bluuebunny/crossref_metadata_2025 huggingface dataset:
Aplicaciones de la telerehabilitación en pacientes con Parkinson. Revisión sistemática
Authors: Sánchez Lozano Jesús , Martínez Pizarro Sandra
Published: December 2023

Introducción: El Parkinson es un trastorno neurodegenerativo, crónico y progresivo. A nivel mundial, la discapacidad a causa del Parkinson está incrementándose más rápidamente que las debidas a cualquier otro trastorno neurológico. Los pacientes Parkinson se enfrentan a numerosas barreras de acceso a los servicios de rehabilitación presenciales. Por ello, en los últimos años se ha propuesto la telerehabilitación como una posible solución a este problema. El objetivo principal de este trabajo es realizar una revisión de la literatura sobre las aplicaciones de la telerehabilitación en pacientes con Parkinson. Método: Se realizó una revisión siguiendo la normativa PRISMA. Se consultaron las bases de datos de PubMed, Cinahl, PsycINFO, SPORTDiscus, Academic Search Complete, Lilacs, IBECS, CENTRAL, SciELO y WOS. Se utilizó la herramienta Cochrane para valorar el riesgo de sesgo; la calidad de la evidencia se evaluó utilizando GRADE. Resultados: La telerehabilitación es eficaz en pacientes con Parkinson. La muestra total fue de 256 pacientes. El número de sesiones de telerehabilitación osciló entre 15 a 28 sesiones, con una duración de 40 a 90 minutos cada una de ellas. El tratamiento total duró entre 4 y 8 semanas y la frecuencia fue entre 1 y 3 veces por semana. Conclusiones: La telerehabilitación es una alternativa eficaz al tratamiento en clínica para reducir la inestabilidad postural, en la mejora del control postural, mantenimiento del habla y mejora de la fuerza. Esta terapia ofrece ventajas frente a la rehabilitación convencional presencial en clínica para los pacientes con dificultad para trasladarse.
OPTIMALISASI UPAYA DETASEMEN KHUSUS 88 MARKAS BESAR KEPOLISIAN ANTI TEROR
Authors: Herwin Herwin Sulistyowati
Published: December 2023

Upaya Densus 88 Anti Teror dalam penanganan tindak pidana terorisme di Indonesia dilakukan melalui tindakan preventif dan renfresif. Tindakan preventif ditujukan mengurangi kemungkinan terjadinya aksi teror, meliputi tehnik pencegahan kejahatan murni untuk memperkuat target serta prosedur untuk mendeteksi aksi teror. Faktor-faktor penghambat Detasemen Densus 88 Anti Teror dalam penanganan tindak pidana terorisme di Indonesia, antara lain: a) faktor sarana dan fasilitas, penggunaan teknologi yang canggih dapat menjadi suatu titik lemah pihak Detasemen 88 Anti Teror apabila pihak Detasemen 88 Anti Teror selalu bergantung kepada kecanggihan teknologi; b) Faktor Masyarakat, masih adanya dukungan terhadap tindak pidana terorisme dari sebagian masyarakat yang menganggap pelaku terorisme sebagai pahlawan; dan c) Faktor Budaya, ajaran agama tertentu yang disalahgunakan sebagai alasan pembenar tindak pidana terorisme, dengan menggunakan istilah Jihad sebagai pelindung membuat pelaku tindak pidana terorisme menganggap tindakan yang dilakukannya adalah benar sehingga dalam proses hukum pelaku tersebut tidak mau mengakui kesalahannya. Metode penelitian bersifat deskriptif, lokasi penelitian di Wilayah Hukum Polres Sukoharjo. Jenis penelitian adalah yuridis normatif. Data dan sumber data diperoleh dari data primer dan sekunder. hasil penenlitian menunjukkan bahwa Upaya Densus 88 Anti Teror dalam penanganan tindak pidana terorisme di Indonesia dilakukan melalui tindakan preventif dan renfresif.  Tindakan preventif ditujukan untuk  mengurangi kemungkinan terjadinya aksi teror, meliputi tehnik pencegahan kejahatan murni yang ditujukan untuk memperkuat target serta prosedur untuk mendeteksi aksi teror yang terencana Faktor-faktor penghambat Detasemen Densus 88 Anti Teror dalam penanganan tindak pidana terorisme di Indonesia, antara lain: a) faktor sarana dan fasilitas, penggunaan teknologi yang canggih dapat menjadi suatu titik lemah pihak Detasemen 88 Anti Teror apabila pihak Detasemen 88 Anti Teror selalu bergantung kepada kecanggihan teknologi; b) Faktor Masyarakat, masih adanya dukungan terhadap tindak pidana terorisme dari sebagian masyarakat yang menganggap pelaku terorisme sebagai pahlawan; dan c) Faktor Budaya, ajaran agama tertentu yang disalahgunakan sebagai alasan pembenar tindak pidana terorisme, dengan menggunakan istilah Jihad sebagai pelindung membuat pelaku tindak pidana terorisme menganggap tindakan yang dilakukannya adalah benar sehingga dalam proses hukum pelaku tersebut tidak mau mengakui kesalahannya
THE DEVELOPMENT OF ENTERPRISE ARCHITECTURE BUSINESS CRM AT PT. CAPELLA DINAMIK NUSANTARA WITH EAP METHODOLOGY
Authors: Bayu Rianto
Published: December 2023

One of the purposes of implementing the enterprise architecture is to create an alignment between business and information technology for organizational needs, the application of enterprise architecture is inseparable from how does an organization plan and designs the enterprise architecture. In designing enterprise architecture a complete and easy methodology is required. Enterprise Architecture Planning or often abbreviated as EAP is a method used to build information architecture. EAP is a method of data quality planning approach that is oriented to business needs and how the implementation of the architecture is carried out in such a way as to support the business cycle and the achievement of the contents of information systems and organizations.
PERANCANGAN MULTIMEDIA IKLAN BISNIS KULINER
Authors: Nurlianti  , Rasyid Ridha Muh.
Published: December 2023

