bluuebunny/crossref_metadata_2025 huggingface dataset:
Two Sustained Release Membranes Used in Formulating Low Strength
Testosterone Reservoir Transdermal Patches
Authors: Vashishth Ria , Chuong Monica C. , Duarte Juan Chang , Gharat Yadnya , Kerr Stephen G.
Published: March 2023

Introduction:

Several Testosterone Replacement Therapies exist for hypogonadism, but an
in-depth analysis of these products reveals a high dosing frequency and a high drug loading, up to 120
mg for a potent drug like Testosterone. This may lead to patient non-compliance and toxicity problems
if used improperly. Androderm® is the only 24-hour marketed transdermal patch. Testopel pellets are
another extended-release product given subcutaneously every 3-6 months. But it requires surgical implantation
and is associated with severe adverse effects. For this reason, the development of other extended-
release testosterone products is needed. The study aims at using different excipients for the exploration
of sustained-release patches.

Methods:

Reservoir formulations were prepared using Carbomer 941 and HPMC K100M as the sustained-
release polymers plus CoTran™ 9702 and CoTran™ 9712 as the release membranes. The formulated
patches were subjected to in vitro dissolution for 24 h. The amount of drug release at each time
point was determined using the developed HPLC assay. FDA Similarity Factor, f2, t-test, and ANOVA
were applied to all nine-point collected samples.

Results:

CoTran™ 9712 membrane was found to be a better candidate than CoTran™ 9702. The
in vitro release profiles of the four formulations were compared (Carbomer vs. HPMC, and CoTran™
9702 vs. CoTran™ 9712).

Conclusion:

CoTran™ 9702 releases testosterone significantly lower. Carbomer and CoTran™ 9712
were the best formulation among all with the highest drug release of 2.16 ± 0.36 mg.
LINC00461 Knockdown Enhances the Effect of Ixazomib in Multiple Myeloma Cells
Authors: Deng Mingyang , Yuan Huan , Peng Hongling , Liu Sufang , Xiao Xiang , Wang Zhihua , Zhang Guangsen , Xiao Han
Published: March 2023

Background:

LINC00461 has been implicated to be involved in several types of cancer while its roles in multiple myeloma remain unclear. Our study aims to investigate the roles of LINC00461 in multiple myeloma and explore its effects on ixazomib therapy.

Methods:

LINC00461 and small nuclear ribonucleoprotein polypeptide (SNRP) B2 knockdown stable cell lines were constructed. Cell viability assays including MTT, cell number counting, and colony formation were performed. RNA-pull down and immunoblotting assays were conducted to determine the intramolecular interactions. qRT-PCR and western blotting were conducted to determine the levels of target genes. Kaplan-Meier analysis was used to evaluate overall survival rates.

Results:

Knockdown of LINC00461 or SNRPB2 enhanced ixazomib's cytotoxicity, as well as affected its regulatory effects on cell apoptosis and cell cycle distribution. Further results showed that LINC00461 knockdown reduced the expression levels of SNRPB2 by their interactions. Additionally, a positive correlation between LINC00461 and SNRPB2 was found in patients with multiple myeloma. Low expression of SNRPB2 was associated with a high survival rate in patients with multiple myeloma.

Conclusion:

Knockdown of LINC00461 enhanced the therapeutic effects of ixazomib against multiple myeloma in part by the regulation of SNRPB2
Emerging Promise of Therapeutic Approaches Targeting Mitochondria in
Neurodegenerative Disorders
Authors: Rahman Md. Mominur , Tumpa Mst. Afroza Alam , Rahaman Md. Saidur , Islam Fahadul , Sutradhar Popy Rani , Ahmed Muniruddin , Alghamdi Badrah S. , Hafeez Abdul , Alexiou Athanasios , Perveen Asma , Ashraf Ghulam Md.
Published: March 2023

Mitochondria are critical for homeostasis and metabolism in all cellular eukaryotes. Brain
mitochondria are the primary source of fuel that supports many brain functions, including intracellular
energy supply, cellular calcium regulation, regulation of limited cellular oxidative capacity, and control
of cell death. Much evidence suggests that mitochondria play a central role in neurodegenerative
disorders (NDDs) such as Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and amyotrophic
lateral sclerosis. Ongoing studies of NDDs have revealed that mitochondrial pathology is
mainly found in inherited or irregular NDDs and is thought to be associated with the pathophysiological
cycle of these disorders. Typical mitochondrial disturbances in NDDs include increased free radical
production, decreased ATP synthesis, alterations in mitochondrial permeability, and mitochondrial
DNA damage. The main objective of this review is to highlight the basic mitochondrial problems that
occur in NDDs and discuss the use mitochondrial drugs, especially mitochondrial antioxidants, mitochondrial
permeability transition blockade, and mitochondrial gene therapy, for the treatment and control
of NDDs.
Monoclonal CCR5 Antibody: A Promising Therapy for HIV
Authors: Lai Yu , Zhao Li
Published: March 2023

HIV is one of the world's most devastating viral infections and has claimed tens of millions
of lives worldwide since it was first identified in the 1980s. There is no cure for HIV infection. However,
with tremendous progress in HIV diagnosis, prevention, and treatment, HIV has become a manageable
chronic health disease. CCR5 is an important coreceptor used by HIV to infect target cells,
and genetic deficiency of the chemokine receptor CCR5 confers a significant degree of protection
against HIV infection. In addition, since CCR5 deficiency does not appear to cause any adverse
health effects, targeting this coreceptor is a promising strategy for the treatment and prevention of
HIV. Monoclonal antibodies are frequently used as therapeutics for many diseases and therefore are
being used as a potential therapy for HIV-1 infection. This review reports on CCR5 antibody research
in detail and describes the role and advantages of CCR5 antibodies in HIV prevention or treatment,
introduces several main CCR5 antibodies, and discusses the future strategy of antibody-conjugated
nanoparticles including the potential challenges. CCR5 antibodies may be a novel therapy for treating
HIV infection effectively and could overcome the limitations of the currently available options.
Saraca asoca: From Traditional Herb to Modern Drug as a Cure for Various
Diseases
Authors: Fathima Faiza , Parveen Rabea , Khan Mohammad Aasif , Malik Zoya , Mustafa Saad , Massey Sheersh , Ahmad Sayeed , Husain Syed Akhtar
Published: March 2023

Background:

Saraca asoca (Ashoka, family; Caesalpiniaceae) is an indigenous sacred tree,
native to India. It has been used in various traditional medicinal systems and is one such plant that is
highly therapeutic but its use in disease management is underrated in today’s era and has lost its importance.

