bluuebunny/crossref_metadata_2025 huggingface dataset:
Opportunities and challenges for integrating the development of sustainable polymer materials within an international circular (bio)economy concept
Authors: Tarazona Natalia A. , Machatschek Rainhard , Balcucho Jennifer , Castro-Mayorga Jinneth Lorena , Saldarriaga Juan F. , Lendlein Andreas
Published: February 2022

Highlights

The production and consumption of commodity polymers have been an indispensable part of the development of our modern society. Owing to their adjustable properties and variety of functions, polymer-based materials will continue playing important roles in achieving the Sustainable Development Goals (SDG)s, defined by the United Nations, in key areas such as healthcare, transport, food preservation, construction, electronics, and water management. Considering the serious environmental crisis, generated by increasing consumption of plastics, leading-edge polymers need to incorporate two types of functions: Those that directly arise from the demands of the application (e.g. selective gas and liquid permeation, actuation or charge transport) and those that enable minimization of environmental harm, e.g., through prolongation of the functional lifetime, minimization of material usage, or through predictable disintegration into non-toxic fragments. Here, we give examples of how the incorporation of a thoughtful combination of properties/functions can enhance the sustainability of plastics ranging from material design to waste management. We focus on tools to measure and reduce the negative impacts of plastics on the environment throughout their life cycle, the use of renewable sources for their synthesis, the design of biodegradable and/or recyclable materials, and the use of biotechnological strategies for enzymatic recycling of plastics that fits into a circular bioeconomy. Finally, we discuss future applications for sustainable plastics with the aim to achieve the SDGs through international cooperation.

Leading-edge polymer-based materials for consumer and advanced applications are necessary to achieve sustainable development at a global scale. It is essential to understand how sustainability can be incorporated in these materials via green chemistry, the integration of bio-based building blocks from biorefineries, circular bioeconomy strategies, and combined smart and functional capabilities.

Graphic abstract
Aspectos imunofisiológicos dos controladores de elite frente à infecção pelo vírus da imunodeficiência humana
Authors: Marques Larissa , Santana Gabriel , Oliveira Ana , Marques Juliana , Passos Xisto , Silva Antonio , Silva Lucas
Published: February 2022

Introdução: O vírus da imunodeficiência humana (HIV) é responsável por infectar humanos e é considerado o agente etiológico da síndrome de imunodeficiência humana/human immunodeficiency syndrome (SIDA/AIDS). Os sintomas são acarretados pela degeneração lenta e progressiva do sistema imune devido ao ataque aos linfócitos TCD4+. Uma pequena parte da população infectada (1-2%) são denominadas controladores de elite, ou seja, apresentam forma branda da infecção, de forma que o sistema imunológico mantém a carga viral indetectável por um longo período de tempo, sem o uso de anti-retrovirais. Objetivo: Descrever os principais mecanismos envolvidos no controle da infecção por HIV em pacientes controladores de elite para HIV-1, diferenciando-os dos outros pacientes infectados pelo vírus. Metodologia: Trata-se de uma revisão narrativa da literatura cujos dados foram coletados nas bases de dados da Biblioteca Nacional de Medicina (Pubmed), Scientific Electronic Library online (scielo), e de artigos publicados em revistas nacionais e internacionais. Os critérios de inclusão foram artigos em inglês e português que se enquadraram na temática, publicados entre 1998 e 2019 e foram excluídos artigos que não se enquadraram nesse período nem no controle epidemiológico e imunológico do vírus. Resultados: Estudos indicam que pacientes controladores de elite tendem a apresentar uma menor ativação do sistema imunológico, controlando a carga viral ao proporcionarem uma resposta imune rigorosa.  Conclusão: Os mecanismos envolvidos no controle da infecção por HIV e na progressão para a AIDS entre os controladores de elite ainda não estão esclarecidos. Estudos adicionais são necessários para estabelecer benefício aos doentes.
Study of Vacant Electronic States of Chemiluminescence Activators on the Example of 2-Cumaranone Molecules
Authors:   Ufa Federal Research Center RAS, Safronov Aleksey , Tayupov Mansaf ,   Ufa Federal Research Center RAS, Markova Angelina ,   Ufa Federal Research Center RAS, Rakhmeev Rustam ,   Ufa Federal Research Center RAS
Published: February 2022

2-coumaranone molecules were studied by the method of mass spectrometry of negative ions of resonant capture of low (0-15 eV) electrons. This substance is widely used as a platform on which chemiluminescent probes are built. The analysis of the decay channels of molecular negative ions (OI) into stable fragments using the results of quantum chemical calculations in the approximation of the density functional theory allowed us to determine the most probable structures of fragmentation ions ([M – H]–, [M – 2H]–, [M – CO]–).
Reflection of Regular Functions
Authors:   Moscow Institute of Radiotechnics, Electronics and Automatics — Russian Technological University, Pavlov Andrey
Published: February 2022

