bluuebunny/crossref_metadata_2025 huggingface dataset:
Relationship between insecticide resistance profiles in Anopheles gambiae sensu lato and agricultural practices in Côte d’Ivoire
Authors: Kouadio France-Paraudie A. , Wipf Nadja C. , Nygble Angele S. , Fodjo Behi K. , Sadia Christabelle G. , Vontas John , Mavridis Konstantinos , Müller Pie , Mouhamadou Chouaïbou S.
Published: August 2023

Background

Insecticide-based malaria vector control is increasingly undermined due to the development of insecticide resistance in mosquitoes. Insecticide resistance may partially be related to the use of pesticides in agriculture, while the level and mechanisms of resistance might differ between agricultural practices. The current study aimed to assess whether phenotypic insecticide resistance and associated molecular resistance mechanisms in Anopheles gambiae sensu lato differ between agricultural practices.

Methods

We collected An. gambiae s.l. larvae in six sites with three different agricultural practices, including rice, vegetable and cocoa cultivation. We then exposed the emerging adult females to discriminating concentrations of bendiocarb (0.1%), deltamethrin (0.05%), DDT (4%) and malathion (5%) using the standard World Health Organization insecticide susceptibility test. To investigate underlying molecular mechanisms of resistance, we used multiplex TaqMan qPCR assays. We determined the frequency of target-site mutations, including Vgsc-L995F/S and Vgsc-N1570Y, and Ace1-G280S. In addition, we measured the expression levels of genes previously associated with insecticide resistance in An. gambiae s.l., including the cytochrome P450-dependent monooxygenases CYP4G16, CYP6M2, CYP6P1, CYP6P3, CYP6P4, CYP6Z1 and CYP9K1, and the glutathione S-transferase GSTe2.

Results

The An. gambiae s.l. populations from all six agricultural sites were resistant to bendiocarb, deltamethrin and DDT, while the populations from the two vegetable cultivation sites were additionally resistant to malathion. Most tested mosquitoes carried at least one mutant Vgsc-L995F allele that is associated with pyrethroid and DDT resistance. In the cocoa cultivation sites, we observed the highest 995F frequencies (80–87%), including a majority of homozygous mutants and several in co-occurrence with the Vgsc-N1570Y mutation. We detected the Ace1 mutation most frequently in vegetable-growing sites (51–60%), at a moderate frequency in rice (20–22%) and rarely in cocoa-growing sites (3–4%). In contrast, CYP6M2, CYP6P3, CYP6P4, CYP6Z1 and CYP9K1, previously associated with metabolic insecticide resistance, showed the highest expression levels in the populations from rice-growing sites compared to the susceptible Kisumu reference strain.

Conclusion

In our study, we observed intriguing associations between the type of agricultural practices and certain insecticide resistance profiles in the malaria vector An. gambiae s.l. which might arise from the use of pesticides deployed for protecting crops.

Graphical Abstract
Sex differences in metabolic phenotype and hypothalamic inflammation in the 3xTg-AD mouse model of Alzheimer’s disease
Authors: Robison Lisa S. , Gannon Olivia J. , Salinero Abigail E. , Abi-Ghanem Charly , Kelly Richard D. , Riccio David A. , Mansour Febronia M. , Zuloaga Kristen L.
Published: August 2023

Background

Alzheimer’s disease (AD) is notably associated with cognitive decline resulting from impaired function of hippocampal and cortical areas; however, several other domains and corresponding brain regions are affected. One such brain region is the hypothalamus, shown to atrophy and develop amyloid and tau pathology in AD patients. The hypothalamus controls several functions necessary for survival, including energy and glucose homeostasis. Changes in appetite and body weight are common in AD, often seen several years prior to the onset of cognitive symptoms. Therefore, altered metabolic processes may serve as a biomarker for AD, as well as a target for treatment, considering they are likely both a result of pathological changes and contributor to disease progression. Previously, we reported sexually dimorphic metabolic disturbances in ~ 7-month-old 3xTg-AD mice, accompanied by differences in systemic and hypothalamic inflammation.

Methods

In the current study, we investigated metabolic outcomes and hypothalamic inflammation in 3xTg-AD males and females at 3, 6, 9, and 12 months of age to determine when these sex differences emerge.

Results

In agreement with our previous study, AD males displayed less weight gain and adiposity, as well as reduced blood glucose levels following a glucose challenge, compared to females. These trends were apparent by 6–9 months of age, coinciding with increased expression of inflammatory markers (Iba1, GFAP, TNF-α, and IL-1β) in the hypothalamus of AD males.

Conclusions

These findings provide additional evidence for sex-dependent effects of AD pathology on energy and glucose homeostasis, which may be linked to hypothalamic inflammation.
Association of blood pressure trajectories with coronary heart disease among the disabled population in Shanghai, China: a cohort study of 7 years following up
Authors: Li Yao , Wu Jing , Wang Yiyan , Lei Hongmei , Jiang Chenghua , Zhai Hua , Wu Hengjing
Published: August 2023

Background

Much less is known about the importance of blood pressure (BP) trajectories concerning the incidence of coronary heart disease (CHD) in people with disabilities. Our aim was to evaluate this association.

Methods

This cohort study surveyed 5711 adults from the Shanghai Disability Health Survey from June 2012 to June 2019. The latent class growth mixture model was used to examine distinct BP trajectories. We evaluated the association of BP trajectories with the risk of CHD by Cox proportional hazard models. The model for CHD risk fitted to BP trajectories was compared with models fitted to other BP-related indicators by goodness-of-fit, discrimination, and calibration.

