bluuebunny/crossref_metadata_2025 huggingface dataset:
TiO2 nanotubes film/FTO glass interface: Thermal treatment effects
Authors: Vujancevic Jelena , Bjelajac Andjelika , Veltruska Katerina , Matolin Vladimir , Siketic Zdravko , Provatas Georgios , Jaksic Milko , Stan George , Socol Gabriel , Mihailescu Ion , Pavlovic Vladimir , Janackovic Djordje
Published: July 2022

Pure Ti films deposited by radio-frequency magnetron sputtering on FTO glass
were anodized to fabricate TiO2 nanotubes (NTs) arrays. The TiO2 NTs/FTO
samples were sintered at 450, 550 and 630?C, in ambient air. The thermal
treatment did not influence the crystal phase composition, preserving in all
cases the anatase single phase. As expected, the crystalline anatase quality
improved with the annealing temperature. Nevertheless, slight differences in
nanotubular morphology, such as the appearance of grains inside the walls,
were observed in the case of the sample sintered at 630?C. Chemical
analysis by X-ray Photoelectron Spectroscopy of annealed samples revealed
the presence of Sn inside TiO2 NTs, due to diffusion of Sn from the
substrate to TiO2. For the substrate was used FTO glass whose top layer
consists of SnO2 doped with F. Rutherford Backscattering Spectrometry and
Time-of-Flight Elastic Recoil Detection Analysis were carried out to study
the elemental depth profile of the films. It was found that the temperature
of sintering controls the Sn diffusion inside TiO2 film. Sn atoms diffuse
towards the TiO2 NTs surface for the samples annealed at 450 and 550?C. The
diffusion is however hindered in the case of the heat treatment at 630?C.
Besides, the Ti diffusion into the SnO2 underlayer was observed, together
with the formation of TiO2/SnO2 interfaces. One then expected but not a
great difference in absorption between samples, since all contained anatase
phase, as confirmed by Diffuse Reflectance Spectroscopy. A higher amount of
Sn was however detected for the sample annealed at 550?C, which accounts for
a slight red absorption shift. The importance of controlling the annealing
parameters of the anodized TiO2/FTO structures was highlighted through the
formation of TiO2-SnO2 interfaces and the Sn insertion from FTO, which can
play an essential role in increasing the photoperformances of TiO2 NTs/FTO
based structures of photovoltaic cells.
Phishing as a form of fraud identity theft in healthcare: Victimization during COVID-19 pandemic
Authors: Vilic Vida
Published: July 2022

The coronavirus pandemic affects all segments of human life around the world.
Due to the risk to people's health, personal communication has been
completely changed and most professional activities and contacts must take
place in a cyber environment, with the help of computers and mobile
telephony. On-line communication and the use of social networks undoubtedly
represent a conditio sine qua non in a situation when compliance with
numerous preventive measures are required, including the work from home,
online teaching in schools, a ban on gatherings etc. The positive aspects of
this kind of communication are undoubtedly obvious and necessary, but they
also created new forms of victimization due to insecure protocols for
sending e-mails, inadequate level of privacy protection, insufficient
information security, the existence of so-called security holes and the use
of the same devices and digital services for professional and private
purposes. Hacking phishing activities during the pandemic mostly endangered
the security of confidential data collected within medical information
systems, educational institutions, and in the field of banking, when the
user is expected to compromise his/her digital identity and publish his/her
data. The subject of this paper is the presentation of some of the most
common phishing activities and identity theft in the field of health care,
provision of health services, procurement of medicines and vaccines against
coronavirus, which have been recorded in the world since the beginning of
the pandemic. The phishing activities that will be presented in this paper
significantly contribute to the further spread of panic from the misuse of
medical data of infected persons and their contacts. The paper aims to point
out the most common forms of victimization that have appeared around the
world, as a consequence of cyber security violations due to hacker attacks
during the COVID- 19 pandemic. Special emphasis in the paper is on these
?pandemic? cyber dangers, as well as on the mechanisms for avoiding this
type of victimization.
Solving Capacitated Vehicle Routing Problem Using Football Game Algorithm
Authors: Alif Alfian , Garside Annisa Kesy , Amallynda Ikhlasul , Ramadhani Baiq Nurul Izzah Farida
Published: July 2022

The Capacitated Vehicle Routing Problem (CVRP) plays an important role in the logistics transportation sector. Determining the proper route will reduce the company's operational costs. In CVRP, a number of vehicles have a capacity limit that can serve all customers. This research completes a real case study on a bottled drinking water company where the company still uses the subjective method of the driver to determine the transportation route. Based on the conditions in the company, the selection of the best route will consider vehicle capacity and demand to determine the shortest route. The execution of this case study uses the Football Game Algorithm (FGA) which was first initiated by Fadakar Ebrahimi which proved promising and had the strongest performance in all cases. FGA is expected to be able to determine the shortest distribution route from the existing cases to reduce the distribution costs incurred. This study takes data from 4 days of delivery that served 78 customers. The average daily transportation cost savings result is 42%. This amount indicates that the FGA algorithm is effective for completing a real case study in CVRP.
An Energy-Efficient No Idle Permutations Flow Shop Scheduling Problem Using Grey Wolf Optimizer Algorithm
Authors: Al-Imron Cynthia Novel , Utama Dana Marsetiya , Dewi Shanty Kusuma
Published: July 2022

