bluuebunny/crossref_metadata_2025 huggingface dataset:
Changes in Health Behaviour and Emotional Well-Being of Pregnant Women During the COVID-19 Pandemic in Latvia
Authors: Rezgale Roberta , Cauce Vinita , Bule Violeta , Piskurjova Anna , Meija Laila
Published: March 2022

Pregnancy is a vulnerable period of life for changes in physical and mental health, which could be exacerbated by COVID-19. The aim of this study was to assess the impact of COVID-19 on health behaviour and emotional well-being among pregnant women in Latvia. The cross-sectional study included 269 women: pregnant women in the third trimester and women until the 7th day post-partum. The study was conducted between July and October 2020, performed by a trained interviewer. Information regarding demographic, anthropometric data, self-assessment of changes in nutritional habits, daily physical activities, and emotional well-being due to the COVID-19 pandemic was collected. 31.6% reported cooking at home more often and only 10.4% reported eating more often and/or larger portions, 23.2% were going on walks outdoors more often, 32.9% were feeling anxious, insecure about health of themselves and relatives, and 24.8% were lacking communication with friends and family. Latvian women were emotionally more affected than other nationalities (p = 0.015). Overall, women 30+ years of age were more often affected then women aged up to 30 years (p = 0.014). These results suggest that the COVID-19 pandemic had notable impact on health behaviour and emotional well-being in pregnant women in Latvia, especially on women 30+ years of age, who may need more careful counselling.
Daily Time-Restricted Feeding And Alternative Day Fasting For Weight Management: Comparative Analysis
Authors: Lukstiņa Zane , Bodžs Bogdans , Ozoliņa-Moll Līga
Published: March 2022

The approach of limiting nutritional intake frequency, but without a large reduction of the amount of calories consumed, the so-called intermittent fasting, has gained growing popularity. Intermittent fasting is an umbrella term for meal timing schedules that cycle between voluntary fasting (or vastly reduced calories intake) and non-fasting over a defined period. In our study, we compared two of the most popular intermittent fasting regimens — 16/8 time-restricted feeding and 5/2 alternate day fasting. A total of 16 healthy young women (under 30 years of age) participated in the study, eight in each intermittent fasting group, for six consecutive weeks. Among anthropometric parameters, height, weight, umbilical waist circumference, sagittal abdominal diameter, and skinfold thickness were measured and body mass index and relative body fat were calculated. Differences between the initial values and the values after the six-week intermittent fasting period were calculated and compared between the two groups. We found no statistically significant difference (p > 0.05) between 16/8 time-restricted feeding and 5/2 alternate day fasting regimens in differences over the six-week period for the tested parameter, including weight loss. As there were no significant differences for overall changes in parameter values in the six-week period between the two intermittent fasting regimens, we concluded that both were equally suitable for weight loss programmes.
Polyprenol Liposomes Improve the Efficiency of Oxygen Usage in Well-Trained Amateur Athletes
Authors: Ušacka Laila , Plakane Līga , Vanaga Ilona , Klētnieks Kārlis , Jansone Baiba , Muceniece Ruta , Klētnieks Uģis , Pahirko Leonora
Published: March 2022

Polyprenols are natural substances that are known for their role as cell membrane protectors from peroxidation. However, there is a lack of information about their effect on the performance of athletes. Therefore, we studied the effects of polyprenol on athlete performance. A total of 30 male floorball players participated in this study, 16 of whom were taking 30 mg polyprenol liposome caps and 14 of whom were not. All of the participants underwent VO2max exhaustive incremental cycling testing, before and after the use of polyprenols. VO2peak and other cardiorespiratory variables were measured to evaluate cardiorespiratory adaptation. For the polyprenol users (PU) the oxygen pulse (O2/HR) increased by 0.9 ml/beat, while in the control group (C) decreased by 0.4 ml/beat from before to after the use of polyprenols (p < 0.05). The diastolic pressure (Pdia) decreased by 4 mmHg for the PU, while it increased by 10 mmHg in the C (p < 0.05). The stroke volume (SVc) in the PU increased by 2.9 ml, while that in the C decreased by 7.4 ml (p < 0.05). In conclusion, polyprenols improved oxygen consumption efficiency by increasing SVc and O2/HR.
Effect of Storage Conditions on Biologically Active Compounds in Purple-Fleshed Potatoes
Authors: Zariņš Reinis , Krūma Zanda , Skrabule Ilze
Published: March 2022

Potatoes (Solanum tuberosum L.) are an important crop. They are a source of natural phenolic compounds with high biological activity. Stress factors may decrease phenolic concentration and increase concentration of the toxin glycoalkaloid as a result of plant self-protection against stress. The aim of the current study was to evaluate the effect of storage under light on the concentration of biologically active compounds in purple-fleshed potatoes. The purple-fleshed potato variety ‘Blue Congo’ was harvested from test fields of the Institute of Agricultural Resources and Economics in Latvia. Storage under light was performed in a climate chamber ICH110 (Memmert GmbH + Co. KG, Germany) with constant pre-set relative air humidity 85%, temperature +22 °C, and full-spectrum light (Eecoo, 1200 W, LED) intensity of 2000 lux and total time seven days. Total phenolic concentration, antioxidant activity and total glycoalkaloid concentration was measured using spectrophotometry, and moisture was determined according to standard LVS 272:2000. Storage under artificial light of purple-fleshed variety ‘Blue Congo’ potatoes caused decrease of total phenolic concentration and antioxidant activity, no change in moisture level, and increase of total glycoalkaloid concentration.
Changes in Phenolic Profile and Antioxidant Activity of Horseradish Roots During Freezing and Frozen Storage
Authors: Tomsone Lolita , Galoburda Ruta , Krūma Zanda , Cinkmanis Ingmārs
Published: March 2022

