bluuebunny/crossref_metadata_2025 huggingface dataset:
Ultrastructure of Anterior Lens Capsule and Epithelium in High-Myopic Cataracts
Authors: Wang Yingbin , Wu Wenjie , Cai Yajing , Yu Mengting , Zhong Xiurong , Wu Minxia
Published: April 2021

BACKGROUND: The mechanism of high-myopic cataract (HMC) is not fully understood yet. The ultrastructure of anterior lens capsule (aLC) and lens epithelial cells (LECs) may provide some clues to this issue.METHODS: Capsulorhexis samples from 10 eyes with HMC and 10 eyes with age-related cataract (ARC) were analyzed for morphologic characteristics using transmission electron microscopy (TEM).RESULTS: Several common pathologic disorders of LECs, including pleomorphic cellular structure, extensive intracellular vacuoles, swollen organelles, degeneration and necrotic lesions, could be observed in both HMC group and ARC group, to a similar extent. Specimens of HMC group disclosed remarkable extracellular spaces, interdigitation of LECs as well as protuberances of aLC towards LECs. CONCLUSIONS: The ultrastructure of aLC and LECs in HMC demonstrated some specific pathologic disorders in comparison with ARC, which might play a role in the formation of cataract in high myopes.
Curcumol inhibits malignant biological behaviors and TMZ-resistance of glioma cells via reducing long noncoding RNA FoxD2-As1 promoted EZH2 activation
Authors: Lv Xuyang , Sun Jiangchuan , Hu Linfeng , Qian Ying , Fan Chunlei , Tian Nan
Published: April 2021

Background: Although curcumol has been shown to possess antitumor effects in several cancers, its effects on glioma are largely unknown. Recently, lncRNAs have been reported to play an oncogenic role through epigenetic modifications. Therefore, here, we investigated whether curcumol inhibited glioma progression by reducing FOXD2-AS1-mediated enhancer of zeste homolog 2 (EZH2) activation.Methods: MTT, colony formation, flow cytometry, Transwell, and neurosphere formation assays were used to assess cell proliferation, cell cycle, apoptosis, the percentage of CD133+ cells, the migration and invasion abilities, and the self-renewal ability. qRT-PCR, western blotting, immunofluorescence, and immunohistochemical staining were used to detect mRNA and protein levels. Isobologram analysis and methylation-specific PCR were used to analyze the effects of curcumol on TMZ resistance in glioma cells. DNA pull-down and Chip assays were employed to explore the molecular mechanism underlying the functions of curcumol in glioma cells. Tumorigenicity was determined using a xenograft formation assay. Results: Curcumol inhibited the proliferation, metastasis, self-renewal ability, and TMZ resistance of glioma cells in vitro and in vivo. FOXD2-AS1 was highly expressed in glioma cell lines, and its expression was suppressed by curcumol treatment in a dose- and time-dependent manner. The forced expression of FOXD2-AS1 abrogated the effect of curcumol on glioma cell proliferation, metastasis, self-renewal ability, and TMZ resistance. Moreover, the forced expression of FOXD2-AS1 reversed the inhibitory effect of curcumol on EZH2 activation.Conclusions: We showed for the first time that curcumol is effective in inhibiting malignant biological behaviors and TMZ-resistance of glioma cells by suppressing FOXD2-AS1-mediated EZH2 activation on anti-oncogenes. Our findings offer the possibility of exploiting curcumol as a promising therapeutic agent for glioma treatment and may provide an option for the clinical application of this natural herbal medicine.
Study on the Innovation Process in Precision Agriculture using patent mapping using NPK sensors in the production of fertilizers
Authors: Reis Marcello , Reis Patricia , Martinez Maria Elisa , Lopes Youlia , Guimarães Glendo , De Oliveira Alexandre Maniçoba
Published: April 2021

With the constant population growth, Agroindustry has sought to innovate in its products and processes, with innovation and precision agriculture in the use of NPK fertilizers, and the determination of the concentrations of NPK present in the soil, makes it necessary for the correction of such levels in order to obtain greater soil efficiency and crop productivity, this adopted practice requires the use of sensors both in the bio manager and in the soil for the result to be really valid. There is a need to evaluate the scenario in which the NPK sensors developed to date are inserted in order to contribute to the knowledge in this area of study. One of the ways to carry out such an evaluation is through the information contained in the patent documents, the objective of this article. With the search for these documents, 95 patent documents were selected after reading and analyzing the abstracts, where the presence in both the soil and the soil and in the bio manager, we had 66% of the cases, and China (96%), which is the country that consumes the most fertilizers, as parents that most protects its innovations with emphasis on the Jiangsu region.
Fig. 6. The portion of Mimusops kummel suitable areas covered by protected areas, under current (A) and future projections in 2050 under (B) CNRM-CM5 and (C) HadGEM2-ES model climates with scenario RCP8.5, and (D) CNRM-CM5 and (E) HadGEM2-ES model climates with scenario RCP4.5.
Authors: K.Sinasson Gisèle , Shackleton Charlie M. , Teka Oscar , Sinsin Brice
Published: April 2021

Understanding the niche and
habitat requirements of useful and threatened species, their shifts under climate
change and how well protected areas (PAs) preserve these habitats is relevant
for guiding sustainable management actions. Here we assessed the ecological
factors underlying the distribution of two multipurpose and threatened species, Mimusops andongensis and M. kummel, in Benin, and potential changes in the suitable
habitats covered by PAs, under climate change scenarios. Fifty seven occurrence
points were collected for M. andongensis and 81 for M. kummel.
A Synopsis on COVID-19 and Associated Risk Factors: Optimizing Preventive and Clinical Outcomes through Lifestyle Intervention
Authors: Adelowo Abiodun Bamidele
Published: April 2021

