bluuebunny/crossref_metadata_2025 huggingface dataset:
Mitogen-Activated Protein Kinase and Nuclear Hormone Receptor Crosstalk in Cancer Immunotherapy
Authors: Burgermeister Elke
Published: September 2023

The three major MAP-kinase (MAPK) pathways, ERK1/2, p38 and JNK/SAPK, are upstream regulators of the nuclear “hormone” receptor superfamily (NHRSF), with a prime example given by the estrogen receptor in breast cancer. These ligand-activated transcription factors exert non-genomic and genomic functions, where they are either post-translationally modified by phosphorylation or directly interact with components of the MAPK pathways, events that govern their transcriptional activity towards target genes involved in cell differentiation, proliferation, metabolism and host immunity. This molecular crosstalk takes place not only in normal epithelial or tumor cells, but also in a plethora of immune cells from the adaptive and innate immune system in the tumor–stroma tissue microenvironment. Thus, the drugability of both the MAPK and the NHRSF pathways suggests potential for intervention therapies, especially for cancer immunotherapy. This review summarizes the existing literature covering the expression and function of NHRSF subclasses in human tumors, both solid and leukemias, and their effects in combination with current clinically approved therapeutics against immune checkpoint molecules (e.g., PD1).
FoxO3 Modulates Circadian Rhythms in Neural Stem Cells
Authors: Draijer Swip , Timmerman Raissa , Pannekeet Jesse , van Harten Alexandra , Farshadi Elham Aida , Kemmer Julius , van Gilst Demy , Chaves Inês , Hoekman Marco F. M.
Published: September 2023

Both FoxO transcription factors and the circadian clock act on the interface of metabolism and cell cycle regulation and are important regulators of cellular stress and stem cell homeostasis. Importantly, FoxO3 preserves the adult neural stem cell population by regulating cell cycle and cellular metabolism and has been shown to regulate circadian rhythms in the liver. However, whether FoxO3 is a regulator of circadian rhythms in neural stem cells remains unknown. Here, we show that loss of FoxO3 disrupts circadian rhythmicity in cultures of neural stem cells, an effect that is mediated via regulation of Clock transcriptional levels. Using Rev-Erbα-VNP as a reporter, we then demonstrate that loss of FoxO3 does not disrupt circadian rhythmicity at the single cell level. A meta-analysis of published data revealed dynamic co-occupancy of multiple circadian clock components within FoxO3 regulatory regions, indicating that FoxO3 is a Clock-controlled gene. Finally, we examined proliferation in the hippocampus of FoxO3-deficient mice and found that loss of FoxO3 delayed the circadian phase of hippocampal proliferation, indicating that FoxO3 regulates correct timing of NSC proliferation. Taken together, our data suggest that FoxO3 is an integral part of circadian regulation of neural stem cell homeostasis.
Attitudes of Patients with Adrenoleukodystrophy towards Sex-Specific Newborn Screening
Authors: Yska Hemmo A. F. , Henneman Lidewij , Barendsen Rinse W. , Engelen Marc , Kemp Stephan
Published: September 2023

Newborn screening (NBS) for X-linked adrenoleukodystrophy (ALD) can identify affected individuals before the onset of life-threatening manifestations. Some countries have decided to only screen boys (sex-specific screening). This study investigates the attitudes of individuals with ALD towards sex-specific NBS for ALD. A questionnaire was sent to all patients in the Dutch ALD cohort. Invitees were asked who they thought should be screened for ALD: only boys, both boys and girls or neither. The motives and background characteristics of respondents were compared between screening preferences. Out of 108 invitees, 66 participants (61%), 38 men and 28 women, participated in this study. The majority (n = 53, 80%) favored screening both newborn boys and girls for ALD, while 20% preferred boys only. None of the respondents felt that newborns should not be screened for ALD. There were no differences in the background characteristics of the respondents between screening preferences. Our study revealed a diverse range of motivations underlying respondents’ screening preferences. This study is one of the first to investigate the attitudes of patients towards sex-specific screening for ALD. The outcomes of this study can offer insights to stakeholders engaged in the implementation of NBS programs. ALD patients are important stakeholders who can provide valuable input in this process.
Spanish Workers’ Judgement of Telecommuting during the COVID-19 Pandemic: A Mixed-Method Evaluation
Authors: de Andrés-Sánchez Jorge , Belzunegui-Eraso Ángel
Published: September 2023

This study explores the drivers of employees’ attitudes towards home teleworking with Tobit regression and fuzzy-set qualitative comparative analysis (fsQCA). Drawing from technology acceptance models, it derives hypotheses regarding variable relationships and telecommuting perceptions. Data were obtained from a survey with 3104 responses conducted by the Spanish Agency “Centro de Investigaciones Sociológicas” in Spring 2021. The results emphasize the pivotal role of the family-life impact in shaping telecommuting perceptions, alongside factors like location, ICT satisfaction, employer support, and job adaptability. The results from fsQCA reveal an asymmetric influence of input factors on the positive and negative evaluations. Positive perceptions are associated with family-life positivity, firm support, strong ICT, and non-provincial residence, while negative attitudes relate to family-life negativity, lack of employer support, and poor connectivity. The main innovation of this paper lies in the combined use of correlational and configurational methods, enriching insights into employee telecommuting perceptions beyond traditional regression analysis.
Effects of Sucrose Feeding on the Quality of Royal Jelly Produced by Honeybee Apis mellifera L.
Authors: Wang Ying , Ma Lanting , Wang Hongfang , Liu Zhenguo , Chi Xuepeng , Xu Baohua
Published: September 2023

