bluuebunny/crossref_metadata_2025 huggingface dataset:
Role of Balloon Pulmonary Valvuloplasty in the Management of Pulmonary Stenosis
Authors: Rao P. Syamasundar
Published: November 2021

Although there is definitive evidence for pressure gradient relief both immediately after and at follow-up after balloon pulmonary valvuloplasty (BPV) for pulmonary stenosis (PS), the progression of pulmonary insufficiency (PI) at late follow up emerged as a concern. To address the concern for development of PI during late follow-up, balloon/annuls ratio used for BPV was reduced to 1.2 to 1.25. Recurrence of stenosis was seen in nearly 10% of patients. The causes of recurrence were identified to be balloon/annulus ratio less than 1.2 and immediate post-BPV gradients in excess of 30 mmHg. Recurrent obstructions can be effectively relieved by repeat BPV. The BPV procedure is safe and effective in fetal, neonatal and adult subjects as well. The BPV is also effective in palliating cyanotic congenital heart disease patients with valvar PS. Despite the limitations, BPV is currently considered as therapeutic procedure of choice in the management of congenital PS in both the pediatric and adult populations. BPV provides an excellent alternative to surgical intervention and has become the preferred intervention for initial treatment for PS in neonates, infants, children, adolescents, and adults. Careful follow-up to detect development of significant PI and investigate methods to prevent PI are recommended.
Influence of the parameters of hydrogen nitrogen nitrogen in a glow discharge on tribological and physico-chemical properties of steel 40X
Authors:   Khmelnytsky National University, Stechishina N. , Stechishin M. ,   Khmelnytsky National University, Martynyuk A. ,   Khmelnytsky National University, Lukianyuk N. ,   Khmelnytsky National University, Lyukhovets V. ,   Khmelnytsky National University, Bilyk Yu. ,   Khmelnytsky National University
Published: November 2021

One of the modern and effective methods of hardening metals is nitriding in a glow discharge in ammonia or in an anhydrous medium (nitrogen + argon) - BATR. This paper presents the results of experimental studies comparing the results of tribological and physicochemical properties of hardened surfaces obtained by nitriding with autonomous and interconnected BATR modes. The complex of traditionally fixed values of operating parameters (temperature, composition of the gas mixture, pressure and saturation time) without taking into account energy characteristics (voltage, current density and specific discharge power) significantly reduces the technological capabilities of BATR to achieve the necessary physicochemical properties of metal surfaces specified by conditions exploitation. Taking into account the energy characteristics of BATR, a significant reduction in the energy consumption of the nitriding process is achieved. The energy levels of the main subprocesses are significantly different: the formation of nitrides occurs at low energies, surface sputtering occurs at high voltage values, and nitrogen diffusion occurs at increased current density values. In cases where the energy of the flow is insufficient, either a glow discharge may not occur at all, or with a lack of voltage, the nitride ball on the surface is not sprayed and it acts as a barrier that prevents the diffusion process into the inner layers of the metal, which leads to low physicochemical and, correspondingly, tribological indicators of nitrided balls. The quantitative ratio between them and the required operational properties of the metal, respectively, can be achieved only through an independent combination of the energy and operating characteristics of BATR
Parametric identification of the mathematical model of the functioning of tribosystems in the conditions of boundary lubrication
Authors:   Kharkiv Petro Vasylenko National Technical University of Agriculture, Voitov A.
Published: November 2021

The parametric identification of the tribosystem as an object of modeling the functioning of tribosystems in the conditions of boundary lubrication is performed in the work. Using the analysis of the dimensions of significant factors, expressions are obtained to calculate the gain and time constants. It is established that the coefficient takes into account the degree of influence of the load, sliding speed, tribological characteristics of the lubricating medium on the quality factor of the tribosystem. It is shown that the increase in the coefficient will have a positive effect on the processes inherent in tribosystems during operation. Coefficient – characterizes the magnitude of the change in volumetric wear rate and friction coefficient when changing the magnitude of the load, sliding speed, quality factor of the tribosystem. Coefficient – characterizes the ability of the tribosystem to self-organize when changing the values of the input parameters by rearranging the surface layers of materials from which the triboelements are made during secondary running-in. It is shown that the value of the coefficient is large will contribute to the rapid change in the roughness of the friction surfaces, the restructuring of the structure of the surface layers, the appearance of oxidizing films on the friction surfaces (secondary structures). It is proved that the time constant – this is the time required to change the roughness of the friction surfaces and rearrange the structure of the materials of the surface layers when changing external conditions. Time constant characterizes the time during which there is a stabilization of the temperature gradient by volume of triboelements, taking into account the thermal conductivity of materials when changing external conditions. Time constant characterizes the time during which the tribosystem returns to a steady state of operation after the cessation of the outrageous force, or the time to stabilize the parameters in the new mode of operation. It is proved that the value will be optimal for the process of self-organization. It is shown that one of the factors that can control the value , this is the sliding speed
El mito de la memoria: Aby Warburg y el Atlas Mnemosyne
Authors: Antón-Barco María
Published: November 2021

Aby Warburg es uno de los referentes culturales de estos últimos años; padre de la iconología y creador de la Kulturwissenschaft (Ciencia de la Cultura), es citádo prácticamente en todos los estudios sobre la imagen. Sin embargo, su revival ha venido acompañado de una serie de inexactitudes. El principal objetivo de este artículo es establecer la actualidad de su método de trabajo – si es que puede considerarse que éste realmente fué desarrollado – para el estudio y la crítica de la arquitectura contemporánea. Su forma de recontextualizar las imágenes se muestra especialmente útil a la hora de aproximarse al fragmento panorama arquitectónico actual. Pero antes es necesario aclarar una serie de cuestiones que empañan su figura. Entre ellas, las más relevantes son: la verdadera naturaleza del Atlas Mnemosyne y la relación de su propuesta con la de Walter Benjamin.
Oasis. La casa Loewy en el desierto de Palm Spring
Authors: De Miguel Sergio
Published: November 2021

En los tiempos de la optimista eclosión del Estilo Internacional en América y del comienzo de una nueva domesticidad en California, la peculiar mirada que hiciera el fotógrafo Julius Shulman de la casa Loewy, construida por Albert Frey en el desierto de Palm Springs en 1947, nos permite reconocer las claves de una excepcional pieza de arquitectura.

