bluuebunny/crossref_metadata_2025 huggingface dataset:
KONTRIBUSI LATIHAN MULTIBALL TERHADAP PENGEMBANGAN KEMAMPUAN PUKULAN FOREHAND DRIVE PADA ATLET PTM SAMATURU
Authors: Musto Aldin , Suwo Rahedin , - Rosti , Sabrin Laode Maklum , Haris Iyan Nurdiyan , Nugraha Aldy
Published: January 2025

Tujuan dari penelitian ini adalah untuk mengetahui seberapa besar pengaruh latihan multiball terhadap kemampuan atlet PTM Samaturu untuk melakukan pukulan forehand drive. Jenis penelitian yang digunakan dalam penelitian ini adalah pre-eksperimen yang dirancang sebagai satu grup pre-tes setelah tes. Penelitian ini melibatkan atlet yang berusia antara 13 dan 18 tahun. Penelitian ini menggunakan 15 sampel. Tes ketepatan forehand drive Instrument digunakan. Latihan multiball dilakukan selama enam minggu, tiga kali seminggu. Studi ini menggunakan uji-t dengan taraf signifikan 5% dan prasyarat uji normalitas dan homegenitas. Hasil penelitian menunjukkan bahwa nilai thitung = 11.992 lebih besar dari nilai ttabel = 1.7531, dan nilai sig adalah 0.00 hingga 0.05. sehingga Ho ditolak dan Ha diterima. Hasil penelitian menunjukkan bahwa Ha dapat diterima dan latihan multiball meningkatkan kemampuan pukulan forehand drive atlet PTM Samaturu. Kelompok eksperimen yang diberikan latihan multiball menunjukkan peningkatan sebesar 32.48% dalam kemampuan pukulan mereka. Dalam penelitian ini, metode latihan multiball dapat meningkatkan kemampuan pukulan forehand drive atlet.
Anticorrosive Zr-containing Sol-gel Сoatings on AA5056 Aluminum Alloy
Authors: Shloma O.A. , Abrashov A.A. , Gavrilova N.N. , Zhilina O.V. , Grigoryan N.S. , Novikov E.V.
Published: January 2025

Due to the high toxicity of chromating solutions, which include highly toxic hexavalent chromium compounds, and the conversion coatings formed in them, laws have been adopted in most countries restricting or completely prohibiting the use of Cr(VI) compounds in mechanical engineering and electronics products. This publication is devoted to the development of the process of applying a protective sol-gel zirconiumcontaining coating to the surface of the aluminum alloy AA5056. The optimization of the process parameters for the deposition of a functional sol-gel coating was carried out, the physicochemical and mechanical properties of the coating, which could become an alternative to toxic chromate coatings, were investigated. During the work, it was found that the Zr-containing sol-gel coating is comparable in abrasion resistance to chromate films. The results of polarization measurements showed that the application of a multilayer sol-gel coating improves its protective ability. The increase in protective ability is also confirmed by exposure in the salt mist chamber. The time until the first signs of corrosion appear is 435 hours.
Anti-corrosive properties of superhydrophobic coating on steel obtained by electrochemical method
Authors: Tsygankova L.E. , Rodionova L.D. , Uryadnikov A.A. , Gorlov D.A. , Lomakina I.A. , Shel N.V.
Published: January 2025

The protective efficiency of a superhydrophobic (SHP) coating on a steel electrode obtained by electrodeposition of copper and zinc with subsequent treatment in an ethanol solution of myristic acid was studied in a number of environments. The SHP coating is characterized by a contact wetting angle equal to 157±2°. Corrosion tests were carried out gravimetrically under conditions of 100% humidity, distilled water, in the gas and liquid phases of 1 and 3% SO2 solutions, as well as NaCl (50 g/L) and NACE (g/L: NaCl – 5; СH3 COOH - 0,25) in the presence of 1 excess atmosphere of CO2 for 240 h. The superhydrophobic coating exhibits 100% protective effect Z when samples are exposed to 100% humidity and distilled water at a virtually constant value of contact angles. In the gas phase of NaCl + CO2 and NACE + CO2 solutions, the protective effect is 78 and 71% respectively. In the first case, superhydrophobicity is retained, in the second - hydrophobicity, but subsequent exposure to air helps restore superhydrophobicity. After the liquid phase, the coating retains its hydrophobicity, but its superhydrophobicity is not restored when exposed to air. In the gas phase of 1 and 3% SO2 solutions, Z is 94 and 64% respectively. In the first case, the coating retains its superhydrophobicity, while in the second case, it retains its hydrophobicity, which, however, turns into superhydrophobicity when exposed to air. Polarization and impedance measurements in a NaCl solution for 168 hours showed that the presence of the SHP coating on the steel electrode causes a slowdown in the anodic process on the electrode compared to an unprotected electrode. The Z value of the coating at the initial moment is close to 90% and decreases over time, reaching 70% after 168 hours.
A NEW PROCEDURE : BAYESIAN SELECTION TO FIND THE BEST OF GEOMETRIC POPULATION UNDER GENERAL LOSS FUNCTION
Authors: Hathoot Samira Faisal
Published: January 2025

