bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect of Catheter-Related Infection Control Education on Surgical Nurses' Knowledge Levels and Attitudes: A Randomized Controlled Trial
Authors: Akdemir Habibe Filiz , Gezginci Elif
Published: June 2024

Background

Catheters are commonly used in health care. As nurses play an active role in the prevention of catheter-related infections, their knowledge and attitudes on this subject are important. The goal of this study was to determine the effect of an educational intervention about catheter-related infection control precautions on nurses' knowledge levels and attitudes.

Method

This study was a single-center randomized controlled trial. The intervention group (
n
= 35) received evidence-based face-to-face education. The control group (
n
= 35) received routine in-service training. The nurses' knowledge and attitudes were assessed before, immediately after, and 3 months after the education.

Results

After the training, the intervention group had statistically higher total scores than the control group on both scales immediately after the training (
p
< .001 and
p
= .008, respectively) and 3 months after the training (
p
= .001 and
p
< .001, respectively).

Conclusion

The evidence-based structured educational intervention about catheter-related infection prevention practices positively affected the knowledge and attitudes of surgical nurses.

[
J Contin Educ Nurs.
2024;55(10):479–486.]
A Practical Approach to Integrating a Telehealth Course and Health Informatics Skills Into a Curriculum for Advanced-Level Nursing Students
Authors: Hebert Sharisse , Tietze Mari , Gaines Chloe
Published: June 2024

Background:

Telemedicine and health informatics are a common aspect of patient care delivery in the United States. Graduate-level nursing students must be knowledgeable of telehealth and health informatics prior to entering the workforce as an advanced practice nurse. Nursing educators must provide educational opportunities within the curriculum that focus on telehealth and health informatics concepts that align with competencies.
The Essentials: Core Competencies for Professional Nursing Education
includes a new Domain #8 called, “Informatics and Healthcare Technologies,” where five key subdomains of this competency are defined.

Method:

This article describes the college's approach to incorporating telehealth and health informatics into the graduate-level curriculum and the associated alignment to the
2022 Essentials
.

Results:

Faculty professional development and course revision strategies improved the infrastructure for teaching telehealth and health informatics.

Conclusion:

The new Domain, #8, Informatics and Healthcare Technologies, can be successfully infused into the DNP curriculum with student engagement.

[
J Nurs Educ
. 2024;63(X):XXX–XXX.]
Emerging Oral Pharmaceuticals for Dry Age-Related Macular Degeneration: Mechanism of Action, Current Clinical Status, and Future Directions
Authors: DeBoer Charles M.T. , Rasmussen Ditte K. , Franco Joel A. , Mahajan Vinit B.
Published: June 2024

Dry age-related macular degeneration (AMD) has been historically managed with lifestyle modifications, monitoring for conversion to wet AMD, and vitamins. Recently there has been a flurry of research focused on discovering new targets to prevent worsening of dry AMD. In 2023, the US Food and Drug Administration approved the first two intravitreal complement inhibitors to slow the rate of geographic atrophy progression. However, serial intravitreal injections for a chronic progressive disease are burdensome for patients and have procedural risks. Therefore, there is significant research to discover novel oral medications to manage dry AMD. Several oral medications are currently in phase 2 and 3 clinical trials for dry AMD, whereas others have had recent readouts on their clinical trials and efficacy. The purpose of this review is to describe the therapeutic pathways currently being investigated and to provide an update on the clinical status of novel oral medications for the management of dry AMD.

[
Ophthalmic Surg Lasers Imaging Retina
2024;55:528–534.]
Multi-modal adaptive feature extraction for early-stage weak fault diagnosis in bearings
Authors: Xu Zhenzhong , Chen Xu , Yang Linchao , Xu Jiangtao , Zhou Shenghan
Published: June 2024

We present a novel multi-modal adaptive feature extraction algorithm considering both time-domain and frequency-domain modalities (AFETF), coupled with a Bidirectional Long Short-Term Memory (Bi-LSTM) network based on the Grey Wolf Optimizer (GWO) for early-stage weak fault diagnosis in bearings. Singular Value Decomposition (SVD) was employed for noise reduction, while Complete Ensemble Empirical Mode Decomposition with Adaptive Noise (CEEMDAN) was utilized for signal decomposition, facilitating further signal processing. AFETF algorithm proposed in this paper was employed to extract weak fault features. The adaptive diagnostic process was further enhanced using Bi-LSTM network optimized with GWO, ensuring objectivity in the hyperparameter optimization. The proposed method was validated for datasets containing weak faults with a 0.2 mm crack and strong faults with a 0.4 mm crack, demonstrating its effectiveness in early-stage fault detection.
Novel categorical relations between $ \mathcal{L} $-fuzzy co-topologies and $ \mathcal{L} $-fuzzy ideals
Authors: Ramadan Ahmed , Fawakhreh Anwar , Elkordy Enas
Published: June 2024

The goal of this paper is to construct novel relationships among $ \mathcal{L} $-fuzzy ideal, $ \mathcal{L} $-fuzzy co-topological, and $ \mathcal{L} $-fuzzy pre-proximity spaces in complete residuated lattices. We illustrate and prove four functors between the categories of those spaces and finally, we give examples.
Moving the needle forward in health disparities: An education initiative
Authors: Reddy Swapna B , Speer Matthew J , Todsen Jessica , Mutyala Subhakar , Samadder Niloy Jewel L , Moreno Giovanna GG , Lewis Yerronda L , Omar Farhia M , Mishra Shambhavi , Umar Sarah B
Published: June 2024

ObjectiveThis paper sought to evaluate the impact of a year-long Health Equity Curriculum (HEC) on the knowledge of health disparities, cross-cultural humility, and empathy among physicians, trainees, and research staff.