Royal jelly (RJ) is a highly nutritious secretion of the honeybees’ hypopharyngeal glands (HPGs). During RJ production, colonies are occasionally subjected to manual interventions, such as sucrose feeding for energy supplementation. This study aimed to assess the impact of sucrose feeding on the composition of RJ. The results indicated that RJ obtained from sucrose-fed colonies exhibited significantly higher levels of fructose, alanine, glycine, tyrosine, valine, and isoleucine compared to the honey-fed group. However, no significant differences were observed in terms of moisture content, crude protein, 10-HDA, glucose, sucrose, minerals, or other amino acids within the RJ samples. Moreover, sucrose feeding did not have a significant effect on midgut sucrase activity, HPGs development, or the expression levels of MRJP1 and MRJP3 in nurse bees. Unsealed stored food samples from sucrose-fed bee colonies demonstrated significantly higher sucrose levels compared to sealed combs and natural honey. Additionally, natural honey exhibited higher moisture and Ca levels, as well as lower levels of Zn and Cu, in comparison to honey collected from bee colonies fed sucrose solutions. Based on these findings, we conclude that sucrose feeding has only a minor impact on the major components of RJ.
Transport and Anaesthesia Consideration for Transcatheter Patent Ductus Arteriosus Closure in Premature Infants
Authors: Aw Tuan Chen , Chan Belinda , Singh Yogen
Published: September 2023

Transcatheter device closure of patent ductus arteriosus (PDA) in preterm infants has been proven to be a feasible and safe technique with promising results when compared to surgical ligation. However, managing transport and anaesthesia in extremely premature infants with haemodynamically significant PDA and limited reserves presents unique challenges. This review article focuses on the key considerations throughout the clinical pathway for the PDA device closure, including referral hospital consultation, patient selection, intra- and inter-hospital transport, and anaesthesia management. The key elements encompass comprehensive patient assessment, meticulous airway management, optimised ventilation strategies, precise thermoregulation, patient-tailored sedation protocols, vigilant haemodynamic monitoring, and safe transport measures throughout the pre-operative, intra-operative, and post-operative phases. A multidisciplinary approach enhances the chances of procedure success, improves patient outcomes, and minimises the risk of complications.
Is There a Future for Minimal Access and Robots in Cardiac Surgery?
Authors: Faerber Gloria , Mukharyamov Murat , Doenst Torsten
Published: September 2023

Minimally invasive techniques in cardiac surgery have found increasing use in recent years. Both patients and physicians often associate smaller incisions with improved outcomes (i.e., less risk, shorter hospital stay, and a faster recovery). Videoscopic and robotic assistance has been introduced, but their routine use requires specialized training and is associated with potentially longer operating times and higher costs. Randomized evidence is scarce and transcatheter treatment alternatives are increasing rapidly. As a result, the concept of minimally invasive cardiac surgery may be viewed with skepticism. In this review, we examine the current status and potential future perspectives of minimally invasive and robotic cardiac surgery.
Reference Values for Birth Weight in Relation to Gestational Age in Poland and Comparison with the Global Percentile Standards
Authors: Genowska Agnieszka , Strukcinskiene Birute , Bochenko-Łuczyńska Joanna , Motkowski Radosław , Jamiołkowski Jacek , Abramowicz Paweł , Konstantynowicz Jerzy
Published: September 2023

Introduction. Percentiles of birth weight by gestational age (GA) are an essential tool for clinical assessment and initiating interventions to reduce health risks. Unfortunately, Poland lacks a reference chart for assessing newborn growth based on the national population. This study aimed to establish a national reference range for birth weight percentiles among newborns from singleton deliveries in Poland. Additionally, we sought to compare these percentile charts with the currently used international standards, INTERGROWTH-21 and WHO. Materials and Methods. All singleton live births (n = 3,745,239) reported in Poland between 2010 and 2019 were analyzed. Using the Lambda Mu Sigma (LMS) method, the Generalized Additive Models for Location Scale, and Shape (GAMLSS) package, smoothed percentile charts (3–97) covering GA from 23 to 42 weeks were constructed. Results. The mean birth weight of boys was 3453 ± 540 g, and this was higher compared with that of girls (3317 ± 509 g). At each gestational age, boys exhibited higher birth weights than girls. The weight range between the 10th and 90th percentiles was 1061 g for boys and 1016 g for girls. Notably, the birth weight of Polish newborns was higher compared to previously published international growth standards. Conclusion. The reference values for birth weight percentiles established in this study for Polish newborns differ from the global standards and are therefore useful for evaluating the growth of newborns within the national population. These findings hold clinical importance in identifying neonates requiring postbirth monitoring.
Concomitant Coronary Artery Disease in Identical Twins: Case Report and Systematic Literature Review
Authors: Kamzolas Odysseas , Papazoglou Andreas , Gemousakakis Eleftherios , Moysidis Dimitrios , Kyriakoulis Kοnstantinos , Brilakis Emmanouil , Milkas Anastasios
Published: September 2023

