bluuebunny/crossref_metadata_2025 huggingface dataset:
Inhibitory Effect of Natural Phenolic Compounds onAspergillus parasiticusGrowth
Authors: Pizzolitto Romina P. , Barberis Carla L. , Dambolena José S. , Herrera Jimena M. , Zunino María P. , Magnoli Carina E. , Rubinstein Héctor R. , Zygadlo Julio A. , Dalcero Ana M.
Published: March 2015

Considering the impact ofAspergillusspecies on crops, it appears to be highly desirable to apply strategies to prevent their growth, as well as to eliminate or reduce their presence in food products. For this reason, the aims of this investigation were to evaluate the effects of ten natural phenolic compounds on theAspergillus parasiticusgrowth and to determine which physicochemical properties are involved in the antifungal activity. According to the results of minimum inhibitory concentration (MIC) values of the individual compounds, isoeugenol, carvacrol, and thymol were the most active phenolic components (1.26 mM, 1.47 mM, and 1.50 mM, resp.), followed by eugenol (2.23 mM). On the other hand, creosol, p-cresol, o-cresol, m-cresol, vanillin, and phenol had no effects on fungal development. Logarithm of the octanol/water partition coefficient (log P), refractivity index (RI), and molar volume (MV) were demonstrated to be the descriptors that best explained the antifungal activity correlated to lipophilicity, reactivity of the components, and steric aspect. These findings make an important contribution to the search for new compounds with antifungal activity.
Using Fourier Transform Infrared Spectroscopy to Study Effects of Magnetic Field Treatment on Wheat (Triticum aestivumL.) Seedlings
Authors: Wei Zhenlin , Jiao Dejie , Xu Junxiao
Published: March 2015

Magnetic field treatments have been utilized to promote germination and growth of a variety of species of plants; however the mechanism of concern has not been fully elucidated. In this research, wheat seedlings were treated with 500 mT and 1500 mT static magnetic field (SMF) for 10 and 20 min, respectively. Analyzing Fourier transform infrared spectra collected from leaves of seedlings showed that SMF treatments decreased the contents of lipids and proteins, shifted bands to higher wavenumbers in 3000–2800 cm−1regions, and increased the ratio of CH2/CH3which likely indicates a structural variation of lipids. For bands assigned to different second structures of proteins, slight bands shifting and changing the ratio of different second structures of proteins were observed due to SMF treatments. To summarize, the results revealed that lipids rather than proteins were sensitive to SMF treatments. The results provided insight into the SMF induced conformational changes of lipids and proteins in wheat leaves, which will help elucidate the biological mechanisms of SMF on plant growth and development.
On Unique Continuation for Navier-Stokes Equations
Authors: Duan Zhiwen , Han Shuxia , Sun Peipei
Published: March 2015

We study the unique continuation properties of solutions of the Navier-Stokes equations. We take advantage of rotation transformation of the Navier-Stokes equations to prove the “logarithmic convexity” of certain quantities, which measure the suitable Gaussian decay at infinity to obtain the Gaussian decay weighted estimates, as well as Carleman inequality. As a consequence we obtain sufficient conditions on the behavior of the solution at two different timest0=0andt1=1which guarantee the “global” unique continuation of solutions for the Navier-Stokes equations.
Spatial Mutual Information Based Hyperspectral Band Selection for Classification
Authors: Amankwah Anthony
Published: March 2015

The amount of information involved in hyperspectral imaging is large. Hyperspectral band selection is a popular method for reducing dimensionality. Several information based measures such as mutual information have been proposed to reduce information redundancy among spectral bands. Unfortunately, mutual information does not take into account the spatial dependency between adjacent pixels in images thus reducing its robustness as a similarity measure. In this paper, we propose a new band selection method based on spatial mutual information. As validation criteria, a supervised classification method using support vector machine (SVM) is used. Experimental results of the classification of hyperspectral datasets show that the proposed method can achieve more accurate results.
On Noncompact Fractional Order Differential Inclusions with Generalized Boundary Condition and Impulses in a Banach Space
Authors: Benedetti Irene , Obukhovskii Valeri , Taddei Valentina
Published: March 2015

We provide existence results for a fractional differential inclusion with nonlocal conditions and impulses in a reflexive Banach space. We apply a technique based on weak topology to avoid any kind of compactness assumption on the nonlinear term. As an example we consider a problem in population dynamic described by an integro-partial-differential inclusion.
Total En Bloc Spondylectomy for Locally Aggressive Vertebral Hemangioma Causing Neurological Deficits
Authors: Ogawa Ryo , Hikata Tomohiro , Mikami Shuji , Fujita Nobuyuki , Iwanami Akio , Watanabe Kota , Ishii Ken , Nakamura Masaya , Toyama Yoshiaki , Matsumoto Morio
Published: March 2015

Vertebral hemangiomas are common; however, aggressive vertebral hemangiomas with extraosseous extensions causing neurological deficits are rare. The treatment for this subtype of hemangioma remains controversial, since there are few reports on long-term clinical outcomes or tumor recurrence rates. We describe a case of aggressive vertebral hemangioma treated by total en bloc spondylectomy, with a literature review focusing on long-term recurrence. A 52-year-old male with a two-month history of numbness in the bilateral lower extremities was referred to our hospital. Imaging studies showed a tumor originating in the T9 vertebra and extending to the T8 and T10 vertebrae, with extraosseous extension causing spinal-cord compression. Ten months after onset, the patient presented with progressive paraparesis and hypalgesia. Total en bloc spondylectomy was performed, and pathology was consistent with cavernous hemangioma. Motor and sensory deficits improved significantly, and no signs of recurrence are seen at 2.5 years after operation. A review of literature revealed a recurrence rate of 12.7% (10/79 cases). The available evidence indicates satisfactory long-term outcomes for total tumor resection without adjuvant radiotherapy.
Assessment of Glomerular Filtration Rate Based on Alterations of Serum Brain-Derived Neurotrophic Factor in Type 2 Diabetic Subjects Treated with Amlodipine/Benazepril or Valsartan/Hydrochlorothiazide
Authors: Lee I-Te , Sheu Wayne Huey-Herng , Hung Yi-Jen , Chen Jung-Fu , Wang Chih-Yuan , Lee Wen-Jane
Published: March 2015

