bluuebunny/crossref_metadata_2025 huggingface dataset:
IMPACT OF COAL MINING, THERMAL PLANTS, ANTHROPOGENIC ACTIVITIES ON WILDLIFE CORRIDORS FOR NATIONAL PARKS AND WILDLIFE SANCTUARIES IN THE STATE OF MADHYA PRADESH, INDIA
Authors: Galodha A. , Ngoc N. T. , Raniwala D. , Mundia S.
Published: August 2022

Abstract. To the rampant rise in urban settlements and human population, the national parks, wildlife sanctuaries, and national tiger reserves of middle and southern India have been intruded upon by human settlements regularly. These are adjoined by paths called as ‘wildlife corridors’ especially the tiger and elephant corridors which are used as a means for migration. Bandipur and Pench-Satpuda national parks have one such essential pocket of wildlife corridors the Bandipur corridor interconnects the population of 8000 plus elephants between Mysuru and Wayanad in southern India whereas the Pench-Satpuda corridor sustains 120 plus tigers between Pench-Satpuda Tiger Reserve in middle India. To assess this it’s imperative to assess the pattern of wildlife movements, changes in the animal habitats in terms of habitat cluster zones, land-use changes, the onset of human settlements and anthropogenic activities are to be monitored. For this, land use land cover (LULC) changes for these corridors were analyzed across two decades using geospatial and remote sensing technique. The study finds a organized deprivation of dense forests and open forests respectively, thus indicating large-scale destruction. The study also found the net area changes of dense forests and open forests which were diverted for agriculture activities indicating extensive encroachment of forest land for human settlement. The classification was monitored for water bodies that have reduced, indicating shrinkage during the duration under research. The existence of substantial coal deposits in the wildlife corridor and operational coal mining in the proximity of the wildlife corridor is a matter of grave concern which has been highlighted in the research. We examine to identify long-term sustenance and protection of such corridors for preserving the natural habitat. Thus, with such suitability in wildlife monitoring, we can mark an increasing need for adaptable, tenable, and secure wildlife management as illustrated under the Sustainable Development Goals (SDG 15 mentioned under United Nations).
Southern Ocean polynyas and dense water formation in a high-resolution, coupled Earth System Model
Authors: Jeong Hyein , Turner Adrian K. , Roberts Andrew F. , Veneziani Milena , Price Stephen P. , Asay-Davis Xylar S. , Van Roekel Luke P. , Lin Wuyin , Caldwell Peter M. , Wolfe Jonathan D. , Mametjanov Azamat
Published: August 2022

Abstract. Antarctic Bottom Water is an important component of Earth's climate system. Its formation occurs through ocean-atmosphere-sea ice flux interactions in coastal and open ocean polynyas around Antarctica. In this paper, we investigate Antarctic dense water formation in the high-resolution version of the Energy Exascale Earth System Model (E3SM-HR). The model is able to reproduce the major Antarctic coastal polynyas, though they are smaller in area compared to observations. E3SM-HR also simulates several occurrences of open-ocean polynyas (OOPs) in the Weddell Sea, at a higher rate than what the last 50 years of satellite sea ice observational record suggests, but similarly to other high-resolution Earth System Model simulations. Furthermore, the densest water masses in the model are formed within the OOPs, rather than on the continental shelf, as is typically observed. Biases related to the lack of dense water formation on the continental shelf are associated with overly strong atmospheric polar easterlies, which lead to a strong Antarctic Slope Front and hence too little communication between on and off continental shelf water masses. Strong polar easterlies also produce excessive southward Ekman transport, causing a build-up of sea ice over the continental shelf and enhanced ice melting in the summer season. This in turn produces water masses on the continental shelf that are overly fresh and less dense relative to observations. Our results indicate that the large-scale polar atmospheric circulation around Antarctica must be accurately simulated in models to properly reproduce Antarctic dense water formation.
Reactive Hyperplasias in the Oral Mucosa: Case Series
Authors: BAĞCI Nuray , PEKER İlkay , ÜÇOK Özlem
Published: August 2022

Aim: Reactive hyperplasias are often encountered tumor-like exophytic lesions of the oral mucosa, but they are not a neoplasm. Local factors such as dental calculus, food residue stuck between teeth, incompatible prosthetic restoration, and systemic factors such as hormonal changes play a role in the etiology of these hyperplasia. The aim of this presentation is to evaluate the possible etiological factors, clinical, and radiological findings of 10 reactive hyperplasia cases seen in different regions of the mouth.

Case report: Ten patients (seven females and three males) with a mean age 40.2 applied to our clinic with complaints of swelling in the mouth. In the medical anamnesis, it was learned that three (30%) patients had recently given birth and the related swelling started to occur in the second trimester of pregnancy, three (30%) patients had different diseases such as heart, hypertension, diabetes, and cholesterol, and were under regular medication for systemic disease. There is no finding on extraoral examination. In intraoral examination, mass lesions which red and/or pink, lobular/nodular, painless, pedunculated and/or sessile, and smooth and/or ulcerated was seen on the maxilla of six patients, mandible of three patients, and lower lip mucosa of one patient. Poor oral hygiene in seven (70%) patients, prosthetic restoration in the lesion-related area in two (20%) patients, and attrition incisal tooth surface and diastema in one (10%) patient were found. Radiographic examination revealed that minimal resorption on the alveolar crest in the lesion-related area of only three (30%) patients was seen. All lesions were histopathologically examined after surgical excision. According to the clinic, radiographic and histopathological features, diagnosis of the lesions was made as pyogenic granuloma (four cases; 40%), peripheral ossifying fibroma (three cases; 30%), traumatic fibroma (two cases; 20%) and peripheral giant cell granuloma (one case; 10%).

