bluuebunny/crossref_metadata_2025 huggingface dataset:
Romanian election newssheets in Banat and Transylvania before 1918
Authors: Popovici Vlad , Iudean Ovidiu Emil
Published: March 2022

The study analyses three publications that appeared in 1909 and 1910 and had a purely electoral nature: Oraviţa, Alegătorul (the Voter) and Sus inimile (Raise Your Hearts). These are the only Romanian election newssheets prior to the year 1918 that were preserved from Transylvania and Banat, being little known and referred to in historiography. the study presents the publications’ content, their role within the moment’s electoral campaign and the relationship between the information they offer and the one provided by other sources from the same period. The conclusions emphasise the important role played by these newssheets in understanding the electoral process at the beginning of the 20th century, but also their obvious limitations and especially the caution with which one must use the information they offer, as it is clearly influenced by their’ propagandistic and mobilising character.
Identitate și alteritate etnică și confesională in spatial arădean interbelic / Ethnic and Confessional Identity in Arad between World Wars
Authors: Boia Stelean-Ioan
Published: March 2022

After the First World War, the minorities were represented in Arad / Arad County by: Hungarians, Jews, Germans, Serbs, Croats, Czechs, Roma. The Romanian authorities faced numerous situations in which ethnic minorities opted for the citizenship of another state (the Hungarians) but refused to leave the country. The Romanian authorities had to organize their repatriation on several occasions. There was also the refusal of certain socio-professional categories (civil servants) to take the oath of loyalty to the Romanian state, to acquire Romanian language, to observe the national holidays and insignia. The local authorities’ reaction was in all cases moderate.The analysis of the demographic and socio-professional structure in Arad County allowed us to conclude on the existing relations between the majority and the minority, starting from the fact that the minorities constituted the majority of the population in the city of Arad (68,18% in 1925) and the Romanians the minority. In the rural settlements, the relations between the majority and the minority were changed, the Romanians having the highest weight.Throughout the interwar period, Arad represented a pattern of interethnic and interconfessional tolerance.
Iugoslavii și Bărăganul (1955) / The Yougoslaves and the Baragan Question (1955)
Authors: Milin Andrei , Milin Mirodrag
Published: March 2022

The death of the Soviet dictator Stalin breng to end the extreme tension among the countries of Eastern Communist Block and the Tito`s Yougoslavia. After the visit of new soviet lieder Hrusciov to Belgrade, slowly followed new steps toward a normalization of relations. The Yougoslav diplomacy started acting in Bucharest too, beginning with summer and autumn of 1955, in order to bring to end the deportation (of living in border area with Yugoslavia banatians) in Baragan plain and turn them home. The authors give a presentation of some relevant papers from Yugoslav diplomatic archives, revealing the pourparles taken place with Romanian communist rulers, in order to bring to a positive resolution the question of Baragan deportation.
The end of the roman habitation at Buridava (Stolniceni, Vâlcea county)
Authors: Purece Silviu I.
Published: March 2022

# e fi ve archaeological levels identifi ed in the Roman baths complex area at Stolniceni, dated in the period of the existence of Dacia Province, were chronologically dated as following: the 1st level: Trajan- the fi rst part of Antoninus Pius’rule, the 2nd level: the last part of Antoninus Pius’rule up to Commodus’rule, the 3rd level: the Commodus – Caracalla period, the 4th level: the Caracalla – Philippus Arabs period and the 5th level: the Philippus Arabs-Aurelian period. # e end of these fi ve levels mentioned above was brought about by fi re and destruction, the most powerful ones were characteristic to the 3rd and 4th levels. Even if the archaeological information is scarce, we believe that we can rely on the supposition that some phenomena that were identifi ed in the thermae area might have had a great impact on the whole settlement. # e diff erence between accidental destructions and intentional destructions can be established due to a vast array of information obtained not only form the site in question but also from a larger area. # us, we consider that this approach should rely entirely on the historical information obtained as a result of a thorough analysis of the hoards horizon. Every hoards horizons represented in the region are associated with one destruction moment from the Roman baths, with one exception the horizon from the year 260. # is situation determine us to reevaluate the chronological situation and to establish that is very possible to place the end of the Roman Buridava not in the time of Aurelian but at the beginning of Gallienus reign as sole emperor.
Politică şi administraţie în Districtul Caransebeş (sec.XIV-XV) / Politics and administration in the Caransebes District (XIV-XVth centuries)
Authors: Iusztin Zoltán
Published: March 2022

