bluuebunny/crossref_metadata_2025 huggingface dataset:
Single-Exosome Profiling Identifies ITGB3+ and ITGAM+ Exosome Subpopulations as Promising Early Diagnostic Biomarkers and Therapeutic Targets for Colorectal Cancer
Authors: Guo Wei , Cai Yanling , Liu Xianming , Ji Yuge , Zhang Cuiyu , Wang Liyan , Liao Wenting , Liu Yuefei , Cui Nan , Xiang Jinsheng , Li Zesong , Wu Di , Li Jingxin
Published: January 2023

Tumor metastasis is a hallmark of colorectal cancer (CRC), in which exosome plays a crucial role with its function in intercellular communication. Plasma exosomes were collected from healthy control (HC) donors, localized primary CRC and liver-metastatic CRC patients. We performed proximity barcoding assay (PBA) for single-exosome analysis, which enabled us to identify the alteration in exosome subpopulations associated with CRC progression. By in vitro and in vivo experiments, the biological impact of these subpopulations on cancer proliferation, migration, invasion, and metastasis was investigated. The potential application of exosomes as diagnostic biomarkers was evaluated in 2 independent validation cohorts by PBA. Twelve distinct exosome subpopulations were determined. We found 2 distinctly abundant subpopulations: one ITGB3-positive and the other ITGAM-positive. The ITGB3-positive cluster is rich in liver-metastatic CRC, compared to both HC group and primary CRC group. On the contrary, ITGAM-positive exosomes show a large-scale increase in plasma of HC group, compared to both primary CRC and metastatic CRC groups. Notably, both discovery cohort and validation cohort verified ITGB3+ exosomes as potential diagnostic biomarker. ITGB3+ exosomes promote proliferation, migration, and invasion capability of CRC. In contrast, ITGAM+ exosomes suppress CRC development. Moreover, we also provide evidence that one of the sources of ITGAM+ exosomes is macrophage. ITGB3+ exosomes and ITGAM+ exosomes are proven 2 potential diagnostic, prognostic, and therapeutic biomarkers for management of CRC.
Trends and Potential of Machine Learning and Deep Learning in Drug Study at Single-Cell Level
Authors: Qi Ren , Zou Quan
Published: January 2023

Cancer treatments always face challenging problems, particularly drug resistance due to tumor cell heterogeneity. The existing datasets include the relationship between gene expression and drug sensitivities; however, the majority are based on tissue-level studies. Study drugs at the single-cell level are perspective to overcome minimal residual disease caused by subclonal resistant cancer cells retained after initial curative therapy. Fortunately, machine learning techniques can help us understand how different types of cells respond to different cancer drugs from the perspective of single-cell gene expression. Good modeling using single-cell data and drug response information will not only improve machine learning for cell–drug outcome prediction but also facilitate the discovery of drugs for specific cancer subgroups and specific cancer treatments. In this paper, we review machine learning and deep learning approaches in drug research. By analyzing the application of these methods on cancer cell lines and single-cell data and comparing the technical gap between single-cell sequencing data analysis and single-cell drug sensitivity analysis, we hope to explore the trends and potential of drug research at the single-cell data level and provide more inspiration for drug research at the single-cell level. We anticipate that this review will stimulate the innovative use of machine learning methods to address new challenges in precision medicine more broadly.
STOCHASTIC MODEL ANALYSIS OF THE IMPACT OF MEDIA CAMPAIGN ON TRANSMISSION OF COVID – 19 EPIDEMIC.
Authors: Bashiru Kehinde Adekunle , Ojurongbe Taiwo Adetola , Olaosebikan Mutiu L , Adeboye Nureni O , Afolabi Habeeb A , Olukotun Ife
Published: January 2023

The COVID - 19 pandemic is currently causing authorities and public health officials more concern. The goal of the project is to convert a deterministic model for COVID-19 transmissions to a stochastic model, and then analyze the results to see how media-driven awareness campaigns have an impact on the disease's spread. The dynamic COVID-19 model was converted to a stochastic model, which was then examined. The model includes the following categories: Susceptible (S), Exposed (E), Infected class (I),  Isolated class ( ), Aware class  and Recovered class (R), as well as the Cumulative density of awareness programs by media denoted by   . With the help of MATLAB, the converted model is then numerically solved using the Eula Maruyama approach, allowing the existence and uniqueness of the model to be examined. The implementation of awareness programs has been found to have a significant positive impact on the spread of COVID-19. As the rate of implementation of these programs rises, the population that is exposed to the virus and those who are infected with it declines, and it has been hypothesized that this will eventually cause COVID-19 to become extinct. According to the report, putting awareness campaigns into place can help stop the COVID-19 epidemic from spreading.
Storytelling and Cultural Tourism of Architectural Change in Mythology: Focusing on Bongjeongsa Temple in Andong
Authors:   Korean Association of Regional Sociology, Moon Jung Pil
Published: January 2023

