bluuebunny/crossref_metadata_2025 huggingface dataset:
DESIGUALDAD REGIONAL EN CASTILLA EN EL SIGLO XVIII
Authors: López Pérez María Del Mar , Tejada Ponce Ángel , Sánchez González María Pilar
Published: March 2022

Este trabajo presenta un análisis de la desigualdad regional en Castilla en la segunda mitad del siglo XVIII, a partir del estudio del consumo per cápita provincial calculado con las recaudaciones de dos rentas que supusieron los mayores ingresos fiscales del estado: alcabalas y cientos. La desigualdad regional presentó unos niveles reducidos y constantes durante la segunda mitad del siglo, analizando la productividad del trabajo, no encontrando elementos que alterasen significativamente la diferencia entre regiones. Asimismo, podemos señalar que se advierten las dificultades relacionadas con el sector agrario, con limitaciones a la producción y bajos rendimientos. Esas dificultades trataron de minimizarse con actuaciones reformistas que, no obstante, no tuvieron un claro impacto sobre la desigualdad, que permaneció homogénea.
The development of forms and functions of aggression during early childhood: A temperament-based approach
Authors: Ostrov Jamie M. , Murray-Close Dianna , Perry Kristin J. , Blakely-McClure Sarah J. , Perhamus Gretchen R. , Mutignani Lauren M. , Kesselring Samantha , Memba Gabriela V. , Probst Sarah
Published: March 2022

This study used a short-term longitudinal design with theoretically derived preregistered hypotheses and analyses to examine the role of temperament in the development of forms (i.e., physical and relational) and functions (i.e., proactive and reactive) of aggressive behavior in early childhood (N= 300, M age = 44.70 months,SD= 4.38, 44% girls). Temperament was measured via behavioral reports of emotional dysregulation, fearlessness/daring, and rule internalization/empathy and, in a subsample that completed a physiological assessment, via skin conductance and respiratory sinus arrhythmia. Emotion dysregulation generally served as a risk factor for all subtypes of aggression, with evidence of stronger associations with reactive as compared to proactive functions of relational aggression for girls. Daring predicted increases in physical aggression, especially among boys, and rule internalization predicted decreases in relational aggression, especially among girls. Rule internalization mediated longitudinal associations between daring and proactive relational aggression for girls. Some evidence also emerged supporting associations between adaptive functioning (i.e., high empathy, high respiratory sinus arrhythmia) and proactive functions of aggression. Findings highlight distinct temperamental risk factors for physical versus relational aggression and provide partial support for gender-linked theories of the development of aggression.
Liberal Democracy Needs Religion: Kant on the Ethical Community
Authors: Vanden Auweele Dennis
Published: March 2022

Liberal democracy has been experiencing a crisis of representation over the last decade, as a disconnect has emerged from some of the foundational principles of liberalism such as personal freedom and equality. In this article, I argue that in the third part of Kant’s Religion within the Boundaries of Mere Reason we can find resources to better understand and counteract this crisis of liberal democracy. Kant gives a powerful argument to include an invisible ethical community under a political community, and this ethical community has to take the form of a church. Kant argues then that any political system, and so also liberal democracy, requires religion to ally citizens in a foundational way with the general principles of that system. This would commit liberal nations to having their foundational principles buoyed by religion. Towards the close of the essay, I attend to how this might impact on liberalism’s commitment to religious and ideological pluralism.
Developing weight navigation program to support personalized and effective obesity management in primary care settings: protocol for a quality improvement program with an embedded single-arm pilot study
Authors: Griauzde Dina H. , Othman Amal , Dallas Chris , Oshman Lauren , Gabison Jonathan , Markel Dorene S. , Richardson Caroline R. , Kullgren Jeffrey T. , Piatt Gretchen , Heisler Michele , Kilbourne Amy M. , Kraftson Andrew
Published: March 2022

Background:

Primary care providers (PCPs) are expected to help patients with obesity to lose weight through behavior change counseling and patient-centered use of available weight management resources. Yet, many PCPs face knowledge gaps and clinical time constraints that hinder their ability to successfully support patients’ weight loss. Fortunately, a small and growing number of physicians are now certified in obesity medicine through the American Board of Obesity Medicine (ABOM) and can provide personalized and effective obesity treatment to individual patients. Little is known, however, about how to extend the expertise of ABOM-certified physicians to support PCPs and their many patients with obesity.

Aim:

To develop and pilot test an innovative care model – the Weight Navigation Program (WNP) – to integrate ABOM-certified physicians into primary care settings and to enhance the delivery of personalized, effective obesity care.

Methods:

Quality improvement program with an embedded, 12-month, single-arm pilot study. Patients with obesity and ≥1 weight-related co-morbidity may be referred to the WNP by PCPs. All patients seen within the WNP during the first 12 months of clinical operations will be compared to a matched cohort of patients from another primary care site. We will recruit a subset of WNP patients (n = 30) to participate in a remote weight monitoring pilot program, which will include surveys at 0, 6, and 12 months, qualitative interviews at 0 and 6 months, and use of an electronic health record (EHR)-based text messaging program for remote weight monitoring.

