bluuebunny/crossref_metadata_2025 huggingface dataset:
Visual Style of 21 Intelectual Property Right (IPR) Certified Lasem Batik Motifs as the Expression of Cultural Hybridity
Authors: Setyoningrum Yunita , Lukman Christine Claudia , Rismantojo Sandy
Published: January 2020

The problem in this research derived from the fact that many Lasem batik entrepreneurs nowadays had limited knowledge of the novel characteristics of Lasem batik and hardly aware of its geographical indication. The research objective was to identify how the cultural hybridity of Chinese-Javanese culture and Lasem geographical environment were reflected by both the Tionghoa Peranakan-descent and Javanese-descent artists through the visual signs in the batik design. The purposive samples used were 21 Lasem batik motifs made by Tionghoa Peranakan-descent and Javanese-descent entrepreneurs which already IPR-certified. The method used was a compositional interpretation by interpreting each batik motif composition according to its content (subject matter), color, spatial organization, and expressive content (the combined effect of subject matter and visual form). The finding reveals that Lasem visual style hybridity is generally visible in: (1) the use of Chinese subject matter combined with Javanese motifs, (2) the use of Chinese subject matter combined with local Javanese isen-isen (texture), and (3) the rich use of red (from Chinese batik visual style) combined with brown (from Javanese batik visual style). This finding can be used as a reference guide for latter Lasem batik entrepreneurs to maintain the particular characteristics of Lasem batik while developing other batik motifs innovation.
The Effects of Perceived Supervisor Support and Servant Leadership on Voluntary Turnover
Authors: Purba Debora Eflina , Fawzi Ahmad Raldiano
Published: January 2020

This research aimed to investigate the predictive validity of perceived supervisor support and servant leadership on voluntary turnover. Data were taken from employees and ex-employees of five batches of the development program in a company in Jakarta, Indonesia (N = 92). The data were analyzed using a logistic regression technique on Statistical Packages for Social Sciences (SPSS) software. The results show that both perceived supervisor support and servant leadership are negatively related to voluntary turnover. The servant leadership accounts for more variance on voluntary turnover and perceived supervisor support. The theoretical and practical implications of the findings are further discussed.
The Effectiveness of Reminiscence Therapy in Improving Elderly’s Well-Being
Authors: Firdaus Etty Sabariah , Widyarini Nilam , Mustika Martina Dwi
Published: January 2020

The research discussed Subjective well-being (SWB) with reminiscence therapy in the elderly. This research used a single-case experiment design to examine the effectiveness of reminiscence therapy in improving the well-being of active, elderly aged 70 years old and over. There were two participants in this research, one male and one female. This intervention consisted of five meetings held once a week for ±90 minutes each session. Quantitative analysis using the Oxford Happiness Questionnaire and qualitative analysis through observation and interviews showed an improvement in participants’ subjective well-being following the intervention. Therefore, the results of this research are likely that reminiscence therapy is effective in improving the subjective well-being of elderly individuals.
Interpersonal Metadiscourse Markers as Persuasive Strategies in Oral Business Presentation
Authors: Kuswoyo Heri , Siregar Rani Andini
Published: January 2020

This research was conducted to examine the use of interpersonal metadiscourse markers (IMDMs) in Steve Jobs’ oral business presentation using Hyland’s model. It further aimed to investigate the interpersonal metadiscourse categories and subcategories applied and most predominantly occurring in the type of oral business presentation. A descriptive qualitative method was employed in this research. One and a half-hour of Steve Jobs’ keynotes at annual Macworld tradeshow on January 9th, 2007 were collected and analyzed. The results reveal that interactional subcategory; engagement markers are mostly used by Steve Jobs. Meanwhile, in interactive subcategory transition markers are dominantly used. It indicates that by using interpersonal metadiscourse markers, Steve Jobs expresses his idea, supports his argument, and convinces the audiences by establishing a relationship with them. This research also argues that metadiscourse theory facilitates an involvement between the speaker and the listener and provides a way for mutual comprehension. Thus, the findings have a pivotal implication on how IMDMs might improve the field related to communication skills in professional life or business.
Javanese Perspective of Nonverbal Language: An Ethnopragmatic Study
Authors: Pranowo Pranowo
Published: January 2020

The research focused on nonverbal language (NvL) of Javanese people in Indonesia who spoke the first Javanese language and the second language Indonesian using an ethnopragmatic approach. The purpose of research was to describe the perception of the Javanese community on the use of NvL, both dynamic and static NvL. This research used a descriptive qualitative method with data collection techniques through observation of people who were communicating, interviews with resource persons, and recording as supporting techniques for data collection. Data were analyzed by steps; data identification, classification, and interpretation. The results of research have theoretical implications. If aspects of local wisdom such as those possessed by the Javanese people are preserved, it will be able to provide benefits to the preservation of culture that has been passed down through generations in Javanese society. Such conditions will be able to illustrate that the community’s perspective on Javanese culture is still well maintained from the past until now.
EXPERIENCE WITH SUBCUTANEOUS TRASTUZUMAB USED IN RUSSIAN FEDERATION
Authors: Lubennikova E. V. , Ganshina I. P. , Lud A. N. , Komov D. V. , Kolyadina I. V. , Vishnevskaya Y. V. , Vorotnikov I. K. , Stroyakovsky D. L. , Savelov N. A. , Semiglazov V. F. , Manikhas А. G. , Osheychik А. V. , Strelnikova T. B. , Zeynalova K. R. , Zhukova L. G.
Published: January 2020

