bluuebunny/crossref_metadata_2025 huggingface dataset:
CONCEPCIONES Y MODELOS ACERCA DE LA ENSEÑANZA DE LAS CIENCIAS NATURALES EN ESTUDIANTES DE LA LICENCIATURA EN PEDAGOGÍA INFANTIL DE LA UNIVERSIDAD TECNOLÓGICA DE PEREIRA (Pag: 95-116)
Authors: Villalba Baza Carlos Abraham , Tamayo Alzate Oscar Eugenio
Published: May 2017

Este estudio de tipo cualitativo pretende describir y comprender las concepciones y modelos acerca de la enseñanza de las ciencias naturales de 4 estudiantes de IX semestre de la Licenciatura en Pedagogía Infantil de la Universidad Tecnológica de Pereira. Estos estudiantes recibieron formación en didáctica de las ciencias naturales durante dos semestres de su carrera. Se emplearon como técnicas e instrumentos: el cuestionario, la entrevista semiestructurada, la revisión de planes de clase y la observación no participante. Se pudo concluir que las concepciones halladas apuntan al uso de términos como aprendizaje significativo, cambio conceptual, desarrollo de competencias científicas e indagación de las ideas previas, sin que profundicen conceptualmente en ellos, en contraste, en el desarrollo de las clases, se evidenciaron actividades de tipo memorístico y centradas en contenidos. De igual forma, se logró determinar que las concepciones y los modelos (de enseñanza en este caso) son resistentes al cambio, aunque pueden transformarse si se explicitan y trabaja con ellos. Los resultados de investigación aquí presentados pueden constituirse en un referente para planes de actualización del profesorado en ejercicio o en formación, utilizando como fundamento las concepciones y la modelización.
Por uma germanística “menor”: W. G. Sebald e a “pequena” literatura da periferia austríaca, e de outros lugares
Authors: Schütte Uwe
Published: May 2017

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Reflections on the Use of Perampanel in Epilepsy – Lessons from the Clinic and Real-world Evidence
Authors: Trinka Eugen ,   Department of Neurology, Christian Doppler Klinik, Paracelsus Medical University and Centre for Cognitive Neuroscience, Salzburg, Austria, Carreňo Mar ,   Epilepsy Unit, Hospital Clinic, Barcelona, Spain
Published: May 2017

Optimal epilepsy management includes five important elements: rational treatment selection, efficacy, off-target effects, adherence and interactions and dosing issues. Perampanel (2-[2-oxo-1-phenyl-5-pyridin-2-yl-1,2-dihydropyridin-3-yl]benzonitrile; E2007) is the first potent, selective, orally-active non-competitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist approved for the treatment of patients with epilepsy. Results from randomised controlled trials and real-world studies of refractory epilepsy populations treated with perampanel showed effective frequency reduction for both focal-onset seizures (without and with secondary generalisation) and for primary generalised tonic-clonic seizures. Perampanel therapeutic doses have been calculated to only inhibit a fraction of AMPA receptors, thereby to enable sufficient seizure control without substantial impairment of neurological function. Further investigation in special subpopulations of people with epilepsy, including the elderly and people with learning disability or psychiatric comorbidities, is warranted. With an average long half-life of 105 hours, perampanel may be more forgiving in circumstances of suboptimal adherence. Perampanel is not a strong inducer or inhibitor of cytochrome P450 enzymes, and dose adjustment is not always required for the elderly or for those with mild renal impairment.
Premonitory-like Symptomatology in Migraine
Authors: Karsan Nazia ,   Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK, Goadsby Peter J ,   NIHR and Wellcome Trust King’s Clinical
Research Facility, King’s College Hospital, London, UK
Published: May 2017

It has been historically accepted that migraine involves symptomatology outside of head pain. These symptoms can be as equally disabling as the pain, and can include tiredness, concentration impairment, memory impairment and mood change. The symptoms may start before the onset of pain and can persist throughout the headache phase, and even after effective headache treatment into the postdrome. Despite knowledge of these symptoms, their neurobiologic basis and relationship to migraine pain is poorly understood. The fact that these symptoms start early, up to hours to days before the onset of headache, and are so symptomatically heterogeneous, suggests that the neurobiology of migraine extends beyond conventionally accepted anatomical pain areas within the brain – what has been known as the pain matrix or network. In a research area where no effective acute abortive drugs have gained a license for migraine since the triptans (serotonin 5-HT1b/1d receptor agonists), in the 1990s, further understanding of such symptomatology will allow therapeutic advances for treatments that may work before the onset of migraine pain and thus prevent it. This review will outline our current understanding about the phenotype and neurobiology of the premonitory (prodromal) symptoms, which for the purpose of this review will be called ‘premonitorylike’, given they can start before or during pain. Symptoms starting after pain resolution (postdromal symptoms) will not be covered here.
Neurorehabilitation in Multiple Sclerosis – Resilience in Practice
Authors: Kesselring Jürg ,   Department of Neurology and Neurorehabilitation Rehabilitation Centre, Valens, Switzerland
Published: May 2017

