bluuebunny/crossref_metadata_2025 huggingface dataset:
HMGA2 Variants in Silver-Russell Syndrome: Homozygous and Heterozygous Occurrence
Authors: Hübner Christian Thomas , Meyer Robert , Kenawy Asmaa , Ambrozaityte Laima , Matuleviciene Ausra , Kraft Florian , Begemann Matthias , Elbracht Miriam , Eggermann Thomas
Published: May 2020

Context

Silver-Russell syndrome (SRS) is a clinical and molecular heterogeneous disorder associated with short stature, typical facial gestalt, and body asymmetry. Though molecular causes of SRS can be identified in a significant number of patients, about one-half of patients currently remain without a molecular diagnosis. However, determination of the molecular cause is required for a targeted treatment and genetic counselling.

Objective

The aim of this study was to corroborate the role of HMGA2 as an SRS-causing gene and reevaluate its mode of inheritance.

Design, Setting, Patients

Patients were part of an ongoing study aiming on SRS-causing genes. They were classified according to the Netchine-Harbison clinical scoring system, and DNA samples were investigated by whole exome sequencing. Common molecular causes of SRS were excluded before.

Results

Three novel pathogenic HMGA2 variants were identified in 5 patients from 3 SRS families, and fulfilling diagnostic criteria of SRS. For the first time, homozygosity for a variant in HMGA2 could be identified in a severely affected sibpair, whereas parents carrying heterozygous variants had a mild phenotype. Treatment with recombinant growth hormone led to a catch-up growth in 1 patient, whereas all others did not receive growth hormone and stayed small. One patient developed type 2 diabetes at age 30 years.

Conclusions

Identification of novel pathogenic variants confirms HMGA2 as an SRS-causing gene; thus, HMGA2 testing should be implemented in molecular SRS diagnostic workup. Furthermore, inheritance of HMGA2 is variable depending on the severity of the variant and its consequence for protein function.
FSH Levels Are Related to E-cadherin Expression and Subcellular Location in Nonfunctioning Pituitary Tumors
Authors: Kolnes Anders J , Øystese Kristin A B , Olarescu Nicoleta C , Ringstad Geir , Berg-Johnsen Jon , Casar-Borota Olivera , Bollerslev Jens , Jørgensen Anders P
Published: May 2020

Context

Gonadotroph pituitary neuroendocrine tumors (PitNETs) can express follicle-stimulating hormone (FSH) and luteinizing hormone (LH) or be hormone negative, but they rarely secrete hormones. During tumor development, epithelial cells develop a mesenchymal phenotype. This process is characterized by decreased membranous E-cadherin and translocation of E-cadherin to the nucleus. Estrogen receptors (ERs) regulate both E-cadherin and FSH expression and secretion. Whether the hormone status of patients with gonadotroph PitNETs is regulated by epithelial-to-mesenchymal transition (EMT) and ERs is unknown.

Objectives

To study the effect of EMT on hormone expression in gonadotroph nonfunctioning (NF)-PitNETs.

Design

Molecular and clinical analyses of 105 gonadotroph PitNETs. Immunohistochemical studies and real-time quantitative polymerase chain reaction were performed for FSH, LH, E-cadherin, and ERα. Further analyses included blood samples, clinical data, and radiological images.

Setting

All patients were operated on in the same tertiary referral center.

Results

NF-PitNET with high FSH expression had decreased immunohistochemical staining for membranous E-cadherin (P < .0001) and increased staining for nuclear E-cadherin (P < .0001). Furthermore, high FSH expression was associated with increased ERα staining (P = .0002) and ERα mRNA (P = .0039). Circulating levels of plasma-FSH (P-FSH) correlated with FSH staining in gonadotroph NF-PitNET (P = .0025). Tumor size and invasiveness was not related to FSH staining, E-cadherin, or ERα. LH expression was not associated with E-cadherin or ERα.

Conclusion

In gonadotroph PitNETs, FSH staining is related to E-cadherin, ERα expression, and circulating levels of P-FSH. There was no association between FSH staining and invasiveness. The clinical significance of these findings will be investigated in ongoing prospective studies.
Building Intradisciplinarity in English Studies through Textual Hybridity and Performance
Authors: Sutherland Stephen
Published: May 2020

To build on the legacy of reader-response theory, English studies needs to destabilize the foundational binary separation of reading and writing by creating stronger intradisciplinary relations between composition and literary studies. English studies professors can do so by foregrounding the hybridity and performativity of the texts they teach and study.
Confronting the Real
Authors: Robillard Amy E.
Published: May 2020

This article considers the role of real-world writing pedagogy in the persistence of the real world/academy binary that fuels contemporary trigger warning debates, arguing instead for attention to the actual rhetorical constraints of the classrooms we all work in regularly.
“Give Books a Chance, Even the Really Weird and Bizarre Ones”
Authors: Lota Kenneth
Published: May 2020

This article uses a contemporary literature class titled Alternatives to Realism that the author taught at the University of North Carolina at Chapel Hill as the basis to argue for the special value of experimental, speculative, and otherwise antirealistic literature for introductory-level undergraduate literature pedagogy. The author argues that, rather than choosing realistic narratives that students are likely to understand and relate to on first pass, professors should deliberately seek out works students are likely to initially find confusing or strange and then endeavor to help them understand those texts. The article suggests that the difficulty associated with such texts, rather than intimidating students, actually invites them to engage with the reading process more actively and enthusiastically. The article discusses the premise and overall structure of the class and the rationale behind it; delves into specific examples of discussions and assignments based on such texts as Mark Z. Danielewski’s House of Leaves and Martin Amis’s Time’s Arrow; and examines students’ own ultimate responses to the class as presented in their final exam reflection essays. Ultimately, the author argues that teaching (seemingly) difficult, idiosyncratic literary works helps students appreciate the unique intellectual work of reading, strengthens their self-confidence, and leads them to a keener appreciation of the humanities more broadly.
Development of vascular regulation in the zebrafish embryo
Authors: Bahrami Nabila , Childs Sarah J.
Published: May 2020