Since its outbreak in late 2019, Coronavirus Disease 2019 (COVID-19) has been ravaging the health system of most countries of the world. Although many preventive and treatment strategies have been proposed and implemented to combat the disease, these efforts seem to be insufficient, and in some cases ineffective. This is evident by the daily rising global incidence and case fatality of the COVID-19 pandemic. A situation if not mitigated early will likely crumble the global economy and tilt the world to an unprecedented global recession. This challenge demands that researchers and clinicians ask more in-depth questions about the novel coronavirus disease. Aside from age that has been confirmed to be linearly associated, what are the other possible socio-demographic and lifestyle-related risk factors that may be associated with COVID-19? What are the possible factors or comorbid conditions that may worsen clinical progression and determine the clinical outcome in confirmed COVID-19 cases? Does the pre-, peri-, or post-morbid lifestyle choices of people have an impact on COVID-19 preventive and treatment efforts? And how can we use the knowledge of the associated risk factors, comorbid conditions, and lifestyle choices of people to improve preventive efforts and clinical management of COVID-19? Answer to these questions may likely serve as an important guide for policymakers and clinicians in their design and implementation of COVID-19 targeted preventive and treatment policies and programs, especially in Low- and Middle-Income Countries (LMICs). The purpose of this article is to critically review available literature and provide evidence-based recommendations.
Determinants of Immunization Coverage and Associated Factors among Children aged under Two-Year-Old in the National Immunization Program of Mewat district, Haryana (2019-2020)
Authors: Kumar Vishesh
Published: April 2021

Background: Vaccination against childhood communicable diseases through Expanded Program on Immunization is one of the most cost-effective public health interventions. Additional 1.5 million child deaths can be prevented if global vaccination coverage is improved. Mewat district has one of India’s lowest immunization rates despite a long-standing Universal Immunization Program and continues to sustain a high prevalence of vaccine-preventable diseases. This study investigates determinants of immunization status among children aged 0-23 months. Methods: A community-based cross-sectional study was conducted from December 2019 to June 2020, among 800 children aged 0-23months, randomly selected in one rural and one urban ward each from all 4 blocks of Mewat. Socio-demographic conditions and vaccine-related data were collected using a semi-structured questionnaire. Immunization was assessed by vaccination card and by mother’s recall where the card was unavailable. Results:Mewat has increased full immunization coverage from 13.1% in 2015-16 to 59.4%. Immunization card was available with 68.5% (292/426) beneficiaries. Dropout rates for Pentavalent1 to Pentavalent3 was 27.5% and 54% for Bacillus Calmette-Guerin to measles. After adjusting for the state of residence, religion, gender, paternal education, health professional presence during birth, place of vaccination and knowledge of mother on due dose were significantly associated with full immunization. Awareness gap and fear of side effects for vaccines were main reasons of vaccine hesitancy. Conclusion: Full immunization coverage in the district is sub optimal and behind the desired coverage goal, mainly due to vaccine hesitancy. Enhancing community knowledge about the benefits of vaccination is recommended.
CONHECIMENTO E ATITUDE NO ATENDIMENTO DE IDOSOS COM DEMÊNCIA ENTRE MÉDICOS E ENFERMEIROS DA ESTRATÉGIA SAÚDE DA FAMÍLIA
Authors: Barbosa Luis Fernando De Lima Nunes , Ferreira Darlene Darlene Glória de Ávila , Corrêa Karina , Silva Junior Manoelito Ferreira , De Sousa Maria da Luz Rosário
Published: April 2021

O objetivo do presente estudo foi avaliar o conhecimento e a atitude no atendimento aos pacientes idosos com demência entre médicos e enfermeiros da Estratégia Saúde da Família (ESF). O estudo foi realizado com médicos e enfermeiros das Unidades da Estratégia Saúde da Família de Piracicaba-SP. Foi aplicado um questionário com o perfil sociodemográfico e profissional, teste Conhecimento da doença de Alzheimer (Alzheimer Disease Knowledge) com três eixos (epidemiológico, diagnóstico e gerenciamento) e sobre atitude no atendimento aos pacientes com demência. A amostra foi composta todos os 26 médicos e 44 enfermeiros da ESF, sendo a maioria de mulheres (n=58), média de idade de 38,4 anos e de tempo de formado de 12,6 anos. Dos participantes da pesquisa, 17 atendem rotineiramente na sua prática clínica idosos demenciados, 46 esporadicamente e 7 não costumam atender estes pacientes. Os acertos sobre doença de Parkinson foram maiores para os médicos (47,8%) em relação aos enfermeiros (39,8%) (p=0,0042) e os maiores erros foram relacionados ao diagnóstico (32,4%). Os profissionais de saúde, na sua grande maioria, também apresentaram atitudes sinceras e animadoras que podem contribuir para o atendimento e gerenciamento dos pacientes e seus cuidadores. O conhecimento entre médicos e enfermeiros foi baixo o que sugere necessidade de uma intervenção educativa nesta área de conhecimento e aplicação. No entanto, as atitudes favorecem positivamente o atendimento aos idosos demenciados e suas famílias.
A CONTRIBUIÇÃO DOS ANIMAIS NO CUIDAR DE ENFERMAGEM: UMA REVISÃO BIBLIOGRÁFICA
Authors: Figueiredo Rogério Carvalho de , Da Silva Rosália Freitas , Teixeira Márcia Maria Coelho , Silva Leidiany Souza , Silva Rafael Souza
Published: April 2021