It is proved in article, that a function with reflection in relation to some point can be the double reflection of initial function in relation to some other points. The double reflection results in the periodicity of some analytical function. In a example we obtain a periodic odd function, if we move the result of two reflections. We obtain a similar result after consideration of the F(p) field: F(p) = f(p − 2A), if p = x + iy, x = A, for all A. The F(A + B + iy) values equal to the f(z − 2A − 2B) values in the A + B + iy point as a result of two moving of the f(p) function to the right for all y (at first we move the f(−A+iy) on the 2A distance, after we move the the F(p) = f(A+iy) = f(p) function on the 2B distance in relation to center in the (A, 0) point); the result of the such double moving is equal to the values of initial field in the A + B + iy point. The reflection of the F(p) field in the (A, 0) and (A + B, 0) points is the f(−p) regular function for all real A, B. We can move the F(p) values in reverse direction (to the left). In the situation the values (in the left part of plane) are equal to the values of initial regular f(p) function. As a result of two moving we obtain a new G(p) field in relation to the f(p) function after the movements to the left with the (−A, 0) center. The regular f(p) function is equal to the G(p) field, if p < −A. It is proved, that the f(p) function is periodic. We can use the f(p) = u + iv equality, if F(p) = u − iv (for the regular f(p) functions with the real values on the imaginary axis). If the f(p) function is regular in the left half of plane, the fact results in the equality f(p) = c too, c=const. The F(p) field is the field of the moved functions.
Sistema de Vigilância Alimentar e Nutricional: tendência temporal da cobertura e estado nutricional de adultos registrados, 2008-2019
Authors: Silva Ruth Pereira Costa , Vergara Clarice Maria Araújo Chagas , Sampaio Helena Alves de Carvalho , Vasconcelos Filho José Eurico , Strozberg Felipe , Ferreira Neto José Fernando Rodrigues , Mafra Matheus Leite Pirani , Garcia Filho Carlos , Carioca Filho Antonio Augusto Ferreira
Published: February 2022

Resumo Objetivo Analisar a tendência temporal da cobertura do Sistema de Vigilância Alimentar e Nutricional (Sisvan) e do estado nutricional, entre adultos acompanhados na Atenção Primária à Saúde do Brasil, 2008-2019. Métodos Estudo ecológico de séries temporais, sobre dados das macrorregiões brasileiras. A variação percentual anual da classificação do estado nutricional e da cobertura total foi estimada pela regressão de Prais-Winsten. Resultados Foram identificados 115.034.534 registros no período. A cobertura passou de 5,0% em 2008 para 10,6% em 2019, com variação anual de 8,4%, intervalo de confiança de 95% (IC95% 6,7;10,0) A obesidade apresentou tendência crescente entre 2008 e 2019, com variação anual de 6,4% (IC95% 5,3;7,3), assim como o sobrepeso (1,8%; IC95% 1,2;2,5). Já o baixo peso (-7,0%; IC95% -8,0;-6,1) e a eutrofia (-3,8%; IC95% -4,1;-3,4) decresceram no período. Conclusão Identificou-se melhora na cobertura do Sisvan, tendo-se observado aumento de excesso de peso e obesidade na população estudada.
Premiership Rugby’s Response to COVID-19: A Competition Law Analysis
Authors: Cisneros Ben
Published: February 2022

Professional sport has undoubtedly been hit hard by COVID-19. Clubs and governing bodies have had to adapt rapidly to the public health emergency and have come under great financial and regulatory strain. Some sports have weathered the storm better than others, though, and professional rugby union experienced significant off-field turbulence, with wages reductions seen across the English Premiership. This article will examine the conduct of Premiership Rugby and its clubs during the COVID-19 crisis from a competition law perspective and will argue that, by acting in concert, Premiership and the clubs may have breached UK competition law.
Revisión sistemática de literatura: MOOC K-12 y STEAM
Authors: Leytón Yela Ginna Viviana , Bucheli Guerrero Víctor Andrés , Ordoñez Erazo Hugo Armando
Published: February 2022

Objetivo:  Identificar los trabajos de investigación centrados en los MOOC K-12 o STEAM, enfocados en el potencial de los entornos de educación, remodelando el marco educativo actual en la educación secundaria. Metodología: Se definieron ecuaciones para realizar las búsquedas de articulos publicados en conferencias y revistas mediante bases de datos bibliográficas, que permitieron sustraer los articulos para construir el corpus de referencias. Posteriormente, se analizan y sintetizan las investigaciones más significativas para el desarrollo de la revisión sistemática. Resultados: Esta revisión permitió identificar las tendencias, desafíos y oportunidades sobre MOOC K-12 o STEAM, identificando las implementaciones de cursos de ciencias de computación o pensamiento computacional en educación secundaria. Este tipo de iniciativas han obtenido resultados positivos, puesto que se han incrementado el número de estudiantes que seleccionan la programación informática como eje fundamental en el examen nacional para educación superior. Conclusiones: Las investigaciones se han centrado en su mayoría en la incorporación de la programación con cursos complementarios ofertados de forma opcional en educación secundaria, con un enfoque combinado, es decir, se llevan a cabo clases tradicionales con el apoyo de los MOOC. La gran mayoría de los MOOC para educación secundaria se han implementado específicamente para satisfacer las necesidades de los docentes y estudiantes de educación secundaria, con el fin de mejorar y apoyar el plan de estudios, y motivar a los estudiantes como futuros miembros activos en la creación de tecnología.
The Anti-Yahweh Label lassaw' in Jeremiah (PART 1)
Authors: Retief Wynand C.
Published: February 2022

ABSTRACT The traditional stance is that לשׁוא in Jeremiah (2:30; 4:30; 6:29; 18:15 and 46:11) denotes futility, mostly translated as "in vain. " This study scrutinises the first three texts (Jer 2:30; 4:30 and 6:29) in an effort to substantiate and modify a recent hypothesis that this term is instead a reference to the god Baal, " The Vain/Worthless One." Support for the said hypothesis is gained by (1) a tentative observation in the discussion of Jer 2:30 that שׁוא futility, "in vain ") is apparently limited to wisdom literature, whereas the Jeremiah texts are part of a cultic-legal corpus within a covenantal setting where the lexeme consistently appears as the prepositional prefixed definite form לשׁוא and apparently refers to prohibited objects of worship; (2) a search for intertexual clues in Jer 4:30; and (3) alertness to recurring key words and chiastic patterns in the context of Jer 6:29. In the course of working through the relevant texts, the notion took shape that the preposition ל־ is -besides meaning "for, for the sake of - a technical term indicating covenantal relationship.1 It therefore seems that לַשָּׁוְא is not only a pejorative reference to Baal but also a label of the contra and anti-Yahweh overlord/s (בעלים/בעל) in (illegal) covenant relation to Israel. Keywords: Jeremiah, Exegesis, Baal, Deities, Worthless
Pençesiz çizgelerde maksimum-yakın bağımsız küme ve üst sınırları için yeni algoritma
Authors: KARCI Şeyda , ARI Ali , KARCİ Ali
Published: February 2022

