bluuebunny/crossref_metadata_2025 huggingface dataset:
The Dynamic Effects of Urban–Rural Income Inequality on Sustainable Economic Growth under Urbanization and Monetary Policy in China
Authors: Cheng Junli , Lin Feng
Published: June 2022

Income inequality in China has become increasingly serious since the beginning of the economic reform period in the 1970s, with urban–rural income inequality playing a large role. Urbanization policy and monetary policy are currently important economic policy tools for the Chinese government. In order to investigate the influence of inequality on the economy and to provide recommendations for ensuring the sustainability of growth, we study the effect of urban–rural income inequality on economic growth in the context of urbanization and monetary policy in China between 2002 and 2021. Using a flexible time-varying parametric structural vector auto-regression (TVP-VAR) model and a robust Markov chain Monte Carlo (MCMC) algorithm, our empirical results show that the effect is time-varying, with inequality promoting growth in the early years but affecting it adversely at later stages. Currently, urbanization mitigates inequality and promotes growth simultaneously, while easy monetary policy worsens inequality and affects growth adversely in the long term. We suggest that the authorities need to consider the implementation of policy rebalancing to ensure that the sustainability of economic development is not jeopardized because of worsening income disparity. Proactive urbanization policy and prudent monetary policy are viable rebalancing options.
Epidemiological Interface of Sylvatic and Dog Rabies in the North West Province of South Africa
Authors: Malan Ayla J. , Coetzer Andre , Sabeta Claude T. , Nel Louis H.
Published: June 2022

Rabies is a viral zoonosis that causes an estimated 59,000 preventable human fatalities every year. While more than 120 countries remain endemic for dog-mediated rabies, the burden is the highest in Africa and Asia where 99% of human rabies cases are caused by domestic dogs. One such rabies-endemic country is South Africa where an estimated 42 preventable human deaths occur every year. Although canine rabies had been well described for most of the provinces in South Africa, the epidemiology of rabies within the North West Province had not been well defined prior to this investigation. As such, the aim of this study was to use nucleotide sequence analyses to characterise the extant molecular epidemiology of rabies in the North West Province of South Africa—with specific focus on the interface between dogs and sylvatic species. To this end, Rabies lyssavirus isolates originating from the North West Province were subjected to molecular epidemiological analyses relying on the Bayesian Markov Chain Monte Carlo methodology on two distinct gene regions, viz. the G-L intergenic region and partial nucleoprotein gene. Our results provided strong evidence in support of an endemic cycle of canine rabies in the East of the province, and three independent endemic cycles of sylvatic rabies spread throughout the province. Furthermore, evidence of specific events of virus spill-over between co-habiting sylvatic species and domestic dogs was found. These results suggest that the elimination of canine-mediated rabies from the province will rely not only on eliminating the disease from the dog populations, but also from the co-habiting sylvatic populations using oral rabies vaccination campaigns.
Continuous Circulation of Chikungunya Virus during COVID-19 Pandemic in Jambi, Sumatra, Indonesia
Authors: Santoso Marsha Sinditia , Haryanto Sotianingsih , Rulian Fadil , Hayati Rahma F. , Kristiani Amanda , Kartika Rini , Yohan Benediktus , Hibberd Martin L. , Sasmono R. Tedjo
Published: June 2022

Chikungunya fever is a self-limiting viral illness that is caused by the chikungunya virus (CHIKV). CHIKV is found in multiple provinces of Indonesia, with clustered local outbreaks. This case series investigates a local chikungunya outbreak during the COVID-19 pandemic, involving two virologically confirmed chikungunya cases found in Jambi, Sumatra, Indonesia in 2021 and the contact tracing of 65 people from the same neighborhood (one of which was also virologically confirmed with CHIKV). The two original cases were symptomatic with classic signs of chikungunya fever, while the CHIKV-positive neighbor was asymptomatic. Out of the 65 participants, chikungunya IgM was detected in seven (10.8%) people while chikungunya IgG was detected in six (9.2%) using capture ELISA. Dengue IgG was detected by rapid test in three (4.6%) of the participants, showcasing a history of dengue virus (DENV) infection along with the circulation of CHIKV in the area. A phylogenetic analysis demonstrates a close evolutionary relationship between all three 2021 Jambi CHIKV isolates and the 2015–2016 isolates from Jambi. This case series showcases the endemicity and persistent circulation of CHIKV in Jambi, leaving the area vulnerable to eminent outbreaks of chikungunya fever and doubling the burden of disease during the COVID-19 pandemic. Health staff training for case detection and notification, as well as an integrated vector surveillance should continue to be implemented to provide an early warning indicator of possible chikungunya outbreaks.
Shape Invariant Potentials in Supersymmetric Quantum Cosmology
Authors: Jalalzadeh Shahram , Rasouli Seyed Meraj M. , Moniz Paulo
Published: June 2022

