bluuebunny/crossref_metadata_2025 huggingface dataset:
Pulmonary Delivery of Docetaxel and Celecoxib by PLGA Porous Microparticles for
Their Synergistic Effects Against Lung Cancer
Authors: Emami Jaber , Ziaei Elham , Rezazadeh Mahboubeh , Kazemi Moloud
Published: August 2021

Background:

using a combination of chemotherapeutic agents with novel drug delivery platforms to enhance
the anticancer efficacy of the drug and minimizing the side effects, is imperative to lung cancer treatments.

Objective:

The aim of the present study was to develop, characterize, and optimize porous poly (D, L-lactic-co-glycolic
acid) (PLGA) microparticles for simultaneous delivery of docetaxel (DTX) and celecoxib (CXB) through the pulmonary
route for lung cancer.

Methods:

Drug-loaded porous microparticles were prepared by an emulsion solvent evaporation method. The impact
of various processing and formulation variables including PLGA amount, dichloromethane volume, homogenization
speed, polyvinyl alcohol volume, and concentration, was assessed based on entrapment efficiency, mean release time,
particle size, mass median aerodynamic diameter, fine particle fraction, and geometric standard deviation using a twolevel
factorial design. An optimized formulation was prepared and evaluated in terms of size and morphology using a
scanning electron microscope.

Results:

FTIR, DSC, and XRD analyses confirmed drug entrapment and revealed no drug-polymer chemical interaction.
Cytotoxicity of DTX along with CXB against A549 cells was significantly enhanced compared to DTX and CXB
alone and the combination of DTX and CXB showed the greatest synergistic effect at a 1/500 ratio.

Conclusion:

In conclusion, the results of the present study suggest that encapsulation of DTX and CXB in porous
PLGA microspheres with desirable features is feasible and their pulmonary co-administration would be a promising
strategy for the effective and less toxic treatment of various lung cancers.
Strategic Approaches to Target the Enzymes using Natural Compounds
for the Management of Alzheimer’s Disease: A Review
Authors: Ahmad Syed Sayeed , Younis Kaiser , Philippe Jeandet , Aschner Michael , Khan Haroon
Published: August 2021

:

Alzheimer's Disease (AD) is a chronic neurodegenerative disease. It is clinically characterized
by memory loss and intellectual decrease, among other neurological deficits. The etiology
of AD is not completely understood but includes amyloid plaques and intracellular helical filaments
as well as neurofibrillary tangles with hyperphosphorylated tau protein. AD is also associated
with alterations in amyloid processing genes, such as PSEN1 or PSEN2 and APP. The modulation
of the immune system, cholesterol metabolism, and synaptic vesicle endocytosis have all been
shown to remediate AD. In this review, enzymes such as AChE, BuChE, β-secretase, γ-secretase,
MAO, and RAGE are discussed as potential targets for AD treatment. The aim of this review was
to address the molecular mechanisms as well as various genetic factors in AD etiology. The use of
natural compounds against these targets might be beneficial for the management of AD.
Efficacy and Outcomes of a Novel Telephone-based Gout Disease Management Program
Authors: Al Harash Abdalhamid , Laginya Gina , Ayoub William T.
Published: August 2021

Objective:

Gout is the most common inflammatory arthritis in the United States. Despite published guidelines, management remains suboptimal, leading to unnecessary morbidity and increased cost of care. We have designed the gout disease management program (GDMP) to improve outcomes, increase patient satisfaction, and decrease healthcare utilization.

Methods:

Gout patients were seen at their usual rheumatology clinical visit and offered participation in the GDMP. Data were collected between April 2017 and November 2019. Serum uric acid (SUA) levels were measured at the initial outpatient encounter, at the entrance to GDMP, and every 4 weeks until SUA was at the goal of ≤6 mg/dl. Through telephonic encounters, gout-related recent hospitalizations, and ER or urgent care visits since the last encounter were ascertained. Self-reported gout medication usage and adherence were also determined. Patient satisfaction with GDMP was surveyed using a 5-point Likert scale.

Results:

A total of 158 patients were enrolled, of which 112 had ≥ 1 telephone encounter and were included in our analyses. During the telephone phase, 79 patients (70%) achieved the SUA goal of ≤6.0 mg/dl. Only 3 patients (2.6%) required hospitalization or visits to an ER or urgent care center due to gout flare, and 98% rated their encounter as a 5 on the 5-point Likert scale.

Conclusion:

Our telephone-based management program for gout led to improved clinical outcomes as defined by the ACR guidelines, decreased healthcare visits, and had high patient satisfaction.

Significance and Innovations:

• First telephone-based, rheumatology providers-led study to manage gout

• Additional evidence to confirm the feasibility and benefit of telemedicine in common diseases

• First study to show excellent patient satisfaction
The Role of Attitude, Behavior, and Road Conditions in Traffic Violation among Workers and Students in Bandung City, Indonesia
Authors: Prasetyanto Dwi , Rizki Muhamad , Maulana Andrean
Published: August 2021

Introduction:

This study aims to explore the attitudes towards riding safety, behavior regarding safety gear, documents, and vehicle and riding preparedness, and perceived road conditions among worker and student motorcyclists, and the influence of these on their violation behavior.

Methods:

To further explore the violation behavior, the effects of the infrastructure quality, personal and travel characteristics, and the experience of accidents were also included in the variables. This study collected data on motorcycle users’ behavior in Bandung City and used Structural Equation Modeling (SEM).

