bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Islamic Governance Score, Leverage, Ukuran Perusahaan, dan Ukuran Dewan Komisaris Terhadap Kesehatan Finansial Bank Umum Syariah (Studi Empiris di BEI Periode 2013 Sampai 2016)
Authors: Faizah Yuniar Laeli Nur , Hartiyah Sri
Published: October 2018

This study aims to analyze the effect of capital adequacy ratio, return on assets, non performing financing, operating expenses to operating revenues, financing to deposit ratio, third party fund, nisbah, and number of office to the market share of Islamic banking in Indonesia.

Population in this study are quarterly financial statements of  Sharia Commercial Banks and Sharia Business Units in Indonesia registered in BEI for the period December 2013 to 2016. The sampling technique in this study was conducted by purposive sampling method, so that 12 banks were obtained as research samples. The analytical method used in this study is multiple linear regression with the help of SPSS statistics.

The influence of BUS does not affect the financial health of BUS, leverage does not negatively affect the financial health of BUS, the size of the company does not have a positive effect on the financial health of BUS, the size of the board of directors has no effect on the financial health of BUS.

 

Keywords : Financial health of Islamic commercial banks, Islamic governance score, leverage, company size, and the size of the board of commissioners
Analisis Pengaruh Modal Usaha, Kreatifitas dan Daya Saing Terhadap Pengembangan UMKM (Studi Kasus pada Bengkel Las di Kabupaten Wonosobo)
Authors: Takhim Muhamad , Meftahudin Meftahudin
Published: October 2018

Penelitian ini bertujuan untuk mengetahui seberapa besar pengaruh modal usaha, kterativitas dan daya saing terhadap pengembangan UMKM Populasi yang digunakan dalam penelitian ini adalah pemilik bengkel las di Kabupaten Wonosobo. Sampel pada penelitian ini sebanyak 50 responden dan teknik yang digunakan adalah total sampling. Data – data yang telah memenuhi uji validitas, uji reliabilitas dan uji asumsi klasik diolah menghasilkan persamaan regresi sebagai berikut Y = 2,415 X1 + 0,376 X2 + 0,250 X3. Y adalah variabel pengembangan UMKM, X1 adalah variabel modal usaha, X2 adalah variabel kreativitas dan X3 adalah variabel daya saing. Pengujian hipootesis menggunakan uji t menunjukkan bahwa ketiga variabel independen modal usaha, krativitas dan daya saing berpengaruh signifikan terhadap variabel dependen pengembangan umkm, Kemudian melalui uji f dapat diketahui bahwa ketiga variabel independen layak untuk menguji variabel dependen pengembangan umkm. Angka R Square sebesar 0,773 menunjukkan bahwa 73,3% variabel pengembangan UMKM dapat dijelaskan oleh ketiga variabel independen dalam persamaan regresi. Sedangkan sisanya sebesar 22,7% dijelaskan oleh variabel lain diluar ketiga variabel yang digunakan dalam penelitian ini.

 

Kata Kunci : pengembangan umkm, modal usaha, kreativitas dan daya saing
Activities of the Central Propaganda Committee’s Department for South Vietnam in the 1965-1968 period
Authors: Do Bien Van
Published: October 2018

In the most difficult moments of the war against America, the Central Propaganda Committee’s Department for South Vietnam undertook the mission of “fire holding” and “heat transferring” to the battle of the South of Vietnam. From the requirement of the resistance, the Central Propaganda Committee’s Department for South Vietnam organized many activities on propaganda, training, personnel organization and political fighting movement for the Southerners. The paper presents the activities and achievements in the field of propaganda of the Central Propaganda Committee’s Department for South Vietnam in the 1965-1968 period, and at the same time, confirms the important contribution of this work in the resistance war against American.
The whale worshiping festival in the An Thủy fishing community (Ba Tri district - Ben Tre province)
Authors: Duong Loc Hoang
Published: October 2018

The paper introduces, analyzes as well as finds out values and typical features of the whale worshiping festival from An Thuy fishing community (in Ba Tri district, Ben Tre Province). The basis of research used to complete the paper are theories of functionalism and structuralism combining with field study methods belonging to the ethnology and anthropology. My research demonstrates the whale worshiping festival organized by the fishing community living here which reflects the local people’s praying the Southern Ocean God who will save and support them. The festival shows the community connection and cultural transformation for following generations.
The role of the Vietnam securities market as a capital mobilization channel
Authors: To Truc Thi Thanh , Nguyen Hien Thi Diem
Published: October 2018

This paper attempts to evaluate the role of Vietnam securities market as a capital mobilization channel for the economy through the activities on the primary market in the period between 2005 and 2013, focusing on Hanoi Stock Exchange. A summary of the establishment, development and operations of the secondary market in the period from 2005 to 2013 with information of size, liquidity of both stock and bond markets is also included. Through the analysis the efficiency of capital mobilization on the primary market, we find that the securities market is yet to become an efficient capital mobilization channel for companies. Therefore, in order for the securities market to develop safely and become an efficient capital mobilization channel, authorities need to have promoting policies, enhance the quality of market participants as well as the governance and operations of listed companies.
La cuestión de la regeneración de la raza en el discurso educativo del laicismo
Authors: Terán Najas Rosmarie
Published: October 2018

La estructura de la educación primaria laica y los imaginarios sobre la infancia colaboraron para no transformar de manera sustancial los parámetros de la segmentación social. Aunque la historiografía favorable a resaltar las bondades del liberalismo no lo mencione, no se puede dejar de admitir que un enfoque discriminativo de las diferencias socio-culturales estuvo presente en el discurso liberal. Pese a que la misión civilizatoria asignada a la educación tenía que ver con la formación de ciudadanos progresistas y modernos.
Glutathione Peroxidase1 Gene Polymorphism (GPx1 Pro198Leu) in Association with Blighted Ovum
Authors: Moshtaghi Asiyeh , Sariri Reyhaneh , Vaziri Hamidreza , Shayegan Horiyeh
Published: October 2018

Objective: To evaluate salivary GPx-1 gene polymorphism in pregnant

women suffering from blighted ovum.

