bluuebunny/crossref_metadata_2025 huggingface dataset:
Lobed Ware in the Far East from the Neolithic to the Middle Ages
Authors:   Institute of Archaeology and Ethnography, Siberian Branch, Russian Academy of Sciences, Medvedev V. E.
Published: December 2023

В работе рассматривается проблема времени возникновения и существования т.н. дольчатой керамики на Дальнем Востоке. Так называют сосуды, оформленные неглубокими вертикальными желобками (реже глубокими широкими вмятинами) в наиболее выпуклой части или на всем тулове. Иногда глиняная посуда покрывалась группами вертикальных резных линий или пролощенных, изредка крашеных лент, что имитировало дольчатость. В особо большом количестве данная керамика найдена при раскопках различных памятников чжурчжэньской эпохи в Приамурье (VII-XIII вв.). Обнаружена она также в Приморье, на северо-востоке КНР и других соседних территориях. Изучение различных источников показало, что глиняная дольчатая посуда изготавливалась в Нижнем Приамурье уже в неолите (V- конец II тыс. до н.э.). Наиболее ранние образцы принадлежат кондонской культуре, характерные дольчатые изделия известны в малышевской и вознесеновской. В статье впервые обосновывается положение о, видимо, прямом влиянии на раннее чжурчжэньско-бохайское гончарство, в т.ч. производство дольчатых сосудов, керамических традиций обществ Корейского полуострова первых двух-трех четвертей I тыс. н.э. Учитывая дискретность традиций, можно предположить, что это влияние в форме реминисценций сказывалось в Приамурье с неолита.
Corvids in the Buryat Traditional Worldview
Authors:   Institute of Archaeology and Ethnography, Siberian Branch, Russian Academy of Sciences, Badmaev A. A.
Published: December 2023

Рассматриваются образы ворона и вороны в мифологических представлениях бурят. Источниками для исследования послужили этнографические, лексические и фольклорные материалы. Основу исследования составили структурно-семиотический и сравнительно-исторический методы. Доказывается монгольское происхождение бурятских номинаций указанных птиц. Выявлено, что в бурятских народных воззрениях образ ворона представлен полнее, чем образ вороны. Образ ворона имеет неоднозначную коннотацию и полисемантичен; образу вороны дается сугубо отрицательная характеристика. Анализ лексики и малых жанров фольклора показывает, что буряты обращали внимание на внешние зоологические признаки этих птиц: у вороны отмечали цвет оперения, крик; у ворона — цвет оперения, его размеры и клюв, длительность полета; также учитывали поведенческие особенности: у ворона выделяли коллективное начало, эмоциональность выражения радости, жадность. Считалось, что природа обоих стервятников была нечистая. По мифологическим представлениям бурят, ворон являлся символом неба, весны, зоркости, войны, имел мужское начало, отличался мстительностью, хтоническим характером, выступал помощником буддийского божества. У него выделяли интеллект и независимость. Считалось, что ворону, в отличие от вороны, покровительствовали темные духи-хозяева и другие демонологические персонажи. Согласно народным воззрениям бурят, ворона была символом неба, зимы, воды, кровожадности, распространения молвы, имела женскую природу. Определено, что с обеими птицами связывалась идея оборотничества. Показано, что в традиционном мировоззрении бурят сочетались как отличительные этнические, так и общечеловеческие представления о воронах.
Origin of the Andronovans: A Statistical Approach
Authors:   Peter the Great Museum of Anthropology and Ethnography (Kunstkamera), Russian Academy of Sciences, Kozintsev A. G.
Published: December 2023

Происхождение андроновского населения изучено с помощью подхода, основанного не на типологии, а на статистике. Поставлено четыре вопроса. Какие восточноевропейские популяции среднего и переходного периода к позднему бронзовому веку участвовали в сложении андроновских? Какой вклад в данный процесс внесли южные группы? Какова роль сибирского субстрата? Какова популяционная подоплека различий между главными культурными традициями — федоровской и алакульской? Для решения этих вопросов привлечены 12 мужских андроновских краниологических серий (девять федоровских и три алакульские), а также 85 серий из Восточной Европы, Сибири, Казахстана, Средней Азии, Закавказья и с Ближнего Востока. Данные обработаны с помощью канонического анализа. Построены минимальные остовные деревья. Анализ показал, что наиболее вероятные предки андроновцев — поздние катакомбники Северного Кавказа, полтавкинцы, синташтинцы и представители абашевско-синташтинского горизонта. Прямых параллелей с закавказскими, среднеазиатскими и ближневосточными популяциями у андроновцев нет, но южный компонент мог быть унаследован ими либо от абашевцев, либо от катакомбников. В первом случае нужно постулировать градиент Фатьяново -> Баланово -> Абашево -> Синташта -> Петровка -> Андроново; во втором внутриандроновская изменчивость непосредственно выводится из внутрикатакомбной. Андроновские группы сибирского тяготения демонстрируют разные стадии «взаимной ассимиляции» мигрантов и домонголоидных автохтонов. Различия между федоровцами и алакульцами достоверны, но очень малы. Особая роль петровской группы в возникновении алакульской традиции анализом не подтверждается.
Archaeology and Ethnography of the Amur Region
Authors:   Amur State University, Junzheng Wang , Shuai Wang ,   Amur State University, Volkov D.P. ,   State Autonomous Institution “Center for the Preservation of the Historical and Cultural Heritage of the Amur Region”, Zabiyako A.A. ,   Amur State University, Zabiyako A.P ,   Amur State University, Zinenko Y.V. ,   Amur State University, Kovalenko S.V. ,   State Autonomous Institution “Center for the Preservation of the Historical and Cultural Heritage of the Amur Region”, Kontaleva E.A. ,   Amur State University, Medvedev V.E. ,   Institute of Archaeology and Ethnography, Siberian Branch, Russian Academy of Sciences, Mironov M.A. ,   State Autonomous Institution “Center for Preservation of Historical and Cultural Heritage of the Amur Region”, Nesterov S.P. ,   Institute of Archaeology and Ethnography, Siberian Branch, Russian Academy of Sciences, Pelevina O.V. ,   Amur State University, Tabarev A.V. ,   Institute of Archaeology and Ethnography, Siberian Branch, Russian Academy of Sciences, Chirkov N.V. ,   Institute of St. Tomas Aquinas,   Department of the Pontifical Salesian,   Amur State University
Published: December 2023

