bluuebunny/crossref_metadata_2025 huggingface dataset:
Morfología urbana y análisis tipológico en la conformación arquitectónica del Centro Histórico de San Luis Potosí
Authors: Jiménez Anguiano Daniel
Published: February 2023

La conservación del patrimonio edificado es siempre un tema complejo que incluye muy diversas visiones y áreas de actuación, entre las cuales se destaca la comprensión de la conformación morfológica de estos entornos y los valores que en ellos se inscriben, los cuales pueden ser abordados a partir del análisis de tipos arquitectónicos. Es pertinente que el desarrollo de estos estudios deba darse, más que en términos meramente estilísticos, en una reflexión crítica que permita ubicarnos como sociedad en su contexto cultural e histórico, donde la comprensión de estos tipos ideales, sirva para comparar arquitecturas.

De igual manera, el estudio también persigue, mediante el análisis crítico de tipologías, la posibilidad de apropiación de una herramienta en la enseñanza de la arquitectura, donde se pueda voltear la mirada hacia una aproximación objetiva de aquellos elementos del pasado que se han arraigado en nuestra cultura y con ello puedan forjarse esquemas repetibles.
Diseño concientizado de productos, una estrategia para el aprovechamiento de residuos orgánicos
Authors: Hernández Neria Gerardo , Santamaría Ortega Arturo , Urbina Pérez Gerson
Published: February 2023

En la actualidad, el uso irracional de materiales y la fabricación excesiva de productos han generado desmedidos niveles de impactos ambientales y una disminución considerable de los recursos naturales. Por lo tanto, es necesaria la reintegración de los residuos de productos a un nuevo ciclo de vida. De esta manera, se propone la concientización del proceso de diseño para el desarrollo de estrategias de consumo y uso racional de recursos, principalmente el aprovechamiento de los residuos, en especial los de origen orgánico ya que se considera tienen propiedades adecuadas para fabricar productos de consumo. Como caso de estudio, se muestra que los residuos de la naranja se generan en cantidades alarmantes y no tienen una disposición adecuada, por lo que, se aplica el método de aprovechamiento concientizado de residuos en las cascaras de naranja para fabricación de nuevos productos.
El diseño: factor de innovación para crear valor
Authors: Gómez Vera Laura Teresa , Zendejas Santín Verónica
Published: February 2023

El escaso reconocimiento de la actividad inventiva en el país dificulta la relación y el intercambio de las prácticas académicas con las empresas. Este artículo es una reflexión crítica para potenciar la gestión del diseño, particularmente en materia de propiedad intelectual y ampliar la cooperación con otros grupos académicos, equipos gubernamentales o corporaciones lucrativas, con la finalidad de establecer prioridades a través de la experiencia compartida.
La participación comunitaria como forma de apropiación de espacios públicos en conjuntos habitacionales multifamiliares de San Luis Potosí, S.L.P., 1958-2016
Authors: Gutiérrez Sánchez Víctor Manuel , Peraza Guzmán Marco Tulio
Published: February 2023

La vitalidad de un lugar depende tanto de los espacios interiores como de los exteriores que lo integran, pero el espacio público es donde principalmente se consolida el tejido social en los conjuntos habitacionales urbanos, especialmente en aquellos de mayor densidad poblacional, como los multifamiliares. Esta consolidación depende, en gran medida, de la participación de los vecinos en las actividades que les empoderan para incidir en la transformación del espacio en un lugar de recreación y esparcimiento comunitario con altos índices de vitalidad. Si los vecinos no participan en las etapas de diseño y construcción de los espacios públicos en torno a sus viviendas, porque los encuentran como algo definido a priori, por iniciativa de los ámbitos gubernamentales y empresariales en los desarrollos habitacionales, entonces es por medio de participación vecinal que pueden adquirir el poder de incidir en la apropiación física y simbólica del espacio público.
El nopal y la tuna, símbolos culturales en el arte mexicano. Usos e identidad en un ejido rural en Coahuila
Authors: Pérez-Gavilán A. Ana Isabel , Cerecero Alvarado Alejandro , Pérez Cervantes Alejandro
Published: February 2023

Este artículo traza un panorama general sobre las propiedades y usos del nopal, cactus nativo de América con una fuerte carga identitaria para México desde tiempos prehispánicos. Se definen sus propiedades y su utilización ancestral y actual en la gastronomía, la medicina y la construcción tradicionales, para plantear los significados míticos e históricos del nopal y su fruto, la tuna, a través de representaciones destacadas en el arte mexicano prehispánico, virreinal, moderno y contemporáneo. El texto explora los significados identitarios nacionales de esta cactácea para trasplantarlos a Coahuila, en el contexto de una comunidad rural con bajos índices educativos y una economía agrícola de temporal. Como resultado de una investigación aplicada de artes y diseño en torno a productos artesanales de nopal y tuna en el ejido el Cedrito del municipio de Arteaga, Coahuila. Con ello se plan tea una posible comprensión de los parámetros culturales y simbólicos.
Habitabilidad, accesibilidad y sustentabilidad de la vivienda social en México
Authors: Arista González Gerardo , Aguillón Robles Jorge , Narváez Hernández Lilia
Published: February 2023

