bluuebunny/crossref_metadata_2025 huggingface dataset:
Erros na administração de inaladores em pacientes pediátricos com asma
Authors: Honorato Pedro Fechine , Silva Jaqueline Alessandra Castro da , Miranda Amanda Ferreira , Evangelista Kássia Monicléia Oliveira , Santos Alex Cruz dos , Ferreira Silvio Cesar de Albuquerque , Neves Rafael Vieira , Lima Edne Wanessa Nóbrega Crispim , Rocha João Marcos Rodrigues , Teixeira Pedro Henrique Moura
Published: September 2024

A asma é uma das doenças crônicas mais comuns na infância, afetando aproximadamente 20% das crianças no Brasil. O tratamento eficaz da asma depende da correta administração de medicamentos por via inalatória, com diferentes dispositivos disponíveis. No entanto, o uso inadequado desses dispositivos contribui para o controle insatisfatório da doença. Este estudo realizou uma revisão integrativa da literatura dos últimos 10 anos para identificar os principais erros cometidos por crianças asmáticas no uso de aerossóis dosimetrados, além de discutir estratégias para reduzir esses erros e otimizar o tratamento. A pesquisa foi realizada em bases de dados com os termos "inhaler", "technique", "asthma" e "errors", resultando na seleção de 16 artigos. Os erros mais comuns foram não esperar 30 segundos a 1 minuto entre as doses e a ausência de expiração completa antes da inalação. Erros menos frequentes incluíram a ativação múltipla do dispositivo, falhas na coordenação entre a ativação e a inalação, e vedação inadequada do espaçador ou máscara. Esses erros comprometem a eficácia do tratamento e o controle da asma, sendo fundamental corrigi-los para melhorar os resultados terapêuticos na pediatria.
THE CREATIVE LEGACY OF THE ACADEMY FULL MEMBER I.D. KOVAL’CHENKO (TO THE 100th ANNIVERSARY OF HIS BIRTH)
Authors: Abramova Nadezhda Grigorievna
Published: September 2024

. Th e Faculty of History at Lomonosov Moscow State University recently celebrated the 100th anniversary of the birth of Ivan Dmitrievich
Koval’chenko (1923–1995), a distinguished full member of the Academy whose
pioneering work has profoundly infl uenced the fi eld of historical science. Recognized internationally, his contributions continue to shape the discipline. Th is centennial milestone was marked by a series of commemorative events, including a
scientifi c conference, an exhibition of books and materials, and a display of photographs and documents. Th e seventh memorial conference, held on 28 November
2023, addressed contemporary issues in historical science, with themes refl ecting
the scientifi c problems initiated and developed by Koval’chenko. His students,
colleagues, and emerging researchers honored him through their speeches and
reports, emphasizing his signifi cant contributions to the development of historical
methodology, source studies, historiography, and the introduction of quantitative methods in historical research. Th e conference underscored the importance
of identifying classes of mass historical sources and evaluating the application
of modern information theory in source studies. Participants shared personal
memories of Koval’chenko as a scholar, professor, and heroic participant in the
Great Patriotic War. Discussions focused on the current state and future prospects
of the research areas Koval’chenko championed throughout his career, the impact
of his scientifi c school on contemporary historical science, and the formation and
professional training of young historians. His leadership in defi ning the tasks and
directions of the Department of Source Studies at the Faculty of History, as well
as his role in establishing a laboratory for the application of electronic machines in historical research — later transformed into the Department of Historical Informatics — was also highlighted.
Investigative Forensic ToolKit Usage and Determinants of Adoption Behavior among Police Personnel
Authors: Nirban Virendra , Mishra Umesh
Published: September 2024

Technology has become integral to personal and professional spheres in the last two decades. There has been an unprecedented and rapid innovation in technology artifacts and their use for development and empowerment. Similarly, technology has been a part of governance for a long time. The basic objective of this paper is to understand the technology adoption behavior of police personnel in Rajasthan, India, and to identify factors that determine the technology adoption behavior of police personnel. The study's goals are not only to advance theory on the relationship between technology and policing but also a) to understand the technology adoption behavior of police personnel in Rajasthan, India, and b) to identify factors that determine the technology adoption behavior of the police personnel. In pursuit of the above goals, the focus was mainly on technologies significant for policing. For this study, the Forensic Toolkit has been taken as the technology artifact. The quantitative method has been used in the study for data collection. Descriptive and Inferential statistics have been used in the paper for analysis.
QUALITY GUIDELINES FOR CHILDCARE FOR CHILDREN UNDER 3 YEARS OF AGE – A COMPARATIVE ANALYSIS OF SELECTED EUROPEAN UNION COUNTRIES
Authors: Sowa-Kofta Agnieszka
Published: September 2024

The purpose of the presented article is to compare the guidelines for providing high quality education and care for the youngest children (up to age 3) in selected European countries: Sweden, the Netherlands and the Czech Republic. The analysis is based on desk-research referring to the scientific literature, legal regulations, methodological materials (manuals for caregivers) and national and international reports on the organization of early childhood education and care. The international comparison points to several priority areas in establishing early education and care regarding educational norms and values, methods of working with children that provide opportunities for individual cognitive, social and emotional development, methods of ensuring cooperation between institutions of care with caregivers or with institutions of the education system, and ensuring adequate social participation.
EARLY CHILDHOOD CARE AND PARENT’S WORKING TIME FLEXIBILITY
Authors: Lipowska Katarzyna , Magda Iga
Published: September 2024

