bluuebunny/crossref_metadata_2025 huggingface dataset:
First-line treatment for driver gene–negative metastatic lung adenocarcinoma with malignant pleural effusion: Should chemotherapy be combined with an immune checkpoint inhibitor or bevacizumab？
Authors: Zhao Yuanyuan , Mei Ting , Na Feifei , Tian Xiaoman , Ao Rui , Long Xiangyu , Luo Qiang , Duan Ping , Zhu Jiang , Wang Yongsheng , Huang Meijuan , Liu Yongmei , Gong Youling
Published: September 2023

Introduction:
Patients with metastatic lung adenocarcinoma (MLA) and malignant pleural effusion (MPE) without driver gene mutations have a poor prognosis. None of the standard treatment strategies are recommended for such patients. We retrospectively analyzed the efficacy of the first-line treatment for this specific population: standard platinum-based doublet chemotherapy (CT), CT plus an immune checkpoint inhibitor (CT + ICI) and CT plus antiangiogenic agents (CT + Bev).
Methods
A total of 369 eligible patients were enrolled: CT alone (n = 201), CT + Bev (n = 83), and CT + ICI (n = 85). Treatment efficacy assessments were performed every two cycles according to the RECIST guidelines. The endpoints were overall survival (OS) and progression-free survival (PFS). Kaplan‒Meier curves and the log-rank test were used to compare OS and PFS. p < 0.05 was the threshold of significance (statistical software: SPSS).
Results
The median follow-up was 11.4 months (range of 2.1–49.6 months). PFS and OS in the CT + ICI/CT + Bev cohort were significantly longer than those in the CT group (PFS: 7.7/7.4/4.6 months, p = 0.001; OS: 18.5/17.8/10.9 months, p < 0.001, respectively). CT + Bev had better PFS and OS than CT + ICI/CT in PD-L1 < 1% patients (PFS: 8.4/4.8/4.8 months, p = 0.029; OS: 15.5/12.9/9.8 months, p = 0.002). Among patients with PD-L1 1–49%, CT + ICI led to a longer PFS and OS (PFS: 8.8/6.4/4.2 months, p = 0.002; OS: 34.1/21.0/11.5 months, p = 0.049). In the cohort with PD-L1 ≥ 50%, CT + ICI was still the best first-line treatment (PFS: 19.9/9.4/8.0 months, p = 0.029; OS: 30.2/15.5/13.0 months, p = 0.034).
Conclusion
In driver gene–negative MLA with MPE, CT + Bev or ICI better controlled MPE and significantly prolonged survival compared to chemotherapy alone. PD-L1 expression (negative/positive) might be a key factor influencing the choice of CT plus Bev or ICI.
Diastolic/systolic blood pressure ratio for predicting febrile children with sepsis and progress to septic shock in the Emergency Department
Authors: Mu Chun-Ting , Lin Ying-Jui , Chen Chih-Ho , Hsia Shao-Hsuan , Lin Jainn-Jim , Chan Oi-Wa , Yen Chen-Wei , Chiu Chun-Che , Chang Han-Pi , Su Ya-Ting , Lee En-Pei
Published: September 2023

Objective Given the scarcity of studies analyzing the clinical predictors of pediatric septic cases that would progress to septic shock, this study aimed to determine strong predictors for pediatric emergency department (PED) patients with sepsis at risk for septic shock and mortality.Methods We conducted chart reviews of patients with ≥ 2 age-adjusted quick Sequential Organ Failure Assessment score (qSOFA) criteria to recognize patients with an infectious disease in two tertiary PEDs between January 1, 2021, and April 30, 2022. The primary outcome was meeting the criteria of septic shock within 96 h of PED attendance. The secondary outcome was sepsis-related 28-day mortality. Initial important variables in the PED and hemodynamics with the highest and lowest values during the first 24 h of admission were also analyzed.Results Overall, 417 patients were admitted because of sepsis and met the eligibility criteria for the study. Forty-nine cases progressed to septic shock within 96 h after admission and 368 were discharged without progression. General demographics, laboratory data, and hemodynamics were analyzed by multivariate analysis. Only the minimum diastolic blood pressure/systolic blood pressure ratio (D/S ratio) during the first 24 h after admission remained as an independent predictor of progression to septic shock and 28-day mortality. The best cutoff values of the D/S ratio for predicting septic shock and 28-day mortality were 0.52 and 0.47, respectively.Conclusions The D/S ratio is a practical bedside scoring system in the PED and had improved specificity in detecting septic shock early and predicting in-hospital mortality. Further validation is essential in other settings.
Mendelian Randomization Reveal Causal Relationship Between Periodontitis and Coronary Atherosclerosis
Authors: Li Zhengrui , Wang Qi , Huang Xufeng , Wu Yinteng , Fu Rao , Wen Xutao , Liu JiAn , Chen Yuanguo , Liu Ying , Zhang Ling
Published: September 2023

