bluuebunny/crossref_metadata_2025 huggingface dataset:
Application of the Int'l Conv. for the Suppression of the Financing of Terrorism & of the Int'l Conv. on the Elimination of All Forms of Racial Discr. (Ukr. v. Russ.) (Merits) (I.C.J.)
Authors: Marchuk Iryna
Published: October 2024

On January 31, 2024, marking the tenth anniversary of the Russo-Ukrainian war, the International Court of Justice (ICJ) delivered its eagerly anticipated judgment on the merits in Ukraine v. Russia concerning alleged violations of the International Convention for the Suppression of the Financing of Terrorism (ICSFT) and the International Convention on the Elimination of All Forms of Racial Discrimination (CERD). This was the first case lodged by Ukraine against Russia back in 2017, in response to alleged numerous violations arising from Russia's occupation of Crimea and its proxy war in Donbas. Although Ukraine might have hoped for a more favourable outcome, the majority only established narrow and rather minor violations under ICSFT and CERD, despite a plethora of claims advanced by Ukraine under both Conventions. A 13:2 majority found that Russia violated Article 9, paragraph 1 of ICSFT due to its failure to investigate individuals who allegedly committed terrorism financing offences upon receiving the information from Ukraine. As for CERD, another 13:2 majority found that Russia violated Articles 2, paragraph 1(a), and 5(e)(v) of the Convention with regard to the implementation of school education in the Ukrainian language in Crimea. In addition, an 11:4 majority found that Russia violated the provisional measures order, which obliged Russia to lift restrictions on the Mejlis, the highest representative executive organ of Crimean Tatars in Crimea banned by Russian authorities, and imposed the non-aggravation measure. The judges were divided on the scope of the non-aggravation measure, and questioned the appropriateness of establishing the violation of the provisional measures order in part concerning the Mejlis in the absence of the majority's finding of the corresponding violation under CERD on the merits.
Interactions between a toroidal bubble and a free surface
Authors: Bi Yutong , Qin Lang , Yu Liufang , Li Bo , Liu Shuhong , Zuo Zhigang
Published: October 2024

Toroidal bubbles (TBs) represent cases of vortex rings with a gas–liquid interface where a gas vortex ring is encased within a liquid vortex ring, and can serve as effective media for mass conveyance, process mixing, noise reduction and reaction regulation. In this study, we carry out a systematic study on the interaction between a TB and a free surface. According to the high-speed photographic images from the experiments, we identify strong and weak interactions in terms of the normalized maximum free surface deformation

$h_{max}^*$

. Then, we perform numerical simulations based on the volume of fluid (VOF) method in the OpenFOAM platform. Based on both the experimental and the numerical results, we conclude that the Froude number,

$Fr$

, determines the main characteristics during the interaction process. The TB–free surface interaction is essentially the interaction between the liquid vortex ring enveloping the TB and the free surface, supplemented by the TB's complex behaviour. Next, we establish the scaling law of

$h_{max}^*$

based on the energy balance condition. Based on this, we provide the critical

$Fr$

and the slenderness of the TB,

$\eta$

, for identifying the strong and weak interactions, and a parametric plot of the interactions in terms of

$Fr$

and

$\eta$

.
Deepening our perspective about the small and medium pelagic fish: case study in the Canary Islands (NW Africa, Spain)
Authors: Jurado-Ruzafa Alba , Vélez-Belchí Pedro , Sotillo Begoña , Jiménez-Navarro Sebastián , Presas-Navarro Carmen , Martín-Sosa Pablo , Mosquera-Giménez Ángela
Published: October 2024

Small and medium pelagic fish (SMPF, i.e. Scomber colias, Trachurus spp, Sardina pilchardus, and Sardinella spp) in the Canary Islands are mainly targeted by the artisanal purse-seine fleet. The waters in the archipelago (located in the coastal transition zone of the Canary Current Eastern Boundary Upwelling System) are monitored since the late nineties by a hydrographic section (RAPROCAN) designed to study the temporal variability of the eastern subtropical gyre. In this study we analyse the relationship between the SMPF abundance assumed from official sale notes (reported since 2007) and several oceanographic parameters obtained for the outermost water layer (Sea Surface Temperature, SST, and concentration of chlorophyll a, Chla) and from the 200–800 m depth waters (Sea Temperature, ST_200–800, and salinity, Salinity_200–800). Except for SST, statistically significant correlations occur between environmental variables and SMPF landings when one-year time-lag is considered, matching with the time period necessary for these species to attain legal catchable sizes and, hence, being catchable by the fishery. However, in the GLM only Chla resulted a significant explaining variable for the SMPF landings during the following year, probably because this strong correlation overshadows the ST_200–800 influence. Keeping the monitoring systems is crucial to understand, foresee and anticipate potential variations in the fishery resources and to aim the sustainable exploitation of the SMPF populations, even more challenging in the current climate change scenario.
‘Divine deceit’ or the ‘devil's delusion’? Gregory of Nazianzus on Christ's defeat of the devil
Authors: Thomas Gabrielle
Published: October 2024

