bluuebunny/crossref_metadata_2025 huggingface dataset:
PERANCANGAN SISTEM VIRTUAL SHOWROOM DI WEBSITE RUPARUPA
Authors: Kasinda Felicia , Rusdi Zyad , Wasino Wasino
Published: June 2022

Teknologi digital mengubah cara kita hidup dan bekerja dengan cara yang tidak dapat kita prediksi satu generasi lalu. Seiring berkembangnya ilmu pengetahuan, perdagangan tidak hanya dilakukan secara langsung saja tetapi dibantu dengan menggunakan teknologi. Dengan adanya sistem perdagangan elektronik, transaksi jual beli tidak lagi mengharuskan pembeli dan penjual bertemu secara langsung. Sebagai perusahaan yang bergerak dalam bidang e-commerce, PT. Omni Digitama Internusa membutuhkan hal yang paling penting yaitu minat yang besar dari para konsumen agar lebih sering untuk membuka website Ruparupa. Muncul ide sebagai solusi agar pelanggan dapat mengetahui ukuran produk dan tampilan secara real di dalam ruangan dan untuk meningkatkan minat konsumen untuk membeli. Meningkatkan pengalaman konsumen dengan menghadirkan fitur Virtual Showroom yang bernama “Shop The Look” untuk melihat furniture pada ruangan berupa gambar 2D agar konsumen lebih mudah untuk mengetahui ukuran serta tampilan produk pada gambar ruangan dan membuat dashboard untuk mengelola showroom yang akan ditampilkan secara fleksibel. Sistem ini dibuat dengan menggunakan metode SDLC (System Development Life Cycle) dengan model Scrum dan menggunakan bahasa ReactJs dan MongoDB sebagai database. Fitur ini akan meningkatkan kualitas UI/UX Ruparupa yang juga akan otomatis meningkatkan penjualan dan kemudahan mengelola Virtual Showroom dengan dashboard yang user friendly
Nanoteknoloji Temelli Antimikrobiyal Yüzey Kaplama Teknolojileri ve Potansiyel Uygulama Alanları
Authors: Gökmen Gökhan Gurur , Kışla Duygu
Published: June 2022

Nanotechnology has a wide study field including organic and/or inorganic particles smaller than 100 nanometers and all kinds of technological studies developed using these particles. In the production of nanoparticles, top-down approaches in which macro-sized materials were reduced to nano-sizes and bottom-up approaches in which atoms / molecules were increased to nano-sizes by different chemical reactions, are used. Currently, nanoparticles produced by top-down approaches might be used in many industries such as food industry, water treatment systems, cosmetics, and medicine. Microorganisms that tend to move, adhere, and colonize a solid surface, cause the formation of microbial biofilm on these surfaces. Microbial biofilms show high resistance to traditional antimicrobial applications in industrial environments especially where food is processed, water piping systems, biological tissues and medical implants. Therefore, the requirement has emerged to make not only the surfaces in direct contact with people, but also the surfaces in contact with food, to be resistant to microorganisms by different antimicrobial coating techniques. In this review, it is aimed to give information about the production methods of nanomaterials, different antimicrobial surface-coating techniques, the mechanism of antimicrobial nanoparticles on microorganisms and potential applications of antimicrobial surfaces.
Monokromatik LED Aydınlatmanın Etlik Piliçlerin Performansı, Göğüs Eti Kalitesi, Tibia Kemiği Özellikleri ve İmmunoglobulin G Düzeyine Etkisi
Authors: Bingöl Tolga , Akşit Mustafa
Published: June 2022

This study is conducted to improve growth performance, breast meat characteristics, welfare, and immunity level of broiler chickens by using a combination of monochromatic LED light in the early and later periods of the rearing. A total of 576 one-day old mixed sexes broiler chickens (ROSS 308) were randomly assigned to one of 4 treatments: 1) White fluorescent light (Control, WF), 2) Green LED light (G), 3) Blue LED light (B) and 4) Green-Blue LED combination light (G-B) (green light for first 3 weeks, switching to blue light for remaining 3 weeks). Body weights (BW), body weights gain (BWG), feed intake (FI), feed conversion ratio (FCR) and mortality rates were determined. In addition, on d 39, gait score and at 21 and 40 d of age, tonic immobility (TI) duration and at 28 and 40 d for immunoglobulin G (IgG) in serum and at d 42 of age, pectoral muscle quality and tibia bone characteristics were determined. The results showed that birds under Y-M had significantly higher CA in the first 21 days than these of BF and M and in the last 3 weeks than the broilers in the BF and G. At the end of the experiment, it was revealed that the B and G-B groups consumed more feed than the other groups. FCR, mortality rates and TI duration in broilers were not affected by light treatments. Light affected the gait score which is a welfare indicator in broilers was affected and G group had the worst gait score. Light affected values of pH24, b* and water-holding capacity in the breast muscle and the lowest pH24 value appeared in G-B group. On 40th day of the trial, although the IgG levels in all the treatment groups decreased according to the 28th day, the IgG level of G-B group was found higher than the other groups. In conclusion, the present study shows that in chickens, the monochromatic G-B combination had a positive effect on the growing and especially the high level of IgG determined in the blood serum showed that it can be effective in development of a strong immunity.
Büyüyen Japon Bıldırcınlarında Rasyona Bacillus subtilis İlavesinin Büyüme Performansı, Organ Ağırlıkları ve Bazı Serum Parametrelerine Etkileri
Authors: Cufadar Yusuf , Curabay Barışcan , Doğan Rukiye
Published: June 2022