# e literature did not propose yet a certain hypotesis about the administrativ incorporation of this district from the Timiș Cerna Pass. # e documentary sources were incomended whit this problem, but, infortunely, were no able to off ere an exact and uniform localization, in the case of the valachian district. # ereby, some documents from de begining of the XV century place de districts of Mehadia and Caransebes, within the Timis County. Obviosly those prouves would make possible to sustain that the Pass, in the totality would be included into de Timis County, who should cover the region until the Danube. However, the posterior sources certifi cate that the district was placed under the authority of the Ban of Severin and, then the controversy about it’s administrativ situation might restart. Generally, the District of Caransebeș was included into the Timiș County in vacancies of the head the Banat of Severin. We don’t question those facts, but we stress that in such a moment the fortress of the district belong to the count like honorary fee, and that doesn’t supouse the inclusion of the district in the county’s borders. # e documentary sources, idintifi es, briefl y, that the same district belongs to the sub Banatu Zewreniensis. Our hypotesis, whereby we argue that the district of Caransebeș constitue an administrativ entity sui generis, is based on the famous privilege from 1457 and on the activity of the cnezial and nobiliar institutions. From that moment in the district, functioned beside the nobiliar and cnezial assamblies, one judex nobiles. # ose realities constitue the assential prouves in the confi rmation of the existence for all the administrative entities. In fact, the district has insititions that assure his own economic and judicial administration. And also, in the interior of certain district it’s impossible to found institution belonging to anther administrativ entity. Obviosly, regarding the political authorithy, this was assured, either by the Timis count, or by the Ban of Severin. # e last one, whit the vicebans presided or assistes more than a thirt of the total of the cnezial or nobiliar assamblies in the district of Caransebes.
Despre marile teme religioase din cultura Vinča / About the Great Religious Themes of Vinča Culture
Authors: Lazarovici Gheorghe Corneliu , Lazarovici Magda Cornelia
Published: March 2022

In this study we made a quite large presentation of some important religious themes of Vinča culture, one the most important civilization of Neolithic period. Based on di!erent discoveries, on literature, as well as on our own experience we have noticed that many of the main religious themes are intercorrelated.So, we have discussed the problem of sanctuaries and cultic inventory, focus on Zorlenţu Mare, Balta Sărată, as well as on Liubcova discoveries.It was discussed and the fragmentation of idols, ritual breaking of sacred e"gies, how it is right to be named, idols or gurines. We referred to the types of masks (human or animal) illustrated by Vinča plastic art. In connection with masks we have approached other problems, such as sacred liquid, symbols of power and social distinctions (cross band, belt, diagonal band etc.).Another important theme is related with birth and sexual organs (phallus, vulva), some artifacts giving us opportunity to present analogies or similar depicting manner.Vinča plastic art also re#ect the theme man-bird, bird, #ight (idol or amulets of Zorlenţ type, with anthropomorphic and ornithomorphic attributes). Dance and music are part of sacred, expressed through alto relief manner of rendering feminine characters on Zorlenţu Mare pots; ocarina discovered at Liubcova can be considered as one of the earliest musical instruments in the area.We did not avoided elements related with magic, but we have underlined that is quite di"cult to make di!erence between the white and the black magic practices, based on artifacts from Zorlenţu Mare, Gornea, or Balta Sărată.Another topic was related to the symbols and signs discovered on several objects related with sacred: idols, pots, altars, table/altars, candles, sacred house, tablets, plates, discs, buttons, and breads. Analogies and similarly discoveries have been presented with reference to our database, Scrierea (Word), as well as the Danube script. Analyzes of di!erent artifacts has underline other important themes, such as sacred marriage, oranta (worship position), throne etc.Most of the religious themes of Vinča culture as in other civilizations are related with events of humans and cycles of nature, sacred and profane being in an inextricably dependence.
Das Banat und das Risorgimento: der Sardinische Krieg 1859 und seine Auswirkungen im Banat / Banat and Risorgimento: Second Italian War of Independence and its Influence in Banat
Authors: Krčmar Filip
Published: March 2022

Based on the archival holdings of Archive of Vojvodina (F. 23 Landesverwaltung der Wojwodschaft Serbien und des Temesvarer Banat 1849–1861), as well as on the writing of contemporary press (Wiener Zeitung, Temesvarer Zeitung, Gross-Becskereker Wochenblatt, Werschetzer Gebirgsbote, Lugoser Anzeiger), the paper discusses ways and means in which the region of Banat was influenced by the Second Italian War of Independence of 1859. Following important issues have been addressed: gradual preparation of domicile population for the war by the government run press; mobilization and usage of financial, material and human resources of Banat; war participation of Banat based regiments, as well as formation of voluntary battalions; war losses and decorations; and last but not the least – an utmost interesting question of the attitude of Banatians towards the war. For little less than a decade they have been subjected to rather unpopular and much hated neo-absolutistic policy of the Bach’s regime, that in war times demanded an unconditional allegiance and self-sacrifice. On the other hand, regardless of their nationality, they looked with sympathies at the enemy’s freedom and independence struggle. In practice, such attitude led to an enormous, although publicly hardly visible dissatisfaction with the war, in quite opposition to the patriotic image imposed and carefully nurtured by the press. Beside to formation of Italy in 1861, the unfavorable outcome of the war for Austria subsequently led to inner instability and dissolution of the Crown Province Voivodeship Serbia and Banat of Temesvar in same year. Ethnically mixed population almost unanimously greeted such turn of events.
Aspecte privind locuirea otomană in zona cetății Noviodunum / Aspects concerning Ottoman Period Habitat in the Area of Noviodunum Fortress
Authors: Stănică Aurel-Daniel , Dinu Niculina
Published: March 2022

