bluuebunny/crossref_metadata_2025 huggingface dataset:
Fluorescent Antimicrobial Peptides Based on Nile Red: Effect of Conjugation Site and Chemistry on Wash-free Staining of Bacteria
Authors: Weiss Lucille , Mirloup Antoine , Blondé Léa , Manko Hanna , Peluso Jean , Bonnet Dominique , Dziuba Dmytro , Karpenko Julie
Published: September 2024

Fluorescent probes for bacterial detection can be obtained by conjugating antimicrobial peptides with fluorescent dyes. However, little is known about the effect of the conjugation site and linker chemistry on staining efficiency. We synthesized three conjugates of the antimicrobial peptide ubiquicidin with the environmentally sensitive fluorophore Nile Red that differed by the attachment site and the chemical composition of the linker. We showed that incorporating fluorophore as a minimalistic non-natural amino acid resulted in a superior probe compared with the typically used bioconjugation approaches. The new peptide-based probe named UNR-1 displayed red fluorescence and enabled robust wash-free staining of Gram-positive and Gram-negative bacteria. The probe exhibited selectivity over mammalian cells and enabled rapid fluorescence detection of bacteria by fluorescence microscopy and flow cytometry in an add-and-read format. Our results may foster the development of next-generation fluorescent AMPs for clinical laboratory diagnostics and medical imaging.
Computational Investigation of the Chemical Bond Between An(III) Ions and Soft Donor Ligands
Authors: ROY CHOWDHURY SABYASACHI , Rehberg Naomi , Vlaisavljevich Bess
Published: September 2024

The chemical bonding of actinide metal ions with both arene and borohydride ligands is explored via quantum chemical methods to understand how the transuranic elements differ from uranium with respect to their interaction with soft donor ligands. Specifically, the [An(arene)(BH4)3] complexes (AnMe6 , An = Np, Pu, U, arene C6Me6) are studied. Density functional theory (DFT) shows that, when the complexes are neutral, the interaction between the metal ions and the soft-donor ligands is governed by electrostatic interactions. Molecular orbital analysis, with both the DFT and the complete active space (CASSCF) method, shows that as one moves from U to Pu, the energy gap between the 5f orbitals of the metal ion and the ligand π∗ orbitals gradually increases, leading to a weaker metal-ligand interaction. Upon reduction to AnMe6−, the An–arene distances contract by 0.1-0.2 ̊A compared to the neutral complex, leading stronger metal-ligand interactions with varying degrees of δ-bonding depending on the actinide. Specifically, orbital mixing decreases from UMe6− to PuMe6−. In the high-spin state, UMe6− has two electrons in the two δ-bonding orbitals, while NpMe6− and PuMe6− have only one electron in a single δ-bonding orbital. In the lower-spin states, these bonding orbitals become even more delocalized and the population of the δ∗ orbital increases from U to Pu. This is consistent with the increased An–arene distances, weaker interactions, and decreasing covalency across the series.
Pan American climate resilient health systems: a training course for health professionals
Authors: Sorensen Cecilia , Barboza Carolos , Berry Peter , Buss Daniel , Campbell Haley , Hadley Kristie , Hamacher Nicola , Magalhaes Danielly , Mantilla Gilma , Mendez Anwar , Polson-Edwards Karen , Stewart-Ibarra Anna , Torres Irene
Published: September 2024

Objectives

To describe the development, implementation, and results of a training course designed to equip health professionals from the Pan American Health Organization region with the knowledge and tools needed to adapt health systems to current climate realities

Methods

The Pan American climate resilient health systems course was a 9-week live-virtual course in March–April 2023, which was delivered through Zoom and offered in English, Spanish, and French. All lectures were delivered by local and regional climate and health experts. The curricular foundation of this initiative was the Global Consortium on Climate and Health Education core competencies for health professionals. Participants completed pre- and post-course surveys

Results

A total of 1212 participants attended at least one of the nine sessions and 489 (from 66 countries) attended at least six sessions. Of these, 291 participants completed both the pre- and post-course surveys which were used in the analysis. Longitudinal survey results suggested an improvement in participants’ climate and health communication, an increased frequency of incorporating climate knowledge in professional practice, and improved confidence in engaging in climate initiatives. At the same time, many participants expressed a need for additional training

Conclusions

The results indicate that live-virtual courses have the potential to empower health professionals to contribute to climate resilience efforts by: increasing their communication skills; changing their professional practice; increasing their ability to lead climate and health activities; and preparing them to assess vulnerability and adaptation in health systems, measure and monitor environmental sustainability, and apply a health equity lens.
The future of food safety: possible trends for the years 2022‐2032 and their influence on food safety and nutrition
Authors: Delalay Gary , Wagner Cornelia , Lüthi Thomas
Published: September 2024