Coronary artery disease (CAD) is multifactorial and strongly affected by genetic, epigenetic and environmental factors. Several studies have reported development of concomitant CAD in identical twins. We report a case in which a pair of Caucasian male monozygotic twins presented almost concomitantly with acute coronary syndrome (ACS) and had concordant coronary anatomy and identical site of occlusion. We performed a systematic literature review of PubMed, Web Of Science and Scopus databases from inception until 28 February 2023 of case reports/case series reporting the concomitant development of CAD in monozygotic twins. We found 25 eligible case reports with a total of 31 monozygotic twin pairs (including the case from our center) suffering from CAD and presenting (most of them simultaneously) with ACS (mean age of presentation: 45 ± 12 years, males: 81%). Coronary angiograms demonstrated lesion and anatomy concordance in 77% and 79% of the twin pairs, respectively. Screening for disease-related genetic mutations was performed in six twin pairs leading to the identification of five CAD-related genetic polymorphisms. This is the first systematic literature review of studies reporting identical twin pairs suffering from CAD. In summary, there is high concordance of coronary anatomy and clinical presentation between monozygotic twins. Future monozygotic twin studies—unbiased by age effects—can provide insights into CAD heritability being able to disentangle the traditional dyad of genetic and environmental factors and investigate the within-pair epigenetic drift.
Hepatokine Profile in Adolescents with Polycystic Ovary Syndrome: A Case–Control Study
Authors: Giannouli Aikaterini , Stefanaki Charikleia , Kouskoutis Christos , Konidari Marianna , Mani Iliana , Konidari Konstantina , Markantonis Sophia L. , Mantzou Aimilia , Dourakis Spyridon P. , Deligeoroglou Efthymios , Bacopoulou Flora
Published: September 2023

The current guidelines suggest routine screening for non-alcoholic fatty liver disease (NAFLD) in patients with polycystic ovary syndrome (PCOS). Hepatokines seem to be promising surrogate endpoints for the diagnosis and severity of NAFLD. PCOS has its onset in adolescence and its metabolic sequalae begin during the same period. There are scarce data on the hepatokine profile of adolescent PCOS patients. This case–control study examined the serum profile of the hepatokines sex hormone-binding globulin (SHBG), selenoprotein P, fibroblast growth factor 21 (FGF21), and fetuin A in a sample of adolescent PCOS patients, and their association to metabolic and hormonal parameters. The selenoprotein P and SHBG serum concentrations were significantly decreased in PCOS patients vs. the controls (median (IQR), 2.47 (0.40) vs. 2.66 (0.36) μg/mL, p = 0.025; mean ± SD, 41.71 ± 19.41 vs. 54.94 ± 22.12 nmol/L, p = 0.011, respectively), whereas selenoprotein P was significantly and positively associated with testosterone (r = 0.325, p = 0.007) and the free androgen index (r = 0.361, p = 0.002). The SHBG demonstrated multiple significant negative correlations with adverse metabolic parameters. Among the PCOS patients, the FGF21 concentrations were significantly higher in those with NAFLD, whereas a 1 pg/mL increase in the FGF21 concentration increased the odds of NAFLD diagnosis by liver ultrasound by 1%, suggesting FGF21 as a potential biomarker for hepatic disease in females with PCOS in adolescence. Fetuin A was the least differentiated hepatokine between the PCOS patients and controls with the least associations with metabolic and hormonal parameters.
External Validation of the IMPROD-MRI Volumetric Model to Predict the Utility of Systematic Biopsies at the Time of Targeted Biopsy
Authors: Ninivaggi Antonella , Guzzi Francesco , Degennaro Alessio , Ricapito Anna , Bettocchi Carlo , Busetto Gian Maria , Sanguedolce Francesca , Milillo Paola , Selvaggio Oscar , Cormio Luigi , Carrieri Giuseppe , Falagario Ugo Giovanni
Published: September 2023

Background: The aim of this study was to validate externally a nomogram that relies on MRI volumetric parameters and clinical data to determine the need for a standard biopsy in addition to a target biopsy for men with suspicious prostate MRI findings. Methods: We conducted a retrospective analysis of a prospectively maintained database of 469 biopsy-naïve men who underwent prostate biopsies. These biopsies were guided by pre-biopsy multiparametric Magnetic Resonance Imaging (mpMRI) and were performed at two different institutions. We included men with a PIRADSsv 2.1 score from 3 to 5. Each patient underwent both an MRI–ultrasound fusion biopsy of identified MRI-suspicious lesions and a systematic biopsy according to our protocol. The lesion volume percentage was determined as the proportion of cancer volume on MRI relative to the entire prostate volume. The study’s outcomes were iPCa (Gleason Grade Group 1) and csPCa (Gleason Grade Group > 1). We evaluated the model’s performance using AUC decision curve analyses and a systematic analysis of model-derived probability cut-offs in terms of the potential to avoid diagnosing iPCa and to accurately diagnose csPCa. Results: The nomogram includes age, PSA value, prostate volume, PIRADSsv 2.1 score, percentage of MRI-suspicious lesion volume, and lesion location. AUC was determined to be 0.73. By using various nomogram cut-off thresholds (ranging from 5% to 30%), it was observed that 19% to 58% of men could potentially avoid undergoing standard biopsies. In this scenario, the model might miss 0% to 10% of diagnosis of csPCa and could prevent identifying 6% to 31% of iPCa cases. These results are in line with findings from the multi-institutional external validation study based on the IMPROD trial (n = 122) and the MULTI-IMPROD trial (n = 262). According to DCA, the use of this nomogram led to an increased overall net clinical benefit when the threshold probability exceeded 10%. Conclusions: This study supports the potential value of a model relying on MRI volumetric measurements for selecting individuals with clinical suspicion of prostate cancer who would benefit from undergoing a standard biopsy in addition to a targeted biopsy.
Moving from Laparoscopic Synthetic Mesh to Robotic Biological Mesh for Ventral Rectopexy: Results from a Case Series
Authors: Drissi Farouk , Rogier-Mouzelas Fabien , Fernandez Arias Sebastian , Podevin Juliette , Meurette Guillaume
Published: September 2023

