bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of the fungicidal activity of the aqueous extracts of some medicinal plants against Fusarium spp
Authors: Salim Hussein , Alsaady Majida , Al-zuhairi Abdulsattar , Kassoub Fahmy
Published: July 2023

To assess the performance of the aqueous extracts of Rhus coriaria, Boswellia carterii, Nigella sativa and Aloe vera. Three concentrations (5%, 10%, and 15%) for each extract were tested in vitro for their activity against three isolates of Fusarium spp. All extracts have a high inhibitory capacity against tested isolates. An inhibition percentage for selected isolates was increased with concentrations (5%, 10%, 15%). The concentration of Rhus coriaria extract 15 % resulted in a significant increase in inhibition percentage of mycelial growth of Fusarium sp.1 (63.17%), Fusarium sp2 (61.69%) and Fusarium sp3 (59.35%) compared to other concentrations, the concentration of Boswellia carterii extract 10% led to a significant increase in inhibition percentage of mycelial growth of Fusarium sp2 (82.45 %) compared to concentration 5% (73.67 %), the concentration of Nigella sativa extract 15% was recorded high inhibition percentage in Fusarium sp2 (66.15 %) compared to concentration 5% (22.21%). In contrast, concentrations 5% and 10% were recorded highest inhibition percentages in Fusarium sp3, reaching 31.73 % and 22.02%, respectively, compared to concentration 15% (4.90%).
Keywords: Rhus coriaria, Boswellia carterii, Nigella sativa, Aloe vera and Fusarium spp
Isolation and diagnosis of some associated fungi with cowpea root rot disease and testing its pathogenicity
Authors: Jassim Awad Ahmed , A.Farhan Theyab
Published: July 2023

Execute search by date 1/4/2021, The results of collecting samples from the regions of Anbar, Baghdad, Salah al-Din and Wasit showed that cowpea root rot disease is widespread in all studied areas, and The results of isolation phenotypic and molecular diagnosis showed the presence of different isolation of fungi that infected cowpea root, such as Fusarium nygamai (Fu1), F. nygamai (Fu2), F. solani (Fu3), F. solani(Fu4), Rhizoctonia solani (Rh5), and Fusarium solani (Fu6), The results of the pathogenicity test on radish seeds showed that tested isolates were significantly decreased germination percentage of radish seeds of water Ager, and the most effective isolation was F. solani (Fu4). The infection rate was 90% compared to 0.00% of the control media treatment, which was uncontaminated by the pathogenic fungus. Isolated fungi showed a difference in the percentage and severity of infection on cowpea seedlings and seedlings, as the isolate of F.nygamai (Fu1) achieved the highest infection rate of 66.67 % and the severity of disease at 75%. All fungal isolates significantly increased the rate and severity of infection on seed radish compared with the control treatment not contaminated with pathogenic fungi by 0.0%.
Keywords: Vegan unguiculata; Rhizoctonia solani; and Fusarium solani; PCR.
Effect of adding chemical and organic fertilizers and spraying seaweed extracts on NPKS concentrations and cauliflower yield
Authors: Rahman Saleh Auf Abdul , Rahem Bader Basem
Published: July 2023

A field experiment was carried out in the agricultural season 2021-2022 in one of the agricultural fields in the Muqdadiya, Al-Harouniya district, located 40 km northeast of the Baquba district of Diyala governorate. The agrarian soil was classified as silty clay (Soil Survey Staff, 2006). It is located at a longitude of 53° 34’ N and latitude of 56° 04° 45° S. The experiment aimed to study the effect of adding chemical and organic fertilizers and spraying seaweed extracts on NPKS concentrations and cauliflower yield. The investigation included three factors: adding organic fertilizer (buffalo waste) at three levels (0, 5 and 10)% of the terrace’s size, symbolized by M1, M2 and 3M, respectively. It was added at a depth of 0-30 cm a month before planting the seedlings in the field. The second factor was the addition of NPK compound chemical fertilizer (20:20:20) at two levels (0 and the full fertilizer recommendation is 300 kg H-1 when planted as a feed) and symbolized by 1 C and 2 C, respectively. The third factor is spraying seaweed extract with three levels (0, 2 and 4) ml L-1 illustrated by A1, A2 and according to an RCBD randomized complete block design with three replications. The experiment results showed that adding organic fertilizer (10% of the size of the terrace) led to a significant increase in the head’s weight, reaching 1.611 kg. The results of the experiment showed that the addition of organic fertilizer (10% of the size of the terrace) led to a significant increase in the weight of the head, as it reached 1.611 kg plant-1, the sulfur concentration in the fruits was 2.00 mg sulfur kg-1, the nitrogen concentration in the leaves was 4.68%. The phosphorous concentration in the leaves was 25%, and the potassium concentration in the leaves was 2.05%; chemical fertilization also increased head weight from 1.385 kg. Plant-1 to 1,108 kg Plant-1.There was an increase in each of the sulfur concentrations in fruits from 2.00% to 1.53%, in the nitrogen concentration in the leaves from 4.60% to 3.48% and an increase in the phosphorous concentration in the leaves from 0.37% to 0.26% and an increase in the potassium concentration in the leaves from 2.78% to 2.27 %, spraying seaweed extracts at a concentration of 4 mmol. L-1 led to a significant increase in head weight, which reached 1.282 kg. Plant-1, nitrogen concentration in leaves 803% and potassium concentration in leaves 2.58%.As for the triple interaction
.Keywords: chemical fertilization, organic fertilization, seaweed extracts, cauliflower.
Evaluating the Effects of Rewards and Schedule Length on Response Rates to Ecological Momentary Assessment Surveys: Randomized Controlled Trials
Authors: Edney Sarah , Goh Claire Marie , Chua Xin Hui , Low Alicia , Chia Janelle , S Koek Daphne , Cheong Karen , van Dam Rob , Tan Chuen Seng , Müller-Riemenschneider Falk
Published: July 2023

