bluuebunny/crossref_metadata_2025 huggingface dataset:
Праміпексол пролонгованого вивільнення — нові можливості тривалої дофамінергічної стимуляції при хворобі Паркінсона
Authors: Karaban I.M.
Published: June 2021

Найважливішим підходом до дофамінергічної стимуляції при хворобі Паркінсона (ХП) є застосування агоністів дофамінових рецепторів (АДР). Порівняно з препаратами леводопи АДР характеризуються меншим ризиком розвитку лікарських дискінезій і моторних флуктуацій, відсутністю необхідності метаболізації в головному мозку й встановленим в експерименті нейропротективним потенціалом. Одним з найбільш ефективних препаратів цієї групи є праміпексол — синтетичне похідне бензотіазолу (тетрагідробензотіазол). Праміпексол є потужним агоністом D2-рецепторів з максимальною спорідненістю до підтипу D3-рецепторів. Стимуляція D2-рецепторів базальних гангліїв забезпечує ефект препарату щодо рухових проявів захворювання, у той час як стимуляція D3-рецепторів лімбічної системи зменшує немотор-ні прояви, у тому числі позитивно впливає на нейропсихологічний статус і зменшує ступінь вираженості депресивного синдрому у хворих із ХП. Ефективність праміпексолу доведена численними дослідженнями як на ранніх стадіях ХП — як монотерапії, так і на розгорнутих стадіях — у поєднанні з препаратами леводопи. Із розвитком захворювання схема його лікування ускладнюється за рахунок збільшення кількості прийнятих препаратів і кратності їх прийому. Це неминуче створює проблему недостатньої прихильності пацієнтів до лікування. У зв’язку з цим розроблена нова лікарська форма праміпексолу — праміпексол пролонгованої дії, що забезпечує його тривале вивільнення й допускає одноразовий прийом протягом дня. Це не тільки робить лікування хворого більш зручним, але й покращує прихильність пацієнтів до лікування, підвищує довгострокову ефективність терапії. Крім того, при повільному вивільненні праміпексолу протягом доби досягається більш стабільна його концентрація в крові, що може забезпечити кращу переносимість і ефективний контроль симптомів захворювання протягом усього дня (як у денний, так і в нічний час).
Smart Solar Irrigation System
Authors: Tripathi Naman
Published: June 2021

This paper deals with the one of the various innovative ways to irrigate a field or water the plants using solar power. Irrigation is needed in the fields or farms where is less availability of water , since agriculture plays one of the most vital role in increasing or decreasing our country’s economy . An improvising system is needed in order to ensure not even healthy growth of the plant’s but also reduction of the amount of water wasted during such activities. So, this project signifies a Smart solar irrigation system using Arduino, this project helps in opening and closing the water supply according to the moisture level in the soil and the moisture level in soil is calculated by the help of soil moisture sensor which is one of the most important component in this project. The smart solar irrigation system will have zero electricity cost as whole project runs on solar energy beside that it is a farmer-friendly project helps in reduction of cost of the men required in the field to irrigate and most importantly reduces the amount of water wasted in irrigation of the fields.
Nutritional Values of Fruit through Image Processing
Authors: Dongre Prof. Shital P.
Published: June 2021

Health is the most important aspect of any human being. With the increasing pace of life, the focus on health was decreasing. This has created a wide number of problems like obesity, diabetes, hypertension, etc. Fruits contain a major source of energy, vitamin, nutrients which should be the vital part of diet. This paper presents a nutrition measurement system which calculates the precise quantity of moisture, protein, fiber, carbohydrates and fats present in the fruit. The system works without any complex hardware and weighing scale. It calculates the precise mass of fruit using two images digital images of the same fruit.
A Review on Advanced Home Automation System using GSM and AI
Authors: Gulkari Shruti S.
Published: June 2021

In this proposed work, we are going to connect home appliances to user mobile so that they can handle their appliances by remote distances. Smart home and artificial technology are the trending technology which is developing rapidly. This smart home product improves the quality of living for occupants. In this system, we explore full home control or home automation by using GSM (Global System for Mobile Communication). User home appliances such as LED bulb, air conditioner etc. is controlled by GSM (Global System for Mobile Communication) modem via SMS (Short Message Services) text message is presented in this paper. In this project, we are using AI (Artificial Intelligence) to operate devices. AI (Artificial Intelligence) is relatively a new idea that is easily accessible today by anyone who has access to a computer or a smartphone. This (Artificial Intelligence) also becoming a powerful presence in technology, has been swiftly dominating the home automation market. This allows us to integrate smart solutions into our everyday tasks. In this work, we are going to execute a continuous process to home appliances control system without any supervisor and later it will co-ordinate appliances and other devices through Short Message Service using GSM(Global System for Mobile Communication) and AI(Artificial Intelligence)
Soil Monitoring and Testing using IoT for Fertility Level and Crop Prediction
Authors: Raut Swapnil Sunil
Published: June 2021

