bluuebunny/crossref_metadata_2025 huggingface dataset:
Innate Lymphoid Cells in Intestinal Homeostasis and Inflammatory Bowel Disease
Authors: Saez Angela , Gomez-Bris Raquel , Herrero-Fernandez Beatriz , Mingorance Claudia , Rius Cristina , Gonzalez-Granado Jose M.
Published: July 2021

Inflammatory bowel disease (IBD) is a heterogeneous state of chronic intestinal inflammation of unknown cause encompassing Crohn’s disease (CD) and ulcerative colitis (UC). IBD has been linked to genetic and environmental factors, microbiota dysbiosis, exacerbated innate and adaptive immunity and epithelial intestinal barrier dysfunction. IBD is classically associated with gut accumulation of proinflammatory Th1 and Th17 cells accompanied by insufficient Treg numbers and Tr1 immune suppression. Inflammatory T cells guide innate cells to perpetuate a constant hypersensitivity to microbial antigens, tissue injury and chronic intestinal inflammation. Recent studies of intestinal mucosal homeostasis and IBD suggest involvement of innate lymphoid cells (ILCs). These lymphoid-origin cells are innate counterparts of T cells but lack the antigen receptors expressed on B and T cells. ILCs play important roles in the first line of antimicrobial defense and contribute to organ development, tissue protection and regeneration, and mucosal homeostasis by maintaining the balance between antipathogen immunity and commensal tolerance. Intestinal homeostasis requires strict regulation of the quantity and activity of local ILC subpopulations. Recent studies demonstrated that changes to ILCs during IBD contribute to disease development. A better understanding of ILC behavior in gastrointestinal homeostasis and inflammation will provide valuable insights into new approaches to IBD treatment. This review summarizes recent research into ILCs in intestinal homeostasis and the latest advances in the understanding of the role of ILCs in IBD, with particular emphasis on the interaction between microbiota and ILC populations and functions.
The Role of microRNAs in Cholangiocarcinoma
Authors: Shi Tingting , Morishita Asahiro , Kobara Hideki , Masaki Tsutomu
Published: July 2021

Cholangiocarcinoma (CCA), an aggressive malignancy, is typically diagnosed at an advanced stage. It is associated with dismal 5-year postoperative survival rates, generating an urgent need for prognostic and diagnostic biomarkers. MicroRNAs (miRNAs) are a class of non-coding RNAs that are associated with cancer regulation, including modulation of cell cycle progression, apoptosis, metastasis, angiogenesis, autophagy, therapy resistance, and epithelial–mesenchymal transition. Several miRNAs have been found to be dysregulated in CCA and are associated with CCA-related risk factors. Accumulating studies have indicated that the expression of altered miRNAs could act as oncogenic or suppressor miRNAs in the development and progression of CCA and contribute to clinical diagnosis and prognosis prediction as potential biomarkers. Furthermore, miRNAs and their target genes also contribute to targeted therapy development and aid in the determination of drug resistance mechanisms. This review aims to summarize the roles of miRNAs in the pathogenesis of CCA, their potential use as biomarkers of diagnosis and prognosis, and their utilization as novel therapeutic targets in CCA.
Whole Blood Transcriptome Characterization of 3xTg-AD Mouse and Its Modulation by Transcranial Direct Current Stimulation (tDCS)
Authors: Magri Chiara , Vitali Erika , Cocco Sara , Giacopuzzi Edoardo , Rinaudo Marco , Martini Paolo , Barbon Alessandro , Grassi Claudio , Gennarelli Massimo
Published: July 2021

The 3xTg-AD mouse is a widely used model in the study of Alzheimer’s Disease (AD). It has been extensively characterized from both the anatomical and behavioral point of view, but poorly studied at the transcriptomic level. For the first time, we characterize the whole blood transcriptome of the 3xTg-AD mouse at three and six months of age and evaluate how its gene expression is modulated by transcranial direct current stimulation (tDCS). RNA-seq analysis revealed 183 differentially expressed genes (DEGs) that represent a direct signature of the genetic background of the mouse. Moreover, in the 6-month-old 3xTg-AD mice, we observed a high number of DEGs that could represent good peripheral biomarkers of AD symptomatology onset. Finally, tDCS was associated with gene expression changes in the 3xTg-AD, but not in the control mice. In conclusion, this study provides an in-depth molecular characterization of the 3xTg-AD mouse and suggests that blood gene expression can be used to identify new biomarkers of AD progression and treatment effects.
Resveratrol Is a Natural Inhibitor of Human Intestinal Mast Cell Activation and Phosphorylation of Mitochondrial ERK1/2 and STAT3
Authors: Bilotta Sabrina , Paruchuru Lakshmi Bhargavi , Feilhauer Katharina , Köninger Jörg , Lorentz Axel
Published: July 2021

