bluuebunny/crossref_metadata_2025 huggingface dataset:
Estratégia Long-Short, Neutra ao Mercado, e Index Tracking Baseadas em Portfólios Cointegrados
Authors: Caldeira João Frois , Portugal Marcelo Savino
Published: October 2019

Modelos de otimização de carteiras baseados na análise média-variância apresentam dificuldades para estimação das matrizes de covariância, o que leva a necessidade de métodos ad hoc para limitar ou suavizar as alocações eficientes recomendadas pelo modelo. Embora as carteiras obtidas por este método sejam eficientes, não é assegurado que o tracking error seja estacionário, podendo a carteira se distanciar do benchmark, exigindo frequentes recomposições. Neste artigo empregamos a metodologia de cointegração para otimização de carteiras no âmbito de duas estratégias: index tracking e estratégia long-short. A estabilidade das carteiras otimizadas através da cointegração em diferentes cenários de mercado, baixos custos com recomposição da carteira, níveis de retorno e volatilidade superiores aos benchmarks, mostram que a metodologia é uma ferramenta eficiente e capaz de gerar resultados robustos, se caracterizando como uma atraente ferramenta para a gestão quantitativa de recursos.
Determinantes da Estabilização de Preços em Ofertas Públicas Iniciais de Ações
Authors: Carvalho Antonio Gledson de , Pinheiro Douglas Beserra
Published: October 2019

O processo clássico de estabilização de preços em IPOs consiste na venda de um lote suplementar de ações (sobrealocação) e eventualmente recompra das mesmas (aftermarket short covering ou ASC) para evitar queda acentuada ou alta volatilidade do preço. Este artigo provê uma descrição da atividade de estabilização no Brasil e investiga seus determinantes em três aspectos: o exercício da opção de sobrealocação, a ocorrência da estabilização (ASC) e a intensidade da mesma. Os nossos resultados indicam que a estabilização é uma atividade importante em IPOs. A intensidade da estabilização no Brasil é semelhante àquela dos EUA. Os três diferentes aspectos da estabilização apresentam determinantes distintos: o exercício da opção de sobrealocação é determinada exclusivamente pelas condições de demanda; os IPOs estabilizados são aqueles com maior risco, com menor demanda e que são conduzidos por underwriters de melhor reputação e a intensidade da estabilização depende positivamente do risco e da demanda. Nenhum dos modelos teóricos existentes explica completamente estes resultados.
Estimando o Retorno das Ações com Decomposição do Índice Book-to-Market: Evidências na Bovespa
Authors: Almeida Juliano Ribeiro de , Eid Jr. William
Published: October 2019

A relação book-to-market (BM) difere entre empresas devido a diferentes expectativas em termos de fluxos de caixa e retornos esperados das ações. A hipótese central é que a evolução do BM, em termos de mudanças passadas no preço e valor patrimonial, contém informação sobre os fluxos de caixa futuros que pode ser utilizada para melhorar as estimativas de retornos esperados. Este artigo utilizou a base de dados da Economática para extrair uma amostra de ações de empresas não financeiras de capital aberto listadas na BOVESPA e testar essa hipótese. As regressões realizadas foram estimadas mensalmente durante o período de julho de 1996 a junho de 2008. Tanto para as large and mid caps quanto para as small caps, os resultados encontrados não favorecem essa hipótese e mostram que somente o BM mais recente é relevante para se prever os retornos dos ativos. Além disso, emissões e recompras de ações também estão relacionadas a fluxos de caixa futuros e se espera que possam melhorar as estimativas de retornos esperados. No entanto, os resultados encontrados não trazem evidências que favorecem essa afirmação.
Flexibilizando os Modelos de Estrutura a Termo da Classe Nelson-Siegel
Authors: De Rezende Rafael Barros
Published: October 2019

Este artigo compara as habilidades de interpolação de modelos não-paramétricos e paramétricos da estrutura a termo amplamente utilizados pelos principais bancos centrais do mundo. Buscando a combinação de alisamento e flexibilidade, um novo modelo da classe Nelson-Siegel é introduzido. Ele surge como uma extensão do modelo de Svensson (1994) e do modelo de cinco fatores proposto por De Rezende e Ferreira (2008) e Christensen Diebold e Rudebusch (2008). É mostrada a superioridade do modelo smoothing spline na interpolação das curvas spot e forward, bem como a vantagem do modelo proposto em relação a outros modelos Nelson-Siegel. A superioridade do smoothing spline, porém, vem com um custo: sua instabilidade ao interpolar os vértices iniciais da estrutura a termo. O modelo proposto, por outro lado, apresenta as propriedades desejáveis de alisamento e flexibilidade, especialmente ao interpolar as taxas forward e as taxas spot de médio e longo prazos.
Relatório Editorial - 2010
Authors: Leal Ricardo Pereira Câmara
Published: October 2019

A RBFin é o principal veículo para publicação de artigos acadêmicos em finanças do Brasil. O conteúdo da Revista permaneceu on-line e aberto e também foi mantida a revista impressa, graças ao auxílio do CNPq/Capes. A revista emprega o sistema Open Journal System para gerenciar o processo editorial. O cronograma de publicação da RBFin encontra-se rigorosamente em dia. A revista é indexada no EconLit, Google Scholar, Ebsco e Gale e listada nos diretórios JEL, Latindex e Cabell’s. A RBFin foi enquadrada como B1 na área de Administração do Qualis/Capes. O Corpo Editorial Científico é parcialmente renovado a cada ano e é formado por 18 membros provenientes de cinco países, sendo dez provenientes de cinco diferentes estados do Brasil. A taxa de aceitação foi de 22,9% para os artigos enviados em 2009 e de 19,7% para os enviados em 2010. A média de dias entre o recebimento e a aceitação para os artigos publicados em 2010 foi de 215. O pior caso foi de 525 dias. A média de dias entre o recebimento e a publicação foi de 367. O pior caso foi de 649 dias. A média de acessos por artigo até janeiro de 2011 foi 1027. Cento e dezessete indivíduos atuaram como avaliadores em 2010.
Previsão da volatilidade intradiária: análise das distribuições alternativas
Authors: Ceretta Paulo Sérgio , De Barba Fernanda Galvão , Vieira Kelmara Mendes , Casarin Fernando
Published: October 2019

