bluuebunny/crossref_metadata_2025 huggingface dataset:
Surgical strategy for intraductal papillary mucinous neoplasms of the pancreas
Authors: Hirono Seiko , Yamaue Hiroki
Published: December 2019

The current treatment strategy for intraductal papillary mucinous neoplasms (IPMNs), based on the international consensus guideline, has been accepted widely. However, reported outcomes after surgical resection for IPMN show that once the tumor progresses to invasive intraductal papillary mucinous carcinoma (IPMC), recurrence is not uncommon. The surgical treatment for IPMN is invasive and sometimes followed by complications. Therefore, the best timing for resection might be at the point when high-grade dysplasia (HGD) is evident. According to previous reports, main duct type IPMN has a high malignant potential and its surgical resection is universally accepted, whereas, the incidence of HGD/invasive IPMC in branch duct and mixed type IPMNs is thought to be lower. In addition to mural nodules and a dilated main pancreatic duct, cytology and measurement of the carcinoembryonic antigen level in the pancreatic juice might be useful to differentiate HGD/invasive IPMC from low-grade dysplasia. The nomogram proposed recently to predict the risk of HGD/invasive IPMC in IPMN patients might help surgeons decide on the best treatment strategy, depending on the patient’s age and general condition. Second resection for high-risk lesions in the remnant pancreas might improve the survival of IPMN patients.
Swell and microstructural characteristics of high-plasticity clay blended with cement
Authors: Abbey S. J. , Eyo E. U. , Ng’ambi S.
Published: December 2019

This study presents the effect of high plasticity on swell potential, swelling pressure and micro-structural characteristics of kaolinite-bentonite mixed clays. Five different mix ratios of kaolinite bentonite mixture of 100:0, 90:10, 75:25, 50:50 and 25:75 in % by weight of dry kaolinite were used. All five synthesised soils were then mixed with 0%, 5% and 8% of cement by weight of dry soil, cured for 28 days and subjected to the Atterberg limit, one-dimensional oedometer and scanning electron microscope test. The inclusion of 5% and 8% cement reduces the plasticity index of the treated soils as the percentage of bentonite increases. The effects on plasticity of treatment with 5% and 8% cement after a 28-day curing period was evaluated, and the results show that reduction in plasticity index resulted in decreased swell potential and swelling pressure of the kaolinite-bentonite mixed clays. The results of microstructural analysis of 5% cement-treated soils show formation of flocculated fabric and cementation of soil particles, and filling with cementitious compounds of the voids of flocculated fabric in the soil. The reduction in swell can be attributed to the resulting compacted and dense mass of treated soils due to cementation of soil particles and cation exchange. The complex swell behaviour of high-plasticity kaolinite-bentonite mix is explained using the one-dimensional oedometer test, by further experimental study and examination of the microstructure of treated soils.
Language in science performance: do good readers perform better?
Authors: Cruz Neri Nadine , Guill Karin , Retelsdorf Jan
Published: December 2019

Science performance is highly affected by students’ reading comprehension. Recently, there has been a growing attention to the role of linguistic features for science performance, but findings are ambivalent, especially when looking into item word count. The aim of this study was to investigate the interaction of students’ reading comprehension and item word count of given science measures on performance, controlling for students’ cognitive abilities, gender, family language, and school track. The sample consisted of N = 2051 German students in grades 10 and 11. Students completed (scientific) literacy measures. We then applied a multilevel logistic regression to investigate the hypothesized interaction effect of reading comprehension and word count on students’ science performance. The results showed a significant interaction of students’ reading comprehension and word count on science performance, controlling for several covariates. Particularly students with high reading comprehension benefit from science items with increasing word count. Our findings empirically support previous research, showing that reading comprehension is crucial for science performance and enhances the interaction between reading comprehension and linguistic features of written text in science subjects. Finally, theoretical and practical implications and limitations of this study are discussed.
Bio-inspired microneedle design for efficient drug/vaccine coating
Authors: Plamadeala Cristina , Gosain Saransh R. , Hischen Florian , Buchroithner Boris , Puthukodan Sujitha , Jacak Jaroslaw , Bocchino Andrea , Whelan Derek , O’Mahony Conor , Baumgartner Werner , Heitz Johannes
Published: December 2019

Biomimetics is the interdisciplinary scientific field focused on the study and imitation of biological systems, with the aim of solving complex technological problems. In this paper, we present a new bio-inspired design for microneedles (MNs) and MN arrays, intended for rapidly coating the MNs with drug/vaccine. The biomimetic approach consists in ornamenting the lateral sides of pyramidal MNs with structures inspired by the external scent efferent systems of some European true bugs, which facilitate a directional liquid transport. To realize these MNs, two-photon polymerization (TPP) technique was used. Liquid coating capabilities of structured and non-structured MNs were compared. Moreover, both in-vivo and ex-vivo skin tests were performed to prove that MNs pierce the skin. We show that the arrays of MNs can be accurately replicated using a micro-moulding technique. We believe this design will be beneficial for the process of drug/vaccine loading onto the needles’ surfaces, by making it more efficient and by reducing the drug/vaccine wastage during MN coating process.
Examining the Treatment Efficacy of PEERS in Japan: Improving Social Skills Among Adolescents with Autism Spectrum Disorder
Authors: Yamada Tomoko , Miura Yui , Oi Manabu , Akatsuka Nozomi , Tanaka Kazumi , Tsukidate Naotake , Yamamoto Tomoka , Okuno Hiroko , Nakanishi Mariko , Taniike Masako , Mohri Ikuko , Laugeson Elizabeth A.
Published: December 2019