We analyzed the relationship between flexible working time and the use of care services for children under three years of age. We used data from the EU-LFS ad hoc module in 2018 for twelve European countries. We model the probability of using a nursery using logistic regression. We include flexible working hours, other characteristics of the workplace, and demographic controls as independent variables. We hypothesized that the use of nursery care and flexible working time are positively correlated, strengthening each other’s impact on the ability to combine work and family life. This was not reflected in the data. Parents who chose their working hours were more likely to use nurseries only in Belgium and France. There was no correlation between nursery use and flexible working time in the remaining countries. People with high education were more likely to use nurseries in almost all countries, as were younger people in France, people living in cities in Italy and Poland, and people working part-time in Austria. Younger people in Austria, the Netherlands, and Great Britain, those employed on a fixed-term basis in France, and those working part-time in Spain and Ireland used nurseries less often. Our study contributes to the literature on working time flexibility in testing the joint functioning of this work-life balance instrument with the use of nurseries.
THE PERSONAL BUDGET AS AN INSTRUMENT FOR THE TRANSFORMATION AND DEVELOPMENT OF SOCIAL SERVICES FOR PEOPLE WITH DISABILITIES. FROM WORLDWIDE CONCEPTUAL ASSUMPTIONS TO POLISH IMPLEMENTATION PROPOSALS
Authors: Głąb Zbigniew
Published: September 2024

The main aim of the article is to introduce the concept of a personal budget (PB) for people with disabilities to a wider academic discussion in Poland. The article is based on an analysis of the literature on the subject and of foreign solutions as well as Polish proposals that have emerged recently as part of the operationalisation of the UN Convention on the Rights of Persons with Disabilities.The key issue is the ideological basis of the PB and the resulting construction of the instrument. These are based on the postulate of a shift from creating social services in a 'system-centred approach' to a 'person-centred approach'. The nature of PB makes it have the potential to build a balance between these approaches.The article also contains preliminary remarks and discussion directions concerning the possibility of implementation and the role of PB as an instrument of social policy in Poland supporting persons with disabilities. It also presents the advantages and disadvantages of the instrument and possible implementation difficulties for its users, organisers and providers of social services.
THE GLOBAL PANDEMIC OF YOUTH'S ADDICTION AND ITS SOCIO-ECONOMIC BURDEN
Authors: Żółtaszek Agata
Published: September 2024

Addictions are a set of hazardous mental illnesses that are often neglected in everyday life and healthcare policies. Young people are particularly vulnerable to addictive substances and behaviours due to biological aspects of brain development as well as economic, technological, social and cultural advances. Numerous studies confirm the fast-rising prevalence of abuse and addiction among youth has achieved the pandemic level. Moreover, the lifelong burden of addiction is exceptionally cumbersome for children, adolescents and young adults because costs tend to accumulate over extended period with elevated risk of comorbidity and complications in future life. Therefore, this study attempts to assess both the morbidity of addiction among young people and the related socio-economic burden. The research was carried out by a literature review and statistical analysis. The results indicate that the problem of youth addiction is severe and systematically growing. In particular, the prevalence of online behavioural dependencies is rising, while the healthcare systems are not prepared for the drastic change.
MicroRNAs in the progression of atherosclerosis: rise and fall of the atherosclerotic plaque
Authors: Rampin Andrea , Mutoli Martina , Martelli Massimiliano , Settembrini Alberto M. , Martelli Fabio , Mitić Tijana , Sopić Miron , Bruno Antonino , Spinetti Gaia , CA AtheroNET COST Action
Published: September 2024

Atherosclerosis is the main cause of mortality globally, being at the basis of most cardiovascular diseases. It is a multifactorial disease, arising from complex interactions comprising changes in lipid metabolism, inflammation and oxidative stress. These factors contribute to endothelial damage and dysfunction, the accumulation of immune cells and smooth muscle cells in the intima, ultimately leading to the formation of atherosclerotic plaques, which restricts blood flow through the vessels. Much progress has been made in the last decades in debunking the underlying mechanisms of atherosclerosis development, especially concerning the evaluation and prediction of plaque stability and the understanding of the roles played by each of the involved cell types. As yet, mechanisms that drive plaque development toward specific 'vulnerable' phenotypes remain undiscovered. Based on recent advancements in RNA therapeutics, this review aims to illustrate a comprehensive overview of miRNAs relevant to various aspects of atherosclerosis and emphasizes their theranostic potential, highlighting their dual role as both drug targets and biomarkers.
Atherosclerosis and cholesterol: What we should know
Authors: Catapano Alberico L.
Published: September 2024

The relationship between plasma cholesterol levels and the risk of cardiovascular events is well known. When analysing plasma cholesterol levels and integrating data from several studies, including the Pooling Project, the Framingham Heart Study and the Israeli Perspective Study, a consistent association was confirmed worldwide. This pattern was particularly evident in the Seven Countries Study.1 The observed variations in risk across different populations are largely due to the baseline risk values of these populations. For example, the Framingham Heart Study has shown that its results are applicable in any country by adjusting for baseline risk, suggesting a universal pattern in the relationship between cholesterol levels and cardiovascular risk. This has led to debate because the relationship has been oversimplified and presented as linear when it is not necessarily so. For example, an increase in total cholesterol of 0.5 mmol/L (about 20 mg/dL) correlates with a 12% change in mortality risk. In agreement with this observation, data from the Cholesterol Treatment Trialists' (CTT) Collaboration have shown that lowering low-density lipoprotein cholesterol (LDL-C) by 1 mmol/L reduces the risk of coronary heart disease by 22-23% reduction, which is consistent with data from clinical trials.
Novel approaches to lipid lowering
Authors: Averna Maurizio
Published: September 2024

