bluuebunny/crossref_metadata_2025 huggingface dataset:
Effectiveness of an interactive method in teaching investment literacy: Factors determining the return of beginning investors’ portfolios
Authors:   Novosibirsk State University, Bekareva Svetlana Viktorovna , Getmanova Anna Vladimirovna ,   Novosibirsk State University, Ivanova Anastasiya Igorevna ,   Novosibirsk State University
Published: October 2022

Introduction. The article examines how certain factors influence the efficiency of forming virtual portfolio of financial assets. The purpose of the article is to identify the factors that contribute to the investment return of beginning investors. Materials and Methods. The methodological basis of the study includes Russian and international research articles devoted to enhancing financial and investment literacy on the national level, the role of financial education in successful investments, and the factors of return estimations for various groups of investors, including young people and beginners. The research was carried out at Novosibirsk State University (the Faculty of Economics). Portfolios produced by 396 students majoring in Economics, Management, and IT Business, who completed the ‘Financial Markets and Financial Institutions’ module were analyzed. The portfolios were completed in 2020, 2021, and 2022. The dependent variable in the econometric model was an investment portfolio return. The main factors considered for this research included students' academic performance, academic year, degree programme, age, gender, and financial asset structure of each portfolio. Results. The review of the scholarly literature allowed to identify the following potential return factors: investment literacy, educational background, personal behaviour characteristics, gender, financial market shocks, and economic crises. It was found that portfolio return is determined by the following factors: economic instability influencing financial markets, students’ academic performance in finance disciplines which is closely connected to their investment literacy and personality features revealed in the portfolio structure. However, age, degree programme and gender did not show any significant influence on the project outcome. Conclusions. Identifying the factors of students’ investment portfolio return enabled the authors to determine further development of the financial course with the interactive method in teaching investing literacy. Taking into consideration economic instability factor significance, it is necessary to discuss financial assets characteristics and dynamics during economic crises. In general, investment literacy increase influences the result positively.
Cognitive-economic subjectivity of individual’s development in the formation of positive motivation for entrepreneurship: Evaluation of the effectiveness
Authors:   Toraighyrov University, Iskakova Anargul Batyrbayevna , Akhmetova Gulnas Kenzhetaevna ,   Al-Farabi Kazakh National University, Kairbayeva Akmaral Kanatbekovna ,   Toraighyrov University, Dossanov Talgat Sapargaliyevich ,   Toraighyrov University, Zeitova Sholpan Serikovna ,   Toraighyrov University, Nurumzhanova Kulyash Aldongarovna ,   Toraighyrov University
Published: October 2022

Introduction. The article is devoted to the study of the problem of increasing students’ positive motivation for and interest in entrepreneurship. The purpose of the study is to evaluate and substantiate the effectiveness of cognitive-economic subjectivity of individual’s development in the formation of positive motivation for entrepreneurship. Materials and Methods. The theoretical basis of the study is the philosophy of holism. Therefore, the system-synergetic and transdisciplinary principles were used to solve the problems and to develop integrated didactic content. The ascertaining and forming stages of the educational experiment were carried out, and experimental methods of educational research and methods of mathematical statistics for processing empirical data (Wilcoxon test) were applied. Results. The article explores the effectiveness of initial preparation of students for business. The effectiveness of applying systemic-synergetic and transdisciplinary principles to the development of integrated content in physics and the basics of Economics is justified. The formation of students' cognitive-economic subjectivity, which characterizes the level of the motivational-need stage of students' readiness for entrepreneurship, is clarified. At the same time, the level of task performance indicates the formation of students’ cognitive-economic motivation for entrepreneurship. The concept of holism made it possible, on the basis of the system-synergetic principle, to single out the property of coherence of the studied independently known concepts of ‘cognitive subjectivity’ and ‘economic subjectivity’ and to prove their emergence. At the same time, cognition indicates a conscious knowledge-oriented level of practical actions of an entrepreneur, and the economic component indicates their pragmatic orientation of thinking and actions. Conclusions. The experimental study revealed the effectiveness of applying the didactic content of the specialized course of entrepreneurial education for the development of the business sector.
The shift in the translation of Japanese compound sentences into Indonesian in the novel Tokyo Tower by Lily Franky
Authors: Fitriani Laily , Haristiani Nuria , Sutedi Dedi
Published: October 2022

Indonesian sentence structure with a subject-verb-object pattern differs from Japanese sentence structure with a subject-object-verb pattern. This significant difference in grammatical structure often creates difficulties in translating Japanese into Indonesian, especially in translating written texts with long or compound sentences. This article tries to analyze the translation of Japanese compound sentences into Indonesian from the aspect of translation shift. This study will explain the shift in translating Japanese compound sentences into Indonesian. This research is a qualitative descriptive study. The data sources of this research were taken from the Japanese novel Tokyo Tower by Lily Franky and the Indonesian translation of the novel with the same title. The result is 270 compound sentences as finding data. This study analyzes compound sentence data using translation shift theory according to Catford (1965), which is classified into six types: a level shift from lexical level to grammatical level, a level shift from grammatical level to lexical level, a structure shift, a class shift, a unit shift, and intrasystem shifts. The shift in structure is a definite thing because of the differences in the sentence structure between Japanese and Indonesian, especially in the translation of compound sentences.
The Implementation of Non-Refoulement Principle in Case of Rohingnya
Authors: Utami Mumpuni Tri
Published: October 2022