Th e book is dedicated to the anniversary of Academician A.P. Derevianko. Th e monograph systematizes the results of archaeological and ethnographic studies of the right and left banks of the Upper and Middle Amur River, reveals the current state of archaeological and ethnographic knowledge about the Amur region. Th e content of the book covers all historical epochs. Special attention is paid to those epochs in the study of which the greatest contribution was made by A.P. Derevianko. Th e publication of the book is part of the project “Archaeology and Ethnography of the Far Eastern Frontier. International scientifi c conference dedicated to the anniversary of Academician A.P. Derevianko”.
Youth of IAET SB RAS: Archaeology of Siberia: scientific memoirs
Authors:   Institute of Archaeology and Ethnography, Siberian Branch, Russian Academy of Sciences, Mylnikov V.P.
Published: December 2023

The monograph is a continuation of a series of scientifi c memoirs that popularize the achievements of the Siberian school of archaeologists. The history of the development and separation of the Humanitarian Research Department of the Institute of Economics and Organization of Industrial Production SB AS USSR, and then the sector of archaeology of the joint Institute of History, Philology and Philosophy SB AS USSR into a research Institute of Archaeology and Ethnography SB RAS under the leadership of Academician A.P. Okladnikov and his closest students A.P. Derevianko, R.S. Vasilevsky, V.I. Molodin, E.I. Derevianko is covered in detail. The book tells about the most famous and signifi cant sites explored by the Institute staff in the 1960s – early 1990s. The book is addressed to all those who are interested in the fate of Siberian archaeology, but above all to the younger generation of the IAET SB RAS, archaeologists, students of historical departments of universities.
Cultural-Historical Approach to Preschoolers’ Dance Creativity: Problems and Solutions
Authors: Gorshkova E.V.
Published: December 2023

The problems of the theory of dance creativity of preschoolers are analyzed from the standpoint of a cultural and historical approach. As methodological support for the analysis, we used the views of L.S. Vygotsky and his followers on children's artistic creativity, on the nature of dance and dance expressiveness, on the peculiarities of music in dance. Based on this, we analyzed three theoretical approaches to the development of dance creativity of preschoolers, and described their differences and partial mutual influences. The system of provisions of cultural and historical psychology as a methodological basis indicates ways to solve the problems of the theory of dance creativity of preschoolers, which should be figurative and meaningful, thanks to the development of the expressive language of dance, reflecting the features of the musical image and real events, relationships, experiences through the embodiment of different characters.
Variations on the Subject of Developmental Education
Authors: Stepanova M.A.
Published: December 2023

The article raises the problem of developmental teaching (education) from the standpoint of cultural- historical methodology, the origins and scientific foundations of it its basic principles and widespread practical systems. The author’s aim is to discover the general and specific features of existing models of developmental instruction, both theoretical justifications and practical recommendations for the organization of real school education. It is suggested that there is one system of developmental education based on the ideas of L.S.Vygotsky about the correlation between education and mental development and there are various theoretical approaches and practical models based on it. We tried to compare different attitudes to the correlation between education and mental development. We analyzed work made by Galperin, by research teams led by Elkonin and Davydov, and rby esearch teams led by L.V.Zankov. Special attention is paid to Repkin's research on the psychological organization of educational material, it illustrates the interpenetration of two approaches: Galperin's ideas about the developmental effect of instruction and Davydov's theory of learning activity. The author's hypothesis needs a theoretical and experimental verification, which will have not only a narrow scientific value, but also determine the directions of changes in the content of school education in accordance with the psychological laws of assimilation.
Personality Syndromes in the Light of the Historical Crisis in Psychology, a Cultural-Historical Activity Theory Position
Authors: Mohamad E. , Zheng J. , Shi Y.
Published: December 2023

Following the cultural-historical activity theory guidelines, this study investigates the potential consistency between scientific methodologies and personality syndromes. By minding not falling into rough simplification and misleading generalization, our methodological assumption suggests a line of historical similarity worthy of being investigated deeply in future studies. The study looks into the consistency in the historical development of the methodologies representing ‘the symptoms’ of psychology as a science living through its historical crisis, on one hand, and the personality syndromes representing the ‘implicit methodologies’ of individuals, on the other. Such an approach allows one to draw more on personality syndromes, their taxonomy, and their root, in addition to the potential predictions of their destiny. A crucial methodological consideration that allows such dependency is that science is a special form (highly abstract and generalized) of creative activity sharing a similar nature to the daily ordinary creative activity of personality. So, science might represent an early historically elaborated version of the ordinary-daily form of activity structure, which allows us to hypothesize that personality syndromes, in their own characteristics, might share the developmental tendency of the noted methodologies rooted in the subjective-objective epistemological rupture as a ground of the historical crisis.
Repair of Bone Defect of the Talus with Calcaneus Autograft and Autologous Matrix-Induced Chondrogenesis: A Case Report
Authors: Korobushkin Gleb V. , Akhmedov Bagavdin G. , Chebotarev Vitaly V. , Gaidarov Arip R.
Published: December 2023

