bluuebunny/crossref_metadata_2025 huggingface dataset:
A theoretical model of efficient phagocytosis driven by curved membrane proteins and active cytoskeleton forces
Authors: Sadhu Raj Kumar , Barger Sarah R. , Penič Samo , Iglič Aleš , Krendel Mira , Gauthier Nils C. , Gov Nir S.
Published: November 2022

We model the process of phagocytosis of rigid particles by a vesicle containing curved membrane-bound protein complexes, which recruit the protrusive force of actin polymerization, and facilitate engulfment by self-organizing at the phagocytic cup.
Mammalian gastrulation: signalling activity and transcriptional regulation of cell lineage differentiation and germ layer formation
Authors: Salehin Nazmus , Knowles Hilary , Masamsetti V. Pragathi , Tam Patrick P.L.
Published: November 2022

The interplay of signalling input and downstream transcriptional activity is the key molecular attribute driving the differentiation of germ layer tissue and the specification of cell lineages within each germ layer during gastrulation. This review delves into the current understanding of signalling and transcriptional control of lineage development in the germ layers of mouse embryo and non-human primate embryos during gastrulation and highlights the inter-species conservation and divergence of the cellular and molecular mechanisms of germ layer development in the human embryo.
The role of filamentation in activation and DNA sequence specificity of the sequence-specific endonuclease SgrAI
Authors: Lyumkis Dmitry , Horton Nancy C.
Published: November 2022

Filament formation by metabolic, biosynthetic, and other enzymes has recently come into focus as a mechanism to fine-tune enzyme activity in the cell. Filamentation is key to the function of SgrAI, a sequence-specific DNA endonuclease that has served as a model system to provide some of the deepest insights into the biophysical characteristics of filamentation and its functional consequences. Structure-function analyses reveal that, in the filamentous state, SgrAI stabilizes an activated enzyme conformation that leads to accelerated DNA cleavage activity and expanded DNA sequence specificity. The latter is thought to be mediated by sequence-specific DNA structure, protein–DNA interactions, and a disorder-to-order transition in the protein, which collectively affect the relative stabilities of the inactive, non-filamentous conformation and the active, filamentous conformation of SgrAI bound to DNA. Full global kinetic modeling of the DNA cleavage pathway reveals a slow, rate-limiting, second-order association rate constant for filament assembly, and simulations of in vivo activity predict that filamentation is superior to non-filamenting mechanisms in ensuring rapid activation and sequestration of SgrAI's DNA cleavage activity on phage DNA and away from the host chromosome. In vivo studies demonstrate the critical requirement for accelerated DNA cleavage by SgrAI in its biological role to safeguard the bacterial host. Collectively, these data have advanced our understanding of how filamentation can regulate enzyme structure and function, while the experimental strategies used for SgrAI can be applied to other enzymatic systems to identify novel functional roles for filamentation.
The role of sensory kinase proteins in two-component signal transduction
Authors: Alvarez Adrián F. , Georgellis Dimitris
Published: November 2022

Two-component systems (TCSs) are modular signaling circuits that regulate diverse aspects of microbial physiology in response to environmental cues. These molecular circuits comprise a sensor histidine kinase (HK) protein that contains a conserved histidine residue, and an effector response regulator (RR) protein with a conserved aspartate residue. HKs play a major role in bacterial signaling, since they perceive specific stimuli, transmit the message across the cytoplasmic membrane, and catalyze their own phosphorylation, and the trans-phosphorylation and dephosphorylation of their cognate response regulator. The molecular mechanisms by which HKs co-ordinate these functions have been extensively analyzed by genetic, biochemical, and structural approaches. Here, we describe the most common modular architectures found in bacterial HKs, and address the operation mode of the individual functional domains. Finally, we discuss the use of these signaling proteins as drug targets or as sensing devices in whole-cell biosensors with medical and biotechnological applications.
A Cross-Sectional Investigation of the Impact of Stuttering on Swedish Females and Males in Childhood, Adolescence, and Young Adulthood
Authors: Samson Ineke , Schalling Ellika , Herlitz Agneta , Lindström Elisabeth , Sand Anders
Published: November 2022

Purpose:

We aimed to cross-sectionally describe the impact of stuttering on persons who stutter (PWS): children, adolescents, and young adults. Based on previous research on PWS and psychosocial health in the general population, we hypothesized that (a) the adverse impact of stuttering in PWS would be larger among adolescents than children and young adults and that (b) females, especially adolescent females, would report being more adversely impacted by their stuttering than males.

Method:

We pooled samples of Swedish PWS, obtaining 162 individuals (75 females and 87 males), aged 7–30 years. We measured the impact of stuttering using age-relevant versions of the Overall Assessment of the Speaker's Experience of Stuttering (OASES). The relationship between OASES score, age, and sex was described using a polynomial model with an interaction term between age and sex to allow for potential differences between females and males' age-related curves.

Results:

The average trends were that (a) the impact of stuttering was greater for the adolescents than for the children and young adults, and (b) females, especially adolescent females, were on average more impacted by their stuttering than males. Taking self-reported speech fluency into account did not change this pattern.