Agribusiness is the foundation of India. In India, 50 % of the remaining task at hand depends upon agribusiness. The responsibility of the agriculture part in the Indian economy is higher than some other divisions in India. In any case, Farmers utilized customary strategy for developing harvests, which involve less profitability of yields. Additionally, an erosion and disintegration are likewise a principle motivation to less profitability of yields. This will impact in diminishes fruitfulness level. Loss of soil supplements through different courses is likewise motivation to diminish soil richness level. Supplements like potassium (K), nitrogen (N), and phosphorus (P) are basic for the evolution of a plant. The advancement in agriculture is vital to tackle these issues in the agribusiness part and shrewd cultivating is that the appropriate response. This can be conceivable utilizing IOT gadgets. Farmers can get the necessary data just as the screen is yield. IOT associates the whole world with the help of sensors and other installed gadgets. The diverse soil tests will be taken from various fields and soil esteems will be determined to utilize a PH sensor where supplements worth will be separated from it. The live information will be sent to the cloud database where information will be put away. Where information will be broke down to improve crop yields. Here for information broke down information mining method is used. Information mining in agriculture assumes an imperative job in yield assumptions, soil productivity, and plant sicknesses and so on. Farmers can watch information on screen by a website. What's more, farmers will likewise get crop lists dependent on that information which harvests will be possible to yield in that soil.
A Comparative Study of Erythrocyte Sedimentation Rate using Saline Diluted and Undiluted EDTA with TSC
Authors: Raphel Sruthy
Published: June 2021

Erythrocyte sedimentation rate (ESR) is the rate at which RBC sediment in a period of 1 hr. It is a common Haematology test that is a non-specific measure of inflammation and it became a common screening test worldwide for acute phase proteins and chronic diseases. The International Council for Standardization in Haematology (ICSH) recommended the Westergren method as the method of choice for ESR determination. TSC is almost exclusively used as the diluent of choice for setting up ESR, but some contemporary laboratories have resolved to use Normal saline (NS) as the diluent of choice while other set ESR using EDTA anticoagulated Blood (BLD) without any diluent. The objective of this study is to assess the comparison between saline diluted and undiluted EDTA with TSC as an anticoagulant in ESR detection and to find out any gender wise variations by using these anticoagulants. A total of 50 students were participated in this study. From each of the participants 5 ml of BLD was collected and it is then divided into 3 parts. 1.6 ml BLD to 0.4ml 3.8% TSC tube, 1.6 ml EDTA blood to 0.4 ml NS tube. 3rd tube with 2 ml EDTA BLD and set for ESR and obtained result within 1 hour. The Result is the mean +SD value of ESR were 19.48+5.7 mm/hr. in undiluted EDTA, 15.22+4.6 mm/hr. in saline diluted EDTA & 15.36+4.5 mm/hr. in TSC. The mean difference of ESR value between saline diluted EDTA with TSC BLD was 0 and it with undiluted EDTA was 4 mm /hr. The study indicates that there was a significant difference between ESR value with undiluted EDTA and TSC while diluted EDTA and TSC were there is no significant difference. The mean +SD of ESR value using undiluted, diluted EDTA and TSC in males were 16.20+3.3, 11.05+2.8, 11.29+2.6 and while it for females were 21.69+5.2, 17.36+3.8, 17.45+3.8 respectively. In conclusion, TSC is the best diluent to be used in contemporary lab to set ESR as compared to EDTA BLD. But we can use saline diluted EDTA as an alternative to citrate diluted BLD to set ESR and it also showed there is a gender wise variation in ESR using these anticoagulants.
Smartphone based ECG Acquisition and Analysis
Authors: Kapse Renuka Vijay
Published: June 2021

Health monitoring and technologies related to health monitoring is an appealing area of research. The electrocardiogram (ECG) has constantly being mainstream estimation plan to evaluate and analyse cardiovascular diseases. Heart health is important for everyone. Heart needs to be monitored regularly and early warning can prevent the permanent heart damage. Also heart diseases are the leading cause of death worldwide. Hence the work presents a design of a mini wearable ECG system and it’s interfacing with the Android application. This framework is created to show and analyze the ECG signal got from the ECG wearable system. The ECG signals will be shipped off an android application via Bluetooth device. This system will automatically alert the user through SMS.
Eye Tracking System using Matlab
Authors: Snehitha Kanaparthi
Published: June 2021

There are many people around us who suffer from diseases like paralysis, quadriplegia due to which they cannot move their hands and legs. People suffering from such diseases need a person to be with them all the time to understand their needs and assist them. So, for their aid we want to implement an EYE DIRECTIVE WHEEL CHAIR, which moves in the direction based on the movement of eye balls of the person, helping in mobility. For this project we are designing a system called EYE TRACKING SYSTEM. This system consists of a camera, which is mounted on the wheel chair, which captures the movement of the eye balls of the person continuously. And these images are processed by a simulation software called MATLAB. This directs the motion of the EYE DIRECTIVE WHEEL CHAIR. When the person looks in a direction, the angle of rotation of the eyeball is calculated using MATLAB by processing the images continuously captured by the camera. When the person moves his eye balls in left direction, it shows to move left. Similarly, if he moves his eye balls in right direction, it shows move right. It shows move forward when eye balls or looking straight. And in every other situation it shows stop.
Design and Analysis of Radiant Ceiling Cooling Panels for Classroom
Authors: Mohite Ms. Amruta
Published: June 2021