Conclusion: It was concluded that the lesions examined in this case series were mostly caused by local factors. The clinical findings observed in the patients were red nodular mass, painless, soft, and smooth-surfaced. In the radiographic examination, no finding was detected in most of the lesions.
ENDOCROWN RESTORATION OF THE ENDODONTICALLY TREATED TEETH BY USING CAD/CAM: CASE SERIES
Authors: ÜNLÜ KURŞUN Begüm , AKAN Ender
Published: August 2022

Aim: As a result of large coronal destruction in endodontically treated teeth, significant losses occur in the dentin tissue around the pulp and the need for prosthetic treatment occurs. In this case series, endocrown applications produced in a single session with CAD/CAM system are presented as an alternative to crown restoration traditionally applied to premolar and molar teeth with excessive crown destruction. Case Series: In first case, 38-years-old male patient number 25, 46-years-old female patient number 36 in our second case, 21-years-old female patient number 46 in our third case, 26-years-old male patient number 46 in our fourth case, and in the last case 52-years-old male patient tooth number 15 has been applied to root canal treatment. As a result of the clinical and radiological examinations of the patients, it was observed that there were no systemic diseases. Endocrown restoration was considered appropriate and recommended to patients with less dentin tissue. Firstly, teeth are prepared for endocrown restoration. Afterwards, the impressions were digitalized by scanning the jaws with an intraoral optical scanner (Cerec Omnicam, Dentsply Sirona, USA). The restorations were designed with the help of the CEREC 4.3 software (Dentsply Sirona, USA) and the milling process was carried out using the feldspathic ceramic block (Vita Mark II, Vita Zahnfabrik, Germany) in the same session by CEREC inLab MC XL (Dentsply Sirona, USA). Later, the restorations were glazed and cemented with dual polymerized resin cement (RelyX Ultimate, 3M ESPE, USA). Conclusion: Endocrown restorations are a minimally invasive, conservative treatment approach that provides mechanical adhesion to the pulp chamber and cavity walls with adhesive resin cement and allows the preservation of the remaining tooth structure. For this reason, it is a treatment option that can be preferred instead of post-core and crown application in teeth with root canal treatment.
ASSESSMENT OF JUXTA-APICAL RADIOLUCENCY WITH CONE BEAM CT
Authors: COŞKUN Sinem
Published: August 2022

Aim: This study aimed to investigate the association of JAR with third molar status and mandibular canal and also describe its radiologic features through cone beam computed tomography (CBCT).

Methods: CBCT images of 100 individuals (153 mandibular third molars) were evaluated for the presence of JAR. Than, the CBCT images were analysed to evaluate the position of the JAR and its relationship to the impacted teeth, mandibular canal and buccal-lingual cortical plates. Descriptive statistical analyses were used.

Results: JAR was identified in 70 individuals and 95 mandibular third molars (48 right side, 47 left side). 22 of the individuals with JAR were male and 48 were female. It was found that 26 (27,4%) of the 95 third molars were erupted, 10 (10,5%) were partially erupted, 59 (62,1%) were impacted. 74,7 % were on the apical third of the root and the rest was located along the mesial or distal surfaces of root. Close proximity to the buccal cortical plate was seen in 25,35 % of JAR located apically, whereas it was seen only 25% of JAR located along the root surface. Only 23.4 % were associated with the mandibular canal.

Conclusion: The present study gives an insight into the relationship of JAR with mandibular canal and cortical plates using CBCT. However, future studies are warranted that use a larger sample size to validate the above findings.
IN VITRO COMPARISON OF INDIRECT BONDING METHODS USING DIFFERENT ISOLATION AND ADHESIVE SYSTEMS WITH EACH OTHER AND WITH THE DIRECT BONDING TECHNIQUE
Authors: KILIÇ Banu , DORUK Ercan Cenk
Published: August 2022

Aim: To compare the shear bond strength and adhesive remnant index of a new indirect bonding isolation method for different adhesive systems with the direct bonding technique.

Methods: 100 premolar and 10 centrally extracted human teeth were bonded with one direct and four indirect bonding methods, and then subjected to 1000 thermal cycles between 5°C and 55°C. ARI was analyzed by the chi-square test. The Shear Bond strength was analyzed by the analysis of variance (ANOVA) and the Tukey multiple comparison (HSD) test. The bracket-enamel interface area of two teeth from each group was examined under SEM.

Results: All groups provided clinically acceptable bond strengths. In the traditional isolation + light-cured bonding group with the highest bonding values identified, the scores for all failures were recorded as 3 and this group differs from all other groups in respect of ARI scores (p
PRESENÇA DO ACOMPANHANTE NA PERSPECTIVA DA MULHER DURANTE O PARTO
Authors: Mazzetto Fernanda Moerbeck Cardoso , Mattos Taynara Bernardo de , Siqueira Fernanda Paula Cerântola , Ferreira Maria de Lourdes Da Silva Marques
Published: August 2022

Objetivo:  Compreender o que significou, na percepção da puérpera, ter a presença do acompanhante no momento do trabalho de parto, parto e pós-parto. Método: Trata-se de um estudo de campo qualitativo, com a utilização da fenomenologia. Foram entrevistadas oito puérperas. Resultados: emergiram os temas: 1 Segurança, apoio e divisão do momento com alguém; 2 Confiança, com apoio físico e emocional; 3 Fortalecimento da relação familiar; 4 Acolhida positiva e negativa do acompanhante pela equipe de saúde; 5 Busca de informações sobre o direito do acompanhante; 6 Despreparo para o parto. Considerações Finais: A presença do acompanhante garante apoio físico, emocional e fortalecimento da relação familiar. Os acompanhantes são acolhidos pela equipe de saúde, mas, em contrapartida, ainda não valorizam a importância de sua presença. É preciso refletir sobre o desafio de garantir a presença de acompanhante e o respeito aos direitos de humanização do parto.
PROPAGANDAS E CAMPANHAS DE ALEITAMENTO MATERNO: PERCEPÇÃO DE MULHERES MEMBROS DE GRUPOS VIRTUAIS
Authors: Hartmann Melissa , Rodrigues Matheus Dos Santos , Ribeiro Juliane Portella
Published: August 2022

