bluuebunny/crossref_metadata_2025 huggingface dataset:
DISEÑO DE UN MODELO DE INNOVACIÓN SOCIAL TRANSFORMATIVA PARA LAS AGROINDUSTRIAS: CASO SOLANUM TUBEROSUM EN ZIPAQUIRÁ CUNDINAMARCA
Authors: Campos Naranjo Jose Ignacio , Castañeda Cristancho Karen Ximena , Urbina Aguilar Jose David
Published: November 2024

El municipio de Zipaquirá se caracteriza por ser un territorio de gran importancia económica en el departamento de Cundinamarca, debido a la riqueza de sus recursos naturales, que procuran un entorno prospero para la producción agrícola. En el caso particular, el municipio es catalogado por ser uno de los mayores productores de papa (Solanum tuberosum) en sus diferentes variedades.  Este panorama ha dado lugar, problemas en el ámbito social, económico y ambiental.  Dado a que la población presenta desigualdad social, generada por la comercialización de sus productos por debajo de los precios reales.
Considerando su extenso y diversificado sistema de producción agrícola, en comparación con otros municipios de la región, se ha observado un aumento significado en la comercialización y el uso de productos agroquímicos. Esta tendencia ha generado un impacto negativo tanto en la economía de los pequeños productores como en los recursos ambientales del municipio, incluyendo el agua, los suelos, fauna y flora locales. Teniendo en cuenta la problemática, se llevaron a cabo análisis con el objetivo de proponer soluciones al sector papicultor, en colaboración de la innovación social transformativa y la perspectiva multinivel (MLP).
La investigación comenzó con la elaboración del instrumento de caracterización que comprende las variables del modelo con impacto directo en el sector. En colaboración con la Secretaría de Desarrollo Rural y Ambiente de Zipaquirá, se llevaron a cabo encuestas a los papicultores. Estas respuestas, de naturaleza cualitativa, fueron analizadas con la ayuda del software NVIVO. Los resultados de este estudio resaltan la sólida interrelación entre las tres variables fundamentales del proyecto de innovación social transformativa: paisaje, nicho y régimen. Este enfoque integral ofrece una comprensión completa y profunda del sector.
PRONÓSTICO DE TASAS USD/COP Y EUR/COP MEDIANTE DIFERENTES TÉCNICAS
Authors: Zapata Rodríguez Linda Yurley , Medina Jiménez Manuela , Conto López Romario Ademir
Published: November 2024

En este artículo se realiza una aplicación de modelos de pronóstico para las tasas de cambio dólar y euro con relación al peso colombiano, con el objetivo de determinar cuál es el mejor método para predecir estas divisas. Son aplicados los modelos ARIMA, Suavizamiento Exponencial de Holt y Redes Neuronales, cuya eficiencia fue estudiada mediante el uso del error absoluto medio (MAE) y el error porcentual absoluto medio (MAPE). Se obtuvo que, tanto en el ajuste al histórico como el cálculo de predicciones futuras para ambas divisas, el mejor modelo fue la Red Neuronal Artificial ajustada, seguido por el suavizamiento Holt implementado y por último el modelo ARIMA (0,1,2) ajustado.
DESARROLLO DE UN PLAN DE MARKETING PARA UNA EMPRESA DE ALOJAMIENTO RURAL
Authors: Ayala Fuentes Orlando , Restrepo Torres Simón , Fuentes Rojas Ever Ángel
Published: November 2024

El sector turístico se ha consolidado como emergente para la economía colombiana, especialmente el ecoturismo, el cual se convierte en una de las principales tendencias gracias a la alta concentración de la población en las zonas urbanas. Es por esta razón que aquellas poblaciones pequeñas que poseen un atractivo inherente y se encuentran en las cercanías de las grandes ciudades demuestran un gran potencial para el desarrollo de empresas de alojamiento y demás servicios turísticos. El presente artículo expone los resultados de un plan de marketing para la empresa Eco-Cabañas Altozano SAS, ubicada en el Municipio de Nimaima. La investigación se construye a partir de fuentes primarias, a las cuales se tuvo acceso mediante la gerente, y a partir de fuentes secundarias recopiladas por los investigadores. Los resultados permiten evidenciar que, a pesar de estar en un entorno con alta competitividad, el proyecto cuenta con un potencial de crecimiento si aprovecha la creciente demanda. Con este fin se formulan estrategias basadas en aumentar la visibilidad de la oferta actual, se determina el posicionamiento de la compañía, se establece el marketing mix y se crean las políticas de precios, descuentos, ofertas y promociones. Finalmente, se hacen las estimaciones económicas correspondientes, las cuales proyectan un crecimiento año contra año.
A Systematic Literature Review of Teaching Employability: A focus on soft skills
Authors: Otermans Pauldy , Nagada Urmi , Aditya Dev , Pereira Monica
Published: November 2024

Employability skills are important to be successful in any job in the job market. Colleges and universities should focus on teaching these skills to students to prepare them for the world of work. There are an abundance of studies that have highlighted the skills gap. This paper aims to bring together the literature to review how these skills are best taught to students. Five Databases - SocIndex, Education Resources Information Centre, British Education Index, Education Abstracts, and Education Research Complete - were thoroughly reviewed. Papers on teaching, training or learning of soft, transferable, employability, life, leadership or management skills from the years 2015-2023 were gathered. Results showed that certain classroom activities and games can be used to teach certain skills to the students. Part-time or full-time employment, internships and volunteer work also lead to development of skills such as leadership, communication, and social skills. Higher educational institutions can hence employ the pedagogical methods and approaches mentioned in these studies to teach employability skills to students.
Mechanism of sweetening effect of 2-methylbutyric acid and other 9 acids from sweet orange investigated by sensory evaluation, electronic tongue, and molecular simulation
Authors: Xiao ZuoBing , Shen BingJian , Niu YunWei , Zhu JianCai , Yu YaMin , She YuanBin , Zhou RuJun , Wang ZhaoGai , Zhang Jing
Published: November 2024