Freezing is one of the ways to preserve plant products, because it allows inhibiting natural degradation and transformation processes of the bioactive compounds. The aim of this study was to evaluate the effect of freezing on bioactive compounds of horseradish roots and their dynamics in long-term frozen storage. Horseradish roots were frozen at two different conditions (–18±2°C and –40 ± 2 °C) and further stored at –18 ± 2 °C for 12 months. Total phenolic content (TPC), total flavonoid content (TFC), total flavonol content (TFlC), total flavan-3-ol content (TF3C), total phenolic acid content (TPAC), and radical scavenging activity (RedPow, DPPHÿ, ABTSÿ+) were determined spectrophotometrically. Individual phenolic compounds were deremined by liquid chromatography. The dominant individual phenolic compounds were phenolic acids (gallic and sinapic) and flavonoids (kaempferol, luteolin, and rutin). Because of freezing, TPC, TFC, and DPPHÿ as well as RedPow increased in horseradish roots. During storage, the content of analysed bioactive compounds mainly decreased. After 12-month storage, it was not possible to say unambiguously which of the freezing methods turned out to be better in general.
Sprouted Hulless Barley Grains and their Application Possibilities for the Functional Sweet Snacks Development
Authors: Šterna Vita , Segliņa Dalija , Krasnova Inta , Ķince Tatjana , Jansone Zaiga , Bleidere Māra
Published: March 2022

Currently, consumption of confectionery continues to grow, and there is a tendency to supplement snacks with ingredients that can be considered as functional products. The aim of this study was to evaluate the benefits of sprouted barley grains and their potential use in barley-fruit-vegetable snack production. Several samples of sweet bars with hulless barley variety ‘Kornelija’ flour and sprouted, crushed barley grain, dried fruit and vegetables were prepared. The chemical composition including the concentration of biologically active compounds (total concentration of phenols, flavonoids and tannins, as well as antioxidant activity) of untreated and sprouted grains was determined. The results showed that protein concentration of barley-fruit-vegetable bars varied from 8.65% to 10.85% and ß-glucans concentration varied from 0.77% to 2.19%. Their nutritional value varied from 1079.33 to 1430.41 kJ. Total fibre concentration of unsprouted, 24 h and 36 h sprouted grains was 26.30%, 25.80%, and 24.60%, respectively. Total phenol concentration of unsprouted barley grains was on average 273.14 mg·100 g−1 and flavonoid concentration was 290.25 mg·100 g−1, and for sprouted grains — 258.98 mg·100 g−1 and 256.19 mg·100 g−1, respectively. The evaluators preferred bars made from ground sprouted hulless barley grains ‘Kornelija’ — 7.4, according to the sensory analysis — hedonic scale.
Physicochemical and Rheological Properties of Non-Fat Ice Cream
Authors: Silantjeva Karīna , Zagorska Jeļena , Galoburda Ruta
Published: March 2022

Ice cream is a popular dessert in Latvia. At present, however, as consumers are watching their calorie intake, ice cream is starting to lose its leading position due to rich fat content. Therefore, development of low-fat or non-fat ice cream can provide a good alternative for consumers. At the same time, reduced fat is a challenge to a producer because it strongly affects the texture and sensory properties of ice cream. The aim of the current study was to assess the physicochemical and rheological properties of whey-based non-fat ice cream, depending on the ingredients used in the formulation. In total, 11 ice cream formulations were developed and evaluated, with differing proportions of the main ingredients. Chemical composition, hardness (after6hof hardening and subsequent two-week storage), overrun and rheological properties were analysed. Higher amounts of pumpkin puree, sugar and whey concentrate decreased the hardness of ice cream, and increased the overrun. Thus, higher proportions of pumpkin puree and whey concentrate significantly influenced product formulation by stabilising and strengthening air cells. Both an increased proportion of pumpkin puree and gelatine increased complex viscosity. There was a positive correlation between carbohydrate content and ice cream hardness after two-week storage, as well as between protein content and complex viscosity.
Disappearing Anomaly di Bursa Efek Indonesia
Authors: Sukawati A.A. Rai Niti Darmika , Wirama Dewa Gede
Published: March 2022

The purpose of this research is to analyze whether there is a disappearing anomaly on the Indonesia Stock Exchange, especially for the Monday effect and January effect. The analysis was carried out by comparing the two anomalies in two periods, namely 2011 to 2015 and 2016 to 2020. The study used a sample of companies that were consistently listed on the Kompas100 Index during the observation period, with a total sample consisting of 42 companies. The analysis technique used is a different test with independent sample t-test. The test results show that the Monday effect in the 2016-2020 period is significantly lower than the Monday effect for the 2011-2015 period, but there is no significant difference in the January effect in the two periods.

Keywords: Disappearing Anomaly, January effect, Monday effect.
Kualitas Laporan Keberlanjutan: Eksistensi dari Media dan Industri
Authors: Tizmi Salsabila , Luthan Elvira , Rahman Annisaa
Published: March 2022

The purpose of this study is to determine the effect of media and industry to the quality of sustainability report disclosure. Media is identified by online and social media. The amount of unfavorable news stories in Kompas and Detik is used to quantify online media. The amount of likes, comments, and tweets on Facebook, Twitter, and Instagram is used to quantify social media. The term industry refers to the sort of industry. GRI G4 Index is used to assess the sustainability report's disclosure. This study employs 37 firms as a sample that have gone public and are listed on the BEI in 2017-2020. Purposive sampling is used to determine the sample size.  The data analysis technique in this study uses multiple linear regression. The study's findings indicate that online media, social media, and industry type all have a major impact on the quality of sustainability report disclosure.

