bluuebunny/crossref_metadata_2025 huggingface dataset:
Phytolacca decandra 30 CH dilution as an anticancer agent in murine mammary adenocarcinoma model
Authors: Nogueira Luciana , Cavalho JosÃ© Renildo , Costa Dalboni Luciane , Neves Cardoso ThaynÃ¡ , Konno Fabiana Toshie , Bonamin Leoni Villano , Perez Elizabeth Cristina
Published: August 2021

Homeopathy is an effective and safe therapy that provides better quality of life and reduces the adverse effects of conventional therapy used in different diseases. However, there are few published studies showing effects of homeopathic medicines in cancer models. Considering the principle "like cures like" the Phytolocca decandra causes similar symptoms to those presented in cancer subjects. Therefore, the aim of this study was to evaluate the effects of homeopathic preparations of Phytolacca decandra in the development of murine mammary tumor. For this, 4T1 mammary adenocarcinoma cells were inoculated subcutaneously in the inguinal breast of female BALB/c mice. Then, mice were blind treated with water containing only vehicle (control) or vehicle with Phytolacca decandra dilutions (6CH, 12CH, 30CH or 200cH). Tumor growth was monitored in alternated days during 21 days after tumor cells inoculation. Then, mice were euthanized and tumor, spleen, and lungs were removed to histological analyses. Results showed that animals treated with 30CH when compared with other groups exhibited tumor growth delay and smaller tumor weight, less vascularization and smaller relative weight of the spleen and pulmonary metastases. Together, results obtained in this pilot study demonstrated that treatment with Phytolacca decandra 30CH dilution induces delayed of breast tumor growth suggesting that this dilution may be a promising alternative therapy in the treatment of breast cancer.
Evaluation of Leishmania infantum 30x biotherapy effects in the prevention and treatment of visceral leishmaniasis: in vivo and in vitro studies
Authors: Cajueiro Ana Paula Bacellar , Barbosa Gleyce Moreno , Homsani Fortune , Matos Ana Paula dos Santos , Rodrigues Igor Almeida , Bonamin Leoni Villano , AraÃºjo Silvana Marques , Do Nascimento Katia Fialho , Buchi Dorly de Freitas , Gomes Nelson BrÃªtas de Noronha , Goma Ester Puna Puna , Dos Santos Hilton AntÃ´nio Mata , Castelo-Branco Morgana Teixeira , Toma Helena Keiko , Oliveira Adriana Passos , Pyrrho Alexandre dos Santos , Holandino Carla
Published: August 2021

Background:

Leishmaniasis is a serious public health problem especially in developing countries [1]. The therapeutic potential of biotherapics against several microorganism has been described in vitro [2,3] and in vivo studies [4,5,6,7,8,9]. Considering the resistance of leishmaniasis to conventional treatment as well as previous studies with biotherapic, we evaluated the effects of Leishmania infantum 30x (BioLi30x) biotherapy.

Aim: evaluate the antileishmanial effects of BioLi30x in in vivo and in vitro models.

Methodology:

The in vivo experiments were performed using BALB/c mice (n=138), divided into 8 groups: G1-healthy, G2-infected with L. infantum, G3-BioLi30x pre-treated, G4-BioLi30x pre/post-treated, G5-BioLi30x post-treated, G6-H2O30x post-treated, G7-Antimonium crudum 30x post-treated and G8-GlucantimeÂ® post-treated. After 49 days of treatment, the animals were submitted to euthanasia (ethical approval ECUA/UFRJ/066/14). Liver and spleen histological changes were evaluated, and serum samples were aliquoted and storage at -20Â°C for cytokine assays. The in vitro assays were performed using RAW 264.7 macrophages treated with BioLi30x and infected with L. infantum. The morphological aspects were evaluated by scanning electron microscopy (SEM), and the nitric oxide (NO) release was quantified in the supernatant of infected macrophages.

Results:

The histological analysis from 4 independent experiments showed livers with normal appearance (G1); periportal chronic hepatitis (G2,G4,G5,G8); discreet (G3,G7), moderate (G4,G5,G6), and severe (G2,G8) vacuolar hydropic degeneration; congestion and neutrophilic inflammation (G2,G4,G5,G6,G8), and possible amastigotes within macrophages (G2-G8). Spleens presented healthy appearance only in G1. All treated animals presented histological alterations, with different lesions severity, which involved spleen pulp hyperplasia with moderate disruption (G2,G8), as well as megakaryocytes and macrophages proliferation (G2- G8). SEM analyses showed BioLi30x treatments induced significant protozoan morphology alterations when compared to H2O30x. Besides, a 19% increase in the NO release was detected in RAW supernatants, when compared to H2O30x.

Conclusions:

BioLi30x and Antimonium crudum 30x modified the infection animal process, involving several cellular mechanisms as well as different histological damage. The in vitro experiments will be repeated in order to confirm these preliminary results.
Multicenter project Brazil-Italy: physicochemical analysis of Zincum metallicum and lactose in dynamized mixtures
Authors: Holandino Carla , Oliveira Adriana Passos , Homsani Fortune , Fernandes ThaÃ­s , Zanetti Michelle Rodrigues de Lima , De Paiva Juliana PatrÃ£o , Siqueira Camila Monteiro , Da Veiga Venicio Feo , Garcia Sheila , Colli Leticia , ViÃ§osa Alessandra L , Brito Luciana Macedo , Rossi Andre Linhares , Picciani Paulo Henrique , Araujo Silvana Marques , Bonamin Leoni Villano , Bellavite Paolo
Published: August 2021

Background: The use of sensitive techniques can be useful to increase the understanding of homeopathic systems behavior.