Abstract
Over the next decade, demographic, societal, technological, economic, environmental, and political factors are expected to significantly influence the agri‐food chain. Demographic shifts, characterised by an aging population and sustained migration, along with evolving consumer demands, will drive a greater emphasis on sustainability. This includes increased consumption of organic, locally produced, and "clean label" products (containing few ingredients and no additives), as well as a resurgence in home‐made food. Personalised nutrition, vegan and vegetarian diets, and alternative protein sources will gain prominence. Technological advancements will introduce new raw materials, such as novel protein sources and genetically engineered products, while innovative agricultural methods like vertical farming (involving the use of new agricultural surfaces) and digitalised "smart" production chains will optimise food production. Emerging processing techniques, including 3D food printing and non‐thermal plasma processing, alongside sustainable packaging innovations, will reshape food manufacturing. Additionally, advancements in laboratory diagnostics, such as whole genome sequencing and microbiome analysis, will enhance food safety and quality control. Economically, the personalisation of food, driven by microbiome analysis and psychotropic comfort foods, is poised to be lucrative. The food experience will be enriched through new textures and recycling or upcycling of food waste into novel products. New business models, like "ghost kitchens," will also emerge, reflecting shifts in food distribution patterns influenced by the COVID‐19 pandemic. Environmental challenges, particularly those arising from climate change, will alter precipitation patterns in Switzerland, potentially disrupting food imports from affected regions. Politically, Switzerland's food safety regulations will be influenced by international frameworks such as the UN's Agenda 2030 and the EU's Green Deal. While Switzerland can quickly respond to new food safety threats, slow legislative changes may create trade barriers with the EU. These trends underscore the need for dynamic policy adaptation to ensure food safety and sustainability in a rapidly evolving global landscape.
IDENTIFYING THE INTELLECTUAL FRAMEWORK OF GREEN HRM: A BIBLIOMETRIC ANALYSIS
Authors: Verma Ravish Chandra , Singh Rajat Kumar , Kumar Rishi Bhushan
Published: September 2024

This study offers a comprehensive bibliometric analysis of the literature on Green Human Resource Management (GHRM) from 2013 to 2023. The Scopus database is used as the main source for extracting data. The study includes article titles, abstracts, keywords, authors, affiliations, publication dates, and citation counts. It utilizes descriptive statistics, trend analysis, and citation metrics to reveal important findings. The findings demonstrate a significant rise in GHRM research throughout the previous decade, with journal papers being the prevailing mode of publishing. The journal Sustainability, based in Switzerland, has the top position as the most significant publication in the subject. It is closely followed by the International Journal of Manpower and the Journal of Cleaner Production. The report further highlights prominent researchers and collaborative networks, emphasizing the significance of cooperation in advancing GHRM research. Significant developments in leadership, innovation, environmental performance, and employee behaviour are observed as key topics. This study not only documents the development of GHRM but also emphasizes important articles and proposes potential areas for further research.
INSIGHTS INTO EXPANSION: A SWOT ANALYSIS & NEED ASSESSMENT OF TAPIOCA MICRO FOOD PROCESSING INDUSTRIES IN SALEM DISTRICT, TAMIL NADU
Authors: Bharathi Venkatesa Palanichamy Narasimma , Muthuswamy Kalpana , Natarajan Balakrishnan , Vasudevan Balamurugan , Appavu Suresh , Marimuthu Rajavel , Rajaram Dhivya
Published: September 2024

Tapioca is a significant crop in Tamil Nadu, India, with Namakkal, Salem, and Kallakurichi being the top producers, with Salem District contributing 13.36%. Micro processing industries play a pivotal role in the economic advancement of Tamil Nadu, significantly contributing to the generation of employment opportunities, revenue, and general economic growth. While the industry study revealed strengthen like naturally formed clusters, successful marketing efforts, and easy access to financial institutions and new technologies, there are also weaknesses like challenges with raw material availability, declining cultivation rates, and environmental concerns. Opportunities for growth include increasing sago consumption, developing value-added products, effective branding strategies, and exploring potential by-products. Threats include competition from new products and imports, high customer expectations, and the use of maize starch as a substitute. Challenges in the industry include the need for harvesting machinery on agricultural farms and processing equipment in sago industries, as well as limited access to institutional finance. Increasing marketing efforts to expand the market for sago and starch products in India, particularly in Tamil Nadu could be beneficial.
EXPLORING THE POTENTIAL: A COMPREHENSIVE ANALYSIS OF THE TAPIOCA MICRO FOOD PROCESSING INDUSTRY IN SALEM DISTRICT, TAMIL NADU
Authors: Bharathi Venkatesa Palanichamy Narasimma , Muthuswamy Kalpana , Natarajan Balakrishnan , Vasudevan Balamurugan , Appavu Suresh , Marimuthu Rajavel , Rajaram Dhivya
Published: September 2024

Tapioca, a key crop in Tamil Nadu, could support sustainable growth in micro food processing enterprises in the Salem district. The district accounts for 12% of the state's area and produces 13.36% of the state's sago, with high-quality starch production. Micro food processing businesses in the Salem district contribute to the local economy, providing employment and contributing to overall growth. The study revealed district is dominated by processing unit owners over 50 years old, with 20% owned by women and 80% by men. Most processors have 21-30 years of experience and belong to nuclear families. New mechanical methods have increased efficiency in making sago and extracting starch. Sago processing units in Salem face challenges such as equipment shortage, labor scarcity, loan availability, price fluctuations, quality deterioration, and drying issues. Most processing unit owners prefer to market their products through Channel III, which includes Farmer, Processor, Sago-serve, Trader, Wholesaler, and Retailer. The majority sell their products to Sago-serve Cooperative Society Ltd in Salem. Investing in infrastructure and supporting small-scale food processing enterprises is crucial for promoting economic growth and development in the district.
ONLINE RETARGETING ADVERTISEMENTS AND CONSUMER BEHAVIOUR
Authors: Sane Sandip , Anute Nilesh , Tripathi Diksha , Shinde Vanandana Hindurao
Published: September 2024