The principle of non-refoulement is a refugee protection framework that prohibits the recipient country to expel the individual concerned to the area where he will experience persecution. Along with developments in international human rights law, the principle of non-refoulement is used as a method of fulfilling and protecting rights that are not interrogated, one of which is the right to be free from torture, cruel, inhuman and degrading behavior. This makes the principle of non-refoulement often applied without exception and discussed to achieve the status of jus cogen, the highest norm in the international legal hierarchy. The increase in asylum seekers is very worrying for the country of Indonesia, because Indonesia is not one of the countries ratifying the 1951 Refugee Convention, and has no obligation to accept asylum seekers, if asylum seekers enter illegally into Indonesia, and can disrupt the stability of Indonesia's defense and security . In general, the state is not asked to allow foreigners to enter its territory, but refugees are an exception to that rule. Refugees are people who are in a very vulnerable situation. They do not get protection from their own country, even often the government itself threatens to persecute them. In such circumstances, the international community makes the necessary efforts to guarantee and ensure that a person's basic rights remain protected and respected. In this international protection status, a person who is in a capacity as a refugee is obliged to get protection for his basic human rights. Rohingya ethnic refugees without citizenship are one example. Torture and discrimination have made them inevitably leave their home countries for centuries. Many of them fled to countries like Indonesia. However, it should be remembered that Indonesia did not ratify the 1956 convention or the 1967 protocol. However, the existence of the principle of non-refoulement caused Indonesia to accept and protect the Rohingya refugees.
Penyelesaian Sengketa Pencemaran Laut Timor Akibat Kebocoran Sumur Minyak Montara Australia Antara Indonesia dan Australia
Authors: Ambarwati Maya Dwi
Published: October 2022

This paper analyze the resolution of the Montara oil spill dispute between Indonesia and Australia. Analyze the responsibility of the Australian state for Timor Sea pollution due to the Montara oil leak. The analysis uses normative legal research using a statutory approach (statue approach), a conceptual approach, and a case approach. Whereas the settlement of the Montara oil spill dispute between Indonesia and Australia used a negotiation method whereby the Indonesian state filed a claim against Australia and demanded compensation for the effects of the oil spill, but Australia rejected the negotiations and the negotiations were unsuccessful. The form of responsibility of the Australian state is absolute, but in reality, if the responsibility seen or carried out is not in accordance with UNCLOS III 1982 because the Australian state is a drilling country carried out then giving permission to Thai companies in the ZEE region of the country.
The Territorial Limitation Dispute and Its Settlement Between Peru and Chile
Authors: Rosita Fitria Ida
Published: October 2022

In a country usually consists of an area in the form of land, an area in the form of oceans, and airspace. Sometimes these areas must be directly adjacent to other areas of the country, with this the State should have responsibility regarding the boundaries of its country to determine and claim that the position and boundaries are the property of its country, and are required to register the territory with the United Nations. The sea border dispute that occurred between Chile and Peru began when the two countries were adjoining territories after Bovilia surrendered its maritime territory to Chile resulting from losing the Pacific War in 1883. Then in 1947 Peru and Chile stated in their own way that sovereignty over the sea, which is 200 miles along the coast of each of the Chilean and Peruvian countries. The Peruvian president denies that the maritime zone between Chile and Peru has never been based on legal agreements. But on the other hand Chile claims that both parties have agreed to limits in the sea zone measured from the shoreline that runs along parallel latitudes
Analisa Terhadap Pemberian Nafkah Bekas Istri dalam Studi Kasus Putusan Pengadilan Negeri Tangerang Nomor : 927/PDT.G/2017/PN.TNG
Authors: Widodo Ragil
Published: October 2022

Pemberian Nafkah terhadap bekas Istri pasca Perceraian menjadi hal yang sangat menarik untuk dibahas salah satunya sebagaimana dalam putusan Pengadilan Negeri Tangerang Nomor: 927/Pdt.G/2017/PN.Tng tentang perkara perdata gugatan perceraian. Yang dalam amar putusannya menyatakan bahwa: “Menghukum Tergugat Rekonvensi / Penggugat Konvensi untuk memberikan nafkah setiap bulan kepada Penggugat Rekonpensi / Tergugat Konvensi sebesar Rp. 17.500.000,- (tujuh belas juta lima ratus ribu rupiah) sampai dengan Penggugat Rekonvensi / Tergugat konvesi menikah lagi”. Penulis dalam hal metode penelitian menggunakan metode penelitian normatif, dengan pendekatan yuridis normatif.  Bahwa hakim dalam pertimbangan putusan mengacu pada ketentuan pasal 41 Undang-undang No.1 tahun 1974, namun tidak memberikan suatu alasan-alasan hukum sama sekali dalam pertimbangan hukumnya sehingga Majelis Hakim terbukti tidak memiliki alasan-alasan hukum terkait dengan fakta-fakta dalam perkara a quo yang menjadikan dasar bagi Majelis Hakim dalam menerapkan 41 huruf (c) Undang-undang No.1 tahun 1974 tentang Perkawinan yang tidak bersifat imperatif tersebut. Sehingga perlu adanya kehati-hatian, keadilan dan berlandasan hukum untuk memutus suatu perkara sehingga tidak menjadikan putusan yang sumir atau bahkan menjadi rancu dan ambigu dalam menjalankan implementasi sebuah putusan pengadilan.
Strategi Dalam Pemberantasan Tindak Pidana Korupsi di Lingkungan PT Waskita Karya
Authors: Aqil Nabil Abduh
Published: October 2022