In this brief review, we comment on the concept of shape invariant potentials, which is an essential feature in many settings of N=2 supersymmetric quantum mechanics. To motivate its application within supersymmetric quantum cosmology, we present a case study to illustrate the value of this promising tool. Concretely, we take a spatially flat FRW model in the presence of a single scalar field, minimally coupled to gravity. Then, we extract the associated Schrödinger–Wheeler–DeWitt equation, allowing for a particular scope of factor ordering. Subsequently, we compute the corresponding supersymmetric partner Hamiltonians, H1 and H2. Moreover, we point out how the shape invariance property can be employed to bring a relation among several factor orderings choices for our Schrödinger–Wheeler–DeWitt equation. The ground state is retrieved, and the excited states easily written. Finally, the Hamiltonians, H1 and H2, are explicitly presented within a N=2 supersymmetric quantum mechanics framework.
New p35 (H3L) Epitope Involved in Vaccinia Virus Neutralization and Its Deimmunization
Authors: Khlusevich Yana , Matveev Andrey , Emelyanova Lyudmila , Goncharova Elena , Golosova Natalia , Pereverzev Ivan , Tikunova Nina
Published: June 2022

Vaccinia virus (VACV) is a promising oncolytic agent because it exhibits many characteristic features of an oncolytic virus. However, its effectiveness is limited by the strong antiviral immune response induced by this virus. One possible approach to overcome this limitation is to develop deimmunized recombinant VACV. It is known that VACV p35 is a major protein for B- and T-cell immune response. Despite the relevance of p35, its epitope structure remains insufficiently studied. To determine neutralizing epitopes, a panel of recombinant p35 variants was designed, expressed, and used for mice immunization. Plaque-reduction neutralization tests demonstrated that VACV was only neutralized by sera from mice that were immunized with variants containing both N- and C- terminal regions of p35. This result was confirmed by the depletion of anti-p35 mice sera with recombinant p35 variants. At least nine amino acid residues affecting the immunogenic profile of p35 were identified. Substitutions of seven residues led to disruption of B-cell epitopes, whereas substitutions of two residues resulted in the recognition of the mutant p35 solely by non-neutralizing antibodies.
Three-Dimensional Model of Soil Water and Heat Transfer in Orchard Root Zone under Water Storage Pit Irrigation
Authors: Su Yuanyuan , Guo Xianghong , Lei Tao , Zheng Lijian , Ma Juanjuan , Sun Xihuan , Hao Linru , Hu Feipeng
Published: June 2022

To reveal the water and heat transfer characteristics of the orchard soil under water storage pit irrigation and to regulate the distribution of soil water and heat for improving apple quality and increasing yield, a 3D soil water and heat transfer model of orchards under water storage pit irrigation was established. The model not only considered the influences of root water uptake, precipitation, evaporation, and irrigation, but also simulated the infiltration process of the variable water head in the pit according to the principle of mass conservation and introduced the pit coefficient to simulate the difference in radiation in the pit to describe the influence of the pit on the model. Verify and analyze the simulation results. Results showed that the variation trend of simulated soil moisture and heat was consistent with that of measured data. The mean absolute percentage error, root mean square error, and mean absolute deviation were 3.23%, 0.9460, and 0.6984 for soil temperature and 10.05%, 0.0269, and 0.0214 for water content after irrigation, respectively. The simulation results have high accuracy and show that the soil moisture content centers on the pit with an ellipsoid distribution and tends to be uniform over time. The soil temperature was higher in the 4–5 cm area near the soil surface and the wall of pit, and it remarkably changed with time. The intraday variation of soil temperature was mainly affected by atmospheric temperature, but a certain lag was observed compared with the change of atmospheric temperature. With the increase of the irrigation amount, the distribution range of soil moisture content and water high value area increased, while the average and maximum soil temperature decreased. With the increase of irrigation water temperature to 18–24 h after irrigation, the soil temperature in the ellipsoidal area around the pit remarkably increased. The model established in this paper can be used to simulate the hydrothermal status of the soil in the field under water storage pit irrigation. The results prove that the water storage pit irrigation can effectively improve the hydrothermal status of the middle-deep soil and promote the root system of fruit trees to absorb water.
Features of the modern classification of canned fish
Authors:   Russian Customs Academy, Krishtafovich V.I. , Murtazina K.R. ,   Russian Customs Academy
Published: June 2022

The article analyzes the features of the modern classification of canned fish based on the analysis of existing regulatory documents, as well as according to the Commodity Nomenclature of Foreign Economic Activity of the Eurasian Economic Union. The lack of harmonization of the classification of canned fish in domestic trade and for customs purposes, as well as differences in the terminology used, was revealed.
A new variety of flat bread and its development prospects
Authors:   Plekhanov Russian University of Economics, Borisevich A.V.
Published: June 2022

The article describes a new variety of flat bread for the Russian market — tortillas, which are common abroad. The characteristics of tortillas are given; a comparison with lavash is made. Most of the tortilla brands on the market are imported, which makes it promising to develop the production of this type of flat bread in Russia. The prospects for the development of tortillas assortment in Russia are described.
Apocalyptic worldview and its reflection in the cinema of the 20th century
Authors:   Moscow University for the Humanities, Kirsanova Anna Vladimirovna
Published: June 2022

