bluuebunny/crossref_metadata_2025 huggingface dataset:
Prognostic factors associated with survival in patients with anaplastic oligodendroglioma. v1
Authors: Zhuang Weiduan , Liu Shuo
Published: December 2018

Background Anaplastic oligodendroglioma (AO) is a rare disease with inadequately understood prognosis. The aim of this study is to investigate factors associated with survival outcome in AO patients. Methods A population-based cohort study was conducted based on the Surveillance, Epidemiology, and End Results (SEER) program. Patients with histological diagnosis of AO from 1973 to 2015 were included. Results 1899 AO patients were included in our study. Mean age of diagnosis was 49.2 years and 56.19% were male. 62.40% of patients were married and 87.05% were white. Most patients (90.42%) were diagnosed with AO as their first malignant primary tumor. 87.89% of patients had received cancer-directed surgery. Patients receiving surgery had a better prognosis for overall survival (OS) compared to those not receiving surgery after propensity score matching (PSM) analysis (p<0.05). The overall 1-, 3-, 5- and 10-year survival of AO was 78.7%，60%，50.2% and 36.2% respectively. Kaplan-Meier analysis indicated that age, marital status, first malignant primary indicator and surgery were associated with OS whereas sex and race were not. Moreover, an age value of 52 years was calculated as an optimal cutoff value to distinguish better and worse OS. Multivariate Cox proportional hazard analysis indicated that older age (OR 1.040, 95%CL 1.035-1.045), single patients (OR 1.293, 95%CL 1.103-1.515) and AO being not first malignant primary tumor (OR 1.501, 95%CL 1.238-1.820) were significantly associated with worse OS whereas surgery (OR 0.584, 95%CL 0.494-0.689) was associated with better OS. Moreover, a nomogram predicting 5- and 10-year survival probability for AO was constructed based on these variables. Conclusion Age, marital status, first malignant primary indicator and surgery were associated with survival of AO.
Docosahexaenoic acid in the treatment of male infertility
Authors: Vinogradov I. V. , Zhivulko A. R. , Vinogradova L. M. , Korolev S. V.
Published: December 2018

Literature review is devoted to the analysis of modern data on the use of docosahexaenoic acid in the treatment of male infertility. A brief description of modern ideas about the possible causes of male infertility (a disturbance of function of the cell membrane and genetic damage of sperm) was conducted. The data on the anti-inflammatory properties of omega-3 polyunsaturated fatty acids are described in detail. The bioavailability of docosahexaenoic acid and the choice of drugs containing it for the treatment of male infertility are discussed. Increasing the content of polyunsaturated fatty acids, in particular docosahexaenoic acid, in the sperm membrane was associated with higher ejaculate quality. Therapy with the use of these substances led to the improvement of standard indicators of semen and a decrease in the proportion of sperm with fragmented DNA.
May-Thurner syndrome and varicose veins of the pelvic organs in men
Authors: Kapto A. A.
Published: December 2018

The study objectiveis to study the methods of diagnosis and treatment of iliac venous compression in men with urological and andrological pathology and varicose veins of the pelvic organs.

Materials and methods. From 2015 to 2018, 110 patients with bilateral varicocele, varicose veins of the pelvic organs and May–Thurner syndrome in age from 17 to 69 years (mean 33.2 years) were examined. Ultrasound echography of the scrotum organs and vessels of the penis, including transrectal and Doppler mode, magnetic resonance phlebography, dynamic pharmacocavernosography were used for the examination.

Results.The presence of bilateral varicocele in all patients was verified. Aorto-mesenteric compression in combination with iliac venous compression was detected in 36 (32.7 %) patients. X-ray surgical treatment of ileal venous compression syndrome was performed in 26 patients. After 3 months in all cases there was a decrease in the maximum diameter of the veins of the prostate gland. In 13 patients with isolated ileal compression (without combination with arterial aorto-mesenteric forceps), by 3 months after surgery, a reduction in varicocele was observed: in all cases the diameter of the left and right testicular veins lying and without tension was less than 2 mm.

Conclusion.Angioplasty and stenting of the iliac veins in arterio-venous conflicts is a highly effective method of treating patients with varicose veins of the pelvic organs in combination with varicocele.
Phytopreparations in complex treatment of patients with benign prostatic hyperplasia and erectile dysfunction
Authors: Bat’ko A. B.
Published: December 2018

The study objectiveis to evaluate clinical effectiveness of a phytopharmaceutical Vialissil® for treatment of patients with benign prostatic hyperplasia (BPH) and erectile dysfunction.

Materials and methods. At the multi-specialty clinic “Family Doctor” (Saint Petersburg) 34 patients aged from 55 to 67 years (mean age 59.6 + 0.7 years) with BPH and concomitant erectile dysfunction without the need for surgical intervention were examined. All patients received previously prescribed symptomatic therapy for BPH and erectile dysfunction (a-adrenoblockers and phosphodiesterase type 5 inhibitors on demand). The treatment group included 18 patients who additionally received Vialissil® as capsules once a day for 30 days. The remaining 16 patients were the control group.

Results.After treatment, intensity of general symptoms decreased more in the treatment group than in the control group (by 10 and 4 points, respectively). After the course of therapy, erectile function improved in both groups but only in the treatment group these dynamics were statistically significant. An increase in testosterone level was statistically significant only after combination therapy with Vialissil® (by 16.5 %), and blood level of biologically accessible (active) testosterone increased twofold.

Conclusion.Combination therapy for BPH and erectile dysfunction including administration of the Vialissil® phytopharmaceutical more effectively decreases disease intensity compared to standard therapy.
Connection of urethral microbiota with the semen quality and the concentration of endocrine disrupters in men semen
Authors: Chigrinets S. V. , Bryuhin G. V.
Published: December 2018

The study objective is to investigate the correlations between opportunistic microorganisms of the urethra and the quality of ejaculate, as well as the concentration of ubiquitory endocrine disruptors (bisphenol A and triclosan) in men semen.

