bluuebunny/crossref_metadata_2025 huggingface dataset:
Regulation of The antibiotic Elution Profile from Tricalcium Phosphate Bone Cement by Addition of Bioactive Glass
Authors: Elwan R. L. , Farag Mohammad M. , Abdelraof Mohamed , El-Hamid H. K. Abd
Published: September 2023

Bioactive glass (BG) synthesized by melt-quenching technology, was added in amounts of 5, 10, 15, and 20 weight percent to β-tri-calcium phosphate cement (β-TCP), which was made via a solid state reaction. The cement and its composites' bioactivity behavior was assessed by soaking them in simulated body fluid (SBF) at 37 ± 0.5°C for 28 d. Measurements were made to determine the physico-mechanical characterizes of cement and its composites. After soaking, the pH and concentrations of Ca, and P ion of the SBF solution were estimated. X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM) combined with energy dispersive spectroscopy (EDS) were used to analyze the structure. Furthermore, by loading gentamicin onto the samples and studying their release profile, the possibility of using them as a drug carrier was explored. A drug release profile that is sustained by all samples was achieved. Addition of bioactive glass to β-TCP decreased drug release rate. Additionally, the antimicrobial property (both bacterial and fungal pathogens) was also assessed. This makes these substances ideal choices for limiting the growth of bacteria once they are implanted in teeth or bone. The results showed that after being submerged in SBF solution, the materials under study develop a layer of hydroxyapatite (HA). It should be highlighted that adding more BG to the current cement composition enhances the material's mechanical and bioactivity characteristics.
An algorithm using edge attribution and bilateral scanning to generate spherical raster Voronoi diagrams
Authors: Song Zhixue , Wang Lei , Zhao Hanxu , Zhang Pengfei , Yin Nan
Published: September 2023

The spherical Voronoi diagram is an important research field in computational geometry, and the method that generates it is a key technology. Most spherical raster algorithms are extensions of planar algorithms. The attribution determination algorithm is one of the most accurate spherical raster Voronoi algorithms. However, it deals inefficiently with large amounts of data. To overcome this issue, a spherical Voronoi diagram generation algorithm that combines edge attribution with bidirectional scanning based on octahedral subdivision is proposed. A coordinate conversion method is built to perform coordinate transformation between latitude–longitude and Cartesian coordinates. The Voronoi attributions of edge grids are determined by computing and comparing the distances to all the sites. A 3×3 template is designed for forward scanning, where grids obtain attributions from their neighbors. Reverse error correction scanning is conducted based on the forward scanning result to guarantee that all grids are correctly assigned. Experiments were conducted to compare the proposed algorithm with the attribution determination algorithm, showing that it has the same accuracy while saving more than 40% of computations. The efficiency advantage of the proposed algorithm becomes more obvious at higher resolutions.
Integrating transcriptomics and metabolomics to analyze the protective effect of taurine on doxorubicin-induced depression
Authors: Li Yanan , Wei Shanshan , Liang Benhui , Chu Xue , Wang Lei , Liu Hui , Liao Dehua , Liu Daotong , Jiang Pei , Yao Jia
Published: September 2023

Objective: Doxorubicin (Dox) is an effective anticancer drug with potent antitumor activity. However, the application of Dox is limited by its adverse reaction, including depression. Taurine can alleviate depression induced by multiple factors. It is still unclear if and how taurine improves DOX-induced depression.
Methods: Mice were randomly divided into three groups (n = 4): (1) the control group, (2) the DOX group, and (3) the DOX+Taurine group. The open field test (OFT), elevated plus maze test (EPM), and forced swim test (FST) were first performed to assess the effects of Dox and taurine on the behavior of mice. Next, a combined transcriptomic and metabolomic analysis was performed to analyze the possible anti-depressive effect of taurine.
Results: Taurine pretreatment increased the total travel time of mice in OFT and the time spent in the open arm in the EMP test and reduced the immobility time in FST. In addition, 201 differential genes and 51 differential metabolites were detected in the DOX+Taurine group compared to the DOX group. Furthermore, differential genes and differential metabolites were detected to be jointly involved in 21 pathways, which may be closely related to the antidepressant effect of taurine.
Conclusions: Taurine alleviated DOX-induced depressive behavior. The various pathways detected in this study such as serotonergic synapse, and the inflammatory mediator regulation of TRP channels may be key regulatory pathways related to depression and antidepressant effects.
Association of SGLT-2 Inhibitors with Thyroid Dysfunction: A Drug-Target Mendelian Randomization Study
Authors: Fu Chao , Liu Dongbo , Liu Qi , Wang Xuedong , Ma Xiaoxue , Yang Mengyue , Qiao Weishen , Pan Hong , Feng Shi , Sun Zhao , Liu Bo , Huang Xingtao , Hou Jingbo
Published: September 2023