The article traces the formation and development of the apocalyptic genre and its embodiment in various directions: literature and cinema (on the example of the USSR and Russia). The analysis of ideas, images of heroes in cinema is carried out, and the relevance of fears that formed the basis for films in every period of history is emphasized. On the basis of a catastrophic worldview, the features inherent in Russian and Soviet cinema are revealed, and the evolution of meaning, ideas and images in the films of the Soviet period and modern films is traced.
Productivity of quails when introduced in compound feed of beech flour
Authors:   Siberian Scientific and Research Institute of Poultry – a branch of the Federal State Budget Scientific Institution “Omsk Agrarian Scientific Center”, Russia, Omsk Region, Morozovka, Shpуnova S. A. , Yadrishchenskaya O. A.\ ,   Siberian Scientific and Research Institute of Poultry – a branch of the Federal State Budget Scientific Institution “Omsk Agrarian Scientific Center”, Russia, Omsk Region, Morozovka, Selina T. V. ,   Siberian Scientific and Research Institute of Poultry – a branch of the Federal State Budget Scientific Institution “Omsk Agrarian Scientific Center”, Russia, Omsk Region, Morozovka, Basova E. A. ,   Siberian Scientific and Research Institute of Poultry – a branch of the Federal State Budget Scientific Institution “Omsk Agrarian Scientific Center”, Russia, Omsk Region, Morozovka
Published: June 2022

In many countries, quail breeding is organized on a large scale, using modern industrial forms of production. Due to quail farming, the range of dietary foodstuff s necessary for a person is expanding. When rearing and housing this species of poultry, its complete feeding is of particular importance, because health and productivity depend not only on the presence of protein, energy, fats in the compound feed, but also on the amount and ratio of minerals in it, which are a necessary component of any diet. The introduction of beech fl our containing lignocellulose, which relatively recently began to be used for animal feeding as a source of high-quality dietary fiber, can increase the availability of feed nutrients. The purpose of the research was to study the influence of compound feed with the introduction of 1 % beech fl our in different rearing periods on the metabolism and productivity of quails. The results of the influence of complete nutrient-balanced compound feed with beech fl our on zootechnical and economic indicators in the rearing of quailshave been presented in the article. It has been found that expenditures of feed per 1 kg of live weight gain of poultry of the experimental groups were lower by 3,10 % due to better absorption of nutrients. The live weight of quails in the control group at the age of 42 days was 348,25 g and was lower than in the experimental groups by 0,81 and 0,75 %. It has been established that the use of compound feed with 1 % beech fl our is of practical importance in connection with the increase in the productivity of quails and the level of profitability of meat production by 3,2 and 5,5 abs.%.
Influence of the genotype of sires on zinc concentration in the muscle tissue of offspring
Authors:   Federal State Budgetary Educational Institution of Higher Education “Novosibirsk State Agrarian University”, Russia, Novosibirsk, Narozhnykh K. N.
Published: June 2022

The selection of sires whose off spring are predisposed or resistant to the accumulation of chemical elements in muscle tissue is especially relevant for geochemical provinces with abnormal concentrations of trace elements. The concentration of zinc in the muscle tissue of 34 steers who were off spring of four sires of Holstein breed has been studied. Muscle tissue has been taken from a diaphragm weighing 100 g. The zinc level in the meat of steers was determined by atomic emission spectrometry with inductively coupled plasma on an IRIS Advantage spectrometer. The animals were housed in the Promyshlenskyareain the Kemerovo region under the same environmental conditions. Due to the small number of variants among the off spring of the sire Bonaer, robust indicators of descriptive statistics were calculated. In order to identify the influence of the genotype of sires on the level of zinc in the muscle tissue of off spring the Kraskell-Wallis criterion has been used. Median values of zinc levels in muscle tissue in the off spring of sires Bonaer, Brio, Malstrom and Fabio were 37, 46, 45 and 64 mg/kg, respectively. On this basis, the off spring of sires can be grouped into a ranked series: Bonaer< Brio
Comprehensive evaluation of pig breeding herds of Yorkshire breed on development and productivity in the Republic of Belarus
Authors:   Republican Unitary Enterprise “The Scientific and Practical Center of the National Academy of Sciences of Belarus for Animal Husbandry”, Republic of Belarus, Minsk region, Zhodino, Balnikov A. A. , Kostomakhin N. M. ,   Federal State Budgetary Educational Institution of Higher Education “Russian State Agrarian University – Moscow Timiryazev Agricultural Academy”, Russia, Moscow, Kazutova Yu. S. ,   Republican Unitary Enterprise “The Scientific and Practical Center of the National Academy of Sciences of Belarus for Animal Husbandry”, Republic of Belarus, Minsk region, Zhodino, Yanel I. P. ,   Ministry of Agriculture and Food of the Republic of Belarus, Republic of Belarus, Minsk, Gridyushko E. S. ,   State Enterprise “ZhodinoAgroPlemElita”, Republic of Belarus, Minsk region, Smolevichskyarea, Barsuki
Published: June 2022