In many practical situations the experimenter is confronted with the problem of choosing the best one of a number of populations or categories or ranking them according to their performance . This paper derives a procedure for selecting the better of Two Geometric populations employing a decision-theoretic Bayesian framework with Beta prior under general loss function .the numerical results for this procedure are given by using Math Works Matlab ver 7.0.1 with different loss functions constant , linear and quadratic , where in one equation we can obtain the Bayes risk for the three types of the loss functions : constant , linear and quadraticÂ  .
Monte Carlo Simulation and Applications
Authors: Sheet Abd Al Kareem I , Saeed Nadia Adeel
Published: January 2025

The Monte Carlo simulation technique is one of the common computational tools used to imitate and follow up complex real life systems and their development with time. Variables of a disease problem were defined and the mathematical model for this problem was constructed. The numerical solution of this model was compared with the computational simulation of Â Markov Renewal Process of the type '' Birth and Death ''. We obvious from the results we obtained the efficiency of the Monte Carlo simulation technique and through out extended time periods episodes.Â
Inter-professional Team Collaboration among Health Care Team Members in Critical Care Units: Targeting Cooperating, Coordinating, and Partnership in Najaf Governorate, Iraq
Authors: Al-Twigey Maitham , AL-Fayyadh Sadeq
Published: January 2025

Background: Inter-professional collaboration (IPC) among the health care team in critical care units is essential for delivering high-quality and safe care for patients and getting the desired health care outcome for patients. In Critical Care Units (ICU and CCU), an IPC approach comprises cooperation, coordination, and partnership among healthcare specialists from different disciplines to deliver thorough and patient-centred care to critically ill patients. Objective: Determining the level of IPC among health care team members in ICUs and CCUs. Methods: A descriptive cross-sectional design that targeted (n = 364) nurses, physicians, and clinical pharmacists in ICUs and CCUs, The Assessment of Interprofessional Team Collaboration Scale II (AITCS-II), was employed in this study. Results: The IPC level among health care team members in ICUs and CCUs was substandard. The partnership domain was weak with a mean score (MS) of 2.31, cooperation was moderate with a MS of 2.51, and coordination was weak with a MS of 2.17. The overall ICP was poor with a MS of 2.33. Conclusion: As hypothesised, the overall IPC covering all three main domains (partnership, cooperation, and coordination) among health care team members in critical care units is substandard. It is imperative for Iraqi nursing colleges to prioritise educating their students on inter-professional collaboration and its significance in delivering quality patient care. Instilling a clear understanding of their roles in healthcare among students is vital to cultivating a culture of teamwork and its advantageous outcomes for both patients and healthcare teams. Nurses should engage in specialised workshops that focus on professional collaboration within healthcare settings to reinforce and build upon their academic knowledge of their crucial role(s). This may help in improving their inter-professional teamwork, leading to better patient care.
Assessing the Efficacy of Sanctions in Conflict Resolution Evolution: A Case Study of Russo-Ukraine War
Authors: Shujahi Farhat Konain , Minhas Ahmed Saeed , Areej Aayla
Published: January 2025

Wars and conflicts have been redefining international politics. Engaging in conflicts elicits many reactions from different nations throughout the globe, and one such reaction is the use of sanctions to restrict the exacerbating rivalries. In the context of the ongoing Russo-Ukraine War, the ineffectiveness of sanctions may be attributed to the regime type in Russia and the intricate interplay between various strategic elements. Multiple variables have contributed to this outcome. Russia's ability to withstand from challenges, together with its effective measures in reaction to enforced sanctions, is assumed to be primarily its national will and resilience. The paper is to examine the efficacy of sanctions in settling the war, specifically focusing on the instance of Russia's invasion of Ukraine in 2022. Additionally, it seeks to assess the efficiency of sanctions put on Russia in 2014 besides endeavoring to reveal the aspects that contribute towards making penalties inter-alia sanctions effective and pragmatic.
АНАЛІЗ ПРИЧИН ТА ЮРИДИЧНОЇ ВІДПОВІДАЛЬНОСТІ ЗА НЕЗАКОННИЙ ВИДОБУТОК БУРШТИНУ
Authors: Moroz О. T. , Likho O. A.
Published: January 2025

На сьогоднішній день Україна посідає друге місце у світі за запасами бурштину та вирізняється помітно низькою вартістю даного виду дорогоцінного каміння порівняно з іншими країнами. Як наслідок, попит на бурштин, видобутий на території України є надзвичайно високим та провокує збільшення обсягів його незаконного видобування.Метою нашої роботи був теоретичний аналіз причин та юридичної відповідальності за незаконний видобуток бурштину та з’ясування кількості офіційно зафіксованих злочинів проти довкілля за ст. 239 та ст. 240 Кримінального кодексу України.З наукових літературних джерел ми з’ясували, що в структурі екологічних злочинів незаконне видобування корисних копалин загальнодержавного значення займає особливе місце. Негативними наслідками злочинів цієї категорії є заподіяння збитку економіці та екології країни в тих регіонах, в яких розміщені поклади корисних копалин і ведеться їх активне видобування. Кількість екологічних злочинів, пов'язаних із порушенням правил охорони або використання надр, постійно збільшується. Негативно впливає на стан боротьби з вказаними злочинами і відсутність відповідної окремої криміналістичної методики, структурним елементом якої є криміналістична характеристика даного виду злочинів.Ми також проаналізували питання, пов’язані з відповідальністю за збут, придбання, зберігання, передачу, пересилання, перевезення, переробку бурштину, законність походження якого не підтверджується відповідними документами. У цьому аспекті виділяється правове регулювання, організаційне регулювання та економічне регулювання. Проблемою є те, що більшість видів відповідальності мають поблажливі санкції, а тому не зупиняють зловмисників від скоєння повторного діяння. Крім того, більшість нелегальних видобувачів безробітні, вони не мають постійного джерела доходу, тому багато з них штрафи просто не сплачують. Офіційні документи за 2018–2020 рр. наводять дані про значну кількість таких випадків, що свідчить про наявність різних причин цього злочину, які призводять до негативного впливу на довкілля.Зроблено узагальнення про необхідність подальшого вдосконалення нормативних документів, щодо сприяння усунення причин та посилення відповідальності за незаконний видобуток бурштину.
ДИНАМІКА ПОШИРЕННЯ ВАРООЗУ БДЖІЛ НА ТЕРИТОРІЇ УКРАЇНИ ЗА 2021 РІК
Authors: Poltavchenko T. V. , Budnik Z. M. , Chechet O. M. , Lytvynenko O. P. , Miroshnichenko O. I.
Published: January 2025

