bluuebunny/crossref_metadata_2025 huggingface dataset:
Trypanosoma cruzi Parasite Load Modulates the Circadian Activity Pattern of Triatoma infestans
Authors: Chacón Francisco , Muñoz-San Martín Catalina , Bacigalupo Antonella , Álvarez-Duhart Bárbara , Solís Rigoberto , Cattan Pedro E.
Published: January 2022

American trypanosomiasis is a disease caused by the flagellate protozoan Trypanosoma cruzi, which is transmitted mainly in endemic areas by blood-sucking triatomine vectors. Triatoma infestans is the most important vector in the southern cone of South America, exhibiting a nocturnal host-seeking behavior. It has been previously documented that the parasite produces changes in some triatomine species, but this is the first time that the behavior of a vector has been evaluated in relation to its parasite load. After comparing the movement events and distance traveled of infected and non-infected T. infestans, we evaluated the change produced by different T. cruzi parasite loads on its circadian locomotor activity. We observed differences between infected and non-infected triatomines, and a significant relation between the parasite load and the increase in locomotor activity of T. infestans, which was accentuated during the photophase. This could have direct implications on the transmission of T. cruzi, as the increased movement and distance traveled could enhance the contact of the vector with the host, while increasing the predation risk for the vector, which could both constitute a risk for vectorial and oral transmission to mammals.
Review on Study Methods for Reciprocally Enwrapping Surfaces
Authors: Moroşanu Georgiana Alexandra , Baroiu Nicuşor , Teodor Virgil Gabriel , Păunoiu Viorel , Oancea Nicolae
Published: January 2022

The processing of the piece surfaces involves the transformation of the blank into a piece, the defining characteristics of the surfaces (the form, dimensions, deviations, etc.), depending to a large extent on the parameters of the generated processes of the surfaces. Generating surfaces by enveloping represents a complex problem, this mode of generating being a constant concern of researchers due to its advantages. A very important issue is the cutting edge profiling of the future tool, which will generate the wanted profile of the piece. Throughout time, researchers have studied the problems of enveloping surfaces and stated theorems related to them, based on which practical solutions have been conceive to determine the generating and generated surfaces form. The paper presents an overview on study methods for reciprocally enwrapping surfaces, as well as methods for profiling tools for generating helical surfaces by the kinematic method and by the method of decomposing the helical movement. This review can represent a basis for future research articles and projects.
MacGyvered Multiproperty Materials Using Nanocarbon and Jam: A Spectroscopic, Electromagnetic, and Rheological Investigation
Authors: Cataldo Antonino , La Pietra Matteo , Zappelli Leonardo , Mencarelli Davide , Pierantoni Luca , Bellucci Stefano
Published: January 2022

As part of a biopolymer matrix, pectin was investigated to obtain an engineered jam, due to its biodegradability. Only a few examples of pectin-based nanocomposites are present in the literature, and even fewer such bionanocomposites utilize nanocarbon as a filler—mostly for use in food packaging. In the present paper, ecofriendly nanocomposites made from household reagents and displaying multiple properties are presented. In particular, the electrical behavior and viscoelastic properties of a commercial jam were modulated by loading the jam with carbon nanotubes and graphene nanoplates. A new nanocomposite class based on commercial jam was studied, estimating the percolation threshold for each filler. The electrical characterization and the rheological measurements suggest that the behavior above the percolation threshold is influenced by the different morphology—i.e., one-dimensional or two-dimensional—of the fillers. These outcomes encourage further studies on the use of household materials in producing advanced and innovative materials, in order to reduce the environmental impact of new technologies, without giving up advanced devices endowed with different physical properties.
More than Just a Brain Disorder: A Five-Point Manifesto for Psychological Care for People with Huntington’s Disease
Authors: Zarotti Nicolò , Dale Maria , Eccles Fiona J. R. , Simpson Jane
Published: January 2022

Huntington’s disease (HD) is a rare and complex condition where affected individuals, family members, caregivers, and clinicians face a number of both long-term and fluctuating challenges. The predominant biomedical framework adopted in HD to date has traditionally viewed it as a brain disorder first and foremost. As a consequence, one of the most challenging aspects of the condition—psychological difficulties and their care—is often not given the emphasis it deserves in everyday clinical practice. Here, we propose a manifesto outlining five points to address the quality, effectiveness, availability, and accessibility of psychological care in HD. These include (1) Listening to People with HD, (2) Reformulating Difficulties Psychologically, (3) Exploring New Interventions, (4) Increasing Psychological Provision, and (5) Learning from Other Conditions. As the search for a cure continues, we hope that this manifesto will create a new impetus towards refining the current approach to psychological difficulties in HD and ultimately improve the quality of life of the tens of thousands of families affected by HD worldwide.
Prognostic Genomic Tissue-Based Biomarkers in the Treatment of Localized Prostate Cancer
Authors: Ingrosso Gianluca , Alì Emanuele , Marani Simona , Saldi Simonetta , Bellavita Rita , Aristei Cynthia
Published: January 2022

