bluuebunny/crossref_metadata_2025 huggingface dataset:
AGROBIOLOGICAL ASSESSMENT OF OILSEEDS IN THE CONDITIONS OF THE FOREST-STEPPE OF THE CENTRAL FEDERAL DISTRICT OF THE RUSSIAN FEDERATION
Authors:   V.S. Pustovoit All-Russian Research Institute of Oil crops, Zelentsov S.V. , Karpachev V.V. ,   Lipetsk State regional agricultural experimental station – branch V.S. Pustovoit All-Russian, Tevchenkov A.A. ,   Lipetsk State regional agricultural experimental station – branch V.S. Pustovoit All-Russian, Moshnenko E.V. ,   V.S. Pustovoit All-Russian Research Institute of Oil crops
Published: December 2023

This article presents the results of environmental tests of the most promising very early soybean lines of Krasnodar breeding in the conditions of the Forest-steppe of the Central Federal District of the Russian Fed-eration, which were involved in hybridization. In the obtained hybrid populations of F4 in the conditions of Krasnodar, very early elite plants with a growing period of 90-100 days, plant height of at least 70 cm, and increased productivity were isolated. Their offspring in generations F6 and F7 underwent selection evalua-tion in the latitudinal and climatic conditions of the forest–steppe of the Central Black Soil region on the ba-sis of the Lipetsk Rapeseed Research Institute - a branch of the Federal State Budgetary Research Center V.S. Pustovoit All-Russian Research Institute of Oil crops, Lipetsk. As a result of the conducted studies, it was found that in the typical weather conditions of the Central Black Soil region in 2021 and with the dates of soybean sowing in the Lipetsk region in the 2nd decade of May, the earliest genotypes ripened in late August – early September. The duration of their growing seasons was 96-103 days. In the abnormally cold and rainy conditions of 2022, the growing season of these genotypes increased to 110-123 days. The yield of the earliest of the studied soybean genotypes in the conditions of 2021 varied in the range of 2.04-2.46 t/ha, in the condi-tions of 2022 – in the range of 2.07-2.91 t/ha. A two-year analysis of the productivity of the studied soybean genotypes in various weather conditions allowed us to identify 7 breeding lines that form a yield of more than 2.0 t/ha, both in close to optimal and in abnormally cold weather conditions with excessive precipitation.
THE EFFECT OF AGROCHEMICALS ON THE CLOGGING AND YIELD OF PEAS AND CHICKPEAS
Authors:   Northern Trans-Urals State Agrarian University, Kiseleva T.S. , Rzaeva V.V. ,   Northern Trans-Urals State Agrarian University
Published: December 2023

The article presents data on the contamination and development of the territory and chickpeas in 2022-2023 in the northern forest-steppe of the Tyumen region. The climate of the Tyumen region is continental, with a cold long-lasting environment and a short warm summer. The annual rainfall is 374 mm, of which 232 mm comes out during the growing season of farmed crops. The sum of temperatures above 5 oC varies between 1900-2050 OC, above 10 oC-1860-1940 0C. The average long-term magnificent GTC is 1.1-1.3, which char-acterizes the territory as moderately moist. The postal derivative of the field is the overlying chernozem pull-ing granulometric composition, humus horizon up to 38 cm, straw layer up to 27 cm. The rate of dried 1.3 million /ha, chickpeas 0.5 million/ha of all seeds; the introduction of mineral deposits (ammonium nitrate) with a ban on the planned territory and chickpeas (1.18 and 1.35 t/ha) – 70 kg/ha, effective in this article; according to the search, the cultivation of KRN-4.2, because there is no application herbicides; spraying of herbicides ONSH-600 on peas in the 3-5 leaf infusion phase (at plant heights of 10-15 cm). The Yamal pea variety and the Vector chickpea variety were sown. The general plan is described with protected fields of 0.05 ha. Scalable sequential, returnable threefold. When cultivating peas on bolshay urojainost, Basagran (3.0 l/ha) + Corum with surfactant DASH (2.0 l/ha) + Quantum (2.0 l/ha) was rejected according to the option with the applied Tank shift of herbicides, when cultivating chickpeas with the use of a biological preparation from La (3.0 ha).
BREEDING FOR THE CREATION OF NEW MID-EARLY HYBRIDS OF SWEET CORN IN THE CONDITIONS OF THE FOOTHILL ZONE OF THE STAVROPOL REGION
Authors:   All-Russian research institute of corn, Stavropol region, Sotchenko E.F. , Konareva E.A. ,   All-Russian research institute of corn, Stavropol region
Published: December 2023

