bluuebunny/crossref_metadata_2025 huggingface dataset:
Pharmacognostic characterization and antibacterial activity of Brugmansia suaveolens (Humb. & Bonpl. ex Willd.) Bercht. & J. Presl leaves: A traditional Himalayan medicinal plant
Authors: Sharma Shubham , Kalia Pankaj , Palsra Kalpna , Attri Tushar , Khan Huma , Kapoor Vijay Kumar , Pundir Swati
Published: October 2023

BACKGROUND:

Brugmansia suaveolens (Humb. & Bonpl. ex Willd.) Bercht. & J. Presl (synonym Brugmansia arborea; family Solanaceae) is one of the total seven species of Brugmansia which is commonly known as angel’s trumpet. It has analgesic, antinociceptive, anticancer, anti-inflammatory, antiasthmatic, and various other activities. Despite its numerous medicinal properties, it has never been explored for its potential against bacterial species; also, no publication has been made on pharmacognostical characterization and high-performance thin layer chromatography (HPTLC) investigation of its leaves.

OBJECTIVE:

The aim of this article is to evaluate the pharmacognostical, physicochemical, HPTLC profiles of B. suaveolens leaves along with the assessment of in-vitro antibacterial activity of its various fractions.

MATERIALS AND METHODS:

B. suaveolens collected from sub-Himalayan region of Himachal Pradesh, India was authenticated and then studied for various pharmacognostic and physicochemical parameters employing proper quality control methods for medicinal plant materials designed by the WHO. Extracts and fractions of air-dried coarse plant powder were prepared and were identified for the presence of various classes of compounds using preliminary phytochemical screening. HPTLC profile for quantitative evaluation of atropine in leaves of B. suaveolens was carried out and lastly, fractions were assessed for antibacterial activity by using disc diffusion method against chloramphenicol as standard.

RESULTS:

Transverse section, powder microscopy, leaf constants, and physicochemical parameters revealed valuable data to set up standards for the plant. Alkaloids, glycosides, flavonoids, steroids, triterpenoids, and carbohydrates were found to be present. HPTLC showed 7.79–13.20%w/w of atropine in the plant. Chloroform and ethyl acetate fraction showed encouraging results against four strains of Gram-negative bacteria with good zone of inhibitions.

CONCLUSION:

The present study provides referential information for identification, authentication, and standardization of this highly important crude drug.
Standard manufacturing procedure of Yava kshara (alkali preparation from Hordeum vulgare L.) with cotton wick method
Authors: Aggarwal Punam , Galib R. , Prajapati Pradeep Kumar
Published: October 2023

Background:

Ayurveda deals with minerals, metals, and herbs in therapeutics that have been classified into several groups. Among them, Yava kshara (alkali preparation made with the whole plant of barley (Hordeum vulgare L.) is a type of Kshara (alkaline preparation) that is useful in various diseases. Addition of cotton wick in the procedure seems to facilitate the process and increase the yield. However, its actual utility is not yet reported.

Objective:

The aim of this study was to develop a standard manufacturing procedure (SMP) of Yava kshara by using the cotton wick method.

Materials and Methods:

The method of Ayurvedic Pharmacopoeia of India was followed with addition of cotton wick to decant the liquid layers. Yava panchanga (whole plant—root, stem, leaf, flower, and seed of H. vulgare L.) was collected from the fields of Derwala, Jhunjhunu, Rajasthan and authenticated at the National Institute of Science Communication and Information Resources (NISCAIR), New Delhi. Plant was dried and converted into ashes, washed for three times, and the process of decantation by cotton wick method was repeated to obtain alkaline preparation.

Results:

An average of 11.72% w/w Yava kshara was obtained from the first filtrate. The second and third filtrates yielded 2.9% and 1.26%, respectively.

Conclusion:

Addition of cotton wick facilitates decanting process and obtaining clear liquids. The yield is comparatively higher than the earlier reports.
Critical review on pharmaceutico-analytical and safety profile of Swarna Makshika Bhasma (chalcopyrite calx)
Authors: Meena Vandana , Bhushan Shakti , Chaudhary Anand
Published: October 2023

Swarna Makshika (chalcopyrite), an ore of copper, is used since ancient days in India to treat various ailments. Swarna Makshika Bhasma (SMB) preparation involves two main processes: Shodhana (detoxification) and Marana (incineration in a controlled manner). The present study is designed to compile and assess all the relevant and standard work done related to SMB preparation in addition to standardization in terms of its pharmaceutical, analytical, and safety parameters. These drugs may accumulate contaminants at various stages of manufacturing, transit, and storage, making them dangerous to administer and necessitating their detection and quantification. Analytical instrumentation and procedures are crucial in this regard. Sophisticated analytical analysis (X-ray diffraction, energy dispersive X-ray, Raman spectroscopy, Fourier-transform infrared spectroscopy, scanning electron microscope, transmission electron microscope, and nuclear magnetic resonance) may improvize our understanding on drugs’ overall response in terms of their structure, behavior, and response in the body. Relevant literatures of ancient India related to ayurvedic pharmaceutics for preparation of SMB along with contemporary research databases such as Scopus, PubMed, and various other appropriate contents on the internet were thoroughly searched. This work may provide an insight into its potential effect in characterization and therapeutics, eventually leading to the betterment of human life. Though this compilation has some limitations due to less standard works available, the concise perimeter may provide further quality studies to be done in near future.
Documentation of ethnomedicine used for livestock health care in Kalaburagi district, Karnataka
Authors: Rathod Manjula A. , Mathad Pratima
Published: October 2023

AIM:

This work was designed to undertake documentation and explore ethnomedicine for the treatment of livestock’s health care in Kalaburagi through an ethnobotanical survey.

