bluuebunny/crossref_metadata_2025 huggingface dataset:
The decline of the West?
Authors: Beilharz Peter
Published: December 2018

This commentary responds to the recent enthusiasm for the idea of interregnum, revived by Gramsci in the 1930s and now by Zygmunt Bauman and Carlo Bordoni. While sympathetic to its impulse, the suggestion is made here that rather than being trapped in between, the West is entering a new authoritarian normal, where innovation as well as repetition are apparent. Trump Fever, in particular, may be a kind of smokescreen or western liberal obsession, not because the problems involved are less than fully serious, but because we allow their anxieties to disable us. Meantime, the serious global contender for global hegemony, The People’s Republic of China, is often occluded from vision. Ergo Spengler: this may be not only the epoch of the decline of the West, but also the rise of the New China.
A conceptual analysis of the term ‘populism’
Authors: Lara María Pía
Published: December 2018

In this paper I want to leave behind the failed attempts to think about populism as ideology, strategy, style, or even discourse. I will focus on the ‘conceptual battles of politics’ and their potential to influence actors to pursue and effect specific ends. Reinhart Koselleck and his ideas about conceptual history will figure prominently in my discussion, as will his concept of asymmetrical combat-concept as a means of unleashing a theoretical and political war. The goal is to demonstrate that concepts have taken the place of weapons of war among political actors.
Why ‘populism(s)’?
Authors: Casanueva Baptista Alonso , Urribarri Raul A. Sanchez
Published: December 2018

The state of debates around the topic of `populism' has made clear the difficulties that exist to provide a coherent definition of the concept. There is much to be argued from historical, epistemological, comparative and sociological perspectives that may provide clarity to the uses of the term. As the world meets new scenarios of uncommon styles of doing politics and the themes of ideological polarization and social segregation take hold, the question about the value of `populism' as a theoretical tool needs to be met with an affirmative stance that delineates its principal characteristics. The present text introduces the reader to four new perspectives that serve such a purpose and locates them among the relevant contemporary literature.
An Exploration of the Link Between Masculinity and Endorsement of IPV Myths in American Men
Authors: Gage Alida Novarese , Lease Suzanne H.
Published: December 2018

Current research has established a connection between men’s endorsement of traditional masculinity ideology and their perpetration of intimate partner violence (IPV) toward women. However, research has not yet identified the cognitive and affective pathways that link the endorsement of masculinity ideology and men’s beliefs about IPV. The current study examined men’s fear of intimacy, ambivalent (i.e., hostile and benevolent) sexism, and relationship dominance as potential mediating factors of the relationship between endorsement of traditional masculinity ideology and the acceptance of myths about male-to-female IPV in a community sample of 101 American men. Results supported the hypothesized relationship between men’s endorsement of traditional masculinity ideology and their support of myths minimizing the impact of male-to-female IPV or shifting the perceived responsibility for the offenses from the male perpetrators to the female victims. Multiple regression analyses indicated that while men’s hostile sexism and a preference for dominance in relationships did partially mediate the proposed relationship, fear of intimacy did not. The sample was largely homogeneous in terms of race/ethnicity, socioeconomic status, and educational background, although heterogeneous in age. Implications for prevention of IPV include the importance of addressing and challenging the pervasiveness of societal support of IPV myths. Clinical implications include the need for male-centric therapeutic interventions that respect male viewpoints, struggles, and strengths, and that work with, rather than against, a client’s sense of masculinity.
Toxicity and genotoxicity induced by abacavir antiretroviral medication alone or in combination with zidovudine and/or lamivudine in Drosophila melanogaster
Authors: Chen-Chen L , de Jesus Silva Carvalho C , de Moraes Filho AV , Véras JH , Cardoso CG , Bailão EFLC , Spanó MA , Cunha KS
Published: December 2018

Abacavir (ABC), zidovudine (AZT), and lamivudine (3TC) are nucleoside analog reverse transcriptase inhibitors (NRTIs) widely used as combination-based antiretroviral therapy against human immunodeficiency virus. Despite effective viral suppression using NRTI combinations, genotoxic potential of NRTIs can be increased when administered in combination. This study investigated the toxic and genotoxic potential of ABC when administered alone or in combination with AZT and/or 3TC using the somatic mutation and recombination test in Drosophila melanogaster. This test simultaneously evaluated two events related to carcinogenic potential: mutation and somatic recombination. The results indicated that ABC was responsible for toxicity when administered alone or in combination with AZT and/or 3TC. In addition, all treatment combinations increased frequencies of mutation and somatic recombination. The combination of AZT/3TC showed the lowest genotoxic activity compared to all combinations with ABC. Therefore, our results indicated that ABC was responsible for a significant portion of genotoxic activity of these combinations. Somatic recombination was the main genetic event observed, ranging from 83.7% to 97.7%.
The Diagnostic Utility of p16 Immunostaining in Differentiating Cancer and HSIL from LSIL and Benign in Cervical Cells
Authors: Wu Ming-Zhe , Wang Shiyu , Zheng Min , Tian Li-Xiang , Wu Xin , Guo Ke-Jun , Zhang YI , Wu Guang-Ping
Published: December 2018

