bluuebunny/crossref_metadata_2025 huggingface dataset:
The Role of Genistein in Mammalian Reproduction
Authors: Guelfi Gabriella , Pasquariello Rolando , Anipchenko Polina , Capaccia Camilla , Pennarossa Georgia , Brevini Tiziana A. L. , Gandolfi Fulvio , Zerani Massimo , Maranesi Margherita
Published: November 2023

Genistein is a natural compound belonging to flavonoids, having antioxidant, anti-inflammatory, and anti-neoplastic properties. Genistein is considered a phytoestrogen. As such, genistein can bind estrogen receptors (ERα and ERβ), although with a lower affinity than that of estradiol. Despite considerable work, the effects of genistein are not well established yet. This review aims to clarify the role of genistein on female and male reproductive functions in mammals. In females, at a high dose, genistein diminishes the ovarian activity regulating several pathway molecules, such as topoisomerase isoform I and II, protein tyrosine kinases (v-src, Mek-4, ABL, PKC, Syk, EGFR, FGFR), ABC, CFTR, Glut1, Glut4, 5α-reductase, PPAR-γ, mitogen-activated protein kinase A, protein histidine kinase, and recently circulating RNA-miRNA. The effect of genistein on pregnancy is still controversial. In males, genistein exerts an estrogenic effect by inducing testosterone biosynthesis. The interaction of genistein with both natural and synthetic endocrine disruptors has a negative effect on testis function. The positive effect of genistein on sperm quality is still in debate. In conclusion, genistein has a potentially beneficial effect on the mechanisms regulating the reproduction of females and males. However, this is dependent on the dose, the species, the route, and the time of administration.
Hybrid Zn-β-Aminoporphyrin–Carbon Nanotubes: Pyrrolidine and Direct Covalent Linkage Recognition, and Multiple-Photo Response
Authors: Rebelo Susana L. H. , Laia César A. T. , Szefczyk Monika , Guedes Alexandra , Silva Ana M. G. , Freire Cristina
Published: November 2023

To unveil and shape the molecular connectivity in (metallo)porphyrin–carbon nanotube hybrids are of main relevance for the multiple medicinal, photoelectronic, catalytic, and photocatalytic applications of these materials. Multi-walled carbon nanotubes (MWCNTs) were modified through 1,3-dipolar cycloaddition reactions with azomethine ylides generated in situ and carrying pentafluorophenyl groups, followed by immobilization of the β-amino-tetraphenylporphyrinate Zn(II). The functionalities were confirmed via XPS and FTIR, whereas Raman spectroscopy showed disruptions on the graphitic carbon nanotube surface upon both steps. The functionalization extension, measured via TGA mass loss and corroborated via XPS, was 0.2 mmol·g−1. Photophysical studies attest to the presence of the different porphyrin–carbon nanotube connectivity in the nanohybrid. Significantly different emission spectra and fluorescence anisotropy of 0.15–0.3 were observed upon variation of excitation wavelength. Vis-NIR absorption and flash photolysis experiments showed energy/charge transfer in the photoactivated nanohybrid. Moreover, evidence was found for direct reaction of amino groups with a carbon nanotube surface in the presence of molecular dipoles such as the zwitterionic sarcosine amino acid.
Reducing In-Hospital and 60-Day Mortality in Critically Ill Patients after Surgery with Strict Nutritional Supplementation: A Prospective, Single-Labeled, Randomized Controlled Trial
Authors: Im Kyoung Moo , Kim Eun Young
Published: November 2023

Malnutrition in critically ill patients is a global concern, especially those who undergo abdominal surgery, as it is associated to higher infectious complications, prolonged hospital stays, and increased morbidity. Despite the importance of proper nutrition, guidelines remain broad, and practical implementation is often inadequate. We aimed to assess the effects of strict nutritional provision and investigate the appropriate target for nutrition support. A prospective, randomized controlled trial was conducted in critically ill patients admitted to intensive care units following abdominal surgery. The intervention group received targeted protein and calories, with consultation from a nutritional support team upon admission. In total, 181 patients in the intervention and 144 in the control group were analyzed. The intervention group demonstrated improved nutrition provision and subsequently better clinical outcomes, including a reduced 60-day mortality (4.4 versus 15.3, p = 0.001), postoperative complications (24.9 versus 47.2, p < 0.001), and in-hospital mortality (5 versus 17.4, p < 0.001). High modified nutrition risk in the critically ill scores [odds ratio (OR) = 2.658, 95% CI = 1.498–4.716] were associated with increased 60-day mortality, while active nutritional intervention (OR = 0.312, 95% CI = 0.111–0.873) was associated with lower mortality rates. Notably, the provision of targeted energy and protein alone did not exhibit a significant association with mortality outcomes.
Multi-Omics Data Integration Reveals Sex-Dependent Hippocampal Programming by Maternal High-Fat Diet during Lactation in Adult Mouse Offspring
Authors: Gauvrit Thibaut , Benderradji Hamza , Pelletier Alexandre , Aboulouard Soulaimane , Faivre Emilie , Carvalho Kévin , Deleau Aude , Vallez Emmanuelle , Launay Agathe , Bogdanova Anna , Besegher Mélanie , Le Gras Stéphanie , Tailleux Anne , Salzet Michel , Buée Luc , Delahaye Fabien , Blum David , Vieau Didier
Published: November 2023

