bluuebunny/crossref_metadata_2025 huggingface dataset:
INFLUENCE OF SOMATIC STATUS ON THE APPEARANCE OF RECURRENT APHTHOSIS STOMATITIS
Authors: Komova Alona A. , Borisova Eleonora G. , Zheleznyak Vladimir A. , Gorshunov Georgiy B. , Yagmurov Haidar O.
Published: December 2023

Recurrent aphthous stomatitis is a polyetiological inflammatory disease of the oral mucosa, characterized by the appearance of aphthous ulcers. The etiology and pathogenesis of this disease have not been finally revealed. There is an imbalance of immunity observed in patients who are suffering from recurrent aphthous stomatitis caused by the influence of certain trigger factors. The purpose is to summarize the literature data on the relationship of somatic status with the occurrence of recurrent aphthous stomatitis. The review considers the pathogenesis of recurrent aphthous stomatitis, as well as possible trigger factors: genetic predisposition, infections, somatic diseases, allergies, stress, and hypovitaminosis. An obligatory link in the pathogenesis of recurrent aphthous stomatitis is an imbalance of immunity - cellular (the production of pro-inflammatory cytokines increases, and the synthesis of anti-inflammatory heat shock proteins decreases) and humoral (an increase in the number of neutrophils and B-lymphocytes, activation of the complement system). Genetic predisposition, some somatic diseases (Behcet's disease) and viral infections (in particular, COVID-19) lead to an imbalance in the immune system. Provoke the occurrence of recurrent aphthous stomatitis infections, diseases of the gastrointestinal tract, stress and insufficiency of B vitamins and trace elements. The indirect effect of trigger circumstances is due to a decrease in the trophism of the oral mucosa, which leads to a local decrease in the number of factors of cellular and humoral immunity and to hyposalivation and a decrease in the pH of the oral fluid, which provokes the reproduction of opportunistic microflora. Based on the analyzed literature data, it can be concluded that the somatic status influences the development of recurrent aphthous stomatitis. Accordingly, patients suffering from recurrent aphthous stomatitis should be referred to a general doctor for evaluation.
INDICATORS OF OXYGEN ABSORPTION IN TESTICULAR TISSUES UNDER THE INFLUENCE OF INCORPORATION 137CS
Authors: Al Meselmani Mohanad A.
Published: December 2023

The results of assessing the effect of caesium-137 radionuclide, with a specific activity of 3300 Bq/kg, on oxygen consumption by rat testicular tissues. A significant increase in the rate of oxygen consumption was demonstrated on both endogenous and exogenous substrates. The maximum increase in tissue respiration was noted against the background of the use of glutamate as an exogenous substrate. Signs of disconnection of oxidative phosphorylation processes with the use of 2,4-dinitrophenol have been recorded, as well as inhibitory analysis confirms a decrease in the intensity of NAD-dependent oxidation Thus, the oral intake of caesium-137 into the body of rats with a specific activity of 3300 Bq / kg poses a danger to the male reproductive system.
Experimental evaluation of the application of polyethereketone in the manufacture of removable covering dentures supported on dental implants
Authors: Adamyan Generic G. , Moldovanov Igor A. , Podoprigora Anna V. , Kryuchkov Michail A. , Valynov Anton S. , Kozhevnikov Vitaliy V. , Zakharov Klim V.
Published: December 2023

Improving the technology of dental prosthetics, especially those based on dental implants, is closely related to the development and research of structural materials. The article provides data on a comparative study of the physical and mechanical properties of polyetheretherketone as a material for the manufacture of removable dentures supported by dental implants. Data on indicators of bending strength, diametric tensile strength and coefficient of friction for steel were studied. An experiment to study the retention capacity of a telescopic fixation system for removable dentures is described and the data obtained are analyzed.
The effectiveness of dental orthopedic manipulations performed by students with different lateralization of brain functions
Authors: Guskov Alexander V. , Akulina Maria V. , Osman Abbass Ch. , Dmitrieva Maria N. , Oleynikov Alexander A. , Magomadova Alina U. , Okorokov Viktor G. , Ramdani Abdelkrim
Published: December 2023

This article highlights the peculiarities of the influence of the dominant hemisphere on the effectiveness of orthopedic dental manipulations. Left-hemisphere and right-hemisphere students dissected the first molar of the lower jaw for a metal-ceramic crown with different hands. The effectiveness of the students' work was evaluated according to the criteria of time spent on preparation (A), thickness of grinding from the occlusal (B) and contact surfaces of the tooth (C), convergence angle (D), and the width of the formed ledge (E). According to the results of the study, it became known that right-hemispheric students working with the right hand showed abnormal results: the A indicator was 16.7 minutes; B - 1.6 mm; C - 1.7 mm; D - 22˚; E - 1.9 mm. The results of these students, revealed when working with the leading hand, correspond to normal parameters: indicator A - 14.5 min; B - 1.7 mm; C - 1.3 mm; D - 14˚; E - 1.2 mm. Left hemispheric students working with the right hand also showed results within the normal range: indicator A - 14.4 min; B - 1.8 mm; C - 1.3 mm; D - 12˚; E - 1.1 mm. The conducted research indicates the need to pay increased attention to the training of left-handed students and to provide this group of students with special educational equipment.
Modeling of the Hodgkin–Huxley neural oscillators dynamics using an artificial neural network
Authors:   Saratov Branch of Kotel`nikov Institute of Radiophysics and Electronics of Russian Academy of Sciences, Kuptsov Pavel , Stankevich Nataliya ,   National Research University "Higher School of Economics"
Published: December 2023