MATERIALS AND METHODS:

The documentation of ethnomedicine was recorded through ethnobotanical survey by conducting field trips from April 2015 to March 2018 in different Thanda and villages of Kalaburagi district, Karnataka. During the survey traditional practitioners, elderly people, livestock owners, formers, and headman of different Thanda and villages were interviewed for the responses regarding ethnomedicine practices.

RESULTS:

A total 71 of flowering plants from 41 families and 68 genera were involved in the treatment of common livestock’ ailments such as maggot wounds, cuts and wounds, microbial infections, inflammation, bone fracture, gout, joints pain, arthritis, skin diseases, itching, kidney disorders, acidity, cough and cold, throat infection, indigestion, dysentery, bloat, lack of appetite, stomach problems, intestinal worms, foot and mouth disease, weakness and animal bites. The leaves were mostly used in treatment followed by fruits, seeds, root, stem, bark, rhizome, flower, bulb, latex, and whole plant, respectively. The oral administration of juice, decoction, raw, and powder was either given singly or mixed with water, milk, curd, oil, ghee, and honey, whereas pastes of some plant parts were locally applied.

CONCLUSION:

The ethnobotanical survey showed considerable diversity of ethnomedicine used for livestock health care. It was important to explore sustainable use of natural resources for human as well as animal health care, as they are abundantly available in nature in the form of medicinal plants. Obtained data were compared with available literature of different regions of Karnataka and it was observed that many of these uses were not recorded earlier. This study will be helpful to explore more therapeutic uses of plants for livestock’s and may provide a lead in the novel herbal remedies.
Pharmacological activity of Ayurveda herbal medicines in anxiety and depression
Authors: Sonani Snehal , Dudhamal Tukaram S.
Published: October 2023

Research area of herbal psychopharmacology has been increased in this era. It is demand of the era to have comprehensive review of preclinical studies of Ayurveda herbal drugs as antidepressant, anxiolytic, and hypnotic psychopharmacology. On the basis of these findings, further clinical uses as well as better understanding of its mode of action and dosage form can be planned. In this review, search engines such as Ayush Portal, PubMed, DHARA, Research Gate, Scopus, AYU, Google Scholar, Academia, and Google were used to find out widely used psychotropic herbal medicines (last 20 years). A review was conducted to determine mechanisms of action of those drugs, in addition to a scientific review of preclinical trials for the treatment of most common psychiatric clinical conditions, i.e., anxiety and depression. Specific prominence was given to most apparent herbal medicines. Neurochemical as well as epigenetic activities were evident by results of individual herbal medicines in this review. Some drugs were found to be more effective in psychotropic activity, i.e., Kava (Piper methysticum G. Forst.) and Klamath Weed (Hypericum perforatum L.) for anxiety and depression disorders, respectively. However, because many researches have not been produced, caution should be exercised when interpreting the findings.
Seasonal assessment of asiaticoside content in Centella asiatica (L.) Urb. by HPLC and pharmacognostical studies to establish its best procurement time
Authors: Narasimhaji Ch. Venkata , Mangal Anupam K. , Rekha P. , Ilavarasan R. , Srikanth Narayanam
Published: October 2023

BACKGROUND:

This study was designed to validate the collection time for the whole plant of Mandookparni [Centella asiatica (L.) Urb.] by assessing the variation in marker compound asiaticoside, a bioactive secondary metabolite with quantitative high performance liquid chromatography in all available seasons along with the observation of morphological and microscopic studies.

METHODS:

Centella asiatica (L.) Urb. the whole plant was collected from the same habitat in all six seasons described in Ayurveda that is Shishir ritu (Jan–Feb), Vasant ritu (Mar-Apr), Grishm ritu (May-Jun), Varsha ritu (July-Aug), Sharad ritu (Sep-Oct), and Hemant ritu (Nov–Dec). The source of collected plant material was authenticated at Central Ayurveda Research Institute (CARI), Jhansi. The voucher specimen was deposited in the CARI herbarium (Accession no. 23602) for future reference. Botanical identification and comparative macro and microscopic studies for samples collected in each season were carried out. The extraction in various solvents such as alcohol, hydro alcohol, and methanol through soxhlet was carried out to evaluate the quantitative analysis of extractive values and asiaticoside in all six seasons through HPLC at Captain Srinivasa Murthy Central Ayurveda Research Institute (CSMCARI), Chennai.

RESULTS:

The whole plant is used for medicinal purpose. It was observed that the flowering and fruiting occur at end of the rainy (Varsha ritu) season and persists up to the winter season (Shishir ritu). Plant material is procured from the same habitat in all seasons from Central Ayurveda Research Institute (CARI) garden, Jhansi. The raw botanical material showed the similar characters in powder microscopy in Shishir ritu, Vasant ritu, Sharad ritu, and Hemant ritu whereas the powder study of Grishma ritu and Varsha ritu was observed without the fruiting parts that is pericarp and endosperm. And other four seasons are same as Shishir ritu. Selected marker compound asiaticoside was quantified in all available seasons by HPLC. The extractive value was found maximum of 2.2332 g (44.66% w/w) in a methanol extract of Grishma ritu sample and HPLC estimation evident for the large quantity of asiaticoside is more upto 0.4596 (% w/w) in Grishma ritu sample.