Method: In this case-control study, 34 blighted ovum patients and

34 healthy controls were studied. Genomic DNA was extracted from

the saliva. The genotypes were determined by restriction fragment

length polymorphism (RFLP-PCR) technique. Mad Calc (version

12.1) was used for statistical analysis.

Result: The frequency of CC, CT, and TT genotypes of GPx-1 gene

were 41%, 44% and 14%, respectively in blighted ovum patients

and in healthy volunteers were 44%, 47%, and 8.82-9%, respectively.

After statistical analysis, the study showed no significant association

between this polymorphism and blighted ovum (with p =

0.63).

Conclusion: These results indicated no significant association between

GPx-1 (Pro198Leu) polymorphism and blighted ovum. However,

further research is required to clarify the role of gene polymorphism

in blighted ovum.

[Indones J Obstet Gynecol 2016; 1: 15-18]

Keywords: abortion, blighted ovum, glutathione peroxidase-1, GPx-

1, RFLP-PCR
Impact of Ethinyl Estradiol to Human Telomerase Reverse Transcriptase Activity on Complete Hydatidiform Mole Culture
Authors: Nurseta Tatit , Wijasa Arsana , Sitompul Barlian
Published: October 2018

Objective: To prove the effect of ethinyl estradiol as an activator on

human Telomerase Reverse Transcriptase (hTERT).

Method: The experimental study was conducted in vitro by using

culture of complete hydatidiform mole trophoblast cell. We exposed

the culture to ethinyl estradiol in varied doses and measured the

concentration of hTERT through RT-PCR quantitative. There were

40 specimens as control group and 20 specimens exposed to ethinyl

estradiol in different doses (10, 20, 40 and 80 mcg) as experimental

group. The activity of hTERT was measured by RT-PCR and the

concentration of it was assessed by ELISA. We analyzed the variables

using ANOVA, Turkey post hoc and Pearson correlation test.

Result: In control group, the concentration of hTERT was not detected.

Meanwhile, the concentration among different doses of

ethynil estradiol (10, 20, 40, 80 mcg) was 113,117.5; 114,507.6;

102,193.9; 127.546.1 amoles/ml, respectively. Among experimental

group, they were significantly different both using F test (ANOVA)

(p=0.001) and Turkey post hoc test (p=0.005). The correlation

among group was 0.84 which meant higher level of ethinyl estradiol

was correlated with higher activity of hTERT.

Conclusion: Ethinyl estradiol impacts to the increase of hTERT activity

on complete hydatidiform mole cell culture.

[Indones J Obstet Gynecol 2016; 4-2: 93-96]

Keywords: complete hydatidiform mole, ethinyl estradiol, human

Telomerase Reverse Transcriptase (hTERT)
Mesothelin versus Ca125 in Screening the Ovarian Malignancy
Authors: Jayasaputra Meliana , Wagey Freddy W , Rarung Max R
Published: October 2018

Objective: To determine the sensitivity and specificity of mesothelin

compared with Ca-125 as a tumor marker in predicting ovarian malignancy.

Method: The cross sectional study design with diagnostic tests was

conducted in 30 samples of patients undergoing elective laparotomy

due to ovarian tumor. We compared the sensitivity and specificity

between mesothelin and Ca-125, then the data were analyzed using

SPSS software version 22.0.

Result: According to the ROC curve analysis, optimal sensitivity and

specificity value of mesothelin was 63.2% and 54.5% at a cut-off

point of 0.45 pg/ml; or 42.1% and 72.7% at a cut-off point of 0.55

pg/ml. While the value of both optimal sensitivity and specificity of

Ca-125 was 73.7% and 63.6% at a cut-off point of 46.63 U/ml.

Conclusion: Mesothelin and Ca-125 are not different significantly

for the AUC value of 50%. Due to higher sensitivity and specificity of

Ca-125 than mesothelin, Ca-125 is still used as tumor marker for

screening the ovarian malignancy.

[Indones J Obstet Gynecol 2016; 4-2: 107-110]

Keywords: Ca-125, mesothelin, ovarian malignancy
Effect of Rectal Misoprostol to Blood Loss at High Risk Pregnancy
Authors: Daniel Liando Daniel Liando , Manoe IMS Murah , Moeljono Eddy R
Published: October 2018

Objective: To compare the effectiveness of rectal misoprostol administration

to the amount of blood loss in 4th stage of labor at high

risk pregnancy.

Method: We recruited all pregnant women with high risk criteria including

anemia, age  35 years old, or the number of pregnancies

 4. Women would deliver appropriate to standard procedure of

normal delivery. After that, we gave 400-mcg tablet of misoprostol

rectally in treatment group. To count the amount of blood loss

during 4th stage of labor, we put the underpad.

