bluuebunny/crossref_metadata_2025 huggingface dataset:
Variants of uncertain significance in the genetic diagnosis of heterozygous familial hypercholesterolemia
Authors: Bakaleiko V. V. , Usova E. I. , Reutova O. V. , Krivosheina M. I. , Kostareva A. A. , Alieva A. S.
Published: February 2025

Background. Studying the genetic profile of patients with familial hypercholesterolemia (FH) and their phenotypic characteristics may contribute to a better understanding of the pathogenesis of the disease.Objective. Evaluation of the genetic profile of patients with severe FH phenotype and study of the phenotype of patients with variants of uncertain significance.Design and methods. The study included patients over 18 years of age with ≥ 7 points on the Dutch Lipid Clinical Network Criteria (DLCN) score from the register of the Centre for Atherosclerosis and Lipid Metabolism Disorders of the Almazov National Medical Research Centre. Clinical and anamnestic data were collected, and molecular genetic testing was performed to identify variants in candidate genes responsible for the development of FH.Results. Of 127 patients (mean age 45,2 ± 12,8 years, 61,6 % women), molecular genetic analysis identified a positive diagnosis of FH in 61,4 % with a predominant presence of pathogenic variants in the LDLR gene (90,6 %) and the most frequent type II c.1202T>A p.Leu401His. Among patients with variants of uncertain significance (18,1 %) tendon xanthomas and lipoid arc of the cornea were detected in 6,7 % and 20,0 %, respectively. The mean LDL–C level before treatment was 7,7 ± 1,7 mmol/L. Variants of uncertain significance were verified mainly in low-density lipoprotein cholesterol (35,9 %) and APOB (28,2 %) genes. Three patients from the study sample are carriers of variants in two FH genes: c.*653G>A in LDLR with c.11788+16C>T in APOB; c.1465T>A in LDLR with c.*25C>T in APOE; c.817+6C>T in LDLR with c.2068–4T>A in APOB.Conclusions. The genetic profile of patients with FH is represented by various mutation variants in a number of known genes, the presence of variants of uncertain significance in LDLR and APOB genes indicates the complex genetic nature of the disease, indicating the need for further study of their role.
The disease-modifying therapy in idiopathic pulmonary arterial hypertension: clinical case of calcium channel blocker therapy in long-term vasoresponder
Authors: Korobchenko E. M. , Goncharova N. S. , Lapshin K. B. , Berezina A. V. , Zlobina I. S. , Ryzhkov A. V. , Moiseeva Olga M.
Published: February 2025

Rare vasoreactive test (VRT) performance limits the effective and cheap calcium channel blocker (CCB) therapy in potential long-term vasoresponders patients with idiopathic pulmonary arterial hypertension (PAH). Long-term vasoresponders exhibit the unique (5–7 %) idiopathic PAH population with the highest survival. We presented the clinical case of a young idiopathic PAH with positive VRT and a significant advantage of CCB therapy over PAH-specific therapy. Pulmonary artery pressure and exercise tolerance normalization, complete reverse right heart remodeling were achieved on CCB therapy. Our case emphasized the importance of careful identification of VRT positive idiopathic PAH patients and the meticulous follow-up during CCB treatment.
1D simulation of the impact of direct water injection on a small SI engine performance and emissions
Authors: Kuchmacz Konrad , Noga Marcin
Published: February 2025

The paper contain results of 1D simualtion of the direct water injection for the four stroke single cylinder gasoline engine and shows comparison between cycles with and without water addition.Various water injection timing, as well as water to fuel ratios were considered, including injection during compression stroke and just after finishing the combustion. Results show that direct water injection in internal combustion engines has a minimal effect on overall performance parameters but improves emission levels, particularly reducing NOx emissions. Injection at 100 deg bTDC consistently shows the greatest reduction in NOx emissions across scenarios. However, late water injection during combustion increases HC emissions.
Professores de Educação Física com práticas inovadoras
Authors: Pires Kelly Ferreira , Lazzarotti Filho Ari
Published: February 2025

Constitui a principal finalidade desta pesquisa identificar professores de Educação Física que consideram sua prática predominantemente inovadora no Ensino Básico de Goiânia. Além disso, buscou-se verificar quais desses professores estão dotados de uma abordagem pedagógica considerada inovadora tal qual descrita na literatura especializada. Para cumprir esses propósitos, empregou-se uma metodologia de pesquisa qualitativa, composta por duas etapas: (i) a aplicação de questionários aos professores de Educação Física no Ensino Básico em Goiânia; (ii) a realização de entrevistas semiestruturadas com nove desses profissionais. Constatou-se que oito dos professores entrevistados adotam práticas pedagógicas consideradas inovadoras, que podem ocorrer de maneira separada ou então combinada.
An improved YOLOv5-based method for robotic vision detection of grain caking in silos
Authors: Cao Yi , Zhao Yao , Wu Xiang , Tang Mingqi , Gu Chao
Published: February 2025

Detecting and cleaning grain caking on the inner walls of silos is an important task to ensure food safety in storage facilities. However, in response to challenges such as insufficient lighting conditions, small and diverse forms of grain caking, this paper proposes the development and evaluation of a convolutional neural network model for robot vision detection of grain caking. The following improvements to the visual detection algorithm based on YOLOv5 are proposed in this article. Firstly, the Convolutional Block Attention Module (CBAM) and the improved Total Cross Union (CIoU) loss function are introduced to enhance the detection accuracy of grain caking. Secondly, by adding the Retinex Net algorithm with dark light enhancement, the recognition and detection performance under low light conditions can be improved. The improved YOLOv5 algorithm was trained and validated on a custom grain caking dataset. Comparative experiments show that compared with existing detection architectures, the improved algorithm has improved the average accuracy of grain caking detection by 1.8 % to 3.8 %. Finally, the improved algorithm proposed in this article was deployed on a wall climbing robot based on negative pressure adsorption, achieving real-time detection and automatic cleaning of grain caking.
ANÁLISE DAS NECESSIDADES INFORMACIONAIS DO PEQUENO E MÉDIO VAREJISTA BRASILEIRO
Authors: Ardigo Julibio David , Dias Julio da Silva , Rocha Vinicius Amaro Pinto da
Published: February 2025