Проведено порівняльний аналіз динаміки епізоотичного процесу щодо ураження бджіл кліщем вароа в Україні  за 2021 рік. Наведено дані в розрізі областей. Визначено зони ризику з умовним поділом України на неблагополучну, загрозливу та тимчасово благополучну території. Доведено, що варооз, всесвітня проблема бджільництва, оскільки внаслідок інвазії бджолині сім’ї слабшають і зменшуються, завдається шкода навколишньому середовищу та відбувається зниження продуктивності ентомофільних рослин. Вчені відзначають, що останнім часом паразит змінився. Одним із найнебезпечніших видів є Varroa destructor Anderson and Trueman, 2000. Варооз бджіл на території України поширений повсемісцево. Так протягом 2021  року було проведено  215685 досліджень з них позитивний результат було отримано в 4739 випадках, середня інвазованість вароозом  бджіл за 2021  рік склала 2,2%. Відповідно рівня інвазування бджіл вароозною інвазією територію України можна умовно поділити на три території ризику: неблагополучна – з рівнем інвазування від 4 до 14%, загрозлива – з рівнем інвазування від 1 до 4%, тимчасово благополучна – з рівнем інвазування від 0 до 1%. Найбільш ураженими на території України виявилися  Волинська, Рівненська, Кіровоградська, Чернівецька області. В статті представлені різноманітні методи боротьби, включаючи фізичні, зоотехнічні, генетичні та біологічні. Встановлено, що найпопулярнішою стратегією боротьби є використання акарицидних хімікатів. Боротьба з вароозом заснована на максимальному звільненні бджолиних сімей від досягнення найменшої шкоди для них в результаті застосування препаратів.
СУЧАСНИЙ СТАН МЕЛІОРОВАНИХ ҐРУНТІВ СТЕПОВОЇ ЗОНИ ХЕРСОНСЬКОЇ ОБЛАСТІ
Authors: Kyrylchuk A. M. , Shukailo S. P. , Turchyna K. P.
Published: January 2025

Розробка і впровадження заходів зі збереження і поліпшення родючості ґрунтів вимагає наявності всебічної достовірної інформації про їх еколого-агрохімічний стан. У статті розглянуто результати роботи з ґрунтового моніторингу та узагальнено результати агрохімічної паспортизації сільськогосподарських угідь Херсонської області за 2011–2020 роки досліджень (Х та ХІ тури), рівня кислотності та солонцюватості ґрунтів. Виходячи з матеріалів суцільної агрохімічної паспортизації земель  сільськогосподарського призначення, в Херсонській області, з 645,42 тис. га обстежених за 2016–2020 рр. (ХІ тур) земель, налічується 54,98 тис. га, що потребують вапнування. Узагальнені результати досліджень за ХІ тур агрохімічної паспортизації свідчать, що площа несолонцюватих ґрунтів в області складає 65,5 тис. га (10,1%), що порівняно з попереднім туром більше на 1,5%. Кількість солонцюватих ґрунтів у області виявлена на рівні майже 90% (579,9 тис. га), в тому числі слабосолонцюватих та середньосолонцюватих ґрунтів – 545,6 тис. га (84,5%), сильносолонцюваті займають – 29,7 тис. га (4,6%), солонці – 4,7 тис.  га (0,7%). Гіпсова меліорація за 2011–2020 роки в Херсонській області була проведена на площі 47,4 тис. га, в тому числі за 2020 на площі 2,3 тис. га. Гіпсових меліорантів було внесено в кількості 166,6 тис. тонн, у тому числі в 2020 році 8,5 тис. тонн. Загальна площа меліорованих земель у складає 47,4 тис. га, обсяг внесених меліорантів становить 166,6 тис. тонн, що в середньому складає 3,3 т/га.Хімічна меліорація солонцюватих ґрунтів є основним заходом зменшення ступеню деградації, проте такі роботи досить енергоємні та потребують значних капіталовкладень, тому на цей час проводяться вкрай рідко лише в поодиноких господарствах. Розробка і впровадження заходів зі збереження і поліпшення родючості ґрунтів вимагає наявності всебічної достовірної інформації про їх еколого-агрохімічний стан. Її значення особливо зростає в сучасних умовах, характерною ознакою яких є мізерні обсяги застосування хімічних меліорантів. Основним джерелом інформації про стан родючості ґрунтів і зміну їх агрохімічних властивостей в процесі сільськогосподарського виробництва є результати щорічного агрохімічного моніторингу ґрунтів на землях сільськогосподарського призначення.
ЗРОШУВАЛЬНА МЕЛІОРАЦІЯ ЗЕМЕЛЬ В УМОВАХ ЗМІНИ КЛІМАТУ
Authors: Kyrylchuk A. М. , Hryshchenko O. М. , Ventsuryk A. V. , Biedunkova O. O.
Published: January 2025