Mast cells play a critical role as main effector cells in allergic and other inflammatory diseases. Usage of anti-inflammatory nutraceuticals could be of interest for affected patients. Resveratrol, a natural polyphenol found in red grapes, is known for its positive properties. Here, we analyzed the effects of resveratrol on FcεRI-mediated activation of mature human mast cells isolated from intestinal tissue (hiMC). Resveratrol inhibited degranulation and expression of cytokines and chemokines such as CXCL8, CCL2, CCL3, CCL4, and TNF-α in a dose-dependent manner. Further, resveratrol inhibited the phosphorylation of extracellular signal-regulated kinase (ERK) 1/2 and signal transducer and activator of transcription (STAT) 3. ERK1/2 is known to be involved in cytokine expression of hiMC and to directly interact with STAT3. Mitochondrial STAT3 is phosphorylated by ERK1/2 and contributes to mast cell degranulation. We were able to isolate mitochondrial fractions from small hiMC numbers and could show that activation of mitochondrial STAT3 and ERK1/2 in hiMC was also inhibited by resveratrol. Our results indicate that resveratrol inhibits hiMC activation by inhibiting the phosphorylation of mitochondrial and nuclear ERK1/2 and STAT3, and it could be considered as an anti-inflammatory nutraceutical in the treatment of mast cell-associated diseases.
Electrochemotherapy and Other Clinical Applications of Electroporation for the Targeted Therapy of Metastatic Melanoma
Authors: Cucu Corina Ioana , Giurcăneanu Călin , Popa Liliana Gabriela , Orzan Olguța Anca , Beiu Cristina , Holban Alina Maria , Grumezescu Alexandru Mihai , Matei Bogdan Mircea , Popescu Marius Nicolae , Căruntu Constantin , Mihai Mara Mădălina
Published: July 2021

Electrochemotherapy (ECT) is an effective bioelectrochemical procedure that uses controlled electrical pulses to facilitate the increase of intracellular concentration of certain substances (electropermeabilization/ reversible electroporation). ECT using antitumor drugs such as bleomycin and cisplatin is a minimally invasive targeted therapy that can be used as an alternative for oncologic patients not eligible for surgery or other standard therapies. Even though ECT is mainly applied as palliative care for metastases, it may also be used for primary tumors that are unresectable due to size and location. Skin neoplasms are the main clinical indication of ECT, the procedure reporting good curative results and high efficiency across all tumor types, including melanoma. In daily practice, there are many cases in which the patient’s quality of life can be significantly improved by a safe procedure such as ECT. Its popularity must be increased because it has a safe profile and minor local adverse reactions. The method can be used by dermatologists, oncologists, and surgeons. The aim of this paper is to review recent literature concerning electrochemotherapy and other clinical applications of electroporation for the targeted therapy of metastatic melanoma.
Calcination of Clay Raw Materials in a Fluidized Bed
Authors: Kaczyńska Katarzyna , Kaczyński Konrad , Pełka Piotr
Published: July 2021

Clay raw materials are diverse in terms of their mineral composition, as well as the content of colouring oxides and their physical properties. Determining the suitability of raw materials for various purposes requires comprehensive studies on their properties, as well as their appropriate correction, which is possible through the use of appropriate modification techniques. One of the most commonly used technologies for the enrichment of clay raw materials is to subject them to high temperatures, which, depending on the temperature regime used in the technological process, may cause the decomposition and removal of some addditional components (e.g., carbonates), as well as the removal of water and dehydroxylation of clay minerals, reversible structural changes, and the complete and permanent reconstruction of the mineral phases. This paper presents a new application for fluidization technology in the calcination of clay raw materials. The results of the experiment show that the fluidization method is competitive compared to the technologies that have been used so far, as a result of, inter alia, the much shorter time period required to carry out the calcination process and, consequently, the much lower energy expenditure, the high efficiency of burning coal, and the lower CO2 emissions resulting from the mixing taking place in the reactor.
Carbon Adsorbents from Spent Coffee for Removal of Methylene Blue and Methyl Orange from Water
Authors: Block Inga , Günter Christina , Duarte Rodrigues Alysson , Paasch Silvia , Hesemann Peter , Taubert Andreas
Published: July 2021

Activated carbons (ACs) were prepared from dried spent coffee (SCD), a biological waste product, to produce adsorbents for methylene blue (MB) and methyl orange (MO) from aqueous solution. Pre-pyrolysis activation of SCD was achieved via treatment of the SCD with aqueous sodium hydroxide solutions at 90 °C. Pyrolysis of the pretreated SCD at 500 °C for 1 h produced powders with typical characteristics of AC suitable and effective for dye adsorption. As an alternative to the rather harsh base treatment, calcium carbonate powder, a very common and abundant resource, was also studied as an activator. Mixtures of SCD and CaCO3 (1:1 w/w) yielded effective ACs for MO and MB removal upon pyrolysis needing only small amounts of AC to clear the solutions. A selectivity of the adsorption process toward anionic (MO) or cationic (MB) dyes was not observed.
Analysis of Multi-Physics Coupling of Small Holes in GH4169 Alloy by Electrolytic Processing of Tube Electrodes
Authors: Li Zhaolong , Dai Ye
Published: July 2021

This paper presents a simulation and experimental study of the structure of small holes in GH4169 alloy electrolytic ally processed by tube electrodes with different characteristic power sources. It analyzes the multi-physical field coupling relationship of flow, temperature, and electric fields within the interstitial space. The results indicate that the tube electrode electrolytic processing of the GH4169 alloy small hole structure with a pulsed power supply has more uniform temperature and current density distribution within the gap, which is beneficial to the processing accuracy and smoothness of the small hole structure. Meanwhile, SEM was used to analyze the microscopic morphology of the electrode end surface during short-circuiting, and it was concluded that as the processing continued, the electrode end surface gradually produced a non-metallic oxide layer, which destroyed the electric field of the gap and affected the processing stability. The use of high-frequency positive and negative pulse power can effectively avoid the generation of a non-metallic oxide layer. Through the combination of simulation analysis and experimental verification, it is concluded that increasing electrolyte pressure in stages can effectively improve machining accuracy and stability. The interstitial current increases as the feed rate of the tool electrode increases, and the diameter of the machined small hole decreases as it increases.
Change in Nutritional Status and Dysphagia after Resection of Head and Neck Cancer
Authors: Sadakane-Sakuramoto Ayumi , Hasegawa Yoko , Sugahara Kazuma , Horii Nobuhide , Saito Syota , Nakao Yuta , Nanto Tomoki , Ono Takahiro , Domen Kazuhisa , Kishimoto Hiromitsu
Published: July 2021

