bluuebunny/crossref_metadata_2025 huggingface dataset:
Modern technologies enable treatment planning and the fabrication of clear aligners for the correction of misaligned teeth
Authors: Fekonja Anita , Rošer Nejc , Drstvenšek Igor
Published: September 2022

Namen: Namen prispevka je predstaviti možnost poravnave zob z estetskimi prozornimi opornicami, ki jo omogoča tehnologija, v celoti izvedena v Sloveniji.

Poročilo o primeru: 34-letni pacient je obiskal specialistično ambulanto zaradi nepravilnega položaja zob v spodnji čeljustnici. Cilj zdravljenja je bil poravnati zobe v spodnjem zobnem loku z uporabo prozornih opornic, izdelanih v Sloveniji. Postopek smo začeli s kakovostnim odtisom za delovni model. Delovni model smo skenirali in tako v računalniku ustvarili 3D različico pacientovih zobnih lokov in griza. S pomočjo programske opreme smo izdelali 3D navidezni model in na njem zobe premaknili v želen (optimalen) položaj, ki naj bi ga dosegli z opornicami. Opornice smo izdelali iz termoplastičnega materiala (poliuretan) s termo-formiranjem, in sicer s pomočjo modela, izdelanega z laserskim sintranjem. Pacient je prejel navodila o 22-urni dnevni nošnji, vsako opornico zamenja po 2 tednih. Obravnava je trajala 6 mesecev. Ob koncu zdravljenja je bil nameščen fiksni retencijski lok za stabilizacijo in preprečitev recidiva. Pacient je z rezultatom bil zelo zadovoljen. Dve leti po zaključenem zdravljenju stanje ostaja nespremenjeno in stabilno.

Zaključek: Zdravljenje s prozornimi opornicami je v primerjavi s klasičnimi fiksnimi aparati snemljiva tehnika, ki zagotavlja boljšo estetiko, večje udobje, omogoča boljše vzdrževanje higiene.
Ewolucja szwedzkiego „prawa gospodarczego”
Authors: Sagan Beata , Sagan Stanisław
Published: September 2022

Opracowanie zostało poświęcone ewolucji szwedzkiego „prawa gospodarczego”. Tak określona gałąź prawa formalnie bowiem w Szwecji nie istnieje. Rozwój „prawa gospodarczego” w tym kraju wywodzi się z prawa umów, a współcześnie, od lat siedemdziesiątych XX stulecia, dostrzega się rozwój prawa handlowego i gospodarczego.

Celem artykułu jest charakterystyka podstawowych aktów normatywnych, które tworzą fundament szwedzkiego prawa umów oraz prawa handlowego i gospodarczego. Z natury praktyczni Szwedzi równolegle do rozwoju ustawodawstwa powołali organy i instytucje, które pozwalają na instytucjonalną ochronę praw konsumenta i dobrych praktyk w handlu i usługach. To wyjątkowo efektywny i sprawny mechanizm, który pozwala na rozstrzyganie większości spraw spornych w gospodarce w sposób polubowny.

Obecnie najbardziej dynamicznie rozwija się ta część szwedzkiego „prawa gospodarczego”, która wiąże się z prawem ochrony konsumentów i prawem konkurencji. Równolegle doskonalone jest pozasądowe rozstrzyganie sporów między podmiotami gospodarczymi a konsumentami.
Wspólne inspekcje organów administracji państw członkowskich UE
Authors: Kowalczyk Barbara , Prus Łukasz
Published: September 2022

Artykuł dotyczy wspólnych inspekcji przeprowadzanych przez organy państw członkowskich w UE w ramach współpracy administracyjnej. Można je określić mianem operacji transgranicznych, które należy rozumieć jako działania wykonawcze (stosowanie, egzekwowanie prawa), podczas których urzędnicy (pracownicy, funkcjonariusze) z jednego państwa członkowskiego UE (współ)działają na terytorium innego państwa. Współpraca transgraniczna jest wyrazem wspólnej (dzielonej) odpowiedzialności państw członkowskich za zapewnienie efektywnego wykonywania prawa UE.
Reglamentacja dostępu do pasa drogowego a koszty przełożenia sieci na drogach publicznych
Authors: Sobieralski Krzysztof
Published: September 2022

Pas drogowy jako jeden ze składników majątku publicznego podlega szczególnej ochronie, która wyraża się w reglamentacji wykorzystywania go na cele inne niż potrzeby zarządzania drogą lub potrzeby ruchu drogowego. Wyrazem tej reglamentacji jest konieczność uzyskania zezwolenia na zajęcie pasa drogowego, a więc uchylenia generalnego zakazu w indywidualnym przypadku. Przy tym podmiot posiadający stosowne zezwolenie na zajęcie pasa drogowego nie ma pełni praw do tego składnika majątku publicznego, a jedynie tak zwane prawo na rzeczy cudzej. Wynika z tego wiele konsekwencji praktycznych.
Idea synergicznego i permanentnego zarządzania jakością (total quality management) — geneza, cele i zasady
Authors: Wiśniewska-Paź Barbara
Published: September 2022

Problematyka związana z zarządzaniem, jakością i kompetencjami przynajmniej od kilku dekad cieszy się bardzo dużym zainteresowaniem i jest przedmiotem analiz przedstawicieli różnych dyscyplin naukowych. Są one interesujące, bo dotyczą niemal każdej dziedziny naszego życia — ich rozwoju, a jednocześnie problemów do rozwiązania, wdrożenia innowacji oraz nieustannego przy tym uwzględniania kontekstu zmian społeczno-kulturowych, gospodarczych, technologicznych i innych. Jest to zdaniem Andrzeja Bliklego uniwersalna metoda, której celem jest podnoszenie efektywności funkcjonowania zespołów ludzkich w różnego typu instytucjach, w tym biznesowych, samorządowych, administracji publicznej, szkolnictwie, służbach czy wojsku.