Objectives
Growing evidence appears to intimate a profound connection between periodontitis and coronary atherosclerosis (CA), yet the existence of a causal relationship remains unclear. Through the implementation of Mendelian randomization analysis, We further evaluated the potential causal link between chronic/acute periodontitis (CP/AP) and CA.
Objectives
Utilizing genome-wide association study (GWAS) summary statistics, we incorporated periodontitis data derived from European samples (n1 = 198,441; n2 = 195,762) and CA data from 61,194 cases. We conducted a two sample, bidirectional Mendelian randomization (MR) analysis using the inverse-variance weighted (IVW) method as the main analytical approach. Supplementary analyses were executed through MR Egger, Weighted median (WM), IVW, Simple mode, and Weighted mode approaches.
Results
The IVW analysis revealed no significant causal relationship between CA and periodontitis (CA-CP: OR = 2.110, 95% CI = 1.483–3.003, P = 0.527; CA-AP: OR = 0.414, 95% CI = 0.051–3.384, P = 0.644). Similarly, the bidirectional analysis did not identify impact of periodontitis on CA (OR = 1.000, 95% CI = 0.999–1.001, P = 0.953). The supplementary analyses corroborated these findings.
Conclusions
While studies highlighting a correlation between periodontitis and CA, our comprehensive analysis does not corroborate a causal connection between periodontitis and CA. Further research is needed to elucidate other potential shared mechanisms and causal evidence between periodontitis and CA.
Design of Intelligent Filtering Mechanism using SAF for Industrial Power Quality Perturbations
Authors: R Raja Singh , Shrivastava Riya , Kodnani Jigyasa , R Manikandan , D Shruthi , R Rengaraj
Published: September 2023

This paper presents a smart switching mechanism to optimize and control of industrial shunt active power filters. The aim is to design a low-cost shunt active filter with a reliable switching mechanism that integrates to industrial loads at the point of common coupling. Traditionally, the shunt active power filter is linked to all of the system's loads. The size and capacity of the shunt active filter can be decreased by connecting fewer loads. In industries, some loads don't contribute much to harmonic distortion and maybe overlooked while compensating for it. The smart switching mechanism has been used to categorise necessary loads based on two constraints: individual load THD and shunt active filter peak current at a particular instance. This switching mechanism is implemented using the classification learner application in Matlab. Smart switching connects the appropriate loads to the shunt active power filter automatically. The shunt active filter is optimized using Fuzzy Logic-DC voltage control. The Matlab/ Simulink simulation model was developed to test the effectiveness of the above-mentioned strategy.
Prevalence of high-risk human papillomavirus infection, associated risk factors, and relationship with cervical precancerous lesions in perimenopausal and older women in an area with high cervical cancer incidence in China
Authors: Zhang Ruoyi , Kang Dan , Yang Siyuan , Hu Dehua , Bai Li , Nie Yuxian , Xiang Rumei , Zhao Xiaowei , Xu Wei , Shi Qiuling
Published: September 2023

Introduction:
Cervical cancer is the fourth most diagnosed cancer globally. Its incidence differs across regions and age groups. Hence, while its incidence is reducing in China, Lueyang County, Shaanxi Province, presents a persistent challenge. Therefore, this study aims to investigate the prevalence of high-risk human papillomavirus (HR-HPV) infection, its influencing factors, and the incidence of cervical-associated lesions in perimenopausal and elderly women (aged 40–65 years) in Lueyang County, Shaanxi Province, China. Additionally, it explored the association between HR-HPV infection and precancerous lesions.
Materials and Methods
Overall, 2008 women underwent human papillomavirus (HPV) genotyping, while 342 underwent cytological examination. The main outcome indicators were the prevalence of HPV and precancerous lesions and predictors of HR-HPV infection.
Results
The prevalence of HR-HPV infection among women aged 40–65 years in Lueyang County was 18.43%. Older women exhibited a higher incidence of HPV infection, abnormal ThinPrep Pap Test (TBS) results, and low/high-grade squamous intraepithelial lesions (LSIL/HSIL) (P < 0.05). The most prevalent HR-HPV genotypes in the overall, perimenopausal, and elderly groups were HPV-52, -53, and − 58; HPV-52, -53, and − 16; and HPV-58, -52, and − 53, respectively. The prevalent HR-HPV genotypes in the abnormal TBS results were HPV-16, -52, -33, -58; -16, -52, -58; and-16, -33, and − 52. HPV-16, -18, -33 prevalence increased with increasing lesion severity (P < 0.05). Independent factors influencing HR-HPV were associated with sexual behavior and education level.
Conclusions
These findings suggest that the elevated rate of abnormal TBS in the older age group may be attributed to the higher prevalence of persistent infection-prone HR-HPV genotypes (HPV-58, -52, and-53), multiple infections, and potent oncogenic HR-HPV genotypes (HPV − 16 and − 33). Additionally, the higher HR-HPV prevalence in older patients may be related to lower education attainment, reduced screening rate, and limited condom usage. Therefore, strategies targeting perimenopausal and older women should prioritize enhancing health awareness, increasing screening rates, and encouraging condom utilization.
Racial discrimination and Aboriginal and Torres Strait Islander suicide mortality rates in Queensland
Authors: Gibson Mandy , Kõlves Kairi , Ward Raelene , Leske Stuart , Rachow Amanda
Published: September 2023

