bluuebunny/crossref_metadata_2025 huggingface dataset:
Ultrasound assisted Fenton-like degradation of dyes using copper doped graphitic carbon nitride
Authors: Wang Chongqing , Huang Rong , Sun Ruirui , Wang Hui
Published: July 2021

A novel copper doped graphitic carbon nitride (Cu-C3N4) was successfully synthesized and used as an effective Fenton-like catalyst. Cu-C3N4 was characterized by scanning electron microscopy, surface area analyzer, Fourier transform infrared spectroscopy, X-ray diffractometer, and X-ray photoelectron spectroscopy. Effect of process parameters including catalyst dosage, hydrogen peroxide (H2O2) concentration, solution pH, and initial methylene blue (MB) concentration was investigated to evaluate catalytic performance. The pseudo first-order kinetic model was used to describe the catalytic process. The enhancement of MB degradation is observed assisted by ultrasound. MB degradation of 96% is obtained within 30 min in Cu-C3N4/H2O2/ultrasound system, and the corresponding rate constant is 0.099 min−1. Effective MB degradation is obtained over a broad pH range (3.3–9.9). The catalytic mechanism is examined by ultraviolet-visible spectra, quenching test, and electron spin resonance determination. The dominant mechanism of MB degradation is ascribed to the ultrasonic H2O2 activation by Cu-C3N4 for hydroxyl radical generation. Cu-C3N4 has good reusability and is effective to degrade rhodamine B and acid orange 7. This work not only contributes to the field of wastewater treatment, but also provides insights into the synthesis of Fenton-like catalysts. The results manifest that Cu-C3N4 is a promising Fenton-like catalyst for dye degradation in the field of environmental pollution remediation.
Structural and Functional Model of Cyberspace
Authors:   Federal State Public Educational Institution of Higher Professional Education Military Telecommunication Academy named after the Soviet Union Marshal Budienny S. M., Starodubtsev Yuri , Zakalkin Pavel ,   Federal State Public Educational Institution of Higher Professional Education Military Telecommunication Academy named after the Soviet Union Marshal Budienny S. M., Ivanov Sergey ,   Federal State Public Educational Institution of Higher Professional Education Military Telecommunication Academy named after the Soviet Union Marshal Budienny S. M.
Published: July 2021

Abstract. The aim of the research is to develop a structural and functional model of cyberspace as an element of its mathematical (analytical and simulation) model, which allows us to study the properties of cyberspace. Formation of the terminological basis of the research area. Research methods: theory of complex systems, synergetics. Research result: a structural and functional model has been developed that describes the process of forming information services based on cyberspace resources. In relation to cyberspace, the concept of “symbiont” is introduced as a universal concept that allows describing any element of cyberspace and its resources. The following terms are defined: cyberspace, information, computing and telecommunications resource. In addition, the formalization of resources and information services provided by cyberspace is presented. An example of forming an information service based on cyberspace resources is shown.
Conflict of Interest Resolution Regulatory Documentation Requirements Analysis in the Context of Information Security
Authors:   Saint-Petersburg National Research University of Information Technologies, Mechanics and Optics, Alekseev Andrei , Vorobeva Alice ,   Saint-Petersburg National Research University of Information Technologies, Mechanics and Optics, Livshitz Ilya ,   Saint-Petersburg National Research University of Information Technologies, Mechanics and Optics, Yurin Igor ,   Saint-Petersburg National Research University of Information Technologies, Mechanics and Optics,   Admiral Makarov State University of Maritime and Inland Shipping
Published: July 2021

Research aim: analysis and assessment of the level of readiness of the requirements for the regulation of conflicts of interest contained in the current standards of the Russian Federation on information security and management systems, for compliance with national legislation, as well as their comparison with the requirements of ISO standards. Research method: a comprehensive analysis of regulating conflicts of interest problem was carried out the regulatory framework of the Russian Federation (273-FZ, Bank of Russia Ordinances No. 5511-U and standards for management systems and information security). The requirements contained in the national standards of the Russian Federation and international ISO standards are analyzed for their mutual correspondence. Results obtained: The research presents the comparison of the requirements of the federal law of the Russian Federation FZ-273 and standards for management systems and information security. Comparative table of requirements for resolving conflicts of interest is presented. The existing software of automated search and analysis of conflicts of interest are analyzed. It is proposed to use of modern automated tools for regulation of conflicts of interest in organizations.
Contraindications Differ Widely Among Beta Blockers and Ought to be Cited for an Individual Drug, Not for the Entire Class
Authors: Koraćević Goran , Stojanović Milovan , Kostić Tomislav , Lović Dragan , Zdravković Marija , Koraćević Maja , Pavlović Dimitrije , Mićić Slađana
Published: July 2021

