bluuebunny/crossref_metadata_2025 huggingface dataset:
Successful sequential extracorporeal multiple organ support therapy in COVID-19 pneumonia: A case report
Authors:   Internal Medicine, Christus Muguerza, Universidad de Monterrey, Monterrey, Nuevo León, México., Villasana Salazar Cynthia Estefanía
Published: March 2022

Patients with severe COVID-19 pneumonia can develop acute respiratory distress syndrome, which triggers respiratory failure. Multiple Organ Support Therapies (MOST), such as Extra Corporeal Membrane Oxygenation (ECMO), Continuous Renal Replacement Therapy (CRRT) or plasmapheresis, can be used as part of adjunctive management in patients with refractory hypoxemia even with the appropriate use of optimal mechanical ventilation and pharmacological measures. We describe a case of a 31-year-old man who, upon admission, is managed with mechanical ventilation and due to poor evolution, it is decided to start ECMO therapy within the first 24 hours of admission; subsequently, management with CRRT with oXiris filter and plasmapheresis is initiated in the first three days of hospitalization. The patient presents a rapid clinical improvement and a significant decrease in inflammatory markers. CRRT with oXiris filter has been associated with a significant reduction in cytokine and endotoxin levels; while plasmapheresis therapy also eliminates inflammatory mediators. Management with ECMO has shown benefits as salvage therapy in patients with hypoxemia. The success of these cases depends largely on the early onset of ECOS in the critically ill patient.
Amidst the chaos of late rheumatoid arthritis with no treatment
Authors:   Department of Internal Medicine, Division of Rheumatology, Shiraz University of Medical Sciences, Shiraz, Iran., Shenavandeh Saeedeh , Sefidbakht Sepideh ,   Department of Radiology, Shiraz University of Medical Sciences, Shiraz, Iran.
Published: March 2022

A 78-year-old man with 24 years history of Rheumatoid Arthritis (RA) came with neck pain. He always refused any treatment except for NSAIDs. From 2 years ago, he was bedridden. He was chronic cigarette smoker. On examination, he had rheumatoid nodules, severe both hands deformity, elbows flexion contracture and knee joints limitation of motion. His lab tests showed high titer of rheumatoid factor and anti cyclic citrullinated protein antibody, high ESR, CRP and vitamin D deficiency. Radiologic studies showed multiple vertebral osteoporotic fractures. Cervical spine CT scan (a and b) showed destruction of the odontoid process and fusion of facet joints of the C2, C3 and C4. MRI of cervical spine (c) showed destruction of odontoid process surrounding by inflammatory synovitis. CT scan of lung (e and f) showed multiple upper lobeand sub pleural nodules along fibrotic changes in base of right lobe. X-ray of knee and hip (d and g) showed severe osteoarthritis andsite of previouship nailing. The patient was diagnosed with advanced erosive nodular RA, severe secondary osteoporosis, osteoarthritis and rheumatoid lung. Standard treatment was recommended, although he again refused. RA can result in progressive joint destruction, deformity and disability [1]. In the spine, it has a predilection for the cervical area, leads to odontoid erosion, spinal instability, and subluxation. In the era of importance of early treatment, these complications are rarely seen, however despite biologic therapy, it has been shown that 15-30% of RA patients can still have preclinical cervical spine abnormalities [2]. The Osteoporosis (OP) is more frequent in patients with high disease activity, bone erosions, >10 years disease duration, and high titers of anti-CCP and RF positivity [3]. Our patient with multiple poor prognostic factors for erosive RA came with extra articular and complications of this disease due refusing treatment.
Desminopathy with early cardiac involvement mimicking apical hypertrophic cardiomyopathy: Demonstration by cardiovascular magnetic resonance
Authors:   Center for Cardiovascular MRI, University of Ottawa Heart Institute, Ottawa, Canada., Tavoosi Anahita , Chenier Sophie ,   Center for Cardiovascular MRI, University of Ottawa Heart Institute, Ottawa, Canada., Ghosh Nina ,   Center for Cardiovascular MRI, University of Ottawa Heart Institute, Ottawa, Canada., Lamacie Mariana M ,   Center for Cardiovascular MRI, University of Ottawa Heart Institute, Ottawa, Canada., Crean Andrew M ,   Center for Cardiovascular MRI, University of Ottawa Heart Institute, Ottawa, Canada.
Published: March 2022

We present a report of a patient with desmin-related skeletal myopathy who underwent Cardiac MRI (CMR) following episodes of palpitations. Despite a recent normal echocardiogram, the CMR study revealed mild but unequivocal apical hypertrophy. These appearances were indistinguishable from those seen with sarcomeric apical hypertrophic cardiomyopathy. This case adds desminopathy to the growing list of potential HCM phenocopies and should be considered in situations where skeletal muscular weakness has also been identified.
Pemetrexed-cisplatin combined with antiangiogenesis drug in recurrent and metastatic cervical carcinoma: A case report and literature review
Authors:   Department of Radiation and Medical Oncology, Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan, China., Yang Hui , Mei Zijie ,   Department of Radiation and Medical Oncology, Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan, China., Sun Shaoxing ,   Department of Radiation and Medical Oncology, Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan, China., Qiu Hui ,   Department of Radiation and Medical Oncology, Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan, China.
Published: March 2022

