bluuebunny/crossref_metadata_2025 huggingface dataset:
Spatial analysis of soybean yield in the western mesoregion of Paraná using agrometeorological variables
Authors: Gabriel Caroline Cristina Engel , Uribe Opazo Miguel Angel , Dalposso Gustavo Henrique , Cima Elizabeth Giron
Published: February 2022

This paper aimed to analyze the spatial autocorrelation of soybean yield and its bivariate spatial correlation with theagrometeorological variables rainfall, mean temperature, and mean global solar radiation in 2014/2015, 2015/2016, and 2016/2017 crop years in the West of the State of Paraná – Brazil. To achieve this objective, techniques of spatial statistics of areas were used, which, through autocorrelation and spatial correlation indices, sought to identify patterns of association between soybean yield and agrometeorological variables. This research is justified because in addition to the soybean crop being the main source of food protein and vegetable oil in the world and the agrometeorological variables being the factors that most influence it, the western mesoregion of Paraná stands out with the highest production values in the state.  Thus, it is important to monitor its development through spatial analysis to obtain information that will support decision making. The global and local Moran’s indices showed that soybean yield is self-correlated in the municipalities of Western Paraná, identifying clusters to the west and east of the mesoregion. The significance of the bivariate spatial correlation indices confirmed the influence of the variables rainfall, mean temperature, and average global solar radiation on soybean yield.
Perfil profissional e sentimento de valorização dos médicos veterinários atuantes na assistência direta aos pacientes no município de Santa Maria/RS/Brasil
Authors: Veleda Patricia Alvez , Müller Daniel Curvello de Mendonça
Published: February 2022

Médicos veterinários são profissionais da saúde que se dedicam intensamente aos animais que cuidam, executando longas jornadas de trabalho e, por vezes, não tendo seu trabalho valorizado. O município de Santa Maria conta com uma rede de serviços veterinários composta por 2 hospitais, 25 clínicas e um total de 722 profissionais, até esta data, atuando na prevenção e manutenção da saúde dos animais. O objetivo deste estudo é descrever o perfil desses trabalhadores e verificar seu sentimento de valorização profissional. Para isso, foi realizada pesquisa descritiva por meio de questionário aplicado de maneira online, entre os meses de junho e julho de 2021. Participaram médicos veterinários atuantes na assistência direta aos pacientes do município. Entre os 120 profissionais avaliados, 72,5% eram mulheres, 48,3% estavam na faixa etária entre 20 e 30 anos, 57,5% solteiros, 70,9% exerciam atividades frente ao paciente a menos de 10 anos, 50% trabalhavam em hospital de instituição pública e 50% em instituições particulares ou atendimento domiciliar. Desses profissionais, 78,3% possuíam somente um vínculo empregatício, 49,2% atuavam com carga horária de trabalho semanal superior a 41h e 33,3% atendiam semanalmente mais de 15 pacientes. Observou-se muitos profissionais com sinais de esgotamento laboral. Dos entrevistados, 70% não se sentiam valorizados na profissão e 94,2% consideravam que o médico veterinário não é valorizado no Brasil, porém 62,5% não gostariam de exercer outra profissão, demonstrando satisfação em exercer a medicina veterinária.
Reabilitação oral de paciente com fissura labiopalatina: relato de caso
Authors: Rodrigues Célia Patrícia Müller , Pelizzoni Aline Vaneli , Brischke Jeani Aparecida Petrik , Kazmierski Scheila , Baltazar Mariângela Monteiro de Melo , Coelho Rejane Teixeira , Lima Daniela Pereira
Published: February 2022

A fissura labiopalatina é a anomalia craniofacial mais comum em seres humanos (1:650 nascimentos), sendo sua etiologia multifatorial. Os pacientes com essa condição são acometidos por desordens morfológicas e funcionais, dentre elas, má formações dentárias sendo a mais comum a agenesia, que ocorre com maior frequência nos incisivos laterais superiores permanentes do lado onde está a fenda, afetando a função, a estética e consequentemente a autoestima do paciente. O objetivo desse trabalho foi relatar o caso de um paciente fissurado com agenesia dentária, apresentar a alternativa utilizada para sua reabilitação e o impacto psicológico do tratamento. O paciente foi atendido no CEAPAC (Centro de Atenção e Pesquisa em Anomalias Craniofaciais) sendo sua queixa principal a agenesia dos incisivos laterais superiores, a placa de acrílico com dentes de estoque utilizada para reabilitação e a estética dos incisivos centrais superiores que se encontravam desalinhados e com alteração de forma. O plano de tratamento proposto foi a confecção de duas próteses fixas, tipo cantilever, envolvendo os incisivos centrais e os caninos superiores como apoio para o elemento suspenso, já que houve rejeição do enxerto e a instalação de implantes era inviável. A reabilitação dentária foi concluída de forma satisfatória, devolvendo ao paciente, dentro de suas limitações, não somente a função, como também a estética e autoconfiança, o paciente continuará em acompanhado para proservação clínica do caso. Ressalta-se a importância do atendimento por uma equipe multiprofissional especializada, considerando a complexidade da anomalia e a necessidade de reabilitação integral.
Neurociências e Educação, o papel da memória na dificuldade de aprendizagem: um estudo sobre as produções nos programas de pós-graduação no Brasil no período de 2011-2021
Authors: Reis Mariana Leal Tobias dos , Mori Nerli Nonato Ribeiro
Published: February 2022