Objetivo: conhecer a percepção de mulheres, que participam de grupos virtuais hospedados no Facebook, acerca do conteúdo veiculado por propagandas e campanhas, de 1921 até a atualidade, que envolvem a temática de aleitamento. Método: pesquisa de caráter exploratório e descritivo. Participaram 15 mulheres membros de dois grupos virtuais hospedados no Facebook. A coleta de dados sucedeu-se na plataforma, por meio de um formulário associado ao método de foto-elicitação. Posteriormente, empregou-se a análise de conteúdo. Resultados: As participantes identificaram que as propagandas do ramo alimentício, ao longo dos anos, contribuíram na construção da falsa crença de que o leite artificial é superior ao leite materno; o que necessitou posteriormente de campanhas de incentivo à amamentação. Considerações finais: As campanhas recentes apontam a importância tanto da rede de apoio quanto da garantia aos direitos da nutriz para que o aleitamento materno se estabeleça conforme o recomendado pela Organização Mundial da Saúde. Contudo, as campanhas construíram um romantismo em torno do aleitamento e da figura materna; fato que, culminou na sua responsabilização pelo sucesso da amamentação.
Impact of Proactive Personality on Affective Commitment: Mediation Effect of Job Satisfaction
Authors: Awan Tajammal Hussain , Abid Muhammad Adeel , Aslam Muhammad Shahzad , Hafeez Muhammad Mohsin , Akram Muhammad Shahzad
Published: August 2022

Organizations are finding it harder and harder to improve their performance amid fierce competition. Globalization is causing markets to transition from traditional to digital, and as new things are developed, product lifecycles are getting shorter. Organizations don't always grow in the same way. The political, social, and environmental factors make doing business in developing nations very challenging. Business studies courses emphasize the role of staff in overcoming issues like this. Proactive workers look for a company that can adapt to their work and environmental situations. According to this study, individuals' proactive personalities under the effect of perceived organizational support result in affective commitment by job satisfaction. Through a Google form, 221 respondents in managerial positions were randomly selected from manufacturing and service firms. SPSS V.20 was employed for the data analysis. Using the Hayes method, mediation and moderated mediation analysis. The findings indicate a connection between proactive personality and emotional commitment through job satisfaction, and that this connection will become stronger as perceived organizational support increases. Proactive personality with affective commitment are partially mediated. Empirically, all three of the study's hypotheses were confirmed. Managers and practitioners will benefit from this study's decision-making advice.
Biologically active substances in the aboveground part of three Stellaria speciesx
Authors: Garnova Natalya , Filippova Alla , Kasatkin Mikhail , Tikhonova Yuliya
Published: August 2022

The phytochemical screening of potentially efficient medicinal herbs is one of the current focus areas of modern pharmacochemistry. This work aims to analyze the phytochemical composition of the aboveground parts in three Stellaria species (S. bungeana, S. graminea, S. holostea). The study was conducted between May and July 2020 in the Moscow region of the Russian Federation. Yield values for raw herbal materials and density of stitchwort samples per 1 m2 (154 sites in total) were recorded, followed by a phytochemical analysis of the dry mass by chromatography. The maximum yield of S. bungeana was established to be 1.5 times higher than in two other species (p ≤ 0.05). In S. graminea, the maximum pectin concentration was 12 times higher than in S. holostea (p ≤ 0.001) and 0.5 times higher than in S. bungeana (p ≤ 0.05). The number of polysaccharides in S. bungeana was 14 times higher than in S. graminea (p ≤ 0.001) and two higher than in S. holostea (p ≤ 0.05). Hemicellulose content of S. bungeana extract was twice as high as that of other species (p ≤ 0.05). Tannins in S. graminea were found two times more often than in S. holostea (p ≤ 0.05) and eight times more often in S. bungeana (p ≤ 0.01). Vitamin C content in S. graminea was two times greater than in the other two stitchwort species (p ≤ 0.05). Stitchwort is a common, widespread plant that makes it easy to collect without harming plant communities. Biologically active substances (polysaccharides, vitamin C, tannins, and pectins) were found in the composition of all stitchwort species with a preventive and therapeutic effect on the human body. The concentration of tannins and vitamin C is maximal in S. graminea extract, amounting to 2.6% and 45.9%, accordingly. The extract from S. bungeana contains a lot of hemicellulose (13.2%) and polysaccharides (7.2%). No high concentration of these substances was recorded in S. holostea, which makes this species the least pharmaceutically valuable. S. graminea and S. bungeana plants can be recommended for pharmaceutical processing due to the high concentrations of vitamin C, pectins, tannins, polysaccharides, and hemicellulose.
Development of a Stability-indicating RP-UPLC Method for determination of Fidarestat in Bulk Drug
Authors: Sakariya Twinkle , Bhaloddiya Monika , Shah Anamik
Published: August 2022

An accurate, precise, robust and selective stability-indicating liquid chromatographic (UPLC) method has been developed for the monitoring of Fidarestat in the presence of its forced degradants. The drug was subjected to hydrolysis (acid and alkali), oxidation, photolysis and thermal stress conditions. The drug degraded significantly under hydrolytic and oxidative stress conditions, whereas it was found to be stable in photolytic and thermal conditions. The mobile phase consisted of 0.1% formic acid and methanol in the ratio of (50:50, v/v). The flow rate was 0.5ml/min, column temperature 30°C, the injec¬tion volume was 20µL, and sample was monitored at 283nm using a PDA detector over a concentration range of 20 - 180μg/ml with correlation coefficient of 0.997. The developed LC method was validated as per ICH guideline Q2 (R1). The proposed method was found to be successively applied for the quality control of Fidarestat in bulk drug analysis.
Histological effect of Plantago lanceolata on different Mice Organs
Authors: Al-Obaidi Zina F.H. , Ahmed Okhti Zahraa
Published: August 2022