Ante la complejidad de la situación, una alternativa para abordar y atender el asunto de la vivienda en México, es una que evita analizarlo solamente desde sus dimensiones instrumentales, técnicas o materiales, sino más bien desde otras que son más integradoras de todos los factores incidentes. La investigación tiene por objeto realizar una investigación transdisciplinar de nuevas variables que afectan actualmente a la vivienda social en México, incorporando aspectos como habitabilidad, accesibilidad y sustentabilidad. Se trata de una compilación y análisis de información relativa a indicadores que tradicionalmente son abordados por nuestra disciplina como los relativos al diseño, funcionamiento, expresión, espacialidad, lo técnico y constructivo, etc. y que en lo futuro deberán ser complementados con aspectos sociales, ambientales y de confort térmico, a través de un análisis transdisciplinar que aborde temas sobre el mejoramiento de la calidad de vida de sus habitantes.
Något om Bibeln som politiskt dokument i undervisning och modern historia
Authors: Bengtsson Håkan
Published: February 2023

N/A
Populism and Biblical Studies, Part 1: The Continuation of a Debate, with a Response to Robert W. Yarbrough
Authors: Kelhoffer James A.
Published: February 2023

N/A
Att vara "gammaltestamentlig": Tillskrivna betydelser till ordet "gammaltestamentlig" i svenska dagstidningar 1987–2017
Authors: Liljefors Hanna
Published: February 2023

N/A
Mer än filologi: Textkritiska positioner i Svenska Folkbibeln och Bibel 2000
Authors: Pleijel Richard
Published: February 2023

N/A
Sentimen Analisis Vaksin Covid-19 Menggunakan Naive Bayes Dan Support Vector Machine
Authors: Alita Debby , Shodiqin RB Ali
Published: February 2023

Vaccine administration in Indonesia has now reached the booster vaccine stage, various types of vaccines have been given to the Indonesian people from the Sinovac, AstraZeneca, Sinopharm, Moderna, Pfizer vaccines, etc. Not a few Indonesian people use several types of vaccines that are offered up to booster vaccines, but there are some people who think they are still infected with this Covid virus with severe symptoms. Another opinion is that there is also a vaccine. In 2019, people were shocked by a new virus from Wuhan, China, namely the corona virus or called COVID-19 (Corona Virus Disease 2019). The government invites the public to get the Covid-19 vaccine in order to form herd immunity or group immunity to the Covid-19 virus. Sentiment analysis can be used to evaluate a service performance and so on. So the author will conduct a comparison between the Naive Bayer Classifier method and the Support Vector Machine to find out which method is more efficient in knowing people's accurate views of the Covid-19 vaccine. The performance test results of the two methods show that the performance of the Naive Bayes Classifier method (Accuracy 72.88%, Precision 43.49%, Recall 54.95%, and average performance 57.10%) is higher than the average performance of the Support Vector Machine method (Accuracy 77.00% , Precision 75.00%, Recall 7.70%, and average performance 53.52%). Based on the average performance value of the Naive Bayes Classifier method, it can be considered more efficient than the Support Vector Machine method.
The Effect of Celebrity Endorsement on Young Consumer Purchase Intention in Bangladesh: An Empirical Study
Authors:   University of Barishal, Khanam Marzia , Hossain Md. Abir ,   University of Barishal
Published: February 2023

Purpose: The purpose of this study is to investigate the effect of celebrity endorsement components (expertise, attractiveness, and trustworthiness) on brand attitude, brand loyalty, and purchase intention. This study looks at the elements of celebrity endorsements that influence young consumers' purchasing preferences in the Barishal region of Bangladesh. Methodology: The study model incorporates constructs from earlier literature that have been proven to have substantial relations with purchasing intention. A self-administered questionnaire has been used through an online survey to collect 205 data from young people aged 20 to 24. Additionally, SPSS has been used to analyze the data. Findings: The study demonstrates that celebrity expertise and trustworthiness significantly influence brand attitudes and brand loyalty. However, celebrity attractiveness is not much impacted by brand attitudes and brand loyalty. The study also demonstrates that brand loyalty is the most substantial influence on purchase intention. Practical Implications: The findings of this study will help producers, marketers, merchants, and advertisers figure out what traits of a celebrity contribute to a favorable brand attitude, brand loyalty, and buy intention. Originality: This paper empirically examines how different variables affect celebrity endorsement’s influence on the buying behaviour of consumers’ decisions of young customers. Research Limitations: In this study, the respondents are young, so the findings may not be applicable on a general basis.
Contribution of cultural interests to subjective well-being of youth in Serbia
Authors: Jokić Biljana , Mrđa Slobodan
Published: February 2023

Research shows that cultural interests contribute to subjective well-being, but results are not highly consistent. This study on the youth in Serbia (N = 453) is aimed at exploring: 1. factorial structure of favourite leisure activities, 2. their contribution to well-being, along with socio-demographics, physical health, and engagement on social networks, and 3. whether and how results differ depending on operationalization of the criterion variable (subjective happiness, SH vs. satisfaction with life, SWL). The results show that physical health and favourite leisure activities (cultural interests and folk & family) are significant predictors of both SH (along with sport and a larger number of social networks profiles) and SWL (along with expenditure for culture and home/entertainment).
(Not) Surviving the Night
Authors: Davies Fiona
Published: February 2023

