bluuebunny/crossref_metadata_2025 huggingface dataset:
A Study on The Relationship Between Organic Agriculture and Agricultural Employment in Türkiye
Authors: Merdan Kurtuluş
Published: July 2024

Organic agriculture is a sustainable agricultural system with different principles that is carried out within the scope of certain rules. Due to the substitution of organic inputs with chemical inputs, getting the products ready for sale, weed control, and similar operations by hand, enterprises engaged in organic farming require a larger labor force. All these jobs increase employment opportunities in rural areas and allow small family businesses to continue production. In this study, it has been tried to reveal the relationship between organic agriculture and agricultural employment with the help of an econometric model and to determine the effect of organic agriculture on employment. The study analyzed a 17-year time series of data spanning from 2004 to 2021 to identify the factors influencing agricultural employment, taking into account various aspects of organic agriculture, including the number of organic agricultural products, the count of farmers engaged in organic agriculture, the area dedicated to organic agricultural production, the organic wild collection area, the total area allocated for organic agricultural production, the quantity of organic agricultural production, the number of entrepreneurs involved in organic agriculture, the unit price of subsidy for organic agriculture, and the total amount of subsidy provided to organic agriculture. Based on the results of the regression analysis, it was determined that the number of organic products does not have a significant effect on agricultural employment. In addition, it was found that the wild harvesting area is positively significant for agricultural employment and that the total production area of organic agriculture and the amount of subsidy are negatively significant. The results of the research reveal that a 1% increase in the wild harvesting area related to organic agriculture would lead to an increase of more than 0.28% in the agricultural employment rate, while a 1% increase in the total production area and the amount of subsidy would lead to a decrease of 0.40% and 0.44% in the agricultural employment rate, respectively.
Examining the Factors Affecting the Use of Crypto Assets as Foreign Payment and Investment Instruments: A Quantitative Study
Authors: Yılmaz Güneş , Koç Tayfur Süleyman
Published: July 2024

The aim of the study is to examine the factors affecting individuals' intentions to use crypto assets as foreign payment and investment instruments. A research model based on the UTAUT-2, a widely accepted model that examines individuals' attitudes toward information technologies, was formed, and the factors affecting two dependent variables, "intention to use in foreign payments" and "intention to invest," were analyzed with PLS-SEM. Path coefficients (β) demonstrated that the variables significantly affecting the intention to use in foreign payments were "performance expectancy," "social influence," and "perceived risk," respectively. Moreover, in order of importance, "performance expectancy," "social influence," "awareness," and "perceived risk" were determined as the variables significantly affecting the intention to invest. Along with path coefficients, f² and q² effect sizes were also analyzed to examine the interaction between the variables. In the context of empirical findings, it was evaluated that the most significant factors in the participants' tendency to use crypto assets in foreign payments and investment transactions were "performance expectancy" and "social influence”. Contrary to the widespread approach in the literature, the study has revealed crucial results for the literature and future studies by addressing the two main financial functions of crypto assets and the factors significantly affecting these functions.
The Relationship Between Electronic Word-of-Mouth Marketing and Consumption Types: The Moderating Role of Income
Authors: Gökerik Mehmet
Published: July 2024

eWOM, a potent communication tool in today's digital age, is extensively utilized by consumers to evaluate products and services, share their experiences, and offer recommendations. Consumers now openly express their opinions about products and services through eWOM on online platforms such as social media, forums, and review websites. Therefore, understanding the impact of eWOM on consumer behaviour holds critical significance in shaping marketing strategies. This article examines how eWOM is specifically associated with conspicuous consumption and symbolic consumption and how these relationships are moderated by income levels.
This study investigated the relationship between electronic word-of-mouth marketing (eWOM) and conspicuous consumption and symbolic consumption while considering the moderating role of income. A survey was conducted among 455 participants in the Karabük province, and the data were analyzed using Amos 20 and SPSS Process 21 software.
The results confirm that eWOM influences both types of consumption. However, the moderating effects of income differ in this context. Income does not play a moderating role in symbolic consumption, meaning that consumers' interest in symbolic products or services remains unaffected by income levels. On the other hand, high-income individuals are observed to pay more attention to eWOM and prefer conspicuous consumption more frequently.
ICT problems of the Azerbaijani language, the Azerbaijani language problems of ICT
Authors: Alguliyev Rasim ,   Institute of Information Technology, Baku, Azerbaijan, Jafarov Yedgar , Aliguliyev Ramiz ,   Institute of Information Technology, Baku, Azerbaijan,   Institute of Information Technology, Baku, Azerbaijan
Published: July 2024

The article is dedicated to the intersection of language and technology, a crucial topic in our contemporary world. The rapid advancements in Information Communication Technologies present both new opportunities and challenges for national languages. As information technologies permeate various aspects of our lives, encompassing communication, the vitality and progression of language occur within this technological landscape. To delve into these dynamics, the article examines the case of the Azerbaijani language. The research is bifurcated into two key areas. The first addresses obstacles hindering the language from fully leveraging Information Communication Technologies capabilities, while the second explores limitations impeding Information Communication Technologies from effectively utilizing the language’s potential. The article provides a thorough analysis of the issues identified in both aspects and proposes solutions to overcome these existing challenges.
O MAPEAMENTO DAS ESCOLAS ESTADUAIS DE CAMPO GRANDE/MS DE 1922 A 1979
Authors: Borges Larsen Kelly Cristiny , Stein Nedina Roseli Martins
Published: July 2024