Medicinal plants, have been revealed and used in conventional therapy applies as primeval periods. Plants synthesized many chemicals to be act against insects, fungal infection, different diseases and bacteria. Where the singular plant comprises broadly diverse phytochemicals, but some time these effects may be uncertain. Plantago lanceolata one of the important medicinal plant due to numerous phytochemicals with potential pharmacological actions such as mucilage, glycosides, tannins, minerals such as silica, zinc, potassium etc. This study aimed to evaluate the capacity of P. lanceolate to modulate and counteract any damaged induced by methotrexate drug on testis and spleen of albino male mice for that four mice groups were used in study: group I, mice treated with 400 mg\kg of aqueous plant extract, group II, mice administrated with methotrexate drug at a dose of 40mg\kg group III an interaction group between drug and plant. The results indicated the P.laceolata to repair any abnormality and reduce the toxicity of drug and all these activity due to tannin, alkaloid, flavonoid and caffeic acid contents.
Gastric plexiform fibromyxoma in children: A new case report and review of pediatric literature
Authors:   Department of Pediatric Surgery, ", Moglia Cristina ,   Spedali Civili",   Children's Hospital, Brescia, Italy., Parolini Filippo ,   Department of Pediatric Surgery, "Spedali Civili" Children's Hospital, Brescia, Italy., Villanacci Vincenzo ,   Pathology Unit, ASST Spedali Civili, Brescia, Italy., Gaetano Giuseppe di ,   Pediatric Radiology Unit, ASST Spedali Civili Brescia, Brescia, Italy., Moneghini Dario ,   Endoscopy, ASST Spedali Civili di Brescia, Brescia, Italy, ASST Spedali Civili Brescia, Brescia, Italy., Domenico Della Casa ,   Pediatric Radiology Unit, ASST Spedali Civili Brescia, Brescia, Italy., Pignata Giusto ,   Department of General Surgery II, Spedali Civili, Brescia, Italy., Boroni Giovanni ,   Department of Pediatric Surgery, "Spedali Civili" Children's Hospital, Brescia, Italy., Alberti Daniele ,   Department of Pediatric Surgery, "Spedali Civili" Children's Hospital, Brescia, Italy.
Published: August 2022

Introduction: Plexiform Fibromyxoma (PF), also known as Plexiform Angiomyxoid Myofibroblastic Tumour (PAMT) is a rare mesenchymal myxoid tumour originating in different areas of the digestive system. Symptoms and signs are usually elusive: the most common are abdominal discomfort, dyspepsia, nausea and gastrointestinal bleeding with anemia and hematemesis. Imaging tests are useful to identify plexiform fibromyxoma, but only pathology provides the definitive diagnosis and differentiate it from other mesenchymal tumours. PF seems to display a benign behaviour and the only complete surgical removal of the mass represents the gold standard of treatment; no recurrence or metastasis has been described so far. A little more than 100 cases have been described in adulthood with only 14 cases reported up to now in pediatrics. Case report and review: We report the case of a gastric plexiform fibromyxoma occurred in an 8-year old girl went to our observation with a story of dyspepsia, vomiting, weight loss and anemia. A 4 X 2.5 cm mass was found in the gastric antrum. The tumour was removed by laparoscopic antrectomy and the pathological exam was consistent with PF. A detailed review of PF pediatric literature is also provided. Keywords: plexiform fibromyxoma; gastric tumour; pediatrics; laparoscopic gastric resection.
May-Thurner syndrome successfully managed with an endovascular stent: A case report
Authors:   Department of General Surgery, Hospital Sultanah Aminah, Johor Bahru, Johor, Malaysia., Junloong Chiew , AM Maizatul Aliaa ,   Department of General Surgery, Hospital Sultanah Aminah, Johor Bahru, Johor, Malaysia., Z Ismazizi ,   Department of General Surgery, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia., AA Zainal ,   Department of General Surgery, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia.
Published: August 2022

May-Thurner Syndrome (MTS) or iliac vein compression syndrome is caused by compression of the left common iliac vein by the right common iliac artery. The incidence rate of MTS is unknown. In an autopsy study in the early twentieth century, the incidence ranges from 22 to 32%. MTS-related deep venous thrombosis accounts for only 2%-3% of all lower limb DVTs. The patient may present with leg swelling, varicosities, deep venous thrombosis, chronic venous stasis ulcers, or more serious complications, such as pulmonary embolism. Iliac vein compression can be assessed with Computed Tomography (CT) and iliac venography. The goal of treatment is to reduce symptoms and the risk of complications. Stent placement is an alternative method to a direct surgical approach. We present 2 cases of MTS that were treated with stent placement.
Health coaching experience in Minerbio (Italy): Global impact on weight, BMI, waist circumference and blood pressure
Authors:   FISS, Fondazione Istituto di Scienze della Salute, Bologna, Italy., Andrea Plazzi , Maria Di Fine ,   FISS, Fondazione Istituto di Scienze della Salute, Bologna, Italy., Roda Giulia ,   FISS, Fondazione Istituto di Scienze della Salute, Bologna, Italy., Roda Enrico ,   FISS, Fondazione Istituto di Scienze della Salute, Bologna, Italy.
Published: August 2022

In the last decade, growing evidence have shown the cardioprotective role of the Mediterranean diet. Health coaching has a pivotal role in primary care, helping patients to self-education concerning diet and physical activity. Our study is a one-year health coaching pilot study with the aim to instruct patients' lifestyle to a Mediterranean diet and exercises to reduce cardiovascular disease risks, diabetes, and metabolic diseases risks.
An unusual case of massive GI bleeding in an immunosuppressed patient
Authors:   San Fernando School of Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru., Lagos J Samuel , Mehta Amit ,   New York-Presbyterian Weill Cornell Medical Center, New York, NY, USA., Wan David ,   New York-Presbyterian Weill Cornell Medical Center, New York, NY, USA.
Published: August 2022

Nematode hyperinfection classically presents with eosinophilia; however, immunosuppressed patients on corticosteroid therapy or with chronic HTLV 1-2 infection do not necessarily express this eosinophilic pattern. We present a patient with T cell lymphoma and HTLV 1-2 infection with massive GI bleeding that illustrates this atypical scenario. Concomitant pyogenic infection and/or steroid administration can blunt the eosinophilia response in Strongyloides infections, and it is important to rule out the infection in a patient from an endemic area. Keywords: strongyloides infection; HTLV; GI bleeding.
Toux aiguë : pour la première fois, une recommandation claire pour l'ambroxol comme traitement symptomatique
Authors: Mueck Tobias
Published: August 2022