Discussion:

Obesity is a complex chronic condition that requires evidence-based, personalized, and longitudinal care. To deliver such care in general practice, the WNP leverages the expertise of ABOM-certified physicians, health system and community weight management resources, and EHR-based population health management tools. The WNP is an innovative model with the potential to be implemented, scaled, and sustained in diverse primary care settings.
Ancient China and the Responsibility to Protect: An Under-Studied Topic of Legal History
Authors: FENG Yuxi
Published: March 2022

While the Responsibility to Protect (“R2P”) doctrine synergizes modern international law against atrocities, its legal underpinnings formed in Europe much earlier. Scholarship thus attributes R2P's origin to the Just War traditions as early as the fourth century, which particularly endorsed external interventions against tyranny. The Ancient Chinese had championed similar ideas of Just War, encompassingjus ad bellumrecognition of war against unworthy sovereigns andjus in bello. Nevertheless, the Chinese traditions charted a different course. While in Europe, Just War rationalized the interventionist protection of co-religionists during the Reformation and later of oppressed Christians ruled by the Ottomans; the Chinese humanitarian expedition was discontinued by the advent of the Qin Empire. As R2P literature largely ignores ancient Chinese doctrines and practice, this paper investigates how they veered away from the pre-Qin traditions. It particularly illustrates how “tyranny” was perceived differently, and why “atrocity” and “minority protection” appeared alien concepts.
When Do Sources Persuade? The Effect of Source Credibility on Opinion Change
Authors: Clemm von Hohenberg Bernhard , Guess Andrew M.
Published: March 2022

Discussions around declining trust in the US media can be vague about its effects. One classic answer comes from the persuasion literature, in which source credibility plays a key role. However, existing research almost universally takes credibility as a given. To overcome the potentially severe confounding that can result from this, we create a hypothetical news outlet and manipulate to what extent it is portrayed as credible. We then randomly assign subjects to read op-eds attributed to the source. Our credibility treatments are strong, increasing trust in our mock source until up to 10 days later. We find some evidence that the resulting higher perceived credibility boosts the persuasiveness of arguments about more partisan topics (but not for a less politicized issue). Though our findings are mixed, we argue that this experimental approach can fruitfully enhance our understanding of the interplay between source trust and opinion change over sustained periods.
Impact of Climate Change on Hunter‐Fisher‐Gatherer Cultures in Northern Japan Over the Past 4,400 Years
Authors: Yamamoto Masanobu , Seki Osamu
Published: March 2022

In Hokkaido, northern Japan, densely populated societies of hunter‐fisher‐gatherer cultures persisted over the Holocene until the 19th century. We used the cellulose δ18O values of Sphagnum and vascular plants in peat cores from Rishiri Island to understand paleoclimate changes in Hokkaido over the past 4,400 years and discuss the impacts of climate changes on the development of the cultures. The cellulose δ18O values showed multi‐centennial and millennial variations, reflecting the intensity of the Tsushima Warm Current and the summer position of the westerly jet. The marine hunter‐fisher cultures responded to changes in the strength of Tsushima Warm Current and coastal primary production. In contrast, the inland cultures responded to changes in the latitudinal position of the summer westerlies. This implies that human societies of different lifestyles responded differently to climate changes.
Increased Variability of Biomass Burning Emissions in CMIP6 Amplifies Hydrologic Cycle in the CESM2 Large Ensemble
Authors: Heyblom Kyle B. , Singh Hansi A. , Rasch Philip J. , DeRepentigny Patricia
Published: March 2022

Historical simulations performed for the Coupled Model Intercomparison Project Phase 6 used biomass burning emissions between 1997 and 2014 containing higher spatial and temporal variability compared to emission inventories specified for earlier years, and compared to emissions used in previous (e.g., CMIP5) simulation intercomparisons. Using the Community Earth System Model version 2 Large Ensemble, we show this increased biomass burning emissions variability leads to amplification of the hydrologic cycle poleward of 40°N. Notably, the high variability of biomass burning emissions leads to increased latent heat fluxes, column‐integrated precipitable water, and precipitation. Greater ocean heat uptake, weaker meridional energy transport from the tropics, greater atmospheric shortwave and longwave absorption, and lower relative humidity act to moderate this hydrologic cycle amplification. Our results suggest it is not only the secular changes (on multidecadal timescales) in biomass burning emissions that impact the hydrologic cycle, but also the shorter timescale variability in emissions.
Representation of the Mean Atlantic Subtropical Cells in CMIP6 Models
Authors: Fu Yao , Brandt Peter , Tuchen Franz Philip , Lübbecke Joke F. , Wang Chunzai
Published: March 2022

The Atlantic Subtropical Cells (STCs) consist of poleward Ekman transport in the surface layer, subduction in the subtropics, and equatorward transport in the thermocline layer that largely compensates the surface Ekman divergence and closes the STCs via equatorial upwelling. As a result, the STCs play an important role in connecting the tropical and subtropical Atlantic Ocean, in terms of heat, freshwater, oxygen, and nutrients exchange. However, their representation in state‐of‐the‐art coupled models has not been systematically evaluated. In this study, we investigate the performance of the Coupled Model Intercomparison Project Phase 6 climate models in simulating the Atlantic STCs. Comparing model results with observations, we first present the simulated mean state with respect to ensembles of the key components participating in the STC loop, that is, the meridional Ekman and geostrophic flow across 10°N and 10°S, and the Equatorial Undercurrent (EUC) at 23°W. We find that the model ensemble reveals biases toward weak Southern Hemisphere Ekman transport and interior geostrophic transports, as well as a weak EUC. We then investigate the large inter‐model spread of these key components and find that models with strong Ekman divergence between 10°N and 10°S tend to have strong mixed layer and thermocline interior convergence and strong EUC. The inter‐model spread of the EUC strength is primarily associated with the intensity of the southeasterly trade winds in the models. Since the trade‐wind‐induced poleward Ekman transports are regarded as the drivers of the STCs, our results highlight the necessity to improve skills of coupled models to simulate the Southern Hemisphere atmospheric forcing.
H2O2 and CH3OOH (MHP) in the Remote Atmosphere: 1. Global Distribution and Regional Influences
Authors: Allen Hannah M. , Crounse John D. , Kim Michelle J. , Teng Alexander P. , Ray Eric A. , McKain Kathryn , Sweeney Colm , Wennberg Paul O.
Published: March 2022

