bluuebunny/crossref_metadata_2025 huggingface dataset:
Frequency of ABO and Rh-D blood groups in cervical cancer
Authors: Saha Subarna , Khatun Ayesha , Begum Shirin Akter , Islam Md Ashadul , Sonia Farah Anjum , Hossain Fatema , Chakrabarty Tonusree
Published: January 2023

There is much evidence that the ABO blood group system may play a role in the pathogenesis of the disease. The relationship between ABO and Rhesus blood groups and cancer risk has been demonstrated in many research works. However, concerning gynaecological malignancies, these findings are inconsistent. This study aimed to evaluate the frequency of ABO and Rh-D blood groups in patients with carcinoma cervix. This cross-sectional study was conducted in the Department of Transfusion Medicine, Department of Gynaecological Oncology and Department of Pathology of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka. A total of 110 clinically suspected cervical cancer patients were included in this study. Pap smear tests was done in all cases and the patients were divided into case (Pap test positive) and control group (Pap test negative). A total of 55 patients were included in each group. Blood groups (ABO & Rh-D) of all the patients were recorded. A higher number of the patients in the cervical cancer group were multiparous than in the control group. Almost in two-thirds of the population, the age of marriage was <18 years in the cervical cancer group compared to 34.5% in the control group. More than one-third population had “O” blood group in the case group, while it was 31% in the control group. The almost equal number had Rh D+ve in the case and control (92.7% vs. 94.5%). The differences between the blood group and Rh D were not statistically significant between the two groups. Nearly half (40.0%) of the participants had used a hormonal contraceptive in the case and 61.8% in control. The differences in hormonal contraceptives use were statistically significant within the two groups. The distribution of “O” blood group and Rh D +ve cases was found to be higher in patients with cervical cancer than in non-cancer patients although the difference was not statistically significant.
BSMMU J 2022; 15(2): 70-74
Clinical evaluation of crown and bridge prosthesis placed in patients attended in the Bangabandhu Sheikh Mujib Medical University
Authors: Rahman Md Mahbubur , Abid Mohammad , Biswas Utpalendu , Akter Rozina
Published: January 2023

The proper diagnosis and clinical assessment are essential when dealing with the complications of fixed restorations in dental prosthesis. This cross-sectional study was carried out to evaluate clinically the crown and bridge prosthesis among the patients attending in the Department of Prosthodontics, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. A total of 50 patients with full veneer crowns or bridges were selected. Clinical assessment for the contour of the prosthesis, nature of the contact of the prosthesis, type of occlusal contact in ICP were done. Among the study subjects, 44% and 52% of the prostheses were over-contoured buccally and lingually, respectively. The prostheses contacted with adjacent tooth mesially at occlusal one-third in 58%, middle one-third in 40% & cervical one-third in 2% cases. The prostheses contacted with adjacent tooth distally at occlusal one-third in 52%, middle one-third in 44% & nothing abnormality detected in 4%. About half of prostheses (54%) contacted with an opposite tooth at the level of central fossa whereas 40% at buccal to central fossa and only a few numbers (6%) at lingual/palatal to central fossa. The nature of proximal contact was normal in 52%, tight in 36%, and open in 12% of the prostheses. As the prostheses cemented in the patient's mouth were not up to the accepted clinical standards, so enrichment of knowledge about prosthetics are needed and responsibilities should be ensured.
BSMMU J 2022; 15(2): 80-83
Evaluation of graft uptake in underlay myringoplasty using dry and wet temporalis fascia graft
Authors: Haque Md Hasanul , Huq AHM Zahurul , Sultana Nigar , Ahmed Tanvir , Naha Abirvab , Razzak Md Abdur , Rahman Khan Mohammad Jahidur , Sayied Md Jaber Al
Published: January 2023

Chronic otitis media (COM) is a vital cause of deafness worldwide. Myringoplasty is one of the best treatment options for COM (inactive mucosal variety). Temporalis Fascia is the most favored grafting material among various autografts, which can be used as dry or wet depending upon the Surgeon's choice. The main focus of this study is to compare the graft uptake rate by using dry and wet temporalis fascia by underlay technique. This cross-sectional comparative study was directed from January 2018 to June 2019 at the Department of Otolaryngology-Head & Neck Surgery of BSMMU, Dhaka. All consecutive cases of COM (inactive mucosal) who underwent surgery were randomly assigned either into the dry (Group-A) or wet temporalis fascia group (Group-B). At 12 weeks follow-up, the density of graft failure (4.4% vs. 8.8%) and retraction pocket (0% vs. 2.2%) were higher in the wet procedure. However anterior blunting (2.2% vs. 2.2%) were the same in both procedures, and medialization (2.2% vs. 0%) were more in the dry procedure. Air Bone Gap (ABG) improved significantly in both groups following operation but reduced in Group-A more significantly than Group-B. On the other hand, there was no remarkable difference in successful graft uptake between the groups (Dry group-91.12% vs. wet group-84.44%, p>0.05). No graft material is superior to others in terms of graft uptake.
BSMMU J 2022; 15(2): 84-89
The association of maternal serum CRP level with gestational diabetes mellitus
Authors: Haque Nadira , Nahar Khairun , Hoque Moinul , Rauniyar Neha , Aziz Tabinda Anjum , Haque Shakila , Khaleda Laila , Tithi Shaila Sharmin , Koly Homayera
Published: January 2023