Keywords: Sustainability Report Disclosure; Online Media; Social Media; Type Of Industry.
Time Budget Pressure dan Audit Quality dengan Komitmen Profesional dan Supervisi Audit sebagai Variabel Moderasi
Authors: Padmawati Ni Putu Ida Rahayu , Dwirandra Anak Agung Ngurah Bagus
Published: March 2022

This study aims to obtain empirical evidence of the effect of time budget pressure on audit quality with professional commitment and audit supervision as moderating variables for auditors at public accounting firms registered in Bali Province. The sampling technique used is purposive sampling and obtained as many as 54 respondents. The study used data analysis techniques with Moderated Regression Analysis (MRA). Research shows that time budget pressure has a negative effect on audit quality, organizational commitment and audit supervision are able to weaken the effect of time budget pressure on audit quality at public accounting firms in Bali Province. This means that the higher the time budget pressure, the lower the audit quality, and the higher the professional commitment of an auditor and the existence of audit supervision quality.

Keywords: Time Budget Pressure; Professional commitment; Audit Supervision; Audit Quality.
Sustainability Report dan Manajemen Laba Dengan Good Corporate Governance Quality Sebagai Pemoderasi
Authors: Kepakisan I Gusti Agung Ayu Prabaningrat Dwi , Budiasih I Gusti Ayu Nyoman
Published: March 2022

The purpose of the study was to obtain empirical evidence regarding the effect of sustainability reports on earnings management and the effect of sustainability reports on earnings management with Good Corporate Governance Quality as moderating. The research was conducted at the Indonesia Stock Exchange, the data used is quantitative data. The data source of this research is using secondary data, the sample of this research is 10 companies with 5 years of research observation using purposive sampling method. The data were analyzed using moderate regression. The results of the study show that the sustainability report has a negative effect on earnings management and Good Corporate Governance Quality strengthens the negative effect of the sustainability report on earnings management. This is based on the Legitimacy and Agency theory, where the occurrence of earnings management can be influenced by Good Corporate Governance Quality. The higher the level of Good Corporate Governance Quality achieved by the company, it can suppress the occurrence of earnings management. Therefore, the higher the level of Good Corporate Governance Quality of a company, the greater the disclosure of the sustainability report by the company.

Keywords: Profit; Profit Management; Sustainability Report; Quality of Good Corporate Governance.
Writing the History of the Dieppe Raid: The British-Canadian Historical Liaison Relationship in Five Documents
Authors: Hamilton Megan
Published: March 2022

The work of official historian Charles P. Stacey played a foundational role in shaping the historiography of Canada in the Second World War. A lack of access to important archival material guarded by the British Cabinet Office, however, impeded Stacey’s ability to produce the early histories of the war. A struggle for access lasted from late 1947 until 1950; one that would involve diplomatic maneuvering on both sides of the Atlantic. With its convoluted historical record, the 1942 Dieppe Raid acts as an interesting case study to assess the impact of this fight for information. These historical documents and the accompanying commentary highlight the challenges Stacey experienced as he navigated the British-Canadian historical liaison relationship to piece together the origins and objectives of the raid.

Les travaux de l’historien officiel Charles P. Stacey ont joué un rôle fondamental dans l’élaboration de l’historiographie du Canada pendant la Seconde Guerre mondiale. Toutefois, le manque d’accès à d’importants documents d’archives gardés par le British Cabinet Office a entravé la capacité de Stacey à produire les premières histoires de la guerre. La lutte pour l’accès, qui a duré de la fin de 1947 jusqu’en 1950, allait engager des manoeuvres diplomatiques des deux côtés de l’Atlantique. En raison de son bilan historique alambiqué, le raid sur Dieppe de 1942 constitue une étude de cas intéressante qui permet d’évaluer les répercussions de cette lutte pour obtenir des informations. Ces documents historiques et les commentaires qui les accompagnent mettent en évidence les défis que Stacey a dû surmonter alors qu’il étudiait les liens historiques entre l’Angleterre et le Canada afin de reconstituer les origines et les objectifs du raid.
Landslide variation with morphometric factors using the GIS techniques: The case of Shaqlawa Forest
Authors: Zaki Sara H. , Suleimany Jehan M. Sheikh
Published: March 2022

This study deals with the application of geographical information system (GIS) datasets and methods to assess the landslide susceptibility in Wadi Hujran. The area has a rocky terrain and belongs to the Shaqlawa district of the Kurdistan Region of Iraq. The region is placed towards the Northeast side of Erbil city. The region covers an area of 18.56 Km2 (1856.1 ha) and consists of rough broken and stones. The watershed area is surrounded by North latitudes 36° 21' 53.514" to 36° 17' 49.7796" and East longitudes 44° 17' 5.658" to 44° 20' 9.06". Three factors, namely the morphometric, geological, and environmental, were used to prepare the landslide susceptibility index. The study made use of AHP method and prepared a landslide susceptibility map. Data related to geology, topography, hydrology, rainfall, and land use were used to prepare the map. Physical and statistical methods were used to validate the map. A heuristic approach was incorporated to produce the final susceptibility map. ArcGIS software was used to generate the landslide zones. A total of five landslide zones were generated, which varied from very low landslide zones (80.5) to very high landslide zone (84.5). The zones also included low landslide zone (1262.2), moderate landslide zone (1505.9), and high landslide zone (566.8), and the ratio of consistency in the present study was 0.06 AHP less than 1, and all the five zones in the study were compiled landslide zonation estimated.
Determining The Paths of Urban Expansion for The City of Kirkuk Using The Hierarchical Analysis – Multi - Criteria Decision - Making Method
Authors: Naser Ibrahim J. , Falih Moheb K. , Alssayed Mohamed M.
Published: March 2022