Results and Discussion:

This research underlines that behavior regarding safety gear, documents, and vehicle and riding preparedness is an important factor that decreases the violation behavior. Interestingly, a positive attitude towards safe riding does not straightforwardly lead to better behavior in preparing the vehicle, safety gear, and documents.

Conclusion:

Good quality infrastructure also promotes a reduction of traffic violations. Improving road infrastructure safety and both promoting and monitoring users’ safe riding behavior are suggested to lower the number of traffic violations.
Chimeric Antigen Receptor T-cells (CARs) in Cancer Treatment
Authors: Zam Wissam , Assaad Amany
Published: August 2021

Background:

Cancer is one of the leading causes of death worldwide. Chemotherapy, radiation
therapy, and stem cell transplantation were the main cancer treatment approaches for several
years but due to their limited effectiveness, there was a constant search for new therapeutic approaches.
Cancer immunotherapy that utilizes and enhances the normal capacity of the patient's immune
system was used to fight against cancer. Genetically engineered T-cells that express Chimeric
Antigen Receptors (CARs) showed remarkable anti-tumor activity against hematologic malignancies
and are now being investigated in a variety of solid tumors. The use of this therapy in the last
few years has been successful, achieving great success in improving the quality of life and prolonging
the survival time of patients with a reduction in remission rates. However, many challenges
still need to be resolved in order for this technology to gain widespread adoption.

Objective:

This review summarizes various experimental approaches towards the use of CAR T--
cells in hematologic malignancies and solid tumors.

Conclusion:

Finally, we address the challenges posed by CAR T-cells and discuss strategies for improving
the performance of these T-cells in fighting cancers.
Development and Validation of a Simple Micromethod for the Determination of Metformin in Plasma by HPLC-UV for Application in Pharmacokinetic Studies
Authors: Morales-Barragán Miriam N. , del Carmen Romero-Méndez María , del Carmen Milán-Segovia Rosa , Rodríguez-Rivera Jaime G. , Aguilar-Torres María A. , Romano-Moreno Silvia
Published: August 2021

Background:

Metformin is the first-line drug to enhance glycemic control of type 2 DIABETES
Mellitus (DM2) patients. Some reported methods to determine plasma metformin by
HPLC-UV are not sensitive enough. Other methods require long extraction processes.

Objective:

The objective of this study was to develop and validate a simple and rapid analytical
method to determine plasma metformin by HPLC-UV for application in a population pharmacokinetic
study.

Methods:

Analyte was extracted from plasma by a simple protein precipitation technique using
trichloroacetic acid (15%, w/v) as the precipitating agent. Plasma samples were analyzed using a
C18 column (3.0 x 150 mm, 3.5 μm) under isocratic elution with 30 mM sodium hexansulfonate
(pH 5) and acetonitrile (95: 5, v,v).

Results:

The limit of quantification (LOQ) was 0.1 μg mL-1 and the calibration curve was linear up
to 4 μg mL-1 with a correlation coefficient >0.99. The mean recovery for metformin using this extraction
procedure was 84.4 - 86.6%. The intra- and inter-day coefficients of variation and percent
error values of the assayed method were <20% and <15% for LOQ and QCs, respectively. Metformin
was stable in plasma samples by subjecting it to three freeze-thaw cycles and storing it up to
60 days at -80°C. This method was applied to determine plasma metformin concentrations in patients
with type 2 diabetes mellitus treated with this drug.

Conclusion:

The HPLC-UV method developed is selective, accurate and precise for the quantification
of metformin in plasma samples, since sample processing is fast and simple, in addition to being
applicable in pharmacokinetic studies.
Modelos híbridos de indexação social: análise do repositório de fanfictions Archive of Our Own (AO3)
Authors: Silva Bruna Daniele de Oliveira , Sabbag Deise Maria Antonio
Published: August 2021

The digital environment has enabled new forms of production, consumption and organization of digital content, such as social indexing. This indexing consists onthe attribution of free tags by users or communities. Fanfictions are fictional stories created by fans, they are deposited in repositories and their indexing is performed by the authors themselves, using a hybrid system of controlled and natural languages. The research aimed to describe qualitatively the social indexing implemented in the fanfictions repositor,Archive of Our Own, in order to make some reflections about the new modes of production and user participation in the representation of content onthe social web. It is concluded that the indexing performed in the analyzed repository adds a curated folkonomy through a team of volunteers trained to follow specific norms. The repository establishes a hybrid and participatory model for indexing itscontent, adding a semantic dimension while ensuring the recovery.
Convite à emancipação à luz da mediação da informação makerspace e inovações no contexto da biblioteca pública
Authors: Mello Mariana Rodrigues Gomes de , Camillo Everton da Silva , Araújo Leda Maria , Sala Fabiana , Alves Rosemari Pereira dos Santos
Published: August 2021

