bluuebunny/crossref_metadata_2025 huggingface dataset:
Application of mathematical methods in pharmacology
Authors: Mazakova Aigerym , Jomartova Sholpan , Mazakov Talgat , Ziyatbekova Gulzat , Tursynbai Aisulu
Published: October 2024

The application of mathematical methods in pharmacology is relevant for the development of accurate models of drug action and optimisation of their dosing, which increases the effectiveness of treatment and reduces the risks of side effects, and accelerates and cheapens the process of developing new drugs. The purpose of this research is to explore the application of mathematical methods in pharmacology to optimise drug development and improve drug efficacy. The methods used include analytical method, classification method, functional method, statistical method, synthesis method. This research covers the main aspects of using mathematical modelling in pharmacology, covering a variety of issues that arise at different stages of drug development. Specific examples of using mathematical modelling to solve these problems are presented. Various approaches to modelling the pharmacokinetics (PK) of drugs, and the analysis of their absorption, distribution and excretion are reviewed. Mathematical methods for analysing efficacy and safety and approaches to determining the therapeutic window of a drug are discussed. The research into the application of mathematical methods in pharmacology is of practical significance as it contributes to the development of more accurate PK and pharmacodynamic (PD) models, optimisation of drug dosing and improved predictive accuracy, leading to the development of more effective and safer drugs.
Results on Riemann Zeta functions using compositions
Authors: Alegri Mateus , López-Bonilla José Luis , Reddy P. Siva Kota
Published: October 2024

The main results of our paper are relations involving sums of Multiple Zeta Riemann functions (MZVs). Using the techniques described here, we found a simple relation for z({a}n) = z(a, a, ..., a^n) for a positive integer n and a complex a where Re{a} > 1.
Effect of Mitochondrial DNA T15663C Mutation on Type 2 Diabetes Mellitus and Cataract Patients, Molecular Dynamics Simulation Study
Authors: Rahmadanthi Fanny Rizki , Fariz Maulana Ahmad , Destiarani Wanda , Gaffar Shabarni , Maksum Iman Permana
Published: October 2024

Diabetes mellitus is a metabolic disease characterized by hyperglycemia. Type 2 diabetes mellitus patients are known to have mutations in their mitochondrial DNA (mtDNA). mtDNA easily undergoes mutations because it does not have histone proteins for protection and lacks a proofreading mechanism during its replication. The mtDNA mutations T15663C found in type 2 diabetes mellitus patients sufferers with a cataract disease. This mutation was found to occur in the cytochrome b gene, one of the gene in the complex III respiratory chain. In this study we investigate the effect of this mutation on the structure of cytochrome b using molecular dynamics simulations using PDB ID: 5XTE as a template and carrying out simulations for 250 ns. The models of wild type and mutant protein structure were constructed using CHARMM-Gui so that, the protein was looked like in the mitochondrial membrane. The results of the molecular dynamics simulation show that the potential energy of the wild type model is lower than the mutant model, the RMSD value of the wild type model is more stable at 114 - 180 ns, and the RMSF value in the wild type model does not fluctuate as much as the mutant model. In addition, the hydrogen bond (H bond) analysis of the mutant model has a higher H bond number than the wild type model, which means that the mutant model is more rigid. The simulation results were visualized using VMD, and new hydrogen bonds were found in the mutant model.
HIGHLIGHTS

Mitochondrial mutations can lead to many diseases such as type 2 diabetes mellitus and cataracts.
Molecular dynamics simulations can be used to see the differences between wild type and mutant structures.
Potential energy, Root Mean Square Deviation (RMSD), Root Mean Square Fluctuation (RMSF) and hydrogen bond (H bond) analysis commonly used to analyze simulation results, such as the stability or rigidity of the structure.

GRAPHICAL ABSTRACT
Cuando la misión pasa a ser propósito: medidas para un emprendimiento sostenible y equitativo
Authors: Bastida María , Vaquero García Alberto , Vázquez Taín Miguel Á.
Published: October 2024

Este trabajo ha obtenido el 1.er Premio Estudios Financieros 2024 en la modalidad de Contabilidad y Sostenibilidad.
Este estudio afronta al «trilema» de cómo fomentar el emprendimiento, cómo orientarlo hacia negocios sostenibles en un contexto cada vez más exigente con esta necesidad y cómo impulsar la actividad emprendedora entre las mujeres, cuya limitada participación supone una pérdida de oportunidad para el desarrollo económico. Para abordar estos retos, se centra en el emprendimiento en la economía social y solidaria (ESS), explorando cómo los principios de sostenibilidad se integran en sus modelos de negocio y cómo esta integración influye en la decisión de emprender.
Se realizan dos estudios interrelacionados entre emprendedores para identificar patrones y diferencias en las preferencias hacia los modelos de negocio de la ESS, evaluando las motivaciones, percepciones y barreras hacia este tipo de emprendimiento. Los resultados revelan un amplio consenso sobre la viabilidad de las organizaciones de ESS como plataformas para el emprendimiento, resaltando sus características de sostenibilidad. Se encontraron diferencias significativas en el comportamiento entre hombres y mujeres. Los hombres manifiestan preocupaciones por las dificultades inherentes a la creación de empresas y por las limitaciones que los modelos arraigados en la ESS podrían presentar para materializar una idea de negocio. Por su parte, las mujeres muestran una mayor adhesión a los principios y valores subyacentes a la cultura organizativa de las organizaciones de ESS. Estos resultados sugieren la necesidad de desarrollar estrategias de impulso de la actividad emprendedora diferenciadas que consideren las variaciones en motivaciones y percepciones entre unos y otras. Dichas políticas deberían mejorar el conocimiento de los modelos de ESS y proporcionar apoyo efectivo para fomentar un compromiso más profundo con estos modelos, contribuyendo a un desarrollo empresarial más sostenible y equitativo a largo plazo.
Operativo guerrillero en la zona rosa
Authors: C. A.
Published: October 2024

