bluuebunny/crossref_metadata_2025 huggingface dataset:
Longitudinal Study Depicting Differences in Complementary Feeding and Anthropometric Parameters in Late Preterm Infants up to 2 Years of Age
Authors: Gómez-Martín María , Herrero-Morín David , Solís Gonzalo , Suarez Marta , Fernández Nuria , Arboleya Silvia , Gueimonde Miguel , González Sonia
Published: March 2021

Ensuring the nutritional demands of preterm (PT) infants during complementary feeding could contribute significantly to the infants’ long-term health and development. However, the dietary guidelines for complementary feeding in PT are scarce. Thus, describing dietary intake and identifying nutritional targets for these infants could be of great interest. The aim of this study is to assess the food intake and anthropometric parameters in a Mediterranean infant cohort from 6 to 24 months and to identify nutritional targets especially focused on late preterm infants. This is a longitudinal prospective study analyzing information from administered questionnaires about general characteristics and food frequency consumption in 115 infants (20 PT (32 to 36 gestational weeks), 95 full-term (FT)) at 6, 12 and 24 months of age. Results show that the differences in the prevalence of underweight observed in PT infants vs. FT infants are maintained for up to 6 months of age but disappear at 12 and 24 months. The age of inclusion of new foods and the average intake of the main food groups was not different from that of FTs. Although protein intake at 6 months was directly correlated with weight gain and growth in FT, these associations were not observed in PT. At the nutritional level, the low intake of vitamin D in preterm infants is noteworthy. These findings may be useful when designing new intervention strategies for this population group.
Does Examining the Childhood Food Experiences Help to Better Understand Food Choices in Adulthood?
Authors: Małachowska Aleksandra , Jeżewska-Zychowicz Marzena
Published: March 2021

Impact of parental feeding practices on children’s eating behaviors is well-documented in the literature. Nevertheless, little is known about how many of these behaviors might persist into adulthood. There is a lack of a tool measuring childhood feeding experiences recollected by adults, while the Comprehensive Feeding Practices Questionnaire (CFPQ) is used to measure parental feeding practices applied towards children. The aim of the study was to adapt the CFPQ to measure adults’ recollections of their childhood (5–10 years old) feeding experiences, to examine its discriminant validity and then to assess if these practices are related to adults’ food choices. In 2020, the modified version of CFPQ (mCFPQ) and questions on current food consumption were administered in a group of 500 adults twice over a two-week interval. The analysis included 443 participants whose questionnaires were correctly completed in both stages of the study. The Q-sorting procedure was used to test for discriminant validity of the questionnaire, i.e., confirmatory and exploratory factor analysis (EFA), Cronbach’s alpha, correlations coefficients, and the analysis of the differences between groups according to the intake of certain food products. Test–retest reliability was examined by calculating interclass correlation coefficients (ICC) for each obtained factor. As a result of EFA, five subscales were identified: “Restrictions”, “Healthy Eating Guidance”, “Pressure and Food Reward”, “Monitoring”, and “Child Control”. Items from these subscales created a new tool—Adults’ Memories of Feeding in Childhood (AMoFiC). Test for internal consistency, factor correlations, and discriminant validity proved satisfactory psychometric parameters of AMoFiC. “Pressure and Food Reward” and “Child Control” were associated with higher intake of sweets and salty snacks, whereas “Healthy Eating Guidance”, “Monitoring”, and “Restrictions” were associated with higher consumption of fresh fruits and vegetables. Despite the fact that the AMoFiC questionnaire requires further research, the findings of the study might be of practical use in counseling addressed to the parents.
The DASH Diet and Cardiometabolic Health and Chronic Kidney Disease: A Narrative Review of the Evidence in East Asian Countries
Authors: Song Yazhen , Lobene Andrea J. , Wang Yanfang , Hill Gallant Kathleen M.
Published: March 2021

The rising incidence of cardiometabolic diseases and chronic kidney disease (CKD) is a leading public health problem in East Asia. Diet is an important modifiable risk factor; thus, adopting a healthy diet such as the Dietary Approaches to Stop Hypertension (DASH) diet may help combat these chronic diseases. The DASH diet was originally developed in a U.S. population, and East Asia is demographically and culturally different from the U.S. Therefore, it is important to examine the evidence regarding the DASH diet and chronic disease in this unique population. This narrative review summarizes the evidence on the DASH diet and cardiometabolic health and CKD in East Asia. Culturally-modified DASH diets have been developed in some East Asian countries. Studies suggest the DASH diet is effective at lowering blood pressure in this population, though the long-term benefits remain unclear. Evidence also suggests the DASH diet may reduce the risk of type 2 diabetes and metabolic syndrome. Further research indicates the DASH diet and its components may reduce CKD risk. However, recommending the DASH diet in those who already have CKD is controversial, as it conflicts with current CKD dietary guidelines, especially in advanced CKD. Notably, current intakes in the general population differ from the DASH dietary pattern, suggesting public health efforts would be needed to encourage adoption of the DASH diet.
Oat Polar Lipids Improve Cardiometabolic-Related Markers after Breakfast and a Subsequent Standardized Lunch: A Randomized Crossover Study in Healthy Young Adults
Authors: Hossain Mohammad Mukul , Tovar Juscelino , Cloetens Lieselotte , Florido Maria T. Soria , Petersson Karin , Prothon Frederic , Nilsson Anne
Published: March 2021

