bluuebunny/crossref_metadata_2025 huggingface dataset:
La universidad pública en la pospandemia: ¿vino nuevo en odres viejos?
Authors: Baraona Cockerell Miguel , Gómez Navarro Juan Diego , Marenco Rojas Helen , Mora Arias Jaime
Published: December 2023

What impact in the medium and long term will the Pandemic have over our contemporary Society?¿and how will public universities face the current and future challenges? The answers to these two questions imply, in our perspective, a process of pedagogical innovation and in the areas of research and academic production according to the specific mission of those university systems that do not function for profit but for the wellbeing of Society and for the benefit of national and regional Latin American interest. The Centro de Estudios Generales of the Universidad Nacional of Costa Rica for many years has been pursuing a line work in education, research, outreach, and academic production guided by the principles and purposes derived from humanist though and action in our times, and the development of interdisciplinary study of complex and hypercomplex systems following some of the epistemological notions proposed by Rolando García and Jean Piaget (1982, 2000, 2006) in series of seminal works. This brief essay will cover three main sections: 1. A basic diagnosis of the global pre and post pandemic; 2. The importance of both general situations (nonetheless, emphasizing the new phenomena of the post pandemic phase) for present work in all academic areas of public universities; 3. A sketch of new humanist and interdisciplinary guidelines to contribute to our academic activity in these turbulent times.
Una experiencia integral de aprendizaje mediante la danza: el caso de Isla Venado 2005-2015
Authors: Marenco Rojas Helen
Published: December 2023

The approach to this case allows us to place dance as a mediating factor in the learning shared with students from the National University during the university extension experience on Isla Venado carried out within the framework of the Comprehensive Development Program for Rural Rural Communities of the Gulf. from Nicoya. The involvement found in the concept of movement is exposed as the main axis of the system. Thus, two meanings of order are subtracted from its epistemic root; on the one hand, external movement and on the other, internal movement. Both actions come together behind the scenes in a dance that invites us to move towards a unique stage between sky, sun, sea and salt. This document exposes the elements necessary to demonstrate a university extension process, its achievements, interdisciplinary work and local impact.
The impact of drying conditions on the surface color changes of pine wood
Authors: Suchta Aleksandra , Barański Jacek , Vilkovská Tatiana , Klement Ivan , Vilkovský Peter
Published: December 2023

The article presents the impact of drying process and selected parameters on the color changes on the surface of pine wood (Pinus sylvestris L.). Three predetermined process conditions (modes), mild, normal, and intensive, were investigated. The experiments were conducted using a semi-industrial scale dryer designed at the Gdańsk University of Technology with a loading capacity of 0.55 m3. The drying process was applied to pine wood grown in the northern part of Pomeranian region in Poland. The specimens were selected taking into consideration the radial angle of the growth rings. During each drying mode, 25 pieces of wood with dimensions (thickness, width, length) of 0.03 m, 0.2 m, and 1.5 m, respectively, were dried. The total color change (ΔE) after drying process and color saturation (h*) before and after drying processes of the wood surface was determined using the normalized CIELAB methods. The obtained results indicated that the color change of the pine wood surface increased simultaneously with the intensification of the drying process. However, the normalized wood quality after drying under intensive drying process conditions remained within the standard limits. The application of intensive drying process conditions remarkably changes the surface color of the obtained material, while remarkably reducing the drying process duration.
Parents Role in Providing Health Care for Their Children (Analytical Study of Smoking Parents and Children)
Authors: Alosoufe Laith , Al_Shatnawi Feda’a , Abu-Shaika Hayat , Jakalat Suad
Published: December 2023

The health consequences of smoking are well-known, and yet, children continue to smoke, placing their health and well-being at risk. Parents of smoking children play a crucial role in facilitating healthcare for their children and promoting healthy habits. However, caring for smoking children can be challenging, and parents who smoke face several unique challenges when providing healthcare for their children. This study aimed to explore the challenges faced by parents of smoking children when providing healthcare for their children and to identify potential intervention strategies that can facilitate better healthcare provision. A qualitative research design was used, and semi-structured interviews were conducted with 15 parents who had smoking children. Thematic analysis was performed to identify common patterns and themes in the data. The study found that parents face several challenges when caring for their smoking children, including difficulty in communicating with their children about smoking, worry about the negative health effects of smoking, difficulty in accessing healthcare services, inadequate parental education, and limited availability of family-friendly work environments. Parents highlighted the need for multi-pronged approaches to address these challenges, including parental education programs, health promotion campaigns, policy advocacy, and the use of technology. Parental education programs can empower parents by providing them with knowledge and skills to manage and prevent smoking in their children. Health promotion campaigns can reinforce the benefits of healthy habits and promote a smoke-free environment. Policy advocacy can facilitate changes in policies and regulations to improve healthcare access and support family-friendly work environments. The use of technology, such as telemedicine, can provide parents with access to healthcare services from the comfort of their homes. In conclusion, caring for smoking children can be challenging for parents who smoke. This study highlights the need to develop tailored intervention strategies to address the challenges faced by parents and to improve healthcare provision for smoking children. The recommended intervention strategies can help parents to better manage and prevent smoking in their children and promote healthy habits, leading to improved health outcomes for smoking children. Further research is needed to evaluate the effectiveness of these intervention strategies in improving healthcare provision for smoking children.
Designing an Algorithm for Automated Analysis of Completed Tasks in a Mobile Learning System
Authors: Sultanov B. , Zufarov Z.M. , Xudayberdiyev S.A. , Tillashayxova M.A. , Samigova G.A. , Savochkin M.P.
Published: December 2023