Background

Ecological momentary assessments (EMAs) are short, repeated surveys designed to collect information on experiences in real-time, real-life contexts. Embedding periodic bursts of EMAs within cohort studies enables the study of experiences on multiple timescales and could greatly enhance the accuracy of self-reported information. However, the burden on participants may be high and should be minimized to optimize EMA response rates.

Objective

We aimed to evaluate the effects of study design features on EMA response rates.

Methods

Embedded within an ongoing cohort study (Health@NUS), 3 bursts of EMAs were implemented over a 7-month period (April to October 2021). The response rate (percentage of completed EMA surveys from all sent EMA surveys; 30-42 individual EMA surveys sent/burst) for each burst was examined. Following a low response rate in burst 1, changes were made to the subsequent implementation strategy (SMS text message announcements instead of emails). In addition, 2 consecutive randomized controlled trials were conducted to evaluate the efficacy of 4 different reward structures (with fixed and bonus components) and 2 different schedule lengths (7 or 14 d) on changes to the EMA response rate. Analyses were conducted from 2021 to 2022 using ANOVA and analysis of covariance to examine group differences and mixed models to assess changes across all 3 bursts.

Results

Participants (N=384) were university students (n=232, 60.4% female; mean age 23, SD 1.3 y) in Singapore. Changing the reward structure did not significantly change the response rate (F3,380=1.75; P=.16). Changing the schedule length did significantly change the response rate (F1,382=6.23; P=.01); the response rate was higher for the longer schedule (14 d; mean 48.34%, SD 33.17%) than the shorter schedule (7 d; mean 38.52%, SD 33.44%). The average response rate was higher in burst 2 and burst 3 (mean 50.56, SD 33.61 and mean 48.34, SD 33.17, respectively) than in burst 1 (mean 25.78, SD 30.12), and the difference was statistically significant (F2,766=93.83; P<.001).

Conclusions

Small changes to the implementation strategy (SMS text messages instead of emails) may have contributed to increasing the response rate over time. Changing the available rewards did not lead to a significant difference in the response rate, whereas changing the schedule length did lead to a significant difference in the response rate. Our study provides novel insights on how to implement EMA surveys in ongoing cohort studies. This knowledge is essential for conducting high-quality studies using EMA surveys.

Trial Registration

ClinicalTrials.gov NCT05154227; https://clinicaltrials.gov/ct2/show/NCT05154227
Longer-Term Effects of Cardiac Telerehabilitation on Patients With Coronary Artery Disease: Systematic Review and Meta-Analysis
Authors: Zhong Wen , Liu Rui , Cheng Hongxin , Xu Lin , Wang Lu , He Chengqi , Wei Quan
Published: July 2023

Background

Cardiac telerehabilitation offers a flexible and accessible model for patients with coronary artery disease (CAD), effectively transforming the traditional cardiac rehabilitation (CR) approach.

Objective

This systematic review and meta-analysis aimed to evaluate the long-term effectiveness of cardiac telerehabilitation.

Methods

We searched randomized controlled trials (RCTs) in 7 electronic databases: PubMed, Web of Science, EMBASE, the Cochrane Central Register of Controlled Trials, ClinicalTrials.gov, the China National Knowledge Infrastructure, and WANFANG. The primary outcome focused on cardiopulmonary fitness. For secondary outcomes, we examined cardiovascular risk factors (blood pressure, BMI, and serum lipids), psychological scales of depression and anxiety, quality of life (QoL), cardiac telerehabilitation adherence, and adverse events.

Results

In total, 10 RCTs fulfilled the predefined criteria, which were reviewed in our meta-analysis. The results showed that after cardiac telerehabilitation, there was a significant difference in the improvement in long-term peak oxygen uptake compared to center-based CR (mean difference [MD] 1.61, 95% CI 0.38-2.85, P=.01), particularly after 6-month rehabilitation training (MD 1.87, 95% CI 0.34-3.39, P=.02). The pooled effect size of the meta-analysis indicated that there were no significant differences in the reduction in cardiovascular risk factor control. There was also no practical demonstration of anxiety scores or depression scores. However, cardiac telerehabilitation demonstrated an improvement in the long-term QoL of patients (MD 0.92, 95% CI 0.06-1.78, P=.04). In addition, the study reported a high completion rate (80%) for cardiac telerehabilitation interventions. The incidence of adverse events was also low during long-term follow-up.

