bluuebunny/crossref_metadata_2025 huggingface dataset:
Cross-sectional study of quality of life impairment of adult female acne patients
Authors: Anaba Ehiaghe L , Cole-Adeife Motunsope Olufolakemi
Published: June 2021

The effect of acne vulgaris on the quality of life of adult females is not readily documented nor the factors that impair quality of life in these adult females. The aim of this study was to document quality of life impairment and the factors that affect this quality of life in adult female acne patients. The study was a prospective cross sectional study of 56 adult female acne patients aged 25 years and above. Socio-demographic data, clinical examination were documented with a study proforma. Quality of life was assessed using Cardiff Acne Disability Index (CADI). Data was analysed using SPSS version 22. Mean of independent groups were compared using Students ‘t’ test while Chi squared test was used to compare categorical variables. For all statistical tests, P value <0.05 was adjudged to be significant. The mean age of the participants was 33.4± 8.2 and mean CADI was 6.6±3.8, minimum CADI was 2 and maximum was 15. Quality of life impairment was mild, moderate and severe in 35.7%, 37.5% and 26.8% respectively. The items affected in the CADI index were questions about “Perception of how bad pimples were,” “Feelings about appearance of skin,” and “Aggression, frustration and embarrassment.” Factors associated with quality of life impairment were age, post inflammatory hyperpigmentation, presence of scarring. Quality of life is impaired by acne in adult females. This impairment is made worse by age, presence of scarring and post-inflammatory hyperpigmentation and not marital status, level of education and a family history of acne.
Quantitative, structural and molecular changes in neuroglia of aging mammals: A review
Authors: Pannese Ennio
Published: June 2021

The neuroglia of the central and peripheral nervous systems undergo numerous changes during normal aging. Astrocytes become hypertrophic and accumulate intermediate filaments. Oligodendrocytes and Schwann cells undergo alterations that are often accompanied by degenerative changes to the myelin sheath. In microglia, proliferation in response to injury, motility of cell processes, ability to migrate to sites of neural injury, and phagocytic and autophagic capabilities are reduced. In sensory ganglia, the number and extent of gaps between perineuronal satellite cells – that leave the surfaces of sensory ganglion neurons directly exposed to basal lamina– increase significantly. The molecular profiles of neuroglia also change in old age, which, in view of the interactions between neurons and neuroglia, have negative consequences for important physiological processes in the nervous system. Since neuroglia actively participate in numerous nervous system processes, it is likely that not only neurons but also neuroglia will prove to be useful targets for interventions to prevent, reverse or slow the behavioral changes and cognitive decline that often accompany senescence.
How to Treat Proximal and Middle One-Third Humeral Shaft Fractures: The Role of Helical Plates
Authors: Nicolaci Giulia , Lollino Nicola
Published: June 2021

Complex proximal third diaphyseal humeral fractures are uncommon patterns of injury mainly caused by high energy trauma. The anatomical shape of the humerus, the presence of the deltoid tuberosity and the close proximity of the radial nerve into the radial groove represent challenge elements to deal with. Historically, straight plates were manually twisted; subsequently, helical plates created for other anatomical sites (as distal tibia) were used in humeral fractures. In both these experiences surgeons observed several disadvantages. More recently, dedicated helical plates have been created. In this study, we expose our surgical technique for using helical humeral plates (A.L.P.S.® Proximal Humeral Plating System, Zimmer Biomet), with its advantages and operative recommendation. From 2019 to 2021, nine patients who were admitted to our institution for humeral fractures involving the proximal third diaphysis have been treated with humeral helical plates. At one and six months after surgery, standard antero-posterior and lateral radiographs were obtained, and at last follow-up (fourteen months on average) clinical evaluation was performed through range of motion assessment, Constant score and DASH score questionnaires. At six months, all fractures have healed. At last follow-up (fourteen months on average, 6–22) the average range of motion were flexion 135° (90–180°); abduction 124° (85–180°); external rotation 52° (20–80°), internal rotation at L3 (between scapulae-trochanter). Average Constant Shoulder Score was 70 (33–96), average Dash score was 21 (range 1,7–63). Three patients experienced temporary radial nerve palsy from injury, with subsequently improvement at EMG analysis within eight months from surgery. In our opinion this strategy avoids the deltoid tuberosity and reduces the risk of radial nerve injury, increasing the possibility of a rapid functional recovery after surgery.
Diagnostic value of microRNA-106a-5p in patients with psoriasis and its regulatory role in inflammatory responses
Authors: Miao Xiaolin , Tong Xinyun , Hu Jingsang , Wang Juan
Published: June 2021

Background:

Psoriasis is a multifactorial, recurring, and chronic inflammatory skin disease.

Objectives:

This study was designed to explore the potential role of microRNA-106a-5p (miR-106a-5p) in psoriasis.

Methods:

The expression levels of miR-106a-5p in the serum of psoriasis patients and healthy individuals were detected by quantitative real-time polymerase chain reaction. The diagnostic value of miR-106a-5p in serum was evaluated by the receiver operating characteristic (ROC) curve. The levels of interleukin-22 (IL-22), IL-17A, and tumor necrosis factor-alpha (TNF-alpha) were determined by enzyme-linked immunosorbent assay. Dual-luciferase reporter assay was used for the target gene verification.

