bluuebunny/crossref_metadata_2025 huggingface dataset:
ENGANANDO O CITOCROMO P450BM3: CATÁLISE DE VÁRIAS TRANSFORMAÇÕES DE SUBSTRATOS NÃO NATIVOS USANDO MOLÉCULAS-TRAIÇOEIRAS
Authors: Stanfield Joshua , Suzuki Kazuto , Yonemura Kai , Malewschik Talita , Shoji Osami
Published: April 2021

TRICKING CYTOCHROME P450BM3: CATALYSIS OF VARIOUS NON-NATIVE SUBSTRATE TRANSFORMATIONS USING DECOY MOLECULES. In order to accomplish a greener chemistry, enzymes, such as the fatty-acid hydroxylase cytochrome P450BM3, have garnered increasing attention as potential candidates for the development of potent biocatalysts in recent years. However, one of the biggest issues hampering the quick and efficient application of P450BM3 as a biocatalyst lies in its stringent substrate specificity. Consequently, diverse mutagenesis-based approaches have been successfully employed as a means to alter the substrate specificity of P450BM3, leading to the generation of a myriad of highly specialised mutant variants. Nevertheless, repeated exhaustive mutagenesis is a laborious process with no guarantee for success, thus, alternative methods to more easily alter the enzyme’s substrate specificity have become increasingly desirable. In recent years, decoy molecules, which possess the ability to deceive wild-type P450BM3 into hydroxylating a range of non-native substrates, have emerged as such a “simpler” alternative. Within this review, focus will be placed upon the process underlying the development of these decoy molecules, which will be discussed in great detail. Furthermore, a summary of recent developments pertaining to the potential applications of decoy molecules from the development of a whole-cell biocatalyst to their use in crystallography will be discussed.
Religious and Tolerant Attitudes of University Students: A Comparative Study
Authors: Rifa'i Andi Arif
Published: April 2021

This research focuses on plurality of two Indonesian state university students, namely IAIN Syaikh Abdurrahman Siddik Bangka Belitung and Bangka Belitung University. This research aimed at finding out an idea of how the attitude of these PTN students in Bangka Belitung in dealing with the plurality. This quantitative research found that IAIN students are more exclusive as far as the belief system is concerned. Whereas in the context of inclusiveness, IAIN students are more inclusive in the belief that every religion contains truth and UBB students hold the same opinion. Regarding the attitude of students, UBB students are more pluralist in terms of rejecting missionaries, while the students of the IAIN are more pluralist in terms of the purpose of the truth of each religious teaching. Moreover, UBB students are more universalist in their view that religions are different because of historical factors. While in the moderate category of 2.76%, there are no intolerant students. Based on the results of various tests (t-test), it is shown that there are significant differences between IAIN and UBB students.
Fostering Religious Tolerance in West Papua: A Case Study of Muhammadiyah's Higher-educational Institutions
Authors: Akib Muhaiminah , Hartanti Rezkiah , Suaib Hermanto
Published: April 2021

This study aims to identify the role of Muhammadiyah's higher-educational institutions in fostering religious tolerance in West Papua. Applying the qualitative method, this research is conducted in three Muham­­­ma­diyah higher-educational institutions in West Papua i.e., Universitas Muham­madiyah Sorong (UM Sorong) Sorong City, Uni­versitas Pendidikan Muham­madiyah Sorong (UNIMUDA) Sorong Regency, and Sekolah Tinggi Keguruan dan Ilmu Pen­didikan (STKIP) Muham­ma­diyah Manok­wari. The results showed that Muham­ma­diyah’s higher-educational institutions are inclusive in terms of spiritual understanding. In fostering religious tolerance there are three approaches taken by the three Muhammadiyah higher-educational institutions in West Papua: 1) social approach, 2) cultural approach, and 3) excellent service approaches. The strategies implemented the role includes: 1) dissem­ina­ting Muham­madiyah’s vision and mission, 2) inculcating tolerance values since the beginning of students joining Muham­madiyah higher-educational institutions, 3) strengthening tolerance value by lecturing processes, conducting, sharing sessions both formally and informally, and 4) empowering student activity units and other facilities that support multicultural student interaction processes.
The Construction of Chinese Muslim Identities in Surabaya
Authors: Yunariono Bastian , Andriati Retno
Published: April 2021

This study aims to uncover how Chinese Muslims in Surabaya developed their identity in Post-Reformation. During the New Order regime, they could not show their identity as a part of Indonesian diversity. Chinese identity has merged with the “native” people. Along with the downfall of the authoritarian political system and the development of multiculturalism and pluralism, Chinese Muslims in Surabaya could express their cultural identity. This study uses a qualitative method with an ethnographic approach. The results of the study reveal that the Chinese Muslims in Surabaya developed their cultural identity through Cheng Hoo Mosque, Chinese Muslim Organization, and Imlek Celebration. The cultural identity created a hybrid identity which is a combination of Chinese, Java, and Islamic cultures.
Dam failure peak outflow prediction through GEP-SVM meta models and uncertainty analysis
Authors: Nobarinia Mohammad , Kalateh Farhoud , Nourani Vahid , Amini Alireza Babaeian
Published: April 2021