Objective:

This narrative review is written to provide the information on medicinal importance of S.
asoca and the significance of S. asoca in various traditional medicinal systems.

Methods:

Different databases were searched to gather information. Research articles, abstracts, and
reviews are included in this review.

Results:

Saraca asoca is known for its unique pharmacological role in treating various uterine complications,
menstrual disorders, and bacterial infections, bleeding hemorrhoids, urinary and dermatological
problems. The stem bark of the tree is the principal constituent for treating menorrhagia and
genito-urinary disorders. The stem bark, leaves, and seeds of S. asoca are known to contain flavonoids,
tannins, alkaloids, glycosides, polyphenolics, fatty acids, and saponins. The reported major phytoconstituents
responsible for its therapeutic uses are epicatechin, procyanidin B2, lyoniside, nudiposide,
catechin, leucocyanidin, and leucopelargonidin. Various pharmacological activities of this plant
are discussed in this review.

Conclusion:

It has been proved that Saraca asoca possesses several pharmacological properties and is
useful in treating various diseases. More studies on quality control, standardization, and clinical trials
on S. asoca should be performed, so that this plant could be utilized as an effective anti-cancer drug
which could be a promising source for the herbal and pharmaceutical industry.
Sulfonic Acid Functionalized Precipitated Silica as Efficient Solid Acid
Catalyst for Acetylation Reactions
Authors: Chaskar Manohar G. , Ghosh Anirban , Lolage Mayura
Published: March 2023

Introduction:

Precipitated Silica has very high commercial significance in terms of ease of preparation, market volume, cost benefits and a wide range of industrial applications. The surface silanol groups of Precipitated Silica can be modified with reactive organic functional groups to achieve desired properties for specific applications, including catalysis.

Objective::

The objective of this study is to demonstrate sulfonic acid functionalized Precipitated Silica as
a true heterogeneous catalyst in acetylation reaction, where the catalytic activity and desired product selectivity
is a magnitude higher than industrial solid acid zeolite catalysts as well as similar catalysts reported
in literature.

Methods:

A novel and cost-effective method for the functionalization of Precipitated Silica with sulfonic acid (–SO3H) is reported, where the silica nanoparticles are first functionalized in situ with a tetrasulfide organosilane, followed by oxidation of the tetrasulfide moiety to –SO3H groups, which are grafted to the surface silanol groups through covalent linkage.

Results:

CHNS analyses and XPS prove successful functionalization of –SO3H group onto the nano silica surface. The resultant material acts as a solid acid catalyst and shows exceptional activity in the acetylation of benzyl alcohol and >99% selectivity towards the desired product benzyl acetate. The resultant material can also be recycled and reused several times.

Conclusion:

The following factors make sulfonic acid functionalized Precipitated Silica a new generation of solid acid catalyst; (i) higher atom economy, (ii) recyclability and reusability, and (iii) significant cost benefits with respect to industrial catalysts.
Anxiety, Depression and Quality of Life Among Parents
Attending School Counseling Programs: Are they Effected by
Sociodemographic Characteristics?
Authors: Theofilou Paraskevi , Tafarli Georgia
Published: March 2023

Parental stress and depression are factors that significantly affect the exercise of the
parental role and have an impact on the upbringing of children and their quality of life. The
purpose of this study is to investigate the differences between the dependent variables of quality
of life, anxiety and depression in relation to the demographic characteristics, as an independent
variable, in the entire sample before the implementation of parent counseling. A sample of
160 parents was collected to participate. The psychometric tools have been used are: The
Spielberger Stress Trait Anxiety Inventory (STAI), the Beck depression Inventory (BDI), and
the Health and well-being Questionnaire (The RAND 36-Item Healthy Survey, SF-36, Version
1.0). It was found that men have better quality of life in both physical and emotional health,
lower anxiety and depression. A positive correlation between age and emotional health was
found. Younger parents have more anxiety, depression and generally poorer emotional health
than older parents.
Satisfaction with Work–Life Balance during the COVID-19 Pandemic for Full-Time Workers Forced to Work from Home
Authors: Mathis Christopher J. , Anthony Erica L. , Sharif Monica M.
Published: March 2023

The global pandemic caused by Coronavirus disease of 2019 (COVID-19) severely disrupted people’s professional and personal lives making many employees required to work from home. Our study examines family-supportive supervisory behaviors (FSSB) impact on in-role behaviors through satisfaction with work–life balance and psychological availability at work to gain insight into the effects of the pandemic on work and home domains. Based on three waves of data and a sample of 179 full-time employees (32+ hours per week) forced to work 100% at home because of the pandemic, the findings suggest satisfaction with work–life balance and psychological availability at work serially mediated the relationship between FSSBs and in-role behaviors. Also, satisfaction with work–life balance mediated the relationship between FSSB and psychological availability at work, and psychological availability at work mediated the relationship between satisfaction with work–life balance and in-role behaviors. Practical and theoretical implications, along with future research, are discussed.
Productores orgánicos urbanos evaluados con la metodología MuSIASEM para mejorar los agroecosistemas desde la sostenibilidad
Authors: Toledo Lucía , Hernández Dayana , Moncayo Pablo , Viteri Salazar Oswaldo
Published: March 2023

