bluuebunny/crossref_metadata_2025 huggingface dataset:
Free-floating Planets, Survivor Planets, Captured Planets, and Binary Planets from Stellar Flybys
Authors: Yu Fangyuan , Lai Dong
Published: July 2024

In star clusters, close stellar encounters can strongly impact the architecture of a planetary system or even destroy it. We present a systematic study of the effects of stellar flybys on two-planet systems. When such a system experiences flybys, one or both planets can be ejected, forming free-floating planets (FFPs), captured planets (CPs) around the flyby star, and free-floating binary planets (BPs); the remaining single-surviving planets (SSPs) can have their orbital radii and eccentricities greatly changed. Through numerical experiments, we calculate the formation fractions (or branching ratios) of FFPs, SSPs, CPs, and BPs as a function of the pericenter distance of the flyby, and use them to derive analytical expressions for the formation rates of FFPs, SSPs, CPs and BPs in general cluster environments. We find that the production rates of FFPs and SSPs are similar (for the initial planet semimajor axis ratio a
1/a
2 = 0.6–0.8), while the rate for CPs is a few times smaller. The formation fraction of BPs depends strongly on a
1/a
2 and on the planet masses. For Jupiter-mass planets, the formation fraction of BPs is always less than 1% (for a
1/a
2 = 0.8) and typically much smaller (≲0.2% for a
1/a
2 ≲ 0.7). The fraction remains less than 1% when considering 4M
J planets. Overall, when averaging over all flybys, the production rate of BPs is less than 0.1% of that of FFPs. We also derive the velocity distribution of FFPs produced by stellar flybys, and the orbital parameter distributions of SSPs, CPs, and BPs. These results can be used in future studies of exotic planets (including FFPs) and planetary systems.
Constraining Possible γ-Ray Burst Emission from GW230529 Using Swift-BAT and Fermi-GBM
Authors: Ronchini Samuele , Bala Suman , Wood Joshua , Delaunay James , Dichiara Simone , Kennea Jamie A. , Parsotan Tyler , Raman Gayathri , Tohuvavohu Aaron , Adhikari Naresh , Bhat Narayana P. , Biscoveanu Sylvia , Bissaldi Elisabetta , Burns Eric , Campana Sergio , Chandra Koustav , Cleveland William H. , Dalessi Sarah , De Pasquale Massimiliano , García-Bellido Juan , Gasbarra Claudio , Giles Misty M. , Gupta Ish , Hartmann Dieter , Hristov Boyan A. , Hui Michelle C. , Kashyap Rahul , Kocevski Daniel , Mailyan Bagrat , Malacaria Christian , Nakano Hiroyuki , Principe Giacomo , Roberts Oliver J. , Sathyaprakash Bangalore , Shao Lijing , Troja Eleonora , Veres Péter , Wilson-Hodge Colleen A.
Published: July 2024

GW230529 is the first compact binary coalescence detected by the LIGO–Virgo–KAGRA collaboration with at least one component mass confidently in the lower mass gap, corresponding to the range 3–5 M
⊙. If interpreted as a neutron star–black hole merger, this event has the most symmetric mass ratio detected so far and therefore has a relatively high probability of producing electromagnetic (EM) emission. However, no EM counterpart has been reported. At the merger time t
0, Swift-BAT and Fermi-GBM together covered 100% of the sky. Performing a targeted search in a time window [t
0 − 20 s, t
0 + 20 s], we report no detection by the Swift-BAT and Fermi-GBM instruments. Combining the position-dependent γ-ray flux upper limits and the gravitational-wave posterior distribution of luminosity distance, sky localization, and inclination angle of the binary, we derive constraints on the characteristic luminosity and structure of the jet possibly launched during the merger. Assuming a top-hat jet structure, we exclude at 90% credibility the presence of a jet that has at the same time an on-axis isotropic luminosity ≳1048 erg s−1 in the bolometric band 1 keV–10 MeV and a jet opening angle ≳15°. Similar constraints are derived by testing other assumptions about the jet structure profile. Excluding GRB 170817A, the luminosity upper limits derived here are below the luminosity of any GRB observed so far.
Chilomycterus reticulatus (Actinopterygii: Tetraodontiformes: Diodontidae) in the southern Sicilian waters, central Mediterranean Sea
Authors: Zava Bruno , Corsini-Foka Maria , Scannella Danilo , Insacco Gianni , Deidun Alan , Crobe Valentina , Tinti Fausto
Published: July 2024

A recently discovered fish specimen representing the family Diodontidae has been documented in the waters off Mazara del Vallo in southwest Sicily, Italy. A detailed description of the morphological and meristic characteristics of the specimen is reported. Molecular identification was performed through sequence analysis of the Cytochrome Oxidase subunit I (COI). The specimen was identified as Chilomycterus reticulatus (Linnaeus, 1758) both morphologically and genetically. The finding marks the third confirmed record of Chilomycterus reticulatus in the Mediterranean Sea and Italian waters. The significance of the presence of this uncommon fish in the basin is briefly discussed, shedding light on its occurrence and potential implications.
Hypercalcemia, Cinacalcet, and Bipolar Schizoaffective Disorder
Authors: Moukharskaya Julia , Marino Anna , Miller Christopher , Pandian Shantha G. , Rodriguez Juan F. , Peiris Alan N.
Published: July 2024

CME Educational Objectives

1.

Name some distinctive clinical and laboratory features of lithium-induced hyperparathyroidism.

2.

List current clinical indications and monitoring pertaining to cinacalcet use.

3.