The purpose of this study — to represent a detailed description of the procedure for creating and training a neural network mapping on the example of the dynamics modeling of a neural oscillator of the Hodgkin–Huxley type; to show that the neural network mappings trained for single oscillators can be used as elements of a coupled system that simulate the behavior of coupled oscillators. Methods. Numerical method is used for solving stiff systems of ordinary differential equations. Also a procedure for training neural networks based on the method of back propagation of error is employed together with the Adam optimization algorithm, that is a modified version of the gradient descent supplied with an automatic step adjustment. Results. It is shown that the neural network mappings built according to the described procedure are able to reproduce the dynamics of single neural oscillators. Moreover, without additional training, these mappings can be used as elements of a coupled system for the dynamics modeling of coupled neural oscillator systems. Conclusion. The described neural network mapping can be considered as a new universal framework for complex dynamics modeling. In contrast to models based on series expansion (power, trigonometric), neural network mapping does not require truncating of the series. Consequently, it allows modeling processes with arbitrary order of nonlinearity, hence there are reasons to believe that in some aspects it will be more effective. The approach developed in this paper based on the neural network mapping can be considered as a sort of an alternative to the traditional numerical methods of modeling of dynamics. What makes this approach topical is the current rapid development of technologies for creating fast computing equipment that supports neural network training and operation.
Evaluation of overall survival and disease-free survival of adjuvant chemotherapy and hormone therapy in patients with breast cancer
Authors: Roudini Kamran , Mirzania Mehrzad , Emami Seyyed Amirhossein , Safayi Seyyed Reza , Yazdi Ehsan Kamali , Zarifi Nasim , Mortezazadeh Masoud , Rafiee Shima , Mofidi Abbas , Kashani Mehdi , Mansouri Ensieh sadat , Siahkal mahalleh Mohammad Rasekhi , Mehrizi Ahmad Khajeh
Published: December 2023

Background: This study evaluated the effect of adjuvant chemotherapy and hormone therapy on overall survival and disease-free survival in patients with breast cancer with hormone receptor-positive, HER2-negative tumors without lymph node involvement.
Methods: Breast cancer patients with hormone receptor-positive, HER2-negative, and no lymph node involvement were included in this retrospective cohort study. Patient records were used to collect data on sex, age, time of disease onset, tumor subtype, tumor size, grade, lymphovascular and perineural involvement, ki67, and treatment protocols. Patients were divided into 2 groups: Patients who received both adjuvant chemotherapy and hormonal therapy and patients who received hormonal therapy only. Disease-free survival index (DFS) and overall survival index (OS) were evaluated.
Results: Sixty-seven female patients were enrolled in this study. Of them, 68.2% received both adjuvant chemotherapy and hormonal therapy and 31.6% received hormonal therapy only. During follow-up, recurrences occurred in 8 patients. The 3-year and 5-year DFS were 93.4% and 90%, respectively. The 3-year and 5-year DFS was 94% and 92%, respectively, in patients who received both adjuvant chemotherapy and hormonal therapy, and 91% and 85%, respectively, in patients who received hormonal therapy. None of the factors studied affected the 3-year and 5-year DFS. The 3-year and 5-year DFS OS were 98.6% and 96.9%, respectively
Conclusion: Adjuvant chemotherapy in patients with breast cancer with hormone receptor-positive, HER2-negative, and no lymph node involvement compared with similar patients receiving hormone therapy alone had no significant difference in disease-free survival index and overall survival index.
Evaluation of Changes in miR-7113-3p, miR-6721-5p, and MAP2K1 gene expressions in tumor and normal tissues of patients with oral cancer
Authors: Mohammadi Kebria , Rafi Mahshid , Mohammadpour Hadiseh , Jamshidian Faranak
Published: December 2023

Background: Squamous cell carcinoma of the oral cavity (OSCC) is one of the most common cancers in the Head and Neck Squamous Cell Cancer (HNSCC) group. The increasing frequency of oral carcinomas and their late-stage appearance is a major worldwide health concern. MicroRNAs (miRNAs) play an important role in cancer growth and progression, as the available relevant data indicate. However, no information is available about the parts miR-7113-3p and miR-6721-5p taken in OSCC. In the present study, the expression of MAP2K1, miR-7113-3p, and miR-6721-5p was examined to determine their possible biological role in the advancement of oral squamous cell carcinoma.
Methods: Quantitative Real-Time PCR was applied to investigate the mRNA expression of MAP2K1, miR-7113-3p, and miR-6721-5p in fresh frozen OSCC tissues and adjacent normal fresh frozen tissues of 30 patients and then, the relationship between MAP2K1 Expression and clinical parameters was studied.
Results: MAP2K1 expression dramatically increased in tumor tissues compared to the normal tissues, while miR7113-3p and miR-6721-5p expression significantly decreased. Furthermore, a statistical correlation of p=0.04 was also observed between increased MAP2K1 expression and Perineural invasion. In addition, the downregulation of miR-7113-3p was positively correlated with the overexpression of MAP2K1 (p=0.0218), and a negative correlation was observed between the downregulation of miR-6721-5p and overexpression of MAP2K1 (p=0.7771).
Conclusion: Based on the findings, miR-7113-3p, and miR-6721-5p might be prospective biomarkers for OSCC patients and can be utilized to detect OSCC at an early stage of its diagnosis. MAP2K1 overexpression is linked to the development of OSCC and Perineural invasion.
A surgical management of melanotic prognoma tumor of Infancy – A case report
Authors: Hazare Shilpa , Hazarey Isha , Hazarey Jitendra , Bhansali Pritish , Mahant Vishal , Sadiya Rashiqua
Published: December 2023