Results

During a median follow-up of 71.74 months, 686 cases (median age was 49.03 (54.49, 58.55) years, 51.90% female) with CHD were identified, with a cumulative incidence of 12.01%. Systolic BP (SBP) and diastolic BP (DBP) were categorized into three classes, respectively. A statistically significant association was only observed between SBP trajectories and CHD. Compared with the normotensive stable SBP group (n = 1956), the prehypertension-stable group (n = 3268) had a higher risk (adjust hazards ratio (aHR) = 1.266, 95% confidence interval (CI) 1.014–1.581), and the stage 1 hypertension-decreasing group (n = 487) had the highest risk (aHR = 1.609, 95%CI 1.157–2.238). Among the BP-related indicators, the SBP trajectory was the strongest predictor of new-onset CHD. Findings were similar when sensitivity analyses were conducted.

Conclusions

SBP trajectory was a more important risk factor for CHD than other BP-related indicators and stringent BP control strategies may be effective for primary CHD prevention in the disabled population.
From the “Green Station” to the “Blue Station”: the role of the renovation of railway stations in the ecological transition of cities. Calculation model and possible measures for mitigation and compensation of impacts.
Authors: Spinosa Andrea
Published: August 2023

Nowadays, mobility represents the main productive process: this means that territorial sustainability must necessarily include sustainable movements as a key component. The increase in transport entity and transport routes, economic convenience, and, last but not least, a higher environmental awareness, are leading to higher consideration of the use of railways. In this framework, railway stations represent complex objects requiring significant material flows, which make up their ecological footprint. In this sense, a railway station is the last industrial plant to be accepted in contemporary cities. The last 2 years of pandemics have amplified both the need for tangible sustainability and the demand for active mobility-friendly cities. Discussing the sustainability of a station involves examining and measuring its ecological footprint, to provide active support to the targeted planning and design of mitigation measures. Their impact and effectiveness are certainly amplified by the natural central role of the railway stations. And what if the pursuit of sustainability for the railway stations could be intertwined with the search for quality collective spaces? The answer is positive. The proposed algorithm allows shifting from a qualitative view (so to say, measured on a flat-rate basis), to a quantitative view of the possible improvement actions on the operation and maintenance processes of railway stations. Moreover, through minor adaptations, it could also be applied to industrial or residential processes.
Effect of central PxxP motif in amphipathic alpha-helical peptides on antimicrobial activity and mode of action
Authors: Lee Hyunhee , Yang Sungtae , Shin Sung-Heui
Published: August 2023

Amphipathic α-helical peptides (AHPs) have shown potential as a therapeutic approach against multi-drug-resistant bacterial infections due to their broad-spectrum antimicrobial activity by disrupting bacterial membranes. However, their nonspecific interactions with membranes often result in cytotoxicity toward mammalian cells. Previous studies have shown that a PxxP motif near the middle of cathelicidin-derived antimicrobial peptides contributes to potent and selective antibacterial activity. In this study, we compared KL18 with KL-PxxP to examine the effects of the central PxxP motif in AHPs on their structure, antibiotic activity, and mode of action. In a membrane-mimetic environment, we observed that KL18 had a much higher helical content compared to KL-PxxP. In aqueous buffer, KL18 adopted a highly ordered α-helical conformation, while KL-PxxP exhibited a disordered conformation. We found that KL-PxxP exhibited 4–16 times higher antibacterial activity than KL18 and significantly reduced the hemolytic activity. These findings suggest that the dynamic conformational behaviors caused by the central PxxP motif conferred the antibacterial selectivity of AHPs. Additionally, KL-PxxP showed strong binding to anionic liposomes and weak binding to zwitterionic liposomes, explaining its selectivity for bacteria over mammalian cells. Despite having a low ability to dissipate the bacterial membrane potential, KL-PxxP translocated efficiently across lipid membranes. Therefore, we propose that the central PxxP motif in AHPs provides dynamic conformational behavior in aqueous and membrane-mimetic environments, enhances binding to anionic membranes, and facilitates translocation across lipid bilayers, resulting in improved antibacterial potency and selectivity. Understanding the unique structural characteristics and functional roles of the PxxP motif in the antimicrobial mechanism of action holds great potential for advancing the development of novel peptide antibiotics.
On new two-dimensional UHF radar observations of equatorial spread F at the Jicamarca Radio Observatory
Authors: Rodrigues F. S. , Milla M. A. , Scipion D. , Apaza J. M. , Kuyeng K. M. , Sousasantos J. , Massoud A. A. , Padin C.
Published: August 2023

We describe a mode for two-dimensional UHF (445 MHz) radar observations of F-region irregularities using the 14-panel version of the advanced modular incoherent scatter radar (AMISR-14). We also present and discuss examples of observations made by this mode. AMISR-14 is installed at the Jicamarca Radio Observatory (JRO, 11.95°S, 76.87°W, ~ 0.5° dip latitude) in Peru and, therefore, allows studies of ionospheric irregularities at the magnetic equator. The new mode takes advantage of the electronic beam-steering capability of the system to scan the equatorial F-region in the east–west direction. Therefore, it produces two-dimensional views of the spatial distribution of sub-meter field-aligned density irregularities in the magnetic equatorial plane. The scans have a temporal resolution of 20 s and allow observations over a zonal distance of approximately 400 km at main F-region heights. While the system has a lower angular and range resolution than interferometric in-beam VHF radar imaging observations available at Jicamarca, it allows a wider field-of-view than that allowed with the VHF system. Here, we describe the mode, and present and discuss examples of observations made with the system. We also discuss implications of these observations for studies of ESF at the JRO.