The HannaH study showed that neoadjuvante-adjuvant subcutaneous and intravenous trastuzumab have similar efficacy and tolerability in patients with early HER2-positive breast cancer. The analysis of the results of the subcutaneous and intravenous trastuzumab usage in  Russian population showed  the favorable association between tpCR anf EFS. tpCR achiviement is associated with clinical benefit in HER2 positive breast cancer. For patients with difficult venous access who do not require intravenous chemotherapy currently, Subcutaneous trastuzumab allows  to receive effective treatment without the risk of complications, which involves catheterization of a Central vein.
MODERN VIEWS ON THE ETIOPATHOGENESIS, CLINICAL PATTERN AND TREATMENT OF DYSMENORRHEA
Authors: Unanyan A. L. , Sidorova I. S. , Chushikov Y. I. , Nikonets A. D. , Baburin D. V.
Published: January 2020

The article is devoted to the subject of topical interest to women of reproductive age. Affecting not only the health of women, but also various aspects of their life, dysmenorrhea is a medical and social problem. The use of nonsteroidal anti-inflammatory agents in this condition is an effective means of pathogenetic therapy that significantly improves the quality of life of women.
THERAPY OF UROGENITAL INFECTIONS DURING PREGNANCY
Authors: Tyutyunnik V. L. , Kan N. E. , Lomova N. A. , Medzhidova M. K.
Published: January 2020

Urogenital infections (UGI) remain one of the urgent problems of obstetrics and gynecology. In the period of gestation, the UGI may cause such complications as chorioamnionitis, intrauterine growth retardation and intrauterine and intrapartum infection of the fetus, spontaneous abortions, premature birth, purulent-septic complications in the postpartum period. According to the literature, UGI in pregnant women have a high prevalence and often occur in a latent form, complicating timely diagnosis and subsequent treatment.
TRENDS OF INITIAL METABOLIC SYNDROME AND ITS RELATIONSHIP WITH SUBCLINICAL ATHEROSCLEROSIS AMONG YOUNG AND MIDDLE-AGED MEN
Authors: Serdyukov D. Y. , Gordienko A. V. , Dyidyishko V. T. , Panova M. A. , Rudchenko I. V.
Published: January 2020

Atherosclerotic cardiovascular diseases substantially have contributing to mortality and structure of disability in developed countries. Metabolic syndrome is a cluster of clinico-biochemical changes with the most aterogenic potential.

Objective: to determine trends of early stages of metabolic syndrome and its relationship with the initial atherosclerosis in young and middle-aged men. Have been examined 436 men with an assessment symptoms of metabolic syndrome, as well as signs of subclinical atherosclerosis. The young men with initial manifestations of metabolic syndrome were characterized by the classical cardiovascular risk factors. According to the results of the study have been already diagnosed dyslipidemia, violation of apolipoproteides fractions, postprandial hyperglycemia at the initial stage of metabolic syndrome in this category of patients. have been proposed assessment of waist circumference, degree of diastolic blood pressure and postprandial glycemia as the most sensitive diagnostic markers of cardiovascular lesions in primary manifestations of metabolic syndrome.
A NEW INDICATION FOR EMPAGLIFLOZIN: TURNING POINT IN THE TREATMENT OF TYPE 2 DIABETES
Authors: Amosova M. V. , Fadeev V. V.
Published: January 2020

In today’s clinical practice, the treatment of type 2 diabetes mellitus should be targeted not only at achieving glycemic control, but should also affect other modified risk factors for cardiovascular disease including hypertension, overweight, frequent hypoglycemia, etc. [4] Empagliflozin is the first antidiabetic drug with the new approved indication allowing it to be used for the reduction of cardiovascular mortality risks in patients with type 2 diabetes and comorbid cardiovascular diseases.
THE ROLE OF DYSLIPIDEMIA IN THE PROGRESSION OF DIABETIC RETINOPATHY
Authors: Kuzmin A. G. , Martynov S. A. , Shestakova M. V.
Published: January 2020

Angiogenesis factors, growth factors (vascular endothelial growth factor (VEGF), angiopoietin-2, insulin-like growth factor, etc.) and cytokines play the leading role in the production by endothelial cells of new retinal blood vessels, increased vascular permeability resulting in exudation and macular edema leading to the development of irreversible complications and vision loss. Although large-scale clinical trials demonstrated that tight control of glycemia and normalization of systemic blood pressure reduce the risk of progression of diabetic retinopathy (DR), the relationship between lipid disorders and retinal damage is not fully understood.
THE ROLE OF GLYCATED HEMOGLOBIN IN THE DIAGNOSIS AND IMPROVED PROGNOSIS OF DIABETES MELLITUS
Authors: Biryukova E. V.
Published: January 2020

The focus on the problem of diabetes mellitus (DM) is associated with the increasing prevalence of the disease and the risk for the development of many vascular complications (nephropathy, retinopathy, lesions of the great vessels of the heart, brain, peripheral vascular disease of the lower limbs), in the development of which chronic hyperglycemia plays a crucial role. In 2011, the WHO decided that glycated hemoglobin (HbA1c) could be used as the diagnostic criterion for diabetes. The role of HbA1c in the choice of hypoglycemic therapy is invaluable. According to the Algorithms of Specialized Medical Care for Diabetes Mellitus Patients, stratification of treatment strategy in patients with newly diagnosed type 2 diabetes is determined by the initial HbA1c.
PROSPECTS OF NEPHROPROTECTION AGAINST TYPE 2 DIABETES USING THE DPP-4 INHIBITOR VILDAGLIPTIN
Authors: Bayrasheva V. K. , Babenko A. Y. , Bayramov A. A. , Chefu S. G. , Shatalov I. S. , Pchelin I. Y. , Arefieva A. N. , Grineva E. N.
Published: January 2020

Diabetic nephropathy (DN) is a serious complication of diabetes mellitus (DM), which increases morbidity and mortality. Accumulated evidence, mostly experimental ones that DPP-4 inhibitors have non-glycemic tissue effects including renal protection. Clinical data confirming these effects are insufficient. This makes it relevant to study the influence of iDPP-4 on the renal function in patients with Type 2 diabetes.