The thin endothelial wall of a newly formed vessel is under enormous stress at the onset of blood flow, rapidly acquiring support from mural cells (pericytes and vascular smooth muscle cells; vSMCs) during development. Mural cells then develop vasoactivity (contraction and relaxation) but we have little information as to when this first develops or the extent to which pericytes and vSMCs contribute. For the first time, we determine the dynamic developmental acquisition of vasoactivity in vivo in the cerebral vasculature of zebrafish. We show that pericyte-covered vessels constrict in response to α1-adrenergic receptor agonists and dilate in response to nitric oxide donors at 4 days postfertilization (dpf) but have heterogeneous responses later, at 6 dpf. In contrast, vSMC-covered vessels constrict at 6 dpf, and dilate at both stages. Using genetic ablation, we demonstrate that vascular constriction and dilation is an active response. Our data suggest that both pericyte- and vSMC-covered vessels regulate their diameter in early development, and that their relative contributions change over developmental time.
Emerging views of genome organization in Archaea
Authors: Takemata Naomichi , Bell Stephen D.
Published: May 2020

Over the past decade, advances in methodologies for the determination of chromosome conformation have provided remarkable insight into the local and higher-order organization of bacterial and eukaryotic chromosomes. Locally folded domains are found in both bacterial and eukaryotic genomes, although they vary in size. Importantly, genomes of metazoans also possess higher-order organization into A- and B-type compartments, regions of transcriptionally active and inactive chromatin, respectively. Until recently, nothing was known about the organization of genomes of organisms in the third domain of life – the archaea. However, despite archaea possessing simple circular genomes that are morphologically reminiscent of those seen in many bacteria, a recent study of archaea of the genus Sulfolobus has revealed that it organizes its genome into large-scale domains. These domains further interact to form defined A- and B-type compartments. The interplay of transcription and localization of a novel structural maintenance of chromosomes (SMC) superfamily protein, termed coalescin, defines compartment identity. In this Review, we discuss the mechanistic and evolutionary implications of these findings.
A influência das ideologias partidárias nos gastos públicos em assistência social nas capitais brasileiras
Authors: Scheeffer Fernando , De Faveri Dinorá Baldo , Da Silva Junior Eliel Santos
Published: May 2020

É notório que os termos “esquerda” e “direita” continuam sendo utilizados, mesmo que às vezes sem o devido rigor. Levando isso em consideração vem se estudando o quanto a ideologia impacta no comportamento dos atores políticos. Diante desse cenário, o presente trabalho explora a acepção dos termos e busca verificar em que medida há relação entre ideologia e investimentos públicos, mais especificamente direcionados à assistência social nas capitais brasileiras entre 2013 e 2016. Os investimentos foram acessados no Sistema de Informações Contábeis e Fiscais do Setor Público Brasileiro (Siconfi) e foi levado em consideração tanto o partido do prefeito quanto do vice-prefeito para construir o que se chamou de enquadramento ideológico (esquerda-esquerda, esquerda-direita, direita-esquerda e direita-direita). Foi acessado também o IDHM dos municípios, últimos dados disponíveis. Para análise, a pesquisa utilizou estatística descritiva e multivariada, considerando os dados por meio de três técnicas: box-plot, correlação de Spearman e regressão linear múltipla. Os resultados encontrados possibilitaram verificar que o impacto da ideologia política nos gastos sociais, contrariando o que se esperaria teoricamente, é nulo. Por sua vez, encontrou-se uma relação significativa entre IDHM e investimentos em assistência social. A variação de 1 ponto percentual em IDHM provoca uma variação positiva de 0,032 pontos percentuais no investimento (arrecadação/despesa).
Remunicipalização e coprodução do bem público: perspectivas de gestão dos serviços de água e saneamento
Authors: Yamamoto Érica Aline Ferreira Silva , Pereira José Roberto , Alcântara Valderí De Castro
Published: May 2020

A população mundial ainda enfrenta grandes desafios para que os serviços de água e saneamento atendam a todos, principalmente nas áreas rurais. Frente a uma tendência mundial, esses serviços encontram-se em um marco histórico de remunicipalização. Nesse contexto, calha bem a discussão do tema sob a ótica da coprodução do bem público. O objetivo é analisar como o processo de remunicipalização de serviços de água e saneamento pode representar uma possibilidade para o desenvolvimento da coprodução do bem público. Para tanto, optou-se por uma investigação teórica a partir da literatura nacional e internacional sobre o tema. Ao final, apresentamos uma agenda de estudos e hipóteses de pesquisa para as relações entre os processos de remunicipalização dos serviços de água e saneamento e o desenvolvimento da coprodução do bem público.
A relação entre incidência política e mobilização de recursos na agroecologia
Authors: Ruas Rafael Beghini , Schommer Paula Chies
Published: May 2020