Cervical liquid-based cytology plays an important role in the diagnosis of cervical squamous intraepithelial lesion (SIL). However, cytological evaluation alone has a relatively low sensitive. To overcome this problem, HPV DNA testing or HPV DNA combined with cytology has been applied. HPV DNA testing significantly improved the sensitivity, but the specificity is low, especially in cancer and high-grade SIL (HSIL) cases. The aim of this study was to evaluate the diagnostic utility of p16 overexpression in cervical cells of patients with HSIL and cancer. The expression of p16 was detected by immunostaining in liquid-based cells from cervical brushing in 278 patients which including: Cancer ( n = 13), HSIL ( n = 112), low-grade SIL (LSIL) ( n = 45), and Benign ( n = 108). The expression levels of p16 were significantly higher in the cancer and HSIL groups when compared with the LSIL and Benign groups ( P < 0.01). The accurate diagnostic rates of cancer and HSIL were significantly increased by p16 immunostaining plus cytology than that by cytology alone ( P < 0.01). The false negative or false positive of p16 immunostaining occurred with a unicellular pattern. With sensitivity of 96.0% and accuracy of 91.7%, the diagnostic performance of p16 immunostaining was much better than that of cytology alone with sensitivity of 36.0% and accuracy of 70.9% ( P < 0.01). p16 immunostaining in cervical brushing cells may not only be used as an ancillary tool to cytological diagnosis of cervical neoplasia but also help to distinguish HSIL from LSIL and the triage of transient infection.
The Efficacy of Near-Infrared Spectroscopy Monitoring in Carotid Endarterectomy: A Prospective, Single-Center, Observational Study
Authors: Wang Yu , Li Li , Wang Tianlong , Zhao Lei , Feng Hua , Wang Qian , Fan Long , Feng Xuexin , Xiao Wei , Feng Kunpeng
Published: December 2018

There has been no gold standard for intraoperative monitoring in carotid endarterectomy (CEA) till now. The purpose of the current study was to investigate the value of near-infrared spectroscopy (NIRS) monitoring in CEA and explore the thresholds for intraoperative cerebral hypoperfusion. Eighty-four consecutive patients who underwent CEA surgery in Xuan Wu Hospital of Capital Medical University from August 2015 to June 2016 were enrolled in this study. All patients were intraoperatively monitored by transcranial Doppler ultrasonography (TCD) and NIRS. Regional oxygen saturation (rSO2) monitored by NIRS and blood flow velocity of the middle cerebral artery (V-MCA) monitored by TCD were continuously recorded. Correlation analysis was conducted for NIRS and TCD monitoring values. Intraoperative shunting was performed in five patients according to the TCD monitoring results and surgeon preference. During clamping of the carotid artery, the Pearson correlation index between rSO2 and V-MCA was 0.581 (P<0.001). A cut-off of 12.3% decrease of rSO2 was identified as the optimal threshold for intraoperative hypoperfusion indicated by TCD monitoring, when the sensitivity and specificity were 64.3% and 90.0%, respectively, with a 0.570 Kappa value. Physical examination immediately after operation showed no ischemic injury occurred, and no death and stroke occurred during the postoperative hospitalization. Our study demonstrated that NIRS could serve as a favorable monitoring tool during CEA. A 12.3% decrease of rSO2 could be adopted as a reliable threshold for intraoperative cerebral hypoperfusion.
Surgical Versus Medical Team Assignment and Secondary Palliative Care Services for Patients Dying in a Cardiac Hospital
Authors: Gandesbery Benjamin , Dobbie Krista , Joyce Emer , Hoeksema Laura , Perez Protto Silvia , Gorodeski Eiran Z.
Published: December 2018

Background:

Secondary palliative care (SPC) provides several benefits for patients with cardiovascular disease, but historically, it has been underutilized in this population. Prior research suggests a low rate of SPC consultation by surgical teams in general, but little is known about how surgical teams utilize SPC in the setting of severe cardiovascular disease.

Aim:

To determine if surgical team assignment affects the probability of SPC for inpatients dying of cardiovascular disease.

Design:

Retrospective, cohort study.

Methods:

We identified all inpatients at a large cardiac hospital who had anticipated death under the care of a cardiology, cardiac surgery, or vascular surgery team in 2016. Our primary outcome was referral to SPC, including palliative medicine consultation or inpatient hospice care. Informed by univariate analysis, we created a multivariable logistic regression model, the significance of which was assessed with the Wald test.

Results:

Two hundred thirty-seven patients were included in our analysis: 93 (39%) received SPC and 144 (61%) were “missed opportunities.” Secondary palliative care was less frequent in patients assigned to a surgical, versus medical, team (11% vs 47%, P < .001). On multivariate analysis, surgical versus medical team assignment was the strongest risk-adjusted predictor of SPC (odds ratio [OR]: 0.10, P < .001). Other predictors of SPC included do not resuscitate status on admission (OR: 14, P < .001), length of stay (OR = 1.05/day, P < .001), and having Medicare (OR = 3.9, P = .002).