No abstract available.
ECA Estudios Centroamericanos, Vol. 40, No. 441-442, 1985: 529-535.
Errores en la interpretación de la radiografía de tórax en el lactante: ¿qué tenemos que saber de la técnica?
Authors: Pérez Marrero Lizbet
Published: October 2024

La radiografía de tórax sigue siendo fundamental para la evaluación de patologías torácicas en lactantes. Antes de iniciar su interpretación, muchos autores sugieren revisar la técnica radiológica, ya que a esta edad se presentan varias particularidades técnicas que deben tenerse en cuenta para evitar errores interpretativos y no confundir hallazgos técnicos con patologías. Entre estas particularidades técnicas se deben evaluar: el centraje transversal o rotación, el centraje longitudinal o posición lordótica, el grado de inspiración, la posición de la vía aérea superior, la penetración o exposición de la radiografía, tipos de proyecciones y el movimiento. El objetivo de esta revisión es comentar y ejemplificar las peculiaridades técnicas que presenta la radiografía de tórax en lactantes y que pueden llevar a interpretaciones erróneas.
Assessment of genetic diversity using microsatellite markers and milk productivity of Mugalzhar horses
Authors: Kassymbekova Sh.N. , Iskhan K. Zh. , Rzabaev S. S. , Bimenova Zh. Zh. , Kabylbekova D. I. , Tursunkulov S. A.
Published: October 2024

Background and Aim. At "Chromtau Beef" LLP in Aktobe region, Mugalzhar horse breed is primarily used for meat and milk production. This largely depends on improving breeding techniques through introduction genetic achievements in farm and identifying and realizing genetic potential for productivity and breeding quality in production. The purpose this research was to study the zootechnical and genetic characteristics of modern population horses Mugalzhar breed using DNA markers. Materials and Methods. In this study, we studied polymorphism microsatellite markers to assess genetic differentiation sample Mugalzhar horses. Data on 17 microsatellite loci 20 heads horses from Aktobe population were used. The results were compared using GenAlEx 6.503 program: FST was calculated using matrix distances between alleles; according to matrix distances between genotypes.Results. The study zootechnical characteristics revealed that horses did not differ from breed standard in measurements. The milk production linebred mares varied considerably during 105 days lactation (average milk production Bekzat, Bau and Paluantora mares was 1701.0, 1492.05 and 1431.15 litres, respectively). Higher productivity was observed at 2-3 months lactation, after which milk yields gradually decreased and more sharply towards end lactation. Estimates genetic differentiation breed were obtained: FST = 0.028, matrix distances between genotypes = 0.015. A high correlation of FST and GD with Nei polocus differentiation scores was found (100). The inbreeding coefficient Fis for studied loci was found to have negative value (-0.014), which shows predominance heterozygous genotypes in Mugalzhar breed horse population.Conclusion. The coefficients variability (Cv) for both size and live weight are low, indicating uniformity horses. Our research has shown that Mugalzhar mares from different lines have different levels milk production. Simulation Mugalzhar breed with GD close to zero resulted in increase in number alleles per locus by 40%. It is advisable to use results obtained in development breeding measures topreserve diversity of breed.
Improvement of direct microscopy method for differential diagnosis of skin mycoses
Authors: Bailina G. E. , Nesipbaeva A. E. , Kukhar E. V.
Published: October 2024

Background and Aim.In the practice of veterinary doctors, a number of methods for diagnosing dermatomycoses are used, methods of direct and luminescent microscopy are undeservedly ignored. Сomparative analysis of staining methods for improving the method of direct microscopy, rapid and reliable detection of spores and mycelium in biomaterial, identification of pathogens and differential diagnosis of skin mycoses is of crucial importance for the effective treatment of animalsMaterials and Methods. 47 clinical samples of wool and skin taken from farm animals were examined for dermatomycetes. Diagnosis was performed using direct microscopy, fluorescence microscopy with calcofluor, and culture medium culture Saburo.
Results. During the study of 47 samples of biological material, it was found that during microscopy the pathogen was detected in 10 cases (21.3%), during KOH microscopy - in 15 cases (29.9%), during KOH microscopy with other dyes in 11 cases (23.4%), during KOH microscopy with color calcofluor in 25 cases (53.2%). The efficiency of the KOH microscopy method with white calcofluor in comparison with direct microscopy was 60% higher, in comparison with KOH microscopy with other dyes - by 56%, classical KOH microscopy by 43.8%. By the culture method, pathogens were detected in 28 cases (59.6%), of which 7 Trichophyton  spp., 1 Microsporum spp., 14 Aspergillius spp., 6 yeast. Growth was absent in 19 samples (40.4%), bacteria were detected in 3 samples (6.3%). In comparison with  КOH microscopy with calcofluor white, positive results were confirmed in 89.3%.Conclusion. The use of coloring with various dyes of morphological elements of micromycetes in pure cultures allows you to identify mycelial hyphae of various thicknesses, spores, conidia, other morphological structures and carry out a quick preliminary identification of dermatomycetes and opportunistic mold fungi in smears.
Hubungan Profil Manusia Digital dengan Pendidikan Agama Kristen
Authors: Nainggolan Deklay , Supit Sugijanti
Published: October 2024

