bluuebunny/crossref_metadata_2025 huggingface dataset:
Hubungan Kepercayaan dan Tradisi Keluarga pada Ibu Menyusui dengan Pemberian ASI Eksklusif di Kelurahan Sidotopo, Semampir, Jawa Timur
Authors: Setyaningsih Fifin Triana Enita , Farapti Farapti
Published: March 2019

Exclusive breastfeeding is one effort made to suppress infant mortality rate. The failure of exclusive breastfeeding practices is closely related to the behavior of breastfeeding. Social culture brings about traditions and beliefs that are often used as guidelines for behavior in the community. Belief has formed into a thing that is beliefed and will be the basis for a person to behave. Tradition is obtained through generations and become individual habits. The purpose of this study is to assess the relationship between exclusive breastfeeding and belief and tradition.This is an analytic research with cross sectional approach. Random sampling technique was used. The population was all breastfeeding mothers who had babies aged 6-12months. The sample obtained were 57respondents. The variables studied were breast feeding mothers’ beliefs and traditions  on exclusive breastfeeding. Beliefs about giving complimentary foods to infants and the breastfeeding-related traditions in the community were associated with the implementation of exclusive breastfeeding.  Data analysis showed that there was a significant relationship between belief (p value = 0,045) and tradition (p value = 0,019) with exclusive breastfeeding in RW XI of Kelurahan Sidotopo. In conclusion, there is a relationship between belief and tradition in society with practice of exclusive breastfeeding. It is recommended that all sectors address belief and traditions in the effort to support exclusive breastfeeding programs.
Bayi Berat Lahir Rendah (BBLR) di Provinsi Jawa Timur Tahun 2012-2016
Authors: Hartiningrum Indri , Fitriyah Nurul
Published: March 2019

LBW classified as one of children health problems in Indonesia which impacts Infant Mortality Rate (IMR). According to Riskesdas 2010, LBW in Indonesia was noted approximately 11,1%, while in East Java was noted approximately 10,1%. This study aims for knowing a pattern of LBW on the 5 years latest in the East Java since that LBW is regarded as the public health indicator because it affects bigger for the children’s life in further. This study was descriptive research within quantitative approach using the secondary source from Health Profile of East Java Province during 2012 until 2016. Based on this method, city has a large number of LBW patience are Madiun (8.6%), Situbondo (5%) and Bondowoso (4.6%). Pattern of LBW cases in East Java were fluctuative and did not change to better yet. In conclusion, 3 cities who have the high percentage number of LBW was caused an illness during the women’s pregnant and the lack of knowledge about the nutrition proposition. It showed that the program who done by the government for decreasing the number of LBW in East Java was not efficient yet, so, it is needed an intervention in advance.
Pencapaian Kepentingan Korea Selatan melalui Diplomasi Publik Korean Wave
Authors: Trisni Sofia , Isnarti Rika , Sinulingga Anita Afriani , Ferdian Ferdian
Published: March 2019

Diplomasi publik merupakan instrumen pencapaian kepentingan negara yang populer digunakan, dimana Republic of Korea merupakan salah satu contoh negara yang menggunakan diplomasi publik dengan Korean wave menjadi salah satu medianya. Diplomasi publik Korean wave meraih kesuksesannya di Indonesia secara umum dan kota Padang secara khusus. Tulisan ini bertujuan untuk mendeskripsikan pencapaian kepentingan negara melalui pelaksanaan diplomasi publik yang  melibatkan banyak aktor swasta/private. Penulis menggunakan  metode survei ke sepuluh universitas yang ada di kota Padang untuk mengetahui pencapaian kepentingan negara ini di kota Padang. Tulisan ini menemukan bahwa walaupun diplomasi publik ini berhasil dalam meningkatkan popularitas Republic of Korea, tetapi kepentingan yang ingin dicapai seperti tersosialisasikannya kebijakan pemerintah dan penciptaan image  RoK yang cinta damai dan attractive belum berhasil tercapai sepenuhnya, karena ketertarikan kepada budaya populer yang ditawarkan ternyata tidak berhasil untuk menarik pemuda kota Padang untuk lebih lanjut mempelajari kebijakan-kebijakan pemerintah dan membangun image yang diinginkan oleh pemerintah. Kata kunci : Diplomasi Publik, Korean wave, image, budaya populer, Padang
Trade Effects Based on Trade Equilibrium
Authors: Guo Baoping
Published: March 2019

The Rybczynski theorem describes the trade effect within production analyses between factor endowments and outputs. The Stolper-Samuelson theorem focuses on cost analyses between factor reward and commodity price. This paper examines the trade effect of changes of factor endowments on prices, based on general equilibrium. The study shows that changes of factor endowments cause domestic output changes (the Rybczynski effect), which affect output prices and factor prices (the Stolper-Samuelson effect). It is like a chain of effects that the Rybczynski’s trade effect triggers the Stolper-Samuelson’s trade effect. The analysis of this paper shows that a small increase of a factor endowment of any country rewards another factor and the commodity using the latter factor intensively. It displays a tuneful circle. Trade brings a well-balanced development to the world.
STEM in English for Early Childhood Ecological Awareness in China
Authors: Zhao Wenxiao
Published: March 2019