Context: Diabetes and thyroid dysfunction are prevalent endocrine disorders. Diabetes substantially increases the incidence of thyroid dysfunction, and the concurrent presence of diabetes and thyroid dysfunction further heightens the risk of adverse events associated with diabetes. However, no studies have been conducted to investigate the impact of novel antidiabetic medications, particularly sodium-glucose co-transporter 2 (SGLT-2) inhibitors, on thyroid dysfunction.
Objective: This study aims to estimate the causal associations of SGLT-2 inhibitors with thyroid dysfunction.
Methods: We extracted single-nucleotide polymorphisms associated with SLC5A2 gene expression and glycated hemoglobin A1c levels from a genome-wide association study predominantly conducted in individuals of European descent. These genetic variants were utilized as tools to simulate the effects of SGLT-2 inhibitors. Subsequently, we conducted drug-targeted mendelian randomization (MR) studies to assess the impact of SGLT-2 inhibitors on thyroid dysfunction and captured the results demonstrating this effect.
Results:The inverse variance-weighted method served as the primary analysis technique in the MR study. Treatment with SGLT-2 inhibitors, predicted through genetic analysis, is strongly linked to a higher risk of thyroid disease (OR: 4.63, 95%CI: 2.94-7.28, p=3.23E-11), especially hypothyroidism (OR: 8.99, 95%CI: 5.31-15.25, p=3.46E-16). Furthermore, SGLT-2 inhibitors treatment substantially raises the occurrence of hyperthyroidism (OR: 1.01, 95%CI: 1-1.03, p=0.02). Conversely, immune dysfunction plays a significant role in the development of both hyperthyroidism and hypothyroidism, and SGLT-2 inhibitors treatment significantly increases the incidence of these related diseases (OR: 3.94, 95%CI: 2.74-5.67, p=1.63E-13).
Conclusions: Our study found that the use of SGLT-2 inhibitors significantly increases the incidence of thyroid dysfunction.
Effect of ultrasound-assisted pretreatment on the hygroscopic dimensional stability of Ailanthus altissima wood modified with 1,3-dimethylol-4,5-dihydroxy ethylene urea
Authors: Han Taoyu , Gao Jingjing , Lu Manman , Avramidis Stavros , Liu Shengquan , He Zhengbin , Qian Jing
Published: September 2023

Fast-growingwood is particularly favored as the lightweight material and has potential used in construction and furniture. However, dimensional instability, one of fast-growing wood’s inherent weaknesses, limits its utilization as solid wood products. In this study, fast-growing Ailanthus altissimawood was modified with 1,3-dimethylol-4,5-dihydroxy ethylene urea (DMDHEU) after ultrasound-assisted pretreatment to improve its hygroscopic dimensional stability. Ultrasound was first used in combination with DMDHEU for wood impregnation modification. The weight percentage gain (WPG), absolute dry density, tangential/radial swelling rates, resin distribution and functional groups of chemical components were investigated. The results indicated that the WPG and absolute dry density of DMDHEU-ultrasonic samples increased compared to DMDHEU-untreated samples. The hygroscopic dimensional stability of DMDHEU-ultrasonic samples improved to varying degrees compared to DMDHEU-untreated samples. In particular, the tangential/radial swelling rates of DMDHEU-ultrasonic-4% NaOH samples decreased from 2.01%/1.22% for untreated samples to 0.55%/0.38%. On the one hand, ultrasound-assisted pretreatment affected the distribution of resin inside vessel. Raised-membranous resin appeared along the vessel of DMDHEU-ultrasonic-4% NaOH samples, while only sporadic resin deposition was observed for the DMDHEU-untreated samples. On the other hand, ultrasound-assisted pretreatment promoted better penetration of the DMDHEU resin into the wood cell wall, and the hydroxyl groups in the hydrophilic part were converted into hydrophobic ester bonds and ether bonds. In conclusion, ultrasound-assisted pretreatment had a positive effect on the wood DMDHEU impregnation. And these findings shed light on promising pretreatment methods for wood dimensional stability modification.
CH4 emission from runoff water of Alaskan mountain glaciers
Authors: Konya Keiko , Sueyoshi Tetsuo , Iwahana Go , Morishita Tomoaki , Uetake Jun , Wakita Masahide
Published: September 2023

Methane (CH4) emissions from runoff water (RW) were observed at the terminus of glaciers in Alaska. The observed CH4 concentration was three times higher than ambient air and a high level of dissolved CH4 in RW was also measured. Although CH4 is relatively well observed as the second most important greenhouse gas, observations in the glacier areas are still rare because the conditions are not considered favorable for CH4 production. However, recent studies have observed CH4-saturated RW and resulting high concentrations of CH4 in the ambient air at the glacier terminuses of the Greenland Ice Sheet and the ice cap in Iceland. This study shows that similar CH4 production also occurs in smaller mountain glaciers. We have selected typical mountain glaciers as the study sites: the Castner, Canwell, and Gulkana Glaciers in the Alaska Range, and the Matanuska Glacier in southern Alaska. Ambient CH4 concentrations at the meltwater outlet, surface CH4 fluxes, and dissolved CH4 content in the RW were measured. The results show that some glaciers have high CH4 concentrations in the RW and in the ambient atmosphere. This is the first case where obvious CH4 emissions have been detected at the terminus of mountain glaciers. This suggests that CH4 release at the terminus of glaciers may be a common occurrence and has the potential to affect the global CH4 budget and climate projections.
Evaluation of the Convection Permitting Regional Climate Model CNRM-AROME on the complex orographic island of Corsica
Authors: Hernández Virginia Edith Cortés , Caillaud Cécile , Bellon Gilles , Brisson Erwan , Alias Antoinette , Lucas-Picher Philippe
Published: September 2023