This research aims to determine the extent of the relationship between digital humans and PAK (Christian religious education). This research was conducted using the literature study method. The research results show that current and future technological advances are not scary. How humans can survive and adapt to technological advances depends on humans themselves. PAK should be a protector for Christians in the face of advances in digital technology that are ready to prey, but there is no need to make technological advances a scourge that must be shunned. Technological advances should be responded to well and used as a friend in PAK teaching.
Synthesis, Characterization of Some New Dimer Nitrone Derivatives from Dapsone, Their Use as Initiators for Polymerization
Authors: Ahmed A. A. , Turki A. A. , Hanoosh W. S.
Published: October 2024

In order to address the demand for effective anionic initiators in polymerization processes, this work investigates the synthesis and characterisation of new dimer nitrone derivatives produced from dapsone. The aim is to close the existing gap in the acrylonitrile polymerization process by using nitrones as initiators. The process entails producing the necessary dimer nitrones by oxidizing with peroxy acid after generating dimer imines through condensation processes. Techniques including FTIR, 1H NMR, and MS were used to conduct the characterization. Evaluating these chemicals' potential as bulk polymerization initiators was the goal. The successful creation of polymers was revealed by the results, indicating that these dimer nitrones are efficient initiators of anionic polymerization, which may improve polymer synthesis techniques.
Performance and Selection of Short Life and High Yield Black Rice M3 Gamma Ray Irradiation 200 Gray
Authors: Handayani Rizky , Nandariyah Nandariyah , Parjanto Parjanto , Riyatun Riyatun , Sutarno Sutarno
Published: October 2024

Black rice is one of Indonesia's genetic resources as a functional food source. Black rice is rich in antioxidants, iron, amino acids, potassium and calcium. Long lifespan and low yields are obstacles that reduce farmers' interest in cultivation. To overcome this weakness, mutation induction was carried out with 200 Gray gamma ray irradiation. This research aims to determine the performance and select plants with early maturity and high yields on M3 black rice irradiated with gamma rays. The research was conducted from March 2023 to June 2023 in the rice fields of Pakahan Village, Jogonalan, Klaten. The selection method uses pedigree with a completely randomized design without replication. The materials used in this research were M2 mutant black rice seeds resulting from 200 Gray gamma ray irradiation and Cempo Ireng elders as control plants. The results of the research revealed that the M3(GH8')-12 line had an average difference with Cempo Ireng in the characteristics of flowering age, productive tillers, seed weight per hill, and grain yield. So the 200 Gray gamma ray irradiation treatment had an effect on the lifespan and results shown in the M3(GH8')-12 line. 17 plants of the M3 line were obtained from selection based on the criteria of flower age and high yield. The M3(GH8')-12-1-2 line can be further developed to flower at 64 DAP with seeds weight per plant of 102.2 grams.
Potential of Brotowali, Red Ginger, and Propolis Extract Towards Productivity of Broiler Chicken
Authors: Oktafiani Anggita , Putri Dwi Desmiyeni , Nurhayati Nurhayati
Published: October 2024

Indonesia is a country where most of the population's income comes from agriculture and livestock. In the poultry sector, especially commercial broiler chickens are still the main priority for meeting people's animal protein needs. This research aims to determine the effectiveness of using brotowali extract, red ginger, and propolis as herbal ingredients used in drinking water towards productivity of broiler chicken. This research used a Completely Randomized Design (CRD) with 5 treatments and 5 replications and each replication consisted of 5 broiler chickens. The treatment consisted of P0 = drinking water without adding extract (control), P1 = drinking water + 0.5% brotowali extract and 0.5% propolis extract, P2 = drinking water + 0.5% red ginger extract and 0, 5% propolis extract, P3= drinking water + 0.5% brotowali extract, 0.5% red ginger extract and 0.5% propolis extract, P4= drinking water + 1% propolis extract. Variables observed in productivity include consumption ratio, body weight, and conversion ratio. The results showed that the addition of brotowali extract, red ginger, and propolis given singly, a combination of 2 ingredients and a combination of 3 ingredients had a significant effect (P<0.05) on body weight gain and feed conversion. However, it has no real effect on ration consumption. The conclusion of this research is that the use of brotowali extract, red ginger, and propolis given singly, a combination of 2 ingredients and a combination of 3 ingredients in drinking water can increase the productivity of broiler chicken.
Effect of Adding Furfural Residues, Phosphate Fertilization, and Organic Matter on Soil Characteristics and Increasing Available Phosphorus
Authors: Dakhel Doaa Hassan , Imran Rashad Adel
Published: October 2024

