bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of Caspase-3 on HIV-1 Latency in a 3.01 Cells
Authors:   Lab of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, USA, X Wang , H Huang ,   Lab of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, USA, S Biswas ,   Lab of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, USA, J Zhao ,   Lab of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, USA, K Devadas ,   Lab of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, USA, I Hewlett ,   Lab of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, USA
Published: February 2023

Latent infection is a major barrier for cure of HIV-1/AIDS. HIV-1 is capable of establishing latency and the components of the apoptotic pathways may affect viral latency. However, it is not well-known how anti/pro-apoptotic components modulate HIV-1 replication and latency. Using the susceptible A3.01 cell line, we investigated some long-term effects of caspase-3 activities on HIV-1 DNA levels using a sensitive real-time PCR assay. Here we report that viral DNA levels increased upon treatment with caspase-3 inhibitor, Z-DEVD and decreased with caspase-3 activator, PAC1. We also simultaneously measured viral RNA from supernatants of these cell cultures and found that the degree of HIV-1 latency is inversely proportional to levels of viral replication. Furthermore, we demonstrated that inhibition of caspase-3 activities promoted viral latency and inhibited viral replication in several ways, which may include: 1) inhibition of viral RNA un coating with increased Trim5a expression; 2) deleterious mutations in the viral genome with increased APOBEC3G; 3) transcriptional interference with decreased levels of the host factors, NF-κB p65, Ap-1, Sp-1, NFAT, STAT1/3/5, IRF3/7, inactivated YB-1 and MAPK, Erk1/2 and p38, and inhibition of full-length of HIV-1 mRNA and P-TEF b signaling; 4) epigenetic silencing with decreased PCAF; 5) blocking trafficking of the components of viral particle and budding with decreased Tag101 and Alix. These data suggest that HIV-1 infection can employ or even manipulate the cellular apoptotic status to favor viral survival and escape monitoring and destruction by the host immune system.
Opportunistic Infections in People Living with Human Immunodeficiency Virus Initiating Antiretroviral Therapy in Kinshasa, Democratic Republic of Congo
Authors:   HIV/AIDS Focus, Research Group, Kinshasa, Democratic Republic of Congo, Ntumba Thérèse Kaseka , Bongenya Berry Ikolango ,   HIV/AIDS Focus, Research Group, Kinshasa, Democratic Republic of Congo, Losenga Lambert Omombo ,   HIV/AIDS Focus, Research Group, Kinshasa, Democratic Republic of Congo, Booto Grace Ipaya ,   HIV/AIDS Focus, Research Group, Kinshasa, Democratic Republic of Congo, Dikati Noëlla Makela ,   HIV/AIDS Focus, Research Group, Kinshasa, Democratic Republic of Congo, Dembo Rosalie Djamba ,   HIV/AIDS Focus, Research Group, Kinshasa, Democratic Republic of Congo, Selenge Stéphanie Mauwa ,   HIV/AIDS Focus, Research Group, Kinshasa, Democratic Republic of Congo, Nonga Jocelyn Ewuti ,   Department of Neurology, Faculty of Medicine, University of Kinshasa, Kinshasa, Democratic Republic of Congo, Kabamba Candide About ,   Department of Neurology, Faculty of Medicine, University of Kinshasa, Kinshasa, Democratic Republic of Congo, Kabengele Benoit Obel ,   Department of Internal Medicine, University Clinic, Faculty of Medicine, University of Kinshasa, Democratic Republic of Congo, Sombo Marie-Thérèse Ayanne Safi ,   Department of Neurology, Faculty of Medicine, University of Kinshasa, Kinshasa, Democratic Republic of Congo, Bumoko Guy Makila Mabe ,   Department of Neurology, Faculty of Medicine, University of Kinshasa, Kinshasa, Democratic Republic of Congo, Kamangu Erick Ntambwe ,   HIV/AIDS Focus, Research Group, Kinshasa, Democratic Republic of Congo
Published: February 2023

Background: Opportunistic infections, which are still a major problem in the care of People Living with HIV (PLHIV), occur in situations of immunosuppression. Objective: The objective of this study was to determine the profile of Opportunistic Infections in People Living with HIV starting Antiretroviral Treatment (ART) in Kinshasa during the Dolutegravir era. Methods: The present study is a descriptive cross-sectional study to determine the profile of OIs among PLHIV starting ART in Outpatient Treatment Centers (OTC) in Kinshasa. Sixteen OTCs had been included in the study. The patient inclusion period in the study was from October 04, 2021 to February 15, 2022. The population of the present study was patients over the age of 18 at inclusion, infected with HIV-1 and starting ART in a selected OTC. Results: 119 patients were included in this study respecting the inclusion criteria. 56.3% of patients included are women. The mean age on D0 is 39.87 ± 12.36 years. The most represented age group is that of 36 to 45 years with 37 patients (31.9%). The Opportunistic Infections most found in these PLHIV are: Malaria with 54 cases (45.4%), Tuberculosis (29.4%) and Cutaneous pruritus (23.5%). Conclusion: In this cohort of patients starting ARV treatment in Kinshasa, the most common opportunistic infections are Malaria, Tuberculosis and Cutaneous Pruritus.
A Mouse Model of Yellow Fever Virus Infection for Study of Pathogenesis and Development of Vaccines and Therapeutics
Authors:   Pôle de Virologie, Institut Pasteur de Dakar, Sénégal, M Dia , Y Dieye ,   Pôle de Microbiologie, Institut Pasteur de Dakar, Sénégal, CM Nguer ,   Groupe de Recherche Biotechnologies Appliquées & Bioprocédés environnementaux, École Supérieure Polytechnique, Université Cheikh Anta Diop, Dakar, Sénégal, AP Bédékélabou ,   Pôle de Virologie, Institut Pasteur de Dakar, Sénégal, CSB Boye ,   Centre de Reference IST/VIH,Centre Hospitalier Universitaire Aristide le Dantec, Dakar, Sénégal, O Faye ,   Pôle de Virologie, Institut Pasteur de Dakar, Sénégal, C Fall ,   Pôle de Microbiologie, Institut Pasteur de Dakar, Sénégal
Published: February 2023