Günümüzde çizgelerin bazı problemleri için hala yaklaşık çözüm yöntemleri kullanılmaktadır. Bunlar minimum baskın küme, maksimum bağımsız küme, maksimum hizip, mükemmel eşleştirme, Hamilton devresi bunlardan bir kısmıdır. Bu çalışmada maksimum bağımsız küme bulma problemine polinomsal olan bir yöntemin uygulaması üzerinde durulacaktır. Bu amaçla pençesiz çizgelerden olan kral çizgeleri üzerinde örnek çalışmalar gösterilecektir ve pençesiz çizgeler için maksimum bağımsız kümenin eleman sayısı için analitik bir sınır ortaya konulmaya çalışılacaktır.
[RETRACTED] Gold CBD Gummy Bears -Must Read Before Buy!CBD Gummies For Pain Reviews-(UK) v1
Authors: CBD Gummies Gold
Published: February 2022

[RETRACTED]

Gold CBD Gummy Bears -Must Read Before Buy!CBD Gummies For Pain Reviews-(UK)
Qualitative Proteomics Analysis of Proteins and Biomarkers of Alzheimer’ Disease
Authors: Rasheed Maheen , Kareem Kashif , Liaquat Aliha , Ashraf Aneela , Maryam Sania
Published: February 2022

Alzheimer’sdementia (AD) is the plague of today's world: a costly harming illness that ransacks the elder of their capacity to work and affect their recollections. Many years of research have brought about a profound comprehension of the pathological processes and a range of targets of therapy. Proteomics has contributed enormously to these advances and will keep on having a growing role in determining the nature of obsessive injuries. Moreover, proteomics (both gel-based and gel-free, mass spectrometry-based), is probably going to assume an expanding job in distinguishing biomarkers that may aid early determination and in observing movement and above all response therapy. Alzheimer's dementia is a neurodegenerative disease characterized by limited motor functions and loss of memory. Clinically it is diagnosed by accumulation of plaques in neurons and formation of NFTs by the aggregation of tau proteins. These pathological changes in the brain can be observed in preclinical stages of AD known as ASYM AD and mild cognitive dementia.
Genetic Epidemiological Studies of Diabetes Mellitus in Hospital Population of District Bahawalpur
Authors: Waseem Muhammad , Ullah Farhat , Arshad Romana
Published: February 2022

Diabetes is considered a disease that is characterized by high glucose levels in the blood. Diabetes has become a global epidemic disease which is most common in developing countries. The aims are to provide an estimate of diabetes prevalence in the hospital population of district Bahawalpur. The study was carried out on 1000 Diabetic patients, Data was collected by a well-designed Questionnaire. In the statistical analysis, the percentage (%), Standard Error (S.E), mean (M), and Chi-Square tests were used. Out of 1000 Diabetic patients, 39.6% (396) were females and 60.4% (604) were males. The mean age was 51.57 ± 0.50 years in females and for the males, it was 47.99 ± 0.53. A greater number of patients belonged to the urban areas with 70.5% (705/1000) and Minimum belonged to Rural areas with 29.5% (295/1000). BMI recorded in the maximum range of 23-26.9 with 39.9% (399/1000) of the patients while it is recorded minimum the range of ≥27 with 10.1% (101/1000). By family history, much of the diabetic patients belonged to the consanguinity group with 35.7% (357/1000), while it was minimum in the out of cast 7.8 (78/1000). Type II Diabetes mellitus was more common with 64.2% (642/1000) and less common with 35.8% (358/1000). A more fetal onset of Diabetes occurs in the patients with Diabetic family history.
Benefits and Effectiveness of Automatic Farmer Pest Repellent
Authors: Nurikhsani Krisna Dwi , Mupita Jonah
Published: February 2022

Indonesia is one of the countries that is famous for its extensive agricultural land so it is not surprising that Indonesia is called an agrarian country. In addition, most of the population earns a living as farmers, but this does not make Indonesia the largest rice producer in the world. Apart from that, farmers in Indonesia have difficulty dealing with pests that make them suffer losses due to crop failure. This study aims to explain the benefits and effectiveness of an automatic tool that can repel farmer pests, especially rats and birds. In this tool there is a Passive Infrared Receiver sensor that functions to detect the presence of farmer pests, then the servo motor will activate the bell, and pull the bell to produce a sound that scares birds and mice. The mechanism is controlled by a microcontroller, namely Arduino ATmega 2560. This tool is an innovation from previous technologies so that farmers' problems regarding farmer pests can be solved easily.
Implicaciones y perspectivas del mix hídrico para el abastecimiento de agua potable en el sureste de España
Authors: Bernabé-Crespo Miguel Borja
Published: February 2022

