bluuebunny/crossref_metadata_2025 huggingface dataset:
Logika: Seni Berpikir Lurus
Authors: Dewantara Agustinus
Published: October 2019

“Man by nature have desire to know.” Demikianlah Aristoteles membuka traktat filsafatnya. Manusia selalu ingin serba tahu ini oleh Aristoteles dibahasakan dengan selalu memiliki “have desire to know”, dan ini pun “by nature.” Hal ini terjadi karena manusia memang dianugerahi akal budi yang selalu menuntut kepuasan akal budi. Bukan suatu kesombongan, akan tetapi lebih merupakan suatu kejujuran dalam menghayati kemanusiaannya secara lebih penuh dari hari ke hari. Pengetahuan yang digagas pun bukan sembarang pengetahuan. Manusia sadar bahwa ia dianugerahi akal budi yang harus dipergunakan dengan baik. Selain itu perlulah juga suatu piranti dalam menjaga keketatan pemikiran agar tidak jatuh ke dalam kesalahan. Dan itulah logika. Logika dengan demikian menjadi elemen yang tidak dapat dipisahkan dari usaha manusia untuk mencari kebenaran, hingga nanti sampailah ia kepada Sang Kebenaran Tertinggi, yakni Allah sendiri. Semoga buku ini bermanfaat.
The Open-Factor: Toward impact-aligned measures of open-access ebook usage
Authors: Hellman Eric
Published: October 2019

A statistical analysis of usage data for open-access ebooks from two different publishers and from a free ebook distribution platform indicates that open-access ebook usage is distributed following log-normal statistics, and meaningful analysis results after calculating the logarithm of the download counts. To assess usage impact from raw usage data in alignment with the goals of open-access ebook publishing, future impact analyses should use logarithm-based metrics to measure an “open-factor”.
Strategies that reduce Stroop interference
Authors: Palfi Bence , Parris Ben , Collins Anthony , Dienes Zoltan
Published: October 2019

A remarkable example of reducing Stroop interference is provided by the word blindness post-hypnotic suggestion (a suggestion to see words as meaningless during the Stroop task). This suggestion has been repeatedly demonstrated to halve Stroop interference when it is given to highly hypnotisable individuals. In order to explore how highly hypnotisable people manage to reduce Stroop interference when they respond to the word blindness suggestion, we tested four candidate strategies in two experiments outside of the hypnotic context. A strategy of looking-away from the target words, and a strategy of visual blurring demonstrated compelling evidence for substantially reducing Stroop interference in both experiments. However, the pattern of results produced by these strategies did not match those of the word blindness suggestion. Crucially, neither looking-away nor visual blurring managed to speed up incongruent responses, suggesting that neither of these strategies are likely underlying mechanisms of the word blindness suggestion. Although the current results did not unravel the mystery of the word blindness suggestion, they showed that there are multiple voluntary ways through which participants can dramatically reduce Stroop interference.
A gradient approach to flexible constituent order
Authors: Namboodiripad Savithry
Published: October 2019

Languages are known to differ in how many orderings of major constituents are grammatical, as well as how interchangeable these orders are, a property often referred to as flexibility. Due to a variety of factors, including methodological barriers, flexibility is often underdescribed or treated as categorically, with languages being placed into heterogenous bins such as “free” or “rigid”. This paper advocates for starting from the premise that languages differ in degree and not kind when it comes to flexibility, presents a novel method for measuring flexibility in constituent order (via acceptability judgment experiments), and applies this approach to two languages which are known to differ in flexibility: English (Experiment 1) and Malayalam (Experiment 2). Flexibility is operationally defined as the difference in acceptability between canonical and non-canonical orders. Experiment 1 demonstrates that acceptability experiments can distinguish between canonical (svo), non-canonical (osv), and ungrammatical orders in English. For Malayalam, in which all orders of subject, object, and verb are grammatical and attested, verb-final orders group together and are most acceptable, followed by verb-medial and then verb-initial orders; this provides an initial picture of non-verb-final orders, which have been under-theorized in this language. Finally, a qualitative comparison of each language’s constituent order profile (a plot of the acceptability of each order in a language) serves as proof-of-concept that this measure allows for meaningful comparison across languages. This approach serves to en- rich typological descriptions of constituent order across languages, and it opens up opportunities for testing hypotheses about the source(s) of flexibility.
Menyelaraskan Fiqih Mu’āmalāt dan Literasi Finansial
Authors: Setiawan Adib Rifqi
Published: October 2019

Abū Bakr ‘Utsman ibn Muḥammad al-Dimyāṭī melalui I'ānatu al-Ṭōlibīna menyampaikan bahwa pembahasan mu’āmalāt dilakukan setelah ‘ibādāt dan sebelum topik lain dalam Fiqh karena kebutuhan manusia terhadap transaksi ekonomi adalah hal yang sangat penting. Dari sini tampak bahwa Fiqh memiliki perhatian terhadap masalah ekonomi. Perhatian Fiqh tersebut diwujudkan dalam bentuk memberi prinsip dasar, teori hukum, dan larangan umum yang mendasari praktik mu'āmalāt. Perhatian dari Fiqh tersebut selaras dengan saran OECD (Organisasi Kerja Sama dan Pembangunan Ekonomi) yang menyampaikan lebih khusus bahwa pendidikan tentang masalah keuangan harus sedini mungkin dimulai di sekolah yang notabene tahap awal kehidupan pelajar. Bedanya saran OECD tidak disertai penyediaan prinsip dasar, teori hukum, dan larangan umum seperti Fiqh, tapi saran tersebut berperan dalam pengembangan kerangka kerja Literasi Finansial. Artikel ini bertujuan untuk mengurai kaitan antara Fiqh Mu'āmalāt dan Literasi Finansial sebagai kerangka kerja pendidikan untuk pendidikan menengah. Secara khusus, kerangka kerja ini diarahkan agar dapat diterapkan dalam kegiatan pembelajaran di Pondok Pesantren sebagai lembaga pendidikan yang mendidik keterampilan hidup berdasarkan kajian keislaman.
Early Experience of Microsurgical Clipping of Ruptured Intracranial Aneurysms
Authors: Nepal Pankaj Raj
Published: October 2019