Materials and methods. We analysed 63 semen samples of men with normo- and patozoospermia. In seminal fluid the concentration of bisphenol A and triclosan was determined by gas chromatography with mass spectrometry. The microbiocenosis of the urethra was studied by real-time polymerase chain reaction using the Androflor test system. The results were subjected to statistical processing using the Mann — Whitney U-test and correlation analysis. A p-value less than 0.05 was considered significant.

Results. Bisphenol A was found in 100 % of the semen samples. Triclosan was detected in 84.9 % of the samples. Comparison groups on the quality of ejaculate (normo- and pathozoospermia) were statistically significantly different in the concentration of bisphenol A and triclosan in seminal fluid (p <0.001) and (p = 0.003) respectively. The study established statistically significant correlations between bisphenol A concentration, seminal triclosan and urethral microbiota: Lactobacillus spp. (r = 0.501, p = 0.003), Corynebacterium spp. (r = 0.425, p = 0.015), Anaerococcus spp. (r = 0.371, p = 0.045), Eubacterium spp. (r = 0.357, p = 0.037) for bisphenol A and Staphylococrns spp. (r = 0.392, p = 0.026), Streptococcus spp. (r = —0.486, p = 0.005) for triclosan.

Conclusion. In this study the connection of the urethral microbiota with the quality of the ejaculate and the concentration of endocrine dis-ruptors (bisphenol A and triclosan) in men semen was established. In this regard, it is necessary to take into account the role of asymptomatic urethral dysbiosis when administering patients with poor ejaculate quality.
Sınıf Öğretmenlerinin Kaynaştırmaya Yönelik Tutumlarının İncelenmesi
Authors: ÖZOKCU Osman
Published: December 2018

Bu çalışmada, sınıf öğretmenlerinin kaynaştırma
uygulamalarına yönelik tutumlarınn çeşitli değişkenler açısından anlamlı
farklılık gösterip göstermediği amaçlanmıştır. Araştırmada betimsel tarama
modeli kullanılmıştır. Araştırma grubunu Malatya ilinde ilkokullarda görev
yapan 457 sınıf öğretmeni oluşturmuştur. Araştırmada öğretmenlerin kaynaştırma
uygulamalarına yönelik tutumlarını belirlemek amacıyla Forlin, Earle, Loreman
ve Sharma tarafından (2011) yılında geliştirilen ve Bayar, Özaşkın ve Bardak
(2015) tarafından Türkçeye uyarlanan Kaynaştırmaya Yönelik Duygu, Tutum ve
Endişe Ölçeği (KYDTEÖ) kullanılmıştır. Araştırma sonuçları, sınıf
öğretmenlerinin kaynaştırma uygulamalarına yönelik tutumlarını ölçen KYDTEÖ
ölçeğinden maksimum dört puan üzerinden ortalama 2.56 puan almışlardır.
Ayrıca, öğretmenlerin kaynaştırmaya yönelik tutum ölçeği toplam puanları
arasında onların, cinsiyetleri, mezuniyet düzeylerine göre anlamlı bir
farklılık bulunmamış ancak öğretmenlerin yaşları, özel gereksinimli bireyle
etkileşim düzeyi, özel eğitim dersi alma düzeyleri ve yasa ve politikalar
hakkında bilgi düzeyi, engelli bireyle çalışma konusunda kendisine güven
düzeyi ve engelli öğrencilerle çalışma deneyimi düzeylerine göre anlamlı bir
farklılığa yol açmıştır.
Polineoplasia in patients with cervical cancer in the Chelyabinsk region of Russia
Authors: Bekhtereva S. A. , Domogirova A. S. , Vazhenin A. V. , Aksenova I. A.
Published: December 2018

The purpose of the study was to analyze the incidence of primary-multiple cancer (PMC) of the female reproductive system according to the population cancer register of the Chelyabinsk region for 15 years (1999-2013) using the example of PMC of the cervix. Carry out an analysis of the adjusted cumulative survival in the group of patients with PMC of the cervix as compared with solitary cervical cancer.

Material and methods. The material was processed using the classification of Zisman I. F. and Kirichenko G. D. (1978) on the sequence of tumors: metachronous, synchronous, mechatronic-synchronous and synchronous-metachronous. The interval of metachronousness is 6 months. The survival rates of cancer patients in the Chelyabinsk region were calculated automatically with the use of the computer program "Calculation of survival rates" — an application to the population-based cancer registry of OOO Novell-SPb. Using the method of continuous sampling, we carried out a retrospective analysis of the case histories of patients with PMC of the female reproductive system treated in the SBEO CRCOD for 15 years (1999-2013).

Results. During the period under review, 82 patients with PMC of the cervix uteri were examined, metachronous tumors prevailed in 55 (67.1%), synchronous tumors developed in 27 (33.75%). In the group of metachronous tumors in 12 (21.8%) patients had a combination of three tumors. Three (5.45%) patients had a combination of four tumors. Analysis of combinations of cervical cancer showed that more often, the cervical cancer metachronically met with breast cancer 35% (14 patients), endometrial cancer 17.5% (7 patients), ovarian cancer 7.5% (3 patients). Synchronously cervical cancer was more often combined with breast cancer 42.8% (9 patients), endometrium 28.6% (6 patients), ovaries 23.8% (5 patients) and rectal cancer 4.8% (1 patient).

The results of calculation of the index of the adjusted cumulative survival of the study group of the PMC of the cervix showed that in the group of metachronous tumors, survival rates were significantly higher than in the group of synchronous tumors: single-year survival was 84.8 ± 6.3% against 82.4 ± 9.2, three-year survival — 66.8 ± 7.8% against 47, 1 ± 12.1, and five years after the diagnosis, 53.8 ± 8.6% of patients survived.