La Mancomunidad de Canales del Taibilla (MCT) realiza el abastecimiento de agua potable para la mayor parte del sureste de España, un área de clima mediterráneo semiárido con escasez estructural de agua. Con los datos de este organismo, se realiza un estudio del consumo de agua en el siglo XXI (2000-2019), en cuanto al volumen distribuido y la procedencia de cada recurso hídrico. Se analiza la evolución de los aportes para el mix hídrico de las aguas superficiales, trasvasadas y procedentes de la desalación. Se subraya que se ha diversificado la oferta del recurso y que es necesario mantenerla, paralelamente a la mejora de las redes de distribución y concienciación socioambiental.
Digital space and its influence on the lifestyle and health of students: A literature review
Authors: Shubochkina Evgeniya I.
Published: February 2022

This article presents an analytical review of international publications, for the period from 2012 to 2020, that focused on the influence of the digital space as a new social factor that changes the lifestyle of the younger generation and creates new health risks. The literature search was conducted in PubMed using the Cochrane Library, Scopus, and Web of Science. Digital technologies provide positive opportunities of online education of students and schoolchildren, including greater availability of educational and preventive programs. The main health risks associated with the intensive use of digital technologies in education and leisure include manifestations of visual overstrain (computer visual syndrome), disorders of the musculoskeletal system (pain in the neck, back, and hands), and negative lifestyle changes. Adolescents are more susceptible than adults to such negative consequences of intensive use of digital space, which leads to the development of Internet addiction, sleep disorders, eating disorders, psychosocial manifestations, poor academic performance, depressive symptoms, and aggressive behavior. Aggressive behaviors of some young people in the Internet space include harassment (cyber-bullying) and sending sexual messages (sexting) accompanied by cyber-attacks. Against the background of the growing use of digital tools, including the availability of smartphones, parents, teaching, and medical staff of universities and schools should provide early prevention interventions of the above-mentioned negative phenomena. Preventive online programs can be used by college students during the period of adaptation to new learning conditions to reduce alcohol consumption, smoking, and formation of stereotypes of proper nutrition.
La voz latinoamericana: percepciones sobre integración y comercio: diciembre 2021
Authors:   Instituto para la Integración de América Latina y el Caribe
Published: February 2022

Desde el Instituto para la Integración de América Latina y el Caribe (INTAL) del Sector de Integración y Comercio (INT) del Banco Interamericano de Desarrollo (BID) se realizó un análisis de la opinión que los ciudadanos de América Latina tienen sobre la integración regional, así como sobre otros fenómenos vinculados al comercio como la inversión extranjera directa, la digitalización y la inmigración. Los datos utilizados para el estudio corresponden principalmente a los resultados del año 2020 de la encuesta Latinobarómetro, que constituye uno de los principales bancos de datos de opinión pública en América Latina. Se trata de una encuesta de carácter presencial y anual en 18 países de la región, con muestras representativas de cada país, que aplica un cuestionario común con una unidad metodológica y técnica. La encuesta permite captar las diferentes opiniones, actitudes, comportamientos y valores de los latinoamericanos encuestados. Los resultados abarcan una muestra representativa de 600 millones de habitantes y los temas principales de su abordaje y seguimiento son la democracia, el estado de la economía, el desarrollo social de los países y los esfuerzos de integración regional, entre muchas otras temáticas.
Evaluation of IDB Lab: Evaluation of Operations and Summary of Findings
Authors: Haarsager Ulrike , Barbosa Fernando , De Santis Stefania , Putic Melanie , Hoekman Frank , Michelitsch Roland
Published: February 2022

El presente informe recoge los hallazgos de la segunda fase y las conclusiones y recomendaciones generales de una evaluación de BID Lab a cargo de la Oficina de Evaluación y Supervisión (OVE) del Banco Interamericano de Desarrollo (BID). OVE realizó la evaluación en dos fases superpuestas. La primera de ellas (de abril de 2020 a mayo de 2021) evaluó la pertinencia del mandato, el enfoque estratégico y la estructura institucional de BID Lab (documento MIF/RE-5-6), mientras que en la segunda, realizada de febrero a octubre de 2021, evaluó las operaciones y los productos de conocimiento de BID Lab.
Desenvolvimento regional: análise do potencial de municípios do meio oeste catarinense para formação de rota turística com foco em vitivinicultura
Authors: Biasi Juliana Aparecida , Rechia Ana Carolina
Published: February 2022

Buscando o desenvolvimento regional de municípios do Meio Oeste Catarinense através da proposta de uma rota turística com foco em vitivinicultura, este estudo tem como objetivo mapear os municípios da região que se enquadram dentro do perfil para a rota. Durante a pesquisa foi realizada a coleta de dados verificando a legislação, diretrizes, infraestrutura turística básica e rotas existentes que já se beneficiam do turismo. Foi possível concluir que o Meio Oeste catarinense apresenta potencial turístico não explorado e que necessita de adaptações e melhorias.
O cinema de rua como intervenção pontual em uma cidade desigual: o caso do Alpendre CineARQ em Pau dos Ferros/RN
Authors: Andrade Daniel Paulo de , Mangueira Vitoria Raissa Ferreira
Published: February 2022

A partir de um novo panorama a respeito da relação entre cinema, arquitetura e urbanismo, articulando-os às questões de apropriação e debate da cidade, o presente artigo tem como objetivo construir pensamentos sobre alternativas que não estavam prescritas na racionalidade do planejamento urbano, mas que emergem para transformar a ideia de espaços inertes e definitivos. Dessa maneira, focará na atuação do Alpendre CineARQ, um projeto de pesquisa e extensão da Universidade Federal Rural do Semi-Árido (UFERSA), campus Pau dos Ferros – RN, que utiliza o cinema de rua como forma de micro-resistência urbana. Nesse viés, a metodologia debruçou-se em investigar referências que versem sobre a temática, assim como analisar e documentar as sessões do projeto de extensão Alpendre CineARQ. Como conclusão, as ações do grupo encontram na ocupação dos espaços públicos e nas discussões dos filmes exibidos possibilidades de fomentar cultura, preservar e conectar identidades.
Unusual Localised Skin Reaction due to Ondansetron: Case Series
Authors: Brahmbhatt Shruti , Brahmbhatt Vihang , Shah Nehal , Rajput Mahavirsingh
Published: February 2022