Pemetrexed is an antifolate agent which has shown activity on various tumors. But no result has been reported on the clinical efficacy and toxicity of pemetrexed combined with antiangiogenesis drug in patients with cervical cancer. Apatinib is an oral antiangiogenesis drug in cervical cancer, which has been reported efficacy and safety in cervical cancer. Here, we present a 50-year-old woman who was diagnosed with recurrent and metastatic cervical adenocarcinoma two years after postoperative adjuvant radiotherapy. After pathology and magnetic resonance imaging confirmed the recurrence and metastasis, the patient was administered pemetrexed 500 mg/m2 and cisplatin 50 mg/m2 on day 1, cycled every three weeks for four cycles. Then add apatinib 500 mg/d from day 1 to day 21 combined with pemetrexed and cisplatin for two cycles, followed by pemetrexed 500 mg/m2 on day 1 combined with apatinib every 21 days per cycle for two cycles. Finally, a single dose of apatinib is a maintenance therapy. According to the Response Evaluation Criteria In Solid Tumors (RECIST) 1.1 standard, she was confirmed as Partial Response (PR). Now, the Progression-Free Survival (PFS) of the patient has been 21 months. No grade III-IV adverse effects have been found. In conclusion, pemetrexed-cisplatin combined with antiangiogenesis drug might be an effective and mild toxic treatment for patients with recurrent or metastatic cervical carcinoma. Further prospective clinical trials are needed to verify this conclusion.
Amniotic band sequence
Authors:   Pediatrics Department, Centro Hospitalar de Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal., Lira Joana , Pereira Isabel Ayres ,   Pediatrics Department, Centro Hospitalar de Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal., Reis Joana Soares ,   Pediatrics Department, Centro Hospitalar de Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal., Amaral Marina ,   Pediatric Surgery Department, Centro Hospitalar de Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal., Gomes Anabela ,   Neonatology Unit, Pediatrics Department, Centro Hospitalar de Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal.
Published: March 2022

A 33 weeks preterm female weighting 1945 g was born to a 28-year-old gravida 2 para 1. Pregnancy was surveilled in Angola with two ultrasounds performed at 12 and 23 weeks reported as normal. Emergent cesarean section was performed due to severe fetal bradycardia in context of a maternal sepsis. She was born depressed and was immediately intubated, with good response (AS 2/5/7) being off mechanical ventilation 1 hour later. Her clinical examination revealed multiple distal deformities in all the four limbs (Figures 1-3), being possible to observe syndactyly and amputation phenomena. Small constricting strings were visible, attached to the distal extremities. At day 1 she was observed by a pediatric surgeon that excised the constricting bands in some of the fingers. She was discharged from the hospital at day 24 and at her 3 months’ appointment she had a normal development and maintained her surveillance by a multidisciplinary team that includes an orthopedic surgeon.
Acute hepatic porphyria attack following mini gastric bypass surgery
Authors:   Israeli Porphyria Center, Rabin Medical Center, Petach Tikva, Israel., Edel Yonatan , Kharouf Fadi ,   Department of Medicine, Rheumatology Unit, Hebrew University-Hadassah Medical Center, Jerusalem, Israel., Levi Assi ,   Sackler Faculty of Medicine, Tel Aviv University Tel Aviv, Israel., Cohen Sharon ,   Israeli Porphyria Center, Rabin Medical Center, Petach Tikva, Israel., Noy Ariel ,   Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel., Goldwicht Natalie ,   Department of Genetics, Hebrew University-Hadassah Medical Center, Jerusalem, Israel., Mamet Rivka ,   Israeli Porphyria Center, Rabin Medical Center, Petach Tikva, Israel.
Published: March 2022

Acute Intermittent Porphyria, (AIP) is a rare disease caused by Hydroxymethylbilane Synthase (HMBS) deficiency. It is characterized by acute neurovisceral attacks, in which excessive heme production is induced following exposure to a trigger. One of the suggested triggers is low carbohydrate intake. We report a 32-year-old female who suffered from severe abdominal pain, nausea and general weakness following a bariatric mini gastric bypass surgery. There was a positive family history of AIP, but the patient had a normal Porphobilinogen urine test as a child, therefore diagnosis was not made. During current symptoms, urinary porphobilinogen was highly increased and AIP was diagnosed. Treatment with IV dextrose and Heme Arginate alleviated the patient’s symptoms. After discharge, Family genetic testing revealed a novel pathogenic mutation in the HMBS gene. Had genetic testing been performed earlier, diagnosis of AIP could have been established earlier. Early diagnosis may prevent attacks and reduce their severity. Since a bariatric surgery leads to low intake of carbohydrates, it might be an indirect trigger of an acute porphyria attack. Keywords: porphyria; bariatric surgery; porphobilinogen.
A case report of thrombocytopenia induced by sodium valproate sustained release tablets in a schizophrenic patient
Authors:   Department of Otolaryngology, Charring Cross Hospital, Imperial College Healthcare NHS Trust, London, UK., Xiong Qiang , Wang Yingchan ,   Shanghai Mental Health Center, 600 Wanping South Road, Xuhui District, Shanghai, China.
Published: March 2022

The patient, a 28-year-old female, was aggravated by suspicion for more than a year, and the total course of the disease was unknown. She was sent to the outpatient clinic of our hospital by the staff of the rescue station on December 20, 2020. Outpatient clinic with “schizophrenia?” Admitted to hospital. Psychiatric examination after admission found that patients had obvious victim delusion, absurd content, the object was generalized, and the patient firmly believed it. No obvious abnormalities were found in admission physical examination. The patient denied the history of severe somatic disease, drug allergy and infection. Deny taking any drugs recently. No obvious abnormalities were found in the blood routine examination, liver and kidney function, electrolyte, blood glucose, blood lipid, thyroxine, stool routine, infectious diseases (5 markers of hepatitis B, hepatitis C, syphilis, HIV antibody), electrocardiogram, electroencephalogram, chest CT, abdominal color ultrasound and so on. PANSS score 81. According to ICD-10 diagnostic criteria, schizophrenia was diagnosed after admission, and aripiprazole was given antipsychotic treatment. The initial dose was 10 mg/day, and increased to 20 mg/day after 3 days and maintained until discharge. On January 10, 2021, the patient developed impulsive behavior and was treated with sodium valproate sustained-release tablets (VAP) 500 mg/day to stabilize emotion. The effective concentration of drug treatment was 50-100 μg/mL [1]. During the follow-up of 7 February 2021, the platelet count of the patients was decreased, and the platelet count was 82 X 109 /L Considering the adverse drug reactions caused by VAP, VAP was stopped immediately on the same day. On February 16,2021, routine blood platelet count showed that it returned to normal. After March 10,2021, the platelet was in the normal range, and further increased compared with February 16 (See Table 1).
Delayed metastatic melanoma to the pharyngeal tonsil in a Chinese male
Authors:   Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Chengdu Medical College, Sichuan, China., Zhou Yulin , Huang Zhen Cheng ,   XinDu Hospital of Tradional Medical, China., Wang Yi ,   Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Chengdu Medical College, Sichuan, China.
Published: March 2022

