bluuebunny/crossref_metadata_2025 huggingface dataset:
Enhanced Immunological Tolerance by HLA-G1 from Neural Progenitor Cells (NPCs) Derived from Human Embryonic Stem Cells (hESCs)
Authors: Zhao Hong-Xi , Jiang Feng , Zhu Ya-Jing , Wang Li , Li Ke , Li Yang , Wang Xiao-Hong , Li Ling-Song , Yao Yuan-Qing
Published: November 2017

Background: Despite the great potential of utilizing human embryonic stem cells (hESCs)-derived cells as cell source for transplantation, these cells were often rejected during engraftment by the immune system due to adaptive immune response. Methods: We first evaluated HLA-G expression level in both hESCs and differentiated progenitor cells. After that, we generated modified hESC lines that over-express HLA-G1 using lentiviral infection with the construct contains both HLA-G1 and GFP tag. The lentivirus was first produced by co-transfecting HLA-G1 expressing lentiviral vector together with packaging vectors into packaging cell line 293T. Then the produced virus was used for the infection of selected hESC lines. We characterized the generated cell lines phenotype, including pluripotency and self-renewal abilities, as well as immune tolerance ability by mixed lymphocyte reaction (MLR) and cytotoxicity assays. Results: Although the hESCs do not express high levels of HLA-G1, over-expression of HLA-G1 in hESCs still retains their stem cell characteristics as determined by retaining the expression levels of OCT4 and SOX2, two critical transcriptional factors for stem cell function. Furthermore, the HLA-G1 overexpressing hESCs retain the self-renewal and pluripotency characteristics of stem cells, which can differentiate into different types of cells, including pigment cells, smooth muscle cells, epithelia-like cells, and NPCs. After differentiation, the differentiated cells including NPCs retain the high levels of HLA-G1 protein. In comparison with conventional NPCs, these HLA-G1 positive NPCs have enhanced immune tolerance ability. Conclusions: Ectopic expression of HLA-G1, a non-classical major histocompatibility complex class I (MHC I) antigen that was originally discovered involving in engraftment tolerance during pregnancy, can enhance the immunological tolerance in differentiated neural progenitor cells (NPCs). Our study shows that stably overexpressing HLA-G1 in hESCs might be a feasible strategy for enhancing the engraftment of NPCs during transplantation.
Breastfeeding indicators trends in Brazil for three decades
Authors: Boccolini Cristiano Siqueira , Boccolini Patricia de Moraes Mello , Monteiro Fernanda Ramos , Venâncio Sonia Isoyama , Giugliani Elsa Regina Justo
Published: November 2017

OBJECTIVE: Update breastfeeding indicators trend in Brazil for the last three decades, incorporating more up-to-date information from the National Health Survey. METHODS: We used secondary data from national surveys with information on breastfeeding (1986, 1996, 2006, and 2013) to construct the time series of prevalence for the following indicators: exclusive breastfeeding in children under six months of age (EBF6m), breastfeeding in toddlers under 2 years of age (BF), continued breastfeeding at one year of age (BF1year), and continued breastfeeding at two years of age (BF2years). RESULTS: The prevalence of EBF6m, BF, and BF1year increased until 2006 (rising from 4.7%, 37.4%, and 25.5% in 1986 to 37.1%, 56.3%, and 47.2% in 2006, respectively). For these three indicators, there was relative stabilization between 2006 and 2013 (36.6%, 52.1%, and 45.4%, respectively). The BF2years indicator had a distinct behavior – relatively stable prevalence, around 25% between 1986 and 2006, and a subsequent increase, reaching 31.8% in 2013. CONCLUSIONS: The time series of breastfeeding indicators in Brazil shows an upward trend until 2006, stabilizing from that date onwards on three of the four indicators evaluated. This result, which can be considered as a warning sign, requires evaluation and revision of policies and programs to promote, protect and support breastfeeding, strengthening existing ones and proposing new strategies so that the prevalence of breastfeeding indicators returns to an upwards trend.
Maternal complications and cesarean section without indication: systematic review and meta-analysis
Authors: Mascarello Keila Cristina , Horta Bernardo Lessa , Silveira Mariângela Freitas
Published: November 2017

OBJECTIVE: The objective of this study was to determine the risks of severe acute maternal complications associated with cesarean section without medical indication. METHODS: A systematic review was carried out with meta-analysis. The literature search was performed systematically, in multiple stages, in the PubMed, Lilacs, and Web of Science databases using the following descriptors: (postpartum period) and (cesarean section or natural childbirth) and ((morbidity or mortality) or (postpartum hemorrhage) or (puerperal infection) or (surgical infection) or (puerperal disorders)). The protocol of the study was registered at PROSPERO as CRD42016032933. A total of 1,328 articles were found; after selection, eight publications that met the study objective and inclusion criteria were selected, with information on 1,051,543 individuals. RESULTS: The results obtained in the meta-analyses indicate that women with cesarean section have a higher chance of maternal death (OR = 3.10, 95%CI 1.92–5.00) and postpartum infection (OR = 2.83, 95%CI, 1.585.06), but they have a lower chance of hemorrhage (OR = 0.52, 95%CI 0.48–0.57). For the blood transfusion outcome, the group effect was not associated with the type of delivery (95%CI 0.88–2.81). CONCLUSIONS: The quality of evidence was considered low for hemorrhage and blood transfusion and moderate for postpartum infection and maternal death. Thus, cesarean sections should be performed with caution and safety, especially when its benefits outweigh the risks of a surgical procedure.
Does the NEA Need Saving?
Authors: Wilbur Sarah
Published: November 2017