Zarządzanie poprzez jakość (ang. total quality management) dotyczy projakościowego podejścia do życia i pracy, opartego na współpracy, zaangażowaniu, uważności, samokontroli oraz potrzebie rozwoju i podnoszenia własnych kwalifikacji i kompetencji. Ma to docelowo wpływać na długofalowy rozwój, ale i dobrostan zarówno pracowników, instytucji, jak i potencjalnych petentów, klientów oraz szerokiego zespołu instytucji i osób korzystających z usług firmy/instytucji lub prowadzących z nią współpracę (w ramach różnych przestrzeni rzeczywistości społecznej, kulturowej, gospodarczej, edukacyjnej itp.), a także społeczeństwa rozumianego w jego rozmaitych wymiarach.

Artykuł traktuje o kluczowych wymiarach i kontekstach koncepcji kompleksowego zarządzania jakością.
Specyfika definiowania „przesłanek ograniczania” działalności gospodarczej na przykładzie zakazu reklamy aptek i punktów aptecznych
Authors: Jabłoński Mariusz
Published: September 2022

W opracowaniu poruszono kwestię „mechanizmu” definiowania przesłanek, których uwzględnienie przez ustawodawcę doprowadziło do wprowadzenia zakazu reklamy aptek i punktów aptecznych w ujęciu aktualnie obowiązującego art. 94a ust. 1 ustawy — Prawo farmaceutyczne.
Decyzja o środowiskowych uwarunkowaniach i jej znaczenie z punktu widzenia gospodarki złożami kopalin
Authors: Wojtulek Piotr
Published: September 2022

Decyzja o środowiskowych uwarunkowaniach jest instrumentem oceny wpływu planowanych inwestycji na środowisko. Jej waga dostrzegalna jest zwłaszcza w przedsięwzięciach znacznie oddziałujących na środowisko, do których zaliczają się inwestycje regulowane w ustawie z dnia 9 czerwca 2011 roku — Prawo geologiczne i górnicze. W postępowaniach administracyjnych, przede wszystkim koncesyjnych, regulowanych tą ustawą decyzja ta stanowi rozstrzygnięcie prejudycjalne warunkujące wydanie koncesji. W dobie transformacji energetycznej, która zmienia priorytety w gospodarce surowcami mineralnymi, decyzja o środowiskowych uwarunkowaniach zyskuje także funkcję instrumentu regulacji zarządzania złożami kopalin. Istotne znaczenie w tym procesie ma również udział społeczeństwa w postępowaniu o ocenie oddziaływania na środowisko.
Heterogeneidade Molecular da Deficiência em Glicose-6-Fosfato Desidrogenase (G6PD) na População Portuguesa
Authors: Manco Licínio , Bento Celeste , Relvas Luís , Maia Tabita , Ribeiro Maria Letícia
Published: September 2022

Introdução: A deficiência de glicose-6-fosfato desidrogenase (G6PD) é o defeito enzimático mais comum no mundo, afetando mais de 500 milhões de pessoas. Em Portugal, a frequência populacional da deficiência de G6PD no sexo masculino foi estimada em cerca de 0,5%, e desde o ano 2000 têm vindo a ser descritas diversas variantes G6PD causadoras da deficiência. O principal objetivo deste estudo foi melhorar o conhecimento sobre a heterogeneidade molecular da deficiência de G6PD na população portuguesa.Material e Métodos: Análise retrospetiva do perfil mutacional de 138 indivíduos não-aparentados de naturalidade portuguesa (101 homens e 37 mulheres), sem ascendência subsaariana conhecida, diagnosticados com deficiência de G6PD entre 1994 e 2020 na Unidade de Hematologia Molecular do Centro Hospitalar e Universitário de Coimbra (CHUC). O estudo molecular foi feito por sequenciação direta de Sanger ou análise por PCR-RFLP.Resultados: Identificaram-se 21 mutações patogénicas diferentes. Destas, 20 são mutações missense, que levam à troca de aminoácido, e uma é uma deleção in-frame de 18 nucleótidos no exão 10. As três mutações mais frequentes pertencem ao haplótipo subsaariano G6PD c.376A>G, nomeadamente as variantes G6PD: A- (c.202G>A; p.68Val>Met) (58,6%), Betica (c.968T>C; p.323Leu>Pro) (12,1%) e Santamaria (c.542A>T; p.181Asp>Val) (4,3%).Conclusão: Existe uma elevada heterogeneidade molecular da deficiência de G6PD em Portugal.
A hidra do Iguaçu
Authors: Miranda Cristiana
Published: September 2022

A partir de uma experiência cinematográfica desenvolvida pela própria autora, por meio do resgate de memórias em cidades coloniais, reflete-se sobre o processo poético de buscar as linhas escondidas por trás das narrativas oficiais, valendo-se de um percurso etnográfico que redesenha um triângulo colonial imaginado.
Apresentação
Authors: Aldrin Aldrin Moura de , Knauss Paulo
Published: September 2022

Tomando como ponto de partida as diferentes narrativas sobre a efeméride do bicentenário da Independência do Brasil (1822), em conexão com outros marcos históricos relacionados ao longo do tempo, como por exemplo os debates em torno da Semana de Arte Moderna, em 1922, este dossiê busca apresentar diferentes histórias conectadas e cruzadas, em distintas escalas de leitura temporal e espacial, acerca da tradição e da modernidade no Brasil. Assunto prolixo, porém inesgotável, o evento histórico é tratado aqui como uma janela para a compreensão das relações entre passado e presente no campo da arte.
Geórgicas 2.490-542 e a paradoxal agricultura
Authors: Muniz Liebert Abreu
Published: September 2022

