bluuebunny/crossref_metadata_2025 huggingface dataset:
Expression and content of the LC3B protein in papillary thyroid cancer, relation with the clinical and morphological parameters
Authors: Ковалева Ирина , Спирина Людмила , Чижевская Светлана , Кондакова Ирина , Чойнзонов Евгений
Published: August 2022

Material and methods. The study included 65 patients with papillary thyroid cancer T1-4N0-1M0. The comparison group was represented by 39 patients with benign thyroid pathology (22 patients with follicular adenoma and 17 patients with nodular goiter). The expression of the LC3B protein was assessed using the real-time PCR method, and the protein content was assessed by the Western blotting method. The BRAF-V600E mutation was determined using the Real-time-PCR-BRAF-V600E reagent kit.
Results of the investigation. An increase in the expression and content of the LC3B protein was found in the papillary thyroid cancer in 2.7 and 3.15 times compared with patients with benign tumor pathology. Patients with tumor size T3-4N0-1M0 showed a 1.6-fold increase in the LC3B protein content compared with patients with T1-2N0M0. The defeat of regional lymph nodes in patients with PCa was associated with an increase in the expression and content of LC3B by 2.0 and 2.4 times, respectively, compared with patients without metastases. An increase in protein expression and content was revealed by 2.5 and 1.7 times, respectively, in patients with the presence of the thyroid capsule invasion compared with patients without invasion. At the same time, a high content of autophagy protein was shown in the classical variant of the tumor, where the indicator was 2.8 times higher than in the follicular subtype.
Conclusion. An increase in the expression and content of the LC3B protein in the papillary thyroid cancers was revealed. The activation of autophagy plays a decisive role in oncogenesis and in the invasive and metastatic potential formation. The autophagy activation was revealed in the classic variant of papillary thyroid cancer. The association of the BRAF-V600E mutation with the expression and content of the LC3B protein has not been shown.
Surgical treatment of metastases of medullary thyroid cancer in the liver
Authors: Исаев Павел , Полькин Вячеслав , Петров Леонид , Ильин Алексей , Панасейкин Юрий , Плугарь Алиса , Агабабян Татев , Исаева Аиша , Иванов Сергей , Каприн Андрей
Published: August 2022

An aim of this study is to analyze treatment results of 4 patients with metastatic lesions of medullary thyroid cancer (MTC) who underwent liver resection. Annually in Russian Federation 600 new cases of MTC are diagnosing (0.2 per 100,000 humans). According to literature, in half of them a distant metastasis will develop. Isolated liver lesions develop in up to 0,5%. Resection of MTC metastases perform in only a small number of patients. Thus, little is known about outcomes of such treatment.
Using the results of single-photon emission computed tomography with [99mTc]-MIBI at the stages of preoperative therapy in patients with breast cancer
Authors: Медведева Анна , Чернов Владимир , Зельчан Роман , Брагина Ольга , Рыбина Анастасия , Дорошенко Артем , Гарбуков Евгений
Published: August 2022

Aim. Study of the possibilities of using quantitative parameters of single-photon emission computed tomography (SPECT) with [99mTс]-MIBI as predictors of the effectiveness of neoadjuvant chemotherapy (NAC) in patients with breast cancer (BC).
Materials and methods. The study included 47 patients with ВС T1-4N0-3M0 stages. SPECT was performed before and after the 2nd course of NAC, a scintigraphic study was performed 20 minutes and 2 hours after the administration of [99mTс]-MIBI with the calculation of the tumor/background accumulation coefficient (TB) and the retention index (IR).
Results. When comparing quantitative parameters between groups of patients with stabilization, partial regression of the tumor and complete regression, no statistically significant relationships were noted. Subsequently, the patients were divided into groups with no tumor response to therapy and with an objective tumor response (partial and complete tumor regression). IR demonstrated a statistically significant difference in these groups - a lower indicator was observed in patients with an objective response to the treatment. ROC-analysis was used to assess the threshold values ​​in predicting response to therapy, which demonstrates that IR is a predictor of moderate strength and, at a value less than 0.175, predicts an objective response to NAC with a sensitivity of 75% and a specificity of 60%.
Conclusion. The use of SPECT with [99mTc]-MIBI at the stages of preoperative treatment can provide not only a quick assessment of the response, but also be an early indicator of therapy resistance. Retention index values ​​less than 0.175 predict an objective response to NAC with a sensitivity of 75% and a specificity of 60%.
Multifield brachytherapy for multifocal retinoblastoma
Authors: Котова Елена , Яровой Андрей , Голанов Андрей , Ушакова Татьяна , Яровая Вера
Published: August 2022