Aim: To analyze physicochemical properties of Zincum metallicum and lactose mixtures prepared according to Brazilian Homeopathic Pharmacopeia.

Methodology: Zincum metallicum was prepared using lactose as vehicle, from 1 to 3 cH, and from 1 to 6dH. All samples including respective controls (dynamized lactose) were analyzed by Atomic Absorption Spectroscopy (AAS), X-ray Diffraction (XRD), Transmission Electron Microscopy (TEM) with X-Ray Energy Dispersive Spectroscopy (EDX), Scanning Electron Microscopy (SEM), and Differential Scanning Calorimetry (DSC).

Results: AAS analysis showed the dynamization process decreases zinc concentration in a proportional manner to the increase of homeopathic potencies. Quantities of 4ppm and 132 ppm of zinc were detected in 6dH and 3cH, respectively. XRD analysis showed crystalline form of lactose was not modified by dynamization. Amorphous lactose spheres were observed by TEM in all samples, with mean size ranging from 800 to 200 nm. EDX obtained in the TEM confirmed zinc presence throughout the amorphous matter and the absence of individualized zinc crystalline particles. These results are in accordance with XRD which showed absence of zinc diffraction peaks, in all lactose samples containing zinc suggesting this metal could be modified from crystalline to amorphous state, and consequently adsorbed into lactose molecules. SEM structural analysis of lactose and zinc (1cH) samples using BSE detector showed no zinc metal grains confirming XRD and TEM results. DSC analyses presented statistical significance differences (p
Guest Editorial
Authors: Brands Martien
Published: August 2021

The 30th anniversary of the GIRI meetings was celebrated in Amsterdam, - an old city where RenÃ© Descartes resided 500 years ago, who framed the distinction between â€˜matters realâ€™ and â€˜matters mentalâ€™, a separation that still haunts Western science. Besides, Descartes originated from France where the GIRI was established in 1987 by a group of â€˜material scientistsâ€™ â€“ so history made full circleâ€¦

...So this meeting brought together some key jigsaw pieces that explain the effect of highly diluted solutions in the human ill organism. And I mention â€˜illâ€™ here on purpose, as the sensitivity of an ill person is totally different from that of a healthy person. I hope this inspiring meeting will stimulate even more cooperative projects than already feature the GIRI.
IN VITRO STUDY ACTIVITY PROLIFERATIVE FIBROBLAST HUMAN SUBMITTED TO TREATMENT ZINCUM METALLICUM AND CALENDULA OFFICINALIS IN ULTRA DILUTIONS HOMEOPATHIC
Authors: Cavalaro Victor
Published: August 2021

Cicatrization can be divided into three phases: inflammation, fibroblastic, maturation and remodeling [1]. The extracellular matrix may be replaced by a stronger and more elastic connective tissue. In a scar collagen is the major component of the mature connective tissue [2]. In homeopathic area, the greater is the investigated segment ultra dilutions [6]. However, little research has been done to explore the effect of dynamized drugs in in vitro cell culture [4]. Using the Zincum metallicum 6CH and Calendula officinalis 6CH applied independently in different concentrations in fibroblast cultures sought to determine the increase in proliferative activity using techniques such as IC50, MTT, flow cytometry and quantification of collagen. As expected from the literature, ie both homeopathic according to the literature are used for treatments that Require skin healing, both showed increased proliferative activity, having Calendula most cellular response, presenting as cell cycle stimulating checked via flow cytometry.
Novel heterococcolithophores, holococcolithophores and life cycle combinations from the families Syracosphaeraceae and Papposphaeraceae and the genus Florisphaera
Authors: Keuter Sabine , Young Jeremy R. , Koplovitz Gil , Zingone Adriana , Frada Miguel J.
Published: August 2021

Abstract. Coccolithophores are a diverse group of calcifying phytoplankton, which are responsible for a large part of the modern oceanic carbonate production. Here, we describe novel or poorly known coccolithophores and novel life cycle combination coccospheres detected in samples collected either in the Gulf of Aqaba in the northern Red Sea or in the Gulf of Naples in the western Mediterranean. These include Syracosphaera winteri, for which detached coccoliths have previously been recorded but both a formal description and taxonomic affiliation were lacking, and five undescribed sets of combination cells linking HET and HOL forms for S. pulchra, S. mediterranea, S. azureaplaneta, S. lamina and S. orbicula. We also propose the replacement name S. kareniae for the fossil species Deutschlandia gaarderae. We describe a new species of the genus Ophiaster, O. macrospinus, displaying a unique morphological and ecological distribution as well as putative combination cells of two variants of the deep-dwelling Florisphaera profunda, which provide new insights on the affiliation of this genus within the Calcihaptophycideae. Additionally, in the family Papposphaeraceae we detected a new species, Pappomonas vexillata, and combination cells of Picarola margalefi and of a species resembling Papposphaera arctica. Finally, we detected three novel, unpaired holococcolithophore forms (Calyptrosphaera lluisae, Calicasphaera bipora and one form designated as Holococcolithophore A). Overall, this set of novel observations and ensuing discussions provide further insights into the diversity, evolution and life cycle complexity of coccolithophores in the oceans.
Fundamentos político-pedagógicos da BNCC: considerações sobre o Estado educador e a produção de hegemonia
Authors: Giareta Paulo Fioravante
Published: August 2021