In localized prostate cancer clinicopathologic variables have been used to develop prognostic nomograms quantifying the probability of locally advanced disease, of pelvic lymph node and distant metastasis at diagnosis or the probability of recurrence after radical treatment of the primary tumor. These tools although essential in daily clinical practice for the management of such a heterogeneous disease, which can be cured with a wide spectrum of treatment strategies (i.e., active surveillance, RP and radiation therapy), do not allow the precise distinction of an indolent instead of an aggressive disease. In recent years, several prognostic biomarkers have been tested, combined with the currently available clinicopathologic prognostic tools, in order to improve the decision-making process. In the following article, we reviewed the literature of the last 10 years and gave an overview report on commercially available tissue-based biomarkers and more specifically on mRNA-based gene expression classifiers. To date, these genomic tests have been widely investigated, demonstrating rigorous quality criteria including reproducibility, linearity, analytical accuracy, precision, and a positive impact in the clinical decision-making process. Albeit data published in literature, the systematic use of these tests in prostate cancer is currently not recommended due to insufficient evidence.
Participatory Landscape Design and Water Management—A Sustainable Strategy for Renovation of Vernacular Baths and Landscape Protection in Szeklerland, Romania
Authors: Fekete Albert , Herczeg Ágnes , Ge Ning Dong , Sárospataki Máté
Published: January 2022

Szeklerland is a historical-ethnic region located on the eastern border of the Carpathian Basin, in the central region of Romania. In Szeklerland, thanks to its varied topography and a network of small settlements, landscape management is still carried out using traditional methods. Szeklerland is a macro-region rich in natural resources. Among its natural treasures, the mineral water springs with healing properties are of particular importance: around 40 percent of Romania’s mineral water resources are found here. This richness in hydrogeological features is due to the fact that the post-volcanic activities in the young tertiary mountain ranges in the region still produce large quantities of carbon dioxide, which dissolves beneficial minerals from the earth. When dissolved in water, these minerals produce mineral waters that can be used to cure various types of diseases. For centuries, the medicinal properties of the mineral waters of Szeklerland have been regularly used by the local population. In addition to their consumption, small and larger vernacular baths were built in the settlements with medicinal springs, and their regular use led to the development of a traditional, local cold-water bathing culture in the region. However, the vernacular baths were destroyed in the world wars, and their traditional use was abolished by the apparatus of the 20th century communist regime, which had no respect to natural and cultural heritage. After the political change in 1989, the attention of the society turned back to tradition and values. Alongside (or as part of) nature and landscape conservation initiatives, the reinterpretation and restoration of the intangible and practical values of vernacular baths in Szeklerland also began. Over the past decades, the renovation of vernacular baths, which started as a professional–civic initiative, has grown into an independent heritage conservation programme: dozens of vernacular baths have been renovated in Szeklerland over the past twenty years with public participation initiated and led by professionals. In the course of the renovations, baths used by local communities have been rebuilt using nature- and environment-friendly techniques, materials and in a way that they are also related to the physical environment and the mythology of the region. The project has won prestigious awards both in Romania and internationally, and has become a successful and exemplary movement in landscape heritage conservation.
Assessment of Fetal Dose and Health Effect to the Fetus from Breast Cancer Radiotherapy during Pregnancy
Authors: Suwanbut Pattarakan , Liamsuwan Thiansin , Nantajit Danupon , Masa-nga Wilai , Tannanonta Chirapha
Published: January 2022

Decision for radiotherapy during the first trimester of pregnancy may occur, as patients may not realize their pregnancy at the very early stage. Since radiation dose can affect fetal development, the aim of this study was to evaluate fetal dose and associated deterministic effects and risks to the fetus from breast cancer radiotherapy of an 8-week pregnant patient. PHITS (Particle and Heavy Ion Transport code System) Monte Carlo simulation and the J-45 computational pregnancy phantom were used to simulate breast cancer radiotherapy from a 6 MV TrueBeam linear accelerator using the three dimensional-conformal radiotherapy (3D-CRT) technique with a prescribed dose to the planning target volume (PTV) of 50 Gy. Once the fetal dose was evaluated, the occurrence of the deterministic effects and risks for developing stochastic effects in the fetus were assessed using the recommendations of NCRP Report No. 174, AAPM Report No. 50, and ICRP Publication 84. The fetal dose was evaluated to be 3.37 ± 2.66 mGy, suggesting that the fetus was expected to have no additional deterministic effects, while the risks for developing cancer and malfunctions were similar to that expected from exposure to background radiation. The comparison with the other studies showed that accurate consideration of fetal position and size was important for dose determination in the fetus, especially at the early pregnancy stage when the fetus is very small.
Mechanical Properties of a 3D-Printed Wall Segment Made with an Earthen Mixture
Authors: Ferretti Elena , Moretti Massimo , Chiusoli Alberto , Naldoni Lapo , De Fabritiis Francesco , Visonà Massimo
Published: January 2022