Result: The amount of blood loss in 4th stage of labor in the treatment

group was 201.1 (SD 80.3) ml less than the control group

(285.9 (SD 93.2) ml). The result showed that the administration of

400-mcg misoprostol tablet rectally immediately after the birth of

the placenta at high risk pregnancy impacted significantly to reduce

the amount of blood loss in 4th stage of labor (p
A Simple Ultrasound Examination as Diagnostic Tool for Malignant Ovarian Tumor
Authors: Wigin Christin , Andrijono Andrijono
Published: October 2018

Objective: To know the diagnostic value of simple ultrasound examination to detect malignant ovarian tumor.

Method: This study used cross-sectional design in gynecology outpatientclinic at Dr. Cipto Mangunkusumo Hospital. We recruited the patients with ovarian tumor undergoing surgery between March

and July 2015. Samples were taken using consecutive sampling.

Analysis was done using Chi-square test and logistic regression to

find the relationship between ultrasound morphologic patterns with

histopathologic findings, where the significant relationship was p

value less than 0.05. Furthermore, a model derived from logistic regression was made to calculate the probability having ovarian malignancy.

Result: There were 80 subjects which 58 subjects (72.5%) had

benign tumor and 22 subjects (27.5%) had malignant tumor. Ultrasound examination result using  2 morphologic patterns gave malignant result in 53.8% subjects with the sensitivity of 100%, specificity of 82.8%, positive predictive value of 68.8%, and negative predictive value of 100%. The most important patterns were irregular

internal cyst wall, multilocular, presence of papillary projection, and

presence of solid component. The probability of subject having ovarian

malignancy with  3 morphologic patterns was more than

88.9%.

Conclusion: Simple ultrasound examination can be used to detect

malignant ovarian tumor.

[Indones J Obstet Gynecol 2016; 4-4: 222-226]

Keywords: diagnostic, histopathology, morphology pattern; ovarian

tumor; ultrasonography
index
Authors: INAJOG INAJOG
Published: October 2018

N/A
Application of Data Science Technology on Research of Circulatory System Disease Prediction Based on a Prospective Cohort
Authors: Tang Haijing , Chen Guo , Kang Yu , Yang Xu
Published: October 2018

Chronic diseases represented by circulatory diseases have gradually become the main types of diseases affecting the health of our population. Establishing a circulatory system disease prediction model to predict the occurrence of diseases and controlling them is of great significance to the health of our population. This article is based on the prospective population cohort data of chronic diseases in China, based on the existing medical cohort studies, the Kaplan–Meier method was used for feature selection, and the traditional medical analysis model represented by the Cox proportional hazards model was used and introduced. Support vector machine research methods in machine learning establish circulatory system disease prediction models. This paper also attempts to introduce the proportion of the explanation variation (PEV) and the shrinkage factor to improve the Cox proportional hazards model; and the use of Particle Swarm Optimization (PSO) algorithm to optimize the parameters of SVM model. Finally, the experimental verification of the above prediction models is carried out. This paper uses the model training time, Accuracy rate(ACC), the area under curve (AUC)of the Receiver Operator Characteristic curve (ROC) and other forecasting indicators. The experimental results show that the PSO-SVM-CSDPC disease prediction model and the S-Cox-CSDPC circulation system disease prediction model have the advantages of fast model solving speed, accurate prediction results and strong generalization ability, which are helpful for the intervention and control of chronic diseases.
From Reception to Invention: The Arrival of Concrete to Iceland and the Rhetoric of Guðmundur Hannesson
Authors: Nannini Sofia
Published: October 2018

The quick modernisation of Iceland, which took place rapidly from the first decades of the 20th century onwards, brought not only fishing trawlers and cars into the country. Among all the techniques of modernity, steinsteypa [concrete] was to become the key material that changed the built landscape of the island and was soon adopted by the first Icelandic architects, such as Rögnvaldur Ólafsson (1874–1914) and Guðjón Samúelsson (1887–1950). Interestingly, the main supporter of this material was Guðmundur Hannesson (1866–1946), a medical doctor and town planning enthusiast who wrote several articles and even a guidebook published in 1921, Steinsteypa. Leiðarvísir fyrir alþýðu og viðvaninga [Concrete: A Guidebook for Common People and Beginners]. In a country that was seeking an architectural self-representation, he understood the technical and formal possibilities that concrete could offer. By analysing his articles and publications, this essay aims to discuss the rhetoric of Guðmundur Hannesson and his role in writing an Icelandic chapter of the history of concrete, from its early stage of unmodern trial-and-error to the definition of a modern Icelandic architecture.
Water Driven Soft Actuator
Authors: Matsumoto Mitsuharu
Published: October 2018

In this paper, a water driven soft actuator is introduced. Soft actuators driven by various external stimuli, such as air pressure, temperature, pH, electric field, and light have been reported in the past. Although they are very attractive, they often require hard external devices for driving and the response speeds are often slow. The developed water driven actuator was with sodium polyacrylate wrapped by stretchable meshed nylon. Through some experiments, it was confirmed that swell and shrink phenomena of the developed device occur depending on the fluid flow. The phenomena could be found when adequate quantity of sodium polyacrylate was inside of the nylon. The amount of sodium polyacrylate that is required for the phenomenon was investigated. Through the experiments, it was confirmed that the displacement and the response speed of the swell and shrink were large and fast, respectively, in spite of its simple implementation.
A Recombinant Snake Cathelicidin Derivative Peptide: Antibiofilm Properties and Expression in Escherichia coli
Authors: Tajbakhsh Mercedeh , Akhavan Maziar Mohammad , Fallah Fatemeh , Karimi Abdollah
Published: October 2018

