation results indicate an average sensitivity of 0.14 MHz/° of phase
shift around a nominal 617 MHz output oscillation when testing an X-band
reflection-type phase shifter, while the addition of OBT circuitry increases
the phase shifter’s mid-band insertion loss by 0.93 dB.
Memories Carved in the Wall : A 16th-Century Type of Funerary Monuments in Transylvania
Authors: Mérai Dóra
Published: April 2021

Graves for the deceased were usually cut into the floor of churches, created in churchyard cemeteries or in the newly established public cemeteries in Transylvania in the sixteenth century. Not all graves were marked with stone funerary monuments. Wooden memorials were presumably widespread, but no contemporary sources inform about these. Grave markers from the cemeteries are simple or coped headstones and coffin-shape stones, preserved for example in Cluj (Kolozsvár) and Târgu Mureş (Marosvásárhely). These gravestones display commemorative inscriptions and simple imagery. A funerary inscription recently discovered in Ocna Mureş (Marosújvár) was carved into an ashlar within the external buttress supporting the choir of the church. This stone bearing an inscription represents a specific type of funerary monument from early modern Transylvania, most examples of which are known from Cluj. The paper presents these stone memorials: who and why chose this form of commemorating the dead.
IMPROVING THE DATABASE OF TOURISM SATELLITE ACCOUNTS IN UZBEKISTAN
Authors: Mamadjanov Abrorali Ashiralievich
Published: April 2021

The article describes the specifics of the database of tourism statistics of Uzbekistan, its compliance with the recommendations of international organizations and issues of its improvement.
KEYWORDS: tourist, excursionist, tourism statistics, national accounting system, tourism satellite account (TSA), observation, survey, accommodation facilities.
Pengaruh E-Service Quality dan Perceived Value terhadap Customer Satisfaction pada Aplikasi Mobile Bukalapak
Authors: Yokiman Oswald , Iskandar Donant Alananto , Ariwibowo Prasetio
Published: April 2021

Penelitian ini bertujuan untuk mengetahui pengaruh e-service quality dan perceived value terhadap customer satisfaction. Penelitian ini merupakan penelitian dengan pendekatan kuantitatif dengan jumlah sampel sebanyak 100 responden yang merupakan pengguna Bukalapak yang sudah pernah melakukan pembelian melalui aplikasi mobile Bukalapak minimal sebanyak 2 kali, sampel ditentukan menggunakan teknik nonprobability purposive sampling. Pengukuran yang digunakan adalah kuesioner yang disebarkan melalui Google Form kepada responden. Data dianalisis dengan SPSS 25. Hasil penelitian ini menunjukkan bahwa e-service quality berpengaruh signifikan terhadap customer satisfaction dengan nilai t hitung 6,112 > t tabel 1,98, perceived value berpengaruh signifikan terhadap customer satisfaction dengan nilai t hitung 5,310 > t tabel 1,98, e-service quality dan perceived value berpengaruh signifikan terhadap customer satisfaction secara simultan dengan nilai f hitung 86,815 > f tabel 3,09.
Access Rights to Health Services for Tolotang Believers as Minority Group, Sidrap District, Indonesia
Authors: Iin Karita Sakharina  , Aidir Amin Daud  , Hamzah Halim  , Muh. Hasrul  , Wahyudi Pratama  , Sukri Palutturi  , Anif Laila Sahir
Published: April 2021

The purpose of this paper was to analyze the forms of protection and fulfillment of human rights by localgovernments against the followers of the Tolotang faith in accessing their right to health service as minoritygroup in Sidenreng Rappang District, South Sulawesi Province. The type of research used was normativelegal research using a statutory approach. The results showed that The followers of the Tolotang faith havebeen recognized by the state, and weregiven space to worship based on their beliefs. Also Tolotang faithhave recognize by the local goverment as part of the community in Sidenreng Rappang who have the sameaccess in order to get health service from any medical stuff, doctor, clinic , hospital whenever they needit.The findings of this article can provide insights into the forms of protection and fulfillment of humanrights by local governments against the followers of the Tolotang faith inin in accessing their right to healthservice as minority group in Sidenreng Rappang District, South Sulawesi Province.The followers of theTolotang faith have been recognized by the state, and weregiven space to worship based on their beliefs.Also Tolotang faith have recognize by the local goverment as part of the community in Sidenreng Rappangwho have the same access in order to get health service from any medical stuff, doctor, clinic , hospitalwhenever they need it.
Cardiac Fibrosis Attenuation by Chlorogenic Acid and Epigallocatechin-Gallate Mediated by Suppression of Galectin-3 Gene Expression and Collagen Deposition in Rat Metabolic Syndrome Model
Authors: Indah Nur Chomsy  , M. Saifur Rohman  , Mifetika Lukitasari  , Dwi Adi Nugroho  , Husnul Khotimah
Published: April 2021