Ondansetron is an antiemetic drug that belongs to 5-hydroxytryptamine (5-HT3) receptor antagonists group. It has been widely used to treat nausea and vomiting due to chemotherapy, post surgery or due to any other gastrointestinal problem with 5-HT3 receptors involvement. The typical adverse drug reactions of Ondansetron include headache, dizziness, constipation or diarrhoea. Here, we have observed the skin reaction around the site of injection following Ondansetron administration. Recognition of this hypersensitivity reaction may allow better preparedness of clinicians to manage this condition.
Psychotherapy in the Management of the Upcoming Storm of Post-COVID Spectrum of Psychological Disorders
Authors: Ponnam Hima Bindu , Akondi Butchi Raju
Published: February 2022

No Abstract.
Mapping of Reproduction Disorders Caused by Infectious Diseases in Bali Cattle (Bos sundaicus) in Muna Regency, Indonesia
Authors: Aku Achmad S. , Yaddi Yamin , Saili Takdir , Hafid Harapin , Munadi La Ode M. , Dewi Fitria , Kete Surya C.R.
Published: February 2022

Background: The Government of Muna Regency, Southeast Sulawesi Province, in Indonesia, made Bali cattle a leading livestock commodity. The problem faced by farmers is the slow increase in population, which is caused by reproduction disorders. Mapping of animal diseases can be used as a guide in determining the location of cattle farming development. This study aims to determine the spread of infectious diseases found in Bali cattle in the Muna Regency. A total of 27 blood samples were obtained from the jugular veins of the cattle in Muna Regency in 9 sub-districts, that were suspected to have an infectious disease. Methods: The samples were then tested using the ELISA method for Septicaemia epizootica, Infectious Bovine Rhinotracheitis and Trypanosomiasis, while the test for Brucellosis was conducted in parallel between RBT and CFT. Result: Brucellosis and Infectious Bovine Rhinotracheitis were absent, however, the prevalence of Septicaemia epizootica disease was in all regions. Trypanosomiasis disease is found in 55.5% of Bali cattle breeding centers in Muna Regency, in adjacent areas, Septicaemia epizootica was the disease with the highest rate of infection followed by Trypanosomiasis which was partial in some regions.
How to Deal With Sexual Changes During and After Pregnancy
Authors: de Pierrepont Catherine , Brassard Audrey , Lessard Isabelle , Gingras Anne-Sophie , Péloquin Katherine
Published: February 2022

After documenting parenting couples’ needs regarding perinatal sexuality, this study developed and evaluated a brief psycho-educational workshop on perinatal sexuality. Participants (16 future and 17 new parents) completed five steps: (1) online questionnaire (T1) assessing needs toward the workshop and sexoperinatal knowledge, attitudes, and perceptions; (2) 2-hour online workshop on perinatal sexuality; (3) post-workshop satisfaction questionnaire; (4) 1-month (T2) and (5) 2-month (T3) post-workshop questionnaires with the same measures as in T1. One month after the workshop, knowledge, attitudes, and perceptions toward perinatal sexuality increased significantly. Sexoperinatal interventions from health-care workers are still uncommon, although there is a need for information and support. This brief online workshop is promising for better education and empowerment of parenting couples regarding perinatal sexuality.
My Drug-Free VBAC During Covid
Authors: Treyster Larisa
Published: February 2022

In 2016, I had a complicated cesarean. My daughter was breech and I ended up with a crash cesarean resulting in internal organ damage; furthermore, she was born with a complete cleft lip and palate, so breastfeeding was not possible. In spring 2020, as the world was locking down for Covid, I found out I was having a baby boy, due in September. I wanted to try for a VBAC (vaginal birth after cesarean) to reduce my risk of complications and to heal emotionally from the complicated cesarean. My OB-GYN advised me to stay home as long as possible, as my designated hospital was not known for encouraging VBACs. I woke up on August 29 at 4:30am, 2 weeks before my due date, having mild contractions. I ate, read a book, and timed my contractions and tried to be quiet so as not to wake anyone up. By 6:30am, the contractions were strong so I woke up my husband and we dropped our two girls off with a family friend. We dropped them off at 7:20 and raced to the hospital. Luckily the hospital was only 2 miles away. I showed up fully dilated and ready to push. I would have had my son in the parking lot if a bystander hadn't brought a wheelchair. I had to sign a consent paper and do the rapid Covid test after delivering my son. It was an incredibly healing birth.
Tropical Climate Less Affects Covid19 Transmission than Population Density: Perspective of Indonesia
Authors: Rovik Anwar , Pratama Anggi , Rahayu Ayu
Published: February 2022

