Abstract 1200: 25OH vitamin D concentrations are associated with both higher and lower incidence of specific cancers
Authors: Vojdeman Fie J. , Madsen Christian M. , Durup Darshana , Frederiksen Kirsten , Olsen Anja , Hansen Louise , Heegaard Anne-Marie , Lind Bent S. , Tjønneland Anne , Jørgensen Henrik L. , Schwarz Peter 
Published: August 2018

This study examined the association between concentrations of 25OH vitamin D and cancer incidence in individuals from the Capital Region of Denmark who had 25OH vitamin D analyzed in serum via their general practitioner between April 2004 and January 2010 (CopD). CopD data were linked to the Danish Cancer Registry, the National Patient Registry and the Danish Civil Registration System as of December 2014.

CopD consists of 246,858 individuals with 25OH vitamin D analyses. Individuals diagnosed with cancer prior to their 25OH vitamin D analysis (N=29,614) were excluded. The population analyzed in the study (217,244 individuals) had a mean level of 25OH vitamin D of 50.2 nmol/L, a mean age of 49.1 years (SD 20.1), female predominance (65.3%), and low comorbidity burden (Charlson Comorbidity index (CCI) ≥1 in 20.5%).

Cox regression models with time since blood sampling as the underlying time scale adjusted for age in one year intervals, sex, month of sampling, and CCI as strata variables were performed in SAS 9.4 (SAS Institute, Cary, USA). P-values less than 0.05 were considered statistically significant.

The study population experienced a total of 18,359 incident cancers during the follow-up period. Non-melanoma skin cancer was the most frequent form of cancer, followed by breast-, lung-, and prostate cancer (Table). In the adjusted analysis higher levels of 25OH vitamin D in increments of 10 nmol/L were associated with higher incidence of non-melanoma- and melanoma skin cancer, as well as prostate- and hematological cancers, but lower incidence of lung cancer. Excluding those diagnosed with cancer within 5 years of blood sampling, revealed similar results (Table).

In conclusion, higher concentrations of 25OH vitamin D are associated with both higher and lower incidence of cancer depending on cancer type in CopD. Thus, in a population from general practice we find higher 25OH vitamin D concentrations are associated with the incidence of skin-, prostate and hematological cancers.

Hazard ratios (HR) per 10nmol/L increase in 25OH vitamin D.Adjusted HR for allHR for cancer after 5+ yearsN casesHR95% ClpN casesHR95% ClpSkin cancerNon-melanoma50451.091.09-1.10&lt;0.000110621.111.09-1.13&lt;0.0001Melanoma6841.101.08-1.13&lt;0.00011301.141.08-1.20&lt;0.0001Sex specific cancersBreast21671.000.99-1.020.644551.020.99-1.050.21Ovary2540.990.94-1.030.58530.980.89-1.080.68C. Uteri3470.990.96-1.030.71900.990.92-1.060.71Prostate14701.051.03-1.07&lt;0.00012211.091.04-1.150.0002Tobacco related cancersLung17070.950.93-0.97&lt;0.00013180.930.89-0.980.003Colon11080.980.96-1.000.102220.970.93-1.030.32Rectum4610.980.94-1.010.18880.980.91-1.060.67Urinary10160.990.96-1.010.342130.980.93-1.040.50Other cancersHematological9681.031.01-1.060.0041811.081.03-1.130.002Central Nervous System incl. eye6891.000.98-1.030.871441.000.95-1.060.94

Citation Format: Fie J. Vojdeman, Christian M. Madsen, Darshana Durup, Kirsten Frederiksen, Anja Olsen, Louise Hansen, Anne-Marie Heegaard, Bent S. Lind, Anne Tjønneland, Henrik L. Jørgensen, Peter Schwarz. 25OH vitamin D concentrations are associated with both higher and lower incidence of specific cancers [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 1200.