Conclusion. Thus, patients with cervical cancer are at risk of developing cancer of other localizations that share common etiopathogenetic factors, such as HPV infection in women, hormonal disorders.
A case of long-term disease control in a patient with disseminated melanoma with synchronous detection of multiple brain metastases
Authors: Kurzhupov M. I.
Published: December 2018

The article presents clinical trials data of melanoma with brain metastasis and a clinical case of long-term survival of a patient with disseminated skin melanoma and synchronous multiple metastatic brain damage by controlling a tumor disease using modern antitumor treatment, including targeted therapy, immunotherapy, radiation therapy, radiosurgery and neurosurgery (at the stage of diagnosis). The total duration of life after detection of the disease is 22 months, with an expected 2-3 months.
Prediction of success in assisted reproductive technology with the help of morphology of the testis
Authors: Kulchenko N. G.
Published: December 2018

In the structure of infertile marriage male factor of infertility occurs in about 40-50%. About 30% of infertile men who have sought medical care have oligozoospermia or azoospermia of unknown etiology. The question of the chances of spermatogenesis recovery and increased probability of sperm extraction in repeated assisted reproductive technology (ART) programs is important for both the doctor and the patient.

Purpose. To evaluate the morphological changes of spermatogenic epithelium in patients with male infertility in terms of prognosis of ART success.

Patients and methods. 264 men with infertility were examined. The scope of clinical study of all patients included: history, examination, determination of blood hormones, study of ejaculate, karyotype, ultrasound. We performed a biopsy of the testis according to the patient's symptoms. Testicular tissue was subjected to morphological examination.

Results. Primary infertility was observed in 172 men (65.2%), secondary — 92 (34.8%). 112 (42.4%) patients had severe infertility. The results of morphological studies in these men showed a different degree of violation of spermatogenesis. Based on the study, a diagnostic algorithm of patients with male infertility is proposed, which allows to predict the success of ART taking into account morphological changes in the testicle.

Conclusion. On the basis of clinical and morphological study of the features of spermatogenesis of a particular patient a plan can be made for further personal diagnostic and therapeutic measures.
Blunt trauma of the scrotum and testicle: algorithm of choice of treatment tactics
Authors: Yarovoy S. K. , Khromov R. A.
Published: December 2018

Purpose of the study. The aim of this study is to improve the quality of emergency urological care for patients with scrotal and testicular trauma.

Patients and methods. The study is a comparison of the results of prospective (according to the algorithm) and retrospective fragments, including a total of 459 patients (414 retrospectively, 45 prospectively). Patients received inpatient urological care for traumatic damage to the scrotum and testicle in D. Pletnyov City Clinical Hospital Department of Health of Moscow, N. Lopatkin Scientific Research Institute of Urology and Interventional Radiology — Branch of the National Medical Radiology Research Centre of the Ministry of Health of the Russian Federation for the period 2008-2018.

Results. The article analyzes the clinical effectiveness of the developed algorithm for the choice of therapeutic tactics in different variants of scrotal and testicular injuries. The key differences between the proposed algorithm and the generally accepted tactics are the extension of indications for emergency testicular revision (to operate with hematocele of any volume) and the same type of antibacterial prevention/therapy of infectious posttraumatic orchitis, regardless of the nature of the injury.

Conclusion. When using the algorithm, the following clinical advantages were noted: reducing the likelihood of acute post-traumatic orchitis 2.4 times (p = 0,0271); reduced likelihood of postoperative infectious-inflammatory complications is reduced 2.0 times; reducing the likelihood of orchiectomy or hardening of the testicle 1.4 times.
Out of the office and into the field: Exploring neuropsychological correlates between search behavior and a traditional desktop task in children and adolescents with ADHD
Authors: Francisco Rosetti Marcos ,   Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad de México, México.,   Unidad de Psicopatología y Desarrollo, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Ciudad de México, México., Ulloa Rosa Elena , Palacios-Cruz Lino , Hudson Robyn , de la Peña Francisco ,   Hospital Psiquiátrico Infantil Juan N. Navarro, Ciudad de México, México.
Published: December 2018

Introduction. Cognitive assessment of patients with attention deficit hyperactivity disorder (ADHD) can help clinicians provide individually tailored treatment and advice, and researchers to identify potential associations between psychopathology and specific cognitive deficits. Assessment instruments, however, have received some criticism regarding their ecological validity, that is, the capacity to extrapolate from the performance on such tasks to aspects of everyday functioning. In order to meet this challenge we developed the Ball Search Field Task (BSFT) that takes place outdoors and uses large, open areas. In the BSFT, the goal is to search for target objects hidden under opaque containers, with experimenters assessing the efficiency of participants’ strategies to collect a maximum of these. Objective. Here we explore how the measures produced by one of the latest versions of this task (the patchy BSFT) match up with a traditional desktop task often used in clinical environments, the Tower of London (ToLo). Method. We applied the BSFT and ToLo to children and adolescents with ADHD and compared the metrics using Spearman correlations. Results. We found significant, moderate correlations between instruments, as exemplified by that of balls collected per cones lifted (BSFT) and number of moves (ToLo) (r = -.44). Discussion and conclusion. Matching correlates between the BSFT and ToLo suggest these tasks may be tapping into similar cognitive processes. The addition of assessment tools with ecological validity may help provide a more comprehensive evaluation and a better understanding of the day-to-day impact of cognitive afflictions underlying psychiatric disorders such as ADHD.
Fen Bilimleri Öğretimi Öz Yeterlik Ölçeği: Geçerlik ve Güvenirlik Çalışması
Authors: GÖZÜM Ali İbrahim Can , GÜNEŞ Tohit
Published: December 2018

