bluuebunny/crossref_metadata_2025 huggingface dataset:
Allylation of isatin-derived N-Boc-hydrazones followed by Pd-catalyzed carboamination reaction: an entry to 3-spiro-pyrazolidyl-oxindoles
Authors: Gazzotti Stefano , Manenti Marco , Lo Presti Leonardo , Silvani Alessandra
Published: November 2019

The indium-mediated allylation of novel 3-(2-Boc-hydrazono)indolin-2-one derivatives, followed by a palladium-catalysed carboamination reaction, is described to afford unprecedented spirocyclic oxindoles in good yields.
Platinum–(phosphinito–phosphinous acid) complexes as bi-talented catalysts for oxidative fragmentation of piperidinols: an entry to primary amines
Authors: Membrat Romain , Vasseur Alexandre , Moraleda Delphine , Michaud-Chevallier Sabine , Martinez Alexandre , Giordano Laurent , Nuel Didier
Published: November 2019

Platinum–(phosphinito–phosphinous acid) complex catalyzes the oxidative fragmentation of hindered piperidinols according to a hydrogen transfer induced methodology.
Diminished viability of human ovarian cancer cells by antigen-specific delivery of carbon monoxide with a family of photoactivatable antibody-photoCORM conjugates
Authors: Kawahara Brian , Gao Lucy , Cohn Whitaker , Whitelegge Julian P. , Sen Suvajit , Janzen Carla , Mascharak Pradip K.
Published: November 2019

Antibodies conjugated to a photoactive transition metal carbonyl complex afford antigen-directed delivery of cytotoxic carbon monoxide to ovarian cancer cells.
IMPRESSION – prediction of NMR parameters for 3-dimensional chemical structures using machine learning with near quantum chemical accuracy
Authors: Gerrard Will , Bratholm Lars A. , Packer Martin J. , Mulholland Adrian J. , Glowacki David R. , Butts Craig P.
Published: November 2019

The IMPRESSION machine learning system can predict NMR parameters for 3D structures with similar results to DFT but in seconds rather than hours.
In situ transfer of CH3NH3PbI3 single crystals in mesoporous scaffolds for efficient perovskite solar cells
Authors: Guan Yanjun , Xu Mi , Zhang Wenhao , Li Da , Hou Xiaomeng , Hong Li , Wang Qifei , Zhang Zhihui , Mei Anyi , Chen Min , Zhou Yuanyuan , Padture Nitin P. , Hu Yue , Rong Yaoguang , Han Hongwei
Published: November 2019

An in situ crystal transfer method is developed for depositing the perovskite absorber in a triple-mesoscopic scaffold, and fabricating printable perovskite solar cells with enhanced performance.
Sub-nanometer Pt cluster decoration enhances the oxygen reduction reaction performances of NiOx supported Pd nano-islands
Authors: Bhalothia Dinesh , Dai Sheng , Wang Sheng-Po , Yan Che , Huang Tzu-Hsi , Chen Po-Chun , Hiraoka Nozomu , Wang Kuan-Wen , Chen Tsan-Yao
Published: November 2019

With suitable Pt4+ loading for galvanic replacement, Pt clusters will fill in the defect sites on Ni@Pd–Pt (step 1 and step 2). In this event, the overlap between O2 splitting and hydration kinetics optimize the ORR activity of a Pt cluster decorated Ni@Pd NC.
Optimization of anodic porous transport electrodes for proton exchange membrane water electrolyzers
Authors: Bühler Melanie , Hegge Friedemann , Holzapfel Peter , Bierling Markus , Suermann Michel , Vierrath Severin , Thiele Simon
Published: November 2019

In this study we optimize anodic porous transport electrodes (PTEs) for proton exchange membrane water electrolysis (PEMWE) in terms of the titanium substrate, IrO2 catalyst loading and Nafion content.
Simultaneous filter tuning and calibration of the camera and inertial measurement unit camera for a vision inertial navigation system
Authors: Arbabmir Mohammadvali , Ebrahimi Masoud
Published: November 2019

In this study, a novel approach based on multi‐objective genetic algorithm (MO‐GA) is used for simultaneous tuning the unscented Kalman Filter (UKF) parameters and camera and inertial measurement unit camera calibration in a vision inertial navigation system (VINS). This system consists of visual odometry and inertial navigation system (INS) which integrates with a UKF. In order to obtain simultaneous tuning and calibration of the parameters and variables, the MO‐GA minimises the root mean square error of the position and velocity of the vehicle on a selected trajectory of the benchmark data set. Then, the tuned parameters and calibrated variables are placed in the VINS and an adjusted VINS (AVINS) is obtained. For investigating the AVINS, the mentioned system is compared with INS only, VINS based on calibration data of the benchmark data set, and GPS/INS as Real Data on the identical trajectory. Furthermore, in order to evaluate the results of the proposed approach, the AVINS is examined in the second trajectory. The results indicate the proper performance of the presented approach in the simultaneous tuning the filter parameters and calibrating the variables of sensors that are used in the uncalibrated VINS.
Balancing and blade-shaping of a single-blade impeller
Authors: Kurilla Matej , Knížat Branislav , Olšiak Róbert , Slovák Pavol , Hyriak Maroš
Published: November 2019

Single-blade centrifugal pumps with a screw-shaped blade are widely used to pump slurry water containing solids and fibrous matters. These hydraulic machines should be frequently used, because of their suitable hydraulic and mechanical properties, in many industrial areas. There cannot be applied a conventional method to design a single-blade impeller, due to its lack of symmetry. The designing of an impeller, which enables fulfilled main requests such as good hydraulic, mechanical properties and the ball passage diameter as well as the influence of the blade outlet angle on hydraulic parameters is described in this academic paper.
Pseudarthrosen im Mund-Kiefer-Gesichts-Bereich
Authors: Neff Andreas , Jung Jonas
Published: November 2019