In this study, radiant cooling panel is designed for a classroom. An arrangement is made such that the panels cover 70% of ceiling area. For study case a classroom is considered which need 27 such panels for covering 70% of area. The arrangement of panels, water flow rate, required temperature and amount of heat transfer taking place through panels is discussed in the paper. A cooling system is selected for maintaining the desired water temperature. Comparison is done between the cooling systems and the user can use any of them according to the requirements and cost. This system does not use any refrigerant hence it is environment friendly and can add a considerable solution to maintain temperature of a specific area. CFD analysis of the panel shows that adequate heat transfer takes place between panel and the room, this validates the design. When 15 ºC water is given as inlet to the panel, we get 22 ºC water as output at outlet of panel. In this paper, analysis is done for single panel same can be done for entire arrangement of panel structure.
Scrolling Text Display on 8x8 LED Dot Matrix using NodeMCU
Authors: Teja Pogula Sai
Published: June 2021

Generally we use simple led regular static type display screen to deliver the message. Previously, to update the data either it may be large one it takes a long process to update data. Now a days scrolling type displays are more preferred over the static type displays. By adopting a programming device called NODEMCU, data can be displayed on dot matrix in scrolling manner. By adopting led 8x8 dot matrix using can controlled via IoT based system which controlled by mobile or laptop. Scrolling type text display boards, projects uses led dot matrix displays or regular outside purpose digital sign boards. The message scrolling displays are also type of scrolling LED display examples, presented here are nodemcu based led matrix display project. The led matrix is controlled using nodemcu by serial communication protocols. In this pair of 8*8 led Matrix display modules have used to display the transmitted message on Matrix display. nodemcu is heart of this project. The nodemcu is the transmitter to send data, and the receiver is led matrix display to display message on it.
Tracking User Interaction with Web and Assisting in Targeted Communication
Authors: Ahuja Dheeraj
Published: June 2021

Today, we spend most of our time online using some form of digital technology (such as search engines, news portals, or social media sites). Our online presence keeps us involved most of the time and provides a lot of information to Internet customers. The development of the web is excellent because every day about a million pages are added. Due to the massive use of the network, the log files of the network increase at a faster rate and the scope becomes enormous. Web Usage Mining uses mining technology on log data to extract user performance, which is used in different applications such as support design, e-commerce, service modification, prefetch, etc. In this paper, we propose a tool that users can use to collect data on their website, and then use this web log data to track user interactions on your website, which helps in targeted communication.
Computational Investigation of through the Width Delamination of a Composite Laminate using Surface based Cohesive Contact Behaviour
Authors: Vishwanath K. S.
Published: June 2021

The fiber reinforced polymer laminates have found extensive applications because of its advantages over other materials in terms of strength to weight ratio, manufacturing flexibility and so on. But in the transverse direction, strength is comparatively less so that a failure mechanism called delamination will occur in case of poor manufacturing or when tools are dropped. In this paper, Surface based Cohesive contact behavior is implemented at the interface between base and sub laminate to investigate for 60mm through the width buckling driven delamination growth. The computational prediction of delamination growth initiation is obtained by solving a HTA/6376C composite laminate specimen for geometric non linearity using SC8R continuum shell elements of Abaqus CAE and by plotting the inplane loads versus out of plane displacements.
Experimental Investigation on Double Skin Composite Tubular Column
Authors: Rajkumar K. C.
Published: June 2021

RCC and steel frames have been the most common frame systems for long times whereas composite frame system has also emerged as popular system for high rise buildings for few decades. Multi-storey composite frames are generally composed of structural steel members made composite with concrete. The use of Double-Skin Tubular columns in building construction has seen renaissance in recent years due to their numerous advantages, apart from its superior structural performance making a typical composite frame structure. Fiber reinforced polymers (FRPs), a relatively new class of non-corrosive, high-strength, lightweight material, have over the past approximately 15 years emerged as practical materials for a number of structural engineering applications. FRP has become one of the most popular methods in the repair and rehabilitation of concrete infrastructure due to its ease of application and the special physical characteristics. This paper focus to determine the compressive strength of columns in different type of specimens under Axial load.
Human Animal Conflict in State of Maharashtra using Data Analytics
Authors: Gandhe Arnav
Published: June 2021

Maharashtra, a land rich in its biodiversity, well known for its wildlife. Maharashtra stands 3rd in terms of Human-Animal Conflict behind Uttarakhand and Karnataka. Human–Animal conflict refers to the interaction between wildlife and people leading to a resultant negative impact on people, their resources, wild animals and their habitat. The paper discusses a 2year study(1st Jan-2019 to 1st Jan 2021) carried out on human-animal interactions in Maharashtra -focusing on various factors involved under Human-animal conflict, and its current situations in the state. The Paper further focuses on use of advanced computer technologies, and techniques like Data Analytics & Statistical Analysis to study the actual current situation of Human-Animal Conflict in Maharashtra.
Reseña: En defensa del populismo
Authors:   Universidad Nacional Autónoma de México, Sepúlveda Murillo Erick Israel
Published: June 2021