Nutritional status is well-known to influence patient recovery after resection of head and neck cancer (HNC). The influence of preoperative nutritional status on dysphagia was assessed in patients who underwent surgical resection of HNC along with the assessment of nutritional status during the acute and subacute phases. Eighty-six patients underwent surgical resection and dysphagia assessments (repetitive saliva-swallowing test, water-swallowing test, and functional oral intake scale) and had their tongue pressure assessed five times (before surgery, after 1–2 weeks, and 1, 2, and 3 months after surgery). The nutritional status was assessed according to the body mass index, total protein, and albumin. The prognostic nutritional index was calculated from preoperative data, and the subjects were classified into three groups: Low-risk, Attention and High-risk groups. After surgery, the nutritional status index values were low, and the High-risk group showed significantly lower values in comparison to the other two groups. The water-swallowing test and functional oral intake scale findings were worse than they had been preoperatively until 2 months after surgery, and a significant correlation was noted between the postoperative nutritional status and the presence of dysphagia. The results indicated that the preoperative nutritional status of HNC patients influenced their ability to ingest/swallow, which in turn influenced their nutritional status after HNC resection.
Formulation and Optimization of Butenafine-Loaded Topical Nano Lipid Carrier-Based Gel: Characterization, Irritation Study, and Anti-Fungal Activity
Authors: Mahdi Wael A. , Bukhari Sarah I. , Imam Syed Sarim , Alshehri Sultan , Zafar Ameeduzzafar , Yasir Mohd
Published: July 2021

The present study aims to prepare and optimize butenafine hydrochloride NLCs formulation using solid and liquid lipid. The optimized selected BF-NLCopt was further converted into Carbopol-based gel for topical application for the treatment of fungal infection. Box Behnken design was employed to optimize the nanostructure lipids carriers (NLCs) using the lipid content (A), Tween 80 (B), and homogenization cycle (C) as formulation factors at three levels. Their effects were observed on the particle size (Y1) and entrapment efficiency (Y2). The selected formulation was converted into gel and further assessed for gel characterization, drug release, anti-fungal study, irritation study, and stability study. The solid lipid (Compritol 888 ATO), liquid lipid (Labrasol), and surfactant (tween 80) were selected based on maximum solubility. The optimization result showed a particle size of 111 nm with high entrapment efficiency of 86.35% for BF-NLCopt. The optimized BF-NLCopt converted to gel (1% w/v, Carbopol 934) and showed ideal gel evaluation results (drug content 99.45 ± 2.11, pH 6.5 ± 0.2, viscosity 519 ± 1.43 CPs). The drug release study result depicted a prolonged drug release (65.09 ± 4.37%) with high drug permeation 641.37 ± 46.59 µg (32.07 ± 2.32%) than BF conventional gel. The low value of irritation score (0.17) exhibited negligible irritation on the skin after application. The anti-fungal result showed greater efficacy than the BF gel at both time points. The overall conclusion of the results revealed NLCs-based gel of BF as an ideal delivery system to treat the fungal infection.
Timing of Novel Drug 1A-116 to Circadian Rhythms Improves Therapeutic Effects against Glioblastoma
Authors: Trebucq Laura Lucía , Cardama Georgina Alexandra , Lorenzano Menna Pablo , Golombek Diego Andrés , Chiesa Juan José , Marpegan Luciano
Published: July 2021

The Ras homologous family of small guanosine triphosphate-binding enzymes (GTPases) is critical for cell migration and proliferation. The novel drug 1A-116 blocks the interaction site of the Ras-related C3 botulinum toxin substrate 1 (RAC1) GTPase with some of its guanine exchange factors (GEFs), such as T-cell lymphoma invasion and metastasis 1 (TIAM1), inhibiting cell motility and proliferation. Knowledge of circadian regulation of targets can improve chemotherapy in glioblastoma. Thus, circadian regulation in the efficacy of 1A-116 was studied in LN229 human glioblastoma cells and tumor-bearing nude mice. Methods. Wild-type LN229 and BMAL1-deficient (i.e., lacking a functional circadian clock) LN229E1 cells were assessed for rhythms in TIAM1, BMAL1, and period circadian protein homolog 1 (PER1), as well as Tiam1, Bmal1, and Rac1 mRNA levels. The effects of 1A-116 on proliferation, apoptosis, and migration were then assessed upon applying the drug at different circadian times. Finally, 1A-116 was administered to tumor-bearing mice at two different circadian times. Results. In LN229 cells, circadian oscillations were found for BMAL1, PER1, and TIAM1 (mRNA and protein), and for the effects of 1A-116 on proliferation, apoptosis, and migration, which were abolished in LN229E1 cells. Increased survival time was observed in tumor-bearing mice when treated with 1A-116 at the end of the light period (zeitgeber time 12, ZT12) compared either to animals treated at the beginning (ZT3) or with vehicle. Conclusions. These results unveil the circadian modulation in the efficacy of 1A-116, likely through RAC1 pathway rhythmicity, suggesting that a chronopharmacological approach is a feasible strategy to improve glioblastoma treatment.
Are Natural-Based Composites Sustainable?
Authors: Suárez Luis , Castellano Jessica , Díaz Sara , Tcharkhtchi Abbas , Ortega Zaida
Published: July 2021