Dificuldades de memória influenciam o processo de aprendizagem, visto que a capacidade de evocar o conhecimento ao longo do tempo e aplicá-lo é uma necessidade. O Brasil apresentou os piores escores em memória operacional e memória de curto prazo comparado a outras crianças de países como Itália, Inglaterra, Argentina e Canadá. Nesse sentido, a pesquisa buscou verificar como esse tema vem sendo pesquisado no Brasil. Para tanto, realizamos um levantamento dos trabalhos produzidos pelos programas de pós-graduação entre 2011 e 2021 e catalogados pela Biblioteca Digital Brasileira de Teses e Dissertações. Trata-se de uma pesquisa do tipo estado da arte, de cunho bibliográfico e documental e possui caráter descritivo. Após a leitura e análise dos resumos foram selecionadas 12 pesquisas, sendo 2 teses e 10 dissertações, destacando-se 2011 e 2016 como os anos de maior produção, somados 5(41,7%). Quanto à localização, há um predomínio na região Sudeste (58,3%), seguida pelo Sul (25%) e Nordeste (16,7%). Oito (8) dos trabalhos (66,7%) abordavam dificuldades relacionadas à memória operacional, e quanto às dificuldades de aprendizagem tratadas estão a leitura e compreensão, dislexia, Transtorno de Déficit de Atenção e discalculia e dificuldade em matemática, perfazendo um total de 8 (66,7%). As informações analisadas evidenciaram a importância da memória para a compreensão das dificuldades de aprendizagem, contudo no período de 10 anos encontrou-se poucas pesquisas que tratavam do assunto, indicando a necessidade de ampliação de estudos, bem como sua associação com neurociências para trilhar estratégias que auxiliem em planos pedagógicos focados em atender necessidades educacionais especiais.
Avaliação do potencial antimicrobiano dos extratos de fungos Penicillium spp.
Authors: Santiago Paulo Alexandre Lima , Santiago Sarah Raquel Silveira da Silva , Aquino Priscila Ferreira de , Nunomura Sergio Massayoshi , Nunomura Rita de Cássia Saraiva
Published: February 2022

Os fungos do gênero Penicillium produzem metabólitos secundários que são utilizados como modelo para a síntese e desenvolvimento de antibióticos como a Penicilina, Penicilina V, Ampicilina, Amoxilina e Griseofulvina. A produção de tais compostos pode ser explorada através de pequenas alterações em parâmetros físicos e químicos do cultivo. Essas alterações estimulam rotas biossintéticas silenciadas e isso aumenta a diversidade de compostos bioativos produzidos pelo fungo. Sendo assim, o objetivo do presente estudo foi de investigar o potencial antimicrobiano dos extratos Penicillium spp. isolados no estado do Amazonas. As linhagens estudadas nesse trabalho estão depositadas na Coleção de Fungos da Amazônia (CFAM) do Instituto Leônidas e Maria Deane (ILMD), e foram reativadas em meio BDA por sete dias. Para a produção dos extratos, utilizou-se uma solução de suspensão de esporos na concentração de 1 x 10-6 UFC/mL. Inoculou-se 50 µL desta suspensão em erlenmeyers contendo 25 mL dos meios BDL, SB, YES e ISP2.O experimento foi realizado em triplicata, em modo estático, incubado à 28 ºC por 15 dias. Passado esse período, o caldo fermentado foi extraído com acetato de etila e o micélio com metanol. Então, determinou-se a Concentração Mínima Inibitória – CIM dos extratos obtidos em acetato de etila frente aos patógenos Candida albicans, Candida tropicalis, Escherichia coli, Pseudomonas aeruginosa, Enterococcus faecalis e Staphylococcus aureus. As melhores atividades foram observadas para as linhagens P. oxalicum e P. citrinum cultivados em BDL e SB com CIM de 250 µg/ml e 62,5 µg/ml, respectivamente.
O impacto da pandemia SARS-CoV-2 no marketing da enfermagem: uma revisão integrativa
Authors: David Marcos José Vilchez , Oliveira Juliana Lana Querino de , Silva Maria Virginia Godoy da , Silva Leandro Andrade da , Silva Roni Robson da , Neves Milena Preissler das
Published: February 2022

A pandemia pelo SARS-Cov-2 assombra o planeta desde o ano de 2020, dizimando milhares de pessoas em todo o mundo. Esse momento poderia ser propício para que o mundo reconhecesse o valor dos profissionais de saúde, do enfermeiro e da Enfermagem. Objetivo: Analisar as produções científicas sobre o impacto da pandemia pela SARS-Cov-2 no marketing da Enfermagem. Metodologia: Revisão integrativa da literatura, de acordo com a estratégia PICo e procedimentos definidos pelo Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Bases de dados consultadas: Assia_Coronavírus; BVS; CINAHIL; Embase; PubMed; SciELO; Scopus e WOS. Resultados: Onze estudos foram selecionados para análise.  A Enfermagem ganhou holofotes pela atuação. Os profissionais de enfermagem tiveram pouco acesso a Equipamentos de Proteção Individual (EPIs) adequados; faltaram espaços e recursos apropriados para a assistência e um subdimensionamento das equipes. O Brasil liderou o ranking mundial de óbitos de profissionais de enfermagem. O não reconhecimento do poder da profissão; altas jornadas de trabalho, salários baixos, resultam na desvalorização do trabalho do próprio enfermeiro Conclusão: Durante a pandemia pela SARS-CoV-2, a Enfermagem esteve na linha de frente, o que possibilitou de certa forma maior visibilidade profissional. As condições de trabalho desfavoráveis, baixos salários e outros desafios enfrentados pelos profissionais de enfermagem sinalizam que a profissão ainda carece de reconhecimento e que esforços para o marketing favorável precisam ser empenhados.
Crambe grain yield affected by compaction degrees of an Oxisol
Authors: Marins Araceli Ciotti de , Reichert José Miguel , Secco Deonir , Bassegio Doglas , Nava Daniela Trentin
Published: February 2022