The most important task of increasing food production prompts us to pay increasing attention to the cultiva-tion of such highly productive vegetable crops as sweet corn. In conditions of small-scale production, sweet corn is one of the most profitable crops. At the summer market for fresh produce, demand is always high. Over the past decade, the demand among Russian agricultural producers for sweet corn hybrids has in-creased significantly. The State register currently contains about 99 hybrids and populations of sweet corn, including 5 hybrids of ARRSIC breeding – Karamelka (FAO 120), Marmeladka and Serenada (FAO 160), Lakomka, Uslada (FAO 250). This article presents the results of the breeder’s work of the FSBSI ARRSI of corn on new mid-early hybrids of sweet corn creation in the conditions of the Predgorniy district of the Stav-ropol region. The productivity of new sweet corn hybrids for 2022-2023 had appraised. Over two years of re-search in boghara conditions, the ears yield without wrappers at technical ripeness amounted to 16.0-22.8 t/ha. A sweet corn hybrid was identified on the work results base, which meets the standard requirements (ear yield at technical ripeness, plant and of ear attachment height, ear size, grain size, grain color, cob color, as well as resistance to smut damage against a natural background), required for sweet corn of first generation hybrids for their further use in the food industry (canning, freezing). As a result of work on creating new sweet corn hybrids, new lines with high combining ability have been identified.
Bilateral Peritonsillar Abscess in Pediatric Age: A Case Report
Authors: Azizalrahman Amani , Alawadh Areej , Altirkistani Bsaim
Published: December 2023

Background: Bilateral peritonsillar abscesses are a rare occurrence in children. Peritonsillar abscess is characterized by the pushing of the tonsils forward and toward the uvula. Untreated acute tonsillitis can lead to the development of peritonsillar abscesses as an early complication.
Case presentation: The study presents a rare case report of a 5-year-old male with no prior medical conditions presented with a history of fever (38.5°) and a runny nose for the past 2 days. No abnormalities were observed in chest, cardiovascular, abdominal, or central nervous system examination. Nevertheless, the tonsils appeared to be pushed by a mass and the uvula deviated. Computed tomography (CT) revealed enlarged bilateral palatine tonsils with a few small peritonsillar abscesses measuring 0.7 cm. Thus, bilateral palatine tonsillitis with few peritonsillar small abscesses associated with multilevel cervical lymphadenopathy was diagnosed.
Conclusion: The emphasis of the report is the importance of considering peritonsillar abscess as a differential diagnosis when encountering a child with previously reported clinical presentations and characteristics, as in the aforementioned case.
Gender Critique of The Scientific and Medical Construction of the Female Body in Women’s Artworks
Authors: Đurić Dubravka
Published: December 2023

In this paper I will develop a gender critique of scientific and medical idealizations of the human body and its health, which was performed out of gender and feminist studies, pointing also to women’s art. In the discourses of medicine, healthy and beautiful human – and especially the female human – body is revealed as an ideological construction, an affective agent and a biopolitical ideal that controls and regulates gender differences. My intention is to demonstrate that the discourses of medicine, feminism, and art are in a dialogue historically in relation to these topics. Following Tasha N. Dubriwny’s discussion of medical discourse and practice, I will map three phases in the development of Western medical discourses and point to the fact that they are in dialogue with feminist discourses and with the way how art treats and represents beautiful bodies, and/or sick bodies, with particular focus on female bodies. Discussion of the first phase of medical development points to the fact that visual art and photography were used to performatively help doctors to construct the female body as sick and deviant, as Didi Huberman showed. The second phase was the medicalization era, in which human bodies are expected to adhere to a standardized norm. In this period, within the framework of second wave feminism, feminist health activists appeared, forming the women's movement for health. Special attention will be directed to the third phase, the biomedicalization era or inclusion-and-difference paradigm, in which postfeminist discourses appeared and in relation to which I will discuss artworks by Hannah Wilke, Katarzyna Kozyra, and Orlan.
Self-Care: Seeking Queer Liberation from the Medical Gaze and Genetic Fatalism
Authors: Walsh Lyndsey
Published: December 2023

Genetic diagnostics are radically and rapidly changing perceptions of health. Individuals with identifiable pathogenic genetic differences are now being made into cultural mutants. Unlike other forms of embodied difference, these diagnostics rely on a high statistical probability of developing a disease, known as genetic risk. As such, individuals with a mutation are often subjected to perform the same clinical labor as those who are already sick with a disease, which can involve invasive medical surveillance, preventative surgeries, and family planning. Self-Care is my artistic attempt to reckon with these biotechnological ruptures in identity caused by the rising use of genetic diagnostics in medicine. Using my body, Self-Care weaves a narrative about health, gender, and identity that seeks to resist the confines of the medical gaze. The work features a specially designed chest binder housing living BRCA1 mutant breast cancer cells, which allows the artist to take on the caring responsibilities of their cancer before it emerges in their body. Building off the artwork, this paper explores contemporary issues surrounding Hereditary Breast and Ovarian Cancer Syndrome in global healthcare systems. Traversing the boundaries between sick and healthy, male and female, and parent and child, this paper sets out to both present the scholarly research surrounding Self-Care and provide a platform of critical self-reflection for the artwork to question how best we can care for ourselves and others.
An Online Photovoice Study Designed by Researchers from Art and Social Work to Better Understand the Experience of Chronic Pain by Women of Color
Authors: Prophet Jane , Rahman Rahbel , L. Hassett Afton
Published: December 2023

