bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGARUH EKUITAS MEREK TERHADAP KEPUTUSAN PEMANFAATAN PELAYANAN RAWAT JALAN RUMAH SAKIT IBU DAN ANAK ANANDA TRIFA KOTA PAREPARE
Authors: Irma Asriani  , Usman  , Makhrajani Majid
Published: January 2020

Merek yang kuat akan menjadi daya tarik pelanggan, dengan merek yang kuat, tujuan mengembangkan dan merebut pasar akan lebih mudah tercapai. Dengan demikian Rumah Sakit saat ini harus secara berkelanjutan mengelola ekuitas merek (brand equity) sebagai salah satu intangible asset-nya. Brand equity yang kuat dapat terbentuk melalui kesadaran merek (brand awareness), persepsi kualitas (perceived quality), asosiasi merek (brand association), dan loyalitas merek (brand loyalty). Semakin kuat brand equity suatu produk, semakin kuat pula rasa percaya diri pelanggan dalam proses pengambilan keputusan pembelian, sehingga mengantar perusahaan untuk mendapatkan keuntungan dari waktu ke waktu. Penelitian ini bertujuan untuk mengetahui pengaruh ekuitas merek keputusan pemanfaatan pelayanan rawat jalan di Rumah Sakit Ibu dan Anak Ananda Trifa Kota Parepare. Metode penelitian ini merupakan penelitian kuantitatif. Data diperoleh dengan membagikan kuesioner kepada 45 pasien yang di jadikan sampel mulai bulan Juli sampai Agustus 2018. Analisis penelitian yang digunakan adalah uji chi-square.Hasil penelitian menunjukkan bahwa ada pengaruh yang signifikan antara elemen Brand Awareness, Perceived Qualitye, Brand Asosiasion, Brand Loyalty terhadap keputusan pemanfaatan pelayanan rawat jalan di Rumah Sakit Ibu dan Anak Ananda Trifa
HUBUNGAN ANTARA DUKUNGAN KELUARGA DENGAN TINGKAT KECEMASAN PASIEN PRE OPERASI DI RSUD ANDI MAKKASAU KOTA PAREPARE
Authors: Nofriani Mangera  , Haniarti  , Ayu Dwi Putri Rusman
Published: January 2020

Dukungan keluarga adalah sikap, tindakan dan penerimaan keluarga terhadap penderita yang sakit. Anggota keluarga memandang bahwa orang yang bersifat mendukung selalu siap memberikan pertolongan dan bantuan jika diperlukan. Kecemasan merupakan bagian dari kehidupan manusia yang ditandai dengan perasaan ketakutan atau kekhawatiran yang mendalam dan berkelanjutan. Berdasarkan data awal yang diperoleh dari Rumah Sakit Umum (RSUD) Andi Makkasau Kota Parepare pada tahun 2016 tercatat sekitar 1.254 pasien pre operasi dan pada bulan Mei 2017 tercatat sekitar 112 pasien pre operasi di Rumah Sakit Umum Andi Makkasau Kota Parepare. Penelitian ini bertujuan untuk mengetahui hubungan antara dukungan keluarga inti, dukungan keluarga di luar rumah, dan dukungan keluarga lain dengan tingkat kecemasan pasien pre operasi di Rumah Sakit Umum RSUD Andi Makkasau Kota Parepare. Jenis penelitian ini bersifat deskriptif dengan menggunakan pendekatan cross seetional yaitu pengumpulan data yang menggunakan kuesioner dengan jumlah sampel 112 responden. Teknik pengambilan sampel dalam penelitian ini menggunakan teknik accidental sampling. Sampel yang digunakan sebanyak 53 orang. Analisis data dengan menggunakan teknik Analisis Univarisat dan Analisis Bivariat. (uji statistik chi-square). Hasil penelitian, menunjukkan ada hubungan antara dukungan keluarga inti dengan tingkat kecemasan pasien pre operasi dengan nilai (ρ = 0,00) di Rumah Sakit Umum (RSUD) Andi Makkasau Kota Parepare. Disarankan kepada keluarga pasien untuk memberikan dukungan dan rasa nyaman kepada pasien sehingga pasien tidak cemas sebelum operasi, bagi tenaga kesehatan untuk lebih ditingkatkan dalam membantu keluarga pasien untuk menjalankan fungsinya dalam memberi dukungan agar tingkat kecemasan pasien pre operasi menjadi berkurang dan kepada keluarga pasien agar selalu mendampingi pasien dan memberikan motivasi yang baik sehingga pasien tidak cemas sebelum operasi
KAJIAN SISTEM PENCATATAN DAN PELAPORAN TERPADU PUSKESMAS (SP2TP) WILAYAH KERJA PUSKESMAS LAKESSI KOTA PAREPARE
Authors: Zulkifli  , Makhrajani Majid  , Darmawan Ukkas
Published: January 2020

Sistem Pencatatan dan Pelaporan Terpadu Puskesmas (SP2TP) merupakan salah satu faktor penentu keberhasilan manajemen kesehatan, dimanfaatkan untuk peningkatan upaya kesehatan di Puskesmas melalui perencanaan, penggerakan, pelaksanaan, pengawasan, pengendalian. Tujuan Penelitian adalah mengetahui tingkat pengetahuan, motivasi, koordinasi dan pengolahan data petugas pengelola Sistem Pencatatan dan Pelaporan Terpadu Puskesmas (SP2TP) Wilayah Kerja Puskesmas Lakessi Kota Parepare. Untuk memperoleh data dilakukan penelitian dengan metode deskriptif dengan pendekatan kualitatif yang dilakukan di Puskesmas Lakessi Kota Parepare pada bulan April sampai dengan September 2018. Sampel dalam penelitian ini adalah penanggung jawab program yang berada di Puskesmas Lakessi. Penentuan sampel dengan teknik total sampling dengan menggunakan kuisioner 47 responden dengan teknik wawancara mendalam. Hasilnya menunjukkan bahwa untuk meningkatkan pengetahuan perlu adanya suatu pelatihan yang diberikan kepada petugas, untuk meningkatkan koordinasi selalu diadakannya evaluasi terkait SP2TP. Sedangkan untuk pengolahan data perlu adanya feed back atau umpan balik dari Dinas kesehatan terkait laporan yang sudah dikirim oleh Pihak Puskesmas
HUBUNGAN FOOD CHOICE TERHADAP KESEHATAN MENTAL PADA REMAJA DI KOTA PAREPARE
Authors: Yayu Adenengsi  , Haniarti  , Ayu Dwi Putri Rusman
Published: January 2020

