bluuebunny/crossref_metadata_2025 huggingface dataset:
Pre-Exercise Caffeine Intake Attenuates the Negative Effects of Ramadan Fasting on Several Aspects of High-Intensity Short-Term Maximal Performances in Adolescent Female Handball Players
Authors: Bougrine Houda , Nasser Nidhal , Abdessalem Raouf , Ammar Achraf , Chtourou Hamdi , Souissi Nizar
Published: August 2023

The aim of this investigation was to determine whether, after Ramadan, pre-exercise caffeine intake can reduce any possible negative effects of this month on short-term maximal performances in young female handball players. A randomized study involved thirteen young female handball players. Participants performed a squat jump (SJ), Illinois agility test (AG), and 5 m run shuttles test (total (TD) and peak (PD) distances) at 08:00 AM and 06:00 PM on three different occasions: one week before Ramadan (Pre-R), the last week of Ramadan (R), and the week after Ramadan (Post-R). A placebo (Pla) or caffeine (Caff) (6 mg·kg−1) was administered 60 min before exercise test sessions at two distinct times of day (08:00 AM and 06:00 PM) during the two periods: Pre and Post-R. The PSQI and dietary intake were assessed during all testing periods. The results revealed that Pre-R, (SJ, AG, TD, and PD) test performances were greater in the evening (PM) than in the morning (AM) (all p < 0.001). However, compared with Pre-R, PM performances declined significantly during R (all p < 0.001) and Post-R (p < 0.05, p < 0.01, p < 0.01 and p < 0.001, respectively). In addition, Pre-R, AM Caff produced moderate significant improvements compared with AM Pla, with small-to-no beneficial effects observed with PM Caff in SJ (4.8% vs. 1%), AG (1.8% vs. 0.8%), TD (2.8% vs. 0.3%), and PD (6% vs. 0.9%). Nevertheless, Caff produced moderate ergogenic effects during both AM and PM sessions during Post-R in SJ (4.4% vs. 2.4%), AG (1.7% vs. 1.5%), TD (2.9% vs. 1.3%), and PD (5.8% vs. 3%) with values approaching those of Pre-R Pla within the same time of day (p > 0.05, p > 0.05, p < 0.05, and p < 0.05, respectively). In summary, pre-exercise Caff intake with a dose equivalent to 6 mg·kg−1 reduced the negative effects of Ramadan fasting in several aspects of short-term maximal performances in young female handball players at both times of the day.
The Roles of Lipid Metabolism in the Pathogenesis of Chronic Diseases in the Elderly
Authors: Song Rui , Hu Mengxiao , Qin Xiyu , Qiu Lili , Wang Pengjie , Zhang Xiaoxu , Liu Rong , Wang Xiaoyu
Published: August 2023

Lipid metabolism plays crucial roles in cellular processes such as hormone synthesis, energy production, and fat storage. Older adults are at risk of the dysregulation of lipid metabolism, which is associated with progressive declines in the physiological function of various organs. With advancing age, digestion and absorption commonly change, thereby resulting in decreased nutrient uptake. However, in the elderly population, the accumulation of excess fat becomes more pronounced due to a decline in the body’s capacity to utilize lipids effectively. This is characterized by enhanced adipocyte synthesis and reduced breakdown, along with diminished peripheral tissue utilization capacity. Excessive lipid accumulation in the body, which manifests as hyperlipidemia and accumulated visceral fat, is linked to several chronic lipid-related diseases, including cardiovascular disease, type 2 diabetes, obesity, and nonalcoholic fatty liver disease. This review provides a summary of the altered lipid metabolism during aging, including lipid digestion, absorption, anabolism, and catabolism, as well as their associations with age-related chronic diseases, which aids in developing nutritional interventions for older adults to prevent or alleviate age-related chronic diseases.
Maternal n-7 Unsaturated Fatty Acids Protect the Fetal Brain from Neuronal Degeneration in an Intrauterine Hyperglycemic Animal Model
Authors: Okami Haruka , Kawaharada Ritsuko , Yoshizaki Hitomi , Toriumi Akiyo , Tsutsumi Saki , Nakamura Akio
Published: August 2023

We previously reported that glycation induces insulin resistance in the hearts of newborn pups from a gestational diabetes mellitus (GDM) rat model. Administration of n-3 unsaturated fatty acids suppressed glycation and improved signaling in GDM rat pups. In this study, we investigated their effects on cranial neurons using the GDM rat model and PC12 cells derived from rat adrenal pheochromocytomas. Additionally, we examined whether n-3 and n-7 unsaturated fatty acids (cis-palmitoleic acid [CPA] and trans-palmitoleic acid [TPA]) ameliorate the detrimental effects of high glucose exposure on rats. In the neonatal cerebrum of GDM rats, increased levels of advanced glycation end products (AGEs) inhibited Akt phosphorylation; however, CPA and TPA intake during pregnancy ameliorated these abnormalities. Furthermore, exposure to high-glucose-induced apoptosis in PC12 cells compared to the cells cultured in control glucose. PC12 cells exposed to high-glucose with fatty acids exhibited reduced AGE production and apoptosis induction compared to the high-glucose group. These findings suggest that a hyperglycemic environment during pregnancy promotes AGE formation in brain neuronal proteins and induces apoptosis. Both TPA and CPA mitigated these abnormalities; however, CPA is cytotoxic, highlighting its safety in pregnant women.
The Association between Macrosomia and Amino Acids’ Levels in Maternal and Cord Sera: A Case-Control Study
Authors: Xing Xinxin , Duan Yifan , Wang Ye , Wang Jie , Yang Zhenyu , Shao Lijun , Li Lin , Lai Jianqiang
Published: August 2023