Objective: The study aimed to examine the associations of experiences of racial discrimination within communities with suicide mortality rates for Aboriginal and Torres Strait Islander people.
Methods: Age‐standardised suicide rates (ASRs) were calculated using suicides recorded by the Queensland Suicide Register (QSR) of Aboriginal and Torres Strait Islander people in Queensland from 2001–2015. Rate Ratios (RRs) were used to compare ASRs in areas with high and low levels of reported discrimination, and other comparative community-level risk and protective factors (remoteness, socio-economic resources, and Indigenous language use).
Results: The age-standardised suicide rate was 31.74 deaths per 100 000 persons/year for Aboriginal and Torres Strait Islander people. ASRs were significantly in areas where more of the First Nations residents experienced recent discrimination (RR=1.33; 95%CI=1.05–1.70, p=0.02), and the age-specific suicide rate was significantly higher for those aged 25-34 in areas with more discrimination (RR=1.67; 95%CI=1.04–2.74, p=0.03). By comparison, the ASRs were not significantly higher in areas with regional and remote communities (RR=1.10, CI 95%=0.75–1.61, p=0.6), or areas with lower socioeconomic resources (RR=0.86, 95%CI=0.66–1.13, p=0.28). Areas in which more First Nations residents spoke Indigenous languages had significantly lower ASRs (RR=1.51; CI95%=1.08–2.10, p=0.02).
Conclusion: Suicide mortality rates for Aboriginal and Torres Strait Islander people in Queensland were influenced by experiences of racial discrimination within communities, with greater associations reported than with socio-economic resources or remoteness. The findings reflect the public health risk of discrimination and provide evidence for enacting strategies to reduce institutional and personal discrimination to reduce suicide.
DeVi Deep Learning Framework for Misogyny Identification in Multimodal Data
Authors: Singh Nitin Kumar , Das Prativa , Manderna Ankit , Chand Satish
Published: September 2023

In recent times, there has been a notable upsurge in the frequency of memes across a wide range of social media platforms. Memes provide amusement to people with their humour, but unfortunately, some memes exploit this humour as a cover to spread misogynistic and hateful content targeting women on online platforms. Most of the previously proposed methods for detecting misogyny have primarily concentrated on either textual or visual content. However, there is a noticeable dearth of research on analysing multimodal data that combines both images and text. We propose a DeVi framework comprising DeBERTa and Vision Transformer with an attention-based late fusion strategy for automatic misogyny identification in memes. We evaluated the proposed framework on two different subtasks provided in SemEval-2022 task 5 on the MAMI dataset. Subtask A is a misogynous meme identification task, and subtask B is to identify the type of misogyny, which is a multilabel classification task. The proposed framework achieved an F1-score of 0.865 and 0.783 on subtask A and B, respectively. The experimental findings clearly illustrate that the DeVi framework we propose outperforms existing multimodal models in both subtasks, showcasing its superior performance. This highlights the effectiveness and adaptability of the DeVi framework.
Dynamin-dependent entry of Chlamydia trachomatis is sequentially regulated by the effectors TarP and TmeA
Authors: Carabeo Rey , Romero Matthew
Published: September 2023

Chlamydia invasion of epithelial cells is a pathogen-driven process involving two functionally distinct effectors – TarP and TmeA. They collaborate to promote robust actin dynamics at sites of entry. Here, we extend studies on the molecular mechanism of invasion by implicating the host GTPase dynamin 2 (Dyn2) in the completion of pathogen uptake. Importantly, Dyn2 function is modulated by TarP and TmeA at the levels of recruitment and activation through oligomerization, respectively. TarP-dependent recruitment requires phosphatidylinositol 3-kinase and the small GTPase Rac1, while TmeA has a post-recruitment role related to Dyn2 oligomerization. This is based on the rescue of invasion duration and efficiency in the absence of TmeA by the Dyn2 oligomer-stabilizing small molecule activator Ryngo 1-23. Notably, Dyn2 also regulated turnover of TarP- and TmeA-associated actin networks, with disrupted Dyn2 function resulting in aberrant turnover dynamics, thus establishing the interdependent functional relationship between Dyn2 and the effectors TarP and TmeA.
Generalized group elements and their orders
Authors: Chen Huanyin , Sheibani Marjan
Published: September 2023

In this paper, we present reverse order of generalized group inverse in a proper Banach algebra. We characterize generalized group elements and determine when an element and its generalized group inverse commute each other. The properties of the generalized group orders are investigated. As applications, new properties of the core-EP order of two complex matrices and Hilbert space operators are thereby extended to wider cases.
2020 Mathematics Subject Classification. 15A09, 16U99, 46H05.
CARCINOMEEPIDERMOIDEDU SCALP:APROPOSDUNCASMULTI-COMPLIQUE.SQUAMOUSCELLCARCINOMAOFSCALP: ACASEREPORTOF APATIENT WITH MULTIPLE COMPLICATIONS
Authors:   Plastic Surgery Department, University Hospital Of Mohammed Vi Marrakech., Sahir M. , a Marzak ,   Plastic Surgery Department, University Hospital Of Mohammed Vi Marrakech., b Salome ,   Plastic Surgery Department, University Hospital Of Mohammed Vi Marrakech., c Benlaguide ,   Plastic Surgery Department, University Hospital Of Mohammed Vi Marrakech., a Sylla ,   Plastic Surgery Department, University Hospital Of Mohammed Vi Marrakech., b Azzouzi ,   Plastic Surgery Department, University Hospital Of Mohammed Vi Marrakech., c Alami ,   Plastic Surgery Department, University Hospital Of Mohammed Vi Marrakech., a Lamaalla ,   Plastic Surgery Department, University Hospital Of Mohammed Vi Marrakech., b Idelkheir ,   Plastic Surgery Department, University Hospital Of Mohammed Vi Marrakech., Eddine Zine ,   Plastic Surgery Department, University Hospital Of Mohammed Vi Marrakech., Benlaassel Ait ,   Plastic Surgery Department, University Hospital Of Mohammed Vi Marrakech., O. Elatiqi Ass. ,   Plastic Surgery Department, University Hospital Of Mohammed Vi Marrakech., El Amrani MD. ,   Plastic Surgery Department, University Hospital Of Mohammed Vi Marrakech., Benchamkha Y. ,   Plastic Surgery Department, University Hospital Of Mohammed Vi Marrakech.
Published: September 2023