Objective: Metabolic syndrome (MetS) is a set cluster of risk factors for metabolic abnormalities thatcan develop cardiovascular disease (CVD), one of that is remodeling or cardiac fibrosis. Cardiac fibrosisidentified from the high levels of the profibrotic molecule; one of them is galectin-3. Aim: This studyintended to determine the effect of combination therapy of green coffee (CGA) and green tea (EGCG) oncardiac fibrosis by raise of the galectin-3 gene expression and collagen deposition in rat cardiac tissue inthe rat metabolic syndrome model. Methods: Twenty-four male MetS rats (Sprague-Dawley) divided intotwo control groups and three groups therapy (n=5) administration of the CGA 200mg/kgbw (body weightin kilograms) and EGCG 300mg/kgbw orally. After eight weeks of treatment, rats euthanized, then mRNAexpression of galectin-3 was measured. Furthermore, collagen deposition of cardiac tissue carried out inhistology slides. Results: Research reveals that the expression of galectin-3 decreased in the metabolicsyndrome model group, which given combination therapy compared with metabolic syndrome model micethat did not receive any therapy (P=0.000). Collagen deposition in cardiac tissue also found less than inthe therapy group compared with the group not treated with both compounds (P=0.000). The correlationbetween the two parameters shows a positive association with low strength. Conclusion: This study showsthat the combination therapy of CGA and EGCG is an engaging therapeutic candidate. It expected to reducethe progression of cardiac fibrosis in metabolic syndrome
Dosage Effectiveness of the Combination Calcium Hydroxide-Propolis as an Inhibitor for Aggregatibacter actinomycetemcomitans Biofilm
Authors: Ira Widjiastuti  , Moch. Mudjiono  , Nancy Cynthia Sudiartha  , Grace Angelina Samuel  , Ni Putu Sawitri Mega
Published: April 2021

Objective: Calcium hydroxide is widely used as pulp-capping material, but it is resistant to Aggregatibacteractinomycetemcomitans bacteria. Because of this deficiency, many researchers are considering usingalternative natural ingredients, such as propolis. Propolis has been widely used in dentistry due to itsproperties and because it has active ingredients that can act as antibacterial agents. It is hoped that whencalcium hydroxide and propolis are combined, the combination can overcome the disadvantages. The aim ofthis study was to determine the dosage effectiveness of the combination calcium hydroxide-propolis as aninhibitor for A. actinomycetemcomitans biofilm. Material and methods: The sample was divided into fivegroups. The positive control group is a combination of calcium hydroxide-sterile aquadest, and the negativecontrol group is A. actinomycetemcomitans bacteria. Group I is a combination of calcium hydroxidepropolis with a ratio of 1:1, group II has a ratio of 1:1.5, and group III has a ratio of 1:2. Each group consistsof five replications. Combination of calcium hydroxide-propolis and A. actinomycetemcomitans bacterialsuspension was incubated for 2x24 hours then washed three times using PBS. Furthermore, 2% of crystalviolet was used for staining and covered with aluminum foil and then incubated for 15 minutes. Isopropanol200µL was added, followed by a measurement of OD with an ELISA reader, and the OD values werecalculated using an inhibition biofilm formula. Results: Group II has the largest mean inhibition with 76%compared to groups one and three. Conclusion: A combination of calcium hydroxide and propolis with aratio of 1: 1.5 is more effective than 1:1 or 1:2 to inhibit A. actinomycetemcomitans biofilm.
Comparison of Histological Changes in Mice Infected with the Cryptosporidium Parvum after Treatment with an Aquatic Leaf Extract of Salvia Officinalis, Pimpinella Anisum and, Spiramycin Drug
Authors: Khadiji Khleaf Al-Dulaimi  , Karama Tahreer Ahmed Al-Taee  , Thaer Abdulqader Salih
Published: April 2021

Background: Cryptosporidium parvum was cause Cryptosporidiasis .In this study the therapeutic effectof two aquatic extracts of plants in infected white mice with the C. parvum were examined and the resultswere compare with the therapeutic effect of Spiramycin through the study of the histological changes inmouse intestine. Methods: Thirty male mice were divided into six groups: group 1(non infected, negativecontrol ), group 2 (feeding with C. parvum oocysts, positive control ), group 3 (infected and treatment withleaf extract of Pimpinella anisum), group 4 (infected and treated with Salvia officinalis extract ,the group5 and 6 (infected and treatment with 5mg and 10mg Spiramycin Respectively ) The existence of oocystsin the feces of animals was counted daily during the therapeutic period .After two weeks; the changes ofcecum histological sections were examined. Conclusions: The oocysts counted in feces samples, showedsignificant differences between the treatments (P <0.05). The cecum histological changes in the group 3and 4 indicated that leaf extract of plants have moderate efficacy in treatment of C.parvum infection. Thececum appears close to normal at the concentration of 5mg Spiramycin there is no abnormal tissue in theconcentration of 10 mg.
Study of Some Biomarkers and HLA-G for Early Detection of Multiple Sclerosis Disease
Authors: Khamael Abdulla Taha  , Mayada N. Iqbal  , Gheyath Abd Ali Shalal
Published: April 2021