RESUMO A terapia assistida por animais (TAA) é um método com discernimentos específicos a qual o animal é um componente fundamental no tratamento, e que vêm favorecendo a evolução do estado físico, emocional e melhorar a aparência social  do paciente, com diversos benefícios. Este estudo teve como objetivo evidenciar as contribuições dos animais no processo de cuidar dos profissionais da enfermagem em pacientes hospitalizados. Refere-se a um estudo descritivo, qualitativo, que seguiu os pressupostos da revisão bibliográfica narrativa, orientado a partir da questão: “Qual a contribuição dos animais no processo de cuidar em Enfermagem à pacientes hospitalizados?”. Foram utilizadas produções científicas publicadas no período de 2005 a 2018. A busca das produções ocorreu durante os meses de setembro e outubro de 2018 nas bases de dados BIREME, LILACS, SCIELO, Google Acadêmico e Repositórios de Teses e Dissertações de Universidades Federais. Os estudos mostram inúmeros benefícios com intervenções que utilizam animais no cuidar de enfermagem, tendo como princípio o amor e a amizade que surgem entre o ser humano e os animais. O convívio com esses animais podem trazer benefícios como: facilitar o processo de adaptação à doença e ao ambiente hospitalar, maior e melhor coordenação motora, melhora na função cognitiva, desenvolvimento eficiente e mais rápido do campo visual e do envolvimento com o mundo exterior, além de reduzir a ansiedade e o estresse. A enfermagem, com seu cuidado direto ao paciente, é muito beneficiada pela TAA, pois ela facilita o vínculo com os pacientes e a comunicação entre eles. Palavras-chaves: terapia assistida por animais; animais; cuidado de enfermagem.
TRANSFORMADA INVERSA DE LAPLACE PARA ANÁLISE DE SINAIS DE RESSONÂNCIA MAGNÉTICA NUCLEAR DE BAIXO CAMPO
Authors: Moraes Tiago
Published: April 2021

INVERSE LAPLACE TRANSFORM FOR SIGNAL ANALYSIS OF LOW FIELD NUCLEAR MAGNETIC RESONANCE. The objective of this work is to describe the mathematical procedure denominated ‘Inverse Laplace Transform’ used to process Low Field Nuclear Magnetic Resonance signals of experiments as CPMG, Inversion Recovery and Saturation Recovery. Also, we present a developed script, “ILT Origin script” v.1, in the environment of the software Origin Lab 9 to execute it. The presented ILT is executed with an algorithm of non-negative last square, with Tikhonov regularization and singular values decomposition. The main features of the code were tested using simulated and experimental signals, and in order to validate the results the same sets of data were analyzed using similar ILT softwares. The developed scripts for Origin Lab, Matlab and other languages are available for free for scientific and teaching uses.
Kısmi Gölgelenme Etkilerini Modelleyebilen Bir PV Emülatör Tasarımı
Authors: ÇINAR Said Mahmut , ARSEVEN Burak
Published: April 2021

Güneş ışınımından elektrik enerjisi üretmekte kullanılan güneş (photovoltaic-PV) panellerinin çıkış
karakteristikleri ışınım, sıcaklık, gölgelenme ve panel yüzeyinin temizliği gibi pek çok parametreden
etkilenmektedir. Bu parametrelerden ışınım, sıcaklık ve gölgelenme çevresel şartlara bağlıdır ve PV paneli içeren sistemlerin testi söz konusu olduğunda aynı çevresel şartların tekrar elde edilmesi mümkün olmamaktadır. PV paneli emülatörleri belirli bir zaman dilimini kapsayan ışınım, sıcaklık ve gölgelenme veri setlerini kullanarak o zaman dilimindeki çevresel şartların oluşturulmasını ve böylece PV paneli sistemindeki testlerin aynı çevresel koşullarda tekrar edilmesini sağlayabilir. Bu çalışmada kısmi gölgelenme etkilerini modelleyebilen bir PV paneli emülatörü tasarımı gerçekleştirilmiştir. Söz konusu PV emülatörü, her biri yirmi hücreden oluşan ve atlama diyotları ile köprülenmiş hücre gruplarını temsil eden üç düşüren DC/DC dönüştürücüye, 250 W çıkış gücüne ve 32−bit mikro-denetleyici kontrol kartına sahiptir. Tasarlanan PV emülatörü iki farklı ışınım ve modül sıcaklığı senaryosuyla test edilmiştir. Elde edilen deneysel sonuçlar, MATLAB/Simulink ortamında alınan simülasyon sonuçlarıyla karşılaştırılmıştır. Son olarak istatistiki analizlerle deneysel ve simülasyon sonuçlarının oldukça yüksek oranda örtüştükleri saptanmıştır. Performansı oldukça yüksek çıkan emülatör sayesinde herhangi bir saha, çatı ve cepheye kurulabilecek PV sistemlerinin tekno-ekonomik fizibilite analizi rahatlıkla yapılabilecektir.
Güçlendirme Ankrajlarının Kesme Performansının Mevcut Yığma Duvarlar Üzerinde Belirlenmesi
Authors: ÇELİK Fatih , DOGAN Orhan
Published: April 2021