Crambe is a new crop that produces oil used for biodiesel production. Soil compaction in a no-tillage (NT) system is one of the main challenges for sustainable grain production in soil clay. The objective of this study was to evaluate the effect of compaction degree on crambe grain yield over two years. The levels of artificial compaction were generated using a roller compactor (0, 1, 3, and 5 passes) under a NT system. The experimental design was a strip block, and soil density and crambe grain yield were evaluated. The passes of the roller increased the density from 0.98 to 1.24 Mg m−3 in the 0–0.1 m layer, and 1.03 to 1.15 Mg m−3 in the 0.1–0.2 m layer. As a result, the compaction degree increased from 53% to 66% in the 0–0.1 m layer and 54% to 61% in the 0.1–0.2 m layer. Five passes of the roller compactor reduced the crambe grain yield by 41% and 9% in the first and second years, respectively, compared to the NT system without additional compaction. The crambe grain yield was reduced when the compaction degree reached 53%; therefore, crambe is not suitable for compacted soils.
Higher Order Thinking Questions in Teaching Reading in a Private Primary School
Authors:   Xin Zhong School Indonesia, Mintre Rosalinda , Lie Anita ,   Widya Mandala Catholic University, Surabaya Indonesia
Published: February 2022

In order to meet up the needs of acquiring the 21st century skills, students need to be equipped with critical thinking skills. In English language learning, one way to foster students’ critical thinking is through Higher Order Thinking (HOT) questions in reading. This study unveils the implementation of HOT questions in Grade 5 reading classes in a private primary school in Surabaya. The study in particular was aimed to find out (1) the structure of the teacher’s questions, (2) the types of the teacher’s questions, and (3) the students’ responses. This study used the New Bloom’s taxonomy as the underlying instrument for classifying the types of questions and the students’ responses. Four class observations, four teacher’s interviews and two students’ focus group discussions were conducted in this study. The recorded data were transcribed and analyzed to get the results. The results of the data analysis indicate that 65.15% of the total of 66 questions used by the teacher in the classroom were HOT questions. Among all types of HOT questions, the New Bloom’s analyze questions were used the most with 37.88% of the total questions. HOT questions were mostly addressed during the whilst-instructional activities. Interestingly, the HOT questions were answered in different forms: oral answers, dramatizations and presentations. Related to this finding, the teacher was quite satisfied with the students’ responses since they reached the same thinking level, although sometimes it is necessary for the teacher to simplify his questions in order to get students’ responses.
Metacognitive Strategies in Teaching Reading to Primary Students
Authors:   Widya Mandala Catholic University Surabaya Indonesia, Tandean Diana
Published: February 2022

This study is aimed to cater to the needs of professionals in raising young learners’ awareness of their own reading comprehension, educators can implement metacognitive strategy as one of the solutions. Therefore this study aims to know the effectiveness of metacognitive strategy in teaching reading to primary students. The grand theory employed in this study is the six sequential reading strategies proposed by Brown, Palinscar and Armbruster’s (1984). The research method is pre-experimental study with three groups of third graders as the participants. The researcher designed a reading assignment for each treatment, as well as a reading test as the research instrument. The pre-test and post-test data was analyzed using paired t-test. The data shows a significant difference between pre-test and post-test scores among all three groups.
Using the VEMCO Positioning System (VPS) to explore fine-scale movements of aquatic species: applications, analytical approaches and future directions
Authors: Orrell DL , Hussey NE
Published: February 2022

Recent advancements in telemetry have redefined our ability to quantify the fine-scale movements of aquatic animals and derive a mechanistic understanding of movement behaviours. The VEMCO Positioning System (VPS) is a fine-scale commercial positioning system used to generate highly accurate semi-continuous animal tracks. To date, VPS has been used to study 86 species, spanning 25 taxonomic orders. It has provided fine-scale movement data for critical life stages, from tracking day-old turtle hatchlings on their first foray into the sea to adult fish returning to natal rivers to spawn. These high-resolution tracking data have improved our understanding of the movements of species across environmental gradients within rivers, estuaries and oceans, including species of conservation concern and commercial value. Existing VPS applications range from quantifying spatio-temporal aspects of animal space use and key aspects of ecology, such as rate of movement and resource use, to higher-order processes such as interactions among individuals and species. Analytical approaches have seen a move towards techniques that incorporate error frameworks such as autocorrelated kernel density estimators for home range calculations. VPS technology has the potential to bridge gaps in our fundamental understanding of fine-scale ecological and physiological processes for single and multi-species studies under natural conditions. Through a systematic review of the VPS literature, we focus on 4 principle topics: the diversity of species studied, current ecological and ecophysiological applications and data analysis techniques, and we highlight future frontiers of exploration.
Akdeniz Üniversitesi Turizm Fakültesi Öğrencilerinin Destinasyon Seçiminde Etkili Olan Çekici Faktörlerin Önem Performans Analizi
Authors: AKINCI Zeki , AYBAR Dilek , DEMİREL Altan , BAHTİYAR SARI Dilara , ÖKSÜZ Emine Nurdan
Published: February 2022