Beta blockers (BBs) have important side effects that contribute to low adherence and persistence.
Therefore, the optimal choice of BB is an important mode to prevent BB’s side effects, leading to an increase in
compliance, which can improve the outcomes in BBs' evidence-based indications, such as acute myocardial infarction,
heart failure, etc. The aim of the paper is to suggest an improved method of reporting contraindications
for BBs. We used a search of the following indexing databases: SCOPUS and PubMed, and web search engine
Google Scholar to identify guidelines on arterial hypertension (HTN). HTN guidelines published during the last
2 decades were analyzed (from 2000 to 2020). Some of the contraindications (e.g., bradycardia, acute heart
failure) are true for every BB. However, some contraindications do not belong to the whole BB class. For example,
propranolol and carvedilol are contraindicated in chronic obstructive lung disease, but nebivolol and bisoprolol
are not. We suggest that contraindications which are specific for some BBs (i.e., not for the whole
class) ought to be listed with the exact name(s) of the individual BBs. In this way, we may decrease the number
of wrong choices among BBs and consequently increase drug adherence (which is currently worse for the class
of BBs than for most of the other antihypertensive drugs). To our knowledge, there is a lack of guidelines citing
contraindications for individual BBs, because they vary a lot within-the-class of BBs. This is an approach to
improve both basic medical education and guidelines.
Silver-assisted Syntheses of Fused Five-membered N-heterocycles
Authors: Kaur Navjeet , Ahlawat Neha , Verma Yamini , Grewal Pooja , Bhardwaj Pranshu , Jangid Nirmala Kumari
Published: July 2021

:

The metal-mediated formation of heterocycles is one of the most emerging and
important strategies in organic chemistry. The reactions utilized previously for the synthesis of
heterocycles were less familiar to the scientists due to their complicated work-up, expensive
nature, and difficult operations. The silver-assisted cyclic reactions are highly efficient for
both regioselective and stereoselective syntheses of five-membered fused N-heterocyclic compounds.
The applications of silver in the preparation of five-membered fused N-heterocyclic
compounds are covered in this review article.
Identification of a 15 DNA Damage Repair-Related Gene Signature as a
Prognostic Predictor for Lung Adenocarcinoma
Authors: Jian Hong , Gu Linping , Xu Yuanyuan
Published: July 2021

Background:

Lung adenocarcinoma (LUAD) is a common malignancy with a poor
prognosis due to the lack of predictive markers. DNA damage repair (DDR)-related genes are
closely related to cancer progression and treatment.

Introduction:

To identify a reliable DDR-related gene signature as an independent predictor of
LUAD.

Methods:

DDR-related genes were obtained using combined analysis of TCGA-LUAD data and
literature information, followed by the identification of DDR-related prognostic genes. The DDRrelated
molecular subtypes were then screened, followed by Kaplan-Meier analysis, feature gene
identification, and pathway enrichment analysis of each subtype. Moreover, Cox and LASSO
regression analyses were performed for the feature genes of each subtype to construct a prognostic
model. The clinical utility of the prognostic model was confirmed using the validation dataset
GSE72094 and nomogram analysis.

Results:

Eight DDR-related prognostic genes were identified from 31 DDR-related genes. Using
consensus cluster analysis, three molecular subtypes were screened. Cluster2 had the best
prognosis, while cluster3 had the worst. Compared to cluster2, clusters 1 and 3 consisted of more
stage3 - 4, T2-T4, male, and older samples. The feature genes of clusters1, 2, and 3 were mainly
enriched in the cell cycle, arachidonic acid metabolism, and ribosomes. Furthermore, a 15-feature
gene signature was identified for improving the prognosis of LUAD patients.

Conclusion:

The 15 DDR-related feature gene signature is an independent and powerful
prognostic biomarker for LUAD that may improve risk classification and provide supplementary
information for a more accurate evaluation and personalized treatment.
Hepatocellular Carcinoma Targeting and Pharmacodynamics of Paclitaxel Nanoliposomes Modified by Glycyrrhetinic Acid and Ferric Tetroxide
Authors: Zhao Ling , Liang Leyi , Guo Mimi , Li Ming , Yu Xuesong , Wang Ying , Wang Yan
Published: July 2021

Aims:

Research on developing targeted delivery of anticancer drugs for the treatment of
hepatocellular carcinoma (HCC) is ongoing. This study aimed to synthesize nanoliposomes modified
by glycyrrhetinic acid (GA) and ferric tetroxide (Fe3O4) for targeted delivery of paclitaxel for
selective and specific therapy of HCC.

Objective:

During this project, GA and Fe3O4 were used to jointly modify the active targeting and
magnetic orientation of paclitaxel nanoliposomes for enhanced targeting of HCC to improve the efficacy,
while reducing the systemic toxicity and side effects of the drug.

Methods:

In this study, liposomes were prepared utilizing a thin film dispersion method, in which
the average particle size of GA/Fe3O4-PTX-LP was 148.9 ± 2.3 nm, and the average Zeta potential
was -23.2 ± 3 mV. Based on TEM characterization, GA/Fe3O4-PTX-LP is a closed particle with bilayer
membranes. In vitro release assessments of the drug indicated that the release of GA/Fe3O4-
PTX-LP was sustained.

Results:

In vitro cell tests have demonstrated that GA/Fe3O 4-PTX-LP can inhibit the proliferation,
affect the morphology, migration and invasion, and interfere with the cycle of HCC cells. Uptake
tests have confirmed that GA/Fe3O4-PTX-LP can promote the uptake of the drug in HCC
cells.