Introduction: Laparoscopic ventral mesh rectopexy (VMR) is the standard procedure for the treatment of posterior pelvic organ prolapse. Despite significant functional improvement and anatomical corrections, severe complications related to mesh augmentation can occur in a few proportions of patients. In order to decrease the number of rare but severe complications, we developed a variant of the conventional VMR without any rectal fixation and using a robotic approach with biological mesh. The aim of this study was to compare the results of laparoscopic ventral rectopexy with synthetic mesh (LVMRS) to those of robotic ventral rectopexy with biological mesh (RVMRB). Methods: Between 2004 and 2021, patients operated on for VMR in our unit were identified and separated into two groups: LVMRS and RVMRB. The surgical technique for both groups consisted of VMR without any rectal fixation, with mesh distally secured on the levator ani muscles. Results: 269 patients with a mean age of 62 years were operated for posterior pelvic floor disorder: rectocele (61.7%) and external rectal prolapse (34.6%). 222 (82.5%) patients received LVMRS (2004–2015), whereas 47 were operated with RVMRB (2015–2021). Both groups slightly differed for combined anterior fixation proportion (LVMRS 39% vs. RVMRB 6.4%, p < 0.001). Despite these differences, the length of stay was shorter in the RVMRB group (2 vs. 3 days, p < 0.001). Postoperative complications were comparable in the two groups (1.8 vs. 4.3%, p = 0.089) and mainly consisted of minor complications. Functional outcomes were favorable and similar in both groups, with an improvement in bulging, obstructed defecation symptoms, and fecal incontinence (NS in subgroup analysis). In the long term, there were no mesh erosions reported. The overall recurrence rate was 11.9%, and was comparable in the two groups (13% LVMRS vs. 8.5, p = 0.43). Conclusions: VMR without rectal fixation is a safe and effective approach in posterior organ prolapse management. RVMRB provides comparable results in terms of recurrence and functional results, with avoidance of unabsorbable material implantation.
One Patient, Three Providers: A Multidisciplinary Approach to Managing Common Neuropsychiatric Cases
Authors: Özge Aynur , Domaç Füsun Mayda , Tekin Nil , Sünbül Esra Aydın , Öksüz Nevra , Atalar Arife Çimen , Çallı Sümeyye Yasemin , Fidan Yağmur Sever , Evlice Ahmet , Beştepe Engin Emrem , İzci Filiz , Küsbeci Özge Yılmaz , Demirel Esra Acıman , Velioğlu Sibel K. , Ungan Mehmet
Published: September 2023

Background: Neuropsychiatric cases require a multidisciplinary approach for effective management. This paper presented case-based discussions on migraine, dementia, epilepsy, mood disorders, neuralgia, and psychosis from the perspectives of a family physician, neurologist, and psychiatrist. The goal was to highlight the importance of collaboration between healthcare providers in managing these complex cases. Methods: The paper was based on the proceedings of the Mediterranean Neuropsychiatry Symposium, where experts from family medicine, neurology, and psychiatry came together for comprehensive case-based discussions. The CARE framework (Case Report, Appraisal, Research, and Education) was developed to guide reporting and evaluation of case reports in clinical practice. Results: Six cases were presented and discussed, highlighting the importance of a multidisciplinary approach in managing neuropsychiatric cases. The cases included chronic migraine with medication overuse, memory dysfunction with language and behavioral problems, refractory epileptic seizures with subjective sensory symptoms, bipolar affective disorder with normal pressure hydrocephalus, postherpetic neuralgia in a case with bipolar affective disorder, and psychosis with recurrent attacks with the abuse of several substances. Conclusion: A biopsychosocial multidisciplinary approach is essential for managing neuropsychiatric cases effectively on behalf of the patients and public health of the country. The CARE framework can guide the reporting and evaluation of case reports in clinical practice, ensuring that patients receive comprehensive and effective care. Healthcare providers should collaborate to provide the best possible care for patients with complex and multifaceted needs.
Paracolic Gutter Routing: A Novel Retroperitoneal Extra-Anatomical Repair for Infected Aorto-Iliac Axis
Authors: El Beyrouti Hazem , Omar Mohamed , Calimanescu Cristi-Teodor , Treede Hendrik , Halloum Nancy
Published: September 2023