Надмірно стрімка зміна клімату через підвищення середньої температури впливає на збільшення інтенсивності посушливих умов. Нераціональне використання запасів води на постійне забруднення водних ресурсів лише погіршують ситуацію. В регіонах, які раніше на зазнавали посух, спостерігаються посушливі умови спричинені зростанням попиту на воду та збільшенням її дефіциту. Зміна режиму зволоження призведе до зміни водного стоку річок, водність найбільших річок країни може знизитись на 30%, а малих – зовсім припинитися. За запасами води, що формуються на території країни й є доступними для використання, Україна є однією з найменш забезпечених країн Європи. Основними джерелами надходження води в ґрунт є атмосферні опади, а також підґрунтові води за умови неглибокого їх залягання. Зрошення земель є одним із основних факторів інтенсифікації землеробства в районах з недостатнім та нестійким зволоженням. В умовах обмежених водних ресурсів важливим резервом поливної води є комунально-побутові та промислові стічні води. Побутові та промислові стічні води на 99% складаються з води та на 0,1% з органічних та неорганічних сполук, включаючи живильні макроелементи, такі як азот, фосфор та калій, а також живильні мікроелементи. Домішка промислових стоків може додавати токсичні з’єднання, але не в небезпечній кількості, тому беруть до уваги лише чутливість зрошуваних сільськогосподарських культур до бору. Наявність біля великих тваринницьких комплексів значних обсягів стічних вод та гнойових відходів створює серйозну екологічну проблему. Одним з ефективних шляхів її розв’язання є використання цих стоків для зрошення, що забезпечує біологічне очищення. У стічних водах тваринницьких комплексів уміст загального азоту досягає 0,3%, фосфору – 0,08%, калію – 0,7%, проте в процесі підготовки стоків до зрошення вміст цих речовин зменшується.Використання комунально-побутових і промислових стічних вод для зрошення виконує екологічну функцію, оскільки забезпечує доочищення стічної води у ґрунті та запобігає забрудненню довкілля, поверхневих водних об’єктів-приймачів цієї води та зменшить навантаження на ресурс природної води.
IPS dan Trik Pelajar Pancasila pada Merdeka Belajar dalam Menyongsong Era Society 5.0 di SMA Negeri 3 Banyuasin 1
Authors: Damayati Nina , Taufik Mirna , Sukmaniar Sukmaniar , Puji Hartono Deni , Oktavia Maharani , Asiyah Siti
Published: January 2025

Merdeka belajar pada era society 5.0 merupakan upaya yang dilakukan pemerintah untuk memulikan pendidikan di Indonesia pasca pademi covid-19 diharapkan learning loss akibat pademi bisa ditanggulangi dengan kurikulum medeka, namun karena merdeka belajar ini merupakan kebijakan baru yang dibuat pemerintah maka siswa disekolah-sekolah masih banyak yang belum mengetahui tentang profil pelajar pancasila, merdeka belajar, dan era society 5.0 untuk itu tim PKM akan melakukan pengabdian dengan memberikan sosialisasi tentang tips dan trik pelajar pancasila pada merdeka belajar dalam menyonsong era society 5.0 di SMA N 3 Banyuasin 1. Metode yang digunakan dalam pelaksaan PKM ini adalah dengan menggunakan metode ceramah terbimbing dimana para pemateri memberikan ceramah berupa tips dan trik pelajar pancasila pada merdeka belajar dalam menyonsong era society 5.0. Hasil pelaksanaan kegiatan PKM ini mendapakan respon positif dari siswa-siswa perserta PKM hal ini dapat dilihat dengan adanyan peningkatan pengetahuan siswa tentang tip dan triks pelajar pancasila pada merdeka belajar dalam menyosong Era society 5.0 berdasarkan pre test dan post test dari 6,2% ke 86% untuk jawaban iya.
Dampak Program Edukasi Kesatuan dan Kolaborasi Terhadap Pertumbuhan Jemaat GKSI Syalom
Authors: Florensia Silvia
Published: January 2025

Kehidupan jemaat masa kini sangat mempengaruhi pertumbuhan gereja. Namun pertumbuhan gereja membutuhkan kesatuan didalamnya. Seperti yang dialami oleh GKSI Syalom, Kalimantan Barat saat ini. Berdasarkan hasil pengamatan pengabdi menemukan problematika yang terjadi pada jemaat yaitu kurangnya kesatuan dan kolaborasi yang berakibat pada melemahnya dinamika kehidupan bergereja. PkM ini bertujuan untuk memberikan wawasan kepada jemaat pentingnya membuat gereja semakin bertumbuh melalui kolaborasi atau kerja sama antar jemaat. Dalam penelitian ini dijelaskan pentingnya kolaborasi dan kesatuan melalui perspektif teologis. Hasil atau luaran yang didapatkan melalui edukasi ini adalah jemaat menjadi membangun kerja sama satu dengan yang lain, melalui program-program gereja dari hal kecil hingga yang terbesar.
Comparative anlysis of immune response, intestinal microbiota and susceptibility to Bacillus Thuringiensis bacteria of the colorado potato beetle Leptinotarsa Decemlineata
Authors: Tereshchenko D. S. , Grizanova E. V. , Shelikhova E. V. , Dubovskiy I. M.
Published: January 2025