Squamous cell carcinoma of the scalp is frequent in our field of practice. Nevertheless, we report the case of a patient who had consulted at a locally advanced stage of the tumour. The patient was being monitored in our department and had almost all the critical complications of cancer in an elderly patient. Pathology examination confirmed the diagnosis. Treatment was dependent on the stage of the lesion and its location. The prognosis remained bleak. However, our hope for this patient relied on therapeutic protocols combining carcinological surgery first followed by adjuvant chemotherapy. This is a rather exceptional clinical case because of the multiple complications the patient had: 1. Thromboembolic 2. Infectious 3. Rapid tumor recurrence after 15 days 4. None cooperative patient due to inability to support post-operative dressings 5. Depressive disorders due to long length of hospitalization 6. Death The rarity of the combination of all these complications has caused us therapeutic problems. Therefore, we highlight the importance of screening and management of tumours at an early stage.
Discrete-event modelling of container terminal cargo fronts
Authors: Kuznetsov A. L. , Galin A. V. , Popov G. B.
Published: September 2023

The basis for designing and upgrading new sea ports and container terminals is regulatory documentation. A part of designing a new sea port is making key technological decisions, including on calculating its cargo throughput capacity. However a method for capacity evaluation of operating ports is not described in the regulatory documents. Operating cargo terminals often undergo significant changes since the moment they were put into operation. Equipment, resources and infrastructure of cargo fronts should not be the only thing taken into consideration when evaluating an existing container terminal capacity. The way in which a terminal interacts with external transport systems (railroad, vessel fleet, etc.) as well as interactions between cargo fronts inside a terminal should also be considered. A discrete- event simulation model for the system consisting of a railroad cargo front, a container yard and a berth cargo front of a container terminal is proposed in the paper. This model allows to evaluate the balance between calls of different modes of transport (vessel calls, cargo train calls), as well as the impact of this balance on the state of container yard and on the terminal cargo throughput capacity in general. Container terminal in terms of proposed model is not merely a set of unrelated objects, but a system. In such system interaction with one of elements has influence on all the others. The model is described as mathematical dependencies between key variables. Cargo train and vessel calls generation is performed via standard spreadsheet methods. To acquire more accurate results, specific sea port statistical data should be used.
139 The impacts of technological innovation and institutional quality on the productivity of Vietnamese manufacturing firms
Authors: Dinh Quang Thai , Nguyen Manh Trong , Quach Ha Thi , Vo Quy Tam Thuy , Nguyen Van
Published: September 2023

This research aims to assess the pivotal role of total factor productivity (TFP) in shaping the performance of manufacturing enterprises in Vietnam. It systematically examines the influence of technological innovation and the quality of economic institutions on the TFP of these firms. Employing robust methodologies such as control function (CF) and feasible generalized least squares regression (FGLS) models, a comprehensive panel dataset of Vietnamese manufacturing companies is meticulously scrutinized. The data, meticulously sourced from the General Statistics Office of Vietnam and the Vietnam Chamber of Commerce and Industry, spans the five-year period from 2015 to 2019. The findings of this study elucidate several key insights. First, it reveals that the manufacturing landscape in Vietnam is predominantly characterized by labor-intensive operations, with an apparent trend toward increasing returns to scale. Furthermore, the study underscores that TFP's contribution to manufacturing output remains relatively modest, averaging at 1.933 over the period from 2015 to 2019. Additionally, it identifies a concerning decline in the average TFP score, along with a widening gap between firms, which tends to exacerbate during the study period. Finally, the research establishes a positive correlation between investments in production technology and the quality of economic governance within provincial governments in Vietnam, both of which significantly bolster the TFP of manufacturing firms.
Effect of gender sensitivity on attitudes toward marriage and childbirth among university students in South Korea
Authors: Kim Jae Hee
Published: September 2023

This research delves into the intricate domain of gender sensitivity, a cognitive process rooted in the awareness of gender equality and the ability to actively endorse and practice it. The study focuses on a cohort of university students on the brink of marriageable and childbearing age, aiming to scrutinize the potential influence of gender sensitivity on their attitudes towards marriage and childbirth. Employing a convenience sampling method, 196 students spanning from first to fourth-year were enlisted as participants. Data were collected through online surveys conducted between April 5 and April 12, 2022. Our findings illuminate that male participants harbor a more affirmative disposition towards both marriage and childbirth compared to their female counterparts. Moreover, a significant positive correlation surfaces between attitudes towards marriage and childbirth. Intriguingly, the study exposes a notable inverse relationship between gender sensitivity and attitudes towards marriage (β = -.49, t = -7.13, p < 0.001) as well as childbirth (β = -.44, t = -6.45, p < 0.001). In light of these revelations, the study underscores the paramount importance of integrating gender sensitivity into strategies aimed at enhancing university students' perspectives on marriage and childbirth. Moreover, it advocates for a policy-oriented approach to ameliorate gender inequality on a societal scale. The study's profound significance lies in its revelation that, in a society lacking in gender sensitivity, the prevalence of marriages and fertility rates may exhibit a negative correlation with gender sensitivity. This underscores the imperative need for sustained governmental efforts to augment gender sensitivity.
Clinical Case of Mccune-Albright-Braitsev Syndrome (MAS)
Authors: Valeeva F. V. , Kiseleva T. A. , Shaidullina M. R. , Islamova D. R. , Gumerova A. K.
Published: September 2023