BackgroundThere has been an increase in the inclusion of equity, cultural humility, and the social determinants of health into medical education at various levels. However, the frequency of this education is low and not well quantified or defined. The authors report the results of an education program, namely the HEC, on the knowledge of health disparities, cross-cultural humility, and empathy.

Materials and methodsThe HEC was delivered between March 2020 and May 2021. It included the following four modules: the social determinants of health, cultural humility, health literacy, and unconscious bias. The participants attended lectures and reviewed articles/videos using online modules and reflection assignments. The Jefferson Scale of Empathy (JSE) and the Cross-Cultural Competence Instrument for Health Care Professionals (CCCHP) were administered pre- and post-HEC. The results were statistically analyzed.

ResultsOf the 102 enrolled participants, 46 completed the entire course. The JSE showed a statistically significant improvement in the empathy scores from pre-HEC to post-HEC (p < 0.01). The CCCHP showed a significant improvement from pre-HEC to post-HEC total scores and in subcomponent scores of Motivation/Curiosity, Attitude, and Knowledge (p < 0.05). There were no significant differences in scores for the Skills and Emotions/Empathy subcomponents.

ConclusionsEnrollment and completion in the HEC were associated with statistically significant improvements in the validated measures of cultural competence and empathy. Scaling this type of content and curriculum can educate professionals on equity and serving diverse communities. A further study is warranted.
A província do Maranhão no processo de Independência: estratégias e perspectivas dos homens de negócio “portugueses”
Authors: Cutrim Luisa Moraes S.
Published: June 2024

Os primeiros anos do século XIX foram marcados pelo fortalecimento dos homens de grosso trato no Maranhão. Contudo, a capitania passou por momentos conturbados entre a adesão a Revolução do Porto, em 1821, e a “adesão” à Independência do Brasil, em 1823. A forte oposição dos negociantes portugueses ao projeto de separação política de Portugal prejudicou o poderio alcançado por estas figuras relacionadas ao comércio após a “adesão” da província. Os homens de negócio da praça comercial do Maranhão passam a serem entendidos, pós-Independência, como “portugueses” e, consequentemente, uma ameaça à construção do novo Estado. Em 1825, após a diminuição dos embates, tais negociantes buscaram se restabelecer ao lado do novo governo provincial. Sendo assim, o objetivo do presente artigo é analisar a atuação dos homens de negócio portugueses no processo de resistência e de “adesão” do Maranhão ao projeto de separação política iniciado no Rio de Janeiro, entre 1821 a 1826. Por meio da atuação do Corpo de Comércio, busca-se analisar as estratégias utilizadas pelos negociantes “portugueses” para se reposicionar politicamente no Maranhão, assim como, discutir as diferentes nuances que marcaram a construção do recém-criado Estado do Brasil.
Bhim Geet and the Ambedkarite Movement: The Genesis of a Cultural Field of Protest
Authors: Cabalion Joël , Jugand Julien
Published: June 2024

This paper sketches the history of a cultural and artistic music category called Bhim Geet (or Bheem Geet), songs to Bhimrao Ambedkar, principal redactor of the Indian Constitution and political hero of the Dalits. By examining this aesthetic construct and its social milieu, we trace back and uncover through the lens of music and artistic performances some of the tensions and stakes the Dalits were up against in Maharashtra from a cultural point of view. What does it entail to sing caste struggles in contemporary India? What does emancipation mean for Dalits, both culturally and aesthetically? Ambedkar’s caste conversion to Buddhism in Nagpur in 1956 is now a relatively well-known episode of India’s postcolonial history. It is less known how the ex-Mahar caste, alternately called Buddhists, neo-Buddhists or Ambedkarites, have reconstructed themselves from an inseparably aesthetic and social point of view. We intend to address this lack and show how circulating cultural practices have enabled the construction of a subaltern kind of nationalism. These practices have also made possible legalist dissent through musical narratives widely influenced by Muslim poetry and musical forms, such as Qawwali, although Hindu devotional styles more commonly found in bhajan and kirtan, which are widespread musical genres in India and beyond, have also had an impact. A small fieldwork video accompanies this article and begins by proposing a few sonic examples to its readers to illustrate this significant variation and pool of influences within the category of Bhim Geet.
N’enseigne pas chez nous qui veut ! Les motifs de l’engagement des enseignants en microlycée
Authors: Zaffran Joël
Published: June 2024

Le microlycée est un dispositif expérimental de retour volontaire aux études des jeunes en situation de décrochage scolaire. Sa mission est de les mener jusqu’aux épreuves du baccalauréat. Pour cela, des enseignants sont disposés à accompagner ces jeunes, quitte à sortir de leur rôle professionnel. L’article s’intéresse à ces enseignants qui s’engagent dans un microlycée malgré les infléchissements statutaires pour tenir la relation avec les jeunes. Quels sont les motifs de leur engagement ? Pour répondre, l’article procède en trois temps. Dans un premier temps, il présente le dispositif. Dans un deuxième temps, il repère dans les entretiens avec les enseignants les raisons du désir de « faire l’école autrement » qui préexiste à l’entrée au microlycée. Dans un troisième temps, il s’attarde sur le fonctionnement du microlycée de manière à montrer que les relations entre les pairs sont une condition de l’engagement au même titre que les relations avec les jeunes. En conclusion, l’article montre que si le microlycée est indispensable aux jeunes, il est utile aussi aux enseignants.
Débattre des transitions pour reconcevoir les formations
Authors: Joly Nathalie , Berriet-Solliec Marielle
Published: June 2024