To study the effects of iDPP vildagliptin on glycemic, metabolic and renal parameters in patients with type 2 diabetes with CKD 1–2 receiving insulin therapy 44 patients were randomized to continue therapy with insulin or insulin + vildagliptin at a dose of 50 mg/day, with the evaluation of results in 6 months.

In group of vildagliptin therapy a significant decrease of HbA1c, postprandial glycemia, diastolic blood pressure, HOMA-IR, insulin demand and a reduction in the frequency of hypoglycemia occurred. The positive dynamics of indicators of glomerular functions of the kidney were noted in this group - a significant reduction in albuminuria and a significant increase in eGFR by cystatin C and decreased urinary excretion of type IV collagen. The findings suggest the positive effect of vildagliptin on metabolic status and indicators of glycaemia and hemodynamics as earlier confirmed in clinical studies and the ability of vildagliptin independent from glycemic effects to slow the development of glomerular dysfunction in patients with type 2 diabetes and the initial manifestations of DN.
CLINICAL FOLLOW-UP OF A PATIENT WITH OBESITY AND SUBCLINICAL HYPOTHYROIDISM DURING TREATMENT WITH SIBUTRAMINE AND LEVOTHYROXINE SODIUM
Authors: Troshina E. A. , Galieva M. O. , Mikhina M. S. , Mazurina N. V.
Published: January 2020

Among comorbidities of obesity, hypothyroidism is the most common endocrinopathy. The pathogenesis of both diseases is based on serotonin deficiency. The article tells about a clinical case of a patient with obesity and subclinical hypothyroidism; a comprehensive examination allowed to choose the efficient and safe pathogenetic therapy.
Treatment of Bisphenol A (BPA) in water using UV/H2O2 and reverse osmosis (RO) membranes: assessment of estrogenic activity and membrane adsorption
Authors: Moreira Carolina G. , Moreira Mariana H. , Silva Vanessa M. O. C. , Santos Henrique G. , Bila Daniele M. , Fonseca Fabiana V.
Published: January 2020

Removal of an endocrine disrupting compound, Bisphenol A (BPA), from water was investigated using two treatment processes, UV/H2O2 advanced oxidation (AOP) and reverse osmosis (membrane separation). Furthermore, changes in estrogenic activity using in vitro yeast estrogen screen assay as well as the adsorption of BPA by the membrane surface were evaluated. The best UV/H2O2 performance was obtained using the highest established values of all parameters, reaching 48% BPA removal. Within the investigated conditions of the AOP, when lower doses of UV were used, a higher removal efficiency was achieved at a higher initial concentration of BPA. However, the same behavior was not observed for the highest UV dose, in which the removal efficiency was not dependent on BPA initial concentration. In both cases, removal efficiency increased as H2O2 concentration increased. The formation of estrogenic by-products was observed in UV/H2O2. The membrane rejection efficiency varied from 60% to 84% and all experiments showed adsorption of BPA by the membrane surface. The RO membrane showed a greater BPA removal efficiency for samples containing 10 μg·L−1 than UV/H2O2 at the evaluated treatment conditions.
Percepção da corrupção em ambiente acadêmico: análise empírica a partir de alunos do curso de ciências contábeis da Universidade Federal do Ceará (UFC)
Authors: Do Nascimento Roberto Sérgio , Pinho Ruth Carvalho de Santana
Published: January 2020

Objetivo: A corrupção é um fenômeno mundial que atinge, indistintamente, pobres e ricos. Como fenômeno multidisciplinar, compreender o problema tornou-se um aspecto complexo dado à diversidade de conceitos que abarca e a forma como se apresenta nos países. Neste sentido, o presente trabalho objetiva analisar aspectos significativos do perfil social que influenciam a percepção da corrupção por parte dos alunos de Ciências Contábeis da Universidade Federal do Ceará.

Metodologia: A pesquisa se caracteriza como descritiva quanto aos objetivos, de levantamento quanto aos procedimentos e quantitativa quanto à natureza. Utilizou-se questionário com escala do tipo Likert, preenchido de forma anônima, formado por 4 grupos de perguntas, nos quais se alocou 20 questões associadas ao tema corrupção (compreensão, impacto profissional, estrutura atual do curso de ciências contábeis e mecanismos institucionais para o seu combate). A análise dos resultados se deu por intermédio da estatística descritiva.

Resultados: Foram considerados posicionamentos intermediários que não revelam a total negação ou confirmação das perguntas apresentadas, o que evidencia que parte das opiniões ainda se encontra em construção. A exceção se deve ao nível de compreensão do fenômeno que foi considerado satisfatório pelos pesquisadores. No que se refere às respostas intermediárias, os resultados apontam para a necessidade de múltiplas soluções em relação ao fenômeno estudado: aprimoramento do tratamento do tema por parte do curso como um todo, melhora da compreensão da amplitude da corrupção como fenômeno que atinge também empresas e organizações sociais e afastamento do entendimento dos alunos de que o curso deve prover conhecimento acerca do modus operandi dos atos corruptos.  