This paper assesses the aspects related to sustainability of polymer composites, focusing on the two main components of a composite, the matrix and the reinforcement/filler. Most studies analyzed deals with the assessment of the composite performance, but not much attention has been paid to the life cycle assessment (LCA), biodegradation or recyclability of these materials, even in those papers containing the terms “sustainable” (or its derivate words), “green” or “eco”. Many papers claim about the sustainable or renewable character of natural fiber composites, although, again, analysis about recyclability, biodegradation or carbon footprint determination of these materials have not been studied in detail. More studies focusing on the assessment of these composites are needed in order to clarify their potential environmental benefits when compared to other types of composites, which include compounds not obtained from biological resources. LCA methodology has only been applied to some case studies, finding enhanced environmental behavior for natural fiber composites when compared to synthetic ones, also showing the potential benefits of using recycled carbon or glass fibers. Biodegradable composites are considered of lesser interest to recyclable ones, as they allow for a higher profitability of the resources. Finally, it is interesting to highlight the enormous potential of waste as raw material for composite production, both for the matrix and the filler/reinforcement; these have two main benefits: no resources are used for their growth (in the case of biological materials), and fewer residues need to be disposed.
Exploring the Functional Properties of Sodium Phytate Doped Polyaniline Nanofibers Modified FTO Electrodes for High-Performance Binder Free Symmetric Supercapacitors
Authors: Ur Rahman Sami , Röse Philipp , ul Haq Ali Shah Anwar , Krewer Ulrike , Bilal Salma , Farooq Shehna
Published: July 2021

The performance of high-rate supercapacitors requires fine morphological and electrical properties of the electrode. Polyaniline (PANI), as one of the most promising materials for energy storage, shows different behaviour on different substrates. The present study reports on the surface modification of fluorine doped tin oxide (FTO) with the sodium phytate doped PANI without any binder and its utilization as a novel current collector in symmetric supercapacitor devices. The electrochemical behaviour of the sodium phytate doped PANI thin film with and without a binder on fluorine doped tin oxide (FTO) as current collector was investigated by cyclic voltammetry (CV). The electrode without a binder showed higher electrocatalytic efficiency. A symmetrical cell configuration was therefore constructed with the binder-free electrodes. The device showed excellent electrochemical performance with high specific capacities of 550 Fg−1 at 1 Ag−1 and 355 Fg−1 at 40 Ag−1 calculated from galvanostatic discharge curves. The low charge transfer and solution resistances (RCT and RS) of 7.86 Ωcm² and 3.58 × 10−1 Ωcm², respectively, and superior rate capability of 66.9% over a wide current density range of 1 Ag−1 to 40 Ag−1 and excellent cycling stability with 90% of the original capacity over 1000 charge/discharge cycles at 40 Ag−1, indicated it to be an efficient energy storage device. Moreover, the gravimetric energy and power density of the supercapacitor was remarkably high, providing 73.8 Whkg−1 at 500 Wkg−1, respectively. The gravimetric energy density remained stable as the power density increased. It even reached up to 49.4 Whkg−1 at a power density of up to 20 Wkg−1.
Preparation and Performance Evaluation of Antibacterial Melt-Spun Polyurethane Fiber Loaded with Berberine Hydrochloride
Authors: Zhao Ruifang , Tan Pengfei , Han Yanting , Yang Feng , Shi Yidong , Zhu Puxin , Tan Lin
Published: July 2021

(1) Background: Bacterial infections have long threatened global public safety; hence, it is significant to continuously develop antibacterial fibers that are closely related to people’s daily lives. Berberine hydrochloride is a natural antibacterial agent that has application prospects in the preparation of antibacterial fibers. (2) Methods: This study firstly verified the antibacterial properties of berberine hydrochloride and its possible antibacterial mechanism. Thereafter, berberine hydrochloride was introduced into the self-made melt-spun polyurethane fiber through optimized coating technology. The performance of coating modified polyurethane fiber has been systematically evaluated, including its antibacterial properties, mechanical properties, and surface wettability. (3) Results: Results show that the antibacterial polyurethane fiber with desirable comprehensive properties is expected to be used in the biomedical fields. (4) Conclusions: The research also provides a reference for the development and application of other natural antibacterial ingredients in fiber fields.
The Concept of Accuracy Analysis of the Vertical Displacements Gained from the Hydrostatic Levelling Systems’ Measurements
Authors: Kamiński Waldemar
Published: July 2021

Nowadays, hydrostatic levelling is a widely used method for the vertical displacements’ determinations of objects such as bridges, viaducts, wharfs, tunnels, high buildings, historical buildings, special engineering objects (e.g., synchrotron), sports and entertainment halls. The measurements’ sensors implemented in the hydrostatic levelling systems (HLSs) consist of the reference sensor (RS) and sensors located on the controlled points (CPs). The reference sensor is the one that is placed at the point that (in theoretical assumptions) is not a subject to vertical displacements and the displacements of controlled points are determined according to its height. The hydrostatic levelling rule comes from the Bernoulli’s law. While using the Bernoulli’s principle in hydrostatic levelling, the following components have to be taken into account: atmospheric pressure, force of gravity, density of liquid used in sensors places at CPs. The parameters mentioned above are determined with some mean errors that influence on the accuracy assessment of vertical displacements. In the subject’s literature, there are some works describing the individual accuracy analyses of the components mentioned above. In this paper, the author proposes the concept of comprehensive determination of mean error of vertical displacement (of each CPs), calculated from the mean errors’ values of components dedicated for specific HLS. The formulas of covariances’ matrix were derived and they enable to make the accuracy assessment of the calculations’ results. The author also presented the subject of modelling of vertical displacements’ gained values. The dependences, enabling to conduct the statistic tests of received model’s parameters, were implemented. The conducted tests make it possible to verify the correctness of used theoretical models of the examined object treated as the rigid body. The practical analyses were conducted for two simulated variants of sensors’ connections in HLS. Variant no. I is the sensors’ serial connection. Variant no. II relies on the connection of each CPs with the reference sensor. The calculations’ results show that more detailed value estimations of the vertical displacements can be obtained using variant no. II.
A Microcosm Treatability Study for Evaluating Wood Mulch-Based Amendments as Electron Donors for Trichloroethene (TCE) Reductive Dechlorination
Authors: Masut Edoardo , Battaglia Alessandro , Ferioli Luca , Legnani Anna , Cruz Viggi Carolina , Tucci Matteo , Resitano Marco , Milani Alessandro , de Laurentiis Camilla , Matturro Bruna , Di Franca Maria Letizia , Rossetti Simona , Aulenta Federico
Published: July 2021