This study examines the efficacy of the Japanese version of the Program for the Education and Enrichment of Relational Skills (PEERS), which focuses on improving social functioning through making friends and maintaining good relationships for adolescents with autism spectrum disorder (ASD) without intellectual disabilities. Originally developed in the United States, PEERS is one of the few evidence-based social skills training programs for youth with ASD. The present study shows that with linguistic and cultural modifications, PEERS is effective in improving social functioning for adolescents with ASD in Japan. Positive results were found specifically in the areas of socialization, communication, knowledge of social skills, autistic mannerisms, and behavioral and emotional problems. In addition, most treatment gains were maintained at a 3-month follow-up assessment. These findings suggest that the Japanese version of PEERS is beneficial across multiple socio-emotional and behavioral domains for adolescents with ASD.
Effect of Partial Sick Leave on Sick Leave Duration in Employees with Musculoskeletal Disorders
Authors: Bosman Lisa C. , Twisk Jos W. R. , Geraedts Anna S. , Heymans Martijn W.
Published: December 2019

Objective This study determined if partial sick leave was associated with a shorter duration of sick leave due to musculoskeletal disorders (MSD) based on routinely collected health data in Dutch sick-listed employees. Furthermore, the effect of timing of partial sick leave on sick leave duration was determined. Methods This cohort study consisted of 771 employees with partial sick leave and 198 employees with full-time sick leave who participated in an occupational health check, and had sick leave due to MSD for minimally 4 weeks and were diagnosed by an occupational physician. Multivariable linear regression models were performed to determine the effects of partial sick leave (unadjusted and adjusted for confounders and MSD diagnosis) and Kaplan–Meier curves were presented for visualization of return to work for different timings of starting partial sick leave. Furthermore, linear regression analysis were done in subsets of employees with different minimal durations of sick leave to estimate the effects of timing of partial sick leave. Results Initial results suggest that partial sick leave was associated with longer sick leave duration, also when adjusted for confounders and sick leave diagnosis. Secondary results which accounted for the timing of partial sick leave suggest that partial sick leave had no effect on the duration of sick leave. Conclusion Partial sick leave does not influence MSD sick leave duration in this study when accounting for the timing of partial sick leave.
Water transport and absorption in pharmaceutical tablets – a numerical study
Authors: Vaitukaitis Povilas , Maggiolo Dario , Remmelgas Johan , Abrahmsén-Alami Susanna , Bernin Diana , Siiskonen Maria , Malmqvist Johan , Sasic Srdjan , Sardina Gaetano
Published: December 2019

The quality of a coated pharmaceutical tablet can be strongly affected by the interactions of water droplets with the porous substrate during processes such as coating process. Three different mechanisms co-exist in the coating process: water spreading, absorption and evaporation. Disentangling the fundamental understanding of these phenomena can therefore be crucial for achieving a higher quality of the products (e.g. a longer shelf-life of the tablets) and for controlling the efficiency of the process. This paper aims to investigate the spreading and absorption mechanisms after droplet impingement on a tablet using a Lattice-Boltzmann methodology. Our numerical results (droplet height and spreading, penetration depth and absorbed volume) are in a good agreement with experimental data and numerical simulations available in the literature. In particular, the spreading phase is characterised by the capillary spreading time scale, as confirmed by previous studies. In contrast to previous studies, we find that the absorption process begins at times shorter than the capillary spreading time but with a different power-law in the absorbed volume. We explain this behaviour through a modified Washburn law that takes into account three-dimensional effects. Our data can be used as a benchmark to test novel mathematical models.
Correction to: Optimization along families of periodic and quasiperiodic orbits in dynamical systems with delay
Authors: Ahsan Zaid , Dankowicz Harry , Sieber Jan
Published: December 2019

The article Optimization along families of periodic and quasiperiodic orbits in dynamical systems with delay, written by Zaid Ahsan, Harry Dankowicz, and Jan Sieber, was originally published electronically on 5 November 2019 without open access.
Myxospermous seed-mucilage quantity correlates with environmental gradients indicative of water-deficit stress: Plantago species as a model
Authors: Teixeira António , Iannetta Pietro , Binnie Kirsty , Valentine Tracy A. , Toorop Peter
Published: December 2019

Aims

Myxospermous seed mucilage is multifunctional and is often found in seeds (or achenes) of species occupying arid environments where the trait may influence seed-dispersal and -germination of seeds. The seed mucilage may also enhance soil-water retention, −hydraulic conductivity and -stability. However, the relationship between seed mucilage quantity, seed germination and seedling traits across environmental gradients which determine water-deficit stress has not yet been ascertained.

Methods

Therefore, we characterised and tested the relationship between seed mucilage quantity, water-deficit stress responses of seeds and seedlings of 36 accessions of four different Plantago species (P. albicans L., P. coronopus L., P. lagopus L. and P. anceolata L.). These were gathered from six regions across Europe, which presented environmental gradients (of rainfall and temperature), and varying soil qualities.