Yellow Fever (YF) is a mosquito-borne viral disease that is endemic in several African and South American countries. YF Virus (YFV) causes subclinical infections with mild and non-specific symptoms, to severe, potentially lethal illness. Despite the existence of efficient vaccines, epidemics continue to occur, mostly in Africa. One major drawback of the available YF vaccines is their method of preparation that is fastidious and have limits to produce high volumes of doses needed to respond to recurring epidemics. The best available animal models for YFV are Non-Human Primates (NHP) in which it causes a disease similar to human infection. However, the cost of NHP studies is a limit to preclinical studies. There are a few mouse models of YF. However, these models consist of genetically deficient rodents that are not the best for evaluating new vaccines or therapies. We have developed a mouse model of YFV infection based on the Swiss Webster out bred strain. We have tested several epidemic isolates and identified two strains that, when administrated by the intraperitoneal route, caused an acute infection leading to death. Interestingly, these YFV strains are lethal only when prepared from mouse brain and not when cultured on cell lines. We used this model to test the efficacy of the 17D YFV vaccine strain in protecting mice against lethal challenge showing that the model can be used to evaluate new YF vaccines and therapies.
A Double-Walled Tetrahedron with AgI4 Vertices Binds Different Guests in Distinct Sites
Authors: Clark Samuel , Heard Andrew , McTernan Charlie , Ronson Tanya , Rossi Barbara , Rozhin Petr , Marchesan Silvia , Nitschke Jonathan
Published: February 2023

A double-walled tetrahedral metal-organic cage assembled in solution from silver(I), 2-formyl-1,8-naphthyridine, halide, and a threefold-symmetric triamine. The AgI4X clusters at its vertices bring together six naphthyridine-imine moieties, leading to a structure in which eight tritopic ligands bridge four clusters in an (AgI4X)4L8 arrangement. Four ligands form an inner set of tetrahedron walls that are surrounded by the outer four. The cage has significant interior volume, and was observed to bind anionic guests. The structure also possesses external binding clefts, located at the edges of the cage, which bound small aromatic guests. Halide ions bound to the silver clusters were observed to exchange in a well-defined hierarchy, allowing modulation of the cavity volume. The principles uncovered here may allow for increasingly more sophisticated cages with silver- cluster vertex architectures, with post-assembly tuning of the interior cavity volume enabling targeted binding behavior.
Precise, orthogonal remote-control of cell-free systems using photocaged nucleic acids
Authors: Mazzotti Giacomo , Hartmann Denis , Booth Michael
Published: February 2023

Cell-free expression of a gene to protein has become a vital tool in nanotechnology and synthetic biology. Remote-control of cell-free systems with multiple, orthogonal wavelengths of light would enable precise, non-invasive modulation, opening many new applications in biology and medicine. While there has been success in developing ON switches, the development of OFF switches has been lacking. Here, we have developed orthogonally light-controlled cell-free expression OFF switches by attaching nitrobenzyl and coumarin photocages to antisense oligonucleotides. These light-controlled OFF switches can be made from commercially available oligonucleotides and show a tight control of cell-free expression. Using this technology, we have demonstrated orthogonal degradation of two different mRNAs, depending on the wavelength used. By combining with our previously generated blue light-activated DNA template ON switch, we were able to start transcription with one wavelength of light and then halt the translation of the corresponding mRNA to protein with a different wavelength, at multiple timepoints. This precise, orthogonal ON and OFF remote-control of cell-free expression will be an important tool for the future of cell-free biology, especially for use with biological logic gates and synthetic cells.
Plant mobile domain proteins ensure Microrchidia 1 expression to fulfill transposon silencing
Authors: Jarry Lucas , Descombin Julie , Nicolau Melody , Dussutour Ange , Picault Nathalie , Moissiard Guillaume
Published: February 2023

Silencing of transposable elements (TEs) is an essential process to maintain genomic integrity within the cell. InArabidopsis, together with canonical epigenetic pathways such as DNA methylation and modifications of histone tails, the plant mobile domain (PMD) proteins MAINTENANCE OF MERISTEMS (MAIN) and MAIN-LIKE 1 (MAIL1) are involved in TE silencing. In addition, the MICRORCHIDIA (MORC) ATPases, including MORC1, are important cellular factors repressing TEs. Here, we describe the genetic interaction and connection between the PMD and MORC pathways by showing thatMORC1expression is impaired inmainandmail1mutants. Transcriptomic analyses of higher order mutant plants combiningpmdandmorc1mutations, andpmdmutants in whichMORC1expression is restored, show that the silencing defects of a subset of TEs inpmdmutants are most likely the consequence ofMORC1down-regulation. Besides, a significant fraction of up-regulated TEs inpmdmutants are not targeted by the MORC1 pathway.
NILAI BATAS KEWAJARAN HARGA UNTUK TENDER PEKERJAAN KONTRUKSI KUALIFIKASI USAHA KECIL (STUDI KASUS PEMBANGUNAN JEMBATAN GANTUNG SUNGAI PISANG)
Authors: Rusli Andi Mulya
Published: February 2023

Abstract

 