The focus of this review are the novel and future approaches to reduce the cardiovascular (CV) residual risk by reducing the apoB-containing lipoproteins levels. We assume that in the clinical practice a combination therapy based on the use of high intensity statins, ezetimibe, bempedoic acid, mAbs anti PCSK9 or Inclisiran may reduce most of the cardiovascular risk associated with the apoB containing lipoproteins and may contribute to achieve the LDL-Cholesterol (LDL-C) goal in the majority of individuals at high and very high risk. However we can assume that a proportion of well treated patients will develop new cardiovascular events. Many factors such as the genetic background, the pre-existing burden of disease and the residual risk attributable to triglycerides, inflammation, coagulation and platelets may explain this recurrence of events. We discuss some novel options to reduce the residual risk due to the two main apoB-containing lipoproteins, LDL-C and Lp(a), that are: -the newest-generation CETP inhibitor, Obicetrapib; the oral PCSK9 inhibition; the novel approaches to reduce Lp(a) plasma levels (antisense oligonucleotides-ASO; rna interfering-Sirna; assembly inhibition-; the PCSK9 gene editing.
Transformando a educação: Metodologias ativas, tecnologia e rotação por estações
Authors: Magnago Walaci , Siqueira Nicolas Krugel , Candeia Állan Stieg , Baiôcco Larissa Valfré , da Silva Elbert Iesus Veloso Nery , Pinheiro Rafael Barbosa , Dos Santos Leomar Vanderlei Rodrigues , Pires Helicy Loss , Ramos Aline Marques , Bravim Sabrina Ciríaco Saith
Published: September 2024

A educação contemporânea está passando por uma transformação significativa impulsionada por abordagens pedagógicas inovadoras. Este estudo explora na fundamentação da pesquisa em metodologia de pesquisa bibliográfica, o papel das metodologias ativas como catalisadoras do processo educacional, destacando a participação ativa dos alunos, a colaboração e a aplicação prática do conhecimento como elementos essenciais, onde autores fundamentam a compreensão destas, ressaltando a importância da autonomia do aluno no processo de ensino e aprendizagem. Em outro ponto de análise, a revolução tecnológica também desempenha papel crucial nesse cenário, pois ferramentas digitais e plataformas online enriquecem a experiência educacional permitindo a personalização do aprendizado, a interação entre os alunos e o acesso a recursos diversificados. Dentro desse contexto, exploramos a Rotação por Estações como uma metodologia ativa específica, que emerge como uma estratégia dinâmica para enriquecer o processo educacional. A leitura oferece uma visão desses elementos, destacando o conceito de metodologias ativas, tecnologia atrelada a mesma e a eficácia da Rotação por Estações.
Ciberloafing en el trabajo: un estudio comparativo de las dimensiones de autorregulación según sexo, edad y años de experiencia
Authors: Vargas Vargas Gaby , Castillo Maza Juan Victoriano
Published: September 2024

El objetivo de la investigación fue determinar las diferencias significativas en la percepción del ciberloafing según el sexo, la edad y los años de experiencia en profesionales que participan en un programa de posgrado en Gestión Empresarial. Este estudio se caracterizó por su enfoque aplicado, basado en la aplicación de principios y teorías previamente establecidos para examinar su aplicabilidad en contextos no explorados anteriormente, siguiendo la metodología propuesta por Hernández y Sampieri en 1998. La metodología implementada fue de tipo descriptivo comparativo con un diseño transversal, lo que implicó la recolección de datos en un único momento, según lo descrito por Hernández, Fernández y Bautista en 2010. Las conclusiones del estudio revelaron que existen diferencias significativas en la manifestación del ciberloafing entre los profesionales, las cuales están influenciadas por el sexo, el rango de edad y años de experiencia laboral. Estos hallazgos subrayan la importancia de considerar estas variables al desarrollar estrategias de intervención en el ámbito organizacional.
A Retrospective Review of Morbidity and Mortality in ‘Good Samaritan’ Animals Admitted to a Tertiary Referral Veterinary Health Center From 2014 to 2022: Postmortem Examination
Authors: Jeong Yea Ji , Premanandan Christopher , Her Jiwoong
Published: September 2024

Introduction: Good Samaritan animals are frequently encountered at veterinary teaching hospitals and provide a useful indirect surveillance tool for monitoring major morbidity and mortality in unattended animals.
Methods: Retrospective study. Good Samaritan animals’ medical and postmortem examination records were searched from the OSU VMC medical record database and the OSU CVM Anatomic pathology database and identified 100 cases from 2014 to 2022.
Results: One hundred Good Samaritan animals that underwent postmortem examination were identified. These included 59 cats, 36 dogs, 2 raccoons, 1 squirrel, 1 bat, and 1 opossum with mean and median ages of 2.61 years and 1 year, respectively. The most predominant cause of death or major morbidity requiring euthanasia was euthanasia for rabies test (n = 19) in cats and vehicular trauma (n = 16) in dogs. Other mortality and significant morbidities include trauma (n = 15) followed by infectious disease (n = 5) in cats and infectious disease (n = 12) and neoplasia (n = 2) in dogs. Brain tissue from 51 animals was submitted to the Ohio Department of Health for rabies tests, and all had negative results. In 17 canines and felines with infectious diseases, dogs had viral (n = 6), parasitic (n = 5), and bacterial (n = 1) etiologies, while cats had bacterial (n = 2) and viral (n = 1), fungal (n = 1), and mixed (n = 1) etiologies.
Conclusion: Epidemiological review of morbidity and mortality in Good Samaritan animals submitted for postmortem examination helps to characterize the types and severity of vehicular trauma and infectious diseases in stray animals. Young and intact animals were important demographic factors in Good Samaritan dogs and cats. The rabies test results tightly correlate with a trend of rabies test results in dogs and cats in Franklin County.
The Position Of Paralegals In Providing Legal Assistance To The Defendant Is Guidance In The Trial Based On The Understanding Of The Legal Aid Law No. 16 Of 2011.
Authors: Nafik Ainun , Crismayudhi Helvin , Laksana Aji Indra , Rahman Alip , Dimyati Agus
Published: September 2024