Bu çalışmanın
amacı, fen öğretimi veya fen etkinlikleri yapılan ortamlardaki öğretmenlerin öz
yeterlik inanç düzeyini çeşitli değişkenlerle ölçme işlemi yapabilmek için bir
ölçme aracı geliştirmektir. Araştırmanın çalışma grubunu 2013-2014 yılları
arasında Kars il ve ilçe merkezinde görev yapmakta olan okul öncesi, sınıf ve
fen bilgisi öğretmenleri oluşturmaktadır. 
Bu araştırma tarama modeline uygun ölçek geliştirme çalışmasıdır. Ölçme
aracının geliştirilmesi için uygun olan süreç sistematik olarak izlenmiştir.
Araştırmada elde edilen veriler uygun istatistiksel yöntemler kullanılarak
analiz edilmiştir. Ölçeğin kapsam geçerliğini tespit etmek için ilgili alan
yazın taranmış ve uzman görüşüne başvurulmuştur. Yapı geçerliği için açımlayıcı
faktör analizi (AFA) ve doğrulayıcı faktör analizi kullanılmıştır. Açımlayıcı
faktör analizi, Kars il merkezinde 90 okul öncesi, 188 sınıf ve 60 fen bilgisi
olmak üzere toplam 338 öğretmenin oluşturduğu çalışma grubuna uygulanmıştır.
Açımlayıcı faktör analizi yapılan ölçeğin 46 maddeden ve iki boyuttan oluştuğu
tespit edilmiştir. Bu boyutların ve ölçeğin geçerliliğin doğrulanması için doğrulayıcı
faktör analizi yapılmıştır. Doğrulayıcı faktör analizi, Kars ilçe merkezindeki
42 okul öncesi, 153 sınıf öğretmeni ve 55 fen bilgisi olmak üzere toplam 250
öğretmene uygulanmıştır. Yapılan geçerlilik çalışmaları sonucunda iki faktörlü
yapı olumlu öz yeterlik ve olumsuz öz yeterlik şeklinde adlandırılmıştır. Ölçeğin
güvenirlik çalışması için iç tutarlık katsayısı, madde toplam korelasyonu,
ayırt edicilik ve faktörler arasında anlamlı bir ilişki bulunup bulunmadığını
tespit etmek amacıyla pearson momentler çarpımı korelasyonu hesaplanmıştır. Ölçeğe
ait Cronbach alfa güvenirlik katsayısı ,946 iken olumlu öz yeterlik boyutu
katsayısının ,933 ve olumsuz öz yeterlik alt boyutuna ait katsayının ,920 olduğu
tespit edilmiştir. Bu bulgular ışığında ölçeğin, fen öğretimi ya da fen
etkinlikleri yapılan ortamlardaki bireylere ait öz yeterlik inancını geçerli ve
güvenilir şekilde ölçtüğü belirlenmiştir.
Bilinçli Farkındalık ve Algılanan Stres İlişkisinde Ruminasyon ve Olumsuz Duygu Düzenlemenin Aracı Rolü
Authors: Cenkseven Önder Fulya , Utkan Çağrı
Published: December 2018

Araştırmada
üniversite öğrencilerinin bilinçli farkındalıkları ile algıladıkları stres
arasındaki ilişkide ruminasyon ve olumsuz duygudurum düzenlemenin aracılık rolünü
incelemek amaçlanmıştır.  Araştırma 425’i
kadın (%57) ve 320’si erkek (%43) olmak üzere toplam 745 üniversite öğrencisi
üzerinde gerçekleştirilmiştir. Öğrencilerin yaş ortalaması 21.64’dür (Ss=2.77).
Araştırmada “Bilinçli Farkındalık Ölçeği”, “Algılanan Stres Ölçeği”, “Ruminatif
Düşünme Biçimi Ölçeği” ve “Olumsuz Duygudurum Düzenlemesi Ölçeği”
kullanılmıştır. Aracılık analizlerinde regresyon temelli aracılık makrosu
kullanılmıştır. Dolaylı etkilerin anlamlılığını incelemek için hem Sobel Z, hem
de bootstrapping prosedürü kullanılmıştır. Araştırma sonucunda Sobel Z testi ve
bootstrapping sonuçları hem ruminasyonun (Z= -6.99, p<.001, Bootstrap
katsayısı= -.06, Sh= .01, %95 GA= -.09, -04) hem de olumsuz duygudurum
düzenlemenin (Z= -6.99, p<.001, Bootstrap katsayısı= -.09, Sh= .01, %95 GA=
-.12, -07) bilinçli farkındalık ve algılanan stres arasındaki ilişkide kısmi
aracı role sahip olduğunu göstermiştir.
Makale Giriş Bölümlerinin Sözbilimsel Yapılarının İncelenmesi
Authors: ÇOCUK Halil Erdem , ARI Bülent
Published: December 2018

Sözbilimsel
incelemelerin odağında hareket ve adım kavramları bulunmaktadır. Alanyazında
hareket, tutarlı bir iletişimsel işlevi gerçekleştiren sözbilimsel birim olarak
tanımlanır ve hareketin biçimsel değil, işlevsel bir birim olduğunu belirtilir.
Adım ise hareketteki bilgiyi yapılandırmak için kullanılan oluşturucu ögeler
veya yerlerdir. Bu çalışmada, 2005 ve 2015 yıllarında yayınlanan
Eğitim bilimleri alanlarındaki makalelerin giriş bölümlerindeki sözbilimsel
yapıların; makalelerin bilimsel alanlarına, yayınlandığı yıllara ve dergilere
göre anlamlı bir
farklılık olup olmadığı araştırılmıştır. Çalışma, farklı alanlardaki akademik
metinlerin sözbilimsel yapı çözümlerinin ortaya konması ve bu yapıların
istatistiksel olarak test edilmesi bağlamında önemlidir. Betimsel tarama
modelinin kullanıldığı çalışmada, ULAKBİM Dergi Park Sistemi veri tabanında; 2005-2015
yıllarında yayınlanan; başlığında “eğitim” kelimesi yer alan, dergilerin ilk ve
son sayılarındaki ilk üç eğitim içerikli Türkçe makaleler incelenmiştir. Veri
toplama aracı olarak Bilimsel Makalelerin Giriş Bölümlerindeki Hareket ve Adımları
Değerlendirme Rubriği kullanılmıştır. Rubrikten elde edilen verilere göre veri
analizinde betimsel, parametrik ve parametrik olmayan istatistikler
kullanılarak bulgulara ulaşılmıştır ve bu bulgular çerçevesinde yorumlar
yapılmıştır. Çalışmada incelenen makalelerde alanlara (Eğitim-Fen/Matematik ve
Sosyal Bilimler), yıllara (2005 ve 2015) ve yayınlandığı dergilere göre
istatistiksel farklar olduğu saptanmıştır.
Okul Yöneticilerinin Örgütsel Bağlılıkları ile Tükenmişlik Düzeyleri Arasındaki İlişkinin İncelenmesi
Authors: AKSANAKLU Pınar , İNANDI Yusuf
Published: December 2018