Multiple sclerosis is the most commonest a chronic inflammatory, demyelinating and neurodegenerativedisorder in the central nervous system (CNS) of the brain and spinal cord. The disease commonly start onsetin the age of (20-50)years, as for women, they are at greater risk of MS than men. The aim of this dissertationis to detected some biomarkers(IL-18, Caspase-1 and Opioid growth factor) in the serum and saliva inpatients with MS and study the HLA-G genotype. Moreover, the current study indicated a comparisonbetween the levels of biomarkers in two groups for MS patients (early diagnosis of MS without treatmentand with treatment group) with the group of healthy controls. This study included the total number 150case, it was classified to the group I early diagnosis without treatment (54 patients) , the group II usingtreatment (46 patients)and the group III (50) healthy controls. This study included its own questionnairestructural, where it includes the following: gender and age. Biomarkers were examined by ELISA methodsand (HLA-G) it was done by PCR,PCR Sequencing methods. The age mean +SD of the untreated groupof new early diagnosis of MS was recorded (35.54 ± 8.51) and the treated group MS (34.22 ± 8.24) while(36.5 ± 8.93) in normal population controls. This study showed the concentrations(IL-18, Caspase-1 andOGF) in the serum and saliva of MS patients for both groups comparison healthy controls. This study wasconducted using a ROC chart for patients with MS in Iraq for biomarkers for both groups. In the currentstudy investigated the effect of HLA-G 14bp polymorphism on MS. As well as, to genotype (+ 3142G>
The Covid-19 Pandemic and Developing the Legal Certainty on Bankrupcy for Health Institution in Indonesia
Authors: Krista Yitawati  , Adi Sulistiyono  , Pujiono
Published: April 2021

This research aims to analyze how to develop the legal certainty for health institution during the Covid-19pandemic period. The method used in this research is the normative research method, which analyzes therelated constitutional regulations and legal materials. In handling the impacts of the Covid-19 pandemicwhich leads to the weakening of the economy, the government has issued some economic stimuli whichare not limited to direct cash aid to the impacted people, but also relaxation and restructurization programsfor health institution and their business organs. The writer concludes that those things are not enough tocope with the bankruptcy which threatens the nation. Because of that, there needs to be restructurizationagreements between the health institution. This is because until now, the Constitution on Bankruptcy andthe Postponement of Debt Payment Obligations are the latest legislations which regulate the debtors andcreditors’ relation regarding their financial obligations during a financial crisis during the period of theCovid-19 pandemic to protect the health institution.
Impact of Active Release Technique and Core Strengthening on Pain, Muscle Stiffness, Muscle Hardness and Quality of Life on Non- Specific Low Back Pain: An Experimental Study
Authors: Laukik Vaidya  , R. K. Sinha
Published: April 2021

Background:- Bad posture while working puts excessive stress and strain on low back. These inturn contribute significantly to the development of the spasm–pain–spasm process, which ultimatelyresults in the development of myofascial trigger points(MTrPs) in the muscle fibers. This is due to thereduced blood supply that leads to a decrease in the supply of oxygen and also minerals and vitaminsto the muscle Active release technique(ART), a non-invasive soft tissue restoration procedure includesreducing the scar tissue that induces discomfort, stiffness, muscle weakness and unusual pain likemechanical dysfunction of the myofascial and soft tissue.Methodology:- This experimental study will be conducted with population of 40 aging from 18 to 25dividing them equally into two group with simple random sampling. The participants of one group will begiven active release technique with hot fomentation while the other group will receive hot fomentation. Corestrengthening exercises will be given to both the groups.Conclusion:- This study intends to find the effectiveness of active release technique in reduction of pain,muscle stiffness and muscle hardness in patients with non-specific low back pain and also the resultantimprovement in their quality of life
Ending Human Trafficking in India- A Much- Awaited Goal
Authors: Madhubrata Mohanty
Published: April 2021

Discussion on the issue of human trafficking in 21st century is definitely quite shameful as the entire worldis transformed into a small place due to globalization. Not only in India, but in almost all the countries ofthe world, this worst form of crime is still existing in some form or other. Through this paper the author hasattempted to analyze the reasons for prevalence of this crime in India even after having concerted effortsby the successive governments to completely eradicate the evil through statutory enactments. Being thesecond largest populous country of the world and having been invaded by a number of foreign invaders, thecountry always suffered in its socio-economic growth. The demographic feature of the country is certainlyanother disadvantage that makes it quite difficult for the governmental schemes to reach the poor peopleliving in the rear ends of the country. Another reason affecting the economy is the refugees coming into thecountry through its porous borders and making it their permanent shelter and expecting their shares from thelimited resources available for the countrymen. It is, in fact, a matter of grave concern that even after havingseveral enactments to deal with human trafficking, still the country is witnessing its prevalence in a largerscale. Prior to the enactment of the Indian Constitution, the Constitution makers too took it very seriouslyfor which traffic in human beings or any forms of forced labour were inserted to be prohibited under Article23. The judiciary has also taken stringent views to eradicate the crime of human trafficking through strictinterpretation of the legislative provisions. But unfortunately it is not being eradicated till today, for which itbecomes imperative for all to introspect the entire system responsible for prevalence of such crime.
Factors that Influence Self-Efficacy in Maintaining Personal Hygiene of Postpartum Mothers
Authors: Magdalena Agu Yosali  , Elpinaria Girsang  , Tisna Yant  , Siti Hanifatun Fajria
Published: April 2021