CONCLUSION:

The highest concentration of asiaticoside was found in the sample collected during Grishma ritu (May and June). Hence, it can be concluded that the best procurement time for Mandukaparni whole plant is Grishma ritu (May and June).
Accuracy of models of partially edentulous arches obtained by three-dimensional printing: An in vitro study
Authors: Curinga Míria Rafaelli Souza , de Sousa Lucas Cavalcante , Pereira Ana Larisse Carneiro , Segundo Henrique Vieira de Melo , Dantas Lucas Medeiros Cunha Maciel , Carreiro Adriana da Fonte Porto
Published: October 2023

Aim:

The aim of this study was to evaluate the accuracy of models of partially edentulous arches obtained by three-dimensional (3D) printing.

Settings and Design:

This was an in vitro study.

Materials and Methods:

Fifteen partially edentulous models were evaluated, using two methods of measuring dimensions: virtual, using the Standard Tessellation Language files of the models and software (control group), and physical, through printing the models and digital caliper (test group). For both methods, measurements were made regarding the dimensions of the teeth (width and length – buccal/lingual or palatal/occlusal) and distances between the teeth.

Statistical Analysis Used:

For the variable of linear measurements (width and length) and distances between teeth of the same hemiarch, the Wilcoxon test was used, while for the variable between opposite hemiarches, the paired t-test was used.

Results:

In the evaluation of the linear measurements, a significant difference was observed only when the width of the molar tooth was analyzed (P = 0.014). When the buccal length was measured, all teeth had linear measurements provided by the virtual method that was lower than the physical (P = 0.000), as well as the lingual/palatal length in incisors (P = 0.003) and molars (P = 0.009) and in total (P = 0.001). As for the analyses between teeth, no difference was identified between the measurements provided by the virtual method compared to the physical one.

Conclusions:

The 3D printer used to print partially edentulous models provided linear distortions in the teeth but without changes in the distances between teeth of the same hemiarch and between teeth of opposite hemiarches.
Infinite families of Artin–Schreier function fields with any prescribed class group rank
Authors: Yoo Jinjoo , Lee Yoonjin
Published: October 2023

We study the Galois module structure of the class groups of the Artin–Schreier extensions K over k of extension degree p, where
$k:={\mathbb F}_q(T)$
is the rational function field and p is a prime number. The structure of the p-part
$Cl_K(p)$
of the ideal class group of K as a finite G-module is determined by the invariant
${\lambda }_n$
, where
$G:=\operatorname {\mathrm {Gal}}(K/k)=\langle {\sigma } \rangle $
is the Galois group of K over k, and
${\lambda }_n = \dim _{{\mathbb F}_p}(Cl_K(p)^{({\sigma }-1)^{n-1}}/Cl_K(p)^{({\sigma }-1)^{n}})$
. We find infinite families of the Artin–Schreier extensions over k whose ideal class groups have guaranteed prescribed
${\lambda }_n$
-rank for
$1 \leq n \leq 3$
. We find an algorithm for computing
${\lambda }_3$
-rank of
$Cl_K(p)$
. Using this algorithm, for a given integer
$t \ge 2$
, we get infinite families of the Artin–Schreier extensions over k whose
${\lambda }_1$
-rank is t,
${\lambda }_2$
-rank is
$t-1$
, and
${\lambda }_3$
-rank is
$t-2$
. In particular, in the case where
$p=2$
, for a given positive integer
$t \ge 2$
, we obtain an infinite family of the Artin–Schreier quadratic extensions over k whose
$2$
-class group rank (resp.
$2^2$
-class group rank and
$2^3$
-class group rank) is exactly t (resp.
$t-1$
and
$t-2$
). Furthermore, we also obtain a similar result on the
$2^n$
-ranks of the divisor class groups of the Artin–Schreier quadratic extensions over k.
“La Virgen de la silla” de la colegiata de Lerma. Una pintura de oro y seda para la magnificencia ducal
Authors: Sama García Antonio
Published: October 2023

La actual parroquia de san Pedro de Lerma (Burgos), antigua iglesia colegial, todavía conserva un conjunto suntuario de extraordinaria riqueza vinculado a la magnificencia y ostentación del patrocinador del templo, Francisco de Sandoval y Rojas, I duque de Lerma (1533-1625). Entre las obras de este conjunto figura un finísimo tapiz fabricado en seda y oro que ilustra perfectamente el concepto de mecenazgo áulico propiciado por quien fuera gran valido de Felipe III. Se trata de una versión tejida de la pintura original de Rafael Sanzio conocida como La Madonna della seggiola. Según los resultados del trabajo de investigación llevado a cabo, todo invita a pensar que se trata de uno de los cinco paños tejidos en la manufactura ducal de Florencia entre 1599 y 1602 a partir de la composición de Rafael, bajo la dirección de Guasparri Papini.

ini.
Tapices flamencos que Alfonso Pérez de Guzmán (1549-1615) VII duque de Medina Sidonia, llevó a Milán cuando es nombrado Gobernador y Capitán General en el año 1581
Authors: García Calvo Margarita
Published: October 2023

Cuando los duques de Medina Sidonia eran nombrados Gobernadores y Capitanes Generales de Milán por los sucesivos reyes, iniciaban un viaje desde su palacio de Sanlúcar de Barrameda hasta Milán, llevando con ellos no solo a sus sirvientes sino también sus mejores joyas, objetos de plata y tapices. El archivo de la Fundación Medina Sidonia contiene abundante documentación inédita sobre estos viajes. Un ejemplo es el del VII duque en el año 1581.
A rare case of Noonan syndrome associated with biallelic variants
in the LZTR1
Authors: Gandaeva Leila A. , Kaverina Valentina G. , Basargina Elena N. , Pushkov Alexander A. , Savostyanov Kirill V.
Published: October 2023