Conclusions:

Primary inpatient care by a surgical team had a strong inverse relationship with SPC. This suggests a possible cultural barrier within surgical disciplines to SPC.
“I Was There With Her”: Experiences of Mothers of Women With Breast Cancer
Authors: Ginter Amanda C. , Radina M. Elise
Published: December 2018

The purpose of this qualitative study was to examine the experiences of mothers of breast cancer patients. The theory of health-related family quality of life informed data collection and data analysis. Thirty women were interviewed about their perceptions of family quality of life following their daughters’ diagnoses. Themes included historical perspectives on cancer, familial role changes, determining how to best support daughters, mothers’ support systems, mothers’ coping mechanisms, and positive outcomes of daughters’ breast cancer. Mothers also discussed the challenge of reconciling how different family members reacted to their relatives’ diagnoses, treatment, and prognoses. Implications for research and practice are discussed.
Computerized Cognitive Training for ADHD as an Add-On Treatment to Stimulants: A Randomized Clinical Trial
Authors: de Oliveira Rosa Virginia , Moreira-Maia Carlos Renato , Wagner Flávia , Simioni André , de Fraga Bassotto Caroline , Moritz Guilherme R. , Schmitz Marcelo , Rohde Luis Augusto Paim
Published: December 2018

Objective: Computerized cognitive training (CCT) as add-on treatment to stimulants for ADHD core symptoms is scarcely investigated. The purpose of this study is to assess the effect of CCT in a randomized controlled clinical trial for ADHD in children and adolescents treated with stimulants. Method: Fifty-three participants aged 6 to 13 years receiving stimulant treatment and presenting ADHD residual symptoms were randomized either to a CCT ( n = 29) or to a controlled nonactive condition ( n = 24) for four sessions/week during 12 weeks. The main outcome measure was inattentive symptoms assessed using the Swanson, Nolan, and Pelham–IV (SNAP-IV) Scale. Secondary outcomes include, among others, hyperactive/impulsive symptoms and cognitive tests. Results: There were neither significant group differences on ADHD-inattentive symptoms after the intervention nor on both ADHD-hyperactivity/impulsivity symptoms and cognitive measures. Conclusion: Our study does not provide evidence for the benefits of cognitive training over nonactive training on core ADHD symptoms in medicated ADHD children and adolescents.
Poly and Tricky Dick: The drug war origins of the term “polydrug use”
Authors: Klein Axel
Published: December 2018

Polydrug use is presented as a particular drug-use phenomenon when the combination of substances is and always has been the practice. The origin of the term is found in the early years of the war on drugs under the Nixon administration in the US, when it was used to justify the intensification of repressive measures against drug users and to counter the growing accommodation and normalisation of cannabis. Only by presenting cannabis as the first step towards the use of harder drugs could the repression of this largely innocuous and widely used substance be justified. Drug users were presented as “polydrug users”, which offered an explanation of problematic use as rooted in the drug user, the addict, who would switch substances in accordance with availability and price. Having become established for political reasons, the term has become entrenched because it resonates and vividly describes social practice. Yet it does not add to understanding of social reality but occludes and confuses because it presents “polydrug” as a particular and peculiar pattern of consumption and not as the norm.
Playing the visibility game: How digital influencers and algorithms negotiate influence on Instagram
Authors: Cotter Kelley
Published: December 2018

Algorithms are said to affect social realities, often in unseen ways. This article explores conscious, instrumental interactions with algorithms, as a window into the complexities and extent of algorithmic power. Through a thematic analysis of online discussions among Instagram influencers, I observed that influencers’ pursuit of influence resembles a game constructed around “rules” encoded in algorithms. Within the “visibility game,” influencers’ interpretations of Instagram’s algorithmic architecture—and the “game” more broadly—act as a lens through which to view and mechanize the rules of the game. Illustrating this point, this article describes two prominent interpretations, which combine information influencers glean about Instagram’s algorithms with preexisting discourses within influencer communities on authenticity and entrepreneurship. This article shows how directing inquiries toward the visibility game makes present the interdependency between users, algorithms, and platform owners and demonstrates how algorithms structure, but do not unilaterally determine user behavior.
Modes of participation
Authors: Pina-Cabral João de
Published: December 2018

This paper focuses on the notion of ‘participation’ as it has been used in the social sciences throughout the 20th century. It proposes that there are two main traditions of use – an ‘individual’ one, and a ‘dividual’ one – and it argues in favour of the latter. It does this by examining how Simmel and Goffman, on the one hand, and Lévy-Bruhl and Durkheim, on the other, defined participation. Developed by Lucien Lévy-Bruhl in the first part of the last century, ‘participation’ in the dividual sense is today being given new life by sociocultural anthropologists such as Marshall Sahlins and phenomenologically inclined cognitive scientists such as Shaun Gallagher. The paper addresses the roots of the concept in Scholastic theology and proposes to show how central it can come to be to a sociocultural anthropology that is willing to take on frontally the challenges presently being posed by embodied cognition.
Identification of lipids of the stratum corneum by high performance thin layer chromatography and mass spectrometry
Authors: Jamin Emilien L , Jacques Carine , Jourdes Laëtitia , Tabet Jean-Claude , Borotra Nathalie , Bessou-Touya Sandrine , Debrauwer Laurent , Duplan Hélène
Published: December 2018