Accurate prediction of a breached dam's peak outflow is a significant factor for flood risk analysis. In this study, the capability of Support Vector Machine and Kernel Extreme Learning Machine as kernel-based approaches and Gene Expression Programming method was assessed in breached dam peak outflow prediction. Two types of modeling were considered. First, only dam reservoir height and volume at the failure time were used as the input combinations (state 1). Then, soil characteristics were added to input combinations to investigate particularly the impact of soil characteristics (state 2). Results showed that the use of only soil characteristics did not lead to a desired accuracy; however, adding soil characteristics to input combinations (state 2) improved the models' accuracy up to 40%. The outcome of the applied models was also compared with existing empirical equations and it was found the applied models yielded better results. Sensitivity analysis results showed that dam height had the most important role in the peak outflow prediction, while the strength parameters did not have significant impacts. Furthermore, for assessing the best-applied model dependability, uncertainty analysis was used and the results indicated that the SVM model had an allowable degree of uncertainty in peak outflow modelling.
Biodegradation of alicyclic amines by a newly isolated hypersaline tolerant strain Paenarthrobacter sp. TYUT067
Authors: Feng Kaiqing , Zhang Jiandong , Gao Lili , Tian Qi
Published: April 2021

Alicyclic amines are widely used in several types of industries, and considerable attention has been devoted to possible environmental pollution by alicyclic amines in hypersaline industrial wastewater. In this study, a new hypersaline tolerant bacterial TYUT067 capable of growing in liquid basal salt medium with cyclohexylamine (CHAM) as the sole carbon source and energy source, was isolated from soil, and discovered with highly efficient CHAM degrading ability. The strain TYUT067 was identified as Paenarthrobacter sp. based on 16S rDNA gene sequence, and its degradation characteristic was examined. The results revealed that the isolated TYUT067 could grow well under pH range of 6.5–10.0, temperature from 20 °C to 30 °C. For degradation of 60 mM of cyclohexylamine, 100% degradation could be finished within 120 h. The TYUT067 could degrade 10 mM CHAM under hypersaline conditions (3–5% NaCl, w/v), revealed the hypersaline tolerance of TYUT067. Different type of amines was also tested with TYUT067, the degradations of >90% were achieved toward several alicyclic amines. The current results suggested that TYUT067 was a potential species could be efficiently used for the degradation of alicyclic amines and might be applicable to a hypersaline wastewater treatment system for the removal of alicyclic amines.
Current status of textile wastewater management practices and effluent characteristics in Tanzania
Authors: Bidu J. M. , Van der Bruggen B. , Rwiza M. J. , Njau K. N.
Published: April 2021

Textile wastewater from wet processing units is a major environmental problem. Most chemicals, including dyes, are only partly consumed, resulting in highly colored wastewater containing a variety of chemicals released into the environment. This paper gives information on the current management of textile wastewater in Tanzania. A semiquantitative analysis was done to identify the main types of chemicals used in wet processing units, wastewater characteristics and existing wastewater treatment methods in the textile industry. The performance evaluation of the existing wastewater treatment plants is also discussed. The advantages of integrating constructed wetlands with the existing treatment facilities for textile wastewater are explained. It has been observed that pretreatment and dying/printing of the fabrics are the main two processes that produce wastewater in many textile companies. Main pollutants are chemicals used from pretreatment and materials removed from de-sizing, bleaching and scouring processes. Dyes, printing pigments and dye auxiliaries are the main pollutants from the dyeing/printing process. Most of the textile companies in Tanzania are equipped with effluent treatment plants. Wastewater treatment plants have basically similar units, which are coagulation-flocculation, sedimentation through clarifiers and aerobic reactor. However, their effluents do not meet discharge limits stipulated by the Tanzania Bureau of Standards (TBS).
ESCOLAS DE LUTA
Authors: Souza Ana Karla Pontes de
Published: April 2021

Resenha da obra: 

CAMPOS, Antonia J. M.; MEDEIROS, Jonas; RIBEIRO, Márcio M. Escolas de luta. São Paulo: Veneta, 2016. 352 p.; ISBN 978-85-63137-69-2.
Training nursing staff who have been victim of work labour harassment on the island of Crete in strengthen of their self-esteem with anonymous group psychotherapy through teleconferencing
Authors: Maniou Maria , Christos Kleisiaris , Zyga Sofia , Vliamos Spyros , Prezerakos Panagiotis , Flora Katerina , Togas Konstantinos
Published: April 2021

Background: Professional self-esteem for nursing profession refers to the extent to which a person experiences its work as important while appreciating its performance as important. There is evidence that self-esteem is important for health. The majority of the victims of occupational harassment of nursing staff have a middle self – esteem. Purpose: This study tests the effectiveness of adding a fourteen weeks schema-focused Anonymous group psychotherapy via teleconference in victims of workplace harassment in nursing personnel in the island of Crete, Greece. Method: An investigation was carried out in the area of Crete between August 2017 and January 2018 in fourteen Health Centers, two Primary National Health Networks, four Emergency Department, eleven Intensive Care Units. The total sample of the present study was 213 nurses. This case–control study was carried out by α qualified psychologist. The participants were 14 nurses victims of workplace harassment assigned randomly to psychotherapy group and a control group to enhance of their self-esteem. Results: Statistically significant difference are presented in the psychotherapy group during a 14-week period for the scale of General Selfesteem (p-value = 0.002) measured with the Culture Free Self-Esteem Inventories. Conclusions: Anonymous group psychotherapy via teleconference is a safe and effective method for treating self - esteem in victims of workplace harassment. KEYWORDS: Anonymous group psychotherapy, Teleconference, Self-esteem, Nursing Personnel
Luiz Carlos da Silva, o Luiz Si: produção artística e atuação socioeducativa em Joinville
Authors: Larizza Bergui de Andrade  , Nadja de Carvalho Lamas
Published: April 2021