Conclusion:

In vivo targeting experiments have shown that GA/Fe3O4-PTX-LP has a strong ability
to target tumors. In vivo antitumor assessments have proven that GA/Fe3O4-PTX-LP can inhibit
tumor growth without obvious toxicity. This project provides a promising nano-targeted drug delivery
system for the treatment of HCC.
Flexible Bronchoscopy Biopsy Tools and Techniques to Optimize Diagnostic
Yield: A Contemporary Review
Authors: Ramayanam Snehamayi , Puchalski Jonathan
Published: July 2021

Background:

Flexible bronchoscopy is essential in diagnosing many pathologic conditions,
and tools such as lavage and biopsies using brushes, forceps, and needles are paramount to
success.

Introduction:

Bronchoscopists worldwide are routinely confronted with questions about such tools
regarding the type, size, utility, costs, safety, anticipated yield, and others. Does the underlying suspected
condition matter to the choice of instruments used? What is the anticipated outcome for benign
versus malignant diseases? These and other questions are raised daily by bronchoscopists.

Methods:

Pubmed was reviewed for research in the English language pertaining to diagnostic bronchoscopy.
The literature is conflicting on the benefits of the types of tools available. The success of
brush biopsies, forceps, and transbronchial needle aspiration is only partially dependent on the size
of the instrument used or its other characteristics. Multiple biopsies are needed, and different approaches
may be complementary in some circumstances.

Results:

By understanding the factors that involve in a biopsy, the bronchoscopist is more likely to
be successful when a crucial diagnosis is mandatory.

Conclusion:

This review aims to be a reference to bronchoscopists everywhere as they contemplate
their approach to flexible diagnostic bronchoscopy.
Shared Food, Meals and Drinks: 10 Arguments Suggesting an Oral
Transmission Route of SARS-CoV-2
Authors: Wendling Jean-Michel , Saulnier Aure , Sabatier Jean-Marc
Published: July 2021

:

Numerous observational, epidemiologic data have suggested that the risk of COVID19 is related to shared
meals or drinks. The presence of ACE2 receptors in the gastrointestinal tract supports this hypothesis. Furthermore, several patients experience gastrointestinal symptoms without any respiratory disease. The SARS-CoV-2 found on food and
packaging in China and the epidemic resurgence attributed to foods are also strong indications of an oral transmission
route. Unprecedented biopersistence on skin, food, and beverages supports this theory. Finally, animal models reproducing the disease by oral inoculation are additional arguments in favor of an oro-digestive route of infection.
Young and Middle-aged Adults Differ in Neural Correlate of Sustained Attention: A fNIRS Study
Authors: Shenoy Shweta , Khandekar Prachi , Sathe Abhinav
Published: July 2021

Aims:

The aim of the study was to assess the activation of prefrontal cortex during sustained
attention task in young and middle aged adults using Functional near infrared spectroscopy
system.

Background:

Sustained Attention (SA) is a construct of cognition that tends to decline with age.
There is a paucity of literature regarding the neural correlates of SA in middle age, a link between
young and old age.

Objective:

This study evaluated the differences in SA ability and its neural correlates using fNIRS
between young and middle aged adults.

Methods:

38 young and 25 middle aged adults were evaluated for the changes in neural correlates
(oxy and deoxy haemoglobin concentration in prefrontal cortex) during a SA task known as cognitrone.

Results:

The results obtained showed that young adults performed significantly better than middle
aged adults on the SA task with no gender difference in their performance. There was a significant
difference in the prefrontal activation pattern between young and middle aged adults. We found
right prefrontal dominance in young adults and left prefrontal dominance in middle aged adults.

Conclusion:

This study concludes that the ability to maintain SA diminishes with age, advancing
from young to middle age. Hemodynamic findings confirmed significant differences in neural resources
in the prefrontal cortical areas between young and middle age.
Computational Investigation on the MDM2-Idasanutlin Interaction Using the Potential of Mean Force Method
Authors: Das Pundarikaksha , Mattaparthi Venkata Satish Kumar
Published: July 2021

Background:

The Murine Double Minute 2 (MDM2) protein is a well-studied primary
negative regulator of the tumor suppressor p53 molecule. Therefore, nowadays many research
studies have focused on the inhibition of MDM2 with potent inhibitors. Idasanutlin (RG7388) is a
well-studied small molecule, the antagonist of MDM2 with potential antineoplastic activity. Nevertheless,
the highly significant information pertaining to the free energy profile, intermediates, and
the association of receptor and ligand components in the MDM2-idasanutlin complex remains unclear.

Objective:

To study the free energy profile of the MDM2-idasanutlin complex in terms of the Potential
of Mean Force (PMF) method.

Method:

We have used the PMF method coupled with umbrella sampling simulations to generate
the free energy profile for the association of N-Terminal Domain (NTD) of MDM2 and idasanutlin
along with a specific reaction coordinate for identifying transition states, intermediates as well as
the relative stabilities of the endpoints. We also have determined the binding characteristics and interacting
residues at the interface of the MDM2-idasanutlin complex from the Binding Free Energy
(BFE) and Per Residue Energy Decomposition (PRED) analyses.