Presidential Regulation of the Republic of Indonesia Number 12 of 2021 contains an increase in the ceiling limit for construction work for small businesses to fifteen billion rupiah. Meanwhile, bid prices with a value of less than 80% of the Owner Estimate (OE) continue to increase every year. Referring to the Regulations of the Government Goods/Services Procurement Policy Agency (LKPP), price fairness evaluation is only carried out for bids less than 80% of OE. This is interesting to study. The Sungai Pisang Suspension Bridge Construction Work, with an offer of 84.97% to the HPS, was used as the research sample. Data show that the tender winner resigned before the expiration of his bid guarantee period due to price increases which were influenced by global economic conditions. Based on an analysis of the main payment item (MPU), 3 items of work were found with bids of less than 80% of the OE, namely: (1) supply of steel piles, amounting to 76.81% of the OE, (2) supply of structural concrete Fc'25 MPa, of 72.34% of the OE, and (3) installation of steel frame bridges of 62.60% of the OE. This study shows that a bid of 84.97% of OE is declared unreasonable. In order to avoid similar risks, the reasonable price limit for small businesses in the Presidential Regulation derivative needs to be evaluated in a more comprehensive manner.

 

Keywords: small business; bid price limit; bid price; price fairness; main payment item

 

Abstrak

 

Peraturan Presiden Republik Indonesia Nomor 12 Tahun 2021 memuat kenaikan batasan pagu untuk pekerjaan kontruksi bagi usaha kecil menjadi lima belas milyar rupiah. Sementara itu, harga penawaran dengan nilai kurang dari 80% Harga Perkiraan Sendiri (HPS) terus meningkat setiap tahunnya. Mengacu Peraturan Lembaga Kebijakan Pengadaan Barang/Jasa Pemerintah (LKPP), evaluasi kewajaran harga hanya dilakukan untuk penawaran kurang dari 80% HPS. Hal ini menarik untuk dikaji. Pekerjaan Pembangunan Jembatan Gantung Sungai Pisang, dengan penawaran 84,97% terhadap HPS, digunakan sebagai sampel penelitian. Fakta menunjukkan bahwa pemenang tender mengundurkan diri sebelum habis masa jaminan penawarannya akibat kenaikan harga yang dipengaruh oleh kondisi ekonomi global. Berdasarkan analisis terhadap mata pembayaran utama (MPU), ditemukan 3 item pekerjaan dengan penawarannya kurang dari 80% HPS, yaitu: (1) penyediaan tiang pancang baja, sebesar 76,81% HPS, (2) penyediaan beton struktur Fc’25 MPa, sebesar 72,34% terhadap HPS, dan (3) pemasangan jembatan rangka baja sebesaar 62,60% HPS. Studi ini menunjukkan bahwa penawaran sebesar 84,97% HPS dinyatakan tidak wajar. Untuk menghindari risiko serupa, batas kewajaran harga untuk usaha kecil pada turunan Peraturan Presiden tersebut perlu dipertimbangkan lagi secara lebih komprehensif.

 

Kata-kata kunci: usaha kecil; batasan pagu; harga penawaran; kewajaran harga; mata pembayaran utama
ANALISIS PENUNJANG UNTUK PERANCANGAN JALAN DENGAN PERKERASAN BERASPAL SEBAGAI INFRASTRUKTUR JALAN YANG ANDAL, MANDIRI, DAN BERKELANJUTAN
Authors: Ali Muhammad Fakhri , Ramadianti Khansa
Published: February 2023

Abstract

 

The high rate of road construction in Indonesia must be accompanied by an increase in road quality, so that roads are more reliable. Many factors affect road reliability, such as heavier truck loads requiring trucks with more axles and the v/c ratio of roads which affect the ability of asphalt pavements to accept loads. In traffic congestions, the strain that occurs in asphalt pavement structures can increase up to 370 millimicrons, or about 3 times greater than the strain that occurs in normal conditions. Meanwhile, to increase the independence of road construction in Indonesia, the use of domestic products in the form of Buton natural asphalt (Asbuton) needs to be continuously developed. In its use, Asbuton with a maximum content of 5.5% in the mixture has produced an asphalt mixture that meets existing specifications. The availability of Asbuton in Indonesia, which reaches around 600 thousand tons, must be utilized as best as possible. The use of concrete waste can be carried out, using a maximum asphalt content of 6.5%, with all aggregates being substituted with concrete waste. While the use of substitute materials in the form of plastic can only replace aggregates on asphalt pavements as much as 6.15%.

 

Keywords: road construction; road quality; pavement strain; buton natural asphalt

 

 

Abstrak

 

Tingginya pembangunan jalan di Indonesia harus disertai dengan peningkatan kualitas jalan, sehingga jalan lebih andal. Banyak faktor yang berpengaruh pada keandalan jalan, seperti muatan truk yang lebih berat memerlukan truk dengan gandar yang lebih banyak serta v/c ratio jalan yang memengaruhi kemampuan perkerasan beraspal jalan dalam menerima beban. Pada keaadan lalu lintas macet, regangan yang terjadi pada struktur perkerasan beraspal dapat meningkat sampa dengan 370 milimikron, atau sekitar 3 kali lipat lebih besar daripada regangan yang terjadi pada keadaan normal. Sementara itu, untuk meningkatkan kemandirian pembangunan jalan di Indonesia, pemakaian produk dalam negeri berupa aspal alam Buton (Asbuton) perlu terus dikembangkan. Dalam penggunaannya, Asbuton dengan kadar maksimum 5,5% dalam campuran telah menghasilkan campuran beraspal yang memenuhi spesifikasi yang ada. Ketersedian Asbuton di Indonesia, yang mencapai sekitar 600 ribu ton, harus dimanfaatkan sebaik mungkin. Penggunaan limbah beton dapat dilakukan, dengan menggunakan kadar aspal maksimum sebesar 6,5%, dengan semua aggregat dapat disubstitusi dengan limbah beton. Sementara penggunaan material substitusi berupa plastik hanya dapat menggantikan aggregat pada pekerasan beraspal sebanyak 6,15%.