This essay considers Gregory of Nazianzus’ allusion to ‘divine deceit’, a motif related to the so-called ‘Christus Victor’ theory of atonement. This allusion is curious when we recall that for Gregory, the devil, not God, is the master of deception. When we treat On the Lights (Or. 39) as a literary unit – which commentators have yet to do – we see that Gregory makes several doctrinal affirmations before alluding to what is known as ‘divine deceit’. In this doctrinal discussion, Gregory draws upon the Platonic distinction between the orders of being and becoming as described in the Timaeus. He then alludes to ‘divine deceit’ with respect to the order of ‘becoming’, which bears the possibility of being misapprehended because it is ‘grasped by opinion’. The devil's ‘opinion’ of himself and of Christ, therefore, is suspect. Death – or rather, Christ's vanquishment of it – is the moment of reckoning. Since God alone can defeat death, Christ's putting death to death is the only certain way for the devil to recognise that the ‘Son of Man’ is, after all, the ‘Son of God’. The ‘devil's delusion’, then – not ‘divine deceit’ – best summarises Gregory's understanding of this moment in the history of salvation.
A Source of Confusion: New Archaeological Evidence for the Dorchester Aqueduct
Authors: Manley Harry , Cheetham Paul , Stewart Dave , Russell Miles
Published: October 2024

The Dorchester Aqueduct, located to the north-west of Dorchester (Durnovaria) in Dorset, is arguably the most famous and well-examined Roman watercourse in Britain. The aqueduct has been intermittently investigated over the course of the last 100 years, but most extensively during the 1990s. The upper stretches of the aqueduct and its source have, however, eluded archaeologists, with multiple routes and water sources being suggested. A new programme of geophysical and topographic survey, combined with targeted investigation together with a reappraisal of the excavations from the 1990s, has provided additional evidence for the route of the aqueduct, extending its course for a further two kilometres to Notton on the River Frome.
A novel hybrid information-based PF-WOA algorithm for gas source localization in 3D space
Authors: Wang Li , Ren Ziyu , Fan Shurui , Zhang Yong
Published: October 2024

In recent years, dangerous gas leakage events occur frequently. Rapid and accurate location of gas leakage sources by mobile robots is the key to avoid the expansion of disasters. In order to solve the problem of discontinuous gas concentration gradient and sparse gas environment in three-dimensional space, particle filter, and whale swarm optimization algorithm are integrated to locate gas source. Firstly, the Z-shape search and comb search are used to locate the plume, and then, the particle filter algorithm is combined with the whale optimization method to guide the particle movement, and the random inertial disturbance term is designed to improve the convergence speed and search accuracy of the algorithm. Experimental results in three-dimensional environment show that the proposed information-driven particle filter whale optimization hybrid algorithm effectively guides the robot in localizing gas source within a certain range, significantly enhancing both the efficiency and accuracy of localization compared to other algorithms.
How Long Does a Memory Last? Bayesian Chronological Modelling and the Temporal Scope of Commemorative Practices at Aeneolithic Monjukli Depe, Turkmenistan
Authors: Heit Ilia
Published: October 2024

In this paper the history of one house and a human burial in the prehistoric settlement of Monjukli Depe, Turkmenistan, serves as a case study for the use of Bayesian chronological modelling to approach the reach of past memories. The method combines relative and absolute chronological data and aims not only at a more precise and robust chronology of past events, but also allows estimations of duration of particular processes. However, chronological models must be constructed with care, since the prior archaeological information significantly affects the output. The comparison of three alternative models for the Aeneolithic settlement of Monjukli Depe shows that prior information in modelling has a considerable impact on duration estimates for periods of the settlement history. The modelling chronology for Monjukli Depe allows the tracing of commemorative practices at a generational scale—the memory of Monjukli Depe House 14 was transmitted over several generations of inhabitants long after the house destruction. It is clear that houses possessed a great value in the social life of the settlement since local building histories were remembered over a long time.
Nutrient intake of young South African adults from the baseline of the African-PREDICT cohort study
Authors: Visser Marina , Jordaan Claudine , Wentzel-Viljoen Edelweiss , Schutte Aletta Elisabeth , Van Zyl Tertia
Published: October 2024

Objective:

This study aimed to describe and compare the nutrient intake of young adults in the African Prospective Study on the Early Detection and Identification of Cardiovascular Disease and Hypertension (African-PREDICT) study according to ethnicity and socio-economic status (SES).

Design:

Cross-sectional analysis of baseline nutrient intakes in the African-PREDICT study.

Setting:

North West Province, South Africa

Participants:

Black and white adults (n 1153), aged 20–30 years, were classified into three SES groups. Dietary data were collected using three multiple-pass 24-h dietary recalls.

Results:

Among all participants, over 70 % failed to meet the estimated energy requirements and the estimated average requirements (EAR) for seventeen of the nineteen reported micronutrients. Across SES groups, more than 50 % of participants consistently did not meet the EAR for Ca, Mg, folate, pantothenic acid and biotin, as well as vitamins A, C, D and E. Participants’ distribution by nutrient pattern tertiles showed high adherence to two patterns: one rich in animal protein and saturated fat, and the other in Mg, potassium, Ca, phosphorus and fibre. This was seen only in white participants and high SES. Black participants and low SES showed higher adherence to a plant protein, B-vitamins, Zn and Fe nutrient pattern.

