bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of paravertebral block on perioperative neurocognitive disorder: a systematic review and meta-analysis of randomized controlled trials
Authors: Wang Lu , Wang Fei , Kang Wanli , Gao Guangkuo , Liu Tao , Chen Bin , Liu Wei
Published: October 2023

Objective

To investigate whether paravertebral block reduces postoperative delirium (POD)/delayed neurocognitive recovery (DNR) in adults after major surgery with general anesthesia.

Methods

For this systematic review and meta-analysis, we searched online databases PubMed, EMBASE, CENTRAL, and Web of Science till March 19th, 2023 to examine studies which use paravertebral block (PVB) for perioperative neurocognitive disorder. Primary and secondary outcomes were identified for the incidence of perioperative neurocognitive disorder. We did not restrict the follow-up duration of the included studies. Statistical analysis was performed to calculate mean difference (MD), Odd ratios (OR) and CI between RCTs. The quality of the evidence was assessed with the Cochrane risk of bias tool. The registration number of the study in PROSPERO is CRD42023409502. PROSPERO is an international database of prospectively registered systematic reviews. Registration provides transparency in the review process and it helps counter publication bias.

Results

Total 1,225 patients from 9 RCTs were analyzed. The incidence of POD [Odds Ratio (OR) = 0.48, 95% CI 0.32, 0.72; p = 0.0004; I2 = 0%] and DNR [OR = 0.32, 95% CI 0.13, 0.80; p = 0.01; I2 = 0%] were significantly reduced in PVB group. The analysis showed no significant differences in postoperative MMSE scores [MD = 0.50, 95% CI −2.14, 3.15; p = 0.71; I2 = 98%]. Paravertebral block analgesia reduces pain scores and/or opioid use after surgery. Additionally, blood pressure was significantly lower in the PVB group, intraoperatively [MD = −15.50, 95% CI −20.71, −10.28; p < 0.001; I2 = 12%] and postoperatively [MD = −5.34, 95% CI −10.65, −0.03 p = 0.05; I2 = 36%]. Finally, PVB group had significantly shorter hospital stays [MD = −0.86, 95% CI −1.13, −0.59; p < 0.001; I2 = 0%].

Conclusion

Paravertebral block analgesia may prevent perioperative POD/DNR in patients undergoing major surgery. Further research with large sample sizes is required to confirm its effectiveness.
Peripheral vestibular loss in noise-exposed firefighters
Authors: Snapp Hillary Anne , Vanlooy Lindsey , Kuzbyt Brianna , Kolberg Courtney , Laffitte-Lopez Denise , Rajguru Suhrud
Published: October 2023

Introduction

Occupational workers are increasingly aware of the risk of noise overexposure to the auditory system but lack awareness about potential risks to the vestibular system. The purpose of this study was to investigate changes in vestibular end organ function in a known at-risk noise-exposed population, firefighters compared to age- and sex-matched controls using electrophysiologic measures of cervical vestibular evoked myogenic potentials (cVEMP).

Methods

A cross-sectional observational study compared cVEMP response characteristics in 38 noise-exposed firefighters. Firefighters were grouped by years of exposure in the fire service. The cVEMP responses were compared within firefighter groups and between firefighters and age- and sex-matched controls. Dependent variables included the response characteristics of amplitude, latency and threshold.

Results

cVEMP response amplitudes were significantly decreased in firefighters compared to their age- and sex-matched controls. Threshold of the cVEMP responses were significantly higher in firefighters compared to controls and firefighters had a higher incidence of absent cVEMP responses compared to controls. Response amplitudes decreased with increasing years in the fire-service at an increased rate compared to their age- and sex-matched controls. Latency of the cVEMP response was not significantly different in firefighters compared to controls. These findings are consistent with both animal and human studies suggesting noise-induced changes in the sacculocollic pathway.

Discussion

In the absence of any reported vestibular symptoms or auditory indicators of noise-induced hearing loss, these early effects on the vestibular system point to a potential hidden vestibular loss.
Case Report: Resolution of high grade anal squamous intraepithelial lesion with antibiotics proposes a new role for syphilitic infection in potentiation of HPV-associated ASCC
Authors: Ranabhotu A. , Habibian N. , Patel B. , Farrell E. , Do J. , Sedghi S. , Sedghi L.
Published: October 2023

Introduction

Human Papillomavirus (HPV) is the primary risk factor for the development of anal intraepithelial neoplasia (AIN) and is a leading risk factor for anogenital squamous cell carcinoma (ASCC). Despite common shared risk factors for both HPV and syphilis, co-infection is not well documented, and the role of syphilitic infection in HPV-associated AIN and ASCC potentiation is not defined.

Case description/methods

A 72-year-old single male presented with complaints of mild rectal pain and intermittent rectal bleeding. A flexible sigmoidoscopy was performed, and a firm 4.5cm x 3cm perianal mass was detected and superficially biopsied. Pathology findings demonstrated evidence of a high grade squamous intraepithelial lesion (HGSIL, AIN II/III/AIS) with viral cytopathic effect, consistent with HPV infection. Much of the biopsied lesion showed acanthotic squamous mucosa with intraepithelial neutrophils and abundant submucosal plasma cells, suggesting possible syphilitic involvement. Subsequent immunohistochemical staining for p16 as a surrogate marker for HPV was positive, as was an immunohistochemical stain for spirochetes, supportive of co-infection with Treponema pallidum pallidum (T. pallidum), the causative agent in venereal syphilis. The patient was referred to an infectious disease specialist for syphilitic infection and was treated with penicillin with surprisingly complete resolution of the lesion. EUAs were performed 2- and 3-months following treatment without lesion recurrence. However, one year following diagnosis, a flexible sigmoidoscopy revealed a 5 mm recurrent HPV-related low-grade AIN 1 lesion at the dentate line.