Early-life exposure to high-fat diets (HF) can program metabolic and cognitive alterations in adult offspring. Although the hippocampus plays a crucial role in memory and metabolic homeostasis, few studies have reported the impact of maternal HF on this structure. We assessed the effects of maternal HF during lactation on physiological, metabolic, and cognitive parameters in young adult offspring mice. To identify early-programming mechanisms in the hippocampus, we developed a multi-omics strategy in male and female offspring. Maternal HF induced a transient increased body weight at weaning, and a mild glucose intolerance only in 3-month-old male mice with no change in plasma metabolic parameters in adult male and female offspring. Behavioral alterations revealed by a Barnes maze test were observed both in 6-month-old male and female mice. The multi-omics strategy unveiled sex-specific transcriptomic and proteomic modifications in the hippocampus of adult offspring. These studies that were confirmed by regulon analysis show that, although genes whose expression was modified by maternal HF were different between sexes, the main pathways affected were similar with mitochondria and synapses as main hippocampal targets of maternal HF. The effects of maternal HF reported here may help to better characterize sex-dependent molecular pathways involved in cognitive disorders and neurodegenerative diseases.
The Development of Text Messages to Support People at Risk of Diabetes in Low-Resourced Communities: The South African Diabetes Prevention Programme
Authors: Hill Jillian , Faber Mieke , George Cindy , Peer Nasheeta , Mulabisano Tshavhuyo , Mostert Sonja , Sobngwi Eugene , Kengne Andre
Published: November 2023

Emerging evidence suggests that the addition of text messages to standard healthy lifestyle interventions may improve the outcomes of diabetes prevention programs (DPP). This paper describes the process of developing text messages targeting behavior change in people at risk of developing diabetes in low-resourced communities as part of the South African DPP (SA-DPP). The development comprised multiple steps led by nutrition and physical activity experts. The steps included the following: (1) text message development based on the existing SA-DPP curriculum and its formative research; (2) text message evaluation for readability/understandability in terms of content, language, and quality, with 75 participants from two low-resourced areas in Cape Town; (3) text message refinement by the expert panel; (4) evaluation of the refined text messages by participants from Step 2; and (5) text bank finalization. Based on the readability survey, 37 of the 67 formulated text messages [24 of the 44 encouraged healthy eating, and 13 of the 23 promoted physical activity] were refined. Based on focused discussions with participants, seven more messages were refined to consider alternative terminology. The final text bank includes a total of 67 messages comprising topics related to fruit and vegetable consumption as well as the importance of having variety in the diet (n = 15), limiting fat intake (n = 10), avoiding sugar (n = 11), avoiding salt (n = 5), promoting fiber-rich foods (n = 1), messages promoting physical activity (n = 21), and general check-in messages (n = 4). Most of the text messages were acceptable, understandable, and largely feasible to all participants, with some of the nutrition-related messages being less feasible for participants due to their socioeconomic position. The next step is to assess the text messages in the SA-DPP intervention trial.
FODMAPs—Unknowns for Consumers: First Survey in Serbia
Authors: Torbica Aleksandra , Vujasinović Vesna , Radosavljević Miloš , Radivojević Goran , Milovanović Ilija
Published: November 2023

According to unofficial data, every fifth person in Serbia suffers from some form of irritable bowel syndrome (IBS). Compounds classified as FODMAPs (Fermentable Oligo-, Di-, and Monosaccharides and Polyols) are newly found potential triggers of IBS and a number of associated gastrointestinal disorders. Cereals, predominantly in their wholegrain form, represent the key contributors to the high contents of FODMAPs in wholegrain (high-fiber) bakery products. The current work was structured in a way to systematically evaluate the consumer’s knowledge and preferences toward wholegrain and low-FODMAP bakery products. The questionnaire was filled out by 725 respondents, aged from 18 to 86 years. They were informed about the aim of the research and management of anonymous data. The present study is the first detailed survey in this region of Europe, aiming to improve the familiarity with and attitude toward FODMAPs and a low-FODMAP diet by analyzing the different dietary habits regarding wholegrain-cereal-based products among consumers of various ages, genders, places of residence, and education. The results suggest that the respondents are, to some degree, aware of the health benefits of consuming foods with high fiber content while indicating a low level of knowledge about FODMAP compounds and connected topics. Education about contemporary scientific findings and the potentially harmful effects of consuming FODMAP compounds for a population with gastrointestinal disorders and diseases will be imperative in the future.
Genital Infection Caused by Salmonella enterica Serovar Hvittingfoss: A Case Report
Authors: De Hert Emilie , Baïli Sarah , Vanden Driessche Marleen , Jansens Hilde , Vandamme Sarah , Jacquemyn Yves , Vodolazkaia Alexandra , Mukovnikova Marina , Mattheus Wesley , Matheeussen Veerle
Published: November 2023

Background: Nontyphoidal Salmonella serovars predominantly cause gastrointestinal infections. However, other clinical presentations, including urogenital infections, have been reported, although they are rather rare. Case presentation: This case is about a 33-year-old woman diagnosed with Salmonella enterica serovar Hvittingfoss (S. Hvittingfoss) bacteremia and endometritis six days post uterine aspiration in the context of a missed abortion. She had traveled to Indonesia two weeks prior to the positive blood and cervical culture. She never developed gastrointestinal symptoms but was found to carry S. Hvittingfoss in her stool sample. The patient was successfully treated with a seven-day course of iv ciprofloxacin. Conclusions: S. Hvittingfoss is a rare serovar that has caused a few outbreaks of foodborne infections in Asia, the United States, and Australia. To the best of our knowledge, this is the first reported case of Salmonella urogenital infection caused by this serovar. Salmonella as a cause of urogenital infections is rare but not uncommon. Therefore, it should be considered in identifying members of the Enterobacterales among urogenital flora in cases of severe urogenital infections, especially when other cultures remain negative.
Pathomorphological Findings and Infectious Diseases in Selected European Brown Hare (Lepus europaeus Pallas, 1778) Populations from Schleswig-Holstein, Germany
Authors: Faehndrich Marcus , Woelfing Benno , Klink Jana C. , Roller Marco , Baumgärtner Wolfgang , Wohlsein Peter , Raue Katharina , Strube Christina , Ewers Christa , Prenger-Berninghoff Ellen , Verspohl Jutta , Lavazza Antonio , Capucci Lorenzo , Tomaso Herbert , Siebert Ursula
Published: November 2023