Results

Seed mucilage was significantly greater in seeds of accessions experiencing: highest summer temperatures; lowest summer precipitation; soils of the same warm dry regions which had greater capacity to retain water within narrow pore spaces. Under water-deficit stress, seeds with most mucilage exhibited a lower base water potential for germination, suffered least seedling mortality and exhibited the most successful seedling development.

Conclusions

The findings indicate that seed mucilage quantity appeared as an ‘adaptive’ trait and there is a relationship between seed-mucilage quantity, seed germination plus seedling survival and development under environmental conditions of highest water-deficit stress.
Life cycle assessment of California unsweetened almond milk
Authors: Winans Kiara S. , Macadam-Somer Ilan , Kendall Alissa , Geyer Roland , Marvinney Elias
Published: December 2019

Purpose

Plant-based alternatives to dairy milk have grown in popularity over the last decade. Almond milk comprises the largest share of plant-based milk in the US market and, as with so many food products, stakeholders in the supply chain are increasingly interested in understanding the environmental impacts of its production, particularly its carbon footprint and water consumption. This study undertakes a life cycle assessment (LCA) of a California unsweetened almond milk.

Methods

The scope of this LCA includes the production of almond milk in primary packaging at the factory gate. California produces all US almonds, which are grown under irrigated conditions. Spatially resolved modeling of almond cultivation and primary data collection from one almond milk supply chain were used to develop the LCA model. While the environmental indicators of greatest interest are global warming potential (GWP) and freshwater consumption (FWC), additional impact categories from US EPA’s TRACI assessment method are also calculated. Co-products are accounted for using economic allocation, but mass-based allocation and displacement are also tested to understand the effect of co-product allocation choices on results.

Results and discussion

The GWP and FWC of one 48 oz. (1.42 L) bottle of unsweetened almond milk are 0.71 kg CO2e and 175 kg of water. A total of 0.39 kg CO2e (or 55%) of the GWP is attributable to the almond milk, with the remainder attributable to packaging. Almond cultivation alone is responsible for 95% of the FWC (167 kg H2O), because of irrigation water demand. Total primary energy consumption (TPE) is estimated at 14.8 MJ. The 48 oz. (1.42 L) PET bottle containing the almond milk is the single largest contributor to TPE (42%) and GWP (35%). Using recycled PET instead of virgin PET for the bottle considerably reduces all impact indicators except for eutrophication potential.

Conclusions

For the supply chain studied here, packaging choices provide the most immediate opportunities for reducing impacts related to GWP and TPE, but would not result in a significant reduction in FWC because irrigation water for almond cultivation is the dominant consumer. To provide context for interpretation, average US dairy milk appears to have about 4.5 times the GWP and 1.8 times the FWC of the studied almond milk on a volumetric basis.
Voltage-gated Sodium Channels and Blockers: An Overview and Where Will They Go?
Authors: Li Zhi-mei , Chen Li-xia , Li Hua
Published: December 2019

Voltage-gated sodium (Nav) channels are critical players in the generation and propagation of action potentials by triggering membrane depolarization. Mutations in Nav channels are associated with a variety of channelopathies, which makes them relevant targets for pharmaceutical intervention. So far, the cryoelectron microscopic structure of the human Nav1.2, Nav1.4, and Nav1.7 has been reported, which sheds light on the molecular basis of functional mechanism of Nav channels and provides a path toward structure-based drug discovery. In this review, we focus on the recent advances in the structure, molecular mechanism and modulation of Nav channels, and state updated sodium channel blockers for the treatment of pathophysiology disorders and briefly discuss where the blockers may be developed in the future.
Hospital staff participation in a national hip fracture audit: facilitators and barriers
Authors: Voeten Stijn C. , van Bodegom-Vos Leti , Hegeman J. H. , Wouters Michel W.J.M. , Krijnen Pieta , Schipper Inger B.
Published: December 2019

Summary

To ensure meaningful results in a clinical audit, as many hospitals as possible should participate. To optimise participation, the data collection process should either be performed by additional staff or be automated. Active participation may be promoted by offering relevant external parties insight into the actual quality of care.

Purpose

The aim of the study was to identify which facilitators and barriers experienced by hospital staff are associated with participation in the ongoing nationwide multidisciplinary Dutch Hip Fracture Audit (DHFA).

Methods

A survey including questions about the respondents’ characteristics, hospital level of participation and factors of influence on DHFA participation was sent to hip fracture surgeons. The factors were based on results of semi-structured interviews held with hospital staff involved in hip fracture care. Univariable and multivariable logistic regression analyses were used to establish which respondent characteristics and factors were associated with participation and active participation (≥ 80% of patients registered) in the DHFA. Factors significantly increasing the (active) participation in the DHFA were classified as facilitators, and factors significantly decreasing the (active) participation in the DHFA as barriers.

Results

One hundred nine surgeons filled out the questionnaire. The factors most agreed on were availability of staffing capacity for data collection and automated data import. A lower intention to participate was associated with being an academic surgeon (odds ratio, 0.15; 95% confidence interval, 0.04–0.52) and an orthopaedic surgeon (odds ratio, 0.30; 95% confidence interval, 0.10–0.90). Data sharing with relevant external parties was associated with active participation (odds ratio, 3.19; 95% confidence interval, 1.14–8.95).

