bluuebunny/crossref_metadata_2025 huggingface dataset:
The Synthesis and Evaluation of Non-steroidal Antiinflammatory Activity of N,6-diaryl-4-methyl-2-thioxo-1,2,3,6-tetrahydropyrimidine-5-carboxamides
Authors: Buzmakova N. A. , Rudakova I. P. , Zamaraeva T. M. , Dozmorova N. V. , Slepova N. V.
Published: December 2022

Introduction.New potential biologically active compounds with different pharmacological activities were found among pyrimidine derivatives. Simple and available synthesis of tetrahydropyrimidine-5-carboxamides was developed in Perm State Pharmaceutical Academy. Products of this reaction previously shown high analgesic and anti-inflammatory activities.

Aim.To get previously unknown functionalized pyrimidines and to study their analgesic, anti-inflammatory and antipyretic activities.

Materials and methods.11 compoundsN,6-diaryl-4-methyl-2-thioxo-1,2,3,6-tetrahydropyrimidine-5-carboxamides are objects of research. Their structure has been confirmed by spectroscopy methods. The biological activities were carried out by recommended methods for preclinical study of new pharmacological substances.

Results and discussion.This paper presents the results of preclinical tests of the obtained compounds.

Conclusion.Some compounds demonstrated high analgesic, anti-inflammatory and antipyretic activities and could be recommend for further study as perspective non-steroidal drugs.
Component Composition and Antimicrobial Activity of Fractions from the Aerial Part of Common Toadflax (Linaria vulgaris Mill.)
Authors: Bombela T. V. , Krotkova O. A. , Galishevskaya E. E. , Anisimova A. G. , Yagontseva T. A. , Agafontseva A. V. , Novikova V. V. , Whaley A. K. , Ponkratova A. O. , Luzhanin V. G.
Published: December 2022

Introduction. Natural biologically active substances (BAS) are distinguished by different polarity, which determines their physicochemical properties, including solubility. When using solvents of different polarity, it is possible to influence the spectrum of BAS extracted from plants, achieving their division into groups, and further achieving isolation in an individual form. Тhe aerial part of Linaria vulgaris Mill. (common toadflax) contains both lipophilic and hydrophilic substances. The herb L. vulgaris is widely used in folk medicine for treatment of angina, conjunctivitis, dermatomycosis, periodontitis and other diseases. Bacterial factors play an important role in the pathogenesis of these diseases.

Aim. To study the effect of solvents of different polarity on the component composition of extracted BAS and to study the antimicrobial activity of fractions from the herb L. vulgaris.

Materials and methods. The aerial part of L. vulgaris was collected at the flowering stage – at the beginning of fruiting stage in July 2021 in the Perm region. The fractions were obtained by sequential exhaustive liquid-liquid extraction of an alcoholic extract from the herb L. vulgaris with hexane, dichloromethane, and n-butanol. Detection of BAS was carried out by HPLC and planar chromatography on paper. Antimicrobial activity was studied against Escherichia coli, Staphylococcus aureus and Candida albicans.

Results and discussion. Using solvents of different polarity four fractions were obtained from the alcohol extract of L. vulgaris: hexane, dichloromethane, n-butanol and water. These fractions have differences in the composition of BAS. The number of polyphenolic substances in the fractions increases with increasing of solvent polarity: hexane (14), dichloromethane (55), butanol (61). The dichloromethane and n-butanol fractions have a similar composition, represented by polyphenolic compounds and iridoids. The main groups of compounds in these fractions are phenolic acids and flavonoids. Iridoids are found in trace amounts. In the hexane fraction, the smallest number of substances was found, iridoids are completely absent, and phenolic acids were found in trace amounts. The water fraction is characterized by the content of the entire BAS complex. The highest antibacterial activity against Escherichia coli and Staphylococcus aureus was found for the aqueous fraction, while the highest antifungal activity was found for the hexane and dichloromethane fractions.

Conclusion. Using solvents of different polarity, fractions containing a diverse set of BAS were obtained from the alcoholic extract of L. vulgaris. Fractions exhibiting different polarities from L. vulgaris have antimicrobial activity against Staphylococcus aureus and Escherichia coli, as well as against pathogenic fungi from the genus Candida.
Determination of Phytotechnological Parameters of the Dense Extract from Peach (Persica vulgaris) Leaves
Authors: Molokhova E. I. , Ivantsova L. V. , Belonogova V. D.
Published: December 2022

Introduction. Leaves of peach (Persica vulgaris), containing a large amount of biologically active substances, including flavonoids, are considered as promising plant source for producing extraction preparations.

Aim. The purpose of the study: to establish the influence of phytotechnological parameters for efficiency of isolation of complex of biologically active substances from peach leaves.

Materials and methods. The object of the study was samples of dried leaves of the cultivated peach tree – Persica vulgaris Mill. (Rosaceae family) collected during the growing season (at the end of August). The main technological parameters of vegetable raw materials were studied: average particle size and fractional composition, volume characteristics of specific, volume and bulk mass, porosity, porosity and free volume of the raw material layer, аs well as the absorption coefficient of the extractant.

Results and discussion. The obtained values of the fractional composition and volume characteristics indicate the expediency of using the maceration method in plant raw materials extraction. Experimental studies were carried out to select optimal modes of extraction of flavonoids from peach leaves (extractant, extraction temperature, extraction duration, degree of raw material grinding, hydromodule), which ensure high output of BAS complex into extract.