This study investigates the sweetening effect of ten acids from sweet orange on 5% sucrose solution. It was discovered that trans-2-hexenoic acid, 2-methylbutyric acid and 3-methylbutyric acid notably enhanced sweetness, whereas decanoic acid significantly reduced sweetness. Acetic acid, propionic acid and butyric acid sweetened slightly at low concentration, but inhibited sweetness at high concentration. Hexanoic acid, octanoic acid were also sweetened, but the comfort level was declining. Nonanoic acid did not significantly sweeten or inhibit sweetness. The results of molecular docking revealed that hydrogen bonding and hydrophobic interactions were crucial for the binding of sucrose to the sweet taste receptor T1R2/T1R3. It has also found that LYS65, ASP278, SER165, GLU302, ASP142, and SER303 were key amino acids for sweetness. A 100 ns molecular dynamic simulation indicated that the addition of propionic acid reduced the equilibrium time from 60 ns to 10 ns to improve the combination of sucrose and T1R2/T1R3. This findings pave the way for developing low-sugar orange juice beverages by leveraging aroma substances to augment sweetness.
Complete Substitution of fish meal with black soldier flies Hermetia illucens (L. 1758) larvae meal at varying incorporation rates for feeding Oreochromis niloticus raised in captivity
Authors: Vodounnou Juste Vital , Iko Romaric , Okou Godwin , Kpogue Diane , Montcho Simon Ahouansou , Micha Jean-Claude
Published: November 2024

Background
Black soldier fly larvae are exceptional ingredients, often used to replace fish meal. They can be easily cultured using waste and by-products. This study assesses the effect of black soldier fly larvae (BSFL) meal on the growth of Oreochromis niloticus raised in captivity, as well as the economic impact of replacing fish meal with BSFL meal in its diet.
Method
Black soldier fly larvae (BSFL) were produced for 15 days after egg hatching. The substrate of BSFL production was Soy bran obtained by processing soy cheese. Five different treatments were applied, with TR (imported feed); T0 (diet with 0% incorporation of black soldier fly larvae meal); T40; T50 and T60 are diets with 40%, 50% and 60% incorporation of black soldier fly larvae meal. The feeding frequency was 4 times/day. Each treatment was tested in triplicate for 28 days.
Results
The specific growth rate obtained during the experiment varied significantly (P < 0.05) with the treatments from 2.88 ± 0.09 to 4.50 ± 0.12%/day. The feed conversion rate (FCR), ranged from 2.25 ± 0.05 (T40) to 1.08 ± 0.04 (T60). The protein efficiency ratio (PER) showed a significant difference (P < 0.05) with the treatment. It ranged from 0.81 ± 0.07 (T40) to 2.34 ± 0.06 (TR). The survival rates varied from (T0) (92.66 ± 3.52) to (T50) (100.00 ± 0.00). The economic conversion ratio (ECR) presented a significant difference (P < 0.05). The best ECR was obtained with T60 (1.62 ± 0.09) and T50 (2.42 ± 0.17). Based on the parameters studied, 40%, 50%, and 60% of BSFL meals showed better performance compared to fish meal. The cost production analyses were used to evaluate the economic impact of utilizing BSFL meal instead of fish meal in O. niloticus feeding.
Conclusion
It is recommended to use 50% and 60% substitution rates for better economic profitability.
Enhanced virus infection in Nicotiana benthamiana transiently overexpressing MDP92 , encoding a tobacco MYB transcription factor
Authors: Yoshikawa Munehisa , Shirai Rikako , Suzuki Taiga , Matsushita Yasuhiko , SASAKI Nobumitsu
Published: November 2024

Transcription factors including MYB proteins are involved in plant resistance to viruses. However, the information on the role and function of MYB proteins during plant virus infection is limited. In this study, we found the trend that the expression of a tobacco MYB gene (MDP92) is temporarily be downregulated in tobacco cultivars with and without the virus resistance gene N during tobacco mosaic virus infection. To test a possible involvement of MDP92 in the regulation of virus infection, we investigated the effect of the transient overexpression of the MDP92 coding sequence alone or in combination with the N genomic sequence on infection with GFP-encoding tomato mosaic virus in Nicotiana benthamiana. Overexpression of MDP92 promoted virus intercellular movement in leaves in the presence of N and enhanced virus accumulation in leaves and protoplasts in the absence of N. Gene expression analysis of four selected resistance-related genes (NbPR1a, NbPR4, NbHin1, and NbHsr203j) showed that compared to control leaves, only NbHsr203j expression was significantly downregulated in MDP92-overexpressing leaves with N, and the expression of NbPR4 and NbHin1 was significantly upregulated in MDP92-overexpressing leaves without N. In contrast, NbPR1a expression was not affected by MDP92 overexpression. Transient overexpression of MDP92 without N also resulted in enhanced accumulation of potato virus X with upregulation of NbPR4 and NbHin1 expression during early virus infection. Based on these results, we discuss the role of the transcription factor MDP92 during virus infection.
Exploring the vicious cycle of climatic challenges with the soil system in 5 continents of the world due to the low cognitive of consuming historical products of agricultural revolutions
Authors: Sadaty Seyyed Akbar , Friedrich Theodor
Published: November 2024