State-Owned Enterprises as a government tool in seeking profit in running their business in managing funds from capital receipts from the government have a great potential for corrupt practices. Therefore, PT Waskita Karya in suppressing and taking preventive steps for corruption by implementing preventive efforts in preventing at Waskita Karya Group with a Situational Prevention Crime approach that focuses on internal and external supervision and narrows space in areas prone to corruption. Then improve the quality of human resources with integrity and quality. In addition to a preventive approach, a repressive approach by taking an approach that focuses on asset recovery due to losses from corruption through one of the civil law instruments, civil forfeiture as regulated in the Anti-Corruption Law.
The Legal Protection of Prisoners with Disabilities in Class IIA Prison of Pekalongan
Authors: Ashraff Mohamad , Subroto Mitro
Published: October 2022

Security Protection of Prisoners Persons with Disabilities have not been regulated in Law Number 12 of 1995 concerning Corrections, but Law Number 8 of 2016 concerning Persons with Disabilities regulates the Guarantee of Protection for Prisoners with Disabilities. The problem in this research is how is the juridical point of view on the guarantee of protection for prisoners with disabilities at the Class IIA prison in Pekalongan, and how is the guarantee of protection for prisoners with disabilities in the future. The purpose of this study was to determine the guarantee of protection for prisoners with disabilities in Class IIA prison in Pekalongan and the guarantee of protection for prisoners with disabilities in the future. The research that uses the type of legal research used is sociological juridical, the research specifications used are analytical descriptive, the data collection method used is primary data and secondary data, and the data analysis used is qualitative. This research can result that the Protection Guarantee for Prisoners with Disabilities has not been regulated in Law Number 12 of 1995 concerning Corrections but in fact the Protection Guarantee has been applied to Class IIA prison in Pekalongan and the Draft Law on Corrections which is the drafting process should regulate the Protection Guarantee against prisoners with disabilities.
Shareholders Lawsuit: Fraud on Minority Law Enforcement to Invent Corrective Justice During the Covid-19
Authors: Yusro Mochammad Abizar
Published: October 2022

The purpose of this study is to analyse and provide recommendations for national law, related to law enforcement in violations against minorities (fraud on minorities) shareholders to create corrective justice during the covid-19 period. Minority Shareholders are a group that is classified as vulnerable to actions that can result in losses. For this reason, law enforcement efforts against Minority Shareholder fraud are needed, to provide legal protection and recovery of losses in order to create corrective justice. This research method is descriptive by using the type of juridical-normative research. The type of approach used is a statutory approach and a conceptual approach. The results of this study describe the rights of shareholders given by laws and regulations, which can be used to carry out legal remedies based on corrective justice when fraud is on a minority. The legal effort began with a shareholder lawsuit consisting of two mechanisms, namely derivative action and direct action from shareholders which has been accommodated in Law Number 40 of 2007 concerning Limited Liability Companies. However, this effort is commonly used and has several weaknesses, one of which is the absence of specification rules related to the procedures for implementing it.
Identification of a novel specific small-molecule melanocortin-2-receptor antagonist
Authors: Forfar Rachel , Hussain Mashal , Khurana Puneet , Cook Jennifer , Lewis Steve , Popat Dillon , Jackson David , McIver Ed , Jerman Jeff , Taylor Debra , Clark Adrian JL , Chan Li F
Published: October 2022

The overproduction of adrenocorticotropic hormone (ACTH), in conditions such as Cushing’s disease and congenital adrenal hyperplasia (CAH), leads to significant morbidity. Current treatment with glucocorticoids does not adequately suppress plasma ACTH, resulting in excess adrenal androgen production. At present, there is no effective medical treatment in clinical use that would directly block the action of ACTH. Such a therapy would be of great clinical value. ACTH acts via a highly selective receptor, the melanocortin-2 receptor (MC2R) associated with its accessory protein MRAP. ACTH is the only known naturally occurring agonist for this receptor. This lack of redundancy and the high degree of ligand specificity suggest that antagonism of this receptor could provide a useful therapeutic strategy in the treatment of conditions of ACTH excess. To this end, we screened an extensive library of low-molecular-weight drug-like compounds for MC2R antagonist activity using a high-throughput homogeneous time-resolved fluorescence cAMP assay in Chinese hamster ovary cells stably co-expressing human MC2R and MRAP. Hits that demonstrated MC2R antagonist properties were counter-screened against the β2 adrenergic receptor and dose–response analysis undertaken. This led to the identification of a highly specific MC2R antagonist capable of antagonising ACTH-induced progesterone release in murine Y-1 adrenal cells and having selectivity for MC2R amongst the human melanocortin receptors. This work provides a foundation for the clinical investigation of small-molecule ACTH antagonists as therapeutic agents and proof of concept for the screening and discovery of such compounds.
KEBUTUHAN BUKU AJAR BAHASA SEJARAH SASTRA INDONESIA PERSPEKTIF ISLAM DI LINGKUNGAN PERGURUAN TINGGI ISLAM
Authors: Bahtiar Ahmad , Haryanti Novi Diah , Dipurnomo Nur Siswo
Published: October 2022

Abstrak: Distingsi Perguruan Tinggi Keagamaan Islam (PTKI)  dengan  perguruan tinggi lainnya adalah  integrasi keilmuan, keislaman, dan keindonesiaan. Ketiga hal tersebut harus dapat diimplementasikan dalam pembelajaran sehingga perlunya buku ajar sejarah sastra perspektif Islam di PTKI. Kajian  ini  menggunakan  penelitian dan pengembangan (Research and Developtment) dengan Teori Borg dan Gall untuk mengetahui kebutuhan tersebut. Data penelitian berupa hasil diskusi terpumpum (FGD) dan hasil angket yang diberikan kepada dosen dan mahasiswa PTKI serta guru. Hasil penelitian menunjukkan bahwa adanya kebutuhan buku ajar sejarah sastra Indonesia perspektif Islam. Buku ajar tersebut disusun secara kronologis dan tematik yang mencakup pengarang dan karyanya, persoalan Islam, peristiwa terkait Islam dan lembaga atau komunitas Islam.
To’on: Mitos Masyarakat Madura dalam Menghadapi Wabah
Authors: Fitriyah Atiqotul , Giriani Nella Putri , Kurniawan Muhammad Fadhly
Published: October 2022