O trabalho apresenta uma análise sobre a relação entre incidência política e mobilização de recursos para a causa da agroecologia. O foco é a trajetória da organização não governamental Centro de Estudos e Promoção da Agricultura de Grupo (Cepagro), considerando em particular suas relações. São focalizados dois exemplos de sua atuação, articulada a organizações, movimentos e redes, nas temáticas de gestão de resíduos orgânicos e de diversificação em áreas cultivadas com tabaco, no período de 2006 a 2018. A pesquisa, de caráter descritivo-analítico, baseia-se em dados coletados por meio de entrevistas semiestruturadas, documentos e observação participante natural e não sistemática. A partir da Teoria do Processo Político, as categorias de análise mobilizadas foram oportunidades políticas, repertórios de ação e redes sociais, complementadas no decorrer da pesquisa. A mobilização de recursos foi abordada como processo de fortalecimento organizacional, fundamentado na construção de uma base social de apoio técnico, político e monetário. Concluiu-se que, na relação entre a organização e o Estado, predomina uma postura de colaboração em torno das temáticas tratadas e da causa defendida. As ações de incidência política são realizadas com grupos de base, outras organizações e sociedade civil em geral. Ainda que o Estado crie as oportunidades políticas, as ações de incidência política e mobilização social executadas pelo Cepagro as influenciam. O processo de mobilização de recursos, monetários e não monetários, vai além daquela para a própria organização. Com efeito, trata-se de uma mobilização para a causa defendida.
Governança ambiental no Brasil: acelerando em direção aos objetivos de desenvolvimento sustentável ou olhando pelo retrovisor?
Authors: Adams Cristina , Borges Zilma , Moretto Evandro Mateus , Futemma Celia
Published: May 2020

A governança ambiental diz respeito aos processos e às instituições por meio dos quais os atores sociais – estatais e não estatais – se organizam e tomam decisões a respeito das questões ambientais (Moura, 2016; World Resources Institute, 2003). A complexidade e o caráter multiescalar dos problemas socioambientais colocam desafios que demandam ações coordenadas entre o Estado e a sociedade, para que caminhemos em direção a um desenvolvimento sustentável e socialmente justo. A partir da Constituição Federal de 1988 e da Conferência da Rio-92 (Camargo, Capobianco & Puppim, 2004), o processo de criação de estruturas político-institucionais (Little, 2003) para viabilizar a implementação das políticas ambientais ganhou impulso no Brasil e, a despeito das lacunas e dificuldades (Moura 2016, World Resources Institute, 2003), apresentou avanços notáveis tanto no nível federal, quanto nos Estados. Além disso, novos arranjos de governança ambiental foram sendo experimentados e aperfeiçoados a partir do envolvimento de múltiplos atores sociais na criação de institucionalidades, para lidarem com as incertezas e complexidades das questões socioambientais (Castro & Futemma, 2015).
Governança ambiental no Brasil: rumo aos objetivos do desenvolvimento sustentável (ODS)?
Authors: Seixas Cristiana Simão , Prado Deborah Santos , Joly Carlos Alfredo , May Peter Herman , Neves Estela M. Souza Costa , Teixeira Leonardo Ribeiro
Published: May 2020

A governança ambiental é peça-chave para atingir a Agenda 2030 da Organização das Nações Unidas (ONU). Este artigo explora o potencial do Brasil de aproximar-se dos Objetivos do Desenvolvimento Sustentável (ODS) da Agenda 2030. Para tanto, apresenta seus avanços e retrocessos, em particular após a Constituição Federal de 1988 enfocando: licenciamento ambiental; vegetação nativa; recursos pesqueiros; recursos hídricos; unidades de conservação; e mudanças climáticas. Concluímos o artigo apontando que os retrocessos impostos ao sistema de governança ambiental na última década, e principalmente no último ano, indicam que o país caminha em direção oposta ao futuro almejado pela Agenda 2030.
Pragmatics of Pathos in Modern Russian Communicative Behavior
Authors: Karasik V. , Yan Czin
Published: May 2020

The paper deals with pathetic communication in modern Russia. This type of verbal interaction is understood as public influence on addressees with emphasized dramatic expression, high style words and phrases, syntactic repetitions and antitheses. Pathos is appropriate in extraordinary or ritual situations and is fixed in the genres of political and media discourse and in emblematic texts of anthems. Pathos is critically taken in ordinary habitual situations and is perceived as pretentious behavior of people who would like to lift themselves by lowering their communicative partners.
Guidelines for Developing Listening Skills of Chinese Students in Business Russian
Authors: Koneva Natalya , Zhigulskaia Daria
Published: May 2020

Currently the Russian language is becoming increasingly popular in China, that’s why there is an increase in demand for the Chinese, who speak Russian. This leads to higher demand for developing materials tailored to Chinese students, who study business Russian. This article addresses the importance of developing listening skills in “Business Russian”, provides methodological guidelines and suggests exercises for developing listening skills (level B1).
Language and Discourse: Teaching Methods for Modern Discourse
Authors: Ryabova Anna
Published: May 2020

Discourse is a phenomenon that reflects the unique features of the recipient’s cultural and geopolitical affiliation. The purpose of the study is to reveal and identify the linguistic representation of critical discourse. The language tools used as the evaluative category of journalistic discourse are examined and highlighted. The teaching methods chosen to view the tools targeted at influencing the recipient are described. The relevance of the study is connected with the importance to learn the requirements of the modern discourse construction and the growing interest in the language communication impact on the assessment of the world events. The diversity of political discourse expressions is analyzed. The elements of the discourse comparative study are included, which allows us to trace the principles of discourse design by representatives of different cultures. The methods of discourse teaching aimed at critical thinking development and the proper argumentation choice are emphasized and examined.
The Problem of Metadiscourse Reconstruction in English Fiction
Authors: Fedotova Oksana
Published: May 2020