In 1980s British feminist artist-photographer Jo Spence used phototherapy to challenge normative and medicalized constructions of the female cancer patient by documenting her illness and was then employed as a consultant by hospitals who, through her work, recognized the need to change physicians’ practices and attitudes, which objectified patients. Photovoice, a Community Based Participatory Design method where participants take photographs and combine them with short text narratives, is similar to Spence’s artistic method. It has been used widely in health and social work settings. Healthcare professionals are aware of the power of images as catalysts for meaning making in medical encounters with people in pain; as part of multidisciplinary analysis, because images can enhance a person’s sense of agency in relation to their pain, especially in clinical contexts. Photographs can also establish a common ground for discussing meaning, therefore Photovoice can make the hidden experience of pain visible through collaborative photo-texts. These are subsequently shared with other patients and healthcare workers to aid them in specialist consultations.  However, few studies have addressed gender and race-related health disparities in treating chronic pain. This paper draws on the authors’ study with twenty women of color who created photo-text works about their experiences living with and being treated for chronic pain. In this novel online Photovoice study, participants engaged with asynchronous videos created by an artist-professor about the meanings viewers make of a photograph, including how perspective, angle, and lighting can affect the viewer’s emotional response to photographs. Participants then deployed Photovoice through six synchronous sessions led by a social work professor with extensive experience designing and facilitating Photovoice studies. The resulting image-text works by study participants address health inequity and argue for health equity as a hallmark of social justice in healthcare by focusing on exposing and reducing healthcare disparities.
Care to Cure: Voices of Sick Bodies in the film The Good Nurse (2022)
Authors: Bashir Shohib , Mishra Binod
Published: December 2023

In recent decades, the positions of patients have started deteriorating even after getting the right medication for the specific illness. To ponder this issue, the role of nursing cannot be overlooked. A recent Netflix-released movie The Good Nurse (2022), a crime-drama based on the book of the same name by Charles Graeber, delightfully exemplifies the perspective that, on the one hand, showcases the idiolatry and working professionalism of nursing and on the other brings forth the complexities of the healthcare system. This study encompasses Lydia Hall’s ‘Care, Cure, and Core’ theory of nursing to show how these three aspects reverberate the essence of this profession and eliminate the complexities involved with it. It is very important to address this issue, as it is the foundational framework for interacting with patients that helps in amplifying the living condition of patients. Furthermore, this study brings up the significant issue of ‘trust’ that is prevalent in the contemporary health system around the world. The relevancy of these issues is justified through the study of this film that disestablished the canonicity of the medical nursing system and in contrast, shows the astounding professional practice that helps in improving the recovery of patients in a hospital setting.
Transgenic Embryo Implantation Excerpts from The Life Cycle of The Programmed Mouse, an Art and Biology Residency in an Experimental Animal Production and Research Facility
Authors: Zaretsky Adam
Published: December 2023

This is an excerpt from a record of a bioart residency in the transgenic mouse production facility at i3S, University Porto, Porto, Portugal, EU 2022: Art/sci research-creation, field notes and bioart from the i3S transgenic mouse production facility. The transgenic mouse production facility at i3S is an animal facility that breeds specific transgenic mutants for lab research. This means that the mice are genetically modified and bred to produce stable litters of similarly mutant pups. In other words, the mice are genetically modified in such a way that their offspring are altered in a specific hereditary and multigenerational way.

Covering the life cycle of the programmed mouse, we asked for hands-on experience as much as possible and learned through doing/witnessing: mouse sperm/egg collection, cryopreservation, fertilization, embryo mutagenic microinjection, implantation of embryos in a pseudopregnant surrogate, embryo dissection for tissue culture, surgery, breeding, and euthanasia. Delving into software studies, there was an exploration of CRISPR/vector design apps and transgenic animal facility management apps. We also accessed global networks for stable pedigree proof of genomic standardization as well as animal care and use in the transgenic core. Learning that the mice were often disease models, created to infect with live contagious diseases or inborn with developmental disabilities (degenerative enhancements), we arranged for some animal enrichment arts. Learning of the often-difficult life of scientists and graduate students, we also took the time to enrich the scientists with an action painting to live music enrichment lab. This form of in depth and experiential research is an advanced version of medical anthropology or science technology studies field working with subjective, literary, informed, morbid, and humorous artistic outcomes.
Functional and Dysfunctional Relations of Art, Science, and Health
Authors: Šuvaković Miško
Published: December 2023

With this text, I intend to theoretically interpret the relations between historical and contemporary art, science, and health through the modalities of politics, ethics, and aesthetics. The first hypothesis points to the possibilities of the historical construction of discourse and visual representations of confronting the actions of biopolitics, necropolitics, and politics in a critical relationship between art, science, and health. The understanding of biopolitical and necropolitical functions and effects of science and medicine are re-examined, tested, and critically revealed in modern and contemporary artistic research. I will point to different functional and interventional modes of art: art as a symptom, art as a critical practice, art as a subversive practice and, most importantly, art as an emancipatory practice. I am interested in special cases: artistic provocations or subversion of ethical norms, activist questions about universal human and planetary ethical norms, and critical limits of medical morality and ethics.
I INTERNATIONAL SCIENTIFIC AND PRACTICAL CONFERENCE “DOCTORS AND NURSING – MEDICAL FRONT IN UKRAINE AND THE WORLD”
Authors: Pastryk Tetyana , Gershuni Olga , Lazko Alla , Yaremko Alla , Martyniuk Halyna , Yagensky Andriy , Vakin Volodymyr
Published: December 2023