Atmospheric hydroperoxides are a significant component of the atmosphere's oxidizing capacity. Two of the most abundant hydroperoxides, hydrogen peroxide (H2O2) and methyl hydroperoxide (MHP, CH3OOH), were measured in the remote atmosphere using chemical ionization mass spectrometry aboard the NASA DC‐8 aircraft during the Atmospheric Tomography Mission. These measurements present a seasonal investigation into the global distribution of these two hydroperoxides, with near pole‐to‐pole coverage across the Pacific and Atlantic Ocean basins and from the marine boundary layer to the upper troposphere and lower stratosphere. H2O2 mixing ratios are highest between 2 and 4 km altitude in the equatorial region of the Atlantic Ocean basin, where they reach global maximums of 3.6–6.5 ppbv depending on season. MHP mixing ratios reach global maximums of 4.3–8.6 ppbv and are highest between 1 and 3 km altitude, but peak in different regions depending on season. A major factor contributing to the global H2O2 distribution is the influence of biomass burning emissions in the Atlantic Ocean basin, encountered in all four seasons, where the highest H2O2 mixing ratios were found to correlate strongly with increased mixing ratios of the biomass burning tracers hydrogen cyanide (HCN) and carbon monoxide (CO). This biomass burning enhanced H2O2 by a factor of 1.3–2.2, on average, in the Atlantic compared with the Pacific Ocean basin.
How Fluvial Deposits Distort Aquifer Recharge Estimated From Groundwater Age: Insights From a Landscape Evolution Model
Authors: Rongier Guillaume , Peeters Luk
Published: March 2022

Sustainable management of groundwater relies on robust estimates of aquifer fluxes. As such, recharge can be estimated from groundwater age using analytical models assuming a homogeneous aquifer. We propose to assess how this assumption affects recharge estimates in fluvial deposits. First, we use CHILD, a landscape evolution model, to generate plausible deposits after tens of thousands of years of river evolution. Then, we use the fractional packing model to compute porosity and permeability of unconsolidated sediments assuming a mixture of a coarse and a fine fraction. Finally, we use PFLOTRAN to simulate groundwater flow and mean age over two thousand years of spatially uniform recharge. This reproduces the boundary conditions underlying Vogel's analytical model to estimate recharge rates. Our results are based on 20,000 realizations from varying inputs: grain sizes, aggradation rate of the river, porosity, recharge, etc. For most models, the mean estimate of the recharge rate remains below an absolute error of 25%. But fluvial heterogeneities can lead to local errors ranging from close to zero to several thousand percent, which means that estimates may vary drastically depending on sampling locations. A sensitivity analysis using the δ‐importance measure and CUSUNORO curves exposes how fluvial processes influence the range and distribution of the error. For instance, a high bank erodibility and small coarse grain size under low aggradation rates favor the reworking of deposits, which increases heterogeneity and leads to high errors. This work paves the way for a more reliable estimation of recharge by considering the sedimentary context.
Metamaterial-enhanced near-field readout platform for passive microsensor tags
Authors: Wu Ke , Duan Guangwu , Zhao Xiaoguang , Chen Chunxu , Anderson Stephan William , Zhang Xin
Published: March 2022

Radiofrequency identification (RFID), particularly passive RFID, is extensively employed in industrial applications to track and trace products, assets, and material flows. The ongoing trend toward increasingly miniaturized RFID sensor tags is likely to continue as technology advances, although miniaturization presents a challenge with regard to the communication coverage area. Recently, efforts in applying metamaterials in RFID technology to increase power transfer efficiency through their unique capacity for electromagnetic wave manipulation have been reported. In particular, metamaterials are being increasingly applied in far-field RFID system applications. Here, we report the development of a magnetic metamaterial and local field enhancement package enabling a marked boost in near-field magnetic strength, ultimately yielding a dramatic increase in the power transfer efficiency between reader and tag antennas. The application of the proposed magnetic metamaterial and local field enhancement package to near-field RFID technology, by offering high power transfer efficiency and a larger communication coverage area, yields new opportunities in the rapidly emerging Internet of Things (IoT) era.
Diversity and origins of bacterial and archaeal viruses on sinking particles reaching the abyssal ocean
Authors: Luo Elaine , Leu Andy O , Eppley John M , Karl David M , DeLong Edward F
Published: March 2022