Background: At present the health status of mothers and babies in Indonesia is still low, which is markedby high maternal mortality rate (MMR) and infant mortality rate (IMR). Mothers and families must be ableto carry out their roles and functions related to postnatal maternal health care and the health of their babies.Mother’s personal hygiene helps reduce the source of infection and increases the feeling of comfort in themother and thus increase the self-efficacy of postpartum mothers to care for their babies. The purpose ofthis study is to determine the direct and indirect influence of the role of health personnel, family support,physical conditions, sources of information and social environment to self-efficacy in postpartum mothersin maintaining personal hygiene at Pasir Mulya Health Center of Bogor City in 2017.Methods: This research study used cross-sectional design. The data collection with a total sample of 60participants was taken from questionnaires. The analysis method used was the Structural Equation Model(SEM) using SmartPLS 2.0.Conclusion: The self-efficacy variable of the postpartum mother in maintaining personal hygiene at PasirMulya Health Center of Bogor City was influenced by information source (2.61%), family support (6.39%),physical condition (31.62%), information source (39.40%) and social environment (24.72%). Total directand indirect influence of self-efficacy of postpartum mother in maintaining personal hygiene was 56.44%.Thestudy showed that when the mother received more information, then the self-efficacy will be higher. If apostpartum mother has high self-efficacy, the personal hygiene will improve as well and lower the maternaland infant mortality rate.
Potassium Sorbate Induces Oxidative Stress and Genotoxicity in Human Lymphocytes
Authors: Malinee Pongsavee  , Rajnikant Mishra
Published: April 2021

Potassium sorbate, a potassium salt of sorbic acid, has been used as food preservative and antimicrobial agent.Some observations in rat and hamster cells suggest its toxicity. However, observations in human cells arelimiting. Therefore, it has been intended to investigate impacts of potassium sorbate on human lymphocytes.The lymphocytes were cultured and treated with 0.5, 1.0, 1.5 and 2.0 mg/ml of potassium sorbate for 24 and48 h. Evaluations of its impacts were done through the MTT assay, analysis of chromosomal aberrations,formation of micronucleus and activities of superoxide dismutase. The results revealed that potassiumsorbate induced oxidative stress, genotoxicity, damages to chromosome, formation of micronucleus inhuman lymphocytes.
Identifying Appropriate Therapeutic Methods in Covid-19 Originated from Persian Medicine: A Review Article
Authors: Maryam Monfared  , Mahdieh Eftekhari  , Samin Amini  , Mohammad Hasan Amini
Published: April 2021

Objectives: COVID-19, a novel Coronavirus from same family as SARS-CoV-2 is a highly contagiousvirus. It is transmitted mainly from upper respiratory system and affects important organs, like heartand lungs. The aim of this study is identifying appropriate therapeutic methods originated from persianmedicine. Materials and Methods: This study has been designed from the viewpoints of traditional andmodern medicine. Considering modern medicine, we searched valid database by searching key words“SARS-Cov-2” and “COVID-19”. For traditional medicine, we searched reliable traditional medicine likethe “Canon of Medicine” by “Avicenna”, the Exir-e Aazam and Zakhira-I Kharazm Shahi. Patients wereevaluated according to their symptoms and categorized based on traditional medicine. Physiopathologyand management of the disease, including prevention and treatment were studied. Results: The principleunderlying mechanism seems to be warm and dry dystemperament that affects different organs and causesvarious adverse effects which are higher than warm and dry dystemperament, but less than the presence ofvirus. Our traditional Iranian medicine findings are validated by the modern medicine. Conclusion: Basedon symptoms, the equivalent of this disease was examined from the viewpoint of traditional medicine.Then, physiopathology and management of this disease were presented in five levels, including one stageof prevention and four stages of treatment, and finally, the treatment recommendations of Iranian traditionalmedicine were approved with new research results.
A Study of Acute Renal Failure in the Users of Proton Pump Inhibitors
Authors: Amir M. Shumran  , Fakhir M Alzubaidy  , Faidh Y. Ahmed
Published: April 2021