Auch wenn sie in Standardsituationen heute selten sind, stellen Pseudarthrosen eine relevante Komplikation dar. Insbesondere nach aufwendigen Kieferrekonstruktionen mittels z. B. Fibula- und Beckenkammtransplantaten sind Komplikationen mit hohen Belastungen für die betroffenen Patienten und die erbringende chirurgische Disziplin verbunden. Dieser Beitrag zeigt, wo und warum Pseudarthrosen in der MKG-Chirurgie heute eine Rolle spielen und welche Therapieoptionen bestehen.
Pseudarthrosen nach Eingriffen am Fuß
Authors: Evers Julia , Ochman Sabine , Milstrey Alexander , Raschke Michael J.
Published: November 2019

Pseudarthrosen können mit Schmerzen und Einschränkungen der Lebensqualität einher gehen. Das Risiko ihr Entstehung kann patientenassoziiert sein und durch Nebenerkrankungen wie Diabetes mellitus, pAVK, Nikotin- oder Alkoholabusus oder fehlende Compliance bedingt sein. Aber auch operationstechnische Komplikationen wie postoperative Infektionen, instabile Osteosynthesen, fehlendes Alignment oder insuffiziente Knochenpräparation bei Arthrodesen sind Faktoren, die zu Pseudarthrosen führen können.

Bei instabilen Osteosynthesen, Infektionen oder Knochendefekten sind Revisionseingriffe häufig unvermeidbar. Aber auch im Verlauf kann eine Pseudarthrose persistieren.

Mechanische Knochenstimulation mit LIPUS oder fhESWT können eine Konsolidierung erzielen ohne die durch einen operativen Eingriff möglichen Risiken in Kauf nehmen zu müssen. Biologische Knochenstimulation mit osteoinduktiven Effekten werden im Bereich der Fußchirurgie verwendet, haben hier jedoch keine Zulassung.

Bei Vorliegen einer Pseudarthrose des Fusses ist die Stabilität des selbigen häufig nicht eingeschränkt wie es bei den langen Röhrenknochen häufig der Fall ist. In straffen Pseudarthrosen ohne entsprechende Symptome ist der Revisionseingriff nicht indiziert und eine orthopädieschuhtechnische Versorgung kann ausreichend sein.
Gefäßzugänge für die Hämodialyse
Authors: Hollenbeck Markus , Schlieps Karsten , Spindler Beate , Kellersmann Richard , Natterer Adalbert , Franzke Udo , Lotz Heide , Reiher Carmen , Rüssmann Despina , Schaller Mathias , von Gersdorff Gero , Pommer Wolfgang
Published: November 2019

Die Planung eines individuell optimalen Gefäßzuganges für die Hämodialyse beginnt frühzeitig vor Beginn der Nierenersatztherapie. Im Vordergrund steht die Chancenwahrung für ein – ggf. mehrschrittiges – Shuntkonzept, das Langlebigkeit mit dem individuellen Patientennutzen verknüpft. Die enge Abstimmung zwischen Shuntchirurgen und Nephrologen ist hierfür – optimalerweise in zertifizierten Shuntzentren – wesentliche Grundlage. Wir schlagen die Verbesserung der Versorgung durch die Etablierung eines Shuntteams aus Ärzten und Pflegekräften im Zentrum zur Verbesserung des Shuntmanagements durch Schulung und Nutzung neuer Techniken, wie die ultraschallgesteuerte Shuntpunktion und -überwachung (Survaillance), vor. Die Verbesserung der Schnittstelle zwischen Klinik und Praxis und die Etablierung eines Shuntregisters sind weitere Maßnahmen zur Optimierung der Gefäßzugangspraxis in den Nierenzentren. Die Motivation der Mitarbeiter für dieses Konzept ist Führungsaufgabe.
Buch des fnb e. V.
Authors: Wiegard-Szramek Ina
Published: November 2019

Eine der Grundlagen eines funktionierenden Qualitätsmanagementsystems (QM-System) ist der PDCA-Zyklus. Der amerikanische Qualitätsexperte W. Edwards Deming entwickelte in den 1950er-Jahren die Methode „Plan – Do – Check – Act“ als Mittel zur ständigen Verbesserung. In Deutschland wird manchmal durch die Übersetzung auch vom PTCA-Zyklus gesprochen, die Anfangsbuchstaben stehen dabei für Planen, Tun, Checken und Agieren. Die Forderung nach einem Verbesserungsprozess hat die Kollegen des fnb e. V. bewogen, 12 Jahre nach der ersten Auflage des QM-Buches in einer neu gebildeten Arbeitsgruppe unter der Leitung von Udo Franzke das QM-Buch zu überarbeiten, zu aktualisieren und neueste Entwicklungen zu berücksichtigen.
Ernährungszustand bei Dialysepatienten
Authors: Radermacher Jörg
Published: November 2019