Background. Brain-derived neurotrophic factor (BDNF) is associated with sympathetic activation. However, the effects of BDNF on diabetic nephropathy are unknown. The aim of this study was to assess the estimated glomerular filtration rates (eGFRs) and changes in serum BDNF levels in type 2 diabetic subjects treated with antihypertensive medications.Methods. In this randomized, double-blind clinical trial, type 2 diabetic subjects with hypertension were assigned to either the benazepril/amlodipine or valsartan/hydrochlorothiazide treatment groups for a 16-week period. The post hoc analyses were based on increased or decreased serum BDNF levels.Results. Of the 153 enrolled subjects, the changes in eGFR were significantly and inversely correlated with those in BDNF in the 76 subjects treated with valsartan/hydrochlorothiazide (r=-0.264,P=0.021) but not in the 77 subjects treated with benazepril/amlodipine (r=-0.025,P=0.862). The 45 subjects with increased BDNF following valsartan/hydrochlorothiazide treatment exhibited a significantly reduced eGFR (-8.8±14.9 mL/min/1.73 m2;P<0.001). Multivariate regression analysis revealed that increased serum BDNF represents an independent factor for reduced eGFR (95% confidence interval between −0.887 and −0.076,P=0.020).Conclusions. Increased serum BDNF is associated with reduced eGFR in type 2 diabetic subjects treated with valsartan/hydrochlorothiazide but not with amlodipine/benazepril.
Microbiological Quality of Ready-to-Eat Vegetables Collected in Mexico City: Occurrence of Aerobic-Mesophilic Bacteria, Fecal Coliforms, and Potentially Pathogenic Nontuberculous Mycobacteria
Authors: Cerna-Cortes Jorge Francisco , Leon-Montes Nancy , Cortes-Cueto Ana Laura , Salas-Rangel Laura P. , Helguera-Repetto Addy Cecilia , Lopez-Hernandez Daniel , Rivera-Gutierrez Sandra , Fernandez-Rendon Elizabeth , Gonzalez-y-Merchand Jorge Alberto
Published: March 2015

The aims of this study were to evaluate the microbiological quality and the occurrence of nontuberculous mycobacteria (NTM) in a variety of salads and sprouts from supermarkets and street vendors in Mexico City. Aerobic-mesophilic bacteria (AMB) were present in 100% of RTE-salads samples; 59% of samples were outside guidelines range (>5.17 log10CFU per g). Although fecal coliforms (FC) were present in 32% of samples, only 8% of them exceeded the permissible limit (100 MPN/g). Regarding the 100 RTE-sprouts, all samples were also positive for AMB and total coliforms (TC) and 69% for FC. Seven NTM species were recovered from 7 salad samples; they included threeM. fortuitum, twoM. chelonae, oneM. mucogenicum, and oneM. sp.Twelve RTE-sprouts samples harbored NTM, which were identified asM. porcinum(five),M. abscessus(two),M. gordonae(two),M. mucogenicum(two), andM. aviumcomplex (one). Most RTE-salads and RTE-sprouts had unsatisfactory microbiological quality and some harbored NTM associated with illness. No correlation between the presence of coliforms and NTM was found. Overall, these results suggest that RTE-salads and RTE-sprouts might function as vehicles for NTM transmission in humans; hence, proper handling and treatment before consumption of such products might be recommendable.
Two Cases of Primary Cold Agglutinin Disease Associated with Megaloblastic Anemia
Authors: Imashuku Shinsaku , Kudo Naoko , Takagishi Katsushige , Saigo Katsuyasu
Published: March 2015

We report two cases of primary cold agglutinin disease (CAD) associated with megaloblastic anemia in Japanese elderly patients. Case 1 was a 67-year-old male and Case 2 was a 55-year-old male. Both patients were diagnosed with primary CAD, with continuously high cold agglutinin titers (1 : >8,192 and 1 : 16,834, resp.), monoclonal IgM-kappa light chains, and no underlying disease. In addition, both patients had megaloblastic anemia due to vitamin B12 deficiency. One patient received rituximab and both received vitamin 12 supplementation. To date, no cooccurrence of primary CAD and megaloblastic anemia has been emphasized. Thus, the association of these hematological diseases may be incidental; however, given that CAD is an autoimmune disease which may show antibodies against intrinsic factor and gastric parietal cells, this association was thought to be probably not a coincidence. Clinicians should be aware of the possible simultaneous presence of autoimmune hemolytic/megaloblastic anemia in patients with primary CAD.
Stability Evaluation on Surrounding Rocks of Underground Powerhouse Based on Microseismic Monitoring
Authors: Dai Feng , Li Biao , Xu Nuwen , Zhu Yongguo , Xiao Peiwei
Published: March 2015