Define the potential benefit of cinacalcet use in the case of mental status changes associated with lithium-induced hyperparathyroidism, if more traditional therapies, such as surgery, do not apply.
Solvability of fractional differential system with parameters and singular nonlinear terms
Authors: Wang Ying , Guo Limin , Zi Yumei , Li Jing
Published: July 2024

In this article, we consider the parametric high-order fractional system with integral boundary value conditions involving derivatives of order $ p $-$ q $. With the aid of the fixed-point theorem, an exact interval from the existence to the solution of the system will be obtained, under the condition that the nonlinearities of the system may have singularities. Finally, we provide an instance to show the practicality of the primary outcomes.
« ¡Democracia real antes ! » : Genèse de mobilisations citoyennes pour la démocratie participative dans l’Espagne pré-15M
Authors: Rull Jan Mathias
Published: July 2024

L’article se penche sur quelques initiatives citoyennes de promotion de la démocratie participative dans l’Espagne de la première décennie du XXIe siècle. Celles-ci ont été rares, mais constituent d’une certaine manière des précurseurs des Indignés espagnols, dont une des revendications centrales était l’accroissement de la participation citoyenne. Après avoir présenté ces initiatives (lieu, années, revendications précises, degré d’obtention), l’on s’attarde sur la nature des groupements qui les ont portées. On constate que derrière des collectifs nouvellement créés se trouvent des organisations agissant de longue date sur le territoire. On s’interroge ensuite sur les raisons qui ont amené ces acteurs traditionnels du lieu à formuler des revendications novatrices. Nous verrons alors que l’approfondissement de la démocratie locale ne constituait pas leur seule motivation. Pour finir, le texte avance des éléments qui ont pu contribuer à faire que ces mobilisations non seulement adviennent, mais s’installent dans la durée.
Naître vers la fin : circularités dans Alumbramiento de Víctor Erice
Authors: Rodrigo Miguel
Published: July 2024

Dans une filmographie où le récit est souvent fortement affaibli au profit d'une représentation directe du temps, Alumbramiento constitue une exception : ici la narration, agissant comme un véritable moteur à explosion, en raison de sa force relègue le temps à son statut classique de mesure du mouvement. Si l'attachement à un certain cinéma de la contemplation est toujours présent dans les plans que l'on peut qualifier de descriptifs, la ligne de force d'Alumbramiento est bien une flèche parcourant, imparable, la distance qui sépare le début du film de sa fin. Paradoxalement, le film le plus narratif d'Erice, celui qui s'appuie le plus sur le caractère linéaire et irréversible du temps, est en même temps celui où la poétique de la circularité, présente chez le cinéaste depuis son premier long-métrage, prend le plus de place et atteint son expression la plus aboutie. Organiquement intégrées dans la progression de l'action, l'ensemble des circularités parsemant Alumbramiento, à commencer par celle de sa structure, sont une force d'ordre involutif qui pourtant ne peut se déployer qu'à l'intérieur d'un temps forcément progressif. L'article se propose d'analyser la façon dont cette tension est construite, ainsi que ses répercussions concernant la démarcation, peut-être trop réductrice, entre temps linéaire et temps circulaire, tant sur le plan filmique que sur le plan du réel.
Beckett « admirateur » de Proust
Authors: Parisse Lydie
Published: July 2024

En 1931, à l’âge de 23 ans, Samuel Beckett publie en anglais une
étude sur Proust commandée par un éditeur londonien, et qui paraîtra
seulement à Paris en traduction française en 1990. Se démarquant de
l’apologie, il entre dans la compréhension des ressorts profonds de
l’œuvre proustienne, tout en dressant un autoportrait de lui-même et
des hantises qui traverseront son œuvre future. Sous la double
influence de Joyce et de Schopenhauer, il s’interroge sur les
épiphanies proustiennes et explore la triple expérience de la
dépossession qui habite l’écriture de À la recherche du temps perdu :
dépossession du temps, dépossession de l’autre, dépossession de soi.
S’il se défend alors d’être un « admirateur » de l’œuvre proustienne,
celle-ci marquera cependant ses textes d’une empreinte durable.
Perec à la lumière de Proust, effacements et résurgences de la mémoire
Authors: Roumette Julien
Published: July 2024

Perec a lu Proust assez tardivement, mais sa lecture a contribué à
structurer sa réflexion sur le temps, la mémoire et l’écriture.
Marquée par le traumatisme, l’oubli, l’effacement, l’absence, son
œuvre est traversée de tensions contraires, à la fois accablée par le
constat de la perte et hantée, en réaction, par le désir de retrouver
un passé englouti, de parvenir à en faire renaître des bribes ou des
fragments. Ce lien fondateur à la mémoire la rend sensible à l’horizon
proustien du temps retrouvé par la création artistique. Des premiers
romans où le passé est une dimension presque interdite, à la structure
inhibante de W ou le souvenir
d’enfance, puis à des œuvres moins ambitieuses mais où se révèle
une part vivante des souvenirs, comme Je me souviens, et enfin à La Vie mode d’emploi qui fait
du lien entre mémoire et création un enjeu romanesque, Proust éclaire
utilement l’écriture de la mémoire chez Perec, aussi bien par ses
impasses que par certaines proximités.
Simples d’esprit, « bon[s] en émotion »
Authors: Vignes Sylvie
Published: July 2024