The presented clinical case describes orphan disease known as MAS with manifested symptoms of precocious puberty, recurrent ovarian cysts, fibrous dysplasia, café-au-lait skin pigmentation and abnormal cardiac conduction. The pathogenesis is based on the GNAS gene mutation that cause hyperactivation of glycoprotein hormone receptors and hypersecretion. There are genetic tests that confirm the diagnosis, however, given the high percentage of false negative results, in most cases the disease is diagnosed based on a combination of clinical and laboratory-instrumental data. Given the high clinical variability and absence of management algorithms for patient with this syndrome, the article pinpoints the necessity of thorough examination of patients to select further management tactics. Multidisciplinary approach and collegiate case management will improve diagnosis of the disease and prevent the development of severe complications.
Vaginal and endometrial microbiome: evaluation, effect on embryo implantation
Authors: Kutsenko I. I. , Borovikov I. O. , Kravtsova E. I. , Bulgakova V. P. , Borovikova O. I. , Cheremnykh R. V. , Andreeva A. A. , Borovikov M. I.
Published: September 2023

Objective: assessment of the microbiome of the vagina and uterine cavity using a uterine catheter with a collet guide in infertile patients before the in vitro fertilization procedure. Materials and methods: samples of vaginal and endometrial scrapings obtained from 73 infertile women who had planned an in vitro fertilization (IVF) procedure were taken and studied. The samples were analyzed by V3-V4-V6 regions using the 16S rRNA gene sequencing method. Results: significant differences were found in the taxonomy of the endometrium and vaginal microbiome - coincidences in microbiological composition were detected in 18.2% of patients. Endometrial lactobacillus-dominant microbiocenoses occurred in 24.8% of women, vaginal — in 56.7%. Comparisons between patients with negative and positive IVF (onset of biological pregnancy) results failed to identify any microorganism associated with the success of the procedure, with endometrial microbiota biodiversity being higher among women who successfully exercised their reproductive function. The Shannon Equality Index (J) for pregnant and non-pregnant women was 0.76 (0.57–0.87) and 0.55 (0.51–0.64), respectively (p=0.002). Conclusion: the use of a developed uterine catheter with a collet guide for an adequate assessment of the endometrial microbiome is promising and justified. The correct assessment of the endometrial microbiocenosis contributes to the adequate diagnosis of pathological processes occurring in the uterine cavity, which will allow for proper therapy aimed at increasing the receptivity of the endometrium and, in the future, contributing to the realization of the reproductive function of a woman.
Microwave radiothermometry of knee joints in girls in pre- and pubertal periods
Authors: Tarakanov A. V. , Lebedenko A. A. , Ladanova E. S. , Tarakanova T. D. , Skorodumova E. G. , Yatsuk A. N.
Published: September 2023

Objective: to study the deep and skin temperatures of the knee joint by microwave radiothermometry (RTM) in healthy girls of comparable age in the pre- and pubertal periods. Materials and methods: the study was carried out in the "Problem Scientific Laboratory of Physical Methods of Diagnosis and Treatment" of Rostov State Medical University and the children's health camp "Mir" (Krasny Desant village, Rostov region). It was 45 girls aged 12 years, taking into account gender development, divided into two groups: 1st gr. (n=28)  — prepubertal period; 2nd gr. (n =17) — puberty. RTM of the knee joints was performed according to a certain scheme using the MWR2020 system (ex RTM-01-RES) (Moscow, Great Britain). Results: in the groups, the color fields of deep and skin temperature, when compared, are characterized by a slight geometric and color transformation are similar to each other; the lowest temperature is noted in the projection of the patella. Temperature fields of thermoasymmetry make it possible to reveal temperature differences in groups of subjects. In the 2-nd group, there are also higher growth and weight indicators, lower deep and skin temperature in almost all areas of the knee joint, fluctuations reach 0.4 –1.4 ° C. Conclusion: a decrease in temperature in the knee joints in pubertal girls with a relatively mature menstrual cycle reflects general changes in hormonal regulation in this period of development. When forming the temperature indicators of healthy girls, it is necessary to take into account the hormonal processes of puberty with division into groups of pre- and pubertal periods of development.
Epizootic and epidemiological situation of hemorrhagic ever with renal syndrome in the Rostov region (2020–2022)
Authors: Bereznyak E. A. , Trishina A. V. , Pichurina N. L. , Egiazaryan L. A. , Simonova I. R. , Dobrovolsky O. P. , Liakh O. V. , Kuznetsov D. V. , Noskov A. K.
Published: September 2023

Objective: evaluation of the epizootic and epidemiological situation for HFRS in the Rostov region. Materials and methods: from 2020 to 2022, an enzyme-linked immunosorbent assay was used to study the presence of hantavirus antigens in samples of small mammals and class G immunoglobulins in the blood sera of healthy donors. Results: epizootological monitoring conducted in 35 administrative districts of the region and in the vicinity of Rostov-on-Don (2157 animals, 15 species) revealed the circulation of hantaviruses in populations of small mammals. Infection with hantaviruses of six species of mammals was registered: house mouse, common vole, yellow-bellied mouse, European forest mouse, East European vole, small forest mouse. 1062 blood samples from residents of various regions of the region were tested. Class G antibodies to hantaviruses were detected in 7.0%, 4.5%, 7.1% in different years. Conclusions: the coincidence in the territories of Azovsky, Kamensky, Neklinovsky, Salsky, Morozovsky districts of positive findings of the hantavirus antigen in samples of small mammals and seropositive samples of donors suggests the presence of a natural focus of HFRS, the establishment of boundaries and activity of which needs further research.
Procedure for obtaining flour from Canavalia ensiformis (L) seeds
Authors: Rodríguez - Quiñones Pavel , Pérez Martínez Aurora Terylene , Fontes Marrero Dayami , Pérez Gómez Liannis , Martínez Montero Marcos Edel , Zambrano Muñoz Denisse Margoth , Solis Natalys , Bolaños Velez Cristóbal Ismael
Published: September 2023