The article presents the method of reconstruction of metadiscourse in English narrative, which includes several stages. On the first stage, we determine characteristics that point at the author’s dialogue with the reader. The second stage distinguishes the explicit and the implicit dialogue of the author with the reader. On the third stage, the common space and time for the reader and the writer are fixed. The fourth stage deals with the process of generalization in metadiscourse. The fifth stage studies the use of conceptual metaphors in metadiscourse. The sixth stage reconstructs the position of observer in metadiscourse.
Premorbid social relationships and the course of schizophrenia in a 20-year follow-up study
Authors: Cechnicki Andrzej , Bielańska Anna , Arciszewska-Leszczuk Aleksandra , Kalisz Aneta , Błądziński Piotr , Daren Artur , Mętel Dagmara , Kruk Dawid
Published: May 2020

Cel pracy

Istotnym obszarem wskazującym na narastające ryzyko wybuchu psychozy i jej późniejszego niekorzystnego przebiegu jest pogarszające się funkcjonowanie społeczne a szczególnie brak wystarczających relacji społecznych. Celem badania była ocena związku pomiędzy jakością kontaktów społecznych i zakresem systemu wsparcia przed wybuchem choroby a wynikami leczenia w obszarze klinicznym i społecznym w różnych czasokresach przebiegu choroby przez okres 20 lat.

Metoda

Użyto dwuczynnikowej analizy wariancji ANOVA z jednym czynnikiem grupującym (kontakty społeczne) i jednym czynnikiem powtarzanego pomiaru (czas badania) dla wyników GAF, BPRS, DSM III Oś V oraz szereg prostych regresji liniowych dla związków pomiędzy tymi wskaźnikami wyników a Skalą Podtrzymania Społecznego Surtees’a.
Badana grupa: W okresie pierwszej hospitalizacji wyłoniono 80 osobową grupę zamieszkującą na terenie Krakowa, chorującą na schizofrenię, diagnozowaną zgodnie z kryteriami DSM IV TR, zbadaną sześciokrotnie: przy wpisie i wypisie w czasie pierwszej hospitalizacji, po 3, po 7, po 12 i po 20 latach. Analizie poddano 55 osób (69% grupy włączonej do badania), które przez 20 lat wykonały wszystkie badania.

Wyniki

Satysfakcjonujące, pozytywne kontakty przed wybuchem choroby przekładały się, zwłaszcza po 20 latach, na lepsze ogólne oraz społeczne funkcjonowanie i mniejszą ilość objawów, w szczególności negatywnych. Szersze wsparcie społeczne przed wybuchem choroby powiązane było z lepszym funkcjonowaniem ogólnym i społecznym pacjentów oraz mniejszym nasileniem objawów ogólnych, pozytywnych oraz negatywnych, jednak w tym ostatnim przypadku efekt zanikał po 20 latach.

Wnioski

Jakość i zakres kontaktów społecznych przed wybuchem choroby, a szczególnie satysfakcjonujące relacje w środowisku pozarodzinnym są istotnym czynnikiem rokowniczym wieloletniego korzystnego klinicznego i społecznego przebiegu psychoz z grupy schizofrenii.
Precários nos querem, rebeldes nos terão! Tecnopolítica e indignación, de la Geração à Rasca a Que se lixe a Troika!
Authors: Sola Morales Salomé
Published: May 2020

El objetivo principal de este artículo es analizar las prácticas tecnopolíticas y las estrategias ciberactivistas surgidas en Portugal a raíz de la protesta Geração à rasca en 2011. En una primera etapa, se exploran las principales características de los movimientos antiprecariedad y, en segundo, se investiga el uso táctico de internet y las redes sociales (RR.SS.) por parte de los principales colectivos. La contribución a la literatura existente radica en el enfoque propuesto: un análisis multidimensional que sitúa la comunicación digital en el terreno de las mediaciones, relacionándola con la cultura, la política y la sociedad y evitando reduccionismos o determinismos tecnológicos. La principal conclusión es que, a pesar de que internet fue clave en el nacimiento de los movimientos antiprecariedad, una vez que la acción colectiva ocupó las calles, las rr.ss. pasaron a ser una herramienta secundaria y de apoyo a la actividad off-line. Las funciones mas destacadas de las rr.ss. fueron el apoyo en la convocatoria de eventos, la denuncia ante la ineficiencia de los gobernantes y la creación de una comunidad indignada.
State of the art urology 100 years ago
Authors: Ellis Harold
Published: May 2020

One hundred years ago, on 27 May 1920, the inaugural meeting of the Section of Urology was held at the Royal Society of Medicine in London. The lecture, by Sir Peter Freyer KCB, paints a vivid picture of the state of art of urological surgery a century ago.
The characteristics and impact of hard-to-heal wounds: results of a standardised survey
Authors: Milne Jeanette , Searle Richard , Styche Tim
Published: May 2020