Carlos Fernández Liria es Doctor en Filosofía por la Universidad Complutense de Madrid y profesor en la Facultad de Filosofía en esa misma universidad, también se ha desempeñado como guionista de televisión y ha estado vinculado al partido político Podemos desde su creación, actualmente es parte de la plataforma Más Madrid encabezada por Iñigo Errejón (cofundador de Podemos). Su libro, En defensa del populismo, debe ser leído desde el contexto de la irrupción de Podemos en el escenario político español con todas las consecuencias y discusiones que ello ha acarreado. Por eso a menudo se alude a todo el vocabulario de este debate político que ha tenido lugar en España en los últimos años.
De la experiencia a la confusión. Masculinidades, afectos y emociones en los relatos de varones que pagan por sexo en Argentina
Authors:   Universidad de Buenos Aires, Morcillo Santiago
Published: June 2021

Este artículo aborda diferentes narrativas que aparecen en los relatos de varones que pagan por sexo haciendo foco en las tensiones emocionales y afectivas que representan para sus masculinidades. Se busca complejizar algunos estereotipos sobre los varones que pagan por sexo y comprender las especificidades del mercado sexual para pensar las relaciones de poder en la articulación entre masculinidad, emociones y afectos. Este análisis es fruto de una etnografía virtual en dos foros online de experiencias de comercio sexual, en el marco de un trabajo de campo con distintos actores en el mercado sexual argentino. Se describen tanto los relatos más modelizados, aparentemente despojados de emociones, como aquellos, aparentemente excepcionales, donde emergen afectos y confusiones que desestabilizan ciertas formas de masculinidades. En la lectura final de estos relatos emergen los puntos de conexión entre ambos permitiendo poner de relieve las ilusiones que la lógica del mercado sexual produce.
Reseña: Pandemia. La covid-19 estremece al mundo
Authors:   Universidad Autónoma de Baja California Sur, Almada Alatorre Rossana A.
Published: June 2021

La versión digital de este libro sale a la luz en mayo de 2020 con 82 páginas. En él, Slajov Zizek aborda, en once capítulos y un apéndice, el tema de la pandemia que azota al mundo entero; su reflexión resulta temprana, si se me permite, pues eso le obliga a referirse principalmente al problema en Europa, tocando someramente la situación de los Estados Unidos, mientras en América Latina el virus prácticamente venía aterrizando en algunos lugares y aún no vislumbrábamos de manera más o menos clara la magnitud del problema que enfrentamos
Editorial
Authors: Berté Rodrigo , De Cássio da Silva Rodrigo
Published: June 2021

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AS MEDIDAS CAUTELARES ALTERNATIVAS À PRISÃO: O PROJETO DE REFORMA DO CÓDIGO DE PROCESSO PENAL BRASILEIRO E A REALIDADE LATINO-AMERICANA
ALTERNATIVE PRECAUTIONARY MEASURES TO IMPRISONMENT: THE RENOVATION PROJECT OF THE BRAZILIAN CODE OF CRIMINAL PROCEDURE AND THE LATIN AMERICAN REALITY
Authors: Giacomolli (PUC/RS) Nereu José , Maya (PUC/RS) André Machado
Published: June 2021

A Lei 12.403/2011 rompeu com a dicotomia prisão ou liberdade durante a tramitação do processo penal, introduzindo medidas cautelares alternativas ao recolhimento ao cárcere. A prisão cautelar preventiva foi relegada, pelo legislador e pela doutrina mais adequada ao constitucionalismo e ao convencionalismo internacional, como de ultima ratio. Essas medidas alternativas não afastam a exigência de cautelaridade e a satisfação dos requisitos e reservas legais e constitucionais, por implicarem restrições ao processado. Tramita na Câmara dos Deputados, projeto já aprovado pelo Senado da República, o qual tipifica quatorze medidas cautelares diversas do recolhimento ao cárcere. As reformas processuais penais de grande parte dos países da América Latina também concentraram uma importante discussão nas cautelares pessoais alternativas ao recolhimento à prisão.
HEDIONDEZ E REINCIDÊNCIA: UMA ANÁLISE DO REQUISITO OBJETIVO NECESSÁRIO PARA A PROGRESSÃO DE REGIME À LUZ DA POLÍTICA CRIMINAL DO CÁRCERE
HEINOUS CRIME AND RECURRENCE: AN ANALYSIS OF THE OBJECTIVE REQUIREMENT NECESSARY FOR THE PROGRESSION OF REGIME IN THE LIGHT OF THE CRIMINAL POLICY OF INCARCERATION
Authors: Aleixo (PUC Minas) Klelia Canabrava , Penido (PUC Minas) Flávia Ávila
Published: June 2021

O presente artigo visa abordar a divergência quanto ao requisito objetivo necessário à concessão da progressão de regime na hipótese de condenados por crimes hediondos ou equiparados. Tal divergência surge em razão da lei não especificar se a fração de 3/5 (três quintos), mais gravosa, aplica-se a reincidentes em crimes hediondos ou equiparados ou a qualquer reincidente, ainda que o crime anterior não seja dessa natureza. Diante desta cisão, pesquisou-se os fundamentos da alteração legislativa, que culminaram no aumento do requisito objetivo, de forma a buscar uma interpretação condizente com o paradigma do Estado de Direito Democrático. Portanto, trata-se de um artigo construído a partir de pesquisas bibliográficas e que se pautou em uma metodologia analítica crítica.  Percebeu-se que, em face da carência de teor significante da norma, se firmou o entendimento jurisprudencial que exige a fração de 3/5 (três quintos) do cumprimento da pena pelo condenado reincidente, ainda que o crime anterior não seja hediondo ou equiparado, como requisito objetivo para a concessão da progressão de regime. A extensão do alcance da lei a reincidentes, cujo crime anterior não seja hediondo ou equiparado, fere o princípio da especialidade. A abertura, dada ao intérprete-juiz por texto de lei carente de significação, permitiu, pois, que sua interpretação fosse feita como mecanismo de implementação de políticas repressivas, encarceradoras, de segregação do indesejável conforme a biopolítica vigente.
AGROINDÚSTRIAS FAMILIARES RURAIS: UM ESTUDO DOS EMPREENDIMENTOS DO MUNICÍPIO DE CONSTANTINA-RS
Authors: Conteratto Caroline , Matte Alessandra , Spanevello Rosani Marisa , Andreatta Tanice
Published: June 2021