Este artigo apresenta o mapeamento das escolas estaduais criadas no município de Campo Grande de 1922 até 1979. O ano de 1979 foi utilizado como delimitação, pois foi o ano da divisão do então estado de Mato Grosso, que teve como consequência a criação do estado de Mato Grosso do Sul. O objetivo desta pesquisa foi coletar informações sobre as escolas estaduais criadas em Campo Grande no início do século XX e organizá-las de forma cronológica até a divisão do Estado, a divulgação desse conhecimento objetiva fomentar pesquisas sobre a história dessas instituições e sobre a história da educação da cidade de Campo Grande. A metodologia utilizada foi a pesquisa documental, sobretudo a consulta do banco de dados no site da Secretaria de Educação do Governo do Estado de Mato Grosso do Sul, mais especificamente os Projetos Políticos Pedagógicos das escolas estaduais da cidade de Campo Grande, disponíveis no site. Inicia-se o artigo com um breve contexto histórico da cidade de Campo Grande. A primeira parte contempla o mapeamento de todas as escolas estaduais criadas na cidade de Campo Grande de 1922 até 2018, totalizando setenta e nove escolas. A segunda apresenta algumas informações históricas e singularidades de cada escola, do recorte cronológico estabelecido para este artigo, ou seja, do ano de 1922, data da criação da primeira escola estadual no município, estendendo-se até o ano de 1979, quando é efetivada a divisão do estado de Mato Grosso. As principais referências teóricas foram os autores: Saviani (2008), Sanfelice (2007), Nosella e Buffa (2008).
The Case Law Of The Court Of Justice Of The EU On Art. 17 Of The 1999 Montreal Convention: An Evaluation From A Comparative Perspective
Authors: Chatzipanagiotis Michael
Published: July 2024

This paper analyzes the case law of the Court of Justice of the European Union (CJEU) on Article 17(1) of the 1999 Montreal Convention (MC99) regarding the liability of international air carriers for death or bodily injury to passengers. The interpretational principles and methods applied by the CJEU are examined, accounting also for the particularities of the EU legal order. Furthermore, the results reached by the CJEU are compared with the case law of other jurisdictions, mainly the US, and doctrinal writings. Nonetheless, this paper does not explore the pertinent issues from a de lege ferenda perspective.

The paper concludes that the judgments of the CJEU on Art. 17(1) MC99 have interpreted the notions of “passenger,” “accident,” and “bodily injury” broadly, in a passenger-friendly way. Although the interpretation of ‘passenger’ does not differ from the established case law in other jurisdictions, some aspects of the interpretation of “accident” and the interpretation of “bodily injury” significantly depart from the view currently prevailing among courts internationally. The CJEU has yet to rule on the scope of the exclusivity of the MC99, under Art. 29 thereof, regarding personal injury of passengers. However, the expansive interpretations of “accident” and “bodily injury” by the CJEU limit the practical effect of Article 29 compared to other jurisdictions. Given the regulatory influence that the EU exercises world- wide, the CJEU judgments might guide courts also outside the EU. Although this would bolster passenger protection, it would exacerbate the already fragmented application of the MC99 internationally.
Molecular Docking, Synthesis, Antiproliferative Activity against MCF-7, and In-vitro Alpha Amylase Activities of Newer Generation Pyrimidino Hydroxamic Acid Derivatives
Authors: . Samiya , Saha Supriyo , Jakhmola Vikash , Gairola Nidhi , Singh Mahipal
Published: July 2024

A set of newer generation pyrimidine hydroxamic acid derivatives were designed, synthesized, and evaluated for antiproliferative activity against breast cancer cell line and in-vitro alpha-amylase activity. The design of the molecules was fully dependent upon the structural features of suberoyl anilide hydroxamic acid. Then all the designed molecules (S1-S100) were docked with 4LXZ HDAC2 enzyme and S1, S2, S16 showed good docking interaction scores as compared to SAHA. The interacting residues of (S1, S2, S16) and 4LXZ showed similar amino acid lining as present in the active site. The synthetic procedure of the molecules (S1, S2, S16) was divided into three parts such as synthesis of chalcone derivative using aromatic aldehyde and acetophenone, the reaction between chalcone and thiourea to form substituted pyrimidine-2-thiol, then finally substituted pyrimidine-2-thiol and 2-chloro-N-hydroxyacetamide reacted in the presence of dimethylformamide to obtain the best-docked molecules. All the molecules showed characteristic peaks in fourier-transform infrared (FTIR), proton nuclear magnetic resonance (1H-NMR) and mass spectrometry with sharp melting points and single peak in thin layer chromatography (TLC) plate. Finally antiproliferative activity against MCF-7 and in-vitro alpha amylase activity data confirmed that S1 was the best molecule among all the synthesized molecules.
The Physical Stability of Ciprofloxacin and Levofloxacin Parenteral Dosage Forms in the Polypropylene Plastic Container
Authors: Isadiartuti Dewi , Sari Retno , Retnowati Dini , Gunawan Violyta  Ade , Yanti Risma D , Yudiswara Oki
Published: July 2024

