bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALISIS PEMBUATAN KONTRAK JUAL BELI ONLINE DALAM TRANSAKSI E-COMMERCE DITINJAU DARI UNDANG-UNDANG INFORMASI DAN TRANSAKSI ELEKTRONIK
Authors: Muhammad Rafi Ismail  , Agri Chairunisa Isradjuningtias
Published: January 2023

The rise of Internet and social media users in Indonesia has made e-commerce (online) business transactions grow. The increasing number of buying and selling online indirectly also has an impact on the development of the rule of law. In running an online business or conducting online transactions, there are several legal aspects of e-commerce and buying and selling online or electronically that must be known. Online transactions are usually interpreted as electronic contracts, namely legal ties or relationships that are carried out electronically which combine networks of computer-based information systems with systems. Online buying and selling was born because of a buying and selling contract that occurs electronically between the seller and the buyer. However, until now the rules of electronic buying and selling are still not clearly written in the law that applies in the territory of Indonesia. This is because the legal terms of electronic agreements have not been specifically regulated. In principle, the rules are contained in the Civil Code, which is a reference in making contracts for online buying and selling transactions. As long as this contract is made in compliance with the 4 legal terms of the agreement referred to in the Civil Code, the online transaction contract can be considered valid and binding on sellers and buyers.
PENDAFTARAN TANAH DALAM HUKUM AGRARIA LAND REGISTRATION IN AGRARIAN LAW
Authors: Ita Surayya
Published: January 2023

This study traces the shift in the legal configuration of land registration, namely the change in PP no. 10 of 1961 became PP No. 24 of 1997 concerning Land Registration by comparing the anatomy of the substance of the two government regulations. Researchers also criticize the development of regulations that encourage the acceleration of land registration in recent times. The researcher then conducted interviews with a number of agrarian activists to more deeply reveal the interests of legal ideology that caused a shift in the configuration of land registration. Changes from Government Regulation Number 10 of 1961 to Government Regulation Number 24 of 1997 concerning Land Registration are often understood only as technical changes to laws and regulations. In fact, law is not born from a vacuum so that it cannot be separated from its socio-historical context. Land registration is not only an administrative matter, but is filled with ideological-legal interests. The shift in the configuration of land registration is determined by the ideological-legal basis. In the early days of the birth of the LoGA, land registration was utilized as a land reform instrument to ensure that lands that exceeded the boundaries became objects of land redistribution. The implementation of this agrarian reform then foundered along with the change in the direction of legal ideology which was more capitalist in character so that the function of land registration turned into a land market instrument.
TUNTUTAN HAK DALAM PENEGAKAN HAK LINGKUNGAN (ENVIRONMENTAL RIGHT)
Authors: Bestian Adha  , Erwin Syahruddin
Published: January 2023

Claiming rights is a way to obtain protection for the rights of a person or legal entity granted by the court to prevent vigilante action (eigenrichhting). In his life humans choose several rights to defend including: first civil and political rights, second economic and social rights and the third is the right of solidarity or brotherhood. One type of human rights that has not been elaborated on is the right to the environment. Environmental rights are one of the rights that we need to fight for, considering that the environment cannot fight for its own interests because it is inanimate (unable to speak) so that other parties are needed to fight for it. It is necessary to expand access to justice in enforcing environmental law considering that filing rights claims in civil procedural law in Indonesia only relies on the provisions of the Het Herzeine Indonesich Reglement (HIR). such as class action, legal standing and citizen lawsuit. This paper will discuss the different characteristics of each of these rights claims in terms of environmental law enforcement. A class action lawsuit is a mechanism for filing claims for rights filed by representatives of groups fighting for their interests and their groups. An NGO lawsuit or legal standing is a mechanism for filing a lawsuit by an NGO, the lawsuit is filed if it conflicts with the articles of association of the NGO. Citizen lawsuit is a lawsuit filed by one or more citizens on behalf of all citizens addressed to the State.
KEKUATAN MENGIKAT PERJANJIAN SECARA LISAN
Authors: Juliati Br Ginting
Published: January 2023

Agreements are activities that are very commonly carried out by the community to carry out activities related to buying and selling, lending and borrowing, work agreements and other business ventures. Agreements can be made orally and can be made in writing. Oral agreements are usually carried out in indigenous peoples for simple legal ties, while written agreements are usually carried out by relatively modern people who are related to businesses whose legal relations are more complex. The problems to be discussed in this study are the binding strength of an agreement made orally. Therefore this paper also aims to determine the extent to which the binding force of the verbal agreement made by the parties. The method used in this research is the normative method, namely focusing research on legal principles and reviewing and examining written regulations. In terms of knowing the binding power of an agreement made orally. So an oral agreement is an agreement that must be carried out by the parties, because in the verbal agreement the elements of an agreement have been fulfilled. With a strong and clear legal basis, it is hoped that the parties will carry out their rights and obligations according to what has been agreed upon, so that no party feels disadvantaged.
PERLINDUNGAN HUKUM BAGI PENERIMA WASIAT TERHADAP NOTARIS YANG TIDAK MENDAFTARKAN DAN MELAPORKAN AKTA WASIAT
Authors: Sarah Patricia Rajagukguk  , Siti Hajati Hoesin
Published: January 2023