To see the outcome in patients following microsurgical clipping of ruptured intracranial aneurysms and analyze the results. It is a prospective analytical study were demographic data of the patient, initial World Federation of Neurosurgical Societies (WFNS) grade, Fischer’s grade, duration of ictus, intra operative rupture, incidence of clinical vasospasm and Modified Rankin Scale (MRS) at three months were collected and analysis was done using SPSS-20. There were total 19 cases of microsurgical clipping, with mean age 55.4 yrs, where 52.4% were females. Average duration of Ictus was 24.5 hours. Most common WFNS grade on presentation was grade II (42%) and Fischer’s CT grade was IV (58%). Commonest site of aneurysm was A Com (53%) and were 15.8% intraoperatie rupture. Ventriculo-peritoneal (VP) shunt and severe clinical vasospasm both were seen in 10.5%. Overall mortality was 11% and MRS 1 and 2 were obtained in 10% and 58% respectively. Good initial WFNS, internal carotid aneurysm, absence of hydrocephalus and absence of clinical vasospasm were significantly associated with better MRS at three months. Factors associated with better outcome were good initial WFNS, internal carotid aneurysm, absence of hydrocephalus and absence of clinical vasospasm.
Outcome of Early versus Late Tracheostomy in Neurosurgical critical Patient
Authors: Neupane Bal Ram , Lamichhane Anita
Published: October 2019

The Study was conducted to evaluate the effectiveness of early tracheostomy and of late tracheostomy in neurosurgical critical patients. A retrospective chart review of Neurosurgical critical patients who underwent Tracheostomy from September 2017 to March 2019. Patients were divided into two groups: early tracheostomy occurring within 7 days and late tracheostomy after 7 days of mechanical ventilation. Two groups were compared in terms of days under ventilation, Complication and outcome. There were 30 patients over 18 month period. Age range from 18years to 86 years with means of 52.93±16.59 years. Male: Female ratio was 3:1. 12 (40%) had Early tracheostomy (ET) and 18 (60%) had Late tracheostomy (LT). Day on ventilation on ET group was 14.8±10.25 while on LT group was 20±8.4.Procedure related complication were more common in Late tracheostomy group with 11.11% and 16.66% tracheostomy site hematoma and pneumonia respectively, and subcutaneous emphysema were 8.33% of LT versus a 5.55% of ET, Stomal site infection were 11.11% in late tracheostomy versus 8.33% in ET. Early tracheostomy compare to late tracheostomy reduces the days on Mechanical ventilation, the ICU length of stay, hospital stay and procedural related complication, but it does not affect the mortality rate.
Epidural anesthesia masking pain from spinal epidural hematoma
Authors: Kokubo Rinko , Kim Kyongsong , Kim Chol , Matsuda Akihisa , Morita Akio
Published: October 2019

Spinal epidural hematoma (SEDH) without pain due to epidural anesthesia is a rare but serious complication. We report the successful treatment of a patient with progressive paraparesis after the development of SEDH during the administration of epidural anesthesia. An 84-year-old woman underwent laparoscopy with epidural anesthesia. To prevent deep vein thrombosis, the delivery of low molecular weight heparin was started 16.5 hours after laparoscopy. On the 1st postoperative day she reported painless leg paralysis and on the 2nd day she manifested severe paraplegia and urinary retention. Magnetic resonance imaging revealed an SEDH compressing the spinal cord at the Th12 - L1 and we performed emergent laminectomy. After the laminectomy her symptoms disappeared completely. SEDH is a rare but serious complication related to epidural anesthesia. As its excessive analgesic effect may elicit motor weakness and mask pain, SEDH must be ruled out in patients with paraparesis with continuous epidural anesthesia.
Pediatric intracerebral anaplastic ganglioglioma : A Case Report
Authors: Shrestha Dipendra Kumar , Rajbhandari Binod , Pradhanang Amit , Shilpakar Sushil Krishna
Published: October 2019

Anaplastic ganglioglioma (AGG) is an extremely rare aggressive, epileptogenic braintumor. It is considered to be WHO grade III variant of ganglioglioma. Due to non-specific clinical manifestations and radiographic features, preoperative diagnosis of AGG may be very difficult at times. Frequently, it may be confused with either low grade ganglioglioma, dysembryoplastic neuroepithelial tumor (DNET) or high grade primary glial tumors. Here, were port a young girl presenting with headache and seizures preliminarily diagnosed as DNET but histopathologically proven as an aplastic ganglioglioma, along with a brief literature review.
Copyright Literacy of Library and Information Science Students in the United States
Authors: Saunders Laura , Estell Allison N.
Published: October 2019

Copyright has an impact on nearly every aspect of the information professions, from developing collections to creating local policy and educating patrons. Given the apparent importance of copyright to information professionals, it is crucial that librarians and other information professionals be prepared for copyright-related responsibilities through their degree programs and that they be comfortable in their knowledge of copyright issues. However, there is limited research on the copyright literacy of librarians, relying mostly on their self-perceptions of their copyright literacy, and virtually no research on the copyright knowledge or training of LIS students. The current study expands upon previous research by surveying LIS students to determine how familiar they believe they are with certain copyright topics, and to explore their subjective sense of professional preparation with regard to copyright law and practice. The results of this study will be of interest to library managers interested in the copyright knowledge and preparation of emerging professionals and might also inform curricular decisions for LIS programs interested in ensuring adequate preparation for their students.
Sufficiency of Cataloging Education: School Librarians Respond
Authors: Engelson Leslie A.
Published: October 2019

No standardized learning outcomes exist for the cataloging education of school librarians in library and information science (LIS) programs. Additionally, LIS programs teach cataloging concepts in a variety of ways over various timeframes, raising the question of what it is that LIS programs should teach about cataloging and classification to prospective school librarians. The current literature offers limited guidance but does indicate that both theory and practice are important in the process of learning cataloging. A survey of school librarians was conducted to determine which cataloging and classification tools they use and which skills related to cataloging and classification are most important. Results indicate that few school librarians use descriptive cataloging tools such as AACR2 or RDA. Additionally, school librarians do not rate or rank descriptive cataloging or controlled vocabulary as important skills. Since descriptive cataloging guidelines and controlled vocabulary provide support for FRBR user tasks and create a database that facilitates the many activities of school librarians, this article suggests that LIS programs adopt a curriculum that communicates the value of a standardized, quality catalog. Additionally, practicum opportunities with experienced catalogers are an important element of cataloging education and should be incorporated into the curriculum. Finally, LIS programs should be intentional about connecting students to resources such as discussion groups and professional development opportunities that will continue to support cataloging efforts after students graduate. Future research into simplifying descriptive cataloging guidelines and determining essential MARC coding will help guide curriculum development in LIS programs.
CUMHURİYET DÖNEMİ TÜTÜN VE SİGARA KAÇAKÇILIĞI BAĞLAMINDA SURİYE SINIR GÜVENLİĞİNE BAKIŞ (1923-1940)
Authors: BORLAT Barış
Published: October 2019