A previsão da volatilidade tem sido de grande interesse tanto no âmbito acadêmico quanto profissional em todo o mundo. Não há, entretanto, um consenso sobre o melhor modelo a ser aplicado no processo de estimar a volatilidade. Novas modelagens têm incluído medidas de assimetria, mudanças de regime e diferentes distribuições. Destes fatos estilizados, poucos estudos têm sido feitos considerando as diferentes distribuições. Este trabalho visa investigar como a especificação da distribuição influencia a performance da previsão da volatilidade em dados intradiários do Ibovespa, usando o modelo APARCH. As previsões foram realizadas supondo seis distribuições distintas: normal, normal assimétrica, t-student, t-student assimétrica, generalizada e generalizada assimétrica. Os resultados obtidos evidenciaram que o modelo considerando a distribuição t-student assimétrica foi o que melhor se ajustou aos dados dentro da amostra, porém, na previsão fora da amostra, o modelo com distribuição normal apresentou melhor desempenho.
Modelagem dos Preços de Imóveis Residenciais Paulistanos
Authors: Alves Denisard Cneio de Oliveira , Yoshino Joe Akira , Pereda Paula Carvalho , Amrein Carla Jucá
Published: October 2019

Este trabalho analisa a formação dos preços dos imóveis da cidade de São Paulo e considerando em seu modelo hedônico, além das características intrínsecas, as características da vizinhança e o ambiente macroeconômico. O período analisado é de janeiro de 2001 a março de 2008. Os principais resultados foram: quanto mais longo for o período do financiamento imobiliário, maior será o preço do imóvel; a diminuição do spread dos juros bancários estimulam o mercado; e as interações entre a dummy de boom tanto com as características das moradias e com o spread de juros mostram que as variáveis de risco de mercado ganham importância relativa no modelo. Assim, as evidências sugerem que para a modelagem do indexador de preços de imóveis, os métodos usuais de médias simples, hedônico e vendas repetidas utilizados em diferentes países, são insuficientes. Precisam ser consideradas variáveis de risco de mercado e de crédito.
Case Report: Cardiac arrest due to traumatic coronary artery dissection treated by extracorporeal membrane resuscitation
Authors: Tanaka Kumiko , Nakada Taka-aki , Kadohira Tadayuki , Oda Shigeto
Published: October 2019

Traumatic coronary artery dissection, which is rare in blunt trauma, has high risk of acute myocardial infarction and cardiac arrest. A 44-year-old man who had a traffic accident was transferred to the emergency department with refractory ventricular fibrillation (VF). After conventional cardiopulmonary resuscitation, we introduced extracorporeal cardiopulmonary resuscitation (ECPR) and obtained return of spontaneous circulation with ST-elevation electrocardiogram at V4-6. Subsequent coronary angiography and intravascular ultrasound supported by extracorporeal membrane oxygenation (ECMO) revealed complete occlusions of left anterior descending and left circumflex artery due to dissections. Drug-eluting stents were placed with restorations of TIMI 2 flows. After ICU admission, his left ventricular function gradually recovered; he was successfully weaned from VA-ECMO on day 9. ECPR may be a valuable option to allow time and stable hemodynamic condition to treat the cause of cardiac arrest.
Randomized controlled trials in ophthalmology: a bibliometric study
Authors: AlRyalat Saif Aldeen , Abukahel Areen , Elubous Khaled Ali
Published: October 2019

Background: Randomized controlled trials (RCTs) are situated at the top of hierarchy of evidence-based medicine, where its number and quality are important in the assessment of quality of evidence in a medical field. In this study, we aim to assess the status of RCTs in Ophthalmology.

Methods: On 15th of May 2019, we performed a PubMed search for randomized controlled trials published in the field of ophthalmology using relevant filters and search terms. We categorized the results into specific topics in ophthalmology according to Medical Subject Heading (MeSH) database classification system. We used Altmetric explorer to identify journals and articles with the highest number of RCTs and highest citations.

Results: We found a total of 540,427 publications in the field of ophthalmology, of which only 11,634 (2.15%) of them were RCTs. ‘Retinal diseases’ was the topic with the highest number of RCTs, followed by ‘glaucoma’ and ‘conjunctival diseases’. The trial with highest number of citations was on retinal diseases. Only around 18% of all ophthalmology RCTs are published in the top 10 ophthalmology journals, with a maximum percentage of RCTs was (5.53%) published in Ophthalmology.