The emergence of antimicrobial resistance among pathogenic microorganisms has been led to an urgent need for antibiotic alternatives. Antimicrobial peptides (AMPs) have been introduced as promising therapeutic agents because of their remarkable potentials. A new modified cathelicidin-BF peptide (Cath-A) with 34 amino acid sequences, represents the potential antimicrobial effects against methicillin-resistant Staphylococcus aureus (MRSA) with slight hemolytic and cytotoxic activities on eukaryotic cells. In this study, the effects of Cath-A on Acinetobacter baumannii, and Pseudomonas aeruginosa isolated from medical instruments were studied. Cath-A inhibited the growth of bacterial cells in the range of 8–16 μg/mL and 16-≥256 μg/mL for A. baumannii and P. aeruginosa, respectively. The peptide significantly removed the established biofilms. To display a representative approach for the cost-effective constructions of peptides, the recombinant Cath-A was cloned in the expression vector pET-32a(+) and transformed to Escherichia coli BL21. The peptide was expressed with a thioredoxin (Trx) sequence in optimum conditions. The recombinant peptide was purified with a Ni2+ affinity chromatography and the mature peptide was released after removing the Trx fusion protein with enterokinase. The final concentration of the partially purified peptide was 17.6 mg/L of a bacterial culture which exhibited antimicrobial activities. The current expression and purification method displayed a fast and effective system to finally produce active Cath-A for further in-vitro study usage.
Druggable Nucleolin Identifies Breast Tumours Associated with Poor Prognosis That Exhibit Different Biological Processes
Authors: Nguyen Van Long Flora , Lardy-Cleaud Audrey , Bray Susan , Chabaud Sylvie , Dubois Thierry , Diot Alexandra , Jordan Lee , Thompson Alastair , Bourdon Jean-Christophe , Perol David , Bouvet Philippe , Diaz Jean-Jacques , Marcel Virginie
Published: October 2018

Background: Nucleolin (NCL) is a multifunctional protein with oncogenic properties. Anti-NCL drugs show strong cytotoxic effects, including in triple-negative breast cancer (TNBC) models, and are currently being evaluated in phase II clinical trials. However, few studies have investigated the clinical value of NCL and whether NCL stratified cancer patients. Here, we have investigated for the first time the association of NCL with clinical characteristics in breast cancers independently of the different subtypes. Methods: Using two independent series (n = 216; n = 661), we evaluated the prognostic value of NCL in non-metastatic breast cancers using univariate and/or multivariate Cox-regression analyses. Results: We reported that NCL mRNA expression levels are markers of poor survivals independently of tumour size and lymph node invasion status (n = 216). In addition, an association of NCL expression levels with poor survival was observed in TNBC (n = 40, overall survival (OS) p = 0.0287, disease-free survival (DFS) p = 0.0194). Transcriptomic analyses issued from The Cancer Genome Atlas (TCGA) database (n = 661) revealed that breast tumours expressing either low or high NCL mRNA expression levels exhibit different gene expression profiles. These data suggest that tumours expressing high NCL mRNA levels are different from those expressing low NCL mRNA levels. Conclusions: NCL is an independent marker of prognosis in breast cancers. We anticipated that anti-NCL is a promising therapeutic strategy that could rapidly be evaluated in high NCL-expressing tumours to improve breast cancer management.
Choline Kinase Alpha Inhibition by EB-3D Triggers Cellular Senescence, Reduces Tumor Growth and Metastatic Dissemination in Breast Cancer
Authors: Mariotto Elena , Viola Giampietro , Ronca Roberto , Persano Luca , Aveic Sanja , Bhujwalla Zaver M. , Mori Noriko , Accordi Benedetta , Serafin Valentina , López-Cara Luisa Carlota , Bortolozzi Roberta
Published: October 2018

Choline kinase (ChoK) is the first enzyme of the Kennedy pathway leading to the biosynthesis of phosphatidylcholine (PtdCho), the most abundant phospholipid in eukaryotic cell membranes. EB-3D is a novel choline kinase α1 (ChoKα1) inhibitor with potent antiproliferative activity against a panel of several cancer cell lines. ChoKα1 is particularly overexpressed and hyperactivated in aggressive breast cancer. By NMR analysis, we demonstrated that EB-3D is able to reduce the synthesis of phosphocholine, and using flow cytometry, immunoblotting, and q-RT-PCR as well as proliferation and invasion assays, we proved that EB-3D strongly impairs breast cancer cell proliferation, migration, and invasion. EB-3D induces senescence in breast cancer cell lines through the activation of the metabolic sensor AMPK and the subsequent dephosphorylation of mTORC1 downstream targets, such as p70S6K, S6 ribosomal protein, and 4E-BP1. Moreover, EB-3D strongly synergizes with drugs commonly used for breast cancer treatment. The antitumorigenic potential of EB-3D was evaluated in vivo in the syngeneic orthotopic E0771 mouse model of breast cancer, where it induces a significant reduction of the tumor mass at low doses. In addition, EB-3D showed an antimetastatic effect in experimental and spontaneous metastasis models. Altogether, our results indicate that EB-3D could be a promising new anticancer agent to improve aggressive breast cancer treatment protocols.
A New Tool in the Quest for Biocompatible Phthalocyanines: Palladium Catalyzed Aminocarbonylation for Amide Substituted Phthalonitriles and Illustrative Phthalocyanines Thereof
Authors: Tomé Vanessa A. , Calvete Mário J. F. , Vinagreiro Carolina S. , Aroso Rafael T. , Pereira Mariette M.
Published: October 2018

