bluuebunny/crossref_metadata_2025 huggingface dataset:
The Origin of X-ray Emission from the Enigmatic Be Star γ Cassiopeiae
Authors: Hamaguchi K. , Oskinova L. , Russell C. M. P. , Petre R. , Enoto T. , Morihana K. , Ishida M.
Published: July 2017

Gamma Cassiopeiae is an enigmatic Be star with unusually hard, strong X-ray emission compared with normal main-sequence B stars. The origin has been debated for decades between two theories: mass accretion onto a hidden compact companion and a magnetic dynamo driven by the star-Be disk differential rotation. There has been no decisive signature found that supports either theory, such as a pulse in X-ray emission or the presence of large-scale magnetic field. In a ~100 ksec duration observation of the star with the Suzaku X-ray observatory in 2011, we detected six rapid X-ray spectral hardening events called “softness dips”. All the softness dip events show symmetric softness ratio variations, and some of them have flat bottoms apparently due to saturation. The softness dip spectra are best described by either ~40% or ~70% partial covering absorption to kT ~12 keV plasma emission by matter with a neutral hydrogen column density of ~2 − 8 × 1021cm−2, while the spectrum outside of these dips is almost free of absorption. This result suggests that two distinct X-ray emitting spots in the γ Cas system, perhaps on a white dwarf companion with dipole mass accretion, are occulted by blobs in the Be stellar wind, the Be disk, or rotating around the white dwarf companion. The formation of a Be star and white dwarf binary system requires mass transfer between two stars; γ Cas may have experienced such activity in the past.
Not so lonely: The LBV binary HR Car
Authors: Rivinius T. , Boffin H. M. J. , Mérand A. , Mehner A. , LeBouquin J.-B. , Pourbaix D. , de Wit W.-J. , Martayan C.
Published: July 2017

Luminous Blue Variables (LBVs) are a brief phase in the evolution of massive stars, but a very important one. The giant eruptions remain enigmatic, but the discovery of the flagship LBV η Car to be a five-year highly eccentric binary put focus on possible binarity induced mechanism for these outbursts, and prompted binarity searches among LBVs. While several wide LBV binaries were identified, HR Car is the first system found to be similar to η Car, i.e., relatively close & eccentric.
New runaway O-type stars in the first Gaia Data Release
Authors: Maíz Apellániz Jesús , Barbá Rodolfo H. , Simón-Díaz Sergio , Negueruela Ignacio , Trigueros Páez Emilio
Published: July 2017

We have detected 13 new runaway-star candidates of spectral type O combining the TGAS (Tycho-Gaia Astrometric Solution) proper motions from Gaia Data Release 1 (DR1) and the sample from GOSSS (Galactic O-Star Spectroscopic Survey). We have also combined TGAS and Hipparcos proper motions to check that our technique recovers many of the previously known O-type runaways in the sample.
The Search for Wolf-Rayet Stars in IC10
Authors: Tehrani Katie , Crowther Paul , Archer Isabelle
Published: July 2017

We present a deep imaging and spectroscopic survey of the Local Group starburst galaxy IC10 using Gemini North/GMOS to unveil the global Wolf-Rayet population. It has previously been suggested that for IC10 to follow the WC/WN versus metallicity dependence seen in other Local Group galaxies, a large WN population must remain undiscovered. Our search revealed 3 new WN stars, and 5 candidates awaiting confirmation, providing little evidence to support this claim. We also compute an updated nebular derived metallicity of log(O/H)+12=8.40 ± 0.04 for the galaxy using the direct method. Inspection of IC10 WR average line luminosities show these stars are more similar to their LMC, rather than SMC counterparts.
New Solutions to Line-Driven Winds of Hot Massive Stars
Authors: Gormaz-Matamala Alex C. , Curé Michel , Cidale Lydia , Venero Roberto
Published: July 2017

In the frame of radiation driven wind theory (Castor et al.1975), we present self-consistent hydrodynamical solutions to the line-force parameters (k, α, δ) under LTE conditions. Hydrodynamic models are provided by HydWind (Curé 2004). We evaluate these results with those ones previously found in literature, focusing in different regions of the optical depth to be used to perform the calculations. The values for mass-loss rate and terminal velocity obtained from our calculations are also presented.

We also examine the line-force parameters for the case when large changes in ionization throughout the wind occurs (δ-slow solutions, Curé et al.2011).
Re-examing the Upper Mass Limit of Very Massive Stars: VFTS 682, an isolated ~130 M⊙ twin of R136’s WN5h core stars
Authors: Rubio-Díez M. M. , Najarro F. , García M. , Sundqvist J. O.
Published: July 2017

Recent studies of WNh stars at the cores of young massive clusters have challenged the previously accepted upper stellar mass limit (~150 M⊙), suggesting some of these objects may have initial masses as high as 300 M⊙. We investigated the possible existence of observed stars above ~150 M⊙ by i) examining the nature and stellar properties of VFTS 682, a recently identified WNh5 very massive star, and ii) studying the uncertainties in the luminosity estimates of R136’s core stars due to crowding. Our spectroscopic analysis reveals that the most massive members of R136 and VFTS 682 are very similar and our K-band photometric study of R136’s core stars shows that the measurements seem to display higher uncertainties than previous studies suggested; moreover, for the most massive stars in the cluster, R136a1 and a2, we found previous magnitudes were underestimated by at least 0.4 mag. As such, luminosities and masses of these stars have to be significantly scaled down, which then also lowers the hitherto observed upper mass limit of stars.
Magneto-asteroseismology of massive magnetic pulsators
Authors: Buysschaert B. , Neiner C. , Aerts C.
Published: July 2017