One of the powers of a Notary is to be able to make a will as mandated in the UUJN, including making a will before witnesses as regulated in Article 939 paragraph (4) of the Civil Code and making a will without witnesses as regulated in Article 939 paragraph (2) of the Civil Code. A Notary in carrying out a legal action must always act carefully so that the Notary before making a deed must examine all relevant facts in his consideration based on the applicable laws and regulations. The making of a will by a Notary must pay attention to all the provisions regulated or determined in the provisions of the legislation governing the implementation of a will. So that in the future nothing happens that can harm the parties which can then also harm the Notary who made the will. This study focuses on discussing legal protection for will recipients against notaries who do not report a will. This study uses a normative juridical method with a statutory approach and an analytical approach. Legal protection for the beneficiary against a Notary who does not report the list of deeds, namely preventive legal protection and repressive legal protection. If in the making of the will, the requirements and elements have been determined as stipulated in the Civil Code and the Law on Notary Positions, then legal protection for the beneficiary will still exist and reporting is an administrative requirement that must be met.
PENGEMUDI KENDARAAN BERMOTOR YANG MELANGGAR HUKUM YANG MENIMBULKAN KERUGIAN DAN KECELAKAAN LALU LINTAS YANG DI ATUR DALAM PASAL 1365 KUH PERDATA
Authors: Rizky Purnomo Aji  , Mas Agus Priyambodo
Published: January 2023

Road traffic problems that arise today, especially traffic violations and incidents of traffic accidents, tend to continue to increase which in turn will cause anxiety for road users. Drivers' unlawful acts cause many losses to other parties, so it is only natural that the injured party demands the driver's responsibility to compensate for the loss. This will not cause many problems if the driver is also the owner of his own motorized vehicle. However, in general, drivers of public vehicles such as public transport buses, only have the status of tenants or workers who are in a financial situation unable to pay compensation. So it is not uncommon for the fulfillment of their responsibility to pay compensation not to be commensurate with the losses that have been caused. A driver who commits an unlawful act causing a traffic accident which results in a loss to the victim must compensate for the loss that has committed an unlawful act and causes a loss, then he is obliged to compensate for that loss.
PENYELESAIAN PERSELISIHAN HUBUNGAN INDUSTRIAL DALAM PEMENUHAN HAK PEKERJA YANG DIPUTUS HUBUNGAN KERJA
Authors: Nur Febya Adhawiyah  , Imam Budi Santoso
Published: January 2023

Termination of employment is a common occurrence in the world of work, especially in the industrial sphere where there is a great need for workers, especially laborers or freelancers. Not infrequently of those who have been laid off due to several factors, especially since the Covid-19 virus in Indonesia, it is not only one or two companies that have reduced employees, but many companies have reduced employees. From here, of course, not all of them get the right and proper rights, there are some of them that do not receive their rights as they should.
ANALISA KEBERADAAN MASYARAKAT HUKUM ADAT DI INDONESIA
Authors: Santriawan Mangumpaus  , Yana Sukma Permana
Published: January 2023

The existence of Indigenous Peoples (MHA) is recognized and respected by the State through Article 18B of the 45 Constitution. therefore the government is obliged to protect the existence of indigenous peoples. However, the development of today's modern society has even negated the existence of indigenous peoples. The existence of massive population movements and land titling causes individualism to undermine the existence of indigenous and tribal peoples. Therefore, this research will answer whether the existence of MHA still needs to be protected by the government or does it have to change according to the times. Many regulations were launched to regulate MHA, which aims to protect MHA but these regulations by many observers still do not support the protection of MHA. The research method used is normative juridical research, which is a method that is carried out by examining library materials. From the various problems in the research area, it can be concluded that the existence of MHA will gradually become extinct. Article 18 B in the 1945 Constitution already implies the extinction of MHA with the clause "... as long as they are still alive and in accordance with the principles of a unitary state". Therefore the government's protection of MHA is in preparing MHA human resources to face changing times, especially the younger generation.
IMPLEMENTASI UNDANG-UNDANG NOMOR 22 TAHUN 2009 TENTANG LALU LINTAS DAN ANGKUTAN JALAN DI WILAYAH HUKUM KABUPATEN SEMARANG
Authors: Dimas Surya Guritno  , Arikha Saputra
Published: January 2023

Every motorized vehicle that is operated and/or used on the highway must meet all technical requirements and roadworthiness requirements as stipulated by Law No. 22 of 2009 concerning Road Traffic and Transportation. The objectives of this study are to: 1) examine more deeply the implementation of Law No. 22 of 2009 concerning Road Traffic and Transportation on roadworthiness tests for public transportation vehicles in the jurisdiction of Semarang Regency, 2) Knowing the obstacles related to Implementation of Law No.22 of 2009 concerning Road Traffic and Transportation on roadworthiness tests in the jurisdiction of Semarang Regency. This type of research is field research and uses a normative juridical approach in obtaining data, where a normative juridical approach is carried out based on the main legal material by examining the concepts, principles, and legal theories as well as legislation related to the Act. Law No.22 of 2009 concerning Road Traffic and Transportation in the jurisdiction of Semarang Regency. The results of this study obtained a conclusion that: The implementation of Law No. 22 of 2009 concerning Road Traffic and Transportation on roadworthiness tests for public transport vehicles is in accordance with the provisions contained in Article 54 paragraph (3) regarding KIR testing of public transport vehicles. in the jurisdiction of Semarang Regency too has been implemented using a smart card where the implementation of a smart card is a substitute for a test book which is a policy of the Central Government through the Ministry of Land Transportation program.
PERLINDUNGAN HUKUM TERHADAP KONSUMEN JASA LAYANAN PEMINJAMAN ONLINE ILLEGAL
Authors: Artha Mahendra Putra  , Rani Apriani
Published: January 2023