Polypropylene (PP) plastic container is often used as alternatives to glass containers in the primary packaging of parenteral dosage forms, but the usage poses a risk of interaction with the preparations during moist heat sterilization. Therefore, this study aimed to evaluate the physical stability of ciprofloxacin and levofloxacin parenteral dosage forms packaged in PP container after moist heat sterilization. Parenteral preparations were produced by dissolving the active ingredient ciprofloxacin lactate or levofloxacin hemihydrate in water for injection solvent. The solution obtained was then packaged in a 100 mL PP container and subjected to moist heat sterilization at 115°C for 30 minutes. The physical stability of the samples was then tested, including the weight, pH, clarity, number of particles, and sterility. The physical quality parameters before and after sterilization were compared. Data were analyzed using the paired t-test with significance at α 0.05. The results showed that parenteral preparations were sterile and maintained consistent physical stability after being sterilized, except for the number of particles. Furthermore, the number of particles in the sample met the standard requirements. Based on the results, ciprofloxacin or levofloxacin parenteral preparations in PP containers fulfilled the physical stability requirements after moist heat sterilization.
Formulation and Evaluation of Electrospun Nanofiber Mats of Curcumin and Leaf Extract of Tinospora cordifolia: Designed for Accelerating Diabetic Wound Healing
Authors: SB Nagansurkar , Yadav Hemant  KS , Abhay Raizaday
Published: July 2024

Traditional herbs like Tinospora cordifolia and curcumin have many therapeutic benefits. However, curcumin’s limited bioavailability is a problem. Electrospun nanofibers are an answer because they increase the effective surface area greatly, and make drug delivery better in almost all aspects. The combination in the form of nanofibers can be greatly useful in the treatment of diabetic wound healing, where curcumin, the known antibacterial and anti-inflammatory element, plays an important role. It is observed that when combined with extract of leaves of T. cordifolia, which has known antidiabetic and wound healing actions, blended in the chitosan polymer, which is itself a weak antibacterial compound hence can be one of the solutions to the menace of bacterial resistance which is very common in diabetic wound healing. This research aims to create and test electrospun nanofiber mats of curcumin and T. cordifolia leaves extract blended in chitosan as a base polymer in the treatment of diabetic wound healing. Leaves of the plant T. cordifolia, which were collected from the institute’s botanical garden, were subjected to drying and then prone to solvent extraction using methanol and acetone, resulting in the production of bioactive extracts. The curcumin was obtained as a gift sample from Sanjay Chemicals, Mumbai. Nanofibers were electrospun from chitosan, T. cordifolia leaf extract and curcumin. Characterization included scanning electron microscope (SEM), water contact angle measurement, TGA/DSC analysis, drug release studies, fourier-transform infrared (FTIR) analysis, swelling tests and in-vitro release profiling. The nanofiber mats of curcumin and leaves extract of T. cordifolia using chitosan as a base polymer were prepared and evaluated at various parameters. The results we found are very promising. The nanofibers formed by using electrospinning techniques show good content uniformity as well as good diameter which was checked using SEM. The study confirmed no component interactions using differential scanning calorimetry (DSC). The good hydrophilicity of mats was found to ensure good retention time. The study concluded with the formation of a novel formulation that can fight the menace of bacterial resistance, which is very common in the diabetic wound healing process. The formulation will ensure not only countering bacterial resistance but also the faster healing of diabetic wounds, as T. cordifolia leaves extract is known to improve angiogenesis and tissue remodeling.
Calendula Oil Associated Dexibuprofen Nanoformulation Transdermal Patches: Formulation and Characterization
Authors: RS Sharan  Babu , C Sowmya , S Rohith , K Mahalakshmi , K Monisha
Published: July 2024

Objectives: To prepare and characterize the nanoparticle-based topical formulations of dexibuprofen in combination with calendula oil to enhance the topical anti-inflammatory effect. Methods: Chitosan and tri poly phosphate (TPP) were used to prepare nanoparticles developed utilizing the ionotropic gelation technique and analyzed by scanning electron microscope (SEM) and the ZS. Solvent casting was used to prepare the transdermal medication delivery system for the chitosan nanoparticle formulation. Results: Results revealed that nanoparticles were between the sizes of 267.3 nm. This particle size may enhance the drug’s solubility and penetration through the skin. These patches containing chitosan nanoparticles were produced utilizing polymer combinations - HPMC, chitosan, and PEG400 with tween80 as plasticizers. Accompanying the rise in hydrophilic polymer content came an increase in the rate of medication release via the patch. Conclusion: Transdermal patch - F3 released the drug reasonably well.
Design Formulation Ointment and Wound Healing Effectiveness of Onchidiid Slug (Onchidium typhae) Extract Ethanolic Assisted by Design Expert Software
Authors: Wijianto Bambang , Pratiwi Liza
Published: July 2024