Saat ini banyak perusahaan yang berkembang di bidang teknologi, fashion dan kuliner. Salah satu bisnis yang banyak diminati adalah bisnis kuliner. Promosi pemasaran yang baik sangat diperlukan untuk mendukung promosi usaha yang sedang berkembang. Dalam bisnis mie pedas maut, pemilik hanya mengiklankan dengan gambar produk. Teknik iklanan ini kurang menarik, tujuan dari perancangan multimedia iklan bisnis kuliner ini adalah membuat video iklan mie pedas maut dengan tampilan iklan yang lebih baik dan menarik agar konsumen membeli mie. Villamil molina digunakan sebagai metode penelitian dalam perancangan multimedia iklan bisnis kuliner ini. Penelitian ini menggunakan Fillmora 9 dalam proses editing video. Setelah itu dilakukan pengujian alfa dan beta untuk mengetahui kelayakan iklan video. Hasil perancangan multimedia iklan bisnis kuliner ini membuat video promosi Mie Pedas berdurasi 54 detik.
USABILITY ANALYSIS OF CAMSCANNER APPLICATIONS USING THE SYSTEM USABILITY SCALE (SUS) METHOD
Authors: Bagas Yana Prayoga
Published: December 2023

In the current digital era, technology has transformed the way we work and interact with the world around us. One significant development is the ability to convert physical documents into a digital format using scanning applications. One popular application for this task is CamScanner. This research aims to measure the CamScanner application's usability level using the System Usability Scale (SUS) analysis. The research method is a quantitative descriptive approach, aiming to provide a structured, accurate, and up-to-date understanding of the researched object. Data collection was conducted using a questionnaire created with Google Forms and distributed to 30 respondents. The findings of this research indicate that the CamScanner application exhibits usability with an acceptability level of "Acceptable," a grade of "B," and an adjective rating of "Good." This conclusion is based on calculating the average questionnaire score, which yielded a value of 74.2.
Pembuatan Kompos Sebagai Upaya Pemanfaatan Sampah Rumah Tangga
Authors: Karyati Karyati , Widiati Kusno Yuli , Mulyadi Rachmad , Karmini Karmini , 'Adani Rika Windarti , Rivanti Salsabila
Published: December 2023

Utilization of organic waste is one strategy that can be done in dealing with waste problems. The purpose of this community service was to improve skills in making compost from household organic waste and increase motivation to use household organic waste as compost in an effort to increase awareness of Clean and Healthy Living Behavior (PHBS). This counseling was carried out in collaboration with the Trigona Kelulut Makmur Bee Cultivation Group (KBLTKM) in Bangun Rejo Village, Tenggarong Seberang District, Kutai Kartanegara Regency, East Kalimantan Province. The community service was done by presentation, practice of making solid and liquid organic fertilizers from household organic waste, distribution of brochures (leaflets), discussion, and collecting feedback from extension participants. Counseling on making compost from household organic waste went well. Most of the participants had not used household organic waste and felt that this activity was very useful and increase their motivation to use household organic waste as compost.
MaGoGreen: Teknologi Bio-Konversi Sampah Organik Sebagai Pakan Ternak Alternatif Memanfaatkan Larva Black Soldier Fly
Authors: Yana Dewi Yuli , Muslimin Muslimin , Karyati Karyati , Sarminah Sri , Purwanti Emi , Karmini Karmini , Khairil hakim Nanda
Published: December 2023

Waste utilization and management in a number of areas in Indonesia is still a complicated problem. One of the wise waste management efforts is by utilizing bioconversion technology with Black Soldier Fly maggot media that known as MaGoGreen (Maggot Go Green). The purpose of this community service is to provide counseling to the community about the use of organic waste through environmentally friendly waste management with bioconversion technology by utilizing Black Soldier Fly Larvae. This activity is expected to be an effort to educate breeders to get cheap, safe, and quality feed independently. This counseling was carried out in collaboration with the Trigona Kelulut Makmur Bee Cultivation Group (KBLTKM) in Bangun Rejo Village, Tenggarong Seberang District, Kutai Kartanegara Regency, East Kalimantan Province. The community service methods used include material presentation, practice of maggot cultivation from the preparation stage, egg hatching and maggot enlargement to breeding, distribution of brochures (leaflets), and ends with discussions and questions-answers. Extension participants received knowledge about bio-conversion technology of organic waste as an alternative animal feed ingredient by utilizing Black Soldier Fly Larvae. Most of the participants also felt compelled to carry out independent processing of organic waste into livestock food products.
A szabálysértési törvény első évtizede
Authors: Skorka Tamás
Published: December 2023

A szabálysértésekről, a szabálysértési eljárásról és a szabálysértési nyilvántartási rendszerről szóló 2012. évi II. törvény (továbbiakban: Szabs. tv.) megalkotása óta több mint tizenegy év telt el. A hatálybalépését megelőzően és röviddel utána számos tudományos írás jelent meg, de az érdeklődés jelentős mértékben megcsappant. Még a 2022. év – a törvény egy évtizedes múltja – sem késztette értékelésre a jogtudomány művelőit. Mondhatnám, csekély társadalomra veszélyesség csekély tudományos érdeklődést generál. Írásomban a hatályos szabálysértési törvény elmúlt tíz évének jelentős mérföldköveit adó jogintézményeket veszem sorra.
Changes in peripheral blood parameters of lambs with spontaneous eimeriosis
Authors: Filipenko O. V.
Published: December 2023

