bluuebunny/crossref_metadata_2025 huggingface dataset:
Validation of the Turkish Version of the Mental Health Literacy Scale
Authors: Günadyın H. Deniz
Published: June 2024

This study aimed to adapt the MHL scale and research the measurement properties of the Mental Health Literacy Scale (MHL). The calibration research used a sample of Turkish participants (n = 633) aged 18 and older, resulting in a 19-item scale with three factors. The second sample of Turkish participants (n = 810), the validation research, convergent and divergent validity, and correlational and test-retest reliability was performed. Using the AMOS 26 and SPSS 25 for MAC, respectively, confirmatory factorial analysis and exploratory factor analysis were carried out. The adaption of the MHL to Turkish revealed a three-category structure: knowledge orientation, beliefs orientation, and resource orientation. The confirmatory factorial analysis disclosed that the model with three-factor was satisfactory fit values. The Mental Health Literacy Scale seems to be a vigorous and reliable tool for assessing the degree of knowledge orientation, belief orientation, and resource orientation to MHL in Turkish culture.
Çorum İli İmalat Sektörü Üç Yıldız Analizi
Authors: Duran Emre
Published: June 2024

Küresel pazarda yaşanılan gelişmeler, yerel düzeyde rekabet gücü yüksek olan firmaların rekabet avantajı kazanmasını sağlamıştır. Bu durum endüstriyel yığılmalara olan ilgiyi artırmıştır. Yerel ekonomilerin küresel ekonomideki önemine dikkat çeken kümelenme yaklaşımı, birçok ülke tarafından kalkınma stratejisi olarak uygulanmaktadır. Tarihi ticaret yolları üzerinde bulunan Çorum ilinde Cumhuriyetin ilan edildiği yıllarda üretim faaliyetleri evlerde veya küçük işletmeler şeklinde atölyelerde yapılmaktaydı. 1972’de Çorum ilinin Kalkınmada Öncelikli Yöreler arasına girmesiyle ilde sanayileşme faaliyetleri hızlanmıştır. 1980’de ithal ikameci sanayileşme politikasından dışa açık büyüme modeline geçmesiyle Türkiye’de desantralizasyon alanlarının gelişimi teşvik edilmiştir. Çorum sağlanan teşviklerle 1980 sonrası hızlı bir şekilde sanayileşerek Anadolu Kaplanları olarak anılan iller arasında yer almıştır. Çalışma Çorum ilinde Ekonomik Faaliyet İstatistiki Sınıflaması (NACE kodu) kapsamında imalat sınıfında yer alan alt sektörlerin yoğunlaşma düzeyini tespit etmeyi amaçlamaktadır. Bu amaç doğrultusunda çalışmada TOBB Sanayi Veritabanı içerisinde yer alan illere göre üretici dağılımı verilerinden yararlanılmıştır. Elde edilen verilerle üç yıldız analiz yapılmıştır. Üç yıldız analizine göre Çorum ilinde NACE kodu sınıflamasında 4 kod bazda faaliyette bulunan 129 sektörden 13’ü olgun küme olarak sınıflandırılırken, 19’u potansiyel küme, 18’i ise aday küme olarak sınıflandırılmıştır.
Soğuk İklim Kentlerinde İklim Değişikliğine Uyumlu Kentsel Tasarım İlkeleri
Authors: Samancı Özlem Nur , Toy Süleyman
Published: June 2024

Kentler, yeryüzünün %2’sini kaplamasına rağmen iklim değişikliğine etkisi ve iklim değişikliği kaynaklı tehlike ve risklerden etkilenebilirliği yüksek düzeyde olan alanlardır. İklim değişikliğinin etkileri dünya üzerinde coğrafi alanlara ve yaşam alanlarının özelliklerine göre değişmektedir. Bu bakımdan, soğuk iklim kentleri olarak sınıflandırılan kentlerde de iklim değişikliğinin etkileri açık şekilde görülmeye başlamıştır. Kentler iklim değişikliğini etkileyen ve iklim değişikliğinden etkilenen alanlar olması nedeniyle hem iklim değişikliğine etki eden faktörleri azaltmak hem de ortaya çıkan etkilere uyum sağlamak için yapılacak planlama, tasarım ve uygulama çalışmalarına temel olacak bilimsel çalışmalar yapılması gerekmektedir. Bu çalışmanın amacı, soğuk iklim kentlerinde belirginleşen iklim değişikliği kaynaklı tehlike ve riskler hakkında literatür kaynaklı bilgiler vermek ve kentlerde iklim değişikliğinin etkilerini azaltmak ve uyum sağlamak için kentsel tasarım yaklaşımlarına dair ilkeleri ortaya koymaktır. Çalışma sonucunda, soğuk iklim kentlerinde ortaya çıkan iklim tehlike ve risklerine karşı mekânsal tasarım yoluyla azaltım ve uyum sağlanabileceği görülmüştür. Soğuk iklim kentlerinde iklim değişikliğinin etkilerine uyumlu kentsel planlama ve tasarımda kentlerde öne çıkan faktörlerin; güneşlenme şiddeti ve süresinden etkin yararlanma, rüzgâr etkisinin hava kirliliği ve kentsel ısı adasının etkisini kırmak için kullanılması, kar ve diğer yağış tiplerinin etkisinin yönetimi, kent ve yapıların tasarımının uyumlu hale getirilmesi, kentsel yüzey malzemelerinin seçimi, bitki örtüsünün sürdürülebilirliği ve kentsel ulaşım sistemlerinin yeniden kurgulanması gibi çok çeşitli başlıklarda sınıflandığı görülmektedir.
Средние города в Бразилии: особенности современного развития и место в системе расселения
Authors: Арцыбашева Ксения Владимировна
Published: June 2024