Biological insecticides based on Bacillus thuringiensis (Bt) bacteria are highly specific in their action against various types of insects and are considered safe for the environment. One of the most common pests of nightshade crops worldwide is the Colorado potato beetle, Leptinotarsa decemlineata. Due to its wide distribution across different climatic regions and rapid development of resistance to chemical insecticides, it raises questions about the mechanisms behind its ecological plasticity and rapid resistance formation to biological insecticides. In this study, we investigated indicators of cellular and humoral immunity, enzyme activity in the antioxidant and detoxification systems, gut microbiota, and susceptibility to Bt bacteria in larvae of Colorado potato beetles from different areas of the Novosibirsk Region (NSO). The total number of hemocytes and lysozyme-like antibacterial activity in the hemolymph of insects from the Vengerovsky district of NSO was 1.5–2 times higher than in larvae from the Ordynsky district of NSO. The activity of detoxification enzymes in the intestines and fat body of larvae from Ordynsky increased by 1.7–2.5 times compared to the Hungarian insect group. It has been shown that bacteria of the family Enterobacteriaceae and genera Citrobacter are the dominant groups of intestinal microbiota in both regions of NSO, but bacteria of the genus Spiroplasma predominate in larvae from Ordynsky. It was also found that insects did not differ in their level of sensitivity to B. thuringiensis, the development of bacterial infection in the intestines of Colorado potato beetles from different parts of their range causes a two- to three-fold increase in phenoloxidase activity in the hemolymph, while a 1.5-fold increase in the total number of hemocytes has also been recorded in insects from the Ordynsky district in NSO. This suggests that insects from different geographical populations are able to effectively develop a protective strategy against entomopathogens through a balance between innate and induced resistance mechanisms.
Pharmacological Doses of Thiamine Benefit Patients with Charcot–Marie–Tooth Neuropathy, Changing the Thiamine Diphosphate Levels and Dependent Enzyme Regulation
Authors: Artiukhov A. V. , Solovjeva O. N. , Balashova N. V. , Sidorova O. P. , Graf A. V. , Bunik V. I.
Published: January 2025

Charcot–Marie–Tooth (CMT) neuropathy is a polygenic disorder of peripheral nerves with no effective cure. Thiamine (vitamin B1) is a neurotropic compound improving neuropathies. Our pilot study characterizes therapeutic potential of daily oral administration of thiamine (100 mg) in CMT neuropathy and its molecular mechanisms. The patient hand grip strength is determined before and after the thiamine administration along with the blood levels of the thiamine coenzyme form (thiamine diphosphate, ThDP), activities of endogenous (without ThDP in the assay medium) holo-transketolase and total (with ThDP in the assay medium) transketolase, and the transketolase activation by ThDP [1-(holo-transketolase/total transketolase),%], corresponding to the fraction of the ThDP-free apo-transketolase. Single cases of administration of sulbutiamine (200 mg) or benfotiamine (150 mg) reveal their effects on the assayed parameters within those of thiamine. Administration of thiamine or its pharmacological forms increases the hand grip strength in the CMT patients. Comparison of the thiamin status in patients with varied forms of CMT disease to that of the control subjects without diagnosed pathologies has not found significant differences in the average levels of ThDP, holo-transketolase or transketolase distribution between the holo and apo forms. However, the transketolase regulation by thiamine/ThDP differs in the control and CMT groups. In the assay medium, ThDP does not activate transketolase of CMT patients, while the activation is statistically significant in the control group. Thiamine supplementation in vivo paradoxically decreases endogenous holo-transketolase in CMT patients, the effect not observed in the control group. Correlation analysis reveals sex-specific differences in relationships between the parameters of thiamine status in the control subjects and patients with CMT disease. Thus, our findings link physiological benefits of thiamine supplementation in CMT patients to the changes in their thiamine status, characterized by the blood levels of ThDP and transketolase regulation.
The Content of Primary and Secondary Carotenoids in the Cells of the Cryotolerant Microalgae Chloromonas reticulata
Authors: Dymova O. V. , Parshukov V. S. , Novakovskaya I. V. , Patova E. N.
Published: January 2025

Snow (cryotolerant) algae often form red (pink) spots in mountain ecosystems on snowfields around the world, but little is known about their physiology and chemical composition. The content and composition of pigments in the cells of the cryotolerant green microalgae Chloromonas reticulata have been studied. An analysis of the carotenoids content in green (vegetative) cells grown in laboratory conditions and in red resting cells collected from the snow surface in the Subpolar Urals was carried out. There were photosynthetic pigments − carotenoids such as neoxanthin, violaxanthin, anteraxanthin, zeaxanthin, lutein and β-carotene. Among the carotenoids, the ketocarotenoid astaxanthin, which has a high biological activity, was also found. It was established that the cultivation of algae at low positive temperature (+6 °C) and moderate illumination (250 μmol quanta/(m2⋅s) contributed to the accumulation of all identified carotenoids, including extraplastidic astaxanthin. In addition to the pigments, fatty acids accumulated in the algae cells. The data obtained allow us to consider the studied microalgae as a potentially promising species for the production of carotenoids.
Dose-Dependent Alterations of Lysosomal Activity and Alpha-Synuclein in Peripheral Blood Monocyte-Derived Macrophages and SH-SY5Y Neuroblastoma Cell Line by upon Inhibition of mTOR Protein Kinase – Assessment of the Prospects of Parkinson’s Disease Therapy
Authors: Bezrukova A. I. , Basharova K. S. , Baydakova G. V. , Zakharova E. Y. , Pchelina S. N. , Usenko T. S.
Published: January 2025