Sinking particles and particle-associated microbes influence global biogeochemistry through particulate matter export from the surface to the deep ocean. Despite ongoing studies of particle-associated microbes, viruses in these habitats remain largely unexplored. Whether, where, and which viruses might contribute to particle production and export remain open to investigation. In this study, we analyzed 857 virus population genomes associated with sinking particles collected over three years in sediment traps moored at 4000 m in the North Pacific Subtropical Gyre. Particle-associated viruses here were linked to cellular hosts through matches to bacterial and archaeal metagenome-assembled genome (MAG)-encoded prophages or CRISPR spacers, identifying novel viruses infecting presumptive deep-sea bacteria such as Colwellia, Moritella, and Shewanella. We also identified lytic viruses whose abundances correlated with particulate carbon flux and/or were exported from the photic to abyssal ocean, including cyanophages. Our data are consistent with some of the predicted outcomes of the viral shuttle hypothesis, and further suggest that viral lysis of both autotrophic and heterotrophic prokaryotes may play a role in carbon export. Our analyses revealed the diversity and origins of prevalent viruses found on deep-sea sinking particles and identified prospective viral groups for future investigation into processes that govern particle export in the open ocean.
Sialylation of TLR2 initiates osteoclast fusion
Authors: Dou Ce , Zhen Gehua , Dan Yang , Wan Mei , Limjunyawong Nathachit , Cao Xu
Published: March 2022

The molecular control of osteoclast formation is still not clearly elucidated. Here, we show that a process of cell recognition mediated by Siglec15-TLR2 binding is indispensable and occurs prior to cell fusion in RANKL-mediated osteoclastogenesis. Siglec15 has been shown to regulate osteoclastic bone resorption. However, the receptor for Siglec15 has not been identified, and the signaling mechanism involving Siglec15 in osteoclast function remains unclear. We found that Siglec15 bound sialylated TLR2 as its receptor and that the binding of sialylated TLR2 to Siglec15 in macrophages committed to the osteoclast-lineage initiated cell fusion for osteoclast formation, in which sialic acid was transferred by the sialyltransferase ST3Gal1. Interestingly, the expression of Siglec15 in macrophages was activated by M-CSF, whereas ST3Gal1 expression was induced by RANKL. Both Siglec15-specific deletion in macrophages and intrafemoral injection of sialidase abrogated cell recognition and reduced subsequent cell fusion for the formation of osteoclasts, resulting in increased bone formation in mice. Thus, our results reveal that cell recognition mediated by the binding of sialylated TLR2 to Siglec15 initiates cell fusion for osteoclast formation.
Extracellular ATP promotes breast cancer chemoresistance via HIF-1α signaling
Authors: Yang Hui , Geng Yue-Hang , Wang Peng , Zhang Hong-Quan , Fang Wei-Gang , Tian Xin-Xia
Published: March 2022

We have previously demonstrated that extracellular adenosine 5'-triphosphate (ATP) promotes breast cancer cell chemoresistance. However, the underlying mechanism remains unclear. Using a cDNA microarray, we demonstrated that extracellular ATP can stimulate hypoxia-inducible factor (HIF) signaling. In this study, we report that hypoxia-inducible factor 1α (HIF-1α) was upregulated after ATP treatment and mediated the ATP-driven chemoresistance process. We aimed to investigate the mechanisms and identify potential clinically relevant targets that are involved. Using mass spectrometry, we found that aldolase A (ALDOA) interacts with HIF-1α and increases HIF-1α expression. We then demonstrated that STAT3-ALDOA mediates ATP-HIF-1α signaling and upregulates the HIF-1 target genes adrenomedullin (ADM) and phosphoinositide-dependent kinase-1 (PDK1). Moreover, we show that PI3K/AKT acts upstream of HIF-1α in ATP signaling and contributes to chemoresistance in breast cancer cells. In addition, HIF-1α-knockdown or treatment with direct HIF inhibitors combined with the ATP hydrolase apyrase in MDA-MB-231 cells induced enhanced drug sensitivity in nude BALB/c mice. We then used in vitro spheroid formation assays to demonstrate the significance of ATP-HIF-1α in mediating chemoresistance. Furthermore, considering that indirect HIF inhibitors are effective in clinical cancer therapy, we treated tumor-bearing BALB/c mice with STAT3 and PI3K/AKT inhibitors and found that the dual-targeting strategy sensitized breast cancer to cisplatin. Finally, using breast cancer tissue microarrays, we found that ATP-HIF-1α signaling is associated with cancer progression, poor prognosis, and resistance to chemotherapy. Taken together, we suggest that HIF-1α signaling is vital in ATP-driven chemoresistance and may serve as a potential target for breast cancer therapies.
Metformin suppresses the growth of colorectal cancer by targeting INHBA to inhibit TGF-β/PI3K/AKT signaling transduction
Authors: Xiao Qing , Xiao Jiani , Liu Jiaqi , Liu Jiaxin , Shu Guang , Yin Gang
Published: March 2022

Multiple evidence shows that metformin serves as a potential agent for Colorectal Cancer (CRC) treatment, while its molecular mechanisms still require detailed investigation. Here, we revealed that metformin specifically suppressed the proliferation of CRC cells by causing G1/S arrest, and INHBA is a potential target for metformin to play an anti-proliferation effect in CRC. We verified the oncogene role of INHBA by knocking down and overexpressing INHBA in CRC cells. Silencing INHBA abrogated the cell growth, while overexpression INHBA promotes the proliferation of CRC cells. As an oncogene, INHBA was aberrant overexpression in CRC tissues and closely related to the poor prognosis of CRC patients. In mechanism, INHBA is an important ligand of TGF-β signaling and metformin blocked the activation of TGF-β signaling by targeting INHBA, and then down-regulated the activity of PI3K/Akt pathway, leading to the reduction of cyclinD1 and cell cycle arrest. Together, these findings indicate that metformin down-regulates the expression of INHBA, then attenuating TGF-β/PI3K/Akt signaling transduction, thus inhibiting the proliferation of CRC. Our study elucidated a novel molecular mechanism for the anti-proliferation effect of metformin, providing a theoretical basis for the application of metformin in CRC therapy.
Downregulation of MUC15 by miR-183-5p.1 promotes liver tumor-initiating cells properties and tumorigenesis via regulating c-MET/PI3K/AKT/SOX2 axis
Authors: Han Tao , Zheng Hao , Zhang Jin , Yang Pinghua , Li Hengyu , Cheng Zhangjun , Xiang Daimin , Wang Ruoyu
Published: March 2022