В статье рассматривается феномен средних городов Ȧразилии, которые в последние десятилетия играют все более заметную роль в социально-экономическом развитии страны. Для выделения городов в категорию средних использован критерий численности городского населения в муниципалитете (от 100 тыс. до 500 тыс. человек), однако для оценки функции таких городов в системе расселения также необходимо учитывать их географическое положение и социально-экономические характеристики. Целью статьи стало выявление значения городов среднего размера в Бразилии и их характерных черт. Пик роста средних городов пришелся на 1970K1990-е годы и был связан с интенсивным развитием урбанизации и индустриализации. Темпы прироста населения средних городов постепенно замедляются из-за демографических изменений и смены направлений и интенсивности миграции. Анализ муниципальной структуры занятости на основе расчетов индекса Xерфиндаля-Хиршмана и коэффициента локализации показал неоднородность городов этого типа в зависимости от расположения относительно центров агломераций. В результате исследования было выделено 9 типов средних городов Бразилии, самыми распространенными из которых стали растущие пригороды крупных агломераций, а также средние города с небольшим миграционным оттоком, расположенные во внутренних частях штатов в староосвоенной части страны.
Также в статье приводятся характеристики средних городов Бразилии в зависимости от их принадлежности к макрорегионам: Северо-Восточному, Юго-Восточному, Южному, Северному и Центрально-Западному. Средние города — важные элементы в иерархии городских центров Бразилии, которые способствуют деконцентрации населения на территориях с высокой плотностью населения и в районах влияния крупнейших городских агломераций, а также выступают в роли опорных пунктов в районах нового освоения.
Platelet purification and coating of plates for adhesion assays v1
Authors: King Samantha
Published: June 2024

This is the protocol we use to prepare fixed platelets from human blood and coat wells ready for adhesion assays.
The Relationship Between Gifted Students' Self-Efficacy Perceptions of Computational Thinking Skills and Information Technologies Self-Efficacy Perceptions
Authors: Olpak Tarık , Karamete Aysen
Published: June 2024

Today, due to the effect of developing technology and compulsory reasons such as epidemics, education and training activities can be done through distance education. In order for these activities, which are mostly carried out through technological tools such as computers, tablets and the internet, to be effective, they must be able to address the needs and changing characteristics of the students. In this context, the aim of the research is to examine whether there is a relationship between the self-efficacy perceptions of gifted students regarding computational thinking skills and their information technology self-efficacy perceptions. The sample consists of 130 secondary school students studying via distance education in Science and Art Centers in Balıkesir in the 2020-2021 academic year. As a result of the analyzes, it was observed that gifted students' computational thinking and information technology self-efficacy perceptions were above the average and there was a high positive correlation between them.
Matrix Metallopeptidase 3 Coding SNPS Suppress Cell Invasion in MCF7 Breast Cancer Cells
Authors: Ahmad Suhaimi Shafinah , Soon Choy Chan , Chong Pei Pei , Saad Norazalina , Chau De Ming , Rosli Rozita
Published: June 2024

Matrix metallopeptidase 3 (MMP3) is among the key players in breast cancer metastasis that contributes to the highest cancer-related deaths in females globally. Previously, in silico analyses had shown that several coding single nucleotide polymorphisms (SNPs) of MMP3 were predicted to alter the secondary structures of MMP3 and subsequently reduce its mRNA stability. To validate the mentioned hypotheses, this study aimed to determine the effects of six coding SNPs of MMP3 on its mRNA stability, protein expression level as well as cell invasiveness in vitro. In this study, breast adenocarcinoma MCF7 cells were transfected with MMP3 wild type (MMP3-WT) and a variant containing SNPs (MMP3-Var). Following transfection, protein expression level, mRNA stability and enzyme activity of MMP3-WT and MMP3-Var were evaluated. Finally, the effect of MMP3 coding SNPs on cell invasiveness in breast cancer was determined. In this study, the mRNA stability, protein expression level and enzymatic activity of MMP3-Var were significantly reduced. Moreover, the presence of MMP3 coding SNPs led to attenuated invasiveness of transfected MCF7 cells. In conclusion, these findings may contribute to the current understanding of these coding SNPs with metastasis in breast cancer.
Metroxylon sagu Rottb. Fruit Flour as Potential Prebiotics for Selected Probiotics and Phytochemical Profiling of its Methanolic Extract by LC-MS/MS
Authors: Fadhilla Reza , Yuliana Nancy Dewi , Kusnandar Feri , Kusumaningrum Harsi Dewantari
Published: June 2024

The plant of Metroxylon sago Rottb. which is found abundantly in Indonesia, Malaysia, Philippines, and Papua New Guinea, is famous as carbohydrate producing plants. The sago fruit has not been yet extensively used, although they are rich in oligosaccharides which is potential as prebiotic. Sago fruit flour was studied as growth substrate for five selected probiotics and phytochemical profile of its methanol extracts were determined. All bacteria grew well up to 24 h on the growth medium containing sago fruit flour as carbohydrate substitute. However, Lacticaseibacillus rhamnosus FNCC 0099 and Lactobacillus acidophilus FNCC 0051 showed viability stability up to 72 h, while the others were slightly decreased. The sago fruit flour contained 20.4 mg/g total sugars, 14.8 mg QE/g flavonoids, and 36.7 mg GAE/g phenolics. After extraction of the fruit flour with 80% methanol using an ultrasonicator at 55 °C at 40 kHz for 40 min, the extract was analysed for its phytochemical profiles using untargeted LC-MS/MS screening with negative ionization mode. Seven compounds categorised in three distinct groups i.e., sugar alcohol, plant glycosides and fatty acids, have been identified as having possible prebiotic activity. These include ((1xi)-1,5-anhydro-2,3,6-tris-O-(carboxymethyl)-1-methyl-4-O-methyl-D-glucitol), quercitrin, (15Z)-9,12,13-trihydroxy-15-octadecenoic acid, corchorifatty acid F, 3,5-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-7-yl-hexopyranoside, gynocardin, and (4-methylumbelliferone)-b-D-glucopyranoside. As the sago fruit flour has been proved as potential prebiotic in this study, its extensive prebiotics activity, prebiotic index, and stability under digestive condition will be subjected for further study.
Greece’s 2015 Eurozone Bailout “Renegotiation”: Beware of Greeks Bearing “Unpolitics”?
Authors: Zartaloudis Sotirios
Published: June 2024