Kebiasaan mengkonsumsi makanan sehat telah berubah akibat perkembangan ekonomi yang begitu pesat. Hal ini ditandai dengan akses yang semakin mudah terhadap makanan yang tidak sehat dan juga harga yang lebih murah dibandingkan dengan makanan sehat. Tujuan untuk mengetahui hubungan food choice terhadap kesehatan menal pada remaja di Kota Parepare.Jenis penelitian yang digunakan adalah kuantitatif dengan pendekatan deskriptif. Desain yang digunakan adalah cross sectionalstudy. Populasi yaitu semua pengunjung remaja di lapangan Andi Makkasau Kota Parepare, pengambilan sampel dengan metode teknik non probability sampling sebanyak 99 orang diperoleh dengan menggunakan rumus Slovin. Analisis data dengan menggunakan chi square diterima jika nilai p < 0,05 dan  ditolak jika nilai p> 0,05.Hasil penelitian diperoleh tidak ada hubungan food choice terhadap kesehatan mental pada remaja dengan nilai (p = 0,676). Diharapkan kepada remaja untuk memperhatikan cara pemilihan makanan dan menjaga pola makan agar kesehatan remaja dapat terjaga khususnya pada kesehatan mental
FAKTOR RISIKO KEJADIAN PENYAKIT KULIT PADA NELAYA DI DESA TETEAJI KECAMATAN TELLU LIMPOE KABUPATEN SIDENRENG RAPPANG
Authors: Hajratul Aswad  , Muhammad Siri Dangnga  , Henni Kumaladewi Hengky
Published: January 2020

Penyakit kulit merupakan suatu penyakit yang masih menjadi masalah kesehatan masyarakat di Indonesia dan satu diantaranya yang terjadi pada nelayan dimana rentan untuk terkena penyakit kulit.Penelitian ini bertujuan untuk mengetahui faktor risiko lingkungan penyakitkulit yang terjadi pada nelayan di DesaTeteaji Kecamatan TelluLimpoe Kabupaten Sidenreng Rappang. Penelitian ini merupakan observasi  analitik dengan rancangan penelitian menggunakan desain cross sectional. Lokasi penelitian dilaksanakan di Desa Teteaji Kecamatan Tellu Limpoe Kabupaten Sidenreng Rappang.Sampel penelitian ini adalah Nelayan yang berumur 20-65 tahun dengan jumlah 51 orang. Data primer didapat dengan cara melakukan wawancara langsung mengenai gangguan penyakit kulit dan dengan melakukan observasi terhadap factor risiko lingkungan nelayan. Hasil analisis bivariat menunjukkan tempat pembuangan sampah bukan merupakan factor risiko kejadian penyakit kulit pada nelayan(p=0,507), kepadatan hunian merupakan factor risiko kejadian penyakit kulit (p= 0,048), tempat pembuangan kotoran merupakan factor risiko penyakit kulir pada nelayan (p=0,006), pH air bukan merupakan factor risiko lingkungan kejadian penyakit kulit pada nelayan (p=0,725). Disarankan kepada para nelayan agar lebih memperhatikan  keadaan  lingkungan khususnya sanitasi lingkungan agar terhindar dari penyakit menular terutama penyakitkulit. Kemudian  kepada tenaga kesehatan agar ikut terlibat dalam penyehatan lingkungan guna meningkatkan motivasi masyarakat untuk menjaga, meningkatkan dan memelihara kesehatan lingkungannya.
Investigating subclasses of abstract dialectical frameworks
Authors: Diller Martin , Keshavarzi Zafarghandi Atefeh , Linsbichler Thomas , Woltran Stefan
Published: January 2020

Abstract dialectical frameworks (ADFs) are generalizations of Dung argumentation frameworks where arbitrary relationships among arguments can be formalized. This additional expressibility comes with the price of higher computational complexity, thus an understanding of potentially easier subclasses is essential. Compared to Dung argumentation frameworks, where several subclasses such as acyclic and symmetric frameworks are well understood, there has been no in-depth analysis for ADFs in such direction yet (with the notable exception of bipolar ADFs). In this work, we introduce certain subclasses of ADFs and investigate their properties. In particular, we show that for acyclic ADFs, the different semantics coincide. On the other hand, we show that the concept of symmetry is less powerful for ADFs and further restrictions are required to achieve results that are similar to the known ones for Dung’s frameworks. A particular such subclass (support-free symmetric ADFs) turns out to be closely related to argumentation frameworks with collective attacks (SETAFs); we investigate this relation in detail and obtain as a by-product that even for SETAFs symmetry is less powerful than for AFs. We also discuss the role of odd-length cycles in the subclasses we have introduced. Finally, we analyse the expressiveness of the ADF subclasses we introduce in terms of signatures.
A Narrative Review of Handgrip Strength and Cognitive Functioning: Bringing a New Characteristic to Muscle Memory
Authors: Shaughnessy Keith A. , Hackney Kyle J. , Clark Brian C. , Kraemer William J. , Terbizan Donna J. , Bailey Ryan R. , McGrath Ryan
Published: January 2020

Background:

Measures of handgrip strength have not only emerged as a clinically viable screening tool for determining risk for morbidity, functional disability, and early mortality, but also for helping to identify cognitive deficits. However, the phenomena that links low handgrip strength with cognitive decline remains unclear. The role of the muscular and neural systems, and their adaptations to muscle strengthening activities over the life course, may provide important information for how age-related changes to muscle mass, strength, and neural capacity influence cognition. Moreover, disentangling how handgrip strength and cognitive function are associated may help to inform healthcare providers working with aging adults and guide targeted interventions aiming to preserve muscle and cognitive functioning.