Nombreux dans la littérature actuelle, les narrateurs et
personnages focaux simples d’esprit, choisis précisément en raison de
la limitation de leurs compétences en matière de compréhension du
monde et d’expression, nous apparaissent comme les descendants du
Benjy de Faulkner. À travers l’étude d’une nouvelle de Marie-Hélène
Lafon et des romans d’Anne Hébert, Claude Pujade-Renaud et Hubert
Mingarelli, on se demande ici en quoi et comment la privation de
culture, de sens critique, de maturité intellectuelle, voire de santé
mentale peut paradoxalement apporter une richesse supplémentaire au
récit, comme, déjà, Le Bruit
et la Fureuren donnait l’exemple en 1929.
Les armées et le gouvernement de l’Empire
Authors: Carrié Jean-Michel
Published: July 2024

L’article propose une synthèse de nos connaissances sur l’appareil
militaire romain durant la période 284-410 apr. J.-C, en privilégiant
les aspects qui ont donné lieu aux débats les plus animés et ceux dont
les recherches récentes ont particulièrement fait progresser la
connaissance. L’objectif est d’offrir une orientation utile dans une
bibliographie débordante, en tenant compte des facilités ou
difficultés d’accès.
Le cursus publicus
Authors: Crogiez-Pétrequin Sylvie
Published: July 2024

Il s’agira de faire, en même temps qu’un bilan historiographique,
le point sur les inscriptions et les textes à notre disposition pour
comprendre les évolutions de la « poste impériale » entre 284 et 410
de notre ère. Après la présentation rapide de ce qui est transporté
par ce service, on se penchera sur son organisation administrative :
les organes centraux, ceux des provinces et des cités ; son personnel
à tous les niveaux, hommes (manceps, agens in rebus ; et les préfets des véhicules dont
la fonction semble disparaître entre 326 et 365) et animaux ; et son
financement. Le corpus documentaire afférent à la période considérée
se répartit entre inscriptions, papyri,
quelques textes d’historiens antiques et surtout les lois contenues
dans le Code Théodosien, et dans une moindre
mesure dans le Code Justinien. 103 lois
concernent la période entre 315 et 407.
Moulage et surmoulage. Réflexions sur la production en masse des terres cuites dans l’Égypte gréco-romaine
Authors: Galbois Estelle
Published: July 2024

Les figurines de terre cuite moulées en creux ont été fabriquées en
nombre en Égypte aux époques ptolémaïque et romaine. L’introduction du
moulage intégral, véritable révolution technique, a rendu possible une
production de masse répondant à de nouveaux besoins aussi bien à
Alexandrie que dans l’arrière-pays (ou chôra). Dans cette
contribution, nous nous focaliserons sur les procédés techniques mis
en œuvre pour fabriquer les figurines en série, le surmoulage tout
particulièrement. Nous nous interrogerons aussi sur une possible perte
du savoir-faire des artisans au fil du temps, et sur l’impact
potentiel que cela a pu avoir sur la consommation de ces
artefacts.
Mexico-Tenochtitlan de la cité à la ville
Authors: Maroudaye  Béatrice
Published: July 2024

L’article que nous présentons cherche à montrer par le biais de l’image comment la cité de Mexico-Tenochtitlán à été reconstruite et a développé à l’origine de la volonté espagnole son espace en créant des zones urbaines spécifiques fréquentées par les populations indiennes espagnoles, noires et métisses. Même si les lois hispaniques étaient strictes, cette réalité n’a pas été respectée pour les besoins du commerce et le mécanisme spatial dont ont hérité les populations locales. Au fil des siècles les représentations témoignent de la conservation des axes principaux de l’ancienne Mexico-Tenochtitlán et corroborent les dires des chroniqueurs et voyageurs ayant visité la ville. L’évolution des représentations laisse percevoir la disparition des lacs au profit de l’urbanisation inévitable réglée par des lois des différents gouvernements qui ont utilisé les symboles autoritaires du pouvoir sur le centre de Mexico.. Pourtant, les représentations récentes laissent entrevoir parallèlement le sentiment de gloire impérissable de l’ancienne Mexico-Tenochtitlán prédit par les chroniqueurs métis il y a 500 ans où est venu se greffer l’ancien souvenir de la ville associé à la projection d’une ville fictive. L’image permet de réhabiliter le souvenir de la société des anciens Mexicains dans une perspective moderne.
Javier Milei et la tradition politique argentine. Continuité et rupture
Authors: Stefanich Fernando
Published: July 2024

Autoproclamé libertarien, Milei a mis fin à l’hégémonie kirchnériste qui avait commencée en 2003 avec la présidence de Néstor Kirchner. Il assume ses fonctions le 10 décembre 2023, dans un contexte complexe : le pays traverse une crise importante et la société argentine est profondément divisée. C’est la grieta (la brèche), la frontière invisible qui sépare les Argentins.Dans le présent travail, nous nous proposons d’étudier la polarisation de la société argentine à travers la figure de Javier Milei.
Impact of Online Field Practice on Islamic Education Preservice Teachers
Authors: Alkandari Kalthoum
Published: July 2024

This study employed qualitative methods to examine the expectations, challenges, learning loss, and development of professional skills among preservice teachers of Islamic education as they engaged in online field practice. Interviews were conducted with individual participants and focus groups, and reflection papers were collected from 46 preservice teachers of Islamic education assigned to an online teaching practicum. Participants had mixed feelings about their online field practice due to a lack of experience and doubts about their preparedness and ability with virtual field practice. Results revealed they experienced setbacks, including a deficiency in pedagogical expertise for virtual instruction and challenges in promoting class communication and involvement online without in-person learning environments. However, virtual teaching, creativity, and improved cognitive abilities were encouraged. It is recommended that educational establishments offer supplementary assistance to preservice teachers trained during the pandemic to augment their professional growth .
An Experimental Study on Mechanical Properties of Concrete by Using Various Types of Coarse Aggregates of Different Quarries
Authors: Ali Shoaib , Ahmed Aqeel , Khan Abdul Rahim , Ahmed Zaheer , Anjum Naveed , Ali Moazam
Published: July 2024