The public library brings with itself the social dimension, which creates a space for training and social change. However, society requires innovations and libraries are part of this context. Thus, this work is justified by understanding the role that public libraries have for society. It lacks spaces for access to innovative technologies and information mediation actions. To make the research feasible, the research problem consists on the following question: to what extent do the investigations on public libraries aim at increasing innovation and makerspaces to reinforce their social function? Then, the aim of this study is to ascertain the number of publications in scientific journals that relate innovation and the makerspace in the emancipatory context of public libraries. Methodologically, it was drawn a qualitative and quantitative exploratory research. An exploratory search was carried out in databases considering papers pusblished by authors dealing with the themes, as well as in the abstracts of papers in journals and proceedings in the databases Library and Information Science Abstracts (LISA) and the Base de Dados Referenciais de Artigos de Periódicos em Ciência da Informação (BRAPCI). Findings reveal that it lacks the relationship between public libraries, makerspace and information mediation, concomitantly, in investigations in the area of Information Science between the years 2009 and 2019.
KAJIAN PENAMBAHAN PATI KENTANG (Solanum tuberosum L.) TERHADAP KARAKTERISTIK SOSIS DAGING SAPI
Authors:   Universitas Pendidikan Indonesia, Yuniar Macicha Elvira , Azizah Dewi Nur ,   Universitas Pendidikan Indonesia
Published: August 2021

Sosis merupakan produk olahan daging yang memiliki nilai gizi tinggi. Pada pembuatan sosis diperlukan bahan tambahan lain sebagai pengisinya. Pati kentang memiliki kadar amilopektin sebesar 78.96% yang baik dalam pembentukan tekstur apabila digunakan sebagai bahan pengisi. Tujuan dari penelitian ini adalah untuk mengetahui karakteristik sosis daging sapi dengan penambahan pati kentang dan mengetahui konsentrasi pati kentang yang tepat untuk menghasilkan produk dengan karakteristik yang baik dan disukai panelis. Desain penelitian yang digunakan terdiri dari satu faktor yaitu perbedaan konsentrasi pati kentang dengan 4 perlakuan (10%; 20%; 30%; 40%) dan 1 ulangan. Secara keseluruhan, karakteristik sosis daging sapi dengan penambahan pati kentang memiliki warna merah dan berbintik, aroma daging dan rempah, tekstur kenyal, dan rasa gurih. Sosis daging sapi dengan konsentrasi pati kentang 30% memperoleh nilai rata-rata tertinggi terhadap kesukaan panelis pada seluruh atribut yang meliputi warna, aroma, tekstur, dan rasa.
CHEMICAL AND ORGANOLEPTIC PROPERTIES OF COOKIES FROM CORN FLOUR AND MUNG BEAN AS A GLUTEN-FREE SNACKS
Authors:   Politeknik Negeri Jember, Rosiana Nita Maria , Susianti Kurnia Cahya ,   Politeknik Negeri Jember, Suryana Arinda Lironika ,   Politeknik Negeri Jember
Published: August 2021

Autism disorders can reduce the ability to communicate, socialize, and respond to the environment. Some children with autism disorders are allergic to gluten. This study aims to analyze the characteristics of gluten-free cookies from corn flour and mung bean flour. The experimental design used was a Randomized Block Design. The formulation of corn flour : mung bean flour were 60%: 40%, 55%: 45%, 50%: 50%, 45%: 55%, 40%: 60%, each treatment was repeated 5 times. The best treatment is the formulation of 50% corn flour + 50% mung bean flour. The nutrient content of cookies (per 100g) are 18.47 kcal energy, 4.94 grams of protein, 6.93 grams of fat, 25.33 grams of carbohydrates. The serving size for autism children aged 4-6 years is 8 pieces (± 80 grams) per day with 2 feeds.
THE EFFECT OF ALOE VERA GEL EDIBLE COATING AND GLYCEROL ON THE PHYSICOCHEMICAL CHARACTERISTICS OF RED GRAPES (Vitis vinifera L.)
Authors:   Politeknik Negeri Subang, Destiana Irna Dwi , Anisa Zulfa Nur ,   Politeknik Negeri Subang, Mukminah Nurul ,   Politeknik Negeri Subang
Published: August 2021

Red grape (Vitis vinifera L.) is easy to get perishable and wrinkles/wilt, brown in color, and soft fruit flesh. one of the benefits of edible coating is that it can protect products from microbiological damage. The ability of aloe vera as an antimicrobial can be a potential ingredient for making edible coatings,. Besides, the use of aloe vera as an edible coating is also very easy and affordable (cheap). The purposes of this study are to determine the effect of glycerol addition and the best treatment of aloe vera edible coating on the quality of the red grape. The experiment used a completely randomized design (CRD) as an experimental design with 4 treatment factors, namely the concentration of glycerol (P1=0%, P2=3%, P3=5%, P4=7%). Each concentration was repeated three times. The parameters observed were physicochemical characteristics (weight reduction, pH, total titrated acid), hedonic quality test (color, aroma, texture). The results showed that the treatment of 3% glycerol was the best treatment since it could maintain the condition of the fruit well during storage, especially weight reduction, aromas, and textures. Parameters that highly affect the quality of red grapes are texture and weight loss.
Analisis Wacana Free West Papua Campaign pada Operasi Militer Indonesia dalam Konflik Nduga: Sebuah Tinjauan Kritis
Authors: Nur Rumila Diana , Effendi Yusli
Published: August 2021

Mainstream narratives on Indonesia's military operation in West Papua describe it to help the conflicting region achieve peace and prosperity. This hegemonic and widely held public opinion is more often used to justify the behavior of the Indonesian Government in West Papua. This research aims to offer an alternative perspective on the matter by looking at the narrative promoted and written by Free West Papua Campaign (FWPC) on their news reports about the Nduga Conflict in 2018-2019 from their website: freewestpapua.org. Norman Fairclough's critical discourse analysis examines the discourse created from the news coverage within the three-dimensional analysis, namely the textual, the discourse practices, and sociocultural dimensions. Results show that FWPC depicts Indonesia's military as exploiters of the indigenous Papuans. At the same time, FWPC also tries to build a sense of belonging to gain support from the international society and online activists.
Revisionisme Sejarah Jepang terhadap Peristiwa Pembantaian Nanjing
Authors: Rianti Sukma Nanda Ni Putu , Purnomo Joko
Published: August 2021