In order to study the morphological and biochemical parameters of the blood of lambs affected by the causative agent of eimeria, an experimental group of animals of the Romanov breed, two months old, was formed. The lambs were spontaneously infected with the causative agent of eimeria, which was confirmed by laboratory and clinical studies. The second group of animals was free from eimeria and was kept separately. According to the results of blood tests of sick lambs, a decrease in the number of peripheral blood erythrocytes by 29.66 %, an increase in the total number of leukocytes by 47.12 % compared to the blood parameters of the control group of animals was revealed. A change in leukogram parameters was also noted: an increase in the number of eosinophils by 55.43 %, young neutrophils by 75 %. At the same time, there was a decrease in the number of rod-shaped neutrophils and an increase in the number of segmented neutrophils by 8.7 and 29.51 %, respectively. A decrease in the number of lymphocytes and monocytes by 31.68 and 12 %, respectively, was registered. Biochemical changes in the blood serum of sick lambs also underwent changes. A decrease in the content of total protein by 36.06 %, albumin by 13.09 % was established. An increase in the content of globulins and dysproteinemia was noted. Hemoglobin content was also reduced compared to blood parameters of healthy lambs by 32.25 %, as well as glucose content by 27.83 %. The activity level of ALT and AST increased by 43.43 and 33.15 %, respectively, as well as a slight decrease in GGT activity. The difference was statistically significant (Р < 0.01 and Р < 0.05). Differences in the blood parameters of sick lambs have been established and indicate a syndrome of the body's general inflammatory reaction, anemia, damage to the alimentary canal by the causative agent of eimeria and intoxication.
Сучасні політичні процеси: глобальний та національний виміри=Modern political processes: global and national dimensions : матеріали ІІІ Міжнародної науково-практичної інтернет-конференції (м.Одеса, 30 листопада 2023 р.)
Authors:   Національний університет «Одеська юридична академія»
Published: December 2023

ІІІ Міжнародна науково-практична інтернет конференція “Сучасні політичні процеси: глобальний та національний виміри”, ініційована к афедрою політичних теорій нашого університету, що відбулась 30 листопада 2023 року. В центрі уваги конференції, як в концептуальному так і в прикладному аспектах, були актуальні питання сьогодення та перспектив розвитку, важл иві для України і світової спільноти. Це, зокрема, питання демократичних трансформацій, необхідних для успішного демократичного транзиту України та її євроінтеграції; ефективності механізмів етнонаціональної, соціальної, культурної політики держави; першоч ергових кроків укріплення національної безпеки та їх пов’язаність з регіональною і глобальною безпекою; напрямів змін світового порядку та в системі міжнародних відносин задля формування широкого безпекового середовища сталого розвитку.
Governors and Electoral Hazard in the Allocation of US Federal Disaster Aid
Authors: Husted Thomas , Nickerson David
Published: December 2023

Public aid in the aftermath of an environmental dissaster may provide elected officials opportunities to engage in “electoral hazard,” where an incumbent can influence the probability of her reelection by allocating aid to influence voters’ expectations of their future welfare.  This is the first test for electoral hazard in the allocation of federal public aid to officials of local governments running for re-election. Using a unique U.S. county-level data set, we estimate the determinants of the equilibrium allocation strategy of an incumbent in the presence of electoral hazard. Controlling for loss and the demographic, economic and political characteristics of at-risk counties, we find the average incumbent governor seeking re-election actively engages in the manipulation of voter expectations by allocating greater shares and magnitudes of the largest federal disaster aid program to those at-risk counties that awarded the incumbent governor a plurality of votes in the preceding election. 
The interplay between satiation and temptation drives cleaner fish Labroides dimidiatus foraging behaviour and service quality towards client reef fish
Authors: Triki Zegni , Li Richter Xaing yi , Pinto Ana , Baud Antoine , Binning Sandra Ann , Aellen Melisande , Emery Yasmin , Staubli Virginie , Raihani Nichola , Bshary Redouan
Published: December 2023

Supply and demand affect the values of goods exchanged in cooperative trades where high demand typically leads to a higher price. An exception has been described in the marine cleaning mutualism involving the cleaner fish Labroides dimidiatus and its variety of ‘client’ coral reef fishes. Cleaner fish feed on clients’ ectoparasites but prefer eating clients’ mucus instead, which constitutes cheating. Here, we provide field observations, followed by a set of laboratory experiments with real clients and Plexiglas feeding plates as surrogates for clients. In the field and in three experiments with real clients, we found that satiated cleaner fish were more cooperative, even though low hunger levels should make them less dependent on cleaning interactions. Similarly, the more abstract version of the experiments using Plexiglas plates offering two food types mimicking client ectoparasites and mucus showed that satiation led cleaner fish to feed more against their preferences – an indicator of cooperative behaviour. However, this outcome occurred only if the temptation to eat the preferred food was low. When the temptation to cheat was high, cleaners did so. We provide further general support to these findings with a game-theoretic model. Many mutualisms involve food as a commodity. Thus, identifying foraging decision rules will enhance our understanding of how individuals adjust to real-time market conditions rather than playing evolved strategies adapted to the average market conditions.
Moderate Aerobic Exercise in College Students’ Memory Retention
Authors: Sumicad Rulthan , Vaño Julie Pearl A. , Gob Rosamaria P. , Olofernes Dennis E. , Dubouzet Ricci Francoise , Sevilla Ivyrose S. , Ladera Alben Kenth V.
Published: December 2023