Objective:

To 1) highlight and summarize evidence examining the associations of handgrip strength and cognitive functioning, and 2) provide directions for future research in this area.

Methods:

Articles from the PubMed database were searched from November 2018-May 2019. The search term algorithm, inclusion and exclusion criteria were pre-specified by investigators.

Results:

Several cross-sectional and longitudinal studies have revealed that measures of handgrip strength were associated with cognitive declines regardless of age demographics and the presence of comorbidities.

Conclusion:

Handgrip strength can be used in clinical and epidemiological settings for helping to determine the onset and progression of cognitive impairment. Future research should continue to examine how handgrip strength and cognitive function are linked.
Loss of Functional Dentition is Associated with Cognitive Impairment
Authors: Han Ji Hyun , Lee Hyo-Jung , Han Ji Won , Suh Seung Wan , Lee Ju Ri , Byun Seonjeong , Kim Keun Suh , Kim Sung Yeol , Lee Jung-Tae , Yoo Eunha , Chang Na-Hee , Kim Tae Hui , Kim Ki Woong
Published: January 2020

Background:

Although tooth loss is known to increase the risk of cognitive impairment and dementia, few studies have investigated the association between functional teeth including rehabilitated lost teeth and cognitive function

Objective:

We investigated the associations of the numbers of functional teeth and functional occlusal units with cognitive impairment and cognitive function in late life.

Methods:

The current study was conducted as a part of the Korean Longitudinal Study on Cognitive Aging and Dementia (KLOSCAD), a community-based elderly cohort study. We analyzed 411 participants who have agreed with the additional dental exam. Geriatric psychiatrists and neuropsychologists administered the Consortium to Establish a Registry for Alzheimer’s disease Assessment Packet Clinical and Neuropsychological Assessment Battery to all participants, and dentists examined their dental status.

Results:

Higher number of functional teeth (OR = 0.955, 95% CI = 0.914–0.997, p = 0.037) and higher number of functional occlusal units (OR = 0.900, 95% CI = 0.813–0.996, p = 0.042) were associated with lower odds of cognitive impairment. When we analyzed these relationships separated by the location of teeth, only the numbers of functional teeth (OR = 0.566, 95% CI = 0.373–0.857, p = 0.007) and functional occlusal units (OR = 0.399, 95% CI = 0.213–0.748, p = 0.004) in the premolar area were associated with lower odds of cognitive impairment.

Conclusion:

Loss of functional teeth and functional occlusal units (especially in the premolar region) were associated with increased cognitive impairment.
Patients with the Subcortical Small Vessel Type of Dementia Have Disturbed Cardiometabolic Risk Profile
Authors: Axelsson Elin , Wallin Anders , Svensson Johan
Published: January 2020

Background:

Population-based studies have shown that cardiometabolic status is associated with the amount of white matter hyperintensities (WMHs) on magnetic resonance imaging (MRI). However, little is known of cardiometabolic risk factors in the subcortical small vessel type of dementia (SSVD), in which WMHs are one of the most prominent manifestations.

Objective:

To determine whether the profile of cardiometabolic risk factors differed between SSVD, Alzheimer’s disease (AD), mixed dementia (combined AD and SSVD), and healthy controls.

Methods:

This was a mono-center, cross-sectional study of SSVD ( n = 40), AD ( n = 113), mixed dementia ( n = 62), and healthy controls ( n = 94). In the statistical analyses, we adjusted for covariates using ANCOVA and binary logistic regression.

Results:

The prevalence of hypertension was increased in SSVD and mixed dementia ( p < 0.001 and p < 0.05 versus controls, respectively). Diabetes was more prevalent in SSVD patients, and body mass index was lower in AD and mixed dementia, compared to the controls (all p < 0.05). Serum total cholesterol (TC) and low-density lipoprotein-cholesterol (LDL-C) were reduced in the SSVD group (both p < 0.05 versus control). These differences remained after adjustment for covariates. In the SSVD group, Trail Making Test A score correlated positively with systolic blood pressure, mean arterial pressure, and pulse pressure.

Conclusion:

All dementia groups had an altered cardiometabolic risk profile compared to the controls. The SSVD patients showed increased prevalence of hypertension and diabetes, and in line with previous population-based data, TC and LDL-C in serum were reduced.
Do not jail my app: Detecting the Android plugin environments by time lag contradiction
Authors: Wu Yifang , Huang Jianjun , Liang Bin , Shi Wenchang
Published: January 2020

Many Android apps today face problems such as the large application package (APK) size, frequent updates, and so on. The Android plugin technology provides a solution for app developers, allowing a running app to dynamically load and execute a separate APK file without installing it in the system. These dynamically loaded APKs are called plugins. In Android app markets, many multi-instance apps abuse this technology to load normal social apps as plugins. While satisfying the users’ demand for logging into multiple accounts simultaneously, it brings new security threats to the legitimate apps. Sensitive API invocations can be hijacked and private data becomes accessible to malicious multi-instance apps. Therefore, identifying the running environments becomes necessary. In this paper, we propose a novel detection mechanism, named PluginAssassin, to identify whether an app is running as a plugin. PluginAssassin uses the time ratio of different activity launching procedures to determine the running environment, conforming to the observed time lag contradiction phenomenon. We also present a mitigation mechanism for the [Formula: see text] attack specific to our approach. We collect 50 multi-instance apps from two app markets and implement PluginAssassin in five popular social apps. We assess the effectiveness on three devices and the experimental results show that PluginAssassin can detect plugin environments effectively.
Characterizing Enrollment in Observational Studies of Duchenne Muscular Dystrophy by Race and Ethnicity
Authors: Barnard Alison M. , Riehl Samuel L. , Willcocks Rebecca J. , Walter Glenn A. , Angell Amber M. , Vandenborne Krista
Published: January 2020