Conclusion. The study presents the analysis of phytotechnological parameters of peach leaves, a rational extraction method is justified – maceration at heating with periodic stirring, and extraction conditions are determined; providing maximum yield of active substances: temperature – 70 °С in 40 min, extractant – alcohol, ethyl solution 70 %, degree of raw material grinding – 2 mm, raw material : extractant ratio (1 : 10).
Study of the Influence of the Technological Regime of the Production of Water Extraction from Rosehip Fruits (Rosae fructus) on the Content of Ascorbic Acid
Authors: Sobin F. V. , Korosteleva L. K. , Lutkova T. A. , Dozmorova N. V.
Published: December 2022

Introduction. COVID-19 is recognized as the most significant pandemic of the modern era. Studies have shown the potential benefits of taking ascorbic acid in the complex treatment of this disease, especially in people with vitamin C deficiency. One of the most popular and affordable sources of ascorbic acid in the diet are rosehip fruits. The quality of water extracts from plant raw materials depends on a number of technological factors. The study of the influence of the technological regime of the production of water extraction from rosehip fruits on the release of ascorbic acid in the obtained dosage forms is relevant.

Aim. To obtain water extracts from rosehip fruits by various production modes and to study the effect of technological parameters on the content of ascorbic acid.

Materials and methods. The object of the study was rosehip fruits in bundles and water extracts based on them, obtained in the 6 different ways. Pharmacopoeial techniques, manufacturers' recommendations, as well as thermos infusion with and without preheating of the thermos flask were used. For quantitative determination of the ascorbic acid in the obtained aqueous extracts, we used the pharmacopoeia method (titration with 2,6-dichlorophenolindophenolate sodium).

Results and discussion. The lowest content of ascorbic acid was noted in the decoction according to the pharmacopoeia method. High levels of ascorbic acid content were noted in the variants of thermos infusion of rosehip fruits.

Conclusion. We have obtained extemporal water extracts of rosehip fruits by the 6 different extraction modes. According to the content of ascorbic acid, the most effective method of obtaining extemporal water extraction of rosehip fruits is a six-hour thermos infusion with preheating of the thermos flask. The largest amount of ascorbic acid is released during a six-hour thermos infusion. In the twelve-hour thermos infusions, a decrease in the amount of ascorbic acid was found. It was found that preheating the thermos flask leads to an increase in the yield of ascorbic acid in aqueous extraction by 25 %.
Chemical Analysis of the Main Groups of Biologically Active Substances in Sedative Collection
Authors: Zamakhaeva E. A. , Oleshko O. A. , Yaborova O. V. , Smirnova M. M.
Published: December 2022

Introduction. According to the World Health Organization, the number of patients with diseases of the nervous system in the world is increasing every year. The use of phytopreparations is a promising direction of pharmacotherapy; preparations from medicinal plant materials have a number of advantages in the treatment of chronic diseases.

Aim. Qualitative analysis and quantitative determination of the main groups of biologically active substances collected from medicinal plant materials.

Materials and methods. As an object of study, we used a collection of medicinal plant materials developed at the Department of Pharmaceutical Technology of the PSFA together with the Department of Pharmacognosy. Quantitative determination of biologically active substances of the collection was carried out by spectrophotometric method [Jenway PortLab 511 UV spectrophotometer PortLab Int., UK)] and by visual titration.

Results and discussion. In this work, a qualitative analysis and quantitative determination of the content of flavonoids, phenolic compounds, sesquiterpenic acids and ascorbic acid was carried out, and the water absorption coefficient of the collection was determined.

Conclusion. As a result of the work, the content of flavonoids, phenolic compounds, sesquiterpenic acids and ascorbic acid in the developed collection was confirmed, their amount was determined, which directly affects the pharmacological effect of the collection.
Seasonal Changes in the Sorption Activity of Water-soluble Polysaccharides in Scotch Pine Cones (Pinus sylvestris L.)
Authors: Gulyaev D. K. , Belonogova V. D.
Published: December 2022

Introduction. Currently, there is much tension around the issue of increasing the efficiency of use of forest resources. One of these resources are scotch pine cones, which remain at the felling areas. Polysaccharides of scotch pine cones have a significant sorption activity; however, it remains unclear does the month, when raw materials were collected, affect the sorption activity.

Aim. The research of the content, sorption activity and molecular weight of water-soluble polysaccharides of scotch pine cones in different seasons of the year.

Materials and methods. Water-soluble polysaccharide complex (WSPC) of scotch pine cones was obtained with a method based on the well-known scheme for the carbohydrates separation according to Bailey et al. WSPC was obtained from the samples of scotch pine cones collected from July till March. Determination of the content of scots pine cones WSPC was spectrophotometrically carried out, with the modified Draywood anthrone-sulfurous method. The sorption activity of polysaccharides was determined by the methylene blue. The molecular weight of polysaccharides was identified by the viscosimetric method.

Results and discussion. The content of WSPC in scotch pine cones from July till March was identified. The highest yield of WSPC was registered in winter (3.24 ± 0.31 %), and the lowest in summer (0.46 ± 0.01 %). The sorption activity of scotch pine cones WSPC in terms of methylene blue from July till March was researched in vitro. It was found that WSPC has the highest sorption activity in October (230.69 ± 4.18 %) and November (243.30 ± 9.43 %). The WSPC sorption activity is above the activity of standard medications: absorbent carbon (230.9 ± 2.34 mg/g) and colloidal silicon dioxide ("Рolisorb MP") (211.5 ± 1.87 mg/g). The average molecular weight of scotch pine cones WSPC from July till March was determined. The average molecular weight of WSPC is in the range from 6 872,27 to 21 598,06. The dependence of the scotch pine cones WSPC sorption activity on the molecular weight was registered.