This research study aims to conduct a comprehensive investigation of the mechanical properties of concrete in the specific context of Pakistan. It will utilize a variety of aggregate sources, including Sakhi Sarwar crush, Margallah crush, Sargodha crush, and Quetta crush. The primary objectives of the study encompass a thorough analysis of the physical and mechanical characteristics of these aggregates. Additionally, the study seeks to investigate how the choice of aggregate type affects the mechanical properties of concrete and how different mix designs impact the performance of the concrete. Ultimately, the research aims to identify the optimal mix design for each aggregate source and conduct a comparative evaluation of the resulting mechanical properties. The importance of this study lies in its potential to make a significant contribution to the construction industry in Pakistan. The findings are expected to offer valuable insights that can inform decisions regarding aggregate selection and enhance the optimization of concrete mix designs, there by leading to improved concrete performance, durability, and advancements in infrastructure development. Furthermore, this research aligns with sustainable development goals by promoting responsible consumption and production, sustainable urban development, climate action, and sustainable land use practices. It's worth noting that this study has certain limitations, such as its focus on a limited number of aggregate sources and its reliance on laboratory-based experiments. However, this research serves as a foundation for future studies and emphasizes the importance of collaboration, knowledge sharing, and ongoing research efforts to improve construction practices in Pakistan.
Factors Affecting the Use of Orange Line Metro Train Service by University Students
Authors: Batool Malieka , Gulzar Fakhra , Saghir Arsalan , Umar Muhammad
Published: July 2024

Public transport is a vital infrastructural facility that must be contiguous for the public to use. Orange Line Metro Train Service has improved the public transportation facility in Lahore. To evaluate its performance, a study is conducted on students of the University of Engineering and Technology. Four dependent variables were selected for the study; time, comfort/ convenience, safety/ security, and economic feature. A survey was conducted and results were evaluated using Cronbach’s Alpha value on dependent variables. Correlation analysis and basic statistical analysis were also used in data analysis. It was found that gender has no significant difference in the perception of comfort/convenience features. Additionally, it was found that comfort significantly impacts a person’s reuse of OLMRTS compared to other variables due to the high Cronbach’s alpha value.
Utilization of SiO2 for Assessing Bitumen Characteristics through Consistency Tests
Authors: Ishaq Muhammad Naveed , Anjum Naveed , Ahmed Zaheer , Javed Asad , Sidiqy Junaid , Khan Musharaf
Published: July 2024

Bitumen, a fundamental component of asphalt used in road construction, plays a vital role in determining the performance and longevity of pavements. The assessment of bitumen characteristics is crucial to ensure its suitability for specific applications and environmental conditions. This research paper explores the use of fumed silica, a high-purity, fine particulate form of silicon dioxide, as an additive in bitumen to improve its properties. The study investigates the impact of Fumed Silica SiO2 on the results obtained. The following tests, including the specific gravity test, penetration test, softening point test, and flash and fire test were used to determine the rheological characteristics of bitumen. In particular, the treated bitumen qualities were concentrated after performing lab testing by breaking down the rheological properties. The research aims to enhance the understanding of how SiO2 affects bitumen properties and its potential benefits in enhancing the performance of road pavements. According to this study, 0.1 wt. % of fumed silica produces the results mentioned above better than larger concentrations of fumed silica.
An Experiment Study of Concrete Caste with River Sand and with Varying Sizes and Percentages of Steel and Nylon Fibers
Authors: Adnan Muhammad , Ahmed Aqeel , Ahmed Zaheer , Anjum Naveed , Komal Munaza , Hussain Khalid
Published: July 2024

This research paper presents the findings of an experimental study conducted to investigate the influence of varying sizes and percentages of steel and nylon fibers on the mechanical and durability properties of concrete. The objective of this study was to explore the potential enhancements in concrete performance through fiber reinforcement, considering the two distinct fiber types - steel and nylon. A comprehensive testing program was devised, encompassing a wide range of fiber combinations to assess their individual and combined effects on concrete properties. The concrete specimens were prepared by incorporating different sizes (length and diameter) and proportions (percentage by volume) of steel and nylon fibers into the concrete mix. Mechanical properties, including compressive strength, tensile strength, and flexural strength, were evaluated to determine the impact of fiber reinforcement on the concrete's load-bearing capacity and resistance to cracking. Additionally, the durability properties, chloride ion penetration, and abrasion resistance, were assessed to understand the potential improvement in the concrete's long-term performance under adverse environmental conditions. The experimental results revealed significant variations in the mechanical and durability properties of the fiber-reinforced concrete compared to the conventional concrete mix. Steel fibers demonstrated superior performance in enhancing the concrete's load-carrying capacity and ductility, especially at higher percentages. On the other hand, nylon fibers exhibited exceptional resistance to and abrasion, contributing to improved durability. Notably, the steel and nylon fibers exhibited synergistic effects, leading to a balanced enhancement of mechanical and durability properties. In conclusion, this study provides valuable insights into the benefits of incorporating steel and nylon fibers in concrete, offering an effective means of optimizing the material's overall performance for diverse engineering applications. The results from this research can serve as a basis for developing more resilient and sustainable concrete structures, which can withstand harsh environmental conditions and contribute to the advancement of construction practices. Further exploration into the long-term behavior and cost-effectiveness of fiber-reinforced concrete is recommended for a comprehensive understanding of its feasibility in practical engineering applications.
Numerical Study on Flexural Behaviour of Steel-GFRP Hybrid-Reinforced Concrete Beams
Authors: Ifrahim Muhammad Saad , Sangi Abdul Jabbar
Published: July 2024