Die Erkennung und Behandlung der Mangelernährung gehört zum klinischen Standard, wie es sich auch an einer verbesserten Ernährungssituation von Dialysepatienten in rezenten Untersuchungen widerspiegelt. Noch relativ neu ist der etwas unhandliche Begriff „chronic disease related malnutrition“ (C-DRM), der den immer noch gebräuchlicheren Begriff des „protein-energy wasting“ (PEW) ablösen sollte, da er die bei Dialysepatienten auch zur Mangelernährung beitragenden Ursachen besser widerspiegelt. In diesem Artikel wird gezeigt, wie eine C-DRM diagnostiziert werden kann. Es wird auf die wesentlichen Stellparameter für eine gute Ernährung beim Dialysepatienten eingegangen. Neben dem allgemeinen Kalorienbedarf findet dabei als Makronährstoff ausschließlich das Eiweiß (und das darin immer auch vorhandene Phosphat) Erwähnung. An Mineralien wird außerdem auf Natrium und Kalium eingegangen. Beim Vitaminbedarf werden nicht nur die wasserlöslichen – und damit während einer Dialyse herausgewaschenen – Vitamine behandelt, sondern auch die fettlöslichen. Auch an Vitamin D und K mangelt es nämlich häufig. Abschließend wird auf die therapeutischen Möglichkeiten wie die Diätberatung bzgl. einer verbesserten natürlichen Kost, Nahrungsergänzungsmittel, enterale Ernährung via perkutane endoskopische Gastrostomie (PEG) und den Nutzen der parenteralen Ernährung eingegangen.
Comparability in Cross-National Health Research Using Insurance
Claims Data: The Cases of Germany and The Netherlands
Authors: Hrzic Rok , Clemens Timo , Westra Daan , Brand Helmut
Published: November 2019

Objective Comparison is a key method in learning about what works in
health and healthcare. We discuss the importance of comparability in
cross-national health research using health insurance claims data, develop a
framework to systematically asses these threats and apply it to the German
(DaTraV) and Dutch (Vektis) national-level insurance claims datasets.

Methods We propose a framework of threats to the comparability of health
insurance claims databases, which includes three domains: (1) representation of
populations compared, (2) data sources and data processing and (3) database
contents and availability for research purposes. We apply the framework to
analyze the comparability of DaTraV and Vektis databases using publicly
available information (organization’s websites, scientific publications)
and our experiences from an interregional project on rare diseases (EMRaDi).

Results Both databases were created for the same purpose (morbidity-based
risk adjustment) and use the same underlying sources of data. Differences in
population representation and uncertainty about data processing procedures
represent potential sources of incomparability. Access for research purposes is
feasible in both databases but may be subject to long processing time.

Conclusions We find important threats to the comparability of the Dutch
and German national insurance claims databases and by extension to validity of
any comparative health studies that rely on them. Standard adjustment
techniques, making more information available about data collection and
processing procedures and adding more diagnosis-related descriptors offer ways
to overcome the identified threats to comparability.
Hip Arthroplasty with Increased Expectancy
Authors: Thiele Kathi , Hube Robert
Published: November 2019

The patientʼs demands and expectations after total hip arthroplasty have increased significantly. In particular, the athletic function is the focus of the patientʼs interest, whereby not the basic sports ability is inquired, but also the achievable sports level. The benefits of increased activity with a reduction in cardiovascular mortality and the minimization of osteoporosis risk are contrasted by amplified wear followed by prosthesis loosening. Activities are categorized in low-, intermediate- and high-impact kind of sport. Patient-based influencing factors such as physical condition and expertise in his sport, as well as the self-reference of the surgeon to the desired sport influence the recommendation and advice of the patient. Innovations in prosthesis design and materials technology allow meeting patientʼs expectations and aiming to improve the return to sport. After total hip arthroplasty, the majority of preoperatively active patients return to athletic
activity, although there is a tendency to shift from “high-impact” to “low-impact” sports. The currently recommended sports include swimming, cycling, Nordic walking, sailing, golf, hiking, dancing and cross-country skiing. A limited recommendation exists for tennis (single), alpine skiing, mountain hiking and sportive running. Not recommended are marathon, football, handball, volleyball, basketball, martial arts, high jump, water skiing and rock climbing. The recommendations are based primarily on expert opinions and are in a progressive extension including “high-impact” sports.
Pharmacokinetic and Tolerability Comparison of Sustained and
Immediate Release Oral Formulations of Nifedipine Tablet Formulations: A
Single-Dose, Randomized, Open-Label, Two-Period, Two-Way Crossover Study in
Healthy, Fasting Egyptian Male Volunteers
Authors: El-Masry Soha Mahmoud , El-Khodary Noha Mahmoud
Published: November 2019

Nifedipine is one of calcium channel blockers that commonly used clinically
to treat hypertension and angina in Egyptian patients. A sustained-release
(SR) formulation of nifedipine is available in the Egyptian community and
administered twice daily. This study aimed to to compare the
pharmacokinetics and safety profiles of a 20 mg SR and IR (immediate
release) formulation of nifedipine after single-dose administration in
healthy Egyptian subjects. Randomized, crossed open-label two- way clinical
trial, in 16 healthy adult volunteers, of 24.75±5.20 years, with BMI
23.26±1.756 were assessed. Blood samples were collected at
predefined times for 48 h and analyzed for Nifedipine plasma
concentrations using validated reversed phase liquid chromatography method
with ultraviolet detection. Pharmacokinetics was determined using non-
compartmental model pharmacokinetics and analyzed using one-way ANOVA
(P≤0.05). Following a single oral administration, SR formulation had
a lower Cmax, compared to IR formulation (54.46±17.75 ,
107.45±29.85 ng/mL, respectively), and
Tmax was significantly longer (2.97 vs. 1.13 h) for
the SR and IR formulation, respectively. There was no significant difference
between the SR and the IR formulations for AUC0–last and
AUC0-∞ (326.7±98.28 vs.
309.27±105.53 ng·h·mL−1
and 380.9 ± 105.24 vs.
334.36±108.1 ng·h·mL−1,
respectively). SR formulation of nifedipine showed similar pharmacokinetics
to the IR Formulation (F%=1.049), but it additionally allows
a less frequent administration. Therefore, The nifedipine SR and IR
formulations were well tolerated and displayed comparable safety
profiles.
Clinical Outcome of Dorsal Cervical C1–C2 Fusion Using C1 Lateral Mass Screws, C2 Lamina Screws, and Interarcual Bone Graft Technique
Authors: Baschera Dominik , Tosic Lazar , Oberle Joachim , Golubovic Jagos , Alfieri Alex
Published: November 2019

Aims To evaluate the clinical and radiologic results of patients treated with dorsal cervical C1–C2 fusion using C1 lateral mass screws, C2 lamina screws, and interarcual bone graft.