In the northernmost German federal state Schleswig-Holstein, populations of European brown hares (Lepus europaeus Pallas, 1778) show diverse densities and varying courses over the years. To examine differences in pathomorphological findings and infectious diseases as possible reasons for varying population dynamics, we assessed 155 hunted hares from three locations in Schleswig-Holstein from 2016 to 2020. We investigated the association of location, year, age, and sex of animals to certain pathomorphological findings and infectious diseases. Frequent pathomorphological findings were intestinal parasites (63.9%), hepatitis (55.5%), nephritis (31.0%), steatitis (23.2%), enteritis (13.5%), and pneumonia (5.2%). Body condition differed significantly between locations, and the prevalence of pneumonia was significantly higher in females. Enteritis was not detected in 2019, when much more juveniles were sampled. Hepatitis and nephritis occurred significantly more often in 2016 and among adults. Additionally, more adults showed hepatitis with concurrent serotitre for European brown hare syndrome virus (EBHSV), while intestinal parasitosis as well as high excretion rates of coccidia were more common in juveniles. Sampled animals showed high infection rates with Eimeria spp. (96.1%), Trichostrongylus spp. (52.0%), Graphidium strigosum (41.2%), and a high seroprevalence (90.9%) for EBHSV, without severe symptoms. This study revealed a low prevalence of infectious pathogens, but a high prevalence of chronic inflammations of unknown origin in the tested brown hare populations. Overall, our results indicate a rather minor importance of infectious diseases for observed population dynamics of analysed hare populations in Schleswig-Holstein.
Impact of Equine and Camel Piroplasmosis in Egypt: How Much Do We Know about the Current Situation?
Authors: Elsawy Bassma S. M. , Mahmoud Mona S. , Suarez Carlos E. , Alzan Heba F.
Published: November 2023

Piroplasmosis is a global tick-borne disease caused by hemoprotozoan parasites, which causes high morbidity and substantial economic losses in farm animals. Equine and camel piroplasmosis causes significant losses worldwide and in Egypt. The multifactorial effects and overall impact of equine and camel piroplasmosis in Egypt remain poorly characterized. However, several Babesia and Theileria spp. as well as potential tick vectors affecting these two species have been identified in the country. Equine and camel piroplasmosis has been reported by all governates in the country. Thus, in this work, we intend to provide a broad depiction of the current approaches used for diagnosis and control and the impact of piroplasmosis on the equine and camel industries in Egypt. We also identified current gaps in knowledge that might help develop future research efforts towards improved intervention and control of equine and camel piroplasmosis. It is important to develop specific diagnostic tools suitable for the early and chronic diagnosis of this disease. Altogether, the current situation warrants the development of large-scale epidemiological studies in order to obtain an accurate estimate for equine and camel piroplasmosis to secure the highly needed food resources in the country.
Cysteamine Eye Drops in Hyaluronic Acid Packaged in Innovative Single-Dose Systems, Part II: Long-Term Stability and Clinical Ocular Biopermanence
Authors: Castro-Balado Ana , Cuartero-Martínez Andrea , Pena-Verdeal Hugo , Hermelo-Vidal Gonzalo , Schmidt Anja , Montero Belén , Hernández-Blanco Manuela , Zarra-Ferro Irene , González-Barcia Miguel , Mondelo-García Cristina , Giráldez María Jesús , Yebra-Pimentel Eva , Otero-Espinar Francisco J. , Fernández-Ferreiro Anxo
Published: November 2023

Background: Cystinosis is a rare genetic disorder characterized by the accumulation of cystine crystals in several tissues and organs causing, among others, severe eye symptoms. The high instability of cysteamine eye drops makes it difficult to develop formulations with an acceptable shelf life to be prepared in hospital pharmacy departments. Previously, a new compounded formulation of cysteamine eye drops in hyaluronic acid (HA) packaged in innovative single-dose systems was developed. Methods: Long-term stability at −20 °C of this formulation was studied considering the content of cysteamine, pH, osmolality, viscosity, and microbiological analysis. The oxygen permeability of single-dose containers was also studied and an ocular biopermanence study was conducted in healthy volunteers measuring lacrimal stability and volume parameters. Results: Data confirm that cysteamine concentration remained above 90% for 120 days, all parameters remaining within the accepted range for ophthalmic formulations. The permeability of the containers was reduced over time, while ocular biopermanence was maintained despite the freezing process and storage time. Conclusions: 0.55% cysteamine hydrochloride formulation in HA and packaged in single-dose containers preserved at −20 °C is stable for 120 days protected from light, presenting high potential for its translation into clinical practice when commercial presentations are not available.
Active Contraction in the Stable Mechanical Environment of the Tunic of the Ascidian, Halocynthia roretzi, a Polysaccharide-Based Tissue with Blood Circulatory System
Authors: Kato Yoko
Published: November 2023

Halocynthia roretzi, a member of Ascidiacea, is covered with its own tunic, which is composed of polysaccharides, such as cellulose Iβ and sulfated chitin. H. roretzi has an open-vessel system, whose blood vessels and hemocytes are found in the tunic, so that the mechanical environment of the tunic could be carefully controlled because of its influence on hemocyte behaviors. While active deformation of the tunic and related phenomena have been previously reported, the mechanical environment in the tunic, which directly influences its deformation, has been rarely investigated. Meanwhile, the developments of actuators based on cellulose and chitin have been frequently reported. However, a cellulose–sulfated chitin actuator has not been proposed. In this study, the mechanical environment of the tunic, which has been rarely investigated despite its importance in the active deformation of the tunic, was evaluated using finite element analysis. A finite element model of the tunic, based on its histological characteristics as well as deformation patterns, was developed. The results showed that the shape of the tunic, the pattern of fiber distribution, and control of the water content influenced the mechanical environment.
Mining and Analysis of Production Characteristics Data of Tight Gas Reservoirs
Authors: Liu Baolei , Li Changxuan
Published: November 2023