This study provides a contribution to the research field of 3D-printed earthen buildings, focusing, for the first time, on the load-bearing capacity of these structures. The study involves the entire production and testing process of the earthen elements, from the design, to the preparation of the mixture and the 3D printing, up to the uniaxial compression test on a wall segment. The results indicate that 3D-printed earthen elements have a compressive strength of 2.32 MPa, comparable to that of rammed earth structures. The experimental data also made it possible to draw conclusions on the action of the infill, which seems to have the function of stopping the propagation of cracks. This has a positive effect on the overall behavior of 3D-printed earthen elements, since it avoids the onset of dilative behavior in the final stages of the load test and maintains ultimate load values higher than 50% of the maximum load.
Microstructure, Mechanical Properties and Corrosion Behaviors of Al–Li–Cu–Mg–Ag–Zn Alloys
Authors: Wu Mingdong , Xiao Daihong , Wang Xinkai , Huang Lanping , Liu Wensheng
Published: January 2022

Combined with microstructure characterization and properties tests, the effects of Zn contents on the mechanical properties, corrosion behaviors, and microstructural evolution of extruded Al–Li–Cu–Mg–Ag alloys were investigated. The results show that the increase in Zn contents can accelerate hardening kinetics and improve the hardness of peak-aged alloys. The Zn-added alloys present non-recrystallization characteristics combined with partially small recrystallized grains along the grain boundaries, while the T1 phase with finer dimension and higher number density could explain the constantly increasing tensile strength. In addition, increasing Zn contents led to a lower corrosion current density and a shallower maximum intergranular corrosion depth, thus improving the corrosion resistance of the alloys. Zn addition, distributed in the central layer of T1 phases, not only facilitates the precipitation of more T1 phases but also reduces the corrosion potential difference between the T1 phase and the matrix. Therefore, adding 0.57 wt.% Zn to the alloy has an excellent combination of tensile strength and corrosion resistance. The properties induced by Zn under the T8 temper (solid solution treatment + water quenching + 5% pre-strain+ isothermal aging), however, are not as apparent as the T6 temper (solid solution treatment + water quenching + isothermal aging).
A Novel Process for Manufacturing High-Friction Rings with a Closely Defined Coefficient of Static Friction (Relative Standard Deviation 3.5%) for Application in Ship Engine Components
Authors: Gora Wojciech S. , Carstensen Jesper V. , Wlodarczyk Krystian L. , Laursen Mads B. , Hansen Erica B. , Hand Duncan P.
Published: January 2022

In recent years, there has been an increased uptake for surface functionalization through the means of laser surface processing. The constant evolution of low-cost, easily automatable, and highly repeatable nanosecond fibre lasers has significantly aided this. In this paper, we present a laser surface-texturing technique to manufacture a surface with a tailored high static friction coefficient for application within driveshafts of large marine engines. The requirement in this application is not only a high friction coefficient, but a friction coefficient kept within a narrow range. This is obtained by using nanosecond-pulsed fibre lasers to generate a hexagonal pattern of craters on the surface. To provide a suitable friction coefficient, after laser processing the surface was hardened using a chromium-based hardening process, so that the textured surface would embed into its counterpart when the normal force was applied in the engine application. Using the combination of the laser texturing and surface hardening, it is possible to tailor the surface properties to achieve a static friction coefficient of ≥0.7 with ~3–4% relative standard deviation. The laser-textured and hardened parts were installed in driveshafts for ship testing. After successfully performing in 1500 h of operation, it is planned to adopt the solution into production.
Virtual Development of Process Parameters for Bulk Metallic Glass Formation in Laser-Based Powder Bed Fusion
Authors: Lindwall Johan , Lundbäck Andreas , Marattukalam Jithin James , Ericsson Anders
Published: January 2022

The development of process parameters and scanning strategies for bulk metallic glass formation during additive manufacturing is time-consuming and costly. It typically involves trials with varying settings and destructive testing to evaluate the final phase structure of the experimental samples. In this study, we present an alternative method by modelling to predict the influence of the process parameters on the crystalline phase evolution during laser-based powder bed fusion (PBF-LB). The methodology is demonstrated by performing simulations, varying the following parameters: laser power, hatch spacing and hatch length. The results are compared in terms of crystalline volume fraction, crystal number density and mean crystal radius after scanning five consecutive layers. The result from the simulation shows an identical trend for the predicted crystalline phase fraction compared to the experimental estimates. It is shown that a low laser power, large hatch spacing and long hatch lengths are beneficial for glass formation during PBF-LB. The absolute values show an offset though, over-predicted by the numerical model. The method can indicate favourable parameter settings and be a complementary tool in the development of scanning strategies and processing parameters for additive manufacturing of bulk metallic glass.
Influence of Different Device Structures on the Degradation for Trench-Gate SiC MOSFETs: Taking Avalanche Stress as an Example
Authors: Wei Zhaoxiang , Fu Hao , Yan Xiaowen , Li Sheng , Zhang Long , Wei Jiaxing , Liu Siyang , Sun Weifeng , Wu Weili , Bai Song
Published: January 2022