 

Kata-kata kunci: pembangunan jalan; kualitas jalan; regangan pada perkerasan; aspal alam buton
Percepcion de las competencias pedagogicas de un docente universitario del area de enfermería
Authors: Lopez Escalona Deivis eduardo , Hernández Romero Gladys
Published: February 2023

El presente estudio tuvo como propósito general develar la percepción de las competencias pedagógicas que posee el docente de Enfermería en el Centro de Capacitación Continua en Primeros Auxilios, Atención Prehospitalaria y Enfermería del cantón Otavalo, provincia Imbabura, Ecuador. Este trabajo se ubica en la línea de investigación gerencia educativa, en el cual son fundamentadas las competencias pedagógicas del docente universitario, el de enfoque de la investigación es de tipo cualitativo y el método empleado para abordar el estudio fue el fenomenológico-hermenéutico. Para recolectar los datos, la técnica e instrumento empleado fue la entrevista a profundidad. Por consiguiente, se seleccionaron tres informantes claves que aportaron su experiencia y punto de vista de las competencias pedagógicas; igualmente, la técnica para el análisis fue la triangulación, esta permitió categorizar y estructurar mediante matrices los hallazgos referidos al estudio con el fin de interrelacionar los principios epistemológicos, axiológicos y metodológicos que fundamentan las competencias pedagógicas. Los hallazgos significativos dilucidaron el hecho de que efectivamente las competencias pedagógicas del docente universitario dependen invariablemente del aporte personal del individuo, pero también del entorno en el que desarrolla sus funciones. Se menciona que, hablar de competencias docentes, es involucrar conceptos y aportes que la educación tiene para fortalecer los procesos de enseñanza y aprendizaje.
Innovación educativa en la TV. Estudio de caso: The Handmaid´s Tale
Authors: Urcid Puga Rodrigo
Published: February 2023

El siguiente artículo apuesta por vincular a la educación con el contenido audiovisual y tiene como propósito proponer que, a partir del análisis a una serie de televisión, se puede fomentar el aprendizaje crítico y analítico de diversos temas sociales. La metodología empleada para la investigación fue cualitativa y se apoya en el análisis de contenido y del discurso. Este estudio se centra en el programa: The Handmaid´s Tale, esto con el afán de tener un producto audiovisual con el cual se pueda hacer la correlación antes señalada. Los resultados muestran que el contenido de esta serie ayuda al proceso de aprendizaje, ya que genera una visión más crítica sobre diversos aspectos sociales y culturales; además, a través de este tipo de enseñanza, se promueve el aula invertida.
Pengaruh Permainan Tradisional Gobag Sodor Terhadap Minat Belajar Siswa se-Kecamatan Lengkong Tahun Pelajaran 2020/2021
Authors: Nasta'in Tomi , Nurkholis Mohammad , Allsabah M. Akbar Husein
Published: February 2023

Latar Belakang: Latar belakang penelitian ini adalah pelestarian permainan tradisional yang banyak dimainkan di lingkup sekolah dasar membuat permainan ini sangat disukai dan menjadikan permainan gobak sodor dalam peningkatan minat belajar siswa sekolah dasar. Tujuan penelitian ini untuk mengetahui pengaruh permainan gobag sodor terhadap minat belajar siswa se Kec. Lengkong tahun pelajaran 2020/2021.Metode: Penelitian ini menggunakan metode quasi experimental, dengan One Group Pretest Posttest Design.Hasil: Hasil penelitian menunjukkan Terdapat pengaruh permainan tradisional gobag sodor terhadap minat belajar. Hal ini ditunjukkan dari hasil analisis uji-t diperoleh thitung = 27,838 dengan ttabel tingkat signifikan 5% df =70 sebesar 1,994. Jadi thitung > ttabel dengan sig. 0,000 < 0,05, maka Ha diterima dan H0 ditolak.Kesimpulan: Kesimpulan dalam penelitian ini yaitu terdapat pengaruh yang signifikan pada permainan tradisional gobag sodor terhadap minat belajar siswa Se Kec. Lengkong tahun pelajaran 2020/2021.
Aksiologi Kepemimpinan dalam Outbound di Kabupaten Tulungagung
Authors: Rudianto Diky , Pramono Made , Fithroni Hijrin , Purbodjati Purbodjati
Published: February 2023

Latar Belakang: Pemimpin yang baik ialah pemimpin yang memiliki kemampuan untuk memberi pengaruh dan menggerakkan anggotanya untuk bekerja sama dengan baik. Pola kepemimpinan dan juga keputusan-keputusan dari seorang pemimpin tidak hanya mempengaruhi capaian dari organisasi namun juga memberi pengaruh pada perilaku anggotanya. Penelitian ini bertujuan mengidentifikasi nilai-nilai kepemimpinan pada pelatihan kepemimpinan dan outbound di Kabupaten Tulungagung.Metode: Penelitian ini memakai jenis penelitian kualitatif dengan analisis deskriptif kualitatif yang pemilihan sampelnya memakai teknik sampling jenuh. Sampel yang digunakan ialah organisasi kepemudaan karang taruna kecamatan se-Kabupaten Tulungagung yang berjumlah 19 kecamatan se-Kabupaten Tulungagung. Teknik yang digunakan untuk mengidentifikasi nilai-nilai kepemimpinan pada pelatihan kepemimpinan dan outbound di Kabupaten Tulungagung yaitu reduksi data, penyajian data, dan penarikan kesimpulan.Hasil: Dalam penelitian ini terdapat domain tertinggi yakni; domain objektif responden yang memilih œsetuju sebesar 17 responden (81%), serta domain keterampilan sosial yang memilih œsetuju sebesar 17 responden (81%), dapat diartikan bahwa karang taruna pada setiap kecamatan dapat memberikan alasan yang rasional dalam setiap keputusan dan dapat diartikan bahwa karang taruna dapat menerima kritik dan saran dari anggota lain.Kesimpulan: Dapat disimpulkan bahwa nilai nilai yang terdapat pada domain mempunyai tujuan agar mengetahui gambaran serta mengidentifikasi dari nilai nilai kepemimpinan yang terdapat pada pelatihan kepemimpinan outbound di Kabupaten Tulungagung.
Identifikasi dan Analisis Pengetahuan Mahasiswa Ilmu Keolahragaan Angkatan 2019 Terhadap Olahraga Tradisional Indonesia
Authors: Kusuma Ferry , Sudijandoko Andun
Published: February 2023