Changes in curricula, publication policy and information technology, notably in China have led to concentrations in the role of STEM (science, technology, engineering and mathematics) education in early childhood and applauded to proliferations of imported up-to-date reading materials and mobile apps in English. This paper proposes a longitude study of a Chinese toddler learning STEM by reading picture books and playing with tablet and suggests new horizons in parenting and in STEM education during children's early years. The present study carried out from 2016, when the participant reached one year old, eligible to learn to speak and to concentrate on the picture books read by parents who had filled a language background questionnaire with information on themselves and the participant. Tablet playing brought about for the two-year-old toddler and collections of STEM books in English was added for the second year. Data collection lasted for two years with an iLab video camera, capturing utterances and motions for five minutes per week transcribed by VoiceScript software. Tests were given quarterly at private home by tapping in mobile app "Bilingual Child Learning" which consists of 20 basic STEM themes before scores were collected. Findings indicate that (1) it is accessible for children of very early years to be engaged in English STEM resources, (2) kids' limited English dominance does not impede learning STEM, (3) and to think in English in early STEM contributes to children's English.
Total and Ionized Calcium and Magnesium Are Significantly Lowered in Drug-Naïve Depressed Patients: Effects of Antidepressants and Associations with Immune Activation
Authors: Al-Dujaili Arafat Hussein , Al-Hakeim Hussein Kadhem , Twayej Ahmed Jasim , Maes Michael
Published: March 2019

Major depressive disorder (MDD) is associated with changes in the levels of the cations calcium (Ca) and magnesium (Mg) as well as circulating pro- and anti-inflammatory cytokines. The immune-inflammatory nature of MDD has encouraged researchers to use anti-inflammatory drugs as an adjuvant treatment for MDD. However, the effect of this treatment on cation levels has not been studied. The present study examined a) differences in both cations between drug-naïve MDD patients and controls, and b) the effects of a combination of sertraline and ketoprofen, an anti-inflammatory drug, on Ca and Mg (both total and ionized). In the same patients we also examined the associations between both cations and IL-1β, IL-4, IL-6, IL-18, IFN-γ, TGF-β1, zinc and indoleamine 2,3-dioxygenase (IDO). Clinical improvement was estimated using the Beck Depression Inventory-II (BDI-II) at baseline and after follow up for two months. Serum Ca and Mg (total and ionized) were significantly lower in MDD patients as compared with controls, while treatment significantly increased calcium but decreased magnesium levels. There were significant and inverse correlations between the BDI-II scores from baseline to endpoint and Ca (both total and ionized), but not Mg, levels. The effects of calcium on the BDI-II score remained significant after considering the effects of zinc, IDO and an immune activation z unit weighted composite score based on the sum of all cytokines. There was a significant and inverse association between this immune activation index and calcium levels from baseline to endpoint. In conclusion, reduced levels of both cations play a role in the pathophysiology of major depression. Increased calcium levels are coupled to the clinical efficacy of antidepressants and attenuation of immune activation. The suppressant effect of antidepressants on Mg levels may be a side effect of those drugs. New antidepressant treatments should be developed that increase the levels both Ca and Mg.
The Development of Silica Hydride Stationary Phases for High Performance Liquid Chromatography from Conception to Commercialization
Authors: Matyska Maria , Pesek Joseph
Published: March 2019

The development of a stationary phase material for high performance liquid chromatography based on a surface of silica hydride as opposed to silanols on ordinary silica is discussed including synthetic approaches, characterization and applications.  There are several synthetic approaches available to create a silica hydride surface.  Modification of the Si-H moiety on the silica surface can be accomplished through use of a hydrosilation reaction.  Both the intermediate silica hydride and the material modified with an organic moiety can be characterized by a number of spectroscopic as well as a variety of other methods.  Further insights into the retention mechanism are provide through chromatographic measurements.  The ultimate utility of any chromatographic stationary phase material is determined by its success for solving challenging analytical problems.  A broad range of applications are reviewed to illustrate the versatility and usefulness of silica hydride-based stationary phases. 
Visualizing Biological Membrane Organization and Dynamics
Authors: Baaden Marc
Published: March 2019

Biological membranes are fascinating. Santiago Ramón y Cajal, who received the Nobel prize in 1906 together with Camillo Golgi for their work on the nervous system, wrote “[..]in the study of this membrane[..] I felt more profoundly than in any other subject of study the shuddering sensation of the unfathomable mystery of life”[1]. The visualization and conceptualization of these biological objects have profoundly shaped many aspects of modern biology, drawing inspiration from experiments, computer simulations, as well as from the imagination of scientists and artists. The aim of this review is to provide a fresh look on current ideas of biological membrane organization and dynamics by discussing selected examples across fields [1] The full quotation is “I must not conceal the fact that in the study of this membrane I for the first time felt my faith in Darwinism (hypothesis of natural selection) weakened, being amazed and confounded by the supreme constructive ingenuity revealed not only in the retina and in the dioptric apparatus of the vertebrates but even in the meanest insect eye. There, in fine, I felt more profoundly than in any other subject of study the shuddering sensation of the unfathomable mystery of life.” from the autobiography Recollections of My Life.
Ostrowski Type Inequalities Pertaining Strongly Convex Functions Via Conformable Fractional Integrals and Their Applications
Authors: Kashuri Artion , Liko Rozana
Published: March 2019