It has been suggested that intake of polar lipids may beneficially modulate various metabolic variables. The purpose of this study was to evaluate the effect of oat polar lipids on postprandial and second meal glycemic regulation, blood lipids, gastrointestinal hormones, and subjective appetite-related variables in healthy humans. In a randomized design, twenty healthy subjects ingested four liquid cereal-based test beverages (42 g of available carbohydrates) containing: i. 30 g of oat oil with a low concentration (4%) of polar lipids (PLL), ii. 30 g of oat oil containing a high concentration (40%) of polar lipids (PLH), iii. 30 g of rapeseed oil (RSO), and iv. no added lipids (NL). The products were served as breakfast meals followed by a standardized lunch. Test variables were measured at fasting and during 3 h after breakfast and two additional hours following a standardized lunch. PLH reduced glucose and insulin responses after breakfast (0–120 min) compared to RSO, and after lunch (210–330 min) compared to RSO and PLL (p < 0.05). Compared to RSO, PLH resulted in increased concentrations of the gut hormones GLP-1 and PYY after the standardized lunch (p < 0.05). The results suggest that oat polar lipids have potential nutraceutical properties by modulating acute and second meal postprandial metabolic responses.
Modification of the Lipid Profile of the Initial Oral Biofilm In Situ Using Linseed Oil as Mouthwash
Authors: Kensche Anna , Reich Marco , Hannig Christian , Kümmerer Klaus , Hannig Matthias
Published: March 2021

Lipids are of interest for the targeted modification of oral bioadhesion processes. Therefore, the sustainable effects of linseed oil on the composition and ultrastructure of the in situ pellicle were investigated. Unlike saliva, linseed oil contains linolenic acid (18:3), which served as a marker for lipid accumulation. Individual splints with bovine enamel slabs were worn by five subjects. After 1 min of pellicle formation, rinses were performed with linseed oil for 10 min, and the slabs’ oral exposure was continued for up to 2 or 8 h. Gas chromatography coupled with electron impact ionization mass spectrometry (GC-EI/MS) was used to characterize the fatty acid composition of the pellicle samples. Transmission electron microscopy was performed to analyze the ultrastructure. Extensive accumulation of linolenic acid was recorded in the samples of all subjects 2 h after the rinse and considerable amounts persisted after 8 h. The ultrastructure of the 2 h pellicle was less electron-dense and contained lipid vesicles when compared with controls. After 8 h, no apparent ultrastructural effects were visible. Linolenic acid is an excellent marker for the investigation of fatty acid accumulation in the pellicle. New preventive strategies could benefit from the accumulation of lipid components in the pellicle.
The Relationship between Restrained Eating, Body Image, and Dietary Intake among University Students in China: A Cross-Sectional Study
Authors: Yong Cuiting , Liu Hanmei , Yang Qiping , Luo Jing , Ouyang Yufeng , Sun Minghui , Xi Yue , Xiang Caihong , Lin Qian
Published: March 2021

This study aims to explore the association between restrained eating, body image, and dietary intake among Chinese college students. This cross-sectional study included 1301 college students at two universities in Hunan Province. Electronic questionnaires were used to collect information including students’ demographic characteristics, restrained eating, perception of body weight, body satisfaction, and dietary intake. Anthropometric measurements were collected to calculate body mass index (BMI). The prevalence of high restrained eating was 52.8%. Students who were dissatisfied with their bodies or overestimated their body weight showed a higher tendency toward high restrained eating (p < 0.05). Students with high restrained eating tended to eat fruits and eggs more frequently, while the frequency of eating domestic animals and poultry, sugar-sweetened beverages, and fast food were the opposite. Moreover, high restrained eating was a risk factor for low dietary diversity (odds ratio (OR) = 1.384, 95% confidence interval: 1.002~1.912). The high incidence of restrained eating among Chinese college students and its energy-restricted diets that may lead to possible health implications require attention. Further studies are needed to investigate the characteristics of college students’ restrained eating to tailor appropriate interventions for forming positive body images and promoting healthy eating behaviors, thus, improving dietary quality.
Role of HO-1 against Saturated Fatty Acid-Induced Oxidative Stress in Hepatocytes
Authors: Ogino Noriyoshi , Miyagawa Koichiro , Nagaoka Kenjiro , Matsuura-Harada Yuki , Ogino Shihona , Kusanaga Masashi , Oe Shinji , Honma Yuichi , Harada Masaru , Eitoku Masamitsu , Suganuma Narufumi , Ogino Keiki
Published: March 2021