To study the stability of underground powerhouse at Houziyan hydropower station during excavation, a microseismic monitoring system is adopted. Based on the space-time distribution characteristics of microseismic events during excavation of the main powerhouse, the correlation between microseismic events and blasting construction is established; and the microseismic clustering areas of the underground powerhouse are identified and delineated. The FLAC3D code is used to simulate the deformation of main powerhouse. The simulated deformation characteristics are consistent with that recorded by microseismic monitoring. Finally, the correlation between the macroscopic deformation of surrounding rock mass and microseismic activities is also revealed. The results show that multiple faults between 1# and 3# bus tunnels are activated during excavation of floors V and VI of the main powerhouse. The comprehensive method combining microseismic monitoring with numerical simulation as well as routine monitoring can provide an effective way to evaluate the surrounding rock mass stability of underground caverns.
Dynamic Schedule‐Based Assignment Model for Urban Rail Transit Network with Capacity Constraints
Authors: Han Baoming , Zhou Weiteng , Li Dewei , Yin Haodong
Published: March 2015

There is a great need for estimation of passenger flow temporal and spatial distribution in urban rail transit network. The literature review indicates that passenger flow assignment models considering capacity constraints with overload delay factor for in‐vehicle crowding are limited in schedule‐based network. This paper proposes a stochastic user equilibrium model for solving the assignment problem in a schedule‐based rail transit network with considering capacity constraint. As splitting the origin‐destination demands into the developed schedule expanded network with time‐space paths, the model transformed into a dynamic schedule‐based assignment model. The stochastic user equilibrium conditions can be equivalent to the equilibrium passenger overload delay with crowding penalty in the transit network. The proposal model can estimate the path choice probability according to the equilibrium condition when passengers minimize their perceptive cost in a schedule‐based network. Numerical example in Beijing urban rail transit (BURT) network is used to demonstrate the performance of the model and estimate the passenger flow temporal and spatial distribution more reasonably and dynamically with train capacity constraints.
Multiscale Region‐Level VHR Image Change Detection via Sparse Change Descriptor and Robust Discriminative Dictionary Learning
Authors: Xu Yuan , Ding Kun , Huo Chunlei , Zhong Zisha , Li Haichang , Pan Chunhong
Published: March 2015

Very high resolution (VHR) image change detection is challenging due to the low discriminative ability of change feature and the difficulty of change decision in utilizing the multilevel contextual information. Most change feature extraction techniques put emphasis on the change degree description (i.e., in what degree the changes have happened), while they ignore the change pattern description (i.e., how the changes changed), which is of equal importance in characterizing the change signatures. Moreover, the simultaneous consideration of the classification robust to the registration noise and the multiscale region‐consistent fusion is often neglected in change decision. To overcome such drawbacks, in this paper, a novel VHR image change detection method is proposed based on sparse change descriptor and robust discriminative dictionary learning. Sparse change descriptor combines the change degree component and the change pattern component, which are encoded by the sparse representation error and the morphological profile feature, respectively. Robust change decision is conducted by multiscale region‐consistent fusion, which is implemented by the superpixel‐level cosparse representation with robust discriminative dictionary and the conditional random field model. Experimental results confirm the effectiveness of the proposed change detection technique.
Influence of the Saturation Ratio on Concrete Behavior under Triaxial Compressive Loading
Authors: Vu Xuan-Dung , Briffaut Matthieu , Malecot Yann , Daudeville Laurent , Ciree Bertrand
Published: March 2015

When a concrete structure is subjected to an impact, the material is subjected to high triaxial compressive stresses. Furthermore, the water saturation ratio in massive concrete structures may reach nearly 100% at the core, whereas the material dries quickly on the skin. The impact response of a massive concrete wall may thus depend on the state of water saturation in the material. This paper presents some triaxial tests performed at a maximum confining pressure of 600 MPa on concrete representative of a nuclear power plant containment building. Experimental results show the concrete constitutive behavior and its dependence on the water saturation ratio. It is observed that as the degree of saturation increases, a decrease in the volumetric strains as well as in the shear strength is observed. The coupled PRM constitutive model does not accurately reproduce the response of concrete specimens observed during the test. The differences between experimental and numerical results can be explained by both the influence of the saturation state of concrete and the effect of deviatoric stresses, which are not accurately taken into account. The PRM model was modified in order to improve the numerical prediction of concrete behavior under high stresses at various saturation states.
Pharmacological Inhibition of KIT Activates MET Signaling in Gastrointestinal Stromal Tumors
Authors: Cohen Noah A. , Zeng Shan , Seifert Adrian M. , Kim Teresa S. , Sorenson Eric C. , Greer Jonathan B. , Beckman Michael J. , Santamaria-Barria Juan A. , Crawley Megan H. , Green Benjamin L. , Rossi Ferdinand , Besmer Peter , Antonescu Cristina R. , DeMatteo Ronald P.
Published: April 2015