Meteorological processes over islands with complex orography could be better simulated by Convection Permitting Regional Climate Models (CP-RCMs) thanks to an improved representation of the orography, land-sea contrasts, the combination of coastal and orographic effects, and explicit deep convection. This paper evaluates the ability of the CP-RCM CNRM-AROME (2.5-km horizontal resolution) to simulate relevant meteorological characteristics of the Mediterranean island of Corsica for the 2000-2018 period. These hindcast simulations are compared to their driving Regional Climate Model (RCM) CNRM-ALADIN (12.5-km horizontal resolution and parameterised convection), weather stations for precipitation and wind and gridded precipitation datasets. The main benefits are found in the representation of i) precipitation extremes resulting mainly from mesoscale convective systems affected by steep mountains during autumn and winter months and ii) the formation of convection through thermally induced diurnal circulations and their interaction with the orography during summer. Simulations of hourly precipitation extremes, the diurnal cycle of precipitation, the distribution of precipitation intensities, the duration of precipitation events, and sea breezes are all improved in the 2.5-km simulations with respect to the RCM, confirming an added value. However, existing differences between model simulations and observations are difficult to explain as the main biases are related to the availability and quality of observations, particularly at high elevations. Overall, better results from the 2.5-km resolution, increase our confidence in CP-RCMs to investigate future climate projections for Corsica and islands with complex terrain.
Effect of pore structure of paper-based separators on lithium-ion battery performance
Authors: Wang Yang , Ying Ruifu , Han Gaoyi
Published: September 2023

The two kinds of separators with different pore structure using PET paper as substrate were prepared. The PET ceramic (PC) separator was prepared by filling the macropores of PET paper with ceramic particles. Lyocell fibrillated fiber with a diameter of several hundred nanometers was introduced between PET paper and ceramic particles to produce a PET/Lyocell/ceramic (P/L/C) separator with a three-layer gradient pore structure. Compared with the PE/C microporous separator, the PC and P/L/C paper-based separator both have larger pore size and porosity. However, the P/L/C separator showed better cycle performance than that of PC separator. The large-size blocked areas in PET paper hinder ion transport, and the multilayer gradient pore structure of P/L/C separator can optimize the uniform of ion transport.
Copper complex containing N-acylhydrazone as catalyst in ethanol electro-oxidation reaction
Authors: Silva Daniele Scheles Rosa , Cruz Ruan Santos , Silva Luiza Madeira , Santos Daniela Corrêa , Nagurniak Glaucio R. , Caramori Giovanni F. , Dutra Jocely Lucena , Souza Andrea Luzia Ferreira , Maia Paulo José Sousa
Published: September 2023

This study discusses the synthesis and characterization of a novel copper complex, whose molecular structure was previously determined through various analytical techniques such as FTIR, elemental analysis (CHN), and 1H NMR. Further analysis involving geometry, vibrational frequencies, and electron excitations was conducted using density functional theory (BP86/Def2-TZVPP/D3BJ method). The Cu(MFMH)2Cl2 complex exhibits three absorption bands at 420 nm, associated with π → π* transitions (between ligands); at 477 nm, linked to σ* → π transitions (involving donation from the metallic center to ligands) and π → σ* transitions (involving retro-donation from ligands to the metallic center); and at 514 nm, associated with σ* → π transitions (involving donation from the metallic center to ligands). Additionally, the use of Cu(MFMH)2Cl2 as a catalyst for the ethanol oxidation reaction in acidic conditions was investigated through cyclic voltammetry and chronoamperometry. The results show that the peak-current density for the Cu-CPE 30% (p/p) catalyst (complex/graphite) was higher compared to other CPEs.
Deep learning segmentation of the choroid plexus from structural magnetic resonance imaging (MRI): validation and normative ranges across the adult lifespan
Authors: Eisma Jarrod J. , McKnight Colin D. , Hett Kilian , Elenberger Jason , Song Alexander K. , Considine Ciaran , Claassen Daniel O. , Donahue Manus J.
Published: September 2023

Background: The choroid plexus functions as the blood-cerebrospinal fluid barrier, plays an important role in neurofluid production and circulation, and has gained increased attention in light of the recent elucidation of neurofluid circulation dysfunction in neurodegenerative conditions. However, methods for routinely quantifying choroid plexus volume are suboptimal and require technical improvements and validation. Here, we propose three deep learning models that can segment the choroid plexus from commonly-acquired anatomical MRI data and report performance metrics and changes across the adult lifespan.Methods: Fully convolutional neural networks were trained from 3-D T1-weighted, 3-D T2-weighted, and 2-D T2-weighted FLAIR MRI and gold-standard manual segmentations in healthy and neurodegenerative participants across the lifespan (n=50; age=21-85 years). Dice coefficients, 95% Hausdorff distances, and area-under-curve (AUCs) were calculated for each model and compared to segmentations from FreeSurfer using two-tailed Wilcoxon tests (significance criteria: p<0.05 after false discovery rate multiple comparisons correction). Metrics were regressed against lateral ventricular volume using generalized linear models to assess model performance for varying levels of atrophy. Finally, models were applied to an expanded cohort of healthy adults (n=98; age=21-89 years) to provide an exemplar of choroid plexus volumetry values across the lifespan.Results: Deep learning results yielded Dice coefficient=0.72, Hausdorff distance=1.97 mm, AUC=0.87 for T1-weighted MRI, Dice coefficient=0.72, Hausdorff distance=2.22 mm, AUC=0.87 for T2-weighted MRI, and Dice coefficient=0.74, Hausdorff distance=1.69 mm, AUC=0.87 for T2-weighted FLAIR MRI; values did not differ significantly between MRI sequences and were statistically improved compared to current commercially-available algorithms (p<0.001). The intraclass coefficients were 0.95, 0.95, and 0.96 between T1-weightedand T2-FLAIR, T1-weighted and T2-weighted, and T2-weighted and T2-FLAIR models, respectively. Mean lateral ventricle choroid plexus volume across all participants was 3.20±1.4 cm3; a significant, positive relationship (R2=0.54; slope=0.047) was observed between participant age and choroid plexus volume for all MRI sequences (p<0.001).Conclusions: Findings support comparable performance in choroid plexus delineation between standard, clinically available, non-contrasted anatomical MRI sequences. The software embedding the evaluated models is freely available online and should provide a useful tool for the growing number of studies that desire to quantitatively evaluate choroid plexus structure and function (https://github.com/hettk/chp_seg).
X-ray Dark-field Computed Tomography for Monitoring of Cryoablation Procedures: A Phantom Study
Authors: John Dominik , Gottwald Wolfgang , Berthe Daniel , Wirtensohn Sami , Hickler Julia , Heck Lisa , Herzen Julia
Published: September 2023