Background. The question of choosing a treatment strategy for full-thickness osteochondral defects of the tarsal bone remains relevant. When choosing a treatment strategy, two key points should be considered: restoring the architecture of the tarsal bone and achieving long-term restoration of cartilage-like coverage in the area of the osteochondral defect.
Case report. A 34-year-old physically active patient sustained an ankle injury in 2011 and was treated conservatively. In 2020, he complained of pain and reduced activity. Initial assessment scores were: VAS (Visual Analog Scale) — 6 points, AOFAS-AHS (American Orthopaedic Foot and Ankle Society Ankle-Hindfoot Score) — 49 points, FAAM (Foot and Ankle Ability Measure) — 55 points. An MRI revealed an osteochondral defect in the medial part of the tarsal bone dome, measuring 16.4×9.4 mm and with a depth of 20.8 mm. The patient underwent the replacement of the bone defect with an autograft taken from the heel bone, using autologus matrix induced chondrogenesis (AMIC) procedure. After 6 months, a follow-up examination was performed, including ankle arthroscopy and removal of metal fixators. Arthroscopic findings showed that the chondroplasty area was almost identical to intact joint cartilage. One year after chondroplasty, the patient returned to his previous level of physical activity. Assessment scores were: VAS — 1 point, AOFAS-AHS — 94 points, FAAM — 83 points.
Conclusion. The proposed method allows for the restoration of the architecture of the tarsal bone along with the cartilage surface. The use of a bone autograft helps to fill the tarsal bone defect, and covering the autograft with a collagen membrane contributes to the formation of hyaline-like cartilage tissue in the defect area.
Editorial Comment on the Article by A.N. Tsed et al. “Total Knee Arthroplasty in Hemodialysis Patients: Routine or Complex Surgery?”
Authors: Kornilov Nikolai N.
Published: December 2023

Severe comorbidities, like chronic kidney disease, strongly associated with higher risk of complications after total knee arthroplasty. Therefore hemodialysis patients need specific pre-operative as well as peri-operative management, including proper analgesic, antibacterial and thromboembolic pharmacological prophylaxis. Nevertheless the technical issues that surgeon has to solve in achieving proper leg alignment, knee stability and range of motion does not differ from other complex knee primary cases when revision implants and instruments are essential part of surgical requisite.
Ensuring delivery of medical education in conflict-affected nations
Authors: SHRİVASTAVA Saurabh , SHRİVASTAVA Prateek
Published: December 2023

Medical education refers to the process wherein freshly passed school students are transformed into competent healthcare professionals after being subjected to a structured training program. The emergence or continuation of a conflict is expected to interrupt the ongoing civic activity, and is expected to result in the delay, decline, or complete interruption of the training activities and delivery of medical education in the medical institutions. All the above factors and existing realities call for the need to ensure that the process of medical education has to continue even during the conflicts and this essentially will require understanding and mutual agreement between the conflicting stakeholders. To conclude, conflicts have become a part of the current era with millions of people experiencing them. As these conflicts tend to influence each and every sector, even the area of medical education has been significantly affected. However, as most of the affected nations cannot afford the shortage of healthcare providers, there is an indispensable need to continue the training process even during conflicts and expose the medical students to conflict-related curriculum.
A lay association as a client
Authors: Longhi Andrea
Published: December 2023

Research into the Italian Liturgical Movement emphasised the pedagogical commitment of lay associations, rather than architectural innovation they eventually promoted. The case study presented here discusses a little-known case of ambitious architectural patronage promoted in 1952-53 by the main Italian lay association: the Italian Youth of Catholic Action (Gioventù di Azione Cattolica, GiAC). The winning design by architect Enzo Magnani, the first president of the Catholic Union of Italian Artists (UCAI), was rejected directly by Pius XII, probably as an indirect consequence of the worsening of the political fracture between the GiAC and the main branches of the Azione Cattolica, oriented towards explicit support for conservative and clericalist political positions, rather than ecclesial engagment and liturgical afflatus. The archives of Azione Cattolica Italiana (preserved by ISACEM in Rome) and some private archives allow a first reconstruction of the matter, which had been completely erased from the asssociation’s official history, and probably broke any possible link between associative patronage and liturgical architecture during the decades that followed.
Análisis cualitativo femenológico de las finanzas en las empresas de transporte durante la pandemia del Covid-19
Authors: Flores-Quispe Gina Lisseth , Quispe-Chambi Milagros Jhempy , Quispe-Chambi Irma Candy , Cusilayme-Barrantes Helfer Rudel , Sánchéz-Garcés Jorge , Moreno-Leyva Nelly Rosario
Published: December 2023

Investigación cuya finalidad fue demostrar si el Covid-19 influyó en las finanzas de las empresas de transporte interprovincial de una región del sur del Perú. De metodología cualitativa, de técnica fenomenológica y como instrumento aplicado es, la entrevista estructurada y no estructurada. A través del intercambio de opiniones se logró identificar las categorías y subcategorías: el compromiso financiero, problemas y soluciones de liquidez. Los gerentes de las empresas y dueños de las unidades móviles identificaron estrategias como el ahorro de los saldos del dinero recaudado; contar con otras fuentes de ingreso, adquirir un negocio dedicado a otro rubro. Soluciones con respecto a la liquidez de la empresa, de esa manera de forma progresiva puedan cubrir sus gastos sin dificultad.
¿Cuáles son los estilos de aprendizaje, Inteligencia Múltiples y Emocional del estudiantado de primer año de pedagogía en educación física?
Authors: Flores-Ferro Elizabeth , Maureira -Cid Fernando , Cuevas-González Cristián , Vásquez-Herrera Camila
Published: December 2023