Contribuições do Estudo: O estudo contribui para que novas formas de abordagem da corrupção sejam desenvolvidas para o ambiente acadêmico, notadamente do Curso de Ciências Contábeis, visando aumentar a percepção sobre o tema.
As informações contábeis dos balanços versus os indicadores de satisfação de usuários: os casos do Metrô e da CPTM em São Paulo
Authors: Holanda Bruna de Morais , Alexandrino Lucas Custódio , Crozatti Jaime
Published: January 2020

Objetivo: Verificar se existe relação entre os dados contábeis e a satisfação dos usuários relativos à política de transporte sobre trilhos na Região Metropolitana de São Paulo (RMSP) pela análise de informações de demonstrativos contábeis e da satisfação dos usuários das empresas públicas Companhia do Metropolitano de São Paulo (Metrô) e Companhia Paulista de Trens Metropolitano (CPTM), de 2010 a 2017.
Metodologia: Os dados das Demonstrações Contábeis e da Satisfação dos Usuários obtidos dos sites das empresas e da Associação Nacional de Transportes Públicos (ANTP) são comparados no time line do Metrô e da CPTM de forma descritiva em Tabelas e Figuras e de forma explicativa com a correlação de Pearson e a Regressão Multivariada.
Resultados: As análises corroboram as críticas de que a falta de investimentos e dos valores do Ativo e do Resultado Econômico Anual (Prejuízo) no sistema de transportes sobre trilhos na Região Metropolitana de São Paulo estão na base da crise de mobilidade urbana que afeta diretamente as classes menos favorecidas de forma que as classes sociais mais baixas da população que reside nas periferias da RMSP recebem considerável menor montante de investimentos e piores níveis de satisfação pelo serviço prestado.
Contribuições do Estudo: Qualifica, com dados oficiais e de pesquisa de satisfação, a gestão e a qualidade do serviço ofertado pelo Metrô e pela CPTM como principais gestoras do serviço de transporte público da RMSP, a maior concentração de pessoas do hemisfério sul do globo.
O aumento do imposto sobre a propriedade de veículo automotores em tempo de recessão econômica e o reflexo na sua arrecadação
Authors: Lima Lauro Vinício de Almeida , Diniz Josedilton Alves , Machado Márcia Reis
Published: January 2020

Objetivo: A pesquisa teve como objetivo analisar o comportamento da arrecadação do Imposto sobre a Propriedade de Veículos Automotores (IPVA) em relação ao aumento de suas alíquotas ocorrido no ano de 2016, durante a recessão econômica brasileira iniciada no final de 2014.
Metodologia: Em uma análise quantitativa dos dados em painel dos 26 Estados e o Distrito Federal do Brasil, entre os anos de 2004 a 2016, a pesquisa teve por base a teoria das escolhas públicas, a capacidade fiscal e a elasticidade da receita tributária, propondo um modelo regressivo para estimar o reflexo do aumento da alíquota do IPVA, durante a recessão econômica, na arrecadação tributária, utilizando como variáveis a arrecadação do IPVA por veículos licenciados, o PIB per capita, o tamanho da população e a taxa de desemprego.
Resultados: Os resultados obtidos apontam para uma saturação a capacidade econômica dos contribuintes daquele imposto, corroborando a hipótese de que a recessão econômica pode ter afetado a capacidade contributiva, de tal modo, que o aumento da alíquota do IPVA durante a recessão econômica pode ter favorecido a sua inadimplência do imposto.
Contribuições do Estudo: O estudo pode contribuir para ampliar a compreensão das consequências relacionadas às oscilações na carga tributária e o processo de tomada de decisão no setor público quanto à adoção de uma política fiscal que prime pela eficiência e equilíbrio, entre carga tributária e capacidade econômica dos contribuintes, com vistas à neutralização de tendências à depressão econômica e a inflação, nos ciclos econômicos, ainda que seja necessário reduzir a carga tributária, para que a arrecadação se mantenha no nível para manutenção do equilíbrio orçamentário e atenção aos gastos públicos previstos.
Provável, possível ou remoto? Um estudo acerca das contingências tributárias dos bancos brasileiros
Authors: Schmitt Matheus , Fagundes Ernando , Alex Mussoi Ribeiro
Published: January 2020

Objetivo: Identificar fatores determinantes na classificação das provisões e passivos contingentes tributários pelas instituições financeiras brasileiras. A natureza tributária foi escolhida devido a representatividade destas contingências. Já as instituições financeiras foram elencadas pela escassez de pesquisas similares.

Metodologia: Para analisar os fatores determinantes da classificação provisões e contingências foi utilizado um modelo de regressão logística. As empresas analisadas pertencem a Brasil, Bolsa, Balcão (B3) e o período analisado compreende o exercício de 2016.

Resultados: A média dos processos em que as instituições financeiras são rés apresentam 5 anos de instauração e o valor relativo dos processos (razão entre montante do processo e ativo da empresa) representa em média 0,4%. Os resultados do estudo corroboram a Ribeiro (2012), uma vez que existe divergência de opiniões na interpretação da legislação e na determinação da chance de perda, sendo uma prática factível de gerenciamento de resultados. Corrobora com Hennes (2014), visto que observou a insuficiência das divulgações quantitativas para determinar as expectativas de perda e com Aharony e Dotan (2004) que demonstraram o menor conservadorismo dos gestores e auditores quando comparados aos analistas financeiros. Alinhando aos estudos similares e a Teoria Positiva da Contabilidade, conclui-se que a discricionariedade fornecida aos gestores pode contribuir no gerenciamento de informações, possibilitando o uso desta com intuito informativo ou oportunista.

Contribuições do Estudo: A contribuição deste estudo está em elucidar questões relacionadas aos elementos que direcionam os critérios de classificação das provisões e dos passivos contingentes utilizados pelos gestores. Assim, contribui evidenciando como características relacionadas com os processos (esfera administrativa ou judicial), a instância, o seu valor e seu prazo de condução podem influenciar na classificação como provável, possível ou remoto.
Método do caso: um relato sobre sua efetividade e aplicabilidade no ensino de contabilidade
Authors: Januário Alessandro Henrique de Araújo , Pinho Cássia Marcelle Dias , Gonçalves Tadeu Junior de Castro , Araújo Aneide Oliveira
Published: January 2020

Objetivo: Investigar a efetividade e a aplicabilidade do método do caso junto a alunos do mestrado em ciências contábeis da Universidade Federal do Rio Grande do Norte (UFRN).

