bluuebunny/crossref_metadata_2025 huggingface dataset:
Hadis Iftirāq dalam Literatur Otoritatif: Potret Jaringan dan Kepentingan
Authors: Miski Miski
Published: December 2022

Iftirāq hadith creates its own problems. The hadith is used as a tool that triggers internal religious conflicts, truth claims, and stereotypes, and so on. Moreover, the hadith is also found in Sunan Abū Dāwūd, Sunan al-Tirmiżī, and Sunan Ibn Mājah; three authoritative sunan in hadith scholarship. It is important to look at this from the most basic aspect, namely how sources of transmission, networks, and socio-political-cultural contexts surround the existence of the iftirāq hadith. This study uses the three Sunan as primary data; in tracing the related hadiths, this study uses the takhrīj method; supported by other relevant data; all of these data were analyzed by descriptive and socio-historical methods. This study also has three main findings. First, the iftirāq hadith networks in the three Sunans tend to be diverse, although one of the three networks is correlated with the same narrator, namely, Abū Hurairah. Second, the source of iftirāq hadith transmission cannot be separated from the riḥlah tradition that existed at that time; this allowed all three to meet the narrators of the hadith. Third, the existence of the iftirāq hadith cannot be separated from the context at that time which tended to be conflicted; from the interests of confirming identity to the struggle for authority between religious groups.
Dinamika Relasi Nabi SAW dengan Yahudi Perspektif Teori Konflik Ralf Dahrendorf
Authors: A'yun Qurrota , Zulfikri Zulfikri , Hakim Luqmanul
Published: December 2022

This article aims to find out the form of connection that occurred between the Prophet Muhammad and the Jews in Madina. The population of Madina consists of a wide variety of tribes, religions, and social and economic levels. In this situation, it is perilous for conflict to occur. It is known that there were three popular Jewish groups in Madina, namely the Banu Qainuqā, the Banu Naḍīr, and the Banu Qurayẓah. In addition, the author wants to explore the factors that influence the dynamics of the connection between the Prophet Muhammad SAW and the Jews. In order to find out the answer to the question, this research was conducted using qualitative methods from the perspective of Ralf Dahrendorf's conflict theory. The results of this study were: First, the relations started when the Prophet Muhammad SAW moved to Madina and the involvement of the Jews in a mutual agreement. Furthermore, the axis of the conflict began to appear when there was a debate on the issue of faith and worship. Second, the factors that influenced the relations of the Prophet Muhammad SAW in the perspective of conflict theory were three factor; the factor of the seizure of authority, the ethnocentrism factor and transferred culture factor.
Kontekstualisasi Surah al-Nūr Ayat 11-20 Pada Open Journal System Indonesia Kontemporer
Authors: Itrayuni Itrayuni , Ashadi Andri , Faizin Faizin
Published: December 2022

Several authors of journal articles discuss Surah al-Nūr verses 11-20 related to the ifki hadith. The author considers that some of these articles are strongly influenced by Abdullah Saeed's theory because there are aspects of the Qur'an's linguistic and historical context, both micro and macro, as well as contemporary contexts. In this theory there is the story of 'Aisyah r.a. that was slandered at the time of the Prophet known as the ifki hadith which was later enshrined in Surah al-Nūr verses 11-20. The purpose of this study is to elaborate on the extent to which the authors of the article contextualize surah al-Nūr verses 11-20. The method used in this research is a qualitative method with library research. The theory used in this study is Abdullah Saeed's theory with a contextual approach. The findings of this study are that in general, the articles that study Surah al-Nūr verses 11-20 have fulfilled the theory put forward by Abdullah Saeed. One of the articles that fulfill Abdullah Saeed's contextual interpretation is the article written by 'Ayun Masfufah that this article takes the past context and then relates it to the current context.
The production of urban space in the contemporary city and its resulting urban phenomena
Authors: Bezerra Pamela Fernanda Rodrigues , Moraes Lúcia Maria
Published: December 2022

The article aims to discuss the production and reproduction of urban space, demonstrating how these socio-spatial dynamics occur and that urban phenomena can occur on consolidated land. Contemporary medium-sized cities undergo growing urbanization and among these occurrences generate segregation, a spreading out, gentrification and witness both land and real estate speculation. Most of these occur as a function of capital or with some kind of intervention by it. It seeks to demonstrate how the production of urban space takes place and which agents are involved in it, in addition to looking at what the relationship between them is: namely capitalist social relations and relations of production. Urban land is a product considered a commodity, and this is the object of a struggle between social classes for access to land. Urban space, considered central and endowed with infrastructure, is, in most cases, appropriated by those who have the greatest amount of capital, leaving the lower social strata with less purchasing power to purchase in peripheral areas often with little or no infrastructure. The methodology used was exploratory with a qualitative approach, with reference to authors with scientific mastery of the subject.
Evaluation of tensile adhesion strength in mortar for coating with incorporation of crushing sand
Authors: Erba Leandro Augusto , Azambuja Maximiliano dos Anjos
Published: December 2022