Background: Melanoma is a relatively uncommon malignant neoplasm, either primary or secondary. We present a case of delayed metastatic melanoma to the pharyngeal tonsil. Case report: A 70-year-old Chinese male presented for half a year due to vague speech and snoring and then found tonsil enlargement. Three years prior to presentation, he had undergone primary resection and systemic therapy for cutaneous melanoma on the sole of his foot. Tonsil biopsy confirmed the diagnosis of metastatic melanoma. Currently the patient is undergoing chemotherapy. Conclusion: Metastatic melanoma is a rare disease, and metastatic lesions may occur at any location. For the long-term survival of patients, careful examination should be done during the follow-up period, including head and neck. Keywords: metastatic melanoma; tonsillar neoplasms.
Carotid angioplasty and stenting-Device related complication: Embolic protection filter-wire retention
Authors:   Department of Neurology, All India Institute of Medical Sciences, New Delhi, India., Elavarasi Arunmozhimaran , K Narayan Sunil ,   Department of Neurology, Jawaharlal Institute of Postgraduate Medical Education and Research, India., K Nagarajan ,   Department of Radiodiagnosis, Jawaharlal Institute of Postgraduate Medical Education and Research, India.
Published: March 2022

Carotid stenting with the use of an embolic protection device has become a common procedure done routinely for carotid stenosis. The procedure is usually done in patients with transient ischemic attacks or minor strokes for preventing further strokes. Since it is done on patients who are asymptomatic or minimally symptomatic, the occurrence of complications should be kept as close to nil. It is important to know potential complications to be careful when we subject patients to such interventions which can be rewarding if they go well but can be devastating if things go wrong. Here we present a case of carotid stenosis who underwent successful stenting however had a retained filter wire of the embolic protection device. The patient was managed conservatively and the need for a major surgical procedure to remove the retained device could be avoided.
Renal cell carcinoma with leiomyomatous stroma: A case report and a review of the literature of a provisional entity distinct from conventional renal cell carcinoma
Authors:   Department of Pathology, Ohio State University Wexner Medical Center, James Cancer Hospital and Richard Solove Research Institute, Columbus, OH USA., Chaudhry Nermeen , Shaker Nada ,   Department of Pathology, Ohio State University Wexner Medical Center, James Cancer Hospital and Richard Solove Research Institute, Columbus, OH USA., Karera Monika ,   Department of Pathology, Ohio State University Wexner Medical Center, James Cancer Hospital and Richard Solove Research Institute, Columbus, OH USA., Parwani Anil ,   Department of Pathology, Ohio State University Wexner Medical Center, James Cancer Hospital and Richard Solove Research Institute, Columbus, OH USA.
Published: March 2022

Renal Cell Carcinoma with Leiomyomatous Stroma (RCCLMS) is a rare renal cancer with indolent behavior and favorable prognosis. We present a case of rare renal cell carcinoma with leiomyomatous stroma in a 49-year-old male, with an incidental finding of a 1.6 cm renal nodule on MRI scan. The patient underwent partial nephrectomy of the left kidney and subsequent histological examination showed an epithelial tumor composed of clear cell cytoplasm with low grade nuclear features, surrounded by an abundant smooth muscle stroma composed of fascicles of spindle cells. Immunohistochemistry revealed the positive reaction of tumor cells for CK7, CD10, CAIX, vimentin and desmin; negative for AMACR. Molecular testing via FISH study shows lack of 3p deletion. Final diagnosis of RCCLMS was made. The aim of this case report is to highlight the importance of awareness of this disease as well as to differentiate RCCLMS from other renal cancers with less favorable prognosis and higher degree of malignancy like clear cell renal cell carcinoma. Keywords: renal cell carcinoma; leiomyomatous stroma; kidney.
Giant retroperitoneal liposarcoma: Surgical management of a difficult case with acute abdomen
Authors:   General Surgery, Unit 2, Regional Hospital of Treviso, Italy (DISCOG, University of Padua)., M Scopelliti , P Pelizzo ,   General Surgery, Unit 2, Regional Hospital of Treviso, Italy (DISCOG, University of Padua)., M Romano ,   General Surgery, Unit 2, Regional Hospital of Treviso, Italy (DISCOG, University of Padua)., P Dott Carraro ,   General Surgery, Unit 2, Regional Hospital of Treviso, Italy (DISCOG, University of Padua)., G Zanus ,   General Surgery, Unit 2, Regional Hospital of Treviso, Italy (DISCOG, University of Padua).
Published: March 2022