In January 2015, Greece witnessed a political earthquake with the election of the populist anti-austerity/EU bailout coalition of the left-wing party SYRIZA and the far-right party ANEL. It is argued that during January–July 2015, the SYRIZA–ANEL coalition engaged in a protracted process of renegotiation of Greece’s bailout terms that were agreed between previous Greek governments and the so-called Troika (European Commission, European Central Bank, and International Monetary Fund) adopting a behaviour ruled by “unpolitics.” First, the SYRIZA–ANEL government immediately rejected formal and informal rules of EU decision-making. Second, the SYRIZA–ANEL government rejected traditional means of compromise, such as package deals and side payments. Third, when Greece’s creditors presented their last-minute bailout offer in June 2015 to avoid Greece leaving the eurozone (Grexit), the SYRIZA–ANEL government rejected the suggested solution and tried to exploit the ensuing deadlock by calling a rashly organised referendum asking Greeks to vote against the suggested deal. This period of “unpolitics” ended almost immediately after the referendum when, in a sudden and unexpected volte-face, Tsipras interpreted the referendum result as a call for compromise with the Troika and accepted the previously intolerable bailout deal.
Alcoholic cardiomyopathy: aspects of pathogenesis and clinic
Authors: Klemenov A. V.
Published: June 2024

Alcoholic cardiomyopathy is the most common form of myocardial damage caused by ethanol. Ethanol and its main active metabolite acetaldehyde have a direct toxic effect on the myocardium. The mechanisms of the cardiotoxic effect of ethanol are diverse and include membranotropic action, damage to cellular organelles, activation of lipid peroxidation, and a number of others. Dissolving in the lipids of biological membranes, ethanol changes their physico-chemical properties, disrupts the activity of membrane receptors, eventually disconnecting the connection of excitation with the contraction of cardiomyocytes. Particular importance in the pathogenesis of alcoholic cardiomyopathy is attached to the ability of ethanol to cause structural and functional changes in mitochondria, which is directly related to the violation of oxidative processes and energy supply of the myocardium as a whole. Under the influence of alcohol, free-radical lipid oxidation products content increases and antioxidants activity decreases, which indicates oxidative stress development. The deterioration of myocardial contractility due to chronic alcohol intoxication triggers a cascade of compensatory mechanisms in the form of cardiomyocyte hypertrophy and progressive fibrosis, while adaptive reactions become a factor in further pathological changes. Ethanol causes myocardial damage in a dose-dependent manner.

The probability of alcoholic cardiomyopathy occurrence is a derivative of the total accumulated dose of alcohol and individual predisposition. Alcoholic cardiomyopathy is considered as a variant of secondary dilated cardiomyopathy with all its clinical manifestations and consequences: dilation of the heart chambers, low left ventricular ejection fraction, progressive circulatory insufficiency, and cardiac arrhythmias. A relatively favorable prognosis in alcoholic cardiomyopathy is provided due to partial reversibility of myocardial damage under the condition of abstinence from alcohol consumption. Specific drugs for the treatment of alcoholic cardiomyopathy have not been developed. New treatment strategies include the use of myocardial growth and regulation factors synthesized by cardiomyocytes, as well as the stimulation of heart muscle regeneration and repair processes.
Hemostasis parameters in patients with arterial hypertension, multifocal atherosclerosis and risk factors
Authors: Vedenskaya S. S. , Smolenskaya O. G. , Grachev V. G. , Klyachina E. S. , Kupriyanova I. N. , Vedensky V. A.
Published: June 2024

Aim. To determine the features of hemostasis system disorders and the possibility of their correction in patients with arterial hypertension (AH) and multifocal atherosclerotic lesions (MFA) with risk factors indicated.

Materials and methods. The study included 135 patients (mean age 53.7 ± 7.76 years), including 80 patients with controlled AH stage and II (group 1) and 55 patients with controlled AH stage III who had ischemic stroke (group 2). Among all patients studied, 33 patients (24.4 %) were smokers. All 135 patients received comparable antihypertensive, antiplatelettherapy (acetylsalicylic acid at a dose of 100 mg/day), had MFA and target lipid spectrum values.

Results. Procoagulant shifts are noted already in patients with AH stage I and II, especially in the presence of smoking. Such indices of global thrombodynamics test as initial clot growth rate, average clot growth rate, clot size significantly exceed the reference values and indicate high prothrombogenic potential in patient with AH and MFA. Prescription of dual antiplatelet therapy allows normalization of identified disorders. Presence of risk factors (smoking) aggravates existing hemostasis disorders in patients with AH and MFA.