Conclusions:

The dietary intake of young adults in this study was restricted, with none of the groups meeting nutrient requirements for essential nutrients. Further research is needed to establish a direct link between nutrient patterns and the early detection and identification of CVD and hypertension.
Radiobiological evaluation of hypo-fractionated breast cancer radiotherapy regimens in comparison with conventional approaches
Authors: Arjmand Bahare , Chegeni Nahid , Danyaei Amir , Bagheri Ali , Razzaghi Samira , Rasouli Naser , Karimi Arezoo , Saki-Malehi Amal , Hazbavi Maryam , Mahmoudi Farshid
Published: October 2024

Purpose:

This study compares tumor control probability (TCP) and normal tissue complication probability (NTCP) across different hypo-fractionated (HypoRT) and conventional breast radiotherapy regimens using radiobiological models.

Materials and methods:

Computed tomography data from 30 patients with left breast-conserving surgery were used to evaluate three HypoRT regimens (39 Gy and 41·6 Gy in 13 fractions, and 40 Gy in 15 fractions) and a conventional regimen (50 Gy in 25 fractions). Dose-volume histograms (DVHs) were extracted for radiobiological calculations using Equivalent Uniform Dose (EUD) and Poisson models for TCP, and EUD and LKB (Lyman-Kutcher-Burman) models for NTCP.

Results:

Conventional treatment achieved significantly higher TCP (95%) than all HypoRT regimens (p < 0·001), with no significant differences between HypoRT regimens (p > 0·05. The 39 Gy/13 fraction regimen showed the lowest lung NTCP (p < 0·05). HypoRT regimens had significantly lower NTCP for the lungs and heart compared to the conventional regimen (p < 0·01). TCP and NTCP values from Poisson and LKB models were higher than those from the EUD model (p < 0·01).

Conclusion:

HypoRT regimens reduced NTCP, with the lowest values in the regime of 39 Gy/13 fractions regimen, though the conventional regimen had higher TCP.
Catamorphic Abstractions for Constrained Horn Clause Satisfiability
Authors: DE ANGELIS EMANUELE , FIORAVANTI FABIO , PETTOROSSI ALBERTO , PROIETTI MAURIZIO
Published: October 2024

Catamorphisms are functions that are recursively defined on list and trees and, in general, on algebraic data types (ADTs), and are often used to compute suitable abstractions of programs that manipulate ADTs. Examples of catamorphisms include functions that compute size of lists, orderedness of lists, and height of trees. It is well known that program properties specified through catamorphisms can be proved by showing the satisfiability of suitable sets of constrained Horn clauses (CHCs). We address the problem of checking the satisfiability of those sets of CHCs, and we propose a method for transforming sets of CHCs into equisatisfiable sets where catamorphisms are no longer present. As a consequence, clauses with catamorphisms can be handled without extending the satisfiability algorithms used by existing CHC solvers. Through an experimental evaluation on a nontrivial benchmark consisting of many list and tree processing algorithms expressed as sets of CHCs, we show that our technique is indeed effective and significantly enhances the performance of state-of-the-art CHC solvers.
Disinfecting the Dead, Sanitizing Empire: The Cultural Memory of Fallen Soldiers in Cuba
Authors: Bontrager Shannon
Published: October 2024

The misremembering by Americans of the Spanish-Cuban-American War was not an accident of either time or place. Rather, it was a collaboration between the citizenry, political and business elites, and the military-industrial complex centered on the cult of the fallen soldier. As businessmen carved up the Cuban landscape and the military occupied Guantanamo Bay, the war dead played one last service of memory. American commemoration of fallen soldiers acted as a shroud to obscure the practices of American imperialism. The recovery of the war dead thus provides an interesting example of how officials wanted Americans to remember the conflict. Most of the fallen died from disease rather than combat. Recovering the war dead thus entailed an elaborate process of sanitizing the “sick” dead and disinfecting the remains of warriors buried in foreign and tropical soil to repatriate them back to the United States. The metaphorical intersected with the medical in presenting dead soldiers from an imperialistic war with “clean and sterile bones” that would neither threaten the health of the general public nor their collective memory. Such a re-presentation would help shape how Americans remember a clean and sterile “Splendid Little War” without acknowledging the mucky details of empire-building.
Blue Gums, Black Bodies, White Supremacy: Narratives of Racial Contagion in the Late Nineteenth Century
Authors: Cox David G.
Published: October 2024

This article explores the sudden spate of stories concerning the so-called “blue gum negro” (the Blue Gum) that circulated in the national press from the late 1880s to the late 1890s. These reports concerned purportedly blue-gummed, Black assailants, whose bite was alleged to be poisonous, and of whom African Americans were supposedly terrified. This article argues that, although these narratives reinforced white notions of Black criminality and credulity, they marked a particular moment of racialization, in which fears of bodily contagion, generated by the recent revolution in germ theory, were harnessed to notions of embodied racial difference, to express and galvanize white anxieties about racial impurity. Because Blue Gums embodied dysgenic menace, white journalists and writers were often reluctant to disavow their existence, instead capitalizing on the slippage between figurative and literal language that characterized discourse on race. However, in appropriating Black culture and presenting a figure from folklore as a racial type, white writers betrayed not only the essentially superstitious character of racial thought but also the interwoven nature of dominant and subjugated cultures in the United States.
Isolation, pathogenicity, and safety evaluation of a pathogen from buffalobur (Solanum rostratum) in China
Authors: Yan Wenfeng , Zheng Wanting , Zheng Yanan
Published: October 2024