This study was conducted to determine the effect of moderate aerobic exercise on memory retention of 1st-year Political Science students at the University of Cebu Main- Campus, Academic Year 2022-2023. It utilized the quantitative research method; thus, this study used a quasi-experimental pre-test and post-test design. The researchers used this design in conducting this study to evaluate if the intervention known as moderate aerobic exercise, precisely the brisk walk-in-place exercise, positively affects the students' memory retention. Moreover, this research design helps determine the effect of the treatment on the respondents before and after manipulation. Physical exercise has undeniably positive effects on both our bodies and minds. The scientific literature emphasizes its impact on our memory. The idea that something as simple as exercise, which anyone can do, has the potential to improve our memory is reason enough to investigate further. This will be especially beneficial for students, as having a good memory is a requirement for academic success. They chose them as the respondents in this study because their major requires much memorization, and they recently switched from online to face-to-face classes. This research aims to see if there is a difference in students' memory retention before and after moderate aerobic exercise. The research was motivated by the recognized positive influence of physical exercise on memory. It focused on its relevance to students who require strong memorization skills for academic success, especially considering the transition from online to in-person classes. The primary objective was to examine any variations in memory retention before and after moderate aerobic exercise. Individuals were given the challenge of memorizing 50 pairs of words within a ten-minute time frame. This task was repeated on the second, third, and fourth days, and a memory retention test was administered on the fifth day. While the overall results did not reveal a significant difference in memory recall, some participants showed modest improvements, suggesting potential benefits for certain students. The study recommends that future investigations consider factors such as IQ levels, learning preferences, diet, sleep duration, and life stressors, which could influence students' memory abilities.
ART, NATURE, AND MEMORY IN ETEL ADNAN’S JOURNEY TO MOUNT TAMALPAIS
Authors: ÖZBEK AKIMAN Özge
Published: December 2023

In her Journey to Mount Tamalpais: An Essay (1986), the Arab American painter and poet Etel Adnan (1925-2021) contemplates on the relationship between art, nature, and memory by focusing on the act of perception. Adnan’s text tells of her inner journey towards peace in contrast to her other work that responds to the Lebanese civil war, from which she had to flee in the 1970s. The centrality of perception reveals an intertwining relationship between art, nature and memory. In this relationship, the subject is intertwined with the object, self with the other, the perceiver with the perceived, which traditional Western thought separates as binaries. One of the prominent figures in phenomenological approach, Maurice Merleau-Ponty has focused on perception that is compatible with Adnan’s text. His concepts of “reversibility,” “chiasm,” “dehiscence,” and “flesh” are useful tools to analyze the essay both in its conceptual and cultural dimensions. As a work which incorporates verbal and visual treatments of the mountain, in which Adnan excavates the hidden histories and memories, retaining their differences, Journey to Mount Tamalpais proves to be a manifestation of “the intertwining—the chiasm” as Merleau-Ponty attempts to map. In relation to perception, memory emerges as a preeminent concept due to Adnan’s engagements with cultures and linguistic worlds such as Arab, French and American, and her witness of colonial wars. This article proposes a reading that captures the conceptual and cultural dimensions of the text, which ultimately leads to a new visibility of the mountain. The ultimate manifestation of Mount Tamalpais is the image of a wise and wounded old woman. When the process of perception that produces this image is analyzed from Merleau-Ponty’s perspective, Journey to Mount Tamalpais reveals a way of thinking about the chiasm of art, nature and memory in which the boundaries between subject and object, perceiver and perceived, and background and foreground collapse.
DERLEM TEMELLİ EŞDİZİMLİLİK ÇIKARIMINDA YÖNTEMSEL, ANLAMBİLİMSEL VE BİÇİMSÖZDİZİMSEL SÜREÇLER -PROJE TEMELLİ BİR DURUM ÇALIŞMASI-
Authors: GÜNDOĞDU Ayşe Eda
Published: December 2023

Derlem temelli anlam gösterimleri, içerisinde önüretimli yapılar, bilişsel şemalar, kültürel kodlar gibi dinamikleri barındırması nedeniyle biçimsel gösterimlerden farklı olarak tam otomatik olmaktan çok, doğal dil kullanıcılarının ve alan uzmanlarının yargılarına da gereksinim duymasından ötürü yarı-otomatik çıkarıma izin veren bir niteliktedir. Bu çalışmada dilde anlam örüntülerinin ve gösterimlerinin önemli bir bölümünü oluşturan eşdizimsel yapılanmaların derlem temelli çıkarımı sürecine ilişkin bir durum çalışması ortaya koymak amaçlanmıştır. Durum çalışmaları bir olguyu, özgül bağlamı içerisinde, olağan sürecinde, uygulama odaklı sunulan bir gerçeklikle, derinlemesine bir biçimde ortaya koymayı amaçlayan bir araştırma yöntemidir. Söz konusu çalışma disiplini, konu alanı ile ilgili gerçekleştirilmesi planlanan araştırmalara, deneyim temelli bir bakış açısıyla kuramsal çerçeveden uygulama süreçlerine doğru ilerleyen bir perspektif sunabilmektedir. Bu durum çalışması TÜBİTAK-SOBAG 3501 programı tarafından desteklenen, dilbilim alanında yürütülen bir araştırma projesi çerçevesinde yapılandırılmış ve yöntemsel süreç: verisetlerinin oluşturulması, örüntüleme düzlemlerini özgülleştirme ve veri işleme süreci, istatistiksel süreç, anlambilimsel süreç, biçim-sözdizimsel süreç olmak üzere beş farklı boyutta tasarlanmıştır. Çalışmanın temel motivasyonu, özelde eşdizimlilik çıkarımı, genelde dilsel örüntülerin derlem temelli betimlenmesi çerçevesinde süreç temelli ve görgül bir izlek ortaya koymaktır. Özellikle derlem dilbilim ve sözcükanlambilim arakesitinde uygulama ve süreç temelli yetkinlik kazanmayı planlayan araştırmacılara bütüncül ve disiplinlerarası bir rehber oluşturma açısından söz konusu çalışmanın önem taşıdığı düşünülmektedir.
BEHAVIORAL METHODS EMPLOYED TO INVESTIGATE THE STRUCTURE OF AUTOBIOGRAPHICAL MEMORIES
Authors: İNAN Aslı Bahar
Published: December 2023