The production characteristics of gas reservoirs are one of the important research subjects in gas reservoir development. To better guide the production development and strategy formulation of tight gas reservoirs, it is necessary to utilize data mining techniques to clarify the production characteristics of different reserves types of tight gas reservoirs. The production varies with the size of the recoverable reserves. In this study, 261 tight gas reservoirs worldwide were divided into three categories based on the size of their recoverable reserves. By considering the complete lifecycle of tight gas reservoirs, the production variations were classified into 16 production features, and these features were compiled into a dataset. Three algorithms, namely random forest, LightGBM, and CatBoost, were trained separately to analyze the relationship between the production characteristics and the size of the recoverable reserves of tight gas reservoirs. The objective was to define the production characteristics of tight gas reservoirs with different reserve sizes. Consequently, a set of production characteristic judgment rules that align with the size of the recoverable reserves of tight gas reservoirs was established. The findings revealed that LightGBM provided accurate predictions for the development characteristics of tight gas reservoirs with different reserve sizes. The production characteristics of large-scale tight gas reservoirs are as follows: the cumulative production at the end of the production increase phase ranges from 10 to 115.8 billion cubic meters, while the cumulative production at the end of the stable production phase ranges from 7.9 to 154.9 billion cubic meters. The peak production ranges from 2.3 to 3.8 billion cubic meters, and the decline period is estimated to last between 40 to 51 years. For medium-scale tight gas reservoirs, the production characteristics are as follows: the cumulative production at the end of the production increase phase ranges from 2.5 to 10 billion cubic meters, while the cumulative production at the end of the stable production phase ranges from 2.4 to 7.9 billion cubic meters. The peak production ranges from 0.8 to 2.3 billion cubic meters, and the decline period ranges from 20 to 40 years. As for small-scale tight gas reservoirs, the production characteristics are as follows: the cumulative production at the end of the production increase phase ranges from 0.1 to 2.5 billion cubic meters, while the cumulative production at the end of the stable production phase ranges from 0.2 to 2.4 billion cubic meters. The peak production ranges from 0.005 to 0.8 billion cubic meters, and the decline period ranges from 3 to 20 years. This study can provide potential references for the formulation of development technology policies for tight gas reservoirs and the assessment of reservoir production potential.
Semantic Segmentation of Urban Airborne LiDAR Point Clouds Based on Fusion Attention Mechanism and Multi-Scale Features
Authors: Wang Jingxue , Li Huan , Xu Zhenghui , Xie Xiao
Published: November 2023

Semantic segmentation of point clouds provided by airborne LiDAR survey in urban scenes is a great challenge. This is due to the fact that point clouds at boundaries of different types of objects are easy to be mixed and have geometric spatial similarity. In addition, the 3D descriptions of the same type of objects have different scales. To address above problems, a fusion attention convolutional network (SMAnet) was proposed in this study. The fusion attention module includes a self-attention module (SAM) and multi-head attention module (MAM). The SAM can capture feature information according to correlation of adjacent point cloud and it can distinguish the mixed point clouds with similar geometric features effectively. The MAM strengthens connections among point clouds according to different subspace features, which is beneficial for distinguishing point clouds at different scales. In feature extraction, lightweight multi-scale feature extraction layers are used to effectively utilize local information of different neighbor fields. Additionally, in order to solve the feature externalization problem and expand the network receptive field, the SoftMax-stochastic pooling (SSP) algorithm is proposed to extract global features. The ISPRS 3D Semantic Labeling Contest dataset was chosen in this study for point cloud segmentation experimentation. Results showed that the overall accuracy and average F1-score of SMAnet reach 85.7% and 75.1%, respectively. It is therefore superior to common algorithms at present. The proposed model also achieved good results on the GML(B) dataset, which proves that the model has good generalization ability.
An Intelligent Evaluation Method for Service Safety of Cable Net Structures under Multiple Factors
Authors: Liu Zhansheng , Zhang Zehua , Yuan Chao
Published: November 2023

Various uncertainties often influence the serviceability of cable net structures, which can impact their structural safety performance. The accurate identification of sensitive factors during the structure’s service life and the determination of its serviceability state is crucial for achieving intelligent serviceability safety. In this paper, based on the digital twin model, a multi-factor-based assessment method for the serviceability safety of cable net structures was proposed. Firstly, the assessment method for serviceability safety under multi-factor influence was described in detail, outlining the specific workflow. Secondly, key indicators that affect the structural safety state are selected, and their range of variation is determined. Subsequently, a comprehensive dataset of sample data, considering long-term multi-factor influence, was constructed, through combined simulation using MATLAB 2021 and ANSYS 15.0. Finally, a support-vector-regression-based structural safety assessment model was established and validated.
Sosyal Bilgiler Öğretmen Adaylarının Pandemi Kavramına Yönelik Metaforik Algıları
Authors: AVCU Kübra Melis , ÇAKAR ÇELİK Özlem
Published: November 2023

İnsanoğlu tarih boyunca birçok kez salgın hastalıklarla karşılaşmış, ağır kayıplar vermiştir. Akademik literatürde beşerî afetler içerisinde değerlendirilen salgın hastalıkların en belirgin özelliği hastalığın türü, ortaya çıkış-yayılış şekli ve zamanın değişkenlik göstermesine rağmen yeniden görülme özelliğinin daima var olmasıdır. Nitekim salgın hastalıklar 21. yüzyılda dünyanın gündemine tekrar oturmuş, ekonomik, sosyal, kültürel vb. birçok açıdan insanlığı derinden etkilemiştir. Dünya Sağlık Örgütü 11 Mart 2020 tarihinde salgını pandemi olarak duyurmuştur. Bu nedenle pandemi kavramı günlük hayatın içerisine doğrudan yerleşmiş, eğitim düzeyi, yaş aralığı, cinsiyet, meslek türü fark etmeksizin insanlar tarafından bilinir hale gelmiştir. Ancak salgının psiko-sosyal, sosyo-ekonomik, sosyo-kültürel etkileriyle nedeniyle pandemi kavramı birçok insan için farklı anlam taşımaktadır. Bu çalışmada geleceğin öğretmenleri olarak sosyal bilgiler öğretmen adaylarının pandemi kavramına ilişkin metaforik algılarının belirlenmesi amaçlanmıştır. Nitel türde olgubilim deseniyle yürütülen bu çalışmada katılımcıları 2021-2022 eğitim öğretim yılı güz dönemi Fırat Üniversitesi Eğitim Fakültesi Sosyal Bilgiler Eğitimi Anabilim Dalının lisans programının bütün sınıf düzeylerinde öğrenim gören toplamda 200 öğrenci oluşturmuştur. Çalışma sonucunda pandemi kavramına ilişkin olarak katılımcılar tarafından 129 metafor geliştirilmiştir. Tespit edilen bu metaforlar “kısıtlama”, “psikolojik ve ruhsal etki”, “belirsizlik”, “yayılma”, “hakimiyet ve etkisi altına alma”, “ekonomik etki”, “sosyal yaşam ve insan ilişkileri”, “bilinçli olma”,” ve “dinlenme” olmak üzere 9 kavramsal kategoride değerlendirilmiştir.
Ortaokul Öğrencilerinin Konuşma Kusurlarının Öğretmen Görüşlerine Göre İncelenmesi
Authors: AKÜZÜM Cemal , AKÜZÜM Leyla , ERDEM Muzaffer , TEKİN Tacer , AKÜZÜM Zülfü
Published: November 2023