The research aims to choose the paths of urban expansion byadopting a correct scientific approach that enhances themethodology of spatial analysis of the most appropriate sitesby studying indicators that affect the city, and since thehierarchical analysis method is a scientific method, i.e. the twowaycomparison process, the comparison of couples is the onewho reaches the relative weights of factors or Indicators andevaluation. Therefore, spatial decision-making usuallyincludes many criteria that reflect the opinions and decisionsof decision-makers, experts, interested parties andstakeholders to determine the paths of urban expansion, andbecause of these multiple opinions and decisions, all thesematters must be resolved through the adoption of a strategy ofdirect integration into the environment of information systemsprograms. The geographical representation of the results of thehierarchical analysis, which was based on the weights of allfactors, i.e. the main and sub-indicators obtained from theExpert Choice program, which worked on the integration andintegration of multi-criteria capabilities by creating anintegrated integrated unit, which proved to provide andprovide practical and scientific solutions to decision makers inthe least possible time and cost. Effort as well as its ability andcompetence to provide technical support to planning decisionmakers. Through what we mentioned in the study of assessingthe spatial suitability of urban expansion, we obtained theresults of the most appropriate, most and least appropriate forthe areas of determining the paths of urban expansion in thecity of Kirkuk.
USING PORTRAITS OF N-NORMS FOR LARGE-SCALE INVESTIGATION OF CIRCUITS WITH MODAL RESERVATION
Authors:   HSE University Moscow, Russia, Gazizov R. R. , Medvedev A. V. ,   Tomsk State University of Control Systems and Radioelectronics, Tomsk, Russia, Gazizov T. R. ,   Tomsk State University of Control Systems and Radioelectronics, Tomsk, Russia
Published: March 2022

В работе предложено усовершенствовать процесс массового исследования цепей с модальным резервированием. Это показано на примере двухсторонней печатной платы с полигонами. В качестве среды моделирования использовалась компьютерная система TALGAT. Получено по 5 различных портретов (значений вдоль проводника) N-норм для каждого из трех сигналов: трапециевидного сверхкороткого импульса, реального сверхкороткого импульса и электростатического разряда. Приведены максимальные и минимальные значения N-норм. Выявлены особенности поведения зависимостей. При анализе результатов моделирования выявлено большое количество увеличений значений N-норм вдоль проводника относительно уровня на входе. Предложено использование портретов N-норм для быстрой формализованной оценки наличия особенностей распространения сигналов в исследуемых цепях. Данная работа является частью массового исследования цепей с модальным резервированием, при котором рассматривались 5 различных структур для модального резервирования.
BUILDING A MESH NETWORK MODELWITH THE TRAFFIC CACHING BASED ON THE P2P MECHANISM
Authors:   LLC «ARENADATA SOFTVER», Moscow, Russia, Zharikov A. V. , Konstantinova O. V. ,   FSBEI of HE Altai State University, Barnaul, Russia, Ternovoy O. S. ,   FSBEI of HE Altai State University, Barnaul, Russia
Published: March 2022

В статье решается задача о нахождении контента, который уже запрашивался пользователями в mesh-сети, в которой находятся маршрутизаторы с возможностью кэширования контента. Сеть строится на основе взаимодействия P2P (peer-to-peer). Мesh-сеть рассматривается как неориентированный граф, заданный матрицей весов, где под весом понимается пропускная способность между двумя роутерами. Предложенная в статье математическая модель позволяет построить маршрут с наибольшей скоростью доступа до запрашиваемого содержимого с помощью модифицированного алгоритма Дейкстры, причем, если требуемый контент отсутствует в кэше mesh-сети, то маршрут строиться через роутеры с доступом к сети Интернет. С практической точки зрения рассматриваемый способ создания маршрутов к контенту, который уже запрашивался пользователями в mesh-сети, позволяет оптимально эффективно использовать распределение пропускной способности роутеров.
AN UPGRADED METHOD FOR MEASURING THE ELECTRIC FIELD STRENGTH BY THE AVERAGE VALUE OF DUAL SENSORSAND DEVICES FOR ITS IMPLEMENTATION
Authors:   Omsk State Technical University, Omsk, Russia, Biryukov S. V. , Tyukina L. V. ,   Omsk State Technical University, Omsk, Russia
Published: March 2022