O objetivo desta pesquisa é identificar as percepções de agricultores acerca das atividades envolvendo agroindústrias rurais familiares do município de Constantina, situado na mesorregião Noroeste do estado do Rio Grande do Sul. Por meio do estudo de múltiplos casos, analisaram-se 21 empreendimentos. Os empreendimentos são de pequeno porte, a mão de obra é familiar, e a inserção nos mercados ocorre majoritariamente por meio de feiras livres, dos supermercados e da venda direta em domicílios. Como fatores dinamizadores destes mercados, os entrevistados elencaram a qualidade dos produtos, as relações de confiança e a possibilidade do conhecimento da origem e do processo de produção.
A INFLUÊNCIA DAS LÓGICAS INSTITUCIONAIS NA ORGANIZAÇÃO ECONÔMICA DA AGRICULTURA FAMILIAR: UMA ANÁLISE NO SEMIÁRIDO NORDESTINO
Authors: SILVA CAMILA MARQUES VIANA , SCHULTZ GLAUCO
Published: June 2021

Este trabalho pretende contribuir para a compreensão da relação entre a agricultura familiar e os mercados, através da mediação por organizações econômicas, objetivando fornecer, de maneira mais ampla, elementos para análise do papel que os arranjos organizacionais mobilizados pelos agricultores familiares exercem no desenvolvimento rural. Com base na premissa de que ao expandir suas relações e moldar seu campo organizacional a partir da rede de relações que estabelecem para acessar mercados, as Organizações Econômicas da Agricultura Familiar - OEAF são afetadas por uma ou mais lógicas institucionais presentes no ambiente no qual interagem, através da adoção de práticas materiais e simbólicas. Entender, portanto, como essas organizações sobrevivem diante da fragilidade de sua inserção econômica implica em conhecer quais lógicas as influenciam. Considerando a agricultura familiar como campo societal, foi identificada influência de dois tipos puros de lógica do sistema interinstitucional, a lógica do estado, a lógica da comunidade, uma variante da lógica de mercado, identificada como lógica do mercado alternativo e, por fim, uma lógica híbrida, a partir da combinação da lógica do estado e da lógica do mercado. Os resultados revelam que tais lógicas influenciam as práticas e símbolos nas OEAFs, moldando o comportamento organizacional.
SUICÍDIO NO MEIO RURAL: UMA REVISÃO INTEGRATIVA
Authors: Schoeninger Bruna Caroline , Magro Marcia Luiza Pit Dal
Published: June 2021

De acordo com a Organização Mundial da Saúde, o suicídio se configura como um sério problema de saúde pública, sendo que as mortes por suicídio têm aumentado nas últimas décadas. As mortes autoprovocadas também afetam os contextos rurais, que vem passando por transformações importantes nos modos de vida e trabalho. Este artigo teve como objetivo analisar como a produção científica publicada no período de 2013 a 2018 abordou o fenômeno do suicídio no meio rural. Para tanto, foi realizada revisão integrativa, a partir de das bases de dados Google Acadêmico e Biblioteca Virtual de Saúde, tendo sido selecionados 17 artigos para análise. Foram elaboradas três categorias a partir dos resultados encontrados, que mostram os principais temas abordados pelos estudos. O primeiro diz respeito ao suicídio relacionado às transformações de vida e de produção no meio rural, que foi mencionado em 5 artigos. O segundo tema mais abordado foi a relação entre o uso de agrotóxicos e o suicídio, mencionado por 11 artigos. O último se refere às características demográficas e étnicas nos contextos rurais, em que se destaca a relação entre suicídio, sexo e idade, e estudos que analisam a ocorrência de suicídios entre as etnias alemã e indígena. Conclui-se que os estudos dão ênfase a fatores de riscos específicos como o uso de agrotóxicos, tendo uma lacuna de estudos que integrem diferentes fatores de risco. Há ausência de estudos que tragam como ênfase modos de prevenção do suicídio nos contextos rurais.
Prácticas evaluativas en contextos de aula invertida y aprendizaje móvil
Authors: Morán Lourdes
Published: June 2021