Conclusion. Smoking cessation, optimization of risk factors and complex antihypertensive, hypolipidemic and antithrombotic therapy are the basis of treatment of patients with AH and MFA and can be considered as priority measures to reduce morbidity and mortality in this patient population.
Implicit Promises in Russian Political Discourse
Authors: Parfenova L.V.
Published: June 2024

The relevance of the research is due to the significant practical and theoretical interest in implicitness, in particular, to the functioning of implicit promises in Russian political discourse. The article presents the results of an experiment conducted by the author in 2023–2024 in order to identify the linguistic characteristics of an implicit political promise in Russian, describe and evaluate the impact of polymodality on the perception of a promissive textotype by the audience. To achieve this goal, methods of continuous computer sampling, questionnaires and critical discourse analysis were used, which allowed to identify lexical markers of the implementation of the intention of a promise in an implicit form in Russian political discourse, as well as to describe the influence of polymodality on the perlocation of a promise. The study sample included mini-texts with a leading promissive intention, selected for the period from 1998 to 2024.
New Coumarin Ring-Containing Ester Molecule: Facile Synthesis, Characterization, Computational Studies and SwissADME Prediction
Authors: Saraç Kamuran
Published: June 2024

The aim of the study was to synthesize 4-Coumarinyl-2-methylbenzoate, elucidate the reaction mechanism, perform quantum chemical calculations, and examine the swiss adme properties of the compound. 4-Coumarinyl-2-methylbenzoate compound was synthesized by nucleophilic substitution reaction. The compound 4-coumarinyl 2-methyl benzoate has been characterized both experimentally and theoretically using quantum chemical calculations and spectral techniques. Nuclear magnetic resonances and infrared spectroscopic values of 1H and 13C in the ground state of the compound were calculated both experimentally and theoretically (density functional theory method was used when making theoretical calculations). It was observed that the calculated infrared and nuclear magnetic resonance values were compatible with the experimental values. The energy difference between the HOMO-LUMO of the 4-Coumarinyl-2-methylbenzoate compound was calculated and it was found that this difference was 1.409 Ev.
Finally, swiss adme properties of 4-Coumarinyl-2-methylbenzoate compound such as Molecular Mass (Size), Flexibility (FLEX), Polarity, Saturation (Insatu), Lipophilia, Water Solubility were examined.
Conventional structural magnetic resonance imaging in differentiating chronic disorders of consciousness
Authors: Sergeeva Anastasia N. , Morozova Sofya N. , Sergeev Dmitrii V. , Kremneva Elena I. , Zimin Alexey A. , Legostaeva Lyudmila A. , Iazeva Elizaveta G. , Krotenkova Marina V. , Ryabinkina Yulia V. , Suponeva Natalya A. , Piradov Michael A.
Published: June 2024

BACKGROUND: Differential diagnosis of chronic disorders of consciousness remains one of the most difficult problems even for experienced clinicians.
AIM: To evaluate the inter-expert consistency and capacity of the researcher-developed structural scale based on magnetic resonance imaging to differentiate chronic disorders of consciousness, named, DOC-MRIDS, on a larger sample of patients.
MATERIALS AND METHODS: Sixty patients with a clinically stable status diagnosed with consciousness disorders (vegetative state, n=32; minimally conscious state, n=28) were enrolled. The revised coma recovery scale (CRS-R) was included in the clinical assessment. All patients underwent structural magnetic resonance imaging with 3.0-T Siemens scanners including T2 and T1 sequences. Structural changes were assessed using the DOC-MRIDS scale and included the following features: diffuse cortical atrophy, ventricular enlargement, gyri dilatation, leukoaraiosis, brainstem and/or thalamic degeneration, corpus callosum degeneration, and focal corpus callosum lesions. A total score was calculated. Magnetic resonance imaging data were analyzed by three neuroradiologists, and inter-observer agreement (Krippendorf’s alpha) was assessed.
RESULTS: A high inter-examiner agreement of the DOC-MRIDS scale score was found, with α=0.806 (95% confidence interval 0.757–0.849). The vegetative state group had a higher DOC-MRIDS score than the minimally conscious state group (p 0.005). A negative correlation was obtained between CRS-R and DOC-MRIDS scale scores (ρ=–0.457, p 0.0001), individual clinical scale domains, and magnetic resonance imaging features.
CONCLUSION: When assessing structural changes in patients with chronic consciousness disorders, the use of the DOC-MRIDS scale helps differentiate the type of such disorders with sufficient specificity, sensitivity, and inter-rater agreement. This scale can be used in clinical practice as an additional differential diagnostic tool.
Difficulties in diagnosing rabies using the example of a clinical case in the Omsk region
Authors: Puzyreva Larisa V. , Poleshchuk Elena M. , Bardina Nina V. , Vasilyeva Olga V. , Sidorov Gennady N. , Sergunova Marina A. , Tolokh Inna M. , Semenova Tatyana G. , Savkina Ekaterina S. , Tagakova Daria N. , Bukareva Yulia V. , Sheveleva Irina A. , Petrovskaya Olga V. , Pnevsky Yuri A. , Tkacheva Marina G.
Published: June 2024

Rabies is the deadliest zoonotic disease caused by the rabies virus, a member of the genus Lyssavirus. The disease occurs after a bite from a wild or domestic animal.
The paper presents a clinical case of rabies with early diagnostic difficulties, particularlyclinical, epidemiological, and laboratory diagnostic features, in a patient suffering from alcoholism. The victim sought medical help 20 days after the dog bite. On day 29, a hydrophobia clinic was observed. The patient exhibited signs of visual and auditory hallucinations, aggressiveness, and disorientation in place and time, which resembled the development of alcoholic psychosis. Saliva samples were collected on day 3 of the disease, and its polymerase chain reaction test was negative for rabies virus. On day 29, the patient died. The diagnosis of rabies was confirmed antemortem and posthumously. The virus was detected in the saliva on day 9 of the disease and posthumously in the cerebral cortex, medulla oblongata, cerebellum, and salivary glands. Histologically, Babesh–Negri bodies were found in the brain tissue. Necessary preventive measures were implemented.
The unfavorable outcome in the described case of rabies emphasizes the lack of awareness of the population (especially rural) about the risk of contracting rabies infection through contact with animals and the importance of timely post-exposure prophylaxis. Timely anti-rabies care remains the only effective means of preventing related deaths.
Collaborating for success: empowering medical professionals through interprofessional education
Authors: Shrivastava Saurabh , Savirani Rifda
Published: June 2024