Conclusions

Cardiac telerehabilitation proves to be more effective in improving cardiopulmonary fitness and QoL during the long-term follow-up for patients with CAD. Our study highlights monitoring-enabled and patient-centered telerehabilitation programs, which play a vital role in the recovery and development of CAD and in the long-term prognosis of patients.
Perceptions of COVID-19 and the Use of Health Information Technology Among People Who Are Uninsured: Multimethod Survey Study (Preprint)
Authors: Patel Khushi S , Corbett Cynthia F , Combs Elizabeth M , Donevant Sara B , Selph Margaret J , Gibson Lynette M , Dawson Robin M , Sheth Amit P , Hughes Ronda G
Published: July 2023

BACKGROUND

As of May 2023, the novel SARS-CoV-2 has claimed nearly 7 million lives globally and >1.1 million lives in the United States. Low-income populations are often disproportionately affected by risk factors such as lifestyle, employment, and limited health literacy. These populations may lack the knowledge of appropriate infection precautions or have reduced access to care during illness, particularly in countries without universal health care.

OBJECTIVE

We aimed to explore the perceptions and experiences of COVID-19, including symptoms and risk factors among uninsured individuals seeking care at a free medical clinic, and to obtain respondents’ perceptions of and suggestions for adapting a mobile health (mHealth) app to an uninsured population known to have low health literacy.

METHODS

We conducted a prospective multimethod survey study with a convenience sample of uninsured adults seeking care at 3 free clinics in the United States. Respondents were questioned about their risk for and awareness of COVID-19 symptoms, COVID-19 testing, current technology use, and the use of technology to facilitate their health regarding COVID-19. Data were analyzed using descriptive statistics (eg, frequencies and mean differences). In addition, a small subset of respondents from one of the clinics (n=10) participated in interviews to provide feedback about the design of a COVID-19 web-based smartphone (mHealth) app.

RESULTS

The survey respondents (N=240) were 53.8% (n=129) female, were primarily White (n=113, 47.1%), and had a mean age of 50.0 (SD 11.67; range 19-72) years. Most respondents (162/222, 73%) did not think that they were at risk for COVID-19. Although respondents reported only moderate confidence in their knowledge of the short- and long-term symptoms of COVID-19, their knowledge of the symptoms aligned well with reports published by the Centers for Disease Control and Prevention of the most common acute (590/610, 96.7%) and long-term (217/271, 80.1%) symptoms. Most respondents (159/224, 71%) reported an interest in using the mHealth app to gain additional information regarding COVID-19 and available community resources. Respondents who were interviewed provided suggestions to improve the mHealth app but had overall positive perceptions about the potential usefulness and usability of the app.

CONCLUSIONS

It was encouraging that the knowledge of COVID-19 symptoms aligned well with the reports published by the Centers for Disease Control and Prevention and that respondents were enthusiastic about using an mHealth app to monitor symptoms. However, it was concerning that most respondents did not think they were at a risk of contracting COVID-19.
The Effects of Adopting Mobile Health and Fitness Apps on Hospital Visits: Quasi-Experimental Study (Preprint)
Authors: Bo Yan , Liu Qianqian Ben , Tong Yu
Published: July 2023

BACKGROUND

Overcrowding in public hospitals, a common issue in many countries, leads to a range of negative outcomes, such as insufficient access to medical services and patient dissatisfaction. Prior literature regarding solutions to reducing hospital overcrowding primarily focuses on organizational-level operational efficiency. However, few studies have investigated the strategies from the individual patient perspective. Specifically, we considered using mobile health and fitness apps to promote users’ health behaviors and produce health benefits, thereby reducing hospital visits.

OBJECTIVE

This study estimated the causal effect of health and fitness app adoption on hospital visits by exploiting the staggered timing of adoption. We also investigated how the effect varied with users’ socioeconomic status and digital literacy. This study provides causal evidence for the effects of health apps, extends the digital health literature, and sheds light on mobile health policies.

METHODS

This study used a data set containing health and fitness app use and hospital-related geolocation data of 267,651 Chinese mobile phone users from January to December 2019. We used the difference-in-differences and difference-in-difference-in-differences designs to estimate the causal effect. We performed a sensitivity analysis to establish the robustness of the findings. We also conducted heterogeneity analyses based on the interactions of postadoption indicators with users’ consumption levels, city tiers, and digital literacy.

RESULTS

The preferred model (difference-in-difference-in-differences) showed a significant decrease in hospital visits after the adoption of health and fitness apps. App adoption led to a 5.8% (P<.001), 13.1% (P<.001), and 18.4% reduction (P<.001) in hospital visits 1, 2, and 3 months after adoption, respectively. In addition, the moderation analysis shows that the effect is greater for users with high consumption levels, in high-tier cities, or with high digital literacy.

CONCLUSIONS

This study estimated the causal effect of health and fitness app adoption on hospital visits. The results and sensitivity analysis showed that app adoption can reduce users’ hospital visits. The effect varies with users’ consumption levels, city tiers, and digital literacy. These findings provide useful insights for multiple stakeholders in the Chinese health care context.
The Impact of Intervention Design on User Engagement in Digital Therapeutics Research: Factorial Experiment With a Mixed Methods Study (Preprint)
Authors: Lee Hyerim , Choi Eung Ho , Shin Jung U , Kim Tae-Gyun , Oh Jooyoung , Shin Bokyoung , Sim Jung Yeon , Shin Jaeyong , Kim Meelim
Published: July 2023

BACKGROUND

User engagement is crucial for digital therapeutics (DTx) effectiveness; due to variations in the conceptualization of engagement and intervention design, assessment and retention of engagement remain challenging.

OBJECTIVE

We investigated the influence of the perceived acceptability of experimental intervention components and satisfaction with core intervention components in DTx on user engagement, while also identifying potential barriers and facilitators to user engagement.

