bluuebunny/crossref_metadata_2025 huggingface dataset:
Recurrent UBE3C-LRP5 translocations in head and neck cancer with therapeutic implications
Authors: Dharavath Bhasker , Butle Ashwin , Chaudhary Akshita , Pal Ankita , Desai Sanket , Chowdhury Aniket , Thorat Rahul , Upadhyay Pawan , Nair Sudhir , Dutt Amit
Published: March 2024

Head and neck cancer is a major cause of morbidity and mortality worldwide. The identification of genetic alterations in head and neck cancer may improve diagnosis and treatment outcomes. In this study, we report the identification and functional characterization of UBE3C-LRP5 translocation in head and neck cancer. Our whole transcriptome sequencing and RT-PCR analysis of 151 head and neck cancer tumor samples identified the LRP5-UBE3C and UBE3C-LRP5 fusion transcripts in 5.3% of patients of Indian origin (n = 151), and UBE3C-LRP5 fusion transcripts in 1.2% of TCGA-HNSC patients (n = 502). Further, whole genome sequencing identified the breakpoint of UBE3C-LRP5 translocation. We demonstrate that UBE3C-LRP5 fusion is activating in vitro and in vivo, and promotes the proliferation, migration, and invasion of head and neck cancer cells. In contrast, depletion of UBE3C-LRP5 fusion suppresses the clonogenic, migratory, and invasive potential of the cells. The UBE3C-LRP5 fusion activates the Wnt/β-catenin signaling by promoting nuclear accumulation of β-catenin, leading to upregulation of Wnt/β-catenin target genes, MYC, CCND1, TCF4, and LEF1. Consistently, treatment with the FDA-approved drug, pyrvinium pamoate, significantly reduced the transforming ability of cells expressing the fusion protein and improved survival in mice bearing tumors of fusion-overexpressing cells. Interestingly, fusion-expressing cells upon knockdown of CTNNB1, or LEF1 show reduced proliferation, clonogenic abilities, and reduced sensitivity to pyrvinium pamoate. Overall, our study suggests that the UBE3C-LRP5 fusion is a promising therapeutic target for head and neck cancer and that pyrvinium pamoate may be a potential drug candidate for treating head and neck cancer harboring this translocation.
Regulation of developmental gatekeeping and cell fate transition by the calpain protease DEK1 in Physcomitrium patens
Authors: Demko Viktor , Belova Tatiana , Messerer Maxim , Hvidsten Torgeir R. , Perroud Pierre-François , Ako Ako Eugene , Johansen Wenche , Mayer Klaus F. X. , Olsen Odd-Arne , Lang Daniel
Published: March 2024

Calpains are cysteine proteases that control cell fate transitions whose loss of function causes severe, pleiotropic phenotypes in eukaryotes. Although mainly considered as modulatory proteases, human calpain targets are directed to the N-end rule degradation pathway. Several such targets are transcription factors, hinting at a gene-regulatory role. Here, we analyze the gene-regulatory networks of the moss Physcomitrium patens and characterize the regulons that are misregulated in mutants of the calpain DEFECTIVE KERNEL1 (DEK1). Predicted cleavage patterns of the regulatory hierarchies in five DEK1-controlled subnetworks are consistent with a pleiotropic and regulatory role during cell fate transitions targeting multiple functions. Network structure suggests DEK1-gated sequential transitions between cell fates in 2D-to-3D development. Our method combines comprehensive phenotyping, transcriptomics and data science to dissect phenotypic traits, and our model explains the protease function as a switch gatekeeping cell fate transitions potentially also beyond plant development.
LncRNA-SNHG5 mediates activation of hepatic stellate cells by regulating NF2 and Hippo pathway
Authors: Zhang Rongrong , Zhan Yating , Lang Zhichao , Li Yifei , Zhang Weizhi , Zheng Jianjian
Published: March 2024

Long noncoding RNA small nucleolar RNA host gene 5 (SNHG5) is an oncogene found in various human cancers. However, it is unclear what role SNHG5 plays in activating hepatic stellate cells (HSCs) and liver fibrosis. In this study, SNHG5 was found to be upregulated in activated HSCs in vitro and in primary HSCs isolated from fibrotic liver in vivo, and inhibition of SNHG5 suppressed HSC activation. Notably, Neurofibromin 2 (NF2), the main activator for Hippo signalling, was involved in the effects of SNHG5 on HSC activation. The interaction between SNHG5 and NF2 protein was further confirmed, and preventing the combination of the two could effectively block the effects of SNHG5 inhibition on EMT process and Hippo signaling. Additionally, higher SNHG5 was found in chronic hepatitis B patients and associated with the fibrosis stage. Altogether, we demonstrate that SNHG5 could serve as an activated HSCs regulator via regulating NF2 and Hippo pathway.
Notable shifts beyond pre-industrial streamflow and soil moisture conditions transgress the planetary boundary for freshwater change
Authors: Porkka Miina , Virkki Vili , Wang-Erlandsson Lan , Gerten Dieter , Gleeson Tom , Mohan Chinchu , Fetzer Ingo , Jaramillo Fernando , Staal Arie , te Wierik Sofie , Tobian Arne , van der Ent Ruud , Döll Petra , Flörke Martina , Gosling Simon N. , Hanasaki Naota , Satoh Yusuke , Müller Schmied Hannes , Wanders Niko , Famiglietti James S. , Rockström Johan , Kummu Matti
Published: March 2024