La agricultura sostenible busca imitar los ecosistemas naturales y ser, a la vez, económica y socialmente viable, por lo que es necesario contar con indicadores de sostenibilidad que puedan servir como herramientas de información para conocer las consecuencias ambientales del desarrollo. En este sentido, el análisis integrado multiescala de la sociedad (MuSIASEM) es un marco analítico que permite un análisis de sostenibilidad cuantitativo, multicriterio y multiescala. Bajo este contexto, el objetivo de esta investigación fue evaluar el perfil metabólico social de los productores orgánicos certificados de Agrupar-Conquito mediante este marco. Para esta finalidad, se aplicó un cuestionario estructurado aplicado a una muestra estadísticamente representativa y, como principal resultado, se obtuvo la caracterización biofísica de los productores, a partir sus medios de vida sostenibles, considerando cinco capitales, donde como actividad generadora de ingresos, el capital económico se encuentra en el sector primario; respecto al capital físico, los productores poseen una infraestructura adecuada para la producción de huertos urbanos y bioferias para la comercialización; acerca del capital natural, el 48 % de unidades de producción posee una superficie entre 200 y 500 m2 y el 88 % participa del sistema de agricultura familiar; en cuanto al capital humano, el 85 % son mujeres entre 38 y 65 años; finalmente, en el capital social, el 100 % asiste a actividades asociativas. Los indicadores calculados en los ecosistemas productivos permiten un análisis de los tomadores de decisiones respecto a la generación de políticas y esfuerzos hacia la sostenibilidad.
Deep Learning to Detect Pancreatic Cystic Lesions on Abdominal Computed Tomography Scans: Development and Validation Study
Authors: Duh Maria Montserrat , Torra-Ferrer Neus , Riera-Marín Meritxell , Cumelles Dídac , Rodríguez-Comas Júlia , García López Javier , Fernández Planas Mª Teresa
Published: March 2023

Background

Pancreatic cystic lesions (PCLs) are frequent and underreported incidental findings on computed tomography (CT) scans and can evolve to pancreatic cancer—the most lethal cancer, with less than 5 months of life expectancy.

Objective

The aim of this study was to develop and validate an artificial deep neural network (attention gate U-Net, also named “AGNet”) for automated detection of PCLs. This kind of technology can help radiologists to cope with an increasing demand of cross-sectional imaging tests and increase the number of PCLs incidentally detected, thus increasing the early detection of pancreatic cancer.

Methods

We adapted and evaluated an algorithm based on an attention gate U-Net architecture for automated detection of PCL on CTs. A total of 335 abdominal CTs with PCLs and control cases were manually segmented in 3D by 2 radiologists with over 10 years of experience in consensus with a board-certified radiologist specialized in abdominal radiology. This information was used to train a neural network for segmentation followed by a postprocessing pipeline that filtered the results of the network and applied some physical constraints, such as the expected position of the pancreas, to minimize the number of false positives.

Results

Of 335 studies included in this study, 297 had a PCL, including serous cystadenoma, intraductal pseudopapillary mucinous neoplasia, mucinous cystic neoplasm, and pseudocysts . The Shannon Index of the chosen data set was 0.991 with an evenness of 0.902. The mean sensitivity obtained in the detection of these lesions was 93.1% (SD 0.1%), and the specificity was 81.8% (SD 0.1%).

Conclusions

This study shows a good performance of an automated artificial deep neural network in the detection of PCL on both noncontrast- and contrast-enhanced abdominal CT scans.
The Provision of Texture-Modified Foods in Long-term Care Facilities by Health Professionals: Protocol for a Scoping Review
Authors: Sari Dianis Wulan , Aurizki Gading Ekapuja , Indarwati Retno , Farapti Farapti , Rekawati Etty , Takaoka Manami
Published: March 2023

Background

Malnutrition among older adults with dysphagia is common. Texture-modified foods (TMFs) are an essential part of dysphagia management. In long-term care (LTC) facilities, health professionals have implemented TMFs, but their application has not been fully elucidated, making them heterogeneous.

Objective

We aim to explore the implementation of TMFs in LTC facilities, particularly focusing on the role of health professionals in nutritional care involving TMFs (eg, deciding the type of food, preparing and giving the food, and evaluating the outcomes).

Methods

A scoping review using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) methodological approach will be performed. A comprehensive search for published literature will be systematically performed in PubMed, CINAHL, MEDLINE, ProQuest, PsycINFO, and Science Citation Index (Web of Science). Data screening and extraction will be performed by 2 reviewers independently. The studies included will be synthesized, summarized, and reported, following the preferred reporting items of the Mixed Methods Appraisal Tool. Our review will consider the following study designs: mixed methods, quantitative, and qualitative. Studies with patients who are not older adults will be excluded.

Results

Data extraction will be completed by February 2023. Data presentation and analyses will be completed by April 2023, and the final outcomes will be completed by June 2023. The study findings will be published in a peer-reviewed journal.

Conclusions

Our scoping review will consider studies related to TMF interventions for older adults in LTC residential facilities, with no exclusion restrictions based on country, gender, or comorbidities. Studies on interventions that address TMF-related issues, such as deciding the type of food, preparing and giving the food, and evaluating the outcomes, are qualified for inclusion.

Trial Registration

OSF Registries 79AFZ; https://osf.io/79afz

International Registered Report Identifier (IRRID)

PRR1-10.2196/44201
Use of machine learning techniques for phenotyping ischemic stroke instead of the rule-based methods: A nationwide population-based study (Preprint)
Authors: Lim Hyunsun , Park Youngmin , Hong Jung Hwa , Seo Kwon-Duk
Published: March 2023

BACKGROUND

In South Korea, many studies have evaluated stroke using claims data; most of these studies have defined ischemic stroke by using an operational definition following the rule-based method, assigning the I63 diagnosis code for admission, and incorporating the imaging or drug claims data. Rule-based methods tend to overestimate the number of patients with ischemic stroke.

OBJECTIVE

We aimed to identify an appropriate algorithm for phenotyping stroke by applying machine learning (ML) techniques to analyze the claims data.