METHODS

We conducted a mixed methods study with a 2 × 2 factorial design, involving 12 outpatients with atopic dermatitis. Participants were randomized into 4 experimental groups based on push notification (“basic” or “advanced”) and human coach (“on” or “off”) experimental intervention components. All participants engaged in self-monitoring and learning courses as core intervention components within an app-based intervention over 8 weeks. Data were collected through in-app behavioral data, physician- and self-reported questionnaires, and semistructured interviews assessed at baseline, 4 weeks, and 8 weeks. Descriptive statistics and thematic analysis were used to evaluate user engagement, perceived acceptability of experimental intervention components (ie, push notification and human coach), satisfaction with core intervention components (ie, self-monitoring and learning courses), and intervention effectiveness through clinical outcomes.

RESULTS

The primary outcome indicated that group 4, provided with “advanced-level push notifications” and a “human coach,” showed higher completion rates for self-monitoring forms and learning courses compared to the predetermined threshold of clinical significance. Qualitative data analysis revealed three key themes: (1) perceived acceptability of the experimental intervention components, (2) satisfaction with the core intervention components, and (3) suggestions for improvement in the overall intervention program. Regarding clinical outcomes, the Perceived Stress Scale and Dermatology Life Quality Index scores presented the highest improvement in group 4.

CONCLUSIONS

These findings will help refine the intervention and inform the design of a subsequent randomized trial to test its effectiveness. Furthermore, this design may serve as a model for broadly examining and optimizing overall engagement in DTx and for future investigation into the complex relationship between engagement and clinical outcomes.

CLINICALTRIAL

Clinical Research Information Service KCT0007675; http://tinyurl.com/2m8rjrmv
An Infrastructure Framework for Remote Patient Monitoring Interventions and Research (Preprint)
Authors: Claggett Jennifer , Petter Stacie , Joshi Amol , Ponzio Todd , Kirkendall Eric
Published: July 2023

UNSTRUCTURED

Remote patient monitoring (RPM) enables clinicians to maintain and adjust their patients’ plan of care by using remotely gathered data, such as vital signs, to proactively make medical decisions about a patient’s care. RPM interventions have been touted as a means to improve patient care and well-being while reducing costs and resource needs within the health care ecosystem. However, multiple interworking components must be successfully implemented for an RPM intervention to yield the desired outcomes, and the design and key driver of each component can vary depending on the medical context. This viewpoint and perspective paper presents a 4-component RPM infrastructure framework based on a synthesis of existing literature and practice related to RPM. Specifically, these components are identified and considered: (1) data collection, (2) data transmission and storage, (3) data analysis, and (4) information presentation. Interaction points to consider between components include transmission, interoperability, accessibility, workflow integration, and transparency. Within each of the 4 components, questions affecting research and practice emerge that can affect the outcomes of RPM interventions. This framework provides a holistic perspective of the technologies involved in RPM interventions and how these core elements interact to provide an appropriate infrastructure for deploying RPM in health systems. Further, it provides a common vocabulary to compare and contrast RPM solutions across health contexts and may stimulate new research and intervention opportunities.
Prediction of Antibiotic Resistance in Patients With a Urinary Tract Infection: Algorithm Development and Validation (Preprint)
Authors: İlhanlı Nevruz , Park Se Yoon , Kim Jaewoong , Ryu Jee An , Yardımcı Ahmet , Yoon Dukyong
Published: July 2023

BACKGROUND

The early prediction of antibiotic resistance in patients with a urinary tract infection (UTI) is important to guide appropriate antibiotic therapy selection.

OBJECTIVE

In this study, we aimed to predict antibiotic resistance in patients with a UTI. Additionally, we aimed to interpret the machine learning models we developed.

METHODS

The electronic medical records of patients who were admitted to Yongin Severance Hospital, South Korea were used. A total of 71 features extracted from patients’ admission, diagnosis, prescription, and microbiology records were used for classification. UTI pathogens were classified as either sensitive or resistant to cephalosporin, piperacillin-tazobactam (TZP), carbapenem, trimethoprim-sulfamethoxazole (TMP-SMX), and fluoroquinolone. To analyze how each variable contributed to the machine learning model’s predictions of antibiotic resistance, we used the Shapley Additive Explanations method. Finally, a prototype machine learning–based clinical decision support system was proposed to provide clinicians the resistance probabilities for each antibiotic.

RESULTS

The data set included 3535, 737, 708, 1582, and 1365 samples for cephalosporin, TZP, TMP-SMX, fluoroquinolone, and carbapenem resistance prediction models, respectively. The area under the receiver operating characteristic curve values of the random forest models were 0.777 (95% CI 0.775-0.779), 0.864 (95% CI 0.862-0.867), 0.877 (95% CI 0.874-0.880), 0.881 (95% CI 0.879-0.882), and 0.884 (95% CI 0.884-0.885) in the training set and 0.638 (95% CI 0.635-0.642), 0.630 (95% CI 0.626-0.634), 0.665 (95% CI 0.659-0.671), 0.670 (95% CI 0.666-0.673), and 0.721 (95% CI 0.718-0.724) in the test set for predicting resistance to cephalosporin, TZP, carbapenem, TMP-SMX, and fluoroquinolone, respectively. The number of previous visits, first culture after admission, chronic lower respiratory diseases, administration of drugs before infection, and exposure time to these drugs were found to be important variables for predicting antibiotic resistance.