This study aims to explore the relationship between macrosomia and amino acids in maternal and cord sera. Methods: In the case-control study, 78 pairs of mothers and newborns were recruited from December 2016 to November 2019. Participants were divided into the macrosomia group (BW ≥ 4000 g, n = 39) and the control group (BW between 2500 g and 3999 g, n = 39) according to the birth weight (BW) of newborns. Maternal vein blood samples were collected before delivery and cord vein blood samples were collected after birth. The levels of amino acids in maternal and cord sera were measured by liquid chromatography and mass spectrometry (LC-MS/MS) in the year 2021. The difference in amino acid levels in maternal and cord sera between the two groups was compared, and the contribution of each amino acid to the difference between the two groups was analyzed. Unconditional logistic regression analysis was used to test the relationship between macrosomia and amino acids. Results: In maternal serum during the antepartum, the levels of asparagine, glutamine, methionine, alanine, and threonine in the macrosomia group were higher but arginine was lower than that in the control group (p < 0.05). In cord serum, the levels of lysine, histidine, phenylalanine, arginine, tryptophan, valine, isoleucine, glutamate, tyrosine, and total essential amino acid (EAA) in the macrosomia group were lower while glutamine was higher than that in the control group (p < 0.05). The ratios of EAA, valine, threonine, methionine, tryptophan, and alanine in maternal serum to those in cord serum were higher, while the ratio of glutamine was lower in the macrosomia group (p < 0.05). Arginine and threonine in maternal serum and glutamate, glutamine, and histidine in cord serum were associated with macrosomia (p < 0.05). Conclusion: Most of the amino acid levels in the maternal sera of the macrosomia group are higher than those in the control group, while most of the amino acids’ levels in the cord sera of the macrosomia group are lower than those in the control group. The ratios of some amino acids in maternal serum to those in cord serum were different between the two groups. Arginine and threonine in maternal serum and glutamate, glutamine, and histidine in cord serum are closely related to macrosomia.
The Therapeutic Potential of Natural Dietary Flavonoids against SARS-CoV-2 Infection
Authors: Wang Zhonglei , Yang Liyan
Published: August 2023

The exploration of non-toxic and cost-effective dietary components, such as epigallocatechin 3-gallate and myricetin, for health improvement and disease treatment has recently attracted substantial research attention. The recent COVID-19 pandemic has provided a unique opportunity for the investigation and identification of dietary components capable of treating viral infections, as well as gathering the evidence needed to address the major challenges presented by public health emergencies. Dietary components hold great potential as a starting point for further drug development for the treatment and prevention of SARS-CoV-2 infection owing to their good safety, broad-spectrum antiviral activities, and multi-organ protective capacity. Here, we review current knowledge of the characteristics—chemical composition, bioactive properties, and putative mechanisms of action—of natural bioactive dietary flavonoids with the potential for targeting SARS-CoV-2 and its variants. Notably, we present promising strategies (combination therapy, lead optimization, and drug delivery) to overcome the inherent deficiencies of natural dietary flavonoids, such as limited bioavailability and poor stability.
HPV16 Impacts NHERF2 Expression in Oropharyngeal Cancers
Authors: Lulić Lucija , Jakovčević Antonia , Kovačić Iva , Manojlović Luka , Dediol Emil , Skelin Josipa , Tomaić Vjekoslav
Published: August 2023

Infection with human papillomaviruses (HPVs), in particular with HPV type 16, is now considered to be a key risk factor for the development of a subset of oropharyngeal squamous cell carcinomas (OPSCC) that show different epidemiological, clinical, and prognostic characteristics from HPV-negative (HPV−) OPSCCs. So far, extensive research efforts aiming to distinguish these two distinct entities have not identified specific biomarkers, nor led to different therapies. Previous research has shown that HPV16 E6 oncoprotein binds NHERF2, inducing its proteasomal degradation, and consequently increasing cell proliferation; we therefore aimed to investigate how this might be reflected in human histological samples. We analyzed NHERF2 expression patterns in HPV16-positive (HPV16+) and HPV− OPSCC samples, to investigate any potential differences in NHERF2 pattern. Interestingly, we observed a statistically significant decrease in NHERF2 levels in HPV16+ and poorly differentiated HPV− OPSCCs, compared with healthy tissue. Furthermore, we observed a significant reduction in the percentage of NHERF2 immunoreactive cancer cells in HPV16+ tumors, compared with well and moderately differentiated HPV− OPSCCs, suggesting the importance of 16E6’s targeting of NHERF2 in HPV-driven oncogenesis in the head and neck area.
Anti-Coccal Activity and Composition of the Essential Oils and Methanolic Extracts Obtained from Brewing Quality Humulus lupulus L. Hop Pellets
Authors: Piasecki Bartłomiej , Biernasiuk Anna , Ludwiczuk Agnieszka
Published: August 2023