Objective: We describe and analyze outcomes of a novel extra-anatomical paracolic gutter routing technique for surgical repair of aorto-iliac infections. Methods: A double-center, observational, cohort study of all consecutive patients with aorto-iliac infections treated using extra-anatomical paracolic gutter technique. Between May 2015 and December 2022, six patients with aorto-iliac infections were treated with the paracolic gutter routing technique. Cases were identified retrospectively in an institutional database, and data were retrieved from surgical records, imaging studies, and follow-up records. Results: Aorto-bifemoral vascular reconstructions were performed using this technique in six patients. During mean follow-up of 52 ± 44 months, there was one case of graft thrombosis (17%) with subsequent successful thrombectomy. Primary and secondary graft patency rates were 83% and 100%, respectively. There was one mortality (17%) due to candida sepsis. All graft prostheses were patent at last follow-up. Conclusions: The paracolic gutter technique is a useful technique in patients with extensive aorto-iliac infections, arteriovenous and iliac-ureteric fistulas, or at a high risk of vascular graft infection and is associated with favorable reinfection and patency rates.
Business Email Compromise (BEC) Attacks: Threats, Vulnerabilities and Countermeasures—A Perspective on the Greek Landscape
Authors: Papathanasiou Anastasios , Liontos George , Liagkou Vasiliki , Glavas Euripidis
Published: September 2023

Business Email Compromise (BEC) attacks have emerged as serious threats to organizations in recent years, exploiting social engineering and malware to dupe victims into divulging confidential information and executing fraudulent transactions. This paper provides a comprehensive review of BEC attacks, including their principles, techniques, and impacts on enterprises. In light of the rising tide of BEC attacks globally and their significant financial impact on business, it is crucial to understand their modus operandi and adopt proactive measures to protect sensitive information and prevent financial losses. This study offers valuable recommendations and insights for organizations seeking to enhance their cybersecurity posture and mitigate the risks associated with BEC attacks. Moreover, we analyze the Greek landscape of cyberattacks, focusing on the existing regulatory framework and the measures taken to prevent and respond to cybercrime in accordance with the NIS Directives of the EU. By examining the Greek landscape, we gain insights into the effectiveness of countermeasures in this region, as well as the challenges and opportunities for improving cybersecurity practices.
Towards Developing Big Data Analytics for Machining Decision-Making
Authors: Ghosh Angkush Kumar , Fattahi Saman , Ura Sharifu
Published: September 2023

This paper presents a systematic approach to developing big data analytics for manufacturing process-relevant decision-making activities from the perspective of smart manufacturing. The proposed analytics consist of five integrated system components: (1) Data Preparation System, (2) Data Exploration System, (3) Data Visualization System, (4) Data Analysis System, and (5) Knowledge Extraction System. The functional requirements of the integrated system components are elucidated. In addition, JAVA™- and spreadsheet-based systems are developed to realize the proposed system components. Finally, the efficacy of the analytics is demonstrated using a case study where the goal is to determine the optimal material removal conditions of a dry Electrical Discharge Machining operation. The analytics identified the variables (among voltage, current, pulse-off time, gas pressure, and rotational speed) that effectively maximize the material removal rate. It also identified the variables that do not contribute to the optimization process. The analytics also quantified the underlying uncertainty. In summary, the proposed approach results in transparent, big-data-inequality-free, and less resource-dependent data analytics, which is desirable for small and medium enterprises—the actual sites where machining is carried out.
Application of VR Technology for Maritime Firefighting and Evacuation Training—A Review
Authors: Vukelic Goran , Ogrizovic Dario , Bernecic Dean , Glujic Darko , Vizentin Goran
Published: September 2023

Firefighting and evacuation training are important tasks in maritime education and training, especially for crews working on large passenger ships, to ensure the safety of the vessel, cargo and passengers. With the evolution of virtual reality (VR) technology and the introduction of wearable hardware, a change in paradigm has happened in firefighting and evacuation training where these new technologies are being introduced. This paper serves as a review on the use of VR technology in maritime firefighting and evacuation training, trying to answer the following questions: what is the current state of using VR technology, and what are the research gaps that need to be addressed to further accelerate the implementation of VR? Research shows that other industries have adopted the use of VR technology relatively quickly, but the maritime industry still seems reluctant. As for the research gaps, the physics-based modelling of fire spread is discussed along with two other topics: the lack of immersive solutions for evacuation and the potential for developing search and rescue scenarios onboard a ship.
Simulation Framework to Determine Suitable Innovations for Volatility Persistence Estimation: The GARCH Approach
Authors: Samuel Richard T. A. , Chimedza Charles , Sigauke Caston
Published: September 2023