Conclusion. The water-soluble polysaccharide complex of scotch pine cones, obtained at different seasons, has different sorption activity, which depends on a polysaccharide molecular weight. The highest content and sorption activity of scotch pine cones WSPC matches with the period of wood production, which stipulates a practical use of cones and directions for future research.
Leishmania Vaccines: the Current Situation with Its Promising Aspect for the Future
Authors: Dinc Rasit
Published: December 2022

Leishmaniasis is a serious parasitic disease caused by Leishmania spp. transmitted through sandfly bites. This disease is a major public health concern worldwide. It can occur in 3 different clinical forms: cutaneous, mucocutaneous, and visceral Leishmaniasis (CL, MCL, and VL, respectively), caused by different Leishmania spp. Currently, licensed vaccines are unavailable for the treatment of human Leishmaniasis. The treatment and prevention of this disease rely mainly on chemotherapeutics, which are highly toxic and have an increasing resistance problem. The development of a safe, effective, and affordable vaccine for all forms of vector-borne disease is urgently needed to block transmission of the parasite between the host and vector. Immunological mechanisms in the pathogenesis of Leishmaniasis are complex. IL-12-driven Th1-type immune response plays a crucial role in host protection. The essential purpose of vaccination is to establish a protective immune response. To date, numerous vaccine studies have been conducted using live/attenuated/killed parasites, fractionated parasites, subunits, recombinant or DNA technology, delivery systems, and chimeric peptides. Most of these studies were limited to animals. In addition, standardization has not been achieved in these studies due to the differences in the virulence dynamics of the Leishmania spp. and the feasibility of the adjuvants. More studies are needed to develop a safe and effective vaccine, which is the most promising approach against Leishmania infection.
Ectopic Schistosomiasis Involving Axillary Lymph Nodes
Authors: Chen Xia , He Nian’an
Published: December 2022

Axillary lymph node schistosomiasis is a form of ectopic schistosomiasis, in which the Schistosoma adult worms or eggs are infected in the axillary lymph nodes. A 53-year-old woman visited our hospital with a small mass in the right armpit, which had been present for over 1 month. Histological examination of biopsy samples from the right axillary lymph nodes revealed granulomas containing calcified Schistosoma eggs. This is the first authentic case of ectopic schistosomiasis identified in the axillary lymph nodes.
A Case of Ocular Sparganosis in China: Episode of Migration from Muscle Cone to Subconjunctiva
Authors: Chen Xinyuan , Fang Yanyuan , Tao Liming , Liu Miao , Liang Kun
Published: December 2022

To improve our understanding of the migration of sparganum in humans, we report a case of ocular sparganosis having the migratory episode from the muscle cone to the subconjunctiva. A 34-year-old woman was admitted to the Hospital of Anhui Medical University (Hefei, China), in December 2019. She presented with conjunctival hemorrhage and recurrent pain in the left eye. A foreign body was found in the muscle cone of the eye. Two months later, a ribbon-like white material was found under the conjunctiva on slit-lamp examination. A long and slender, actively moving parasite was extracted by surgery. The extracted worm was approximately 8 cm long and 2 mm wide. The worm was whitish, wrinkled, ribbon shaped, and had a slightly enlarged scolex. The worm sample was morphologically identified as a plerocercoid larva (sparganum) of the Spirometra tapeworm. Her conjunctival blood suffusion and eye pain ceased within 1 week after operation. She has been in good health without any symptoms during the 2-year follow-up. A case of ocular sparganosis, in which larval worm migrated from the muscle cone to the subconjunctiva is reported from China.
Liver transplantation for non-alcoholic fatty liver disease: indications and post-transplant management
Authors: Battistella Sara , D’Arcangelo Francesca , Grasso Marco , Zanetto Alberto , Gambato Martina , Germani Giacomo , Senzolo Marco , Russo Francesco Paolo , Burra Patrizia
Published: December 2022

Non-alcoholic fatty liver disease (NAFLD) is currently the fastest growing indication to liver transplantation (LT) in Western Countries, both for end stage liver disease and hepatocellular carcinoma. NAFLD/non-alcoholic steatohepatitis (NASH) is often expression of a systemic metabolic syndrome; therefore, NAFLD/NASH patients require a multidisciplinary approach for a proper pre-surgical evaluation, which is important to achieve a post-transplant outcome comparable to that of other indications to LT. NAFLD/NASH patients are also at higher risk of post-transplant cardiovascular events, diabetes, dyslipidemia, obesity, renal impairment and recurrent NASH. Lifestyle modifications, included diet and physical activity, are key to improve survival and quality of life after transplantation. A tailored immunosuppressive regimen may be proposed in selected patients. Development of new drugs for the treatment of recurrent NASH is awaited.
Manajemen Strategik Pembelajaran Pondok Pesantren dalam Mewujudkan Generasi yang Berakhlaqul Karimah
Authors: Eliyanto Eliyanto , Khurriyah Ummu
Published: December 2022