Graphical abstract
A new three‐dimensional patient‐specific cutting guide for opening wedge high tibial osteotomy based on ct scan: preliminary in vitro results
Authors: Rosso Federica , Rossi Roberto , Neyret Philippe , Śmigielski Robert , Menetrey Jacques , Bonasia Davide Edoardo , Fucentese Sandro Franco
Published: August 2023

Purpose

The aim of this study was to evaluate the accuracy of a patient‐specific cutting guide on both coronal and sagittal alignment compared to the pre‐operative planning in OWHTO.

Methods

Twelve OWHTO on 6 cadaveric specimens were performed by 3 experienced knee surgeons using patient‐specific cutting guides based on 3D pre‐operative planning. Since the specimens had no major deformities, a fixed correction of 6° on the left and 10° on the right legs were carried out to simulate different scenarios. A pre‐operative and post‐OWHTO 3D CT scans were performed, and images were superimposed using the dedicated 3D planning software to align their reference axes. A pre‐operative planning was performed considering both Medial Proximal Tibial Angle (MPTA) and Posterior Tibial Slope (PTS), and a patient‐specific cutting guide was produced. Planned and post‐OWHTO MPTA and PTS were evaluated (mean and standard deviation), and Pearson’s correlation coefficient was calculated to assess precision and accuracy of the whole treatment.

Results

A mean correction of 6,1° (SD 1,9°) and 1,2° (SD 1°) was obtained respectively in the coronal plane (MPTA) and in the sagittal plane (PTS). The average difference between planned and post‐OWHTO MPTA and PTS was respectively 1,2° (SD 0,6°) and 1,2° (SD 1°) in the sagittal plane (PTS). Pearson’s correlation coefficient demonstrated a good accuracy of the treatment in both coronal and sagittal plane (respectively r=0,95 and r=0,86). No lateral hinge fractures were detected at the post‐operative CT scan.

Conclusion

OWTHO performed with the help of 3D patient specific cutting guide on cadaveric specimens demonstrated good accuracy and reliability in obtaining the planned correction. In vivo studies are necessary to confirm these results and evaluate cost‐effectiveness of this system.

Level of evidence

Level IV cadaveric study.
The effect of leukocyte- and platelet-rich fibrin on the bone loss and primary stability of implants placed in posterior maxilla: a randomized clinical trial
Authors: Naeimi Darestani Meshkat , Asl Roosta Hoori , Mosaddad Seyed Ali , Yaghoubee Siamak
Published: August 2023

Purpose

In this study, we investigated the effects of leukocyte- and platelet-rich fibrin (L-PRF) on implant stability and alterations in the marginal bone surrounding posterior maxillary implants.

Methods

This randomized clinical trial was conducted to compare the variable of L-PRF placement around maxillary implants. Resonance frequency analysis (RFA) was used to evaluate the implant stability immediately after surgery and at 1, 2, 4, 6, 8, and 12 weeks after surgery (t0 to t6, respectively). In addition, the amount of marginal bone changes around the implant at t6 was compared with the baseline using periapical radiography.

Results

The RFA outcomes were statistically significant within each group (P < 0.001, Eta2 = 0.322); however, in none of the follow-ups and immediately after the surgery, there was a significant difference between the two groups in terms of the implant stability quotient (ISQ) scores (P > 0.05). At t0, the test and control groups' respective mean levels of marginal bone loss around the implants were 0.4836 mm and 0.7343 mm, significantly different from the corresponding values at t6. On the other hand, marginal bone loss around the implant was not significantly different between the two groups in t0 and t6 (P = 0.532).

Conclusions

L-PRF did not improve the RFA outcomes of implants three months after implant placement, and changes in the ISQ values over time were the same in both groups. In addition, L-PRF had no superior effect on the marginal bone loss around the implants.

Trial registration number: The research was registered in the Iranian Registry of Clinical Trials on 22 December 2020 (No: IRCT20200624047906N1), available at http://www.irct.ir
Robotically assisted total gastrectomy for lymphadenopathy after long-term follow-up for multiple type 1 gastric neuroendocrine tumor (NET): a case report
Authors: Funatsu Nozomi , Hara Kentaro , Takagi Maki , Onodera Atsushi , Ueno Kohdai , Endo Kazuya , Cho Haruhiko
Published: August 2023

Background

Type 1 gastric neuroendrine tumor (NET) is usually associated with chronic atrophic gastritis and forms multiple lesions. While most cases of type 1 gastric NET are generally slowly growing, some develop regional lymph node metastases even after long-term dormancy.

Case presentation

A 73-year-old male patient with a 32-year history of multiple gastric NET was being followed-up at the study center after endoscopic submucosal dissection (ESD) of a large gastric NET. A blood examination revealed high serum gastrin (> 3000 pg/ml). An endoscopic examination found atrophic mucosa and multiple, elevated lesions in the upper to lower stomach body. Computed tomography (CT) revealed regional lymphadenopathy in the greater omentum along the gastroepiploic artery. Robotically assisted total gastrectomy was performed with D2 lymphadenectomy and Roux-en-Y reconstruction. Pathological analysis revealed a large number of gastric NET (grade 1) with a maximum size of 4.5 mm invading the submucosal layer. A single lymph node metastasis was also detected pathologically at station #4d. The postoperative course was uneventful, and serum gastrin normalized postoperatively. At postoperative year 3, the patient has been doing well without any recurrences.