Multifocal retinoblastoma (RB) is the most severe course variant of this disease, the incidence among patients with binocular RB is 67-70%. Despite the high rates occurrence of this form in clinical practice, there is no information in the literature about the efficacy of its treatment using brachytherapy (BT) and various modifications (multifield BT, simultaneous using of two plaques). The safety of repeated irradiation is unexplored.
The aim of the study is to evaluate the efficacy of multifield BT in the treatment of multifocal RB.
Materials and methods: in the period from 2007 to 2021 BT was used as a local treatment for RB in 136 patients (146 eyes), among them 42 patients (46 eyes – 106 tumors) with multifocal RB were treated by multifield BT. The mean age at the time of treatment was 26.8 months (range, 6-67 months). Irradiation was performed in the following variants: from two fields – 36 eyes, from three fields – 8 eyes, from four fields – 1 eye, from five fields – 1 eye. BT with simultaneous using of two plaques in different parts of the fundus was performed in 6 patients (6 eyes), BT with sequential displacement plaque to the neighbouring or the opposite zone - in 15 patients (15 eyes).
Results: complete tumor regression was achieved in 70% (n=74), partial tumor regression - in 22% (n=23). Progressive disease was observed in 7% (n=8), tumor recurrence in 4 months after BT - in 1% (n=1). Local control of the tumor was achieved in 92% of cases. The only eyes were preserved in 90% of cases. BT-related complications were observed in 48% of cases (22 eyes) with mean follow-up 55 months (range, 3-157 months). A comparative analysis efficacy of multifield BT and single-field BT was performed additionally, as a result was shown that multifield BT allows to achieve a comparable tumor local control (94%; p= 0.128) with a clearly greater number of BT-related complications (46%; p=0.02), which does not significantly affect the eye-retention rate of the treatment (83%; p=0.16).
Conclusion: multifield BT has shown high efficacy and relative safety in the treatment of patients with multifocal RB.
Uma Nova Ética Universalista Para A Economia de Mercado sob a perspectiva do Capitalismo Humanista
Authors: Sayeg Ricardo Hasson , Hudler Daniel Jacomelli
Published: August 2022

Economia de mercado funda-se no capitalismo liberal. Diante dos desafios da pós- modernidade (legitimidade, representatividade, concentração de renda), aventa-se a possibilidade de construção dogmático-jurídica e epistemológica de um capitalismo humanizado, com esteio na fraternidade, integrado pela ética, a partir da estrutura normativa dos Direitos Humanos. Hipóteses: i) capitalismo não se esgota enquanto resposta para distribuição de bens e serviços; ii) ordenamento jurídico brasileiro incorpora ética universalista humanista. Emprega-se o método hipotético-dedutivo, auxiliado da pesquisa bibliográfica. Conclui-se: 1 – capitalismo não se esgotou na compreensão (neo)liberal (século XX), pois conjunto de valores pode ser reformulado; 2 – ordenamento jurídico brasileiro adota ética universalista humanista.
RESEARCH OF CONSUMER PREFERENCES OF RUSSIANS IN THE SERVICE SPHERE
Authors: Гайсина Сабина Альбертовна , Сахбиева Амина Ильдаровна
Published: August 2022

Целью данного исследования является выявление основных тенденций формирования потребностей россиян в сфере услуг. Статья будет направлена на изучение факторов, которые непосредственно оказывают влияние на данный процесс. В ходе исследования будут проведено социальное анкетирование, с помощью которого можно определить ключевые потребностей в сфере услуг и их взаимосвязь с политической, экономической и социальной обстановкой в России.

The purpose of this study is to identify the main trends in the formation of the needs of Russians in the service sector. The article will be aimed at studying the factors that directly affect this process. During the study, a social survey will be conducted, with the help of which it is possible to determine the key needs in the service sector and their relationship with the political, economic and social situation in Russia.
REVIEW OF THE USE OF MACHINE LEARNING METHODS IN DRUG DEVELOPMENT
Authors: Москалев Владимир Борисович , Сидоренко Денис Александрович
Published: August 2022

В данной статье рассмотрены современные применения методов машинного обучения, которые успешно применяются на каждом этапе разработки лекарств. Алгоритмы машинного обучение позволили улучшить все процессы, требующие принятия решений, такие как анализ свойств малых органических структур, нахождение целевых белков, нахождение новых молекул с целевыми свойствами. Понимание и проверка разработанных методов машинного обучения важны для снижения рисков при разработки лекарств.

This article discusses modern applications of machine learning methods that are successfully applied at every stage of drug development. Machine learning algorithms have made it possible to improve all processes that require decision-making, such as analyzing the properties of small organic structures, finding target proteins, and finding new molecules with target properties. Understanding and validating the developed machine learning methods is important to reduce risks in drug development.
MODELING OF THE ASSESSMENT OF THE PREDISPOSITION TO BANKRUPTCY OF ENTERPRISES
Authors: Дзыгман Александр Сергеевич , Малаев Иван Алексеевич , Кругляк Людмила Ивановна , Спиридонов Андрей Викторович
Published: August 2022

В статье систематизированы основные модели, позволяющие прогнозировать вероятность банкротства (финансово-экономической несостоятельности) предприятий, их основные преимущества и недостатки.

The article systematizes the main models that allow predicting the probability of bankruptcy (financial and economic insolvency) of enterprises, their main advantages and disadvantages.
CONCEPTS AND THEORIES OF SOCIAL ADVERTISING: SOCIOLOGICAL ANALYSIS
Authors: Босов Дмитрий Вячеславович , Сапожникова Евгения Игоревна
Published: August 2022

В статье получил отражение анализ феномена социальной рекламу через призму социологических теорий и подходов, таких как структурно-функциональный (Т.Парсонс, Р.Мертон, Д.Тернер), коммуникативный (О.А.Феофанов, Г.Г.Почепцов), информационно-политический (И.В.Голота, С.А.Жаров), системный анализ (Н.Луман), социологическая теория коммуникации (Л.Н. Федотова), теория жизненных сил в рамках виталистской социологической парадигмы (С.И.Григорьев, Л.Г.Гуслякова, В.Н.Иванов, В.И.Патрушев, Ю. Е.Растов). Выявив соотношение теорий социальной рекламы, авторы пришли к выводу о важности комплексного, полидисциплинарного изучения феномена социальной рекламы.