Background: Proton pump inhibitors are one of the most common classes of medications that act by inhibitinggastric H+/K+ adenosine triphosphatase via covalent binding to the cysteine residues of the proton pump,they provide the most potent acid suppression available. Lansoprazole, pantoprazole, and dexlansoprazolehave the greatest bioavailability and achieve the highest plasma levels. Rabeprazole is the most acid-labilePPI and therefore the most potent, whereas pantoprazole is the least reactive and therefore the least potentPatients and methods: Research data were collected from Al-zahraa teaching hospital/ Wasit province andMorgan teaching hospital/ Babylon province, they include patients with acute renal failure who used/ usingproton pump inhibitors compared with those do not use proton pump inhibitors to know the probable relationbetween acute renal failure and the use of proton pump inhibitors. Results and discussion: Results showedthat only 30 patients of 120 patients with acute renal failure consult the hospital were PPIs users, this mayrefer to presence of a relationship between proton pump inhibitor and acute Renal failure . Previous studiesin this field referred to a similar relationship, a case reports and a recent case series implicating these drugsin acute interstitial nephritis (AIN) and progression to acute renal failure.
Microbial Infections Associated with Diabetic Foot Ulcer in Nasiriyah City
Authors: Muna F. Jahad  , Mohammed Hashim AL-Yasiri
Published: April 2021

Diabetic foot ulcers (DFUs) are a major complication of diabetes lead to development of gangrene associatedwith reduced patient quality of life, lower-extremity amputation, hospitalization, and high morbidity andmortality. This study was aimed to identify the pathogenic microorganisms in diabetic foot ulcers and to testtheir antibiotic susceptibility. A total of 134 patients with diabetic foot ulcers (DFU) attending to Diabeticcenter/ Thi-Qar province, South of Iraq were randomly selected. Samples were cultured for isolating bacteriaspecies and Fungi species. Antibiotic sensitivity testing for bacteria species was done by Kirby Bauer discdiffusion method. Elderly diabetic males were frequently observed to develop foot ulcers higher than female.The most of patients 56 (41.79%) were in the age group 51 to 60 years followed by the 36 (26.86%) patientswere in age group 41 to 50 years. Out of 162 isolates, bacteria species was 116 (71.6%) more than Fungispecies 46 (28.4%). The most isolated bacteria was Proteus mirabilis 25 (15.43%) followed by Enterobactercloacae 22 (13.58%) and both Escherichia coli and Staphylococcus epidermidis 17 (10.49%). Diabetic footinfections are life-threatening. Many pathogens associated with diabetic foot ulcers.
Comparative Evaluation of Expression of Markers of Proliferation, Angiogenesis, Apoptosis in OSMF before and after treatment with Polyherbal Preparation – Study protocol
Authors: Mrunal G. Meshram  , Vidya K. Lohe  , Rahul R. Bhowate  , Bhushan S. Madke  , Ravikant V.Sune
Published: April 2021

India alone accounts for one third of the world’s oral cancer and has a high rate of Oral Potentially MalignantDiseases (OPMD) amongst Areca Nut & Tobacco Habitual. Oral submucous fibrosis (OSMF) is one ofthe OPMDs which predominantly affect major population of South and Southeast Asia, especially Indiansubcontinent. Till date OSMF patients are treated symptomatically to relieve burning sensation, improve theopening of mouth & tongue movements, reduce blanching and relieve from roughness of oral mucosa byusing various medicinal line of treatment i.e. vitamin A, lycopene, beta carotene and carotene analogs, but notreatment is directed towards the reduction of malignant potential of preexisting OSMF cases. Thus, presentstudy will be conducted to compare the pre & post treatment serum level of proliferation, angiogenesis andapoptosis inducing expression of markers with polyherbal therapy in oral submucous fibrosis. Methods:Identification of clinically diagnosed patients of OSMF who will be divided into two groups by simplerandom sampling procedure. Group-1 patients suffering from oral submucous fibrosis, will be receivingPolyherbal Preparation while Group-2 patients receiving Lycopene. Pre and post treatment comparison forclinical signs and symptoms and serum marker expressions for Proliferation, Angiogenesis, & Apoptosis inboth groups will be done and statistically analyzed. Results: Clinical signs and symptoms will be improvedwith the present polyherbal protocol. Post treatment serum marker may favored reduction in proliferation,angiogenesis and induced apoptosis which predicts malignant transformation. Conclusions: Polyherbaltherapy will help to reduce the malignant conversion without toxic effect on other system of the human body
Fixing Blood Alkalinity by Using Apium Graveolens as Treatable Strategy to Prevent Covid 19 Likes Infection
Authors: Abdul-Samad Uleiwi Hassan  , Manal Abd Alwahed Alssirag  , Sameer Mageed Alatar
Published: April 2021

Juice of fresh celery solution will be given to domestic cats and normal cases of human to achieve thepurposes of this project. Dosages given three times a day/one weeks in a mount of one cup 250 ml for human143 lb, and cats 10 lb in amount of one spoon 15 ml for each. Later, blood O2, CO2 and alkalinity Evaluatedto get results.Our study conclusion were proves the high ability of the celery juice’s antioxidants compounds to relievethe high acidity of blood resulted from viral infections like covid 19 and influenza, in a way to curing andstrengthening the immune system against those viral infecions.
Investigation of Some Trace Elements levels Antioxidants in Patients with Thalassemia Major and Sickle Cell AnemiaThalassemia in South of Iraq
Authors: Qais R. Lahhob  , Nidhal Y. Mohammed  , Hamid J. Abbas
Published: April 2021