Bu araştırmada okul
yöneticilerinin örgütsel bağlılıklarının, onların tükenmişlik düzeyleriyle
ilişkisini ve yordama düzeyini belirlemek amaçlanmıştır. Araştırmanın çalışma
grubunu Mersin ili merkez ilçelerinde (Akdeniz, Toroslar, Yenişehir ve Mezitli)
kamu ortaokulunda görev yapan 284 Okul yöneticisi oluşturmaktadır. İlişkisel
tarama modelinde olan araştırmada, veriler 'Maslach Tükenmişlik Envanteri'
(MTE) ve 'Örgütsel Bağlılık Ölçeği'
(ÖBÖ) ile toplanmıştır. Araştırmanın sonuçlarına göre okul
yöneticilerinin örgütsel bağlılık düzeylerinin genel olarak yüksek olduğu
görülmüştür. En çok tercih edilen devam bağlılığı olmaktadır. Cinsiyet
değişkenlerine göre, örgütsel bağlılık düzeyleri incelendiğinde okul
yöneticilerinin görüşleri arasında erkek yöneticiler lehine anlamlı bir
farklılığın olduğu görülmektedir. Hem okul müdürleri hem de müdür yardımcıları
benzer örgütsel bağlılık yaşamaktadırlar. Kıdemleri ne olursa olsun yöneticilerin
bağlılık düzeyleri de birbirlerine benzer çıkmıştır. Okul yöneticilerinin yaş
değişkenlerine göre örgütsel bağlılıklarına ilişkin görüşleri arasında anlamlı
bir farklılık yoktur. Yöneticilerin tükenmişlik alt boyutlarından duygusal
tükenme ve duyarsızlaşma alt boyutlarında az da olsa tükenme yaşadıkları fakat
kritik bir durumda olmadıkları anlaşılmaktadır. Erkek yöneticilerin kendilerini
kadın yöneticilere göre daha başarılı gördükleri anlaşılmaktadır. Kıdemleri ne
olursa olsun yöneticilerin tükenmişlik düzeyleri birbirlerine benzer çıkmıştır.
Elde edilen bulgular tükenmişlik boyutlarının açıklanmasında örgütsel
bağlılığın önemli etkilerinin olduğunu ortaya çıkarmıştır. Örgütsel bağlılık
alt boyutlarından duygusal bağlılık boyutu ile tükenmişlik alt boyutlarından
duygusal tükenme ve duyarsızlaşma arasında negatif yönde anlamlı bir ilişki
bulunmaktadır. Örgütsel bağlılık alt boyutlarından duygusal bağlılık boyutu ile
tükenmişlik alt boyutlarından kişisel başarı arasında pozitif yönde anlamlı bir
ilişki bulunmaktadır. Örgütsel bağlılık alt boyutlarından devam bağlılığı boyutu
ile tükenmişlik alt boyutlarından duygusal tükenme ve duyarsızlaşma arasında
negatif yönde anlamlı bir ilişki görülürken kişisel başarı arasında pozitif
yönde anlamlı bir ilişki bulunmaktadır. Okul yöneticilerinin devam bağlılıkları
arttıkça duygusal tükenme ve duyarsızlaşma düzeyleri azalırken kişisel
başarıları da artmaktadır. Örgütsel bağlılık alt boyutlarından normatif
bağlılık boyutu ile tükenmişlik alt boyutlarından duygusal tükenme arasında
negatif yönde anlamlı bir ilişki bulunurken normatif bağlılığın duyarsızlaşma
ve kişisel başarı ile anlamlı bir ilişkisi yoktur.
Okulların Fiziksel Donanım Yeterliliğinin Müzik, Beden ve Doğa Zekâ Alanları Açısından İncelenmesi
Authors: HOTAMAN Davut
Published: December 2018

Okul,
öğrenme kuramlarındaki değişimlere göre kendini geliştirmek ve yenilemek
zorundadır. Bazı toplumlarda okula ve akademik bilgiye ilişkin tutumlar, gün
geçtikçe olumsuz bir hal almakta, bakımsız, sevimsiz, okul mimarisi yetersiz,
gerekli fiziksel donanımdan yoksun okullarda uzun ve sıkıcı bir öğrenme
sürecinin gerekliliği tartışma konusu olmaktadır. Bu durumun bir problem olarak
ele alınarak, okula karşı oluşan bu olumsuz tutumları ortadan kaldırarak okulun
gerekliliğini yeniden inşa etmek gerekmektedir. Okul bunu yaparken, gelişen
öğrenme kuramlarına paralel olarak kendisini gözden geçirerek, geliştirmek
zorundadır. Bu araştırma, nitel boyutlu bir durum çalışması
desenindedir. Bu araştırmada amaç, devlet okullarının sahip olduğu fiziksel donanımı, müzik, beden ve doğa zekâ
alanları açısından incelenmektir. Okulun
fiziksel donanımına ilişkin bilgiler yarı yapılandırılmış görüşme formu
kullanarak yönetici, yönetici yardımcılarından ve öğretmenlerden, Müzik, Beden ve Doğa Zekâ alanlarına
ilişkin kazanımlar ise, MEB Talim Terbiye Kurul Başkanlığının yeni öğretim
program kaynakları taranmak suretiyle elde edilmiştir. Araştırma yapılan İstanbul ili Esenler ve Güngören
ilçelerindeki yönetici görüşleri okulların Müzik,
Beden ve Doğa Zekâ alanlarını destekler nitelikte bir fiziksel donanıma
sahip olmadığı şeklinde oluşurken, öğretmen görüşleri de var olan fiziksel
donanımın ilgili zekâ alanlarına ait kazanımları etkili bir şekilde hayata
geçirmede yetersiz kaldığı yönünde oluşmuştur.
BITCOIN: IS IT AN ALTERNATIVE FOR THE STOCK EXCHANGES? A COMPARATIVE PANEL DATA ANALYSIS FOR THE FAR EAST ASIAN COUNTRIES AND TURKEY UNDER THE CROSS-SECTIONAL DEPENDENCE
Authors: ÇIKRIKÇI Mustafa , ÖZYEŞİL Mustafa
Published: December 2018