Introduction. Noonan syndrome is a clinically and genetically heterogeneous disease with multiple organ involvement associated with mutations in the genes of the RAS/MAPK signalling pathway. Most patients with Noonan syndrom (up to 50–80%) have disorders of the cardiovascular system, presented by a wide range of congenital heart defects and/or cardiomyopathy, predominantly hypertrophic phenotype. Thanks to the introduction of high-throughput sequencing, knowledge of the genetic causes of Noonan syndrome has expanded significantly, so since 2014, the LZTR1 gene (OMIM 601247) has been included in the list of genes responsible for the development of Noonan syndrome. The nucleotide variants of this gene are known to be inherited both in an autosomal dominant and autosomal recessive manner. However, the number of reports describing the clinical and genetic characteristics of patients with LZTR1 gene mutations is scarce in the world scientific literature.
Objective. To describe the clinical features of Noonan syndrome with an autosomal recessive type of inheritance caused by biallelic variants c.1259A>G (p.Q420R) and c.2051T>C (p.I684T) in the LZTR1 gene.
Materials and methods. A detailed analysis of the history data, the results of clinical, laboratory, and instrumental studies, a molecular genetic study using high-throughput sequencing technology and direct Sanger sequencing was carried out. After verifying the biallelic variants in the proband, a search was made for the identified nucleotide substitutions in the venous blood samples of the parents and sibs.
Results. The article presents the data of a clinical observation of a rare case of Noonan syndrome caused by pathogenic variants in the LZTR1 gene with an autosomal recessive type of inheritance by the Department of Cardiology of the National Medical Research Center for Children’s Health of the Ministry of Health of Russia.
Conclusion. The diversity of clinical manifestations makes it difficult to diagnose Noonan syndrome based on phenotype alone. The possibility of using high-throughput sequencing improves the quality of diagnostics, contributes to the replenishment of data on new pathogenic variants and the establishment of genotype-phenotypic correlations.
Venous malformation as a rare cause of sciatic neuropathy
Authors: Druzhinina Evgeniya S. , Isaev Igor V. , Kostylev Fedor A. , Narbutov Anton G. , Zavadenko Nikolay N.
Published: October 2023

Sciatic neuropathy is rare and difficult to diagnose in pediatrics and often associated with difficult to control neuropathic pain. The most common causes of sciatic nerve damage in children include trauma and iatrogenic lesions, less often the cause is tumor and vascular formations, among which intraneural venous malformations are the rarest. We present a clinical case of a 13-year boy suffered from right sciatic pain neuropathy with unexpressed neuropathic pain syndrome, asymmetry of the feet, scant impairment of motor and sensory function of the limb for five years, which changed the gait. Neurophysiological testing showed possible location of the process, an asymmetry of sensory and motor responses when testing the nerves of the legs, and abnormal EMG in sciatic-innervated muscles. The magnetic resonance imaging (MRI) showed focal enlargement of the right sciatic nerve in the pelvic region with enhancement upon administration of contrast. Due to the presence of pain in the limb and its forced position — bent at the knee joint, surgical treatment — endoneural neurolysis in combination with targeted therapy by immunosuppressant, was chosen as a therapeutic strategy. The histological study of the intraneural formation confirmed the presence of a venous malformation (VM) in the form of heterogeneous thick– and thin-walled vascular cavities by the presence of fibrosis and lymphocytic infiltration. The result of the treatment was the relief of neuropathic pain syndrome and the recovering of the child gait.
Corporate Political Activities and Political Environments in International Business
Authors: Reithofer Evelyn
Published: October 2023

This article summarizes my dissertation on corporate political activities and political institutional environments in international business. It addresses how firms are affected by random (crisis), regular (election), and firm-induced changes in their political environment. The three key findings of my dissertation are that internal and external institutional pressures are not independent of each other; firms´ international and national diversification act as safeguards when political events occur; and non-pivotal corporate political activities are oftentimes underestimated. In its entirety, the dissertation not only sheds light on various political challenges, but also on firms’ strategies in addressing those challenges.
KAMPUS MENGAJAR ANGKATAN 4: MENUJU INDONESIA CERDAS MELALUI KEGIATAN LITERASI, NUMERASI, ADAPTASI TEKNOLOGI DAN ADMINISTRASI DI SD NEGERI 105357 CEMARA, LUBUK PAKAM
Authors:   Universitas Methodist Indonesia, Saragih Rintan , Lumbantoruan Indriani ,   Universitas Negeri Medan, Ambarita Dastin Bastian ,   Universitas Sari Mutiara Indonesia, Putri Dea Nirwanda ,   Universitas Muslim Nusantara Al-Washliyah, Turnip Novia Magdalena ,   Universitas Prima Indonesia, Silalahi Putri Isabella ,   Universitas Katolik St.Thomas
Published: October 2023

Kampus Mengajar is one of the Merdeka Belajar Kampus Merdeka (MBKM) programs launched by the Ministry of Education, Culture, Research and Technology and supported by the Education Fund Management Institution (LPDP) of the Ministry of Finance. This programe is part of the teaching at schools specially to help students in ellmentary school to assist learning during a pandemic in the 3 areas, whisc is Disadvantaged, Frontier, Outermost by presenting college students as part of strengthening literacy and numeracy. They become a teacher partner in carrying out creativity and innovation in learning. This activity started on 02 August 2022 to 05 December 2022 with the target school SD Negeri 105357 Cemara, Lubuk Pakam, Deli Serdang Regency. Based on the results of the initial mapping, information was obtained that some students could not read and count properly and correctly and had low interest in reading. In addition, the development of soft skills is also needed in the school. Through this activity it is hoped that the school, especially students, can be assisted in terms of increasing numeracy literacy, technology adaptation and administration.
PELATIHAN PEMASARAN ONLINE BERBASIS DIGITAL UNTUK MENINGKATKAN PENJUALAN BISNIS ONLINE PADA UMKM KHAS COLLECTION DI DESA KARANGSARI KECAMATAN KARANGANYAR KABUPATEN PEKALONGAN
Authors:   UIN K.H. Abdurrahman Wahid Pekalongan, Amelia Fitri Virdha , Wulandari Ayu , Wati Vatika Dara , Fidela Syahda , Adinugra Hendri Hermawan
Published: October 2023