O presente artigo expõe a atuação artística, social e educativa do artista plástico Luiz Carlos da Silva (1941-2011) na cidade de Joinville. Apresenta a contribuição relevante de seu trabalho como pintor e como professor de desenho e pintura da Escola de Artes Fritz Alt, instalada na Casa da Cultura Fausto Rocha Júnior, que auxiliou na formação de novos artistas de Joinville e região, e sua atuação socioeducativa pelo Projeto O Artista na Educação, delineado e executado pelo próprio artista em 21 escolas municipais de Joinville. Questiona-se, no entanto, o fato de o artista ainda não ter sido citado em pesquisas científicas na cidade, tendo em vista a sua relevante contribuição educativa, social e artística. A pesquisa, de caráter qualitativo, fez uso da análise documental de fontes primárias (catálogos e convites de exposições e matérias de jornais) e de pesquisa de campo com entrevistas e observação de campo. A pesquisa resultou em um registro sobre o artista, suas produções artísticas e sua atuação socioeducativa em Joinville, que colaborou para a sistematização da história da arte em Joinville e em Santa Catarina.
Proposta teórico-metodológica de inventário cultural participativo no Vale do Paraíba e Litoral Norte, São Paulo
Authors: Cilene Gomes  , Valéria Regina Zanetti  , André Bazanella
Published: April 2021

O artigo retrata a experiência da rede colaborativa denominada Observatório da Paisagem do Vale do Paraíba, São Paulo, centrada na agregação de agentes e ações com interesse comum em questões relativas à preservação do patrimônio cultural e das paisagens culturais no contexto amplo da discussão atual sobre o desenvolvimento regional-metropolitano. Com o objetivo de ensaiar um caminho teórico-metodológico que estimule a ampliação de investigações e o debate social, utilizaram-se como metodologia de elaboração do artigo o relato de experiências e a análise documental e bibliográfica. Chega-se a uma proposição teórico-metodológica fundada nas orientações conceituais do espírito dos lugares e da paisagem cultural e no desafio metodológico, debatido e consensuado no observatório, de realização de inventários culturais participativos.
Editorial
Authors: Kasprowicz Adriane
Published: April 2021

Editorial
Reserva Biológica Estadual Mata Paludosa: paisagem, memória e patrimônio natural
Authors: Aline Beatriz Pacheco Carvalho  , Judite Sanson de Bem  , Cristina Vargas Cademartori
Published: April 2021

O texto problematiza os conceitos de patrimônio natural e de paisagem como expressão da memória e da identidade da comunidade de Itati, município do litoral norte do estado do Rio Grande do Sul. No contexto da Reserva Biológica Estadual Mata Paludosa, enfatizam-se as consequências do desaparecimento de elementos da natureza, por conta das ações antrópicas que impedem o retorno das paisagens naturais às condições originais. Abordam-se os conceitos de paisagem e memória e sua inter-relação, como resultado das distintas formas pelas quais as comunidades ou grupos interagem com o ambiente. Ainda, analisam-se aspectos da criação da Reserva Biológica Estadual Mata Paludosa, considerando seus objetivos e dificuldades no que concerne à conservação da biodiversidade, e o desafio posto pela disseminação da espécie invasora uva-do-japão, que compromete a conservação do patrimônio natural no Rio Grande do Sul.
O ofício do profissional de História no tempo presente: entrevista com Durval Muniz de Albuquerque Júnior
Authors: Ilanil Coelho
Published: April 2021

Antes de mais nada, agradeço o aceite do convite para você conhecer a nossa universidade, vir a Joinville pela primeira vez e abrir a XXV Semana de História da Univille3. Estamos felizes com a sua presença e aproveitamos para conversar um pouco sobre alguns temas que nos são muito caros e sobre os quais você tem experiência e reflexão: patrimônio, o ofício do historiador e os desafios do ensino de História na atualidade. Começo justamente pelo primeiro tema: na sua opinião, quais os desafios hoje abertos quando a gente considera os usos e abusos da ideia de patrimônio cultural? E, se puder, faça também um balanço com base em sua própria experiência.
Os vales do museu contam a história: a emissão de dinheiro de emergência na Colônia Dona Francisca do século XIX
Authors: Nicolas Marcos  , Sandra Paschoal Leite de Camargo Guedes
Published: April 2021

O Museu Nacional de Imigração e Colonização de Joinville (MNIC), criado no ano de 1957, está localizado no centro da cidade em um edifício construído em 1870 e tombado pelo Instituto do Patrimônio Histórico e Artístico Nacional em 1939. É um dos museus mais visitados de Santa Catarina e conta com um acervo de mais de sete mil peças, entre elas um conjunto de vales produzidos na própria cidade no fim do século XIX. Essa coleção é desconhecida pelo público e ainda não foi pesquisada. Assim, o objetivo deste trabalho é entender a função social do acervo de numismática do MNIC, por meio de sua relação com a história de criação do museu. A metodologia de trabalho, que está em desenvolvimento, consiste na revisão de literatura acerca da história do MNIC, bem como na investigação dos processos de musealização exercidos para a formação da coleção de vales. Trabalho interdisciplinar, essa discussão enquadra-se numa problemática maior que insere a importância do estudo dos acervos dos museus que compõem o patrimônio cultural brasileiro. A análise inicial aponta para uma ligação estreita da coleção de numismática com o propósito inicial do MNIC, que foi de preservar a memória do período colonizador de Joinville e das pessoas diretamente envolvidas em tal fase. Essa constatação está fundamentada em algumas características do acervo de vales, principalmente as assinaturas de personagens conhecidas e destacadas pela história oficial da cidade. Dessa forma, o museu e seu acervo de numismática refletem uma memória pautada pela história das personalidades importantes de Joinville, cuja função simbólica busca desenvolver uma representação sobre a história do município e uma visão própria da identidade joinvilense.
Literatura digitalizada: preservação e divulgação da memória literária maranhense
Authors: Emanoel Cesar Pires de Assis  , Ana Paula Nunes de Sousa  , Alanna Costa da Silva
Published: April 2021