Araştırmanın amacı, ortaokullarda öğrenim görmekte olan öğrencilerin akademik gelişimlerini ve sosyal hayatlarını etkileyen konuşma becerisi kazandırılması sürecinde gözlemlenen konuşma kusurlarını öğretmen görüşlerine göre incelemektir. Araştırma, nitel araştırma yaklaşımı çerçevesinde yarı yapılandırılmış görüşme tekniği ile gerçekleştirilmiştir. Araştırmanın çalışma grubunu, 2021-2022 öğretim yılında Güneydoğu Anadolu Bölgesi’ndeki bir ilimizin merkezinde bulunan ortaokullarda görev yapan 10 Türkçe öğretmeni oluşturmaktadır. Araştırmada veri toplama aracı olarak 7 maddelik yarı yapılandırılmış görüşme formu kullanılmıştır. Verilerin analizinde, içerik analizi tekniği kullanılmıştır. Araştırma bulguları; sınav kaygısı yüzünden test ağırlıklı çalışan çocuğun konuşmaya ve yazmaya gerektiği kadar zaman ayıramadığını, öğretmenlerin öğrencilerinin konuşma becerisi geliştirebilmeleri için derslerinde sesli öykü ve şiir okutma etkinlikleri yaptırdıklarını, öğrencilerinde söz hakkını beklememe, yöresel ağız kullanma ve kelime hazinesinin yetersizliği gibi konuşma kusurları gözlemlediklerini, akademik başarının konuşma becerisinden etkilendiğini ve konuşma sıkıntısı yaşayan öğrencilerin sosyal becerileri sergilemede yetersizlik yaşadıklarını ortaya koymaktadır.
Penentuan Sifat Fisik Biji Kakao Varietas Klon 45 dan Sulawesi 01 di Kabupaten Bolaang Mongondow Utara
Authors: Timumu Febrianti , Longdong Ireine A. , Lengkey Lady Ch. C. E.
Published: November 2023

Tujuan penelitian adalah untuk menentukan dimensi biji kakao (panjang, lebar, tebal) serta diameter rata-rata aritmatik, geometri, spherisitas, porositas, densitas kamba, sudut curah dan sudut gesek dari varietas Klon 45 dan Sulawesi 01. Metode yang digunakan dalam penelitian ini adalah metode ekperimen, dianalisis secara deskriptif. Hasil penelitian menunjukkan bahwa rata-rata biji kakao varietas Klon 45 panjang 27.25 mm, lebar 14.35 mm, tebal 7.25 mm, aritmatik 16.28 mm, geometri 14.03 mm, spherisitas 0.52. Varietas Sulawesi 01 memiliki ukuran  panjang yaitu 20.44 mm, lebar 12.29 mm tebal 7.52 mm aritmatik 13.46 mm geometri 12.32 mm spherisitas 0.60. Varietas klon 45 memiliki porositas 30.62%, densitas kamba 0.44 g/ml, berat 100 biji 95.39 g. Varietas Sulawesi 01 memiliki porositas 29.62%, densitas kamba 0.51 g/ml, berat 100 biji 144.72 g. Sudut curah varietas Klon 45 sebesar 29.96º pada kadar air 9.19%  dan varietas Sulawesi 01 sebesar 23.07º pada kadar air 7.57%. Sudut gesek varietas Klon 45 sebesar 29.94º pada kadar air 9.19% dan Sulawesi 01 sebesar 25.03º pada kadar air 7.57%.

Kata kunci: biji kakao, sifat fisik, varietas.
Karakteristik Fisikokimia dan Organoleptik Biskuit dengan Pencampuran Tepung Ubi Jalar Ungu (Ipomoea Batatas) dan Tepung Ampas Kelapa
Authors: Muchtar Husnul Khatimah , Koapaha Teltje , Oessoe Yoakhim
Published: November 2023

Tujuan penelitian ini adalah mengetahui karakterisitik fisikokimia dan sensoris pada biskuit dengan pencampuran tepung ubi jalar ungu dan tepung ampas kelapa. Metode penelitian yang digunakan rancangan  acak  lengkap  (ral) terdiri dari 5 perlakuan dengan pencampuran tepung terigu,tepung ubi jalar ungu dan tepung ampas kelapa yaitu A: (100%:0%:0%), B: (30%: 30%:40), C: (30%: 40%:30%), D: (30%:50%:20%) dan E: (30%: 60%:10%). Hasil penelitian menghasilkan karakteristik fisikokimia biskuit yaitu kadar air berkisar antara 2.37% - 5.75%,  kadar abu 2.15% - 3.29% , kadar lemak 25.03%- 31.05% , kadar protein 5.76%- 7.20% , kadar  karbohidrat 54.51%- 60.33% , serat kasar 1.54%- 4.36% , kalori 493.55-525.47 Kkal dan daya kekerasan 579.78- 893.80 g.sec. Uji sensoris biskuit yang paling disukai yaitu perlakuan D dengan pencampuran 30% tepung terigu: 50% tepung ubi jalar ungu :20% tepung ampas kelapa dengan nilai rasa 4.73 (agak suka), warna 5,77 (suka), aroma 5,67 (suka) dan tekstur 5,7 (suka).