Archaeological site Noviodunum is on the right bank of Danube, on a promontory (Eski–kale) near the most important shoal, in the right of 65 sea miles and about 3 km east of the city center Isaccea (jud. Tulcea). The ancient Noviodunum was identified until the end of XIXth century but the first archaeological researches started after the middle of XXth century when there are surveys on the east, south and west side. Through its geographical location Noviodunum had an important strategic and economic role in the Roman, Byzantine and Middle Byzantine time, the settlement here ceasing at the end of the XIVth century to continue on the territory of modern Isaccea city. Probably in the XVIIth century in the central area of Noviodunum fortress, the Ottomans set up a fortification, tabya (palanca) and in the XVIIIth century they raised a stellate fort in the north–east and a secondary fortification in the northwest. The existence of Oriental ceramics, Ottoman or the Far East in archaeological contexts or accidental findings show the importance of the area in the Ottoman period even after XVIth century, here there is a massive destruction. Ottoman ceramics discovered generally dated in the XVIIIth century being produced by the workshops of Kutahya and the prevailing form, cup, shows that coffee ritual was widely spread not only among soldiers but also the local population.
EIN RILLENHAMMER MIT GERITZTEN Ein Rillenhammer mit Geritzten Darstellungen aus Şoldăneşti, nordwestliches Schwarzmeergebiet.AUS ȘOLDÃNEȘTI, NORDWESTLICHES SCHWARZMEERGEBIET
Authors: Kašuba Maja
Published: March 2022

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Un destin feminin în Banatul sfârşitului de secol XVI: Barbara Moise / The Destiny of a Lady from Banat at the End of the XVI Century – Barbara Moise
Authors: Magina Livia
Published: March 2022

This study aims to bring to historiographical light one of the few cases where the documents present a storyin which the main character is a woman, namely Barbara Moise.She comes from a noble family in Caransebeș, the Moise family, which appears in documents from thesixteenth century. She is destined to have her three marriages end in a relatively short period of time, withoutchildren, and in each case the husband dies and the lady remains widow. Her first husband, Mihail Mâtnic,is a member of a traditional family, a rich family, but his death brings a lot of debts for Barbara. The secondalliance, with Ioan Găman, the member of another big family from Caransebeș, is a deja-vu. Ioan borrowsmoney from his wife and gives her some of his possessions. After Ioan’s death, his family sought to reclaimthe possessions. The third, and the last known marriage, was to Petru Krichoway, also from Caransebeș.Unfortunately, the end, happy or unhappy, is unknown.It should be noted that her case was not unique, on the contrary, it was but one among others, probably many,at that time. The annexes demonstrate the power of the man’s words, and the fact that the status of women wasnot enviable.
The Bronze Axes Hoard of Fântânele-Rus (Rus Commune, Sălaj County, Romania)
Authors: Bejinariu Ioan , Sana Daniel V.
Published: March 2022

The study concerns an unpublished bronze hoard discovered fortuitous in the `70`s in a village (Fântânele –Rus) in north-eastern part of Sălaj county, on Someș valley. The hoard consist, at least in two bronze axes with disc and spike. They analyzed several aspects of the bronze hoarding phenomenon from the so-called „Someș Corridor.” Unfortunately, the archaeological research of contemporary settlements of these hoards remain only a dream for the future.
Cercetări arheologice preventive pe traseul Autostrăzii Lugoj-Deva, lot 2. Descoperirile culturii Coțofeni de la Nemeșești, comuna Margina, județul Timiș / The Preventive Archaeological Research of Lugoj-Deva Motorway Project, 2nd Section. The Coțofeni Culture Discoveries from Nemeșești, Margina Commune, Timiș County
Authors: Bejinariu Ioan , Pop Horea
Published: March 2022

This paper presents recent discoveries of the Coţofeni culture from the northeast Timiş county, from Nemeşeşti, Margina commune (Pl. I/1). The investigations were preventive and took place on the Lugoj – Deva Motorway project. A peripheral area of a Coţofeni settlement was investigated and 19 features (different pits and a dwelling) were discovered. The archaeological inventory consist mainly in very fragmented ceramics and flint cores or chips. Based on the ceramic inventory the Coțofeni features from Nemeșești can be assigned to the Coțofeni 3rd phase.
O brǎţarǎ din bronz descoperitǎ la Plosca (jud. Dolj) / A Bronze Bracelet Discoverd at Plosca (Dolj County)
Authors: Motzoi-Chicideanu Ion , Monica Șandor-Chicideanu Monica
Published: March 2022

In summer 2003 a bronze bracelet has been found by fortune not far from the place of the excavation in a Bronze Age cemetery. & e place of discovery is on the southern edge of the Lake Bistreţ, village Plosca, Dolj County (Fig. 1). It is possible that the bracelet could be a piece from a bronze hoard lost today. Broken from old time, the bracelet is decorated by incisions (Fig. 2). From the morphological point of view the most important element is the triangular section, so it could say that the piece belong to a large category defi ned on this element. Such bracelets are typical for the hoards belonging to the so called Cincu-Suseni type, from the beginning of the Early Iron Age (Hallstatt A) especially in Transylvania (Fig. 3).In the area of the lake Bistreţ were searched some objects with fl utted pottery belonging to the same period, to the so called Vârtop culture. It is very possible that the bracelet from Plosca belong to this culture reached the southern Oltenia as a result of the long distance exchange.
The Relations of the Cruceni-Belegiš Culture with the Zuto Brdo–Gârla Mare Culture
Authors: Szentmiklosi Alexandru
Published: March 2022

The archaeological investigations concerning the Bronze Age withinthe area of the Middle and Lower Danube demonstrated the existence of anethnical-cultural complex characterized through a series of commonelements that suggest the relationship among the different ethnical-culturalmanifestations within this area. The main common denominator is theceramics whose ornamentation consists in motifs executed throughprinting, incision, notches and successive stitches. The motifs were inlayedwith white substance. The funerary common ritual, respectively thecremation, the anthropomorphical statues, the bird-shaped representationsand the clay little bells suggest similar religious beliefs.
Analisis Prilaku/Stabilitas Pendingin Thermoelektrik Yang Di Tenagai Matahari
Authors: Widodo Dwi Alia , Rizal Teuku Azuar , Abdullah Nasruddin
Published: March 2022