In this study, wood mulch-based amendments were tested in a bench-scale microcosm experiment in order to assess the treatability of saturated soils and groundwater from an industrial site contaminated by chlorinated ethenes. Wood mulch was tested alone as the only electron donor in order to assess its potential for stimulating the biological reductive dechlorination. It was also tested in combination with millimetric iron filings in order to assess the ability of the additive to accelerate/improve the bioremediation process. The efficacy of the selected amendments was compared with that of unamended control microcosms. The results demonstrated that wood mulch is an effective natural and low-cost electron donor to stimulate the complete reductive dechlorination of chlorinated solvents to ethene. Being a side-product of the wood industry, mulch can be used in environmental remediation, an approach which perfectly fits the principles of circular economy and addresses the compelling needs of a sustainable and low environmental impact remediation. The efficacy of mulch was further improved by the co-presence of iron filings, which accelerated the conversion of vinyl chloride into the ethene by increasing the H2 availability rather than by catalyzing the direct abiotic dechlorination of contaminants. Chemical analyses were corroborated by biomolecular assays, which confirmed the stimulatory effect of the selected amendments on the abundance of Dehalococcoides mccartyi and related reductive dehalogenase genes. Overall, this paper further highlights the application potential and environmental sustainability of wood mulch-based amendments as low-cost electron donors for the biological treatment of chlorinated ethenes.
Імплементація концепту глокального міста як вектор розвитку малих міст України
Authors: Бабич О.
Published: July 2021

Окреслено алгоритм практичного застосування концепту глокального міста як вектора розвитку малих міст України. Розкрито сутність та переваги, які відкриває глокалізаціїя для малих міст, та визначено, якими повинні бути кроки органів місцевого самоврядування на шляху до перетворення міста у глокальне. Визначено, що конкурс “Малі міста – великі враження” можна вважати одним із перших кроків на шляху до імплементації концепту глокального міста на вітчизняних теренах.
Проблеми та перспективи розвитку інклюзивної освіти в Україні
Authors: Крилошанська Л. , Ундір В.
Published: July 2021

Розглянуто особливості запровадження інклюзивної освіти в Україні в контексті євроінтеграції. Проаналізовано динаміку реалізації інклюзивного навчання в контексті реформи системи освіти. Розглянуто складові підготовки системи освіти до реалізації процесу інклюзії як для педагогів, так і для дітей з особливими освітніми потребами та основні проблеми формування освітнього середовища.
Цифрові інструменти забезпечення сталого розвитку
Authors: Бліщук К. , Домша О.
Published: July 2021

Розглянуто особливості використання цифрових інструментів відповідно до потреб забезпечення сталого розвитку в суспільстві. Вивчено специфіку застосування цифрових інструментів у різних сферах життєдіяльності суспільства. Проаналізовано еволюцію розвитку цифрових інструментів у світі протягом останніх двадцяти років. Представлено напрями активізації застосування цифрових інструментів забезпечення сталого розвитку на сучасному етапі трансформаційних змін в Україні.
Utopia sabática: Adorno e o capitalismo como religião
Authors: Santos Jéverton Soares dos
Published: July 2021

Este texto faz parte dos esforços do autor de empreender uma hermenêutica messiânica do pensamento de Theodor Adorno. Assim sendo, o objeto deste artigo é o mote do capitalismo como religião que aparece de uma forma marginal no interior da tradição do marxismo ocidental e que foi, recentemente,  rearticulado pela pesquisa seminal de Michael Löwy.  Para isso, este artigo procurou resgatar alguns motivos messiânicos de História e Consciência de Classe (Introdução). Feito isso, almejou-se mostrar como Adorno procurou cobrir as lacunas filosóficas da obra de Lukács a partir da noção de reconciliação (Seção 1). A seguir, mostrou-se como a Minima Moralia faz uma crítica intra e extratextual à hipóstase do trabalho como redenção, oriunda de uma tradição teológica que remonta à divinização do sofrimento cujo paradigma é a Magna Moralia, obra patrística sobre a personagem bíblica de Jó (Seção 2). Assim, constatou-se que várias observações adornianas sobre o caráter infernal do capitalismo coincidem com as atuais – e não menos perturbadoras – reflexões do filósofo germano-coreano Byung-Chul Han e sua caracterização da sociedade neoliberal como uma sociedade do cansaço não-redentor (Seção 3). Sendo assim, demonstrar-se-á como o ensejo utópico de uma sociedade-sem-trabalho, resgatado de forma brilhante por Han, corresponde com as aspirações da filosofia da redenção de Adorno (Seção 4). Por último, a partir do paradigma judaico do “Shabat”, analisar-se-á a defesa de Han e Adorno de uma utopia sabática como protótipo do fim do capitalismo como religião (Seção 5).