Penelitian ini dilatarbelakangi oleh pentingnya pondok pesantren dalam mewujudkan generasi yang berakhlakul karimah. Penelitian ini bertujuan untuk mengungkapkan manajemen strategik pembelajaran pondok pesantren dalam mewujudkan generasi yang berakhlakul karimah di Pondok Pesantren Al-Kamal Tambaksari Kecamatan Kuwarasan Kabupaten Kebumen. Pendekatan yang digunakan dalam penelitian ini adalah kualitatif studi kasus. Subjek penelitian ditentukan dengan teknik purposive sampling, yang terdiri atas Ketua Dewan Pimpinan Pondok Pesantren, Kepala Madrasah Diniyah Pondok Pesantren, dan Ustadz Madrasah Diniyah Pondok Pesantren. Data penelitian dikumpulkan melalui wawancara mendalam, observasi partisipan, dan analisis dokumen. Data penelitian ini dianalisis menggunakan teknik analisis interaktif yang dikembangkan oleh Miles & Huberman, yaitu: reduksi data, penyajian data, dan penarikan kesimpulan. Penelitian ini menunjukkan tiga tamuan. Pertama, Perencanaan strategik pembelajaran Pondok Pesantren dalam mewujudkan generasi berakhlaqul karimah di Pondok Pesantren Al-Kamal Tambaksari Kecamatan Kuwarasan Kabupaten Kebumen adalah dengan merumuskan setiap program yang ada, pimpinan pondok selalu merumuskan dan mengadakan musyawarah bersama dewan asatidz dan semua stakeholder yang ada untuk menyamakan visi, misi dan langkah-langkah dalam pencapaiannya. Kedua, Pelaksanaan strategik pembelajaran Pondok Pesantren dalam mewujudkan generasi yang berakhlaqul karimah di Pondok Pesantren Al-Kamal Tambaksari Kecamatan Kuwarasan Kabupaten Kebumen adalah dilaksanakan secara berjenjang dan terorganisir, selalu didampingi oleh pimpinan pondok, disurvei kegiatannya dan pendampingan yang intens, serta model kepemimpinan yang terbuka. Ketiga, Evaluasi strategik pembelajaran pondok pesantren dalam mewujudkan generasi yang berakhlaqul karimah di Pondok Pesantren Al-Kamal Tambaksari Kecamatan Kuwarasan Kabupaten Kebumen adalah dengan cara: (a) melihat secara langsung perilaku santri dalam kehidupan sehari-hari (amaliyah dzahiriyah); (b) evaluasi yang dilakukan secara formal maupun informal; (c) melihat secara langsung perubahan perilaku santri setelah mendapatkan pembinaan; (d) evaluasi yang dilakukan dalam kegiatan evaluasi mingguan, bulanan, semesteran, akhir tahun dan awal tahun; serta (e) evaluasi darurat.

Kata kunci: Manajemen Strategik, Pembelajaran, Pondok Pesantren, dan Generasi yang Berakhlakul Karimah.
Manajemen Blended Learning Nilai Agama dan Moral pada Masa Pandemi di RA Masyitoh Mertasinga Cilacap Utara Kabupaten Cilacap
Authors: Nurchasanah Nurchasanah
Published: December 2022

The  increasingly  widespread  spread  of  Covid  19  requires  that  learning  in  schools  be carried out online. However, there are several institutions that carry out blended learning, namely  carrying   out  limited   online   and   face-to-face   learning   such  as   RA   Masyitoh   Mertasinga. Formulation of the problem, first how to plan a blended learning of Religious and Moral Values at RA Masyitoh Mertasinga, secondly how to implement blended learning of Religious and Moral Values at RA Masyitoh Mertasinga and third how to evaluate the blended learning of Religious and Moral Values at RA Masyitoh Mertasinga.This  research  is  a  qualitative  research  because  it  produces  qualitative  data.  Collecting data  using  interviews,  observation  and  documentation.  Test  the  validity  of  the data  using triangulation techniques. Data analysis used description techniques with the Miles and Huberman  interaction analysis model with flows including data collection, data reduction, data presentation and drawing conclusions.The results of the study concluded, firstly the planning of blended learning on Religious and Moral Values at RA Masyitoh Mertasinga includes planning at the institutional level, namely preparing  blended  learning  supporting  facilities  and  infrastructure  and  planning  at  the  teacher level,  namely  setting  material,  setting  goals,  setting  strategies,  methods  and  media,  compiling a syllabus, establishing learning activities, planning evaluation and determining follow-up steps, the second is the implementation of blended learning, namely the delivery of material by the teacher to students through a series of activities to teach students actively, creatively, productively and fun by applying various strategies and methods and using media and teaching aids to achieve learning objectives and the third evaluation of blended learning includes evaluation of the implementation of blended learning and evaluation of student learning outcomes
Nilai-Nilai Islam Moderat dalam Pembelajaran PAI pada Masa Pandemi Covid19 Di SMK Negeri 1 Kebumen
Authors: Chamidi Agus Salim
Published: December 2022

Penelitian kualitatif ini bertujuan untuk mengetahui proses penanaman nilai-nilai Islam moderat dalam pembelajaran Pendidikan Agama Islam (PAI) pada Kelas X di SMK Negeri 1 Kebumen dan untuk mengetahui keberhasilannya. Pengumpulan data yang dilakukan melalui observasi, wawancara, dan dokumentasi dengan teknik analisa deskriptif-analitik. Informan penelitian adalah guru PAI Kelas X dan informan lain terkait. Penelitian dilakukan pada Agustus-Oktober 2020 di masa pandemi covid19. Hasil penelitian adalah bahwa: (1)di masa pandemi covid19 proses penanaman  nilai-nilai Islam moderat (wasathiyah) tentang al-adl (keadilan), al-tawazun (keseimbangan), dan al-tasamuh (toleransi) sudah baik dan tetap berlangsung dalam pembelajaran PAI Kelas X di SMK Negeri 1 Kebumen sesuai pedoman kurikulum yang diimbangi kreativitas guru dalam memasukkan konsep dan nilai-nilai tersebut sejak dari mulai pembuatan RPP sampai dengan proses evaluasi pembelajaran, (2)keberhasilan penanaman nilai-nilai Islam moderat tercermin dari hasil evaluasi belajar dan perilaku peserta didik Kelas X SMKN 1 Kebumen, dan hasilnya relatif sudah  baik.