In this study, the values of storytelling to be applied to a culture tourism program were suggested by interpreting the Confucian ideology of Joseon and architectural changes in the later generations in terms of modern mythologies through Ahndong Bongjeongsa Temple. As the research method, Bongjeongsa Temple was examined from the aspect of Roland Barthes’s modern mythologies and discussed in three viewpoints found in the historical flow. The categories are the Confucian mythologic feature that shows the symbolism of how Bongjeongsa Temple was built through a human phoenix, the modern mythologic feature which dismantles the building to which Confucian supremacy was applied at the point of cultural assets restoration in 1960s, and the inherited mythological feature that the space of Manselu of Bongjeongsa Temple where Confucianism and Buddhism had been exchanged was applied to the construction of Seowons and to the elements of modern architecture later. The mythological values of storytelling culture tourism centered around Bongjeongsa Temple are as follows: First, Bongjeongsa Temple clearly reveals the semiotic meanings of ‘a phoenix’, ‘heavenly lamp’, ‘placenta of a king’ and etc. with its tale of establishment, and the analytic contents of the Buddhist tales implying a unified nation of those times should be reflected as the value of culture tourism storytelling. Second, the symbolized tradition in which a phoenix represents a king in the Bongjeongsa Temple foundation tale and the Confucian myth where Toegye is praised as a human phoenix need to be discussed as culture tourism contents that can be developed into an ideological value after being mixed with Buddhistic beliefs. Third, the dismantlement of ‘Wuhwalu’ and ‘Jinyeomun’ was the act of space restoration eliminating the complexity from the exchange between Buddhism and Confucianism, and needs to be recognized as the storytelling value to reflect on the modern mythological behavior exerted on Bongjeongsa Temple from which the historical trail had been erased. ‘Manselu’ of Bongjeongsa Temple is the space where monks and classical scholars interacted, and ‘Mandaelu’ of Byeongsanseowon, a Confucian building, has the common architectural element. It is the concept of ‘Nuhajinib’, shift of space and an entrance function, and ‘Lu malu’ to which nature was introduced with Chagyeong technique, and has been settled as the value of an inheritance factor of the traditional architectural culture today. Therefore, the archetetural elements related to the foundation tale of Bongjeongsa Temple can create the storytelling value with the implication of liberal arts that tourists can actually recognize with traditional architecture.
Validation of Maumgram Scale for Adolescents
Authors:   Korean Society for  Holistic Convergence Education, Hwang Jae yeon , An Kwan Su
Published: January 2023

This study retests the validity of the preliminary Maumgram scale developed for adolescents. Errors were found from a few of items among seven factor of preliminary Maumgram scale developed by An Gwansu(2021). To correct errors, it aims to retest the reliability and the validity of the scale, by analyzing the factorial structure and the composition of items in it. It examined the sample used for both exploratory and confirmatory factor analysis based on the data of 280 junior high and high school students, collected by a previous study, and tested the concurrent validity, among criteria-related validity, by administering questionnaires to 312 junior high and high school students in Chun-gnam and Jeong-buk. The findings show that the factor structure consists of seven factors (31 items) such as respect for persons, forgiveness, self-control, willpower, autonomy, acceptance and altruism, and the validity of the factor model is acceptable. The concurrent validity was tested to show that the Maumgram scale has significant correlations with the scales of Unconditional self-acceptance, Brief self-control, Psychological well-being, and Tolerance.
SAĞLIĞIN SOSYAL BELİRLEYİCİLERİNDEN SONRA YENİ BİR KONSEPT: SAĞLIĞIN TİCARİ BELİRLEYİCİLERİ
Authors: Yıldırım Öztürk Elif Nur , Uyar Mehmet
Published: January 2023

Bu derlemede sağlığın tanımından ve belirleyicilerinden yola çıkılarak son yıllarda popüler bir terim olmaya başlayan
sağlığın ticari belirleyicilerinin incelenmesi ve değerlendirilmesi amaçlanmıştır. İnsan sağlığını olumlu veya olumsuz
olarak etkileyen özel sektör aktiviteleri sağlığın ticari belirleyicileri olarak adlandırılmaktadır. Sağlığın ticari belirleyicileri
geniş bir yelpazede pek çok sağlık sonucu meydana getirmektedir. Obezite, diyabet, kardiyovasküler hastalıklar,
kanser, trafik kazaları, ruh sağlığı sorunları ve sıtma bu sağlık sonuçlarından bazıları olarak karşımıza çıkmaktadır.
Sağlığın ticari belirleyicileri nispeten yeni bir anlayış ve içeriktir. Bu belirleyicilerin farkında olunması, izlenmesi ve bu
belirleyicilerle mücadele edilmesi önemli görünmektedir. Çok uluslu şirketlerin ve özel sektörün toplum sağlığını nasıl
etkilediğinin belirlenebilmesi ve etkili mücadele stratejileri ortaya konabilmesi için kanıt düzeyi yüksek araştırmalara
ihtiyaç duyulmaktadır.
EPIDEMIOLOGICAL STUDIES ON HIV/AIDS IN TÜRKİYE: A REVIEW
Authors: Yurdakul Şefik , Mehmet Nimetcan
Published: January 2023

Human Immundeficiency Virus (HIV), Acquired Immune Deficiency Syndrom (AIDS) is a major public health problem
continues to affect millions of people all over the world. An average of 79.3 million people died from HIV-related causes
since the start of the epidemic. HIV has many different routes of transmission, and the frequency of transmission and
the most common mode of transmission varies in different parts of the world. In Turkiye, there have been changes in
epidemiological data on HIV over the years. This is a c review paper. The published studies on HIV/AIDS and reportes
in Turkiye were reviewed. The aim of this review is to analyze epidemiologic publications since the first case was seens
in Turkiye on HIV/AIDS and to determine the studies quantity and quality to explore mode of transmission of HIV in the
country. All publications published between 1985 and 2022 were reviwed. 756 studies were identified and 54 original
articles, guidelines, reports and symposium presentation were included. The types of researches, the number of
participants, the participant groups, study location, gender and mode of transmission were examined. HIV/AIDS
prevelance is increasing. The mode of transmission is common through heterosexual transmission and men who have
sex with men transmission mode is increasing. It was seen that there were not enough large-scale studies at the
national level. Further studies on HIV/AIDS should be conducted as national level or multicenter.
Pasarofça Antlaşması’nı Tarafları İçin Zorunlu Kılan Nedenler Üzerine Bir Değerlendirme
Authors: ERCAN Hüseyin Onur
Published: January 2023

Bâbıâlî tarafından Aralık 1714’te Venedik Cumhuriyeti’ne karşı ilân edilerek başlayan ve 1715-1718 yılları arasında fiilen cereyan eden Osmanlı-Venedik-Habsburg Savaşı, Osmanlılara ilk safhada Venedik’e karşı askerî zaferler sağlamışsa da Habsburgların savaşa dâhil olmasıyla Tuna’nın kuzeyinde beklenmedik kayıplar yaşattı. Savoy Prensi Eugen idaresindeki Habsburglar ile 5 Ağustos 1716’da Petervaradin’de karşılaşan Osmanlı ordusu, Serdar-ı Ekrem Ali Paşa’nın şehadetiyle birlikte ağır bir yenilgi aldı. Savaşın devamında Osmanlılar, evvela 164 yıldır hâkimiyetinde bulundurduğu Temeşvar (13 Ekim 1716) ve akabinde Orta Avrupa’nın en önemli askerî üssü konumundaki Belgrad Kalelerini, Habsburglara vire ile teslim etmek durumunda kaldı (18 Ağustos 1717).