Conclusion: RCTs in ophthalmology primarily concern the retina, glaucoma, and a few other sub-topics, with little focus on sclera, orbit, and the eyelids. Most of the high impact RCTs are published in non-ophthalmology journals.
Sistem Klasifikasi Otomatis Volume Balok dengan Arduino
Authors: Ilmi Armina Syaiful , Muslihudin Muslihudin
Published: October 2019

Penggunaan teknologi baru dan canggih menjadi pilihan dunia industri untuk meningkatkan efisiensi produksi baik dari segi kualitas, kuantitas maupun penghematan biaya. Proses otomasi sistem kendali industri tidak akan lepas dari penggunaan perangkat elektronik, seperti halnya pengunaan berbagai macam sensor dan komponen penting lainnya. Pada penelitian ini merancang prototipe konveyor yang memisahkan otomatis balok berdasarkan ukuran volume, bertujuan untuk penghematan tempat produksi kecil dan sumber daya manusia. Perancangan perangkat keras terdiri dari microcontroller Arduino Mega 2560 menjadi penyimpan logika perintah dalam sistem,  sensor ultrasonic HC-SR04 sebagai sensor pengukur panjang, lebar dan tinggi barang, motor servo sebagai penyetop dan pemisah barang,  liquid crystal display sebagai penampil informasi dan motor dc menjadi penggerak konveyor. Pengujian sistem ini menggunakan barang penelitian 3 balok dengan ukuran berbeda yaitu 315 cm3, 480 cm3 dan 525 cm3. Berdasarkan hasil pengujian menunjukkan klasifikasi volume balok dapat bekerja dengan baik, dengan tingkat rata-rata error 5,4 untuk volume ukuran 315 cm3; 3,2 untuk volume 480 cm3; dan 2,33 untuk volume 525 cm3 dan dengan standar deviasi sistem klasifikasi otomatis volume balok sebesar σ = 9,40.
Sistem Presensi Berbasis RFID Menggunakan Raspberry Pi 3
Authors: Muttaqin Imam Wildan , Rahman Arif
Published: October 2019

Sistem presensi mahasiswa banyak dilakukan secara konvensional. Sistem presensi otomatis yang ada pun memiliki kinerja yang lambat dan tidak mampu diperbarui secara otomatis. Sistem presensi mahasiswa berbasis RFID menggunakan Raspberry Pi 3 diharapkan mampu menangani masalah-masalah tersebut. Sistem pada penelitian ini dibangun menggunakan modul RFID jenis MIFARE RC522, Raspberry Pi 3 model B, dan RTC DS1307. Prinsip kerja sistem ini yaitu menerima masukan berupa hasil identifikasi ID pada kartu RFID, kemudian hasilnya diolah Raspberry Pi 3 sekaligus menentukan respon, dan merekap data presensi pada server. Hasil presensi berupa nama mahasiswa dan mata kuliah ditampilkan pada LCD 16x2. Sebagai hasil akhir, server mengirim data presensi yang dapat ditampilkan pada komputer klien melalui situs web. Pengujian sistem menunjukkan jarak maksimal identifikasi ID sejauh 4,5 cm dengan rata-rata waktu pembacaan selama 150,53 ms. Penambahan RTC DS1307 menjadikan sistem tidak harus terhubung dengan internet untuk update secara otomatis. Selain itu, penelitian ini juga membuktikan bahwa penghalang kayu, karet, keramik, kaca, plastik, dan akrilik, tidak mempengaruhi jarak dan waktu dalam proses identifikasi kartu RFID. Namun penghalang jenis logam dapat menghalangi proses identifikasi kartu RFID.
Baby Loss Awareness Week: ending the postcode lottery on therapy
Authors: Plumb Oliver
Published: October 2019

Every year, thousands of people experience the loss of a baby in pregnancy, at or soon after birth, and in infancy. Here, Oliver Plumb from Group B Strep Support demonstrates the difference psychological therapy can have on those people
The forgotten women of gynaecology
Authors: Downes Heidi
Published: October 2019

The inhumane use of female slaves in the development of gynaecological techniques has not been fully acknowledged. It is time to formally recognise these formidable women, says Heidi Downes
Chronic heart disease in pregnancy: exploring Marfan syndrome
Authors: Dunn Cheryl
Published: October 2019

Coronary heart disease is the biggest killer in the UK, causing more than a quarter of deaths in 2018 ( British Heart Foundation, 2018 ). Congenital defects are the most common cause of heart disease in pregnancy ( Wylie and Bryce, 2016 ). This article will discuss Marfan syndrome and the impact this has on pregnancy and childbirth. Current literature and research will be appraised and discussed to explore mode of delivery during the second stage of labour and calculate the most appropriate method of delivery. Additionally, this article will address how the midwife can support women with Marfan syndrome during the pregnancy booking, antenatal period and intrapartum period without labelling them, and discuss how this may be achieved in relation to the uncertainty reduction communication theory.
The Scottish Clinical Supervision Model for midwives
Authors: Key Susan , Marshall Helene , Martin Caroline J Hollins
Published: October 2019

The Nursing and Midwifery Council (NMC) model of statutory supervision for midwives ceased in 2017 following a change in UK legislation. In response, the Scottish Government and NHS Education for Scotland (NES) worked with NHS Health Boards to develop a new employer-led model of clinical supervision. The aim of this model is to help midwives provide improved services, safer care and improved outcomes for women and infants in keeping with professional regulation. The new Scottish Clinical Supervision Model is also designed to increase midwives' personal wellbeing and help them deal with the everyday challenges of clinical practice. The design is a radical departure from the previous NMC model because it incorporates facilitation and coaching methods which teach midwives to respond, reflect and restore self, and reduce stress and increase resilience. In an attempt to improve nurturing leadership, the key components of this new model are underpinned by a person-centred approach, during which the supervisor provides unconditional positive regard and empathy towards the supervisee. Equipping midwives to develop contemporary supervision is supported by NES through online education.
A comparative study of socioeconomic status, perceived social support and psychological distress of mothers of children with and without disabilities
Authors: Alwhaibi Reem Mohammed , Zaidi Uzma , Alzeiby Ebtesam , Alhusaini Adel
Published: October 2019

Background/Aims

Quality of life has been defined as a measure of a person's physical wellbeing, psychological state, and social relationships. However, comparisons of psychological distress, socioeconomic status, and social support between mothers of children with and without disabilities have been limited, particularly in Saudi Arabia. The aim of this study is to comparatively evaluate the socioeconomic status, perceived social support, and psychological distress of mothers of children with and without disabilities.