Cryoablation is a minimally invasive treatment option for malignancies in which cell death is induced by freezing tissue with a cryoprobe. However, the extent of the frozen region must be monitored to avoid unnecessary damage to surrounding healthy tissue and to ensure encapsulation of the tumor. One commonly used monitoring method, attenuation-based computed tomography (CT), allows visualization of the ice ball using its hypoattenuating properties compared to unfrozen tissue. However, the contrast between frozen and unfrozen tissue remains low. We show that using a Talbot-Lau interferometer, this contrast can be greatly enhanced by acquiring dark-field images that capture the increasing small-angle scattering caused by the ice crystals formed during the procedure. Our results show that, compared to attenuation, the frozen region is detected significantly better in dark-field radiographs and CT scans of a porcine phantom mimicking breast tissue. This suggests a potential improvement in the accuracy of cryoablation therapy through the use of dark-field imaging, potentially leading to better patient outcomes.
RETRACTED: Prostaglandin E2-EP4 signaling suppresses bioenergetics and ribosome biogenesis in immune cells infiltrating human tumor
Authors: Narumiya Shuh , Punyawattananukool Siwakorn , Wongchang Thamrong , Katsurada Nao , Matsuura Ryuma , Kawashima Masahiro , Toi Masakazu , Yamanoi Koji , Hamanishi Jyunzo , Hisamori Shigeo , Obama Kazutaka , Charoensawan Varodom , Thumkeo Dean
Published: September 2023

The authors have requested that this preprint be removed from Research Square.
THE EFFECT OF CASH RATIO AND RETURN ON ASSET ON FIRM VALUE OF CONSTRUCTION COMPANIES SUB SECTOR LISTED ON THE IDX FOR THE 2019-2022 PERIOD
Authors: Al-Kautsar Haikal Farrel , Ardhani Alif Mulya , Maula Kholda Atiyatul , Hakim Heikal Muhammad Zakaria
Published: September 2023

The rise of default problems due to poor asset management has an impact on decreasing investor confidence, which affects the value of a company. “This observation aims to examine how the correlation between Cash Ratio and Return on Assets on Company Value is proxied by Price to Book Value, both partially and simultaneously in building construction sub-sector companies with a focus on research for the period 2019 to 2022. This observation makes use of Multiple linear regression as a research method uses SPSS 25 with reference to the classical assumption feasibility test as well as the T-test and F-test. The results of this study show that partially, the cash ratio has a negative but not significant effect on firm value, while return on assets has a positive and significant effect on firm value. Simultaneously, the cash ratio and return on assets together have a positive and significant influence on firm value with a determinant contribution (R Adjusted Square) of 20.5% in explaining the escalation of firm value variables.
Boundary chaos: Exact entanglement dynamics
Authors: Fritzsch Felix , Ghosh Roopayan , Prosen Tomaž
Published: September 2023

We compute the dynamics of entanglement in the minimal setup producing ergodic and mixing quantum many-body dynamics, which we previously dubbed boundary chaos. This consists of a free, non-interacting brickwork quantum circuit, in which chaos and ergodicity is induced by an impurity interaction, i.e., an entangling two-qudit gate, placed at the system’s boundary. We compute both the conventional bipartite entanglement entropy with respect to a connected subsystem including the impurity interaction for initial product states as well as the so-called operator entanglement entropy of initial local operators. Thereby we provide exact results in a particular scaling limit of both time and system size going to infinity for either very small or very large subsystems. We show that different classes of impurity interactions lead to very distinct entanglement dynamics. For impurity gates preserving a local product state forming the bulk of the initial state, entanglement entropies of states show persistent spikes with period set by the system size and suppressed entanglement in between, contrary to the expected linear growth in ergodic systems. We observe similar dynamics of operator entanglement for generic impurities. In contrast, for T-dual impurities, which remain unitary under partial transposition, we find entanglement entropies of both states and operators to grow linearly in time with the maximum possible speed allowed by the geometry of the system. The intensive nature of interactions in all cases causes entanglement to grow on extensive time scales proportional to system size.
The influence of tropical pasture improvement on animal performance, nitrogen cycling, and greenhouse gas emissions in the Brazilian Atlantic Forest
Authors: Alecrim Fabiano Barbosa , Alves Bruno José Rodrigues , Rezende Claudia de Paula , Boddey Robert Michael , Nóbrega Gabriel Nuto , Cesário Fernando Vieira , Leite Fernanda Figueiredo Granja Dorilêo , Pereira Carlos Rodrigues , Rodrigues Renato de Aragão Ribeiro
Published: September 2023