 

Palavras-chave: capitalismo como religião; reconciliação; trabalho; utopia sabática;
Filosofia, literatura e descrença no Diálogo entre um Padre e um Moribundo do Marquês de Sade
Authors: Primo Marcelo de Sant'Anna Alves
Published: July 2021

Que Sade foi um filósofo, literato e ateu não se tem a menor dúvida. Nesse sentido, o objetivo do presente artigo é mostrar como se articulam as três facetas supracitadas do marquês na leitura do seu texto inaugural Diálogo entre um padre e um moribundo, de 1782. Através do estilo e estrutura clássicos do diálogo, o escritor desfere contundentes ataques, ambientado em uma alcova, resultando em: 1) a crítica à exploração do medo nos homens pelos cristãos no momento da morte; 2) e, consequentemente, recusa a existência de deus quando opõe a razão e os sentidos às quimeras religiosas. Contudo, Sade vai muito mais além do que usar a arte do diálogo filosófico para encarar tête-à-tête os dogmas da religião: a defesa de uma postura serena diante da morte não significa ficar somente no plano do discurso, já que o subverte introduzindo a ação em vez de explicar através de conceitos o que seria a natureza corrompida do homem. Logo, podemos concluir que o Diálogo passa dos limites de uma simples manifestação literária do materialismo ateu sadeano sendo, na verdade, um autêntico escrito de resistência que, tendo como marco inicial o desamparo do homem, afirma o corpo para superá-lo explorando os prazeres corporais ao extremo.

Palavras-chave: Sade. Filosofia. Literatura. Ateísmo.
Lugares Matemáticos em Contos de Malba Tahan
Authors: Zwiernik Luara , Dalcin Andreia
Published: July 2021

Malba Tahan é um personagem-autor que ficou famoso por seus contos ambientados em cenários árabes, muitos deles apresentam elementos matemáticos, o que o torna um dos primeiros escritores brasileiros a aproximar Literatura e Matemática. Neste artigo analisamos quatro contos: O conto dos camelos; O conto das irmãs e da venda das maçãs; O conto da verdade e da mentira; e O conto da divisão do reino, localizados nos livros O livro de Aladim, 1ª edição, e O homem que calculava, 8ª edição, ambos publicado em 1943 pela editora Getúlio Costa. A questão que norteou o processo de análise dos contos é como e quais elementos matemáticos emergem e são abordados em contos de Malba Tahan? No processo de análise procurou-se identificar e compreender que elementos matemáticos aparecem nos textos de forma explícita ou implícita, ou seja, que lugares matemáticos emergem na construção das narrativas, com o intuito de melhor compreender a articulação entre literatura e matemática que caracterizam tais textos.
INCREASING THE COMPETITIVENESS OF THE TIMBER INDUSTRY COMPLEX BY MEANS OF INNOVATIVE DEVELOPMENT
Authors: Butko Galina , Yakovenko Nataliya
Published: July 2021

Management of the competitiveness of the regional forestry sector is defined by social, economic, environmental, institutional and other factors as an impact on the regional forestry sector and its actors in order to create and strengthen competitive advantages in the domestic and foreign markets, to maintain the integrity and sustainable development of the sector, reflected in the indicators that characterise the state of competitiveness. The availability and condition of forest capital is studied on a time-discounting basis, taking into account factors such as forest maturity and logging turnover. Based on the strategic level of forest capital competitiveness, the degree of implementation of the forest capital competitiveness strategy is determined in two ways: a) forest capital competitiveness based on traditional technologies; b) forest capital competitiveness based on innovations. To assess the competitiveness of forest capital, it is proposed to use the indicator "Estimated incremental value of forestry capital". In the authors' opinion, the calculation of this indicator should be defined as the ratio of financial flow in the form of the sum of net profit and depreciation to the value of assets. The proposed author's approach makes it possible to estimate innovation resources, the application of which will make it possible to identify priority areas of innovative growth of the timber industry complex and select priority areas of its innovative development.
Teacher Applicants' Self-Efficacy and English Proficiency
Authors: Dungog Vanesa B. , Libo-on Joefel T.
Published: July 2021

Self-efficacy is a belief in one capability in accomplishing a particular task. Most of the related studies concluded that having a high self-efficacy has something to do with high performance at work. It has something to do with an individuals' work output/ production; however, some other literature revealed that it does not have something to do with an individual's performance. On the other side, the English language is the required medium of instruction yet the most feared. This study investigated the self-efficacy towards the English Proficiency Test of the teacher applicants from the Division of Romblon. Findings showed that respondents have Low Self- efficacy status towards English Proficiency Test. It concluded that proficient respondents have a Very Low Self-efficacy among the levels of English Proficiency compared to other levels that reached the Low level. Further, the overall English Proficiency of teacher applicants was at the Beginners level.
A Study of the Duration of Controlled Speech in Right Hemisphere of the Brain Damaged Male Participants
Authors:   Department of English Language and Linguistics, Adamas University, Barasat, Kolkata, West Bengal 700126, India., Pal Agniva
Published: July 2021

This is a neuro-linguistic research which compares Bangla speaking right hemisphere damaged (furthermore to be called RHD) male participants to age and gender matched normal males who have been selected from the same family as the right hemisphere damaged participants. RHD or right hemisphere damaged participants are those who have lesions or damages in the right hemisphere of the brain or both. This paper pertains to the understanding how a lesion or a damage in the right hemisphere can cause changes in the pattern of communication of adult males in the age group of 45 to 70. This paper discerns the difference in durations of controlled speech in RHD males compared to age and gender matched normal controls. It will be measured with the help a predetermined passage. A passage will be played to them, using a media player (to make sure everyone listens to the same recording, ruling out chances of error there) and then they will be asked to repeat the same passage, as much as they can remember. In this research, we will be looking at the time they would take to narrate the whole passage without missing out on anything.
PV Module Parameters Estimation Using Newton Raphson
Authors: Dharmarajan Ranjith , Ramachandran Rajeswari
Published: July 2021