Energy consumption has become a significant issue in businesses. It is known that the industrial sector has consumed nearly half of the world's total energy consumption in some cases. This research aims to propose the Grey Wolf Optimizer (GWO) algorithm to minimize energy consumption in the No Idle Permutations Flowshop Problem (NIPFP). The GWO algorithm has four phases: initial population initialization, implementation of the Large Rank Value (LRV), grey wolf exploration, and exploitation. To determine the level of machine energy consumption, this study uses three different speed levels. To investigate this problem, 9 cases were used. The experiments show that it produces a massive amount of energy when a job is processed fast. Energy consumption is lower when machining at a slower speed. The performance of the GWO algorithm has been compared to that of the Cuckoo Search (CS) algorithm in several experiments. In tests, the Grey Wolf Optimizer (GWO) outperforms the Cuckoo Search (CS) algorithm.
Forecasting Database Usage During the Height of COVID-19
Authors: Sharpe Chris , Evans David
Published: July 2022

As with other catastrophic events, the COVID-19 pandemic disrupted higher education and library services. The authors examine the effect of the COVID-19 pandemic on usage of health databases in 2020. They use time series analysis to create a forecast based on previous years’ activities, and then compare it with actual database usage during the pandemic. The results show an initial increase in searches for the first full month of the pandemic, but then match the expected forecast data and decrease during summer and early fall months. The authors conclude that time series analysis is a useful tool for understanding the impact of events and for planning purposes.
Starting a New Midcareer Librarian Position During COVID-19
Authors: Bomberger Rachel , Yesilbas Amanda
Published: July 2022

This article chronicles the experience of two midcareer librarians who were new hires at the University of South Florida one month before the entire campus was sent to work from home due to the COVID-19 pandemic. They recount the obstacles encountered and how they overcame them. They include lessons learned and ways to improve a transition to remote working. Specific areas that are discussed: technology, training, communication, self-advocacy, relationship building, and mentorship.
From Herland to Gilead: Framing Post-Feminine Fertility in Dystopian and Utopian Fiction
Authors: Casibual Joseph Padios
Published: July 2022

There is something structurally amiss in a culture that only values women for their capacity to bear a child which is reflected in misrepresentations in literature that confined women to stereotypes that creates an endless room for debate as to what future is in store for women particularly in post-humanist literature. This paper addresses how female fertility is framed in the texts of Margaret Atwood- The Handmaid’s Tale and The Testaments (dystopian) and Charlotte Perkins Gilman- Herland and With Her in Ourland (utopian). Using transitivity analysis, it aims to examine representation and roles attached to feminine fertility, to discourse fertility in utopian and dystopian texts, and evaluate the politics of the female body in relation to fertility and reproduction. Clearly, Atwood’s dystopian fiction critically examined the oppressive and utilitarian view towards the female body which contrasted with Gilman’s utopic body autonomy. It is revealed that a sense of feminine liberty is associated with utopian fiction contrary to body bondage depicted in dystopian texts which have deeply elaborated a politicized view towards the future of the post-female body and women in general.
Nikolau Syndrome: Necrotic Activity of Drugs and Ways to Prevent Post-Injection Abscesses (In memory of Professor László A Gömze)
Authors: Urakov A. L.
Published: July 2022

Post-injection abscess, which is the sad finale of Nicolau syndrome, continues to attract the attention of researchers due to the need to clarify the causes of this iatrogenic disease in order to develop effective measures for its prevention. For many years, researchers from all over the world have tried from different perspectives to explain the mechanism of the drugs effect that causes post-injection pain syndrome, infiltration, inflammation, erimatous skin damage, necrosis and abscess (Nicolau syndrome), but to no avail. This has been done only in recent years. There are findings in Russia that show that drugs considered to be of high quality today, in some cases, in addition to specific pharmacological activity, may have necrotic activity of a non-specific nature of action. The findings showed that according to the established pharmaceutical practice and in full compliance with the pharmacopoeia requirements for the quality of medicines, pharmaceutical products produced by different pharmaceutical companies, as well as those included in different series of the same pharmaceutical company, may have different compositions (formulations), contain different ingredients, therefore they may have different physico-chemical properties. In this regard, drugs of different serial numbers and/or different manufacturers, which are considered high-quality today, can be hypertonic solutions, have acidifying or alkalizing activity, have alcohols, aldehydes and heavy metal salts in denaturing concentrations. This is the reason that in some cases drugs have necrotic (cauterizing) activity. In this regard, to prevent Nicolau syndrome, it is proposed to reduce the physico-chemical aggressiveness of drugs. Today, this can be done successfully by diluting them with water for injection 2 to 8 times before injection.
Surgical Aid to Patients with Hepatopancreatobiliary Situations in Precovid Period and under Persistent Relapse of New Coronavirus Infection SARS-CoV-2
Authors: Nartaylakov M. A. , Panteleev V. S. , Salimgareev I. Z. , Loginov M. O. , Zolotukhin K. N. , Dorofeev V. D. , Mirasova G. Kh. , Shakurov D. F. , Petrov A. S.
Published: July 2022

Introduction. The third wave of the new coronavirus infection (COVID-19) pandemic warrants total mobilisation of healthcare and social resources. In this respect, a pressing issue remains the provision of routine and emergency surgical care in patients with hepatopancreatobiliary diseases.

Materials and methods. A retrospective analysis of the surgical outcomes in 5,040 hepatopancreatobiliary patients was carried out; this accounted for 51.1 % of the total abdominal surgeries.