Background and Objectives The process of urban and rural population increase, and the impact of household competition in providing the basic needs of life, has caused the consumption of various resources to grow rapidly and unevenly in the 5 continents of the world. In such a competitive environment, the world's agricultural soil systems, by receiving the products of agricultural revolutions, have made the climate out of the global order. So, the purpose of this strategic research is to discover the missing links in the low cognitive of the Decision-making managers, in the biochemical and physicochemical historical process of the soil in the use of the products of the agricultural revolutions. Materials and
Methods In this way, the conventional structure of culture and different environmental civilizations of the 5 continents of the world with the system of agricultural soils and climate has led to the use of the model (SMM) for the purposes of our research. For the meantime, two related and interconnected statistical methods have been used to achieve the desired global results. Also, in this section, the main components of process evaluation (10 main components of soil and 730 manuscripts of scientists from the world's most prestigious journals) has been used. For the process analysis of this research, strategic thinking, Excel and SPSS have been used.
Results and Discussion According to the trend of anthropogenic effect on 10 components of the world's agricultural soils and the revelation of two effectiveness (CPEP=47.8% and CPAR=54.2%), global climate changes have appeared. In the meantime, the low cognitive effect of the components involved in the 5 continents of the world has been able to attribute 58.5% of climate changes to agricultural soils.
Conclusion and Suggestions The results of this strategic multidisciplinary research, which was associated with the identification of driving factors (strengths and opportunities) and inhibiting factors (weaknesses and threats) in the world, showed that climate change is dependent on anthropogenesis. At the end of this exhausting effort, 10 strategic suggestions along with the pragmatism paradigm were communicated to the world.
Influences of freezing and thermal cyclic loading on physical and mechanical properties of marble
Authors: Faramarzi Lohrasb , Dehghani Bijan , Azhari Amin
Published: November 2024

In this study, marble specimens were used to investigate the effects of freezing and thermal cyclic loading on physical and mechanical properties. For this purpose, four types of loading were considered, including freezing-cooling (F-C), heating-cooling (H-C), freezing-cooling-heating (F-C-H) and heating-cooling-freezing (H-C-F). The changes observed in physical and mechanical properties of the marble were analyzed in temperature extend shifting from − 30°C to 160°C. To achieve this goal, two marble blocks with a dimension of 30×30×30 cm3 were selected. Then, compressive and shear wave velocities, uniaxial compressive strength (UCS), Young's modulus (E) and Brazilian tensile strength (BTS) were measured and compared in different loading conditions. Results showed that the number of freezing-cooling cycles influenced the mechanical properties of the marble. With an increase in the loading cycles, both compressional and shear wave velocities of the marble decreased. The highest reduction in tensile strength was observed in heating-cooling cycles. That is to say, the thermal loading of rock specimens caused weakening, thereby increasing the micro-crack density in the marble specimens by means of thermally shocks. It was observed that the increase in the number of loading cycles, brings about a huge decline in the marble dynamic modulus. The damage index (D) is introduced to reflect the variation of the mechanical properties and ultrasonic wave velocities of the samples before and after the thermal cyclic loading. In all freezing and thermal cyclic loading conditions, the main and predominant failure mechanism was shear failure.
Bifuruzan Skeleton: Developing New High-Energy and High- Density Energetic Materials
Authors: Yang Zhanglei , Li Junyan , Tang Jincui , Luo Wenxiu , Liang Ying , Zhao Tingxing , Zhang Jianguo , Li Hongbo , Wu Jinting
Published: November 2024

High-energy density materials (HEDMs) are integral to modern society and are in high demand. Consequently, the design and synthesis of energetic material molecules have garnered significant research interest. This study focuses on the furazan ring system as a core for developing superior HEDMs. We employed density functional theory (DFT) to assess the properties of 27 novel energetic compounds, including their geometries, densities, enthalpies of formation, detonation velocities, detonation pressures, and molecular orbital energies (HOMO-LUMO). The computation of detonation velocity and detonation pressure was based on theoretical density and enthalpy of formation. The findings revealed that incorporating energetic groups into the furazan framework, linked by sec-ammonia bridge (-NH-), enhances both the detonation performance and oxygen content of the materials. This enhancement guides the future synthetic endeavors aimed at creating advanced HEDMs.
Co-GWAS unveils the genetic architecture of inter-individual epistasis affecting biomass and disease severity in wheat binary mixtures
Authors: Mathieu Laura , Montazeaud Germain , Delmond Mathilde , Brousse Andy , Fréville Hélène , Méteignier Louis-Valentin , David Jacques , Morel Jean-Benoît , Ballini Elsa
Published: November 2024

Identifying the genetic determinants underlying plant-plant interactions is key for understanding plant community dynamics, both in natural and agronomical systems. This report unveils the complex genetic architecture of plant-plant interaction effects on aerial biomass and septoria tritici blotch severity in varietal mixtures of wheat, using co-genome-wide association study. Fifty-four significant allelic interactions between distinct loci were identified, with half involving hub loci. Some inter-individual epistasis might be related to the shade-avoidance syndrome. Our results underscore the critical role of allelic interactions between inter-individual loci in shaping plant phenotypes and community dynamics, offering new perspectives to optimize varietal mixtures.
Eucommia folium can be prepared into tea with the ability to prevent and treat hyperuricemia
Authors: Hao Qing , Liu Ying , Zhai Zikun , Wang Bo , Jiang Lin , Zhang Qiyun , Su Jiawei , Zhang Maiting , Li Jiajun , Chen Shuo , Ye Ziyun , Zheng Qiusheng , Fan Xiangcheng , Han Jichun
Published: November 2024