ABSTRAKSejarah mengenai wabah yang dialami oleh masyarakat Madura ditandai dengan adanya kepercayaan mereka terhadap mitos To’on. Dari sekian banyaknya wabah yang merebak dalam sejarah peradaban masyarakat Madura, mereka hanya mengidentifikasi wabah tersebut sebagai wabah To’on. Keyakinan terhadap mitos To’on tersebut membuktikan bahwa masyarakat Madura tetap mempertahankan pewarisan cerita lisan antar generasi. Kepercayaan masyarakat Madura terhadap mitos To’on membuktikan bahwa aspek sosio-kultural lebih dipertimbangkan dibandingankan aspek kesehatan dalam menghadapi wabah. Penelitian ini dilakukan dengan tujuan untuk menjabarkan mitos tentang wabah yang diyakini oleh masyarakat Madura. Penelitian ini bertolak belakang dengan penelitian mengenai mitos yang dilakukan oleh beberapa peneliti terutama dari aspek kesehatan. Penelitian ini dilakukan dengan menggunakan metode kualitatif dengan pendekatan etnografi. Data dikumpulkan melalui wawancara mendalam terhadap narasumber terkait serta studi pustaka mengenai wabah. Langkah analisis dalam penelitian ini adalah 1) mengidentifikasi mitos To’on yang ada pada masyarakat Madura, 2) menganalisis mitos To’on dalam sejarah lisan masyarakat madura mengenai wabah, dan 3) mengungkap makna dan fungsi mitos To’on dalam masyarakat Madura dalam menghadapi wabah.
The Role of Perceived Organizational Support on Employee Turnover Intention
Authors: Khairina Nadia
Published: October 2022

Based on data obtained in 2016, it is known that at PT. X, the number of employees who made a turnover or changed jobs was 40 people or the equivalent of 25% of the total 135 employees at PT. X. Employees who have a high level of perception of organizational support will show high commitment and will not look for alternative jobs or have the desire to move out. As a result of previous research, perceived organizational support is one factor that reduces turnover intensity. This study recruited participants using a purposive sampling technique in which 55 men agreed to be participants. The analysis showcases a negative relationship between perceived organizational support and turnover intensity. The higher the perceived level of organizational support, the lower the turnover intensity behavior. Another finding is there is a 12.5% effect of perceived organizational support on turnover intention, which means that perceived organizational support is one of the main factors that directly affect turnover intention. This finding can be another evidence that perceived organizational support significantly affects turnover intention.
Empathy as a Mediator of the Effect of Dark Triad Personality, Social Support, and Demographic Factors on Cyberbullying Behavior in SMAN 10 Depok Students
Authors: Sari Bernianti Lingga , Andriani Yufi
Published: October 2022

This study examines empathy as a mediator of the dark triad personality, social support, and demographic factors on cyberbullying behavior in SMAN 10 Depok students. The study was conducted on 428 students of SMAN 10 with purposive sampling technique. The measuring tools used in this study are Tudkuea's Cyberbullying Scale, The Short Dark Triad (SD3), The Interpersonal Reactivity Index (IRI), and the Multidimensional Scale of Perceived Social Support (MSPSS). Data analysis using Path Analyze with MPlus 7.4 software. Based on the results of the analysis of the research data, a fit model was found so that it can be concluded that the theoretical model of Empathy as a mediator of the influence of dark triad personality, social support & demographic factors on cyberbullying behavior fits with empirical data. This means that Empathy acts as a mediator of the influence of dark triad personality, social support & demographic factors on cyberbullying behavior. Then the results of research data analysis related to direct influence reported that there was a significant effect of Machiavellianism and gender directly on cyberbullying, while narcissism, psychopathy, family support, peers support, and significant others had no significant effect on cyberbullying. In addition, the results of the hypothesis test also reported that there was a direct significant effect of narcissism, peers support and gender on Empathy, while there was no significant effect of psychopathic machiavellianism, family support and significant other (teachers) directly on Empathy.
Recovery from Long COVID: How College Students Thrive During Lockdown
Authors: Cabacungan Alisa Mar , Delima Klent Rodni Mundog , Mortiz Jo Niza Boldero , Paguta Loressa Joy De Claro , Billones Ruel
Published: October 2022

The Long COVID-19 Syndrome affected the lives of college students on lockdown for almost two years (2020-202), is the focus of this paper. Specifically, this study examined their stress, anxiety, depression levels, and psychosocial factors (socioeconomic status, adverse childhood experiences, and perceived social support) were related to these mental health issues. The impact of the Long COVID-19 on the students’ well- being and their coping mechanisms were explored. Using a cross- sectional survey research design, 600 students from different areas in Mindanao (southern islands of the Philippines) participated in this study. Results showed that the majority of the respondents reported no stress (78%), no anxiety (38%), and no depression (44.80%) during the lockdown. Moreover, a significant positive relationship appeared between adverse childhood experiences (ACEs) and levels of stress (p <0.001), anxiety (p <0.001), and depression (p <0.001). These findings suggest that adverse childhood experiences increase and the risk of other mental health issues increases. Results also suggest a significant negative relationship between perceived social support and levels of stress (p <0.05) and depression (p <0.05). The intersection of learning in higher education and mental health suggests the correlates of stress, ACE, and anxiety.
Code Changes and Proposed Values for 2023
Authors:   American Academy of Pediatrics
Published: October 2022