Results:

The PMF minima for the MDM2-idasanutlin complex was observed at a center of mass
(CoM) distance of separation of 11 Å with dissociation energy of 17.5 kcal mol-1. As a function of
the distance of separation of MDM2 from idasanutlin, we also studied the conformational dynamics
as well as stability of the NTD of MDM2. We found that there is indeed a high binding affinity
between MDM2 and idasanutlin (ΔGbinding = -3.19 kcal mol-1). We found that in MDM2, the residues
MET54, VAL67, and LEU58 provide the highest energy input for the interaction between
MDM2 and idasanutlin.

Conclusion:

Our results in this study illustrate the significant structural and binding features of the
MDM2-idasanutlin complex that may be useful in the development of potent inhibitors of MDM2.
Modelo de cultura organizacional para el desarrollo de la calidad en instituciones de educación superior
Authors: Llanos Encalada Mónica del Pilar
Published: July 2021

El libro que se presenta tiene como finalidad mostrar un estudio sobre la cultura organizacional y su vínculo con la calidad en instituciones de educación superior. A partir de este estudio que propone un modelo de Cultura Organizacional para una institución de educación superior ecuatoriana, lo cual afianza el criterio del vínculo real que existe entre la cultura y la calidad, y se refuerza la idea de la urgencia de alcanzar mejores prácticas en los procesos académicos.
Realidades de los modelos de emprendimientos en los recintos del Cantón Samborondón
Authors: Llanos Encalada Mónica , Llanos Encalada Mónica del Pilar , Armas Ortega Yadira Mariuxi , Bravo García Martha Karina , Ron Amores Rafael Eduardo
Published: July 2021

El presente libro es el resultado del proyecto de investigación “Modelos de emprendimiento en los recintos de la zona rural del cantón Samborondón” a partir del cual se puede reflexionar sobre las realidades del sector rural en referencia al sector urbano. La investigación parte del estudio de campo involucrando a los actores (miembros de la comunidad), lo cual permite, identificar, por un lado, las necesidades de la población de los recintos del cantón Samborondón y, por otro, las oportunidades de apoyo a través de las habilidades de los miembros de la comunidad. Es importante mencionar, que los modelos de emprendimiento propuestos desde una visión externa no siempre son la respuesta, pues en su mayoría no corresponden con las realidades que vive la población. Por lo cual, en el transcurso de la investigación se evidenció varios limitantes y como punto central las características disímiles entre las diferentes zonas que conforman el Cantón y constituyen brecha para el desarrollo de los recintos.
La creatividad en el territorio
Authors: Vergara-Romero Arnaldo , Márquez-Sánchez Fidel , Coronado Blum Katherine , Sorhegui Ortega Rafael , Baidal Chang Stefania
Published: July 2021

En el último quindenio, el concepto de economía creativa ha ganado popularidad en el ámbito gubernamental, académico y empresarial, ya que ven el potencial de desarrollo económico en el desarrollo de la creatividad y la propiedad intelectual. La creatividad también se está convirtiendo en una fuente de valor económico. En este sentido, la relación entre el desarrollo de la economía creativa y la innovación es de especial interés. Se evidencia periodos de cambio estructural a nivel global en economías caracterizadas por un crecimiento constante de las industrias creativas como fuente de empleo, exportaciones y valor agregado. Mediante el concepto de economía creativa se extiende el paradigma para el futuro de la economía y el futuro de la sociedad en su conjunto, y la creatividad combinada con el conocimiento se considera el recurso económico más importante del mundo con una población en crecimiento.
Las tradiciones el arte y la cultura de Ecuador
Authors: Jalón de Torbay Alicia , Cabal Plaza Katherine , Castro Torre Fátima , Armanza Astudill Julio , Del Pozo Raymond Víctor Hugo , Solis Muñoz Juan Bautista , García Álvarez Florencio Iván , Rodríguez Oswaldo Ramiro , Ormaza Andrade Jorge Edwin , Manner Baldeon Fanny , Carvache Franco Mauricio , Carvache Franco Wilmer
Published: July 2021

La cultura de Ecuador es rica en tradiciones, así como en expresiones artísticas, aunque estas manifestaciones estuvieron ignoradas por el mundo, hasta inicios del siglo XX, cuando se descubren, se valorizan y se consideran muchas manifestaciones integradas al patrimonio universal. En época reciente, más concretamente en el siglo XX, se valora nacional e internacionalmente la producción de los artistas plásticos ecuatorianos. Pero no sólo la plástica produce obras, sino que el sentimiento ecuatoriano crea un género musical importante, lleno de melancolía, conocido como pasillo ecuatoriano, género que también se dio en otras latitudes regionales y que alcanzó gran popularidad durante buena parte del siglo XX y tuvo intérpretes ecuatorianos que alcanzaron fama internacional y han quedado convertidos en verdaderos íconos del sentir popular. Dentro de la riqueza cultural que posee el País, se hacen evidentes las manifestaciones populares andinas, como son las fiestas que se realizan en homenaje al sol, recordando las costumbres ancestrales de agradecer por las cosechas y que son parte del patrimonio ecuatoriano. Este libro compila los trabajos investigativos tendientes a mantener el interés por las tradiciones ancestrales de Ecuador, tanto en su producción artística, como en sus manifestaciones folklóricas más importantes, así como valorar la importancia para el turismo de un importante sitio histórico. Se compilan en este libro los cuatro mejores trabajos de investigación que se presentaron en el área de Turismo, Hospitalidad y Patrimonio en el III Congreso Científico Internacional “Sociedad del Conocimiento: Retos y Perspectivas”.
Development of an Efficient Bi-Functional Catalyst made of a Novel Hybrid Material for Rechargeable Zn-Air Battery
Authors:   Faculty of Chemistry and Center for NanoIntegration (CENIDE), University of Duisburg-Essen, Essen 45117, Germany, Wang Shiping , Bendt Georg , Schulz Stephan ,   Faculty of Chemistry and Center for NanoIntegration (CENIDE), University of Duisburg-Essen, Essen 45117, Germany
Published: July 2021