This study examined the chemical composition and anti-coccal properties of essential oils and methanolic extracts of six different Humulus lupulus L. varieties from Poland: Iunga, Marynka, Sybilla, Magnum, Tradition and Chinook. The activity of an α-acid-enriched fraction of methanolic extracts was also studied. The chemical composition of essential oils and extracts was determined by gas chromatography–mass spectrometry (GC/MS) and liquid chromatography–mass spectrometry (LC/MS) techniques. The compounds characteristic to H. lupulus extracts include xanthohumol, α-acids, β-acids, and prenylated flavonoids. Essential oil compositions showed a high prevalence of monoterpene hydrocarbon, myrcene and sesquiterpene hydrocarbons, α-humulene and β-caryophyllene. The antimicrobial activity was investigated against eight human cocci pathogenic strains: Staphylococcus aureus MRSA (ATCC 43300), S. aureus MRSA (29213), S. aureus MSSA (ATCC 29213), S. epidermidis (ATCC 12228), Enterococcus faecalis (ATCC 29212), E. faecalis VRE (ATCC 51299), E. faecium (ATCC 19434) and Micrococcus luteus (ATCC 10240). The lowest minimum inhibitory concentrations (MIC) were obtained for extracts and essential oils from Iunga hop samples. Extracts were significantly more active than essential oils. The most susceptible strain to both essential oils and extracts was M. luteus, whilst the least susceptible was E. faecium. The antimicrobial activity correlated with a high concentration of xanthohumol of active extracts rather than with the content of α-acids. Xanthohumol showed considerable activity against MRSA with an MIC value of 3.9 µg/mL. The activity of the α-acid-enriched fraction was mediocre compared to the results of all extracts.
Synergistic Combination of Letrozole and Berberine in Ascorbic Acid-Stabilized AuNPs: A Promising Solution for Breast Cancer
Authors: Foudah Ahmed I. , Alam Aftab , Salkini Mohammad Ayman , Ross Samir A. , Kumar Piyush , Aldawsari Mohammed F. , Alqarni Mohammed H. , Sweilam Sherouk Hussein
Published: August 2023

Breast cancer is a deadly disease that affects countless women worldwide. The most conventional treatments for breast cancer, such as the administration of anticancer medications such as letrozole (LTZ), pose significant barriers due to the non-selective delivery and low bioavailability of cytotoxic drugs leading to serious adverse effects and multidrug resistance (MDR). Addressing these obstacles requires an innovative approach, and we propose a combined strategy that synergistically incorporates LTZ with berberine (BBR) into stabilised AuNPs coated with ascorbic acid (AA), known as LTZ-BBR@AA-AuNPs. The LTZ-BBR@AA-AuNPs, a novel combined drug delivery system, were carefully designed to maximise the entrapment of both LTZ and BBR. The resulting spherical nanoparticles exhibited remarkable efficiency in trapping these two compounds, with rates of 58% and 54%, respectively. In particular, the average hydrodynamic diameter of these nanoparticles was determined to be 81.23 ± 4.0 nm with a PDI value of only 0.286, indicating excellent uniformity between them. Furthermore, their zeta potential was observed to be −14.5 mV, suggesting high stability even under physiological conditions. The release profiles showed that after being incubated for about 24 h at pH levels ranging from acidic (pH = 5) to basic (pH = 7), the percentage released for both drugs ranged from 56–72%. This sustained and controlled drug release can reduce any negative side effects while improving therapeutic efficacy when administered directly to cancer. MDA-MB-231 cells treated with LTZ-BBR@AA-AuNPs for 48 h exhibited IC50 values of 2.04 ± 0.011 μg/mL, indicating potent cytotoxicity against cells. Furthermore, the nanoparticles demonstrated excellent stability throughout the duration of the treatment.
Protective Role of Vitamin K3 on SARS-CoV-2 Structural Protein-Induced Inflammation and Cell Death
Authors: Zhan Yixiong , Zha Duoduo , Lin Hongru , Mao Xianxian , Yang Lingyi , Huang Houda , He Zongnan , Zhou Sheng , Xu Fei , Qian Yisong , Liu Yu
Published: August 2023

The structure proteins of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), such as nucleocapsid protein (N protein) and envelop protein (E protein), are considered to be the critical pro-inflammatory factors in coronavirus disease 2019 (COVID-19). Vitamin K3 has been reported to exert an anti-inflammatory effect. In this study, we investigated the protective effects of vitamin K3 on SARS-CoV-2 N protein induced-endothelial activation and SARS-CoV-2 E protein induced-cell death in THP-1 cells. The results showed that vitamin K3 reduced N protein-induced monocyte adhesion, suppressed the expression of adhesion molecules, and decreased the mRNA levels of pro-inflammatory cytokines in HLMECs. We confirmed that the effects of vitamin K3 on endothelial activation may be related to the inhibition of the NF-κB signal pathway. In addition, vitamin K3 reversed E protein-induced pyroptosis, inhibited NLRP3/GSDMD signal pathway and reduced the mRNA expression of pro-inflammatory cytokines in THP-1 cells. Our results also showed the protective effects of vitamin K3 on the SARS-CoV-2 structural protein-induced THP-1 cells pyroptosis and endothelial activation via NF-κB signaling pathway. These findings suggested that vitamin K3 potently suppressed the inflammatory response to prevent endothelial activation and monocyte pyroptosis induced by SARS-CoV-2 proteins. This may provide a new strategy for the treatment of COVID-19.
The Use of an Inspiration-Synchronized Vibrating Mesh Nebulizer for Prolonged Inhalative Iloprost Administration in Mechanically Ventilated Patients—An In Vitro Model
Authors: Otto Matthias , Kropp Yannik , Jäger Evelyn , Neumaier Michael , Thiel Manfred , Quintel Michael , Tsagogiorgas Charalambos
Published: August 2023