This study examines Japan's historical revisionism related to the Nanjing Massacre during its 1937 invasion in the People's Republic of China. In 2015, UNESCO's response to include the Nanjing Massacre in the "Memory of the World Register" received backlash from Abe's government, resulting in a budget suspension from Japan. Japan wanted to be seen as a good country, leaving behind its past image as a war aggressor through historical revisionism. Using the concept of Shared Beliefs and Therapeutic Value, this article analyses homogeneous Japanese society that regards the Nanjing Massacre as something the Japanese government should not be apologetic about and the heterogeneous historical facts of the massacre itself. Finding suggests that Therapeutic Value from the denial comes from the failure of the U.S. and its allies to provide a deterrent effect post-WWII that resulted in victimization and melodrama promoted by the Japanese government. The government also uses narratives such as Toa Renmei Ron and Kami no Kuni as the main argument to boost Japanese superiority as a country. However, such revisionist strategy of the Nanjing Massacre is proven a failure to promote peace among the younger generation.
Menuju Surabaya Green City Melalui Kerjasama Kota Kembar Surabaya-Kitakyushu
Authors: Widiana Fany , Utomo Ario Bimo
Published: August 2021

The sister city collaboration between Surabaya and Kitakyushu is an example of the active cooperation of local governments in Indonesia. Conceptually, this kind of cooperation is also called paradiplomacy or diplomatic activity carried out by local governments with other regions in foreign countries. This article takes a case study of the sister cities of Surabaya and Kitakyushu to then look at the institutionalization aspect as a dimension that can be seen from paradiplomacy. Using the Surabaya point of view, the institutionalization points that the writer will review in this article are (1) the formation of a special ministry or department; (2) establishment of permanent subnational offices; (3) official visits of regional authorities to foreign territories and countries; (4) participation in various international events organized by foreign actors; (5) formation and participation in multilateral global & cross-border regional networks and working groups in specific fields; and (6) regional authorization participation in international events organized by foreign entities in official delegations of the central government.
Zachowania zdrowotne kobiet z nietrzymaniem moczu
Authors:   Centrum Diagnostyczno-Lecznicze Barska we Włocławku, Wojtycka Bożena , Haor Beata ,   Państwowa Uczelnia Zawodowa we Włocławku
Published: August 2021

Introduction. Modifying health behaviors is an important element of the prevention and conservative treatment of urinary incontinence. Aim. The aim of the study is to analyze the health behavior of women with urinary incontinence. Material and methods. The study involved 100 patients with urinary incontinence. The diagnostic survey method and the estimation method, the survey technique, the estimation scale technique and the Inventory of Health Behavior questionnaire were used. Results. Women with urinary incontinence rated their health behaviors the highest in the following categories: preventive behaviors, correct eating habits and a positive mental attitude. The respondents rated their health practices the lowest. Conclusions. The health behavior of women with urinary incontinence is interpreted as average.
Ocena satysfakcji rodziców z leczenia ludzkim rekombinowanym hormonem wzrostu dzieci z somatotropinową niedoczynnością przysadki
Authors:   Państwowa Uczelnia Zawodowa we Włocławku, Grzelak Lech , Wiśniewska Anna ,   Szpital Dziecięcy w Toruniu, Ślusarz Robert ,   Państwowa Uczelnia Zawodowa we Włocławku
Published: August 2021

Introduction. Short stature is a term for a child's height below two standard deviations from the norms adopted for sex and age. In Poland, treatment with recombinant growth hormone of somatotropin hypopituitarism is reimbursed under the National Health Fund drug programs. Administration of growth hormone in the form of daily injections is cumbersome and requires the in-volvement of the whole family in the treatment process. The multidirectional action of GH improves the quality of life of small patients. Aim. The aim of the study is to analyze parents' satisfaction with growth hor-mone treatment in children with somatotropin hypopituitarism. Materiał and methods. The study involved 69 parents of children with so-matotropin hypopituitarism treated with growth hormone at the Department of Pediatrics, Endocrinology, Diabetology and Pediatric Neurology at the Chil-dren"s Hospital in Torun. The research used the own questionnaire and KID-SCREEN questionnaire for parents. Results. Parents of children with somatotropin hypopituitarism are satisfied with the treatment with recombinant growth hormone and evaluate the treat-ment positively. During growth hormone therapy, they highly estimate the quality of their children’s lives. There is a correlation between parents' as-sessment of growth hormone therapy and the change in their children's quality of life. Conclusions. Satisfaction with treatment recombinant growth hormone de-pends on the duration of treatment, achieved growth results and the child's age.
Świadomość pacjentów na temat późnych powikłań cukrzycy typu 2
Authors:   Państwowa Uczelnia Zawodowa we Włocławku, Antczak-Komoterska Anna , Boruczkowska Beata ,   Centrum Diagnostyczno-Lecznicze Barska we Włocławku
Published: August 2021