The article reflects the analysis of the phenomenon of social advertising through the prism of sociological theories and approaches, such as structural-functional (T.Parsons, R.Merton, D.Turner), communicative (O.A.Feofanov, G.G. Pocheptsov), information-political (I.V.Golota, S.A. Zharov), system analysis (N.Luhmann), sociological theory of communication (L.N.Fedotova), theory of vital forces within the framework of the vitalist sociological paradigm (S.I.Grigoriev, L.G.Guslyakova, V.N.Ivanov, V.I.Patrushev, Yu.E.Rastov). Having revealed the relationship between theories of social advertising, the author came to the conclusion about the importance of a comprehensive, multidisciplinary study of the phenomenon of social advertising.
IMPROVING TAX CONTROL IN THE CONTEXT OF DIGITALIZATION OF MACROECONOMIC PROCESSES
Authors: Никитенко Екатерина Юрьевна , Недорезова Елена Сергеевна
Published: August 2022

В условиях цифровизации экономики ведущих стран мира появляется необходимость в модернизации налогового контроля для пресечения уклонения от уплаты налогов. В данной статье рассмотрены актуальные проблемы, сдерживающие модернизацию налогового контроля и найдены пути их решения. Сделан вывод о необходимости усовершенствования налоговых органов и развития цифровой экономики.

In the conditions of digitalization of the economy of the leading countries of the world, there is a need to modernize tax control to prevent tax evasion. This article discusses the current problems hindering the modernization of tax control and found ways to solve them. The conclusion is made about the need to improve tax authorities and the development of the digital economy.
THE GENESIS OF IDEAS ABOUT THE VERIFICATION OF TESTIMONY ON THE SPOT IN DOMESTIC CRIMINAL PROCEEDINGS
Authors: Каюкова Алена Алексеевна , Усенко Никита Викторович , Милова Ирина Евгеньевна
Published: August 2022

В статье анализируется история появления в системе следственных действий проверки показаний на месте. Достаточно давно известный познавательный прием, тем не менее, длительное время не получал нормативной регламентации, поскольку не признавалась его самостоятельность. Авторами показываются его познавательные возможности для целей доказывания.

The article analyzes the history of the appearance of on-site verification of testimony in the system of investigative actions. A well-known cognitive technique for a long time, however, did not receive regulatory regulation for a long time, since its independence was not recognized. The authors show its cognitive capabilities for the purposes of proof.
ANALYSIS OF KAZAKHSTAN'S PARTICIPATION IN THE INTERNATIONAL TRADE IN TECHNOLOGY
Authors: Авдеева Ольга Александровна
Published: August 2022

Рассмотрены тенденции участия Казахстана в международной торговле технологиями. Доказано, что между экспортом и импортом высокотехнологичной продукции Казахстана наблюдается сильная корреляционная связь. Импорт высокотехнологичной продукции является важным каналом международного трансфера технологий для Республики Казахстан.

The tendencies of Kazakhstan's participation in the international trade in technologies are considered. It is proved that there is a strong correlation between exports and imports of high-tech products of Kazakhstan. Import of high-tech products is an important channel for international technology transfer for the Republic of Kazakhstan.
ON THE QUESTION OF ATTRIBUTIVE CHARACTERISTICS OF INVESTIGATIVE SITUATIONS AND THEIR RELATIONSHIP WITH THE PLANNING OF INVESTIGATION IN CRIMINAL CASES ON CRIMES IN THE SPHERE OF ECONOMY
Authors: Никоноров Максим Витальевич
Published: August 2022

В статьи приводится анализ положений отечественной нормативно-правовой базы и юридической доктрины по вопросам атрибутных и содержательных характеристик понятия «следственная ситуация». Вместе с этим исследуются вопросы относительно связи вышеназванного явления с процедурой планирования расследования по уголовным делам о преступлениях в сфере экономики.

The article provides an analysis of the provisions of the domestic legal framework and legal doctrine on the attributes and content characteristics of the concept of "investigative situation". At the same time, questions are being investigated regarding the connection of the above phenomenon with the procedure for planning an investigation in criminal cases on crimes in the sphere of the economy.
LEGAL BASES AND FEATURES OF THE FUNCTIONING OF THE JAPANESE POLICE SYSTEM
Authors: Кобец Петр Николаевич , Тарасевич Ольга Викторовна
Published: August 2022

Авторским коллективом проведен анализ правовых основ и особенностей функционирования японской полицейской системы. Авторы приходят к выводу, что японское правительство создало систему полиции европейского образца еще в 1874 г. под централизованным контролем полицейского бюро в МВД. И сегодня Национальное полицейское агентство определяет общие стандарты и политику, при этом являясь центральным координирующим органом для всей полицейской системы страны.

The team of authors analyzed the legal foundations and features of the functioning of the Japanese police system. The authors come to the conclusion that the Japanese government created a European-style police system as early as 1874, under the centralized control of the police bureau in the Ministry of Internal Affairs. And today, the National Police Agency determines the general standards and policies, being the central coordinating body for the entire police system of the country.
FEATURES OF MONGOLIAN SPEECH ETIQUETTE
Authors: Зорина Виктория Владимировна , Мунхсулд Мунхболд
Published: August 2022

Статья посвящена особенностям монгольского речевого этикета. Приведены примеры речевых формул, используемых при приветствии, прощании и обращении к старшим.