In this study, we investigated whether bitcoin crypto money is an
alternative to the stock exchange as an investment tool. For this purpose, the
relationship between bitcoin and the stock market was examined in terms of the
returns and liquidity. In the analysis, daily returns of the 9 Far East
countries and Turkey's stock markets and daily returns of the bitcoin were used
for the period of 22.02.2012-15.08.2018. According to the results of the model,
an increase of the Bitcoin's returns has reduced the return on the stock market
in Turkey and Far East countries. From point of this, it can be seen that the
as an investment tool, bitcoin cryptocurrency has been becoming the substitute
for the country stock exchanges included in the sample. The highest impact of
bitcoin on the stock exchange was observed in Turkey and Indonesia while the
least effect was seen on the Malaysia, Singapore and Korea respectively.
TEKDÜZEN MUHASEBE SİSTEMİNDE GERÇEKLİĞİ BOZAN HÜKÜMLER VE GÜNCELLEME İHTİYACI
Authors: DİNÇ Engin , ATABAY Esra
Published: December 2018

Türkiye’de 26 yıldır yürürlükte olan
Tekdüzen Muhasebe Sistemi, muhasebe uygulama ve eğitimine birçok katkılar
sunmuştur. Ancak, mevcut tekdüzen muhasebe sisteminin gerçeğe uygunluk
açısından birçok eksiği mevcuttur.  Bu da
muhasebe aracılığı ile üretilen finansal bilginin gerçeklikten uzaklaşmasına
neden olmaktadır. Bilginin çok değerli olduğu günümüzde, işletmelerin ihtiyaç
duyduğu gerçekçi bilginin üretilebilmesi için tekdüzen muhasebe sisteminin
yeniden güncellenmesi ve çağa uygun hale getirilmesi gerekmektedir. Bu
çalışmanın amacı; muhasebenin gerçeğe uygun bilgi üretmesinin önünde engel
olarak duran tekdüzen muhasebe sistemindeki hükümleri temel kavramlar, mali
tablo sunum ve içeriği, hesap planı ve değerleme hükümleri açısından incelemek ve
uygulamadaki yanlışlıkları tartışmaya açmaktır.
Is ACOS an independent nosology? Clinical signs and diagnosis of ACOS
Authors: Fedoseev G. B. , Trofimov V. I. , Negrutsa K. V. , Timchik V. G. , Golubeva V. I. , Aleksandrin V. A. , Razumovskaya T. S. , Rabik Yu. D. , Kryakunov K. N.
Published: December 2018

The aim of this study was to analyze inflammation features and possible causes of asthma-COPD overlap syndrome (ACOS). Methods. Clinical examination was performed for all patients included in the study. Blood levels of alpha-1-antitripsin (AAT), immunoglobulin (Ig) G and E antibodies against four bacterial antigens (Streptococcus pneumoniae, Haemophilus influenzae, Neisseria perflava, and Staphylococcus aureus), and lung function were measured in all the patients. Results. The study involved 175 patients including 78 patients with bronchial asthma, 39 patients with ACOS, 38 patients with COPD, and 20 healthy individuals. AAT blood level was reversely related to lung function and to increased IgG-antibody levels against bacterial antigens. Conclusion. Due to this fact, the authors suppose that the ACOS should be considered as an independent nosology distinct from asthma and COPD, and related to microbial inflammation and AAT level.
Comparison of clinical outcomes of sitagliptin+metformin combination and glimepiride in the management of uncomplicated type 2 diabetics
Authors: Tahashildar Jarinabanu , Singh Ravi Shekhar , Tahashildar Jameela
Published: December 2018

Background: To evaluate the comparison of clinical outcomes of sitagliptin +metformin and glimepride in uncomplicated Type-2 diabetics.Methods: This one year (July 2016 to August 2017) prospective, open label, observational clinical cohort study was carried out on type-2 diabetics. In this study 299 Type-2 diabetics patients were enrolled and were randomly allocated to two groups viz Group A and Group B. Group A received sitaglitin+metformin (50+500) mg/day and Group B received glimepride 1mg/day respectively. The follow up started after 10 days of stabilization of the patient and data recorded on 10th day was considered Zero month data and follow up continued up to Six month in each group. Comparison of FPG, PPG and HbA1c was evaluated between zero and six months within group and at six month between groups. Adverse events were recorded and summarized by treatment group.Results: At the end of six months follow up the patients of Group A who received sitaglitin+metformin (50+500) mg/day had greater reduction in FPG, PPG and HbA1c (all P<0.001) was recorded when compared between zero and six month within group. A significant reduction in FPG, PPG and HbA1c (all P<0.01) also recorded in Group B who received glimepride 1mg/day when compared between zero and six months within group. A statically significant difference (all P<0.05) was recorded at six months between group. The adverse events like hypoglycemic episodes, gastrointestinal adverse events etc were greater in Group B than Group A. Changes in weight also noted in both Groups. Weight loss in Group A and weight gain in Group B was recorded.Conclusions: The present study suggests that a significant difference may be existing in the clinical outcome interm of glycemia control and adverse events between sitagliptin+metformin combination and glimepride in type-2 diabetic patients.
Study of adverse drug reaction and causality assessment of antidiabetic drugs
Authors: M. Shanthi , C. Madhavrao
Published: December 2018