Purpose: this abstract discusses an urgent problem in the modern education system associated with the need to adapt to rapid changes in social spheres and the economy. The main purpose of the study is to develop an adaptive mobile learning environment for higher education institutions, with an emphasis on the use of electronic (mobile) learning and information and analytical support for the educational process.

Methods: to achieve this goal, an analysis of existing research and publications in the field of educational technologies and the effectiveness of e-learning was carried out. The objectives of adaptive mobile learning technologies are formulated, including the creation of a virtual learning environment and the development of effective methods of text processing in distance learning.

Results: in the course of the study, an algorithm for an adaptive mobile learning environment system based on an autonomous analysis of completed tasks using neural networks was proposed. To ensure the reliability of the system, it is proposed to implement a task analysis service as a background process. A scheme for transferring information from mobile applications to a background analytical service has been developed, taking into account the use of the RabbitMQ queue for organizing communication between services. An algorithm for detailed analysis of the text of completed assignments of students has also been developed.

Conclusions: the study highlights the need to adapt educational systems to modern challenges and the possibility of using adaptive mobile learning technologies. The developed algorithm and system provide an effective analysis of assignments and text responses of students, which makes them relevant in the context of modern information technologies and education.
All-On-Four Concept Literature Review
Authors: Isufi Ramazan , Xhajanka Edit , Thodhorjani Anis , Hysenaj Neada , Lela Fatmir , Bara Silvana , Isufi Renato
Published: December 2023

The All-on-4 concept is a dental implant technique that provides a solution for patients who have lost or are about to lose all of their teeth in one or both jaws. This concept was developed to simplify the implant process and make it more accessible for individuals with extensive tooth loss. In the review performed in Pubmed and Cochrane Library between 2005 and 2023, Full arch implant-supported prosthesis, 4-implant full arc, osseointegration, inclined implant, total edentulism and different combinations in which some of these keywords were used together were chosen. 100 of the articles achieved from the review were evaluated with respect to the subject we examined. The inclusion criteria for articles were as follows: 1-Articles were related to the all-on-four concept. 2-Abstracts were obtained when the full texts could not be obtained. The All-on-4 concept in dental implantology offers several advantages, making it a popular and effective solution for patients with extensive tooth loss. The All-on-4 concept allows for the immediate loading of prostheses onto the implants shortly after surgery. Compared to traditional implant approaches, All-on-4 reduces treatment time significantly. The concept utilizes tilted posterior implants, which take advantage of available bone and reduce the necessity for bone grafting in areas with insufficient bone volume. All-on-4 may be more cost-effective than traditional implant-supported restorations due to the reduced number of implants and the associated surgical procedures. The concept aims to provide a fixed, full-arch prosthesis that closely resembles natural teeth. Numerous studies have reported high success rates for the All-on-4 concept, with the majority of patients experiencing successful osseointegration and long-term stability of the implants. All-on-4 often results in a more comfortable experience for patients, with fewer surgical interventions and reduced healing periods. The tilted posterior implants increase the contact between bone and implant, enhancing stability and support for the prosthesis.
Patrones de actividad de mamíferos alrededor de la línea transportadora de gas natural de Camisea en la Reserva Comunal Machiguenga, Cusco, Perú
Authors: Zegarra Orlando , Rivero Jorge , Sanchez Nadia , Hernani José , Salas Paola
Published: December 2023

En el presente trabajo se estudia la actividad horaria de los mamíferos que habitan el área circundante a la línea transportadora de gas de Camisea que atraviesa la Reserva Comunal Machiguenga. Desde febrero del 2020 hasta enero del 2021, se realizó un registro fotográfico mediante cámaras trampa dispuestas a lo largo de la tubería de gas. Los patrones de actividad se estimaron mediante la función de densidad de Kernel. Durante el periodo de estudio, se registraron 25 especies de mamíferos. Se encontró que Dasyprocta kalinowskii y Eira barbara presentan un patrón de actividad diurno; mientras que Cuniculus paca, Tapirus terrestris, Dasypus spp. y Mazama spp. presentan un patrón predominantemente nocturno. Se sugiere que los patrones de actividad observados estarían influenciados por varios factores como la exclusión competitiva entre D. kalinowskii y C. paca, disponibilidad estacional del alimento para T. terrestris, variación de temperatura y precipitación para Dasypus spp., restricciones filogenéticas en Mazama spp., y segregación temporal con otros carnívoros para E. barbara. Se destaca la importancia de la colaboración entre las empresas del rubro energético, las comunidades nativas y las organizaciones gubernamentales.
Primeros registros documentados y categorización del estado de conservación de Dressleria dodsoniana y Galeandra minax (Orchidaceae; Catasetinae) de Colombia
Authors: Rojas-P Albeiro , Tujillo Trujillo Edwin , Perdomo Oscar
Published: December 2023