On May 11–12, 2023, the I International Scientific Practical Conference “Doctors and Nursing – Medical Front in Ukraine and the World” took place in Lutsk, Ukraine. The conference was dedicated to the 150th anniversary of the Shevchenko Scientific Society (SSS).
The conference was organized by the Municipal Institution of Higher Education Volyn Medical Institute of Volyn Region Council, in collaboration with Danylo Halytsky Lviv National Medical University, I.Y. Horbachevsky Ternopil National Medical University, Vilnius University (Lithuania), Higher Private Educational Institution Lviv Medical University, the Shevchenko Scientific Society, and Health Tech Without Borders (Switzerland, USA). The conference was held with the support of the State Institution “Center for Nursing Development of the Ministry of Health of Ukraine”. Partners in conference organization also included Volyn Orthodox Theological Academy, Maastricht University (the Netherlands), Volyn Region Emergency Medical Center and Disaster Medicine Municipal Enterprise, German-Ukrainian Association of Nurses, NeanderklinikHarzwald (Germany), “Myloserdia” Association of Volyn Nurses PO and Lviv Association of Allergists, Immunologists, and Rehabilitologists Charitable Organization.
During the course of the event, a total of over 100 speeches were delivered by medical scientists and practicing physicians, as well as researchers in diverse disciplines from Ukraine, the United States, Great Britain, Poland, Lithuania, Germany, the Netherlands, and Switzerland. Workshops were conducted on relevant issues in medical practice in times of war.
A total of approximately 1100 individuals participated in the conference, comprising physicians from diverse disciplines and nurses, emergency medical professionals and disaster medicine specialists, scientific and pedagogical personnel, employees of the State Emergency Service, physical rehabilitation specialists, psychologists, representatives of the clergy and public organizations, and young scientists.
A new interdisciplinary format of scientific dialogue has been started between representatives of medical and nursing specialities, the education sector, psychologists, and clergy. It helps find ways to address relevant issues in the medical sector in complex conditions of the present day.
7TH INTERNATIONAL SYMPOSIUM “SMART LION”. REHABILITATION IN UKRAINE, SEPTEMBER 26, 2023
Authors: Bekesevych Anna , Lazko Alla , Hresko Ihor
Published: December 2023

The seventh international symposium, SMART LION, was held on September 26, 2023. It was to celebrate the 150th anniversary of the Shevchenko Scientific Society and the 125th anniversary of the Medical Commission. The topics concerned the challenges our country faces today. Organizers of SMART LION 2023 are Professors Valentyna Chopyak, Oksana Zayachkivska, and Vassyl Lonchyna. They managed to gather almost two hundred participants offline and over a thousand guests online.

Olena Lazareva, Vira Rokoshevska, Oleh Bilianskyi, Oksana Hdyria, and Oleh Fitkalo delivered their reports on the development of rehabilitation in Ukraine and its main avenues.

The emergence of post-traumatic stress disorder (PTSD) is a critical challenge for contemporary Ukraine and has long been a significant obstacle for global medicine. That is the reason why Oleh Berezyuk, Head of the Mental Health Service of the UNBROKEN National Rehabilitation Center, brought up the matter of difficulties in correctly diagnosing and treating PTSD in the context of a multidisciplinary hospital, while Professor Valentyna Chopyak and MD Svitlana Zubchenko focused the attention of attendees on PTSD immune-rehabilitation.

During the concluding block of the symposium, which focused on the contemporary interpretation of physical therapy and occupational therapy, as well as interprofessional education, communication, and cooperation, attendees were afforded the chance to listen to highly intriguing reports presented by Renata Roman (Canada), Ellen Godwin (USA), Karl J. Sandin (USA), David Omut (USA), and Oksana Zayachkivska (Ukraine, USA).

The scientific event concluded with a round table on the future of physical therapy and rehabilitation in Ukraine, with its outcomes leading to the resolution of the seventh international symposium, SMART LION 2023.
ADVANCES IN IMAGING FOR CLINICAL TRIALS IN RHEUMATIC DISEASES
Authors: Maksymowych Walter P.
Published: December 2023

The successful execution of clinical trials for novel anti-rheumatic compounds is increasingly approaching the limits of what can be achieved using radiographic outcomes for the assessment of disease modification. Moreover, there is a growing need for more objective tools to assess joint inflammation, especially for disorders such as axial spondyloarthritis where spinal symptoms are often non-specific and physical findings may be minimal until later stages of disease. The use of MRI to evaluate inflammation in the synovium and bone marrow as well as erosions in peripheral joints of patients with RA and PsA represents a major new advance that should now be routinely implemented in clinical trials of RA. MRI-based scoring systems have been well validated and demonstrate that, for RA, MRI changes after therapeutic intervention may be observed in a month and precede findings on radiography that only become evident after a year. The assessment of disease activity on MRI of the sacroiliac joints and spine using a standardized and well-validated method, such as the SPARCC instruments, is indispensable to the evaluation of efficacy for new agents aimed at the treatment of spondyloarthritis. Further advances include the use of whole-body MRI evaluation to assess inflammation in both the axial and peripheral skeleton as well as sequences that dispense with the requirement for the use of contrast agents, such as gadolinium, and data processing techniques that permit full automation and absolute quantification. This review will discuss how imaging is transforming clinical trials in rheumatic diseases.
MAST CELLS IN THE MILIEU: A COMPARATIVE STUDY IN THE TONGUE AND LIVER
Authors: Makeyeva Yuliya , Leach Steven T. , Ryugo David K.
Published: December 2023