Back ground: Thalassemia major) THM( is the most common single gene disorder. It is a hereditary blooddisease characterized by reduced or absent production of beta globin chains. For the patients with SCA-Thal,they have two mutations (sickle cell anemia and thalassemia). The ratio of minerals and trace elements in thepatients’ blood played an important role in many biological processes. This study aims to measure the levelof seven elements, Fe, Mn, Ca+2, Mg, P, Cr, Co and three another antioxidant element (Zn, Cu &Se) in theblood of THM and SAC-thal patients.Results: In THM and SCA-Thal patients, antioxidant elements (Cu, Zn & Se), showed highly significantbehaviour when compared to each other and with the control group as total patient population, and as (total,male and female) numbers. In thalassemia patients, Fe, P & Co also showed highly significant behaviour,while Ca + 2 behaviour was not significant for male numbers only. Elemental Mg & Cr, demonstratedinsignificant behaviours. In SCA-Thal patients, Mn & Ca + 2 showed highly significant behaviour, while,Fe showed a non-significant behaviour relative to male numbers only, and Mg, P, Cr & Co showed nonsignificant behaviour.Conclusion: The study revealed the similarity of antioxidant elements behaviour in both diseases, as well asthe statistical behaviour of all elements when compared with the control group for these diseases.
Forensic Toxicology Analysis of Suicidal Hanging Deaths in Eastern Province-Saudi Arabia
Authors: Naglaa F. Mahmoud  , Maha K. Al-Mazroua  , Moustafa M.Afify  , Sahar Y. Issa
Published: April 2021

Background: Suicide is a multifaceted phenomenon with multiple underlying risk factors, including alcoholand/or abuse of other drugs and psychiatric illnesses. Toxicological analysis is of crucial importance even inhanging deaths where the cause of death seems to be ‘obvious’. Objective: To investigate hanging suicidedeaths, focusing on toxicological findings in their postmortem specimens, over a period of six years in theEastern Province, Saudi Arabia. Methods: The suicidal hanging deaths in the period from 2014 to 2019were retrospectively studied from autopsy and toxicology analysis reports. Results: Of the investigated 75hanging suicides, 64 (85.3%) were males and 11 (14.7%) were females. Most of the cases were in the agegroup between 31 and 40 years of age (36%). Non-Saudi nationals (57, 76%) much prevailed over Saudipeople (18, 24%) and the highest is the Indian population (27, 36%), followed by Saudi nationals (18, 24%).Ethanol was the commonest detected substance in the studied specimens (45, 60%). Cannabis ranked thesecond (14, 18.6%) followed by antipsychotic drugs (10, 13.3%) and amphetamine (7, 9. 3%).Conclusion:The precise statistical mortality database for hanging suicides deaths may provide a valuable evidence forthe importance of postmortem toxicology analysis and the role of alcohol and its effect on the aggressivebehavior, human health and mortality. In the current study, Ethanol was the highest detected substance in thestudied specimens (45, 60%), with predominance of non-Saudi Indian males.
Effect of Coal Particles on Embryonic Development, Egg Hatching Rate and Larvae Survival Rate of Climbing Perch Fish Anabas testudineus BLOCH
Authors: Pahmi Ansyari  , Zairin Noor  , Fatmawati  , Emmy Sri Mahredha
Published: April 2021

This study aimed to analyze the impact of coal particles on the embryo development, egg hatching rateand larvae survival rate of climbing perch fish Anabas testudineus Bloch. The research was done in the wetlaboratory of the Faculty of Fisheries and Marine, Lambung Mangkurat University for six months. Thetreatment in this study was a dose of coal particles exposure to eggs and larvae. The coal particles measuring150 ?m can penetrate the eggshell and interfere with embryo development at the stage of organ formation(organogenesis) and larval development. The eggs were exposed to coal particles 15 mg/litre of water. Itturns hatching rate was 87% lower than without exposure to 98%. Similarly, the larvae survival rate (up today 4) were exposed to coal dust 80% and without exposure to 93%.
Effect of Protecting Proteins from Degradation in the Rumen and Replacing Percentages of Treated Proteins with Blood on Biochemical Blood Parameters of Al Awassi Lambs
Authors: Ibrahim S. Jasim
Published: April 2021

The present experiment was carried out to investigate the effect of different percentages (50 and 100%)of dried whey powder and sun flower meal treated with blood or formaldehyde on Biochemical bloodparameters: Blood Glucose (BG), Blood Urea Nitrogen (BUN), Blood Cholesterol (BCH), Blood TotalProtein (BTP), Blood Albumin (ALB) and Blood Globulin (GLO) in lambs fattening diets. The resultsshowed insignificant effect in (BG), (BUN), (BCH), (BTP), (ALB) and (GLO) for dried whey powdertreated with blood or formaldehyde compared sun flower meal treated with blood or formaldehyde, and fordried whey powder treated with blood in percentages 100% compared sun flower meal treated with blood inpercentages 100%, while there was significant decrease (P < 0.05) in (BUN) and (BCH) whereas insignificanteffect in (BG), (BTP), (ALB) and (GLO) for dried whey powder treated with blood in percentages 50%compared sun flower meal treated with blood in percentages 50%.
Study of Anti-Ovarian Antibody, Anti-FSH and Anti-LH Antibodies Along with Their Receptors in Polycystic Ovarian Syndrome
Authors: Rabab Mohammed Abood  , Huda Dhaher Hathal
Published: April 2021