CONCLUSIONS

The study results demonstrated the potential of machine learning to predict antibiotic resistance in patients with a UTI. Machine learning can assist clinicians in making decisions regarding the selection of appropriate antibiotic therapy in patients with a UTI.

CLINICALTRIAL
Research Trends and Evolution in Radiogenomics (2005-2023): Bibliometric Analysis (Preprint)
Authors: Wang Meng , Peng Yun , Wang Ya , Luo Dehong
Published: July 2023

BACKGROUND

Radiogenomics is an emerging technology that integrates genomics and medical image–based radiomics, which is considered a promising approach toward achieving precision medicine.

OBJECTIVE

The aim of this study was to quantitatively analyze the research status, dynamic trends, and evolutionary trajectory in the radiogenomics field using bibliometric methods.

METHODS

The relevant literature published up to 2023 was retrieved from the Web of Science Core Collection. Excel was used to analyze the annual publication trend. VOSviewer was used for constructing the keywords co-occurrence network and the collaboration networks among countries and institutions. CiteSpace was used for citation keywords burst analysis and visualizing the references timeline.

RESULTS

A total of 3237 papers were included and exported in plain-text format. The annual number of publications showed an increasing annual trend. China and the United States have published the most papers in this field, with the highest number of citations in the United States and the highest average number per item in the Netherlands. Keywords burst analysis revealed that several keywords, including “big data,” “magnetic resonance spectroscopy,” “renal cell carcinoma,” “stage,” and “temozolomide,” experienced a citation burst in recent years. The timeline views demonstrated that the references can be categorized into 8 clusters: lower-grade glioma, lung cancer histology, lung adenocarcinoma, breast cancer, radiation-induced lung injury, epidermal growth factor receptor mutation, late radiotherapy toxicity, and artificial intelligence.

CONCLUSIONS

The field of radiogenomics is attracting increasing attention from researchers worldwide, with the United States and the Netherlands being the most influential countries. Exploration of artificial intelligence methods based on big data to predict the response of tumors to various treatment methods represents a hot spot research topic in this field at present.
On Environmental Protection and Sustainable Utilization of Land Resources
Authors: Wu Zhonglin
Published: July 2023

In today’s era, with the rapid development of social economy and the rapid increase of urban population, the demand for land resources is becoming increasingly strong. However, as is well known, the land resources on Earth are limited. If we want to achieve long-term development, we must take the path of sustainable development and use land resources sustainably. At the same time, the sustainable use of land resources and environmental protection are also inseparable, and the two are complementary. At present, China should rely on the superiority of the socialist system, mobilize various forces, coordinate planning, highlight key points, and implement step by step, while following natural and economic laws, to achieve the goals of environmental improvement and sustainable land resource utilization as soon as possible.
Writing Motivation, Strategy Use, and Proficiency of Chinese Non-English Majors
Authors: Jingya Zhang
Published: July 2023

This study investigates the interplay of English language motivation, writing strategies, and proficiency among non-English major Chinese university students. A mixed-methods approach reveals a moderate positive correlation between these factors, with both intrinsic and extrinsic motivations and translation strategies standing out as particularly impactful. The study further uncovers distinctive motivational, strategic, and proficiency patterns among different student groups, including sex, school type, academic year, and major divisions. Based on these findings, the Motivation-Strategy-Proficiency-based Writing Enhancement Program (MSP-WEP) is proposed to holistically improve academic writing skills. This research contributes to the understanding of factors affecting English academic writing proficiency in non-English major students and provides a practical program for educators, with a call for future research into the program’s efficacy in diverse learning contexts.
Physical Exercise System Structure with Tools for Preschool Children 4-5 Years old Hanoi City
Authors: Yen Nguyen Thi
Published: July 2023

Structure of physical exercise system with equipment for preschool children 4-5 years old Hanoi City: The structure of the physical exercise system with equipment for 4-year-old preschool children in Hanoi City, of 8 groups with 35 exercises with equipment for the age of 4 is (1) Group of movement exercises; (2) Group of stretching exercises; (3) Group of exercises that stimulate height growth; (4) Group of orientation exercises; (5) Group of exercises for upper limb development; (6) Group of exercises for lower limb development; (7) Group of skillful development exercises; (8) Group of mixed exercises. Structure of physical exercise system with equipment for 5-year-old preschool children in Hanoi City, including 35 exercises of 8 groups oriented to physical development of 5-year-old children: (1) Group of movement exercises; (2) Group of stretching exercises; (3) Group of exercises that stimulate height growth; (4) Group of orientation exercises; (5) Group of exercises for upper limb development; (6) Group of exercises for lower limb development; (7) Group of skillful development exercises; (8) Group of mixed exercises.
Pluronic F-127 Hydrogel for Delivering Antimicrobial Agents: A Bibliometric Analysis using Scopus Database
Authors: Sharun Khan , Banu S. Amitha , Nair Sonu S. , Kumar Rohit , Pawde A.M. , Dhama Kuldeep , Pal Amar
Published: July 2023