Results:

The serum expression of miR-106a-5p was found to be upregulated in psoriasis patients. ROC curve showed that miR-106a-5p had high specificity and sensitivity in the diagnosis of psoriasis. The correlation between the serum expression level of miR-106a-5p and Psoriasis Area and Severity Index was positive. The relative expression levels of IL-17A, IL-22, and TNF-alpha in serum of psoriasis patients were significantly upregulated compared with that in healthy controls, and showed a positive association with serum miR-106a-5p levels. Cell experiments demonstrated that upregulation of miR-106a-5p could promote cell proliferation, and the levels of IL-22, IL-17A, and TNF-alpha were upregulated significantly in M5-induced HaCaT cells. Phosphatase and tensin homolog was proved to be the target gene of miR-106a-5p.

Conclusion:

Considering the novel and vital role in psoriasis progression, miR-106a-5p is expected to be a new potent target for the treatment of psoriasis. MiR-106-5p was expected to use for more immunity diseases research and therapy.
Obesity in inflammatory bowel disease
Authors: Johnson Amanda M. , Loftus Edward V.
Published: June 2021

In contrast to previous perceptions that inflammatory bowel disease (IBD) patients are generally malnourished and underweight, there is mounting evidence to suggest that rates of obesity in IBD now mirror that of the general population. IBD is an immune-mediated condition that appears to develop in individuals who have not only a genetic predisposition to immune dysregulation but also likely exposure to various environmental factors which further potentiate this risk. With the surge in obesity alongside the rising incidence of IBD, particularly in developing nations, the role that obesity may play, not only in the pathogenesis but also in the natural history of disease has become a topic of growing interest. Currently available data exploring obesity's impact on the natural history of IBD are largely conflicting, potentially limited by the use of body mass index as a surrogate measure of obesity at varying time points throughout the disease course. While there are pharmacokinetic data to suggest possible detrimental effects that obesity may have on the response to medical therapy, results in this realm are also inconsistent. Moreover, not only is it unclear whether weight loss improves IBD outcomes, little is known about the safety and efficacy of available weight-loss strategies in this population. For these reasons, it becomes increasingly important to further understand the nature of any interaction between obesity and IBD.
Molecular characterization of colorectal cancer
Authors: Liang Qiankun , Du Xiaojuan , Mao Lanfang , Wang Guopan
Published: June 2021

Background:

Colorectal cancer (CRC) is one of the most common cancers worldwide. RNA-binding proteins (RBPs) regulate essential biological processes and play essential roles in a variety of cancers. The present study screened differentially expressed RBPs, analyzed their function and constructed a prognostic model to predict the overall survival of patients with CRC.

Methods:

We downloaded CRC RNA-sequencing data from the Cancer Genome Atlas (TCGA) portal and screened differentially expressed RBPs. Then, functional analyses of these genes were performed, and a risk model was established by multivariate Cox regression.

Results:

We obtained 132 differentially expressed RBPs, including 66 upregulated and 66 downregulated RBPs. Functional analysis revealed that these genes were significantly enriched in RNA processing, modification and binding, ribosome biogenesis, post-transcriptional regulation, ribonuclease and nuclease activity. Additionally, some RBPs were significantly related to interferon (IFN)-alpha and IFN-beta biosynthetic processes and the Toll-like receptor signaling pathway. A prognostic model was constructed and included insulin like growth factor 2 messenger ribonucleic acid binding protein 3 (IGF2BP3), poly (A) binding protein cytoplasmic 1 like (PABPC1L), peroxisome proliferator activated receptor gamma coactivator 1 alpha (PPARGC1A), peptidyl- transfer ribonucleic acid hydrolase 1 homolog (PTRH1) and tudor domain containing 7 (TDRD7). The model is an independent risk factor for clinicopathological characteristics.

Conclusion:

Our study provided novel insights into the pathogenesis of CRC and constructed a prognostic gene model, which may be helpful for determining the prognosis of CRC.
Linear independence in linear systems on elliptic curves
Authors: Brock Bradley W. , Jordan Bruce W. , Poonen Bjorn , Scholl Anthony J. , Wetherell Joseph L.
Published: June 2021

Let

E

be an elliptic curve, with identity

O

, and let

C

be a cyclic subgroup of odd order

N

, over an algebraically closed field

k

with char

k \nmid N

. For

P \in C

, let

s_P

be a rational function with divisor

N \cdot P - N \cdot O

. We ask whether the

N

functions

s_P

are linearly independent. For generic

(E,C)

, we prove that the answer is yes. We bound the number of exceptional

(E,C)

when

N

is a prime by using the geometry of the universal generalized elliptic curve over

X_1(N)

. The problem can be recast in terms of sections of an arbitrary degree

N

line bundle on

E

.
Finite entropy vs finite energy
Authors: Di Nezza Eleonora , Guedj Vincent , Lu Chinh H.
Published: June 2021

Probability measures with either finite Monge–Ampère energy or finite entropy have played a central role in recent developments in Kähler geometry. In this note we make a systematic study of quasi-plurisubharmonic potentials whose Monge–Ampère measures have finite entropy. We show that these potentials belong to the finite energy class

\mathcal{E}^{\frac{n}{n-1}}

, where

n

denotes the complex dimension, and provide examples showing that this critical exponent is sharp. Our proof relies on refined Moser–Trudinger inequalities for quasi-plurisubharmonic functions.
Impact of COVID-19 on Nutrition, Food Security, and Dietary Diversity and Quality in Burkina Faso, Ethiopia and Nigeria
Authors: Madzorera Isabel , Ismail Abbas , Hemler Elena C. , Korte Michelle L. , Olufemi Adedokun A. , Wang Dongqing , Assefa Nega , Workneh Firehiwot , Lankoande Bruno , Chukwu Angela , Ourohire Millogo , Mattei Josiemer , Soura Abdramane , Berhane Yemane , Sie Ali , Oduola Ayoade , Fawzi Wafaie W.
Published: June 2021

