bluuebunny/crossref_metadata_2025 huggingface dataset:
Anthraquinones: Genotoxic until Proven Otherwise? A Study on a Substance-Based Medical Device to Implement Available Data for a Correct Risk Assessment
Authors: Cocchi Veronica , Gasperini Sofia , Lenzi Monia
Published: March 2022

A genotoxicological study was carried out on a substance-based medical device (SMD) containing anthraquinones in order to evaluate its potential mutagenic effect. The “In Vitro Mammalian Cell Micronucleus Test” was performed on human TK6 cells by flow cytometry. Cultures were treated with concentrations of SMD tested in the range of 0–2 mg/mL for short treatment time (3 h) both in the absence and presence of an exogenous metabolic activation system, followed by a recovery period in fresh medium (23 h) and for extended treatment time (26 h) without an exogenous metabolic activation system. At the end of both treatment times, cytotoxicity, cytostasis, apoptosis and micronuclei (MNi) frequency were analysed in treated cultures and then compared with those measured in concurrent negative control cultures. The SMD did not induce a statistically significant increase MNi frequency under any of experimental conditions tested. The negative outcome shows that the SMD is non-mutagenic in terms of its ability to induce chromosomal aberrations both in the absence and presence of an exogenous metabolic activation system. The study ended by analyzing intracellular ROS levels to exclude the pro-oxidant ability, typically linked to DNA damage. On the contrary, our results demonstrated the ability the SMD to counteract oxidative stress.
Analysis of Active Compounds Using Target Protein Cofilin―Cucurbitacins in Cytotoxic Plant Bryonia cretica
Authors: Nakashima Souichi , Oda Yoshimi , Morita Moeko , Ohta Ayako , Morikawa Toshio , Matsuda Hisashi , Nakamura Seikou
Published: March 2022

We examined a two-step target protein binding strategy that uses cofilin as the target protein to analyze the active constituents in Bryonia cretica. In the first step, we prepared the target protein, and used it to analyze the compounds binding to it in the second step. We used the methanolic extract of B. cretica as a library of possible active compounds. We conducted LC–MS analysis using information from our previous study. The peaks in the HPLC profile were identified as cucurbitacin D, isocucurbitacin D, and cucurbitacin I. As far as we know, there is no known study of the activity of isocucurbitacin D in this research field. Therefore, we examined the effects of isocucurbitacin D on cell proliferation and cofilin protein in human fibrosarcoma cell line HT1080 to confirm the effectiveness of this strategy. The cytotoxicity assay, the fibrous/globular actin ratio assay, and the immunoblotting analysis revealed that isocucurbitacin D showed a cytotoxic effect with disruption of target protein cofilin. The target protein binding strategy is a direct and straightforward method for finding new drug seeds from crude sources, such as natural plant extracts.
Assessment of Common Cyanotoxins in Cyanobacteria of Biological Loess Crusts
Authors: Dulić Tamara , Svirčev Zorica , Palanački Malešević Tamara , Faassen Elisabeth J. , Savela Henna , Hao Qingzhen , Meriluoto Jussi
Published: March 2022

Cyanotoxins are a diverse group of bioactive compounds produced by cyanobacteria that have adverse effects on human and animal health. While the phenomenon of cyanotoxin production in aquatic environments is well studied, research on cyanotoxins in terrestrial environments, where cyanobacteria abundantly occur in biocrusts, is still in its infancy. Here, we investigated the potential cyanotoxin production in cyanobacteria-dominated biological loess crusts (BLCs) from three different regions (China, Iran, and Serbia) and in cyanobacterial cultures isolated from the BLCs. The presence of cyanotoxins microcystins, cylindrospermopsin, saxitoxins, and β-N-methylamino-L-alanine was analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) method, while the presence of cyanotoxin-encoding genes (mcyE, cyrJ, sxtA, sxtG, sxtS, and anaC) was investigated by polymerase chain reaction (PCR) method. We could not detect any of the targeted cyanotoxins in the biocrusts or the cyanobacterial cultures, nor could we amplify any cyanotoxin-encoding genes in the cyanobacterial strains. The results are discussed in terms of the biological role of cyanotoxins, the application of cyanobacteria in land restoration programs, and the use of cyanotoxins as biosignatures of cyanobacterial populations in loess research. The article highlights the need to extend the field of research on cyanobacteria and cyanotoxin production to terrestrial environments.
Special Issue: Host Cell–Virus Interaction
Authors: Mukherjee Anupam , Bagchi Parikshit
Published: March 2022

As rightly put by Nobel Laureate Joshua Lederberg, “the single biggest threat to man’s continued dominance on the planet is the Virus” [...]
A Renewed Appreciation of Helicoverpa armigera Nucleopolyhedrovirus BJ (Formerly Helicoverpa assulta Nucleopolyhedrovirus) with Whole Genome Sequencing
Authors: Zhao Lulu , Liu Xingjian , Tang Kai , Zhang Zhifang , Zhang Huan , Li Yinü
Published: March 2022