Results and discussion. Biliary lithiasis and its complications — choledocholithiasis with obstructive jaundice and residual choledocholithiasis — (54.4 %) as well as acute calculous cholecystitis (18.7 %) were operated most frequently. A sharp decrease over all hepatopancreatobiliary nosologies was registered for the surgical interventions in first pandemic year 2020. Thus, the median annual number of operations for biliary lithiasis and its complications was 550 (482–592 year-range) in the precovid period, while dropping to only 321 at the onset of pandemic (p <0.05). A first sixmonth survey of year 2021 revealed a growth of surgical activity for all hepatopancreatobiliary nosologies.

Conclusion. Hepatopancreatobiliary operations prevail (54.4 % cases) in the total structure of level 3 abdominal surgical interventions. A high annual rate of surgical operations over nearly all hepatopancreatobiliary nosologies was interrupted in the first year of the new coronavirus infection outbreak. Meanwhile, the first half of 2021 showed a clear tend towards restoring the precovid statistical indicators, despite the stressful conditions of persistently relapsing COVID-19 that surgical facilities had faced.
RANCANGAN BANGUN GAME EDUKASI TEBAK GAMBAR BAGI SISWA SMPLB INSAN MADANI METRO
Authors: Mayasari Yunitas , Mustika Mustika , Sutanti Asih
Published: July 2022

Game Edukasi Adalah permainan yang dirancang atau dibuat untuk merangsang daya pikir termasuk meningkatkan konsentrasi dan memecahkan masalah. Media pembelajaran yang digunakan guru SMPLB di SLB Insan Madani Metro saat ini adalah menggunakan Media Flash Card. Guru membuat Flash Card sendiri sesuai dengan materi pembelajaran yang diajarkan, kelemahannya gambar dapat rusak atau hilang, kurang menarik dan membosankan bagi peserta didik bagi siswa SMPLB yang mempunyai emosional tinggi. Tujuan penelitian adalah melakukan inovasi media pembelajaran dalam bentuk game edukasi, serta membuat game edukasi tebak gambar bagi siswa SMPLB Insan Madani Metro. Metode penelitian yang digunakan yaitu metode berdasarkan jenis penelitian (Applied Research) dengan teknik pengumpulan data pengamatan, wawancara, dokumentasi dan studi pustaka. Metode pengembangan aplikasi menggunakan SDLC (System Development Life Cycle) dengan teknik pengujian menggunakan Black Box Testing. Bahasa pemrograman yang digunakan adalah Java NetBeans, dengan database MySQL. Game yang dihasilkan memiliki kelebihan tersedianya Button Help atau bantuan untuk membantu guru dalam menyampaikan petunjuk penggunaan game, terdapat fitur-fitur gambar yang menarik dan berwarna, sebagai media pembelajaran yang moder dengan berbasis teknologi, dibuat lebih simple agar siswa lebih mudah memahami metri pembelajaran.
APLIKASI PERPUSTAKAAN BERBASIS DESKTOP PADA SMK KARTIKATAMA 1 METRO
Authors: Dariyanto Dariyanto , Hidayat Arif , Irawan Dedi
Published: July 2022

Permasalahan yang ditemui selama melakukan penelitian, yaitu belum terkomputerisasinya sistem pelayanan perpustakaan seperti peminjaman buku, dan pengembalian buku, masih di catat dalam bentuk pembukuan sedangkan pecarian data buku juga masih manual yang memakan waktu lama. Pelayanan yang masih menggunakan proses manual maka akan menimbulkan lambatnya kerja perpustakaan yang mengakibatkan tidak kepuasan bagi siswa siswi terhadap pelayanan perpustakaan. Tujuan dari penelitian yang dilakukan pada SMK Kartikatama 1 Metro adalah untuk membuat aplikasi perpustakaan berbasis desktop di SMK Kartikatama 1 Metro sehingga dapat memudahkan petugas perpustakaan. Metode penelitian yang digunakan oleh peneliti terdiri dari dua bagian, yaitu metode berdasarkan jenis penelitian (Applied Research) dan teknik pengumpulan data pengamatan (observasi), wawancara (interview), dokumentasi (documentation) dan studi kepustakaan (library research). Aplikasi dirancang menggunakan pendekatan pemrograman terstruktur yang berbasis desktop. Metode pengembangan aplikasi menggunakan SDLC (System Development Life Cycle) dengan teknik pengujian aplikasi menggunakan teknik Black Box Testing. Bahasa pemrograman yang digunakan adalah Java Netbeans, dengan database MySQL dan report menggunakan Quickreport. Alat pengembangan sistem yang digunakan antara lain flowchart, diagram konteks, dfd, erd, dan flowchart. Hasil dari penelitian adalah sebuah Aplikasi Perpustakaan Berbasis Desktop pada SMK Kartikatama 1 Metro
APLIKASI PENGOLAHAN DATA PERPUSTAKAAN SLB INSAN MADANI METRO
Authors: Nurdiansyah Ikhwan , Sudarmaji Sudarmaji , Sutanti Asih
Published: July 2022