The stratum corneum, the outermost layer of the epidermis, is the most important skin barrier against exogenous physical and chemical effects, in addition to protecting against dehydration. Ceramides are integral parts of the intercellular lipid lamellae of the stratum corneum and play an important role in the barrier function of mammalian skin. Ceramides are sphingolipids consisting of sphingoid bases linked to fatty acids by an amide bond. Typical sphingoid bases in the skin are composed of dihydrosphingosine, sphingosine, phytosphingosine, and 6-hydroxysphingosine, and the fatty acid acyl chains are composed of non-hydroxy fatty acid, α-hydroxy fatty acid, ω-hydroxy fatty acid, and esterified ω-hydroxy fatty acid. Analytical methods, such as gas chromatography/mass spectrometry, high performance thin layer chromatography with UV detection, and liquid chromatography/mass spectrometry, have been developed for the identification and quantification of ceramides in the stratum corneum. However, only a few publications relate to the mass fragmentation patterns specific to ceramide types to determine the structure of skin ceramides. Moreover, these studies provide very limited structural information and only for some ceramides. Therefore, the aim of our study was to develop a quick and easy method of quantification of ceramides, cholesterol, and free fatty acids by high performance thin layer chromatography with ultraviolet detection. High performance thin layer chromatography with ultraviolet detection was also coupled with mass spectrometry using negative ionization by electrospray and tandem mass spectrometry (MS/MS) for identification of ceramides’ structure.
Researching and marketing to consumption collectives
Authors: Hawkins Matthew A
Published: December 2018

Consumer researchers have identified a handful of consumption collectives, such as consumption tribes, brand communities, and communities of practice. A consumption collective is a group of consumers who share consumption characteristics. Despite the use of participant screens in other research domains, published consumption collective research rarely reports on participant screens demonstrating their participants are actual members of the specific collective under investigation. Without participant screens researchers may mistakenly attribute conflicts over heterogeneous resources to intra-collective competition when the source may be inter-collective competition. This research demonstrates that consumer researchers can implement a short survey during field interviews as a participant screen. The article concludes by suggesting that marketing strategies and branding messages should be adjusted according to the individual consumer’s consumption collective membership status.
Modeling the effect of quota sampling on online fieldwork efficiency: An analysis of the connection between uncertainty and sample usage
Authors: Ochoa Carlos , Porcar Josep Miquel
Published: December 2018

Market, Opinion and Social Research is increasingly relying on non-probabilistic online panels as data sources and quota sampling as the default sampling method. Quota sampling applied to online panels requires discarding participants to ensure that the final sample match the target population distribution. This article analyzes how different features of a quota sample (such as the sample size, number, and types of quotas) impact the number of participants that must be discarded during the data collection (fieldwork efficiency). Both analytical models and simulation have been used for this purpose. Finally, we show how uncertainty about participants relates to fieldwork efficiency, providing practical recommendations in pursuing this goal.
Effect of cardiac rehabilitation on 24-month all-cause hospital readmissions: A prospective cohort study
Authors: Thomas Emma , Lotfaliany Mojtaba , Grace Sherry L , Oldenburg Brian , Taylor C Barr , Hare David L , Rangani WP Thanuja , Dheerasinghe DS Anoja F , Cadilhac Dominique A , O’Neil Adrienne
Published: December 2018

Background:

Ageing populations and increasing survival following acute coronary syndrome has resulted in large numbers of people living with cardiovascular disease and at high risk of hospitalizations. Rising hospital admissions have a significant financial cost to the healthcare system.

Aim:

The purpose of this study was to determine whether cardiac rehabilitation is protective against long-term hospital readmission (frequency and length) following acute coronary syndrome.

Methods:

Data from 416 Australian patients with acute coronary syndrome enrolled in the Anxiety Depression and heart rate Variability in cardiac patients: Evaluating the impact of Negative emotions on functioning after Twenty four months (ADVENT) prospective cohort study between January 2013–June 2014 was analyzed secondarily. Participants self-reported cardiac rehabilitation attendance over the 12 months post-discharge. All-cause readmission data were extracted from hospital records 24 months post-index event. The association between cardiac rehabilitation and all-cause readmission, frequency of readmissions, and length of stay was assessed using three methods (a) regression analysis, (b) propensity score matching, and (c) inverse probability treatment weighting.

Results:

Overall, 416 patients consented (53% of eligible patients), of which 414 (99.5%) survived the first 30 days post-discharge and were included in the analysis. Medical records were located for 409 participants after 24 months (98% follow-up rate). In total, 267 (65%) reported attending cardiac rehabilitation; there were 392 readmissions by 239 patients. Cardiac rehabilitation attendance was not associated with all-cause hospital readmission; however, it was associated with lower frequency of hospital admissions (odds ratio 0.53, 95% confidence interval: 0.31–0.91 p-value:0.022) and length of stay (coefficient –1.21 days, 95% confidence interval: –2.46–0.26; marginally significant p-value: 0.055) in adjusted models.

Conclusion:

This study substantiates the long-term benefits of cardiac rehabilitation on readmissions, including length of stay, which would result in lower costs to the healthcare system.
Risk Factors Associated With Reintervention After Thoracic Endovascular Aortic Repair for Descending Aortic Pathologies
Authors: Son Shin-Ah , Lee Deok Heon , Oh Tak-Hyuk , Cho Joon Yong , Lee Young Ok , Kim Young Eun , Kim Jung Won , Kim Gun-Jik
Published: December 2018

Background:

Thoracic endovascular aortic repair (TEVAR) is associated with several short-term benefits, including reduced morbidity and mortality; however, the long-term durability of TEVAR and the need for secondary aortic reintervention remain unclear. We aimed to determine the adverse outcomes, including aortic reintervention, after TEVAR for thoracic aortic aneurysms and dissection.