O pequeno e médio varejista enfrenta desafios em estruturar seus dados e informações, ainda que as estas sejam consideradas como cruciais na economia atual. O objetivo deste trabalho é identificar requisitos informacionais, internos e externos, que auxiliem na operação e gestão desse tipo de negócio. Para alcançar tal objetivo, foi feito o levantamento e análise de artigos científicos que abordam a demanda informacional desse tipo de organização, em busca de informações relevantes ao tema da pesquisa. Assim, a metodologia utilizada é de abordagem qualitativa, de objetivo descritivo e de procedimento bibliográfico. Como resultado, este artigo apresenta as necessidades informacionais do pequeno e médio varejista brasileiro ao público acadêmico, de forma organizada e sistemática. O cuidado do pequeno e médio varejista com a informação, embora negligenciado, se torna a cada dia mais essencial para a sobrevivência dessas empresas à medida que o mundo se torna mais conectado.
Predicting the surface roughness and Tolerance using regression analysis while performing a boring operation in AA6061 Alloy
Authors: Pala Manohar , Biswal Shatabdi , Sarma Karumanchi Viswanatha , H Abdul Hameed , V Mahesh
Published: February 2025

Aluminium alloys are widely used in aerospace applications and AA6061 is one of the popular alloy which is extensively used in spacecraft mechanical hardware. Some of the mechanical hardware of spacecraft mechanisms call for stringent tolerances in larger diameter holes. These holes are achieved through boring operation on CNC machining centre by utilizing precision boring head and boring bar. Surface roughness and tolerance of the hole plays an important role in functioning of the system. In the current work experiments are carried out to study the significant input process parameters which influence the surface roughness and tolerance of holes. This was done using ANOVA. Also, a model was developed based on linear regression analysis. It was found that optimum cutting parameters predicted by Taguchi method improved surface finish and tolerance of holes
The Influence of Project-Based Learning (PjBL) on Students' Skills and Creativity in Drawing Network Installation Layouts at PTI UNDIKMA, Indonesia
Authors: Safitri Baiq Rina Amalia , Juliansyah Akbar , Hajiriah Titi Laily
Published: February 2025

This study aims to explore the influence of Project-Based Learning (PjBL) on the material of drawing network installation layouts in the PTI Study Program at Mandalika University of Education (UNDIKMA). The research method employed was a one-group pretest-posttest design. The research subjects consisted of 30 PTI students. Data analysis techniques included descriptive data analysis for mean measurement and inferential statistics for testing the significance of the t-test values. The pretest scores for skills and creativity before using PjBL-based Learning were 45.33 and 43, respectively. Post-test scores for skills and creativity after using PjBL-based Learning in drawing network installation layouts were 85 and 85.83, respectively. The difference between pretest and post-test scores, referred to as the gain scores, for skills and creativity were 39 and 41, respectively, with N-gain indices of 0.7, categorised as high. Hypothesis testing using a paired sample t-test for skills and creativity resulted in a two-tailed t-value of 0.000, which is smaller than the alpha value of 0.05, indicating that Ha is accepted. This shows that Project-Based Learning (PjBL) can enhance students' skills and creativity in drawing layouts for the network installation course.
Daylighting Performance Assessment: A Review of Methodologies
Authors: Ayoosu Moses Iorakaa , Utsaha Aondover Lawrence , Gabriel Kole Emmanuel , Vishigh Aker Mark Manasseh , Tuleun Memshima Evelyn , Sen Iwua Gabriel
Published: February 2025

This review assesses various methodologies in evaluating daylighting performance, highlighting their strengths and limitations. Key methods include computer-aided simulations, field measurements, physical scaled modelling, and mathematical calculations. Computer-aided simulations offer detailed and accurate predictions but require specialised skills, resources, and validation for accuracy. Field measurements provide empirical real-time data, though they are resource-intensive and need more time. Physical scaled models offer tangible insights but may lack precision, while mathematical calculations are quick and accessible yet often simplified and applicable to small tasks. However, designers can enhance the efficacy of daylighting assessments by integrating multiple methods, investing in training and tools, prioritising real-world testing, and adapting strategies to local contexts. Continuous monitoring and holistic design approaches are essential for optimising natural light use, improving energy efficiency, and ensuring occupant comfort in sustainable building environments. The review provides a valuable guide for researchers, architects, and engineers in selecting and combining appropriate methodologies for practical daylighting performance assessment.
Exploring Quantum-Inspired Algorithms for High-Performance Computing in Structural Analysis
Authors: K.M. Monica  , M. V. B. Murali Krishna  , S. Thenappan  , T. Sam Paul  , Sathiya Priya Shanmugam  , Tatiraju V. Rajani Kanth
Published: February 2025