Increasing the sales of a product can be done in various ways, one of which is by utilizing online sites found on gadgets. However, not all entrepreneurs, including MSMEs, understand the management of online sites on gadgets, especially for MSMEs located in villages. One of these villages is Karangsari Village in the Khas Collection UMKM. Through online-based marketing training, it is hoped that it can provide strategies and insights for Khas Collection MSME players in utilizing digital as a means of sales. The purpose of this training is to increase product sales and increase the economic income of Khas Collection MSME entrepreneurs. The results obtained are that the Khas Collection MSMEs in Karangsari Village already have social media accounts such as Instagram and Shopee and have understood the features contained in the application, so that income and sales have increased.
SOSIALISASI PENGENALAN INDUSTRI 4.0 PADA BIDANG TEKNOLOGI PERTANIAN UNTUK SISWA SEKOLAH MENENGAH PERTAMA DI KOTA PAGAR ALAM
Authors:   Institut Teknologi Pagar Alam, Padya Inka Rizki , Erika Desta Ria , Syahputra Asep
Published: October 2023

Pagar Alam City is one of the cities located in South Sumatra Province and is a city producing vegetables and other agricultural commodities. Agricultural products in the city of Pagar Alam, have not been much touched by technological processes because of limited knowledge and lack of interest in learning new things. Therefore, to increase the knowledge of the people of the city of Pagar Alam, it can be done in the next generation, namely teenagers. Adolescence is a period of transition from children to adults. As the next generation of the nation, youth must know about technological advances. This community service aims to provide education to junior high school students as the nation's successors regarding industry 4.0, especially in the field of agricultural technology. The era of the industrial revolution 4.0 is an era of information and technology that influences the field of agricultural technology, with rapid changes.
KEGIATAN PENINGKATAN KESADARAN PAJAK DAN PEMADANAN NIK-NPWP OLEH RELAWAN PAJAK UNIVERSITAS METHODIST INDONESIA
Authors:   Universitas Methodist Indonesia, Goh Thomas Sumarsan , Purba Dimita H. P. , Rumapea Melanthon , Simanjuntak Arthur , Silalahi Mulatua P. , Nainggolan Arison , Purba Sahala , Sembiring Yosephine N.
Published: October 2023

Tax volunteers are a government program, especially the Directorate General of Taxes, to increase tax inclusion in society. The Indonesian Methodist University recruited UMI students to become tax volunteer candidates, then conducted interviews and written tests. The Kanwil will inaugurate the tax volunteers who pass the selection. Tax volunteers this year apart from helping to increase tax awareness and assistance with filling out the SPT and reporting it, they also help socialize and assist in matching NIK-NPWP.
WORKSHOP SENI MERANGKAI BUNGA SEBAGAI PELUANG USAHA KREATIF BAGI IBU-IBU JEMAAT GKPI KHUSUS TELADAN
Authors:   Sekolah Tinggi Ilmu Ekonomi Eka Prasetya, Gultom Pesta , Manik Desma Erica Mariati , Nainggolan Elisabeth , Gea Sanderwan Kristian , Hoki Fernando
Published: October 2023

As knowledgeable people, lecturers are required to educate and advance people's lives. Therefore it is mandatory to carry out community service activities, as proof of the contribution of the lecturers. Lecturers are required to contribute their abilities, both in the fields of knowledge, energy, and materials. Community service programs are carried out through direct interaction through lectures, discussions and practices. The participants as partners are the women members of the GKPI Congregation for Exemplary Church. With this PkM program it can increase the creativity of mothers, through knowledge of interesting flower arrangement techniques, it can be used as new business opportunities so that new entrepreneurs are created.
MENYUSUN KARYA ILMIAH DI PERGURUAN TINGGI
Authors:   Universitas Muslim Nusantara Al Washliyah, Lubis Nazriani , Lubis Asnarni
Published: October 2023

Gatrell, et.al, and School Graduate wrote books containing how to write for a thesis, and dissertation. A book titled A Research Design and Proposal Writing in Spatial Science, Second Edition by Gatrell, et.all has a simple and complete explanation so that it is easy to understand and apply to final writing. Also, the book is supplemented with examples of several interesting titles to be the reference of the research authors, by explaining direct examples in explain background writing, survey libraries, research methods, how to explain the data used quantitative or qualitative to how to manage data correctly. The book How to Prepare Thesis Proposal A Guide for MPhil and PhD Students by School Graduates only explains the general lines of the chapters contained in a thesis. It was concluded that the book written by Gatrell, et.al was more dynamic in accordance with the needs of today’s academics since it also provides the components of crafting research grant fund proposal.
PENERAPAN ALGORITMA C4.5 DALAM MENGUKUR TINGKAT KEPUASAN NASABAH PADA PT BANK MUAMALAT INDONESIA KCU MEDAN BARU BERBASIS WEB
Authors:   STMIK Kaputama, Azli Putri , Jaya Indra Kelana ,   Universitas Methodist Indonesia, Ambarita Indah ,   STMIK Kaputama
Published: October 2023