Legume seeds are rich in protein, making them useful in various biotechnological processes, such as protein hydrolysates, with different uses based on biological activity. These bioproducts can be used as agricultural biostimulants due to their ability to improve nutrient absorption and assimilation processes, biotic and abiotic stress tolerance, and agronomic indicators of crops. Among tropical legumes, Canavalia ensiformis (L.) is a promising crop because of its adaptability to various soil and climate conditions, high germination rate, and agricultural yield. This study aimed to establish a technological procedure for producing C. ensiformis seed flour to use as a protein source for agricultural biostimulant production. The seeds underwent an 84-h imbibition process in running water, and the water absorption index and percentage of seeds that experienced plasmolysis were determined, with indicators evaluated every 12 h. The seed coat was removed, and the cotyledons were dried in an oven at 60°C for 24 h, establishing the drying curve and productive yield. The resulting flour from the 72-h imbibition process was analyzed for particle size, techno-functional and chemical properties, which were compared to the flour of whole seeds. The study showed that the procedure improved the techno-functional and chemical properties of the flour and its effectiveness in obtaining flour easily and cost-effectively.
Keywords: absorption, imbibition process, flour, seeds.
Dying process by COVID-19 in intensive care patients: visibility of the nursing professional
Authors: Ortiz Vega Mariela Lizeth , López Andrade Jonathan Alexis , Jimenez Barrera Maricelys , Herrera Sánchez Priscila Jaqueline , Muñoz Guanga Alisson Patricia , Herrera Navas Cristopher David
Published: September 2023

La pandemia de COVID-19 ha provocado una alta mortalidad en pacientes de UCI, causando un impacto emocional y psicológico en los profesionales de enfermería que trabajan en estas unidades. Este estudio tuvo como objetivo analizar la percepción de los profesionales de enfermería ante el proceso de muerte de pacientes por COVID-19 en la UCI. La metodología utilizada tiene un enfoque cualitativo de método descriptivo y enfoque fenomenológico; se entrevistaron 10 profesionales de enfermería a través de un muestreo no probabilístico por conveniencia. Como resultado se obtuvieron seis categorías: la percepción de los profesionales de enfermería hacia el proceso de morir, la atención humanizada al paciente durante el proceso de morir, la necesidad de formación de los profesionales de enfermería durante la pandemia y la incertidumbre sobre el distanciamiento social de los pacientes con COVID-19. La falta de experiencia en el manejo de pacientes con COVID-19 ha provocado vulnerabilidad en el estado psicológico y emocional de los profesionales de enfermería. Concluimos resaltando la necesidad de una adecuada formación, protocolos y apoyo a los profesionales de enfermería que trabajan en las unidades para mejorar la atención a los pacientes y el bienestar del personal sanitario.
Palabras clave: Pandemia; aislamiento social; muerte; cuidados
Percepción de la asistencia médica, en usuarios atendidos en emergencia de un hospital público de Manabí
Authors: Guerrero Pin Carlos Enrique , Piñon Gámez Aimee , Carranza Domínguez Arely Priscilla , Ávila Zambrano Cristóbal Josué , Carballosa Velezquez Elizabeth
Published: September 2023

La percepción de los usuarios con la atención médica es de causa multifactorial y puede expresarse con criterios de satisfacción, lo cual es un indicador de calidad en la atención médica del sistema de salud, por lo que el objetivo del estudio fue describir la percepción de la atención médica, en usuarios atendidos en emergencia de un hospital público de Manabí. La metodología se basó en un estudio cuantitativo, descriptivo, transversal, realizado en el servicio de emergencia, el presente año; Se aplicó el cuestionario “SERVQUAL” previamente validado a la muestra de 381 usuarios, con muestreo aleatorio simple. Los resultados sobre la percepción de la atención médica indicaron que la mayoría de los usuarios expresaron "buena" satisfacción, los servicios prestados mostraron "buenos" criterios en tiempo de respuesta para exámenes complementarios, higiene de las áreas y proceso de triaje, pero la disponibilidad de medicamentos en farmacia reportaron criterios de "regular" en más de la mitad de los encuestados. La conclusión indicó que la percepción de los usuarios con la asistencia médica fue categorizada como buena en la mayoría de los usuarios, en cambio, el beneficio (disponibilidad de medicamentos en farmacia) fue calificado como regular.
Palabras claves: atención médica; satisfacción; calidad de servicio.
Development, Reliability, and Structural Validity of the Scale for Knowledge, Attitude, and Practice in Ethics Implementation Among AI Researchers: Cross-Sectional Study
Authors: Zhang Xiaobo , Gu Ying , Yin Jie , Zhang Yuejie , Jin Cheng , Wang Weibing , Li Albert Martin , Wang Yingwen , Su Ling , Xu Hong , Ge Xiaoling , Ye Chengjie , Tang Liangfeng , Shen Bing , Fang Jinwu , Wang Daoyang , Feng Rui
Published: September 2023

Background

Medical artificial intelligence (AI) has significantly contributed to decision support for disease screening, diagnosis, and management. With the growing number of medical AI developments and applications, incorporating ethics is considered essential to avoiding harm and ensuring broad benefits in the lifecycle of medical AI. One of the premises for effectively implementing ethics in Medical AI research necessitates researchers' comprehensive knowledge, enthusiastic attitude, and practical experience. However, there is currently a lack of an available instrument to measure these aspects.