The use of crushed sand, a by-product generated in quarries during the process of manufacturing crushed stone used in civil construction, can reduce the consumption of natural sand, reducing the environmental impact of the extraction of this material. In this sense, this research aims to evaluate the influence of replacing natural sand with crushed sand on the tensile bond strength of mortars. Mortars were made with crushed sand from quarries in the region of Bauru/SP, performing 3 percentages of substitution, in mass, of natural sand by crushed sand: 10%, 20% and 30%, plus a reference with 100% sand natural, totaling 4 strokes. All mortars were made in accordance with ABNT NBR 13276/2005. The performance of the mortars was evaluated through the tensile bond strength test, as recommended by the ABNT NBR 13528/2019 standard. In the end, it can be said that it is feasible to use crushed sand to replace natural sand in the percentage of up to 20% for making mortars for coating external walls, which showed the best adhesion results. It was also found that, for internal coating, it is possible to use up to 30% of crushed sand, without compromising the performance of the mortar.
Proposal of a methodological sequence for the spatial-temporal analysis of real estate developments: Application in Natal/RN
Authors: Neto Flaviano Ferreira dos Santos , Queiroz Luiz Alessandro Pinheiro da Câmara de
Published: December 2022

This article aims to analyze the spatial distribution of real estate projects, launched during the 10 most intense years of the real estate market in the city of Natal/RN. However, the lack of data on the real estate production of several national capitals, based on the absence of clear procedures for capturing and organizing this type of information, represents a limiting factor for the development of an analysis of this nature. To circumvent this limitation, this study proposed a methodological sequence capable of capturing, systematizing and georeferencing a wide variety of data referring to real estate developments in any Brazilian city. The application of this new methodological itinerary in the capital of Rio Grande do Norte reveals an asymmetrical spatial distribution in the municipal territory, considering that 86% of real estate developments are concentrated in 4 areas, which correspond to only 19% of the territorial extension of the municipality in question. In 3 of these 4 locations there is a tangible connection between the type of real estate production and some physical and socioeconomic characteristics found in them, such as tourism, environment, urban facilities, in addition to the purchasing power of the population. Finally, the role of the State was identified as an inducer of real estate development in a peripheral region through a housing program promoted by the Federal Government.
Smart mobility and sustainability: a bibliometric analysis
Authors: Borchers Tatiane , Figueirôa-Ferreira Victor Garcia , Fernandes Ricardo Augusto Souza
Published: December 2022

At the end of the 1980s, sustainability became a focus of attention worldwide. More recently, with the consolidation of researches and implementations of smart cities, characteristics that permeate this concept were also studied in greater depth, in terms of smart mobility and smart environment. This study seeks to make a bibliometric analysis on smart mobility and sustainability. The results found show that the researches in this area are recent, with less than a decade of publication, in which Europe concentrates the largest percentage of participation in number of publications and citations, and the main subject addressed in the most cited works is the questioning of the connection between smart cities, smart mobility and sustainability. The map of keywords presents research gaps, which represent opportunities of scientific contribution for future studies.
Morphological analysis and clinical significance of the opening of the third coronary artery
Authors: Lujinović Almira , Dervišević Lejla , Ćosović Esad , Ajanović Zurifa , Kapić Dina , Pepić Esad
Published: December 2022

Introduction: The human heart is in most cases vascularized by two coronary arteries, the right coronary artery (RCA) and the left coronary artery. The supernumerary coronary artery, which arises independently from the right aortic sinus and passes through sub-epicardial adipose tissue of the pulmonary conus and anterior side of the right ventricle is called the third coronary artery (TCA).
Methods: This study consisted of 28 formalin-fixed adult human cadaveric hearts. The presence of the TCA was determined. The position of the orifice of the right and excess arteries in relation to the sinotubular junction was determined, and then also the position of the orifice of the excess arteries “on the o’clock level” in relation to the orifice of the RCA. The radius of these orifices and their distance from the orifice of the RCA were measured. The angle between the aorta and TCA, as well as RCA and conus branch, was measured.
Results: A total 11 of specimens had supernumerary arteries. A supernumerary artery was found in two hearts. The angle formed by the aorta with the TCA was 60.09 ± 17.57, while the angle between the aorta and the conus branch had an average value of 89.88 ± 15.92. The orifices of all supernumerary arteries were located below the level of the sinotubular junction. The average diameter of the TCA was 1.49 mm ± 0.41. The average distance between the TCA orifice and the RCA orifice was 2.21 mm ± 1.03. In 45.45% cases, the orifice of TCA was located at the 10 o’clock level.
Conclusion: The present study highlights the presence of the TCA. It may constitute a significant collateral circulation contributing to apical and septal perfusion. Interpretation of signs and symptoms of coronary occlusion should therefore include possible contribution of this vascular channel.
Additions and changes to the Red Books of the Russian Federation and Primorsky Krai: ferns
Authors:   Botanical Garden-Institute FEB RAS, Khrapko Olga V.
Published: December 2022

Based on the analysis of the distribution and characteristics of rare representatives of the Far Eastern pteridophlora, it is proposed to include 8 species of ferns in the new edition of the Red Data Book of the Russian Federation, and to change the category of three species listed in the Red Data Book of Primorsky Krai.
Introduction resource of the genus Astilbe representatives in the south of Primorsky Krai
Authors:   Botanical Garden-Institute FEB RAS, Shelekhova Olga M.
Published: December 2022