One-pot synthesis of mesoporous hybrid material consisting of Mn-Co/CoO nanoparticles encapsulated in an N-doped graphene shell decorated with Mo2C nanoparticles (Mo2C-NC@Mn-Co/CoO) was reported. The Mn and Mo components synergistically refined the graphitized carbons due to the interactions with N and C atoms while promoting the stability of the Co/CoO nanoparticles. These components exhibited a beneficial effect on the dispersion of the active metal/metal oxide nanoparticles and the formation of a mesoporous structure under high-temperature conditions, which together led to optimized oxygen adsorption/desorption capabilities as well as mass transport properties. The hybrid material showed high bifunctional performance for both oxygen evolution reaction (OER) and oxygen reduction reaction (ORR), as well as promising catalytic properties as the air electrode in a zinc-air battery, featuring superior long-term cycle stability comparable to that of Pt-C/RuO2 materials.
Suitability of Steel Making Slag as a Construction Material Resource
Authors:   Energy Safety Research Institute (ESRI), Swansea University, Bay Campus, Swansea SA1 8EN, UK, Fisher Lucy V. , Barron Andrew R. ,   Energy Safety Research Institute (ESRI), Swansea University, Bay Campus, Swansea SA1 8EN, UK,   Institute of Resilience, Rice University, Houston, Texas 77005, USA,   Faculty of Engineering, Universiti Teknologi Brunei, Brunei Darussalam,   Arizona Institute of Resilience (ARI), University of Arizona, Tucson, Arizona 85719, USA
Published: July 2021

One of the largest problems facing the steelmaking industry is the high amount of waste currently produced and the low amount of waste that is currently recycled. This study aims to look at the suitability of 3 different samples of basic oxygen steelmaking (BOS) slag as a construction material, in concert with their carbon capture capacity. Characterization by scanning electron microscopy (SEM), X-ray diffraction (XRD), inductively coupled plasma spectroscopy (ICP), X-ray fluorescence (XRF), CO2 adsorption analysis, and thermogravimetric analysis (TGA) demonstrated that these BOS slags were found to have several favorable characteristics making them suitable for reuse as construction material.
Impact of Collective Trademarks in Mexican artisanal cheesemakers
Authors: Agudelo-López Mónica Andrea , Cervantes-Escoto Fernando , Cesín-Vargas Alfredo , Palacios-Rangel María Isabel , Espinoza-Ortega Angélica
Published: July 2021

Processes related to Collective Trademarks (CTMs), and the state of social friendship, productive support, and strategic networks, were studied for three different artisanal cheesemaker groups: Queso Bola de Ocosingo with an inactive CTM, Queso de Poro de Balancán, with an active CTM, and Quesillo de Reyes Etla, with a CTM undergoing its negotiation process. The influence of negotiation and operation of CTMs as consolidation strategies of three Mexican artisanal cheesemakers was analyzed through a mixed investigation involving in-depth interviews, social network analysis, and quantitative information. The research indicated that networks are small with scarce interaction among the actors, and, where collective strategies have not been induced, the networks are more disconnected and show a higher proportion of isolated nodes. It is concluded that, when collective strategies come from external actors without the necessary accompaniment, they tend to fail because their actions are supported by temporal actors, impacting social relations among cheesemakers.
Estimación de la heredabilidad del intervalo entre partos en bovinos Romosinuano mediante el modelo lineal mixto generalizado
Authors: Santana Rodríguez Martha Oliva , Ossa Saraz Gustavo Alfonso , López Martínez Jorge Leonardo , Hernandez Barajas Fredy , Garcés Blanquiceth Jorge Luis
Published: July 2021

El objetivo de este estudio fue estimar el valor de heredabilidad del carácter intervalo entre partos en una población de 2.112 vacas Romosinuano, y determinar los factores responsables de la variación de este carácter mediante el modelo lineal mixto generalizado. Se analizaron 7.560 registros de intervalo entre partos en el periodo 1936-2016. La media del intervalo entre partos fue de 379,74 ± 49,22 días (CV = 12,96 %) y las clases mes de parto, número de intervalo entre partos y año de parto tuvieron un efecto estadísticamente significativo sobre este carácter. Los menores intervalos entre partos ocurrieron entre abril y junio (367,12 ± 46,06 días), en vacas de cuarto y quinto parto (373,93 ± 46,93 días), y entre los años 1956 y 1965 (370,48 ± 50,55 días). Los mayores valores se presentaron entre octubre y diciembre (388,92 ± 57,96 días) en vacas de segundo (389,70 ± 49,38 días) y tercer intervalo entre partos (382,18 ± 51,19 días) cuyo parto ocurrió en el periodo 1946-1955 (387,69 ± 56,75 días). La heredabilidad de este carácter fue de 0,0001 ± 0,002. Se concluye que la raza Romosinuano tiene eficiencia reproductiva; sin embargo, dada la baja heredabilidad del intervalo entre partos, la selección por este carácter tendrá un impacto relativamente bajo debido al efecto de factores ambientales sobre su variación. El modelo lineal mixto generalizado es una herramienta que permite este tipo de estudios.
Privacy Concerns regarding Open Medical Data (Preprint)
Authors: Li Jingquan
Published: July 2021