In recent years, enormous strides have been made in increasing the range and efficacy of disease-modifying drugs available for the treatment of multiple sclerosis (MS) in its early and remitting stages, and more continue to emerge. Another equally important concept of successful treatment of MS is neurorehabilitation, which must be pursued alongside these medications. Key factors that contribute to the impact of neurorehabilitation include resilience and neuroplasticity. In the former, components such as nutrition, self-belief and physical activity provide a stronger response to the disease and improved responses to treatment. Neuroplasticity is the capacity of the brain to establish new neuronal networks after lesion damage has occurred and distant brain regions assume control of lost functions. In MS, it is vital that each patient is treated by a coordinated multidisciplinary team. This enables all aspects of the disease including problems with mobility, gait, bladder/bowel disturbances, fatigue and depression to be effectively treated. It is also important that the treating team adopts current best practice and provides internationally agreed standards of care. A further vital aspect of MS management is patient engagement, in which individuals are fully involved and are encouraged to strive and put effort into meeting treatment goals. In this approach, healthcare providers become motivators and patients need less intervention and consume fewer resources. Numerous interventions that promote neurorehabilitation are available, though evidence to support their use is limited by a lack of data from large randomised controlled trials. Combining interventions that promote neurorehabilitation with newer, more effective treatments creates a promising potential to substantially improve the outlook for patients at all stages of MS.
YOUNG ADULTS’ EXPERIENCES WITH NEAR-INJURY SITUATIONS: A CRITICAL INCIDENT STUDY IN SWEDEN
Authors: Dale Richard Allan , Sverker Annette , Hasselberg Marie , Östlund Gunnel , Hensing Gunnel
Published: May 2017

As injuries are the main health threat for young adults (18–29 years) in industrial countries, a better understanding of injury risk is needed for this population. Using the Critical Incident Technique, this study explores how young people experience situations that have the potential to cause physical injury (i.e., near-injury situations). Clearly, understanding how and why near-injury situations arise can be used to develop strategies to help prevent severe injury. Content analysis was used to categorize the characteristics of the experiences into unexpected risk in ordinary tasks, duty first, and price for learning. Young adults’ exposures to new or unusual environmental conditions, especially in unexpected risk in ordinary tasks, should be considered when planning injury prevention strategies. A combination of individual, social, and contextual demands and expectations was identified in both work- and sports-related experiences with near-injury situations. The price for learning, which arises from the added risk involved in learning situations, is another condition that was identified and requires further attention. The Critical Incident Technique proved to be a useful method for identifying near-injury situations that might otherwise have been difficult to recall. Young adults’ efforts to display their ability to handle difficult situations at work and in their everyday lives was identified as a major contributor to near-injury situations.
Diseño de un prototipo de sistema de realidad virtual inmersivo simplificado
Authors: Quintero Guerrero Christian David , Sierra Ballen Eduardo Leonardo , Sarmiento Manrique Wilson Javier
Published: May 2017

Este artículo presenta el diseño y construcción de un prototipo de bajo costo de un sistema inmersión virtual de dos pantallas. Se describen los detalles más importantes de la implementación y se muestran las ventajas y problemas de diferentes arquitecturas posibles para el montaje físico. Se construyeron tres prototipos, uno de mesa y dos de tamaño real, sobre los cuales se realizaron diferentes pruebas con animaciones creadas en un software de modelado y animación 3D.
A Study of the Coverage of Environment and Sustainable Development in Indian
English Dailies
Authors: Parveen Huma
Published: May 2017

The significance of the print medium as an effective form of mass communication has been
widely researched and recognized. It has been playing an important role in transforming and
educating the society. Newspapers are the primary print media that have been established to
have strong agenda setting potential. Newspapers require a higher degree of attention from
the readers as compared to other media, thus creating a long lasting impact on their minds.
Newspapers have been instrumental in covering developmental themes in addition to other
paramount issues. The earth’s environment has been witnessing continuous change with the
passage of time. With technological advances and unprecedented consumption of natural
resources, environmental conservation and sustainable development have assumed importance
like never before. In the wake of rising concerns about sensitizing the public and spreading
awareness about conserving the environment, the role played by media, particularly
newspapers, has become undisputable. The present study is designed to analyze the way
print media has been handling its responsibility in highlighting the actual cause behind the
issues of environment. The coverage given to the environmental issues and sustainable
development by major English dailies in India will be quantified and analysed to ascertain
how much importance these issues are receiving at the hands of print media. The paper will
also analyze the themes reported by these newspapers to attain sustainable development.
Introspection into the Battle over Broadcast Regulations in India
Authors: Majumdar Pallavi
Published: May 2017

Across the world, media entities are subjected to regulations following the universal perception
that media content and media operations radically influence political debate, social policies
and economic growth. This is accompanied by the tension of how to regulate the media and
how to secure a free independent media on the other. Though regulation of the media content
can take on several forms ranging from direct control of the government, guidelines from the
industry associations, pressure from advertisers or suggestions by the civil society groups,
it is normally aimed at protecting the public from perceived harm, or with enriching their
knowledge or appreciation of culture. In India, the state has zealously guarded its control
over broadcast news media, however, the emergence of new stakeholders in the postliberalization
era has resulted in a complex mesh of regulatory controls. This paper traces the
historical context of the broadcast regulatory framework in India and explores the various
sites of contestations between the various stakeholders, particularly the state and the
broadcasters, with specific reference to news on television.
Help-Seeking Behavior Among Moroccan, Romanian, and Ecuadorian Women Experiencing Intimate Partner Violence in Spain
Authors: Vives-Cases Carmen , La Parra Daniel
Published: May 2017