Structural analysis in high-performance computing (HPC) faces challenges related to computational complexity, energy efficiency, and solution accuracy. This research explores Quantum-Inspired Algorithms (QIAs) as an innovative approach to enhance computational efficiency and accuracy in large-scale structural simulations. The proposed methodology integrates a Quantum-Inspired Evolutionary Algorithm (QIEA) with a Hybrid Quantum-Inspired Neural Network (HQINN) for improved structural performance prediction. The study evaluates QIAs on three benchmark structural problems: Bridge Load Distribution Analysis – Achieves a computational speed-up of 45% compared to classical solvers while maintaining an error rate of <0.5%. The Quantum-Inspired Variational Monte Carlo (QIVMC) method is applied to solve complex eigenvalue problems, achieving an 8× acceleration in solving large-scale stiffness matrices compared to traditional iterative solvers. Experimental validation on a high-performance computing cluster using 1,024 cores demonstrates a 55% improvement in processing speed and a 37% reduction in energy consumption. Results confirm that Quantum-Inspired Algorithms significantly outperform traditional numerical methods in structural analysis, paving the way for their adoption in next-generation engineering simulations. Future work will focus on hybrid quantum-classical frameworks and their real-world applications in civil, aerospace, and automotive engineering.
Student Interest Performance Prediction Based On Improved Decision Support Vector Regression Using Machine Learning
Authors: Mathivanan Durai  , R. B. Dravidapriyaa  , S.P. Prakash  , Wanjale Kirti Hemant , M. Kamarunisha  , M. Karthiga
Published: February 2025

The economic success of a government relies on the capability of its citizens to afford higher education. Ensuring maximum importance is given to this case is a crucial task for any government. However, the cost of education is affected by the amount of time students study before graduation. Moreover, one of the main obstacles facing universities is analyzing performance, proposing ways to improve the quality of education, and developing strategies to evaluate future practices. However, there is a lack of effectiveness and accuracy in standards for areas such as planning, leadership, online learning, student support, and assessment. To solve this problem, we use the Improved Decision Support Vector Regression (IDSVR) method to identify and determine the degree of quality verification for training schemes. Firstly, we used the Preferred Learning Materials Acquisition (PLMA) method to assess the similarity between student's learning and s behaviors. After that, the Lion and Krill Herd Optimization Algorithm (LKHOA) can be utilized to generate an efficient method for feature extraction.  Finally, the IDSVR classification system can be used to identify and evaluate the level of quality assurance implementation in training programs based on Machine Learning (ML) techniques.
BROWN BEARS’ TERRITORY MARKING ACTIVITY IN THE HUNTING AREAS OF SKOVORODINSKY DISTRICT IN THE AMUR REGION
Authors:   Amur Branch of Russian Association of Public Unions of Hunters and Fishermen, Pavlov A.M.
Published: February 2025

Brown bear’s territory marking activity has been widely studied in many countries. However, in
recent time practically there were no studies in this particular sphere as well as in general research
into brown bear ecology in the Amur Region. The latest researches into these issues date back to the
1980-1990’s (Yudin), and present exclusively summarizing studies of bear populations on the Khabarovsk and Primorsky Territories. The habitat area of the studied subspecies (Ursus arctos lasiotus)
is relatively small – Amur Region, Khabarovsk and Primorsky Territories, Sakhalin Island, South Kuril Islands, Hokkaido Island (Japan) and the north-eastern part of China’s Heilongjiang Province. The study of brown bears’ territory marking activity will give answers to many questions concerning the species ecology. The obtained information will help to confirm or disprove the data on
the species numbers and density in various types of territories, communicative relations within their
population, as well as the general condition of the brown bear population in the area under study.
Dualisme Sistem Pendidikan di Indonesia (Studi Kasus MAN 2 Kudus dengan Madrasah Aliyah Swasta)
Authors: Untsa Wif Da
Published: February 2025

Education can not apart from the education system itself. The education system implemented in educational institutions has a big role in determining student output. Educational institutions at the top level, for example at the high school level which incidentally under the Ministry of Education and Culture certainly have different goals from education at the level of MAN under the auspices of the Ministry of Religion. Judging from the output objectives to be achieved only conflict between one another, plus the compilation of the two education systems put together then what happens is the output of the educational institution will be half measures, so that the goals mentioned earlier can be used in accordance with what has been is expected. The writing of this article discusses the challenges of dualism in the education system in Indonesia by using literature and comparative studies, as well as discussing the implications arising from this dualism, and being able to provide contributive solutions in the arena of Indonesia's education world.
Strategi guru pembelajaran guru PAI dalam menangani kemunduran karakter siswa di SMP N 03 Randublatung Blora
Authors: Kresnaningtyas Aisyah , Tsaniyah Naimatus
Published: February 2025

This research uses a qualitative approach. Data collection techniques there are methods used,Â  Namely, observation, documentation, and interviews. The data analysis uses there stages namely, data reduction, data presentation, data verification and drawing conclusions from the results of the study. Respondents who were the source of information were the principal, counseling, guidance teacher, student for students, PAI Teacher and Student, PAI Teacher and Students. The results of this study can concluded as Follows: (1) the exemplary strategy, (2) the advice strategy, (3) confidence, and control, the reward and punishment strategy
KAJIAN METODE DISCOVERY LEARNING DAN RESITASI DALAM MENINGKATKAN MINAT BELAJAR IPA SISWA SD
Authors: Lutfi Rima , Purnasari Nurwulan
Published: February 2025

This research aims to review the application of discovery learning methods and recitation methods towards student's learning interest in primary school. This research uses meta-analysis model and the data was collected from theories and research result in e-journal from Google Cendekia and IAIN's library. Data analysis performed with a qualitative descriptive step. This study revealed that discovery learning methods was able to increase student's learning interest between 11% until 49% with average point 21,39%. Based on the results of the analysis, it concluded that the application of discovery learning methods and recitation learning methods in learning could increase primary student learning interest, especially in science subjects.
Citizenship Education to Strengthen Student Character
Authors: Baidi Baidi , Hibana Hibana , Surahman Susilo
Published: February 2025