This study examines the position of paralegals in the provision of legal aid in Indonesia, especially in the context of changes regulated by Law Number 16 of 2011 concerning Legal Aid. Prior to this regulation, paralegals were not allowed to handle litigation or non-litigation cases. However, after the regulation is implemented, paralegals are permitted to provide non-litigation legal assistance. The purpose of this study is to analyze the legal position of paralegals in providing legal aid and the factors that influence them in carrying out this role. This research uses a normative juridical method with a descriptive approach based on laws and legal documents. The results of the study show that although the regulation has given authority to paralegals, there still needs to be resistance from various related parties. The main factors that affect this are the need for recognition of paralegals, the limitation of human resources, and the lack of budget and cooperation between legal stakeholders. This study concludes that further clarification is needed regarding the role of paralegals in creating equitable legal justice.
«Still! Wir wollen in eine Seele schauen!»
Authors: Verheyen Jan
Published: September 2024

Sein Leben war ein beständiger Kampf gegen die Welt – gegen deren Gewicht und deren Lärm. Mit seinen Texten versuchte FRANZ KAFKA beidem zu entfliehen. Ein Essay

VON JAN VERHEYEN
Zurück in die Zukunft
Authors: Behrendt Eva
Published: September 2024

Das Staatsschauspiel Dresden startet mit Lessings «Nathan der Weise» und Hendrik Bolz’ «Nullerjahre» in die neue Spielzeit

Von Eva Behrendt
A Method to Categorize and Classify Artificial Intelligence Applicable to the Risk-Based Audit Approach
Authors: Föhr Tassilo L.
Published: September 2024

The technological capabilities of Artificial Intelligence (AI) have significant implications for the auditing profession. Nevertheless, there is no guidance on the use of AI, which is preventing its widespread adoption within the profession. To make use of AI’s functionalities, there is a need for guidance on how AI can be used to gather sufficient and appropriate audit evidence. Thus, utilizing Design Science Research, the present study developed the AI Categorization and Classification (AI-CC) Method as a central artifact to provide guidance on the use of AI within the profession. The target users of the AI-CC Method are regulators, standard setters, the strategic management of the Big Four, and individual auditors. A comprehensive evaluation involving several AI experts across Germany confirmed the overall usefulness of the AI-CC Method for the entire auditing profession.
Obtaining and Assessing Evidence From the Hearing of a Minor Victim under the European Investigation Order – Selected Problematic Issues
Authors: Flis-Świeczkowska Marta , Świeczkowski Dawid
Published: September 2024

The aim of the article is to present selected issues related to the hearing of a minor victim on the basis of the EIO. Conducting this investigative measure, the requirements of which may be strictly defined in national law and at the same time result from protection standards common to EU Member States, may involve additional reservations on the part of the issuing State (Art. 9 para. 2 of the Directive 2014/41). On the other hand, carrying out this activity in accordance with the law of the executing State, but without complying with the formalities and procedures expressly indicated by the issuing authority, constitutes a potential basis for assessing the correctness and admissibility of evidence in the proceedings pending in the issuing State. The authors present the issue of obtaining evidence requiring the hearing of a minor victim from the perspective of EU law and national law, using Polish regulations as an example. On this basis, the authors present conclusions regarding the procedure for the execution of the EIO in a situation where its execution is to be associated with respecting additional conditions stipulated by the authority issuing the order, as well as the assessment of evidence obtained in a procedure that differs from the national law of the issuing State.
Gathering of Evidence by the European Public Prosecutor’s Office In Cross-border Investigations – Some Reflections from a Polish Perspective
Authors: Wąsek-Wiaderek Małgorzata
Published: September 2024

This article concerns the issue of gathering of evidence by the EPPO in cross-border investigations conducted with the participation of Polish procedural organs, with special focus on the search of private premises. The first part of the contribution contains the analysis of the cooperation with the EPPO prior to Poland’s accession to the enhanced cooperation. The second part addresses the potential problems of interpretation and application of Art. 31 of the EPPO Regulation in Poland after joining the EPPO. In particular, the scope of judicial review of the search carried out in Poland by the assisting EDP is analysed as well as the challenges stemming from the first judgment of the CJEU concerning the EPPO Regulation (C-281/22, G.K). The aim of this contribution is to highlight the potential difficulties in carrying out cross-border investigations by the EPPO in the Polish territory and to provide proposals for addressing those difficulties.
Die Komplementarität räumlicher und zeitlicher Aspekte in der Eschatologie des Hebräerbriefes
Authors: Belenkaja Elena
Published: September 2024

The Letter to the Hebrews presents a unique eschatology between space and time embedded in an artful symbiosis of philosophical and theological thoughts, with its author developing his very own eschatology within the New Testament. Its peculiarity is expressed in the interweaving of perfect, present and future statements. Their interpretation suffers from the difficulty of grasping the limitations of these statements and their relationship to each other, a challenge which this book takes up. In an exegetical case study of the primary text (Heb. 1–13), the author examines relevant statements on the understanding of time and space, taking into account their complementary relationship.
Neue Kunst zeigt Themen
Authors: Janhsen Angeli
Published: September 2024