Discussion

Resolution of the lesion by antibiotic treatment for syphilitic infection suggested that co-infection by T. pallidum may potentiate HPV-associated squamous cell carcinoma based on histological findings. Findings from this case, as well as a review of bacterial involvement and potentiation in various cancers, are reviewed here. Such findings offer new insight regarding the role of STI-associated bacteria and HPV co-infection in the establishment of AIN and may additionally propose new treatment modalities for ASCC.
Vulvar squamous intraepithelial neoplasia epithelial thickness in hairy and non-hairy sites: a single center experience from China
Authors: Xiao Jingjing , Chen Ziren , Xiao Yinping , Sui Long , Wang Chao , Cong Qing
Published: October 2023

Introduction

A large-sample study focusing on VIN lesions of a more precise thickness is needed to help guide clinical treatment. This study aimed to investigate the depth of vulvar intraepithelial neoplasia (VIN) and involved skin appendages to provide evidence for laser surgery.

Methods

The study retrospectively enrolled and analyzed the clinical characteristics of VIN patients in the obstetrics and gynecology department of a university hospital between January 1, 2019 and December 30, 2021. The study further explored the thickness of epithelium and skin appendages of 285 women with low-grade VIN (VIN1) and 285 women with high-grade VIN (VIN2/3).

Results

The study included 1,139 (80%) VIN1 and 335 (20%) VIN2/3 cases. The VIN1 and VIN2/3 groups showed a significant difference in human papillomavirus infection (P<0.01) but not in cytology (P = 0.499). Most (89.90%, 1,325) cases occurred in one area of the vulva, whereas 10.11% were multifocal. VIN commonly occurred on the posterior fourchette (76.85%), labia majora (11.61%), and labia minora (9.92%). The VIN2/3 group reported a significantly higher positive rate for concurrent cervical and vaginal intraepithelial neoplasia (160 of 285) than the VIN1 group (321 of 953) (P=0.000). The involved epithelial thicknesses in VIN2/3 and VIN1 were 0.69 ± 0.44 and 0.49 ± 0.23 mm, respectively, both of which were greater than the corresponding noninvolved epithelial thickness (0.31 ± 0.19 and 0.32 ± 0.10 mm, P<0.001 and P<0.001, respectively). In cases of appendage involvement, the VIN thickness was 1.98 ± 0.64 mm.

Conclusions

VIN thickness was generally ≤1 mm for the superficial lesions in non-hairy areas. However, for lesions extending onto hairy areas, the thickness was approximately 3 mm, leading to the destruction of involved skin appendages.
Similarities and differences in gene expression profiles of BRCA1 methylated and mutated epithelial ovarian cancers
Authors: Sahnane Nora , Libera Laura , Facchi Sofia , Carnevali Ileana , Ronchi Susanna , Albeni Chiara , Cromi Antonella , Casarin Jvan , Sessa Fausto , Tibiletti Maria Grazia
Published: October 2023

Introduction

BRCA1 methylated (BRCA1met) epithelial ovarian cancer (EOC) is a recently defined and not well-investigated subset of neoplasms. To date, no studies have focused on the transcriptional profiles of BRCA1met cases, and, as a matter of fact, we still do not know if this subset of EOCs is similar, and to what extent, to BRCA1 mutated (BRCA1mut) cases.

Methods

We compared a group of 17 BRCA1met cases against 10 BRCA1mut cases using a subset of carefully selected 17 BRCAwt EOCs as a control group.

Results

First, BRCA1met cases showed a downregulation of the relative transcript, while this association was not observed for BRCA1mut EOCs. The BRCA1met group exhibited a general upregulation of homologous recombination (HR)-related genes, as well as BRCA1mut. Overall, BRCA1met had a different gene expression profile, characterized by diffuse downregulation, whereas BRCA1mut showed a general upregulation (p < 0.0001). Both BRCA1-defective groups showed a slightly activated immune response mediated by interferon (IFN) gamma pathways.

Discussion

In conclusion, even if the expression profile of many genes related to DNA damage and repair system is shared between BRCA1mut and BRCA1met EOCs supporting that BRCA1met EOCs may benefit from PARPi therapies, our data demonstrate that BRCA1mut and BRCA1met EOCs show different expression profiles, suggesting a different mechanism of carcinogenesis that can be reflected in different responses to therapies and disease recovery.
Efficacy of traditional Chinese medicine on diabetic cardiomyopathy in animal models: a systematic review and meta-analysis
Authors: Hu Longxiao , Qian Longxin , Sun Aochuan , Cai Guida , Gao Yunxiao , Yuan Yue , Chen Xiaoxiao , Jiang Yunyao , Liu Jianxun , Ren Junguo
Published: October 2023

Background: Diabetic cardiomyopathy (DCM) is a severe complication of diabetes that can diminish the quality of life in patients and is a leading cause of death. Research has demonstrated the effectiveness of Traditional Chinese Medicine (TCM) in reducing blood sugar levels and protecting cardiovascular function in both animal models and clinical research studies. Nevertheless, the efficacy of TCM in animal models of DCM has not been analyzed systematically.