La simbiótica aportación que hiciera Loewy junto a Frey permite superar ampliamente los rigurosos estándares de lo moderno y consigue exaltar el hedonismo de la cultura del bienestar de la posguerra americana. Atmósfera e intención se unen en una fantástica creación tanto de un espacio como de un tiempo.
Speech delay: some possible factors (a research on 3-6 years old children)
Authors:   Universitas Syah Kuala Banda Aceh, Keumala Meta , Idami Zahratul ,   IAIN Langsa Aceh
Published: November 2021

This qualitative research was to describe the language development of children who indicated speech delay and to find out what factors make these children delay in speech. The data were got from a depth-observation of three children indicating speech delay; 4 and 6 years old children of the first writer’s, and a 3 year- old-child of the writer’s friend’s. The observation was done since the children were indicating speech delay until November 2019. Besides, an open-ended interview was also administered with the mother of the youngest subject. The data were analyzed by using the normal pattern of children’s speech development by Blum and Baron (1997) and main possible factors of speech delay as presented by Shetty (2012). This research found that the subjects experienced speech delay at the ages of 1 year. However, the development of speaking started to increase at the age of 3. Some factors that caused the condition to the subjects were maturation delay, developmental expressive aphasia, bilingualism, and social deprivation.
Grundlagen ethischer Unternehmensverantwortung
Authors: Schüz Mathias
Published: November 2021

Die Ölpest im Golf von Mexiko, die Kernschmelze von Fukushima, die weltweite Finanzkrise sowie zahllose weniger bekannte Schädigungen von Mensch und Natur sind das Ergebnis unverantwortlichen Wirtschaftens. Kann ethisches Verhalten in den Chefetagen solche Auswüchse vermeiden? Wenn ja, wie muss ethische Unternehmensverantwortung beschaffen sein, damit sich Geschäftstätigkeiten nicht nur für die Eigentümer, sondern auch auf Gesellschaft und Natur langfristig positiv auswirken? Welche Hilfestellungen gibt es, um nachhaltig ethische Entscheidungen zu treffen? Zahlreiche Publikationen geben auf solche Fragen teils widersprüchliche Antworten. Die vorliegende Ausgabe der "SML essentials" dient als eine Art Wegweiser, der den Kontext und die Grundbegriffe von Ethik, Verantwortung und Nachhaltigkeit im Rahmen von unternehmerischen Aktivitäten klärt. Darüber hinaus gibt sie Gründe an, weshalb es für Unternehmen sinnvoll ist, sich ihrer vollständigen Verantwortung bewusst zu werden. Erst dann können sie frei entscheiden, ob sie sich selbst zum Vorbild ihrer Branche erheben, den Besten nacheifern oder erst mal abwarten möchten. Sie treffen dann ihre Entscheidung mit all ihren möglichen Konsequenzen bewusst und vermeiden so, zum Spielball zufälliger Reaktionen von Stakeholdern wie z.B. Medien, Investoren oder Kunden zu werden. Viele Unternehmen haben aufgrund schlechter Erfahrungen ihre Aktivitäten bereits erfolgreich auf Nachhaltigkeit oder ethische Verantwortung ausgerichtet. Sie belegen so die Dringlichkeit einer Umorientierung.
Tariqah al-Qawa'id wa at-Tarjamah wa Fa'aliyyatuha fi as-Sahah at-Ta'limiyyah
Authors: Tafida Adam Alhaji
Published: November 2021

This research aims to introduce the Arabic language situation in Jigawa state-Nigeria, also to disclosure the effectiveness of the grammar and translation method in the development of students language skills and to find a suitable method for the development of  language skills. The researcher used the descriptive method to conduct this study, and the most important outcome of the study includes; The grammar and translation method is not appropriate to the objectives of the teaching Arabic language in Jigawa state. The content of the Arabic language in this state is above the students' mental capacity, and does not take into account the individual differences between the students. This study found that the Arabic language teacher in this state, is not aware of the objectives of teaching of Arabic language. There are problems facing students understanding of Arabic language courses, as a result of lack of use of appropriate teaching processes, such as lack of  materials  and the appropriate teaching aids, and resorting to translation more than explanation with acting, and drawing on the blackboard, and so on.
Basic Nutrient Requirements of Beef Cows
Authors: Hersom Matt
Published: November 2021

AN190, an 11-page fact sheet by Matt Hersom, discusses the basic nutrients that are required for production and provides tables indicating diet concentration and daily intake requirements of key nutrients for beef cattle. The information contained in this publication is based upon the recommendations published in the Nutrient Requirements of Beef Cattle (2000). Published by the UF Department of Animal Science, October 2007.
AN190/AN190: Basic Nutrient Requirements of Beef Cows (ufl.edu)
Guia de gestion de plagas para citricos en la Florida 2016: Interpretacion de los enunciados de PPE en las etiquetas de pesticidas
Authors: Nesheim O. Norman , Fishel Frederick M. , Sanchez Tatiana
Published: November 2021

Este documento, PI-16-SPAN (the english version is 2016 Florida Citrus Pest Management Guide: Interpreting PPE Statements on Pesticide Labels (CG031)), es uno de una serie de publicaciones del Departamento de Agronomía, Servicio de Extensión Cooperativa de la Florida, Instituto de Alimentos y Ciencias Agrícolas, Universidad de la Florida (UF/IFAS Extension). Fecha de primera publicación: mayo 2014. Repasado noviembre 2016 y septiembre 2019.
Overseeding Florida Lawns for Winter Color
Authors: Trenholm Laurie E. , Unruh J. Bryan
Published: November 2021