Admission. Diabetes mellitus is a group of metabolic diseases characterized by hyperglycaemia resulting from a defect in the production or function of insulin secreted by the beta cells of the pancreas. The most common form of diabetes is type 2 diabetes, in which there is primarily a decreased sensitivity of tissues to insulin (insulin resistance). Long-term diabetes leads to many serious complications that affect many organs, such as the eyes, kidneys and nerve fibers. Aim. The aim of the study was to assess the patients' awareness of late compli-cation of type 2 diabetes. Material and methods. The study involved 100 female and male patients treated at the CDL Barska Diabetes Clinic. The diagnostic survey method was selected, the survey technique and the analysis of medical records were used. The research tool used in the work was the original questionnaire and medical documentation. Results. The conducted research shows that the vast majority of patients are women (63%), over 60 (40%), living in the city (62%), professionally active (44%), who were ill for less than 5 years (45%) . Most respondents indicated participation in ophthalmological consultations (65%). The largest group of respondents indicated a complication in the form of hypertension (37.4%), visual impairment (23.7%), and the least indicated a diabetic foot (0.7%).
Pendidikan Agama Islam Non Formal dalam Setting Inklusif bagi Anak dengan Hambatan Pendengaran
Authors: Pamungkas Bayu , Alimin Zaenal
Published: August 2021

Penelitian ini bertujuan untuk menggambarkan pelaksanaan pendidikan agama Islam bagi anak dengan hambatan pendengaran di Masjid Khoiru Ummah Semarang. Jenis penelitian ini adalah penelitian kualitatif deskriptif menggunakan desain studi kasus. Teknik observasi partisipatif dan wawancara semi terstruktur terhadap subjek penelitian yakni tiga pembimbing anak dengan hambatan pendengaran dan tiga anak dengan hambatan pendengaran digunakan untuk pengumpulan data. Dari penelitian ini diperoleh data hasil penelitian sebagai berikut: (1) dalam proses pendidikan  terdapat lima kegiatan pendidikan agama. Seluruh pelaksanaan kegiatan melibatkan masyarakat umum, BISINDO digunakan sebagai sistem komunikasi utamanya selain penggunaan Komunikasi total, Contextual Teaching and Learning diterapkan sebagai metode pembelajaran, serta materi pendidikan agama yang diajarkan disesuaikam; (2) dalam setting kegiatan terdapat tiga setting yang disesuaikan dengan kompleksitas materi yang diajarkan; (3) profil anak dengan hambatan pendengaran yang mengikuti pendidikan agama adalah anak dengan hambatan pendengaran usia remaja. Mereka juga mengajak anak dengan hambatan pendengaran lain untuk ikut bergabung; (4) terkait profil pembimbing anak dengan hambatan pendengaran, mereka adalah masyarakat yang sukarela membimbing anak dengan hambatan pendengaran yang kemudian mengikuti pelatihan intensif; (5) hasil pendidikan agama menunjukkan bahwa anak dengan hambatan pendengaran memiliki kefahaman beragama, ketaatan dalam beribadah dan hubungan bermasyarakat yang baik.
Magical Science Sebagai Media Pembelajaran IPA Berbasis Website Untuk Siswa Tunarungu
Authors: Tarjiah Indina , Kurniawan Erfan , Bagaskorowati Riana
Published: August 2021

Penelitian ini bertujuan untuk menghasilkan produk berupa media Magical Science untuk memvisualisasikan daur hidup hewan Kupu-Kupu dalam bentuk 3D bagi siswa tunarungu. Media ini menggunakan metode Research and Development (RnD) dengan model pengembangan Sugiyono yang meliputi tahap potensi dan masalah, pengumpulan data, desain produk, validasi desain, revisi desain, uji coba produk, dan revisi produk. Validasi dilakukan oleh tiga ahli yaitu ahli media, ahli tunarungu, dan ahli materi dengan hasil rata-rata keseluruhan yang telah dicapai adalah baik, yaitu dengan nilai 3,36 dari nilai maksimal 4. Media Magical Science diujicobakan kepada enam siswa kelas V di SLB Negeri 4 Jakarta. Hasil penelitian ini menunjukkan bahwa media Magical Science ini dapat digunakan untuk memvisualisasikan daur hidup hewan Kupu-Kupu dalam bentuk 3D. Diharapkan guru dapat menggunakan media Magical Science pada pembelajaran Ilmu Pengetahuan Alam.
Pelaksanaan Pembelajaran Jarak Jauh Bagi Anak Berkebutuhan Khusus (Survei terhadap Orangtua dan Guru di Lampung)
Authors: Wardany Ossy Firstanti , Sani Yulvia
Published: August 2021

Pembelajaran Jarak Jauh (PJJ) menjadi solusi menjembatani keharusan untuk berada di rumah untukmenghindari penularan Covid-19 dan  tepat memberikan pelayanan pembelajaran bagi anak berkebutuhan khusus (ABK). Penelitian merupakan penelitian survei yang dilakukan terhadap 58 guru dan 36 orangtua ABK di Provinsi Lampung. Tujuan penelitian adalah menggali bagaimana persepsi maupun pengalaman dan permasalahan terkait pembelajaran jarak jauh melalui sudut pandang orangtua dan guru anak berkebutuhan khusus. Hasil menunjukkan selama pandemi Covid-19,  pembelajaran jarak jauh dilaksanakan dalam bentuk pembelajaran daring. Guru mengungkap bahwa permasalah terkait sinyal internet, kesiapan anak dalam belajar, kondisi dan kemampuan orangtua dalam membimbing anak menjadi penentu keberhasilan PJJ bagi anak berkebutuhan khusus. PJJ memerlukan pendampingan dari orangtua dan pada pelaksanaannya masih ditemukan kendala terkait konektivitas internet, waktu yang dimiliki, keadaan emosi dan kesiapan anak belajar dari rumah, serta kompetensi dan kemampuan orangtua dalam pengasuhan anak dan pembelajaran anak berkebutuhan khusus di rumah. Berbagai pelatihan terkait penggunaan teknologi, pengasuhan anak, dan pelatihan mengajar jarak jauh sangat diperlukan baik bagi guru maupun orangtua.
Peran Bimbingan dan Konseling di Sekolah Inklusif
Authors: Irmayanti Rima , Yuliani Wiwin
Published: August 2021