The aim of this study was to investigate the antihyperuricaemic (HUA) effect of Eucommia folium after preparing a tea made from its leaves (abbreviated as DZ) which has the ability to prevent and treat HUA. In this study, a mouse HUA model was established via gavage of potassium oxonate and hypoxanthine, and this HUA model was treated with DZ to investigate the therapeutic effect of DZ on HUA. This study recruited 30 HUA volunteers, who drank 10 g of DZ daily for 4 consecutive weeks. The serum HUA levels of UA volunteers were measured once per week to observe the anti-HUA efficacy of DZ at the clinical level. Animal experiments have shown that DZ has therapeutic effects on HUA. DZ effectively reduces the levels of uric acid (UA), creatinine (Cr), and urea nitrogen (BUN) in the serum of HUA mice; decreases xanthine oxidase (XOD) activity in the serum; and alleviates damage to kidney tissues and glomeruli. Metabolomic analysis revealed that DZ affects multiple metabolites, such as orotidine, orotic acid, ureidosuccinic acid, 1-methylhistidine, and other metabolites, and these metabolites are involved mainly in pyrimidine metabolism, histidine metabolism, and riboflavin metabolism. Clinical research revealed that, after DZ was consumed, the UA levels in the HUA volunteers significantly decreased. DZ can prevent and treat HUA, and is in the same class of traditional Chinese medicines used in medicine and food, with extremely low toxicity and high safety. Therefore, DZ is suitable as a functional food for the prevention and treatment of HUA.
A new tubalepid (Antiarcha, Placodermi) from the Middle Devonian of Huize, Yunnan, China
Authors: Luo Yanchao , Pan Zhaohui , Zhu Min
Published: November 2024

A new tubalepid antiarch, Tongdulepis concavus gen. et sp. nov., is described from the Middle Devonian (Qujing Formation, late Eifelian) of Huize County, Qujing, northeastern Yunnan, China. It differs from other antiarchs in the trapezoidal premedian plate, absence of postmarginal plate (except Tubalepis), spade-shaped preorbital recess, contorted infraorbital sensory line on the lateral plate, and the anterior median dorsal plate with broad anterior margin and concave posterior margin. This material confirms the absence of the postmarginal plate in Tubalepididae and adds to our understanding of the neurocranium and brachial process in the primitive bothriolepidoids. Our phylogenetic result places Tongdulepis within Tubalepididae, at the plesiomorphic position of the Tenizolepis-Dianolepis-Bothriolepis lineage.
Quantification and localization of a surface crack in a thick aluminum plate using Rayleigh waves electromagnetic acoustic transducers
Authors: Ahmad Mubarak
Published: November 2024

Surface cracks are measured and analyzed in different materials, structures, or some of its components to determine its severity, rate of growth, and potential impact on integrity. In different research materials, structural health monitoring, and civil engineering like areas, the evaluation of cracks is very critical. To accurately quantify the depth of surface crack using conventional nondestructive testing techniques it is very challenging. The current work includes the development of a novel Velocity-Time (V-T) graph approach that uses Rayleigh wave to quantitatively evaluate the depth and localization of surface-breaking cracks. Structure of aluminum alloy with slots of various depths was studied both experimentally and numerically. To investigate the interaction between surface breaking cracks of varying depths and Rayleigh surface waves generated by a point Rayleigh wave EMAT, a two-dimensional (2D) numerical model based on the finite element approach was developed. Rayleigh waves are utilized to quantify the depth of surface cracks in a metallic structure based on proposed approach. This method makes use of Rayleigh waves that are directly related between a fixed transmitter and a uniformly moveable receiver. A pair of similar electromagnetic acoustic transducers (EMATs) operating in a pitch-catch mode were employed to generate, propagate and receive Rayleigh waves at the surface of the structure. An analytical expression for the evaluation of crack depth has presented. The experimental results has showed that this time-of-flight method can be utilized to properly measure the depth of crack and agreed well with the numerical simulation. This study has provided a feasible idea to analyze thick plates using Rayleigh wave EMATs to quantitatively estimate the depth of surface-breaking cracks. Results have showed that this novel approach has significantly amplified the accuracy of surface crack localization and quantification (with a maximum error of 6.7%).
Unveiling prognostic value of JAK/STAT signaling pathway related genes in colorectal cancer: a study of Mendelian randomization analysis
Authors: Zhang Nan , Yue Wenli , Jiao Bihang , Cheng Duo , Wang Jingjing , Liang Fang , Wang Yingnan , Liang Xiyue , Li Kunkun , Liu Junwei , Li Yadong
Published: November 2024