Research on onchidiid slugs has been conducted regarding their antibacterial activity and wound healing abilities. Objective: This study aims to design the ointment formula as an effective drug delivery base for wound healing. The formula design was obtained using the mixture design method using Design Expert software version 13.0. The proposed and optimum formulas were then evaluated for their physical properties (organoleptic, homogeneity, spreadability, adhesion, and pH). The incision wound was made with a wound length of 1.5 cm with a depth of 0.2 cm on the mouse’s back. The assay group was divided into several groups. Group I is the positive control treated with betadine ointment. Group II is the negative control treated with an ointment base without active extract. Group III is the group given crude extract. Groups IV, V, and VI are the treatment groups’ optimum formula of onchidiid slug ethanol extract ointment: 1, 3, and 5%, respectively. The intervention for each group was carried out for ten days with smearing once a day. The design results in optimal formulas with the composition of adeps lanae and vaseline album (9,566:70, 344) with a desirability value of 0.934. Tests for adhesion power, spreadability, and optimum formula pH meet the requirements for a good ointment. An ointment containing 1% onchidiid slug extract showed the best wound-healing effectiveness. This formula is 88.31% effective in wound healing. Onchidiid slug ethanol extract can be designed into an effective ointment for wound healing assisted by the mixture design method using Design Expert software.
Formulation and Evaluation of Immediate Release Tablets of Antimalarial Drug Hydroxychloroquine
Authors: Gaikwad Dushyant , Dhainje Priyanka , Kadam Sachin , Tare Harshal
Published: July 2024

The goal of the study was to develop and evaluate an immediate-release antimalarial tablet formulation for the effective management of malaria, an antimalarial drug as an active pharmaceutical ingredient using excipients. Appropriate pharmaceutical products and evaluate their properties in relation to the innovative product. The study was to develop an antimalarial formulation with in-vitro solubility properties equivalent to or better than the improved formulation. Therefore, an orally administered immediate-release tablet with a robust and reproducible formulation technique was developed. According to the study, the number of F3 definitions decreased the most and F8 had the most important medicinal properties. At 20 minutes, F4 appeared to lead the first high decay rate (98. 56%), followed closely by F5 (93.48%). The expansion of F1, F2 and F3 shows high decay rates at this time. Based on this information, one can analyze and compare the decay profiles of unmistakable definitions. Things such as composition, excipients used, and manufacturing geometry can influence degradation behavior, and this information may be necessary to optimize concentrations of substances of interest for drug delivery. It is then concluded that the definition number F5 may be an optimized detail.
The Development of an Innovative Ophthalmic In-situ Gel Containing Posaconazole
Authors: ST Kumbhar , MA Salunke , PT Mane , BS Wakure
Published: July 2024

The goal of this study was to create and test various in-situ gel formulas for administering posaconazole to the eye to treat fungal keratitis. They used an in-situ gelling method to help posaconazole stay in the eye mucosa longer, which made it easier for the body to use. To make in-situ gel preparations, polymers such as sodium alginate, poloxamer 407, and poloxamer 188 were used in a cold method. Finally, there was 0.2% (w/w) posaconazole in the mixtures. The pH, drug content, viscosity, gelling capacity, and temperature at which the solution turns into a gel were all checked on the recipes. It was between 32 and 34℃ when each blend turned into a gel. There was about the same amount of drugs in all of them. It was also worked out how much of the antifungal and in-vitro drugs these mixtures would release. Everyone in the drug release study showed signs of long-lasting release. To sum up, in-situ gels that contain posaconazole could be a good way to use optical drug delivery to change how fungus diseases act.
Development and Characterization of Olmesartan Medoxomil-Loaded Microspheres for Hypertension Management
Authors: Mali Dipak , Bandgar Sandip , Bandgar Indrayani , Gaikwad Dinanath
Published: July 2024

Our aim is to develop and assess microspheres loaded with olmesartan medoxomil, the antagonist of angiotensin II receptor which is used in hypertension treatment, for their efficacy. The microspheres were fabricated through a solvent evaporation process employing eudragit L100 and chitosan as the inner phase and liquid paraffin as the outer phase. Optimization was done according to the results of entrapment efficiency and in-vitro drug release. Fourier-transform infrared (FTIR) analysis indicated negligible interaction, which clarifies the suitability of the drug and excipients. The resulting microspheres exhibited a pale yellow hue and free-flowing characteristics, as confirmed by micromeritics experiments. Scanning electron microscopy (SEM) revealed smooth and spherical microspheres. Particle size, ranging from 187.44 to 358.75 μm, increased with polymer concentration, as determined by optical microscopy. Formulation F9, with a ratio of eudragit L100 to chitosan at 7:1, demonstrated the highest drug entrapment percentage (97.82%). In-vitro release studies demonstrated a reduction in olmesartan medoxomil release with increasing polymer content, with formulation F9 sustaining release for 12 hours. Furthermore, short-term accelerated stability testing indicated the physicochemical stability of the microsphere formulations throughout the stability period.
Kinetics Aspects in Design and Release of Nasal Drug Delivery Systems
Authors: Choudante Shubham , Deshmukh Priya , Kadam Vaishali , Tare Harshal
Published: July 2024

The traditional school of Indian medicine includes a sort of nasal therapy known as Nasya karma. There is a lot of recent interest in using the nasal route for administering difficult medications including tiny polar compounds, vaccines, hormones, peptides, and proteins. Nasal drug molecules are highly suited for systemic distribution and the absence of hepatic first-pass metabolism. Vaccination through the nose is thought to be a straightforward and economical method with improved patient compliance, and it may also provide immunity at numerous distant mucosal locations. Microparticle, nanoparticle, and liposomal nasal vaccination delivery technologies are now in development and show protection in animal models. Both pharmacokinetics & pharmacodynamics of nasal administration devices have been studied in-vivo by a number of different research organizations. The purpose of this review was to summarise these studies and bring attention to the work done on nasal-based formulations to better treat conditions like epilepsy, schizophrenia, and neurodegenerative diseases.
RP-HPLC Method for Estimation of Caspofungin in Bulk and in Parenteral Dosage Form
Authors: Kadam Sachin , Bhosale Ganesh , Jorvekar Ankita , Tare Harshal
Published: July 2024