Gastrointestinal stromal tumors (GIST) are the most common adult sarcomas and the oncogenic driver is usually a KIT or PDGFRA mutation. Although GISTs are often initially sensitive to imatinib or other tyrosine kinase inhibitors, resistance generally develops, necessitating backup strategies for therapy. In this study, we determined that a subset of human GIST specimens that acquired imatinib resistance acquired expression of activated forms of the MET oncogene. MET activation also developed after imatinib therapy in a mouse model of GIST (KitV558del/+ mice), where it was associated with increased tumor hypoxia. MET activation also occurred in imatinib-sensitive human GIST cell lines after imatinib treatment in vitro. MET inhibition by crizotinib or RNA interference was cytotoxic to an imatinib-resistant human GIST cell population. Moreover, combining crizotinib and imatinib was more effective than imatinib alone in imatinib-sensitive GIST models. Finally, cabozantinib, a dual MET and KIT small-molecule inhibitor, was markedly more effective than imatinib in multiple preclinical models of imatinib-sensitive and imatinib-resistant GIST. Collectively, our findings showed that activation of compensatory MET signaling by KIT inhibition may contribute to tumor resistance. Furthermore, our work offered a preclinical proof of concept for MET inhibition by cabozantinib as an effective strategy for GIST treatment. Cancer Res; 75(10); 2061–70. ©2015 AACR.
Risk Analysis of Prostate Cancer in PRACTICAL, a Multinational Consortium, Using 25 Known Prostate Cancer Susceptibility Loci
Authors: Amin Al Olama Ali , Benlloch Sara , Antoniou Antonis C. , Giles Graham G. , Severi Gianluca , Neal David E. , Hamdy Freddie C. , Donovan Jenny L. , Muir Kenneth , Schleutker Johanna , Henderson Brian E. , Haiman Christopher A. , Schumacher Fredrick R. , Pashayan Nora , Pharoah Paul D.P. , Ostrander Elaine A. , Stanford Janet L. , Batra Jyotsna , Clements Judith A. , Chambers Suzanne K. , Weischer Maren , Nordestgaard Børge G. , Ingles Sue A. , Sorensen Karina D. , Orntoft Torben F. , Park Jong Y. , Cybulski Cezary , Maier Christiane , Doerk Thilo , Dickinson Joanne L. , Cannon-Albright Lisa , Brenner Hermann , Rebbeck Timothy R. , Zeigler-Johnson Charnita , Habuchi Tomonori , Thibodeau Stephen N. , Cooney Kathleen A. , Chappuis Pierre O. , Hutter Pierre , Kaneva Radka P. , Foulkes William D. , Zeegers Maurice P. , Lu Yong-Jie , Zhang Hong-Wei , Stephenson Robert , Cox Angela , Southey Melissa C. , Spurdle Amanda B. , FitzGerald Liesel , Leongamornlert Daniel , Saunders Edward , Tymrakiewicz Malgorzata , Guy Michelle , Dadaev Tokhir , Little Sarah J. , Govindasami Koveela , Sawyer Emma , Wilkinson Rosemary , Herkommer Kathleen , Hopper John L. , Lophatonanon Aritaya , Rinckleb Antje E. , Kote-Jarai Zsofia , Eeles Rosalind A. , Easton Douglas F.
Published: April 2015

Background: Genome-wide association studies have identified multiple genetic variants associated with prostate cancer risk which explain a substantial proportion of familial relative risk. These variants can be used to stratify individuals by their risk of prostate cancer.

Methods: We genotyped 25 prostate cancer susceptibility loci in 40,414 individuals and derived a polygenic risk score (PRS). We estimated empirical odds ratios (OR) for prostate cancer associated with different risk strata defined by PRS and derived age-specific absolute risks of developing prostate cancer by PRS stratum and family history.

Results: The prostate cancer risk for men in the top 1% of the PRS distribution was 30.6 (95% CI, 16.4–57.3) fold compared with men in the bottom 1%, and 4.2 (95% CI, 3.2–5.5) fold compared with the median risk. The absolute risk of prostate cancer by age of 85 years was 65.8% for a man with family history in the top 1% of the PRS distribution, compared with 3.7% for a man in the bottom 1%. The PRS was only weakly correlated with serum PSA level (correlation = 0.09).

Conclusions: Risk profiling can identify men at substantially increased or reduced risk of prostate cancer. The effect size, measured by OR per unit PRS, was higher in men at younger ages and in men with family history of prostate cancer. Incorporating additional newly identified loci into a PRS should improve the predictive value of risk profiles.

Impact: We demonstrate that the risk profiling based on SNPs can identify men at substantially increased or reduced risk that could have useful implications for targeted prevention and screening programs. Cancer Epidemiol Biomarkers Prev; 24(7); 1121–9. ©2015 AACR.
Improving the Quality of Biomarker Discovery Research: The Right Samples and Enough of Them
Authors: Pepe Margaret S. , Li Christopher I. , Feng Ziding
Published: April 2015

Background: Biomarker discovery research has yielded few biomarkers that validate for clinical use. A contributing factor may be poor study designs.

Methods: The goal in discovery research is to identify a subset of potentially useful markers from a large set of candidates assayed on case and control samples. We recommend the PRoBE design for selecting samples. We propose sample size calculations that require specifying: (i) a definition for biomarker performance; (ii) the proportion of useful markers the study should identify (Discovery Power); and (iii) the tolerable number of useless markers amongst those identified (False Leads Expected, FLE).

Results: We apply the methodology to a study of 9,000 candidate biomarkers for risk of colon cancer recurrence where a useful biomarker has positive predictive value ≥ 30%. We find that 40 patients with recurrence and 160 without recurrence suffice to filter out 98% of useless markers (2% FLE) while identifying 95% of useful biomarkers (95% Discovery Power). Alternative methods for sample size calculation required more assumptions.

Conclusions: Biomarker discovery research should utilize quality biospecimen repositories and include sample sizes that enable markers meeting prespecified performance characteristics for well-defined clinical applications to be identified.

Impact: The scientific rigor of discovery research should be improved. Cancer Epidemiol Biomarkers Prev; 24(6); 944–50. ©2015 AACR.
Upregulation of Periostin and Reactive Stroma Is Associated with Primary Chemoresistance and Predicts Clinical Outcomes in Epithelial Ovarian Cancer
Authors: Ryner Lisa , Guan Yinghui , Firestein Ron , Xiao Yuanyuan , Choi Younjeong , Rabe Christina , Lu Shan , Fuentes Eloisa , Huw Ling-Yuh , Lackner Mark R. , Fu Ling , Amler Lukas C. , Bais Carlos , Wang Yulei
Published: April 2015

Purpose: Up to one third of ovarian cancer patients are intrinsically resistant to platinum-based treatment. However, predictive and therapeutic strategies are lacking due to a poor understanding of the underlying molecular mechanisms. This study aimed to identify key molecular characteristics that are associated with primary chemoresistance in epithelial ovarian cancers.