Human actions compromise the many life-supporting functions provided by the freshwater cycle. Yet, scientific understanding of anthropogenic freshwater change and its long-term evolution is limited. Here, using a multi-model ensemble of global hydrological models, we estimate how, over a 145-year industrial period (1861–2005), streamflow and soil moisture have deviated from pre-industrial baseline conditions (defined by 5th–95th percentiles, at 0.5° grid level and monthly timestep over 1661–1860). Comparing the two periods, we find an increased frequency of local deviations on ~45% of land area, mainly in regions under heavy direct or indirect human pressures. To estimate humanity’s aggregate impact on these two important elements of the freshwater cycle, we present the evolution of deviation occurrence at regional to global scales. Annually, local streamflow and soil moisture deviations now occur on 18.2% and 15.8% of global land area, respectively, which is 8.0 and 4.7 percentage points beyond the ~3 percentage point wide pre-industrial variability envelope. Our results signify a substantial shift from pre-industrial streamflow and soil moisture reference conditions to persistently increasing change. This indicates a transgression of the new planetary boundary for freshwater change, which is defined and quantified using our approach, calling for urgent actions to reduce human disturbance of the freshwater cycle.
Direct sulfur-containing compound speciation in crude oils and high-boiling fractions by APCI (+) FT-ICR mass spectrometry
Authors: Franco Danielle Mitze Muller , Covas Taynara Rodrigues , Pereira Rosana Cardoso Lopes , da Silva Lidya Cardozo , Rangel Mario Duncan , Simas Rosineide Costa , Dufrayer Gabriel Henry Morais , Vaz Boniek Gontijo
Published: March 2024

In this study, we focus on advancing the methodology for detecting sulfur-containing compounds (SCCs) in crude oils and their derivatives.
A NiFe PBA/AuNPs nanocomposite sensitive immunosensor for electrochemical detection of PSA
Authors: Hua Xin , Zhao Tongxiao , Gui Xueqin , Jin Baokang
Published: March 2024

Due to the good biological affinity of AuNPs for biomolecules, as well as the porous nanostructure and regular shape of NiFe PBA, as well as the porous nanostructure and regular shape of NiFe PBA, NiFe PBA/AuNPs nanocomposites achieve sensitive sensor determination of PSA.
Ultrasensitive fluorometric determination of aluminum using the CoFe2O4 NPs/SDS/oxine system with the aid of ultrasound waves
Authors: Alqahtani Yahya S. , Mahmoud Ashraf M. , El-Wekil Mohamed M.
Published: March 2024

In this study, we present a thoughtful integration of a dispersive solid-phase sorbent and oxine for the ultrasensitive and highly selective determination of Al3+ ions.
Application of a meshed artificial dermal scaffold and negative-pressure wound therapy in the treatment of full-thickness skin defects: a prospective in vivo study
Authors: Wei Pei , Wu Lijiao , Xie Hongteng , Chen Zhaohong , Tan Rongwei , Xu Zhaorong
Published: March 2024

A novel meshed ADS combined with NPWT can reduce the risk of scaffold-related complications, which helps to improve the quality of wound repair and promotes a broader range of applications.
Sulfur poisoning and NH3 regeneration of Pt/Al2O3: oxidations of SO2, NH3, NO and C3H6 as probe reactions
Authors: Fang Chenhao , Harold Michael P.
Published: March 2024

The impact of SOx (x = 2, 3) on the activity of a model diesel oxidation catalyst (DOC: Pt/Al2O3) is examined for the oxidations of sulfur dioxide (SO2), nitric oxide (NO), and propylene (C3H6).
Doped carbon dots affect heavy metal speciation in mining soil: changes of dissimilated iron reduction processes and microbial communities
Authors: Huang Xinyi , Liu Shaobo , Liu Xuanming , Tan Xiaofei , Guo Shuai , Dai Mingyang , Chen Qiang , Chen Gaobin , Feng Chenzhi
Published: March 2024

Carbon dots (CDs) inevitably accumulate in soils due to their widespread use, affecting soil enzyme activities and microbial community structure.
Influence of time and ageing conditions on the properties of ferrihydrite
Authors: Sassi Michel , Qafoku Odeta , Bowden Mark E. , Pearce Carolyn I. , Latta Drew , Miller Quin R. S. , Boamah Mavis D. , N'Diaye Alpha T. , Holliman Jr. Jade E. , Arenholz Elke , Rosso Kevin M.
Published: March 2024

Storage conditions affect the initial tetrahedral iron and hydroxyl populations of ferrihydrite, both are correlated and decrease over time as function of ageing.
Genotype and ripening method affect carotenoid content and bio-accessibility in banana
Authors: Munoz Bryan , Hayes Micaela , Perkins-Veazie Penelope , Gillitt Nicholas , Munoz Miguel , Kay Colin D. , Lila Mary Ann , Ferruzzi Mario G. , Iorizzo Massimo
Published: March 2024

This study concludes that the genotype, ripening methods (natural vs. exogenous ethylene application), and carotenoid bioaccessible content should be considered when setting a nutrition goal for vitamin A biofortification in banana-breeding programs.
Polysaccharide fromPleurotus tuber-regiummycelium improves DSS-induced colitis in mice by regulating inflammatory cytokines, oxidative stress and gut microbiota
Authors: Mo Cuiyuan , Liu Ruofan , Yang Zhenhua , Ma Aimin
Published: March 2024

Pleurotus tuber-regium(PTR) has been proved to have obvious pharmacological properties.
Fluorescent covalent organic frameworks – promising bioimaging materials
Authors: Karthik Chimatahalli Santhakumar , Skorjanc Tina , Shetty Dinesh
Published: March 2024

Fluorescent covalent organic frameworks (COFs) are promising candidates for imaging living cells due to their unique properties. Herein, we critically reviewed the progress and structure–activity relations of COFs for the effective bioimaging.
Construction of a binder-free PANI-CQD-Cu electrode via an electrochemical method for flexible supercapacitor applications
Authors: Shanmugasundaram Esakkimuthu , Ganesan Vigneshkumar , Narayanan Vimalasruthi , Vellaisamy Kannan , Saleh Na'il , Thambusamy Stalin
Published: March 2024