This study aims to identify different types of response to intimate partner violence (IPV) and help-related seeking behavior among Spain’s most numerous immigrant groups—Moroccans, Romanians, and Ecuadorians. Women reporting physical, sexual and/or psychological violence by a current or former intimate partner (n = 194) were selected from a cross-sectional study based on 1,607 surveys (2011). There are 84% of surveyed battered women who reported seeking help through informal and/or formal channels. The most frequently reported informal help-seeking behavior was talking with the abusive partner (from 63% to 83%). Moroccans identified social services (29.6%) and health care (25.9%) professionals as their most frequently used formal resources when seeking help. Approximately 32% of Ecuadorians and Romanians declared having reported their partners to the police. Among all of the women, seeking help through formal channels was more probable in cases where the severity of IPV was high (adjusted odds ratio = 5.69, 95% confidence interval [2.29, 14.12]). It is needed to increase professionals’ opportunities to intervene in cases of IPV before they become severe.
A Gendered Analysis of the Shadow of Sexual Harm Among a College Sample
Authors: Petitt Aimee , Linville Noelle , York Scott , Cook Carrie L.
Published: May 2017

This study uses survey methodology to examine correlates of fear of crime among men and women to discern the unique impact of risk perception, victimization, vicarious victimization, and fear of sexual harm on fear of crime. Recently, scholars have begun to examine fear separately by gender, which is vital given the unique experiences men and women have with fear and victimization. We examine two different types of fear of crime to determine whether the effects of these correlates differ by crime type across gender. Results suggest that fear of sexual harm and risk perception are the most important indicators of fear of crime for both genders; sexual harm fear is particularly impactful for female fear of violence. Race and ethnicity also have interesting impacts for male fear of violent crime because racial and ethnic minorities indicate more fear of violent crime than White males. The findings illustrate how imperative it is to continue to examine fear of specific types of crime as well as distinguish fear by gender.
Victim Alcohol Intoxication During a Sexual Assault: Relations With Subsequent PTSD Symptoms
Authors: Jaffe Anna E. , Steel Anne L. , DiLillo David , Hoffman Lesa , Gratz Kim L. , Messman-Moore Terri L.
Published: May 2017

This study examines associations between women’s alcohol intoxication at the time of sexual assault and posttraumatic stress disorder (PTSD) symptoms. Drawing on the dual representation theory (Brewin, Gregory, Lipton, & Burgess, 2010), we hypothesized that intoxication at the time of assault would be positively associated with both overall symptoms of PTSD and PTSD reexperiencing symptoms in particular. A total of 143 community women (ages 18–26 years; 71.3% European American) reporting sexual victimization completed questionnaires assessing severity of coercion involved in the assault, perceived level of intoxication at the time of assault, and current PTSD symptoms. Overall, results suggested that greater alcohol intoxication (but not alcohol use alone) was associated with more severe PTSD symptoms when controlling for severity of coercion. Furthermore, higher levels of victim intoxication at the time of the assault were most predictive of reexperiencing symptoms relative to the other symptom clusters.
Acute Alcohol Use, History of Homelessness, and Intent of Injury Among a Sample of Adult Emergency Department Patients
Authors: Jetelina Katelyn K. , Gonzalez Jennifer M. Reingle , Brown Carlos V.R. , Foreman Michael L. , Field Craig
Published: May 2017

Background: The literature is clear that adults who are currently homeless also have higher rates of intentional injuries, such as assault and suicide attempts. No study has assessed whether intentional injuries are exacerbated because of substance use among adults with a history of homelessness. Methods: Data were obtained from a cohort of adults admitted to 3 urban emergency departments (EDs) in Texas from 2007 to 2010 (N = 596). Logistic regression analyses were used to determine whether a history of homelessness was associated with alcohol use at time of injury in intentional violent injuries (gunshot, stabbing, or injury consistent with assault). Results: 39% adults with a history of homelessness who were treated at trauma centers for a violent injury. Bivariate analyses indicated that adults who had ever experienced homelessness have 1.67 increased odds, 95% confidence interval (CI) [1.11, 2.50], of any intentional violent injury and 1.95 increased odds (95% CI [1.12, 3.40]) of a stabbing injury than adults with no history of homelessness. Conclusions: Adults who experienced homelessness in their lifetime were more likely to visit EDs for violence-related injuries. Given our limited knowledge of the injuries that prompt ED use by currently homeless populations, future studies are needed to understand the etiology of injuries, and substance-related injuries specifically, among adults with a history of homelessness.
Soft Tissue Changes Around Immediately Placed Implants: A Systematic Review and Meta‐Analyses With at Least 12 Months of Follow‐Up After Functional Loading
Authors: Kinaia Bassam M. , Ambrosio Filip , Lamble Monica , Hope Kristyn , Shah Maanas , Neely Anthony L.
Published: May 2017

Background: Immediate implant placement (IIP) is predictable but can lead to esthetic challenges, including midfacial recession (MFR) and papillary height (PH) loss. The aim of this systematic review is to examine the effect of IIP on MFR and PH after at least 12 months of functional loading.