Osmanlı-Venedik-Habsburg Savaşı’nı resmen sonlandıran Pasarofça Antlaşması'na (21 Temmuz 1718) giden diplomatik yolu açan Sâbık Belgrad Muhafızı Mustafa Paşa’nın 1717 Eylül’ündeki mektubundan barış akdine kadar geçen yaklaşık on aylık zaman diliminde Osmanlı ve Habsburg saraylarınca oluşturulmuş diplomatik belgeler ele alındığında, her iki tarafın ortak bir paydada buluşmak adına devamlı olarak müdârâ ettiği gözlenmektedir. Bu makale, Pasarofça Antlaşması’nı tarafları için zorunlu kılan nedenler üzerine mukayeseli bir analizi içermektedir.
Peningkatan Motivasi Belajar Siswa Pada Pembelajaran Qur'an Hadis Melalui Metode Numbered Head Together
Authors: Alimin Miftahul , Djuwairiyah Djuwairiyah , Aeni Miftahul
Published: January 2023

Motivasi belajar siswa kelas VII MTs. Al-Islamiyah Bebidas Lombok Timur NTB pada mata pelajaran Al-Qur’an Hadis masih kurang/rendah, karena disebabkan proses pembelajaran kurang menyenangkan dan kurang bervariasinya metode pembelajaran. Oleh sebab itu, metode pembelajaran perlu diperbaiki agar dapat meningkatkan motivasi belajar siswa sehingga hasil belajarnya pun meningkat. Untuk mengatasi permasalahan tersebut diterapkan metode play game numbered head together (NHT) untuk meningkatkan motivasi belajar siswa. Desain penelitian menggunakan Penelitian Tindakan Kelas (PTK). Hasil penelitian dapat disimpulkan bahwa penerapan metode pembelajaran Numbered Head Together (NHT) mampu meningkatkan motivasi belajar siswa pada pelajaran al-qur’an hadist siswa kelas VII MTs. Al-Islamiyah Bebidas Lombok Timur NTB. Hal itu dapat dibuktikan: 1) Adanya peningkatan ketepatan aktivitas guru sesuai prosedur pada siklus I yaitu 78% (cukup), pada siklus II 97% hasinya meningkat (sangat baik) dan 2) Adanya peningkatan motivasi belajar siswa MTs Al-Islamiyah Bebidas disetiap siklusnya yaitu pada pra siklus 35% dengan kriteria kurang, pada siklus I diperoleh prosentase sebanyak 55% dengan kriteria kurang, pada siklus II diperoleh prosentase sebanyak 80% dengan kriteria baik
Od „Sztuki łódzkiej” do „Przyjaznego miasta”. Dobre praktyki czy nowa jakość w zakresie upowszechniania dóbr kultury?
Authors: Rutkowska-Siuda Daria , Pawłowska Aneta , Długosz Paulina
Published: January 2023

Ustawa z dnia 19 lipca 2019 r. o zapewnianiu dostępności osobom ze szczególnymi potrzebami otworzyła nową perspektywę działań nakierowanych na odbiorców o szczególnych potrzebach. Na wybranych działaniach grantowych i projektowych prowadzonych przez zespół naukowców z Uniwersytetu Łódzkiego oraz Muzeum Miasta Łodzi zarysowane zostaną możliwości płynące z dostępności architektonicznej, informacyjno-komunikacyjnej oraz cyfrowej, które stanowią przykłady dobrych praktyk w zakresie upowszechniania dóbr kultury. Zaprezentowane zostaną przedsięwzięcia związane z rewitalizacją i poprawą infrastruktury Muzeum Miasta Łodzi, niwelujące bariery architektoniczne i pozwalające na wprowadzenie nowej przestrzeni ekspozycyjnej z opracowanym do niej systemem informacyjno-komunikacyjny. Artykuł prezentuje zasadnicze koncepcje związane z projektem „Przyjazne miasto” (realizacja w latach 2021–2024), które poprzedzają doświadczenia nabyte przez pracowników UŁ w szeregu badań dotyczących sposobów wspierania osób z niepełnosprawnością wzroku prowadzonych od 2013 r. Niezwykle istotnym obszarem gromadzenia tych doświadczeń były działania podjęte w projekcie „Sztuka łódzka na tle sztuki europejskiej. Wykluczeni/Włączeni”. Rozliczne konsultacje z grupami osób z niepełnosprawnościami sensorycznymi oraz z kuratorami i edukatorami muzealnymi pozwoliły na wypracowanie dobrze odbieranej formy opisu audiodeskrypcyjnego. Opracowane narzędzia dydaktyczne takie jak tyflografiki, książki z pismem brajlowskim i powiększonym czarnodrukiem znacząco wpłynęły na wzrost kompetencji kluczowych odbiorców.
Low temperature selective growth of Ga-doped and Ga–B co-doped germanium source/drain for PMOS devices
Authors: Porret Clement , Rengo Gianluca , Ayyad Mustafa , Hikavyy Andriy , Rosseel Erik , Langer Robert , Loo Roger
Published: January 2023