Interprofessional education (IPE) refers to training activities to foster collaborative learning among students from different healthcare professions with the intention to augment the quality of patient care activities. Interprofessional education has been linked with significant impact and accounts for significant benefits that it adds to patient care, healthcare professionals, and even the healthcare delivery system as a whole. Medical institutions that are planning to introduce interprofessional education within their settings must adopt a structured framework to ensure effective delivery of IPE that can train students to develop the required set of skills and competencies that are essential for patient-centered practice. A wide range of challenges has been identified that can impact the implementation of effective IPE in a medical college. There is an immense need to overcome these challenges to facilitate IPE by creating an enabling environment that supports interprofessional collaboration. In conclusion, interprofessional education has a special place in the medical education delivery, as it has the potential to encourage collaborative practice, patient-centered care, and effective teamwork among different types of healthcare professionals. Thus, it is the need of the hour that each medical institution should explore opportunities for interdisciplinary learning and adequately prepare their students for the complexities of modern healthcare.
Stroke-related atrophic muscle group strengthening with an isokinetic dynamometer
Authors: Günaştı Özgür , Özdemir Çiğdem , Özgünen Kerem , Kerimov Kerim , Coşkun Benlidayı İlke , Kurdak Sanlı Sadi
Published: June 2024

Hemiplegia is characterized by neuromuscular dysfunction that disrupts the patient’s quality of life and daily activities. Gait disorders can be observed in post-stroke hemiplegic patients. In addition to neurological and physical therapy approaches, individually prepared isokinetic exercises help the patient return to normal life. A 38-year-old patient with right-sided post-stroke hemiplegia was enrolled in a 4-week lower extremity exercise program specific to his current condition using an isokinetic dynamometer.Due to the 4-week lower extremity strengthening program, there was an increase in quadriceps and hamstring muscle strength and body muscle mass. According to the physical activity questionnaire, the patient’s daily activity increased, and it was determined that he could walk 15.4% longer in the 6-minute walk test. Hemiplegic patients can be supported to return to their daily lives and become more active with personalized isokinetic dynamometer muscle-strengthening programs. In addition, it may be possible to prevent or delay the occurrence of many cardiovascular, metabolic, and related diseases that may occur due to sarcopenia and sedentary life.
Clinical, histopathological features and malignancy frequency of patients with idiopathic inflammatory myopathy
Authors: Altunel Kılınç Elif , Tüzün Zeynep , Kırmızıer Gizem , Varkal Gizem , Türk İpek , Arslan Didem , Özer Hüseyin Turgut Elbek , Özbek Süleyman
Published: June 2024

Purpose: Idiopathic inflammatory myopathy (IIM) group diseases are strongly linked to cancer. This study aims to describe the clinical and histopathological features of IIM patients diagnosed in our clinic, evaluate the frequency and subtypes of accompanying malignancies, and examine the relationship between pathological staining patterns and IIM subgroups.
Materials and Methods: This retrospective study included 74 patients with IIM diagnosed between 2010 and 2023 who had a muscle biopsy at the time of diagnosis. Age, gender, imaging, electromyography, and muscle biopsy results were obtained using the hospital's electronic system.
Results: Of the 74 patients with IIM, 45 are polymyositis (PM), 27 are dermatomyositis (DM) and two are inclusion body myositis (IBM). Malignancy developed in 12 (16%) of 74 IIMs, two (16.6%) of whom had malignancy before the diagnosis of IIM (one breast cancer, one thyroid papillary cancer). Malignancy was diagnosed in five patients (41.6%) in the PM group (the most common breast cancer), five patients (41.6%) in the DM group (the most common endometrial cancer, and two patients (16.8%) in the IBM group. It was found that positive staining with membrane attack complex was higher in the DM group compared to the PM group.
Conclusion: Cancer screening should be performed at regular intervals in IIM patients. Breast and endometrial cancer screening should be prioritized in female patients, as well as lung cancer screening in male patients. Large cohort studies are needed to explain the relationship between pathological staining patterns and IIM subtypes.
Xornadas 8M. Mulleres e independencia económica: traballo e sociedade en perspectiva histórica
Authors: Pico Calvo Candela , Carballo Rodríguez Miriam , Vázquez García Nerea
Published: June 2024

Co gallo da conmemoración do 8M, a Oficina para a Igualdade de Xénero (OIX) da Facultade de Economía e Empresa (FEE) da Universidade da Coruña (UDC) organizou no ano 2024 unhas xornadas centradas nas Mulleres e independencia económica. Estas xornadas levaban por subtítulo Traballo e sociedade en perspectiva histórica, xa que a participación laboral e a conquista dos espazos sociais por parte das mulleres están ligados. Estes aspectos abordáronse dende a perspectiva histórica para tratar de amosar que foron avances lentos e nos que, en moitas ocasións, houbo retrocesos. Dende as institucións é fundamental continuar traballando na concienciación da participación das mulleres no mercado laboral como factor para o crecemento económico e para o benestar, tanto a nivel xeral, como a título particular. Non só iso, senón que cómpre rachar coas ideas preconcibidas e os estereotipos sobre a devandita participación laboral emanados dende o cinema, as redes sociais e outros medios de entretemento. Especialmente aqueles que sitúan á muller como persoa inactiva no eido laboral, demostrando que traballaron de xeito activo, malia que, maioritariamente, no mercado laboral informal. Deste xeito, non só se eliminan representacións das mulleres erróneas, senón que ao mesmo tempo se aportan referentes para as
Grupos etarios de emprendedores agropecuarios en el Paraguay. Año 2023
Authors: Peña-Cardozo Angel Ramón , Ovelar-Benítez Hugo Miguel , Oporto-Giménez Adán Ariel , Torales-Solís Genaro Marcial , Fischli-Lugo Elsa María
Published: June 2024