This study was carried out to determine the effects of Bacillus subtilis addition to growing Japanese quail diets on growth performance, some serum parameters and carcass parameters. In the study, a total of 200 mixed-sex Japanese quail (Coturnix coturnix japonica) chicks were fed for 35 days with diets formed with the addition of different levels of control and Bacillus subtilis (250, 500, 750 mg/kg). The study was carried out in 4 treatment groups with 5 replications. At the end of the experiment, Bacillus subtilis levels did not affect the feed intake and feed conversation ratio, which are performance parameters, but affected the body weight and body weight gain statistically significantly. The addition of Bacillus subtilis to the diets of growing Japanese quails showed that glucose and creatinine concentrations were significantly affected, and urea, triglyceride, cholesterol, total protein, phosphorus and calcium values were not affected by the treatment levels. Among the carcass parameters, carcass yield, liver weight, pancreas weight, heart weight, gizzard weight and intestinal length did not statistically differ between the treatment groups. According to the results of the present study, it can be said that the addition of Bacillus subtilis at the level of 500 mg/kg to growing quail diets may be beneficial in terms of improving performance.
COVID-19 Pandemic and Changes to Finland’s Legislation in Line with the WHO Guidelines
Authors: Jilkine Vladimir
Published: June 2022

The article analyses new legislative amendments in Finland, including an interim amendment to the Infectious Diseases Act, which aims to protect the life and health of clients and patients using social and medical services. The rapid spread of the number of cases of coronavirus infection in Finland, including the new Omicron strain, required urgent measures and new amendments to the legislation. Therefore, in the context of the overall fight against the coronavirus pandemic in the world, these provisions of the Finnish Constitution are a transition from the absolute priority of universally recognised norms of international law to the priority of the Basic Law, subject to the condition of the inadmissibility of guaranteed restriction of human rights. Finland’s desire to comply with the global integration processes in the context of persisting risks of the spread of coronavirus infection has led to digital harmonisation of legislation and legal norms in accordance with the principles of international law. The amendments to Finnish legislation were based on the enshrined provisions of the Constitution and the existing international legal framework, considering possibilities for responding to pandemic and transboundary emergencies in accordance with WHO guidelines.
Directions for Improving Legal Support of Vocational Training of Forensic Experts in Ukraine
Authors: Kurdes Oleg
Published: June 2022

Current Regulations on Central Expert Qualification Commission under the Ministry of Justice of Ukraine and certification of forensic experts establishing the procedure for conducting professional training of forensic experts have been analysed. Necessity of elaboration and adoption of a separate legal regulation that should regulate all components of professional training procedure of forensic experts has been proved. Directions of development of professional training system of forensic experts have been indicated: traditional system of training that consists of two parts: professional training in higher education and postgraduate education majoring in Forensic Science. A new type of structure of postgraduate education of forensic experts has been proposed that should consist of initial professional training, advanced training, retraining and specialised training. In order to adapt to new working conditions and accelerate professional training of experts, the need to introduce the institute of mentoring has been emphasised. Given the specifics of forensic science activities associated with psychological stress while forensic research, emphasis has been placed on psychological training introduction. The ways of reforming structure of subjects of administrative and legal support of professional training of forensic experts have been indicated.
Puerto Rico Recurrence Scale: Predicting chronic subdural hematoma recurrence risk after initial surgical drainage
Authors: Mignucci-Jiménez Giancarlo , Matos-Cruz Alejandro J. , Abramov Irakliy , Hanalioglu Sahin , Kovacs Melissa S. , Preul Mark C. , Feliciano-Valls Caleb E.
Published: June 2022

Background:

Chronic subdural hematoma (CSDH) commonly affects older individuals and is associated with a relatively high rate of recurrence after surgery. Many studies have created grading systems to identify patients at high risk of CSDH recurrence after the initial surgery. However, no system has been adopted widely. The authors present the first CSDH grading system created from a population-based single-center data set.

Methods:

A single-center Puerto Rican population-based retrospective analysis was performed on consecutive patients treated for a CSDH at a designated institution from July 1, 2017 to December 31, 2019. Univariate and multivariate analyses were used to create a CSDH recurrence grading scale. Retrospective validation was conducted on this sample population.

Results:

The study included 428 patients. Preoperative midline shift, postoperative midline shift, and size of postoperative subdural space differed between the recurrence and nonrecurrence groups (P = 0.03, 0.002, and 0.002, respectively). A multivariate analysis was used to create a 10-point grading scale comprising four independent variables. Recurrence rates progressively increased from the low-risk (0–3 points) to high-risk (8–10 points) groups (2.9% vs. 20.3%; P < 0.001).

Conclusion:

A 10-point grading scale for CSDH recurrence was developed with four components: preoperative midline shift (≤1 and >1 cm), laterality (bilateral, unilateral-right, and unilateral-left), size of postoperative subdural space (≤1.6 and >1.6 cm), and pneumocephalus (present or absent). Patients who scored higher on the scale had a higher risk of recurrence. This CSDH grading scale has implications for Puerto Rico and the general population as the elderly population increases worldwide.
Hemifacial spasm due to vertebral artery dissecting aneurysm treated with stent-in-stent placement; Pre- and post-treatment evaluation by 3D multifusion imaging using silent MR angiography
Authors: Satoh Toru , Sato Yu , Sugiu Kenji , Hishikawa Tomohito , Hiramatsu Masafumi , Haruma Jun , Date Isao
Published: June 2022

Background:

Hemifacial spasm (HFS) due to vertebral artery (VA) dissecting aneurysm (VADA) is rare and endovascular treatment has been performed in selected cases.