Helicoverpa assulta is a pest that causes severe damage to tobacco, pepper and other cash crops. A local strain of HearNPV-BJ (formerly Helicoverpa assulta nucleopolyhedrovirus (HeasNPV-DJ0031)) was isolated from infected H. assulta larvae in Beijing, which had been regarded as a new kind of baculovirus in previous studies. Describing the biological characteristics of the strain, including its external morphology, internal structure and the pathological characteristics of the infection of various cell lines, can provide references for the identification and function of the virus. HearNPV-BJ virion was defined as a single-nucleocapsid nucleopolyhedrovirus by scanning electron microscopy. QB-Ha-E-5 (H. armigera) and BCIRL-Hz-AM1 (H. zea) cell lines were sensitive to HearNPV-BJ. Undoubtedly modern developed sequencing technology further facilitates the increasing understanding of various strains. The whole genome sequence of the HearNPV-BJ was sequenced and analyzed. The HearNPV-BJ isolate genome was 129, 800 bp nucleotides in length with a G + C content of 38.87% and contained 128 open reading frames (ORFs) encoding predicted proteins of 50 or over 50 amino acids, 67 ORFs in the forward orientation and 61 ORFs in the reverse orientation, respectively. The genome shared 99% sequence identity with Helicoverpa armigera nucleopolyhedrovirus C1 strain (HearNPV-C1), and 103 ORFs had very high homology with published HearNPV sequences. Two bro genes and three hrs were found to be dispersed along the HearNPV-BJ genome. Three of the highest homologs, ORFs with HearNPV, were smaller due to the earlier appearance of the stop codon with unknown functions. P6.9 of HearNPV-BJ, a structural protein, is distinctly different from that of Autographa californica nucleopolyhedrovirus (AcMNPV); its homology with the corresponding gene in HearNPV-C1 was 93.58%. HearNPV-BJ contains 38 core genes identified in other baculoviruses, and phylogenetic analysis indicates HearNPV-BJ belongs to Alphabaculovirus Group II, same as HearNPV-C1. The resulting data provide a better understanding of virion structure, gene function and character of infection. By supplementing the whole-genome sequencing data and Kimura-2 model index, there is more evidence to indicate that HearNPV-BJ may be a variant of Helicoverpa armigera nucleopolyhedrovirus, which also deepens our understanding of the virus species demarcation criteria.
How to Motivate SARS-CoV-2 Convalescents to Receive a Booster Vaccination? Influence on Vaccination Willingness
Authors: Kowalski Elias , Stengel Andreas , Schneider Axel , Goebel-Stengel Miriam , Zipfel Stephan , Graf Johanna
Published: March 2022

(1) Background: Booster vaccinations for SARS-CoV-2 convalescents are essential for achieving herd immunity. For the first time, this study examined the influencing factors of vaccination willingness among SARS-CoV-2 infected individuals and identified vaccination-hesitant subgroups. (2) Methods: Individuals with positive SARS-CoV-2 PCR results were recruited by telephone. They completed an online questionnaire during their home isolation in Germany. This questionnaire assessed the vaccination willingness and its influencing factors. (3) Results: 224 home-isolated individuals with acute SARS-CoV-2 infection were included in the study. Vaccination willingness of home-isolated SARS-CoV-2 infected individuals with asymptomatic or moderate course was 54%. The following factors were associated with significantly lower vaccination willingness: younger age, foreign nationality, low income, low trust in vaccination effectiveness, fear of negative vaccination effects, low trust in the governmental pandemic management, low subjective informativeness about SARS-CoV-2, support of conspiracy theories. (4) Conclusions: The vaccination willingness of home-isolated SARS-CoV-2 infected individuals with asymptomatic or moderate symptomatic course was low. Motivational vaccination campaigns should be adapted to individuals with acute SARS-CoV-2 infection and consider the vaccination-hesitant groups. Vaccination education should be demand-driven, low-threshold, begin during the acute infection phase, and be guided for example by the established 5C model (“confidence, complacency, constraints, calculation, collective responsibility”).
Potential Antiviral Activity of Lactiplantibacillus plantarum KAU007 against Influenza Virus H1N1
Authors: Rather Irfan A. , Kamli Majid Rasool , Sabir Jamal S. M. , Paray Bilal Ahmad
Published: March 2022

The development of antiviral resistance has exacerbated a growing threat to public health. As a result, there is increasing demand for unconventional antivirals that can effectively replace the presently in-use drugs. Lactic acid-producing bacteria (LAB) are among the most common bacteria used in the food industry. These bacteria play an essential role in the fermentation of many foods and feed. Additionally, these bacteria are considered more economical, efficient, and safe “nutraceuticals” in the health care arsenal. Therefore, we carried out the screening and molecular characterization of raw camel milk LAB isolates and tested their inhibitory activity against influenza virus H1N1. The strain that exhibited the highest antiviral activity against the H1N1 virus, confirmed by hemagglutination assay, was identified as Lactiplantibacillus plantarum KAU007. The study also confirmed the non-cytotoxic behavior of CFCS isolated from KAU007 against MDCK cells, approving its safety concern against the mammalian cells. Besides, CFCS at 5 and 10 mg/mL significantly decreased the level of IFN-γ (p < 0.001 and p < 0.001) and IL-6 (p < 0.001 and p < 0.005) in a dose-dependent manner, respectively. This is a preliminary report about the anti-influenza activity of KAU007 isolated from camel milk. This study reinforces that camel milk contains beneficial LAB isolates with antagonistic properties against the H1N1 influenza virus.
A comunidade estética em Jacques Rancière
Authors: Nascimento Fabbrini Ricardo
Published: March 2022