Memory research conducted in laboratories require controlled experiments in order to eliminate the confounding factors that can affect memory retrieval. However autobiographical memories require the retrieval of distant memories which are most of the time not verifiable. Due to the differences related to Autobiographical memory these controlled experiments cannot be used and different methods are required. Cue word technique, diary studies, recording event by using devices, Autobiographical Memory Interview and Autobiographical Interview are some of the behavioral methods employed for Autobiographical memory research. These methods have both some advantages and some disadvantages, which should be considered before they are used. The findings from the studies employing these methods indicated that Autobiographical memory has a hierarchical organization, it consists of a sementic component and an episodic component, and some of the cues are ineffective for the retrieval of autobiographical memories. Most of these methods can also be employed in research investigating the impaired components of autobiographical memory for patients with memory disorders like Alzheimer’s disease. In this review the bahavioral methods empleyed to investigate the structure of Autobiographical memories will be explored. First the differences of autobiographical memory from memory investigated in laboratory and the need for different methods in autobiographical memory research will be mentioned. Then behavioral methods to investigate the structure of Autobiographical memory, how they are used and the findings obtained from these studies seperately and in common will be discussed.
HÂREZM’İN MÜSLÜMANLAR TARAFINDAN FETHİ (32-93/652-712)
Authors: ÖZBAYRAKTAR Aykut
Published: December 2023

Tarihi Hârezm bölgesi 93/712 yılında Emevîlerin Horasan Valisi Kuteybe b. Müslim el-Bâhilî’nin komuta ettiği bir harekatla Müslümanlar tarafından fethedilmiştir. Bununla birlikte İslamî yazılı kaynaklar Müslümanların Hârezm’i fetih maksadıyla Kuteybe’den evvel, 32-85/652-704 yılları arasında farklı tarihlerde beş defa daha harekat düzenlediklerini ve bunların dördünde başarılı olduklarını da bildirmişlerdir. Bu makale Müslümanların Hârezm’e karşı tertipledikleri altı farklı askeri harekatı incelemektedir ve yorumlamaktadır. Konuyla ilgili rivayetleri ve araştırmacıların ileri sürdükleri görüşleri arkeolojik ve nümismatik bulguları da dikkate alarak değerlendirmekte ve eleştirmektedir. Sonuç itibariyle Müslümanların Hârezm’i ele geçmesi zor ve getirisi az, ikincil bir hedef olarak kabul ettikleri anlaşılmaktadır. Görünüşe göre bu durum, Hârezm’in geniş çöller tarafından kuşatılmış coğrafi konumuyla ve doğal sınırlarıyla alakalıdır. Kuteybe b. Müslim’den önce Hârezm’e yönelen ilk beş harekattan ilki, iklim koşulları nedeniyle yarıda kesilmiştir. Diğer dört harekatın ise tam bir fetihten ziyade çatışmaya girmeksizin haraç ve tutsak almak suretiyle tamamlanan operasyonlardan ibaret oldukları söylenebilir. Kuteybe’nin harekatı ise öncüllerine kıyasla çok farklı şartlar altında gerçekleşmiştir. Hârezm hükümdarının talebi ve daveti üzerine ani bir baskın yaparak bölgeyi kontrol altına alan Kuteybe b. Müslim, müttefikiyle anlaşmasının gereğince Hârezm’de İslam egemenliğine ve Müslümanlarla işbirliği halindeki mahalli hükümete karşı çıkabilecek tüm muhalif unsurları bertaraf etmiştir. Hârezmli askeri birlikleri de ordusuna katarak İslam hakimiyeti için tehdit olmaktan çıkaran Kuteybe bu suretle Hârezm’i kalıcı olarak geniş İslam aleminin bir parçası haline getirmiştir.
KONULARI BAKIMINDAN İRAN'DA SÖYLENEN FARSÇA NİNNİLER ÜZERİNE BİR DEĞERLENDİRME
Authors: GEDİK Melek
Published: December 2023

Sözlü edebiyat ürünleri arasında yer alan ninni çocuğun annesinden ilk işittiği kısa, yalın ve ritimli sözlerdir. Anne, dışarıdan herhangi bir müdahale olmaksızın söylediği bu ritimli ve nağmeli sözler aracılığıyla çocuğu ile ilk dilsel bağı kurmaktadır. Çocuğu uyutmak ve sakinleştirmek için söylenen bu sözler aynı zamanda bir toplumun dil, kültür ve sosyolojik özellikleri hakkında bilgi sunmaktadır. Ninniler genellikle anne tarafından icra edildiğinden kadın, sözlü kültür mirasının nesilden nesile aktarılmasında önemli bir rol üstlenmektedir. Anne, çocuğu doğduğu andan itibaren onun erken dönem eğitimini ninniler vasıtasıyla desteklemektedir. Çocuğa yaşadığı çevreyi, dilini, kültürünü, dinini, inançlarını, ulusal değerlerini tanıtarak onlarla bağ kurmasını ve içselleştirmesini sağlamada öğrenilmesi kolay ve akılda kalıcılığı yüksek olan ninnilerin etkisi büyüktür. Aynı zamanda anne kendine has bir üslupla dile getirdiği ninnilerde duygularını, isteklerini, sıkıntılarını ve beklentilerini iletmektedir. Bu bağlamda ninniler aile yapısının özelliklerini, aile bireyleri arasındaki ilişkileri, anne ve babanın aile içerisindeki rollerini ortaya koymaktadır.