Considerando a importância e a necessidade de preservação e divulgação da memória literária maranhense, este trabalho tem por objetivo destacar as possibilidades de pesquisa em acervos digitalizados, como as práticas de preservação realizadas no acervo literário da Academia Caxiense de Letras, instituição não governamental que sobrevive de doações. Esta é uma pesquisa de cunho qualitativo e quantitativo que consiste em um processo seletivo, organizacional e de sistematização de dados, disponibilizados no sítio da internet O Portal Maranhão, e cujo aporte teórico se funda nas ideias de Boeres e Arellano (2005), Braga e Diemer (2010), Bordini (2006, 2009), Greenhalgh (2011), Nardino (2004), Reifschneider (2008), Santos (2013) e Sousa, Correia e Assis (2018), que defendem a catalogação eletrônica de acervos como um instrumento de preservação e abertura de novos horizontes de pesquisas literárias.
Tempo, patrimônio e alimento: análise de alguns modelos culturais no Slow Food
Authors: Henrique Budal Arins  , Patrícia de Oliveira Areas
Published: April 2021

Este artigo objetiva problematizar as utilizações de tempo no patrimônio e na alimentação por meio da análise de alguns modelos culturais em estudo de caso do movimento Slow Food. Para tal, estruturaram-se suas partes conceituais antes da análise do estudo de caso. A primeira parte pretende discutir como a construção do tempo é utilizada para as definições de patrimônio e como impacta as relações identitárias, memoriais ou no apagamento do patrimônio alimentar. A segunda problematiza a caracterização de tempo na lógica de mercado em contraponto à lógica substantiva, contestando o mercado como centro das relações humanas, ao reprimir o valor cultural pelo valor monetário. A pesquisa utiliza como procedimento metodológico a análise bibliográfica, para construção das categorias de análise do estudo de caso, realizado por intermédio de pesquisa documental do objeto em estudo: o movimento Slow Food. A pesquisa percebe uma alteração nos modelos culturais mais substantivos nas ações do Slow Food.
Impact factors on oral health related quality of life in patients requiring orthognathic surgery
Authors: Juliana Reuter Pereira  , Grasielle Vicentini  , Michelle Nascimento Meger  , Nelson Luis Barbosa Rebellato  , Rafaela Scariot  , Aline Monise Sebastiani
Published: April 2021

Individuals with dentofacial deformities have a greater negative impact on oral health and in quality of life. The aim of this study was identified the main factors involved in the perception of the oral health related quality of life in individuals with dentofacial deformities. Material and methods: In a crosssectional study, were evaluated 72 individuals in preoperative period of orthognathic surgery at the Oral and Maxillofacial Surgery Service at Federal University of Paraná and at Positivo University. The age, gender, facial profile, presence or absence of asymmetry and temporomandibular disorders (TMD) symptoms were accessed. Through the Oral Health Impact Profile-14 (OHIP-14) the perceptions about oral health related quality of life of the patients was accessed. The TMD symptoms were evaluated with Fonseca anamnestic index. Data were submitted to descriptive and inferential statistical analysis with a significance level of 0.05. Results: The OHIP-14 mean score was higher with increasing age (p= 0.007), in females (p= 0.076), asymmetric patients (p= 0.030). and according to the increase in reported TMD symptoms (p= 0.001). Individuals with no TMD symptoms had an OHIP-14 mean of 8.86±8.06; individuals with mild TMD had a mean of 15±6.28, moderate TMD had a mean of 20.6 ± 9.44 and severe TMD had a mean of 26.42±7.66. There were no differences between OHIP-14 and type of facial profile (p= 0.725). Conclusion: It is concluded that increasing age, female gender, presence of asymmetry and the severity of TMD symptoms are important factors related to poor oral health related quality of life in individuals with dentofacial deformities.
Resistência à fratura por fadiga cíclica de instrumentos endodônticos reciprocantes de níquel titânio tratados termicamente
Authors: Bruno Carvalho de Sousa  , Lana Alice Carvalho Araújo  , Everton Araújo Maciel  , Marcos Bruno Araujo  , Luiz Carlos Trevia Morais Correia Viana  , Humberto Ramah Menezes de Matos
Published: April 2021

A evolução na fabricação de instrumentos endodônticos permitiu o desenvolvimento de limas de níquel-titânio tratadas termicamente com características e propriedades superiores às suas antecessoras. No entanto as fraturas ainda acontecem, por torção ou por fadiga cíclica. A fratura por torção ocorre quando a extremidade permanece imóvel e o restante rotaciona em seu longo eixo. A fratura por fadiga cíclica acontece em virtude de desgaste com a utilização do instrumento, em que sofre tensão e compressão em sua superfície repetidas vezes. Objetivo: Avaliar a resistência à fratura por fadiga cíclica de 36 limas endodônticas de níquel titânio com tratamento térmico (12 Reciproc Blue R25 e 24 Prodesign R25/.06) submetidas ao teste em dispositivos que simulam o canal radicular, com raio de 6 mm e ângulos de curvatura de 45º e 60º. Material e métodos: Os instrumentos foram divididos em 6 grupos, com 6 limas em cada. Grupo 1: Reciproc Blue R25 em 45º; grupo 2: Reciproc BlueR25 em 60º; grupo 3: Prodesign R25/.06 (cinemática Reciproc All) em 45º; grupo 4: Prodesign R25/.06 (cinemática Reciproc All) em 60º; grupo 5: Prodesign R25/.06 (cinemática Wave One) em 45º; grupo 6: Prodesign R25/.06 (cinemática Wave One) em 60º. Os instrumentos foram condicionados no dispositivo e acionados a motor, e o tempo foi mensurado até a ocorrência da fratura. Os resultados foram analisados estatisticamente por meio dos testes Anova e Turkey HSD, com intervalo de confiança de 95%. Resultados: Observou-se que houve diferença estatisticamente significante entre os grupos (p>0,05). As limas Prodesign R25/.06 acionadas na cinemática Reciproc All (45º e 60º) e na cinemática Wave One (45º) mostraramse superiores às Reciproc Blue em relação à resistência à fratura por fadiga cíclica. Conclusão: Houve diferença na resistência à fratura entre os instrumentos avaliados, em que os instrumentos Prodesign R25/.06 apresentaram os melhores resultados.
Reconstrução de avulsão parcial de pavilhão auricular por etiologia traumática: relato de caso
Authors: Kalyne Kelly Negromonte Gonçalves  , Demóstenes Alves Diniz  , Thawan Lucas Rodrigues Mendonça  , Mariane Ferreira Rodrigues de Melo  , Caio César Gonçalves Silva  , Marcelo Soares dos Santos  , Belmiro Cavalcanti do Egito Vasconcelos
Published: April 2021