Gestational diabetes mellitus is a common medical condition during pregnancy that has detrimental effects on maternal health and fetal well-being. Many serum markers are known to be associated with gestational diabetes, a subclinical inflammatory state that liberates inflammatory mediators, acute phase proteins like CRP into the maternal circulation. This phenomenon has invited many researchers to study inflammatory mediators and acute phase proteins as markers of gestational diabetes mellitus.This case-control study was conducted in the Department of Obstetrics and Gynecology of Bangabandhu Sheikh Mujib Medical Univer- sity, Dhaka, between July 2016 and June 2017. The objective of the study was to evaluate the association of serum CRP level with gestational diabetes mellitus. A total of 140 pregnant women who attended the out-patients antenatal clinic at their 2nd and 3rd trimester (13-40 weeks) of pregnancy were enlisted for the study. The case group consisted of 70 pregnant women who were diagnosed with GDM. Similar number of healthy pregnant women were recruited as control. GDM was diagnosed using standard 75 g OGTT. Blood sample was taken from study subjects to estimate the serum CRP level. CRP level up to 5mg/L was taken as normal. Data analysis was done by utilizing SPSS version 16. The mean BMI of the case group women was significantly higher than the mean BMI of the control (p=0.001). The mean CRP level in case was 13.87±10.19 and the mean for CRP for control group was 4.59±2.41. There was an association of raised level of CRP with GDM. Pregnant mothers with raised level of CRP (& gt; 5 mg/L) were 6.1 times more likely to have GDM than mothers with normal level of CRP. The study concluded that a significant association was found between the raised level of CRP and gestational diabetes mellitus.
BSMMU J 2022; 15(2): 96-101
Requirement of ESWL after ureterorenoscopy and lithotripsy in the management of upper ureteric stone: comparison between Holmium Yag laser and pneumatic lithotripsy in a referral hospital, Bangladesh
Authors: Chowdhury Md Ashif , Waheed SM Shameem , Rakib Md Abdur , Hossain Faruk
Published: January 2023

Various methods have been employed for the removal of ureteric calculi all over the world. Both Ureteroscopic Pneumatic and Laser lithotripsy are popular procedures for this purpose. However proximal migration of stone fragments are not uncommon in these procedures while treating upper ureteric stones. Extra corporeal shock wave lithotripsy (ESWL) may require to fragment those proximally migrated stones after the ureteroscopic Pneumatic or Laser lithotripsy. To compare the requirement of ESWL in the management of ureteric stone between Holmium Yag Laser and Pneumatic Lithotripsy. This study included 100 patients with upper ureteric stones who underwent ureteroscopic lithotripsy at the Department of Urology, CMH, Dhaka, between October 2010 and September 2012. Laser lithotripsy was used in 50 patients (Group A), and pneumatic lithotripsy was used in the remaining 50 patients (Group B). In each case, the same ureteroscope, video monitor, baskets, or irrigation devices were used. A kidney ureter and bladder radiograph and ultrasonograph were performed on patients one month and three months after lithotripsy. Patients with migrated fragments or insufficient clearance underwent a supplementary procedure such as ESWL. Mean age was 41.9}10.9 years and 41.3}12.3 years in Group A and Group B respectively. Males were predominant in both groups. Mean stone size was 1.36 } 0.36 cm in Group A and 1.37} 0.36 cm in Group B. Complete stone clearance was 94.0% in Group A and 76.0% in Group B. EWSL requirement rate was significantly higher in Group B (24.0%) than Group A (6.0%). Peri procedural complications like hemorrhage was significantly higher in Group B and mucosal disruption/perforation was almost same in both the groups. EWSL requirement rate was comparatively higher in pneumatic lithotripsy than laser lithotripsy.
BSMMU J 2022; 15(2): 111-114
Pattern of urinary tract and surgical site infection in allograft renal recipient during early postoperative period
Authors: Saha Bhajan Kumar , Rahman Md Habibur , Hossain Tohid Md Saiful , Hossain Faruk , Ghosh Kartic Chandra
Published: January 2023

A kidney transplant (KT) offers a significant survival benefit and is the only curative treatment for patients with ESRD. Infectious complications are still a leading cause of morbidity and death among transplant patients. This study aimed to assess the organisms and risk factors responsible for urinary tract and surgical site infection in allograft live-related renal transplant recipients during the early post-transplant period. This observational follow-up study was conducted among 20 purposively selected patients who underwent renal allograft transplant surgery from July 2019 to December 2020 in the Department of Urology, BSMMU, Dhaka. Patients with a history of renal transplant recipients or congenital renal anomalies and any urological malignancy were excluded from the study. After kidney transplant, UTI developed in 6 (30%) renal transplant recipients where all were complicated types and occurred between 10 to 14 days postoperatively. UTI was caused by E. coli in 3 (15%) patients, while Klebsiella and Enterococci were causative organisms for 1 (5%) and 2 (10.0%) patients, respectively. SSI developed in 3 (15%) renal transplant recipients where two were superficial, and one was deep. SSI occurred between 5-8 days postoperatively. SSI was caused by S. aureus in 2 (10%) patients and Pseudomonas in 1 (5%) patient. UTI was significantly more in older patients and the patients with a longer duration of catheterization. Older patients and overweight patients had significantly higher rates of SSI. In total, 33% of the recipient during the early hospital stay developed UTIs, all of which were complicated types. SSI developed in 15%, where 2/3rd was superficial and 1/3rd was deep. Older age with a longer duration of catheterization and DJ stent was found to be associated with the occurrence of UTI, while older age and high BMI were related to the event of SSI.
BSMMU J 2022; 15(2): 127-131
Niemann Pick disease: a rare lysosomal storage disease
Authors: Kundu Gopen Kumar , Anwar Sk Serjina , Liza Noor A Sabah , Alam Syeda Tabassum , Ahmed Sanjida , Sarker Mohammad Arbab , Nishi Meher Nigar , Afrin Sharmina , Quddus Mohammad Abdul
Published: January 2023