Methods: Literature review of the Cochrane and MEDLINE electronic databases and hand search up to January 2016 identified eligible studies. Four reviewers independently assessed data quality and methodology.

Results: A total of 106 articles satisfied the inclusion criteria. Twelve studies qualified for three meta‐analyses. MFR was slightly less in conventional implant placement (CIP) than in IIP, but the result was not statistically significant (mean difference [MD] −0.064 mm; P = 0.687). Similarly, there was better PH maintenance in CIPs, with statistical significance for distal PH (DPH) only (cumulative PH: MD −0.396, P = 0.010; DPH: MD −0.765, P <0.001; mesial PH [MPH]: MD −0.285, P = 0.256). MFR was slightly less in IIP with thick versus thin biotypes, but not statistically significantly different (MD −0.373, P = 0.243). Pooled data showed statistically significantly less MFR and better PH maintenance in IIP with thick biotype (MFR: MD −0.478, P <0.001; cumulative PH: MD −0.287, P <0.001; MPH: MD −0.288, P <0.001; DPH: MD −0.310, P <0.001). Non‐significantly less MFR (MD 0.253, P = 0.384) and significantly better PH maintenance were found in IIP with immediate provisionalization versus conventional restoration (MD −0.519, P = 0.028).

Conclusions: IIP in thick biotype and with immediate provisionalization had less MFR and better PH than IIP in thin biotype or with delayed restoration. However, these findings should be interpreted with caution due to high heterogeneity, which was calculated using comprehensive meta‐analysis statistical software that took into account sample size and different treatment groups, and limited qualified studies.
Glycated Collagen Stimulates Differentiation of Gingival Myofibroblasts
Authors: Retamal Ignacio N. , Hernández Romina , Melo Francisco , Zapata Paulina , Martínez Constanza , Martínez Jorge , Smith Patricio C.
Published: May 2017

Background: Glucose‐derived metabolites may alter the structure and biologic properties of important proteins in periodontium, such as collagens. As a consequence, it is possible that collagen‐binding cells may change their phenotypic traits. Although the glucose‐derived product methylglyoxal (MGO) has been detected in periodontal lesions, the precise effect of collagen glycation on gingival connective tissue biology is not fully understood. The present study evaluates whether collagen glycation by MGO may affect phenotypic properties and remodeling capacity of human gingival fibroblasts (HGFs).

Methods: Primary cultures of HGFs were grown on Type I collagen matrices previously treated with MGO. Cell cultures were tested for cell viability, apoptosis, α‐smooth muscle actin (SMA), fibronectin (FN) production, and collagen remodeling. Mechanical properties and morphology of MGO‐treated collagen gels were evaluated using rheometry and atomic force microscopy. Statistical analysis was performed by Kruskal‐Wallis and Mann‐Whitney U tests.

Results: MGO‐treated collagen did not affect cell viability or apoptosis. In addition, MGO did not induce significant changes in morphology or mechanical properties of the collagen matrix. However, MGO‐treated collagen stimulated an increase in the myofibroblast marker α‐SMA, production and assembly of FN, and contraction of collagen matrices. Moreover, use of a triple‐helical peptide that reconstitutes the collagen‐binding domain for integrins GFOGER reverted the assembly of FN induced by MGO‐treated collagen.

Conclusions: The present study shows that collagen glycation by MGO stimulates differentiation of myofibroblasts and production and assembly of FN. These responses may alter the homeostatic balance and wound‐healing response of gingival connective tissues affected by diabetes mellitus or aging.
Periodontal Referral Patterns in Australia: 2000 Versus 2015
Authors: Brown Leah M. , Bowman Patrick , O’Rourke Vincent J. , Mercado Faustino , Marshall Roderick , Parsons Scott
Published: May 2017

Background: A previous study investigated differences in the severity of periodontal disease on referral for specialist care between 1980 and 2000 across the United States. The present study finds patients referred in 2000 had greater severity of periodontal disease than those referred 20 years ago.

Methods: A retrospective analysis of 384 charts was completed from three periodontal practices across the east coast of Australia. Two time periods were investigated: 2000 to 2001 and 2015 to 2016. From these charts, the following data were recorded: 1) age; 2) sex; 3) smoking status; 4) number of missing teeth; and 5) number of teeth planned for extraction as part of a treatment plan at initial examination. Additionally, degree of periodontal severity was determined and recorded. The classification system was based on that used by the previous study, wherein case Types I to IV defined increasing severity of periodontal disease, and Type V defined referrals for needs other than periodontal disease (e.g., crown lengthening and implants).

Results: Overall, patients seen in 2015 presented with a greater percentage of Type IV and Type V cases. Smoking prevalence reduced significantly across the three locations between the two time periods. No consistent or noteworthy trends were identified with regard to number of missing teeth or number of teeth planned for extraction.