Mechanically ventilated patients suffering from acute respiratory distress syndrome (ARDS) frequently receive aerosolized iloprost. Because of prostacyclin’s short half-life, prolonged inhalative administration might improve its clinical efficacy. But, this is technically challenging. A solution might be the use of inspiration-synchronized vibrating mesh nebulizers (VMNsyn), which achieve high drug deposition rates while showing prolonged nebulization times. However, there are no data comparing prolonged to bolus iloprost nebulization using a continuous vibrating mesh nebulizer (VMNcont) and investigating the effects of different ventilation modes on inspiration-synchronized nebulization. Therefore, in an in vitro model of mechanically ventilated adults, a VMNsyn and a VMNcont were compared in volume-controlled (VC-CMV) and pressure-controlled continuous mandatory ventilation (PC-CMV) regarding iloprost deposition rate and nebulization time. During VC-CMV, the deposition rate of the VMNsyn was comparable to the rate obtained with the VMNcont, but 10.9% lower during PC-CMV. The aerosol output of the VMNsyn during both ventilation modes was significantly lower compared to the VMNcont, leading to a 7.5 times longer nebulization time during VC-CMV and only to a 4.2 times longer nebulization time during PC-CMV. Inspiration-synchronized nebulization during VC-CMV mode therefore seems to be the most suitable for prolonged inhalative iloprost administration in mechanically ventilated patients.
Cu(ATSM) Increases P-Glycoprotein Expression and Function at the Blood-Brain Barrier in C57BL6/J Mice
Authors: Pyun Jae , Koay HuiJing , Runwal Pranav , Mawal Celeste , Bush Ashley I. , Pan Yijun , Donnelly Paul S. , Short Jennifer L. , Nicolazzo Joseph A.
Published: August 2023

P-glycoprotein (P-gp), expressed at the blood-brain barrier (BBB), is critical in preventing brain access to substrate drugs and effluxing amyloid beta (Aβ), a contributor to Alzheimer’s disease (AD). Strategies to regulate P-gp expression therefore may impact central nervous system (CNS) drug delivery and brain Aβ levels. As we have demonstrated that the copper complex copper diacetyl bis(4-methyl-3-thiosemicarbazone) (Cu(ATSM)) increases P-gp expression and function in human brain endothelial cells, the present study assessed the impact of Cu(ATSM) on expression and function of P-gp in mouse brain endothelial cells (mBECs) and capillaries in vivo, as well as in peripheral organs. Isolated mBECs treated with Cu(ATSM) (100 nM for 24 h) exhibited a 1.6-fold increase in P-gp expression and a 20% reduction in accumulation of the P-gp substrate rhodamine 123. Oral administration of Cu(ATSM) (30 mg/kg/day) for 28 days led to a 1.5 & 1.3-fold increase in brain microvascular and hepatic expression of P-gp, respectively, and a 20% reduction in BBB transport of [3H]-digoxin. A metallomic analysis showed a 3.5 and 19.9-fold increase in Cu levels in brain microvessels and livers of Cu(ATSM)-treated mice. Our findings demonstrate that Cu(ATSM) increases P-gp expression and function at the BBB in vivo, with implications for CNS drug delivery and clearance of Aβ in AD.
Effect of Gut Microbiota on the Pharmacokinetics of Nifedipine in Spontaneously Hypertensive Rats
Authors: Zhou Rong , Yang Haijun , Zhu Peng , Liu Yujie , Zhang Yanjuan , Zhang Wei , Zhou Honghao , Li Xiong , Li Qing
Published: August 2023

The pharmacokinetic variability of nifedipine widely observed in the clinic cannot be fully explained by pharmacogenomics. As a new factor affecting drug metabolism, how the gut microbiota affects the pharmacokinetics of nifedipine needs to be explored. Spontaneously hypertensive rats (SHRs) have been commonly used in hypertension-related research and served as the experimental groups; Wistar rats were used as control groups. In this study, the bioavailability of nifedipine decreased by 18.62% (p < 0.05) in the SHRs compared with the Wistar rats. Changes in microbiota were associated with the difference in pharmacokinetics. The relative abundance of Bacteroides dorei was negatively correlated with AUC0–t (r = −0.881, p = 0.004) and Cmax (r = −0.714, p = 0.047). Analysis of serum bile acid (BA) profiles indicated that glycoursodeoxycholic acid (GUDCA) and glycochenodeoxycholic acid (GCDCA) were significantly increased in the SHRs. Compared with the Wistar rats, the expressions of CYP3A1 and PXR were upregulated and the enzyme activity of CYP3A1 increased in the SHRs. Spearman’s rank correlation revealed that Bacteroides stercoris was negatively correlated with GUDCA (r = −0.7126, p = 0.0264) and GCDCA (r = −0.6878, p = 0.0339). Moreover, GUDCA was negatively correlated with Cmax (r = −0.556, p = 0.025). In primary rat hepatocytes, GUDCA could induce the expressions of PXR target genes CYP3A1 and Mdr1a. Furthermore, antibiotic treatments in SHRs verified the impact of microbiota on the pharmacokinetics of nifedipine. Generally, gut microbiota affects the pharmacokinetics of nifedipine through microbial biotransformation or by regulating the enzyme activity of CYP3A1.
Solanum aethiopicum L. from the Basilicata Region Prevents Lipid Absorption, Fat Accumulation, Oxidative Stress, and Inflammation in OA-Treated HepG2 and Caco-2 Cell Lines
Authors: Lela Ludovica , Russo Daniela , De Biasio Filomena , Gorgoglione Domenico , Ostuni Angela , Ponticelli Maria , Milella Luigi
Published: August 2023