Laboratory experiment was conducted in department of Soil Science and Water Resources collage of Agriculture, University of Basrah for the purpose of studying the effect of adding Furfural, phosphorus and organic matter on availability of phosphorus in the soil. Three levels of furfural were used (0, 600, and 1200 mg kg-1), three levels of phosphate fertilization in the form of urea phosphate fertilizer (0, 500, and 1000 mg P kg-1), and two levels of organic matter from cow waste (0 and 40 tons ha-1). Individually or overlapping with each other, soil samples were incubated intervals of 15 and 30 days, and after the end of the incubation period, a sample was taken from each treatment, and were estimate pH, available phosphorus, and organic matter. The results showed no significant effect of the treatments on soil pH values ​​after 15 days of incubation, while there was a significant effect after 30 days. Adding a level of 1200 mg kg-1 of furfural, 1000 mg p kg-1 of phosphate fertilizer, and 40 tons ha-1 of organic matter gave a significantly increase in the available of phosphorus in the soil, whether at an incubation period of 15 days or 30 days. At the same time, it was found that adding levels of high levels of furfural and organic matter led to an increase in the organic matter content in the soil, while the organic matter content in the soil decreased with increasing levels of phosphate fertilizer. The results indicate that adding furfural, phosphate fertilizer, and organic fertilizer can significantly increase the availability phosphorus in calcareous soil.
Interaction of Genotype and Environment on the Productivity of 12 Genotypes of Rice (Oryza sativa L.) using AMMI Analysis
Authors: Setiawan Indra , Dulbari Dulbari , Kartahadimaja Jainudin
Published: October 2024

Rice is the main food crop for most of the world's population. This research aims to obtain information on the influence of genotype interactions with the environment on potential grain yield characteristics and to obtain genotypes that have stability and adaptability to suboptimal environments. The research was carried out in March–July 2023 at Polinela Organic Farm. The experiment used a completely randomized group design (RKTS). Observations were made on the grain yield of 12 rice genotypes grown in three different environments. Statistical analysis using PBSTAT-GE software. There are three genotypes that have good stability based on eight stability analyses, namely Sertani 13 (G5), Inpari 30 (G12), and Trisakti (G6). Sertani 13 (G5) and Inpari 24 (G2) are genotypes with extensive adaptation. Genotypes based on specific environments are Baroma (G8), PTP 01 (G3), and Inpara 8 (G11), which adapt well to organic environments. Sertani 13 (G5) is adaptive to non-organic environments, and Mentik Susu (G4) is adaptive to aquaponic environments. The highest average production obtained based on the environment is non-organic, with an average yield of 5.95 tons/ha. Baroma (G8) is the genotype with the highest average, namely 6.85 tons/ha.
Determine The Effectiveness Of Balance In The Gut Microbiome And Some Blood Parameters In Obese Donors In Iraq
Authors: Abdulrahman Mahfoodh Khaleel  , Karkaz Mohamed Thalij
Published: October 2024

The current study aimed to evaluate the relationship between intestinal bacteria and some blood parameters in some cases of obesity in Iraq. The study included 60 samples. Their ages ranged from both sexes (20-64) years (40) samples of people suffering from obesity (Obesity Group) after confirming by measuring weight and height and extracting the value of the Body Mass Index (BMI) and (20) samples of people with ideal weight as a control group (Control Group). The study found that obese donors had decreased values of the parameters of mean red blood cell volume, packed red blood cell volume, hemoglobin, and red blood cells, while   obese donors had increased values of platelets, white blood cells, neutrophils, and lymphocytes. The results showed that obese donors had increased values of alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase.It was also noted through the results that there was an increase in the number of bacteria in the stool of obese people compared to the control group.
The Impact of Agricultural Land Use on Some Chemical Properties of Desert Soils in the Holy Karbala Governorate
Authors: Mohammed Abbood Bander  , Ayad Kadhim Ali
Published: October 2024

This study investigates the impact of agricultural land use on the chemical properties of desert soils in the Holy Karbala Governorate, Iraq. Despite the extensive use of desert soils for agriculture, little is known about how these practices affect soil chemistry in this region, creating a critical knowledge gap. The research employed a comparative analysis between cultivated and uncultivated lands across six pedons, analyzing key soil parameters such as pH, electrical conductivity, organic matter, and nutrient content. The findings reveal significant alterations in soil chemistry due to agricultural activities, including decreased soil pH and electrical conductivity, increased organic matter and cation exchange capacity, and variable nutrient content. These results underscore the need for sustainable land management practices to maintain soil health and productivity, which is vital for long-term agricultural success in arid environments.
Description of the Composition of Mixed and Pure Stand of Atrush Forest in Northern Iraq
Authors: Rashid Faiza Ali , Al-Allaf Mohammed Younis
Published: October 2024

Describing the trees of mixed and pure forests is of great importance to determine the various products and services they provide, so (12) samples were taken from each of the three densities, which were selected randomly, thus the total samples taken for the study amounted to (36) samples with a radius of (30) m. It was noted that there are (11) types of trees present in the study area (Atrush) and they vary in numbers the two dominant types are (Brutian pine and oak in its three types). Brutian pine was present in high proportions in samples (1, 4, 6, 33) and did not appear in other samples while it appeared in the sample (35) in a tiny proportion. As for the oak Quercus aegilops, it is dominant in most of the samples followed by Quercus infectoria while Quercus libani appeared in only one sample. As for the Crataegus azarolus, it spread in several locations and low proportions (0.47-25.25). As for the rest of the species, they appeared in very small proportions and limited samples. It was also found that there are different age stages for the pine as in sample (1), while the rest of the samples are mixed from pine and oak for samples (4, 6, 33). This indicates the modernity of these trees and the ability of the site and species to regenerate naturally. While we find that sample no. (35) contains different age numbers of oaks, which is the most widespread and is in the form of scattered and distributed branches, while pine trees are spread in small proportions and are in different age stages. As for the remaining samples, we find them to be pure oak trees.
Exterior Indicators Of The Orenburg Breed Little Goats Dependence On Sexual Differentiation During The Lactation Period Of Postembryonal Development
Authors: Djambilov Bekzod Khamitovich  , Yunusov Khudoynazar Beknazarovich  , Ibragimov Bakhodir Bakhtiyorovich
Published: October 2024