A matéria agrária das Geórgicas insere o segundo poema de Virgílio, composto em ca. 37-30 a.C., entre os textos técnicos latinos. Filiado à tradição hesiódica, o poema traz o tripé característico do gênero: o mestre, a matéria e o discípulo. Além disso, o momento histórico em que o poema foi composto é propício a rupturas na leitura linear da transmissão de uma matéria técnica. Ao final do Livro 1, o poema revela um mundo caótico, de guerras civis e assassinatos; o Livro 2 paradoxalmente provoca uma notável mudança de espírito: o mundo caótico dá lugar à alegria proporcionada por Baco e às colheitas fartas. Esse tratamento paradoxal parece provocar distensões nessa matéria e parece preparar o espaço para que Virgílio reflita sobre a Roma de seu tempo, do ponto de vista político e filosófico. A expressividade da linguagem poética é mais um fator que incide sobre as ambiguidades do poema, criando a imagem de que o campo dramatiza a existência humana.
Pengaruh Fear of Failure dan Motivasi Berprestasi terhadap Prokrastinasi Akademik Mahasiswa yang Mengerjakan Skripsi
Authors: Parastiara Akza Rajuwana , Yoenanto Nono Hery
Published: September 2022

Tujuan dari penelitian ini adalah untuk mengetahui pengaruh fear of failure dan motivasi berprestasi terhadap prokrastinasi akademik mahasiswa yang sedang mengerjakan skripsi atau tugas akhir. Partisipan penelitian ini merupakan mahasiswa program sarjana dari berbagai perguruan tinggi di Indonesia dengan jumlah 101 partisipan. Pengumpulan data menggunakan metode survei dan alat ukur yang digunakan adalah Performance Failure Appraisal Inventory (PFAI) (27 aitem; α=0,900), Academic Motivation Scale (16 item; α=0,794), Skala Prokrastinasi Akademik (14 item; α=0,734) yang semuanya telah dimodifikasi. Hasil penelitian ini menunjukkan nilai signifikansi 0,156 (p>0,05) dan nilai koefisien determinasi sebesar 0,037 artinya sebesar 3,7% fear of failure dan motivasi berprestasi memengaruhi prokrastinasi akademik. Kesimpulannya tidak terdapat pengaruh yang signifikan pada fear of failure dan motivasi berprestasi terhadap prokrastinasi akademik mahasiswa yang sedang mengerjakan skripsi.
Pengaruh Self-Regulated Learning terhadap Grit pada Lulusan SMA yang Menjalani Jeda Waktu
Authors: Hanifah Nur Dzakiyya  , Hendriani Wiwin
Published: September 2022

Tujuan dari penelitian adalah untuk meneliti pengaruh self-regulated learning terhadap grit pada lulusan SMA yang menjalani jeda waktu setelah mengalami kegagalan dalam seleksi masuk Perguruan Tinggi Negeri (PTN). Metode yang digunakan dalam penelitian ini adalah metode kuantitatif. Penelitian ini melibatkan 200 partisipan yang merupakan lulusan SMA pada tahun 2021 dan menjalani jeda waktu karena tidak lolos seleksi masuk PTN di tahun kelulusannya dan akan mengikuti seleksi yang sama di tahun berikutnya. Self-regulated learning diukur dengan skala self-regulated learning, sedangkan grit diukur dengan skala Grit-S yang telah diadaptasi. Hasil penelitian ini menemukan bahwa self-regulated learning memiliki pengaruh terhadap grit pada lulusan SMA yang menjalani jeda tahun setelah mengalami kegagalan dalam seleksi masuk PTN.
Peran Regulasi Emosi dalam Memoderasi Pengaruh Customer Incivility terhadap Kelelahan Emosinal Pada Frontliner Bank
Authors: Putri Farah Shabrina , Syarifah Dewi
Published: September 2022

Frontliner bank dituntut untuk selalu memberikan pelayanan terbaik bagi nasabah, namun tak jarang mereka juga mendapatkan perlakuan yang tidak menyenangkan dari nasabah atau dapat disebut sebagai customer incivility. Hal tersebut apabila berlangsung secara terus menerus dapat menyebabkan munculnya kelelahan emosional yang dirasakan oleh frontliner. Untuk meminimalisir kelelahan emosional yang dirasakan, diperlukan adanya regulasi emosi yang baik yang dimiliki oleh frontliner. Tujuan penelitian ini adalah untuk mengetahui pengaruh customer incivility terhadap kelelahan emosional, serta bagaimana regulasi emosi mampu memoderasi pengaruh dari kedua variabel tersebut. Metode yang digunakan dalam penelitian ini adalah metode penelitian kuantitatif. Dari penelitian ini diperoleh hasil, terdapat pengaruh customer incivility terhadap kelelahan emosional, serta adanya variabel regulasi emosi tidak signifikan memoderasi pengaruh customer incivility terhadap kelelahan emosional.
Hubungan Self-Control dengan Intensitas Bermain Game Online pada Remaja Akhir
Authors: Ningrum Erlin Puspita , Cahyono Rudi
Published: September 2022

Penelitian ini bertujuan untuk mengetahui hubungan self-control dengan intensitas bermain game online pada remaja akhir. Intensitas bermain game online adalah besarnya durasi dan frekuensi yang digunakan untuk bermain game online. Tingginya realitas penggunaan game online yang berlebihan pada remaja akhir selayaknya diimbangi dengan self-control pada diri untuk dapat menahan, mengatur dorongan, dan perilaku agar terhindar dari konsekuensi negatif akibat intensitas bermain game online yang berlebihan. Penelitian ini termasuk dalam penelitian kuantitatif, partisipan pada penelitian ini adalah 149 remaja akhir dengan rentang usia 18-21 tahun yang bermain game online. Uji hipotesis menunjukkan terdapat hubungan yang signifikan dan bersifat negatif pada variabel self-control dengan variabel intensitas bermain game online. Artinya, semakin tinggi self-control maka semakin rendah intensitas bermain game online. Sebaliknya, semakin rendah self-control maka semakin tinggi intensitas bermain game online.
Hubungan antara Gratitude dengan Kesejahteraan Psikologis Remaja yang Tinggal di Panti Asuhan
Authors: Hayuningputri Ersa Pawitrasari , Arbi Dian Kartika Amelia
Published: September 2022