El objetivo del presente estudio fue relacionar los estilos de aprendizaje, habilidades emocionales y múltiples con el rendimiento académico en estudiantes de primer año de la carrera pedagogía en educación física de una universidad de Santiago de Chile. Metodología: de tipo cuantitativa, no experimental de corte transversal. La muestra estuvo constituida por 84 estudiantes (20 mujeres y 64 hombres). Para evaluar los estilos de aprendizaje se utilizó CHAEA-36 y el Inventario Herrmann de Dominancia Cerebral, también se aplicó el Inventario de Inteligencias Múltiples (IAMI-R), el Inventario de Inteligencia Emocional y para el rendimiento académico, el acta de notas de las asignaturas cursadas en el primer semestre por el estudiantado. Resultados: se encontraron correlaciones medias bajas entre el estilo de aprendizaje activo con el rendimiento académico (r=-0,235) y la dominancia B se relaciona positivamente con las calificaciones (r=0,270). Conclusiones: son necesarios futuros estudios con un diseño longitudinal y experimental, ya que existen algunas habilidades claves para un docente integral que se debería intervenir desde los primeros años de formación.
Рак коры надпочечников
Authors: Горбунова В. А. , Бельцевич Д. Г. , Бохян В. Ю. , Жуликов Я. А. , Коломейцева А. А. , Мельниченко Г. А. , Феденко А. А.
Published: December 2023

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Почечноклеточный рак
Authors: Волкова М. И. , Алексеев Б. Я. , Гладков О. А. , Матвеев В. Б. , Носов Д. А.
Published: December 2023

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Мукозиты
Authors: Семиглазова Т. Ю. , Беляк Н. П. , Владимирова Л. Ю. , Корниецкая А. Л. , Королева И. А. , Нечаева М. Н. , Раджабова З. А. , Телетаева Г. М. , Ткаченко Е. В.
Published: December 2023

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Role of sex steroid hormone on hand grip strength and cognitive function in the elderly
Authors: Parwanto Edy , Tjahyadi David , Amalia Husnun , Hairunisa Nany , Edy Hosea Jaya , Oladimeji Ashaolu Victoria , Djebli Noureddine
Published: December 2023

The aging process is associated with changes in hormone levels. There is a noticeable change in estrogen levels in women, while in men, there is a change in testosterone levels. In the elderly, as a result of the aging process, changes in these hormone levels affect handgrip strength, and cognitive function. In both women and men, the function of several organs is influenced by sex steroid hormones, namely Oestrogen and androgens. There are two theories of steroid action mechanism on target cells, namely steroid hormone action mechanism genomically and non-genomically. The function and action mechanism of steroid hormone is important because it is the basis of the hormonal aspect for muscle mass, handgrip strength, and cognitive function. Due to the aging process, hormonal changes in the elderly are different compared to the previous period. This has consequences for changes in metabolic processes that affect the body’s condition, including changes in the composition of bones, muscles, and other tissues, such as the brain. In the aging process, it is important to pay attention to nutritional factors because they contribute to hormone levels that help maintain muscle mass, body mass index, hand grip strength, and cognitive function. In the brain, the sex steroid hormone has activating and organizational effects mediated by intracellular or transmembrane G-protein-coupled receptors. Articles published in English in the last 9 years (from 2014 to 2023) were retrieved from Science Direct, PubMed, Springer link, Oxford and Nature using relevant searching terms. The fact that testosterone bioavailability is predominated in the brain in relation to its activity and significant positive association with processing speed, sustained attention, and working memory in older men. To obtain a better quality of life for the elderly, nutritional factors must be considered to maintain optimal sex steroid hormone levels, hand grip strength, and cognitive function.
Finlandiya Kalkınma Politikası ve Kalkınma Ajansları
Authors: İRDEM İbrahim
Published: December 2023

Kalkınma ajansları bölgelerarası ya da bölge içi gelişmişlik farklılıklarını azaltmayı amaçlayan; faaliyet gösterdiği bölgenin ekonomik ve sosyal kalkınmasının güçlendirilmesini hedefleyen, bu nedenle kalkınmaya ilişkin projeleri destekleyen ve kamu, özel sektör ve sivil toplum kuruluşları arasındaki iş birliğini teşvik eden kuruluşlardır. Özellikle kendine münhasır politikalar benimseyen ve önemli bir İskandinav refah devleti örneği teşkil eden Finlandiya’da kalkınma ajansları konusuna yer veren sınırlı sayıda ulusal ve uluslararası akademik çalışma olduğu görülmüştür. Bu nedenle gerek literatüre katkı sağlamak gerekse Finlandiya’da kalkınma ajansları konusunu derinlemesine tahlil etmek için bu çalışmada Finlandiya’nın kalkınma politikasına ve kalkınmadan sorumlu kuruluşlara yer verilmesi amaçlanmıştır. Çalışmanın temel araştırma sorusu Finlandiya’nın kalkınma politikasının ve kalkınma ajanslarının ulusal ve uluslararası kalkınma hedeflerine nasıl katkıda bulunduğudur. Finlandiya kalkınma politikası ve kalkınma ajanslarına dair gerek dil farkı nedeniyle gerekse de iç işleyişe ilişkin bazı verilere tam erişim sağlanamaması çalışmanın sınırlı yönünü oluşturmaktadır. Çalışma metodolojik olarak nitel araştırma yöntemlerinden doküman analizi ve vaka analizi tekniklerine dayanmaktadır.
Irak’taki Bankaların Karlılığını Etkileyen Faktörler
Authors: ÖKSÜZ Sezer , ALI AHMED ALI Imad Mohammed
Published: December 2023