This AAP Pediatric Coding Newsletter™ issue includes articles featuring some of the new and revised Current Procedural Terminology (CPT®) codes for 2023. Please note that codes and values are subject to change due to any late corrections or clarifications. All of the revisions to codes and guidelines for 2023 are applicable to services provided on and after January 1, 2023 (ie, changes are not applicable to services provided in 2022 even when reported in 2023).
Preparing for 2023: Outpatient Consultations
Authors:   American Academy of Pediatrics
Published: October 2022

This article reviews changes to codes and guidelines for reporting outpatient consultation services, including the following: Distinguishing consultations from other evaluation and management (E/M) servicesCode selection based on medical decision-making (MDM) or the total time directed to the patient’s care on the date of the encounterCodes reported to payers that do not pay for services reported with codes for consultation services
Preparing for 2023: Emergency Department Visits
Authors:   American Academy of Pediatrics
Published: October 2022

This article reviews changes to codes and guidelines for reporting evaluation and management (E/M) services provided to patients in an emergency department (ED), including the following: How codes are changingCode selection based on medical decision-making (MDM) aloneReporting ED E/M and critical care services on the same dateObservation services provided in the ED
Juventude e acesso ao ensino superior: sobre o não lugar de vestibulando
Authors: Senkevics Adriano Souza , Carvalho Marília Pinto de
Published: October 2022

O texto objetiva entender os desafios e as perspectivas de jovens de camadas populares sobre a transição para o ensino superior. Baseia-se em um trabalho de campo realizado em Brasília/DF no ano de 2018 que contou com a aplicação de mais de duzentos questionários em cursinhos pré-vestibulares comunitários e entrevistas com vinte vestibulandos. Os resultados indicam a existência de um não lugar de vestibulando caracterizado pela ausência de vínculos entre os indivíduos e as instituições de ensino ou de trabalho. Há uma fricção entre lógicas de ação que se encontram e se combinam contraditoriamente nas falas dos jovens: ora percebe-se o ensino superior como uma vocação a ser reivindicada pelo esforço, ora como uma entre outras oportunidades a se “correr atrás”. De um lado, perspectivas meritocráticas estimulam os jovens a investirem em opções de cursos, carreiras e instituições mais ousados, alegadamente relacionados à sua vocação pessoal; de outro lado, os sucessivos fracassos nas tentativas de transição ou as dificuldades prévias em suas trajetórias escolares os forçam a optarem por caminhos mais pragmáticos, reproduzindo lógicas de “viração” que marcam suas experiências para além do campo educacional. Essa discussão elucida de que forma o processo de expansão respondeu por uma alteração na maneira pela qual o próprio acesso à educação é entendido.
XBP1 Activation Reduces Severity of Polycystic Kidney Disease due to a Nontruncating Polycystin-1 Mutation in Mice
Authors: Krappitz Matteus , Bhardwaj Rishi , Dong Ke , Staudner Tobias , Yilmaz Duygu Elif , Pioppini Carlotta , Westergerling Parisa , Ruemmele David , Hollmann Till , Nguyen Thuy Anh , Cai Yiqiang , Gallagher Anna-Rachel , Somlo Stefan , Fedeles Sorin
Published: October 2022

Significance Statement

XBP1 activation in neonatal and adult doxycycline-inducible murine models of ADPKD due to a hypomorphic polycystin-1 missense mutation orthologous to human PC1R2220W delays cyst formation. Activating XBP1s, a pro-chaperone inducer of the endoplasmic reticulum stress response, can improve steady-state expression, ciliary trafficking, and cleavage of the mutant protein, providing initial in vivo proof of concept that modulating levels of poorly functioning hypomorphic PC1 alleles can slow progression of kidney cyst formation in ADPKD.

Background

Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in Pkd1 and Pkd2. They encode the polytopic integral membrane proteins polycystin-1 (PC1) and polycystin-2 (PC2), respectively, which are expressed on primary cilia. Formation of kidney cysts in ADPKD starts when a somatic second hit mechanism inactivates the wild-type Pkd allele. Approximately one quarter of families with ADPDK due to Pkd1 have germline nonsynonymous amino acid substitution (missense) mutations. A subset of these mutations is hypomorphic, retaining some residual PC1 function. Previous studies have shown that the highly conserved Ire1α-XBP1 pathway of the unfolded protein response can modulate levels of functional PC1 in the presence of mutations in genes required for post-translational maturation of integral membrane proteins. We examine how activity of the endoplasmic reticulum chaperone-inducing transcription factor XBP1 affects ADPKD in a murine model with missense Pkd1.

Methods

We engineered a Pkd1 REJ domain missense murine model, Pkd1R2216W
, on the basis of the orthologous human hypomorphic allele Pkd1R2220W
, and examined the effects of transgenic activation of XBP1 on ADPKD progression.

Results

Expression of active XBP1 in cultured cells bearing PC1R2216W mutations increased levels and ciliary trafficking of PC1R2216W. Mice homozygous for Pkd1R2216W
or heterozygous for Pkd1R2216W

in trans with a conditional Pkd1fl
allele exhibit severe ADPKD following inactivation in neonates or adults. Transgenic expression of spliced XBP1 in tubule segments destined to form cysts reduced cell proliferation and improved Pkd progression, according to structural and functional parameters.