En los últimos años los modelos pedagógicos del nivel superior han mostrado una gran extensión hacia el blendedlearning (Ibáñez, de Benito Crosetti, Garcías, y Cervera, 2018; Mariño, 2007; Morán, 2012; Vera, 2008). El modelo permite combinar el ambiente presencial y el virtual, de tal forma que permite la optimización de las cualidades más pujantes de cada uno de ellos. Entre las diferentes formas de implementar el blendedlearning es el modelo del aula invertida (Coufal, 2014; Schneider, Suhr, Rolon, y Almeida, 2013), el cual ha ido adquiriendo progresivamente mayor relevancia. En estos contextos el profesorado afronta la transformación de todas sus prácticas, entre ellas, la evaluación resulta un eje relevante que ha sido poco abordado. Con base en esta problemática, la investigación que se presenta en este trabajo abordó la evaluación llevada a cabo en tres asignaturas. Se indagó acerca del enfoque, las estrategias y los instrumentos, con el fin de establecer las particularidades de la evaluación en estos contextos. Por medio de un abordaje cualitativo, se recolectó información mediante entrevistas, observaciones y análisis documental. Asimismo, se siguió el método comparativo constante y se construyeron las categorías que permitieron caracterizar evaluación en contextos de aula invertida. Las decisiones y acciones en torno a la evaluación evidencian cómo la propuesta pedagógica y las posibilidades didácticas de las actividades, definen la impronta de la evaluación más que las cualidades de las herramientas tecnológicas.
Una experiencia virtual de aprendizaje sobre la educación estocástica inicial con estudiantes costarricenses de secundaria
Authors: Fallas-Soto Rodolfo
Published: June 2021

Este estudio tiene como objetivo desarrollar, por medio de un entorno virtual, un espacio para la construcción de significados que se asocien con los conceptos básicos de estadística, como parte del proyecto de Comunidades de Aprendizaje Matemático de la Universidad de Costa Rica y los cursos libres que imparte. Para ello, desde el enfoque socio-epistemológico, se desarrollan las etapas de la ingeniería didáctica para implementar en un grupo de 30 estudiantes (entre 14 y 15 años) el ciclo de investigación estadística propuesto por (Wild y Pfannkuch, 1999).  En los resultados se muestran dos organizaciones de prácticas asociadas al actuar del estudiantado cuando comprenden comportamientos de naturaleza estocástica. Además, esta investigación reporta el papel del cambio en la muestra estadística, para asegurar una representatividad de la población de estudio. Se concluye con algunas características de la práctica de inferencia y su relación con una forma de pensar ante comportamientos no deterministas.
The left atrial appendage amputation during off-pump coronary artery bypass grafting prevents stroke
Authors: Endo Daisuke , Asai Tohru , Yamamoto Taira , Oishi Atsumi , Yokoyama Yasutaka , Shimada Akie , Kajimoto Kan , Matsushita Satoshi , Dohi Shizuyuki , Amano Atsushi
Published: June 2021

Background: Postoperative atrial fibrillation (POAF) occurs in 20% to
50% of patients soon after cardiac surgery, and is associated with
subsequent newly developed AF. Left atrial appendage closure is
effective in preventing stroke among patients with nonvalvular AF.
However, the prophylactic effect of left atrial appendage amputation
(LAAA) in stroke prevention among patients with sinus rhythm has not
been proven. Methods: We analyzed 977 consecutive patients undergoing
off-pump coronary artery bypass grafting (OPCAB) with sinus rhythm, with
or without concomitant LAAA, from 2011 to 2017 at our institution in a
retrospective observational manner. A total of 550 patients (56.3%)
underwent concomitant LAAA, any effect thereof in preventing early
(<30 days) and later stroke was examined. Results: The
incidences of POAF and early stroke were not significantly different
between the groups. The incidence of later stroke was higher in patients
without LAAA than in those with LAAA (4.0% vs. 1.6%; p = 0.02). In a
subanalysis of patients without LAAA, stroke occurred more frequently in
those with POAF than those without POAF (7.5% vs. 2.7%; p = 0.03),
while in patients receiving LAAA, stroke incidences did not differ
between those with and without POAF. Multivariate cox proportional
hazard model showed POAF without LAAA was the only independent predictor
of stroke (HR: 2.86; 95% CI: 1.10 to 7.45; p=0.03). Conclusions:
Concomitant surgical LAA amputation during OPCAB reduces the risk of
stroke.
Vero cells gain renal tubule markers in low-calcium and magnesium chemically defined media
Authors: Logan Megan , Rinas Karsten , McConkey Brendan , Aucoin Marc
Published: June 2021

In this study, a chemically defined, animal component-free media was
developed to promote Vero growth in suspension. Key media compounds were
screened using Plackett-Burman styled experiments to create a media
formulation to support suspension growth. Vero cells remained viable in
suspension, but their growth rate was extremely low, conversely, other
cell types such as CHO-K1, MDCK and HEK293T were able to grow in single
cell suspension in the same media. To investigate the slow growth of
Vero cells, RNA-Seq analysis was conducted. Vero cells were cultured in
three different conditions: adherently in serum-containing medium,
adherently in in-house medium, and in suspension in low calcium and
magnesium in-house medium. This study illustrates that adherent cells
maintain similar gene expression, while the suspension phenotype tends
to overexpress genes related to renal tubules.
Identifying Healthcare Professionals' Fear of COVID-19 and Their Attitudes towards Being Vaccinated
Authors: Ergin Eda , AKKOYUN Semih
Published: June 2021