To date, the molecular mechanisms of the common neurodegenerative disorder Parkinson’s disease (PD) are unknown and, as a result, there is no neuroprotective therapy that may stop or slow down the process of neuronal cell death. The aim of the current study was to evaluate the prospects of using the mTOR molecule as a potential target for PD therapy due dose-dependent effect of mTOR kinase activity inhibition on cellular parameters, the alteration of which is associated with pathogenesis of the PD. The study was performed on peripheral blood monocyte-derived macrophages and SH-SY5Y neuroblastoma cell line. As a result, we have first showed that inhibition of mTOR by Torin1 only at a concentration of 100 nM affects the level of the lysosomal enzyme glucocerebrosidase (GCase), encoded by the GBA1 gene, mutations in which are a high-risk factor for PD, and leads also to a decrease in pathological phosphorylated (Ser129) form of alpha-synuclein, an increase in its aggregation resistant tetrameric form in absence of the changes in lysosomal enzyme activities and lysosphingolipids concentrations. Inhibition of the protein kinase mTOR may be a promising approach for developing therapy for PD, in particular GBA1-associated PD.
Differences in the Effects of Beta-Hydroxybutyrate on Mitochondria Biogenesis, Markers of Oxidative Stress and Inflammation in Young and Old Rat Tissues
Authors: Nesterova V. V. , Babenkova P. I. , Brezgunova A. A. , Samoylova N. A. , Sadovnikova I. S. , Semenovich D. S. , Andrianova N. V. , Gureev A. P. , Plotnikov E. Y.
Published: January 2025

One of the therapeutic approaches to age-related diseases is to affect the metabolism of the body’s cells through certain diets or their pharmacological mimetics. The ketogenic diet significantly affects the energy metabolism of cells and the functioning of mitochondria, which is being actively studied in various age-related pathologies. In this study, we investigated the effect of the ketogenic diet mimetic beta-hydroxybutyrate (BHB) on the gene expression of proteins regulating mitochondrial biogenesis (Ppargc1a, Nrf1, Tfam), quality control (Sqstm1), the work of the antioxidant system (Nfe2l2, Gpx1, Gpx3, Srxn1, Txnrd2, Slc6a9, Slc7a11), and the inflammatory response (Il1b, Tnf, Ptgs2, Gfap) in the brain, lungs, heart, liver, kidneys, and muscles of young and old rats. In addition, we analyzed mitochondrial DNA (mtDNA) copy number, the accumulation of mtDNA damage, and the level of oxidative stress by the concentration of thiobarbituric acid-reactive substances (TBARS), and reduced glutathione level. We showed that aging in a number of organs disrupts mitochondrial biogenesis and the functioning of the cell’s antioxidant system, which was accompanied by increased oxidative stress and inflammation. Administration of BHB for 2 weeks had different effects on organs of young and old rats. In particular, BHB increased the expression of genes of proteins associated with mitochondrial biogenesis and the antioxidant system, especially in the liver tissue and muscles of the young but not the old rats. At the same time, BHB contributed to the reduction of TBARS in the kidneys of the old rats. Thus, our study has shown that the administration of ketone bodies can significantly affect gene expression in organs, especially in young rats, by increasing mitochondrial biogenesis, improving the antioxidant system and partially reducing the level of oxidative stress. However, these changes were much less pronounced in old animals.
BRAND-MANAGEMENT OF THE ENTERPRISE AS A FACTOR OF SUCCESS OF INNOVATIVE ACTIVITY
Authors: GONCHAR О. , TROCIKOWSKI TADEUSZ ,   Khmelnytskyi National University
Published: January 2025

In the current conditions of globalization changes in the international market and increasing competition, the struggle of producers for the consumer is intensifying. Increasing efforts are being made in the field of innovation, to develop innovative products that meet potential demand. Under such conditions, the use of brand management is an effective tool to increase business activity and competitiveness of the enterprise. Leading companies that lead the international market, the success of their business is largely due to the creation of a successful brand. Today, some Ukrainian companies, which in many respects lag behind their foreign counterparts, can already talk about the importance of using expansion tools that have been tested in practice in Western countries, including brand management.
Peculiarities and principles of effective brand management of enterprises, its role in ensuring the efficiency and competitiveness of enterprises in modern conditions are studied. It is concluded that for the success of brand management of a modern enterprise it is important to implement not only classical but also specific management principles. The main ones have been identified. The comparative characteristic of traditional marketing and brand-oriented approaches to enterprise management is carried out.
The actual scientific and practical task of further development of theoretical provisions and methodological support for the formation and effectiveness of the brand is highlighted.
It is stated that in the mechanism of brand-oriented management of the enterprise the central place belongs directly to the development and promotion of the brand, coordination of its impact on the marketing complex and on the market activity of the enterprise.
CURRENT TRENDS IN HIGHER EDUCATION IN UKRAINE: THE IMPACT OF COVID-19 ON FORMAL, NON-FORMAL AND INFORMAL EDUCATION
Authors: Kovalchuk S. , Franchuk L. ,   Khmelnytskyi National University
Published: January 2025