Observational research benefits from inclusion of diverse cohorts. To characterize racial and ethnic diversity in observational and natural history research studies of Duchenne muscular dystrophy (DMD), highly cited and influential observational studies were identified. Fourteen United States-based articles were included. All studies cited >70% White participants with the majority having few racial minority participants. Enrollment of Black/African American individuals was particularly limited (<5% in all but one study), and Hispanic/Latino participants ranged from 3.3– 26.5% of cohorts. These results suggest a need for effective strategies to recruit, enroll, and retain racially and ethnically diverse populations into observational research in DMD.
Management of abdominal distension in the preterm infant with noninvasive ventilation: Comparison of cenit versus 2x1 technique for the utilization of feeding tube
Authors: Cordero González G. , Valdés Vázquez N.O. , Izaguirre Alcántara D.D. , Michel Macías C. , Carrera Muiños S. , Morales Barquet D.A. , Fernández Carrocera L.A.
Published: January 2020

BACKGROUND:

Preterm infants are fed by orogastric / nasogastric tube until they reach maturation and coordination of sucking, swallowing and respiration at approximately 32–34 weeks of corrected age. While being on non-invasive ventilation (NIV), they frequently present abdominal distension. Currently at our institution two techniques are used for the management of abdominal distension in preterm infants fed by bolus via orogastric tube: cenit and 2 x 1.The aim of this study was to compare the proportion of preterm infants presenting NIV-associated abdominal distension with each of these techniques.

STUDY DESIGN:

We conducted a randomized clinical trial including infants of <  36.6 weeks of gestation and <  1500 g of birth weight who were admitted to our NICU during the period of April 1, 2016 to April 1, 2018 and received NIV. The presence of abdominal distension >  2 cm was the primary outcome. Secondary outcomes were presence of reflux, regurgitation, oxygen saturation during feeding and days to reach full feedings. Feeding tube drainage, stool characteristics and the use of prokinetics were confounding variables.

RESULTS:

A total of 97 patients were included. Forty-six in the cenit group and 51 in the 2 x 1 group. There was no difference in the proportion of infants with abdominal distension >  2 cm between groups. Oxygen saturation during feeding at volume of 150 ml/kg/day was higher in the cenit group with statistical significance.

CONCLUSION:

The use of cenit or 2 x 1 technique in preterm infants with NIV did not improve abdominal distension or other indicators of feeding tolerance.
High penetration X-ray communication under physical shielding
Authors: Mu Junxu , Tang Xiaobin , Liu Yunpeng , Hang Shuang , Li Huan , Zhou Wei , Dang Peng , Lai Sheng
Published: January 2020

BACKGROUND:

Modern industrial facilities urgently need effective wireless communication technology to monitor instruments and equipment, but electromagnetic interference and physical shielding often exist in these fields, thereby preventing traditional communication methods from working correctly.

OBJECTIVE:

As a special wireless optical communication technology, X-ray communication (XCOM) is expected to solve the problem of signal transmission under this extreme condition. Our goal was to prove the feasibility of XCOM for signal transmission under metal barrier condition.

METHODS:

The Monte Carlo method was used to simulate the transmission characteristics of X-ray beam under metal barrier conditions, and the communication performance of XCOM was evaluated. Moreover, the experimental demonstration system of XCOM was developed to test the penetration and communication performance of XCOM under metal shield.

RESULTS:

X-ray with energy above 150 keV could achieve a bit error rate of less than 10–4 after passing through a 20 mm iron, whereas X-ray with energy above 250 keV could maintain excellent communication performance after passing through a 30 mm iron. The experimental test results were consistent with the theoretical calculation.

CONCLUSIONS:

As a new wireless optical communication technology, X-ray communication is expected to solve the problem of signal transmission under physical shielding conditions.
PRODUÇÃO DO CONHECIMENTO EM SEXUALIDADE E GÊNERO NAS CIÊNCIAS SOCIAIS NO BRASIL: UM BALANÇO DOS SIMPÓSIOS DE PESQUISAS PÓS-GRADUADAS DA ANPOCS
Authors: Santos Émerson Silva , Sales Ronaldo Laurentino de
Published: January 2020

As ciências sociais têm contribuído de forma significativa para o adensamento dos debates em torno de questões relacionadas à sexualidade e gênero no Brasil, através do desenvolvimento de um amplo conjunto de estudos que apresentam uma rica diversidade conceitual e metodológica. Dentro desse contexto, este trabalho teve por objetivo identificar o perfil das pesquisas de sexualidade e gênero produzidas em programas de pós graduação no Brasil e socializadas nas reuniões anuais da Associação Nacional de Pós-Graduação e Pesquisa em Ciências Sociais (ANPOCS). Em termos metodológicos, o levantamento foi delimitado ao Simpósio de Pesquisas pós Graduadas (SPG) “Sexualidade e Gênero”, realizado nas reuniões anuais da ANPOCS no período entre 2013 (ano de sua criação) e 2018. Um total de 23 artigos foram analisados a partir de uma abordagem qualitativa. Os resultados da investigação apontam que o SPG citado tem privilegiado a apresentação de pesquisas realizadas a partir de um enfoque antropológico, em relação a pesquisas desenvolvidas nos campos da sociologia e da ciência política. Também há uma nítida preferência por pesquisas desenvolvidas em programas de pós graduação localizados na região sudeste do Brasil e de pesquisas que tratam de questões mais relacionadas ao debate em torno das sexualidades.
The essence and implementation of the organizational and economic mechanism management of agricultural enterprises: theoretical aspect
Authors: Farvazova1 E.
Published: January 2020