In recent years, flexible hybrid supercapacitors (FSCs) have played a significant role in energy storage applications owing to their superior flexibility and electrochemical properties.
Uncovering thermally activated purple-to-blue luminescence in Co-modified MgAl-layered double hydroxide
Authors: Gevers Bianca R. , Roduner Emil , Leuteritz Andreas , Labuschagné Frederick J. W. J.
Published: March 2024

Co-modified nano-sandrose layered double hydroxide containing 15 mol% Co shows thermally-activated luminescence in the purple-to-blue visible-light region at room temperature.
Zeolitic imidazolate framework-90 loaded with methylprednisolone sodium succinate effectively reduces hypertrophic scarin vivo
Authors: Xu Xiaoxiang , Liu Jun , Xiao Zixuan , Li Shuang , Zhang Ya , Song Peng , Lin Kun , Zhang Lei , Zheng Haoquan , Zhou Yuye , Chen Xiong
Published: March 2024

Hypertrophic scar (HS) is characterized by an abnormal fibroblast-myofibroblast transformation; non-apoptosis of fibroblasts; and redundant expression of TGF-β1, VEGF, α-SMA, and collagen I/III.
Defect-engineered WSxSe2−x nanocrystals anchored on selenized polyacrylonitrile fibers toward high-performance sodium/potassium-ion batteries with a wide working temperature range
Authors: Xiao Fuyu , Zhang Jingran , Zhou Weiming , Fang Yixing , He Xiaotong , Lai Wenbin , Lin Chuyuan , Ge Mingyang , Fan Haosen , Qian Qingrong , Wei Mingdeng , Chen Qinghua , Zeng Lingxing
Published: March 2024

WSSe-Se@PAN was fabricated by the electrospinning route combined with selenization treatment. It exhibited a wide working temperature range for SIB/PIB applications.
Tuning thermal and graphitization behaviors of lignin via complexation with transition metal ions for the synthesis of multilayer graphene-based materials
Authors: Yan Qiangu , Zhang Hanwen , Ketelboeter Timothy , Peng Yucheng , Wan Caixia , Cai Zhiyong
Published: March 2024

Transition metals affect thermal stabilization and graphitization of kraft lignin and further determine morphology and graphitic structures of multilayer graphene-based materials.
Electrospun Cu–Co ferrite nanofibers: synthesis, structure, optical and magnetic properties, and anti-cancer activity
Authors: Alahmari Fatimah , Khan Firdos Alam , Sozeri H. , Sertkol M. , Jaremko Mariusz
Published: March 2024

In this study, we investigated Cu–Co ferrite nanofibers (NFs) that were synthesized for the first time employing the electrospinning technique.
Pioneering dielectric materials of Sn-doped Nb0.025Ti0.975O2 ceramics with excellent temperature and humidity stability for advanced ceramic capacitors
Authors: Mingmuang Yasumin , Chanlek Narong , Takesada Masaki , Swatsitang Ekaphan , Thongbai Prasit
Published: March 2024

The dielectric properties exhibit excellent stability across a wide range of temperatures. Additionally, the capacitance is almost exclusively dependent on humidity levels.
Magnetic MnFe2O4/ZIF-67 nanocomposites with high activation of peroxymonosulfate for the degradation of tetracycline hydrochloride in wastewater
Authors: Lu Si , You Sasha , Hu Junhao , Li Xiang , Li Ling
Published: March 2024

Schematic illustration of the reaction mechanisms in the MnFe2O4/ZIF-67/PMS system.
Design and synthesis of ammonia-modified reduced graphene oxide possessing more amino groups for methylene blue adsorption
Authors: Wang Chubei , Zhou Jianwei , Duo Fangfang , Chu Liangliang , Zhang Mingliang , Xu Chao , Zhao Yanwei , Liu Shuai , Li Sitian
Published: March 2024

To obtain a high-performance functional graphene with more amino groups, chlorine-functionalized reduced graphene oxide (RGO) reacts with ammonia.
The use of deep eutectic solvents as a promising approach in the design of microwave-based green gas sensors
Authors: Bertrand Emilie , Himdi Mohamed , Rondeau David , Castel Xavier , Delhaye Thomas , Paquin Ludovic
Published: March 2024

Highlighting the use of deep eutectic solvent (DES) as the sensitive material of a new sustainable microwave gas sensor through the development of a simple and low-cost device sensitive to hydrogen chloride.
Understanding the phase stability of yttria stabilized zirconia electrolyte under solid oxide electrolysis cell operation conditions
Authors: Kim Seong Kyun , Lee Hyeon Jin , Moon Jin Young , Jo Yong-Ryun , Lee Jinsil , Park Ji-Hoon , Kim Sun-Dong , Joo Jong Hoon
Published: March 2024

The degradation mechanism of yttria-stabilized zirconia (YSZ) with varying Y2O3 compositions under an applied electric potential.
Composite anode for fluoride-ion batteries using alloy formation and phase separation in charge and discharge processes
Authors: Nakayama Kei , Miki Hidenori , Nakagawa Takashi , Noi Kousuke , Sugawara Yoshihiro , Kobayashi Shunsuke , Sakurai Katsutoshi , Iba Hideki , Kuwabara Akihide , Ikuhara Yuichi , Abe Takeshi
Published: March 2024