Cet article fait le bilan d’actions menées entre 2022 et 2023 dans un établissement d’enseignement supérieur en vue de mobiliser enseignants et étudiants autour d’une réflexion d’ensemble sur les façons d’adapter les formations aux défis de l’anthropocène. Les deux auteures analysent leur portage d’initiatives à la lueur des concepts de la sociologie des mobilisations et des recherches sur la participation du public en démocratie. En s’appuyant plus spécialement sur les travaux consacrés à l’institutionnalisation de la participation, elles distinguent parmi les initiatives impulsées celles qui relèvent d’une « participation conventionnelle » (création d’un groupe de travail Transitions, large sondage auprès des élèves-ingénieurs) et celles liées à une « participation non conventionnelle » (tribune publiée dans un média national et soumise à signature), ce choix étant destiné à impliquer un nombre plus étendu d’acteurs et à élargir l’échelle du débat, du local au national. In fine, la faiblesse des ressources et la quasi-absence de réseaux de sociabilité préexistants entre les différents protagonistes conduisent à un échec de la mobilisation nationale, tandis qu’un processus de transformation des contenus et des situations d’enseignement s’enclenche à petits pas, en l’absence de modes de gouvernance clairement établis pour leur accompagnement.
Enseigner le territoire : un enjeu appréhendé à partir d’une analyse renouvelée de la transposition didactique
Authors: Del Corso Jean-Pierre , Asloum Nina , Gillet Guillaume
Published: June 2024

Au cours des dernières années les rénovations de programmes se succèdent dans le système de la formation agricole. De nouveaux objets d’enseignement émergent dans les curricula sans être toujours adossées à des savoirs clairement identifiés. Cette situation a pour conséquence de plonger les enseignants dans des états d’incertitude plus ou moins profonds. Partant de ce constat, l’article réinterroge la portée du modèle de Transposition Didactique initialement pensé par Yves Chevallard et Marie-Alberte Johsua. Ayant montré les spécificités du processus de transposition didactique à l’œuvre dans l’enseignement agricole, il examine l’intérêt de recourir à des dispositifs innovants de co-production de ressources pédagogiques conçus à l’articulation entre recherche et formation. Il débouche alors sur un modèle de TD enrichi. L’introduction récente de la thématique du territoire dans le référentiel de formation du module S2 « Territoires et sociétés » du baccalauréat Sciences et technologies de l’agronomie et du vivant (STAV) sert de cas d’étude.
Ludwig Harigs Sprechstundenroman, Wittgensteins Gebrauchstheorie und die Nachkriegsavantgarden: ein Fallbeispiel
Authors: Angerer Simon
Published: June 2024

Der Artikel behandelt Ludwig Harigs ‚Roman‘ Sprechstunden für die deutsch-französische Verständigung und die Mitglieder des gemeinsamen Marktes, ein Familienroman im Rahmen einer Bezugnahme auf Wittgenstein, die sich implizit und explizit in vielen Texten der deutschsprachigen Nachkriegsavantgarden findet. Fokussiert werden soll hierbei die literarische Appropriation von Wittgensteins Gebrauchstheorie und seines Konzepts des Sprachspiels, die auf der Form- und Verfahrensebene des Textes nachvollzogen werden soll. Zugleich wird ein Seitenblick auf die Wittgenstein-Rezeption der Wiener Gruppe und die daraus hervorgehende Wittgenstein-Kritik Oswald Wieners geworfen und mit Harigs Position in Beziehung gesetzt, wodurch sehr unterschiedliche – aber immer von Wittgenstein ausgehende – Wege neoavantgardistischer Sprachreflexion und Sprachkritik unter die Lupe genommen werden.
A rare case of fatal Emamectin poisoning
Authors: Vikram S. , Sathish K.
Published: June 2024

Emamectin is a macrocyclic lactone-ring insecticide widely used on various vegetable crops and fruits. Emamectin acts through high-affinity gamma-aminobutyric acid (GABA) receptors by increasing the chloride permeability, thus causing muscle paralysis in invertebrates. Here we report a fatal case of intentional ingestion of emamectin in an adult. A 53-year-old male presented to the emergency department with an alleged history of suicidal ingestion of emamectin benzoate 5% water soluble granules mixed with around 180ml of ethyl alcohol following which he developed vomiting and was immediately taken to a nearby hospital. Gastric lavage was performed; however, he succumbed to death the following day. The autopsy examination showed evidence of stomach mucosal erosions, alveolar oedema, and hepatic necrosis. Chemical analysis of viscera detected qualitatively the presence of emamectin benzoate in blood and tissues. Toxicological analysis of emamectin and its potential limitations was discussed. Death following emamectin poisoning in humans has been reported very little in the literature due to which its spectrum of clinical features is difficult to comment upon. Future case studies and literature will help better understand the range of clinical and autopsy features to aid the prompt diagnosis.
Methodology study of geothermal resource evaluation using remote-sensing and ground-surface temperature data, Burwash Landing, Yukon – status and preliminary results
Authors: Chen Z. , Grasby S. E. , Yuan W. , Colpron M. , Liu X.
Published: June 2024