This article examines the exterior characteristics of little goats obtained from the first lambing of white Orenburg goats delivered to Nurata district from Orenburg region of the Russian Federation. In the course of the study, it was established how the exterior indicators of little goats change in the suckling period of postembryonic development depending on sexual differentiation.
Extending the Shelf Life of French Fries with Edible Bioactive Coatings from Potato Peels
Authors: Alasady Haneen Abdulamir , Khaleefah Luay S. , Shawkat Sadeq Muneer
Published: October 2024

This study explored the potential of potato peel-derived edible coatings to extend the shelf life of French fries. Potato peels, a food industry byproduct, were utilized as a sustainable source of bioactive compounds. The dried peel composition was analyzed, and an ethanolic extract was prepared. Edible coatings were formulated using this extract, glycerol as a plasticizer, and water as a solvent. French fry samples were coated and stored at 4°C and 50% relative humidity for 18 hours. Peroxide values were monitored during a 9-day refrigerated storage period. Results showed that coated samples had lower peroxide values (13.7 meq/1000g) compared to uncoated controls (17.5 meq/1000g), suggesting the coatings effectively delayed oxidative deterioration. This study demonstrates the potential of potato peel-derived coatings in extending the shelf life of fried food products.
Optimization of the Adjustable Screw Dosing Parameters of a Grain Seeder Designed for Agricultural Dryland
Authors: Mirzayevich Khudayarov Berdirasul , Fayziyevich Khudayqulov Rustam
Published: October 2024

This study focuses on optimizing the parameters of a screw dosing system in grain seeders for dryland agriculture to improve seed sowing efficiency. While ensuring agronomic requirements for seed distribution remains a challenge, the study addresses this gap by conducting multi-factor experiments using the Hartley-3 design. The research examines the effects of funnel surface area, screw rotation speed, and aggregate movement speed on sowing performance. Results indicate that these factors significantly influence sowing rates and seed distribution. Optimal settings for screw rotation and funnel area were identified, which promote uniform seed distribution. These findings have important implications for enhancing agricultural efficiency in dryland farming.
The Detection of Bioactive Compounds in Hemp Seed Oil Using GC-MS Techniques
Authors: Al-Jabir Haider , Ibrahim Majid , Abdulla Abdulla
Published: October 2024

The study was conducted in the Laboratories of the College of Agriculture, University of Basrah, Iraq in 2023 to detect the bioactive compounds in hemp seed oil using GC-MS technology. The detection device by GC-MS showed 33 bioactive compounds in hemp seed oil. The results indicate that hemp seed oil contained 16 unsaturated fatty acids. It was found that the content of hemp seed oil was high in the two unsaturated fatty acids, Linoleic acid methyl ester and Oleic acid methyl ester. The peak area percentage of these two unsaturated fatty acids was about 44.15% and 37.45%, respectively. The two unsaturated fatty acids, Palmitic acid methyl ester, and Stearic acid methyl ester recorded a lower peak area percentage, reaching 10.05% and 5.98%, respectively. The other fatty acids detected in the hemp seed oil sample recorded very lower peak area percentage ranging within the range (0.003% - 0.730%). The unsaturated fatty acid α-Linolenic acid, methyl ester in hemp seed oil recorded the lowest peak area percentage of all the compounds detected by GC-MS, which was 0.003%. The data indicated the presence of six unsaturated fatty acids with high molecular weights, namely Erucic acid, 11-Eicosenoic acid, methyl ester, n-Pentacosanoic acid, n-Tricosanoic acid, n-Heneicosanoic acid, and Heptacosanoic acid. The results revealed that hemp seed oil contains Dioxaphetyl butyrate (0.03%), Naloxone (0.03%), Odorine (0.10%), and Pretazettine (0.01%) for medical and therapeutic uses. Hemp seed oil contains the two most important bioactive compounds of the phytosterols, namely Beta-Sitosterol and Campesterol (0.13% and 0.02%).
Key Competencies of a Project Manager When Managing A High-Risk Project
Authors: JĘDRUSIK Agnieszka
Published: October 2024

Competence is a key element in the effectiveness of any business and is the key to the success of an organization. A project manager is a person who should have the right personality traits and skills to lead a project from the initiation phase to the completion phase according to a certain standard that allows the achievement of the set goals. The main purpose of this article is to outline the key competencies that every project manager should possess. There is no clear definition of key competencies in project managers in three areas based on certain standards. For the study was selected a group of project managers from the automotive industry from a medium-sized company located in the Podkarpackie ( southern part of Poland). The article includes a theoretical part containing a description of key competencies in three areas and their analysis based on the study of a group of project managers from the automotive industry.
Reorganization of the Production Process from The Complete Knocked-Down Approach to Partial Knocked-Down Production Assembly Method, The Case Study
Authors: MAJKA Monika , KOWALSKI Arkadiusz
Published: October 2024

The purpose of this article is to present the complexity of the production process transformation and to describe effective methods supporting the reorganization. Implementation of new assembly methods parallel with maintaining production continuity requires proper planning of the production and logistics process and quality and resources management. This paper describes the techniques that allow the organization to re-design and implement the processes according to defined scope. It also focused on cross-functional team cooperation, which is one of the success factors in securing effective problem-solving and preparing the optimal solutions. The transformation process can be executed by many ideas and ways of working, which are mentioned in this article, that’s why it describes the importance of the background decision and prerequisites to set the direction. The multidimensional aspect of the presented topic indicates that knowledge of available tools and methods is not enough to perform the transformation without proper preparation and understanding of the strategy of the organization.
Project Management in The Times of Trust Crisis
Authors: JOKIEL Maja , JOKIEL Grzegorz , BOBKIER Robert , BABCZUK Arkadiusz
Published: October 2024