Aplikasi pengolahan data perpustakaan Adalah aplikasi yang dirancang atau dibuat untuk mempercepat suatu pekerjaan supaya lebih efisien dan memecahkan masalah. Berdasarkan penelitian yang dilakukan, diperoleh informasi bahwa media penyimpanan yang digunakan staf perpustakaan di SLB Insan Madani Metro saat ini adalah dengan menggunakan penulisan manual menggunakan buku besar. Kelemahannya adalah dalam pengarsipan buku ini kurang efektif karena bisa terjadi kerusakan atau kehilangan buku besar kesulitan dalam pencarian data perpustakan untuk pembuatan laporan jumlah dan macam-macam buku apa saja yang ada pada perpustakaan. Hal ini tentunya akan memperlambat suatu pekerjaan yang harusnya bisa lebih cepat dikerjakan. Tujuan dari penelitian yang dilakukan pada SLB Insan Madani Metro adalah untuk membuat media penyimpanan data buku perpustakaan, serta untuk memper mudah membuat laporan perpustakaan SLB Insan Madani Metro. Metode penelitian yang digunakan oleh penulis terdiri dari dua bagian, yaitu metode berdasarkan jenis penelitian (Applied Research) dan teknik pengumpulan data pengamatan (observasi), wawancara (interview), dokumentasi (documentation) dan studi kepustakaan (library research). Metode pengembangan aplikasi menggunakan SDLC (System Development Life Cycle) dengan teknik pengujian aplikasi menggunakan teknik Black Box Testing. Bahasa pemrograman yang digunakan adalah Java NetBeans, dengan database MySQL. Alat pengembangan sistem yang digunakan antara lain flowchart, diagram konteks, dfd, dan flowchart. Berdasarkan permasalahan tersebut, maka dibutuhkan sebuah aplikasi pengolahan data yang dapat membantu proses penyimpanan.
Curvilinear element of the discontinuous Galerkin method designed to capture the labyrinth seal geometry exactly
Authors: Bublík Ondřej , Pecka Aleš , Vimmr Jan
Published: July 2022

The present study applies the discontinuous Galerkin finite element method to a numerical simulation of a compressible fluid flow through a labyrinth seal. This paper is proposes a curvilinear hexahedral element, which is deformed in such a way that it matches the rotated walls of the labyrinth seal exactly. A numerical study is performed on the staggered labyrinth seal with two teeth on the rotor and one tooth on the stator. For numerical simulation, three computational meshes with different refinement are considered. All of the numerical simulations are performed for both stationary rotor and for rotor rotating at 50 Hz. The obtained numerical results are compared with results computed by the commercial CFD software Ansys Fluent.
Konsep GHOST- CAP untuk Proteksi Otak Perioperatif pada Cedera Otak Traumatik
Authors:   Department of Anesthesiology and Intensive Care, Faculty of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital Bandung, Indonesia, Yulianti Bisri Dewi , Bisri Tatang ,   Department of Anesthesiology and Intensive Care, Faculty of Medicine Universitas Jenderal Achmad Yani/Melinda International Hospital Bandung, Indonesia
Published: July 2022

Brain damage is an injury that causes damage or worsening of brain cells caused by various conditions such as head trauma, inadequate oxygen supply, infection or intracranial hemorrhage. Brain protection is a preemptive measure of therapeutic interventions to improve neurological outcomes in patients at risk of cerebral ischemic, while brain resuscitation refers to therapeutic interventions that begin after the occurrence of ischemic. The target is ischemic therapy and reducing neuronal injury. Perioperative brain damage is one of the most serious adverse complications of surgery and anesthesia, resulting in new postoperative neurological deficits. The concept of GHOST-CAP, an acronym for Glycemia, Hemoglobin, Oxygen, Sodium, Temperature, Comfort, Arterial Pressure and PaCO2, can be used in the postoperative period. G: The target level of glucose is between 80 and 180 mg/dL. H: hemoglobin threshold is 7-9 g/dL. O: oxygen, target SpO2 between 94 and 97%. S: Sodium concentration affects brain volume, sodium levels up to 155 mEq/L are tolerable. T: temperatures regulated to optimize cellular function, but core temperatures > 38.0°C should be avoided. C: patient comfort, including pain control, agitation, anxiety, and chills. A: Arterial blood pressure is the main determinant of cerebral blood flow (CBF), maintaining an mean arterial pressure (MAP) of 80 mmHg and cerebral perfusion pressure (CPP) of 60 mmHg. P: Acute changes in PaCO2 cause CBF changes, PaCO2 not to be less than 35 mmHg. This paper examines the GHOST-CAP concept for perioperative brain protection, whether adequate or should be supplemented
Penatalaksanaan Anestesi Tindakan Bedah Endoskopi Evakuasi Perdarahan Intraserebral karena Stroke Hemoragik
Authors:   Department of Anesthesiology and Intensive Care, Faculty of Medicine Universitas Udayana/Sanglah General Hospital Bali Indonesia, Pramana Suarjaya I Putu , Krisna J Sutawan Ida Bagus , Aris Sugiharso Muhammad
Published: July 2022

Medical conservative treatment is a mainstay of supratentorial intracerebral hemorrhage management, which include blood pressure and increased intracranial pressure management, as well as seizure and thromboembolic prevention. Surgical intervention is an option if the intracerebral hematoma is expanding significantly and increase morbidity and mortality. Neuroendoscopic procedure is an attractive option which is less invasive and also provides high hemorrhage evacuation rate, low incidence of complication, better protection of brain tissue, and fever surgery-related injuries compared to open craniotomy. In this report, we presented a case of a man 44 years old, obese with body mass index of 36.73 kg/m2, hypertensive, who suffered from intracerebral hemorrhage and underwent endoscopic intracerebral blood clot evacuation. Medical management was done and the patient regained full consciousness, with left hemiparesis and the left supranuclear nerve VII sequelae. Due to the expanding volume of the hematoma, the patient underwent endoscopic surgical blood clot evacuation. Minimally invasive intracerebral blood clot evacuation of expanding hemorrhagic stroke in patient gives the anesthesiologist enormous challenge during the perioperative periods to provide optimal surgical conditions, performing brain protection, and ensure patients have early excellent recovery.
Design of measuring flow velocity device for liquid fluid with venturi meter principles based on Arduino
Authors: Perdana Rendi Hadi , Wibowo Nur Aji , Ayub Made R. S. S. N.
Published: July 2022