Coronavirus disease 2019 (COVID-19) can have far-reaching consequences for developing countries through the combined effects of infection and mortality, and the mitigation measures that can impact food systems and diets. Using a mobile platform, this cross-sectional study evaluated the effect of COVID-19 on food prices and dietary quality for 1797 households in Nouna and Ouagadougou in Burkina Faso, Addis Ababa and Kersa in Ethiopia, and Lagos and Ibadan in Nigeria. We assessed the consumption of 20 food groups during the previous 7 days. The dietary diversity scores (DDS) and Prime Diet Quality Scores (PDQS) were used to assess dietary diversity and quality. We used generalized estimating equation (GEE) linear models to evaluate associations between price changes for staples, pulses, vegetables, fruits, and animal source foods (ASFs) with the DDS and PDQS PDQS. Most participants reported increasing prices of staples, pulses, fruits, vegetables and ASF, and ≥ 40% reported the decreased consumption of staples, legumes, and other vegetables and fruits. The DDS (except in Kersa and Ouagadougou) and PDQS were lower during the COVID-19 pandemic. Higher pulse prices were associated with lower DDS (estimate, −0.35; 95% confidence interval [CI], −0.74 to 0.03; P = 0.07) in the combined analysis and in Burkina Faso (estimate, −0.47; 95% CI, −0.82 to −0.11). Higher vegetable prices were positively associated with the DDS (estimate, 0.22; 95% CI, 0.08 to 0.37). Lower crop production (estimate, −0.54; 95% CI, −0.80 to −0.27) was associated with lower DDS. The price increases and worsening dietary diversity and quality call for social protection and other strategies to increase the availability and affordability of nutrient-rich foods during the COVID-19 pandemic and public health emergencies.
Equivalence of Equipment Environmental Qualification Standards for Civil and Military Aircraft Equipment
Authors:   AE-4 Electromagnetic Compatibility (EMC) Committee
Published: June 2021

This document provides guidance for applying aircraft equipment electromagnetic, electrical, and mechanical qualification standards (i.e., DO-160, MIL-STD-461, MIL-STD-704, and MIL-STD-810) to civil aircraft certification intended for military use and for military aircraft equipment installed on civil aircraft. The guidance identifies where the equipment environmental qualification standards meet the intent of both the civil or military aircraft certification requirements. Conversely, the guidance will identify where the equipment environmental qualification standards have differences that do not meet the intent of the civil or military aircraft certification requirements and when these differences matter based on equipment criticality, installation location, and/or other variables.
Performance Test for Windshield Defrosting Systems for Off-Road, Self-Propelled Work Machines
Authors:   HFTC6, Operator Accommodation
Published: June 2021

SAE J3078/5 specifies a test method for testing defrosting systems. It is applicable to off-road self-propelled work machines as defined in SAE J1116 and agricultural tractors as defined in ANSI/ASAE S390. The full list of machines covered is included in Table 1.
Revisiting Consecutive Note-Taking: What, How, and in What Language?
Authors: Szabó Csilla
Published: June 2021

Note-taking is taught across the board at interpreter training institutions, but opinions as to ‘what’, ‘how’, and ‘in what language’ one should take notes often tend to be curiously mixed. This paper revisits the three main areas where there seems to be no strong consensus, namely: 1) What and how much should interpreters note down? 2) How should they take notes: by taking down full words, abbreviations or symbols? 3) In what language should they prepare their notes: in the source or target language, in A or B language or, irrespective of the direction, in an economical language such as English? This study explores these three questions by first revisiting prescriptive views put forward by practitioners over the past few decades; it then highlights some of the empirical studies conducted in these areas; and finally it proposes recommendations for trainers, based on the author’s experience as a trainer of consecutive interpreting.
Book Review: Words, Music and Gender (Michelle Gadpaille and Victor Kennedy, eds.)
Authors: Šporčič Anamarija
Published: June 2021

Words, Music and Gender is a collection of 17 contributions by scholars hailing from a variety of academic backgrounds, enabling the volume to cover an impressive array of ways in which gender, words and music intersect and intertwine.
18F-FDG PET/CT compared with ultrasound and biopsy for detection of vasculitis of the temporal artery branches
Authors: Rottenburger Christof , Mensch Noemi , Imfeld Stephan , Aschwanden Markus , Glatz Katharina , Staub Daniel , Berger Christoph T. , Daikeler Thomas
Published: June 2021

AIMS
To describe the feasibility and diagnostic accuracy of 18F-FDG positron emission tomography-computed tomography (PET/CT) of the temporal artery compared with temporal artery ultrasound and histology of the temporal artery in patients with suspicion of having giant cell arteritis (GCA).

MATERIALS AND METHODS
Patients with suspected GCA were included. PET/CT standard uptake value ratios and the compression sign on ultrasound were assessed for the trunk, and parietal and frontal branches of the temporal artery. Temporal artery biopsies were systematically re-assessed, if available.

RESULTS
In 17/34 patients, GCA was confirmed. Temporal artery PET/CT confirmed vasculitis in 9/17 patients and was negative in all 17 controls. Nineteen of 34 subjects had a temporal artery biopsy, which was positive in 7 patients. Five of these seven were negative in the preceding PET/CT. Ultrasound confirmed vasculitis in 9/17 patients and was negative in 16/17 controls. In 7/17 patients, PET/CT and ultrasound were positive for temporal arteritis. Two patients had positive findings only on temporal artery PET/CT and two patients showed vasculitis only on temporal artery ultrasound. No temporal artery segments <1.4 mm were positive on PET/CT. The parietal branches were PET/CT-positive in two patients only. In contrast, on ultrasound vasculitic findings were equally distributed amongst all branches. Sensitivity and specificity for identification of temporal artery involvement was 53% and 100% for PET/CT, and 53% and 94% for ultrasound, respectively.