Background
Colorectal cancer (CRC) ranks among the frequently occurring malignant neoplasms affecting the gastrointestinal tract. This study aimed to explore JAK-STAT signaling pathway related genes in CRC and establish a new prognostic model.
Methods
The data set used in this study is from a public database. JAK-STAT-differentially expressed genes (DEGs) were identified through differential expression analysis and weighted gene co-expression network analysis (WGCNA). Prognostic genes were selected from JAK-STAT-DEGs through Mendelian randomization (MR), univariate Cox regression, and least absolute shrinkage and selection operator (LASSO) analyses. The expressions of prognostic genes were verified by RT-qPCR. Then, a risk model was built and validated by the GSE39582. Independent prognostic factors were screened underlying risk scores and different clinical indicators, resulting in the construction of a nomogram. Additionally, immune infiltration, immune scores and immune checkpoint inhibitors analyses and gene set enrichment analysis (GSEA) were carried out.
Results
The 3,668 JAK-STAT-DEGs were obtained by intersection of 5,826 CRC-DEGs and 9,766 JAK-STAT key module genes. Five prognostic genes were selected (ANK3, F5, FAM50B, KLHL35, MPP2), and their expressions were significantly different between CRC and control groups. A risk model was constructed according to prognostic genes and verified by GSE39582. In addition, the nomogram exhibited superior predictive accuracy for CRC. Furthermore, immune analysis results indicated a notable positive correlation between risk score and the scores of immune (R = 0.486), stromal (R = 0.309), and ESTIMATE (R = 0.422). Immune checkpoint inhibitor ADORA2A (Cor = 0.483263) exhibited the strongest positive correlation with risk score. And MPP2 exhibited the most potent activating influence on the cell cycle pathway, whereas ANK3 demonstrated the most significant inhibitory effect within the apoptosis pathway.
Conclusions
A new JAK-STAT related CRC prognostic model was constructed and validated, which possessed an underlying predictive potential for CRC patients' prognosis and could potentially enhance tailored guidance for immunotherapy.
The Impact of Serum Estradiol Levels on Vaginal pH and Candida Infections During Infertility Treatment
Authors: Çakırgöz Çağın , Çakırgöz Emine , Kirmiç Dilara , Hasdemir Pınar Solmaz , Değerli Kenan
Published: November 2024

Purpose:
This study aims to investigate the potential impact of serum estradiol levels on vaginal pH, flora, and susceptibility to Candida infections in patients undergoing infertility treatment.
Methods:
Clinical data and biochemical parameters were evaluated from 60 infertility patients aged 20–49. Blood serum estradiol levels were measured on the 2nd day of the menstrual cycle along with assessments of vaginal pH and mycological cultures. These procedures were repeated post-ovulation induction at peak estradiol levels. A comparative analysis of pre- and post-treatment samples from the same patients was conducted to determine the effect of increased estradiol on vaginal pH and Candida growth. Statistical analyses were performed using SPSS 22.0 software, with significance set at p < 0.05.
Results:
Post-treatment measurements indicated a significant increase in serum estradiol and vaginal pH compared to pre-treatment levels. Despite this, no significant correlation was found between estradiol levels and changes in vaginal pH, vulvovaginal symptoms, or culture growth. Similarly, vaginal pH levels did not significantly affect vulvovaginal symptoms or Candida culture growth. However, a significant relationship was identified between pre-treatment cultures and vulvovaginal symptoms, a correlation absent in post-treatment samples.
Conclusion:
The findings suggest that the substantial increase in serum estradiol levels during infertility treatment does not predispose patients to vaginal Candida infections via alterations in vaginal pH. There appears to be no additional risk of candidal infections associated with elevated estradiol during infertility treatments.
Dysfunctional crosstalk between macrophages and fibroblasts under LPS-infected and hyperglycemic environment in diabetic wounds
Authors: Sharma Shivam , Kishen Anil
Published: November 2024

Diabetic wounds, especially diabetic foot ulcers, present a major clinical challenge due to delayed healing and prolonged inflammation. Macrophage-fibroblast interactions are essential for wound repair, yet this crosstalk is disrupted in diabetic wounds due to hyperglycemia and bacterial infection. This study investigates the dysfunctional communication between macrophages and fibroblasts, focusing on autocrine, paracrine, and juxtacrine signaling in simulated diabetic environments. Using monoculture and co-culture models of THP-1-derived macrophages and primary human dermal fibroblasts, we simulated conditions of normal glucose, LPS-induced infection, high glucose (with AGEs), and combined high glucose (with AGEs) and LPS. Macrophages in hyperglycemic and LPS-infected environments exhibited a pro-inflammatory M1 phenotype with elevated expression of CD80, and STAT1 and increased production of IL-1β, TNF-α, and MMP9. Fibroblast migration was significantly impaired under high glucose conditions, particularly in paracrine model. Secretome profiling showed heightened pro-inflammatory cytokines and proteases, with reduced anti-inflammatory markers (IL-10 and VEGF-A) under hyperglycemic conditions. Paracrine signaling exacerbated the inflammatory response, while juxtacrine signaling showed more moderate effects, conducive to healing. These findings highlight the pathological macrophage-fibroblast crosstalk in diabetic wounds, particularly under hyperglycemic and LPS-infected conditions, offering insights for potential immunomodulatory therapies aimed at restoring effective signaling and improving wound healing outcomes.
STEM Teacher Candidates’ Preparation for Online Teaching: Promoting Technological and Pedagogical Knowledge
Authors: Estaiteyeh Mohammed , DeCoito Isha , Takkouch Mariam
Published: November 2024