Este artigo objetiva fazer um exercício teórico de análise das características político-pedagógicas da Base Nacional Comum Curricular (BNCC), como expressão do Estado na qualidade de mediador de relações hegemônicas no contexto brasileiro. Metodologicamente, este trabalho estrutura-se a partir do materialismo histórico-dialético, fundamentado na concepção teórica de Antonio Gramsci, que compreende o Estado como organismo complexo e afeito técnica, ética e intelectualmente à racionalidade hegemônica. O trabalho indica que a BNCC, como ferramenta de intervenção política, portanto pedagógica do Estado, tanto incide sobre os processos de construção de consensos com marcada fidelidade à sociabilidade hegemônica, quanto busca disciplinar de forma direta a prática educativa, o que significa incidir sobre as próprias intencionalidades da comunidade educativa, consequentemente no controle e no disciplinamento das forças que indicam caminhos para a construção de outras experiências de sociabilidade que não a hegemônica.
MÉTODO IDEOGRÁFICO
Authors: Dickmann Ivo , Dickmann Ivanio
Published: August 2021

O presente artigo apresenta uma metodologia de trabalho na Educação popular criada pelos autores chamada de Método Ideográfico. Baseado na experiência dos autores e com referencial teórico freiriano, o método está dividido em três partes: o quadrado doxológico, o triângulo epistemológico e o círculo metodológico. A intencionalidade é problematizar o conhecimento da experiência (doxa) e avançar para um saber mais elaborado (episteme), tendo o diálogo como metodologia problematizadora. Conclui-se que o Método Ideográfico é uma ferramenta para problematizar as situações-limite das classes populares na construção de alternativas de inéditos viáveis em vista da transformação da realidade oprimida.
The Influence of Service Quality and Company Image to Customer Loyalty through Corporate Customer Satisfaction on XXX Group
Authors: Rahayu Hastuti Sri , Ginting Paham , Fawzeea Beby Karina
Published: August 2021

To increase economic growth through infrastructure development in Indonesia, the Government is accelerating projects that are considered strategic and have high urgency to be realized in a short period. XXX Group which is one of the large cement companies in Indonesia is a great opportunity because PSN will use a large amount of cement in its work. But XXX Group is not alone in the cement market, many competitors compete to get PSN (Project National Stategic), so each company uses a surefire strategy in marketing its products both in terms of service quality and by improving the company's image in the eyes of customers so that customers are satisfied with XXX Group and will increase customer loyalty. The purpose of this research is to know and analyze the influence of service quality and company image directly on customer loyalty and the indirect influence of service quality and company image on customer loyalty through customer satisfaction at XXX Group. The type of data used is quantitative in the form of primary and secondary data. The population of this study is a company that makes purchases as many as 42 projects and the sample recall used is a saturated sample so that all populations are used into samples. The data analysis method used is to use the structural equation model by using Smart PLS 3.0 program. The results showed the quality of service has a positive and significant effect on customer loyalty, the company's image has a positive and significant effect on customer loyalty. The quality of service has a positive and significant effect on customer satisfaction, the image has a positive and significant effect on customer satisfaction. Customer satisfaction has a positive and significant effect on customer loyalty. Customer satisfaction mediates the influence of service quality and company image in shaping customer loyalty. Coefficient of determining the influence of service quality and company image on customer loyalty (R2) by 97.6% and coefficient of determining the influence of service quality and company image on customer loyalty through customer satisfaction (R2) by 99.0%

Keywords: Service Quality, Company Image, Customer Satisfaction, Customer Loyalty.
Risk Management Model using Cause and Effect Analysis in Industrial Building Project
Authors: Oktaviani Oki , Susetyo Budi , Kusumo Bintoro Bambang Purwoko
Published: August 2021

The purpose of this study is to determine the main potential risks that occur in the design planning stage of a construction project, especially in an Industrial Building project. Based on the available literature and the experiences of other authors and practitioners, a list of potential risks was developed. Risks events were initially categorized into technical, project management, commercial and external categories. Risks are evaluated by professional practitioners who have experience in construction projects. The evaluation includes the expected likelihood of the event and its impact on changes in scope of work. This study considers each risk among owners, consultants, contractors and others. The data collected were analyzed qualitatively and quantitatively to assess the severity and impact of the event. The recommended responses to major risks are introduced in this study.

Keywords: risk management model, planning stage, industrial building.
Analysis Public Transportation City of Dili to Improve Service with Users Characteristics
Authors: Pereira Florentino , Widyaningsih Nunung , Dwiatmoko Hermanto
Published: August 2021

Many public transport drivers in City of Dili do not apply various regulations from the government. Located on Becora-Baidi, Becora-Bidau, and Tasi Tolu-Bidau Road. This causes congestion and traffic accidents, and impact on economy. The purpose of study is to determine the trip generation model and its factors, city transportation service performance, and how to formulate TDM concept in public transport. The survey conducted was daily volume of public transport, questionnaires, and interviews 2020. Looking for value of angkot generation with instrument test and multiple regression (IBM SPSS 22). To analyze services used parameters and Severy Index. Then, concept of Transportation Demand Management (TDM) with Guttman Scale. After analyzing, the trip generation value, Y = -1,3920 + 0,0275.X1 + 0,4958.X2 + 0,1734.X3 – 0,0601. X4 - 0,0657.X5 - 0,0001.X6 - 0,0193.X7 - 0,7670.X8 + 0,8801.X9 + 0,6721.X10 + 0,1058.X11, positive value is factor that most influences the respondent's decision to trips using public transportation: gender (X1), age (X2), job (X3), duration of trip (X9), number of passengers (X10), and waiting time for public transportation (X11). However, in service level is still “low” category. Then, for TDM concept gets 87% in 51%-99% range. Means that angkot users agree, if TDM concept is propose to the government of Dili City, and public transportation will be better in the future.