Kata kunci: nilai Islam moderat, pembelajaran PAI
Pendekatan Inverse Action Research dalam Pengadaan Lahan Tanah di MWC NU Sruweng
Authors: Chamidi Agus Salim , Murtopo Bahrun Ali , Oktaviana Dewi
Published: December 2022

Artikel tentang riset berbasis pengabdian kepada masyarakat hasil kolaborasi dosen dengan mahasiswa KKN IAINU Kebumen 2021. Lokasi riset di Majelis Wakil Cabang Nahdlatul Ulama (MWCNU) Sruweng Kebumen. Tujuan riset untuk mengetahui proses transformasi sosial yang terjadi di MWCNU Sruweng dengan cara menelisik latar belakang dan tujuan yang ada di balik keberhasilan MWCNU Sruweng mengadakan lahan tanah milik MWCNU Sruweng, sekaligus mengetahui konsep dan nilai yang berada di baliknya. Riset bersifat kualitatif dengan model pendekatan riset aksi terbalik (inverse action research). Informan riset adalah sejumlah pengurus MWCNU Sruweng yang terlibat dalam pengadaan lahan tanah tersebut. Riset dilakukan pada bulan Agustus-September 2021. Hasil riset adalah: (a)model riset berhasil menggali latar belakang masalah dan tujuan dari pengadaan lahan tanah, (b)konsep utama pengadaan lahan tanah MWCNU Sruweng sebagai sarana fisik, yang kedepan akan dapat dibangun gedung MWCNU Sruweng untuk pengembangan kehidupan keagamaan warga NU di wilayah Sruweng, dalam rangka mencapai kesejahteraan masyarakat baik spiritual maupun material, (c)terdapat konsep dan nilai luhur bebasis budaya dan agama di balik pengadaan lahan tanah. Saran, bahwa model riset dan nilai yang berhasil didedah layak dimanfaatkan untuk keperluan melihat masyarakat masa kini, masa lalu, dan masa mendatangnya.
Implementasi Model Asset Based Community Development (ABCD) dalam Pendampingan Pemenuhan Kompetensi Leadership Pengurus MWC NU Adimulyo
Authors: Rinawati Atim , Arifah Umi , H Atik Faizul
Published: December 2022

This service activity aims to provide assistance in fulfilling the leadership competencies of MWC NU Adimulyo management, as well as carry out institutional self-evaluations related to fulfilling leadership competencies. In implementing this community service, the Assest Based Community Development (ABCD) method is used with 5 (five) stages of activity, namely discovery, dream, design, define, and destiny. The results of this activity were (1) The five stages were carried out through coordination and collaboration between students and MWC NU Adimulyo management under the guidance of Field Supervisors (DPL) (2) Community service activities resulted in improvements in fulfilling 4 (four) indicators of leadership competency assessment, namely preparation MWC NU conference, management recruitment mechanisms, leader competencies, and leadership strategies. Based on the institution's self-evaluation conducted, the leadership competence of MWC NU Adimulyo management was in the very good category with a score of 12.
Upaya Peningkatan Kedisiplinan Siswa melalui Pembelajaran Pendidikan Agama Islam di SMK Ma’arif 4 Kawedusan Kebumen
Authors: Makmun Syukron
Published: December 2022

The aim of the research to tell the efforts are made through the learning of Islamic Educational to improve the discipline of students in SMK MA’ARIF 4 Kawedusan Kebumen. This research is qualitative research whose data in the form of statements and documents. This research used a naturalistic approach to researching where natural (natural setting) and field (Field Research), to obtain the required data information researchers used the method of observation, interviews, and documentation. Analysis of the data is used in the form of triangulation analysis that includes data reduction, data presentation, and conclusion. The result of this research is found: 1) the discipline of students of SMK MA’ARIF 4 Kawedusan Kebumen has been good enough even though there are those who violate the rules. It still need to improve and reform the discipline of students so that they understand what is wrong even a little infractions. 2) The efforts of teacher to improve discipline students use the rules. For example, when there is student break the rule of school, especially PAI's teachers have to follow up violations that done by learners to give direction, motivation, giving punishment, or reward that is commensurate to what which is conducted.
Aksi Pembuatan Tata Tertib Kelas Untuk Perbaikan Mutu Madrasah Di MTs Khaudlul Ulum Penajung
Authors: Cahyani Aprilia Anggin
Published: December 2022