Melanotic neuroectodermal tumors (MNTI) also known as retinal anlage tumor and melanotic progonoma is highly aggressive lesion found in children within 6 months of age. It is a relatively rare pathology and is also rare to metastasise. MNTI can be seen in various locations within the oral cavity, the most common being maxillary jaw. Presently advent technology of has enabled us to utilise various different modalities ranging from radical excision, incomplete resection to chemotherapy. Chemotherapy is preferred in cases of contraindication of surgical approaches. The results regarding each approach can be mixed, successful tumour regression or complete failure. The present article focuses on successful subtotal excision of MNTI in a one year old infant.
Health Crisis in Gaza: The Urgent Need for International Action
Authors: Beiraghdar Fatemeh , Momeni Javad , Hosseini Elham , Panahi Yunes , Negah Sajad Sahab
Published: December 2023

The current and ongoing conflict imposed in Gaza has led to severe environmental challenges in Gaza, resulting in a health crisis that demands immediate attention and intervention. A comprehensive study has evaluated the pressing mental health, water and sanitation, access to healthcare, and infectious disease challenges plaguing the region. Mental health issues, particularly among children and adolescents, have surged in the wake of the conflict, with trauma-related symptoms expected to persist. The water and sanitation crises pose severe public health hazards, with an overwhelming majority of water unfit for consumption and escalating infectious diseases. Shortages of medicines, fuel, and breakdowns have profoundly affected access to healthcare in healthcare facilities, significantly impacting women and girls. The academic society is responsible for conducting research, providing education, and training, and advocating for policy changes. At the same time, the united nation’s (UN) role is vital in providing aid, advocating for policy changes, and monitoring human rights and health situations. Urgent action is imperative to stabilize the environmental and health impacts and allow humanitarian aid into Gaza to alleviate the severe health problems. This study underlines the critical need for international support and intervention to address the multifaceted health crises in Gaza and prevent further deterioration.
Bibliometric Analysis of Published Original Research Articles on Leisure Constraints between 1991 and 2019
Authors: Köse Elif , Yerlisu-Lapa Tennur , Gökçe Hüseyin , Alexandris Kostas , Yücel Ali Serdar
Published: December 2023

Background: The decrease in the frequency and duration of participation in leisure activities has negative effects on the physical, cognitive and psychological health of individuals. In this context, identifying the obstacles, which prevent individuals from participating in leisure activities, may offer important clues to institutions and organizations in taking measures to increase participation.
Methods: The bibliometric analysis method was used in this study. The research was carried out with 306 articles scanned from the Web of Science (WoS) core database between 1991 and 2019.
Results: Studies conducted in leisure area increased systematically according to 5-year periods and mostly authors from USA, Australia and Canada produced them. The mainstream subjects, which attracted the attention of researchers during recent years, are detected to be self-efficacy, segmentation, mental health and fear related to intrapersonal constraint topics.
Conclusion: In order to cope with physical and mental health problems resulting from aging of the world population, and technological developments, and negative effects generated by inactive modern life style, priority should be given to studies on leisure constraints to be conducted on a more comprehensive basis. Another suggestion is to encourage health policies and applications which can increase participation in leisure activities.
Smoking Cessation Success and Affecting Factors in Geriatric Patients
Authors: Çetinkaya Pelin Duru , Turan Ayşe , Deniz Pelin Pinar , Çetinkaya Ferhat , Arpaz Seren , Uysal Atilla , Dülger Seyhan , Salepçi Banu , Kilinç Oğuz , Dilektaşlı Aslı Görek
Published: December 2023

Background: There are difficulties in the treatment of smoking cessation in elderly patients. However, elderly smokers who gave up smoking had lower rates of death from heart attack, stroke, and cancer, as well as improved cognitive function. This study aimed to investigate the affecting factors and the success of smoking cessation rate in patients aged 60 and over in Turkey.
Methods: Six smoking cessation outpatient clinics from four provinces were included in the study. The records of 1,065 patients who applied to a smoking cessation outpatient clinic between 2016 and 2019 and who were 60 yr of age or older were scanned. Overall, 917 cases that could be reached after treatment were included in the study. Smoking cessation rates at the first month, 3rd month, 6th month, 9th month and 12th month were given.
Results: Of the 917 cases, 65.1% were male and 34.9% were female. Smoking cessation rates were 45.6% on the first month, 39% on the third month, 35.1% on the sixth month, 31.2% on the ninth month, and 30.3% at the twelfth month. Smoking cessation success was higher in men than in women.
Conclusion: Since the success of smoking cessation in the elderly was similar to that of adults. Since smoking is an independent risk factor for death in the elderly, there should be greater willingness to provide elderly patients with smoking cessation treatment to reduce physical function loss and promote healthier aging.
ZNF692 Promotes the Progression of Colon Adenocarcinoma by Regulating HSF4 Expression
Authors: Yang Zhengpeng , Wu Hao , Dai Defu , Yuan Yufeng , Shao Xueqian
Published: December 2023