Methods We retrospectively analyzed the clinical and radiologic results of eight patients treated from 2011 to 2016. Neck pain, neurologic deficits, use of analgesics, vertebral artery injury, C2 root injury, radiologic fusion rate, malposition of screws, and implant failure were examined on day 3 and at 3 and 12 months postoperatively.

Results One patient required revision surgery for a right-sided medial cutout of a lamina screw. None of the patients had vascular or neurologic complications. All patients were pain free and had ceased all analgesic therapy at the first follow-up examination. At the 1-year follow-up there were no complaints of neck pain, no radiologic signs of implant failure were found, and a bony union between C1 and C2 was present in all patients.

Conclusion Dorsal cervical C1–C2 fusion using C1 lateral mass screws, C2 lamina screws, and interarcual bone graft are less common techniques, although they can be used safely and demonstrated excellent clinical results with regard to pain relief and a high fusion rate. The technique is an ideal alternative when other techniques are not safe for anatomical reasons.
Outcomes of Cases of Prenatally-Diagnosed Congenital Pulmonary Airway Malformation
Authors: Beksac Mehmet Sinan , Fadiloglu Erdem , Tanacan Atakan , Unal Canan , Tepe Neslihan Bayramoglu , Aydın Emine , Orgul Gokcen , Yurdakok Murat
Published: November 2019

Objective To evaluate the outcomes of cases of prenatally-diagnosed congenital pulmonary airway malformation (CPAM).

Methods We retrospectively evaluated cases of prenatally-diagnosed CPAM between 2004 and 2018. Ultrasonographic features such as visualization of a fetal lung mass and heterogeneous pulmonary parenchyma were used for CPAM diagnosis. Prenatal and postnatal findings were compared in terms of accuracy regarding the CPAM diagnosis.

Results The sample consisted of 27 cases. There were four cases in which the patients opted for the termination of pregnancy due to the severity of the lesion. A total of 23 neonates were delivered, and CPAM was confirmed in 15 cases. The median gestational age at delivery was 37 weeks (28–40 weeks) and the mean birth weight was 2,776 g. There were two neonatal deaths, one due to pneumothorax, and the other due to hypoplastic left heart syndrome (HLHS). A total of five patients with respiratory problems were operated in the postpartum period. There were eight misdiagnosis: bronchopulmonary sequestration (five cases), congenital lobar emphysema (two cases), and congenital diaphragm hernia (one case).

Conclusion A precise postnatal diagnosis is very important to organize the proper management of the pregnancies with fetuses with CPAM. The positive predictive value of the prenatal diagnosis of CPAM via ultrasonography is of 70.3%. The differential diagnosis of CPAM may be prolonged to the postpartum period in some cases.
Accessory Spleen in Human Fetuses: A Cadaveric Study
Authors: Thomas Sonali , Sinha Devendra Nath , Singh Arvind Kumar , Deopa Deepa , Niranjan Richa
Published: November 2019

Background The aim of the study was to assess the morphological and histological features of accessory spleen in formalin-preserved human fetuses.

Methods The study was conducted on spleen of 40 human fetuses of varied gestational ages without any congenital anomalies with due clearance from the ethical committee. The existence of accessory spleen was investigated during dissection. These were then dissected, weighed, and stained by hematoxylin and eosin as well as Masson’s trichrome method and observed under compound light microscope.

Results In 5 (12.5%) cases, the accessory spleen was revealed in fetuses aged between 29th and 40th gestational weeks. These were located near the splenic hilum. On histological examination, the tissue of accessory spleen revealed a well-defined capsule. White pulp was less differentiated as compared with red pulp area.

Conclusion The accessory spleen is often misdiagnosed by the clinicians for neoplastic growth or lymph node enlargement; therefore, its awareness is important.
Use of an EHR-Integrated Point-of-Care Mobile Medical Photography Application in a Pediatric Emergency Department
Authors: Castillo Richmond M. , Kim Grace Y. , Wyatt Kirk D. , Lohse Christine M. , Hellmich Thomas R.
Published: November 2019

Background Mobile applications allow health care providers to capture point-of-care medical photographs and transfer them to the electronic health record (EHR). It is unclear how providers use these photographs or how they affect clinical care.

Objectives We aimed to understand the content, purpose, and outcomes of point-of-care medical photography performed in the pediatric emergency department (ED) at large academic medical center.

Methods A retrospective chart review was conducted of patients <21 years of age who were seen in the ED and photographed between March 29, 2015 and July 1, 2017 using a secure smartphone application integrated with the EHR. Inter-rater agreement and reliability between the two reviewers was assessed for the first 50 charts, and any discrepancies in interpretation were resolved before proceeding with the remaining data abstraction. The documented rationale for photography, content of photographs, and outcomes were recorded.