Conclusions:

In line with findings on psychosocial health, communication attitude, and self-esteem in the general population, the impact of stuttering seems to be particularly adverse among adolescents, especially female adolescents. Thus, clinicians need to be aware of the risk that young girls who stutter may develop a negative attitude to speech and communication, and this should also be communicated to caregivers and teachers.

Supplemental Material:

https://doi.org/10.23641/asha.21554877
Functional Role of Temporal Patterning of Articulation in Speech Production: A Novel Perspective Toward Global Timing–Based Motor Speech Assessment and Rehabilitation
Authors: Rong Panying , Heidrick Lindsey
Published: November 2022

Purpose:

This study aimed to (a) relate temporal patterning of articulation to functional speech outcomes in neurologically healthy and impaired speakers, (b) identify changes in temporal patterning of articulation in neurologically impaired speakers, and (c) evaluate how these changes can be modulated by speaking rate manipulation.

Method:

Thirteen individuals with amyotrophic lateral sclerosis (ALS) and 10 neurologically healthy controls read a sentence 3 times, first at their habitual rate and then at a voluntarily slowed rate. Temporal patterning of articulation was assessed by 24 features characterizing the modulation patterns within (intra) and between (inter) four articulators (tongue tip, tongue body, lower lip, and jaw) at three linguistically relevant, hierarchically nested timescales corresponding to stress, syllable, and onset–rime/phoneme. For Aim 1, the features for the habitual rate condition were factorized and correlated with two functional speech outcomes—speech intelligibility and intelligible speaking rate. For Aims 2 and 3, the features were compared between groups and rate conditions, respectiely.

Results:

For Aim 1, the modulation features combined were moderately to strongly correlated with intelligibility (R2= .51–.53) and intelligible speaking rate (R2= .63–.73). For Aim 2, intra-articulator modulation was impaired in ALS, manifested by moderate-to-large decreases in modulation depth at all timescales and cross-timescale phase synchronization. Interarticulator modulation was relatively unaffected. For Aim 3, voluntary rate reduction improved several intra-articulator modulation features identified as being susceptible to the disease effect in individuals with ALS.

Conclusions:

Disrupted temporal patterning of articulation, presumably reflecting impaired articulatory entrainment to linguistic rhythms, may contribute to functional speech declines in ALS. These impairments tend to be improved through voluntary rate reduction, possibly by reshaping the temporal template of motor plans to better accommodate the disease-related neuromechanical constraints in the articulatory system. These findings shed light on a novel perspective toward global timing–based motor speech assessment and rehabilitation.
Joint mission planning and spectrum resources optimization for multi‐UAV reconnaissance
Authors: Liao Naiwen , He Panfeng , Du Yihang , Zhang Yu , Chen Yong , Liang Tao
Published: November 2022

In this paper, the problem of mission planning and spectrum resource allocation for cooperative reconnaissance of ground targets with multiple unmanned aerial vehicles (UAVs) is studied. A joint mission planning and spectrum resource optimization algorithm for multi‐UAVs is proposed to improve the information transmission rate by reusing the spectrum of existing users. The joint optimization problem is formulated as mixed‐integer non‐linear programming. The block coordinate descent (BCD) method is further applied to achieve the optimal strategies of mission planning, channel allocation, and power control. Specifically, an improved genetic algorithm (GA) combined with the successive convex approximation (SCA) is used to solve the sub‐problem of mission planning. For the channel allocation sub‐problem, an iterative convergence channel allocation algorithm is proposed. Numerical results show that the proposed algorithm can achieve a higher UAV transmission rate and better robustness than existing algorithms.
An investigation of the Effect of Online News Items and News Paper on The Students’ Writing Outcome of EFL Context
Authors: Mustain Mustain , Susanti Sulfarida , Akhmad Sabarudin
Published: November 2022

This paper aims to report the investigation of the effect of online news items on students’ writing outcome of English as foreign language context. This research used quantitative methods with quasiexperimental research designs with non-equivalent groups’ pretest-posttest design. Two groups which 46 students were the experimental and control groups and both groups were given with some different treatments. Those treatments were given in a balanced and intensive manner without intervention from factors beyond the researcher’s control. The tests were then employed as the instrument to gain data with ANCOVA as design of analysis technique and SPSS as media to compute. The findings showed that online news items have strengthened students’ writing abilities and motivated students to write related problems. The results obtained from this study proven that the P-value (0.016) <0.05 (alpha). A criterion is if the Pvalue <alpha (0.05) means that the hypothesis (H0) is rejected and (Ha) is accepted. There are significant differences in student grades. Therefore, it can be concluded that students taught using online news items media were better than students who only use textbook media.
Analysis of Teacher’s Ability in Setting Learning Objectives, Flow of Learning Objectives, And Modules in The Merdeka Curriculum
Authors: Siregar Lamtiar Ferawaty , Sumanik Novike Bela , Christianto Heru
Published: November 2022