The peculiarities and physical properties of gallium-doped (Ge:Ga) and gallium and boron co-doped germanium (Ge:Ga:B) epilayers grown at low temperature (320 °C) by chemical vapor deposition, are investigated and benchmarked against their boron-doped (Ge:B) counterpart. Ge:Ga films with resistivities <0.3 mΩ.cm < 0.3 mΩ.cm are demonstrated, outperforming Ge:B prepared with a similar method. A selective Ge:Ga growth process based on a cyclic deposition and etch routine is developed and applied to fin structures. Full process selectivity towards nitride and oxide surfaces is demonstrated. Ga incorporation is, however, reduced compared to non-selective growth, resulting in a degradation of the electrical performance. Ti/Ge:Ga(:B) contacts are finally evaluated, with the aim of providing new solutions for advanced Ge-based devices.
Accurate evaluation of interface trap density at InAs MOS interfaces by using C–V curves at low temperatures
Authors: Yoshizu Ryohei , Sumita Kei , Toprasertpong Kasidit , Takenaka Mitsuru , Takagi Shinichi
Published: January 2023

A method to evaluate the interface trap density (D
it) accurately by using high-frequency C–V curves at InAs MOS interfaces is experimentally examined, where quick responses of the interface traps at room temperature make D
it evaluation based on the high-frequency C–V (Terman) method difficult. Therefore, low-temperature measurements of the C–V curves were performed to suppress the response of the interface traps. We studied the impact of the accuracy of the oxide capacitance C
OX, distribution function, and C–V hysteresis owing to slow traps on the D
it values evaluated by the Terman method. It was found that the accuracy of C
OX and the choice of distribution function had a slight effect on the accuracy of the D
it evaluation. It was also revealed that a measurement temperature lower than 40 K and limited gate voltage ranges in the C–V scan were indispensable for the accurate evaluation of D
it.
Two-step growth of κ-Ga2O3 thin films on 4H-SiC substrates with temperature-varied buffer layers using mist chemical vapor deposition
Authors: Cho Seong-Ho , Shin Yun-Ji , Jeong Seong-Min , Kwon Se-Hun , Bae Si-Young
Published: January 2023

Two-step growth of κ-Ga2O3 thin films on 4H-SiC substrates was attempted with temperature-varied buffer layers via mist chemical vapor deposition. The first-step Ga2O3 buffer layers affect the phase formation and grain size variation depending on growth temperatures. In the second-step thin-film growth, the κ-Ga2O3 thin film was grown at a fixed temperature of 500 °C regardless of various buffer layers. Three zones, namely, amorphous, κ phase, and mixed phase, were categorized in the κ-Ga2O3 thin films according to the buffer growth temperature. High-quality and smooth κ-Ga2O3 thin films could be achieved through the grain growth competition and slight buffer temperature variation in the two-step growth.
Basil Hatim, Jeremy Munday (eds): Translation. An Advanced Resource Book
Authors: Laszlóczki László
Published: January 2023

A Routledge Applied Linguistics átfogó könyvsorozata hallgatók és kutatók tanulmányaihoz nyújt támogatást az angol nyelv és az alkalmazott nyelvészet fő területein. A sorozat minden egyes könyve három fő részen keresztül vezeti végig az olvasót, lehetővé téve számára, hogy felfedezze a tudományág főbb témáit, ezáltal fejlesztve saját magát is. A könyvben a témák újra és újra előke- rülnek, kibővülnek és összefonódnak egymással. Az olvasó megértését izgalmas feladatok és folya- matosan felvetődő kérdések erősítik.
OFFI Akadémia XXIV. Fordítástudományi Konferencia
Authors: Engel Izolda
Published: January 2023

Huszonnégy éves hagyomány új köntösben: idén az Országos Fordító és Fordításhitelesítő Iroda (OFFI) és az ELTE Fordító- és Tolmácsképző Tanszéke (ELTE FTT) külön időpontokban rendezték meg a hagyományos tavaszi fordítástudományi konferenciájukat.
TransELTE 2022 Konferencia
Authors: Karádi Gerda , Robin Edina
Published: January 2023

2022. április 7-én és 8-án az Eötvös Loránd Tudományegyetem Nyelvi Közvetítés Intézetének Fordító- és Tolmácsképző Tanszéke immáron 24. alkalommal rendezte meg a TransELTE fordítástudományi konferenciát.
Penerapan Aspek Pemerintahan Milik Rakyat Dan Pemerintahan Mengacu Pada Pasar Dalam Konsep Reinventing Government Di Dinas Pariwisata Dan Kebudayaan Kabupaten Pangandaran
Authors: Ramadhani Mita Fathari , Pikri Faizal , Wahidah Idah
Published: January 2023

Pada Tahun 2020 Kabupaten Pangandaran berhasil menduduki peringkat pertama sebagai daerah wisata di Jawa Barat di antara kabupaten/kota lainnya yang banyak dikunjungi pengunjung lokal. Kabupaten Pangandaran memiliki penduduk yang dinamis dan kompleks akan tetapi pemanfaatan dan pemberdayaan potensi alam, budaya maupun manusianya kurang optimal. Objek wisata pantai di Kabupaten Pangandaran mendominasi pilihan destinasi wisata sehingga objek wisata lainnya seperti desa wisata, wisata kuliner, cagar alam, dan wisata alam tidak terlalu dikenal oleh publik terutama oleh masyarakat di luar Kabupaten Pangandaran. Padahal, destinasi wisata selain objek wisata pantai di Kabupaten Pangandaran memiliki potensi yang tidak kalah besar. Selain itu para pelaku usaha jasa pariwisata dan media massa yang masih belum cukup optimal untuk membentuk citra kepariwisataan di kabupaten Pangandaran, Dengan demikian penilitian ini bertujuan untuk mengetahui bagaimana penerapan aspek Pemerintahan Milik Rakyat Dan Aspek Pemerintahan Mengacu Pada Pasar Dalam Konsep Reinventing government Di Dinas Pariwisata dan kebudayaan Kabupaten Pangandaran. Metode yang digunakan dalam penelitian ini adalah metode penelitian deskriptif kualitatif, dengan penentuan sampel menggunakan teknik purposive sampling. Hasil dari penelitian ini adalah penerapan aspek pemerintahan milik rakyat dan aspek pemerintahan mengacu pada pasar sudah diterapkan dengan baik namun belum masih optimal karena masih banyak masyarakat yang belum mengetahui program-program yang diadakan oleh pihak Dinas pariwisata dan kebudayaan Kabupaten Pangandaran.
UTERINE SCAR ENDOMETRIOMA: A CASE REPORT
Authors: Masheerul Haq Malik , Bashir Noorulain , Shaheen Sehrish , Rashid Haroon
Published: January 2023