Fluid flow velocity in physics can be found on the principle of venturi meter. The Fluid flow concept is easy to understand if visualized. We need a learning media of fluid velocity, so the concept can understanding. Design of this tool aims to help students understand the fluid flow velocity. Data is taken automatically by Arduino-based water flow sensor, with speed change at the speed knop. Based on the design result of the tool which can be obtained by measuring the fluid flow velocity at a speed greater than 0.36 m/s, and proved by graph analysis logarithmic between velocity values of magnitude theory (Vtheory = 0.5x + 0.7934 m/s ) and tool speed (Vtool = 0.5825x + 1.129 m/s). The speed difference between the theory and the tool indicates the magnitude of the frictional speed due to the turbulent flow. So it can be concluded the design of this tool can be used as a learning media  to help students in understanding the topic of fluid.
Extraction and characterization of algal oil from Lake Sebu, South Cotabato
Authors: Larida Alvin Q. , Bañaga Jaeven B.
Published: July 2022

Algae is rich in storage lipids and fats that can be converted into biodiesel. This study determined the algal oil from Lake Sebu, South Cotabato as biodiesel source. Samples were prepared at varying treatments and ratio with n-Hexane. The algal oil was extracted and efficiency % were determined.  FFA% and Acid Number of the oil extract were identified using chemical titration. FTIR was used for Chemical characterization while GC-MS identified fatty acid and other organics. With the constant volume of solvent and by changing the mass of dried algae, the percent yield of oil increases as the solvent to algae ratio increases.  Therefore, biomass ratio with n-Hexane should be 1:3. The IR spectra of the oil extract indicated the presence of functional groups such as amine and carbonyl group of amides, methylene, methyl, and alkene. While, GC-MS showed that the fatty acids found can be a potential biodiesel.
Impact of transdermal flunixin administration on serum prostaglandin E2 and cortisol concentrations in piglets following castration
Authors: Merenda Victoria R. , Wagner Brooklyn K. , Arruda Andréia G. , Lopez Soriano Magdiél , Montgomery Shawnee , Coetzee Johann F. , Pairis-Garcia Monique D.
Published: July 2022

OBJECTIVE

To assess the effects of transdermal flunixin administration on serum prostaglandin E2 (PGE2) and cortisol concentrations in piglets undergoing castration.

ANIMALS

104 litters with at least 4 male piglets/litter.

PROCEDURES

Litters were randomly assigned to 1 of 4 treatments: transdermal flunixin (3.33 mg/kg) administration followed by surgical castration (CF; n = 28), transdermal flunixin administration followed by sham castration (SF; n = 26), application of physiologic saline solution followed by sham castration (S; n = 26), and application of physiologic saline solution followed by surgical castration (C; n = 24). Blood samples were collected 24 hours before and 1, 4, and 25 hours after castration or sham castration.

RESULTS

Serum PGE2 concentrations for piglets in the C and CF groups did not differ at any time. Piglets in the S group tended to have higher serum PGE2 concentrations 1 hour after sham castration compared with piglets in the SF group. One hour after the procedure, piglets that underwent castration had higher serum cortisol concentrations than did piglets that underwent sham castration. Piglets in the CF group had higher serum cortisol concentrations than did piglets in the SF group 4 hours after the procedure, but serum cortisol concentrations did not differ between the C and S groups.

CLINICAL RELEVANCE

Further studies are needed to explore dosing regimens, including effective doses and administration frequencies, and the pharmacokinetics of flunixin following transdermal administration in piglets undergoing castration.
Case Study – A Comparative Analysis of Two Scenarios of a RC Frame Structural System for a Duplex House
Authors: Țăranu George
Published: July 2022

The paper presents the comparative analyses in terms of dynamic behavior of two scenarios of an RC frame structural system for a duplex house situated in Neamt, Romania a seismic zone with PGA 0.25g. The study shows the structural behavior in terms of vibration modes, horizontal displacements and efforts. The conclusions offer the best argument to chose the preferred structural system by owner.
Bio-Cementation: An Eco-Friendly Solution to Reduce the Water Infiltrations in Hidrotechnical Concrete Elements
Authors: Cătălin Sbîrlea , Nicolina Isopescu Dorina , Dragoş Ungureanu , George Maxineasa Sebastian , Răzvan-Andrei Polcovnicu
Published: July 2022

The bio-cementation repairing technique consists in using a bio product which precipitates in a porous environment and thus, filling the internal voids. In the construction industry, there is a series of applications for this repairing technology, mainly for cementitious materials. In this respect, the calcium carbonate-based materials are considered to be the most suitable bio products since they are compatible with a wide range of concrete mixes.