The effect of online retargeting adverts on customers' buying decisions is examined in this study article. A mixed-methods research approach was used, incorporating the collection of both quantitative and qualitative data. 500 web users who were exposed to retargeting adverts made up the sample. According to the data, there is a link between seeing retargeting advertising and making decisions to buy, suggesting that the likelihood of buying increases with exposure to these ads. The significance of individualised and non-intrusive ad experiences is highlighted by the enormous influence that attitudes and perceptions towards retargeting advertising have on purchasing decisions. The report emphasises the necessity for marketers to take into account the sustainability and long-term implications of retargeting techniques, including elements like ad fatigue and privacy issues. The limitations of the study include a focus on a specific demographic and the use of self-reported measures. Future research could explore individual differences, the specific content and design aspects of retargeting ads, and comparative effectiveness across different advertising channels. The findings contribute to the understanding of the complex relationship between retargeting advertisements and consumer behavior, providing insights for marketers to optimize their advertising strategies and enhance purchase decisions.
Parecer técnico sobre a incorporação do uso de Rituximabe em monoterapia no SUS para pacientes com linfoma folicular assintomático
Authors: Mello Ramon Andrade B de
Published: September 2024

O presente parecer técnico tem como objetivo analisar a incorporação do uso de Rituximabe em monoterapia no SUS para pacientes com linfoma folicular assintomático. Trata-se de uma doença que afeta o sistema linfático e, mesmo em estágios iniciais, pode trazer complicações a longo prazo. A utilização do Rituximabe tem se mostrado eficaz no tratamento dessa condição, proporcionando melhores resultados clínicos. Além disso, é importante ressaltar que a utilização desse medicamento em monoterapia traz benefícios econômicos ao sistema de saúde, pois reduz a necessidade de outros tratamentos mais invasivos e custosos. Dessa forma, a incorporação do Rituximabe em monoterapia no SUS para pacientes com linfoma folicular assintomático se mostra uma medida necessária e benéfica para a melhoria da qualidade de vida desses pacientes.
Tongue Squamous CELL carcinoma in young pacients whithout known risk factors: Case Report
Authors: Araujo Camila G. , Almeida Melyna Marques de
Published: September 2024

Uma maior ocorrência do carcinoma espinocelular de boca em pacientes jovens e sem fatores de risco vem sendo observada, sendo a língua o local de maior frequência nessa população. O objetivo deste trabalho é relatar o caso clínico de um paciente jovem, sem vícios, diagnosticado com carcinoma espinocelular de língua. Relato de caso: Paciente de 45 anos, sexo masculino, motorista, procurou a clínica odontológica com a queixa principal de um caroço na língua. Durante a anamnese, não relatou vícios, como tabagismo ou etilismo. Ao exame físico intra-bucal, observou-se a presença de um nódulo localizado em borda lateral e posterior da língua, indolor e sem relação de trauma, com tempo de evolução de aproximadamente 1 mês. Diante dos aspectos clínicos observados, procedeu-se à biópsia incisional e o diagnóstico final foi de carcinoma espinocelular de língua. Embora incomum, o presente caso clínico evidencia um diferente perfil da doença, acometendo pacientes jovens, sem vícios e cujo prognóstico ainda é incerto. Sugere-se uma influência genética na etiopatogenia da doença, porém, ressalta-se a importância da investigação de novos fatores etiológicos associados, visto o aumento de casos em pacientes sem vícios. Este caso clínico reforça a importância do diagnóstico precoce das lesões bucais, especialmente o CEC. Além disso, há a necessidade de uma profunda investigação sobre novos hábitos em pacientes jovens diagnosticados com carcinoma espinocelular, uma vez que os fatores etiológicos desse grupo ainda são incertos.
Palavras-chave: Neoplasias da língua. Carcinoma de células escamosas. Adultos.
Denise Tostes Oliveira3
Melyna Marques de Almeida4
Agnes Assao1,5
RELATO DE CASO I
CASE REPORT
Melyna Marques de Almeida
Os autores
FARMACOGENÉTICA DOS INIBIDORES DA ENZIMA CONVERSORA DE ANGIOTENSINA (IECA)
Authors: GOMES ROOSEVELT ALBUQUERQUE , LAGO CLEBER MENDES PEREIRA DO , NÓBREGA HAYANNE OLIVEIRA DA SILVA , GUIMARÃES GEOVANI PEREIRA , SOUTO GUSTAVO PEREIRA DE , BARBOZA ISABELA DE ARAÚJO , FREIRE MARIA LARISSA PEREIRA DA COSTA , SOARES RENATA ALCANTARA , FERREIRA SABRINA DE ARRUDA COSTA , RODRIGUES THIAGO PEIXOTO
Published: September 2024

Introdução: A hipertensão arterial sistêmica (HAS) é uma das principal causa de doenças cardiovasculares globais.
Diversas classes de medicamentos anti-hipertensivos são consideradas terapias de primeira linha. No entanto, a resposta
aos Inibidores da Enzima Conversora de Angiotensina (IECA) varia entre os pacientes, e a variação genética pode ser um
marcador útil para prever a eficácia desses medicamentos. Objetivo: Analisar a literatura científica disponível e compilar
os dados sobre a influência dos polimorfismos genéticos na resposta aos Inibidores da Enzima de Conversão da
Angiotensina (IECA), com foco em identificar variantes genéticas associadas à eficácia e segurança desses medicamentos
no tratamento de condições cardiovasculares, em especial, a hipertensão arterial. Metodologia: Trata-se de uma revisão
integrativa da literatura. O referido estudo envolveu pesquisa nas bases BVS-BIREME e PubMed, selecionando estudos de
metanálise e ensaios clínicos randomizados dos últimos cinco anos, utilizando os descritores "pharmacogenetic", "ACE
inhibitors" e "hypertension". Os artigos selecionados investigaram a relação entre polimorfismos genéticos e a resposta
clínica aos IECA, publicados em inglês ou português. Resultados e Discussão: A busca nas bases de dados resultou em 9
estudos, dos quais 4 foram selecionados após aplicação dos critérios de inclusão e exclusão. Os estudos abordaram a relação
entre polimorfismos genéticos e a resposta clínica aos IECA. Os resultados sugerem que polimorfismos no gene ACE (I/D)
estão fortemente associados à variabilidade na resposta aos IECA, com pacientes portadores do alelo D apresentando uma
resposta menos eficaz comparados aos portadores do alelo I. Estudos mostram que indivíduos com genótipo II
(inserção/inserção) têm melhores resultados terapêuticos com doses menores de IECA. Considerações Finais: A
farmacogenética dos IECA é promissora para personalizar o tratamento cardiovascular. Polimorfismos genéticos como
ACE (I/D), AGT (M235T) e AGTR1 (A1166C) são fundamentais na variabilidade da resposta aos IECA.
FATORES DE RISCO PARA MALFORMAÇÕES CARDÍACAS FETAIS: UMA AVALIAÇÃO DETALHADA
Authors: HASEGAWA IASMIN , WOOD LUCIANA CRISTINA PEREIRA , MORAIS FABIANA DE , SENA KETTILLY GEISANE SILVA DE , JOTER KELCIONE PINHEIRO LIMA , ARAÚJO ANDRESA PINTO DE , SILVA JAQUELINE ALESSANDRA CASTRO DA , BRITO KARLA DANIELLA ALMEIDA OLIVEIRA DE , INÁCIO JORDANNA PORTO , SANTOS THIAGO LÚCIO DOS
Published: September 2024