To be able to anticipate unwanted things and remain orderly, a legal umbrella was issued in the form of Financial Services Authority Regulation Number 77/POJK.01/2016 concerning Information Technology-Based Money-Lending Services (hereinafter abbreviated as POJK NO.77). The Financial Services Authority (hereinafter abbreviated as OJK) in this regulation has authority in terms of regulating all matters that must be complied with by companies engaged in online lending. Fintech is a technology that can facilitate technological needs that can facilitate today's financial needs1. Offering financial solutions through technology brings changes to people's lives in various forms that are tailored to their needs. This type of fintech P2P lending is widely used because the online loan process offered can be done quickly and easily. On the other hand, a number of illegal online loans have sprung up and are easily accessible to the public. Many violations of the law have been committed by illegal online loans to the detriment of society. This paper aims to find out legal protection efforts for consumers in online lending services. The research method used is normative method.
ĐẶC ĐIỂM LÂM SÀNG BỆNH NHÂN RỤNG TÓC TỪNG MẢNG TẠI BỆNH VIỆN DA LIỄU TRUNG ƯƠNG
Authors: Nguyễn Thùy Linh , Lê Hữu Doanh
Published: January 2023

Mục tiêu: Mô tả đặc điểm lâm sàng của bệnh nhân rụng tóc từng mảng (RTTM) tại Bệnh viện Da liễu Trung ương.

Đối tượng và phương pháp nghiên cứu: 110 bệnh nhân RTTM đến khám tại Bệnh viện Da liễu Trung ương từ tháng 8/2021 đến tháng 8/2022. Các bệnh nhân được khám lâm sàng, khai thác tiền sử và làm các xét nghiệm cận lâm sàng để chẩn đoán và khảo sát một số yếu tố liên quan đến bệnh RTTM. Nghiên cứu mô tả cắt ngang.

Kết quả: 110 bệnh nhân tham gia nghiên cứu có tuổi trung bình là 28,8  29, nam giới chiếm 52,7%. Thời gian mắc bệnh trung bình là 7,1 tháng. 19,1% có tiền sử RTTM, 5,5% có tiền sử gia đình bị RTTM, 32,7% có tiền sử tiêm vaccin covid, 28,2% có tiền sử vấn đề tâm lý. Chẩm là vùng tập trung nhiều tổn thương nhất 35,7%. Mức độ rụng: S1 ở 84 bệnh nhân (76,4), S2 ở 9 bệnh nhân (8,2%), S3 ở 8 bệnh nhân (7,3%), S4 ở 3 bệnh nhân (4,7%), S5 ở 6 bệnh nhân (5,5%). Kiểu hình RTTM chiếm đa số với 83,6%. Test kéo tóc dương tính 41,8%. Tổn thương móng ghi nhận ở 37,5% số bệnh nhân rụng tóc dạng dải và 25% số bệnh nhân rụng tóc toàn thể.

Kết luận: Nghiên cứu của chúng tôi cho thấy RTTM thường gặp ở lứa tuổi trẻ, hay tái phát. Vị trí rụng hay gặp ở vùng chẩm. Kiểu hình RTTM mức độ nhẹ hay gặp nhất. Tổn thương móng thường gặp ở những thể RTTM nặng.
HIỆU QUẢ ĐIỀU TRỊ BỆNH SÙI MÀO GÀ BẰNG PHỐI HỢP LASER CO2 VÀ BÔI IMIQUIMOD 5%
Authors: Trần Thị Minh Thùy , Phạm Thị Lan , Mai Bá Hoàng Anh , Phạm Đình Hòa
Published: January 2023

Mục tiêu: Đánh giá hiệu quả của Laser CO2 kết hợp với bôi Imiquimod 5% so với Laser CO2 đơn thuần trong điều trị bệnh sùi mào gà

Đối tượng và phương pháp nghiên cứu: Thử nghiệm lâm sàng có đối chứng được tiến hành trên 70 bệnh nhân sùi mào gà ở sinh dục ngoài, từ 18 tuổi trở lên. Bệnh nhân được lấy ngẫu nhiên thành hai nhóm, nhóm 1 bệnh nhân được bôi Imiquimod 5% 3 lần/tuần trong vòng 12 tuần lên vị trí sùi đã lành thương sau khi điều trị Laser CO2 1 lần nhằm loại bỏ các tổn thương sinh dục ngoài, nhóm 2 điều trị bằng laser CO2 khi có tổn thương. Đánh giá tại thời điểm trước điều trị và sau mỗi 4 tuần trong 12 tuần.

Kết quả: Sau 12 tuần điều trị, nhóm 1 có hiệu quả điều trị tốt hơn với nhóm 2: tỷ lệ khỏi  (91,2%) so với (88,9%) của nhóm 2 tuy nhiên không có sự khác biệt, P>0.05. Chúng tôi theo dõi bệnh nhân 3 tháng sau khi ngừng điều trị, nhóm 1 có 11,8% bệnh nhân xuất hiện lại tổn thương ít hơn so với nhóm 2 (33,3%), P<0.05. Việc sử dụng imiquimod 5% được dung nạp tốt. Các tác dụng phụ đáng chú ý là đau, cảm giác bỏng rát, ngứa, sưng nề, đỏ chủ yếu xảy ra nhiều ở tháng đầu và giảm dần.
3-D Printed space maintainers - A review
Authors: Afritha Noureen A , Sharanya  , Moses Joyson
Published: January 2023