For fluoride-ion batteries, (In + LaF3-based material) anodes are proposed, and reversible alloy formation during charge and discharge is demonstrated. Such formation helps shift the redox potentials of anodes to prevent electrolyte decomposition.
Remote p–d orbital hybridization via first/second-layer coordination of Fe single atoms with heteroatoms for enhanced electrochemical CO2-to-CO reduction
Authors: Yang Ying , Chen Lizhen , Guo Zhenyan , Liu Shengqi , Wu Pei-dong , Fang Zhen , Zhang Kai , Li Hu
Published: March 2024

d–p orbital hybridization induced by S/N in the coordination layer of pyrrole-type Fe–N4 can modulate the electronic structure of Fe single atoms, enabling *COOH adsorption and *CO desorption to exclusively furnish CO but suppressing H2 formation.
Evaluation of gelatin-based hydrogels for colon and pancreas studies using 3D in vitro cell culture
Authors: Pamplona Regina , González-Lana Sandra , Ochoa Ignacio , Martín-Rapún Rafael , Sánchez-Somolinos Carlos
Published: March 2024

GelMA-based hydrogels with tunable stiffness through two crosslinking strategies and diverse swelling behavior, are evaluated as potential 3D models for CRC and pancreatic cancer. Stiffness and composition influence cell proliferation and migration.
Magnetic transitions of biphenylene network layers induced by external perturbations
Authors: Kim Sejoong
Published: March 2024

We present a comprehensive investigation of the magnetic ordering in biphenylene network (BPN) layers, employing density functional theory (DFT) calculations under external perturbations, including uniaxial strains and hole doping.
In situ growth of Cs3Bi2Br9 on ultrathin BiVO4 nanosheets to fabricate heterojunction intimate interfaces for enhancing photocatalytic activity
Authors: Gao Yingdan , Guo Yurong , Zhao Guangjiu
Published: March 2024

An intriguing Cs3Bi2Br9/BiVO4 S-scheme heterojunction was fabricated by in situ growth of Cs3Bi2Br9 perovskite on BiVO4 NSs for the first time. This work provides an insight for effectively improving the photocatalytic performance in visible light.
Nanomaterial-based probes for iodide sensing: synthesis strategies, applications, challenges, and solutions
Authors: Mansha Muhammad , Abbas Noreen , Altaf Faizah , Khan Safyan Akram , Khan Ibrahim , Ali Shahid
Published: March 2024

Nanomaterial-based sensors have emerged as promising candidates for iodide ion sensing owing to their unique properties, such as high surface area, tunable surface chemistry, and excellent electrical/optical characteristics.
Vertical organic electrochemical transistor platforms for efficient electropolymerization of thiophene based oligomers
Authors: Gryszel Maciej , Byun Donghak , Burtscher Bernhard , Abrahamsson Tobias , Brodsky Jan , Simon Daniel Theodore , Berggren Magnus , Glowacki Eric Daniel , Strakosas Xenofon , Donahue Mary Jocelyn
Published: March 2024

Vertical organic electrochemical transistor platforms enable facile channel formation by electropolymerization. The improved deposition control and resulting high performance is demonstrated here with the trimer ETE-COONa.
Precipitation enhancement of liquid thermoelectric conversion with Fe(ClO4)2/Fe(ClO4)3 dissolved in DMF
Authors: Wake Akihiro , Inoue Dai , Moritomo Yutaka
Published: March 2024

Oxidant precipitation in the electrolyte significantly enhances the open circuit voltage and output power in a liquid thermoelectric conversion device.
Optical properties enhancement via WSSe/silicene solar cell junctions
Authors: Pedrosa Renan Narciso , Villegas Cesar E. P. , Rocha A. R. , Amorim Rodrigo G. , Scopel Wanderlã L.
Published: March 2024

A Janus–silicene heterojunction as a potential candidate for solar cell applications.
A highly stable Pr2NiO4+δ oxygen electrode in electrolyte supported protonic ceramic electrolysis cells (PCECs) for hydrogen production with high faradaic efficiency
Authors: Schley Leon , Vibhu Vaibhav , Nohl Lucy , Vinke Izaak C. , de Haart L. G. J. (Bert) , Eichel Rüdiger-A.
Published: March 2024

This study investigates the faradaic efficiency in BaCe0.7Zr0.1Y0.1Yb0.1O3−δ electrolyte supported protonic ceramic electrolysis cells (PCECs). Furthermore, excellent durability is demonstrated with a Pr2NiO4+δ oxygen electrode.
Ionic liquid post-modified carboxylate-rich MOFs for efficient catalytic CO2 cycloaddition under solvent-free conditions
Authors: Bao Wen-Li , Kuai Jie , Gao Hai-Yang , Zheng Meng-Qi , Sun Zhong-Hua , He Ming-Yang , Chen Qun , Zhang Zhi-Hui
Published: March 2024

Ionic liquid post-modified carboxylate-rich MOFs, which were synthesized and characterized, are highly efficient for catalytic epoxides and CO2 cycloaddition under solvent-free conditions.
A twist for tunable electronic and thermal transport properties of nanodevices
Authors: Ostovan Azar , Milowska Karolina Z. , García-Cervera Carlos J.
Published: March 2024

A twist-driven switching phenomenon in low-twist nanodevices based on zigzag graphene. Nanoribbons with [6,3]-flake.
Catalyst-free visible light-promoted defunctionalization of alkyl isocyanides with a hydrosilane through C–N bond cleavage
Authors: Ma Yu-Qing , Tian Shi-Kai
Published: March 2024

Various alkyl isocyanides participated in the defunctionalization with tris(trimethylsilyl)silane under blue light irradiation at room temperature with high chemoselectivity.
Innovative snail-mucus-extract (SME)-coated nanoparticles exhibit anti-inflammatory and anti-proliferative effects for potential skin cancer prevention and treatment
Authors: Valeria Consoli , Salvatore Petralia , Luca Vanella , Maria Gulisano , Ludovica Maugeri , Cristina Satriano , Lucia Montenegro , Angela Castellano , Valeria Sorrenti
Published: March 2024