The variations in the degradation of electrical characteristics resulting from different device structures for trench-gate SiC metal-oxide-semiconductor field effect transistors (MOSFETs) are investigated in this work. Two types of the most advanced commercial trench products, which are the asymmetric trench SiC MOSFET and the double-trench SiC MOSFET, are chosen as the targeted devices. The discrepant degradation trends caused by the repetitive avalanche stress are monitored. For the double-trench device, the conduction characteristic improves while the gate-drain capacitance (Cgd) increases seriously. It is because positive charges are injected into the bottom gate oxide during the avalanche process, which are driven by the high oxide electronic field (Eox) and the high impact ionization rate (I.I.) there. Meanwhile, for the asymmetric trench SiC MOSFET, the I–V curve under the high gate bias condition and the Cgd remain relatively stable, while the trench bottom is well protected by the deep P+ well. However, it’s threshold voltage (Vth) decreases more obviously when compared with that of the double-trench device and the inclined channel suffers from more serious stress than the vertical channel. Positive charges are more easily injected into the inclined channel. The phenomena and the corresponding mechanisms are analyzed and proved by experiments and technology computer-aided design (TCAD) simulations.
Comparison of CO2 Separation Efficiency from Flue Gases Based on Commonly Used Methods and Materials
Authors: Ziobrowski Zenon , Rotkegel Adam
Published: January 2022

The comparison study of CO2 removal efficiency from flue gases at low pressures and temperatures is presented, based on commonly used methods and materials. Our own experimental results were compared and analyzed for different methods of CO2 removal from flue gases: absorption in a packed column, adsorption in a packed column and membrane separation on polymeric and ceramic membranes, as well as on the developed supported ionic liquid membranes (SILMs). The efficiency and competitiveness comparison of the investigated methods showed that SILMs obtained by coating of the polydimethylsiloxane (PDMS) membrane with 1-ethyl-3-methylimidazolium acetate ([Emim][Ac]) exhibit a high ideal CO2/N2 selectivity of 152, permeability of 2400 barrer and long term stability. Inexpensive and selective SILMs were prepared applying commercial membranes. Under similar experimental conditions, the absorption in aqueous Monoethanolamine (MEA) solutions is much faster than in ionic liquids (ILs), but gas and liquid flow rates in packed column sprayed with IL are limited due to the much higher viscosity and lower diffusion coefficient of IL. For CO2 adsorption on activated carbons impregnated with amine or IL, only a small improvement in the adsorption properties was achieved. The experimental research was compared with the literature data to find a feasible solution based on commercially available methods and materials.
A Combined Atomic and Molecular Probe Characterization of Aromatic Hydrocarbons via PALS and ESR: Methylbenzene
Authors: Bartoš Josef , Zgardzińska Bożena , Švajdlenková Helena , Charmas Barbara , Lukešová Miroslava , Wysogląd Konrad , Goździuk Magdalena
Published: January 2022

A combined study of one of the simplest aromatic hydrocarbons, i.e., methylbenzene (toluene) (TOL), via the annihilation of an ortho-positronium (o-Ps) probe via positron annihilation lifetime spectroscopy (PALS) and the rotation dynamics of nitroxide spin probe 2,2,6,6-tetramethyl-piperidinyl-1-oxy (TEMPO) using electron spin resonance (ESR) over a wide temperature range, 10–300 K, is reported. The o-Ps lifetime, τ3, and the relative o-Ps intensity, I3, as a function of temperature exhibit changes defining several characteristic PALS temperatures in the slowly and rapidly cooled samples. Similarly, the spectral parameter of TEMPO mobility in TOL, 2Azz‘, and its correlation time, τc, reveal several effects at a set of the characteristic ESR temperatures, which were determined and compared with the PALS results. Finally, the physical origins of the changes in free volume expansion and spin probe mobility are revealed. They are reflected in a series of the mutual coincidences between the characteristic PALS and ESR temperatures and appropriate complementary thermodynamic and dynamic techniques.
Effect of Chitosan Deacetylation on Its Affinity to Type III Collagen: A Molecular Dynamics Study
Authors: Bełdowski Piotr , Przybyłek Maciej , Sionkowska Alina , Cysewski Piotr , Gadomska Magdalena , Musiał Katarzyna , Gadomski Adam
Published: January 2022

The ability to form strong intermolecular interactions by linear glucosamine polysaccharides with collagen is strictly related to their nonlinear dynamic behavior and hence bio-lubricating features. Type III collagen plays a crucial role in tissue regeneration, and its presence in the articular cartilage affects its bio-technical features. In this study, the molecular dynamics methodology was applied to evaluate the effect of deacetylation degree on the chitosan affinity to type III collagen. The computational procedure employed docking and geometry optimizations of different chitosan structures characterized by randomly distributed deacetylated groups. The eight different degrees of deacetylation from 12.5% to 100% were taken into account. We found an increasing linear trend (R2 = 0.97) between deacetylation degree and the collagen–chitosan interaction energy. This can be explained by replacing weak hydrophobic contacts with more stable hydrogen bonds involving amino groups in N-deacetylated chitosan moieties. In this study, the properties of chitosan were compared with hyaluronic acid, which is a natural component of synovial fluid and cartilage. As we found, when the degree of deacetylation of chitosan was greater than 0.4, it exhibited a higher affinity for collagen than in the case of hyaluronic acid.
Synthesis and Properties of Nitrogen-Doped Carbon Quantum Dots Using Lactic Acid as Carbon Source
Authors: Chang Kaixin , Zhu Qianjin , Qi Liyan , Guo Mingwei , Gao Woming , Gao Qinwei
Published: January 2022