Tütünün Osmanlı Devletine girişi ve kârlı bir tarım ürünü

olarak görülmesi kaçakçılığı da beraberinde getirmiştir. Osmanlı Devleti tütün

tarımında, Avrupalı devletlerin denetimiyle birlikte kaçakçılığın çözümü için

silahlı önlemler başta olmak üzere değişik politikalar geliştirilmiştir. Ancak

sorunun çözümüne yüzeysel olarak bakıldığı için çözümden öte yeni sorunları da

ortaya çıkarmıştır.

Cumhuriyet döneminde tütün tarımının geliştirilmesi, milli

ekonomi politikaları içerisinde yer aldığı için kaçakçılık sorununun çözümü de

önemli konular arasında görülmüştür. Ancak devletin ekonomik gücüyle orantılı

olarak geliştirilebilen sınır güvenliği sorunu kısa vadede çözülememiştir. Bu

durum Türkiye’de sınır kaçakçılığını ve kârlı görülen bu uğraştan faydalanmak

isteyen grupları ortaya çıkarmıştır. Kaçakçılık yapan kişilerin bunun dışında

diğer yasa dışı oluşum ve eylemlerde de bulunması yaygın bir kullanıma sahip

olan tütün kaçakçılığını ön plana çıkarmıştır.

Kaçakçılar zamanla kendilerine has yöntemler geliştirmekle

birlikte, bu tecrübelerini etrafına, yoğun olarak da ailesine aktararak bu

olguyu gelenekselleştirmiştir. Sorunun en önemli boyutu ise kaçakçılık ve

eşkıyalık yaklaşımlarının paralel olarak ilerlemesidir.

Atatürk Dönemi Tütün ve Sigara Kaçakçılığı (1923-1938)

başlıklı tez çalışmamdan genişleterek hazırlamış olduğum makalemde kaçakçılık,

kaçakçılık güzergâhları, kaçakçıların profilleri, eşkıyalığın kaçakçılığa

etkileri ve sorunun çözüm arayışları incelenmeye çalışılmıştır.
Türk Sigortacılık Sektörünün 2007-2018 Yıllarına Ait Performansının Oran Analizi Yöntemi ile Ölçülmesi ve Sektörün Ekonomik Büyüme Üzerindeki Etkisi
Authors: HAYIRSEVER BAŞTÜRK Feride
Published: October 2019

Araştırmada, finansal aracılık görevini gören sigorta sektörünün

performansının ölçülmesi ve ekonomik büyüme üzerindeki etkisinin incelenmesi

amaçlanmıştır. İlk olarak Türk Sigortacılık Sektörünün 2007-2018 yılları

arasındaki performansı oran analizi yöntemi ile değerlendirilmiş, ikinci olarak

Türkiye’de üretilen toplam primler ile GSYH arasındaki ilişki incelenmiştir.

Sigorta şirketlerinde finansal analizin amacı, şirketlerin finansal yapısının

dayanıklılığının saptanmasıdır. Sigorta şirketlerinin aktif kaliteleri ödeme

gücünün yeterliliği açısından oldukça önemlidir. Sigorta şirketlerinin

aktifleri bir yandan getiri sağlarken bir yandan da nakit ihtiyacını

karşılayabilecek likidite yapısında olmalıdır. Hayat dışı branşlarda aktif

kalitesi ve likidite oranları olması gereken seviyenin altında iken, hayat

branşında ise yeterli düzeydedir. Hayat dışı branşta Muallak Hasar Karşılıkları

hasar prim oranının artmasına sebep olmuştur. Bileşik oran, hayat dışı branşta

hayat branşından daha yüksek olarak görülmektedir. Teknik karşılık oranlarında sektör

genelinde büyük bir sorun gözükmese de, hayat dışı branşta özellikle

özsermaye/teknik karşılık oranının hayat branşına göre daha yüksek seyrettiği

görülmektedir. Ayrıca toplam primler ile ekonomik

büyüme arasında pozitif yönlü bir ilişkinin söz konusu olduğu gözlemlenmiştir.
Événements indésirables au cours de transfert interhospitalier de patients présentant un syndrome coronaire aigu non ST+
Authors: Lenglet A. , Balen F. , Charpentier S. , Sourbes A. , Arcuset D. , Delonglée V. , Fort P.A. , Bounes V. , Dadone B. Charriton
Published: October 2019

Introduction : Cette étude a pour objectif de connaître l’incidence et la nature des événements indésirables (EI) se produisant lors des transports interhospitaliers (TIH) des patients souffrant d’un syndrome coronarien aigu sans sus-décalage du segment ST (SCA non ST+). L’objectif secondaire est d’étudier les performances pronostiques des différentes évaluations de risque existantes de ces malades (score de GRACE, score de TIMI, grille de Fiancette et niveau de risque de la Société européenne de cardiologie [ESC]) dans la prédiction de ces EI.

Méthode : Il s’agit d’une étude de cohorte multicentrique rétrospective. Du 1er novembre 2016 au 31 octobre 2017, les patients SCA non ST+ et bénéficiant d’un transport secondaire ont été inclus à partir des fiches de régulation de trois Samu du sud-ouest de la France. Les types d’EI ont été recueillis. Les différents scores ont été calculés pour chaque patient ainsi que leur performance pronostique (sensibilité, spécificité, valeurs prédictives positives [VPP] et négatives [VPN]).

Résultats : Sur un an, 315 patients ont été inclus, et neuf patients (3 % ; IC 95 % : 1,3–5,3) ont présenté un EI. Soixante-dix-huit pour cent des événements recueillis n’ont pas engagé le pronostic vital des patients, et 40 % n’ont pas nécessité d’intervention thérapeutique nécessitant la présence physique d’un médecin. Aucun score n’est retrouvé statistiquement significatif dans la prédiction des EI. Toutefois, la stratification du risque de la ESC semble être la plus simple d’utilisation tout en assurant une valeur prédictive négative de 98 % (IC 95 % : 94–99).