Solar power is an environmentally friendly renewable energy source. Solar power is utilized by solar power plants to generate electricity. The electrical energy produced is light energy which is converted by solar cells. A collection of solar cells arranged in such a way as to produce solar panels. The electrical energy produced will be stored in a medium called a battery. In the storage and use of this electrical energy, care must be taken to avoid overcharging/overcharging and over-using/over-discharging. Therefore, a battery charge controller is used which will regulate charging or energy consumption, besides that it also functions as a protection device. For the use of AC loads, an inverter is used to adjust the output voltage to VAC.
Management of Frugal Innovation Projects: Research Approach and Perspectives
Authors: Mignenan Victor
Published: March 2022

Frugal innovation is a key lever to meet the needs of low-income consumers. Its real challenge is to introduce something new (innovate) to the market while minimizing (frugal) resource constraints. The phenomenon of innovation frugality has traditionally been studied in relation to emerging and developing countries. Today, several studies point out that frugal innovation is also practiced in advanced economies. Although the studies are of great interest to many, they have not been able to identify the concept or map the approach. Therefore, we do not know (i) how the frugal innovation approach developed during the period from 2010 to 2018 (ii) What is the mapping of the phenomenon of frugal innovation? (iii) What are the relevant areas of research during this period? And finally (iv) what are the areas and opportunities for future research? To answer these questions, we first conducted a systematic review of the literature by analyzing 106 articles published from 2010 to 2018. Second, we conducted an interview with 61 respondents made up of researchers, experts, and practitioners to validate the main research gaps identified and identify themes relevant for future research. The results of the research show that researchers affiliated with universities and institutes in the UK, India and both countries are in the majority and have been instrumental in research on frugal innovation management. Similarly, it appears from the above that several products resulting from frugal innovation come from India and China. In addition, our results indicate that articles on frugal innovation are published in a wide range of disciplines and journals. However, researchers, experts and practitioners perceive the concept of frugal innovation in different ways. As a result, studies on frugal innovation focus on sectors such as health, electricity, electronics, transport, finance, ICT, and energy. On the other hand, despite their great importance, the agriculture and education sectors are little explored. The results of the research call on actors to further explore the housing, agriculture, education, and energy sectors in emerging and developing countries.
Hybrid Quaternions of Leonardo
Authors: Mangueira M. C. S. , Alves F. R. V. , Catarino P. M. M. C.
Published: March 2022

In this article, we intend to investigate the Leonardo sequence presenting the hybrid Leonardo quaternions. To explore Hybrid Quaternions of Leonardo, the priori, sequence of Leonardo,quaternions and hybrid numbers were presented. Soon after, its recurrence, characteristic equation, its relation with the Fibonacci quaternions, generating function, Binet’s formula, as well as its extension to non-positive integer indices were developed. Finally, identities involving Leonardo’s hybrid quaternions are presented.
Strong Stability Preserving Runge-Kutta Methods Applied to Water Hammer Problem
Authors: Santiago D. F. G. , Antunis A. F. , Trindade D. R. , Brandão W. J. S.
Published: March 2022

The characteristic method of lines is the most used numerical method applied to the water hammer problem. It transforms a system of partial differential equations involving the independent variables time and space in two ordinary differential equations along the characteristics curves and then solve it numerically. This approach, although showing great stability and quick execution time, creates ∆x-∆t dependency to properly model the phenomenon. In this article we test a different approach, using the method of lines in the usual form, without the characteristics curves and then applying strong stability preserving Runge-Kutta Methods aiming to get stability with greater ∆t.
Dispersión accionaria y desempeño de los bancos argentinos
Authors: Dutto Martín , Narvaez Marcos , Carlevaro Emiliano , Jullier Juan
Published: March 2022

In this paper, we analyze the degree of ownership concentration as a determinant of performance in Argentine banks, measured through return on assets (ROA), return on equity (ROE), and Net Financial Income during the period from 2005 to 2017. Based on panel data analysis, we conclude that there is a negative relationship between ownership concentration and performance. This association is positive for banks with few owners. We argue that controlling owners take excessive risk in banks with lower levels of ownership concentration which results in low returns. Adversely, a less risk taking behavior increases at higher levels of concentration.
Reception date: April 20, 2020Acceptance date: October 9, 2021
Efficacy of Upper Limb Plyometric Training in a Badminton Player
Authors: Narang Simran , Phansopkar Pratik , Chitale Neha , Arora Sakshi P.
Published: March 2022