What are the stakes in saving the NEA, today? Departing from the recent legislative back-and-forth between President Donald Trump and Congress over the budgetary future of the National Endowment for the Arts (NEA), this performance analysis of the NEA’s 31 March 2017 meeting of the National Council on the Arts reveals the complex political posturing that undergirds federal support for the arts in US culture.
Three new species of Bathysciola Jeannel, 1910 (Leiodidae, Cholevinae, Leptodirini) from caves in Central Italy, comparing morphological taxonomy with molecular phylogeny
Authors: Latella Leonardo , Sbordoni Valerio , Allegrucci Giuliana
Published: November 2017

The genus Bathysciola is widely distributed in the northern Mediterranean region, although its range extends east to the Caucasus and Iran. More than 130 species belonging to this genus are actually known in the whole geographic distribution area and 45 species are distributed in continental and insular Italy. The species belonging to the Bathysciola sisernica
Cerruti and Patrizi, 1952 species group occur in the Central-Southern Italian Apennines and Pre-Apennines. This group consists of seven species, four of which (B. sisernica, B. delayi Latella and Rampini, 1994, B. rampinii
Latella, 2002, B. sbordoni Rampini and Latella, 1993) were already known to science and three are described herein, Bathysciola fabiolae
sp. nov., Bathysciola octaviani
sp. nov.

, and Bathysciola valeriae
sp. nov., markedly increasing the knowledge on the distribution of this genus in Central Italy. A morphological analysis was carried out based on diagnostic characters usually used to distinguish different taxa, and including both genitalia and external traits. Based on morphological characters, we reconstructed the phylogeny of this group of species, comparing them with the species belonging to other phyletic lineages, such as B. derosasi
Jeannel, 1914, B. georgi Cerruti, Patrizi, 1952, B. vignai Sbordoni and Rampini, 1978, and B. sarteanensis sarteanensis (Bargagli, 1870). Results suggested that morphological traits show a clear taxonomic signal but a poor phylogenetic signal. To better understand the relationships within this group of species, we performed a molecular analysis by sequencing three mitochondrial genes, 12S rRNA, 16S rRNA, partially sequenced and the entire gene of COI. Molecular markers were used to infer phylogenetic relationships among the Bathysciola sisernica species group and to reconstruct the historical processes that shaped their current geographic distribution. Results showed that these species became isolated in very ancient times, showing very high genetic differentiation.
Assessing China’s New Policy in Afghanistan
Authors: Umarov Akram
Published: November 2017

Prior to 2001, Beijing faithfully observed the principles of neutrality and non-interference regarding Afghanistan, yet it has become one of the key actors in appeasing the conflict, especially since 2014. Numerous scholars suggest that China’s U-turn is related to the potential threat posed by the Uygur separatists in Afghanistan. This study suggests an alternate motive; namely, that Afghanistan’s strategic location—the heart of Central and South Asia, the Middle East, and East Asia—drives China’s increased interest.
A new species of Macrosaccus (Lepidoptera: Gracillariidae: Lithocolletinae) from Arizona, USA
Authors: EISEMAN CHARLES S. , DAVIS DONALD R.
Published: November 2017

A sixth species of Macrosaccus (Gracillariidae), M. coursetiae sp. nov., is described. The larvae are leafminers of Coursetia glandulosa (Fabaceae). The parasitoid Chrysocharis walleyi (Eulophidae) has been reared from the leaf mines; a table summarizing the host records for this wasp is presented.
Ensemble Averaging and the Curse of Dimensionality
Authors: Christiansen Bo
Published: November 2017

When comparing climate models to observations, it is often observed that the mean over many models has smaller errors than most or all of the individual models. This paper will show that a general consequence of the nonintuitive geometric properties of high-dimensional spaces is that the ensemble mean often outperforms the individual ensemble members. This also explains why the ensemble mean often has an error that is 30% smaller than the median error of the individual ensemble members. The only assumption that needs to be made is that the observations and the models are independently drawn from the same distribution. An important and relevant property of high-dimensional spaces is that independent random vectors are almost always orthogonal. Furthermore, while the lengths of random vectors are large and almost equal, the ensemble mean is special, as it is located near the otherwise vacant center. The theory is first explained by an analysis of Gaussian- and uniformly distributed vectors in high-dimensional spaces. A subset of 17 models from the CMIP5 multimodel ensemble is then used to demonstrate the validity and robustness of the theory in realistic settings.
A Toolkit for Enhancing End-of-Life Care: An Examination of Implementation and Impact
Authors: Loeb Susan J. , Wion Rachel K. , Penrod Janice , McGhan Gwen , Kitt-Lewis Erin , Hollenbeak Christopher S.
Published: November 2017

The purpose of this study was to examine the infusion of a Toolkit for Enhancing End-of-Life Care in prisons, as well as the outcome and impact on the quality of prison end-of-life care. A total of 74 front-line staff and administrators were in attendance across two post-Toolkit-infusion evaluation visits. Applying qualitative analysis, co-researcher outcome findings were related to activities, community outreach and relations, multidisciplinary team, quality improvement approach, and participatory action research team effects. Organizational outcomes included barriers and challenges, cost, organizational features, sphere of influence, readiness (for change), and sustainability.
The Social Context of Driving Cessation: Understanding the Effects of Cessation on the Life Satisfaction of Older Drivers and Their Social Partners
Authors: Schryer Emily , Boerner Kathrin , Horowitz Amy , Reinhardt Joann P. , Mock Steven E.
Published: November 2017