Retroperitoneal sarcomas are a relatively rare disease that represent a challenge for the surgeon especially when the mass reaches remarkable size and causes anatomical subversion. Liposarcoma is one of the most common histological subtypes. It often grows asymptomatic till considerable dimensions. From literature we know that the only possibility of radical treatment is the complete surgical resection. Although that approach improves the prognosis, local recurrence is the main cause of mortality. Actually, liposarcomas have no support of complementary radio-chemotherapies. This report describes the clinical presentation and surgical management of a patient with a symptomatic huge retroperitoneal sarcoma.
Hematometrocolpos in chronic vulvovaginal GVHD
Authors:   Department of Pediatric Surgery, Super Speciality Pediatric Hospital and Post Graduate Teaching Institute, Noida, Delhi NCR, India., Aggerwal Neel , Maji Manideepa ,   Department of Pediatric Hematology Oncology, Super Speciality Pediatric Hospital and Post Graduate Teaching Institute, Noida, Delhi NCR, India., Radhakrishnan Nita ,   Department of Pediatric Hematology Oncology, Super Speciality Pediatric Hospital and Post Graduate Teaching Institute, Noida, Delhi NCR, India., Shankar Ravi ,   Department of Pediatric Hematology Oncology, Super Speciality Pediatric Hospital and Post Graduate Teaching Institute, Noida, Delhi NCR, India., Gupta Devendra K ,   Department of Pediatric Surgery, Super Speciality Pediatric Hospital and Post Graduate Teaching Institute, Noida, Delhi NCR, India., Tripathy Sangeeta ,   Department of Radiodiagnosis, Super Speciality Pediatric Hospital and Post Graduate Teaching Institute, Noida, Delhi NCR, India.
Published: March 2022

Chronic Graft-Versus-Host Disease (GvHD) is one of the most common cause of poor quality of life after Hematopoietic Stem Cell Transplantation (HSCT). Chronic GVHD can present with vulvovaginal symptoms which is usually under reported. Only small series have been reported so far and its incidence, pathophysiology, clinical manifestations and management are not well understood. So also, there are currently no vvGVHD screening guidelines for children who undergo HSCT. In this report, we describe our experience of managing an adolescent girl who developed hematometrocolpos as a complication of chronic GVHD after bone marrow transplant.
A qualitative study of the psychological impact of COVID-19 pandemic on foundation year doctors
Authors:   Psychiatric Liaison Team, Birmingham and Solihull Mental Health Foundation Trust, United Kingdom., Odejimi Opeyemi , Brickstock Amanda ,   University Hospital Birmingham, United Kingdom, Akter Khodeza ,   Birmingham and Solihull Mental Health Foundation Trust, United Kingdom., Tadros George ,   Aston Medical School, Aston University, United Kingdom.
Published: March 2022

Globally, COVID-19 pandemic has immensely affected medical education including postgraduate medical education. This study used a qualitative approach to explore the psychological impact of the COVID-19 pandemic on Foundation Year Doctors (FYD). Ten semistructured interviews were conducted. FYDs highlighted the changes in their academic training and working life that occurred during the COVID-19 pandemic and the psychological impact of these changes. This study may be helpful for key stakeholders of foundation training in developing evidence based policies and strategies that improve the wellbeing during and after the COVID-19 pandemic. Keywords: foundation year doctors; COVID-19 pandemic; psychological impact; qualitative study.
Retrocaval ureter coexisting with renal cell carcinoma: A case report and review of literature
Authors:   Department of Surgery, Alex Ekwueme Federal University Teaching Hospital Abakaliki, PMB 102, Abakaliki Ebonyi State, Nigeria., Obasi Ulebe Augustine , Okwudili Obi Anselm ,   Department of Surgery, Alex Ekwueme Federal University Teaching Hospital Abakaliki, PMB 102, Abakaliki Ebonyi State, Nigeria., Ugonna Ogbobe Uchechukwu ,   Department of Surgery, Alex Ekwueme Federal University Teaching Hospital Abakaliki, PMB 102, Abakaliki Ebonyi State, Nigeria., Odo Chinonso ,   Department of Surgery, Alex Ekwueme Federal University Teaching Hospital Abakaliki, PMB 102, Abakaliki Ebonyi State, Nigeria.
Published: March 2022

Background: Retrocaval Ureter (RCU) is a rare congenital anomaly that often presents with obstructive changes in the upper urinary tract which may or may not symptomatic. It arises as a result of an aberration in embryologic development of Inferior Vena Cava (IVC). Commonly occurs in isolation but can occur in association with other anomalies. Few studies have reported RCU co-existing with upper tract Transitional Cell Carcinoma (TCC) but there is no literature report so far of its co-existence with Renal Cell Carcinoma (RCC). Case summary: Hence, we report a case of a 65 year old man with right sided RCC coexisting with RCU. The anomaly was discovered intra-operatively and the patient was offered open right radical nephrectomy with a good post-operative recovery and uneventful follow-up. Conclusion: Retrocaval ureter is a rare congenital anomaly that may occur in isolation or with other associated conditions. To the best of our knowledge, we report the first case of RCU coexisting with renal cell carcinoma. Proper pre-operative evaluation will help to identify these associated anomalies so as to adopt a holistic approach to patient care in order to ensure good treatment outcome. Keywords: radical nephrectomy; renal cell carcinoma; retrocaval ureter; nephroureterectomy.
Granulocytic sarcoma with unusual localizations (breast and stomach) without bone marrow involvement after the allogeneic transplantation
Authors:   Associate Professor, Department of Hematology, Katip Celebi University, Izmir, Turkey., Solmaz Serife , Gul Gulen ,   Assistan Professor, Department of Pathology, Dokuz Eylul University, Izmir, Turkey., Alacacıoglu Inci ,   Professor, Department of Hematology, Dokuz Eylul University Faculty of Medicine Hematology, Izmir, Turkey, Demirkan Fatih ,   Professor, Department of Hematology, Dokuz Eylul University Faculty of Medicine Hematology, Izmir, Turkey, Hayri Ozsan Guner ,   Professor, Department of Hematology, Dokuz Eylul University Faculty of Medicine Hematology, Izmir, Turkey, Balci Pinar ,   Professor, Department of Radiology, Dokuz Eylul University Faculty of Radiology, Izmir, Turkey., Ozkal Sermin ,   Professor, Department of Pathology, Dokuz Eylul University, Izmir, Turkey, Ali Ozcan Mehmet ,   Professor, Department of Hematology, Dokuz Eylul University Faculty of Medicine Hematology, Izmir, Turkey
Published: March 2022