Buffalobur (Solanum rostratum Dunal) is an invasive weed in China, and identifying its pathogens is crucial for developing effective biological control measures. In this study, leaf samples from S. rostratum showing typical disease symptoms were collected in Liaoning and Jilin provinces, China. The isolated fungal pathogens were identified based on their morphological characteristics and by using molecular biology techniques. Pathogenicity was assessed by artificially inoculating spore suspensions from the fungal pathogen onto the seeds, isolated leaves, and plants of S. rostratum. The safety of the fungal pathogens for eight other plant species was also evaluated. We then identified the following five fungal pathogens causing disease in S. rostratum in Liaoning and Jilin provinces: Alternaria alternata, Epicoccum sorghinum, Fusarium equiseti, Curvularia hawaiiensis, and Nigrospora oryzae. These fungal pathogens exhibited pathogenicity, with N. oryzae exhibiting the strongest pathogenicity and highest safety. Nigrospora oryzae demonstrated the highest inhibition rate against the radicle germination length of S. rostratum and showed robust pathogenicity toward both isolated leaves and plants. Notably, despite inducing mild reactions in corn (Zea mays L.), grain sorghum [Sorghum bicolor (L.) Moench], rice (Oryza sativa L)., and tomato (Solanum lycopersicum L.), N. oryzae did not have any detrimental effect on the growth of these plants.
A Global Evaluation of Radar‐Derived Digital Elevation Models: SRTM, NASADEM, and GLO‐30
Authors: Simard Marc , Denbina Michael , Marshak Charles , Neumann Maxim
Published: October 2024

This study evaluates global radar‐derived digital elevation models (DEMs), namely the Shuttle Radar Topography Mission (SRTM), NASADEM and GLO‐30 DEMs. We evaluate their accuracy over bare‐earth terrain and characterize elevation biases induced by forests using global Lidar measurements from the Ice, Cloud, and Land Elevation Satellite (ICESat)'s Geoscience Laser Altimeter System (GLAS), the Global Ecosystem Dynamics Investigation (GEDI) and the ICESat‐2 Advanced Topographic Laser Altimeter System (ATLAS) instruments collected on locally flat terrain. Our analysis is based on error statistics calculated for each DEM tile, which are then summarized as global error percentiles, providing a regional characterization of DEM quality. We find NASADEM to be a significant improvement upon the SRTM V3. Over bare ground areas, the mean elevation bias and root mean square error (RMSE) improved from 0.68 to 2.50 m respectively to 0.00 and 1.5 m as compared to ICESat/GLAS. GLO‐30 is more accurate with bare ground elevation bias and RMSE were below 0.05 and 0.55 m. Similar improvements were observed when compared to GEDI and ICESat‐2 measurements. The DEM biases associated with the presence of vegetation vary linearly with canopy height, and more closely follow the percentile of Lidar Relative Height (RH50). Other factors such as canopy density, radar frequency and Lidar technology also contribute to observed elevation biases. This global analysis highlights the potential of various technologies for mapping of Earth's topography, and the need for more advanced remote sensing observations that can resolve vegetation structure and sub‐canopy ground elevation.
Measurement of the Taylor Microscale and the Effective Magnetic Reynolds Number in the Solar Wind With Cluster
Authors: Roberts O. W. , Klein K. G. , Vörös Z. , Nakamura R. , Li X. , Narita Y. , Schmid D. , Bandyopadhyay R. , Matthaeus W. H.
Published: October 2024

We use magnetic field data from the Cluster mission to estimate the value of the Taylor microscale and the effective magnetic Reynolds number in the interplanetary solar wind. Turbulent cascades can be characterized by the spatial scale at which dissipation begins to impact the local energy transfer, estimated by the Taylor microscale, as well as the separation between the injection and dissipation scales, estimated by the effective magnetic Reynolds number. Estimating the Taylor microscale requires measurements of the autocorrelation function at small separations. The Cluster spacecraft have exceptionally sensitive search coil magnetometers with high time resolution, making them ideal for measuring the Taylor microscale. We obtain a value of km; smaller than most previous measurements. We interpret this value as being smaller due to the higher time resolution, enabling the curvature of the autocorrelation function to be measured closer to the origin, giving a more accurate measurement. Combining the Taylor Microscale's computed value with concurrent correlation length measurements, we obtain a value of for the effective magnetic Reynolds number, which compares well to other observations. The four spacecraft of Cluster also allow directions transverse to the flow to be surveyed. The small separations (7 km) of Clusters 3 and 4 show that the Taylor microscale may vary as a function of direction to the mean magnetic field direction. The observed differences are small, requiring more observations to confirm this anisotropy.
ELFIN‐GPS Comparison of Energetic Electron Fluxes: Modeling Low‐Altitude Electron Flux Mapping to the Equatorial Magnetosphere
Authors: Sun Weiqin , Zhang Xiao‐Jia , Artemyev Anton V. , Mourenas Didier , Morley Steven K. , Angelopoulos Vassilis , Kasahara S. , Miyoshi Y. , Matsuoka A. , Mitani T. , Yokota S. , Hori T. , Keika K. , Takashima T. , Teramoto M. , Shinohara I. , Yamamoto K.
Published: October 2024