Türkiye nüfusunun büyük bir kesimi deprem riski yüksek bölgelerde yaşamaktadır. Bu bölgelerde bulunan binaların, yapıldıkları yıllardaki mühendislik hizmetlerindeki eksiklik, kalitesiz malzeme kullanımı ve işçilik hatalar nedeniyle mevcut binaların yaklaşık 2/3’ünün güçlendirilmesi gerektirmektedir. Mevcut bir yığma duvarı yatay yüklere karşı güçlendirmek için duvarın bir ya da iki yüzeyine eklenecek çelik veya betonarme levhaların mevcut duvarla kısmi veya tam bir bağla birlikte hareket edebilmesi için konektörlere ihtiyaç vardır. Mevcut duvarın ve eklenecek güçlendirme elemanının yatay deprem kuvvetlerine karşı rijitlikleri farklı olacağından, aralarında oluşacak kesme ve çekme kuvvetlerine karşı, bu konektörlerin yeterli esneklik, aralık, çap ve derinlikte olması gerekmektedir. Bu çalışmada konektör olarak, esnek ve kolay temin edilebilir olması bakımından betonarme çelik çubuk parçaları tercih edilmiştir. Yığma duvar yüzeyine ankre edilecek bu konektörlerin sayılarını belirleyebilmek için çap ve derinliklerine bağlı kesme performanslarının belirlenmesi büyük önem arz etmektedir. Bu çalışma kapsamında, mevcut bir binanın duvarlarına ankrajlanan farklı çaplarda ve derinliklerde güçlendirme çelik çubuklarının kesme performanslarını belirleyebilmek için özel tasarlanmış, pratik ve kullanışlı çelik levhalı deney düzeneği kullanılmış ve 3 farklı binada toplam 21 adet kesme deneyi yapılmıştır. Ankraj kesme performansı üzerinde ankraj derinliğinin donatı çapına oranla çok fazla etkili olduğu görülmüştür. Ayrıca ankraj çubuğunun çapına ve derinliğine bağlı olarak kesme kuvvetini veren parabolik bir denklem elde edilmiştir.
Inactivation of Some Pathogens Inoculated to Noodle by Syzygium aromaticum (L.) Merr. & L.M.Perry Essential Oil
Authors: ELİUZ Elif , SICAK Yusuf
Published: April 2021

In this study, it was aimed the the efficacy of Syzygium aromaticum essential oil (EO) on inactivation of Eschericha coli (ATCC 25293), Klebsiella pneumoniae (ATCC 10031), Bacillus subtilis (ATCC 6633), and Staphylococcus aureus (ATCC 25925) inoculated to noodle was investigated by dip incubation method. The components of S. aromaticum EO were analyzed by GC-MS and found the main components as eugenol, (Z)-9,17-octadecadienal (25.96%), (-)-caryophyllene (5.29%), and aceteugenol. Broth Microdilution and Agar Well Diffusion Method were used for antibacterial activity of S. aromaticum EO. Minimum Inhibitory Concentrations (MICs) of S. aromaticum were 14.8 mg mL-1 for E. coli, 10.98 mg mL-1 for K. pneumoniae, 9.29 mg mL-1 for B. subtilis, and 9.8 mg mL-1 for S. aureus, while the inhibition zones were between 3 mm and 7.1 mm for the pathogens. In the study, 100 μL of clove oil have 100% inhibition effect on E. coli, K. pneumoniae, and S. aureus attached to the noodle. However, B. subtilis was found to be quite resistant. As a result, the essential oil appears to be effective agains both Gram-negative and Gram-positive bacteria.
Voltage Dependent Barrier Height, Ideality Factor and Surface States in Au/(NiS-PVP)/n-Si (MPS) type Schottky Barrier Diodes
Authors: BUCURGAT Mahmut
Published: April 2021

Metal-Polymer-Semiconductor (MPS) Schottky Barrier Diodes (SBD) were manufactured and their basic electrical parameters were obtained by the measurement of the forward and reverse bias current-voltage (I-V) in the wide bias voltage range (±3V) to determine the voltage dependent effects on Nickel-Sulphur (NiS) doped Poly Vinyl Pyrrolidone (PVP) polymer interlayer. The saturation current (I0), zero-bias barrier height (ΦB0), rectifying rate (RR), ideality factor (n) and the real value of series - shunt resistances (Rs - Rsh) were calculated. The voltage dependent profile of n (V), ΦB(V), and Rs (V) were derived. The forward bias ln I-V plot of the MPS type SBD indicates a good rectifier behaviour and it has two distinctive linear parts with different slopes which correspond to low (0.288 ≤V ≤0.625 V) and moderate (0.672 ≤ V ≤ 0.960 V) bias voltages and then deviates from linearity due to Rs and interlayer at high forward bias voltages. Energy dependent profile of Nss was obtained from the forward bias I-V data by considering voltage dependent barrier height (ΦB) and n. Nss plot represents U-shape behaviour in the forbidden bandgap. The mean value of Nss was found at about 7.0x1012 eV-1 cm-2 and this value is in the acceptable limit for a semiconductor device and such lower values of Nss are the consequences of the passivation effect on the surface states.
Potansiyel Biyolojik Aktif Bazı Asimetrik Feniletil Üre Türevlerinin Sentezi
Authors: AKBABA Yusuf
Published: April 2021

Bu çalışmada, bir dizi potansiyel biyolojik aktif asimetrik üre türevi sentezlenmiştir. Buna göre (R)-(+)-1-feniletilamin (7) 1,1’-karbonildiimidazol ile su içerisinde reaksiyona sokulmuş ve imidazolid ara ürünleri oluşturulmuştur. Daha sonra üzerine fenetilamin (8a) ve sübstitüe fenetilamin türevleri (8b-e) verildi. Sonuç olarak, potansiyel biyolojik aktif yeni asimetrik üreler (R)-1-fenetil-3- (1-feniletil) üre (9a) ve sübstitüe türevleri (9b-e), % 60 - % 71 arasındaki verimlerle elde edildi.
Raman Excitation of Hydrogen Molecules to v = 1 State
Authors: CANDAN İlhan
Published: April 2021