Granulocytic sarcoma (GS) is a rare extramedullary solid tumor composed of immature myeloid cell that is associated with acute myeloid leukemia or myelodysplastic syndrome. Especially, the involvement of the breast as a pattern of relapse after allogeneic bone marrow transplantation (allo SCT) is extremely rare. We report the case of a 57-year-old woman who palpated a painless lump in the superior quadrant of her right breast. Her past medical history was a myelodysplastic syndrome (MDS) treated with bone marrow transplantation. Imaging work-up by mammogram and ultrasonography (US) showed solitary mass suspect of malignancy in breast. Trucut biopsy was performed from the suspect palpable mass of the right breast. Histologic findings were compatible with a granulocytic sarcoma in breast. While she was also evaluated for mass in the breast, also investigated by endoscopy for the symptoms of gastrointestinal system. The endoscopic biopsy showed diffuse neoplastic infiltration similar the pathology of the breast. GS of the breast is a rare extramedullary involvement of hematologic diseases. There are no the specific radyologic features in the presentation with GS of the breast. Our case also showed that careful histopathological review along with all panel of immunohistochemistry is extremely important for diagnose. Keywords: myelodysplastic syndrome; granulocytic sarcoma; allogeneic bone marrow transplantation.
Mobbing: Elements-Causes-Effects
Authors: Vaxevani Valentina , Ioannis Tagarakis A. , Fani Tsolaki , Marios Daskalopoulos , Theodora Papamitsou , Georgios Tagarakis I.
Published: March 2022

Aim: Τo investigate the Mobbing phenomenon as well it’s causes and effects, Material and Methods: We investigated the Mobbing by reviewing previous international research over mobbing. The research material was accumulated after thoroughly examining former studies and reviewing the existing literature, as it was found in the bibliography, data bases, academic libraries, academic journals and the internet. Results: Through the research we tried to define this phenomenon and at the same time to study the constituent elements as well as it’s causes and effects. Finally, we conducted a literature review from previous research in order to investigate this phenomenon and its factors. Conclusions: The current study has concluded that mobbing sadly negatively affects the recipient by creating both direct and indirect effects on various aspects of his daily life, one of which is the workplace.
الاعتراضات الواردة على قراءة البصريين والردّ عليها {الزهراوين نموذجا} .
Authors: محمد محمد توم بابكر
Published: March 2022

يتناول هذا البحث نماذج من اعتراضات المفسرين واللغويين على قراءة البصرييين في الزهراوين ،والرد عليها وإزالة ما أشكل في الظاهر وبيان أن هذا الاعتراض ليس في محله المناسب.

كما توضح الدراسة أيضا أن القراءات المتواترة ليست محلا للرد أو التضعيف ، لورودها وثبوتها عن النبي صل الله ،وأن المقاييس اللغوية ونحوها لا تكون ميزانا لقبول ورد القراءة ، لأن القرآن بقراءاته المتواترة أصل للنحو العربي ، لأنه من عند الله عز وجل ﱩﭐ ﲂ ﲃ ﲄ ﲅ ﲆ ﲇ ﲈ ﲉ  ﲊﲋ ﲌ ﲍ ﲎ ﲏ ﱨ فصلت: ٤٢.

وقداشتمل البحث على مقدمة وتمهيد ومبحثين وخاتمة توصل فيها الباحث إلى أن القراءات التي ثبتت بالتواتر لا ينبغي التفاضل بينها وبين مثيلاتها ، إذ كلٌّ ثابت عن رسول الله صلى الله عليه وسلم بدرجة واحدة ، ومن باب أولى الرد والتضعيف والارتذال ونحوها من عبارات التنقيص .
أثر تبني مفهوم المسؤولية الاجتماعية في جودة الخدمات المصرفية (دراسة ميدانية على بنك فيصل الإسلامي السوداني)
Authors: الزبير محمد احمد زحل
Published: March 2022

هدفت الدراسة إلى قياس أثر تبني مفهوم المسؤولية الاجتماعية في جودة الخدمات المصرفية تمثل المسؤولية الاجتماعية كمتغير مستقل، أما جودة الخدمات المصرفية فتمثل المتغير التابع والذى تم قياسه من خلال عدد من الأبعاد منها ( الملموسية، الاعتمادية، الاستجابة)، وتمثلت مشكلة الدراسة فى ان المسؤولية الاجتماعية ليست مرتبطة بالإنتاجية بل تؤثر سلبا على القيمة الربحية للمساهمين، على الرغم انها تزيد من جودة الخدمات التي يقدمها البنك بشكل عام عبر تعزيز صورتها الذهنية في المجتمع، والتى على ضوءها تم صياغة الفرض الرئيسي توجد علاقة ذات دلالة إحصائية بين تبني مفهوم المسؤولية الاجتماعية وجودة الخدمات المصرفية، وإعتمد الباحث على إستمارة إستبيان للحصول على البيانات تم توزيعها على عينة أختيرت بصورة عشوائية  قصدية من الموظفين فى بنك فيصل الاسلامي السوداني بلغت (60) عميل بصورة عشوائية، وتم تحليلها بإستخدام برنامج (SPSS)، توصلت الدراسة إلى مجموعة من النتائج أهمها وجود علاقة وتأثير مفهوم المسؤولية الاجتماعية في جودة الخدمة المصرفية، وأوصت الدراسة ضرورة الاهتمام بتبني مفهوم المسؤولية الاجتماعية والعمل على المساهمة في الخدمة الاجتماعية لتحسين صورة ودور البنك للاقتصاد والمجتمع.
Faktor-faktor yang mempengaruhi struktur modal pada bank umum syariah
Authors: Rofi’atun Rofi’atun , Nabila Rifda
Published: March 2022