Conclusion : Il y a peu d’EI lors du transport des SCA non ST+. L’utilisation en régulation de l’évaluation du risque ischémique de la ESC pourrait réduire la surmédicalisation de ces malades au bénéfice des TIH.
RANCANG BANGUN SISTEM MONITORING DETAK JANTUNG MENGGUNAKAN ELEKTROKARDIOGRAF BERBASIS BLUETOOTH DAN LABVIEW
Authors: Alam Syah , Hartanto Sri , Pratama Ikbal
Published: October 2019

Elektrokardiograf  (EKG) adalah alat yang digunakan untuk mendeteksi detak jantung pada manusia yang biasa digunakan di rumah sakit khususnya pada ruang ICU. Pada umumnya alat EKG dikendalikan secara manual menggunakan medium kabel sehingga memiliki keterbatasan jarak dan akses untuk melakukan monitoring. Penelitian ini mengusulkan rancang bangun prototype alat monitoring detak jantung pada manusia dengan berbasis arduino dan labview yang dikomunikasikan menggunakan Bluetooth agar dapat diakases secara efektif menggunakan wireless. Perancangan dilakukan menggunakan sensor elektroda yang dihubungkan dengan penguat awal, band pass filter, penguat akhir, rangkaian clamper dan arduino uno yang dihubungkan dengan modul bluetooth serial HC-05 dan dapat dimonitor menggunakan labview menggunakan Personal Computer (PC). Dari hasil pengujian dan pengukuran,  diperoleh jarak maksimal monitoring adalah 5 meter dengan tanpa halangan serta tingkat keakuratan detak jantung  96.1 % jika dibandingkan dengan detak jantung yang di deteksi dari nadi manusia. Hasil ini menunjukkan bahwa prototype yang diusulkan dapat bekerja dengan baik dan memenuhi syarat untuk dapat diaplikasikan pada sistem pendeketsi detak jantung manusia menggunakan elektrokardiograf.
Preliminary Capillary Flow Experiments with Amyloid-β, Possible Needle and Capillary Aβ Adsorption, and a Proposal for Drug Evaluation Under Shear Conditions
Authors: Trumbore Conrad N. , Paik Jennie , Fay David , Vachet Richard W.
Published: October 2019

Amyloid-β (Aβ) solution injections into an aqueous mobile phase moving through narrow bore stainless-steel capillary tubing results in adsorption of at least 99% Aβ within the tubing or injection valve. However, if flow is stopped for a period of 5–10 minutes, then started, wall desorption yields Aβ-containing molecules in the new effluent. The amount of desorbed Aβ-containing effluent depends on flow rate, period of flow cessation, and number of successive Aβ injections into the same tube without cleaning between injections. Unexpected multiple chromatographic peaks in these experiments seem to imply “separation” of released, previously adsorbed Aβ-containing products in the empty capillary tubing. These preliminary experiments raise questions about possible errors in Alzheimer’s disease (AD) spinal tap analyses, which use stainless-steel needles of approximately the same inner diameter and encounter similar flow rates as those in our capillary experiments. Microliter syringes and HPLC connectors also contain stainless-steel tubing that have similar inner diameter dimensions and similar flow rates. The capillary system involved in these experiments has previously been proposed as a model system for studying the effects of shear on Aβ within the brain because it offers a research environment that provides highly restrictive flow through very small dimension channels. A suggestion is made for the use of this system in exploratory anti-amyloid drug studies in which both the drug and Aβ are injected in the same solution so that both drug and Aβ are subjected to the same shear environment. Reduction in adsorbed Aβ is suggested as an indicator of effective anti-Aβ drugs.
Midlife Psychological Well-Being and its Impact on Cognitive Functioning Later in Life: An Observational Study Using a Female British Birth Cohort
Authors: Nakanishi Miharu , Yamasaki Syudo , Nishida Atsushi , Richards Marcus
Published: October 2019

Background:

There is growing interest in public health strategies to modify dementia risk in midlife to reduce the burden of cognitive impairment in subsequent decades. Risk reduction messages should include key recommendations for women in response to the high prevalence of dementia observed in this population. Midlife is a critical period for dementia-related brain changes and psychosocial crises. Psychological well-being can improve resilience to crises, yet it is not well understood with respect to dementia risk reduction.

Objective:

This study aimed to examine the association between midlife psychological well-being and cognitive function in later life in women.

Methods:

The study included 703 women from the British 1946 birth cohort in the Medical Research Council’s National Survey of Health and Development. Psychological well-being at 52 years was assessed using the Ryff Scales of Psychological Well-being over six dimensions: autonomy, environmental mastery, personal growth, positive relations with others, purpose in life, and self-acceptance. Cognitive function at 69 years was measured using the Addenbrooke’s Cognitive Examination, Third Edition.

Results:

After controlling for cognitive ability at eight years, educational attainment by 26 years, occupational attainment and marital status by 53 years, depression, smoking, and physical exercise at 60–64 years, there was a significant association between greater personal growth and lower self-acceptance at 52 years, and better cognition at 69 years. However, there was no association between cognition and the other four Ryff scales.

Conclusion:

Most aspects of midlife psychological well-being, except for personal growth and self-acceptance, were not prospectively associated with cognition.
Genome-Wide Methylation of Mild Cognitive Impairment in Mexican Americans Highlights Genes Involved in Synaptic Transport, Alzheimer’s Disease-Precursor Phenotypes, and Metabolic Morbidities
Authors: Pathak Gita A. , Silzer Talisa K. , Sun Jie , Zhou Zhengyang , Daniel Ann A. , Johnson Leigh , O’Bryant Sid , Phillips Nicole R. , Barber Robert C.
Published: October 2019