Conclusions

The present case of multiple gastric NET with a single regional lymph node metastasis at year 32 of follow-up was successfully treated with a robotically assisted total gastrectomy.
Time-restricted eating (16/8) and energy-restricted diet: effects on diet quality, body composition and biochemical parameters in healthy overweight females
Authors: Mengi Çelik Özge , Köksal Eda , Aktürk Müjde
Published: August 2023

Background

Time-restricted eating (TRE) is a current popular dietary strategy for noncommunicable diseases. However, studies demonstrated contradictory results for it and in all dietary strategies, diet quality is an the important part of the well-being. Our study aimed to investigate the effect of TRE and energy-restricted diet (ERD) on the nutritional status and diet quality of individuals.

Methods

This pilot study was completed 23 healthy overweight female. Anthropometric and body composition measurements of individuals were taken. The energy expenditure was measured using indirect calorimetry. Blood pressure and heart rate measurements were made. Biochemical parameters were evaluated and food consumption were taken. The quality of dietary intake was assessed using the Healthy Eating Index (HEI) -2015. The physical activity levels of the individuals were estimated using the physical activity record. The Statistical Package for the Social Sciences (version 22.0) software was used for all analyses. A p-value of less than 0.05 was considered to be statistically significant.

Results

After 8 weeks of intervention, while no change was observed in the diet quality of the individuals in the TRE group (p > 0.05), a significant increase was found in the diet quality score of the individuals in the ERD group (p < 0.05). There was a 3.2% and 5.5% decrease in body weight of individuals in the TRE and ERD groups, respectively (p < 0.05). While no significant change was observed in the body fat percentage of individuals in the TRE group (p > 0.05), a 7.1% decrease was observed in the ERD group (p < 0.05). A statistically significant decrease was found in the total cholesterol (3.7%) in the ERD group, and in the total cholesterol (6.7%) and low density lipoprotein cholesterol (LDL-C) (6.5%) in the TRE group. In addition, a statistically significant increase was found in adiponectin (77.3%) and total antioxidant status (TAS) (13.2%) in the ERD group.

Conclusion

Energy-restricted diet yielded better results in weight loss and improvement of body composition and diet quality compared to TRE. Also, a decrease in total cholesterol level was found in the ERD group. However, more studies should be done with longer follow-ups and high sample sizes are very important in terms of creating public health-based recommendations.
Effectiveness of Exercise Treatments with or without Adjuncts for Common Lower Limb Tendinopathies: A Living Systematic Review and Network Meta-analysis
Authors: Challoumas Dimitris , Crosbie Gearoid , O’Neill Seth , Pedret Carles , Millar Neal L.
Published: August 2023

Introduction

Exercise therapy is usually prescribed as first-line treatment for lower limb tendinopathies. The multitude of exercise- and non-exercise-based management options can be overwhelming for the treating sports professional and patient alike. We chose to investigate the comparative effectiveness of exercise therapy with or without adjuncts for managing the commonest lower limb tendinopathies.

Methods

Through an extensive systematic literature search using multiple databases, we aimed to identify eligible randomised controlled trials (RCTs) on Achilles tendinopathy, patellar tendinopathy or greater trochanteric pain syndrome (GTPS) that included at least one exercise intervention in their treatment arms. Our primary outcomes were patient-reported pain and function (Victorian Institute of Sport Assessment; VISA). Follow-up was defined as short-term (≤ 12 weeks), mid-term (> 12 weeks to < 12 months) and long-term (≥ 12 months). The risk of bias and strength of evidence were assessed with the Cochrane Collaboration and GRADE-NMA tools, respectively. Analyses were performed separately for each one of the three tendinopathies.

Results

A total of 68 RCTs were included in the systematic review. All pairwise comparisons that demonstrated statistically and clinically significant differences between interventions were based on low or very low strength of evidence. Based on evidence of moderate strength, the addition of extracorporeal shockwave therapy to eccentric exercise in patellar tendinopathy was associated with no short-term benefit in pain or VISA-P. From the network meta-analyses, promising interventions such as slow resistance exercise and therapies administered alongside eccentric exercise, such as topical glyceryl trinitrate for patellar tendinopathy and high-volume injection with corticosteroid for Achilles tendinopathy were based on low/very low strength of evidence.

Conclusion

In this network meta-analysis, we found no convincing evidence that any adjuncts administered on their own or alongside exercise are more effective than exercise alone. Therefore, we recommend that exercise monotherapy continues to be offered as first-line treatment for patients with Achilles and patellar tendinopathies and GTPS for at least 3 months before an adjunct is considered. We provide treatment recommendations for each tendinopathy.

PROSPERO registration number CRD42021289534.
Baseline demographic, clinical and multimodal imaging features of young patients with type 2 macular telangiectasia
Authors: Reddy Nikitha Gurram , Prabhu Vishma , Sharma Sumanth Vinayak , Acharya Isha , Mangla Rubble , Yadav Naresh Kumar , Chhablani Jay , Narayanan Raja , Venkatesh Ramesh
Published: August 2023

Purpose

Macular telangiectasia (MacTel) type 2 is observed in patients in their 5th–8th decades of life. The clinical and imaging findings in younger patients is unknown in larger cohorts. The study purpose is to report prevalence, baseline clinical and spectral domain optical coherence tomography (SDOCT) findings in young MacTel patients below 40 years.

Methods

This hospital-based, multicentre, retrospective, cross-sectional study included patients between 2011 and 2023. Retinal photographs from multiple imaging techniques were evaluated to diagnose and stage type 2 MacTel and describe their SDOCT findings. Imaging characteristics were correlated with clinical stages and visual acuity.