Conclusions

Modulating ER chaperone function through XBP1 activity improved Pkd in a murine model of PC1, suggesting therapeutic targeting of hypomorphic mutations.
Thermal conductivity of single crystals zirconia stabilized by scandium, yttrium, gadolinium, and ytterbium oxides
Authors: Agarkov D. A. , Borik M. A. , Korableva G. M. , Kulebyakin A. V. , Lomonova E. E. , Milovich F. O. , Myzina V. A. , Popov P. A. , Tabachkova N. Yu.
Published: October 2022

The phase composition and heat conductivity of (ZrO2)0.9(R2O3)0.1 solid solution single crystals have been studied, where R = (Gd, Yb, Sc, Y), (ZrO2)0.9(Sc2O3)0.09(Gd2O3)0.01 and (ZrO2)0.9(Sc2O3)0.09(Yb2O3)0.01. Single crystals have been grown by directional melt crystallization in a cold skull. The phase composition of the crystals has been studied using X-ray diffraction and Raman spectroscopy. The heat conductivity of the crystals has been studied using the absolute steady-state technique of longitudinal heat flow in the 50—300 K range. We show that at a total stabilizing oxide concentration of 10 mol.% the phase composition of the crystals depends on the ionic radius of the stabilizing cation. The (ZrO2)0.9(Sc2O3)0.1 crystals have the lowest heat conductivity in the 50—300 K range while the (ZrO2)0.9(Gd2O3)0.1 solid solutions have the lowest heat conductivity at 300 K.Analysis of the experimental data suggests that the heat conductivity of the crystals depends mainly on the phase composition and ionic radius of the stabilizing cation. Phonon scattering caused by the difference in the weight of the co-doping oxide cation has a smaller effect on the heat conductivity.
Vacuum as a continuum medium forming energy inhomogeneities with high energy density in the liquid phase
Authors: Sleptsov V. V. , Diteleva A. O. , Kukushkin D. Yu. , Tsyrkov R. A. , Diteleva E. O.
Published: October 2022

A method for the formation of metal nanoparticles in a localized volume with a high energy density due to the flow of a pulsed electric discharge and the effect of cavitation has been studied. The mechanism of formation of energy inhomogeneities, which provides the generation of nanoparticles with high specific energy intensity, is considered. The formation of dynamic heterogeneity is carried out in three stages. There is a breakdown of the interelectrode space and the formation of a vacuum volume, which is filled with a vapor-gas medium. As a result of an increase in pressure in the bubble, a pulsed gas discharge is ignited, which leads to the generation of metal nanoparticles. As a result, there is a localized volume in which the energy in the discharge reaches a value of up to 106 K. The growth of energy in the bubble leads to its collapse and metal nanoparticles pass from a medium with high energy (106) into water at room temperature, which leads to their hardening. Particularly pure nanoparticles of various metals with a size of 5–15 nm are obtained, which can be grown on a single-crystal silicon surface at room temperature and positioned on the surface of porous materials and products of complex configuration.
Primer registro del género Tikuna Savage, Flowers y Porras (EPHEMEROPTERA: LEPTOPHLEBIIDAE) para el Chocó, Colombia
Authors: Mosquera Murillo Zuleyma , Córdoba Aragón Karen E.
Published: October 2022

En este artículo se presenta por primera vez el registro del género Tikuna (Ephemeroptera: Leptophlebiidae) para el departamento del Chocó y segundo para Colombia. El registro se basa en ninfas colectadas en tres pequeñas quebradas de los municipios de Quibdó y Unión Panamericana; caracterizadas por presentar aguas trasparentes, corriente moderada, fondo arenoso y abundante vegetación ribereña. Los ejemplares se encuentran depositados en la Colección Limnológica del Chocó (CLCH-Insec).
Coccinélidos depredadores de Crypticerya multicicatrices (HEMIPTERA: MONOPHLEBIDAE) en San Andrés Isla, Colombia
Authors: Silva Gómez Marcela , Quiroz Gamboa John Alveiro , Hoyos Carvajal Lilliana María , Yepes R. Francisco Cristóbal , Maya A. María Fernanda , Santos M. Adriana
Published: October 2022

Se realiza la identificación y primer reporte de los coccinélidos Anovia punica Gordon, 1972, Cryptognatha auriculata Mulsant, 1850 y Zagloba beaumonti Casey, 1899 (Coleoptera: Coccinellidae), durante la evaluación realizada para el reconocimiento de depredadores de Crypticerya multicicatrices Kondo y Unruh, 2009 (Hemiptera: Monophlebidae) en Coco (Cocos nucifera) y limón (Citrus limon), hallados en la isla de San Andrés (Colombia), en muestreos llevados a cabo entre agosto y noviembre de 2012.
Primer registro de Notiobia (Notiobia) umbrifera Bates y redescubrimiento de Notiobia (Anisotarsus) praeclara Putzeys (COLEOPTERA: CARABIDAE) en Colombia
Authors: Arenas Clavijo Anderson
Published: October 2022

Se aporta información sobre la distribución geográfica de dos especies de Notiobia Perty, 1830, en Colombia; se encontraron especímenes Notiobia (Notiobia) umbrifera, así como especímenes de Notiobia (Anisotarsus) praeclara. Este último fue hallado 115 años después de su descripción. Los especímenes registrados se encontraron asociados a coberturas boscosas del Suroccidente colombiano.
Análisis fisicoquímico y biológico del río santo domingo, afluente Río Verde, cuenca del río La Vieja, Alto Cauca, Colombia
Authors: García Alzate Carlos A. , Villegas Acosta Paola A. , Román Valencia César
Published: October 2022