O artigo mostra que Jacques Rancière situa a mudança do “regime representativo das artes” para o “regime estético” nas “Cartas sobre a educação estética do homem” de Schiller, de 1795. Sua leitura de Schiller está na origem de sua concepção de que a arte possui uma “potência comunitária”. Destaca-se, assim, que no curso dos livros Rancière apresenta modalidades de comunidade resultantes dessa potência comunitária da arte no regime estético: a comunidade dos iguais, no ensino; a comunidade consensual na arte do século XX; a comunidade na literatura (ou democracia literária); e a comunidade dissensual ou comunidade por vir [como ideia reguladora] nas artes visuais contemporâneas. Por fim, o artigo acentua que outros autores também recorreram à noção de comunidade, como Giorgio Agamben e Roland Barthes, ou, de heterotopia, como Michel Foucault, para “desenhar uma nova topografia do possível”.
THE EFFECT OF POND ASH ON THE PROPERTIES OF HEAVY CONCRETE FOR ROAD COVERING
Authors: Yavinskiy A. , Chulkova I.
Published: March 2022

Cement concrete covering is characterized by considerable durability, compared to others. But due to the high construction costs, it is not popular in Russia. To reduce costs in the construction of cement concrete pavement it is proposed to replace part of the cement, or part of the cement and sand in equal proportions simultaneously with pond ash. The paper presents the test data of heavy concrete with pond ash at different concepts of component replacement (replacement of 10% of cement; 7.5% of cement and 7.5% of sand). The effect of ash from pond ash of CHPP-4 of Omsk was studied. Omsk on the following properties of heavy concrete: strength, water absorption, density, frost resistance, abrasion. It was shown that the introduction of pond ash can have a positive effect on the strength of heavy concrete at late hardening periods (90 and 180 days). A radiographic analysis of heavy concrete with pond ash and a control ashless sample was carried out. It was found that at the introduction of pond ash into heavy concrete, pozzolanic reaction takes place, the product of which are calcium hydrosilicates. The formation of calcium hydrosilicates has a positive effect on the properties of heavy concrete. The use of pond ash as a component of heavy concrete reduces its cost and improves the environmental situation in the country.
RECONSTRUCTION WITH THE ADAPTATION OF THE OBJECT OF CULTURAL HERITAGE OF THE BUILDING OF THE OFFICE AND THE CITY ESTATE OF THE MAGISTRATE KURCHANINOV IN BELGOROD
Authors: Chechel' I. , Per'kova M. , Dubino A. , Chechel' I.
Published: March 2022

The relevance of the topic is determined by the need to solve a set of problems related to the reconstruction of cultural heritage sites of regional significance with adaptation to modern use, taking into account investment attractiveness. The problem of preserving cultural heritage in a post-industrial society is due to the preservation of the memory of a place, its history and traditions. Preservation and restoration with the adaptation of cultural heritage sites to a new function preserves the urban identity, makes the urban environment unique and attractive to residents. The town-planning and space-planning analysis of the cultural heritage object is carried out with the aim of its reconstruction and adaptation for modern use. Options for reconstruction and adaptation have been developed. Decision options are justified by a comprehensive assessment for decision making. The list of criteria and questions for quantitative assessment have been specified specifically in relation to the process of reconstruction of a cultural heritage site. As a result of quantitative analysis, an objective result is obtained. It allows evaluating the effectiveness of the developed proposals from the standpoint of the population, authorities, business and other participants in urban development. The optimal conceptual design proposal has been identified. The proposed activities will help preserve the cultural heritage site, create new jobs, and implement cultural and social projects for various consumer groups.
Shape Memory Epoxy Resin and Its Composites: From Materials to Applications
Authors: Luo Lan , Zhang Fenghua , Leng Jinsong
Published: March 2022

Shape memory polymers (SMPs) have historically attracted attention for their unique stimulation-responsive and variable stiffness and have made notable progress in aerospace, civil industry, and other fields. In particular, epoxy resin (EP) has great potential due to its excellent mechanical properties, fatigue resistance, and radiation resistance. Herein, we focus on the molecular design and network construction of shape memory epoxy resins (SMEPs) to provide opportunities for performance and functional regulation. Multifunctional and high-performance SMEPs are introduced in detail, including multiple SMEPs, two-way SMEPs, outstanding toughness, and temperature resistance. Finally, emerging applications of SMEPs and their composites in aerospace, four-dimensional printing, and self-healing are demonstrated. Based on this, we point out the challenges ahead and how SMEPs can integrate performance and versatility to meet the needs of technological development.
The Comparison Between the Early Tracheostomy and Orotracheal Intubation in COVID-19 Patients Required Mechanical Ventilation
Authors: Morshedi Mahdi , Babaei Mohammad-Javad , Bahramifar Ali , Karimi Ebrahim , Najafizadeh-Sari Shahriar , Raei Mehdi , Gholizadeh Hamed
Published: March 2022