Methods

The Socio-Demographic Information Form, the Multidimensional Scale of Perceived Social Support, and the Depression Anxiety Stress Scales were completed by 200 mothers of children with cerebral palsy or Down's syndrome and 100 mothers of children without disabilities.

Results

Welch's test indicated significant differences between the two groups on the total Depression Anxiety Stress Scales and all its subscales (<0.01) and the Multidimensional Scale of Perceived Social Support Friends subscale (0.02).

Conclusions

Mothers of children with disabilities perceived high levels of overall social support, which might have reduced their psychological distress. It is recommended for rehabilitation centres to organise support groups for family members. It will also be beneficial for families of children with disabilities, if heath sector policy makers can review and develop effective socioeconomic policies to improve their standards of living.
Strategic use of branding for competitiveness: the rationale for branding and marketing agricultural products of African countries
Authors: Alemu Getachew Mengistie
Published: October 2019

Growers of agricultural products and key actors involved in the value chain in advanced and high-income developing countries commonly use brands in marketing agricultural products and strengthening competiveness in the market. However, the tool is little known and used by farmers and stakeholders involved in the processing and marketing of agricultural products in Africa. There are encouraging recent developments in the use of brands to market agricultural products, with the support of development partners such as the World Intellectual Property Organization and the Department for International Development (DFID). This article aims to explain the significance of agriculture, the challenges in marketing agricultural products and the importance of promoting the use of brands in marketing African countries' agricultural products. A review of experiences in the use of brands in marketing agricultural products will be subject to a subsequent article.
Who enables sustainable Fair Trade? The current status and challenges of Fair Trade in Korea
Authors: Hwang Seonyoung , Kim Sunhwa , Jeong Jihyun , Jang Seungkwon
Published: October 2019

This study aims to explore the status of Fair Trade in Korea and suggest directions Korean Fair Trade might take for its sustainable development and practices. Initiated in the early 2000s, Fair Trade in Korea has been growing ever since. It has seen the emergence of various participants in Fair Trade value chains. The diversity of participants in the value chain has led to a variety of practices. It can be meaningful for researchers and actors to explore who implements Fair Trade in Korea in what ways and to discuss how Fair Trade can be developed sustainably. The authors examine the characteristics of the participants and their activities through a value chain analysis of Korean Fair Trade, and discuss ways forward for sustainable Fair Trade.
Role of platelet-rich fibrin in enhancing the viability of autologous microlobular fat graft: an animal-based experimental study
Authors: Koento Trimartani , Reksodiputro Mirta Hediyati , Marimpan Olvi Nancy
Published: October 2019

BACKGROUND Tissue fat has been used as a fat graft in plastic reconstructive surgery since ancient times by surgeons. However, an issue with this usage is that fat gets absorbed by up to 30–50%, especially centrifuged fats. The aim of this study was to compare the survival of microlobular fat, centrifuged fat, microlobular fat with plateletrich fibrin (PRF), and centrifuged fat with PRF. METHODS Subcutaneous fat was taken from the stomach area and divided into two parts, microlobular fat and centrifuged fat, and processed by adding PRF as follows: 1) microlobular fat without PRF; 2) microlobular fat with PRF; 3) centrifuged fat without PRF; and 4) centrifuged with PRF. These fat grafts were implanted into rabbit earlobes. Each procedure was performed repeatedly nine times for a total of 36 repetitions for all groups. RESULTS Microscopic evaluation revealed the highest number of adipocytes in the microlobular fat with PRF group (mean = 1,932) and the highest number of fibroblasts (mean = 600.5) compared to those in other treatment groups, although the difference was not statistically significant. There was more neovascularization in the microlobular fat group (mean = 228.5), but it was not statistically significant. CONCLUSIONS Addition of PRF to microlobular fat graft enhances the number of adipocytes and fibroblasts, including the enhancement of neovascularization.
A recent update of the diagnostic methods for tuberculosis and their applicability in Indonesia: a narrative review
Authors: Susilawati Tri Nugraha , Larasati Riska
Published: October 2019

Tuberculosis (TB) is a major global problem, especially with the high prevalence of HIV-TB co-infection. Delayed diagnosis and continual transmission contribute to high mortality in Indonesia, which has the third highest incidence of TB in the world, after China and India. Therefore, early diagnosis is needed to reduce the number of cases and to administer therapy to prevent the transmission of bacteria. The diagnosis of TB remains a challenge in clinical practice due to poor sensitivity and the requirement of skilled staff in microscopic tests, the slow growth Mycobacterium in culture, and the low number of bacilli present in extrapulmonary TB. Despite being the golden standard for TB diagnosis, cultures require 2–8 weeks to grow. Other methods for diagnosing TB include interferon-gamma release assays and serologic tests such as the tuberculin skin test. Recently, the World Health Organization recommended the GeneXpert MTB/RIF assay for diagnosing TB. This review presents the current state of TB epidemiology and various methods for TB diagnosis. In particular, the paper provides an in-depth discussion about the GeneXpert MTB/RIF assay that has been made available recently in selected tertiary hospitals in Indonesia.
A glance at molecular mechanisms underlying cisplatin-induced nephrotoxicity and possible renoprotective strategies: a narrative review
Authors: Pandhita Bashar Adi Wahyu , Rahmi Deliana Nur Ihsani , Sumbung Nielda Kezia , Waworuntu Bernardino Matthew , Utami Regina Puspa , Louisa Melva , Soetikno Vivian
Published: October 2019