Introdução: As malformações cardíacas fetais representam um desafio significativo na medicina fetal, impactando tanto a
saúde materna quanto a neonatal. Objetivo: Realizar uma avaliação detalhada dos principais fatores de risco associados às
malformações cardíacas fetais. Metodologia: Compete a uma ampla revisão integrativa da literatura, conduzida em 2024
mediante consulta às bases de dados LILACS, MEDLINE, IBECS e WPRIM. Resultados e Discussão: Os fatores de risco
para malformações cardíacas fetais incluem sexo masculino, nascimentos múltiplos, idade materna avançada (igual ou
superior a 35 anos), idade paterna abaixo de 20 anos, registro domiciliar materno não local e residência em áreas rurais.
Outros fatores associados são a ocorrência de câncer materno durante a gravidez, condições específicas como cardiopatias
congênitas complexas, e o uso de certos medicamentos durante a gestação. Considerações Finais: Conclui-se que a
identificação precoce e a gestão dos fatores de risco são cruciais para mitigar o impacto das malformações cardíacas fetais.
Futuras pesquisas devem enfatizar estratégias preventivas e de intervenção precoce para melhorar os resultados neonatais
e maternos.
INTELIGÊNCIA ARTIFICIAL NA ASSISTÊNCIA A SAÚDE HOSPITALAR: BENEFÍCIOS, DESAFIOS E PERSPECTIVAS PARA O FUTURO
Authors: NASCIMENTO FRANCIRÔMULO DA COSTA , SOUZA WESLEN BENTO DE , MATOS JESSICA MARIA PEREIRA , SILVA ANA FLÁVIA CARVALHO , BARROS TAMIRES ROCHA , SEGURA TAMIRES FURTADO , MARCHESINI GUILHERME NASCIMENTO , TINOCO JULIANA , TOMAZ ALESSANDRA APARECIDA BIANCHESI , PERLIRA JOÃO MARCUS VASCONCELOS
Published: September 2024

Introdução: A introdução da Inteligência Artificial (IA) na saúde hospitalar transforma a medicina, elevando a precisão
diagnóstica e a eficiência operacional. No entanto, enfrenta desafios como privacidade de dados e a exigência de
infraestruturas. Objetivo: Analisar como a inteligência artificial afeta a assistência médica hospitalar, focando em
benefícios como eficácia clínica e eficiência operacional, desafios éticos e técnicos, e possíveis futuros desenvolvimentos.
Metodologia: O estudo é uma revisão narrativa conduzida em julho de 2023 focada na influência da Inteligência Artificial
(IA) na assistência médica hospitalar. A pergunta central da pesquisa é "Como a inteligência artificial influencia a
assistência médica hospitalar em termos de benefícios, desafios e perspectivas futuras?". O método de pesquisa adotado
segue a estratégia PICo, que examina Pacientes com assistência médica apoiada por IA, a Intervenção de tecnologias de IA
em hospitais, a Comparação com a assistência médica sem IA, e o Resultado/Outcome em eficiência, precisão e
personalização do atendimento. Uma busca sistemática da literatura foi realizada em várias bases de dados acadêmicas,
como PubMed, Scopus, Web of Science, CINAHL, LILACS e Embase. Os descritores em saúde incluíram termos como
"Inteligência Artificial", "Unidades Hospitalares", e “Sistemas de Apoio a Decisões Clínicas”, combinadas de maneira
apropriada com os operadores booleanos AND e OR, nos idiomas em inglês, português e espanhol. Resultados e
Discussão: Nos estudos analisados nesta revisão, demostram o impacto da Inteligência Artificial (IA) na assistência médica
hospitalar. A IA contribui para diagnósticos mais precisos e tratamentos personalizados, aumentando a eficiência. No
entanto, desafios como ética, segurança de dados e aceitação ainda precisam ser superados para uma implementação segura
e eficaz no futuro. Considerações Finais: A Inteligência Artificial (IA) na assistência médica aumenta a eficiência e
precisão, mas enfrenta desafios éticos, de privacidade e aceitação. É essencial equilibrar essas questões éticas, legais e
regulatórias para promover a saúde.
AMOR AO DIREITO
Authors: BORGES ELIANE CATARINA FLORENCE
Published: September 2024