Abstract. Purpose. The study of the concepts of organizational and economic mechanism of management of agricultural enterprises, methodological approaches to its structure and evaluation of implementation. Methods. The views of domestic and foreign scientists on the content, composition and evaluation of indicators of the organizational and economic mechanism are analyzed. In the course of theoretical and methodological research, a systematic approach was applied using methods of comparative analysis, graphical, abstract-logical, methods of comparison, analogy and generalization. Results. Based on the consideration and synthesis of the concepts of the model study of organizational-economic mechanism, as well as their own conclusions, the proposed elements of the mechanism of agricultural enterprises where the central place is occupied by the state regulation and support of agrarian sector, and also included an additional element – the digitalization of the industry. Comparing positions of scientists concerning the analysis of realization of the mechanism of managing, the author draws a conclusion concerning existence of the indicators characterizing only a financial condition and stability of the agricultural enterprises which concern an organizational and economic component of the mechanism. The scientific novelty consists in the correction of the diagnostic model of the organizational and economic mechanism, according to which the integral indicator of the efficiency of the economic mechanism is calculated on the example of agricultural enterprises and organizations of the Zauralya. The study of the elements and the proposed assessment model of the organizational and economic mechanism of management are the subject to a single goal-competent adjustment of the mechanism levers by both state bodies and economic entities themselves for the successful development of farmers in modern economic conditions.
The Contribution of Major Histocompatibility Complex Class II Genes to an Association with Autoimmune Diseases
Authors: Zakharova M. Yu. , Belyanina T. A. , Sokolov A. V. , Kiselev I. S. , Mamedov A. E.
Published: January 2020

Genetic studies of patients with autoimmune diseases have shown that one of the most important roles in the developing of these diseases is played by a cluster of genes of the major histocompatibility complex (MHC), as compared with other genome areas. Information on the specific contribution of MHC alleles, mostly MHC class II ones, to the genetic predisposition to autoimmune diseases is crucial for understanding their pathogenesis. This review dwells on the most relevant aspects of this problem: namely, the correlation between carriage of certain MHC II alleles and an increased (positively associated allele) or reduced (negatively associated allele) probability of developing the most common autoimmune diseases, such as type 1 diabetes, rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, autoimmune thyroiditis, etc. The most universal haplotypes, DR3-DQ2 and DR4-DQ8, are positively associated with many of these diseases, while the universal allele HLA-DRB1*0701 is protective.
Calcitonin Gene-Related Peptide and Substance P As Predictors of Venous Pelvic Pain
Authors: Gavrilov S. G. , Vasilieva G. Yu. , Vasiliev I. M. , Efremova O. I.
Published: January 2020

The purpose of this work was to study the contents of calcitonin gene-related peptide (CGRP) and substance P (SP) in the blood plasma of patients with pelvic varicose veins. Thirty women with pelvic varicosities and a reflux blood flow were investigated using duplex ultrasonography. Group 1 included 18 patients with clinical signs of the pelvic congestion syndrome (PCS), including venous pelvic pain (VPP). Group 2 consisted of 12 patients with pelvic varicosities with no clinical signs of PCS. Group 1. The score of VPP intensity ranged from 4 to 8; the mean score being 4.84 0.43. The CGRP level in the studied group ranged from 0.39 to 1.01 ng/mL; the SP level ranged from 0.005 to 1.33 ng/mL. Group 2. The CGRP values were 0.15-0.32 ng/mL, and the SP range was 0.003-0.3 ng/mL. In this group, the levels of the studied peptides were 3-5 times lower than those for the patients with VPP. Group 3. The mean CGRP values were 0.06 0.003 ng/mL, and the mean SP values were 0.03 0.001 ng/mL. These values were considered as the reference parameters; a statistical analysis was performed for them. The correlation analysis revealed a strong relationship between the CGRP and VPP levels (r = 0.82) and a medium correlation between the SP level and pelvic pain in Group 1. The CGRP and SP levels in blood plasma highly correlate with the presence of pelvic venous pain.
蓝墨云班课在中职汽车专业教学中的应用实践
Authors: 程 允华
Published: January 2020

为了有效利用手机的学习功能,提高中职汽车专业学生的学习积极性,创造有趣、高效课堂,培养高素质、技能型的汽车专业人才,文章通过对手机APP蓝墨云班课平台的研究,从课前发布教学资源、课堂教学、课后活动三个方面探讨了蓝墨云班课的使用,在教学实践中探索手机与课堂教学模式的有效结合,改变了传统的教学模式和方法,使教学变得轻松、有趣、简单和高效。
新高考背景下一所农村普通高中生涯规划教育的实践性探索
Authors: 尹 红明
Published: January 2020

新高考改革实施伊始,为了保证新高考改革顺利实施,“为每个学生提供适合的教育”,学校开展有效的高中生涯规划教育显得尤为重要,对学生发展具有较强的现实意义。学校要结合实际,着眼学生在高中阶段面临的学习、成长和发展需求,不断探索和开办好高中生涯规划课程,引导学生树立正确的职业观和发展观,帮助学生发展并成就最好的自己,真正落实好生涯规划教育,为党和国家培养有理想、有本领、有担当的时代新人。
信息技术在小学数学课堂教学中的运用
Authors: 何 海成
Published: January 2020

现阶段,随着科技的进步与社会的发展,信息技术在各行各业、各个领域中都得到了广泛而深入的应用,这也在很大程度上影响了人们的学习、生活与工作。在小学数学教学中,合理的应用信息技术,能够有效的提高小学数学课堂教学质量,提升小学生的学习效率。对此,本文主要对信息技术在小学数学课堂教学中的运用策略进行分析,以期为同行交流提供参考与借鉴。
习近平新时代高校生态文明建设的新思路
Authors: 贺 建峰
Published: January 2020