Older adults with vision loss and a friend or family member were interviewed over a 2-year period. We examined the effects of driving cessation on life satisfaction among older adults and a social contact. Drivers’ use of public transportation was examined as a moderator. Driving cessation was associated with a decline in life satisfaction among social partners but not for the drivers. Drivers’ use of public transportation at baseline moderated the effects of cessation on changes in well-being among social partners, but had little effect on the life satisfaction of the drivers. Life satisfaction was greater among the social partners of ex-drivers who used public transportation more frequently. The association between driving cessation and well-being should be studied in the context of older drivers’ social networks. Infrastructure (e.g., subways and buses) that supports transportation needs plays an important role in mitigating the effects of cessation on older adults’ social networks.
Rhytidectomy After Parotidectomy
Authors: Paskhover Boris , Paul Benjamin C. , Rosenberg David B.
Published: November 2017

A history of prior parotidectomy is typically thought to substantially increase the risk of facial nerve injury for patients undergoing subsequent facelift surgery. For this reason, surgeons are often hesitant and may even elect not to perform facelift surgery on such patients. However, we have developed a safe and predictable operation for performing the post-parotidectomy rhytidectomy. Here, we present our rationale, approach, and results for performing this operation. This review is a retrospective case series. In total, 1200 facelifts from 2012 to 2016 performed by a single surgeon (D.B.R.) were reviewed. From these, 9 patients were identified as having had parotid surgery prior to rhytidectomy. Rhytidectomy was performed in 8 of 9 cases with a deep-plane, bilaminar approach. There were no intraoperative complications. One patient had a direct neck lift. There were no cases of revision. There were no cases of facial nerve damage including paresis or paralysis; 100% patient satisfaction was noted. Rhytidectomy with a deep-plane approach may be performed safely in patients who have undergone prior parotidectomy. Although there were no complications, revisions, postoperative asymmetry, or dissatisfaction in the patients in this study, it must be stressed that there is no substitute for a thorough appreciation of the surgical anatomy in combination with consideration of the changes to the surgical field that occur with parotid surgery.
Strapped for Time or Stressed Out? Predictors of Work Interruption and Unmet Need for Workplace Support Among Informal Elder Caregivers
Authors: Andersson Matthew A. , Walker Mark H. , Kaskie Brian P.
Published: November 2017

Objective: We evaluate whether strong associations between unmet need and work interruption observed among informal elder caregivers are explained by caregiver personal characteristics, caregiving situations, or diminished caregiver well-being. Method: We analyze a proprietary survey of informal elder caregivers conducted by a single large U.S. employer ( N = 642 caregivers). Results: Unmet need was about twice as common among those experiencing mild (29.79%) or severe interruption (35.00%) relative to those who did not interrupt work (16.87%). Although caregiver characteristics and aspects of caregiving situation show links to either unmet need or work interruption specifically, the association between unmet need and work interruption was not explained by these factors, or by caregiver well-being. Discussion: Needs-related work interruptions may arise by other workplace processes, such as organizational culture, that should be measured and tested explicitly by future research.
High incidence of extra-genital gonorrheal and chlamydial infections among high-risk men who have sex with men and transgender women in Peru
Authors: Allan-Blitz Lao-Tzu , Konda Kelika A , Calvo Gino M , Vargas Silver K , Leon Segundo R , Segura Eddy R , Caceres Carlos F , Klausner Jeffrey D
Published: November 2017

Extra-genital Neisseria gonorrhoeae and Chlamydia trachomatis infections are associated with antimicrobial resistance and HIV acquisition. We analyzed data from a cohort of men who have sex with men (MSM) and transgender women followed quarterly for two years in Peru. Incident cases were defined as positive N. gonorrhoeae or C. trachomatis nucleic acid tests during follow-up. Repeat positive tests were defined as reinfection among those with documented treatment. We used generalized estimating equations to calculate adjusted incidence rate ratios (aIRRs). Of 404 participants, 22% were transgender. Incidence rates of rectal N. gonorrhoeae and C. trachomatis infection were 28.1 and 37.3 cases per 100 person-years, respectively. Incidence rates of pharyngeal N. gonorrhoeae and C. trachomatis infection were 21.3 and 9.6 cases per 100 person-years, respectively. Incident HIV infection was associated with incident rectal (aIRR = 2.43; 95% CI 1.66–3.55) N. gonorrhoeae infection. Identifying as transgender versus cisgender MSM was associated with incident pharyngeal N. gonorrhoeae (aIRR = 1.85; 95% CI 1.12–3.07) infection. The incidence of extra-genital N. gonorrhoeae and C. trachomatis infections was high in our population. The association with incident HIV infection warrants evaluating the impact of rectal N. gonorrhoeae screening and treatment on HIV transmission.
Basic poly(propylene glycols) as reference compounds for internal mass calibration in positive-ion matrix-assisted laser desorption/ionization mass spectrometry
Authors: Gross Jürgen H
Published: November 2017

Basic poly(propylene glycols), commercially available under the trade name Jeffamine, are evaluated for their potential use as internal mass calibrants in matrix-assisted laser desorption/ionization-time-of-flight-mass spectrometry. Due to their basic amino endgroups Jeffamines are expected to deliver [M+H]+ ions in higher yields than neutral poly(propylene glycols) or poly(ethylene glycols). Aiming at accurate mass measurements and molecular formula determinations by matrix-assisted laser desorption/ionization-time-of-flight-mass spectrometry, four Jeffamines (M-600, M-2005, D-400, D-230) were thus compared. As a result, Jeffamine M-2005 is introduced as a new mass calibrant for positive-ion matrix-assisted laser desorption/ionization-time-of-flight-mass spectrometry in the range of m/z 200–1200 and the reference mass list is provided. While Jeffamine M-2005 is compatible with α-cyano-4-hydroxycinnamic acid, 2,5-dihydroxybenzoic acid, and 2-[(2 E)-3-(4- tert-butylphenyl)-2-methylprop-2-enylidene]malonitrile matrix, its use in combination with 2-[(2 E)-3-(4- tert-butylphenyl)-2-methylprop-2-enylidene]malonitrile provides best results due to low laser fluence requirements. Applications to PEG 300, PEG 600, the ionic liquid trihexyl(tetradecyl)-phosphonium tris(pentafluoroethyl)-trifluorophosphate, and [60]fullerene demonstrate mass accuracies of 2–5 ppm.
Median Nerve Injury After Removal of Subdermal Implantable Contraceptive
Authors: Christensen Joani M. , Caggiano Nicholas M. , Giladi Aviram M. , Iorio Matthew L.
Published: November 2017