Case Description:

We encountered a case of HFS caused by VADA that was managed with endovascular stent placement and additional stent-in-stent placement. Therapeutic strategies and benefits based on pre- and post-treatment evaluation by 3D multifusion imaging using silent MRA were discussed.

Conclusion:

This is the first case report of stent-in-stent placement in successful treatment of HFS caused by VADA, in which relief of neurovascular contact was demonstrated by multifusion imaging.
Terminal myelocystocele: Surgical management
Authors: Massa Daniela Sol , Montivero Nicolas Arturo , Medina Santiago Adalberto Portillo
Published: June 2022

Background:

The authors describe clinical and imaging findings, surgical technique, and outcomes in myelocystocele.

Methods:

We describe a surgical procedure performed in six patients, four males and two females, with myelocystocele treated at our hospital. We review the images obtained at the time of diagnosis and after surgery. The patients’ age range was 12–56 months and had undergone surgery for terminal myelocystocele between 2015 and 2020. All patients had a large lumbar mass covered with healthy skin and presented spontaneous movements at birth. Two patients presented VACTERL syndrome.

Results:

A watertight closure of the soft tissues was performed in all cases. None of the patients presented postsurgical complications, such as cerebrospinal fluid leak or infection. All the patients had undergone excision of the meningocele sacs, the tethering bands were lysed, and the filum was detethered. The mean follow-up period was 34 (12–56) months. A motor deficit was seen in 2 patients (33.3%).

Conclusion:

Prenatal diagnosis and early corrective surgical intervention are recommended to prevent deterioration in neurological function. VACTERL association is a common condition and should be investigated.
Microbial biomass production using sugarcane industrial by-products and their application to Nile tilapia aquaculture
Authors: Ali Sayeda M. , Aboseif Ahmed M. , El-Gamal Ahmed D. , El-hammady Ahmad K.
Published: June 2022

The sugarcane industrial wastewater is considered as one of the main sources of River Nile pollution. Here we study the possibility of using sugarcane wastewater effluent amended with molasses and clay factory as a culture medium for growth and biomass production of Chlamydomonas reinhardtii and Azotobacter chroococcum and the possibility of using this biomass for Oreochromis niloticus aquaculture. Results of this study indicated that some physico-chemical analyses of waste water are non-compliant with Law 48/1982 such as decreasing values of dissolved oxygen (0.77 mg/1), increasing temperature (40-50°C) and increasing values of chemical oxygen demand (31.5 mgO2/l). These pollutants were dealt for growth and biomass production of Azotobacter chroococcum and Chlamydomonas reinhardtii after amendment with molasses and industrial clay (press mud). Results showed that the wastewater amended with 1% press mud, 1% molasses and 0.5g/l CaCO3 was the best for A. chroococcum. In addition, high growth of Chlamydomonas was obtained in the sugarcane wastewater amended with 1% molasses with 0.5% press mud. Moreover, addition of Azotobacter had positive effect on growth of Chlamydomonas especially when added after 24 hours of Chlamydomonas growth. Biomass of both C. reinhardtii and A. chroococcum (which was grown on sugar can industrial by-products) has high potential for Oreochromis niloticus aquaculture, where highest weight gain and specific growth rate of fish were recorded. Further research work is needed to confirm the safety and viability of this microbial biomass produced from industrial sugar cane by-products in Nile tilapia aquaculture.
Association of polymorphisms in four low-penetrance genes (ACYP2, CCNE1, ERCC5 and lincRNA CASC22) with breast cancer risk in a Vietnamese population
Authors: Thanh Thi Ngoc Nguyen , Luan Huu Huynh , Hoang Ngo Phan , Hue Thi Nguyen
Published: June 2022

In breast cancer (BC), four low-penetrance genes (ACYP2, CCNE1, ERCC5 and lincRNA CASC22) are involved in cell cycle arrest, DNA damage repair and long non-coding RNA-mediated regulation is commonly known as causative genes of tumorigenesis. A functional polymorphism in these genes may cause cancer by altering the genes' structure and function. Single Nucleotide Polymorphisms (SNPs) have been discovered to be capable of predicting cancer risk, hence can be used as carcinogenesis markers. To date, the correlation of four SNPs (rs12621038, rs3218038, rs751402 and rs12325489) with BC risk in different populations has been revealed by numerous researches. This study examines the association between these SNPs and the risk of developing BC in Vietnamese women. These four SNPs were genotyped by HRM assay. The differences in allelic and genotypic frequencies between cases and controls were analyzed to determine their relationship with BC risk. While rs12621038, rs3218038 and rs751402 showed no relation to BC, there was an association between rs12325489 and BC risk. In both codominant and overdominant models, the lincRNA CASC22 rs12325489 was consistently associated with BC risk (TT vs. CC: OR = 0.63, 95% CI = 0.44 to 0.90, P = 0.01 and TC vs. TT + CC: OR = 0.61, 95% CI = 0.43 to 0.84, P = 0.003; respectively). These results indicated that rs12325489 could be a potential biomarker for predicting BC risk in Vietnamese women.
Assessment of fermentation processing effect on phenolic, flavonoids contents and antioxidant activity of commonly used pulses
Authors: Sadh P.K. , Saharan P. , Duhan S. , Suneja P. , Duhan J.S.
Published: June 2022