The purpose of this research is to determine the ability of subject teachers in developing learning tools in the independent curriculum. The results showed that as many as 40% of teachers were proficient and 60% of teachers were very proficient in carrying out or modifying learning objectives. As many as 40% are in the poor category, namely subject teachers who have not shown understanding in understanding the concept of teaching modules, and have not been able to modify teaching modules properly according to the goals, needs, and characteristics of the school. A total of 20% were in the sufficient category, namely, the subject teachers were quite good at understanding the concept of the teaching module, and were able to modify the teaching module following the objectives, needs, and characteristics of the school but still needed intensive guidance from resource persons. While 0% are in the advanced category, namely subject teachers understand the concept of teaching modules and are able to modify teaching modules properly according to the goals, needs, and characteristics of the school, but in some aspects, they still need resource guidance, for very advanced category 0% are subject teachers really understand the concept of teaching modules and can modify teaching modules properly according to the goals, needs and characteristics of the school independently.
Digital Marketing Literature Model in The Development of Creative Home Industry Culinary in Makassar City
Authors: Rizal S Muh. , Siraj Muhammad Luthfi , Kasmita Maya
Published: November 2022

This study aims to analyze and find a digital marketing literacy model in the development of the culinary creative home industry in the city of Makassar. This research is designed to produce an innovative and effective digital marketing literacy model with a descriptive qualitative approach. The types of data sources are primary data and secondary data using data collection techniques through observation and interviews with data analysis techniques carried out through interactive techniques, namely data collection, data condensation, data presentation, and verification/conclusion. The results showed that the results showed that; Digital literacy by creative culinary industry players in Makassar City is less effective, this is considered by culinary business actors to lack understanding of the functions of various social media and in creating product content whose quality is still low, and less interactive according to market needs. The findings of this study also formulated a digital marketing literacy model into two very important stages for
culinary industry players in implementing effective digital marketing, namely the Persuasion stage by strengthening knowledge about Social Networking, Maintaining Privacy, and Transliteration. The second is the Decision-Making stage to create a Digital Identity, Create Content, and Self Broadcasting.
Digitization of Health Services at Kakaskasen Health Center, North Tomohon District, Tomohon City
Authors: Rauan Valentino , Wawointana Thelma , Sendouw Recky H. E. , Tarore Steven
Published: November 2022

This study aims to describe the digitization of health services at the Kakaskasen Health Center, North Tomohon District, Tomohon City. This study uses a descriptive qualitative approach, the number of informants is 5 people with data collection techniques namely observation, interviews, and documentation, with data analysis techniques through data reduction, data presentation, and conclusion. The results showed that the Digitization of Health Services at the Kakaskasen Health Center had not yet run well because it was
found that according to the research data, the community did not fully understand the online queuing procedure, how to access it, the completion time was often delayed by up to one hour and the online queue only accelerated the taking of queue numbers but for the time of service there are still frequent delays, service products are not as expected with those that have been set, facilities and facilities are not 100% complete and officers are not good or friendly to the community.
Is International Service-Learning Feasible? A Look at the Student’s Perspectives
Authors: Tsuroyya  , Tandyonomanu Danang , Aji Gilang
Published: November 2022

The purpose of this study was to explore the feasibility of international community service projects for students from Communication Science. The study used an online survey to examine students’perceptions. Data were collected voluntarily from 49 students taking part in service-learning project linked to empower people in rural areas, using open-ended questions. The results show various issues such as cultures, arts, diversity, environment, public health, and food security needed to be addressed in the program.With regards to the international service-learning, the students valued positively the program’s nature and raised some concerns including distance, cost, and cultural differences. The implementation of domestic community service may lack of preparation and clear instructions. Standardized procedures and guidelines of international service projects serve as key factors in optimizing the program’s benefit.
Moral Education Values in Tere Liye's novel Amelia as The Implementation of Student Character Building Through Indonesian Language Learning
Authors: Monika Santy , Riwu Lay , Tarigan Dina Mariana Br.
Published: November 2022

This research is a type of qualitative descriptive research. The subject of this research is the novel Amelia by Tere Liye, namely excerpts from the novel containing the values of moral education. The results showed that there were seven values of moral education in the novel Amelia by Tere Liye, including honesty, compassion, not giving up, being patient, helping, caring and loving peace. Through the description of the values of moral education found in the novel Amelia by Tere Liye, this can be used as a reference for character learning through Indonesian language subjects. Because the analysis of the values of moral education is carried out through intrinsic and extrinsic elements. Mainly the values of moral education in the novel which can be found through the analysis of the extrinsic elements of literary works which are Indonesian language learning materials. So that the extrinsic analysis found through the values of moral education in the novel can be used as a learning tool in Indonesian subjects.
The Correlation Between Teacher’s Hegemony and Students’ Critical Thinking Skills
Authors: Torro Supriadi , Tamrin Sopian , Sadriani Andi , Sunra La , Kasim Nuraeni
Published: November 2022