Conclusions

To improve participation in a nationwide clinical audit, it seems that the data collection should either be performed by additional staff or be automated. Active participation is facilitated if audit data is made available to other parties, such as insurers, healthcare authorities or policymakers.
Optimization of rhizogenesis for in vitro shoot culture of Pinus massoniana Lamb.
Authors: Wang Yin , Yao Ruiling
Published: December 2019

The rooting capacity of Pinusmassoniana is poor, especially for mature trees, and has prevented the development of clonal forestry for P.massoniana. In this study, we varied explant types, subculture times and exogenous hormones for plantlet regeneration and assessed shoots for rooting rate and root number for P.massoniana. Following five repetitive grafts, new shoots from grafts used as explant sources were rejuvenated as observed from juvenile shoot morphology and anatomy, leading to greatly enhanced plant regeneration in comparison to that of mature materials from 26-year-old P.massoniana trees. The rooting capacity of subcultured shoots increased with successive subcultures, reaching a peak at 20 subcultures with 35–40 days per subculture. However, rooting performance was significantly reduced after 30 subcultures. The addition of naphthaleneacetic acid (NAA) plus indoleacetic acid in the medium improved the root number, but the combination of exogenous NAA with paclobutrazol (PBZ) increased rooting rate and root number. We thus greatly improved the rooting capacity of mature P.massoniana trees by optimizing explant types (rejuvenated), subculture times (20 subcultures, 35–40 days per subculture) and addition of NAA + PBZ to the rooting medium. The conditions can be used for efficient plantlet regeneration of P.massoniana.
Air pollution in European countries and life expectancy—modelling with the use of neural network
Authors: Kolasa-Więcek Alicja , Suszanowicz Dariusz
Published: December 2019

The present paper discusses a novel methodology based on neural network to determine air pollutants’ correlation with life expectancy in European countries. The models were developed using historical data from the period 1992–2016, for a set of 20 European countries. The subject of the analysis included the input variables of the following air pollutants: sulphur oxides, nitrogen oxides, carbon monoxide, particulate matters, polycyclic aromatic hydrocarbons and non-methane volatile organic compounds. Our main findings indicate that all the variables significantly affect life expectancy. Sensitivity of constructed neural networks to pollutants proved to be particularly important in the case of changes in the value of particulate matters, sulphur oxides and non-methane volatile organic compounds. The most frequent association was found for fine particle. Modelled courses of changes in the variable under study coincide with the actual data, which confirms that the proposed models generalize acquired knowledge well.
Bone Health in Men with Prostate Cancer: Review Article
Authors: A M El Badri Salma , Salawu Abdulazeez , Brown Janet E
Published: December 2019

Purpose of Review

The improvement in prostate cancer survival over time, even in those with advanced disease, has led to an increasing recognition of the impact of prostate cancer and its treatment on bone health. Cancer treatment–induced bone loss (CTIBL) is a well-recognized entity but greater awareness of the risks associated with CTIBL and its treatment is required.

Recent Findings

The principal culprit in causing CTIBL is hormonal ablation induced by prostate cancer treatment, including several new agents which have been developed in recent years which significantly improve survival, but may cause CTIBL. This review discusses the impact of prostate cancer and its treatment on bone health, including published evidence on the underlying pathophysiology, assessment of bone health, and strategies for prevention and treatment.

It is important to recognize the potential cumulative impact of systemic prostate cancer treatments on bone health.
Potential of Recent Ambient Ionization Techniques for Future Food Contaminant Analysis Using (Trans)Portable Mass Spectrometry
Authors: Blokland Marco H. , Gerssen Arjen , Zoontjes Paul W. , Pawliszyn Janusz , Nielen Michel W.F.
Published: December 2019

In food analysis, a trend towards on-site testing of quality and safety parameters is emerging. So far, on-site testing has been mainly explored by miniaturized optical spectroscopy and ligand-binding assay approaches such as lateral flow immunoassays and biosensors. However, for the analysis of multiple parameters at regulatory levels, mass spectrometry (MS) is the method of choice in food testing laboratories. Thanks to recent developments in ambient ionization and upcoming miniaturization of mass analyzers, (trans)portable mass spectrometry may be added to the toolkit for on-site testing and eventually compete with multiplex immunoassays in mixture analysis. In this study, we preliminary evaluated a selection of recent ambient ionization techniques for their potential in simplified testing of selected food contaminants such as pesticides, veterinary drugs, and natural toxins, aiming for a minimum in sample preparation while maintaining acceptable sensitivity and robustness. Matrix-assisted inlet ionization (MAI), handheld desorption atmospheric pressure chemical ionization (DAPCI), transmission-mode direct analysis in real time (TM-DART), and coated blade spray (CBS) were coupled to both benchtop Orbitrap and compact quadrupole single-stage mass analyzers, while CBS was also briefly studied on a benchtop triple-quadrupole MS. From the results, it can be concluded that for solid and liquid sample transmission configurations provide the highest sensitivity while upon addition of a stationary phase, such as in CBS, even low μg/L levels in urine samples can be achieved provided the additional selectivity of tandem mass spectrometry is exploited.
A case of poorly differentiated adenocarcinoma with lymphoid stroma originated in the ascending colon diagnosed as lymphoepithelioma-like carcinoma
Authors: Kai Kengo , Hidaka Hideki , Nakamura Takeshi , Ueda Yuji , Marutsuka Kosuke , Ikeda Takuto , Nanashima Atsushi
Published: December 2019