Mucin 15 (MUC15) is reportedly aberrant in human malignancies, including hepatocellular carcinoma (HCC). However, the role of MUC15 in the regulation of liver tumor-initiating cells (T-ICs) remains unknown. Here, we report that expression of MUC15 is downregulated in liver T-ICs, chemoresistance and recurrent HCC samples. Functional studies reveal that MUC15 inhibits hepatoma cells self-renewal, malignant proliferation, tumorigenicity, and chemoresistance. Mechanistically, MUC15 interacts with c-MET and subsequently inactivates the PI3K/AKT/SOX2 signaling pathway. Moreover, we find that miR-183-5p.1 directly targets MUC15 3′-UTR in liver T-ICs. Coincidentally, SOX2 feedback inhibits MUC15 expression by directly transactivating miR-183-5p.1, thus completing a feedforward regulatory circuit in liver T-ICs. Importantly, MUC15/c-MET/PI3K/AKT/SOX2 axis determines the responses of hepatoma cells to lenvatinib treatment, and MUC15 overexpression abrogated lenvatinib resistance. Analysis of patient cohort, patient-derived tumor organoids and patient-derived xenografts further suggests that the MUC15 may predict lenvatinib benefits in HCC patients. Collectively, our findings suggest the crucial role of the miR-183-5p.1/MUC15/c-MET/PI3K/AKT/SOX2 regulatory circuit in regulating liver T-ICs properties, suggesting potential therapeutic targets for HCC.
Molecular basis of apoptotic DNA fragmentation by DFF40
Authors: Ha Hyun Ji , Park Hyun Ho
Published: March 2022

Although the functions of CIDE domain-containing proteins, including DFF40, DFF45, CIDE-A, CIDE-B, and FSP27, in apoptotic DNA fragmentation and lipid homeostasis have been studied extensively in mammals, the functions of four CIDE domain-containing proteins identified in the fly, namely DREP1, 2, 3, and 4, have not been explored much. Recent structural study of DREP4, a fly orthologue of mammalian DFF40 (an endonuclease involved in apoptotic DNA fragmentation), showed that the CIDE domain of DREP4 (and DFF40) forms filament-like assembly, which is critical for the corresponding function. The current study aimed to investigate the mechanism of filament formation of DREP4 CIDE and to characterize the same. DREP4 CIDE was shown to specifically bind to histones H1 and H2, an event important for the nuclease activity of DREP4. Based on the current experimental results, we proposed the mechanism underlying the process of apoptotic DNA fragmentation.
In-degree centrality in a social network is linked to coordinated neural activity
Authors: Baek Elisa C. , Hyon Ryan , López Karina , Finn Emily S. , Porter Mason A. , Parkinson Carolyn
Published: March 2022

Convergent processing of the world may be a factor that contributes to social connectedness. We use neuroimaging and network analysis to investigate the association between the social-network position (as measured by in-degree centrality) of first-year university students and their neural similarity while watching naturalistic audio-visual stimuli (specifically, videos). There were 119 students in the social-network study; 63 of them participated in the neuroimaging study. We show that more central individuals had similar neural responses to their peers and to each other in brain regions that are associated with high-level interpretations and social cognition (e.g., in the default mode network), whereas less-central individuals exhibited more variable responses. Self-reported enjoyment of and interest in stimuli followed a similar pattern, but accounting for these data did not change our main results. These findings show that neural processing of external stimuli is similar in highly-central individuals but is idiosyncratic in less-central individuals.
The role of lattice dynamics in ferroelectric switching
Authors: Shi Qiwu , Parsonnet Eric , Cheng Xiaoxing , Fedorova Natalya , Peng Ren-Ci , Fernandez Abel , Qualls Alexander , Huang Xiaoxi , Chang Xue , Zhang Hongrui , Pesquera David , Das Sujit , Nikonov Dmitri , Young Ian , Chen Long-Qing , Martin Lane W. , Huang Yen-Lin , Íñiguez Jorge , Ramesh Ramamoorthy
Published: March 2022

Reducing the switching energy of ferroelectric thin films remains an important goal in the pursuit of ultralow-power ferroelectric memory and logic devices. Here, we elucidate the fundamental role of lattice dynamics in ferroelectric switching by studying both freestanding bismuth ferrite (BiFeO3) membranes and films clamped to a substrate. We observe a distinct evolution of the ferroelectric domain pattern, from striped, 71° ferroelastic domains (spacing of ~100 nm) in clamped BiFeO3films, to large (10’s of micrometers) 180° domains in freestanding films. By removing the constraints imposed by mechanical clamping from the substrate, we can realize a ~40% reduction of the switching voltage and a consequent ~60% improvement in the switching speed. Our findings highlight the importance of a dynamic clamping process occurring during switching, which impacts strain, ferroelectric, and ferrodistortive order parameters and plays a critical role in setting the energetics and dynamics of ferroelectric switching.
Antimicrobial resistance and population genomics of multidrug-resistant Escherichia coli in pig farms in mainland China
Authors: Peng Zhong , Hu Zizhe , Li Zugang , Zhang Xiaoxue , Jia Chaoying , Li Tianzhi , Dai Menghong , Tan Chen , Xu Zhuofei , Wu Bin , Chen Huanchun , Wang Xiangru
Published: March 2022