Keywords: Trip Generation, Public Transportation Mode, Public Transportation Services, Transportation Demand Management, TDM.
The Effect of Digital Service Quality (BRIMO) on Customer Loyalty through Customer Trust and Satisfaction on COVID-19 Situation (Pt Bank Rakyat Indonesia Medan Regional Office)
Authors: Siagian Martin , Rini Endang Sulistya , Situmorang Syafrizal Helmi
Published: August 2021

Advances in information technology and the widespread use of the internet have changed the method of service delivery. Banks now provide their services through electronic banking (e-banking) channels. Personal computers and cell phones are media where customers can use e-banking services, with the terms “online banking”, “internet banking” and “electronic banking” being used interchangeably. BRImo is the latest application from BRI Mobile that combines the functions of mobile banking, internet banking, and electronic money or Tbank into one application with a more complete and attractive transaction menu, only by using a cellphone they can make transactions without having to go to the BRI office to reduce mobility and the spread of the Covid-19 virus in a pandemic situation. In the period from 2018 to 2020, there was an increase in BRImo application users from 384,412 people to 827,759. but not comparable to the large number of deposit customers of Bank BRI Medan Region, in 2020 only 14.43% of the 5,735,381 customers of Bank BRI Medan Region who use BRImo with an average transaction of 122 times per customer per year. Phenomenon which often happens to BRI Bank customers to the BRImo application, either directly or indirectly, such as the quality of digital services provided to customers who have not been satisfied by customers so that it has an impact on customers' decisions not to return to transactions using BRImo and the impact of these problems will decrease the number of transactions and a decrease in fee-based income in the online banking digital service application sector. The purpose of this study was to analyze the effect of BRImo's digital service quality on customer loyalty through customer trust and satisfaction in the Covid-19 situation at PT. Bank Rakyat Indonesia (Persero) Tbk Medan Branch Office. The population of this study is customer savings deposits, not corporate customers (group accounts), with the criteria of a sample of customers who use the BRImo application more than once with a total sample of 400 respondents. The sampling method used is purposive sampling; data analysis is carried out through PLS-SEM using the SmartPLS 3.0 program. The results of the study indicate that the quality of BRImo's digital services directly has a positive and significant effect on customer loyalty through customer trust and satisfaction.

Keywords: BRImo Digital Service Quality, Customer Loyalty, Customer Trust, Customer Satisfaction.
Analysis of the Effect of Competence and Soft Skill on Employee Performance with Job Satisfaction as Intervening Variable at the Regional Social Services of South Tapanuli Regency
Authors: Ramadhan Hariawan , Lumbanraja Prihatin , Sinulingga Sukaria
Published: August 2021

Efforts to improve the performance of local governments are a challenge for regional work units to improve the welfare of local people. The performance of public services in South Tapanuli which still looks unprofessional does not just happen, but is a consequence of the existence of a bureaucratic design that is not prepared as a public servant. Service in the social sector is one form of public service that is very important. Some people who need services complain because the services at the Regional Social Service Office of South Tapanuli Regency are not yet optimal. As a result, the implementation of the main tasks and functions of the Regional Social Service of South Tapanuli Regency cannot be achieved optimally. Therefore, it is important to see how competence and soft skills through satisfaction improve performance at the South Tapanuli Social Service. The purpose of this study was to analyze the effect of competence, soft skills on employee performance through job satisfaction as an intervening variable at the Regional Social Service Office of South Tapanuli Regency. The population of this research is ASN who work in the Regional Social Service of South Tapanuli Regency, amounting to 30 people. Data analysis is descriptive analysis and path analysis using SPSS software. The results showed that competence and soft skills directly had a positive and significant effect on job satisfaction, then competence, soft skills and job satisfaction also had a positive and significant effect on employee performance. Indirectly, job satisfaction is able to positively and significantly mediate the relationship between competence and soft skills variables on employee performance.

Keywords: Competence, Soft Skill, Job Satisfaction, Employee Performance.
Enhance Education Child to Build Habit and Character
Authors: Nofianti Rita , Widya Rika , Rozana Salma
Published: August 2021

The risks involved in confronting the challenges of globalization are very high. Today, children's knowledge of the world without equality is not a luxury but one obligation. Improving the professionalism of teaching faculty and caregivers involved in early childhood education is extremely important because early childhood is a critical year for children's development and hence their readiness to trace the realm of formal schooling and adult life. This paper described As recognized through studies; early childhood education impacts their overall development, whether physical, social, emotional, and intellectual, influenced by the quality of Kindergarten programs presented and teachers educating through the curriculum offered and the teacher's competence.

Keywords: development, education, change habit.
The Effect of Neuropeptide Y (NPY) rs 16147 Gene Polymorphism on the Blood Pressure of Chronic Kidney Disease Patients and Control Healthy in Medan, Indonesia
Authors: Pardamean Gabriel , Muzasti Riri Andri , Nasution Syafrizal
Published: August 2021