Niemann Pick Disease (NPD) is a rare autosomal recessive lysosomal storage disease characterized by lysosomal lipid storage. The disease is caused by deficiency of enzyme, acid sphingomyelinase (ASM) which leads to accumulation of sphingomyelin & other lipids in reticuloendothelial cells of various organs like liver, spleen, bone marrow, lymph node, brain, nerves and kidney. Four types of the disease have been identified i.e. A, B, C and D. We report a case of Niemann Pick Disease type C. The patient was a 2.5 years female child who presented with developmental regression, recurrent seizures, failure to thrive and hepatospleenomegaly. Bone marrow (BM) aspiration was performed which showed hypercelluler marrow with few fat laden macrophage resembling foam cell that are characteristics of this disease.
BSMMU J 2022; 15(2): 141-144
Association of gestational diabetes mellitus with vitamin D status among women attending at Bangabandhu Sheikh Mujib Medical University
Authors: Islam Fahmida , Laila Tarafdar Runa , Nahar Khairun , Das Tripti Rani , Akhter Nargis , Ahmed Sheikh Salahuddin , Khurshid
Published: January 2023

Gestational diabetes mellitus (GDM) is an important cause of maternal and perinatal morbidities. Vitamin D is associated with glucose metabolism. The present study was aimed to assess the association of maternal serum vitamin D level with GDM. This case-control study was conducted among 80 pregnant women at the Department of Obstetrics and Gynecology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka. Among the 80 patients, 40 were GDM patients (cases) and 40 pregnant women without GDM (controls). The serum vitamin D level was measured for all of them. The mean vitamin D level of the cases and controls were 18.8±5.5 ng/ ml and 22.1±7.3 ng/ml, respectively (P=0.025). There was significant difference regarding the vitamin D adequacy in between case and control groups (P= 0.006) and the respondents with vitamin D <30.0 ng/ml had 7.2 times more chances to have GDM compared to that of the respondents with vitamin D ≥30 ng/ml (OR=7.2; 95% confidence interval =1.5-35.1). There was a significant negative correlation between serum vitamin D level and plasma glucose level 2-hour after 75 gm glucose drink (r= -0.33, P= 0.004). In conclusion, serum vitamin D level was found low in patient with GDM compared to those without GDM.
BSMMU J 2022; 15(3): 162-166
Effect of Bevacizumab Treatment in Cerebral Radiation Necrosis : Investigation of Response Predictors in a Single-Center Experience
Authors: Lee Shin Heon , Choi Jung Won , Kong Doo-Sik , Seol Ho Jun , Nam Do-Hyun , Lee Jung-Il
Published: January 2023

Objective : Bevacizumab is a feasible option for treating cerebral radiation necrosis (RN). We investigated the clinical outcome of RN after treatment with bevacizumab and factors related to the initial response and the sustained effect.Methods : Clinical data of 45 patients treated for symptomatic RN between September 2019 and February 2021 were retrospectively collected. Bevacizumab (7.5 mg/kg) was administered at 3-week intervals with a maximum four-cycle schedule. Changes in the lesions magnetic resonance image (MRI) scans were examined for the response evaluation. The subgroup analysis was performed based on the initial response and the long-term maintenance of the effect.Results : Of the 45 patients, 36 patients (80.0%) showed an initial response, and eight patients (17.8%) showed delayed worsening of the corresponding lesion. The non-responders showed a significantly higher incidence of diffusion restriction on MRI than the responders (100.0% vs. 25.0%, p<0.001). The delayed worsening group showed a significantly higher proportion of glioma pathology than the maintenance group (87.5% vs. 28.6%, p=0.005). Cumulative survival rates with sustained effect were significantly higher in the groups with non-glioma pathology (p=0.019) and the absence of diffusion restriction (p<0.001). Pathology of glioma and diffusion restriction in MRI were the independent risk factors for non-response or delayed worsening after initial response.Conclusion : The initial response of RN to bevacizumab was favorable, with improvement in four-fifths of the patients. However, a certain proportion of patients showed non-responsiveness or delayed exacerbations. Bevacizumab may be more effective in treating RN in patients with non-glioma pathology and without diffusion restriction in the MRI.
ANALISIS SENTIMEN PERMENDIKBUD PENCEGAHAN DAN PENANGANAN KEKERASAN SEKSUAL DI LINGKUNGAN PERGURUAN TINGGI MENGGUNAKAN SUPPORT VECTOR MACHINE (SVM)
Authors: Saemani Reinhard Alfaries , Setiyawati Nina
Published: January 2023

Social media is no longer a foreign thing for people in today's technological era, one of the social media that is often used is Twitter. Twitter is used to communicate with other people and Twitter users can also give each other opinions on an issue. By involving 1252 Tweets, this study aimed to use the Support Vector Machine (SVM) algorithm on Tweet data. The processes carried out in this research are crawling, cleaning, translate, labeling, tokenizing, stop words, stemming, SVM classification. .The results showed that the accuracy level of using the SVM algorithm after the param grid was 80.3% using the parameter C = 10; gamma = 0.1; and kernel = rbf as a benchmark in the classification process. This shows that the classification process using the SVM algorithm is quite accurate.
PENGARUH DIAMETER VARIASI THROTTLE BODY TERHADAP DAYA, TORSI DAN EMISI GAS BUANG PADA SEPEDA MOTOR BEAT PGM-FI 110 CC TAHUN 2014
Authors: Lapisa Remon , Rahman Rizky , Yulia Basri Irma , Afnison Wanda
Published: January 2023