The effective management of hard-to-heal wounds has increasingly important implications for those who provide wound care services within healthcare systems. The burden of wounds in the population continues to grow, as does the demand for wound care, against a backdrop of cost constraints and increasing expectations. The need to improve both outcomes and efficiency in wound care is therefore paramount and the time taken to heal wounds is an important factor in determining both. Survey methodology was used to collect data across 10 community wound care providers in the UK, Ireland, Finland, Norway and Denmark between February and August 2017. This allowed for analysis of wounds and their characteristics, dressing selection and nursing practice across a typical wound caseload. Data from 1057 wounds demonstrates that the characteristics and consequences of hard-to-heal wounds are different from improving wounds. However, wounds are, in general, treated in the same way, irrespective of whether they are hard-to-heal or improving, suggesting that the healing status of a wound is not a major factor in treatment selection. Early intervention to return hard-to-heal wounds to a healing trajectory may be a useful approach to improving efficiency in wound care.
High operating temperature pBn barrier mid-wavelength infrared photodetectors and focal plane array based on InAs/InAsSb strained layer superlattices
Authors: Deng Gongrong , Chen Dongqiong , Yang Shaopei , Yang Chaowei , Yuan Jun , Yang Wenyun , Zhang Yiyun
Published: May 2020

Improving the operation temperature of the focal plane array (FPA) imagers is critical in meeting the demands to reduce the size, weight, and power (SWaP) for mid-infrared detection systems. In this work, we report the demonstration of a 15 µm-pitch 640×512 middle-format pBn FPA device with a 50% cutoff wavelength of 4.8 µm based on short period of InAs/InAsSb-based “Ga-free” type-II strained-layer superlattices, which achieves a high operating temperature (HOT) reaching 185 K. The pBn FPA exhibits a mean noise equivalent differential temperature (NETD) of 39.5 mK and an operability of 99.6% by using f/2.0 optics for a 300 K background at 150 K. The mean quantum efficiency is 57.6% without antireflection coating and dark current density is 5.39×10−5 A/cm2 at an operation bias of −400 mV, by which the mean specific detectivity(D*) is calculated as high as 4.43×1011 cm.Hz½/W.
Tailored optical potentials for Cs atoms above waveguides with focusing dielectric nano-antenna
Authors: Ang Angeleene S. , Shalin Alexander S. , Karabchevsky Alina
Published: May 2020

Tuning the near field using all-dielectric nano-antennas offers a promising approach for trapping atoms, which could enable strong single-atom–photon coupling. Here we report the numerical study of an optical trapping of a single Cs atom above a waveguide with a silicon nano-antenna, which produces a trapping potential for atoms in a chip-scale configuration. Using counter-propagating incident fields, bichromatically detuned from the atomic cesium D-lines, we numerically investigate the dependence of the optical potential on the nano-antenna geometry. We tailor the near-field potential landscape by tuning the evanescent field of the waveguide using a toroidal nano-antenna, a configuration that enables trapping of ultracold Cs atoms. Our research opens up a plethora of trapping atoms applications in a chip-scale manner, from quantum computing to quantum sensing, among others.
Femtosecond timing synchronization at megahertz repetition rates for an x-ray free-electron laser
Authors: Sato Tokushi , Letrun Romain , Kirkwood Henry J. , Liu Jia , Vagovič Patrik , Mills Grant , Kim Yoonhee , Takem Cedric M. S. , Planas Marc , Emons Moritz , Jezynski Tomasz , Palmer Guido , Lederer Max , Schulz Sebastian , Mueller Jost , Schlarb Holger , Silenzi Alessandro , Giovanetti Gabriele , Parenti Andrea , Bergemann Martin , Michelat Thomas , Szuba Janusz , Grünert Jan , Chapman Henry N. , Mancuso Adrian P.
Published: May 2020

A critical challenge of pump-probe experiments with x-ray free-electron
lasers (XFELs) is accurate synchronization of x-ray and optical
pulses. At the European XFEL we observed megahertz rate timing jitter
of

24.0

±

12.4

f
s

.
Lefelé az alagsorba
Authors: Polónyi István
Published: May 2020

Lefelé az alagsorba A tanulmány a hazai humánerőforrás helyzet alakulását igyekszik elemezni, nem függetlenül a kormányzati szakpolitikákban tíz éve bekövetkezett változásoktól. Megvizsgálja a belépési ráták alakulását a közép- és felsőoktatásban, a felsőoktatás részvételi rátáját, a felsőoktatási képzési szerkezetét, a korai iskolaelhagyók arányának és számának alakulását. Ezt követően túllépve az oktatáson, néhány demográfiai kérdést vesz górcső alá. Elemzi a születéskor várható élettartam és az iskolázottság összefüggését, valamint a népesség számának alakulását, és befejezésül a human development index változását az elmúlt tíz évben. A bemutatott tendenciák, – amelyeket számos ábra és diagram szemléltet – nem kedvezőek. Egyértelműen látszik a hazai emberi erőforrások egyre jelentősebb lemaradása a fejlett világtól. A folyamatokat érintő kormányzati szakpolitikák részletes elemzése ugyan meghaladja az írás vállalását, annyit azonban a befejezés leszögez, hogy e kormányzati szakpolitikák, részint meghatározóan a rövid távú gazdasági érdekeknek lettek alárendelve, részint egy szűkebb társadalmi réteget – a felső középosztályt – szolgálják.
POST BEFORE EATING: Motif Generasi Milenial Ponorogo dalam Fenomena Kuliner Kekinian
Authors: Kurniawati Annisa Dwi
Published: May 2020