The Mexican American population is among the fastest growing aging population and has a younger onset of cognitive decline. This group is also heavily burdened with metabolic conditions such as hypertension, diabetes, and obesity. Unfortunately, limited research has been conducted in this group. Understanding methylation alterations, which are influenced by both genetic and lifestyle factors, is key to identifying and addressing the root cause for mild cognitive impairment, a clinical precursor for dementia. We conducted an epigenome-wide association study on a community-based Mexican American population using the Illumina EPIC array. Following rigorous quality control measures, we identified 10 CpG sites to be differentially methylated between normal controls and individuals with mild cognitive impairment annotated to PKIB, KLHL29, SEPT9, OR2C3, CPLX3, BCL2L2-PABPN1, and CCNY. We found four regions to be differentially methylated in TMEM232, SLC17A8, ALOX12, and SEPT8. Functional gene-set analysis identified four gene-sets, RIN3, SPEG, CTSG, and UBE2L3, as significant. The gene ontology and pathway analyses point to neuronal cell death, metabolic dysfunction, and inflammatory processes. We found 1,450 processes to be enriched using empirical Bayes gene-set enrichment. In conclusion, the functional overlap of differentially methylated genes associated with cognitive impairment in Mexican Americans implies cross-talk between metabolically-instigated systemic inflammation and disruption of synaptic vesicular transport.
Low Amyloid-PET Uptake in Iowa-Type Cerebral Amyloid Angiopathy with Cerebral Venous Thrombosis
Authors: Bermejo-Guerrero Laura , Sánchez-Tejerina Daniel , Sánchez-Tornero Mario , Sánchez-Sánchez María del Carmen , Gómez-Grande Adolfo , Villarejo-Galende Alberto , Herrero-San Martín Alejandro Octavio , González-Sánchez Marta
Published: October 2019

Hereditary cerebral amyloid angiopathies (CAA) are rare disorders of early onset and severe course. We describe a 47-year-old patient with Iowa-type amyloid precursor protein ( APP) mutation-related hereditary CAA that manifested with concomitant lobar hemorrhage and venous sinus thrombosis. To analyze the cerebral amyloid-β burden, an amyloid-PET was performed, demonstrating low cortical retention except for the calcarine cortex. High amyloid retention was also found in the thalamus and pallidum. The co-occurrence of CAA and venous thrombosis has not been previously reported in Iowa CAA and its mechanism is yet to be elucidated. Low cortical florbetapir-PET uptake does not rule out CAA in young patients, who may benefit from genetic testing to reach diagnosis when suspicion is strong.
Plasma Neurofilament Light Chain in Primary Progressive Aphasia and Related Disorders: Clinical Significance and Metabolic Correlates
Authors: Matías-Guiu Jordi A. , Gómez-Pinedo Ulises , Forero Lucía , Pytel Vanesa , Cano Fátima , Moreno-Ramos Teresa , Cabrera-Martín María Nieves , Matías-Guiu Jorge , González-Rosa Javier J.
Published: October 2019

Background:

Primary progressive aphasia (PPA) is a heterogeneous syndrome that is difficult to diagnose at early stages. Plasma neurofilament light chain (NFL) has been proposed as a potential biomarker for PPA.

Objective:

To examine the diagnostic properties of plasma NFL in PPA and to evaluate its association with clinical stages of the disease and brain metabolism.

Methods:

Our study included 80 participants (13 with non-fluent, 12 with semantic, and 16 with logopenic variant PPA; 13 with amnestic Alzheimer’s disease [AD]; 13 with behavioral variant frontotemporal dementia; and 13 healthy controls). Plasma NFL concentration was measured using a high-sensitivity enzyme-linked immunosorbent assay (ELISA) kit. PET imaging was performed in a subgroup of patients.

Results:

NFL discriminated patients from controls with an area under the curve of 0.914 (95% CI, 0.843–0.984; p < 0.001) (cut-off: 76.46 pg/mL; 94% sensitivity, 76.9% specificity). There were no significant differences between clinical syndromes (PPA subtypes), the main clinical forms of dementia (frontotemporal dementia and AD), or the expected pathological groups (frontotemporal lobar degeneration-tau [FTLD-tau], FTLD-TDP43, and AD). NFL levels showed weak to moderate correlations with age and functional scale score. We found no significant correlation with the extent of hypometabolism observed on FDG-PET images.

Conclusion:

Plasma NFL is a non-specific marker of neurodegeneration, and may be helpful in the diagnosis of PPA. However, NFL does not permit differential diagnosis between PPA subtypes and is not correlated with the extent of neurodegeneration.
Radiomics study for differentiating gastric cancer from gastric stromal tumor based on contrast-enhanced CT images
Authors: Sun Zong-Qiong , Hu Shu-Dong , Li Jie , Wang Teng , Duan Shao-Feng , Wang Jun
Published: October 2019

PURPOSE:

To test the feasibility of differentiate gastric cancer from gastric stromal tumor using a radiomics study based on contrast-enhanced CT images.

MATERIALS AND METHODS:

The contrast-enhanced CT image data of 60 patients with gastric cancer and 40 patients with gastric stromal tumor confirmed by postoperative pathology were retrospectively analyzed. First, CT images were read by two senior radiologists to acquire subjective CT signs model, including perigastric fatty infiltration, perigastric enlarged lymph nodes, the enhancement and growth modes of gastric tumors. Second, the manual segmentation of gastric tumors from the CT images was performed by the two radiologists to extract radiomics features via ITK-SNAP software, and to construct radiomics signature model. Finally, a diagnostic model integrated with subjective CT signs and radiomics signatures was constructed. The diagnostic efficacy of three models in differentiating gastric cancer from gastric stromal tumor was compared by using receiver operating characteristic curves (ROC).

RESULTS:

There are statistically significant differences between the gastric cancer and gastric stromal tumor in the perigastric enlarged lymph nodes, growth mode and radiomics signature ( p < 0.05). The area under ROC curve (AUC), sensitivity and accuracy of subjective CT signs model were the lowest among the three models. While the combined model yields the highest AUC value (0.903), specificity (93.33%) and accuracy (86.00%) among the three models ( p = 0.03).