This study evaluated beef cattle performance, nitrogen (N) dynamics, and potential greenhouse gas emissions (GHG) in tropical pastures receiving N fertilization or mixed with legumes. During the cool season, 54 Nellore heifers were randomly allotted to continuous grazing in three plots of each pasture type: T1 (Marandu grass with 150 kg N/ha), T2 (Marandu grass with 120 kg N/ha), T3 (Marandu grass with Arachis pintoi), T4 (Marandu grass with Desmodium heterocarpo), T5 (Marandu grass without N fertilization), and T6 (degraded pasture). The stocking rate was periodically adjusted to achieve the target canopy height of 20–25 cm. Animal performance and N livestock excretion were estimated by variation in live weight and spot samples of urine and feces, respectively. GHG emissions were calculated using the methodology of the Intergovernmental Panel on Climate Change. Animal performance was higher in fertilized and mixed pastures (e.g., T1 to T4) than in T5 and T6 pastures. Heifers grazing on T1, T2, T3, and T4 excreted lower amounts of urine with higher N concentrations than heifers grazing on T5 and T6. Heifers grazing in T2 and T4 pastures had a lower concentration of fecal N than those grazing on other pastures, reflecting lower N excretion in this form. The potential for direct nitrous oxide emissions per unit area in pastures mixed with legumes was approximately four times lower than that in pastures with mineral N fertilization. The recovery of degraded pastures and the inclusion of forage legumes contributed to maintaining the sustainability of animal production in pastures
Characterization and Biological Activity of Native and Sulfated Noni (Morinda citrifolia Linn.) Pectin
Authors: Santos Denilton , Cunha Arcelina , Ribeiro Ana , Brito Débora , Alenca Luciana , Farias Davi , Carvalho Ana , Sousa João , Leal Luzia , Lopes Nayara , Linhares Rosa , Nozawa Carlos , Uchoa Antonia , Ribeiro Maria , Ricardo Nágila
Published: September 2023

The aim of this work was to extract and characterize pectin from lyophilized noni pulp (Morinda citrifolia Linn.) at three different pHs using different extractor agents and to evaluate anti-viral activity. The extraction of high yield (acid extraction) was subjected to sulfation procedure. Fourier transform infrared spectroscopy and proton nuclear magneticresonance analysis were used to calculate the degree of methylation of pectin from acid extraction and its sulfated derivative. The data obtained for the degree of methylation of noni pectin and sulfated pectin were 30.3 and 30.7, respectively. Pectin was subjected to acute oral toxicity testing in mice. The results showed that pectin had a pro-inflammatory effect, and sulfated pectin had an anti-inflammatory effect. Both pectins were also evaluated for herpes simplex virus activity in vitro, and although they successfully inhibited virus replication, the sulfated pectins were cytotoxic.
Associations between seasonality and faecal contamination of self-supply sources in urban Indonesia
Authors: Genter Franziska , Putri Gita Lestari , Maysarah Siti , Rolia Eva , Pratama Mochamad Adhiraga , Priadi Cindy , Willetts Juliet , Foster Tim
Published: September 2023

Water quality monitoring that accounts for seasonal variability is crucial to ensure safe water services at all times, including groundwater self-supply, which provides drinking water for more than 40 million people in urban Indonesia. Seasonal variation of self-supply water quality remains a key evidence gap in Indonesia and elsewhere; therefore, this study investigated the associations between seasonality and faecal contamination of groundwater self-supply in the Indonesian cities of Bekasi and Metro. The study demonstrated mixed results in terms of associations between seasonality and microbial water quality. McNemar's test showed that high concentrations of Escherichia coli (E. coli) (≥100 MPN per 100 mL) were significantly more likely during the wet season than during the dry season in Bekasi (p = 0.050), but not in Metro (p = 0.694). There was no statistically significant association between the season and the presence of E. coli in self-supply sources for both study sites, nor was there a significant association between the season and the presence of high concentrations of E. coli at the point-of-use. At both study sites, presence and high concentrations of E. coli during the dry season significantly increased the risk of contamination in the wet season, but the predictive power was weak. Regular water quality testing complemented by sanitary inspection is required to understand the contamination risks of self-supply sources.
Carbon footprint values as a climate change assessment criterion of the partial harvests of European seabass and meagre in earthen pond aquaculture
Authors: Diken Gürkan , Bahrioğlu Ergi
Published: September 2023

Turkey's Mediterranean aquaculture industry is the world leader in European seabass aquaculture and the European leader in meagre aquaculture. In this study, carbon footprint (CF) values of four partial harvests of European seabass in earthen pond aquaculture (EPES) and meagre in earthen pond aquaculture (EPM) were determined. The average values of total CF expended for EPES and EPM, which reached a final harvest weight of approximately 1,500 g in 1,061 and 633 days were 3.38 and 2.26 kg CO2e kg−1, respectively. The lowest and highest rates of CF expended on consumed compound diet (CFCD) were 63.92 and 65.59% in EPES, and 62.44 and 66.70% in EPM, respectively. The rates of CF general management were 32.0 and 33.57% in EPES and 30.98 and 34.98% in EPM, respectively. Against this high proportion of the compound diet, the second highest value was the lowest and highest proportion of partial harvests of electricity, 28.20 and 29.59% in EPES and 27.09 and 30.51% in EPM, respectively. CF input and CF output per kg values of meagre were decreased with increasing weight, therefore meagre can be defined as a species with high global food security and resilience against climate change.
Evaluation of syphilis co-infection and monitoring of rapid plasma reagin (RRP) titer according to syphilis-stage in human immunodeficiency virus-infected patients
Authors: ARICI Neslihan , ANKARALI Handan , KANSAK Nilgün , ADALETİ Rıza , AKSARAY Sebahat
Published: September 2023

Aim: Syphilis co-infection in HIV-infected patients is associated by a delayed serological response. The aim of this study is to obtain current data on the frequency of HIV/syphilis co-infection, the monitoring of rapid plasma reagin (RPR) titer after treatment, and factors affecting the serologic response.

Methods: Serological tests for syphilis of HIV patients followed between January 2015 and March 2023 were evaluated retrospectively. Demografic data (age, sex), level of HIV RNA, RPR, Treponema pallidum haemagglutination test (TPHA), and syphilis stage were obtained from hospital electronic database. Serological response was defined according to Centers for Disease Control and Prevention (CDC) criteria.