Background: Study about adverse drug reaction of antidiabetic drugs helps in ensuring maximum benefits of drug therapy.Methods: An observational study was carried out in patients attending tertiary care hospital in Kanyakumari district from August 2013 to August 2014. Adverse drug reactions due to the use of antidiabetic drugs were collected and adverse effects experienced by the patient was assessed using WHO scale, Naranjo scale, Schumock and Thornton scale and Hartwig and Siegel scale.Results: In this prospective study a total of 76 adverse events (41 male and 35 female) were identified. Most frequently observed adverse effect were hypoglycaemia and the less observed were pruritis. Maximum of 14 adverse effect were observed due to use of insulin. Combination of sulphonylurea and biguanides caused 28 adverse effects. Assessment of adverse effect using WHO scale showed 64% as probable, 16% possible, 7% conditional, 5% unclassifiable, 4% certain, and 4% unlikely. Relationship of adverse reaction to antidiabetic drugs using Naranjo scale showed 92% possibly, 5% probably and 3% as definite. Antidiabetic drug adverse effects were not preventable in 63%, definitely preventable in 19% and probably preventable in 18% as per modified Schumock and Thornton scale. Severity assessment of adverse effects were mild in 75%, moderate in 25% and no severe reactions according to modified Hartwig and Siegel scale.Conclusions: Adverse effect most commonly encountered during the study period were predictable, definitely preventable and without serious effects. Majority of the reactions were due to combination of antidiabetic drugs.
Assessment of drug attitude, medication adherence and quality of life among psychiatric patients in South Indian population: a cross sectional study
Authors: Ganesan Suganya , Selvaraj Nitya , Dass Vinoth Krishna , Jayabalan Nalinidevi , Rajamohammad Meher Ali , Anandan Isshwariya
Published: December 2018

Background: In spite of many progresses in treatment of psychiatric disorders, medication nonadherence plays an important role in worsening of clinical condition and affects quality of life among psychiatric patients. There are numerous factors contributing for medication nonadherence among patients with mental illness. So, this study was conducted to assess psychiatric patients’ adherence of medication and to improve their quality of life with psychiatric disorder. The objectives of the study were to analyze impact of pharmacophilia and pharmacophobia on medication adherence among patients with psychiatric disorders at a tertiary care hospital and to assess quality of life among pharmacophilic and pharmacophobic patients.Methods: A cross-sectional study was conducted in outpatient psychiatric department for a period of two months. After obtaining informed voluntary consent, patient’s socio-demographic details, diagnosis, and treatment were recorded from prescription slip. Patients above 18yr age with psychiatric diagnosis as per International Classification of Diseases 10 (ICD-10) and receiving at least one psychotropic medication for >1 month were enrolled in study and assessed using: Drug attitude inventory classification (DAI-10); Medication Rating Scale (MARS); Quality of life enjoyment and satisfaction Questionnaire-Short Form (Q-LES-Q-SF).Results: Among 130 patients, 116 were pharmacophilic and 14 were pharmacophobic as per DAI-10 scale. 81.9% of pharmacophilic were adherent to prescribed medication assessed using MARS scale only 14.3% were pharmacophobic. The quality of life was better in pharmacophilic compared to pharmacophobic group (p=0.002) using Q-LES-Q-SF.Conclusions: This study concluded that pharmacophilic patients have higher adherence and good quality of life index compared to pharmacophobic. Proper counselling of pharmacophobic patients by psychiatrists could improve adherence and QOL.
KAP on antibiotic usage and resistance among second professional medical students
Authors: Khajuria Kanika , Kaur Sharminder , Sadiq Shamiya , Khajuria Vijay
Published: December 2018

Background: Antibiotics are wonder drugs as they prevent and treat bacterial infections. However, their irrational use even by wrong prescribing behaviour of physician leads to antibiotic resistance medical students are future doctors and are provided knowledge and practice of antibiotics in treatment, and prevention of diseases in their study curriculum of second professional course mainly in chapters of pharmacology and microbiology. Therefore, the present study was to determine the second-year medical students’ knowledge, attitude and perception regarding antimicrobial use and resistance.Methods: Study was conducted on second professional undergraduate medical students from Government Medical College, Jammu. 140 students participated, and informed consent was taken prior to study. A validated questionnaire comprised of 20 questions was provided to them and responses were recorded. Questionnaire was comprised of 20 questions (13 questions attributed to knowledge of antibiotics usage and resistance, six to attitude and one question regarding perception).Results: The students showed fair knowledge about antibiotics and resistance. Percentages of fully correct answers was between 63-100% regarding knowledge of antibiotics. The attitude results revealed that self-medication by the student was observed in 67%, while 70% agreed that they had left over antibiotics at home, but only 42% committed that they take these left over antibiotics. As far as practice was concerned the maximum students consult text books as source of knowledge regarding resistance followed by Wikipedia.Conclusions: The current study observed high score of knowledge than attitude in medical students regarding antibiotic usage and resistance and increasing influence of internet like Wikipedia. This underscores the need for more effort in updating the students regarding antibiotic usage and resistance and laying more emphasis in the core curriculum of their academics.
Drug utilization pattern of antimicrobials use in upper respiratory tract infection in paediatric patient of rural tertiary care hospital
Authors: Gajbhiye Varsha P. , Y. R. Lamture
Published: December 2018

Background: Antimicrobial agents (AMAs) are most commonly prescribed drugs for lower respiratory tract infection (LRTI). This study was conducted to evaluate pattern of prescription and AMAs use in paediatric patient for LRTI in wards of rural tertiary care teaching hospital.Methods: This is prospective, observational study undertaken in paediatric patient in tertiary care hospital. Prescriptions of 60 patient of age group 1-12years diagnosed with LRTI admitted in paediatric ward of rural tertiary care teaching hospital were studied. Positive blood sample were studied for common microorganisms, their sensitivity and resistance to AMAs.Results: Out of 60 patients admitted in paediatric ward of LRTI, 12 patients were of mild to moderate pneumonia, three patients were of bronchiolitis, ten patients were of croups, three patients were of bronchitis and 37 patients were of severe pneumonia. The most frequently prescribed AMAs were combination of cephalosporin and aminoglycosides. The most common organism isolated was streptococcus pneumoniae sensitive to vancomycin in 92.3% and meropenem in 84.6%, resistant to ampicillin, amoxicillin and cloxacillin in 92.3% of cases.Conclusions: The study shows utilisation pattern of AMAs in LRTI, prescribing on which future intervention studies may be based to promote rational drug use.
Computer assisted learning module in experimental pharmacology for medical students: introduction and evaluation
Authors: Singh Sunita , . Harshwarshan , Singh Vivek , Gupta Barakha
Published: December 2018