CONCLUSIONS
Assessment of the temporal artery with PET/CT is a valuable extension in the diagnostic workup for GCA. PET/CT and ultrasound have comparable diagnostic accuracy, but differ on a segment and a patient level and may thus be used as complementary tests. PET/CT has a lower sensitivity for the parietal branch than ultrasound and histology.
Factors Affecting Self-Censorship Among Polish Journalists
Authors: Stępińska Agnieszka
Published: June 2021

The aim of this paper is to recognize the factors limiting journalists’ sense of autonomy and affecting the level of their self-censorship during the last three decades of the post-transformation period. The issue will be addressed two-fold. First, we will analyze changes in the journalists’ perception on their professional autonomy. Second, we will examine trends in relations between the political system and media system in Poland since the 1990s. The findings show that in the 1990s journalists were still much more concerned about the political factors which could affect their work than about the economic ones. A decade later they had become much more aware of the economic pressures on their profession, such as owners’ expectations and market-driven journalism. In the last few years, however, the constant pressure of ongoing government reforms aimed at bringing the press under tighter political control, as well as the emphasis on ‘national’ content, has already led to some degree of self-censorship on the part of journalists.
Trust in Journalists in the Light of Survey Findings Gathered from Members of the Journalistic Profession
Authors: Świerczyńska-Głownia Weronika
Published: June 2021

The aim of the research was to establish the factors that journalists consider to be of the greatest significance when building the audience’s trust. The research was conducted between the 5th of January and the 31st of January 2020 via a digital platform supporting survey studies. The questionnaire included 13 factual questions (2 open-ended and 11 closed-ended) and 3 questions designed to determine the profiles of 67 respondents. In order to address the research questions, statistical analyses of the feedback were performed using the IBM SPSS Statistics package. The research is the first stage of a research project focusing on the question of trust in journalists. The article complements and elaborates on the available research findings and scientific analyses concerning the community of Polish journalists.
Usos etnofarmacológicos de plantas en el tratamiento de enfermedades crónicas no transmisibles en Santiago de Cuba
Authors: Yero Haber Rut Benita , Escalona Arranz Julio César
Published: June 2021

Existe una marcada tendencia en la utilización empírica de plantas medicinales para el tratamiento de enfermedades crónicas no transmisibles siendo necesario el inventario de las mismas. En el presente trabajo se realizó un estudio etnofarmacológico, exploratorio y descriptivo, con enfoque cualitativo y cuantitativo en comunidades urbanas y rurales de Santiago de Cuba. Se entrevistaron un total de 100 pacientes, realizando la caracterización sociodemográfica y clínica de la comunidad; el análisis de las variables relativas al uso de plantas medicinales y la selección de especies vegetales con potencialidades para el desarrollo de estudios fitoquímicos y farmacológicos. Los entrevistados refirieron las especies más empleadas para el tratamiento de sus enfermedades crónicas, prevaleciendo el sexo femenino, el grupo de edades comprendido entre 40 y 59 años de edad y el nivel de escolaridad en la enseñanza técnico-profesional. Se informaron un total de 51 especies, agrupadas 34 familias. Las plantas con mayores niveles de uso significativo, índice de valor de uso e índice de fidelidad fueron, en el municipio Santiago de Cuba: Allium sativum L. y Ocimum gratissimum (L.) (IF=96%), Chamaemelum nobile L. y Eucalyptus maculata (IF=90%), mientras que en Songo La Maya: Calendula officinalis (L.), Carica papaya (L.) (IF=100%) y Citrus reticulate (IF=95.65%). Las especies con mayores potencialidades para futuros estudios fitoquímicos y farmacológicos resultaron ser: Eucalyptus maculata, Camellia sinensis, Ocimum gratissimum L, Psidium guajaba L, Persea americana, Anacardium occidentale L., Nasturtiumo fficinale R. Br, Zingiber officinale, Citrus paradise, Plectranthus neochillus Benth ex E. Meg y Dichrostachys cinerea (L.) Wight &Arn.
Percepción de la comunicación del farmacéutico desde farmacias comunitarias del municipio Santiago de Cuba
Authors: Aldana Laterrade Alicia , Megret Despaigne Rosario , Garzón Feria Maislin , Brugal Mustelier Elinay
Published: June 2021

La comunicación activa del farmacéutico garantiza la adherencia terapéutica y la satisfacción del paciente. Se realizó un estudio del tipo observacional, descriptivo y transversal con el objetivo de evaluar la percepción de la comunicación del farmacéutico desde cinco farmacias comunitarias del Municipio Santiago de Cuba, en el segundo semestre de 2019. La muestra estuvo conformada por 36 farmacéuticos, cumpliéndose las normas éticas. Como instrumento de trabajo se utilizó un cuestionario aplicado en el puesto laboral, los profesionales fueron caracterizados atendiendo a categoría ocupacional, años de práctica profesional y superación, valorándose los criterios de Recursos, Actitud y Visión, Formación y Regulatorio y Ambiente. Se determinó el nivel de percepción en favorable, poco favorable y desfavorable. Se realizó un análisis porcentual de los datos determinándose media y desviación estándar de los criterios. Los resultados demostraron que el 55,55% se desempeñó como Dependientes de Farmacia, seguido de los Licenciados en Ciencias Farmacéuticas y en Tecnología de la Salud que representaron el 33,33% y por último los Técnicos en Farmacia (11,11%). Existió mayor prevalencia entre 6-12 años de experiencia profesional para un 52,78%, se halló que solo el 5,55% ha continuado sus estudios de formación posgraduada a nivel de maestría. Resultaron poco favorable los criterios: Recursos y Regulatorio y ambiente, mientras que Actitud y visión y Formación fueron favorables. La percepción resultó favorable para un 55,55%, seguida de la poco favorable en 30,55% y desfavorable un 13,88%. Los farmacéuticos percibieron como favorable la comunicación con el paciente en las farmacias comunitarias estudiadas.
Causas de muerte y hallazgos necrópsicos en fallecidos por cirrosis hepática durante el decenio de 1991-2000 en Santiago de Cuba
Authors: Castillo Duany María Isabel
Published: June 2021