Coherent anti-Stokes Raman scattering (CARS) can reveal a molecule’s vibrational spectrum to a great extent. Instantaneous interaction of Stokes and pump beams stemming from powerful pulsed lasers excites a molecule’s vibrational modes in CARS. In this technique, combining two visible laser beams could create spectra resonances relating to vibrational transitions. In this work, Raman excitation of Hydrogen molecules to v = 1 state is achieved by CARS spectroscopy. CARS measurements are successfully carried out for H2 S-branch and Q-branch transitions using our laser system. This measurement proves the feasibility of CARS experiment which could be employed to excite molecules to a specific rovibrational state. Moreover, experiments conducted for CARS signal with respect to various gas pressures differing between 200 and 600 torr for S-branch transition of H2 molecule.
Hay Production of Smooth Bromegrass (Bromus inermis Leyss.) as Influenced by Various Management Practices in Highlands
Authors: TAN Mustafa , ÇORUH İrfan
Published: April 2021

The effects of sowing time and companion crop on hay yield, weed rate and some hay quality parameters of smooth bromegrass were determined in 2014 and 2015. Smooth bromegrass was sown in spring and summer period with or without wheat as a companion crop. The study was established according to the experimental design of randomized complete blocks in irrigated conditions with three replications. Sowings mixed with companion crop in spring produced higher dry matter yield in the first year and in the second year. Mixed sowing with companion crop decreased the rate of weeds in the first year from 76.7% to 7.8%. Sowing time was not effective on hay quality, but the use of companion crop decreased the crude protein content and increased ADF and NDF ratios in the establishment year.
The Effect of Humic Acid Applications on Growth and Quality Properties of Potato (Solanum tuberosum L. )
Authors: ÇÖL KESKİN Nursel , AKINERDEM Fikret
Published: April 2021

This study was carried out in Konya Soil, Water and Combating Desertification Research Station in 2015 in
order to determine the effect of humic acid applications in different amounts on the development and quality properties of some potato varieties in Konya ecological conditions. Three different potato varieties (Agria, VR808, Brooke) and four different humic acid doses (0, 3, 6, 9 L da-1) were used in this study, which was established in three replications according to "The Randomized Complete Block in a Split Plot Design". In the study, large, medium, small, discarded tuber yields per decare, protein content, specific gravity, chips yield, oil holding capacity of chips, dry matter content, starch content were investigated. It was determined that there was a significant increase in humic acid applications in large, medium, small and discarded tuber yields per decare. Oil holding capacity of chips was between 32.9 % and 46.2 %, starch content was between 11.7 % and 17.3 %, and the differences between humic acid applications were found to be statistically significant for these
properties. In terms of chips yield and protein content, statistical significance was not determined among the applications. Considering all the properties examined, it was determined that increasing humic acid applications positively affected the yield of large, medium and small discarded tubers per decare and significant variations were obtained among some quality properties of the varieties.
Iğdır Ekolojik Şartlarında Bazı Yonca (Medicago sativa L.) Çeşitlerinin Kalite Özelliklerinin Belirlenmesi
Authors: KESKİN Bilal , TEMEL Süleyman , EREN Barış
Published: April 2021

Araştırma, tescil edilmiş 18 çeşit ve 1 yerel genotip olmak üzere toplam 19 çeşidin Iğdır ekolojik şartlarında 2017, 2018 ve 2019 yıllarındaki yem kalite özelliklerinin belirlenmesi amacıyla yürütülmüştür. Çalışma Iğdır Üniversitesi Tarımsal Uygulama ve Araştırma Merkezine ait sulu deneme sahasında tesadüf blokları deneme desenine göre 3 tekerrürlü olarak kurulmuştur. Bu araştırmada Başbağ, Gea, Elçi, Kayseri, May İside, Magna 601, Savaş, Ezzeline, Magnum V, La Bella, Giulia, Plato, La Torre, Prosementi, Queen, Bilensoy 80, Emiliano, Sunter ve Gacer (yerel genotip) yonca çeşitlerinin ham protein oranı (HP), asit çözücülerde çözünemeyen lignin (ADL), nötr çözücülerde çözünemeyen lif (NDF), asit çözücülerde çözünemeyen lif (ADF), kuru madde sindirilebilirliği (KMS), kuru madde tüketimi (KMT), sindirilebilir enerji (SE), metabolik enerji (ME) ve nispi yem değeri (NYD) belirlenmiştir. Üç yıllık ortalamaya göre yonca çeşitlerinin HP oranları %16.9 ile %22.0, ADL oranları %6.88 ile %9.81, NDF oranları %39.4 ile %42.9, ADF oranları %28.1 ile %31.9, KMS oranları %64.1 ile %67.0, KMT oranları %2.82 ile %3.06, SE miktarları 3.01 ile 3.14 Mcal kg-1, ME miktarları 2.47 ile 2.58 Mcal kg-1 ve NYD değerleri 141.2 ile 156.8 arasında değiştiği belirlenmiştir.
Bridgman Tekniği ile Büyütülen Saf ve Bor Katkılı InSe Tek Kristallerinin Morfolojik ve Optik Özelliklerinin Araştırılması
Authors: ERTAP Hüseyin , KARABULUT Mevlüt
Published: April 2021