Results: Syphilis co-infection was detected in 36.2% of the patients, all of them were male. Distribution of syphilis stage was primary 2.9%, secondary 9.7%, latent 80.6%, and neurosyphilis 6.8%, respectively. All patients with primary, secondary, and neurosyphilis had ≥4-fold decrease in RPR titer within 12 months after treatment, while two patients with latent syphilis didn’t have a decrease in titer within 12-24 months. Overall serologic response was 95.8%. Comparing the time to a 4-fold decrease in the RPR titer in terms of syphilis stage, there was no statistically significant difference. Patients with initial RPR titer >1: 32 achieved faster serologic response than those with initial RPR titer ≤1: 32.

Conclusion: HIV/syphilis coinfection rate was notably high. It is promising that most patients had a serologic response within the time-frame defined by the CDC. It should be considered that treatment response may take longer in patients with an initial RPR titer ≤32. Further prospective studies are needed to understand the factors associated with serologic response in HIV/syphilis co-infected patients.
The relationship between physical activity and pain, interoceptive awareness, and personal well-being in women with fibromyalgia: A cross-sectional study
Authors: PASİN Tuğçe , DOGRUOZ KARATEKİN Bilinc
Published: September 2023

Aim: In this study, the effect of physical activity level on pain, interoceptive awareness, and personal well-being in women with fibromyalgia was investigated.

Methods: Fifty female patients diagnosed with fibromyalgia syndrome who applied to the physical medicine and rehabilitation outpatient clinic were evaluated as follows: Demographics (age, occupational status, and body mass index (BMI)) were recorded, pain levels were evaluated with visual analog scale (VAS), physical activity levels were evaluated with the international physical activity questionnaire (IPAQ), personal well-being were evaluated with the personal well-being index adult form (PWI-A) and interoceptive awareness were evaluated with multidimensional assessment of interoceptive awareness (MAIA).

Results: The mean age of the participants was 50.96±8.35, and the mean BMI was 27.74±4.01. Fifty-four % of the participants had low physical activity levels and 46% had moderate physical activity levels. The mean MAIA total score was 19.44±3.73 and the mean VAS was 6.32±1.69. In correlation analysis, a large negative statistically significant relationship between VAS and PWI-A (p
COVID-19 e transformação digital de uma empresa júnior de Psicologia
Authors: Do Carmo Gabriela Perle , Zarife Pricila de Sousa
Published: September 2023

A pandemia de COVID-19 acelerou a transformação digital nas organizações, ao suscitar o uso da tecnologia para sobrevivência e criação de novos modelos de negócios mais digitais e contemporâneos. Sendo as empresas juniores (EJs) reconhecidas como a melhor estratégia de aprendizagem prática, constituindo um espaço fomentador do desenvolvimento de competências importantes para o mercado de trabalho, bem como a incipiência da literatura sobre as EJs é importante  investigar como a transformação digital vem ocorrendo nas EJs , especialmente durante a pandemia. Este trabalho buscou analisar a experiência de transformação digital de uma empresa júnior brasileira de Psicologia durante a pandemia de COVID-19. Trata-se de um relato de experiência, realizado com observações e reuniões remotas com membros da EJ. No período pré-pandemia, a EJ estava na transição entre os níveis 0 (não digital) e 1 (presente) do Modelo de Maturidade Digital de Negócios, tendo evoluído para o nível 2 (engajamento eletrônico) durante a pandemia. Tal progresso se deu pelas ações empreendidas para adaptação ao trabalho remoto imposto pelo isolamento social. O processo de transformação digital da EJ seguiu as cinco etapas propostas no modelo HINGE. Almeja-se que este trabalho auxilie outras EJs no processo de transformação digital, bem como incentive o desenvolvimento de pesquisas sobre as EJs.
lado mais sombrio da motivação:
Authors: Pedersini Daiana Rafaela , Meurer Alison Martins , Antonelli Ricardo Adriano
Published: September 2023

O estudo objetiva analisar a associação da desmotivação acadêmica com as estratégias utilizadas pelos professores para promover o aprendizado a partir da percepção de estudantes do curso de Ciências Contábeis. A amostra da pesquisa consistiu em 200 estudantes do curso de Ciências Contábeis de duas instituições de ensino superior da região sul do país. Os resultados obtidos a partir de estatística descritiva e da Correlação de Spearman indicaram que a valorização do esforço do aluno, a inserção tecnológica e as visitas de campo estão entre as estratégias preferidas dos estudantes. Em termos associativos, os resultados insinuam que alunos que se desmotivam pela dificuldade de aprender o conteúdo do curso têm sua percepção positivamente associada a importância dos professores em reconhecer as emoções negativas dos alunos, valorizar mais o esforço do aluno do que o resultado obtido por ele e evitar a comparação do desempenho entre os alunos.
Até que ponto eu aguento! Vivências de prazer e sofrimento de terceirizados em uma instituição federal de ensino superior
Authors: Silva Laíse do Nascimento , Barroso Elane dos Santos Silva , Oliveira Júnior Marcos Antonio Cavalcante de , Teixeira Linnik Israel Lima
Published: September 2023