Mast Cells (MCs) have diverse roles in health and disease. These immune cells migrate in a tissue-specific manner to target sites where they can alert or amplify immune responses through exocytosis of their bioactive granules. Granule exocytosis can be triggered by both external immunological and non-immunological signals. Depending on the local milieu, MCs are highly heterogeneous cells with significant phenotypic plasticity and functional diversity. The aim of this study was to investigate differences in MC populations in the tongue and liver to advance the understanding of how organ-specific location may affect MC phenotypic variance and functions. MCs were investigated using light and electron microscopy in tissues obtained from rats housed in identical conditions. Connective tissue MCs were identified in both the tongue and liver and showed phenotypic differences in secretory activity and granule characteristics. These findings indicate that phenotypic variance depends on tissue location. This knowledge may help develop strategies for preventing or treating diseases.
USING INTRAVENOUS IMMUNOGLOBULIN IN A PATIENT WITH SEPTIC SHOCK AND MULTIPLE COMORBIDITIES: A REVIEW BASED ON A CLINICAL CASE
Authors: Matolynets Nataliya , Rolinski Jacek , Lishchuk-Yakymovych Khrystyna , Tolstyak Yaroslav
Published: December 2023

The review focused on managing sepsis and septic shock patients by administering intravenous immunoglobulins (IVIG). Treatment outcomes and survival prognosis of septic patients were discussed in view of different regimens and dosages of IVIG. The principles of determining the appropriate dosage of IVIG in different medical facilities were compared. Own clinical case of complex treatment of septic shock using IVIG was proposed. The patient experienced a septic shock after transurethral resection of the prostate to treat a prostate abscess. Additionally, the patient was diagnosed with acute cerebrovascular disorder and various cardiovascular ailments, including type 2 diabetes mellitus and stage 2 chronic kidney disease. This septic patient was diagnosed with immunodeficiency disorder with lymphopenia, hypoproteinemia, procalcitoninemia, and significant secondary autoimmune inflammatory disorders. Despite the expected unfavorable prognosis, after comprehensive treatment with early application of moderate doses of IVIG, the patient’s condition stabilized, and organ functions remained satisfactory. Therefore, early administration of intravenous immunoglobulin had a favorable clinical outcome in the treatment of septic shock, thereby indicating the need to utilize a multidisciplinary approach, including involving an immunologist, in managing septic conditions.
CYTOKINE-MODULATING INFLUENCE OF HIPEC ON THE INTRAPERITONEAL HOMEOSTASIS FORMATION IN PATIENTS WITH OVARIAN CANCER
Authors: Fetsych Markiyan , Igumentseva Natalia , Ferneza Severyn , Yarema Roman , Volodko Natalia
Published: December 2023

Background: Ovarian cancer (OC) has the greatest mortality rate among oncogynecological diseases. Most cases are diagnosed at the peritoneal dissemination stage, resulting in radical treatment. Most cases (75%) are diagnosed in III-IV stages at the stage of peritoneal dissemination, making the radical treatment impossible. Intraoperative hyperthermic intraperitoneal chemoperfusion (HIPEC), which has ceased to be an experimental technique over the past decade, is increasingly used among the methods of combating peritoneal carcinomatosis and demonstrates an increase in recurrence-free and overall survival in advanced stages of OC. Nevertheless, certain pathophysiological aspects of the effect of HIPEC on intra-abdominal homeostasis, and therefore on the further course of the disease, have not been elucidated. However, understanding this effect may be the key to the successful application of HIPEC and predicting its efficacy in each case of OC.

Objectives: To access changes in intraperitoneal homeostasis in patients with advanced OC after HIPEC procedure (as a stage of cytoreductive surgery); in particular, to evaluate changes of TNF and TGF-β expression under the influence of HIPEC and systemic chemotherapy in the OC microenvironment.

Materials and methods: The study included 33 OC patients treated at Lviv Regional Cancer Centre in 2016–2020. Twelve of them received HIPEC. The primary tumor cultures and primary cultures of peritoneal mesothelium and macrophages were obtained for all patients. The cytokines TNF and TGF-β activity were determined in their conditional media.

Results: The decrease of TNF and TGF-β concentrations in the drainage exudate after HIPEC was revealed compared with the same parameters in the ascitic fluid before the operation. One-hour hyperthermia of the primary culture of peritoneal ascites-associated macrophages of recurrent OC patients decreased the TNF level in conditional media. A decline was found in 10 out of 12 cases.