Since the era of President Sukarno, citizenship education has been taught precisely from around 1901 to 1970, but in the learning process, students still find some obstacles. This study aims to determine the implementation of citizenship education learning in strengthening students' characterâ€”qualitative field research method with a descriptive approach. The research was conducted at Integrated Islamic Primary School Salsabila Banguntapan Yogyakarta.Â Data collection techniques through observation, interview and documentation. The validity of the data is obtained by triangulation. Data analysis techniques using Miles and Huberman's theory are with stages of data reduction, display and conclusion drawing. The research results are 1) education learning planning is made in the syllabus and character education learning plan. 2) In the learning process, the teacher applies and uses various methods and learning resources and integrates them into characterful activities. 3) evaluation is done by the teacher through assessment, although not optimal.
Nilai-Nilai Pendidikan Budi Pekerti dalam Buku Teks Mata Pelajaran Sejarah Kebudayaan Islam
Authors: Mulyaningsih Alrita , Hakiman Hakiman
Published: February 2025

In the 2013 curriculum, character education is integrated into the subject book by including it in Core Competencies (KI) 1 and 2, religious attitudes and social attitudes. The textbook of Islamic Cultural History (SKI) is one of the books mandated to contain these competencies. Through the stories of the life journey of Rasullulah and his friends, as well as figures who colored the development of the Islamic world, it is hoped that students can take worship and can emulate the attitudes and characteristics of Rasullulah. The purpose of this study was to describe the values of character education in Islamic Culture History Subject Texbooks for class X Madrasah Aliyah odd Semesters. This study uses literature research with a descriptive approach. The values of character education contained in the textbook of Islamic Cultural History class X MA in the odd semester include religious values, nationalist values, independence values, integrity values, and mutual cooperation values
Evaluasi Sekolah dan Madrasah Melalui Sistem Akreditasi dalam Kebijakan Pendidikan di Indonesia
Authors: Astuti Puspa Yuli , Diantoro Fery
Published: February 2025

Improving the quality of schools/madrasahs is carried out by means of guidance by the Education Quality Assurance Institution.Â After conducting quality development, it is necessary to carry out an evaluation using an accreditation system that has been regulated in education policy in Indonesia.Â Â Evaluation of schools/madrasahs is very important because it will have an impact on the quality of education and subsequent education policy makers.Â Â Therefore, this paper specifically aims to describe the evaluation of schools/madrasahs through the accreditation system.Â Â The method used in this paper uses a qualitative research obtained from the literature study.Â Â While the theory used in this paper is descriptive analysis. Regarding the results obtained from this paper is a description of the mechanism of the accreditation system in evaluating schools/madrasas as a form of improving the quality of schools/madrasas.Â Â Assessment and evaluation activities are carried out based on predetermined criteria and refer to the National Education Standards.Â Â The accuracy of the results of the evaluation of schools/madrasahs has contributed to the government as an effort to improve the quality of education and the determination of further education policies.
Implementasi Model Dick and Carey dalam Pengembangan Pembelajaran Pendidikan Agama Islam di Sekolah Dasar
Authors: Nurul Husna
Published: February 2025

The ability to design learning plans is a skill that every educator must have. The Dick and Carey model is a design approach that offers a systematic and structured process, in accordance with the competencies needed in Islamic Religious Education (PAI) learning. This research implements a field research model with a descriptive qualitative approach. This research was conducted at SDN 258 Voluntary Bandung City which aimed to see the results of the implementation of the Dick and Carey model in the development of PAI learning in elementary schools. The research data was obtained from interviews with Islamic Religious Education teachers and students. Observations were made on the implementation of the Dick and Carey model in the PAI learning process. Documentation in the form of a review of teaching modules. Analysis techniques include data reduction, data verification and conclusions. The results of the study stated the steps applied in the implementation at SDN 258 Voluntary including first, identifying learning objectives Second, conducting teaching analysis. Third, identify data on students' behavior and their personalities. Fourth, describe the purpose of performance. Fifth, formulate benchmark reference test items. Sixth, use relevant learning strategies. Seventh, sort and develop teaching materials. Eighth, designing and developing formative evaluations in the form of teaching and learning activities. Ninth, revise the learning program.
Revitalisasi PAI melalui Inovasi Teknologi: Menghadapi Era Digitalisasi
Authors: Syauqi Musfirah
Published: February 2025

The objective of this research is to identify the updates in Islamic Religious Education (PAI) through the utilization of new technologies in the context of constant digitization. Islamic religious education plays a crucial role in the lives of Muslims. To keep pace with current developments, Islamic religious education is also adapted and redesigned to continuously align with the needs of today's society. Technology plays a significant role in these changes. Questions arising include: How can new technologies be employed in Islamic religious education in the digital era? In the age of digitization, will technological innovations have a positive impact on Islamic religious education? This research involves a literature review that examines articles, journals, and academic literature related to Islamic boarding schools (pesantren) and their development. Secondary data from relevant books and research findings are used as data sources. The data collection method employed is a literature review. The findings of this research indicate that the digital era should be seen as a golden opportunity to maximize the potential of Islamic religious education and educate a generation with strong moral values and character. Thus, Islamic religious education will be able to play its role and strengthen its presence in the midst of global civilization by offering creative solutions in the field of education both in the present and the future.
Makine Öğrenmesi ile Kestirimci Bakım ve Yedek Parça Yönetimi
Authors: Ersöz Olcay Özge , İfraz Metin , Tebrizcik Semra , İnal Ali Fırat , Eskicioğlu Ömer Can , Aktepe Adnan , Türker Ahmet Kürşad , Barışçı Necaattin , Çetinyokuş Tahsin , Ersöz Süleyman
Published: February 2025