Yoğun küresel rekabetin yaşandığı günümüz turizm sektöründe, turistik destinasyonların tercih edilmesinde, destinasyonların sahip oldukları çekici faktörlerin önemli bir etkisi bulunmaktadır. Bu çalışmada, Antalya ilinde bulunan Akdeniz Üniversitesi’nde turizm eğitimi alan 426 öğrenciden anket tekniği ile veriler toplanmış ve Önem-Performans Analizi (ÖPA) yöntemiyle destinasyonda algılanan çekici faktörlerin önemi ve çekici faktörlerin uygulanma performansları tespit edilmesi amaçlanmıştır. Elde edilen sonuçlara göre, yüksek önem ve yüksek performans gösterilen doğal güzellikler, kültür, konaklama hizmetleri ve destinasyonun cazip alanları destinasyonun korunması ve sürdürülmesi gereken yönleri olarak; buna karşılık hem düşük önem hem de düşük performans gösterilen destinasyon danışma hizmetleri, destinasyondaki yerlere sınırsız ziyaret, bilgilendirici levha ve simgeler, ilginç/farklı yerel gelenekler düşük öncelik verilmesi gereken; yoğunlaşılması gereken özellikler olarak ulaşma ağının yaygınlığı, destinasyonun temizliği, yiyecek-içecek işletmelerin kalitesi; düşük önem verilmesine rağmen yüksek performans gösterilen ve kaçınılması gereken özellikler ise iş/ticaret, destinasyonun tarihi ve birden çok alışveriş fırsatı olarak saptanmıştır.
Pertumbuhan Eucheuma denticulatum Berdasarkan Kedalaman Yang Dipelihara Dengan Metode Vertinet
Authors: Mursalim Ode , Ruslaini Ruslaini , Kasim Ma’ruf
Published: February 2022

Penelitian ini bertujuan untuk mengetahui laju pertumbuhan E. denticulatum terhadap kedalaman berbeda yang dibudidayakan dengan metode vertinet dan pengaruh parameter kualitas air terhadap pertumbuhan E. denticulatum yang dipelihara dengan kedalaman yang berbeda. Penelitin ini dilaksanakan pada bulan November-Desember 2019 yang bertempat di perairan Pantai Lakeba Kota Bau-Bau, Sulawesi Tenggara. Penelitian ini menggunakan metode Rancangan Acak Lengkap (RAL) di mana terdiri dari 3 perlakuan dan 27 ulangan individu yakni perlakuan A (kedalaman 30 cm), perlakuan B (kedalaman 40 cm) dan perlakuan C (kedalaman 50 cm) dengan berat awal rumput laut 20 gram.  Hasil penelitian menunjukkan bahwa laju pertumbuhan spesifik perlakuan A 3,74% perhari, perlakuan B 3,71% perhari dan perlakuan C 3,94% perhari. Hasil pengukuran parameter kualitas air menunjukkan bahwa kualitas air di lokasi penelitian masih dalam kisaran toleransi untuk pertumbuhan rumput laut E. denticulatum. Penelitian ini menyimpulkan bahwa E. denticulatum yang dipelihara dengan metode vertinet memiliki laju pertumbuhan spesifik yang baik yaitu lebih dari 3% perhari. Semakin dalam bibit E. denticulatum diletakkan dalam perairan maka pertumbuhan E. denticulatum semakin rendah. Kualitas air dapat mempengaruhi pertumbuhan E. denticulatum terutama pada parameter fosfat, nitrat dan salinitas. Kata Kunci : Kedalaman air laut, Vertinet, pertumbuhan rumput laut Eucheuma denticulatum
PENGENDALIAN PERSEDIAAN DENGAN MENGGUNAKAN METODE CONTINUOUS REVIEW SYSTEM DAN METODE PERAMALAN PADA PT XYZ
Authors: Prihandoko Danang , Tanadjaya Nexia , Chendrawaty Christine
Published: February 2022

This study aims to determine the optimal number of orders, estimated costs, reorder points, and safety stock. This study uses quantitative methods and aims to provide inventory control proposals using Continuous Review System analysis and Forecasting with QM software for windows. So as to obtain optimal order results A3 + Glossy 8060 pack stickers with a cost of Rp. 545,508,208.43. A3 + Matte stickers 3,238 pack with a fee of Rp 237,554,470.91. A3 + Transprent 4,181 pack stickers at a cost of Rp. 294,737,067.25. Furthermore, a Reorder Point point of 1,520 packs for Glossy, 687 packs for Matte, and 732 packs for Transparent and Safety Stock Level for Glossy of 189 packs was obtained. Matte of 117 packs, Transparent of 97 packs. Based on the results of these calculations it can be concluded that using the Continuous Review System method can control inventory and estimate the cost to be incurred more effectively and efficiently by the company. (NT, CC, JK)
PENGARUH KOMPETENSI DAN INTEGRITAS TERHADAP KINERJA PENYULUH PERTANIAN YANG DIMEDIASI OLEH KEPUASAN KERJA PADA DINAS TANAMAN PANGAN, HOLTIKULTURA DAN PERKEBUNAN (TPHP) KAB. KONAWE
Authors: Syahruni Siti , Syaifuddin Dedy Takdir , Adam La Ode Bahana , Nur Nofal , Kohawan Muh. Rivan , Hasan Rachmat Riyaldi
Published: February 2022