Method: We searched the following electronic bibliographic databases: Web of Science, PubMed, Cochrane Library, and CNKI(China National Knowledge Infrastructure). Studies that reported the efficacy of TCM in animals with DCM were included. The literature search was conducted using the terms. The data will be restricted from the year 2013 to 24 April 2023, 24 studies were included in the meta-analysis.

Result: A total of 24 Traditional Chinese Medicine interventions and 2157 animals met the inclusion criteria. The pooled data revealed that TCM interventions resulted in significant improvements in body weight (BW), heart weight (HW) to body weight ratio (HW/BW), triglyceride (TG) and cholesterol (TC) levels, ejection fraction (EF), fractional shortening (FS) and E/A ratio. Subgroup analysis and meta-regression revealed that the type of TCM, duration of intervention, method of modeling, and animal species were potential sources of heterogeneity.

Conclusion: TCM interventions were associated with significant improvements in body weight, heart weight to body weight ratio, triglyceride and cholesterol levels, left ventricular internal dimension in systole, ejection fraction, fractional shortening and E/A ratio. The heterogeneity in the results was found to be potentially due to the type of TCM, duration of intervention, method of modeling, and animal species, as shown in subgroup analysis and meta-regression.

Systematic Review Registration: identifier CRD42023402908
Exposure-response analyses of efzofitimod in patients with pulmonary sarcoidosis
Authors: Walker Gennyne , Adams Ryan , Guy Lauren , Chandrasekaran Abhijeeth , Kinnersley Nelson , Ramesh Pavithra , Zhang Lu , Brown Fran , Niranjan Vis
Published: October 2023

Background: Preliminary evidence for efficacy in pulmonary sarcoidosis has been shown for efzofitimod. Here we present supportive evidence of efficacy based on an exposure-response analysis.

Methods: Data from two studies (Phase 1, N = 24, single dose in healthy volunteers, and Phase 1b/2a, N = 25, multiple doses over 24 weeks in participants with pulmonary sarcoidosis) were used to build a population pharmacokinetic model. Using this model, the relationship between efzofitimod exposure and three prespecified efficacy parameters [mean daily oral corticosteroid (OCS) dose, percent-predicted forced vital capacity (ppFVC) and King’s Sarcoidosis Questionnaire-Lung (KSQ-Lung) score] was explored. Linear regression described the relationship of efzofitimod exposure and OCS reduction, ppFVC and KSQ-Lung score. Logistic regression related efzofitimod exposure to the probability of achieving a minimal clinically important difference for ppFVC and KSQ-Lung score. Due to the small study size, trends (not statistical significance) in relationships are reported.

Results: In patients with pulmonary sarcoidosis, as efzofitimod exposure increased, the mean daily OCS dose decreased, and ppFVC and KSQ-Lung score improved over baseline. The slope for all the endpoints by both linear and logistic regression showed an improving trend with increased exposure.

Conclusion: These preliminary findings of a positive exposure-response across multiple efficacy endpoints support the claim that proof of concept has been established for the use of efzofitimod in pulmonary sarcoidosis.

Clinical Trial Registration:clinicaltrials.gov, identifier NCT03824392
Assessing delivered pulse-energies by a nonlinear model
Authors: Rabinovitch Avinoam , Braunstein Doron , Aviram Ira , Smolik Ella , Biton Yaacov , Rabinovitch Revital , Thieberger Reuven
Published: October 2023

Short-duration and high-amplitude electric pulses have recently been used for two different biological tasks: stimulating physiological actions such as heart rate or defibrillation and invoking cell annihilation, as in cancer treatment or atrial fibrillation ablation, by electroporation. However, the physics behind the influence of such pulses has been controversial due to the linear methods used in the analyses. We present the results of a simple nonlinear model to study this situation. Results for the specific nonlinear model show that, below a certain pulse duration, stimulating threshold levels increase rapidly, while the delivered energies reach the lowest plateau. This renders former energy estimates based on linear models, which show a distinct minimum in the calculated delivered energy at a certain amplitude which is invalid for the real nonlinear case. It is notable that these results explain why short high-amplitude pulses are more beneficial to the patient than lower and longer ones in pacing. However, these pulses should not be too high, since no additional energy reduction is achieved and electroporation processes could occur. To further reduce the tissue burden, a train of pulses is necessary, but delivered energies become higher. Considering this case, we clarify the difficulty of reaching threshold at the end of the nth pulse for n > 2 not previously reached and find the “best” conditions for such a train of pulses.
Population structure and mixed reproductive strategies in Bipolaris maydis from single and multiple corn cultivars in Fujian Province, China
Authors: Dai Yuli , Gan Lin , Lan Chengzhong , Liu Xiaofei , Liu Wende , Yang Xiujuan
Published: October 2023