Se realizó un estudio descriptivo, transversal y retrospectivo con el objetivo de describir las principales causas de muerte y hallazgos necrópsicos en fallecidos por Cirrosis Hepática en el Hospital Provincial Clínico Quirúrgico Docente “Saturnino Lora”, en Santiago de Cuba, durante el decenio de 1991-2000. Los resultados demostraron pérdidas de años de vida potencialmente perdidos y el incremento progresivo de la frecuencia de necropsia, de la mortalidad a partir de los 55 años con predominio del sexo masculino y trabajadores, así como el aumento de la mortalidad en los primeros siete días de estadía hospitalaria. La insuficiencia hepática aguda y la bronconeumonía bacteriana resultaron ser las principales causas directas de muerte y como resultado relevante en los hallazgos necrópsicos se destacaron la ascitis, esplenomegalia y ateroesclerosis de la aorta y sus ramas. En la clasificación etiológica de los fallecidos la Cirrosis Portal y la post-necrótica constituyeron las más representativas.
KAUZA UGOVORNE OBAVEZE
Authors:   State University of Novi Pazar, Manić Samir
Published: June 2021

The paper discusses the impact of the reasons for the commitment on the validity of the contract. Due to the fact that most institutes of modern law find their origin in Roman law, the paper begins by presenting the role of the cause of obligation in Roman law. The author then analyzes the causal and anti-causal views of legal theory, all in order to emphasize the fact that the cause of the contractual obligation is theoretically a very controversial institute of the law of obligations. The last part of the paper is dedicated to the cause of contractual obligation in our contract law. Starting from the fact that the Law on Obligations accepts with its provisions the subjective and objective conception of the cause of the contractual obligation, the author points out that the objective conception of the cause of the contractual obligation, accepted through art. 51. ZOO, is a redundant institute that has no greater practical significance and which is successfully replaced by other institutes of law of obligations.
KAKO OCIJENITI KLjUČNE SUDIONIKE U RASPLITANjU PROBLEMA DEVIZNE KLAUZULE U ŠVICARSKIM FRANCIMA ILI GORDIJSKOG ČVORA „SUI GENERIS“
Authors:   Faculty of Law, University of Split, Kačer Hrvoje , Kačer Blanka , Olujić Domagoj
Published: June 2021

In this text, the authors have tried to approach the problem known as the CHF problem, in addition to providing a range of information, from a new aspect. Starting from the fact that no problem is limited to itself, but the conclusions drawn can be used, in an appropriate way, to other problems, they tried to assess how the participants, especially the courts and the state, behaved. Unfortunately, without compromising goodwill, the deserved grade is, primarily due to slowness, very low. Neither the courts (which are somewhat justified by formal reasons) nor the legislator have even remotely seized the opportunity to resolve the problem that has arisen as quickly and as completely (legally) as possible. There is no answer to the question why the highest courts did not use the opportunity to give their opinion on as many issues as possible they knew that have arisen or will arise, why the legislator did not use the possibilities of authentic interpretation or retroactive effect.
POJEDINA ZNAČAJNA PITANjA RESTITUCIJE O ZLOUPOTREBI PRIVATIZACIJE I KVALITETU USLUGA
Authors:   Faculty of Law, University of Kragujevac, Palević Milan
Published: June 2021

In this paper, the author tries to emphasize the importance of international and positive legal guarantee of property rights as well as the issue of return of confiscated property or market compensation, and especially to come to conclusions that would help better respect the human right to peaceful enjoyment of property. In that sense, certain judgments of the European Court of Human Rights were analyzed. Special attention in the paper is paid to the types of restitution and the low coefficient of compensation, which violates and calls into question the fairness of the process itself. A brief critical review of the privatization process was also made. Thus, it was pointed out that the restitution procedure should have been carried out first, and then privatization. The poor quality of services as a result of abuses in privatization was also pointed out.
USLUGE HUMANITARNIH ORGANIZACIJA
Authors:   Faculty of Law, University of Kragujevac, Bataveljić Dragan
Published: June 2021

The author of this work point to the fact that humanitarian organizations are the part of non-profit sector which are established and work in order to achieve general welfare of the individuals, particular social groups or society in whole. What is important to emphasize is that they belong to so called, voluntary sector whose work is transparent and is based on the laws of the country in which they operate. Each humanitarian organization has its own strategic plan, which as a written document, is aimed at achieving basic program goals. The monitoring of the implementation of adopted projects and the control of the management process are the mandatory (final) phases of their work. Humanitarian organizations as the part of non-state sector today play increasing role in offering services in various fields of social life to a wide range of beneficiaries. 0 It is interesting to note that these organizations are more present in developing countries and the countries in transition, particularly in the field of social services. The grounds for this situation can be found in the decentralization process and new, modified apprehension of the role of the state in the work of the growing number humanitarian organizations and movements. Namely, decentralization allows the delegation of powers and tasks from the central to local government levels and this is the main reason for rapid expansion of non-government sector on the global level and increasing participation of non-government sector in service providing.
BIBLIOTEKA OKTAVIJINOG TREMA (BIBLOTHECA PORTICUS OCTAVIAE)
Authors:   Faculty of Law, University of Kragujevac, Vladetić Srđan
Published: June 2021