The expanding use of antimicrobials in livestock is an important contributor to the worldwide rapid increase in antimicrobial resistance (AMR). However, large-scale studies on AMR in livestock remain scarce. Here, we report findings from surveillance of E. coli AMR in pig farms in China in 2018–2019. We isolated E. coli in 1,871 samples from pigs and their breeding environments, and found AMR in E. coli in all provinces in mainland China. We detected multidrug-resistance in 91% isolates and found resistance to last-resort drugs including colistin, carbapenems and tigecycline. We also identified a heterogeneous group of O-serogroups and sequence types among the multidrug-resistant isolates. These isolates harbored multiple resistance genes, virulence factor-encoding genes, and putative plasmids. Our data will help to understand the current AMR profiles of pigs and provide a reference for AMR control policy formulation for livestock in China.
Pushing detectability and sensitivity for subtle force to new limits with shrinkable nanochannel structured aerogel
Authors: Shi Xinlei , Fan Xiangqian , Zhu Yinbo , Liu Yang , Wu Peiqi , Jiang Renhui , Wu Bao , Wu Heng-An , Zheng He , Wang Jianbo , Ji Xinyi , Chen Yongsheng , Liang Jiajie
Published: March 2022

There is an urgent need for developing electromechanical sensor with both ultralow detection limits and ultrahigh sensitivity to promote the progress of intelligent technology. Here we propose a strategy for fabricating a soft polysiloxane crosslinked MXene aerogel with multilevel nanochannels inside its cellular walls for ultrasensitive pressure detection. The easily shrinkable nanochannels and optimized material synergism endow the piezoresistive aerogel with an ultralow Young’s modulus (140 Pa), numerous variable conductive pathways, and mechanical robustness. This aerogel can detect extremely subtle pressure signals of 0.0063 Pa, deliver a high pressure sensitivity over 1900 kPa−1, and exhibit extraordinarily sensing robustness. These sensing properties make the MXene aerogel feasible for monitoring ultra-weak force signals arising from a human’s deep-lying internal jugular venous pulses in a non-invasive manner, detecting the dynamic impacts associated with the landing and take-off of a mosquito, and performing static pressure mapping of a hair.
ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheimer’s disease models
Authors: Zhao Yuanyuan , Hu Di , Wang Rihua , Sun Xiaoyan , Ropelewski Philip , Hubler Zita , Lundberg Kathleen , Wang Quanqiu , Adams Drew J. , Xu Rong , Qi Xin
Published: March 2022

Predisposition to Alzheimer’s disease (AD) may arise from lipid metabolism perturbation, however, the underlying mechanism remains elusive. Here, we identify ATPase family AAA-domain containing protein 3A (ATAD3A), a mitochondrial AAA-ATPase, as a molecular switch that links cholesterol metabolism impairment to AD phenotypes. In neuronal models of AD, the 5XFAD mouse model and post-mortem AD brains, ATAD3A is oligomerized and accumulated at the mitochondria-associated ER membranes (MAMs), where it induces cholesterol accumulation by inhibiting gene expression of CYP46A1, an enzyme governing brain cholesterol clearance. ATAD3A and CYP46A1 cooperate to promote APP processing and synaptic loss. Suppressing ATAD3A oligomerization by heterozygous ATAD3A knockout or pharmacological inhibition with DA1 restores neuronal CYP46A1 levels, normalizes brain cholesterol turnover and MAM integrity, suppresses APP processing and synaptic loss, and consequently reduces AD neuropathology and cognitive deficits in AD transgenic mice. These findings reveal a role for ATAD3A oligomerization in AD pathogenesis and suggest ATAD3A as a potential therapeutic target for AD.
Improving the oxygen redox reversibility of Li-rich battery cathode materials via Coulombic repulsive interactions strategy
Authors: Li Qingyuan , Ning De , Wong Deniz , An Ke , Tang Yuxin , Zhou Dong , Schuck Götz , Chen Zhenhua , Zhang Nian , Liu Xiangfeng
Published: March 2022

The oxygen redox reaction in lithium-rich layered oxide battery cathode materials generates extra capacity at high cell voltages (i.e., >4.5 V). However, the irreversible oxygen release causes transition metal (TM) dissolution, migration and cell voltage decay. To circumvent these issues, we introduce a strategy for tuning the Coulombic interactions in a model Li-rich positive electrode active material, i.e., Li1.2Mn0.6Ni0.2O2. In particular, we tune the Coulombic repulsive interactions to obtain an adaptable crystal structure that enables the reversible distortion of TMO6 octahedron and mitigates TM dissolution and migration. Moreover, this strategy hinders the irreversible release of oxygen and other parasitic reactions (e.g., electrolyte decomposition) commonly occurring at high voltages. When tested in non-aqueous coin cell configuration, the modified Li-rich cathode material, combined with a Li metal anode, enables a stable cell discharge capacity of about 240 mAh g−1 for 120 cycles at 50 mA g−1 and a slower voltage decay compared to the unmodified Li1.2Mn0.6Ni0.2O2.
Acute kidney rejection after anti-SARS-CoV-2 virus-vectored vaccine—case report
Authors: Vnučák Matej , Graňák Karol , Beliančinová Monika , Jeseňák Miloš , Macháleková Katarína Kajová , Benko Jakub , Samoš Matej , Dedinská Ivana
Published: March 2022