Penelitian ini untuk menguji dan membuktikan secara empiris pengaruh kompetensi,integritas dan kepuasan kerja sebagai variabel mediasi terhadap kinerja penyuluh pada Dinas Tanaman Pangan, Holtikultura dan perkebunan (TPHP) Kabupaten Konawe.Penelitian ini merupakan Penelitian explanatory yang bertujuan menjelaskan Hubungan kausal antar variabel dengan  menggunakan pendekatan kuantitatif. Populasi dan sampel dalam Penelitian ini adalah seluruh penyuluh pada Dinas Tanaman Pangan, Holtikultura dan perkebunan (TPHP) Kabupaten Konawe 130 orang responden. Metode analisis untuk menjawab hipotesis dalam penelitian ini adalah Metode PLS (Partial Least Square)yang mengukur intensitas 3 variabel, yaitu variabel independen, variabel mediasi dan variabel dependen.Hasil Penelitian menunjukkan bahwa kompetensi, integritas secara parsial berpengaruh positif dan signifikan terhadap kepuasan kerja penyuluh pada Dinas Tanaman Pangan, Holtikultura dan perkebunan (TPHP) Kabupaten Konawe. Kepuasan kerja berpengaruh positif dan signifikan terhadap kinerja penyuluh pada Dinas Tanaman Pangan, Holtikultura dan perkebunan (TPHP) Kabupaten Konawe. Kompetensi secara parsial berpengaruh negatif dan tidak signifikan terhadap kinerja penyuluh pada Dinas Tanaman Pangan, Holtikultura dan perkebunan (TPHP) Kabupaten Konawe sedangkan integritas secara parsial berpengaruh positif dan  signifikan terhadap kinerja penyuluh pada Dinas Tanaman Pangan, Holtikultura dan perkebunan (TPHP) Kabupaten Konawe. Untuk Variabel kepuasan kerja memediasi full antara kompetensi dan integritas terhadap kinerja penyuluh pada Dinas Tanaman Pangan, Holtikultura dan perkebunan (TPHP) Kabupaten KonaweKata Kunci:     Kompetensi, integritas, kepuasan kerja Dan Kinerja Penyuluh
PENGARUH LINGKUNGAN KERJA, KOMITMEN ORGANISASI DAN MOTIVASI KERJA TERHADAP KINERJA GURU DI SMA NEGERI 1 GU KABUPATEN BUTON TENGAH
Authors: Alimin Alimin , Hakim Adnan , Nasrul Nasrul , Mokodompit Eliyanti Agus , Sabri Sabri
Published: February 2022

This study aims to explain and examine: (1) the effect of the work environment, organizational commitment, and work motivation on teacher performance, (2) the effect of the work environment on teacher performance, (3) the effect of organizational commitment on teacher performance, and (4) the effect of work motivation on teacher performance. This research approach is survey with explanatory research design.  Data collection was carried out in a cross-sectional manner using an instrument in the form of a questionnaire. The population in this study were all 53 teachers of SMA Negeri 1 Gu. The sampling technique is a saturated sample (census) where the entire population is used as the research sample. Data analysis techniques to answer the research hypothesis are descriptive and multiple linear regression. The results showed that: (1) work environment, organizational commitment, and work motivation simultaneously had a significant effect on teacher performance, (2) work environment had a significant effect on teacher performance, (3) organizational commitment had a significant effect on teacher performance, (4) work motivation has a significant effect on teacher performance. Keywords: Work Environment, Organizational Commitment, Work Motivation Teacher Performance.
ANALISIS FAKTOR YANG MEMPENGARUHI PENYERAPAN ANGGARAN SATUAN KERJA PENGGUNA APBN TAHUN 2021 DI SULAWESI TENGGARA (Analysis of Affecting Factors on Budget Absorption of The Working Unit Users of APBN 2021 in Southeast Sulawesi)
Authors: Pramesti Muhammad Teguh
Published: February 2022

This research indentify and analyze factors that influence the absorption of rate of goods expenditure budget management working units of APBN users in Sulawesi Tenggara. The population of this research is the working units of APBN users in Sulawesi Tenggara. Working units who participate is 223 users by filling the online questionnaire deployed through the online. Data analyzed by using Exploratory Factor Analysis (EFA) method with SPSS 25 application. The result of this research are six factors that influence the low absorption of the spending, they are the factor of budget implementation, procurement of goods, the use of fund, ineffective planning, the impact of COVID-19 pandemic, dan geographical. The sum of variance that explained those factors is 62.493%, and the remaining 37.507% explained by other factors.
OPTIMIZATION OF TROLLEYBUS TRACTION BATTERY PARAMETERS WHEN PARTIAL AUTONOMOUS RUNNING
Authors: Andrusenko Serhiy , Podpisnov Vladyslav
Published: February 2022

The article describes the method of determining the optimal capacity of the traction battery of a trolleybus with autonomous travel depending on the share of the route without a catenary. In modern cities, there is often a situation in which on some sections of trolleybus routes for various reasons there is no contact network for trolleybus traffic. The solution to the problem of ensuring the movement of trolleybuses on such routes may be the use of autonomous trolleybuses, which use the energy of the traction battery (TAB). The battery may be partially or fully recharged while the trolleybus is running on mains power. In case of incomplete charging of the battery while driving on the route, the TAB can receive a full charge during the sludge of the trolleybus in the park after the change at the night rate, which is usually less than the day rate for electricity. The optimal capacity of the traction battery in such conditions corresponds to the minimum cost of energy and equipment for trolleybus traffic, depends on the size of the route without a catenary, the physical capacity of the network to charge the battery, and the ratio of day and night electricity tariffs. Determining the optimal capacity of TAB for operation on routes where there is no contact network is an important task. The article shows that the minimum capacity of the TAB Етаб should be such as to ensure the movement of the trolleybus on the site without a catenary. In this case, there is a value of the share of the route without a catenary, at which the TAB can be fully charged from the network when moving on the section with the network. Further, when increasing the share of the route without a catenary, the TAB of the trolleybus needs to be recharged either at the end of the route or after the change in the depot or sludge point and a corresponding increase in the required capacity of the TAB by the amount of undercharging. In this case, it may be more cost-effective to charge the TAB using the night rate, which is usually much lower than the day rate. It is determined that in terms of the cost of electricity per movement when charging TAB at the night rate, the use of an electric bus can be more cost-effective compared to an autonomous trolleybus, especially in the complete absence of a catenary. The method does not take into account energy losses in accordance with the factors of operation climatic conditions as well as the efficiency of chargers and associated automatic control, the design possibility of energy recovery on the route, the load of the trolleybus during the work shift, which requires a separate study. The results of the article can be used when autonomous trolleybuses production. Projected assumptions about the development of the object of study – further research should be aimed at a detailed study of the impact of all components of the vehicle on the cost of its operation in different conditions.
Identification of the Expression Patterns and Potential Prognostic Role of 5-Methylcytosine Regulators in Hepatocellular Carcinoma
Authors: Liu Yong , Zheng Shunzhen , Wang Tao , Fang Ziqi , Kong Junjie , Liu Jun
Published: February 2022

Background: Hepatocellular carcinoma (HCC) is the most common primary liver cancer with a poor prognosis. 5-methylcytosine (m5C) modification plays a nonnegligible role in tumor pathogenesis and progression. However, little is known about the role of m5C regulators in HCC.