Introduction And Importance: Uterine scar endometriosis is a rare form of endometriosis due to previous surgical
scars from obstetrical and gynecological procedures. Its challenging diagnosis to make. A 34- Case presentation:
year-old multiparous female presented with intermittent lower abdominal pain and inter-menstrual bleeding for the
past 4 months .Ultrasound revealed a heterogenous, predominantly hyperechoic lesion measuring 40x51x54mm in the
myometrium of anterior lower uterine segment extending to cervical stroma. MRI revealed a lobulated mass lesion in the
anterior wall of lower uterine segment, extending along the scar niche. The lesion showed heterogenous hyperintense
signal on T2WI with hyperintense signal on T1WI (sub-acute blood). No significant post contrast enhancement was seen.
Impression of a scar site endometriosis was made. Subsequently the patient underwent diagnostic laparoscopy, which
revealed a lobulated cystic mass in the lower uterine segment, with oozing of chocolate brown material on compression.
As the mass was deep-seated in the lower uterine segment, a laparotomy was decided upon and total abdominal
hysterectomy with varian conservation was performed. Histopathology confirmed the diagnosis of endometriosis.
Conclusion: In any women of reproductive age with lower abdominal pain and solid appearing mass lesion at the uterine
scar from previous obstetric or gynaecologic surgery, uterine scar endometriosis should be considered.
EVALUATING URBAN GREENING SCENARIOS ON URBAN HEAT ISLANDS EFFECTS
Authors: Karimipour Hoda
Published: January 2023

An Urban Heat Islands (UHI) are one of the most common phenomena of the 21st century. Climate change, and the
associated rising trend of urban temperature is exaggerating the creation and extension of urban heat islands (UHI). This
paper investigates various urban greening scenarios in the line with developing the resilient Sydney strategical
document. Two different cooling street strategies are investigated in this research including high reflective pavement
and green canopy cover. ENVI-Met software has been applied for simulating and quantifying microclimate processes at
the urban scale before and after introducing urban greening scenarios. The results of this study show that applying the
light-coloured pavement instead of asphalt surface will decrease surface temperature by up to 20°C. Planting short to
medium height trees in the side walks will decrease the air temperature by up to 3°C and surface temperature by up to
11°C.
Исследование пробиотических свойств бактериального концентрата
Authors: Занданова Туяна Нимбуевна
Published: January 2023

Введение: В современных условиях необходимо поддержание и восстановление микроэкологического статуса человека с помощью пробиотиков. Такие факторы как ухудшение экологии, стрессы, применение консервантов в продуктах питания, заболевания являются причинами развития дисбактериоза. Пробиотические бактерии оказывают многоуровневое воздействие на организм человека: восстановление нормальной микрофлоры кишечника, синтез биологические активных веществ, укрепление кишечного барьера, подавление роста патогенных и условно-патогенных бактерий. Применение поликомпонентных пробиотиков при лечении дисбактериозов обеспечивает комплексное воздействие различных метаболитов на кишечную микробиоту. Многоштаммовые микробные сообщества обладают более высоким адаптационным потенциалом в сравнении с моновидными препаратами. Однако, создание многоштаммовых микробных сообществ требует тщательного подбора по их биосовместимости. Цель: исследовать пробиотические свойства бактериального концентрата микробного консорциума (МК), полученного путем длительной автоселекции микрофлоры кефирной грибковой закваски при низких значениях рН.  Материалы и методы:  Был исследован замороженный бактериальный концентрат микробного консорциума, полученный путем наращивания биомассы на творожной сыворотке с добавлением ростовых компонентов. Для сравнительного анализа использовали исходный инокулят - микробный консорциум.Результаты. В результате автоселекции формируется симбиотическое сообщество микроорганизмов, состоящее из термофильных и мезофильных лактобацилл, дрожжей сбраживающих и не сбраживающих лактозу, ацетобактерий. Полученный МК идентичен по своему составу естественной популяции микроорганизмов курунги и кумыса. Выводы: В статье приведены данные влияния различных факторов, моделирующих условия желудочно-кишечного тракта человека, на выживаемость микрофлоры МК и бактериального концентрата. Представлены данные по адгезивной и антагонистической активности.
Особенности рынка хлебопечения и перспективные направления развития хлебопекарной отрасли Беларуси и России
Authors: Акулич Александр Васильевич , Костюченко Марина Николаевна , Балыхин Михаил Григорьевич , Самуйленко Татьяна Дмитриевна , Шапошников Игорь Иосифович
Published: January 2023

Введение: Современная хлебопекарная промышленность Союзного Государства является одной из ведущих отраслей пищевой промышленности, а по объемам производства в натуральном выражении она занимает одно из первых мест в мире. Ее состояние и перспективы развития обуславливают множество как внутренних, так и внешних факторов. Цель: Целью исследования является выявление закономерностей и особенностей функционирования рынка хлебопечения Российской Федерации и Республики Беларусь в динамике последних десяти лет и установление перспективных направлений его развития в современных реалиях XXI века.