The amide peptide bond type linkage is one of the most natural conjugations available, present in many biological synthons and pharmaceutical drugs. Hence, aiming the direct conjugation of potentially biologically active compounds to phthalocyanines, herein we disclose a new strategy for direct modulation of phthalonitriles, inspired by an attractive synthetic strategy for the preparation of carboxamides based on palladium-catalyzed aminocarbonylation of aryl halides in the presence of carbon monoxide (CO) which, to our knowledge, has never been used to prepare amide-substituted phthalonitriles, the natural precursors for the synthesis of phthalocyanines. Some examples of phthalocyanines prepared thereof are also reported, along with their full spectroscopic characterization and photophysical properties initial assessment.
Low Temperature Activation of Carbon Dioxide by Ammonia in Methane Dry Reforming—A Thermodynamic Study
Authors: Kumar Anand
Published: October 2018

Methane dry reforming (MDR) is an attractive alternative to methane steam reforming for hydrogen production with low harmful environmental emissions on account of utilizing carbon dioxide in the feed. However, carbon formation in the product stream has been the most challenging aspect of MDR, as it leads to catalyst deactivation by coking, prevalent in hydrocarbon reforming reactions. Common strategies to limit coking have mainly targeted catalyst modifications, such as by doping with rare earth metals, supporting on refractory oxides, adding oxygen/steam in the feed, or operating at reaction conditions (e.g., higher temperature), where carbon formation is thermodynamically restrained. These methods do help in suppressing carbon formation; nonetheless, to a large extent, catalyst activity and product selectivity are also adversely affected. In this study, the effect of ammonia addition in MDR feed on carbon suppression is presented. Based on a thermodynamic equilibrium analysis, the most significant observation of ammonia addition is towards low temperature carbon dioxide activation to methane, along with carbon removal. Results indicate that ammonia not only helps in removing carbon formation, but also greatly enriches hydrogen production.
The Influence of Stress and Anxiety on the Expectation, Perception and Memory of Dental Pain in Schoolchildren
Authors: Lamarca Gabriela de A. , Vettore Mario V. , Monteiro da Silva Angela M.
Published: October 2018

The aim of this study was to investigate the association of stress and anxiety with the expectation, perception and memory of dental pain among schoolchildren. A follow-up study involving 46 children aged 9 to 12 years was conducted in a public school in the city of Petropolis (RJ), Brazil. Demographic characteristics, stress (children’s stress scale), and state and trait anxiety (state–trait anxiety inventory) were recorded before a dental procedure to restore the occlusal surface of a permanent first molar under local anaesthetic. Dental pain was assessed using the faces pain scale before (dental pain expectation), immediately after (dental pain perception) and six weeks after (memory of dental pain) the dental procedure. Dental pain expectation scores were significantly higher than dental pain perception, independent of the levels of stress, state anxiety and trait anxiety. Children with high scores of stress (OR 1.05 95%CI 1.02–1.09), state anxiety (OR 1.15 95%CI 1.05–1.27) and trait anxiety (OR 1.18 95%CI 1.07–1.30) were more likely to report greater scores of dental pain expectation. Children anticipated more dental pain than what was actually perceived after the dental restoration. Children with greater levels of stress and anxiety have a distorted evaluation of expected dental pain before the dental procedure.
Intercultural Pedagogy: A Faculty Learning Cohort
Authors: Lee Amy , Poch Robert , Smith Ann , Delehanty Kelly Margaret , Leopold Hannah
Published: October 2018

The purpose of this article is to describe and reflect on a pilot faculty learning cohort that was designed to improve the frequency and the quality of cross-national and cross-cultural student interactions in the participants’ undergraduate courses. The cohort offered a space where faculty could gain insight on the experience of international students (IS) and non-native English speakers (NNES), develop knowledge about best practices and relevant research, and explore and test tools to promote inclusion and interactions. The cohort focused on cross-national interactions because strong and consistent data indicate that international and domestic students seek more purposeful and substantive interactions, both in and out of the classroom, but lack the confidence and structure to engage in them.
A Universal Early Parenting Education Intervention in Community-Based Primary Care Settings: Development and Installation Challenges
Authors: Hickey Grainne , McGilloway Sinead , Leckey Yvonne , Stokes Ann
Published: October 2018

Prevention and early intervention programmes, which aim to educate and support parents and young children in the earliest stages of the family lifecycle, have become an increasingly popular policy strategy for tackling intergenerational disadvantage and developmental inequality. Evidence-based, joined-up services are recommended as best practice for achieving optimal outcomes for parents and their children; however, there are persistent challenges to the development, adoption and installation of these kinds of initiatives in community-based primary health care settings. In this paper, we present a description of the design and installation of a multi-stakeholder early parenting education and intervention service model called the Parent and Infant (PIN) programme. This new programme is delivered collaboratively on a universal, area-wide basis through routine primary care services and combines standardised parent-training with other group-based supports designed to educate parents, strengthen parenting skills and wellbeing and enhance developmental outcomes in children aged 0–2 years. The programme design was informed by local needs analysis and piloting to establish an in-depth understanding of the local context. The findings demonstrate that a hospitable environment is central to establishing interagency parenting education and supports. Partnership, relationship-building and strategic leadership are vital to building commitment and buy-in for this kind of innovation and programme implementation. A graduated approach to implementation which provides training/education and coaching as well as organisational and administrative supports for practice change, are also important in creating an environment conducive to collaboration. Further research into the impact, implementation and cost-effectiveness of the PIN programme will help to build an understanding of what works for parents and infants, as well as identifying lessons for the development and implementation of other similar complex prevention and intervention programmes elsewhere. This kind of research coupled with the establishment of effective partnerships involving service providers, parents, researchers and policy makers, is necessary to meeting the challenge of improving family education and enhancing the capacity of family services to help promote positive outcomes for children.
Reliability of Variable Speed Pumped-Storage Plant
Authors: Joseph Anto , Chelliah Thanga Raj , Lee Sze Sing , Lee Kyo-Beum
Published: October 2018