Increased circulating levels of free fatty acids, especially saturated ones, are involved in disease progression in the non-alcoholic fatty liver. Although the mechanism of saturated fatty acid-induced toxicity in the liver is not fully understood, oxidative stress may be deeply involved. We examined the effect of increased palmitic acid, the most common saturated fatty acid in the blood, on the liver of BALB/c mice via tail vein injection with palmitate. After 24 h, among several anti-oxidative stress response genes, only heme oxygenase-1 (HO-1) was significantly upregulated in palmitate-injected mice compared with that in vehicle-injected mice. Elevation of HO-1 mRNA was also observed in the fatty liver of high-fat-diet-fed mice. To further investigate the role of HO-1 on palmitic acid-induced oxidative stress, in vitro experiments were performed to expose palmitate to HepG2 cells. SiRNA-mediated knockdown of HO-1 significantly increased the oxidative stress induced by palmitate, whereas pre-treatment with SnCl2, a well-known HO-1 inducer, significantly decreased it. Moreover, SB203580, a selective p38 inhibitor, reduced HO-1 mRNA expression and increased palmitate-induced oxidative stress in HepG2 cells. These results suggest that the HO-1-mediated anti-oxidative stress compensatory reaction plays an essential role against saturated fatty acid-induced lipotoxicity in the liver.
Effectiveness of Folic Acid Supplementation Recommendations among Polish Female Students from the Podkarpackie Region
Authors: Zadarko-Domaradzka Maria , Kruszyńska Ewa , Zadarko Emilian
Published: March 2021

Adequate folic acid supplementation during the preconception period is an important element in the primary prevention of neural tube defects (NTDs). This study aims to study the effectiveness of folic acid supplementation recommendations among women of childbearing age, and to assess and characterise their awareness about this public health measure. The cross-sectional study included women (N = 1285) aged 22.27 ± 4.6 years old on average. Some of the results were obtained on a subgroup of women (N = 1127) aged 21.0 ± 2.1. This study was performed using a questionnaire. The analysis was performed with the use of a logistic regression model, chi-square test for independence and odds ratio (OR). According to the results, only 13.9% of women supplement folic acid, and 65.3% of them do so daily. A total of 91.1% of the respondents were not aware of its recommended dose and 43% did not know the role it plays in the human body. Among women who do not currently supplement folic acid (N = 1052), 52.4% declared doing so while planning their pregnancy. Women’s awareness about the role of folic acid in NTD prevention (OR = 4.58) and the information they got from physicians (OR = 1.68) are key factors that increased the odds of the women taking folic acid before pregnancy. There is therefore a need for more information and education campaigns to raise awareness about folic acid.
Proteomic Analysis of Mycelial Exudates of Ustilaginoidea virens
Authors: Wang Haining , Yang Xiaohe , Wei Songhong , Wang Yan
Published: March 2021

Rice false smut (RFS) disease, which is caused by Ustilaginoidea virens, has been widespread all over the world in recent years, causing irreversible losses. Under artificial culture conditions, exudates will appear on colonies of U. virens during the growth of the hyphae. Exudation of droplets is a common feature in many fungi, but the functions of exudates are undetermined. As the executors of life functions, proteins can intuitively reflect the functions of exudates. Shotgun proteomics were used in this study. A total of 650 proteins were identified in the exudate of U. virens, and the raw data were made available via ProteomeXchange with the identifier PXD019861. There were 57 subcategories and 167 pathways annotated with Gene Ontology (GO) classification and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, respectively. Through protein–protein interaction (PPI) network analysis, it was found that 20 proteins participated in the biosynthesis of secondary metabolites. Two separate PPI analyses were performed for carbon metabolism and microbial metabolism in diverse environments. After comparing and annotating the functions of proteins of the exudate, it was speculated that the exudate was involved in the construction and remodeling of the fungal cell wall. Pathogenicity, sporulation, and antioxidant effects might all be affected by the exudate.
Development of a Colloidal Gold Immunochromatographic Assay for Duck Enteritis Virus Detection Using Monoclonal Antibodies
Authors: Liu Fengli , Cao Yanxin , Yan Maokai , Sun Mengxu , Zhang Qingshui , Wang Jun , Fu Guanghua , Liu Rongchang , Huang Yu , Su Jingliang
Published: March 2021

Duck viral enteritis is a highly contagious and fatal disease of commercial waterfowl flocks. The disease occurs sporadically or epizootically in mainland China due to insufficient vaccinations. Early and rapid diagnosis is important for preventive intervention and the control of epizootic events in clinical settings. In this study, we generated two monoclonal antibodies (MAbs) that specifically recognized the duck enteritis virus (DEV) envelope glycoprotein B and tegument protein UL47, respectively. Using these MAbs, a colloidal gold-based immunochromatographic assay (ICA) was developed for the efficient detection of DEV antigens within 15 min. Our results showed that the detection limit of the developed ICA strip was 2.52 × 103 TCID50/mL for the virus infected cell culture suspension with no cross-reactivity with other pathogenic viruses commonly encountered in commercially raised waterfowl. Using samples from experimentally infected ducks, we demonstrated that the ICA detected the virus in cloacal swab samples on day three post-infection, demonstrating an 80% concordance with the PCR. For tissue homogenates from ducks succumbing to infection, the detection sensitivity was 100%. The efficient and specific detection by this ICA test provides a valuable, convenient, easy to use and rapid diagnostic tool for DVE under both laboratory and field conditions.
Respiratory Manifestations in Systemic Lupus Erythematosus
Authors: Di Bartolomeo Salvatore , Alunno Alessia , Carubbi Francesco
Published: March 2021

Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease characterized by a wide spectrum of clinical manifestations. The respiratory system can be involved in up to 50–70% of patients and be the presenting manifestation of the disease in 4–5% of cases. Every part of the respiratory part can be involved, and the severity can vary from mild self-limiting to life threatening forms. Respiratory involvement can be primary (caused by SLE itself) or secondary (e.g., infections or drug toxicity), acute or chronic. The course, treatment and prognosis vary greatly depending on the specific pattern of the disease. This review article aims at providing an overview of respiratory manifestations in SLE along with an update about therapeutic approaches including novel biologic therapies.
Species Differences in Microsomal Metabolism of Xanthine-Derived A1 Adenosine Receptor Ligands
Authors: Schneider Daniela , Bier Dirk , Holschbach Marcus , Bauer Andreas , Neumaier Bernd
Published: March 2021

Tracer development for positron emission tomography (PET) requires thorough evaluation of pharmacokinetics, metabolism, and dosimetry of candidate radioligands in preclinical animal studies. Since variations in pharmacokinetics and metabolism of a compound occur in different species, careful selection of a suitable model species is mandatory to obtain valid data. This study focuses on species differences in the in vitro metabolism of three xanthine-derived ligands for the A1 adenosine receptor (A1AR), which, in their 18F-labeled form, can be used to image A1AR via PET. In vitro intrinsic clearance and metabolite profiles of 8-cyclopentyl-3-(3-fluoropropyl)-1-propylxanthine (CPFPX), an established A1AR-ligand, and two novel analogs, 8-cyclobutyl-3-(3-fluoropropyl)-1-propylxanthine (CBX) and 3-(3-fluoropropyl)-8-(1-methylcyclobutyl)-1-propylxanthine (MCBX), were determined in liver microsomes from humans and preclinical animal species. Molecular mechanisms leading to significant differences between human and animal metabolite profiles were also examined. The results revealed significant species differences regarding qualitative and quantitative aspects of microsomal metabolism. None of the tested animal species fully matched human microsomal metabolism of the three A1AR ligands. In conclusion, preclinical evaluation of xanthine-derived A1AR ligands should employ at least two animal species, preferably rodent and dog, to predict in vivo behavior in humans. Surprisingly, rhesus macaques appear unsuitable due to large differences in metabolic activity towards the test compounds.
Chondroitin Sulfate-Modified Liposomes for Targeted Co-Delivery of Doxorubicin and Retinoic Acid to Suppress Breast Cancer Lung Metastasis
Authors: Zhang Zhiwei , Ma Lixin , Luo Jingwen
Published: March 2021

Breast cancer treatment remains challenging due to high levels of cell metastasis. Chemotherapy drug combinations can inhibit both tumor growth in situ and metastasis to distant organs. Therefore, here, we developed chondroitin sulfate liposomes (CSLs) as a carrier for the co-delivery of retinoic acid (RA) and doxorubicin (DOX) and examined their efficiency in suppressing lung metastasis of breast cancer. CSLs were prepared using CS–deoxycholic acid conjugates and found to encapsulate both RA and DOX via hydrophobic and hydrophilic interactions. The resulting DOX+RA-CSLs were uniformly spherical and showed good serum stability and encapsulation efficiency of 98.7% ± 1.3% for RA and 90.8% ± 2.9% for DOX. Pharmacodynamic experiments in vitro and in vivo also revealed that DOX+RA-CSLs had better anticancer and anti-metastatic activity than CS-free liposomes, single drug-loaded liposomes, and free drug solutions at the same dose (2 mg/kg DOX or RA). Our results suggest that this liposomal delivery system can effectively suppress lung metastasis of breast cancer.
Cyclodextrins in Antiviral Therapeutics and Vaccines
Authors: Braga Susana , Barbosa Jéssica , Santos Nádia , El-Saleh Firas , Paz Filipe
Published: March 2021

The present review describes the various roles of cyclodextrins (CDs) in vaccines against viruses and in antiviral therapeutics. The first section describes the most commonly studied application of cyclodextrins—solubilisation and stabilisation of antiviral drugs; some examples also refer to their beneficial taste-masking activity. The second part of the review describes the role of cyclodextrins in antiviral vaccine development and stabilisation, where they are employed as adjuvants and cryopreserving agents. In addition, cyclodextrin-based polymers as delivery systems for mRNA are currently under development. Lastly, the use of cyclodextrins as pharmaceutical active ingredients for the treatment of viral infections is explored. This new field of application is still taking its first steps. Nevertheless, promising results from the use of cyclodextrins as agents to treat other pathologies are encouraging. We present potential applications of the results reported in the literature and highlight the products that are already available on the market.
Multi-Analytical Framework to Assess the In Vitro Swallowability of Solid Oral Dosage Forms Targeting Patient Acceptability and Adherence
Authors: Ershad Abdul Latif , Rajabi-Siahboomi Ali , Missaghi Shahrzad , Kirby Daniel , Mohammed Afzal Rahman
Published: March 2021