Bipolaris maydis is the pathogenic microorganism of southern corn leaf blight, a persistent biotic constraint responsible for substantial yield losses of corn worldwide. In the present study, 96 isolates from six representative fields growing single and multiple sweet corn cultivars in Pingnan, Fuqing, and Jian’ou in Fujian Province, which are characterized by different geographical characteristics and cropping patterns, were genetically analyzed using inter-simple sequence repeat (ISSR) markers to assess the impact of geographical origins and corn cultivars on B. maydis population differentiation. B. maydis isolates originated from diverse regions possessed higher genetic variety than those from single and multiple sweet corn cultivars. Phylogenetic analysis showed that the isolates from single and multiple sweet corn cultivars were randomly grouped into different clusters, with those from the same location tending to form clusters. A greater genetic differentiation among different geographical populations than between those from single and multiple sweet corn cultivars was observed by pairwise comparison. Hierarchical analysis indicated that among-population variation was higher when comparatively analyzed B. maydis populations from different locations than in those from single and multiple sweet corn cultivars. In conclusion, these results suggest that geographical origin acts a more considerable role in genetic differentiation of B. maydis than corn cultivar. Two divided genetic clusters were detected in the B. maydis populations from single and multiple sweet corn cultivars at the three locations in Fujian Province, with major genetic variation being derived within populations. The high haplotypic diversity and expected mating type ratio of 1:1 in combination with significant linkage disequilibrium suggested that a mixed reproductive strategy occurs in the B. maydis population in Fujian Province. This study will enrich the information on the role that geographical origins and corn cultivars play in the population structure of the pathogen as well as the reproductive strategies in B. maydis population in Fujian Province.
A study on the influencing factors and response strategies for young teachers from Taiwan to teach in universities in China: a push-pull-mooring model perspective
Authors: Wang Li , Miao Cong-Jin , Ye Jian-Hong , Huang Xin , Nong Liying , Nong Weiguaju
Published: October 2023

Introduction

A growing number of Taiwanese teachers are choosing to teach at universities in mainland China, but their jobs are not always stable. Therefore, this study aims to investigate the factors infuencing young teachers from Taiwan to teach in universities in China.

Methods

Twenty-seven young teachers from Taiwan with master’s or doctoral degrees who were willing to apply to work at universities in China and who were already teaching in China were invited to conduct in-depth interviews to collect research data.The interview data were coded and analyzed according to the Push-Pull-Mooring (PPM) Model.

Results and discussion

The results showed that the understanding of mainland Chinese universities among young Taiwanese teachers is not entirely consistent. Taiwanese teachers who previously studied in mainland China have a more comprehensive understanding of mainland Chinese universities, and some teachers have gained a superfcial understanding through academic exchanges between the two sides and information shared by friends.However,still,7% of the teachers have no understanding at all. Most young Taiwanese teachers indicate that they do not understand the talent recruitment policies of mainland Chinese universities. The push factors that infuence young teachers from Taiwan to teach at mainland universities are: Oversupply of teachers in Taiwan, poor environment for higher education in Taiwan, poor articulation of the cross-strait academic system, and four aspects of teacher retirement and re-employment in Taiwan. The pull factors are: Benefcial policies, salary, living environment, educational advantages and cultural dissemination in 5 areas. Mooring factors are divided into 3 aspects: personal factors, environmental factors and social factors.
Predicting obsessive-compulsive disorder episodes in adolescents using a wearable biosensor—A wrist angel feasibility study
Authors: Lønfeldt Nicole Nadine , Olesen Kristoffer Vinther , Das Sneha , Mora-Jensen Anna-Rosa Cecilie , Pagsberg Anne Katrine , Clemmensen Line Katrine Harder
Published: October 2023

Introduction

Obsessive-compulsive disorders (OCD) are marked by distress, negative emotions, mental processes and behaviors that are reflected in physiological signals such as heart rate, electrodermal activity, and skin temperature. Continuous monitoring of physiological signals associated with OCD symptoms may make measures of OCD more objective and facilitate close monitoring of prodromal symptoms, treatment progress and risk of relapse. Thus, we explored the feasibility of capturing OCD events in the real world using an unobtrusive wrist worn biosensor and machine learning models.

Methods

Nine adolescents (ages 10–17 years) with mild to moderate-severe OCD were recruited from child and adolescent mental health services. Participants were asked to wear the biosensor in the lab during conditions of rest and exposure to OCD symptom-triggering stimuli and for up to 8 weeks in their everyday lives and register OCD events. We explored the relationships among physiological data, registered OCD events, age, OCD symptom severity and symptom types. In the machine learning models, we considered detection of OCD events as a binary classification problem. A nested cross-validation strategy with either random 10-folds, leave-one-subject-out, or leave-week(s)-out in both layers was used. We compared the performance of four models: logistic regression, random forest (RF), feedforward neural networks, and mixed-effect random forest (MERF). To explore the ability of the models to detect OCD events in new patients, we assessed the performance of participant-based generalized models. To explore the ability of models to detect OCD events in future, unseen data from the same patients, we compared the performance of temporal generalized models trained on multiple patients with personalized models trained on single patients.

Results

Eight of the nine participants collected biosensor signals totaling 2, 405 h and registered 1, 639 OCD events. Better performance was obtained when generalizing across time compared to across patients. Generalized temporal models trained on multiple patients were found to perform better than personalized models trained on single patients. RF and MERF models outperformed the other models in terms of accuracy in all cross-validation strategies, reaching 70% accuracy in random and participant cross-validation.