A case control study was conducted to compare sixty females (polycystic ovarian syndrome patients ), thirtywith high LH & FSH hormone level “Group 1 “ G1”, thirty with low LH & FSH hormone level “ Group2 “ G2 “ and thirty healthy control groups. The average age is between (15 – 45 years). The followingparameters were estimated: Luteinizing Hormone (LH), Luteinizing Hormone-Receptor (LH-R), Folliclestimulating hormone (FSH) , Follicle-stimulating hormone-Receptor (FSH-R), anti-LH ,anti-FSH , antiovarian antibody (by ELISA Technique ).Rresults showed that the average age of the patients within the first group1( G1) was 28 year, whilethe average age of the patients in the second group2( G2) was 36 years, also the results showed a highcorrelation between group1 ( G1 ) with (Anti FSH antibodies ) (93%), compared with group2 (G2) that(Anti FSH antibodies ) where it was 0% , as well a high correlation 100% between group1 (G1) with (AntiLH antibodies),compared with group2 (G2) where it was 3% . And anti-ovarian antibodies ,compared withgroup 2 .
Correlation between Salivary Cotinine Levels and Cigarette Smoking with Recurrent Aphthous Stomatitis
Authors: Raghad H Al-Ani  , Ashwak Waheeb Shaker  , Luma Musa Ibrahim
Published: April 2021

Introduction: Recurrent aphthous stomatitis (RAS) is a widespread oral mucosal disease typified by thepresence of a yellowish-grey base with high margins and flanked by an erythematous halo. RAS typicallycrops up in the lining or nonkeratinized mucosa. It has been found that smoking and salivary cotinine (ametabolic product of nicotine) levels have a protective effect against the occurrence of RAS by increasingkeratinization of the oral mucosa.Objectives: To identify the effect of smoking and nicotine level on the occurrence of RAS.Patients and Methods: the study was conducted on 92 male students studying at different Universities ofBaghdad, Iraq, in the period between January to December 2018. The students were thoroughly questionedabout the yearly recurrence rate and healing period of RAS. Data about smoking history; method, averagedaily dose, and period of the behaviour were recorded for each student. Salivary Cotinine levels weremeasured by the Human Cotinine ELISA Kit and utilising the competitive ELISA technique based on theprotocol of the manufacturer salimetrics assay #1-2002.Results: The study subjects comprised of 92 male students. Their ages were from 18 to 25 years; theaverage age was 21.04 ± 2.2. Forty-two of them were light smokers, and 50 were heavy smokers. They weresubdivided into subgroups according to the duration of smoking (less or more than five years). The annualrecurrence rates and healing period were lower in those who smoked for more than five years than those whosmoked for less than five years with a significant difference in light smokers. Salivary cotinine levels weresignificantly higher in a heavy smoker than in light smokers. Period of healing and yearly recurrence rateswere significantly lower in those who had salivary cotinine level more than 200ng/ml than in those with alevel.Conclusion: The protecting impact of smoking on RAS was solely identified when individuals were heavysmokers or smoked for longer durations of time and correlated with cotinine levels, according to the availableliterature.
Role of Ginger Ethanolic Extract in Improving Renal Dysfunction –Induced by Gentamicin
Authors: Salma Jameel Askar
Published: April 2021

Objectives: The present study was designed to evaluate the effect of ethanolic extract of ginger rhizomein improving renal dysfunction experimentally induced by gentamicin in male rats in order to give anexperimental evidence for its established use. Duration: September 2020- December 2020. Design: In thisstudy (25) Swiss albino male rats were used weighing (200-230) gm. which were divided randomly intofive equal groups, (5) rats in each group as follows: G1 (control) which was received distilled water orallydaily for 10 days. G2: received therapeutic dose of gentamicin sulphate (5mg/kg) intramuscularly oncedaily for 10 days. G3: received two fold dose of gentamicin (10mg/kg) intramuscularly once daily for 10days. G4: received co-administration of gentamicin (5mg/kg) intramuscularly + ethanolic extract of gingerrhizome (250 mg/kg) orally daily for 10 days, while the G5: received gentamicin (10mg/kg) + ethanolicextract of ginger rhizome (250mg/kg) orally daily for 10 days. All the treatments were given in amountslevels of (0.1/100gm) B.W. Animals from each group were sacrificed at the end of 10 days and blood werecollected and sera were separated for biochemical testes , while the kidneys removed for histopathologicalexaminations . The findings: Significant increase (P<0.05) in the serum levels of uric acid, creatinineand blood urea nitrogen (BUN) in (G2&G3) as compared to (G1) group , while there were significantdecrease (P<0.05) in serum levels of these testes in the groups (G4&G5) as compared to ( G2&G3 ) groupsbeside normalizing the kidney histopathological architecture . Conclusion: It can be concluded that the coadministration of gentamicin along with ginger rhizome ethanolic extract has been exhibited more activityin improving renal dysfunctions .
Formulating a Standardized Dental Record Format for Dental Surgeons in India - A Pilot Study on Dentists at Chennai and Ahmedabad
Authors: Selwin Gabriel Samuel  , M B Aswath Narayanan  , Dhwani Patel  , Vennila Anand
Published: April 2021