While traditionally regarded as one of the many liminal nocturnal spaces within the often-labyrinthine complexes of contemporary hospitals, the corridor is not inscribed with specific activities, rules of conduct or dress codes. Instead, particularly at night they become in-between places of ambiguity and ambivalence. As a family member of an ICU patient, frequently you are asked to step outside while medical staff undertake some procedure. This can occur at any time of the night. In the early hours after midnight the family can be left to wander the darkened corridors, led on by the glow of the vending machines all safely locked inside the building and yet out of ICU. This experience of liminal nocturnal temporality by going beyond that expected of being in transition, can linger to become semi-permanent, and therefore alter the perception of the transition from life to death so that it may feel suspended, stalled, or never-ending.
Working Interviews: Blending Fieldwork and Technical Work on Tour with Cirque du Soleil
Authors: Danson Faraday Jacob
Published: February 2023

For Cirque du Soleil’s touring arena show Corteo, music is a central feature of every performance. In this article, I focus on Corteo’s touring sound technicians, who play an essential role in the show’s musical presentation. I discuss a methodological approach to my ethnographic research, which provides new insights into large-scale intermedia performance environments like Corteo. I theorize a masculine-gendered, stoic mode of emotional labour that is enacted through voice-to-voice remote communication during performance. Through participant observation, public intercept interviews, and what I call “working interviews”—interviews with the sound technicians that take place during performances or other operational activities—I engage directly with the technical and emotional labour practices of musical production.
Valsts parāds: finansiālās drošības novērtējums un optimālas politikas izvēle
Authors: Semjonova Nadežda
Published: February 2023

Zinātniskajā monogrāfijā “Valsts parāds: finansiālās drošības novērtējums un optimālas politikas izvēle” apkopoti pētījumu rezultāti, kas balstās uz 2003.–2012. gada pasaules ekonomikas un valsts parāda radītājiem. Monogrāfijā autore iepazīstina ar savu izstrādāto paplašināto defoltu veidu klasifikāciju, analizē valsts parāda dinamikas tendences Latvijā, kā arī novērtē savstarpējās sakarības starp valsts parādu un valsts ekonomiskajiem un finanšu rādītājiem Eiropā un citos pasaules reģionos.
Narrativas del yo desde las cárceles de la represión política argentina: los "Cuadernos" de Alicia Kozameh
Authors: Pietrak Mariola
Published: February 2023

El objeto de este estudio son las narrativas del yo escritas por las presas políticas en las cárceles de la última dictadura argentina (1976-1983) y los años de la Triple A (1973-1976). Son textos tan diversos como diversas son sus autoras en lo que se refiere a su edad, clase, partido político, etc. Sin embargo, en su conjunto acusan el esfuerzo por conservar la identidad y la integridad de las presas frente al plan sistemático de aniquilamiento de opositores realizado por el régimen militar, lo cual permite leerlos en clave autobiográfica. En este espacio, nos centramos particularmente en la producción de Alicia Kozameh, cuyos cuadernos son un proyecto sólido de dejar constancia del yo en circunstancias de extrema adversidad, además de un interesante ejercicio autobiográfico desde dos orillas: los "Cuadernos carcelarios" (1977-1978), crípticos y fragmentarios, esbozan un yo contra la privación de la autorreflexividad del sujeto aprisionado, mientras que los "Cuadernos explicativos" (2010) reconstruyen aquel yo fracturado desde la distancia y la libertad del presente.
Nuclear export inhibition jumbles epithelial–mesenchymal states and gives rise to migratory disorder in healthy epithelia
Authors: Krull Carly M , Li Haiyi , Pathak Amit
Published: February 2023

Dynamic nucleocytoplasmic transport of E-M factors regulates cellular E-M states; yet, it remains unknown how simultaneously trapping these factors affects epithelia at the macroscale. To explore this question, we performed nuclear export inhibition (NEI) via leptomycin B and Selinexor treatment, which biases nuclear localization of CRM1-associated E-M factors. We examined changes in collective cellular phenotypes across a range of substrate stiffnesses. Following NEI, soft substrates elevate collective migration of MCF10A cells for up to 24 hr, while stiffer substrates reduce migration at all time points. Our results suggest that NEI disrupts migration through competition between intercellular adhesions and mechanoactivation, generally causing loss of cell–cell coordination. Specifically, across substrate stiffnesses, NEI fosters an atypical E-M state wherein MCF10A cells become both more epithelial and more mesenchymal. We observe that NEI fosters a range of these concurrent phenotypes, from more epithelial shYAP MCF10A cells to more mesenchymal MDCK II cells. α-Catenin emerges as a potential link between E-M states, where it maintains normal levels of intercellular adhesion and transmits mechanoactive characteristics to collective behavior. Ultimately, to accommodate the concurrent states observed here, we propose an expanded E-M model, which may help further understand fundamental biological phenomena and inform pathological treatments.
Pharmacometrics of high-dose ivermectin in early COVID-19 from an open label, randomized, controlled adaptive platform trial (PLATCOV)
Authors: Schilling William HK , Jittamala Podjanee , Watson James A , Ekkapongpisit Maneerat , Siripoon Tanaya , Ngamprasertchai Thundon , Luvira Viravarn , Pongwilai Sasithorn , Cruz Cintia , Callery James J , Boyd Simon , Kruabkontho Varaporn , Ngernseng Thatsanun , Tubprasert Jaruwan , Abdad Mohammad Yazid , Piaraksa Nattaporn , Suwannasin Kanokon , Hanboonkunupakarn Pongtorn , Hanboonkunupakarn Borimas , Sookprome Sakol , Poovorawan Kittiyod , Thaipadungpanit Janjira , Blacksell Stuart , Imwong Mallika , Tarning Joel , Taylor Walter RJ , Chotivanich Vasin , Sangketchon Chunlanee , Ruksakul Wiroj , Chotivanich Kesinee , Teixeira Mauro Martins , Pukrittayakamee Sasithon , Dondorp Arjen M , Day Nicholas PJ , Piyaphanee Watcharapong , Phumratanaprapin Weerapong , White Nicholas J ,   on behalf of the PLATCOV Collaborative Group
Published: February 2023

Background:

There is no generally accepted methodology for in vivo assessment of antiviral activity in SARS-CoV-2 infections. Ivermectin has been recommended widely as a treatment of COVID-19, but whether it has clinically significant antiviral activity in vivo is uncertain.