Experimental Design: Gene expression profiling was performed on a discovery set of 85 ovarian tumors with clinically well-defined response to chemotherapies as well as on an independent validation dataset containing 138 ovarian patients from the chemotreatment arm of the ICON7 trial.

Results: We identified a distinct “reactive stroma” gene signature that is specifically associated with primary chemoresistant tumors and was further upregulated in posttreatment recurrent tumors. Immunohistochemistry (IHC) and RNA in situ hybridization (RNA ISH) analyses on three of the highest-ranked signature genes (POSTN, LOX, and FAP) confirmed that modulation of the reactive stroma signature genes within the peritumoral stromal compartments was specifically associated with the clinical chemoresistance. Consistent with these findings, chemosensitive ovarian cells grown in the presence of recombinant POSTN promoted resistance to carboplatin and paclitaxel treatment in vitro. Finally, we validated the reactive stroma signature in an independent dataset and demonstrated that a high POSTN expression level predicts shorter progression-free survival following first-line chemotherapy.

Conclusions: Our findings highlight the important interplay between cancer and the tumor microenvironment in ovarian cancer biology and treatment. The identified reactive stromal components in this study provide a molecular basis to the further development of novel diagnostic and therapeutic strategies for overcoming chemoresistance in ovarian cancer. Clin Cancer Res; 21(13); 2941–51. ©2015 AACR.
Impacto da implantação de um novo modelo de gestão embasado em indicadores no bloco cirúrgico de um hospital universitário
Authors: Gaspar Alberto Facury , Martone Daniel , Carraro Denise Cristina , Ferreira Gabriela Souza Assis , Ferreira-Filho João Almiro , Cardoso Roberto , Pazin-Filho Antonio
Published: March 2015

O centro cirúrgico, por suas particularidades e características, constitui uma das unidades mais complexas do ambiente hospitalar. Assim, percebe-se que o bom desempenho de um centro cirúrgico está diretamente relacionado com a qualidade de seus próprios processos e com os processos dos serviços que o apoiam. Em Julho de 2012, com a portaria 194 – HCRP (5), é estabelecido as Diretrizes Gerais de Funcionamento do Bloco Cirúrgico do HC campus. O objetivo do presente estudo é avaliar o impacto do novo modelo gerencial do Bloco Cirúrgico do Campus implantado. Trata-se de séria histórica descritiva e retrospectiva com análise de alguns indicadores comparando a nova gestão com a fase prévia. Nota-se melhora progressiva em alguns indicadores analisados, alcançando metas estipuladas pelo pró- prio Planejamento estratégico vigente. O presente estudo pode ilustrar o impacto de um modelo gerencial dentro do Centro Cirúrgico de um Hospital Escola Terciário de grande porte, mostrando os avanços alcançados e os pontos com oportunidades de melhoria.
Análise do impacto orçamentário causado pela implantação de assinatura digital no Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo
Authors: Pellison Felipe Carvalho , Carneiro Alexandre , Namburete Eva , Sant’Ana Fabio , Lívia Lívia , Pereira Marcos Roberto , Tavares Tabata , Pazin-Filho Antônio
Published: March 2015

Com o processo de inovação tecnológica, avanço de redes e softwares, surgem novas formas de catalogação de dados e documentos. No setor de saúde isso corrobora com a melhora do serviço prestado, já que o aumento da demanda requer segurança, rapidez e economia. Este trabalho foi realizado no Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto USP (HCFMRP USP), um hospital terciário que atua na assistência, ensino e pesquisa. Este trabalho tem como objetivo analisar o impacto orçamentário da aquisição e renovação do certificado digital pelo HCFMRP USP com uma análise direta do custo de impressão e aquisição de papel. Para o cálculo do tempo de retorno financeiro utilizou-se o Payback descontado. Verificou-se que o valor investido na aquisição do registro digital será totalmente revertido em aproximadamente menos de um ano, concluindo-se que esta migração é vantajosa em termos econômicos. A economia alcançada com este recurso proporcionará maior capacidade de investimento do hospital em outras áreas
Short-Term Intravenous Sodium Nitrite Infusion Improves Cardiac and Pulmonary Hemodynamics in Heart Failure Patients
Authors: Ormerod Julian O.M. , Arif Sayqa , Mukadam Majid , Evans Jonathan D.W. , Beadle Roger , Fernandez Bernadette O. , Bonser Robert S. , Feelisch Martin , Madhani Melanie , Frenneaux Michael P.
Published: April 2015

Background—

Nitrite exhibits hypoxia-dependent vasodilator properties, selectively dilating capacitance vessels in healthy subjects. Unlike organic nitrates, it seems not to be subject to the development of tolerance. Currently, therapeutic options for decompensated heart failure (HF) are limited. We hypothesized that by preferentially dilating systemic capacitance and pulmonary resistance vessels although only marginally dilating resistance vessels, sodium nitrite (NaNO
2
) infusion would increase cardiac output but reduce systemic arterial blood pressure only modestly. We therefore undertook a first-in-human HF proof of concept/safety study, evaluating the hemodynamic effects of short-term NaNO
2
infusion.