Latar Belakang: Tujuan dari penelitian ini untuk mengetahui pengetahuan mahasiswa ilmu keolahragaan angkatan 2019 terhadap olahraga tradisional Indonesia.

Metode: Jenis penelitian ini menggunakan deskriptif kuantitatif, dengan menggunakan metode survei dan cara pengambilan datanya peneliti menggunakan media google form untuk membantu mahasiswa dalam pengisian kuisoner.

Hasil : Pengetahuan mahasiswa terhadap olahraga tradisional Indonesia berada pada kategori tinggi.

Kesimpulan: Berdasarkan hasil dari penelitian yang telah dilakukan dan hasil pembahasan di atas, maka dapat dikedepankan kesimpulan sebagai berikut:  Mahasiswa Ilmu Keolahragaan angkatan 2019 terhadap olahraga tradisional Indonesia dalam kategori pengetahuan persebarannya:  sangat tinggi sebesar 3%, kategori tinggi sebesar 38%, kategori sedang sebesar 32%, kategori rendah sebesar 15%, kategori sangat rendah sebesar 12%.  Mahasiswa Ilmu Keolahragaan angkatan 2019 . Pada penelitian ini dapat di simpulkan pula, bahwa pemahamannya terhadap olahraga tradisional Indonesia berada pada kategori yang tinggi dengan prosentase 38%. Dan sangat tinggi sebesar 3%.
La construcción sonora en "Estorvo" (1991) de Chico Buarque
Authors: Morales Hernán
Published: February 2023

A partir de una aproximación a la poética de Chico Buarque desde una de sus novelas, Estorvo (1991), nos proponemos indagar aspectos que ubicarían los relatos de este escritor músico entre lo sonoro y lo verbal. Una narrativa donde rasgos convencionales entran en crisis por un descentramiento que compromete el “encuentro” de lenguas, registros, discursos, figuraciones y sonoridades en el espacio de escenarios latinoamericanos. Dichos encuentros crearían como zona de contacto, un discurso híbrido, desplazado de patrones conocidos, de una sola gramática, entre otros, para configurar tensiones poco frecuentes en textos narrativos (Literatura/Música, palabra/sonido).
Lenguaje y eufonía, ejes vertebradores en "Los pasos perdidos" de Alejo Carpentier
Authors: Abellán Chuecos Isabel
Published: February 2023

Alejo Carpentier, además de autor, fue musicólogo. Esta cuestión propicia la preocupación por el lenguaje en la creación de sus obras, dotando a sus novelas y demás escritos de ese barroquismo tan característico en su estilo, buscando la eufonía y la máxima expresión. Se trata no solamente de una cuestión estilística sino también relacionada con una preocupación filológica. Además, en relación con sus estudios anteriormente mencionados, encontramos un aspecto enlazado con el lenguaje que no siempre es mostrado por los escritores: la preocupación por la acústica. Carpentier no podía obviar la cuestión auditiva, que se observará igualmente en la dotación a sus novelas de todo un universo sonoro en el que el lenguaje estará incluido. Podemos observar, así, la eufonía y el cuidado por el lenguaje al tiempo que el lenguaje como música. De este modo, podemos acceder al estudio del lenguaje en sí mismo y cómo este interactúa y confiere diversos caracteres en la obra.
Presentación
Authors: Gasillón María Lourdes , Abellán Chuecos Isabel
Published: February 2023

Palabras de presentación al Dossier "Encuentros artísticos: diálogos entre literatura, imagen y música", coordinado por las Dras. Isabel Abellán y María Lourdes Gasillón.
Digital Government in Social Sciences Discipline: Mapping Pivotal Features and Proposed Theoretical Model
Authors: Hasanah Siti , Pratama Inka Nusamuda , Rahmat Al Fauzi , Kurniawan Cahyadi
Published: February 2023

The research aimed to describe the trend issues, identify the key features, and propose a theoretical model of digital government. A comprehensive search was used to find eligible articles in the Academic Scopus Database. Further, the quality of the study was assessed during the screening phase, where it met 115 journal-related articles on digital government within the social sciences discipline. Further, this literature was analyzed by NVivo 12 Plus via a hierarchy diagram, cluster analysis, word frequency analysis, and the VOSViwer tool to visualize the data via a network, overlay, and density analysis. The findings revealed a term network formed by digital government and trend issues, resulting in several growing concerns, such as e-government, open government, and technology adoption. Furthermore, key features were reported following proportional analysis, such as systems, development, services, models, information, public, policy, management, and networks. Another point is that a proposed theoretical model has been constructed and selected for future research.
Evaluation of serum anti-Müllerian hormone (AMH) and equine chorionic gonadotrophin (eCG) concentrations in pregnant mares in relation to foetal sex
Authors: Uçmak Melih , Turna Özge , Günay Uçmak Zeynep , Erzengin Asuman
Published: February 2023