Methods:

In a multicentre open label, randomized, controlled adaptive platform trial, adult patients with early symptomatic COVID-19 were randomized to one of six treatment arms including high-dose oral ivermectin (600 µg/kg daily for 7 days), the monoclonal antibodies casirivimab and imdevimab (600 mg/600 mg), and no study drug. The primary outcome was the comparison of viral clearance rates in the modified intention-to-treat population. This was derived from daily log10 viral densities in standardized duplicate oropharyngeal swab eluates. This ongoing trial is registered at https://clinicaltrials.gov/ (NCT05041907).

Results:

Randomization to the ivermectin arm was stopped after enrolling 205 patients into all arms, as the prespecified futility threshold was reached. Following ivermectin, the mean estimated rate of SARS-CoV-2 viral clearance was 9.1% slower (95% confidence interval [CI] –27.2% to +11.8%; n=45) than in the no drug arm (n=41), whereas in a preliminary analysis of the casirivimab/imdevimab arm it was 52.3% faster (95% CI +7.0% to +115.1%; n=10 (Delta variant) vs. n=41).

Conclusions:

High-dose ivermectin did not have measurable antiviral activity in early symptomatic COVID-19. Pharmacometric evaluation of viral clearance rate from frequent serial oropharyngeal qPCR viral density estimates is a highly efficient and well-tolerated method of assessing SARS-CoV-2 antiviral therapeutics in vivo.

Funding:

‘Finding treatments for COVID-19: A phase 2 multi-centre adaptive platform trial to assess antiviral pharmacodynamics in early symptomatic COVID-19 (PLAT-COV)’ is supported by the Wellcome Trust Grant ref: 223195/Z/21/Z through the COVID-19 Therapeutics Accelerator.

Clinical trial number:

NCT05041907.
Orai3 and Orai1 mediate CRAC channel function and metabolic reprogramming in B cells
Authors: Emrich Scott M , Yoast Ryan E , Zhang Xuexin , Fike Adam J , Wang Yin-Hu , Bricker Kristen N , Tao Anthony Y , Xin Ping , Walter Vonn , Johnson Martin T , Pathak Trayambak , Straub Adam C , Feske Stefan , Rahman Ziaur SM , Trebak Mohamed
Published: February 2023

The essential role of store-operated Ca2+ entry (SOCE) through Ca2+ release-activated Ca2+ (CRAC) channels in T cells is well established. In contrast, the contribution of individual Orai isoforms to SOCE and their downstream signaling functions in B cells are poorly understood. Here, we demonstrate changes in the expression of Orai isoforms in response to B cell activation. We show that both Orai3 and Orai1 mediate native CRAC channels in B cells. The combined loss of Orai1 and Orai3, but not Orai3 alone, impairs SOCE, proliferation and survival, nuclear factor of activated T cells (NFAT) activation, mitochondrial respiration, glycolysis, and the metabolic reprogramming of primary B cells in response to antigenic stimulation. Nevertheless, the combined deletion of Orai1 and Orai3 in B cells did not compromise humoral immunity to influenza A virus infection in mice, suggesting that other in vivo co-stimulatory signals can overcome the requirement of BCR-mediated CRAC channel function in B cells. Our results shed important new light on the physiological roles of Orai1 and Orai3 proteins in SOCE and the effector functions of B lymphocytes.
The polarization of microglia and infiltrated macrophages in the injured mice spinal cords: a dynamic analysis
Authors: Li Jing-Lu , Fu Gui-Qiang , Wang Yang-Yang , Bian Ming-Ming , Xu Yao-Mei , Zhang Lin , Chen Yu-Qing , Zhang Nan , Ding Shu-Qin , Wang Rui , Fang Rui , Tang Jie , Hu Jian-Guo , Lü He-Zuo
Published: February 2023

Background

Following spinal cord injury (SCI), a large number of peripheral monocytes infiltrate into the lesion area and differentiate into macrophages (Mø). These monocyte-derived Mø are very difficult to distinguish from the local activated microglia (MG). Therefore, the term Mø/MG are often used to define the infiltrated Mø and/or activated MG. It has been recognized that pro-inflammatory M1-type Mø/MG play “bad” roles in the SCI pathology. Our recent research showed that local M1 cells are mainly CD45−/lowCD68+CD11b+ in the subacute stage of SCI. Thus, we speculated that the M1 cells in injured spinal cords mainly derived from MG rather than infiltrating Mø. So far, their dynamics following SCI are not yet entirely clear.

Methods

Female C57BL/6 mice were used to establish SCI model, using an Infinite Horizon impactor with a 1.3 mm diameter rod and a 50 Kdynes force. Sham-operated (sham) mice only underwent laminectomy without contusion. Flow cytometry and immunohistofluorescence were combined to analyze the dynamic changes of polarized Mø and MG in the acute (1 day), subacute (3, 7 and 14 days) and chronic (21 and 28 days) phases of SCI.