Os acidentes motociclísticos são um dos principais responsáveis pelas internações hospitalares, superlotando as emergências. As lesões envolvendo o complexo bucomaxilofacial frequentemente encontradas nesses pacientes estão relacionadas aos traumas envolvendo os tecidos moles. Objetivo: Relatar um caso clínico de um paciente vítima de acidente motociclístico, evoluindo com avulsão parcial do pavilhão auricular direito. Relato de caso: Paciente do sexo masculino, 58 anos de idade, compareceu ao serviço de Cirurgia e Traumatologia Bucomaxilofacial do Hospital da Restauração, em Recife (PE), vítima de acidente motociclístico. Ele relatou não usar equipamento de proteção individual no momento do acidente. Ao exame físico apresentava avulsão parcial do pavilhão auricular direito e queixa de déficit auditivo após trauma. O exame de imagem não sugeria fratura em ossos da face. O paciente foi submetido ao protocolo de vacina antitetânica e antibioticoterapia. Seguiu-se com limpeza da ferida, desbridamento e reconstrução do pavilhão auricular mediante suturas. Após alta, o paciente foi encaminhado às equipes de cirurgia plástica e otorrinolaringologista. Conclusão: É importante refletir acerca do manejo de ferimentos de tecidos moles envolvendo o complexo maxilofacial, em virtude do potencial risco de sequelas permanentes que tais lesões podem proporcionar aos pacientes acometidos.
Aplicação de toxina botulínica tipo A em paciente com paralisia facial periférica de Bell: relato de caso
Authors: Camila Ferreira dos Santos  , Karen Cristiane de Almeida Stresser  , Ane Micheline Machado de Oliveira  , Cláudia Salete Judachesc  , Viviane Rozeira Crivellaro  , Gisele Correr  , Marcelo de Lima Oliveira  , João César Zielak
Published: April 2021

A toxina botulínica (TB) é uma neurotoxina que pode ser usada em diversos tratamentos na Odontologia, como, por exemplo, na aplicação em pacientes com paralisia periférica de Bell (PPB). Nesses casos, a musculatura facial do lado contralateral à paralisia pode evoluir com espasticidade, sendo necessário o relaxamento dos músculos envolvidos para a harmonização orofacial do paciente. Objetivo: Demonstrar a harmonização orofacial em paciente com PPB por meio da aplicação de TB tipo A. Relato de caso: Paciente, 55 anos, homem, apresentando paralisia hemifacial, recebeu aplicação de TB com finalidade de reequilíbrio do tônus muscular, a fim de reduzir a espasticidade dos músculos orbicular dos olhos, levantador do lábio superior e asa do nariz, risório e orbicular dos lábios, no lado oposto ao da paralisia. Conclusão: No paciente do atual relato de caso, o uso de toxina botulínica proporcionou um resultado de harmonização orofacial e, segundo o próprio paciente, houve influência positiva também na autoestima e convívio social.
İşbirlikli Öğrenme ile Zenginleştirilmiş ARCS Motivasyon Modelinin İngilizce Öğrenim Motivasyonuna Etkisi
Authors: Önce Elif Büşra , Gürol Mehmet
Published: April 2021

Bu araştırmada, üniversite hazırlık sınıfı öğrencilerinin İngilizce öğrenme motivasyonunu artırmak için İşbirlikli öğrenme ile zenginleştirilmiş Attention Relevance Confidence Satisfaction (ARCS) Motivasyon Modeli kullanılmıştır. Araştırma, ARCS motivasyon modelinin uygulandığı deney grubu (n=23) ve geleneksel öğretimin uygulandığı kontrol grubu (n=24) ile yürütülmüştür. Öğrenci motivasyonları, “Öğretim Materyalleri Motivasyon Anketi” ile araştırmacı tarafından hazırlanmış Öğrenme Günlükleri kullanılarak ölçülmüştür. Verilerin analizi için İlişkili Örneklemler t- Testi ve İlişkisiz Örneklemler t- Testi kullanılmıştır. Nitel verilerin analizi için ise içerik analizi kullanılmıştır. Araştırma sonucunda deney ve kontrol grubunun Öğretim Materyalleri Motivasyon Ölçeği alt boyutlarından aldıkları puan ortalamaları arasında toplam faktörlerde (dikkat, uygunluk, güven ve doyum) ve birinci faktörde (dikkat ve uygunluk) istatistiksel olarak anlamlı bir farklılık saptanmıştır. İçerik analizi sonucunda ise Öğrenme Motivasyonu Teması içerisinde Duygusal ve Sosyal Etki olmak üzere iki kategori bazında katılımcılar ARCS Motivasyon modelini etkili bulduklarını ifade etmişlerdir. Bu çalışmadan hareketle, işbirlikli öğrenme ile zenginleştirilmiş ARCS motivasyon modelinin İngilizce öğrenme motivasyonunu arttırdığı söylenebilir.
The Role of Chest High Resolution CT and RT-PCR in Diagnosis of Different Stages of Coronavirus (COVID-19) Pneumonia
Authors: Kassem Mohamed N.E. , Masallat Doaa T.
Published: April 2021