Results

Among all MacTel patients seen in hospital, prevalence of young MacTel cases less than age 40 was 1.77% (32/1806; 62 eyes). Youngest participant was 34 years, while mean age was 38.44 ± 1.795 years. Sixteen patients (50%) were diabetics. Perifoveal greying (n = 56, 90%) and perifoveal hyperreflective middle retinal layers (n = 47, 76%) were the most prevalent clinical and SDOCT imaging finding respectively. Less than 10% (n = 6) eyes had proliferative disease. Presence of retinal pigment clumps (RPC) (7% vs. 67%; p = 0.002) coincided with proliferative MacTel. Poor vision was associated with presence of outer retinal layer SDOCT findings like outward bending of inner retinal layers (p = 0.047), RPC (p = 0.007), subfoveal neurosensory detachment (p = 0.048) and subretinal neovascular membrane (p = 0.001).

Conclusion

Type 2 MacTel before age 40 is rare, common in women and diabetics, and affects vision in advanced stage. Disease symmetry, comparison with older cases, and longitudinal SDOCT changes in such patients require further study.
Anti-obesity effects of yuja (Citrus junos Sieb ex Tanaka) pomace extract fermented with lactic acid bacteria on the hepatocytes and epididymal fat tissue of rats
Authors: Chu Han-Na , Kim Haeng-Ran , Jang Kyeong-A. , Hwang Yu-Jin , Kim Jeong-Sang
Published: August 2023

This study investigated the anti-obesity effects of yuja pomace extract fermented with lactic acid bacteria in rats with high-fat diet-induced obesity over a period of eight weeks. Epididymal fat cell size was significantly smaller, by about 33%, in the treatment groups given yuja pomace extract fermented with lactic acid bacteria compared to the CON group. Electron microscopic observation of hepatocyte microstructure showed that the number of lipid droplets was lower in hepatocytes, the number of mitochondria was higher, along with distinct cristae, and the rough endoplasmic reticula were well developed with stacks of cisternae and ribosomes. Thus, it is believed that yuja pomace extract fermented with lactic acid bacteria, by influencing body weight and lipid accumulation, is effective in the prevention and treatment of obesity.
A discursive review of the effectiveness and utility of exercise therapy in the subacute stage of recovery from critical illness
Authors: Marcinski Waldemar , Kuisma Raija
Published: August 2023

Background

The coronavirus pandemic precipitated an increase in admissions to intensive care units (ICU). The related medium to long-term sequelae of critical illness posed a significant challenge to function and quality of life after discharge from the acute hospital, often requiring continued therapeutic input. Current evidence suggests that exercise therapy is effective in rehabilitating multiple systemic conditions. However, its role in post-ICU recovery remains unclear.

The objective of this article was to discuss the merits and demerits of the exercise in subacute post-ICU settings based on available evidence. Effective, evidence-based rehabilitation from critical illness is crucial due to the increased number of patients and the significant burden on care and participation of those individuals.

Methods

The materials for this discursive review were selected after several database searches and analysis of available articles. As a result, six papers were found, four of which provided evidence for the beneficial effect of exercise in subacute rehabilitation of post-ICU patients, and two reported no differences between interventions and control groups.

Results

Most of the studies found cardiovascular exercise to be safe and somewhat beneficial. However, adherence and attrition were problematic in this patient group, and the studies suffered methodological and measurement problems regarding group selection, exercise prescription and outcome measures applied.

Conclusion

The existing evidence base did not allow an informed consensus regarding the value of exercise in the subacute post-ICU recovery or lack thereof. Therefore, further investigation into patient retention strategies, exercise prescription and the choice of appropriate outcome measures is necessary.
Whole Blood–based Transcriptional Risk Score for Nonobese Type 2 Diabetes Predicts Dynamic Changes in Glucose Metabolism
Authors: Hou Yanan , Dai Huajie , Chen Na , Zhao Zhiyun , Wang Qi , Hou Tianzhichao , Zheng Jie , Wang Tiange , Li Mian , Lin Hong , Wang Shuangyuan , Zheng Ruizhi , Lu Jieli , Xu Yu , Chen Yuhong , Liu Ruixin , Ning Guang , Wang Weiqing , Bi Yufang , Wang Jiqiu , Xu Min
Published: August 2023

Context

The performance of peripheral blood transcriptional markers in evaluating risk of type 2 diabetes (T2D) with normal body mass index (BMI) is unknown.

Objective

We developed a whole blood–based transcriptional risk score (wb-TRS) for nonobese T2D and assessed its contributions on disease risk and dynamic changes in glucose metabolism.

Methods

Using a community-based cohort with blood transcriptome data, we developed the wb-TRS in 1105 participants aged ≥40 years who maintained a normal BMI for up to 10 years, and we validated the wb-TRS in an external dataset. Potential biological significance was explored.

Results

The wb-TRS included 144 gene transcripts. Compared to the lowest tertile, wb-TRS in tertile 3 was associated with 8.91-fold (95% CI, 3.53-22.5) higher risk and each 1-unit increment was associated with 2.63-fold (95% CI, 1.87-3.68) higher risk of nonobese T2D. Furthermore, baseline wb-TRS significantly associated with dynamic changes in average, daytime, nighttime, and 24-hour glucose, HbA1c values, and area under the curve of glucose measured by continuous glucose monitoring over 6 months of intervention. The wb-TRS improved the prediction performance for nonobese T2D, combined with fasting glucose, triglycerides, and demographic and anthropometric parameters. Multi-contrast gene set enrichment (Mitch) analysis implicated oxidative phosphorylation, mTORC1 signaling, and cholesterol metabolism involved in nonobese T2D pathogenesis.