Near‐equatorial measurements of energetic electron fluxes, in combination with numerical simulation, are widely used for monitoring of the radiation belt dynamics. However, the long orbital periods of near‐equatorial spacecraft constrain the cadence of observations to once per several hours or greater, that is, much longer than the mesoscale injections and rapid local acceleration and losses of energetic electrons of interest. An alternative approach for radiation belt monitoring is to use measurements of low‐altitude spacecraft, which cover, once per hour or faster, the latitudinal range of the entire radiation belt within a few minutes. Such an approach requires, however, a procedure for mapping the flux from low equatorial pitch angles (near the loss cone) as measured at low altitude, to high equatorial pitch angles (far from the loss cone), as necessitated by equatorial flux models. Here we do this using the high energy resolution ELFIN measurements of energetic electrons. Combining those with GPS measurements we develop a model for the electron anisotropy coefficient, , that describes electron flux dependence on equatorial pitch‐angle, , . We then validate this model by comparing its equatorial predictions from ELFIN with in‐situ near‐equatorial measurements from Arase (ERG) in the outer radiation belt.
Simulated Surface‐Column NO2 Connections for Satellite Applications
Authors: Harkey M. , Holloway T.
Published: October 2024

Observations of near‐surface NO2 show a diurnal pattern with midday minima and daily maxima in the morning and evening. These surface cycles are dependent on chemical processing, transport, and emissions. We evaluate these cycles with the United States Environmental Protection Agency (EPA) community multiscale air quality (CMAQ) model data from the EPA Air Quality Time Series (EQUATES) project, compared with ground‐based measurements from the EPA air quality system, two Pandora measurement sites, and satellite data from TROPOMI. We find that the morning vertical column density (VCD) lags surface concentrations by 1 hr on average, where this lag varies with location and day. The peak VCD can also lead the surface maximum concentration, especially in the evening, responding to transport and afternoon compression of the boundary layer. Modeled NO2 VCD is sensitive to column calculation technique. With hourly daytime satellite‐based NO2 observations newly available from the TEMPO instrument, the timing and magnitude of cycles in near‐surface NO2 versus column NO2 will help inform the utilization of hourly satellite data. This work will help inform the timing of surface‐column connections to better interpret new hourly satellite observations for health and air quality applications, including emissions characterization.
Comprehensive Analysis of a Chloride‐Rich Topographic Depression in Terra Sirenum, Mars: A Possible Lost Basin With Astrobiological Significance
Authors: Singh Deepali , Sinha Rishitosh K. , Acharyya Kinsuk
Published: October 2024

The hygroscopic nature of chlorides gives them the potential to provide a harbor for microbes to adapt and survive in extreme conditions, which is pertinent to Mars, given its evolution of climatic conditions. Moreover, observations of secondary hydrous minerals in chloride‐rich regions have opened the case for a diverse geological environment on the Martian surface. Therefore, through comprehensive analysis, we aim to reconstruct the geological evolution of a chloride‐rich basin within Terra Sirenum. We conducted morphological, morphometric, and mineralogical analyses of the basin and its surrounding area to determine its geological evolution, longevity, and environmental conditions during its activity. Subsequently, we carried out a discharge analysis of the surrounding valley networks and determined the water activity using ionic forms of the associated mineralogy. We observed bright‐toned polygonal cracks within the basin as well as its surrounding terrain, suggesting that the basin extended beyond its present boundary. Mineralogical diversity and age dating of the basin and the surrounding area indicated different geochemical environments and cycles of wetting and drying until the late Hesperian. Whereas, sediment transport modeling suggests that the basin was hydrologically active for more than ten thousand years. Our results show a tell‐tale signature of a large sedimentary basin and a large‐scale geological process within the Terra Sirenum. The water activity modeling show that the geochemical composition of the basin was favorable to support the origin of life forms and/or sustain them and suggest promising aspects of the basin for future landing missions.
Paleomagnetic Data Bearing on the Origin of the Supra‐ Subduction Zone Ophiolites in Southeast Anatolia and the Progressive Closure of the Neotethys Ocean in the Eastern Mediterranean
Authors: Cengiz Mualla , Karabulut Savaş , Çabuk Burak Semih , Rajtschan Verena
Published: October 2024

The Late Cretaceous supra‐subduction zone (SSZ) ophiolites in SE Anatolia form two parallel belts: the northern ophiolitic belt, which was emplaced onto the Tauride platform and a second southern belt emplaced on the Arabian platform. There are controversial hypotheses about the geometry and tectonic process of these ophiolites, which are still not well understood. Here, we test three alternative tectonic models for; (a) One single ocean which is defined by the İzmir‐Ankara‐Erzincan Ocean; (b) A southern branch of the Neotethys Ocean; (c) Two separate oceanic basins, which are the Berit Ocean and the South Neotethys Ocean. We present paleomagnetic results from 161 sites focusing on the sheeted dyke complex, cumulate gabbros, extrusive and sedimentary sequences of the Upper Cretaceous ophiolites in the SE Anatolian region. We also sampled the unconformable cover units from Middle Eocene and Miocene sedimentary rocks to distinguish emplacement related tectonic rotations from post‐emplacement tectonic rotations. Our data indicate that the southern ophiolites (Hatay ophiolite, cumulate gabbro + lava) were formed at a paleolatitude of and those of the northern ophiolites (Göksun, İspendere, Guleman ophiolite, cumulate gabbro + lava) were formed at a paleolatitude of . We hypothesize that the northern ophiolites were derived from the Ocean in a NW‐SE directed subduction zone between the Taurides and the Bitlis Pütürge massif, while the southern ophiolites, in contrast, were formed in the South Neotethys Ocean in a NNW‐SSE directed subduction zone farther northeast of the Taurides. Both the ophiolites reached their present position during Late Cretaceous to Middle Miocene, affected by rigid‐block rotations almost in counterclockwise sense.
Mitophagy: insights into its signaling molecules, biological functions, and therapeutic potential in breast cancer
Authors: Chen Cong , Xiang Aizhai , Lin Xia , Guo Jufeng , Liu Jian , Hu Shufang , Rui Tao , Ye Qianwei
Published: October 2024