Nowadays, several studies have highlighted the ability of snail mucus in maintaining healthy skin conditions due to its emollient, regenerative and protective properties.
Novel sulfonamide derivatives as multitarget antidiabetic agents: design, synthesis, and biological evaluation
Authors: Ayoup Mohammed Salah , Khaled Nourhan , Abdel-Hamid Hamida , Ghareeb Doaa A. , Nasr Samah A. , Omer Ahmed , Sonousi Amr , Kassab Asmaa E. , Eltaweil Abdelazeem S.
Published: March 2024

A series of new sulfonamide derivatives connected through an imine linker to five or seven membered heterocycles were designed and synthesized.
Correction: Synthesis and anticancer evaluation of [d-Ala]-nocardiotide A
Authors: Maharani Rani , Muhajir Muhamad Imam , Dirgantara Jelang Muhammad , Hardianto Ari , Mayanti Tri , Harneti Desi , Nurlelasari  , Farabi Kindi , Hidayat Ace Tatang , Supratman Unang , Siahaan Teruna
Published: March 2024

Correction for ‘Synthesis and anticancer evaluation of [d-Ala]-nocardiotide A’ by Rani Maharani et al., RSC Adv., 2024, 14, 4097–4104, https://doi.org/10.1039/D4RA00025K.
A multicomponent reaction for modular assembly of indole-fused heterocycles
Authors: Li Jiaming , Ni Hao , Zhang Weiwei , Lai Zhencheng , Jin Huimin , Zeng Linwei , Cui Sunliang
Published: March 2024

A multicomponent reaction for modular assembly of indole-fused seven-membered heterocycles is reported. This protocol featured simple starting materials, mild reaction conditions and broad substrate scope, and is synthetically useful.
Organic piezocatalyst polyimide: molecular structure tailoring and robust built-in electric field
Authors: Zhang Yan , Liu Jingang , Hu Cheng , Zhi Xinxin , Pan Zhen , Yu Hongjian , Han Jie , Huang Hongwei
Published: March 2024

A linear-structure polyimide with an enhanced molecular dipole was obtained by molecular structure tailoring, which has enhanced built-in electric field and was first utilized for efficient piezocatalytic degradation of organic pollutants.
Stimuli-responsive circularly polarized luminescence with chiroptical amplification and inversion enabled by cholesterically assembled bio-materials
Authors: Miao Qing , Wang Xi , Jin Bowen , Chen Yang , Zhou Yi , Xiong Rui , Meng Xiao , Ye Chunhong
Published: March 2024

CPL active materials with a tunable glum-factor, from −0.30 to 0.04, were fabricated by incorporating responsive organic dye into cellulose nanocrystals. Such films showed dynamic switchable CPL signal in intensity and handedness at different pH.
Imaging the event horizon of M87* from space on different timescales
Authors: Shlentsova A. , Roelofs F. , Issaoun S. , Davelaar J. , Falcke H.
Published: March 2024

Context. The concept of a new space very long baseline interferometry (SVLBI) system named the Event Horizon Imager (EHI) has been proposed to dramatically improve black hole imaging and provide precise tests of the theory of general relativity.

Aims. This paper presents imaging simulations for the EHI. We investigate the ability to make high-resolution movies of the black hole shadow and jet launching region around the supermassive black hole M87* and other black hole jets with a three-satellite EHI configuration. We aim to identify orbital configurations to optimize the uυ-coverage to image variable sources.

Methods. Observations of general relativistic magnetohydrodynamics (GRMHD) models were simulated for the configuration, consisting of three satellites in circular medium earth orbits with an orbital plane perpendicular to the line of sight. The expected noise was based on preliminary system parameters. Movie frames, for which a part of the uυ-coverage may be excessively sparse, were reconstructed with algorithms that recover missing information from other frames. Averaging visibilities accumulated over multiple epochs of observations with an appropriate orbital configuration then improves the image quality. With an enhanced signal-to-noise ratio, timescales of observed variability were decreased.

Results. Our simulations show that the EHI with standard system parameters is capable of imaging the variability in the M87* environment on event horizon scales with approximately a month-long temporal resolution. The EHI with more optimistic noise parameters (enhancing the signal-to-noise ratio about 100-fold) would allow for imaging of the variability on gravitational timescales. Observations with an EHI setup at lower frequencies are capable of imaging the variability in extended jets.

Conclusions. Our study shows that the EHI concept can be used to image the variability in a black hole environment and extended jets, allowing for stronger tests of gravity theories and models of black hole accretion, plasma dynamics, and jet launching.
The cold interstellar medium of a normal sub-L⋆ galaxy at the end of reionization
Authors: Valentino F. , Fujimoto S. , Giménez-Arteaga C. , Brammer G. , Kohno K. , Sun F. , Kokorev V. , Bauer F. E. , Di Cesare C. , Espada D. , Lee M. , Dessauges-Zavadsky M. , Ao Y. , Koekemoer A. M. , Ouchi M. , Wu J. F. , Egami E. , Jolly J.-B. , Lagos C. del P. , Magdis G. E. , Schaerer D. , Shimasaku K. , Umehata H. , Wang W.-H.
Published: March 2024