Methods:

Between October 2009 and July 2016, 130 patients underwent TEVAR at Kyungpook National University Hospital. We excluded 35 patients with traumatic injury and included the remaining 95 patients in our study after TEVAR. The patients included in this study were categorized into 2 groups (reintervention [R] and nonintervention [N] groups) according to the need for reintervention. The mean follow-up period for all 95 patients was 22.4 (20.6) months.

Results:

The overall actuarial survival rates were 83.7% (4.1%) and 63.6% (8.8%) at 1 and 5 years, respectively. The rates of freedom from aortic reintervention after TEVAR were 94.0% (3.5%), 72.8% (8.2%), and 48.9% (10.5%) at 2, 3, and 5 years, respectively. The independent risk factors for aortic reintervention were endoleaks after TEVAR (odds ratio [OR] 6.13, P = .017), increase in aortic size by over 5% per year (OR 20.40, P = .001), and peripheral vascular occlusive disease (PVOD; OR 13.62, P = .007). Patients with preoperative hemoptysis tended to show a greater need for aortic reintervention ( P = .059). Increase in aortic size by over 5% per year and PVOD were the primary risk factors for endoleaks (OR 3.82, P = .013 and OR 4.37, P = .021, respectively).

Conclusion:

Survival after TEVAR for thoracic aortic pathologies was satisfactory in most of the patients chosen as candidates for the procedure. However, the occurrence of endoleaks, increase in aortic size by over 5% per year, and PVOD were the primary causes of aortic reintervention.
The contributions of language control to executive functions: From the perspective of bilingual comprehension
Authors: Jiao Lu , Liu Cong , Liang Lijuan , Plummer Patrick , Perfetti Charles A , Chen Baoguo
Published: December 2018

Previous studies have suggested that bilingual production experience has beneficial effects on executive functions. In the current study, four experiments were conducted to investigate whether bilingual comprehension experience influences executive functions. In Experiments 1 and 2, Chinese–English bilinguals completed a flanker task interleaved with a language comprehension task (reading comprehension in Experiment 1 and listening comprehension in Experiment 2). There were three blocks distinguished by language context, with a Chinese (L1) block, an English (L2) block, and a mixed (L1 and L2) block. Results showed that performance in the mixed block was better on both congruent and incongruent flanker trials when compared with the L1 and L2 blocks, indicating better monitoring functions overall. In Experiments 3 and 4 (reading comprehension and listening comprehension, respectively), participants were also exposed to three language contexts (i.e., L1, L2, and mixed block) but performed a non-conflict control task that did not require any conflict resolution. The results of Experiments 3 and 4 showed similar performance under the three different language contexts. Taken together, these results indicate that language control mechanisms involved in bilingual comprehension contribute to domain-general executive control performance. The results suggest a monitoring mechanism establishes a bridge connecting executive functions and bilingual language control during comprehension.
Assessment of System Accuracy, Intermediate Measurement Precision, and Measurement Repeatability of a Blood Glucose Monitoring System Based on ISO 15197
Authors: Jendrike Nina , Baumstark Annette , Pleus Stefan , Mende Jochen , Haug Cornelia , Freckmann Guido
Published: December 2018

Background:

Analytical quality of blood glucose monitoring systems (BGMS) is an important aspect for many diabetes patients. Sufficiently high analytical quality is required for adequate diabetes therapy.

Methods:

In this study, system accuracy and measurement precision of a BGMS were assessed based on ISO 15197:2013. For system accuracy, this standard requires a specific glucose distribution and at least 95% of results obtained with the BGMS in capillary blood to fall within ±15 mg/dl or ±15% (at glucose concentrations <100 mg/dl or ≥100 mg/dl, respectively) of corresponding comparison method results, and at least 99% of results to be found within clinically acceptable consensus error grid (CEG) zones A and B. Based on ISO 15197:2013, intermediate measurement precision, using control solution, and measurement repeatability, using venous blood samples, were analyzed by calculation of standard deviations (SDs) and coefficients of variation (CV) at glucose concentrations <100 mg/dl or ≥100 mg/dl, respectively, although ISO 15197:2013 does not specify acceptance criteria.

Results:

The BGMS fulfilled system accuracy requirements with ≥99% of results within ±15 mg/dl or ±15% of the comparison method results, and 100% of results in CEG zones A and B. Intermediate measurement precision analysis showed SD ≤2.2 mg/dl and CV ≤2.3%. Analysis of measurement repeatability showed SD ≤2.1 mg/dl and CV ≤2.4%.