Trouver des ressources énergétiques renouvelables pour atteindre les objectifs du gouvernement visant à atteindre zéro émission nette d’ici 2050 est l’un des plus grands défis auxquels nous sommes confrontés, en particulier dans le Nord. Les communautés du Nord sont en grande partie déconnectées du réseau énergétique nord-américain et dépendent plutôt des hydrocarbures importés pour leur chauffage et leur électricité. Une étude antérieure (par exemple Grasby et al., 2011) suggérait que le Yukon et le nord-est de la Colombie-Britannique constituaient des régions à fort potentiel pour les ressources géothermiques. Des travaux supplémentaires montrent le potentiel de l'énergie géothermique pour soutenir les communautés du Nord (Grasby et al., 2012). De nouvelles techniques de géophysique, de télédétection et de surveillance de la température de surface du sol (GST) pour l'évaluation géothermique ont été développées dans le cadre du projet géothermique Garibaldi (Grasby et al., 2021 ; Chen et al. 2023). Cette étude explore la faisabilité de l'utilisation d'images multispectrales de télédétection de Landsat 8 et des séries chronologiques GST du réseau de surveillance GST pour révéler la relation entre le système de failles profondes et le flux de chaleur souterrain en tant qu'outil d'évaluation des ressources géothermiques pour le nord du Canada. GSC et YSG ont déployé un réseau de surveillance de la température à la surface du sol au cours de l'été 2022, et les données de 65 stations ont été récupérées au cours de la saison de terrain 2023. Un traitement préliminaire a été effectué pour détecter les zones de flux de chaleur élevé. Deux ensembles d'images multispectrales Landsat-8 dans la zone de Burwash Landing de différentes saisons ont été collectées et traitées pour l'extraction de caractéristiques à l'aide d'algorithmes ML. Les données GST et les caractéristiques extraites des images Landsat ont été analysées pour déterminer si les anomalies géothermiques sont liées à des caractéristiques géologiques spécifiques, telles que des systèmes de failles profondes. Nous rapportons ici les résultats préliminaires en mettant l'accent sur l'analyse des données sur la TPS.
Effect of lipid emulsion on vasoconstriction induced by epinephrine or norepinephrine in isolated rat aorta
Authors: Lee Soo Hee , Park Kyeong-Eon , Eum Kibaek , Hwang Yeran , Ok Seong-Ho , Sim Gyujin , Perera Dumidu , Ravald Henri K.M. , Park Youngho , Wiedmer Susanne K. , Sohn Ju-Tae
Published: June 2024

Background: Epinephrine (EPI) or norepinephrine (NOR) is widely used to treat cardiovascular collapse during lipid emulsion (LE) resuscitation for drug toxicity. However, the effect of LE on the vasoconstriction caused by EPI or NOR remains unknown. The purpose of this study was to examine the effect of an LE (Intralipid) on the vasoconstriction caused by EPI and NOR in isolated rat aorta. Methods: The effect of LE on the vasoconstriction caused by EPI or NOR in isolated rat aorta was examined. Additionally, the effect of LE on the calcium increase caused by EPI or NOR was investigated. The distribution constant (KD: lipid to aqueous phase) of EPI or NOR between a LE (1%) and an aqueous phase was determined. Results: LE (1 and 2%) did not significantly alter vasoconstriction caused by EPI or NOR in isolated endothelium-intact aorta. Moreover, the LE did not significantly alter the increased calcium level caused by EPI or NOR. The log KD of EPI in the LE (1%) was −0.71, −0.99, and −1.00 at 20, 50, and 100 mM ionic strength, respectively. The log KD of NOR in the LE (1%) was −1.22, −1.25, and −0.96 at 20, 50, and 100 mM ionic strength, respectively.Conclusions: Taken together, the Intralipid emulsion did not alter vasoconstriction induced by EPI or NOR that seems to be due to the hydrophilicity of EPI or NOR, leading to sustained hemodynamic support produced by EPI or NOR used during LE resuscitation.
A Clinical Trial Registry - India audit of listed head-and-neck cancer trials and studies from 2008-2022: A retrospective study
Authors: Roy Soumya Kanti , Kumar Meghna , Goyal Prachi , Qayyumi Burhanuddin
Published: June 2024

Background:

Clinical trials are vital for advancing cancer treatment, but gaps exist in establishing ethical practices and transparency, especially in the context of head-and-neck cancers (HNCs) in India.

Objectives:

The primary objective of the study was to conduct a critical audit of the Clinical Trials Registry – India (CTRI) from 2008 to 2022; to quantify the number of studies and trials related to HNCs. Our secondary objective was to evaluate the credibility, accountability, and ethical advancements attributed to these registrations within India’s clinical research landscape.

Materials and Methods:

This was a retrospective study conducted between October 2022 and August 2023 at Homi Bhabha Cancer Hospital and Research Center, a tertiary cancer center in India. A thorough examination of the CTRI and PubMed databases was performed, encompassing 356 HNC trials registered at CTRI. Parallelly, 926 peer-reviewed publications from the leading clinical trial centers were assessed for credibility and accountability.

Results:

Of the 356 trials, 211 (59.3%) were interventional; however, 225 (63.2%) lacked explicit primary endpoints. Tata Memorial Center, Mumbai, India registered the maximum share with 98 (27.5%) trials registered during the period. Among the leading trial centers, notable discrepancy between CTRI registration and subsequent publication was observed, ranging from 2.2-8% across Tata Memorial Center (Mumbai), All India Institute of Medical Sciences (New Delhi), and Kasturba Medical College (Manipal).

Conclusion:

This audit exposed substantial ethical and transparency gaps, with a marked concentration in a few institutions within the Indian HNC clinical trials’ landscape. The study calls for urgent reforms to improve multi-institutional collaboration and ethical standards for enhanced human trials.
An objective cross-sectional assessment of ChatGPT in hematology-oncology manuscript composition: Balancing promise with factual inaccuracies
Authors: Singh Suvir , Prasad Pooja , Joshi Kaveri , Singh Jagdeep , Garg Nitish , Jain Kunal
Published: June 2024

Background:

Artificial intelligence (AI)-based large language models (LLMs), such as Chat Generative Pre-training Transformer (ChatGPT), exhibit promise in aiding manuscript composition and literature search, encompassing various research tasks. However, their utilization remains unregulated.