Purpose:

The purpose of this study is to investigate how RT-PCR (real time–polymerase-chain-reaction) and chest High-Resolution Computed Tomography
(HRCT) can detect COVID-19 (Coronavirus Disease 2019) disease in the early, progressive and severe stages, as well as patient’s outcome.

Method:

We perform a prospective study with chest HRCT on 206 patients with positive RT-PCR test. The patients were divided into three groups; early
stage (100 patients), progressive stage (70 patients) and severe stage (36 patients).

Results:

The early stage involved typical category (COVID-19 Reporting and Data System, CO-RADS 5, 34 cases - 34%), indeterminate category (CORADS
3, six cases - 6%), atypical category (CO-RADS 4, ten cases - 10%) and normal chest HRCT imaging (CO-RADS 1, 50 cases - 50%). The
progressive stage involved a typical category (CO-RADS 5, 70 cases, 100%), The severe stage involved a typical category (CO-RADS 5, 36 cases,
100%).

Conclusion:

RT-PCR is the gold standard and specific tool for confirming COVID-19 infection. Combination of RT-PCR and chest HRCT is used for the early
diagnosis of COVID-19 pneumonia. Chest HRCT is positive in 50% of patients in the early stage of COVID-19. Chest HRCT is not only detecting
pulmonary parenchymal changes but also determining patient’s outcome in the progressive and severe stages of COVID-19 (CO-RADS 5).
Patients with progressive stage will not need ventilator and patients with severe stage should receive ventilator.
Insight Into Bioactive Hydrogels for Wound Healing and Drug
Delivery Systems
Authors: Li Jing , Chen Qinhua , Wang Jin , Pan Xiaoyan , Zhang Jie
Published: April 2021

:

Hydrogels are hydrophilic but water-soluble polymer systems with a three-dimensional
network structure. They can absorb large amounts of water and maintain their
shape and remain soft. The high-moisturizing properties, good biocompatibility, and controlled
biodegradability of hydrogels have allowed them to be widely used in wound
dressing, tissue engineering, controlled drug delivery systems, and other fields. This article
reviews the most widely used antibacterial gel dressings for wound healing in recent
years and focuses on the application of an environmentally responsive intelligent hydrogel
delivery system. Finally, the development prospects and challenges of hydrogel
wound dressings are forecasted.
The Impact of Physical Exercise on the Hippocampus in Physiological Condition and Ageing-Related Decline: Current Evidence from Animal and Human Studies
Authors: Lauretta Giovanni , Ravalli Silvia , Maugeri Grazia , D’Agata Velia , Rosa Michelino Di , Musumeci Giuseppe
Published: April 2021

Physical exercise (PE), notoriously, promotes a state of general well-being, throughout the entire human lifespan. Moreover, maintaining an adequate and regular PE habit results in a powerful preventive factor towards many diseases and may also help in managing existing pathological conditions. PE induces structural and functional changes in various parts of the body, determining biological and psychological benefits. Additionally, in the elderly, PE might represent a remarkable tool reducing cognitive impairments related to the normal aging processes and it has also been found to have an impact on neurodegenerative diseases such as Alzheimer’s disease. The present review aims to provide an overview of PE effects on the hippocampus, since it is one of the brain regions most susceptible to aging and, therefore, involved in diseases characterized by cognitive impairment.
Mechanism of Natural Drugs on Nonalcoholic Fatty Liver Disease
Authors: Xie Jiao , Li Ling , Zhao Lei
Published: April 2021

:

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the
world. Its pathogenesis is closely related to insulin resistance
Anti-aging Natural Compounds and their Role in the Regulation of Metabolic Pathways Leading to Longevity
Authors: Muzammil Aqsa , Waqas Muhammad , Umar Ahitsham , Sufyan Muhammad , Rehman Abdur , Haider Ali , Akram Haseeb , Khan Seemab Amjad Fateh , Afzal Muhammad , Wajid Muhammad , Tahir Rana Adnan , Sehgal Sheikh Arslan
Published: April 2021

Aging is an unavoidable process, leading to cell senescence due to physiochemical changes
in an organism. Anti-aging remedies have always been of great interest since ancient times. The purpose
of anti-aging activities is to increase the life span and the quality of life. Anti-aging activities are
primarily involved in the therapies of age-related disorders such as Parkinson's Disease (PD), Alzheimer's
Disease (AD), cardiovascular diseases, cancer, and chronic obstructive pulmonary diseases. These
diseases are triggered by multiple factors that are involved in numerous molecular pathways including
telomere shortening, NF-κB pathway, adiponectin receptor pathway, insulin, and IGF signaling
pathway, AMPK, mTOR, and mitochondria dysfunction. Natural products are known as effective molecules
to delay the aging process through influencing metabolic pathways and thus ensure an extended
lifespan. These natural compounds are being utilized in drug design and development through computational
and high throughput techniques for effective pro-longevity drugs. A comprehensive study on
natural compounds demonstrating their anti-aging activities along with databases of natural products
for drug designing was executed and summarized in this review article.
Wound Healing Properties of Exosomes — A Review and Modelling
of Combinatorial Analysis Strategies
Authors: Liew Fong Fong , Chew Boon Cheng , Ooi Der Jiun
Published: April 2021