Revised! ENH-14, a 3-page illustrated directory by L.E. Trenholm and J. Bryan Unruh, describes this practice used to provide green winter turf color for Florida lawns — selecting ryegrasses, timing, seedbed preparation, dethatching, seeding, watering, maintenance, and reestablishing permanent grass. Published by the UF Department of Environmental Horticulture, November 2007.
Tropical Foliage Plant Development: Origin of New Cultivars
Authors: Henny Richard J. , Chen Jianjun
Published: November 2021

ENH-1092, a 5-page illustrated fact sheet by R.J. Henny and J. Chen, describes three avenues for new tropical foliage plants to enter the commercial trade — plant acquisition and collection from the wild, selection of natural or induced mutations, and hybridization — and how new introductions are evaluated. Includes references. Published by the UF Department of Environmental Horticulture, January 2008.
ENH1092/EP356: Tropical Foliage Plant Development: Origin of New Cultivars (ufl.edu)
Candidate Species for Florida Aquaculture: Caribbean Spiny Lobster, Panulirus argus
Authors: Miller Christian L. , Ohs Cortney L. , Creswell R. LeRoy
Published: November 2021

FA147, a 5-page fact sheet by Christian L. Miller, Cortney L. Ohs, and R. LeRoy Creswell, introduces this lobster with whip-like antennae for aquaculture in Florida. It gives description and natural history and discusses culture methods, market, and diseases that may affect its aquaculture potential. Includes references and recommended additional reading Published by the UF Department of Fisheries and Aquatic Sciences, September 2007.
FA147/FA147: Candidate Species for Florida Aquaculture: Caribbean Spiny Lobster, Panulirus argus (ufl.edu)
Ask IFAS: Candidate Species for Florida Aquaculture series (ufl.edu)
Florida's Property Tax Reform: Proposed Constitutional Changes
Authors: Clouser Rodney L.
Published: November 2021

FE705, a 6-page fact sheet by Rodney L. Clouser, is part of the Florida’s Property Tax Reform series. It discusses the four core components of the proposed constitutional amendment that will be voted on by Florida residences on January 29, 2008: exemption of tangible personal property, doubling the homestead tax exemption, portability of Save Our Homes differential statewide, and a ten percent cap on the increase in assessments of non-homestead property. Includes references. Published by the UF Department of Food and Resource Economics, December 2007.
Physiological Disorders of Orchids: Oedema
Authors: Cating Robert A. , Palmateer Aaron J. , Stiles Carol M. , Harmon Philip F. , Davison D. A.
Published: November 2021

PP-244, a 3-page illustrated fact sheet by R.A. Cating, A.J. Palmateer, C.M. Stiles, P.F. Harmon, and D.A. Davison, describes this physiological disorder of orchids caused by overwatering, symptoms, diagnosis, and management. Published by the UF Department of Plant Pathology, November 2007.
Weed Management in Apples
Authors: Williamson Jeffrey G.
Published: November 2021

Revised! These 3-4 page fruit and nut fact-sheets by Jeffrey G. Williamson from the Weed Management Guide have been updated. They provide tables of chemical weed control recommendations. Published by UF Department of Horticultural Sciences, November 2007.
HS88/WG014: Weed Management in Pome Fruit (Apple and Pear) (ufl.edu)
Weed Management in Grapes
Authors: Williamson Jeffrey G.
Published: November 2021

Revised! These 3-4 page fruit and nut fact-sheets by Jeffrey G. Williamson from the Weed Management Guide have been updated. They provide tables of chemical weed control recommendations. Published by UF Department of Horticultural Sciences, November 2007.
HS91/WG018: Weed Management in Grape (ufl.edu)
Weed Management in Peaches
Authors: Williamson Jeffrey G.
Published: November 2021

Revised! These 3-4 page fruit and nut fact-sheets by Jeffrey G. Williamson from the Weed Management Guide have been updated. They provide tables of chemical weed control recommendations. Published by UF Department of Horticultural Sciences, November 2007.
HS93/WG020: Weed Management in Stone Fruit Tree Crops (Nectarine, Peach, and Plum) (ufl.edu)
Analisis Kebutuhan Airflow Budget Di Level Extraction Pada Tambang Bawah Tanah Di Area Deep Mill Level Zone (Dmlz) PT. Freeport Indonesia Timika Papua
Authors: Cahyono Yudho Dwi Galih , Sari Avellyn Shinthya , Wambukomo Billi Hanok
Published: November 2021

Freeport Indonesia (PTFI) is a mining company that is an affiliate of Freeport-McMoran Copper & Gold Inc. (FCX) and PT Indonesia Asahan Aluminum (Persero) (Inalum). As of 2019, the Government of Indonesia has taken over 51.23% of shares (41.23% Inalum, 10% Regional Government of Papua). The research methods used in this activity are observational and comparative methods. In analyzing the calculation factors of design budget criteria. The data obtained will be used to compare direct field observation data with monthly report data from the company and equalize it with the air standard for underground mine ventilation based on the Decree of the Minister of Mines and Energy No. 1827 K / 30 / MEM / 2018. Calculation of airflow budget for the equipment used In the calculation and processing of airflow budget data is the R1600 LHD loader, the results of the Utilization Factor for 1 year are obtained by regulation of the Government of PT. Freeport itself uses in accordance with the regulations, namely 0.067 multiplied by 208Kw from the R 1600 LHD tool, obtaining an average 0.302 Maximum 0.482 Minimum 0.033 With a total air supply into the DMLZ mine of 1338 m3 / s, this is very sufficient from the results of the total air demand based on the airflow buget design in accordance where is 1095.6 m3 / s. In underground mining, DMLZ is in accordance with the regulation of the Decree of the Minister of Energy and Mineral Resources of the Republic of Indonesia Number 1827 K / 30 / MEM / 2018
Peningkatan Kompetensi Teknologi Komunikasi untuk Lomba Virtual pada Guru Sekolah Dasar di Surabaya Melalui Pelatihan Editing Video
Authors: Maya Setyoningrum Vinda , Tandyomano Danang , Tsyuroyya Tsyuroyya , Mutiah Mutiah , Miftakhul Huda Anam
Published: November 2021