Ninniler İran’da halk edebiyatının önemli bir bölümünü oluşturmaktadır. Halk edebiyatı ile ilgilenen İranlı birçok araştırmacı derleme faaliyetlerinde bulunarak ülkenin farklı bölgelerinden derledikleri ninnilere eserlerinde yer vermişlerdir. Bunun yanı sıra ninninin tanımı, muhtevası ve işlevi konusunda akademik anlamda birçok çalışma da kaleme alınmıştır. Bu çalışmada İran’da ninni konusunda yapılan tanımlamalar ve İran halk edebiyatında ninnilerin yeri ve önemi hakkında genel bilgiler verildikten sonra araştırmacıların İran’ın çeşitli şehirlerinden derlediği ninni örnekleri yapı ve konu bakımından değerlendirilecektir.
A mathematical model with fractional order for obesity with positive and negative interactions and its impact on the diagnosis of diabetes
Authors: DELGADO MOYA Erick Manuel , PİETRUS Alain , BERNARD S´everine , PAUL	NUİRO Silvere
Published: December 2023

Overweight and obesity are current problems humankind faces and have serious health consequences because they contribute to diseases such as heart diseases and diabetes. In this paper, we present a mathematical model for the study of overweight and obesity in a population and its impact on the growth of the number of diabetics. For the construction of the model, we take into account social factors and the interactions between different elements of society. We use fractional-order derivatives in the Caputo sense because of the advantages of this type of technique with respect to the memory effect, and it shows different behaviors depending on the fractional order. We find the basic reproduction number and prove the local and global stability of the disease-free equilibrium points. We study the sensitivity index with respect to the basic reproduction number for parameters associated with weight gain due to social pressure and the rate of diagnosis of diabetes not associated with body weight. To validate the model, we perform computational simulations with data extracted from the literature.
We conclude that for higher fractional orders a higher value of the basic reproduction number was reached. We show that at the end of the study for different fractional orders that normal-weight individuals are decreasing, and overweight, obese, and diabetic people are increasing.
Açık Kambiyo Senetlerinin Zayi Olması ve İptali
Authors: MERSİN Bilge Utkan
Published: December 2023

Türk Ticaret Kanununun 651 hükmü uyarınca kıymetli evrak zayi olduğu veya zıyaın ortaya çıktığı anda senet üzerindeki hak sahibi, mahkemeye başvurarak senedin iptaline karar verilmesini isteyebilir. Kambiyo senetlerinin zayi olması durumunda ise TTK m. 757 ve devamı hükümleri uyarınca senet iptal edilebilir. Bununla birlikte açık senetlerin zayi olması durumunda senedin iptal edilip edilmeyeceği hususunda yasal bir düzenleme bulunmamaktadır. Öğretide ve yargı içtihatlarında ise genel olarak açık senedin zayi olduğu durumda iptal hükümlerinin uygulama alanı bulacağı görüşü hakim olsa da bu uygulamanın nasıl olacağı tartışmalıdır. Bu çalışmada, kambiyo senetlerinin iptaline ilişkin hükümlerin açık senetler bakımından uygulanıp uygulanmayacağı sorunu incelenecektir.
Özel Statülü Yabancıların Türkiye’de Görülen Kişi Hallerine İlişkin Davalarında Usule ve Uygulanacak Hukukun Belirlenmesine İlişkin Bazı Tespitler
Authors: SÜZEN Begüm
Published: December 2023

5901 sayılı Türk Vatandaşlığı Kanunu’nun 28. maddesi uyarınca, doğumla Türk vatandaşı olup çıkma izni almak suretiyle Türk vatandaşlığını kaybeden yabancıların (mavi kart sahibi yabancılar), söz konusu hükümde öngörülen istisnalar haricinde, Türk vatandaşlarına tanınan haklardan aynen yararlanmaya devam etmeleri, bu kişilerin, Türk mahkemeleri önünde tarafı oldukları kişi hallerine ilişkin uyuşmazlıklarda, milletlerarası usul hukuku ve kanunlar ihtilafı hukukuna ilişkin bazı tartışmaları gündeme getirmektedir. Bu kapsamda, mavi kart sahibi yabancıların, belirli istisnalar haricinde Türk vatandaşları ile aynı statüde oldukları düşüncesinden hareketle, doktrinde ve yargı kararlarında, kişi hallerine ilişkin uyuşmazlıklarda milletlerarası yetkinin, MÖHUK’ un Türk vatandaşlığına bağlı yetki tesisi öngören 41. maddesi uyarınca belirlenip belirlenemeyeceği; bu kişilerin Türk mahkemelerinde açacakları davalarda “yabancı” statüsüne bağlı bir teminat yükümlülükleri olup olmayacağı ve adli yardımdan faydalanabilmelerinin “karşılıklılık” koşuluna bağlı olup olmadığı tartışılmaktadır. Diğer taraftan, söz konusu uyuşmazlıklarda uygulanacak hukukun vatandaşlık esasına göre belirlendiği hallerde, Türk vatandaşlarına tanınan haklardan aynen yararlanmanın, yabancı statüsünü ortadan kaldırıp kaldırmayacağı ve bu bağlamda, milli hukuk olarak Türk hukukunun uygulanıp uygulanamayacağı meselesi gündeme gelmektedir. Söz konusu tartışmalar, mavi kart sahiplerinin yanı sıra, kanunda öngörülen istisnalar haricinde Türk vatandaşlarına tanınan haklardan yararlanan diğer özel statülü yabancılar bakımından da geçerlidir. Bu makalede, söz konusu meseleler, sırasıyla değerlendirilecektir.
Effect of a transcultural nursing course on improving the cultural competency of nursing graduate students in Korea: a before-and-after study
Authors: Bae Kyung Eui , Jeong Geum Hee
Published: December 2023