Simultaneously and coherently studying the large-scale magnetic field and the stellar pulsations of a massive star provides strong complementary diagnostics suitable for detailed stellar modelling. This hybrid method is called magneto-asteroseismology and permits the determination of the internal structure and conditions within magnetic massive pulsators, for example the effect of magnetism on non-standard mixing processes. Here, we overview this technique, its requirements, and list the currently known suitable stars to apply the method.
B-supergiants in IC1613: testing low-Z massive star physics and evolution
Authors: Camacho Inés , García Miriam , Urbaneja Miguel A. , Herrero Artemio
Published: July 2017

The physical processes taking place in massive stars during their life and death are highly dependent on the metallicity (Z) of their parent cloud. Observations of these stars in low-Z nearby galaxies are crucial to understand these processes. IC1613 is the nearest Local Group galaxy with ongoing star formation and O-abundance lower than the SMC, although UV spectroscopy suggests it is not so metal poor. We performed a spectral analysis of early B-type stars in the galaxy, obtaining physical parameters and abundances. Our results confirm the low O-abundance of IC1613.
Core-Collapse Supernovae in the Early Universe: Radiation Hydrodynamics Simulations of Multicolor Light Curves
Authors: Tolstov Alexey , Nomoto Ken’ichi , Tominaga Nozomu , Ishigaki Miho , Blinnikov Sergei , Suzuki Tomoharu
Published: July 2017

The properties of the first generation of stars and their supernova (SN) explosions remain unknown due to the lack of their actual observations. Pop III stars may have been very massive and predicted to be exploded as pair-instability SNe, but the observed metal-poor stars show the abundance patterns which are more consistent with yields of core-collapse SNe. We study the multicolor light curves for a metal-free core-collapse SN models (massive stars of 25-100 solar mass range) to determine the indicators for the detection and identification of first generation SNe. We use mixing-fallback supernova explosion models which explain the observed abundance patterns of metal poor stars. Numerical calculations of the multicolor light curves are performed using the multigroup radiation hydrodynamic code STELLA. The calculated light curves of metal-free SNe are compared with our calculations of non-zero metallicity models and observed SNe.
The Ages of High-Mass X-ray Binaries in M33
Authors: Garofali Kristen , Williams Benjamin F.
Published: July 2017

We present initial results on a survey of high-mass X-ray binaries (HMXBs) in the nearby, star-forming spiral galaxy M33. The HMXB population in M33 is identified and characterized using a combination of deep Chandra X-ray imaging and archival Hubble Space Telescope (HST) observations. We determine ages for the HMXBs to ~5 Myr precision from fits to the color-magnitude diagrams (CMDs) of the surrounding stars and the resultant star formation histories (SFHs). The HMXBs in our M33 sample have measured ages, as well as candidate optical counterparts identified from HST photometry.
The 2D dynamics of the differentially rotating envelope of massive stars
Authors: Hypolite Delphine , Mathis Stéphane , Rieutord Michel
Published: July 2017

We build a 2D model of the radiative envelope of main sequence massive stars. We set a dynamical boundary condition at the bottom of the radiative envelope at η = rC/R (where rC is the core size and R the radius of the star) to account for the differential rotation of the convective core as computed in 3D simulations (e.g. Browning et al. (2004, IAUS, 224, 149). We seek the differential rotation and associated meridional circulation induced by such a shear competing with the baroclinic flow of the stably stratified radiative envelope using the Boussinesq approximation.
Blue supergiant progenitors from binary mergers for SN 1987A and other Type II-peculiar supernovae
Authors: Menon Athira , Heger Alexander
Published: July 2017

We present results of a systematic and detailed stellar evolution study of binary mergers for blue supergiant (BSG) progenitors of Type II supernovae, particularly for SN 1987A. We are able to reproduce nearly all observational aspects of the progenitor of SN 1987A, Sk –69 °202, such as its position in the HR diagram, the enrichment of helium and nitrogen in the triple-ring nebula and its lifetime before its explosion. We build our evolutionary model based on the merger model of Podsiadlowski et al. (1992), Podsiadlowski et al. (2007) and empirically explore an initial parameter consisting of primary masses, secondary masses and different depths up to which the secondary penetrates the He core during the merger. The evolution of the post-merger star is continued until just before iron-core collapse. Of the 84 pre-supernova models (16 M⊙ − 23 M⊙) computed, the majority of the pre-supernova models are compact, hot BSGs with effective temperature >12 kK and 30 R⊙ − 70 R⊙ of which six match nearly all the observational properties of Sk –69 °202.
Analysis and fit of stellar spectra using a mega-database of CMFGEN models
Authors: Fierro-Santillán Celia , Zsargó Janos , Klapp Jaime , Díaz-Azuara Santiago Alfredo , Arrieta Anabel , Arias Lorena
Published: July 2017

We present a tool for analysis and fit of stellar spectra using a mega database of 15,000 atmosphere models for OB stars. We have developed software tools, which allow us to find the model that best fits to an observed spectrum, comparing equivalent widths and line ratios in the observed spectrum with all models of the database. We use the Hα, Hβ, Hγ, and Hδ lines as criterion of stellar gravity and ratios of He II λ4541/He I λ4471, He II λ4200/(He I+He II λ4026), He II λ4541/He I λ4387, and He II λ4200/He I λ4144 as criterion of Teff.
CFHT/SITELLE Observations of the Ejected WR Nebula M1-67
Authors: St-Louis N. , Sévigny M. , Drissen L. , Martin T.
Published: July 2017