Uno de los componentes con mayor efecto en el desarrollo de un emprendimiento es el que respecta a las características del emprendedor. El trabajo de investigación tuvo como objetivo sondear el grupo etario de los emprendedores agropecuarios en el Paraguay. Primeramente, se realizó una revisión bibliográfica documental tomando datos oficiales con respecto a la composición etaria del país. En la etapa de campo, se ha tenido un enfoque cuantitativo, con un alcance exploratorio, aplicando el instrumento de levantamiento de datos a un total de 51 propietarios de emprendimientos agropecuarios. El diseño del mismo es no experimental cuantitativa. De las fincas estudiadas el 96% se encuentra dentro de las dimensiones establecidas para ser consideradas en el rango de la Agricultura Familiar Campesina. Todos los emprendimientos cuentan con menos de 10 personas involucradas. En un 96% dirigen un emprendimiento de tipo familiar. La formación académica con mayor porcentaje entre estos es la primaria y secundaria. El 35% de los encuestados pertenece a la Generación X, 26% Millennial, 27% Baby Boomers y 12% a la Generación Z. Si bien la generación Millennial es la Generación predominante a nivel laboral en la actualidad, los resultados prueban que son aun las Generaciones de más edad las que prevalecen en las fincas agropecuarias del país. La Generación X es la de mayor participación en el caso de la muestra ocupando poco más de la tercera parte. Se podría esperar que esta sea la generación preeminente en cuanto a la dirección de los emprendimientos agropecuarias en la futura década.
Peritonitis generalizada de origen apendicular con hallazgo intraoperatorio de situs inversus abdominalis
Authors: González-Ayala Daisy Analía
Published: June 2024

El situs inversus es una enfermedad congénita muy rara que afecta a una de cada 10 000 personas. La revelación desitus inversuspor un síndrome peritoneal es un evento extremadamente raro. Los pacientes con situs inversus tienen una incidencia de 0,016-0,024 % de sufrir apendicitis aguda y generalmente se presentan con alguna complicación. Se presenta el caso de una paciente con peritonitis generalizada de origen apendicular con hallazgo intraoperatorio casual de situs inversus abdominalis.
TRANSIENT SIMULATION OF WIND ENERGY PRODUCTION FOR ELECTRIC MARKET STABILITY
Authors: Ozcan Huseyin Gunhan
Published: June 2024

TToday, energy sustainability, which is one of the most significant concerns in the energy industry, is of utmost importance. In this context, investments and interest in renewable energy sources are growing. As a nation with vast wind energy potential, Türkiye is at the forefront of expanding investments in this sector. This study highlights the significance of wind power plants in electricity market and the relevance of wind energy forecasts, as well as the significance of ensuring the imbalance in energy supply and enhancing electricity market stability. Parallel to this, the transient system simulation (TRNSYS) model was used to determine annual energy generation of a wind power plant in Izmir with a capacity of 18 MW, and the obtained results were compared with the real-time generation data from EPİAŞ transparency platform. The model had two approaches, one based on standard data from the second generation of a typical meteorological year (Plan (1)), and the other on actual field data collected in the plant (Plan (2)).

The numerical findings indicate that the annual energy generation values for Plan (1) and Plan (2) are 24,018.1 MWh and 61,699.1 MWh, respectively. Additionally, the real-time production yields a total of 60,176.2 MWh. In a meantime, Plan (1) generated a positive imbalance value of 45,726.7 MWh, whereas Plan (2) has 6,651.3 MWh over the course of one year. In contrast, the annual sum of negative imbalance values was determined to be 9,475.9 MWh for Plan (1) and 8,368.6 MWh for Plan (2). The analysis yielded annual figures of 2,379,110.4 TL and 351,318.3 TL for positive and negative imbalance penalties, respectively, for Plan (1). For Plan (2), the corresponding amounts were 310,875.9 TL and 337,186.4 TL. Consequently, the total penalty payments for Plan (1) amounted to 2,730,428.8 TL, while for Plan (2) it reached 648,062.3 TL.
ON THE CONTROL AND SIMULATION OF THE THERMAL CONDUCTIVITY IN A HEAT EQUATION
Authors: Güngör Hakkı
Published: June 2024

This study operates the Gradient Method to control the leading coefficient function of a heat equation and presents a Maplet Application which facilitates the computation of control function. The control is heat conductivity function and this function is controlled by aiming the desired value approximation of final heat. After mentioning the existence and uniqueness of the control, the application is submitted by MAPLE mathematical software program and the results are tested on a problem.
NAS ONDAS DO TRABALHO
Authors: Andrade Santos Braz Isac , De Oliveira Camilo Juliana Aparecida
Published: June 2024