Bibliotheca Porticus Octaviae, was one of the three public libraries that have been open in the time of the Augustus. In the work some of the questions that still remain unanswered will be analyzed, Some of those questions are: by whom the library has been built, to who it was dedicated and who made that dedication, and where it was located. In addition, we analyze questions of the library's collection, how it's been improved and enlarged and library's internal organization necessary for the providing of the services.
NEKA PITANjA DIGITALIZACIJE MEDIJSKIH USLUGA
Authors:   Faculty of Law, University of Kragujevac, Vučković Jelena
Published: June 2021

Life in the period of the fourth industrial revolution, complete and comprehensive digitization of almost every segment of human life, brings with it new challenges of recognition, understanding and coping in the digital environment. The crisis caused by the Covid-19 virus has further encouraged forms of virtual communication, and accelerated the development of digital services and their provision to unimaginable limits. The paper analyzes the way in which the digital environment influences the change in the way of providing media services, which are increasingly digital, and less classic and traditional. This means meeting and confronting a lot of information on the Internet and new social networks, which are becoming an alternative medium. younger population. Living in a digitized, hypertechnologically mediated world leads to the quantitative nature of information, without clearly determining its quality. A lot of information also leads to a lot of misinformation and false news. The appearance of the so-called algorithmic echo chambers, "clickbait" journalism, an increase in hate speech, as well as a decrease in trust in both the mainstream media and the journalistic profession in general. Therefore, in addition to strengthening the legal capacity of Internet regulation and the responsibility of digital service providers for the quality of audio-visual media content, it is important to pay attention to an important segment of preventive social action - development and strengthening of media literacy. Media literacy is one of the key competencies for living and working in a digitized and mediated environment, so it is necessary to clearly define its concept.
OSVRT NA PRAVA DECE SA INVALIDITETOM SA TEŽIŠTEM NA PRISTUP ZDRAVSTVENIM USLUGAMA
Authors:   Faculty of Law, University of Kragujevac, Vlašković Veljko
Published: June 2021

It is no coincidence that the UN Convention on the Rights of Persons with Disabilities is the first international human rights treaty in the 21st century. The Convention seeks to amend the social and legal status of persons with disabilities, including children, in a revolutionary way. The main goal is to remove social barriers by adopting a social model of disability in recognizing and exercising the human rights of persons with disabilities on an equal basis with other persons. Therefore, it is understandable that the rules of earlier international human rights treaties, such as the UN Convention on the Rights of the Child or the European Convention on Human Rights, are beginning to be directly adjusted to the this Convention. From the aspect of recognition and exercising of the rights of children with disabilities, the issue of accessibility to health care services is especially important. It insists on the application of the principles of reasonable accommodation, accessibility and non-discrimination so that children with disabilities have access to health care facilities on an equal basis with other children. This implies significant involvement of the state, local community and family in order to remove social and infrastructural barriers. Furthermore, the UN Committee on the Rights of Persons with Disabilities calls for an absolute ban on the forced detention and placement of children in health care facilities, while there is a very negative attitude towards the care of children with disabilities in social protection institutions. In this regard, an amendment to the domestic Law on the Protection of Persons with Mental Disabilities is required. According to the social model of disability, the family environment with the appropriate and effective support of the local community is a necessary environment for the realization of the rights of children with disabilities. When it comes to the consent of a child with a disability to a medical treatment, it is necessary to determine the child's capability to form views, as in the case of other children. In that sense, the mentioned child should be provided with appropriate assistance and support to express his / her views. This support consists primarily in the way in which the child is informed about the proposed medical treatment.
TRANSPLANTACIJA ORGANA
Authors:   Institute of Comparative Law in Belgrade, Petrović Dragana
Published: June 2021

Even the mere mention of "transplantation of human body parts" is reason enough to deal with this topic for who knows how many times. Quite simply, we need to discuss the topics discussed from time to time !? Let's get down to explaining some of the "hot" life issues that arise in connection with them. To, perhaps, determine ourselves in a different way according to the existing solutions ... to understand what a strong dynamic has gripped the world we live in, colored our attitudes with a different color, influenced our thoughts about life, its values, altruism, selflessness, charities. the desire to give up something special without thinking that we will get something in return. Transplantation of human organs and tissues for therapeutic purposes has been practiced since the middle of the last century. She started (of course, in a very primitive way) even in ancient India (even today one method of transplantation is called the "Indian method"), over the 16th century (1551). when the first free transplantation of a part of the nose was performed in Italy, in order to develop it into an irreplaceable medical procedure in order to save and prolong human life. Thousands of pages of professional literature, notes, polemical discussions, atypical medical articles, notes on the margins of read journals or books from philosophy, sociology, criminal literature ... about events of this kind, the representatives of the church also took their position. Understanding our view on this complex and very complicated issue requires that more attention be paid to certain solutions on the international scene, especially where there are certain permeations (some agreement but also differences). It's always good to hear a second opinion, because it puts you to think. That is why, in the considerations that follow, we have tried (somewhat more broadly) to answer some of the many and varied questions in which these touch, but often diverge, both from the point of view of the right regulations and from the point of view of medical and judicial practice. times from the perspective of some EU member states (Germany, Poland, presenting the position of the Catholic Church) on the one hand, and in the perspective of other moral, spiritual, cultural and other values - India and Iraq, on the other.
DRŽAVNA REVIZIJA KAO SPECIFIČNA JAVNA USLUGA
Authors:   Faculty of Economics, University of Belgrade, Dabić Ljubiša
Published: June 2021