The aim of this study was to investigate the foetal sex related difference and progression in maternal serum anti-Müllerian hormone (AMH) and equine chorionic gonadotrophin (eCG) concentrations during different points of time in pregnant Arabian mares. The study groups formed by 12 healthy male offspring- and 12 healthy female offspring-foaling mares, designated as group MFM and group FFM, respectively. Peripheral blood samples were collected on the day of natural mating and then monthly until the 6thmonth (mo) of gestation. Serum AMH was measured in all serum samples; eCG was measured in samples collected from 2 to 5 months Of gestation. Serum AMH concentrations of group FFM at mo 4 and mo 5 (3.89 ± 0.49 ng/ml; 2.89 ± 0.32 ng/ml), were significantly higher than in group MFM (2.11 ± 0.46 ng/ml; 1.87 ± 0.32 ng/ml), (P< 0.05). The mo of gestation (mo 1–6) had no effect on serum AMH concentrations of either group MMF or FFM (P> 0.05). Serum eCG concentrations of group FFM at mo 2 (359.73 ± 41.51 mIU/ml), were significantly higher than in group MFM (255 ± 21.18 mIU/ml) (P< 0.05). Group-time interaction for eCG concentrations at mo 2–4 was non-significant (P> 0.05). Concentrations of serum AMH showed no relationship with corresponding eCG levels at mo 2–4 (P> 0.05). Individual variations in AMH and eCG concentrations and the inability to determine a cut-off point for determination of foetal sex make these hormones unlikely candidates for determining foetal sex in the mare.
RUSSIAN LITERARY LANDSCAPE. BETWEEN NATURE AND HISTORY
Authors:   HSE University, Bochkarev Andrey E.
Published: February 2023

The article deals with the specifics of a Russian literary landscape’s construction as a system of values organized in a particular way. It allows answering the question what is good and what is beauty in the life context relevant to a human being. In this regard, special attention is paid to various descriptions. They allow not only to describe and individualize the contemplated natural forms like meadows, fields, lakes and forests, but also to understand, realize and evaluate those familiar marks of the central Russia’s landscape in connection with some axiological concepts significant for a human being, such as God, life, freedom, liberty, art, happiness, or virtue, as a historically dynamic system of values. In that sense, a literary landscape is more than a recognizable image of a place; it is also a “focus of the world-like-history”.
“AND IT IS NECESSARY THAT THE OTHER GOES...”. BIBLE QUOTES AND THEIR SOURCES IN ALEXANDER BLOK’S WORKS
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Magomedova Dina M. ,   Russian State University for the Humanities
Published: February 2023

The article considers and describes the marks on the pages of the Bible, preserved in the home library of A. Blok. The greatest number of marginalia is found in the Pentateuch, Ecclesiastes, the Book of Wisdom of Solomon, the Gospel of John, the 1st Epistle of John, and the Revelation of John the Theologian. A number of quotations are reflected in Blok’s poems, dramas, and articles. The influence of the text of the Apocalypse is particularly evident in the early lyrics of 1901–1904, and then, in the period of “antithesis” (1905–1908), not only in poetry, but also in drama. The analysis of markings in the Gospel makes it clear that the Other, about whom Blok spoke in connection with the figure of Christ in the poem “The Twelve”, is the Holy Spirit, the Comforter. As a source of biblical reminiscences the author considers the text of the “Service of the Church of St. John”, created by D.S. Merezhkovsky and Z.N. Gippius and used by them in home services. Quotations from that source in Blok’s poems allow the author to question the extent of Blok’s knowledge with the practice preached by D.S. Merezhkovsky “The Church of the Third Testament”
PERCEPTION OF PERSONALITY AND WORK OF I.S. TURGENEV IN THE STORY “THE REVIVAL” BY J. BARNES
Authors:   Moscow State Linguistic University, Chernova Yulia V. , Nikolich Militsa ,   Moscow State Linguistic University
Published: February 2023

The article deals with an analysis of the image of I.S. Turgenev in the story “The Revival” by Julian Barnes. The aim of the work is to reveal the characteristics and the role of Turgenev’s image in the story “The Revival”. The chosen topic of the study is relevant due to the undying interest to the English writer‘s work in Russian literary studies. The personality and the work of Turgenev made an important impact on the Barnes’s wordview and his texts. In “The Revival” the author is focused on the artistic image of the Turgenev’s last love with the theatre actress Mariya Savina. Drawing on areal event from the life of Turgenev, Barnes creates his own perception of what was happening by using the literary techniques of fabulation, fragmentation and irony. British writer involves a reader into a specific game. A reader can hardly decide which facts are truth, about the Russian writer’s last love, when it is additionally complicated with the fragmentary images of what was happening between Turgenev and the actress, and illustrated by the letters of Russian writer filled in with frequent shifts between the episodes, showing the unreliability of the memory. The comprehension of the personality and the work of Russian writer is connected with the leading themes in the work of Barnes such as ageing, death and love.
THE IMAGE OF A MIRROR IN THE CONSTRUCTION OF NARCISSISTIC INTRIGUE IN CHINESE FEMALE PROSE. BASED ON THE WORKS OF LIN BAI
Authors:   Russian State University for the Humanities, Xinyu Jiang
Published: February 2023

The article presents the specifics in the development of modern Chinese female prose, presents views on the concept of “narcissism” and a person’s perception of himself in the mirror, describes the cultural meaning of the image of mirrors, considers the narration of the episode “appreciating one’s own beauty in front of the mirror” in the works of Lin Bai. The author interprets the role of the image of a mirror in female prose from a feminist point of view, gives a generalized description of the works of Lin Bai – to build a dialogue between women and the world
REPRESENTATION OF WORLD WAR II IMAGES IN POPULAR MUSIC. ALBUM “HEROES” OF HEAVY POWER METAL BAND “SABATON”
Authors:   HSE University, Medakin Sergey S.
Published: February 2023