Methods and Results—

Twenty-five patients with severe chronic HF were recruited. Eight received short-term (5 minutes) intravenous NaNO
2
at 10 μg/kg/min and 17 received 50 μg/kg/min with measurement of cardiac hemodynamics. During infusion of 50 μg/kg/min, left ventricular stroke volume increased (from 43.22±21.5 to 51.84±23.6 mL;
P
=0.003), with marked falls in pulmonary vascular resistance (by 29%;
P
=0.03) and right atrial pressure (by 40%;
P
=0.007), but with only modest falls in mean arterial blood pressure (by 4 mm Hg;
P
=0.004). The increase in stroke volume correlated with the increase in estimated trans-septal gradient (=pulmonary capillary wedge pressure–right atrial pressure;
r
=0.67;
P
=0.003), suggesting relief of diastolic ventricular interaction as a contributory mechanism. Directionally similar effects were observed for the above hemodynamic parameters with 10 μg/kg/min; this was significant only for stroke volume, not for other parameters.

Conclusions—

This first-in-human HF efficacy/safety study demonstrates an attractive profile during short-term systemic NaNO
2
infusion that may be beneficial in decompensated HF and warrants further evaluation with longer infusion regimens.
Revision of the Neotropical subgenera Coelioxys (Platycoelioxys) Mitchell and C. (Rhinocoelioxys) Mitchell (Hymenoptera; Megachilidae) with the description of one new species
Authors: FILHO LÉO CORREIA DA ROCHA , PACKER LAURENCE
Published: March 2015

Two Neotropical subgenera of Coelioxys Latreille are revised. The monotypic C. (Platycoelioxys) Mitchell and C. (Rhinocoelioxys) Mitchell has seven valid species; six of them (C. agilis Smith, C. barbata Schwarz & Michener, C. clypearis Friese, C. nasidens Friese, C. paraguayensis Schrottky and C. zapoteca Cresson) previously described, and one, C. platygnatha Rocha-Filho & Packer n. sp. is new from Amazonas State, Brazil. Coelioxys nasidens, previously considered a junior synonym of C. clypeata Smith, is resurrected. Coelioxys crassiceps Friese and C. excisa Friese are synonymized under C. agilis, and C. rostrata Friese is synonymized under C. paraguayensis. Nine names (C. clypeata, C. leucochrysea Cockerell, C. angustivalva Holmberg, C. doelloi Holmberg, C. blabera Holmberg, C. mesopotamica Holmberg, C. bilobata Friese, C. bilobata schenki Friese and C. bullaticeps Friese) are synonymized with C. zapoteca. In the latter species the shape of the apical margin of the clypeus of the female varies widely and, though intermediates occur among all forms, the DNA barcode sequences for the different forms are very similar. One species formerly considered as incertae sedis, C. clypearis, and one belonging to the subgenus C. (Cyrtocoelioxys) Mitchell, C. barbata, are both assigned to the subgenus C. (Rhinocoelioxys). Keys for both sexes of C. (Rhinocoelioxys), distribution maps, host and floral records, redescriptions of species and the description of a new species are provided. In the subgenus C. (Platycoelioxys), only one species, C. alatiformis Friese, is recognized with two junior synonyms: C. crassiceps Friese syn. nov. and C. spatuliventer Cockerell.
Compositermes bani sp.n. (Isoptera, Termitidae, Apicotermitinae), a new species of soldierless termite from Bolivia
Authors: CARRIJO TIAGO F. , SCHEFFRAHN RUDOLF H. , KŘEČEK JAN
Published: March 2015

Species of neotropical Apicotermitinae (Termitidae) are soldierless, restricting species identification in this group to workers or seasonally present winged imagos. All neotropical Apicotermitinae were placed in the genus Anoplotermes, until Mathews (1977) described two new genera, Grigiotermes and Ruptitermes. Fontes (1986) described two more genera, Aparatermes and Tetimatermes. Twenty years passed without any taxonomic advances in this group until Scheffrahn et al. 2006 described two new Anoplotermes species from the West Indies and Bourguignon et al. 2010 described Longustitermes manni, (=Anoplotermes manni Snyder), Anoplotermes janus, and placed six other species into synonymy. Finally, Scheffrahn 2013 described a new genus and species, Compositermes vindai, characterized by a ring of sclerotized paddles at the junction of the enteric valve seating (EVS) and paunch (P3).
First record of the genus Neostatherotis Oku from China, with the descriptions of four new species (Lepidoptera: Tortricidae: Olethreutinae)
Authors: LUO JIUYANG , FEI YAO , YU HAILI
Published: March 2015

The tortricid genus Neostatherotis Oku, 1974 is newly reported from China, and four species are described as new: N. psilata, sp. nov., N. sparsula, sp. nov., N. angustata, sp. nov., and N. breviuscula, sp. nov. Morphological descriptions and illustrations are provided, and a key for identification of the Chinese species is given.
A new species of soft-winged flower beetles of the genus Kuatunia Evers, 1945–48 (Coleoptera, Cleroidea, Malachiidae) from Nepal
Authors: TSHERNYSHEV SERGEI E.
Published: March 2015

A new malachiid species of the genus Kuatunia Evers is described: K. matthiasi sp. n., from Nepal, Seti Province; figures of male habitus, elytral appendices, genitalia, and a distribution map are presented. A determination key to all species of Kuatunia is also proposed.
Revision of the bryozoan genus Gephyrotes Norman, 1903 (Cheilostomata, Cribrilinidae) with the description of two new taxa
Authors: MARTINO EMANUELA DI , ROSSO ANTONIETTA
Published: March 2015