Background: Subdermal implantable contraceptives are highly effective, approved in over 60 countries, and used by millions of women. Due to simple insertion and removal protocols, these procedures are often performed in the outpatient clinic setting, and procedural complications are rare. However, given the location of the implant in the medial antebrachial interval, there is a risk of neurovascular injury, especially with malpositioned or deeply placed implants. Methods: We present a case of proximal median nerve injury leading to severe neuropathy after attempted removal of a subdermal implantable contraceptive requiring neurolysis and tendon transfers. Results: At 6 months post surgery, the patient regained flexion of the index interphalangeal joints and protective sensation in the thumb and index fingers. Conclusions: Subdermal implant retrieval can lead to nerve injury, despite the relative simplicity of the procedure. If difficulty is encountered, imaging or open retrieval should be considered. Improvement in function can be gained through operative interventions including neurolysis and tendon transfers in the setting of severe neuropathy.
A Framework for Rethinking Educational Leadership in the Margins: Implications for Social Justice Leadership Preparation
Authors: Bertrand Melanie , Rodela Katherine C.
Published: November 2017

This article reimagines the social justice educational leadership field, highlighting the leadership of youth, parents, and community. We examine widely cited social justice educational leadership publications, in addition to critical research on youth voice, parent engagement, and community organizing. Our analysis reveals that the field often overlooks youth, parent, and community educational leadership. Through the theory of collective transformative agency, we propose a new framework for dismantling deficit ideologies and disempowering practices in leadership preparation programs. The article concludes with specific proposals for programs to re-envision the “how” and “who” of leadership preparation.
A process-oriented scale-up/scale-down strategy for industrial blown film processes: Theory and experiments
Authors: Neubert Benedikt , Dohm Christoph , Wortberg Johannes , Janßen Marius
Published: November 2017

To gain a competitive edge in developing innovative products, new multi-layer film manufacturers need to know whether laboratory-scale blown film line results reliably translate to large-scale production. This, however, is not always the case: Transferring process conditions and getting equal final film properties are not ensured. To address this problem, this paper presents a scale-independent scale-up/scale-down strategy to produce films with consistently similar properties regardless of a plant’s size and design. A second aim is to prove this strategy is applicable by comparing the reference and experimental film mechanical properties. Here, experimental scale-down runs were carried out based on a process-oriented scale-up/scale-down strategy for the blown film process. An industrial production process (>800 kg/h), successfully transferred to a laboratory-scale blown film line, was used as the reference. The introduced process-oriented scale-up/scale-down is based on geometric and dynamic similarity. In this context, blow-up ratio, draw-down ratio and process time have been identified as major scale-up/scale-down variables. Unlike existing scale-up strategies, the process-oriented approach is more flexible in practice. Film mechanical properties taken from the experimental runs were determined by tensile and puncture resistance tests. The compared results confirmed that process-oriented scale-up/scale-down is feasible for the applied material and under the existing plant-specific restrictions. The comparison indicated that most film properties produced on the laboratory-scale plant were comparable to those from the high-capacity blown film line.
Development and Validation of a Novel Integrated Clinical-Genomic Risk Group Classification for Localized Prostate Cancer
Authors: Spratt Daniel E. , Zhang Jingbin , Santiago-Jiménez María , Dess Robert T. , Davis John W. , Den Robert B. , Dicker Adam P. , Kane Christopher J. , Pollack Alan , Stoyanova Radka , Abdollah Firas , Ross Ashley E. , Cole Adam , Uchio Edward , Randall Josh M. , Nguyen Hao , Zhao Shuang G. , Mehra Rohit , Glass Andrew G. , Lam Lucia L.C. , Chelliserry Jijumon , du Plessis Marguerite , Choeurng Voleak , Aranes Maria , Kolisnik Tyler , Margrave Jennifer , Alter Jason , Jordan Jennifer , Buerki Christine , Yousefi Kasra , Haddad Zaid , Davicioni Elai , Trabulsi Edouard J. , Loeb Stacy , Tewari Ashutosh , Carroll Peter R. , Weinmann Sheila , Schaeffer Edward M. , Klein Eric A. , Karnes R. Jeffrey , Feng Felix Y. , Nguyen Paul L.
Published: November 2017

Purpose

It is clinically challenging to integrate genomic-classifier results that report a numeric risk of recurrence into treatment recommendations for localized prostate cancer, which are founded in the framework of risk groups. We aimed to develop a novel clinical-genomic risk grouping system that can readily be incorporated into treatment guidelines for localized prostate cancer.

Materials and Methods

Two multicenter cohorts (n = 991) were used for training and validation of the clinical-genomic risk groups, and two additional cohorts (n = 5,937) were used for reclassification analyses. Competing risks analysis was used to estimate the risk of distant metastasis. Time-dependent c-indices were constructed to compare clinicopathologic risk models with the clinical-genomic risk groups.