Nitrogen-doped carbon quantum dots (N-CQDs) were synthesized in a one-step hydrothermal technique utilizing L-lactic acid as that of the source of carbon and ethylenediamine as that of the source of nitrogen, and were characterized using dynamic light scattering, X-ray photoelectron spectroscopy ultraviolet-visible spectrum, Fourier-transformed infrared spectrum, high-resolution transmission electron microscopy, and fluorescence spectrum. The generated N-CQDs have a spherical structure and overall diameters ranging from 1–4 nm, and their surface comprises specific functional groups such as amino, carboxyl, and hydroxyl, resulting in greater water solubility and fluorescence. The quantum yield of N-CQDs (being 46%) is significantly higher than that of the CQDs synthesized from other biomass in literatures. Its fluorescence intensity is dependent on the excitation wavelength, and N-CQDs release blue light at 365 nm under ultraviolet light. The pH values may impact the protonation of N-CQDs surface functional groups and lead to significant fluorescence quenching of N-CQDs. Therefore, the fluorescence intensity of N-CQDs is the highest at pH 7.0, but it decreases with pH as pH values being either more than or less than pH 7.0. The N-CQDs exhibit high sensitivity to Fe3+ ions, for Fe3+ ions would decrease the fluorescence intensity of N-CQDs by 99.6%, and the influence of Fe3+ ions on N-CQDs fluorescence quenching is slightly affected by other metal ions. Moreover, the fluorescence quenching efficiency of Fe3+ ions displays an obvious linear relationship to Fe3+ concentrations in a wide range of concentrations (up to 200 µM) and with a detection limit of 1.89 µM. Therefore, the generated N-CQDs may be utilized as a robust fluorescence sensor for detecting pH and Fe3+ ions.
Novel Trends in Dental Color Match Using Different Shade Selection Methods: A Systematic Review and Meta-Analysis
Authors: Hardan Louis , Bourgi Rim , Cuevas-Suárez Carlos Enrique , Lukomska-Szymanska Monika , Monjarás-Ávila Ana Josefina , Zarow Maciej , Jakubowicz Natalia , Jorquera Gilbert , Ashi Tarek , Mancino Davide , Kharouf Naji , Haikel Youssef
Published: January 2022

Since color matching is considered a subjective procedure, accurate shade choice is often the most challenging stage of recreating the natural appearance of teeth. Furthermore, accurate determination of tooth color is imperative for the final outcome of dental restorations. The purpose of this research is to assess the accuracy of color match between diverse shade selection methods throughout a systematic review and meta-analysis. Two independent investigators (L.H. and R.B.) screened the literature in five electronic databases. Randomized controlled trials or in vitro papers studying the effect of using either digital shade selection or visual shade selection on the accuracy of color match were included. A total of 13 manuscripts comprised the meta-analysis. Color difference (ΔE) between restorations where the shade matching was performed by the conventional method was greater than those where the shade matching was performed by computerized methods (p = 0.007). According to the subgroup analysis, only the use of digital photographs for shade matching showed a reduction in the (ΔE) (p < 0.0001), while the use of a spectrophotometer has no advantages over the use of visual shade guide tabs (p = 0.57). On the other hand, global analysis showed that incorrect shade matching was higher when the conventional method using shade guide tabs was used (p < 0.001), irrespective of whether a spectrophotometer or a digital camera was used (p < 0.001). This study concluded that the use of digital photography and spectrophotometric measurements led to fewer color differences and less incorrect shade matching than conventional methods using color shade tabs.
Novel Synthesis, Characterization and Amoxicillin Release Study of pH-Sensitive Nanosilica/Poly(acrylic acid) Macroporous Hydrogel with High Swelling
Authors: Sorkhabi Tannaz Soltanolzakerin , Samberan Mehrab Fallahi , Ostrowski Krzysztof Adam , Majka Tomasz M.
Published: January 2022

The effect of SiO2 nanoparticles on the formation of PAA (poly acrylic acid) gel structure was investigated with seeded emulsion polymerization method used to prepare SiO2/PAA nanoparticles. The morphologies of the nanocomposite nanoparticles were studied by transmission electron microscopy (TEM). Fourier-transform infrared (FTIR) spectroscopy results indicated that the PAA was chemically bonded to the surface of the SiO2 nanoparticles. Additionally, the resulting morphology of the nanocomposite nanoparticles confirmed the co-crosslinking role of the SiO2 nanoparticles in the formation of the 3D structure and hydrogel of PAA. SiO2/PAA nanocomposite hydrogels were synthesized by in situ solution polymerization with and without toluene. The morphology studies by field emission scanning electron microscopy (FESEM) showed that when the toluene was used as a pore forming agent in the polymerization process, a macroporous hydrogel structure was achieved. The pH-sensitive swelling behaviors of the nanocomposite hydrogels showed that the formation of pores in the gels structure was a dominant factor on the water absorption capacity. In the current research the absorption capacity was changed from about 500 to 4000 g water/g dry hydrogel. Finally, the macroporous nanocomposite hydrogel sample was tested as an amoxicillin release system in buffer solutions with pHs of 3, 7.2, and 9 at 37 °C. The results showed that the percentage cumulative release of amoxicillin from the hydrogels was higher in neutral and basic mediums than in the acidic medium and the amoxicillin release rate was decreased with increasing pH. Additionally, the release results were very similar to swelling results and hence amoxicillin release was a swelling controlled-release system.
Effect of Strain Rate Sensitivity on Fracture of Laminated Rings under Dynamic Compressive Loading
Authors: Partovi Amir , Shahzamanian Mohammad Mehdi , Wu Peidong
Published: January 2022