Bridgman tekniği ile büyütülen saf, % 0.1 ve % 0.5 bor katkılı InSe tek kristallerinin morfolojik ve optik soğurma özellikleri araştırıldı. Saf, % 0.1 ve % 0.5 bor katkılı InSe tek kristallerinin morfolojik ve optik soğurma özellikleri AFM, SEM ve UV-Vis spektrofotometre teknikleri ile araştırıldı. SEM analizleri geniş yüzeyli yüksek kalitede InSe tek kristallerinin stokiyometrik eriyikten büyüdüğünü gösterdi. Optik soğurma spektrumlarının analizinden saf ve % 0.1 bor katkılı InSe tek kristallerine oranla % 0.5 bor katkılı InSe tek kristalinin eksiton pikinin genişlediği görüldü. Ayrıca, bor katkısı sonucu soğurma şiddetinin azaldığı ve soğurma kenarının daha uzun dalga boyuna doğru kaydığı görüldü. Optik soğurma ölçümlerinden, hem saf hem de bor katkılı InSe tek kristallerinin direkt yasak enerji bant aralığına sahip olduğu gözlendi. Ayrıca, saf InSe tek kristalinin yasak enerji bant aralığına oranla bor katkılı InSe tek kristallerinin yasak enerji bant aralıklarının katkı oranına bağlı olarak azaldığı görüldü.
Design, Synthesis and Antimicrobial Activities of New Carbon Nanotubes Derivatives
Authors: YİĞİT Aybek , ALMA Mehmet Hakkı , AKINAY Yüksel , MENGEŞ Nurettin
Published: April 2021

Even though natural products or crops have been more common and popular in the recent, the chemicals without side-effects have been also addressed in various fields of industries due to possibility obtaining the large quantity and more bio-efficacy. In that context, many drugs have been developed for antibacterial activities but the over-uses of those relevant drugs have caused that microorganisms have adapted and evolved resistance against those drugs. Those lead to the researchers to focus on newly synthesized or functionalized molecules. In that context, nanotechnology, especially modified nanocarbon tubes (NCTs), are of the great interest of the various industries. Along with the current study, multi-walled carbon nanotubes (MWCNTs) were functionalized with three steps. Firstly, the carbon nanotube with a carboxylic acid tip on its surface was commercially purchased and then converted into acyl chloride, and later converted into a more reactive group. Then, the nucleophilic amino group such as diethylene triamine is bonded onto the carbon nanotube. Finally, after the carbon nanotube material with amine groups was functionalized with boric acid, carbon nanotube molecules carrying boric acid molecules were synthesized. Following modification and functionalization of MWCNTs, the newly synthesized molecules were characterized using FT-IR, SEM, TEM and XPS. After chemical characterization, the relevant molecules were screened for their anti-bacterial activities in comparison to those of well-known antibiotics. For anti-bacterial assays, molecules were tested against K. pneumoniae, E. coli, P.aeruginosa, S. aureus and B. subtilis. Concerning the findings of the antibacterial assays, concentrations of 40 and 80 μg /mL exhibited a range of activities but in parallel with those of standard antibiotics whereas the lower concentration, viz. 5, 10 and 20 μg / mL did not exhibit any activities. The highest activity was noted for 80 μg / mL, in comparison to those of antibiotics and other concentrations, against B. subtilis, with a 23 mm inhibition zone.
Anjiyotensin Dönüştürücü Enzim İnhibitörlerinin Foton Etkileşim Parametrelerinin İncelenmesi
Authors: TURHAN Mehmet Fatih
Published: April 2021

Bu araştırmada bazı anjiyotensin dönüştürücü enzim (ADE) inhibitörlerinin kütle azaltma katsayıları, lineer azaltma katsayıları, yarı tabaka kalınlıkları, onda bir tabaka kalınlıkları, ortalama serbest yolları, etkin atom numaraları ve etkin elektron yoğunlukları 1 keV≤ E ≤100 GeV enerji aralığındaki farklı enerji için teorik olarak belirlenmiştir. Ayrıca, ADE inhibitörlerinin enerji soğurma yığılma faktörleri ve maruz kalma yığılma faktörleri 0.015 MeV≤E≤15 MeV enerji aralığındaki bazı enerji değerleri için 40 mfp ye kadar farklı penetrasyon derinliklerinde geometrik ilerleme (G-İ) fit katsayıları kullanılarak hesaplanmıştır.
κ-casein polymorphism effect on technological properties of dried milk
Authors: Vafin Ramil , Radaeva Iskra , Kruchinin Alexandr , Illarionova Elena , Bigaeva Alana , Turovskaya Svetlana , Belozerov Georgy , Gilmanov Khamid , Yurova Elena
Published: April 2021

Introduction. Numerous molecular genetic studies have revealed a correlation between the polymorphism of milk protein genes and the technological properties of milk raw materials. DNA analysis, in particular, initiated research into the influence of allelic variants of κ-casein (CSN3) on thermal stability and cheese suitability of milk. This gives relevance to our study that compares the results of genotypic identification of lactating cows by the κ-casein gene, using raw and processed milk samples.

Study objects and methods. Our study used raw and reconstituted milk samples from first-calf cows of the black motley breed with the AA and BB genotypes of the κ-casein gene. The samples were analyzed by standardized and generally accepted chemical engineering methods, as well as by capillary electrophoresis and PCR-RFLP analysis.

Results and discussion. We compared the results of tests on thermal stability and cheese suitability of raw and reconstituted milk samples from cows with the AA and BB genotypes of the κ-casein gene. We tried out an integrated approach to monitoring milk raw materials based on the most relevant technological criteria and correlating the data with the associated CSN3 gene identification parameters. The PCR-RFLP analysis revealed reproducible results for both raw and dried milk samples in relation to the genotypical identification by the A- and B- allelic variants of the CSN3 gene. The tests showed higher thermal stability in the reconstituted milk from the BB genotype cow and better cheese suitability in the AA genotype sample.