Se realizó un análisis fisicoquímico y biológico del río Santo Domingo, afluente río Verde, cuenca río La Vieja, Alto Cauca, Colombia, en 12 estaciones de muestreo durante bajas (febrero, junio y julio) y altas lluvias (abril, marzo y mayo). Se aplicaron índices de diversidad alfa como Shannon-Wiener, Dominancia, Margalef y Pielou; diversidad beta con Jaccard y diversidad gamma Schluter-Ricklefs y BMWP/Col para estimar la calidad del agua. El ANDEVA mostró diferencias significativas entre las épocas de lluvia para el oxígeno disuelto, el pH, la conductividad y la humedad relativa. Se registraron en total 12405 ejemplares de macroinvertebrados: 8177 en bajas y 4228 en altas lluvias; Ephemeroptera fue el orden más abundante para ambas épocas con el género Baetodes; el ANDEVA de dos factores mostró significancia de la abundancia absoluta entre épocas y zonas; el BMWP/Col indicó que la calidad del agua fue buena, a excepción de la estación 3 que presentó una calidad aceptable. Se capturaron 97 ejemplares de peces: 70 para bajas y 27 para altas lluvias; las especies de peces más abundantes fueron Astroblepus chapmani y Brycon henni. Los índices de diversidad y riqueza fueron bajos para las comunidades de macroinvertebrados y peces. La diversidad gamma para macroinvertebrados y peces fue consistente con el número de especies encontradas en el estudio. El río es oligotrófico, con tendencia a la eutroficación en ambos periodos climáticos.
Registro confirmado de Cyclopes Didactylus (PILOSA: CYCLOPEDIDAE) para el departamento de Risaralda, Colombia
Authors: Cepeda D. Juan C. , Chacón P. Julio
Published: October 2022

El hormiguero de seda (Cyclopes didactylus) presenta vacíos en Colombia sobre aspectos de su ecología básica, por lo que es necesario ampliar los registros en diferentes localidades del país. Este trabajo brinda el primer registro confirmado de la especie para el departamento de Risaralda, Colombia, con anotaciones de su presencia en un área periurbana.
Catálogo de la flora (Angiospermas) del páramo de Bijagual, Boyacá, Colombia
Authors: Carrillo Fajardo Merly Yenedith , Morales Puentes María Eugenia , Gil Leguizamón Pablo Andrés
Published: October 2022

Se elaboró un catálogo de las angiospermas del páramo de Bijagual con información de las especies, distribución local y nacional. Se registraron 35 familias, 73 géneros y 120 especies.
Nuevo registro de Coryphorus (INSECTA: EPHEMEROPTERA) y notas adicionales sobre su morfología
Authors: Cárdenas López Tatiana , Ospina Londoño Ximena , Rodríguez Zambrano Miguel , Rozo María Paula , Romero Zúñiga Rodrigo Iván , Gomes Dias Lucimar
Published: October 2022

Se presenta la distribución actual de la familia Coryphoridae con dos nuevos registros del género Coryphorus para el departamento del Putumayo, Colombia. Adicionalmente, se muestran detalles de las espinas y setas de las ninfas mediante microscopía electrónica (SEM), y se describen variaciones morfológicas de la genitalia del adulto.
Distribución potencial de Oxysternon conspicillatum (Weber, 1801) en diferentes escenarios de cambio climático en Colombia
Authors: Martínez Quintero Bedir Germán , Echeverri Rubio Alejandro , Gaviria Ortiz Fabián Guillermo
Published: October 2022

Los escenarios de cambio climático son herramientas útiles para la evaluación de impactos, iniciativas de adaptación y mitigación, y creación de modelos climáticos; estos se proyectan en el tiempo para predecir la unidad de hábitat en que se encuentran las especies. Adicionalmente, los modelos de distribución de especies estiman el área de ocupación de un organismo con potencial bioindicador como los escarabajos coprófagos, entre ellos la especie Oxysternon conspicillatum con amplia distribución geográfica en Colombia. El propósito de este trabajo fue determinar la distribución potencial de O. conspicillatum en un escenario pesimista (A2) y uno optimista (B1) de cambio climático en Colombia para los años 2050 y 2080. Para el desarrollo del modelo se recolectó información publicada y/o depositada en diferentes colecciones del país, de manera tal que se obtuvieron 427 registros, distribuidos en 11 fuentes de información. La especie se registró en 18 departamentos, donde el Eje Cafetero fue el que presentó mayor disponibilidad de datos geográficos. Se encontró que la probabilidad de ocupación de O. conspicillatum en la Cordillera Oriental disminuye drásticamente para estos dos años. Este resultado concuerda con lo observado en otros grupos bioindicadores como las plantas y las mariposas. O. conspicillatum es una especie ampliamente distribuida en Colombia, sin embargo, para los años 2050 y 2080 bajo dos escenarios de cambio climático (A2 y B1) presentará una disminución considerable de su presencia a nivel nacional.
New species of the genus Trigonospila Pokorny (DIPTERA: TACHINIDAE) parasitises adult Compsus sp. schoenherr (COLEOPTERA: CURCULIONIDAE) in Colombia
Authors: Vinasco Natalia , Vallejo Luis Fernando , Soto Alberto
Published: October 2022

Trigonospila unicaldasi new specie, is described for the first time for science. In order to differentiate it from other rarely occurring species in the Americas, key characteristics of the adult were identified through scanning electron microscopy. The species was found parasitising adult weevils of the genus Compsus sp. (Coleoptera: Curculionidae) associated with citrus crops in the central coffee-growing region of Colombia. The interesting symbiotic phenomenon of control described in this paper is considered unusual in the biology of Tachinidae given that only 5-10% of the family parasitise their hosts at the adults stage.
Primer registro de Hydnopolyporus fimbriatus (COOKE) D.A. Reid (POLYPORALES: MERIPILACEAE) para el departamento de Cundinamarca, Colombia
Authors: Castiblanco Z. Andrea , Pinzón O. César Augusto , Pinzón O. Jonás
Published: October 2022