Trust is one of the most important factors in organizational development and human interactions. It is not given by definition but rather created through dynamic interactions between individuals and institutions. Therefore, it is essential to acknowledge the existence of varying levels of trust. The aim of this article is to identify tactics and strategies that enable effective and efficient project management during times of trust crisis. Project / Methodology / Approach The authors have conducted a literature review of project management in a trust deficit situation. They have also presented case studies that illustrate the use of necessary techniques in projects at risk due to low trust conditions among stakeholders. The result of this research is a list of required actions (tactics and strategies), that can be employed in projects at risk to enhance the working conditions of managers and contractors. The uniqueness of this research paper is highlighted by the scarcity of dedicated articles in general, in which other authors aim to assist practitioners in managing trust crisis in their projects. Most research papers focus on the positive role of trust in organizations and projects, or how to build this trust. Meanwhile, projects are also conducted in unfavorable conditions, including a crisis of confidence. Therefore, methods and supporting tools are essential to support project managers and contractors in handling different situations, which constitute the primary value of this research paper.
The Role of Leaders in Promoting Creativity in the Workplace: An Examination of Individual and Organizational Antecedents in Innovation Management
Authors: NEUENFELDT Eric , SULÍKOVÁ Rozália
Published: October 2024

This study explores the pivotal role leaders play in fostering creativity and innovation within organizations. As businesses face rapidly evolving markets and technological advancements, the ability to remain competitive hinges on leveraging creativity and innovation. The study aims to elucidate how leadership can cultivate an environment conducive to creative thinking and innovative practices. While previous research has underscored the importance of creativity and innovation, there is a gap in understanding the specific mechanisms through which leaders influence these elements at both individual and organizational levels. This study addresses this void by providing a comprehensive analysis of the antecedents of creativity influenced by leadership. The study employs a qualitative approach, synthesizing existing literature and theoretical frameworks to examine the multifaceted role of leaders in promoting creativity and innovation. Key factors such as leadership styles, communication, support mechanisms, and organizational culture are analyzed to determine their impact on creativity. The research draws from a broad range of academic sources to build a cohesive narrative on the subject. The study finds that leaders significantly impact both individual and organizational antecedents of creativity. By fostering a culture of openness, risk-taking, and continuous improvement, leaders can inspire creative thinking and innovative solutions. Effective leadership involves providing resources, encouraging collaboration, and establishing psychological safety. The findings highlight that organizations prioritizing leadership development can unlock their teams’ creative potential, driving innovation and maintaining a competitive edge in dynamic markets.
Measurement And Analysis of Lighting in A Selected Manufacturing Company
Authors: WOJTYTO Dorota , MICHALIK Joanna , BERSK Szymon , KRAKOWIAK Marlena
Published: October 2024

Work environment factors indirectly, or more often even directly, affect the quality and efficiency of work processes. These include physical, chemical, psychophysical factors, and often hazardous factors are also distinguished. This paper presents the results of research into the measurement and analysis of lighting, which is a physical hazard in the work environment. The work is a continuation of research on physical factors in a selected production plant. Previously, research was conducted on noise measurement, as well as risk assessment of other workplace hazards. The motive of the study was to analyse the correctness of the lighting used in the workplace at the selected workstation and measures to improve the employee’s working conditions in this respect. The subject literature, especially standards (primarily Polish) concerning lighting used in the workplace, clearly indicate how it should be applied and fully exhaust the theoretical scope of the work. However, it is important to determine whether the designed workstation meets these standards and whether, in reality—as theory dictates—they are sufficient to carry out work processes. In this paper, the scope of research included the measurement and analysis of lighting at the injection moulding machine operator’s workstation using specialized research equipment – a luxmeter. The control results enabled better organisation of the workstation in terms of ergonomics and occupational safety, including the reduction of accidents, and consequently better work efficiency of the employee, and in a broader sense, the improvement of processes in the company. Additionally, the research results could be used to develop solutions for other companies in the sector with a similar profile of activity and similar workstations.
Evolving Role of PMO in Contemporary Project Management
Authors: WĘGRECKA-CHUDZIK Kinga , JANKOWSKI Łukasz , DUDA Jerzy
Published: October 2024

The motive behind this study is to explore the evolving role of the Project Management Office (PMO) in contemporary project management, addressing the lack of comprehensive literature on PMO models and their impact on organizational performance. Despite existing studies on PMOs, there is a void in the literature concerning the detailed classification and effectiveness of various PMO models tailored to specific organizational needs. The methodology involves a comprehensive literature review and analysis of multiple PMO models, including Business Unit PMOs, Project-Specific PMOs, and Global PMOs. The study examines the functions, roles, and impact of PMOs in different organizational contexts. The findings highlight that organizations with well-established PMOs achieve higher project success rates, improved delivery, and better alignment with strategic goals. The analysis underscores the importance of aligning PMO functions with organizational culture, project complexity, and leadership support to maximize effectiveness. The study provides insights for organizations to select and implement the most suitable PMO structure, enhancing project management outcomes and overall organizational success.
Upaya Penyelesaian Malpraktek Medis dengan Menghadirkan PayungHukum Tindak Pidana Medis
Authors: Sulava Sururi Ramadhan
Published: October 2024