Bankalar güçlü bir ekonomik sistemin en önemli aktörleri arasında yer almakta, makroekonomik olarak ülkenin refah seviyesinde de önemli rol oynamaktadır. Bu nedenle, bankaların finansal performanslarının ölçülmesi ve bu performansa etki eden faktörlerin ortaya konulması ekonomik açıdan büyük önem taşımaktadır. Bu araştırmada, 14 Irak bankasının 2015-2021 yılları arasındaki finansal oranlarının aktif ve özsermaye karlılığı üzerindeki etkisi panel regresyon analizi ile incelenmiştir. Bu kapsamda bağımlı değişken olarak aktif ve özsermaye karlılığı, bağımsız değişkenler olarak da toplam aktiflerin logaritması, borç toplamı/aktif toplam, kredi ve alacaklar/aktif toplam, diğer faaliyet giderleri/aktif toplam, sermaye yeterlilik oranı, toplam mevduat/toplam aktif, faiz gelirleri/faiz giderleri, takipteki krediler/toplam krediler ve likit aktifler/toplam aktif oranları kullanılmıştır. Analiz sonuçlarına göre Irak’taki bankaların aktif ve özsermaye karlılıklarının, bankaların aktif büyüklüğünden, kredi ve alacakların aktif toplamına oranından, mevduatın aktif toplamı içerisindeki payından, sermaye yeterlilik rasyosundan, faiz gelirlerinin faiz giderlerine oranından ve likit aktiflerden etkilendiği belirlenmiştir
Redox regulation of the NLRP3-mediated inflammation and pyroptosis
Authors: Rusetskaya N.Yu. , Loginova N.Yu. , Pokrovskaya E.P. , Chesovskikh Yu.S. , Titova L.E.
Published: December 2023

The review considers modern data on the mechanisms of activation and redox regulation of the NLRP3 inflammasome and gasdermins, as well as the role of selenium in these processes. Activation of the inflammasome and pyroptosis represent an evolutionarily conserved mechanism of the defense against pathogens, described for various types of cells and tissues (macrophages and monocytes, microglial cells and astrocytes, podocytes and parenchymal cells of the kidneys, periodontal tissues, osteoclasts and osteoblasts, as well as cells of the digestive and urogenital systems, etc.). Depending on the characteristics of redox regulation, the participants of NLRP3 inflammation and pyroptosis can be subdivided into 2 groups. Members of the first group block the mitochondrial electron transport chain, promote the formation of reactive oxygen species and the development of oxidative stress. This group includes granzymes, the mitochondrial antiviral signaling protein MAVS, and others. The second group includes thioredoxin interacting protein (TXNIP), erythroid-derived nuclear factor-2 (NRF2), Kelch-like ECH-associated protein 1 (Keap1), ninjurin (Ninj1), scramblase (TMEM16), inflammasome regulatory protein kinase NLRP3 (NEK7), caspase-1, gasdermins GSDM B, D and others. They have redox-sensitive domains and/or cysteine residues subjected to redox regulation, glutathionylation/deglutathionylation or other types of regulation. Suppression of oxidative stress and redox regulation of participants in NLRP3 inflammation and pyroptosis depends on the activity of the antioxidant enzymes glutathione peroxidase (GPX) and thioredoxin reductase (TRXR), containing a selenocysteine residue Sec in the active site. The expression of GPX and TRXR is regulated by NRF2 and depends on the concentration of selenium in the blood. Selenium deficiency causes ineffective translation of the Sec UGA codon, translation termination, and, consequently, synthesis of inactive selenoproteins, which can cause various types of programmed cell death: apoptosis of nerve cells and sperm, necroptosis of erythrocyte precursors, pyroptosis of infected myeloid cells, ferroptosis of T- and B-lymphocytes, kidney and pancreatic cells. In addition, suboptimal selenium concentrations in the blood (0.86 μM or 68 μg/l or less) have a significant impact on expression of more than two hundred and fifty genes as compared to the optimal selenium concentration (1.43 μM or 113 μg/l). Based on the above, we propose to consider blood selenium concentrations as an important parameter of redox homeostasis in the cell. Suboptimal blood selenium concentrations (or selenium deficiency states) should be used for assessment of the risk of developing inflammatory processes.
System analysis of surface CD markers during the process of granulocytic differentiation
Authors: Novikova S.E. , Tolstova T.V. , Soloveva N.A. , Farafonova T.E. , Tikhonova O.V. , Kurbatov L.K. , Rusanov A.L. , Zgoda V.G.
Published: December 2023

Plasma membrane proteins with extracellular-exposed domains are responsible for transduction of extracellular signals into intracellular responses, and their accessibility to therapeutic molecules makes them attractive targets for drug development. In this work, using omics technologies and immunochemical methods, we have studied changes in the content of markers of clusters of differentiation (CD markers) of neutrophils (CD33, CD97, CD54, CD38, CD18, CD11b, CD44, and CD71) at the level of transcripts and proteins in NB4, HL-60 and K562 cell lines, induced by the treatment with all-trans-retinoic acid (ATRA). Transcriptomic analysis revealed the induction of CD38, CD54, CD11b, and CD18 markers as early as 3 h after the addition of the inducer in the ATRA-responsive cell lines HL-60 and NB4. After 24 h, a line-specific expression pattern of CD markers could be observed in all cell lines. Studies of changes in the content of CD antigens by means of flow cytometry and targeted mass spectrometry (MS) gave similar results. The proteomic profile of the surface markers (CD38, CD54, CD11b, and CD18), characteristic of the NB4 and HL-60 lines, reflects different molecular pathways for the implementation of ATRA-induced differentiation of leukemic cells into mature neutrophils.
The effect of hyperglycemia on the activation of peritoneal macrophages of albino rats
Authors: Golyako I.A. , Kuzmin V.S. , Gorbacheva L.R.
Published: December 2023