We present preliminary results of Sitelle observations of the M1-67 nebula surrounding the Wolf-Rayed stars WR 124.
Highly accurate quantitative spectroscopy of massive stars in the Galaxy
Authors: Nieva María-Fernanda , Przybilla Norbert
Published: July 2017

Achieving high accuracy and precision in stellar parameter and chemical composition determinations is challenging in massive star spectroscopy. On one hand, the target selection for an unbiased sample build-up is complicated by several types of peculiarities that can occur in individual objects. On the other hand, composite spectra are often not recognized as such even at medium-high spectral resolution and typical signal-to-noise ratios, despite multiplicity among massive stars is widespread. In particular, surveys that produce large amounts of automatically reduced data are prone to oversight of details that turn hazardous for the analysis with techniques that have been developed for a set of standard assumptions applicable to a spectrum of a single star. Much larger systematic errors than anticipated may therefore result because of the unrecognized true nature of the investigated objects, or much smaller sample sizes of objects for the analysis than initially planned, if recognized. More factors to be taken care of are the multiple steps from the choice of instrument over the details of the data reduction chain to the choice of modelling code, input data, analysis technique and the selection of the spectral lines to be analyzed. Only when avoiding all the possible pitfalls, a precise and accurate characterization of the stars in terms of fundamental parameters and chemical fingerprints can be achieved that form the basis for further investigations regarding e.g. stellar structure and evolution or the chemical evolution of the Galaxy. The scope of the present work is to provide the massive star and also other astrophysical communities with criteria to evaluate the quality of spectroscopic investigations of massive stars before interpreting them in a broader context. The discussion is guided by our experiences made in the course of over a decade of studies of massive star spectroscopy ranging from the simplest single objects to multiple systems.
Binary Population and Spectral Synthesis
Authors: Eldridge J. J. , Stanway E. R. , Xiao L. , McClelland L. A. S. , Bray J. C. , Taylor G. , Ng M.
Published: July 2017

We have recently released version 2.0 of the Binary Population and Spectral Synthesis (BPASS) population synthesis code. This is designed to construct the spectra and related properties of stellar populations built from ~200,000 detailed, individual stellar models of known age and metallicity. The output products enable a broad range of theoretical predictions for individual stars, binaries, resolved and unresolved stellar populations, supernovae and their progenitors, and compact remnant mergers. Here we summarise key applications that demonstrate that binary populations typically reproduce observations better than single star models.
The multiplicity of massive stars: a 2016 view
Authors: Sana Hugues
Published: July 2017

Massive stars like company. Here, we provide a brief overview of progresses made over the last 5 years by a number of medium and large surveys. These results provide new insights on the observed and intrinsic multiplicity properties of main sequence massive stars and on the initial conditions for their future evolution. They also bring new interesting constraints on the outcome of the massive star formation process.
Clumping in stellar winds and interiors
Authors: Gräfener Götz
Published: July 2017

The uncertain clumping properties pose a major problem for the quantitative analysis and the modelling of hot star winds. New results suggest that also the outer envelopes of massive stars may be affected by clumping, with important consequences for their observable radii and ionising properties. In this talk I will discuss how clumping is incorporated in stellar interior and wind/atmosphere models, how current theoretical results compare with observations, and what we can learn from a combination of stellar interior models and winds.
High angular resolution radio and infrared view of optically dark supernovae in luminous infrared galaxies
Authors: Mattila Seppo , Kankare Erkki , Kool Erik , Romero-Cañizales Cristina , Ryder Stuart , Perez-Torres Miguel
Published: July 2017

In luminous and ultraluminous infrared galaxies (U/LIRGs), the infall of gas into the central regions strongly enhances the star formation rate (SFR), especially within the nuclear regions which have also large amounts of interstellar dust. Within these regions SFRs of several tens to hundreds of solar masses per year ought to give rise to core-collapse supernova (SN) rates up to 1-2 SNe every year per galaxy. However, the current SN surveys, almost exclusively being ground-based seeing-limited and working at optical wavelengths, have been blinded by the interstellar dust and contrast issues therein. Thus the properties and rates of SNe in the nuclear environments of the most prolific SN factories in the Universe have remained largely unexplored. Here, we present results from high angular resolution observations of nearby LIRGs at infrared and radio wavelengths much less affected by the effects of extinction and lack of resolution hampering the optical searches.
The evolution of red supergiants to supernovae
Authors: Beasor Emma R. , Davies Ben
Published: July 2017

With red supergiants (RSGs) predicted to end their lives as Type IIP core collapse supernova (CCSN), their behaviour before explosion needs to be fully understood. Mass loss rates govern RSG evolution towards SN and have strong implications on the appearance of the resulting explosion. To study how the mass-loss rates change with the evolution of the star, we have measured the amount of circumstellar material around 19 RSGs in a coeval cluster. Our study has shown that mass loss rates ramp up throughout the lifetime of an RSG, with more evolved stars having mass loss rates a factor of 40 higher than early stage RSGs. Interestingly, we have also found evidence for an increase in circumstellar extinction throughout the RSG lifetime, meaning the most evolved stars are most severely affected. We find that, were the most evolved RSGs in NGC2100 to go SN, this extra extinction would cause the progenitor’s initial mass to be underestimated by up to 9M⊙.
The VLT/X-shooter GRB afterglow legacy survey
Authors: Kaper Lex , Fynbo Johan P.U. , Pugliese Vanna , van Rest Daan
Published: July 2017