Penelitian ini bertujuan mengetahui adanya hubungan antara gratitude dengan kesejahteraan psikologis remaja yang tinggal di panti asuhan. Partisipan pada penelitian ini terdiri dari 100 remaja yang menghuni panti asuhan di Kota Mojokerto, Kabupaten Mojokerto, dan Kota Surabaya. Penelitian menggunakan metode survei. Alat ukur yang digunakan adalah Gratitude Resentment and Apprecitation Test (GRAT) versi short form dan Ryff’s Psychological Well-being Scale yang telah diadaptasi dalam bahasa Indonesia. Analisis data menggunakan uji korelasi Pearson’s product moment dan Spearman’s rank. Hasil analisis menunjukkan bahwa gratitude berkorelasi signifikan dan positif dengan pertumbuhan pribadi (r(100)=0.246, p=0.014), hubungan positif dengan orang lain (r(100)=0.259, p=0.009), tujuan hidup (r(100)=0.205, p=0.041), dan penerimaan diri (r(100)=0.218, p=0.029). Gratitude ditemukan tidak berkorelasi dengan dimensi otonomi dan penguasaan lingkungan dari kesejahteraan psikologis.
Perbedaan Employability Mahasiswa Magang Merdeka dengan Program Magang Lainnya
Authors: Putri Bintang Eka , Wicaksono Dimas Aryo
Published: September 2022

Penelitian ini bertujuan menguji perbedaan mahasiswa yang mengikuti program Magang Merdeka dan magang reguler pada aspek-aspek employability berdasarkan kerangka teori Dacre Pool, Qualter, & Sewell. Analisis uji beda (t-test) dilakukan terhadap kedua kelompok partisipan. Hasil penelitian menunjukkan perbedaan skor employability di antara kedua kelompok partisipan hanya ditemui pada aspek work & life experience (t(240)=2,29; p=0,018; Cohen’s d=0,3; 95% CI [0,128; 1,376]). Sementara, pada keempat aspek lainnya tidak ditemukan bukti perbedaan yang signifikan di antara kedua kelompok. Temuan ini penting untuk ditindaklanjuti dalam perumusan kurikulum program magang berikutnya.
Emosia: Media Edukasi Emosi pada Anak dengan Autism Spectrum Disorder
Authors: Putro Wahyu Cahyono , Widyatamaka Arya , Sudirman Muchlisah Audina , Putri Nidya Almira Xavier Herda , Putra Yoga Santoso , Paramita Pramesti Pradna
Published: September 2022

Penelitian ini bertujuan untuk mengukur keefektifan penggunaan aplikasi Emosia sebagai media pengenalan emosi dasar pada anak-anak Indonesia dengan kondisi Autism Spectrum Disorder (ASD), sekaligus mengetahui nilai guna aplikasi bagi psikolog, terapis, serta orangtua. Emosia adalah aplikasi smartphone-mobile yang diciptakan dengan tujuan untuk menciptakan pembelajaran mengenal emosi dasar bagi anak Indonesia dengan Autism Spectrum Disorder (ASD) yang memengaruhi lebih dari 1:54 anak di Indonesia. Aplikasi Emosia diciptakan dengan metode research & development yang terdiri dari planning, production, dan evaluation. Proses evaluasi dilakukan dengan bantuan 5 pihak ahli sebagai bentuk expert judgement dengan alat skala Likert yang memiliki rentang 1-5. Hasilnya, Emosia mencapai nilai 71,67% di skala Likert, yang menandakan bahwa aplikasi ini memiliki kualitas media pembelajaran yang baik. Beberapa evaluasi seperti penggunaan model yang mungkin dapat membuat distraksi pada user dan pentingnya bimbingan orangtua atau pendamping juga diberikan sebagai saran pengembangan aplikasi.
Risk Factors of Urinary Tract Infections Caused by Extended-Spectrum Β-Lactamase-Producing Escherichia Coli in Inpatients at a Tertiary Hospital In Surabaya, Indonesia
Authors: Wuwuti Ishak Samuel , Kuntaman  , Wasito Eddy Bagus
Published: September 2022

Highlights:

ESBL frequency in women was higher than in men.
Catheter use in patients with urinary tract infections and recurrent urinary tract infections has four times the risk of ESBL caused by Escherichia coli bacteria
ESBL-producing E.coli bacteria are resistant to amoxicillin-clavulanic, ceftazidime, aztreonam, and ceftriaxone.

Abstract:
The incidence of urinary tract infections (UTIs) caused by extended-spectrum beta-lactamase (ESBL) producing Escherichia coli (E. coli) bacteria has become a global problem and has increased in recent years. The purpose of this study was to analyze the risk factors for the incidence of UTI in inpatients at Dr. Soetomo General Academic Hospital Surabaya. This research was an analytic descriptive study. Specimens were sent to the Clinical Microbiology Laboratory using sterile containers and processed according to standard laboratory procedures. It resulted in ESBL-producing E. coli that were used as a case group and non ESBL-producing E. coli as a control group. The identification and testing of antibiotic susceptibility were carried out using the BD Phoenix™ Automated Microbiology System. Ninety-four bacterial isolates were collected, consisting of 54 (57.4%) ESBL-producing E. coli bacteria and 40 (42.6%) non ESBL-producing E. coli bacteria. Recurrent UTIs (OR = 4.31; ρ =0.002; 95% CI = 1.68-11.04) and catheter use (ρ = 0.049; OR = 4.250; 95% CI = 1.050-17.210) were used as independent risk factors caused by ESBL-producing E. coli bacteria. Recurrent UTIs and catheter use were dependent risk factors caused by ESBL-producing E. coli bacteria.
Distal median and radial nerve branch transfer techniques for upper extremity reanimation
Authors: Bryan Jaimie , Nichols D. Spencer , Polansky Caroline , Oberhofer Barker Haley , Cox Elizabeth , Sullivan Brianne , Chim Harvey
Published: September 2022