The subject of research is state audit as a public service - state audit and types, its main subjects and object. In the central part of the paper, the public service is conceptually defined, and then the similarities and differences between the state audit service and other types of services are highlighted. Among other things, it was stated that the state audit has certain characteristics, properties and specifics, which arise from the nature of its activities. In essence, those characteristics are its attributes. The aim of this paper is to determine the characteristics, properties and specifics of state audit as a public service and its distinction, primarily from other types of public services. Its purpose is to determine the specifics of the state audit. The results obtained in the research should serve scientific and applied purposes.
EKOLOŠKA ULOGA OPOREZIVANjA MOTORNIH VOZILA U REPUBLICI SRBIJI
Authors:   Faculty of Law, University of Kragujevac, Stojanović Predrag
Published: June 2021

The main objective of fiscal instruments in the service of environmental protection should be directed towards guiding the economic entities to rationally use scarce natural resources, as well as to utilise non-polluting substitutes in the direction of a healthier environment and energy efficiency. It is not difficult to note that the current legal framework in the Republic of Serbia respects basic international standards in the field of motor vehicle taxation. In terms of excise taxation, progress is also noticeable since the necessary differentiation of the tax rates for different excises on petroleum products has been implemented, from the point of view of their impact on the environment. However, observed through the prism of modern theoretical concepts of the socalled green taxation, many opportunities still appear to be inadequately and insufficienty used.
Cilt Lezyonlarının Sınıflandırılmasında Derin Öğrenme Tabanlı Bir Yöntem
Authors: GÖREKE Volkan
Published: June 2021

Cilt kanseri kötü huylu tümörlerin kontrolsüz çoğalması ile başlar. Dünya çapında sık karşılaşılan bir kanser türüdür. Uzman hekimler tarafından çıplak gözle incelemesi ve teşhis konulması güçtür. Bu yüzden bilgisayar destekli teşhis sistemleri hekimlere tanı koymada yardımcı olabilir. Bu sistemler günümüzde yapay zekanın bir türü olan derin sinir ağlarını yaygın olarak kullanır. Pek çok derin sinir ağı içeren çalışmada veri girişi olarak medikal görüntüler kullanılır. Ağ mimarisine bağlı olarak bu sistemler öznitelikleri kendi katmanlarında çıkarırlar. Bu çalışmada VGG16 ön eğitimli derin sinir ağı kullanılarak ilk önce ağ katmanlarından görüntülere ilişkin öznitelikler elde edilmiştir. Daha sonra yüksek miktarda veri içeren bu özniteliklerin boyutu azaltılmıştır. Böylece sınıflandırmada en iyi başarımı sağlayacak öznitelikler elde edilmiştir. Veri artırma algoritması kullanılarak elde edilen nümerik veri artırılmış ve CNN tür derin sinir ağında %96 sınıflandırma doğruluğu ve %100 AUC başarımı elde edilmiştir.
Erzurum Pasinler Bölgesi Perlitinin Geopolimer Üretiminde Kullanımının Araştırılması
Authors: AKBULUT Fatih , POLAT Rıza , FATMA KARAGÖL Fatma
Published: June 2021

Küresel ısınma ve iklim değişikliğine sebebiyet veren en önemli faktörlerden birisi atmosfere salınan CO2’dir. Bu gazın salınımının önemli bir miktarı (%6-8), dünyada en çok kullanılan yapı malzemesi olan çimento üretiminden kaynaklanmaktadır. Bu miktarın azaltılması amacıyla yaklaşık yirmi yıldır araştırmacılar, çimentoya alternatif sürdürülebilir bağlayıcı malzeme olan geopolimer üzerinde yoğun olarak çalışmaktadırlar. Geopolimerler, atık yan ürün olan uçucu kül, yüksek fırın cürufu vb. bir alümino-silikat kaynağı ve NaOH, Na2SiO3 vb. aktivatörlerden oluşmaktadır. Alümino silikat kaynağı olarak, amorf yapılı SiO2 ve Al2O3 içeren volkanik kül, kil, pomza vb. mineral malzemelerde kullanılmaktadır. Bu çalışmada ise, Erzurum Pasinler bölgesinde önemli miktarda bulunan ve alümino silikat içeren perlitten geopolimer üretimi araştırılmıştır. Bu amaçla temin edilen perlit, bağlayıcı olarak kullanılıp geopolimer betonlar üretilmiştir. Karışımlarda alkali aktivatör olarak yalnızca NaOH kullanılmıştır ve üretilen numunelere yapılan ön deneyler sonucunda 90°C’de 72 saat ısı kürü uygulanmıştır. Üretilen numunelerin su emme oranları, birim hacim ağırlıkları ve 3, 7, 28 ve 150 günlük basınç dayanımları tespit edilmiştir. Ayrıca numuneler %5 konsantrasyonlu HCl ve MgSO4 çözeltilerine, 50 çevrimlik donma-çözünme etkisine ve 300°C, 500°C ve 700°C yüksek sıcaklıklara maruz bırakılmıştır. Deneyler sonunda numunelerin mekanik ve fiziksel özellikleri tespit edilmiştir. Sonuç olarak, perlit esaslı geopolimer üretiminde aktivatör olarak NaOH tek başına kullanılarak 20,50 MPa basınç dayanımı elde edilmiştir. Durabilite açısından ise aynı dayanıma sahip normal Portland çimentolu betona göre iyi performans göstermiştir.
Lor Peynirlerinde Fekal Kaynaklı Esherichia coli, Klebsiella pneumoniae Aranması ve Antibiyotik Direnç Profillerinin Belirlenmesi
Authors: AYTAÇ Burcu , TANIŞ Hüseyin , AYGAN Ashabil , ERTAŞ Erdal
Published: June 2021