Материалы и методы: Аналитические исследования проведены с использованием данных Росстат и Белстат, Минсельхозпрод Беларуси, КУП «Минскхлебпром», Белкоопсоюз. Результаты: В представленной работе отражена сравнительная характеристика изменений потребления хлебобулочных изделий, их объемов и структуры производства в Республике Беларусь и Российской Федерации за 2010–2020 гг. Рассмотрены основные причины, обуславливающие динамику названных процессов. Уделено внимание проблемам формирования стоимости и розничных цен на хлебобулочные изделия и пути их решения в современных условиях функционирования хлебопекарной отрасли двух стран. Представлены совместные достижения научных организаций, учреждений высшего образования и предприятий хлебопекарной отрасли в области технологий хлебобулочных изделий в дискретном режиме, в том числе и повышенной пищевой ценности. Определены общие направления в совершенствовании хлебопекарной промышленности на основе ее цифровизации, базируемой на комплексной взаимосвязи потребителя, производителя, науки и образования. Выводы: Результаты исследования позволят оперативно реагировать на тенденцию изменения спроса на хлебобулочные изделия, разрабатывать и реализовывать новые направления в технологии с учетом современного состояния хлебопекарной отрасли и функционирования отдельных хлебопекарных предприятий.
Role of intestinal microbiota in regulation of immune reactions of gut-associated lymphoid tissue under stress and following the modulation of its composition by antibiotics and probiotics administration
Authors: Topol Inna A. , Polyakova Irina S. , Elykova Anna V.
Published: January 2023

Over the past two decades, active study of the microbial ecosystem of the host organism gastrointestinal tract has led to the recognition of gut microbiome as a "key player" that carries a significant immune pressure and is responsible both for the course of physiological processes and for the development of pathological conditions in humans and animals. A vast number of bacteria living in the human gastrointestinal tract are considered as an organ functioning in dialogue in formation of immunological tolerance, the regulation of normal functional activity of the immune system and maintaining the intestinal mucosa homeostasis. However, disturbances in interaction between these physiological systems is closely related to the pathogenesis of different immune-mediated diseases. In turn, in a large number of works chronic social stress, along with the use of antibiotics, pre- and probiotics, is recognized as one of the leading factors modulating in the microbiota of the gastrointestinal tract. This review focuses on the role of the gut microbiome in the regulation of immune responses of GALT under stress and modulation of its composition by antibiotics and probiotics administration.
Molecular epidemiological study of clinical cases of acute hepatitis E in Belarus
Authors: Davydov Vladimir V. , Zhavoronok Sergey V. , Znovets Tatyana V. , Tsyrkunov Vladimir M. , Babenkа Andrei S. , Marchuk Svetlana I. , Gasich Elena L. , Novik Tatiana P. , Alatortseva Galina I. , Mikhailov Mikhail I. , Zverev Vitaly V.
Published: January 2023

Relevance. The frequency of occurrence of anamnestic antibodies to the hepatitis E virus (HEV) in the general population of the Republic of Belarus is 7.3%, which is clearly not consistent with the low incidence of hepatitis E (HE). Most of primary HEV infections remain undiagnosed. The intensive epidemic process of HEV in the Belarusian population is hidden. Conducting epidemiological studies, including genotyping of HEV sequences isolated on the territory of the republic, makes it possible to more accurately characterize the sources of HEV infection and the mechanisms of its transmission.
Aim molecular epidemiological study of two cases of acute hepatitis E detected in patients from Belarus.
Materials and methods. During 20212022, samples of biological material were obtained from two patients undergoing treatment with an established diagnosis of acute hepatitis E. Serum samples were tested to detect antibodies to HEV using enzyme immunoassay, HEV RNA was detected in fecal samples using nested RT-PCR. The nucleotide sequence was determined by an automatic sequencer using the Sanger method. Analysis of nucleotide sequences, their genotyping, and calculation of evolutionary distances were performed using MEGA X software.
Results. The HEV sequence isolated from a pregnant woman who had an epidemiological episode of alimentary contact with raw pork meat is clustered into a common phylogenetic clade with HEV sequence obtained from the patient from Belarus with a history of kidney transplantation and HEV sequences isolated from a domestic pigs. The HEV sequence isolated from a patient with a history of travel to Pakistan belongs to the HEV genotype 1 and joins a clade of HEV sequences isolated in Pakistan, India, Nepal and Mongolia.
The effect of preventive vaccination on chickenpox incidence in Russia
Authors: Afonina Nataliya M. , Mikheeva Irina V.
Published: January 2023

Introduction. The significance of the chickenpox (CP) problem for public health and economy of Russia necessitated inclusion of CP vaccination in the regional immunization programs of some regions of the Russian Federation and in the vaccination schedule as an epidemic-response measure.
The purpose of the study was to assess the effectiveness of CP vaccination to provide the rationale for recommendations on expansion of the national preventive vaccination schedule.
Materials and methods. The vaccination effectiveness was assessed by comparison of the vaccination rates and CP incidence rates in 20062021 with the reference to the data collected from forms No. 2 and No. 5 of the National Statistical Monitoring in Russia and in its regions.
Results and discussion. Before 2019, in some regions of Russia, CP vaccination of children within regional immunization programs and vaccination of risk groups within the vaccination schedule following the epidemic-response measures had hardly any effect on the epidemiological situation. The remote-work and stay-at-home policies during the COVID-19 pandemic in 2020 resulted in a decrease in the incidence and an increased number of individuals who did not have immunity against Varicella zoster, thus subsequently leading to the increased CP incidence in the country. However, the Central, Volga, and Siberian Federal Districts were able to avoid an increase in the CP incidence due to the significantly increased vaccination coverage among children in 20202021. At the same time, in most of the regions, less than 2% of children aged 16 years were vaccinated annually. The insufficient CP vaccination coverage in the regions having extensive experience of planned immunization of children led to the shift of the incidence towards older age groups and increased risk of development of congenital infection.
Conclusion. To increase the effectiveness of CP preventive vaccination, it is recommended that the national vaccination schedule should include two-dose vaccination with the coverage of at least 90% of one-year-old children, while continuing immunization of older age individuals from the groups that are at risk of infection.
The Influence of Directive Leadership Style, Motivation, and Discipline on Performance Personil Kompi 1 Batalyon B Pelopor Brimob Sumbawa
Authors: Nurdin Nurdin , Yamin Ahmad , Insan Imammul
Published: January 2023