This study is to find out how the diameter of the throttle body is 22mm, 24mm, and 26mm. Regarding torque, power, and exhaust emissions on the Beat-PGM FI 110 cc motorcycle in 2014. This was done as an effort to improve engine performance. This study uses an experimental approach. Data retrieval directly from motorcycles which measured torque and power using a dynamometer, as well as a gas analyzer aims to test exhaust emissions resulting from testing each type of throttle body. The results of the tests carried out with variations in the diameter of the throttle body 22 mm, 24 mm, and 26 mm showed the best torque results obtained on the 24 mm throttle body, which was 7.765 N.m at 6000 rpm. This means that the torque has increased by 5.8% from the test results using a standard throttle body. The best power results obtained on a 24 mm throttle body is 6.6075 HP at 7,000 rpm. This means that the power has increased by 4.5% from the test results using a standard throttle body. The best emission results obtained on a 24 mm throttle body, namely CO decreased by an average of almost close to 50% as well as HC.Keywords: Throttle Body, Torque and Power, Exhaust Emissions, EFI
Šumarska enciklopedija (1959–63., 1980–87) i njene osobitosti
Authors: Godinić Mikulčić Vlatka
Published: January 2023

Šume su značajni čuvar prirodnih uvjeta života, izvor gospodarske vrijednosti i sirovina za drvnu industriju i mnoge druge industrijske grane. Šumarstvo je složena djelatnost koja sadržava biološku, ekološku, tehničku i ekonomsku komponentu pa se enciklopedijska obradba toga područja nameće kao imperativ. Iako je malen broj zemalja koje su pristupile izdavanju posebne šumarske enciklopedije, obiman rad Leksikografskoga zavoda (isprva Leksikografski zavod FNRJ, od 1991. Leksikografski zavod Miroslav Krleža) vrlo je brzo nakon osnutka obuhvatio šumarstvo i izdao izvorno koncipiranu Šumarsku enciklopediju (1–2. sv. u 1. izd. 1959–63. te 1–3. sv. u 2. izd. 1980–87; glavni urednici Aleksandar Ugrenović i Zvonimir Potočić), koja se može svrstati među enciklopedičke rijetkosti.Metodologija rada obuhvaćala je u prvome redu (1) pronalaženje, selektiranje i organiziranje znanstvenih informacija iz primarnih izvora. Služba arhiva Općega odjela Zavoda obavlja poslove čuvanja arhivskoga gradiva i potrebno gradivo o Šumarskoj enciklopediji bilo je dostupno, opsežno i vrlo raznoliko. U ovome je radu pokazano da pohranjeni zapisi o nastanku Šumarske enciklopedije predstavljaju brižljivo zabilježena svjedočanstva u obliku korespondencija, bilješki sa sastanaka, sačuvanih originalnih članaka itd. Metodologija je dalje uključivala (2) analizu arhivskog gradiva, proučavanje i analizu oba izdanja Šumarske enciklopedije, ali i znanstvenih radova iz drugih izvora, napose znanstvenih časopisa.Vodeći računa o cilju rada, koji je u ovome radu bio dvojak, u rezultatima se donosi osvrt na urednike struka i autore članaka te ilustracija u Šumarskoj enciklopediji (1), a potom se analizira i valorizira sadržaj i struktura oba izdanja Šumarske enciklopedije (2). Rezultati analize pokazuju da je prvo izdanje Šumarske enciklopedije odgovaralo svojim sadržajem trenutku u kojemu je stvorena, tadašnjim potrebama šumarske i drvnoindustrijske tehnologije i stručnih kadrova. U sljedeća dva desetljeća postignut je neočekivano velik napredak u nizu stručnih disciplina koje ulaze u područje interesa šumarstva i drvne industrije. Drugo izdanje Šumarske enciklopedije nastojalo je udovoljiti očekivanjima stručnjaka i javnosti koja su proizlazila iz potreba novoga doba. Trebala je poslužiti kao udžbenik i kao priručnik. Time je čitatelj dobio cjelovitu i preglednu sliku pojedinih zaokruženih sadržaja. Šumarska enciklopedija, koja je izišla u izdanju Leksikografskoga zavoda, uspjela je sažeto prikazati fundamentalna saznanja o šumarstvu svima zainteresiranima, olakšavajući donošenje stručnih odluka pri rješavanju šumarske teorijske i praktične problematike.
Elektronički rječnici u informacijsko doba
Authors: Filipović Petrović Ivana , Parizoska Jelena
Published: January 2023