In the article, by applied the concept of strongly convex function and one known identity, we establish several Ostrowski type inequalities involving conformable fractional integrals. As applications, some new error estimations for the midpoint formula are provided as well.
An Elevated High-Density Lipoprotein Cholesterol Levels Is Associated with Favorable Outcomes of Patients with Small-Artery Occlusion
Authors: Ruixiao Hao , Peipei Liu , Yajing Wang , Wu Jialing
Published: March 2019

Background: The relationship between high-density lipoprotein (HDL) cholesterol and small-artery occlusion (SAO) is not well understood.
Methods: A total of 3067 consecutive patients with SAO were recruited from Tianjin Huanhu Hospital between January 01, 2008, and December 31, 2015. HDL values at admission were classified into four groups according to quartiles (<0.92, 0.92–1.08, 1.08–1.28, and ≥1.28). Patients were followed up to 12 months after stroke. Prognoses, represented by modified Rankin scale (mRS), were estimated via HDL quartiles upon admission utilizing multivariate logistic regression analysis. Meanwhile, we conducted additional subgroup analyses to investigate associations according to age.
Results: Among 3067 patients, 2284(74.5%) were classified as having favorable outcomes, 783(25.5%) had a composite of poor outcomes,recurrent stroke, myocardial infarction or vascular death within 12 months. After adjustment for possible confounders, HDL levels in the two highest quartiles (1.08–1.28 and ≥1.28) were correlated with the 12-month primary outcome of patients with SAO (1.08–1.28 , 0.587; 95% CI,0.394-0.873; P = 0.009; ≥1.28, 0.448; 95% CI, 0.291-0.688; P < 0.001). However, a direct correlation was found in patients aged 45–75 years (1.08–1.28, P = 0.033; ≥1.28, P = 0.001).Similar to the primary outcome,a direct correlation was also found in patients aged 45–75 years with a 12-month secondary outcomes(≥1.28 mmol/L, p = 0.001).
Conclusions: An elevated HDL cholesterol level in patients with SAO is an independent predictor of a favorable prognosis 12 months after SAO. However, the association was only present in patients aged 45–75 years.
Keywords: High-Density Lipoprotein Cholesterol, Stroke, Outcome, Small-Artery Occlusion.
Effects of Nonwoven Polypropylene Covering during Overwintering on Growth and Bulb Yield of Intermediate-day Onion
Authors: Lee Jongtae , Min Byeonggyu , Kim Heedae , Kim Juyeon , Kwon Young-Seok , Boyhan George E.
Published: March 2019

This study evaluated the effects of a nonwoven polypropylene (NPP) covering during overwintering with different mulch types and transplant times on bulb onion growth and yield of intermediate-day onions (Allium cepa L.) during the 2015/2016 and 2016/2017 growing seasons. Field experiments were conducted using a split-split plot design with three replicates. Treatments included main plots containing different mulch types (transparent plastic mulch, black plastic mulch, or bare ground), subplots with different transplanting times (20 Oct., 5 Nov., and 20 Nov.), and sub-subplots containing two onion cultivars (Sunpower and Katamaru). NPP was used to cover all plots on 1 Dec., and it was removed on 28 Feb. Mean daily air temperatures during transplanting and root establishment were 2.6 °C higher during the 2015/2016 growing season compared with the 2016/2017 season. NPP covering on bare ground increased soil temperature by 2.1 °C compared with no treatment. Soil water potential with transparent and black mulches and NPP continued to be more than −10 kPa until early March. Number of leaves, and root and leaf weight were significantly greater during the 2015/2016 growing season than during the 2016/2017 growing season; there were also significantly greater for onion plants grown with transparent plastic mulch than for those grown with black plastic mulch or no mulch on 4 Apr. and 5 May. Marketable bulb yield was lower during 2015/2016 (32.0 Mg·ha−1) than during 2016/2017 (38.5 Mg·ha−1); this was due to the increased unmarketable bulb yield, with 33.2 Mg·ha−1 bolters and 3.9 Mg·ha−1 doubled bulbs during 2015/2016 compared with 3.9 Mg·ha−1 bolters and 0.3 Mg·ha−1 doubled bulbs during 2016/2017. Marketable bulb yield of ‘Katamaru’ (38.9 Mg·ha−1) was greater than that of ‘Sunpower’ (31.6 Mg·ha−1). Marketable bulb yield increased with later transplanting times, and onions grown with black plastic mulch achieved the highest bulb yield (43.0 Mg·ha−1), followed by transparent mulch (34.7 Mg·ha−1) and no mulch (28.0 Mg·ha−1). When the temperatures from early November to early December were similar to the 30-year average temperatures, marketable bulb yield could increase with the NPP covering, especially for onions grown with black plastic mulch or no mulch when transplanted from late October to early November.
Transferability of Microsatellite Markers across Eleven Species of Magnolia L.
Authors: Thammina Chandra S. , von Kohn Christopher , Pooler Margaret R.
Published: March 2019