Student discipline in the classroom is an effort to build the character of student discipline. However, in general the rules are made not too heeded the students so that gradually affect the efforts to improve the quality of Education. This study aims to find the problem of why students are not enthusiastic about their own discipline and then find a solution partispatif with students. The study was conducted at MTs Khaudul Ulum Penajung. The study used an action approach with steps in the form of SWOT analysis, finding problems related to the implementation of student discipline, discussing together the solution, drawing up a solution action plan, organizing to socialize it, then carrying out joint action,and finally reflection evaluating together also for further improvement. The parties involved are the head of the madrasah, deputy head of Student Affairs, the Student Council builders, and student council managers. The management theory used is the theory of plan-do-check-act (PDCA). The results of this action research are: (a)the finding of priority issues stemming from the lack of discipline of students in the Classroom, (b)planned participatory joint action on the manufacture of student rules, (c)The Division of tasks and socialization, (d)the holding of Joint Action for the manufacture of student rules, and (e) reflection to evaluate the implementation of the action. Recommendations/ suggestions: (a)this action activity is developed continuously, and (b)further actions are more directed to the purpose of improving the quality of madrasah. Keywords: action research, quality improvement, student discipline
O estado do conhecimento de pesquisas sobre currículos de Matemática dos Anos Iniciais do Ensino Fundamental na Região Nordeste
Authors: Costa Shirley Conceição Silva da , Curi Edda
Published: December 2022

Este artigo apresenta o estado do conhecimento de pesquisas que analisam os currículos de Matemática para os Anos Iniciais. Para tanto, realizou-se um levantamento de trabalhos no Catálogo de teses e dissertações da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, com tais critérios: pesquisas realizadas no Brasil, em programas de Pós-Graduação em Educação Matemática e em Ensino de Ciências e Matemática, no período de 2015 a 2020, restritas à região Nordeste. A discussão foi fundamentada no método de análise de conteúdo de Bardin, dando destaque às similaridades e diferenças entre as pesquisas. Foi possível observar uma tendência acentuada em análises sobre os desdobramentos dos currículos para o ensino de Matemática, em detrimento da análise do currículo prescrito, propriamente dito. No mais, a maioria dos trabalhos são de nível de mestrado, indicando a necessidade de pesquisas com maior fôlego para analisar os arranjos curriculares em Matemática, para os Anos Iniciais.
Microbiota of female genital tract – functional overview of microbial flora from vagina to uterine tubes and placenta
Authors: Liptáková A , Čurová K , Záhumenský J , Visnyaiová K , Varga I
Published: December 2022

Microorganisms and eukaryotic human cells coexist in synergistic relationships in nearly every niche of the human body. The female genital tract consisting of the vagina, uterus with its cervix and endometrium, uterine tubes and ovaries – harbors its own typical microbiota, which accounts for 9 % of the total bacterial population in females. To this organ system, we also assigned the microbiome of the placenta, which has not been studied much until now. Among the spectrum of microbial species, the female genital tract is mainly dominated by Lactobacillus species, which are considered to be one of the simplest yet most important microbial communities. However, this relationship between macro- and micro-organisms seems to have a number of physiological functions, e.g., the vaginal and cervical microbiota have unique impact on reproductive health. The aim of this review was to provide current view on female genital tract microbiota and its role in reproductive health. We describe in detail the association of vaginal or tubal epithelium with microbiota or the role of microbiota in normal placental function.
Pengaruh Capital Adequacy Ratio (CAR), Financing To Deposit Ratio (FDR), Non Performing Financing (NPF) dan Inflasi Terhadap Profitabilitas (Studi Kasus PT Bank Victoria Syariah Periode September 2013-2018)
Authors: Misuari Margibi , Rahmawati Rafika
Published: December 2022

This research aims to know the influence of Capital Adequacy Ratio (CAR), Financing to Deposit Ratio (FDR), Non Performing Financing (NPF), and Inflation against Profitability Return On Assets (ROA)at PT Bank Victoria Syariah. This study used a sample of Pt Victorian Sharia Bank, based on financial statements within the period for 6 years where the processed data is data per three months averaged starting in 2013 to 2018. The method used applies a quantitative approach to obtain data in the form of numbers so that the objectives in this study are achieved by using multiple linear regression analysis techniques. Results Empirical research shows that there is a simultaneous effect on the variables CAR, FDR, NPF, and inflation on profitability is measured with ROA at PT Bank Victoria Sharia. The results of this research also shows that the CAR . variable partially significant effect
positive on profitability at PT Victoria Sharia Bank, while FDR, NPF and inflation variables do not affect profitability at PT Bank Victoria Syariah. Effect of CAR, FDR, NPF, and Inflation on bank profitability
Victoria sharia is very influential, this is evidenced by the value of sig f
0.014 (p<0.05). Which means that the increasing CAR, FDR, NPF, and inflation will also increase the profitability (ROA) of bank victoria sharia.
Analisis Efisiensi Kinerja Unit Usaha Syariah Di Indonesia Dengan Metode Data Envelopment Analysis Dan Rasio Eagles
Authors: Yasir Tsany Muhammad Fauzan , Putra Purnama , Tirtajaya Mas Deden
Published: December 2022

This research is motivated by global competition that occurs in economic life which requires every institution to determine the appropriate strategy from the point of view of Efficiency and Performance Levels. The purpose of this study is to measure the level of efficiency and performance of the Sharia Business Unit and to see the factors that affect the level of efficiency and performance of the Sharia Business Unit. The research method used in this research is descriptive quantitative using secondary data. Secondary data comes from the documents of Sharia Business Units included in the National Private Commercial Bank. DEA analysis is used to measure the level of efficiency by analyzing internal factors in the form of efficiency targets on total assets, third party funds, labor costs, total financing and revenue sharing, while the EAGLES analysis is used to measure performance which consists of earning ability, asset quality, growth rate, liquidity, equity and strategic management. The results of the analysis using the DEA approach can be seen that the Sharia Business Units in Indonesia have not reached the optimum level of efficiency, this is due to the target on the input variable consisting of total assets, third party funds and labor costs that are still experiencing waste and have not met the efficiency target, while the results of the EAGLES analysis show that the performance of the Sharia Business Unit is in a good performance condition to become an alternative choice for the community.
Analisis Komponen Fraud Diamond Dalam Mendeteksi Financial Statement Fraud Pada Bank Umum Syariah Yang Terdaftar Di Bursa Efek Indonesia Periode 2014-2018
Authors: Fadhilah Farida Nur , Widyananto Arief
Published: December 2022