Elektronička je leksikografija grana leksikografije koja se bavi teorijskim i praktičnim aspektom mrežnih rječnika, a obuhvaća enciklopedije, leksikone, glosare, terminološke repozitorije i druge informacijske alate kojima se može pristupiti putem interneta. Među obilježjima i prednostima elektroničkih rječnika iz korisničke perspektive ističe se brz pristup informacijama te novi tip informacija, poput zvučnih i slikovnih priloga u natuknici ili povezanost s drugim softverom kao što je ugrađeno poučavanje i učenje, igre i slično. Iz leksikografske perspektive naglašava se oslobođenje od abecednoga ustroja sadržaja rječnika, kao i dokidanje ograničenja linearnoga teksta uključivanjem poveznica u natuknicu i opcije pokaži manje/više kojom upravlja korisnik.Ipak, unatoč prednostima, prisutne su kritike zbog nedostatne ponude izvorno elektroničkih rječnika u leksikografijama pojedinih jezika. Stoga suvremena e-leksikografija nastoji naći rješenja za izazove proizišle iz naoko idealnih digitalnih uvjeta, poput opasnosti od preplavljivanja korisnika golemom količinom nestrukturiranih podataka u kojoj se gubi informacija, ali i odgovora na pitanje što leksikografi mogu učiniti da korisnički izbor u potrazi za informacijom budu rječnici, a ne kakve druge internetske baze podataka i brze tražilice.U radu se daje pregled suvremenih dosega elektroničke leksikografije iz teorijske i tehnološke perspektive. Najprije se donose osnovne teorijske postavke vezane uz obilježja e-rječnika i teoriju u elektroničkoj leksikografiji, koja se istovremeno naslanja na postojeću teoriju leksikografije koja počiva na lingvistici i u kojoj važnu ulogu imaju procjene leksikografa o načinima obrade unutar mikrostrukture te na nadogradnju koja uključuje tehnološke, funkcionalne i estetske aspekte izrade rječnika u digitalnom obliku. Zatim se pokazuju primjeri različitih rješenja u elektroničkim rječnicima hrvatskoga i drugih jezika koja nastoje odgovoriti na izazove informatičkoga i informacijskoga doba te pomiriti leksikografske mogućnosti i korisničke potrebe. Na temelju toga daje se zaključak o tendencijama izrade rječnika i drugih leksikografskih alata koji će pratiti ubrzani tehnološki razvoj i društvene potrebe u suvremeno doba.
OXIDATIVE MODIFICATION OF BLOOD PLASMA PROTEINS OF PATIENTS WITH PSORIASIS VULGARIS
Authors:   SE «Institute of Dermatology and Venerеology of NAMS of Ukraine», Semko G. O. , Sokol O. A. ,   SE «Institute of Dermatology and Venerеology of NAMS of Ukraine», Kondakova H. K.
Published: January 2023

The aim is to study the state of indicators of oxidative modification of proteins in the blood plasma of patients with psoriasis vulgaris. Materials and Methods. 18 patients with psoriasis vulgaris (average age – 44.4 years) and a group of healthy donors – 22 persons, who made up the control group – were examined. Oxidative modification of proteins was determined in blood plasma by reaction with 2,4-dinitrophenylhydrazine. Results In patients with psoriasis vulgaris, significant violations of the processes of oxidative modification of blood plasma proteins (spontaneous and metal-catalyzed) were detected. Conclusions. In patients with psoriasis vulgaris, the period of exacerbation of the disease, is accompanied by carbonyl stress, which is confirmed by a significant increase in the blood content of aldehyde and ketone phenylhydrazones.
Pelatihan dan Pembinaan Pedagang Kaki Lima di Perumahan Buana Impian Kota Batam
Authors: Wage Sunarto , Effendi Syahril , Tukino Tukino , Banjarnahor Haposan
Published: January 2023

Kegiatan pengabdian masyarakat ini diadakan diPerumahan Buana Impian 1 & 2 khusus untuk Pedagang Kaki Tua. Awalnya Perumahan Buana 1&2 memiliki satu RW 014 namun pada tahun 2016 Buana Impian 2 menjadiRW 028. Terdapat pertokoan disepanjang jalan Perumahan Buana Impian 1&2 dan terdapat 53 Pedagang asongan (PKL). Tujuan utama dari Pengabdian Kepada Masyarakat (PKM) ini adalah untuk membantu mengembangkan usaha Pedagang Kali Lima diPerumahan Buana Impian 1&2 dengan berbagai jenis kegiatan usaha seperti penjualan buah-buahan, sepatu, pakaian, sayuran, pakaian dan lain-lain yang pada gilirannya umumnya makanan/kuliner; Para PKL diberikan pelatihan dan bimbingan berupa ceramah dan diskusi yang membahas permasalahan yang dihadapi PKL diPerumahan Buana Impian 1 dan 2. Materi pendidikan dan pelatihan PKL tentang manajemen usaha dan kewirausahaan, pelatihan akuntansi pendapatan dan biaya, cara mempromosikan usaha dan akses permodalan yang dapat diperoleh PKL. Setelah mengikuti pelatihan dan pendidikan PKL, harapannya agar usahanya tumbuh dan berkembang dengan baik. Materi pendidikan dan pelatihan PKL tentang manajemen usaha dan kewirausahaan, pelatihan akuntansi pendapatan dan biaya, cara mempromosikan usaha dan akses permodalan yang dapat diperoleh PKL. Setelah mengikuti pelatihan dan pendidikan PKL, harapannya agar usahanya tumbuh dan berkembang dengan baik. Materi pendidikan dan pelatihan PKL tentang manajemen usaha dan kewirausahaan, pelatihan akuntansi pendapatan dan biaya, cara mempromosikan usaha dan akses permodalan yang dapat diperoleh pedagang asongan. Setelah mengikuti pelatihan dan pendidikan PKL, harapannya agar usahanya tumbuh dan berkembang dengan baik.
Invasive and non-invasive electrodes for successful drug and gene delivery in electroporation-based treatments
Authors: Malyško-Ptašinskė Veronika , Staigvila Gediminas , Novickij Vitalij
Published: January 2023