Background: Supportive respiratory care and airway management are very important in treating COVID-19 patients with respiratory failure. There are two techniques for supporting patients with respiratory failure. Objectives: The current study aims to evaluate the efficacy and quality of patient care with early tracheostomy in intensive care unit (ICU) and compare mortality, hospital stay, and outcome between intubation and early tracheostomy. Methods: This study is conducted on total patients with confirmed COVID-19 in the ICU centers of a tertiary hospital. At the beginning of the study, all patients were intubated and connected to a mechanical ventilator. Within three days, the intensivists randomly performed bedside percutaneous dilational tracheostomy (PDT) for half of the patients. Early tracheostomy was defined as conducting tracheostomy within three days from intubation. Results: The total number of 36 patients was included in the study and categorized into two groups, including 18 patients in the early tracheostomy and 18 in orotracheal intubation. Half of the patients (50%) in the tracheostomy group were recovered from COVID-19 respiratory failure and discharged from ICU and hospital. All patients in the intubation group were expired. The length of staying alive in ICU in patients with an early tracheostomy was 26.47±3.79 compared with 7.58±2.36 days in intubated patients. Conclusion: The early tracheostomy compared with orotracheal intubation in respiratory failure patients with COVID-19 can significantly decrease mortality. However, airway management with an early tracheostomy increases the hospitalization stay and can increase recovery. So, conducting the early tracheostomy is recommended in this study.
Evaluation of Patients Presenting to the Emergency Department With Chronic Pain: An Observational Clinical Study
Authors: Sultanoğlu Tuba Erdem , Sultanoğlu Hasan
Published: March 2022

Background: Overcrowding of emergency departments (EDs), which are not suitable places to treat chronic pain and are responsible for managing acute disorders, leads to prolonged waiting times, delays in treating conditions requiring rapid intervention, patient dissatisfaction, and chaos and exhaustion in the ED. Objectives: Examine the characteristics of patients who presented to the ED with non-malignant chronic pain to determine the frequency of use and factors that caused ED use. Methods: This cross-sectional study was conducted in an ED. Three hundred ninety-two patients with chronic pain were included. Results: The mean age of the patients was 48.1±15.3 years, 62.2% were female, and 37.8% were male. Of the patients, 59.2% were married, 42.6% had elementary school education, and 56.1% were unemployed. The most common cause of ED admission was low back pain (LBP), the 32.7% used non-steroidal anti-inflammatory drugs, 16.3% used opioid analgesics, 15.8% used anticonvulsants, 13.2% used anticonvulsants antidepressant drugs, 22% did not use any medication. The reasons for presenting to the ED for chronic pain were 13.3% for medication prescription, 74.5% for receiving analgesics, and 12.2% for a diagnosis. The mean Patient Health Questionnaire-9 (PHQ-9) scale score of the participants was 12.82±3.98, which indicated moderate depressive symptoms. The mean Generalized Anxiety Disorder-7 scale score was 9.84±3.23, which indicated mild generalized anxiety disorder. Conclusion: Instead of trying to suppress pain, emphasis should be put on preventing overcrowding in EDs, which are intended to manage acute conditions rather than chronic pain, informing patients about the methods of coping with pain, increasing their quality of life, and integrating them into social life.
EFFICIENCY IMPROVING FOR URLLC IN ADVANCED COMMUNICATION NETWORKS
Authors: КАШКАРОВ Д.В. , ПАРАМОНОВ А.И. , КУЧЕРЯВЫЙ А.Е.
Published: March 2022

Предложен метод повышения эффективности использования ресурсов сети при предоставлении услуг с высокими требованиями uRLLC (ultra Reliable Low Latency Communications) к задержке путем организации многосвязных соединений. Метод основан на решении задачи оптимального выбора маршрутов из числа доступных с помощью динамического программирования. Показана возможность решения как задачи выбора заданного количества маршрутов, так и количества, обеспечивающего требуемую величину задержки. Близкое к оптимальному решение позволяет повысить эффективность использования ресурсов сети.

The paper proposes a method for increasing the efficiency of using network resources when providing services with high uRLLC (ultra Reliable Low Latency Communications) requirements for delay by organizing multi-link connections. The method is based on solving the problem of optimal selection of available routes using dynamic programming. The proposed method allows solving both the problem of selecting a given number of routes and minimizing the number of routes providing the required delay. A near-optimal solution improves the efficiency of network resource utilization.
INVESTIGATION OF THE INFLUENCE OF NETWORK CHARACTERISTICS ON THE FUNCTIONING OF A MULTIFUNCTIONAL ROBOTIC ARM
Authors: ГОРБАЧЕВА Л.С. , ФАМ В.Д. , МАТЮХИН А.Ю. , КУЧЕРЯВЫЙ А.Е.
Published: March 2022

Приведены результаты экспериментальных исследований по предоставлению услуг телеприсутствия на модельной сети. Исследования проводились с помощью многофункционального робота-манипулятора Dobot Magician при предоставлении через модельную сеть услуг по перемещению грузов и рисованию окружностей. Проведено имитирование различных условий по затуханию, задержкам, расстояниям, на которых оказывались услуги, и битовым ошибкам. Сделаны выводы о единообразии требований к сетевым параметрам при оказании разных услуг одним и тем же многофункциональным роботом-манипулятором и о целесообразности уточнения рекомендаций МСЭ-Тв части величины задержки на 1 км.