Emergency remote teaching during the COVID-19 pandemic has shed light on pedagogical challenges that require the immediate attention of teacher education programs. This paper focuses on teacher candidates’ preparation to teach online in a STEM curriculum and pedagogy course in a teacher education program at a Canadian university. The authors present a two-phase study of two cohorts of teacher candidates enrolled in this course and explore 1) their perceptions of the dynamics and effectiveness of online teaching as a teaching modality, and 2) the impact of the course on their technological and pedagogical skills necessary for online teaching. Quantitative and qualitative data were collected through pre- and post-surveys administered online at the beginning and end of the course. Findings suggest that teacher candidates’ engagement with course content resulted in a notable improvement in their views toward online teaching as a teaching modality, pedagogical approaches, and personal abilities utilizing innovative online teaching strategies. This research emphasizes the necessity for comprehensive training programs that enhance teacher candidates’ technological competencies while simultaneously refining their pedagogical methodologies for online settings. Implications for teacher education research and practice are discussed.
Déroulement et retombées de projets bricoleur (maker) à l’élémentaire : une revue de la portée
Authors: Cotnam-Kappel Megan , Cattani-Nardelli Alison , Neisary Sima , Labelle Patrick R.
Published: November 2024

Le mouvement bricoleur (maker) connaît une popularité croissante dans les écoles du monde entier, mais la recherche, en particulier en français, est encore à un stade émergent. Cet article propose une revue de la portée des projets bricoleur dans les salles de classe de la 4e à la 8e année (secondaire 2) à l’échelle internationale, qui vise à analyser leurs descriptions, le déroulement, les outils utilisés et les retombées sur les élèves et le personnel enseignant. Sur 1 900 études initialement recensées et 68 articles scientifiques retenus aux fins d’analyse, l’étude définit trois phases principales des projets bricoleur : 1) l’inspiration et la préparation, 2) la mise en œuvre et la réalisation, et 3) la présentation et la recontextualisation, et elle souligne l’équilibre entre les outils numériques et physiques dans les études du corpus. Elle examine aussi les retombées sur les élèves à travers les dimensions affectives, sociales, disciplinaires et métacognitives, ainsi que sur le personnel en ce qui a trait aux dimensions pédagogiques, affectives et sociales. Des exemples de projets bricoleur disciplinaires, interdisciplinaires et transdisciplinaires sont présentés, illustrant l’ampleur et le potentiel du mouvement bricoleur. Ces résultats sont essentiels pour renforcer la formation enseignante, en s’appuyant sur les recommandations issues de recherches récentes, afin de favoriser la conception et l’intégration de projets bricoleur dans les salles de classe.
Technology and Teacher Education in Canada
Authors: Estaiteyeh Mohammed , Cotnam-Kappel Megan , Vaughan Norman
Published: November 2024

Technology and Teacher Education is part of the Canadian Association of Teacher Education (CATE), a constituent of the Canadian Society for the Study of Education (CSSE). Its mission is to foster a collaborative network of educational researchers dedicated to exploring the intersections of technology and teacher education in Canada. Aligning with this mission, this special issue showcases Canadian scholar expertise and amplifies the diverse voices of the TATE community.
Inspired by discussions held during our annual TATE conference, where we focused on lessons learned from emergency remote teaching during the COVID-19 pandemic and the rapid technological advancements that teacher education programs are navigating, this issue offers a collection of studies from Canadian researchers working to make teaching and learning with digital technologies more effective, inclusive, and equitable for all Canadians.
Producción, bloqueo y reapropiación de la experiencia en la esfera pública. Una actualización de Marx a través de Kluge y Negt
Authors: Giraldo Ramírez Jorge Iván , Santamaría Moncada Manuela
Published: November 2024

Este artículo defiende que la filosofía marxista proporciona importantes herramientas conceptuales para esbozar un concepto crítico de la esfera pública con base en las aportaciones teóricas de Alexander Kluge y Oskar Negt. Para ello, se muestra, en primer lugar, que el concepto de producción de Marx tiene una dimensión simbólica inherente y que no solo abarca la producción de mercancías, sino también la de la experiencia social. A partir de esta idea filosófica de la producción, se examina una relación que no se ha investigado a fondo hasta ahora: aquella entre el proceso de acumulación originaria y la esfera pública. El objetivo es identificar los medios de violencia y desposesión que permiten el dominio de los intereses del capital en la esfera pública. Finalmente, son expuestas algunas relaciones entre teoría y praxis junto con algunas ideas normativas que se derivan de este enfoque materialista de la esfera pública.
Las tríadas dialécticas de la verdad: variaciones de la sustracción en la obra filosófica de Alain Badiou
Authors: Varela Pequeño Mikel
Published: November 2024

La sustracción es una categoría fundamental en la filosofía de Alain Badiou para pensar tanto el ser como los procedimientos de verdad. Sobre ella se sostiene un concepto de “verdad” postfundacional que elude el esencialismo y se muestra irreductible a las teorías de la coherencia, la correspondencia y la confirmación. Este artículo indaga sobre el papel que la categoría de “sustracción” juega y las formas que adopta en la obra de Alain Badiou, específicamente en lo que a la construcción de los procedimientos de verdad se refiere. El objetivo consiste en sacar a la luz las transformaciones que ha experimentado y los fundamentos racionales y especulativos que la sostienen en cada una de sus variaciones. En concreto, se identifican cuatro variaciones, que se correlacionan con los periodos que marcan la atmósfera conceptual de cada una de las opera magna filosóficas de Badiou (Théorie du sujet, L’être et l’événement, Logiques du mondes y L’immanence des vérités). Se concluye que la sustracción que despliega los procedimientos de verdad se caracteriza por establecer una relación dialéctica triádica con la afirmación y la negación, pero cuyo equilibrio es dinámico, con una idiosincrasia propia en cada una de esas variaciones.
Diagnostic study of the transformation of educational internships in three public Islamic Universities in Indonesia
Authors: Ansyah Edi , Salamah Salamah , Rahman Alvin Yanuar , Rahmat Azwar
Published: November 2024