In order to more precisely and accurately estimate the antifungal medicine caspofungin and its parenteral dosage form, a new, straightforward, and cost-effective reverse-phase high-performance liquid chromatography (RP-HPLC) technique has been created. The accuracy, precision, linearity, specificity, and reproducibility of the method for the measurement of caspofungin in used equipment were determined during the present study’s validation according to the International Council of Harmonization (ICH) criteria. Elution was accomplished using a CHEMSIL ODS-C18 (5μm) column in isocratic mode with a mobile phase consisting of acetonitrile:ammonium acetate buffer at pH 4.8 (60:40%v/v). The mobile phase was pumped into the column at a flow rate of 1.0 mL/min, and the eluent was detected using a variable wavelength UV detector set at 210 nm. The column dimensions are 250 × 4.6 mm. The chromatogram for the optimized RP-HPLC method of caspofungin estimation had 28,99 theoretical plates (N) and a strong peak at a resolution time of 16,105 minutes. The thorough validation process led to the conclusion that the approach is stable and could be applied for the duration of the drug’s shelf life.
Artificial Intelligence Could be the Personalized Treatment Strategy for Cancer
Authors: Ugemuge Pooja K , Khandalkar Gaurav G , Ingle Rahul G
Published: July 2024

Cancer is one of the world’s most serious medical challenges. Because of its great heterogeneity, persons with similar tumors could react in a different way to the same drugs or surgical methods, prompting the development of more accurate tumor treatment approaches as well as patient-specific tailored treatments. To establish targeted therapy choices for patients, it is critical to have a full acceptance of the changes that tumors endure, counting modifications in their genetic factors, proteins, and cancer cell behaviors. Tumor treatment requires precise targeting. Big data-driven artificial intelligence (AI) may reveal patterns, insights, and related information hidden inside huge volumes of data. To identify exact data from transcriptomics, radiomics, genomes, proteomics, digital pathological images, etc., subsets of AI’s machine learning capability may be explored. This may help clinicians get a better and more comprehensive knowledge of malignancies. In addition, to provides the optimal therapy for each patient and improves clinical outcomes.
Cognitive Factors Leading to Human Error: A Major Contributing Factor for Quality Deviations in Pharmaceutical Industry
Authors: Moorkoth Sudheer , Nayak Ranjani , B N Srinivasa , Kunkalienkar Shivani
Published: July 2024

The pharmaceutical sector is one of the top research-based sectors in the world which continuously produces new medications that improve and save human lives. Patients, as well as healthcare professionals depend on pharmaceutical companies for the treatment of ailments, so it is very important to develop a good quality product following Good manufacturing practices guidelines that ensure the quality, safety, and efficacy of the product. Human cognitive errors are a major cause of quality deviations. These quality deviations result in product recalls, a ban on products by regulators where the company’s reputation will be tarnished which can result in loss of sales and revenue. Human errors can be identified and mitigated by various techniques. In this paper, we discuss the factors contributing to cognitive errors, the impact of cognitive errors on the pharmaceutical industry, the identification of the cognitive errors causing current good manufacturing practices (cGMP) deviations, and challenges in the mitigation of cognitive errors. A survey questionnaire and the form human error assessment and reduction technique (HEART) tool were also developed and discussed in the manuscript.
Revolutionizing Wound Healing: The Rise of Electrospinning Nanofibers for Bioactive Dressings
Authors: Panda Jajnadatta , Pal Abhisek , Panda Pritipadma , Panigrahy Archana
Published: July 2024

A noticeable focus in recent years has been on creating bioactive dressings that are tailored to meet the requirements of wounds that are both acute and chronic. Because of these exceptional properties, electrospinning nanofibers stand out as a potential choice among the creative solutions being investigated. Among these are very high porosity and superior permeability to water and air, both of which are essential for promoting wound healing conditions. Moreover, these nanofibers’ ability to ward against foreign infections makes them an attractive option for improving wound care protocols. It is particularly notable because they closely mimic the extracellular matrix since this property can greatly enhance the efficacy of skin regeneration and wound healing processes. The present study aimed to explore the use of electrospinning nanofibers for bioactive dressings and wound healing. Extensive literature search was performed and relevant articles were collected from various databases like Google scholar, Taylor and Francis, Science direct, Springer, Embase, and Willey. Electrospinning nanofiber applications for the bioactive healing of wounds. The investigation begins with a comprehensive review of the wound healing procedure and the several electrospinning techniques used here. The many natural and synthetic polymers that are used to make electrospinning wound dressings are discussed in more detail. Prominent natural polymers, including hyaluronic acid, collagen, gelatin, silk fibroin, chitosan, and sodium alginate, are emphasized due to their special qualities and possible advantages in wound treatment. Furthermore, the paper explores the wide application of artificial polymers such as polyvinyl alcohol, polyvinyl chloride, polyethylene lactone, polylactide, and polyurethane, providing insight into their roles in the advancement of sophisticated wound dressings. In conclusion, the development of electrospinning technology offers promising prospects for creating improved wound care products and dressings that have the potential to completely transform the wound management industry.
Mass Spectrometric Identification of Urinary Biomarkers of Chronic Kidney Disease: A Proteomic-Related Preliminary Report
Authors: Kademani Sangeetha P. , Nelaturi Prabhudas , Kalidas Sathya Sagar , Ballambattu Vishnu Bhat , Sambandam Ravikumar
Published: July 2024

Background

Chronic kidney disease (CKD) is a gradual loss of kidney function and has an increased prevalence rate worldwide. Our study was intended to identify potential biomarkers of progression using urine proteomics.