Nerve transfers for peripheral nerve injuries have become increasingly popular over the past two decades. While techniques for ulnar nerve repair have been well-documented, more recent techniques for median and radial nerve branch reinnervation are still being explored. This review describes the outcomes of common and emerging techniques for reinnervation of the distal branches of the median and radial nerves.
Ten Simple Rules for Using Public Biological Data for Your Research
Authors: Oza Vishal , Whitlock Jordan , Wilk Elizabeth , Uno-Antonison Angelina , Wilk Brandon , Gajapathy Manavalan , Howton Timothy , Trull Austyn , Ianov Lara , Worthey Elizabeth , Lasseigne Brittany
Published: September 2022

With an increasing amount of "omics" data available publicly, there is a need for a guide on how to successfully download and use this data. The 10 simple rules for using public data are: 1) use public data in your research, 2) evaluate data for your use case, 3) check data reuse requirements and embargoes, 4) be aware of ethics for data reuse, 5) plan for data storage and compute requirements, 6) know what you are downloading, 7) download programmatically and verify integrity, 8) properly cite data, 9) make data FAIR and share, and 10) make pipelines and code FAIR and share. These rules are intended as a guide for researchers wanting to make use of available data and to increase data reuse and reproducibility.
Self-Medication for the Treatment of Abdominal Cramps and Pain – a Real-Life Comparison of Three Frequently Used Preparations
Authors: Storr Martin , Weigmann Harald , Landes Sabine , Michel Martin C.
Published: September 2022

Functional gastro-intestinal disorders (FGID) including irritable bowel syndrome (IBS) are frequently handled by self-management with over the counter (OTC) products such as hyoscine butylbromide (HBB), alone or in combination with paracetamol, and natural products such as peppermint oil. To obtain real-world information, we have performed an anonymous pharmacy-based patient survey among 1686 users of HBB, HBB + paracetamol and peppermint oil. Based on the distinct but overlapping indications for the three OTC products, multiple logistic regression was applied to compare them in users reporting gastrointestinal cramps and pain, bloating, flatulence, or IBS as cardinal symptom. All three treatments reduced symptoms and associated impairments of work/daily chores, leisure activities, and sleep by approximately 50%. Based on the four cardinal symptoms and the four dependent continuous variables of interest (change of intensity of symptoms and of the three impairment domains) a total of 16 logistic regression models were applied. HBB, HBB + paracetamol, and peppermint oil had similar reported overall effectiveness in those models. Gender, age, baseline symptom severity and impairment in one of three domains had small and inconsistent effects on perceived treatment success. We provide evidence that HBB, HBB + paracetamol, and peppermint oil have comparable effectiveness in their approved indications under real-world conditions in an OTC setting.
TEGDMA-Functionalized Dicalcium Phosphate Dihydrate Resin-Based Composites Prevent Secondary Caries in An In-Vitro Biofilm Model
Authors: Ionescu Andrei Cristian , Hahnel Sebastian , Chiari Marina D.S. , König Andreas , Delvecchio Paolo , Braga Roberto Ruggiero , Zambelli Vanessa , Brambilla Eugenio
Published: September 2022

This study evaluated the efficacy of experimental TEGDMA-functionalized dicalcium phosphate dihydrate (T-DCPD) filler-based resin-based composites (RBC) in preventing caries lesions around the restoration margins (secondary caries”, SC). Standardized Class-II cavities were made in sound molars having the cervical margin in dentin. Cavities were filled with a commercial resin-modified glass-ionomer cement (RMGIC) or experimental RBCs containing a BisGMA-TEGDMA resin blend and one of the following inorganic fractions: 60 wt.% Ba glass (RBC-0); 40 wt.% Ba glass, 20 wt.% T-DCPD (RBC-20); 20 wt.% Ba glass, 40 wt.% T-DCPD (RBC-40). An open-system bioreactor produced S. mutans biofilm-driven SC. Specimens were scanned using micro-CT to evaluate demineralization depths. Scanning Electron Microscopy and Energy-dispersive X-ray Spectroscopy characterized the specimens’ surfaces, while antimicrobial activity, buffering effect, and ion uptake by the biofilms were also evaluated. ANOVA and Tukey’s test were applied at p<0.05. RBC-0 and RBC-20 showed SC development in dentin, while RBC-40 and RMGIC significantly reduced the lesion depth at the restoration margin (p<0.0001). Initial enamel demineralization could be observed only around RBC-0 and RBC-20 restorations. A direct antibiofilm activity could explain SC reduction by RMGIC, while a buffering effect on biofilm’s acidogenicity explained the behavior of RBC-40. Experimental RBC with CaP-releasing functionalized T-DCPD filler could prevent SC with the same efficacy as F-releasing materials.
Maternal Mortality in Africa (Part I), Regional Trends (1990-2015)
Authors: Onambele Luc , Ortega-Leon Wilfrido , Guillen-Aguinaga Sara , Forjaz Maria João , Yoseph Amanuel , Guillen-Aguinaga Laura , Alas-Brun Rosa , Arnedo-Pena Alberto , Aguinaga-Ontoso Ines , Guillen-Grima Francisco
Published: September 2022

Background: United Nations Sustainable Development Goals state that by 2030, the Global maternal mortality rate (MMR) should be lower than 70 per 100,000 live births. MMR is still one of Africa's leading causes of death among women. This research aims to study regional trends in maternal mortality in Africa. Methods: We extracted data for Maternal mortality rates per 100,000 births from the World Bank database from 1990-2015. Joinpoint regression was used to study the trends and estimate the annual percent change (APC). Results: Maternal mortality has decreased in Africa over the study period by an average APC of -2.6%. All regions showed significant downward trends, with the sharpest decreases in East Africa. Only the North African region is close to the United Nations' sustainable development goals for Maternal mortality. The remaining sub-Saharan African regions are still far from achieving the goals. Conclusions: maternal mortality has decreased in Africa, especially in East Africa. The only region closed to the United Nations target is North Africa. The remaining sub-Saharan African regions are still far from achieving the goals. These results could be used for the development of Regional Policies.
Neck Muscle Vibration Alters Upper Limb Proprioception as Demonstrated by Changes in Accuracy and Precision During an Elbow Repositioning Task
Authors: Tabbert Hailey , Ambalavanar Ushani , Murphy Bernadette
Published: September 2022