The genus Magnolia (Magnoliaceae) comprises more than 130 species distributed predominantly in temperate and tropical regions in Southeast Asia and is valued worldwide for its ornamental traits as well as for timber and medicinal products, and in trade. Despite their favored status, many species of Magnolia are faced with threats from logging, agricultural land use, development, and collection, and are at risk of extinction. Conservation of these species through habitat preservation and in ex situ collections is needed to prevent extinction. To provide a tool for conservation of Magnolia species, microsatellite markers developed previously for Magnolia ashei were tested in 10 other species of Magnolia to determine their transferability across species. Of the 64 primer pairs tested, 21 amplified alleles in the expected size range in all samples; 11 primer pairs amplified clean products in most, but not all, species; 18 primer pairs consistently amplified a polymerase chain reaction (PCR) product in most species, but had either low peak height or other amplification issues; and 14 primers showed excessive stutter, nonspecific amplification, or no amplification. Cluster analysis using the 129 alleles amplified by these 21 simple sequence repeat (SSR) primer pairs generated groups that corresponded to the known taxonomic relationships in this genus.
Resistance Identification of Tree Peony Cultivars of Different Flowering Time to Gray Mold Pathogen Botrytis cinerea
Authors: Tian Yuee , Che Zhiping , Sun Di , Yang Yuanyuan , Lin Xiaomin , Liu Shengming , Liu Xiaoyu , Gao Jie
Published: March 2019

Tree peonies are valuable ornamental plants and are widely cultivated in China and many other countries. Gray mold caused by Botrytis cinerea is an increasingly severe disease in Luoyang of China and seriously affects the ornamental value of tree peonies both in the open air and in greenhouses. However, the resistance of different tree peony cultivars to B. cinerea remains unknown. In this study, 15 tree peony cultivars belonging to three different flowering times were evaluated for resistance to B. cinerea by detached leaf assay measure. Results showed that the resistance of early-flowering peonies was stronger than that of later flowering peonies. Moreover, the correlation between flowering time and resistance of tree peonies was extremely significant (P < 0.01). The information obtained in this study can provide theoretical basis both for further exploring the resistance genes of tree peony to B. cinerea and for the prevention and controlling of the gray mold.
Inter- and Intracultivar Variation of Heirloom and Open-pollinated Watermelon Cultivars
Authors: Stone Suzanne , Boyhan George , McGregor Cecilia
Published: March 2019

Watermelon [Citrullus lanatus (Thunb.) Matsum. & Nakai] cultivars exhibit diverse phenotypic traits, yet are derived from a narrow genetic base. Heirloom cultivars, and to a lesser extent modern open-pollinated (OP) cultivars, are perceived to contain vital genetic variation that is critical for biodiversity conservation and crop improvement. The objective of this study was to characterize the diversity of six heirloom and open-pollinated watermelon cultivars that are popular among U.S. organic, direct-market, and home gardeners. An additional evaluation was conducted to determine whether significant phenotypic and genotypic variation existed among seed lots sourced from different commercial seed vendors. Important horticultural traits such as days to germination, days to first flower, yield, and fruit quality were measured over two field seasons. Genetic diversity was estimated using 32 simple sequence repeat (SSR) markers. Significant differences in horticultural traits among seed lots in both years were observed only in days to germination and first male flower, which may be a consequence of vendor differences in seed storage and quality control. Heirloom ‘Moon and Stars’ and modern OP ‘Sugar Baby’ were the most genetically distinct from the other cultivars and heirloom ‘Georgia Rattlesnake’ was determined to be highly related to the modern OP ‘Charleston Gray’. The two heirloom cultivars were observed to have lower average gene diversity than the modern cultivars. Heirloom ‘Moon and Stars’ contained significant genetic variation among seed lots, yet heirloom ‘Georgia Rattlesnake’ contained none. These findings suggest that genetic variation can be more accurately attributed to pedigree and foundation seed maintenance practices than to the “heirloom” designation per se. The variation reported in this study can be used to inform conservation and breeding efforts.
Container Production of Southern Highbush Blueberries Using High Tunnels
Authors: Li Tongyin , Bi Guihong
Published: March 2019

Blueberry production in Mississippi (MS) is mainly rabbiteye blueberries (Vaccinium virgatum Ait.), which ripen in late May to June. Growing early-ripening southern highbush blueberries (SHBs) (Vaccinium corymbosum L.) presents an opportunity for early fruit production and increased market price for locally produced blueberries, yet faces the challenge of spring frost damage. One-year-old liners of 10 SHB cultivars were transplanted into 15-gallon plastic containers and placed in a high tunnel in Apr. 2015. Blueberry plants were fertilized with either a conventional or an organic fertilizer at comparable rates. Plants were evaluated for berry yield, timing of first berry harvest and peak harvest, single berry weight, and soluble solid content during the 2016 and 2017 growing seasons. The high tunnel increased monthly maximum temperature by 3.2 to 10.4 °C, monthly average temperature by 0.7 to 4.2 °C, and minimum monthly temperature for up to 3.0 °C compared with outdoor environment. Photosynthetically active radiation (PAR) at noon in the high tunnel ranged from 477 to 1411 µmol·m−2·s−1 and relative humidity ranged from 54.6% to 81.7% from Jan. 2016 to June 2017. SHBs in the high tunnel produced first berry harvest during the first week of April in both growing seasons. Total berry yield per plant ranged from 921 g to 2136 g in 2016 and from 1222 g to 2480 g in 2017. Compared with the organic fertilizer, conventional fertilizer increased berry yield in April and May, and total berry yield in 2016, but resulted in similar yield in 2017. Eight cultivars (Emerald, Farthing, Gupton, Meadowlark, Pearl, Rebel, Star, and Sweetcrisp) produced single berries that averaged more than 2 g per berry in 2016, compared with two cultivars (Gupton and Pearl) in 2017. Smaller berry size may have resulted from the generally increasing yield from 2016 to 2017. ‘Sweetcrisp’ produced berries with higher soluble solid content, 14.2% and 14.1% in 2016 and 2017, than the other nine cultivars. Container production of SHB cultivars in a high tunnel produced total berry yield equivalent to 6458 kg/ha in 2016 to 7500 kg/ha in 2017, advanced blueberry production by 4 to 5 weeks, and therefore may serve as a potential production system for early fruiting blueberries in Mississippi.
Toxicity of Salicylic Acid in Cymbidium atropurpureo and Phalaenopsis Golden Peoker Cultivated In Vitro
Authors: Mantovani Cibele , de Souza Júnior Jonas Pereira , de Mello Prado Renato , Pivetta Kathia Fernandes Lopes
Published: March 2019