The article identifies and analyzes the formation of images of the past in popular music on the example of the tracks from the album “Heroes” by the band “Sabaton”. The work studies the representations of the war images in popular music in the context of the original works of the musical group “Sabaton”, interviews of musicians, reviews of fans and critics, as well as videos of the popular science YouTube channel of the group. The author develops studies of representations of the military history images in the context of culture and the arts, using popular music, which is unpopular in research, but a large-scale and ubiquitous phenomenon. Through the involvement of audiovisual sources (video clips and performances at concerts), as well as interviews and video materials of the popular science channel, the author reveals an issue of narrativization and glorification of the historical past and its participants, the creation of completely new images and plots by the Swedish group in the context of representations of the past. The involvement and analysis of the works from the popular science channel “Sabaton History” allows to identify the background for the creation of songs by the Swedish band, to find out the opinions of musicians and a professional historian responsible for maintaining the channel. The example considered in the article demonstrates how popular music works with images of the past, and how the techniques of representation may vary depending on different cultural and linguistic contexts.
Execution of the federal budget: theoretical and practical aspects
Authors: Olisaeva Alisa , Carikaev Marat
Published: February 2023

The article is devoted to the study of the execution of the federal budget in the Russian Federation. The federal budget is the most important link in the country's budget system. The state, performing its fundamental functions, has an impact on socially important areas: healthcare, education, security, social policy and others, by channeling financial resources. The need to study the role of the state budget in the system of macroeconomic regulation is one of the most important aspects for making effective management decisions in the field of public administration. One of the areas of research of the federal budget of the Russian Federation is the analysis of the problems of execution of revenue and expenditure in the context of the implementation of macroeconomic policy in general. The article considers the dynamics of revenues to the federal budget, expenditures in the period 2019 - 2021. and for the period of 10 months of 2022. The factors influencing the change in federal budget revenues for the periods under review and their impact on the overall position of the volume of financial resources received by the budget are presented.
Demographic dependency on occupied territories
Authors: Bashirov Azat
Published: February 2023

The article defines the demographic load coefficients for rural areas of Tatarstan in the dynamics of 2016-2020. It was concluded that the demographic load coefficients do not correspond to the normative values. Forecasting the rural population through average growth shows an increase in load factors in the future. As a result of calculating the indicators of the demographic burden of the rural population of the Republic of Tatarstan, a conclusion was made about the high level of demographic old age. Due to the important tasks facing agricultural production, it is advisable to intensify the measures of demograic policy in rural areas.
Competitiveness of pig-breeding agro-industrial formations: the state and factors of its provision
Authors: Vitkalova Svetlana
Published: February 2023

The article deals with topical issues of pig breeding development on the example of high-tech agro-industrial formations. Using SWOT analysis, the strengths and weaknesses of economic entities in dynamically changing economic conditions were identified. Methodological approaches to ensuring the competitiveness of economic entities in the conditions of sanctions pressure and external threats are substantiated, predictive scenarios for increasing the competitiveness of high-tech pig farming agro-industrial formations are formulated and presented.
Protesta y resistencia. El arte contemporáneo en América Latina
Authors: Yokoigawa Miki , Cázares Cerda Gisela , Rojas Cuevas Maribel
Published: February 2023

Protesta y resistencia. El arte contemporáneo en América Latina nace en un contexto actual que nos vincula como estudiosos del arte desde el Área Académica de Artes Visuales del Instituto de Artes de la del área, principalmente el Cuerpo Académico Prácticas Visuales en el compartimos la inquietud de discutir el tema abiertamente con artistas, teóricos, investigadores nacionales e internacionales y estudiantes de artes.
Lesiones de mano más frecuentes en pianistas. Conocimiento y prevención
Authors: Santillán Varela Luis Antonio
Published: February 2023

La creciente necesidad de aumentar el rendimiento físico para poder competir en el mercado laboral de la música, el cual día con día logra niveles más altos de desempeño, exige a su vez a los ejecutantes mayor perfección, precisión, cantidad de repertorio y, con esto, un mayor número de conciertos y recitales. Esto ha llevado a muchos ejecutantes a tener que enfrentarse a una serie de problemas físicos, principalmente lesiones, causadas entre otras profesional, descuidos en aspectos técnicos básicos y falta de disciplina, lo cual conlleva a un estudio inconstante que pone en riesgo la salud, incluso teniendo una buena técnica en el instrumento.
Colonial Architecture Identification Of Uleebalang House In Aceh Through A Typological Approach (Case Study: Uleebalang House In Kec. Muara Batu, Gandapura And Peusangan)
Authors: Nurfajar Sarah , Dafrina Armelia , Novianty Yenny
Published: February 2023

Colonial architecture in Indonesia is a unique cultural form, this is not found anywhere else or in countries that were once occupied by the Dutch colonialists, because colonial architecture that developed in Indonesia contained a blend of cultures between the Dutch and Indonesians with a wide variety of building designs. Colonial architecture has the peculiarities of buildings that are able to adapt to local conditions and the local climate of each design. One of the colonial heritage architecture of the Netherlands is a house, especially in Aceh Province. These houses have the same concept, namely the concept of colonial architecture, but each building also has a different shape, such as different shapes in plans, facades and elements. Research on the Uleebalang house is important to do in order to maintain and maintain the historical value that once existed so that it can be preserved for the next generation. This study took three samples of houses, one of which is located in Kab. North Aceh (Uleebalang Krueng Mane's house) and two in Kab. Bireuen (Uleebalang Geurugok's house and Uleebalang Peusangan's house). This research concludes that there are many similarities between the Uleebalang Krueng Mane house and the Uleebalang Geurugok house, while the Uleebalang Peusangan house has differences in the floor plan and several other elements.
Description of Mercury Poison Clinical Symptoms in Workers and Communities Around the Small-Scale Gold Processing Area
Authors: Lensoni  , Adlim  , Kamil H , Karma T , Suhendrayatna
Published: February 2023