Obesity is widely associated with intestine barrier impairment, nonalcoholic fatty liver disease (NAFLD) outbreaks, oxidative stress, and inflammation. In a previous investigation, the Solanum aethiopicum L. growing in Basilicata Region has demonstrated to have antioxidant activity; hence this investigation was aimed to evaluate for the first time the antilipidemic and anti-inflammatory activity of the Lucanian S. aethiopicum L. peel extract in vitro on OA-treated HepG2 and Caco-2 cell lines. It was shown that the extract could reduce lipogenesis by down-regulating SREBP-1c and HMGCR expression and fatty acid β-oxidation by up-regulating PPARα, CPT1A, and UCP2 expression. In addition, the S. aethiopicum L. peel extract might also improve oxidative stress by reducing endoplasmic reticulum stress and regulating the Nrf2 and Nf-κB molecular pathways. Altogether, these results demonstrated for the first time the possible application of the Lucanian S. aethiopicum peel extract for preventing obesity and managing NAFLD.
Phytochemistry, Biological, and Pharmacological Properties of Abies alba Mill.
Authors: Ancuceanu Robert , Hovaneț Marilena Viorica , Miron Anca , Anghel Adriana Iuliana , Dinu Mihaela
Published: August 2023

Abies alba Mill. (Pinaceae), silver fir, is a widespread gymnosperm species in Europe, important for its ecological, economic, social, and cultural significance, as well as for its use for food and bioremediation purposes. The various parts of the plant (leaves, branches, cones, wood, bark) are also of pharmaceutical interest due to their composition of active compounds. In the last three decades, an impressive amount of research has been dedicated to this species. The variability of the chemical composition of essential oils (whether they come from leaves, oleoresin from branches, or other parts of the plant) is impressive, even in the case of specimens collected from the same geographical area. For essential oils prepared from needles or twigs and branches, limonene, β-pinene, α-pinene, camphene, β-phellandrene, and bornyl acetate are the leading compounds, although their wide variations seem to correspond to multiple chemotypes. Both bark and wood are rich in lignans and phenolic compounds. Matairesinol is apparently the dominant lignan in bark, and secoisolariciresinol and lariciresinol are the dominant ones in wood samples. Pharmacological studies with promising results have evaluated the antioxidant effect (mainly due to essential oils), but also the antimicrobial, antitumor, probiotic, antidiabetic, anti-steatosis, and anti-psoriatic activities.
Comparative Analysis of Physicochemical Properties and Storability of a New Citrus Variety, Yellowball, and Its Parent
Authors: Kim Dong-Shin , Jeong Sung-man , Jo Seong-Ho , Chanmuang Saoraya , Kim Sang Suk , Park Suk Man , Yun Su Hyun , Han Seung-Gab , Cho Jeong-Yong , Kang Inhae , Kim Hyun-Jin
Published: August 2023

Although numerous citrus varieties have recently been developed to enhance their quality, information on their quality characteristics is limited. We assessed the quality characteristics of Yellowball, a novel citrus variety, by evaluating its appearance, storability, sensory properties, functionality, and metabolite profiles and then comparing these characteristics with those of its parent varieties, Haruka and Kiyomi. The metabolite profiles between the citrus varieties differed significantly, resulting in distinct physicochemical and functional qualities. The storability of Yellowball was significantly increased compared with that of its parent varieties owing to its strong antifungal activity and unique peel morphology, including the stoma and albedo layers. While we did not investigate the volatile compounds, overall functional activities, and detailed characteristics of each metabolite, our data provide valuable insights into the relationship between citrus metabolites, peel morphology, physicochemical properties, and storability, and demonstrate the potential of Yellowball as a promising variety in the citrus industry.
Effects of Friction Stir Welding on the Mechanical Behaviors of Extrusion-Based Additive Manufactured Polymer Parts
Authors: Liu Jin-Feng , Zhou Ying-Guo , Chen Shu-Jin , Ren Shao-Qiang , Zou Jun
Published: August 2023

The friction stir welding (FSW) of thermoplastic polymers is gradually receiving attention because of its advantages including high efficiency and pollution-free manufacturing. The extrusion-based additive manufacturing (EAM) of polymers has also become one of the main processing methods for thermoplastic parts. In this paper, a hybrid manufacturing method for the FSW process and EAM technology is proposed and explored. The effects of the FSW process using two different welding tools on the mechanical behaviors of 3D printing polymer parts were compared and investigated and the corresponding mechanism was analyzed. The results show that the appropriate welding tool is beneficial for eliminating the anisotropy and decreasing the porosity of 3D-printed parts. Therefore, the improving effects of the FSW process on the mechanical behaviors of the EAM parts are verified. The mechanism was attributed to the high-speed rotation of the welding tool with the appropriate shape, which can promote the flow of polymer melt in the welding region, leading to the formation of dense structures caused by the entanglement of the molecular chains. This study may provide some assistance in modern industrial manufacturing for the processing of large custom components.
Antibacterial Effect of Polyvinyl Alcohol/Biochar–Nano Silver/Sodium Alginate Gel Beads
Authors: Xie Licheng , Zhang Zhichao , He Yucai
Published: August 2023