Results We identified 619 clinical encounters involving photographs of 605 patients who were eligible for inclusion. Skin was photographed in 499 (81%). The most common finding was rash (N = 177; 29%). Photos were of acceptable quality, with 569 (94%) achieving a score between 4 and 5 out of 5. The primary use of photography was documentation (N = 334; 54%), though teleconsultation was noted in 38 (6%). Nearly one-third (N = 187; 30%) of patients were seen in the ED or outpatient clinic for any reason within 2 weeks, and in 25 (13%), clinical notes explicitly referenced the initial photograph(s). In 53 (9%) cases, patients were photographed at a clinical visit in the subsequent 2 weeks, suggesting that photography was used to track changes over time.

Conclusion Documentation of findings using mobile point-of-care photography allows for high-fidelity documentation and facilitates continuity of care.
Artroplastía Total de Rodilla con Asistencia de Brazo-Robótico: Resultados Clínicos Postoperatorios Tempranos
Authors: Figueroa David , Guiloff Rodrigo , Naranjo Marcela , Figueroa María Loreto , Vaisman Alex , Stierling Carlos , Calvo Rafael
Published: November 2019

Objetivo Describir los resultados clínicos postoperatorios tempranos de la primera serie de pacientes operados de artroplastía total de rodilla (ATR) con asistencia de brazo-robótico en Latinoamérica.

Materiales y Métodos Estudio prospectivo de 52 pacientes (53 rodillas) con gonartoris tricompartimental sintomática operados de ATR primaria con asistencia de brazo-robótico (RIO-MAKO) de manera consecutiva, con seguimiento a 2 meses postoperados. No se excluyeron pacientes. Se utilizó el mismo protocolo anestésico y de rehabilitación. Se realizó revisión de fichas clínicas para recolectar los siguientes resultados: tiempo de isquemia quirúrgica, estadía hospitalaria, tiempo a marcha, dolor postoperatorio diario [Escala visual análoga (EVA)], uso de opioides, rangos de movilidad articular (ROM), pérdida sanguínea, complicaciones y eje mecánico postoperatorio.

Resultados Tiempos de Isquemia: 82 minutos (60–120). Estadía Hospitalaria: 4 días (2–12). Dolor postoperatorio: EVA el mismo día operatorio de 0 (0–10) y previa al alta de 0 (rango 0–4), con 0,3 purgas (0–6,5) de opioides por paciente. Tiempo a marcha (día logrado): 1 día (1–3), cuarenta y cinco pacientes (84,9%) iniciaron la marcha el primer día postoperatorio. ROM (Extensión-Flexión): Aumento progresivo durante el seguimiento. En el control ambulatorio de los dos primeros meses [23 días (13–50)], veintiún pacientes (40%) alcanzaron un ROM mayor o igual a 0–90° y once (20%) presentaron un ROM funcional máximo (0–120°). Pérdida sanguínea: Siete pacientes (13,2%) requirieron transfusión. Complicaciones: un paciente (1,89%) presentó una dehiscencia del cierre de la artrotomía. No hubo otras complicaciones. Eje mecánico postoperatorio: 179,1° (178,2–180).

Discusión Los resultados concuerdan con la evidencia descrita en otras regiones, sugiriendo que la asistencia de brazo-robótico permite resultados postquirúrgicos reproducibles.

Conclusión Los resultados clínicos postoperatorios tempranos de esta serie de pacientes operados de ATR con asistencia de brazo-robótico, muestran una baja percepción del dolor, con bajo consumo de opioides, una rápida recuperación funcional de la marcha y ROM, y excelentes resultados desde el punto de vista del eje mecánico postoperatorio.

Nivel de Evidencia IV.
Rapid evaluation of immobilized immunoglobulins using automated mass-segmented ToF-SIMS
Authors: Madiona Robert M. T. , Welch Nicholas G. , Muir Benjamin W. , Winkler David A. , Pigram Paul J.
Published: November 2019

Surface interactions largely control how biomaterials interact with biology and how many other types of materials function in industrial applications. ToF-SIMS analysis is extremely useful for interrogating the surfaces of complex materials and shows great promise in analyzing biological samples. Previously, the authors demonstrated that segmentation (between 1 and 0.005 m/z mass bins) of the mass spectral axis can be used to differentiate between polymeric materials with both very similar and dissimilar molecular compositions. Here, the same approach is applied for the analysis of proteins on surfaces, focusing on the effect of binding and orientation of an antibody on the resulting ToF-SIMS spectrum. Due to the complex nature of the samples that contain combinations of only 20 amino acids differing in sequence, it is enormously challenging and prohibitively time-consuming to distinguish the minute variances presented in each dataset through manual analysis alone. Herein, the authors describe how to apply the newly developed rapid data analysis workflow to previously published ToF-SIMS data for complex biological materials, immobilized antibodies. This automated method reduced the analysis time by two orders of magnitudes while enhancing data quality and allows the removal of any user bias. The authors used mass segmentation at 0.005 m/z over a 1–300 mass range to generate 60 000 variables. In contrast to the previous manual binning approach, this method captures the entire mass range of the spectrum resulting in an information-rich dataset rather than specifically selected mass spectral peaks. This work constitutes an additional proof of concept that rapid and automated data analyses involving mass-segmented ToF-SIMS spectra can efficiently and robustly analyze a broader range of complex materials, ranging from generic polymers to complicated biological samples. This automated analysis method is also ideally positioned to provide data to train machine learning models of surface-property relationships that can greatly enhance the understanding of how the surface interacts with biology and provides more accurate and robust quantitative predictions of the biological properties of new materials.
Synergy effect of alpha particles by using natural boron in proton therapy: Computational verification
Authors: Kim Moo-Sub , Wai-Ming Law Martin , Djeng Shih-Kien , Shin Han-Back , Choi Min-Geon , Kim Yong-Jin , Choe Bo-Young , Suh Tae Suk , Yoon Do-Kun
Published: November 2019