The paper discusses the results of the experimental investigation on the provision of telepresence services on a model network. The investigation was carried out using the Dobot Magician multifunctional robotic arm, which provided services for moving loads and drawing circles through a model network. Various conditions for attenuation, delays, distances at which services were provided, and bit errors were simulated. Conclusions were drawn about the uniformity of requirements for network parameters when providing various services by the same multifunctional robotic arm and about the advisability of clarifying the ITU-T recommendations in terms of the delay per kilometer.
Mental Health in Conditions of COVID-19
Authors: Протько Н.Н. , Патеюк И.В.
Published: March 2022

В статье описаны особенности психического здоровья людей в ситуации пандемии COVID-19: основные психотравмирующие факторы пандемии, типы психологических реакций на ситуацию, спектр психических расстройств, в том числе у пациентов с коронавирусной пневмонией. Приведены рекомендации по охране психического здоровья для населения в условиях пандемии COVID-19.

In the article, there are described the features of mental health of people in the situation of COVID-19 pandemic: the main psychotraumatic factors of the pandemic, the types of psychological reactions to the situation, the spectrum of mental disorders, including patients with coronavirus pneumonia. The recommendations on mental health protection in the context of COVID-19 pandemic are given.
A Clinical Case of Basal Cell Carcinoma Formation at the Site of Intralesional Injection of Triamcinolone Acetonide
Authors: Волькенштейн П. , Заславский Д.В. , Соболев А.В. , Скрек С.В. , Васильев Н.Ю. , Юновидова А.А. , Заславская О.Л. , Машука Д.М. , Зелянина М.И. , Рылева У.М.
Published: March 2022

В статье представлен клинический случай развившейся базальноклеточной карциномы в месте введения триамцинолона. Особенностью клинического наблюдения является роль глюкокортикостероида как триггерного фактора в развитии злокачественной пролиферации кожи.Описан механизм действия триамцинолона ацетонида на ткани, а также основные группы лекарственных веществ, обладающие потенциальным риском иммуносупрессии и, как следствие, развития злокачественных опухолей кожи.Данный клинический случай интересен с точки зрения эпидемиологии для выявления группы риска развития базальноклеточной базалиомы у пациентов с длительным инъекционным применением кортикостероидов.

The article presents a clinical case of basal cell carcinoma developed at the site of triamcinolone injection. A feature of this case report is a role of glucocorticosteroids as a trigger factor in the development of malignant skin proliferation.The triamcinolone acetonide’s mechanism of action on tissues is described, as well as the main groups of drugs that have a potential risk of immunosuppression and as a consequence of the development of malignant skin tumors.This clinical case is interesting from the point of view of epidemiology for identifying the risk group for the development of basal cell basal cell carcinoma among patients with prolonged injection of corticosteroids.
Anemic Syndrome in Gastroenterological Diseases: Problems and Solutions
Authors: Рыбина О.В. , Губкин А.В. , Сахин В.Т. , Рукавицын О.А.
Published: March 2022

Анемический синдром – наиболее частое внекишечное осложнение у пациентов с патологией желудочно-кишечного тракта (ЖКТ), которое может значимо ухудшить качество жизни. В зависимости от сочетания патогенетических механизмов выделяют железодефицитную, анемию хронических заболеваний, В12-дефицитную и фолиеводефицитную анемию. Другие варианты анемии встречаются реже. Необходимо проведение комплексного лабораторного обследования для установления ведущего фактора в развитии анемии и подбора адекватной терапии. Парентеральные формы препаратов железа и витаминов более предпочтительны для данной категории пациентов из-за более высокой биодоступности, низкого профиля безопасности и минимального негативного влияния на ЖКТ. Препараты эритропоэтина и ингибиторы провоспалительных цитокинов применяются в основном для коррекции анемии хронических заболеваний. Последние хорошо себя показали при терапии пациентов с анемическим синдромом на фоне тяжело протекающих воспалительных заболеваний кишечника. Проводятся различные клинические исследования, направленные на внедрение новых препаратов, корректирующих анемию. Однако к настоящему времени опыт их применения практически отсутствует.В этом обзоре мы постарались объединить и систематизировать накопленную информацию о проблеме анемического синдрома при патологиях желудочно-кишечного тракта.

Anemic syndrome is the most frequent extraintestinal complication in patients with gastrointestinal tract pathology, which can significantly impair the quality of life. Depending on the combination of pathogenetic mechanisms, the iron deficiency, anemia of chronic diseases, B12-deficiency, and folate deficiency anemia are distinguished. Other types of anemia are less common. It is necessary to conduct a comprehensive laboratory examination to reveal the leading factor in the development of anemia and select adequate therapy. Parenteral forms of iron and vitamin preparations are more preferable for this category of patients due to their higher bioavailability, low safety profile, and minimal negative effect on the gastrointestinal tract. Erythropoietin preparations and inhibitors of proinflammatory cytokines are used mainly for the correction of anemia of chronic diseases. The latter showed themselves well in the treatment of patients with anemic syndrome on the background of severe inflammatory bowel diseases. Various clinical trials are being conducted to introduce new drugs to correct anemia. However, today, there is practically no experience of their application.In this review, we tried to combine and systematize the accumulated information on the problem of anemic syndrome in the pathologies of the gastrointestinal tract.
Evaluation of the Safety of Direct-Acting Antiviral Agentsin Patients with Chronic HCV-Infection and with UGT1A1*28 Polymorphism
Authors: Лукашик С.П. , Карпов И.А. , Синявская М.В. , Даниленко Н.Г. , Анисько Л.А. , Давыденко О.Г. , Красько О.В.
Published: March 2022