Infectious diseases caused by pathogenic microorganisms pose significant threats to public health globally. The emergence of antibiotic-resistant bacteria has further complicated the treatment of these infections, necessitating the exploration of alternative therapeutic strategies. Among these strategies, the use of hydrogels as delivery systems for delivering antimicrobial agents has gained considerable attention. This paper presents a comprehensive bibliometric analysis of the utilization of Pluronic F-127 (PF-127) hydrogel for delivering antimicrobial agents. The aim of this study is to explore the current research landscape, identify key trends, influential authors, and prominent journals in this field. The analysis is based on a systematic search conducted using the Scopus database. The analysis covered publication trends, geographic distribution, influential authors, and key journals in the field of PF-127 hydrogel-based antimicrobial agent delivery. The results revealed the growing interest in this field, with a focus on countries such as India, the United States, and Egypt. The analysis also identified top authors, institutions, and journals contributing to the research. The findings reveal the growth of research in this area, highlighting the potential of PF-127 hydrogel as a promising vehicle for antimicrobial agent delivery. It highlights the need for further research to optimize formulation parameters, explore combination therapies, conduct in vivo studies, and promote collaboration to maximize the therapeutic potential of PF-127 hydrogel-based delivery systems in combating infectious diseases and antimicrobial resistance. This paper provides valuable insights into the existing literature and serves as a reference for future research and development in the field.
PENDAMPINGAN DAN PELATIHAN PENYUSUNAN LAPORAN KEUANGAN PADA SD MUHAMMADIYAH 8 DAN SMP MUHAMMADIYAH 2 KOTA MALANG
Authors: Widyastuti Aviani , Gina Harventy  , Djoko Sigit Sayogo
Published: July 2023

Until now, many schools do not understand how to prepare good and quality financial reports so that they can convey information properly to stakeholders. Lack of understanding due to the competency background possessed can also cause the resulting financial reports to also vary. This can be seen in SD Muhammadiyah 8 and SMP Muhammadiyah Malang City which have different financial reporting systems. On the other hand, as a subsidiary entity under the auspices of PDM Malang City, SD Muhammadiyah 8 and SMP Muhammadiyah 2 Malang City must report their financial reports to PDM so that consolidation can be carried out. This diversity of reporting systems also eventually led to problems for PDM Malang City. Based on this, to improve understanding and ability to produce uniform financial reports, it is necessary to carry out training and assistance on an excel-based financial reporting system as an approach method in solving existing problems.
Pelatihan Arduino kepada Remaja Mushola Ka’bah dengan Tema: “Santri Berdikari, Mandiri Teknologi”
Authors: Ikhwan Taufik  , Hilmy Fuad
Published: July 2023

Al Iman is a prayer room with a unique shape like the Kaaba and have an ancient handwritten Al Qur'an by Syech Al Basyin in ancient times. Even though there are these privilege, it turns out that the time markers in the Al Iman prayer room are only limited to wall clocks. The problem is, Al Iman is relatively small, has just been built, and haven't enough cash to allocate to procuring digital prayer time markers (focus on completing construction). Meanwhile, local youth have a high learning spirit and the surrounding community looks very enthusiastic. This is proven by the existence of the Mushola Youth Association and the routine "reciting Al Qur'an" which is carried out every night after praying together. Therefore, the solution offered is the holding of learning activities or "ngaji" (training). However, "ngaji" in this time is about of technology especially the basics of microcontroller programming. Hope can add insight into digital technology and microcontroller programming, especially Arduino Uno as a basis for making microcontroller-based digital clocks. Furthermore, an understanding of digital technology and microcontroller programming which is applied in the form of digital clocks marking prayer times is displayed and used in the Mushola.
Pendampingan Kurikulum Akuntansi Desa di SMK Muhammadiyah 02 Kota Malang
Authors: Affan Muhammad Wildan
Published: July 2023

Kurikulum akuntansi desa sangat diperlukan di jurusan akuntansi di SMK yang ada di Indonesia, maka dari itu kami mengadakan pendampingan kurikulum akuntansi desa di jurusan akuntansi SMK Muhammadiyah 02 Kota Malang. Pendampingan kurikulum ini dikemas dengan model sosialisasi materi mengenai akuntansi desa dan pembuatan modul akuntansi desa yang nantinya bisa bermanfaat untuk SMK Muhammadiyah 02 Kota Malang. Dari hasil yang telah diperoleh peserta dapat memahami bagaimana akuntansi desa dan apa saja yang ada didalam akutansi desa itu sendiri seperti laporan keuangan, laporan kegiatan dan lainnya..
PELATIHAN PEMBUATAN VIRGIN COCONUT OIL (VCO) UNTUK MENINGKATKAN NILAI JUAL PRODUK OLAHAN KELAPA DI DESA CURUG GOONG, KABUPATEN SERANG, BANTEN
Authors: Ruspita Roza , Agipa Ade Irmadiki
Published: July 2023

Training on making Virgin Coconut Oil (VCO) has been held in Curug Goong Village, Serang Regency, Banten. VCO is pure coconut oil which has many benefits with a relatively easy manufacturing process. Curug Goong Village has potential as a producer of coconuts but has not been used optimally, so this activity aims to train the community to be able to process coconuts into products with a higher selling value. The training on making VCO was attended by 30 participants consisting of coconut farmers and housewives. This training was carried out in 3 stages of activity, these are: the preparation, the implementation and the evaluation stage. This training received a positive response from the people of Curug Goong Village. The evaluation results show 31 participants took part in socialization and training, 26 participants filled out questionnaires. After the training, the people of Curug Goong Village became more familiar with VCO, could differentiate between ordinary coconut oil and VCO, and could practice it at home.­
Analysis of methods for calculating the stability of cellular structures
Authors: Terikhov Egor M. , Anshakov Aleksandr S.
Published: July 2023