Conclusion:

System accuracy requirements of ISO 15197:2013 were fulfilled by the BGMS. As ISO 15197:2013 does not specify precision requirements, precision analysis results were compared with those reported for other BGMS in the literature and found to be similar.
Critical theory, authoritarianism, and the politics of lipstick from the Weimar Republic to the contemporary Middle East
Authors: Afary Janet , Friedland Roger
Published: December 2018

In 2012–13, we signed up for Facebook in seven Middle East and North Africa (MENA) countries and used Facebook advertisements to encourage young people to participate in our survey. Nearly 18,000 individuals responded. Some of the questions in our survey dealing with attitudes about women’s work and cosmetics were adopted from a survey conducted by the Frankfurt School in 1929 in Germany. The German survey had shown that a great number of men, irrespective of their political affiliation harbored highly authoritarian attitudes toward women and that one sign of authoritarianism was men’s attitude toward cosmetics and women’s employment. We wanted to know if the same was true of the contemporary MENA. Our results suggest that lipstick and makeups as well as women’s employment are not just vehicles for sexual objectification of women. In much of MENA world a married woman’s desire to work outside the house, and her pursuit of the accoutrement of beauty and sexual attractiveness, are forms of gender politics, of women’s empowerment, but also of antiauthoritarianism and liberal politics. Our results also suggest that piety among Muslims per se is not an indicator of authoritarianism and that there is a marked gender difference in authoritarianism. Women, it seems, are living a different Islam than men.
Comparative Outcomes for the Treatment of Articular Cartilage Lesions in the Ankle With a DeNovo NT Natural Tissue Graft: Open Versus Arthroscopic Treatment
Authors: Ryan Paul M. , Turner Robert C. , Anderson Claude D. , Groth Adam T.
Published: December 2018

Background:

The treatment of osteochondral lesions of the talus (OLTs) with a juvenile cartilage allograft is a relatively new procedure. Although other treatment options exist for large OLTs, the potential advantage of a particulated juvenile allograft is the ability to perform the procedure arthroscopically or through a minimal approach. No previous studies have looked at the results of an arthroscopic approach, nor have any compared an arthroscopic technique with an open approach.

Purpose:

To compare the outcomes of an arthroscopic transfer technique with the previously published open technique.

Study Design:

Cohort study; Level of evidence, 3.

Methods:

A total of 34 patients (mean age, 33 years) underwent treatment of talar cartilage lesions with a DeNovo NT Natural Tissue Graft. Of these treatments, 20 were performed arthroscopically and 14 were performed with open arthrotomy. There was no statistically significant difference between the groups with respect to age, lesion width, lesion depth, lesion length, or operative time. The mean lesion area was 107 mm2. The scores from 6 different validated outcome measures were recorded for patients in each group preoperatively and subsequently at 6 months, 1 year, 18 months, and 2 years.

Results:

Comparing outcome scores at each time point to baseline, there were no statistically significant postoperative differences found between open and arthroscopic approaches with regard to the visual analog scale (VAS) for pain ( P = .09), American Orthopaedic Foot and Ankle Society (AOFAS) ankle-hindfoot scale ( P = .17), Foot and Ankle Ability Measure (FAAM)–sports subscale ( P = .73), Short Form–12 (SF-12) physical health summary ( P = .85), SF-12 mental health summary ( P = .91), or FAAM–activities of daily living subscale ( P = .76).

Conclusion:

The treatment of talar articular cartilage lesions with a DeNovo NT Natural Tissue Graft demonstrated no significant differences in outcome at 2 years regardless of whether the graft was inserted with an arthroscopic or open technique.

Clinical Relevance:

Our analysis demonstrated no significant difference between an arthroscopic versus open approach at any time point for the first 2 years after implantation of a juvenile particulated cartilage allograft for large OLTs. With that said, both groups demonstrated improvement from baseline. These findings indicate that surgeons with different levels of comfort utilizing arthroscopic techniques can offer this treatment modality to their patients without altering their planned surgical approach. In addition, this will be particularly helpful in counseling patients for surgery when the extent of the defect will be evaluated intraoperatively. Patients can be counseled that they will likely have the same incisions regardless of whether they require debridement, microfracture, or implantation of a particulated allograft.
Non-state nations: Structure, rescaling, and the role of territorial policy communities, illustrated by the cases of Wales and Sardinia
Authors: Clifton Nick , Usai Alessia
Published: December 2018

This paper explores the role of non-state nations’ identity and agency with regard to relations with their host nation states. The particular focus here is on the means by which such regions might express their individuality. To this end, we employ a comparative case study analysis of two non-state nations with a range of differing yet in other ways similar qualities – namely Wales (UK) and Sardinia (Italy). We suggest that this is a valuable exercise, allowing as it does for the exploring of evidence ‘on the ground’ of the processes involved. The conceptual rationale for the paper is provided by new regionalism – regions as actors beyond the nation state. Following this, the idea of the ‘territorial policy community’ is presented as a point of departure, with the scope of the paper being to develop a diachronic framework for regional change. Given the focus on identity and interest articulation, the role of regional political parties is a particular subject of the empirical investigation, with non-state nations and nation states linked by opportunistic relationships based on political and electoral support. We then consider what this might mean with regard to the capacity of non-state nations to build on the past to successfully negotiate future policy-making agendas. Finally, we reflect on the limitations of the study, and consider the implications of its findings for further research agendas.
Networked authority and regionalised governance: Public transport, a hierarchy of documents and the anti-hierarchy of authorship
Authors: Paulsson Alexander , Isaksson Karolina
Published: December 2018