Salicylic acid (SA) may induce toxicity in orchids depending on its concentration and the plant species, but there is no information about the effect of this substance on orchids cultivated in vitro. The objective of the present study was to evaluate the effects of different concentrations of SA on Cymbidium atropurpureo and Phalaenopsis Golden Peoker cultivated in vitro to verify the biological losses caused by the substance’s toxicity. The orchids Cymbidium atropurpureo and Phalaenopsis Golden Peoker were sown in vitro in a Murashige and Skoog (MS)-growth medium and transferred to a medium of the same type containing SA 90 days after sowing. The studied SA concentrations were 0, 50, 100, 200, 300, 400, 500, and 1000 µmol·L−1, and the plants were kept in this medium for 210 days. The treatments were distributed into a completely randomized design with four replications. Biometric variables of the seedlings and electrolyte leakage were evaluated 300 days after sowing. The results indicate that the addition of SA interfered with the in vitro growth and development of seedlings of Cymbidium atropurpureo and Phalaenopsis Golden Peoker, given that it caused all the examined variables to show reduced values and triggered electrolyte leakage, consequently inducing toxicity.
Effects of Vacuum Packaging on Enzymatic Browning and Ethylene Response Factor (ERF) Gene Expression of Fresh-cut Lotus Root
Authors: Min Ting , Liu En-chao , Xie Jun , Yi Yang , Wang Li-mei , Ai You-wei , Wang Hong-xun
Published: March 2019

Ethylene response factor (ERF) genes have been involved in responses to biotic and abiotic stress, including hypoxia and anaerobic stress. Vacuum packaging (a typical anaerobic stress) is an effective storage method used to delay browning of fresh-cut lotus root (Nelumbo nucifera). In model plants, ERF genes have been identified as responsive to hypoxia. Whether ERF is associated with browning of vacuum-packaged lotus root has not been studied. The effects of vacuum packaging on browning, phenolic content, the enzyme activity of phenylalanine ammonia lyase (PAL), polyphenol oxidase (PPO), and peroxidase (POD), and PPO, PAL, POD, and ERF genes expression in fresh-cut lotus root were studied. Downregulation of NnPAL1, NnPPOA, and NnPOD2/3 attributable to vacuum packaging coincided with increased related enzyme activities and the degree of browning of fresh-cut lotus root. The expression patterns of NnERF4/5 were consistent with the changes in NnPAL1, NnPPOA, and NnPOD2/3 gene expression. It has been proposed that NnERF4/5 could have be important regulators of fresh-cut lotus root browning, and that the relationships of NnERF4/5 and NnPAL1, NnPPOA, and NnPOD2/3 should to be studied further.
Relation between Organisational Citizenship Behavior, Workplace Spirituality and Job Performance in BFSI sector in India
Authors: Habeeb Shaad
Published: March 2019

Companies across the world are struggling to keep the employees engaged and retained to their work. Moreover, today’s workforce is increasingly seeking intrinsic benefits beyond the material rewards of a job. In this context, this study aims to assess the relationship between organizational citizenship behavior (OCB), workplace spirituality (WS) and job performance (JP) in a non-Western setting where primary quantitative research was conducted in an Indian setting. The sector under study was Banking, Finance, and Insurance Services (BFSI), given retention issues since the financial crisis of 2008. A statistically evaluated sample of 433 respondents was utilized to attain the findings. Results revealed a statistically significant positive relationship between OCB, WS and JP that was achieved through regression analysis. However, findings also showed that OCB is not a moderator between WS and JP. The gap in the research was addressed given the lack of studies determining the impact of OCB on individual job performance. Further, the impact was positively highlighted in the Indian context. The implications to the BFSI sector were made that required companies to promote a culture for voluntary work practices to enhance JP.
Pathophysiological features of chronic cerebrovascular diseases and possibilities of complex neuroprotective therapy
Authors: Kostenko E. V. , Petrova L. V.
Published: March 2019

The article discusses the principles of neuroprotective therapy as a pathogenetically justified direction in chronic cerebrovascular diseases (CVD). The results of numerous clinical trials demonstrated efficacy, safety, a wide range of pharmacological effects and good tolerability of the powerful antioxidant Idebenone (Neyromet), as well as domestic cytoprotector, Choline alphosceratus of (Cerepro®), affecting the basic pathophysiological processes of the ischemic cascade at CVD. The role of rational multimodal pharmacotherapy of CVD, which provides the necessary energy for the processes of neuroprotection and neuroplasticity of brain cells, is emphasized.
Chronobiological features of primary headaches and the role of melatonin in the regulation of biological rhythms
Authors: Evdokimova E. M. , Poluektov M. G. , Tabeyeva G. R.
Published: March 2019