Цель. Оценить безопасность лекарственных средств прямого противовирусного действия (ЛС ППД) у пациентов с хронической инфекцией, вызванной вирусом гепатита С (ВГС-инфекцией), и полиморфизмом UGT1A1*28.Материалы и методы. Проведено клиническое открытое нерандомизированное ретроспективное обсервационное когортное исследование безопасности ЛС ППД у пациентов (n=143) с хроническим гепатитом С (ХГС) и циррозом печени (ВГС-ЦП) и полиморфизмом UGT1A1*28. Результаты. Билирубин повышался до 1-й степени у 52,9% при ХГС и у 47,1% при ВГС-ЦП, до 2-й или 3-й степени – у 55,6% при ХГС и 44,4% – при ВГС-ЦП (р=0,655). У пациентов с (ТА)6/(ТА)6 повышение показателя до 1-й степени наблюдалось у 23,5%, с (ТА)6/(ТА)7 – у 39,2%, с (ТА)7/ (ТА)7 – у 37,3%. Повышение билирубина до 2-й или 3-й степени чаще отмечалось при (ТА)6/ (ТА)7 и (ТА)7/(ТА)7 генотипах (50% и 44,4% соответственно) по сравнению с (ТА)6/(ТА)6 (5,6%) (p<0,001). Непосредственный вирусологический ответ достигнут в 88,6% при отсутствии повышения билирубина, в 91,8% – при повышении билирубина до 1-й степени и в 100% – до 2-й или 3-й степени (р=0,446). Отсутствовало повышение АЛТ у 98,6%, АСТ – у 99,3% и щелочной фосфатазы – у 80%. Ни у кого из пациентов лечение не было отменено.Выводы. Лечение пациентов с хронической ВГС-инфекцией ЛС ППД является безопасным.

Objective. To determine the safety of DAA in patients with chronic HCV-infection and UGT1A1*28 polymorphism.Materials and methods. A clinical open non-randomized retrospective observational cohort study was conducted to assess the safety of DAA in patients (n=143) with chronic hepatitis C (CHC) and liver cirrhosis (HCV-CP) and UGT1A1*28 polymorphism.Results. Bilirubin increased to 1 degree in 52.9% with CHC and in 47.1% with HCV-CL, to 2 or 3 degrees in 55.6% with CHC and 44.4% with HCV-CL (p=0.655). Bilirubin increased to 1 degree in patients with (TA)6/(TA)6 in 23.5%, with (TA)6/(TA)7 – in 39.2%, with (TA)7/(TA)7 – in 37.3%. Bilirubin increased to 2 or 3 degrees with (TA)6/(TA)7 in 50%, with (TA)7/(TA)7 genotypes in 44.4% and with (TA)6/(TA)6 – in 5.6% (p<0.001). IVR was achieved in 88.6% patients without an increase in bilirubin, in 91.8% with an increase to 1 degree and in 100% to 2 or 3 degrees (p=0.446). There was no increase in ALT in 98.6% cases, AST in 99.3% patients, and alkaline phosphatase in 80% ones. None of the patients had their treatment canceled.Conclusions. The treatment of patients with chronic HCV-infection with DAA is safe.
Mesas Temáticas - 25º Seminário de Pesquisa e 20º Seminário de Iniciação Científica
Authors: Organizadora Comissão
Published: March 2022

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El “informe del inquisidor Avellaneda” sobre las complicidades brujeriles en los valles centrales y orientales del Pirineo navarro
Authors: Moya Mangas Jesús , Floristán Imízcoz José Manuel
Published: March 2022

Nueva edición del «Informe de Avellaneda» sobre la brujería en los valles pirenaicos navarros. Se ofrece una edición sinóptica de cuatro versiones (A-D), dos editadas por Caro en 1933 y dos nuevas encontradas en el Archivo Histórico Nacional y en la Academia de las Ciencias Morales y Políticas. Tras un escueto panorama de la brujomanía en Navarra en el siglo XVI, se estudia el contenido del informe, se hace una serie de consideraciones sobre el autor del texto base y se formula la hipótesis de su posterior reelaboración por fray Antonio de Guevara en el marco de las discusiones de la Junta de Granada (1526) sobre el fenómeno brujeril.
Tres curas carlistas navarros espías del Intelligence Service
Authors: Alli Aranguren Juan Cruz
Published: March 2022

Durante la Segunda Guerra Mundial España fue un nido de espías. El Intelligence Service creo redes para preparar una invasión en caso de que lo hiciera Alemania para tomar Gibraltar. Una de ellas se estableció en Navarra, captando a tres sacerdotes carlistas para que organizaran unidades militares que apoyasen la invasión inglesa. Se ha situado en el contexto nacional y del carlismo, con documentos de archivo y bibliografía sobre el mundo carlista. Utilizaron la restauración monárquica para lograr adhesiones, ocultando su vinculación militar y financiera con Inglaterra.
Economía creativa, economía popular y economía solidaria
Authors:   , Arboleda López Liliana
Published: March 2022