This paper is concerned with the authority of written documents and how these artefacts work as governance devices. Networked authority is introduced as a concept to elucidate how documents accumulate formal power in a collaborative process, where several formally independent but informally interdependent organisations together point out the direction of regional public transport planning in the form of one strategic document. Drawing upon recent research on bureaucracy, authority and documents, the paper empirically explores these connections in the context of public transport in Stockholm, Sweden. Based on this case study, authority was found to be accomplished as the written document reproduced an existing hierarchy of documents, through an anti-hierarchical process where the newly formed Regional Public Transport Authority involved several formally independent but informally interdependent organisations, and by lacking a sole author. These three features are crucial for understanding how a collaborative process erodes individuality and personal responsibility, while producing anonymous, networked authority. These results are discussed in relationship to Foucault’s notion of authorship, the author-function, which is derived from legal–institutional networks, much like networked authority. Understanding how networked authority is accomplished through a hierarchy of documents and an anti-hierarchy of authorship contributes with new knowledge on documents and how these work as governance devices in regional governance.
Black faces, black spaces: Rethinking African American underrepresentation in wildland spaces and outdoor recreation
Authors: Davis Janae
Published: December 2018

The Wilderness Act of 1964 defines wilderness as “an area where the earth and its community of life are untrammeled by man, where man himself is a visitor who does not remain”. It goes on to limit acceptable activities in designated wilderness areas to those associated with leisure, scenic viewing, education, and scientific inquiry. These precepts are the basis for federal wilderness management in national parks, national forests, national wildlife refuges, and lands administered by the Bureau of Land Management. They are derived from the interests and values held by the early environmental movement's predominantly white middle and upper class patrons, and imposed on diverse groups who may not hold the same views. This study examined how the imposition of wilderness management at Congaree National Park greatly restricted local African Americans' traditional fishing practices and how fishers made meaning of their displacement. Participants' experience of alienation is a result of their perceptions of racial discrimination in the park's preferential treatment of white visitors. This study argues that African American presence in the Great Outdoors is erased both materially and symbolically by racial bias in the Wilderness Act, a general lack of attention to black outdoor spaces, and the use of white outdoor values and pursuits as the criterion for which to assess African American outdoor ethos.
Low-dose chidamide restores immune tolerance in ITP in mice and humans
Authors: Zhao Hong-yu , Ma Ya-hui , Li Da-qi , Sun Tao , Li Li-zhen , Li Ping , Liu Xin-guang , Zhou Hai , Hou Yu , Liu Yang , Han Pan-pan , Zhao Ya-jing , Jing Fang-miao , Peng Jun , Hou Ming
Published: December 2018

Increased macrophage phagocytosis of antibody-coated platelets, as well as decreased numbers and/or impaired function of CD4+CD25+Foxp3+ regulatory T (Treg) cells, has been shown to participate in the pathogenesis of immune thrombocytopenia (ITP). Low-dose histone deacetylase inhibitors (HDACi’s) are anti-inflammatory and immunomodulatory agents that can enhance immunosuppression in graft-versus-host disease by increasing the number and function of Foxp3+ Treg cells, but it is unclear whether they have the potential to promote immune tolerance and platelet release in ITP. In this study, we performed in vitro and in vivo experiments and found that a low-dose HDACi (chidamide) alleviated thrombocytopenia in passive and active murine models of ITP. Further, low-dose HDACi’s attenuated macrophage phagocytosis of antibody-coated platelets, stimulated the production of natural Foxp3+ Treg cells, promoted the peripheral conversion of T cells into Treg cells, and restored Treg cell suppression in vivo and in vitro. Finally, we confirmed that low-dose HDACi’s could regulate CTLA4 expression in peripheral blood mononuclear cells through modulation of histone H3K27 acetylation. Low-dose HDACi treatment in ITP could be offset by blocking the effect of CTLA4. Therefore, we propose that low-dose chidamide administration has potential as a novel treatment for ITP in the clinic.
Children and Adults Tai Chi Study (CF-CATS2): a randomised controlled feasibility study comparing internet-delivered with face-to-face Tai Chi lessons in cystic fibrosis
Authors: Carr Siobhán B. , Ronan Patricia , Lorenc Ava , Mian Awais , Madge Susan L. , Robinson Nicola
Published: December 2018

Virtual healthcare is fast entering medical practice. Research into the feasibility of using it to teach treatment regimens such as exercise has not been explored. Maintaining an exercise regime can be difficult in cystic fibrosis: group classes risk potential infection, yet motivation is hard to maintain when alone. Tai Chi is a low-impact exercise and involves gentle, demanding movements. This study aimed to assess the feasibility, safety and acceptability of learning Tai Chiviaan internet-based approach and compared patient-reported outcomes.

Children and adults with cystic fibrosis were recruited to a randomised, comparative effectiveness trial. Participants learnt eight Tai Chi movements; teaching was delivered in eight lessons over 3 months: delivered eitherviathe internet or face-to-face. Assessments were at 3-monthly intervals over 9 months. Outcomes included health status, quality of life, sleep, mindfulness and instructor-led questions.

40 adults and children completed the eight sets of Tai Chi lessons. The median age was 22.8 years (range 6.1–51.5 years); 27 patients were female. The cohort comprised 26 adults (aged >16 years), six teenagers and eight children (aged <12 years). The groups were well matched. Feasibility and safety were demonstrated. Participants showed significant improvements in self-reported sleep, cough (both daytime and night-time), stomach ache and breathing. No differences in lung function, health status, quality of life, sleep or mindfulness was shown before or after completing the lessons.