A lack of effective intervention in addressing patient non-adherence and the acceptability of solid oral dosage forms combined with the clinical consequences of swallowing problems in an ageing world population highlight the need for developing methods to study the swallowability of tablets. Due to the absence of suitable techniques, this study developed various in vitro analytical tools to assess physical properties governing the swallowing process of tablets by mimicking static and dynamic stages of time-independent oral transitioning events. Non-anatomical models with oral mucosa-mimicking surfaces were developed to assess the swallowability of tablets; an SLA 3D printed in vitro oral apparatus derived the coefficient of sliding friction and a friction sledge for a modified tensometer measured the shear adhesion profile. Film coat hydration and in vitro wettability was evaluated using a high-speed recording camera that provided quantitative measurements of micro-thickness changes, simulating static in vivo tablet–mucosa oral processing stages with artificial saliva. In order to ascertain the discriminatory power and validate the multianalytical framework, a range of commonly available tablet coating solutions and new compositions developed in our lab were comparatively evaluated according to a quantitative swallowability index that describes the mathematical relationship between the critical physical forces governing swallowability. This study showed that the absence of a film coat significantly impeded the ease of tablet gliding properties and formed chalky residues caused by immediate tablet surface erosion. Novel gelatin- and λ-carrageenan-based film coats exhibited an enhanced lubricity, lesser resistance to tangential motion, and reduced stickiness than polyvinyl alcohol (PVA)–PEG graft copolymer, hydroxypropyl methylcellulose (HPMC), and PVA-coated tablets; however, Opadry® EZ possessed the lowest friction–adhesion profile at 1.53 a.u., with the lowest work of adhesion profile at 1.28 J/mm2. For the first time, the in vitro analytical framework in this study provides a fast, cost-effective, and repeatable swallowability ranking method to screen the in vitro swallowability of solid oral medicines in an effort to aid formulators and the pharmaceutical industry to develop easy-to-swallow formulations.
Thermosensitive Gels Used to Improve Microneedle-Assisted Transdermal Delivery of Naltrexone
Authors: Tobin Kevin V. , Fiegel Jennifer , Brogden Nicole K.
Published: March 2021

Transdermal delivery of naltrexone (NTX) can be enhanced using microneedles, although micropores generated this way can reseal by 48 h in humans, which prevents further drug delivery from a formulation. Poloxamer 407 (P407) is a thermosensitive polymer that may extend microneedle-assisted NTX delivery time by creating an in situ gel depot in the skin. We characterized gelation temperature, drug release, and permeation of P407 gels containing 7% NTX-HCl. To investigate microneedle effects on NTX-HCl permeation, porcine skin was treated with microneedles (600 or 750 μm length), creating 50 or 100 micropores. The formulations were removed from the skin at 48 h to simulate the effect of micropores resealing in vivo, when drug delivery is blunted. Gelation temperature increased slightly with addition of NTX-HCl. In vitro NTX-HCl release from P407 formulations demonstrated first order release kinetics. Microneedle treatment enhanced NTX-HCl permeation both from aqueous solution controls and P407 gels. Steady-state flux was overall lower in the P407 conditions compared to the aqueous solution, though ratios of AUCs before and after gel removal demonstrate that P407 gels provide more sustained release even after gel removal. This may be beneficial for reducing the required application frequency of microneedles for ongoing treatment.
Preparation and Antifouling Property of Polyurethane Film Modified by PHMG and HA Using Layer-by-Layer Assembly
Authors: Yuan Huihui , Xue Chenli , Zhu Jiaqian , Yang Zhaogang , Lan Minbo
Published: March 2021

To reduce the possibility of bacterial infection and implant-related complications, surface modification on polyurethane (PU) film is an ideal solution to endow hydrophobic PU with antibacterial and antifouling properties. In this work, a variety of polyhexamethylene guanidine/ hyaluronic acid (PHMG/HA) multilayer films were self-assembled layer-by-layer on PU films using polyanions, carboxyl-activated HA, and polycations PHMG by controlling the concentration of these polyelectrolytes as well as the number of layers self-assembled. Attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) spectra, water contact angle (WCA), and A Atomic force microscope (AFM) of PU and modified PU films were studied. Protein adsorption and bacterial adhesion as well as the cytotoxicity against L929 of the film on selected PU-(PHMG/HA)5/5-5 were estimated. The results showed that PU-(PHMG/HA)5/5-5 had the best hydrophilicity among all the prepared films, possessing the lowest level of protein adsorption. Meanwhile, this film showed efficient broad-spectrum antibacterial performance as well as significant resistance of bacterial adhesion of more than a 99.9% drop for the selected bacteria. Moreover, almost no influence on cell viability of L929 enhanced the biocompatibility of film. Therefore, the modified PU films with admirable protein absorption resistance, antimicrobial performance, and biocompatibility would have promising applications in biomedical aspect.
Strain–Microstructure–Optoelectronic Inter-Relationship toward Engineering Mechano-Optoelectronic Conjugated Polymer Thin Films
Authors: Lee Youngmin , Mongare Alfred , Plant Aaron , Ryu Donghyeon
Published: March 2021