O trabalho representa o elemento essencial na construção social do indivíduo, podendo ser fonte de prazer e sofrimento. Define-se a terceirização como o repasse de atividades de uma organização para terceiros. O estudo consistiu em analisar as vivências de prazer e sofrimento de terceirizados que atuam nos serviços de limpeza em uma instituição federal pública à luz da Psicodinâmica do Trabalho. Utilizou-se uma metodologia de abordagem qualitativa, cunho descritivo, empregando a análise de conteúdo de Bardin (2011). Teve-se a pesquisa de campo enquanto procedimento técnico e a aplicação de um roteiro de entrevista adaptado do instrumento ITRA – “Inventário sobre Trabalho e Riscos de Adoecimento”, de Mendes e Ferreira (2007), para a coleta e análise dos dados. Evidenciou-se que o trabalho é visto como prazeroso, os recursos suficientes e o relacionamento tranquilo, apesar das limitações como falta de tempo para ir ao médico, divisão das tarefas, problemas físicos e cognitivos. Os terceirizados realizam suas atividades conforme as diretrizes impostas pela organização e evitam conflitos, tendo o controle emocional como estratégia de defesa. Identifica-se a presença de invisibilidade, uma vez que evitam manifestar seus sentimentos e suas necessidades de alternativas que minimizem os riscos de adoecimento
Diseño y validación de un cuestionario para el desarrollo de la capacidad innovadora en medianas y grandes empresas
Authors: Rubio-Rodríguez Gustavo Adolfo , Méndez Ortiz Yeison Farid , Rubio Guerrero Germán , Palma Cardoso Elizabeth
Published: September 2023

Con la finalidad de contar con un cuestionario sólido para la generación y el desarrollo de la capacidad de innovación de medianas y grandes empresas de la ciudad de Ibagué, Colombia, el presente artículo presenta el proceso de diseño, fiabilidad y validez de este instrumento de recolección de datos, mediante un estudio cuantitativo que comprendió, entre otros aspectos, el análisis factorial y los estadísticos de confiabilidad y validez; considerando una muestra piloto de 15 empresas seleccionadas aleatoriamente, de las cuales, a través de un muestreo estratificado, se seleccionaron 3 empresas grandes y 12 empresas medianas. Esto, sobre un muestreo de 130 organizaciones de una población total de 196. El resultado final lo constituye el diseño y validación estadística del cuestionario con 4 dimensiones y 30 reactivos con un alfa de Cronbach de 0,90, que a la postre se constituyó en el instrumento de recolección de la información.
O protagonismo da professora Zuleide Fernandes Queiroz
Authors: Fialho Lia Machado Fiuza , Costa Freire Vitória Chérida , Andrade de Sousa Francisca Genifer
Published: September 2023

O artigo trata do dinamismo militante de uma mulher negra que conseguiu deslocamento social e destacou-se por sua luta pela interiorização da pós-graduação, maior justiça social e igualdade de gênero e raça. O objetivo foi biografar Zuleide Fernandes Queiroz com ênfase na sua atuação como docente universitária militante política e sua inserção nos movimentos negro, sindical e feminista, no recorte temporal de 1994 a 2019. Desenvolveu-se uma pesquisa do tipo biográfica, ancorada teoricamente na História Cultural e metodologicamente na História Oral. Os dados foram coletados por intermédio de entrevista livre com a biografada. Os resultados inferem que a atuação docente de Zuleide Fernandes Queiroz na Universidade Regional do Cariri fomentou, por meio do ensino e da pesquisa, um projeto de educação libertadora que considera os problemas práticos da realidade social do Nordeste, os quais dificultam a emancipação humana, em especial da mulher. Protagonista na expansão da oferta de curso de graduação e na implementação da pós-graduação em Educação no interior do Ceará, desenvolveu sua práxis educativa indissociada da sua militância política, pois a sua luta mostrou-se diária em prol da resistência às discriminações e às desigualdades agravadas pelo preconceito de raça, de classe e de gênero.
Na universidade brasileira, maternidade rima com produtividade científica?
Authors: Protetti Fernando Henrique , Souza Aparecida Neri de
Published: September 2023

Nesse artigo, analisamos as relações entre carreira acadêmica e maternidade, a partir de pesquisa empírica com depoimentos coletados com quatro professoras de sociologia da Universidade Estadual de Campinas (Unicamp). Nesses depoimentos, interrogamos: quais são as tensões entre carreira e maternidade experienciadas por essas professoras? Como as professoras mães e as professoras sem filhos articulam maternidade e carreira? Em suma, na universidade brasileira maternidade rima com a produtividade científica? O trabalho de Bitencourt (2013) sobre maternidade e carreira de acadêmicas na fase de doutorado, além de pioneiro, permitiu-nos um diálogo teórico-metodológico para a análise das relações entre carreira e maternidade. Os resultados obtidos informam que as professoras mães experienciam múltiplas tensões nas relações entre carreira acadêmica e maternidade: jornadas de trabalho extenuantes, delegação do trabalho reprodutivo a outrem, maior tempo para a construção da carreira e sentimento de culpa frente à dificuldade de conciliação da maternidade com a carreira. Para as professoras sem filhos, a escolha pela não maternidade em defesa da carreira, fundamentada na produtividade científica, constitui-se na principal tensão experienciada. Se a produtividade científica é o motor da carreira acadêmica atual, a maternidade tende a figurar como um empecilho para a construção da carreira acadêmica.
(Des)igualdade de gênero na carreira acadêmica
Authors: Dellazzana-Zanon Letícia Lovato , Dellazzana Ângela Lovato , Sousa Marcela Pereira de , Souza Lidiane dos Santos
Published: September 2023