Este estudo teve como objetivo investigar as práticas laborais das mulheres trabalhadoras ambulantes no litoral do subúrbio de Salvador, utilizando uma abordagem construcionista ancorada na teoria atriz-rede. A metodologia adotada incluiu observações no cotidiano de trabalho dessas mulheres, nesse sentido, foi feito o uso do diário de campo para o registro de informações produzidas no campo-tema. As informações produzidas envolveram as condições precárias de trabalho, jornadas exaustivas e desigualdades sociais presentes nesse contexto. Além disso, a presença de crianças, adolescentes e idosos nas atividades laborais foi observada, destacando a necessidade de medidas para proteger seus direitos e bem-estar. Os desafios enfrentados durante o estudo incluíram a recusa de algumas participantes em compartilhar suas experiências e a complexidade das interações no campo de pesquisa. Precisa-se desenvolver e implementar políticas e ações que melhorem as condições de trabalho e que promovam a igualdade de gênero no setor informal
Consumers satisfaction with pharmaceutical services in community pharmacies in Benghazi-Libya
Authors: Sharif Suleiman I. , Hitham Shiem , Mohammed Shahed , Tewfik Noran , Inshasi Mahmoud , Elshwehdi Noura
Published: June 2024

Background: The pharmacist, as a front-line provider, is always in contact with patients who come to the pharmacy for various reasons. This study aimed to determine patients’ satisfaction with pharmaceutical services provided by community pharmacists.
Methods: An anonymous, pre-piloted questionnaire-based study was conducted in Benghazi, Libya. Data were analyzed using SPSS, and results were expressed as frequency and percentage of respondents.
Results: A total of 281 completed questionnaires were received back. The majority (196, 69%) of respondents were female. The respondents were of different age groups, but most of them were between 17 and 24 (65.1%) years old. Over 50% of the participants were students (159, 56.6%). The majority of participants find the pharmacist helpful (96%), and 77% of the participants have categorized the pharmacist as a salesman. Most of the participants ask the pharmacist about how to use a medical device, the dose of medication, the frequency of use, the duration of treatment, and the side effects of the medication. Patients (113, 4.2%) do not ask the pharmacist because the physician provided information.
Conclusions: The results of the present study showed a moderate level of patient satisfaction with the help provided by the community pharmacist. However, the pharmacist needs to fully practice his or her role to the advantage of the patients, and the latter needs to be aware of what to expect and demand from the community pharmacist.
Steroidal and gonadotropin hormone profile studies of a classical ayurvedic preparation of “Saraguna Balijarita Makardhwaja” after chronic administration to male Sprague-Dawley rats
Authors: Kishoara Farhana , Munna M. Jakaria Masud , Mousumi T. S. Farah , Neela Nazmun Nahar , Choudhuri M. S. K. , Sikder M. Mamun
Published: June 2024

Background: Saraguna Balijarita Makardhwaja (SGM) is an Ayurvedic preparation used as a traditional antipyretic in the rural population. This research work was designed to get an overview of steroidal and gonadotropin hormone profiles after chronic administration of this drug.
Methods: The acute pharmacological test of SGM recorded no death or any signs of effectivity even at the highest dose of 4000 mg/kg body weight. For chronic pharmacological evaluation, sixteen healthy Sprague-Dawley male rats were randomly divided into two groups, one group was a control group and the other was an experimental group. The experimental group was assigned to receive the drug at a dose of 400 mg/kg of body weight orally. After 28 days of treatment, blood samples were collected for biochemical tests.
Results: The research showed the following effects on the steroidal and gonadotropin hormone profile. In this study, serum circulating level of dehydroepiandrosterone sulfate (DHEA-S), testosterone level, progesterone, 17-beta-estradiol (E2), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) were measured to determine safety profile study of SGM after chronic administration. There were no significant differences in any parameters which is suggesting that SGM has no effect of the steroidal and hormone profile.
Conclusions: According to studies, SGM has no harmful effect on the steroid and hormone profiles after chronic treatment. Further studies are needed to establish the safety aspects of SGM.
Cost analysis study of price variation among the various brands of proton pump inhibitors available in Benghazi-Libya
Authors: Mohamad Khalid A. , Alhallouji Osama S. , Alabbar Izzaldien H. , Alfitori Abdallah M. , Sharif Suleiman I.
Published: June 2024

Background: A large proportion of patients in developing countries have to pay out of pocket for their medications. The prices of different brands of the same medications vary considerably and may vary from one community pharmacy to another. This study was undertaken to evaluate the variation in costs of proton pump inhibitors (PPI) and histamine H2-receptor antagonists available in Libya.
Methods: Prices of various brands of PPI and various formulations were collected from four community pharmacies in the city of Benghazi. Both cost ratio and percentage variation were calculated and compared for various brands of the same strength and number of tablets, capsules, injections, or syrups.
Results: The highest cost ratio and percentage price variation were found with omeprazole 20 mg, followed by omeprazole 40 mg. Other significant cost variations (>100%) were seen with pantoprazole 40 mg, Downoprazol (omeprazole + sodium bicarbonate) 40 mg, and esomeprazole 40 mg. Ampoules of omeprazole, cimetidine, and ranitidine had cost ratios of 1:1.7, 1:1.7, and 1:1.8, and cost variation ratios of 71.4, 66.7, and 75, respectively. Variations in prices of PPI and histamine H2 antagonists from the same manufacturer between different community pharmacies were common. The highest percentage cost variation (100) was seen with omeprazole 20 mg.
Conclusions: Due to political instability, the prices of all drugs are controlled by importing private companies and the owners of community pharmacies instead of governmental authorities, that leads to cost variations. Therefore, the health authorities exert strict control on pricing of medications.
Comparative study of efficacy and safety of pregabalin and gabapentin for treatment of neuropathic pain in oral cavity cancer patients: a comparative, randomized and prospective study
Authors: Saji Sreeharsh , Singhal Yogendra , Pingoliya Surendra Kumar
Published: June 2024