There are six basic moves, in badminton. The most every and efficient offensive badminton technique for the player to defeat the opponent is smashing among these moves. Shoulder strength is a muscle's ability to bury the resistant to execute a shoot. Ballistic Six training is given to enhance the efficacy of the throwing exercise and to strengthen the muscles of the rotator cuff with overhead throwing activity to prevent injury to the shoulder. Sitting medicine ball throw test was 335.28cm. Closed Kinetic Chain Upper Extremity Stability Test showed 21 touches. Plate tapping test is 17. 98sec.Training Program- Upper limb plyometric exercises were given. The exercise protocol was divided into three phases- warm up, plyometric exercises and cool down. The Protocol was followed for 6weeks and difference was seen in agility speed and strength. The Ballistic Six upper extremity plyometric training program involves a series of functional exercises performed at high volumes to simulate the movements, positions and forces involved with the overhead throwing motion. In order to take advantage of the stretch reflex, plyometric training was conducted in a ballistic, high-velocity manner to decrease the amortization phase of the stretch shortening cycle. Kim Yew Tiong and Chin Ngien Siong (2019) carried a study on 12-year-old badminton players to examine the effectiveness of Plyometric and Resistance Band Training on Badminton Overhead Clear through 6- week training and concluded that those 6 weeks of plyometric training was more effective in enhancing badminton overhead simple stroke efficiency. Keywords: Upper Limb, Plyometric training, Badminton player, Rehabilitation.
Design and characterization of daunorubicin loaded solid lipid nanosuspension
Authors: Babu N Dora
Published: March 2022

Objective the objective of the current review was to research the conceivable utilization of strong lipid nanosuspension (SLNs) as a medication conveyance strategy to support Daunorubicin (DNR) mind focusing on execution after intranasal (I. n.) organization. Techniques: 33 factorial plans were applied for advancement by utilizing lipid fixation, surfactant focus, and High-speed homogenizer (HSH) mixing time as reliant factors, and their impact was seen on particles size, Polydispersity record (PDI), and entanglement proficiency. Results with the organization of Compritol® 888 ATO (4.6 % w/v), tween 80 (1.9 % w/v), and HSH blending time, the enhanced equation DNR-SLNs arranged (10 min). Molecule size, PDI, zeta potential, capture effectiveness, percent in vitro discharge was viewed as 167.47±6.09 nm, 0.23±0.02, 24.1 mV, 75.3±2.79, and 89.35±3.27 percent in 24 h, individually, for streamlined detailing (V-O). No significant changes in molecule size, zeta potential, and ensnaring effectiveness were found in the security learns at 4±2 °C (fridge) and 25±2 °C/60±5% RH up to 3 mo. Conclusion following the administration of non-invasive nose-brain drugs, which is a promising therapeutic strategy, the positive results confirmed the current optimized formulation of DNR-loaded SLNs. Keywords: Solid lipid Nanosuspension, Homogenization and Ultrasonication, Characterization, Factorial design, Nose to brain delivery.
Assessment of galectin-3 in thyroid lesions expression through immuno-histochemical approach
Authors: Repana Sasidhar , Ramasamy Thiripurasundari , Lourdes Jacqueline , Velayudhan ShanmugaPriya
Published: March 2022

Papillary thyroid carcinoma (PTC) is the most prevalent kind of thyroid cancer and is distinguished by unique nuclear characteristics. The lesions may be diagnosed morphologically and histo pathologically in the majority of instances using standard Hemato xylin and Eosin stained sections. In some cases with the follicular pattern, it is challenging to make the decision between benign and malignant tumor. This diagnostic dilemma shows a major role in the management and prognosis of the patient. Hence the additional support is required to assess the lesion to diagnose the thyroid tumor. In this context this study is taken up to evaluate the usefulness of galectin-3 in the diagnosis of thyroid lesions either as a benign or malignant. The galectin 3 expression was examined in 20 benign follicular adenomas and in 20 malignant papillary carcinoma through observational study. On poly-l-lysine coated slides, 4 mm thick paraffin sections were examined by IHC using standard procedures. All the 20 cases of follicular adenoma showed negative staining for galectin3, whereas all papillary carcinoma in thyroid and its variants showed strong positivity 3+ in 18 cases and 2+ in 2 cases. The diagnosis of papillary carcinoma in thyroid and its variants is very sensitive and specific with galectin-3. Though diagnosis of conventional papillary carcinoma is not that difficult, dilemmas arise more often in follicular variant in which galectin 3 immunohistochemistry can be helpful. Galectin 3 can be used to differentiate benign and malignant tumors. Keywords: Galectin 3, papillary carcinoma, thyroid gland and follicular adenoma.
In-vitro evaluation of the thrombolytic and anti-inflammatory activity of capparis sepiaria root extracts
Authors: Baidya Moushumi Baidya , Sekhar Maji Himangshu , Bhatt Shvetank , Das Dibya
Published: March 2022

The dried roots of Capparis sepiaria was powdered and extracted successively in soxhlet assembly. The extracts acquired had been dried after which subjected to preliminary phytochemical screening. The in vitro thrombolytic and anti-inflammatory activities of total ethanolic and aqueous extracts for Capparis sepiaria roots were performed using thrombolytic and inhibition of protein denaturation assays respectively. The preliminary phytochemical screening carried out from successive solvent extracts of Capparis sepiaria has shown the presence of carbohydrates, fixed oil, fats, alkaloids, flavonoids, tannins and phytosterols. Total aqueous and ethanol extracts were tested for clot lysis and inhibition of protein denaturation showed significant thrombolytic and anti-inflammatory activity. The total aqueous extract has shown more potential as compared to the total ethanolic extract. It can be concluded that the Thrombolytic and Anti-inflammatory properties of the total ethanolic and aqueous extracts are due to the presence of the specific phytoconstituents present in the root extracts. Keywords: Capparis sepiaria, Thrombolytic, Anti-inflammatory activity, Root extracts and Phytochemical screening.
A mini review on centrifugal spinning technique for production of nanofibers and its applications in drug delivery
Authors: Satish Shirolkar , Priya Rodge
Published: March 2022