Results

With a median follow-up of 8 years for patients in the training cohort, 10-year distant metastasis rates for National Comprehensive Cancer Network (NCCN) low, favorable-intermediate, unfavorable-intermediate, and high-risk were 7.3%, 9.2%, 38.0%, and 39.5%, respectively. In contrast, the three-tier clinical-genomic risk groups had 10-year distant metastasis rates of 3.5%, 29.4%, and 54.6%, for low-, intermediate-, and high-risk, respectively, which were consistent in the validation cohort (0%, 25.9%, and 55.2%, respectively). C-indices for the clinical-genomic risk grouping system (0.84; 95% CI, 0.61 to 0.93) were improved over NCCN (0.73; 95% CI, 0.60 to 0.86) and Cancer of the Prostate Risk Assessment (0.74; 95% CI, 0.65 to 0.84), and 30% of patients using NCCN low/intermediate/high would be reclassified by the new three-tier system and 67% of patients would be reclassified from NCCN six-tier (very-low– to very-high–risk) by the new six-tier system.

Conclusion

A commercially available genomic classifier in combination with standard clinicopathologic variables can generate a simple-to-use clinical-genomic risk grouping that more accurately identifies patients at low, intermediate, and high risk for metastasis and can be easily incorporated into current guidelines to better risk-stratify patients.
Nova esquerda social-liberal
Authors: Pereira Luis Carlos Bresser
Published: November 2017

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A Medida Provisória: ontem, hoje e amanhã
Authors: Tácito Caio
Published: November 2017

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Licitações e contratos e na emenda constitucional nº 19/98
Authors: Mukai Toshio
Published: November 2017

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Participação privada nos serviços de limpeza urbana
Authors: Pereira Cesar Augusto Guimarães
Published: November 2017

I - Definição do Tema; II- Delimitação dos Serviços de Limpeza Urbana; III - Noção de Serviço Público: Atividades Competitivas e Atividades Não Competitivas; IV - Aplicação da Noção de Serviço Público às Atividades de Limpeza Urbana; V - A Configuração Atual da Concessão de Serviços de Limpeza Urbana no Brasil; VI - Competência Administrativa no Caso de Serviços Transmunicipais; VII - Possibilidade de Identificação do Usuário como Requisito da  oncessão; VIII - Natureza das Cobranças do Concessionário; IX - O Problema do Inadimplemento dos Usuários; X - Conclusão.
A concessão, pela União, de isenções de tributos estaduais e municipais - Possibilidade no âmbito dos tratados internacionais
Authors: Gusmão Daniela Ribeiro de
Published: November 2017

Introdução - Itaipu BinacionaL e o gasoduto Brasil-Bolívia - Soberania e autonomia - União X Estado Federal- Lei nacionaL X lei federal - O artigo 98 do Código Tributário Nacional - Tratados-contrato X tratados-lei - Vedação constitucional à concessão de isenções heterônomas - A isenção heterônoma no âmbito internacional - Isenções relativas ao ICMS e ISS - Conclusão - Bibliografia
Agências reguladoras
Authors: Souto Marcos Juruena Villela
Published: November 2017

1. As agências autônomas na Reforma do Estado - 2. Distinção entre agência reguladora e agência executiva - 3. Função regulatória - 3.1. Noção de Regulação - 3.3. A regulação como instrumento da Desestatização - 3.3. A regulação no Brasil - 3.3.1. A regulação sem órgãos reguladores independentes - 3.3.2. A regulação por agências reguladoras - 4. Natureza jurídica da agência reguladora - 5. Criação e extinção da agência reguladora - 5.1. Criação e extinção da agência - 5.2. Impacto da extinção sobre os contratos - 6. Competência da agência reguladora - 6.1. Conflitos de competências - 6.2. Conflitos entre agências que exercem o poder concedente - 7. Estrutura da agência reguladora - 8. Dirigentes e Pessoal da agência reguladora - 8.1. Regime jurídico dos dirigentes - 8.2. Perda do cargo de dirigente - 8.3. Composição de quadros - 9. Receita do órgão regulador - 9.1. Natureza jurídica da taxa de regulação - 10. Contratos celebrados pela agência de regulação - 11. Fiscalização sobre a agência de regulação - 12. Processo administrativo - 13. As agências no âmbito federal - 13.1. Petróleo - 13.2. Telecomunicações - 13.3. Energia Elétrica - 13.4. Transportes - 14. As agências no âmbito estadual - 14.1. Estado do Rio de Janeiro - 14.2. Estado de São Paulo - 14.3. Estado do Ceará - 14.4. Estado do Rio Grande do Sul- 14.5. Estado de Sergipe - 15. Experiências de regulação no Direito Comparado - 16. Conclusão
IPTU - Progressividade - Inconstitucionalidade
Authors: Brindeiro Geraldo
Published: November 2017

Supremo Tribunal Federal
Servidor celetista - Conversão - Direito adquirido
Authors: Sanches Sydney
Published: November 2017

- Servidor celetista convertido em servidor estatutário tem direito adquirido à contagem de tempo de serviço para perceber adicional (anuênio) e licença prêmio.
Servidor público - Isonomia - Súmula nº 339
Authors: Pereira Miguel Frauzino
Published: November 2017