The use of boron (11B) is recently being investigated to be applied in proton therapy as a proton boron fusion dose enhancement agent. Alpha particles are emitted from the p + 11B → 3α fusion (PBF) reaction analogous to the 10B(n,7Li)α capture (BNC) reaction. If a natural boron content (80% 11B and 20% 10B) is used in proton therapy, the contaminated neutrons, induced by the proton beam traversing a water medium, will react with 10B and the primary protons will react with 11B. Each reaction will emit alpha particles according to its reaction cross section. The dose due to these alpha particles, together with the primary proton beam, can induce tumor cell kill. The purpose of this study is to computationally investigate these synergy effects using the Monte Carlo simulation with the target region located in the water medium. A 79.9 MeV proton beam (proton density: 1.9 × 108 cm−2) with 4 monitor unit was used to irradiate the target consisting of water, 10B, 11B, and natural B. The variation of the dose, the location of the reaction, and the energy distribution of the alpha particles were calculated according to the target material. As a result, we confirmed contributions of both BNC and PBF reactions to emitting alpha particles from proton beam irradiation with natural boron. This synergy effect induced an additional 7.29% enhanced dose by 331 984 alpha particles. This enhanced dose can sufficiently reduce the number of treatment fractions in proton therapy.
Neuromuscular performance after rapid weight loss in Olympic‐style boxers
Authors: Zubac Damir , Šimunič Boštjan , Buoite Stella Alex , Morrison Shawnda A.
Published: November 2019

The present study investigated the effect of a 3% rapid weight loss (RWL) procedure on neuromuscular performance in elite, Olympic‐style boxers. Nine boxers were randomly assigned to two experimental procedures (RWL and control, in a randomized counter‐balance order) to perform 5‐s maximum isometric voluntary contractions (MVC) of the dominant leg knee extensors prior to (MVC1), and following (MVC2), a sustained, isometric contraction at 70% MVC until exhaustion. The voluntary activation (VA) was determined using percutaneous muscle stimulation and interpolated twitch technique. High (at 80 Hz) and low (at 20 Hz) frequency tetanic impulses were also delivered before and after the sustained 70% MVC to assess peripheral fatigue. Hydration status, hemodynamic parameters, and lactate concentration were assessed throughout the study. Body‐mass was reduced by ∼3% (during RWL) compared to control (p = .001). As a result of the RWL protocol, MVC1 force output was 12% lower and VA deficits of 7% were observed after the fatigue protocol compared to control (p = .001). Following RWL, time to exhaustion for the sustained 70% MVC was 69 ± 20 s compared to 86 ± 34 s for control (p = .020). Peak lactate production was 53% lower in RWL compared to control (p = .001). In conclusion, the 3% RWL procedure translated into significant decline in neuromuscular performance for both brief and sustained contractions in competitive boxers.
A technique of hydrodynamics and heat transfer research during the flow of liquid metals in channels of various forms
Authors: Yu Pyatnitskaya N , Razuvanov N G , Belyaev I A , Sviridov V G , Genin L G
Published: November 2019

This paper presents probe techniques and sensors used in experimental studies of MHD-flow and heat transfer of liquid metal (LM) in pipes and channels, hosted by the mercury stands, which is part of the MHD complex of MPEI-JIHT RAS. A detailed description of the correlation and conduction velocity measurement methods, as well as the results obtained with their use, are given.
Transient phenomena in the draft tube model of a Francis hydro-turbine
Authors: Suslov D A , Litvinov I V , Gorelikov E U , Shtork S I
Published: November 2019

This article is devoted to the study of pressure pulsations behind the runner of a hydro turbine model caused by the precessing vortex core (PVC). Pressure pulsations are investigated under conditions of stationary load and transient modes of the hydro-turbine operation. Studies were performed in model conditions on the aerodynamic setup. The map of pressure pulsations was built for stationary modes using acoustic sensors and served to find rotational speeds of the swirler and flow rates at which the PVC occurs. On the basis of the data presented by parametric dependences, the initial and final parameters of the transition process were chosen. In the article, a sudden (fast) transition from part-load regime to the best efficiency point and back was considered. The characteristic times for the formation of PVC and the establishment of the flow regime when changing the controlling parameters of the installation have been determined using a continuous wavelet transform.
Numerical simulation of energy separation of low-Prandtl gas mixture flowing in the finned single Leontiev tube
Authors: Makarov M S , Makarova S N
Published: November 2019

The paper presents results of numerical simulation of energy separation (temperature stratification) of helium-xenon gas mixture with low-Prandtl number, flowing in the finned single Leontiev tube. Only the inner surface of the central channel for subsonic part of the flow was finned by longitudinal fins. The influence of the flow rate of the cooling gas, flowing through the central channel, on the energy separation efficiency was analyzed in comparison with the efficiency of Leontiev tube with smooth walls. The method of efficiency enhancement by insulating the low-temperature area at the tube outlet was suggested.
Investigation of the influence of intra-channel liquid film suction on the structure of the droplet flow downstream a stator blades cascade of a steam turbine
Authors: Alekseev R A , Gribin V G , Tishchenko A A , Yu Gavrilov I , Tishchenko V A , Popov V V
Published: November 2019