Performance really needs to be considered, where performance is used as an expression of a person's ability to carry out a job. Good performance can be seen from the directive leadership style. Where leadership style is the way a leader influences the behavior of subordinates, so they are willing to work together and want to work productively to achieve organizational goals. In addition to leadership style, motivation is also needed in improving performance. Then performance can also be influenced by the discipline of human resources in the environment. This research was conducted at Company 1 Battalion B Pioneer, where there are still obstacles in improving the performance of its personnel including those related to directive leadership, where there are still Company 1 Battalion B Pioneer personnel aged over 40 years and in rank (Nintara and Tamtama) as well. many senior personnel. So this study aims to analyze the influence of directive leadership style, motivation, and discipline on the performance of Company Personnel 1 Battalion B Pioneer – Brimob Sumbawa. This research is a quantitative research. The sampling technique used by the researcher is a saturated sample, that is, the entire population is used as a sample. Where the number of personnel of Company 1 Battalion B Pioneer – Brimob Sumbawa is 120 personnel. Data collection techniques carried out by researchers by distributing questionnaires. The data were analyzed using a statistical software (statistical software) in the form of a statistical package for social science (SPSS) application. Based on the results of the study, it can be concluded that: 1) The directive leadership style has no effect on the performance of the personnel of Company 1 Battalion B Pioneers – Brimob Sumbawa; 2) Motivation affects the performance of Company 1 Battalion B Pioneer personnel – Brimob Sumbawa; 3) Discipline affects the performance of Company 1 Battalion B Pioneer personnel – Brimob Sumbawa
The Managerial Influence of The Principal on Improving The Performance of Elementary School Teachers In Cluster 2 Plampang District
Authors: Ardiansyah Ahyar , Umar Umar , W Yunanri
Published: January 2023

The background of this research is related to the low performance of elementary school teachers in Cluster 2, Plampang District. The main problem is the ability of the principal's managerial skills in carrying out his functions.  The purpose of this study is to determine the effect of the principal's managerial application on teacher performance. This research was conducted using a non-experimental quantitative approach. The population and sample in this study were 62 people. The instrument used in this study was to use a closed questionnaire with answer choices on a likert scale of 4, which means that respondents can only choose one answer. The data analysis techniques in this study are descriptive analysis and simple regression analysis. The result showed: (1) the principal's managerial implementation process towards improving teacher’s performance has gone well, (2) there is a managerial correlation of the principal to teacher’s performance, as evidenced by the results of the counting test of 9,151 > ttabel 1.66. The correlation of the principal's managerial influence on teacher’s performance was 0.687 in the strong category. The magnitude of the effect of the principal's managerial effectiveness on teacher’s performance was 58.3%, (3) there is an influence of the principal's managerial effectiveness on teacher’s performance, as evidenced by the results of the paired sample t-test showing that the significance amounts to 0.000 < 0.05, so there is a noticeable or significant difference between the principal's managerial influence on teacher performance. The research advice is for the headmaster to continuously improve his managerial skills, and for teachers it is advisable to always improve his performance.
Pemberdayaan Ibu-ibu PKK melalui Pelatihan Pembuatan Buket Snack sebagai Alternatif Peluang Usaha Untuk Meningkatkan Pendapatan Keluarga
Authors: Lidyana Novita , Anggun Dwi
Published: January 2023

Pengabdian pada masyarakat dilakukan oleh dosen Universitas Panca Marga Probolinggo dan mahasiswa peserta KKN Desa Bulang yang dilaksanakan di Dusun Klompang Desa Bulang Kecamatan Gending Kabupaten Probolinggo dengan jumlah peserta sebanyak 10 orang adalah ibu-ibu PKK. Kegiatan ini merupakan salah satu pelatihan kewirausahaan membuat buket snack sebagai salah satu alternative peluang usaha dimana nantinya dengan inovasi pembuatan buket snack ini dapat meningkatkan pendapatan keluarga. Metode pelaksanaan yang digunakan dalam pengabdian masyarakat menggunakan Metode Penyuluhan dan Metode Pelatihan pada kegiatan awal dilakukan dengan metode penyuluhan dengan materi Kreativitas, Peluang Usaha, dan Cara Memulai Berwirausaha dan dilakunjutkan dengan pelatihan pembuatan buket snack. Hasil yang didapatkan dari kegiatan pengabdian masyarakat ini, terjadi peningkatan pengetahuan peserta pelatihan dalam hal ini adalah ibu-ibu PKK tentang cara membuat buket snack sebagai alternatif peluang usaha untuk meningkatkan pendapatan keluarga
Empowering PKK Mothers through Training on Making Snack Bouquets as An Alternative Business Opportunity to Increase Family Income
Community service was carried out by lecturers of Panca Marga University of Probolinggo and students participating in the Bulang Village KKN which was held in Klompang Hamlet, Bulang Village, Gending District, Probolinggo Regency with a total of 10 participants being PKK mothers. This activity is one of the entrepreneurship trainings to make a bouquet of snacks as an alternative business opportunity where later with the innovation of making this snack bouquet can increase family income. The implementation method used in community service using the Counseling Method and Training Method in the initial activity was carried out by the counseling method with the material Creativity, Business Opportunities, and How to Start Entrepreneurship and was carried out with training on making snack bouquets. The results obtained from this community service activity, there was an increase in the knowledge of the trainees in this case pkk mothers about how to make a bouquet of snacks as an alternative business opportunity to increase family income
Peningkatan Produktivitas Guru SMK melalui Kreativitas Pembuatan Bahan Ajar E-Learning
Authors: Ferawati Ferawati , Saputri Fiqih Hana , Nurmaesah Nunung
Published: January 2023