Geld, Zeit oder auch der Klimawandel: Heutige Kunstausstellungen behandeln oft Themen statt großer Namen oder Stilrichtungen. Sie sprechen Betrachter und Betrachterinnen als Einzelne an, ohne klare Botschaften zugeben. Über neue Kunst zu sprechen und zu schreiben, fällt vielen schwer, weil die alten Ordnungen nicht mehr greifen. Begriffe wie Landschaft, Porträt, Aktions- und Performancekunst oder auch ikonografische Traditionen nützen wenig, wenn Francis Alÿs einen Eisblock durch die Straßen schiebt oder Yoko Ono vorschlägt, ein Streichholz anzuzünden. Angeli Janhsen regt dazu an, die eigenen Interessen ernst zu nehmen und assoziativ zu denken: Warum wird ein Thema ausgestellt, was ist ein Thema für mich? Welches Thema interessiert Künstler wie Francis Alÿs oder Yoko Ono? Wie fasse ich ein Thema für eine meiner Arbeiten im Studium? Oder ein Thema für einen Artikel, für ein Buch? Themen klären Inhalte. Anhand zahlreicher Beispiele zeigt die Autorin, wie man sich in der oft zunächst befremdlichen neuen Kunst zurechtfindet.
Aktionelle Gefahrenvorfeldmaßnahmen
Authors: Walker Michael
Published: September 2024

Since 2017, the police – initiated by the Bavarian legislature – have been permitted to take measures such as residence bans and reporting obligations in numerous federal states in the run-up to dangerous situations. This represents a paradigm shift, whose constitutional framework has not yet been clarified and is therefore subject to a fundamental examination. To this end, the common purpose-related differentiation of police action is questioned, a group of cases that justify a deviation from the police law model is identified on the basis of comparable problem situations and the normative scope of the legislature for specific and proportionate legal bases is defined.
Das Freiwilligenprogramm in der arbeitsrechtlichen Restrukturierung
Authors: Spicker Sophie
Published: September 2024

Employers are increasingly turning to so-called Voluntary Leave Programs in order to implement necessary staff reductions with the greatest possible legal certainty. This study examines the implications of the use of Voluntary Leave Programs in terms of Labor Law, Human Resources, Social Law and Tax Law. Based on the nature of the Voluntary Leave Program as an instrument of labor law restructuring practice, the thesis guides the reader through the various phases of restructuring through Voluntary Leave Programs and gives answers to legal and tactical questions involved. It shows that different legal requirements apply depending on the type of the Voluntary Leave Program and the degree of voluntary commitment.
Napoleons Schwiegersohn
Authors: Merkle Hans
Published: September 2024

Wie wird man der Schwiegersohn des mächtigsten Mannes in Europa? Wie lebt man mit einer Frau, die glaubt, einen besseren Ehemann verdient zu haben? Wie oft muss man nachgeben, wenn ein unumschränkter Herrscher Forderungen stellt? Wie kann man seine Haut retten, wenn eine Allianz aller europäischen Mächte den mächtigen Schwiegervater zu Fall bringt? Wie kann man ein aus kleinen und kleinsten Herrschaften bestehendes Land strukturieren und organisieren, damit es regiert werden kann und auch stürmische Zeiten übersteht? Antworten gibt die vorliegende, erste umfassende Lebensbeschreibung des Großherzogs Karl Ludwig Friedrich von Baden. Sie öffnet den Blick auf einen umstrittenen Landesherrn, dem nicht wenige Zeitgenossen die Regierungsfähigkeit absprachen. Manche entschuldigten seine Charaktermängel mit einem Hinweis auf eine missratene Erziehung. Aber – trotz aller berechtigter Kritik an seiner Person – muss man anerkennen, dass er es verstand, sich mit klugen Beratern zu umgeben und auf sie zu hören. Sein bleibendes Verdienst ist es, dem Land Baden die erste freiheitliche Verfassung in Deutschland gegeben zu haben.
Königin in der Fremde
Authors: Borgolte Michael
Published: September 2024

Europa als Kommunikationsgemeinschaft entstand auch durch die Ehen von Königstöchtern mit Herrschern anderer Reiche - ihre Rolle als »Heiratsmigrantinnen« gestalteten die Frauen mitunter sehr selbstbewusst. »Politische« oder »diplomatische« Ehen sind keine mittelalterliche Erfindung, sondern begleiten seit jeher die Weltgeschichte. Fast immer war eine solche Eheschließung verbunden mit dem Umzug der Frauen ins Land des Mannes – nur selten war es umgekehrt. »Europa« als Kommunikationsgemeinschaft meist christlicher Staaten ist auch durch das Netzwerk jener Heiraten entstanden. Dieser Befund ist längst bekannt, die spinnennetzförmigen Beziehungen sind immer wieder nachgezeichnet worden. Erstmalig werden hier jedoch die Anfänge der europäischen Bündnisse zwischen dem 5. und 11. Jahrhundert mit Fokus auf in dieser Zeit geschlossene politische Ehen erzählt. Dabei zeigt Michael Borgolte insbesondere auf, wie die betreffenden Frauen im Rahmen der ihnen zugedachten Rolle agierten. Durch biografische Skizzen wird deutlich, dass die meisten die ihnen gestellte Aufgabe annahmen, andere sich auflehnten, sehr viele aber ihren Status als »Heiratsmigrantin« auch als eine Chance zur Gestaltung des eigenen Lebens nutzten. Diese Option bot sich ihren unverheirateten, in der Heimat zurückgebliebenen oder im Kloster lebenden Schwestern nicht. Nicht zuletzt geht es hier also – mit dem Problembewusstsein unserer Zeit – um den Umgang mit frühmittelalterlichen Migrantinnenschicksalen.
Expeditionen ins Inselmeer
Authors: Juterczenka Sünne
Published: September 2024