To alleviate the corrosion issue, GFRP bars are usually preferred over steel reinforcing bars. However, its application causes larger deflection and brittle failure of concrete members. To solve this, steel bars can be used in combination with GFRP bars to reduce deflection and enhance ductility. Steel-GFRP hybrid reinforced concrete is a relatively recent concept, as a result, it is still in the development stage. This study numerically examines the flexure response of concrete beams reinforced with hybrid reinforcement i.e., GFRP bars combined with steel. A total of five numerical models were developed for this investigation. The analysis methodology is based on the models developed for investigation of GFRP reinforced concrete beams which was validated with experimental studies. It is found that with an increase in the replacement percentage of steel in GFRP RC beams, the ultimate load is increased. Also, it is observed that there is a significant reduction in deflection in post-cracking and pre-steel yielding region along with enhancement in the attributes of ductility which is beneficial for serviceability aspects. The steel-GFRP hybrid-reinforced concrete beams were found to have failed by yielding of steel and subsequent concrete crushing.
Second chance in fertility: a comprehensive narrative review of redo micro-TESE outcomes after initial failure
Authors: Elbardisi Haitham , Bakircioglu Emre , Liu Wen , Katz Darren
Published: July 2024

When microdissection testicular sperm extraction (micro-TESE) fails, a redo procedure may be the only option for patients who want a biological child. However, there are many gaps of knowledge surrounding the procedure, which need to be addressed to help clinicians and patients make informed decisions. This review explores redo micro-TESE in the context of nonobstructive azoospermia (NOA). Literature was searched using Google Scholar, Medline, and PubMed. Search terms were “NOA” AND “second microdissection testicular sperm extractions” AND “redo microdissection testicles sperm extraction” AND “repeat microdissection testicular sperm extractions” AND “failed microdissection testicular sperm extractions” AND “salvage microdissection testicular sperm extractions”. Only original articles in English were included. A total of nine articles were included, consisting of four retrospective and five prospective studies. The time gap between the first and second micro-TESE varied from 6 months to 24 months. Most of the included studies reported successful surgical sperm retrieval (SSR) in the second micro-TESE in the range of 10%–21%, except in one study where it reached 42%. It has not been presented any definitive information about the use of hormonal treatment or the benefit of varicocelectomy prior to the second micro-TESE. Patients with hypospermatogenesis and Klinefelter syndrome (KS) had the highest chance of success in redo surgery. In conclusion, redo micro-TESE following a negative procedure can lead to sperm recovery in 10%–21%. Patients with hypospermatogenesis and KS have a higher chance of success. There is no enough evidence to conclude which is the best hormonal stimulation if any before a redo surgery.
Osteomyelitis of the Jaw Due to Mucormycosis after Coronavirus Disease 2019 Infection - A Prospective Study
Authors: Datarkar Abhay , Bhawalkar Amit , Shah Vartik , Manekar Varsha , Gadve Vandana , Daware Surendra , Walkey Damyanti , Gioia Francesca , Acero Julio
Published: July 2024

Introduction:

The objective of the study was to describe the incidence, clinical characteristics, treatment and outcome of patients with rhinocerebral coronavirus disease 2019-associated mucormycosis (CAM).

Materials and Methods:

We performed an unicentric observational study. A total of 113 cases of CAM were evaluated from January 2021 to June 2021. We described the overall incidence of CAM in Nagpur district up to June 2021, the clinical presentation of CAM, the subtype of CAM, the laboratory diagnosis, the type of surgical management in CAM, the pre-operative and 3-month post-operative C-reactive protein marker values, the post-operative healing and complications and the mortality rate.

Results:

The mean age of the patients was 38.8 years. Rhinomaxillary subtype was the most common. All patients underwent medical as well as surgical intervention as the treatment modality. There was mortality in two patients.

Discussion:

Study highlights the need for physicians to closely monitor coronavirus disease 2019 (COVID-19) patients, especially severe cases with pre-existing diabetes/receiving corticosteroid therapy and the need for patient education as early diagnosis and prompt treatment leads to better prognosis.
Impact of Early Diagnosis of Maxillofacial Metastases on Treatment and Patient Outcomes - A Retrospective Study
Authors: Turgeman Shahar , Turgeman Ilit , Emodi Omri , Wolff Amir , Rachmiel Adi
Published: July 2024

Introduction:

Maxillofacial metastases from distant primary sites account for less than 1% of cancer in the head-and-neck region and are often misdiagnosed as benign or inflammatory conditions. The purpose of this study was to describe the clinical characteristics of patients with maxillofacial metastases, treatment and outcomes.

Materials and Methods:

Subjects with head-and-neck cancer were identified from the institutional database. Descriptive statistics were employed.