Cisplatin is a platinum-based drug that is usually used for the treatment of many carcinomas. However, it comes with several devastating side effects, including nephrotoxicity. Cisplatin toxicity is a very complex process, which is exacerbated by the accumulation of cisplatin in renal tubular cells via passive diffusion and transporter-mediated processes. Once cisplatin enters these cells, it induces the formation of reactive oxygen species that cause cellular damage, including DNA damage, inflammation, and eventually cell death. On a small scale, these damages can be mitigated by cellular antioxidant defense mechanism. However, on a large scale, such as in chemotherapy, this defense mechanism may fail, resulting in nephrotoxicity. The current article reviews the molecular mechanisms underlying cisplatin-induced nephrotoxicity and possible renoprotective strategies to determine novel therapeutic interventions for alleviating this toxicity.
Voxel-wise analysis of 18F-fluorodeoxyglucose metabolism in correlation with variations in the presentation of Alzheimer’s disease: a clinician’s guide
Authors: Abdul Aziz Siti Aishah , Jia Ling Loh , Ahmad Saad Fathinul Fikri , Nordin Abdul Jalil , Ibrahim Normala , Nuruddin Arlina , Tunan Elinda , Rosalina  , Saripan M. Iqbal , Suppiah Subapriya
Published: October 2019

BACKGROUND Diagnostic imaging can be applied in the management of Alzheimer’s disease as it provides structural and functional information to exclude possible secondary causes and offers additional information, especially in atypical cases of Alzheimer’s disease. The utility of positron emission tomography/computed tomography (PET/CT) can help in the noninvasive diagnosis of Alzheimer’s disease by voxel-wise quantification of cerebral 18F-fluorodeoxyglucose (FDG) metabolism. 

METHODS This prospective study was conducted among 10 subjects with Alzheimer’s disease and 10 healthy control subjects who underwent neuropsychological testing and 18F-FDG PET/CT scans. Images of the brain were postprocessed using voxel-wise analysis and segmented into 20 regions of interest. The standardized uptake value (SUV)max/SUVmean/standard deviation of SUVmean results were analyzed accordingly and correlated with the subjects’ Montreal cognitive assessment (MoCA) results that were adjusted for age and education level. 

RESULTS Hypometabolism at the right parietal lobe significantly correlated with increasing age and lower MoCA scores. Global hypometabolism was observed in subjects who had advanced Alzheimer’s disease but preserved primary somatosensory cortices (S1) region metabolism. Predominance of frontal lobe hypometabolism was a feature of subjects with Alzheimer’s disease having associated depressive symptoms. 

CONCLUSIONS 18F-FDG PET/CT voxel-wise analysis can be used for quantitative assessment and can assist clinicians in the diagnosis of Alzheimer’s disease and other variations of the disease spectrum.
Do Democratic governors lower economic freedom? A regression discontinuity approach
Authors: Hankins William B. , Hoover Gary A.
Published: October 2019

Using a panel of US states over the period 1985–2010, we examine how Democratic governors affect economic freedom compared to Republican governors. Economic freedom is measured using the Economic Freedom of North America Index. Given the emphasis that this index places on smaller government, we expect that having a Democratic governor leads to less economic freedom. However, using a regression discontinuity approach, we find that Democratic governors do not reduce economic freedom compared to Republican governors elected by a similar margin. An implication of this result is that governors must appeal to the median voter when making policy.
Reliving a crisis through a feature film: Corporate image from online user-generated versus official media perspectives
Authors: Heavens Andrew , Osburg Victoria-Sophie , Yoganathan Vignesh
Published: October 2019

A crisis presents a severe challenge for every company, particularly, when it has ethical implications. Previous research has shown how the presentation of a crisis in the media can negatively affect corporate image. After surviving such a crisis, its adverse connotations may resurface
years later in the minds of stakeholders, for example, through a feature film. The consequences of how a crisis re-emergence affects corporate identity, especially in the digital age of media proliferation, is not yet sufficiently understood. Hence, this paper outlines how a crisis reemergence
impacts on corporate image through a detailed literature review and the discussion of a case. This paper shows the need to appreciate differences between UGC (user generated content, outside company control), and official news media (potentially manipulable) in relation to corporate reputation
management, and consequently, the importance of targeted image restoration in light of crisis re-emergence.
Immunotherapy for insulin-dependent diabetes mellitus
Authors: Dedov I. I. , Abugova I. A. , Shamhalova M. Sh. , Shishko P. I.
Published: October 2019

The autoimmune nature of insulin-dependent diabetes mellitus (IDDM) is currently undeniable. In the 80s, some features of its pathogenesis were determined: on beta cells of patients with newly diagnosed IDDM, overexpression of class I HLA antigens was detected; on beta and alpha cells of isolated islets of Langerhans, expression of class II HLA antigens in combination with tumor necrosis factor (TNF-alpha) and gamma-interferon (gamma-IF) was detected; the presence or absence of Asp-57 in the N-end of the beta1 domain of the HLADQ beta chain has been shown to be positively associated with IDDM in humans and NOD mice; it was revealed that macrophage interleukin-1 (IL-1) and TNF-alpha have a damaging effect on beta cells: IL-1 exhibits selective beta-cell cytotoxicity in low molar concentrations, and the effect of IL-1 is potentiated by TNF-alpha; it was determined that early infiltration during the development of inflammation of pancreas in BB rats is caused by macrophages and monocytes; destruction of beta cells is performed by T-helpers and natural killers. Thus, the autoimmune concept of the disease necessitates the use of immunotherapy to slow the development of IDDM.
P. A. Wunder (on the occasion of the 90th birthday annivetsary)
Authors: Problems of endocrinology Editorial team of
Published: October 2019