Melalui pelatihan video editing diharapkan pendidik akan mampu memberikan materi pembelajaran yang menarik dan kreatif bagi peserta didik agar peserta didik lebih focus dan tertarik menerima materi yang disampaikan oleh gurunya. Kualitas pendidik di Kota Surabaya masih perlu ditingkatkan termasuk dalam keterampilan membuat video auidio visual, sehingga diperlukan adanya pelatihan dan bimbingan secara khusus agar tenaga pendidik dapat memiliki skill dalam membuat dan mengedit media pembelajaran berbasis video supaya guru dapat lebih kreatif untuk membuat presentasi materi pembelajaran. Tahapan dalam proses kegiatan pengabdian ini yaitu tahap persiapan,  pelaksanaan, evaluasi, dan pembuatan laporan. Hasil dari kegiatan pengabdian ini yaitu peserta pengabdian mampu menggunakan aplikasi editing video, peserta pengabdian  berhasil membuat suatu produk video pembelajaran yang menarik dan inovatif, peserta pengabdian antusias untuk mengasah kemampuan eiditing video dengan mengikuti kegiatan perlombaan video editing.
Upgrading Keterampilan Jurnalistik dan Literasi Media sebagai Media Exposed Potensi Desa Melalui Pengelolaan Website
Authors: Fahmi Muhammad Hanif , Widayati Sri , Setiyaningsih Lian Agustina
Published: November 2021

Perkembangan teknologi mempengaruhi segala sektor kehidupan, akselerasi penggunaan media berbasis teknologi berdampak pada literasi masyarakat. Masyarakat di pedesaan rentan terhadap iliterasi media. Hal ini merupakan pintu masuk sebuah pemberdayaan masyarakat desa untuk menjadi melek media dan mampu menjadi pengguna media teknologi yang cerdas. Desa harus beradaptasi dengan kemajuan teknologi terutama dalam hal pemanfaatan potensi desa. Karang taruna dan petinggi desa Sitiarjo di Kabpaten Malang belum memiliki kemampuan juralistik dan kemampuan literasi media untuk menyokong pengelolaan web desa. Permasalahan mitra adalah 1) perangkat desa belum memliki kemampuan jurnalistik untuk mengelola website desa. 2) karang taruna tidak memiliki kemampuan literasi media dan jurnalistik untuk membangun kebiasanaan sehat dalam bermedia. Sehingga untuk merespon permasalahan tersebut, dapat dilakukan adalah memberikan keterampilan jurnalistik dan literasi media pada perangkat desa dan karang taruna desa Sitiarjo. Kegiatan ini merupakan pintu masuk untuk menciptakan ekosistem sehat dalam bermedia. Melalui metode pelatihan dan simulasi Iptek kegiatan ini menghasilkan kemampuan membuat konten web dan keterampilan literasi media oleh perangkat desa dan karang taruna desa Sitiarjo. Kedua keterampilan tersebut digunakan untuk pengelolaan web desa yang output akhirnya adalah media expose eksplorasi dan publikasi potensi desa.
Pengaruh Konsumsi Tablet Tambah Darah Terhadap Proses Persalinan dan Kadar Hemoglobin pada Ibu Hamil
Authors: Aditya Martanty , Yoedistira Chresiani Destianita , Rahmawati Yeni
Published: November 2021

Anemia pada kehamilan dapat menyebabkan dekompensasi kordis, persalinan lambat, keguguran, prematur, syok infeksi dan menyumbang meningkatkatnya Angka Kematian Ibu (AKI). Salah satu program pemerintah untuk menurunkan anemia yaitu dengan pemberian tablet tambah darah (TTD) pada ibu hamil minimal 90 tablet selama kehamilan. Namun masih terdapat hasil yang menunjukan rendahnya kepatuhan konsumsi TTD. Penelitian ini bertujuan untuk mengkonfirmasi kembali efektifitas penggunaan TTD terhadap kadar hemoglobin (Hb) dan pengaruh terhadap proses kelahiran secara normal atau Sectio Caesarea (SC). Penelitian ini menggunakan deskriptif analitik dengan pendekatan cross sectional. Pengambilan data dilakukan secara retrospektif, data diambil melalui rekam medis dan dilanjutkan wawancara terstruktur untuk mengkonfirmasi data rekam medis dan serta karakteristik responden. Data yang diperoleh dikumpulkan melalui Lembar Pengumpul Data (LPD). Penelitian ini dilakukan pada ibu melahirkan yang melakukan pemeriksaan di UPT Puskesmas Sumberpucung Kabupaten Malang pada bulan Maret-Mei 2020. Analisis statistic yang digunakan adalah chi square untuk melihat penggunaan TTD dihubungkan dengan proses persalinan normal atau Sectio Caesarrea serta penggunaan TTD dihubungkan dengan kadar Hb. Uji statistic dianalisis menggunakan perangkat lunak sumber terbuka R studio. Didapatkan 52 subyek yang ikut bersedia dalam penelitian ini dimana terdapat 27 responden (51.92%) mengkonsumsi TTD rutin >3 bulan dan 25 responden (48.08%) sebaliknya. Setelah dilakukan analisis didapatkan hasil seluruh pasien yang mengkonsumsi TTD lebih dari tiga bulan melakukan proses persalinan normal (pvalue = 0,000) dan 26 responden memiliki kadar Hb normal (pvalue = 0,000). Dari penelitian ini dapat disimpulkan bahwa konsumsi TTD lebih dari tiga bulan menngurangi risiko kehamilan SC dan juga kejadian anemia.
Pengembangan Sensor Kimia Deteksi Albumin dalam Urin untuk Penyakit Gagal Ginjal Berbasis Cobalt (Co)
Authors: Yoedistira Chresiani Destianita , Hardi Elvin Febriyanti , Monica Eva
Published: November 2021