Introduction. Cellular structures are widely used in world practice to solve various problems. By means of such structures mooring and barrier constructions, and also the cofferdams are erected which allow to drain territory below a water level for the subsequent construction of the main structures on dry land. In domestic practice, these structures are often made of sheet piling profiles with high moment of inertia and moment of resistance as a part of anchored or interanchored thin walls. This design solution requires heavy-duty sheet piling sections and heavy anchoring devices at considerable water depths, which increases the steel intensity of the structure. For temporary structures the material and labor-intensive nature of the structure is undesirable. The honeycomb construction consists of flat sheet piles with cavities filled with soil. Materials and methods. Various stability tests of the cellular structure variant have been carried out in accordance with the current regulatory documents; recommendations for the design of these structures by the European company ArcelorMittal, which has extensive experience in designing realized projects of structures using this technical solution, have also been used. The stability indicator results are compared with the results of finite-element model calculations performed in the MIDAS FEA NX calculation complex. Results. Based on the calculation of a three-dimensional model of a cellular structure, a comparison was made with analytical methods for calculating stability. The analytical calculation of stability according to the deep shear scheme in accordance with current regulations has both a close convergence of the stability coefficient and a potential buckling surface in comparison with the FEM problem in a three-dimensional formulation. Conclusions. The main limiting factor in calculations of stability of cellular structures is the stability coefficient according to the scheme of deep shear.
Reducing heat gain in buildings by artificially lowering the outside air temperature through evaporative cooling
Authors: Egnatosyan Siranush M. , Egnatosyan Naira M. , Yeritsyan Lusine A.
Published: July 2023

Introduction. Systems for microclimate regulation in buildings consume a large amount of natural energy resources. Statistics show that 40 % of energy is used for heating, ventilation and air conditioning. This problem is directly related to the heating and cooling load of the building, i.e. it depends on the thermal engineering characteristics of building envelopes and the thermal protection of the building.

Materials and methods. To reduce the consumption of energy resources, the most common method is the thermal insulation of enclosing structures, increasing the thermal resistance of enclosing structures, which is a complicated thermal engineering problem. An alternative new method of reducing heat gain into buildings through evaporative cooling of outside air which leads to reduction of cooling load of building and subsequently influences the reduction of greenhouse gas emissions is considered. For this purpose, a spray irrigation system is installed on the southern wall of the building to lower the conditional boundary layer temperature which is formed as a result of solar radiation.

Results. The suggested method passively reduces the boundary layer temperature, which tends to the temperature of the wet-bulb thermometer, as a result, the heat influx into the building is reduced, which leads to a lower cooling load and increases the energy efficiency of the system.

Conclusions. Green architecture and zero-energy building design are relevant and important at the present time. World statistics show that 14 % of all potable water is used in buildings, in order to use potable water economically the proposed system installs a rainwater accumulation tank for outdoor irrigation. A comparative analysis showed that by cooling evaporation and artificially lowering the outside air temperature, the cooling load of the building is reduced by 20 %, which results in a reduction of greenhouse gas emissions.
educação politécnica e a formação política dos jovens
Authors: Soares Priscila da Silva , Avilar Wilkerson Oliveira de , Pasqualli Roberta
Published: July 2023

A preocupação central desse ensaio volta-se para a discussão acerca da educação politécnica e as suas contribuições na formação política dos jovens, visto que algumas escolas estão mais atentas às métricas das avaliações diagnósticas do Ministério da Educação (MEC) do que em formar para o exercício da cidadania e preparar para o mundo do trabalho. Foi constituído numa abordagem qualitativa e dialética, produzido por meio de pesquisa bibliográfica e análise documental. Como repercussões assume-se que a politecnia contribui com o desenvolvimento do senso de importância da participação política nos jovens, tendo em vista que se espera que o sujeito formado em seus aspectos culturais, científicos, técnicos e tecnológico, ou seja, na categoria da totalidade, seja mais crítico e reflexivo.
Alinhando os tijolos
Authors: Silva Emanuelly Wouters , Costa Jaqueline do Espírito Santo
Published: July 2023

O presente trabalho tem como tema a construção da identidade profissional do professor, tendo como objetivo investigar o conceito, as características da identidade profissional do professor e os aspectos que influenciam em sua construção. Para isso foi realizada uma pesquisa bibliográfica, na qual foram elencadas as principais concepções dos autores pesquisados, definidos conceitos-chave e desenvolvidas reflexões nessa premissa. Os autores para este estudo foram selecionados com vistas a alcançar os objetivos elencados. Os resultados apontaram a identidade como uma construção constante, tendo início antes da formação inicial, percorrendo a formação inicial, a prática (e as reflexões sobre a prática), juntamente com as formações continuadas. Além disso, concluiu-se que não existe professor “ideal” e nem modelo único de identidade. Desta forma, a identidade profissional docente se transforma ao longo de sua formação e não ficar estagnada, mas se adequa ao meio.
Música brasileira de raiz cristã
Authors: Brito Deivison , Vargas Herom
Published: July 2023