Registramos la presencia de Dressleria dodsoniana y Galeandra minax en Caquetá, Colombia, basados en dos poblaciones encontradas en la vertiente oriental de la Cordillera Oriental de los Andes y en el piedemonte Andino-Amazónico, respectivamente. Estas especies han sido previamente reportadas para el país en documentos impresos y en bases de datos, pero, sin la mención de ejemplares de herbario, siendo los registros fotográficos la única evidencia para su registro. Nuestros reportes resaltan la necesidad de confirmar la identidad y ocurrencia de las especies con la inclusión de colecciones botánicas en herbarios. Categorizamos ambas especies para Colombia como Críticamente Amenazadas (CR), debido principalmente, al deterioro de su hábitat y por el conocimiento de una única población registrada.
Identificación y selección de Saccharomyces cerevisiae nativas para mejorar el proceso productivo del Pisco a partir de uva Quebranta
Authors: Almanza Cano Aybel , Cruz Hilacondo Wilbert , Cáceres Iparraguirre Hanna , Blas Sevillano Raúl Humberto
Published: December 2023

El Pisco es el destilado del Perú, elaborado a partir de mostos recientemente fermentados con uvas criollas denominadas “pisqueras”. Las levaduras son los microorganismos clave en la fermentación y el uso de cepas nativas seleccionadas presenta ventajas competitivas para la tipicidad del producto, así como también para la estandarización del producto y el control microbiológico del proceso. El objetivo fue identificar y seleccionar las cepas de levaduras nativas para la producción del Pisco de uva Quebranta aisladas de procesos productivos de Pisco en el valle de Ica. Para ello, se emplearon técnicas microbiológicas y moleculares mediante el análisis de ITS1-5.8S-ITS2 PCR-RFLP para la identidad taxonómica. La evaluación de las cepas para producir Pisco consistió en el análisis fisicoquímico y organoléptico del destilado obtenido con las cepas seleccionadas. Se evaluaron 3 aislados para la producción de Pisco identificados como Saccharomyces cerevisiae: UNA SC – 25, UNA SC – 49 y UNA SC – 54, de los cuales la cepa UNA SC-49 destacó por mostrar aptitudes enológicas diferentes a las otras cepas. Este trabajo constituye el primer registro de levaduras nativas del Perú para mostos procedentes de uva Quebranta.
Using Gibbs Sampling to Estimate the Solution of the Unpaired Learning Problem
Authors:   International Research and Training Center for Information Technologies and Systems of the NAS and MES of Ukraine, Krygin Valerii M.
Published: December 2023

The article describes unpaired learning using Monte Carlo Markov Chain on the example of a stereo vision problem. The description includes the inference of the algorithm, the application of the stochastic gradient method, and some implementation details. Multiple penalty functions are considered, and quantitative results are presented. The results of the experiments expose new insights into weights for graphical models for stereo vision problems.
Methods of Dimensions Reduction in Text Processing Algorithms
Authors:   International Research and Training Center for Information Technologies and Systems of the NAS and MES of Ukraine, Marchenko Oleksandr O. , Nasirov Еmil М. ,   International Research and Training Center for Information Technologies and Systems of the NAS and MES of Ukraine
Published: December 2023

Paper describes methods of dimensionality reduction widely used in artificial intelligence in general, and in computer linguistics in particular, such as Non-negative matrix factorization and Singular value decomposition from the point of use in methods of Latent Semantic Analysis and Method of Principal Components. Advantages and disadvantages of each method are given. The computational complexity was investigated and a comparison of performance on dense and sparse matrices of different sizes was made. It is proposed to use them to reduce the dimensionality also of multidimensional linguistic data arrays.
Data Research in Industrial Data Mining Projects in the Big Data Generation Era
Authors:   International Research and Training Center for Information Technologies and Systems of the NAS and MES of Ukraine, Oursatyev Oleksii A.
Published: December 2023