Conclusion

Our pilot results suggest that it is possible to detect OCD episodes in the everyday lives of adolescents using physiological signals captured with a wearable biosensor. Large scale studies are needed to train and test models capable of detecting and predicting episodes.

Clinical trial registration

ClinicalTrials.gov: NCT05064527, registered October 1, 2021.
Exploring configurations of social determinants for enhancing older adult health in China: an fuzzy-set qualitative comparative analysis based on 31 provinces in China
Authors: Zhang Songbiao , Wang Xining , Wang Huilin
Published: October 2023

With China’s aging population on the rise, addressing population aging has become a national priority, particularly focusing on improving older adult health. This study employs the social determinants of health framework, considering China’s unique macro-social, economic, policy, healthcare, and family cultural factors, to develop a framework for understanding the social determinants of health for older adult in China. Using the fsQCA method and a configurational perspective, the complex relationship between social determinants of health and older adult health status is examined. The findings indicate that individual social determinants alone are insufficient for achieving high levels of older adult health. Instead, three configurations of social determinants have been identified as conducive to high older adult health: Economic Development-Environment – Cultural Dominant Type, Socio-Economic Development – Older Adult Security – Environment – Cultural Dominant Type, and Economic Development Dominant Type. These configurations offer diverse pathways for enhancing older adult health. Conversely, the study identifies two configurations associated with low older adult health levels, exhibiting an asymmetric relationship with the configurations resulting in high older adult health levels. Moreover, economic development consistently emerges as a core condition across all three configurations associated with high older adult health levels, while two configurations associated with low older adult health lack this core condition. These findings underscore the universal contribution of enhancing economic development to improving older adult health.
The psychobiology of child and parental stress and the subjective perception of parental stress in a clinical sample of children
Authors: Melinder Annika , Brænden Astrid , Lebena Andrea , Olsen Faresjö Åshild , Theodorsson Elvar , Coldevin Marit , Stubberud Jan , Zeiner Pål
Published: October 2023

Parental stress may influence the assimilation of treatment strategies and affect a child's recovery trajectory. Thus, assessing parental stress is crucial for children requiring psychiatric care. The Parenting Stress Index (PSI) is widely utilized to gauge perceived parental stress. However, since the PSI does not quantify cortisol concentration (i.e., a biological marker for stress), it is vital to ascertain the alignment between these indicators. Moreover, understanding the correlation in cortisol concentrations between parents and children in clinical contexts can refine assessment and diagnostic methodologies. In an outpatient sample [mean age (Mage) = 9.68 years], we examined the correlation between hair cortisol concentration (HCC) in 60 pairs of parents and children, analyzed the relationship between PSI scores and parent HCC (n = 65), and used a regression model to probe the influence of child HCC and PSI scores on parent HCC (n = 63). The results showed a significant relationship between parent and child HCC (p < 0.001). The “Distraction and Hyperactivity” PSI subscale correlated significantly with parent HCC (p = 0.02). None of the PSI scores correlated with child HCC (p ≥ 0.07). The regression model, accounting for 44% of the variance, demonstrated that only child HCC significantly predicted parent HCC (p < 0.001), while the “Distraction and Hyperactivity” subscale did not.
Assessment of social demand for environmental and cultural heritage preservation: evidence from a discrete choice experiment in Tunisia
Authors: Missaoui Sameh , Rahmani Djamel , Thabet Chokri , Feás Jacobo , Gíl José María , Akaichi Faical
Published: October 2023

Weighing cultural legacies is crucial to better understand the opportunity costs of lagoon restoration. It may be necessary for local populations whose wellbeing and culture are closely linked to heritage. This paper investigates the preferences and willingness to pay (WTP) of local fishermen for contributing to the restoration of the Bizerte lagoon (Tunisia, North Africa) and the management of the Manzel Abderrahmen harbor through the implementation of the EcoPact project. For this purpose, a discrete choice experiment (DCE) survey was conducted in the port with 50 local fishers. The results of this work represent a particular contribution to the literature as they offer a different perspective on the willingness to pay for the benefits of Cultural Bequest. Manzel Abderrahmen fishermen view “port organization” as an economic, cultural, and recreational attribute that drives their choices. The fishermen showed their willingness to accept all the taxes mentioned in the questionnaire and to increase the actual tax (9%) up to 13% over 5 years to complete the design of their port. This suggests that decision-makers should be aware of the omitted legacy values that could influence subsequent decision-making.
Technology for whom? Solar irrigation pumps, women, and smallholders in Nepal
Authors: Shrestha Gitta , Uprety Labisha , Khadka Manohara , Mukherji Aditi
Published: October 2023