Upper limb control depends on accurate internal models of limb position relative to the head and neck, accurate sensory inputs, and accurate cortical processing. Transient alterations in neck afferent feedback induced by muscle vibration may impact upper limb proprioception. This research aimed to determine the effects of neck muscle vibration on upper limb proprioception using a novel elbow repositioning task (ERT). 26 right-handed participants aged 22.21 2.64 performed the ERT consisting of three target angles between 80-90 (T1), 90-100 (T2) and 100-110 (T3). Controls (CONT) (n=13, 6F) received 10 minutes of rest and the vibration group (VIB) (n=13, 6F) received 10 minutes of 60Hz vibration over the right sternocleidomastoid and left cervical extensor muscles. Task performance was reassessed following experimental manipulation. Significant time by group interactions occurred for T1: (F1,24 = 25.330, p < 0.001, p2 = 0.513) where CONT improved by 26.08% and VIB worsened by 134.27%, T2: (F1,24 = 16.157, p < 0.001, p2 = 0.402) where CONT improved by 20.39% and VIB worsened by 109.54%, and T3: (F1,24 = 21.923, p < 0.001, p2 = 0.447) where CONT improved by 37.11% and VIB worsened by 54.39%. Improvements in repositioning accuracy indicates improved proprioceptive ability with practice in controls. Decreased accuracy following vibration suggests that vibration altered proprioceptive inputs used to construct body schema, leading to inaccurate joint position sense and the observed changes in elbow repositioning accuracy.
High Prevalence of Prototheca Bovis Infection in Dairy Cattle with Chronic Mastitis in Ecuador
Authors: Huilca María Paula , Vasco-Julio David , Ledesma Yanua , Guerrero-Freire Salomé , Zurita Jeannette , Castillejo Pablo , Barceló-Blasco Francisco , Yanez Lisseth , Changoluisa Darwin , Echeverría Gustavo , Bastidas-Caldés Carlos , Waard Jacobus H. de
Published: September 2022

The genus Prototheca, unicellular, non-photosynthetic, yeast-like microalgae, is a pathogen of concern for the dairy industry causing bovine mastitis that currently cannot be cured and hence generates significant economic losses in milk production. In this study, for the first time in Ecuador, we identify Prototheca bovis as the etiologic agent of chronic mastitis in dairy cattle. Milk samples (n=458) of cows with chronic mastitis were cultured on Sabouraud Dextrose Agar (SDA). Microscopy and cytB gene sequencing were used to identify Prototheca, whereby Prototheca bovis was isolated from 15.1% (n=69) of the milk samples, one of the highest infection rates that can be found in the literature in a “non-outbreak” situation. No other Prototheca species were found. We were unable to isolate the alga from environmental samples. We showed that P. bovis was relatively resistant to disinfectants used to sterilize milking equipment on the cattle farms where it was isolated. We discuss how to avoid future infection and also hypothesize that the real prevalence of Prototheca infection in bovine mastitis is probably much higher than what was detected. We recommend a protocol to increase the diagnostic yield in the bacteriology laboratory.
Synergistic Interaction of A Healthy Lifestyle Index and Antioxidant Genes on Breast Cancer Risk
Authors: Gomez Flores Ramos Liliana , Sánchez Zamorano Luisa María , Ángeles-Llerenas Ángelica , Torres-Mejía Gabriela
Published: September 2022

Lifestyle has been associated with breast cancer risk through different pathways, including oxidative stress. Antioxidant enzymes are endogenous defense mechanisms against oxidative stress damage, and this response might be modulated by the genetic variation in these enzyme-codifying genes. This study aimed to analyze the synergistic effect of an antioxidant Healthy Lifestyle Index (HeLiX) composed of principal components of Western dietary pattern, alcohol consumption, smoking and physical activity, and genetic polymorphisms in the first-line antioxidant response family genes SOD, GPX, and CAT on breast cancer risk. We included 176 SNPs, and only CAT rs554576 remained significant after correction for multiple comparisons. Breast cancer odds were reduced at the highest (T3) and medium (T2) tertiles of the HeLiX. When stratified by HeLiX, we observed a reduced risk of breast cancer with at least one T-allele, and the effect increased in a dose-dependent manner. Compared to the reference category (HeLiX T1 and AA genotype), women at the HeLiX T3 with AT and TT genotypes in postmenopausal women showed an OR = 0.15 (95% CI 0.07–0.32). For HeLiX T2 and AT genotype OR = 0.26 (95% CI 0.13–0.54); for TT genotype OR = 0.24 (95% CI 0.12–0.45). For premenopausal women, at the HeLiX T3 and AT genotype OR = 0.29 (95% CI 0.13–0.62); for the TT genotype OR = 0.21 (95% CI 0.08–0.51). We also observed an inverse association for HeLiX T2 and TT genotype (OR 0.39 95% CI 0.17–0.87). Our study shows a significant synergistic gene-environment interaction on an additive scale, contributing to understanding pathways involved in breast cancer etiology and prevention.
An Exploration of Employer Participation in Internships and Other Work-Based Learning Experiences
Authors: Johnson Kawana Williams
Published: September 2022

Research shows that employers play a key role in work-based learning (WBL) programs such as internships but are seldom involved in conversations around the topic (Greenfield & Stevens, 2018). While the benefits of work-based learning are well documented, employers are often unaware of the benefits they would receive from participating in an effort to strategically link education and workforce preparation (Greenfield & Stevens, 2018). This study qualitatively examined the experiences of employers that provide work-based learning opportunities, primarily internships, for postsecondary students. Findings illuminated the importance of developing and maintaining strong community partnerships and establishing recruitment pipelines. The results also indicated that lack of information impedes growth, virtual experiences are essential, and financial constraints impact participation.
REPRESENTATION OF MINORITIES IN URDU PRESS IN PAKISTAN
Authors: khalid zara
Published: September 2022