中国特色社会主义新时代下生态文明是实现我国现代化强国的重要组成部分,是满足人民生活物质丰富、生态富饶、和谐美丽的内在需求。大学生是我国社会发展的主要后备力量,高校在生态文明建设中发挥着思想教育阵地和实践基地的引领作用。因此,开展生态文明教育是新时代的要求。本文主要从尊重学生学习主体出发,挖掘高校生态文明教育的新思路,通过知识学习和实践教育多方面丰富了生态文明教育的内涵和形式,提高大学生爱护环境、尊重自然、建设美丽校园的意识和责任感。
Estrutura e padrão de distribuição espacial de umbuzeiro em agroecossistemas do agreste da paraíba
Authors: Torres Ewerton José de Medeiros , Costa Nivânia Pereira da , Barbosa Alex Da Silva , Medeiros Robson Luis Silva de , Silva Ronaldo Costa da , Barbosa Neto Miguel Avelino
Published: January 2020

Estudos que abordem o manejo florestal sustentável na Caatinga ainda são escassos, sendo proporcionalmente o bioma brasileiro menos estudado e protegido. Objetivou-se com este trabalho caracterizar a estrutura e o padrão de distribuição espacial de populações de Spondias tuberosa Arruda de agroecossistemas em microrregiões do Agreste paraibano. Foram plotadas 60 parcelas não contíguas, com 10 m x 10 m dentro de uma área total de 1 km² nos municípios de Soledade e Pocinhos (pertencentes à microrregião do Curimataú Ocidental), e em Solânea e Cacimba de Dentro (Curimataú Oriental). As mensurações de diâmetro da base foram feitas com o auxílio de suta dendrométrica e paquímetro digital, e a altura aferida com o auxílio de tubos de PVC graduados. Os mapas de distribuição espacial em relação ao número de indivíduos por parcela, altura e diâmetro ao nível do solo foram produzidos nos programas Microsoft Office® Excel, SURFER® v. 8 e Corel DRAW® v. X4, que revelaram que as áreas de Soledade e Solânea possuem melhor estado de conservação da espécie, quando comparadas às demais, sendo mais frequentes os indivíduos em recrutamento, ocorrendo maior abundância absoluta por área e possuindo padrão de tendência ao agrupamento. Nas caatingas de Pocinhos e Cacimba de Dentro ocorre ausência de indivíduos regenerantes, sendo encontrados somente indivíduos adultos em estádios ontogenéticos avançados e possuindo padrão de distribuição uniforme. Na caatinga de Soledade há maior densidade absoluta da espécie, e em Pocinhos a menor. Já em termos de frequência absoluta, Solânea detém a maior e Soledade a menor.
Rendimento de grãos de milho segunda safra sob dois regimes hídricos e diferentes sistemas de cultivo
Authors: Garcia Thayná Pereira , Lapaz Allan De Marcos , Nicolai Artur Bernadeli , Okuma Izabella Garbeline , Carvalho Alan Roger Cenerine , Tomaz Rafael Simões , Lima Ronaldo Cintra
Published: January 2020

O grão do milho está entre os cereais os mais produzidos no Brasil. O consórcio entre as culturas de milho e forrageiras do gênero Urochloa visam a produção de grãos e forragem com boa qualidade nutricional para a produção de pastagem ou formação de palha para sistemas de plantio direto (SPD). Este trabalho objetivou avaliar o rendimento de grãos de milho segunda safra sob diferentes sistemas de cultivo do solo em sistema irrigado e não irrigado, no extremo Oeste do Estado de São Paulo. Foi utilizado o delineamento inteiramente casualizado em esquema de parcela subdividida com sete repetições. Os tratamentos foram compostos por combinações de sistemas de cultivo, nas parcelas, com quatro níveis (sistema convencional de preparo de solo; SPD utilizando Urochloa brizantha cv Paiaguás; U. brizantha cv Piatã; e U. ruziziensis cv Ruziziensis), e lâminas de irrigação nas subparcelas, com dois regimes hídricos (não irrigado e irrigado). Independente dos sistemas de cultivo avaliado, o uso da irrigação proporcionou incremento médio de 1045% de rendimento de grãos de milho em relação ao tratamento não irrigado. Além disso, foi verificado maiores estande final e massa seca de palha residual total, proporcionando, assim, maior aporte de palha e benefícios ao SPD para as safras seguintes. Dentre as coberturas vegetais empregadas no SPD consorciada com o milho, as coberturas Paiaguás e Piatã revelaram ser as melhores opções para o consórcio, sob as condições em que foi realizado o experimento, na região do extremo Oeste do Estado de São Paulo.
Custo de produção e análise econômica do abacaxizeiro cultivar ‘pérola’ em Tangará da Serra - MT, Brasil
Authors: Daniel Diego Fernando , Rodrigues Nayara Nunes , Rambo José Roberto , Dalbianco Alessandro Bandeira
Published: January 2020

A estimativa do custo de produção para a região de estudo é de grande importância, pois auxiliará na melhoria das informações sobre a cultura, que posteriormente poderão ajudar os agricultores familiares da região na implantação e condução da cultura, assim complementando a sua renda familiar. O objetivo deste estudo de caso foi realizar a estimativa do custo de produção e a lucratividade da cultura do abacaxi, cultivar Pérola, no município de Tangará da Serra, Mato Grosso. A metodologia utilizada no trabalho é definida por Matsunaga et al. (1976), e descrita por Martin et al. (1998), onde foram determinados o custo operacional efetivo (COE), custo operacional total (COT), receita bruta (RB), lucro operacional (LO), índice de lucratividade (IL), produtividade e preço de equilíbrio. Os valores referentes ao COE e COT, corresponderam respectivamente, a R$19.313,70 e R$20.279,39. Os custos com a adubação (27,99%), aquisição de mudas (25,89%), tratos culturais (11,90%) e colheita (9,86%) foram os maiores gastos observados na produção do abacaxi. Para a comercialização efetiva, o LO da produção de abacaxi foi de R$19.480,61, com receita bruta de R$39.760,00, índice de lucratividade de 49,00% e margem bruta de 96,06%, confirmando a rentabilidade da atividade na região.
Tinjauan Skala Ukuran Perusahaan terhadap Perilaku Entrepreneurial Marketing serta kaitanya dengan Dominasi Dimensi Opportunity dan Growth Orientation
Authors: Utami Christina Whidya , Susanto Hendro
Published: January 2020