Methods: Based on 9 m5C regulators, the m5C modification patterns of HCC samples extracted from public databases were systematically evaluated and correlated with tumor immune and prognosis characteristics. An integrated model called the “m5Cscore” was constructed using principal component analysis, and its prognostic value was evaluated.

Results: Almost all m5C regulators were differentially expressed between HCC and normal tissues. Through unsupervised clustering, three different m5Cclusters were ultimately uncovered; these clusters were characterized by differences in prognosis, immune cell infiltration, and pathway signatures. The m5Cscore was constructed to quantify the m5C modifications of individual patients. Subsequent analysis revealed that the m5Cscore was an independent prognostic factor of HCC and could be a novel indicator to predict the prognosis of HCC.

Conclusion: This study comprehensively explored and systematically profiled the features of m5C modification in HCC. m5C modification patterns play a crucial role in the tumor immune microenvironment (TIME) and prognosis of HCC. The m5Cscore provides a more holistic understanding of m5C modification in HCC and provides a practical tool for predicting the prognosis of HCC. This study will help clinicians identify effective indicators of HCC to improve the poor prognosis of this disease.
Tris(2-Pyridylmethylamine)V(O)2 Complexes as Counter Ions of Diprotonated Decavanadate Anion: Potential Antineoplastic Activity
Authors: Corona-Motolinia Nidia D. , Martínez-Valencia Beatriz , Noriega Lisset , Sánchez-Gaytán Brenda L. , Melendez Francisco J. , García-García Amalia , Choquesillo-Lazarte Duane , Rodríguez-Diéguez Antonio , Castro María Eugenia , González-Vergara Enrique
Published: February 2022

The synthesis and theoretical-experimental characterization of a novel diprotanated decavanadate is presented here due to our search for novel anticancer metallodrugs. Tris(2-pyridylmethyl)amine (TPMA), which is also known to have anticancer activity in osteosarcoma cell lines, was introduced as a possible cationic species that could act as a counterpart for the decavanadate anion. However, the isolated compound contains the previously reported vanadium (V) dioxido-tpma moieties, and the decavanadate anion appears to be diprotonated. The structural characterization of the compound was performed by infrared spectroscopy and single-crystal X-ray diffraction. In addition, DFT calculations were used to analyze the reactive sites involved in the donor-acceptor interactions from the molecular electrostatic potential maps. The level of theory mPW1PW91/6–31G(d)-LANL2DZ and ECP = LANL2DZ for the V atom was used. These insights about the compounds’ main interactions were supported by analyzing the noncovalent interactions utilizing the AIM and Hirshfeld surfaces approach. Molecular docking studies with small RNA fragments were used to assess the hypothesis that decavanadate’s anticancer activity could be attributed to its interaction with lncRNA molecules. Thus, a combination of three potentially beneficial components could be evaluated in various cancer cell lines.
Using a Systems Approach to Explore the Mechanisms of Interaction Between Severe Covid-19 and Its Coronary Heart Disease Complications
Authors: Meyer Albertus A. , Mathews Edward H. , Gous Andries G. S. , Mathews Marc J.
Published: February 2022

Frontiers requested research on how a systems approach can explore the mechanisms of cardiovascular complications in Covid-19. The focus of this paper will thus be on these detailed mechanisms. It will elucidate the integrated pathogenic pathways based on an extensive review of literature. Many severe Covid-19 cases and deaths occur in patients with chronic cardiovascular comorbidities. To help understand all the mechanisms of this interaction, Covid-19 complications were integrated into a pre-existing systems-based coronary heart disease (CHD) model. Such a complete model could not be found in literature. A fully integrative view could be valuable in identifying new pharmaceutical interventions, help understand how health factors influence Covid-19 severity and give a fully integrated explanation for the Covid-19 death spiral phenomenon seen in some patients. Covid-19 data showed that CHD hallmarks namely, Hypercoagulability, Hypercholesterolemia, Hyperglycemia/Hyperinsulinemia, Inflammation and Hypertension have an important effect on disease severity. The pathogenic pathways that Covid-19 activate in CHD were integrated into the CHD model. This fully integrated model presents a visual explanation of the mechanism of interaction between CHD and Covid-19 complications. This includes a detailed integrated explanation of the death spiral as a result of interactions between Inflammation, endothelial cell injury, Hypercoagulability and hypoxia. Additionally, the model presents the aggravation of this death spiral through the other CHD hallmarks namely, Hyperglycemia/Hyperinsulinemia, Hypercholesterolemia, and/or Hypertension. The resulting model further suggests systematically how the pathogenesis of nine health factors (stress, exercise, smoking, etc.) and seven pharmaceutical interventions (statins, salicylates, thrombin inhibitors, etc.) may either aggravate or suppress Covid-19 severity. A strong association between CHD and Covid-19 for all the investigated health factors and pharmaceutical interventions, except for β-blockers, was found. It is further discussed how the proposed model can be extended in future to do computational analysis to help assess the risk of Covid-19 in cardiovascular disease. With insight gained from this study, recommendations are made for future research in potential new pharmacotherapeutics. These recommendations could also be beneficial for cardiovascular disease, which killed five times more people in the past year than Covid-19.
Relevance of Cor Pulmonale in COPD With and Without Pulmonary Hypertension: A Retrospective Cohort Study
Authors: Yogeswaran Athiththan , Kuhnert Stefan , Gall Henning , Faber Marlene , Krauss Ekaterina , Rako Zvonimir A. , Keranov Stanislav , Grimminger Friedrich , Ghofrani Hossein Ardeschir , Naeije Robert , Seeger Werner , Richter Manuel J. , Tello Khodr
Published: February 2022

Background

The relevance of cor pulmonale in COPD and pulmonary hypertension due to COPD (PH-COPD) is incompletely understood. We aimed to investigate the relationship of right ventricular-pulmonary arterial (RV-PA) uncoupling with disease severity in COPD, and the relationship of RV-PA uncoupling and use of targeted PH therapies with mortality in PH-COPD.