This study aims to analyze the effect of institutional ownership, tangibility, profitability, and liquidity on a capital structure with company size as a moderating variable. The type of this study is descriptive quantitative research using secondary data. The population in this study amounted to 14 sharia commercial banks, 10 sharia commercial banks were used as research samples obtained by using a purposive sampling technique. The results of this study indicate that profitability has a significant effect on capital structure. While the institutional ownership, tangibility, and liquidity has no effect on capital structure. Company size is able to moderate the relationship between institutional ownership and profitability on capital structure.  However, company size is unable to moderate the relationship between tangibility and liquidity on capital structure.
Pengaruh growth opportunity, likuiditas, dan leverage terhadap nilai perusahaan dengan profitabilitas sebagai variabel intervening
Authors: Pratiwi Adillah , Muthohar Ahmad Mifdlol
Published: March 2022

The purpose of this study is to explain the effect of growth opportunity, liquidity, and leverage on firm value with profitability as an intervening variable (study at PT Bank Panin Dubai Syariah for the period 2016-2020). This research uses quantitative research by using path analysis. This study uses secondary data in the form of time series monthly financial data of Bank Panin Dubai Syariah from January 2016 to December 2020. This study indicates that the growth opportunity variable is insignificant to firm value, liquidity harms firm value, leverage harms firm value, and profitability harms firm value. In addition, the growth opportunity is not significant to profitability, liquidity harms profitability, and leverage harms profitability. After path analysis, profitability cannot mediate the effect of growth opportunity on firm value, profitability is not able to mediate the effect of liquidity on firm value, but profitability can mediate the effect of leverage on firm value.
Pengaruh good corporate governance terhadap kinerja keuangan perusahaan perbankan periode 2017-2020
Authors: Maridkha Antin , Himmati Risdiana
Published: March 2022

Good Corporate Governance is the foundation that can make business conditions healthier to grow competence in the business sector and eliminate bribery and corruption cases. The objective-based of this research is to determine the effect of Good Corporate Governance (GCG) on the financial performance of banking companies. The population of this study was 12 companies for four periods, a sample of 44 observational data and data obtained from the IDX official website. The analytical method used is panel data regression. The results of this study indicate that institutional ownership, the board of directors, and the audit board have no significant effect on ROA. Meanwhile, institutional ownership has a significant effect on ROE. The board of directors and the audit committee do not significantly affect ROE. The application of Good Corporate Governance (GCG) in companies to generate profits using ROA and ROE profitability measures does not always affect the company's capacity to generate profits.
Non performing loan: analisis kredit bermasalah di masa pandemi Covid 19
Authors: Musta'da Nisfi , Pramono Nugroho Heri
Published: March 2022

This study aims to determine the effect of LAR, NIM, Inflation, and BI Rate on NPLs during the Covid-19 pandemic. The study population included all conventional commercial banks listed on the Indonesia Stock Exchange in 2020. The sample selection technique used was the purposive sampling method and obtained a sample of 102 observational data. The data used are secondary in the form of financial statements of conventional commercial banks of 2020. The analysis method used is the multiple linear regression method, which is processed using Eviews. The results showed that LAR and NIM had a positive effect on NPLs. In addition, inflation and the BI Rate have no effect on NPLs during the Covid-19 pandemic. Future research can also compare non-performing loans (NPLs) before and after the COVID-19 pandemic.
Effects of Steady State and High-Intensity Exercise on Compensatory Eating Behavior
Authors: Sauers Emily , Klein Jonathan , Witmer Chad , Moir Gavin , Davis Shala
Published: March 2022

Introduction: Studies have shown differences in weight loss between high-intensity interval training (HI) and moderate continuous training (SS) potentially due to compensatory eating behaviors. The aim of this study is to observe the differences in eating behaviors HI and SS exercise.
Methods: Nine lean, college-aged individuals and participated in this study. Subjects completed three trials in a randomized order. During HI, subjects completed 16 intervals alternating between 90% and 50% VO2max (1:1). During SS, subjects ran at 70% VO2max. Subjects sat quietly during the control trial. Food logs were collected 24 hours before and after exercise bouts. Data was analyzed using one-way repeated measures ANOVA. All data are presented as mean ± SE.
Results: Caloric intake was not different between trials (CON: 1558 ± 172 kcal, HI: 1851±150 kcal, SS: 1683±143 kcal, p=0.23). Carbohydrate was not different between trials (CON: 186 ± 25g, HI: 225 ± 24g, SS: 201 ± 23g, p=0.41). Fat was not different between trials (CON: 55 ± 8g, HI: 73 ± 9g, SS: 63 ± 5g, p=0.16). Protein was not different between trials (CON: 78 ± 28g, HI: 69 ± 10g, SS: 70 ± 14g, p=0.64).
Conclusions: Acute HI exercise did not lead to different compensatory eating behaviors compared to SS exercise. Practitioners may feel confident to recommend any exercise model without concern for compensatory overeating.
Pengaruh Gaya Mengajar Komando Terhadap Gerak Dasar Menendang Bola
Authors: Tambing Crystal , Rambitan Mesak A.S.F , Rantung Cindy
Published: March 2022