- Esta Corte, como demonstram os precedentes invocados no parecer da Procuradoria-Geral da República, já firmou o entendimento de que continua em vigor, emface da atual Constituição, a súmula 339 ("Não cabe ao Poder Judiciário, que não tem função legislativa, aumentar vencimentos de servidores públicos, sob fundamento de isonomia"), porquanto o § 1°. do artigo 39 da Carta Magna é preceito dirigido ao legislador; a quem compete concretizar o princípio da isonomia, considerando especificamente os casos de atribuições iguais ou assemelhadas, não cabendo ao Poder Judiciário substituir-se ao legislador. Contra lei que viola o princípio da isonomia é cabível, no âmbito do controle concentrado, ação direta de inconstitucionalidade por omissão, que, se procedente, dará margem a que dessa declaração seja dada ciência ao Poder Legislativo para que aplique, por lei, o referido princípio constitucional; já na esfera do controle difuso, vício dessa natureza só pode conduzir à declaração de inconstitucionalidade da norma que infringiu esse princípio, o que, eliminando o benefício dado a um cargo quando deveria abranger também outros com atribuições iguais ou assemelhadas, impede a sua extensão a estes. Recurso extraordinário conhecido e provido.
Informática - Ano 2000 - Defesa do Consumidor
Authors: D'albuquerque Júnior Nelson Faria Lins
Published: November 2017

- Garantia do consumidor contra vícios de equipamentos de informática a partir do ano 2000
Dívida ativa - Inscrição - Competência
Authors: Saraiva Filho Oswaldo Othon de Pontes
Published: November 2017

Advocacia Geral da União.
Contrato administrativo - Limites - Alteração excepcional
Authors: Saraiva Iram
Published: November 2017

- É admissível alteração de contrato administrativo acima dos limites legais, a título excepcional, se nova licitação e contratação importam sacrifício insuportável ao interesse público primário.
Comissões Parlamentares de inquérito - Competências - Contrato privado
Authors: Barroso Luis Roberto
Published: November 2017

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Supermercados - Etiquetagem de preços - Princípio de legalidade
Authors: Grau Eros Roberto
Published: November 2017

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Processo legislativo - Veto parcial - Cabimento (Governo do Estado do Rio de Janeiro)
Authors: Desconhecido Desconhecido
Published: November 2017

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Leis, Leis Complementares e Decretos (1999)
Authors: Desconhecido Desconhecido
Published: November 2017

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Comissão parlamentar de inquérito - Poderes - Limites
Authors: Mello Celso Antônio Bandeira de
Published: November 2017

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Comissão parlamentar de inquérito - Poder de investigação - Limites
Authors: Mello Celso Antônio Bandeira de
Published: November 2017

- Os poderes de investigação atribuídos à comissão parlamentar de inquérito não são absolutos e comportam limitações, submetendo-se ao controle jurisdicional.- As comissões parlamentares de inquérito podem decretar, por autoridade própria, a quebra de sigilo bancário de pessoas por elas investigadas, desde que justifiquem a existência concreta de causa provável legitimadora da medida excepcional e indiquem a necessidade de sua efetivação no procedimento de ampla investigação.
Tribunal de Contas - Franquia - Competência
Authors: Saraiva Iram
Published: November 2017

- Contratos de franquia comercial sobre Correios é matéria de direito privado que não cabe no controle do Tribunal de Contas.
Legitimidade ativa para controle concentrado de constitucionalidade - Imunidade tributária das entidades sindicais
Authors: Martins Ives Gandra da Silva
Published: November 2017

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Comissão Parlamentar de Inquérito - Prazo certo - Extinção
Authors: Tácito Caio
Published: November 2017

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Banco Central - Pessoal - Regime Jurídico
Authors: Borja Célio
Published: November 2017

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Agência administrativas, poder regulamentar e o Sistema Financeiro Nacional
Authors: Moreira Egon Bockmann
Published: November 2017

I. Premissas hermenêuticas. II. As agências administrativas e o direito brasileiro. III. Conselho Monetário Nacional, Banco Central do Brasil e Comissão de Valores Mobiliários - Natureza Jurídica. IV. Função regulamentar. V. Função regulamentar de CMN, BACEN e CVM, emfacedas Agências. VI. Conclusão.
Servidor Estadual - Aumento de remuneração - Inconstitucionalidade
Authors: Mello Celso Antônio Bandeira de
Published: November 2017

1. São inconstitucionais dispositivos de Cartas Estaduais, inclusive Emendas, que concedam aumento de remuneração a servidores públicos ou que, de qualquer modo, acarretem majoração da despesa pública, por ser da competência exclusiva do Chefe do Poder Executivo a iniciativa de lei sobre a matéria. Precedentes.2. Diversa da correção monetária, cujo instituto objetiva tão-somente a reposição do poder aquisitivo, a multa estabelecida no § 31º acrescentado ao artigo 137 da Carta Estadual pela Emenda Constitucional nº 11/99 representa penalidade imposta ao Estado e redunda em aumento na remuneração do servidor público sempre que ocorrer atraso na folha de pagamento.3. É inconstitucional a norma de lei local que vincula a índice federal o cálculo de despesa com servidores públicos estaduais. Precedentes.4. São de competência da União a definição jurídica de crime de responsabilidade e a regulamentação dos respectivos processo e julgamento.Precedente.Pedido de liminar deferido.
Tribunal de Contas Estadual - Provimento - Governador
Authors: Corrêa Maurício
Published: November 2017

- Ação Direta de Inconstitucionalidade. Tribunal de Contas Estadual: Organização e composição. Constituição do Estado do Piauí (artigo 88, § 2º, I e 11). Leis nºs. 4.721/94 (artigo 81, I e II) e 5.056/99 (artigos 2º e 3º, I e II) ambas do Estado do Piauí.- Ofende a Constituição Federal a norma estadual (constitucional ou infra constitucional) que altera a possibilidade de o Governador indicar dois nomes para prover os cargos de conselheiro do Tribunal de Contas do Estado, alternadamente, entre auditores e membros do Ministério Público, além de um terceiro de sua livre escolha.- Sendo o Tribunal de contas do Estado integrado por sete conselheiros, três devem ser escolhidos pelo governador e quatro pela Assembléia legislativa. Precedentes.- Pedido de liminar deferido.
Professor - Tempo de serviço - Estabilidade
Authors: Aurélio Marco
Published: November 2017