Mitophagy, a form of selective autophagy that removes damaged or dysfunctional mitochondria, plays a crucial role in maintaining mitochondrial and cellular homeostasis. Recent findings suggest that defective mitophagy is closely associated with various diseases, including breast cancer. Moreover, a better understanding of the multifaceted roles of mitophagy in breast cancer progression is crucial for the treatment of this disease. Here, we will summarize the molecular mechanisms of mitophagy process. In addition, we highlight the expression patterns and roles of mitophagy-related signaling molecules in breast cancer progression and the potential implications of mitophagy for the development of breast cancer, aiming to provide better therapeutic strategies for breast cancer treatment.
MLL oncoprotein levels influence leukemia lineage identities
Authors: Janssens Derek H. , Duran Melodie , Otto Dominik J. , Wu Weifang , Xu Yiling , Kirkey Danielle , Mullighan Charles G. , Yi Joanna S. , Meshinchi Soheil , Sarthy Jay F. , Ahmad Kami , Henikoff Steven
Published: October 2024

Chromosomal translocations involving the mixed-lineage leukemia (MLL) locus generate potent oncogenic fusion proteins (oncoproteins) that disrupt regulation of developmental gene expression. By profiling the oncoprotein-target sites of 36 broadly representative MLL-rearranged leukemia samples, including three samples that underwent a lymphoid-to-myeloid lineage-switching event in response to therapy, we find the genomic enrichment of the oncoprotein is highly variable between samples and subject to dynamic regulation. At high levels of expression, the oncoproteins preferentially activate either an acute lymphoblastic leukemia (ALL) program, enriched for pro-B-cell genes, or an acute myeloid leukemia (AML) program, enriched for hematopoietic-stem-cell genes. The fusion-partner-specific-binding patterns over these gene sets are highly correlated with the prevalence of each mutation in ALL versus AML. In lineage-switching samples the oncoprotein levels are reduced and the oncoproteins preferentially activate granulocyte-monocyte progenitor (GMP) genes. In a sample that lineage switched during treatment with the menin inhibitor revumenib, the oncoprotein and menin are reduced to undetectable levels, but ENL, a transcriptional cofactor of the oncoprotein, persists on numerous oncoprotein-target loci, including genes in the GMP-like lineage-switching program. We propose MLL oncoproteins promote lineage-switching events through dynamic chromatin binding at lineage-specific target genes, and may support resistance to menin inhibitors through similar changes in chromatin occupancy.
Inhibiting EZH2 targets atypical teratoid rhabdoid tumor by triggering viral mimicry via both RNA and DNA sensing pathways
Authors: Feng Shengrui , Marhon Sajid A. , Sokolowski Dustin J. , D’Costa Alister , Soares Fraser , Mehdipour Parinaz , Ishak Charles , Loo Yau Helen , Ettayebi Ilias , Patel Parasvi S. , Chen Raymond , Liu Jiming , Zuzarte Philip C. , Ho King Ching , Ho Ben , Ning Shiyao , Huang Annie , Arrowsmith Cheryl H. , Wilson Michael D. , Simpson Jared T. , De Carvalho Daniel D.
Published: October 2024

Inactivating mutations in SMARCB1 confer an oncogenic dependency on EZH2 in atypical teratoid rhabdoid tumors (ATRTs), but the underlying mechanism has not been fully elucidated. We found that the sensitivity of ATRTs to EZH2 inhibition (EZH2i) is associated with the viral mimicry response. Unlike other epigenetic therapies targeting transcriptional repressors, EZH2i-induced viral mimicry is not triggered by cryptic transcription of endogenous retroelements, but rather mediated by increased expression of genes enriched for intronic inverted-repeat Alu (IR-Alu) elements. Interestingly, interferon-stimulated genes (ISGs) are highly enriched for dsRNA-forming intronic IR-Alu elements, suggesting a feedforward loop whereby these activated ISGs may reinforce dsRNA formation and viral mimicry. EZH2i also upregulates the expression of full-length LINE-1s, leading to genomic instability and cGAS/STING signaling in a process dependent on reverse transcriptase activity. Co-depletion of dsRNA sensing and cytoplasmic DNA sensing completely rescues the viral mimicry response to EZH2i in SMARCB1-deficient tumors.
Lassa virus persistence with high viral titers following experimental infection in its natural reservoir host, Mastomys natalensis
Authors: Hoffmann Chris , Krasemann Susanne , Wurr Stephanie , Hartmann Kristin , Adam Elisa , Bockholt Sabrina , Müller Jonas , Günther Stephan , Oestereich Lisa
Published: October 2024