Abstrak: Tujuan dari penelitian ini yaitu untuk mengetahui peran bimbingan dan konseling dalam penyelenggaraan pendidikan inklusif di sekolah-sekolah formal, utamanya pada jenjang TK, SMP, dan SMA.  metode penelitian yang digunakan yaitu deskriptif kualitatif, dengan subjek penelitian sebanyak tiga orang guru BK, di antaranya yaitu, 1) Sr guru BK dari SMP Negeri 3 Bale endah Kabupaten Bandung, 2) NE pengurus dari Yayasan Arafah Mukapayung Cililin, dan 3) MY guru BK dari SMA Negeri 1 Marga Asih. Hasil penelitian mengungkapkan bahwa peran BK dalam pendidikan inklusif di sekolah yaitu; a) mengidentifikasi siswa berkebutuhan khusus melalui alat tes maupun non tes, b) menyusun program pendidikan khusus/inklusif, c) pelaksanaan layanan BK terhadap siswa berkebutuhan khusus beragam disesuaikan dengan jenisnya, temporer atau permanen.  Kata Kunci: Bimbingan dan Konseling, Pendidikan Inklusif, Sekolah Formal
The role of perceived social support on social skills of student with special needs
Authors: Rahmi Iftita
Published: August 2021

The purpose of this study was to discover the relationship between perceived social support from family and peers on the social skills of students with special needs. This study was conducted with postsecondary education students in a 3-year college (N=42) with various types of disability. This study used a quantitative method with a correlational non-experimental approach. The results of this study indicated that perceived social support from family and friends affect the social skills of students with special needs. The form of the social support associated with the social skills of special needs students is emotional and information support. The implications and possible applications of the relationship between social support and social skills among college students with special needs are discussed.
Analyzing Social Media to Explore the Attitudes and Behaviors Following the Announcement of Successful COVID-19 Vaccine Trials: Infodemiology Study
Authors: Boucher Jean-Christophe , Cornelson Kirsten , Benham Jamie L , Fullerton Madison M , Tang Theresa , Constantinescu Cora , Mourali Mehdi , Oxoby Robert J , Marshall Deborah A , Hemmati Hadi , Badami Abbas , Hu Jia , Lang Raynell
Published: August 2021

Background

The rollout of COVID-19 vaccines has brought vaccine hesitancy to the forefront in managing this pandemic. COVID-19 vaccine hesitancy is fundamentally different from that of other vaccines due to the new technologies being used, rapid development, and widespread global distribution. Attitudes on vaccines are largely driven by online information, particularly information on social media. The first step toward influencing attitudes about immunization is understanding the current patterns of communication that characterize the immunization debate on social media platforms.

Objective

We aimed to evaluate societal attitudes, communication trends, and barriers to COVID-19 vaccine uptake through social media content analysis to inform communication strategies promoting vaccine acceptance.

Methods

Social network analysis (SNA) and unsupervised machine learning were used to characterize COVID-19 vaccine content on Twitter globally. Tweets published in English and French were collected through the Twitter application programming interface between November 19 and 26, 2020, just following the announcement of initial COVID-19 vaccine trials. SNA was used to identify social media clusters expressing mistrustful opinions on COVID-19 vaccination. Based on the SNA results, an unsupervised machine learning approach to natural language processing using a sentence-level algorithm transfer function to detect semantic textual similarity was performed in order to identify the main themes of vaccine hesitancy.

Results

The tweets (n=636,516) identified that the main themes driving the vaccine hesitancy conversation were concerns of safety, efficacy, and freedom, and mistrust in institutions (either the government or multinational corporations). A main theme was the safety and efficacy of mRNA technology and side effects. The conversation around efficacy was that vaccines were unlikely to completely rid the population of COVID-19, polymerase chain reaction testing is flawed, and there is no indication of long-term T-cell immunity for COVID-19. Nearly one-third (45,628/146,191, 31.2%) of the conversations on COVID-19 vaccine hesitancy clusters expressed concerns for freedom or mistrust of institutions (either the government or multinational corporations) and nearly a quarter (34,756/146,191, 23.8%) expressed criticism toward the government’s handling of the pandemic.

Conclusions

Social media content analysis combined with social network analysis provides insights into the themes of the vaccination conversation on Twitter. The themes of safety, efficacy, and trust in institutions will need to be considered, as targeted outreach programs and intervention strategies are deployed on Twitter to improve the uptake of COVID-19 vaccination.
Cyberbullying Among Traditional and Complementary Medicine Practitioners in the Workplace: Protocol for a Cross-sectional Descriptive Study
Authors: Kim Yun Jin , Qian Linchao , Aslam Muhammad Shahzad
Published: August 2021

Background

Cyberbullying is becoming prevalent among health care professionals and may cause a variety of mental health issues. Traditional and complementary medicine practitioners remain an important pillar of the health care system in Malaysia.