In the field of service providers, sharia banking and conventional banking have differences in their characteristics which lie in the practice of running business operations, where operations are based on sharia principles, and this principle is the main attraction for customers to utilize sharia bank services. Quality of service is a key factor that will become a competitive advantage in today's banking world. This happens because the bank as a service company has the characteristic of being easy to imitate a product that has been marketed. The measurement method for determining customer satisfaction at Bank Muamalat is by applying data mining, where customer data that makes transactions will be inputted into the system and then processed using the C4.5 method with predetermined criteria. Data mining is a process of finding meaningful relationships, patterns and trends by examining large sets of data stored in storage using pattern recognition techniques. According to Algorithm C4.5 is an algorithm used to form a decision tree.
APPLICATION OF THE GGG PRINCIPLES IN THE PLANNING, IMPLEMENTATION,AND ACCOUNTABILITY ALLOCATION OF VILLAGE FUNDS Study in Desa in Kecamatan Sunggal , Kabupaten Deli Serdang
Authors:   Universitas Methodist Indonesia, Mesakh Januardi , Simanjuntak Arthur , Siahaan Septony B. , Br. Sembiring Vebina N.
Published: October 2023

This research aims toto know and examine the implementation of the principle Good Government Governance (Participation, Transparency, and Accountability) in Planning, Implementation, Accountability for Allocation of Village Funds to villages in Sunggal District, Deli Serdang Regency.The type of research used is causal associative using questionnaires and survey research methods. The approach used in this research is a quantitative approach. The location of the research was carried out in villages in Sunggal District while determining the number of respondents for each village in the form of: Kepala Desa (Kades), Seketaris Desa (Sekdes), Kaur Keuangan, Kasi Pemeritahan serta Lembaga Swadaya Masyarakat. Based on the results of research, partially principles Good Government Governance (Participation) and Good Government Governance (Accountability) has a positive and significant effect on Planning, and Accountability for Allocation of Village Funds, meanwhile Good Government Governance (Transparency) has a positive and insignificant effect on the Village Fund Allocation Implementation. Simultaneously principle Good Government Governance (Participation, Transparency, Accountability) has a positive and significant effect on the Planning, Implementation, and Accountability of Village Fund Allocations.
ANALISIS PERILAKU MEMILIH MASYARAKAT UNTUK PEMILU 2024 DI TINJAU DARI PERILAKU PEMILIH MASYARAKAT DALAM PILRES 2019 Studi Kasus Desa Pantai Cermin Kiri Kecamatan Pantai Cermin
Authors:   Universitas Negeri Medan, Simanullang Alfon Apriel , Pranata Dwi Agus , Natalia Desi , Purba Endhita Putri , Sihaloho Fransisco , Harahap Siti Khoiria , Nasution Risa Elvina , Sitompul Yunike Sarah
Published: October 2023

Democracy gives people the freedom to choose and determine their course of government and democracy is realized through elections, in an election the community has voting behavior that is heavily influenced by various factors so this study aims to find out what factors influence the people of Pantai vermin kiri village, Serdang berdagai sub-district. Different in determining their choice. This research uses a quantitative method that produces descriptive data regarding information through spoken and written words, the results of the research show that psychological and also rational sociological factors are factors influencing the left mirror beach community in choosing the president and Vice President in 2019 these factors are also factors that will influence society in determining their choices in 2024.
APLIKASI PENCATATAN KAS KECIL (PETTY CASH) BERBASIS WEBSITE MENGGUNAKAN METODE WATERFALL
Authors:   Universitas Bina Sarana Informatika, Rahayuningsih Panny Agustia , Yulia Yulia ,   Universitas Bina Sarana Informatika Kampus Kota Pontianak, Rona Rona
Published: October 2023

Sebuah lembaga pemerintahan yang ada di Kota Pontianak adalah Dinas Penanaman Modal, Tenaga Kerja, dan Pelayanan Terpadu Satu Pintu (DPMTKPTSP). Hasil penelitian menunjukkan bahwa pengelolaan petty cash atau kas kecil yang digunakan oleh DPMTKPTSP Kota Pontianak membutuhkan banyak tenaga, waktu yang lama, kesalahan dalam pengolahan data, dan keterlambatan dalam penyampaian laporan penerimaan kas, pengeluaran kas, dan persediaan kas. Oleh karena itu, penelitian ini berfokus pada pengembangan aplikasi pencatatan petty cash yang menggunakan model air terjun sebagai model pengembangan perangkat lunak.Proses pengembangan ini terdiri dari analisis, desain, pengkodean, pengujian, dan pendukung. Untuk Bendahara Pengeluaran dan Kasubag Keuangan, sistem ini memberikan fasilitas kepada dua tingkat akses.Aplikasi petty cash ini dibangun dengan bahasa pemrograman preprocessor hypertext, framework codeIgniter, dan basis data MySQL. Diharapkan sistem yang dibuat ini akan membantu DPMTKPTSP Kota Pontianak mengelola transaksi petty cash dan menghasilkan laporan yang diperlukan.
Diskursus Politik Dalam Proses Pemekaran Wilayah Pantai Timur
Authors: Zakiyah Nurul , Minako Muchlis
Published: October 2023

The purpose of my research is to analyze the regional development of Pantai discourse. Timur Calls for Separation of Ogan Kommering Illil Autonomous Region A district that has undergone a long journey of various local political elites. the method of Investigation using the qualitative descriptive method, a more urgent investigative strategy Searching for meaning using the Pareto theory of political elites (1984-1923). Data is collected by: Interview methodology, data collection, data reduction, data presentation and conclusions. Of As a result of this research, (1) it is the discourse of Pantai Timur development Community needs have led local elites to build means of communication Support at government and community levels. (2) New establishment process This district is subject to many restrictions due to changes in the central government's laws. 2014. Hence the aspirations of the political elite and the support of the community There is still a long way to go in the process and process of creating new districts to acquire and acquire positions. and power in the new governing body.
Konflik Tapal Batas antara Desa Tanjung Telang dengan Kelurahan Payuputat Kecamatan Prabumulih Barat Kota Prabumulih
Authors: Minako Muchlis , Savella Rizky
Published: October 2023