Frequency is considered as a key sign of the course of some forms of primary headaches (PH). One of the most prominent representatives is the hypnical and cluster headache, which predetermined their name. Clinical observations demonstrate a clear circadian rhythm and seasonal pattern of cluster headache (CH) and migraine (M) attacks. In accordance with modern concepts, the phenomenon of the periodicity of painful episodes of a number of forms of primary headaches is associated with dysfunction of the suprachiasmatic nucleus of the hypothalamus, the main pacemaker of biological rhythms. The connection of PH with chronopathology is confirmed by revealing the disturbances of melatonin secretion in CH and M. Melatonin has proven to be effective in treatment of these PH.
Stress analysis of rectangular and square plates with various cutouts
Authors: Pavan Kishore M. L. , Chandrashekhar A. , Avinash M. , Das Raunak
Published: March 2019

The geometric irregularities present inside a structure results in an improper stress distribution caused during manufacturing, which not only affects the strength of the component but also its vibrational behaviour when operated in a fluctuating environment. The emphasis of this paper is to evaluate the stress behavioral characteristics of plates with different cutout shapes. Two different loading conditions with three different types of plates made of Mild Steel are used for this analysis. From the present investigation, it may be concluded that where the max stress occurs. The methodology adopted in this research work is based on the numerical technique of finite element method, which uses SOLID 185 in ANSYS 19.1 solver. For further analysis, the obtained results are validated with previous literature works which were found satisfactory when related to the present study. It may be noted that FEM provides good insight for the determination of stress and deflection, with different parameters.
Application architecture and typical cases of big data technology in health management of civil aircraft system
Authors: Zhaobing Wang , Yi Wang , Shimeng Cui
Published: March 2019

Under the background of the big data era, the concept and technology of civil aircraft health management have been continuously innovated. This paper investigates the progress of health management technologies of mainstream manufacturers and airlines. Based on the analysis of operational data, this paper proposes a big data platform architecture for civil health management applications. Besides, the case of applying QAR data for prediction is introduced in the typical fault of air conditioning system, and the effectiveness of AR model in short-term trend prediction is verified.
Mathematical modeling and vibration simulation of an orbital sander
Authors: Shi Lingjian , Sun Beibei
Published: March 2019

Numerous epidemiological studies have shown that operators who use hand-held power tools are prone to develop hand-arm vibration syndrome. Therefore, it is necessary to reduce the tool vibrations to protect the worker’s health. This research focuses on the dynamic modeling and the vibration simulation of orbital sanders which are commonly used in industrial sectors. The mathematic model with eighteen degrees-of-freedom (DOF) of this machine is established based upon the Lagrange equation. The experiments are also conducted to test vibrations at the top of the housing where the operators hold the machine. The simulated results are found in good coincidence with the experimental results, and the errors between the experimental results and the simulated values are in acceptable range, which demonstrates the mathematic model in this paper is accurate.
Adomian’s decomposition method to modeling power functionally graded thermoelastic materials in heat transfer and thermal stress analysis
Authors: Youssef Hamdy M. , Al-Lehaibi Eman A. N.
Published: March 2019

This work deals with an iteration method for numerical solving the problem of one-dimensional coupled thermoelasticity under given boundary conditions. This iteration based on the Adomian’s decomposition method. All the material properties have been considered variable on position with a power law. The numerical results have been calculated for different cases of the gradient parameter and the gradient index. The numerical results have been shown in figures. The gradient parameter and the gradient index have significant effects on the temperature increment, the strain, the stress, and the displacement.
Modelling on vibration of skew plate with thickness and temperature variation
Authors: Bhardwaj Reeta , Mani Naveen
Published: March 2019

The present model describes the vibrational analysis of skew (parallelogram) plate made up of non-homogeneous material with variable thickness and temperature on clamped edges. One dimensional thickness and two-dimensional temperature variation is taken into consideration. The non-homogeneity of the plate varies circular in one dimension. The governing differential equation of motion for vibration analysis is solved by using Rayleigh Ritz technique and time period is calculated for the combination of different variation of plate parameters. The obtained results are presented in tabular form.
Vibration of rectangle plate with variable density and Poisson’s ratio
Authors: Sharma Amit , Kumar Vijay , Bhardwaj Reeta
Published: March 2019

The effect of variation in density and Poisson’s ratio is examined, on the vibration of rectangle plate with linear variable thickness. Bi parabolic temperature effect on the plate is also studied and vibrational modes of rectangular plate is calculated by using Rayleigh Ritz method. Authors also compared the present finding with the published results.
Analysis on the vibration modes of the electric vehicle motor stator
Authors: Li HuiBin , Zhang Da , Xu PeiYun , Cao Cheng , Hu DongMei , Yan XiaoJun , Song Zhihuan , Hu Zhihong
Published: March 2019

The lightweight design of the electric vehicle motor brought about more serious vibration and noise problem of the motor. An accurate modal calculation was the basis for the study of the vibration and noise characteristics of the electric vehicle motor. The finite element method was used to perform the modal simulation of the PMSM. Through the reasonable simplification and equivalence of the motor stator model, the first 7 orders natural frequencies and corresponding modes of the motor stator under the free state were calculated. After that, the accuracy of the finite element model was verified by the hammering modal experiment of the prototype. Furthermore, the above results will provide the theoretical basis for the electric vehicle motor’s vibration control and NVH improvement.
Application of roughing filter to pre-treat 1,000 NTU raw water for slow sand filter
Authors: Hashimoto Yuichi , Takashima Hiroshi , Jayamohan Somasundaram
Published: March 2019