Introduction: Chronic Kidney Disease (CKD) is a pathological condition that occurs gradually and is irreversible, characterized by structural and functional abnormalities in the kidneys that lasts for more than three months. The C allele in the Neuropeptide Y (NPY) RS16147 gene is closely related to an increase in the incidence of hypertension, a decrease in glomerular filtration rate, and an increase in total cholesterol levels in CKD patients.
Objective: To determine the effect of the NPY RS16147 gene polymorphism on the blood pressure of chronic kidney disease patients and control healthy in Medan Indonesia.
Methods: This study is an analytical study with a case-control design at the Haji Adam Malik General Hospital Medan from July to August 2020. All subjects had Deoxyribonucleic Acid (DNA) analysis using Polymerase Chain Reaction Restriction Fragment Length Polymorphism (PCR-RFLP) method.
Results: We obtained 100 study subjects, 43 was CKD patients with dialysis, 31 CKD patients without dialysis, and 26 control healthy groups. In this study, there were differences in the trend genotypes of NPY RS16147 polymorphism with the incidence of CKD and control healthy. We obtained a significant difference the mean systolic blood pressure patients with genotypes TT (139,05±21,42) and TC/CC (151,32±22,26) as evidenced by the value of P = 0.00 (≤0.05). The presence of the "C" allele in the NPY RS16147 gene sample increased blood pressure in all study subjects significantly (P=0.028; ≤0.05).
Conclusion: the "C" allele in the NPY RS16147 gene affects systolic blood pressure.

Keywords: NPY RS16147 polymorphism, Chronic kidney disease, Blood pressure.
Analysis of the Impact of the Presence of PT. Martabe Gold Mine Batangtoru on the Level of Welfare of the Community Batangtoru South Tapanuli Regency
Authors: Hutasuhut Khairul Ali , SU HB. Tarmizi , . Rujiman
Published: August 2021

This research was conducted to determine the impact of the existence of PT. Martabe Batang Toru Gold Mine on the level of community welfare in Batang Toru District, South Tapanuli Regency, by comparing the situation before and after the existence of the mine in the 2011-2021 period. The population in this study is the community of Batang Toru District which consists of 11 villages, with a population of 17,379 people. The sample in this study amounted to 100 people who were determined using the Slovin formula with a 90% confidence level. The types of data used in this study are primary and secondary data. The analysis in this study uses the mean difference test and partial t test using SPSS 23. The results in this study indicate that the existence of mining has a positive impact on the welfare of the people of Batang Toru District.

Keywords: PT. Martabe Batangtoru Gold Mine, Average Difference Test, t Test, Community Welfare.
Confluencia de saberes
Authors: Aballay Silvia , Avendaño Manelli Carla
Published: August 2021

Confluencia de saberes constituye un “aporte de aportes”. Es un libro que agrupa, congrega, reúne experiencias documentadas del proceso de institucionalización de la primera carrera Universitaria de Música Popular de Argentina y de Suramérica. La Universidad Nacional de Villa María, (provincia de Córdoba) abrió sus puertas en 1997 y desde su Proyecto Fundacional se impuso aportar al sistema de Educación Superior nuevas e innovadoras carreras de grado. La Licenciatura en Composición Musical con orientación en Música Popular está formando profesionales que sintetizan campos tradicionalmente excluyentes: la Academia y la Música Popular. Sustentado en la historia de la institución, en su Proyecto Fundacional y en los tres pilares universitarios: docencia, investigación y extensión, Confluencia de saberes nos introduce en los primeros años de una propuesta de formación superior que cambió la conceptualización del profesional de la Música Popular.
Editar: Un oficio
Authors: Gazzera Carlos
Published: August 2021

Este libro no es un intento de reflexión teórica ni académica sobre la edición en general ni la edición universitaria en particular. Me gustaría tener la inteligencia y la voluntad para concretar tal empresa. Pero dada su complejidad, importancia y relevancia con mis escasos conocimientos sobre tantas variantes, creo que esa es una tarea para que la emprenda un colectivo de editores, investigadores, académicos e intelectuales a los que, de ningún modo, podría aspirar a reemplazar o sustituir. En todo caso, este libro es un intento mucho más humilde, más personal –si se quiere, más íntimo–, en el cual pretendo exponer lo que he ido acumulando como “saber hacer” a lo largo de mis últimos años conduciendo eduvim. Tampoco es un manual puro y duro (si por esto se entiende un recetario de fórmulas más o menos mágicas en las cuales el lector puede confiar) que indica procesos a implementar para resolver problemas o hacer funcionar una editorial. Sin embargo, sí tiene de “manual” el concepto más “blando”: aquello de que su discurso pretende ayudar a pensar los procesos y su implementación y a estimular al lector a buscar y asumir nuevas metodologías que funcionen en otro sello. Por eso, escribo este libro como un racconto en voz alta, no solo dirigido a mis colegas sino también a todos aquellos que desconocen el trabajo de una editorial: porque me gusta pensar en una comunidad de lectores dispuestos a discutir conmigo para demostrar que tal o cual concepto/idea/proceso están equivocados o son perfectibles. Creo que si esto ocurriera, las páginas de este libro estarían mucho más que justificadas.
	Using a Science Literary Lens to Conceptualize Anxiety Around COVID-19: Strategies for Human Services Professionals
Authors: Dahl Heather , Vo Tina , Huerta Margarita
Published: August 2021

Amid the COVID-19 global pandemic, Human Services Professionals (HSPs) are faced with clients experiencing increased anxiety. HSPs again must broaden their scope of competency to approach this novel, natural phenomenon. Science literacy is the understanding and application of scientific knowledge toward decisions and sensemaking. Although science literacy has many facets, one area, Crosscutting Concepts (CCCs), prioritizes individuals’ funds of knowledge to engage with new phenomena such as COVID-19. This paper describes the role of HSPs responding to COVID-19; provides a conceptual framework through the Ecological Systems Theory, which centers on clients and science literacy; and proposes an integration of science concepts with HSPs’ work. Finally, this paper ends with a vignette collection offering CCCs and resource pathways HSPs can utilize with their clients.
	The Role of Human Services Providers in Addressing Social Determinants of Health
Authors: Robins Lauren , Johnson Kaprea , Gantt Alexandra , Brookover Dana , Suggs Brittany , Jones Janelle , Cannedy Megan
Published: August 2021