Objectives:

The primary objective of this study was to objectively assess the ability of ChatGPT 3.5 (free version) to assist with various tasks associated with manuscript preparation and research based on pre-defined scoring criteria. Secondary objectives included an assessment of the factual accuracy of data and any false information returned by ChatGPT.

Materials and Methods:

This cross-sectional study was planned in the Departments of Clinical Hematology and Medical Oncology of Dayanand Medical College and Hospital, Ludhiana, Punjab, India, a tertiary care referral center. Between July 1, 2023, and July 30, 2023, seven prompts comprising queries related to manuscript design, specific data, or complex discussion in hematology/oncology subjects were used. The responses were scored based on detailed pre-defined criteria for accuracy and completeness, and scoring was independently performed by a panel of five reviewers with current expertise in the field of hematology/medical oncology. Negative marking was performed for factual inaccuracies. Cronbach’s alpha and interclass correlation coefficient were calculated to assess inter-observer agreement.

Results:

ChatGPT readily provided information on the structural components of the manuscript and research design, with the ability to customize responses immediately. However, the presence of factual inaccuracies, fictional citations, and false information presented confidently were notable drawbacks. Cronbach’s alpha was 0.995, and the intraclass correlation coefficient was 0.995, indicating good inter-observer agreement. The overall score was 34.2 out of 90, with a poor score on the veracity of data and references.

Conclusion:

The current iteration of ChatGPT rapidly provides plausible and professional-looking information on up-to-date topics but is hindered by significant factual inaccuracies. Future research focusing on improving response accuracy and addressing ethical considerations of content generated by LLMs will help us maximize their potential in scientific paper development.
Lazertinib: A narrative drug review
Authors: Shaji Alan , Sharma Aparna
Published: June 2024

Epidermal growth factor receptor (EGFR) activating mutations are established drivers in non-small-cell lung cancer (NSCLC); 85% of these mutations are exon 19 deletion or exon 21 L858R point substitution. Lazertinib (YH-25448, JNJ-73841937, LECLAZA®) represents one of the latest oral third-generation EGFR-tyrosine kinase inhibitor (TKI) binding irreversibly to the Cys797 residue in the adenosine triphosphate (ATP)-binding site of the EGFR kinase domain, with high selectivity for EGFR mutations including T790M. To write this narrative review, we searched online portals of ScienceDirect, PubMed, and Google Scholar and various websites such as the United States Food and Drug Administration (US-FDA) and UpToDate, using the search terms “Lazertinib,” “YH-25448,” “JNJ-73841937,” and “NSCLC.” We shortlisted 30 articles published between January 2021 and December 2023, of which we included 10 articles. This review elaborates on the indications for use, side effects and safety profile, drug interactions, and pharmacokinetics and dynamics. Key evidence that investigated the use of lazertinib has also been discussed.
Correlation of prognosis of oral squamous cell carcinoma with CD44 expression: A retrospective immunohistochemical analysis
Authors: Nanda Kumar H , Vasanthi V , Gunasekaran Nandhini , Divya Bose , Annasamy Ramesh Kumar , Krishnan Rajkumar
Published: June 2024

Background:

Cluster of differentiation (CD44) is a cancer stem cell marker responsible for angiogenesis, invasion, and migration in oral squamous cell carcinoma (OSCC).

Objectives:

The primary objective of the study was to analyze the difference in expression of CD44 among different grades of OSCC. The secondary objective was to correlate the prognosis with the expression.

Materials and Methods:

Based on histopathological diagnosis, we retrieved OSCC paraffin-embedded blocks from the archives of the Department of Oral Pathology, Sri Ramaswamy Memorial (SRM) Dental College, Chennai, India, reported from January 2012 to May 2022. We evaluated sections from 15 tissues of normal oral mucosa, 15 paraffin blocks of well-differentiated OSCC, 15 moderately differentiated OSCC, and 15 poorly differentiated OSCC for CD44 immunostaining. Immunohistochemical expression of CD44 was studied in these tissues and graded based on the intensity of staining. The difference in immune expression of CD44 between different grades was quantitatively analyzed using image analysis by Fiji image analysis software. Analysis of variance (ANOVA) was used to compare the mean difference in expression between different groups by using the Statistical Package for Social Sciences (SPSS) software version 16. Statistical significance was set at P < 0.05.

Results:

We identified that 10% (n = 6) of the normal mucosa showed strong expression of CD44, whereas 13.3% (n = 8) of well-differentiated OSCC, 10% (n = 6) of moderately differentiated OSCC, and 0% (n = 0) of poorly-differentiated OSCC were strongly positive for CD44 expression. The difference in comparison was statistically significant (P, 0.003). By quantitative analysis, the mean expression of CD44-positive cells in well-differentiated OSCC was 38258 ± 4762, moderately-differentiated OSCC was 27353 ± 1357, and poorly-differentiated OSCC was 10265 ± 1685. Upon comparison, the difference in mean was found to be significant (P, 0.002).

Conclusion:

The expression of CD44 was noted to decrease from well-differentiated to poorly-differentiated OSCC.
Pathways to Psychiatric Help among Tribal Patients with Mental Disorders in India
Authors: Subudhi Chittaranjan , Biswal Ramakrishna , Pathak Abhijit
Published: June 2024

ABSTRACT

Background:

The pathways of mental illness treatments are mostly uncertain. Previous studies have agreed on sociodemographic and cultural factors in determining a patient’s and their family’s health-seeking pathways.