Pulses are rich sources of natural antioxidants but are mostly present as bounded phytochemicals. So, in the present study, polyphenolic and antioxidant activities of five commonly used pulses such as red lentil, cowpea, pigeon pea, urad and mung bean were studied through fermentation using GRAS fungal strain Aspergillus oryzae. Results showed a significant (P < 0.05) enhancement of phenolic as well as antioxidant activity in all fermented pulses as compared to the nonfermented one. The maximum increase of polyphenols and antioxidants after fermentation was observed in pigeon pea followed by urad, red lentil, mung bean and cowpea. A linear correlation obtained between α-amylase, xylanase and β-glucosidase enzymes polyphenols and antioxidants justified their role in the release of bound phenolic. Similarly, a positive correlation was attained between the total phenolic as well as antioxidant activity of the samples.
Targeting the key players of DNA Repair Pathways as Cancer Therapeutics
Authors: Roy R. , Garimella S.V. , Pandrangi S.L.
Published: June 2022

The DNA Damage Response (DDR) is essentially a complicated network of cellular pathways involving a vast array of signalling proteins that help in maintaining the genome integrity of the cell and its turmoil is one of the hallmarks of cancer. Longestablished treatment of cancer with radiation therapies or genotoxic chemotherapies has exploited the defects in the DNA damage response for therapeutic application. The recent strategies for targeted therapy aim on inhibiting the DNA damage response in cancer which offers a greater potential by tailoring treatment to patients with tumours lacking specific DDR functions. This out-manoeuvres one of the key limitations of many DNA-damaging therapies, which is their inability in selectively targeting cancer cells that in turn leads to toxic effects on healthy cells and disastrous effects for patients. This review highlights the different concepts of DNA damage and repair mechanisms that exist in a living cell. In addition, it discusses the small molecule inhibitors of DDR pathway that seem to be promising cancer therapeutics.
Determination of deleterious single nucleotide polymorphisms of human lactoferrin gene
Authors: Venkata Subbiah Harini , Ramesh Babu Polani , Subbiah Usha
Published: June 2022

Lactoferrin (LTF) is an important constituent of innate immune system and an antimicrobial peptide (AMP) possessing both antimicrobial and immunomodulatory properties. In this study, missense nonsynonymous single nucleotide polymorphisms (nsSNPs) of LTF gene were systematically collected and analyzed for their deleterious nature using various computational methods. Different in silico tools were used to analyze nsSNPs of LTF gene. The nsSNPs were first subjected to SIFT and Polyphen v2 tools. These nsSNPs were further analyzed by other online tools – PROVEAN, SNAP, PhD-SNP and SNPs&GO to increase the likelihood of effective prediction. I-Mutant 3.0 was employed to predict the consequence of variants on LTF protein’s stability. Gene and protein interactions of LTF protein were studied by GeneMANIA and STRING tools respectively. FT site server was used to infer the ligand binding sites of LTF protein. Also, the nsSNPs of LTF gene were subjected to PROJECT HOPE analysis. SIFT and Polyphen v2 tools observed 32 SNPs to be deleterious and probably damaging respectively. Gene and protein interaction networks predicted that LTF protein interacted with lysozyme and neutrophil gelatinase associated lipocalin (LCN2). PROJECT HOPE analysis predicted that G422C, G130C, P614L, P614S, T666I, E34K, C424R, G493D, L430Q, C250R, R360W, G528D and W366C were damaging to LTF protein. LTF gene nsSNPs were predicted for their deleterious nature by using various in silico tools which could form the baseline for further analyzing them using experimental work and could be potentially used for precision medicine.
Network based identification of Potential Key Genes associated with Alzheimer’s disease and Type 2 Diabetes using mTOR signalling
Authors: Buddham R. , Yadav S. , Narad P. , Gupta D. , Mathur P.
Published: June 2022

mTOR is involved in various signalling pathways, including TSC1/TSC2/Rheb, PI3K/Akt, LKBL/AMPK, VAM6/Rag GTPase etc. and dysregulation of the mTOR pathway has been related with cancer, neurological diseases and type 2 diabetes. In the present work, we created a comprehensive network of mTOR signalling that consisted of 255 nodes (proteins/genes) and 592 edges (interactions) using the Cytoscape 3.6 editor and its plugins for analysis. The experimental design included retrieving gene expression profiles for two diseases, namely Alzheimer's disease (AD) and type 2 diabetes (T2D), from the Gene Expression Omnibus (NCBI GEO) and performing pre-processing and normalisation using R and Bioconductor. The ExprEssence plugin was used to identify differentially expressed genes (DEGs) across gene expression samples using network condensation. GO (Gene Ontology) analysis was performed using PANTHER along with Venn plot for identification of overlapping proteins/genes between two microarray datasets of AD and T2D. PDK1 (3-Phosphoinositidedependent kinase 1) was identified as a common upregulated DEG between both the disease conditions (AD and T2D). The Schrödinger TM Suite was employed for ligand and protein preparation, docking investigations and pharmacophore development. Based on docking score, phase screen score and site of interaction, two compounds namely (2R,3R,4S,5S,6R)‐ 4,5‐dihydroxy‐2‐methyl‐6‐{[(2S,3R,4R,5S,6R)‐3,4,5‐tr ihydroxy‐6‐{[5 ‐hydroxy‐6‐methoxy‐2‐(4‐methoxyp henyl)‐4‐oxo‐4H‐chromen‐7‐yl]oxy}oxan‐2‐yl]methox y}oxan‐3‐yl aceta te and 5‐hydroxy‐6‐methoxy‐2‐(4‐ methoxyphenyl)‐7‐{[(2R,3S,4R,5R,6S)‐ 3,4,5‐trihydrox y‐6‐({[(2R,3S,4R, 5R,6R)‐3,4,5‐trihydroxy‐6‐methylox an‐2‐yl]oxy} methyl)oxan‐2‐yl]oxy}‐4H‐chromen‐4‐ one) were identified as potential inhibitors of PDK1.
The impact of bacterial prostatitis and IL-17 in male infertility
Authors: Alhadrawi Kais Khudhair , Darweesh Mayyada F. , Aldhalmi Hanan Khaled
Published: June 2022