Wie entstehen Epochen? Im 18. Jahrhundert prägten Expeditionen in den Pazifik europäisches Geschichtsdenken und das »zweite Entdeckungszeitalter« wurde erfunden. Im Rahmen von Forschungsexpeditionen, die Großbritannien und Frankreich im Zeichen der Aufklärung in die »Südsee« (den Pazifik) entsandten, suchten europäische Reisende im 18. Jahrhundert nach dem Kontinent »Terra australis« und beschrieben Geografie, Natur und Menschen der Region. Mediale Berichterstattung begleitete die Expeditionen; nicht zuletzt wegen der Beteiligung durch deutsche Naturforscher wie Johann Reinhold Forster und seinen Sohn Georg wurden sie auch in der deutschen Presse aufmerksam verfolgt. In der grenzübergreifenden Rezeption der Pazifikforschung, so die These dieses Buches, entstand die Vorstellung von einem »zweiten Entdeckungszeitalter«, das den Höhepunkt einer von Europa ausgehenden, zielstrebigen Erderkundung bildete. Beginnend mit der Konquista im 16. Jahrhundert hatte diese Entwicklung durch wissenschaftliche Neuerungen des 17. Jahrhunderts eine entscheidende Wendung genommen und gipfelte nun in einer neuen Ära, in der europäische Länder friedlich um »Entdeckungen« wetteiferten. Die Untersuchung nutzt so unterschiedliche Quellen wie Zeitungsartikel, Bibliotheksleihregister, Lektüreberichte und Schiffswracks. Neben Spezialisten und Spezialistinnen der Aufklärungsforschung, der Wissens- und der Historiografiegeschichte sowie der Maritime History wird auch ein breites Lesepublikum angesprochen.
Experimentierfeld Versepos (1918-1933)
Authors: Fischer Clara
Published: September 2024

Ein erstmaliger Einblick in die vergessene Versepik der Weimarer Republik. Mit Untersuchungen zu Thomas Mann und Alfred Döblin und einer umfangreichen Bibliografie Das Epos verorten wir in der Antike und im Mittelalter. Aus der Moderne hingegen sind uns lange Erzählungen in Versen praktisch unbekannt – was nicht heißt, dass es sie nicht gibt. In ihrer Studie untersucht Clara Fischer erstmals die deutschsprachige Versepik des Zeitraums 1918-1933. Dabei konzentriert sie sich auf zwei prominente Autoren, deren Versepen im Gegensatz zu ihren Romanen schnell in Vergessenheit gerieten: In Kapiteln zu Thomas Manns »Gesang vom Kindchen« (1919) und Alfred Döblins »Manas« (1927) geht die Autorin den Gründen beider Schriftsteller dafür nach, kurz nach dem Ersten Weltkrieg Erzählungen in Versen zu verfassen. Umfassende historische Einordnungen und detaillierte Textanalysen rücken die zunächst befremdlich wirkenden Dichtungen in ein neues Licht. Wie sich herausstellt, erfüllt das Versepos eine wichtige Funktion in der Romankrise des frühen 20. Jahrhunderts und für das Selbstverständnis zweier Autoren, die einen hohen Anspruch an die literarische Sprache haben. Die Bedeutung dieser außergewöhnlichen Textgattung beschränkt sich dabei nicht auf Mann und Döblin – davon zeugt eine kommentierte Arbeitsbibliographie, die mit über 200 Titeln einen tieferen Einblick in die Versepik der Weimarer Zeit ermöglicht.
Gambaran Religiusitas pada Remaja yang Kecanduan Minuman Keras (Alkohol) di Desa “X”
Authors: Dinar Sulistyaning Kusuma  , Muhimmatul Hasanah  , Awang Setiawan Wicaksono
Published: September 2024

The highest level of alcohol consumption in education is among students. One of the factors causing the increase in alcohol consumption behavior and the rise in crime cases due to alcohol consumption is a lack of religiosity. Religiosity as the internalization of religious values related to belief in religious teachings. These beliefs are then actualized in human behavior. This research is included in the type of qualitative research with a case study approach. The conceptual boundaries of this research are religiosity, teenagers aged 18 - 21 years, and subjects who live in Village "X". The subjects in this research were teenagers who were alcoholics, both male and female, totaling 5 subjects. In this research, nonprobability sampling technique was used with purposive sampling. Subjects have a level of belief in God, religion and sin in their religion. Having high intentions can influence the subject's level of commitment to carrying out ritualistic activities. Subject knowledge regarding religious knowledge is fulfilled through developing digital media. Subjects' feelings towards ritual activities and their experiences of consuming alcohol vary. subject, no one mentioned behaving well because they were motivated by the teachings of their religion. All subjects felt comfortable with the circle of friends that the subjects were now living in. Factors that influence individuals to consume alcohol are environmental factors and the individual's own desires.
Todas las Flores: Una mirada al barrio Santafe desde las Zonas Especial de Alto Impacto (SEZAI) y Actividades Sexuales Pagadas (ASP)
Authors: Rivero Rosanna , Del Rosario Margarita
Published: September 2024

En este ensayo, se discutirán los decretos que establecieron las zonas de alto impacto en el Barrio Santafé de Bogotá, como un intento por lograr una planificación urbana lógica que armonice, legalice y controle las áreas ya establecidas en el barrio, versus la difícil situación que enfrentan los residentes que se desempeñan como trabajadoras sexuales, vista desde el lente de Carmen Oquendo Villar en su documental, “Todas las Flores” (2023).
Educational Thought of K.H. Ahmad Shohibul Wafa Tajul 'Arifin and its Implementation in the Institution Suryalaya Islamic Boarding School
Authors: Wawan Wawan , Mansyur Agus Salim , Tafsir Ahmad , Hasanah Aan
Published: September 2024