Introduction. The review material is based mainly on business intelligence (BI) solutions designed for tasks with corporate data. But all the main aspects of working with data discussed in the work are also used on data processing platforms (Data Science Platform). Many BI vendors have expanded the capabilities of their systems to perform more advanced analytics, including Data Science. They added the phrase “Data Science” to their marketing research, and the term “advanced analytics” lost some popularity in relation to corporate data. The Data Science Platform provides a comprehensive set of tools for use by advanced users who traditionally work with data. Capabilities that allow you to connect to multi-structured data across different types of storage platforms, both on-premises and in the cloud, and the infrastructure architecture of a modern BI analytics platform enable high-performance workloads, including business intelligence. It uses distributed architecture, massively parallel processing, data virtualization, in-memory computing, etc. The combination of traditional relational data processing with calculations on the well-known Apache Hadoop software infrastructure, which integrates a number of components of the Hadoop ecosystem (Apache Hive, HBase, Spark, Solr, etc.) with the necessary target functions, allows you to create a fully functional platform for storing and processing structured and non-structures data. Purpose. A review of data processing problems and an analysis of the use of world-class mathematical apparatus and tools for obtaining knowledge from information were carried out. Methods. The paper describes the use of Data Mining methods in big data processing tasks, as well as methods of business, recommendation and predictive analytics. Result. The study suggests that machine learning-enhanced master data management (MDM), data quality, data preparation, and data catalogs will converge into a single, modern Enterprise Information Management (EIM) platform applicable to most new analytics projects. The results of the analysis of the process of identifying useful data can be useful to researchers and developers of modern platforms for processing and researching data in various spheres of society. Conclusion. A review of data processing problems and an analysis of the use of world-class mathematical apparatus and tools for obtaining knowledge from information were carried out. It is shown that a high-quality solution to the problems of working with first-level data indicated in this review will be provided by data research in modern analytical platforms. Successful penetration into their essence at the level of obtaining knowledge using machine learning and artificial intelligence algorithms will make it possible to predict future results in managed objects (processes) and make informed decisions.
Knowledge Graphs and Large Language Models
Authors:   International Research and Training Center for Information Technologies and Systems of the NAS and MES of Ukraine, Dvoichenkov Danylo D.
Published: December 2023

Large Language Models(LLM) based on the Transformer architecture is nowadays one of the most widely used tool in Natural Language Processing(NLP) field. Nonetheless this approach has some limitations and flaws. In particular, these problems become crucial for the NLP-based expert systems. The LLMs may sometimes hallucinate and provide non-trustworthy responses. We will advocate the using of Knowledge Graphs for solving this problem.
Software Expert System for Choosing Cryptocurrency Forecasting Algorithms in Real-Time
Authors:   National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”, Holiachenko Anastasiia M. , Lіushenko Lesia A. ,   National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”
Published: December 2023

Introduction. Today there is a large number of cryptocurrencies in the world with their own unique characteristics. Traders and investors working in the cryptocurrency market use various software to analyze and forecast the exchange rate of cryptocurrencies. The ability to correctly and quickly make decisions using the results of cryptocurrency rate forecasting is currently defined as a key goal for traders, investors and analysts of this market. Purpose. In this article, the existing methods of analysis and forecasting of the exchange rate on cryptocurrency exchanges were considered, namely – fundamental and technical analysis, machine learning, news flow analysis, and a hybrid approach. During the study, it was demonstrated that different algorithms can have a high level of probability of predictions in a specific situation and with optimized parameters, but at the same time show much lower probability indicators with the slightest change in parameters or dynamics of the cryptocurrency exchange rate. Accordingly, a perfect method with universal parameters that will always consistently show high results in the probability of predictions does not exist. The implementation of a software automatic expert system for choosing algorithms in real-time will allow automatically choose the best algorithm for cryptocurrency forecasting based on the analysis of the effectiveness of algorithms over the last N iterations in the past. Methods. By the development of automatic expert system for choosing cryptocurrency forecasting algorithms in real-time. Results. The process of analyzing and forecasting the cryptocurrency exchange rates with an existing software expert system for choosing algorithms for cryptocurrency forecasting is considered, and the logic of the operation of such an expert system is presented. Also, ways to solve problems that may arise during the application of this system were identified and substantiated. Conclusion. The alternative approach to the analysis and forecasting of cryptocurrencies in real-time was implemented in the software expert system for choosing alghorithms, which allows stabilizing the high probability of the exchange rate forecasts on the cryptocurrency market in comparison with the use of only one method or the hybridization of several methods.
B-CELL LYMPHOID NEOPLASMS IN THE 5TH EDITION OF THE WHO CLASSIFICATION OF HEMATOLYMPHOID TUMORS (2022). 2. Mature B-cell neoplasms, plasma cell neoplasms and other diseases with paraproteins
Authors:   R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine, Philchenkov A.A. , Zavelevich M.P. ,   R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine, Abramenko I.V. ,   National Research Center for Radiation Medicine, NAMS of Ukraine, Kyiv, Ukraine, Shlapatska L.M. ,   R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine
Published: December 2023

Summary. The in-depth insight into the pathogenesis of lymphoid neoplasms requires the continuous revision of the classification of these diseases. In 2022, World Health Organization specialists prepared the regular 5th issue of the Classification of Hematolymphoid Tumors. Our previous report (Oncology 2023; 25 (2): 89–103) discussed the key milestones in the development of the modern WHO classification of the tumors of lymphoid and hematopoietic tissues, the basic provisions of the new (2022) classification of hematolymphoid tumors. Such categories as “tumor-like lesions with B-cell predominance” and “precursor B-cell neoplasms” were reviewed in detail. The second part of the report aims at listing and explaining the principal changes in the 5th issue of the classification related to the mature B-cell neoplasms, plasma cell neoplasms and other diseases with paraproteins. A particular attention is focused on the practical aspects of using the new classification for verifying B-cell lymphoid malignancies taking into account the definitive molecular-biological features of the clinicopathologically distinct entities and subtypes. The changes to the classification are the key to choosing the strategies for the therapy of the hematological malignancies allowing for the improvement of the clinical outcomes.
Comunidades sinodais
Authors: Da Silva Paiva Vinícius
Published: December 2023