Although the idea of a digital workflow is not new in dentistry, it has just recently started to be applied in pediatric dentistry. Fabrication of space maintainer is a time-consuming procedure that needs constant communication with the laboratory to be receive and provide patients the best outcomes. These devices maintain space created by premature tooth loss so that the erupting permanent teeth will not experience any kind of malocclusion As a result of clinician's natural curiosity 3-D printed space maintainer have been developed. The advanced CAD/CAM technology used for fabricating digital space maintainers improves patient experience and compliance. The current paper provides an insight on available conventional space maintainers and various aspects of technologically advanced digitainers.
Are You Ready for the Latest Data Integrity Guidance? Part 2: Computerized Systems, Outsourcing, Quality, and Regulatory Oversight
Authors: McDowall R.D.
Published: January 2023

The new PIC/S data guidance document PI-041 was published in July 2021. This column is the second part of a review looking at the expectations for computerized systems, outsourcing, regulatory actions, and remediation of data integrity failures. Spoiler alert: You won’t like this column if you use hybrid systems.
AN ANALYSIS OF ILLOCUTIONARY ACTS IN THE “SING” MOVIE
Authors: Sukmawati Darumas Bunga
Published: January 2023

Illocutionary act is one of the sub-fields studied in speech acts. Illocutionary acts can be studied in movies, one of which can be through the "Sing" movie. The movie has an interesting storyline and presents many of Buster Moon's dialogues containing illocutionary acts. The movie "Sing", which came out in 2016, was made by Illumination Entertainment. The purpose of this study was to determine the types of illocutionary acts, the most dominant type of illocutionary acts, and to explain the contribution of illocutionary acts used by Buster Moon in learning English. The data collection method was the documentation research method while the data collection technique used descriptive analysis. Researchers used descriptive qualitative research. The object of this study was the utterances of Buster Moon in the “Sing” movie. Based on Searle's theory (1979), there were five illocutionary acts used by Buster Moon, namely assertive, directive, commissive, expressive, and declarative. From these results, the writers can conclude that the directive was the most dominant illocutionary act used by Buster Moon in the "Sing" movie. Teachers can use this study as a teaching media to help their students learn more about illocutionary acts in English.
UPAYA MENINGKATKAN HASIL BELAJAR IPA DENGAN METODE DEMONSTRASI PADA SISWA KELAS VI
Authors: GUSRA SRI MAIMI
Published: January 2023

Permasalahan riset ini rendahnya hasil belajar anak didik pada kegiatan belajar mengajar IPA di kelas VI. Tujuan riset ini ialah untuk tingkatkan kegiatan serta hasil belajar anak didik dalam cara pembelajaran sehingga cara pembelajaran itu aktivitasnya tidak cuma didominasi oleh guru. Riset ini ialah riset action research. Riset ini memakai bentuk riset aksi dari Kemmis serta Taggart ialah berupa siklus yang satu ke daur yang selanjutnya. Tiap daur mencakup planning  (konsep), action (aksi), observation (observasi), serta reflection (refleksi). Instrumen yang dipakai silabus, RPP, LKS. Sebaliknya buat uji dipakai uji formatif dalam wujud pertanyaan adil. Metode analisa informasi memakai persentase ketuntasan. Pertemuan awal daur I, pertemuan kedua daur I, pertemuan awal daur II, serta pertemuan kedua daur II) ialah tiap- tiap 55%, 65%, 75%, serta 95%. Sebaliknya pada umumnya daur I 68, 5% pertemuan I, 73, 5% pertemuan II, Buat Daur II 77, 25% pertemuan I, 84, 5 pertemuan II. Aplikasi tata cara demonstrasi memiliki akibat positif, anak didik terpikat serta berkeinginan dengan tata cara demonstrasi alhasil mereka jadi termotivasi buat belajar.
Penggunaan Mobile Mental Health Apps dalam Menurunkan Caregiver Burden pada Pasien Kanker: Literature Review
Authors: Primayanthi AA Ayu Emi , Rahman La Ode Abdul
Published: January 2023

Beban perawatan pasien kanker oleh seorang caregiver sering terabaikan namun memiliki dampak psikologis yang rentannya sama dengan pasien kanker itu sendiri. Pemberian teknik psikososial terbukti mampu mengurangi stress dan kecemasan yang dialami oleh para caregiver. Pelatihan teknik manajemen stress merupakan salah satu cara untuk menangani hal tersebut. Teknik manajemen stress dapat dilakukan dan diterapkan melalui aplikasi mobile mental health apps. Tujuan dari penulisan ini adalah untuk mengetahui penggunaan Mental Health Apps dalam menurunkan caregiver burden yang dialami oleh para caregiver yang merawat pasien kanker. Metode penulisan menggunakan literature review dengan metode PRISMA yang didapatkan dari berbagai sumber database online dan terbatas dari tahun 2017-2020. Hasil dari penelusuran literature didapatkan bahwa aplikasi Mental Health Apps pada caregiver pasien kanker terbukti dapat menurunkan tingkat stress dan kecemasan yang dialami oleh caregiver selama merawat pasien kanker. Rekomendasi dari penulisan ini diharapkan kedepannya terdapat aplikasi yang memberikan layanan komprehensif kepada caregiver.
Pendampingan Legalitas Usaha Perorangan Melalui Sistem Online Single Submission pada UMKM Pelampung Pancing
Authors: Indahsari Sintia , Agustin Anisa , Helmanto Fachri
Published: January 2023