В работе анализируется метод измерения напряженности электрического поля по среднему значению. Выявляются его достоинства и недостатки. С учетом выявленных недостатков предлагается модернизированный метод с использование сдвоенного датчика и встроенного в него измерительно-вычислительного устройства, позволяющего непосредственно получать результат измерения напряженности электрического поля. Для реализации модернизируемого метода измерений в устройствах для измерения напряженности электрического поля анализируются с позиции минимума погрешности и пригодности для модернизированного метода различные виды электроиндукционных датчиков, из которых выбираются сдвоенные датчики. Использование сдвоенных датчиков и модернизированного метода в предложенных устройствах для измерения напряженности электрического поля позволяет свести погрешность измерения до (2 5) %. Предложенные устройства для измерения напряженности электрического поля позволяют получить результат измерения в виде эквивалента напряженности электрического поля точечного заряда.
RESEARCH OF THE INFLUENCE OF THE OPTICAL FIBER STRUCTURE ON THE CHARACTERISTICS OF ACOUSTO-OPTIC INTERACTION
Authors:   Omsk State Technical University, Omsk, Russia, Bogachkov I. V. , Maistrenko V. A. ,   Omsk State Technical University, Omsk, Russia, Gorlov N. I. ,   Siberian State University of Telecommunications and Computer Science, Novosibirsk, Russia
Published: March 2022

В этой работе приведены результаты исследований влияния структуры одномодовых оптических волокон различных видов на характеристики взаимодействия основной оптической моды с акустическими модами низших порядков. Рассмотрена методика получения распределения оптических и акустических мод в одномодовых оптических волокнах. Представлены структуры радиального распределения профилей показателя преломления для некоторых разновидностей одномодовых оптических волокон. Приведены полученные графики для распространённых разновидностей одномодовых оптических волокон.
OPTIMIZATION OF THE PROCEDURE FOR NORMALIZATION AND BIAS OF INPUT DATA FOR MEDIUM HARMONIC NEURONS USED IN TESTING THE HYPOTHESIS OF THE NORMAL DISTRIBUTION OF SMALL SAMPLES
Authors:   Penza State University, Penza, Russia, Lukin V. S. , Ivanov A. I. ,   Penza State University, Penza, Russia
Published: March 2022

При автоматическом обучении нейросетевых преобразователей биометрии в код биометрической аутентификации по ГОСТ Р 52633.5 необходимо проверять гипотезу нормального распределения входных биометрических данных. Использование для этой цели хи-квадрат критерия дает значительный уровень ошибок при обучающих выборках в 16 примеров. При переходе к использованию критерия среднего гармонического удается снизить вероятность появления ошибок в 3.7 раза. Оптимизация процедуры нормирования и смещения входных данных позволяет дополнительно снизить вероятность появления ошибок, примерно, в два раза.
Instrumentelle Methoden der anorganischen Elementanalytik
Authors: Kläntschi Niklaus
Published: March 2022

Instrumental element analysis has developed enormously during the past decades. It has rightfully assumed a major role in the analytical laboratory in the field of materials science, environmental analysis, monitoring and research. Due to its high accuracy, classical chemical analysis
is still most useful for elemental determinations at major levels and for special applications. In a modem inorganic analytical laboratory, a variety of different instmmental techniques is employed for qualitative and quantitative analysis, covering practically all the elements of the periodic
system in a variety of different matrices, from major to trace and ultratrace mass levels. The prerequisite for atomic spectroscopy is the step of excitation, normally in combination with a process of atomization. From a number of different atomization processes currently used, inductively
coupled plasma (ICP) is now the most prominent. The atomic spectrometric methods commonly employed in an analytical laboratory are described. These include atomic absorption, both with flame and graphite furnace, ICP atomic emission and ICP mass spectrometry, X-ray fluorescence together with
ion chromatography as a non-spectrometric analytical process. The different instrumental techniques are critically compared in relation to number of detectable elements and species, limits of detection, precision, sample throughput, dynamic concentration range, degree of automation, and cost
of equipment. Moreover, the importance of sampling and sample treatment prior to the analytical determination, quality assurance, and mode of automation are related both to the present situation and future trends in instrumental element analysis.
Die Bedeutung von Qualitätssystemen heute und in den 90er Jahren
Authors: Walter Robert
Published: March 2022

Qualitätssieherung, Qualitätssysteme und die Zertifizierung von Qualiäitssystemen haben nicht zuletzt dank der neuesten Entwieklungen in Europa und in anderen Teilen dieser Welt eine ganz neue und viel grössere Bedeutung gewonnen. Eine Dimension, welche immer mehr Firmen dazu veranlasst, ihre konkurrenziellen und qualitativen Fähigkeiten entscheidend zu verbessern.
Pembrolizumab Induced Grade 4 Skin irAEs with NonSmall Cell Lung Cancer: Case Report and Review of Literature
Authors:   Department of Oncology, Xiangya Hospital, Central South University, Changsha, PR China, Zhou Pengyu , Zhang Jing ,   Department of Oncology, Xiangya Hospital, Central South University, Changsha, PR China, Tan Zhaohua ,   Department of Oncology, Xiangya Hospital, Central South University, Changsha, PR China, Tang Jianbing ,   Department of Oncology, Xiangya Hospital, Central South University, Changsha, PR China, Li Bin ,   Department of Oncology, Xiangya Hospital, Central South University, Changsha, PR China, Peng Haiqin ,   Department of Oncology, Xiangya Hospital, Central South University, Changsha, PR China, Zhang Jing ,   Department of Oncology, Xiangya Hospital, Central South University, Changsha, PR China, Zhou Rongrong ,   Department of Oncology, Xiangya Hospital, Central South University, Changsha, PR China, Zhou Chuanyi ,   Department of Oncology, Yueyang People’s Hospital, Yueyang, PR China
Published: March 2022