Selon les directives de la Société allemande de pneumologie, une toux aiguë associée à un rhume sans signes cliniques d'une pneumonie ou d'autres signaux d'alarme relève du domaine de l'automédication. La durée (jusqu'à deux semaines) est le critère crucial pour qu'elle soit considérée comme "aiguë". Partant de leur évaluation d'études contrôlées et randomisées, les auteurs ont conclu que l'ambroxol (de même que quelques médicaments phytothérapeutiques) réduit la durée et/ou l'intensité de la toux en cas de bronchite aiguë. Le dextrométhorphane est recommandé par les auteurs de la directive pour une toux sèche, gênante associée à une infection des voies respiratoires supérieures.
Ambroxol snižuje frekvenci kašle (během dne i v noci), a tím zlepšuje schopnost soustředění a kvalitu života
Authors: Mueck Tobias
Published: August 2022

Ve studii prováděné v lékárnách byly zjišťovány odpovědi zákazníků, kteří užívali jednu ze čtyř různých lékových forem ambroxolu na akutní kašel. Výsledky ukázaly terapeutické přínosy ambroxolu při samoléčbě akutního kašle. Různé lékové formy vykazovaly srovnatelnou účinnost.
Alivio de la tos aguda con un jarabe para la tos con acción mucoprotectora
Authors: Mueck Tobias
Published: August 2022

En dos estudios multicéntricos, aleatorizados, con enmascaramiento y controlados se investigó el efecto terapéutico de una barrera químico-mecánica de un jarabe para la tos elaborado a base de polisacáridos, resinas y miel en las vías respiratorias altas en niños con tos aguda asociada a un resfriado común. Este efecto mucoprotector condujo a un alivio significativo de la tos en pacientes pediátricos en comparación con el jarabe de carbocisteína o el placebo. El beneficio de este efecto fue especialmente evidente en niños que padecían tos severa y/o episodios de tos nocturna.
Soulagement de la toux aiguë par un sirop contre la toux offrant une muco-protection
Authors: Mueck Tobias
Published: August 2022

Deux études multicentriques randomisées, contrôlées, en aveugle ont étudié l'effet thérapeutique au niveau des voies respiratoires supérieures d'une barrière chimique et mécanique produite par un sirop contre la toux à base de polysaccharide-résine-miel chez des enfants atteints de toux aiguë en présence d'un rhume ordinaire. La muco-protection a mené à un soulagement significatif de la toux pédiatrique par rapport à un sirop à la carbocystéine ou un placebo. L'effet bénéfique était particulièrement prononcé chez les enfants ayant une toux sévère et/ou des épisodes de toux nocturne.
Karaktäristiska förhållanden för kvinnor i samband med förekomst och behandling av förstoppning
Authors: Landes Sabine
Published: August 2022

Förstoppning påverkar inte bara daglig tarmtömning, utan även det allmänna välmåendet. En onlineundersökning med fler än 5 000 deltagare visade att kvinnor ofta påverkas i större utsträckning – både fysiskt och känslomässigt – än män. Vad gäller behandling visade data från studier av laxermedlen bisakodyl och natriumpikosulfat att kvinnor svarar snabbare på laxermedel och att de avseende livskvalitet får större nytta av behandling än män.
Propriétés pharmacocinétiques de l'ibuprofène : comparaison entre l'association à dose fixe d'ibuprofène plus caféine, le lysinate d'ibuprofène et l'acide d'ibuprofène
Authors: Weiser Thomas
Published: August 2022

Les antalgiques contenant de l'ibuprofène facilement soluble (p. ex. en tant que lysinate) ont été développés dans le but d'assurer un soulagement plus rapide de la douleur qu'avec l'ibuprofène sous forme d'acide, grâce à une absorption plus rapide dans le tractus gastro-intestinal. Étant donné que le degré de remplissage gastrique peut avoir une influence significative sur l'absorption, deux études ont évalué la pharmacocinétique du lysinate d'ibuprofène et de l'ibuprofène sous forme d'acide (en association avec la caféine) sur un estomac vide (à jeun) et après un petit-déjeuner standard. L'absorption de l'ibuprofène sous forme de lysinate n'a été plus rapide qu'en cas de prise à jeun ; après un petit-déjeuner standard, le temps nécessaire pour atteindre le pic de concentration plasmatique s'est avéré plus court avec l'ibuprofène sous forme d'acide (avec la caféine) qu'avec le lysinate d'ibuprofène. Étant donné que les antalgiques ne sont généralement pas pris sur un estomac vide, cela réduit les avantages attribués au lysinate d'ibuprofène.
Az ibuprofén farmakokinetikája: az ibuprofén és koffein fix kombinációjának összehasonlítása ibuprofén-lizináttal és ibuprofénsavval. Két – egyszeri adaggal végzett – vizsgálat eredményei (randomizált, egyközpontú, keresztezett, nyílt jelölésű)
Authors: Weiser Thomas
Published: August 2022

A könnyen oldódó ibuprofént (például lizinátként) tartalmazó fájdalomcsillapítókat azzal a céllal fejlesztették ki, hogy a gyomor-bél traktusban történő gyorsabb felszívódás révén gyorsabb fájdalomcsillapítást biztosítsanak, mint az ibuprofénsav. Mivel a gyomor telítettségének mértéke jelentősen befolyásolhatja az abszorpciót, ezért két tanulmány vizsgálta az ibuprofén-lizinát és az ibuprofén-sav (koffeinnel kombinálva) farmakokinetikáját éhgyomorra és szokásos reggeli után. Az ibuprofén lizinátként történő felszívódása csak akkor volt gyorsabb, ha éhgyomorra vették be. A szokásos reggeli után az ibuprofén-savval (koffeinnel) való plazmaszint elérésének ideje rövidebb volt, mint az ibuprofén-lizinát esetében. Mivel a fájdalomcsillapítókat általában nem éhgyomorra veszik be, ez csökkenti az ibuprofén-lizinát állítólagos előnyeit.
Наскоро проведен метаанализ на ефикасността на ментово масло при синдром на раздразненото черво
Authors: Weigmann Harald
Published: August 2022