The estimation of solar photovoltaic (PV) system with help of electrical model parameters, such as photon generated current, the diode saturation current, series resistance, shunt resistance, and diode ideality factor, are desirable to predict the real performance characteristics of solar PV under varying environmental conditions. Finally, performance indices, such as PV characteristics curve are estimated for the various solar PV panels, using Newton Raphson (NR) to reveal the effectiveness of the proposed method. Also, validation with `experimental data has been considered. Finally, through the comparative analysis of the results, it is revealed that the proposed method offers solar PV characteristics closer to the real characteristics.
Analisa Perbaikan Tata Letak Penempatan Bahan Bakudi Area Gudang Penyimpanan
Authors: Harma Beni , Sudra Helga Ika
Published: July 2021

Activities carried out in the warehouse include material handling. Generally, the costs involved in material handling activities are quite large. One method that can be used in managing the layout of raw material placement in raw material warehouses is the class based storage method. Class based storage is a policy that divides storage into three classes A, B and C based on Pareto law. Pareto law is the principle of putting items that have the greatest accessibility near the Input-Output point. The distance of material handling to the initial layout raw material warehouse is 3,513,337 meters / month and the material handling costs are Rp. 134,534,765 / month, because the initial layout of the raw material warehouse still uses random storage and the raw materials that are widely used are not placed close to the intake floor of the production, so that the distance to get raw materials for production needs is far. After the re-layout design was made based on the placement of raw materials in the class based storage method, the material handling transfer distance was reduced to 2,644,459 meters / month and the material handling cost for the repair raw material warehouse layout fell to Rp. 99,949,520 / month. In other words, there was a decrease in material handling distance by 25% and material handling costs by 26%.
Penerapan Metode Weighted Product dalam Memperdiksi Permintaan Konsumen di Salon Mobil Singgalang Motor
Authors: Shary Armonitha Lusinia  , Heri Yanto  , Mardi Saputra
Published: July 2021

Semakin banyaknya mobil-mobil berharga murah maka semakin banyak orang yang memiliki mobil, sehingga jasa perawatan mobil pun semakin banyak dibutuhkan. Pada mobil, proses perawatan ini melingkupi bagian eksterior, bagian interior hingga ke celah-celah tersempit, hingga ke bagian mesin. Karena prosesnya yang detail dan rumit serta untuk memuaskan konsumen, maka sebaiknya digunakan sebuah sistem pendukung keputusan untuk membantu memprediksi minat konsumen. Sistem pendukung keputusan dibangun untuk mendukung solusi atas suatu masalah atau untuk mengevaluasi suatu peluang. Sistem pendukung keputusan seperti itu disebut aplikasi sistem pendukung keputusan. Sistem pendukung keputusan dapat diterapkan dengan metode Weigthted Product. Metode Weigthted Product hasil pengujian fungsionalitas memiliki kinerja sistem yang dapat berjalan sesuai dengan kebutuhan fungsional dan hasil pengujian validitas berdasarkan perbandingan perhitungan manual perusahaan dengan perhitungan aplikasi web. Sistem pendukung keputusan dengan menggunakan metode Weigthted Product dapat membantu para pengambil keputusan dalam prediksi minat konsumen pada Singgalang Motor. Serta deengan menerapkan bahasa pemrograman PHP dan didukung dengan database MySQL pada perancangan sistem pendukung keputusan maka akan dengan mudah, cepat dan lebih efisien dalam menentukan keputusan dan dapat memudahkan Singgalang Motor dalam prediksi minat konsumen dan lebih tepat sasaran.
Analisis Quality Control dalam Proses Pengolahan Teh Hitam dengan Metode Six Sigma
Authors: Irsan
Published: July 2021

PT.Perkebunan Nusantara VI Unit Usaha Danau Kembar yang merupakan salah satu perusahaan Badan Usaha Milik Negara yang bergerak dibidang industriperkebunantehhitam.Penelitianinibertujuanuntukmenganalisakualitasprosespengolahantehhitamyangmenyimpang(cacat)ataureworkpadastasiunkerjapengeringandenganmenggunakanmetodepengendaliankualitasSixSigmamelaluikonsepDMAIC.HasilpenelitianinimenunjukanbahwanilaisigmayangdidapatkanuntukproduksitehhitamjenisPF(PeccoFanning)memilikinilaisigma3,2661(3sigma)dengannilaiDPMOsebesar38690.Halinimenunjukkanbahwasetiapsatujutakesempatanakanterdapatkemungkinan38690unitketidaksesuian/produkrework.Penyebabrewokpadaprodukdipengaruhiolehfaktormanusia,mesin,lingkungankerjasertametodekerjayangdilakukan.
Expert System Untuk Acupressure Dengan Metode Backward Chaining
Authors: Ratih Purwasih
Published: July 2021

Acupressure or in other words called reflexology is a way of treating the disease through nerve center points associated with certain organs. In other words, healing is a disease through nerve massage to improve blood circulation. With the design of an expert acupressure system using foot massage created to help detect health problems experienced by someone by providing therapeutic solutions using foot reflexology in the form of graphics that must be massaged by the user without having to wait for help from people who are experts in their fields. The design of this system uses Backward Chaining inference, with the implementation of the system using the MySQL database system and Visual Basicprogram. From the system design that is made, it can be obtained a point massage solution that must be treated based on the symptoms felt.
Organization & Methods yang Membedakan Efektivitas Manajemen Koperasi Simpan Pinjam Karya Berkah
Authors: Rubianto Pitoyo
Published: July 2021