Hyperglycemia is one of the main damaging factors of diabetes mellitus (DM). The severity of this disease is most clearly manifested under conditions of the inflammatory process. In this work, we have studied the activation features of rat peritoneal macrophages (MPs) under conditions of high glucose concentration in vitro. Comparison of the independent and combined effects of streptozotocin-induced DM and hyperglycemia on proliferation and accumulation of nitrites in the MPs culture medium revealed similarity of their effects. Elevated glucose levels and, to a lesser extent, DM decreased basal proliferation and NO production by MPs in vitro. The use of the protein kinase C (PKC) activator, phorbol ester (PMA), abolished the proinflammatory effect of thrombin on PMs. This suggests the involvement of PKC in the effects of the protease. At the same time, the effect of thrombin on the level of nitrites in the culture medium demonstrates a pronounced dose-dependence, which was not recognized during evaluation of proliferation. Proinflammatory activation of MPs is potentiated by hyperglycemia, one of the main pathological factors of diabetes. Despite the fact that high concentrations of glucose have a significant effect on proliferation and NO production, no statistically significant differences were found between the responses of MPs obtained from healthy animals and from animals with streptozotocin-induced DM. This ratio was observed for all parameters studied in the work, during analysis of cell proliferation and measurement of nitrites in the culture medium. Thus, the results obtained indicate the leading role of elevated glucose levels in the regulation of MPs activation, which is comparable to the effect of DM and even “masks” it.
КУЛЬТУРНОЕ НАСЛЕДИЕ РОССИИ: ВОСПИТАТЕЛЬНЫЙ И ПРОСВЕТИТЕЛЬСКИЙ ПОТЕНЦИАЛ (на примере регионального вуза)
Authors:   Бурятский государственный университет имени Доржи Банзарова, А. Д. Бадмаев
Published: December 2023

В статье, рассматривающей воспитательный и просветительский потенциал объектов культурного наследия, автор ставит цель изучить значение и роль указанных объектов для формирования мировоззренческих представлений личности, формирования ее идентичности, определения ценностных установок и траекторий жизненного пути. В работе представлены основные теоретические позиции для понимания сущности понятия «культурное наследие», в качестве аргументов приводятся мнения ученых, а также анализируется законодательная база, сформированная в России и мире для защиты и охраны объектов мирового культурного наследия. Исследование опирается на опыт организации в Бурятском государственном университете имени Доржи Банзарова музейного объекта, посвященного жизни и деятельности одного из ведущих профессоров университета Ефрема Егоровича Тармаханова. Автор статьи описывает главные объекты музейной экс-позиции и приходит к выводу о том, что данный историко-культурный объект, представляя, безусловно, достойный для подражания пример проживания жизни, посвященной людям, в полной мере выполняет важнейшую образовательную, культурную и гражданскую функцию.
Method of organizing page memory in microelectronic devices
Authors: Теремов И.А. , Проказин М.Р.
Published: December 2023

Предлагается возможный способ организации страничного перепрограммируемого постоянного запоминающего устройства в микроконтроллерной технике. Целью статьи является формирование нового подхода к организации хранения произвольных блоков данных в памяти страничного типа. Применимость данного способа показана экспериментальным методом. В результате исследования сформирован принцип разбиения пространства памяти на сегменты и алгоритмы дефрагментации сегментов.

This article proposes a possible way to organize a page PROM in microcontroller technology. The purpose of the article is to form a new approach to organizing the storage of arbitrary data blocks in page-type memory. The applicability of this method is shown experimentally. As a result of the study, the principle of partitioning the memory space into segments and segment defragmentation algorithms were formed.
The use of software modeling methods for the development of systems of on-board control systems of aircraft
Authors: Алексеев В.И.
Published: December 2023

На основе материалов из открытых информационных источников дан краткий анализ современного состояния использования методов программного моделирования для разработки систем бортовых комплексов управления летательных аппаратов, в частности бортовых вычислительных систем. Разработаны предложения по использованию программной эмуляции бортовой вычислительной системы.

Based on materials from open information sources, a brief analysis of the current state of the use of software modeling methods for the development of on-board control systems of aircraft, in particular on-board computer systems, is given. Proposals for the use of software emulation of the onboard computer system have been developed.
Evaluation of the influence of the relative position of the navigation system on the accuracy of determining the location of an unmanned aerial vehicle
Authors: Мансур Р. , Гасилин А.Г.
Published: December 2023

Приведен анализ расчета геометрического фактора, влияние которого позволяет определить геометрию рабочего созвездия навигационных космических аппаратов при решении задач определения местоположения беспилотного летательного аппарата. Необходимость повышения точности навигации неизбежно ведет к наращиванию орбитальной группировки спутниковых навигационных систем, например ГЛОНАСС. Показано, что геометрический фактор имеет значительное влияние на стандартное отклонение навигационной ошибки, и с увеличением его значения ошибка увеличивается. В статье затрагивается тема оптимальных значений факторов DOPs. Представлен метод определения лучшего значения геометрического фактора. Предложенный метод может быть использован в комплексах управления беспилотным летательным аппаратом.

The sequence of formation of formulas of the geometric factor, the influence of which determines the geometry of the working constellation of navigation spacecraft in solving problems of determining the location of an unmanned aerial vehicle, is carried out. The need to solve the problem of increasing the accuracy of navigation inevitably leads to an increase in the GLONASS orbital constellation. It is shown that the geometric factor has a significant effect on the standard deviation of the navigation error, and with an increase in its value, the error increases. A method for determining the best value of the geometric factor is presented. The proposed method can be used in the control complex of an unmanned aerial vehicle.
Kızılçam odununun su yalıtım performansının termal biyo-yağ daldırma tekniğiyle iyileştirilmesi
Authors: VAR Ahmet Ali
Published: December 2023