This study aims to examine the components of fraud in the fraud diamond theory in detecting fraud in financial statements. The research variables consist of pressure (financial stability, external pressure and financial target), opportunity (ineffective monitoring), and capability (turnover). directors) that are hypothesized to influence financial statement fraud. The F-Score is used to determine the financial statement fraud. Sampling was selected using a purposive sampling method, namely Islamic banks that have gone public or are listed on the Indonesia Stock Exchange (IDX) in the period 2014 to 2018. The data analysis method uses multiple regression using SPSS 16 software. Based on the results of hypothesis testing using the t test, it is obtained that financial stability (ACHANGE) and ineffective monitoring (BDOUT) variables have a significant positive effect on financial statement fraud. Meanwhile, external pressure (LEV) has a significant negative effect on financial statement fraud. And financial target (ROA) and capability (DCHANGE) have no significant effect on financial statement fraud. Tests using the F (simultaneous) test found that the variables of financial stability, external pressure, financial target, ineffective monitoring and capability together have an influence on financial statement fraud.
Strategi Pengembangan Bisnis Pada Masa Pandemi Covid-19 Studi Kasus Pada PT. BPRS Artha Madani
Authors: Putri Mega Juliani , Isnandar Fajri Ryan
Published: December 2022

The challenge in Islamic banking during the Covid-19 pandemic was liquidity and the ratio of non-performing financing (NPF). In addition, the uneven liquidity in the banking industry has caused some banks to enjoy excess liquidity and others to lack funds. Due to the pandemic condition, PT BPRS Artha Madani lost liquidity from third party funds within 3 months as many as 98 depositors made large withdrawals. The purpose of this research is to provide alternative suggestions for new strategies in the business development of PT. BPRS Artha Madani during the covid-19 pandemic.The data analysis technique in this study used SWOT analysis through interviews with the management of PT BPRS Artha Madani who has the authority to make decisions for the company and has an understanding of the research topic. Then analyzed through the Quantitative Strategic Planning Matrix or QSPM to determine which strategy will be prioritized in the selection of the recommended alternative strategies through the SWOT matrix.The results show that the highest score (Total Attractiveness Score) or TAS of 19.166 is Creating a personal e-commerce platform belonging to BPRS Artha Madani, an alternative name, namely Artha Madani Market. Because during this pandemic, people prefer to do online transactions at home to minimize the spread of covid-19.
REVIEW ON RECENT ADVANCEMENTS IN BIONICARM
Authors: Mujumale Atharva , Kalke Siddharaj , Mulik Omkar , Narkar Omkar ,   Department of Mechanical Engineering, APSIT, Thane
Published: December 2022

Bionic arm has been a prime example of bending technology to improve the lives of amputees. This paper aims to study bionic arm and its developments through the years. The paper primarily focuses on the ‘mechanical-human spectrum’ and its implications on the feasibility of the arm. This paper also highlights the various actuation systems used in practice which are a key component of the arm. When feedback is provided to any system its performance is enhanced, this is also true in case of the arm and the paper describes all aspects related to it
IMPACT STUDY OF SOLAR BASED LIFT IRRIGATIONIN SOHAGPUR BLOCK (MP)
Authors:   IIFM Bhopal, Ahake Mahesh
Published: December 2022

The Study is conducted to see impact of Solar Lift Irrigation System (SLIS) on farmers livelihood and income. the project takes place in a small region Sohagpur block of Shahdol (MP); in Sohagpur block 46 SLIS has been installed which is impacting 30 villages with 250 families with a total of more than 200 acres of cultivated area. Before this intervention farmers usually used the T.C. Connection pump or diesel pump for irrigation, but it was costly and not feasible after this intervention there was a huge change in their life and farming. Some of the beneficiaries changed their cropping patterns and some of them increased their variety of crops. Before this, they depend on rain-fed paddy production only, but they are producing vegetables, wheat, chana, paddy, arhar, etc. SLIS has been distributed here in small groups so everyone can benefit from it, thus an increase in their income and livelihood can be seen there. Some farmers also started brick manufacturing units on their farms as a side business to increase their livelihood and income. As Solar energy is form of renewable energy so it can be future for human in upcoming days and for farmers it is very helpful now, they do not need to suffer from lack of electricity or they don't need take risk in night for irrigation purpose only because of availability of electricity in Night now they can irrigate their farm in day as per their convenience even in summer time they are now able to do farming with different types of crops.
E-WASTE BUSINESS MODEL, POLICIES & REGULATIONS IN INDIA
Authors: Srividya Prakhya Surya , Yadaganti Raghu ,   PES University
Published: December 2022