Introduction: Indonesia is ranked the 4th most populous country in the world. Since Covid19 is highly transmissible from human to human, Indonesia might suffer a long period of the Covid19 pandemic than other less-populous countries. This study aimed to find the correlations of tropical climate, population density and confounding factors with Covid19 progression in Indonesia from March to August 2020. Methods: The climatological data, population density, laboratory testing, and the confirmed Covid19 cases were statistically analyzed. The correlations between each data were performed with Pearson’s Correlation Coefficient using a Statistical Package for the Social Sciences. The values of statistical significance were considered at 95% and 99% confidence intervals. Results and Discussion: Indonesia recorded more than 1,315 confirmed Covid19 cases in almost all provinces (30 out of 34) during the dry season (March to August 2020). During the early pandemic, DKI Jakarta and East Java have been the epicenters of the pandemic in Indonesia. Humidity and precipitation have a weak negative correlation, while the temperatures have a weak positive correlation. Population density and laboratory testing have a strong positive and significant correlation with the cumulative confirmed Covid19 cases. Conclusion: Our study indicates that tropical climate less affects the cumulative Covid19 case in Indonesia than population density and laboratory testing capacity.
Zebrafish models of inherited retinal dystrophies
Authors: Perkins Brian D.
Published: February 2022

Inherited retinal degenerations (IRDs) cause permanent vision impairment or vision loss due to the death of rod and cone photoreceptors. Animal models of IRDs have been instrumental in providing knowledge of the pathological mechanisms that cause photoreceptor death and in developing successful approaches that could slow or prevent vision loss. Zebrafish models of IRDs represent an ideal model system to study IRDs in a cone-rich retina and to test strategies that exploit the natural ability to regenerate damaged neurons. This review highlights those zebrafish mutants and transgenic lines that exhibit adult-onset retinal degeneration and serve as models of retinitis pigmentosa, cone-rod dystrophy, and ciliopathies.
The design of the Coconut Peeling and Splitting Machine using TRIZ Method
Authors: Banda Yohanes Patrik Adventus , Mulyono Julius , Santosa Hadi
Published: February 2022

Copra is one of the most interesting materials, is a type of coconut which is dried using a heating process. Copra is commonly used as a part of material to produce cleanser, for the human body, such as soap and shampoo. There is a big opportunity for using copra, so we need to design an equipment for supporting copra production efficiently and faster. This research aim is to help the farmers, so they can meet market needs which are increasing day by day. Copra processing still uses traditional production methods. This study aims to design a coconut stripping and splitting device using the TRIZ method. Doing a simple experiment, resulting shorter processing of coconut peeling and breaking, showed an average time of 39.65 seconds for each piece of coconut.
EVALUASI PELAKSANAAN PROGRAM PENGUATAN PENDIDIKAN KARAKTER (PPK) SELAMA PANDEMI COVID-19 DI SEKOLAH DASAR
Authors: Retnasari Lisa , Hidayah Yayuk , Ulfah Nufikha , Gustika Siraten Donita
Published: February 2022

Penelitian ini bertujuan untuk mendeskripsikan pelaksanaan program penguatan pendidikan karakter di sekolah dasar. Di SD Muhammadiyah Karangkajen terdapat program PPK berbasis satuan tugas (satgas) khusus PPK untuk membentuk leader school by student to student dalam mengimplementasikan dan memanifestasikan nilai-nilai karakter kedalam berbagai aspek kehidupan. Penelitian ini menggunakan metode evaluasi dengan pendekatan kualitatif dan model CIPP (Context, Input, Process, Product). Teknik pengumpulan data melalui wawancara, observasi dan dokumentasi. Teknik analisis data melalui reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian ini (1) tahapan konteks (context) visi dan misi, kebijakan sekolah, dan peluang yang dimanfaatkan sesuai antara yang dicanangkan oleh pemerintah dengan yang diimplementasikan; (2) tahapan masukan (input) program PPK selama pandemi berjalan dengan adanya koordinasi antara guru pendamping PPK, wali kelas, dan peserta didik. Sarana dan prasarana, pembiayaan dana, dan kondisi lingkungan sosial sekolah dan masyarakat sudah mendukung pelaksanaan program PPK; (3) tahapan proses (process) rincian pelaksanaan program PPK selama pandemi sesuai dengan realita di lapangan; (4) tahapan produk (product) peserta didik selama pandemi lebih ditonjolkan nilai religiusitas dan kemandirian.
Ashes to Ashes, and Dust to Dust: Is Scattering Garden the Sustainable Destination for Cremated Ashes?
Authors: Ng Sai-Leung
Published: February 2022

Cremation is commonly practiced around the world because it requires small space for the disposal of ashes and also causes less environmental impacts. Among various options for ash disposal, many people choose to scatter the ashes of their loved ones in a scattering garden. Is scattering garden a sustainable solution to the disposal of cremated ashes? No research has ever attempted to answer this question based on empirical data. This study aimed at filling the research gap by characterizing and evaluating the vegetation performance of a scattering garden after it had been open for ash scattering for six years. The results indicated that, overall, approximately half of vegetation was degraded to either unhealthy or bare soil. The area of bare soil in the lawns of high scattering level was larger than that of low scattering level. Furthermore, the belowground biomass of vegetation in the lawns of high scattering level was significantly lower than that of low scattering level. It is concluded that the current practice of ash scattering in Hong Kong was not sustainable and the intensity of impacts was dependent upon the level of ash scattering. The findings of this study may provide a reference for the policy and management of ash scattering in Hong Kong and other cities around the world.
Development and Validation of Radiomics Signatures to Predict KRAS Mutation Status Based on Triphasic Enhanced Computed Tomography in Patients with Colorectal Cancer
Authors: Cao Yuntai , Zhang Jing , Huang Lele , Zhao Zhiyong , Zhang Guojin , Li Hailong , Guo Bin , Xing Yue , Zhang Ying , Bao Haihua , Zhou Junlin , Ren Jialiang
Published: February 2022