Nanofibers possess distinctive physicochemical and biological properties and have been utilized in a wide range of research and commercial applications. Electrospinning is a widely used technology for generating nanofibers, but due to its low production rate, it lacks scalability. Centrifugal spinning is a low-cost process for producing nanofibers that is simple, quick, and scalable. It has emerged as a potential technology for fabricating nanofibers with a variety of applications due to its extremely high production rate and multifaceted features. The centrifugal spinning process involves injecting the polymer solution or melt in a rotating spinneret. When the spinning head reaches a critical speed, the centrifugal force overcomes the surface tension of the spinning liquid, and a liquid jet ejects from the nozzle tip. The jet is then stretched further, resulting in solidified nanofibers on the collector. The technique is capable of producing 3D nanofiber scaffolds from various polymers for biomedical applications. This paper describes in details the centrifugal spinning process, its classification, principle and applications of the centrifugal spun nano/micro fibers in drug delivery and wound dressing. Keywords: Nanofibers, Centrifugal spinning, Solubility enhancement, drug delivery.
A stability indicating method development and validation of apixaban in pharmaceutical dosage form by using RP-HPLC and In-Vitro evaluation of apixaban suspension delivery through enteral feeding tubes
Authors: Rajput Rajendra Singh , Lariya Narendra
Published: March 2022

A simple, consistent and sensitive stability indicating reversed phase high performance liquid chromatography (RP-HPLC) method was developed for the determination of Apixaban in pharmaceutical dosage form by using Zorbax C18 (150 mm x 4.6 mm, 5μm particle size) with a mobile phase consisting of Ammonium Formate Buffer: Acetonitrile in a ratio of 65:35% v/v and successfully validated as per the international council for harmonization (ICH) guideline. The method was found to be simple, robust, precise, sensitive, accurate; specific and stress degradation studies were performed with acidic, alkaline, oxidative, thermal, humidity and photolytic stress conditions as per ICH guidelines. In separate in-vitro experiments, Apixaban suspension passed through feeding tubes to develop a clog-free suspension delivery method. Nasogastric tube (8-French [Fr]) and diluents (water, 5% dextrose in water) were tested. Recovery of Apixaban Suspension in water and 5% dextrose in water at “0 and 15” minutes incubation time were nearly 100% in 8-Fr nasogastric (NG) tubes. Keywords: Apixaban, Stress Degradation, Stability Indicating Assay Method, Nasogastric Tube.
A stability indicating method development and validation of esomeprazole in pharmaceutical dosage form by using RP-HPLC and In Vitro evaluation of nasogastric tube delivery of esomeprazole magnesium delayed-release capsules
Authors: Rajput Rajendra Singh , Lariya Narendra
Published: March 2022

A simple, selective and well-defined stability indicating method was developed for the quantitative estimation of esomeprazole in tablet dosage form using XBridge BEH Shield RP18 (4.6 x 250 mm), 5μm with phosphate buffer pH 7.3 and acetonitrile (740:260 %v/v) as a mobile phase and successfully validated as per the ICH guideline. The method was found to be specific, linear, accurate, rugged, and robust. Stress degradation studies were performed by exposing the esomeprazole magnesium delayed release capsules into acidic, alkaline, oxidative, thermal, humidity and photolytic stress conditions as per ICH guidelines. In separate in-vitro experiments, esomeprazole pallets dispersion passed through feeding tubes using gentle syringe pressure to develop a clog-free dispersion-delivery method. Nasogastric tube (8-French [Fr]) and diluents (different pH of water used i.e. pH 5.5, 7.0 and 8.5) were tested. The results showed excellent delivery of esomeprazole pellets using water as a medium for tube delivery. Recovery of esomeprazole pallets dispersion in different pH of water i.e. pH 5.5, 7.0 and 8.5 at “0 and 15” minutes incubation time were nearly 100% in 8-Fr nasogastric tubes. Keywords: Esomeprazole, Stress degradation, Stability indicating assay method, Nasogastric Tube.
A systematic review on SARS-COVID-2: Risk and its comorbidities
Authors: VP Dharani Shrinivasan , Ramalingam Kameswaran , Madasamy Senthil , Ramanathan Sambathkumar
Published: March 2022

Since 2019 November, an outbreak of COVID-19 arose and became a major public health emergency of international concern. A comprehensive case series from China was published by the New Coronavirus Pneumonia Emergency Response Epidemiology Team, which indicated an overall fatality rate of 2.3 percent, which climbed to 6.0 percent in persons with high blood pressure. The elderly and people with underlying medical problems, such as cardiovascular disease, diabetes, chronic respiratory diseases and cancer are more likely to develop serious illnesses. An electronic literature search was carried out by the search engines like PUBMED, Google scholar, etc. Comorbidities included in this study such as diabetes, hypertension, asthma, cardiovascular risk factors, cerebrovascular conditions. The result was that most of the comorbid causes were hypertension. By the above systemic review, it was concluded that the most comorbid condition is hypertension followed by diabetes mellitus, hence the mortality rate also seems to be higher in these two cases. Keywords: COVID-19, Comorbidities, Clinical investigations, Morbidity and mortality, Hypertension and diabetes mellitus.
Human spermatogonia stem cells (SSCS) in a culture system with platelet rich plasma and correlations with spermatogenesis level
Authors: Lestari Silvia W , Aditya Debby , Husna Firda Asma’ul , Pratama Gita , Suryandari Dwi Anita , Sumapradja Kanadi , Margiana Ria , Sari Puji , Kodariah Ria
Published: March 2022