Conclusions: Consistent with the results of a similar previous study, there appears to be a trend for more severe periodontal conditions being referred to periodontists. This is concerning given that more severe periodontal conditions tend to be more difficult to manage conservatively and reliably.
Aves ribereñas de los ecosistemas costeros de Tuxpan, Veracruz, México
Authors: Argüelles-Jiménez Jimmy
Published: May 2017

Los ambientes ribereños costeros son una fuente de alimento y refugio para una gran diversidad de aves. Por lo anterior, el presente estudio tuvo como objetivo determinar la diversidad, vulnerabilidad, hábitat, estacionalidad y conectividad de aves en cinco ambientes ribereños de Tuxpan, Veracruz. De diciembre de 2012 a octubre de 2014 se realizaron 912 transectos de 1 km de largo y 100 m de ancho en la ribera del río Tuxpan, la laguna de Tampamachoco, los esteros de Tumilco y Jácome, y en la línea costera. La identi cación de las especies, vulnerabilidad, hábitat y estacionalidad se obtuvo de la literatura especializada; la conectividad se estableció por medio de la diversidad alfa, el índice de Whitaker y análisis de correspondencia canónico (ACC). Se identi caron 15 órdenes, 42 familias, 108 géneros y 150 especies. Por la diversidad destacan los órdenes Passeriformes (43 %), Charadriiformes (18 %) y Pelecaniformes (9 %); de las especies registradas dos se categorizan en peligro de extinción, dos como amenazadas y ocho en protección especial. Por la riqueza especi ca las aves terrestres (59.9 %) son más importantes que las costeras (19.7 %) y marinas (20.4 %). Con relación a la estacionalidad se presentan más residentes reproductivos (43.4 %) que visitantes invernales (33.6 %) y transeúntes (19.7 %). El ACC indica un 60 % de especies compartidas, por lo que el índice de Whitaker fue de 2.45. Los patrones de distribución e interconectividad detectados pueden utilizarse para elaborar planes de manejo y conservación de los ecosistemas costeros de Tuxpan, Veracruz.
Biomasa aérea de Vochysia guatemalensis en una selva alta perennifolia de La Chinantla, Oaxaca
Authors: Manzano-Méndez Filemón , Pineda-Herrera Elizandro , Valdez-Hernández Juan Ignacio , López-López Miguel Ángel
Published: May 2017

Se estimó la biomasa aérea de Vochysia guatemalensis Donn. Smith., una especie de importancia ecológica y económica en el sur-sureste de México. Se derribaron siete árboles de cuatro categorías diamétricas (10, 15, 20 y 25 cm), para luego separarlos por componente estructural. De cada componente se obtuvieron muestras que se pesaron en fresco y se secaron en estufa. Con estos datos se estableció el peso seco para estimar la biomasa por componente y árbol total en cada categoría, ajustando ecuaciones alométricas mediante técnicas de regresión no lineal. Los valores de biomasa aérea por árbol uctuaron de 8.264 a 105.099 kg en fustes, de 0.329 a 21.442 kg en ramas y de 0.393 a 9.609 kg en follaje. A nivel de árbol 79.68 % de la biomasa se encontró en fustes, 13.58 % en ramas y 6.72 % en follaje.
Big-Data-Based Thermal Runaway Prognosis of Battery Systems for Electric Vehicles
Authors: Hong Jichao , Wang Zhenpo , Liu Peng
Published: May 2017

This paper presents a thermal runaway prognosis scheme based on the big-data platform and entropy method for battery systems in electric vehicles. It can simultaneously realize the diagnosis and prognosis of thermal runaway caused by the temperature fault through monitoring battery temperature during vehicular operations. A vast quantity of real-time voltage monitoring data was collected in the National Service and Management Center for Electric Vehicles (NSMC-EV) in Beijing to verify the effectiveness of the presented method. The results show that the proposed method can accurately forecast both the time and location of the temperature fault within battery packs. Furthermore, a temperature security management strategy for thermal runaway is proposed on the basis of the Z-score approach and the abnormity coefficient is set to make real-time precaution of temperature abnormity.
Analysis of the Aerodynamic and Structural Performance of a Cooling Fan with Morphing Blade
Authors: Suman Alessio , Fortini Annalisa , Aldi Nicola , Pinelli Michele , Merlin Mattia
Published: May 2017

The concept of smart morphing blades, which can control themselves to reduce or eliminate the need for active control systems, is a highly attractive solution in blade technology. In this paper an innovative passive control system based on Shape Memory Alloys (SMAs) is proposed. On the basis of previous thermal and shape characterization of a single morphing blade for a heavy-duty automotive cooling axial fan, this study deals with the numerical analysis of the aerodynamic loads acting on the fan. By coupling CFD and FEM approaches it is possible to analyze the actual blade shape resulting from both the aerodynamic and centrifugal loads. The numerical results indicate that the polymeric blade structure ensures proper resistance and enables shape variation due to the action of the SMA strips.
Walking across rural-urban fringe: the hindering effect of intersections
Authors: Blecic Ivan , Congiu Tanja , Canu Dario , Fancello Giovanna
Published: May 2017