Results

The total Mø/MG gradually increased and peaked at 7 days post-injury (dpi), and maintained at high levels 14, 21 and 28 dpi. Most of the Mø/MG were activated, and the Mø increased significantly at 1 and 3 dpi. However, with the pathological process, activated MG increased nearly to 90% at 7, 14, 21 and 28 dpi. Both M1 and M2 Mø were increased significantly at 1 and 3 dpi. However, they decreased to very low levels from 7 to 28 dpi. On the contrary, the M2-type MG decreased significantly following SCI and maintained at a low level during the pathological process.
Numerical Study of the Thermal Behavior of a Hollow Block with Phase Change Materials (PCM) in the Sahelian Zone
Authors: Zoma Vincent , Kaboré Boureima , Ouedraogo Germain Wende Pouiré , Compaoré Jean Marie , Kam Sié
Published: February 2023

In this work, we present a numerical study of the thermal behavior of a hollow block with or without phase change material (PCM) in the Sahelian zone.

The PCMs used in this study are RT27 paraffin and hydrated salt with a melting temperature of 27°C and 29.9°C respectively and a latent heat of fusion of 179kJ/kg and 184kJ/kg. The equations obtained were adimensionalized then discretized by the finite element method and solved on the COMSOL software. We were first interested in the study of the thermal phase shift, the damping and the evolution of the temperature at the level of the internal wall. In a second phase, we conducted a comparative study between hollow block containing PCM and other construction materials (adobe, BTC and BLT) used in Burkina Faso.

The numerical results obtained show that the temperature of the internal wall of a hollow block containing RT27 is lower than that of a hollow block without PCM, hollow block containing hydrated salt, BTC, BLT and adobe with respectively a temperature difference of 8.354°C; 3.39°C; 5.79°C; 3.97°C and 3.92°C and the difference in terms of phase shift is 1h18min, 6min, 24min, 42min and 6min for the hollow block containing RT27, the hollow block containing hydrated salt, BTC, BLT and adobe.

Therefore, the integration of PCM in building materials increases their thermal inertia.
Dynamics in Surface and Groundwater Irrigation Systems across Districts of Andhra Pradesh, India: An Economic Analysis
Authors: Madhurima U. , Karunakaran K. R. , Panneerselvam S. , Kumar D. Suresh , Pazhanivelan S.
Published: February 2023

The study explores the district wise irrigation scenario of Andhra Pradesh state with special reference to net tank irrigated area that impacted net groundwater irrigation system in the state. The failure in improvement of tank irrigation due to rainfall, technical, physical and institutional factors gave tremendous scope to improvements in groundwater irrigation system of the state. The study is drawn purely from secondary data sources acquired from DES, Government of Andhra Pradesh. The study examines structural changes in district wise irrigation scenario of Andhra Pradesh state over past 5 decades i.e. from 1970 to 2020. Triennium averages are determined in calculating source wise, district wise irrigation scenario. Net irrigation patterns at the district level were investigated using average and percentage analyses, as well as a tank irrigation scenario. To analyze the trends in district’s irrigation water sources over five decades (1970-2020), compound annual growth rate has been estimated by dividing the entire period into two phases of 25 years each i.e. Phase I (TE 1970 – 94) and Phase – II (1995 – 2020). Net canal irrigated area is found to be dominant in districts of Guntur, Krishna, East Godavari and West Godavari with 305, 189, 167 and 150 thousand hectares. Viziaganagaram registered to have highest net tank irrigated of 64 thousand hectares followed by Srikakulam with 51 thousand hectares, Nellore 41 thousand hectares and Visakahapatnam 20 thousand hectares. The overall increase in net groundwater irrigation was found to be highest in districts of West Godavari coupled with canal irrigation and Ananthapur, Chiittoor, Cuddapah and Kurnool districts during TE 2020-21. The districts Ananthapur, chittoor, Cuddapah have less chances of tank irrigation rehabilitation and reclamation as the net reduction is severe due to vagaries of climate. Proper maintenance and rehabilitation program may reclaim the tank irrigation in districts of Vizianagaram, Srikakulam, Visakahapatnam and Nellore.
Psychological Research Progress in Patient with Lung Cancer: An Overview
Authors: Zhang Tianle , Wang Jingna , Feng Xiujuan , Liang Rui , Jiao Wenyan
Published: February 2023

(1) Through the research, the psychological problems of cancer patients provide effective nursing measures to provide theoretical basis; (2) By improving the psychological problems of cancer patients, and then improve the family care enthusiasm, so as to improve the quality of life of patients.

Methods: The literature with psychological problems of lung cancer patients as key words was collected through CNKI.

Results: According to the results of literature analysis, demographic factors such as age, education level, residence, family income, cancer stage, coping style and other factors have a certain degree of influence on the psychological problems of patients with lung cancer chemotherapy.