Metodologia: O estudo realizado foi caracterizado como descritivo e a coleta de dados se deu através de um questionário com perguntas abertas após a aplicação de um caso. O tratamento dos dados foi realizado através de análise de conteúdo com auxílio do software ATLAS.ti®.

Resultados: No que diz respeito à efetividade, destacou-se a interação dos alunos a partir das discussões em pequenos grupos para, posteriormente, no grande grupo, ocorrer a contribuição para a resolução do caso com uma discussão mais profunda. Referente à aplicabilidade, os resultados demonstram a necessidade de utilização de outras metodologias ativas na resolução do caso, como exemplo mais citado pelos alunos, têm-se o role-play. Também foram evidenciadas as dificuldades e limitações identificadas durante a intervenção educativa, entre elas, o pouco tempo disponibilizado para a aplicação deste método e a dificuldade de se encontrar bons casos para aplicar em sala de aula.

Contribuições do estudo: O estudo contribui com as discussões acerca da adoção de metodologias ativas, o que permite a identificação de pontos fortes e fracos, assim como as limitações, oportunizando, por consequência, sugestões de melhoria e aprimoramento do processo de ensino-aprendizagem.
CRESCIMENTO POPULACIONAL, PAISAGEM E QUALIDADE DE VIDA EM POÇOS DE CALDAS (MG), UMA CIDADE MÉDIA TURÍSTICA
Authors: Carvalho de Andrade Alexandre , Moraes Ramos Giovanna , Miranda Martins Raphael
Published: January 2020

Poços de Caldas é um município localizado no Sul de Minas e tem população de 152.435 habitantes (IBGE, 2010). Desde o começo de sua formação como cidade, apresenta significativa importância da atividade turística, em especial devido as fontes de águas hidrotermais e sua paisagem montanhosa. Entretanto, em meados do século XX se iniciou um processo de diversificação e desenvolvimento da economia, o que favoreceu o crescimento populacional, a expansão urbana, e, por consequência, aconteceram diferentes impactos na qualidade de vida, na organização espacial e na paisagem local. Neste contexto, o presente trabalho tem como objetivo analisar a qualidade de vida em Poços de Caldas, por meio de indicadores quantitativos e da percepção de seus moradores.

Palavras-chave: Qualidade de Vida Urbana; Paisagens; Turismo.
Özerklik Teorisi ve Sosyal İlişki Gereksinimi Ölçeğinin Türkçeye Adaptasyonu
Authors: Ünal-karagüven Meşküre Hülya , Karaman-ekşioğlu Mukadder , Gül Çiğdem
Published: January 2020

Sosyal yönden bağlantı kurma, diğer insanların sevgi ve saygısını kazanma ihtiyacı temel bir gereksinim olarak kabul edilmektedir. Bu konu Özerklik Teorisinde incelenmiş ve ilişkililik (relatedness) ya da sosyal ilişki kurma gereksinimi olarak tanımlanmıştır. Aynı teori kapsamında sosyal ilişki kurma gereksinimi düzeyini belirleme yönelik “The Need for Relatedness Scale” (NRS-10) adıyla bir ölçek geliştirilmiştir. Ölçek Kanada’da İngilizce olarak geliştirilmiştir. Amacı, okul ve benzeri iş ortamlarında yetişkinlerin sosyal ilişki kurma gereksinimi düzeyini belirlemektir. Konuyla ilgili Türkçe çalışmalar yapabilmek için kullanımı kolay, geçerlik ve güvenirliği tatminkâr ölçme araçlarına ihtiyaç duyulmaktadır. Bu çalışmanın amacı önce Özerklik Teorisini sunmak daha sonra bu teori temelinde geliştirilen NRS-10 ölçeğinin Türkçeye adaptasyonunu sağlamaktır. NRS-10 on maddeden oluşan iki boyutlu bir ölçektir. Türkçe eşdeğerlik ön çalışması, İngilizce öğretmenliği son sınıf öğrencilerden oluşan 90 kişilik bir grupla yapılmış ve Türkçe form "Sosyal İlişki Gereksinimi Ölçeği" (SİGÖ-10) olarak adlandırılmıştır. Çalışma grubu toplamda 390 üniversite son sınıf öğrencilerinden oluşmuştur. SİGÖ-10 ile birlikte bir anket formu ve Çevresel Destek Ölçeği kullanılmıştır. Hipotez testi, yapısal faktör analizi, iç tutarlılık katsayısı ve korelasyon teknikleri kullanılmıştır. Bulgular NSR-10'un Türkçe formunun yetişkinler arasında sosyal ilişki ihtiyacı düzeyini belirlemek amacıyla kullanılabilecek bir ölçek olduğunu göstermiştir. Ölçek Türkçe çalışmalarda veri toplamak amacıyla kullanılabilir. Konu ile ilgili benzer çalışmaların yapılması önerilmiştir.
Inhibition of Cyclooxygenase Enzyme by Bioflavonoids in Horsegram Seeds Alleviates Pain and Inflammation
Authors: Ramalingam Malarvizhi , Sali Veeresh K. , Bhardwaj Meenakshi , Mani Sugumar , Vasanthi Hannah R.
Published: January 2020

Background:

Inflammation and pain, mainly induced by the prostaglandins synthesized
by the cyclooxygenase enzymes, may cause distress. To overcome this unpleasant stress in a safer
manner, numerous natural molecules are proven for modulating the COX enzymes. Epicatechin
and daidzein are two bioactive natural compounds present in horsegram, a legume known for its
medicinal properties.