The development of health services and the demands of the community have an impact on changing the need forcompetence in primary health services which is one of the responsibilities of doctors. The emergence of variouscases involving patients with doctors in the legal realm then creates problems because it is very difficult todistinguish which is malpractice and which is negligence, accident, or failure by health workers. Until now,Indonesia does not yet have a nationally applicable medical professional standard. The absence of medicalprofessional standards is detrimental to the medical profession and society because professional standards fordoctors can be used as a tool to defend themselves for their medical actions, especially if medical practice harmspatients. This paper aims to analyze the importance of the presence of medical-legal protection as a guarantee ofthe protection of human rights for the community and medical personnel, especially doctors. The normativeresearch method uses a conceptual approach, a case approach, and a statutory approach. Many laws andregulations regulate malpractice but are unable to explain in detail the medical crime itself. So that a special lawshould be formed that explicitly regulates medical crimes so that the rules do not overlap and the resolution ofmedical cases can be resolved quickly and accurately.
Tinjauan Yuridis Carding Sebagai Kejahatan TransnasionalTerorganisir
Authors: Haris Haris kusuma wardana , Wahyu Hariadi  , Teguh Anindito
Published: October 2024

Carding is a part of cybercrime that appears from the development of information technology which is not onlyhave a positive impact but also the negative impact for the users. The number of carding’s cases proved that thiscrime is a big threat to society both nationally and internationally. This research will discuss whether cardingcan be categorized as a transnational organized crime and how the government’s efforts in undertaking cardingthrough penal and non-penal policy. The methodology used in this law research is a normative juridical research.The specification of the research used in this law research is descriptive analytical. The methodology used incollecting data by the writer is researching the literature or the secondary data, then analyzed it using analyticalqualitative methods. Based on the result of this research can be concluded that neither the Budapest Conventionon Cybercrime nor the Law of the Republic of Indonesia Number 11 of 2008 Concerning Electronic Informationand Transactions did not directly mention the carding as a crime. According to the elements of carding, it can becategorized as a cybercrime which can be done transnationally.
3. NGHIÊN CỨU TỶ LỆ, THÀNH PHẦN LOÀI NẤM NÔNG GÂY BỆNH Ở BÀN CHÂN BẰNG KỸ THUẬT HÌNH THÁI VÀ SINH HỌC PHÂN TỬ Ở TIỂU THƯƠNG TRÊN ĐỊA BÀN TỈNH NGHỆ AN
Authors: Linh Dương Thị Khánh , Anh Lê Trần , Hải Tăng Xuân
Published: October 2024

Đề tài: Nghiên cứu tỷ lệ, thành phần loài nấm nông gây bệnh ở bàn chân bằng kỹ thuật hình tháivà sinh học phân tử nhằm mục tiêu: Xác định tỷ lệ, thành phần loài nấm men, nấm sợi và vị trí phân loại nấm gây bệnh trong cây phả hệ.
Phương pháp: Bằng phương pháp nghiên cứu mô tả thực nghiệm tại la bô, với các kỹ thuật nuôi cấy nấm trong môi trường Saboraud Chromagar với độ pH < 5,5 và có kháng sinh. Xác định tỷ lệ, thành phần loài dựa vào khóa định loài, sinh học phân tử và giải trình tự gen.
Kết quả: Trong 126 mẫu nấm, tỷ lệ nấm men là 94 mẫu (74,6%) và nấm sợi chiếm 25,4%(32/126). Bằng phương pháp định danh bằng hình thái, PCR-RFLP và giải trình tự, nghiên cứu chúng tôi phát hiện 11 giống với 24 loài. Tác nhân nấm men gây bệnh nhiều nhất 74,7%(94/126), trong đó Candida albicans chiếm tỷ lệ cao nhất 61,7%(58/94). Tác nhân nấm sợi gây bệnh chiếm 25,4%(32/126), trong đó tỷ lệ cao nhất là Asfergilus flavus 46%(18/32). Một số loài gây bệnh ít gặp cũng được phát hiện là Talaromyces pinophilus, Curvularia lunata, Penicillium polonicum, Trigonopsis variabilis...
Kết luận: Đã xác định được 11 giống, 24 loài nấm nông gây bệnh ở bàn chân
5. XÁC ĐỊNH THÀNH PHẦN NẤM MIỆNG Ở BỆNH NHÂN HIV/AIDS TẠI TRUNG TÂM NHIỆT ĐỚI BỆNH VIỆN HỮU NGHỊ ĐA KHOA NGHỆ AN (2020 -2022)
Authors: Thắm Ngũ Thị , Du Vũ Văn , Trâm Quế Anh
Published: October 2024