Conclusion: Different coping styles lead to different degrees of psychological problems in patients. Positive coping styles mainly reduce the psychological pressure of patients, but also have a positive impact on the treatment and recovery of patients' diseases.
Dissemination of the Results of Pediatric Clinical Trials Funded by the US National Institutes of Health
Authors: Rees Chris A. , Narang Claire , Westbrook Adrianna , Bourgeois Florence T.
Published: February 2023

This study examines practices related to trial registration and results submission in ClinicalTrials.gov and publication of pediatric clinical trials funded by the National Institutes of Health.
Rates of Spontaneous Abortion in Israel Before and During the COVID-19 Pandemic
Authors: Travis-Lumer Yael , Goldberg Yair , Kodesh Arad , Reichenberg Abraham , Sandin Sven , Frangou Sophia , Levine Stephen Z.
Published: February 2023

This cross-sectional study uses electronic health record data to compare monthly incidence rates of spontaneous abortion in Israel before and during the COVID-19 pandemic.
Bicarbonate transport as regulator of antitumour immunity in pancreatic cancer
Authors: Kay Emily J. , Zanivan Sara
Published: February 2023

Bicarbonate transport is a pre‐existing mechanism of pH regulation in pancreatic ductal cells. In a recent study, Cappellesso et al. demonstrated that pancreatic ductal adenocarcinoma metabolic rewiring creates an acidic environment, enhanced by bicarbonate import into cancer cells via SLC4A4. This acidity favours protumourigenic immunosuppression. Targeting SLC4A4 neutralises environmental pH and restores antitumour immunity, sensitising tumours to immune checkpoint blockade.
Untethered Soft Microrobots with Adaptive Logic Gates
Authors: Wang Zichao , Zhang Xuan , Wang Yang , Fang Ziyi , Jiang He , Yang Qinglin , Zhu Xuefeng , Liu Mingze , Fan Xiaodong , Kong Jie
Published: February 2023

Integrating adaptative logic computation directly into soft microrobots is imperative for the next generation of intelligent soft microrobots as well as for the smart materials to move beyond stimulus‐response relationships and toward the intelligent behaviors seen in biological systems. Acquiring adaptivity is coveted for soft microrobots that can adapt to implement different works and respond to different environments either passively or actively through human intervention like biological systems. Here, a novel and simple strategy for constructing untethered soft microrobots based on stimuli‐responsive hydrogels that can switch logic gates according to the surrounding stimuli of environment is introduced. Different basic logic gates and combinational logic gates are integrated into a microrobot via a straightforward method. Importantly, two kinds of soft microrobots with adaptive logic gates are designed and fabricated, which can smartly switch logic operation between AND gate and OR gate under different surrounding environmental stimuli. Furthermore, a same magnetic microrobot with adaptive logic gate is used to capture and release the specified objects through the change of the surrounding environmental stimuli based on AND or OR logic gate. This work contributes an innovative strategy to integrate computation into small‐scale untethered soft robots with adaptive logic gates.
The LIGO‐Virgo O3 Run and the Multi‐Messenger Investigations of Compact Binary Mergers
Authors: Poggiani Rosa ,   for the LIGO/Virgo Collaboration
Published: February 2023

The third observing run (O3) of Advanced LIGO and Advanced Virgo started in April 2019 and ended in March 2020 due to the pandemic. From the O3 run three catalogs of compact binary mergers, GWTC‐2, GWTC‐2.1, and GWTC‐3, that include also some exceptional events, are produced by the LIGO/Virgo Collaboration. The paper will review the science results about compact binary mergers during the O3 run and the follow‐up of gravitational wave candidate events involving the whole electromagnetic spectrum and neutrinos. No confirmed counterpart is found during the O3 run for any candidate. The impact of detected events on astrophysics and cosmology will also be discussed. The paper will also briefly summarize additional multi‐messenger investigations involving candidates not initially associated to gravitational events.
Analysis of statements in documents of gift for academic body donation programs in the United States, and recommendations for future practice
Authors: Johnson Laura E. , McArthur Angela , Schmitt Brandi
Published: February 2023

In US anatomical gift law, the record on which a person consents to body donation after death is referred to as a document of gift (DG). Due to the lack of legal requirements around minimum information standards, enacted recommendations in the United States, and the unknown variation across extant DGs, a review of publicly‐available DGs from US academic body donation programs were performed to benchmark existing statements and recommend specific foundational content for all US DGs. From 117 body donor programs identified, 93 DGs were downloaded (median length three pages, range 1–20). Statements within the DG were qualitatively categorized into 60 codes within eight themes (Communication, Eligibility, Terms of Use, Logistics, Legal References, Financials, Final Disposition, and Signatures), using existing recommendations of academics, ethicists, and professional associations to guide analysis. Of 60 codes, 12 had high disclosure rates (67%–100% of DGs included; e.g., donor personal information), 22 had moderate rates (34%–66%; e.g., discretion to decline a body), and 26 had low disclosure rates (1%–33%; e.g., testing bodies for disease). Some codes with the lowest disclosure frequency were those previously recommended as necessary. Findings highlighted substantial variation in DG statements, with a higher number of baseline disclosure statements than previously recommended. These results present an opportunity to better understand disclosures that have importance for programs and donors alike. Recommendations suggest minimum standards of informed consent practices for body donation programs in the United States. These include clarity around consent processes, consistency of language, and minimum operational standards for informed consent.
Lanthanide Single‐molecule Magnets: Synthetic Strategy, Structures, Properties and Recent Advances
Authors: Wang Jin , Sun Cheng‐Yuan , Zheng Qi , Wang Dan‐Qi , Chen Yu‐Ting , Ju Jian‐Feng , Sun Tong‐Ming , Cui Ying , Ding Yan , Tang Yan‐Feng
Published: February 2023