Objective

The aim of this study was to develop a comprehensive scale for measuring the knowledge, attitude, and practice of ethics implementation among medical AI researchers, and to evaluate its measurement properties.

Methods

The construct of the Knowledge-Attitude-Practice in Ethics Implementation (KAP-EI) scale was based on the Knowledge-Attitude-Practice (KAP) model, and the evaluation of its measurement properties was in compliance with the COnsensus-based Standards for the selection of health status Measurement INstruments (COSMIN) reporting guidelines for studies on measurement instruments. The study was conducted in 2 phases. The first phase involved scale development through a systematic literature review, qualitative interviews, and item analysis based on a cross-sectional survey. The second phase involved evaluation of structural validity and reliability through another cross-sectional study.

Results

The KAP-EI scale had 3 dimensions including knowledge (10 items), attitude (6 items), and practice (7 items). The Cronbach α for the whole scale reached .934. Confirmatory factor analysis showed that the goodness-of-fit indices of the scale were satisfactory (χ2/df ratio:=2.338, comparative fit index=0.949, Tucker Lewis index=0.941, root-mean-square error of approximation=0.064, and standardized root-mean-square residual=0.052).

Conclusions

The results show that the scale has good reliability and structural validity; hence, it could be considered an effective instrument. This is the first instrument developed for this purpose.
News Media Framing of Suicide Circumstances and Gender: Mixed Methods Analysis (Preprint)
Authors: Foriest Jasmine C , Mittal Shravika , Kim Eugenia , Carmichael Andrea , Lennon Natalie , Sumner Steven A , De Choudhury Munmun
Published: September 2023

BACKGROUND

Suicide is a leading cause of death worldwide. Journalistic reporting guidelines were created to curb the impact of unsafe reporting; however, how suicide is framed in news reports may differ by important characteristics such as the circumstances and the decedent’s gender.

OBJECTIVE

This study aimed to examine the degree to which news media reports of suicides are framed using stigmatized or glorified language and differences in such framing by gender and circumstance of suicide.

METHODS

We analyzed 200 news articles regarding suicides and applied the validated Stigma of Suicide Scale to identify stigmatized and glorified language. We assessed linguistic similarity with 2 widely used metrics, cosine similarity and mutual information scores, using a machine learning–based large language model.

RESULTS

News reports of male suicides were framed more similarly to stigmatizing (P<.001) and glorifying (P=.005) language than reports of female suicides. Considering the circumstances of suicide, mutual information scores indicated that differences in the use of stigmatizing or glorifying language by gender were most pronounced for articles attributing legal (0.155), relationship (0.268), or mental health problems (0.251) as the cause.

CONCLUSIONS

Linguistic differences, by gender, in stigmatizing or glorifying language when reporting suicide may exacerbate suicide disparities.
Mental health and risk of mortality and hospitalization in COVID-19 patients. Results from the PRECOVID Study in Spain (Preprint)
Authors: Gimeno-Miguel Antonio , Moreno-Juste Aida , Poblador-Plou Beatriz , Ortega-Larrodé Cristina , Laguna-Berna Clara , González-Rubio Francisca , Aza-Pascual-Salcedo Mercedes , Bliek-Bueno Kevin , Padilla María , de-la-Cámara Concepción , Prados-Torres Alexandra , Gimeno-Feliú Luis A
Published: September 2023

BACKGROUND

The COVID-19 pandemic has created unprecedented challenges for health care systems globally. The identification of risk factors is crucial when optimizing medical resources for specific vulnerable population groups such as patients with mental disorders, who are specially at risk of poor COVID-19 outcomes.

OBJECTIVE

We aimed at evaluating the associated risk of hospitalization and mortality in infected individuals based on the presence of specific mental disorders.

METHODS

Retrospective cohort study including all individuals with confirmed infection by SARS-CoV-2 from the PRECOVID Study (Aragon, Spain). Mental health illness was defined as the presence of schizophrenia and other psychotic disorders, anxiety, cognitive disorders, depression and mood disorders, substance abuse, and personality and eating disorders. Multivariable logistic regression models were used to examine the likelihood of 30-day all-cause mortality and COVID-19 related hospitalization based on baseline demographic and clinical variables, including the presence of specific mental conditions, by gender.

RESULTS

In this cohort study including 144,957 individuals with confirmed COVID-19 from the PRECOVID Study (Aragon, Spain), anxiety was the most frequent diagnosis. However, some differences were observed by sex: substance abuse, personality disorders and schizophrenia were more frequently diagnosed in men, while eating disorders, depression and mood, anxiety and cognitive disorders were more common among women. Of the total number of patients with mental illness and COVID-19 infection, 4.7% died and 13.8% were hospitalized during the follow-up period. The presence of mental illness, specifically schizophrenia spectrum and cognitive disorders in men, and depression and mood disorders, substance abuse, anxiety and cognitive and personality disorders in women, increased the risk of mortality or hospitalization after COVID-19, in addition to other well-known risk factors such as age, morbidity and treatment burden.