The Swift satellite allows us to use gamma-ray bursts (GRBs) to peer through the hearts of star forming galaxies through cosmic time. Our open collaboration, representing most of the active European researchers in this field, builds a public legacy sample of GRB X-shooter spectroscopy while Swift continues to fly. To date, our spectroscopy of more than 100 GRB afterglows covers a redshift range from 0.059 to about 8 (Tanvir et al. 2009, Nature 461, 1254), with more than 20 robust afterglow-based metallicity measurements (over a redshift range from 1.7 to 5.9). With afterglow spectroscopy (throughout the electromagnetic spectrum from X-rays to the sub-mm) we can hence characterize the properties of star-forming galaxies over cosmic history in terms of redshift, metallicity, molecular content, ISM temperature, UV-flux density, etc.. These observations provide key information on the final evolution of the most massive stars collapsing into black holes, with the potential of probing the epoch of the formation of the first (very massive) stars.

VLT/X-shooter (Vernet et al. 2011, A&A 536, A105) is in many ways the ideal GRB follow-up instrument and indeed GRB follow-up was one of the primary science cases behind the instrument design and implementation. Due to the wide wavelength coverage of X-shooter, in the same observation one can detect molecular H2 absorption near the atmospheric cut-off and many strong emission lines from the host galaxy in the near-infrared (e.g., Friis et al. 2015, MNRAS 451, 167). For example, we have measured a metallicity of 0.1 Z⊙ for GRB 100219A at z = 4.67 (Thöne et al. 2013, MNRAS 428, 3590), 0.02 Z⊙ for GRB 111008A at z = 4.99 (Sparre et al. 2014, ApJ 785, 150) and 0.05 Z⊙ for GRB 130606A at z = 5.91 (Hartoog et al. 2015, A&A 580, 139). In the latter, the very high value of [Al/Fe]=2.40 ± 0.78 might be due to a proton capture process and may be a signature of a previous generation of massive (perhaps even the first) stars. Reconciling the abundance patterns of GRB absorbers, other types of absorbers (in particular QSO DLAs), and old stars in the Local Group is an important long-term goal of this program (see Sparre et al. 2014, ApJ 785, 150). Metallicities are also measured from host emission lines (Krühler et al. 2015, A&A 581, A125). GRB spectroscopy also allows us to determine the dust content of their environments, both through analysis of the depletion pattern and the measurement of the associated extinction (Japelj et al. 2015, A&A 451, 2050). This way one can quantify the dust-to-metals ratio and its evolution with redshift. The detection of GRBs at z > 6 shows that GRBs have become competitive as a tool to identifying galaxies at the highest redshifts and unsurpassed in providing detailed abundance information via absorption line spectroscopy.
II Zw 40 – 30 Doradus on Steroids
Authors: Leitherer Claus , Lee Janice C. , Levesque Emily M.
Published: July 2017

We obtained HST COS G140L spectra of the enigmatic nearby blue compact dwarf galaxy II Zw 40. The galaxy hosts a nuclear super star cluster embedded in a radio-bright nebula, similar to those observed in the related blue compact dwarfs NGC 5253 and Henize 2-10. The ultraviolet spectrum of II Zw 40 is exceptional in terms of the strength of He II 1640, O III] 1666 and C III] 1909. We determined reddening, age, and the cluster mass from the ultraviolet data. The super nebula and the ionizing cluster exceed the ionizing luminosity and stellar mass of the local benchmark 30 Doradus by an order of magnitude. Comparison with stellar evolution models accounting for rotation reveals serious short-comings: these models do not account for the presence of Wolf-Rayet-like stars at young ages observed in II Zw 40. Photoionization modeling is used to probe the origin of the nebular lines and determine gas phase abundances. C/O is solar, in agreement with the result of the stellar-wind modeling.
X-ray Emission from Massive Stars at the Core of Very Young Clusters
Authors: Schulz Norbert S.
Published: July 2017

Most cores of very young stellar clusters contain one or more massive stars at various evolutionary stages. Observations of the Orion Nebula Cluster, Trumpler 37, NGC 2362, RCW38, NGC 3603 and many others provide the most comprehensive database to study stellar wind properties of these massive cluster stars in X-rays. In this presentation we review some of these observations and results and discuss them in the context of stellar winds and possible evolutionary implications. We argue that in very young clusters such as RCW38 and M17, shock heated remnants of a natal shell could serve as an alternate explanation to the colliding wind paradigm for the hot plasma components in the X-ray spectra.
WR 148 and the not so compact companion
Authors: Munoz Melissa , Moffat Anthony J. , Hill Grant M. , Shenar Tomer , Richardson Noel D. , Pablo Herbert , St-Louis Nicole , Ramiaramanantsoa Tahina
Published: July 2017

The objective is to determine the nature of the unseen companion of the single-lined spectroscopic binary, WR 148 (= WN7h+?). The absence of companion lines supports a compact companion (cc) scenario. The lack of hard X-rays favours a non-compact companion scenario. Is WR 148 a commonplace WR+OB binary or a rare WR+cc binary?
Conceptual Issues and Assessment of Implicit Theories
Authors: Lüftenegger Marko , Chen Jason A.
Published: July 2017