An 86-year-old woman’s stool sample was positive for blood. Computed tomography (CT) showed wall thickening of the ascending colon at the hepatic flexure. Colonoscopy showed near-complete obturation by colon cancer. Since she was asymptomatic, elective surgery was planned. Laparoscopic right hemicolectomy was performed. Histopathological examination showed poorly differentiated carcinoma cells proliferating in a solid pattern with marked lymphocyte infiltration. The diagnosis was lymphoepithelioma-like carcinoma (LELC) associated with Epstein-Barr virus (EBV) infection; however, EBV-encoded small RNA–in situ hybridization was negative. Microsatellite instability was not assessed. The postoperative course was uneventful and she was discharged on the 15th postoperative day. She remains recurrence-free at 2 years after surgery. Past reports note that colorectal carcinomas with dense lymphoid stroma may be related to LELC or medullary carcinoma (MC). Gastrointestinal LELC is rare, with some reports on LELC of the esophagus and stomach. Reports on LELC of the large intestine are very rare. MC of the large intestine is relatively new concept, firstly described in the WHO Classification of Tumours of the Digestive System 3rd Edition in 2000. We herein present a case of lymphoepithelioma-like carcinoma of the ascending colon and relevant case reports about LELC and MC of the large intestine.
Mycotoxins in blood and urine of Swedish adolescents—possible associations to food intake and other background characteristics
Authors: Warensjö Lemming Eva , Montano Montes Andrea , Schmidt Jessica , Cramer Benedikt , Humpf Hans-Ulrich , Moraeus Lotta , Olsen Monica
Published: December 2019

The exposure to mycotoxins of Swedish adolescents is currently unknown. The aim of the present study was to investigate the exposure to mycotoxins and their association with food intake, and background characteristics in adolescents of a national dietary survey. About 3000 school students (1000 from the 5th, 8th and 11th school years) were recruited for the survey. The participants completed Web-based questionnaires on food propensity, sociodemography and health, and a Web-based dietary recall. Spot urine and blood samples were collected from 1105 of the participants for mycotoxin biomarker analysis. Mycotoxins were analysed with multibiomarker methods in urine (HPLC-MS/MS) and serum (HPLC-MS/MS). Of the 35 different analytes in urine, the frequency of positive samples were the following: deoxynivalenol (DON, 4.8%), DON-15-β-D-O-glucuronide (DON-15GlcA, 9.1%), dihydro-citrinone (DH-CIT, 0.5%), HT-2-glucuronide (HT-2-3-GlcA, 0.1%) and ochratoxin A (OTA, 0.1%). Of the 27 different analytes in serum, OTA was detected in all samples, while 2’R-ochratoxin A (2’R-OTA) was found in 8.3% and enniatin B (EnB) in 99.2% of the samples. Exposure assessment calculations were performed on OTA from the serum concentration and on DON equivalents (DON eqv) from the urine concentration. All probable daily intake (PDI) estimates were below tolerable daily intakes, except for 1.6% of the participants for DON. The maximum PDI was 4.3 μg DON eqv/kg body weight and day. Consumption of cereal grain commodities was associated with levels of DON, EnB or OTA in biofluids. Serum OTA was also associated with intakes of raisins and coffee. Furthermore, coffee consumption correlated well with 2’R-OTA concentration in serum. In conclusion, exposure to mycotoxins in Swedish adolescents is common, but fortunately, high exposure was rare.
Numerical investigation of a new structural configuration of a concrete barrier wall under the effect of blast loads
Authors: Taha Ahmed K. , Gao Zhengguo , Huang Dahai , Zahran M. S.
Published: December 2019

In this study, a non-linear three-dimensional hydrocode numerical simulation was carried out using AUTODYN-3D, which is an extensive code dealing with explosion problems. A high explosive material (comp-B) is blasted against several concrete wall barriers. The model was first validated using referenced experimental tests and has shown good results. Several numerical models were carried out to study the effect of changing the shape of wall barrier from flat to convex curve and concave curve, and also investigated the effect of changing the angle of curvature. The results showed that changing the shape of a wall barrier from flat to convex curve has the best performance in mitigating the effect of blast waves. It is also concluded that convex walls with 60° angle of curvature have the best performance compared to other barrier walls.
Tribology of Ti6Al4V: A review
Authors: Philip Jibin T , Mathew Jose , Kuriachen Basil
Published: December 2019