We present the results of a ∼60-h multiband observational campaign with the Atacama Large Millimeter Array targeting a spectroscopically confirmed and lensed sub-L⋆ galaxy at z = 6.07, first identified during the ALMA Lensing Cluster Survey (ALCS). We sampled the dust continuum emission from rest frame 90–370 μm at six different frequencies and set constraining upper limits on the molecular gas line emission and content by targeting the CO (7 − 6) and [C I](3P2−3P1) transitions in two lensed images with μ ≳ 20. Complementing these submillimeter observations with deep optical and near-IR photometry and spectroscopy with JWST, we find this galaxy to form stars at a rate of SFR ∼ 7 M⊙ yr−1, ∼50 − 70% of which is obscured by dust. This is consistent with what one would predict for a M⋆ ∼ 7.5 × 108 M⊙ object by extrapolating the relation between the fraction of the obscured star formation rate and stellar mass at z <  2.5 and with observations of IR-detected objects at 5 <  z <  7. The light-weighted dust temperature of Tdust ∼ 50 K is similar to that of more massive galaxies at similar redshifts, although with large uncertainties and with possible negative gradients. We measure a dust mass of Mdust ∼ 1.5 × 106 M⊙ and, by combining [C I], [C II], and a dynamical estimate, a gas mass of Mgas ∼ 2 × 109 M⊙. Their ratio (δDGR) is in good agreement with predictions from models and empirical relations in the literature. The dust-to-stellar mass fraction of fdust ∼ 0.002 and the young stellar age (100 − 200 Myr) are consistent with efficient dust production via supernovae, as predicted by existing models and simulations of dust evolution. Also, the expected number density of galaxies with Mdust ∼ 106 M⊙ at z = 6 from a subset of these models is in agreement with the observational estimate that we set from the parent ALCS survey. The combination of gravitational lensing and deep multiwavelength observations allowed us to probe luminosity and mass regimes up to two orders of magnitude lower than what has been explored so far for field galaxies at similar redshifts. Our results serve as a benchmark for future observational endeavors of the high-redshift and faint sub-L⋆ galaxy population that might have driven the reionization of the Universe.
Individual chaotic behaviour of the S-stars in the Galactic centre
Authors: Beckers Sam J. , Poppelaars Colin M. , Ulibarrena Veronica S. , Boekholt Tjarda C. N. , Portegies Zwart Simon F.
Published: March 2024

Located at the core of the Galactic centre, the S-star cluster serves as a remarkable illustration of chaos in dynamical systems. The long-term chaotic behaviour of this system can be studied with gravitational N-body simulations. By applying a small perturbation to the initial position of star S5, we can compare the evolution of this system to its unperturbed evolution. This results in two solutions that diverge exponentially, defined by the separation in position space δr, with an average Lyapunov timescale of ∼420 yr, corresponding to the largest positive Lyapunov exponent. Even though the general trend of the chaotic evolution is governed in part by the supermassive black hole Sagittarius A∗ (Sgr A∗), individual differences between the stars can be noted in the behaviour of their phase-space curves. We present an analysis of the individual behaviour of the stars in this Newtonian chaotic dynamical system. The individuality of their behaviour is evident from offsets in the position space separation curves of the S-stars and the black hole. We propose that the offsets originate from the initial orbital elements of the S-stars, where Sgr A∗ is considered in one of the focal points of the Keplerian orbits. Methods were considered to find a relation between these elements and the separation in position space. Symbolic regression provides the clearest diagnostics for finding an interpretable expression for the problem. Our symbolic regression model indicates that ⟨δr⟩ ∝ e2.3, implying that the time-averaged individual separation in position space increases rapidly with the initial eccentricity of the S-stars.
Acheter une caméra hyperspectrale FTIR pour des mesures environnementales et signatures infrarouges
Authors: Dumont Antoine
Published: March 2024

Les caméras hyperspectrales infrarouges par transformée de Fourier (FTIR) permettent de combiner l’information spatiale et spectrale de façon inégalée. Ces instruments ont leur place autant dans un laboratoire que sur le terrain et offrent une solution élégante à grande précision pour une grande gamme d’applications
Establishment of diagnostic reference level for routine CT scan examination in Sokoto state, Nigeria
Authors: Kabeer S.M. , Aliyu S.A. , Umar F.K. , Kamal I. , Murat H. , Muhammad N.A. , Karim M.K.A
Published: March 2024

Diagnostic Reference Levels (DRLs) are embedded into the optimization procedure to regulate CT dose and diagnostic quality. The purpose of this research was to establish the local DRLs and radiation dose exposure for CT scans at the Sokoto State Advanced Medical Diagnostic Center, Nigeria. 190 patients who had CT head, chest, and abdomen-pelvis scans were collected and evaluated for this study. It was established that the DRLs for CTDIvol for the head, thorax, and abdomen-pelvis were 48.2, 9.44, and 8.02, respectively with DLP DRLs in mGy.cm were 1044, 372, and 646. When comparing head CTs, our CTDIvol DRL is lower than many international standards, yet our DLP DRL is also below those of other nations. The chest CT DRL from Sokoto state is comparable to the DLP standards of some nations, although its CTDIvol is higher. The abdomen-pelvis CTDIvol DRLs are lower than those of the UK and US, thus necessitating the implementation of a controlled and optimized protocol in order to guarantee patient safety while maintaining image quality.
Research on the Design of Museum Cultural and Creative Products under the background of new cultural and Creative culture
Authors: Zhou Chengjun , Han Zixuan
Published: March 2024

This paper discusses the design of museum cultural and creative products under the background of new cultural and creative culture. Through the interpretation of related concepts of new cultural and creative products, from the aspects of its content and products combined with the current development of museum cultural and creative products, summed up the design principles of museum cultural and creative products. While interpreting the relevant design principles, this paper designs cultural and creative products by combining the cultural relics collected by several museums in Hubei Province, and provides feasible and constructive ideas and methods for the design of cultural and creative products in museums by combining theory with practice.
Application Research on Integrating Digital Garden Culture into Exhibition Space Design of Science and Technology Museum
Authors: Zhang Jiarui
Published: March 2024

Explore how technology museums can integrate interactive garden culture to promote sustainability and environmental protection. Pay special attention to how virtual reality technology integrates with garden culture to create a unique exhibition experience that interacts with nature. In addition, conduct in-depth research on how interactive garden culture can enhance the participation and learning experience of museum visitors. One of the focuses of research is how to enhance the effectiveness of interactive garden culture through multi-sensory experiences and emotional interactions in museum exhibitions. Finally, we will explore how digital gardens can promote cultural interaction and participatory design to enrich the content and experience of museum exhibitions.
The insurrection of Northwest China during the 270s: The chaos due to the inappropriate political system
Authors: Xing Cheng
Published: March 2024