This paper presents a method of manufacturing a calcium carbonate bio product, using a device designed and manufactured exclusively for this experimental work. In order to design a bio product with an unique set of properties, various preliminary samples, obtained by varying the material quantities, the preparation time and working temperatures, have been tested. The bio product analyzed in this work may increase the impermeability of mortar and concrete elements, by continuous sealing of microcracks that can occur throughout the life cycle of the members. Thus, since this bio product was meant to be a component of the mortar/concrete mixture, the mechanical properties were determined by testing several mortar samples made with different cement-bio product ratios.
On the Seismic Resilience of Interwar Buildings
Authors: Gruia Liviu-Costin
Published: July 2022

This paper deals with multi-story buildings erected mostly in interwar period in seismic areas and designed for gravitational actions only. The typical structural system is reinforced concrete frames and masonry infills. A usual multi-story interwar structure was chosen in order to evaluate its seismic resilience. There were made in situ measurements for its dynamic characteristics. The numerical model was calibrated according to in situ measurements. There were proposed two methods of increasing the seismic resilience. First method consists in improving the resilience by reshaping without reinforcing. The second method is additional to the first. It consists in reinforcing infilled frames in order to take over seismic loads.
Sinonasal malignant melanoma
Authors: Birta Daiana , Blaj Simona , Terteci-Popescu Dragos , Avram Emil , Tiple Cristina , Chirila Magdalena , Ungureanu Andrei , Zahu Renata
Published: July 2022

Sinonasal malignant melanoma is a rare, aggressive tumor, associated with a poor prognosis, accounting for 8-15% of all head and neck melanomas and 0.5-2% of all melanomas. The diagnosis is given by histopathological and immunological examination. Elective treatment consists of surgical excision with free resection borders, and adjuvant chemotherapy / radiotherapy / immunotherapy / checkpoint inhibitors can be used to control local recurrence and distant metastases. We chose to present the case of an unresectable ethmoidal malignant melanoma at the time of diagnosis, pembrolizumab treatment converting it to resectability, with improving patient’s quality of life, even if the patient developed an adrenal metastasis.
Extramedullary plasmacytoma of the nasal cavity with kappa light chains in a young person: A case report
Authors: Hammoud Zakaria Chekh , Benmansour Najib , Ouahidi Youness , Maqboub Omar , Elamine Mohamed Nour-dine Elalami
Published: July 2022

BACKGROUND. Extramedullary plasmacytoma is a rare tumor, representing less than 1% of head and neck tumors. This specific type of tumor occurs in 90% of cases in the upper aero-digestive tract, with more frequent location in 80% of cases in the submucosa.

CASE REPORT. We report the case of a 39-year-old young man who presented for bilateral nasal obstruction with swelling of the left nasal region and intermittent epistaxis of moderate abundance. The clinical examination revealed a tumor mass in the nasal cavity bleeding on contact, with the absence of nasal airflow. The cranio-facial CT and MRI imaging with contrast agent showed a large, locally advanced tumor in the left nasal cavity, with destruction of the surrounding osteo-cartilaginous structures. The anatomopathological study of the biopsy specimen returned in favour of a plasmacytoma of the nasal cavity with kappa light chains. The biological assessment of the multiple myeloma confirmed that it was an extramedullary plasmacytoma. Radiotherapy treatment was proposed.

CONCLUSION. In the light of this case of extramedullary plasmacytoma, we will discuss the clinical, therapeutic and evolutionary characteristics of this tumour.
Antibacterial Activity of Clove, Oregano, Thyme, Eucalyptus, and Tea Tree Essential Oils against Escherichia coli and Klebsiella pneumoniae strains
Authors: Băicuș Anda , Mattuzzi Flavio Cesare , Paraschiv Ana Maria , Dinu Rares-Sebastian , Dumitrescu Maria Carina , Marinescu Andrei Alexandru , Ionescu Dorin , Dragos Dorin
Published: July 2022

Background: In view of the high recurrence rate of urinary tract infections and the increasing number of germs resistant to multiple antibiotics, the aim of the present study was to evaluate the antibacterial properties of clove, oregano, thyme, eucalyptus, tea tree essential oils (EOs) against 32 isolates of Escherichia coli and 28 isolates of Klebsiella pneumoniae from patients with urinary tract infections (UTI).

Methods: The agar disk diffusion method was used to assess the susceptibility of these isolates to essential oils and the minimal inhibitory concentration (MIC), and the minimal bactericidal concentration (MBC) were determined.

Results: Our results suggest that volatile phenols (such as carvacrol in oregano EO, thymol in thyme EO, and eugenol in clove EO) are more efficacious as antibacterial than non-aromatic compounds (such as eucalyptol in eucalyptus EO and terpinene derivatives in tea tree EO).

Conclusion : The oregano EO, followed by thyme appear to have the highest efficacy against Escherichia coli and Klebsiella pneumoniae isolates investigated.
Novel DCX pathogenic variant in a girl with subcortical band heterotopia
Authors: Papuc Sorina Mihaela , Budisteanu Magdalena , Erbescu Alina , Ionescu Virgil , Iliescu Catrinel , Sandu Carmen , Arghir Aurora
Published: July 2022