Objectives: Immune Checkpoint Inhibitors (ICIs), including pembrolizumab, have exhibited substantial benefits in the treatment of several types of cancers. However, treatment with ICIs is often accompanied by immune-related adverse events (irAEs), we report a rare case of pembrolizumab induced grade 4 skin irAEs with non-small cell lung cancer (NSCLC). Materials and Methods: We report about an advanced NSCLC patient with 4 grade skin irAEs, after the treatment of pembrolizumab. We also compared statistical laboratory results and imageological examinations to discuss the relative factors of the patient’s curative effect and adverse reactions. Results and Conclusion: This case is the first report of a 4-degree skin reaction with the pembrolizumab in patients with NSCLC, and the patient has the characteristics of good curative effect and severe adverse reactions. The patient experienced grade 4 skin irAEs after five cycles of pembrolizumab. Increased eosinophil levels are associated with increased skin irAEs in patients. However, CEA and Cytokeratin 19 fragment changes did not show a significant correlation with their skin irAEs and efficacy. The study of this case can provide some reference for efficacy evaluation and treatment after severe skin irAEs in patients with NSCLC.
Predicting MDM2 Amplification in Well-Differentiated Liposarcomas
Authors:   Department of Surgery, Melbourne Medical School, University of Melbourne, Melbourne, Victoria, Australia, V Tran , J Slavin ,   Department of Anatomical Pathology, St. Vincent’s Hospital, Melbourne, Victoria, Australia, T Spelman ,   Department of Surgery, Melbourne Medical School, University of Melbourne, Melbourne, Victoria, Australia, D May ,   Department of Orthopaedics, St. Vincent’s Hospital, Melbourne, Victoria, Australia, PFM Choong ,   Department of Surgery, Melbourne Medical School, University of Melbourne, Melbourne, Victoria, Australia
Published: March 2022

Background: Well-Differentiated Liposarcoma (WDLPS) is the most common subtype of malignant lipomatous tumours. This low-grade neoplasm carries a risk of local recurrence and dedifferentiation into higher-grade subtypes, and therefore requires aggressive treatment with wide local excision and neoadjuvant radiotherapy. WDLPS, however, shares overlapping features with its benign counterpart, lipoma. Diagnostically challenging cases can be resolved with molecular testing for Mouse Double Minute 2 (MDM2) amplification, which is found in almost all WDLPS. This study aimed to determine the predictors of MDM2 amplification to better inform the decision for tumours to undergo molecular testing. Methods: A retrospective study was performed on 173 lipomatous tumours. Demographic, clinical, radiology and pathology data were obtained from institutional records. Multivariate analysis was performed to determine the features of lipomatous tumours that correlate with MDM2 amplification. The relative strength of the associations between predictor variables and MDM2 amplification were measured via derivation of coefficients of determination (Pseudo-R2). Results: The significant predictors of MDM2 amplification were age of diagnosis ≥60 years (odds ratio (OR)=25.71; 95% confidence interval (CI)=4.47- 148.02); size ≥15cm (OR=11.68; 95% CI=2.70-50.59); presence of thick septa (OR=78.13; 95% CI=3.23-1890.71) on MRI; variable cell morphology (OR=22.19; 95% CI=4.03-122.20); and cytological atypia (OR=15.03; 95% CI=3.07-73.68). Conclusion: Molecular testing for MDM2 amplification should be considered for tumours 15cm or greater, in patients aged 60 years or older, with thick septa on MRI, even in the absence of concerning histological features.
Approach to Strabismus
Authors: Dhoot Arjan , Wan Michael
Published: March 2022

Strabismus is characterized by a misalignment of the eyes.  A thorough history and physical examination should be performed by clinicians when strabismus is suspected. The Hirschberg, cover, cover-uncover, and alternate prism cover tests are commonly used to identify and diagnose strabismus. Strabismus usually requires a referral to an ophthalmologist. Treatment of strabismus involves eye patches, cycloplegic drops, prescription glasses, and surgery. Strabismus can result in vision loss due to amblyopia and may also cause double vision, psychosocial concerns, and impaired depth perception.
Formulation and In Vitro/In Vivo Evaluation of Metoclopramide Mucoadhesive Buccal Patches for Effective Pain Management
Authors: Prakash Gnana
Published: March 2022

The report planned to design plus valuate mucoadhesive buccal patches of Metoclopramide for orthopedic treatment of pain and inflammations. All eight formulation acquire numerous evaluation parameters, it used to be complete for which F1 confirmed good mucoadhesive strength, encouraging pressurized and arrant drug release, easiest In-vivo residence time, swelling index and pH shows the best formulation. The acquired in vivo effects show that the put concentration of Metoclopramide in the mouth cavity was retained above 5 pg/mE for 130 min. The effect stands for so the buccal patches of metoclopramide could be a good choice to avoid the unsatisfactory systemic unwanted effects and will be planned as a new therapeutic tool around against orthopedic diseases and disturbances.
HUBUNGAN FUNGSI KOGNITIF DAN KONDISI KESEHATAN DENGAN DEPRESI PADA PASIEN HIV/AIDS DI RSUD RA KARTINI JEPARA
Authors: Pertiwi Fita Hana , Indanah Indanah , Himawan Rizka
Published: March 2022