In the development of Small and Medium Enterprises (SMEs), one of the important aspects is business legality. Business legality is a form of licensing that can legalize a business entity or company so that it can be recognized by the government and the public. Implementation of community service in the form of business legal assistance to one of the fishing buoy SMEs in Cipicung Village through the Online Single Submission (OSS) system. This community service aims to increase legal awareness of MSME actors to take care of the legality of their business, as well as help MSME actors to have business license certificates. The method used to increase legal awareness is by providing assistance. Micro, Small, and Medium Enterprises as one of the actors of economic development in the regions need to be empowered through human resource development, capital support, production and productivity, business protection, partnership development, business networks and marketing as well as business legality through Online Single Submission (OSS). The results of the assistance that have been carried out for fishing buoy business actors in Cipicung Village have obtained the legality of the Micro and Small Business License (IUMK) and have been successfully issued
Chemical composition and anti-acetylcholinesterase, nitric oxide suppressing activities of Piper betle leaves oil
Authors: Nguyen Kim-Chi , Nguyen Thi Ngoc-Hiep , Nguyen Anh-Hung , Do Thi Thuy-Van
Published: January 2023

Essential oil of Piper betle leaves in Quang Nam-Da Nang do obtain via the steam distillation method with oil collection efficiency reaching 0.83%. The chemical composition of the essential oil from Piper betle leaves in Quang Nam-Da Nang is determined via the GC-MS method that includes 21 components (99.68%), among which the main components are eugenol acetate (32.33%), eugenol (24.56%), 4-allyl-1,2-diacetoxybenzene (19.8%), germacrene D (5.98%), caryophyllene (3.32%), and γ-muurolene (2.45%). The essential oil of Piper betle leaves in Quang Nam-Da Nang also showed moderate anti-acetylcholinesterase activity with IC50 (µg/mL) = 65.94±5.96 and moderate nitric oxide suppressing activity with IC50 (µg/mL) = 46.69±3.57.
THE INFLUENCE OF ENTREPRENEURSHIP EDUCATION AND E-COMMERCE BUSINESS COMMUNICATIONS PERSPECTIVE ON ENTREPRENEUR SELF EFFICACY MEDIATED INTENSITY IN STUDENTS OF THE FACULTY OF ECONOMICS AND BUSINESS UNIVERSITAS NEGERI SURABAYA
Authors: Andriani Rosi , Agus Hermawan  , Nurika Restuningdiah
Published: January 2023

The importance of this study aims to examine the effect of entrepreneurship education and the perspective of e-commerce business communication on entrepreneurial intensity mediated by entrepreneur self-efficacy in students of the economics and business faculties of Surabaya State University. This research uses a type of descriptive quantitative research with path analysis to look for relationships in each variable. The number of samples was 303 students from a total population of 1253 students from the 2019-2021 class. The research findings reveal that entrepreneurial intentions are indirectly influenced by entrepreneurship education, which means that entrepreneur self-efficacy has succeeded in mediating entrepreneurship education on the entrepreneurial intensity of students at the Faculty of Economics and Business, Universitas Negeri Surabaya. As for the e-commerce business perspective, it does not significantly influence the entrepreneurial intensity of students at the Faculty of Economics and Business Universitas Negeri Surabaya
Experiencia monoinstitucional en carcinoma de pulmón de células no pequeñas con reordenamiento EML4-ALK
Authors: Pérez Mesa Pablo , Specterman Sergio , Mocetti Esteban , Dalurzo Liliana
Published: January 2023

El gen de fusión EML4-ALK es producto de la inversión dentro del brazo corto del cromosoma 2 que da lugar a una proteína quimérica con actividad tirosinquinasa y oncogénica. EML4-ALK está presente en una pequeña proporción de pacientes con carcinoma no microcítico de pulmón (aproximadamente el 5%), principalmente en histología de adenocarcinoma y ausencia de hábito tabáquico. De 2012 a 2016 se analizó el reordenamiento EML4-ALK en 340 casos en nuestro centro. Se analizaron los pacientes con el reordenamiento por sexo, edad, hábito tabáquico, estadio diagnóstico, sitios metastásicos, respuesta al tratamiento y tiempo del mismo con inhibidores específicos. Del análisis de 340 casos, se detectó el reordenamiento EML4-ALK en 22 (6.4%), 10 de ellos de sexo masculino, edad promedio 52.4 años (23 a 86 años), 13 no tabaquistas, 13 con enfermedad metastásica al diagnóstico. De estos 22, 15 iniciaron tratamiento con crizotinib, presentando 10 de ellos beneficio clínico, con un tiempo promedio de tratamiento de 18 meses. Entre los pacientes con re arreglo cromosómico ALK, 2/22 casos presentaron concomitantemente la mutación ALK más la del gen EGFR, ambos en posición L858R del exon 21. El reordenamiento EML4-ALK es una condición infrecuente, vista generalmente en pacientes con adenocarcinoma, aunque puede presentarse en pacientes con carcinoma indiferenciado o epidermoide; en tres encontramos alteraciones del EGFR, de distinta significancia clínica. El tratamiento con inhibidores específicos es bien tolerado, con alta tasa de respuesta y beneficio clínico prolongado.
Ophthalmologists' Attitudes Towards Complementary and Alternative Medicine
Authors: Almazrou Abdulrhman A , Binyousef Faris H , Alruwaili Shahad A , Alotaibi Amani S , Alsabty Areej S , Bushnag Mawddah M , Alruwaili Thamer A
Published: January 2023