The purpose of the work was a comprehensive evaluation of breeding herds of pigs of Yorkshire breed for development and productivity in the Republic of Belarus. It has been found as a result of the research that the growth and development of Yorkshire boars at the age of 36 months the best results in animals bred in the State Enterprise “ZhodinoAgroPlemElita” and in the Center for Breeding and Genetics in pig breeding RUAE “Grodnenskoe plempredpriyatie” have been shown (live weight was 302 and 303 kg, body length was 184–186,2 cm, which was 12–19,9 kg and 2,2–8,2 cm higher compared to animals of other breeding enterprises). The evaluation of the quality of sperm production on average has shown that the volume of ejaculate was 393,3 ml, the concentration of sperm was 618 million/ml, and the mobility of sperm was 8,62 points. The average percentage of fertility rate by actual farrowing was 89,5 %. When studying the productive traits of sows of Yorkshire breed in basic breeding enterprises, the animals bred in ZAO “Vitebskagroproduct” were distinguished by the best indicator of prolificacy(14,4 heads). In terms of milk producing ability the highest indicator was observed in animals bred in ZAO “Vitsebskagroproduct” and Collective Farming Unitary Enterprise “Chernyakhovsky-Agro” (63,4–68,2 kg), which was 15,1–23,7 % higher than in sows in State Enterprise “ZhodinoAgroPlemElita”. Piglets obtained at Collective Farming Unitary Enterprise “ChernyakhovskyAgro” and State Enterprise “ZhodinoAgroPlemElita” were distinguished by a high weight of one piglet at weaning in comparison with piglets on average in breed. When evaluation the indicators of their own productivity of breeding animals, the following average values were established: the age of reaching a live weight of 100 kg was 176,5 days, the average daily gain in live weight from birth to reaching the live weight of 100 kg was 559,7 g. The best indicators were the young animals reared in the State Enterprise “ZhodinoAgroPlemElita”. Thus, the age of reaching the live weight of 100 kg here was 7,0–9,4 days higher or 3,93–5,73 % than in young animals of other farms.
Influence of feed additives on the digestibility and use of nutrients in the diet of calves in the preweaning period of rearing
Authors:   Federal State Budgetary Educational Institution of Higher Education “South Ural State Agrarian University”, Russia, Chelyabinsk region, Troitsk, Ovchinnikov A. A. , Ovchinnikova L. Yu. ,   Federal State Budgetary Educational Institution of Higher Education “South Ural State Agrarian University”, Russia, Chelyabinsk region, Troitsk, Matrosova Yu. V. ,   Federal State Budgetary Educational Institution of Higher Education “South Ural State Agrarian University”, Russia, Chelyabinsk region, Troitsk, Erenko E. N. ,   Federal State Budgetary Educational Institution of Higher Education “South Ural State Agrarian University”, Russia, Chelyabinsk region, Troitsk
Published: June 2022

Optimization of the diet of animals taking into account biogeochemical provinces is important in the issue of their complete feeding, especially in the first months of postnatal development. There is a shortage of nutrients such as manganese, cobalt, iodine, zinc and copper in feed most often in the Ural region. The purpose of the research was to compare the influence of the phytomineral complex Vitafit with biogenic elements and the amylolytic enzyme Glucolyux F when they were included in the diet of calves in the preweaning period of rearing. The inclusion in the diet of calves of the phytomineral complex Vitafit with biogenic elements from alfalfa hay containing mineral salts of manganese, copper, cobalt, zinc and iodine at a dose of 100 ml/head/day, as well as the enzyme Glucolux F at the rate of 0,50 kg/t of compound feed with their separate use had a less noticeable influence on digestibility nutrients of the diet in comparison with their complex feeding. Which allowed to increase the digestibility of crude protein by 3,35 abs.%, fat by 3,02, fiber by 6,35 and nitrogen-free extractive substances by by 1,81 abs.% in comparison with analogues of the control group. In the body of calves in the group with the combined use of the phytomineral complex and the enzyme, nitrogen deposition was higher by 14,2 %, and calcium and phosphorus, respectively, by 12,7 and 16,7 %. Higher retention of nutrients in the diet of calves with the combined use of the phytomineral complex and the enzyme increased the absolute gain in live weight of calves by 6,3 %, while with when they were fed separately, the increase did not exceed 3,1 and 4,2 %. A higher live weight of calves in the group with a complex additive reduced expenditures of feed per unit of increase by 0,5–4,6 %, with one phytomineral complex it was by 1,2–1,8 %, with an amylolytic enzyme by 1,9–3,1 %.
The effectiveness of feeding selenium-containing additive on milk productivity, milk quality and reproductive ability of cows
Authors:   Federal State Budgetary Educational Institution of Higher Education “Belgorod State Agrarian University named after V. Ya. Gorin”, Russia, Belgorod Region, Belgorod area, Maysky, Kornienko P. P. , Vitkovskaya V. P. ,   Federal State Budgetary Educational Institution of Higher Education “Belgorod State Agrarian University named after V. Ya. Gorin”, Russia, Belgorod Region, Belgorod area, Maysky
Published: June 2022