The study investigates the influence of road intersections on pedestrian accessibility in urban-rural fringe areas. An evaluation method to support planners and decision makers in the classification of crossing areas according to their effect on walking and in the prioritization of improvement interventions is proposed. In these peripheral parts of towns, pedestrians are almost ignored and people depend on car use for any necessity. Initiatives to improve livability can include the design of walkable friendly environments aiming at offering potential users good levels of security, comfort and convenience when walking to destinations. These spatial requirements have to be provided along road segments and even more on crossing areas which represent sensitive points of the entire connection system with a hindering influence on people’s propensity to walk. Starting with spatial basic interventions aiming at enhancing the continuity, safety and quality of pedestrian paths it is possible to reduce the physical and perceptual distance which separates fringe contexts from the rest of the city leading to a progressive integration of urban functions.
An Amyloidogenic Sequence at the N-Terminus of the Androgen Receptor Impacts Polyglutamine Aggregation
Authors: Oppong Emmanuel , Stier Gunter , Gaal Miriam , Seeger Rebecca , Stoeck Melanie , Delsuc Marc-André , Cato Andrew C. B. , Kieffer Bruno
Published: May 2017

The human androgen receptor (AR) is a ligand inducible transcription factor harboring an amino terminal domain (AR-NTD) hosting the ligand independent activation function. AR-NTD is intrinsically disordered and display aggregation properties conferred by the presence of a poly-glutamine (polyQ) sequence of 22 residues. The length of the polyQ sequence, as well as the presence of adjacent sequence motifs modulate this aggregation property. AR-NTD contains also a conserved sequence motif KELCKAVSVSM that displays an intrinsic property to form amyloid fibrils under mild oxidative conditions of its conserved cysteine residue. As peptide sequences with intrinsic ability to oligomerize are reported to have an impact on the aggregation of polyQ tract, we determined the effect of the KELCKAVSVSM on the polyQ stretch in the context of the AR NTD, using Atomic Force Microscopy (AFM). Here, we present evidence for a crosstalk between the amyloidogenic properties of the KELCKAVSVSM motif and the polyQ stretch at the AR NTD.
Aberrant DNA Methylation in Cholangiocarcinoma
Authors: Nakaoka Toshiaki , Saito Yoshimasa , Saito Hidetsugu
Published: May 2017

Cholangiocarcinoma is an epithelial malignancy arising in the region between the intrahepatic bile ducts and the ampulla of Vater at the distal end of the common bile duct. The effect of current chemotherapy regimens against cholangiocarcinoma is limited, and the prognosis of patients with cholangiocarcinoma is poor. Aberrant DNA methylation and histone modification induce silencing of tumor suppressor genes and chromosomal instability during carcinogenesis. Studies have shown that the tumor suppressor genes and microRNAs (miRNAs) including MLH1, p14, p16, DAPK, miR-370 and miR-376c are frequently methylated in cholangiocarcinoma. Silencing of these tumor suppressor genes and miRNAs plays critical roles in the initiation and progression of cholangiocarcinoma. In addition, recent studies have demonstrated that DNA methylation inhibitors induce expression of endogenous retroviruses and exert the anti-tumor effect of via an anti-viral immune response. Aberrant DNA methylation of tumor suppressor genes and miRNAs could be a powerful biomarker for diagnosis and treatment of cholangiocarcinoma. Epigenetic therapy with DNA methylation inhibitors hold considerable promise for the treatment of cholangiocarcinoma through re-activation of tumor suppressor genes and miRNAs as well as induction of an anti-viral immune response.
Cold Centering Algorithm on Pipe Based on Laser Measurement
Authors: Li Yongbo ,   School of Automation, China University of Geosciences, Yin Xiandong , Liu Weiling , Liu Yafeng , Gou Weihan , Cheng Kuan ,   HuBei Xin Ye Gang Steel Co., Ltd.
Published: May 2017

In view of the present pipe cold-centering processing system, the present situation of the low degree of automation and the deviation from the center position, this research intends to design a kind of tube billet cold-centering processing system based on laser measurement. The system adopts a movable, high-precision laser displacement sensor to the tubular billet’s outer contour, scanning to get the billet cylindrical contour coordinates, and uses the nonlinear numerical filtering least-square-circle fitting method to get the tube billet’s center coordinates. The research results show that the system has a high degree of integrated automation, and the measuring error is less than 0.1 mm when the transition is made to automation. At present, this system has been successfully applied to production, and it successfully realizes tube billet cold centering online processing.
Design of a New Lower-Limb Rehabilitation Machine
Authors: She Jinhua ,   Graduate School of Bionics, Computer and Media Sciences, Tokyo University of Technology, Wu Fajian , Mita Toshihiro , Hashimoto Hiroshi , Wu Min , Iliyasu Abdullah M. ,   School of Automation, China University of Geosciences,   Hubei Key Laboratory of Advanced Control and Intelligent Automation for Complex Systems,   Master Program of Innovation for Design & Engineering, Advanced Institute of Industrial Technology,   Electrical Engineering Department, College of Engineering, Prince Sattam Bin Abdulaziz University
Published: May 2017