Poucas coisas na sociedade têm o poder de mudar ambientes e pessoas. O operador do Direito, sem paixão, não conclui a graduação. Ler as obras de Rui Barbosa nos leva ao passado, que, em algumas vezes, ainda está tão presente. Até hoje, não li em nenhuma de suas obras algo que desmotive se a respeito do Direito. Como não ter paixão por algo que transforma a sociedade?
Additional Gold Recovery from Tailing Waste By Ion Exchange Resins
Authors: Ashrapov UT , Malikov Sh R , Erdanov MN , Mirzaev BB
Published: September 2024

The article describes the gamma activation analysis method used to determine the gold content in rock samples using the Aura measuring complex. The physicochemical basis of gold extraction in the process of cyanide leaching is considered. The technology for extracting gold from solutions of tailing waste “ponds” of tailings dumps of hydrometallurgical plants of the Joint Stock Company “Navoi Mining and Metallurgical Combine” (JSC NMMC) is presented. It has been shown that in the dynamic mode of sorption of tailing waste solutions acidified to pH = 3.3÷3.5 through AM-2B and VP-1P ion exchange resins, gold is sorbed on the AM-2B anion exchanger up to 3.9 mg/g and on the VP-1P anion exchanger up to 1.5 mg/g. It has been shown that when solutions of tailing waste are exposed to ammonia, ammonia complex compounds of base metal impurities are formed, which decompose, while the gold cyanide complex does not decompose and is sorbed on the AM-2B ion exchange resin up to 3.0 mg/g. The mechanisms of the chemical reactions of the process of extracting gold from tailing waste and the technological scheme of the installation for extracting gold from solutions of the tailing waste “pond” are presented.
Widening the Archival Sliver: Availing and Available Archival Materials Tied to Apartheid-Era African-Staffed Military Forces
Authors: Raber Richard Levi
Published: September 2024

Abstract: African-staffed apartheid-era military forces now command scholarly attention. I outline relevant archival holdings that survived the mass destruction of documentation as apartheid crumbled, suggesting that additional publicly available materials exist in underutilized archives. Composed of both official and vernacular materials, these sources are less likely to support research into studies of military tactics or strategy, but they offer glimpses into the day-to-day mechanics of these forces and more vividly, the militarized cultural worlds underpinning them. They offer insights into labor, cultural, and social histories. This has relevance for southern African history, and more broadly, for scholars interested in colonial military rule, democratization, the Cold War, and colonialism and its aftermath in Africa. I conclude by calling on scholars to work with military veterans and their families to facilitate archival donations.
TIME OF HOST-SEEKING OF MOSQUITO VECTOR SPECIES ON THE TEMPE CAMPUS OF ARIZONA STATE UNIVERSITY
Authors: KALMOUNI JOSHUA , WILL JAMES B. , TOWNSEND JOHN , PAAIJMANS KRIJN P.
Published: September 2024

The Arizona State University (ASU) Tempe campus is inhabited by some 55,000 enrolled students as well as several mosquito species that can transmit West Nile virus, dengue, Zika, chikungunya, and yellow fever. The time of host-seeking of these vectors has not been quantified on the ASU Tempe campus, but this information is important to inform ground and/or truck-mount fogging operations targeting mosquitoes to prevent or control disease outbreaks. We quantified the time of host-seeking of the predominant mosquito vector species at the ASU Tempe campus during the post-monsoon season in 2021, using collection bottle rotators with encephalitis vector survey traps that were baited with CO2, at 3 h intervals during a full day. Culex quinquefasciatus, Aedes aegypti, and Culex tarsalis were the most abundant species captured. Pre-midnight host-seeking (18:00–00:00) accounted for 52% of all captures, whereas post-midnight host-seeking (00:00–06:00) accounted for 35% of all captures. Peak activity times were between 21:00 and 00:00 for Cx. quinquefasciatus and Cx. tarsalis, and between 15:00 and 18:00 for Ae. aegypti. Data can be used to inform local mosquito surveillance and control programs.
Impact of personalization on customer loyalty: A study on online retail businesses of Bangladesh
Authors: Kanij Fatema Tumpa
Published: September 2024

Nowadays, online retailers are taking various tactics in terms of marketing and providing greater customer services where personalization is one of them where the retailers intend to fulfill customers' needs according to their preferences. This study proposes to find out the impact of personalization on customer loyalty in online retail businesses in Bangladesh. And, to conduct the research, primary data has been collected through a questionnaire survey which is distributed to 150 customers who have purchased from online retailers. After that, the collected data were analyzed through MS Excel using multiple regression analysis, correlation analysis, and descriptive statistics. According to the results, there is a significant and positive relationship between 3 personalization factors including one-to-one personalization, co-creation, and personalized webpages with customer loyalty. Hence, a higher level of personalized services can ensure a higher level of customer loyalty.
New approaches for management of diabetes mellitus: A review
Authors: N. RAJAVEL  , RAHIMA  , KR. PRIYADHARSHINI  , M. FATHIMA BASHEERA
Published: September 2024

Diabetes mellitus is a multifaceted, non-communicable endocrine condition marked by persistent hyperglycaemia and related complications that impact multiple organs. The incidence of DM is on the rise, with estimates predicting over 640 million cases worldwide by 2040. This review explores innovative strategies for diabetes management, highlighting advancements in nanotechnology, statin therapies, stem cell treatments, gene therapy, and herbal remedies. Each strategy offers distinct advantages and challenges, ranging from nanotechnology's capability for continuous glucose monitoring and targeted drug delivery to the role of statins in mitigating cardiovascular risks among diabetic patients. Furthermore, stem cell methods and gene therapy present promising prospects for creating insulin-producing cells and providing immunological interventions, while herbal treatments serve as effective adjuncts with minimal side effects. Despite these advancements, a definitive cure for DM remains elusive, emphasizing the necessity for comprehensive management strategies. The review underscores the significance of achieving optimal metabolic control and advocating for public health initiatives that enhance healthcare accessibility and foster patient-centered care. Ultimately, a holistic approach that integrates these emerging technologies and therapies could lead to improved therapy of diabetes and its related complications.
Treatment of white spot lesions: A minimal intervention approach: Case Repor
Authors: Kassandra Elizabeth Sigüenza González  , María Isabel Cordero Coronel  , Daniela Astudillo-Rubio
Published: September 2024