Kızılçam (Pinus brutia Ten.) odununun su yalıtım performansının termal biyo-yağ daldırma tekniğiyle iyileştirilmesinin amaçlandığı bu çalışmada hint yağı (Ricinus communis L.), keten yağı (Oleum linii), karma yağ (%50 hint yağı / %50 keten yağı) ve termal metot (sıcak-soğuk daldırma yöntemi) kullanılmıştır. Odun örnekler üzerinde retensiyon miktarı ile su alma oranı, su itici etkinlik ve hacimsel genişleme özellikleri belirlenmiştir. Yağlar arasında en yüksek retensiyon miktarı keten yağı ile emprenyeli odun örneklerinde %42.90 olarak elde edilmiştir. Emprenyeli örneklerin su alma oranı değerleri kontrol örneklerindekinden daha düşük bulunmuştur. En düşük su alma oranı değeri keten yağı ile muamele edilen örneklerde %19.20 olarak ölçülmüştür. Su itici etkinlik için, keten yağı muamelesi, hint yağı ve karma yağ muamelelerinden daha iyi sonuçlar vermiştir. Emprenyeli örnekler önemli bir hidrofobik özellik göstermiştir. Her üç yağ için, işlem gören örneklerin hacimsel genişleme değerleri kontroldekinden daha düşük bulunmuştur. Tüm bunlar, sıcak-soğuk bio-yağ daldırma tekniğinin sözkonusu fiziksel özelliklerine pozitif etkiler yaparak hidrofobik-su itici nitelik kazandırılan kızılçam odununun su yalıtım performansını önemli düzeyde iyileştirdiği sonucunu ortaya koymaktadır. Bu sonuçlara göre, kızılçam odunu için, su/rutubet etkisine maruz ortamlarda, kullanım öncesi termal biyo-yağ daldırma işleminin uygulanması faydalı olacaktır. Bu bağlamda, iç mekân kullanımlarda su yalıtımlı nihai ağaç malzeme üretiminde kızılçam diri odununun termal biyo-yağ daldırma prosesiyle kullanılması önerilebilir.
Korunan alanlarda sürdürülebilir yönetim etkinlik düzeyinin belirlenmesi: Milli parklar örneği
Authors: BİNBOĞA Gül , DAŞDEMİR İsmet
Published: December 2023

Korunan alanlarda koruma-kullanma dengesi sağlanarak yönetim etkinliğinin sürekli olarak değerlendirilmesi ve iyileştirici önlemlerin alınması sürdürülebilir bir yönetim için gereklidir. Bu çalışmanın amacı Türkiye’deki korunan alanların yönetim etkinlik düzeyinin belirlemek ve değerlendirmektir. Çalışmada örnek alan olarak Ege Bölgesindeki Spil Dağı Milli Parkı, Dilek Yarımadası-Büyük Menderes Deltası Milli Parkı ve Marmaris Milli Parkı seçilmiştir. Söz konusu alanların yönetim etkinlik düzeyinin belirlenmesinde küresel düzeyde yaygın olarak uygulanan araçlardan Yönetim Etkinliğini İzleme Aracı (METT-4) kullanılmıştır. Her üç milli parkın uzun devreli gelişme planları, yöneticiler ile yapılan görüşmeler ve METT-4 uygulamasından elde edilen veriler bu araştırmanın materyalini oluşturmaktadır. METT-4’ün uygulanmasında alanların bizzat yönetimlerinden sorumlu Milli Park Müdürleri, Milli Park Müdür Yardımcıları ve Milli Park Şeflerinin görüşlerine yer verilmiştir. Elde edilen veriler çizelgeler ile gösterilmiş ve verilerin değerlendirilmesinde yüzde hesaplamaları ile ortalamadan yararlanılmıştır. Yapılan değerlendirmeler neticesinde, Spil Dağı Milli Parkının yönetim etkinlik düzeyi %58 (orta düzeyde), Dilek Yarımadası-Büyük Menderes Deltası Milli Parkının %63 (iyi düzeyde) ve Marmaris Milli Parkının %48 (orta düzeyde) olarak bulunmuştur. Üç milli parkın yönetim etkinlik düzeyinin aritmetik ortalaması ise %56 olup, orta düzeyde bir etkinliği göstermektedir. Söz konusu alanlarda yönetim etkinliği değerlendirme unsurlarından Planlamanın ortalaması %70’lik düzeyle en iyi durumda iken, Girdiler (%59), Süreçler (%52), Çıktılar (%62) ve Sonuçlarda (%42) daha düşük bir etkinlik düzeyi olduğu belirlenmiştir. Dolayısıyla bu çalışmaya konu olan korunan alanların yönetim etkinlik düzeyinin yeterli olmadığı söylenebilir. Bu sonuçta başta yeterli sayıda ve nitelikte personel yetersizliği olmak üzere mevzuat, bütçe/finansman, koordinasyon gibi birçok konuda yaşanan yetersizliklerin etkili olduğu saptanmıştır. Sonuç olarak, Türkiye’deki korunan alanların sürdürülebilir yönetimini sağlamak amacıyla yönetim etkinlik düzeyinin artırılması ve mevcut sorunların çözümü için gerekli çalışmaların kararlılıkla yapılması gerektiği belirlenmiştir.
Orman sertifikasyonu değerlendirme süreçleri ve sürdürülebilir orman yönetimine etkileri
Authors: AYDIN Yunus , AKYOL Ayhan
Published: December 2023