Dari hasil pengamatan, banyak mahasiswa Pendidikan Jasmani Kesehatan & Rekreasi (PJKR) Fakultas Ilmu Keoalhragaan (FIK) Unima yang belum bisa melakuakn gerak dasar menendang bola dengan baik dan benar. Penelitian ini bertujuan untuk mengetahui seberapa besar pengaruh gaya mengajar komando tehadap gerak dasar menendang bola menggunakan kaki bagian dalam pada pemainan sepak bola. Metode yang digunakan yaitu metode eksperimen. Sampel berasal dari Mahasiswa PJKR FIK Unima yang berjumlah 20 orang yang diambil secara acak (simple random sampling). Instrumen yang digunakan yaitu tes gerka dasar menendang bola menggunakan kaki bagian dalam pada permaianan sepak bola dari awal sampai akhir. Teknik analisa data yang digunakan yaitu teknis analisis statistik Uji-t. Adapun hasil penelitian yaitu thitung = 3,830   ttabel = 2,101. Kesimpulan penelitian ini adalah terdapat pengaruh penerapan gaya mengajar komando terhadap gerak dasar dasar menendang bola menggunakan kaki bagian dalam pada permainan sepak bola Mahasiswa PJKR FIK Unima.
Hubungan Antara Daya Ledak Otot Lengan Dengan Kemampuan Chest Pass Dalam Permainan Bola Basket Pada Siswa SMA N 1 Tondano
Authors: Taaraungan Ospaldo , Malonda Jeane Ros , Sondakh Nofrie
Published: March 2022

Masalah yang ditemukan dalam penelitian ini adalah sebagian besar siswa belum menguasai dengan benar teknik pengaplikasian chest pass dengan efektif dan efesien. Oleh sebab itu peneliti ingin melakukan penelitian dengan tujuan untuk meninjau kembali seberapa besar hubungan antara daya ledak otot lengan dengan kemampuan chest pass dalam permainan bola basket pada siswa SMA Negeri 1 Tondano. Adapun Teknik pengambilan data menggunakan teknik korelasional dengan populasi seluruh Siswa SMA Negeri 1 Tondano sebanyak 18 orang. Adapun berdasarkan dari hasil data yang diolah diperoleh: Hubungan antara daya ledak otot lengan dengan kemampuan chest pass diperoleh koefisien korelasi = 0,82. sedangkan r tabel sebesar 0,734. dengan demikian hubungan antara daya ledak otot lengan dengan kemampuan chest pass terdapat hubungan yang signifikan, dengan besarnya determinasi r2 = 0,6724. Sehingga kesimpulan penelitian ini adalah adanya hubungan antara daya ledak otot lengan dengan kemampuan chest pass dalam permainan bola basket.
Pengaruh Penerapan Gaya Mengajar Komando Terhadap Gerak Dasar Dalam Tolak Peluru Pada Siswa SMP N 1 Sonder
Authors: Rengkendulage Yerison , Podung Beatrix J , Rambitan Mesak
Published: March 2022

Masalah pada penelitian ini yaitu apakah terdapat pengaruh metode mengajar komando terhadap gerak dasar dalam tolak peluru pada siswa SMP N 1 Sonder. Metode yang digunakan dalam penelitian ini adalah metode eksperimen dengan penerapan metode komando. Hasil penelitian menunjukan bahwa rata-rata peningkatan kemampuan gerak dasar dalam Tolak Peluru kelompok eksperimen dengan menggunakan gaya mengajar komando lebih baik dari rata-rata peningkatan kemampuan gerak dasar dalam Tolak Peluru kelompok kontrol yang tidak mendapatkan perlakuan. Hasil pengujian hipotesa penelitian diperoleh thitung senilai 8.60. Berdasarkan tabel distribusi t pada  dengan derajat kebebasan n1 + n2  maka diperoleh ttabel senilai 2.101 jadi thitung lebih besar dari ttabel. Berdasarkan kriteria pengujian jika thitung lebih besar dari ttabel maka HO ditolak yang berarti HA diterima. Melihat uraian data di atas maka dapat disimpulkan menerapkan metode komando dapat memberikan pengaruh terhadap peningkatan gerak dasar tolak peluru pada siswa SMP N 1 Sonder.
Pengaruh Penerapan Gaya Mengajar Latihan Pada Peningkatan Gerak Dasar Passing Bawah Dalam Permainan Bola Voli
Authors: Muhammad Azhar , Mandagi Hendrik S , Legi Berty
Published: March 2022

Permasalahan yang ditemukan adalah belum diketahui gaya mengajar yang efektif untuk diterapkan penguasaan gerak dasar passing bawah pada permainan bola voli dan mengkaji hasil-hasil penelitian yang sudah pernah diteliti oleh peneliti-peneliti terdahulu. Tujuan adalah untuk mengetahui pengaruh penerapan gaya mengajar latihan terhadap peningkatan gerak dasar passing bawah. Metode penelitian yang digunakan adalah metode penelitian deskriptif kualitatif. Rancangan penelitian yang digunakan adalah melalui kajian dan analisis dengan mengumpulkan bukti-bukti luar yang sudah pernah diteliti oleh peneliti sebelumnya. Teknik analisis data yang digunakan adalah dengan menggunakan analisis data deskriptif kualitatif yang bertujuan untuk membuktikan dan menguji hipotesis penelitian. Berdasarkan kajian dan analisis dari beberapa hasil penelitian terdahulu yang relevan, secara deskriptif menunjukkan bahwa keseluruhan yakni 10 hasil penelitian dengan persentase 99,99% mengatakan bahwa gaya mengajar latihan memberikan pengaruh yang signifikan terhadap variabel terikat. Kesimpulan penelitian adalah gaya mengajar latihan memberikan pengaruh signifikan terhadap peningkatan gerak dasar passing bawah dalam permainan bola voli.
Social and legal nuances in improvement of online health education: based on post COVID-19 experience
Authors: Thommandru Abhishek , Chakka Benarji
Published: March 2022