A case-control study aimed to assess the role of IL-17 serum level and bacterial prostatitis in development of male infertility. 120 patients from January to June 2021 included 60 prostatitis infertile patients, 30 prostatitis patients and 30 infertile patients as well as 30 healthy fertile male subjects. Blood and semen sample were collected from all subjects. 3 ml of venous blood was put in gel tube to separate serum estimate the IL-17 level by ELISA. A loop full of semen was taken to isolate bacterial causes and the remaining semen was analyzed to detect semen liquefaction, volume, appearance and basic sperm parameters (density, motility, viability and morphology). The results showed a significant increase (P<0.05) in serum concentration of IL-17 in prostatitis infertile patients than prostatitis compared to infertile patients. According to a grade of the infertile male, the concentration of IL-17 increased with severity of disease and this is considered as a biomarker for progression. The results revealed that E.coli followed by S.aureus is the most common bacterial cause of prostatitis infection. The current study concluded that the infection with prostatitis disease affects the body's immune response represented by increased level of IL- 17 and correlated with infertility.
ZmbHLH121, a maize bHLH transcription factor inducing leaf senescence by accelerating ROS accumulation in maize (Zea mays L.)
Authors: Das Anuj Kumer , Hao Liu , Khan Siffat Ullah , Jun Zhao
Published: June 2022

Leaf senescence is the final stage of leaf development which is induced by many genetic and environmental factors. To reveal the role of transcription factors in leaf senescence, we studied the function of a bHLH transcription factor ZmbHLH121 in maize. The overexpression of ZmbHLH121 exhibited phenotypes with leaf senescence. Higher expression pattern of ZmbHLH121 was observed in the immature leaves through expression analysis at early vegetative developmental stages. Results of 3,3-diaminobenzidine (DAB), nitroblue tetrazolium chloride (NBT) histochemical analysis, quantitative measurement of reactive oxygen species (ROS), chlorophyll quantification and transcriptome analysis revealed that, ZmbHLH121 positively regulated leaf senescence by accelerating ROS production and chlorophyll breakdown in maize leaves. It is suggested that, ZmbHLH121 regulated leaf senescence might be due to the excess amount of ROS production and chlorophyll loss in leaves. This study provided useful clue about the mechanism of ZmbHLH121 mediated leaf senescence.
In vitro evaluation of modified pericardium for cardiovascular applications
Authors: Le Tuyet Thi Vi , Tran Ha Le Bao , Nguyen My Thi Ngoc
Published: June 2022

The growing prevalence of cardiovascular diseases is leading to an increase in required cardiovascular implants. Pericardial tissues have been used for bioprosthetic manufacture due to advantage in availability and excellent mechanical properties. Porcine pericardium is considered to be suitable for prosthetic fabrication. In this study, porcine pericardium was decellularized and cross linked with 0.05% glutaraldehyde. The modified pericardium was characterized by histology staining, FTIR, mechanical properties and suture retention. In vitro degradation of the modified pericardium was determined via the remaining dry weight and hydroxyproline assay after incubation in collagenase solution. The modified membrane was evaluated for in vitro cytotoxicity and supporting human endothelial progenitor cell attachment and proliferation. Trichrome staining and FTIR examination revealed the crosslinking effect of glutaraldehyde with more tight internal collagen fibers structure and slight shift of amide II group. In comparison to the decellularized sample, the modified membrane showed a strong mechanical and suture retention strength. Significant resistance to enzymatic digestion was also recorded. The modified pericardium did not cause toxicity to the fibroblast and supported an appropriate adhesion and proliferation of human endothelial progenitor cells. These results indicated that the modified pericardium could be utilized as a potential natural scaffold for cardiovascular applications.
Digital technologies in the system of teaching students at the university
Authors: Imaeva E. Z. , Sukhareva N. A. , Kostikova Yu. V.
Published: June 2022

The study aims at identifying the role of the digital technologies in the system of teaching students at the university. The following methods were used in the study: testing, questioning, analysis of performance results, mathematical methods of data processing, etc. Methods for diagnosing learning motivation and emotional attitude to learning, studying the levels of formation of students’ cognitive interests (author’s method), a questionnaire for assessing students’ knowledge in the field of research activities were applied as well. The data of the students’ final progress in subjects were also analysed. An analysis of the main results of the study allows us to conclude: students who were asked to use digital technologies in teaching showed significant differences before and after the experiment on all scales of the study (the learning motivation level, the cognitive interest level, the knowledge level in the research activities field, assessment of the final performance in subjects). The analysis of the results also showed that according to all the data obtained at the stage of the control experiment, the reliability of the differences in the conclusions of the experimental and control groups on all scales of the study is confirmed.
High Energy Density Picoliter Zn-Air Batteries for Colloidal Robots and State Machines
Authors: Zhang Ge , Yang Jingfan , Gonzalez-Medrano David , Miskin Marc Z. , Koman Volodymyr B. , Zeng Yuwen , Li Sylvia Xin , Kuehne Matthias , Liu Albert Tianxiang , Yang Sungyun , Brooks Allan M. , Strano Michael S.
Published: June 2022