Background: Animal experiments have been restricted due to strict Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA) rules and regulations for animal procurement and experimentation. At present, teaching is done by showing cards with tracings. This helps in the development of cognitive domain only. There is a need to change the traditional passive learning methodologies to an active technology based experimental learning methodology. Present educational interventional study is aimed at enhancing learning and making teaching interactive and interesting by introducing Computer Assisted Learning (CAL). Objectives of the study are to assess and evaluate the learning outcome of two methods (teaching by showing cards and computer assisted) in experimental Pharmacology and to assess the perception of students and faculty towards implementation of CAL.Methods: The study was conducted at Sarawathi Institute of Medical Sciences, Hapur, UP, India. A departmental meeting was organized to sensitize the faculty members. Test and feedback questionnaire were prepared. Participants were divided into two groups. One group was taught by cards and another by CAL. For second experiment students cross over was done. Students were assessed by post-test analysis. Feedback from the faculty and students were taken and analyzed.Results: There was improvement in knowledge of students as shown from results of post-test analysis. More than 86% of the faculty members and 80% of the students rated CAL methodology more than 3 at Likert scale.Conclusions: As compared to teaching by cards, the learning was enhanced by CAL. Students found CAL more enjoyable, interactive, comprehensible and easy to retain. In future, students would prefer CAL as an alternative method of learning in experimental laboratory.
A study on the prescription pattern of antifungal drugs in the Dermatology Department of a tertiary care teaching hospital in Southern Kerala
Authors: Gopimohan Parvathy , J. Sudha M. , Pillai Rathish T. , T. Ramani P.
Published: December 2018

Background: Skin disorders form 2% of total Out Patient Department consultations worldwide. But no such data is available from India. Studying prescription pattern is a component of medical audit that help prescribers to provide rational and cost-effective medical care. This study is about the prescription pattern of antifungals in this institution and will help in developing local policies for appropriate use of antifungal drugs. The objective was to study the prescription pattern of antifungals in dermatological diseases.Methods: This is a retrospective study conducted from 1st June 2017 to 30th November 2017 in Dermatology Department. Prescriptions included all newly diagnosed patients with cutaneous fungal infection of both sex who attended Dermatology OPD. Factors considered were sociodemographic parameters, number of patients with combination and monotherapy, number of single topical agents and Fixed Dose Combination (FDC) details of prescribing indicators.Results: 1500 prescriptions were analysed; 500 prescriptions were of fungal infection. 40.2% of the patients were in 18-35 years age group. There were a greater number of males (59.6%) than females (40.4%).Conclusions: The most common oral antifungal used was fluconazole. Terbinafine and clotrimazole were the most commonly used topical agents.
Awareness about diabetes mellitus and DKA among medical students: an observational study
Authors: G. Manu , M. Narasimhamurthy K.
Published: December 2018

Background: Diabetes Mellitus (DM) is a global epidemic and a leading cause for increased mortality and morbidity. The prevalence of Diabetes is very high so the management of DM and its complication like diabetic ketoacidosis (DKA) is very crucial in today’s world. Medical students being the future pillars of our health care system were included in this study to know their knowledge towards diabetes and its acute complication DKA.Methods: This study was a questionnaire based observational study conducted in Adichunchanagiri Institute of Medical Sciences, B G Nagara. Final year medical students and interns were included in the study.Results: A total of 150 (75 from each group) questionnaires were collected and analysed. Most of the final year students and interns were aware about the classical symptoms of diabetes (73.33% and 84% respectively) and were aware about the endocrine gland related to diabetes (82.6% and 94.6% respectively) however there were differences about the meaning of PPBS among both the groups. Interns (76%) had better knowledge regarding the fluid replacement in the management of DKA in compared to final year students (41.33%). There was statistically significant difference in knowledge between the two groups regarding GDM.Conclusions: This study identifies that both final year students and interns need to improve the practical knowledge towards diagnostic parameters of DM and treatment of DKA. Continous medical education programmes and workshops should be organised to enhance the knowledge towards DM and its complications.
Drug utilization study of bronchial asthma in adults at rural hospital
Authors: Puranik Ameya , Totade Sangita
Published: December 2018

Background: Asthma is rather a clinical syndrome than a disease with availability wide range of medications. Drug utilization studies are necessary to improve prescribing pattern among physicians.Methods: The 250 study subjects were interviewed, and prescription data was recorded in a pre-designed case record form. The data was compiled using Microsoft excel and presented in a tabulated and graphical presentation.Results: Out of 250 study subjects most of the study subjects are between 61-70 years of age. Majority of subjects are males (58%). Out of 250, (49%) are found out to be smokers. Dust, smoke and pollen are found out to be most common allergen. Most common type of asthma was mild intermittent (134) study subjects. Socio-economic status of was found out to be lower middle class in majority (158 out of 250). Large number of study population is suffering from co-morbid conditions such as URTI and COPD. Salbutamol was most common single drug used for nebulization therapy and most common combination is salbutamol + ipatropium bromide + budesonide. Most common oral drug used are methylxanthines and most frequently used intravenous drugs are deriphylline and hydrocortisone. Various antibiotics are prescribed to majority of subjects, most common was amoxicillin + clavulanic acid combination. Most commonly suffered adverse drug reaction between study subjects were gastrointestinal disturbances.Conclusions: It is concluded that prescribing pattern for asthma at A.V.B.R.H. is not according to standard guidelines, hence it is need of the hour to encourage physicians to follow guidelines.