This research aims to determine the correlation between teacher’s hegemony and the increase of students' critical thinking skills. This research was conducted through descriptive qualitative and inferential methods. The research population was all students of senior high schools in Tana Toraja district, totaling 608. The research sample was 114 determined by the Morgan table and Slovin formula. Cluster sampling technique was used to select respondents. Data were collected by using questionnaire and direct documentation. The data were analyzed using the SPSS ++ 25. The result of the research shows that the relationship between teacher power and students' critical thinking skills at school reveals a significance value of 0.000 < 0.05, which means that the two variables have a significant relationship.
Use of Cyberbullying Language on Instagram Social Media
Authors: Tarigan Dina Mariana Br , Riwu Lay , Monika Santy
Published: November 2022

This research is entitled Use of Cyberbullying Language on Instagram social media. This study aims to describe the use of cyberbullying language on social media Instagram. This research uses the descriptive qualitative method. The results of this study indicate that there are 94 comments using cyberbullying language which contains negative names (called named), 12 comments using cyberbullying language which threatens physical safety (Threatened Physical Harm), and Cyberbullying language use that contains degrading opinions (Opinion Slammed) as many as 96 comments.
Student Self Concept (Case Study at SMP N 1 Kawangkoan)
Authors: Wua Telly , Rorimpandey Widdy , Ratu Jan A. , Mantiri Jeane , Sriana Umbase Ruth
Published: November 2022

This study aims to reveal the mindset of students. The disclosure of mindset will be studied through students' background, academic self-concept, and non-academic self-concept. The research method used is a qualitative approach with data sources from students' teachers and parents at SMP N 1 Kawangkoan. The results showed that a positive non-academic self-concept was able to make students able to process their emotions, have many friends and become honest individuals. On the other hand, a negative non-academic self-concept will make it difficult for students to interact with their social environment and process wrong emotions it leading to actions that are not normal. Students who have a positive self-concept can be categorized as a growth mindset and a negative self-concept can be categorized as a fixed mindset. Students with a growth mindset are students who have an unyielding attitude. He will face all the challenges that are in front of him. Meanwhile, students with a fixed mindset are students who easily give up. He will consider a challenge as an obstacle so that the feeling of stopping fighting arises.
Commitment to Prevent Corruption in The Implementation of Budget Functions in Bone District Legislature
Authors: Bakhtiar  , Sulmiah  , Kasmawati Andi , Mustaring  , Heri Ririn Nurfaathirany
Published: November 2022

The study aims to obtain an overview of (1) the commitment to prevent corruption through the implementation of the budget function of the Bone Regency DPRD, and (2) the factors that influence the commitment to prevent corruption in the implementation of the budget function of the Bone Regency DPRD. The research focused on the implementation of the budget function of the Bone Regency DPRD to explore data and information starting from the planning process and budget determination by the Bone Regency DPRD Budget Agency. Referring to the types of qualitative research and available data sources, the data collection techniques used in this study are: Observation of the situation at the research site, in-depth interviewing, and documentation data. The results showed that, Prevention of corruption in the implementation of the budget function of the Bone Regency DPRD has shown a commitment to avoid the occurrence of potential corruption, and there is some factor affecting the commitment to prevent corruption in the implementation of the Bone Regency DPRD budget.
Complete Systematic Land Registration (PTSL) With Community Participation (PTSL-PM)
Authors: Dita Perwitasari , Tamsil  , Indri Fogar S. , Mahendra Wardhana
Published: November 2022

The land is a means of life for humans, ranging from a place to live to becoming a development asset of a country. Therefore, it is very necessary to have arrangements or ownership rights over land so that each party who controls the land understands the rights and obligations of land ownership. Therefore, it is necessary to have land registration to obtain the legality of ownership of the land rights. Land registration is a series of activities carried out by the government continuously, continuously, and regularly. The importance of land registration for the first time for unregistered land owners and the Government (BPN) as well as the current problems related to land registration for the first time for unregistered lancd owners.
Employee’ Innovative Work Behavior
Authors: Soputan Grace Jenny , Sumual Tinneke E. M.
Published: November 2022

The purpose of this study was to analyze the innovative work behavior of employees at Manado State University. Using qualitative research with the case study method. Key informants are assigned as section heads and subdivision heads. In-depth interviews and observation data collection techniques as well as focus group discussions. Data were analyzed using the Miles and Huberman model. The results showed that innovative work behavior did not appear to be evenly carried out by employees. Still limited to section heads and subsection heads. Innovative work behavior can contribute to job effectiveness. Most of the implementing staff have not shown innovative work behavior.
Organizational Culture, Job Satisfaction, Organizational Commitment, and Its Effect on Intention to Leave
Authors: Sumual Tinneke E. M. , Tumbelaka Steven S. X. , Ngantung Fabiola
Published: November 2022