The recent interest in microscopic autonomous systems, including microrobots, colloidal state machines and smart dust has created a need for microscale energy storage and harvesting. However, macroscopic materials for energy storage have noted incompatibilities with micro-fabrication techniques, creating significant challenges to realizing microscale energy systems. Herein, we photolithographically pattern a microscale Zn/Pt/SU-8 system to generate the highest energy density microbattery at the picoliter (10^-12 L) scale. The device scavenges ambient or solution dissolved oxygen for a Zn oxidation reaction, achieving an energy density ranging from 760 to 1070 Wh L-1 at scales below 100 μm lateral and 2 μm thickness in size. More than 10,000 devices per wafer can be released into solution as functional colloids with energy stored onboard. Within a volume of only 2 pL each, these microbatteries can deliver open circuit voltages of 1.16 V with total energies ranging from 5.5 ± 0.3 to 7.7 ± 1.0 μJ and a maximum power near 2.7 nW. We demonstrate that such systems can reliably power a micron-sized memristor circuit, providing access to non-volatile memory. We also cycle power to drive the reversible bending of microscale bimorph actuators at 0.05 Hz for mechanical functions of colloidal robots. Additional capabilities such as powering two distinct nanosensor types and a clock circuit are also demonstrated. The high energy density, low volume and simple configuration promise the mass fabrication and adoption of such picoliter Zn-air batteries for micron-scale, colloidal robotics with autonomous functions.
A Direct Access to Thiocyano-Thioesters from Cyclic Thioacetals via Photoredox Catalysis: An Introduction of Two Functional groups in One-Pot
Authors: Bhat Dr Ramakrishna G. , Dharpure Pankaj D , Behera Mousumi , Khade Vikas V , Thube Archana S
Published: June 2022

The cyanation of organic compounds is an important and useful process as it directly provides nitriles which in turn can be utilized for different transformations. Although, thiocyanate salt has emerged as a very mild and environmentally friendly “source of CN” alternative to toxic and metal based cyanating reagents; its synthetic utility for the cyanation is highly limited to very few types of organic compounds. We have explored the reactivity of sodium thiocyanate for directly cyanating cyclic thioacetals for accessing thiocayano-thioesters with two different functional groups in one pot using photoredox catalysis under mild reaction conditions. Based on the reactivity of thiocyanate radical, the protocol has been further extended for the direct cyanation of disulfides and diselenides to access aryl thiocyanates and aryl selenocyanate. A series of control experiments and Stern-Volmer studies have been carried out to validate the mechanistic pathways.
New Synthetic Route to Water Soluble Prism[5]arene Hosts and their Molecular Recognition Properties
Authors: Zhai Canjia , Isaacs Lyle
Published: June 2022

We report that the direct macrocyclization of naphthalene monomers (N1 and N3) bearing ethyl ester functional groups delivers prism[5]arene derivatives (H1E and H3E) which can be deprotected to yield water soluble prism[5]arenes (H1 and H3). 1H NMR spectroscopy showed that dicationic guests G1 – G9 bind with the hydrophobic cores buried inside the anisotropic magnetically shielding cavity. Isothermal titration calorimetry measurements showed that H1 and H3 are high affinity hosts in PBS buffered water with Ka values exceeding 109 M-1 for G9. The complexation events are driven by the non-classical hydrophobic effect, CH•••p interactions, and electrostatic interactions. Host H1 displays somewhat higher affinity toward a common guest than WP6 but is significantly less potent than P6AS. Nevertheless, H1 and H3 should be considered alongside other high affinity hosts for a variety of chemical and biological applications.
Pengaruh Penatausahaan Aset dan Pemanfaatan Teknologi Informasi Terhadap Ketepatan Waktu Pelaporan Keuangan: Studi Kabupaten Barito Utara
Authors: Damanik Eko Bastian , Hayat Atma , Sayudi Akhmad
Published: June 2022

This study aims to determine the effect of human resource competence, leadership commitment, administration of fixed assets and the use of information technology on the timeliness of SOPD financial report submission. Respondents used in this study are SOPD leaders and employees who work in financial management. Data were collected by distributing questionnaires to 112 people, but only 90 questionnaires were returned and could be processed. The sampling technique uses the pusposive sampling method. Data analysis using logistic regression with SPSS version 23. The results of this study indicate that the variable administration of fixed assets and the use of information technology affect the timeliness of SOPD financial statements submission while the variables of human resource competency and leadership commitment do not affect the timeliness of SOPD financial report submission.
Pengaruh Kinerja Lingkungan, Kepemilikan Manajerial TerHadap Pengungkapan Corporate Social responsibility
Authors: Kholifah Siti
Published: June 2022

This study aims to analyze the effect of the audit committee, environmental performance, profitability, and managerial ownership on the disclosure of corporate social responsibility in manufacturing companies in Indonesia. The research approach used is descriptive verification analysis using secondary data. The population in this study are manufacturing companies listed on the Indonesia Stock Exchange in 2015–2019. The sampling technique used is non-probability sampling using purposive sampling method. Statistical analysis used in this study is multiple linear regression. The results of this study indicate that the audit committee, environmental performance, and profitability have a positive effect on the disclosure of corporate social responsibility. Meanwhile, managerial ownership has a negative effect on the disclosure of corporate social responsibility.
Pengaruh Efektifitas Pengendalian Internal dan Pengembangan Mutu karyawan terhadap Deteksi Kecurangan (Fraud)
Authors: Nyoto Susanto Deni Raharjo , Nafi Moch
Published: June 2022