Single‐molecule magnets (SMMs) show wide potential applications in the field of ultrahigh‐density storage materials, quantum computing, spintronics, and so on. Lanthanide (Ln) SMMs, as an important category of SMMs, open up a promising prospect due to their large magnetic moments and huge magnetic anisotropy. However, the construction of high performance for Ln SMMs remains an enormous challenge. Although remarkable advances are focused on the topic of Ln SMMs, the research on Ln SMMs with different nuclear numbers is still deficient. Therefore, this review summarizes the design strategies for the construction of Ln SMMs, as well as the metal skeleton types. Furthermore, we collect reported Ln SMMs with mononuclearity, dinuclearity, and multinuclearity (three or more Ln spin centers) and the SMM properties including energy barrier (Ueff) and pre‐exponential factor (τ0) are described. Finally, Ln SMMs with low‐nuclearity SMMs, especially for single‐ion magnets (SIMs), are highlighted to understand the correlations between structures and magnetic behavior of the detail SMM properties are described. We expect the review can shed light on the future developments of high‐performance Ln SMMs.
The evolving diagnosis and treatment paradigms of multiple myeloma in China: 15 years' experience of 1256 patients in a national medical center
Authors: Yang Yang , Li Jing , Wang Wenjing , Wang Yawen , Maihemaiti Aziguli , Ren Liang , Lan Tianwei , Zhou Chi , Li Panpan , Wang Pu , Aihemaiti Xianmuseye , Chen Feifei , Xu Tianhong , Xu Jiadai , Liu Peng
Published: February 2023

Background

Significant advances in multiple myeloma (MM) over the past 15 years led to exciting changes in the management of MM patients in China, which in turn brought about the early diagnoses, precise risk stratifications, and improved prognoses.

Methods

We summarized the dynamic changes in the management of newly diagnosed (ND) MM in a national medical center, crossing the old and novel drug era. Demographics, clinical characteristics, first‐line treatment, response rate, and survival were retrospectively collected among NDMMs diagnosed in Zhongshan Hospital Fudan University from January 2007 to October 2021.

Results

Of the 1256 individuals, median age was 64 (range 31–89) with 45.1% patients >65 years. About 63.5% were male, 43.1% were at ISS stage III and 9.9% had light‐chain amyloidosis. Patients with abnormal ratio of free light chain (80.4%), extramedullary disease (EMD, 22.0%), and high‐risk cytogenetic abnormalities (HRCA, 26.8%) were detected by novel detection techniques. The best confirmed ORR was 86.5%, including 39.4% with CR. Short‐ and long‐term PFS and OS rates persistently increased each year along with increasing novel drug applications. Median PFS and OS were 30.9 and 64.7 months. Advanced ISS stage, HRCA, light‐chain amyloidosis and EMD independently predicted an inferior PFS. First‐line ASCT indicated a superior PFS. Advanced ISS stage, elevated serum LDH, HRCA, light‐chain amyloidosis, and receiving PI/IMiD‐based regimen versus PI+IMiD‐based regimen independently indicated a poorer OS.

Conclusions

In brief, we illustrated a dynamic landscape of MM patients in a national medical center. Chinese MM patients evidently benefited from newly introduced techniques and drugs in this field.
Design, Synthesis, and Biological Evaluation of Novel Amyl Ester Tethered Dihydroartemisinin‐Isatin Hybrids as Potent Anti‐Breast Cancer Agents
Authors: Xu Zhi , Zhang Xiaoyan , Liu Jie , Zhao Shijia , Liu Junna , Zhou Wei
Published: February 2023

A series of novel amyl ester tethered dihydroartemisinin‐isatin hybrids 4a–d and 5a–h were designed, synthesized, and evaluated as anti‐breast cancer agents. The synthesized hybrids were preliminarily screened against estrogen receptor‐positive (MCF‐7 and MCF‐7/ADR) and triple‐negative (MDA‐MB‐231 and) breast cancer cell lines. Three hybrids 4a,d and 5e not only were more potent than artemisinin and adriamycin against drug‐resistant MCF‐7/ADR and MDA‐MB‐231/ADR breast cancer cell lines, but also displayed non‐cytotoxicity towards normal MCF‐10 A breast cells, and the SI values were >4.15, indicating their excellent selectivity and safety profiles. Thus, hybrids 4a,d and 5e could act as potential anti‐breast cancer candidates and were worthy of further preclinical evaluations. Moreover, the structure–activity relationships which may facilitate further rational design of more effective candidates were also enriched.
An Anomeric Base‐Tolerant Ester of 8‐Alkynyl‐1‐naphthoate for Gold(I)‐Catalyzed Glycosylation Reaction
Authors: Zhang Xiaojuan , Xu Peng , Zhou Zhengbing , Zhang Yazhou , Yu Biao , Zhu Yugen
Published: February 2023

Comprehensive Summary

Given the extreme complexity and diversity of carbohydrates, efficient approaches to the homogeneous oligosaccharide remain limited. Chemical synthesis represents one of the most reliable methods to access homogeneous samples, which mainly relies on the key glycosylation reaction. Consistent with enormous efforts to develop leaving groups for establishing robust glycosylation protocols, we herein disclose a structurally novel leaving group of 8‐phenylethynyl‐1‐naphthoate that is able to enable efficient glycosylation reactions under the extremely mild condition of gold(I)‐catalysis. Notably, the anomeric naphthoate possesses the unprecedent character of base‐stability in sharp contrast to the conventional ester groups at anomeric position of carbohydrates, which endows high compatibility with a variety of chemical transformations. Furthermore, the present glycosylation protocol with 8‐phenylethynyl‐ 1‐naphthoate as leaving group is able to realize minimally protected glycosylation processes. Mechanistic studies reveal a unique structure of 8‐phenylethynyl‐1‐naphthoate that accounts for the reason for these characteristics.
Towards a synthesized critique of forest‐based ‘carbon‐fix’ strategies
Authors: Vian Jessica Enara , Garvey Brian , Tuohy Paul Gerard
Published: February 2023