Objective:

The present study aims at evaluating the potential of horsegram, and some of its
bioactive molecules, to be used as an anti-inflammatory and analgesic agent mediated by the
inhibition of COX enzymes, which can be recommended as a substitute for chemically synthesized
NSAIDs.

Methods:

The present work involved the quantification of epicatechin and daidzein present in
horsegram seeds. The COX enzyme inhibitory nature of epicatechin and daidzein was tested using
in silico docking analysis with Autodock software and was further confirmed by in vitro COX
inhibitory biochemical assays. Furthermore, the anti-inflammatory and analgesic activities of the
horsegram seeds were evaluated in animal experiments.

Results:

Horsegram seeds contain 158.1 microgram/g and 6.51 microgram/g of epicatechin and
daidzein respectively. The docking studies reveal that both the bioactive molecules exhibit better
binding efficiency with COX-2 protein as compared to COX-1. Hence, in vitro COX-2 inhibitory
assay was performed for epicatechin, daidzein and compared with known analgesic agent
diclofenac which revealed a pronounced dose dependent inhibitory activity. Furthermore, the
analgesic and anti-inflammatory activity of horsegram in experimental animals exhibited a dose
dependent effect which might be due to the presence of the bioactive compounds such as
epicatechin and daidzein.

Conclusion:

The results suggest that epicatechin and daidzein present in horsegram are potent
cyclooxygenase inhibitors and thus would be helpful in the management of inflammation and pain.
Combinatorial Synthesis of A Series of Paeonol-based Phenylsulfonyl hydrazone Derivatives as Insecticidal Agents
Authors: Che Zhi-Ping , Yang Jin-Ming , Sun Di , Tian Yue-E , Liu Sheng-Ming , Lin Xiao-Min , Jiang Jia , Chen Gen-Qiang
Published: January 2020

Background:

Plant secondary metabolites play an essential role in the discovery of
novel insecticide due to their unique sources and potential target sites. Paeonol, the main phenolic
components in Moutan Cortex, is recognized as a safe and potent botanical insecticide to many
insects. The structural modification of paeonol in this study into phenylsulfonylhydrazone
derivatives is proved an effective approach for the development of novel insecticides, those
derivatives being more toxic than paeonol. However, there have been no reports on the insecticidal
activity of paeonol-based phenylsulfonylhydrazone derivatives in controlling Mythimna separata.

Methods:

We have been working to discover biorational natural products-based insecticides.
Twelve novel paeonol-based phenylsulfonylhydrazone derivatives have been successfully prepared
by structural modification of paeonol, and the insecticidal activity against M. separata by the leafdipping
method at the concentration of 1 mg/mL has been evaluated.

Results:

Insecticidal activity revealed that out of 12 title compounds, derivatives 5c and 5f
displayed the best against M. separate with the FMR both of 53.6% than toosendanin (FMR =
50.0%).

Conclusion:

The results suggested that for the paeonol-based phenylsulfonylhydrazone series
derivatives, the proper substituent of arylsulfonyl R at the hydroxyl position of paeonol was very
important for their insecticidal activity. These preliminary results will pave the way for further
modification of paeonol in the development of potential new insecticides.
A Recent Look into Natural Products that have Potential to Inhibit Cholinesterases and Monoamine Oxidase B: Update for 2010-2019
Authors: Gulcan Hayrettin O. , Orhan Ilkay E.
Published: January 2020

With respect to the unknowns of pathophysiology of Alzheimer’s Disease (AD)-, and
Parkinson’s Disease (PD)-like neurodegenerative disorders, natural product research is still one of
the valid tools in order to provide alternative and/or better treatment options. At one hand, various
extracts of herbals provide a combination of actions targeting multiple receptors, on the other hand,
the discovery of active natural products (i.e., secondary metabolites) generally offers alternative
chemical structures either ready to be employed in clinical studies or available to be utilized as
important scaffolds for the design of novel agents. Regarding the importance of certain enzymes
(e.g. cholinesterase and monoamine oxidase B), for the treatment of AD and PD, we have surveyed
the natural product research within this area in the last decade. Particularly novel natural agents
discovered within this period, concomitant to novel biological activities displayed for known
natural products, are harmonized within the present study.
Quinoline Containing Side-chain Antimalarial Analogs: Recent Advances and Therapeutic Application
Authors: Joshi Mukesh C. , Egan Timothy J.
Published: January 2020

The side-chains of quinoline antimalarial agents are the major concern of focus to build
novel and efficaciaous bioactive and clinical antimalarials. Bioative antimalarial analogs may play a
critical role in pH trapping in the food vacuole of RBC’s with the help of fragmented amino acid, thus
lead to β-hematin inhibition. Here, the authors tried to summarize a useful, comprehensive compilation
of side-chain modified ACQs along with their synthesis, biophysical and therapeutic applications etc.
of potent antiplasmodial agents and therefore, opening the door towards the potential clinical status.
Formulation, Standardization, and a Preliminary Before-After Clinical Trial on Effect of a Traditional Herbal Formula (Maqliasa) on Manifestations of Ulcerative Colitis
Authors: Shirzad Meysam , Ahmadian-Attari Mohammad Mahdi , Ghafoori Seyed Mohammad Sadegh , Kashani Leila Mohammad Taghizadeh , Pasalar Mehdi , Abbassian Alireza , Agah Shahram
Published: January 2020

Background:

Ulcerative Colitis (UC) is a chronic condition that represents a group of
intestinal disorders causing prolonged inflammation of the digestive tract. Nowadays, efforts to
investigate new remedies have led to a committed movement toward the integration of traditional
and complementary medicine into mainstream medicine. In Traditional Persian Medicine (TPM),
Maqliasa is one of the most frequent gastrointestinal prescriptions which is claimed to be effective
in both remission and recurrent phases of UC.