- Longe fica de vulnerar o art. 19 do Ato das Disposições Transitórias da Carta de 1988 preceito de Diploma Maior Local a encerrar a consideração, como contínuo, de tempo de serviço prestado por professores que, ao término de cada alio letivo, eram "dispensados" para contratação imediata no início do alio letivo seguinte. Entre as interpretações possíveis, deve ser afastada aquela discrepante da realização do trinômio Lei-Direito-Justiça.
Federalismo, flexibilidade e assimetria no direito brasileiro: agrupamentos municipais, convênios de cooperação e consórcios públicos
Authors: Pires Thiago Magalhães
Published: November 2017

O objetivo do presente estudo é investigar se uma concepção flexível e cooperativa do pacto federativo não seria mais adequada do que a tradicional rigidez que o caracteriza para acomodar o caráter dinâmico das federações, bem como a inevitável assimetria entre seus componentes. Na sequência, examinam-se três mecanismos de ajuste e cooperação já existentes no Brasil e capazes, em princípio, de incorporar essa flexibilidade à federação brasileira: agrupamentos municipais, convênios de cooperação e consórcios públicos. This paper aims to determine if a flexible and cooperative conception of federalism would be more capable to accommodate the dynamics of federal states, as well as the inevitable asymmetry between its components. The article then analyses three instruments of adjustment and cooperation that already exist in Brazil, and that are likely able to incorporate this flexibility to the Brazilian federation: local-government associations, cooperation agreements and public consortia.
A inarbitrabilidade objetiva do conflito entre Petrobras e a ANP
Authors: Baptista Patrícia Ferreira
Published: November 2017

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Negociação de sinal de TV por assinatura
Authors: Macedo Conselheiro Alexandre Cordeiro
Published: November 2017

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Parecer do caso Vale
Authors: Vieira Jorge Hilário Gouvêa
Published: November 2017

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PERSPECTIVE INTROGRESSIVE LINES OF SOFT SPRING WHEAT WITH AGROPYRON ELONGATUM GENES SUSTAINABLE TO SEPTORIOUS IN WESTERN SIBERIA
Authors: Плотникова Людмила , Plotnikova Lyudmila , Сагындекова Айнура , Sagyndekova Aynur , Бережкова Галина , Berezhkova Galina
Published: November 2017

In Western Siberia, the resistance to septoria was tested for samples of wheatgrass of elongated Agropyron elongatum and introgressive lines of spring soft wheat with its genes, created at Omsk State Agrarian University. The experiments were conducted in the field in the forest-steppe zone of the south of Western Siberia (Omsk) in 2013-2016 on an annual natural infectious background. In 2013, the manifestations of septoriosis were weak, in 2014-2015 - moderate, and in 2016 epiphytoty was spread, which led to a severe defeat of varieties of West Siberian selection. A. elongatum samples showed immunity to the disease. In 2013, 15 promising wheat lines were identified that showed high or medium resistance to the Septoria tritici fungus, causing leaf spotting, and Parastagonospora nodorum, which affects leaves and spikes. The lines were predominantly in the middle or middle groups. According to the results of four-year experiments in contrasting weather conditions, the best lines on average showed higher productivity than, or comparable to, the standard varieties, mainly due to the increased number of productive stems of the plant and a high mass of 1000 grains. During the period of observation, there was an increase in the damage of wheat varieties and lines by the causative agents of Septoria, especially S. tritici. In 2013, 8 lines showed high resistance to leaf damage, 10 lines - ears. During the epiphytosis of 2016 year the resistance to S. tritici retained only 2 lines. The resistance to damage to the ear was more stable, in 2016, 6 lines were high, and 5 - medium resistant to P. nodorum. Two lines showed high resistance to septoriosis of leaves and ear. Dedicated lines are recommended for use in breeding soft wheat for resistance to disease.
EVALUATION OF ALBIT APPLICATION EFFICIENCY ON WINTER WHEAT IN THE REPUBLIC OF TATARSTAN
Authors: Сафин Радик , Safin Radik , Колесар Валерия , Kolesar Valeriya , Березин Константин , Berezin Konstantin
Published: November 2017

The effect of application of the Albit preparation during autumn spraying in pure form and in a mixture with fungicides was studied. It was found that the use of Albit promotes the growth of plant conservation during wintering of wheat plants and reduces the root rot development of winter wheat.
In combination with benzimidazole fungicides this effect was enhanced. The maximum crop productivity - 3.75 tons per hectare was in the use of Albit + Ferezyme mixture in combination with Vial Trust seed treatment.
As a result of the use of Albit, there was an increase in the content of gluten in the grain. The use of this method has increased the economic efficiency of wheat cultivation.
AGROTECHNICAL ASPECTS OF THE WORKING UNIT APPLICATION FOR UNDERGROUND SOIL TREATMENT
Authors: Салахов Ильнур , Salakhov Ilnur
Published: November 2017