Abstract. We reviewed fundamental conceptual issues and the state of research on the definition and assessment of implicit theories. We grappled with the following controversies related to the construct: (a) Are entity theory and incremental theory opposite ends of the same continuum? (b) How can scholars use more sophisticated methodologies to classify individuals into either the entity or incremental theory? (c) Given shifting conceptions of what intelligence is, how can scholars refine the implicit theory of intelligence construct? Given these conceptual issues, we then addressed practical issues related to the assessment of implicit theories. We point to the need for more sophisticated methods such as implicit association tests and the use of virtual environments as more “stealthy” ways to assess the construct.
Freeform spectrometer enabling increased compactness
Authors: Reimers Jacob , Bauer Aaron , Thompson Kevin P , Rolland Jannick P
Published: July 2017

We present optical designs with freeform optics in the context of hyperspectral imaging. Results show designs that are 5 × more compact in volume than similar designs using conventional spherical or aspherical surfaces. We will show how combining the concepts of spatial and spectral-band broadening, which will be introduced in this paper, led to the improvement in compactness that is uniquely enabled by freeform optics.
Electromagnetic reprogrammable coding-metasurface holograms
Authors: Li Lianlin , Jun Cui Tie , Ji Wei , Liu Shuo , Ding Jun , Wan Xiang , Bo Li Yun , Jiang Menghua , Qiu Cheng-Wei , Zhang Shuang
Published: July 2017

Metasurfaces have enabled a plethora of emerging functions within an ultrathin dimension, paving way towards flat and highly integrated photonic devices. Despite the rapid progress in this area, simultaneous realization of reconfigurability, high efficiency, and full control over the phase and amplitude of scattered light is posing a great challenge. Here, we try to tackle this challenge by introducing the concept of a reprogrammable hologram based on 1-bit coding metasurfaces. The state of each unit cell of the coding metasurface can be switched between ‘1’ and ‘0’ by electrically controlling the loaded diodes. Our proof-of-concept experiments show that multiple desired holographic images can be realized in real time with only a single coding metasurface. The proposed reprogrammable hologram may be a key in enabling future intelligent devices with reconfigurable and programmable functionalities that may lead to advances in a variety of applications such as microscopy, display, security, data storage, and information processing.
Broadband achromatic optical metasurface devices
Authors: Wang Shuming , Wu Pin Chieh , Su Vin-Cent , Lai Yi-Chieh , Hung Chu Cheng , Chen Jia-Wern , Lu Shen-Hung , Chen Ji , Xu Beibei , Kuan Chieh-Hsiung , Li Tao , Zhu Shining , Tsai Din Ping
Published: July 2017

Among various flat optical devices, metasurfaces have presented their great ability in efficient manipulation of light fields and have been proposed for variety of devices with specific functionalities. However, due to the high phase dispersion of their building blocks, metasurfaces significantly suffer from large chromatic aberration. Here we propose a design principle to realize achromatic metasurface devices which successfully eliminate the chromatic aberration over a continuous wavelength region from 1200 to 1680 nm for circularly-polarized incidences in a reflection scheme. For this proof-of-concept, we demonstrate broadband achromatic metalenses (with the efficiency on the order of ∼12%) which are capable of focusing light with arbitrary wavelength at the same focal plane. A broadband achromatic gradient metasurface is also implemented, which is able to deflect wide-band light by the same angle. Through this approach, various flat achromatic devices that were previously impossible can be realized, which will allow innovation in full-color detection and imaging.
Therapeutic radiation for childhood cancer drives structural aberrations of NF2 in meningiomas
Authors: Agnihotri Sameer , Suppiah Suganth , Tonge Peter D. , Jalali Shahrzad , Danesh Arnavaz , Bruce Jeffery P. , Mamatjan Yasin , Klironomos George , Gonen Lior , Au Karolyn , Mansouri Sheila , Karimi Sharin , Sahm Felix , von Deimling Andreas , Taylor Michael D. , Laperriere Normand J. , Pugh Trevor J. , Aldape Kenneth D. , Zadeh Gelareh
Published: July 2017

Cranial radiotherapy improves survival of the most common childhood cancers, including brain tumors and leukemia. Unfortunately, long-term survivors are faced with consequences of secondary neoplasia, including radiation-induced meningiomas (RIMs). We characterized 31 RIMs with exome/NF2 intronic sequencing, RNA sequencing and methylation profiling, and found NF2 gene rearrangements in 12/31 of RIMs, an observation previously unreported in sporadic meningioma (SM). Additionally, known recurrent mutations characteristic of SM, including AKT1, KLF4, TRAF7 and SMO, were not observed in RIMs. Combined losses of chromosomes 1p and 22q were common in RIMs (16/18 cases) and overall, chromosomal aberrations were more complex than that observed in SM. Patterns of DNA methylation profiling supported similar cell of origin between RIMs and SMs. The findings indicate that the mutational landscape of RIMs is distinct from SMs, and have significant therapeutic implications for survivors of childhood cranial radiation and the elucidation of the molecular pathogenesis of meningiomas.
Structural basis of Notch O-glucosylation and O–xylosylation by mammalian protein–O-glucosyltransferase 1 (POGLUT1)
Authors: Li Zhijie , Fischer Michael , Satkunarajah Malathy , Zhou Dongxia , Withers Stephen G. , Rini James M.
Published: July 2017