Objective

This paper presents a study protocol for an online survey (Cyberbullying Among Traditional and Complementary Medicine Practitioner [TCMPs]) that will collect the first nationwide representative data on cyberbullying behavior among traditional and complementary medicine practitioners in Malaysia. The objectives of the survey are to (1) evaluate the cyberbullying behavior among traditional and complementary medicine practitioners in Malaysia, (2) identify sociodemographic and social factors related to cyberbullying, and (3) evaluate the association between cyberbullying behavior, sociodemographic, and social factors.

Methods

A snowball sampling strategy will be applied. Traditional and complementary medicine practitioners who are permanent Malaysian residents will be randomly selected and invited to participate in the survey (N=1023). Cyberbullying behavior will be measured using the Cyberbullying Behavior Questionnaire (CBQ). Data on the following items will be collected: work-related bullying, person-related bullying, aggressively worded messages, distortion of messages, sending offensive photos/videos, hacking computers or sending a virus or rude message, and threatening messages about personal life or family members. We will also collect data on participants’ sociodemographic characteristics, social factors, and substance abuse behavior.

Results

This cross-sectional descriptive study was registered with Research Registry (Unique Identifying Number 6216; November 05, 2020). This research work (substudy) is planned under a phase 1 study approved by the Research Management Centre, Xiamen University Malaysia. This substudy has been approved by the Research Ethics Committee of Xiamen University Malaysia (REC-2011.01). The cross-sectional survey will be conducted from July 01, 2021, to June 30, 2022. Data preparation and statistical analyses are planned from January 2022 onward.

Conclusions

The current research can contribute to identify the prevalence of workplace cyberbullying among Malaysian traditional and complementary medicine practitioners. The results will help government stakeholders, health professionals, and education professionals to understand the psychological well-being of Malaysian traditional and complementary medicine practitioners.

Trial Registration

Research Registry Unique Identifying Number 6216; https://tinyurl.com/3rsmxs7u

International Registered Report Identifier (IRRID)

PRR1-10.2196/29582
Examining the Effectiveness of 3D Virtual Reality Training on Problem-solving, Self-efficacy, and Teamwork Among Inexperienced Volunteers Helping With Drug Use Prevention: Randomized Controlled Trial
Authors: Chiang Chih-Huei , Huang Chiu-Mieh , Sheu Jiunn-Jye , Liao Jung-Yu , Hsu Hsiao-Pei , Wang Shih-Wen , Guo Jong-Long
Published: August 2021

Background

Illegal drug usage among adolescents is a critical health problem. The Taiwanese government provides an accompanying volunteer program to prevent students who experiment with drugs from reusing them. An appropriate training program can improve volunteers’ abilities to assist students using drugs. Problem-solving, self-efficacy, and teamwork are critical abilities for inexperienced volunteers who help with drug use prevention. By interacting with the animation or 3D virtual reality (VR) in the virtual scene, learners can immerse themselves in the virtual environment to learn, and 3D VR can increase learning opportunities and reduce the cost of human and material resources.

Objective

The aim of this study was to examine the effectiveness of spherical video-based virtual reality (SVVR) training in improving problem-solving, self-efficacy, and teamwork among volunteers who helped prevent adolescents from using illegal drugs.

Methods

This study used a randomized controlled design with a total of 68 participants in the experimental (n=35) and control (n=33) groups. The participants in the experimental group received the SVVR training program and their counterparts in the control group did not receive any training.

Results

Generalized estimating equation analyses indicated that the experimental group showed significant posttraining improvements in problem-solving and self-efficacy but not teamwork when compared with the control group.

Conclusions

The results of this study revealed that SVVR could improve participants’ problem-solving skills and self-efficacy for assisting students in not using illegal drugs. However, future studies are suggested to develop effective SVVR to assist inexperienced volunteers in enhancing their teamwork abilities. We believed that introducing the training program to more sites can enhance volunteer training so that volunteers can have a better companionship effect when helping students quit drugs.

Trial Registration

ClinicalTrials.gov NCT05072431; https://clinicaltrials.gov/ct2/show/NCT05072431
Factors Influencing the Popularity of a Health-Related Answer on a Chinese Question-and-Answer Website: Case Study
Authors: Li Jinhui , Zheng Han , Duan Xu
Published: August 2021

Background

Social question-and-answer (Q&A) sites have become an important venue for individuals to obtain and share human papillomavirus (HPV) vaccine knowledge.

Objective

This study aims to examine how different features of an HPV vaccine–related answer are associated with users’ response behaviors on social Q&A websites.

Methods

A total of 2953 answers and 270 corresponding questions regarding the HPV vaccine were collected from a leading Chinese social Q&A platform, Zhihu. Three types of key features, including content, context, and contributor, were extracted and coded. Negative binomial regression models were used to examine their impact on the vote and comment count of an HPV vaccine–related answer.

Results

The findings showed that both content length and vividness were positively related to the response behaviors of HPV vaccine–related answers. In addition, compared with answers under the question theme benefits and risks, answers under the question theme vaccination experience received fewer votes and answers under the theme news opinions received more votes but fewer comments. The effects of characteristics of contributors were also supported, suggesting that answers from a male contributor with more followers and no professional identity would attract more votes and comments from community members. The significant interaction effect between content and context features further showed that long and vivid answers about HPV vaccination experience were more likely to receive votes and comments of users than those about benefits and risks.