Methods:

However, the present study aims to understand the health-seeking pathways of less explored tribal population and their path of resorting to medical professionals. Fifty tribal patients were selected from the Department of Psychiatry, Ispat General Hospital, Rourkela, Odisha, India, through a convenience sampling technique. A structured interview schedule was used to record the respondent’s responses.

Results:

Results came up with 90% of tribal patients visit medical professionals for a speedy recovery, whereas 82% of patients and their families believe in the easy availability of traditional healers, and 55% think that allopathy is unsuccessful in treating mental illness.

Conclusions:

Thus, it makes traditional healers the first choice of treatment. Future studies should try to bring traditional and medical practitioners under one roof to ascertain the patient recovery rate and contribution in removing patient’s load from tertiary care.
Compassion Fatigue and Compassion Satisfaction Among Nursing Officers
Authors: Sharma Parul , Shaiju Bindu , Rahman Jahanara , Singh Dharmander
Published: June 2024

ABSTRACT

Introduction:

Nurses make up the largest group of health-care workers, so it is important to rule out compassion fatigue (CF) and compassion satisfaction among nursing officers.

Methodology:

A descriptive study was adopted, and purposive sampling technique was used. The present study’s sample included 134 nursing officers. The data were gathered in January 2022 using the Structured CF Scale and the Structured Compassion Satisfaction Scale. The data were analyzed using descriptive and inferential statistics.

Results:

The findings of the research revealed that the majority of the nursing officers had a moderate level of CF in terms of burnout and secondary traumatic stress and moderate level of compassion satisfaction while taking care of patients suffering from COVID-19. The findings of the present study also revealed that there was no significant relationship between CF in terms of burnout and secondary traumatic stress and compassion satisfaction, but a negative and weak correlation was evident. It was found that there was no significant association between CF in terms of burnout with selected demographic variables. It was also found that there was a significant association between CF in terms of secondary traumatic stress with age and there was no significant association between compassion satisfaction with demographic variables.

Conclusion:

It was found that the majority of nursing officers were highly satisfied with their jobs and they were found to be more compassionate during this pandemic.
A combinatorial higher-rank hyperbolicity condition
Authors: Jørgensen Martina , Lang Urs
Published: June 2024

We investigate a coarse version of a

2(n+1)

-point inequality characterizing metric spaces of combinatorial dimension at most 

n

due to Dress. This condition, experimentally called

(n,\delta)

-hyperbolicity, reduces to Gromov’s quadruple definition of

\delta

-hyperbolicity in case

n = 1

. The

l_{\infty}

-product of

n

\delta

-hyperbolic spaces is

(n,\delta)

-hyperbolic. Every

(n,\delta)

-hyperbolic metric space, without any further assumptions, possesses a slim

(n+1)

-simplex property analogous to the slimness of quasi-geodesic triangles in Gromov hyperbolic spaces. In connection with recent work in geometric group theory, we show that every Helly group and every hierarchically hyperbolic group of (asymptotic) rank

n

acts geometrically on some

(n,\delta)

-hyperbolic space.
Cohort profile: the Taiwan Initiative for Geriatric Epidemiological Research - a prospective cohort study on cognition
Authors: Hsieh Pei-Iun , Huang Te-Hsuan , Chiou Jeng-Min , Chen Jen-Hau , Chen Yen-Ching
Published: June 2024

The Taiwan Initiative for Geriatric Epidemiological Research (TIGER) was founded in 2011 to elucidate the interrelationships among various predictors of global and domain-specific cognitive impairment, with the aim of identifying older adults with an increased risk of dementia in the preclinical phase. TIGER, a population-based prospective cohort, recruited 605 and 629 (total of 1,234) older adults (aged 65 and above) at baseline (2011-2013 and 2019-2022) of phase I and II, respectively. Participants have undergone structured questionnaires, global and domain-specific cognitive assessments, physical exams, and biological specimen collections at baseline and biennial follow-ups to date. By 2022, TIGER I has included 4 biennial follow-ups, with the participants comprising 53.9% female and having a mean age of 73.2 years at baseline. After an 8-year follow-up, the annual attrition rate was 6.1%, reflecting a combination of 9.9% of participants who passed away and 36.2% who dropped out. TIGER has published novel and multidisciplinary research on cognitive-related outcomes in older adults, including environmental exposures (indoor and ambient air pollution), multimorbidity, sarcopenia, frailty, biomarkers (brain and retinal images, renal and inflammatory markers), and diet. TIGER’s meticulous design, multidisciplinary data, and novel findings elucidate the complex etiology of cognitive impairment and frailty, offering valuable insights into factors that can be used to predict and prevent dementia in the preclinical phase.
Concentration and Characterisation with Spectroscopic Technique of Microplastics in the Surface Sediment and Commercial Fish Species of Gemlik Bay (Marmara Sea)
Authors: Yücedağ Elif , Mülayim Ayşegül , Gündüz Serda Kecel
Published: June 2024