METHODS

We obtained the data from the Korean National Health Insurance Service database, which is linked to the National Health Insurance Ilsan Hospital database (n=30,897). The ML techniques were constructed based on the results of a previous chart review (gold standard), and the demographic variables such as qualifications, examination/screening, medical utilization, and total medical costs were used as features. The performance of prediction models (extreme gradient boosting [XGBoost] or long short-term memory [LSTM]) was evaluated using the area under the receiver operating characteristic curve (AUROC), the area under precision-recall curve (AUPRC), and calibration curve.

RESULTS

In total, 30,897 patients were enrolled in this study, 3,145 of whom (10.18%) had ischemic stroke. XGBoost, a tree-based ML technique, had the AUROC was 93.63% and AUPRC was 64.05%. LSTM, such as neural network based deep learning methods, showed results similar to those of the rule-based method. The F1 score was 70.01%, while the AUROC was 97.10% and AUPRC was 85.70%, which was the highest.

CONCLUSIONS

We proposed recurrent neural network based deep learning techniques to improve stroke phenotyping. We anticipate the ability to produce rapid and accurate results by utilizing the National Health Information Database.
How can technology be used to support communication in palliative care beyond the covid-19 pandemic: A mixed-methods national survey of palliative care healthcare professionals (Preprint)
Authors: Stanley Sarah , Finucane Anne , Thompson Anthony , Nwosu Amara Callistus
Published: March 2023

BACKGROUND

Developments in digital health have the potential to create new opportunities for healthcare professionals support delivery of palliative care. Globally, many palliative care professionals used digital health innovations, to support communication with staff, patients and caregivers, during COVID-19 pandemic. However, there is limited data about the views of palliative care professionals of using digital health to support communication during the pandemic.

OBJECTIVE

We aimed to describe how palliative care professionals used technology to support communication (multidisciplinary team working, education and with patients and family caregivers) during the COVID-19 pandemic.

METHODS

UK based palliative care healthcare professionals completed an electronic questionnaire to describe their use of digital health, during the COVID-19 pandemic, to support (1) communication within the multidisciplinary team (MDT), (2) education and (3) to support communication with patients and carers.

RESULTS

Two hundred and thirty-four palliative care professionals participated. Most (n= 227, 97%) described an increase in their use of digital health, to support communication, since the start of the COVID-19 pandemic. We identified benefits and challenges for digital health communication, which we summarised into themes to identify facilitators and barriers for future use of this technology in practice.

CONCLUSIONS

Since the pandemic, palliative care professionals have increased their use of digital health to support communication in clinical practice. We have identified facilitators and barriers for future practice. Further work should identify the levels of support needed for organisations to ensure that digital health interventions are meaningfully used to help palliative care professionals effectively communicate with patients, caregivers and staff.

CLINICALTRIAL

NA
An Investigation on Student Perspectives on Online Learning
Authors: Mision Miguel
Published: March 2023

While there was a short reprieve with the Corona Virus in 2021, the new Omicron strain could potentially rewind the clock back to 2019. What important lessons were learnt in these past two years, and are there benefits to online learning beyond virus prevention? The author examined perspectives and experiences on what it was like learning remotely as a university student. Surveys and one on one interviews were conducted on a target demographic of students. The research had surprisingly mixed results both positive and negative. When asked which style of learning students preferred, there was a three-way split between online, face-to-face, and a blend of both. Although many students and teachers are quick to assume that face-to-face learning allows young people to enjoy a more “normal” university life – the results indicate that there are cases where learning online should have serious consideration.
A PROSPECTIVE OBSERVATIONAL STUDY OF PREDICTORS OF POOR OUTCOMES IN PATIENTS WITH CEREBRAL SINUS VENOUS THROMBOSIS AT A TERTIARY CARE CENTER IN INDIA
Authors: S SUHANA , N RAVAL
Published: March 2023

Objective: The objective of this study was to evaluate the factors associated with poor outcome in cerebral sinus venous thrombosis (CSVT) patients at 3 and 6 months.
Methods: This was a prospective observational study in which CSVT patients hospitalized at a tertiary care center in Davangere, India during November 2016–October 2018 were included and followed up for 6 months. CSVT diagnosis was confirmed with imaging findings of computed tomography, magnetic resonance imaging, and magnetic resonance venography. Modified Rankin Scale score of 0–1 was considered indicative of “good outcome,” while that of ≥2 indicated “poor outcome.”
Results: Data of 44 patients were collected, of which 59% (n=26) were male, 68.2% of the patients belonged to the age group 25–45 years (mean age: 34.91±11.23 years). Fifteen patients (34.09%) had acute, 24 patients (54.55%) had sub-acute, and five patients (11.36%) had chronic symptom duration. At 3 months, age >45 years (p=0.008), focal seizure (p<0.001), hemiparesis (p<0.001), cerebellar signs (p<0.008), infarct (p=0.006), hemorrhage (p=0.049), edema (p=0.012) and midline shift (p=0.007), involvements of straight sinus (p=0.035), inferior sagittal sinus (p=0.007), frontal lobe (p=0.038), and Glasgow coma scale (GCS) score of 8–12 (p=0.008) were significantly associated with “poor outcome.” At 6 months, patients with focal seizures (p=0.001), hemiparesis (p=0.008), hemorrhage (p=0.044), midline shift (p=0.013), involvement of parietal lobe (p=0.025), presence of hemorrhage (p=0.044), and GCS score of 8–12 (p=0.001) significantly higher rate of “poor outcome.”
Conclusion: This real-world observational study identifies the clinicodemographic and neuroimaging variables significantly associated with “poor outcome” in CSVT patients.
NON-DESCENT VAGINAL HYSTERECTOMY USING BIPOLAR VESSEL SEALING SYSTEM VERSUS TOTAL LAPAROSCOPIC HYSTERECTOMY FOR BENIGN DISEASES OF UTERUS: A PROSPECTIVE INTERVENTIONAL STUDY
Authors: SINGH SUNDER PAL , MANGLA DIVYA , KUMAR VIPIN
Published: March 2023