Conclusion

A whole blood–based nonobese T2D-associated transcriptional risk score was validated to predict dynamic changes in glucose metabolism. These findings suggested several biological pathways involved in the pathogenesis of nonobese T2D.
Laparoscopic Anatomical Liver Resection of Segment VIII by Using ICG Fluorescence Positive Staining Under the Guidance of Laparoscopic Ultrasonography
Authors: Sun Ji , Lu Zhi-Yu , Zhai Jian-Xin , Lang Meng-Ran , Wang Hong-Guang
Published: August 2023

Background

Anatomical segmentectomy is a surgical procedure that completely removes a territory (or territories) of the third-order portal venous branches of a Couinaud segment (Wakabayashi et al. in J Hepatobil Pancreat Sci 29(1):82–98, 2022. https://doi.org/10.1002/jhbp.899). Laparoscopic segmentectomy of S8 is considered technically challenging because of the Precise dissection of the Glissonean pedicle of S8, and exposure of the middle and right hepatic veins are required (Ome et al. in J Am Coll Surg 230(3):e13–e20, 2020; Wakabayashi et al. in Ann Surg 261(4):619–29, 2015. https://doi.org/10.1097/sla.0000000000001184; Monden et al. in J Hepatobil Pancreat Sci 29(1):66–81, 2022. https://doi.org/10.1002/jhbp.898). This report describes a new approach, which can reduce unwanted damage to normal tissues and complications.

Methods

A 53-year-old man who has suffered from hepatitis B for 10 years was admitted for the treatment of two nodular tumors located in segment VIII. The surgical procedure began with the percutaneous injection of 5 mL, 0.025 mg/mL of ICG into the S8 portal branch by using an 18G PTCD needle under the guidance of laparoscopic ultrasound (Xu et al. in Surg Endosc 34(10):4683–4691, 2020. https://doi.org/10.1007/s00464-020-07691-5; Wang et al. in Ann Surg 274(1):97–106, 2021. https://doi.org/10.1097/sla.0000000000004718; Aoki et al. in J Am Coll Surg 230(3):e7–e12, 2020. https://doi.org/10.1016/j.jamcollsurg.2019.11.004), followed by liver transection on the cranial side of the liver, which used the ICG fluorescence images for exposing the roots of the middle and right hepatic veins and dissecting and ligating S8 portal pedicle. The excision specimen was sent for histopathological diagnosis.

Results

It took 200 min for the operation and 60 min for the total Pringle maneuver. The estimate of blood loss was 110 mL. The final histopathologic results of the two nodules were hepatocellular carcinoma (HCC). The patient was discharged on postoperative Day 6 with no complications.

Conclusions

Laparoscopic anatomical liver resection of S8 has been demonstrated to be feasible. Under the guidance of laparoscopic ultrasonography, ICG positive staining was proven to be optimal for Anatomical segmentectomy.
Effective Mn Doping of Co3O4 to Improve the Catalytic Performance of Co3O4/N-doped Carbon toward Hydrogenation Reduction Reaction of p-Nitrophenol
Authors: Fu Xiaojian , Huang Boxing , Li Kuilin , Shen Yanchao , Li Pingyun
Published: August 2023

This work reports that 5% Mn doping of Co3O4 can greatly improve catalytic performance of Co3O4/N-doped carbon (Co3O4/NC) catalysts toward hydrogenation reaction of p-nitrophenol by using NaBH4 as reducing agent. Mn doping can cause formation of cobalt or oxygen vacancies without changing the crystalline structure of Co3O4. The 5%Mn-doped Co3O4/NC has a high activity parameter of 173 s−1·g−1 when the molar ratio of NaBH4:p-nitrophenol is 100:1, while the un-doped Co3O4/NC catalyst has a low parameter of 37.0 s−1·g−1.
PROJECT ACTIVITY OF THE CULTURAL INDUSTRY: NEW SOCIOLOGICAL APPROACHES
Authors: Malshina Natalia A. , Kamenskaya Irina V.
Published: August 2023

The project activity of the cultural industry can be considered as an integrative indicator of the entire social system, capable of controlling individual subsystems, such as financial, behavioral and semantic ones. The cultural system, which serves as an intermediary in the structure of the social system, is easily transferred from one subsystem to another, and with the help of training and socialization – from one personality system to another. The symbolic nature of culture gives it the ability to control other systems of action. The application of the modeling method within the framework of the sociological approach to the Russian cultural industry allows us to form a general model of the cultural industry. The use of tools of sociological analysis of the audience to understand its needs and cultural values helps to build correlations with both the production of a cultural product and its implementation. At the same time, the survey of the target audience should not be of an evaluative nature, but should proceed from the analysis of problems of concern to consumers of culture, as well as assistance in solving them by modern cultural institutions. The study of the target audience by means of sociological analysis will modernize the activities of cultural organizations, make it more effective, help both in the preparation of individual projects and in the process of ongoing activities.
The impact of the SARS-CoV-2 infection on the risk of developing preeclampsia
Authors: Kozłowska Anna , Korzeniowska Anna , Gendek Karolina , Gąbka Ilona , Dalmata Weronika , Dąbrowski Jan , Zygmunt-Siembida Ewelina , Chojęta Dariusz
Published: August 2023

Introduction and purpose: 
 
The COVID-19 pandemic has significantly affected the health, life and quality of life of many people around the world. It caused huge changes in the daily functioning of entire societies. Pregnant women are a unique group of people who are particularly at risk. They are accompanied by fear for their health, but also fear of the impact of the disease on their offspring. The pandemic has also caused new challenges for mothers-to-be that have not occurred so far. In this paper, we would like to present the current state of knowledge on the impact of SARS-CoV-2 infection on the risk of developing pre-eclampsia.
 