Objective: This study was conducted to determine healthcare
professionals’ fear of COVID-19 in and their attitudes towards being
vaccinated against COVID-19. Method: The sample of this descriptive
study was composed of 302 healthcare professionals working in a
university research and training hospital. The data were collected with
the help of an online survey method created with the help of Google
Forms using the “Form for Determining Healthcare Professionals’
Attitudes towards Being Vaccinated” and “The Fear of COVID-19 Scale”
between December 28, 2020 and January 13, 2021. Results: The mean total
Fear of COVID-19 Scale score of the healthcare professionals
participating in the study was found to be 17.20 ± 6.015. A significant
relationship was found between the Fear of COVID-19 Scale total score
and participating healthcare professionals’ gender, status of education,
status of flu vaccination and status of being diagnosed with COVID-19 (p
<0.005). Conclusion: According to research results, it was
found that healthcare professionals experienced moderate fear, almost
half of them were undecided about the COVID-19 vaccine, their thoughts
about vaccination were positive and they were mostly concerned about the
side effects of the vaccine.
Programmed Cell Death 1 Receptor / Programmed Death-Ligand1 (PD‐1/PD‐L1 ) Inhibitors Alone or with Conventional Therapy versus Standard of Care for Head and Neck Cancer: A Systematic Review and Meta-Analysis
Authors: Huang Xin , Zhang Jie , Ruan Hongying
Published: June 2021

Objectives As a pivotal part of precision therapy, PD‐1/PD‐L1
immunotherapy has been gradually used in head and neck cancer (HNC). We
investigated the effect and adverse events of PD‐1/PD‐L1 inhibitors
alone or with conventional therapy. Design The groups using PD-1/PD-L1
immunotherapy or combining with conventional therapy were defined as the
experimental groups, while the standard of care were the control groups.
Cochrane Library, Embase, PubMed, and Web of Science were undertaken to
identify literature up to November 20, 2020. Overall survival (OS) and
progression-free survival (PFS) were the primary outcome measures.
Secondary outcome measures included objective response rate (ORR),
disease control rate (DCR), any grade and grade≥3 adverse events (AE).
Results Five randomized controlled trials (RCTs) and nine single-arm
trials were included in the systematic review. The OS of the
experimental groups was better than the control groups (OR = 0.63,
95%CI: 0.49‐0.82, I²=35%, P=0.0004), particularly in patients who
smoke current/former or with human papillomavirus negative (HPV-). The
experimental groups had longer OS than the control groups in patients
with PD-L1 positive (OR = 0.75, 95% CI: 0.65‐0.85, I²=0%,
P<0.0001). Patients with HPV positive (HPV+) had more
favorable OS than those with HPV- (OR = 0.56, 95%CI:0.44-0.71, I²=39%,
P<0.00001). There were statistical differences in AEs (e.g.,
fatigue, rash, hypothyroidism, etc.) and no statistical differences in
PFS, ORR, and DCR. Conclusion PD-1/PD-L1 immunotherapy or combining with
conventional therapy can improve the treatment effect and induce fewer
adverse events of digestion and blood system, except for hypothyroidism.
Density functional theory calculations and molecular docking of 2-phenylbenzimidazoles with estrogen receptor for quantitative structure-activity relationship studies
Authors: Madadi Mahani , Mohammadi Sayed , Anjomshoa Khadije
Published: June 2021

Benzimidazole derivatives, especially 2-phenylbenzimidazole with various substituents on the C-5, C-2 and C-6 positions, are so important in pharmaceutical chemistry. Multiple linear regression was applied to predict the activity of 27 novel 2-phenylbenzimidazole derivatives as anticancer agents. At first, we made an effort to create a QSAR model for a selected series of novel 2-phenylbenzimidazole with density functional theory and molecular docking descriptors. Then, we tried to investigate the nature of the interactions between 2-phenylbenzimidazole derivatives and the estrogen receptor using the molecular docking method. Six descriptors of MATS4e, GATS5e, R6v, R1v+, dipole moment, and torsional free energy were selected for modelling. Due to docking results, increase in the binding energy, and decrease in the dipole moment could increase inhibitor activity.
Increased Hemoglobin A1c Time in Range Reduces Adverse Health Outcomes in Older Adults With Diabetes
Authors: Prentice Julia C. , Mohr David C. , Zhang Libin , Li Donglin , Legler Aaron , Nelson Richard E. , Conlin Paul R.
Published: June 2021

OBJECTIVE

Short- and long-term glycemic variability are risk factors for diabetes complications. However, there are no validated A1C target ranges or measures of A1C stability in older adults. We evaluated the association of a patient-specific A1C variability measure, A1C time in range (A1C TIR), on major adverse outcomes.

RESEARCH DESIGN AND METHODS

We conducted a retrospective observational study using administrative data from the Department of Veterans Affairs and Medicare from 2004 to 2016. Patients were ≥65 years old, had diabetes, and had at least four A1C tests during a 3-year baseline period. A1C TIR was the percentage of days during the baseline in which A1C was in an individualized target range (6.0–7.0% up to 8.0–9.0%) on the basis of clinical characteristics and predicted life expectancy. Increasing A1C TIR was divided into categories of 20% increments and linked to mortality and cardiovascular disease (CVD) (i.e., myocardial infarction, stroke).