It was confirmed experimentally that a Roughing Filter (RF) is effective as a pre-treatment system for Slow Sand Filter (SSF) with coagulant dosing and mixing with raw water. This RF system can pre-treat high turbidity raw water (1,000 NTU) to generate low turbidity (10 NTU) pre-treated water for SSF treatment. In the experiment, the types of filter media, height of the filter media, filtration rate and coagulant dosing were varied and the characteristics of each item were evaluated and the design guidelines were formulated. Water Treatment Plants (WTPs) consisting of pre-treatment with RF followed by SSF to treat river water were designed and constructed in Myanmar based on the design guidelines, and the operational performance was confirmed as effective to generate treated water with a turbidity under 5 NTU, which is in compliance with the WHO guideline despite the rather short working period of about one year. Sand scraping of SSF at a frequency of about once in every one to two months was implemented to maintain the design filtration rate.
Therapeutic Prospects in Preeclampsia - A Mini-Review
Authors: Das N.S. , Dheen S.T. , Ling E.A. , Bay B.H. , Srinivasan D.K.
Published: March 2019

Background:

Preeclapmsia (PE) is characterized by early onset symptoms such as
elevated blood pressure, proteinuria and edema in the pregnant woman, and may result in seizures
in the affected female. Currently, there are no therapeutic drugs available to treat this
condition, but there are interventions to regulate the symptoms based on the gestational period
of the fetus, although the largely favored option is delivery of the fetus and placenta.

Objective:

A search for biomolecules associated with PE was conducted so as to identify diagnostic
markers and therapeutic leads.

Results:

The literature search resulted in the identification of biomolecules such as Corin and
Placental Protein 13 (PP13), among others that are associated with PE. Thereby, giving an
insight into the various mechanistic pathways involved in the causation of PE. However, it is
also evident that PE cannot be solely attributed to any single mechanism but is due to an interplay
of different factors that have led to the development of this disease condition.

Conclusion:

The identified biomarkers would ultimately help in understanding this complex
disease and perhaps lead to the discovery of potential effective molecular targets for clinical
trials, thereby providing a valuable therapeutic option for affected pregnant women.
Recent Advances of In-Silico Modeling of Potent Antagonists for the Adenosine Receptors
Authors: Samanta Pabitra Narayan , Kar Supratik , Leszczynski Jerzy
Published: March 2019

The rapid advancement of computer architectures and development of mathematical algorithms offer a
unique opportunity to leverage the simulation of macromolecular systems at physiologically relevant timescales.
Herein, we discuss the impact of diverse structure-based and ligand-based molecular modeling techniques in
designing potent and selective antagonists against each adenosine receptor (AR) subtype that constitutes multitude
of drug targets. The efficiency and robustness of high-throughput empirical scoring function-based approaches
for hit discovery and lead optimization in the AR family are assessed with the help of illustrative examples
that have led to nanomolar to sub-micromolar inhibition activities. Recent progress in computer-aided drug
discovery through homology modeling, quantitative structure-activity relation, pharmacophore models, and molecular
docking coupled with more accurate free energy calculation methods are reported and critically analyzed
within the framework of structure-based virtual screening of AR antagonists. Later, the potency and applicability
of integrated molecular dynamics (MD) methods are addressed in the context of diligent inspection of intricated
AR-antagonist binding processes. MD simulations are exposed to be competent for studying the role of the membrane
as well as the receptor flexibility toward the precise evaluation of the biological activities of antagonistbound
AR complexes such as ligand binding modes, inhibition affinity, and associated thermodynamic and kinetic
parameters.
Synthesis, Structural Characterization, Molecular Modeling and DNA Binding Ability of CoII, NiII, CuII, ZnII, PdII and CdII Complexes of Benzocycloheptenone Thiosemicarbazone Ligand
Authors: El-Ghamry Hoda A. , Gaber Mohamed , Farghaly Thoraya A.
Published: March 2019

Background & Objective:

Six novel complexes of transition metal namely,
[CoLCl2(H2O)2]0.5H2O, [NiLCl2(H2O)2]0.5H2O, [CuLCl2]0.5H2O, [ZnLCl2], [PdLCl2]H2O and
[CdLCl2]H2O, where L is benzocycloheptenone thiosemicarbazone ligand, have been obtained. The
confirmation of the structures of the obtained metal chelates depends on the different spectral and
physicochemical techniques including CHN analysis, infrared spectra, molar conductivity measurement,
UV-vis, thermogravimetric analysis and magnetic moment. The infrared spectral results ascertained
that the ligand behaved as neutral bidentate connecting the metal centers via N and S atoms of
C=N and C=S groups, respectively.

Methods:

The UV-Vis, molar conductivity and magnetic susceptibility results implied that the geometrical
structures of the metal chelates are octahedral for Co(II) & Ni(II) complexes, tetrahedral for
Zn(II) & Cd(II) complexes and square planar for Cu(II) & Pd(II) complexes which have been confirmed
by molecular modeling studies.