May 5, 1995 marks the 90th anniversary of the birth of a talented scientist, wonderful teacher, wonderful person Pavel Abramovich Wunder. P.A. Wunder, who has devoted himself to serving science since his student years, is a highly erudite scientist, a well-known theorist and researcher. Throughout his creative life, P. A. Wunder has been developing a scientific direction in the study of the interaction of endocrine glands, their nervous regulation, and physiology of reproduction. P.A. Wunder combines a high level of professional qualification with a broad biological horizons, which allowed him to creatively develop and deepen the concept of plus-minus interaction by his teacher M. M. Zavadsky, bringing it in line with the achievements of modern science.
Response to G. A. Gerasimov’s comments on E. P Kasatkina’s paper "Diffuse nontoxic goiter. Problems in classification and taxonomy"
Authors: Kasatkina E. P
Published: October 2019

The article devoted to the response to G. A. Gerasimov’s comments on E. P Kasatkina’s paper "Diffuse nontoxic goiter. Problems in classification and taxonomy"
Nitric oxide synthase (NOS) genes in the pathogenesis of diabetes mellitus and its complications
Authors: Kondratyeva Ye. I. , Kosyankova T. V.
Published: October 2019

The article devoted to the nitric oxide synthase (NOS) genes in the pathogenesis of diabetes mellitus and its complications
A new approach to therapy of type 2 diabetes mellitus in patients with excessive body weight
Authors: Mkrtumyan A. M.
Published: October 2019

The article devoted to the new approach to therapy of type 2 diabetes mellitus in patients with excessive body weight
A rare case with Icenko-Cushing syndrome caused by multiple bilateral benign and malignant adrenocortical tumors
Authors: Molitvoslovova N. N. , Belova Yu. Yu. , Yushkov P. V. , Kuznetsov N. S. , Marova Ye. I. , Vanushko V. E.
Published: October 2019

The article is devoted to the descripition of the rare case with Icenko-Cushing syndrome caused by multiple bilateral benign and malignant adrenocortical tumors.
Type 2 multiple endocrine neoplasia syndrome
Authors: Beltsevich D. G. , Kuznetsov N. S. , Peterkova V. A. , Polyakova Ye. . Yu. , Smorshchok V. N. , Zaletayev D. V.
Published: October 2019

The article devoted to the Type 2 multiple endocrine neoplasia syndrome
A Cognitive Load Theory Simulation Design to Assess and Manage Deteriorating Patients
Authors: Say Richard , Visentin Denis , Betihavas Vasiliki , Minutillo Susannah
Published: October 2019

Background

Cognitive load theory (CLT) uses an understanding of brain architecture for educational design, with implications for simulation. Since working memory is limited, minimising extraneous cognitive load improves learning of new tasks (intrinsic load) and use of existing knowledge (germane load). This study evaluates the effectiveness of low-fidelity simulation (LFS) utilising CLT principles in the assessment and management of the deteriorating patient (AMDP).

Method

CLT design principles informed the choice of LFS and simulation design. The self-rated ability of 13 undergraduate nurses across seven aspects of AMDP was measured in a pre-post design.

Results

Self-rated ability increased from 2.98 (SD = 0.19) to 4.47 (SD = 0.12) (p < 0.001), with improvements across all AMDP aspects.

Conclusion

This study indicates that CLT informed design has benefits for simulation. LFS may be preferred to high fidelity simulation for AMDP teaching and medical simulation for novice learners.
Umberto Eco’s semiotics of the text: Theoretical observations and an analysis of the parable of the banquet
Authors: Traini Stefano
Published: October 2019

In this article I have attempted to use Umberto Eco’s semiotics of the text in order to analyze the famous “parable of the banquet,” which has come down to us in three versions from the gospels of Luke (14,15–24), Matthew (22,1–14) and Thomas (logion 64). In particular I have tried to consider (i) the socio-cultural context, or in other words the Sitz im Leben of the community within which the parable was written; (ii) the narrative structure of the parable, with the narrative nodes that stimulate the reader to cooperate in the work of interpretation and to draw inferences; (iii) the way in which the Model Author is portrayed in the text; (iv) the kind of Model Reader who is prefigured in the parable. The analysis has shown how in the parable of the banquet, the original level (deriving directly from the preaching of Jesus) characterized by a salvationist and social slant is always overlaid with another level that is hortatory, pedagogical or ecclesiological, and which takes on different connotations according to the different contexts. Generally the Evangelists are suggesting to their communities that they make changes in their behavior ranging from renunciation of wealth to the resetting of social ties, from a stance of constant vigilance to the practice of an active faith, from healthy detachment from worldly frivolity to a rigorous asceticism. Thus the editorial layers reveal differing narrative nodes in function of particular interpretative responses, different Model Authors and different Model Readers.
Telmisartan prevents development of obesity and normalizes hypothalamic lipid droplets
Authors: Rawish Elias , Nickel Laura , Schuster Franziska , Stölting Ines , Frydrychowicz Alex , Saar Kathrin , Hübner Norbert , Othman Alaa , Kuerschner Lars , Raasch Walter
Published: October 2019