The research aimed at analyzing internal effectiveness and developing analysis of fraud detection. The technique used was multiple linear regression analysis with the stages of descriptive statistical tests and data analysis. To analyze the data consisted of validity test, reliability test, normality test, multicollinearity test, heteroscedasticity test, variable t hypothesis, determination test, and hypothesis test f. The results showed that partially and simultaneously each was independent, namely the effectiveness of internal control and development. quality has a significant and positive effect on the fraud examination variable.
Penerapan Akuntasi Berdasarkan SAK ETAP pada DIY (Do It Yourself) UMKM di Kabupaten Lumajang
Authors: Arifiyanto Rizal Tri , Apriyanto Gaguk , Sumtaky Maxion
Published: June 2022

This study aims to analyze the application of accounting in DIY (Do It Yourself) MSME in Lumajang Regency and analyze the suitability of accounting application in the DIY (Do It Yourself) MSME in Lumajang Regency with SAK-ETAP. Researchers used qualitative descriptive research methods. The sample in this study was 10 respondents, the sampling technique used was the census. The analysis technique is through data collection, data reduction, data presentation and conclusion drawing. The application of accounting DIY (Do It Yourself) MSME in Lumajang Regency is still very simple, most of them only record income and expenses and are recorded manually. The application of accounting in DIY (Do It Yourself) MSME in Lumajang Regency has not yet been in accordance with Financial Accounting Standards Without Public Accountability, because there are several stages that have not fulfilled the accounting cycle. This is due to a lack of technical knowledge in the preparation of financial reports, especially based on SAK-ETAP and a lack of awareness from the DIY (Do It Yourself) in Lumajang Regency about the importance of complete and standardized financial reports. The DIY MSME in Lumajang Regency feels that the financial statements that show the company's profit and loss are sufficient.
Analisis Kinerja Keuangan Perusahaan Penerbangan pada Masa Pandemi Covid-19
Authors: Kurniawati Ratna , Listyowati Listyowati
Published: June 2022

This study aims to determine the impact of the COVID-19 pandemic on the financial performance of airlines as seen based on the ratio of liquidity, solvency, activity, and profitability. The subjects in this study were airlines listed on the IDX, which consisted of 3 companies, namely PT Garuda Indonesia (Persero) Tbk, PT Air Asia Indonesia Tbk, and PT Indonesia Transport Infrastructure Tbk. The data collection technique in this research is data documentation which comes from www.idx.co.id. The results of this study indicate that the COVID-19 pandemic has a negative impact on the financial performance of airlines. The decline in financial performance was marked by a decrease in the calculation results of the liquidity ratio, activity and profitability as well as an increase in the calculation results of the solvency ratio. Of the three airlines listed on the IDX, PT Air Asia Indonesia Tbk is the airline that experienced the greatest impact due to the COVID-19 pandemic, this is because prior to the COVID-19 pandemic, PT Air Asia Indonesia Tbk's business activities were mostly on outside travel. country, but at the time of the COVID-19 pandemic, many countries closed their access to foreign flights. While PT Indonesia Transport Infrastructure Tbk is an airline company whose financial performance has only experienced the least impact of the COVID-19 pandemic when compared to PT Air Asia Indonesia Tbk and PT Garuda Indonesia (Persero) Tbk because most of these business activities in this company are the transportation of goods such as oil and gas.
Dampak Corporate Governance, ROA Dan Leverage terhadap Penerapan Tax Avoidance
Authors: Dilasari Ike , Sitinjak Norman Duma , Kusumowati Dewi
Published: June 2022

Companies need to make efficiency so that the profits obtained can be optimal. tax is one of the objects of company efficiency. tax avoidance is a way for companies to safely minimize the tax burden. safe because it does not violate tax rules. corporate governance, roa and leverage are variables that can affect tax avoidance activities. this study examines the impact of corporate governance, roa and leverage on the implementation of tax avoidance. the method used is quantitative. the companies studied are companies registered as CGPI participants. the analysis technique uses multiple regression analysis. the test results show that the three independent variables affect the implementation of tax avoidance. changes in corporate governance activities, roa value and leverage can result in changes in tax avoidance activities carried out by the company. CGPI participating companies need to focus more on corporate governance, roa and leverage in carrying out tax avoidance activities.
Technopreneurial intention: peran self-efficacy, entrepreneurship education, dan relation support
Authors: Alamsyahrir Dendy , Ie Mei
Published: June 2022

Technopreneurship merupakan tren di masa waktu yang akan datang, tepatnya dimulai pada era revolusi industri 4.0. Technopreneurship merupakan konsep penggabungan antara kewirausahaan dan teknologi, diikuti dengan kreativitas dan inovasi yang dilakukan. Jumlah wirausahawan berbasis teknologi di Indonesia saat ini hanya sekitar 0,43% dari jumlah wirausahawan di Indonesia, sedangkan peluang technopreneurship masih sangat besar dan berpotensi. Penelitian ini bertujuan untuk menguji secara empiris pengaruh variabel self-efficacy terhadap technopreneurial intention, pengaruh variabel entrepreneurship education terhadap technopreneurial intention, serta pengaruh variabel relation support terhadap technopreneurial intention pada mahasiswa Universitas XYZ. Penelitian ini menggunakan 125 sampel mahasiswa yang dipilih melalui non-probability sampling dengan teknik purposive sampling. Analisis data pada penelitian ini merupakan kuantitatif dengan menggunakan Structural Equation Model (SEM), yang diproses dengan bantuan software SmartPLS 3.2.8. Hasil penelitian menunjukkan bahwa self-efficacy berpengaruh positif dan signifikan terhadap technopreneurial intention; entrepreneurship education berpengaruh positif dan signifikan terhadap technopreneurial intention; dan relation support berpengaruh positif dan signifikan terhadap technopreneurial intention.