State of knowledge:
 
We analyzed studies showing the impact of COVID-19 infection on the health of pregnant women, especially on the risk of developing pre-eclampsia. Data from many studies are contradictory. Some studies do not indicate a significant impact of coronavirus infection on the development of pre-eclampsia. Some of them confirm a higher incidence of pre-eclampsia in pregnant women with confirmed COVID-19 infection.
 
Conclusions:
 
Despite the experience gained, there are still many unknowns. Thanks to research, we have more and more knowledge about the course of COVID-19 in pregnant women and its impact on their lives. Many observations are still needed to formulate clear conclusions about the impact of COVID-19 on the risk of developing pre-eclampsia. It is also necessary to continue to educate women, encourage compliance with the recommendations of doctors and the World Health Organization to prevent the spread of coronavirus.
Atrial fibrillation after coronary bypass graft - what do we know now?
Authors: Misiło Adriana , Sosna Monika , Mordoń Krzysztof
Published: August 2023

Introduction: Atrial fibrillation (AF) is the most common supraventricular arrhythmia in clinical practice. The percentage of people with AF increases with age. The currently implemented procedure for detecting modifiable risk factors allows for early implementation of a therapeutic plan in primary and secondary prevention. The following work deals with the occurrence of atrial fibrillation, risk factors and ways of coping with the disease in patients undergoing coronary artery bypass grafting (CABG).
Materials and methods: The literature available on PubMed and Google Scholar was reviewed using the words „atrial fibrillation”, „coronary artery bypass grafting”.
Summary: Patients undergoing coronary artery bypass surgery are at risk of developing postoperative atrial fibrillation. This is especially true for older patients with additional burdens, such as past arrhythmia episodes, hypertension, critical stenosis of the right coronary artery.
A Bisection Protocol for Political Redistricting
Authors: Ludden Ian G. , Swamy Rahul , King Douglas M. , Jacobson Sheldon H.
Published: August 2023

The authors conceived of the bisection protocol during a research meeting discussing recent political redistricting literature, in particular, the I-cut-you-freeze protocol preprint. After establishing the theoretical results for the continuous nongeometric setting, they discussed ways to implement both protocols on real-world data, culminating in the Iowa case study and computational experiments with 17 other states.
Online Stochastic Max-Weight Bipartite Matching: Beyond Prophet Inequalities
Authors: Papadimitriou Christos , Pollner Tristan , Saberi Amin , Wajc David
Published: August 2023

The rich literature on online Bayesian selection problems has long focused on so-called prophet inequalities, which compare the gain of an online algorithm to that of a “prophet” who knows the future. An equally natural, though significantly less well-studied, benchmark is the optimum online algorithm, which may be omnipotent (i.e., computationally unbounded), but not omniscient. What is the computational complexity of the optimum online? How well can a polynomial-time algorithm approximate it? Motivated by applications in ride hailing, we study the above questions for the online stochastic maximum-weight matching problem under vertex arrivals. For this problem, a number of [Formula: see text]-competitive algorithms are known. This is the best possible ratio for this problem, as it generalizes the original single-item prophet inequality problem. We present a polynomial-time algorithm, which approximates the optimal online algorithm within a factor of 0.51—strictly more than the best-possible constant against a prophet. In contrast, we show that it is PSPACE-hard to approximate this problem within some universal constant [Formula: see text].

Funding: Financial support from the National Science Foundation [Grants CCF1763970, CCF1812919, and CCF191070], the Office of Naval Research [Grant N000141912550], and Cisco Research is gratefully acknowledged.
ESPAÇO FICCIONAL E O INSÓLITO: A CONSTRUÇÃO DO HORROR NA CARTOGRAFIA SIMBÓLICA DA OBRA NOSSA PARTE DE NOITE (2019) DE MARIANA ENRIQUEZ
Authors: Suleiman das Dores Giovanna , Correia Fernanda Da Cunha
Published: August 2023

Este trabalho visa refletir a respeito da construção espacial e os recursos narrativos utilizados para a ambientação presente no romance Nossa Parte de Noite (2019) da autora argentina Mariana Enriquez. A discussão foi desenvolvida com o intuito de discorrer a respeito da organização do espaço ficcional em função da construção do horror nos capítulos "A coisa má das casas sozinhas, Buenos Aires, 1985-1986" e "Círculos de giz, 1960-1976" do romance, os quais apresentam duas casas distintas que compõem a cartografia simbólica da obra e a ambientação do horror a partir da caracterização e funcionamento dos dois espaços. Analisaremos o espaço ficcional sob o ponto de vista da pesquisadora Claudia Barbieri (2019), que apresenta o espaço ficcional como um agente ativo da obra, em constante diálogo com as personagens e que compõe o que a autora chama de "cartografia simbólica". Trataremos também do espaço ficcional sob o ponto de vista do pesquisador Gaston Bachelard (2014) na instância da categoria da forma do espaço ficcional retratado na obra. O horror será tratado sob o ponto de vista do teórico Noel Carroll (2004) que propõe como o horror é modalizado dentro das obras. Em face desse contexto, indagamos: Como que o espaço ficcional funciona para conceber os elementos insólitos e ambientar a narrativa dentro do horror? Quais são os recursos linguísticos e imagéticos utilizados em ambos os capítulos?
MULHERES À ESPERA: AS RUÍNAS DO TEMPO NOS CONTOS “LA CULPA ES DE LOS TLAXCALTECAS” E “¿QUÉ HORA ES...?” DE ELENA GARRO
Authors: Martins Natália Pereira , Oliveira Luiz Manoel Da Silva
Published: August 2023