O artigo busca compreender alternativas no cancioneiro evangélico brasileiro no trabalho artistas que não se identificam com rótulo hegemônico gospel. Termos como “música feita por cristãos” e “música brasileira tecida na esperança” são mobilizados para canções que tratam da vida cotidiana. Busca-se refletir sobre a produção de sentido da canção dos artistas: Marcos Almeida, Estêvão Queiroga e Gerson Borges. A análise da obra dos compositores visa aprofundar a discussão sobre a música evangélica brasileira e fomentar outras formas de compreensão da canção por meio dos usos e apropriações culturais. Os procedimentos metodológicos incluem: análise semiótica (LOTMAN) e a noção de gênero musical (FABBRI) por meio das categorias chamadas anafonias e musemas (TAGG).
Hollow sp2-conjugated covalent organic framework encapsulating thiophene-based photosensitizer for enhanced visible-light-driven hydrogen evolution
Authors: Yang Chen , Hu Huawei , Qian Cheng , Liao Yaozu
Published: July 2023

Vinylene-linked covalent organic frameworks (COFs) have gained
increasing attention for photocatalytic hydrogen evolution. However, the
photocatalytic activity of vinylene-linked COFs has been restricted due
to low exciton dissociation efficiency and wide band gap. Herein, we
fabricated a novel p-n type Z-scheme heterostructure, g2T-T@HCOFs,
through the hybridization of vinylene-linked COFs with a hollow
structure and thiophene-based photosensitizer (g2T-T) using a template
method and post-encapsulating modification. The hollow-structured HCOFs
enable uniform encapsulation of the g2T-T both within their channels and
on their surfaces, which facilitates the formation of a firm and stable
interface between n-type HCOF and p-type g2T-T. Therefore, the
encapsulation of g2T-T enables the realization of a Z-scheme pathway for
efficient charge separation and transfer, leading to enhanced electron
accumulation within the HCOFs during water splitting. Consequently, the
obtained p-n type Z-scheme heterostructure g2T-T@HCOFs exhibit a
remarkable 5.5-fold enhancement in visi-ble-light-induced hydrogen
evolution activity compared to the pristine COF.
Reinforcement learning-based composite suboptimal control for Markov jump singularly perturbed systems with unknown dynamics
Authors: Wu Jiacheng , Li Wenqian , Wang Yun , Shen Hao
Published: July 2023

In this article, a model-free parallel reinforcement learning method is
proposed to solve the suboptimal control problem for the Markov jump
singularly perturbed systems. First, since fast and slow dynamics
coexist in Markov jump singularly perturbed systems, it may lead to
ill-conditioned numerical problems during the controller design process.
Therefore, the original system can be decomposed into independent
subsystems at different time-scales by employing the reduced order
method. Besides, a model-based parallel algorithm is designed to obtain
the optimal controllers of the fast and slow subsystems respectively.
Moreover, within the framework of reinforcement learning, the composite
controller of the Markov jump singularly perturbed systems can be
obtained without system dynamics. Finally, a numerical example is
introduced to prove the effectiveness of proposed algorithms.
Host-pathogen interactions under pressure: a review and meta-analysis of stress-mediated effects on disease dynamics
Authors: Vicente-Santos Amanda , Willink Beatriz , Nowak Kacy , Civitello David , Gillespie Thomas
Published: July 2023

Human activities have increased the intensity and frequency of natural
stressors and created novel stressors, altering host-pathogen
interactions, and changing the risk of emerging infectious diseases.
Despite the ubiquity of such anthropogenic impacts, predicting the
directionality of outcomes has proven challenging. Here, we conduct a
review and meta-analysis to determine the primary mechanisms through
which stressors affect host-pathogen interactions and to evaluate the
impacts stress has on host fitness (survival and fecundity) and pathogen
infectivity (prevalence and intensity). We assessed 891 effect sizes
from 71 host species (representing seven taxonomic groups) and 78
parasite taxa from 98 studies. We found that infected and uninfected
hosts had similar sensitivity to stressors and that responses varied
according to stressor type. Specifically, limited resources compromised
host fecundity and decreased pathogen intensity, while abiotic
environmental stressors (e.g., temperature and salinity) decreased host
survivorship and increased pathogen intensity, and pollution increased
mortality but decreased pathogen prevalence. We then used our
meta-analysis results to develop Susceptible-Infected theoretical models
to illustrate scenarios where infection rates are expected to increase
or decrease in response to resource limitation or environmental stress
gradients. Our results carry implications for conservation and disease
emergence and reveal areas for future work.
Toxicidad muco-cutánea: un desafío en el tratamiento oncológico
Authors: Gutiérrez-Pastor Iván
Published: July 2023

El tratamiento combinado con inhibidores de tirosina quinasa e inmunoterapia en el cáncer de pulmón avanzado con mutación del EGFR es un enfoque emergente en la investigación clínica. Algunos estudios preliminares han mostrado resultados prometedores, con mejorías en la respuesta tumoral y la supervivencia global en comparación con la monoterapia. Sin embargo, esta combinación puede aumentar el riesgo de eventos adversos, por lo que se requiere un seguimiento estrecho y una atención médica especializada. Se presenta el caso de un varón de 57 años con adenocarcinoma de pulmón que manifestó exantema generalizado grado 3 con lesiones pápulo-pustulosas, paroniquia y tricomegalia secundario al tratamiento con lazertinib-amivantamab. Además, el paciente desarrolló una proctalgia crónica con mal control álgico debido a la aparición de úlceras anales e hipertonía del esfínter anal.