The modern market poses new challenges to feed producers such as control over the general use of antibiotics and veterinary drugs is being tightened, the demand for environmentally friendly products is growing, which will be able to solve the problem of the deficiency of a number of trace elements noted in different regions. We took attention to the possibility of using organic and chelated forms of trace elements obtained by enzymatic hydrolysis of plant proteins and reactions with trace elements with high bioavailability and bioactivity, which contributes to an increase in productive indicators and parameters of reproduction ability of the herd and quickly turn into products. The purpose of the research was to study the effectiveness of feeding Selsaf selenium-containing additive on milk productivity, milk quality and reproductive function of cows. The material for the study were the cows of Bessonovsky type of Holstein black-and-white breed, which was bred on the basis of the breeding farm of the collective farm named after Frunze in the Belgorod area in the Belgorod region. Animals of the 1st control group have been received the main farm ration, cows of the 2nd, 3rd and 4th experimental groups were fed with 100, 150 and 200 g of balanced Selsaf feed complex, respectively in addition to the main ration (per 1 head). During the research, the dynamics of milk productivity, hematological and biochemical parameters of blood in cows, reproduction ability caused by the use of selenium-containing drug Selsaf were analyzed, an economic assessment of the effectiveness of its use has been given. It has been found as a result of the conducted research and taking into account the indicators of selenium content in milk, as well as its great biological value, that the most acceptable dosage is 200 g/head/day of the selenium-containing additive Selsaf, which has been used in the 4th experimental group.
Enzyme-probiotic complex in the rearing of ducks and the effectiveness of its use
Authors:   Federal State Budgetary Educational Institution of Higher Education “Kazan State Academy of Veterinary Medicine named after N. E. Bauman”, Russia, Republic of Tatarstan, Kazan, Yakimov O. A. , Aksakov D. V. ,   Federal State Budgetary Educational Institution of Higher Education “Kazan State Academy of Veterinary Medicine named after N. E. Bauman”, Russia, Republic of Tatarstan, Kazan
Published: June 2022

Modern technologies in poultry farming are aimed at preventing the death of poultry, which brings significant losses to producers. One of the possible ways to improve the physiological status of the bird’s body is the skillful selection of feed, which ultimately will allow for the maximum realization of genetically determined productivity. The purpose of the work was to provide a scientific and practical justification for the effectiveness of the use of an enzyme-probiotic complex in the rearing of ducks of the cross “Cherry Valley” of Beijing breed. The technology of production of meat of broiler ducklings is scientifically and economically justified when using an enzyme-probiotic complex based on the poly-enzyme drug “Universal” and the probiotic drug Actisaf as part of their compound feed. The optimal dose of the introduction of the probiotic Actisaf into the diet of poultry for its further use as part of a complex drug has been determined. It has been experimentally substantiated and proved that the use of the enzyme-probiotic complex in the feed of broiler ducklings makes it possible to increase the nutritional value and usefulness of their feeding, livability, energy and growth rate, normalize morphological and biochemical parameters of blood, the functional state of internal organs, positively affects the digestibility and use of feed nutrients. This allows us to get high-quality products and increase the profitability of its production. The economic efficiency was according to groups such as in the 1st experimental group (the optimal dose of drug Actisaf) it was 32 rubles, in the 2nd experimental group (the recommended dose of the poly-enzyme drug Universal) it was 11,6 rubles and in the 3rd experimental group (enzyme-probiotic complex) it was 56,3 rubles, including based on 1 rub of additional costs – 1,56 rub, 1,59 and 2,03 rub, respectively, for experimental groups. These developments are an important contribution to the problem of improving the theory and practice of fattening broiler ducklings under the conditions of the Republic of Tatarstan.
HASIL PEMERIKSAAN IMUNOKROMATOGRAFI COACTAIL ANTIGEN M.TUBERCULOSIS DAN METODE MOLEKULER PADA SUSPEK HIV
Authors: Fajrunni'mah Rizana
Published: June 2022

Background Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (MTB) infection. Tuberculosis is one of the most common infections in people with HIV/ AIDS. Deaths due to TB in HIV patients occur due to delayed diagnosis. GeneXpert is a breakthrough discovery for TB diagnosis based on molecular examination using the semi quantitative Real Time Polymerase Chain Reaction Assay (RT-PCR) method. An examination has now been developed to detect MTB antigens using the method of rapid immunochromatography in the hope that it can be used as a means of supporting TB diagnosis better than detection of antibodies to MTB.Aim This study aims to compare the results of the TB GeneXpert RTPCR method with the rapid immunochromatography method in suspect HIV.Method This study uses a quantitative design with observational analytic design (cross sectional) with primary and secondary data collection.Result The results of this study found the value of sensitivity, specificity, accuracy, positive predictive value, negative predictive value of the ICT test in a row of 21%, 76%, 40%, 55.8%.Conclusion ICT TB has low sensitivity and sufficient specificity so that it is still not good if used for initial screening to detect pulmonary TB in suspect HIV.
ISOLASI CEMARAN ENTEROBAKTER PADA AIR TANAH GAMBUT DI WILAYAH KUBU RAYA
Authors: Sugito Sugito
Published: June 2022

Background. Peat soil is a type of soil that is formed from the accumulation of half-decayed plant debris. High organic matter content and some minerals with a thickness of approximately 50 cm. The high content of organic matter in peat soils is thought to be one of the factors that play an important role in supporting the process of adaptation of functional microbes. This is because the availability of organic materials needed by functional microbes for growth and metabolism is met.Method. The sampling method used is purposive sampling. Peat water samples were taken in a composite manner from 2 locations with 10 points on the right and 10 points on the creek flow with a distance of about 10 meters at each point with a trench flow length of 100 meters. Samples were taken in the morning, afternoon, and evening from each point then the inspection was carried out at the Polytechnic Laboratory of the Ministry of Health Pontianak.Results. The distribution of Enterobacter in peat soil water samples taken in the morning, afternoon, the evening is still high with based on identification obtained an average percentage of bacteria Klebsiella Pneumonia 100%, Shigella Dysentery 100%, Proteus Vulgaris 80%, Escherichia Coli 70% and Salmonella 70% and Salmonella Typhi 20%. The coagulation test to determine the type or species of a bacterium from the Enterobacter group is carried out with an antisera test.Concl. There is a relationship between morning water samples with afternoon and evening. Based on the Kendall Tau test, the value of the p-value smaller than α (0.05) is 0.009.
Studi Kualitas Kompos Sampah Upacara Agama Hindu Menggunakan Variasi Aktivator Mikroorganisme Lokal (MOL)
Authors: Aryasih I Gusti Ayu Made
Published: June 2022