The collection of the genus Astilbe of the BGI FEB RAS is represented by 3 species and 136 varieties from 9 garden groups. Under monsoon climate conditions, varieties and species go through all phenological phases successfully. The flowering lasts from late June until mid-September. The pollen viability of varieties and species varies from 0 to 69%. It was found that the viability of A. chinensis pollen is affected by temperature and storage duration. The ability for vegetative propagation of 71 varieties and 2 species was studied. Under the conditions of the BGI FEB RAS, the coefficient of vegetative propagation was 11.3. Recommendations for Astilbe varieties affected by diseases and pests are given.
Talinum paniculatum (Talinaceae) – a new species of alien flora for the Russian Federation
Authors:   Botanical Garden-Institute FEB RAS, Nesterova Svetlana V. , Marchuk Elena A. ,   Botanical Garden-Institute FEB RAS
Published: December 2022

About first finding of the alien species Talinum paniculatum in the collection of open ground plants and in the greenhouses of the Botanical Garden-Institute FEB RAS is reported. The species is considered a pantropical weed. It is found in many countries of the world as an adventive plant. This is the first mention of T. paniculatum for the territory of the Russian Federation.
A perspective hybrid Magnolia × loebneri in the south of the Russian Far East: possibility of using in ornamental gardening of the region
Authors:   Botanical Garden-Institute FEB RAS, Kameneva Lyubov A. , Bogachev Ilya G. ,   Botanical Garden-Institute FEB RAS
Published: December 2022

The report presents some results of Magnolia × loebneri cultivation in the Botanical GardenInstitute FEB RAS (Vladivostok). In the climatic conditions of southern Far East of Russia, M. × loebneri showed significant winter hardiness and stable abundant flowering, exceeding the characteristics of parental species (Magnolia kobus × Magnolia stellata), as well as high resistance to diseases and pests. In this regard, it seems very promising to include M. × loebneri in the assortment of ornamental woody plants, used in landscaping and develop its introduction tests in Primorsky Krai.
Ensaios clínicos randomizados: porque precisamos nos apropriar deste método?
Authors: Rabelo-Silva Eneida Rejane , Mantovani Vanessa Monteiro , Saffi Marco Aurélio Lumertz
Published: December 2022

Ensaios clínicos randomizados (ECRs) são estudos destinados a avaliar a eficácia de uma intervenção terapêutica ou profilática sobre um determinado desfecho. O ECR é considerado o padrão ouro para se testar os efeitos de um tratamento farmacológico, de uma ação educativa, de um exercício, de um cuidado, de um comportamento ou estilo de vida. Os efeitos testados podem incluir redução da taxa de mortalidade, morbidade, alívio de sintomas clínicos, melhora da qualidade de vida, melhora de capacidade funcional, ganho de conhecimento, mudança de comportamento, efeito em cicatrização, redução de parâmetros como peso, pressão arterial, perfil lipídico, glicemia, entre tantos outros desfechos que importam aos pacientes, aos indivíduos e à comunidade.
Conhecimento dos estudantes de enfermagem sobre biossegurança no contexto hospitalar na pandemia: abordagem qualitativa
Authors: Silveira Sthéfany Suzana Dantas da , Silva Raphaela Moreira Gomes da , Silva Mariana Tavares da , Teixeira Raquel Cardoso , Goulart Maithê de Carvalho e Lemos , Góes Fernanda Garcia Bezerra , Ávila Fernanda Maria Vieira Pereira , Fernandes Ana Paula da Fonseca da Costa
Published: December 2022

Objetivo: Descrever o conhecimento dos estudantes de enfermagem sobre as medidas de biossegurança no contexto hospitalar em tempos de pandemia. Método: Estudo descritivo, exploratório, qualitativo, com estudantes de enfermagem de uma universidade pública da baixada litorânea do Rio de Janeiro, Brasil, através de entrevista em ambiente virtual, entre julho e setembro de 2021. Utilizou-se o Interface de R pour Analyses Multidimensionnelles de Textes Et de Questionnaires para processamento do corpus textual e Análise de Conteúdo Temática para interpretação das falas. Resultados: Participaram 29 estudantes que reconhecem a biossegurança, mas não possuem segurança ao abordá-la. Para eles, trata-se de normas para proteção do trabalhador e pacientes, associando-as aos EPIs e ao uso durante a pandemia. Conclusão: A biossegurança não é reconhecida na sua totalidade entre estudantes de enfermagem que estarão no mercado de trabalho futuramente. É necessário um olhar ampliado em perspectiva transversal, especialmente nas disciplinas do ciclo profissionalizante da enfermagem.
Comparative assessment of results of D2 and D3 lymph node dissections in term of colon cancer surgery
Authors: Kit O. I. , Dzhenkova E. A. , Mirzoyan E. A. , Gevorkyan Yu. A. , Kolesnikov E. N. , Snezhko A. V.
Published: December 2022

Purpose of the study. Was to evaluate overall survival of CC patients after D2 and D3 lymph node dissections and assess the frequency of postoperative complications and dynamics of postoperative recovery.

Materials and methods. The study included 50 CC patients aged 39–84 years.