Kata kunci: dukungan relasi; efikasi diri; intensi teknopreneurial; pendidikan kewirausahaan.
The testing of common risk factors toward portfolio’s excess return
Authors: Tanzil Ivan Chandra , Wijaya Liliana Inggrit , Marciano Deddy
Published: June 2022

This study aims to examine common risk factors' effects in the Fama and French Five-Factor Model plus Momentum Factor on The Bisnis-27 Index Stocks component during the 2016-2020 period. This research's common risk factors include market risk premium, firm size, book-to-market equity ratio, profitability, investment, and momentum. A quantitative approach will be used in this study by using multiple linear regression. The regression in this study was generated by the common effects model method. This study reveals that a portfolio's excess return is simultaneously affected by common risk factors that are in place this study. The findings in this study show that market risk premium, book-to-market ratio, company size, and momentum positively affect portfolios' excess returns. The greater the market risk premium, the smaller the size of the company, the larger the book-to-market ratio, and the stock's past performance, as reflected by the momentum, has implications for the acquisition of a larger excess return on the portfolio. Meanwhile, there is no significant influence between profitability and investment factor on portfolios' excess returns.
Synthesis and Characterization of New Coumarin Derivatives
Authors: Ahmed Amer Mahmoud
Published: June 2022

New Schiff base compounds 3-acetyl-2-oxo-2H-chromen-7-yl-4(alkyloxy) benzoate thiosem icarbazide have been synthesized from the reaction between thiosemicarbazide and substituted coumarin. Target compound were characterized by FT-IR and NMR techniques heterogeneous coumarin compound. The result confirms the structure as suggested
The Charge and Spin Thermoelectric Properties across Double Quantum Dots Serially Coupled to Ferromagnetic Leads: The Case of Parallel Magnetic Configuration
Authors: Najdi M. A.
Published: June 2022

In this article, the charge and spin thermoelectric properties of double quantum dots system connected to ferromagnetic leads with collinear magnetic configurations will be studied in the linear response regime. Our results are calculated in a strong interdot coupling regime by taking into consideration all parameters affecting the system such as interaction between dots and their coupling to the leads, intradot Coulomb correlation energy and spin-polarization on the leads. It is found that in the parallel magnetic configuration, the thermoelectric efficiency can reach a large value around the spin-down resonance levels when the tunneling coupling between the quantum dots and the leads for the spin-down electrons are small, which leads to the pure spin Seebeck contribution. As a result, this system can generate a spin-polarized current. The value of the spin figure of merit is enhanced by increasing the spin-polarization and decreasing the correlation energy.
Effect of Different Polar Groups on the Mesomorphic and Physical Properties of Synthesized Schiff Base Liquid Crystalline Compounds
Authors: Khairallah A.Y.
Published: June 2022

Five compounds of calamitic Schiff base with liquid crystalline behavior were synthesized and characterized. The terminal of compounds were substituted with different types of polar groups are - OCH3, -COCH3, - Br, and -COOC2H5, -CF3. The chemical structures of all compounds were characterized by FTIR spectroscopy while the phase transitions and optical textures of the samples were observed by polarized optical microscope. Furthermore, the transition temperatures of the compounds and their liquid crystalline temperature range were determined by using differential scanning coulometer. All compounds showed a higher tendency to exhibit an antiotropic nematic mesophases with different transition temperature range. Moreover, the dielectric and electrical conductivity were investigated. Using different polar groups in the synthesized liquid crystalline compounds is accompanied by significant changes in mesophase thermal stabilities as well as physical properties and all samples are with positive dielectric anisotropy.
Preparation and Characterization of CdS and PbS Chalcogenides Compounds and n-CdS/p-PbS photodiode
Authors: Abdul-Hussein Alaa H.
Published: June 2022

In this study, a chemical bath deposition method (CBD) is used to synthesize CdS nanocrystalline thin films onto FTO substrate using two temperatures of 70 and 80 ºC for 1h of preparation time. PbS nanocrystalline thin films are also prepared using CBD using temperature of 35 ºC for 2h. XRD measurements confirmed that the prepared CdS and PbS thin films are polycrystalline with hexagonal phase for CdS and cubic for PbS. Scanning Electron Microscope images show increasing particles size of CdS thin films with increasing temperature of preparation and the films became more adherent on the substrates without pinholes or vacancies. Optical properties are investigated through UV-Visible Spectroscopy and found decreasing in the transmittance of prepared thin films with increasing temperature. Energy band gap calculated for CdS and PbS nanocrystalline thin films found with values higher than bulk value indicating to due to the quantum confinement effect. Photoluminescence spectra of prepared CdS nanocrystalline thin films appeared sharp emission beak at around 550 nm for all samples indicating high crystallinity. Photoresponse measurements of the fabricated photodetector showed a significant sensitivity to visible light at zero applied voltage, indicating that the fabricated device is a self-powered photodetector. The device was highly photosensitive of 16833, responsivity of 1.44 mAW−1, and a low rise/fall time of 0.284/0.298 s.