In this study, we aimed to evaluate and characterise the microplastic pollution in the sediment and commercial fish species in the Gemlik Bay, the Marmara Sea. Our results showed that the highest concentration of microplastics in the sediment was at the station in the Gemport Harbour (9.73 pieces.kg-1) and the lowest concentration was at the Kurşunlu offshore (3.33 pieces.kg-1). The highest microplastic concentration per individual was in the gills of Synapturichthys kleinii (Risso, 1827) (14.5 pieces.ind-1) and the lowest in Diplodus annularis (Linnaeus, 1758) (0.33 pieces.ind-1). The highest concentration (8.75 pieces.ind-1) was indicated in the gastrointestinal tract of Chelidonichthys lucerna (Linnaeus, 1758), but the lowest concentration (0.88 pieces.ind-1) was in that of D. annularis species. The fiber-type particles were the most determined microplastics in both the sediment and fish samples. The Micro-Raman Spectrometer revealed that Polyvinyl chloride and polypropylene were dominant in the sediment, and polyoxymethylene and polyphenylene sulfone polymers were dominant in fish species.
METHODS OF TEACHING YOUNG PEOPLE, DEVELOPMENT OF SPEECH FUNCTIONS AND GENERAL KNOWLEDGE OF THE WORLD
Authors: Vladlenov Denis , Апанасенко Андрій , Тищенко Валерія , Дядечко Ігор , Конох Анатолій , Конох Андрій , Конох Олена , Товсто’пятко Федір , Solomnikova Kateryna , Polovina Olena , Венгловська Олена , Дем’яненко Валентина , Марамуха Наталія , Тищенко Валерія , Вєрітов Олександр , Олексюк Наталія , Гукалюк Андрій , Kalenyk Mykhailo , Yurko Nadiia , Romanchuk Olha , Kholiavka Volodymyr , Danylevych Myroslava , Musikevych Taras
Published: June 2024

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REKLAMCILIĞIN DÖNÜŞÜMÜ BAĞLAMINDA GELENEKSELDEN DİJİTALE REKLAMIN SERÜVENİ: ZİRAAT BANKASI REKLAMLARI ÖRNEĞİ
Authors: Çağlar Demir Bilge
Published: June 2024

Reklam, ortaya çıktığı ilk dönemden itibaren kitleleri ürün ya da hizmet hakkında bilgilendirme ve satın alma eylemine yönlendirmek amacıyla kullanılan önemli bir iletişim aracı olmuştur. Yıllar içinde yaşanan teknolojik gelişmeler sonucunda çok daha çeşitli araç ve yöntemlerle kitlelerle buluşan reklam aynı zamanda içinde bulunulan döneminde koşul ve özelliklerini yansıtan bir ayna görevi de görmektedir. Bu çalışma, literatür taramasıyla elde edilen bilgiler ışığında reklamcılığın gelişim sürecini irdeleyerek, dijitalleşen yeni reklam anlayışını açığa çıkarmaktadır. Bu temelde çalışmanın amacı, reklamın ülkemizde geçmişten günümüze hangi dönemlerden geçtiğini, geçmiş ve şu anki reklam mecralarının ve reklam biçimlerinin nasıl değiştiğini ortaya çıkarmaktır. Bu doğrultuda tarihi II. Abdülhamit’e kadar uzanması ve reklamcılığın gelişim sürecini anlatabileceği düşüncesinden hareketle Ziraat Bankası örneklem olarak seçilmiştir. Çalışmada, reklamların incelenmesi için betimsel araştırma yöntemi tercih edilmiş ve bankanın gazete ve instagram reklamları bu yöntemle incelenmiştir. Gazetelerde yayımlanmış reklamların analizinde; görsel öğeler, kullanılan dil, iletilen mesaj ve dönemsel koşullar gibi faktörler ele alınmıştır. Instagram reklamlarının analizinde ise, ses, görüntü, video, animasyon ve metin gibi çeşitli parametreler üzerinden değerlendirme yapılmıştır. Ziraat Bankasının geçmişten günümüze yayınlamış olduğu reklamların taranması sonucu gerçekleştirilen analizde; dönemin sosyo-ekonomik koşullarının ve yaşanan teknolojik gelişmelerin reklamlara yansıdığı saptanmıştır. Bu analizle aynı zamanda ülkemizdeki reklamcılığın dönüşümünü izleme açısından da önemli bulguların ortaya konulacağı düşünülmektedir.
“Berit” sebagai Bentuk Cinta Tuhan yang Mengikat kepada Manusia dalam Perspektif Gabriel Marcel
Authors: Pakpahan Abraham
Published: June 2024

Pembahasan mengenai cinta selalu menjadi topik hangat ketika diangkat menjadi bahan diskusi. Menarik untuk mengetahui apakah konsep cinta memiliki sifat yang membebaskan seseorang atau justru cinta itu memiliki sifat yang mengikat. Penelitian ini berusaha untuk memperlihatkan keberpihakannya kepada sifat cinta yang mengikat. Kata בְּרִית (berit) digunakan dalam penelitian ini untuk menunjukkan bahwa perjanjian yang dilakukan Tuhan dengan manusia merupakan sifat cinta Tuhan adalah mengikat. Metode penelitian secara semantik dalam berbagai penggunaan narasi Alkitab dan tafsiran membantu penelitian ini untuk mengetahui konsep penggunaan kata tersebut. Pemikiran filsuf Gabriel Marcel memperkaya penelitian ini untuk menunjukkan eksistensialisme manusia dalam merespons cinta yang diberikan Tuhan kepada manusia dan hubungan yang diberikan manusia kepada Tuhan. Berit memberikan cinta yang Tuhan berikan kepada manusia sehingga ada manusia memiliki pengharapan dan menjadikan Tuhan satu-satunya jalan keluar.
DIFERENTES CONCEITOS E PENSAMENTOS NO ENTENDIMENTO DA AVALIAÇÃO DA APRENDIZAGEM ESCOLAR
Authors: Mafra Mackson Azevedo , Almeida Alessandra Barboza Barros , Hungaro Fernanda , Rezende Guelly Urzêda de Mello , Caiado Magno Antonio Cardozo
Published: June 2024