Background: A case report that seeks a minimally invasive alternative as a solution to one of the problems in dental esthetics, the presence of white spots. Objective: To identify non-invasive alternatives for the elimination of white spots in healthy teeth. Methods: Two patients were selected with white stain lesions on the vestibular surface. Three different techniques were applied for the removal of white stains. One technique called Microabrasion (Opalustre, Ultradent), another technique known as Infiltration (Icon Vestibular, DMG) and finally a combination in which both products were applied, following in all cases the manufacturer's indications. Results: The different techniques and products eliminated the white spot lesion when these are no more than 0.20 mm deep at the enamel level. Conclusions: Enamel alterations which can be related to different factors such as white spots caused by caries in the first phase, hypomineralization, hypoplasias in dental pieces of which an alternative treatment is the use of microabrasion (Opalustre, Ultradent), and infiltrating resins (Icon Vestibular, DMG) as a non-traumatic method for the dental pieces, thus maintaining their structure without tenacity.
Betel nut chewing effects on the incidence of periodontitis
Authors: Reza Agustina  , Amirah Mujahidah  , Titiek Berniyanti
Published: September 2024

Background: Betel quid chewing, a common cultural practice in various parts of Asia, has been associated with numerous oral health issues, including periodontitis. Betel quid chewing, which involves the consumption of a mixture of areca nut, lime, betel leaf, and sometimes tobacco, is a common practice in several Asian countries, including Indonesia. Several studies have indicated a connection between this habit and various oral health problems, including periodontitis, a chronic inflammatory condition affecting the supporting tissues of the teeth. This systematic literature review aims to explore the relationship between betel quid chewing and the incidence of periodontitis. Method: The method used is a systematic review which is done by searching articles through Google Scholar, PubMed, and ScienceDirect. Discussion: The review's findings indicate that betel quid chewing significantly increases the risk of periodontitis. The pathophysiological mechanisms involve chronic irritation and alterations in oral microflora induced by the components of betel quid, ultimately leading to inflammation of periodontal tissues. Some studies also suggest that the duration and frequency of betel quid chewing are positively associated with the severity of periodontitis. Conclusion: There is strong evidence supporting the hypothesis that betel quid chewing is an important risk factor for the development of periodontitis.
Living Qur’an di Rumah Sakit Islam Purwokerto
Authors: Nurasih Wiji , Amalia Futihat Rizqi , Sa’idi Ahamd Muthohar
Published: September 2024

Today more and more Islamic religious foundations are popping up not only in the realm of Islamic educational institutions or da'wah institutions but have penetrated other fields including healthcare institutions such as hospitals. In Purwokerto itself there are several hospitals established by Islamic foundations, one of which is the Purwokerto Islamic Hospital (RSI). This is of particular interest to find out the uniqueness of hospitals established by Islamic religious foundations, including the service aspect in relation to the spiritual values applied therein. RSI Purwokerto itself uses one of the verses of the Koran as the philosophy that underlies the hospital and all its service processes, namely the letter Asy-Syu'ara verse 80 which means if I am sick, only He can heal me. Therefore, in this study, researchers are trying to explore how to implement this verse in the process of health services at RSI Purwokerto. This qualitative research was carried out by directly observing RSI Purwokerto, conducting interviews, and reviewing documentation of RSI Purwokerto. The study focused on the Islamic Spiritual Guidance Division which holds religious authority and responsibility at RSI Purwokerto. From this study, it was found that the letter asy-Syu'ara verse 80 is applied in the health services of the Purwokerto Islamic Hospital in various ways, including providing Islamic motivation to patients, inviting patients always to expect healing to be given by Allah SWT, broadcasting Islamic studies for patients and employees and so on.
Analisis Hukum Ikhtilath dalam Al-Qur’an
Authors: Nabila Putri Najah
Published: September 2024

Interaksi antara laki-laki dan perempuan yang dalam konteks Islam dikenal dengan istilah ikhtilath, telah menjadi topik yang kompleks dan relevan dalam kajian hukum Islam, yang mana di zaman sekarang ini banyak terjadi penyimpangan dan pelanggaran batasan berinteraksi antar gender. Ikhtilath dapat menjadi pintu menuju perbuatan zina, yang tercermin dari berbagai fenomena yang semakin marak belakangan ini, seperti meningkatnya kasus perzinahan, perceraian, perselingkuhan, bahkan tindakan pembunuhan yang dilatarbelakangi oleh hubungan terlarang antara laki-laki dan perempuan. Oleh karena itu, penelitian ini bertujuan untuk membahas bagaimana hukum ikhtilath dalam Islam menurut perspektif Al-Qur’an dan aturan-aturan dalam Islam terkait dengan interaksi antar gender. Penelitian ini menggunakan metode kualitatif, yang melalui pendekatan kepustakaan dengan mempelajari berbagai referensi dari hasil penelitian sebelumnya yang berkaitan dengan permasalahan yang diteliti. Hasil penelitian ini menunjukkan bahwa hukum dasar ikhtilath menurut perspektif Al-Quran adalah haram, bahkan merupakan sesuatu yang sangat dilarang oleh Allah Swt. dengan tegas agar dihindari dan dijauhi oleh umat Islam, karena sesungguhnya ikhtilath merupakan faktor penyebab terjadinya perbuatan zina yang diharamkan dalam Islam, sebagaimana yang terdapat dalam QS. Al-Isra’: 32. Namun, seiring berjalannya waktu, interaksi antara laki-laki dan perempuan menjadi suatu hal yang tidak dapat dihindari karena adanya kondisi-kondisi tertentu dan mendesak. Maka, Islam pun membolehkan pergaulan antara laki-laki dan perempuan dengan syarat menjaga adab dalam berinteraksi, sebagaimana yang dijelaskan dalam surah An-Nur: 30-31, yaitu dengan cara menahan pandangan, menutup aurat, menghindari khalwat, menjaga diri agar terhindar dari perbuatan zina, ditemani oleh mahramnya, serta terhindar dari adanya fitnah yang dapat terjadi apabila ikhtilath tidak dilakukan sesuai dengan syariat Islam.
Design for Longevity:  People, Process, and Platform
Authors: Lee Sheng-Hung , Sicklinger Andreas
Published: September 2024