Conclusion. We developed a system for evaluating milk raw materials based on the most important technological parameters in combination with their genotypic characteristics. Our research procedure can unify the accumulation of experimental data and contribute to the formation of bioinformatics algorithms. This approach can be used in mathematical modeling of criteria to evaluate the compliance of the technological properties of milk with the recommended indicators.
Detection and attribution of reference evapotranspiration change (1951–2020) in the Upper Yangtze River Basin of China
Authors: Wang Manlin , Zhang Yu , Lu Yan , Gong Xulong , Gao Li
Published: April 2021

Reference evapotranspiration (ET0) indicates atmospheric evaporating capability over a hypothetical reference surface. ET0 is an important hydrological and meteorological variable to reflect climate change. This is particularly true for the Upper Yangtze River Basin (UYRB), which is vulnerable and sensitive to changing environment. This study aims to provide a newer and longer description of ET0 change and the causes at basin and subbasin scales in the UYRB. Based on the observed data from 1951 to 2020, ET0 in the entire UYRB and subbasins is estimated using the Penman–Montieth method with local calibration. The spatial–temporal characteristics in ET0 change are identified from time-series analysis. Our results show that ET0 increases significantly by 3.3 mm/year in the entire UYRB. Stations with significant increases in annual ET0 are concentrated in the central part of the UYRB, where the mean annual ET0 is low. We further propose an improved method to assess the causes of ET0 change. Our results suggest that the relative humidity decrease has the most dominant effect, causing 4.69 mm/year of ET0 increase. Temperature increase tends to cause 1.26 mm/year of ET0 increase. Sunshine duration decrease and wind speed decrease contribute to 1.96 and 0.48 mm/year of ET0 decrease.
Recepcja osiągnięć psychologii i psychiatrii w prawie małżeńskim
Authors: Dzierżon Ginter
Published: April 2021

In the presented lecture the author analyzed the issue of the reception of psychological and psychiatric achievements in the canonical system of marital canon law. On the basis of the teachings of the last Popes and the results of doctrine research, he pointed out that the adoption of the results of psychological and psychiatric research in the canonical system does not have any direct character but should be performed according, to strictly determined methodological principles. This is because any canonist attempting to adopt such achievements ought to adjust them to basic system assumptions of canon legal order. The author of the study demonstrated that such principles were clearly determined in two allocutions to Roman Rota of Pope John Paul II delivered in 1987 and 1988. The speeches of the Pope make it clear that divergence between psychology (or psychiatry) and the canon system as for the judgment of human activities results mainly from different visions of a human being adopted by the representatives of these branches of knowledge. Different anthropological approach has great impact on the assessment of human behavior and also on one’s understanding of marriage. This led the author to the conclusion that in order to unify the judgment about one’s capability to get married, much more effort should be put into developing interdisciplinary anthropology.
Przyczyny i procedury przeniesienia duchownych do stanu świeckiego na podstawie uprawnień Kongregacji ds. Duchowieństwa
Authors: Barszcz Waldemar
Published: April 2021

Il presente studio ha lo scopo di illustrare le tre facoltà speciali concesse dal Sommo Pontefice alla Congregazione per il Clero, al fine di procedere, in via amministrativa, alla riduzione allo stato laicale dei chierici che si trovano in situazione irregolare. Tali facoltà sono gli strumenti di cui possono servirsi tutti gli Ordinari (diocesani e religiosi), nei casi dove appare chiara una violazione della legge da parte del chierico e quando l’interessato non intende chiedere, in via graziosa, la dispensa dagli obblighi che derivano dall’Ordine Sacro. Le facoltà sono state concesse anzitutto le situazioni dove non è possibile, o non è conveniente, procedere per le vie già previste dalla legge. La competente Congregazione ha elaborato gli schemi che illustrano la procedura che ogni Ordinario deve seguire prima di presentare i singoli casi alla Sede Apostolica (cf. allegato). Il contenuto puntualizza innanzitutto le procedure, presentando, con indicazioni pratiche ed esplicative, l’applicazione delle norme particolari, specie a livello locale, prima della presentazione dei casi alla Sede Apostolica.
Разработка методики прогностической оценки устойчивости к профессиональному информационному стрессу летного состава
Authors: Красильников Геннадий Т. , Крачко Эльвира А. , Мальчинский Федор В.
Published: April 2021

Введение. Стрессоустойчивость является профессионально важным качеством в летной профессии, однако рекомендованные нормативными документами методики определения стрессоустойчивости (нервно-психической устойчивости) у абитуриентов военных летных училищ носят бланковый характер и достаточно субъективны. Научная новизна исследования заключается в разработке методики объективной оценки устойчивости к воздействию экспериментального информационного стресса.

Методы. Разработана методика оценки устойчивости испытуемых к воздействию информационного экспериментального стресса, предназначенная для применения в профессиональном психологическом отборе летного состава. В качестве стрессора выступает комплекс стрессогенных стимулов: условия конкурсного экзамена, усложненные арифметические задания, воздействие помех, оказывающих как шумовой, так и дистракторный эффект. Выраженность устойчивости к стрессовой реакции определялась по динамике продуктивности умственной деятельности в процессе тестирования, физиологической «цене» деятельности по частоте сердечных сокращений на разных этапах прохождения экспериментального стрессового обследования, внешним проявлениям поведения (речи, движениям, позе, мимике). Стандартизация показателей рассчитывалась на представительной выборке (n = 3191) с использованием пакета статистических программ «Описательная статистика» из «Microsoft Excel 2007». Авторский сценарий методики встроен в программное обеспечение многофункционального психофизиологического комплекса «Реакор».