ProteinO-glucosyltransferase 1/Rumi-mediated glucosylation of Notch epidermal growth factor-like (EGF-like) domains plays an important role in Notch signaling. ProteinO-glucosyltransferase 1 shows specificity for folded EGF-like domains, it can only glycosylate serine residues in the C1XSXPC2motif, and it possesses an uncommon dual donor substrate specificity. Using several EGF-like domains and donor substrate analogs, we have determined the structures of human ProteinO-glucosyltransferase 1 substrate/product complexes that provide mechanistic insight into the basis for these properties. Notably, we show that ProteinO-glucosyltransferase 1’s requirement for folded EGF-like domains also leads to its serine specificity and that two distinct local conformational states are likely responsible for its ability to transfer both glucose and xylose. We also show that ProteinO-glucosyltransferase 1 possesses the potential to xylosylate a much broader range of EGF-like domain substrates than was previously thought. Finally, we show that ProteinO-glucosyltransferase 1 has co-evolved with EGF-like domains of the type found in Notch.
Retrograde BDNF to TrkB signaling promotes synapse elimination in the developing cerebellum
Authors: Choo Myeongjeong , Miyazaki Taisuke , Yamazaki Maya , Kawamura Meiko , Nakazawa Takanobu , Zhang Jianling , Tanimura Asami , Uesaka Naofumi , Watanabe Masahiko , Sakimura Kenji , Kano Masanobu
Published: July 2017

Elimination of early-formed redundant synapses during postnatal development is essential for functional neural circuit formation. Purkinje cells (PCs) in the neonatal cerebellum are innervated by multiple climbing fibers (CFs). A single CF is strengthened whereas the other CFs are eliminated in each PC dependent on postsynaptic activity in PC, but the underlying mechanisms are largely unknown. Here, we report that brain-derived neurotrophic factor (BDNF) from PC facilitates CF synapse elimination. By PC-specific deletion of BDNF combined with knockdown of BDNF receptors in CF, we show that BDNF acts retrogradely on TrkB in CFs, and facilitates elimination of CF synapses from PC somata during the third postnatal week. We also show that BDNF shares signaling pathway with metabotropic glutamate receptor 1, a key molecule that triggers a canonical pathway for CF synapse elimination. These results indicate that unlike other synapses, BDNF mediates punishment signal for synapse elimination in the developing cerebellum.
Unraveling a tumor type-specific regulatory core underlying E2F1-mediated epithelial-mesenchymal transition to predict receptor protein signatures
Authors: Khan Faiz M. , Marquardt Stephan , Gupta Shailendra K. , Knoll Susanne , Schmitz Ulf , Spitschak Alf , Engelmann David , Vera Julio , Wolkenhauer Olaf , Pützer Brigitte M.
Published: July 2017

Cancer is a disease of subverted regulatory pathways. In this paper, we reconstruct the regulatory network around E2F, a family of transcription factors whose deregulation has been associated to cancer progression, chemoresistance, invasiveness, and metastasis. We integrate gene expression profiles of cancer cell lines from two E2F1-driven highly aggressive bladder and breast tumors, and use network analysis methods to identify the tumor type-specific core of the network. By combining logic-based network modeling, in vitro experimentation, and gene expression profiles from patient cohorts displaying tumor aggressiveness, we identify and experimentally validate distinctive, tumor type-specific signatures of receptor proteins associated to epithelial–mesenchymal transition in bladder and breast cancer. Our integrative network-based methodology, exemplified in the case of E2F1-induced aggressive tumors, has the potential to support the design of cohort- as well as tumor type-specific treatments and ultimately, to fight metastasis and therapy resistance.
Discovery and ramifications of incidental Magnéli phase generation and release from industrial coal-burning
Authors: Yang Yi , Chen Bo , Hower James , Schindler Michael , Winkler Christopher , Brandt Jessica , Di Giulio Richard , Ge Jianping , Liu Min , Fu Yuhao , Zhang Lijun , Chen Yuru , Priya Shashank , Hochella Michael F.
Published: July 2017

Coal, as one of the most economic and abundant energy sources, remains the leading fuel for producing electricity worldwide. Yet, burning coal produces more global warming CO2 relative to all other fossil fuels, and it is a major contributor to atmospheric particulate matter known to have a deleterious respiratory and cardiovascular impact in humans, especially in China and India. Here we have discovered that burning coal also produces large quantities of otherwise rare Magnéli phases (Ti
x
O2x–1 with 4 ≤ x ≤ 9) from TiO2 minerals naturally present in coal. This provides a new tracer for tracking solid-state emissions worldwide from industrial coal-burning. In its first toxicity testing, we have also shown that nanoscale Magnéli phases have potential toxicity pathways that are not photoactive like TiO2 phases, but instead seem to be biologically active without photostimulation. In the future, these phases should be thoroughly tested for their toxicity in the human lung.
Risk stratification with Breast Cancer Index for late distant recurrence in patients with clinically low-risk (T1N0) estrogen receptor-positive breast cancer
Authors: Schroeder Brock , Zhang Yi , Stål Olle , Fornander Tommy , Brufsky Adam , Sgroi Dennis C. , Schnabel Catherine A.
Published: July 2017

Patients with early-stage, hormone receptor–positive breast cancer with favorable clinicopathologic features are often not recommended for extended endocrine therapy. However, even patients with T1N0 disease remain at significant risk of distant recurrence up to 15 years following 5 years of endocrine therapy, highlighting the need for further stratification based on individualized risk to select patients for extended endocrine therapy. In this study, the incremental utility of genomic classification to stratify clinically low-risk patients for late distant recurrence was evaluated using the Breast Cancer Index. In 547 T1N0 patients from two cohorts that were disease-free at 5 years post-diagnosis, Breast Cancer Index categorized 32 and 36% from each cohort, respectively, with high risk of late distant recurrence that was associated with significantly reduced distant recurrence-free survival (86.7 and 89.6%) between years 5–15 and 5–10 compared to Breast Cancer Index low risk (95.4%; P = 0.0263 and 98.4%; P = 0.008). Findings support consideration of genomic classification in clinically low-risk hormone receptor–positive patients to identify candidates for extended endocrine therapy.
On the influence of interface charging dynamics and stressing conditions in strained silicon devices
Authors: Olivares Irene , Angelova Todora , Sanchis Pablo
Published: July 2017