Objective: The objective of the study was to compare the surgical outcomes of non-descent vaginal hysterectomy (NDVH) using bipolar vessel sealing system and total laparoscopic hysterectomy (TLH) with reference to intraoperative time, intraoperative blood loss, and post-operative pain. Methods: The study was conducted on 100 patients who required hysterectomy for benign diseases of uterus and was fit to undergo both modalities of surgery (TLH/NDVH). 50 patients that underwent TLH and 50 patients that underwent NDVH with BipBIPVSS were part of Study Group. Results: The mean intraoperative time taken in performing NDVH using Bipolar BIPVSS (28.06 min) was significantly less than the mean time taken in performing TLH (92.62 min). The intraoperative blood loss in NDVH with BIPVSS was 41.70 mL and TLH was 89.24 mL. The post-operative pain in both the study group was not statistically significant as both the groups had similar experience and p>0.05. Post-operative major complication of bleeding in ovarian artery and hemoperitoneum was observed in a patient of NDVH with BIPVSS while one case of thermal rectal injury and one case of bladder injury were observed in TLH group. Conclusion: The route and procedure of hysterectomy will depend on various factors; however, NDVH with BIPVSS has certain advantage over TLH as it takes lesser times, lesser blood loss and gives similar pain experience if not better than TLH.
STUDY OF PERFORMANCE CHARACTERISTICS OF TSH ON FINECARE™ POCT DEVICE
Authors: KAUR JASPREET , SINGH MITHILESH KUMAR , SAMADHIYA AMIT , GUPTA GITANJALI , CHANE RENU , KAUR JASWANT
Published: March 2023

Objective: Thyroid diseases can be diagnosed and monitored by serum thyroid stimulating hormone (TSH) measurement along with serum T3 and T4 (both free and total). However, TSH is used to distinguish between euthyroid and hyperthyroid patients. Hence, analysis sensitivity of the TSH assay plays a very significant role. Aims and objectives – The aim of the study was to perform the precision study, calculate the randomerror and analytical measurement rangeverification, as well as verify the accuracy of TSH estimation on Finecare™ point of care testing (POCT).
Methods: The experimental evaluation was done in preliminary and final parts. The preliminary part calculates random errors, systemic errors, and recovery whereas the final evaluation comprises the implementation of the method comparison between chemiluminescence and immunofluorescence assay (CLIA).
Results: In the preliminary evaluation, the inter-assay-high-value sample had CV% was 15 whereas the low-value sample has 13, and the intra-assay had a CV% of 5.8. The recovery test shows 22.22% CV. The final evaluation of the new method Immuno Fluorescence Assay and reference method (CLIA) has a correlation of coefficient 0.9937.
Conclusion: POCT reduces pre-analytical error by reducing misidentification of the patient, specimen, and sample handling. This reduces the turn-around time. It helps to improve the quality of care, healthy outcomes, and affordability.
EVALUATION OF MICROCYTIC HYPOCHROMIC ANEMIA BY ELECTROPHORESIS FOR HEMOGLOBINOPATHIES IN YOUNG POPULATION
Authors: SINGH UTKARSHA , SAXENA PRIYANKA , BIDWAI ATUL KUMAR , SINGH MADHURIMA
Published: March 2023

Objectives: Hemoglobinopathies are serious genetic blood disorders requiring lifelong blood transfusions and treatment in its most severe and chronic form. If undiagnosed or untreated, these disorders ultimately lead to death. South Asia especially India, Pakistan, and Bangladesh has high populations of hemoglobinopathies. In India, there are an estimated 100,000 thalassemia majors patients and nearly 3.5 to 4 million carriers of this genetic disorder. Tribal populations in India have a range of 5–40% sickle cell anemia (SCA) sufferers. The aim of the study was to detect hemoglobinopathies by electrophoresis in microcytic hypochromic anemia in young population in the area covered by tertiary care center at Index Medical College and Hospital. Methods: A cross-sectional study was carried out in a hospital in rural area of Indore on young patients (10–30 years age group) who attended outpatient department from June 2018 to March 2020. Total 517 cases of moderate to severe anemia were included in the study. All cases were subjected to a series of hematological investigations, which include complete hemogram, peripheral blood smear, and some standard procedures. Sysmex XS800i fully automated Cell counter was used for complete blood count. It is the 5-part differential instrument. It reports on all the five subpopulations, namely, neutrophils, eosinophils, basophils, monocytes, and lymphocytes. A blood smear is a blood test used to look for abnormalities in blood cells. Results: In the study, out of 517 cases 34.4% cases were positive on Hb electrophoresis and 65.6% were negative. On electrophoresis, the number of sickle cell anemia cases was 34.3%, sickle cell trait – 20.8%, sickle beta-thalassemia – 29.8% and beta-thalassemia major – 29.8% was observed. In hemoglobinopathies, of the 73 females, 28.8% were having beta-thalassemia trait, 27.4% were having SCA 23.3% were having sickle beta-thalassemia, and 20.5% were having sickle cell trait. Of the 105 males, 30.5% were having beta-thalassemia trait, 9.5% were having sickle beta-thalassemia, 39.0% were having SCA, and 21.0% were having sickle cell trait. Conclusion: The ANMs, ASHA, and Anganwadis should be taught about the importance of screening of hemoglobinopathies. So that they can explain the purpose of screening to the female during pregnancy and to the families in the rural areas. At primary level, the CHCs and PHCs should be equipped with instruments for basic testing of hemoglobinopathies.
РЫНКУ НУЖНА ОТЕЧЕСТВЕННАЯ ЛИНЕЙКА УНИФИЦИРОВАННЫХ ПРИВОДОВ С ВЫСОКОЙ СТЕПЕНЬЮ ГОТОВНОСТИ К ПОСТАВКЕ
Authors: Гурбашков М.
Published: March 2023