Estudio sobre la economía creativa en Colombia y Medellín, sector que incluye las actividades económicas vinculadas a las artes, la cultura, la educación, el patrimonio, la moda, las industrias audiovisuales, fonográficas, los contenidos digitales, el diseño, ciertos segmentos del software y del turismo: incluyendo las políticas llevadas a cabo y la situación los colectivos, sus vínculos con la economía social y solidaria (ESS), así como con la economía popular y social (EPyS) como será definida en la tesis -colectivos pequeños que, sin patrón sostienen proyectos con grandes problemas de capital y de escala, que difícilmente logren un excedente y tienen una subjetividad particular y tipos específicos de relación entre los miembros Se abordan específicamente los colectivos de la economía creativa de Medellín, estudiando la normativa y la evolución de la actividad desde finales de los años 90s a la fecha y luego se profundiza en el colectivo de La Pascasia.
Estudio cinético de reacciones fotoquímicas y térmicas en las que intervienen átomos de flúor y radicales FCO
Authors:   , Croce Adela Ester
Published: March 2022

De las investigaciones sistemáticas realizadas por el Prof. Schumacher y colaboradores, sobre la cinética de las reacciones del flúor y del monóxido de flúor, se conoce el mecanismo de la descomposición térmica y fotoquímica de este último, así como el comportamiento cinético en reacciones fotoquímicas y térmicas de ambos reactivos con gran número de compuestos. En particular, se ha estudiado la reacción térmica entre F2O y CO, la reacción fotoquímica a 366 nm entre los mismos reactivos y la reacción térmica entre F2, CO y O2. En los mecanismos de estas reacciones se postula la intervención de los radicales OF, FCO, FOCO, FCO, 02 y átomos de F.
The Influence Of Online Board Game (Rhetoric) Towards Students' Speaking Skill
Authors: Nurpalah Gina , Nugraha Muhammad Anjar , Dewi Lusiana Suciati
Published: March 2022

Research conducted in SMAN 1 Ciasem. This research used a quantitative and qualitative method. The data was served numerically and tested by non-parametric statistic Mann-Whitney. The design of the study was quasi-experimental. An oral test was used as the research instrument to get the data, consisting of pre-test and post-test questionnaires and observation to know the students’ attitude in Speaking Skills. Based on the explanation above the purpose of this research is to find out the influence of Online board Game (Rhetoric) towards Students’ Speaking skill. The result of the research in experiment class and control class in post-test data the significance Asymp. Sig (2-tailed) in the pre-test is 0.127, and the score is more than the significant (?) = 0.05. and the Asymp. Sig (2-tailed) in post-test is 0.319 it shows that the value is more than the significant hypothesis criteria 0.05 the result is H0 is accepted. It shows that the Correlation (R) value is 0.193a and R Square is 0.37, and the significant value from the Anovaa 402b >0.05 the result H0 Accepted. It concluded that the correlation between online board games on speaking skills affects the amount of 3,7% and other variables influence 96,3%. It means that there is no significant influence of Online Board Game (Rhetoric) towards students’ speaking skills in the other words tells that the variable X (questionnaire) then declines variable Y (post-test). However, although there is no achievement in a significant value, the results showed that the use of Online Board Game (Rhetoric) positively affected student engagement and motivation. The way the teacher manages two classes has similarities in behavior, attitude, and values. But there are deficiencies in delivering material and direct communication with students because of online learning and can affect students’ actively responding when learning begins.
Interdepartmental Cooperation of the Rospotrebnadzor Office in the Republic of Tatarstan in Carrying out the Order to Provide Free Hot School Meals to Pupils in Grades 1-4
Authors: Patyashina MA , Avdonina LG , Fomicheva GB , Karpova MV , Gimadieva LR
Published: March 2022

Introduction: Proper, healthy and safe school nutrition is an important factor in maintaining health and physical growth of a child from a medical point of view, which, in the long run, determines health of the future generations. High-quality food raw materials, a modern material and technical base, qualified personnel, and promotion of healthy eating among schoolchildren and their parents are crucial for successful school feeding. Objective: To analyze the experience and effectiveness of cooperation between the Office of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing (Rospotrebnadzor) in the Republic of Tatarstan, executive authorities and parents to improve school nutrition in the 2020/21 academic year. Materials and methods: The analytical method was used to assess the effectiveness of interdepartmental interaction when carrying out the order to ensure provision of free hot school meals to pupils in grades 1–4 (aged 7–11 years) in the Republic of Tatarstan. Results: Well-coordinated effective actions were implemented in the republic in 2020–2021 to organize free hot meals for elementary school children. They consisted of planned improvement of school catering units, elaboration and introduction of unified menus, including those for children with special dietary needs. Regular inspections of school catering helped improve its quality and enhance responsibility of officials in charge. The experience gained can be applied in other constituent entities of the Russian Federation. Conclusion: Thanks to the close cooperation of executive authorities of the Republic of Tatarstan, the Rospotrebnadzor Office in the Republic of Tatarstan, and the parental community, effective work has been carried out to organize provision of free hot school meals to first to fourth graders since September 1, 2020. All the improvements shall contribute to prevention of diet-related diseases in schoolchildren.
Anatomical features of the human fetus mandible
Authors: Neprokina Anastasiya V. , Lutsay Elena D. , Vinidictova Marina A.
Published: March 2022