Results.  The comparative assessment of the overall survival, frequency of postoperative complications and dynamics of postoperative recovery was performed in patients divided into 2 groups depending on the lymph node dissection extent. Group 1 included 23 patients (46 %) with D2 lymph node dissection, group 2–27 patients (54 %) with D3 lymph node dissection. 8 (16 %) patients developed complications in the early postoperative period. Patients in group 1 had grade I (5 patients) and grade IIIb (1 patient) surgical complications, according to the Clavien-Dindo classification. 2 patients in group 2 developed grade III b complications. No significant differences were found between groups in peristalsis, gases and bowel movement, starting eating and drinking. A significant increase in the number of postoperative bed-days was observed in patients who underwent open surgery, compared with the group with laparoscopic access. No statistically significant difference was found in the overall survival in patients of the two groups (p = 0.918).

Conclusion. The rates of postoperative complications that required repeated surgery were comparable between the groups with D2 and D3 lymph node dissections. D3 lymph node dissection did not affect the dynamics of postoperative recovery and the overall survival of patients.
Successful throb endarterectomy in a patient with occlusion of the internal carotid artery
Authors: Akhmetov V. V. , Mozharovskiy K. V. , Gapizov M. S. , Shilov R. V. , Chernikova Yu. V. , Dudanov I. P.
Published: December 2022

Strokes account for 15–25 % of confirmed cases internal carotid artery (ICA) occlusion. The frequency of ICA occlusion in asymptomatic patients is unknown. The strategy of treatment patients with symptomatic ICA occlusion has not been determined. A clinical observation is presented with the stage of surgical treatment of a 67‑year-old patient with a developed stroke in the basin of the left middle cerebral artery. The examination according to MSCT angiography revealed occlusion of the left ICA. To assess the brain perfusion, a single-photon emission computed tomography (SPECT) with 99mTc was performed. Throb endarterectomy of the left internal carotid artery was performed, with a control ultrasound examination on the 6th day after the operation and after 6 months the blood flow through the internal carotid artery was preserved. Control SPECT with 99mTc was performed, in comparison with the previous study, a significant improvement perfusion on both hemispheres is determined. Improvements in the neurological status were noted in the form of a complete regression of neurological symptoms. On the sixth day after surgical treatment, the patient was discharged in a satisfactory condition. During the hospital stay, the patient was “examined” using a questionnaire for assessing the quality of life – The Short Form‑36 (SF‑36) and MoCA (Montreal Cognitive Impairment Assessment Scale). The survey was conducted on the 15th day of inpatient treatment, before surgery, and on the 6th day after surgery. After 6 months, the patient was re-interviewed. The results obtained indicate a correlation between the improvement of brain perfusion and cognitive impairment, as well as a positive effect of revascularization of the internal carotid artery on the patient’s quality of life. The presented results indicate not only the possibility, but also the high efficiency of surgical treatment of occlusive lesions of the internal carotid artery. Surgical treatment in the early stages after occlusion against the background of the collapse of atherosclerotic plaque and thrombosis of the lumen is a determining factor in the successful restoration of blood flow, improvement of brain perfusion.
Repeated irreversible electroporation in a locally advanced pancreatic cancer
Authors: Polyakov A. N. , Podluzhnyi D. V. , Kudashkin N. E. , Bazin I. S. , Medvedeva B. M. , Syskova A. Yu. , Kantieva D. M. , Patyutko Yu. I.
Published: December 2022

It is reasonable to consider the technical possibility and oncological feasibility of the local tumor destruction in patients with locally advanced pancreatic cancer (PCa). Irreversible electroporation (IRE) is a non-thermal method of local tumor ablation, which uses non-thermal energy of high-voltage ultrashort electric fields localized between electrodes to create nanopores in the cellular wall with the following cellular death. The zone of impact can be accurately predicted using the location of the electrodes. A fairly clear and controlled ablation boundary without a clinically significant zone of perifocal tissue damage reduces the risk of accidental injury to the wall of a hollow organ. The method is based on a change in the permeability of the cell membrane and the development of apoptosis, which allows to act directly on the ducts and the great vessels infiltrated by the tumor without a high risk of damage. The presented case shows that IRE is advisable to use as a part of the combined treatment of patients with locally advanced PCa. There were no complications observed after the IRE. Radiological evaluations and pathologic reports showed an adequate long-term local control. Also, good results were obtained in the overall life expectancy, given that we are talking about unresectable ductal adenocarcinoma of the pancreas. The patient passed away in 39 months from the beginning of the treatment and in 26 months from the initial IRE. In case of local relapse, repeated electroporation with a good long-term result is also possible. The time to progression exceeded eleven months after electroporation performed for a local relapse. According to magnetic resonance imaging, both locoregional relapse and distant liver metastases were detected. The patient lived 16 months after a repeated IRE session and died of pulmonary embolism on the background of chemotherapy. Favorable prognostic factors are the presence of an objective response to previous conservative treatment, compliance with the parameters of electroporation, complete inclusion of tumor infiltration in the affected area.
Male infertility along with the era of coronavirus infection SARS-CoV-2
Authors: Kulchenko N. G. , Druzhinina N. K. , Myandina G. I.
Published: December 2022