Mechano-optoelectronic (MO) behavior indicates changes in optoelectronic properties in response to the applied mechanical deformation. The MO behavior can be employed to monitor the mechanical deformation of a targeted system by tracing its optoelectronic properties. Poly(3-hexylthiophene) and phenyl-C61-butyric acid methyl ester (P3HT/PCBM) blend thin films exhibited changes in direct current under tensile strain. Although optoelectronic properties and photovoltaic performance of P3HT/PCBM blends have been studied extensively and intensively, research required for MO properties has a fundamental difference from previous research mostly for solar cells. In research for MO systems, a greater extent of changes in optoelectronic properties under mechanical deformation is favorable. Herein, previous research for optoelectronic properties and mechanical properties of conjugated polymers will be reviewed from a perspective on MO properties. The microstructure of a conjugated polymer thin film plays a pivotal role in its optoelectronic properties and mechanical properties. Key parameters involved in the microstructure of conjugated polymer thin films will be addressed. A scalable process is required to broaden applications of MO systems. Potential challenges in the fabrication of MO conjugated polymer thin films will be discussed. Finally, this review is envisioned to provide insight into the design and manufacturing of MO conjugated polymer thin films.
Holographic Recording Performance of Acrylate-Based Photopolymer under Different Preparation Conditions for Waveguide Display
Authors: Shen Zhongwen , Weng Yishi , Zhang Yuning , Wang Chuang , Liu Ao , Li Xiaohua
Published: March 2021

This work proposes a green light-sensitive acrylate-based photopolymer. The effects of the preparation conditions for the waveguide applied volume holographic gratings (VHGs) were experimentally investigated. The optimum preparation conditions for holographic recording were revealed. After optimization, the peak of VHG diffraction efficiency reached 99%, the diffractive wavelength bandwidth increased from 13 nm to 22 nm, and the corresponding RIM was 0.06. To prove the wide application prospect of the acrylate-based photopolymer in head-mounted augmented reality (AR) displays, green monochromatic volume holographic waveguides were fabricated. The display results showed that the prototype was able to achieve a 28° diagonal FOV and possessed a system luminance of 300 cd/m2.
Anticoagulant Activity of Cellulose Nanocrystals from Isora Plant Fibers Assembled on Cellulose and SiO2 Substrates via a Layer-by-Layer Approach
Authors: Mohan Tamilselvan , Chirayil Cintil Jose , Nagaraj Chandran , Bračič Matej , Steindorfer Tobias Alexander , Krupa Igor , Maadeed Mariam Al Ali Al , Kargl Rupert , Thomas Sabu , Stana Kleinschek Karin
Published: March 2021

In this study, we report the isolation of cellulose nanocrystals (CNCs) from Isora plant fibers by sulfuric acid hydrolysis and their assembly on hydrophilic cellulose and silicon-di-oxide (SiO2) surfaces via a layer-by-layer (LBL) deposition method. The isolated CNCs were monodispersed and exhibited a length of 200–300 nm and a diameter of 10–20 nm, a negative zetapotential (−34–39 mV) over a wide pH range, and high stability in water at various concentrations. The multi-layered structure, adsorbed mass, conformational changes, and anticoagulant activity of sequentially deposited anionic (sulfated) CNCs and cationic polyethyleneimine (PEI) on the surfaces of cellulose and SiO2 by LBL deposition were investigated using a quartz crystal microbalance technique. The organization and surface features (i.e., morphology, thickness, wettability) of CNCs adsorbed on the surfaces of PEI deposited at different ionic strengths (50–300 mM) of sodium chloride were analysed in detail by profilometry layer-thickness, atomic force microscopy and contact angle measurements. Compared to cellulose (control sample), the total coagulation time and plasma deposition were increased and decreased, respectively, for multilayers of PEI/CNCs. This study should provide new possibilities to fabricate and tailor the physicochemical properties of multilayer films from polysaccharide-based nanocrystals for various biomedical applications.
Properties of Starve-Fed Extrusion on a Material Containing a VHMWPE Fraction
Authors: Rathner Raffael , Tranchida Davide , Roland Wolfgang , Ruemer Franz , Buchmann Klaus , Amsüss Philipp , Steinbichler Georg
Published: March 2021

Single-screw extruders are usually operated with the screw fully filled (flood-fed mode) and not partially filled (starve-fed mode). These modes result in completely different processing characteristics, and although starve-fed mode has been shown to have significant advantages, such as improved mixing and melting performance, it is rarely used, and experimental studies are scarce. Here, we present extensive experimental research into starve-fed extrusion at feeding rates as low as 25%. We compared various operating parameters (e.g., residence time, pressure build-up, and melting performance) at various feeding rates and screw speeds. The results show a first insight into the performance of starve-fed extruders compared to flood-fed extruders. We explored starve-fed extrusion of a polyethylene material which contains a Very High Molecular Weight Polyethylene fraction (VHMWPE). VHMWPE offers several advantages in terms of mechanical properties, but its high viscosity renders common continuous melt processes, such as compression molding, ram extrusion and sintering, ineffective. This work shows that operating single-screw extruders in extreme starve-fed mode significantly increases residence time, melt temperature, and improves melting and that-in combination—this results in significant elongation of VHMWPE particles.
A Facile Solution Engineering of PEDOT:PSS-Coated Conductive Textiles for Wearable Heater Applications
Authors: Jin In Su , Lee Jea Uk , Jung Jae Woong
Published: March 2021