Tai Chi was safe and well tolerated; it was feasible to deliver individual lessonsviathe internet, reducing concerns regarding cross-infection, and appeared to improve self-reported symptoms.
The SUMMIT ambulatory-ICU primary care model for medically and socially complex patients in an urban federally qualified health center: study design and rationale
Authors: Chan Brian , Edwards Samuel T. , Devoe Meg , Gil Richard , Mitchell Matthew , Englander Honora , Nicolaidis Christina , Kansagara Devan , Saha Somnath , Korthuis P. Todd
Published: December 2018

Background

Medically complex urban patients experiencing homelessness comprise a disproportionate number of high-cost, high-need patients. There are few studies of interventions to improve care for these populations; their social complexity makes them difficult to study and requires clinical and research collaboration. We present a protocol for a trial of the streamlined unified meaningfully managed interdisciplinary team (SUMMIT) team, an ambulatory ICU (A-ICU) intervention to improve utilization and patient experience that uses control populations to address limitations of prior research.

Methods/design

Participants are patients at a Federally Qualified Health Center in Portland, Oregon that serves patients experiencing homelessness or who have substance use disorders. Participants meet at least one of the following criteria: > 1 hospitalization over past 6 months; at least one medical co-morbidity including uncontrolled diabetes, heart failure, chronic obstructive pulmonary disease, liver disease, soft-tissue infection; and 1 mental health diagnosis or substance use disorder. We exclude patients if they have < 6 months to live, have cognitive impairment preventing consent, or are non-English speaking. Following consent and baseline assessment, we randomize participants to immediate SUMMIT intervention or wait-list control group. Participants receiving the SUMMIT intervention transfer care to a clinic-based team of physician, complex care nurse, care coordinator, social worker, and pharmacist with reduced panel size and flexible scheduling with emphasis on motivational interviewing, patient goal setting and advanced care planning. Wait-listed participants continue usual care plus engagement with community health worker intervention for 6 months prior to joining SUMMIT. The primary outcome is hospital utilization at 6 months; secondary outcomes include emergency department utilization, patient activation, and patient experience measures. We follow participants for 12 months after intervention initiation.

Discussion

The SUMMIT A-ICU is an intensive primary care intervention for high-utilizers impacted by homelessness. Use of a wait-list control design balances community and staff stakeholder needs, who felt all participants should have access to the intervention, while addressing research needs to include control populations. Design limitations include prolonged follow-up period that increases risk for attrition, and conflict between practice and research; including partner stakeholders and embedded researchers familiar with the population in study planning can mitigate these barriers.

Trial registration ClinicalTrials.gov NCT03224858, Registered 7/21/17 retrospectively registered https://clinicaltrials.gov/ct2/show/NCT03224858
IP3 receptors – lessons from analyses ex cellula
Authors: Rossi Ana M. , Taylor Colin W.
Published: December 2018

Inositol 1,4,5-trisphosphate receptors (IP3Rs) are widely expressed intracellular channels that release Ca2+ from the endoplasmic reticulum (ER). We review how studies of IP3Rs removed from their intracellular environment (‘ex cellula’), alongside similar analyses of ryanodine receptors, have contributed to understanding IP3R behaviour. Analyses of permeabilized cells have demonstrated that the ER is the major intracellular Ca2+ store, and that IP3 stimulates Ca2+ release from this store. Radioligand binding confirmed that the 4,5-phosphates of IP3 are essential for activating IP3Rs, and facilitated IP3R purification and cloning, which paved the way for structural analyses. Reconstitution of IP3Rs into lipid bilayers and patch-clamp recording from the nuclear envelope have established that IP3Rs have a large conductance and select weakly between Ca2+ and other cations. Structural analyses are now revealing how IP3 binding to the N-terminus of the tetrameric IP3R opens the pore ∼7 nm away from the IP3-binding core (IBC). Communication between the IBC and pore passes through a nexus of interleaved domains contributed by structures associated with the pore and cytosolic domains, which together contribute to a Ca2+-binding site. These structural analyses provide evidence to support the suggestion that IP3 gates IP3Rs by first stimulating Ca2+ binding, which leads to pore opening and Ca2+ release.
Indium Oxide/Carbon Nanotube/Reduced Graphene Oxide Ternary Nanocomposite with Enhanced Electrochemical Supercapacitance
Authors: Sengottaiyan Chinnasamy , Jayavel Ramasamy , Shrestha Rekha Goswami , Subramani Thiyagu , Maji Subrata , Kim Jung Ho , Hill Jonathan P , Ariga Katsuhiko , Shrestha Lok Kumar
Published: December 2018

Electrochemical supercapacitance performance of a ternary nanocomposite composed of mesoporous indium oxide (In2O3) nanocube crystals (size ∼50 nm) embedded in carbon nanotubes (CNT) and reduced graphene oxide (RGO) prepared by hydrothermal method is reported. A glassy carbon electrode modified with the In2O3/CNT/RGO nanocomposite material exhibited excellent electrochemical performance with a large specific capacitance of 1273 F g−1 at 5 mV s−1 and 948 F g−1 at 1 A g−1. The composite electrode showed excellent cyclic stability without any capacity loss after 5000 charge/discharge cycles. Furthermore, ∼75% capacitance retention was observed at high scan rate of 200 mV s−1. These results indicate that the novel mesoporous In2O3 cubes composited with π-electron rich conductive nanocarbons CNT and RGO would be useful as electrode material for advanced supercapacitors.