This study has the main goal of being able to analyze and explain how the influence of organizational culture, job satisfaction, and organizational commitment on employee intentions to leave the company, considering that after the covid-19 pandemic, many companies, especially retail companies, have changed their organizational culture. This research is an explanatory research type that uses a positivist approach, with quantitative methods. The data in this study were collected through a list of questionnaires distributed to respondents, and the respondents in this study were employees of three retailer companies in the city of Tomohon, namely: Cool Supermarket, Multimart, and Grand Central, each of which has 100 employees. This study uses the Partial Least Square (PLS) analysis technique. From the analysis results obtained indicate that the organizational culture variable has no significant effect on organizational commitment, but appears to have a significant influence on employee intentions to leave the company, then the resulting analysis obtains an overview that the job satisfaction variable also has a significant influence on commitment. organization, but did not show a significant effect on the desire to leave employees, as well as the organizational commitment variable which did not show a significant effect on the intention to leave employees.
Small Business Empowerment Program Policy in Wajo Regency, South Sulawesi
Authors: Guntur Muhammad , Aslinda Andi , Nur Andi Cudai
Published: November 2022

The study used a quantitative approach involving 175 small business actors. Sampling was carried out by proportional random sampling based on the criteria, namely small entrepreneurs who have registered at the Cooperative Service, UMKM in Wajo Regency, have been in business for 3 years, have retrieved a business license, and have a minimum business capital of IDR 100,000,000. The modelling of the relationship between variables was carried out using a partial least square (PLS) model with Smart PLS software. Small business enablement program policies with business partnerships, strengthening business institutions in connection to the performance of small businesses in Wajo Regency can increase the performance of small businesses of small entrepreneurs. To improve the performance of small businesses, it is need to develop an Institutional Link Enablement of Small Business Model through the cooperation of small entrepreneurs, associations/NGOs, the community, the private sector, the government in this case the UMKM and Cooperatives Service, large entrepreneurs, financial institutions, both banks and non-banks to encourage small entrepreneurs to improve their business performance through business partnerships and strengthening business institutions.
Social Network Analysis Human Resource Development Using Twitter Data
Authors: Jamaluddin  , Saleh Sirajuddin , Salam Rudi , Arhas Sitti Hardiyanti
Published: November 2022

The most important resource owned by an organization, one implication is that the most important investment that an organization may make is in the area of human resources. The purpose of this study was to determine the development of human resources through social network analysis obtained from Twitter data. This research is qualitative netnographic research, with a social network analysis approach known as SNA. The data were obtained and analyzed using the atlas. ti application. The results of the research show that human resource development can be carried out in various ways, such as collaborating with relevant agencies such as the Agency for Personnel and Human Resources Development, or even with other countries. Human Resource Development, more by government agencies than by the private sector. Many of the resource developments are related to technology. This research is new because the analytical media used is new.
Students’ Understanding of Pancasila Ideology (Study at Junior High School in Barru Regency, South Sulawesi Province)
Authors: Akbal Muhammad , Umar Firman , Amin Muhammad , Artina Fitriah , Mustaring
Published: November 2022

The purpose of the study: to find out and to describe (1) students' understanding of Pancasila,(2) students’ attitudes and behaviours about the implementation of Pancasila and (3) students coaching programs in understanding Pancasila values and their attitudes that are following Pancasila values? Research method: quantitative descriptive research. The research location was at Barru Regency Junior High School. This study used the cluster random sampling technique so that the research samples were SMPN 1 Barru, SMPN 2 Barru, SMPN 5 Barru, SMPN 10 Barru, SMPN 18 Barru, SMPN 24 Barru and SMPN 3 SATAP Barru. The total sample of the study was 564 students. Techniques of collecting data were questionnaires, interviews and documentation. The results of the study: (1) The level of students who correctly understood the ideology of Pancasila was 66.50%, (2) The level of students’ understanding of Pancasila values in daily life was 67.51%, (3) school activity programs in fostering students' understanding and attitudes towards Pancasila values including Civics education subjects as the mainstream, flag ceremonies, Intra-School Organizations (OSIS), Scouts, Heritage Flag Hoisting Troop (Paskibra), Youth Red Cross, School Health Unit and other extracurricular activities.
The Deixis Analysis of Disney’s Raya and The Last Dragon Movie Script
Authors: Rokhmah Desy Eva Laila , Tatawalat Selvira , Betaubun Martha
Published: November 2022

This study was on pragmatics, specifically deixis. This study aims to analyze the three main types of deixis: person deixis, time deixis, and place deixis; and to determine the most dominant deixis in the movie entitled Raya and The Last Dragon. The source of the data was the movie script of Raya and The Last Dragon. The data were obtained utilizing documentary techniques. There are 42 scenes in the movie script, and all of them have been studied. Based on the analysis, type of person deixis was used 677 times, including the first, second, and third person. 10 occurrences of spatial/place deixis were found. In addition, the type of temporal/time deixis was used 37 times. The results indicated that person deixis was the most dominant type of deixis in Raya and The Last Dragon's movie script..
The Utilizing of Leftover Wood as a Sit-Up Bench in Developing Fitness Equipment
Authors: Rahail Ronny , Kuswoyo Dilli , Suganda Mikkey
Published: November 2022