CONCLUSION:

The diagnostic model integrating subjective CT signs and radiomics signature can improve the diagnostic accuracy of gastric tumors.
Introductory words by the editor-in-chief
Authors: Fylypovych Liudmyla O.
Published: October 2019

The thematic focus of this issue of the journal "Religious Freedom" was determined by the International Scientific and Practical Conference "Religious Freedom: Updating of Family Values", held on September 24-25, 2018 in Kyiv, Ukraine. Since 1994, conferences, which discussed various aspects of the existence of religious freedom, have become traditional. They necessarily ended with publication of materials of public discussion. This year the conference was devoted to the XXV-year anniversary of the Ukrainian Association of Religious Studies (URA), authoritative in Ukraine and far beyond its borders. The conference was organized by the Institute of Philosophy named after G.S. Skovoroda of the National Academy of Sciences of Ukraine, the Ministry of Culture of Ukraine, the Ukrainian Association of Religious Studies, the Institute of Religious Freedom. People's deputies of the Verkhovna Rada of Ukraine, members of the government, representatives of the councils of churches and religious organizations were invited to the speeches and reports in the Grand Conference Hall of the National Academy of Sciences of Ukraine. Academician-secretary of the Department of History, Philosophy and Law of the National Academy of Sciences of Ukraine Valery Smoliy, Corresponding Member of the National Academy of Sciences of Ukraine, Director of the Institute of Philosophy named after G.S. Skovoroda Anatoly Yermolenko, Deputy Director, Head of the Department of Religious Studies of the Institute of Philosophy named after GS Skovoroda is Doctor of Philosophy, Professor Anatoly Kolodny.
Design and Performance Test of Rubber Grinding Machine
Authors: Novita Sri Aulia , Hendra Hendra , Jamaluddin Jamaluddin , Makky Muhammad , Fahmi Khandra
Published: October 2019

The quality of rubber processed materials, that is produced by the farmer is generally low and can be seen from their colour,  pollutants levels, foul odour and the very cheap price. To improve the quality of the rubber should be done both in terms of its treatment and processing equipment. The main objective of this research is to enhance and improve the quality of farmer's rubber processed materials by using natural coagulant which liquid smoke to agglomerate the rubber, and designing of rubber grinding machine. The component of rubber grinding machine including hopper, regulating entry materials, three rollers, pulleys and belt, outlet, gears, engine, regulating the thickness and chassis. In this research, the thickness rubber after grinding is 3-5 mm accordance with Indonesian National Standard rubber. Processed material rubber produced is white and no pollutants. The coagulant used was liquid smoke with a concentration of 10 -20%, where this addition affects the agglomeration speed of rubber and smelled slightly of smoke. The average rate of Feed is 48.58 kg / h, a capacity of the machine is 37.40 kg/hr and cost of operation is Rp. 650 / kg.
The Analysis on The Formulation of Integrated Pest Management Policy Strategy by Using Swot-AHP Method (A Case Study on Vegetable Plant Cultivation in Lampung Province)
Authors: Sudiono Sudiono , Sutjahyo Soerjono Hadi , Wijayanto Nurheni , Hidayat Purnama , Kurniawan Rachman
Published: October 2019

The objective of this research was to formulate a policy strategy for integrated pest management by using SWOT AHP methods (case study on vegetable cultivation in Lampung Province). This method used A’WOT; the combination of AHP (Analytical Hierarchy Process) analysis and SWOT (Strength-Weakness-Opportunity-Threat) analysis. The analysis result showed the main strength factors becoming the base for sustainable agricultural business were the availability of good structures and infrastructures both in production and marketing, and the availability of sufficient production structure (seeds) with good quality and quantity. The weakness factors becoming concern were dominantly lack of institutional funding (capital) for vegetable business, many problems in the integrated pest management (IPM) technology implementation stage, many problems in good agriculture practices (GAP), and numbers of families making their life as farmers. The opportunity factors were the availability of IPM and GAP technologies, growing campaign for consuming domestic products reducing import, and high government commitment to improve vegetable farmers’ welfare. The threats to concern were no protection operational base and farmer’s empowerment, very few institutional funding (capital) for vegetable business, and many problems in the GAP and technology implementation. Six strategies becoming priority in order were drafting the regulation and standard of operation that regulate IPM and GAP implementations; strengthening farmer’ institution, capital and agricultural insurance; drafting legality of operational protection and farmer’s empowerment; agricultural intensification in order to improve quantity, quality, safety, and environmental insight for food security and independency; optimization of technology transfer by socialization or education of IPM and GAP for vegetable crops; and inexpensive IPM system based controlling technology development and effective and efficient of alternative production structures.
ION CHROMATOGRAPHY METHOD FOR DETERMINATION OF ISOPROPYLAMINE CONTENT IN METOPROLOL SUCCINATE
Authors: More Rohan , Gosar Dr. Amit , Shaikh Dr. Tabrez , Joglekar Amit
Published: October 2019

A simple, sensitive, specific, linear and effective Ion chromatography method has been developed and validated for the determination of Isopropylamine content in Metoprolol Succinate. Isopropylamine is possible impurity that may be present in Metoprolol succinate samples. The method was validated as per International Council for Harmonisation (ICH) guidelines, for which limit of detection and limit of quantitation obtained were 29 ppm and 87 ppm respectively. % RSD for System precision observed was 1.38. The regression coefficient found for the linearity study was 0.9997. The % recovery of the spiked Isopropylamine in drug substance obtained was in the range of 83.2 to 100.7 from 50 % to 150 % level ensured the accuracy of the method. The method can be adapted to determine Isopropylamine content in Metoprolol Succinate drug substance (API).

Keywords: Ion chromatography (IC), Metoprolol Succinate, Isopropylamine, development, validation.
ВПЛИВ ІНОЗЕМНОГО КАПІТАЛУ НА БАНКІВСЬКУ СИСТЕМУ УКРАЇНИ В УМОВАХ ГЛОБАЛІЗАЦІЇ
Authors: Татар М. С. , Нужнова Ю. А. , Рябус К. М.
Published: October 2019

Formulation of the problem. In the last five years the number of insolvent banking institutions was reduced, however, the percentage of banks with foreign capital in the total number of banks was increased, which may affect the banking system stability and require a research of the positive and negative effects of foreign banks on Ukraine banking system. The aim of the research is analizing trends of the foreign capital presence in Ukraine banking sector and determination its positive and negative impact on Ukraine banking system. The subject of the research is the activity of foreign banks in Ukraine. The methods of the research: logical and meaningful method, method of comparison, methods of induction and deduction, etc. The hypothesis of the research. Existence of significant influence of foreign capital on Ukraine banking system. The statement of basic materials. The main tendencies of development of Ukrainian banks and place in ratings of state-owned banks and banks of foreign banking groups are analyzed. It has been found that according to different ratings, banks of foreign banking groups occupy the first leading five positions in the rating, while banks with state-owned shares occupy mostly middle positions. The positive and negative influence of the presence of foreign banks in the territory of Ukraine on the banking system of Ukraine is analyzed. The originality and practical significance of the research is determination the positive and negative impact of foreign capital banks on Ukraine banking system. Conclusions and perspectives of further research. Positive and negative influence of presence of foreign capital banks on the Ukraine banking system is analyzed, which is the basis for further research, in which it is planned to quantify the power of influence of individual banks with foreign capital on Ukraine banking system development, to determine the effectiveness of attracting foreign banking capital in Ukraine, to form a mechanism for admission of banks with foreign capital to the domestic banking services market.
关于河道综合治理水利工程施工管理的质量控制与分析
Authors: 李 永光
Published: October 2019