This study rolls out a robust framework relevant for simulation studies through the Generalised Autoregressive Conditional Heteroscedasticity (GARCH) model using the rugarch package. The package is thoroughly investigated, and novel findings are identified for improved and effective simulations. The focus of the study is to provide necessary simulation steps to determine appropriate distributions of innovations relevant for estimating the persistence of volatility. The simulation steps involve “background (optional), defining the aim, research questions, method of implementation, and summarised conclusion”. The method of implementation is a workflow that includes writing the code, setting the seed, setting the true parameters a priori, data generation process and performance assessment through meta-statistics. These novel, easy-to-understand steps are demonstrated on financial returns using illustrative Monte Carlo simulation with empirical verification. Among the findings, the study shows that regardless of the arrangement of the seed values, the efficiency and consistency of an estimator generally remain the same as the sample size increases. The study also derived a new and flexible true-parameter-recovery measure which can be used by researchers to determine the level of recovery of the true parameter by the MCS estimator. It is anticipated that the outcomes of this study will be broadly applicable in finance, with intuitive appeal in other areas, for volatility modelling.
Spatiotemporal Evolution and Mechanisms of Polder Land Use in the “Water-Polder-Village” System: A Case Study of Gaochun District in Nanjing, China
Authors: Zhou Wenzhu , Zhang Yiwen , Tang Yajun
Published: September 2023

This study tries to gain an understanding of the unique spatial patterns of polder areas. Starting from a typical “water-polder-village” combination of spatial elements, our study begins by identifying land use in the polder area using Sentinel-2 data and unsupervised machine learning techniques, taking Gaochun District, Nanjing (China), as an example. Next, we conducted a spatial analysis of change for different years using multiple land-use change indices. Finally, geographically weighted regression (GWR) was developed to account for the heterogeneity of spatial patterns and visualize the spatial distributions of the estimated coefficients. The results, derived from the indices we have constructed, indicate that the water-polder-village is the main subject of spatial pattern changes, with spatial replacement of water and polder and incremental quantitative changes in village areas. Additionally, the main source of existing village land comes from the occupation of polders. Furthermore, the impacts of natural and ecological, development and construction, population, and economic factors on the spatial patterns of the polder area exhibit spatiotemporal heterogeneity. Meanwhile, in rapidly developing areas, population, economy, and construction development may negatively impact the protection of polders. The results provide a reference for the construction and protection of production, living, and ecological spaces in polder areas.
Multiresource Pastoralism, Dynamic Foodways, and Ancient Statecraft in Mongolia
Authors: Honeychurch William , Amartuvshin Chunag , Wright Joshua , Carolus Christina , Hrivnyak Michelle
Published: September 2023

Pastoral nomadic regional confederations, states, and empires have assumed a prominent place in the histories of the Eurasian steppe zone; however, anthropological theory devoted to understanding these political systems is still debated and relatively inchoate. A major question concerns the techniques of political integration that might have brought together dispersed mobile herders under the aegis of these complex, large-scale steppe polities. The first such polity in East Asia, the Xiongnu state (c. 250 BC–150 AD) of Mongolia, has been characterized as a polity built by mobile herders, but in fact the steppe populations of this period followed quite diverse lifeways. Most notably, the establishment of more permanent settlements for craft and agricultural production has complicated the typical narrative of the pastoral nomadic eastern steppe. This study considers ways to conceptualize these interesting variations in lifeway during the Xiongnu period and raises the question of how they might have promoted a novel Xiongnu political order. We analyze transformations within the Egiin Gol valley of northern Mongolia to better understand the organizational, productive, and settlement dynamics and present the first regional landscape perspective on the local transformations incurred by the creation of a Xiongnu agricultural hub. To understand these radical changes with respect to the long-term pastoral nomadic and hunting-gathering traditions of the valley’s inhabitants, Salzman’s flexibility-based model of multiresource pastoralism is of great use. Egiin Gol valley transformations indeed attest to a scale of political economy far beyond the bounds of this local area and suggest an innovative role for indigenous farming in Eurasian steppe polity building.
Bibliometric Analysis of Land Degradation Studies in Drylands Using Remote Sensing Data: A 40-Year Review
Authors: Costa Diêgo P. , Herrmann Stefanie M. , Vasconcelos Rodrigo N. , Duverger Soltan Galano , Franca Rocha Washinton J. S. , Cambuí Elaine C. B. , Lobão Jocimara S. B. , Santos Ellen M. R. , Ferreira-Ferreira Jefferson , Oliveira Mariana , Barbosa Leonardo da Silva , Cunha Lima André T. , Lentini Carlos A. D.
Published: September 2023

Drylands are vast and face threats from climate change and human activities. Traditional reviews cannot capture interdisciplinary knowledge, but bibliometric analysis provides valuable insights. Our study conducted bibliometric research of scientific production on climate change and land degradation in drylands using remote sensing. We examined 1527 Scopus-indexed publications to identify geographic and thematic hotspots, extracting leading authors, journals, and institutions. China leads in publications, followed by the US, Germany, and Australia. The US has the highest citation count. Collaboration networks involve the US, China, and European countries. There has been an exponential increase in remote sensing of land degradation in drylands (RSLDD) publications since 2011. Key journals include “International Journal of Remote Sensing” and “Remote Sensing of Environment”. The analysis highlights the growing interest in the field, driven by Australia, the US, and China. Key areas of study are vegetation dynamics and land use change. Future perspectives for this scientific field involve promoting collaboration and exploring emerging technologies for comprehensive land degradation and desertification research.
Brazil’s Experience with Recognition and Enforcement of Family Agreements in International Child Disputes
Authors: Froeder Dittrich Lalisa
Published: September 2023