Hydnopolyporus fimbriatus es un hongo lignícola reportado en Colombia por primera y última vez en 1930 para el departamento del Valle del Cauca. Durante un rastreo realizado en el campus de la Universidad Nacional de Colombia, sede Bogotá, se registró la presencia de la especie, con lo cual se expande su distribución para el departamento de Cundinamarca. Se recolectaron y examinaron 3 basidiomas siguiendo los protocolos establecidos en la literatura especializada. Se aporta información micológica sobre características macroscópicas y microscópicas, distribución actual, época de colecta y sustrato de crecimiento de los basidiomas.
Control alternativo de Diaphorina citri Kuwayama (HEMIPTERA: LIVIIDAE) utilizando caldo sulfocálcico
Authors: Restrepo García Ana María , Soto Giraldo Alberto
Published: October 2022

La concentración letal (CL) es usada para estimar la toxicidad de plaguicidas a artrópodos. Sin embargo, la CL es una medida incompleta de los efectos de los productos sobre poblaciones, pues analiza solamente la mortalidad como parámetro de toxicidad. Se sabe que individuos que sobreviven a la exposición a plaguicidas pueden sufrir efectos subletales. En este trabajo fue estudiado en laboratorio los efectos letales y subletales del caldo sulfocálcico en el crecimiento poblacional de Diaphorina citri. Los efectos letales fueron estimados a través de test de toxicidad aguda con obtención de curvas dosis-respuesta y sus respectivas concentraciones letales, y los efectos subletales a través de la estimativa de la tasa instantánea de crecimiento poblacional (ri). Las concentraciones letales y subletales del caldo sulfocálcico para D. citri fueron de 0,57 y 0,38% del producto, respectivamente, lo que indica que podría utilizarse para el control del fitófago.
Biología reproductiva de Sicalis flaveola (AVES: THRAUPIDAE) en Cali, Colombia
Authors: Espinosa Camilo , Cruz Bernate Lorena , Barreto Guillermo
Published: October 2022

El Sicalis Coronado (Sicalis flaveola) es una especie principalmente granívora, común en hábitats abiertos, anidador secundario de cavidades y también usa nidos abandonados de otras especies. El conocimiento sobre la historia natural de la especie proviene principalmente de Argentina y Brasil; sin embargo, acerca de Sicalis flaveola flaveola distribuida en Colombia y Venezuela sólo se conocen algunos registros de tamaño de nidada. Entre enero de 2013 y mayo de 2015 se estudió la biología reproductiva de S. f. flaveola en el campus de Meléndez en la Universidad del Valle, Cali, Colombia. Se instalaron 94 cajas nido para propiciar mayor recurso de anidamiento y se hicieron cuatro recorridos semanales en busca de nidos activos y revisión de cajas nido. El tamaño de postura fue de 3,46 huevos, el promedio de polluelos que nacen es de tres con una proporción de sexo 1:1. La incubación estuvo a cargo de la hembra mientras el cuidado de los polluelos fue efectuado por ambos miembros de la pareja. El éxito reproductivo de la especie al momento de abandonar el nido fue de 65,8%. Se encontraron diferencias con las subespecies de las latitudes del sur de Suramérica, con un menor rango de tamaño de postura y con períodos más largos de incubación y permanencia de polluelos en el nido. Sin embargo, en aspectos como el cuidado paternal durante la incubación y el cubrimiento de los polluelos, son similares.
Bird assemble associated to two landscape units in a tropical dry forest
Authors: Sánchez Montenegro Juan Pablo , Pérez Castillo Katherine , Garcés Restrepo Mario Fernando , Giraldo Alan
Published: October 2022

The transformation of ecosystems through human activities can affect the biological and ecological processes of bird species, and can even lead to groups of species becoming isolated due to deforestation, causing a decrease in genetic diversity and the extirpation of species. To evaluate the composition and structure of bird communities associated with the tropical dry forest ecosystem in the Guarinocito jurisdiction (La Victoria, Caldas) we identified two landscape units: a forest area (dry forest matrix) and an interfered area (matrix of lands), presenting human intervention such as roads and grassland systems. Point counts of 10 min long were carried out in each unit to survey birds between 06:00 and 09:00 hours and between 16:00 and 18:00 hours. Mist nets were set up to complete the species record. Three four-day long sampling trips were carried out in April 2013, November 2013, and October 2014 to consider the seasonal variability that affects the environmental conditions in the study area. The sampling representativeness was evaluated using non-parametric estimates. All observed or captured individuals were assigned to a trophic guild in order to evaluate the community structure in the two established landscape units. A total of 1,005 individuals from 36 families and 127 species were recorded. The most abundant species were Thraupis episcopus (7.36%) and Sicalis flaveola (6.77%). Sample representativeness ranged from 68.18% (Jack 2) to 86.03% (Bootstrap). Although no significant differences between the two landscape units were detected (THutchinson=1.59, p=0.81), species diversity was higher in the forested area than in the intervened area. The dominant trophic guild in both landscape units was that of insectivorous birds. No significant differences in bird community trophic structure were found between the two landscape units (X 2 =14.60, p=0.33). The size, shape, or intervention history of the fragments could have resulted in a lack of differences in the structure and composition of the avifauna in the two landscape units.