Russian and foreign epidemiological data suggest that males may have an increased risk of morbidity and mortality associated with COVID‑19. It is known that due to the high expression of ACE2 in spermatogonia, Leydig and Sertoli cells, the testicle, as an organ producing male germ cells, is a potential target for the COVID‑19 virus, which directly affects the reproductive health of men. To date, several factors of the influence of the SARS-CoV‑2 virus on the male reproductive system are known. To begin with, when infected, the virus has a direct damaging effect on the testicle itself with the provocation of orchitis. In addition to the previous statement, high body temperature during inflammation contributes to an increase in testicular temperature, which can lead to a deterioration in the quality of sperm. Furthermore, a pronounced inflammatory reaction promotes the circulation of a large number of cytokines and damage to the hemato-testicular barrier. Also, the increased activity of immunocytes leads to an imbalance of the antioxidant system of men, an increase in the level of reactive oxygen species and the formation of oxidative stress. In a Nutshell, Leydig cell dystrophy provokes the development of secondary hypogonadism. Thus, COVID‑19, like a “multifaceted Janus”, has a polysymptomatic manifestation, but at the same time has a multifactorial effect on the reproductive function of a man. All these factors of the impact of the SARS-CoV‑2 virus on the testicle must be considered when rehabilitating the patient. It should be kept in mind that the deterioration of sperm quality is observed both during the acute period of coronavirus infection and during recovery period. Therefore, laboratory evaluation of the ejaculate in dynamics and its correction is necessary for males, especially those who plan to realize their reproductive potential.

Conclusion. COVID‑19 generally has a negative impact on spermatogenesis and male fertility. To date, the timing and degree of restoration of a man’s reproductive function after a coronavirus infection remains completely unknown. Therefore, both in the early and late rehabilitation period, men of reproductive age need the supervision of an andrologist.
Global burden of colorectal cancer: epidemiology, risk factors
Authors: Medvedeva E. A. , Maryin G. G. , Leshchenko A. A. , Chernogorova M. V. , Dolgova M. B. , Nazarov D. A. , Ivanov S. A.
Published: December 2022

A few decades ago, colorectal cancer (CRC) was diagnosed much less frequently. It is currently the fourth and in some countries the third most lethal cancer in the world, with about one million deaths each year. Most colon tumors develop as a result of a multistep process involving a number of histological, morphological and genetic changes, the frequency of detection of which increases with the age of the patient. Timely screening aimed at identifying and removing precancerous neoplasms in the early stages can lead to a significant reduction in the incidence of CRC. Despite this, the currently diagnosed rate of CRC in everyday clinical practice is relatively low, however, it is predicted that with personalized, based on anamnesis, screening for CRC, the frequency of its detection will increase significantly. The practitioner needs to be aware of the risk factors leading to CRC and the various stages of disease progression in order to recommend appropriate screening strategies. The use of a surveys that includes risk factors in the collection of anamnesis will reduce economic costs and not miss a cohort of patients who need a detailed examination. The purpose of the review is to present current data on the epidemiology of CRC and risk factors contributing to the occurrence of CRC. A literature review of articles (original studies and reviews) published between 2016 and February 2022 on the study of risk factors for CRC was performed. The methods of bibliographic, informational and semantic search of sources in the databases of Google PubMed, Scopus were used. The article discusses in detail the epidemiology and highlights the modified and non-modified risk factors for CRC, including within different age categories. Data on early CRC in young people are presented in detail and carry clinical and molecular features, as well as the role of the hereditary factor in development.
Staff policy issues in scientific research
Authors: Armashevskaya O. V. , Menshikovа L. I.
Published: December 2022

Purpose of the study. Analysis of implemented personnel practices presented in dissertations in the specialty 14.02.03. Public health and healthcare for 2016–2020.

Materials and methods. We used data from the website of the Higher Attestation Commission under the Ministry of Science and Higher Education of the Russian Federation. Of the 220 dissertations, the authors of which were awarded the degree of candidate or doctor of medical sciences in the specialty 14.02.03 Public health and health care, 21 scientific papers devoted to personnel issues were singled out. In this study, a descriptive-analytical method was applied.

Results. Dissertations covering a fifteen-year period since the beginning of the modernization of healthcare revealed a number of problems: low wages; insufficient staffing, disproportion between doctors and paramedical workers; difficult working conditions, the outflow of personnel from the industry in general, as well as from public health institutions to private medical organizations. Approbation of developments and implementation on the basis of research, evaluation of their effectiveness allowed the authors to offer recommendations for implementation in healthcare practice, starting with the Ministry of Health of the Russian Federation, government bodies of the subject of the Federation, a medical organization, educational institutions and ending directly with the object of study – management personnel, doctors, secondary medical worker. The study and analysis of personnel practices presented in scientific research makes it possible to determine the most relevant areas for the formation of personnel policy.

Conclusion. The results of the study showed a small number of dissertations (9.5 %) devoted to personnel issues and defended in the specialty 14.02.03. Public health and healthcare, despite the decisive role of human resources in the innovative development of the country’s healthcare. The studies covered all groups of medical workers, managers, students of medical universities, colleges and included the study of the state of health, motivation, job satisfaction, leadership training, interaction between medical workers of different levels and patients. Effective practices are proposed that can be replicated at the regional level, new ones can be created on their basis, and they also make it possible to determine the criteria for assessing staff policy in a medical organization, subject and country.
A comparative study of different contrast administration routes efficiency performed on in vivo colorectal cancer models
Authors: Goncharova A. S. , Khodakova D. V. , Galina A. V. , Zaikina A. V. , Kurbanova L. Z. , Mindar M. V. , Gurova S. V.
Published: December 2022

Purpose of the study. The investigation is aimed to provide a systematic comparison of different contrasting methods for in vivo micro-CT diagnostic of orthotopic colorectal cancer models extracted by ortotopic implantation into the caecum of immunocompromised mice BALB/c Nude lines.