This study aims to bridge the gap in the literature by examining the dimensions of Growth Orientation, Opportunity Orientation, Total customer focus dimensions, Value creation Networking, Informal Market Analysis, Closness to The Market on large and small company scale related to Entrepreneurial Marketing (EM) behavior. Thus the objectives to be developed in this study are: analyze how EM behavior in small companies compared to large companies? The dimensions of whether in entrepreneurial marketing are dominant in the context of small and large scale companies. The questionnaire was aimed at a national sample of 406 business owners in Indonesia, spread in 8 provinces. Small companies are defined as companies that employ at least 9 fewer full-time employees other than their owners, while large companies are companies that employ more than 9 full-time employees other than their owners. Snowball sampling is used to determine the selected respondent. The results showed that there are differences in entrepreneurial marketing behavior between large companies and small companies, where small scale companies have lower entrepreneurial marketing behavior compared to large scale companies. For small scale companies, it shows that opportunity orientation is the most dominant dimension, whereas in large scale companies it shows that growth orientation is the most dominant dimension.
Investigating the Effect of Various Fillers on Cohesive Failure Mechanism in Asphalt Mixtures
Authors: Hamedi Gholam Hossein , Sohrabi Mohsen , Sakanlou Farhad , Tahami Seyed Amid
Published: January 2020

In the current research attempts have been made to investigate the effect of various fillers on the resistance to mastic failure using mechanical and thermodynamic methods. Two types of granite and limestone aggregates with acidic and basic characteristics were used, respectively. Besides, four types of filler including calcium carbonate, hydrated lime, Portland cement and stone powder and two types asphalt binder PEN 60-70 and PEN 85-100 were used. Calcium carbonate and hydrated lime had the most effect and Portland cement and stone powder had the least effect on strength reduction. In addition, the results obtained by modified Lottman test showed that the use of hydrated lime and calcium carbonate increased resistance to moisture damage. The results of correlation coefficients show the necessity of using the effect of filler on cohesion free energy calculation in the surface free energy to investigate cohesion failure in different asphalt mixtures.
Strategi Komunikasi Pemasaran RRI Malang dalam Upaya Pencapaian PNBP dan Meningkatkan Jumlah Pengiklan
Authors: Yulius  , Prasetya Widodo Herru
Published: January 2020

RRI Malang as a Public Broadcasting Institution continues to survive amid intense competitions, with the demands to meet the target of achieving Non-Tax State Revenues (PNBP), which rely on the main source of revenue such as advertising but are bound by the Government Regulation No. 5 of 2015. The research aimed to find out how the marketing communication strategy of RRI Malang and the obstacles in implementing the strategy in an effort to achieve Non-Tax State Revenue (PNBP) and increase the number of Advertisers. This research used a descriptive qualitative research method with the data collection obtained from interviews and documents then collected and described. The result showed that the strategies applied by RRI Malang were market opportunity analysis and a competitive analysis which is summarized to an integrated marketing communication (IMC) which included: advertising in the form of price advertising, brand advertising and institutional advertising. A direct marketing through media channels such as catalogs, and telemarketing. The sales promotions were through broadcast programs, general and functional advertisements. The personal selling was through personal face-to-face communication. Furthermore, public relations (branding relations) activities were such as making press releases for each activity and becoming a media partner. The Barriers to the implementation of strategies were the limited funding sources and scope to collaborate with sponsors, advertisement selection was difficult to display discounts, because they were bound by the regulation No.5 of 2015 and lack of Human Resources (HR) and discrepancies between tasks and functions in the field of work.
Strategi Branding Dinas Kebudayaan dan Pariwisata Kota Malang dalam Membentuk Image Sebagai Kota Pariwisata
Authors: Albet Pransiskus , Indra Dewi Sulih
Published: January 2020

This study aimed to find out how the branding strategy of the Culture and Tourism Agency (Disbudpar) of Malang in shaping the image of Malang as a tourism city and to know what obstacles affect the application of the branding strategy. This study used a qualitative research by analyzing the branding strategy of Disbudpar Malang. The data collection techniques carried out in field research and to obtain information and data was through interviews and documentation. The results of this study indicated that the branding strategy of Disbudpar Malang in shaping the image of Malang were as follow, first brand positioning for example by the formation of the beautiful Malang city branding, second brand identity by making the tag line and logo of beautiful Malang, third brand personality for example Malang is known as a cool city, fourth brand communication by promotion on social media events and relationships with stakeholders. The fifth startegy was brand equity for example by making beautiful destinations such as thematic villages and beautiful city parks. The constraints from the brand strategy were first, from the publication of beautiful Malang in print media was considered less reflecting the image of Malang and the presence of those who criticized the beautiful Malang logo, second there were some villages that were still less of awareness in tourism, third in terms of destinations there were lack in facilities and infrastructure, fourth the limited funds to conduct the activities or events.
Integritas Intelektual Menurut Al-Qur’an
Authors: Mahfudzi  Mahfudzi
Published: January 2020

Intellectual Integrity is a combination of literacy, competence, and character. Combining literacy, competence, and character as the fruit of the unification of the head, hand and heart work system through the education process. The conclusion of this research is disagreeing with V. Henry Douglas who states that arrogant actions can only be prevented by literacy and competence, without involving elements of character. Furthermore, this research supports. Residents P Gregg and Nikhila Mahadevan Anthony Gidden's, Paul. F Kniter. Thomas Metjinger. Nasih A. Ulwan. Mohammad Kamal Hasan. Alfred binet and Theodore Simon,. William H. Calvin ,. Al-Mawardi. which states that moral character and performance character contribute greatly to creating unity and are able to prevent various forms of acts of violence and multi-sectoral conflict. The research used is library research and descriptive qualitative analysis with a philosophical approach consisting of linguistic analysis and concept analysis. In this case the concept studied is the concept of Intellectual Integrity according to the quran. Intellectual Integrity is part of the study of ethical philosophy (berten 1993, algermond.black 1993) which is then associated with education. While the main source of this dissertation is the tafsir books of the Qur'an and hadith.
Preventive Effect of L-Carnitine on the Disorder of Lipid Metabolism and Circadian Clock of Mice Subjected to Chronic Jet-Lag
Authors: XIE X. , GUO A. , WU T. , HU Q. , HUANG L. , YAO C. , ZHAO B. , ZHANG W. , CHI B. , LU P. , ZHAO Z. , FU Z.
Published: January 2020