The fundamental goal of this research article was to investigate the coverage of minority groups in Urdu press of Pakistan. For this purpose, 1 Pakistani newspaper daily Jang Karachi and 1 weekly magazine Akhbar-e-Jehan was selected. 198 newspapers and 48 magazines were selected through systematic sampling from June 2020 to June 2021. It was found that 100 news stories were published in daily Jung while 10 news stories about minorities were published in Akhbar-e-Jehan, which means during the last year from June 2020 to June 2021, minorities have been represented only 0.404% in Daily Jang Newspaper and only 0.771% in weekly Akhbar-e-Jehan. For this purpose, a content analysis of selected news items were undertaken in which it was also found that 40% positive news and 60% negative news were published related to minorities of Pakistan in Daily Jung while 90% negative and 10 positive news were published in weekly magazine Akhbar-e-Jehan during June 2020 to June 2021. The research also revealed that the major problems which minorities are facing that is blasphemy allegations forced conversions etc. were not highlighted as it should be
A rare case of Cushing’s disease developing years after Craniopharygioma
Authors: Urhan Emre , Kara Canan Sehit , Okcesiz Izzet , Ozturk Figen , Kurtsoy Ali , Bayram Fahri
Published: September 2022

Craniopharyngioma (CP) is a rare benign tumor originates from sellar/suprasellar region. It accounts for 1.2–4.6% of all intracranial tumors. Although it is known as childhood disease, it can be diagnosed at all ages. Despite its long-term survival rate is high, the risk of recurrence is also high. There are some treatment options such as radical surgery, radiotherapy and intracystic treatment, but an individualized treatment approach is required. We present a case of craniopharyngioma relapsed as Cushing’s disease (CD). 18-year-old female patient was admitted to hospital 10 years ago with complaints of menstrual irregularities, headaches, nausea, vomiting and visual impairment. Laboratory examination revealed panhypopituitarism. Pituitary magnetic resonance imaging (MRI) showed a 22x13x14 mm mass lesion with solid and cystic components. Transsphenoidal (TS) pituitary surgery was performed. Pathological examination concluded as CP. The patient did not follow up regularly after surgery. Post-operative second year pituitary MRI revealed an empty sella appearance. The patient was admitted with complaints of headache, weight gain and absence of menstrual cycles 8 years after the surgery. Post-operative 8th year pituitary MRI demonstrated a 28x16x18 mm mass lesion that completely filled the sellar cavity and extended to the suprasellar region and both cavernous sinuses. TS pituitary surgery was performed for the second time. Histopathological and immunohistochemical examination showed ACTH-secreting pituitary adenoma. To our knowledge, this is the first case of Cushing's disease developing after years from operation of craniopharyngioma reported in the literature. Finally, long-term follow-up is very important for post-surgical recurrence in patients with sellar region tumors.
Proper rest during the long-time reading on smartphones may be a convenient and effective pevention strategy for DED and asthenopia
Authors: Wang Ning , Min Jinjin , Fan Xiaojing , Yuan Kelan , Wu Yaying , Wang Xin , Mou Yujie , Wang Chunyang , Jin Xiuming
Published: September 2022

Purpose
The study aims to evaluate the effect of proper rest during the long-time smartphone reading on DED and asthenopia.
Methods
Healthy participants over the age of 18 were randomly allocated to three groups and each individual accepted 2h smartphone reading task. After 1h each group took different rest methods: no rest (group A), eye-closed rest for 10mins (group B), eye-closed joint eye drops rest for 10mins (group C). Before and after the reading task, DED and asthenopia were evaluated by the Ocular Surface Disease Index (OSDI), critical flicker frequency (CFF), non-invasive break-up time (NIBUT), fluorescein break-up time (FBUT), corneal fluorescein staining (CFS), and the Schirmer I test (SIT).
Results
90 qualified volunteers were recruited, including 29 males and 61 females, aged 22–30 years. After the reading task, all indexes in group A showed the degree of DED and asthenopia were worse than that before reading. Most indexes of DED and asthenopia had no obvious change in group B and group C, especially the CFS results improved (P > 0.05) in group C.
Conclusions
Our results suggested that taking proper rest during the long-time reading on smartphones may be a convenient and effective prevention strategy for DED and asthenopia.
Precision Medicine and Machine Learning to predict critical disease and death due to Coronavirus Disease 2019 (COVID-19)
Authors: Junior Walton Luiz del Tedesco , Danelli Tiago , Tano Zuleica Naomi , Cassela Pedro Luis Candido Souza , Trigo Guilherme Lerner , Cardoso Kauê Morais , Loni Livia Padovani , Ahrens Tainah Mendes , Espinosa Beatriz Rabello , de Almeida Elaine Regina , Lozovoy Marcell Alysson Batisti , Reiche Edna Maria , Maes Michael , Simão Colado
Published: September 2022

The early stage of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, may be accompanied by high activity of the nucleotide-binding domain, leucine-rich repeat and pyrin domain-containing protein 3 (NLRP3) inflammasome and a cytokine storm. The aim of the study was to construct Machine Learning (ML) models that predict critical disease, severity of Coronavirus Disease 2019 (COVID-19), and death due to COVID-19. This cross-sectional study recruited 528 COVID-19 patients divided into those with critical (n = 308) and non-critical (n = 220) disease. The ML models included baseline imaging, demographic, and inflammatory data as well as NLRP3 (rs10754558 and rs10157379) and IL18 (rs360717 and rs187238) genetic variants. Partial least squares analysis showed that 49.5% of the variance in severity of critical COVID-19 can be explained by SpO2 and the sickness symptom complex (SSC) (inversely associated), chest computed tomography alterations (CCTA), inflammatory biomarkers, severe acute respiratory syndrome (SARS), body mass index (BMI), type 2 diabetes mellitus (T2DM), and age (all 7 positively associated). In this model, the four NLRP3/IL18 gene variants showed significant indirect effects on critical COVID-19 which were completely mediated by inflammatory biomarkers, SARS, and SSC. Neural network models, which entered SSC, SARS, CCTA, SpO2, age, T2DM, hypertension, inflammatory biomarkers and gene variants, yielded a significant prediction of critical disease and death due to COVID-19 with an area under the receiving operating characteristic curve of 0.930 and 0.927, respectively. Our ML methods increase the accuracy of predicting the severity, critical illness, and mortality caused by COVID-19 and show that the genetic variants contribute to the predictive power of the ML models.
Benign pneumoperitoneum associated with a ureteral stone: a case report
Authors: Vargas Mario Rozo , Rubiano S. Nicolás , Saenz Maria Paula
Published: September 2022