Aim to obtain new data on the anatomy of the mandible of a human fetus aged 1923 weeks.
Material and methods. The object of the study was 40 mandibles of human fetuses of both sexes aged from 19 to 23 weeks. The morphological method (macromicroscopic preparation; the method of saw cuts according to N.I. Pirogov; production of serial histotopograms) and the method of ultrasound scanning by the device VOLUSONS 10, RAB 6 RS sensor in 2D mode and in the "Skeleton" program (3D mode) were used.
Results. In fetuses aged 1923 weeks the mandible represents a paired bone connected in the center by a symphysis. According to the shape of the body, it is possible to select wide and short, long and narrow mandibles in a ratio of 2 to 1, respectively 67% and 33%. The length of the alveolar arch is 52.4 5.6 mm (with a range of 45.360.2 mm), the angular width is 23.4 1.7 mm (with a range of 19.027.8 mm). The height of the branch at the cutting level was equal to 6.2 1.4 mm (with a range of 3.69.0 mm). On the anterior surface of the body, one chin opening is determined on both sides, at an average distance of 16.4 mm from the angle of the mandible and at a height of 2.2 mm. On the inner surface of the branch, the opening of the mandible is determined, located at a distance of 3.6 1.1 mm from the angle, 3.2 0.9 mm from the anterior edge of the branch, 4.1 1.2 mm from the posterior edge of the branch. In the second trimester of pregnancy, dental alveoli are determined in the mandibular dental arch of the fetus. Significant sex differences were found for the angle of the mandible (p 0.05). In girls, the angle was 141.1 10.1, in boys 129.5 9.4.
Conclusion. The mandible of the fetus at the age of 1923 weeks is formed and has fetal characteristics. During this period, no significant bilateral differences were revealed, sexual differences start to form.
Evolution of accounting and information systems in cashless payments
Authors: Nazarova Iryna
Published: March 2022

Introduction. Digitalization of the market economy creates conditions for minimizing cash payments. The abandonment from cash payments is justified by positive trends in: distancing e-commerce, the use of cashless payment systems and pandemic changes in socio-economic processes. Changes in the cash payments methods require the introduction of accounting and information systems for electronic recording of money operations, accounting and reporting of payment transactions, guarantees for the safety and control of cashless money.Purpose. The aim of the article is to research the evolution of accounting and information systems in the implementation of cashless payments in international and domestic markets for payment services, theoretical justification of the definition of «cashless payments» and develop proposals for their streamlining.Method. Methods of scientific research are: systematic approach to the study of economic processes, elements of the theory of scientific knowledge, dialectical method to determine the essence of cashless payments; historical - to research the evolution of cashless payments; analytical - to assess modern information systems for the organization and accounting of cashless payments.Results. The research of the cashless payments evolution shown the permanence changes in the methods of conducting money transactions. The accounting and information system of enterprises and corporations must timely respond on innovative transformations. The article improves and regulates the elements of the conceptual apparatus for cashless payments using bank payment cards, electronic money and other modern payment methods for the developing of their registration and reflection in accounting and reporting. Perspectives. Technological progress and the COVID-19 pandemic have become the driving force of society’s transition to expanding the cashless payment regime. Technologies for remote banking and non-banking payment systems are permanently improving. Accounting and information systems for providing complete and objective information to business and society should be in line with this progress.
Comparison of the options of systems for adjusting the salt composition of water from underground sources
Authors: Касаточкин А.С. , Ларионов С.Ю. , Пантелеев А.А. , Рябчиков Б.Е. , Шаповалов Д.А. , Харитонов Н.А. , Шилов М.М.
Published: March 2022

Для питьевого водоснабжения часто используются подземные источники воды с повышенным содержанием солей жесткости. Для достижения питьевого качества воды требуется снижение ее жесткости. Известные методы умягчения приводят к образованию значительного количества жидких и твердых отходов – минерализованных сточных вод или шламов, не подлежащих утилизации. Реагентное умягчение воды в осветлителях используется достаточно редко из-за трудности приготовления реагентов, поддержания необходимой и постоянной температуры воды, сложности установок и их обслуживания. В 1990-х годах разработана технология реагентного умягчения в интенсифицированных реакторах (вихревых и во взвешенном слое), получившая довольно широкое применение в питьевом водоснабжении. Такие аппараты достаточно активно используются в Европе и США. В настоящее время АО «Научно-производственная компания «Медиана-Фильтр» проводит работы по созданию и исследованию реакторов данного типа. Они имеют высокую удельную производительность – 50–100 м3/(м2‧ч), и их обслуживание существенно проще по сравнению с осветлителями. Производительность таких установок достигает тысяч кубометров в час. Главное их преимущество заключается в отсутствии жидких сбросов и получении отхода в твердом виде, который может быть утилизирован, при этом выход чистой воды практически составляет 100%.

Underground water sources with a high content of hardness salts are often used for drinking water supply. To achieve drinking water quality reducing its hardness is required. Known methods of softening result in the formation of a significant amount of liquid and solid wastes, i. e. mineralized wastewater or sludge that cannot be disposed of. Chemical water softening in clarifiers is used quite rarely owing to the difficulty of preparing chemicals, maintaining the constant required water temperature, and the complexity and maintenance of the equipment. In the 1990s, the technology of chemical softening in intensified reactors (vortex and blanket) was developed that gained widespread use in drinking water supply. Such units are quite frequently used in Europe and USA. At present Mediana-Filter Research and Production Company JSC is taking on the task of designing and testing reactors of this type. They have a high specific output of 50–100 m3/(m2‧h), and their maintenance is much easier compared to clarifiers. The capacity of such plants reaches thousands of cubic meters per hour. Their main advantage is the elimination of liquid discharges and generation of solid wastes that can subject to utilization, while the yield of clean water is about 100%.