KH Ahmad Shohibul Wafa Tajul 'Arifin's (Abah Anom) thoughts on Islamic education have important relevance in the revitalization of education in Indonesia, especially in the aspect of exemplary. This study aims to identify and analyze the implementation of Abah Anom's teachings in shaping student character at Suryalaya Islamic Boarding School and evaluate its impact on Islamic education as a whole. This research uses a descriptive method with an ethnographic model to understand the implementation of education at the Suryalaya Islamic Boarding School. Data were collected through observation and interviews with teachers and students. The implementation of Abah Anom's TQN teachings in Suryalaya succeeded in shaping the character of Muslims who have the quality of dhikr, thought, and charity. The educational approach that prioritizes akhlakul karimah and exemplary habituation by teachers has proven effective in creating a positive learning environment. The results show that education based on exemplary can overcome the decline in the values of formal education. Abah Anom's teachings emphasize the importance of spiritual and moral relationships in education, which can be a solution to achieving national goals in the context of Islamic education in Indonesia.
Ciri Makroskopis dan Mikroskopis Fosil Kayu Asal Desa Manunggal Jaya Kabupaten Kutai Kartanegara
Authors: Febrian Febrian , Husien Nani , Erwin Erwin
Published: September 2024

Penelitian ini bertujuan untuk mengidentifikasi ciri makroskopis dan mikroskopis fosil kayu yang ditemukan di Desa Manunggal Jaya, Kabupaten Kutai Kartanegara, Kalimantan Timur. Studi ini penting dalam konteks geologi dan lingkungan, karena fosil kayu dapat memberikan informasi tentang kondisi ekosistem masa lalu serta perubahan lingkungan. Metode pengamatan makroskopis dilakukan dengan menganalisis warna, mengukur kekerasan, dan menghitung berat jenis fosil kayu, sementara pengamatan mikroskopis dilakukan pada tiga bidang: transversal, tangensial, dan radial, menggunakan mikroskop stereoskopis NIKON SMZ 645 dengan perbesaran 20x dan 30x. Teknik ini dipilih untuk mendapatkan detail struktur sel yang lebih akurat. Kekerasan diukur menggunakan alat uji kekerasan batu "Diamond Selector II," dan berat jenis dihitung dari perbandingan antara berat dan volume bahan. Hasil pengamatan makroskopis menunjukkan bahwa fosil kayu memiliki warna putih, campuran coklat, dan abu-abu, dengan nilai kekerasan 5 skala Mohs dan berat jenis 2.24. Pengamatan mikroskopis mengungkapkan adanya sel pembuluh berbentuk bulat dengan pengelompokkan soliter, porositas tata baur, serta parenkim apotrakeal dan paratrakeal yang jarang. Jari-jari tipe multiseriate heterogen memiliki lebar sel jari-jari 1-3 seri dan terdapat butir silika berbentuk bulat tak beraturan di dalam sel jari-jari. Berdasarkan identifikasi xylarium bogoriense, fosil kayu ini termasuk dalam kategori hard wood yang menyerupai Genus Dipterocarpus dari Family Dipterocarpaceae. Temuan ini memberikan kontribusi dalam pemahaman tentang keanekaragaman hayati serta potensi pemanfaatan fosil kayu dalam penelitian lebih lanjut.
Penyuluhan Tentang Peluang Usaha Baru Melalui Penerapan Digital Marketing bagi Pelaku UMKM Di Desa Pemakuan
Authors: Hasanah Mahmudah , Sari Raihanah , Musfiqah Siti , Norhasanah Lisa , Azkia Nurul
Published: September 2024

Desa Pemakuan, yang berada di Kecamatan Sungai Tabuk, Kabupaten Banjar, Provinsi Kalimantan Selatan, dikenal sebagai penghasil sagu dengan luas wilayah 3,05 km². Produk olahan sagu dari desa ini biasanya dipasarkan secara tradisional di pasar Martapura, Banjarbaru, dan Banjarmasin. Metode penjualan yang terbatas ini menyebabkan produk hanya dikenal oleh pembeli yang datang langsung ke pasar, yang pada akhirnya tidak berdampak signifikan terhadap peningkatan pendapatan UMKM setempat. Meskipun bahan baku sagu melimpah, dibutuhkan inovasi dalam produksi. Salah satu solusi yang ditawarkan adalah pelatihan peluang usaha baru melalui digital marketing untuk membantu UMKM Basamaan di Desa Pemakuan memperluas jangkauan pasar mereka, baik secara online maupun offline, dengan harapan dapat meningkatkan keuntungan. Kegiatan pengabdian ini dilaksanakan secara langsung dengan melibatkan pelaku UMKM Basamaan, di mana mereka dilatih untuk menerapkan digital marketing melalui platform media sosial seperti Whatsapp, Twitter, Instagram, Facebook, dan marketplace, serta membuat video menarik dengan bantuan seorang blogger untuk memperkenalkan produk mereka. Hasil dari kegiatan ini adalah pembuatan website oleh perwakilan masyarakat Desa Pemakuan, yang menampilkan pemasaran produk-produk sagu mereka, baik yang masih mentah maupun yang sudah diolah.
Learning Of The Permissible Perspective In The Bright Of The Structure On Education And Culture Of Timor-Leste (2024)
Authors: Corte-Real de Araújo Alexandre Gentil
Published: September 2024