Background: Pain in patients with oral cancers can limit the normal functioning and quality of life. Neuropathic pain raises the anxiety and depression levels, increases the morbidity and decreases the efficiency to work. Neuropathic pain is frequently diagnosed as a complication of cancer pain due to direct invasion of nerves, plexus or compression, and side effect of chemotherapy, radiation injury or surgery.
Methods: A total of 60 patients were divided randomly into two groups based on treatment: group P (pregabalin) and group G (gabapentin). The intensity of pain was measured using visual analog scale (VAS) and DN4 questionnaire (Douleur Neuropathique 4) was used to evaluate neuropathic component. Changes in pain score and neuropathic component was assessed at 2nd and 4th week of follow up. Data was collected and analysed using SPSS 20.0 software at level of significance being p<0.05.
Results: At baseline, the mean±SD of VAS score in group P was 7.20±0.79; in group G was 7.13±0.66. At 2nd week, the mean±SD of VAS score in group P was 4.5±0.91; in group G was 4.46±0.88. At 4th week, the mean±SD of VAS score in group P was 3.66±0.69; in group G was 3.83±0.85. At baseline, the mean±SD of DN4 score in group P was 7.13±0.80; in group G was 6.93±0.85. At 2nd week, the mean±SD of DN4 score in group P was 4.73±0.92; in group G was 4.46±0.82. At 4th week, the mean±SD of DN4 score in group P was 3.73±0.42; in group G was 3.93±0.62.
Conclusions: Pregabalin was found to be more effective with lesser side effects than gabapentin.
Antihypertensive drug prescription patterns and their impact on blood pressure outcomes in a tertiary care teaching hospital
Authors: Kedare Rahul K. , Pujari Avinash Janardan , Hivale Nitin , Kharat Rajesh
Published: June 2024

Background: The guidelines from the Joint National Committee (JNC-8) emphasize the importance of rapid blood pressure (BP) control to reduce morbidity and mortality. The success of hypertension treatment depends on various factors, with irrational prescription being strongly linked to poor BP control. This study aimed to evaluate the patterns of antihypertensive drug prescriptions among patients in a tertiary care teaching hospital.
Methods: A hospital-based observational study was conducted in 2018, including all hypertensive patients on medication. Their prescription patterns were analyzed.
Results: The study analyzed prescriptions from 240 hypertensive patients. The mean ages for male and female patients were 56.68±15.32 and 62.29±12.65 years, respectively. Physicians commonly prescribed monotherapy (34.60%) followed by two-drug (18.40%), three-drug (11.80%), and four-drug combinations (3.00%). The most frequent two-drug combination was ACE inhibitors + diuretics (4.40%), followed by angiotensin receptor blockers (ARBs) + diuretics (3.60%) and calcium channel blockers (CCBs) + ACE inhibitors (2.60%). Adherence to JNC 8 guidelines was 19.3% for pre-hypertension, 88.70% for stage 1 hypertension, and 73.29% for stage 2 hypertension.
Conclusions: Monotherapies were the most commonly prescribed regimens. Twice-daily dosing and monthly appointments were associated with lower incidences of uncontrolled BP. However, complete adherence to standard guidelines was not observed in all cases, especially in patients with comorbid conditions.
A rare presentation of adult Bartter syndrome: a case report
Authors: B. S. Sreelekshmy , S. R. Ranjana , Dharman Dhanya , Dharan Shaiju S.
Published: June 2024

Bartter syndrome (BS) is an inherited renal tubular disease. It is caused by a defective salt reabsorption in the thick ascending limb of loop of Henle. The term BS signify a group of renal disease which is the common divisor of hypokalemia and metabolic alkalosis. BS is categorized into 5 types based on the specific channel; type 1 is linked to gene SLC12A1, type 2 is linked to a gene KCNJ1, type 3 is linked to a gene called CICNKb while type 4 is linked to a gene BSND and type 5 is linked to CASR gene. This disorder is correlated with an increased antenatal and neonatal mortality. Here, a 61 years old female patient was presented with complaints of fever, myalgia, nausea, and cough for one day, decreased appetite and unable to do daily routine. Patient had conscious, oriented and afebrile. She had history of OAD, type 2 diabetes mellitus and hypertension. On hospital stay, she was started on IV calcium gluconate, potassium chloride, magnesium sulphate, antipyretics and other supportive measures. This case concludes the rarity of the BS. Correct diagnosis of BS is more expensive and not routinely available genetic testing. Therefore, the significance of diagnosing the case is more relevant.
A comparative study of cord blood lipid profile in term, pre term and small for gestational age - appropriate for gestational age neonates
Authors: Ramanathan  , Raguraman Thivyabharathi
Published: June 2024

Background: Cord blood lipid profile in neonates helps to screen for neonatal dyslipidaemia which is associated with long term morbidity mainly cardiovascular disease.
Methods: The present study is a observational study done in government medical college, Chidambaram for a period of 2 years from October-2020 till September-2022 with 222 term and pre-term small or appropriate for gestational age (AGA) neonates using cord blood lipid profile.
Results: In the present study of above mentioned 222 neonates, preterm accounts for 30.1% and term neonates accounts for 69.9%. AGA was 63.1% and SGA was 36.9%. Term AGA was 38.2%, term SGA 31.5%, preterm AGA was 24%, preterm SGA was 5.4%. 
Conclusions: Preterm AGA had higher cord lipid profile values compared to the term AGA neonates. Preterm SGA neonates had lower cord lipid profile of HDL, and LDL as compared to preterm AGA neonates. SGA neonates had higher total cholesterol, triglycerides and VLDL compared to AGA neonates. SGA neonates had lower LDL and HDL as compared to AGA neonates.