Background: Colon adenocarcinoma (COAD) is one of the most common cancer happened in gastrointestinal tract, with the overall incidence rate of 4%-5% among human beings. Like most malignancies, we uncovered the exact mechanisms of the pathogenesis of colorectal cancer yet. Therefore, there is an urgent need to explore the molecules that can be used as diagnostic maker at early stage. In addition, we also need to define the essential factors that related to the prognosis and treatment of the colon carcinoma.
Methods: The study was conducted at the Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, China in September 2020. The R language was used to identify the differentially expressed genes. We performed receiver operating characteristic curve analysis to determine the diagnostic markers for COAD. The machine learning strategy was used to assess the effectiveness of genes in the diagnosis of COAD. The molecular mechanism and prognostic value of genes were explored by bioinformatics analysis and molecular experiments.
Results: The expression level of heat shock factor 4 (HSF4) was significantly elevated in COAD patients (P=1.89×10-29), according to The Cancer Genome Atlas (TCGA) database. Additionally, survival analysis showed the higher expression level of the HSF4 was correlated with the poor prognosis in COAD.
Conclusion: The HSF4 was the target gene of zinc finger protein 692(ZNF692). HSF4 might promote the progression of COAD through the apoptosis pathway. It was diagnostic and prognosis maker of COAD. Furthermore, the upstream gene of HSF4, ZNF692, promotes the progression of colorectal cancer by regulating HSF4 expression.
Comparison of Circulating Variants during the Beginning, Middle and the End of the 4th Wave of COVID-19 in Tehran Province, Iran in 2021
Authors: Ahmadi Akram Sadat , Shafiei-Jandaghi Nazanin Zahra , Sadeghi Kaveh , Nejati Ahmad , Zadheidar Sevrin , Mokhtari-Azad Talat , Yavarian Jila
Published: December 2023

Background: Whole viral genome sequencing with next generation sequencing (NGS) technique is useful tool for determining the diversity of variants and mutations of severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2). In this study we have attempted to characterize the mutations and circulating variants of the SARS-CoV-2 genome during the 4th wave of COVID-19 pandemic in Tehran, Iran in 2021.
Methods: We performed complete genome sequencing of 15 SARS-CoV-2 detected from 15 COVID-19 patients during the 4th wave of COVID-19 pandemic with NGS. Three groups of the patients at the beginning, middle and the end of the 4th wave were compared together.
Results: We detected alpha and delta variants during the 4th wave of the pandemic. The results illustrated a dominance of amino acid substitution D614G in spike, and the most frequent mutants were N­-R203K, G204R, S235F, nsp12-P323L, nsp6-G106del, G107del and F108del.
Conclusion: The detection of the virus mutations is a useful procedure for identifying the virus behavior and its genetic evolution in order to improve the efficacy of the monitoring strategies and therapeutic measures.
Typhoid and Non-Typhoid Salmonellosis Related Mortality in Iran, National Data from the Ministry of Health
Authors: Esfandiari Negin , Farkhani Ehsan Mosa , Sharifi Laleh , Bokaie Saied
Published: December 2023

Background: Despite the declining trend, salmonellosis is still an important preventable cause of death in Iran and the world, especially in certain age and occupational subgroups, and the need for preventive measures, especially raising awareness of at-risk groups, is necessary.
Methods: Data were obtained from the Ministry of Health covering the years 2013 to 2019. The data were then stratified by year, season, month, and province of death as well as sex, age group, belonging to rural vs. urban communities and cause of death and were then analyzed using SPSS to report differences in age, sex, seasonal patterns, and spatial distribution.
Results: Non-typhoid salmonellosis (NTS) and typhoid were recorded as the cause of 800 and 32 deaths, respectively, with the highest number in 2015 and 2013. Septicemia was the cause of 87.3% of deaths due to NTS, whereas typhoid was the cause of 62.5% of its respective cases. The highest percentage of death related to both occurred in spring (P<0.001). NTS mortality rates were higher in the 70-80 and 80-90 age groups, while typhoid mortality was greatest in the under 10 yr age group. NTS mortality was higher in urban while typhoid mortality was higher in rural areas (P<0.001). Most deaths occurred in Ardabil, Sistan and Baluchistan and Khorasan Razavi provinces and Sistan and Baluchistan, West Azerbaijan and Khorasan Razavi related to NTS and typhoid, respectively.
Conclusion: Salmonella remains a preventable cause of death, especially among the elderly and children, the data gathered in this study provides important information for priority setting in specific subpopulations and food safety policy.
Identifying Factors Related to Divorce in Iranian Couples: A Case Study in Yazd, Iran
Authors: Tavakolian Nastaran , Madadizadeh Farzan , Taheri Soodejani Moslem , Lotfi Mohammad Hassan
Published: December 2023