The article discusses the features of the Mongolian speech etiquette. Examples of speech formulas used when greeting, saying goodbye and addressing elders are given.
DETERMINATION OF THE LEVEL OF MORAL EDUCATION OF FOREIGN STUDENTS
Authors: Приходько Ольга Владимировна , Худоиев Диловар Азимович
Published: August 2022

В статье рассматривается проблема нравственного воспитания иностранных слушателей СибЮИ МВД России. Отмечена важная роль нравственного и патриотического воспитания в процессе профессиональной подготовки в образовательных организациях МВД России, представлены результаты методики на определение уровня нравственной воспитанности иностранных слушателей «Пословицы».

The article deals with the problem of moral education of foreign students of the SibUI of the Ministry of Internal Affairs of Russia. The important role of moral and patriotic education in the process of professional training in educational organizations of the Ministry of Internal Affairs of Russia is noted, the results of the methodology for determining the level of moral education of foreign listeners of "Proverbs" are presented.
PHRASEOLOGICAL UNITS OF THE SEMANTIC GROUP «APPEARANCE» IN THE ENGLISH LANGUAGE
Authors: Семендяева Юлия Юрьевна
Published: August 2022

В данной статье рассматривается понятие фразеологической единицы. Анализируются семантические особенности англоязычных фразеологизмов. Кроме того, рассматриваются группы и подгруппы выражений с положительной, отрицательной и нейтральной оценкой и их примеры.

This article discusses the concept of a phraseological unit. The semantic features of English phraseological units are analyzed. In addition, groups and subgroups of expressions with positive, negative and neutral evaluation and their examples are considered.
THEREMIN. MUSIC FROM THE AIR
Authors: Музалевская Варвара Александровна , Микаева Светлана Анатольевна
Published: August 2022

Авторами описаны история развития электромузыкального инструмента терменвокс и принцип его работы. Терменвокс использует принцип гетеродина для генерации звукового сигнала.

The authors describe the history of the electric musical instrument theremin and the principle of its operation. The theremin uses the principle of a heterodyne to generate an audio signal.
DEVELOPMENT OF ISOTONIC TEA DRINK
Authors: Клемешов Дмитрий Анатольевич , Бывшева Анна Сергеевна
Published: August 2022

В публикации рассмотрена возможность улучшения органолептических и функциональных свойств спортивного изотонического напитка за счёт добавления в состав напитка дополнительных ингредиентов - чая ройбос и облепихи. Была разработана рецептура чайного изотонического напитка. Использование облепихи и чая ройбос как вспомогательных компонентов было обосновано с точки зрения химического состава и физиологических свойств обоих ингредиентов.

In the publication the possibility of improving the organoleptic and functional properties of sports isotonic drink by adding rooibos tea and sea buckthorn, as additional ingredients. There was developed a recipe for an isotonic tea drink with regard to obtaining the final physico-chemical and organoleptic indicators. The use of just sea buckthorn and rooibos tea as auxiliary components was justified in terms of the chemical composition and physiological properties of both ingredients.
INTEGRATED CIRCUITS
Authors: Богданов Даниил Сергеевич , Микаева Светлана Анатольевна
Published: August 2022

Авторами описаны интегральные микросхемы. Представлены микросхемы НИИ «Пульсар». Современный вид микросхемы, описаны виды, устройства микросхем и корпусов микросхем.

The authors describe integrated circuits. Microcircuits of the Pulsar Research Institute are presented. The modern type of microcircuit, the types, devices of microcircuits and microcircuit housings are described.
INFORMATION IN BLACK HOLE
Authors: Хурамшин Рустем Иштимерович , Хурамшин Иштимер Шагалиевич
Published: August 2022

В статье обсуждается острый вопрос среди астрофизиков, что происходит с информацией при поглощении ее в черную дыру? Авторы предлагают свой концептуальный ответ на данный вопрос, который заключается, что информация полностью трансформируется обратно в гравитацию. Итак, гравитация обладает не только силой притяжения, но в то же время является хранилищем информации.

The article discusses an acute question among astrophysicists, what happens to information when it is absorbed into a black hole? The authors offer their own conceptual answer to this question, which is that information is completely transformed back into gravity. So, gravity has not only the force of attraction, but at the same time is a repository of information.
HARD DRIVES
Authors: Клевцов Николай Андреевич , Микаева Светлана Анатольевна
Published: August 2022

Авторами описаны жесткие диски, принципы их работы и применение в различных областях электроники. Представлены примеры перспективных разработок.

The authors describe hard drives, the principles of their operation and application in various fields of electronics. Examples of promising developments are presented.
TRIBOELECTRIC EFFECT AND ITS APPLICATION IN DIFFERENT FIELDS OF ELECTRONICS
Authors: Базаржапова Аурика Баировна , Микаева Светлана Анатольевна
Published: August 2022

Авторами описан трибоэлектрический эффект, принцип работы и его применение в различных областях электроники. Представлены примеры перспективных разработок с использованием трибоэлектрического эффекта.