This experimental research study explores the concept of longevity in the context of design. It emphasises the importance of creating meaningful and impactful solutions to complex social-technological challenges posed by an ageing population and the longevity economy. In the context of the diid issue, different authors discuss the role and influence of design and the creative process in addressing issues related to longevity, and celebrating people’s independence, health, finance, and quality of life through innovative products, processes, places, and platforms. It introduces the concept of Design for Longevity (D4L), which incorporates comprehensive considerations encompassing family dynamics, housing, community engagement, health, education, investment, risk, and advocating for the individual’s multiple life stages with purpose and respect. The introductory paper also highlights the contribution of D4L in the ongoing discourse on the social impact of design in fostering community building, social interaction, and engagement among older adults to enhance longevity, literacy, fitness, and well-being.
New Technologies, Old Professors: Notes on Labor Ageing in Design Programs
Authors: Catalina Olivas Castellanos Elsa , Salas Díaz Fabiola , De Gunther Delgado Leonel
Published: September 2024

This paper discusses why higher education professors are not retiring in due time and how economic programmes play a role in such a decision. We discuss public policies of higher education institutions to understand 1) why labour ageing occurs and 2) the challenges faced by professors and institutions. Our discussion focuses on showing how a series of policies and organisation-led rules can condition practices, thus contributing to labour ageing, by discussing the case of a country: Mexico. Due to public and university policies, labour ageing presents a challenge for university education. In that case, these policies must be accompanied by training processes for the lifelong productivity of professors. This paper shows the need to reevaluate practices to constantly address labour ageing in design academia, so that it might evolve and remain up-to-date with emerging trends and technologies.
Co-create and Co-develop With Children. The BODYSOUND Engagement Model
Authors: Sedini Carla , Cipriani Laura , Maffei Stefano , Bianchini Massimo
Published: September 2024

The article explores the use of participatory design processes, methods, and tools to develop interactive healthcare and wellbeing solutions involving children with motor disabilities and their caregiving system. This contribution provides a theoretical framework focused on the engagement roles that children participating in co-design processes can play, providing the description of BODYSOUND, a pilot project developed within the SISCODE H2020 European project. We will present the co-design process divided into two main phases: co-creation and co-development. For each of these phases, we carried out iterative design actions that will be presented according to the role with which children are engaged, the targets involved, and methods to collect data. All of these were subjected to the primary goal of each design action. The final part systematizes the results of the analysis and identifies different goals and methods for children’s participation according to specific design phases.
The Practice of Anticipation as a Skill for Designing Possible and Preferable Futures
Authors: Cristina Borba da Cunha Ana , Franzato Carlo , Pellanda Eduardo , Yaneth Ramirez Triana Nelida , Schneider Amaral Simone , Vai Elena , Cristina Visoná Paula
Published: September 2024

The paper discusses Damasio’s homeostasis theory and its potential connection to design. It starts with the evolution of physiological regulation from the Hippocratic theory of body humours through Claude Bernard’s milieu intérieur, Walter Cannon’s formulation of the concept of homeostasis, culminating with Damasio’s homeostasis theory emphasising conscious homeostatic feelings, besides the unconscious mechanisms of physiological control. Next, it shows the importance of Damasio’s homeostasis theory in perception, consciousness, as well as affect and wellbeing, and how it can inform the design discourse, specifically regarding emotions, embodiment, and environment. It poses questions such as whether design could be viewed as an extension of ourselves, acting as a psychic stabiliser or destabiliser. It argues that how we feel may eventually serve as a homeostatic design guide and that knowledge of homeostasis may improve wellbeing and the built environment.
HUKUM KELUARGA ISLAM DALAM PERUNDANG-UNDANGAN REPUBLIK INDONESIA TAHUN 1945-PASCA REFORMASI
Authors: Sudianto Sudianto
Published: September 2024