Abstract. The subsoiling tillage is aimed at weakening the surface runoff of water and transferring it to the subsurface. The main methods of non-plowing treatment are subsoiling, flat and chisel processing, milling, chinking, deepening of the arable layer of the soil. However, the working units of existing tools for subsoiling tillage do not provide sufficient accumulation and preservation of moisture in the soil, its optimum density for the development of the root system of plants, and are characterized by increased energy intensity. This article presents the agrotechnical aspects of subsoiling, which contributes to a decrease in the development of erosion processes and an increase in moisture accumulation in the soil in conditions of a deficiency in soil moisture. The description of the soil-cultivating tool with working units of drive action is given. The results of the influence of the proposed treatment method on the agrotechnical indices of the soil are obtained.
RUSSIAN AGRICULTURE IN THE CONDITIONS OF IMPORT SUBSTITUTION
Authors: Захарова Галина , Zakharova Galina
Published: November 2017

Economic instability, a decline in investment activity, an acceleration in the rate of inflation, and in part the inability of domestic producers to resist competitors from abroad, predetermined the need for fundamental qualitative changes in the economic policy of the country. In business, there is a golden rule of success: use any problem as a chance to improve something and reach a new level of development. Thus, the import substitution method was proposed, which also affected agriculture. The rapidly changing macroeconomic conditions (the necessity for import substitution of agricultural products in a short time in conditions of limited trade with individual countries, the change in the support system in the EU since 2015, the continuing weakening of the national currency) have set new tasks for agriculture. The article presents an analysis of the results of agriculture functioning under conditions of import substitution.
PROBLEMS IN THE RUSSIAN IMPORT SUBSUMPTION SYSTEM
Authors: Кириллова Ольга , Kirillova Olga
Published: November 2017

Nowadays, anti-Russian sanctions, imposed by the EU and the USA, have a special impact on the agrifood market. This enabled domestic producers to establish profitable production of pig breeding, vegetable growing, plant growing, etc. This can be facilitated by a program to subsidize interest rates on investment loans for the construction and modernization of complexes for the maintenance of animals, farms and the purchase of breeding animals. High competitiveness of products and quick payback will lead to an increase in the level of investment in the industry. The main problem of full-fledged use of such programs is the lack of money in the state budget and the high state debt on investment loans. The income of agricultural producers is greatly influenced by the constant decrease in the incomes of agricultural consumers and, consequently, the decrease in demand for agricultural products. Falsification of food products has a special impact on the agricultural products market. Problems for the agro-industrial complex continue to remain: the modernization of production and technology, the provision of highly qualified specialists in the agricultural sectors. An important issue is the resource map of the regions, which is the study of each region separately in terms of using its competitive advantages. This will significantly increase the level of socio-economic growth of the country, because competitive advantages of each territory will be involved. Under the tightening of sanctions, Russia will not be able to completely replace imports with domestic products in the coming years. To a large extent this is due to a shortage of production capacity. Therefore, it is necessary to apply the strategy of export-oriented import substitution, which is connected with increasing the competitive advantages of domestic production. A full application of import substitution in Russia will be unprofitable for the economy and will be associated with increased inflation, a decrease in savings, a reduction in investment activity, a deficit in the balance of payments.
IMPACT OF INFORMATION TECHNOLOGY DEVELOPMENT ON METHODOLOGY OF SMALL ENTERPRISES ACCOUNTING
Authors: Фахретдинова Эльвира , Fakhretdinova Elvira , Клычова Гузалия , Klychova Guzaliya
Published: November 2017

At the present stage, the efficiency of enterprise development is largely determined by the level of information technologies use in the business. The use of computer-aided information processing also affects the methodology of accounting, dictates the need to use an electronic document (created with the help of computer-aided information processing and signed by an electronic signature), electronic document flow (electronic creation, transfer and archiving of documents on the computer in the form of file of the appropriate format, as well as control over their implementation and protection from unauthorized access), forms of accounting.
Returns to Emergency Department, Observation, or Inpatient Care Within 30 Days After Hospitalization in 4 States, 2009 and 2010 Versus 2013 and 2014
Authors: Nuckols Teryl K. , Fingar Kathryn R. , Barrett Marguerite L. , Martsolf Grant , Steiner Claudia A. , Stocks Carol , Owens Pamela L.
Published: November 2017

BACKGROUND

Nationally, readmissions have declined for acute myocardial infarction (AMI) and heart failure (HF) and risen slightly for pneumonia, but less is known about returns to the hospital for observation stays and emergency department (ED) visits.

OBJECTIVE

To describe trends in rates of 30‐day, all‐cause, unplanned returns to the hospital, including returns for observation stays and ED visits.

DESIGN

By using Healthcare Cost and Utilization Project data, we compared 210,007 index hospitalizations in 2009 and 2010 with 212,833 matched hospitalizations in 2013 and 2014.

SETTING

Two hundred and one hospitals in Georgia, Nebraska, South Carolina, and Tennessee.

PATIENTS

Adults with private insurance, Medicaid, or no insurance and seniors with Medicare who were hospitalized for AMI, H F, and pneumonia.

MEASUREMENTS

Thirty‐day hospital return rates for inpatient, observation, and ED visits.

RESULTS

Return rates remained stable among adults with private insurance (15.1% vs 15.3%; P = .45) and declined modestly among seniors with Medicare (25.3% vs 25.0%; P = .04). Increases in observation and ED visits coincided with declines in readmissions (8.9% vs 8.2% for private insurance and 18.3% vs 16.9% for Medicare, both P ≤ .001). Return rates rose among patients with Medicaid (31.0% vs 32.1%; P = .04) and the uninsured (18.8% vs 20.1%; P = .004). Readmissions remained stable (18.7% for Medicaid and 9.5% for uninsured patients, both P > .75) while observation and ED visits increased.

CONCLUSIONS

Total returns to the hospital are stable or rising, likely because of growth in observation and ED visits. Hospitalists' efforts to improve the quality and value of hospital care should consider observation and ED care.