Background: Divorce is one of the most damaging social issues. Since the divorce rates are increasing rapidly, the current study evaluated the effects of factors leading to divorce.
 Methods: In this qualitative study, by using two-stage sampling method (purposive and snowball) 4 couples on the verge of divorce visiting consulting center and 8 experts with experience in the field of family and divorce in Yazd city were selected. Semi-structured interviews were used for data collection. The contents of the interviews were transcribed verbatim and analyzed using a content analysis method.
Results: The experts who participated in this study included several marriage and divorce registrars, lawyers, and family counselors with over 10 years of experience in the field of family and divorce. The mean age of women on the verge of divorce was 33 ± 8.51 years and for men 37.2 ± 6.13 years. Fifty percent of the couples had a bachelor's degree and 62.5% of them were self-employed. Most of them had a marriage period of 5-10 years. A total of 23 codes were extracted from the interviews. The codes were organized into four main themes. Major topics included lack of preparation for marriage, psychological factors, unfavorable marital relationships, and social factors.
Conclusion: The interference of families, extramarital relationships, early marriage and the lack of communication skills and media literacy are the most influential factors of divorce.
Infectious and Non-infectious Causes of Abortion in Saanen and Alpine Goats
Authors: Esmaeili Hossein , Sharifi Majid , Gharagozloo Faramarz , Vodjgani Mahdi , Hamedi Mona
Published: December 2023

Background: Infectious and non-infectious abortions are necessary to be evaluated in Saanen and Alpine breeds as they have been recently imported to Iran whith out enough information about their susceptibility to diseases in the country situation. The present study aimed to investigate the causes of abortion in Saanen and Alpine to compare their susceptibility to each identified abortion factor.
Methods: A total of 600 Saanen and 600 Alpine breeds were studied. Abomasal contents of foeti and serum samples from aborted does were analyzed by PCR and conventional culture methods and beta-hydroxy butyrate was measured in the serum of aborted animals.
Results: Among 1200 pregnant goats, 59 Saanens and 80 Alpines aborted their fetus. Escherichia coli was isolated from 4 Saanens and 3 Alpines. Trueperella pyogenes was isolated from 5 Saanens and 7 Alpines. Pregnancy toxemia was the cause of abortion in 12 Saanens and 30 Alpines which showed a significant difference between the two breeds. Six Saanens and 10 Alpines aborted their fetus following trauma.
Conclusion: As abortion is an economically important issue, especially for the breeds which we have less information about, the susceptibility of animals and the frequency of each abortifacient should be evaluated.
Ethical considerations in sarcopenia research
Authors: Shafiee Gita , Balajam Narges Zargar , Heshmat Ramin , Larijani Bagher
Published: December 2023

The Article Abstract is not available.
Evaluation of Serum Annexin A1 Values in Patients with Inflammatory Bowel Diseases
Authors: KÜÇÜK İrfan , YAZGAN Yusuf , YILDIRIM İdris , AKBAŞ ŞİMŞEK Tuğba , ÇAKIR GÜNEY Başak , SALMANOĞLU Musa , KAPLAN Mustafa
Published: December 2023

Objective: Annexin A1(AnxA1) is an anti-inflammatory mediator. In the current study,we aimed to evaluate whether or not serum Annexin A1 levels of inflammatory boweldiseases (IBDs) patients relate to the clinical and laboratory traits of IBDs.

Methods: This case-control study included 67 ulcerative colitis (UC) patients (47 males and 20 females), 53 Crohn’s disease (CD) patients (37 males and 16 females) and 60 healthy controls (36 males and 24 females). The Mayo Clinical scoring system (MCS) was used for UC and the histological activity index (HAI) was determined by Truelove and Richards method. The Crohn's disease activity index (CDAI) was used for CD patients. Montreal classification was used for the localization of IBDs.

Results: The mean serum AnxA1 concentrations were not statistically significant in UC, CD and the control groups (26.36±17.30 ng/ml vs 22.98±12.74 vs 24.45±12.18 ng/ml respectively, p=0.404). The MCS, HAI of UC patients negatively correlated with the serum AnxA1 values (rho=-0.616, p
Factors Affecting Student Satisfaction With The Quality of Training Services of The University of Economics, Vietnam National University, Hanoi (VNU)
Authors: Thi Hue Le , Thi Linh Chi Nguyen , Thi Hao Phi
Published: December 2023

This article studies the factors affecting the level of student satisfaction with the quality of training services at the University of Economics, VNU. The authors used the survey method through questionnaires, collected primary data and included it in a multivariate regression model for analysis and evaluation. Research results show that there are five factors that affect student satisfaction including: Lecturers, facilities, training programs, non-academic factors, and reputation. Among these factors, reputation is the factor that has the strongest impact on student satisfaction, followed by the group of lecturer factors, non-academic factors and training programs, and the remaining impact is facilities. at least. The authors propose a number of solutions to improve the quality of university training.
Agroecología y enseñanza de las ciencias naturales: una relación a considerar en la escuela rural
Authors: Norato Quevedo Nancy Paola , Hernández Barbosa Rubinsten
Published: December 2023