The purpose of this research is to develop and produce a sit-up bench as fitness equipment for people in Waninggap Nanggo Village, Semangga District, Merauke which utilize the leftover wood. This method is a development research that refers to the Borg & Gall which has conducted, namely: (1) Conducting Preliminary Research and Gathering Information, (2) Developing Initial Product Forms, (3) Evaluation, (4) Revise First Product, (5) Field trials, (6) Revise Final Product and (7) Final Results through field trial revision. The questionnaire is used in collecting the data; the results obtained were expert evaluation, limited trial, and trial use by the people. Data in the form of production results regarding product quality, product benefits, and its ease. Based on the results of the Physical Education Experts 96.87% (Very Good), through limited trial was 93.75%, and the last one is obtained through trial use was 90%. Based on the data that has been received above, it can be stated that sit-up bench which utilize the leftover wood can be used by the people Waninggap Nanggo Village, Semangga District, Merauke because it can be accepted.
Cooperation Contract for Tourism Destination Managers with Equitable Micro, Small, and Medium Enterprises
Authors: Nugroho Lucky Dafira , Melati Santi Rima , Wahyuliana Ida , Boemiya Helmy
Published: November 2022

Tourism is one of the sources of income that, until now, has become a prima donna. Tourism as a form of the industry has given good advice to the central government, local governments, village governments, the private sector, and the community. In its development, tourist destinations are divided into two forms natural and artificial. Both forms of tourist destinations are located in tourist villages. Tourism development is currently directed at realising tourist villages. Tourist destinations are also equipped with a tourism industry that in it strives to provide all forms of needs needed by tourists, both services and goods. The tourism industry players consist of tourist destination managers and MSME players who sell goods or services. The relationship between tourist destination managers and MSME actors is framed in an agreement made orally based on the principles of trust and needs. This situation tends to cause injustice to MSME actors, who are generally small people. Therefore, solving the problem through a legal breakthrough in regulating business contracts for managing tourist destinations is necessary. The agreement between tourist destination managers and MSME actors is the rule of the game between both parties, which governs rights and obligations. The manufacturing process needs protection from the local government by making regulation yang a reference in managing tourist destinations. Thus, MSME players who are small people are allowed to participate in finding income from the tourism industry in their area by not burdening them.
Recovery of the Tourism Sector after the Covid-19 Pandemic in Merauke Regency
Authors: Lakatompessy Ransta L. , Syahruddin  , Maturbongs Edoardus E. , Jalal Nur , Saragih Dapot P.
Published: November 2022

The Corona Virus Disease (Covid-19) pandemic, which has had a significant impact on changing the world, has resulted in the decline of various aspects of life ranging from economic, social, educational, even daily life, including the tourism sector. The tourism sector in Merauke Regency has also been impacted by the COVID-19 pandemic. This study uses a qualitative research type. The limitation of the analysis in this study is focused on governance collaboration carried out in an effort to restore the tourism sector in Merauke Regency after the covid 19 pandemic. The problem of decreased tourist visits is also due to the lack of promotion of tourism potential. Therefore, it is necessary to have a solid collaboration among tourism stakeholders, as well as policies that regulate such collaboration. Collaboration between fellow actors, namely the government, academia, the private sector, the community and the mass media as a unit that complements each other in efforts to recover the tourism sector after the COVID-19 pandemic.
Reactualization of Employee Creative Behavior in Building the Image of Public Service
Authors: Akib Haedar , Salam Rudi , Basra Jumase , Sanusi Andi Darmawan , Sakawati Herlina
Published: November 2022

The results of this qualitative descriptive study explain the re-actualization of the creative behavior of employees in building the image of public services at the Tourism and Culture Office of Sinjai Regency. The theoretical implication of the re-actualization of human creative behavior – hereinafter referred to as creativity – at the individual level is the basis for developing group creativity in organizations or vice versa. Based on this understanding, the current locus and focus of creativity research are not only limited to the creative behavior of students in the locus of education or schooling, as understood so far but also includes the creativity of all humans in public, private (business) and non-profit organizations. In the study of organizational development, multi-level human creativity is the core (base) of knowledge-based organizational development, the essence, and orientation of the capacity-building program, as well as the basis for efforts to build a satisfying or even happy public service image, both for employees (public service providers). within the organization as well as for citizens or society (service recipients).
Corruption Prevention Through Accountability Mechanism Of State Financial Management In Handling Covid-19 Pandemic
Authors: Suastuti Eny , Hasanah Uswatun , Djulaeka  , Murni  , Cahyani Indah
Published: November 2022

State finance regulations during the Covid -19 pandemic have corruption potential, because the Central oregional Governments have discretion to manage state finance that are create opportunities for authority abuse. The study purpose was to examine state financial regulations during the Covid -19 pandemic that have corruption potential. This research was legal research which was based on the policy to regulate the state finance use during the Covid -19 pandemic. This study used conceptual and statute approaches.The results showed that the enactment of Law Number 2 of 2020 concerning Stipulation of Government Regulations in lieu of Law Number 1 of 2020 is the form of Government seriousness to save the national health and economy. However, granting authority and discretion to the central or regional government to use state finance if without proper supervision, control and examination, there is potential for authority abuse. Supervision is the main task of central government, if the supervisory function is not good in the process of proposing the Covid -19 budget, this will create difficulties, which will provide opportunities for corruption.
Development of Social Capital as a Trigger of Agro-tourism Economy in Horticultural Farming Communities in Rurukan Village
Authors: Santie Yoseph D. A. , Fathimah Siti , Mesra Romi
Published: November 2022