Este artigo analisa o panorama das Comunidades Eclesiais Missionárias (CEMs), articulando-o com o tema da sinodalidade. Analisa-se a vocação eclesial do cristianismo a partir da perspectiva do “nós eclesial” de Heribert Mühlen. Tendo como referência as Diretrizes Gerais da Ação Evangelizadora da Igreja no Brasil 2019-2023, reflete-se sobre a analogia da “casa” como lugar de acolhimento e de relações fraternas. Em virtude da natureza missionária da Igreja, propõe-se uma evangelização personalizada e centrada na pessoa humana. Aborda-se a dinâmica do “dar-se” como ideal de convivência e a sinergia sinodal como fator decisivo para a maturidade das comunidades eclesiais. Destaca-se o perigo do clericalismo e a importância da autonomia dos leigos. Ao final, a narrativa lucana da visitação é apresentada como paradigma para a saída missionária da Igreja.
Человек и бог: формы взаимодействия в образах фразеологизмов
Authors: Мокиенко Валерий , Никитина Татьяна
Published: December 2023

В статье на материале фразеологизмов русского и других славянских языков с привлечением вен-герских фразеологических параллелей рассматривается образная составляющая концепта «Бог». Для анализа отобраны фразеологизмы, образы которых отражают взаимодействие Бога и человека. Цель статьи – показать, как в ассоциативных механизмах фраземообразования и ситуациях, отра-жаемых прототипами идиом и пословиц, реализуются общехристианские представления о миро-устройстве и национально специфические интерпретации взаимодействия человека и Бога.

Анализируются обороты, восходящие к текстам Библии и представляющие сцены земной жизни Христа, его контакты с последователями и преследователями. В народных фразеологизмах, которые также стали объектом сопоставительного анализа, метафорически переосмысляются ситуации вза-имодействия Бога и простого человека. Клишированные обращения человека к Богу как еще один вид взаимодействия человека и Бога, содержат просьбы о семейном благополучии, здоровье, удаче.

Выявлены общие идеологемы, передаваемые конфессионно маркированными фразеологизмами и паремиями славянских языков и венгерского языка. Этот материал свидетельствует о том, что Бог в народных представлениях – заботливый покровитель, помощник человека. Бог определяет судьбу человека, сроки его жизни, отдельные поступки. Бог требует соблюдения определенных мораль-но-этических норм и сурово наказывает за отступление от них.

Анализ нашего материала позволяет сделать предварительные заключения о фраземообразова-тельной активности отдельных библейских мотивов в разных лингвокультурах: страдания Христа, отречение его учеников, карающая сила Бога шире представлены в образах западнославянских фра-зеологизмов. Русские фразеологизмы с компонентом «Бог» чаще строятся на ассоциациях с благодатью, фразеологически представленное общение с Богом зачастую можно охарактеризовать как неформальное, на Бога чаще перекладывается ответственность за опрометчивые или неблаговид-ные поступки. Симбиоз языческих и христианских представлений о мироустройстве особенно ярко иллюстрируют русские и венгерские фразеологические обороты, в которых упоминаются русский бог, венгерский бог. На русском и венгерском материале показаны также механизмы десакрализа-ции слова Бог и его использования в угрозах-обсценизмах.

Особое внимание уделяется анализу народно-этимологических и профессиональных версий про-исхождения конфессионально детерминированных фразеологизмов. Подчеркивается, что резуль-таты проведенного исследования могут быть полезны при составлении лингвокультурологических словарей и словарей библеизмов.
Tangut 'ja¹ as a Constituent Question Particle
Authors: Ji Yue
Published: December 2023

The Tangut character'ja¹(#1718) is usually glossed as Chin.nuò诺 ‘(to) promise; yes’ in dictionaries. Given the fact that it does occur in rhetorical questions, this article argues that Tangut'ja¹is instead a constituent question particle and thus not restricted in rhetorical use. The conclusion is based on a detailed philological investigation, employing multilingual parallel texts where applicable. Comparisons with other Qiangic languages reveal several candidates for cognates. Nonetheless, their similarity is more likely to be an areal typological feature, rather than an etymological relation.
Atypical primary hypertrophic osteoarthropathy diagnosed with a novel SLCO2A1 gene mutation
Authors: Hoai Thu Pham , Huyen Trang Do-Thi , Linh Luu Canh , Duc Nguyen Minh
Published: December 2023