RESULTS

The study included 402,043 veterans (mean [SD] age 76.9 [5.7] years, 98.8% male). During an average of 5.5 years of follow-up, A1C TIR had a graded relationship with mortality and CVD. Cox proportional hazards models showed that lower A1C TIR was associated with increased mortality (A1C TIR 0 to <20%: hazard ratio [HR] 1.22 [95% CI 1.20–1.25]) and CVD (A1C TIR 0 to <20%: HR 1.14 [95% CI 1.11–1.19]) compared with A1C TIR 80–100%. Competing risk models and shorter follow-up (e.g., 24 months) showed similar results.

CONCLUSIONS

In older adults with diabetes, maintaining A1C levels within individualized target ranges is associated with lower risk of mortality and CVD.
Hand Grenades in the Kitchen: a commentary on The Murenger and Other Stories and Rebel Rebel
Authors:   , Gower David J.
Published: June 2021

The published works being submitted, The Murenger and Other Stories and Rebel Rebel are, respectively, collections of 15 and 21 short stories. They form part of a substantial body of almost ninety short stories, gathered in five collections over three decades by the author. They represent a contribution to the short story in both English and Welsh and offer evidence of experiment with the form. The critical review examines some of the technical aspects of crafting these short stories and considers some of the disparate themes in these volumes, such as Brexit, nature and David Bowie. It also sets the collections within the context of both the writer’s other outputs and the work of other authors such as Gabriel García Márquez, John Updike and Kevin Barry whose influence has made its mark. It also considers issues arising from being a bilingual writer and applies some ideas about literary cartography to the two volumes under consideration.
ADVERTISING IN THE INTERNET: THEORETICAL ANALYSIS AND FEATURES
Authors:   National University of Water and Environmental Engineering, Malchyk M. , Adasiuk I. ,   National University of Water and Environmental Engineering
Published: June 2021

Purpose. The purpose of the article consists of theoretically analyzing advertising on the Internet and determining its species’ characteristics. Design/methodology/approach. The following methods were used in the research process: generalization, synthesis, grouping, induction, deduction, vertical, horizontal, tabular. Findings. This article highlights the analysis of the leading indicators of the Internet advertising market and the most popular advertising types in the network. Internet advertising’s main tasks as an essential tool of the marketing strategy of any kind of activity, a form of enterprise ownership, and business size are revealed. The classification of Internet advertising has been improved, where the main types are grouped according to the eleven features. The essence of every kind of advertising is revealed, the theoretical understanding of which will allow the advertiser to make an effective decision on the feasibility of advertising tools, settings, minimizing risks in promotion, rational use of the advertising budget, and improving performance end of the show. A comparative assessment and features of the most popular types of advertising on the network revealed the advantages and disadvantages of Internet advertising to improve its theoretical analysis. Practical implications. The constant dynamics of the Internet market create an increase in advertising requirements on the part of the advertiser and the target audience. Advertising settings and targeting are systematically updated, some types of advertising are losing popularity, and others are being replaced. There are many problems in promoting products on the Internet, so this topic needs to improve the theoretical and practical approaches to the use of advertising on the Internet as part of enterprises and organizations’ business strategy. Originality/value. The development of the information society and the Internet affect people’s lives and new communication links in the business. Business on the Internet is not an advantage among competitors but a necessary condition in the marketing strategy. There is the growth of Internet users, the emergence of new advertising tools, thematic portals, search engines, websites, advertising platforms contributes have to make effects to the development of the Internet advertising market.
BUSINESS TOURISM AS A PROSPECTIVE DIRECTION OF TOURISM ACTIVITY IN UKRAINE
Authors:   Lviv Polytechnic National University, Prokopyshyn-Rashkevych L.
Published: June 2021

Purpose. The purpose of this research is to reveal the concept of the “business travel” and improve its classification in accordance with certain areas; to analyze indicators of tourist activity, including the trends of business tourism in Ukraine; to identify the features of business tourism development in some regions of Ukraine. Design/methodology/approach. Such scientific theoretical research methods as analysis and synthesis, systematization and explanation have been used to understand the definition of “business tourism” and its classification in certain areas. Methods of comparative and statistical analysis were used to study changes in the structure of tourism and identify trends in business tourism in some regions of Ukraine. Findings. The hypothesis that business travel has the opportunity to be developed in some regions of Ukraine is proven. The tourist situation in Ukraine has been analyzed in accordance with the data of State Statistics Service and Administration of the State Border Guard Service. Having investigated the tendency of business tourism in some regions of Ukraine, it can be noticed an increase in the total number of business tourists, who used the services of tour operators and travel agents during the period 2017–2018. Odessa, Dnipro regions and Kyiv are the centers of different business events, meetings and business interests. There is big amount of already existing exhibitions, fairs and business events which attract both domestic and foreign tourists. Practical implications. The results of this research have practical implications. Some travel companies, located in Odessa, Dnipro regions and Kyiv can diversify their activity, adding business travel as a prospective direction. Also, the state should support business, especially during pandemic period, encouraging safe travel, promoting information to tourists, taking care of the country’s image at both regional and international level. Originality/value. Business travel is considered as a type of tourist activity, undertaken for solving business purposes and also includes cultural and entertainment programs. The main groups of participants in business travel are identified and the most dynamic segment of the business travel market is indicated. The distribution of foreign tourists related to various types of tourism activity is analyzed and the potential for business travel development in separate regions is defined.