Results:

Of 532 patients with head-and-neck cancer between 2008 and 2020, 15 (2.8%) had histologically verified metastatic lesions, of which 53.33% males with a mean age of 69 years. The median time from symptom onset to diagnosis was 17 days (range: 7–60). The mandible was the most common location (40%), followed by the parotid gland (33.33%) and maxilla (13.33%). Adenocarcinoma was the most frequent histology (60%), and half of the patients had extraoral manifestations. Tumour origin was gastrointestinal, lung (33.33% each), prostate (20%) and breast (13.3%). No predilection for tumour type or histology and location were seen. Radiographic features were non-specific, with computed tomography (CT) demonstrating periosteal reaction, bone expansion and lytic lesions and high variability in Positron Emission Tomography (PET) standardised uptake value (minimum: 2.0, maximum: 10.93 and mean: 4.14). Diagnosis led to altered treatment in 60%, more in extraoral than intraoral manifestations (71% vs. 37.5%); 40% received radiotherapy, 20% systemic treatment and none underwent surgery. Over half of the patients passed away within 6 months, median survival was 5 months, shorter in patients with intraoral than extraoral disease (3 vs. 13.2 months, P < 0.05).

Discussion:

Maxillofacial metastases have elusive manifestations and often warrant specific treatment. Prospective data should evaluate associations between timely diagnosis and symptomatic improvement and survival.
Unravelling the Complexity of Mucormycosis-A Rare Case Report
Authors: Deenadayalan N. , Pandyan P. Deepak Abraham , Satheesh C , Aparnaa M. , Samyo George Stephenson
Published: July 2024

Rationale:

Mucormycosis is a rare, life-threatening, invasive fungal infection often referred to as black fungus. It has gained significant attention due to its increasing incidence during the coronavirus pandemic of 2019.

Patient Concern:

An 8-month-old child, whose identity is being withheld, arrived at our clinic with her parents with the chief complaint of swelling in the upper lip and cheek.

Diagnosis:

Various laboratory procedures, including blood cultures and imaging scans were performed to determine the presence of mucormycosis.

Treatment:

Under general anaesthesia, decortication and resection was done surgically, followed by an intraoral elastomeric impression made over the resected region. Soft silicone splints as oral seals for the suckling reflex were made postoperatively within a week. Immediate post-operative therapeutic low-level laser therapy was done.

Outcome:

Wound healing has been achieved.

Take-away Lessons:

Multidisciplinary intervention provides the best outcomes for the successful treatment and rehabilitation of paediatric patients with mucormycosis of the facial region.
Improvement in Quality of Life after Laparoscopic or Robotic-assisted Sacrocolpopexy with a Single Anterior Mesh in Patients with Pelvic Organ Prolapse: A Retrospective Analysis from a Single Institution
Authors: Kinouchi Riyo , Yoshida Kanako , Kawakita Takako , Yasui Toshiyuki , Iwasa Takeshi , Kato Takeshi
Published: July 2024

Objectives:

Pelvic organ prolapse (POP) is a significant health-care problem for older women. We have treated POP surgically using laparoscopic sacrocolpopexy (LSC) or robotic-assisted sacrocolpopexy (RSC). The original LSC and RSC procedures were done with anterior and posterior meshes; however, the use of the single mesh procedure is increasing because of its simplicity and safety. There have been few reports about the change in quality of life (QOL) using the single mesh procedure. Therefore, the present study aimed to retrospectively evaluate the change in QOL by LSC and RSC using a single anterior mesh for women without posterior compartment prolapse.

Materials and Methods:

We performed LSC or RSC using a single anterior mesh in 52 patients who had POP without posterior vaginal wall prolapse between August 2018 and October 2022. We assessed the QOL before and after surgery using prolapse-QOL (P-QOL) questionnaires.

Results:

All patients who received LSC or RSC with a single anterior mesh left the hospital as scheduled without severe perioperative complications. There were no instances of wound infection or vaginal mesh extrusion. The recovery rate of questionnaires was 63.5% (33/52). All QOL score domains improved significantly, and there were no questionnaire parameters that worsened.

Conclusion:

LSC or RSC using only a single anterior mesh improves P-QOL with a low incidence of surgical complications for POP patients who did not have posterior vaginal wall prolapse. LSC or RSC with a single anterior mesh may be a prospective new procedure for POP.
Pregnancy in Infertile Patient after Intrauterine Adhesiolysis by Multitherapeutic Strategy: A Case Report and Mini-review
Authors: Dinh Hoang The , Nguyen Nhan Trong , Tran An Nguyen Phuong
Published: July 2024

Asherman’s syndrome, characterized by intrauterine adhesions (IUAs), represents a significant challenge in the field of female infertility. Hysteroscopic adhesiolysis has emerged as the gold standard for both the diagnosis and treatment of Asherman’s syndrome. Understanding the intricate relationship between Asherman’s syndrome, uterine adhesiolysis, and infertility is crucial for guiding comprehensive and effective management strategies. The success of the treatment is contingent upon preventing adhesion recurrence, particularly in cases of severe IUAs. This is the first case, in which we employed a multifaceted preventive approach, utilizing hyaluronic gel, Foley balloon, hormonal therapy, and platelet-rich plasma, achieving successful pregnancy following embryo transfer despite the presence of severe IUAs. The patient, a 35-year-old female, underwent one cesarean section following in vitro fertilization and required dilation and curettage due to retained products of conception. The patient presented with oligohemorrhage, and the uterine lining was thin while using hormones for endometrial preparation. The diagnosis of severe IUAs was confirmed through ultrasound and hysteroscopic examination of the uterine cavity. The patient underwent hysteroscopic adhesiolysis with a preventive approach using a combination of methods. Subsequently, the patient underwent a second-look hysteroscopy to assess the uterine cavity and achieved successful embryo transfer. The patient carried the pregnancy to 38 weeks and underwent repeated cesarean section due to the vertex-vertex presentation of the twins.
Integrating High-intensity Focused Ultrasound with Chemotherapy for the Treatment of Invasive Hydatidiform Mole in Reproductive-age Women
Authors: Pan Yongmiao , Lin Kaiqing , Hu Ying , Song Xiaohong , Xu Linjun , Zhou Zhenfeng , Xie Di , Xue Yuan
Published: July 2024