Commercially available rehabilitation machines are bisymmetric, and the structure of the machines is fixed. Consequently, they cannot meet various requirements for lower-limb rehabilitation, and people have to adapt themselves to the machines to do exercises. To solve this problem, this paper presents a new kind of rehabilitation machine for the lower limbs. It is left-right asymmetric, and the structure and load of the machine can easily be adjusted to suit different requirements for lower limbs. A prototype of a half model of the machine for one leg is designed and built, and some results of preliminary tests are presented.
A Chronic Disease Diet Recommendation System Based on Domain Ontology and Decision Tree
Authors: Chen Rung-Ching ,   Department of Information Management, Chaoyang University of Technology, Huang Chung-Yi , Ting Yu-Hsien ,   Library, Chienkuo Technology University
Published: May 2017

As society develops and science and technology improve, people have come to care more about a healthy diet. Diet types have gradually changed and focused more on health management. Taiwan is becoming an aging society in which individuals have irregular lifestyles, long-term unhealthy diets, stressful work, and chronic diseases such as diabetes, hypertension, and high cholesterol. However, most dietary recommendation systems cannot give dietary recommendations for patients with chronic diseases. Though healthy foods are recommended, the systems contain little information on whether nutrients are in balance. Therefore, this study constructed a diet recommendation system for chronic diseases using expert knowledge, which enables more convenient and precise dietary recommendations for chronic diseases. In this study, we use an ontology, decision trees, and Jena to construct the recommendation system. The dietary recommendations results are evaluated by dietitians, and the verification accuracy is 100%. Therefore, this system of dietary recommendations can provide convenient, healthy, dietary recommendations for nutrients for patients with chronic diseases.
Analysis of Control Method for Magnetic Bearing Systems
Authors: Huang Gang ,   College of Traffic Engineering, Hunan University of Technology, Yang Xiaolin , She Jinhua , Cao Weihua , Zhang Changfan ,   Beijing BeTech Co., Ltd.,   School of Computer Science, Tokyo University of Technology,   School of Automation, China University of Geosciences
Published: May 2017

Magnetic bearing systems have attracted extensive attention in the fields of high speed, spotless area, vacuum space, etc. System performance depends largely on the control link, and it has become a research focus to improve controller performance to ensure high precision stable suspension and high anti-interference capability. This paper considers optimized, sliding mode, robust, fuzzy, and neural network control systems and assesses their research status and limitations for magnetic bearing systems. Algorithms for proposed vibration and high speed flexible rotor controls are illustrated. Finally, development trends for control technology of magnetic bearing systems are discussed.
Study on Psychological Effect of Cyclic Foot Joint Exercise as a Light Exercise for Sitting Position
Authors: Hosono Minako ,   Human Informatics Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Ino Shuichi
Published: May 2017

We present the physical and psychological effects of a foot joint exercise in a sitting position, as a preliminary experiment to design a foot exercise system for motivating sedentary adults to increase level of their physical activity. The experiment was conducted with four healthy adults performing a cyclic foot joint dorsiflexion exercise in a sitting position. Apart from changes in the blood flow and pulse rate during exercise, affective valence and perceived exertion after exercise were measured. The results indicated that the foot joint dorsiflexion exercise is a low intensity exercise, which does not lead to a change in pulse rate compared to a state of rest. However, the participants’ affective valence and perceived exertion exhibited extensive inter-individual variability. This finding suggests that the foot exercise system need to be designed to account for the possibility of significant individual variations in pleasant/unpleasant emotions, even in the context of light exercise that requires little physical burden.
STRENGTHENING BHINNEKA TUNGGAL IKA AS AN IDENTITY AND UNIFIER OF THE NATION: REALIZING A PEACEFUL ISLAM AND STATEHOOD HARMONIZATION
Authors: Baihaki Egi Sukma
Published: May 2017

The development of the word and the rise of acts such as the destruction of worship houses disputes between religious communities and the acts of terrorism can harm the social order that has been well tied by Bhinneka Tunggal Ika. Thus, understanding about “Bhinneka Tunggal Ika” is an important thing to be concerned and maintained by all elements of the nation. Because the diversity that has existed in Indonesia is a noble heritage deposited by the predecessors to be continued and maintained. Strengthening Bhinneka Tunggal Ika will be needed to reinforce the identity of Indonesia, and become a unifying media for any different faction to unite and to create the peaceful, secure, and prosperous life.
STRENGTHENING OF INDONESIAN ISLAMIC CHARACTER THOUGH ISLAMIC EDUCATION MANAGEMENT BASED OF SOFT SKILLS
Authors: Utaminingsih Sri , Utomo Slamet , Zamroni Edris
Published: May 2017

Symptoms of intolerance that was done by most of the ummah of Islam in Indonesia lately, shows that globalization has brought the ideology of the new that actually erode the identity of Islam Indonesia were very accommodating and tolerant of the wealth of local culture, upholding the values of diversity and emancipatory on the role of women in everyday life. Islamic educational institutions should play a role in the reconstruction of intolerance symptoms that Appeared lately. Through management soft skills-based Islamic education is expected to restore Islam Indonesia on Islam very famous identity steeped in local culture and uphold the values of diversity. This article reviews how the management arrangement soft skills-based Islamic education is Able to restore Islam Indonesia returned to his identity.
Firearm-Related Laws in All 50 US States, 1991–2016
Authors: Siegel Michael , Pahn Molly , Xuan Ziming , Ross Craig S. , Galea Sandro , Kalesan Bindu , Fleegler Eric , Goss Kristin A.
Published: May 2017

Objectives. To describe a new database containing detailed annual information on firearm-related laws in place in each of the 50 US states from 1991 to 2016 and to summarize key trends in firearm-related laws during this time period.