Primary hypertrophic osteoarthropathy (HOA) is a rare condition with no identifiable cause, accounting for 3%–5% of all HOA cases. It is challenging to identify incomplete primary HOA, which can be misdiagnosed as other hypertrophic periostitis diseases. At least two of the four criteria set by Borochowitz and Rimoin (1990) must be present to diagnose primary HOA. Diagnostic difficulties due to incomplete or atypical manifestations are common. We present a case of incomplete primary PHOA at Hanoi Medical University Hospital in Vietnam. A 37-year-old male presented with ankle joint pain for nearly four years. X-ray and magnetic resonance imaging showed periostitis in the tibias and fibulas, which could not exclude Camurati–Engelmann disease. Finally, gene sequencing on the Illumina MiSeq system identified a missense mutation (c.295C>T) in the solute carrier organic anion transporter family member 2A1 (SLCO2A1) gene on chromosome 3. Our case report and literature review aim to improve specialists' understanding of incomplete primary HOA and reduce the frequency of missed diagnoses.
Clinical and potentiometric examinations of adolescent patients with chronic odontogenic maxillary sinusitis in the presence of galvanic pathology in the oral cavity
Authors:   Shupyk National Healthcare University of Ukraine, Kyiv, Tymofieiev O.O. , Cherednichenko A.M. ,   Shupyk National Healthcare University of Ukraine, Kyiv
Published: December 2023

Purpose - to determine the values of potentiometric parameters in the oral cavity present between metal inclusions, as well as between metal inclusions and the mucous membrane of the alveolar ridge in adolescent patients with chronic odontogenic maxillary sinusitis in the presence of galvanic pathology in the oral cavity Materials and methods. 30 patients with chronic odontogenic maxillary which were subjected to potentiometric and general clinical examination methods. The control group consisted of 22 practically healthy people (without concomitant diseases) of the same age, but without metal inclusions in the oral cavity (amalgam fillings and metal fixed dentures) with obligatory sanitized oral cavity. All numerical data obtained during the survey were processed by mathematical method with calculation of Student's criterion. The indicators were considered reliable at p<0.05. Results. In 30 patients with chronic odontogenic maxillary sinusitis with the presence of galvanism (compensated and decompensated forms) in the oral cavity, chronic inflammation in the maxillary sinus occurred without pronounced clinical symptoms. Conclusions. In adolescent patients with chronic odontogenic maxillary sinusitis with the presence of galvanism in the oral cavity (compensated and decompensated forms), chronic inflammation in the maxillary sinus occurred without pronounced clinical symptoms. Exacerbation of the inflammatory process was rare. Among the inflammatory complications in the postoperative period, we found only gingivitis in the oral cavity. We did not observe any other inflammatory complications in the area of the postoperative soft tissues of the postoperative wounds and recurrence of inflammatory disease of the maxillary sinus. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interest was declared by the authors.
Morphological changes of the vaginal process wall of the peritoneum in the case of its obliteration disorders in children of different age groups
Authors:   National Pirogov Memorial Medical University, Vinnytsya, Ukraine, Havryliuk A.V. , Konoplitskyi V.S. ,   National Pirogov Memorial Medical University, Vinnytsya, Ukraine
Published: December 2023

According to statistical data, diseases associated with defects of the vaginal process of the peritoneum (such as inguinal hernia, conjunctive hydrocele of the testicles, cyst of the elements of the spermatic cord) continue to occupy a significant place among the pathologies detected in the children’s population. According to literary sources, such diseases and possible complications that may arise during their treatment can contribute to the development of male infertility, which, in turn, can negatively affect the reproductive health indicators of the nation. Purpose - the study of morphological changes in the wall of the vaginal process of the peritoneum with its non-obliteration to reveal the histological features of its structure depending on the age of children. Materials and methods. The study included children whose age did not exceed 7 years and who had disorders of obliteration of the vaginal process of the peritoneum in the form of inguinal hernias, hydrocele of the testicles and cysts of the elements of the spermatic cord. In the course of an operative treatment, a fragment of the wall of the vaginal process of the peritoneum was removed from such patients for the purpose of further studying its histological structure. Results. In the histological samples, muscle, fibrous and fatty elements were found in different amounts and ratios. The presence of degenerative pathohistological changes contributing to the formation of hernial defects of the inguinal canal was revealed. Also, with age, a progressive development of the processes of atrophy of muscle fibers with their vacant replacement mainly by adipose tissue was observed. Conclusions. Analyzing the conducted morphological studies of the wall of the non-obliterated vaginal process of the peritoneum in children, it should be noted that there is a direct relationship between the number of fatty elements in the tissue of the vaginal process and the age of the patient and also an inverse relationship between the number of muscle elements in the tissue of the vaginal process and the age of the child. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interest was declared by the authors.
Gastrointestinal bleeding in children: diagnosis, analysis, and structure
Authors:   Dnipro State Medical University, Ukraine, Dihtiar V.A. , Savenko M.V. ,   Dnipro State Medical University, Ukraine, Barsuk O.M. ,   Dnipro State Medical University, Ukraine, Shchudro S.O. ,   ME Regional Medical Center of Family Health, Dnipro, Ukraine, Kaminska M.O. ,   Dnipro State Medical University, Ukraine
Published: December 2023