Penyakit PGK (Penyakit Gagal Ginjal), protein yang hilang melalui urin dapat menyebabkan penurunan kadar albumin atau hipoalbuminemia. Keluarnya albumin melalui urin disebabkan karena adanya penurunan protein yang keluar kedalam filtrat glomerulus. Pengembangan teknologi sensor untuk mendeteksi gagal ginjal. Pada penelitian ini telah dilakukan pembuatan sensor kimia dengan menggunakan reagen cobalt dan amoniak. Pembuatan sensor kimia menggunakan teknik imobilisasi. Teknik imobilisasi  merupakan suatu proses pengikatan molekul reagen cobalt pada bahan pendukung yaitu amoniak sehingga molekul reagen dapat tersebar didalam fase pendukung tersebut secara merata dan homogen. Tahap awal pada pembuatan sensor kimia adalah menentukan kondisi reagen yang optimum. Sensor memiliki hasil optimasi dengan pH optimum pH 7. Memiliki linearitas yang baik pada rentang konsentrasi 150-650 ppm dengan nilai  koefisien korelasi  r = 0,9677. Waktu pakai strip test lebih dari 3 bulan pada suhu ruang. Hasil penelitian validasi metode ini memenuhi persyaratan standar. Pengembangan sensor kimia berbasis cobalt (Co) dapat digunakan untuk mendeteksi PGK (Penyakit Gagal Ginjal) karena telah memenuhi kriteria validasi metode selektivitas, linearitas, akurasi, presisi, LOD dan LOQ sehingga dapat digunakan dalam deteksi albumin dalam urin.
Systematic Review of COVID-19 Treatment and Management
Authors: Tonycheta Chijioke Gospel
Published: November 2021

COVID-19 is an emerging infectious disease, first reported in Wuhan, China. The deadly disease currently known as SARS-CoV-2 can affect everyone regardless of race, gender or age. However, people suffering from underlying medical conditions such as hypertension, diabetes, and other chronic diseases are at the biggest risk for developing more intense symptoms and complications. The global challenge in the containment of COVID-19 has led to a massive death rate and resulted in many economic, social, and health burdens around the world, leading to the question of the dynamic of COVID-19 management treatment. Therefore, this paper aimed to systematically review different past and present studies to develop a possible solution on how COVID-19 can be managed and treated. The articles were searched from five online databases: Science Direct, PubMed/Medline, Web of Science, Embase, and Scopus. The systematic review was guided by the guidelines presented in the preferred reporting items for systematic reviews and meta-analyses (PRISMA) from 2019–2021. Thirteen articles were included after reviewing seventy-two articles. Three hypotheses guided the study; clinical management, telehealth technology, and performance intelligence as an effective way of managing and controlling COVID-19. The study concludes there is no proven treatment for the virus yet, but clinical treatment, telehealth technology, and performance intelligence can effectively manage and control the virus.  It also recommends policymakers should support the development and the implementation of performance intelligence based on the evidence and standardized data available for effective and pandemic resilience health care systems that will address the control and management of the virus.

Keywords: SARS2, SARS-CoV-2, Novel Coronavirus, 2019nCoV, COVID-19.
Connessioni. Intrecci di testi, parole e storie, per ascoltare l’altro e sé stessi
Authors: Dell’Agnola Daniele
Published: November 2021

Nel contributo si descrive un lavoro svolto con allievi tredicenni che hanno cercato di esplorare, ricreare e ricercare i significati del proprio vissuto attraverso il testo letterario e attraverso la scrittura. La relazione tra i giovani lettori e ciò che era loro familiare ha rappresentato il motore di un percorso didattico mosso da una continua conversazione tra l’insegnante, le allieve e gli allievi e i testi. L’itinerario si è rivelato essere un’occasione per riflettere sulle connessioni possibili tra il testo letterario e chi, adolescente, svolge dei compiti di lettura e scrittura.
COMPOSIÇÃO E COMPORTAMENTO DA PAUTA IMPORTADORA DE VARGINHA:
Authors: Flausino de Oliveira Gustavo , Dos Santos Portugal Júnior Pedro , Dos Santos Portugal Nilton
Published: November 2021

O estudo abarca as compras internacionais realizadas pela cidade de Varginha-MG em 2020, ou seja, serão apresentadas informações com a finalidade de identificar o valor importado, volume, origem e características principais dos produtos de acordo com a seção e capítulo da classificação fiscal seguindo a organização da Nomenclatura Comum do Mercosul – NCM. A cidade é a 6ª colocada do estado de Minas Gerais em importações registradas no ano pesquisado, dessa forma, buscou entender os principais dados desse resultado e responder quais características dos produtos importados pela cidade de Varginha-MG em 2020, suas principais origens e valores? A teoria do presente artigo foi construída por meio de pesquisa bibliográfica e documental, trazendo definições de corrente de comércio, balança comercial, importação, classificação fiscal e câmbio. Os dados levantados demonstraram diversas origens, ou seja, países parceiros, bem como uma variedade de produtos, contudo, existe uma concentração maior em países como: Alemanha, Argentina, China, Estados Unidos, México e Rússia, além da importação de produtos nas categorias de produtos químicos orgânicos, produtos farmacêuticos e adubos (fertilizantes), permitindo concluir uma concentração de origens internacionais e frequência de alguns produtos importados.
QUALIDADE DE VIDA NO TRABALHO: ESTUDO COM PROFESSORES DO SUL DE MINAS GERAIS
Authors: Baldim Rabelo Clauber , Camarini Gladis , Querido de Oliveira Chamon Edna Maria
Published: November 2021