The AT1 receptor blocker telmisartan (TEL) prevents diet-induced obesity. Hypothalamic lipid metabolism is functionally important for energy homeostasis, as a surplus of lipids induces an inflammatory response in the hypothalamus, thus promoting the development of central leptin resistance. However, it is unclear as to whether TEL treatment affects the lipid status in the hypothalamus. C57BL/6N mice were fed with chow (CONchow) or high-fat diet (CONHFD). HFD-fed mice were gavaged with TEL (8 mg/kg/day, 12 weeks, TELHFD). Mice were phenotyped regarding weight gain, energy homeostasis, and glucose control. Hypothalamic lipid droplets were analyzed by fluorescence microscopy. Lipidomics were assessed by performing liquid chromatography-mass spectrometry in plasma and hypothalami. Adipokines were investigated using immunosorbent assays. Glial fibrillary acidic protein (GFAP) was determined by Western blotting and immunohistochemical imaging. We found that body weight, energy homeostasis, and glucose control of TEL-treated mice remained normal while CONHFD became obese. Hypothalamic ceramide and triglyceride levels as well as alkyne oleate distribution were normalized in TELHFD. The lipid droplet signal in the tanycyte layer was higher in CONHFD than in CONchow and returned to normal under TELHFD conditions. High hypothalamic levels of GFAP protein indicate astrogliosis of CONHFD mice while normalized GFAP, TNFα, and IL1α levels of TELHFD mice suggest that TEL prevents hypothalamic inflammation. In conclusion, TEL has anti-obese efficacy and prevented lipid accumulation and lipotoxicity, which is accompanied by an anti-inflammatory effect in the murine hypothalamus. Our findings support the notion that a brain-related mechanism is involved in TEL-induced weight loss.
A la mejor Minerva, Divina Madre de la sabiduría: Panegírico a la Virgen de las Nieves en la Universidad de San Marcos en 1721
Authors: Flórez Gloria Cristina
Published: October 2019

La devoción mariana es una de las más importantes de la Cristiandad y su desarrollo y evolución se ha relacionado con diversas situaciones vividas a través de los siglos en diferentes espacios geográficos. El culto a la Virgen de las Nieves se implantó en nuestro territorio a partir del siglo xvi y tiene gran importancia para nuestra Universidad como se comprueba en la documentación relacionada con las celebraciones que se ofrecieron en su honor. Nos interesa estudiar el sermón ofrecido en la fiesta del 5 de agosto de 1721 en la catedral de Lima y estuvo a cargo del doctor Juan de Sarricolea y Olea, profesor de Teología, quien posteriormente fue obispo de Santiago de Chile y de Cuzco.
Demócratas, mediocres y técnicos. Las tensiones del futuro universitario en el Perú
Authors: Lynch Nicolás
Published: October 2019

Este artículo trata de la relación entre el abandono estatal, la mediocridad, la razón democrática y la razón tecnocrática en la universidad peruana en el último siglo. La secuencia se plantea como la lógica y el conflicto entre distintos discursos que buscan darle un rumbo a la institución universitaria en el proceso de reforma de la misma que empieza con la impronta del movimiento universitario de Córdoba en 1918 y no termina hasta el presente. Resalta la formación de una razón democrática y su devenir en los distintos procesos de crisis y cambio de la universidad como el discurso que le puede dar futuro a la producción de conocimientos en el Perú.
Aproximaciones de la sociología de género hacia la violencia de la mujer en Lima Metropolitana
Authors: Blossiers Mazzini Carolina
Published: October 2019

En Lima Metropolitana las interacciones que se dan entre la mujer y el varón se producen y reproducen al interior de la familia, ahí se construyen las representaciones sociales y culturales sobre lo femenino y masculino. También en la familia se configura la sexualidad, los comportamientos violentos, las normas y los valores. Asimismo, advertimos cómo desde la aparición de la propiedad privada, el matrimonio monógamo, la familia patriarcal y relaciones de poder, genera la inequidad del varón en relación a la mujer quien se considera superior, y se extinguen las oportunidades de las mujeres para desarrollarse plenamente en la vida social. La Organización Mundial de la Salud y la Organización Panamericana de la Salud (1998) demuestran que el problema de la violencia hacia la mujer se inicia desde la niñez, continúa en la adolescencia, la etapa reproductiva hasta la senectud. Además, la OMS (2016) destaca que el Perú, ocupa el tercer lugar en el mundo por violencia sexual y feminicidio, después de Etiopía y Bangladesh.
La poesía quechua: rapto de la escritura y corpus contemporáneo (siglos XX y XXI)
Authors: Espino Relucé Gonzalo
Published: October 2019

La poesía quechua contemporánea la entendemos como la afirmación de una cultura de resistencia, su vigencia como lengua y como ejercicio de escritura se produce en todo el siglo xx y se afianza en el siglo xxi. Se trata de un tipo de texto que se realiza en el entramado de la tradición quechua y la impronta de sus aprendizajes de la cultura occidental y al mismo tiempo pone en primer plano cómo y con qué criterios se abordaría el corpus de la poesía quechua escrita contemporánea. Su abordaje tendría que ser revisada desde el rapto de la escritura que implica atender a nociones como proceso, escritura y zona literaria. Se trabajó sobre un universo de fuentes que va de 1904 al 2017.
Dietary Interventions for Autism Spectrum Disorder: A Meta-analysis
Authors: Fraguas David , Díaz-Caneja Covadonga M. , Pina-Camacho Laura , Moreno Carmen , Durán-Cutilla Manuel , Ayora Miriam , González-Vioque Emiliano , de Matteis Mario , Hendren Robert L. , Arango Celso , Parellada Mara
Published: October 2019

CONTEXT:

Dietary interventions such as restrictive diets or supplements are common treatments for young people with autism spectrum disorder (ASD). Evidence for the efficacy of these interventions is still controversial.

OBJECTIVE:

To assess the efficacy of specific dietary interventions on symptoms, functions, and clinical domains in subjects with ASD by using a meta-analytic approach.

DATA SOURCES:

Ovid Medline, PsycINFO, Embase databases.