Lassa virus (LASV) outbreaks in West Africa pose a significant public health threat. We investigated the infection phenotype and transmission (horizontal and vertical) of LASV strain Ba366 in its natural host, Mastomys natalensis. Here we analyze viral RNA levels in body fluids, virus titers in organs and antibody presence in blood. In adults and 2-week-old animals, LASV causes transient infections with subsequent seroconversion. However, mice younger than two weeks exhibit persistent infections lasting up to 16 months despite antibody presence. LASV can be detected in various body fluids, organs, and cell types, primarily in lung, kidney, and gonadal epithelial cells. Despite the systemic virus presence, no pathological alterations in organs are observed. Infected animals efficiently transmit the virus throughout their lives. Our findings underscore the crucial role of persistently infected individuals, particularly infected females and their progeny, in LASV dissemination within the host population.
Boosting spontaneous orientation polarization of polar molecules based on fluoroalkyl and phthalimide units
Authors: Tanaka Masaki
Published: October 2024

Polar organic molecules form spontaneous polarization in vacuum-deposited films by permanent dipole orientations in the films, originating from the molecule’s potential ability to align itself on the film surface during deposition. This study focuses on developing polar molecules that exhibit spontaneous orientation polarization (SOP) and possess a high surface potential. In the proposed molecular design, a hexafluoropropane (6F) unit facilitates spontaneous molecular orientation to align the permanent dipoles, and a phthalimide unit induces strong molecular polarization. Furthermore, the introduction of phthalimides into the molecular backbone raises the glass transition temperature of the molecules, leading to the suppression of molecular mobility on the film surface during film deposition and an improvement in the dipole orientation. The resulting surface potential slope is approximately 280 mV nm−1 without substrate temperature control. Furthermore, this work proposes a method using position isomers as a design strategy to tune the SOP polarity. The substitution position of the strong polar units influences the direction of the total molecular dipoles and affects the SOP polarity of the 6F-based molecules. The proposed molecular designs in this study provide wide tunability of the SOP intensity and polarity, which contributes to highly efficient organic optoelectronic and energy-harvesting devices.
Mutations of PDS5 genes enhance TAD-like domain formation in Arabidopsis thaliana
Authors: Göbel Anna-Maria , Zhou Sida , Wang Zhidan , Tzourtzou Sofia , Himmelbach Axel , Zheng Shiwei , Pradillo Mónica , Liu Chang , Jiang Hua
Published: October 2024

In eukaryotes, topologically associating domains (TADs) organize the genome into functional compartments. While TAD-like structures are common in mammals and many plants, they are challenging to detect in Arabidopsis thaliana. Here, we demonstrate that Arabidopsis PDS5 proteins play a negative role in TAD-like domain formation. Through Hi-C analysis, we show that mutations in PDS5 genes lead to the widespread emergence of enhanced TAD-like domains throughout the Arabidopsis genome, excluding pericentromeric regions. These domains exhibit increased chromatin insulation and enhanced chromatin interactions, without significant changes in gene expression or histone modifications. Our results suggest that PDS5 proteins are key regulators of genome architecture, influencing 3D chromatin organization independently of transcriptional activity. This study provides insights into the unique chromatin structure of Arabidopsis and the broader mechanisms governing plant genome folding.
Simultaneous path weak-measurements in neutron interferometry
Authors: Danner Armin , Masiello Ismaele V. , Dvorak Andreas , Kersten Wenzel , Lemmel Hartmut , Wagner Richard , Hasegawa Yuji
Published: October 2024

The statistical properties of the detection events constituting the interference fringes at the output of an interferometer are well-known. Nevertheless, there is still no unified view of what is happening to a quantum system inside an interferometer. Strong measurements of path operators destroy the interference effect. In weak measurements, an observable is weakly coupled to a pointer system and the resulting weak values quantify the observable by minimally disturbing the system. Previous which-way experiments with weak measurements could extract either the real or imaginary part of a single weak value with each ensemble. Here, we present the simultaneous full complex quantification of two path weak values with a single ensemble in a Mach–Zehnder neutron interferometer. Magnetic fields, oscillating with different frequencies, change the energy state in each interferometer path. The time-dependent phase between the energy states distinctly marks each path. The resulting beating intensity modulation at the interferometer output gives both path weak values. For the present experiment, the weak values’ absolute value and phase directly describe the observed amplitude and phase of the intensity modulation.
Estimation of hydrogen solubility in aqueous solutions using machine learning techniques for hydrogen storage in deep saline aquifers
Authors: Dehghani Mohammad Rasool , Nikravesh Hamed , Aghel Maryam , Kafi Moein , Kazemzadeh Yousef , Ranjbar Ali
Published: October 2024