Purpose: In this study, we used computed tomography (CT)-based radiomics signatures to predict the mutation status of KRAS in colorectal cancer (CRC) patients. Methods: This study involved 447 patients who underwent KRAS mutation testing and preoperative triphasic enhanced CT. They were categorised into training (n = 313) and validation cohorts (n = 134) in the ratio 7:3. Radiomics features were extracted from CT imaging. The Boruta algorithm was used to retain the features closely associated with KRAS mutation. Multivariate logistic regression was used to develop radiomics, clinical, and combined clinical-radiomics models for KRAS mutation. The receiver operating characteristic curves were used to evaluate the predictive performance and clinical usefulness of each model. Results: Fourteen radiomics features were retained as the as final signatures for predicting KRAS mutations. Delayed phase models showed superior predictive performance compared to arterial phases models or venous phase models. The clinical-radiomics fusion model showed excellent performance, with an AUC, sensitivity and specificity were 0.772, 0.792 and 0.646 in the training cohort, while 0.755, 0.724 and 0.684 in the validation cohort, respectively. Conclusions: The clinical-radiomics fusion model can be used as a potential imaging marker for preoperative detection of KRAS mutation status.
Effect of Age and Sex on The Associations Between Potentially Modifiable Risk Factors and Both Type 2 Diabetes and Impaired Fasting Glycaemia among West African Adults
Authors: Issaka Ayuba , Cameron Adrian , Paradies Yin , Bosu William Kofi , Houehanou Yèssito Corine Nadège , Kiwallo Jean Baptiste , Wesseh Chea Sanford , Houinato Dismand Stephan , Nazoum Diarra , Stevenson Christopher
Published: February 2022

IntroductionType 2 diabetes Miletus (T2DM) is becoming one of the leading causes of morbidity and mortality worldwide, including among Africans. Knowledge of the association between risk factors and both diabetes and pre-diabetes, and whether these differ by age and sex, are important for designing targeted interventions. However, little is known about these associations for African populations.MethodsThe study used data from WHO STEPS surveys, comprising 15,520 participants (6,774 men and 8,746 women) aged 25-64 years. Chi-square and T-test were used to compare differences in the prevalence of risk factors for both sexes. Multinomial logistic regression was conducted to ascertain the relative risks (RR) and 95% confidence intervals (CI) for both T2DM and IFG relating to each risk factors, including obesity (defined by BMI, waist circumference (WC), waist to hip ratio (WHR), and waist to height ratio (WHtR)), high blood pressure (HBP), fruit and vegetable consumption, physical inactivity, alcohol consumption and smoking. Models for each risk factor were fitted with interactions for age and sex.ResultsFactors associated with T2DM and IFG were age, BMI, waist circumference(WC), waist to hip ratio(WHR), waist to height ratio(WHtR), hypertension, physical inactivity, smoking, alcohol, fruit, and vegetable consumption]. Significant interaction with age was observed for the association between hypertension and T2DM(p = 0.05); WHtR and T2DM (p = 0.007) and WHR with IFG (p= 0.006).ConclusionThe study found that for most risk factors examined, associations with both IFG and T2DM did not vary by age and sex. Policies for the prevention may consider the impact of risk factors equally among adults of any age or sex in West Africa.
Coping with Personal Care and Stigma: Experiences of Persons Living with Schizophrenia
Authors: Commey Isaac Tetteh , Ninnoni Jerry Paul K. , Ampofo Evelyn Asamoah
Published: February 2022

Schizophrenia has an impact on social functioning and participation in everyday life. Yet, there is little data on the experiences of coping with personal care and stigma among people living with schizophrenia in Ghana. This study sought to fill this gap using a qualitative exploratory study. A non-probability sampling procedure, specifically criterion sampling, was used to access a total of nine persons living with schizophrenia. Data were obtained from semi-structured interviews and subjected to Colaizzi's descriptive phenomenological data analysis approach. The study revealed that people with schizophrenia could adopt specific personal measures to take care of themselves. Some of these subjective measures included Activities of Daily Living such as washing, sweeping, maintenance of personal and environmental hygiene and medication administration. Strict adherence to treatment regimens has helped to take care of themselves so long as they were in their lucid interval. Despite the anxiety, stress, fear and sadness associated with stigmatisation, participants coped with stigma by resorting to strategies such as avoidance, denial and wishful thinking.
Performance of the Dexcom G6 continuous glucose monitoring system in persons with type 1 diabetes mellitus during moderate exercise
Authors: Dijk Peter R. , Lommerde Nicole , Fokkert Marion , Edens Mireille A. , Hernández Alberto Díez , Álvarez Elías Delgado , Slingerland Robbert , Bilo Henk J.G.
Published: February 2022