This research paper focuses on electronic waste - also commonly referred as e-waste, business models created and the policies and regulations enforced in order to manage this category of waste. This research paper aims to provide a thorough understanding on the concept of e-waste that is dealt with in the country India. This study also provides knowledge on the harmful effects of stagnated e-waste and its impact on the environment while also providing statistical data on the e-waste generated city wise. It concerns how E-waste business models play a critical role in the recycling industry and the numerous policies and rules implemented as an attempt, by the Government, to keep e-waste under control. Additionally this study provides an understanding and brief idea on the numerous career opportunities that e-waste recycling brings along in today's world. This topic helps in comprehending the emerging recycling techniques and e-waste regulatory measures with the objective to avoid harming the environment.
TO ASSESS THE NUTRITIONAL KNOWLEDGE AND EDUCATE THE SIGNIFICANCE OF NUTRITION AMONG OUTPATIENTS UNDERGOING HEMODIALYSIS
Authors: Saliha M. Farhana , Krishnan Dr. Vinitha ,   SIMS Hospital, Vadapalani, Chennai, Tamil Nadu, India
Published: December 2022

Background: Globally, Chronic kidney disease (CKD) is the 16th leading cause of death. Patients with CKD stage III or above are likely to undergo dialysis based on their Glomerular filtration rate (Teresa K. Chen et al 2019). Nutrition education plays an important role in improving nutritional status in patients undergoing hemodialysis (HD). Aim & objective: The aim of the study is to assess the Nutritional knowledge and educate the significance of nutrition among outpatients undergoing hemodialysis. Material & methods: After obtaining approval from the Head of the Nephrology department, the study was carried out in Hemodialysis unit at a Multispecialty hospital in Chennai. The total of 153 (N =153) patients receiving hemodialysis were selected for the study based on non - probability convenient sampling method. A questionnaire was designed to assess the patient’s awareness on dietary restrictions in particular to protein Sodium, potassium and fluids during Hemodialysis (HD). Educative pamphlets were formulated based on KDIGO guidelines 2020 and the same was used to subjects. The feedback about the effectiveness and usefulness of the handout was collected. Results: From the study it is evident that nutrition education/ diet counselling will help the patients adhere to the food restriction. This is also been statistically proven (p value – 0.00) for association of subjects following food restrictions for potassium rich foods post dietitian counselling. The percentage of the effectiveness of the nutrition counselling was 61% in patients undergoing hemodialysis.
ADOPTION OF ICT: A NECESSARY STRATEGY FOR SUSTAINABLE DEVELOPMENT IN THE TWENTY-FIRST CENTURY NIGERIA
Authors: Chinenye Duru Juliet , Divine Okezie Maduabughichi , Mcdonald Nkwocha ,   Abia State University, Uturu, Nigeria
Published: December 2022

The worldwide economic system is increasingly becoming dependent on the ICT system. This article discusses ways in which ICT contributes to several aspects of global sustainability in the areas of Egovernment, E-learning, and E-commerce. The design employed in the study was a descriptive survey. The study was conducted in Aba North local government area of Abia State, Nigeria. Primary data was used for this research work. A sample size of 150 respondents was randomly selected for the study, covering the education sector using the Education Management Board Staff; commerce and industry, using a staff of the ministry; and government/public sector using the Local Government Staff; with each sector having a selected 50 respondents. The instrument used was a 12- item questionnaire on the adoption of ICT as a strategy for sustainable development using E-government, Elearning, and E-commerce as explanatory variables of ICT Adoption. The data collected for the study were analyzed using the appropriate percentage and the responses of the respondents were subjected to a rating scale using their boundary percentages as a basis for their score/rating. The finding revealed that Egovernment enhances the operations of the government and facilitates the effective delivery of government programs’-Learning provides convenient and flexible access to learning; whereas Commerce changed the way goods and services are produced, delivered, sold, and purchased. ICT has led to an ever-growing number of people and businesses connected digitally. Most Nigerians could participate in the International markets from the comfort of their offices and rooms.ICT adoptions have the potential to promote sustainability, productivity, and economic growth through job creation. We, therefore, conclude that ICT Adoption is a veritable tool for sustainable national development in Nigeria. We recommend among others, that Government and other stakeholders should mobilize resources for equipping businesses, education, and governmental sectors with ICT infrastructure and should also embark on Multilevel skill building (capacity improvement).
ACCOUNTING FRAUD IN CORPORATE: CASE STUDY ON SATYAM COMPUTERS LIMITED
Authors:   Amazon Development Centre, Sanjay Upadhya
Published: December 2022

In the modern globalized and liberalized era, the firms are facing stiff competition and are under pressure to show the good financial results through financial reporting. In such an environment, they start using the creative accounting practices, especially in unsuitable situation to boost up the profit or manipulate the assets and liabilities to report to the stakeholders the image that is better than the actual image. Corporate accounting fraud is a major problem that is increasing both in its frequency and severity. Research evidence has shown that growing number of frauds have undermined the integrity of financial reports, contributed to substantial economic losses, and eroded investor’s confidence regarding the usefulness and reliability of financial statements. An attempt is made in this paper to examine in-depth and analyse India's Enron, Satyam Computer's " creative-accounting " scandal. Satyam was brought to its knee due to 'tunnelling' effect. The Satyam scandal highlights the importance of securities laws and Corporate Governance in emerging markets. Their scandal/fraud has put a big question mark on the entire corporate governance system in India. Indeed, Satyam fraud "spurred the government of India to tighten the CG norms to prevent recurrence of similar frauds in future. Thus, major financial reporting frauds need to be studied for “lessons-learned” and “strategies-tofollow” to reduce the incidents of such frauds in the future. Thus this paper is devoted to the case study of Satyam, its creative accounting scandal and the effect of it on the global market.