Agricultural technologies are often promoted as a medium for women’s economic empowerment, which can transform unequal gender relations in rural agrarian societies. This paper investigates three solar irrigation pump (SIP) schemes implemented by state and non-state actors and examines their impacts on women and marginal farmers. We utilize a theory of change framework intended to evaluate the effectiveness of livelihood interventions and guide the design of gender transformative interventions. Our analysis relies on 63 qualitative interviews, 9 key informant interviews and 4 telephonic interviews with social mobilisers from the Saptari District in Nepal. The findings shed light on the unequal social and gender relations that have skewed the adoption and benefits of SIP technology. Gender and social inequalities persist, with limited adoption and benefit of SIP among women and smallholders. Women’s involvement in strategic decisions related to SIP adoptions, installations and usages is limited. This study underscores the importance of strategic interventions that foster meaningful women’s empowerment and ensure equitable distribution and benefits from SIP technology. Assessing the effectiveness of SIPs in empowering women, it is crucial to consider whether the resulting access, ownership, or decision-making opportunities challenge, reinforce, or reproduce unequal gender and social relations.
Gender differentials among small scale irrigation farmers’ income: empirical evidence from cabbage farmers in KwaZulu-Natal, South Africa
Authors: Mkuna Eliaza , Wale Edilegnaw
Published: October 2023

Introduction

Agricultural productivity and income disparities prevail between male and female farmers in Sub-Saharan Africa. South Africa is not an exception to this ominous reality.

Methodology

Using data from smallholder irrigation farmers in KwaZulu-Natal, South Africa, this study analyzed the gender on-farm income gap by applying the Blinder-Oaxaca (OB) decomposition framework.

Results

The findings indicate that there is a significant difference in farm income between male and female farmers. Male farmers earn significantly higher on-farm income than female farmers by about R26,788/cropping season.

Discussion

The findings suggest that existing and future programs should focus on institutional factors (land tenure) that affect access to resources and services. In addition to strategies to empower women, interventions to reduce the gender-induced farm income gap should focus on improving access to resources and services such as land with tenure security, agricultural input and output markets, training, information, and credit. Increasing the resource endowment and access to services by the female-managed farms is likely to significantly close the observed gender-induced farm income gap and improve the well-being of female farmers and their households.
Self-organization for community resilience in an invisible agricultural community
Authors: Erwin Anna , Silva Chelsea A. , Ma Zhao
Published: October 2023

This study investigates how self-organizing efforts by residents of informal settlements, primarily migrant and informal farmworkers, shape community resilience in Majes, a water-scarce irrigation district in the Atacama Desert of Peru. We collected 45 semi-structured interviews with residents and authorities in Majes and analyzed findings through a framework of self-organizing. Analyses revealed that self-organizing by residents of informal settlements incorporated the three components of White’s theory of Community Agency and Community Resilience, which contends that marginalized communities increase resilience by fostering a commons praxis, practicing a prefigurative politics, and developing opportunities for economic autonomy. We also found that residents self-organized into associations to increase access to resources, resulting in increased resilience. However, certain fees, corruption, and undemocratic decision-making processes can be detrimental to self-organizing. Results expand existing theories of self-organization and community resilience by highlighting how residents of informal settlements in agricultural spaces collectively organize to increase their resilience. Findings also begin to reframe narratives that describe migrants and farmworkers as powerless in the face of water scarcity, climate change, and other social-ecological risks.
Dynamic Equivalent Modeling of a Large Renewable Power Plant Using a Data-Driven Degree of Similarity Method
Authors: Liao Mengjun , Zhu Lin , Hu Yonghao , Liu Yang , Wu Yue , Chen Leke
Published: October 2023

This paper aims to develop a novel method for the dynamic equivalence of a renewable power plant, ultimately contributing to power system modeling and enhancing the integration of renewable energy sources. In order to address the challenge posed by clusters of renewable generation units during the equivalence process, the paper introduces the degree of similarity to assess similarity features under data. After leveraging the degree of similarity in conjunction with data-driven techniques, the proposed method efficiently entails dividing numerous units in a large-scale plant into distinct clusters. Additionally, the paper adopts practical algorithms to determine the parameters for each aggregated cluster and streamline the intricate collector network within the renewable power plant. The equivalent model of a renewable power plant is thereby conclusively derived. Comprehensive case studies are conducted within a practical offshore wind plant setting. These case studies are accompanied by simulations, highlighting the advantages and effectiveness of the proposed method, offering an accurate representation of the renewable power plant under diverse operating conditions.
Climatic Effects on Position and Dynamics of Upper Open Forest Boundary in Altay and Western Sayan in the Last 60 Years
Authors: Moiseev Pavel A. , Nizametdinov Nail’ F.
Published: October 2023

The upper treeline ecotone is a global and typically climate-dependent phenomenon. Its elevation is usually coupled with the thermal limitations of tree growth. The air temperature rise connected with global warming is assumed as the main cause of treeline upslope shifts in the last century. It has been found that the treeline elevation also correlates with the distance from the coastline and the aridity or continentality of the climate or the mass elevation effect. However, previous and contemporary publications have not explained how the upper treeline position directly couples with climate parameters. Often, this has been restricted by a lack of climate measurements and spatial data. In our study, we obtained data from 339 regional weather stations for 1964–1974 and interpolated them to Altay and Western Sayan using regional DEMs and a specially developed regression model. Moreover, we semiautomatically identified the elevational position of the upper open forest boundary (OFB) (crown closure > 10%) on the slopes of 30 mountains in Altay and Western Sayan in 1960 and 2020. We took into account the slope aspect and edaphic constraints. The obtained data allowed us to undertake a regression analysis of the dependence of the OFB elevation on climatic parameters. As a result, we found that, in the 1960s, at OFB elevations rising from the outer to the inner parts of the study area to approximately 500–700 m, the summer air temperature and precipitation linearly decreased, but the summer sunshine duration increased. In the multiple regression analysis, including the climatic parameters as independent variables and the OFB elevation as a dependent variable, significant relations were found only for the combination of air temperature and sunshine duration. We assume that the OFB elevation is determined not only by the air temperature but also by the direct solar irradiation level, changing with latitude and cloudiness. We also found that the ratio between the OFB elevation on the northern and southern slopes varied with respect to latitude. The spatial analysis of OFB shifts in 1960–2020 revealed significant differences in its value in the central (80–90 m) and outer parts of the study area (110–130 m). We suppose that the OFB advance over the past 60 years has local specificity associated with the peculiarities of the climatic changes (summer temperature rise, precipitation decrease, and sunshine duration increase) in different parts of Altay and Western Sayan. Our results highlight the need to clearly determine climatic parameters when forecasting woody vegetation reactions to future climate changes.
Urban Carbon Price Forecasting by Fusing Remote Sensing Images and Historical Price Data
Authors: Mou Chao , Xie Zheng , Li Yu , Liu Hanzhang , Yang Shijie , Cui Xiaohui
Published: October 2023