The authors describe the triboeletric effect, principle of operation and its application in different fields of electronics. Examples of promising developments using triboelectric effect are presented.
APPLICATION OF AN IONISTOR IN A STABILIZED COMBINED POWER SUPPLY
Authors: Русаченок Никита Александрович , Петренко Юрий Петрович , Микаева Светлана Анатольевна , Журавлева Юлия Алексеевна
Published: August 2022

Авторами описана структура комбинированного источника электропитания с применением ионистора, используемая в бортовых космических системах. Представлена блок-схема опытного образца.

The authors describe the structure of a combined power supply source with the use of an ionistor used in onboard space systems. A block diagram of the prototype is presented.
MOTION SENSORS
Authors: Коротков Владислав Валерьевич , Микаева Светлана Анатольевна
Published: August 2022

Авторами представлены датчики перемещения, дано определение и принцип работы. Описана классификация и их основные характеристики.

The authors present motion sensors, the definition and principle of operation are given. The classification and their main characteristics are described.
DEVELOPMENT OF DATABASES FOR THE MUSEUM EXPOSITION OF THE NATIONAL RESEARCH UNIVERSITY «BSU»
Authors: Мбоутчоуанг Хокетча Чакил Орсел , Ядута Анна Зауровна
Published: August 2022

В статье рассмотрена разработка баз данных для музейной экспозиции НИУ “Белгу”, что является одной из наиболее часто встречающихся проблем нашего времени - цифровизация профессий. Это требует использования баз данных и различных языков программирования.

The article discusses the development of databases, for the museum exposition of the National Research University “BSU" it’s one of the most common problems of our time, the digitalization of professions. This requires the use of databases and various programming languages.
Analisis Data Mining Menggunakan Algoritma Fuzzy C-Means Pada Data Transaksi Penggunaan Armada di Perusahaan Travel
Authors: Astuti Rini , Nugroho Achmad , Wijaya Yudhistira Arie , Purwanti Santi
Published: August 2022

Hasil pengamatan pada perusahaan yang  bergerak di bidang travel kendaraan khususnya mobil, berkembangnya usaha ini dengan banyaknya jumlah pelanggan yang mencakup wilayah Cirebon, Indramayu, Majalengka dan Kuningan (atau dikenal dengan CIAYUMAJAKUNING) khususnya, maka menuntut kecepatan dan keakuratan dalam mempersiapkan armada kendaraan atau mobil travel yang akan digunakan.
Penelitian yang akan digunakan pada penelitian ini adalah pendekatan kuantitatif. Penelitian ini bertujuan untuk mengetahui penggunaan armada travel dalam CV Dalan Dolan. Dalam penelitian ini digunakan metode Clustering Fuzzy C-Means. Berdasarkan tujuan serta armada yang digunakan pada travel CV Dalan Dolan. Karakteristik dari tiap cluster-nya adalah, cluster 0 berdasarkan armada yang digunakan yaitu armada Mercedes Big Bus yang masuk ke dalam armada kapasitas besar, cluster 1 berdasarkan armada yang digunakan yaitu Toyota Avanza, Daihatsu Xenia, Daihatsu Sigra yang masuk ke dalam armada kapasitas kecil.
Dari hasil penelitian menggunakan model Algoritma Fuzzy C-Means didapatkan 2 kelompok cluster yang optimal berdasarkan cluster distance performance yaitu cluster 0 dan cluster 1 yang jumlah masing-masing kelompoknya adalah cluster 0 berjumlah 33 items, cluster 1 berjumlah 166 items. Kemudian dilakukan pengujian processing data dari k=2 sampai k=20 dan dibandingkan dengan nilai dbi yang dihasilkan dari tiap cluster, nilai k terbaik / ideal adalah 2 dengan nilai dbi sebesar 0.074 dan nilai dunn index sebesar 0.7881975.
Effect of tumor necrosis factor inhibitors on the risk of adverse cardiovascular events in patients with psoriasis
Authors:   beijing hospital, Li Peng , Liu Junjun
Published: August 2022

Review question / Objective: Previous studies have indicated a cardioprotective effect of tumor necrosis factor inhibitor (TNFi) therapy in adult patients with psoriasis (Pso). However, most were retrospective studies, and the association between cardiometabolic comorbidities and major adverse cardiovascular events (MACE) has not been validated in randomized controlled trials (RCTs). Condition being studied: Because the available evidence has recently increased, we performed the present updated meta-analysis and meta-regression of cohort studies and RCTs to evaluate whether TNFi therapy can decrease the risk of MACE among patients with Pso and to assess the associations between cardiometabolic comorbidities and MACE.
Power Quality Problems Due to Transformer Inrush Current
Authors: Amir Tokić  , Ivo Uglešić
Published: August 2022

Transformer energization can produce a large nonsinuoidal inrush current which contains both odd and higher order harmonic components that can put transformer winding under mechanical stress. Additionally, they can cause irregular tripping of harmonic protection relays. Furthermore, in relatively weak power systems, such as is the Bosnian system, the superposition of harmonic components with system resonance frequencies may produce temporary overvoltages (TOV). Transformer winding failures and metal oxide surge arrester (MOA) energy stresses can occur due to TOV. The paper demonstrates a case study of an energization of a 220/110 kV transformer and power quality problems that can appear due to higher harmonics. Energy stresses of MOA provoked by transformer energization are considered in the paper.
Measurement and Simulation of Hydro-Generator’s Asynchronous Operation
Authors: Zlatko Maljković  , Ž. Zebić  , M. Pavlica
Published: August 2022