Social determinants of health (SDOH) are circumstances in which people grow, live, work, and play. Unmet SDOH needs can adversely affect mental and physical health; however, to date, there are no comprehensive publications that highlight human services providers’ (HSPs’) role in addressing SDOH. This article defines SDOH, delineates HSPs’ role in addressing SDOH, and provides conceptual frameworks that can be used by HSPs to promote SDOH in practice. Special consideration is given for a collective approach that incorporates multiple frameworks to promote holistic practice and health equity. The article concludes with implications for HSPs, administrators, and educators.
	Unique Histories and Unified Futures: Future Trends for Human Service Graduates Entering Psychotherapy Fields
Authors: Drcar Stephanie , Ingersoll Elliott
Published: August 2021

Undergraduate Human Services (HMSV) students are often interested in graduate education and might consider a career as a psychotherapist. The psychotherapy disciplines are primarily composed of psychology, social work, counseling, and addiction counseling, each of which have a unique history regarding their development and approach to clinical work. HMSV graduates aspiring to psychotherapy training need an understanding of the trends influencing the fields of psychotherapy across disciplines. This article presents an overview of trends and factors to prepare the next generation of psychotherapists to work as a unified collective to address societal and individual challenges.
An Overview on Estimation of Lacidipine from Bulk and Formulation
Authors: Dighe Nachiket S. , Bhosale Mayur , Gaikwad Pallavi B.
Published: August 2021

Lacidipine is a calcium channel blocker used in treatment of cardiac arrhythmia. Several methods had been reported for the estimation of lacidipine from bulk and formulations. Here in this an attempt is made to summarize the different methods used along with their specifications. Every method reported for the analysis had its own advantages over the other methods. As per the industrial scalability HPLC is the most useful and effective method for the estimation of Lacidipine from bulk and formulations.
Հեգելը արվեստի դերի մասին (նվիրվում է Հեգելի ծննդյան 250-ամյա հոբելյանին)
Authors: Ասատրյան Գրիգոր
Published: August 2021

Հեգելը, մեր ժամանակների բառապաշարով արտահայտված` արվեստի ժողովրդայնության ջատագով էր` գտնելով, որ «Արվեստը գոյություն ունի ոչ թե փոքր, նեղ շրջանակի, ոչ թե փոքրաթիվ շատ կրթված մարդկանց, այլ ամբողջ ժողովրդի համար` ընդհանուր առմամբ»: Արվեստի ստեղծագործություններում, ըստ Հեգելի, ժողովուրդները ներդրել են իրենց ամենաբովանդակալի ու ամենավսեմ ներքին մտահայեցողություններն ու պատկերացումները: Արվեստը հաճախ որպես աղբյուր, իսկ որոշ ժողովուրդների մոտ` որպես միակ աղբյուր է ծառայում` նրանց իմաստությունն ու կրոնը ճամաչելու համար: Հեգելը նման առաքելություն էր բաժին հանում արվեստին` կրոնի և փիլիսոփայության հետ համահավասար: Սակայն արվեստը, ըստ նրա, ունի նաև էական յուրահատկություն, և դա այն է, որ նա նույնիսկ ամենավսեմ առարկաները մարմնավորում է զգայական ձևով` դրանք ավելի մերձեցնելով այդ արտահայտման ձևերի էությանն ու բնույթին, զգայություններին և ապրումներին:
Hegel was an advocate of the national spirit in art. In his view, “Art does not exist for a not numerous, small and narrow circle of highly educated people, but for the nation as a whole”. According to Hegel, peoples put their most meaningful inner contemplations and imaginations into works of art. Art often serves as a key, in some peoples – as the only key to understanding of own wisdom and religion. Such mission is imparted by Hegel to art – on a par with religion and philosophy. Meanwhile, according to Hegel, the distinctive feature of art is that it embodies in sensuous form even the most sublime truths, bringing their essence and nature still closer to sensations and emotional experiences.
PENGARUH ASOSIASI MEREK, KESETIAAN MEREK, KESADARAN MEREK, DAN CITRA MEREK TERHADAP EKUITAS MEREK PADA PENGGUNA SMARTPHONE OPPO
Authors: Lego Yenny , Widjaya Hannes
Published: August 2021

The very high growth of smartphone users in Indonesia makes companies that issue smartphone products have to try to be the best among other smartphone companies. Currently, OPPO is in second place in the smartphone market share in Indonesia in the second quarter of 2019. The aim of this study is to determine brand association, brand loyalty, brand awareness and brand image have an influence on brand equity. The sampling technique was carried out by purposive sampling. The questionnaire was distributed to 150 respondents in Karawaci Tangerang who were OPPO smartphone users. The results of this study indicate that there is an effect of brand association on brand equity, meanwhile, brand loyalty, brand awareness, and brand image have no influence on brand equity.
PENGARUH KUALITAS PELAYANAN DAN HARGA TERHADAP KEPUTUSAN PEMBELIAN PADA KEDAI KIRANI COFFEE
Authors: MUKTI ABDUL , Aprianti Kartin
Published: August 2021