Результаты и их обсуждение. Проведено исследование по применению методики на выборке 1135 кандидатов на поступление в высшее военное летное училище, мужского пола, возраст 18–27 лет. Получены данные о наличии значимой корреляционной связи оценки стрессоустойчивости по психометрическим показателям стрессовых проявлений у испытуемых (психологический, физиологический, поведенческий критерии) с успешностью их летного обучения по данным экспертных оценок за тренажерную подготовку и летную практику. Полученные данные исследования свидетельствуют о том, что разработанная методика оценки устойчивости к экспериментальному информационному стрессу является чувствительным тестом на выявление стрессоустойчивости и ее можно рекомендовать для использования в профессиональном психологическом отборе в летные профессии.
Differentiation Between Osteoporotic and Neoplastic Vertebral Fractures: State of The Art and Future Perspectives
Authors: Musa Aguiar Paula , Zarantonello Paola , Aparisi Gómez Maria Pilar
Published: April 2021

:

Vertebral fractures are a common condition occurring in the context of osteoporosis and malignancy. These entities affect a group of patients in the same age range; clinical features may be indistinct and symptoms non-existing, and thus present challenges to diagnosis. In this article, we review the use and accuracy of different imaging modalities available to characterize vertebral fracture etiology, from well-established classical techniques to the role of new and advanced imaging techniques and the prospective use of artificial intelligence. We also address the role of imaging in treatment. In the context of osteoporosis, the importance of opportunistic diagnosis is highlighted. In the near future, the use of automated computer-aided diagnostic algorithms applied to different imaging techniques may be really useful to aid in diagnosis.
The Malaysian Women's Experience of Care and Management of Postnatal Depression
Authors: Arifin Siti R.B.M. , Cheyne Helen , Maxwell Margaret , Yousuf Abdilahi
Published: April 2021

Objectives:

Early detection and intervention for Maternal Postnatal Depression (PND) are imperative to prevent devastating consequences for mothers, babies, and families. However, there are no guidelines that explicitly focus on the management of PND in Malaysia. Consequently, it is unclear whether women with PND are receiving proper care and treatment. Therefore, this study aimed to explore Malaysian Women's experience in managing PND symptoms.

Methods:

A qualitative study was conducted among 33 women attending Maternal and Child Health (MCH) clinics in Kuala Lumpur. Data were obtained through a face-to-face semi-structured interview and analysed using framework analysis.

Results:

The women considered PND as a personal and temporary issue. Therefore, professional care was deemed unnecessary for them. Additionally, all Malay women considered religious approach as their primary coping strategy for PND. However, this was not the case for most Indian and Chinese women.

Conclusion:

The findings of this study indicated that women did not acknowledge the roles of Healthcare Practitioners (HCPs) in alleviating their emotional distress.Also, they perceived PND as a personal problem and less serious emotional condition. It is due to this perception that the women adopted self-help care as their primary coping strategy for PND. However, the coping strategy varied between different cultures. These findings underscore the importance of HCPs’ proactive action to detect and alleviate PND symptoms as their attitude towards PND may influence Women's help-seeking behaviour.
Mechanistic Study on Thymoquinone Conjugated ZnO Nanoparticles Mediated
Cytotoxicity and Anticancer Activity in Triple-Negative Breast Cancer Cells
Authors: Banupriya Sampath K. , Kavithaa Krishnamoorthy , Poornima Arumugam , Sumathi Sundaravadivelu
Published: April 2021

Background:

In the current era, the development of molecular techniques involves nano techniques,
and the synthesis of nanoparticles is considered the preferred field in nanotechnology.

Objective:

The aim of the present work is to analyze the anticancer activity of the thymoquinone conjugated ZnO
nanoparticles and understand its mechanism of action in triple-negative breast cancer cell lines MDA-MB-231.

Methods:

Zinc Oxide (ZnO) nanoparticles have extensive applications, and it was synthesized using a chemical
precipitation method. Thymoquinone (TQ) is the major bioactive component of the seeds of Nigella sativa.
Synthesized nanoparticles were characterized using various spectroscopic techniques. Thymoquinone-coated
nanoparticles were checked for their efficiency. The cytotoxicity of ZnO, TQ, and TQ conjugated ZnO
nanoparticles against MDA-MB-231. Colony-forming and cell migration assays were performed to measure the
proliferative competence of the breast cancer cells on exposure to nanoparticles. The mechanism of apoptosis
was probed by assessing MMP, interplay between ER stress and ROS.

Results:

The results of the characterization techniques confirmed that the particles synthesized were ZnO and
TQ-ZnO nanoparticles. pH dependent release of the compound was observed. The anti-proliferative effect that
impairs the formation of the colony was found to be enhanced in cells exposed to combined treatment with the
nanoconjugate.

Conclusion:

Hence, the TQ conjugated ZnO nanoparticles can act as an efficient carrier for drug delivery at the
target site in TNBC cells.
A Research on HMM based Speech Recognition in Spoken English
Authors: Wang Na , Zhang Xiaohong , Sharma Ashutosh
Published: April 2021

Background:

The computer assisted speech recognition system enabling voice recognition
for understanding the spoken words using sound digitization is extensively being used in the
field of education, scientific research, industry, etc.

Objective:

This article unveils the technological perspective of automated speech recognition system
in order to realize the spoken English speech recognition system based on MATLAB.

Methods:

A speech recognition technology has been designed and implemented in this work which
can collect the speech signals of the spoken English learning system and then filter those speech
signals. This paper mainly adopts the preprocessing module for the processing of the raw speech
data collected utilizing the MATLAB commands. The method of feature extraction is based on
HMM model, codebook generation and template training.

Results:

The research results show that the recognition accuracy of 98% is achieved by the spoken
English speech recognition system studied in this paper. It can be seen that the spoken English
speech recognition system based on MATLAB has high recognition accuracy and fast speed.

Conclusion:

This work addresses the current research issued needed to be tackled in the speech
recognition field. This approach is able to provide the technical support and interface for the spoken
English learning system.