Background Real time Continuous Glucose Monitoring (rt-CGM) is used by patients with type 1 diabetes mellitus (T1DM) during various circumstances. Limited data is available concerning the performance of the widely used Dexcom G6 rt-CGM during moderate exercise. Methods Prospective, investigator-initiated study to test the performance of the Dexcom G6 rt-CGM during moderate exercise. Seventeen participants with T1DM went hiking for 6 days, followed by 6 days of normal daily activities (NDA). Capillary glucose measurements were performed with Precision Neo Pro strips; previously verified to be closely comparable with the gold reference method. Results Two persons dropped out of the study and 4 had incomplete data. Consequently 11 participants with a median age of 55 [interquartile range 39-62] years, 91% female and median HbA1c 55 [interquartile range 40-75] mmol/mol were analyzed. During moderate exercise the mean absolute differences and mean absolute relative differences of the Dexcom G6 rt-CGM were 20±17 mg/dl and 16±15%. Overall, the Dexcom G6 rt-CGM reported higher glucose concentrations, compared to capillary measurements, during exercise (154±64 vs. 149±70 mg/dl (p<0.001)). When assessing accuracy during exercise compared to the capillary measurements using Parkes error grids, 98.6% of the comparisons fell within zones A and B. According to the Integrated Continuous Glucose Monitoring Approvals (Class II–510(K)) guidelines, the Dexcom G6 rt-CGM did not reach the agreed upon cut-off levels and were more or less comparable as during NDA. Conclusions Despite limitations, this study demonstrates that during moderate exercise the Dexcom G6 rt-CGM does not meet current benchmark criteria. Trial registration: This study was approved by the Medical Ethical committees in The Netherlands (Isala Hospital; NL70456.075.19/190605) and in Spain (CEIm de las Áreas de Salud de León y del Bierzo; no.1981). Registered at www.trialregister.nl: NL7922.
Machine-Learning Approach Using FDG-PET-Based Radiomics in the Characterization of Mediastinal Bulky Lymphomas.
Authors: Abenavoli Elisabetta Maria , Linguanti Flavia , Barbetti Matteo , Mungai Francesco , Miele Vittorio , Nassi Luca , Puccini Bendetta , Romano Ilaria , Santi Raffaella , Passeri Alessandro , Sciagrà Roberto , Talamonti Cinzia , Vannucchi Alessandro Maria , Berti Valentina
Published: February 2022

Purpose: Mediastinal bulky involvement is common in lymphomas, particularly in classical Hodgkin lymphoma (cHL), primary mediastinal B-cell lymphoma (PMBCL) and grey zone lymphoma (GZL). Despite advanced methods of assessment, traditional imaging appears insufficient in differentiating histology. This study tested the diagnostic value of 18F-FDG PET/CT volumetric and texture parameters in the histological differentiation of mediastinal bulky due to GZL, PMBCL and cHL, also using a machine-learning approach. Methods: We retrospectively reviewed patients with mediastinal bulky disease with a histopathological diagnosis of cHL, PMBCL or GZL who underwent pre-treatment 18F-FDG PET/CT. Lesions were delineated using a fully automated preselection of 18F-FDG avid structures defined by a threshold SUV ≥ 2.5. Volumetric and radiomic parameters were measured using LIFEx software both for bulky lesion (BL) and for all lesions (AL) on 18F-FDG PET/CT. Analysis of selected radiomic features was performed with Machine Learning classifiers based on Logistic Regression. Results: We reviewed 117 patients (29 PMBCL, 80 cHL, 8 GZL). The analysis showed significant differences between the 3 lymphoma groups regarding SUVmax, SUVmean, BL/AL-MTV and BL/AL-TLG. Several PET textural features both of first order and of second order grey-level showed significant differences between the 3 groups. Finally, machine-learning classifier provided good accuracy in the discrimination between groups. Logistic Regression showed good performance, confirming true positive rate (TPR) and true negative rate (TNR) greater than 80% in the characterization of PMBCL and cHL. The multiclass classifier showed TPR greater than 70% and TNR lower 5% in the identification of PMBCL and cHL and TPR of 44% in GZL. Conclusion: Mediastinal bulky involvement from different histologies showed diverse 18F-FDG-PET radiomic features and the machine-learning approach successfully identified the different subtypes. Our results support the potential of metabolic heterogeneity as an imaging biomarker, and the use of radiomic features for early characterization of mediastinal bulky lymphoma.
Prediction of noninvasive ventilation failure in COVID-19 patients: A retrospective observational study
Authors: Silva Luís Neves da , Fernandes Rui Domingues , Costa Ricardo , Oliveira Ana Andrade , Mosca Ana Margarida , Sá Ana Oliveira , Oliveira Bárbara Fontes , Martins Marta Braga , Mendes Marta Lemos , Carvalho Alexandre , Moreira Pedro Silva , Cruz André Santa
Published: February 2022

Background: In COVID-19, there are no available tools or guidelines for the difficult task of recognizing which patients do not benefit from keeping advanced respiratory support, such as noninvasive ventilation (NIV). Identifying failure is crucial to deliver the best possible care and optimize resources in overloaded healthcare systems. Therefore, this study aimed to build a model that predicts NIV failure and consequent death in COVID-19 patients.Methods: This is a retrospective observational study with critical COVID-19 patients who needed NIV but were not candidates or did not need invasive mechanical ventilation, admitted between 1st October 2020 and 31st March 2021, in a tertiary Portuguese hospital. The measure of interest was NIV failure, defined as COVID-19 related in-hospital death. A binary logistic regression was performed, where the outcome (dead vs alive) was set as the dependent variable. Using the independent variables of the logistic regression a decision tree classification model was implemented. Results: The 103 patients included had a mean age of 66.3 years old (SD=14.9), 38.8% were female and 82.5% autonomous. The developed prediction model was statistically significant (X2= 119.865; p< .001) with an area under the curve (AUC) of 0.994. Higher age, higher number of days with increases on FiO2, higher number of days of maximum expiratory positive airway pressure, lower number of days on NIV, and lower number of days from disease onset to hospital admission were, with statistical significance, associated with increased odds of death. A decision-tree classification model was obtained to achieve the best combination of variables to predict the outcome of interest. Conclusions: This study presents a model to predict death in COVID-19 patients treated with NIV (AUC of 0.994), including easily applicable variables that mainly reflect patients’ evolution during hospitalization. Along with the decision-tree classification model, these original findings have the potential to help clinicians define the best therapeutical approach to each patient and optimize medical resources. However, further research is needed on this subject of treatment failure, not only to understand if these results are reproducible but also, in a broader sense, to help fill this gap in modern medicine guidelines.