Under the strict carbon emission quota policy in China, the urban carbon price directly affects the operation of enterprises, as well as forest carbon sequestration. As a result, accurately forecasting carbon prices has been a popular research topic in forest science. Similar to stock prices, urban carbon prices are difficult to forecast using simple models with only historical prices. Fortunately, urban remote sensing images containing rich human economic activity information reflect the changing trend of carbon prices. However, properly integrating remote sensing data into carbon price forecasting has not yet been investigated. In this study, by introducing the powerful transformer paradigm, we propose a novel carbon price forecasting method, called MFTSformer, to uncover information from urban remote sensing and historical price data through the encoder–decoder framework. Moreover, a self-attention mechanism is used to capture the intrinsic characteristics of long-term price data. We conduct comparison experiments with four baselines, ablation experiments, and case studies in Guangzhou. The results show that MFTSformer reduces errors by up to 52.24%. Moreover, it outperforms the baselines in long-term accurate carbon price prediction (averaging 15.3%) with fewer training resources (it converges rapidly within 20 epochs). These findings suggest that the effective MFTSformer can offer new insights regarding AI to urban forest research.
Illuminating Plant Community Assembly on Karst Mountain Road Slopes through Plant Traits and Environmental Filters
Authors: Qin Kunrong , Qin Hua , Wang Zizhuo , Lin Li , Zhu Haoxiang , Wang Haiyang
Published: October 2023

Understanding how assembly processes shape local plant assemblages from the potential species pool is crucial for biodiversity conservation and revegetation. Mountainous regions are global biodiversity hotspots with high levels of diversity, concentration, and vulnerability. Road construction in these areas poses ecological challenges, including habitat loss and reduced biodiversity. Feature-based ecology highlights non-biological filtering as a key driver of habitat-specific community formation. Analyzing trait structures and their association with the environment can reveal community assembly processes under specific environmental conditions. However, quantifying species-environment-traits interactions during community assembly on roadside slopes is still underexplored. In our study, 76 naturally recovered roadside slopes, 656 self-established plant communities and 113 plant species across ten functional traits, along with their environmental associations, in the karst mountain region of southwestern China, were examined. Our findings show that there are still abundant native plants with colonization potential settled on steep roadside slopes in karst mountain areas. Diffusion constraints stemming from distance to the core species pool, elevation, and differences in adjacent vegetation types emerged as key factors causing variations in species composition of self-established communities. The slope environment exerts strong selective pressures leading to a convergence pattern in traits related to dispersal and colonization while showing a divergence pattern in traits linked to competitive strategies and regeneration. These findings identify critical functional traits and environmental factors shaping roadside plant communities and illustrate the predictability of environmental filtering and fundamental community assembly. Overall, our study sheds light on the intricate interactions among assembly processes, functional traits, and environmental factors driving local plant assemblages in mountainous regions, providing insights for effective diversity conservation and revegetation strategies.
Barcoding Hymenoptera: 11 Malaise Traps in Three Thai Forests: The First 68 Trap Weeks and 15,338 Parasitoid Wasp Sequences
Authors: Quicke Donald L. J. , Hebert Paul D. N. , Pentinsaari Mikko , Butcher Buntika A.
Published: October 2023

We report the results of DNA barcoding week-long Malaise trap catches from 11 sites in three Thai conservation areas, concentrating on the parasitoid Hymenoptera, particularly the superfamily Ichneumonoidea. From a total of 15,338 parasitoid wasp sequences, 13,473 were barcode compliant and could be assigned to a family based on morphology and sequence data. These collectively represented 4917 unique BINs (putative species) in 46 families, with the Scelionidae, Ichneumonidae, Eulophidae, Braconidae and Platygastridae being, by far, the most abundant. Spatial proximity had a strong positive effect on the numbers of BINs shared between traps.
The Initial Hepatitis B Virus-Hepatocyte Genomic Integrations and Their Role in Hepatocellular Oncogenesis
Authors: Michalak Tomasz I.
Published: October 2023