Conclusions: HIPEC has a cytokine-modulating effect on the intra-abdominal homeostasis of patients with OC, suppressing TNF expression by peritoneal macrophages. Reduced activity of TNF in supernatants of OC primary tumor cultures was associated with higher sensitivity to chemotherapy.
CLINICAL, ULTRASOUND AND CYTOGENETIC CHARACTERISTICS OF FETUSES WITH INCREASED NUCHAL TRANSLUCENCY THICKNESS IN THE FIRST TRIMESTER OF PREGNANCY
Authors: Prokopchuk Natalia , Nikolenko Marharyta , Lozynska Mariya , Antoniuk Olha , Korinetz Yaroslav , Ivaniv Yuriy
Published: December 2023

Background: Improving programs for early prenatal detection of congenital malformations remains a relevant scientific and practical problem. The prevalence of congenital anomalies in Ukraine is 23.7:1000 among live-born babies, and there is no significant decrease in it. The aim of this study was to compare clinical, ultrasound and cytogenetic data in swollen fetuses with increased nuchal translucency (NT) thicknesses from the group of pregnant women in the first trimester at high genetic risk to optimize the algorithm of prenatal diagnostics.

Materials and Methods: Clinical examinations, ultrasound diagnostics, invasive methods of prenatal diagnostics (chorion biopsy, amniocentesis), genetic testing techniques, such as karyotyping and FISH, genetic counseling and statistical analysis were carried out. The results of complex examinations of 127 fetuses with an increased NT thickness from the group of pregnant women were analyzed. Fetuses were divided into two groups with an NT thickness of 2.5–3.5 mm (group 1) (38 cases) and with an NT above 3.5 mm (group 2)(89 cases).

Results: Among pregnancies with fetuses with an increased NT thickness, there were 65.4% cases of adverse outcomes with chromosomal pathology (69.9%), congenital malformations of non-chromosomal etiology (25.3%) and pregnancy loss (4.8%). The frequency of chromosomal abnormalities in fetuses of group 1 was 55.3% and 41.6% in group 2. Congenital malformations of various systems and organs in fetuses, the most frequent of which were cardiac defects, were diagnosed. The ratio of congenital heart defects in the fetuses of groups 1 and 2 was 23.7% and 43.8%, respectively (p=0.03; OR=0.40).

Conclusion: There is no significant difference between the frequency of chromosomal abnormalities in the fetuses of group 1 compared to group 2, which indicates a high informative value of an increased NT thickness, including the thickness of 2.5–3.5 mm in fetuses in the first trimester as a marker of chromosomal pathology. A significantly higher incidence of congenital malformations of non-chromosomal etiology was found in fetuses with venous duct pathology and NT thickness over 3.5 mm compared to fetuses with the same pathology and NT thickness of 2.5–3.5 mm. Proposed changes to the management algorithm for pregnant women with swollen fetuses include mandatory congenital heart defects screening in the first trimester.
CLINICAL ASPECTS IN TRANSLATIONAL RESEARCH ON GASTRIC TUMORIGENESIS AND DEVELOPMENT OF NEW TREATMENTS
Authors: Andersen Gøran Troseth , Zhao Chin-Mei , Grønbech Jon Erik , Chen Yijiang , Zayachkivska Oksana , Røe Oluf Dimitri , Chen Duan
Published: December 2023

This brief communication presented a dissertation of PhD thesis on translational research using state-of-the-art methods of multi-disciplinary integrations between basic and clinical research and between dry- (computational) and wet- (experimental and clinical) investigations. The findings showed possible causal association between neural innervation and tumorigenesis of gastric cancer via Wnt signaling and metabolic reprogramming within the tumor microenvironment. Accordingly, selective vagotomy, Botulinum neurotoxin type A (injection into the tumor areas), RAD001 (also known as Everolimus), CPI-613 (devimistat) and ivermectin were found to be potential for treatment of gastric cancer. The assessment showed that this translational research approach guaranteed the efficient development of novel knowledge in fundamental medical sciences, and that the identification of the role of vagal innervation and the possibilities of its modulation during gastric tumorigenesis represented valuable contributions to the fields of gastroenterology and cancer research. Possible roles of angiogenesis vs neurogenesis and brain-gut axis would be worth exploring in further research.
Selection of Primer Location for qMSP Analysis of Alu Methylation Level in Vietnamese Patients with Breast Cancer
Authors: Thi Quynh Trang Tran , The Tung Pham , Thi Than Nguyen , Lan Vo Thi Thuong
Published: December 2023

In the mammalian genome, DNA methylation occurs at the cytosine in CpG complexes. Changes in genomic DNA methylation status, reflected by the CpG methylation status of the retrotransposon Alu elements, are closely related to the initiation and development of cancer. Abnormalities in Alu methylation have been documented in many early-stage tumors where the Alu methylation level correlates with cellular malignancy. Therefore, the assessment of Alu methylation level as a biomarker for early diagnosis and prognosis has been of interest in many types of cancer. Our study aims to investigate the nucleotide positions on the CpG-rich sequence of Alu for the design of primers used for quantitative methylation-specific PCR reaction (qMSP). Using two primer pairs designed from the 5' Alu region for analysis of the Alu methylation level in 25 pairs of cancer/adjacent tissue samples of Vietnamese patients with breast cancer, we find out the primer pair that significantly distinguished the Alu methylation status between cancer and adjacent tissue samples. Selecting the right qMSP primer pair will facilitate the profiling of Alu methylation levels in breast cancer samples when compared with non-cancerous samples, thereby determining its potential in becoming an epigenetic marker for early diagnosis, prognosis as well as in supporting breast cancer treatment to be more effective in Vietnam.