The Coronavirus Disease 2019 (COVID-19) epidemic has inflicted ruination on medical education and healthcare institutions all across the world. The illness has the potential to produce life- hanging circumstances, and ergo poses issues for medical education, as educationists must give lectures safely while maintaining the integrity and abidance of the medical education process. As a result, determining the usability of online learning techniques, as well as their viability and suitability for medical scholars, is critical. The intent of this study was to present an overview of the scenario faced by medical scholars during the COVID-19 epidemic, as well as to identify medical scholars' knowledge, attitudes, and habits environing electronic medical education. To reduce the impact of the COVID-19 epidemic on medical education and progression, specific preventives and reforms must be enforced. The moment for change has here, and there should be wide support and excitement for effective druthers, like as online training and virtual clinical practise, to minimise the disturbance. Following these preventives, hands-on experience in a safe environment might be offered. Given the fact that covid-19 has led to economic challenges, there is a need to ensure that there is enough funding towards improving health professionals’ education.
Soft b derived set in soft tritopological spaces
Authors: Bharathi S. , Devi T.
Published: March 2022

This paper deals with the concept and properties of trio soft limit point, trio soft b limit point and trio soft b derived set in soft tritopological spaces.
Hematological and biochemical parameters among obese students at the PSAU, Alkharj, KSA
Authors: Alshaya Dalal. S. , Alafari Hayat , Alnaam Yaser , Alsiary Rawiah , Alsofyani Abeer , Altoub Mashael , Bukhari Talat , Alanazi Aisha , Alonazi Noufa , Alanazi Maha , Alsaihati Hajir , Zaki Awal , Shaya Abdulkarim S. Bin , Aldheyan Noura , Alharthi Nahed , Alanazi Zyad , Alqahtani Abdulrahman , Alzehairi Salman , Alenezi Nadiyah , Alanazi Rakan , Alruwaili Naif , AlAmodi Hiba S , Alanazi Essa E. , Alhababi Fadel H. , Aldeailej Ibrahim M. , Aalenezy Awwad K. , Zekri Abulrahman , Alenzi Faris Q. B.
Published: March 2022

Management of obesity represents a global problem that challenges the provision of healthcare services in most countries. Saudi Arabia ranked number 29 on a 2007 list of countries with 6% of its population being overweight (BMI > 25).In a university setting, we studied hematological parameters (including whole blood counts, haemoglobin and platelets), the presence of basophilia, iron levels and lipid profiles in obese students, and also in non-obese student controls. We found a significant increase in whole blood count in obese compared to healthy individuals, and also found a high level of basophilia compared to healthy controls.  We also report that the obese student group suffered from low iron levels, and also a reduced total iron binding capacity, as compared to healthy controls. Levels of cholesterol and triglycerides was significantly higher in obese students compared to healthy controls. This study can be interpreted that universities across the Kingdom, and beyond, should consider targeting obesity management in their students to try to reduce the prevalence of obesity and associated disorders, and to support such healthcare programs by offering a variety of environmental, physical exercise and nutritional interventions.
An investigation of different DDOS attack detection methods in software-defined networks
Authors: Kaur Gaganjot , Gupta Prinima
Published: March 2022

Software-Defined Network is more vulnerable to more frequent and severe security attacks. Distributed Denial of service (DDoS) spasms corrupt network along with hinder efficiency and performance significantly. DDoS spasms lead to exhaustion of network means, thereby stopping the controller and impeding normal activities. Detection of DDoS attacks requires different classification techniques that provide accurate and efficient decision-making. Various techniques to detect the attacks are proposed in the existing literature. However, analysis of various works reveals various shortcomings of different techniques. In this paper, the existing techniques are analyzed in terms of their accuracy and MSE, and seven methods are compared with regards to suitability to counter DDoS attacks efficiently. Analysis of the results shows limitations and sets the tone for future studies on the topic. Overall, it is suggested to continue looking for better techniques to improve upon the existing learning and experiences gained and provide more accurate results.
Educating rural girls in their life skills through painting
Authors: Jayasree A. , Murugeswari N.
Published: March 2022

Education is the foundation stone and girls are the pillars for the sustainable development of a nation. National Education Policy 2020 of India has touched life skill to bring forth some modifications in curriculum for mental well-being of adolescents, but an exclusive picture mode is missing in all life skill fields of studies. Focusing on the literacy on selected life skills through a contemporary creative medium, this article presents a new methodological approach in life skill training. Pictures generally attract children.A module with digital paintings on  life skill quotes was prepared by the researcher and after training of rural girl participants, significant difference in the calculated T-test value from the table value was observed in analysis. Thus result gave initial evidence within the context by the participants on the effectiveness of the use of digital painting in the module in training life skills selected for the study, which has great educational significance in mental health area.
Research on the Impact of OFDI on China's Industrial Structure Upgrading
Authors: Wu Jiahao , Wang Zongming
Published: March 2022

China's economy is currently in a critical "transition period", the conversion of the source of economic growth, economic restructuring is the key to ensure that China's economy continues to develop well and steadily. Among them, the transformation and upgrading of industrial structure will be the top priority of future economic development. This project is carried out in the context of China's active promotion of the "Belt and Road" construction and deepening supply-side reform, and it is important to explore the impact of OFDI on domestic industrial structure, which is important for China to resolve excess production capacity, accelerate technology accumulation and finally realize the optimization and upgrading of industrial structure. In this paper, the specific impact of OFDI on China's domestic industrial structure upgrading and the magnitude of the effect of OFDI to countries along the "Belt and Road" is the main line of research, and the path and mechanism of OFDI to countries along the "Belt and Road" are discussed. The main line of research is to explore the path and mechanism of OFDI's influence on China's domestic industrial structure upgrading in countries along the "Belt and Road".