The performance of strained silicon devices based on the deposition of a top silicon nitride layer with high stress have been thoroughly analyzed by means of simulations and experimental results. Results clearly indicate that the electro-optic static response is basically governed by carrier effects. A first evidence is the appearance of a variable optical absorption with the applied voltage that should not occur in case of having a purely electro-optic Pockels effect. However, hysteresis and saturation effects are also observed. We demonstrate that such effects are mainly due to the carrier trapping dynamics at the interface between the silicon and the silicon nitride and their influence on the silicon nitride charge. This theory is further confirmed by analyzing identical devices but with the silicon nitride cladding layer optimized to have intrinsic stresses of opposite sign and magnitude. The latter is achieved by a post annealing process which produces a defect healing and consequently a reduction of the silicon nitride charge. Raman measurements are also carried out to confirm the obtained results.
Deoxyarbutin displays antitumour activity against melanoma in vitro and in vivo through a p38-mediated mitochondria associated apoptotic pathway
Authors: Ma Limei , Xu Yao , Wei Zeliang , Xin Guang , Xing Zhihua , Niu Hai , Huang Wen
Published: July 2017

Deoxyarbutin (DeoxyArbutin, dA), a natural compound widely used in skin lighting, displayed selectively cytotoxicity in vitro. In the study, we found that dA significantly inhibited viability/proliferation of B16F10 melanoma cells, induced tumour cell arrest and apoptosis. Furthermore, dA triggered its pro-apoptosis through damaging the mitochondrial function (membrane potential loss, ATP depletion and ROS overload generation etc.) and activating caspase-9, PARP, caspase-3 and the phosphorylation of p38. Treatment with p38 agonist confirmed the involvement of p38 pathway triggered by dA in B16F10 cells. The in vivo finding also revealed that administration of dA significantly decreased the tumour volume and tumour metastasis in B16F10 xenograft model by inhibiting tumour proliferation and inducing tumour apoptosis. Importantly, the results indicated that dA was specific against tumour cell lines and had no observed systemic toxicity in vivo. Taken together, our study demonstrated that dA could combate tumour in vitro and in vivo by inhibiting the proliferation and metastasis of tumour via a p38-mediated mitochondria associated apoptotic pathway.
An analysis of signal processing algorithm performance for cortical intrinsic optical signal imaging and strategies for algorithm selection
Authors: Turley J. A. , Zalewska K. , Nilsson M. , Walker F. R. , Johnson S. J.
Published: July 2017

Intrinsic Optical Signal (IOS) imaging has been used extensively to examine activity-related changes within the cerebral cortex. A significant technical challenge with IOS imaging is the presence of large noise, artefact components and periodic interference. Signal processing is therefore important in obtaining quality IOS imaging results. Several signal processing techniques have been deployed, however, the performance of these approaches for IOS imaging has never been directly compared. The current study aims to compare signal processing techniques that can be used when quantifying stimuli-response IOS imaging data. Data were gathered from the somatosensory cortex of mice following piezoelectric stimulation of the hindlimb. The effectiveness of each technique to remove noise and extract the IOS signal was compared for both spatial and temporal responses. Careful analysis of the advantages and disadvantages of each method were carried out to inform the choice of signal processing for IOS imaging. We conclude that spatial Gaussian filtering is the most effective choices for improving the spatial IOS response, whilst temporal low pass and bandpass filtering produce the best results for producing temporal responses when periodic stimuli are an option. Global signal regression and truncated difference also work well and do not require periodic stimuli.
Sexual and Vertical Transmission of Zika Virus in anti-interferon receptor-treated Rag1-deficient mice
Authors: Winkler Clayton W. , Woods Tyson A. , Rosenke Rebecca , Scott Dana P. , Best Sonja M. , Peterson Karin E.
Published: July 2017

Although Zika virus (ZIKV) is primarily transmitted to humans by the Aedes aegypti mosquito, human-to-human transmission has also been observed from males-to-females as well as mother-to-offspring. In the current study, we studied both sexual transmission (STx) and vertical transmission (VTx) of ZIKV using anti-IFNAR1-treatment of Rag1−/− (AIR) mice. These mice have suppressed type I IFN responses and lack adaptive immune responses, leading to a prolonged infection prior to clinical disease. STx of ZIKV from infected AIR males to naive Ifnar1−/− females was observed with greater than 50% incidence, with infection observed in the vaginal tract at early time points. In the case of a resulting pregnancy, virus was also found in the uterus and placental tissue. In additional studies, VTx of virus was observed in AIR female mice. Specifically, peripheral ZIKV infection of pregnant AIR females resulted in detectable virus in brain and/or lymph nodes of fetuses and/or pups. VTx of ZIKV was stochastic, in that not all fetuses/pups within the same dam had detectable virus and infection was not associated with breakdown of maternal/fetal placental barrier. This provides a new model to study the barriers to STx and VTx of ZIKV and the immune responses essential to preventing transmission.
Dynamics of the Global Wheat Trade Network and Resilience to Shocks
Authors: Fair Kathyrn R. , Bauch Chris T. , Anand Madhur
Published: July 2017