Contemporary cuisine still becomes a culinary destination that is loved by millennials. The generation which is connected with the use of social media often uploads every social activity, including culinary. Posting pictures before eating on social media becomes an activity that is usually done by millennials before enjoying culinary. This study aims to determine the motives of the Ponorogo millennial generation in the act of posting before eating when they enjoy a culinary dish. This type of research is descriptive qualitative research with a phenomenological approach. Interview, observation, and documentation triangulation techniques are used to collect data from 20 informants who actively use social media to post before eating. The results showed that the motives of the millennial generation to take pictures before eating are as a means to share fun or hobbies, share information about current culinary recommendations, and show self-existence.Kuliner kekinian masih menjadi tujuan kuliner yang digandrungi oleh generasi milenial. Generasi yang dalam kehidupannya erat dengan penggunaan media sosial ini sering kali mengunggah setiap aktivitas sosialnya termasuk dalam hal kuliner. Membagikan gambar yang hendak dimakan ke media sosial menjadi suatu aktivitas yang biasa dilakukan oleh generasi milenial sebelum menikmati sajian kuliner. Penelitian ini bertujuan untuk mengetahui motif generasi milenial Ponorogo dalam melakukan tindakan posting before eating ketika akanmenikmati sajian kuliner kekinian. Metode penelitian yang digunakan penelitian kualitatif deskriptif dengan pendekatan fenomenologi. Teknik triangulasi yaitu wawancara, observasi dan dokumentasi digunakan untuk mengumpulkan data dari 20 orang informan yang aktif menggunakan media sosial untuk melakukan tindakan posting before eating. Hasil penelitian menunjukkan bahwa motif generasi milenial melakukan tindakan posting before eating antara lain sebagai sarana untuk menyalurkan kesenangan atau hobi, membagikan informasi tentang rekomendasi tempat kuliner kekinian dan menunjukkan eksistensi diri.
DAMPAK SOSIAL PARIWISATA TERHADAP MASYARAKAT DESA EKOWISATA PAMPANG GUNUNG KIDUL MENUJU DESA EKOWISATA BERKELANJUTAN
Authors: Rohani Elisa Dwi , Purwoko Yitno
Published: May 2020

Changes in tourism that are currently developing from mass tourism to form a special interest tourism encourage one of the villages in Paliyan District, Pampang to become an Ecotourism village by carrying out the concepts of conservation and education. In this study will discuss how the response and community involvement in the development of the village of Papang to become an ecotourism village, as well as social impacts for the community that emerged after tourism activities developed in the village of Pampang Ecotourism, both positive and negative impacts. To be able to produce findings and an adequate description of the social impacts that occur in Pampang Ecotourism Village, this research uses a descriptive method with the aim of being able to provide a description of the phenomena of social change obtained through interviews with community leaders and village activists and observations. From this research, it can be seen that the development of tourism in Pampang has more positive impacts on the community compared to the negative impacts including the growing spirit of togetherness, strengthening community organizations, increasing public awareness of preserving and protecting the environment through tourism and Ecotourism villages to become pilot villages in environmental innovation and management.Perubahan pariwisata yang saat ini berkembang dari pariwisata massal ke bentuk pariwisata minat khusus, mendorong salah satu desa di Kecamatan Paliyan yaitu Pampang untuk menjadi desa Ekowisata dengan  mengusung konsep konservasi dan edukasi. Dalam penelitian ini membahas bagaimana respon dan keterlibatan masyarakat dalam pengembangan Desa Papang untuk menjadi desa ekowisata, serta dampak sosial bagi masyarakat yang muncul pasca aktivitas pariwiata berkembang di Desa Ekowisata Pampang. Penelitian ini mengunakan metode deskriptif dengan tujuan untuk dapat memberikan gambaran fenomena-fenomena perubahan sosial yang diperoleh melalui wawancara tokoh masyarakat dan penggerak desa Ekowisata maupun observasi. Hasil penelitian menunjukan bahwa perkembangan pariwisata di Pampang lebih banyak berdampak positif bagi masyarakat dibandingkan dampak negative, diantaraya tumbuhnya semangat kebersamaan, penguatan organisasi masyarakat, peningkatan wawasan masyarakat, kesadaran melestarikan dan menjaga lingkungan melalui pariwisata dan desa Ekowisata menjadi desa pecontohan dalam inovasi dan pengelolaan lingkungan.
Places of memory in ruins and death's patrimonialization in Santiago and Bogotá
Authors: Bustamante Javiera , Guglielmucci Ana , Márquez Francisca
Published: May 2020

The article analyses the ruinous destiny and patrimonial strategies of two places used in contexts of violence: Patio 29 of the General Cemetery of Santiago de Chile and the niches of the Columbarios of the Central Cemetery of Bogotá in Colombia. The premise underlying this article is that although heritage administrations are inspired by a positivist idea of memory, they have been ineffective in avoiding processes of ruinification of both places. This investigation shows that there are natural and social processes that contradict patrimonial principles, leading to ruin as an outcome. In the tension between patrimonial principles and social processes, the ruin, due to its controversial nature, historicizes the places and allows to update the narratives around the memory. The article concludes that ruins - as materiality, affect and narrative memory - are an expression of these contradictions within society.
Digital Printing in Contemporary Art. A review for conservation decision-making
Authors: Anthonisen-Añabeitia Iraia , Olabarria Itxaso Maguregui
Published: May 2020