水利工程是一个国家基础设施建设的组成部分。我国地域广阔、河流众多,加强河道综合治理会产生良好的生态效益,水利工程的建设会带来就业、拉动地方经济增长。水利工程具有项目难度大、资金投入大、回收周期长的特点,做好施工管理的质量控制和分析显得十分重要。本文分析了水利工程施工管理中普遍存在的质量问题,通过对实践经验的总结,提出了相应的质量控制措施,希望对相关从业者有所借鉴意义,促进我国水利工程领域的发展。
探究农村饮水安全工程建设与发展
Authors: 刘 平春
Published: October 2019

近年来,随着国家经济水平的不断发展,农村经济也在不断的发展,农民的经济水平也在不断的提升,对于农村自来水饮用安全工程的建设是很多村民一直非常渴望的,饮用水的安全工程建设对群众的生活水平和文明的发展都起到了一定的积极作用,本文主要是对农村自来水饮水安全工程建设与发展进行探究。
对水利工程水闸施工技术的探讨
Authors: 吴 晓发
Published: October 2019

随着社会经济的进步,水利工程水闸施工技术在各种新兴科技的带动下呈现出良好发展态势。其综合性及实用性有着显著提高,在防洪抗洪方面发挥了重要作用。水闸施工为水利工程建设的核心,做好水闸施工是水利工程建设的前提保证,水闸的质量直接决定着后期水利工程的施工水平。本文对水利工程水闸施工技术进行探讨,以期对水利工程工作做一参考。
小型水利工程质量监督管理工作管理中存在的问题及对策
Authors: 吴 瑞卿
Published: October 2019

现阶段,小型水利工程需要承担繁重的任务,小型民生水利的成本明显提高,监督管理工作中也存在着诸多的问题,故而为了保证小型水利工程顺利开展,就应采取有效的应对措施,充分发挥小型水利工程的作用。
论水土保持技术在小流域治理中的应用
Authors: 石 磊
Published: October 2019

随着经济的快速发展,社会环境问题也变得越发严重。目前,环境治理成为社会各界人士关注的重点问题。水土保持技术作为环境治理的关键举措,对于环境保护及社会健康发展有着重要意义。本文主要对水土保持技术在小流域治理中的应用进行分析阐述,以供参考。
论水利工程河道治理存在的问题及管理
Authors: 涂 远凯 , 孙 超 , 夏 平峰
Published: October 2019

水利工程河道整治施工的参与主体较多,会受到诸多因素的影响,故而在河道治理过程中会存在诸多问题。对此,应采取有效措施,保护河道内的景观,加强河道治理效果。本文主要分析了水利工程河道治理中存在的问题及管理措施,以供参考。
水土保持在生态环境建设中的作用
Authors: 高 华
Published: October 2019

新时期下,我国经济的发展速度越来越快,在一定程度上也加剧了我国的生态环境问题。水土流失是我国目前昀主要的自然灾害之一,对我国生态环境的破坏力巨大。基于此,下文就水土保持在生态环境建设中的作用、水土流失对生态环境的影响以及相关的水土保持措施做了简单分析,希望对我国的生态环境建设有所启示和帮助。
水库运行管理及调度的有效方法分析
Authors: 张 榆海
Published: October 2019

通过有效的水库运行管理及调度工作,能不断提升水库整体的防洪蓄洪能力,同时还能够延长水库的寿命,让水库始终处于安全的运行状态下。本文首先对水库运行管理及调度工作中存在问题,然后提出有效的提升对策,望采纳。
橡胶坝技术在水利工程上的应用研究
Authors: 张 勇
Published: October 2019

在现阶段的水利工程施工中,橡胶坝技术的应用较为广泛。为此,本文对橡胶坝技术进行了详细分析,希望对提高我国水利工程橡胶坝施工质量有所帮助。
分析基层农田水利灌溉管理存在的问题及对策
Authors: 康 晓虎
Published: October 2019

不断改进和完善农田水利灌溉技术,一方面实现了农民的增产增收,另一方面也推动了现代农业的建设和发展。基层农田水利灌溉管理工作虽然得到了明显发展,但是受多种因素的影响,在灌溉管理方面依然存在着明显的问题,故而为保证农业的健康前行,就应采取有效的处理策略。
关于水利工程泵站的管理和运行的思考
Authors: 罗 智敏
Published: October 2019

水利工程是利国利民的重要工程,在经济发展与民生保障环节发挥着不可替代的作用。水泵站作为水利工程的重要组成部分,应当引起各方的高度重视。现阶段,水利工程泵站设备、人员与管理等环节都存在不同程度的问题。对此,相关部门需构建完善的管理制度,优化管理模式,以促进水利工程泵站的良好运行。基于此,本文围绕水利泵站的管理与运行展开探究。
水利水电工程中水库加固施工管理探讨
Authors: 闫 新强
Published: October 2019

社会的快速发展昀大限度地带动了水利水电工程的全面发展,人们对于水利水电工程的各个方面要求不断提高。作水利水电工程施工过程中的重要组成部分之一就是水库加固施工。水库加固施工在水利水电工程中有着举足轻重的作用,不仅对水库施工的整体性有着明显的影响,还对水利水电工程的综合服务性能有着重要的影响。本文首先分析了在水利水电工程加固施工中常见的施工问题,并针对前期的施工准备和加强加固施工管理的措施进行了深入地探讨,望对业界人士提供良好的参考意见。
地铁项目水土保持监测初探
Authors: 许 晓伟 , 吴 王燕
Published: October 2019

近年来,随着城市轨道交通,尤其是地铁的快速发展,给市民的出行带来了极大的便利,对促进城市经济的发展也具有深远的影响。然而,大量快速的集中建设,也导致了一系列的生态环境与水土流失问题,给脆弱的城市生态环境中造成较大的负担,若不加以重视,可能导致更严重的后果。本文结合宁波地铁的建设,主要探讨地下车站及区间盾构施工引起的水土流失问题及水土保持监测重难点,并通过实际工作经验提出相应解决方案。
新疆额敏县水资源开发利用、优化配置分析及建议
Authors: 肖 群
Published: October 2019