Methods

We retrospectively analyzed 231 patients with COPD without PH and 274 patients with PH-COPD. COPD was classified according to GOLD stages and the modified Medical Research Council dyspnoea scale. PH was categorized as mild-to-moderate or severe. RV-PA uncoupling was assessed as the echocardiographic tricuspid annular plane systolic excursion/pulmonary artery systolic pressure (TAPSE/PASP) ratio.

Results

Of the cohort with COPD without PH, 21, 58, 54 and 92 were classified as GOLD I, II, III and IV, respectively. Patients in advanced GOLD stages and those with severe dyspnoea showed significantly decreased TAPSE/PASP.

Of the PH-COPD cohort, 144 had mild-to-moderate PH and 130 had severe PH. During follow-up, 126 patients died. In univariate Cox regression, TAPSE/PASP and 6-min walk distance (6MWD; 10 m increments) predicted survival [hazard ratios (95% CI): 0.12 (0.03–0.57) and 0.95 (0.93–0.97), respectively]; notably, PH severity and simplified European Society of Cardiology/European Respiratory Society risk stratification did not. Among patients in the lowest or intermediate tertiles of TAPSE/PASP and 6MWD, those with targeted PH therapy had higher survival than those without (53 vs. 17% at 3 years).

Conclusion

Cor pulmonale (decreased TAPSE/PASP and 6MWD) is associated with disease severity in COPD and predicts outcome in PH-COPD.
Improving Left Atrial Appendage Occlusion Device Size Determination by Three-Dimensional Printing-Based Preprocedural Simulation
Authors: Kim William D. , Cho Iksung , Kim Young Doo , Cha Min Jae , Kim Sang-Wook , Choi Young , Shin Seung Yong
Published: February 2022

Background

The two-dimensional (2D)-based left atrial appendage (LAA) occluder (LAAO) size determination by using transesophageal echocardiography (TEE) is limited by the structural complexity and wide anatomical variation of the LAA.

Objective

This study aimed to assess the accuracy of the LAAO size determination by implantation simulation by using a three-dimensional (3D)-printed model compared with the conventional method based on TEE.

Methods

We retrospectively reviewed patients with anatomically and physiologically properly implanted the Amplatzer Cardiac Plug and Amulet LAAO devices between January 2014 and December 2018 by using the final size of the implanted devices as a standard for size prediction accuracy. The use of 3D-printed model simulations in device sizing was compared with the conventional TEE-based method.

Results

A total of 28 cases with the percutaneous LAA occlusion were reviewed. There was a minimal difference [−0.11 mm; 95% CI (−0.93, 0.72 mm); P = 0.359] between CT-based reconstructed 3D images and 3D-printed left atrium (LA) models. Device size prediction based on TEE measurements showed poor agreement (32.1%), with a mean difference of 2.3 ± 3.2 mm [95% CI (−4.4, 9.0)]. The LAAO sizing by implantation simulation with 3D-printed models showed excellent correlation with the actually implanted LAAO size (r = 0.927; bias = 0.7 ± 2.5). The agreement between the 3D-printed and the implanted size was 67.9%, with a mean difference of 0.6 mm [95% CI (−1.9, 3.2)].

Conclusion

The use of 3D-printed LA models in the LAAO size determination showed improvement in comparison with conventional 2D TEE method.
An Experimental Study on the Scalability of Recent Node Centrality Metrics in Sparse Complex Networks
Authors: Freund Alexander J. , Giabbanelli Philippe J.
Published: February 2022

Node centrality measures are among the most commonly used analytical techniques for networks. They have long helped analysts to identify “important” nodes that hold power in a social context, where damages could have dire consequences for transportation applications, or who should be a focus for prevention in epidemiology. Given the ubiquity of network data, new measures have been proposed, occasionally motivated by emerging applications or by the ability to interpolate existing measures. Before analysts use these measures and interpret results, the fundamental question is: are these measures likely to complete within the time window allotted to the analysis? In this paper, we comprehensively examine how the time necessary to run 18 new measures (introduced from 2005 to 2020) scales as a function of the number of nodes in the network. Our focus is on giving analysts a simple and practical estimate for sparse networks. As the time consumption depends on the properties in the network, we nuance our analysis by considering whether the network is scale-free, small-world, or random. Our results identify that several metrics run in the order ofO(nlogn) and could scale to large networks, whereas others can requireO(n2) orO(n3) and may become prime targets in future works for approximation algorithms or distributed implementations.
Influence of Crack Spacing/Layer Thickness Value on Reflection Crack Propagation Mechanism Under Low Temperatures
Authors: Bao Chunyan , Liu Qi , Xia Yingjie , Cui Yi , Cao Zongyong , Qian Yidong , Liu Minghao , Mu Chaoqian , Wang Hongliang
Published: February 2022