Мета-анализът показа, че ментовото масло е ефективно и безопасно лекарствено средство за лечение на симптомите на синдром на раздразнените черва. В седем клинични проучвания ментовото масло очевидно превъзхожда плацебо по отношение на подобрението на общите симптоми на синдрома на раздразненото черво. По отношение на страничните ефекти не е установена статистически значима разлика между ментовото масло и плацебо.
Кофеинът - енергизиращ и ароматен: но и безопасен!
Authors: Weiser Thomas
Published: August 2022

Европейският орган за безопасност на храните е извършил цялостна оценка на риска и е стигнал до заключението, че редовната консумация през целия живот на кофеин до 400 mg дневно от 18-годишна възраст от здрави възрастни и до 200 mg при бременни и кърмещи жени може да се счита безопасна. Преглед на резултатите от различни страни показа, че консумацията на кофеин е в безопасни граници при 95% от анкетираните.
La caféine : stimulante, aromatique… et sûre !
Authors: Weiser Thomas
Published: August 2022

L'Autorité européenne de sécurité des aliments a mené une évaluation exhaustive des risques et a conclu qu'une consommation régulière dès l'âge de 18 ans et tout au long de la vie d'une quantité allant jusqu'à 400 mg de caféine par jour chez les adultes en bonne santé et jusqu'à 200 mg par jour chez les femmes enceintes et allaitantes, peut être considérée comme sans danger. Un aperçu de différents pays a montré que la consommation de caféine se trouvait dans une fourchette saine dans 95% des cas.
La caffeina: non solo energizzante e aromatica, ma anche sicura!
Authors: Weiser Thomas
Published: August 2022

L'Autorità europea per la sicurezza alimentare ha svolto una valutazione completa dei rischi e ha concluso che l'assunzione regolare per tutto l'arco della vita di un massimo di 400 mg di caffeina al giorno a partire dai 18 anni nel caso degli adulti sani e di un massimo di 200 mg al giorno nel caso delle donne in gravidanza o che allattano al seno può essere considerata sicura. Dall'analisi di un campione rappresentativo comprendente persone di diversi paesi è emerso che il consumo di caffeina del 95% dei soggetti intervistati ricade nell'intervallo considerato sicuro.
Okoznak-e álmatlan éjszakákat a koffeintartalmú kombinált fájdalomcsillapító készítmények?
Authors: Weiser Thomas
Published: August 2022

Két vizsgálatban nem találtak releváns hatást a betegek alvásminőségére, amelyek során az ibuprofént 100 mg koffeinnel kombinálva, naponta háromszor vették be. Összesen 538 beteg közül, 100 alanyból csak egy-kettőnél fordult elő a gyógyszeres kezelés okozta alvászavar. Az egyik vizsgálatban a résztvevők mindössze 0,8%-a számolt be alvászavarról – pontosan ugyanannyi százalékban, mint a placebo csoportban.
Gli analgesici di combinazione contenenti caffeina possono causare notti insonni?
Authors: Weiser Thomas
Published: August 2022

Due studi nei quali l'ibuprofene è stato assunto in combinazione con 100 mg di caffeina tre volte al giorno non hanno mostrato effetti significativi sulla qualità del sonno dei soggetti coinvolti. Su un totale di 538 pazienti, solo 1-2 partecipanti su 100 hanno riscontrato problemi del sonno causati dal trattamento. In uno dei due studi, ha sperimentato disturbi del sonno solo lo 0,8% dei partecipanti, esattamente la stessa percentuale rilevata nel gruppo che aveva ricevuto il placebo.
Antalgiques contenant des adjuvants ; association avec la caféine
Authors: Weiser Thomas
Published: August 2022

Une étude bibliographique par le groupe Cochrane Collaboration a comparé les effets antalgiques d'un antalgique courant avec ceux de l'association de cet antalgique et de la caféine. L'ajout de caféine a augmenté significativement la proportion de patients qui ont ressenti un soulagement efficace de la douleur dans toutes les affections douloureuses étudiées. Les auteurs n'ont pas trouvé de signalements d'événements indésirables graves en lien avec l'antalgique ou la caféine.
Dalla disattivazione virale in vitro alla rilevanza clinica: uno spray orale contenente glicerolo e tripsina di merluzzo contro il raffreddore comune
Authors: Schuett Tanja , Loehn Matthias
Published: August 2022

La tripsina di merluzzo in combinazione con il glicerolo si è dimostrata in grado di disattivare i virus del raffreddore comune in vitro. Uno studio pilota e uno studio multicentrico comparativo hanno esaminato la riduzione della carica virale in vivo e il miglioramento della qualità della vita a seguito dell'uso di questi principi attivi sotto forma di uno spray per la gola da parte di soggetti con raffreddore comune. I risultati hanno evidenziato una riduzione della carica virale e della durata del raffreddore, come pure un miglioramento della qualità della vita.
Efficacité et tolérance de l'ambroxol chez l'enfant
Authors: Mueck Tobias
Published: August 2022

Une étude bibliographique a récapitulé un grand nombre de données cliniques publiées et non encore publiées à ce jour sur l'utilisation de l'ambroxol chez les enfants et a évalué les résultats. Il a été démontré que l'ambroxol est un traitement sécrétolytique efficace chez les enfants atteints de maladies respiratoires aiguës et chroniques. L'ambroxol, dont la surveillance continue a démontré l'innocuité depuis de nombreuses années a présenté un rapport bénéfice-risque favorable chez les adultes et les enfants de tous âges.
Az ambroxol hatékonysága és tolerálhatósága gyermekeknél
Authors: Mueck Tobias
Published: August 2022

Egy összefoglaló közlemény átfogó klinikai, közzétett és még nem publikált adatokat foglalt össze és értékelt az ambroxol használatával kapcsolatban, gyermekeknél. Az ambroxol hatékony szekretolitikus terápiának bizonyult akut és krónikus légzőszervi megbetegedésekben szenvedő gyermekeknél. Az ambroxol biztonságosságának több éves folyamatos ellenőrzése során a gyógyszer kedvező előny-kockázat profilt mutatott felnőtteknél és bármilyen életkorú gyermekeknél.
Makrogol – irányelveken alapuló kezelés székrekedésre
Authors: Eberlin Marion , Schuett Tanja
Published: August 2022