Penelitian ini memliki tujuan untuk a)mengetahui ada tidaknya pengaruh kualitas pelayanan terhadap keputusan pembelian pada Kedai Kirani Coffe, b) mengetahui ada tidaknya pengaruh harga terhadap keputusan pembelian pada Kedai Kirani Coffe, c) mengetahui ada tidaknya pengaruh kualitas pelayanan dan harga terhadap keputusan pembelian pada Kedai Kirani Coffe. Penelitian ini merupakan penelitian asosiatif yang bertujuan untuk mengetahui pengaruh kualitas pelayanan dan harga secara parsial dan simultan terhadap Keputusan Pembelian pada Kedai Kirani Coffe. Populasi dalam penelitian ini adalah seluruh konsumen yang pernah berkunjung di Kedai Kirana Coffe. Menurut Aminulah (2013), menyetakan bahwa jumlah sampel  pada penelitian asosiatif sebanyak 50 orang. Sehingga dalam penelitian ini sampel sebanyak 50 responden. Teknik sampling yang digunakan oleh peneliti dalam penelitian ini adalah pengambilan teknik sampling purposive sampling. Purposive sampling adalah teknik penentuan sampel dengan pertimbangan tertentu, dalam penelitian ini yaitu konsumen yang pernah berkunjung di di Kedai Kirana Coffe. Hasil penelitian menunjukkan bahwa a) Kualitas Pelayanan Berpengaruh Positif dan Signifikan Terhadap Keputasan Pembelian pada Kedai Kirani Coffe, b) harga Berpengaruh Positif dan Signifikan Terhadap Keputusan Pembelian pada Kedai Kirani Coffe, c) Kualitas Pelayanan dan harga secara simultan Berpengaruh Positif dan Signifikan Terhadap Keputasan Pembelian pada Kedai Kirani Coffe.
ANALISIS PENGARUH GAYA KEPEMIMPINAN DAN LINGKUNGAN KERJA TERHADAP SEMANGAT KERJA PEGAWAI PADA DINAS LINGKUNGAN HIDUP (DLH) KOTA BIMA
Authors: Izzi Sirul , Yusuf Muhammad
Published: August 2021

Penelitian ini bertujuan untuk  mengetahui Gaya kepemimpinan dan Lingkungan Kerja terhadap Semangat KerjaPegawai pada Dinas Lingkungan Hidup (DLH) Kota Bima). Penelitian ini dilakukan pada Kantor Dinas Linglungan Hidup (DLH) Kota Bima. Penelitian ini di lakukan dengan menggunakan jenis penelitian asosiatif. Populasi yang di gunakan dalam penelitian ini pegawai Kantor Dinas Linglungan Hidup (DLH) Kota Bima sejumlah 137 pegawai. Dengan sampel penelitian 100 Aparatul Sipil Negara, dengan tekhnik pengambilan sampel menggunakan teknik purposive sampling. Teknik pengumpulan data yang di gunakan , 1,observasi, 2 dokumentasi, 3, kuisoner 4, studi pustaka. Teknik analisa data yang di gunakan, , uji validitas, uji realibilitas, uji asumsi klasik, uji normalitas, uji multikolineritas, uji Heteroskedastisitas, Uji koofesien korelasi, Uji koofesien Determinasi, Uji Analisis regresi Berganda, uji hipotesi (Uji t dan Uji F). Hasil penelitian ini menunjukah bahwa Gaya kepemimpinan dan lingkungan kerja bersamaan berpengaruh secara silmutan dan signifikan terhadap semangat kerja pegawai pada kantor Dinas Lingkungan Hidup (DLH) Kota Bima.
Exploring Drug and Antibody-Based Treatment Options for Creutzfeldt-Jakob Disease
Authors: Senthilraja Vasanth , Lou Eric , Nakka Abirath , Karamian Preny , Aslam Ishaq , Rabara Joel , Gahoonia Nimrit , Kaur Noor , Reddy Akshay , Ber The , Wagh Himanshu
Published: August 2021

Creutzfeldt-Jakob Disease (CJD) is a neurodegenerative disease characterized by mutant PrP prion proteins, which accumulates and impairs the function of wild-type PrPc proteins. The interaction of prion proteins with wild-type proteins converts the PrPc proteins to mutant PrP proteins. These mutant prion proteins lead to neural tissue degradation and other nervous system problems that can eventually lead to death. The use of antibodies to target and destroy prion proteins can be used to decrease PrP levels that can stop CJD progression. The binding affinities of different anti-PrP Fab antibodies are analyzed to determine which antibody best binds to PrP proteins and targets them for destruction. Through antibody-based targeting of prion proteins, potential treatment methods could be developed for CJD. In addition, the use of drugs, such as quinacrine and doxycycline, also show short-term effects in decreasing the progression of CJD. These drugs extend the average lifespan of tested subjects with CJD but also lead to the development of drug-resistant prion proteins that eventually cause the death of the subject affected by CJD.
Kajian Historiografis Pada Novel “Hulubalang Raja” Karya Nur Sutan Iskandar
Authors: Despy Nadia Peggy
Published: August 2021

He writing of the historical novel, Nur Sutan Iskandar, uses the thematic method to reveal Minangkabau Indigenous and Natural problems in various situations. In addition, Nur Sutan Iskandar also seemed not to take sides with any camp, both to the Kingdom of Inderapura, the Sultanate of Aceh and the Netherlands. From a leadership perspective, it is clear that Nur Sutan Iskandar's writings tend to refer to the Minangkabau people's Customs and Natural Traditions, namely public relations in historical writing. Research also shows that Nur Sutan Iskandar also tends to discuss the historical conflict between the Inderapura kingdom and the Aceh Darussalam kingdom. In fact, Nur Sutan Iskandar also discussed Balanda's intervention. This proves that Nur Sutan Iskandar has contributed to Indonesian historiography, even though Nur Sutan Iskandara's works are subjective because they are written in literary form.
Optimalisasi laboratorium komputer sebagai center of statistical development di Fakultas Ekonomi dan Bisnis Islam IAIN Salatiga
Authors: Rofiuddin Mohammad
Published: August 2021