Objective:

The aim of this pilot study was to examine the effect of Maqliasa on UC symptoms.

Methods:

Through a non-randomized before-after uncontrolled clinical trial, 13 outpatients with
active UC were enrolled in the study. They continued their conventional drug regimens plus
Maqliasa capsules (2 capsules t.i.d.) for 28 days. Three visits were arranged for each patient− the
first admission, day 14th admission and day 28th admission. The patients were evaluated by
Lichtiger Colitis Activity Index. Wilcoxon signed-rank test was used for statistical analysis.

Results:

The Lichtiger colitis activity index improved in the study group was compared to the corresponding
baseline values: baseline score: 7.8 ± 0.5; after two weeks: 5.9 ± 0.6 (P=0.002); after
four weeks: 3.6 ± 0.5 (P=0.001).

Conclusion:

This study showed the promising effect of Maqliasa in the treatment of active UC.
However, due to some of the limitations of the study, conducting future high-quality randomized
clinical trials would be crucial.
Importance of Stem Cell Migration and Angiogenesis Study for Regenerative Cell-based Therapy: A Review
Authors: Aziz Nur S. , Yusop Norhayati , Ahmad Azlina
Published: January 2020

Stem cells play an essential role in maintaining homeostasis, as well as participating in new tissue regeneration. Over the past 20 years, a great deal of effort has been made to investigate the behaviour of stem cells to enable their potential use in regenerative medicine. However, a variety of biological characteristics are known to exist among the different types of stem cells due to variations in the methodological approach, formulation of cell culture medium, isolation protocol and cellular niches, as well as species variation. In recent years, cell-based therapy has emerged as one of the advanced techniques applied in both medical and clinical settings. Cell therapies aim to treat and repair the injury sites and replace the loss of tissues by stimulating the repair and regeneration process. In order to enable the use of stem cells in regenerative therapies, further characterisation of cell behaviour, in terms of their proliferation and differentiation capacity, mainly during the quiescent and inductive state is regarded as highly necessary. The central focus of regenerative medicine revolves around the use of human cells, including adult stem cells and induced pluripotent stem cells for cell-based therapy. The purpose of this review was to examine the existing body of literature on stem cell research conducted on cellular angiogenesis and migration, to investigate the validity of different strategies and variations of the cell type used. The information gathered within this review may then be shared with fellow researchers to assist in future research work, engaging in stem cell homing for cell-based therapy to enhance wound healing and tissue regeneration process.
Utilization of LTEx Feynman Gate in Designing the QCA Based Reversible Binary to Gray and Gray to Binary Code Converters
Authors: Mukherjee Chiradeep , Panda Saradindu , Mukhopadhyay Asish K. , Maji Bansibadan
Published: January 2020

Aims:

The Quantum-dot Cellular Automata explores a unique perspective in the arena of
the architectural design of future quantum computers, precisely due to its ultra-low packing density,
high operating speed, and low power dissipation. On the other side, reversible computing allows the
implementation of extreme low power-consuming circuits by avoiding energy dissipation during the
time of computation.

Objective:

In this paper, we have explored the QCA design of reversible binary to gray and gray to binary
code converters based on the application of a unique model of Feynman gate using the layered T
exclusive-OR module (abbreviated in this work as LTEx Feynman gate).

Methods:

We have proposed algorithms to produce multi-control reversible binary to gray and gray to
binary code converters and to develop cost-efficient QCA layouts.

Results:

Our systematic literature survey on the existing QCA designs of reversible binary to gray and
gray to binary code converters helped us to compare and analyze the proposed design with the existing
ones and identify it as the best design in terms of reversible, and QCA design metrics.

Conclusion:

Significant improvements in design metrics owing to successful experimentations over
the previous designs are reported while instantiating 3X3,4X4, and 8X8 counterpart layouts.
Natural Rubber Latex and Its Effects on Some Properties of Bitumen.
Authors: Osei T.  , Tagbor T.  A.  , Awudza J. A.M.
Published: January 2020

:

In Ghana, the main binder for asphalt roads is bitumen. However there are many cases of early road deterioration resulting sometimes from effects of temperature on asphalt binder (bitumen). For this reason several studies are on-going to develop bitumen suitable for the climatic condition in the country. This study examines some physical properties such as softening point temperature, viscosity, penetration temperature and specific gravity and chemical functionalities, peak intensity and new functional group of AC 10 grade bitumen modified with natural rubber latex (L) at levels between 1-5% and 10% as well as its effect on aging at 5 and 10% blends. Standard methods of determinations of the physical properties, Fourier Transform Infra-Red Spectroscopy (FT-IR) Test and Short term aging test were employed. Results indicated that upon addition of 1% natural rubber latex, all the properties tested decrease. Further increasing the percentage of natural rubber latex decreases penetration point but the softening point temperature, specific gravity and viscosity increases. Spectroscopy analysis result revealed that there was no change in peaks intensities of the blends as compared to the conventional bitumen. Aging test results indicated a change in mass of 0.112% for 5% blend and 0.152% for 10% blend. The study has shown that natural rubber could improve some properties of bitumen andcould be used for constructing more durable roads.
Quality of Life of Women After a First Diagnosis of Breast Cancer Using a Self-Management Support mHealth App in Taiwan: Randomized Controlled Trial
Authors: Hou I-Ching , Lin Hsin-Yi , Shen Shan-Hsiang , Chang King-Jen , Tai Hao-Chih , Tsai Ay-Jen , Dykes Patricia C
Published: January 2020

Background

There are over 2 million newly diagnosed patients with breast cancer worldwide with more than 10,000 cases in Taiwan each year. During 2017-2018, the National Yang-Ming University, the Taiwan University of Science and Technology, and the Taiwan Breast Cancer Prevention Foundation collaborated to develop a breast cancer self-management support (BCSMS) mHealth app for Taiwanese women with breast cancer.