Electroporation is an effective physical method for irreversible or reversible permeabilization of plasma membranes of biological cells and is typically used for tissue ablation or targeted drug/DNA delivery into living cells. In the context of cancer treatment, full recovery from an electroporation-based procedure is frequently dependent on the spatial distribution/homogeneity of the electric field in the tissue; therefore, the structure of electrodes/applicators plays an important role. This review focuses on the analysis of electrodes and in silico models used for electroporation in cancer treatment and gene therapy. We have reviewed various invasive and non-invasive electrodes; analyzed the spatial electric field distribution using finite element method analysis; evaluated parametric compatibility, and the pros and cons of application; and summarized options for improvement. Additionally, this review highlights the importance of tissue bioimpedance for accurate treatment planning using numerical modeling and the effects of pulse frequency on tissue conductivity and relative permittivity values.
Evaluation of silk fibroin-based urinary conduits in a porcine model of urinary diversion
Authors: Gundogdu Gokhan , Nguyen Travis , Hosseini Sharifi Seyed Hossein , Starek Stephanie , Costa Kyle , Jones Clara E. , Barham David , Gelman Joel , Clayman Ralph V. , Mauney Joshua R.
Published: January 2023

Background:The primary strategy for urinary diversion in radical cystectomy patients involves incorporation of autologous gastrointestinal conduits into the urinary tract which leads to deleterious consequences including chronic infections and metabolic abnormalities. This report investigates the efficacy of an acellular, tubular bi-layer silk fibroin (BLSF) graft to function as an alternative urinary conduit in a porcine model of urinary diversion.

Materials and methods:Unilateral urinary diversion with stented BLSF conduits was executed in five adult female, Yucatan mini-swine over a 3 month period. Longitudinal imaging analyses including ultrasonography, retrograde ureteropyelography and video-endoscopy were carried out monthly. Histological, immunohistochemical (IHC), and histomorphometric assessments were performed on neoconduits at harvest.

Results:All animals survived until scheduled euthanasia and displayed moderate hydronephrosis (Grades 1–3) in reconstructed collecting systems over the course of the study period. Stented BLSF constructs supported formation of vascularized, retroperitoneal tubes capable of facilitating external urinary drainage. By 3 months post-operative, neoconduits containedα-smooth muscle actin+ and SM22α+ smooth muscle as well as uroplakin 3A+ and pan-cytokeratin + urothelium. However, the degree of tissue regeneration in neotissues was significantly lower in comparison to ureteral controls as determined by histomorphometry. In addition, neoconduit stenting was necessary to prevent stomal occlusion.

Conclusion:BLSF biomaterials represent emerging platforms for urinary conduit construction and may offer a functional replacement for conventional urinary diversion techniques following further optimization of mechanical properties and regenerative responses.
PHIP-associated Chung-Jansen syndrome: Report of 23 new individuals
Authors: Kampmeier Antje , Leitão Elsa , Parenti Ilaria , Beygo Jasmin , Depienne Christel , Bramswig Nuria C , Hsieh Tzung-Chien , Afenjar Alexandra , Beck-Wödl Stefanie , Grasshoff Ute , Haack Tobias B , Bijlsma Emilia K , Ruivenkamp Claudia , Lausberg Eva , Elbracht Miriam , Haanpää Maria K , Koillinen Hannele , Heinrich Uwe , Rost Imma , Jamra Rami Abou , Popp Denny , Koch-Hogrebe Margarete , Rostasy Kevin , López-González Vanesa , Sanchez-Soler María José , Macedo Catarina , Schmetz Ariane , Steinborn Carmen , Weidensee Sabine , Lesmann Hellen , Marbach Felix , Caro Pilar , Schaaf Christian P. , Krawitz Peter , Wieczorek Dagmar , Kaiser Frank J , Kuechler Alma
Published: January 2023

In 2016 and 2018, Chung, Jansen and others described a new syndrome caused by haploinsufficiency of PHIP (pleckstrin homology domain interacting protein, OMIM *612,870) and mainly characterized by developmental delay (DD), learning difficulties/intellectual disability (ID), behavioral abnormalities, facial dysmorphism and obesity (CHUJANS, OMIM #617991). So far, PHIP alterations appear to be a rare cause of DD/ID. “Omics” technologies such as exome sequencing or array analyses have led to the identification of distinct types of alterations of PHIP, including, truncating variants, missense substitutions, splice variants and large deletions encompassing portions of the gene or the entire gene as well as adjacent genomic regions. We collected clinical and genetic data of 23 individuals with PHIP-associated Chung-Jansen syndrome (CHUJANS) from all over Europe. Follow-up investigations (e.g. Sanger sequencing, qPCR or Fluorescence-in-situ-Hybridization) and segregation analysis showed either de novo occurrence or inheritance from an also (mildly) affected parent. In accordance with previously described patients, almost all individuals reported here show developmental delay (22/23), learning disability or ID (22/23), behavioral abnormalities (20/23), weight problems (13/23) and characteristic craniofacial features (i.e. large ears/earlobes, prominent eyebrows, anteverted nares and long philtrum (23/23)). To further investigate the facial gestalt of individuals with CHUJANS, we performed facial analysis using the GestaltMatcher approach. By this, we could establish that PHIP patients are indistinguishable based on the type of PHIP alteration (e.g. missense, loss-of-function, splice site) but show a significant difference to the average face of healthy individuals as well as to individuals with Prader-Willi syndrome (PWS, OMIM #176270) or with a CUL4B-alteration (Intellectual developmental disorder, X-linked, syndromic, Cabezas type, OMIM #300354). Our findings expand the mutational and clinical spectrum of CHUJANS. We discuss the molecular and clinical features in comparison to the published individuals. The fact that some variants were inherited from a mildly affected parent further illustrates the variability of the associated phenotype and outlines the importance of a thorough clinical evaluation combined with genetic analyses for accurate diagnosis and counselling.
Skeletal diseases caused by mutations in PTH1R show aberrant differentiation of skeletal progenitors due to dysregulation of DEPTOR
Authors: Csukasi Fabiana , Bosakova Michaela , Barta Tomas , Martin Jorge H. , Arcedo Jesus , Barad Maya , Rico-Llanos Gustavo A. , Zieba Jennifer , Becerra Jose , Krejci Pavel , Duran Ivan , Krakow Deborah
Published: January 2023