The deleterious innate attribute of Ti6Al4V, the workhorse material among the alloy series of titanium is its incompetent tribo-behavior. Infinite surface modification techniques, viz., the accretion of adherent appendage layers, diffusion hardening, infusion of residual stresses, microstructural evolution, and phase transformations were attempted to enhance the wear resistance of the alloy. The need lies to establish a bridge between the indigenous material properties and the tribo-characteristics of Ti6Al4V so that the enforced improvement techniques can raise the barriers of its applicability. A critical review of the microstructural transitions, mechanisms governing tribo-behavior and the parametric conditions leading to material removal at dry sliding conditions of Ti6Al4V, falls under the scope of this manuscript. Hence, the prime focus of the approach is to impart a clear-cut perception of the minute variations in mechanical, metallurgical, and tribological characteristics of the alloy at interactive instances with distinct counter-body surfaces.
Investigation into Effects of System Design on Metro Drivers’ Safety-Related Performance: An Eye-Tracking Study
Authors: Rjabovs Aleksandrs , Palacin Roberto
Published: December 2019

This paper explores performance shaping factors associated with holistic design aspects of metro systems affecting driver’s behaviour based on a case study using eye-tracking techniques. Train driving is a highly visual task where the physical environment provides key visual instructions. Eye–mind theories suggest that eye movements closely follow cognitive processes when it comes to interaction with the visual world. The data for this study have been collected in a representative urban rail system serving a metropolitan area with circa 1.2 million inhabitants during 20 in-service trials. Participating drivers were asked to wear an eye-tracker while driving a train as they would normally do. The study focuses on four areas of interest at four consecutive stations. The stations have similar characteristics but differ in terms of certain design elements which are mirrors, platforms, stopping position markers and positions of a running signal. Previous studies have demonstrated the importance of these elements to metro drivers. The paper assesses the usability of the system design elements through analysis of gaze fixations. Results suggest the importance of the positions of a mirror and a signal in relation to the cab, as well as the distance between a stopping point and a signal. Such factors as openness of stations, passenger loadings and informativeness of certain elements also demonstrated influence on drivers’ performance. It was also found that drivers sometimes do not check a signal before departing a station, which is a significant concern. The paper discusses factors potentially propagating such behaviour.
Aristotle and the Management Consultants: Shooting for Ethical Practice
Authors: Shaw David
Published: December 2019

The academic literature on management consulting raises many questions about the ethics of management consulting. The uncertain, emergent, and often socially constructed nature of management consultancy knowledge limits the scope both for regulating the industry in the manner of the established professions, and for evaluating management consultants’ work objectively. The character of management consultants is therefore a central issue in how far clients and other stakeholders can trust them. This paper considers three questions, using Aristotle’sNicomachean Ethicsas a guide. These are, first, ‘What is the function of a management consultant?’, second, ‘How should a management consultant act in order to be a good management consultant?’, and third, ‘Where does the boundary lie between the ethical responsibilities of the management consultant and those of the client and other stakeholders?’ Aristotelian virtue ethics are valuable in answering these questions. Their focus on character is well suited to the distinct ethical problems of management consulting. Aristotle’s overarching concern with human flourishing, and an ethically balanced approach towards benefiting from the good things to which a virtuous person may aspire, has more promise as an influence on consultants’ behaviour than the lists of prohibitions that typify codes of ethical practice in the industry. Aristotle’s call for leaders to habituate their people to ethical behaviour should be heard by the leaders of management consultancy firms. In accordance with Aristotle’s philosophy, this paper proposes a positive target at which management consultants can aim in shooting for ethical practice.
On special extrema of polynomials with applications to Diophantine problems
Authors: Hajdu Lajos
Published: December 2019

We prove that apart from explicitly given cases, described in terms of Dickson polynomials, a polynomial$$f\in \mathbb {Q}[x]$$f∈Q[x]can have at most one shift$$f(x)-\lambda $$f(x)-λ$$(\lambda \in \mathbb {C})$$(λ∈C)of the form$$u(g(x))^q(h(x))^k$$u(g(x))q(h(x))kwith$$u\in \mathbb {C}$$u∈C,$$g,h\in \mathbb {C}[x]$$g,h∈C[x]and either$$\deg (g)=2$$deg(g)=2,kis even,$$q=k/2$$q=k/2or$$\deg (g)\le 1$$deg(g)≤1,$$k\ge 2$$k≥2,$$q\ge 1$$q≥1. This is shown by handling the case of two possible shifts, which was an open issue. As an application, we give a precise statement yielding a description of polynomialsfhaving infinitely many shifted power (S-integral) values, and a complete description of superelliptic equations having infinitely manyS-integral solutions when the polynomial involved is composite. In the case where there are finitely many solutions, our results yield effective bounds for them. Finally, as further applications, we give effective results for polynomial values in the solutions of Pell equations and in non-degenerate binary recurrence sequences.
Postpartum Female Sexual Function: Risk Factors for Postpartum Sexual Dysfunction
Authors: Gutzeit Ola , Levy Gali , Lowenstein Lior
Published: December 2019

Introduction

Women's sexual health is a vital and important part of life at any age. In particular, pregnancy and childbirth bring biological, psychological, and social changes which may influence sexual health. It has been shown that sexual function declines during pregnancy and does not return to its baseline levels during the postpartum period. Despite the complexity and significance of this subject, health providers often neglect sexual aspects during pregnancy and postpartum.

Aim

We believe that clarifying the risk factors will help open conversations and improvements in sexual function.

Methods

In this review, we focus on how postpartum sexual function is affected by mode of delivery, perineal trauma during delivery, episiotomy, and lactation.