The work is devoted to the study of the effect of intra-channel liquid film suction on the characteristics of the wet steam flow downstream a stator blades cascade of a steam turbine. The moisture removal system consisted of two slots on the pressure side of the blade. Each slot was connected to an individual suction chamber. The investigations were carried out with a theoretical Mach number downstream the cascade M
1t = 0.78 and an initial steam wetness y
0 = 3%. The main feature of the research was the use of a “PIV-IT” flow laser diagnostics system in which the PTV method was realized. This allowed conducting a detailed study of the structure of a polydisperse wet steam flow. During the investigation an idea of the complex structure of droplets flows downstream the turbine cascade was generated. The analysis of the obtained data allowed us to reveal the main features of the influence of intra-channel liquid film suction on the flows of the liquid particles. It is established that moisture removal does not have a significant effect on the velocity characteristics of the liquid phase. At the same time, the results of studies have shown that intra-channel liquid film suction systems reduce the number of coarse erosion-hazardous droplets downstream a stator blades cascade.
Numerical simulation of the dynamics and calculation of the rheological characteristics of the dispersed systems using BEM
Authors: Abramova O A , Bulatova A Z , Fatkullina N B , Pityuk Yu A
Published: November 2019

Dispersed systems of various types occupy a significant place in nature, technology, and everyday life. Unfailing interest in this field is shown by researchers from the physics and mechanics, colloid chemistry, micro-manufacturing, and biology, which is due to the variety of phenomena and effects associated with dispersed systems of different nature. High-efficient computational techniques for direct modeling of the dispersed system are required to more accurately determine the rheological parameters of such systems, based on the calculated properties of its components. The present work is dedicated to the numerical investigation of the dispersed system features in a shear flow at low Reynolds numbers using the boundary element method. The results of the simulations and the method details are discussed. Calculations are presented for different types of dispersed inclusions. Viscous droplets and rigid particles of different shapes in a volume of carrier viscous liquid are considered. Furthermore, the standard viscometric functions that characterize the behaviour of an emulsion or suspensions, regarded as a homogeneous medium, are calculated and studied.
Numerical simulation of a turbulent boundary layer at the gas/liquid interface
Authors: Goltsman A E , Saushin I I
Published: November 2019

This paper is the numerical study of the boundary layer evolution at gas streamlining of the surface of a standing liquid. The paper presents the results of numerical simulation of a two-phase flow at a moderate dynamic head of gas (about 10 Pa) insufficient for significant deformation of the interphase boundary. Comparison with the nature of the boundary layer in the flow around a solid plate has revealed a number of significant differences. Three characteristic regions of the boundary layer evolution depending on Rex in the range of values from 0 to 320, 000 have been obtained and described.
An early stage of the drop interaction with shock wave: airflow, deformation, destruction
Authors: Poplavski S V , Minakov A V , Shebeleva A A
Published: November 2019

The work is devoted to experimental and computational modeling of the flow around water droplets behind an incident shock wave and its effect on deformation and decay. The structure of the flow near and in the wake of the drop, the evolution of the shape and breakup delay were investigated in the range of shock wave Mach numbers Ms=1.109–1.34 and Weber numbers We=200–2200. Comparison of calculations with experiments allowed constructing a phenomenological picture of the behavior of a drop in shock wave as a response to a rapidly changing flow field at an early stage of interaction.
Study of the features of behaviour of overheated liquid-metal drops in gas media, water and electromagnetic field of the inductor
Authors: Vinogradov D A , Ivochkin Y P , Kubrikov K G , Sinkevich O A , Teplyakov I O
Published: November 2019

A modern experimental setup designed for the melting of liquid-metal samples by the eddy current is described. A new experimental material about the behaviour of drops of the melts in` gas atmospheres (argon, air) and distilled water of room temperature is obtained. It was confirmed that during the heating of a steel drop, that is the main component of corium in case of crashes at the nuclear power plants, in air an intensive spark generation of metal (drop erosion) are observed. The latter prevents the occurrence of the film boiling regime of the coolant and contributes to the prevention of explosive fragmentation of the melt. It is shown that in an inert argon atmosphere such regime does not take place but there is another physical effect that requires additional study and which is behind the ejection of the streams (or departure of drops) of liquid metal from its surface into the surrounding space. The relation between was determined the frequency of departure of coolant (distilled water) vapour bubbles and external pressure and temperature of the heated ball. It was stated that the regime of film boiling with the departure of vapor bubbles is observed only at temperatures over 350 °C. A figure with the changing form of the inter-phase vapor-liquid surface depending on the temperature of the heated body was obtained.
Optimization of stator blade profile design for last stages of steam turbines based on the features of coarse droplets movement in inter-blade channels
Authors: Alekseev R A , Gribin V G , Tishchenko A A , Yu Gavrilov I , Tishchenko V A , Popov V V
Published: November 2019

Results of the investigation of coarse droplets movement in steam turbine blade passages are presented in the paper. The structure of generated streams of secondary droplets was considered. The analysis of the effect of these streams on the liquid film formation on the blade surfaces was performed. On the basis of obtained data, several recommendations for blade design operating in wet steam conditions were formulated. They were used to optimize the baseline profile geometry in order to control the coarse droplets streams and provide the increasing of liquid film suction effectiveness. The numerical and experimental comparison of the baseline and optimized geometries was performed.
Theoretical investigation of nitrogen gas hydrates outside of stability zone
Authors: Zhdanov R K , Gets K V , Bozhko Y Y , Subbotin O S , Belosludov V R
Published: November 2019