The research starts from an understanding of how the concept of social capital can be applied in an effort to accelerate the improvement of community empowerment as one of the important steps to achieve successful development in the economic field. The research method used is descriptive qualitative method with research model referring to the theory of Miles and Huberman, with stages starting from data collection,data classification, data presentation, and data verification or drawing conclusions. The results of this study are the development of social capital in supporting agro-tourism economic activities can be applied in the horticultural farming community in Rurukan Village through the application of elements of social capital,namely elements of social networks; reciprocity or the exchange of kindness, with the exchange of kindness by maintaining social networks, of course, being able to foster harmonious relationships so that this agrotourism activity can be remembered beautifully and peacefully. This of course must be patterned and run continuously so as to form a pattern of social norms so that these rules can be a reference for the community,which are then poured into good values and realized by proactive actions in implementing all elements of social capital.
Development of Hot Springs Tourism Site in Lehi Village North West Siau District Sitaro Regency
Authors: Bogar Wilson
Published: November 2022

The research was carried out with the aim of analyzing and explaining the development of Hot Springs Tourism Site in Lehi Village, North West Siau District, Sitaro Islands Regency. This study uses a qualitative approach with the research subjects being the Head of Division and Head of the Tourism Promotion and Marketing Section of the Tourism Office, Sitaro Islands Regency as the main data source (key informant), while other informants are determined by snowball sampling. The research instrument is the researcher himself with interview and documentation techniques. The data analysis technique used qualitative analysis according to the interactive model, namely data reduction, data display, and conclusion drawing/verification. The results show that the development of hot spring tourism site in Lehi village is integrated with the Sitaro Islands Regency tourism development program in Master Plan for Regency tourism development (RIPPDA) the Sitaro Islands Regency in 2020-2025 which includes tourism industry development, tourism destination development, tourism marketing development, and tourism institutional development. For this reason, coordination and synchronization with all stakeholders are carried out intensively so that synergies occur in the whole process and activity of developing tourism objects.
Mitarbeitende langfristig binden – Wissenschaft nachgefragt
Authors: Veit Katrin
Published: November 2022

Physiotherapeutin Helena Klingler hat sich dem Thema Fachkräftemangel von einem ganz anderen Blickwinkel aus genähert. In ihrer Bachelorarbeit beschäftigte sie sich mit den Auswirkungen von Employer Branding. Eine unternehmensstrategische Maßnahme, um sich als Arbeitgeber attraktiv aufzustellen.
Exogen bedingte Retinopathien
Authors: Kellner Ulrich , Kellner Simone , Weinitz Silke , Farmand Ghazaleh
Published: November 2022

Exogen bedingte Retinopathien werden am häufigsten durch externe Stimulanzien, seltener durch unerwünschte Arzneimittelwirkungen systemisch oder intravitreal eingesetzter Medikamente und
noch seltener durch Impfungen oder die Einwirkung von Lichtstrahlung verursacht. Die Kenntnis exogener Ursachen und ihre mögliche Symptomatik ist zur Prophylaxe oder zur Früherkennung
schädigender Wirkungen und zur adäquaten Beratung der Patienten wichtig.
Mitochondrial Transplantation Therapy against Ifosfamide Induced Toxicity on Rat Renal Proximal Tubular Cells
Authors: Arjmand Abdollah , Mashhadi Melika , Kaveh Armin , Kamranfar Farzaneh , Seydi Enayatollah , Pourahmad Jalal
Published: November 2022

Mitochondrial dysfunction is a basic mechanism leading to drug nephrotoxicity. Replacement of defective mitochondria with freshly isolated mitochondria is potentially a comprehensive tool to inhibit cytotoxicity induced by ifosfamide on renal proximal tubular cells (RPTCs). We hypothesize that the direct exposure of freshly isolated mitochondria into RPTCs affected by ifosfamide might restore mitochondrial function and reduce cytotoxicity. So, the aim of this study was to assess the protective effect of freshly isolated mitochondrial transplantation against ifosfamide-induced cytotoxicity in RPTCs. Therefore, the suspension of rat RPTCs (106 cells/ml) in Earle’s solution with the pH of 7.4 at 37°C was incubated for 2 h after ifosfamide (4 mM) addition. Fresh mitochondria were isolated from the rat kidney and diluted to the needed concentrations at 4°C. The media containing suspended RPTCs was replaced with mitochondrial-supplemented media, which was exposed to cells for 4 hours in flasks-rotating in a water bath at 37°C. Statistical analysis demonstrated that mitochondrial administration reduced cytotoxicity, lipid peroxidation (LPO), reactive oxygen species (ROS) production, mitochondrial membrane potential (MMP) collapse, lysosomal membrane damage, extracellular oxidized glutathione (GSSG) level, and caspase-3 activity induced by ifosfamide in rat RPTCs. Moreover, mitochondrial transplantation increased the intracellular reduced glutathione (GSH) level in RPTCs affected by ifosfamide. According to the current study, mitochondrial transplantation is a promising therapeutic method in xenobiotic-caused nephrotoxicity pending successful complementary in vivo and clinical studies.
Pachychoroidale Erkrankungen
Authors: Faatz Henrik , Lommatzsch Albrecht
Published: November 2022