As escolas estaduais, municipais e particulares compõem uma parcela significativa de instituições que auxiliam no desenvolvimento local, regional e nacional. Os docentes que atuam nas escolas contribuem com a formação de futuros cidadãos e sua qualidade de vida no trabalho (QVT) interfere na qualidade do ensino. Não obstante, os fatores que interferem na QVT destes docentes também interferem em suas vidas pessoais. Assim, o estudo tem como objetivo investigar a QVT dos docentes da Educação Básica de escolas estaduais, municipais e particulares na região do Sul de Minas Gerais. Trata-se de uma amostra de conveniência constituída por 53 docentes. O instrumento utilizado para a coleta de dados foi o questionário TQWL-42. Os questionários foram distribuídos de forma remota no segundo semestre de 2020. A análise dos dados foi realizada empregando-se software Microsoft Excel. Após estas análises, foi possível observar a satisfação dos docentes do Sul de Minas Gerais acerca de sua QVT em relação a todas das esferas e na maioria dos aspectos do questionário proposto, embora os aspectos avaliados com menor escore demandem uma atenção maior e evidenciem a necessidade de se discutir esta temática.
Quiescin Sulfhydryl Oxidase 2 Overexpression Predicts Poor Prognosis and Tumor Progression in Patients With Colorectal Cancer: A Study Based on Data Mining and Clinical Verification
Authors: Jiang Tao , Zheng Li , Li Xia , Liu Jia , Song Hu , Xu Yixin , Dong Chenhua , Liu Lianyu , Wang Hongyu , Wang Shuai , Wang Renhao , Song Jun
Published: November 2021

Background: As a member of the atypical thiol oxidase family, quiescin sulfhydryl oxidase 2 (QSOX2) has been reported to play an important role in several biological processes, but the expression and function of QSOX2 in colorectal cancer (CRC) remains elusive.

Methods: The difference of QSOX2 expression, and its relationship with clinicopathological features and prognosis in CRC, was analyzed by bioinformatic analysis and validated by clinical CRC specimen cohort. The functional characterization of QSOX2 was detected via in vitro and vivo experiments in CRC cell lines, while the potential signaling pathways were predicted by Gene Set Enrichment Analysis (GSEA).

Results: Our data based on bioinformatical analysis and clinical validation demonstrated that the expression of QSOX2 in CRC tissues was significantly upregulated. Additionally, the chi-square test, logistic regression analysis, and Fisher’s exact test showed that QSOX2 overexpression was significantly correlated with advanced clinicopathological parameters, such as pathological stage and lymph node metastasis. The Kaplan–Meier curves and univariate Cox regression model showed that QSOX2 overexpression predicts poor overall survival (OS) and disease-free survival (DFS) in CRC patients. More importantly, multivariate Cox regression model showed that QSOX2 overexpression could serve as an independent factor for CRC patients. In vitro and vivo data showed that the proliferation and metastasis ability of CRC cells were suppressed on condition of QSOX2 inhibition. In addition, GSEA showed that the QSOX2 high expression phenotype has enriched multiple potential cancer-related signaling pathways.

Conclusion: QSOX2 overexpression is strongly associated with malignant progression and poor oncological outcomes in CRC. QSOX2 might act as a novel biomarker for prognosis prediction and a new target for biotherapy in CRC.
Comprehensive Pan-Cancer Analysis of the Prognostic and Immunological Roles of the METTL3/lncRNA-SNHG1/miRNA-140-3p/UBE2C Axis
Authors: Jiang Xiulin , Yuan Yixiao , Tang Lin , Wang Juan , Liu Qianqian , Zou Xiaolan , Duan Lincan
Published: November 2021

Growing evidence has demonstrated that UBE2C plays a critical role in cancer progression, but there is no study focusing on the prognosis, upstream regulation mechanism, and immunological roles of UBE2C across diverse tumor types. In this study, we found that UBE2C was elevated in this human pan-cancer analysis, and high expression of UBE2C was correlated with poor prognosis. In addition, UBE2C expression was markedly associated with tumor mutation burden (TMB), microsatellite instability (MSI), immune cell infiltration, and diverse drug sensitivities. Finally, we showed that the METTL3/SNHG1/miRNA-140-3p axis could potentially regulate UBE2C expression. N(6)-Methyladenosine (m6A) modifications improved the stability of methylated SNHG1 transcripts by decreasing the rate of RNA degradation, which lead to upregulation of SNHG1 in non-small cell lung cancer (NSCLC). In vitro functional experiments showed that SNHG1, as a competing endogenous RNA, sponges miR-140-3p to increase UBE2C expression in NSCLC cell lines. Our study elucidates the clinical importance and regulatory mechanism of the METTL3/SNHG1/miRNA-140-3p/UBE2C axis in NSCLC and provides a prognostic indicator, as well as a promising therapeutic target for patients with NSCLC.
Clonorchis sinensis Granulin Promotes Malignant Transformation of Hepatocyte Through EGFR-Mediated RAS/MAPK/ERK and PI3K/Akt Signaling Pathways
Authors: Wang Caiqin , He Qing , Yin Yingxuan , Wu Yinjuan , Li Xuerong
Published: November 2021

The biological functions of growth factor, such as granulins, have been explored in parasites, and we elucidated that Clonorchis sinensis granulin (CsGRN) promoted the metastasis of hepatocellular carcinoma in our previous study. However, it is still unclear for the malignant transformation role of CsGRN in normal human hepatocytes. In this study, by transfecting pEGFP-C1-CsGRN eukaryotic expression plasmid, a cell line with stable overexpression of CsGRN in normal hepatocyte (LO2-GRN cells) was constructed. The effects on cell proliferation were detected by carrying out cell counting kit-8 (CCK8) assay and colony formation assay. Additionally, we conducted flow cytometry analysis to determine whether the proliferation of CsGRN was due to cell cycle arrest. Subsequently, the migration ability and the invasion ability of LO2-GRN cells were evaluated through wound-healing assay and transwell assay. Meanwhile, the levels of the markers of RAS/MAPK/ERK and PI3K/Akt signaling pathways activation in LO2-GRN cells were assessed by quantitative RT-PCR and Western blot. Our results indicated that CsGRN promoted the proliferation of LO2 cells by regulating the expression of cell-cycle-related genes. Moreover, the overexpression of CsGRN regulates malignant metastasis of liver cells by inducing the upregulation of epithelial–mesenchymal transition (EMT) marker proteins. Furthermore, both mRNA and protein expression levels of p-EGFR, RAS, p-ERK, p-AKT, p-PI3K, and p-braf have been enhanced by CsGRN. These results showed that CsGRN promoted the malignant transformation of hepatocytes by regulating epidermal growth factor receptor (EGFR)-mediated RAS/MAPK/ERK and PI3K/Akt signaling pathways, which suggested that CsGRN could serve as a novel oncoprotein during Clonorchis sinensis–associated malignant transformation of hepatocytes.
The Transcriptional Differences of Avian CD4+CD8+ Double-Positive T Cells and CD8+ T Cells From Peripheral Blood of ALV-J Infected Chickens Revealed by Smart-Seq2
Authors: Dai Manman , Zhao Li , Li Ziwei , Li Xiaobo , You Bowen , Zhu Sufang , Liao Ming
Published: November 2021