Сложно переоценить значение электроники для нашей жизни. Но для того чтобы она
приносила пользу в реальности, необходимы «мостики» между реальным миром и миром напряжений и токов. Один из таких «мостиков» – приводные системы, и не
удивительно, что эта область техники также переживает подъем. О ситуации в этой области в нашей стране, о путях ее развития и деятельности компании «ИнноДрайв» в этом направлении, об одной из самых перспективных областей применения приводных систем – робототехнике, и ее роли как драйвера отрасли микроэлектроники, а также о том, как робототехника будет представлена
на предстоящей выставке ExpoElectronica, и о новой линейке приводов «Харза»,
которая будет демонстрироваться на данном мероприятии, нам рассказал генеральный директор ООО «ИнноДрайв» Максим Борисович Гурбашков.
ГЛОБАЛИЗАЦИЯ И МОНОПОЛИЗАЦИЯ МИКРОЭЛЕКТРОНИКИ В СОВРЕМЕННЫХ УСЛОВИЯХ
Authors: Шелепин Н.
Published: March 2023

В статье рассмотрено современное состояние производства полупроводников в мире, тенденции и перспективы развития микроэлектронных технологий в различных регионах. Описаны беспрецедентные усилия США по возврату ведущих микроэлектронных производств на свою территорию и меры по противодействию развития технологий в Китае.
НОВИНКА ОТ THINKING ELECTRONIC: КОМБИНИРОВАННЫЕ УСТРОЙСТВА ЗАЩИТЫ ОТ ИЗБЫТОЧНОГО НАПРЯЖЕНИЯ И ТОКА СЕРИИ KRV
Authors: Коротков М.
Published: March 2023

Тайваньская компания Thinking Electronic Industrial предлагает широкую линейку компонентов для защиты цепей от избыточного напряжения, тока и температуры. В статье рассмотрены особенности и преимущества комбинированных устройств защиты серии KRV.
Оценка вероятности регистрации ошибочных символов в канале атмосферной оптической связи на рассеянном излучении в УФ-диапазоне длин волн в условиях дня и ночи
Authors: Тарасенков М.В. , Пешков С.А. , Познахарев Е.С.
Published: March 2023

Рассматривается модель канала атмосферной
оптической связи на рассеянном излучении
в УФ-диапазоне длин волн. Основу модели
составляют алгоритмы метода Монте-Карло
локальной и модифицированной
двойной
локальной оценки для расчета
импульсной реакции канала оптической
связи. Для диапазона длин волн
от 200 до 400 нм в условиях дня и ночи
оценивается вероятность регистрации
ошибочных символов при кодировании
информации временной задержкой между
импульсами. Расчеты показывают, что
длина волны λ = 295 нм будет лучше других
подходить для организации дальней
связи днем, а длина волны λ = 395 нм – для
организации связи ночью с помощью
рассмотренной приемной системы.
Reacciones al estrés y aspectos psicoterapéuticos
Authors: Souza y Machorro Mario
Published: March 2023

The scientific journalism of this article deals with a common exception in the specialized environment about various mental disorders associated with stress and its comorbidity, inadequate confrontation by the patient/family, its genetic-epigenetic condition and the deficient management provided by some health professionals. The disdain of psychotherapeutic management (prejudice- lack of preparation) hinders the adequate attention of cases. It is of the utmost importance to develop proper maternal and filial attachment, adequate measures for the achievement of social mental health and
assistance programs to attend the cases.
Keywords: Mental disorders; stress disorders; adjustment disorders; mixed treatment; psychotherapy"
Relación de los hábitos de estudio y estilos de aprendizaje con el rendimiento académico en estudiantes de propedéutico de Chapingo
Authors: Peña Escalona Fleider Leiser , Victorino Ramírez Liberio , Salinas Martínez Jesús Armando , Gonzalez Garduño Roberto
Published: March 2023

El objetivo del estudio fue relacionar los estilos de aprendizaje (EA) y hábitos de estudios (HE) con el rendimiento académico (RA) de los estudiantes de propedéutico de la Universidad Autónoma Chapingo. Para obtener la información se utilizaron dos instrumentos, el cuestionario de Honey-Alonso de estilos de aprendizaje (CHAEA) y el cuestionario de hábitos y técnicas de estudio (CHTE). El muestreo consideró a 142 estudiantes de propedéutico, de los que se obtuvieron las calificaciones de sus materias cursadas. Las respuestas del cuestionario sobre los HE y de los EA se analizaron mediante la prueba de Kruskal-Wallis y se evaluó la correlación entre las diferentes escalas. Durante el primer semestre, quienes manifestaron tener hábitos moderados tuvieron la menor calificación (77), y los de buenos y excelentes hábitos tuvieron similar calificación (81.5-81.7). Durante el primer semestre los estudiantes con muy altos EA tuvieron la menor calificación (79). En los estudiantes con EA activo no se observó correlación con las calificaciones. Se concluye que la correlación de los hábitos de estudio y los estilos de aprendizaje con el rendimiento académico en estudiantes de propedéutico de la Universidad Autónoma Chapingo fue muy baja y en muchos casos no existió significancia.
Харьцангуйн онол ба их энергийн физик
Authors: M Ц. Баатар , Г. Шархүү
Published: March 2023

Харьцангуйн онол ба их энергийн физик
Ялихгүй "тодотгол"
Authors: Г Очирбат
Published: March 2023

Броуны хөдөлгөөнийг том "молекулийн" хөдөлгөөн гэж үзэж болох уу
Радиофизикийн сургалт, судалгааны хөгжилд профессор Д. Батсуурийн оруулсан хувьд нэмэр
Authors: Э. Дамдинсүрэн
Published: March 2023

Радиофизикийн сургалт, судалгааны хөгжилд профессор Д. Батсуурийн оруулсан хувьд нэмэр
Нарны зуух зохион бүтээх асуудал
Authors: М. Баатархүү  , Ц. Эрдэнэцэцэг  , З. Батмандах
Published: March 2023