Objective

The aim of this study was to investigate the quality of life (QoL) of women with breast cancer in Taiwan after using the BCSMS app.

Methods

After receiving a first diagnosis of breast cancer, women with stage 0 to III breast cancer, who were recruited from social networking sites or referred by their oncologists or oncology case managers, were randomized 1:1 into intervention and control groups. Intervention group subjects used the BCSMS app and the control group subjects received usual care. Two questionnaires—the European Organization for Research and Treatment of Cancer (EORTC) Quality-of-Life Questionnaire Core 30 (QLQ-C30) and the EORTC Breast Cancer-Specific Quality-of-Life Questionnaire (QLQ-BR23)—were distributed to subjects in both arms. Paper-based questionnaires were used at baseline; paper-based or Web-based questionnaires were used at 1.5-month and 3-month follow-up evaluations. All evaluations were self-assessed and anonymous, and participants were blinded to their allocation groups. Descriptive analysis, the Pearson chi-square test, analysis of variance, and the generalized estimating equation were used to analyze the data. Missing values, with and without multi-imputation techniques, were used for sensitivity analysis.

Results

A total of 112 women were enrolled and randomly allocated to either the experimental group (n=53) or control group (n=59). The follow-up completion rate was 89.3% (100/112). The demographic data showed homogeneity between the two groups in age (range 50-64 years), breast cancer stage (stage II), marital status (married), working status (employed), and treatment status (receiving treatments). The mean total QoL summary scores from the QLQ-C30 (83.45 vs 82.23, P=.03) and the QLQ-BR23 (65.53 vs 63.13, P=.04) were significantly higher among the experimental group versus the control group, respectively, at 3 months.

Conclusions

This research provides support for using a mobile health care app to promote the QoL among women in Taiwan after a first diagnosis of breast cancer. The BCSMS app could be used to support disease self-management, and further evaluation of whether QoL is sustained is warranted.

Trial Registration

ClinicalTrials.gov NCT004174248; https://clinicaltrials.gov/ct2/show/NCT04174248
Online Impact and Presence of a Specialized Social Media Team for the Journal of Neurosurgery: Descriptive Analysis (Preprint)
Authors: Linzey Joseph R , Robertson Faith , Haider Ali S , Graffeo Christopher Salvatore , Wang Justin Z , Shasby Gillian , Alotaibi Naif M , Cohen-Gadol Aaron A , Rutka James T
Published: January 2020

BACKGROUND

Social media use continues to gain momentum in academic neurosurgery. To increase journal impact and broaden engagement, many scholarly publications have turned to social media to disseminate research. The Journal of Neurosurgery Publishing Group (JNSPG) established a dedicated, specialized social media team (SMT) in November 2016 to provide targeted improvement in digital outreach.

OBJECTIVE

The goal of this study was to examine the impact of the JNSPG SMT as measured by increased engagement.

METHODS

We analyzed various metrics, including impressions, engagements, retweets, likes, profile clicks, and URL clicks, from consecutive social media posts from the JNSPG’s Twitter and Facebook platforms between February 1, 2015 and February 28, 2019. Standard descriptive statistics were utilized.

RESULTS

Between February 2015 and October 2016, when a specialized SMT was created, 170 tweets (8.1 tweets/month) were posted compared to 3220 tweets (115.0 tweets/month) between November 2016 and February 2019. All metrics significantly increased, including the impressions per tweet (mean 1646.3, SD 934.9 vs mean 4605.6, SD 65,546.5; P=.01), engagements per tweet (mean 35.2, SD 40.6 vs mean 198.2, SD 1037.2; P<.001), retweets (mean 2.5, SD 2.8 vs mean 10.5, SD 15.3; P<.001), likes (mean 2.5, SD 4.0 vs mean 18.0, SD 37.9; P<.001), profile clicks (mean 1.5, SD 2.0 vs mean 5.2, SD 43.3; P<.001), and URL clicks (mean 13.1, SD 14.9 vs mean 38.3, SD 67.9; P<.001). Tweets that were posted on the weekend compared to weekdays had significantly more retweets (mean 9.2, SD 9.8 vs mean 13.4, SD 25.6; P<.001), likes (mean 15.3, SD 17.9 vs mean 23.7, SD 70.4; P=.001), and URL clicks (mean 33.4, SD 40.5 vs mean 49.5, SD 117.3; P<.001). Between November 2015 and October 2016, 49 Facebook posts (2.3 posts/month) were sent compared to 2282 posts (81.5 posts/month) sent between November 2016 and February 2019. All Facebook metrics significantly increased, including impressions (mean 5475.9, SD 5483.0 vs mean 8506.1, SD 13,113.9; P<.001), engagements (mean 119.3, SD 194.8 vs mean 283.8, SD 733.8; P<.001), and reach (mean 2266.6, SD 2388.3 vs mean 5344.1, SD 8399.2; P<.001). Weekend Facebook posts had significantly more impressions per post (mean 7967.9, SD 9901.0 vs mean 9737.8, SD 19,013.4; P=.03) and a higher total reach (mean 4975.8, SD 6309.8 vs mean 6108.2, SD 12,219.7; P=.03) than weekday posts.

CONCLUSIONS

Social media has been established as a crucial tool for the propagation of neurosurgical research and education. Implementation of the JNSPG specialized SMT had a demonstrable impact on increasing the online visibility of social media content.