To date, biochar bacteriostatic material has attracted much attention from researchers. The compact porous structure of fish-scale biochar provides good application prospects. In this study, silver-carrying biochar–polyvinyl alcohol–alginate gel beads (C/PVA/SA) were designed for suppressing bacteria. The biochar was loaded with nano silver particles as the filler, alginate as the substrate, and polyvinyl alcohol (PVA) as the additive to enhance the mechanical properties. The composite gel beads were characterized using Fourier-transform infrared spectrometry (FT-IR). The results indicated that adjusting the PVA concentration could retain the bacteriostatic performance of the gel beads in different pH value solutions. It was found that C/PVA/SA gel beads had a strong inhibitory effect on Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. After ten consecutive antibacterial tests, the antibacterial rate remained high (above 99%) for 15 days. The adhesive effect of SA and PVA resulted in a tight spatial structure of the gel beads. The C/PVA/SA gel composition could effectively prevent water loss and enhance the shrinkage ability of the gel beads. The good degradation performance of C/PVA/SA was also in line with the concept of environmental protection. In general, the C/PVA/SA gel beads showed high potential for application in the treatment of microbial contamination and environmental protection.
Coal Pillar Size Determination and Surrounding Rock Control for Gob-Side Entry Driving in Deep Soft Coal Seams
Authors: Jiang Zaisheng , Guo Wenke , Xie Shengrong
Published: August 2023

In response to the large-scale instability failure problem of designing coal pillars and support systems for gob-side entry driving (GSED) in high-stress soft coal seams in deep mines, the main difficulties in the surrounding rock control of GSED were analyzed. The relationship between the position of the main roof breaking line, together with the width of the limit equilibrium zone and a reasonable size for the coal pillar, were quantified through theoretical calculations. The theoretical calculations showed that the maximum and minimum widths of the coal pillar are 8.40 m and 5.47 m, respectively. A numerical simulation was used to study the distribution characteristics and evolution laws of deviatoric stress and plastic failure fields in the GSED surrounding rock under different coal pillar sizes. Theoretical analysis, numerical simulation, and engineering practice were comprehensively applied to determine a reasonable size for narrow coal pillars for GSED in deep soft coal seams, which was 6.5 m. Based on the 6.5 m coal pillar size, the distribution of deviatoric stress and plastic zones in the surrounding rock of the roadway, at different positions of the advanced panel during mining, was simulated, and the range of roadway strengthening supports for the advanced panel was determined as 25 m. The plasticization degree of the roof, entity coal and coal pillar, and the boundary line position of the peak deviatoric stress zone after the stability of the excavation were obtained. Drilling crack detection was conducted on the surrounding rock of the GSED roof and rib, and the development range and degree of the crack were obtained. The key areas for GSED surrounding rock control were clarified. Joint control technology for surrounding rock is proposed, which includes a combination of a roof channel steel anchor beam mesh, a rib asymmetric channel steel truss anchor cable beam mesh, a grouting modification in local fractured areas and an advanced strengthening support with a single hydraulic support. The engineering practice showed that the selected 6.5 m size for narrow coal pillars and high-strength combined reinforcement technology can effectively control large deformations of the GSED surrounding rock.
Remaining Useful Life Prediction for Lithium-Ion Batteries Based on a Hybrid Deep Learning Model
Authors: Chen Chao , Wei Jie , Li Zhenhua
Published: August 2023

Lithium-ion batteries are widely utilized in various fields, including aerospace, new energy vehicles, energy storage systems, medical equipment, and security equipment, due to their high energy density, extended lifespan, and lightweight design. Precisely predicting the remaining useful life (RUL) of lithium batteries is crucial for ensuring the safe use of a device. In order to solve the problems of unstable prediction accuracy and difficultly modeling lithium-ion battery RUL with previous methods, this paper combines a channel attention (CA) mechanism and long short-term memory networks (LSTM) to propose a new hybrid CA-LSTM lithium-ion battery RUL prediction model. By incorporating a CA mechanism, the utilization of local features in situations where data are limited can be improved. Additionally, the CA mechanism can effectively mitigate the impact of battery capacity rebound on the model during lithium-ion battery charging and discharging cycles. In order to ensure the full validity of the experiments, this paper utilized the National Aeronautics and Space Administration (NASA) and the University of Maryland Center for Advanced Life Cycle Engineering (CALCE) lithium-ion battery datasets and different prediction starting points for model validation. The experimental results demonstrated that the hybrid CA-LSTM lithium-ion battery RUL prediction model proposed in this paper exhibited a strong predictive performance and was minimally influenced by the prediction starting point.
Special Issue on “Extraction Optimization Processes of Antioxidants”
Authors: Cossignani Lina , Blasi Francesca
Published: August 2023

Understanding the importance of extraction optimization processes of bioactive molecules in the food industry is fundamental in the choice of innovative extraction processes involving sustainable procedures and is essential in process design for the isolation of antioxidants, thus preserving their chemical integrity and biological properties [...]
Source and Accumulation Process of Deep-Seated Oil and Gas in the Eastern Belt around the Penyijingxi Sag of the Junggar Basin, NW China
Authors: Qu Jiangxiu , Zhang Qinglan , Hou Maoguo , Ding Xiujian , Ablimit Imin
Published: August 2023