Posisi hukum Islam dalam dinamika politik di Indonesia, sejak berdirinya di tahun 1945 hingga pasca reformasi tahun dua ribu dua puluhan perlu dicermati untuk memahami landasan-landasan politik dan landasan sosial terhadap kelangsungan atau perubahan hukum Islam di Indonesia dalam rangka politik hukum dalam pemerintahan Negara Republik Indonesia serta respon masyarakat terhadapnya. Penelitian ini meniktik beratkan hubungan antara hukum Islam dan politik dalam negara Republik Indonesia dalam berbagai regim yang berkuasa. Pembahasan ini menggunakan pendekatan sosio-historis yang bertujuan untuk menemukan titik awal masalah yang jadi obyek penelitian. Konsentrasi tulisan ini adalah perkembangan masalah utama yang ditelaah hingga ditemukan titik asalnya. Perhatian utamanya adalah keseluruhan sejarah perubahan dan kelangsungan yang terjadi guna menemukan bentuk atau sistem dasar yang merupakan latar belakang masalah dalam telaahan. Pendekatan yang dilakukan adalah dengan melihat bagaimana suatu obyek terjadi  disebabkan oleh obyek-obyek yang lain yang kemudian diteliti faktor-faktor apa yang menyebabkan obyek tersebut terjadi, kondisi lingkungan, konteks sosial, dan kultural, sampai menemukan titik original secara menyeluruh dan secara sosiologis ditelaah situasi sosial yang  mengitarinya. Pendekatan secara sosio–historis  digunakan dengan  mempertimbangkan bahwa analisa sejarah dan aspek sosiologis akan dapat melihat secara obyektif, tajam, dan jernih tentang posisi hukum Islam dalam perpolitikan di Negara Republik Indonesia.
Asma Binti Abu Bakar and the Hadith on Inter- Religious Relations: Perspectives in Contemporary Societies
Authors: Binte Sellamat Nenny Suzanah , Ariffin Tajul , Kosasih Engkos
Published: September 2024

Introduction: Inter-religious relations is a key factor to ensure peace and harmony, nationally and globally. Throughout history, there were many examples of religious turmoil or civil unrest due to absence or failure or lack of constitutional action or laws that govern diverse societies towards peaceful and harmonious co-existence, or inefficient strategies to manage the sociological impacts of law. Positive inter-religious relations were already modeled by Muhammad (PBUH), through the Medina Charter or through his conduct and approach in volatile and hostile Mecca, just after his migration to Medina. One lesser-known but important contributors of hadith is Asma Binti Abu Bakar, who narrated a hadith on inter-religious relations that is relevant across time. In contemporary times, the state of inter-religious relations is dependent on various factors such as a country’s constitution, laws and social strategies, and the efforts of the government and its religious leaders. The purpose of this study is to analyse the hadith on inter-religious relations. Comparatively, it analysed the model of inter-religious relations in contemporary societies from the global standpoint and within Muslim-majority Indonesia and Muslim-minority Singapore, with a focus on laws and its social impacts. This library-based study is based on a qualitative approach. Primary data was obtained from hadith references, while secondary data was obtained from current research and reports pertaining to the inter-religious relations. The normative approach is engaged in analysing prevalent laws. A descriptive-comparative-deductive approach was used in discussion of the results. The early hadith on inter-religious relations demonstrated the Prophet’s (PBUH) stance and the Islamic approach towards inter-religious relations. There are valuable lessons from this hadith that applies to the Muslim leadership and community. In the context of contemporary and religiously and ethnically diverse societies, the constitution and national laws need to be clear, and all-encompassing, without specific reference to particular groups. Authorities and the Islamic religious leadership need to play active roles in promoting positive inter-religious relations. Corresponding social strategies need to be contextualised to the setting in order to manage differences and complexities.
Синтез и оценка антидепрессивной активности 5-аминозамещенных 3-бром-4-нитро-1-(тиетан-3-ил)-1H-пиразолов
Authors: Клен Елена Эдмундовна , Никитина Ирина Леонидовна , Халиуллин Феркат Адельзянович , Шепилова Светлана Олеговна , Никитина Екатерина Андреевна , Гайсина Гульнара Галиевна , Самородов Александр Владимирович , Павлов Валентин Николаевич
Published: September 2024

5-Аминозамещенные 3-бром-1-(тиетан-3-ил)-4-нитро-1H-пиразолы синтезированы реакциями 3,5-дибром-1-(тиетан-3-ил)-4-нитро-1H-пиразола с алифатическими, ароматическими и гетероциклическими аминами. Структура синтезированных соединений подтверждена с помощью ИК-, 1H и 13С ЯМР-спектроскопии и ГХ/МС. По расчетам in silico для них прогнозируются отсутствие токсических рисков (мутагенности, онкогенности, репродуктивной токсичности, местно-раздражающего действия), низкая токсичность (IV–V класс) и приемлемая пероральная биодоступность. Соединения проявляли разной степени выраженности антидепрессивную активность при однократном внутрибрюшинном введении мышам-самцам. Наибольший эффект характерен для 5-пиперазинопиразолов IIh и IIg, при этом соединение IIh проявляет психоседативные свойства, а соединение IIg — психоактивирующее действие.
Centro de Integración Tecnológica y Digital en Entornos Rurales: Resultados de la convocatoria a Proyectos Federales de Innovación 2022
Authors: Irrazabal E. , Romera L. , Lezcano A. , Carruthers J. A.
Published: September 2024

El trabajo describe un proyecto desarrollado por la FaCENA y la Municipalidad de Yatay Ti Calle en la provincia de Corrientes, Argentina. El proyecto tuvo como objetivo crear un Punto Digital Rural para mejorar la alfabetización digital en comunidades rurales con escaso acceso a plataformas digitales. El proyecto se estructuró en tres fases: el diseño de un manual de calidad y operativo, la  construcción de una aplicación web y la puesta en marcha del Punto Digital Rural en Yatay Ti Calle como prueba piloto. Se adoptaron  prácticas basadas en la normativa ISO 9001 para asegurar la calidad del servicio y como mecanismo de replicación y mejora de otros  posibles Puntos Digitales Rurales en el resto de la provincia. El manual operativo incluyó procedimientos generales y específicos para  garantizar un sistema de gestión de calidad eficaz tal y como lo indica la normativa. El proyecto también planificó un plan anual de  calidad y realizó auditorías internas y externas para la mejora continua. El principal resultado fue la creación de un sistema  documental y tecnológico replicable para otras localidades rurales, mejorando la comunicación y transparencia entre ciudadanos y  administración pública.