Recently, there has been a greater focus on promoting amicable solutions in cross-border family disputes. Alternative dispute resolution methods such as mediation and conciliation have been used in Brazil to avoid lengthy legal proceedings and to resolve cases where concerns about the child’s situation after their return arise. Parties involved in child abduction disputes can feel motivated to reach an agreement when they can decide on child support, custody, and visitation rights before the child’s return. However, enforcing these agreements can be challenging. This article examines Brazil’s experience with international legal cooperation requests under the Convention of 1980 on the Civil Aspects of International Child Abduction (Child Abduction Convention), where the parties faced these issues whilst trying to resolve their conflicts under one or more of the Hague Conventions. The article uses a pragmatic and empirical approach to address difficulties in recognising and enforcing agreements and available alternatives. It concludes with a suggestion for more cooperation between central authorities and with the idea that although adhering to the Convention on Jurisdiction, Applicable Law, Recognition, Enforcement and Cooperation in respect of Parental Responsibility and Measures for the Protection of Children could improve the scenario in Brazil, a new international instrument would significantly enhance the resolution of cross-border disputes, especially for non-European states.
The Endangered Sardinian Grass Snake: Distribution Update, Bioclimatic Niche Modelling, Dorsal Pattern Characterisation, and Literature Review
Authors: Di Nicola Matteo Riccardo , Pozzi Andrea Vittorio , Mezzadri Sergio , Faraone Francesco Paolo , Russo Giorgio , Dorne Jean Lou M. C. , Minuti Gianmarco
Published: September 2023

The Sardinian grass snake, Natrix helvetica cetti, is an endangered endemic snake subspecies with a restricted and highly fragmented geographic distribution. Information on its ecology and detailed geographic distribution are scarce and may negatively impact on its conservation status. Therefore, a literature review on its taxonomy, morphology, ecology, and conservation is presented here. Moreover, field records from the authors, citizen science and the existing literature provide an updated geographic distribution highlighting its presence within 13 new and 7 historic 10 × 10 km cells. Bioclimatic niche modelling was then applied to explore patterns of habitat suitability and phenotypic variation within N. h. cetti. The geographic distribution of the species was found to be positively correlated with altitude and precipitation values, whereas temperature showed a negative correlation. Taken together, these outcomes may explain the snake’s presence, particularly in eastern Sardinia. In addition, analysis of distribution overlap with the competing viperine snake (N. maura) and the urodeles as possible overlooked trophic resources (Speleomantes spp. and Euproctus platycephalus) showed overlaps of 66% and 79%, respectively. Finally, geographical or bioclimatic correlations did not explain phenotypic variation patterns observed in this highly polymorphic taxon. Perspectives on future research to investigate N. h. cetti’s decline and support effective conservation measures are discussed.
Dynamics-Based Calculation of the Friction Power Consumption of a Solid Lubricated Bearing in an Ultra-Low Temperature Environment
Authors: Su Bing , Mao Shuanglong , Zhang Guangtao , Li Han , Cui Yongcun
Published: September 2023

Bearings operating in ultra-low-temperature environments are commonly lubricated with solid lubricants. This study first focused on measuring the traction coefficients of molybdenum disulfide (MoS2) solid lubricant under various working conditions. Based on this data, the friction power consumption of the bearings was calculated and analyzed using a dynamic model. Additionally, experimental verification of the bearing friction power consumption in ultra-low temperature environments was conducted. The research findings will serve as a foundation for the application of solid lubrication bearings in ultra-low-temperature environments.
Investigation of Physicochemical Properties and Surface Morphology of Hydrogel Materials Incorporating Rosehip Extract
Authors: Kędzierska Magdalena , Sala Katarzyna , Bańkosz Magdalena , Wroniak Dominika , Gajda Paweł , Potemski Piotr , Tyliszczak Bożena
Published: September 2023

Hydrogel materials are used in many fields of science and industry. They are of particular importance in biomedical applications. In this work, hydrogels were obtained that could act as a dressing for wounds, at the same time being a carrier of substances with antioxidant activity. The discussed materials were obtained in the field of UV radiation. The correlation between the amount of photoinitiator used and the physicochemical properties and surface morphology of the obtained materials was investigated. In addition, the hydrogels have been incorporated with wild rose extract, which is characterized by antioxidant and anti-inflammatory effects. The analysis of the sorption capacity confirmed that the obtained material is able to absorb significant amounts of incubation fluids, which, in terms of application, will enable the absorption of exudate from the wound. The highest stability of materials was noted for hydrogels obtained with the use of intermediate amounts of photoinitiator, i.e., 50 µL and 70 µL. In the case of using 20 µL or 100 µL, the photopolymerization process did not proceed properly and the obtained material was characterized by a lack of homogeneity and high brittleness. With the increase in the amount of photoinitiator, an increase in the surface roughness of hydrogel materials was confirmed. In turn, spectroscopic analysis ruled out the degradation of materials in incubation fluids, indicating the potential for their use in biomedical applications.
Numerical Study of Step Drill Structure on Machining Damage in Drilling of CFRP/Ti Stacks
Authors: Chen Chen , Zhao Qing , Wang Aixu , Zhang Jing , Qu Qing , Shi Zhanli
Published: September 2023