The finding of a new species of Gephyrotes, G. moissettei n. sp., in Miocene deposits of southern Italy, prompted a revision of this distinctive cribrimorph taxon, leading to the redescription and first SEM documentation of the type material of nine species. Five of them are retained in Gephyrotes, namely the type species, G. nitidopunctatus, and G. fortunensis, G. spectabilis, G. quadriserialis, and G. convexus, to which G. moissettei n. sp. is added. The only Recent species is the genotype, while all the others are fossils from North America, Europe and northwest Africa. Two further species are transferred to the genus Tricephalopora, namely T. saillans and T. levigata, whereas Spiniflabellum n. gen., is established to accommodate a species from the Caribbean area, S. spinosum, previously assigned to Gephyrotes.
A new species of the Choroterpes Eaton, 1881 subgenus Monophyllus Kluge, 2012 and a new record of the subgenus Choroterpes, s.s. (Ephemeroptera: Leptophlebiidae) from southern Western Ghats, India
Authors: SELVAKUMAR C. , JANARTHANAN S. , SIVARAMAKRISHNAN K. G.
Published: March 2015

A new species of Choroterpes (Monophyllus) is described based on larvae collected from rivers of Karnataka part of the Western Ghats. Choroterpes (Monophyllus) nandini n. sp. can be distinguished from the only other species viz., C. (Monophyllus) monophyllus by the following combination of characters: (i) median emargination of labrum moderately deep, without denticles; (ii) gills 2–7 without tracheation and (iii) abdominal segment 6 and 7 without colour pattern. Choroterpes (Choroterpes) petersi Tong and Dudgeon 2003 is newly recorded based on larval collections from the eastern and western regions of southern Western Ghats.
A new species of soft-winged flower beetles of the genus Platyebaeus Wittmer, 1995 (Coleoptera, Cleroidea, Malachiidae) from Philippines
Authors: TSHERNYSHEV SERGEI E.
Published: March 2015

A new malachiid species of the genus Platyebaeus Wittmer is described: P. quirinicus sp. n., from the Sierra Madre mountain range in Quirino province, Luzon Island, Philippines. Figures of male habitus, elytral apical third profile, genitalia, and a map showing the type locality are given for the new species. A determination key to the 3 species belonging to Platyebaeus is also provided.
Children's Cancer Camps
Authors: Laing Catherine M. , Moules Nancy J.
Published: March 2015

A philosophical hermeneutic study was conducted as part of the first author's doctoral research to understand the meaning of children's cancer camps for the child with cancer and the family. Twenty family members from six families were interviewed in order to bring understanding to this topic. This article will detail the finding related to the experience of grief that often accompanies a cancer diagnosis, and how camp seems to allow children and families to understand their grief differently. The interesting thing about this particular cancer camp is that families of children who have died continue to attend the camp yearly, and there are events to memorialize the many children known to all the campers who no longer attend camp. This is not a grief camp but a cancer camp where grief is allowed presence as it necessarily has to in the world of childhood cancer.
Cannibalism
Authors: Lester David , White John , Giordano Brandi
Published: March 2015

A dataset of 73 variables was complied on 345 serial killers, 31 of whom who engaged in cannibalism. A distinction was made between those who engaged only in cannibalism, those who engaged in necrophilia, and those who engaged in both or neither. Those who engaged in both cannibalism and necrophilia were the most psychiatrically disturbed and deviant, but those who engaged in only cannibalism were more disturbed and deviant in their actions than those who engaged in neither behavior.
Faecolith migrating from the appendix to produce liver abscess after subhepatic laparoscopic appendectomy
Authors: Kumar Devendra , Ramanathan Subramaniyan , Faki Ahmad Al , Nepal Pankaj
Published: March 2015

The subhepatic position of an appendix may lead to difficulty in diagnosis of appendicitis, its surgical management as well as bizarre complications. A ‘lost’ appendicular faecolith is not an uncommon complication due to spillage during the removal of the appendix or due to perforation. Here we report a case of such a faecolith migrating into the liver parenchyma following intraoperative hepatic injury, and producing a liver abscess. The calcified lesion seen in the liver corresponded to a free-lying faecolith on a preoperative computed tomography scan. Liver abscess was presumed to arise from implantation of this foreign object into the liver parenchyma. Pigtail drainage of abscess was performed with good result.
A Communication-Based Approach to Adoptive Identity: Theoretical and Empirical Support
Authors: Colaner Colleen Warner , Soliz Jordan
Published: March 2015

The current study uses structural equation modeling to examine adoptive parent communication as it relates to adoptee adjustment directly and indirectly through adoptive identity. Using retrospective accounts of 179 adult adoptees, findings indicate that both adoption- (adoption communication openness) and non-adoption-related (parental confirmation and affectionate communication) parental communication are related to adoptive identity work and positive affect about adoption and birth parents. Preoccupation mediates the relationship between parental communication and adoptee adjustment. The current study integrates research and theorizing from identity, adoption, and communication literatures to develop a communication-centered conceptual model of adoptive identity development to inform future adoption research and practice.
From Praise to Condemnation
Authors: Basa Inci
Published: April 2015

This article observes how architectural practice and symbolic appropriations interconnectedly produced space in 1920s’ Ankara, the new capital of the new Republic of Turkey. The once magnificent and powerful Istanbul, capital of the Ottoman Empire, had its centuries long authority removed to disassociate the country from corporeal memories of its Ottoman past. The old capital was associated both with imperial and Islamic characteristics, and the republicans aimed to build a capital that spatially represented modernity. Interestingly, however, they employed Ottoman Revivalism, the architectural style in vogue at the time, to embody the political power of the new republic. This article emphasizes the contradiction between the “retrospective” politics of Ottoman Revivalism and the “modernist” vision of the republicans. It explores the sudden collapse of the revivalist approach by tracing the trajectory of modernist discourse as it was influenced by the political dynamics of the time.
Weighing in on the Body Knowledge Questionnaire
Authors: Hernandez David A. , Hernandez Cheri Ann
Published: April 2015