Bu çalışmada Kahramanmaraş’da satışa sunulan 30 adet lor peyniri örneği mikrobiyolojik olarak incelenmiş Esherichia coli ve Klebsiella pneumoniae’nın varlığı araştırılmıştır ve antibiyotik dirençlilikleri belirlenmiştir. Sonuçlara göre 74 adet E.coli suşu tanımlanırken 17 adet K. pneumoniae suşu saptanmıştır. Çalışmamızda izole edilen 74 adet E.coli suşlarında, cefuroxime %88’lik bir oranda direnç tespit edilmiştir. Diğer antibiyotiklere direnç oranını yüksekten düşüğe doğru sıralarsak; amoksisilin/klavulanikasite %79, ampisillin/sulbaktama %67, gentamisine %54, tetrasikline %48, oflaksasine %30, nitrofurantoine %30, streptomisine %23, seftriaksona %20, siproflaksasine %2, sefepime %1 olarak tespit edilmiş ve levoflaksasine direnç tespit edilememiştir.
İzole edilen 17 adet Klebsiella pneumoniae suşlarında ise en yüksek direnç %70’lik bir değerle tetraksikline karşı belirlenmiştir. Diğer antibiyotiklere olan direnç oranını sıralarsak; sefepime %64, gentamisine %59, oflaksine %58, nitrofurantoine %53, siproflaksasine %52, amoksisilin/klavulanik asite %47, ampisillin/sulbaktama %42, streptomisine %35, sefuroksime %30, levofloksasine %29, ve seftriaksona karşı %23’lük bir değerde direnç tespit edilmiştir. Bu bulgular üretimden tüketiciye ulaşıncaya kadar lor peynirlerinin kontaminasyona uğradığını göstermiş ve örneklerden tespit edilen Esherichia coli ve Klebsiella pneumoniae suşlarının antibiyotik dirençliliklerinde artış olduğunu ortaya koymuştur. Bu sonuçlar peynir üretimi, saklanması, antibiotik kullanımının kontrollü olmsının ve satış koşullarının daha iyi şartlarda olması gerektiğini ortaya koymuştur.
Amasya Yöresinde Yetişen Yerel Elma Genotiplerinde Fiziko-Kimyasal Özelliklerin Tespiti
Authors: ÖZMEN Zeliha Selcen , ÇEKİÇ Çetin
Published: June 2021

Bu araştırma, Amasya merkez ve ilçelerinde yetişen yerel elma genotiplerinin pomolojik özelliklerini belirlemek amacıyla 2015-2016 yıllarında yürütülmüştür. Survey çalışmaları sonucunda tespit edilen 24 yerel elma genoptipi incelenmiştir. İncelenen yerel elma genotiplerinde meyve ağırlığı 26,59-273,75 g, meyve eni 37,45-85,77 mm ve meyve boyu 38,18-76,78 mm, meyve eti sertliğinin 14,48-29,00 libre arasında olduğu gözlemlenmiştir. Suda çözünebilir kuru madde (SÇKM) miktarı % 9,2-19,7; pH 4,0-5,2 ve titre edilebilir asit miktarı (malik asit cinsinden) %0,21-1,40 olarak belirlenmiştir. Meyve kabuk rengine ait veriler ise L*, a* ve b* cinsinden kaydedilmiş olup L* değeri 42,31-79,9; a* değeri -21,91-27,47 ve b* değeri 20,79-45,22 arasında bulunmuştur.
Agrega Kil Oranının Betonun Mekanik Özelliklerine Etkilerinin Araştırılması
Authors: GÜRBÜZ Güven , AYDIN Ferhat
Published: June 2021

Agrega içerisinde bulunan farklı oranlardaki kil miktarının betonun mekanik özeliklerini nasıl etkilediğini belirlemek amacıyla bu çalışmada, geleneksel beton üretiminde kullanılan agregalarda bulunan kil içeriğinin beton özellikleri üzerine etkileri deneysel olarak araştırılmıştır. Bu amaçla referans beton numuneleri ile birlikte çeşitli oranlarda ince agrega miktarının %5, %10, %15, %20’si oranında kil ikameli beş seri halinde standart küp ve kiriş numuneler üretilmiştir. Çalışmalar kapsamında, üretilen taze betonlarda (çökme) kıvam, sertleşmiş beton küp numunelerde ise ultrases geçiş hızı ile basınç dayanım deneyleri ve kiriş numunelerde de eğilme deneyleri gerçekleştirilmiştir. Elde edilen deney sonuçlarına göre taze betonda kil oranının artışı ile işlenebilirlik düzeyinin arttığı, sertleşmiş betonda ise kil miktarı arttıkça basınç ve eğilme dayanımlarında büyük oranda azalma olduğu belirlenmiştir. Kil-silt miktarının artmasıyla taze betonda çökme miktarının %43’e varan oranlarda arttığı, basınç dayanımının %39 ve eğilme dayanımın ise %84 oranında azaldığı tespit edilmiş olup ultrases geçiş hızlarının da artan kil oranı ile birlikte azaldığı belirlenmiştir.