A agroecologia, como campo de aplicação multidisciplinar, está fundamentada teórica e metodologicamente em várias disciplinas, mas tem como fundamento central o conhecimento tradicional, que retoma princípios ecológicos, sociais e econômicos das comunidades para favorecer os agroecossistemas e suas diversas formas de regulação. Neste artigo, são descritas três perspectivas da agroecologia, produto da análise bibliométrica realizada pelos autores, e que permite vislumbrar elementos a serem considerados no ensino de ciências naturais, especialmente de escolas do campo, a fim de sugerir algumas possibilidades investigativas, pedagógico e didático para sua abordagem. A agroecologia abre novas opções de estudo e pesquisa na escola do campo, como centro de convergência cultural, de acordo com contextos e necessidades específicas das comunidades que promovem, entre outros, a soberania alimentar, o cuidado com o meio ambiente e a resiliência dos agroecossistemas. Concluindo, a agroecologia vem ganhando interesse global, articulando-se em processos sociais e políticas públicas em diversos países do mundo, resgatando e tornando visível a sabedoria local como meio de propor formas, entre outras coisas, de satisfazer as necessidades alimentares atuais e futuras das comunidades, onde se articulam saberes, interesses, necessidades e saberes culturais da escola do campo.
Periferias, o comum e a finitude da subsunção capitalista no ensino superior: uma resposta a Narita
Authors: Szadkowski Krystian
Published: December 2023

Neste texto, o autor oferece uma resposta à resenha de Felipe Ziotti Narita a respeito do livro Capital in Higher Education (Palgrave Macmillan, 2023). A partir de uma análise crítica do ensino superior, o trabalho aborda temas como marxismo, trabalho, subsunção, periferias, conhecimento e o comum.
DFT and Electrochemical Study of Novel Green Corrosion Inhibitor (Pyrantrin) for 1100-H14 Aluminum Corrosion Remediation in 1 M H2SO4 Acidic Environment
Authors: UGİ Benedict
Published: December 2023

The study on Corrosion Inhibition of 1100-H14 Aluminum in H2SO4 Acidic Deploying pyrantrin as a Green Inhibitor was investigated by adopting different experimental methods, including weight loss, electrochemical impedance spectroscopic, potentiodynamic polarization, and computational methods. It was observed that pyrantrin was a good inhibitor for the 1100–H14–type aluminum. Inhibition efficiency was recorded between 42.5 % and 95.2 % for aluminum at 500 ppm and 1500 ppm concentrations. This high inhibition efficiency was attributed to the strong adsorption of the molecules on both metal surfaces. Electrochemical impedance showed higher and increasing charge transfer resistance values and decreasing values for the double-layer capacitance, indicating better inhibition. From quantum calculations, the EHOMO value was higher than that of the ELUMO, while the energy gap was calculated to be 1.9 with a binding energy of 132.9, indicating stronger adsorption and inhibition.
Synthesis, Antimicrobial Evaluation, and Docking Study of Some New Isoxazoline Derivatives Derived from Chalcones
Authors: SALİM Inas , MUTANABBİ ABDULA Ahmed , MOHAMMED NOORİ JASSİM Abdulkadir
Published: December 2023

New 2-Isoxazoline derivatives containing furan moieties were synthesized from chalcones as starting materials, followed by antimicrobial activity. Chalcones were synthesized by reacting p-methoxy acetophenone or 3,4-(methylenedioxy)acetophenone with various aldehydes that were synthesized using Claisen-Schmidt condensation. Subsequently, the obtained products underwent cyclization with hydroxylamine hydrochloride to yield the corresponding 2-isoxazoline derivatives. The synthesized isoxazolines have been characterized via 1H-NMR, FTIR, and GC-Mass spectroscopy. The new derivatives were screened for their activity against different bacterial species as well as Candida albicans and exhibited moderate to excellent activity as new antimicrobial agents. A docking study was conducted on most potent derivatives against glucoseamine-6-phosphate synthase (GlcN-6-P), the target enzyme for antimicrobial agents. The study aimed to understand how the discovered derivatives interact with the binding pocket residues of the enzyme.
Satisfacción del turista usando factores motivacionales: comparación de modelos de aprendizaje estadístico
Authors: Vanegas Juan Gabriel , Muñetón Santa Guberney
Published: December 2023

El nivel de satisfacción de un turista con el destino visitado y su intención de volver a visitarlo se asumen como dependientes de su experiencia previa con el lugar. Para observar esta perspectiva relacional, se utilizó un conjunto de datos de 386 turistas que visitaron la ciudad de Mede­llín (Colombia) durante el año 2018. Para predecir la variable de volver a visitar la ciudad y la satisfacción con el destino, se usaron las variables consideradas de empuje (push) y aquellas que halan (pull) al turista. Se estimaron cuatro modelos de aprendizaje estadístico para la clasificación de los turistas: regresión logística, árboles aleatorios, máquinas de soporte vectorial y el conjunto de aumento de gradiente extremo. Las variables más importantes en las estimaciones de la satisfacción fueron ‘hablar sobre una experiencia de viaje en el futuro’ e ‘ir a lugares que mis amigos no han visitado’; y para volver a visitar la ciudad fueron ‘visitar lugares históricos’ y ‘viajar a bajos precios’.
Student Privacy and Learning Analytics
Authors: Francis Mary , Avoseh Mejai , Card Karen , Newland Lisa , Streff Kevin
Published: December 2023