Aim: To evaluate ophthalmologists’ attitudes toward CAM and define their use and recommendations of CAM for their patients. Methods: This cross-sectional study was conducted among ophthalmologists in Saudi Arabia. A self-administered questionnaire was distributed electronically among ophthalmologists via social media. The questionnaire was pre-tested in a pilot study of 10 individuals. The questionnaire contained questions about socio-demographics and knowledge about, practices of, and attitudes toward CAM. All statistical analyses were performed using SPSS version 26. Results: A total of 102 ophthalmologists were involved in this study (68 men and 34 women). Of all the ophthalmologists, 40.2% do not ask their patients about the use of CAM, whereas only 11.8% of them ask their patients about it most of the time. Nearly 60% never recommended CAM to their patients. Most of the ophthalmologists (65.7%) think that CAM can negatively affect patients’ compliance to the conventional treatment and 61.8% felt annoyed when patients did not tell them about CAM use. When asked about their knowledge of CAM,54.9% and 37.3% indicated poor and intermediate knowledge, respectively. Most of the respondents (64.3%) were willing to take courses related to CAM, and only 3.9% of them did. Conclusion: In the time of increased use of CAM by the patients, most of the ophthalmologists demonstrated poor knowledge about CAM and do not regularly ask the patients about it. Keywords: Complementary and alternative medicine, ophthalmologist, attitudes, knowledge
Leukemia Perspective in Current Practice
Authors: Karrar Hani Raka , Nouh Mahmoud Ismail , al juman Abdulelah Abdullah awad , Almutiri Mohammed Fahad Heji , Alqudairy Lubna Khalid , Aljameeli Abdulaziz Mohammad S , Aljameeli Abdullah Mohammed S , Alabdullatif Abdulhalim Ahmed , Alsuqayh Khalifah Sulaiman , Alhuthayli Abdulaziz Khalid , Alkredees Mona Ali , Alriyaee Afyaa , Alaithan Malak Mohammed , Alshmrany Barakat Ali Jaber
Published: January 2023

Leukemia is cancer that affects the blood formation in the bone marrow, which is characterized by an increase in the number of leucocytes (leukocytosis) in the blood and bone marrow. Leukemia has four major types, which include acute myeloid leukemia (AML), acute lymphoid leukemia (ALL), chronic myeloid leukemia (CML), and chronic lymphoid leukemia (CLL). Hematopoiesis is a process in which the stem cells differentiate into erythrocytes, megakaryocytes, and immune cells of myeloid, and lymphoid, in bone marrow or lymphatic tissues. The blood is made up of fluid called plasma and three types of cells and each type has special functions. White blood cells (also called WBCs or leukocytes) help the body fight infections and other diseases. Red blood cells (also called RBCs or erythrocytes) carry oxygen from the lungs to the body’s tissues and take carbon dioxide from the tissues back to the lungs. The red blood cells give blood its color. Platelets (also called thrombocytes) help form blood clots that control bleeding. Leukemias can affect any age and the incidence is different between each type. The Clinical presentation of leukemia cells may be mature, such as in chronic myeloid leukemia, and it may come in precursor form such as in acute myeloid leukemia It can also come in two forms (precursor and mature) such as chronic myeloid leukemia. Many risk factors have been identified, such as Klinefelter, Down syndromes, ataxia telangiectasia, Bloom syndrome, Viral infections from Epstein Barr virus, Human T-lymphotropic virus, ionizing radiation exposure, radiation therapy, environmental exposure with benzene, and smoking history. There is a strong relationship between nutrition status and leukemia which strongly affect the overall survival rate. This article aims to provide a brief introduction and the signs and symptoms of leukemia, its causes, epidemiology, nutrition profile, treatment prevention and good practice management advice. Keywords: Leukemia, Acute Myeloid Leukemia, Acute Lymphoid Leukemia, Chronic Myeloid Leukemia. Chronic Lymphoid Leukemia
Capturing Provenance from Deep Learning Applications Using Keras-Prov and Colab: a Practical Approach
Authors: Pina Débora , Kunstmann Liliane , Bevilaqua Felipe , Siqueira Isabela , Lyra Alan , De Oliveira Daniel , Mattoso Marta
Published: January 2023

Due to the exploratory nature of DNNs, DL specialists often need to modify the input dataset, change a filter when preprocessing input data, or fine-tune the models’ hyperparameters, while analyzing the evolution of the training. However, the specialist may lose track of what hyperparameter configurations have been used and tuned if these data are not properly registered. Thus, these configurations must be tracked and made available for the user’s analysis. One way of doing this is to use provenance data derivation traces to help the hyperparameter’s fine-tuning by providing a global data picture with clear dependencies. Current provenance solutions present provenance data disconnected from W3C PROV recommendation, which is difficult to reproduce and compare to other provenance data. To help with these challenges, we present Keras-Prov, an extension to the Keras deep learning library to collect provenance data compliant with PROV. To show the flexibility of Keras-Prov, we extend a previous Keras-Prov demonstration paper with larger experiments using GPUs with the help of Google Colab. Despite the challenges of running a DBMS with virtual environments, DL analysis with provenance has added trust and persistence in databases and PROV serializations. Experiments show Keras-Prov data analysis, during training execution, to support hyperparameter fine-tuning decisions, favoring the comparison, and reproducibility of such DL experiments. Keras-Prov is open source and can be downloaded from https://github.com/dbpina/keras-prov.
Searching for Researchers: an Ontology-based NoSQL Database System Approach and Practical Implementation
Authors: A. Salgueiro Mariana D. , Dos Santos Veronica , C. Rêgo André L. , Guimarães Daniel S. , Santos Jefferson B. , H. Haeusler Edward , V. Villas Marcos , Lifschitz Sérgio
Published: January 2023