A széklet gyakoriságának növelése és állagának javítása döntő szerepet játszanak a székrekedés enyhítésében. Nemzetközi és nemzeti iránymutatások is elismerik a makrogol bizonyított, pozitív hatását mindkét paraméterre. Jól tolerálhatónak és biztonságosnak tekintik. Néhány irányelv azonos mértékben javasolja a stimuláns hashajtókat, a biszakodilt és a nátrium-pikoszulfátot.
Laxativa u dětí? Nová studie potvrdila účinnost a snášenlivost dlouhodobého užívání bisakodylu
Authors: Eberlin Marion
Published: August 2022

Retrospektivní studie zjišťovala účinnost snášenlivost dlouhodobého a pravidelného používání bisakodylu u dětí. Bisakodyl byl u dětí účinný, bezpečný a dobře tolerovaný i při dlouhodobém užívání (průměrná délka léčby: 14 měsíců). Obavy ohledně vzniku závislosti se prokázaly nepodložené; u většiny pacientů lze bisakodyl postupně vysadit, aniž by se změnila frekvence stolice.
¿Laxantes en niños? Un nuevo estudio confirma la eficacia y la tolerabilidad del uso de bisacodilo a largo plazo
Authors: Eberlin Marion
Published: August 2022

Un estudio retrospectivo evaluó la eficacia y la tolerabilidad del uso a largo plazo y regular de bisacodilo en niños. Incluso cuando se tomaba durante un largo período (duración media del tratamiento: 14 meses), el bisacodilo resultó ser eficaz, seguro y bien tolerado en los niños. La preocupación por el desarrollo de la dependencia resultó ser injustificada; en la mayoría de los pacientes, el bisacodilo pudo dejarse de forma gradual sin ningún cambio en la frecuencia de las deposiciones.
Hashajtók alkalmazása gyermekeknél: egy új vizsgálat igazolja a biszakodil hatásosságát és tolerálhatóságát hosszan tartó alkalmazás esetén
Authors: Eberlin Marion
Published: August 2022

Egy retrospektív tanulmány a hosszútávú és rendszeres biszakodil alkalmazás hatékonyságát és tolerálhatóságát vizsgálta gyermekeknél. Hosszútávú szedés esetén is (a kezelés átlagos időtartama: 14 hónap) a biszakodil gyermekeknél hatékony, biztonságos és jól tolerált. A függőség kialakulásával kapcsolatos aggodalmak indokolatlannak bizonyultak. A páciensek többségénél a biszakodil fokozatos elhagyása nem járt a széklet gyakoriságának változásával.
Il dexibuprofene: identikit
Authors: Gazova Andrea , Kyselovic Jan , Koscova Eva
Published: August 2022

Il dexibuprofene, l’enantiomero farmacologicamente attivo dell’ibuprofene, mostra una buona efficacia contro il dolore sia acuto sia cronico. Il presente articolo offre un compendio dei risultati degli studi che confermano come il dexibuprofene sia un’alternativa efficace e sicura se confrontato con l’ibuprofene e altri COX-inibitori.
Rinite allergica e inquinamento atmosferico: nuove evidenze cliniche con la fexofenadina cloridrato 180 mg
Authors: Murrieta-Aguttes Margarita , Volonte Marina
Published: August 2022

L’esposizione agli inquinanti atmosferici e il cambiamento climatico sono entrambi fattori che contribuiscono all’aumento della prevalenza e all’esacerbazione dei sintomi della rinite allergica (RA). La fexofenadina cloridrato 180 mg si è dimostrata efficace nell’offrire sollievo dai sintomi della RA da polline aggravata dall’inquinamento atmosferico in uno studio clinico controllato randomizzato (lo studio FEXPOLSAR) che ha utilizzato un modello di sfida allergenica controllata riconosciuto e convalidato per la RA.
Il bisacodile: risultati completi indicano come usarlo in maniera sicura ed efficace contro la stipsi
Authors: Landes Sabine , Eberlin Marion , Lange Robert
Published: August 2022

Per la prima volta da quando l’uso del bisacodile è stato autorizzato, negli anni ‘50, una revisione aggiornata delle evidenze disponibili fornisce una sintesi completa e accurata dei dati clinici e farmacologici relativi a questo lassativo procinetico e secretagogo. Sulla base delle conoscenze acquisite nel corso dei numerosi anni di esperienza con il farmaco, tale revisione produce indicazioni pratiche su come consigliare i pazienti al fine di rendere l’uso del bisacodile ancor più sicuro ed efficace.
Deneysel Tasarım Psödoefedrin ve Setirizinin Dökme ve Tabletlerde Optimize Kromatografik Tayini
Authors: REİD Imad
Published: August 2022

Kombine setirizin ve psödoefedrin tablet dozaj formundan ayrılması, bir siyanopropil kolonu ve 1 mL / dakikada pompalanan amonyum asetat tamponu (20 mM, pH 5.5) ve asetonitrilden (44: 56v / v) oluşan bir mobil faz kullanılarak elde edildi. analitler 240 nm'de izlendi. Yöntem, psödoefedrin ve setirizin için sırasıyla 25-135 μg / mL ve 1.5-7.5 μg / mL arasında doğrusalydı. Psödoefedrin ve setirizin için saptama sınırları sırasıyla 5.34 ve 0.13 μg / mL iken, miktar tayini limiti psödoefedrin için 16.17 μg / mL ve setirizin için 0.40 μg / mL idi. Yöntem geri kazanımı psödoefedrin için% 99.81 ± 0.60 ve setirizin için 100.08 ± 0.52 idi. Tekrarlanabilirlik ve ara hassasiyet açısından yöntem hassasiyeti, düşük nispi standart sapmalar (
Importance of Integrated Reporting, Climate Change Reporting & Environmental Management Accounting
Authors: O'Connell Brendan
Published: August 2022