Circadian clock plays an essential role in orchestrating daily physiology, and its disruption can evoke metabolic diseases such as obesity. L-Carnitine can reduce blood lipid levels, and ameliorate fatty liver through regulating lipid metabolism. However, whether L-Carnitine administration may affect the disturbance of lipid metabolism and circadian rhythm of mice induced by prolonged circadian disruption is still unknown. Herein, we investigated the effects of L-Carnitine on conditions of circadian clock and lipid metabolism through a chronic jet-lag mice model which was developed by reversing 12 h light/12 h dark cycle every 4 days for a continuous 12 weeks. Results showed that L-Carnitine administration significantly decreased levels of serum glutamic-oxaloacetic transaminase (GOT) and triglycerides (TG), which were remarkably elevated by chronic jet-lag. More importantly, quantitative real-time polymerase chain reaction (qRT-PCR) analysis indicated that L-Carnitine supplementation would effectively counteract the negative alterations in gene expression which related to lipid metabolism (Srebp1, Acaca, Fasn, and Scd1), metabolic regulator (mTOR) and circadian rhythm (Bmal1, Per1, Cry1 and Dec1) in the liver of mice subjected to the chronic jet-lag. As a conclusion, L-Carnitine was partly effective in preventing the disruption of circadian clock and lipid metabolic disorders induced by the chronic jet-lag.
The Effect of Hypertension on Adult Hippocampal Neurogenesis in Young Adult Spontaneously Hypertensive Rats and Dahl Rats
Authors: PISTIKOVA A. , BROZKA H. , BENCZE M. , RADOSTOVA D. , VALES K. , STUCHLIK A.
Published: January 2020

The dentate gyrus of the hippocampus is one of the few places in the brain where neurogenesis occurs in adulthood. Nowadays, an increasing number of children and young adults are affected by hypertension, one of the factors in the development of cerebrovascular diseases and age-related cognitive deficits. Since these cognitive deficits are often hippocampus-dependent, it is possible that hypertension exerts this effect via decreasing adult neurogenesis which has been shown to be essential for a range of cognitive tasks. We used spontaneously hypertensive rats, which develop hypertension in the first weeks of life. Half of them were treated with the antihypertensive drug captopril. We found that the drug-induced lowering of blood pressure in this period did not affect the rate of adult neurogenesis. In a second experiment, we used another animal model of hypertension – salt-sensitive and salt-resistant strains of Dahl rats. A high-salt diet induces hypertension in the salt-sensitive strain, but not in the salt-resistant strain. The high-salt diet led to salt-induced hypertension, but did not affect the level of adult neurogenesis in the dentate gyrus of the hippocampus. We conclude that hypertension does not significantly affect the rate of hippocampal neurogenesis in young adult rats.
The Effectiveness of Concept Maps for Students’ Learning and Retention
Authors: Collins Brady , Nyenhuis Robert
Published: January 2020

The active learning literature has greatly expanded over the past few years. This article investigates the utility of employing concept map activities in a medium-sized class, and whether or not it improves students’ learning and retention of material. We find that concept mapping activities significantly enhance students’ mastery and recollection of class material. The size of the effect is considerably greater in our treatment group, relative to our control group. We discuss the advantages of this specific active learning technique, and offer suggestions for its incorporation into different institutional settings.
POTENSI PEMBELAJARAN AUDIO DAN RADIO INTERAKTIF DALAM MEMBERIKAN PELAYANAN PENDIDIKAN ANAK USIA DINI DI INDONESIA (SUATU KAJIAN TEORITIS)
Authors: Setiawan Denny
Published: January 2020

Many challenges must be faced by thr GOI in developing the program, nowadays the Govemment of lndonesia (G01) through Early Childhood Education (ECE) Department has been enhancing early childhood education programs for 0 to 8 year old children. The major challenges are children access to early childhood education services and quality of early childhood education programs. Considering the challenges, The United States Agency for Intemational Development (USAID) in partnership with Indonesia's Ministry of National Education is currently implementing a small scale interactive audio instruction (1AI) pilot program targeting 5-6 year olds and their teachers in seven provinces. The program can simultaneously lead acfivities to kindergarten children and teachers as well as train the teachers, who don't have early childhood education background, and how to create high qualityactivities for children. Because of its' simple technology, the program can be applied in various Indonesia district condition, This paper explores the potential role a simple technology can play in assisting the government meet its early childhood education goals and discusses whether something as commonplace as a CD player or radio, when coupled with a proven education methodology, could present a cost effective way to achieving quality at scale.
STRATEGI PENERAPAN DOMAIN AFEKTIF DI LINGKUP PERGURUAN TINGGI
Authors: Soetam Rizky Wicaksono
Published: January 2020

The application of affectiveeducation forcollegestudent cannotbe explicitlydone bylecturers or parents alone, butneeds aspecial strategyin order to havea significant impact on their character development. Based on experience in the relevant fields, the impact of affectiveeducationis oftenoverlookedby teachersand researchersbecause they thoughtthe affectivedomainis verydifficult to measureandhighlydependentonotherfactors. This paperpresents someimplementationstrategiesbased on theaffectivedomain ofliterature reviewtofind astrategy to implementthe affectivedomainforcollegestudent groups. The results ofthis studyis expected tobe afoundation forfutureempiricalresearch.