The effects of cladding layers of rate-sensitive materials on the ductility and fracture strain of compressed rings are numerically investigated by using the finite element method (FEM) and employing the Johnson–Cook (J–C) model. The results show that ductility is governed by the behavior of the material that is located at the ring outer wall regardless of the volume fraction of the core and clad materials. However, as the number of layers increases, this influence becomes less noticeable. Moreover, as barreling increases at the outer wall and decreases at the inner wall, fracture strain increases. Furthermore, the effects of ring shape factor and bonding type of clad and core materials are numerically evaluated. The numerical results show that less force per unit volume is required to fracture narrower rings and that using a noise diffusion pattern at the interface of the materials is more suitable to simulate crack propagation in the compressed rings and functionally graded materials (FGMs). Additionally, delamination has a direct relation to layer thickness and can occur even in the presence of perfect bonding conditions owing to differences among the material and fracture parameters of laminated layers.
A Two-Step Approach to Tune the Micro and Nanoscale Morphology of Porous Niobium Oxide to Promote Osteointegration
Authors: Canepa Paolo , Firpo Giuseppe , Gatta Elena , Spotorno Roberto , Giannoni Paolo , Quarto Rodolfo , Canepa Maurizio , Cavalleri Ornella
Published: January 2022

We present a two-step surface modification process to tailor the micro and nano morphology of niobium oxide layers. Niobium was firstly anodized in spark regime in a Ca- and P-containing solution and subsequently treated by acid etching. The effects of anodizing time and applied potential on the surface morphology is investigated with SEM and AFM, complemented by XPS compositional analysis. Anodizing with a limiting potential of 250 V results in the fast growth of oxide layers with a homogeneous distribution of micro-sized pores. Cracks are, however, observed on 250 V grown layers. Limiting the anodizing potential to 200 V slows down the oxide growth, increasing the anodizing time needed to achieve a uniform pore coverage but produces fracture-free oxide layers. The surface nano morphology is further tuned by a subsequent acid etching process that leads to the formation of nano-sized pits on the anodically grown oxide surface. In vitro tests show that the etching-induced nanostructure effectively promotes cell adhesion and spreading onto the niobium oxide surface.
Modeling of Bimodular Bone Specimen under Four-Point Bending Fatigue Loading
Authors: Yan Yufan , Meng Xianjia , Qu Chuanyong
Published: January 2022

The fatigue damage behavior of bone has attracted significant attention in both the mechanical and orthopedic fields. However, due to the complex and hierarchical structure of bone, describing the damage process quantitively or qualitatively is still a significant challenge for researchers in this area. In this study, a nonlinear bi-modulus gradient model was proposed to quantify the neutral axis skewing under fatigue load in a four-point bending test. The digital image correlation technique was used to analyze the tensile and compressive strains during the fatigue process. The results showed that the compressive strain demonstrated an obvious two-stage ascending behavior, whereas the tensile strain revealed a slow upward progression during the fatigue process. Subsequently, a theoretical model was proposed to describe the degradation process of the elastic modulus and the movement of the neutral axis. The changes in the bone properties were determined using the FEM method based on the newly developed model. The results obtained from two different methods exhibited a good degree of consistency. The results obtained in this study are of help in terms of effectively exploring the damage evolution of the bone materials.
Real Time SPR Assessment of the Structural Changes of Adaptive Dynamic Constitutional Frameworks as a New Route for Sensing
Authors: David Sorin , Gheorghiu Mihaela , Daakour Sanaa , Munteanu Raluca-Elena , Polonschii Cristina , Gáspár Szilveszter , Barboiu Mihail , Gheorghiu Eugen
Published: January 2022

Cross linked gold-dynamic constitutional frameworks (DCFs) are functional materials of potential relevance for biosensing applications, given their adaptivity and high responsivity against various external stimuli (such as pH, temperature) or specific interactions with biomolecules (enzymes or DNA) via internal constitutional dynamics. However, characterization and assessment of their dynamic conformational changes in response to external stimuli has never been reported. This study proves the capability of Surface Plasmon Resonance (SPR) assays to analyse the adaptive structural modulation of a functional matrix encompassing 3D gold-dynamic constitutional frameworks (Au-DCFs) when exposed to pH variations, as external stimuli. We analyse Au-DCFs formed from Au nanoparticles, (AuNP) connected through constitutionally dynamic polymers, dynamers, with multiple functionalities. For increased generality of this proof-of-concept assay, Au-DCFs, involving DCFs designed from 1,3,5-benzene-tricarbaldehyde (BTA) connecting centres and polyethylene glycol (PEG) connectors, are covalently attached to standard SPR sensing chips (Au nanolayers, carboxyl terminated or with carboxymethyl dextran, CMD top-layer) and analysed using state-of-the art SPR instrumentation. The SPR effects of the distance from the Au-DCFs matrix to the Au nanolayer of the sensing chip, as well as of Au-DCFs thickness were investigated. This study reveals the SPR response, augmented by the AuNP, to the conformational change, i.e., shrinkage, of the dynamer and AuNP matrix when decreasing the pH, and provides an unexplored insight into the sensing applicability of SPR real-time analysis of adaptive functional materials.
Density Functional Theory Study of B, N, and Si Doped Penta-Graphene as the Potential Gas Sensors for NH3 Detection
Authors: Chen Guangjun , Gan Lei , Xiong Huihui , Zhang Haihui
Published: January 2022