Materials and Methods

This preliminary study consisted of 32 patients with stage V CKD. Urine samples were subjected to liquid chromatography–mass spectrometry (LCMS), and the network of protein interaction was analyzed using STRING.

Results

A total of 135 proteins were identified, of which 35 were listed as candidates based on their clinical significance. Protein– protein interaction study provides novel insights into the functional constitution of the proteome, selecting urine as a source of biomarkers.

Conclusion

The present study observed that the potential markers such as EndoG, HPX, APN, AnxA1, Mic60, LONP1, and HYOU1 correlate with renal damage and its progression to CKD stage V.
Tunneled Dialysis Catheter Insertion in External Jugular Vein by Nephrologists
Authors: Behera Vineet , Ahmad Shahbaj , Sinha Smriti , Reddy G Gireesh , Srikanth K , Ghosh Indranil , Chauhan Prabhat , Ramamoorthy Ananthakrishnan , Hande Vivek
Published: July 2024

Background

External jugular vein (EJV) is used to insert tunneled dialysis catheter (TDC) in patients with no AVF and exhausted right internal jugular veins (IJV). There is scarce data on TDC insertion in EJV by nephrologists with fluoroscopy guidance.

Materials and Methods

This was a prospective observational study that included hemodialysis patients with exhausted right IJV access who underwent EJV TDC insertion, and excluded occluded ipsilateral brachiocephalic vein or superior vena cava, EJV < 5 mm diameter, or patients with existing EJV TDC. All patients underwent evaluation of central veins. TDC insertions were performed by a nephrologist using ultrasound and fluoroscopic guidance. The primary outcome was the successful insertion of EJV TDC and catheter removal within 6 months due to major catheter dysfunction or complications.

Results

EJV TDC was successfully inserted in 23/23 cases (100% success), of which 17 (73.9%) were in right side, and 21 (91.3%) were denovo insertions. Catheter dysfunction needing removal occurred in seven cases (30.4%) with subclavian vein thrombosis in five cases (21.7%) and infectious complications in two cases (8.6%). The censored catheter survival was 23/23 (100%) at 1 month, 22/23 (95.6%) at 3 months, and 13/20 (65%) at 6 months. Cases of EJV catheter removal had a significant association with drainage of EJV into subclavian vein as compared to other anatomical variants (p = 0.005).

Conclusion

EJV TDC insertion has a good technical success rate when performed under fluoroscopy. It is associated with an acceptable rate of catheter dysfunction, especially thrombosis, which is more common in EJV opening into subclavian veins.
Articular cartilage regeneration: A current concepts review
Authors: Vaish Abhishek , Vaishya Raju
Published: July 2024

Articular cartilage injuries and defects have limited or no repair capacity. Most of the current surgical techniques can produce only fibrocartilage and not the actual hyaline cartilage. This review explores current trends in articular cartilage treatment, focusing on established approaches, emerging therapies, and future directions. A detailed literature search was performed on PubMed, Scopus, Embase, and Google Scholar in May 2024. All the relevant studies were identified and included in this review. While surgical techniques are crucial, non-operative approaches such as physical therapy with targeted mechanical stimulation or pulsed electromagnetic fields, the use of biomarkers for early diagnosis and treatment, and monitoring play a key role in managing symptoms and supporting the regeneration process. Over the past few decades, various surgical techniques have been developed for treating articular cartilage defects more effectively. Despite the field of cartilage regeneration making significant strides, there are still several key research gaps that need to be addressed. The future of cartilage regeneration is brimming with exciting possibilities such as bioprinting, bioengineering, stem cell therapies, gene editing, and the use of artificial intelligence. Many promising techniques show success in pre-clinical studies but translating them into effective and safe clinical treatments requires further research and large-scale clinical trials. Careful consideration of the ethical implications of using these therapies remains paramount. Hence, cartilage regeneration research is a field brimming with potential. While challenges remain, such as optimizing cell delivery and ensuring the long-term functionality of regenerated tissue, the future looks promising.
ПОДХОДЫ К ИСКУССТВЕННОМУ ВОСПРОИЗВОДСТВУ КУМЖИ (SALMO TRUTTA LABRAX PALLAS, 1814) В АЗОВО-ЧЕРНОМОРСКОМ БАССЕЙНЕ
Authors: Михайлов А.В. , Шульгина Е.В.
Published: July 2024