Kata kunci: biskuit, tepung ubi jalar ungu, tepung ampas kelapa.
Effect Of Blanching on The Physicochemical Characteristic of Leilem Leaves (Clerodendrum Minahassae Teisjm. & Binn).
Authors: Kusmin Gloria , Sumual Maria F. , Lalujan Lana E.
Published: November 2023

Leilem leaves are vegetables that have a short shelf life, so they require postharvest handling to maintain the quality and quantity of leilem leaves. Blanching can be done as an effort to handle postharvest vegetables which can extend the shelf life of vegetables by heating methods. This research was conducted to determine the effect of blanching time on the quality and nutritional value of leilem leaves. The study was based on the RAL method with 5 treatments namely K0 (without blanching), K1 (1 minute blanching), K2 (3 min blanching), K3 (5 min blanching), K4 (7 min blanching) at 85°C which included a test color (hunter method), water content (AOAC method), chlorophyll content (Wintermans & de Mots method), vitamin C content and antioxidant activity using the spectrophotometer method.

The results showed that there was an effect of the dip blanching treatment on vegetable color, chlorophyll levels, vitamin C levels and antioxidant activity. Blanching at 85°C for 3 minutes increased the water content, chlorophyll content and antioxidant activity, but not vitamin C. A longer blanching time of more than 3 minutes could cause degradation and decomposition of the chlorophyll content and antioxidant activity of leilem leaves.

Keywords: Blanching, Leilem leaves, Color, Chlorphyl, Vitamin C, Antioxidants and Moisture Content
Aktivitas Antioksidan Yoghurt Sinbiotik Berbasis Daging Kelapa Muda (Cocos nucifera L.) dan Ubi Jalar Ungu (Ipomoea batatas L)
Authors: Siswandi Winie Vania Tasya , Djarkasi Gregoria Sri Suhartati , Ludong Maya M. , Tuju Thelma D. J. , Taroreh Mercy I. R. , Nurali Erny J. N.
Published: November 2023

Yoghurt sinbiotik merupakan minuman berbentuk cair semi kental yang mengandung prebiotik dan probiotik. Tujuan penelitian yaitu menganalisis sifat fisik dan kimia, mengukur aktivitas antioksidan, serta mengetahui tingkat kesukaan terhadap warna, rasa, aroma dan tekstur yoghurt sinbiotik berbasis daging kelapa muda dan ubi jalar ungu. Metode yang digunakan adalah metode Rancangan Acak Lengkap (RAL) dengan perlakuan penambahan bubur ubi jalar ungu (0%, 5%, 10%, 15%, 20%, 25%). Hasil penelitian yoghurt sinbiotik berbasis daging kelapa muda dan ubi jalar ungu memiliki rata-rata viskositas 10,27 cP-10,90 cP, pH 3,86 – 4,01, total padatan terlarut 7,83Brix-8,17Brix, total asam 0,84%-0,98%, warna 4,47-5,93 (netral-sangat suka), rasa 4,30-5,00 (netral-suka), aroma 4,70-5,33 (suka)  dan tekstur 4,63-5,47 (suka) dan aktivitas antioksidan pada perlakuan P5 (25% bubur ubi jalar ungu) persen inhibisi 86,88% dan IC50 80,73 ppm (kuat).
The Analysis of Bacteriological Quality (E.coli and Coliform) of refill drinking water in Lolak, Bolaang Mongondow Regency.
Authors: Bandu Arafah , Tuju Thelma D. J , Assa Jan R.
Published: November 2023

This research uses descriptive analysis method in order to know the content of microorganisms E.coli and Coliform in refill drinking water at several refill drinking water depots in Lolak sub-district, Bolaang Mongondow regency. The results of the study on the analysis of E. coli microorganisms from eight water samples tested, namely D1, D2, E1, E2, F1, F2, G1, G2 all met the requirements determined by the Indonesian National Standard (SNI) and PERMENKES No. 492 of 2010. While in terms of the Coliform test, it is found that there is only one sample of water that is not fit for consumption, which is in the sample code G2 where the amount of Coliform contained in it exceeds the amount determined by the Indonesian National Standard (SNI) while the other samples, with sample codes D1, D2, E1, E2, F1, F2, G1 meet the requirements of the Indonesian National Standard (SNI) for consumption.

Keywords: refill drinking water; E.coli; Coliform.
Corporate Governance Practices and Performance of Deposit Taking Sacco's in Nairobi City County Kenya
Authors: Kihara Boniface , Bett Shadrack
Published: November 2023

Good performance of SACCOs is a key ingredient for its continuous existence and sustainability. The financial intermediation function carried out by SACCOs is dependent on how well they perform. Over the years, there have been various concerns by policy makers and academician over the SACCOs' dismal performance in Kenya. Despite the various corporate governance initiatives and measures implemented by important organizations such as the Centre for Company Governance, the issue of firm corporate governance remains unresolved, despite the involvement of the Capital Markets Authority and SASRA. The aim of this research is to determine how the performance of deposit taking SACCOs in Nairobi is influenced by corporate governance. The research focused on how stakeholder involvement, board composition, organizational structure, and control environment affect Nairobi-based deposit-taking SACCOs’ performance. The study's base was stakeholder, agency, stewardship, and resource dependence theory. The study employed a descriptive design. A census approach was used whereby all the deposit taking SACCOs in Nairobi were included in the study. The target population was 47 CEOs, 47 Sacco officers, 47 heads of finance and 47 heads of credit department. Data was gathered using structured questionnaire. In this research, to evaluate the construct and content validity, the researcher did a pilot test. Both descriptive and multiple regression analysis were used to examine the data. The findings showed that corporate governance factors (board composition, organization structure, control environment and stakeholder involvement) had a correlation coefficient (R) of 0.691 with an R squared of 0.477. From the ANOVA table corporate governance had a significant effect on performance of DT Saccos (F=28.513; p= 0.000). From the regression, corporate governance (board composition, organization structure, control environment and stakeholder involvement) had a positive effect on performance of DT Saccos. This study concludes that corporate governance (board composition, organization structure, control environment and stakeholder involvement) has a positive effect on performance of DT Saccos in Nairobi, Kenya. The study recommends that management of DT Saccos improve their corporate governance for increased performance levels. There is need for similar research based on other factors influencing performance, other measures of the variables, other Saccos & institutions as well as adopting secondary data.
Synthesis and characterization of α-Fe2O3 Nanoparticles and α-Fe2O3 /TiO2 Nanocomposite and application them in a solar cell
Authors: Abd Ganm , Amer Musa Juda
Published: November 2023