Methods. Using Thomson Reuters Westlaw data to access historical state statutes and session laws, we developed a database indicating the presence or absence of each of 133 provisions of firearm laws in each state over the 26-year period. These provisions covered 14 aspects of state policies, including regulation of the process by which firearm transfers take place, ammunition, firearm possession, firearm storage, firearm trafficking, and liability of firearm manufacturers.

Results. An examination of trends in state firearm laws via this database revealed that although the number of laws nearly doubled during the study period, there was substantial heterogeneity across states, leading to a widening disparity in the number of firearm laws.

Conclusions. This database can help advance firearm policy research by providing 26 years of comprehensive policy data that will allow longitudinal panel study designs that minimize the limitations present in many previous studies.
Effect of the Affordable Care Act on Disparities in Breastfeeding: The Case of Maine
Authors: Hawkins Summer Sherburne , Noble Alice , Baum Christopher F.
Published: May 2017

Objectives. To evaluate the Affordable Care Act (ACA) breastfeeding provision and test whether changes in coverage affected women differently according to health insurance status.

Methods. We used the All-Payer Claims Database from Maine (2012–2014) to compare health insurance claims for lactation classes and breast pumps between women with private insurance and women with Medicaid (1) before the ACA breastfeeding provision, (2) after the provision came into effect, and (3) after health insurance expansion through the Marketplace.

Results. We found limited change in claims for lactation classes over the study period. By contrast, the number of claims for breast pumps among women with private insurance increased from 70 claims in the third quarter of 2012 to 629 claims 1 year later and 803 claims in the third quarter of 2014. Women with Medicaid had only 11 claims for breast pumps over the entire study period.

Conclusions. This 11-fold rise in claims for breast pumps by women with private insurance suggests that these women will likely increase breastfeeding initiation or duration; however, without additional support for women with Medicaid, disparities in breastfeeding may increase.
Chemical Risk Assessment: Traditional vs Public Health Perspectives
Authors: Gwinn Maureen R. , Axelrad Daniel A. , Bahadori Tina , Bussard David , Cascio Wayne E. , Deener Kacee , Dix David , Thomas Russell S. , Kavlock Robert J. , Burke Thomas A.
Published: May 2017

Preventing adverse health effects of environmental chemical exposure is fundamental to protecting individual and public health. When done efficiently and properly, chemical risk assessment enables risk management actions that minimize the incidence and effects of environmentally induced diseases related to chemical exposure. However, traditional chemical risk assessment is faced with multiple challenges with respect to predicting and preventing disease in human populations, and epidemiological studies increasingly report observations of adverse health effects at exposure levels predicted from animal studies to be safe for humans. This discordance reinforces concerns about the adequacy of contemporary risk assessment practices for protecting public health.

It is becoming clear that to protect public health more effectively, future risk assessments will need to use the full range of available data, draw on innovative methods to integrate diverse data streams, and consider health endpoints that also reflect the range of subtle effects and morbidities observed in human populations.

Considering these factors, there is a need to reframe chemical risk assessment to be more clearly aligned with the public health goal of minimizing environmental exposures associated with disease.
Minimum Stocking Requirements for Retailers in the Special Supplemental Nutrition Program for Women, Infants, and Children: Disparities Across US States
Authors: Pelletier Jennifer E. , Schreiber Liana R. N. , Laska Melissa N.
Published: May 2017

Objectives. To examine state variation in minimum stocking requirements for Special Supplemental Nutrition Program for Women, Infants, and Children (WIC)–authorized small food retailers.

Methods. We obtained minimum stocking requirements for 50 states and the District of Columbia in 2017 from WIC Web pages or e-mail from the state WIC agency. We developed a coding protocol to compare minimum quantities and varieties required for 12 food and beverage categories. We calculated the median, range, and interquartile range for each measure.

Results. Nearly all states set minimum varieties and quantities of fruits and vegetables, 100% juice, whole grain–rich foods, breakfast cereal, milk, cheese, eggs, legumes, and peanut butter. Fewer states set requirements for canned fish, yogurt, and tofu. Most measures had a large range in minimum requirements (e.g., $8–$100 of fruits and vegetables, 60–144 oz of breakfast cereal).

Conclusions. WIC-participating retailers must adhere to very different minimum stocking requirements across states, which may result in disparities in food and beverage products available to WIC recipients.

Public Health Implications. The results provide benchmarks that can inform new local, state, and federal program and policy efforts to increase healthy food availability in retail settings.