The extended testing of hydro-generator with Pelton turbine (rated 35 MVA) was performed on a generator whose lifespan expired and it was going to be replaced. This was the perfect opportunity to do some specific and uncommon testing. The complex testing plan was designed in order to enable recording of as much relevant data as possible (electrical, electromechanical, mechanical). Therefore, in some phases of testing, 29 to 44 quantities were measured simultaneously. Among the tests, there are short circuits with lowered voltage, bad synchronization at approximate angle of 15 degrees, asynchronous operation, generator overspeed and operation with short circuited field winding on one pole. The most interesting and the most critical operation during this testing is asynchronous operation of hydro-generator [1, 2, 3, 4, 5], which is also very dangerous for generator and drive equipment. During such operation synchronous generator operates at a speed unequal to rated speed. This slip causes increased damping winding currents, which increases the thermal stress of this winding beyond the designed level. This makes these tests very infrequent. Asynchronous operating was achieved by decreasing the excitation current. Complex mathematical model for computer simulation of hydro-generator’s asynchronous operation has been made, taking into consideration the magnetic saturation, damper winding and generator transformer’s influence. Results obtained by simulations have been compared to those obtained by measurements.
Evaluation of Different Methods for Voltage Sag Source Detection
Authors: Boštjan Polajžer  , Gorazd Štumberger  , Sebastijan Seme
Published: August 2022

This paper compares and evaluates three different methods for voltage sag source detection. First method (method I) is based on the assumption, that the energy flow at the monitoring point increases during downstream events and decreases during upstream events. Second and third method (methods II and III) are both based on the assumption that currents measured at the monitoring point increase during downstream events and decrease during upstream events. The slope of a current-voltage trajectory is investigated in method II, while a real current component is observed within method III. Both current-based methods (II and III) require fundamental harmonic components of sampled voltages and currents, which are extracted using discrete orthogonal series expansion, such as Fourier or Walsh. Algorithms of this type are especially appropriate for studying steady-state and periodically repeating conditions. Voltage sags are, on the contrary, transient disturbance events. Thus, usage of the discussed algorithms may not be appropriate. Furthermore, criteria within methods II and III are checked for each phase individually. In the cases of asymmetrical voltage sags exact interpretation of the obtained results, therefore, might not be possible. Method I is, on the contrary, based on instantaneous values of line voltages and currents, while three-phase criterion is used. An exact interpretation of the results obtained by this method is, therefore, also possible in cases of asymmetrical voltage sags. All the discussed methods for voltage sag source detection have been tested by applying extensive simulations and field tests. The results for ground faults, asymmetrical voltage sags, upstream events and motor starting have been analyzed in order to evaluate all the discussed methods. The obtained results show that all discussed methods are very successful in cases of heavy motor starting and other symmetrical voltage sags. In cases of asymmetrical voltage sags the methods II and III do not work well, especially for those originating from the upstream side, while the method I is not successful only in particular cases of voltage sags due to upstream ground faults. Based on the performed evaluation it can be concluded, that further development is still needed to increase the degree of confidence in the discussed methods.
The impact of events in the Slovene high – voltage network on the power quality in the distribution networks
Authors: Klemen Deželak  , Andrej Korak  , Tatjana Konjic  , Gorazd Štumberger  , Jože Voršič
Published: August 2022

This work analyses the impact of different events in Slovene high-voltage network on power quality in the 20 kV and 0.4 kV distribution networks. In order to perform the analysis a simplified dynamic model of the Slovene power system was build in the program package Matlab/Simulink, using toolbox PowerSys. The obtained model is appropriate for simulation of electromagnetic transients in duration up to a few seconds. It contains simplified dynamic models of all main generators and power transformers installed in the Slovene power system, detailed models of 400 kV, 220 kV and 110 kV networks, simplified models of the neighboring power systems and models of important consumers. The 20 kV and 0.4 kV distribution networks are modeled in the details only in the area of interests. Everywhere else, they are represented as constant loads connected to the 110 kV network. The aforementioned dynamic model was applied to analyze the impact of different events in the Slovene power system on power quality in the 0.4 kV distribution network during transients and in steady states. The power quality in distribution network was analyzed on 0.4 kV busbars in five substations (Cerkno, Škofja Loka, Vevče, Šentjur, Rače) for the following set of events: a switch-off of a 300 MVA (400 kV/110 kV) power transformer in the substation Okroglo; a three-phase short circuit on 110 kV busbars in the substation Kleče; a three-phase short circuit on 20 kV busbars in the substation Rogaška Slatina and a switch-on in a pumping regime of pump-turbine plants Avče and Kozjak which are currently at the design stage. The results obtained show that aforementioned events in some points of Slovene distribution network can cause power quality distortion over that allowed by the power quality standards.
Mitigation of common mode failures at multi-circuit line configurations by application of line arresters against back-flashovers
Authors: M. Kizilcay  , C. Neumann
Published: August 2022