This single-site case study will seek to answer the following question: how is the concept of privacy addressed in relation to a student success information system within a small, public institution of higher education? Three themes were found within the inductive coding process, which used interviews, documentation, and videos as data resources. Overall, the case study shows an institution in the early stages of implementing a commercial learning analytics system and provides suggestions for how it can be more proactive in implementing privacy considerations in developing policies and procedures.
Standardization of an isothermal test as a novel diagnostic tool in México for the molecular detection of Chlamydia abortus in small ruminants
Authors: Aragon López Carlos Eduardo , Palomares Reséndiz Erika Gabriela , Cuevas tellechea Sergio , Reyna Granados Javier Rolando , Arellano Reynoso Beatriz , Sánchez Castro Miguel Angel , Leyva Corona Jose Clemente , Morales Pablos Marcela Ivone
Published: December 2023

Ovine Enzootic Abortion (OEA) is caused by Chlamydia abortus and has recently been recognized as endemic in Mexico. Due to the impact of OEA on intensive lamb production, it is necessary to establish a sanitary control plan based on an efficient diagnosis. The loop-mediated isothermal amplification technique (LAMP) is a molecular test that can specifically identify C. abortus. The aim of this study was to standardize the LAMP technique for the specific detection of C. abortus from ovine vaginal exudate. Primers were identified and modified from an electronic database. The effective conditions of the technique were determined using synthetic DNA and positive biological samples by PCR as references. The assay detection limit was 1 × 10-5 of genetic material, equivalent to 8.5 copies. The standardized LAMP test is proposed as a novel molecular tool for the rapid and specific diagnosis of C. abortus infection from ovine vaginal exudate samples in Mexico.
Simultaneous Intratumoral Hemorrhage in Multiple Brain Metastases of Endometrioid Carcinoma: A Rare Presentation of A Rare Metastasis
Authors: BAHADIR Sinan
Published: December 2023

Metastasis of endometrioid carcinomas to the brain is rare, usually solitary, and has a poor prognosis. Intratumoral bleeding is also a poor prognostic factor for metastatic brain tumors but rarely occurs in gynecological cancers. A female patient who was under chemotherapy for endometrioid carcinoma was admitted to the emergency department for recent deterioration and seizures. She had confusion and left hemiparesis, along with an elevated systolic blood pressure and platelet count of 45,000 /mL. An emergent computerized tomography and subsequent magnetic resonance imaging revealed multiple hemorrhagic metastatic lesions in both hemispheres and cerebellum. Brain metastasis of endometrioid carcinoma is rare and can present with intratumoral hemorrhage, which is associated with a poor prognosis and is more likely to occur in the setting of low platelet counts. This case highlights the importance of monitoring brain metastasis in patients with endometrioid carcinoma and considering the possibility of intratumoral hemorrhage.
Mathematical modeling of quorum sensing dynamics in batch culture of luminescent bacterium Photobacterium phosphoreum 1889
Authors: Bartsev S. I. , Sarangova A. B.
Published: December 2023

At the beginning of the paper, the level of necessary phenomenology of complex models is discussed. When working with complex systems, which of course include living organisms and ecological systems, it is necessary to use a phenomenological description. An illustration of the phenomenological approach is given, which captures the most significant general principles or patterns of interactions; the specific values of the parameters cannot be calculated from the first principles, but are determined empirically. An appropriate interpretation is also chosen empirically and pragmatically. However, in order to simulate a wider range of situations, it becomes necessary to lower the level of phenomenology, switch to a more detailed description of the system, introducing interaction between selected elements of the system. The requirements for a system model combining ecological, metabolic and genetic levels of cell culture description are formulated. A mathematical model of quorum sensing dynamics during the growth of batch culture of luminescent bacteria at different concentrations of the nutrient substrate has been developed. The model contains four blocks describing ecological, energy, quorum and luminescent aspects of bacterial culture growth. The model demonstrated good agreement with the experimental data obtained. When analyzing the model, three oddities in the behavior of the culture were noted, which presumably can change the idea of some processes taking place during the development of a culture of luminescent bacteria. The results obtained suggest the presence of some additional control system for the luminescent reaction via the synthesis pathways of FMN · Н2 or aliphatic aldehyde. In this case, the generalized description of the contribution of energy metabolism to luminescence only through ATP is too strong a simplification. As a result of comparing the model dynamics with the experiment, a discrepancy arose between the concentration of the substrate (peptone) measured in the experiment and its effective influence on the bacterial population growth. This discrepancy seems to indicate peptone is not the leading substrate, and growth is limited by nutrients contained in the yeast extract, the concentration of which did not change in these experiments. The discrepancies noted between the expectations and the results of experimental data processing, together with the assumptions about the causes of these discrepancies, set the direction for further experimental and theoretical studies of quorum sensing mechanisms in a culture of luminescent bacteria.
A phenomenological model of non-genomic variability of luminescent bacterial cells
Authors: Bartsev S. I.
Published: December 2023