Materials and methods. BALB/c Nude (N = 25) female mice were implanted by transplanted human colorectal cancer strain into the cecum. 20 days after the implantation mice were administered with iodine-based contrast agent Optiray by means of different administration method (intravenously, per os, intraperitoneally, per rectum) and micro-CT scans have been registered via Quantum GX2 tomograph. Measurement of tumor nodes was performed both by means of estimation from micro-CT images via RadiAnt DICOM Viewer software and by means of explicit measurements using calipers upon laparotomy and posthumously. At the last stage of the study, the animals were euthanized by cervical dislocation. The tumors were excised, measured with a caliper and placed in 10 % formalin for the standard histological analysis according to the standard methods.

Results. The average volumes of tumor xenografts in animals with intravenous, oral, and intraperitoneal contrast administration measured at micro-CT were 53.7 ± 5.2 mm3, 52.7 ± 6.4 mm3 and 63.6 ± 5.6 mm3 respectively; measured at laparotomy – 43.0 ± 5.5 mm3, 44.5 ± 5.4 mm3 and 58.5 ± 5.5 mm3 respectively; measured post-mortem – 55.2 ± 6.6 mm3, 53.2 ± 8.8 mm3 and 65.9 ± 3.8 mm3 respectively. The average volumes of tumor xenografts isolated post-mortem in these groups were comparable with the values shown at micro-CT, but larger than the volumes measured at laparotomy.

Conclusion. The results obtained demonstrated that intravenous, peroral and intraperitoneal administration techniques provide the best visualization of laboratory rodents pathological tissue upon in vivo micro-CT diagnostics and thus are preferred.
Role of hypothalamic-pituitary-adrenal axis and catecholamine factors in independent and primary multiple types of tumor growth
Authors: Frantsiyants E. M. , Bandovkina V. A. , Kaplieva I. V. , Surikova E. I. , Pogorelova Yu. A. , Cheryarina N. D. , Trepitaki L. K. , Neskubina I. V. , Vereskunova A. A. , Kotieva I. M. , Shumarin K. A. , Shikhlyarova A. I. , Goroshinskaya I. V.
Published: December 2022

Purpose of the study. To study the levels of adrenal axis factors in the hypothalamus, adrenal glands, blood serum of mice and catecholamines in the adrenal glands during the independent growth of B16 melanoma and Lewis lung carcinoma (LLC) and their combined growth in female mice, and in males – with independent growth of B16 and combined growth of B16 and LLC.

Materials and methods. Male and female BALB/c Nude mice were divided into groups, n = 7 each: group 1 involved intact animals, group 2 involved mice with B16/F10 melanoma, group 3 – mice with LLC, group 4 – synchronous growth of melanoma and LLC. Levels of corticotropin releasing, noradrenaline and dopamine were determined in homogenates of the hypothalamus and adrenal glands and in the blood serum of all animals by ELISA, and levels of 17‑hydroxyprogesterone (17-OHP), dehydroepiandrosterone sulfate (DHEA-S) and cortisol were determined by RIA. Statistical processing of results was performed using the Statistica 10.0 program.

Results. All tumor-bearing females showed elevated corticotropin releasing in the hypothalamus together with an increase of all stress-characterizing parameters: cortisol, the cortisol/DHEA-S ratio, and noradrenaline. However, an increase in serum levels of cortisol was blocked by high levels of DHEA-S, and as a result, the cortisol/DHEA-S ratio was either within the normal range (B16 melanoma and B16+LLC combination) or reduced (LLC). Levels of corticotropin releasing in the hypothalamus of tumor-bearing males decreased, together with opposite changes in stress-characterizing parameters in the adrenal glands: cortisol increased, the cortisol/DHEA-S ratio did not differ significantly from the control values, and noradrenaline decreased. An increase in serum levels of cortisol was not blocked by high levels of DHEA-S, and as a result, the cortisol/DHEA-S ratio was sharply elevated in B16 melanoma and B16+LLC combination.

Conclusion. At independent and primary multiple types of tumor growth, the sex-specific features of the functioning of the adrenal axis at the central and peripheral levels are observed, which determines a more pronounced stressful state of the body with B16+LLC combination growth, realized by various mechanisms.
Evaluation of Toll-like receptors expression in terms of colon cancer
Authors: Dzhenkova E. A. , Mirzoyan E. A. , Sagakyants A. B. , Bondarenko E. S. , Zlatnik E. Yu. , Shaposhnikov A. V. , Kolesnikov E. N. , Kaymakchi O. Yu. , Dashkov A. V. , Kaminskiy G. V. , Milakin A. G. , Malinin S. A. , Savchenko D. A. , Chalkhakhyan L. Kh.
Published: December 2022

Purpose of the study. To evaluate the number of cells with the CD45+/- phenotype expressing Toll-like receptors (TLRs) in tissues of the tumor, peritumoral area and resection line tissues in colon cancer (CC) with various tumor locations.