The multi-channel (MC) back-to-back voltage source inverter (VSI)-fed doubly fed induction machine (DFIM) is emerging as a highly interesting topic in large-rated variable speed pumped-storage power plants (PSPP) in view of cost, optimal efficiency, and space requirements. Although the VSI is the fundamental part of the drive controlling the active/reactive power of the plant, redundancy is presently not adopted in practice causing the unit as a whole to shut down upon a failure in the converter and control circuit. This paper evaluates a large-rated (250 MW) DFIM-fed variable-speed unit of a PSPP in terms of its reliability and availability. A Markov model is developed to assess the reliability of the drive based on a number of factors including survivability and annual failure rate (FIT). Further, the Markov model is applied to different PSPPs for comparison of reliability among them.
Hierarchical Energy Management for the MultiEnergy Carriers System with Different Interest Bodies
Authors: Huang Yu , Yang Kai , Zhang Weiting , Lee Kwang Y.
Published: October 2018

Multi-energy carriers system (MECS), in which diverse energy carriers and different energy systems interact together, has drawn the interest of many researchers in recent years. However, the optimal economic operational model of the MECS is a nonlinear, multi-variable, and multi-period problem, of which it is difficult to find the solution because several different energy flows are integrated in the system. To this end, three interest bodies in the MECS were investigated, which included the energy provider, the energy facilitator, and the energy consumer, and a hierarchical optimal economic operation strategy was then presented. A hybrid optimization strategy combining the swarm intelligence algorithm and interior point method was developed taking advantage of the merits of each method. Case studies were conducted to verify the effectiveness of the proposed hierarchical optimal economic operation strategy, whereby demonstrating that the proposed strategy can achieve rational energy allocation and decrease the energy cost in the MECS compared with traditional energy systems.
Evolution of Plant B Chromosome Enriched Sequences
Authors: Marques André , Klemme Sonja , Houben Andreas
Published: October 2018

B chromosomes are supernumerary chromosomes found in addition to the normal standard chromosomes (A chromosomes). B chromosomes are well known to accumulate several distinct types of repeated DNA elements. Although the evolution of B chromosomes has been the subject of numerous studies, the mechanisms of accumulation and evolution of repetitive sequences are not fully understood. Recently, new genomic approaches have shed light on the origin and accumulation of different classes of repetitive sequences in the process of B chromosome formation and evolution. Here we discuss the impact of repetitive sequences accumulation on the evolution of plant B chromosomes.
Prevalence of Low Back Pain and Dorsalgia and Associated Factors among Casual Dockworkers
Authors: Cezar-Vaz Marta Regina , Bonow Clarice Alves , Xavier Daiani Modernel , Vaz Joana Cezar , Cardoso Letícia Silveira , Mello Marlise Capa Verde Almeida de , Costa Valdecir Zavarese da , Sant’Anna Cynthia Fontella
Published: October 2018

This study’s aim was to analyse the relationship between musculoskeletal disorders (low back pain and dorsalgia) and sociodemographic characteristics, workload and occupational hazards among casual dockworkers. This cross-sectional study addressed casual dockworkers from the state of Rio Grande do Sul, Brazil. The convenience sample was composed of 232 casual dockworkers. Data were collected using a structured interview and observation. Poisson regression analysis was used. Association between low back pain and physiological occupational risk (p = 0.006), total exertion levels (p = 0.014) and frustration (p = 0.020) remained statistically significant, while the use of illicit drugs (p = 0.023), being a quayside worker (p = 0.021) and physiological occupational risk (p = 0.040) remained associated with dorsalgia. Decreasing these variables in the workplace may also reduce the prevalence of musculoskeletal disorders such as low back pain and dorsalgia.
Current Status and Policy Planning for Promoting Age-Friendly Cities in Taitung County: Dialogue Between Older Adults and Service Providers
Authors: Liu Li-Chuan , Kuo Hsien-Wen , Lin Chiu-Chu
Published: October 2018

The World Health Organization has promoted age-friendly city (AFC) projects in response to the aging population. Taiwan has also promoted AFC policies. This study was conducted in Taitung County, where 15.37% of the population is older adults in Taiwan. The aim was to understand the perceptions of older adults and service providers with regard to the current status of AFC policies to influence future policies. The participants of this study were older adults and service providers in various regions of Taitung. Quantitative questionnaires were completed by older adults and qualitative interviews were held with focus groups. The older adults were the most satisfied with the AFC domains of “respect and social inclusion” and “community and health services”, and the least satisfied with “transportation” and “civic participation and employment”. Homogeneity existed between the older adults’ satisfaction levels in different regions and the service providers’ opinions; however, there were notable differences between them. Both economic development and the ethnicity of groups in different regions are influential factors that determine the success of government policies. In promoting AFC policies, local governments should consider their applicability based on local conditions and resources to meet the needs of the aging population in rural areas.
Routes of Clonal Evolution into Complex Karyotypes in Myelodysplastic Syndrome Patients with 5q Deletion
Authors: Feurstein Simone , Thomay Kathrin , Hofmann Winfried , Buesche Guntram , Kreipe Hans , Thol Felicitas , Heuser Michael , Ganser Arnold , Schlegelberger Brigitte , Göhring Gudrun
Published: October 2018