Purpose: This study aimed to evaluate the impact of a transcultural nursing course on enhancing the cultural competency of graduate nursing students in Korea. We hypothesized that participants’ cultural competency would significantly improve in areas such as communication, biocultural ecology and family, dietary habits, death rituals, spirituality, equity, and empowerment and intermediation after completing the course. Furthermore, we assessed the participants’ overall satisfaction with the course.Methods: A before-and-after study was conducted with graduate nursing students at Hallym University, Chuncheon, Korea, from March to June 2023. A transcultural nursing course was developed based on Giger & Haddad’s transcultural nursing model and Purnell’s theoretical model of cultural competence. Data was collected using a cultural competence scale for registered nurses developed by Kim and his colleagues. A total of 18 students participated, and the paired t-test was employed to compare pre-and post-intervention scores.Results: The study revealed significant improvements in all 7 categories of cultural nursing competence (P<0.01). Specifically, the mean differences in scores (pre–post) ranged from 0.74 to 1.09 across the categories. Additionally, participants expressed high satisfaction with the course, with an average score of 4.72 out of a maximum of 5.0.Conclusion: The transcultural nursing course effectively enhanced the cultural competency of graduate nursing students. Such courses are imperative to ensure quality care for the increasing multicultural population in Korea.
Varieties of Anxieties: Disaggregating Emotion and Voting Behavior in the COVID-19 Era
Authors: Lall Ranjit , Vilalta David
Published: December 2023

How does anxiety influence voting behavior? Whereas anxiety is usually treated as a unidimensional emotion, we highlight the multiplicity of socially contingent forms it can assume in response to societal threats. Different anxieties, we posit, can create distinct axes of political competition along which anxious voters exhibit widely varying preferences. We illustrate our argument with unique observational and experimental survey data from Spain’s COVID-19 crisis, showing that individuals anxious about the pandemic’s health consequences consistently favored parties advocating stringent lockdown restrictions, whereas individuals anxious about its economic disruption preferred parties opposing such measures. Analyzing results from Madrid’s 2021 regional election, we additionally provide evidence that COVID-19 boosted support for pro-lockdown parties in areas more exposed to its health effects and support for anti-lockdown parties in areas more exposed to its economic impact. Our findings point to the importance of disaggregating complex emotional states for understanding the determinants of voting behavior.
A comprehensive review and comparison of L-tryptophan biosynthesis in Saccharomyces cerevisiae and Escherichia coli
Authors: Ren Xinru , Wei Yue , Zhao Honglu , Shao Juanjuan , Zeng Fanli , Wang Zhen , Li Li
Published: December 2023

L-tryptophan and its derivatives are widely used in the chemical, pharmaceutical, food, and feed industries. Microbial fermentation is the most commonly used method to produce L-tryptophan, which calls for an effective cell factory. The mechanism of L-tryptophan biosynthesis in Escherichia coli, the widely used producer of L-tryptophan, is well understood. Saccharomyces cerevisiae also plays a significant role in the industrial production of biochemicals. Because of its robustness and safety, S. cerevisiae is favored for producing pharmaceuticals and food-grade biochemicals. However, the biosynthesis of L-tryptophan in S. cerevisiae has been rarely summarized. The synthetic pathways and engineering strategies of L-tryptophan in E. coli and S. cerevisiae have been reviewed and compared in this review. Furthermore, the information presented in this review pertains to the existing understanding of how L-tryptophan affects S. cerevisiae’s stress fitness, which could aid in developing a novel plan to produce more resilient industrial yeast and E. coli cell factories.
Case Report: Imaging features of a new type double inferior vena cava malformation and review
Authors: Wu Yu-lin , Yang Guo-kai , Chen Qian , Tang Yi , Zhang Jian-hui , Wu Shao-jie , Cai Sen-lin , Zhou Yan-feng , Zhu Yao-Bin , Luo Jie-wei , Fang Zhu-ting
Published: December 2023

Background

Double inferior vena cava (DIVC) is a rare vascular malformation. With advances in radiological techniques and diagnosis, more and more types of DIVC were identified and diagnosed. Recognition of the variety of DIVC seen on imaging is essential for subsequent venous interventions.

Case presentation

A 77-year-old man presented with low back pain with left lower limb pain for 1 month. Scattered petechiae above the skin surface on the left lower leg, especially on the extensor surface, with flaking and mild tingling of the skin, were noted 3 weeks ago. Ultrasound revealed deep vein thrombosis (DVT) in the left lower limb. Computed tomography pulmonary angiography (CTPA) suggested no significant thrombus in the pulmonary artery. Computed tomography venography (CTV) of bilateral lower limbs showed that iliac vein compression syndrome with formation of deep and superficial venous traffic branches in bilateral lower limbs, predominantly on the left side. CTV of the inferior vena cava (IVC) suggested that the left common iliac vein crossed the common iliac artery bifurcation from dorsal to ventral and continued to travel cranially as a ventral vessel, and connected with the ventral IVC anterior to the right common iliac artery. The right common iliac vein extended cephalad as a dorsal vessel, which was narrowed at the level of 4th lumbar vertebra by compression of the hyperplastic bone and the osteophyte. The patient was discharged after right and left common iliac vein angiography and balloon dilation of bilateral common iliac vein.

Conclusion

The formation of both ventrally and dorsally aligned DIVC is rarer. It should be clarified the effects of DIVC on DVT formation, and the importance of imaging for preoperative planning.
HNF4α isoforms regulate the circadian balance between carbohydrate and lipid metabolism in the liver
Authors: Deans Jonathan R. , Deol Poonamjot , Titova Nina , Radi Sarah H. , Vuong Linh M. , Evans Jane R. , Pan Songqin , Fahrmann Johannes , Yang Jun , Hammock Bruce D. , Fiehn Oliver , Fekry Baharan , Eckel-Mahan Kristin , Sladek Frances M.
Published: December 2023