Background: Local Microorganisms (MOL) contains carbohydrates that are high enough for the needs of microorganisms so that it can be used as an alternative material for an energy source that functions for the growth of microorganism cells to increase the nutrient content, especially in organic carbon to optimize the quality of compost fermentation to be higher. Aims: to determine the best quality of Hindu religious ceremony waste compost with various MOL activators. Methods: this type of research is The Posttest Only Control Group Design. The compost studied was a mixture of 75% Hindu religious ceremonial waste, 15% cow dung, 10% bran, and MOL from rice (P1), dung (P2), tape (P3), and without MOL (K). Results: the whole compost from this study did not have a significant difference in pH, organic carbon, nitrogen, C/N, phosphorus, potassium, moisture content, and electrical conductivity values and there were variations in compost microorganisms at MOL variations (p 0.05). Conclusion: there is no difference in the quality of the best Hindu religious ceremony waste compost with various MOL activators.
GAMBARAN ANGKA LEMPENG TOTAL DAN IDENTIFIKASI Escherichia coli PADA BAKSO AYAM YANG DIJUAL DI DESA SANUR KAUH DENPASAR SELATAN
Authors: Sudarmanto I Gede
Published: June 2022

ABSTRACTIntroduction: Chicken meatballs are a typical Indonesian processed meat food made from a mixture of chicken meat, tapioca flour, and spices. Chicken meatballs are one of the favorite foods of the society, but several studies on meatballs still show the result that meatballs unqualified in health.Aims: The aim of this study was to determine the quality of bacteriology of chicken meatball which are sold in Sanur Kauh Village. The parameters analyze were total plate count and identification of Escherichia coli bacteria. Methods:This research used description study with laboratory examination conducted at Panureksa Utama Laboratory. Total sample that taken in this study were 12 samples of chicken meatball. The sampling technique is using saturated sampling. Results: Based on total plate count examination, it was found from 12 samples chicken meetballs that 3 samples (25%) unqualified and 9 samples (75%) qualified according to SNI No. 01-3818:2014 about Bakso Daging. The results of identification of Escherichia coli bacteria was found that 1 sample chicken meatball (8,3%) unqualified and 11 samples (91.7%) qualified according to Permenkes No. 1096/MENKES/PER/VI/2011.Discusion: Based on the results, it can be conclude was the most of chicken meatballs was qualified in health. The sellers must be attentive about sanitation and personal hygiene during processing of chicken meatballs.Keywords: chicken meatballs, quality of bacteriology, total plate count, Escherichia coli.
PENGARUH PENYULUHAN MEDIA LEAFLET TERHADAP TINGKAT PENGETAHUAN DAN DUKUNGAN SUAMI TENTANG KELUARGA BERENCANA
Authors: S Hartati , Suryani As’ad , Werna Nontji , Wardihan Sinrang , Ahmad Mardiana , Usman Nilawati
Published: June 2022

Pasangan Usia Subur merupakan sasaran dari program KB, dari seluruh pasangan usia subur terdapat sebagian yang memutuskan untuk tidak memanfaatkan program KB yang disebut sebagai unmet need. Tujuan penelitian menganalisis tingkat pengetahuan dan dukungan suami tentang keluarga berencana pada unmet need sebelum dan sesudah perlakuan. Penelitian dilaksanakan di wilayah kerja Puskesmas Tampa Padang Kecamatan Kalukku Kabupaten Mamuju Provinsi Sulawesi Barat. Metode penelitian dengan Quasy Eksperimental (pretest-postest with control group). Teknik pengambilan sampel dengan Simpel Random Sampling berjumlah 48 Pasangan Usia Subur. Hasil penelitian menggunakan uji Wilcoxon menunjukan ada perbedaan signifikan antara pengetahuan suami sebelum dan setelah penyuluhan pada kelompok ceramah dan kelompok eksperimen dengan nilai p-value 0,000. Sedangkan Pada dukungan suami dengan uji Mac Nemar tidak terdapat perbedaan antara dukungan suami sebelum dan setelah penyuluhan dengan nilai p-value=0,063 > (p=0,05) pada kelompok ceramah sedangkan kelompok eksperimen terdapat perbedaan antara dukungan suami sebelum dan setelah penyuluhan dengan p-value=0,000 < (p=0,05). Kesimpulan ada pengaruh penyuluhan media leaflet terhadap tingkat pengetahuan dan dukungan suami tentang keluarga berencana pada unmet need di wilayah kerja Puskesmas Tampa Padang Kecamatan Kalukku Kabupaten Mamuju Provinsi Sulawesi Barat tahun 2020.
Results of protease inhibitor instructions in patients in acute burning disease
Authors: Lynnyk O. M. , Kozynets H. P. , Osadcha O. I.
Published: June 2022