Invasive hydatidiform mole, a form of gestational trophoblastic neoplasm in reproductive-age women, poses a significant threat to life due to its associated signs and symptoms. This case report details the management of a 24-year-old Chinese woman with no prior pregnancy history, who presented at our hospital 23 days postcurettage, experiencing persistent vaginal bleeding for 3 days. While two rounds of chemotherapy effectively reduced human chorionic gonadotropin levels, a subsequent magnetic resonance imaging (MRI) revealed suspicious growth lesions in the uterus. High-intensity focused ultrasound (HIFU) treatment was administered under ultrasound guidance, resulting in notable grayscale changes to optimize the efficacy of chemotherapy and restrict lesion progression. Subsequent ultrasound and MRI assessments during follow-up demonstrated a transparent texture in the muscle layer at the lesion site. This case suggests that the combination of chemotherapy and HIFU, guided by ultrasound, may represent a promising therapeutic approach for managing invasive hydatidiform mole.
Ophthalmological involvement in rosacea: Ocular rosacea
Authors: Kansal Naveen Kumar , Singh Anupam , Kumar Barun
Published: July 2024

Rosacea is a common, chronic disorder that can present with a variety of cutaneous or ocular manifestations. Cutaneous involvement primarily affects the central face, with findings, such as persistent centrofacial redness, papulopustules, flushing, telangiectasia, and phymatous skin changes (e.g., rhinophyma). Ocular involvement may manifest with lid margin telangiectases, conjunctival injection, ocular irritation, or other signs and symptoms. In this review, we focus on the ophthalmological manifestations of rosacea and its management.
Eccrine hidrocystomas: A distinct clinicopathologic entity and a potential mimicker of malignancy—A case series with a review of the literature
Authors: Singh Hem Narayan , Dogra Natasha , Shelly Divya , Das Amit Kumar , Pant Manoj
Published: July 2024

Purpose:

Eccrine hidrocystomas are a rare, benign cystic lesion of the skin primarily found in the head and neck region, with a predilection for the periorbital area in adult females. These cysts typically present as small, tense, thin-walled structures ranging from 1 to 6 mm in size, occurring either as solitary entities or in multiples. Despite their benign nature, eccrine hidrocystomas pose diagnostic challenges due to their resemblance to malignant lesions both clinically and in imaging studies. This study aims to explore the varied clinical presentations of eccrine hidrocystoma and discuss the complexities associated with its diagnosis.

Materials and Methods:

Five cases were included in the study along with a comprehensive review of the existing literature. We emphasize the importance of accurate and early diagnosis for appropriate management. The clinical manifestations of eccrine hidrocystoma often overlap with features suggestive of malignancy, underscoring the necessity for meticulous histopathological examination to definitively differentiate between these entities. This differentiation is crucial as it impacts treatment decisions and patient outcomes.

Conclusion:

In conclusion, our study underscores the diagnostic dilemmas posed by eccrine hidrocystoma, highlights its potential mimicry of malignancy, and emphasizes the significance of histopathological evaluation in achieving accurate diagnosis and guiding management strategies.
Exploring central serous chorioretinopathy: Insights from a series of pigment epithelial detachment cases
Authors: Gayatri Dasari , Bharadwaj Vedula
Published: July 2024

Aim:

This study aimed to investigate central serous chorioretinopathy (CSCR) by analyzing clinical patterns using spectral-domain optical coherence tomography (SD-OCT).

Methods:

A retrospective study on individuals diagnosed with CSCR was conducted at the Gitam Institute of Medical Sciences and Research between January 2022 and December 2022. Comprehensive medical and ocular histories were documented, including best-corrected visual acuity, slit-lamp examination, indirect ophthalmoscopy, and SD-OCT analysis. Macular thickness and the presence of pigment epithelial detachments (PED) were carefully recorded, while patients with other macular conditions were excluded.

Results:

The study comprised nine patients (nine eyes) aged 31 to 48 (mean age: 41.33). Of these, seven were male (77.78%), and two were female (22.22%). Three cases (33.33%) affected the left eye, while six (66.67%) involved the right eye—the mean macular thickness measured 502.56 μm, from 406 to 819 μm. Notably, five out of the nine eyes exhibited PEDs. Among these cases with PED, four of the five eyes demonstrated macular thickness exceeding 482 μm, with only one eye measuring 406 μm in thickness.

Conclusion:

CSCR predominantly affects males at an average age of 41. The integration of SD-OCT with indirect ophthalmoscopy is imperative for comprehending CSCR patterns. The substantial variation in macular thickness underscores the necessity for individualized assessment and treatment strategies. The presence of PED correlates with heightened macular thickness, potentially influencing recovery duration and visual acuity outcomes. While this study contributes to the existing knowledge base, further extensive research is essential to validate and enhance our understanding of CSCR.
Dual testing for SARS Covid-19 in asymptomatic medico-legal cases: Experience and suggestions
Authors: Kannuri Sriram , Patil Rajashri , Mukhida Sahjid , Shinde Archana , Akmar Gajanan , Methe Bhagwan , Bhaumik Shalini , Das Nikunjakumar
Published: July 2024

Context:

A person caught by police known as a Medical Legal Case (MLC) should be negative for Covid-19 before they are presented in court. Police officers always insist on collecting a sample from MLC patients for both the rapid antigen test (RAT) and reverse transcriptase polymerase chain reaction (RTPCR). Using both tests for the same patient at the same time is a waste of resources. The aim of the study is to analyze and compare Covid-19 RAT and RTPCR testing results in MLC cases and to find out the need to prevent resource wasting due to dual tests.