PurposePneumoperitoneum is mainly associated with perforated abdominal viscus. However, some cases do not involve perforation and do not require surgical intervention, and thus, benign pneumoperitoneum is diagnosed. In rare cases, urological causes can be related to benign pneumoperitoneum. We present a case of benign pneumoperitoneum related with urolithiasis, an association never reported before.Presentation of caseWe report the case of a 53-year-old male who presented to the emergency department due to a renal colic. Laboratory tests were not suggestive of any infectious or inflammatory processes. Imaging studies revealed a ureteral stone and an incidental finding of pneumoperitoneum not related to viscus perforation. A surgical procedure was indicated for urolithiasis, and several causes of pneumoperitoneum were ruled out. Follow-up studies showed spontaneous pneumoperitoneum regression, and the patient remained asymptomatic. However, the precise cause of the pneumoperitoneum remains unclear.DiscussionTo our knowledge, this is the first case reported of benign pneumoperitoneum associated with urolithiasis. It is important to highlight that this condition could be managed without surgical intervention after general surgery consultation is obtained. An extensive history and physical examination support the dismissal of bowel perforation as the etiology of pneumoperitoneum.ConclusionsBenign pneumoperitoneum remains a diagnostic and therapeutic challenge that, in all cases, requires general surgery consultation to determine the likelihood of bowel perforation and establish an appropriate management for each patient, especially in the decision making of the pertinence of surgical intervention.
Microbial life in ancient permafrost along a salinity gradient illuminated by metagenomics
Authors: Wu Xiaofen , Almatari Abraham L. , Williams Daniel E. , Pfiffner Susan M. , Rivkina Elizaveta M. , Lloyd Karen G. , Vishnivetskaya Tatiana A.
Published: September 2022

This study describes the composition and potential metabolic adaptation of microbial communities in northeastern Siberia, a repository of the oldest permafrost in the Northern Hemisphere. Samples of contrasting depth (1.75 to 25.1 m below surface) and age (from ~ 10 kyr to 1.1 Myr) were collected from freshwater permafrost (FP) of borehole AL1_15 on the Alazeya River, and freshwater coastal permafrost (FCP) overlying marine permafrost (MP) of borehole CH1_17 on the East Siberian Sea coast. Using 16S rRNA gene sequencing, we showed that the biodiversity decreased dramatically with permafrost age and separated the samples into three groups: FP and FCP together (10–100 kyr old), FP (> 900 kyr old), and MP (105–120 kyr old). Younger FP/FCP deposits were distinguished by the presence of Acidobacteriota, Bacteroidota, Chloroflexota_A, and Gemmatimonadota, older FP deposits had a higher proportion of Gammaproteobacteria, and older MP deposits had much more uncultured groups within Asgardarchaeota, Crenarchaeota, Chloroflexota, Patescibacteria, and unassigned archaea. The 60 recovered metagenome-assembled genomes (MAGs) and un-binned metagenomic assemblies suggested that despite the large taxonomic differences between samples, they all had a wide range of taxa capable of fermentation coupled to nitrate utilization, with the exception of sulfur reduction present only in old MP deposits.
Generalized multipartite entropic uncertainty relations: theory and experiment
Authors: Wang Zhao-An , Xie Bo-Fu , Ming Fei , Wang Yi-Tao , Wang Dong , Meng Yu , Liu Zheng-Hao , Tang Jian-Shun , Ye Liu , Li Chuan-Feng , Guo Guangcan , Kais Sabre
Published: September 2022

Entropic uncertainty relation (EUR) plays a vital role in quantum information theories by demonstrating the intrinsic uncertainty of nature from the information-theoretic perspective. A tighter lower bound for uncertainty relations facilitates more accurate predictions of measurement outcomes and more robust quantum information processing. However, meaningful EURs in multipartite scenarios are yet to be identified. In this study, we derived a generalized EUR (GEUR) for the measurement of multiple observables in arbitrary many-body systems. The corresponding GEUR bound is shown to be tighter than Renes--Boileau \textit{et al.}'s bound when applied in a tripartite scenario. We experimentally tested the GEUR with a four-photon entangled state in an optical platform. We demonstrated that GEUR provides a tighter lower bound of the quantum-secret-key rate, which can readily accelerate practical quantum key distribution protocols. By providing a close peek at the nature of uncertainty, our results may find broad applications in the security analysis of quantum cryptography.
A method for automatic Arabic text summarization combining Noun Extraction and Fuzzy Logic
Authors: Qassem Lamees M. Al , Wang Di , Barada Hasan , Al-Rubaie Ahmad , Almoosa Nawaf I.
Published: September 2022

Text summarization has been a field of intensive research over the last 50 years, especially for commonly used and relatively simple-grammar languages such as English. Moreover, the unprecedented growth in the amount of online information available to users and businesses, including news articles and social media, has made it difficult and time consuming for users to identify and consume sought after content. Hence, an automatic text summarization system to generate accurate and relevant summaries from the huge amount of information available is essential nowadays. The Arabic language is no exception in terms of the upsurge in available information, especially online, however, techniques and methodologies for automatic Arabic text summarization are still immature due to the inherent complexity of the Arabic language in terms of both structure and morphology. The work presented in this paper attempts to improve the performance of Arabic text summarization. We propose a novel Arabic text summarization approach based on a noun extraction method and Fuzzy Logic (FL). The proposed system is one of the first Arabic text summarizers to use FLFL to improve the summarization accuracy. The proposed summarization system is evaluated on EASC corpus and compared against popular state of the art Arabic text summarization systems. The results indicate that our proposed FLFL based approach with noun extraction outperforms existing prior art systems.