Alterations in the balance between skeletogenesis and adipogenesis is a pathogenic feature in multiple skeletal disorders. Clinically, enhanced bone marrow adiposity in bones impairs mobility and increases fracture risk, reducing the quality of life of patients. The molecular mechanism that underlies the balance between skeletogenesis and adipogenesis is not completely understood but alterations in skeletal progenitor cells’ differentiation pathway plays a key role. We recently demonstrated that parathyroid hormone (PTH)/PTH-related peptide (PTHrP) control the levels of DEPTOR, an inhibitor of the mechanistic target of rapamycin (mTOR), and that DEPTOR levels are altered in different skeletal diseases. Here, we show that mutations in the PTH receptor-1 (PTH1R) alter the differentiation of skeletal progenitors in two different skeletal genetic disorders and lead to accumulation of fat or cartilage in bones. Mechanistically, DEPTOR controls the subcellular localization of TAZ (transcriptional co-activator with a PDZ-binding domain), a transcriptional regulator that governs skeletal stem cells differentiation into either bone and fat. We show that DEPTOR regulation of TAZ localization is achieved through the control of Dishevelled2 (DVL2) phosphorylation. Depending on nutrient availability, DEPTOR directly interacts with PTH1R to regulate PTH/PTHrP signaling or it forms a complex with TAZ, to prevent its translocation to the nucleus and therefore inhibit its transcriptional activity. Our data point DEPTOR as a key molecule in skeletal progenitor differentiation; its dysregulation under pathologic conditions results in aberrant bone/fat balance.
Neuropathic pain: Mechanisms and therapeutic strategies
Authors: Petroianu Georg A. , Aloum Lujain , Adem Abdu
Published: January 2023

The physiopathology and neurotransmission of pain are of an owe inspiring complexity. Our ability to satisfactorily suppress neuropathic or other forms of chronic pain is limited. The number of pharmacodynamically distinct and clinically available medications is low and the successes achieved modest. Pain Medicine practitioners are confronted with the ethical dichotomy imposed by Hippocrates: On one hand the mandate of primum non nocere, on the other hand, the promise of heavenly joys if successful divinum est opus sedare dolorem. We briefly summarize the concepts associated with nociceptive pain from nociceptive input (afferents from periphery), modulatory output [descending noradrenergic (NE) and serotoninergic (5-HT) fibers] to local control. The local control is comprised of the “inflammatory soup” at the site of pain origin and synaptic relay stations, with an ATP-rich environment promoting inflammation and nociception while an adenosine-rich environment having the opposite effect. Subsequently, we address the transition from nociceptor pain to neuropathic pain (independent of nociceptor activation) and the process of sensitization and pain chronification (transient pain progressing into persistent pain). Having sketched a model of pain perception and processing we attempt to identify the sites and modes of action of clinically available drugs used in chronic pain treatment, focusing on adjuvant (co-analgesic) medication.
Native amine dehydrogenases can catalyze the direct reduction of carbonyl compounds to alcohols in the absence of ammonia
Authors: Fossey-Jouenne Aurélie , Ducrot Laurine , Jongkind Ewald P. J. , Elisée Eddy , Zaparucha Anne , Grogan Gideon , Paul Caroline E. , Vergne-Vaxelaire Carine
Published: January 2023

Native amine dehydrogenases (nat-AmDHs) catalyze the (S)-stereoselective reductive amination of various ketones and aldehydes in the presence of high concentrations of ammonia. Based on the structure of CfusAmDH from Cystobacter fuscus complexed with Nicotinamide adenine dinucleotide phosphate (NADP+) and cyclohexylamine, we previously hypothesized a mechanism involving the attack at the electrophilic carbon of the carbonyl by ammonia followed by delivery of the hydride from the reduced nicotinamide cofactor on the re-face of the prochiral ketone. The direct reduction of carbonyl substrates into the corresponding alcohols requires a similar active site architecture and was previously reported as a minor side reaction of some native amine dehydrogenases and variants. Here we describe the ketoreductase (KRED) activity of a set of native amine dehydrogenases and variants, which proved to be significant in the absence of ammonia in the reaction medium but negligible in its presence. Conducting this study on a large set of substrates revealed the heterogeneity of this secondary ketoreductase activity, which was dependent upon the enzyme/substrate pairs considered. In silico docking experiments permitted the identification of some relationships between ketoreductase activity and the structural features of the enzymes. Kinetic studies of MsmeAmDH highlighted the superior performance of this native amine dehydrogenases as a ketoreductase but also its very low activity towards the reverse reaction of alcohol oxidation.
Optimal cutoffs of growth discordance for the risk of preeclampsia in twin pregnancies: A single-center retrospective cohort study
Authors: Zhu Jie , An Ping , Zhao Huanqiang , Zhao Ying , Zhou Jizi , Zhou Qiongjie , Li Xiaotian , Xiong Yu
Published: January 2023

Objective

To explore the optimal cutoffs of growth discordance for the risk of preeclampsia in twin pregnancies.