The incidence of gastrointestinal bleeding is a significant concern among adult patients with gastrointestinal tract (GIT) disorders, as it is a leading cause of mortality. However, there is growing evidence of changes in the pattern of gastrointestinal pathologies among children, primarily attributed to an increasing number of cases related to peptic ulcer disease (PUD) and erosive processes of the GIT. Purpose - to investigate the prevalence and analyze changes in the structure of GIT diseases in children complicated by upper gastrointestinal bleeding (GIB), based on esophagogastroduodenoscopy (EGD) data. Materials and methods. Based on the clinic’s records, a total of 4,457 children underwent EGD at the Regional Medical Center of Family Health in Dnipro. Among them, 1,393 (31.25%) patients were admitted to the surgical department with suspected GIB. In 201 (14.4%) cases, EGD was performed during active bleeding to determine its origin. The utilization of EGD during the acute phase in patients with suspected GIB is considered highly effective for both diagnosing the bleeding source and initiating early-stage treatment. The data were processed using the methods of variation statistics using the Statistica v 6.1 software package. To compare the relative indicators, the Pearson Hi-quadrat test (χ2) and the two-sided Fisher’s exact test (TCF) were used. The critical level of statistical significance (p) was accepted as <0.05. Results. To conduct a comparative analysis of diagnosed cases of GIB, two groups of children with endoscopically confirmed GIB were formed: the Group I (n=125) representing the period of 2012-2013, and the Group II (n=201) - the period of 2020-2021. The results revealed an increase of 1.6 times in the number of patients with upper GIT diseases accompanied by bleeding in the Group II. Additionally, a significant rise in the frequency of GIT diseases, specifically erosive esophagitis, was observed. The number of patients with erosive esophagitis tripled in the Group II compared to the Group I. Conclusions. In recent years, there has been a notable rise in GIT diseases accompanied by upper GIB. The number of such cases increased by 1.6 times, from 125 to 201 patients. Notably, there is a pronounced increase in the incidence of erosive esophagitis, particularly among children in the early and younger age groups. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors.
Endovascular procedures at the complex management in patients with portal hypertension and variceal bleeding
Authors:   National Pirogov Memorial Medical University, Vinnytsya, Ukraine, Petrushenko V.V. , Kedyk O.O. ,   National Pirogov Memorial Medical University, Vinnytsya, Ukraine
Published: December 2023

For today, endovascular procedures, such as embolization of splenic artery, transjugular intrahepatic shunt, and retrograde transvenous obliteration with balloon occlusion are widely applied in the treatment and prophylaxis of variceal bleeding in patients with portal hypertension. Splenomegaly with the development of hypersplenism is one of complications of portal hypertension in patients with liver cirrhosis, which can negatively be influenced on clinical course. Due to that, it can be assumed that the management of hypersplenism in patients with portal hypertension with the applying of splenic artery embolization, could be improve the results of treatment of this group of patients. Purpose - to summarize the own experience of the applying of splenic artery embolization in the complex therapy in patients with portal hypertension that complicated by the variceal bleeding. Materials and methods. This study based on the results of treatment of 36 patients, in which the embolization of splenic artery was applied in the complex management (conventional treatment and endoscopic ligation of varices). The classic method of “chronic” occlusion was used for the embolization. The embolization on the level of the initial portion of the main trunk of splenic artery was performed in 30 (83.3%) of patients. Due to the anatomical peculiarities of vasculature, embolization was performed on the level of middle part of splenic artery in 6 (16.7%) of patients. The effectiveness of the treatment was evaluated by the changes of complete blood count indices and ultrasonography results. Statistical analysis was performed using the program SPSS Statistic for Windows, version 15.0 (IBM Corp., Armonk, NY, USA). Results. The middle age of patients was 55.8±1.6 years. The middle value of Child-Turcotte-Pugh criterion was 2.44±0.08, and MELD score was 16.36±0.99 value. Conclusions. The applying of splenic artery embolization that combined with conventional therapy and endoscopic ligation of varices is appropriate and justified. Embolization of the splenic artery promotes to decrease of appearance of hypersplenism in patients with the portal hypertension with positive influence on follow-up clinical course. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors.
Ureteral obstruction after endoscopic treatment of the vesicoureteral reflux in children
Authors:   SI Academician O.F. Vozianov Institute of Urology of the NAMS of Ukraine, Kyiv, Peterburgskyy V.F. , Kalishchuk O.A. ,   SI Academician O.F. Vozianov Institute of Urology of the NAMS of Ukraine, Kyiv, Klius A.L. ,   SI Academician O.F. Vozianov Institute of Urology of the NAMS of Ukraine, Kyiv
Published: December 2023