Abstract:

     Nanostructures of metal oxides of TiO2 and α-Fe2O3 are prepared through the hydrothermal method. Also α-Fe2O3/TiO2nanocomposites are prepared by the hydrothermal technique using an and α-Fe2O3 /TiO2 nanocomposites are mixed in the equal ratio. The properties of the prepared compounds are investigated through Field Emission Scanning Electron Microscopy (FE-SEM), Transmission Electron Microscopy (TEM), X-Ray Diffraction (XRD).  The optical properties of prepared compounds are studied through UV-Vis Spectroscopy, X-ray diffraction patterns of prepared TiO2, and α-Fe2O3 have shown a( monoclinic structure, Tetragonal, and Hexagonal ) respectively. The optical band gap is (3.0, 1.6 and 2.7) eV for TiO2, α-Fe2O3 NPs and CuO/TiO2/α-Fe2O3nanocomposites. Dye-sensitized solar cells (DSSCs) fabricated based on TiO2, α-Fe2O3 NPs and α-Fe2O3 /TiO2/ nanocomposites are casted onto (FTO) substrates (front electrode). while the back electrode is a carbon/FTO-glass substrate. Two natural dyes of dyes are used green leek dye and red pomegranate dye whereas iodine/ iodide (KI/I2) is used as the electrolyte solution.. The solar cells efficiency rates (0.65, 1.38 and 0.96) for TiO2, α-Fe2O3 Nps and α-Fe2O3 /TiO2/ nanocomposites/re d pomegranate dye respectively. and The solar cells' efficiency rates are (0.69, 1.93 and1.29) for TiO2, and α-Fe2O3 /TiO2/ nanocomposites/ green leek dye respectively
Adsorption Study of Ni (II) and Pb (II) by Silver oxide Nanoparticles
Authors: E. Sultan Alaa , Hussein I.Abdullah  , Abdul qadier H. Niama
Published: November 2023

In the present work, silver oxide nanoparticles (Ag2O-NPs) were used as an adsorption surface for removing nickel and lead ions from aqueous solutions, the surface properties were studied using various techniques like Fourier-transform infrared spectroscopy (FTIR) spectra shown the functional groups present in the synthesis silver oxides nanoparticles, X-ray diffraction (XRD) confirmed the crystalline nature of Ag2O-NPs with a crystallite size 38.69 nm, field emission scanning-electron-microscopy(FE-SEM) images showed that the Ag2O-NPs has spherical shape, and the presence of elemental silver signals of the silver oxide nanoparticles was confirmed by energy dispersive x-ray (EDX) analysis spectrum.Adsorption experiments were carried out in order to determine the effect of contact time, adsorbent dose, and temperature on adsorption capacity, as well as to track the removal of Ni (II) and Pb(II) by Ag2O nanoparticles. Experiments showed that 50 min was a good choice as the ideal contact time to remove Ni (II) and Pb(II) ions, the optimal quantity of adsorption is approximately 200 (mg/l), and the optimal temperature that can be used to remove Ni(II) and Pb(II) ions is 298K. The results showed that both Ag(I) and Ni(II) could be effectively removed from aqueous solutions.
Determination of Malondialdehyde (MDA) and Some Antioxidant Activities in Rheumatoid arthritis Patients
Authors: Elham Abdulqadir Abdulrahman1  , Halit Demir2  , Bakhtyar Kamal Aziz3
Published: November 2023

Background: Muscle weakness is a common comorbidity of several severe diseases which results in a reduced independence and quality of life and for the afflicted patients. Patients with rheumatoid arthritis (RA), a disease characterized by a chronic inflammation of the joints, commonly report of muscle weakness as a complication. Muscle weakness is the result of reduced muscle size and intramuscular impairments (i.e., intrinsic muscle dysfunction).
Influence of LGALS3 Gene Polymorphism as A Potential Predictor for Cardiopathy Complication of Type 2 Diabetes Mellitus
Authors: Rasha Hasan Jasim  , Sara Sattar Jabbar
Published: November 2023

Galectin-3(Gal-3) belongs to lectins family binding β-galactoside that have at least one of the carbohydrate recognition domains (CRDs) in their own structure, which located on chromosome 14 (14q22.3).Gal-3Plays an important role in modulating cardiac inflammation and fibrosis. Therefore, LGALS3 gene, encoding galectin-3 protein, which considered promising candidate for the genetic study of cardiovascular diseases (CVDs),and evaluating the association between LGALS3 gene polymorphisms and the susceptibility and prognosis of myocardial infarction(MI) .Gal-is a pleiotropic molecule expressed on the cell membrane, within the cytoplasm or the nucleus. It has been proposed to function as a mediator of inflammation, fibrosis, cell adhesion, apoptosis, and chemotaxis. It is highly expressed in macrophages within and atherosclerotic plaques.galectin-3 can mediate production of profibrotic factors and collagen accumulation in a variety of diseases. The role of galectIn-3 in regulating macrophage invasion and consequent modulation of atherosclerotic plaque phenotype. Finally, the current study concluded that the amount of LGALS-3 gene expression is related to rs4652 SNP variant in patients with MI due toT2D complications.
Biochemical Study For Evaluation of some Clinical Parameters as Predictors of Myocardial Infarction in Patients With Type 2 Diabetes Mellitus Undergoing Elective Percutaneous Coronary Intervention
Authors: Rasha Hasan Jasim  , Sara Sattar Jabbar
Published: November 2023