Using a combination of Quasiharmonic Lattice Dynamic and Molecular Dynamic Simulation methods in conjunction with well developed statistical thermodynamics theory the thermodynamic properties of nitrogen gas hydrates has been calculated, with the main focus on the thermal expansion coefficient. It is shown that nitrogen gas hydrate displays larger value of the thermal expansion coefficient in comparison with hexagonal ice Ih and empty gas hydrate lattice, moreover this value is very close to one of the carbon dioxide and to other hydrates that have self-preservation effect. Exactly because of this difference in the thermal expansion coefficient it is possible to confirm existence of the self-preservation effect. The self-preservation effect can be used for creation of low-cost technology of hydrates storage and transportation technology applicable for many gas types.
Heat and mass transfer during crystal growing by the Czochralski method with a submerged vibrator
Authors: Fedyushkin A I
Published: November 2019

It was shown that the vibrations can intensify of heat- mass transfer and mixing of the melt, and also to reduce dynamic and temperature boundary layers and to increase a temperature gradient on melt/crystal interface, that can to increase rate of crystal growth by the Czochralski method with a submerged vibrator. It is can be very impotent for manufacturing and quality of crystals.
Sedimentation dynamics of a polydisperse cluster of solid particles in a viscous fluid
Authors: Arkhipov V A , Basalaev S A , Zolotorev N N , Perfilieva K G , Usanina A S
Published: November 2019

Methods and results of experimental studies of the gravitational sedimentation of a consolidated polydisperse system of solid spherical particles in a viscous fluid are presented. The overall picture of motion of the consolidated system of bi-disperse solid spherical particles is obtained. The motion regularities (the cloud evolution, sedimentation rate, and drag coefficient) of a set of solid spherical particles under various flow regimes are investigated. The gravitational sedimentation of monodisperse and bi-disperse consolidated systems of spherical particles in the viscous fluid is compared.
Numerical Simulation of Coaxial Swirled Lifted Propane-Air Flame under Buoyancy Conditions
Authors: Evdokimov O A , Guryanov A I , Veretennikov S V
Published: November 2019

Numerical simulation of gas dynamics and combustion in coaxial swirled lifted propane-air jets under buoyancy conditions is performed. Dependences of dimensionless flame length L/d
0, lift-off height h/d
0 as well as flame front surface area Sfl
and mass rate of burn-out U on orientation angle θ are obtained. The results of numerical simulation and experiment for different values of θ are compared. It is confirmed that in the angle range of 30° < θ < 60° flame has the smallest surface area that provides the highest value of the mass rate of burn-out. The numerical solution closest to an experiment data can be obtained by using an additional differential transport equation for the ignition time or setting a delay time in the range of 0.05..0.25 s.
Numerical study of two-dimensional structure of detonation front in two-fuel mixtures
Authors: Trotsyuk A V
Published: November 2019

The numerical simulation of a two-dimensional multi-front structure of detonation waves (DWs) in two-fuel mixtures has been carried out. These studies are based on the proposed two-stage generalized model of chemical kinetics of detonation combustion of a two-fuel mixture: hydrogen and carbon monoxide (synthesis gas) with an oxidizer. This kinetics allowed performing for the first time a two-dimensional numerical calculation of the DW parameters and the irregular cellular front structure in this two-fuel mixture at various concentrations of hydrogen. Stoichiometric compositions with oxygen and air as oxidizing agents have been studied. The transverse sizes of detonation cells in the studied mixtures have been obtained. The decrease in the hydrogen concentration leads to a significant increase of the cell size and an increase of the degree of irregularity of DW multi-front structure.
Comparison of crystallization behavior in a drop and in a thin layer of an aqueous salt solution of LiBr during non-isothermal desorption
Authors: Misyura S Y , Morozov V S
Published: November 2019

An experimental study of the motion of the crystal front and the crystallization rate for a drop and a layer of an aqueous salt solution of LiBr was carried out. The nature of the crystal front motion depends on the initial salt concentration. For most of the crystallization time, the crystallization rate J
cr is many times higher for a drop than for a thin layer. For the final crystallization stage, J
cr is higher for the drop. Different crystallization kinetics is associated with a change in the place of origin of the first crystalline center, as well as with features of the temperature distribution on the free surface of the salt solution.
Study of the formation of the Black Sea haline stratification from the numerical simulations
Authors: Senderov M V , Mizyuk A I , Korotaev G K
Published: November 2019

The excess of river runoff and precipitation over evaporation (positive freshwater balance) and the supply of the Marmara Sea highly saline waters through the Bosphorus is the cause of the sharp halocline in the 100-300 m layer and low vertical mixing in the permanent pycnocline layer, where the contribution salinity to the seawater density prevails compared to temperature. Such features of the Black Sea waters make the description of the process of formation of the haline stratification an actual and inexhausted problem. Investigating the patterns of the formation of the haline stratification in the Black Sea, a laboratory model of a rotating cylindrical cavity and a numerical model are proposed. Laboratory studies have shown that in a simple configuration, the buoyancy flux across the basin boundaries leads to the formation of a sharp pycnocline and the formation of a three-layer vertical structure of horizontal currents. Numerical experiments demonstrate that halocline is formed at a depth of 10-40 m. The haline stratification has been established with a pronounced halocline for about hundred years which later slowly evolved.
Numerical modeling of the Kolmogorov flow in a viscous and inviscid media
Authors: Fortova S V , Oparina E I , Doludenko A N
Published: November 2019

In this paper we consider the problem proposed by A.N. Kolmogorov to study the reasons of turbulence. We consider the action of the external periodic field along one of the coordinates on a viscous and inviscid conductive media in the two-dimensional case. We propose a numerical study of this problem based on the solution of the systems of the Euler and mainly the Navier-Stokes equations. The calculations show that under certain conditions periodic vortex structures may appear in the liquid, similar to the “parquet” mode in the Kolmogorov task, with the subsequent development of the self-similar regime.