CONCLUSIONS

Identifying vulnerable patient profiles at risk of serious outcomes after COVID-19 based on their mental health status will be crucial to improve their access to the healthcare system and implement targeted public health prevention measures.
The Real World Impact of App-Based Mindfulness on Perceived Stress: An Observational Study of Headspace Members (Preprint)
Authors: Callahan Christine , Kimber Justin , Hu Emily , Tanner Leah , Kunkle Sarah
Published: September 2023

BACKGROUND

Higher perceived stress is associated with negative mental health outcomes such as depression and anxiety. Digital mental health (DMH) interventions are efficacious tools to address negative mental health outcomes and have helped reduce psychological symptom severity such as anxiety and depression compared to waitlist controls. Although DMH tools have been studied in controlled settings, less is known about the real world evidence of such interventions.

OBJECTIVE

Evaluate changes in perceived stress among Headspace members and the relationship between real world engagement and perceived stress.

METHODS

We evaluated two timepoints of real world perceived stress and engagement data from Headspace app members with baseline moderate and severe perceived stress. Perceived stress was measured using the Perceived Stress Scale (PSS-10) and engagement using active days and active minutes engaged with Headspace as well as number of user sessions. Descriptive statistics were computed for all variables. Correlations examined relationships between PSS-10 baseline and follow-up scores, PSS-10 percent change, days between PSS-10, active days, active days/week, active minutes, active minutes/day, sessions, and sessions/week. T-tests investigated the differences in baseline PSS-10, follow-up PSS-10, PSS-10 percent change, active days, active days/week, active minutes, active minutes/day, sessions, and sessions/week between: 1) those who did and did not improve PSS-10 scores (yes vs. no improvement); and 2) those who improved ≥30% vs. those with <30% improvement.

RESULTS

Overall 21,088 Headspace members were included as participants in these analyses. On average, participants saw a 23.52% decrease in PSS-10 scores from baseline to follow-up. On average participants had 2.42±1.76 active days/week, 25.89±33.40 active minutes/day, and completed 7.11±8.34 sessions/week. T-tests suggest that participants who improved PSS-10 scores from baseline to follow-up had significantly higher baseline PSS-10 scores, more active days, more active days/week, more sessions, and more sessions/week than those who did not improve PSS-10 scores. Additional t-tests suggest that participants with ≥30% PSS-10 improvement had significantly higher baseline PSS-10 scores, more active days, more active days/week, more active minutes, more sessions, and more sessions/week than those with >30% PSS-10 improvement.

CONCLUSIONS

Findings suggest that real world use of Headspace is associated with decreased perceived stress. Furthermore, data suggest that more engagement, specifically weekly active days and sessions, is associated with greater likelihood of stress reduction.
DIFFICULTIES IN ESTABLISHING STABLE AND LONG-TERM LANGUAGE INTEGRATION AMONG FOREIGN STUDENTSIN THE COURSE OF MASTERING HE STATUS CATEGORY
Authors: Nekipelova I. M. , Nekipelov E. Sh.
Published: September 2023

The article is devoted to the research of those encountered among foreign students who study Russian language as a foreign language in mastering one of the most difficult categories of the Russian language - statives. Originally these difficultis are supposed consequences of the objective causes of occurrence are also assumed to be conjugated with the full sensual, resulting from their objective, that is, secondary. In the process of the reserching it needs to show revealed that among the main objective reasons - insufficient exercise of statives from a scientific point of view, the insufficient representation of this category in textbooks and teaching benefits, external and internal grammatical heterogeneity of the statives, the lack of a formulation of the statives in other languages, its variability and possibility of interchangeability another constructions. These reasons it is a part of which are removable, are primary and do not develop from students. The study also showed that the internalization of the verbal statives is complicated by pronounced obvious signs, among which one can single out the rejection of the tendency to predicate speech, the insufficiency of using them in speech, the lack of understanding of the words of the statives as systemic elements of the Russian language, and immunity to their understanding in the oral speech of the Russian language. language. All this makes internalization unstable and short-term. At the end of the study, it was concluded that the desire to study the statives and reduce its use to a minimum is impossible, since it occupies a fairly large space in the Russian language and actively uses Russian speakers in various communicative uses. In this regard, there is scientific research of the nature of words, the formation of a state that gives a methodological description of the characteristics and characteristics of their functions in Russian, as well as the need to compile a list of words, ways to be predicative, explore productive models that implement the properties of the statives in the grammatical plane, description of the possible grammatical environment of predicatives.
REPORTED SPEECH IN RUSSIAN AND ENGLISH AND ITS PRESENTATION USING INFORMATION TECHNOLOGY
Authors: Bokova I. A.
Published: September 2023

The article presents a discription of ways of expressing reported speech in Russian and English, its features, similarities and differences and presentation of this material with the help of computer methods and tools, used in modern didactic process. The study describes educational platforms Stepik and Google Classroom, their common characteristics, features of use and creating online courses. The relevance of this work is related to the necessity for practical application of information technologies, used in creation of electronic educational resources, to the necessity for integrating special tools into the learning process to solve linguistic problems. Due to the constant interest to the questions of comparative analysis of Russian and English grammar, the article presents linguistic material on the basis of which identical courses on platforms Stepik and Google Classroom were created. The result of the Web-systems using aimed at development of online courses is the comparison. In the course of the work, it was revealed that the differences between platforms Stepik and Google Classroom are in using different methods of courses creation and orientation on different target audiences. The article concludes that learning such features of reported speech as connecting parts of a complex sentence using different parts of speech or the sequence of tenses is being simplified by application of information technologies in didactic process.