Myelodysplastic syndrome (MDS) can easily transform into acute myeloid leukemia (AML), a process which is often associated with clonal evolution and development of complex karyotypes. Deletion of 5q (del(5q)) is the most frequent aberration in complex karyotypes. This prompted us to analyze clonal evolution in MDS patients with del(5q). There were 1684 patients with low and intermediate-risk MDS and del(5q) with or without one additional cytogenetic abnormality, who were investigated cytogenetically in our department, involving standard karyotyping, fluorescence in situ hybridization (FISH) and multicolor FISH. We identified 134 patients (8%) with aspects of clonal evolution. There are two main routes of cytogenetic clonal evolution: a stepwise accumulation of cytogenetic events over time and a catastrophic event, which we defined as the occurrence of two or more aberrations present at the same time, leading to a sudden development of highly complex clones. Of the 134 patients, 61% underwent a stepwise accumulation of events whereas 39% displayed a catastrophic event. Patients with isolated del(5q) showed significantly more often a stepwise accumulation of events rather than a catastrophic event. The most frequent aberrations in the group of stepwise accumulation were trisomy 8 and trisomy 21 which were significantly more frequent in this group compared to the catastrophic event group. In the group with catastrophic events, del(7q)/-7 and del(17p)/-17 were the most common aberrations. A loss of 17p, containing the tumor suppressor gene TP53, was found significantly more frequent in this group compared to the group of stepwise accumulation. This leads to the assumption that the loss of TP53 is the driving force in patients with del(5q) who undergo a sudden catastrophic event and evolve into complex karyotypes.
The Importance of the Right Framework: Mitogen-Activated Protein Kinase Pathway and the Scaffolding Protein PTPIP51
Authors: Dietel Eric , Brobeil Alexander , Gattenlöhner Stefan , Wimmer Monika
Published: October 2018

The protein tyrosine phosphatase interacting protein 51 (PTPIP51) regulates and interconnects signaling pathways, such as the mitogen-activated protein kinase (MAPK) pathway and an abundance of different others, e.g., Akt signaling, NF-κB signaling, and the communication between different cell organelles. PTPIP51 acts as a scaffold protein for signaling proteins, e.g., Raf-1, epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (Her2), as well as for other scaffold proteins, e.g., 14-3-3 proteins. These interactions are governed by the phosphorylation of serine and tyrosine residues of PTPIP51. The phosphorylation status is finely tuned by receptor tyrosine kinases (EGFR, Her2), non-receptor tyrosine kinases (c-Src) and the phosphatase protein tyrosine phosphatase 1B (PTP1B). This review addresses various diseases which display at least one alteration in these enzymes regulating PTPIP51-interactions. The objective of this review is to summarize the knowledge of the MAPK-related interactome of PTPIP51 for several tumor entities and metabolic disorders.
Fluorescent Bis(guanidine) Copper Complexes as Precursors for Hydroxylation Catalysis
Authors: Strassl Florian , Hoffmann Alexander , Grimm-Lebsanft Benjamin , Rukser Dieter , Biebl Florian , Tran Mai , Metz Fabian , Rübhausen Michael , Herres-Pawlis Sonja
Published: October 2018

Bis(guanidine) copper complexes are known for their ability to activate dioxygen. Unfortunately, until now, no bis(guanidine) copper-dioxygen adduct has been able to transfer oxygen to substrates. Using an aromatic backbone, fluorescence properties can be added to the copper(I) complex which renders them useful for later reaction monitoring. The novel bis(guanidine) ligand DMEG2tol stabilizes copper(I) and copper(II) complexes (characterized by single crystal X-ray diffraction, IR spectroscopy, and mass spectrometry) and, after oxygen activation, bis(µ-oxido) dicopper(III) complexes which have been characterized by low-temperature UV/Vis and Raman spectroscopy. These bis(guanidine) stabilized bis(µ-oxido) complexes are able to mediate tyrosinase-like hydroxylation activity as first examples of bis(guanidine) stabilized complexes. The experimental study is accompanied by density functional theory calculations which highlight the special role of the different guanidine donors.
PG-Priming Enhances Doxorubicin Influx to Trigger Necrotic and Autophagic Cell Death in Oral Squamous Cell Carcinoma
Authors: Lin Shian-Ren , Weng Ching-Feng
Published: October 2018

Synergistic effects between natural compounds and chemotherapy drugs are believed to have fewer side effects with equivalent efficacy. However, the synergistic potential of prodigiosin (PG) with doxorubicin (Dox) chemotherapy is still unknown. This study explores the synergistic mechanism of PG and Dox against oral squamous cell carcinoma (OSCC) cells. Three OSCC cell lines were treated with different PG/Dox combinatory schemes for cytotoxicity tests and were further investigated for cell death characteristics by cell cycle flow cytometry and autophagy/apoptosis marker labelling. When OSCC cells were pretreated with PG, the cytotoxicity of the subsequent Dox-treatment was 30% higher than Dox alone. The cytotoxic efficacy of PG-pretreated was found better than those of PG plus Dox co-treatment and Dox-pretreatment. Increase of Sub-G1 phase and caspase-3/LC-3 levels without poly (ADP-ribose) polymeras (PARP) elevation indicated both autophagy and necrosis occurred in OSCC cells. Dox flux after PG-priming was further evaluated by rhodamine-123 accumulation and Dox transporters analysis to elucidate the PG-priming effect. PG-priming autophagy enhanced Dox accumulation according to the increase of rhodamine-123 accumulation without the alterations of Dox transporters. Additionally, the cause of PG-triggered autophagy was determined by co-treatment with endoplasmic reticulum (ER) stress or AMP-activated protein kinase (AMPK) inhibitor. PG-induced autophagy was not related to nutrient deprivation and ER stress was proved by co-treatment with specific inhibitor. Taken together, PG-priming autophagy could sensitize OSCC cells by promoting Dox influx without regulation of Dox transporter. The PG-priming might be a promising adjuvant approach for the chemotherapy of OSCC.
Ice Forecasting in the Next-Generation Great Lakes Operational Forecast System (GLOFS)
Authors: Anderson Eric J. , Fujisaki-Manome Ayumi , Kessler James , Lang Gregory A. , Chu Philip Y. , Kelley John G.W. , Chen Yi , Wang Jia
Published: October 2018