Mục tiêu: Xác định tỷ lệ, thành phần loài nấm miệng bằng hình thái và sinh học phân tử
Phương pháp: Đề tài được thiết kế bằng phương pháp nghiên cứu mô tả thực nghiệm tại la bô; Các kỹ thuật được sử dụng trong nghiên cứu gồm: Kỹ thuật nuôi cấy, tăng sinh mẫu nấm dương tính trên môi trường Sabouraud Dextrose Agar; Thử nghiệm huyết thanh; Kỹ thuật nuôi cấy, phân loại bằng môi trường thạch CHROMagar™ Candida (do hãng CHROMagar, Pháp sản xuất); Xác định loài nấm bằng kỹ thuật PCR – RFLP với gen mồi là ITS-1, ITS -4 có sử dụng emzym phân cắt hạn chế MSP-1 và Giải trình tự gen xác định loài nấm.
Kết quả: Trong 55 chủng phân lập được, kết quả định danh bằng hình thái học: Chủng C. albicans chiếm tỷ lệ cao nhất 65,5% (36/55), tiếp đến là C. tropicalis 12,7%, có tới 10,9%(6/55) chủng Candida spp không xác định được bằng phương pháp hình thái. Kết quả xác định loài bằng phương pháp giải trình tự gen Kết quả định danh bằng giải trình tự là kết quả cuối cùng. Kết quả đã xácđịnh 10 loài nấm, trong đó: C. albicans chiếm tỷ lệ cao nhất 60% (33/55); C. tropicalis 20%(11/55); Các loài khác ít gặp hơn như C. dubliniensis, C. glabrata, C. krusei, C. parapsilosis, C. metapsilosis, Meyerozyma caribbica đều chiếm 1,8%(1/55); C. mesorugosa chiếm 3,6%(2/55). Nghiên cứu này bằng kỹ thuật giải trình tự gen phát hiện được một số  loài gây bệnh hiếm gặp như Kodamaea ohmeri 3,6%(2/55), Meyerozyma caribbica 1,8%(1/55).
Kết luận: C. albicans chiếm tỷ lệ cao nhất khi xác định loài bằng hình thái học và sinh học phân tử 65,5%(36/55) và 60% (33/55), đã phát hiện một số loài hiếm gặp Kodamaea ohmeri 3,6%(2/55), Meyerozyma caribbica 1,8%(1/55).
10. SỰ PHÂN BỐ CÁC CHỈ ĐIỂM CHỈ ĐIỂM GEN LIÊN QUAN KHÁNG THUỐC CỦA Plasmodium falciparum TẠI BỐN TỈNH TÂY NGUYÊN (2019-2021)
Authors: Trinh Nguyễn Thị Minh , Diệu Lê Thị Hạnh , Hạnh Nguyễn Thị Liên , Hương Nguyễn Thu , Xã Nguyễn Xuân , Quang Huỳnh Hồng
Published: October 2024

Mục tiêu: Xác định các chỉ điểm phân tử liên quan kháng thuốc trên quần thể P. falciparum tại bốn tỉnh Tây Nguyên
Phương pháp nghiên cứu: DNA tổng số sau khi được tách chiết được sử dụng cho các ky thuật Nested-PCR để xác định 4 loài ký sinh trùng sốt rét; PCR để thu nhận các gen K13, Exonuclease và Pfcrt; giải trình tự các đoạn gen này bằng phương pháp Sanger; và sử dụng realtime-PCR để xác định các biến thể gen plasmepsin2 và Pfmdr1.
Kết quả: Nghiên cứu phát hiện tỷ lệ cao đột biến C580Y trong P. falciparum liên quan kháng artemisinin, cùng đột biến E415G trên gen Exonuclease và biến thể plasmepsin2 liên quan kháng piperaquin. Các đột biến Pfcrt như K76T, A220S (liên quan đến kháng chloroquine), F145I (liên quan đến kháng piperaquin), và biến thể Pfmdr1 (liên quan đến kháng mefloquine) cũng được ghi nhận.
Kết luận: Nghiên cứu đã xác định được các đột biến gen K13 liên quan đến kháng artemisinin, đột biến E415G trên gen Exonuclease liên quan đến kháng piperaquin, các đột biến trên gen Pfcrt liên quan đến kháng chloroquine, cùng với các biến thể plasmepsin2 và Pfmdr1 liên quan đến kháng piperaquin và mefloquine
12. ĐỊNH LOÀI PHÂN TỬ VÀ QUAN HỆ PHẢ HỆ CỦA NGOẠI KÝ SINH TRÙNG TRÊN BỆNH NHÂN VIÊM DA DO DEMODEX SPP. DỰA TRÊN 16S rDNA TY THỂ
Authors: Vinh Nguyễn Ngọc , Dũng Đỗ Trung , Quang Huỳnh Hồng , Trinh Nguyễn Thị Minh , Quyên Nguyễn Thị Thanh , Hạnh Nguyễn Thị Liên , Chính Nguyễn Đức
Published: October 2024

Mục tiêu: Xác định thành phần loài và quan hệ phả hệ Demodex spp. bằng sinh học phân tử.
Đối tượng và Phương pháp nghiên cứu: Tách chiết DNA từ các phân lập Demodex trên các bệnh nhân viêm da và khuếch đại PCR gen ty thể (mt) 16S rDNA. Sản phẩm PCR khuếch đại được tinh khiết và định loài. Sản phẩm mt16s rDNA đã khuếch đại được giải trình tự và so sánh với cơ sở dữ liệu BLAST trên ngân hàng gen NCBI để so sánh góc độ phân tử.
Kết quả: Tất cả 12 mẫu Demodex spp. đều thuộc loài D. folliculorum. Cây phả hệ di truyền được dựng dựa trên trình tự mt16s rDNA cho thấy D. folliculorum quan hệ gần hơn D. brevis. Tất cả phân lập thuộc D. folliculorum và giải trình tự một phần 16S rDNA ty thể có thể ứng dụng phân tích quan hệ phả hệ di truyền, nhưng không xác định nội loài.
Kết luận:Tất cả phân lập thuộc loài D. folliculorum và giải trình tự một phần (mt) 16S rDNA có thể phân tích mối quan hệ phả hệ ở mức độ phân tử giống loài.