Art uses the contemporary tools developed at the time, because of their material and conceptual possibilities. Comparing with other media, computers and output devices have transformed our society and culture in the last decades more than ever. These resources offered an interesting research path for artists, generating consideration and discussion concerning its use and conservation. On this regard this paper focuses on two main aspects: the materials employed to produce digital prints (technologies, inks, substrates, finishing and mounting) and conservation issues such as terminology concerns, documentation and recording, long-term stability, and reproduction matters. Clear standards are needed in order to guarantee the conservation of these artworks, representative of this century.
Interdisciplinary Management of Visceral Artery Aneurysms and Visceral Artery Pseudoaneurysms
Authors: Berek Peter , Kopolovets Ivan , Dzsinich Csaba , Bober Juraj , Štefanič Peter , Sihotský Vladimír
Published: May 2020

The paper presents the results of treating 14 patients, namely eight patients with visceral artery aneurysms and six patients with visceral artery pseudoaneurysms. In 64.3% of the patients, the initial diagnosis was made based on the ultrasound examination. All the patients (100%) underwent CT angiography, while angiography was performed in 71.4% of the cases. Five (35.7%) patients with visceral artery pseudoaneurysms were emergently hospitalized; among them, the signs of bleeding were observed in 2 patients. In 9 patients, pathology was detected during tests for other conditions. Five (35.7%) patients underwent endovascular treatment, while 9 (64.3%) patients received surgical treatment. Endovascular interventions and open surgery demonstrated a nil mortality rate. After endovascular treatment, stent thrombosis was found in 1 patient. In the case of surgical treatment, visceral artery aneurysm was observed in 1 patient who underwent the resection of superior mesenteric artery pseudoaneurysm. Conclusions. The choice of the method of treating visceral artery aneurysms and visceral artery pseudoaneurysms depends on the location, size, anatomic features of the visceral arteries and the clinical course of the disease. Both endovascular and surgical treatment demonstrate good postoperative outcomes. Visceral ischemia is one of the most serious complications in the postoperative period, which can complicate both the diagnosis and the choice of treatment tactics.
Wpływ konsumpcji na tworzenie Ja w społeczeństwie ponowoczesnym – perspektywa psychologiczna
Authors: Drążkowski Dariusz
Published: May 2020

In the psychological works describing the relationship between the individual’s self and consumption, there are many references to the achievements of postmodernists dealing with this issue. Meanwhile, postmodernism understands in a different way than psychologists the basic concepts and mechanisms that allow explaining the relationship between the self and consumption. The aim of this article is to relate the basic statements of postmodernists on the self-creating by consumption of individual living in a postmodern society to the achievements of psychology, and in particular to the psychological understanding of the notion of the self and to the psychological theories and results of research explaining the relationship between the self and consumption. The article describes the definition of identity and lifestyle among postmodernists and presents how, in their opinion, the consumption of goods in postmodern society influences the formation of (unstable) identity. It was then described how identity is defined in psychology in the context of related concepts. The following parts of the article describe selected theoretical models describing the mechanisms of creating the self with the use of consumption and present the results of research testing these models. At the end of the article, conclusions were drawn from the comparison ofthe approach to the relationship between the self and the consumption of postmodernists to the approach of psychologists.
Co to znaczy, że psychologia jest nauką społeczną? Próba odpowiedzi na pytanie poprzez psychologiczną analizę migracji arabskiej do Europy
Authors: Kowalik Stanisław
Published: May 2020

Psychological research rarely undertakes macrosocial issues. An analysis of the specificity of research conducted in the framework of social sciences revealed that incorporating psychology into them is not only possible but also desirable if, while studying these macrosocial phenomena and processes, scientists take into account biological and social factors as well. Basing on the conceptions of evolutionary psychology and the findings of research on the situation of migrants fromArab countries to Europe, it has been shown what value resorting to psychological knowledge in the search for the solution to migration problems may have.
Funkcjonowanie dzieci, młodzieży i dorosłych w rodzinach rozłącznych przestrzennie na skutek migracji ekonomicznych
Authors: Bakiera Lucyna , Doiczman-Łoboda Natasza
Published: May 2020

The main goal of the article is to take a theoretical reflection on a spatially separated family (also called temporary incomplete or transnational) as a result of labor migration. Global socio-cultural changes and the evolution of individual attitudes towards the life are changing contemporary families. Despite the transformation the family plays a key role in human development, and adults not only highly value family life and children, but perceive the child as a source of personal and family happiness. The article presents the scope of economic migration of Poles and their impact on family life. The main remarks refer to the psychological effects of separation for children, adolescents and spouses. Attention is drawn to the risk of loneliness, parentification and parental alienation. This paper presents also an attempt to classify spatially separated families as a result of economic migrations.
Współczesne tabu językowe, czyli o czym nie mówią Polacy
Authors: Rogodzińska Katarzyna , Obrębska Monika
Published: May 2020

The issue of contemporary linguistic taboo seems to be an important one due to the fact that we deal with its consequences in scientific, as well as social and educational, discourse. However, it has not been explored extensively enough. This thesis aims to investigate the differences in lexical processing of taboo and neutral words. The data was collected in a two-steps procedure. Firstly, a questionnaire was used to examine what topics are considered to be taboo in different age groups. Secondly, a psychological experiment was conducted with use of E-Prime programme in order to investigate the difference in taboo and neutral words reaction time. 58 people participated in the experiment, divided into two age groups. No statistically significant differences were observed between taboo and neutral words reaction time. However, it was proven that the taboo words reaction time is, in fact, statistically significantly longer for people in middle adulthood stage than for students. This study considers emotional valence as the only factor distinguishing taboo words from neutral words. In the future, to enable more precise words selection, the study should consider other lexical properties of the words as well.
Wstęp
Authors: Banach Wiesław , Michalski Michał A. , Sójka Jacek
Published: May 2020