Methods:

The study was conducted for 6 months on all the MLC patients who were brought by the police officer for Covid-19 testing at the center. Oropharyngeal or nasopharyngeal swabs were collected in viral transport media for Covid-19 RTPCR and RAT test. RAT is performed at the collection center, while viral transport media is transported to an authorized testing center for RTPCR.

Result:

All 156 patients’ RAT and RTPCR tests were performed as per requirements and rules. Only two specimens (1.28%) reported positive for Covid-19 in RTPCR and other samples (98.71%) reported negative for Covid-19 in RTPCR, while all 156 samples (100%) were reported negative for Covid-19 by RAT test.

Conclusion:

As per the current study, we can consider the RAT results for presenting the criminal person to court, but for sending them to prison, RTPCR is recommended to prevent the spread of disease.
Pyrexia of unknown origin in a child with chronic diffuse alopecia- A predictor of pediatric systemic lupus erythematosus
Authors: Divija Kamma S. , Murty Pemmaraju R. , Sneha Vanapalli R. , Pasagadugula Venkata K. , Sravani Kalagarla , Shree Macharla T.
Published: July 2024

Systemic lupus erythematosus (SLE) is a chronic prototypic autoimmune disorder characterized by the inflammatory and autoimmune reaction leading to protean systemic manifestations. The incidence of childhood-onset SLE has been estimated at an average of 0.6 per 1,00,000 children-years. Childhood-onset SLE has an aggressive course with renal and nervous systems being more involved than in adults. The latest validated Systemic Lupus International Collaborating Clinics (SLICC) criteria, which exhibited a higher sensitivity includes eleven clinical and six immunological items. This criteria has been validated in children. A multidisciplinary therapeutic approach is important due to the complexity of lupus in pediatric patients. We report a case of 12-year-old female child diagnosed as SLE due to its rare occurrence in the pediatric age group.
ST elevation acute myocardial infarction in young versus elderly: An observational study
Authors: Sharma Aakanksha , Gupta Monica , Kaur Jaspreet , Lehl Sarabmeet S.
Published: July 2024

Background:

ST elevation acute myocardial infarction (AMI) is usually associated with marked morbidity and mortality, affecting both young and elderly populations.

Aims:

To compare the differences in clinical presentation, treatment, outcome, and comorbidity in elderly and young patients of ST elevation myocardial infarction (STEMI).

Methods:

A prospective study was conducted on 60 patients divided equally into two groups – above 60 years (Group A) and 60 years or below (Group B). The various parameters including clinical presentation, time of onset, type of AMI, medication, complications, and outcome were assessed. They were followed up for 1 month.

Results:

The proportion of males and females (M:F) was equal in Group A, and the M:F ratio was 2.75 in Group B. The mean duration of hospitalization was longer in elderly. Hypertension was the most common comorbid condition. About half of the elderly cohort had previous history of angina pectoris, and about one third had prior attacks of MI. Overall, a higher number of younger cohorts were thrombolyzed with streptokinase.

Conclusion:

Our study showed that there were noteworthy differences in clinical presentation, management, and outcome between elderly and young AMI patients. Early recognition of atypical features among elderly can lead to effective strategies and timely management.
Recognition of HLA-DPB1 alleles and their associated HLA haplotypes in 55 randomized unrelated Taiwanese individuals
Authors: Chen Shee-Ping , Lin Py-Yu , Yang Kuo-Liang
Published: July 2024

ABSTRACT

Objectives:

Here, we report the distribution of HLA-DPB1 alleles studied in a cohort of 55 randomly collected blood samples from unrelated Taiwanese individuals and the deduced most likely HLA haplotypes associated with the defined DPB1 alleles in the cohort. Our aim is to reveal the unprecedented data on the distribution of HLA-DPB1 alleles in the Taiwanese population and to find out the most probable HLA haplotypes associated with the HLA-DPB1 alleles detected.

Materials and Methods:

The material for this study was blood samples, preserved in K2EDTA and/or acid citrate dextrose anticoagulants. The blood donors were voluntary individuals of Tzu Chi Bone Marrow Donor Registry, Tzu Chi Stem Cells Center, Hualien Tzu Chi Hospital. Sequence-based typing of the Sanger’s sequencing method was performed for the HLA allelic typing. To discern the HLA-DPB1 alleles, exons 2 and 3 of the HLA-DPB1 locus were sequenced. Target exon sequence amplifications were achieved by polymerase chain reaction, and the resulting amplicons were sequenced by BigDye Terminator Cycle Sequencing Ready Reaction Kit according to the manufacturer’s protocols.

Results:

In the total number of 55 randomized unrelated Taiwanese individuals studied, we detected 11 different HLA-DPB1 alleles. DPB1*05:01 (44.54%) was the allele with the highest frequency observed and the next highest frequency allele found was DPB1*02:01 (17.27%), while DPB1*38:01 (0.90%) and DPB1*700:01N (0.90%) ranked the least observed DPB1 alleles.

Conclusion:

Our findings in this study may be useful in researches reinforcing the comprehensive understanding on the distribution of DPB1 alleles and their associated HLA haplotypes and their clinical applications in Taiwanese.