Designing a high-performance gas sensor to efficiently detect the hazardous NH3 molecule is beneficial to air monitoring and pollution control. In this work, the first-principles calculations were employed to investigate the adsorption structures, electronic characteristics, and gas sensing properties of the pristine and B-, N-, P-, Al-, and Si-doped penta-graphene (PG) toward the NH3, H2S, and SO2 molecules. The results indicate that the pristine PG is insensitive to those toxic gases due to the weak adsorption strength and long adsorption distance. Nevertheless, the doping of B, N, Al, and Si (B and Al) results in the transition of NH3 (H2S and SO2) adsorption from physisorption to chemisorption, which is primarily ascribed to the large charge transfer and strong orbital hybridizations between gas molecules and doping atoms. In addition, NH3 adsorption leads to the remarkable variation of electrical conductivity for the B-, N-, and Si-doped PG, and the adsorption strength of NH3 on the B-, N-, and Si-doped PG is larger than that of H2S and SO2. Moreover, the chemically adsorbed NH3 molecule on the N-, B-, and Si-doped PG can be effectively desorbed by injecting electrons into the systems. Those results shed light on the potential application of PG-based nanosheets as reusable gas sensors for NH3 detection.
The Role of Graphitic Carbon Nitride in the Formulation of Copper-Free Friction Composites Designed for Automotive Brake Pads
Authors: Matějka Vlastimil , Leonardi Mara , Praus Petr , Straffelini Giovanni , Gialanella Stefano
Published: January 2022

In this study, graphitic carbon nitride (g-C3N4, labelled as gCN) was tested in the formulation of copper-free (Cu-free) friction mixtures, which are potentially interesting for brake pad manufacturing. Three formulations of friction composites were prepared starting from a common Cu-free master batch: (i) without graphite, (ii) with graphite and (iii) with gCN. The mixtures were pressed in the form of pins by hot-press moulding. The friction-wear performance of the prepared pins was investigated using a pin-on-disc (PoD) test at room temperature (RT), high temperature (HT) (400 °C) and, again, at room temperature (H-RT). The values of the friction coefficient (µ) for the composites with gCN (or graphite) were as follows: (i) RT test, µRT = 0.52 (0.47); (ii) HT test, µHT = 0.37 (0.37); (iii) RT after the HT tests, µH-RT = 0.49 (0.39). With respect to wear resistance, the samples with graphite performed better than the samples without this solid lubricant. To the best of our knowledge, this is the first report regarding the evaluation of the role of gCN in friction composites designed for automotive brake lining applications. The results indicate the main role of gCN as a soft abrasive.
Mechanism Elucidation of High-Pressure Generation in Cellular Metal at High-Velocity Impact
Authors: Nishi Masatoshi , Tanaka Shigeru , Mori Akihisa , Vesenjak Matej , Ren Zoran , Hokamoto Kazuyuki
Published: January 2022

Cellular metals exhibit diverse properties, depending on their geometries and base materials. This study investigated the mechanism of high-pressure generation during the high-velocity impact of unidirectional cellular (UniPore) materials. Cubic UniPore copper samples were mounted on a projectile and subjected to impact loading using a powder gun to induce direct impact of samples. The specimens exhibited a unique phenomenon of high-pressure generation near the pores during compression. We elucidate the mechanism of the high-pressure phenomenon and discuss the pore geometries that contribute to the generation of high pressures.
All-Optical Modulation Technology Based on 2D Layered Materials
Authors: Yang Hongyan , Wang Yunzheng , Tiu Zian Cheak , Tan Sin Jin , Yuan Libo , Zhang Han
Published: January 2022

In the advancement of photonics technologies, all-optical systems are highly demanded in ultrafast photonics, signal processing, optical sensing and optical communication systems. All-optical devices are the core elements to realize the next generation of photonics integration system and optical interconnection. Thus, the exploration of new optoelectronics materials that exhibit different optical properties is a highlighted research direction. The emerging two-dimensional (2D) materials such as graphene, black phosphorus (BP), transition metal dichalcogenides (TMDs) and MXene have proved great potential in the evolution of photonics technologies. The optical properties of 2D materials comprising the energy bandgap, third-order nonlinearity, nonlinear absorption and thermo-optics coefficient can be tailored for different optical applications. Over the past decade, the explorations of 2D materials in photonics applications have extended to all-optical modulators, all-optical switches, an all-optical wavelength converter, covering the visible, near-infrared and Terahertz wavelength range. Herein, we review different types of 2D materials, their fabrication processes and optical properties. In addition, we also summarize the recent advances of all-optical modulation based on 2D materials. Finally, we conclude on the perspectives on and challenges of the future development of the 2D material-based all-optical devices.
Fast Terahertz Imaging Model Based on Group Sparsity and Nonlocal Self-Similarity
Authors: Ren Xiaozhen , Bai Yanwen , Niu Yingying , Jiang Yuying
Published: January 2022