İşletmelerin müşterilerine sundukları hizmetlerin aksamaması için araç, makine vb. kaynaklarını verimli ve etkin kullanması gerekmektedir. İşletme kaynaklarının daima hazır ve çalışır olması için bakım süreci kritik önemdedir. Ayrıca, bakım ve onarım işlemleri için ihtiyaç duyulan yedek parça ile sarf malzemeleri işletme giderlerinde önemli bir pay oluşturmaktadır. Bu nedenle bakım departmanlarında başarılı bir bakım ve envanter yönetimi işletmelere birçok boyuttan kazanç sağlamaktadır. Bu çalışma da bir otobüs filosunda envanter yönetimi ile kestirimci bakım planlarını entegre eden dinamik bir model önerilmiştir. İşletmeye ait veriler üzerinde makine öğrenmesi ve derin öğrenme algoritmaları ile ortalama arıza kilometre tahminleri yapılmıştır. Makine öğrenmesi algoritmaları kullanılarak %95 R2 değeri ile yüksek tahmin başarısı sağlanmış ve kestirimci bakım çalışmasından elde edilen bakım planlarına göre envanter yönetim çalışması yürütülmüştür. Önerilen envanter yönetimi modeli ile yılda ihtiyaç duyulacak yedek parça miktarları, emniyet stokları, yeniden sipariş noktaları ve sipariş miktarları belirlenmiştir. Gerçekleştirilen çalışma, en önemli on adet yedek parça için test edilmiş ve stok maliyetlerinde %2,11 düşüş sağlanmıştır.
Observational Study: Examining the Meteorological Relationship Between Subarachnoid hemorrhage
Authors: Zortuk Ökkeş , Mutlucan Umut Ogün , Bedel Cihan , Selvi Fatih , Türk Cezmi Çağrı
Published: February 2025

Background :Subarachnoid hemorrhage (SAH) is a critical condition involving bleeding into the subarachnoid space, commonly presenting with severe headache, nausea, vomiting, dizziness, and loss of consciousness. It is a significant cause of morbidity and mortality, especially in middle-aged and elderly populations, with many deaths occurring within the first 24 hours of hemorrhage onset. Some studies suggest a potential link between SAH and weather conditions, but findings are inconclusive.

Aims: This study aims to investigate the relationship between climatic conditions and the incidence of SAH, focusing on variables such as air temperature, dew point, humidity, weather conditions, wind speed, and atmospheric pressure.

Methods: A retrospective study was conducted on patients diagnosed with SAH and admitted to a tertiary care hospital's emergency department between January 1, 2023, and December 31, 2023. Inclusion criteria were definitive diagnosis of SAH in patients aged 18 and older and subsequent hospitalization. Weather data at the time of SAH diagnosis were retrospectively reviewed, including daily average air temperature, dew point, humidity, weather conditions, wind speed, atmospheric pressure, and precipitation. Data were analyzed using SPSS 25.0, employing Pearson chi-square and Fisher's exact test for group comparisons.

Results: The study included 309 SAH patients. Significant findings include a lower average dew point and higher wind speed and atmospheric pressure on days with SAH admissions. SAH incidence was higher on fair and cloudy days. The lowest SAH prevalence was in June, while the highest was in January. Seasonal analysis showed the highest prevalence in spring and the lowest in autumn.

Conclusion: SAH incidence varies by month and season, decreasing in June and autumn. Climatic conditions, particularly dew point, wind speed, and atmospheric pressure, are associated with SAH occurrence. Further research is needed to fully understand the impact of weather on SAH risk.
Relationship between the Coronary Slow Flow Phenomenon and the Vertebrobasilar Insufficiency
Authors: Yüksel Yasin , Yildiz Cennet , Rakici İbrahim Taşkın , Erkol Cansu , Çağlar Fatma Nihan Turhan
Published: February 2025

Background: Coronary slow flow phenomenon (CSFP) and vertebrobasilar insufficiency (VBI) may have common pathophysiological mechanism.

Aim: Our aim was to investigate whether there is an association between vertebrobasilar flow assessed by Doppler sonography and CSFP assessed by Thrombolysis in Myocardial Infarction (TIMI) frame count.

Methods: We included 241 patients who had CSFP and underwent vertebrobasilar Doppler sonography. Patients with vertebral artery blood flow volumes greater than 200 ml/min and equal to or less than 200 ml/min were classified into the normal flow and low flow groups, respectively. Hospital records were used to determine the biochemical and demographic characteristics of the patients.

Results: The mean age of the study population was 58.75±9.34 years. We found no differences between patients with normal and low vertebral blood flow in terms of age, sex, body mass index, smoking habit, presence of hypertension, hyperlipidemia, diabetes mellitus or medication use. Patients with low vertebral blood flow were found to have greater mean platelet volume. The mean TIMI frame count and LAD, Cx, and RCA TIMI frame counts were significantly greater in patients with low vertebral blood flow and were negatively correlated with the vertebral artery blood flow volume (p<0.001 for all). A mean TIMI frame count of 24.5 predicted VBI, with a sensitivity and specificity of 61.2% and 86.8%, respectively. The only predictor of VBI was the mean TIMI frame count (OR: 1.066, 95% confidence interval: 1.043–1.091, P<0.001).