Манай улс сэргээгдэх эрчим хүчний асар их нөөц баялагтай билээ. Энэ их эрчим хүчийг өөрийн орны газар зүйн онцлогт тохируулан ашиглах тулгамдсан асуудал бидний өмнө гарч ирж байна. Сэргээгдэх эрчим хүчний нэг төрөл болох нарны эрчим хүчийг парабол толины тусламжтайгаар цуглуулан өндөр температур гарган авч, ахуйн хэрэглээнд ашиглах багажыг зохион бүтээж туршсан болно.
Монгол орны шилний элсний судалгаа
Authors: М. Цэрэнчимэд
Published: March 2023

Abstract: Series of laboratory experiments to melt glass from sand have been completed in Gorkhi pegmatit crystal deposit, Zuun mod deposit, Central province, Altangol, Buirnuur deposit, Dorot province, Boruruu deposit, Sukhbaatar province. The glass and glass properties have been identified jointly with the researchers of the Glass and Ceramics Laboratory BAM, Germany. The investigation of physical properties of sand and glass has been performed applying chemical analysis, liquid gas extraction, ESR study, infrared radiation and dilatometric research using sophisticated equipment and techniques. It is revealed and concluded that sand from all deposits except Zuunmod deposit, Central province can melt transparent, high quality glass.
Сөрөг керр орчинд тарах гэрлийн стационар те долгионы фазууд параметруудаас хамаарах нь
Authors: О. Нямсүрэн  , Г. Очирбат
Published: March 2023

Сөрөг керр орчинд тарах гэрлийн стационар те долгионы фазууд параметруудаас хамаарах нь
Аугаа их эрдэмтэн Альберт Эйнштейн
Authors: Д. Сангаа
Published: March 2023

Аугаа их эрдэмтэн Альберт Эйнштейн
Политехникийн дээд сургуулийн хөгжилд профессор Д. Батсуурын гүйцэтгэсэн үүрэг
Authors: M Ч. Авдай , С. Дашдаваа
Published: March 2023

Политехникийн дээд сургуулийн хөгжилд профессор Д. Батсуурын гүйцэтгэсэн үүрэг
Турмалин кристаллын бүтэц
Authors: Г. Буянцэцэг  , Ш. Мөнхжаргал  , Ч. Баярхүү  , Л. Ням-Очир  , Д. Отгонбаяр
Published: March 2023

Бид энэ ажлаараа турмалин кристаллын 2 дээж авч харьцуулан кристалл бүтцийг рентген бүтцийн аргаар судалсан. Судалгааны үр дүнгээс турмалины кристаллын агуулгыг тодорхойлж бүтцийг дүрслэв. Туршилтаар турмалин кристалл байгаль дээр туйлширсан бүтэцтэй болох нь батлагдав.
Systematical Analysis on angular Distribution of Bremsstrahlung radiation in microtron MT-22
Authors: B. Otgooloi  , N. Enkhbat  , J. Oyunbileg
Published: March 2023

The systematic analysis has been made the measurement results of the relative angular distribution of gamma quantium with 11-22 MeV energy which is induced by bremsstrahlung within 2-3 g/cm optimal geometrical region of target nucleus. We are shown that relative intensity distribution of gamma radiation with energy 11-22 MeV, induced by stopped electrons with various thicknesses at heavy and lighter target nucleus as an exponential form within angular region 0°-14o
Carrier mobility in field effect transistors based on copper-phthalocyanine thin films with different phase structure
Authors: Lkhamsuren Enkhtur , Ragchaa Galbadrakh
Published: March 2023

Using annealing procedure at different temperatures after deposition at room temperature we obtained copper- phthalocyanine (CuPc) thin films with a — and p —phase structure. A phase structure of thin films was controlled by X-ray diffraction method, morphology was controlled by SEM. The field effect transistors was fabricated by high vacuum deposition of CuPc thin film (thickhess of 100 nm) on Si02 substrate which acting as gate contact. Gold drain and source contacts deposited on the top of active layer of FET. From measured current voltage measurements calculated mobility and concentration of charge carriers in FET. These parameters depend on phase structure of CuPc thin film, and characteristics of our FET are comparable with values of other authors.

CuPc is commercially available macro cyclic metal complex that can be easily obtained in large quantity and high purity. Together with other phthalocyanine derivatives, the chemically and thermally stable CuPc has wide applications in dye processing, spectral sensitization, chemical sensors, and optical data storage [3-4]. The semiconducting behavior of metal phthalocyanines was first observed in 1948 and they have since attracted great interest in advancement of protptype organic semiconductors. Among the metal substituted phthalocyanines CuPc has been found superior properties [5-7], such as phenomena of field dependent and wavelength-dependent efficiency in an organic static induction transistors, and stabilizing role of CuPc layer on a highly stable organic electroluminescent device based on thin film Alq, and indicated a very weak interaction between CuPc and Au at the interface.

In general, phthalocyanine materials can exist in several crystalline polymorphs, including a-, p -, x-and y - structure, and the most well known are the thermally metastable a- and p - [8-10], Phthalocyanine films deposited at room temperature usually consist of a-phase crystallites (at sublimation pressure of less than 10 Pa). At higher deposition pressures or at substrate temperature above 210°C, the p -phase directly obtained [11], Although it is well known that a-phase crystallites undergo a phase transformation into P -phase by treatment in various organic suspension media [12,13] or during annealing at higher temperatures [14,15], only some authors describe the nature of the a—>p phase transformation of copper phthalocyanine thin films with a thickness of less than 100 nm [8,14-15].
Фуллереиы и Фулериты В Полимерной и Керамической Матрицах
Authors: С. А. Жданок  , Шпилевский Э. М , Шилагарди Г. , Цоохүү Х. , Ragchaa Galbadrakh , Lkhamsuren Enkhtur , Jigmeddorj Vanchinkhuu
Published: March 2023