:

Wound healing is an elaborated process, well-regulated via cell migration and proliferation. Although the physiological basics of wound healing have been thoroughly investigated and reported, much remain to be studied. Particularly, various studies have demonstrated the immunomodulatory roles of exosomes derived from plant cells, mammalian cells and mesenchymal stem cells (MSCs) in the healing and repair system. The paracrine and therapeutic effects of exosomes are mainly associated with the broad exosomal cargo content comprising of growth factors, cytokines, enzymes, nucleic acids, proteins and lipid signaling molecules. Nevertheless, functional or mechanism pathway of exosomes with reference to overall exosomal cargo remains undetermined. To date, combinatorial analysis strategies employing Database for Annotation, Visualization, and Integrated Discovery (DAVID), STRING tools, Gene Ontology (GO), Kyoto Encyclopedia of Genes, Genomes (KEGG) pathway enrichment analysis, as well as Ingenuity Pathway Analysis (IPA) have been applied in elucidating network interaction and functional pathway of exosomes. In this review paper, application of combinatorial analysis strategies is demonstrated to better understand on the therapeutic potentials of exosomes in wound healing process. In conclusion, functional modulation of exosomal cargo for specify biological treatment is achievable, modelling of combinatorial analysis strategies will hopefully bridge the research gap and provides a paradigm shift to regenerative processes.
Management of Procedural Pain in Children
Authors: Páramo-Cano Tatjana , Ortiz Mario I. , Gómez-Busto Federico J. , Espinoza-Ramírez Ana L.
Published: April 2021

:

In recent years, there has been increased interest in the study of pain in children and its treatment. It is known that when facing diagnostic and therapeutic procedures similar to those performed on adults, children either do not receive specific pain treatment or receive it on a significantly lower scale. However, recent research suggests a change in attitude and an improvement in the current treatment of children's pain. Although current knowledge demonstrates the falsity of many preconceived ideas about pain and its management, our results suggest that attitudinal change towards childhood pain remains slow and that real improvement in the training and practical application of the pediatrician who has to treat childhood pain is urgently needed. In this context, this manuscript has prepared standards and guidelines to improve pain management practices in a large number of national and international professional settings.
A Study of Pregnancy-Related Anxiety with Spiritual Health Among Cesarean and Vaginal Delivery
Authors: Haydari Naval , Dejbakhat Majid , Akbarzadeh Marzieh
Published: April 2021

Background:

One of the most important causes of anxiety during pregnancy is postpartum anxiety and the effects that this anxiety can have on the health of mother and infant and the role that studies have considered for spiritual health in promoting mental health.

Objective:

the aim of this study is to investigate the correlation between anxiety and spiritual health of mothers with cesarean section and vaginal delivery.

Methods:

This study was performed on 171 women referred to Amir al-momenin (PB) in Gerash Hospital (Fars, Iran) from August 2017 to October 2018. Convenience sampling was used. Data were collected through Demographic Information Questionnaire, Spielberger Anxiety Inventory, and Pulotzin and Ellison Spiritual Health Questionnaire. Data were analyzed by descriptive statistical methods including mean, standard deviation and frequency percentage and analytical methods, such as independent t-test and Pearson correlation.

Results:

There was no significant difference between the mean of total score of anxiety (P = 0.560) and spiritual health (P = 0.313) in mothers with cesarean section and vaginal delivery). There was no significant correlation between maternal spiritual health, maternal anxiety, cesarean delivery (r = -0.111, p = 0.269) and vaginal delivery (r = 0.152, p = 0.209).

Conclusion:

In this study, anxiety and spiritual health were not different among cesarean section and vaginal delivery women and unlike other studies, no correlation was found between spiritual health and anxiety. However, further studies in this field and attention to other strategies to control labor anxiety among women seem necessary.
Dietary Nutrients and Prevention of Alzheimer’s Disease
Authors: Chauhan Pallavi Singh , Yadav Dhananjay , Arukha Ananta Prasad
Published: April 2021

:

Alzheimer’s disease is an irrevocable, progressive brain disorder that gradually destroys
memory and cognitive skills. One of the extensively studied methods of preventing Alzheimer’s
disease (AD) progression is by providing a nutritional diet. Several reports have shown that intake
of nutritional elements as huperzine A, ursolic acid, vitamins etc., can directly influence pathogenesis
of AD. Surprisingly, the occurrence of metabolic disorders due to an unhealthy diet has been
known to be a major environmental cause of AD. It has been noted that AD severity can be controlled
by supplementing dietary supplements containing huge amounts of health-promoting ingredients.
These elements promote cell health, regeneration, and the anti-aging process that specifically
interrupt the pathogenic pathways in AD development. Fortunately, incorporating changes in the
nutritional content is inexpensive, easy, acceptable, safe, effective, and in most cases, free from major
adverse events. Many nutritional phytoconstituents such as flavonoids, alkaloids, and terpenoids
are still being evaluated in the hope of identifying a successful therapy for AD. This review
discusses the therapeutical potential of several key nutrients that have been researched for
treating AD treatment and the method of their neuroprotective intervention.
The Role of Aldehyde Oxidase in the Metabolic Clearance of Substituted Benzothiazoles
Authors: Teffera Yohannes , Liu Jingzhou , Krolikowski Paul , Zhao Zhiyang
Published: April 2021

Introduction:

A group of substituted benzothiazoles from a research project was found
to have low microsomal clearance. However, these compounds had very high clearance in vivo.

Methods:

In the present study, the clearance mechanism of two of the structural analogs, was investigated
in vitro and in vivo.