Keywords: Alu methylation, breast cancer, primers of qMSP.
Stigma, Help-seeking and Factors Associated with Mental Health Literacy in Adults: A Literature Review
Authors: Bach Nguyen Xuan , Ngoc Bich Nguyen , Hoang Anh Dang
Published: December 2023

The article aims to review domestic and foreign research to provide information about the current condition of two of the three aspects of mental health literacy, namely stigma, and help-seeking, and the related factors to understand impact measures to help improve the adults' mental health literacy. This study uses a literature review method with English and Vietnamese keyword searching on PubMed and Vietnamese journals. Results show that stigma happens to be higher in Asian regions than in Australia, Europe, and America. Reducing stigma will improve treatment effectiveness and enhance the mental health literacy of individuals and communities. Regarding help-seeking, it shows that the rate of seeking help ranges from 28.2% to 76.9%. People with low mental health literacy are often less likely to seek help. Age, gender, education level, income, employment position, marital status, medical history, and alcohol use history are factors related to mental health literacy. Previous studies have shown that people with higher knowledge tend to seek help, while those with less stigma have a higher ability to seek help.

Keywords: Related factors, mental health literacy, adults, stigma, help-seeking.
Traditional culture of the ethnicities of Uzbekistan based on materials from expeditions of Soviet ethnographers in the 1980s.
Authors: Wang Yi Qin , Fisheva Anastasiya Aleksandrovna
Published: December 2023

This article focuses on the reporting materials compiled by ethnographers working at the State Museum of Ethnography of the Peoples of the USSR who in the 1980s participated in expeditions to the Republic of Uzbekistan. They set themselves the goal not only to collect information or artefacts valuable for studying the cultural history of particular region, but also to explore the transformation of national identity, that was a consequence of linguistic, cultural and economic integration of the ethnicities inhabiting Uzbekistan. After many years of expeditions the collections of the Russian Ethnographic Museum were replenished with valuable and unique objects. The article pays attention to corporeal, illustrative, and reporting materials that attest to traditions and innovations in the material culture of modern Uzbekistan, as well as interethnic relations. The authors adhered to the methodological principles of historical anthropology, which focus on the evolution and diversity of societies and social relations. The scientific novelty lies in the fact that, based on the study of sources introduced into scientific circulation for the first time, the authors came to the conclusion that the expeditions not only contributed to the preservation of the material culture of the region under study, but also recorded the difficulties in interethnic relations long before they became part of the official discourse of national policy in the USSR. The national-territorial demarcation carried out by the Soviet government in Central Asia in 1924 took place, for the most part, not in accordance with the ethnicity of the peoples living in the territory, but according to ideological and economic parameters. Consequently such a significant event, regardless of its overall effect, created the preconditions for interethnic problems, which were indicated in the named reports.
Formation and development of criminal liability for crimes infringing on fair competition
Authors: Danilovskaia Anna Vladimirovna
Published: December 2023

The subject of the study is the legal foundations of Russia's criminal law policy in the field of fair competition protection in their historical development, namely the sources of Russian legislation of the XVIII-XXI centuries, containing grounds for criminal liability for encroachments on fair competition, legal acts regulating competitive relations, as well as scientific research by scientists of the XIX-XXI centuries, including dissertations, scientific publications on aspects of legal regulation of competitive relations, criminal prosecution for encroachments on them.The purpose of the work is to identify the historically conditioned attitude of the Russian state towards encroachments on fair competition, their criminalization, penalization and differentiation of responsibility for their commission, systematization of crimes against fair competition, as well as to study the legislative technique used in the formulation of criminal law prohibitions.  The main method of research was the historical method, which allowed us to study the genesis of domestic criminal legislation, which provided for liability for encroachments on fair competition. The logical, comparative method, the method of system analysis, and classification were also used. The main result of the work is the conclusion about the usefulness of taking into account domestic legislative experience in determining the criteria for criminalizing acts that infringe on fair competition, systematizing crimes against fair competition, methods and techniques for formulating criminal law prohibitions against their commission. The novelty of the research lies in the fact that the conducted analysis of domestic legislation can help in substantiating and making decisions of criminal and political significance in relation to understanding the system of crimes against fair competition, criminalization of socially dangerous acts directed against fair competition, their penalization, differentiation of responsibility for their commission, the application of existing criminal legislation and their improvement. The findings can be especially useful in legislative and scientific activities, as well as in the field of education.
Radec Learning and Literacy: Enhancing Students’ Literacy through the Development of Radec Learning Model at Madrasah
Authors: Muhiddinur Kamal  , Shafra  , Elfiani  , Abdulramae Sulonglfiani  , Melyann Melani  , Nofri Andy. N
Published: December 2023