The processes taking place in Ukraine and around the world under the influence of the pandemic caused by COVID-19 have consequences in the field of higher education. It can be argued that educational activities, especially in relation to formal and dual education, have undergone significant impact and some transformational changes under the influence of the pandemic. These changes have both positive consequences for the wider use of modern digital technologies and learning platforms, and negative consequences for distancing and conducting classes on-line.
Thus, under conditions of full and partial quarantine, a new paradigm has been formed in the field of higher education, which includes signs and trends in the economy and society as a whole, caused by the general turbulence of processes, on the one hand, and modern features caused by distancing under the influence of COVID. -19.
The article generalizes the characteristics of the synergistic effect of marketing and logistic support of enterprises and the definition of this concept on the basis of systematization of the properties of the effect of the synergy of marketing-logistic systems. The main methods and models that can be used to evaluate the synergy effect are described, deficiencies and advantages of existing methods are identified. The features of the application of methods and models of assessment in calculating the synergy effect of marketing and logistics providing of companies are revealed.
THE ROLE AND PLACE OF INTELLECTUAL CAPITAL IN THE SYSTEM OF MANAGEMENT AND SUPPORT OF INNOVATIVE DEVELOPMENT OF ENTERPRISE
Authors:   Khmelnytskyi National University, GRABOVSKAYA І.
Published: January 2025

The article is devoted to the study of modern objective and theoretical prerequisites for the use of intellectual capital in the innovative development of the enterprise. The creative context of economic development is outlined, which determines qualitatively new transformational changes in the innovation management system. It is emphasized that creativity is a powerful business tool for successful activities of employees / managers of the company, and the activities of the organization as a whole, allows for profitable growth of most companies. The essence of the concepts of “intellectual capital” and “creative capital” is studied, the approaches to the definition of the concept of “intellectual and creative capital” are analyzed, the basic characteristics of creative management of the enterprise are given. The integrative approach to innovation management has been improved and the main components that are to ensure optimal efficiency of development and achievement of the enterprise goals are seen. The necessity of formation of strategy of use of intellectual and creative capital of the enterprise in innovative activity and its basic elements according to the purposes of the general strategy of the organization is substantiated. Approaches to the analysis of the effectiveness of the use of intellectual and creative capital in the management of innovative activities of the enterprise using the matrices of strategic analysis are studied. This makes it possible to identify the position of the enterprise in the coordinates of the matrix and to determine the appropriate typical priority management decisions. The approach to the choice of priority management decisions on the use of intellectual capital in the management of innovative activities of the enterprise is substantiated.
METHODOLOGY OF INFORMATION PROTECTION
Authors: MEISH A. , MATVIYCHUK O. ,   Khmelnytskyi National University
Published: January 2025

As you know, the larger the business, the more difficult it becomes to control. In the beginning, its owner or director can keep everything under control, and with its development it becomes difficult for one person to organize all the processes. What aspects should be paid attention to, what past should be excluded, and what is new should be added to the enterprise, what accents should be placed in the control processes – we will reveal in this article.
Any business is a set of certain resources. These include those that have a material expression (real estate, equipment, corporate rights) and those that are expressed in intangible form (information about the activities of the enterprise, its trade secrets).
Qualitatively formed processes are the key to the success of any company.
The development of a modern economy based on the use of new technologies, the creation of new materials, the analysis of large data sets, the development of new management systems leads to a change the principles of competition. Competition has gone beyond traditional notions of competition in existing markets. That’s why the purpose of this article is to convey to the head that if his company is promising, it has income, it is already at risk. Raiders have a number of policies, moves that will illegally or even legally leave the company without income. In this article, we have presented recommendations, a number of actions to modernize and move away from the established past, complexes and structures that the company should contain. In the article the problems concerning the directions of the state policy in the field of development of information security are investigated. Based on the analysis of scientific literature in the work it is noted that information security is a state of protection of the individual, society, state from information that is harmful or illegal, from information that has a negative impact on the consciousness of the individual, hinders the sustainable development of the individual, society and state. Thus, before the owner of the enterprise before its immediate opening (the best option) or during the operation of the enterprise there are a number of tasks to which he cannot be irresponsible.
INNOVATIVE RESOURCE POTENTIAL OF THE ENTERPRISE: BUILDING OF EFFECTIVE MODELS
Authors:   Khmelnytskyi National University, NYZHNYK O.
Published: January 2025