The damage of asphalt concrete pavement (AC pavement) structure caused by reflection crack is an urgent problem in many areas of China, especially in cold regions of China, so it is necessary to study how to reduce the reflective cracking and prevent the AC pavement structures cracking. The acoustic emission (AE) information is fetched in this paper to study the AE characteristics of pavement structures and the crack propagation law inside the system. On the above basis, cracks with crack spacing/layer thickness values of 1.25, 2.5, 3.75, and 5 were prefabricated in the foundation course by the numerical simulation method. The models with different foundation course crack spacing were calculated by Realistic Failure Process Analysis finite element software. The influence of varying crack spacing on the propagation mechanism of reflective cracks in the foundation course structure was studied. The results show that the AC pavement structure has prominent AE characteristics. The faster the cooling rate is, the more serious the damage to the AC pavement surface is. In addition, with the increase of crack spacing/layer thickness value, the stress level between cracks increases continuously. Most of the stress will make the cracks expand toward the foundation course structure, and only a tiny part of stress is used to form reflective cracks. In practical engineering, it is suggested to increase the crack resistance of foundation course materials and preset some small spacing cracks in the large spacing cracks in the foundation course.
Research on the Stability of Shallow-Buried Large Cross-Section Tunnel by Construction Method Conversion
Authors: Zhang Zhiyong , Zhao Chenyang , Peng Long , Zhang Xiaohui , Lei Mingfeng
Published: February 2022

The blind and random use of the combined construction method may have a great impact on tunnel stability. To determine the influence of construction method conversion on tunnel deformation and the reasonable conversion condition, a numerical model is established to simulate the construction method transforms from central diaphragm method to the benching tunneling method based on Jiaoweiqin Tunnel. The conversion condition is determined based on the results of tunnel geological prediction and in-site monitoring, and the temporary two-bench tunneling method is adopted to ensure the success of construction method conversion. Besides, the parameter analysis is done to analyze the influence of mechanical properties of surrounding rock mass and bench length on tunnel stability. Research results indicate that the construction safety should be evaluated before construction method conversion is carried out by analyzing the design blueprint, tunnel geological prediction results, geological survey reports, rock mass conditions in front of tunnel face, in-site monitoring data, and numerical simulation results. Meanwhile, the construction method conversion can be carried out in the order of central diaphragm method, two-bench tunneling method, and bench tunneling method. Parameter analysis results reveal that the deformation of primary support decreases in a negative exponential form with the increase in elasticity modulus and increases approximately linearly with the increase in bench length. For shallow buried and large cross-section tunnels, the tunnel deformation is in a small state when the elastic modulus of rock mass reaches a certain value. The construction method conversion can be carried out when the rock mass has a certain stability, and the length of construction method conversion should be small to ensure construction safety.
Students’ Perceptions of Excellence in Chilean High-Performing Public Schools
Authors: Quaresma Maria Luísa , Allende Claudio , Villalobos Cristóbal , Araneda Sebastián
Published: February 2022

This paper aims to analyze how students attending six of the most prestigious, selective, and high-performing public schools in Chile perceive the concept of excellence and what factors influence their perceptions. A survey was administered to 1,828 students enrolled in 11thand 12thgrade. The results show that students share a multidimensional idea of excellence. Five dimensions are identified but, according to students’ perceptions, there were two constructs that stood out the most: “effort and self-improvement’” and ‘”social commitment and thoughtfulness.” We find that variables such as expectations about the future and perceptions about schools explain the dissimilar ideas of excellence shared by students. This research gives voice to students on a current topic of the educational agenda –the concept of excellence– and invites researchers to re-think this construct from perspectives other than academic achievements
The Russian Registry of Chronic Hypoparathyroidism
Authors: Kovaleva Elena V. , Eremkina Anna K. , Elfimova Alina R. , Krupinova Julia A. , Bibik Ekaterina E. , Maganeva Irina S. , Gorbacheva Anna M. , Dobreva Ekaterina A. , Melnichenko Galina A. , Mokrysheva Natalia G.
Published: February 2022

Introduction

Chronic hypoparathyroidism is a relatively rare disease associated with multicomponent medical therapy and various complications. The analysis of large databases of patients with chronic hypoparathyroidism is a necessary tool to enhance quality of medical care, as well as to determine the optimal clinical and therapeutic approaches, and prognostic markers of the disease.

The Aim

of this study is to estimate the clinical and biochemical profile, long-term complications, medical therapy and disease control of the patients with chronic postsurgical and non-surgical hypoparathyroidism.

Materials and Methods

the cross-sectional, observational, continuous study was based on the Russian Registry of patients with hypoparathyroidism. 544 patients from 63 regions of the Russian Federation were included in this study.

Results

The majority of cases had postsurgical etiology (88.4%). Postsurgical hypoparathyroidism prevailed in females (р<0.001). About a half of patients had blood calcium and phosphorus targets, 56 and 52% respectively. Nephrolithiasis was confirmed in 32.5%, nephrocalcinosis - in 12.3% of cases. The risk of nephrocalcinosis/nephrolithiasis increased by 1.85 times with disease duration more than 4.5 years. The cataract was found in 9.4%. The cut-off point for the development of cataracts was 9.5 years, with a 6.96-fold increased risk. The longer duration of hypoparathyroidism of any etiology was associated with more frequent cataract (p=0.0018).We found brain calcification in 4%, arrhythmias in 7.2% and neuropsychiatric symptoms in 5.15% of cases. Generally, the BMD in the studied group corresponded to age values, and there was no evidence for the phenomenon of high bone density. TBS was consistent with normal bone microarchitectonics. In our study, the majority of patients (83.5%) was treated with standard therapy of calcium and vitamin D supplements. 5 patients with severe disease course were treated with rhPTH (1–34).

Conclusions

Analysis of the presented database indicates insufficient diagnosis of the complications associated with chronic hypoparathyroidism. Overall, hypoparathyroidism is associated with higher risks of renal stone formation, decreased GFR, cataract especially in patients with longer duration of disease.