Materials and methods. The study included 50 patients with CC. All patients underwent surgery as the primary treatment, and tissue material was collected from the patients. Expression of TLRs (2, 3, 4, 8, 9) on CD45+, CD45- cell populations was determined by flow cytometry in cell suspensions obtained from tissues of the tumor, peritumoral area (1–3 cm from the tumor) and resection line tissues (~10 cm from the tumor) with further calculation of the percentage of cells with the corresponding phenotype from the total number of cells.

Results. An analysis of left-sided colon tumors showed lower percentage of CD45- cells expressing TLR4, 8, compared to rightsided tumors, by 38 % and 25 %. A comparative analysis of the number of CD45+ cells expressing TLR 2, 4 showed their decrease by 81 % and 87 %, respectively, compared with right-sided tumors. An assessment of the data in the perifocal zone of left-sided colon tumors, compared with right-sided ones, demonstrated a decrease in the percentage of cells with the CD45- phenotype that express TLR4, by 61 %. Resection line tissues in left-sided tumors, compared with right-sided ones, showed a statistically significant increase in the percentage of CD45- cells that express TLR 2, 4 by 205 % and 55 %, respectively. The number of CD45+ cells expressing TLR 4 decreased by 87 %. An assessment of the number of cells expressing TLRs 3 and 9 in the tumor, peritumoral area and resection line tissues did not reveal significant differences.

Conclusions. Lower number of cells with CD45+ and CD45- phenotypes express TLRs 2, 4, 8 in left-sided colon tumors and their peritumoral tissues, compared to right-sided cancer.
Zoning of the reaction of the tissues of the implantation area after prosthetic repair in abdominal hernias in experiment
Authors: Lukoyanychev E. E. , Izmailov S. G. , Evsyukov D. A. , Nikolskij V. O. , Mironov A. A. , Panyushkin A. V.
Published: December 2022

Purpose of the study. Development of criteria for evaluating the reaction of tissues in the implantation area after prosthetic repair of the hernia ring in an experiment using new digital image processing technologies.

Materials and methods. The experiment was carried out on 13 Wistar rats of different sexes. Under anesthesia, a 4 × 2 cm mesh prosthesis was implanted in the layer similar to the onlay epiaponeurotic. The preparation and staining of each preparation was carried out in two versions: with hematoxylin-eosin and according to Mallory on different glasses. The seasons for performing experiments are winter, summer. Microphotography was performed on a medical transmitted light microvisor Microvisor μVizo‑103 (AD LOMO, Russia) with a 3.2 Mpx matrix (full frame size 1024 × 882 px, infoband width 88 px) with Planachromat and Stigachromat lenses with a digital scale × 1 (i.e. no digital zoom). Microphoto processing was performed using the ImageJ 1.53k program (version for public use). The criterion for including a microphoto in the calculation of indicators was the presence of an ingrown implant fiber in the preparation or a cavity surrounding the implant.

Results. The zone adjacent to the implant, with a width of about 50 µm ("the zone of changes in adjacent tissues") significantly differs from the "zone of changes in distant tissues" by a more pronounced inflammatory reaction due to a larger absolute number of lymphocytes (р = 0.019 and fibroblasts (р = 0.017), giant cells of foreign bodies (р < 0.001), larger vascular area (р < 0.001) and extravasations (р = 0.002). The study of the "zone of changes in adjacent tissues" is of key importance in assessing the local response of the body to implantation. The key zones of the implantation area are identified: "the cavity surrounding the implant", "the zone of changes in adjacent tissues", "the zone of changes in distant tissues". The calculation of indicators within these zones allows you to get more detailed results when comparing study groups in the experiment.

Conclusion. An effective method for assessing the reaction of tissues in the implantation area after prosthetic hernia repair in an experiment using new digital imaging technologies that can be used using a conventional optical microscope and standard staining methods is proposed.
Prognostic significance of the logistic regression model for assessing the risk of recurrence in patients with prostate cancer after radical prostatectomy
Authors: Reva S. A. , Arnautov A. V. , Klitsenko O. A. , Petrov S. B.
Published: December 2022

Purpose of the study. The study’s objective is to investigate the influence of risk factors for recurrence of prostate cancer (PCa) after radical surgical treatment on the unfavourable course of recurrence of the disease with the formation of a set of the most significant factors of a model that reflects the likelihood of relapse.

Materials and methods. A retrospective analysis of clinical, pathomorphological and perioperative parameters of 803 patients with PCa after radical prostatectomy was carried out. By means of logistic regression, a model for assessing the risk of recurrence for patients with prostate cancer was built, which included 7 indicators, one of which was measured by quantity (time between biopsy and start of treatment) and six categorical ones (ISUP grade group, cT, cN+, positive surgical margin, PSA level after surgery, pN+). The construction of a logistic regression model consisted in obtaining a characteristic of the logistic function Ψ for the standard equation y = exp(ψ) / (1 + exp(ψ)).

Results. Substituting the coefficients obtained for each of the indicators, we obtain Ψ to assess the risk of relapse Ψ = 0.485 × X1+ 1.937 × X2 + 0.789 × X3 + 3.229 × X4 + 0.443 × X5 + 0.880 × X6 + 0.015 × X7–6.65. In the resulting formula, each of the regression coefficients describes the size of the contribution of the corresponding factor. In our case, all regression coefficients were positive, which means that this factor increases the overall risk of relapse. The quality of the resulting model is determined by the chi-square = 284.3; p < 0.001; OR = 28.45. The sensitivity of this model was 86.6 %, specificity 81.5 %, diagnostic accuracy 82.7 %.