COVID-19 infection remains a threat to the health systems of many countries. Potential success in the fight against the COVID-19 pandemic is the vaccination of high-risk groups, including patients with end-stage kidney disease (ESKD) and after solid organ transplantation (SOT). Immunosuppression in kidney transplant recipients can also reduce the immunogenicity of SARS-CoV-2 vaccines (varied by vaccine platform), available data suggest that they are efficacious in approximately 50–70%, compared to non-transplant situations. In this paper, we present a newly developed acute humoral and cellular rejection with acute allograft failure and need of hemodialysis 14 days after administration of the adenovirus vectored SARS-CoV-2 vaccine (AstraZeneca; CHADOx1, AZD1222). This occurred in a patient who previously had an asymptomatic COVID-19 infection. Case reports of acute allograft rejection after vaccination against SARS-CoV-2 can help stratify risk groups of patients who develop hyperimmune reactions. However, it is also possible that those with a previous mild primary COVID-19 infection may also develop acute allograft rejections upon COVID-19 re-infection.
Data on the diets of Salish Sea harbour seals from DNA metabarcoding
Authors: Thomas Austen C. , Deagle Bruce , Nordstrom Chad , Majewski Sheena , Nelson Benjamin W. , Acevedo-Gutiérrez Alejandro , Jeffries Steven , Moore Jed , Louden Amelia , Allegue Hassen , Pearson Scott , Schmidt Michael , Trites Andrew W.
Published: March 2022

Marine trophic ecology data are in high demand as natural resource agencies increasingly adopt ecosystem-based management strategies that account for complex species interactions. Harbour seal (Phoca vitulina) diet data are of particular interest because the species is an abundant predator in the northeast Pacific Ocean and Salish Sea ecosystem that consumes Pacific salmon (Oncorhynchus spp.). A multi-agency effort was therefore undertaken to produce harbour seal diet data on an ecosystem scale using, 1) a standardized set of scat collection and analysis methods, and 2) a newly developed DNA metabarcoding diet analysis technique designed to identify prey species and quantify their relative proportions in seal diets. The DNA-based dataset described herein contains records from 4,625 harbour seal scats representing 52 haulout sites, 7 years, 12 calendar months, and a total of 11,641 prey identifications. Prey morphological hard parts analyses were conducted alongside, resulting in corresponding hard parts data for 92% of the scat DNA samples. A custom-built prey DNA sequence database containing 201 species (192 fishes, 9 cephalopods) is also provided.
Dataset of ultralow temperature refrigeration for COVID 19 vaccine distribution solution
Authors: Sun Jian , Zhang Mingkan , Gehl Anthony , Fricke Brian , Nawaz Kashif , Gluesenkamp Kyle , Shen Bo , Munk Jeff , Hagerman Joe , Lapsa Melissa , Awwad Nader , Recipe Chris , Auyer Doug , Brisson David
Published: March 2022

Most COVID-19 vaccines require temperature control for transportation and storage. Two types of vaccine have been developed by manufacturers (Pfizer and Moderna). Both vaccines are based on mRNA and lipid nanoparticles requiring low temperature storage. The Pfizer vaccine requires ultra-low temperature storage (−80 °C to −60 °C), while the Moderna vaccine requires −30 °C storage. However, the last stage of distribution is quite challenging, especially for rural or suburban areas, where local towns, pharmacy chains and hospitals may not have the infrastructure required to store the vaccine at the required temperature. In addition, there is limited data available to address ancillary challenges of the distribution framework for both transportation and storage stages, including safety concerns due to human exposure to large amounts of CO2 from dry-ice sublimation, issues due to the pressure increase caused by dry-ice sublimation, and the potential issue caused by non-uniform cryogenic temperatures. As such, there is a need for test dataset to assist the development of a quick, effective, secure, and safe solution to mitigate the challenges faced by vaccine distribution logistics.
Validation and refinement of cropland data layer using a spatial-temporal decision tree algorithm
Authors: Lin Li , Di Liping , Zhang Chen , Guo Liying , Di Yahui , Li Hui , Yang Anna
Published: March 2022

Space-based crop identification and acreage estimation have played a significant role in agricultural studies in recent years, due to the development of Remote Sensing technology. The Cropland Data Layer (CDL), which was developed by the U.S. Department of Agriculture (USDA), has been widely used in agricultural studies and achieved massive success in recent years. Although the CDL’s accuracy assessments report high overall accuracy on various crops classifications, misclassification is still common and easy to discern from visual inspection. This study is aimed to identify and resolve inaccurate crop classification in CDL. A decision tree method was employed to find questionable pixels and refine them with spatial and temporal crop information. The refined data was then evaluated with high-resolution satellite images and official acreage estimates from USDA. Two validation experiments were also developed to examine the data at both the pixel and county level. Data generated from this research was published online in two repositories, while both applications allow users to download the entire dataset at no cost.
Investigating adult age differences in real-life empathy, prosociality, and well-being using experience sampling
Authors: Pollerhoff Lena , Stietz Julia , Depow Gregory John , Inzlicht Michael , Kanske Philipp , Li Shu-Chen , Reiter Andrea M. F.
Published: March 2022