Introduction: In the constitution article 59.° it is written there that all citizens have the right of access to education, the State must preserve and convert education with dignity, young people do not give importance to school, to the insertion of citizens' participation in education, thus, education is the pillar of the development of society, culture is the identity of one self the country's identity, the number of usages and customs stored by the ancestors in the generation that establish the rules that fit into the values of such a fundamental culture.
DESIGNING CONTROLLED RELEASE FORMULATIONS: EXPLORING DIFFUSION, DISSOLUTION, AND ION EXCHANGE PRINCIPLES FOR DRUG DELIVERY
Authors: Sheoran Reena , Shanno Kumari , Rao Avinash Kumar , Gairola Jagriti
Published: September 2024

System based on controlled drug release had a revolutionized the field like pharmaceuticals by offering precise dosing, improved patient compliance, and of enhanced therapeutic outcomes. This Book delves into the intricate world designing release controlled formulations, that is chiefly focused on the exploration based on diffusion, dissolution, and ion exchange principles as fundamental mechanisms for drug delivery.Our scientific objective is to investigate these mechanisms comprehensively and harness their potential for creating innovative pharmaceutical formulations. We aim to advance the understanding of diffusion, dissolution, and I.E. (Ion exchange) objectives and their applications in the development of novel controlled release systems.This Book will address fundamental questions surrounding these principles, their optimization, and potential synergies between them, opening new avenues for multifunctional drug delivery systems. We will also explore recent advancements and cutting-edge technologies in the realm of controlled release, considering their potential for personalized medicine and improved patient care. In addition to scientific exploration, this study will address the practical challenges and regulatory considerations inherent for the betterment and advancement in the field of released controlled medications and formulations via planting and creating a bridge that fulfill gap between theory and application, our research endeavors to enhance patient compliance, therapeutic efficacy, and the overall quality of pharmaceutical treatments across various medical conditions.Through this comprehensive examination in the form Book about diffusion, dissolution, and ion exchange principles, our study in the form of book aspires to contribute to the evolution of drug delivery science, benefiting both pharmaceutical research and the broader healthcare landscape.
MICROENCAPSULATION IN PHARMACEUTICAL SCIENCE: UNVEILING THE LIMITATIONS, METHODS, AND APPLICATIONS OF MICROSPHERES, MICROCAPSULES, AND MICROPARTICLES
Authors: Thakur Priya , Kumari Pooja , Sonawane Shital Mahendra , Rao Avinash Kumar Rao
Published: September 2024

Microencapsulation, a crucial technique in the field of pharmaceutical science, involves enclosing active pharmaceutical ingredients (APIs) within microspheres, microcapsules, or microparticles. This study systematically explores the various facets of microencapsulation, encompassing its definition, advantages, disadvantages, methodologies, and diverse applications in the pharmaceutical sector. The definition section delves into the fundamental concept microencapsulation, elucidating of the process that protects APIs within a protective matrix. The research uncovers advantages such as improved drug stability, extended release, enhanced bioavailability, and minimized side effects. Concurrently, it critically examines potential drawbacks, including formulation challenges and scalability issues, providing a comprehensive perspective to optimize pharmaceutical applications. Methodologically, the study thoroughly reviews different microencapsulation techniques like spray drying, coacervation, and solvent evaporation. An evaluative analysis of their merits and limitations is presented, providing insights crucial for tailoring microencapsulation processes to specific drug characteristics and therapeutic requirements. The extensive realm of microencapsulation applications in pharmaceuticals is explored, ranging from controlled drug delivery and targeted therapy to taste masking and protecting sensitive compounds. The research meticulously scrutinizes these diverse applications, highlighting transformative potential the of microencapsulation in drug development and delivery. Through an in-depth analysis of microspheres, microcapsules, and microparticles, this research contributes valuable insights into their unique properties and applications in pharmaceutical formulations. The ultimate goal of this book chapter is to investigate the advance drug delivery systems, paving the way for more effective and patient friendly pharmaceutical products. This comprehensive resource aims to benefit researchers, pharmaceutical scientists, and industry professionals, enhancing their understanding of microencapsulation's pivotal role in shaping the future of pharmaceutical science.
TRANSDERMAL DRUG DELIVERY SYSTEMS: UNVEILING THE SCIENCE OF SKIN PERMEATION, INFLUENCING FACTORS, AND FORMULATION STRATEGIES
Authors: Vijayalakshmi, T. M. , Gaikwad Abhijit Anil , Beniwal Meenu , S Jailani.
Published: September 2024

This book chapter explores the complex world of gastroretentive drug delivery systems (GRDDS), providing an in-depth analysis of various approaches, pros, cons, and uses in the controlled drug delivery field. The importance of attaining gastroretention for prolonged drug release within the gastrointestinal tract is highlighted by the study's comprehensive examination of the various methodologies applied in the design of GRDDS. Through a thorough examination of the pros and cons of GRDDS, this study sheds light on the intricacies and compromises of using these systems for regulated medication delivery. This research shows that GRDDS has the ability to improve treatment results by delivering drugs more precisely and over longer periods of time. A more nuanced awareness of these systems' limitations and improvement prospects can be fostered by addressing the issues that come with them. The study also elucidates new approaches and potential uses for regulated medication delivery that are just starting to emerge. Offering a comprehensive and current review of GRDDS, this exploration is designed to cater to the demands of researchers, practitioners, and pharmaceutical experts. This research is significant for guiding future developments and breakthroughs in controlled drug delivery systems since it presents a balanced perspective on the tactics, benefits, drawbacks, and applications of GRDDS.