Conclusion: Our findings suggest that a common pathophysiological mechanism may underlie both CSFP and VBI.
Kelekak Agroforestry in Central Bangka, Indonesia: Species Diversity, Challenges, and Conservation Strategies
Authors: Al Manar Primadhika , Zuhud Ervizal Amir Muhammad , Hikmat Agus , Hidayat Syamsul , Robika  , Meilanto  , Wilyan Radil , Munggaran Ikram Kurnia
Published: February 2025

Forest land conversion has caused global climate change, reducing biodiversity and food security challenges. Climate change’s influence on food security must be anticipated promptly by adopting an adaptable agricultural cultivation system, such as agroforestry. The Bangka community is one of many that continue to practice agroforestry. In the Bangka community, agroforestry is known as kelekak. This research aims to learn about the history, variety of species, challenges, and conservation strategies of kelekak. This study's data was gathered through interviews, field observations, and literature studies. Kelekak is a woodland region historically used by the community to produce dryland rice (ume), which later became kelekak agroforestry land. Several fruit plant species are commonly found on kelekak land, including durian (Durio zibethinus), mangosteen (Garcinia mangostana), cempedak (Artocarpus integer), and ketapi (Sandoricum koetjape). The community utilizes various plant species in the kelekak as food, medicine, building materials, and firewood. Kelekak’s survival is threatened by land conversion to monoculture plantations, limiting community resource access. Efforts to revive the kelekak can be achieved through the Tri Stimulus Amar Pro-Konservasi approach by integrating natural, benefit, and religious willingness stimulus. Efforts to reinvigorate kelekak must begin immediately, with mapping activities for the remaining kelekak in the Central Bangka area to provide primary data for future kelekak development and local government regulations to conserve kelekak.
Keywords: agroforestry, conservation, food, forest, kelekak
The Content of reducing sugar in Siwalan juice (Borassus flabellifer L) before cooking and after cooking
Authors: Ngginak James
Published: February 2025

Gula reduksi merupakan salah satu zat gizi makro penting sebagai sumber energi. Kadar gula reduksi yang tinggi dalam suatu bahan pangan ditandai dengan cita rasa yang manis. Penelitian ini dilakukan di Laboratorium FST Kimia Undana. Tujuan penelitian adalah untuk mengetahui kandungan gula reduksi pada nira siwalan (Borassus flabellifer L) sebelum dimasak dan setelah dimasakan. Penelitian ini menggunakan metode eksperimen. Data penelitian dianalisis menggunakan deskripsi kuantitatif. Hasil penelitian menunjukkan bahwa pada sampel sebelum dan sesudah pemasakan mengandung gula reduksi. Gula reduksi yang terkandung mempunyai konsentrasi yang berbeda. Sampel sebelum dimasak memiliki kadar gula reduksi 1,49 % dan sesudah dimasak 15.65 %. Variable lain yang diukur dalam penelitian ini adalah kadar air dan suhu. Kadar air pada sampel sebelum pemasakan adalah 51,69 % dan sesudah pemasakan 26,78 % sedangkan suhu sampel sebelum pemasakan yaitu 230C dan 230C setelah pemasakan. Dalam penelitian ini terjadi perubahan fisik pada sampel setelah perebusan atau pemasakan. Perubahan fisik yang bisa diamati sebelum dan sesudah pemasakan yaitu setelah pemasakan sampel terbentuk karamel, warna yang coklat dan aroma gula yang khas. Semua rangkaian perubahan pada sampel ini dipengaruhi oleh perlakuan panas atau suhu.
Kata- kata kunci : Gula, Gula reduksi, Pohon lontar, Nira, Pemasakan
Karakteristik Habitat Perkembangbiakan Aedes aegypti di Desa Gosoma, Halmahera Utara, Indonesia
Authors: Boleu Fiktor Imanuel
Published: February 2025

Tujuan penelitian ini adalah untuk mengetahui karakteristik lingkungan biotik dan abiotik habitat perkembangbiakan Ae. aegypti sebagai vektor demam berdarah di Desa Gosoma, Kecamatan Tobelo, Kabupaten Halmahera Utara. Studi observasional dengan melakukan survei larva pada setiap titik pengambilan sampel dan identifikasi terhadap faktor biotik dan abiotik. Karakteristik lingkungan abiotik diperoleh hasil pengukuran suhu udara berkisar antara 28-32 °C, kelembaban 64-83%, dan intensitas cahaya 450-1780 lux. Sementara suhu air berkisar antara 25-30 °C dan pH 6,4-7,6. Densitas larva tertinggi ditemukan pada daerah rawa sebanyak 31 larva per 250 ml. Inventarisasi vegetasi (faktor biotik) diperoleh 23 jenis tumbuhan pada 8 stasiun pengamatan. INP kumulatif yang tinggi pada tingkat rumput-rumputan dan herba adalah Cyperaceae 264,95% dan Ipomea aquatic 210,32%. Jenis perdu yang dominan adalah Carica papaya 123,67%, Citrus microcarpa 106,68%, dan Areca catechu 89,93%. Sementara jenis pohon yang dominan adalah Ficus septica 300,00%, Mangifera indica 170,51%, Nephelium lappaceum 150,00%, Cocos nucifera 130,14%, Terminalia catappa 123,33%, dan Myristica fragans 120,86%. Habitat perkembangbiakan nyamuk sebagai vektor demam berdarah berada di wilayah pemukiman penduduk.
Inventarisasi Jenis Burung Di Habitat Hutan Desa Waai Kabupaten Maluku Tengah
Authors: Silahooy Veince Benjamin , Huwae Laury Marcia Chara , Pentury Kresyan
Published: February 2025

Birds are an important component in a forest ecosystem. Birds play a role in pollination, seed dispersers, pest control, and even their droppings provide nutrients for the soil. After the earthquake in Ambon and surrounding areas in September 2019, many people fled to the forest. This research was conducted in Waai village to inventory the species of birds in the forest (HA) and forests that were converted into post-earthquake refuge (HP) using the list of bird species and natural sciences. The results show that 8 species of birds were found at the HA location while 3 species of birds were found at the HP location. The highest species abundance was Passer montanus at both locations. The lowest abundance value on HA is Todirhamphus chloris and Ducula bicolor, while on HP is Leptocoma aspasia. Diversity index analysis shows 1.67 index on HA and 0.86 on HP.
Keanekaragaman dan Kemelimpahan Jenis Anggrek (Orchidaceae) di Resort Selabintana Taman Nasional Gunung Gede Pangrango (TNGGP) Jawa Barat
Authors: Prapitasari Bela
Published: February 2025