Hepatocyte Nuclear Factor 4α (HNF4α), a master regulator of hepatocyte differentiation, is regulated by two promoters (P1 and P2) which drive the expression of different isoforms. P1-HNF4α is the major isoform in the adult liver while P2-HNF4α is thought to be expressed only in fetal liver and liver cancer. Here, we show that P2-HNF4α is indeed expressed in the normal adult liver at Zeitgeber time (ZT)9 and ZT21. Using exon swap mice that express only P2-HNF4α we show that this isoform orchestrates a distinct transcriptome and metabolome via unique chromatin and protein-protein interactions, including with different clock proteins at different times of the day leading to subtle differences in circadian gene regulation. Furthermore, deletion of the Clock gene alters the circadian oscillation of P2- (but not P1-)HNF4α RNA, revealing a complex feedback loop between the HNF4α isoforms and the hepatic clock. Finally, we demonstrate that while P1-HNF4α drives gluconeogenesis, P2-HNF4α drives ketogenesis and is required for elevated levels of ketone bodies in female mice. Taken together, we propose that the highly conserved two-promoter structure of the Hnf4a gene is an evolutionarily conserved mechanism to maintain the balance between gluconeogenesis and ketogenesis in the liver in a circadian fashion.
Single-cell profiling reveals transcriptomic signatures of vascular endothelial cells in non-healing diabetic foot ulcers
Authors: Lu Yangzhou , Liu Xiaogang , Zhao Jingling , Bie Fan , Liu Yiling , Xie Julin , Wang Peng , Zhu Junyou , Xiong Yahui , Qin Shitian , Yang Fan , Chen Lei , Xu Yingbin
Published: December 2023

Background

The treatment of diabetic foot ulcers (DFUs) poses a challenging medical problem that has long plagued individuals with diabetes. Clinically, wounds that fail to heal for more than 12 weeks after the formation of DFUs are referred to as non-healing/chronic wounds. Among various factors contributing to the non-healing of DFUs, the impairment of skin microvascular endothelial cell function caused by high glucose plays a crucial role. Our study aimed to reveal the transcriptomic signatures of non-healing DFUs endothelial cells, providing novel intervention targets for treatment strategies.

Methods

Based on the GEO dataset (GSE165816), we selected DFU-Healer, DFU-Non-healer, and healthy non-diabetic controls as research subjects. Single-cell RNA transcriptomic sequencing technology was employed to analyze the heterogeneity of endothelial cells in different skin tissue samples and identify healing-related endothelial cell subpopulations. Immunofluorescence was applied to validate the sequencing results on clinical specimens.

Results

The number of endothelial cells and vascular density showed no significant differences among the three groups of skin specimens. However, endothelial cells from non-healing DFUs exhibited apparent inhibition of angiogenesis, inflammation, and immune-related signaling pathways. The expression of CCND1, ENO1, HIF1α, and SERPINE1 was significantly downregulated at the transcriptomic and histological levels. Further analysis demonstrated that healing-related endothelial cell subpopulations in non-healing DFUs has limited connection with other cell types and weaker differentiation ability.

Conclusion

At the single-cell level, we uncovered the molecular and functional specificity of endothelial cells in non-healing DFUs and highlighted the importance of endothelial cell immune-mediated capability in angiogenesis and wound healing. This provides new insights for the treatment of DFUs.
Classification of breed combinations for slaughter pigs based on genotypes—modeling DNA samples of crossbreeds as fuzzy sets from purebred founders
Authors: Vinje H. , Brustad H. K. , Heggli A. , Sevillano C. A. , Van Son M. , Gangsei L. E.
Published: December 2023

In pig production, the production animals are generally three- or four-way crossbreeds. Reliable information regarding the breed of origin of slaughtered pigs is useful, even a prerequisite, for a number of purposes, e.g., evaluating potential breed effects on carcass grading. Genetic data from slaughtered pigs can easily be extracted and used for crossbreed classification. In the current study, four classification methods, namely, random forest (RF), ADMIXTURE, partial least squares regression (PLSR), and partial least squares together with quadratic discriminant analysis (PLS-QDA) were evaluated on simulated (n = 7,500) genomic data of crossbreeds. The derivation of the theory behind PLS-QDA is a major part of the current study, whereas RF and ADMIXTURE are known and well-described in the literature. Classification success (CS) rate, square loss (SL), and Kullback–Leibler (KL) divergence loss for the simulated data were used to compare methods. Overall, PLS-QDA performed best with 99%/0.0018/0.002 (CS/SL/KL) vs. 97%/0.0084/0.051, 97%/0.0087/0.0623, and 17%/0.068/0.39 for PLSR, ADMIXTURE, and RF, respectively. PLS-QDA and ADMIXTURE, as the most relevant methods, were used on a real dataset (n = 1,013) from Norway where the two largest classes contained 532 and 192 (PLS-QDA), and 531 and 193 (ADMIXTURE) individuals, respectively. These two classes were expected to be dominating a priori. The Bayesian nature of PLS-QDA enables inclusion of desirable features such as a separate class “unknown breed combination” and informative priors for crossbreeds, making this a preferable method for the classification of breed combination in the industry.
ncRNAs: an unexplored cellular defense mechanism in leprosy
Authors: Santana-da-Silva Mayara Natália , Sena-dos-Santos Camille , Cáceres-Durán Miguel Ángel , Souza Felipe Gouvea de , Gobbo Angelica Rita , Pinto Pablo , Salgado Claudio Guedes , dos Santos Sidney Emanuel Batista
Published: December 2023

Leprosy is an infectious disease primarily caused by the obligate intracellular parasite Mycobacterium leprae. Although it has been considered eradicated in many countries, leprosy continues to be a health issue in developing nations. Besides the social stigma associated with it, individuals affected by leprosy may experience nerve damage leading to physical disabilities if the disease is not properly treated or early diagnosed. Leprosy is recognized as a complex disease wherein socioenvironmental factors, immune response, and host genetics interact to contribute to its development. Recently, a new field of study called epigenetics has emerged, revealing that the immune response and other mechanisms related to infectious diseases can be influenced by noncoding RNAs. This review aims to summarize the significant advancements concerning non-coding RNAs in leprosy, discussing the key perspectives on this novel approach to comprehending the pathophysiology of the disease and identifying molecular markers. In our view, investigations on non-coding RNAs in leprosy hold promise and warrant increased attention from researches in this field.