The war of Qinliang area (located in today’s Gansu Province, China) was an important historical event of the Western Jin Dynasty (265-317). In Chinese history, it was called the insurrection of Qinliang area. The insurgency of Hexi Sumbe’s leader named Tufa Shujineng (?-279) greatly delayed the end of Three Kingdoms Period (220-280). From 270 to 279, more than one hundred thousand soldiers of Western Jin Dynasty were sent to the battle field. Four generals were killed by the army of Tufa. However, the mutiny was finally end by general Ma Long (?-?) and his little army (consisted of 3500 soldiers).
Navigating Identity: The Intersectional and Postcolonial Feminist Perspective on Immigrant Women’s Dilemmas
Authors: Zhao Heshan
Published: March 2024

This investigation delves into the intricate web of identity crises faced by immigrant women, viewed through the dual lenses of intersectionality and postcolonial feminism. The paper posits that the confluence of race, class, gender, and legal status creates unique challenges that often go unnoticed in the broader narrative on immigration. It dissects how postcolonial echoes shape present societal frameworks, highlighting the intersection with contemporary discrimination forms that exacerbate immigrant women's difficulties. The exploration includes their navigation of societal expectations, cultural dissonance, and their frequently unrecognized labor contributions, revealing a complex array of identity struggles that defy easy classification. By articulating these issues, this research seeks to elevate the discourse surrounding immigrant women, advocating for policy initiatives and societal acknowledgment that resonate with the nuanced intersectional reality of their existence. The aim is not merely to analyze but to forge pathways for empowerment and recognition, crafting a narrative that fully appreciates the rich mosaic of immigrant women’s identities and experiences.
The Creation of Guideline for Development Private Music School Business
Authors: Sun Dingjie , Phokha Pramote
Published: March 2024

A very serious epidemic broke out in China at the beginning of 2020, and the market's economic environment was greatly affected. As a branch of the education and training industry, private music schools have also been hit hard. After all, the education and training industry supports operations through advanced collections, but the epidemic has led to a serious increase in class consumption data for many important indicators. On the one hand, it is worsening due to the inability to recruit new students. On the other hand, the overall data on class consumption is no longer growing. At the same time, when the rent and labor costs remain unchanged, most institutions in the education and training industry are in varying degrees. Losses, the main research of this article is from what angle can the private education industry make breakthroughs in the three years since the establishment of the epidemic and the implementation of the double reduction policy? Can some problems in operation and management during the epidemic be solved through bleaching, combined with the implementation of national policies that have once again passed reforms to better adapt to future industry development?
An Analysis of Bernardo Bertolucci’s The Dreamers from a Symbolist Perspective
Authors: Dai Yutong
Published: March 2024

Bernardo Bertolucci’s The Dreamers, adapted from the novel The Holy Innocents by Gilbert Adair, is set against the backdrop of Events of May 1968 in Paris, though without making much visible effort to reconstruct the look of the period. This paper attempts to analyze the character behavior of The Dreamers from the perspective of Freudian psychoanalysis and explore the ideology and culture represented by Isabella, Theo, and Matthew from the perspective of symbolism, with the interperation of the story background and metaphor of the whole film.
Script Analysis and Directorial Concept in the Realm of Drama and Film
Authors: Yang Ying , Qin Ke
Published: March 2024

This academic article ventures into the complex and nuanced world of script analysis and directorial conceptualization in drama and film, shedding light on their significant impact on the creation and interpretation of cinematic works. It delves into how a script serves not only as a narrative blueprint but also as a springboard for creative exploration, allowing directors to infuse their unique artistic visions. The article examines the multifaceted process of script breakdown, character development, and thematic exploration, highlighting how directors interpret and adapt written narratives to the screen. It explores the symbiotic relationship between the written word and visual storytelling, emphasizing how directors' choices in cinematography, casting, and production design contribute to the overall narrative and emotional impact of a film. Through detailed analysis of case studies and directorial techniques, this study aims to reveal the intricate interplay between script and screen, offering insights into the transformative journey from script to cinematic masterpiece.
Long-term course of untreated asymptomatic esophageal eosinophilia and minimally symptomatic eosinophilic esophagitis
Authors: Abe Yasuhiko , Kikuchi Ryosuke , Sasaki Yu , Mizumoto Naoko , Yagi Makoto , Onozato Yusuke , Watabe Takahiro , Goto Hiroki , Miura Takahiro , Sato Ryou , Ito Minami , Tsuchiya Hiroko , Ueno Yoshiyuki
Published: March 2024

Background and study aims The long-term course of untreated asymptomatic esophageal eosinophilia (aEE) and minimally symptomatic eosinophilic esophagitis (mEoE) are not well understood. This study aimed to clarify this course.

Patients and methods A total of 36 patients with EE who were endoscopically followed up for more than 5 years, and who underwent more than one endoscopy evaluation after the first diagnosis, were investigated. These patients were divided into two groups according to the presence or absence of the continuous treatment: no treatment group (NT group, n=22) and proton pump inhibitor/potassium competitive acid blocker group (Tx group, n=14). Symptoms and endoscopic and histological findings were retrospectively reviewed according to endoscopic phenotypes. Endoscopic assessment was performed using the EoE endoscopic reference score (EREFS).

Results The median follow-up period was 84.5 months in the Tx group and 92 months in the NT group. During the follow-up period, about half of the patients in the Tx-diffuse group persisted EREFS >3, while the remaining half had EREFS ≤2. The total EREFS in the NT-diffuse group remained almost unchanged (median: 2–4) without apparent exacerbation. In contrast, EREFS in the NT-localized group exhibited an unchanged or gradually decreasing trend, with statistical significance from the first diagnosis to 72 to 83 months after.