Gede Pangrango National Park (TNGGP) of West Java is one of the National Park that conserve orchid species. This study aims to determine what orchid species are found in Selabintana TNGGP, the most dominant orchid species found, determine the level of diversity of orchid species (H’), and determine the host tree used as epiphytic orchid habitat. The study was conducted at Selabintana TNGGP at two different location namely Cibereum Curug path and climbing path (altitude 1.500 asl). The data collection method is carried out using Visual Encounter Survey (VES) along the path with a radius to the right and left of one meter. The results found 46 types of orchids (25 epiphytic and 21 terestrial). The most dominant species found in the Curug Cibereum path is Erythrodes brevicalcar (137/ individual count 8.000 m2 ) and the most dominant species found in the climbing path is Liparis odorata (52 individual count/8.000 m2). The level of species diversity (H’) of orchids in Selabintana is classified as moderate ( Curug Cibereum path: 2,7; climbing path: 2,1). Host trees used as epiphytic orchid habitat are Schiima walici, Ficus sp, Cyathea sp, Dendronicde stimulans, and fellen branch.
Keywords: Orchidaceae,  Gede Pangrango National Park, Diversity, Host trees.
Analisis Penalaran Ilmiah Siswa pada Penggunaan Media Analog Proses Pembentukan Urine
Authors: Luzyawati Lesy , Hamsyah Devitia , Dewi Lian Novita
Published: February 2025

Penalaran ilmiah perlu ditanamkan sejak dini pada tingkat satuan pendidikan abad ke 21 karena siswa harus dapat berperan seperti peneliti. Salah satu acuan dalam menentukan penalaran ilmiah adalah media alat peraga yang dapat membantu dalam pemahaman siswa dengan materi yang abstrak. Penelitian ini bertujuan untuk mengetahui penalaran ilmiah siswa pada penggunaan alat peraga proses pembentukan urin. Metode yang digunakan adalah metode deskriptif dengan sampel 26 siswa di kelas XI MIA 3 di MAN 1 Indramayu. Data diperoleh dari hasil observasi dan tes essay. Test essay berjumlah 8 soal, masing-masing soal termasuk dalam aspek Integrated, Advented dan Culminating. Data hasil observasi menunjukkan penalaran ilmiah pada aspek integrated skor 73,3 berada pada kategori tinggi, advenced skor 63 berada pada kategori tinggi dan culminating skor 57,8 berada pada katagori sedang. Sedangkan data hasil test menunjukkan penalaran ilmiah pada aspek integrated skor 67 berada pada kategori tinggi, advenced skor 56  dan culminating skor 52,8 keduanya berada pada katagori sedang. Dengan rata-rata hasil observasi dari tiga aspek tersebut menunjukan skor 64,7 berada pada kategori tinggi dan rata-rata hasil test menunjukan skor 56,8 berada pada kategori sedang. Secara keseluruhan kemampuan penalaran ilmiah siswa berada pada kategori sedang.
KORELASI SELF CONFIDENCE DENGAN KEMAMPUAN PEMECAHAN MASALAH PESERTA DIDIK PADA MATERI KEANEKARAGAMAN HAYATI
Authors: Azhari Dini nabila
Published: February 2025

This research is a correlational study which aims to determine the correlation of self-confidence with problem-solving abilities of students in biodiversity material. The population in this study were all class X as many as seven classes consisting of 251 students. The sample of this research is class X MIPA 3 as many as 30 students as participants with the sampling technique using purposive sampling. The research instruments used were description questions to measure problem-solving abilities and questionnaires to measure students' self-confidence. The instrument of problem solving ability was measured using descriptions of biodiversity material consisting of 30 questions. Meanwhile, the self confidence questionnaire consisted of 32 statements. Each item has an alternative answer that shows the degree of suitability or non-suitability with the subject. Alternative answers consist of four options, namely very suitable (SS), suitable (S), not suitable (TS), and very unsuitable (STS). Before testing the hypothesis, the normality test and linearity test are performed first as a prerequisite analysis test. Hypothesis testing used Pearson bivariate correlation. The results showed that there was a strong relationship between self-confidence and problem-solving abilities of students in biodiversity material.
IDENTIFIKASI JENIS-JENIS TUMBUHAN LUMUT HATI (MARCHANTIOPHYTA) DI HUTAN CAGAR ALAM SITU PATENGGANG
Authors: Supandi Gurnita
Published: February 2025

Hutan Cagar Alam Situ Patenggang merupakan kawasan konservasi yang ada di Jawa Barat dengan biodiversitas yang tinggi, salah satunya adalah lumut hati. Penelitian ini bertujuan untuk mengetahui jenis-jenis tumbuhan lumut hati yang ditemukan di Hutan Cagar Alam Situ Patenggang. Metode yang digunakan dalam penelitian ini adalah metode deskriptif dengan desain penelitian belt transect dan teknik pengambilan sampel dengan purposive sampling. Penggunaan transek sepanjang 1200 meter, setiap 200 meter dibuatkan plot berukuran 10x10 m2. Data yang diambil adalah spesies dari jenis lumut hati dan data pendukung faktor lingkungan (suhu udara, intensitas cahaya, kelembaban udara, kelembaban tanah dan pH tanah). Identifikasi data dilakukan di Laboratorium Biologi, FKIP Universitas Pasundan Bandung. Hasil identifikasi menunjukan bahwa jenis lumut hati yang ditemukan di Hutan Cagar Alam Situ Patenggang teridentifikasi sebanyak 9 spesies yang termasuk kedalam 2 kelas, 4 ordo, 7 famili dan 9 genus.
Uji Perilaku dan Preferensi Area pada Ikan Zebrafish (Danio rerio) yang Diinduksi Stres
Authors: Darniwa Adisty Virakawugi , Cahyanto Tri , Eka Putri Zashika Meidita , Kusumorini Astuti , Ulfa Risda Arba , Adawiyah Ayuni , Hizqiyah Ida Yayu Nurul
Published: February 2025