Hepatitis B virus (HBV) remains a dominant cause of hepatocellular carcinoma (HCC). Recently, it was shown that HBV and woodchuck hepatitis virus (WHV) integrate into the hepatocyte genome minutes after invasion. Retrotransposons and transposable sequences were frequent sites of the initial insertions, suggesting a mechanism for spontaneous HBV DNA dispersal throughout the hepatocyte genome. Several somatic genes were also identified as early insertional targets in infected hepatocytes and woodchuck livers. Head-to-tail joints (HTJs) dominated amongst fusions, indicating their creation by non-homologous end-joining (NHEJ). Their formation coincided with the robust oxidative damage of hepatocyte DNA. This was associated with the activation of poly(ADP-ribose) polymerase 1 (PARP1)-mediated dsDNA repair, as reflected by the augmented transcription of PARP1 and XRCC1; the PARP1 binding partner OGG1, a responder to oxidative DNA damage; and increased activity of NAD+, a marker of PARP1 activation, and HO1, an indicator of cell oxidative stress. The engagement of the PARP1-mediated NHEJ repair pathway explains the HTJ format of the initial merges. The findings show that HBV and WHV are immediate inducers of oxidative DNA damage and hijack dsDNA repair to integrate into the hepatocyte genome, and through this mechanism, they may initiate pro-oncogenic processes. Tracking initial integrations may uncover early markers of HCC and help to explain HBV-associated oncogenesis.
The Physiological and Pathological Role of Acyl-CoA Oxidation
Authors: Szrok-Jurga Sylwia , Czumaj Aleksandra , Turyn Jacek , Hebanowska Areta , Swierczynski Julian , Sledzinski Tomasz , Stelmanska Ewa
Published: October 2023

Fatty acid metabolism, including β-oxidation (βOX), plays an important role in human physiology and pathology. βOX is an essential process in the energy metabolism of most human cells. Moreover, βOX is also the source of acetyl-CoA, the substrate for (a) ketone bodies synthesis, (b) cholesterol synthesis, (c) phase II detoxication, (d) protein acetylation, and (d) the synthesis of many other compounds, including N-acetylglutamate—an important regulator of urea synthesis. This review describes the current knowledge on the importance of the mitochondrial and peroxisomal βOX in various organs, including the liver, heart, kidney, lung, gastrointestinal tract, peripheral white blood cells, and other cells. In addition, the diseases associated with a disturbance of fatty acid oxidation (FAO) in the liver, heart, kidney, lung, alimentary tract, and other organs or cells are presented. Special attention was paid to abnormalities of FAO in cancer cells and the diseases caused by mutations in gene-encoding enzymes involved in FAO. Finally, issues related to α- and ω- fatty acid oxidation are discussed.
Facade-Based Bicelles as a New Tool for Production of Active Membrane Proteins in a Cell-Free System
Authors: Goncharuk Marina V. , Vasileva Ekaterina V. , Ananiev Egor A. , Gorokhovatsky Andrey Y. , Bocharov Eduard V. , Mineev Konstantin S. , Goncharuk Sergey A.
Published: October 2023

Integral membrane proteins are important components of a cell. Their structural and functional studies require production of milligram amounts of proteins, which nowadays is not a routine process. Cell-free protein synthesis is a prospective approach to resolve this task. However, there are few known membrane mimetics that can be used to synthesize active membrane proteins in high amounts. Here, we present the application of commercially available “Facade” detergents for the production of active rhodopsin. We show that the yield of active protein in lipid bicelles containing Facade-EM, Facade-TEM, and Facade-EPC is several times higher than in the case of conventional bicelles with CHAPS and DHPC and is comparable to the yield in the presence of lipid-protein nanodiscs. Moreover, the effects of the lipid-to-detergent ratio, concentration of detergent in the feeding mixture, and lipid composition of the bicelles on the total, soluble, and active protein yields are discussed. We show that Facade-based bicelles represent a prospective membrane mimetic, available for the production of membrane proteins in a cell-free system.
Spatial Transcriptomic Analysis Reveals Regional Transcript Changes in Early and Late Stages of rd1 Model Mice with Retinitis Pigmentosa
Authors: Zhou Ying , Sheng Yuqi , Pan Min , Tu Jing , Zhao Xiangwei , Ge Qinyu , Lu Zuhong
Published: October 2023

Retinitis pigmentosa (RP) is the leading cause of inherited blindness with a genetically heterogeneous disorder. Currently, there is no effective treatment that can protect vision for those with RP. In recent decades, the rd1 mouse has been used to study the pathological mechanisms of RP. Molecular biological studies using rd1 mice have clarified the mechanism of the apoptosis of photoreceptor cells in the early stage of RP. However, the pathological changes in RP over time remain unclear. The unknown pathology mechanism of RP over time and the difficulty of clinical treatment make it urgent to perform more refined and spatially informed molecular biology studies of RP. In this study, spatial transcriptomic analysis is used to study the changes in different retinal layers of rd1 mice at different ages. The results demonstrate the pattern of photoreceptor apoptosis between rd1 mice and the control group. Not only was oxidative stress enhanced in the late stage of RP, but it was accompanied by an up-regulation of the VEGF pathway. Analysis of temporal kinetic trends has further identified patterns of changes in the key pathways of the early and late stages, to help understand the important pathogenesis of RP. Overall, the application of spatial transcriptomics to rd1 mice can help to elucidate the important pathogenesis of RP involving photoreceptor apoptosis and retinal remodeling.