Abstrak Kasus depresi pada pasien dengan HIV/AIDS ini diperkirakan mempunyai frekuensi mencapai 60% dari total kasus depresi yang ada. Kejadian depresi terkait dengan gangguan fungsi kognitif dan penurunan status fungsional. RSUD RA Kartini merupakan rumah sakit rujukan untuk penanganan pasien dengan HIV / AIDS khususnya di Jepara, pada tahun 2018 terdapat 4917 kunjungan di Poli Matahari. Tujuan penelitian ini adalah untuk mengetahui hubungan antara fungsi kognitif dan kondisi kesehatan dengan depresi pada pasien HIV/ AIDS di RSUD RA Kartini Jepara. Jenis penelitian ini adalah Observasional bersifat deskriptif korelasional dengan menggunakan metode pendekatan cross sectional. Populasinya adalah pasien pengunjung Poli Matahari RSUD RA Kartini Jepara dengan jumlah sampel sebesar 78 orang. Alat ukur yang digunakan adalah kuesioner dan lembar observasi. Hasil Penelitian meunjukkan adanya hubungan  penurunan fungsi kognitif dengan depresi pada pasien HIV/AIDS di Poli Matahari RSUD RA Kartini Jepara dengan nilai p = 0,001 < α 0,05 dan nilai r sebesar 0,383. Adanya hubungan penurunan kondisi kesehatan dengan depresi pada pasien HIV/AIDS di Poli Matahari RSUD RA Kartini Jepara dengan nilai p = 0,000 < α 0,05 dan nilai r sebesar 0,421. Kesimpulan hasil penelitian adalah ada hubungan antara fungsi kognitif dan kondisi kesehatan dengan depresi pada pasien HIV/ AIDS di RSUD RA Kartini Jepara. Kata Kunci : Depresi, Fungsi Kognitif, Kondisi Kesehatan, HIV/AIDS Abstract Depression cases in patients with HIV / AIDS is estimated to have a frequency of up to 60% of the total depression cases. The incidence of depression is associated with impaired cognitive function and decreased functional status. RSUD RA Kartini is a referral hospital for the treatment of patients with HIV / AIDS, especially in Jepara, in 2018 there were 4917 visits to Poli Matahari. This study is to know the relationship between cognitive function and health conditions with depression in HIV / AIDS patients at RA Kartini Hospital, Jepara. This type of research is observational descriptive correlational using a cross sectional approach. The population is the patient visiting Poli Matahari RSUD RA Kartini Jepara with a total sample of 78 people. The measuring instruments used were questionnaires and observation sheets. Result of this study is a relationship between cognitive decline and depression in HIV / AIDS patients at the Poli Matahari Hospital RA Kartini Jepara with a value of p = 0.001 <α 0.05 and an r value of 0.383. There is a relationship between a decrease in health conditions and depression in HIV / AIDS patients at the Poli Matahari Hospital RA Kartini Jepara with a value of p = 0.000 <α 0.05 and an r value of 0.421. There is a relationship between cognitive function and health conditions with depression in HIV / AIDS patients at RA Kartini Hospital, Jepara. Keywords : Depression, Cognitive Function, Health Conditions, HIV / AIDS
User Acceptance of Google Classroom-Assisted Learning: The Case of Malaysian Form Six Economics Students
Authors: Sari Noornadiah Md. , Yin Khoo Yin , Zakariya Zainizam , Ismail Ramlee
Published: March 2022

As a result of the COVID-19 pandemic situation, educators in Malaysia have resorted to the use of the learning medium Google Classroom as an alternative to existing online teaching methods. Past studies have focused on direct and indirect factors towards the intention to use and the use of Google Classroom in public institutes of higher learning. This study therefore aimed to identify the level and tendency of acceptance items of Google Classroom-assisted learning among Form Six economics students based on demographic factors. A questionnaire was distributed to 206 students in the state of Melaka, Malaysia. Descriptive analysis was used to measure the level of user acceptance of Google Classroom, and the Rasch measurement model of differential item functioning (DIF) was used to identify the tendency of items based on demographic factors. From the findings of the study, the overall analysis of student acceptance of Google Classroom showed that it was at a moderately high level. DIF analysis proved that there were differences in the propensity to adopt Google Classroom based on gender, ethnicity, experience, and frequency of internet usage. The findings of this study will help policymakers to issue guidelines, and assist school management and teachers to plan for technological literacy training to educate students in schools.
Etnosentrizm, Kozmopolitanizm, Çeşitlilik Arayışı Ve Kişisel Yenilikçiliğin Yabancı Menşeili Fast Food Restoranlardan Satın Alma Niyetine Etkisi: Yabancı Marka Ülke İmajının Düzenleyici Rolü
Authors: DOĞRUL Ümit
Published: March 2022

Küreselleşmeyle birlikte tüketim kalıplarının gün geçtikçe birbirine benzemesi gıda sektöründe yer alan işletmelerin dış pazarlara daha çok açılmasını teşvik etmiştir. Türkiye’ de de özellikle son yıllarda küreselleşme ve göçün etkisiyle birçok yabancı menşeili fastfood restoran açılmıştır. Ancak bu restoranların bir kısmı yerel tüketiciler tarafından istenilen talebi görememektedir. Bu çalışmanın amacı çeşitlilik arayışı, kişisel yenilikçilik, kozmopolitanizm ve etnosentrizmin yabancı menşeili fastfood restoranlardan hizmet almaya etkilerini ortaya koymaktır. Ayrıca, çalışmada yabancı marka ülke imajının bu etkiler üzerindeki düzenleyici etkilerini belirlenmeye çalışılmıştır. Bu çerçevede oluşturulan anketler yüz yüze ve online anket yöntemiyle 411 kişiye uygulanmış ve araştırma kapsamında belirlenen hipotezler PLS-SEM ve PLS-MGA analizleri ile test edilmiştir. Analiz sonuçlarına göre çeşitlilik arayışı, kişisel yenilikçilik, kozmopolitanizmin yabancı fastfood restorandan hizmet alma niyetini olumlu yönde etkilediği belirlenmiştir. Etnosentizmin ise yabancı fastfood restoranttan hizmet alma niyetini olumsuz etkilediği ortaya konmuştur. Ayrıca restoranın menşei ülkesinin marka imajına göre çeşitlilik arayışı, kozmopolitanizm ve etnosentirizmin satın alma niyeti arasındaki ilişkilerin farklılaştığı belirlenmiştir. Yabancı ülke imajı düşük olduğunda bu üç değişkenin satın alma niyetini daha fazla etkilediği saptanmıştır.
A first step to task design in computer-based L2 listening: Task characteristics elicitation
Authors: Cardenas-Claros Monica S. , Dassonvalle Kimberley
Published: March 2022