Pachychoroidale Erkrankungen umfassen eine Gruppe von Erkrankungen, die charakteristische choroidale Merkmale zeigen. Diese können heutzutage durch multimodale Bildgebung immer
differenzierter beschrieben werden und umfassen fokale oder diffuse Aderhautverdickungen mit erweiterten und hyperpermeablen choroidalen Gefäßen. Die richtige Diagnose und Abgrenzung von
anderen exsudativen Erkrankungen ist für eine mögliche Therapie von großer Bedeutung.
Robust and Scalable Reductive Amination Protocol for Electron-Poor Heterocyclic Amines Using Et3SiH/TFA as Reducing Agent
Authors: Schäfer Gabriel , Reber Stefan , Ahmetovic Muhamed , Fleischer Tony , Leuenberger Daniel , Blumer Nicole , Udry Megan , Abele Stefan
Published: November 2022

A facile reductive amination procedure for electron-poor heterocyclic amines with aromatic and aliphatic aldehydes has been developed. The key to success was the use of triethylsilane (Et3SiH) as reducing agent, in combination with trifluoroacetic acid (TFA) in refluxing CH2Cl2. The reductive aminations are fast and clean, and allow for the isolation of the alkylated amines in high yields and purity after crystallization or chromatographic purification. The robustness and scalability of the process has been demonstrated for one substrate combination on 750 g scale, leading to the isolation of the corresponding product in 93% yield.
An Asymmetric Total Synthesis of Picrotoxinin through a Mizoroki–Heck Reaction
Authors: Nakazaki Atsuo , Matsumura Taishi , Nishikawa Toshio
Published: November 2022

An asymmetric total synthesis of picrotoxinin was performed by using a Mizoroki–Heck reaction of an enantioenriched tricyclic lactone with isopropenyl bromide as a key transformation, permitting the highly diastereoselective introduction of the requisite C4-isopropenyl group. After functional-group manipulations, including carbonylation, bromoetherification, epoxidation, and dihydroxylation, picrotoxinin was obtained in a moderate to good yield.
Primary Prevention of Ischemic Stroke
Authors: Sabayan Behnam
Published: November 2022

Ischemic stroke is by far the most common type of cerebrovascular event and remains a major cause of death and disability globally. Despite advancements in acute stroke care, primary prevention is still the most cost-effective approach in reducing the burden of ischemic stroke. The two main strategies for primary stroke prevention include population-wide versus high-risk group interventions. Interventions such as increasing access to primary care, regulation of salt and sugar contents in processed foods, public education, and campaigns to control cerebrovascular risk factors are examples of population-wide interventions. High-risk group interventions, on the other hand, focus on recognition of individuals at risk and aim to modify risk factors in a timely and multifaceted manner. This article provides an overview on conventional modifiable risk factors for ischemic stroke and highlights the emerging risk factors and approaches for high-risk group identification and treatment.
The system-wide effects of dispatch, response and operational performance on emergency medical services during Covid-19
Authors: Pitt Ivan L.
Published: November 2022

In this paper, we analyze the Fire Department of New York City’s pre-hospital emergency medical services dispatch data for the period of March 20, 2019–June 13, 2019, and the corresponding Covid lockdown period of March 20, 2020–June 13, 2020. A fixed effects negative binomial model is used to estimate the heterogeneity effects of average ambulance travel or response times on the daily volume of emergency calls, year, day of the week, dispatcher-assigned medical emergency call type, priority rank, ambulance crew response, borough and an offset for missing calls. We also address the limitations of other non-parametric Covid studies or parametric studies that did not properly account for over-dispersion. When our model is estimated and corrected for clustered standard errors, fixed effects, and over-dispersion, we found that Wednesday was the only day of the week that was most likely to increase travel response time with an odd ratio of 6.91%. All grouped call types that were categorized showed significant declines in average travel time, except for call types designated as allergy and an odds ratio of 21.81%. When compared to Manhattan, Staten Island ambulance response times increased with an odds ratio of 19.05% while the Bronx showed a significant decline with an odds ratio of 31.92% advanced life support (ALS) and BLS ambulances showed the biggest declines in travel time with the exception of BLS assigned ambulance types and emergency priority rank of 6. Surprisingly, in terms of capacity utilization, the dispatch system was not as overwhelmed as previously predicted as emergency call volume declined by 8.83% year over year.