The basic approaches in formation of strategies of innovative development of the enterprises on the basis of use of resource potential are considered, the algorithm of distribution of resources in model of strategic innovative development has been constructed. Evaluation of models of strategic innovative development of enterprises indicates the presence of a significant number of different approaches to modeling the innovative activities of economic entities. Both classical economic and mathematical models are used to describe innovation processes, which are adapted taking into account the influence of the innovation factor on the final result, and specially developed models in which such a factor is fundamental. This review is far from complete and covers only the most common applications of modeling. The use of adequate models will allow to form an adequate strategy of innovative development of the enterprise, to correctly assess its consequences, which will help consolidate the market position of the enterprise and increase its competitiveness. Therefore, we can say that the innovative development of an industrial enterprise in the context of globalization should be based on the marketing and logistics management concept, the essence of which is to realize the bilateral interests of market participants – both the economic agent initiating the exchange and its counterparty – the consumer. The results of the formed model of strategic innovation potential of the enterprise solve the problems of conformity of the number of employees and available resources to the production needs of the enterprise and become input parameters for its implementation, taking into account individual features of organization of enterprises, conditions of their functioning in the external environment. their logical sequence with the possibility of rational distribution of powers between the teams of different units, united by a common task. The clarity of the obtained results allows to change the type of innovation strategy in accordance with changes in the external and internal environment, focusing the attention of management on the reorientation of priorities of innovative development of the enterprise, which may arise in response to changes in the environment.
MODELLING THE INFLUENCE OF RESOURCE POTENTIAL ON THE RESULTS OF THE PRODUCTION ACTIVITY OF A SEWING ENTERPRISE
Authors: PROSKUROVYCH O. , ALEKSEICHUK A. ,   Khmelnytskyi National University
Published: January 2025

The main purpose of this article is to study the state, analysis, modeling and forecasting the impact of resource potential on the results of production activities of the garment enterprise. The scientific article analyzes and econometric modeling and forecasting the volume of marketable products of the garment factory depending on the number of staff, cost of funds and inventories, which allows to assess the impact of resource potential on changes in output at the enterprise.
The results of the production activity of the garment factory are quite ambiguous, as from 2014 to 2018 it increases production and sales, increases the number of staff, cost of tools and labor, improves their efficiency while reducing gross and net profits and increasing costs. However, in the reporting year compared to the previous year there is a gradual slowdown in production and sales activities, reduction of staff, cost of fixed assets and deteriorating efficiency of means of production, labor potential and efficiency of the garment factory as a whole.
Correlation-regression analysis of the results of production activities to change the main components of resource potential (number of staff, value of fixed assets and inventories) allowed to determine the impact of selected factors on changes in the volume of marketable products. A three-factor model of linear character, power dependence, trend model was constructed and the Cobb-Douglas function was used to characterize the variation in the volume of garments production. The constructed models have a high value of the coefficient of determination, their parameters are reliable according to Student’s criterion. They are adequate according to Fisher’s criterion, so they are used to forecast the volume of marketable products.
DIGITAL ECONOMY AND ITS INFLUENCE ON THE DEVELOPMENT OF ORGANIZATIONS
Authors: RUDNICHENKO Ye , HAVLOVSKA N. , SUHODOLIA S. , LISOVSKYI І. , YADUKHA S. ,   Khmelnytskyi National University
Published: January 2025

The article proves the importance of the impact of the digital economy on the development of organizations and the relevance of the introduction of digital technologies, which is confirmed by the ranking of the most expensive companies in the world. An analysis of the concept of “digital economy” as an economic category was conducted by the author. The digital economy is one of the main trends of the twenty-first century. Extremely rapid development of technologies and the introduction of artificial intelligence in almost all spheres of society cause transformation processes not only in production processes but also in management. The ranking of the most expensive companies in the world demonstrates the transition to the “digital age”, and major market players invest in such prospects. Despite the different approaches to the interpretation of basic concepts in the digital economy, most scientists state the irreversible changes and the presence of transformations in almost all aspects and segments of business. Organizational changes are an integral part of the activities of organizations, which determine not only the peculiarities of their functioning, but also are the key to their survival and development. The implementation of organizational changes in the digital economy has its own specific features caused by the need to use advanced technologies. A higher level of technologies requires a review of management processes in order to implement effective changes. The author’s definition of digital economy was offered in the article. Thus, the digital economy is a consequence of the transformation of other types of economy that preceded its development. That is, the digital economy is a kind of symbiosis of the knowledge economy and globalization processes, which have become the impetus for the development of digital transformations in absolutely all spheres. The digital economy has a complex structure and includes the IT sector, manufacturing and / or marketing of products using information-communication technologies and related services. Digitization of almost all aspects of human life causes the transformation of the processes of development of organizations and requires a new vision of instrumental support of such processes.
ASSESSMENT OF THE NBU’s MONETARY POLICY IMPACT ON LENDING TO THE REAL SECTOR OF UKRAINIAN ECONOMY
Authors: OLIINYK А. , GORDEEVA Т. ,   Khmelnytskyi National University
Published: January 2025

The article examines the main approaches to determining the essence of monetary policy, which had been analyzed and systematized at great length. It is very important to mention that the use of the concept of “monetary policy” by scientists is common, which is often interpreted as identical to the concept of “money and credit policy”. However, recently, given the global trends in the monetary sphere, the NBU Council considers it appropriate to initiate amendments to the legislation of Ukraine in terms of replacing the term “money and credit policy” with the concept of “monetary policy”. It is established that monetary instruments are one of the most important tools of state influence on lending to the real sector of the economy. In the practice of implementing monetary policy, it is customary to distinguish the main regimes that ensure the effectiveness of the policy itself, and the essence of each is based on the choice of the nominal indicator chosen by the NBU. We consider that achieving equilibrium in the monetary market and ensuring economic growth depends on the right choice of monetary policy instruments and the mechanism of their implementation. Using the regression analysis, the influence of the dependence of the change in the value of loans in the national currency on the change in the NBU’s discount rate was determined. The indicators of banks’ activity in the lending market of the real sector of the domestic economy are analyzed. The influence of the NBU’s main monetary instruments on lending to the real sector of the economy is determined and substantiated.