新疆额敏县是农牧业大县,近些年来,随着农牧业的快速发展,城市工业的壮大、人口的增长、农业产业的调整,对水资源的需求日益增大。针对当前额敏县对水资源过度开采,更加剧了水资源缺乏的程度。因此,如何合理优化配置水资源,实现对水资源的科学利用,用科学先进的管理方法进行科学管理,已成为额敏县水资源优化配置管理必然趋势。
浅析工业给排水管道布置设计及施工技术
Authors: 刘 龙
Published: October 2019

工业给排水系统在整个工业发展中占据着重要的地位,作为一项关键又错综复杂的工序,其具体的管道布置设计是否合理以及施工技术是够专业,直接决定着后期工程的质量。由于给排水管的管道非常多,而且各个功能的给排水管道的材质可能会不同,这就使得给排水管的设计以及布置具有很大的复杂性。本文基于此,对工业给排水的管道系统布置与给排水设计进行了初步研究。
西克尔水库放水涵洞及溢洪道防渗处理措施的探讨
Authors: 帕尔哈提 吐尔地 •
Published: October 2019

西克尔水库位于新疆喀什噶尔流域克孜河下游,针对西克尔水库溢洪道、放水涵洞应急防渗处理均采用坝体上游护坡铺设土工膜防渗、砼板护坡与垂直混凝土防渗墙结合形成完整的防护体系。
关于水利工程管理的现代化与精细化建设的思考
Authors: 李 佳齐
Published: October 2019

目前,随着我国经济的快速发展,国家逐渐提高了针对水利工程建设和管理的重视,加快水利工程的现代化和精细化建设针对水利工程的发展与运作来说有着重要的推助作用,同时也是实现水利工程可持续性发展的重要措施。基于此,我国重点提高了水利工程方面的投资,并且运用先进的技术,不断改进管理制度、推进改革、严格落实管理、加强水利工程社会效益,以此来建立更加合理且完善的水利工程管理机制。本文主要针对水利工程管理现代化和精细化的概念,以及目标和思路进行分析,并提出了相关的建设策略。
Tip 2 Diyabetli Hastalarda Dapagliflozin Tedavisinin Trombosit Fonksiyonları ve İnflamasyon Üzerine Etkisi
Authors: EREN Mehmet Ali , CİNDOĞLU Çiğdem , DİKEÇ GÖKÇE Burcu , GÖKÇE Ali , SABUNCU Tevfik
Published: October 2019

Dapagliflozin kardiyovasküler hastalıklarda güvenli ve yararlı olduğu gösterilen bir oral anti-diyabetik (OAD) ilaçtır. Dapagliflozinin kardiyovasküler olumlu etkilerinin kesin mekanizması tam olarak bilinmemektedir. Bu çalışmada, dapagliflozin kullanan hastalarda tedavinin trombosit fonksiyonunu gösteren ortalama trombosit hacmi (OTH) ve yeni inflamatuar belirteçler olan nötrofil lenfosit oranı (NLO) ve trombosit lenfosit oranı (TLO) üzerine etkilerini araştırmayı amaçladık. Daha önce OAD veya OAD+insülin tedavisi almakta iken tedaviye dapagliflozin eklenen, 18 yaş üstü tip 2 diyabeti olan hastaların dosyaları incelenerek, dapagliflozin tedavisi başlamadan önce ve tedaviden sonra 3-6 ay içindeki laboratuar verileri kaydedildi. Dapagliflozin tedavisi ile birlikte glukoz ve A1c değerleri anlamlı olarak azalırken (her iki p<0.001), hemoglobin, hematokrit ve NLO değerleri anlamlı olarak arttı (sırasıyla p=0.005, p=0.001 ve p=0.032). Ayrıca nötrofil sayısı anlamlı olarak artarken, lenfosit sayısı anlamlı olarak azaldı (p=0.029 ve p=0.019). Dapagliflozin etkili bir OAD olup vücuttaki inflamasyon üzerine etkileri bulunmaktadır. Bu etkinin nasıl ve neden olduğunun anlaşılmasına ihtiyaç vardır.
PENENTUAN KONDISI KESEIMBANGAN UNIT LEACHING PADA PRODUKSI EUGENOL DARI DAUN CENGKEH
Authors: Tagora Bangkit P.S  , Rinaldry Sirait  , Iriany
Published: October 2019

Leafs of clove is an alternative source to obtain clove oil. Clove oil is classified into essential oil with eugenol as its main component. Clove oil is widely used in pharmaceutical, food and beverage industries. The objective of this research is to obtain clove oil by solid-liquid extraction (leaching). This research was expected to give data of solid-liquid equilibrium for designing solid liquid extractor. This research was carried out by leaching process with ethanol as its solvent. The extract was then purified by distillation to separate solvent from oil. The fixed variables which were used in this research were stirring rate of 460 rpm and 90 grams dry-based clove leaf. Extraction process was carried out by using solvent with temperature of 30oC and 50oC, extraction time of 1-3 hours with 0.5 hour increment and solvent volume of 500 ml and 600 ml. The results showed that the highest yield of clove oil extraction was obtained at temperature of 50oC and solvent volume of 600 ml. Equilibrium was reached after 2.5 hours and 79%  eugenol concentration in the solvent.
PENGARUH PENCUACAAN ALAMI TERHADAP PRODUK LATEKS KARET ALAM BERPENGISI TEPUNG KULIT PISANG YANG DIPUTIHKAN DENGAN HIDROGEN PEROKSIDA
Authors: Emelya Khoesoema  , Erick Kamil  , Hamidah Harahap
Published: October 2019

The effect of exposing bleached banana skin powder-filled natural rubber products to sun light and weather with variation of bleached banana skin powder filler loading. Banana skin powder was dried and bleached with hydrogen peroxide and made into disperse system. Natural rubber latex was compounded with bleached banana skin powder with filler loading of 0 to 20 phr (per hundred rubber). Natural rubber latex products, which were produced, were hung in air and exposed to sun light and weather. The degradation of bleached banana skin powder-filled natural rubber products were evaluated by calculating weight loss of samples and performing Fourier transform infrared spectroscopy (FTIR) test. Natural rubber latex lost weight after exposure to sun light and weather from 1 to 16 weeks due to photo-oxidation process.