The purpose of the study was to determine the clinical efficiency of proteinase inhibitor usage in patients with burns. Materials and Methods. The results of studies performed in 32 patients with superficial and deep burns were analyzed: 12 patients of the main group, whom were used the proteinase inhibitor drug in the complex treatment, and 20 comparison groups, who were treated according to the standard scheme.  The content of calpains, α-1 proteinase inhibitor (α-1-IP), α-2 macroglobulin (α-2-MG) and tumor necrosis factor α (TNF-α) in patients’ peripheral blood were determined. Results. The decrease in proteolytic activity of blood in patients of the main group was determined as a decrease in calpain levels by 1.16 times (50.51 ± 10.32 μEq/min on the 10th-16th day compared to baseline 58.83 ± 3.62 μEq/min on the 1-4th day after injury), while in the comparison group indicators of calpain content did not tend to decrease. Comparing the TNF-α values ​​of the main group and the comparison group, it was found that the values ​​of the main group were significantly lower 1.15 times on the 5th-9th day (245.33 ± 10.36 pg/ml and 281.2 ± 13, 67 pg/ml) and 1.08 times lower on the 10th-16th day (236.60 ± 8.78 pg/ml and 256.35 ± 15.70 pg/ml). The usage of ulinastatin led to a less pronounced decreasing in proteinase inhibitors levels: α-1-IP (79.31 ± 1.54 μmol/l of the main group compared with 72.1 ± 7.8 μmol/l of the control group on the 5th-9th day after injury and 75.34 ± 5.13 μmol/l of the main group compared with 68.0 ± 4.9 μmol/l of the control group on the 10-16th day after injury), α-2-MG (2.63 ± 0.24 g/l of the main group compared with 2.2 ± 0.4 g/l of the control group on the 10-16th day after injury). Conclusion. The results of the study indicate that the proteinase inhibitor drug included in the standard treatment regimen for acute burns optimizes the proteolytic activity of peripheral blood, promotes the inflammatory response optimal development, inhibits the endothelial dysfunction development.
Resource support of certified quality management systems of dental care
Authors: Krut А. G. , Tolstanov O. K. , Horachuk V. V.
Published: June 2022

Abstract. Standards for quality management systems require support for the system resources: human, infrastructure, process environment, knowledge, competence, awareness, communication, documented information. Objective. To conduct a systematic analysis of resource management in certified quality management systems of dental institutions; suggest ways to improve it. Materials and Methods. Forms №№ 17, 20 of the state statistical reporting, internal documents of municipal non-profit enterprises: "Zhytomyr Regional Dental Medical Association"; Kharkiv Regional Council "Regional Dental Clinic"; "Chernihiv Regional Dental Clinic of the Chernihiv Regional Council" were used (a total of 37 units). Methods: medical and statistical; system approach; content and comparative analysis; graphic. Results. It has been established that the institutions are provided with highly qualified competent medical staff, but there are no dental hygienists among the positions and individuals of specialists, which overloads dentists with simpler preventive procedures. At the same time, preventive measures are important to prevent the development of caries, periodontitis and diseases of the oral mucosa. There is no widespread involvement of employees in freelance organizational structures, monitoring and internal audit of processes and quality management systems. Heads of institutions did not organize the development and implementation of local clinical protocols based on evidence data. Dental care technologies are regulated by industry standards developed in 2004 on the basis of professional consensus. Clinical pathway of the patient, as organizational regulations of dental care, are descriptive textual in nature, the direction of the patient's movement is not traced, as well as the sequence of interaction of structural units - participants in the treatment and diagnostic process. Clinical quality indicators are not implemented in institutions and are not subject to calculations and monitoring. This creates risks for the effectiveness of patient-centered dental care. External and internal interactions of institutions and their structural units are unclear; there is a shortage of medical equipment; modern digital technologies are used to a limited extent for internal and external communications. Conclusion. Opportunities for the implementation of quality management, laid down in the standard, in each dental institution in the real conditions of its operation are not fully used, which requires the attention of heads of institutions in problematic areas.
Aspects of quality control over the organization and examination of temporary disability at the current stage
Authors: Lashkul Z. V. , Chemyrysov V. V. , Kurochka V. L. , Motovitsa N. Ya. , Sizintsova Yu. Yu.
Published: June 2022

Purpose of the study. Coverage of the problem and formation of recommendations for quality control over the organization and conduct of examination of temporary disability at the present stage.

Materials and methods of research. In order to highlight the problems of legal assessment of the quality of the organization and conduct an interim examination at the current level, we analyzed the regulations adopted at the level of the Cabinet of Ministers, the Ministry of Health of Ukraine, identified gaps and recommendations for adopting orders of the Ministry of Health of Ukraine. quality at the level of health care institutions

Conclusions. When implementing quality control measures for the organization and examination of temporary disability at the present stage, special attention should be paid to the development of more detailed and specific legislative documents highlighting the functional responsibilities, rights and responsibilities of health care workers, as well as internal orders governing the examination of temporary disability. disability (ETN) and all components of its activities, including the availability of quarterly and annual reports, analysis of morbidity with temporary disability, indicating specific measures to reduce it, etc. Changes in the regulatory framework of external departmental and interagency control over the implementation of ETN dictate the need to adjust already established organizational forms of control at the level of relevant control structures, as well as strengthening internal departmental control over the organization of ETN in health care facilities. requirements at the present stage.
Determination of pro-inflammatory and humoral factors in gonarthrosis in women with hypertension and overweight
Authors: Fushtey I. M. , Pidlubna A. M.
Published: June 2022

Purpose of the study. The purpose of the work. to study the influence of pro-inflammatory cytokines and neurohumoral factors of adipose tissue on the pathogenesis of HA in women with NM and hypertension to further improve the effectiveness of treatment of this group of patients.