Фуллереиы и Фулериты В Полимерной и Керамической Матрицах
Физический метод определения магнитной постоянной
Authors: M Л. Дэмбэрэл , Г. Шилагарди
Published: March 2023

Здесь был обработан один физический метод определения магнитной постоянной , имеющей значение, равное 4п-10"7Гн/м. Затем метод был проверен на эксперименте, физический основ которого лежит на взаимодейсвии между магнитным полем соленоида и катушкой слабого тока. В результате этого эксперимента было определено значение магнитной постоянной, близкое к справочному данному.
Хэт авиа ба гидродинамик кавитацийн багаж төхөөрөмж, уураг, гормоны сонохемилюминесценци
Authors: Р Хоролжав , Б Магсар , Э Амарзаяа , Т Бадамхатан , Г Сүхбаатар
Published: March 2023

Пьезокерамик үүсгүүр бүхий сонолюминометр, гидродинамик кавитацийн үүсгүүрийн хэд хэдэн шинэ хувилбаруудыг зохион бүтээж, хэт авианы кавитацийн нөлөөгөөр шингэнд үүсэх чөлөөт радикалын гинжин урвалын өдөөгдсөн завсрын бүтээгдэхүүн идэвхээ алдахдаа (дезактивация) сонохемилюминесценци үүсгэдгийг амин хүчил, пептид, уураг, гормоны усан уусмалд туршилтаар илрүүлж, судалсан үр дүнгээс энд өгүүлнэ.
Rare earth mining and consumption global trends and mining perspectives for the Mushugay Khudug deposit in southern Mongolia
Authors: R Galbadrakh , K Simon , T Myanganbaatar , L Nyam-Ochir , N Tuvjargal , Ts Myanganbayar , J Davaasambuu , G Woerner
Published: March 2023

In this work the 3 ore body drill core samples. 6 host rock samples from the main ore body of the Mushugay Khudug REE deposit in southern Mongolia were selected as most representative samples and studied by XRD and ICP-MS. LA-ICP-MS method to evaluate elemental and structural composition data of the deposit. According to our determinations the main orebody of the Mushugay Khuduk deposit contain up to 130 kg/ton of REEs. Despite the moderate total mineable reserve the main ore body of the Mushugay Khuduk deposit might compete economically with world's biggest REE mining deposits such as Bayan-Obo (Inner Mongolia. China) or Mountain Pass (California. USA) if consider the deposit's higher REE grade and easier to mine local geological condition. The important advantage of the Mushugay Khuduk deposit is that the relative contents of most valuable HREEs Eu. Tb. Dy. and Lu are significantly higher than that of Mountain Pass or Rayan-Obo. The relative net content of these four elements is 0.1% for Mountain Pass and 0.4% for Bayan-Obo. while the ore samples of the Mushugay Khuduk deposit has 0.75% according to our determinations.
ИССЛЕДОВАНИЕ ПАРАМЕТРОВ ЭЛЕМЕНТА ХОЛЛА С КОНЦЕНТРАТОРАМИ МАГНИТНОГО ПОТОКА КАК ЧЕТЫРЕХПОЛЮСНИКA
Authors: Г Шилагарди , В.А Ярмолович , В.И Прокошин , Х Цооху , Р Нямдулам , Д Тимурбаатар
Published: March 2023

Энэ ажилд сул соронзон оронг хэмжихийн тулд хэрэглэгдэх ферросоронзон материалаар үйлдсэн соронзон өтгөрүүлэгчийг зохион бүтээх оптималь горимыг (к = В*/В) олж тогтоох онолын үндсийг боловсруулжээ.
Фуллеренээр чанаржуулсан зэс нимгэн хальсны тензоцахилгаан чанар ба түүний эсэргүүцэл давтамжаас хамаарах
Authors: К.В Добрего , Ц Хандмаа , Э.М Шпилевский , М.Э Шпилевский , И.И Васильев , Г Шилагарди , Д Төмөрбаатар , Х Цоохүү , Д Эрдэнэбаатар , Р Нямдулам
Published: March 2023

Сопротивление тонкой медной пленки, модифицированной фуллеренами возрастает при увеличение массой доли фуллерена в композите и в широкой области частот переменного тока имеет индуктивный характер.
Металл фуллерены нимгэн хальсны физик чанарт хэмжээсийн үзэгдлийн үзүүлэх нөлөө
Authors: К.В Добрего , Ц Хандмаа , Э.М Шпилевский , М.Э Шпилевский , И.И Васильев , Г Шилагарди , Д Төмөрбаатар , Х Цоохүү , Д Эрдэнэбаатар , Р Нямдулам
Published: March 2023

Было показано, что тензочувствительности тонкой металлической пленки, допированной фуллеренами на один порядок выше чем исходной металлической пленки и по мере уменыиения толщины возрастает.
Фуллеренээр чанаржуулсан титаны нимгэн хальсны тензоцахилгаан чанар ба түүний эсэргүүцэл давтамжаас хамаарах нь
Authors: К.В Добрего , Ц Хандмаа , Э.М Шпилевский , М.Э Шпилевский , И.И Васильев , Г Шилагарди , Д Төмөрбаатар , Х Цоохүү , Д Эрдэнэбаатар , Р Нямдулам
Published: March 2023

В работе было показано, что величина тензочувствительности γ   тонкой пленки титана, допираванной фуллеренами повышается при увеличении массой доли фуллерена, а также соправтавление пленки в переменном токе имеет емкостный характер.
Соронзон орон хэмжигч магнитометр-1
Authors: Д Төмөрбаатар , Г Шилагарди , Х Цоохүү , В.А Ярмолович , В.И Прокошин , А.П Драпезо , Р Нямдулам , С Мөнхцэцэг , Б Чулуунбаатар
Published: March 2023

Был конструирован малогабритный магнитометр на основе холловского датчика КД ФТТ7.003.00.000 выпущенного в пропзводственним объединением института твердого тела и полупроводники Республики Беларуси, который в состаянии измерить магнитного поля в зазоре размера 1,140,34111мм3