A maternidade acadêmica refere-se aos desafios enfrentados por mulheres que se tornam mães durante o período em que estão galgando a carreira acadêmica. Este estudo teve como objetivo sistematizar informações sobre maternidade acadêmica em diferentes etapas da carreira considerando o contexto pandêmico. Por meio de uma revisão narrativa, foram sistematizados resultados de pesquisas realizadas no período de 2016 a 2021, em diferentes países, organizadas em cinco temáticas: estereótipos de gênero na carreira acadêmica, escolhas maternas na carreira acadêmica, impactos da gestação e da maternidade na academia, maternidade acadêmica no contexto pandêmico e redes de apoio. Os resultados indicaram que há uma predominância de estudos internacionais sobre a temática. Neste contexto, as políticas públicas implementadas para as pesquisadoras mães não foram suficientes para ampará-las. Elas foram assoladas pela cobrança em relação à produtividade, à dedicação à academia e às tarefas de cuidado dos filhos, principalmente, quando bebês. A ausência total de rede de apoio imposta pela pandemia da Covid-19 trouxe à tona os desafios a que são submetidas as pesquisadoras que se tornam mães, o que, por sua vez, indica a urgência da implementação de políticas públicas que apoiem essas pesquisadoras.
Mulheres economistas
Authors: Guedes Santiago Rosa Cibele , Dos Santos Cristiane Márcia
Published: September 2023

Este estudo tem o objetivo de analisar como as relações de gênero podem influenciar a carreira acadêmica superior de professoras do curso de Economia que lecionam em nove instituições de Minas Gerais: Universidade Federal de Juiz de Fora, Universidade Federal de Minas Gerais, Universidade Federal de Ouro Preto, Universidade Federal de São João del-Rei, Universidade Federal de Uberlândia, Universidade Federal de Viçosa, Universidade Federal de Viçosa (Departamento de Economia Rural), Universidade Federal de Alfenas e Universidade Estadual de Montes Claros. Para tanto, entrevistas estruturadas foram usadas como recurso metodológico com intuito de investigar desde a escolha do curso até o desenvolver da jornada acadêmica dessas mulheres. Assim como em muitas outras profissões, as docentes de Economia enfrentam percalços e renúncias que só podem ser compreendidos na perspectiva de gênero. Dessa forma, os resultados revelaram a existência de barreiras de gênero caracterizadas pela imagem masculina do economista e pela pouca credibilidade dada as mulheres no campo. Além disso, os relatos mostraram que, muitas vezes, para permanecer na carreira docente em Economia é preciso enfrentar preconceitos, discriminações, estereótipos de gênero e sexismo.
Produtividade acadêmica stricto sensu no Nordeste do Brasil sob o recorte de gênero
Authors: Gonçalves Caçula Suzete , Cruz Neto João , De Oliveira Silva Mauro Mccarthy , De Castro Magalhães Beatriz , Alencar Albuquerque Grayce
Published: September 2023

Objetivou-se verificar a produtividade de docentes inseridos/as em programas de pós-graduação stricto sensu, da região Nordeste do Brasil, sob o recorte de gênero. Trata-se de uma pesquisa descritiva, exploratória, de abordagem quantitativa, com coleta de dados realizada nos meses de março a outubro de 2020, via acesso à Plataforma Lattes de 31 docentes do sexo feminino que gozaram licença maternidade, 264 docentes do sexo feminino sem licença maternidade e 339 docentes do sexo masculino, inseridos/as em programas stricto sensu no quadriênio 2017 a 2020. Pode-se observar que as docentes mulheres sem licença maternidade e aquelas com licença maternidade possuem uma média de produtividade acadêmica maior que docentes do sexo masculino, com 63,95, 58,64 e 51,90 respectivamente. Todavia, mesmo com menor produção, verifica-se que docentes homens lideram em quase todas as áreas do conhecimento, com destaque para Engenharias (84,61%). Quando se comparam as docentes que usufruíram de licença maternidade com as que não usufruíram, observa-se redução significativa da produtividade daquelas que gozaram deste direito. Conclui-se que ainda há desigualdade de gênero no ambiente acadêmico/científico e que a maternidade traz consigo impactos na carreira da mulher docente, propiciando declínio de produtividade após o nascimento da criança.
DOCK4 is a Novel Prognostic Biomarker and Correlated with Immune
Infiltrates in Colon Adenocarcinoma
Authors: Xie Xingjiang , Lu Yi , Wang Bo , Yin Xiaobin , Chen Jianfeng
Published: September 2023

Background:

Dedicator for cytokinesis 4 (DOCK4) is a guanine nucleotide exchange
factor (GEF) for the small GTPase Rac1. However, the functions of DOCK4 concerning the tumor
microenvironment (TME) in colon adenocarcinoma (COAD) remain uncertain.

Methods:

The TIMER and GEPIA databases were used to analyze the DOCK4 expression between
COAD tissues and adjunct normal tissues. The PrognoScan database was used to assess the prognosis
of DOCK4 expression in COAD. The co-expression networks of DOCK4 in COAD were
constructed by the LinkedOmics website. Furthermore, the correlation between DOCK4 expression
and TME of COAD was explored using TIMER and TISIDB databases. Finally, the clone formation
assay was used to further verify the function of DOCK4 in COAD. The Western blotting
assay was used to confirm the mechanism related to DOCK4 in COAD.

Results:

The DOCK4 expression was different significantly in COAD tissues and paracancerous
tissues. The DOCK4 was found to play a poor role in the prognosis of patients with COAD. The
DOCK4 was found to participate in the TME by promoting immune evasion of COAD. The reduction
of DOCK4 expression inhibited the clone formation and Ras-associated protein 1A (Rap1A)
expression of HCT116 cells.

Conclusions:

DOCK4 potentially plays an important role in the regulation of TME in COAD.
DOCK4 facilitates the development through the Rap1A pathway, thus becoming a novel prognostic
biomarker in COAD.