A breakthrough has been made in the recent exploration of the deep oil and gas bearing system in the eastern belt around the Penyijingxi sag of the Junggar Basin. These reservoirs are characterized by mixed sources and multi-stage accumulation. However, this process has not been thoroughly investigated, limiting our understanding of the fundamental rules of hydrocarbon migration and accumulation and making it difficult to determine exploration plans. This study mainly reconstructs this process using biomarkers, carbon isotopes, light hydrocarbons, and fluid inclusions. According to the biomarkers and carbon isotopes for oil-source correlation, Permian crude oil is a mixed-source oil from the Fengcheng Formation (P1f) and the Xiawuerhe Formation (P2w) source rocks, while Jurassic crude oil originates from the P2w source rock. The carbon isotope and light hydrocarbon data demonstrate that Jurassic natural gas has a mixed-gas characteristic with a preponderance of coal-type gas, in contrast to Permian natural gas, which is primarily oil-type gas. The hydrocarbon charging events in the study area were reconstructed based on a comprehensive investigation of the hydrocarbon generation history of source rocks, the homogenization temperature of fluid inclusion, and the burial history of the reservoir. According to the model, the P1f and P2w source rocks have made contributions to the current regional oil reservoirs, which provides targets for future exploration.
Thermodynamic Analysis of Hydrogen Production from Bio-Oil Steam Reforming Utilizing Waste Heat of Steel Slag
Authors: Ding Zhijun , Liu Yang , Yao Xin , Xue Yuekai , Li Chenxiao , Li Zhihui , Wang Shuhuan , Wu Jianwei
Published: August 2023

(1) Background: The discharged temperature of steel slag is up to 1450 °C, representing heat having a high calorific value. (2) Motivation: A novel technology, integrating bio-oil steam reforming with waste heat recovery from steel slag for hydrogen production, is proposed, and it is demonstrated to be an outstanding method via thermodynamic calculation. (3) Methods: The equilibrium productions of bio-oil steam reforming in steel slag under different temperatures and S/C ratios (the mole ratio of steam to carbon) are obtained by the method of minimizing the Gibbs free energy using HSC 6.0. (4) Conclusions: The hydrogen yield increases first and then decreases with the increasing temperature, but it increases with the increasing S/C. Considering equilibrium calculation and actual application, the optimal temperature and S/C are 706 °C and 6, respectively. The hydrogen yield and hydrogen component are 109.13 mol/kg and 70.21%, respectively, and the carbon yield is only 0.08 mol/kg under optimal conditions. Compared with CaO in steel slag, iron oxides have less effect on hydrogen production from bio-oil steam reforming in steel slag. The higher the basicity of steel slag, the higher the obtained hydrogen yield and hydrogen component of bio-oil steam reforming in steel slag. It is demonstrated that appropriately decreasing iron oxides and increasing basicity could promote the hydrogen yield and hydrogen component of bio-oil steam reforming that utilizes steel slag as a heat carrier during the industrial application.
Mythoi, Monomyth, and a Missing Mother: The Archetypal Significance of the Prodigal’s Quest in Luke 15:11–24
Authors: Dutko Joseph Lee
Published: August 2023

The parable of the Prodigal Son in Luke 15 elicits profound responses and emotions in various times, places, and cultures. Why has it stood the test of time as one of Jesus’ most famous parables? One possible answer is that the story carries enduring appeal because of the underlying structure of the parable, a recurring pattern in literature called the monomyth. Peeling back the layers of the parable, one may uncover the foundational archetypes of the parable that make it timeless. Hidden significance of the parable may be illuminated by comparing its narrative to the hero quest of Joseph Campbell and the monomyth archetypes of Northrop Frye and Leland Ryken, both of which emphasize a cyclical movement that unifies all of literature. Also important are the specific archetypes within the general monomyth archetype, such as father and mother, bread and water. The parable also contains the four elements (mythoi) of the circular monomyth: romance, tragedy, anti-romance, and comedy. Using archetypal and myth criticism, this article demonstrates that the parable has enduring attraction because its underlying archetypes appeal to a deep layer of the human psyche and to what is elemental to the human experience.
Spiritual Exercises and the Question of Religion in the Work of Pierre Hadot
Authors: Sharpe Matthew
Published: August 2023

This paper addresses John M. Cooper’s critique, and related critiques, of Pierre Hadot’s conception of philosophy as a way of life for collapsing the distinction between philosophy and religion, via the category of “spiritual exercises”. The paper has two parts. Part 1, a pars destruens, will show how Hadot presents three cogent rebuttals of these charges, with which he was familiar as early as the 1980s, following the publication of the first edition of his 1981 collection, Exercises spirituels et philosophie antique. In part 2, a pars construens, putting aside the vexed category of “religion”, we will examine how Hadot reconsiders the place of the sacred in ancient philosophy, positioning the latter as not the attempt to rationally dispel any sense of the sacred in the world, but to relocate it from within the sanctioned cultic places and temples of traditional Greco-Roman religion to within the inner life of the godlike sage.
Monitoring Spartina alterniflora Expansion Mode and Dieback Using Multisource High-Resolution Imagery in Yancheng Coastal Wetland, China
Authors: Yan Dandan , Luan Zhaoqing , Li Jingtai , Xie Siying , Wang Yu
Published: August 2023