The light emitted by a luminescent bacterium serves as a unique native channel of information regarding the intracellular processes within the individual cell. In the presence of highly sensitive equipment, it is possible to obtain the distribution of bacterial culture cells by the intensity of light emission, which correlates with the amount of luciferase in the cells. When growing on rich media, the luminescence intensity of individual cells of brightly luminous strains of the luminescent bacteria Photobacterium leiognathi and Ph. phosporeum reaches 104–105 quanta/s. The signal of such intensity can be registered using sensitive photometric equipment. All experiments were carried out with bacterial clones (genetically homogeneous populations). A typical dynamics of luminous bacterial cells distributions with respect to intensity of light emission at various stages of batch culture growth in a liquid medium was obtained. To describe experimental distributions, a phenomenological model that links the light of a bacterial cell with the history of events at the molecular level was constructed. The proposed phenomenological model with a minimum number of fitting parameters (1.5) provides a satisfactory description of the complex process of formation of cell distributions by luminescence intensity at different stages of bacterial culture growth. This may be an indication that the structure of the model describes some essential processes of the real system. Since in the process of division all cells go through the stage of release of all regulatory molecules from the DNA molecule, the resulting distributions can be attributed not only to luciferase, but also to other proteins of constitutive (and not only) synthesis.
Prioritization of potential pharmacological targets for the development of anti-hepatocarcinoma drugs modulating the extrinsic apoptosis pathway: the reconstruction and analysis of associative gene networks help
Authors: Demenkov P. S. , Antropova E. A. , Adamovskaya A. V. , Mishchenko E. I. , Khlebodarova T. M. , Ivanisenko T. V. , Ivanisenko N. V. , Venzel A. S. , Lavrik I. N. , Ivanisenko V. A.
Published: December 2023

Hepatocellular carcinoma (HCC) is a common severe type of liver cancer characterized by an extremely aggressive course and low survival rates. It is known that disruptions in the regulation of apoptosis activation are some of the key features inherent in most cancer cells, which determines the pharmacological induction of apoptosis as an important strategy for cancer therapy. The computer design of chemical compounds capable of specifically regulating the external signaling pathway of apoptosis induction represents a promising approach for creating new effective ways of therapy for liver cancer and other oncological diseases. However, at present, most of the studies are devoted to pharmacological effects on the internal (mitochondrial) apoptosis pathway. In contrast, the external pathway induced via cell death receptors remains out of focus. Aberrant gene methylation, along with hepatitis C virus (HCV) infection, are important risk factors for the development of hepatocellular carcinoma. The reconstruction of gene networks describing the molecular mechanisms of interaction of aberrantly methylated genes with key participants of the extrinsic apoptosis pathway and their regulation by HCV proteins can provide important information when searching for pharmacological targets. In the present study, 13 criteria were proposed for prioritizing potential pharmacological targets for developing anti-hepatocarcinoma drugs modulating the extrinsic apoptosis pathway. The criteria are based on indicators of the structural and functional organization of reconstructed gene networks of hepatocarcinoma, the extrinsic apoptosis pathway, and regulatory pathways of virus-extrinsic apoptosis pathway interaction and aberrant gene methylation-extrinsic apoptosis pathway interaction using ANDSystem. The list of the top 100 gene targets ranked according to the prioritization rating was statistically significantly (p-value = 0.0002) enriched for known pharmacological targets approved by the FDA, indicating the correctness of the prioritization method. Among the promising potential pharmacological targets, six highly ranked genes (JUN, IL10, STAT3, MYC, TLR4, and KHDRBS1) are likely to deserve close attention.
RatDEGdb: a knowledge base of differentially expressed genes in the rat as a model object in biomedical research
Authors: Chadaeva I. V. , Filonov S. V. , Zolotareva K. A. , Khandaev B. M. , Ershov N. I. , Podkolodnyy N. L. , Kozhemyakina R. V. , Rasskazov D. A. , Bogomolov A. G. , Kondratyuk E. Yu. , Klimova N. V. , Shikhevich S. G. , Ryazanova M. A. , Fedoseeva L. A. , Redina О. Е. , Kozhevnikova О. S. , Stefanova N. A. , Kolosova N. G. , Markel A. L. , Ponomarenko M. P. , Oshchepkov Yu. D.
Published: December 2023

The animal models used in biomedical research cover virtually every human disease. RatDEGdb, a knowledge base of the differentially expressed genes (DEGs) of the rat as a model object in biomedical research is a collection of published data on gene expression in rat strains simulating arterial hypertension, age-related diseases, psychopathological conditions and other human afflictions. The current release contains information on 25,101 DEGs representing 14,320 unique rat genes that change transcription levels in 21 tissues of 10 genetic rat strains used as models of 11 human diseases based on 45 original scientific papers. RatDEGdb is novel in that, unlike any other biomedical database, it offers the manually curated annotations of DEGs in model rats with the use of independent clinical data on equal changes in the expression of homologous genes revealed in people with pathologies. The rat DEGs put in RatDEGdb were annotated with equal changes in the expression of their human homologs in affected people. In its current release, RatDEGdb contains 94,873 such annotations for 321 human genes in 836 diseases based on 959 original scientific papers found in the current PubMed. RatDEGdb may be interesting first of all to human geneticists, molecular biologists, clinical physicians, genetic advisors as well as experts in biopharmaceutics, bioinformatics and personalized genomics. RatDEGdb is publicly available at https://www.sysbio.ru/RatDEGdb.