Conclusions

The study provides a complete picture of the underlying mechanism behind response behaviors of users toward HPV vaccine–related answers on social Q&A websites. The results help health community organizers develop better strategies for building and maintaining a vibrant web-based community for communicating HPV vaccine knowledge.
Cyberbullying Among Traditional and Complementary Medicine Practitioners in the Workplace: Protocol for a Cross-sectional Descriptive Study (Preprint)
Authors: Kim Yun Jin , Qian Linchao , Aslam Muhammad Shahzad
Published: August 2021

BACKGROUND

Cyberbullying is becoming prevalent among health care professionals and may cause a variety of mental health issues. Traditional and complementary medicine practitioners remain an important pillar of the health care system in Malaysia.

OBJECTIVE

This paper presents a study protocol for an online survey (Cyberbullying Among Traditional and Complementary Medicine Practitioner [TCMPs]) that will collect the first nationwide representative data on cyberbullying behavior among traditional and complementary medicine practitioners in Malaysia. The objectives of the survey are to (1) evaluate the cyberbullying behavior among traditional and complementary medicine practitioners in Malaysia, (2) identify sociodemographic and social factors related to cyberbullying, and (3) evaluate the association between cyberbullying behavior, sociodemographic, and social factors.

METHODS

A snowball sampling strategy will be applied. Traditional and complementary medicine practitioners who are permanent Malaysian residents will be randomly selected and invited to participate in the survey (N=1023). Cyberbullying behavior will be measured using the Cyberbullying Behavior Questionnaire (CBQ). Data on the following items will be collected: work-related bullying, person-related bullying, aggressively worded messages, distortion of messages, sending offensive photos/videos, hacking computers or sending a virus or rude message, and threatening messages about personal life or family members. We will also collect data on participants’ sociodemographic characteristics, social factors, and substance abuse behavior.

RESULTS

This cross-sectional descriptive study was registered with Research Registry (Unique Identifying Number 6216; November 05, 2020). This research work (substudy) is planned under a phase 1 study approved by the Research Management Centre, Xiamen University Malaysia. This substudy has been approved by the Research Ethics Committee of Xiamen University Malaysia (REC-2011.01). The cross-sectional survey will be conducted from July 01, 2021, to June 30, 2022. Data preparation and statistical analyses are planned from January 2022 onward.

CONCLUSIONS

The current research can contribute to identify the prevalence of workplace cyberbullying among Malaysian traditional and complementary medicine practitioners. The results will help government stakeholders, health professionals, and education professionals to understand the psychological well-being of Malaysian traditional and complementary medicine practitioners.

CLINICALTRIAL

Research Registry Unique Identifying Number 6216; https://tinyurl.com/3rsmxs7u

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/29582
The Feasibility and Acceptability of Delivering Pivotal Response Treatment for Autism Spectrum Disorder via Telehealth: A Pilot Study (Preprint)
Authors: Drapalik Krista Nicole , Grodberg David , Ventola Pamela
Published: August 2021

BACKGROUND

Pivotal Response Treatment (PRT), an evidence-based and parent-delivered intervention, is designed to improve social communication in individuals with autism spectrum disorder (ASD).

OBJECTIVE

To assess the feasibility, acceptability, and clinical effects of an online model of PRT delivered via MindNest Health that aims to provide self-directed and engaging online modules, real-time coaching and feedback, and accessible stepped-care to large populations of parents seeking resources for their children with ASD.

METHODS

Male and female children, ages 2-7 years old with single-word to phrase-level speech, were eligible to participate in the study. Families were randomized to the online parent training condition or control condition. The online component of the intervention consisted of eight 20-minute online courses of content describing parent training principles in PRT. Four 1-hour videoconferences were held after course 1, course 3, course 5, and course 8. Parents were given 1-2 weeks to complete each course. Parents completed the Client Expectancies Questionnaire (CCQ) at Week 2 and endpoint, as well as the Behavioral Intervention Rating Scale (BIRS) at endpoint to assess parental expectancies and treatment acceptability and effectiveness.

RESULTS

9 of 14 subjects completed the study curriculum in the online parent training condition, and 6 of 12 subjects completed the control condition. A total of 58% subjects completed study curriculum by study closure. Within the online parent training condition, there was a significant increase in mean CCQ Total Scores from 25.38 ± 3.25 at baseline to 27.5 ± 3.74 at endpoint (P = .04), mean CCQ Confidence Scores from 6.0 ± 1.07 at baseline to 6.75 ± 0.89 at endpoint (P = .02), and mean CCQ Other Improvement Scores 5.25 ± 0.89 at baseline to 6.25 ± 1.28 at endpoint (P = .009). Within the control condition, a modest increase in CCQ scores existed (Confidence △M = +.25; Recommend △M = +.25; Total Score △M = +.50), but no significant results were found (Confidence P = .38; Recommend P = .36; Total Score P = .43). Out of the eleven parents that completed the BIRS at endpoint, 83% parents endorsed they slightly agree or agree with over 93% of the Acceptability factor items on the BIRS.

CONCLUSIONS

The feasibility of this online treatment is endorsed by the high rate of online module completion and attendance to videoconferences within the online parent training group. Acceptability of treatment is supported by strong ratings on the CCQ and significant improvements in scores as well as strong ratings on the BIRS. This study’s small sample size limits the conclusions that can be drawn, however, the PRT MindNest Health platform holds promise to support parents of children with ASD who are unable to access traditional, in-person parent-mediated intervention for their child.