This study aims to diagnose the transformation of educational internship programs in three State Islamic Universities (UIN), namely UIN Fatmawati Sukarno Bengkulu, UIN Syarif Hidayatullah Jakarta, and UIN Sunan Gunung Djati Bandung. The main focus of the research is to understand the changes that occur in the implementation of educational internships, the supporting and inhibiting factors of transformation, as well as the impact on students and institutions. The research method used was a diagnostic study with a qualitative approach. Data were collected through in-depth interviews, observations, and document analysis related to the internship program. The results showed that the transformation of the educational internship program involved significant changes in the curriculum, increased student involvement, and the use of technology in teaching. The main supporting factors include Merdeka Belajar-Kampus Merdeka policy support, supporting technology, and university commitment while inhibiting factors include variations in the quality of partner schools, limited technological infrastructure, and curriculum adjustment constraints. This transformation has a positive impact on improving students' teaching skills, better work readiness, and strengthening the university's academic reputation.
PENGARUH PERKEMBANGAN TEKNOLOGI, KUALITAS SDM, PERTUMBUHAN EKONOMI, DAN INVESTASI TERHADAP TPT
Authors: Firdausi Ismy Angeia
Published: November 2024

Unemployment is a macro problem that grows due to the imbalance between economic growth and increased employment. East Java Province made various efforts to reduce the open unemployment rate. To overcome the unemployment problem in East Java, several indicators are of concern to be studied, namely technological development, quality of human resources (HR), economic growth, and investment in 2015-2022. The purpose of this study is to findout the factors that can affect TPT in East Java.  This study uses panel data, through classical assumption tests to hypothesis tests, with secondary data types coming from the official website of BPS (Central Statistics Agency). The estimation results suggest that technological developments, the quality of human resources, and investment tend to increase the number of TPT in East Java. Meanwhile, economic growth tends to reduce the TPT figure in East Java. This research can be a learning material about unemployment.
PENGARUH PERTUMBUHAN EKONOMI, PENDIDIKAN, DESENTRALISASI FISKAL, DAN BELANJA MODAL TERHADAP KETIMPANGAN PENDAPATAN
Authors: Putri Nabila Dewi
Published: November 2024

Despite the major economic contribution of Java, some economic problems persist; one of which is income inequality in five regencies and cities in the Special Region of Yogyakarta. The objective of this research is to examine the effects of economic growth, education, degree of fiscal decentralization, and capital expenditures on income inequality in the Special Region of Yogyakarta during the 2011-2021 period. The results of the analysis using panel data regression with Common Effect Model indicate that education and degree of fiscal decentralization significantly affect income inequality in the Special Region of Yogyakarta during the 2011-2021 period, while economic growth and capital expenditures have no significant impact on the income inequality in the said region during the aforementioned period.
Transforming classroom dynamics: A comparative analysis of U-style, V-style, and circle innovative teaching techniques
Authors:   Faculty of Language and Communication, Sultan Idris Education University, Perak, Malaysia, Sivanathan Ilankumaran , Thamburaj Kingston Pal ,   Faculty of Language and Communication, Sultan Idris Education University, Perak, Malaysia, Ponniah Kartheges ,   Faculty of Language and Communication, Sultan Idris Education University, Perak, Malaysia, Arumugum Logeswary ,   SMK Pokok Sena, Pulau Pinang, Malaysia, Rajamani Ravi ,   Michael Job Memorial College of Education for Women, Tamilnadu, India
Published: November 2024

This research paper examines three distinct teaching methods—U-Style, V-Style, and Circle—and analyzes their impact on student participation, collaboration, and learning outcomes. The study involved 30 students enrolled in a Tamil degree program, with the seating arrangement used in a Tamil classical literature class. Both qualitative and quantitative methods were used to evaluate the impact of these seating styles. Data was collected through observation, tests, and student feedback. The findings suggest that cluster seating is particularly effective in creating a student-centered classroom. This setup promotes collaborative learning and improves student engagement and learning outcomes. The study emphasizes the importance of well-planned seating arrangements in the classroom. Using cluster seating can help create an active and cooperative learning environment, supporting the goals of modern education.
چارەنووسی قودس لە جەنگ و ڕێككەوتنەكانی پادشا ئەیوبییەكاندا (583 - 642 ك/ 1187 - 1244ز)
Authors: Muhammed Yaseen Taha
Published: November 2024