It is well known that chicken CD8+ T cell response is vital to clearing viral infections. However, the differences between T cell subsets expressing CD8 receptors in chicken peripheral blood mononuclear cells (PBMCs) have not been compared. Herein, we used Smart-Seq2 scRNA-seq technology to characterize the difference of chicken CD8high+, CD8high αα+, CD8high αβ+, CD8medium+, and CD4+CD8low+ T cell subsets from PBMCs of avian leukosis virus subgroup J (ALV-J)-infected chickens. Weighted gene co-expression network analysis (WGCNA) and Trend analysis revealed that genes enriched in the “Cytokine–cytokine receptor interaction” pathway were most highly expressed in the CD8high αα+ T cell population, especially T cell activation or response-related genes including CD40LG, IL2RA, IL2RB, IL17A, IL1R1, TNFRSF25, and TNFRSF11, suggesting that CD8high αα+ T cells rather than other CD8 subpopulations were more responsive to ALV-J infections. On the other hand, genes involved in the “FoxO signaling pathway” and “TGF-beta signaling pathway” were most highly expressed in the CD4+CD8low+ (CD8low+) T cell population and the function of CD4+CD8low+ T cells may play roles in negatively regulating the functions of T cells based on the high expression of CCND1, ROCK1, FOXO1, FOXO3, TNFRSF18, and TNFRSF21. The selected gene expressions in CD8+ T cells and CD4+CD8low+ double-positive T cells confirmed by qRT-PCR matched the Smart-Seq2 data, indicating the reliability of the smart-seq results. The high expressions of Granzyme K, Granzyme A, and CCL5 indicated the positive response of CD8+ T cells. Conversely, CD4+CD8+ T cells may have the suppressor activity based on the low expression of activation molecules but high expression of T cell activity suppressor genes. These findings verified the heterogeneity and transcriptional differences of T cells expressing CD8 receptors in chicken PBMCs.
Rapid Detection of Cysticercus cellulosae by an Up-Converting Phosphor Technology-Based Lateral-Flow Assay
Authors: Zhang Dejia , Qi Yu , Cui Yaxuan , Song Weiyi , Wang Xinrui , Liu Mingyuan , Cai Xuepeng , Luo Xuenong , Liu Xiaolei , Sun Shumin
Published: November 2021

Cysticercosis is a neglected tropical disease caused by the larvae of Taenia solium in pigs and humans. The current diagnosis of porcine cysticercosis is difficult, and traditional pathological tests cannot meet the needs of detection. This study established a UPT-LF assay for the detection of Cysticercus cellulosae. UCP particles were bound to two antigens, TSOL18 and GP50; samples were captured, and the signal from the UCP particles was converted into a detectable signal for analysis using a biosensor. Compared to ELISA, UPT-LF has higher sensitivity and specificity, with a sensitivity of 93.59% and 97.44%, respectively, in the case of TSOL18 and GP50 antigens and a specificity of 100% for both. Given its rapidness, small volume, high sensitivity and specificity, and good stability and reproducibility, this method could be used in the diagnosis of cysticercosis.
Advances in Biomarkers for Detecting Early Cancer Treatment-Related Cardiac Dysfunction
Authors: Xiao Huiyu , Wang Xiaojie , Li Shuang , Liu Ying , Cui Yijie , Deng Xiaoqin
Published: November 2021

With the gradual prolongation of the overall survival of cancer patients, the cardiovascular toxicity associated with oncology drug therapy and radiotherapy has attracted increasing attention. At present, the main methods to identify early cancer treatment-related cardiac dysfunction (CTRCD) include imaging examination and blood biomarkers. In this review, we will summarize the research progress of subclinical CTRCD-related blood biomarkers in detail. At present, common tumor therapies that cause CTRCD include: (1) Chemotherapy—The CTRCD induced by chemotherapy drugs represented by anthracycline showed a dose-dependent characteristic and most of the myocardial damage is irreversible. (2) Targeted therapy—Cardiovascular injury caused by molecular-targeted therapy drugs such as trastuzumab can be partially or completely alleviated via timely intervention. (3) Immunotherapy—Patients developed severe left ventricular dysfunction who received immune checkpoint inhibitors have been reported. (4) Radiotherapy—CTRCD induced by radiotherapy has been shown to be significantly associated with cardiac radiation dose and radiation volume. Numerous reports have shown that elevated troponin and B-type natriuretic peptide after cancer treatment are significantly associated with heart failure and asymptomatic left ventricular dysfunction. In recent years, a few emerging subclinical CTRCD potential biomarkers have attracted attention. C-reactive protein and ST2 have been shown to be associated with CTRCD after chemotherapy and radiation. Galectin-3, myeloperoxidas, placental growth factor, growth differentiation factor 15 and microRNAs have potential value in predicting CTRCD. In this review, we will summarize CTRCD caused by various tumor therapies from the perspective of cardio-oncology, and focus on the latest research progress of subclinical CTRCD biomarkers.
Maslinic Acid Attenuates Ischemia/Reperfusion Injury-Induced Myocardial Inflammation and Apoptosis by Regulating HMGB1-TLR4 Axis
Authors: Li Qi , Xu Mengping , Li Zhuqing , Li Tingting , Wang Yilin , Chen Qiao , Wang Yanxin , Feng Jiaxin , Yin Xuemei , Lu Chengzhi
Published: November 2021