This Seminar will inform participants about the ongoing changes in mandatory reporting requirements for organisations’ social, environmental and economic impacts as well as trends in voluntary reporting of these areas. We will also explore the key role played by management accountants in contributing to corporate social responsibility and its related reporting.
2021 ж. ортағасырлық Сарайшық қаласында жүргізілген археологиялық қазба жұмыстары
Authors: Ахметова Ұлжан Төлегенқызы , Тұрарұлы Айбек , Жұмабаев Амангелді
Published: August 2022

Мақалада 2021 ж. ортағасырлық Сарайшық қаласы орнында жүргізілген археологиялық жұмыстардың алдын-ала нәтижелері туралы айтылады. Сарайшықтың Ұлы Жібек жолында атқарған ролін жаңа ізденістермен толықтыру мақсатында зерттеу жұмыстары іске асырылуда. 2019 ж. басталған № 3 қазба орнындағы зерттеу одан әрі жалғастырылды. Қатарласа орналасқан бөлмелері, ұзын дәліздері бар алтынордалық кезеңнің ғимараты ашылып, құрылыс еденінен табылған Өзбек хан мен Жәнібек ханның соқтырған тиындары арқылы ХІV ғ. орта тұсымен кезеңделіп отыр. Бұрынғы зерттеулер көрсеткендей, қаланың мәдени қабаты түрлі жерленімдер, жаңа құрылыстар салынуы себепті бір-бірімен араласып кеткенімен, кейбір аудандардағы төменгі мәдени қабатта шикі кірпіштен тұрғызылған құрылыстар жақсы сақталған. Бұл алдын-ала жоспарланып жасалған түзу көшелерден, қатар орналасқан ғимараттардан қаланың аймақтағы дәрежесі жоғары екені байқалады. Қазбадан табылған материалдардың басым бөлігі қыш ыдыстар сынықтары мен жануарлар сүйектерінен тұрады. Мәдени қабаттың жәдігерлерге, әр түрлі бұйымдардың қалдықтарына бай болуы да, қаланың үлкен мәдени-саяси орталық болғанынан хабар береді.
Рецензия на книгу Георги Владимирова «Серьги в виде знака вопроса из средневековой Болгарии (XIII–XIV вв.): о материальных следах куманов и Золотой Орды в культуре Второго Болгарского царства» (Отв. ред. А.Г. Ситдиков, С.Г. Бочаров. Казань: ИА АН РТ, 2018)
Authors: Бисембаев Арман Ауганович
Published: August 2022

Рецензия на специализированную работу-каталог, посвященную изучению восточных влияний в культуре Второго Болгарского царства на Дунае в развитом и позднем средневековье (XII–XIV вв.). В качестве главного примера этих влияний рассматриваются серьги в виде знака вопроса – весьма распространенная категория украшений номадов, периода Золотой Орды Евразийского пояса степей. Автор рассматривает гипотезы их происхождения и распространения в средневековье как кочевнического типа моды, возникшей в культуре азиатских народов кимако-кыпчакского круга и распространившейся при их расселении на Балканах. В главе «Происхождение и распространение серег в виде знака вопроса» автором сделан краткий анализ распространения данных ювелирных изделий по крупным регионам – Поволжью, Западному, Центральному и Южному Казахстану, Забайкалью, Тянь-Шаню. Автором высказана мысль, что именно миграция поздних кочевников распространила моду на серьги в виде знака вопроса. Мода на данный вид украшений, получившая распространение в культуре Золотой Орды, приобрела надэтничный характер. Автором рецензируемой работы выдвинута гипотеза о том, что в XIII в. культурная и этническая картина в средневековой Болгарии «куманизируется», а в первой половине XIV в. даже «татаризируется». Данные процессы он противопоставляет прежней гипотезе о «византийском» влиянии в бассейне Дуная в начале II тысячелетия.
О традициях домостроительства эпохи бронзы в Жетысу (Казахстан)
Authors: Горячев Александр Анатольевич , Фрачетти Майкл Д.
Published: August 2022

В этой статье обобщаются результаты более чем 20-тилетних исследований поселений бронзового века в Жетысу. Целью работы является систематизация региональных культурных традиций и развитие материальной андроновской культуры на юго-востоке Казахстана с III по I тыс. до н.э. Обобщая результаты различных исследований, предложены предварительная карта памятников и описание характера заселения региона на различных этапах бронзового века. Данные о поселениях, задокументированные по всему Жетысу (Семиречье), демонстрируют, что предгорные районы были наиболее часто эксплуатируемой экологической нишей, а также областью, где сосредоточены крупнейшие поселения. Вслед за развитием поселений в горных и предгорных районах, степные равнины и полупустыни также были заселены на протяжении всего среднего и позднего бронзового веков. Землянки с каркасно-столбовой конструкцией были наиболее привычным типом жилья в культурных традициях андроновцев. Данные из Жетысу также показывают взаимосвязь между традициями домостроения и природными ресурсами и климатическими условиями отдельных жилых районов в Жетысу, Кунгей и Иле (Заилийский) Алатау, а также степных районах междуречья Шу-Иле. Существует два основных варианта жилищ с каменным и деревянным фундаментом. Большинство поселений, изученных в этот период, представляли собой жилища, предназначенные для средних и крупных жилых районов. В позднем бронзовом веке крупные поселения встречаются реже. На их месте есть ряд небольших поселений (до 4–5) с различными параметрами и планировкой жилищ. В бронзовом веке население Жетысу использовало сложный набор хозяйственных приемов, начиная от специализированного скотоводства и заканчивая смешанным (агро-скотоводство). Эта деятельность, как правило, связана с различными экологическими районами расселения, при этом агро-скотоводы преимущественно расселялись в предгорных зонах, а скотоводы – в высокогорных и равнинных. Выделение ремесленного производства в самостоятельную отрасль как в среде скотоводов, так и среди земледельцев способствовало активному товарообмену между ними, увеличению территорий охваченных хозяйственной деятельностью людей, и, как следствие, росту численности и благосостояния населения, что существенно усложняло социальную структуру племен эпохи бронзы Жетысу.