While the importance of social affect and cognition is indisputable throughout the adult lifespan, findings of how empathy and prosociality develop and interact across adulthood are mixed and real-life data are scarce. Research using ecological momentary assessment recently demonstrated that adults commonly experience empathy in daily life. Furthermore, experiencing empathy was linked to higher prosocial behavior and subjective well-being. However, to date, it is not clear whether there are adult age differences in daily empathy and daily prosociality and whether age moderates the relationship between empathy and prosociality across adulthood. Here we analyzed experience-sampling data collected from participants across the adult lifespan to study age effects on empathy, prosocial behavior, and well-being under real-life circumstances. Linear and quadratic age effects were found for the experience of empathy, with increased empathy across the three younger age groups (18 to 45 years) and a slight decrease in the oldest group (55 years and older). Neither prosocial behavior nor well-being showed significant age-related differences. We discuss these findings with respect to (partially discrepant) results derived from lab-based and traditional survey studies. We conclude that studies linking in-lab experiments with real-life experience-sampling may be a promising venue for future lifespan studies.
Influence of heat flow control on dynamical spin injection in CoFeB/Pt/CoFeB trilayer
Authors: Obinata Sora , Iimori Riku , Ohnishi Kohei , Kimura Takashi
Published: March 2022

A dynamical spin injection based on the ferromagnetic resonance in a ferromagnetic/nonmagnetic bi-layered structure, is a powerful mean for generating and manipulating the spin current. Although the mechanism of the dynamical spin injection is mainly attributed to the spin pumping, the detailed mechanism and the quantitative understanding for related phenomena are still controversial. As an another important contribution to the dynamical spin injection, the heating effect due to the resonant precessional motion of the magnetization is pointed out recently. In order to quantify the contribution from the heating effect, we here investigate the dynamical spin injection in a CoFeB/Pt/CoFeB trilayer. Although the contribution from the spin pumping diminishes because of the symmetric spin injection from the upper and lower interfaces, a significant inverse spin Hall voltage has been clearly observed. We show that the observed voltage can be quantitatively understood by the thermal spin injection due to a heating effect during the ferromagnetic resonance. A proper combination between the spin pumping and the heat-flow control in the multi-layered system is a key for the efficient dynamical spin injection.
From Khoi-San indigenous knowledge to bioengineered CeO2 nanocrystals to exceptional UV-blocking green nanocosmetics
Authors: Ditlopo N. , Sintwa N. , Khamlich S. , Manikandan E. , Gnanasekaran K. , Henini M. , Gibaud A. , Krief A. , Maaza M.
Published: March 2022

Single phase CeO2 nanocrystals were bio-synthesized using Hoodia gordonii natural extract as an effective chelating agent. The nanocrystals with an average diameter of 〈Ø〉 ~ 5–26 nm with 4+ electronic valence of Ce displayed a remarkable UV selectivity and an exceptional photostability. The diffuse reflectivity profile of such CeO2 exhibited a unique UV selectivity, in a form of a Heaviside function-like type profile in the solar spectrum. While the UV reflectivity is significantly low; within the range of 0.7%, it reaches 63% in the VIS and NIR. Their relative Reactive Oxygen Species (ROS) production was found to be < 1 within a wide range of concentration (0.5–1000 μg/ml). This exceptional photostability conjugated to a sound UV selectivity opens a potential horizon to a novel family of green nano-cosmetics by green nano-processing.
Genetically related genotypes of cowpea present similar bacterial community in the rhizosphere
Authors: de Albuquerque Tayná Mendes , Mendes Lucas William , Rocha Sandra Mara Barbosa , Antunes Jadson Emanuel Lopes , Oliveira Louise Melo de Souza , Melo Vania Maria Maciel , Oliveira Francisca Andrea Silva , Pereira Arthur Prudêncio de Araujo , da Silva Veronica Brito , Gomes Regina Lucia Ferreira , de Alcantara Neto Francisco , Lopes Angela Celis de Almeida , de Moura Rocha Maurisrael , Araujo Ademir Sergio Ferreira
Published: March 2022

Plant breeding reduces the genetic diversity of plants and could influence the composition, structure, and diversity of the rhizosphere microbiome, selecting more homogeneous and specialized microbes. In this study, we used 16S rRNA sequencing to assess the bacterial community in the rhizosphere of different lines and modern cowpea cultivars, to investigate the effect of cowpea breeding on bacterial community assembly. Thus, two African lines (IT85F-2687 and IT82D-60) and two Brazilian cultivars (BRS-Guariba and BRS-Tumucumaque) of cowpea were assessed to verify if the generation advance and genetic breeding influence the bacterial community in the rhizosphere. No significant differences were found in the structure, richness, and diversity of bacterial community structure between the rhizosphere of the different cowpea genotypes, and only slight differences were found at the OTU level. The complexity of the co-occurrence network decreased from African lines to Brazilian cultivars. Regarding functional prediction, the core functions were significantly altered according to the genotypes. In general, African lines presented a more abundance of groups related to chemoheterotrophy, while the rhizosphere of the modern cultivars decreased functions related to cellulolysis. This study showed that the genetic breeding process affects the dynamics of the rhizosphere community, decreasing the complexity of interaction in one cultivar. As these cowpea genotypes are genetically related, it could suggest a new hypothesis of how genetic breeding of similar genotypes could influence the rhizosphere microbiome.