Conclusion:

Moreover, the mode of interaction between some chosen metal complexes towards SSDNA
has been thoughtful by UV-Vis spectra and viscosity measurements. The value of the intrinsic
binding constant (Kb) for the examined compounds has been found to be lower than the binding affinity
of the classical intercalator ethedium bromide. Also, the viscosity measurements of the complexes
proved that they bind to DNA, most likely, by a non-intercalative mode like H-bonding or electrostatic
interactions.
Dihydroartemisinin and its Analogs: A New Class of Antitubercular Agents
Authors: Kalani Komal , Chaturvedi Vinita , Trivedi Priyanka , Tondon Sudeep , Srivastava Santosh Kumar
Published: March 2019

Background:

Tuberculosis is one of the leading causes of mortality worldwide. Resistance against
the frontline anti-tubercular drugs has worsened the already alarming situation, which requires intensive drug
discovery to develop new, more effective, affordable and accessible anti-tubercular agents possessing novel
modes of action.

Objective:

Chemical transformation of dihydroartemisinin for anti-tubercular lead optimization.

Methods:

Dihydroartemisinin, a metabolite of artemisinin was chemically converted into eight acyl derivatives
and were evaluated for anti-tubercular potential against H37Rv virulent strain of Mycobacterium tuberculosis by
agar-based proportion assay. Further, synergistic activity of 12-O-m-anisoyl dihydroartemisinin was also studied
with the front-line anti-TB drugs, isoniazid and rifampicin.

Results:

The results showed that all the derivatives were active but out of eight, 12-O-m-anisoyl dihydroartemisinin
and 12-O-p-anisoyl dihydroartemisinin were significantly active (MIC 25.0 µg/mL). In synergistic activity
evaluation, the 12-O-m-anisoyl dihydroartemisinin derivative showed reduction in MIC (by 1/8th, i.e. 3.12
µg/mL and that of rifampicin by ¼th, i.e. 0.05 µg/mL) with the front-line anti-TB drug, rifampicin. The sumfractional
inhibitory concentration (Σ FIC) was 0.375.

Conclusion:

These results suggested a synergistic effect of the 12-O-m-anisoyl dihydroartemisinin with rifampicin
and established its base for the development of anti-tubercular agents from an in-expensive and non-toxic
natural product. To the best of our knowledge this is the first ever report on the anti-tubercular potential of
dihydroartemisinin and its derivatives.
Quantum Molecular Dynamics, Topological, Group Theoretical and Graph Theoretical Studies of Protein-Protein Interactions
Authors: Balasubramanian Krishnan , Gupta Satya P.
Published: March 2019

Background:

Protein-protein interactions (PPIs) are becoming increasingly important as PPIs form the basis of multiple aggregation-related diseases such as cancer, Creutzfeldt-Jakob, and Alzheimer’s diseases. This mini-review presents hybrid quantum molecular dynamics, quantum chemical, topological, group theoretical, graph theoretical, and docking studies of PPIs. We also show how these theoretical studies facilitate the discovery of some PPI inhibitors of therapeutic importance.

Objective:

The objective of this review is to present hybrid quantum molecular dynamics, quantum chemical, topological, group theoretical, graph theoretical, and docking studies of PPIs. We also show how these theoretical studies enable the discovery of some PPI inhibitors of therapeutic importance.

Methods:

This article presents a detailed survey of hybrid quantum dynamics that combines classical and quantum MD for PPIs. The article also surveys various developments pertinent to topological, graph theoretical, group theoretical and docking studies of PPIs and highlight how the methods facilitate the discovery of some PPI inhibitors of therapeutic importance.

Results:

It is shown that it is important to include higher-level quantum chemical computations for accurate computations of free energies and electrostatics of PPIs and Drugs with PPIs, and thus techniques that combine classical MD tools with quantum MD are preferred choices. Topological, graph theoretical and group theoretical techniques are shown to be important in studying large network of PPIs comprised of over 100,000 proteins where quantum chemical and other techniques are not feasible. Hence, multiple techniques are needed for PPIs.

Conclusion:

Drug discovery and our understanding of complex PPIs require multifaceted techniques that involve several disciplines such as quantum chemistry, topology, graph theory, knot theory and group theory, thus demonstrating a compelling need for a multi-disciplinary approach to the problem.
Mechanisms of Antimicrobial Resistance (AMR) and Alternative Approaches to Overcome AMR
Authors: Moo Chew-Li , Yang Shun-Kai , Yusoff Khatijah , Ajat Mokrish , Thomas Warren , Abushelaibi Aisha , Lim Swee-Hua-Erin , Lai Kok-Song
Published: March 2019

Antimicrobials are useful compounds intended to eradicate or stop the growth of harmful
microorganisms. The sustained increase in the rates of antimicrobial resistance (AMR) worldwide
is worrying and poses a major public health threat. The development of new antimicrobial
agents is one of the critical approaches to overcome AMR. However, in the race towards developing
alternative approaches to combat AMR, it appears that the scientific community is falling
behind when pitched against the evolutionary capacity of multi-drug resistant (MDR) bacteria. Although
the “pioneering strategy” of discovering completely new drugs is a rational approach, the time
and effort taken are considerable, the process of drug development could instead be expedited if efforts
were concentrated on enhancing the efficacy of existing antimicrobials through: combination
therapies; bacteriophage therapy; antimicrobial adjuvants therapy or the application of
nanotechnology. This review will briefly detail the causes and mechanisms of AMR as background,
and then provide insights into a novel, future emerging or evolving strategies that are currently being
evaluated and which may be developed in the future to tackle the progression of AMR.