Research on CALL has witnessed a renewed interest in task design as evidenced by the number of peer-reviewed publications and conference presentations that link task design to technology. This interest has also translated into a surge of studies addressing task design with a focus on output-based tasks such as L2 writing and L2 speaking. However, as in other areas of research in English Language Teaching, task design in L2 listening remains under-researched. The qualitative case study reported here is the first stage of a three-stage research study that aims to put forward a theoretically-and-an-empirically-based framework for the design of tasks in computer-based L2 listening environments. Accordingly, we elicited the personal goals of listeners of English as a foreign language with a view to identifying characteristics of computer-based L2 listening tasks. The participants are 68 high-school students from public and semi-public schools in Chile. Using established techniques for data collection from an Educational Engineering perspective (Colpaert, 2010) the data comes from an entry-questionnaire and three focus group sessions where participating students explored, reflected, shared their personal goals and their expectations about tasks for computer-based L2 listening environments. The verbal data were transcribed, analyzed and emerging characteristics identified. Characteristics of computer-based listening tasks are grouped and presented as three components: input, task structure, and levels of support and guidance. Results are discussed along with integrated data.
Military fi eld and naval therapy from the origins to the present day. Рart 2
Authors: Simonenko V. B. , Abashin V. G. , Dulin P. A.
Published: March 2022

The article represents brief information about the origin and development of therapeutic care in the Russian Army and Navy. The gradual transformation from the «Army Clinic» of Prof. M.Ya. Mudrov to the medical discipline «Military fi eld therapy» («Naval therapy») is described. The data on the development of military fi eld therapy during the military confl icts of the late 1930s, the Great Patriotic War and the post-war period are presented.
The risk of cardiac and cerebrovascular complications in patients with concomitant cardiovascular diseases who have had COVID-19
Authors: Klyachina E. S. , Smolenskaya O. G.
Published: March 2022

During the pandemic caused by the SARS-CoV-2 virus, patients with cardiovascular diseases (CVD), which are often found in the population, are a special risk group. Cardiovascular complications after COVID-19 can occur at diff erent periods of the disease. This research describes cardiovascular complications in patients after recovery.

The aim of the study was to identify the incidence of new CVD and complications of existing cardiac pathology in patients who recovered from COVID-19.

Material and methods. A retrospective, observational study including 370 patients was conducted. All patients underwent telephone consultations within 6 months after the infectious diseases hospital discharge. When new CVDs, complications or anabasis were identifi ed, follow-up visits were initiated.

Results. Among 370 patients under the study, concomitant CVD was registered in 249 (67.29%) people, 121 (32.71%) patients had no case history of cardiovascular pathology. In patients with concomitant CVD during the fi rst 6 months after the infectious diseases hospital discharge, 25 (10.04%) new cardiovascular events were registered, which is signifi cantly more frequent than in patients without case history of CVD (n = 1; 0.83%). The number of events described above was more often observed in the fi rst 3 months after discharge, which is statistically signifi cant (p ˂ 0.05). BP destabilization was most often observed (n = 67; 27.2%) as anabasis, which may be associated with an increased level of anxiety in patients. It was also noted that new CVDs, as well as anabasis, developed because of the timely specialized cardiological medical care absence, which probably led to undesirable events due to inability to correct CVD risk factors in time.

Conclusions. In patients with concomitant CVD, who have had COVID-19, in contrast to patients without case history of CVD, the risk of developing new cardiovascular events is signifi cantly higher. Patients with CVD deserve the closest attention during the fi rst 3 months after discharge from the infectious diseases hospital.
About the status of an army medical officer
Authors: Kraynyukov P. E. , Simonenko V. B. , Abashin V. G. , Dulin P. A. , Gaivoronskikh D. I.
Published: March 2022

The article presents the events of 1912–1913 that took place during the restructuring of the Military Medical Academy and the formation of the status of an army medical officer. The historical information about the role and duties of army medical officers in the Russian Imperial Army before the First World War is given.
Student book based on Coastal natural resources: A development research to raise student pro-environmental character
Authors: Kasim Yulan , Katili Abubakar Sidik , Nusantari Elya
Published: March 2022

The research aims to develop student books based on the potential of coastal areas to improve students' pro-environmental character. Research and development from Sugiyono was used to develop student book. as many as 10 students participated in the product trial. Two experts and one practitioner validated using a validation sheet. Measurement of pro-environmental character using pro-environmental character test. Analysis of pro-environmental characters using n-gain. The results showed that the student's book met the valid criteria (88.77%), increased the pro-environmental character of students at the medium - high level (0.33 - 0.74), and received a very good response (88% - 100%) from the students. This research concludes that the student's book based on coastal natural resources meets the valid criteria, improves the character of the environmental profile and gets a very good response. Further research to test the effectiveness needs to be done through use trials.