Due to the limited number of corridors multi circuit line configurations are often applied. These overhead lines frequently consist of high towers that are subject to lightning strokes. In case of higher current amplitudes and higher footing resistances due to bad earthing conditions back-flashovers are caused leading to common mode failures and to severe outages. The paper describes investigations performed by means of computer simulations to identify the towers of a multi-circuit line consisting of voltage levels 380 kV, 220 kV and 110 kV that are endangered by back-flashovers of the 110-kV double-circuit lines. The footing resistance of towers of the targeted line section has been measured by an instrument at high-frequency. Influence of various factors on the back-flashover over 110 kV insulator strings has been studied by means of EMTP-ATP simulations. Different current waveforms of the lightning stroke have been used to represent the first stroke and subsequent strokes. The towers are represented by the models described in [3], [8]. Available flashover analysis methods [7], [8], [12], [13] like leader development method by Pigini et al and by Motoyama, and voltage-time integration method by Kind have been applied. The towers at which back-flashover is more likely to occur than at other towers are identified by the time integral of voltage according to Kind. Various factors like tower footing impedance, tower surge impedance and tower height are considered. Application of line a surge arrester is shown to be a successful mitigation technique to reduce the back-flashover rate of those 110 kV lines. The lightning overvoltage performance of surge arresters has been analyzed by means of digital simulations. Based on the results of investigations line arresters were installed on the towers in question. Since the installation no further common mode failure has been observed.
Solving EMC problems in the design of new HV test laboratory
Authors: Ivo Uglešić  , Miroslav Křepela  , Viktor Milardić
Published: August 2022

The paper deals with solving electromagnetic compatibility (EMC) problems in the design of a new, case study, industrial high voltage test laboratory, intended to be used for testing of transformers and other apparatus up to 550 kV rated voltage. Modern high voltage test facilities are equipped, apart from primary test devices like AC, DC and impulse voltage generators etc., also with sophisticated numerical measuring instruments and informatics technology. Since such devices are sensitive to transient overvoltages, the highest degree of EMC is to be secured. This can be achieved by proper earthing and screening of test laboratory, what shall be designed in a way to satisfy all requirements conditioned by building lightning protection, personal protection and system earthing, avoiding electromagnetic compatibility disturbances at the same time. One of the main tasks is solving electromagnetic compatibility problems caused by outdoor electromagnetic disturbances originating from various unknown sources. Those disturbances and interferences may seriously influence measuring accuracy and readings of test devices, what consequently leads to false results. The stated is especially relating to partial discharge measurements. As to avoid such disturbances, the laboratory shall be completely screened with a net forming optimally designed Faraday cage. On the other hand, at high voltage tests with impulse voltages, especially with chopped tail waves, steep transient overvoltages may be generated. As a consequence, high transient potential differences between particular points along the earth electrode may occur, what can even lead to flashovers between parts of it. Therefore is of utmost importance to provide proper earthing and low inductance current return path for impulse high voltage test equipment where high frequency transients are to be anticipated. Improper earthing and bonding may result, apart from mentioned flashovers, in severe induced voltages in secondary cables with consequential influence on test results, possible destruction of measuring instruments and hazardous touch voltages for personnel. For analyzing transient potential differences, it is important to model, with maximum accuracy, impulse test circuit (impulse generator, chopping spark gap, voltage divider, Faraday cage, fundament earth electrode, earthing strips, earthing rods etc.). Magnitude of transient potential difference between particular points is proportional to earth electrode inductance, i.e. low inductance of earth electrode will result in decrease of transient potential difference.
Improvement of the transmission and sub-transmission overhead lines lightning performance using line arresters – Experience in Brazil
Authors: Jorge Luiz De Franco  , José Pissolato Filho
Published: August 2022

Lightning has been reported as the major cause of non-scheduled outages that occur in Brazilian’s  power system, being responsible for approximately 50 – 70% of the outages verified in overhead lines  with rated voltages up to 230 kV and creating many issues for power supply utilities and consumers.  In agreement with the information of the National Institute for Space Researche (INPE) Brazil is the  country with the largest incidence of lightning activities in the world, with about 50 - 70 million  lightning outages a year somewhere in the country. With this considerable amount of lightning caused  distubances, the resulting damages caused to the electric power systems are high such that the costs of  losses and repairs exceed an annual value of 350 million dollars. This fact has been taken up by  several power supply utilities and industrial consumers and caused them to invest in partnership with  universities and research centers in the development of theoretical studies and the promotion of  improvements along the critical sections of their overhead lines with poor lightning performance,  thereby increasing their reliability. In many cases line arresters have been considered as the most  effective method to improve the lightning performance.  In Brazil, the first application of line arresters was in the middle of the nineties and from this time on  more than 3,000 units of gapless line arresters were installed on overhead lines from 34.5 kV up to  230 kV. The analysis and evaluation of overhead lines lightning performance before and after the line  arresters installation have shown a good effectiveness, with average indexes for the improvement  higher than 70%. Good field experience and the proven results obtained in the   the  overhead lines lightning performance after the line arresters installation have been encouraging more  and more Brazilian power supply utilities and industrial consumers to develop studies to evaluate the  line arresters application along their overhead lines presenting poorer lightning performance.  This paper presents information about the experience of the Brazilian power supply utilities as well as  industrial consumers in the application of line arresters to improve the overhead lines lightning  performance. Procedures used to optimize the characteristics of the line arresters, quantity and location  along the critical sections of the lines; field experience as well as the lightning performance of the  lines before and after the line arresters application are presented and discussed.
PERFORMANCE OF PARALLEL SURGE ARRESTERS
Authors: A. Haddad  , H. Griffiths  , M. Osborne
Published: August 2022