Esse artigo busca compreender as rupturas no tempo cronológico em dois contos da escritora mexicana Elena Garro, ambos retirados do livro La semana de colores (1964): “La culpa es de los Tlaxcaltecas” e “¿Qué hora es…?”, respectivamente o primeiro e o terceiro contos do livro. Essa ruptura do tempo cronológica é sentida somente pelas protagonistas Laura e Lucía Mitre, as quais vivem em um tempo fragmentado e que recusa obedecer ao relógio e ao calendário. São incompreendidas e julgadas pelos outros personagens, para os quais o tempo corre em um ritmo distinto. Para tanto, faz-se necessário estudar a construção do maravilhoso nas narrativas da autora, bem como as teorias sobre as vertentes ficcionais do insólito na literatura hispano-americana do século XX.
DIFICULDADES E POSSIBILIDADES DA EDUCAÇÃO CRÍTICA EM TEMPOS DE FAKE NEWS: UMA REVISÃO SISTEMÁTICA
Authors: Silva Osni Oliveira Noberto da , Ramos Michael Daian Pacheco , Junior Paulo Antônio dos Santos , Santos Klaus Araújo
Published: August 2023

O presente artigo tem como tema a discussão sobre Fake News e ensino crítico. Apontamos como objetivo do artigo analisar a produção acadêmica contemporânea sobre educação crítica em tempos de Fake News. Nesse sentido, iremos: a) Mapear a produção acadêmica em periódicos qualificados da CAPES acerca da educação crítica relacionada ao enfrentamento da Fake News; 2) Refletir sobre o processo educativo em tempos de Fake News e; 3) Levantar possibilidades para os docentes atuarem em sua prática pedagógica, utilizando as tecnologias digitais no enfrentamento das Fake News. Nos apropriamos do referencial teórico que possibilitou analisar e compreender os impactos das Fake News e o papel da escola a partir dos estudos de Silva (2021), Cardoso (2021), Filho (2018) e Brasil (2018). Optamos por uma metodologia do tipo revisão sistemática e a coleta de dados ocorreu através de levantamento de artigos indexados no Google Scholar, tendo como critérios de inclusão textos acadêmicos publicados entre 2017 a 2021, apenas em língua portuguesa, utilizando como palavra chave “Fake News” e “Ensino crítico”. Identificamos 76 produções acadêmicas, sendo que após os critérios de inclusão e exclusão restaram um total de 9 artigos. Nossos principais resultados apontam: os artigos analisados situam-se entre os anos de 2017 a 2021 e expressam uma heterogeneidade; a discussão sobre as Fake News na sociedade e o impacto no ambiente escolar é um dos principais problemas da era tecnológica e da informação, levando-nos a adoção de abordagens que problematizem o uso das tecnologias e das mídias dentro do processo educativo.
VI SEMANA DE ARTE E CULTURA DO IFSC ARARANGUÁ: ARTE E CULTURA EM TEMPOS DE PANDEMIA
Authors: Salbego Nayara Nunes , Boenavides William Moreno , Nascimento Emerson Cardoso , Fernandes Fabiana Santos , Gründler Karla Goularte da Silva
Published: August 2023

Este relato de experiência trata sobre o evento de extensão Semana de Arte e Cultura (SAC) do IFSC Araranguá - SC, demonstrando, também, o projeto de extensão de mesmo nome. O objetivo do evento é promover experiência artístico-cultural, envolvendo estudantes, servidores e comunidade externa, através do incentivo a novas possibilidades educacionais por meio da cibercultura. O relato trata não apenas de ações didáticas apresentadas durante o desenvolvimento do projeto de extensão, mas também aborda atividades de preparação que culminam no momento principal do projeto de extensão, ou seja, o evento de extensão VI Semana de Arte e Cultura (SAC) do IFSC Araranguá.
FAKES NEWS NAS AULAS DE LÍNGUA PORTUGUESA NO PIBID LETRAS: LEITURA E AÇÕES (AUTO)FORMATIVAS
Authors: Silva Ana Lucia Gomes da , Neta Mirena Umbuzeiro Guimarães
Published: August 2023

Este texto é resultado da experiência gestada colaborativamente no Pibid Letras na Universidade do Estado da Bahia nas aulas de Língua Portuguesa com ênfase nas ações (auto)formativas da leitura a fim de contribuir para uma formação leitora crítica que toma como centralidade temas atuais do cotidiano dos/das estudantes de educação básica, a inserção de atividades e ações (auto)formativas. O objetivo central é apresentar a experiência realizada no combate às fake news, numa ação de co-docência implicada, cuja rede colaborativa, toma a experiência e a leitura como formação. De natureza qualitativa o estudo assume a pesquisa bibliográfica e documental como procedimentos metodológicos e como dispositivo de produção de dados e analítico a inspiração cartográfica. Adotou-se, como corpus de análise o conjunto de produções imagéticas, da experiência do Pibid Letras. Os resultados apontam evidências de aprendizagens, e pistas de coautoria e cocriação, propiciadas aos estudantes e docentes, em virtude da ambiência favorável e desafiadora, tais como: imersão em ambiências híbridas, aprendizagens diferenciadas em que fomos instados a exercitar e experimentar juntos na educação on line diante da concepção de aula em co docência. Apontaram ainda os (re)planejamentos e inflexões realizadas no processo, sobretudo para suscitar a leitura crítica das fake news, considerando a escuta sensível dos distintos pontos de vista dos sujeitos envolvidos, o debate democrático, atentando para os princípios epistemológicos e organizativos da metodologia de trabalho adotada no Pibid, produzindo nas aulas a (auto) formação fronteiriça universidade e educação básica.