This work presents the design and implementation of two web-based search systems, Busc@NIMA and Quem@PUC. Both systems allow the identification of research and development projects, besides existing competencies in laboratories and departments involving professors and researchers at PUC-Rio University. Our applications are based on a list of search-related terms that are matched to the dataset composed of PUC-Rio’s Lattes CVs offered courses, information from administrative systems, and specific keywords that are input by the professors/researchers themselves. To integrate all the needed data, we consider multiple database and search technologies, such as XML, RDF, TripleStores, and Relational Databases. Search results include professor’s name, academic papers, teaching activities, contact links, keywords, and laboratories of those involved with the subject represented by the set of keywords input. We describe the main features that show how our systems work.
Jewish Social Work Biographies between Germany and Mandatory Palestine
Authors: Lau Dayana , Halpern Ayana
Published: January 2023

When social work emerged as a profession, it played a crucial role in the establishment of national welfare systems. Social movements and transnational agents – mainly women – promoted these processes. This article examines the history of social work between Germany and the Jewish community in Palestine. The focus is on the biographies of 100 Jewish social workers who emigrated from Germany to Palestine from the 1920s to the 1940s and helped establish social work in the new state.
Squamous Cell Carcinoma of Head and Neck
Authors: Bandidwattanawong Chanyoot
Published: January 2023

Squamous cell carcinoma of head and neck (SCCHN) is the most common cancer arising in the head and neck region. Smoking and heavy alcohol drinking are still the well-established causes of most cases worldwide; however, human papillomavirus (HPV) infection is the concerning cause in the Western world. The different pathogenesis, pathophysiology, and prognosis between HPV-driven and non-HPV SCCHN would lead to the different treatment approaches. Breakthroughs in radiation techniques, better organ-preserving surgical strategies, and multidisciplinary management modalities are the major reasons for the curability rate among patients with early and locally advanced SCCHN. Unfortunately, among patients with advanced, recurrent, or metastatic diseases, the treatment remains an area of need. Such patients usually die within a few years. The immune checkpoint inhibitors have been shown to provide astonishingly better survival, but only among a small and not definitely known proportion of patients. Investigating the more specific biomarkers predicting the treatment response and novel therapeutic options is warranted. In this review, we highlight the latest advances in pathophysiology, treatment, and the future direction of researches.
Knowledge of Sugar in Sugar-Sweetened Beverages in South Africa: A Survey of Postgraduate Students
Authors: Mmbengeni Victor Netshidzivhani , Mosa Selepe , John Mamokhere
Published: January 2023

This survey investigated the level of knowledge of sugar in sugar-sweetened beverages by postgraduate students enrolled at the University of Limpopo in the 2019 academic year. A survey questionnaire was sent to three hundred and fifty-nine (359) students as a target population, and two hundred and seventy-eighth (278) questionnaires were returned. The results are based on 77% of the target population. On average, the respondents correctly answered just over half of the items on added sugar in SSBs, with M = 56.02% and SD = 22.03%. There is sufficient evidence to say that the level of knowledge of added sugar between male and female University of Limpopo postgraduate students are different (t (177) = 2.763, p = .011), using the 5% level of significance. Knowledge and awareness of added sugar are not sufficient components to influence the use of nutrition labels. The findings conclude that there is a relationship between gender and knowledge of added sugar in sugar-sweetened beverages and found that no relationship exists between BMI and knowledge of added sugar in sugar-sweetened beverages. There is a need for user-friendly terminology on nutrition labels.
Characterization of Hydrogenated Amorphous Silicon Using Infrared Spectroscopy and Ellipsometry Measurements
Authors: Kassmi Mounir
Published: January 2023

We described the primary mixed compositions of hydrogenated amorphous silicon on the surface of glass (7059) in this chapter and distinguished them optically by combining the outcomes of infrared spectroscopy and ellipsometric tests. The particular hydrogen content of the aspherical voids created determines the energy level of the optical band, which ranges from 1 eV to 4 eV depending on how passivated or unpassivated the composition is. Additionally, the dielectric response is influenced by the size and proportion of the vacuum occupation relative to the surrounding phase, and each dielectric response is based on how much the implicated components have been passivated.
Predictive Control, a Strategy for Dissolved Oxygen Control in a Wastewater Treatment Plant
Authors: A. Muñoz Hernandez Jose , Eduardo Leguizamon Luis , Muñoz Hernandez Helmer
Published: January 2023

This chapter presents a strategy for controlling the concentration of dissolved oxygen (DO) in the bioreactor of a pilot wastewater plant (WWTP). The control strategy being developed is model-based predictive control (MPC). To apply the control algorithm, the estimation of the oxygen transfer function (KLa) is first performed, then the model and linearization technique are determined and finally the MBPC controller is designed. The results are simulated in MATLAB® and executed in the plant control and supervision system Supervisory Control and Data Acquisition (SCADA) in LabVIEWTM. This chapter is organized as follows: Section 1 presents a brief introduction, and Section 2 determines and describes the model to be used and its respective linearization, as well as the results obtained for the KLa parameter. Finally, Section 3 describes the design methodology of the generalized predictive control (GPC) controller proposed by Clarke, using the Model Predictive Control Toolbox and the EPSAC strategy developed by De Keyser. It should be noted that the simulations in each of the sections were performed in MATLAB® and executed in the control and supervision system with the MATLAB® script interface in LabVIEWTM.
Nutritional Values and Therapeutical Effects of Mediterranean Herbs, Spices, and Medicinal Plants
Authors: Trajkovska-Broach Anita , Trajkovska Petkoska Anka
Published: January 2023