Sistem stres ikan zebra diwakili oleh poros HPI yang serupa dengan poros HPA pada mamalia untuk mengendalikan sirkulasi kortisol sebagai hormon terkait respon stres. Ikan yang berada dalam keadaan stres diduga mempengaruhi perilaku dan preferensi area sesuai dengan parameter yang ditentukan. Tujuan dari penelitian ini adalah menguji efek induksi stres suhu terhadap preferensi area dan perilaku ikan zebra. Penelitian ini dilakukan secara eksperimental dengan parameter uji: preferensi area gelap/terang, preferensi area bawah/atas, dan munculnya perilaku imobilitas dan gerakan tidak menentu. Ikan diamati di tiga akuarium uji secara individual, yaitu akuarium uji gelap/terang, akuarium tangki penyelaman (atas/bawah), dan akuarium uji lapangan terbuka. Data dianalisis secara statistik menggunakan  Uji T berpasangan dengan signifikansi P < 0,05. Stres suhu yang diberikan mempengaruhi preferensi area pada ikan zebra, preferensi pada area terang lebih tinggi (rata-rata 33,29 detik/menit) dibandingkan area gelap, preferensi pada area bawah akuarium lebih tinggi (rata-rata 44,96 detik/menit) dibandingkan area bawah, dan perilaku berupa imobilitas dan gerakan tidak menentu ditunjukan oleh ikan zebra sebagai indikasi respon stres. Disimpulkan bahwa perilaku dan preferensi area terpengaruh oleh paparan stresor suhu yang diduga terkait dengan produksi kortisol.
STRATEGI PEMASARAN DI PEGADAIAN (PERSERO) CABANG ANJATAN KABUPATEN INDRAMAYU, JAWA BARAT
Authors: 2 Guest
Published: February 2025

Strategi pemasaran saat ini dijadikan sebagai tolak ukur bagi perusahaan dalam bersaing dengan perusahaan lain, yang bergerak dalam bidang yang sama atau sejenis untuk memperoleh banyak pelanggan dan mendapatkan keuntungan yang tinggi. Strategi pemasaran produknya dengan cara Cross sellingialah PT. Pegadaian menjual produk tambahan dan jasa yang telah disepakati untuk dibeli, Selain cross sellingjuga ada Up Sellingyaitu menawarkan produk yang nilai produknya lebih mahal daripada produk yang sedang /ingin dibeli konsumen. PT. Pegadaian menggunakan iklan melalui Instagram danfacebooksaja, Masyarakat kurang memahami penggunaan teknologi.
PENGARUH HARGA TERHADAP KEPUTUSAN PEMBELIAN KONSUMEN PADA PRODUK MAKARIZO HAIR ENERGY SHAMPOO DI PT AKASHA WIRA INTERNATIONAL JAKARTA SELATAN
Authors: Ratnasari Aulia Dewi
Published: February 2025

PT Akasha Wira International Tbk merupakan sebuah perusahaan yang bergerak pada bidang industri salah satunya kosmetika perawatan rambut Makarizo. Peneliti melakukan penelitian pada produk Makarizo Hair Energy Shampoo. Pada PT Akasha Wira International Tbk ditemukan masalah yaitu kurangnya minat beli pada produk Makarizo Hair Energy Shampoo yang berdampak pada penurunan volume penjualan di perusahaan, hal ini dikarenakan harga shampoo yang sedikit lebih tinggi membuat konsumen Makarizo Hair Energy Shampoo beralih menggunakan produk kompetitor sejenis yang lebih menarik perhatian konsumen. Tujuan dari penelitian ini adalah untuk memecahkan masalah yang terjadi dan dituangkan dalam sebuah penelitian. Metode yang digunakan dalam penelitian ini adalah kuantitatif, jenis penelitian ini deskriptif kuantitatif, dan sifat penelitian ini deskriptif eksplanatori. Metode analisis data yang digunakan adalah regresi linier sederhana. Sampel pada penelitian ini sebanyak 60 responden sebagai konsumen, sehingga teknik pengambilan sampel menggunakan rumus fungsi waktu. Hasil penelitian diketahui terdapat pengaruh Harga terhadap Keputusan Pembelian Konsumen pada produk Makarizo Hair Energy Shampoo ditunjukkan dengan persamaan regresi Y= 3,696 + 1,106 X. Nilai Koefisien Korelasi adalah 0,967 dan Koefisien Determinasi adalah 93,6%, sisanya dipengaruhi oleh hal lain yang tidak diteliti dalam penelitian. Hambatan yang dihadapi PT Akasha Wira International Tbk adalah harga yang lebih tinggi kurang menarik perhatian konsumen dibandingkan dengan kompetitor sejenis.
STRATEGI PENGEMBANGAN PRODUK UNTUK PENINGKATAN EKSPOR PADA IKM ELINA KERAMIK BANDUNG
Authors: Sukmawati Sukmawati
Published: February 2025

Tujuan dari penelitian ini adalah untuk menganalisis upaya yang dilakukan oleh IKM Elina Keramik dalam strategi pengembangan produk. Metode penelitian yang digunakan adalah kualitatif dengan teknik pengumpulan data primer, dimana peneliti melakukan wawancara mendalam dengan informan dan observasi non partisipan melalui hasil analisis independen peneliti saat melakukan penelitian di IKM Elina Keramik. Penelitian ini menghasilkan data berupa kata-kata terstruktur. Data yang terkumpul dianalisis melalui reduksi data, penyajian data, kemudian verifikasi atau penarikan kesimpulan data yang telah diuji validitasnya.