There are instances when the sperm fail to be obtained from the testes in assisted reproductive technology (ART) of azoospermia infertility due to spermatogenesis arrest. Therefore, spermatogonial stem cells (SSCs) may be used as an alternative management. Platelet rich plasma (PRP) is a concentrated source of growth factors that support the proliferation and differentiation of stem cells in vitro. The objective of this study was to determine the efficiency of PRP in supporting SSCs proliferation and differentiation and to assess the correlation between the level of spermatogenesis and the potency of proliferation and differentiation of SSC in vitro. SSCs were isolated from seven testicular tissue samples using sperm extraction (TESA/TESE) and were then further cultured into two groups, PRP and FBS. The resulting cells were quantitatively assayed by qRT-PCR towards the expression of PLZF, OCT4, and CKIT. The level of spermatogenesis was assessed from the histology measurement using Johnson scoring. Apoptosis was evaluated using the TUNEL and immunocytochemistry methods. This study showed that PLZF, OCT4, and CKIT were expressed in the resulting cell culture. The difference was statistically insignificant among PRP and FBS. There was a positive correlation between the potency of proliferation and differentiation of SSCs toward the level of spermatogenesis. PRP may support the maintenance of proliferation and differentiation of SSCs in vitro and could be developed as an alternative of FBS in the SSCs culture system. Keywords: Spermatogonial stem cells, Platelet rich plasma, Fetal bovine serum, Spermatogenesis, Cell culture.
Politik Uang di Pemilu Indonesia: Sebuah Tinjauan
Authors: Hamson Zulkarnain
Published: March 2022

Politik uang di Pemilihan Umum (Pemilu), nasional maupun lokal, telah menjadi bagian yang tidak terpisahkan dalam perkembangan demokrasi di Indonesia. Kajian ini bertujuan mengungkapkan penyebab timbulnya politik uang di pemilu nasional maupun lokal. Kajian ini menggunakan data jurnal yang terbit dan dipilih dalam kurun waktu 2015 hingga 2019. Hasilnya kajian ini memberikan gambaran praktik jual beli suara, telah menjadi bagian yang tidak terkendali dalam pelaksanaan Pemilu, baik lokal maupun nasional di Indonesia. Pemilu nasional maupun pemilu lokal, telah terkontaminasi dengan prilaku uang. Implikasi penting kajian ialah politik uang dalam pemilu perlu segera mendapat perhatian dan solusi terbaik, karena akan menjamin kestabilan dan kualitas demokrasi Indonesia di masa depan. Metodologi yang digunakan meliputi: 1) mendefinisikan pertanyaan penelitian; 2) penentuan sumber literatur; 3) penentuan kata kunci pencarian literatur; 4) Pemilihan literatur; dan 5) mengekstrak data. Berdasarkan metodologi, hasil yang diperoleh berisi 10 makalah. Ada 10 studi yang mengangkat topik politik uang dalam pemilu, baik lokal maupun nasional, dan berbagi pengetahuan yang menjelaskan bahwa kedua komponen tersebut saling mempengaruhi. Kajian lanjutan boleh dilakukan dengan meneliti sejauh mana politik uang boleh digunakan sebagai biaya politik dalam kampanye, namun terkontrol dan tidak melanggar aturan hukum.
Strategi Komunikasi Pemasaran Online Shop Brand Mabello Melona Dalam Menarik Minat Konsumen Di Makassar
Authors: Adiba Fahmi , Nahdiana Nahdiana , Rahayu Pramudita Budi
Published: March 2022

Penelitian ini bertujuan untuk mengetahui strategi komunikasi pemasaran berbasis online serta model strategi komunikasi yang dilakukan oleh Mabello Melona dalam meningkatkan minat pembelian produk Mabello. Metode yang digunakan dalam penelitian ini adalah deskriptif kualitatif yang berusaha menyajikan fakta dan temuan secara mendalam melalui penjelasan deskriptif.sumber data didapatkan melalui wawancara dan observasi terhadap informan utama yang kemudian dianalisis dengan metode triangulasi data. Hasil penelitian menunjukkan jika Mabello Melona melakukan strategi komunikasi pemasaran berbasis online dengan menggunakan media social instagram dan tiktok serta penggunaan aplikasi shopee sebagai media penjualan utama. Selain itu model strategi yang dilakukan adalah dengan menggunakan strategi perilklanan melalui instagram ads, tik tok ads, serta menngunakan endorsement dari public figure lokal dan nasional. Sementara dalam upaya promosi penjualan dilakukan dengan memberikan giveaway, diskon dan penjualan paket
El espacio vivido. Hacia una etnografía radicalmente urbana
Authors: Espinosa Zepeda Horacio
Published: March 2022