Background: Dental record management remains to be a much unexplored arena in forensic odontology.While some developed countries have pre-set guidelines for their licensed dental surgeons to follow, Indialacks one such protocol. As a result, majority of dental surgeons in India do not maintain patients’ recordsproperly. This not only hampers the quality of dental practice, but also compromises its potential as avaluable forensic aid.Materials and Methods: This study is a descriptive cross-sectional study. A comprehensive case historyformat was drafted for dental record management by optimizing the protocols followed by some developedcountries. The protocols were supplied to 20 dental surgeons from Chennai and Ahmedabad, who werechosen by stratified simple random sampling. The dental surgeons were asked to follow the format for amonth and give detailed feedbacks thereafter, which were collected in feedback forms.Results: Out of 25 participants, only 15 of them completed the study. The feedback contained both positiveand negative comments, along with some with effective suggestions. As a collective opinion, the dentalsurgeons felt that the case history was too exhaustive. Though the dental surgeons unreservedly welcomedmost parts of it, some dentists had difficulties in adopting certain sections in their routine practice and rathersuggested removal or modification of those divisions.Conclusion: The feedbacks and suggestions given by the dentists clarified the feasibility of the prepareddental record format. However, further research on larger scales would be helpful in arriving at definiteconclusions.
Association of Single-nucleotide Polymorphisms rs2243250 of IL4 gene in Diabetes Type 1 Patients with Acute Tonsillitis
Authors: Zainab khidhair Hussain  , Bushra Rashid Ibrahim
Published: April 2021

Diabetes mellitus type 1 one of diseases which is a difficult metabolism condition, it is characterize highlevel of glucose in of the human blood stream and is a consider prolonged autoimmune disease alignmentsever inflammatory factor. The newest studies reveal that innate immunity high role in diabetes type1. Thesamples in this study consist of (135) Iraqi male with diabetes type 1 with acute tonsillitis in three group(G1: 4-18 years, G2: 11-18 years and control) all samples diagnosed by biochemical methods added to theclinical method. Alleles were determined by amplification of the polymorphic site by real time polymerasechain reaction. The result of genotyping study of rs2243250 of IL4 revealed that the T allele frequencyshowed (0.42 %), (0.41%) and (0.69%) in groups G1,G2, control respectively, while the result revealed thatthe allele frequency C in groups G1,G2, control was (0.58%), (0.59%) and (0.31%) respectively. The studycan be concluded that the genetic variation of rs2243250 of IL4 gene was associated with diabetes mellitustype1 comparison in control (healthy women) in Iraqi men.
“I Can Teach Alone!”: Perceptions of Pre-service Teachers on Team-Teaching Practices
Authors: Hiratsuka Takaaki , Okuma Koichi
Published: April 2021

Team teaching by local Japanese teachers of English (JTEs) and foreign assistant language teachers (ALTs) has met with widespread approval and attracted great empirical attention. It is notable, however, that no study to date has explored the perceptions of pre-service teachers on team-teaching practices. The absence of such research is surprising and regrettable, considering that pre-service teachers are required under the new national foreign language curriculum to gain a deep understanding about team teaching in their teacher training courses and that they will inevitably team teach English with ALTs in their future careers. In this study, we collected data from three pre-service teachers on this subject through semi-structured interviews. From the data, three dialectics with regard to team-teaching practices were inferred: (a) encouraging/intimidating, (b) helpful/burdensome, and (c) worthwhile/unnecessary. Based on these findings, suggestions are provided for addressing these ambivalent perceptions towards team teaching in pre-service teacher training courses.
日本人英語教師(JTE)と外国語指導助手(ALT)によるティームティーチングは各方面から高く評価されている。同時に、それを題材にした様々な学術研究が行われてきた。しかし、教員養成課程学生が抱くティームティーチングへの認識に関する研究は、現在まで行われていない。その学生達が大学講義や教育実習中、更には将来正規教員としてティームティーチングに携わることを考えると、これは極めて遺憾なことである。本研究では半構造的インタビュー手法を用いて、教員養成課程学生からデータを収集した。その結果、それらの学生は(a)励み・恐れ、(b)有益・負担、(c)有意義・不必要、といった複雑な思いをティームティーチングに対して抱いていることが明らかになった。本論では最後に、教員養成課程においてティームティーチングを扱う際の留意点を提示する。