The traditional gold processing process in Paya Seumantok Village, Krueng Sabee District, Aceh Jaya Regency, Aceh Province, is carried out using the amalgamation method which still uses mercury in the process, so it poses a risk to the health of workers and the surrounding community. This study aims to obtain an overview of the clinical symptoms experienced by workers and the community around the gold processing area. This study uses qualitative research methods with the number of community respondents were 90 respondents, and the number of worker respondents were 10 workers. Based on the results, the common acute clinical symptoms experienced by the community were headache (48.6%), cough (39.6%), abdominal pain (37.8%), diarrhea (29.7%), and hip pain (25.2%). While the chronic clinical symptoms experienced by the majority of community respondents were headaches (47.7%), irritability (27.9%), insomnia (26.1%), muscle cramps (23.4%), and weight loss (20.7%). Moreover, the most common acute clinical symptoms experienced by workers were cough (8 respondents), pelvic pain, diarrhea, abdominal pain, vomiting, nausea, and headaches were experienced by 7 respondents respectively. While for chronic clinical symptoms, the majority of workers experienced headaches and insomnia (8 respondents), irritability (6 respondents), anxiety (6 respondents), muscle cramps (5 respondents), and tremors (4 respondents). Based on the result, it can be concluded that the clinical symptoms encountered by the community and workers in the gold processing area have not shown clinical signs that are quite dangerous.
Classification of Longan Types Using The Back-Propagation Neural Network Algorithm Based on Leaf Morphology With Shape Characteristics
Authors: Waail Al Wajieh Mohammad , Luqman Al-Farisi Bayuda
Published: February 2023

In Indonesia, longan fruit is abundantly accessible. The Longan fruit comes in a number of kinds, and they vary in terms of their morphology, including the characteristics of their leaves. The varieties of longan fruit are to be categorized in this study based on the shape of the leaves. The author uses the RGB color extraction function, the Grey Level Co-occurrence Matrix (GLCM), and the Shape feature to get data for each cultivar. The accuracy value is then processed using the Back-Propagation Neural Network (BPNN) technique to determine the accuracy value that will be used as a determinant of the categorization of the Longan leaf image. The eccentricity and metric parameters are key components of the method. The BPNN algorithm demonstrated its usefulness for categorizing various kinds of longan fruit leaves during testing by obtaining an accuracy of 70%.
Correlation Analysis of CBR and Sand Cone Values at the Sub Base of Simpang Tambue-Lhok Dagang Road at STA 1+050 to STA 6+450
Authors: Jufriadi  , A Fica. , Yanis M. , Radhi F. , S Era , Usrina N. , Sofyan
Published: February 2023

The rapid increase in traffic volume will lead to a lower level of road service, so that the traffic flow on the road becomes less smooth. To overcome this situation, efforts are needed, including repairing the pavement layer, one of which is the subbase layer. To determine the bearing capacity and degree of density of the subbase course, CBR field and Sand Cone tests are carried out. The purpose of this study was to analyze the relationship between the CBR value and the Sand Cone, the data were from the results of field and laboratory tests carried out by the executor, the CBR test results obtained were between 60.27% and 72.87% while the Sand Cone was between 59.88% and 62. .71% but after an average CBR and Sand Cone values become 62.48% and 60.44%. From the results of the Product Moment correlation test, a correlation value of -0.225 was obtained. This shows a negative relationship between CBR and Sand Cone values. Furthermore, from the results of the correlation coefficient significance test, it was obtained that t count = -0.730, this t count value is smaller than t table= 2.228 with degrees of freedom 12 -2 = 10 and an error rate of 5% for the 2-party test, so it can be concluded that Ho is accepted and H1 is rejected. This means that there is no significant correlation between CBR and Sand Cone values.
Rainfall Prediction Due to the Madden Julian Oscillation Factor at the Equator
Authors: Kusfirdianti Firda , Wiratmo Joko
Published: February 2023

In this research, the process of spectral analysis (Fast Fourier Transform) was carried out as a step to find out the phenomena that affect rainfall in the equatorial region which are represented by the cities of Kototabang, Pontianak, Gorontalo and Biak. This is followed by predicting rainfall due to the MJO phenomenon, which is obtained after performing a Bandpass Filter with a cut off of 30 and 90 days on rainfall time series data and the Inverse Fast Fourier Transform (IFFT), using the ARIMA method. The results showed that the study area under study generally had an equatorial rainfall pattern type. This rainfall is dominantly influenced by annual (monsoon) and semi-annual (ITCZ) phenomena. There is an intra-seasonal phenomenon (MJO) although it does not have a big impact on rainfall. ARIMA provides fairly good rainfall prediction results for a short period of time. Monthly rainfall predictions show values ​​below 90 mm, with the lowest predicted rainfall occurring in January in Gorontalo  (42.57 mm), and the highest in February in Biak  (86.83 mm).
Linezolid-Associated Black Tongue: A Rare Adverse Drug Reaction
Authors: Mishra Dr. Gyanshankar P.
Published: February 2023

Linezolid is an effective second-line anti-tuberculosis drug. However, the use of linezolid has been associated with rare adverse drug reactions (ADRs), one of which is the linezolid-associated black hairy tongue (BHT). This reaction is characterized by a black or dark brown discoloration of the tongue, which may be accompanied by a metallic or bitter taste. In this case report, we present a 19-year-old male patient who developed linezolid-associated black tongue while receiving linezolid as part of an all-oral, longer-course treatment regime for multidrug-resistant/rifampicin-resistant tuberculosis (MDR/RR-TB). The patient's BHT was only cosmetic and resolved upon discontinuation of linezolid. This case report aims to raise awareness of this rare ADR and the importance of close monitoring and potential withdrawal of linezolid to optimize treatment outcomes.