مەبەست لەم توێژینەوەیە دەرخستنی ئەو بارگۆڕانانەیە كە بەسەر شوناس و بارودۆخی شاری قودسدا هاتوون لە هەڵكشان و داكشانەكانی دەوڵەتی ئەیوبیدا، هەر لە گێڕانەوەی "شارە پیرۆز" ـەكەوە بۆ سایەی حوكمڕانی ئیسلامی لە سەردەمی سوڵتان سەلاحەدین (583ك/1187ز)، تا دەگاتە ڕادەستكردنەوەی بە خاچییەكان لە دوو ڕێككەوتندا؛ یەكەمیان لەلایەن "مەلیك كامیل"ی برازا و زاوای "سەلاحەدین" (626ك/1229ز)، دووەمجاریش لەلایەن سێ پادشای ئەیوبی لە برازا جێنشینەكانی دیكەی كە حوكمڕانی شام بوون (642ك/ 1244ز). پێدراوە مێژوییەكانی توێژینەوەكە ئەوە دەردەخەن ئەو گرنگییەی "سەلاحەدینی ئەیوبی" بە گێڕانەوەی قودسی داوە كە ئامانجێكی  گەورە و سەرانسەری بووە لەسەر ئاستی جیهانی ئیسلامی، هەروەها ئەو هێزەشی كە گێڕانەوەی ئەم شارە بە دامەزرێنەری دەوڵەتی ئەیوبی بەخشیوە، لە سەردەمی جێنشینەكانیدا، لەلایەك بەهۆی خەمساردی و لە لایەكی تر بەهۆی ململانێی نێوخۆیی لەسەر دەسەڵات و هەروەها گۆڕانی بارودۆخ و هەلومەرجیشەوە؛ گۆڕانی گەورەی بەسەردا هاتووە، بەم هۆیەشەوە دەستكەوتە گرنگەكەی "سەلاحەدینی ئەیوبی" كراوەتە كارتێك بۆ ڕێككەوتن لەگەڵ خاچییەكان و هۆكارێك بۆ سەركەوتن و باڵادەستی بەسەر یەكتریدا، ئەمەش ڕەخنە و توڕەیی زۆری هێناوەتە جێنشینەكانی "سوڵتان سەلاحەدین" چونكە نەیانتوانی پارێزگاری لەم دەستكەوتە گەورەیە بكەن و لە بری ئەوە بە ناكۆكی و پەرتەوازەیی و هەوڵی زاڵبوون بەسەر یەكدا سەرقاڵبوون. میتۆدی توێژینەوەكەش مێژویی  شیكارییە و تیشك دەخاتە سەر مامەڵەی پادشا ئەیوبییەكان لەگەڵ پرسێكی هەستیار لە قۆناغی پاش فەرمانڕەوایی"سەلاحەدینی ئەیوبی" كە دۆسیەی شاری قودسی كێشە لەسەرە.
Deterioration of health of infants during the war and COVID-19 pandemic in Ukraine
Authors: Volosovets O.P. , Kryvopustov S.P. , Kuzmenko A.Ya. , Prokhorova M.P. , Chernii O.F. , Khomenko V.Ye. , Iemets O.V. , Gryshchenko N.V. , Kovalchuk O.L. , Kupkina A.V.
Published: November 2024

Background. The coronavirus disease 2019 ­(COVID-19) pandemic and the war have significantly affected the state of national medical systems and the health of the population, especially children. The purpose of the study is to analyze the impact of the war and pandemic consequences on the health status of children in the first year of life from 2020 to 2023 in Ukraine. ­Materials and methods. A retrospective analysis of the birth rate and the number of children in Ukraine, the frequency of breastfeeding, and the morbidity of children in the first year of life in Ukraine from 2020 to 2023 was conducted according to the data of the Public Health Centre of the Ministry of Health of Ukraine. Methods of systematic approach and epidemiological analysis were used. Results. In the last four years during the war and the ­COVID-19 pandemic, the number of children in Ukraine decreased to 5.5 million, or by 19.3 %, compared to 2020. The number of infants decreased even more, by 43.06 %, due to a 30.5 % decrease in the birth rate compared to 2020 (p < 0.01). The proportion of children who stopped breastfeeding at 3 months increased by 11.67 % between 2020 and 2023, while the number of those who stopped breastfeeding at 6 months decreased slightly, by 3.97 %. The largest increase in the proportion of children who stopped breastfeeding at these ages was observed in the Donetsk, Luhansk and Zapo­rizhzhia regions, where the most intense hostilities are taking place. An increase in the morbidity rate among children in the first year of life to 1463.5 ‰, or by 19.9 % compared to 2020, and its return to the levels observed in the middle of the last decade indicate the negative impact of direct and indirect war-related factors on the health status of children in the first year of life, and, probably, a limited access to health care in areas where hostilities continue and those been de-occupied. Respiratory diseases, especially acute upper respiratory diseases, pneumonia, influenza, certain perinatal conditions, diseases of the skin and subcutaneous tissues, digestive disorders, nervous system and blood diseases are the main causes of morbidity among children in the first year of life. Conclusions. The war and the consequences of the COVID-19 pandemic have had a negative impact on the birth rate, the number of the child population in Ukraine. Morbidity rates among infants have increased, and breastfeeding rates and vaccination coverage have decreased.
Endometriosis in adolescents
Authors: Fedorenko O.V. , Ocheretna Yu.S. , Tarnovska H.P.
Published: November 2024

Endometriosis is one of the most significant disorders affecting women of all ages, including adolescents. Its prevalence is estimated at an average of 15 %, but data in adolescents is lac­king and the real data may be significantly higher. Endometriosis in adolescents is a global medical, social and economic problem, as the associated symptoms worsen the quality of life, reduce the level of socialization, have negative impact on health indicators and quality of life, affect future reproductive capabilities and increase economic costs. For a long time, endometriosis was considered as a disease of women of reproductive age; however, now it is known that it affects women of all ages. In adolescent girls, endometriosis is understudied, sometimes ignored, or unrecognized that leads to delays in diagnosis and, consequently, in treatment. The aim of this review was to analyze clinical manifestations of endometriosis in adolescents, factors associated with the risk of development and progression of the disease, and the peculiarities of diagnosis and treatment in adolescence. Understanding the features of this disease, its symptoms, diagnosis, and treatment in adolescents will significantly improve the quality of life, control the disease, and enhance future reproductive capabilities.