Ormancılıkta sertifikasyon çalışmaları, orman yönetim sertifikası ve orman ürünleri sertifikası olarak iki ayrı bölümden oluşmaktadır. Özellikle orman ürünleri sertifikası almanın ön şartı orman yönetim sertifikasına sahip ormanlardan elde edilen ürünlerin kullanılması gerekliliğidir. Bu çalışmada, Milas Orman İşletme Müdürlüğü’nün orman sertifikasyonu başvuru süreci ve Forest Stewardship Council tarafından gerçekleştirilen ön ve ara değerlendirme verileri analiz edilerek değerlendirilmiştir. Araştırmada iki aşamalı bir veri toplama süreci izlenmiştir. Birincisi; literatür taraması yoluyla çalışma için gerekli kaynakların ve dokümanların toplanmasıdır. İkincisi; arazi uygulamaları ve gözlemleridir. Verilerin analizinde ise doküman/metin analizi yöntemi kullanılmıştır. Sonuç olarak, sertifikasyon sürecinin Milas ormanlarına, orman idaresine ve yörede yaşayan halka, ekolojik, ekonomik, sosyal ve yönetsel yönlerden olumlu katkılar sağladığı belirlenmiştir. Ayrıca, ön değerlendirme çalışmalarının ana değerlendirme öncesinde işletmeye önemli avantajlar sağladığı ve sürecinin başarı ile sonuçlanmasına katkı sağladığı tespit edilmiştir. Buna göre iyi yönetilen bir sertifikasyon sürecinin, sürdürülebilir orman yönetimi açısından orman idaresine, zayıf yönlerini görebilme, düzeltebilme ve sonuçlarını izleyebilme fırsatı verdiği söylenebilir.
POPULARIZAÇÃO E DEMOCRATIZAÇÃO DA INTELIGÊNCIA ARTIFICIAL NO NORDESTE BRASILEIRO: UM RELATO DE EXPERIÊNCIA
Authors: Cabral Luciano De Souza , Lira Rodrigo , Roger Paulo , Neto Antônio , Neto Josino , Oliveira Flavio , Cartaxo Bruno , Sabino Eduardo , Beltrão Tatiana
Published: December 2023

Este artigo explora a popularização e democratização da Inteligência Artificial (IA) através de um curso de IA na região N­ordeste do Brasil. O objetivo é avaliar o ensino atual de IA na região e propor estratégias para tornar o conhecimento de IA mais acessível. A pesquisa analisa a infraestrutura educacional existente e identifica desafios e oportunidades específicas da região Nordeste. O estudo visa preencher a lacuna entre a demanda por habilidades de IA e as oportunidades de aprendizado. O documento investiga os benefícios potenciais do curso de IA, como a melhoria das perspectivas de carreira, o estímulo à inovação e a capacitação de indivíduos e empresas no uso eficaz da IA. Também destaca a importância de abordar considerações sociais e éticas no ensino de IA para garantir uma abordagem responsável e inclusiva. Ao promover a popularização e democratização da IA no Nordeste brasileiro, a experiência contribui para o avanço tecnológico, o crescimento econômico e o progresso social da região na era da IA.
Complex of algorithms for fast determination of the parameters of motion of high-speed vessels in the digital signal processing system of a space synthetic aperture radar
Authors: Gusev S. N. , Moroz A. V.
Published: December 2023

The article presents the main considerations for determining the tangential velocity of high-speed vessels in the digital signal processing system of a space synthetic aperture radar with an amplitude-phase program discriminator in the azimuth channel. The article suggests a complex of algorithms for fast determination of the parameters of motion of high-speed vessels in the digital signal processing system of a space synthetic aperture radar. The article contains the results of semi-natural experiments that confirm the reliability of the algorithms and their effectiveness in solving the problem of observing the sea surface.
Power plants of the first aircraft
Authors: Drygin A. S.
Published: December 2023

The article is dedicated to the 140th anniversary of the construction of the first Russian aircraft designed by Alexander Fedorovich Mozhaisky. The main attention is paid to a comparative assessment of the parameters of the power plants of the Mozhaisky aircraft and some of the best known of the first heavier-than-air manned aircraft driven by a propeller. For the analysis, data published in various sources were used, primarily on the parameters of the elements of power plants (engines and propellers). An assessment was made of the sufficiency of the engine power of the first aircraft needed for their flight. The published materials of detailed studies of the aerodynamics of aircraft by A.F.Mozhaisky and the Wright brothers were used as the basis for an expert qualitative assessment of the aerodynamic characteristics of the compared aircraft. An analysis of the known statistical data and the results of the calculated estimates made it possible to show the impact of engine improvement on the progress in aviation.
JSC “ODK” experience in implementing digital twin technologies in the design of gas turbine engines
Authors: Vinogradov K. A. , Nikulin A. S. , Shmotin Yu. N.
Published: December 2023

The prerequisites for the formation, basic principles and approaches of the GTE design technology used in JSC “UEC” based on the concept of “digital twin” are considered. The components of the DT technology are fixed, three types of computer models included in the perimeter of the digital twin: models “as designed”, “as manufactured”, “as tested”, are considered. The necessity for constructing automated computational chains is noted and a brief description of the process is given.
Powszechność wiary a niemoralni wierzący
Authors: Biłgorajski Piotr
Published: December 2023

Z wielu kwestii, które Jacek Wojtysiak podjął w swojej nowej książce Między ukryciem a jawnością (2023), na szczególną uwagę zasługuje polemika z Johnem L. Schellenbergiem, dotycząca problemu Bożej ukrytości. J.L. Schellenberg w pomysłowy sposób chce pokazać, że samo istnienie ateistów wystawia na próbę prawdziwość tezy o istnieniu osobowego Boga. W odpowiedzi Wojtysiak odwraca argument J.L. Schellenberga, twierdząc, że powszechność wiary wystawia na próbę przekonanie ateisty. Celem artykułu jest wykazanie, że tak jak właściwym wnioskiem argumentu J.L. Schellenberga nie jest teza ateistyczna, tak samo argument J. Wojtysiaka tak naprawdę nie broni teizmu. O obu argumentach należałoby raczej powiedzieć, że są to rozumowania, które wspierają ultymizm.
Artykuł składa się z trzech części. W pierwszej przedstawiam argument J.L. Schellenberga z „Bożej ukrytości” oraz rekonstruuję argumentację J. Wojtysiaka z „wielkiego faktu wiary”. W drugiej części próbuję pokazać, że istnienie niemoralnych wierzących podważa tezę o powszechności wiary w teistycznego Boga. W trzeciej części przedstawiam oba argumenty jako wspierające tezę ultymizmu.