Results:

In vitro studies showed the formation of corresponding non-P450 dependent oxidative
metabolites in S9, cytosol, and hepatocytes. The in vitro formation of these metabolites was observed
in mice, rats, non-human primates, and humans. The dog did not form the corresponding
metabolites in any of the matrices. Inhibition studies with S9 fraction and incubation with human
recombinant aldehyde oxidase (AO) showed that the formation of the corresponding metabolites
was AO dependent. To investigate the role of this pathway in vivo, mice were dosed with compound
A and bile and plasma were analyzed. Most of the metabolites in bile contained the AO-dependent
oxidized benzothiazole moiety, indicating that metabolism involving AO was probably the
main pathway for clearance. The same metabolites were also observed circulating in plasma. Mass
spectrometric analysis of the metabolite showed that the oxidation was on the benzothiazole moiety,
but the exact position could not be identified. Isolation of the metabolite of compound A and
analysis by NMR confirmed the structure of the metabolite as C2 carbon oxidation of the thiazole
ring resulting in carboxamide moiety. Further comparison of both metabolites with corresponding
authentic standards confirmed the structures.

Conclusion:

To our knowledge, such an observation of in vitro and in vivo oxidation of substituted
benzothiazole by AO has not been reported before. The results helped the medicinal chemists design
compounds that avoid AO-mediated metabolism and with better ADME property.
Profile of Amino Acid and Fatty Acid from Different Type of Worm as Feed of Broodstock Candidates for Domesticated Uceng (Nemacheilus fasciatus)
Authors: Anatus Sholikah Lik , Soeprijanto Agoes , Kilawati Yuni
Published: April 2021

Uceng fish (Nemacheilus fasciatus) is a fish that lives wild on the river. All this time, the people have only relied on fishing from nature to consume, but the high market demand for fish will increase river fishing activities in excess. One of the steps to suppress the decline in fish populations is domestication because currently, the fish is not yet cultivated. The domestication process by feeding worms containing amino acids and fatty acids accelerates broodstock candidates' gonadal development. This research aims to determine the type of worms suitable as feed for the growth and gonadal development of broodstock candidates. The method that used in this research is Completely Randomized Design (CRD) with 3 treatments and 3 repetitions. Based on the analysis of amino acids and fatty acids in each type of worm, the best results were obtained on Lumbricus rubellus with an amino acid content of 50.91 gr/100gr and fatty acid 292.27%.
Multiple inter-university online lesson programs in conflict areas-evaluation for improvement
Authors: Ikeda Mitsuru , Fukuda Aya
Published: April 2021

Peacebuilding and conflict prevention studies play a crucial role in promoting peace on earth. Such studies must be evaluated in order to ensure they are as effective as possible. At the Tokyo University of Foreign Studies (TUFS), Japan, Associate Professor Mitsuru Ikeda, Professor
Toru Miyagi and Dr Aya Fukuda are part of a team that have developed an educational programme on peacebuilding and conflict prevention that connects several universities in Asia via an online conference system. The Global Campus Program (GCP) is novel for many reasons, particularly because
of its psychological angle. Ikeda is a psychologist who is a proponent of the importance of the involvement of psychology in conflict prevention education. This is because armed conflicts are caused by the human mind and psychology is also closely linked to programme evaluation research. Through
the GCP, Ikeda, Miyagi and Fukuda are performing a programme evaluation of peacebuilding and conflict prevention education. This involves inviting students from different parts of the world, including conflict-affected countries and enhancing students' learning through interaction and dialogue.
The researchers use two major psychological theoretical models in their work: mere exposure effect and the idea that co-action based on common goals deepens mutual understanding.
An international comparative study of the influence of investment funds on enterprise management
Authors: Miwa Yumiko
Published: April 2021

In the world of business nowadays there is a focus on shareholders, and a lack of separation between ownership and management. Innovations in investment technology have led to a growth in the assets of institutional investors and an increased influence of investors. Indeed, many investors
have assumed the role of 'speaking shareholder' for the companies in question. This is referred to as hedge fund activism, with once silent investors becoming shareholders and, as a result, individuals and hedge funds are able to dominate the activities of companies. From the late 1990s to
the early 2000s this situation was centred around pension funds but now revolves around hedge funds. Professor Yumiko Miwa, Graduate School of Commerce, Meiji University, Japan, is conducting an international comparative study of the influence of investment funds on enterprise management.
This research investigates anti-takeover measures, preferential treatments and addresses potential conflicts of interest. In other research, Miwa is working to address the stance taken by some companies that women are socially disadvantaged. The topic of this research is Women Working in the
Capital Markets.
Educational practice of citizen science by ICT for the purpose of biodiversity conservation through domestic and international collaboration
Authors: Kobori Hiromi
Published: April 2021

Citizen Science is on the rise. It involves members of the public taking part in research and collecting datasets that can be used by academic institutions and can help foster innovations. Numerous Citizen Science projects are underway in the UK and US but the concept isn't as widespread
in Japan. In recent times, though, there have been efforts to engage the Japanese public in Citizen Science by demonstrating its benefits to society. Dr Hiromi Kobori, Tokyo City University, Japan, is exploring ways that Citizen Science innovations can boost the socialisation of science. This
involves enabling open science and encouraging citizens to proactively engage in the scientific process. The idea is to involve citizens in multiple research processes and foster a sense of co-creation between citizens and scientists. Kobori's Citizen Science project is contributing to overcoming
issues facing the natural and social environment and also involves the use of smartphones, which is an effective way to boost public involvement in science. Specifically, Kobori is involved in a project focusing on biodiversity and how its health can be restored and preserved. Her goal is
to re-establish the connection between living things and nature and form a sustainable society.