Concclusions

We conclude that the mode of delivery has no significant effect on short- and long-term postpartum sexual function. On the other hand, 3rd and 4th degree tears are strongly associated with postpartum sexual dysfunction. We found that episiotomy does not adversely affect sexual function, and lactation has a slightly negative effect. We believe that shedding light on this topic will lead to a better understanding for pregnant and postpartum women and the obstetrician. Further studies may elucidate more useful treatment approaches.
Female Sexual Orgasmic Dysfunction and Genital Sensation Deficiency
Authors: Gruenwald Ilan , Lauterbach Roy , Gartman Irena , Aharoni Saar , Lowenstein Lior
Published: December 2019

Introduction

Most studies on female sexual dysfunction (FSD), and female sexual orgasmic disorder (FSOD) in particular, have qualitatively examined cultural and educational factors; only few have quantitatively examined physiological factors.

Aim

The aim of this study was to compare quantitative sensory testing (QST) between women for whom FSOD was their primary complaint and other women with FSD.

Methods

In this retrospective study of women who visited a sexual dysfunction clinic, the study group comprised women for whom FSOD was their primary complaint, and the control group comprised other women with FSD. Sexual dysfunction was assessed by the Female Sexual Function Index (FSFI). QST was performed with a thermal and vibration Genito-Sensory Analyzer (GSA; Medoc Ltd, Israel) aimed at the clitoral and vaginal areas.

Main Outcome Measure

The main outcome was clitoral and vibratory sensory thresholds in accordance with the presence of FSOD.

Results

The study group comprised 89 (45%) women, with a mean age of 37.6 ± 1.9 years; and the control group comprised 110 (55%) women, with a mean age of 37.5 ± 11.3 years. Both mean FSFI-FSOD and total FSFI scores were significantly lower in the study group than in the control group (0.97 ± 0.94 vs 1.91 ± 1.3, P < 0.001) and (11.9 ± 3.2 vs 15.6 ± 3.6, P < 0.001), respectively. Mean clitoral vibratory sensory thresholds were higher in the study group than in the control group: 2.02 confidence interval (CI) 1.12–2.64 vs 1.55 CI 1.12–2.41, P < 0.001. No statistically significant difference was found between the groups in vaginal vibratory thresholds: 3.7 CI 2.6–6.6 vs 3.4 CI 1.9–5.4, P = 0.14.

Clinical Implications

The findings support the role of the clitoris in obtaining sexual orgasm, thus inferring a possible physiologic cause of FSOD in otherwise healthy women, beyond established psychological causes.

Strength & Limitations

Assessments using an objective quantitative measure (QST) and a subjective tool (FSFI) in both the FSOD and control groups are strengths of this study. The retrospective design is a limitation.

Conclusion

QST showed a direct correlation between vibratory clitoral stimulation and FSOD; Compared with the control group, women with FSOD are relatively insensitive to clitoral stimulation, but not to vaginal stimulation.
Pleading Guilty: A Voluntary or Coerced Decision?
Authors: Leclerc Chloé , Euvrard Elsa
Published: December 2019

The empirical literature on plea decisions shows that rational motives and coercion may coexist, but there is uncertainty with regard to whether accused feel that their decision is voluntary or made under considerable pressure. However, in most jurisdictions, the legitimacy of the plea bargaining process rests on the Court’s obligation to ensure that the guilty plea is entered voluntarily and knowingly. This study proposes to understand how the accused interpret the rational or coercive elements of their decision-making process and the extent to which their decision to plead guilty is voluntary. Based on semi-structured interviews with twenty convicted individuals, we describe the different decision-making processes, from free and informed decisions to forced decisions to plead guilty while innocent.
Western Sahara as a Hybrid of a Parastate and a State-in-Exile: (Extra)territoriality and the Small Print of Sovereignty in a Context of Frozen Conflict
Authors: Fernández-Molina Irene , Ojeda-García Raquel
Published: December 2019

This article argues that the “declarative” parastate of the Sahrawi Arab Democratic Republic (SADR) claiming sovereignty over Western Sahara is better understood as a hybrid between a parastate and a state-in-exile. It relies more on external, “international legal sovereignty,” than on internal, “Westphalian” and “domestic” sovereignty. While its Algerian operational base in the Tindouf refugee camps makes it work as a primarily extraterritorial state-in-exile de facto, the SADR maintains control over one quarter of Western Sahara’s territory proper allowing it to at least partially meet the requirements for declarative statehood de jure. Many case-specific nuances surround the internal sovereignty of the SADR in relation to criteria for statehood: territory, population, and government. However, examining this case in a comparative light reveals similarities with other (secessionist) parastates. The SADR exists within the context of a frozen conflict, where the stalemate has been reinforced by an ineffective internationally brokered peace settlement and the indefinite presence of international peacekeeping forces. Global powers have played a major role in prolonging the conflict’s status quo while the specific resilience of the SADR as a parastate has been ensured by support from Algeria as an external sponsor. The path to sovereignty appears to be blocked in every possible way.
Identification of mixed and successive blood meals of mosquitoes using MALDI-TOF MS protein profiling
Authors: Tandina Fatalmoudou , Niare Sirama , Almeras Lionel , Davoust Bernard , Doumbo Ogobara K , Raoult Didier , Parola Philippe , Laroche Maureen
Published: December 2019

Background

The accurate and rapid identification of mosquito blood meals is critical to study the interactions between vectors and vertebrate hosts and, subsequently, to develop vector control strategies. Recently, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) profiling has been shown to be a reliable and effective tool for identifying single blood meals from mosquitoes.