The not yet optimal computer laboratory as a center of statistical development can affect the competencies possessed by students or lecturers in education, research, and community service. So, it is necessary to optimize the computer laboratory as a center of statistical development following the needs of the academic community and industry. Efforts include computer laboratory governance, installing the latest statistical/econometric software in computer laboratories, socialization of computer laboratory usage rules, simulation of data exploration using STATA, Eviews, Shazam software. As a result, these activities have been carried out well, although the authors still find some obstacles, and students can attend training and learn statistical or econometric software needed to support the teaching and learning process.
後疫情時代公共治理及社經發展
Authors: 江明修 江明修 , 黃東益 黃東益 , 黃明聖 黃明聖 , 黃東益 黃東益 , 蘇建榮 蘇建榮 , 劉梅君 劉梅君 , Mei-Chun Liu 鄭麗君 , 陳敦源 陳敦源 , Don-Yun Chen 黃天牧
Published: August 2021

基於社會關懷，善盡大學責任，政大行政管理碩士學程（MEPA）規劃「後疫情時代公共治理及社經發展研討會」多時，最後決定於2021年6月5日舉辦。但是2021年5月中旬適逢疫情再起，三級警戒，研討會於是改採線上視訊辦理。「後疫情時代 公共治理及社經發展研討會」聚焦在財經議題、社會發展及公共政策形成三大面向，結合實務與學術，期待透過公民社會的力量為臺灣社會找到出路。財經與社會，此二者屬於內外環境的衝擊，公共政策則是行政主體。新冠疫情的確是很不幸的考驗，可是疫情卻也給我們一個反思的機會。在抗疫期間，大家可以看到民間社會動員的力量，我們正是希望結合公民行動的力量，共同來因應全球化及疫情之下所遭遇到的問題。
Produção de farelo de gliricídia para alimentação de ruminantes
Authors: Silva Haroldo Wilson , Santos Arleto Tenório , Perego Pierro Eduardo , Godinho Angela Madalena Marchizelli
Published: August 2021

O uso de leguminosas forrageiras como fonte de nutrientes tem resultado em aumentos de produção animal, decorrentes do incremento nos níveis proteicos. Entre as leguminosas com potencial forrageiro, está a gliricídia, devido as suas características bromatológicas, quando se considera seu elevado teor de proteína bruta em suas folhas. Objetivou-se avaliar a produção de farelo de gliricídia como fonte de suplementação proteica na alimentação animal. O projeto foi conduzido na Faculdade de Tecnologia de São Paulo (FATEC) no município de Presidente Prudente – SP. O plantio foi realizado em abril de 2020 em espaçamento de 1,0 m entre linhas x 0,5 m entre plantas e estande com 120 plantas com área experimental de 70 m2de área total. O experimento teve início com o corte da Gliricídia que ocorreu no mês de abril de 2021, quando a planta atingiu 1,5 m, cortando-se toda parte aérea a partir de uma altura de 0,5 m do solo, com cerca de um ano de idade. O farelo de gliricídia foi processado a partir das folhas e caule tenros das plantas com desidratação ao ar livre, sobre lona de polietileno com duração média de 5 dias e logo em seguida foi realizada a moagem. Conclui que a Gliricídia demonstrou que é uma leguminosa eficaz na produção de biomassa verde do ponto de vista econômico para produção de farelo.
Normativa, agenda digital y política de transformación digital: hacia un gobierno digital peruano
Authors: Laurente Itala
Published: August 2021

El motivo para elaborar este artículo es debido a que, en el Perú, la normativa y las políticas en gobierno digital y transformación digital se encuentran en proceso de desarrollo, por lo que resulta necesario realizar un mapeo de las leyes y la política nacional. Se escogió Perú porque es un país que, si bien tiene normativa, se encuentra en proceso de elaboración de la agenda digital y la política nacional de transformación digital. La pregunta de investigación es ¿de qué manera se han desarrollado la normativa y las políticas vinculadas al gobierno digital en Perú – 2020? El objetivo de la investigación es establecer un análisis descriptivo de la normativa, agenda digital, así como la política de transformación digital en el Perú. Considerándose para los objetivos específicos: a) describir el contenido de la normativa vinculada con el gobierno digital en el Perú, b) describir la agenda digital c) explorar la etapa de diseño y formulación de la política de transformación digital. El diseño metodológico es cualitativo, para la data documental se realizó una revisión documental a las normas, agenda digital y la política nacional de transformación digital las que se encuentran en la etapa de diseño y formulación. Para la data cualitativa, se elaboró un cuestionario para a un experto con conocimiento en transformación digital o participante del proceso de elaboración de la política. Concluyéndose que, existió modificaciones en la normativa, desde el gobierno electrónico hacia el desarrollado de un gobierno digital, según las recomendaciones de la Organización para la Cooperación y el Desarrollo Económico; esta base normativa es el soporte para la creación de instituciones, planes, agendas, estrategias, entre otras, sobre gobierno digital peruano; tanto la Agenda Digital del Bicentenario como la Política Nacional de Transformación Digital se encuentran en proceso de elaboración, utilizándose estrategias metodologías como una encuesta nacional, mesas de codiseño, y entrevistas a profundidad, que permitirán obtener información precisa y experimentada para conseguir mapear la necesidad y desafíos del gobierno digital en Perú. Aún existe la idea que la transformación digital proviene del ámbito privado, debiendo ser un tema que configure un trabajo conjunto entre diferentes sectores con el Estado.