Perkembangan materi e-learning yang mengikuti perkembangan teknologi yang masih terbatas dan materi yang digunakan guru dalam kegiatan pembelajarannya terbatas pada buku untuk siswa dan buku untuk guru. Hal ini berdasarkan hasil survei yang telah dilakukan di SMK Bina Mandiri bahwa belum menggunakan e-learning.  Upaya dan tindakan yang sesuai dengan situasi saat ini diperlukan berupa pelatihan dan pendampingan yang harus diberikan untuk mengatasi permasalahan mitra. Kegiatan ini bertujuan agar para guru dapat membuat materi e-learning berdasarkan keahliannya. Metode dalam pelaksanaan pengabdian ini terdiri dari tahap perencanaan, pelaksanaan dan evaluasi. Kegiatan pengabdian ini diikuti oleh 13 guru-guru di SMK Bina Mandiri dan dilaksanakan pada tanggal 15 sampai 20 Agustus 2022 selama 5 (lima) hari secara luring berupa suatu pelatihan dan pendampingan. Hasil kegiatan pengabdian ini pendampingan dan pelatihan untuk menggunakan aplikasi e-learning. Kegiatan pengabdian ini terlaksana dengan baik berdasarkan hasil Kegiatan pengabdian ini terlaksana dengan baik terbukti dengan adanya pengabdian setelah kegiatan selesai. Selain itu, peserta kegiatan masih membutuhkan pelatihan serupa dengan menggunakan aplikasi e-learning jenis lain.
Increasing the Productivity of Vocational High School Teachers to Increase Potential in Facing the Digital Economy through Creativity in Making E-Learning Teaching Materials
 The competence of teachers in developing current e-learning teaching materials following technological developments is still very limited, and the teaching materials used by teachers in learning activities are only limited to student books and teacher books. Efforts and actions following the current situation are needed in the form of training and assistance as a form of community service that needs to be done to bridge the existing problems. This community service activity has the aim that teachers can make e-learning teaching materials based on their expertise. The method of implementing this service consists of the planning, implementation and evaluation stages. This service activity was attended by 13 teachers at Bina Mandiri Vocational School and was held from 15 to 20 August 2022 for 5 (five) days offline in the form of training and mentoring. The results of this service activity include: 1) Providing training so that teachers know the competence of their respective fields to develop e-learning teaching materials according to competencies. 2) Can guide teachers to create e-learning teaching materials concepts according to their field of expertise. 3) Assist teachers in making e-learning teaching materials following the concepts that have been made. 4) Can provide knowledge about any platforms used as e-learning teaching materials. This service activity was carried out well, as evidenced by the service participants' reactions after completing it. In addition, activity participants still need similar training using other media or e-learning applications.
Pemberdayaan Kelompok Tani Siparakai Melalui Pengembangan Usaha Sayuran Aquaponik Melalui Teknologi Budikdamber Di Kab.Takalar
Authors: Jabir Nur Mu'min , Ashari Ahmad Firman
Published: January 2023

Tujuan pemberdayaan masyarakat untuk meningkatkan pengetahuan dan keterampilan serta perubahan sikap dari kelompok tani agar mampu menerapkan teknologi budikdamber.Kegiatan Pengabdian ini dilakukan di kelurahan Kalabbirang, Kecamatan Pattalassang, Kab. Takalar.yang dihadiri oleh Kepala Kelurahan, serta mitra kelompok tani sebanyak 30 orang.metode kegiatan yang dilakukan yaitu:1. Pelatihan teknik pembuatan instalasi aquaponik budikdamber memanfaatkan lahan pekarangan rumah warga, 2. Pelatihan teknik pengemasan dan pelabelan produk, 3. Pelatihan menajemen pemasaran produk. Hasil Pengabdian ini dapat meningkatkan pengetahuan,keterampilan dan sikap peserta pelatihan sehingga mampu menghasilkan produk sayuran aquaponik dan hasil  ikan dari budikdamber  yang sehat, produk tersebut selain dapat digunakan sendiri juga dapat dijual karena memiliki potensi pasar yang luas  khususnya membantu perekonomian dan ketahanan pangan masyarakat dimasa pandemi Covid-19. desa mengetahui cara instalasi teknologi budikdamber yang Kesimpulannya adalah masyarakat desa kalabbirang dapat meningkatkan kemampuanya dalam pengembangan usaha sayuran aquaponik melalui penerapan teknologi budikdamber.
Empowerment of Siparakai Farmer Group through Aquaponic Vegetable Business Development of Budikdamber Technology in Takalar Regency
 The purpose of community empowerment is to increase knowledge and skills as well as change the attitude of farmer groups so that they are able to apply Budikdamber technology. Takalar, which was attended by the Village Head, as well as 30 farmer group partners. The methods of the activities carried out were: 1. Training on techniques for making Budikdamber aquaponics installations using residents' yards, 2. Training on product packaging and labeling techniques, 3. Product marketing management training. The results of this service can improve the knowledge, skills and attitudes of the training participants so that they are able to produce aquaponic vegetable products and fish products from healthy budikdamber, these products can not only be used alone, they can also be sold because they have broad market potential, especially helping the economy and food security of the community during the pandemic. Covid-19. The village knows how to install the budikdamber technology. The conclusion is that the people of the village of kalabbirang can improve their abilities in developing aquaponic vegetable business through the application of budikdamber technology.