Aims: The inflammatory response and apoptosis are the major pathological features of myocardial ischemia/reperfusion injury (MI/RI). Maslinic acid (MA), a natural pentacyclic triterpene with various bioactivities, plays critical roles in the multiple cellular biological processes, but its protective effects on the pathophysiological processes of MI/RI have not been extensively investigated. Our study aimed to determine whether MA treatment alleviate ischemia/reperfusion (I/R)-induced myocardial inflammation and apoptosis both in vitro and in vivo, and further reveal the underlying mechanisms.

Methods and results: An MI/RI rat model was successfully established by ligating the left anterior descending coronary artery and H9c2 cells were exposed to hypoxia/reoxygenation (H/R) to mimic I/R injury. In addition, prior to H/R stimulation or myocardial I/R operation, the H9c2 cells or rats were treated with varying concentrations of MA or vehicle for 24 h and two consecutive days, respectively. In this study, our results showed that MA could obviously increase the cell viability and decrease the cardiac enzymes release after H/R in vitro. MA could significantly improve the H/R-induced cardiomyocyte injury and I/R-induced myocardial injury in a dose-dependent manner. Moreover, MA suppressed the expression of inflammatory cytokines (tumor necrosis factor alpha [TNF-α, interleukin-1β [IL-1β and interleukin-6 [IL-6]) and the expressions of apoptosis-related proteins (cleaved caspase-3 and Bax) as well as increased the levels of anti-apoptotic protein Bcl-2 expression both in vitro and in vivo. Mechanistically, MA significantly inhibited nuclear translocation of nuclear factor-κB (NF-κB) p65 after H/R via regulating high mobility group box 1 (HMGB1)/toll-like receptor 4 (TLR4) axis.

Conclusion: Taken together, MA treatment may alleviate MI/RI by suppressing both the inflammation and apoptosis in a dose-dependent manner, and the cardioprotective effect of MA may be partly attributable to the inactivation of HMGB1/TLR4/NF-κB pathway, which offers a new therapeutic strategy for MI/RI.
Increased ApoE Expression in Follicular Fluid and the ApoE Genotype Are Associated With Endometriosis in Chinese Women
Authors: Liu Ya-Jing , Xing Fen , Zong Kai , Wang Meng-Yao , Ji Dong-Mei , Zhao Yu-Hang , Xia Yun-He , Wang An , Shi Ling-Ge , Ding Si-Min , Wei Zhao-Lian , Qiao Jin-Ping , Du Xin , Cao Yun-Xia
Published: November 2021

More than 10% of women suffer from endometriosis (EMT) during their reproductive years. EMT can cause pain and infertility and requires further study from multiple perspectives. Previous reports have indicated that an increase inapolipoprotein E (ApoE) may be associated with a lower number of retrieved mature oocytes in older women, and an association between ApoE and spontaneous pregnancy loss may exist in patients with EMT. The purpose of this study was to investigate the existence of an increase in ApoE in follicular fluid (FF) and the possible relationship between ApoE and EMT in Chinese women. In the current study, 217 Chinese women (111 control subjects and 106 EMT patients) were included. The ApoE genotypes were identified by Sanger sequencing. We found that ApoE expression in FF was higher in patients with EMT than in the control group. In addition, a significant difference in ApoE4 carriers (ϵ3/ϵ4, ϵ4/ϵ4) was found between the control subjects and the patients with EMT. Furthermore, a nonparametric test revealed significant differences in the numbers of blastocysts and high-quality blastocysts, but not the hormone levels of FSH, LH, and E2, between the two groups. We also established a multifactor (BMI, high-quality blastocysts, and ϵ4) prediction model with good sensitivity for identifying patients who may suffer from EMT. Our results demonstrate that ApoE expression in FF is increased in EMT, the ApoE-ϵ4 allele is significantly linked to EMT, and a combined analysis of three factors (BMI, high-quality blastocysts, and ϵ4) could be used as a predictor of EMT.
Intraspecies Genomic Divergence of a Fig Wasp Species Is Due to Geographical Barrier and Adaptation
Authors: Xu Xun , Wang Bao-Sheng , Yu Hui
Published: November 2021

Understanding how intraspecies divergence results in speciation has great importance for our knowledge of evolutionary biology. Here we applied population genomics approaches to a fig wasp species (Valisia javana complex sp 1) to reveal its intraspecies differentiation and the underlying evolutionary dynamics. With re-sequencing data, we prove the Hainan Island population (DA) of sp1 genetically differ from the continental ones, then reveal the differed divergence pattern. DA has reduced SNP diversity but a higher proportion of population-specific structural variations (SVs), implying a restricted gene exchange. Based on SNPs, 32 differentiated islands containing 204 genes were detected, along with 1,532 population-specific SVs of DA overlapping 4,141 genes. The gene ontology (GO) enrichment analysis performed on differentiated islands linked to three significant GO terms on a basic metabolism process, with most of the genes failing to enrich. In contrast, population-specific SVs contributed more to the adaptation than the SNPs by linking to 59 terms that are crucial for wasp speciation, such as host reorganization and development regulation. In addition, the generalized dissimilarity modeling confirms the importance of environment difference on the genetic divergence within sp1. Hence, we assume the genetic divergence between DA and the continent due to not only the strait as a geographic barrier, but also adaptation. We reconstruct the demographic history within sp1. DA shares a similar population history with the nearby continental population, suggesting an incomplete divergence. Summarily, our results reveal how geographic barriers and adaptation both influence the genetic divergence at population-level, thereby increasing our knowledge on the potential speciation of non-model organisms.