The tool structure is an important factor affecting the damage of CFRP/Ti stacks machining. However, the impact of tool structure on the formation process of stacks hole damage cannot be fully revealed through experimental methods alone. In contrast, finite element simulation can effectively overcome the limitations of experiments. In this study, a numerical simulation model is established to investigate the relationship between step drill structure and formation process of CFRP/Ti stacks hole damage. Based on this, the research discusses the effect of step drill structure on the burr height of Ti layer, delamination of CFRP, aperture deviation, defects in hole surface. The results show that when the stacking sequence is CFRP to Ti, the burr height of Ti at hole exit decreases first and then increases with the rising of the ratio of primary drill bit diameter to secondary drill bit diameter (kd). When kd is 0.6, the burr height of Ti at hole exit is the lower. As kd increasing from 0.4 to 1.0, delamination factor of CFRP increases by 2.57%, which are affected little by the step drill structure due to the support of Ti. Besides, the aperture size deviation decreases first then increases with the rising of kd, and the minimum aperture size deviation is 2.09 μm when kd is 0.6. In addition, as kd is 0.6, the hole wall defect is fewer. In conclusion, step drill with kd of 0.6 is suitable for drilling of CFRP/Ti stacks.
Post-Earthquake Strengthening of RC Coupling Beams with GFRP Wrapping: Experimental Investigation
Authors: Eser Namık , Töre Erkan , Bal İhsan Engin
Published: September 2023

This research aims to address a post-earthquake urgent strengthening measure to enhance the residual seismic capacity of earthquake-damaged reinforced concrete wall structures with coupling beams. The study consists of a series of tests on half-scale prototype coupling beams with various detailing options, including confined with reduced confinement, partially confined, and unconfined bundles, under cyclic loading conditions. The methodology employed involved subjecting the specimens to displacement-controlled reversal tests, and carefully monitoring their response using strain gauges and potentiometers. The main results obtained reveal that GFRP wrapping significantly enhances the seismic performance of earthquake-damaged coupling beams, even in cases where specimens experienced strength loss and main reinforcement rupture. The strengthened beams exhibit commendable ductility, maintaining high levels of deformation capacity, and satisfying the requirements of relevant seismic design codes. The significance of the study lies in providing valuable insights into the behavior and performance of damaged coupling beams and assessing the effectiveness of GFRP wrapping as a rapid and practical post-earthquake strengthening technique. The findings can be particularly useful for developing urgent post-earthquake strengthening strategies for high-rise buildings with structural walls. The method may be particularly useful for mitigating potential further damage in aftershocks and eventual collapse. In conclusion, this study represents a significant advancement in understanding the post-earthquake behaviors of coupling beams and provides valuable guidance for practitioners in making informed decisions regarding post-earthquake strengthening projects. The findings contribute to the overall safety and resilience of structures in earthquake-prone regions.
The Mechanical Performance of Recycled Slate Waste Fiber Composites Based on Unsaturated Polyester Resins
Authors: Ruiz-Bustos Rocío , López-Uceda Antonio , López-Martínez María , Van Duijn Joost
Published: September 2023

In the last few decades, there has been increasing social awareness for environmental conservation, which is driving the development of composite materials based on natural fibers. These new materials have interesting properties that allow for their use in a variety of applications. This study deals with the development of composite materials based on unsaturated polyester resins reinforced with recycled mineral fibers, such as slate fibers obtained from slate production waste, which have similar properties to glass fiber. The mechanical properties of these composites have been determined by tensile and flexural/bending tests. The influence of various variables such as matrix composition (flexible polyester content) and the weight percentage of fiber added to mechanical properties were evaluated. The flexible/rigid polyester content varied from 0 to 40% and the fiber one from 0 to 30 wt%. Composites with ≥20 wt% of slate fiber reinforcement are shown to have tensile (35 MPa) and flexural (57 MPa) strengths that can compete with materials reinforced with artificial fibers.
Organosilicon Self-Assembled Surface Nanolayers on Zinc—Formation and Their Influence on the Electrochemical and Corrosion Zinc Ongoing
Authors: Petrunin Maxim , Maksaeva Liudmila , Yurasova Tatyana
Published: September 2023

The adsorption of vinyltrimethoxysilane (VS) on the surface of sputtered (by thermal spraying in vacuum) zinc has been investigated. The adsorption isotherms of VC on zinc from an aqueous solution were obtain. In order to determine the adsorption characteristics of VS molecules and to calculate the heats of adsorption, the obtained adsorption isotherms were mathematically processed in terms of the well-known adsorption approaches (approximations, adsorption isotherms). It has been established that this organosilane was chemisorbed on the surface of freshly deposited zinc after 60 min. After the sample was immersed in the solution, a self-organized organosilicon layer was formed on the metal surface. The application of Fourier transform infrared spectroscopy, atomic-force microscopy, and scanning electron microscopy allowed to us study in detail the interactions between VS molecules and the metal surface and to determine the structural features of the formed surface films. The mechanism of formation of self-assembled surface layers on zinc has been proposed. Electrochemical and corrosion research methods have been used to investigate the anticorrosion characteristics of organosilicon films on zinc. High stability of surface organosilicone layers with respect to the corrosive components of electrolyte action was shown by an infrared spectroscopy study carried out after corrosion tests