Methods

A retrospective cohort study in a university hospital which included twins delivered from February 2013 to September 2020. Restrictive cubic spline (RCS) model was applied to the trend of intertwin birthweight difference (BWD) with the risk of preeclampsia. Logistic regression and subgroup analysis were performed to find the cut-off with statistical significance and clinical meaningfulness.

Results

A total of 2,631 women pregnant with twins were enrolled. RCS showed a nonlinear upward trend of preeclampsia with BWD, and the BWD of 15% was the initial rising point. With the confounders adjusted, only the group with BWD ≥ 25% was found to be significantly associated with an increased risk of preeclampsia (adjusted odds ratio [aOR], 2.44; 95% confidence interval [CI]: 1.74–3.42). Additionally, subgroup analysis showed that both monochorionic (MC) and small for gestational age (SGA) twins were more likely to complicate with preeclampsia.

Conclusion

The growth discordance of 15% during pregnancy may be the preventive point of preeclampsia, and 25% may be the interventional point.
Imaging and biophysical modelling of thrombogenic mechanisms in atrial fibrillation and stroke
Authors: Qureshi Ahmed , Lip Gregory Y. H. , Nordsletten David A. , Williams Steven E. , Aslanidi Oleg , de Vecchi Adelaide
Published: January 2023

Atrial fibrillation (AF) underlies almost one third of all ischaemic strokes, with the left atrial appendage (LAA) identified as the primary thromboembolic source. Current stroke risk stratification approaches, such as the CHA2DS2-VASc score, rely mostly on clinical comorbidities, rather than thrombogenic mechanisms such as blood stasis, hypercoagulability and endothelial dysfunction—known as Virchow’s triad. While detection of AF-related thrombi is possible using established cardiac imaging techniques, such as transoesophageal echocardiography, there is a growing need to reliably assess AF-patient thrombogenicity prior to thrombus formation. Over the past decade, cardiac imaging and image-based biophysical modelling have emerged as powerful tools for reproducing the mechanisms of thrombogenesis. Clinical imaging modalities such as cardiac computed tomography, magnetic resonance and echocardiographic techniques can measure blood flow velocities and identify LA fibrosis (an indicator of endothelial dysfunction), but imaging remains limited in its ability to assess blood coagulation dynamics. In-silico cardiac modelling tools—such as computational fluid dynamics for blood flow, reaction-diffusion-convection equations to mimic the coagulation cascade, and surrogate flow metrics associated with endothelial damage—have grown in prevalence and advanced mechanistic understanding of thrombogenesis. However, neither technique alone can fully elucidate thrombogenicity in AF. In future, combining cardiac imaging with in-silico modelling and integrating machine learning approaches for rapid results directly from imaging data will require development under a rigorous framework of verification and clinical validation, but may pave the way towards enhanced personalised stroke risk stratification in the growing population of AF patients. This Review will focus on the significant progress in these fields.
Allocation of water resources in the lower Yellow river based on ecological footprint
Authors: Zhang Shuiling , Li Hui , Li Chunhui , Yi Yujun , Wang Xuan , Liu Qiang
Published: January 2023

With the development of the economy, the contradiction of water resources in the lower Yellow River area is becoming increasingly serious. Economic development not only increases the socio-economic water demand, but also causes damage to the environment. In order to ensure the safety of the vast plains along the lower Yellow River, protect the environment of the lower Yellow River and estuaries, and achieve environmental sustainability of the lower Yellow River, a model was established to optimize the allocation of water resources with the goal of ecological, safety, and social benefits, combining the uncertainty of water resources, the uncertainty of the water demand during the flood season under different water and sediment conditions, and the water requirements of different water users. An improved ecological footprint method considering soil water was applied during the allocation. Thirty different scenarios were set up, and appropriate scenarios for 2025 and 2030 in wet, normal, and dry years were calculated, providing a reference for decision makers. Results show that: 1) The water supply is affected by the amount of water resources and water demand for sediment transport in the lower Yellow River. The satisfaction of sediment transport and the water supply rate during wet years can reach a high level of satisfaction. 2) When the regional water resources ecological footprint is the smallest, the allocation of water resources tends to the section or unit with a smaller ecological footprint. Therefore, the river sections with the lowest water shortage rates are Lijin-Hekou and Sunkou-Aishan, and the unit with a low water shortage is ecological and industrial water.
Investigation on unfrozen water content models of freezing soils
Authors: Bi Jun , Wang Guoxu , Wu Zhijian , Wen Haiyan , Zhang Yingmin , Lin Gaochao , Sun Tian
Published: January 2023

Unfrozen water content is a significant hydro-thermal property in numerical modeling in cold regions. Although numerous models have been developed to mimic the variation of unfrozen water content with subzero temperature, comprehensive evaluation of unfrozen water content models is scarce. This study collected a total of 29 models and divided them into four categories, namely, theoretical models, soil water characteristic curve (SWCC)-based models, empirical models, and estimation models. These models were evaluated with 1278 experimental points from 16 studies covering multiple soil types, including 24 clays, 18 silty clays, 7 silts, 19 sands, and 10 sandstones. Root mean square error and average deviations were applied to judge the performance of these models. Most unfrozen water content models can well simulate the relationship between unfrozen water content and subzero temperature. Among the aforementioned four categories of unfrozen water content models, Lizhm et al. model, Fredlund and Xing (C=1)-Wen model, Kozlowski empirical model, and Kozlowski estimation model performed best in their respective categories. Compared to the rest three categories, estimation models can be applied to predict the variation of unfrozen water content with subzero temperature by some easy-to-obtain soil physical parameters and provide guidance for the development of unfrozen water content models.