To enable highly conductive electronic textiles (E-textiles), we herein demonstrate a simple solution treatment of poly (3,4-ethylenedioxythiophene): poly (styrene sulfonate) (PEDOT:PSS)-coated textiles by dimethyl sulfoxide (DMSO) and methanol. The subsequent solution engineering of DMSO and methanol not only enhances crystallization of PEDOT chains but also the contact for PEDOT:PSS to the fibers. Additionally, the methanol dipping effectively removes the insulating PSS part from the conductive PEDOT chains, which contributes to subsequently reduced sheet resistance of less than 3 Ω/sq of the conductive textiles. Joule heating property of the highly conductive textiles achieves the maximum temperature with the temperature reaching 133 °C at a low applied voltage of 3 V within 20 s, which promises highly conductive E-textiles as multi-functional wearable heater applications.
Penetration of Hydrogen into Polymer Electrolyte Membrane for Fuel Cells by Quantum and Molecular Dynamics Simulations
Authors: Cha JinHyeok , Lee Wooju , Baek Jihye
Published: March 2021

The advent of the Hydrogen Society created great interest around hydrogen-based energy a decade ago, with several types of vehicles based on hydrogen fuel cells already being produced in the automotive sector. For highly efficient fuel cell systems, the control of hydrogen inside a polymer-based electrolyte membrane is crucial. In this study, we investigated the molecular behavior of hydrogen inside a polymer-based proton-exchange membrane, using quantum and molecular dynamics simulations. In particular, this study focused on the structural difference of the pendent-like side chain polymer, resulting in the penetration ratio of hydrogen into the membrane deriving from the penetration depth of the membrane’s thickness while keeping the simulation time constant. The results reveal that the penetration ratio of the polymer with a shorter side chain was higher than that with the longer side chain. This was justified via two perspectives; electrostatic and van der Waals molecular interactions, and the structural difference of the polymers resulting in the free volume and different behavior of the side chain. In conclusion, we found that a longer side chain is more trembling and acts as an obstruction, dominating the penetration of hydrogen inside the polymer membrane.
Toward Physicochemical and Rheological Characterization of Different Injectable Hyaluronic Acid Dermal Fillers Cross-Linked with Polyethylene Glycol Diglycidyl Ether
Authors: Zerbinati Nicola , Sommatis Sabrina , Maccario Cristina , Capillo Maria Chiara , Grimaldi Giulia , Alonci Giuseppe , Protasoni Marina , Rauso Raffaele , Mocchi Roberto
Published: March 2021

(1) Background: Injectable hyaluronic acid (HA) dermal fillers are used to restore volume, hydration and skin tone in aesthetic medicine. HA fillers differ from each other due to their cross-linking technologies, with the aim to increase mechanical and biological activities. One of the most recent and promising cross-linkers is polyethylene glycol diglycidyl ether (PEGDE), used by the company Matex Lab S.p.A., (Brindisi, Italy) to create the HA dermal filler PEGDE family. Over the last few years, several studies have been performed to investigate the biocompatibility and biodegradability of these formulations, but little information is available regarding their matrix structure, rheological and physicochemical properties related to their cross-linking technologies, the HA content or the degree of cross-linking. (2) Methods: Seven different injectable HA hydrogels were subjected to optical microscopic examination, cohesivity evaluation and rheological characterization in order to investigate their behavior. (3) Results: The analyzed cross-linked dermal fillers showed a fibrous “spiderweb-like” matrix structure, with each medical device presenting different and peculiar rheological features. Except for HA non cross-linked hydrogel 18 mg/mL, all showed an elastic and cohesive profile. (4) Conclusions: The comparative analysis with other literature works makes a preliminary characterization of these injectable medical devices possible.
Matching Rheology, Conductivity and Joule Effect in PU/CNT Nanocomposites
Authors: Sangroniz Leire , Landa Maite , Fernández Mercedes , Santamaria Antxon
Published: March 2021

We investigated polyurethane (PU)–carbon nanotube (CNT) nanocomposites (PU/CNT) in a range of concentrations from 1 to 8 wt% CNT as hot melt adhesives. We studied the thermal properties of the nanocomposites, which is relevant from an applied point of view. The phase angle plots versus complex modulus results revealed the existence of a maximum above a given CNT concentration. The intensity of the peak and associated relaxation time was analyzed with percolation theory, leading to a new method to determine the rheological percolation threshold. A lower threshold value was obtained from the electrical conductivity data, which was justified recalling that the hopping/tunnelling effect takes place in the nanocomposite, as stated by previous studies in the literature. Joule effect studies indicated that the heating effect was very significant, reaching temperature increases, ΔT, of 60 °C for low voltages. For the first time, the percolation equation was applied to the ΔT to obtain the corresponding threshold. Stimulus-responsive systems were conceived considering the correlation between the ΔT and the conductivity. The case of PU/CNT nanocomposites acting as hot melt adhesives that are welded/unglued by applying/removing an electrical voltage is presented.
Mechanical Properties of Epoxy Compounds Based on Bisphenol a Aged in Aqueous Environments
Authors: Rudawska Anna
Published: March 2021