Spartina alterniflora (smooth cordgrass), China’s most common invasive species, has posed significant challenges to native plant communities and coastal environments. Monitoring the invasion and dieback process of S. alterniflora by multisource high-resolution imagery is necessary to manage the invasion of the species. Current spatial analyses, however, are insufficient. As a result, we first extracted S. alterniflora by integrating multisource high-resolution images through the multiscale object-oriented classification method, then identified the expansion patterns of S. alterniflora on the seaward side by the landscape expansion index, and conformed the main drivers of S. alterniflora dieback on the landward side in the Jiangsu Dafeng Milu National Nature Reserve. The findings revealed that the area of S. alterniflora decreased in size from 1511.26 ha in 2010 to 910.25 ha in 2020. S. alterniflora continues to grow to the sea and along the tidal creek on the seaward side, with a total increase of 159.13 ha. External isolation expansion patterns accounted for 65.16% of the total expansion patches, with marginal expansion patches accounting for 24.22% and tidal creek-leading expansion patches accounting for 10.62%. While the landward side showed a declining trend, the total area decreased by 852.36 ha, with an annual average change rate of 8.67%. S. alterniflora dieback was negatively related to the number of tidal creeks and positively related to the number of wild Elaphures davidianus and the length of artificial ditches. Our findings provide a scientific foundation for the ecological control of S. alterniflora. Its presence in coastal wetlands inspires evidence-based protection and management strategies to protect the coastal wetland ecosystem.
Highly Efficient Anchor-Free Oriented Small Object Detection for Remote Sensing Images via Periodic Pseudo-Domain
Authors: Wang Minghui , Li Qingpeng , Gu Yunchao , Pan Junjun
Published: August 2023

With the continuous progress of remote sensing image object detection tasks in recent years, researchers in this field have gradually shifted the focus of their research from horizontal object detection to the study of object detection in arbitrary directions. It is worth noting that some properties are different from horizontal object detection during oriented object detection that researchers have yet to notice much. This article presents the design of a straightforward and efficient arbitrary-oriented detection system, leveraging the inherent properties of the orientation task, including the rotation angle and box aspect ratio. In the detection of low aspect ratio objects, the angle is of little importance to the orientation bounding box, and it is even difficult to define the angle information in extreme categories. Conversely, in the detection of objects with high aspect ratios, the angle information plays a crucial role and can have a decisive impact on the quality of the detection results. By exploiting the aspect ratio of different targets, this letter proposes a ratio-balanced angle loss that allows the model to make a better trade-off between low-aspect ratio objects and high-aspect ratio objects. The rotation angle of each oriented object, which we naturally embed into a two-dimensional Euclidean space for regression, thus avoids an overly redundant design and preserving the topological properties of the circular space. The performance of the UCAS-AOD, HRSC2016, and DLR-3K datasets show that the proposed model in this paper achieves a leading level in terms of both accuracy and speed.
Characterization and Analysis of Landslide Evolution in Intramountain Areas in Loja (Ecuador) Using RPAS Photogrammetric Products
Authors: Zárate Belizario A. , El Hamdouni Rachid , Fernández del Castillo Tomás
Published: August 2023

This case study focuses on the area of El Plateado near the city of Loja, Ecuador, where landslides with a high impact on infrastructures require monitoring and control. The main objectives of this work are the characterization of the landslide and the monitoring of its kinematics. Four flights were conducted using a remotely piloted aerial vehicle (RPAS) to capture aerial images that were processed with SfM techniques to generate digital elevation models (DEMs) and orthoimages of high resolution (0.05 m) and sufficient accuracy (below 0.05 m) for subsequent analyses. Thus, the DEM of differences (DoD) and profiles are obtained, but a morphometric analysis is conducted to quantitatively characterize the landslide’s elements and study its evolution. Parameters such as slope, aspect, topographic position index (TPI), terrain roughness index (TRI), and topographic wetness index (TWI) are analyzed. The results show a higher slope and roughness for scarps compared to stable areas and other elements. From TPI, slope break lines have been extracted, which allow the identification of landslide features such as scarps and toe tip. The landslide shows important changes in the landslide body surface, the retraction of the main scarp, and advances of the foot. A general decrease in average slope and TRI and an increase in TWI are also observed due to the landslide evolution and stabilization. The presence of fissures and the infiltration of rainfall water in the unsaturated soil layers, which consist of high-plasticity clays and silts, contribute to the instability. Thus, the study provides insights into the measurement accuracy, identification and characterization of landslide elements, morphometric analysis, landslide evolution, and the relationship with geotechnical factors that contribute to a better understanding of landslides. A higher frequency of the RPAS surveys and quality of geotechnical and meteorological data are required to improve the instability analysis together with a major automation of the GIS procedures.
The Impacts of Climate and Human Activities on Grassland Productivity Variation in China
Authors: Xue Yayong , Liang Haibin , Ma Yuanyuan , Xue Guoxuan , He Jia
Published: August 2023

Grassland degradation is widespread and increasing globally, which is closely related to the sustainable development of the ecosystems and the well-being of human life in pastoral areas. Quantifying the factors influencing grassland ecosystems, specifically climate change and human activities, is of great significance for grassland restoration. However, due to the unpredictability of human activities, further research is still needed to distinguish and identify the factors affecting grasslands. In this study, we examined the changes in the gross primary productivity (GPP) of grassland cover in 10 provinces (autonomous regions) of China from 2000 to 2018 and selected three representative climate factors (temperature, precipitation, solar radiation) and six factors covering socioeconomic (primary industry production and population), animal husbandry (large livestock and sheep populations), and national policies (grazing areas, rodent, and pest control) to characterize human activities; then, we quantified the effects and contribution of climate and human factors using three analysis methods (partial correlation analysis, geographical and temporal weighted regression model, and Lindeman Merenda Gold method). The results indicated that the GPP of grassland presented an obvious uptrend (4.75 g C m−2 yr−1, p < 0.05). Among the nine factors, sheep, precipitation, and temperature were the primary factors affecting grassland dynamics. Additionally, the GPP dynamics of grassland were mainly dominated by human activities in seven provinces (autonomous regions). These findings provide decision support for protecting grassland ecosystems and implementing ecological restoration policies in China.