Agri-food trade networks are increasingly vital to human well-being in a globalising world. Models can help us gain insights into trade network dynamics and predict how they might respond to future disturbances such as extreme weather events. Here we develop a preferential attachment (PA) network model of the global wheat trade network. We find that the PA model can replicate the time evolution of crucial wheat trade network metrics from 1986 to 2011. We use the calibrated PA model to predict the response of wheat trade network metrics to shocks of differing length and severity, including both attacks (outward edge removal on high degree nodes) and errors (outward edge removal on randomly selected nodes). We predict that the network will become less vulnerable to attacks but will continue to exhibit low resilience until 2050. Even short-term shocks strongly increase link diversity and cause long-term structural changes that influence the network’s response to subsequent shocks. Attacks have a greater impact than errors. However, with repeated attacks, each attack has a lesser impact than the previous attack. We conclude that dynamic models of multi-annual, commodity-specific networks should be further developed to gain insight into possible futures of global agri-food trade networks.
Occurrence and expression of novel methyl-coenzyme M reductase gene (mcrA) variants in hot spring sediments
Authors: McKay Luke J. , Hatzenpichler Roland , Inskeep William P. , Fields Matthew W.
Published: July 2017

Recent discoveries have shown that the marker gene for anaerobic methane cycling (mcrA) is more widespread in the Archaea than previously thought. However, it remains unclear whether novel mcrA genes associated with the Bathyarchaeota and Verstraetearchaeota are distributed across diverse environments. We examined two geochemically divergent but putatively methanogenic regions of Yellowstone National Park to investigate whether deeply-rooted archaea possess and express novel mcrA genes in situ. Small-subunit (SSU) rRNA gene analyses indicated that Bathyarchaeota were predominant in seven of ten sediment layers, while the Verstraetearchaeota and Euryarchaeota occurred in lower relative abundance. Targeted amplification of novel mcrA genes suggested that diverse taxa contribute to alkane cycling in geothermal environments. Two deeply-branching mcrA clades related to Bathyarchaeota were identified, while highly abundant verstraetearchaeotal mcrA sequences were also recovered. In addition, detection of SSU rRNA and mcrA transcripts from one hot spring suggested that predominant Bathyarchaeota were also active, and that methane cycling genes are expressed by the Euryarchaeota, Verstraetearchaeota, and an unknown lineage basal to the Bathyarchaeota. These findings greatly expand the diversity of the key marker gene for anaerobic alkane cycling and outline the need for greater understanding of the functional capacity and phylogenetic affiliation of novel mcrA variants.
A selective electrochemical sensor for caffeic acid and photocatalyst for metronidazole drug pollutant - A dual role by rod-like SrV2O6
Authors: Karthik R. , Kumar J. Vinoth , Chen Shen-Ming , Kumar P. Senthil , Selvam V. , Muthuraj V.
Published: July 2017

In the present study, well-defined one-dimensional (1D) rod-like strontium vanadate (SrV2O6) was prepared by simple hydrothermal method without using any other surfactants/templates. The successful formation of rod-like SrV2O6was confirmed by various analytical and spectroscopic techniques. Interestingly, for the first time the dual role of as-prepared rod-like SrV2O6were employed as an electrochemical sensor for the detection of caffeic acid (CA) as well as visible light active photocatalyst for the degradation of metronidazole (MNZ) antibiotic drug. As an electrochemical sensor, the SrV2O6modified glassy carbon electrode (GCE) demonstrated a superior electrocatalytic activity for the detection of CA by chronoamperometry and cyclic voltammetry (CVs). In addition, the electrochemical sensor exhibited a good current response for CA with excellent selectivity, wide linear response range, lower detection limit and sensitivity of 0.01–207 µM, 4 nM and 2.064 μA μM−1cm−2, respectively. On the other hand, as-synthesized rod-like SrV2O6showed highly efficient and versatile photocatalytic performances for the degradation of MNZ, which degrades above 98% of MNZ solution under visible light irradiation within 60 min. The obtained results evidenced that the improvement of rod-like SrV2O6might be a resourceful electrocatalyst and photocatalyst material in the probable applications of environmental and biomedical applications.
Measurement of the emission spectrum of a semiconductor laser using laser-feedback interferometry
Authors: Keeley James , Freeman Joshua , Bertling Karl , Lim Yah Leng , Mohandas Reshma A. , Taimre Thomas , Li Lianhe H. , Indjin Dragan , Rakić Aleksandar D. , Linfield Edmund H. , Davies A. Giles , Dean Paul
Published: July 2017

The effects of optical feedback (OF) in lasers have been observed since the early days of laser development. While OF can result in undesirable and unpredictable operation in laser systems, it can also cause measurable perturbations to the operating parameters, which can be harnessed for metrological purposes. In this work we exploit this ‘self-mixing’ effect to infer the emission spectrum of a semiconductor laser using a laser-feedback interferometer, in which the terminal voltage of the laser is used to coherently sample the reinjected field. We demonstrate this approach using a terahertz frequency quantum cascade laser operating in both single- and multiple-longitudinal mode regimes, and are able to resolve spectral features not reliably resolved using traditional Fourier transform spectroscopy. We also investigate quantitatively the frequency perturbation of individual laser modes under OF, and find excellent agreement with predictions of the excess phase equation central to the theory of lasers under OF.