В данной статье рассматриваются вопросы обеспечения населения продукцией рыболовства и аквакультуры. Указано на возрастающую роль искусственного воспроизводства водных биологических ресурсов в мире. Отмечена высокая значимость лососевых рыб на рынке Российской Федерации. Описан дисбаланс распределения продукции лососевых рыб и сложность логистики между местом основного потребления продукции в Европейской части страны и регионом её производства на Дальнем Востоке. Указано на ограничения по возможности выращивания лососевых видов рыб на северо-западе России и на постоянное присутствие импорта компенсирующего локальный дефицит лососевых рыб. Отмечено, что Азово-Черноморский бассейн не задействован отечественной рыбной промышленностью для производства лососевых рыб несмотря на удачный опыт сопредельных стран и близость рынка сбыта. В качестве перспективного объекта воспроизводства в Азово-Черноморском бассейне указана черноморская кумжа Salmo trutta labrax (Pallas, 1814). Рассматривается современное состояние популяции кумжи в бассейнах Черного и Азовского морей и проблемы воспроизводства вида. Предложено два подхода для увеличения численности кумжи. Первый более консервативен, базируется на улучшении условий естественного воспроизводства, второй направлен на увеличение численности вида за счет искусственного воспроизводства с последующим выпуском в естественную среду обитания.
ПОВЫШЕНИЕ ЭФФЕКТИВНОСТИ ЭНЕРГООБЕСПЕЧЕНИЯ ПРЕДПРИЯТИЯ ПРИБОРОСТРОИТЕЛЬНОЙ ПРОМЫШЛЕННОСТИ
Authors: Любова Т.С. , Галковский В.А.
Published: July 2024

В статье предлагается вариант повышение эффективности энергообеспечения промышленного предприятия путем отказа от централизованного энергообеспечения в пользу перехода на собственные источники тепловой и электрической энергии. На примере предприятия приборостроительной промышленности, для покрытия необходимых для эффективного производства энергетических нагрузок, рассматривается возможность использования одноконтурной парогазовой установки. Представлены две принципиальные тепловые схемы парогазовой установки, отличающиеся уровнем эффективности энергообеспечения, режимами работы, эффективностью использования топлива и компоновкой оборудования, указаны их достоинства и недостатки. Приведены преимущества, получаемые предприятием при использовании собственного источника энергии.
О ВЗАИМОСВЯЗИ ДНЕВНОГО СВЕТА И ЦИРКАДИАННЫХ РИТМОВ
Authors: Болдырева Ю.В. , Губин Д.Г. , Ананьев В.Н.
Published: July 2024

В статье описана роль солнечного света и циркадианных ритмов. Показано, что основная роль солнечного света заключается в том, что он является мощным источником естественного дневного света, который способен координировать работу органов и систем организма в единое целое.
ВЛИЯНИЕ ФИЗИОЛОГИЧЕСКИХ ВОЗМОЖНОСТЕЙ СУГГЕСТИИ В ВИДЕ ДОМИНАНТЫ А.А. УХТОМСКОГО НА ФИЗИЧЕСКУЮ РАБОТОСПОСОБНОСТЬ ЮНОШЕЙ С КАРИЕСОМ ЗУБОВ
Authors: Прокопьев Н.Я. , Осипов А.С. , Ананьев В.Н. , Ананьева О.В. , Гуртовой Е.С.
Published: July 2024

В статье даётся анализ влияния суггестии в виде доминанты академика А.А. Ухтомского на уровень физической работоспособности (ФР) и максимального потребления кислорода (МПК) по степ тесту В.Л. Карпмана у 24 юношей 19,9 ± 1,6 лет, болеющих кариесом зубов. На момент обследования юноши входили в 1 и 2 группы здоровья и не имели соматических заболеваний. Показано, что суггестия в виде доминанты Ухтомского достоверно (p<0,05) повышает ФР юношей, но практически не влияет на МПК.
ОЦЕНКА СЕЗОННОЙ ИЗМЕНЧИВОСТИ СОДЕРЖАНИЯ СОЕДИНЕНИЙ ТЯЖЕЛЫХ МЕТАЛЛОВ В ВОДАХ ВЕРХНЕГО ТЕЧЕНИЯ РЕКИ УРАЛ
Authors: Хисаметдинова А.Ю. , Бускунова Г.Г. , Янтурин С.И.
Published: July 2024

В статье представлены результаты сезонной изменчивости содержания тяжелых металлов (Cu, Zn, Fe, Mn) в водах реки Урал и ее притоков. Исследованные участки реки характеризовались разным уровнем химического загрязнения, где наблюдалась значительная сезонная изменчивость: значения концентраций в осенний период значительно выше, чем весной, за исключением соединений железа.
STUDY OF THE CONCEPT OF "PRODUCTION STRATEGY" IN THE CIRCULAR ECONOMY
Authors: Джандарова Л.Х.
Published: July 2024

Статья посвящена исследованию понятия «производственная стратегия», предложенных различными учеными. С помощью метода сравне- ния выделены схожие и отличительные черты приведенных трактовок. Акту- альность исследования сущности «производственной стратегии» обусловле- на динамическими и критическими изменениями внешней среды, требующих принятия кардинальных мер по адаптации производственного потенциала предприятия к потребностям и возможностям общества. По результатам исследований определены предпосылки и основные принципы, которые влияют на производственную стратегию современных предприятий и, соот- ветственно, определяют содержание этого понятия. Уточнено понятие «про- изводственная стратегия» в соответствии с особенностями функционирова- ния современных предприятий и тенденциями развития мировой экономики.
Bar coding technology as a way to increase the competitiveness of an organization
Authors: ЕЛИСЕЕВ Г.Г. , ЛУКАШОВА О.А. , ШТАНЬКО Н.А.
Published: July 2024