Penelitian ini bertujuan untuk mengetahui apakah terdapat hubungan variabel organization and methods dan variabel efektivitas manajemen Koperasi Simpan Pinjam Karya Berkah, dan variabel organization and methods manakah yang mampu membedakan variabel efektivitas manajemen Koperasi Simpan Pinjam Karya Berkah. Penelitian ini terdiri dari 8 (delapan) variabel independen dari ruang lingkup organization and methods yaitu komunikasi dalam organisasi (X1), tata kerja, prosedur kerja dan sistem kerja (X2), filing dan formulir (X3), mesin dan otomatisasi (X4), peralatan kantor (X5), tata ruang dan perencanaan penyusunan ruangan (X6), penulisan laporan (X7), anggaran (X8) dan variabel dependen yaitu efektivitas manajemen Koperasi Simpan Pinjam Karya Berkah (Y). Desain penelitian ini adalah deskriptif dan cross sectional. Untuk memperoleh instrumen yang valid dan reliable dilakukan uji validitas dan uji reliabilitas. Teknik analisa data dengan menggunakan analisa chi-square dan analisa diskriminant. Hasil penelitian menunjukkan bahwa: hubungan variabel organization and methods yang mempunyai hubungan signifikan dengan efektivitas manajemen Koperasi Simpan Pinjam Karya Berkah ada 3 variabel yaitu, variabel filing dan formulir, variabel mesin, dan variabel peralatan. Dari 3 variabel yang digunakan untuk pendekatan, hanya variabel mesin yang bisa digunakan untuk analisa diskriminant, berarti hanya variabel mesin mampu membedakan efektif atau tidak efektifnya manajemen Koperasi Simpan Pinjam Karya Berkah.
Analisis Status Gizi Siswi Sekolah Dasar di Kenagarian Air Bangis Kabupaten Pasaman Barat
Authors: Sefri Hardiansyah
Published: July 2021

Permasalahan dalam penelitian ini adalah kurangnya aktivitas gerak yang dilakukan oleh para siswi dalam pelaksanaan pembelajaran Penjasorkes pada tingkat Sekolah Dasar di Kenagarian Air Bangis Kabupaten Pasaman Barat. Kurangnya aktivitas gerak dalam pelaksanaan pembelajaran Penjasorkes tersebut kemungkinan disebabkan oleh rendahnya status gizi siswa. Penelitian ini termasuk penelitian deskriptif yang bertujuan untuk mengetahui tingkat status gizi siswi di Sekolah Dasar yang berada di Kenagarian Air Bangis Kabupaten Pasaman Barat. Populasi dalam penelitian ini adalah seluruh siswa kelas IV dan V Sekolah Dasar kelas yang ada di Kenagarian Air Bangis Kabupaten Pasaman Barat dengan jumlah 168 orang yang terdiri dari 7 Sekolah Dasar. Teknik penarikan sampel dengan menggunakan teknik purposive sampling sehingga sampel dalam penelitian ini berjumlah 59 orang. Data dikumpul melalui pengukuran berat badan dan tinggi badan dan menggunakan rumus Indeks Masa Tubuh (IMT). Data dianalisis dengan menggunakan rumus persentase. Dari hasil penelitian dapat diketahui bahwa sebagian besar status gizi siswi sekolah dasar di Kenagarian Air Bangis Kabupaten Pasaman Barat berada pada kategori normal dengan jumlah siswa sebanyak 46 orang dengan persentase sebesar 77.97%.
Sistem Informasi Pemesanan Jasa Wedding Organizer pada Youzhie Penganten dengan Menggunakan Bahasa Pemograman PHP Dan MySQL
Authors: Vicky Ariandi
Published: July 2021

Web design Ordering Wedding Organizer Services at Youzhie Bride aims to make it easier for the public to obtain information on ordering wedding services (online) that were previously known from the mouth of the mouth so that they can save time, here I make it easier for people to order online so they can be efficient and effective . This final project can help in building an online ordering system. The design system in making websites Ordering Wedding Organizer Services at Youzhie The bride was developed using several software namely xampp, Notepad ++, Server which is a combination of Web Server, PHP and MySQL
Analisis Postur Kerja Karyawan di bagian Pengangkatan Bahan Baku dengan Menggunakan Metode Owas (Ovako Working Posture Analysis) dan Rula (Rapid Upper Limb Asessement) di PT.Sumatera Tropical Spices
Authors: Robino Indan  , Nila Kusuma Pratiwi  , Mufrida Meri.Z
Published: July 2021

Penggunaan tenaga manusia sebagai pekerja sangatlah dominan terutama kegiatan penanganan material secara manual (Manual Material Handling). PT.SUMATERA TROPICAL SPICES mengolah rempah-rempah menjadi bumbu masak dan penyedap masakan yaitu kulit kayu manis, untuk bagian pembongkaran bahan baku mentah mereka masih menggunakan tenaga manusia sebagai alat pemindahan barang dari truk pengangkut bahan baku menuju gudang yang mana sangat memungkin terjadinya Musculoskeletal Disorders, Untuk mengetahui tingkat resiko cedera pada pekerja dan keluhan nya makadi analisis dengan menggunakan metode OWAS (Ovako Working Posture Analysis) dan metode RULA (Rapid Upper Limb Asessement).Data penelitian di dapatkan menggunakan kuesioner dengan jumlah responden sebanyak 13 orang dan foto pekerja yang sedang mengangkat dan menurunkan bahan baku. Untuk kategori resiko OWAS terdapat 5 posisi yang sangat tinggi Sedangkan untuk kategori resiko RULA yang bernilai 3 dan 4 menghasilkan tingkat kategori resiko sedang dan tindakan yang harus.