This research is entitled "Border Conflict Between Tanjung Telang Village and Payuputat Village, West Prabumulih District, Prabumulih City". The problem with this research is why it happened Boundary conflict between Tanjung Telang Village and Payuputat Village and resolution of the conflict. The purpose of this study is to explain the occurrence of boundary conflicts between the village of Tanjung Telang and Kelurahan Payuputat, West Prabumulih District, Prabumulih City. This research is a qualitative research whose unit of analysis is the people of Tanjung Telang and Payuputat villages. Data collected by direct observation, in-depth interviews with informants. The research method used is qualitative which consists of three activity streams, namely data reduction, data presentation, and drawing conclusions. The results of this study indicate that the conflict occurred at the border crossing between the village of Tanjung Telang and the village of Payuputat due to several factors, namely the first historical factor, the second factor of different perceptions, and three economic factors.
USE OF REAL OPTIONS TO EVALUATE THE PROFITABILITY OF BIOGAS PRODUCTION FROM STILLAGE IN THE TEQUILA INDUSTRY
Authors: Santiago-Santiago Ana Karen , Arana-Coronado Oscar Antonio , Matus-Gardea Jaime Arturo , Brambila-Paz José de Jesús , Toledo-Cervantes Alma Lilia , Méndez-Acosta Hugo Oscar
Published: October 2023

In Mexico, the tequila industry is the second most important economic activity within the alcoholic beverage industry, after the beer industry. Tequila vinasse is wastewater with a high organic load produced during the distillation of the fermented must of the blue agave (Agave tequilana Weber var. azul), which has a great impact on soils and water bodies in the tequila region. On the other hand, the decrease in fuel reserves causes instability in hydrocarbon prices, which makes it necessary to implement alternative fuel methods such as biogas. In this sense, it has recently been pointed out that the anaerobic digestion process is the most suitable for the treatment of tequila vinasse since it allows the removal of contaminating organic matter, together with the production of biogas that can be used in situ in the tequila industry. In this study, the financial feasibility of the production of biogas for self-consumption from tequila vinasse was calculated with the values achieved from a pilot system composed of a packed bed reactor (PBR) with technological and economic advantages to treat this waste. Profitability was evaluated over a 10-year production horizon (net present value $1 569 001) and was complemented with the Real Options methodology, taking into account price volatility and the option to expand. The results showed that the project is profitable with the 42.85 % biogas production expansion option. It is concluded that biogas production is financially feasible and it is possible to increase the profitability of the system by $6 325 109 if production is expanded.
Bienvenidos al XXIII Congreso Argentino de Diabetes
Authors: Gorban de Lapertosa Silvia
Published: October 2023

Es para mí un enorme desafío coordinar la organización del XXIII Congreso Argentino de Diabetes, que se llevará a cabo en el Centro Metropolitano de Convenciones de la Ciudad de Rosario, del 28 de septiembre al 1.º de octubre 2022, y una enorme alegría recuperar la presencialidad luego de estos duros años de pandemia. En este Congreso, la actividad científica más importante de la Sociedad Argentina de Diabetes (SAD), compartiremos saberes, experiencias y reafirmaremos los lazos de amistad entre los miembros de nuestra querida Sociedad. Queremos reencontrarnos con nuestros socios y con los integrantes del equipo de salud de distintos puntos del país para combinar ciencia y espacios de confraternización, como siempre nos caracterizó como sociedad científica.
Simposio 1: Nuevas insulinas
Authors: Trifone Liliana
Published: October 2023

El primer uso terapéutico de la insulina en 1921 revolucionó el manejo de la diabetes mellitus tipo 1 (DM1) y cambió considerablemente la vida de muchos pacientes con otros tipos de DM. En el último siglo se desarrollaron muchos avances en el campo de la terapia insulínica para lograr el óptimo control glucémico y disminuir las complicaciones por la DM. Aún existen grandes desafíos, como incrementar la flexibilidad en el tratamiento, reducir la hipoglucemia iatrogénica y optimizar la calidad de vida del paciente. Los problemas con el perfil de acción y extrema variabilidad de las primeras insulinas se han resuelto con modificaciones progresivas en su formulación.

Grandes innovaciones en el campo farmacológico condujeron al desarrollo de los análogos de la insulina que mimetizan más fisiológicamente la secreción de insulina pancreática y permiten la incorporación en los tratamientos de los esquemas de insulina basal-bolo. Nuevas formulaciones de insulina exógena se crearon para acelerar o enlentecer su absorción, análogos de insulinas (insulinas de acción rápida), y para prolongar el perfil más plano y prolongado de acción (insulinas basales). Luego de la inyección subcutánea, la molécula de insulina forma hexámeros que deben ser convertidos en monómeros para su ingreso a los capilares. Las insulinas prandiales, insulinas rápidas, se formularon para el control de la glucemia posprandial y de las excursiones glucémicas. En 1990 y 2000 se desarrollaron tres análogos (aspártica, lispro y glulisina) a través de cambios en la secuencia aminoacídica. Posteriormente se incorporaron aditivos (niacinamida, l-arginina, treprostinil, citrato) para facilitar una rápida absorción, lo que generó la producción de análogos de segunda generación ultra rápidos (ultra rápida aspártica, fiasp y urli, lyumjev). La optimización de las propiedades del PK/PD de estos análogos representa un avance en el control metabólico en DM1 más allá de la HbA1c. Las formulaciones ultra rápidas incrementaron el tiempo en rango glucémico y mitigaron la variabilidad glucémica, con disminución de las hipoglucemias. El desarrollo de las formulaciones de insulina basal se ha sustentado en la obtención de un perfil de acción más plano y prolongado. Esto se puede adquirir en base a la generación de hexámeros estables luego de la inyección subcutánea. Estas formas aumentan la flexibilidad terapéutica (momento de inyección) y conveniencia (menor número de aplicaciones), con menor riesgo de hipoglucemias.
Simposio 10: Cascada de señalización de la insulina y del ejercicio en el músculo estriado
Authors: Pavarotti Martín
Published: October 2023