Subcortical band heterotopia (SBH), is a brain malformation defined by symmetrical and bilateral heterotopic gray matter bands localized deep within the white matter, between the cortex and lateral ventricles. SBH is the result of abnormal neuronal migration, with improper positioning of the cortical neurons. DCX gene (doublecortin), a microtubule-associated protein with essential roles in neuronal migration and differentiation during brain development, is one of the main contributors to the X-linked Lissencephaly spectrum pathogenesis (OMIM #300067). DCX variants are responsible for SBH in females and isolated lissencephaly in males. Herein, we present a 7-year-old girl with a de novo frameshift variant in DCX gene, unreported by date. The patient has focal complex seizures with onset at 23 months of age, fully controlled with medication, mild tremor and coordination impairment of fine movements and some learning difficulties, otherwise with normal development. The brain magnetic resonance imaging revealed the presence of thick SBH. Direct sequencing of DCX gene revealed a pathogenic heterozygous cytosine duplication in exon 3; this frameshift variant leads to a premature stop codon in position 164 (p.Gln160Profs*5). The variant type and its predicted consequence at protein level correlates with the severity of radiological findings. The clinical presentation of our patient is, however, milder than expected. Our research expands the mutational spectrum of DCX gene in SBH females and provides a detailed clinical and imagistic description of the patient. This paper highlights the utility of single gene sequencing as a first-tier diagnostic test of patients with gene-specific phenotypic features.
The severity of coronary artery defeat in coronary heart disease patients with different variants of the vitamin D receptor gene and the level of vitamin D sufficiency
Authors: Belyaeva O. D. , Du J. , Ionova Zh. I. , Karonova T. L. , Polunicheva E. V. , Miroshnikova V. V. , Dracheva K. V. , Khachikyan T. T. , Pchelina S. N. , Listopad O. V. , Berkovich O. A.
Published: July 2022

Introduction.Vitamin D deficiency may be an independent predictor of coronary heart disease (CHD) and the severity of coronary atherosclerosis. The results of studies of the association of various polymorphisms of the vitamin D receptor (VDR) gene with the risk and severity of CHD are contradictory, which necessitates the study of genetic variants of theVDRgene and the characteristics of the clinical course of CHD in the Russian population.

Theobjectivewas to determine the distribution of genotypes ofTaqI,BsmIandApaIof polymorphic variants of the VDR gene and the level of vitamin D sufficiency in CHD patients with varying severity of CHD, residents of St. Petersburg.

Methods and materials.The study included 407 CHD patients and 318 patients without clinical signs of CHD of comparable age (p>0.05). All CHD patients underwent coronary angiography. Typing of theVDRgene variants was performed by polymerase chain reaction and subsequent restriction analysis. Determination of the level of 25(OH)D blood serum was carried out by enzyme immunoassay.

Results.Vitamin D deficiency was detected in 82 % of CHD patients, the content of 25(OH)D in blood serum was lower in CHD patients who had 2 or more myocardial infarctions (MI) than in those who had one MI (p=0.03). Vitamin D deficiency is associated with a 3.6-fold increased risk of multivessel disease (p=0.01). The presence of theaagenotype and theaallele (ApaI), thebbgenotype and theballele of theVDRgene (BsmI) is associated with an increased risk of CHD and the severity of atherosclerotic lesions of the coronary arteries.

Conclusion.Vitamin D deficiency is typical for CHD patients and is associated with the severity of coronary atherosclerosis. The presence of aa genotype and a allele (ApaIpolymorphism),bbgenotype andballele of theVDRgene (BsmIpolymorphism) is associated with an increased risk of CHD and the severity of atherosclerotic lesions of the coronary arteries.TaqIpolymorphism of theVDRgene is not associated with the risk of CHD.
Anatomy of the shape of the cavity and the internal relief of the walls of the left atrial appendage
Authors: Gaponov A. A. , Iakimov A. A.
Published: July 2022

Introduction. The evaluation of the shape of the left atrial appendage into interconnection with the internal relief of its wall is of an importance for discovering anatomical patterns of the left atrium, which appears to be the most thrombogenic and are associated with a high thromboembolic risk from this chamber.

The objective was to study features of the internal relief of the walls of the left atrial appendage of the adult heart and to find the dependence of these features on the size and shape of the appendage.

Methods and material. We studied 68 left atrial silicone casts prepared from the hearts of 35–89 years men and women died from non-cardiac causes. By means a caliper, we measured the length and width of the cavity of the left atrial appendage, determined the shape, the number of lobes and intertrabecular spaces. With Image J program, we estimated the proportion of the area occupied by these spaces and pectinate muscles in pixels from photographs of the anterosuperior surface of the appendage. We used correlation analysis, Mann–Whitney U-test.

Results. We found two-lobed appendages commonly than single-lobed and three-lobed. The number of intertrabecular spaces was 4–41 (median 21), with one-lobed appendages having fewer than twoand three-lobed. The same parameter was higher in the «chicken wing» than in the «arrowhead» specimens (23 vs 18, p=0.004). The proportion of the area occupied by the pectinate muscles and intertrabecular spaces in the left atrial appendage was 47 % (16–83 %) and showed none association with the shape of the cavity and the number of lobes.