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Niekontekstualne rozumienie kultury gospodarczej
Authors: Zboroń Halina
Published: May 2020

Halina Zboroń, Niekontekstualne rozumienie kultury gospodarczej [Non-contextual understanding an economic culture] edited by W. Banach, M.A. Michalski, J. Sójka, „Człowiek i Społeczeństwo” vol. XLVI: Między Chinami a Zachodem. Pytanie o źródła chińskiego sukcesu gospodarczego [Between China and the West. An inquiry into the sources of the Chinese economic miracle], Poznań 2018, pp. 187–201, Adam Mickiewicz University. Faculty of Social Sciences Press. ISSN 0239-3271.The article aims to critical analyze the way of understanding an economic culture, especially a contextual approach which characterizes economists’ beliefs concerning as well economy as individuals participating in a social practice of production, exchange and consumption of goods and services. Moreover the author aims to present an alternative, non-contextual approach of an economic culture considered as a direct regulation of economic activities.
Ekonomia i etyka. Inspiracje konfucjańskie
Authors: Sójka Jacek
Published: May 2020

Ekonomia i etyka. Inspiracje konfucjańskie [Economics and ethics. Confucian inspirations] edited by W. Banach, M.A. Michalski, J. Sójka, „Człowiek i Społeczeństwo” vol. XLVI: Między Chinami a Zachodem. Pytanie o źródła chińskiego sukcesu gospodarczego [Between China and the West. An inquiry into the sources of the Chinese economic miracle], Poznań 2018, pp. 43–66, Adam Mickiewicz University. Faculty of Social Sciences Press. ISSN 0239-3271.The aim of this article is to assess what kind of possible inspirations for economic thinking one can expect from Confucianism. A direct challenge was issued by the work of Kazimierz Poznański who claims that Confucianism is a source of a new paradigm for economics, the one based on ethics. So the question posed in this paper is, to what extent Confucian economics, as presented by Poznański, can become an alternative view counterposed to the western liberal economics, allegedly devoid of ethical contents. To answer that question one should first analyse the relation between economics and ethics within traditional, western, liberal approach. The author of this article posits that ethical component is present within this approach and, at the same time, Confucian values are not that different as far as the goals of economic life are concerned. What is more, one can find some conceptual affinities between Confucius and Adam Smith.
Domniemane i rzeczywiste przyczyny chińskiego cudu gospodarczego. Polemika z Kazimierzem Poznańskim
Authors: Rotengruber Przemysław
Published: May 2020

Domniemane i rzeczywiste przyczyny chińskiego cudu gospodarczego. Polemikaz Kazimierzem Poznańskim [Alleged and real reasons for the Chinese economy miracle. A polemicwith Kazimierz Poznański] edited by W. Banach, M.A. Michalski, J. Sójka, „Człowiek i Społeczeństwo”vol. XLVI: Między Chinami a Zachodem. Pytanie o źródła chińskiego sukcesu gospodarczego [BetweenChina and the West. An inquiry into the sources of the Chinese economic miracle], Poznań 2018,pp. 67–84, Adam Mickiewicz University. Faculty of Social Sciences Press. ISSN 0239-3271.

China has come a long way in the last hundred years. It is so long that it’s easy to forget about the problems that the Chinese had to face earlier. They struggled with patterns of long duration making it difficult for them to break out of the centuries-old stagnation. The Chinese were looking for new patterns of political culture. However, not only those patterns required a correction. If Fukuyama is right, the rules of caring for one’s family at the expense of social obligations have turned out to be no less troublesome. The Chinese way to prosperity led then not only through the public sphere, but also through the hearts and minds of the Chinese. They had to cut themselves off from the past. Meanwhile, in the time of economic prosperity, the longing for the past returns. The place of doctrines borrowed from the Western world replaces nostalgia. Deng Xiaoping’s political references to the teachings of Confucius are – in the blink of an eye – becoming the basic message. It is not surprising that the Chinese people want to forget about the embarrassing moments of their own history. These trends, however, should not affect external observers of economic life in China. One of such observers is Kazimierz Poznański. He believes that the cause of the Chinese economic miracle is the Confucian ethics (despite the historical changes shaping the Chinese mentality). The aim of the article is to verify this hypothesis.
Human Dental Pulp Stem Cells Exhibit Osteogenic Differentiation Potential
Authors: Awais Sadia , Balouch Samira Shabbir , Riaz Nabeela , Choudhery Mahmood S
Published: May 2020

Bone regeneration after trauma, pathologic and surgical procedures is considered a major medical challenge. Due to limitations in using conventional approaches, cell based regenerative strategies may provide an alternative option to address such issues. In the current study, we sought to determine the osteogenic potential of dental pulp stem cells (DPSCs) isolated from impacted 3rd molars. DPSCs were isolated from human dental pulp tissue (n=6) using explant culture. Growth characteristics of DPSCs were determined using plating efficiency, and the number and time of population doublings. After characterization, DPSCs were induced to differentiate into osteoblasts and were assessed using polymerase chain reactions (PCR) and histological analysis. Results indicated that DPSCs can be isolated from impacted human third molars, and that DPSCs exhibited typical fibroblastic morphology and excellent proliferative potential. In addition, morphological changes, histological analysis and expression of lineage specific genes confirmed osteogenic differentiation of DPSCs. In conclusion, DPSCs isolated from impacted 3rd molars have high proliferative potential and ability to differentiate into osteoblasts.