(1) Background: The aim of the work is to determine the influence of selected aqueous environments of various types of liquids on the strength of adhesive compositions prepared from epoxy resin based on bisphenol A combined with two different curing agents: tritethylenetetramine and polyaminoamide C. (2) Methods: The cured epoxy adhesive compounds samples were seasoned in four aqueous environments of the liquid: rainwater, demineralized water, tap water, and a sweetened drink. Three variants of the aging time in the above-mentioned operating environments were adopted: one month, two months, and three months. After the specified maturing time, samples of epoxy adhesive compositions were subjected to the strength tests on the Zwick/Roell 150 testing machine, which is in accordance with ISO 604 standard, determining the compressive strength. (3) Results: On the basis of the obtained strength test results and their analysis, it was noticed, inter alia, that the strength of the epoxy compounds decreases with the aging time in all used aqueous environments. Moreover, in the case of both types of the epoxy compounds, the highest strength was achieved after aging in demineralized water.
What Is Rational and Irrational in Human Decision Making
Authors: Pothos Emmanuel M. , Waddup Oliver J. , Kouassi Prince , Yearsley James M.
Published: March 2021

There has been a growing trend to develop cognitive models based on the mathematics of quantum theory. A common theme in the motivation of such models has been findings which apparently challenge the applicability of classical formalisms, specifically ones based on classical probability theory. Classical probability theory has had a singularly important place in cognitive theory, because of its (in general) descriptive success but, more importantly, because in decision situations with low, equivalent stakes it offers a multiply justified normative standard. Quantum cognitive models have had a degree of descriptive success and proponents of such models have argued that they reveal new intuitions or insights regarding decisions in uncertain situations. However, can quantum cognitive models further benefit from normative justifications analogous to those for classical probability models? If the answer is yes, how can we determine the rational status of a decision, which may be consistent with quantum theory, but inconsistent with classical probability theory? In this paper, we review the proposal from Pothos, Busemeyer, Shiffrin, and Yearsley (2017), that quantum decision models benefit from normative justification based on the Dutch Book Theorem, in exactly the same way as models based on classical probability theory.
Introduction of Special Issue “Religion and Refugee: Interdisciplinary Discussions on Transformative Human-Divine Interactions”
Authors: Horstmann Alexander , Jung Jin-Heon
Published: March 2021

Mainstream works on refugees and religion have underlined the value that religion provides to émigrés [...]
Exclusive Monotheism and Sahagún’s Mission: The Problem of Universals in the First Book of the Florentine Codex
Authors: Sánchez-Perry Josefrayn
Published: March 2021

This article outlines the missionary methods of the Franciscan Bernardino de Sahagún, his interaction with Nahua communities in central Mexico, and the production of a text called the Florentine Codex. This article argues that the philosophical problem of universals, whether “common natures” existed and whether they existed across all cultures, influenced iconoclastic arguments about Nahua gods and idolatry. Focusing on the Florentine Codex Book 1 and its Appendix, containing a description of Nahua gods and their refutation, the article establishes how Sahagún and his team contended with the concept of universals as shaped by Nahua history and religion. This article presents the Florentine Codex Book 1 as a case study that points to larger patterns in the Christian religion, its need for mission, and its construal of true and false religion.
Transcripts of Unfulfillment: A Study of Sexual Dysfunction and Dissatisfaction among Malay-Muslim Women in Malaysia
Authors: Muhamad Rosediani , Horey Dell , Liamputtong Pranee , Low Wah Yun , Mohd Zulkifli Maryam , Sidi Hatta
Published: March 2021

The prevalence of female sexual dysfunction (FSD), or in everyday notion, sexual dissatisfaction, among Malay women remains high, denoting that there are several influences shaping their experience of sex within marriage. This qualitative study identified the perceived effects of social factors in the development of sexual dysfunction among Malay women. Engaging a phenomenological framework, 26 in-depth face-to-face interviews were conducted among married women from Peninsular Malaysia, based on their self-reporting of FSD symptoms. All sessions were audio-recorded and the data were transcribed verbatim and managed in the ATLAS.ti software before being analysed. The three themes that emerged—‘sex is taboo and culturally unacceptable’, ‘self-ignorance about sex’, and ‘lack of husband’s role in mutual sexual enjoyment’—suggest some influence of Islamic teachings and cultural conduct, as in Adat, on sexuality in society. However, a lack of knowledge and nonadherence to positive values and teachings around sexual satisfaction between men and women, as espoused through the Islamic religion, have affected woman’s sexual functions and coupling relationship even more significantly. The results of this qualitative study show that a formal, culturally sensitive, and comprehensive sex education programme incorporating both medical and Islamic knowledge may work to effectively reduce FSD.
Civil Religion or Nationalism? The National Day Celebrations in Norway
Authors: Botvar Pål Ketil
Published: March 2021

The Norwegian National Day (17 May, also referred to as Constitution Day) stands out as one of the most popular National Day celebrations in Europe. According to surveys, around seven out of every 10 Norwegians take part in a public celebration during this day. This means that the National Day potentially has an impact on the way people reflect upon national identity and its relationship to the Lutheran heritage. In this paper, I will focus on the role religion plays in the Norwegian National Day rituals. Researchers have described these rituals as both containing a significant religious element and being rather secularized. In this article, I discuss the extent to which the theoretical concepts civil religion and religious nationalism can help us understand the role of religion, or the absence of religion, in these rituals. Based on surveys of the general population, I analyze both indicators of civil religion and religious nationalism. The two phenomena are compared by looking at their relation to such items as patriotism, chauvinism, and xenophobia. The results show that civil religion explains participation in the National Day rituals better than religious nationalism.