Literacy is one of the important things to be cultivated from an early age, because with literacy the window of the world will open. This research was an effort to foster literacy from an early age through the development of the Radec Learning model at Madrasah Ibtidaiyah. The purpose of this research was to produce a product in the form of developing a learning model using the Radec Learning model. The method used was Research and Development (RnD) to produce certain products and test the effectiveness of these products by adapting the McKenny Model as a stage consisting of preliminary research, prototyping phase, and assessment stage. The results of this study included: 1) The development of the Radec Learning model was significantly proven to be able to develop students’ learning outcomes at MIN 1 Pasaman; 2) This Radec Learning model was declared valid after being validated by the validator; and 3) There was a practical level of practical application of the Radec Learning model, with evidence of its development and increasing student creativity in learning. Thus, the application of the Radec Learning model of learning could develop literacy from an early age and as an alternative in the selection of learning models that would be applied in Madrasah Ibtidaiyah.
Keywords: Radec Learning Model, Radec Learning, Students Literacy
Innovative History Learning through Virtual Field Trips Model
Authors: Moh. Imron Rosidi  , Disman  , Kokom Komalasari  , Erlina Wiyanarti
Published: December 2023

The purpose of this research is to create an innovative history learning model by using a virtual field trip model. The problem will be studied in this study are: (1) what is the essence reality in learning history? (2) how is the application of the virtual field trip model to a history learning? Research method selected for this study is a literature study where the data material needed are obtained from books, journals, encyclopedias, articles and others. According to the study result, it defines a learning history is a teaching and learning activity regarding past events with conveyed meaning for the present. Within its development process in responding to the Covid 19 pandemic, an innovative virtual field trip model was created and designed to make students able to play an active role in the history learning process which can be seen from the following syntax: (1) Determining the learning materials, (2) Guiding the group/individual investigations, (3) Presenting the result of students’ investigation and (4) Evaluation. Keywords:  Learning Model, History Learning, Virtual Field Trips
Student Engagement Models: Parental Support, Academic Self-Efficacy, and the Teacher-Student Relationship
Authors: Eny Purwandari  , Khoirunnisa
Published: December 2023

Student engagement is the basis for academic and social success in online learning. The study aimed to examine the measurement and structural models and empirically test the relationship between parental support, academic self-efficacy, teacher-student relationship, and student engagement. The number of research samples was 323 junior high school students in Cirebon City, coming from 4 schools (public and private) which were obtained by multistage cluster random. The instrument uses a scale of student engagement, parental support, academic self-efficacy, and teacher-student relationship. Data analysis using structural equation modeling (SEM) with LISREL 8.8 program. The results showed that the overall fit test of the student engagement model was fit: Chi-square (p) = 146.71 (.00), df = 59, RMSEA = .068, SRMR =.05; CFI = .99, NNFI =.99; GFI = .93. The student engagement model is supported by parental support, academic self-efficacy, and the teacher-student relationship. The findings have contributed to strategies for increasing student engagement through parental support, teacher-student relationships, and academic self-efficacy.  Keywords: Student Engagement Model, Parental Support, Academic Self-Efficacy
ANTIOXIDANT ACTIVITY AND PHYSICO-CHEMICAL PROPERTIES OF GREEN SYNTHESIZED ZINC OXIDE NANOPARTICLES USING ERUCA SATIVA LEAF EXTRACT
Authors: Mohammed Lina Y.
Published: December 2023

The aim of this work is to synthesize zinc oxide (ZnO) nanoparticles from Eurca Sativa water extract which is a medicinal plant cultivated in home gardens in Kurdistan Region-Iraq. The biosynthesis of nanoparticles has been extensively studied due to their numerous applications. Among them, zinc oxide nanoparticles (ZnO NPs) have gained significant attention for wide range of its applications. To investigate the optical, chemical, structural, and morphological properties, different techniques; UV-VIS spectrophotometer, Fourier Transform Infrared Analysis (FT-IR), X-ray diffraction (XRD), Field emission scanning electron microscopy (FESEM), Energy-dispersive X-ray spectroscopy (EDX) were used.
The results revealed that typical ZnO absorption spectra exhibit a well-defined exciton band at 371.6 nm that is near the bulk exciton absorption of ZnO (373 nm) with an energy band gap of 3.029 eV, confirming the production of ZnO nanoparticles. FTIR study demonstrated the existence of bioactive compounds such as flavonoids, polyphenols, tannins, and saponins that can function as reducing and capping agents of ZnO nanoparticles. FESEM picture revealed that ZnO NPs show spherical morphologies with an average diameter of 71.07 nm.  The antioxidant activities of biosynthetic ZnO NPs were studied using non-enzymatic methods; 2,2-diphenyl-1-picrylhydrazyl (DPPH), reducing power assay, and total antioxidant activities. The results showed that the biosynthesized ZnO-NPs nanoparticles had significant antioxidants compared with ascorbic acid as a reference. The obtained results showed that the present method is eco-friendly, less cost-effective, and safe for human health and this method plays a vital role in the industrial and biomedicine fields.