UNSTRUCTURED

With next-generation sequencing (NGS), it is now feasible to sequence large amounts of DNA and publish comprehensive individual genome-phenome data sets for genome-wide association studies. The Personal Genome Project (PGP) is a collaborative research initiative that aims to sequence and publicize the complete genomes and medical records of 100,000 volunteers, in order to enable NGS into personal genomics and personalized medicine. The PGP puts genome data in an open medical database on the Internet to promote studies by many researchers and citizen scientists. However, open medical data pose significant privacy and ethical issues because it can convey identifiable and predictive information concerning particular individuals and their family members and relatives. The purpose of this paper is to identify the most important privacy and security risks of open medical data and explain how to use data protection and privacy policies to handle the risks. This paper begins by detailing the growth of genetic testing and the characteristics of genomic data. We then present the case study of the PGP’s open medical data and open consent model and highlight how open medical data could raise important questions regarding privacy and confidentiality of genomic and personal data. We further propose privacy policy considerations to resolve these challenging privacy concerns. We conclude with a discussion of the implications of the study and directions of future research.
Online Search Behavior Related to COVID-19 Vaccines: Infodemiology Study (Preprint)
Authors: An Lawrence , Russell Daniel M , Mihalcea Rada , Bacon Elizabeth , Huffman Scott , Resnicow Ken
Published: July 2021

BACKGROUND

Vaccination against COVID-19 is an important public health strategy to address the ongoing pandemic. Examination of online search behavior related to COVID-19 vaccines can provide insights into the public's awareness, concerns, and interest regarding COVID-19 vaccination.

OBJECTIVE

The aim of this study is to describe online search behavior related to COVID-19 vaccines during the start of public vaccination efforts in the United States.

METHODS

We examined Google Trends data from January 1, 2021, through March 16, 2021, to determine the relative search volume for vaccine-related searches on the internet. We also examined search query log data for COVID-19 vaccine-related searches and identified 5 categories of searches: (1) general or other information, (2) vaccine availability, (3) vaccine manufacturer, (4) vaccine side-effects and safety, and (5) vaccine myths and conspiracy beliefs. In this paper, we report on the proportion and trends for these different categories of vaccine-related searches.

RESULTS

In the first quarter of 2021, the proportion of all web-based search queries related to COVID-19 vaccines increased from approximately 10% to nearly 50% of all COVID-19–related queries (P<.001). A majority of COVID-19 vaccine queries addressed vaccine availability, and there was a particularly notable increase in the proportion of queries that included the name of a specific pharmacy (from 6% to 27%; P=.01). Queries related to vaccine safety and side-effects (<5% of total queries) or specific vaccine-related myths (<1% of total queries) were uncommon, and the relative frequency of both types of searches decreased during the study period.

CONCLUSIONS

This study demonstrates an increase in online search behavior related to COVID-19 vaccination in early 2021 along with an increase in the proportion of searches related to vaccine availability at pharmacies. These findings are consistent with an increase in public interest and intention to get vaccinated during the initial phase of public COVID-19 vaccination efforts.
Accounting for Change in IR
Authors: Ng K.H. Esther
Published: July 2021

Most theories of International Relations (IR) are cautious, if not pessimistic, about the potential for change in IR. In this regard, the concept of ontological security holds promising yet oft-overlooked prospects. This article argues that applications of ontological security to IR theory thus far have been limited due to the narrow conceptualisations of practices and how they contribute to one’s attempts to preserve their ontological security. As such, this paper seeks to expand the theoretical framework through which ontological security is applied to IR, which involves a more comprehensive conceptualisation of practice that considers reflexivity as key. Accordingly, the theory demonstrates that a state, faced with threats to their sense of Self, can respond either by rigidising or changing their practices rather than being limited to the former. This allows one to account for change—especially big change—in world politics such as the increasingly inward-looking turn of the West.
Steroid switching in dystrophinopathy treatment: a US chart review of patient characteristics and clinical outcomes
Authors: Marden Jessica R , Santos Claudio , Pfister Brian , Able Richard , Lane Henry , Somma Michael , Zhao Jing , Signorovitch James , Parsons Julie , Apkon Susan
Published: July 2021