Conclusions Untreated aEE and mEoE are not likely to worsen even without treatment at least for a median follow-up of 7 years. Instead, the localized type may spontaneously improve, implying a different pathogenesis in the presence of the diffuse type. Further studies should clarify the long-term prognosis.
Giant ICA Cavernous Aneurysm with Coarctation of Aorta and Autoimmune Hemolytic Disease Posted for Flow Diverter Stenting
Authors: Gali Yagna M. , Bhushanam Moparthi R. , Gurrala Shekhar R. , Reddy Sanna R. , Pathak Vipul
Published: March 2024

Anesthetic management of a case of intracranial aneurysm with coarctation of the aorta poses a formidable challenge to the anesthesiologist. The perioperative risks associated with such cases are rupture of an aneurysm, cardiac arrhythmias, stroke from cerebral insufficiency, intracerebral hemorrhage, myocardial ischemia, thromboembolic stroke, and aortic dissection. Endovascular stenting is preferred over surgical clipping of an aneurysm as flow diverter stenting has less morbidity and mortality compared to the latter, and the parent vessel can also be preserved. Despite the perioperative risks, successful stenting of an internal carotid artery aneurysm is beneficial in preventing impending aneurysm rupture and the progressive worsening of neurological symptoms. Therefore, it is imperative to understand the physiological basis behind the unforeseen complex hemodynamic fluctuations occurring during the procedure, as well as the anesthetic goals and complications encountered during the procedure. We describe and discuss the successful anesthetic management of a case of a giant internal carotid artery aneurysm with coarctation of the aorta and autoimmune hemolytic disease posted for flow diverter stenting.
Dupuytren's Disease: A Novel Minimally Invasive Pull-Through Technique
Authors: Maruccia Michele , Tedeschi Pasquale , Sisto Francesco , Converti Ilaria , Giudice Giuseppe , Elia Rossella
Published: March 2024

Background Dupuytren's disease decreases quality of life significantly and often requires surgical treatment, nevertheless there is no actual gold standard. The aim of this study was to introduce the use of minimally invasive pull-through technique.

Methods From 2016 to 2020, 52 patients suffering from Dupuytren's contracture were treated with the minimally invasive pull-through technique. We evaluated the improvement in range of motion, pain, disability, and quality of life in the long term. Total extension deficit, quick disabilities of the arm, shoulder, and hand (QuickDASH), and EuroQol five dimensions—five levels index were systematically scored before each surgical intervention and reevaluated after 24 months.

Results Fourteen patients (26.9%) had already received a previous intervention (percutaneous needle aponeurotomy or collagenase Clostridium histolyticum). The mean preoperative total active extension deficit was 84.0 ± 23.3 degrees (55–130 degrees). Mean follow-up was 36 months. There were no cases of tendon rupture or neurovascular injury. Total active extension deficit at the final follow-up was 3.4 ± 2.3 degrees (0–12 degrees). The mean active range of motion of the MCP and PIP joints were, respectively, 90.5 ± 3.3 degrees (85–96 degrees) and 82.7 ± 2.5 degrees (80–87 degrees). At 24 months after cord excision, a mean 10.7 points improvement in the QuickDASH questionnaire was registered (p < 0.001). Pull-through technique was equally effective both on patients with a primary or a recurrent disease. Eight patients (15.4%) had a recurrence of disease in the metacarpophalangeal joint or proximal interphalangeal joint.

Conclusion The pull-through technique is a simple, accessible, and effective technique for the treatment of Dupuytren's contracture. The use of palmar mini-incisions combined with minimal dissection has a low risk of iatrogenic injury to the neurovascular bundles and tendons, and has a low risk of recurrence rate. This study reflects level of evidence IV.
The Relationship between Soluble Angiotensin-Converting Enzyme Level and Coronavirus Disease 2019 in Children: A Prospective Cohort Study
Authors: Melek Arsoy Hacer Efnan , Elmas Bahri , Tarim Ayşe , Dervişoğlu Çavdar Pınar , Orhan Mehmet Fatih , Yazar Hayrullah
Published: March 2024

Objective Our objective was to investigate soluble angiotensin-converting enzyme (sACE) levels in pediatric patients with coronavirus disease 2019 (COVID-19) and to identify factors associated with the occurrence and severity of pediatric COVID-19.

Methods This was a prospective cohort study conducted between April 2020 and July 2020. The study population consisted of 143 children (between 1 month and 18 years old), 103 of whom had COVID-19 and 40 of whom were negative for COVID-19 (randomly selected). The sACE levels and other laboratory data of all participants were measured at admission (day 0, baseline). Repeat measurements were performed in patients on the 5th day. Disease severity was documented at baseline and on the 5th day, and the change in severity between these time points was recorded.

Results Age and sex distribution were similar in the two groups. At baseline, 31 (30.1%) of the patients were asymptomatic, 58 (56.3%) had mild disease, and 14 (13.6%) had moderate disease. Baseline sACE levels were similar in the groups (p = 0.120). Higher weight was independently associated with low sACE levels in children (p = 0.037). The sACE level of patients on the 5th day was significantly lower compared with baseline (p = 0.007). Patients who experienced a decrease in disease severity were compared with those who did not demonstrate a decrease. Baseline sACE levels were significantly lower in those who experienced decreased severity (p = 0.039). Multiple linear regression revealed that COVID-19 severity at baseline was independently associated with the low sACE level at baseline (p = 0.023).

Conclusion Lower sACE at diagnosis was associated with COVID-19 severity in children. However, no strong evidence was found that could suggest the sACE level as an important predictor for the occurrence or severity of COVID-19 in children.