Methods

In this study, we developed MALDI-TOF MS profiling protocols to identify Anopheles gambiae Giles, Anopheles coluzzii and Aedes albopictus mosquitoes’ mixed blood meals and the last of successive blood meals. The mosquitoes were either successively artificially fed with distinct host bloods or engorged with mixed bloods from distinct vertebrate hosts, such as humans, sheep and dogs.

Results

Blind test analyses revealed a correct identification of mixed blood meals from mosquitoes using MALDI-TOF MS profiling. The 353 MS spectra from mixed blood meals were identified using log score values >1.8. All MS spectra (n = 244) obtained from mosquitoes' successive blood meals were reproducible and specific to the last blood meal, suggesting that the previous blood meals do not have an impact on the identification of the last one.

Conclusion

MALDI-TOF MS profiling approach appears to be an effective and robust technique to identify the last and mixed blood meals during medical entomological surveys.
Bioinformatic analysis of eosinophil activity and its implications for model and target species
Authors: Jenvey C.J. , Alenizi D. , Almasi F. , Cairns C. , Holmes A. , Sloan S. , Stear M.J.
Published: December 2019

Eosinophils are important immune cells that have been implicated in resistance to gastrointestinal nematode (GIN) infections in both naturally and experimentally infected sheep. Proteins of particular importance appear to be IgA-Fc alpha receptor (FcαRI), C-C chemokine receptor type 3 (CCR3), proteoglycan 3 (PRG3, major basic protein 2) and EPX (eosinophil peroxidase). We used known human nucleotide sequences to search the ruminant genomes, followed by translation to protein and sequence alignments to visualize differences between sequences and species. Where a sequence was retrieved for cow, but not for sheep and goat, this was used additionally as a reference sequence. In this review, we show that eosinophil function varies among host species. Consequently, investigations into the mechanisms of ruminant immune responses to GIN should be conducted using the natural host. Specifically, we address differences in protein sequence and structure for eosinophil proteins.
Course and symptom and functional correlates of passivity symptoms in schizophrenia: an 18-year multi-follow-up longitudinal study
Authors: Herbener Ellen S. , Harrow Martin
Published: December 2019

Background

Change in the experience of oneself may lay the groundwork for the development of additional hallucinations and delusions in individuals with schizophrenia. However, to date, the course and symptom and functioning correlates of passivity symptoms (cf. thought insertion, thought withdrawal) have not been measured consistently over long periods of time. Information on the course and correlates of passivity symptoms is essential for developing models of their contribution to schizophrenic illness.

Method

Eighty-two individuals diagnosed with schizophrenia or schizoaffective disorder were recruited at an index hospitalization and reassessed at three or more follow-ups over the following 18 years.

Results

The results indicate that a small group of participants report passivity symptoms at all follow-ups, many reported passivity symptoms at some follow-ups, and the majority of individuals never reported passivity symptoms. The prevalence of passivity symptoms was similar to that for delusions of reference and persecutory delusions. Notably, when individuals did experience passivity symptoms, they also had a greater number of additional psychotic symptoms than individuals without passivity symptoms. Further, the presence of passivity symptoms was associated with work impairment at some assessments.

Conclusions

Passivity symptoms present episodically, at a similar rate as delusions of reference and persecutory delusions, and when present, they are associated with having a higher number of additional psychotic symptoms, as well as having some impact on work functioning. These results suggest that passivity symptoms may increase vulnerability to additional psychotic symptoms and greater work impairment.
CAPITAL IN A FRONTIER ECONOMY: PORTUGAL, 1230–1500
Authors: Henriques António
Published: December 2019

In this paper we show that Portugal benefitted from comparatively low-interest rates from the 13thcentury onwards, well before the generalised drop in interest rates in Europe. Contrary to the thesis that frontier economies struggle with high-interest rates and scarcity of capital, we find that the country's low and stable interest rates can be explained by its wide availability of land, combined with monetary stability and a favourable institutional network. These conclusions are built upon an entirely new dataset of interest rates and returns on capital for Portugal in the period 1230–1500.
When a small thin two-dimensional body enters a viscous wall layer
Authors: PALMER R. A. , SMITH F. T.
Published: December 2019

If a body enters a viscous-inviscid fluid layer near a wall, then significant effects can be felt from the presence of incident vorticity, viscous forces and nonlinear forces. The focus here is on the response in the outer edge of such a wall layer. Nonlinear two-dimensional unsteady behaviour is examined through modelling, computation and analysis applied for a thin body travelling streamwise upstream or downstream or staying still relative to the wall. The wall layer with its balance between inviscid and viscous effects interacts freely with the body movement, causing relatively high magnitudes of pressure on top of the body and nonlinear responses in the gap between the body and the wall. The study finds explicit solutions for the motion of the body, separation of the flow arising near the wall and possible instabilities occurring over the length scale of any short body.