Aim:
To describe reasons for switching from prednisone/prednisolone to deflazacort and associated clinical outcomes among patients with Duchenne and Becker muscular dystrophy (DMD and BMD, respectively) in the USA.
Methods:
A chart review of patients with DMD (n = 62) or BMD (n = 30) who switched from prednisone to deflazacort (02/2017–12/2018) collected demographic/clinical characteristics, reasons for switching, outcomes and common adverse events.
Results:
The mean ages at switch were 20.1 (DMD) and 9.2 (BMD) years. The primary physician-reported reasons for switching were ‘to slow disease progression’ (DMD: 83%, BMD: 79%) and ‘tolerability’ (67 and 47%). Switching was ‘very’ or ‘somewhat’ effective at addressing the primary reasons in 90–95% of patients.
Conclusion:
Physician-reported outcomes were consistent with deflazacort addressing patients' primary reasons for switching.
Power Generation by Revolving Door
Authors: Suryawanshi Omkar
Published: July 2021

As the world move forward in various fields like research and development; conservation of energy is a major issue to be resolved. To meet load demand, renewable energy and some unconventional source of energy can provide the necessary amount of clean energy for atmosphere stabilization and scale down the consumption of fossil fuel. Due to shortage of power in the rural areas as well as developing cities saving of energy is a vital factor so we have to save the energy whenever as possible. In this paper, prospect and usefulness of “Power Generation by using Revolving Door” has been reviewed. The objectives of this paper is to designed fabricated of a miniature revolving door which can generate energy by amplifying the initial RPM of door shaft that harnesses human motion and change it as electricity.
Disease Analysis Using Medicines’ Sales Data
Authors: Mohite Mr. Omkar S.
Published: July 2021

The medical industry is one of the vast organized industries, which deals with various kinds of health-related products and services. Additionally, this industry also contributes in Research and Development of Medicines to cure diseases. Hence, they also have their sales data for a particular area, using some kind of aggregation, predication and clustering we can use the sales, association data for finding the outbreak of a daisies or we can check the sales of that particular area and demand for a particular medicine. Using this data, we can make some precautionary measures on that area plus we can analyze the effectiveness of the particular medicine. Plus, this data helps in the Research and Development of new medicine. The medical industry is one of the vast organized industries, which deals with various kinds of health-related products and services. Additionally, this industry also contributes in Research and Development of Medicines to cure diseases. One of the important aspects of every organization is the Sales, this industry too has different sales data for every particular area. With the help of aggregation, prediction and clusters we can use the sales data associated with medicines to find outbreak of any disease or we can verify sales of any particular area and look at the demand for a particular medicine. Using this data, we can take early precautionary measures in those areas, also we can analyze the effectiveness of that particular medicine. This new kind of data will be beneficial for Research and Development of new medicines.
Heart Attack Prediction Using Arduino
Authors: Yadav M. Sai Kiran
Published: July 2021

Nowadays several folks are mislaying their lives because of coronary heart assault and absence of clinical interest to affected person at accurate level. Hence, on this mission we're imposing coronary heart assault prediction device with the use of Arduino. The first level of coronary heart assault is surprising change in coronary heart beat. Suddenly it is going too excessive or too low. At this level we predict the coronary heart assault by the means of an Arduino and a coronary heart beat sensor, then will inject drug into the body, by means of controlling vale or pump which can be positioned at the center of drug hose. Now controlling coronary heart assault is quicker less difficult and predictable. In this mission coronary heart beat sensor can be connected to affected person's body and ship the coronary heart beat to the Arduino. Now it assesses the values and if the values aren’t always regular then the step motor that manage the drug will rotate and will increase the drug flow. For controlling the quantity of drug to be injected to an affected person's body, we use a step motor.
Design and Development of a Smart Seat for Relieving from Pressure Ulcers
Authors: Tembhurne Er. Rohit
Published: July 2021

The long-term effects of sitting in a wheelchair/chair can be painful. People who use wheelchairs/chair can get muscle deformities and even serious injuries. Wheelchair/chair injuries and pains, such as pressure ulcers, normally hit people who spend a significant amount of time in wheelchairs. Bad posture is another major challenge for people who use wheelchairs/chair because they are not able to change their sitting position.
Table Reservation and Meal Ordering System Using QR Code
Authors: Arora Aman
Published: July 2021

At present, people have been waiting anxiously for the system that will satisfy their needs more clearly. The majority of the companies in the restaurant sector is looking for some software that improves the quality of delivery and increasing revenue. In a typical system, the waiter records the customer's order, and then put the order in to the kitchen, and then billing is done, which spends a lot of time and might lead to errors. The goal of this project is to automate the process of ordering food from the table in a restaurant and reserving a table, as well as to improve the quality of their customer service. Smart Restaurant is a concept of a restaurant's business that is based on the use of state-of-the-art technology from reservation to the order and the customer sign a relationship with you. The traditional restaurant will be replaced with the help of a smartphone, a tablet, or a graphical user interface and interactive touch screens. Customers will have to order their food via mobile phones by scanning a QR code on a table, as they are directly linked to the kitchen via a central server. In addition, our records are permanently stored on a central server, which can then be used for the marketing, distribution and sales. A smart restaurant, decrease the number of staff who work at the hotel-services, so as to increase the profit margins. The kitchen is going to be one of the interfaces which will be provided in accordance with the following priority (first-come-first-served). This app will help you to find more detailed information on the restaurant and its services, as well as the ease of ordering food and reservation table.
Analysis of BIM (Building Information Modelling) by Using 7D
Authors: Pol Somesh
Published: July 2021