When blood  flow to the heart muscle is impeded, fat and cholesterol build up on the inner wall of the heart, causing coronary heart disease (CHD), myocardial infarction (MI), and sudden cardiac death are just a few of the diseases that can occur in CAD as a result of atherosclerosis. A catheter is used during Percutaneous Coronary Intervention (PCI), also known as angioplasty, a non-surgical procedure to squeeze a balloon or stent into a narrowing area to restore blood flow to the myocardium. Therefore, it is treated with medication to widen or open up the veins in the heart muscle that contain plaque accumulation that results in stenosis in order to avoid the coronary artery blockage from occurring again. The key CVD risk factor is lipid profile and some biochemicals parameters, and each kind these parameters are associated with an increase in the incidence of MI. Anabolic processes, energy metabolism, and blood sugar levels are all controlled by the hormone insulin. Glycosylated hemoglobin (HbA1c) is frequently used to measure the average blood glucose levels of a person based on the age. The resulting values also help to diagnose diabetes mellitus by determining the blood sugar level. Elevated aminotransferase levels indicating liver function, have attracted great concern as potential novel markers of cardiovascular risk assessment. Although blood urea nitrogen (BUN), creatinine (Cr), and electrolytes is not the mainstay of diagnosis in MI patients, they may have a role in providing a more detailed view of the complications and mortality rates.
Evaluasi Kinerja Komisi Pemberantasan Korupsi Dalam Pemberantasan Korupsi
Authors: Firdaus Ahmad Hanif
Published: November 2023

Korupsi merupakan masalah serius dalam berbagai sektor pemerintahan dan bisnis, merugikan negara dan masyarakat secara luas. Komisi Pemberantasan Korupsi (KPK) di Indonesia dibentuk sebagai lembaga independen untuk memerangi korupsi. Tujuan penelitian ini adalah untuk mengevaluasi kinerja KPK dalam pemberantasan korupsi di Indonesia. Penelitian ini menggunakan metode penelitian kualitatif. Teknik pengumpulan data pada penelitian ini yakni dengan studi kepustakaan dengan mengeksplorasi buku, jurnal, dan informasi lain yang relevan degan penelitian. Data yang telah terkumpul kemudian dianalisis melalui tiga tahapan yakni reduksi data, penyajian data dan penarikan kesimpulan. Hasil penelitian menunjukan bahwa evaluasi terhadap kinerja KPK menunjukkan bahwa tingkat korupsi masih tinggi, dan beberapa berpendapat menyatakan bahwa pengawasan pidana korupsi sebaiknya dikembalikan kepada Polri atau Jaksa. Selain itu, KPK masih dianggap belum mencapai kinerja yang memuaskan.
Efektivitas Antosianin Ekstrak Bunga Mawar Untuk Pengobatan Diabetes Mellitus Tipe 2
Authors: Kurniawan Wawan , Patonah Patonah
Published: November 2023

Hiperglikemia adalah suatu kondisi medis berupa peningkatan kadar glukosa darah melebihi normal yang menjadi karakteristik beberapa penyakit terutama diabetes melitus di samping berbagai kondisi lainnya. Kekayaan bunga-bunga tropis di Indonesia yang dapat dimakan telah menjadi bagian dari kuliner nusantara, secara tradisional digunakan sebagai obat, sebagai pewarna alami untuk makanan dan minuman. Antosianin merupakan senyawa turunan polifenol yang keberadaannya sangat melimpah di alam dengan keanekaragaman dalam berbagai jenis tumbuhan. Antosianin adalah komponen alami yang terakumulasi pada vakuola dan bertanggungjawab untuk warna merah, biru dan ungu pada buah, sayur, bunga dan tumbuhan lainnya. Berbagai manfaat positif dari antosianin untuk kesehatan manusia adalah sebagai antioksidan, meningkatkan kemampuan penglihatan mata, anti inflamasi, mencegah diabetes, menghambat sel tumor dan mencegah penyakit neurologis.
ENSINO INDIVIDUALIZADO: ADAPTAR O ENSINO DE ACORDO COM AS NECESSIDADES INDIVIDUAIS DE CADA ALUNO, OFERECENDO INSTRUÇÕES CLARAS, ORGANIZAÇÃO E ESTRUTURAÇÃO DAS TAREFAS, E FEEDBACK ESPECÍFICO E IMEDIATO.
Authors: Dias Renan Italo Rodrigues , Andrade Roseli Pereira , Neves Ogaciano dos Santos , Santos Denilson de Souza , Bastos Adriana Regina da Silva , Jesus Bruna Rodrigues Martins de , Rocha Maria Eduarda de Sá Bonifácio , Borges Danielle Dantas , Vieira Francisca de soisa , Correia Catia Arantes , Costa Matheus Gomes da , Lins Adriana Vieira
Published: November 2023

O ensino individualizado refere-se à prática educacional de personalizar o processo de ensino de acordo com as necessidades e características individuais de cada aluno. Isso inclui fornecer instruções claras e precisas, estabelecer uma estrutura organizacional para as tarefas, bem como oferecer feedback específico e imediato para promover o desenvolvimento e o aprendizado. Essa abordagem visa atender às diferentes habilidades, interesses e estilos de aprendizagem de cada aluno, proporcionando um ambiente de aprendizagem adaptável e flexível. Ao reconhecer as diferenças individuais, os educadores podem ajustar o conteúdo e as estratégias de ensino para maximizar o engajamento e o sucesso acadêmico de cada aluno. O feedback específico e imediato desempenha um papel crucial no processo de aprendizagem individualizada, permitindo que os alunos compreendam seus pontos fortes e áreas de melhoria, além de incentivá-los a progredir em suas habilidades e conhecimentos. Isso contribui para a construção de uma base sólida para o crescimento e o desenvolvimento contínuo dos alunos.