In order to solve the problems of long-term image acquisition time and massive data processing in a terahertz time domain spectroscopy imaging system, a novel fast terahertz imaging model, combined with group sparsity and nonlocal self-similarity (GSNS), is proposed in this paper. In GSNS, the structure similarity and sparsity of image patches in both two-dimensional and three-dimensional space are utilized to obtain high-quality terahertz images. It has the advantages of detail clarity and edge preservation. Furthermore, to overcome the high computational costs of matrix inversion in traditional split Bregman iteration, an acceleration scheme based on conjugate gradient method is proposed to solve the terahertz imaging model more efficiently. Experiments results demonstrate that the proposed approach can lead to better terahertz image reconstruction performance at low sampling rates.
Piezoelectric MEMS Acoustic Transducer with Electrically-Tunable Resonant Frequency
Authors: Nastro Alessandro , Ferrari Marco , Rufer Libor , Basrour Skandar , Ferrari Vittorio
Published: January 2022

The paper presents a technique to obtain an electrically-tunable matching between the series and parallel resonant frequencies of a piezoelectric MEMS acoustic transducer to increase the effectiveness of acoustic emission/detection in voltage-mode driving and sensing. The piezoelectric MEMS transducer has been fabricated using the PiezoMUMPs technology, and it operates in a plate flexural mode exploiting a 6 mm × 6 mm doped silicon diaphragm with an aluminum nitride (AlN) piezoelectric layer deposited on top. The piezoelectric layer can be actuated by means of electrodes placed at the edges of the diaphragm above the AlN film. By applying an adjustable bias voltage Vb between two properly-connected electrodes and the doped silicon, the d31 mode in the AlN film has been exploited to electrically induce a planar static compressive or tensile stress in the diaphragm, depending on the sign of Vb, thus shifting its resonant frequency. The working principle has been first validated through an eigenfrequency analysis with an electrically induced prestress by means of 3D finite element modelling in COMSOL Multiphysics®. The first flexural mode of the unstressed diaphragm results at around 5.1 kHz. Then, the piezoelectric MEMS transducer has been experimentally tested in both receiver and transmitter modes. Experimental results have shown that the resonance can be electrically tuned in the range Vb = ±8 V with estimated tuning sensitivities of 8.7 ± 0.5 Hz/V and 7.8 ± 0.9 Hz/V in transmitter and receiver modes, respectively. A matching of the series and parallel resonant frequencies has been experimentally demonstrated in voltage-mode driving and sensing by applying Vb = 0 in transmission and Vb = −1.9 V in receiving, respectively, thereby obtaining the optimal acoustic emission and detection effectiveness at the same operating frequency.
Intelligent Design Optimization System for Additively Manufactured Flow Channels Based on Fluid–Structure Interaction
Authors: Ji Haonan , Zou Bin , Ma Yongsheng , Lange Carlos , Liu Jikai , Li Lei
Published: January 2022

Based on expert system theory and fluid–structure interaction (FSI), this paper suggests an intelligent design optimization system to derive the optimal shape of both the fluid and solid domain of flow channels. A parametric modeling scheme of flow channels is developed by design for additive manufacturing (DfAM). By changing design parameters, a series of flow channel models can be obtained. According to the design characteristics, the system can intelligently allocate suitable computational models to compute the flow field of a specific model. The pressure-based normal stress is abstracted from the results and transmitted to the solid region by the fluid–structure (FS) interface to analyze the strength of the structure. The design space is obtained by investigating the simulation results with the metamodeling method, which is further applied for pursuing design objectives under constraints. Finally, the improved design is derived by gradient-based optimization. This system can improve the accuracy of the FSI simulation and the efficiency of the optimization process. The design optimization of a flow channel in a simplified hydraulic manifold is applied as the case study to validate the feasibility of the proposed system.
Influence of Etching Trench on Keff2 of Film Bulk Acoustic Resonator
Authors: Gao Chao , Zou Yang , Zhou Jie , Liu Yan , Liu Wenjuan , Cai Yao , Sun Chengliang
Published: January 2022

As radio-frequency (RF) communication becomes more ubiquitous globally, film bulk acoustic resonators (FBAR) have attracted great attention for their superior performance. One of the key parameters of an FBAR, the effective electromechanical coupling coefficient (Keff2), has a great influence on the bandwidth of RF filters. In this work, we propose a feasible method to tune the Keff2 of the FBAR by etching the piezoelectric material to form a trench around the active area of the FBAR. The influence of the position of the etching trench on the Keff2 of the FBAR was investigated by 3D finite element modeling and experimental fabricating. Meanwhile, a theoretical electrical model was presented to test and verify the simulated and measured results. The Keff2 of the FBAR tended to be reduced when the distance between the edge of the top electrode and the edge of the trench was increased, but the Q value of the FBAR was not degraded. This work provides a new possibility for tuning the Keff2 of resonators to meet the requirements of different filter bandwidths.