Materials and methods. We examined 198 women with GA and GA in combination with GC and NM aged 40 to 70 years (average - 62.6 ± 1.9 years) with a disease duration of an average of 13.4 ± 3.8 years. In order to analyze the impact of comorbid pathology on the underlying disease, all surveyed women were divided into three groups. The first group (G1) included 59 women with symptoms of HA without concomitant pathology, the second (G2) group - 74 women with HA and GC, and the third (G3) 65 women with HA and GC and NM. All patients underwent standard general clinical examination. In order to study the neurohumoral aspects of the disease, enzyme-linked immunosorbent assay of C-reactive protein, tumor necrosis factor, interleukin-1beta, interleukin 6, interleukin 10 and leptin was performed.

Results. It was found that the combination of excess weight with the course of HA leads to a more significant increase in the production of proinflammatory cytokines compared with patients with HA without concomitant pathology (p <0.05). Direct correlations have been established between weight gain and increased levels of proinflammatory cytokines and adipose tissue neurohumoral factors.

Conclusions. The combination of inflammatory and destructive changes in the joints in HA with weight gain and increased blood pressure, creates conditions for the development of severe immunological disorders in patients and requires pharmacological correction.
SERUM LEVEL OF SOME CYTOKINES IN CHILDREN 6-10 YEARS OLD WITH HIGH FREQUENCY OF ACUTE RESPIRATORY INFECTIONS
Authors: Ovcharenko L. S. , Vertegel A. O. , Redko I. I. , Andrienko T. G. , Samohin I. V. , Kryazhev O. V. , Chakmazova O. M.
Published: June 2022

Objective: improved diagnosis of immune disorders in children aged 6-10 years old, who are often ill od upper respiratory tract infections (URTI), on the basis of these data, further investigation of serum equalities of cytokines, a way of diagnosing with indications in healthy children.

 Materials and methods. There were 60 children of 6 to 10 years of age, from which 2 groups were formed: 1). children who are often ill with URTI (n=30); 2). children, who do not get sick often URTI (n=30).

 Results. among children of 6-10 years of age, as often ill with URTI, the frequency of registration of high indications in place of interleukin-6 blood serum (by 53.3%, p<0.05), TNF (by 63.3%, p <0.05) and low indications for interleukin-10 (by 33.3%, p<0.05), it was established that there was a high probability (odds ratio) of an increase serum interleukin-6, TNF and a decrease in interleukin-10 as a reference value, it is associated with the presence of an increased incidence of URTI in children.

 Conclusion. in children aged 6-10 years, as they often fall ill with URTI, may tend to intensify pro-inflammation of the immune reactions, which still does not ensure a decrease in serious illness on URTI and unsafe side of the development of opportunistic diseases.
PROBLEMS OF ANTIBIOTIC THERAPY IN KOVID-ASSOCIATED HOSPITAL PNEUMONIA
Authors: Savchenko O. A. , Podsevahyna S. L. , Tkachenko A. V. , Myrnyi D. P. , Katsiuba Y. V. , Myrna A. I.
Published: June 2022

Introduction. The advent of the COVID-19 pandemic has posed challenges to healthcare professionals. The most common manifestation of a new variant of coronavirus disease is pneumonia, and therefore, the doctor is faced with the question of the diagnostic value of certain indicators, as well as - the feasibility of prescribing antibacterial therapy.

The purpose of the study was to assess the importance of clinical, imaging, laboratory methods for diagnosing the condition of patients with covid-associated pneumonia, to determine the nuances of the possible appointment of antibacterial therapy.

Current text. The main problem in the diagnosis of covid-associated pneumonia is the need to differentiate between viral lung disease and the development of secondary bacterial pneumonia. Viral pneumonia can be of varying severity, but does not require antibacterial therapy. At the same time, the accession of bacterial flora on the background of viral lung disease, requires the immediate appointment of antibacterial drugs. It should be noted that the available data to date indicate that the accession of bacterial infection to viral lung disease is confirmed in no more than 8-10% of patients, ie most patients with coronavirus do not require antibiotics [1,2, 3]. At the same time, worldwide, antibiotics associated with pneumonia-associated pneumonia are unreasonably common and, according to some studies, the proportion of patients receiving antibacterial therapy ranges from 27% to 84% [1,4,5].

Conclusions. The problem of managing patients with covid-associated pneumonia is due to the fact that, to date, there is no specific criterion that would clearly distinguish viral lung disease from viral-bacterial. Traditionally, data from clinical, laboratory and instrumental research methods are used for the differential diagnosis of viral and bacterial pneumonia. A common approach to antibiotic treatment in many cases is not only unjustified, but also leads to a massive increase in antibiotic resistance with subsequent complications. In each case, the decision must be made individually, taking into account the full range of diagnostic and clinical aspects.