This article synthesizes critiques of ‘carbon‐fix’ strategies in the forestry sector to clarify key concerns about reductionist treatments of forests and carbon and to facilitate further debate. It begins by asserting that since climate change mitigation has been placed at the centre of forest governance, forests have been deemed to serve as ‘carbon‐fixing’ devices in ways that can be discerned across three distinct but inter‐related categories: (i) carbon storage devices, (ii) carbon removal devices and (iii) net‐zero bioenergy devices. A transdisciplinary literature review is used to shed light on key concerns relating to the instrumentalisation of forests within each of these categories. By doing so, this article contributes to a deeper understanding of why relegating forests to a ‘carbon‐fix’ function is insufficient to tackle climate change and, rather, poses threats to forest ecosystems and forest‐dependent communities. This review ultimately calls into question the use of forests to delay crucial systemic changes, without diminishing the importance of forest conservation, restoration, governance, as well as technological innovation, in mitigating the ongoing harmful effects of climate change.
Combining bidirectional long short‐term memory and self‐attention mechanism for code search
Authors: Cao Ben , Liu Jianxun
Published: February 2023

With the wide application of deep learning in code search, especially the proposed code search model based on attention mechanism, the accuracy of code search has been greatly improved. However, the attention mechanism only captures the attention weight relationship between two words in the code fragment, without considering the contextual semantic relationship that exists between words in the code fragment, which can help improve the accuracy of code search. To address this problem, this paper proposes a model that combining bidirectional long short‐term memory and self‐attention mechanisms for code search (CBLSAM‐CS). The model first captures the contextual semantic relationship of each word in the code fragment by long‐short term memory network, and then uses the self‐attention mechanism to extract deep‐level features of the sequence. In order to verify the effectiveness of the proposed model, the paper has been conducted an experimental comparison with three other baseline models, CODEnn, CARLCS‐CNN, and SAN‐CS, on the basis of a public dataset containing 18 million code fragments. The experimental results show that the proposed model in this paper achieves 92.24% and 93.55% in mean reciprocal rank value and normalized discounted cumulative gain metrics, respectively, which are better than the baseline model. Therefore, it shows that the CBLSAM‐CS model proposed in this paper can effectively improve the accuracy and efficiency of code search.
Constructing An All‐Natural Bulk Structural Material from Surface‐Charged Bamboo Cellulose Fibers with Enhanced Mechanical and Thermal Properties
Authors: Qin Shizheng , Liu Kun , Wang Yuan , Ren Dayong , Zhang Shaoning , Zhai Yangzhou , Ma Huihuang , Zhou Xiaodong , Huang Fuqiang
Published: February 2023

Bamboo is widely distributed, rapidly regenerable, and incorporates long cellulose fibers, which make it one of the most lightweight and strong natural materials. Processing bamboo into a high‐performance structural material for plastic replacement is highly promising but challenging. In this study, an all‐natural, high‐performance structural material is derived from natural bamboo with superior mechanical and thermal properties that benefit from the introduction of surface charge and further layer‐by‐layer assembly of bamboo cellulose fibers. The obtained modified bamboo fiber plate (MBFP) transcends the constraints of the natural size and anisotropy of bamboo, showing high flexural strength (ca. 179 MPa) and flexural modulus (ca. 12 GPa). Moreover, the product has an extremely low coefficient of thermal expansion (ca. 11.3×10−6 K−1), high thermal stability, and superior fire resistance. The excellent mechanical and thermal properties combined with the efficient and rational manufacturing process make MBFP a powerful plastic alternative for furniture, construction, and automotive industries.
Lymph node metastasis after endoscopic submucosal dissection of a superficial esophageal adenocarcinoma arising from the ectopic gastric mucosa of the cervical esophagus: A case report
Authors: Ito Mamoru , Dobashi Akira , Komori Moe , Sugimura Shun , Aizawa Daisuke , Takahashi Keita , Tanishima Yuichiro , Sumiyama Kazuki
Published: February 2023

Esophageal adenocarcinoma derived from the ectopic gastric mucosa of the cervical esophagus is very rare. Little is known about the efficacy of endoscopic treatment of these superficial lesions. Herein, we report the first case of lymph node metastasis after endoscopic submucosal dissection of a lesion with invasion into the muscularis mucosa. A 46‐year‐old man underwent esophagogastroduodenoscopy during a health checkup. Endoscopy revealed a 10‐mm‐sized nodular and a 5‐mm‐sized depressed lesion within the ectopic gastric mucosa of the cervical esophagus. The biopsy specimen confirmed the presence of adenocarcinoma. The entire ectopic gastric mucosa was resected by endoscopic submucosal dissection, and pathological examination showed invasion of the muscularis mucosa. A follow‐up computed tomography scan revealed lymph node metastasis 12 months post‐treatment. The patient underwent surgical mediastinal lymphadenectomy. The patient has been regularly followed up with a computed tomography scan and endoscopy for 2 years post‐surgery with no evidence of recurrence. Close follow‐up or additional treatment after endoscopic submucosal dissection should be considered and discussed with the patient if invasion into the muscularis mucosa is observed on pathological examination.