El músculo estriado esquelético es uno de los principales tejidos capaz de regular la glucemia, incrementando el transporte de glucosa tanto al estímulo insulínico como por acción del ejercicio físico. En cuanto a la insulina, sabemos que debe contactar y activar a su receptor, desencadenando una importante cascada de señalización donde intervienen moduladores como IRS, PI3K, Akt, AS160 (TBC1D4), entre otros.

Con respecto a la activación disparada por el ejercicio físico, las vías de señalización dilucidadas hasta aquí demostraron ser esenciales en dicho proceso. Entre las proteínas y vías más estudiadas se encuentran: la activación de proteína quinasa activada por AMP 5ʹ (AMPK), proteínas que sensan calcio (CaMKK, CaMKII and nPKC), las cuales a su vez modifican su estado de fosforilación luego del ejercicio, y una serie de proteínas sensibles al estiramiento (Rac1, PAK).
Simposio 10: Mioquinas
Authors: Rodríguez Martín
Published: October 2023

El músculo esquelético (ME) no es solo una unidad locomotora responsable de la propulsión y regulación de la energía y los procesos metabólicos; ahora se lo reconoce, además, como un órgano capaz de producir moléculas con funciones vitales: las denominadas mioquinas1.

Durante las últimas dos décadas, se hizo evidente que el ME en respuesta al ejercicio funciona como un órgano endocrino, que puede producir y secretar cientos de estas mioquinas que ejercen sus efectos de manera autocrina, paracrina o endocrina, lo que permite una comunicación cruzada entre el ME y otros órganos, incluidos el cerebro, el tejido adiposo, los huesos, el hígado, el intestino, el páncreas, el lecho vascular y la piel, así como con el mismo ME. Aunque solo se ha asignado a unas pocas mioquinas una función específica en humanos, se ha identificado que las funciones biológicas de las mioquinas incluyen efectos en la cognición, el metabolismo de los lípidos e hidratos de carbono, en el empardamiento de la grasa blanca, la formación de hueso, la función de las células endoteliales, en la estructura de la piel y en el crecimiento tumoral. Algunas mioquinas relevantes son la interleucina-6 (IL-6), IL-8, IL-15, irisina, miostatina, factor de crecimiento de fibroblastos 21 (FGF21), factor inhibidor de la leucemia (LIF), factor neurotrófico derivado del cerebro (BDNF) y factor de crecimiento similar a la insulina-1 (IGF-1).
Situación de la obesidad y la diabetes mellitus en la Argentina
Authors: Mociulsky Juliana
Published: October 2023

El sobrepeso y la obesidad constituyen causas frecuentes, en ascenso creciente, de malnutrición en Argentina. La Encuesta Nacional de Factores de Riesgo (ENFR) refleja que el exceso de peso por autorreporte (la suma del sobrepeso y la obesidad), aumentó de modo continuo a lo largo de sus cuatro ediciones: 49, 53,4, 57,9 y 61,6% (2005, 2009, 2013 y 2018, respectivamente). Este notable crecimiento a expensas de la obesidad aumentó casi un 75% entre 2005 y 2018. La prevalencia de exceso de peso por autorreporte fue mayor en el sexo masculino respecto del femenino (68,5% vs 55,0%). Según mediciones antropométricas realizadas durante la Cuarta ENFR de 2018, la prevalencia de exceso de peso fue aún mayor que la autorreportada (66,1% frente a 61,6%). Los grupos sociales de menores ingresos evidenciaron mayores índices de exceso de peso a expensas de mayor prevalencia de obesidad, que fue un 21% mayor en el quintil de ingresos más bajos respecto del más alto.

Coincidiendo con la tendencia en la región de aumento de peso en la población infantil y adolescente, se observa un incremento del 10% de sobrepeso en la población de menores de 5 años y del 3,6% de obesidad. La proporción de sobrepeso y obesidad en la población de 5 a 17 años fue del 20,7 y 20,4% respectivamente. Los adolescentes de bajo nivel socioeconómico tienen un 31% más de probabilidad de tener sobrepeso respecto de los adolescentes del nivel socioeconómico más alto y, la población con nivel educativo “hasta primario incompleto” tiene más obesidad.
Telesalud en época pandémica
Authors: Witman Érica
Published: October 2023

La transformación digital (TD) del sector salud se trata de cómo las tecnologías cambian las reglas de participación, las formas de trabajar e interactuar, y la manera de pensar de una organización. Ofrece la oportunidad de aprovechar el poder transformador de la tecnología, abordar fallas fundamentales y evolucionar los sistemas sanitarios hacia una nueva realidad. Existen tres componentes importantes: personas, procesos y tecnología1.

La telesalud involucra la entrega de servicios de salud usando tecnologías de la información y la comunicación (TICS) cuando la distancia es un obstáculo. Engloba la teleconsultoría, teleinvestigación, telegestión y teleeducación.