The operation of parallel surge arresters can improve energy absorption capability if the arresters are   similar and are installed close to each other. However, it has been reported that any small difference in   the individual V-I characteristics can lead to unbalance in current sharing. When the arresters are   installed some distance away from each other, travelling wave effects can modify the effectiveness of   parallel arresters for surge overvoltage protection and, in this case, detailed simulations are required to   ascertain the level of protection. Such a situation occurs in practice with large substations or short   underground cable connections. Various studies have shown that a requirement for two-arrester   protection is closely dependent upon the type and length of cable used.   In the case of overhead lines, the distances are much bigger and the main objective of line arresters is   to reduce the flashover rates due to surge overvoltages. This is especially relevant to lines located in   regions of high lightning activity, lines with compact/uprated design where the phase-to-phase and   phase-to-earth air clearances are reduced.   In this paper, we present a study of parallel arresters considering the separation distance and their   application to overhead lines. Various scenarios of overhead line configurations were considered and   the overvoltage levels were calculated for each case. Assessment of flashover performance is also   conducted for a number of conditions. A number of calculation techniques were used and compared.
La adecuada gestión de archivos como mecanismo para transparentar los actos de la Administración Pública en el Perú
Authors: Cárdenas Arce Heidi Soraya
Published: August 2022

La adecuada gestión de los archivos en las entidades de la administración pública es clave para garantizar la transparencia de los actos de gobierno y por ende para la protección del derecho de acceso a la información pública reconocido en el Perú como un derecho fundamental que se encuentra regulado en el inciso 5º del artículo 2º de la Constitución Política del Perú.Al respecto, existe un significativo número de casos en los que no se entrega la información solicitada por el ciudadano, argumentando que en virtud del artículo 13º del Texto Único Ordenado de la Ley Nº 27806 no existe obligación de las entidades de crear o producir información con la que no se cuenta al momento de efectuarse el pedido. Sin embargo, existe la obligación de las entidades de cumplir los procedimientos técnicos archivísticos a fin de contar con archivos debidamente organizados que permitan la rápida ubicación de la información solicitada, evitando que la misma sea deteriorada o destruida sin el correspondiente procedimiento establecido para tal efecto. Lo contrario constituye una grave afectación a este derecho fundamental.
The Implementation Evaluation of Drug Demand Plan in Pharmacy Installations of Dr Fauziah Hospital Bireuen Aceh Province
Authors: Sari Intan , Asriwati Asriwati , Diana Vivi Eulis
Published: August 2022

Pharmaceutical services are direct and responsible services to patients related to pharmaceutical preparations with the aim of achieving definite results to improve the quality of life of patients. The unavailability of drugs at the Pharmacy Installation is usually caused by delays in the arrival of drugs after they are ordered because its stock is empty at the distributor. The purpose of this study was to analyze the planned need for drugs that were lacking in the Pharmacy Installation at Dr. Fauziah Hospital Bireuen Regency, Aceh Province in 2021. The research used qualitative design. Characteristics of key informants were Head of Pharmacy Installation, Person in Charge of Pharmaceutical Supplies, Responsible for Pharmacy Warehouse, Responsible for Outpatient Distribution, Responsible for Inpatient Distribution, Pharmacy Installation Administration Officer, Pharmacy Officer, Distributor Officer, while the main informants were employees. Data collection technique was done by using the Triangulation method. Data analysis used descriptive qualitative with data triangulation stages of technique, source and time.The results of the study showed that planning was done by a planning team that had been formed. The drug procurement process more often used the ordering consumption method based on the e-catalog. In the distribution process, it was done by direct distribution.It is expected that it is necessary to improve the Pharmacy Installation of Dr. Fauziah Hospital Bireuen Regency. The Installation party should further improve the Management Information System (SIM) in queuing drug data.
Evaluation of Multiple Pregnancies Who Delivered During The Last Four Years In Our Tertiary Hospital
Authors: ŞEHİRLİ KINCI Özge , KINCI Mehmet Ferdi , TAŞTAN Leyla , SARUHAN Ercan , SİVASLIOĞLU Ahmet Akın
Published: August 2022

Aim: We aimed to evaluate the outcomes of multiple pregnancies between January 2016 and December 2020 in our hospital, which is a tertiary center.

Materials and Methods: 107 multiple pregnancies were included in the study among 6567 pregnant women who were delivered between January 2016 and December 2020 in Muğla University Training and Research Hospital Obstetrics and Gynecology Clinic. Of these retrospectively evaluated pregnant women, 106 were twins and 1 was triplet.

Results: It was determined that 87 (80.18%) twin pregnancies were diamniotic-dichorionic, 11 (10.37%) were dichorionic-monoamniotic, and 8 (7.54%) were monochorionic-monoamniotic, respectively. 76 (71.69%) of the deliveries were with preterm delivery and 30 (28.3%) of the pregnant women were delivered at term. Twelve (11.1%) twin pregnancies were delivered by vaginal delivery, and 96 (88.9%) by cesarean section (C/S). No statistical difference was observed in terms of blood loss when the C/S and vaginal delivery groups were compared. When compared in terms of hospitalization time, it was found that the hospitalization period was shorter in the vaginal delivery group.

Conclusion: The clinical results of our study are similar to the current literature. In our study, what we evaluated differently from the literature is blood loss and hospitalization time between C/S and vaginal delivery. There was no difference between C/S and vaginal delivery in terms of blood loss, and it was observed that the hospitalization period of patients who had vaginal delivery was shorter.