Purpose

The purpose of this research was to develop and pilot test the Body Knowledge Questionnaire (BKQ), an instrument that measures weight management integration, and to determine its reliability and validit.y

Methods

The 27 items of the BKQ were developed through review of the literature on integration and weight management/obesity. The resulting BKQ was pilot tested with 4 groups of individuals with and without type 2 diabetes. Exploratory factor analysis was used to assess the construct validity of the BKQ, and discriminant function analysis and logistic regression were used to establish criterion-related validity. Scale reliability analysis was used to determine the internal consistency of the BKQ and its subscales.

Results

Exploratory factor analysis yielded a 2-factor solution, with factor loadings that were fair to excellent (.45-.81). Discriminant function analysis determined that the BKQ subscales could accurately predict the classification of participants into normal- and obese-weight groups. Results of the logistic regression showed that the BKQ could reliably distinguish between normal- and obese-weight participants. Internal consistency of the overall BKQ was .87, .89, and .73 for the subscales, Food Centricity and Psychosomatic Awareness.

Conclusions

This research provided preliminary evidence of the validity (content, construct, and criterion) and reliability (internal consistency) of the BKQ. With additional psychometric testing, the BKQ instrument has great potential for use in weight management practice areas, such as diabetes education, dietetics, nursing, and psychology, for use in individual or group weight management programs and program evaluation; or in the development of novel weight management interventions.
Translating Science to Benefit Diverse Publics
Authors: Leith Peat , Vanclay Frank
Published: March 2015

We argue that for scientists and science communicators to build usable knowledge for various publics, they require social and political capital, skills in boundary work, and ethical acuity. Drawing on the context of communicating seasonal climate predictions to farmers in Australia, we detail four key issues that scientists and science communicators would do well to reflect upon in order to become effective and ethical intermediaries. These issues relate to (1) the boundary work used to link science and values and thereby construct public identities, (2) emplacement, that is, the importance of situating knowledge in relation to the places with which people identify, (3) personal and organizational processes of reflexivity, and (4) the challenges of developing and maintaining the social and political capital necessary to simultaneously represent people’s identities and lifeworlds and the climate systems that affect them. Through a discourse analysis of in-depth interviews with Australian agro-climatologists, we suggest that three distinct “modes of extension” are apparent, namely, discursive, conceptual, and contextual. Our participants used these three modes interdependently to create knowledge that has salience, credibility, and legitimacy. They thereby generated new narratives of place, practice, and identity for Australian agriculture.
Cone beam computed tomography images fusion in predicting lung ablation volumes: a feasibility study
Authors: Ierardi Anna Maria , Petrillo Mario , Xhepa Genti , Laganà Domenico , Piacentino Filippo , Floridi Chiara , Duka Ejona , Fugazzola Carlo , Carrafiello Gianpaolo
Published: March 2015

Background

Recently different software with the ability to plan ablation volumes have been developed in order to minimize the number of attempts of positioning electrodes and to improve a safe overall tumor coverage.

Purpose

To assess the feasibility of three-dimensional cone beam computed tomography (3D CBCT) fusion imaging with “virtual probe” positioning, to predict ablation volume in lung tumors treated percutaneously.

Material and Methods

Pre-procedural computed tomography contrast-enhanced scans (CECT) were merged with a CBCT volume obtained to plan the ablation. An offline tumor segmentation was performed to determine the number of antennae and their positioning within the tumor. The volume of ablation obtained, evaluated on CECT performed after 1 month, was compared with the pre-procedural predicted one. Feasibility was assessed on the basis of accuracy evaluation (visual evaluation [VE] and quantitative evaluation [QE]), technical success (TS), and technical effectiveness (TE).

Results

Seven of the patients with lung tumor treated by percutaneous thermal ablation were selected and treated on the basis of the 3D CBCT fusion imaging. In all cases the volume of ablation predicted was in accordance with that obtained. The difference in volume between predicted ablation volumes and obtained ones on CECT at 1 month was 1.8 cm3 (SD ± 2, min. 0.4, max. 0.9) for MW and 0.9 cm3 (SD ± 1.1, min. 0.1, max. 0.7) for RF.

Conclusion

Use of pre-procedural 3D CBCT fusion imaging could be useful to define expected ablation volumes. However, more patients are needed to ensure stronger evidence.
Fatigue property in paper-based friction materials under out-of-plane compressive loading
Authors: Fujii Tomoyuki , Tohgo Keiichiro , Urata Naoya , Shimamura Yoshinobu , Hasegawa Tomohiro , Yagi Shintaro , Ito Yoichi
Published: March 2015

This paper deals with fatigue behavior of paper-based friction materials under cyclic compression to tension loading and damage behavior under cyclic compressive loading. The fatigue tests under out-of-plane compressive stress to slight tensile stress loading are conducted to evaluate fatigue strength of friction materials. The tests under cyclic out-of-plane compressive loading are also conducted to investigate influence of compressive stress and load cycles on damage behavior. Two kinds of friction materials are composed of aramid-based fiber and phenolic resin, and cellulose fiber and phenolic resin. Their fatigue strengths decrease with increasing load cycles. The damage density in both materials increases with increasing compressive stress and load cycles.