В работе рассмотрены технологии штрихового кодирования, как одного из способа повышения конкурентоспособности организации. Высокий уровень конкуренции на рынке логистических услуг обуславливает необходимость внедрения инновационных технологий с применением штрихового кодирования. Данные технологии необходимы для предоставления качественных и безопасных услуг потребителям. В работе пред-ставлены исследования компаний, применяющих в своей деятельности технологии штрихового кодирования.
The role of youth in the development of rural cooperation
Authors: Головина С.Г. , Ручкин А.В. , Абилова Е.В.
Published: July 2024

В последние годы наблюдается повышенный интерес не только к тому, как кооперативы решают различные экономические, социальные и экологические проблемы села, но и как они становятся особым инструментом в руках молодых людей, улучшая условия их занятости, способствуя профессиональному становлению, расширяя доступ к предпринимательству и инновациям. Как показало исследование, в контексте развития новых технологий, изменения отраслевых тенденций, переориентации общества на социальные и экологические цели (особенно в свете угроз биологического, климатического и геополитического характера) молодёжь играет важную роль в развитии кооперации, так как именно она является активной частью общества, готовой к участию в различных экосистемных проектах и инициативах. Обзорно-теоретический анализ и социологический опрос, предпринятые в ходе работы, в очередной раз подтвердили, что, с одной стороны, молодые люди обладают существенным потенциалом и присущей им энергией, которые могут быть использованы для реализации кооперативами своей многофункциональной миссии, с другой стороны, сами кооперативы (с их особым организационным устройством и целеполаганием) способны создать благоприятную среду для активного участия молодёжи в их функционировании. Важно отметить, что всё это происходит на фоне существенных изменений в деятельности самих кооперативов, организационное устройство и модели функционирования которых значительно трансформируются в настоящее время. Основная задача исследования, в связи с этим, состоит в том, чтобы специфицировать (1) тенденции развития кооперации в условиях новых вызовов и угроз, (2) возможности молодёжи продвигать предпринимательство и инновационную деятельность в целом, без чего динамичное (успешное, конкурентоспособное) развитие кооперативов невозможно, (3) потенциал кооперативных организаций в создании ключевых для жизнедеятельности молодого поколения условий (образование, занятость, предпринимательство и др.), а также важных для общества ценностей, таких как солидарность, взаимопомощь, равенство, вовлечённость в хозяйственную деятельность. В итоге, верифицированный в работе научный постулат сводится к тому, что кооперация в сельской местности обладает широким спектром опций в решении важных для молодых людей экономических, социальных и экологических проблем, касающихся получения образования и профессиональной подготовки, обеспечения достойной работой и занятостью, вовлечения в местное управление и включения в сложившиеся социальные сети. Молодёжь, в свою очередь, вносит в кооперативную деятельность креативность, инновационность и адаптивность, что придаёт сельским кооперативам экономическую устойчивость и социальную значимость.
Prospects for the implementation of neural networks and artificial intelligence in industrial production Sopina Natalya Vladimirovna
Authors: Сопина Н.В. , Маккаева Р.С.
Published: July 2024

татья "Перспективы внедрения нейросетей и искусственного интеллекта на промышленном производстве" исследует роль нейросетей и искусственного интеллекта в современной промышленности и их потенциал для оптимизации производственных процессов. Внедрение нейросетей и искусственного интеллекта на промышленных предприятиях открывает перспективы для значительного улучшения производительности, эффективности и конкурентоспособности. Основные преимущества внедрения нейросетей и искусственного интеллекта включают повышение эффективности производственных процессов, снижение издержек и улучшение качества продукции. Нейросети и искусственный интеллект находят применение в контроле и управлении производственными процессами, прогнозировании спроса и управлении цепями поставок, оптимизации производственных операций, контроле качества продукции и автоматизации производственных задач. Однако, внедрение нейросетей и искусственного интеллекта также сталкивается с вызовами и препятствиями, включая недостаток квалифицированных специалистов, вопросы конфиденциальности данных и сложности интеграции существующих систем. Несмотря на это, справляясь с вызовами и преодолевая препятствия, предприятия смогут воспользоваться преимуществами нейросетей и искусственного интеллекта. Будущее внедрения нейросетей и искусственного интеллекта на промышленных предприятиях обещает развитие технологий, сотрудничество между искусственным интеллектом и людьми и дальнейшее улучшение производственных процессов. Применение инновационных технологий, таких как распределенные системы и облачные вычисления, также будет способствовать эффективной работе предприятий и повышению производительности.
ANALYSIS OF THE IMPACT OF INFORMATION TECHNOLOGY ON INFORMATION MANAGEMENT
Authors: Абдулаева С.И. , Чажаева М.М. , Шахбанова З.И.
Published: July 2024

В современном мире информационные технологии быстро развиваются, и развитие информационных технологий сформировало еди- ный глобальный рынок, что создало жесткую рыночную конкуренцию по все- му миру, и в этой конкуренции необходимо побеждать. Необходимо следить за быстрым прогрессом науки и техники, основной производительной силы. Новая ситуация выдвинула новые требования к развитию и обновлению ме- тодов и концепций управления. Исходя из этого в данной статье представ- лены основные характеристики современных информационных технологий, такие как значительное улучшение количества и качества скорости передачи информации, сосуществование информационного взрыва и дефицита ин- формации и т.д. На этом основании в статье также кратко перечисляются функции управления информацией в условиях современных информацион- ных технологий: возможности и вызовы; основные стратегии управления ин- формацией в текущей ситуации, а также некоторого понимания конструкции информационной модернизации нашей страны.