The porous underground structures have recently attracted researchers’ attention for hydrogen gas storage due to their high storage capacity. One of the challenges in storing hydrogen gas in aqueous solutions is estimating its solubility in water. In this study, after collecting experimental data from previous research and eliminating four outliers, nine machine learning methods were developed to estimate the solubility of hydrogen in water. To optimize the parameters used in model construction, a Bayesian optimization algorithm was employed. By examining error functions and plots, the LSBoost method with R² = 0.9997 and RMSE = 4.18E-03 was identified as the most accurate method. Additionally, artificial neural network, CatBoost, Extra trees, Gaussian process regression, bagged trees, regression trees, support vector machines, and linear regression methods had R² values of 0.9925, 0.9907, 0.9906, 0.9867, 0.9866, 0.9808, 0.9464, and 0.7682 and RMSE values of 2.13E-02, 2.43E-02, 2.44E-02, 2.83E-02, 2.85E-02, 3.40E-02, 5.68E-02, and 1.18E-01, respectively. Subsequently, residual error plots were generated, indicating the accurate performance of the LSBoost model across all ranges. The maximum residual error was − 0.0252, and only 4 data points were estimated with an error greater than ± 0.01. A kernel density estimation (KDE) plot for residual errors showed no specific bias in the models except for the linear regression model. To investigate the impact of temperature, pressure, and salinity parameters on the model outputs, the Pearson correlation coefficients for the LSBoost model were calculated, showing that pressure, temperature, and salinity had values of 0.8188, 0.1008, and − 0.5506, respectively, indicating that pressure had the strongest direct relationship, while salinity had an inverse relationship with hydrogen solubility. Considering the results of this research, the LSBoost method, alongside approaches like state equations, can be applied in real-world scenarios for underground hydrogen storage. The findings of this study can help in a better understanding of hydrogen solubility in aqueous solutions, aiding in the optimization of underground hydrogen storage systems.
Dietary oyster mushroom fermented Vachellia erioloba pods enhance Boschveld chicken meat healthiness without altering its physicochemical quality, growth performance and physiology
Authors: Magagula Melokuhle Q. , Mthana Makiwa S. , Mthiyane Doctor M. N.
Published: October 2024

The high content of fibre and antinutritional phytochemicals limit the utilization of Vachellia erioloba tree pods as nutraceutical feed additive for indigenous chicken diets. The pods can however be solid-state fermented using oyster mushrooms to enhance the nutritional utility of their spent substrate for the nutrition of the native birds. Therefore, this study investigated the effects of dietary incorporation of V. erioloba pods oyster mushroom spent substrate (OMSS) on growth performance, carcass traits, visceral organs, haemato-biochemistry, and meat quality including its fatty acid composition in Boschveld chickens. In a completely randomized design, 250 4-week old mixed gender Boschveld chicks were randomly allotted to 25 pens in which they were offered treatment diets (0, 1.25, 2.5, 5 and 10% OMSS) each with 5 replicates of 10 for 12 weeks and then slaughtered. While there were neither linear nor quadratic effects of diet on overall feed intake (FI) (P > 0.05) and body weight gain (BWG) (P > 0.05), dietary incorporation of OMSS decreased overall feed conversion efficiency (FCE) (quadratic: P < 0.05) particularly in weeks 5 (linear: P < 0.05), 6 (quadratic: P < 0.01) and 11 (quadratic: P < 0.05) with no effects in subsequent weeks (P > 0.05). Also, OMSS induced no effects on all carcass characteristics, visceral organs, haemato-biochemistry and meat physico-chemical quality (P > 0.05) except for the increase in serum albumin (quadratic: P < 0.05) and bilirubin (quadratic: P < 0.05) as well as 24 h post-slaughter meat lightness (linear: P < 0.01), redness (quadratic: P < 0.05), yellowness (linear: P < 0.05), hue angle (quadratic: P < 0.05), and drip loss (quadratic: P < 0.05). Further, the spent substrate decreased meat myristic (linear: P < 0.01), palmitic (linear: P < 0.05), palmitoleic (linear: P < 0.01), and oleic (linear: P < 0.01) acids, as well as its total polyunsaturated fatty acids (PUFAs) (linear: P < 0.05), monounsaturated FAs (MUFAs) (quadratic: P < 0.01), and n-6 PUFAs (linear: P < 0.05). Furthermore, it decreased the meat n-6/n-3 PUFA ratio (quadratic: P < 0.01), with meat from birds fed diets incorporated with 2.5% OMSS eliciting the lowest ratio of 3.63. In contrast, dietary OMSS increased meat stearic (linear: P < 0.001), docosahexaenoic (quadratic: P < 0.01), and tricosanoic (linear: P < 0.001) acid concentrations as well as its total saturated FAs (SFAs) (linear: P < 0.01) and n-3 PUFAs (quadratic: P < 0.01). In conclusion, dietary feeding of V. erioloba pods-derived OMSS enhanced meat nutritional healthiness without majorly altering its physico-chemical quality as well as growth performance, carcass traits, and haemato-biochemistry in Boschveld indigenous chickens. It is recommended for inclusion in indigenous chicken diets at 2.5% level.
Valorisation of apple pomace for the development of high-fibre and polyphenol-rich wheat flour cookies
Authors: Naseem Zahida , Bhat Naseer Ahmad , Mir Sajad Ahmad
Published: October 2024

Apple pomace, abundant in dietary fibre and polyphenols, often goes unutilized, contributing to environmental pollution as it is discarded in open fields of Jammu and Kashmir. This study aimed to develop functional cookies fortified with apple pomace powder (APP), an industrial by-product. Wheat flour-APP formulations (0%, 5%, 10%, and 15%) were assessed. APP addition notably affected color values and functional properties, enhancing water and oil absorption capacities, swelling power, foam capacity and stability. Phenolic content increased significantly (p < 0.05) post-fortification, elevating antioxidant properties. FT-IR spectroscopy identified distinctive chemical components in wheat flour and APP. Sensory evaluation favored cookies with 10% APP, indicating their potential for consumer acceptance. Thus, APP shows promise for producing innovative functional cookies, improving consumer health, utilizing industrial by-products, and reducing waste from apple processing plants, thereby mitigating environmental pollution.