Conclusion. This model makes it possible to obtain the probability of recurrence after radical prostatectomy depending on the severity of a specific set of predictive signs (a positive effect is predicted for y > 0.5, a negative one for y ≤ 0.5) and the degree of influence of one or a group of predictive signs on the likelihood of relapse, such as the ISUP grade group, locally advanced disease, clinically detectable lymph node lesion, positive surgical margin, PSA level of more than 0.09 ng/ml 1 month after surgery, the presence of regional metastases and the time between biopsy and the start of treatment.
Intelligent Mobile Edge Computing Integrated with Blockchain Security Analysis for Millimetre-Wave Communication
Authors: K Priyadarsini , Chandana Sri Lakshmi , Samaniego Severo Simón Calderón , Chaudhary Dr. Megha Gupta , Vekariya Dr. Vipul , Chaturvedi Mr. Abhay
Published: December 2022

With the increase in number of devices enabled the Internet of Things (IoT) communication with the centralized cloud computing model. With the implementation of the cloud computing model leads to increased Quality of Service (QoS). The cloud computing model provides the edge computing technologies for the real-time application to achieve reliability and security. Edge computing is considered the extension of the cloud computing technology involved in transfer of the sensitive information in the cloud edge to increase the network security. The real-time data transmission realizes the interaction with the high frequency to derive improved network security. However, with edge computing server security is considered as sensitive privacy information maintenance. The information generated from the IoT devices are separated based on stored edge servers based on the service location. Edge computing data is separated based in edge servers for the guaranteed data integrity for the data loss and storage. Blockchain technologies are subjected to different security problem for the data integrity through integrated blockchain technologies. This paper developed a Voted Blockchain Elliptical Curve Cryptography (VBECC) model for the millimetre wave application. The examination of the blockchain model is evaluated based on the edge computing architecture. The VBECC model develop an architectural model based Blockchain technology with the voting scheme for the millimetre application. The estimated voting scheme computes the edge computing technologies for the estimation of features through ECC model. The VBECC model computes the security model for the data transmission in the edge computing-based millimetre application. The experimental analysis stated that VBECC model uses the data security model ~8% increased performance than the conventional technique.
Experimental Performance Evaluation and Frame Aggregation Enhancement in IEEE 802.11n WLANs
Authors: Hajlaoui Nasreddine , Jabri Issam , Jemaa Maher Ben
Published: December 2022

The IEEE 802.11n standard promises to extend today’s most popular WLAN standard by significantly increasing reach, reliability, and throughput. Ratified on September 2009, this standard defines many new physical and medium access control (MAC) layer enhancements. These enhancements aim to provide a data transmission rate of up to 600 Mbps. Since June 2007, 802.11n products are available on the enterprise market based on the draft 2.0. In this paper we investigate the effect of most of the proposed 802.11n MAC and physical layer features on the adhoc networks performance. We have performed several experiments in real conditions. The experimental results demonstrated the effectiveness of 802.11n enhancement. We have also examined the interoperability and fairness of 802.11n. The frame aggregation mechanism of 802.11n MAC layer can improve the efficiency of channel utilization by reducing the protocol overheads. We focused on the effect of frame aggregation on the support of voice and video applications in wireless networks. We also propose a new frame aggregation scheduler that considers specific QoS requirements for multimedia applications. We dynamically adjust the aggregated frame size based on frame's access category defined in 802.11e standard.
Combined-order Algorithm using Promethee Method Approach and Analytic Hierarchy Decision for Chunk Allocation in LTE Uplink Systems
Authors: Fahmi Arfianto , Asvial Muhamad , Gunawan Dadang
Published: December 2022

The problem of chunk-based resource allocation for the uplink of Long Term Evolution is investigated. In this paper, a combined order using the promethee method and analytic hierarchy decision for chunk allocation algorithm is proposed. The utility of each order is sorted based on promethee method approach so that the utility of each order could be approximated as the average of all criteria on each order. To decide the best allocation, analytic hierarchy process score is assigned to its order based on their decision criteria weighting factor to find the best allocation. Using a particular weighting factor, the proposed algorithms outperform the previous mean greedy algorithms which use user-order allocation in term of spectral efficiency and data rate fairness without increase the time complexity. It also outperform iterative swapping chunk algorithm in term of  data rate fairness.
A Game Theory based Contention Window Adjustment for IEEE 802.11 under Heavy Load
Authors: Ghazvini Mahdieh , Movahedinia Naser , Jamshidi Kamal
Published: December 2022

The 802.11 families are considered as the most applicable set of standards for Wireless Local Area Networks (WLANs) where nodes make access to the wireless media using random access techniques. In such networks, each node adjusts its contention window to the minimum size irrespective of the number of competing nodes, so in saturated mode and excessive number of nodes available, the network performance is reduced due to severe collision probability. A cooperative game is being proposed to adjust the users’ contention windows in improving the network throughput, delay and packet drop ratio under heavy traffic load circumstances. The system’s performance evaluated by simulations indicate some superiorities of the proposed method over 802.11-DCF (Distribute Coordinate Function).