Today's construction stakeholders don't care about the elegance of the building information model (BIM). They ensure that the building is completed on time and minimize overruns or errors. Traditionally, BIM has been used as a design tool in architecture, engineering, and construction. (AEC). Expertise in building and infrastructure planning and construction. But beyond BIM, there is more to consider. The construction process integrates the entire life cycle of the building to manage construction work, teamwork and overall productivity. Project management model and engineering model are on a collaborative platform. Data from different sources can be combined and used to make more informed decisions before and after construction. This integrated process helps all relevant personnel to fully understand the project so that they can coordinate before this data-driven process also provides relevant personnel with analysis and business intelligence. You can not only build trust, but also optimize the entire business process and procedures and operation.
Increasing Ground Water Level by Penetrating Surface Runoff
Authors: Mandlik Prof. D. N
Published: July 2021

System proposed in this paper is the planned filtrating penetration system to harvest the surface runoff like storm water into our designed unit in order to increase the natural level and replenishment of ground water resources. Ground water recharge is increasing in popularity as ground water resources are being depleted due to excess of water extraction of water from boreholes in the urban areas. Although the primary objective of this technology is to preserve or increase ground water resources, this kind of artificial recharge has been used for many other beneficial purposes. These include additional treatment (through soil filtration) and conservation or disposal of treated wastewater or floodwaters, storage of water to reduce pumping and piping costs as well as temporary regulation of ground water abstraction. Furthermore water quality can be improved through the removal of suspended solids via soil filtration (see also aquifer treatment) or through the dilution with naturally occurring ground water.
Modelling and Analysis of On-Site Emergency Plan of a Major Accident Hazard in a LPG Bottling Plant
Authors: Shokeen Rishabh
Published: July 2021

As an organization there is a range of responsibilities and legislation that require you to have a plan to ensure the safety of employees, customers and stakeholders who may be on site when an emergency occurs. Equally important is the ability of facility to react quickly to an emergency, saving time and money in restoring normal business. A well thought out, coordinated response helps prevent personal injury, property damage, and lessen the resulting hazard. When an organization plans on how it will respond to an emergency threatening its operations, it is more likely to survive the incident. During a large-scale disaster, local response agencies may be overwhelmed and unable to immediately respond to the organization site. The modelling and analysis of threats in a plant is not just for post hazard analysis, it includes all the working procedures when a hazard occurs.
Earthquake Detection System using Wireless Sensor Network
Authors: Shaikh Farhan
Published: July 2021

Internet Technology bring methods to help detection of earthquake management to collect the data or monitor the condition in real time to analyse the collected data. The Internet of things (IOT) is the network of computed physical objects which enables these things to connect, collect and exchange data. The signal from each sensor which senses the waves and transmitter transfers the alert signal to the cloud. The cloud which will generates alert message transfers the warning to smart phones. Thus, early alert message is received by the people in terms of location, time and other parameters. This will in turn help the people from avoiding major damages to themselves and will help save their lives.
IOT Based Smart Parking System
Authors: Kumar H. Venkatesh
Published: July 2021

In This project we are designing an IoT based Smart parking system that integrates with mobile Application. It provides a comprehensive parking solution both for the user and owner of the parking space. Features are provided for reserving a parking space, authenticating a reserved user, identifying nearest free space depending on the size of the vehicle, navigating to the parking slot and computes accounts information on daily, weekly and monthly basis. IR sensors are used to identify if a parking spot is free. Availability of a free slot with its location information is transmitted using WIFI module technology, microcontroller and wireless communication technology to the server and is retrieved though a mobile application. RFID tag attached to a vehicle is used to authenticate a user who reserves the parking slot on an hourly, daily, weekly or monthly basis. A scheduling algorithm is used to identify the nearest free slot based on the size of a vehicle. The owner of the parking space can get the analytics of the number of free and available slots for a given period, the occupancy rate on week days and weekend and the amount collected for a given period and can use it for fixing variable parking fees. The mobile application is designed to provide rich customer experience.
Digital Bookstore
Authors: Thakur Amey
Published: July 2021

The project's main goal is to build an online book store where users can search for and buy books based on title, author, and subject. The chosen books are shown in a tabular style and the customer may buy them online using a credit card. Using this Website, the user may buy a book online rather than going to a bookshop and spending time. Many online bookstores, such as Powell's and Amazon, were created using HTML. We suggest creating a comparable website with .NET and SQL Server. An online book store is a web application that allows customers to purchase ebooks. Through a web browser the customers can search for a book by its title or author, later can add it to the shopping cart and finally purchase using a credit card transaction. The client may sign in using his login credentials, or new clients can simply open an account. Customers must submit their full name, contact details, and shipping address. The user may also provide a review of a book by rating it on a scale of one to five. The books are classified into different types depending on their subject matter, such as software, databases, English, and architecture. Customers can shop online at the Online Book Store Website using a web browser. A client may create an account, sign in, add things to his shopping basket, and buy the product using his credit card information. As opposed to a frequent user, the Administrator has more abilities. He has the ability to add, delete, and edit book details, book categories, and member information, as well as confirm a placed order. This application was created with PHP and web programming languages. The Online Book Store is built using the Master page, data sets, data grids, and user controls.