Esta investigação apresenta um estudo sobre a avaliação a partir dos diferentes pensamentos de teóricos, bem com dá experiencia profissional adquirida pelos professores em pleno gozo de suas trajetórias pedagógicas. Para a elaboração desta pesquisa foi adotada a abordagem quantitativa tendo com enfoque a pesquisa exploratória descritiva, pois está foi uma forma de estudo apropriada que permitiu a compreensão e interpretação de algumas questões educacionais envolvendo a avaliação da aprendizagem no ambiente escolar. A avaliação é um tema presente e que ainda precisa ser bastante discutido, pois não existe um modelo pronto e acabado a ser seguido pelos docentes. Partindo desse pressuposto, a presente pesquisa aborda os desafios e as possibilidades da avaliação, onde se buscou conhecer os diferentes conceitos e pensamentos que permeiam o entendimento da temática abordada. Neste trabalho, percebeu-se a necessidade de tornar abrangente a discussão acerca da avaliação escolar, haja vista que seu uso pode contribuir de forma significativa para a melhoria da aprendizagem, tendo em vista o acompanhamento contínuo de todo o processo do conhecimento do aluno, além da colaboração nos planejamentos pedagógicos e institucionais condizentes com a realidade e a necessidade dos estudantes.
Planning, Analysis and Design of Thermal Comfort Auditorium in KMCT Technical Campus
Authors: V Arya K , . Hiba , V Ms Sindhu , PC Ayisha Nasli , Kutty UC Ahammed
Published: June 2024

The project deals with the planning, analysing and designing a proposed auditorium for KMCT Technical Campus. The proposed site is located in Kalanthode, Calicut district. The building is three-storey (G+2) and is designed as a framed structure. The concrete mix used for the RCC structure is M20, and the steel used is high-yield strength deformed bars of grade Fe415. The functional planning uses Kerala PANCHAYATH BUILDING RULE and INDIAN STANDARD CODES. The structure shall be designed to resist and bear all loads liable to act on it. The plan is drafted using AUTOCAD software, and an analysis is performed using STAAD.Pro software. The project is based on the limit state method. The goal of this project is to create a cutting-edge auditorium that can accommodate the various needs of contemporary audiences. The main goals are to design a flexible venue that can accommodate a range of activities, such as concerts, conferences, theatre shows, and community meetings, while maintaining the best possible acoustics, accessibility, and sustainability.
Terracotta to Terraces: Tracing the Unique Temple Architecture of Bengal
Authors: Akhter Nasrin , Rasheed Ar. Sazzadur , Ibne Iqbal Mian Md Jawad
Published: June 2024

This paper explores the diverse architectural styles of temple construction in Bengal from the 9th to the 19th centuries. Through a detailed examination of structural variations and decorations, the study highlights how the intermingling of Hindu, Islamic, and later European influences shaped the distinctive temple architecture in this region. The research uses architectural analysis and historical texts to identify key styles, such as the 'do-chala' and 'char-chala' huts, alongside the more ornate 'Ratna' and 'naba-ratna' structures. These styles reflect the religious and cultural synthesis and the geographical and material constraints influencing temple architecture in Bengal. The findings underscore the role of Gaudiya Vaishnavism and regional patronage in fostering a unique architectural heritage characterized by its terracotta embellishments and innovative structural forms. This study contributes to a deeper understanding of South Asian architectural diversity and its socio-religious contexts, offering insights into the region's broader patterns of cultural interchange.
The effect of green data center and its implications on academia
Authors: G Ramesh Babu  , Dr. Manish Dwivedi
Published: June 2024

The research paper would give us the purpose in which the green data center impact on the academia as an industry and how effectively the measures can be taken by the respective institution to reduce the environmental hazards that can be harmful for the society. The impact that is of more meaning can be done at four pillars Renewable Energy, Energy Efficiency, Infrastructure usage and Water Usage. The deployment of the greenfield in terms of design , configuration and installation where none existed before. The advantages of having the proper infrastructure to make use of optimal resources in a viable manner when ever is required there by contributing significantly to the environment.The usage of the latest trends of the computing environment is taken into consideration with respect to the current infrastructure to the institution of the firm would be studied upon. And the usage of the current infrastructure and the regulations about the rules that are adopted by the respective institutions would be studied. The IT infrastructure model and the role that many academia institutions are following are been studied upon with the secondary data with the help of different resources. Keeping in the view of the data center and implications the study would be mentioned in the findings about the impact at which it can be given is called as give to the organization positive.
a Study On Diversity And Status Of Avifauna In Kukkarahalli Lake: Mysuru, Karnataka, India
Authors: Apsara.V  , Kavya B.R
Published: June 2024

Birds are highly diverse and conspicuous species of the environmental ecosystem. And act as potential bio-indicators. The present study deals with the diversity and status of avian species. The survey carried out from March 2023 to July 2023 in the Kukkarahalli Lake, Mysuru. A total 85 species of avifauna belonging to 17 orders and 40 families has been recorded in study area by using Line transect method, The order Passeriformes has the most species (37 species), whereas the orders Bucerotiformes, Galliformes, Podicipediformes, Psittacciformes and Strigiformes have the fewest species (1species each). Among the recorded species 64 (75%) species were Resident and 21 (25%) species were resident migratory. The result of relative diversity (RD) showed that Ardeidae (RD Index value= 9.523), was the dominant family. The present study provides baseline information for the bird diversity in and around study area and is a preliminary effort to assess species richness and the avifaunal diversity of Kukkarahalli Lake.