Con este ensayo intento delimitar una metodología propia para la etnografía urbana pero no sin antes problematizar su objeto de estudio. Históricamente, lo urbano, o bien se ha entendido como una consecuencia de la sociedad industrial y por lo tanto prefigurado en la estructura económica, o bien como una consecuencia de la planeación urbana y por lo tanto prefigurado en el proyecto del Arquitecto. Cuando lo urbano ha tenido un estatus diferencial, ha sido en términos anómicos como en el caso de Simmel o pastorales como en el caso de la Escuela de Chicago. Este ensayo se divide en tres partes: un intento de definición lefebvriana de lo urbano en tanto “espacio vivido”, una serie de reflexiones epistemológicas con la intención de crear un marco metodológico para la etnografía urbana y, finalmente, una última parte donde se enumeran una serie de técnicas para el abordaje de lo urbano. Más cercano a un manifiesto inconformista que a un manual, podríamos decir que se trata de un anti-manual. Mi planteamiento es que, en última instancia, lo urbano es aquella parte elusiva de la experiencia de ciudad, y, por lo tanto, requiere métodos acordes a su irreductibilidad.
La lucha de las mujeres indígenas de la Amazonía ecuatoriana por la defensa de sus cuerpos-territorios
Authors: Marotta Ramona
Published: March 2022

Hoy en día, las mujeres indígenas de la Amazonía ecuatoriana se perfilan como “nuevas actoras sociales”, y sus luchas adquieren cada vez más visibilidad a nivel nacional e internacional. Partiendo de una etnografía digital realizada durante la pandemia, en este artículo me propongo analizar el papel que ocupan hoy estas subjetividades en la defensa de sus territorios, amenazados por las políticas neoextractivistas, y de sus derechos. En este sentido, la marginación sociopolítica que históricamente les ha excluido de los espacios de decisión, les lleva hoy a desarrollar y reivindicar formas de organización autónomas en defensa de sus “cuerpos-territorios”.
A formação de professores no curso de letras e a importância da língua portuguesa nas séries finais do ensino fundamental
Authors: Sousa Alex Montel de
Published: March 2022

Este artigo tem a finalidade de apresentar algumas considerações sobre a formação de professores no curso de Letras e sua relevância para a qualidade do ensino de Língua Portuguesa ministrado nas séries finais do Ensino Fundamental nas escolas de educação básica. Faz referência à origem do processo de formação de professores no Brasil e algumas considerações relevantes sobre formação continuada em benefício das disciplinas que fazem parte do currículo de Língua Portuguesa uma vez associadas a teoria e as práticas de ensino ministradas nos cursos de ensino superior. É utilizado como instrumento de pesquisa, o método de pesquisa bibliográfico de cunho descritivo com base na análise exploratória que objetivou trazer para fins de conhecimento a importância da formação de professores para o exercício da prática educativa desenvolvida nas escolas de educação básica de todo o país. As reflexões expostas no presente estudo, são baseadas nas considerações de Saviani (2009), Andrade (2007), Murray (1995), Ribeiro (2003), Fusari (2000) e Antunes (2003) que entre outros autores foram fundamentais em sua construção.
Incidental diagnosis of ochronosis by aortic valve replacement
Authors: Çoban Özgür , Ali Uçak Hacı , Ahmet Güldür Muhammet , Özsöyler İbrahim
Published: March 2022

Alkaptonuria is a rare inherited metabolic disease caused by homogentisic acid oxidase enzyme deficiency. Homogentisic acid formed during phenylalanine and tyrosine metabolism cannot be further metabolized and accumulates due to this enzyme deficiency. Some of the homogentisic acid that cannot be removed by metabolism is excreted with urine, some of it causes this accumulation known as ochronosis, which is characterized by dark pigmented color change in tissues. The classic clinical triad of the disease is darkening of the urine color, degenerative arthritis in the joints and dark colored pigmentation in the connective tissue. Herein, we present a case of ochronosis detected incidentally during aortic valve replacement with the diagnosis of aortic insufficiency.
Comparison of percutaneous access and open femoral cutdown in elective endovascular aortic repair of abdominal aortic aneurysms
Authors: Akbulut Mustafa , Ak Adnan , Arslan Özgür , Faruk Akardere Ömer , Zehra Karakoç Ayşe , Gume Serkan , Şişmanoğlu Mesut , Altuğ Tuncer Mehmet
Published: March 2022

Background: The aim of this study was to compare postoperative outcomes of percutaneous access and femoral cutdown methods for elective bifurcated endovascular abdominal aortic aneurysm repair.

Methods: Between November 2013 and September 2020, a total of 152 patient (135 males, 17 females; mean age: 70.6±6, range, 57 to 87 years) who underwent endovascular repair due to infrarenal abdominal aortic aneurysm were retrospectively analyzed. According to femoral access type, the patients were grouped into two groups as the total percutaneous femoral access and open cutdown femoral access endovascular repair. Intra- and postoperative data were compared, including operative time, amount of contrast media, bleeding requiring transfusion, return to the operating room, access vessel complications, wound complications, and overall length of hospital stay.

Results: Eighty-seven (57.2%) femoral cutdown access repair and 65 (42.8%) percutaneous femoral access repair cases were evaluated in the study. The two groups were comparable in terms of demographic and clinical characteristics (p>0.05), except for chronic obstructive pulmonary disease which was more frequent in the percutaneous access group (p=0.014). After adjustment, age, diabetes mellitus, chronic obstructive pulmonary disease, and obesity were not predictive of percutaneous access failure. Percutaneous femoral access was observed as the only preventing factor for wound infection (odds ratio=0.166, 95% confidence interval: 0.036-0.756; p=0.021).

Conclusion: Although femoral access preference does not affect mortality and re-intervention rates, percutaneous endovascular repair reduces operation time, hospital stay, and wound site complications compared to femoral artery exposures.