STUDY SELECTION:

We selected placebo-controlled, double-blind, randomized clinical trials assessing the efficacy of dietary interventions in ASD published from database inception through September 2017.

DATA EXTRACTION:

Outcome variables were subsumed under 4 clinical domains and 17 symptoms and/or functions groups. Hedges’ adjusted g values were used as estimates of the effect size of each dietary intervention relative to placebo.

RESULTS:

In this meta-analysis, we examined 27 double-blind, randomized clinical trials, including 1028 patients with ASD: 542 in the intervention arms and 486 in the placebo arms. Participant-weighted average age was 7.1 years. Participant-weighted average intervention duration was 10.6 weeks. Dietary supplementation (including omega-3, vitamin supplementation, and/or other supplementation), omega-3 supplementation, and vitamin supplementation were more efficacious than the placebo at improving several symptoms, functions, and clinical domains. Effect sizes were small (mean Hedges’ g for significant analyses was 0.31), with low statistical heterogeneity and low risk of publication bias.

LIMITATIONS:

Methodologic heterogeneity among the studies in terms of the intervention, clinical measures and outcomes, and sample characteristics.

CONCLUSIONS:

This meta-analysis does not support nonspecific dietary interventions as treatment of ASD but suggests a potential role for some specific dietary interventions in the management of some symptoms, functions, and clinical domains in patients with ASD.
Impact of the volume and the profile of volatile fatty acids in the rumen fermentation on cow productivity and milk composition
Authors: Katarzyna Katarzyna , Pecka-Kiełb Ewa , Zachwieja Andrzej
Published: October 2019

The aim of the research was to establish relations between the selected rumen fermentation products and the milk composition in dairy cows. The experiment was conducted on 10 Polish Holstein-Friesian cows of black and white variety. The animals were kept in the free stall housing system and fed with the total mixed ration (TMR). The herd’s milk production was assessed using the A4 method and the milk analyses were obtained from the milk recordings. The rumen digesta were sampled two hours after the morning delivery of TMR using a stomach pump. The sampled digesta were diluted with buffer, homogenized and the obtained suspension was analysed using gas chromatograph with the FID detector to
determine the total concentration of volatile fatty acids (VFA) and the
percentage of individual VFAs. Milk composition was obtained from the RW-1 reports, and the Pearson correlation coefficient was calculated for
the obtained parameters. It was determined that propionate and the relation of propionate to butyrate in the rumen digesta increased the protein content and its fractions in milk. The volatile fatty acids utilization coefficient in the rumen digesta a positive correlation to protein contents and a negative correlation to the level of caseins in milk were shown. Processes taking place in the cow rumen significantly influence the composition and quality of milk. The knowledge of volatile
fatty acids content and the of individual VFAs allows for the management of the rumen fermentation in order to obtain better technological parameters of milk.
Las palabras que definen: Análisis del discurso ecológico
Authors: Míguez Néstor
Published: October 2019

Este artículo examina los diversos lenguajes que se usan en el ámbito dela ecología, a partir de las palabras y conceptos bíblicos vinculados a estatemática. Lo hace de a pares: creación/naturaleza, bienes/recursos, cuidado/conservación, dominar/laborar. Las palabras “vida” y “destrucción”son transversales en todas las otras definiciones. También considera susimplicaciones en el ámbito de la economía capitalista imperante y las idolatríasque conlleva.
Justicia y Nueva creación - Una lectura de Isaías 11, 1-10
Authors: Campusano (Tirsa) María Cristina Ventura
Published: October 2019

Se viven tiempos de crisis muy grave, pero también de resistencias queademás tienen una característica nueva. El estudio propone, a partir deuna mirada atenta a Is 11,1-9 reflexionar desde realidades de crisis actuales. Para esto, se plantea que el texto contiene una propuesta de justicia y nueva creación, como parte de un programa de resistencia, donde el espíritu de Dios, la ruah, en sus múltiples manifestaciones, provoca la transformación de las relaciones humanas, basadas en engaño, escasez provocada, con las cuales se legitiman acciones injustas contra las personas pobres y, por lo tanto, también contra la naturaleza. La invitación es a abrir la posibilidad para un vivir en la fidelidad a Dios, expresada en el cuidado y en la atención a los pobres y la alianza. dicho de otra manera, el texto propone pensar en justicia en relación a una nueva creación, como propuesta para el vivir bien. Pero, sin pretender olvidar que siempre va a ser un reto practicar la justicia en un mundo no justo. A pesar de esto, la justicia emerge no como opuesta a injusticia sino como propuesta de nueva creación.
Conhecer os desejos da terra profecias de Gomer no livro de Oséias
Authors: Cardoso Nancy
Published: October 2019

Releitura do livro de Oseias na perspectiva dos processos de intesificaçãoda agricultura no século VIII no reino do norte e a resistência camponesaem especial na recuperação e reimaginação das práticas e vivência de mulheres com a terra em diálogo com as lutas da agroecologia feminista hoje
¡Ya no sube el cortador contra nosotros! Interpretar la Biblia con conciencia ecológica
Authors: Castillo David
Published: October 2019

El artículo buscará unir crisis ecológica y texto bíblico en un ejercicio deinterpretación, considerando textos selectos del Antiguo Testamento pararesponder a los problemas ya planteados. Se hará una breve síntesis entorno a algunos trabajos previos en hermenéutica ecológica, categoría dentrode la hermenéutica bíblica que ha asumido la ecología como sujeto hermenéutico.Luego, buscaremos soñar con la interpretación de dos textos,tal y como soñó el profeta Isaías, con el día en que podamos celebrar, juntocon la creación entera, la caída de toda tiranía que tale y corte la vida.