Ice Cover in the Great Lakes has significant impacts on regional weather, economy, lake ecology, and human safety. However, forecast guidance for the lakes is largely focused on the ice-free season and associated state variables (currents, water temperatures, etc.) A coupled lake-ice model is proposed with potential to provide valuable information to stakeholders and society at large about the current and near-future state of Great Lakes Ice. The model is run for three of the five Great Lakes for prior years and the modeled ice cover is compared to observations via several skill metrics. Model hindcasts of ice conditions reveal reasonable simulation of year-to-year variability of ice extent, ice season duration, and spatial distribution, though some years appear to be prone to higher error. This modeling framework will serve as the basis for NOAA’s next-generation Great Lakes Operational Forecast System (GLOFS); a set of 3-D lake circulation forecast modeling systems which provides forecast guidance out to 120 h.
Wear Resistance Mechanism of Alumina Ceramics Containing Gd2O3
Authors: Wu Tingting , Su Jianxiu , Li Yongfeng , Zhao Hongyuan , Zhang Yaqi , Zhang Mingming , Wu Bolin
Published: October 2018

Excellent wear resistance of alumina ceramics is a desirable quality for many products. The purpose of this work was to improve the wear resistance of 99% alumina ceramics in an Al2O3–Gd2O3–SiO2–CaO–MgO (AGSCM) system. The content of Gd2O3 varied from 0.01% to 1%. A test of wear rate was performed in a ball milling apparatus in a water environment according to the Chinese industry standard. The compositions and microstructure of this material, as well as the effect of bulk density on wear rate, were studied. The effect of Gd2O3 on phases, grain growth mode, and grain boundary cohesion was investigated. It was found that Gd2O3 could refine grain size, form compressive stress of the grain boundary, and promote the crystallization of CaAl12O19. The wear rate of this material was as low as 0.00052‰ (the Chinese industry standard wear rate is ≤0.15‰). The mechanisms for wear resistance of AGSCM ceramics were also determined.
Effects of Pyrazine Derivatives and Substituted Positions on the Photoelectric Properties and Electromemory Performance of D–A–D Series Compounds
Authors: Song Xuejing , Kong Lingqian , Du Hongmei , Li Xiangyu , Feng Hanlin , Zhao Jinsheng , Xie Yu
Published: October 2018

Pyrazine derivatives quinoxaline and pyridopyrazine were selected as the acceptors, and benzocarbazole was used as the donor to synthesize four different D–A–D compounds. The results showed that 2,3-bis(decyloxy)pyridine[3,4-b]pyrazine (DPP) exhibited stronger electron-withdrawing ability than that of 2,3-bis(decyloxy)quinoxaline (DPx), because DPP possesses one more nitrogen (N) atom, resulting in a red-shift of the intramolecular charge transfer (ICT) absorption bands and fluorescent emission spectra for compounds with DPP as the acceptor compared with those that use DPx as the acceptor. The band-gap energy (Eg) of the four D–A–D compounds were 2.82 eV, 2.70 eV, 2.48 eV, and 2.62 eV, respectively, for BPC-2DPx, BPC-3DPx, BPC-2DPP, and BPC-3DPP. The solvatochromic effect was insignificant when the four compounds were in the ground state, which became significant in an excited state. With increasing solvent polarity, a 30–43 nm red shift was observed in the emissive spectra of the compounds. The thermal decomposition temperatures of the four compounds between 436 and 453 °C had very high thermal stability. Resistor-type memory devices based on BPC-2DPx and BPC-2DPP were fabricated in a simple sandwich configuration, Al/BPC-2DPx/ITO or Al/BPC-2DPP/ITO. The two devices showed a binary non-volatile flash memory, with lower threshold voltages and better repeatability.
Severe Brief Resolved Unexplained Event in a Newborn Infant in Association with Maternal Sertralin Treatment during Pregnancy
Authors: Pocivalnik Mirjam , Danda Manfred , Urlesberger Berndt , Raith Wolfgang
Published: October 2018

Background: Selective serotonin reuptake inhibitors are a very common choice of antidepressive drug-therapy during pregnancy. In up to 30% of cases, they have been found to cause neonatal abstinence syndrome in newborn infants. Although often both time-limiting and self-limiting, severe symptoms of neonatal abstinence syndrome (NAS) can occur. Methods/Results: We report a term male infant suffering from a severe brief resolved unexplained event caused by his mother’s sertraline intake during pregnancy. Conclusions: Newborn infants exposed to selective serotonine reuptake inhibitors (SSRIs) during pregnancy should be evaluated very carefully concerning NAS and monitored for NAS symptoms for a minimum of 72–96 h, or until symptoms have fully recovered using standardized protocols. There is a risk of severe NAS symptoms which might occur, and this circumstance should be discussed with the parents and taken into account before administering the drug.