Purpose - to investigate the ureteral obstruction (UO) frequency after endoscopic injection of the vesicoureteral reflux (VUR) in children. Materials and methods. 1068 children aged 8 months -15 years were respectively reviewed after endoscopic treatment of the VUR grades 2-4. The following factors were analyzed in terms of ureteral obstruction: age, sex, reflux grade. Also the clinical manifestations were reviewed as the ureteral obstruction management types (conservative - 28 (52.8%), stenting - (26.5%), reimplantation of the ureter - 11 (20.7%) as well. Statistical analysis of the frequency of OS (categorical data) was performed using nonparametric estimation methods (χ², Fisher's exact test). A difference of p<0.05 was considered statistically significant. Results. The total incidence of ureteral obstruction was 3.44% (53/1539 ureters). There were early (41 children) and late (12 children) obstructed units. The following risk factors for developing ureteral obstruction proved to be significant: sex (males), low reflux grade. The early UO was treated mostly with watchful waiting, stenting (13 cases) and 2 cases were submitted to open surgery. In late UO ureteral reimplantation was utilized (9 cases) as well as ureteral stenting was helpful. Conclusions. UO is an infrequent but essential complication of the endoscopic VUR correction. The early UO cases are effectively treated by watchful waiting with/without empty bladder or ureteral stenting. Ureteral reimplantation seems to be the main procedure in late UO cases. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of all participating institutions. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors.
The first intravital case of diagnosis and treatment of a giant teratoma of the sacrococcygeal area, which exceeded the body weight of a newborn on 1.5 times
Authors:   Center for neonatal surgery for malformations and their rehabilitation of SI «Institute of Pediatrics, Obstetrics and Gynecology named after academician O.M. Lukyanova of the NAMS of Ukraine», Kyiv, Sliepov O.K. , Perederii O.V. ,   SI Institute of Pediatrics, Obstetrics and Gynecology named after academician O.M. Lukyanova of the NAMS of Ukraine, Kyiv, Skrypchenko N.Y. ,   SI Institute of Pediatrics of Obstetrics and Gynecology named after academician O.М. Lukyanova of the NAMS of Ukraine, Kyiv, Kotsovsky V.V. ,   SI Institute of Pediatrics of Obstetrics and Gynecology named after academician O.М. Lukyanova of the NAMS of Ukraine, Kyiv, Hladyshko O.P. ,   SI Institute of Pediatrics of Obstetrics and Gynecology named after academician O.М. Lukyanova of the NAMS of Ukraine, Kyiv, Grebinichenko G.O. ,   SI Institute of Pediatrics, Obstetrics and Gynecology named after academician O.M. Lukyanova of the NAMS of Ukraine, Kyiv
Published: December 2023

Purpose - is to analyze and present the experience of perinatal diagnosis and treatment of giant terato-dermoid tumor (TDT) of the sacrococcygeal area, which exceeded the body weight of a newborn on 1.5 times. Clinical case. The article presents a unique clinical case of a giant teratoma of the sacrococcygeal area (SCT), which exceeded the weight of a newborn child on 1.5 times. Features of perinatal support, hypoxic-ischemic damage of internal organs, and surgical intervention for giant SCT in a premature low-weight newborn child are described, which are important elements of optimizing the treatment of children with this life-threatening pathology. Conclusions. Diagnosis and treatment of giant SCT in fetuses and newborns require scientifically based perinatal support, which includes early (up to 22 weeks of gestation) prenatal diagnosis, rational pregnancy management tactics, fetal examination, delivery by caesarean section, postnatal diagnosis and early (within 1 days) emergency radical tumor removal. The research was carried out in accordance with the principles of the Helsinki Declaration. The informed consent of the patient was obtained for conducting studies. No conflict of interests was declared by the authors.
On the Application of Nanotechnologies in Veterinary and Human Orthopedics: Implantation and Prosthetics
Authors:   Volgograd State University, Dzhafarova Eleonora , Boroznin Sergey ,   Volgograd State University
Published: December 2023

The field of orthopedic implant materials has advanced greatly in recent years, with synthetic materials on the forefront of development. The use of biocompatible polymers has allowed for the creation of materials capable of reproducing anatomical structures, resorbing over time, or eliciting specific biological responses. Polyurethanes are particularly suitable for mechanical orthopedic devices, and nanotechnology has emerged as a critical component in improving orthopedic implants. Synthetic materials also allow for the modeling of implant behavior, thus increasing the likelihood of successful implantation procedures. The development of new composite coating methods that better mimic bone structure would lead to the creation of a new generation of orthopedic implants with improved implant integration and bone healing. The addition of antibiotics to nanohydroxyapatite mixtures has been shown to prevent bacterial growth, increasing the chances of successful infection treatment and reducing the risk of implant rejection. The use of spherical nanoparticles in nanohydroxyapatite synthesis allows for the creation of powders that can be formed into any desired shape, such as screws, plates, and other forms. In conclusion, synthetic materials hold the significant potential for improving orthopedic implant technology, offering a range of possibilities for reproducing anatomical structures, eliciting biological responses, and resorbing over time. The use of polyurethanes, nanotechnology, and composite coatings offers promising avenues for future development, while the addition of antibiotics to nanohydroxyapatite mixtures and the use of spherical nanoparticles in synthesis represent significant advances in the field.