Conclusion. The number of intertrabecular spaces in the walls of the left atrial appendage correlated with its length and width and was the smallest in single-lobed specimens and in the appendages of the «arrowhead» shape. The abundant intertrabecular spaces were common for «chicken wing» variant of the left atrial appendage.
Revenue-Based Multipliers as an Indicator of the Investment Attractiveness of Domestic Vertically Integrated Oil and Gas Companies
Authors: SHIMKO Oleg V.
Published: July 2022

Subject. This article focuses on the ratios of market capitalization or enterprise value to net revenue from core activities of the twenty five leading publicly traded oil and gas companies within 2008 through 2018.
Objectives. The article aims to identify key trends in the considered ratios of the oil and gas industry corporations and in the ratio changes within the studied period, and identify the factors that have caused these changes.
Methods. For the study, I used comparative, and financial and economic analyses, and generalization of materials of the companies' consolidated financial statements.
Results. Revenue-based ratios are found to be applicable to assess the value of oil and gas companies. Companies with better profitability have higher multiplier values with a similar net revenue structure. It was determined that integrated corporations usually lag behind independent companies in terms of multiples. It was found that the output of oil products from purchased raw materials is estimated by market to be lower than products produced from own resources. The presence of resale in the revenue structure reduces the multiplier value. The debt burden growth contributes to the multiplier reduction. Therefore, in multiplier, it is advisable to use the enterprise value indicator that includes net debt instead of market capitalization with a significant difference in the debt component. The found country factor should be taken into account when using the multiplier.
Conclusions and Relevance. The use of revenue-based multipliers requires a thorough analysis of the financial and business operations of companies. However, it is quite acceptable if the overall profitability decreases and the debt burden increases in the stock market segment of the global oil and gas industry. The results of the study can be used to assess the value of oil and gas assets as part of a comparative approach and develop measures to increase the market capitalization of publicly traded oil and gas corporations.
Energy in the system of indicators of company's financial and economic activities
Authors: BURGANOV Rais A. , GOLITSYNA Lyudmila A.
Published: July 2022

Subject. The article, in a hypothetical form, offers the prospects of possible use of data on generation and utilization of various types of energy in calculating the results of company’s financial and economic activities.
Objectives. I consider the role and significance of various types of energy in the system of factors, affecting the final results of company's activities.
Methods. The study rests on methods of comparison, generalization, abstraction and hypotheses.
Results. When analyzing the financial and economic indicators of company's activities, it is necessary to take into account the process of generation and consumption of all types of energy, and not only electricity and heat. The process of implementing each of them should be in focus of theorists and practitioners, which is especially important under conditions of optimization of energy resource use and development of a nature-like economy.
Conclusions. In present-day conditions of rational use of all types of energy, searching for new reserves in the consideration of company's income and cost factors is demanded by both theorists and practitioners.
Transformation of information and analytical audit support during the digitalization of economic and accounting systems
Authors: SAFONOVA Margarita F. , KISILEVICH Tat'yana I.
Published: July 2022

Subject. This article discusses the issues of transformation of information and analytical audit support during the digitalization of economic and accounting systems. Objectives. Based on the content analysis of scientific literature and regulatory and legal sources, the article aims to form the main areas of transformation of information and analytical audit support during the digitalization of economic and accounting systems. Methods. For the study, we used induction and deduction, analysis and synthesis, and the computational, graphic, case study, and accounting and analytical methods. Results. The article finds that there are available information technologies on the market today that can help optimize a number of audit procedures and synthesize the cognitive audit ecosystem that has predictive analytics. This makes it possible to improve the quality of services provided through a continuous audit. Conclusions and Relevance. Information and communication technologies together with predictive analytics make it possible, using previously accumulated data, to transform methodological approaches to auditing and introduce consulting services with a greater scale of outreach. The results of the study can be used in the theory and practice of auditing, as well as for further scientific developments and practical application.
Transport system optimization in remote, hard-to-reach and sparsely populated regions, taking into account the requirements of environmental protection and national interests of the Russian Federation
Authors: EGOSHIN Sergei F. , KLOCHKOV Vladislav V.
Published: July 2022

Subject. The article deals with improving the structure of transportation, considering local climatic conditions.
Objectives. The focus is on investigation of the optimal structure of integrated transport system of remote, hard-to-reach and underpopulated regions of the Russian Federation by the criterion of minimum total greenhouse gas emissions, given the limitations of minimum transport standards of transportation quality.
Methods. We apply methods of statistical, systems analysis, and economic and mathematical modeling.
Results. The paper shows that in sparsely populated regions of Russia, the organization of local air traffic gives lower total carbon dioxide emissions, as contrasted with the organization of road transportation, and specifically under significant increase in the mobility of the population. The findings are valid both in terms of reducing the total greenhouse gas emissions, and in terms of reducing other emissions of harmful substances and anthropogenic impact accompanying the construction and operation of extensive ground transport infrastructure.
Conclusions. Due to the preference of air transport over ground transport, the reduction of air carriage unit cost, rather than specific emissions of harmful substances, becomes a priority for environmental protection in underpopulated regions. This conclusion is reinforced due to particular vulnerability of unique ecosystems of the Arctic zone of the Russian Federation, where transport connectivity is the most immediate concern.
Diagnostics of economic security level of Yenisei Siberia regions in the context of socio-economic sphere digitalization processes
Authors: LOBKOVA Elena V.
Published: July 2022

Subject. The article addresses treats to the economic security of Russia’s regions in conditions of large-scale introduction of information and communication technologies.
Objectives. The purpose is to explore problems of assessing the level of economic security of regional systems, analyze the impact of digitalization on systemic risks and threats to territory development.
Methods. The developed approach rests on methods of statistical data processing, the criterion of the shortest distance to the optimum, methods for constructing a fuzzy set and membership function, aggregation of indicators given the probability of occurrence of events.
Results. I obtained statistical estimates of the level of economic security and risk of the regions of Yenisei Siberia. The paper establishes the fact of rising risks and a decrease in the level of economic security of the territories, taking into account the influence of digitalization processes.
Conclusions. Processes of digital transformation entail an increase in risks and threats to economic security. This problem is particularly acute in the territories that have a smaller margin of safety in terms of parameters and indicators of socio-economic development.