This chapter highlights the traditional use of Mediterranean edible plants, frequently used as herbs and spices in Mediterranean cuisine, and medicinal plants, used as natural therapeutics among the people in the Mediterranean region. The high phytonutrient content and diversity of these edible and nonedible wild plants in the Mediterranean are emphasized and their folk use is reviewed. The herbs, spices, and medicinal plants are vital constituents of the Mediterranean dietary pattern and lifestyle, known as the Mediterranean diet (MD). They significantly contribute to high antioxidant and anti-inflammatory character of the diet and its health and well-being benefits.
RS Codes and Optimized Distributed RS-Coded Relay Cooperative Communications: Code Constructions and Performance Analysis
Authors: Chen Chen , Yang Fengfan
Published: January 2023

This chapter introduces the Reed-Solomon (RS) codes and the distributed RS-coded cooperative system over the Rayleigh fading channel, where the encoding and decoding procedures of the RS codes are elaborated. Besides, two optimized selection approaches, i.e., the exhaustive search approach and partial search approach, are employed in the relay to obtain a resultant code at the destination with better weight distribution. Moreover, the two joint decoding algorithms, namely naive and smart algorithms, are presented that further improve the overall average bit error rate (BER) performance of the cooperative scheme. Also, the performance analysis of the distributed RS-coded cooperative scheme is provided in detailed.
A Transpraxis Approach to Higher Education: A Case Study on Methodological Orientations
Authors: Gutiérrez-Ujaque Daniel
Published: January 2023

The critical pedagogy approach opens the door to exploring the Transpraxis Approach (TA) in Higher Education (HE) as a crucial element in promoting social justice through solving social and real problems in the immediate environment. In this study, methodological principles for TA implementation are described. During the academic year 2020–2021, a case study following a participatory action research method was conducted at the University of Lleida to demonstrate how TA can be implemented in the educational methodology of two subjects in two different academic disciplines. A total of 160 students participated: seventy-eight with a bachelor’s degree in Social Education and eighty-two with a bachelor’s degree in Industrial Engineering. The twenty-seven projects carried out cooperatively by the students were analyzed using content analysis through a system of categories. According to the research, cooperative and experiential learning between university degrees is essential to creating curricular experiences beyond disciplinary boundaries and fragmented knowledge. The paper concludes with ten methodological principles for implementing TA in HE, which present university education as an enabling, collaborative, and critical response to real problems.
Periodic Instabilities in a Specific Low-Speed Pump Working as a Turbine
Authors: Bolaños Hernan , Botero Francisco
Published: January 2023

The hydrodynamic instabilities in a turbomachine can be divided into two main groups: periodic (or quasi-periodic) and nonperiodic. And the total instability, calculated from a statistical parameter with linear characteristics, such as variance, can be defined as the sum of periodic and nonperiodic instabilities. Based on the above, the main objective of the study was to estimate the periodic instabilities in a pump operating as a turbine. For this purpose, pressure fluctuation signals from sensors installed on the turbomachine volute and spaced 135° apart were used. The signals were analyzed in the time and frequency domain to identify, initially, the periodic instabilities and their relationship with the spectral components and, subsequently, to estimate the magnitude of these instabilities as the variance of the filtered series in the spectral band related to the periodic instability. In addition, the study aims to establish the contribution of periodic instabilities to total instability.
An Analysis of Epidemic Narratives in Russian Author Mikhail Bulgakov’s “A Young Doctor’s Notebook”
Authors: Emir Badegul Can
Published: January 2023

Epidemics are significant events that deeply affect societies in every period of human history. With this feature, epidemics have been the subject of the literary work –which is always sensitive to the world realities and utilizes them in their fictions– and have taken their place in many authors’ subject spectrum. In the works of doctor writer Mikhail Bulgakov (1891-1940), who was one of these writers, you can witness the reflections of medical studies on creativity. A Young Doctor’s Notebook (1925) is one of the author’s most interesting medical stories. A doctor in this story by M. Bulgakov -who was also a medical doctor- struggles with various diseases and epidemics.
The current study conducted in the light of qualitative research methods in the example of M. Bulgakov’s work, A Young Doctor’s Notebook, seeks to communicate both a doctor’s reaction and impressions and the public’s attitude towards the epidemic through the analysis of written documents. The current paper, an example of how a literary work might act as a guide in combating the epidemic and minimizing the disease effects through the medical explanations of the story A Young Doctor’s Notebook on fictitious issues, draws attention to the fact that literary works (medical stories) might contribute to the discussions on the epidemic, especially on the axis of the doctor-patient relationship.
Blogging as a tool to enable students to write more effectively
Authors: Barua Nivedita Malini
Published: January 2023

Blogging is usually associated with the posting of informal texts, but academic blogs have also become quite popular as they facilitate the exchange of ideas in many fields of study. This paper explores the scope of blogging in making tertiary level students more aware of a few important aspects of academic writing. The two objectives of this paper were to determine whether blogging can i) enable students to understand and practice the mechanics of academic writing, and ii) motivate the learners to write longer texts. The study was a quasi-experimental research that was conducted by the researcher in the classroom. The findings indicate a significant difference in the way learners understand the mechanics of academic writing due to blogging. The findings also revealed that learners are more motivated to write longer text while blogging. This study recommends the use of blogging as a tool in order to teach academic writing at the tertiary level. However, the lack of familiarity with technology among a number of students in India is still a cause for concern.