bluuebunny/crossref_metadata_2025 huggingface dataset:
Chemical composition of hays of the Caatinga shrub legumes mororó and sabiá from different parts of the plant
Authors: De Oliveira Osniel F. , De Lima Amanda F. , Dos Santos Mércia V. F. , Guim Adriana , Da Cunha Márcio V. , Lira Mário De A.
Published: May 2018

Native forages are important feed sources in the northeastern semi-arid region of Brazil. The objective of this study was to evaluate the chemical characteristics of hays made from the native shrub legumes, sabiá (Mimosa caesalpiniifolia Benth.) and mororó [Bauhinia cheilantha (Bong.) Steud.], using different plant fractions, leaves only or leaves plus twigs. Analyses carried out were: concentrations of dry matter (DM), crude protein (CP), neutral detergent fiber (NDF), ether extract (EE), ash, total digestible nutrients (TDN) and non-fiber carbohydrates (NFC). Sabiá leaf hay contained greater CP concentration (182 g/kg DM) than mororó leaf hay (126 g/kg DM) but hay made from leaf plus twigs showed similar CP for both legumes (mean 106 g/kg DM). Concentrations of NDF (368 g/kg DM), NFC (418 g/kg DM) and TDN (481 g/kg DM) of mororó leaf hay were superior to those of sabiá leaf hay (465, 258 and 311 g/kg DM, respectively). The findings suggest that these native legumes can be conserved as hay during the growing season to provide a supplementary feed with acceptable nutritive value for feeding during the period of inadequate feed availability and quality in semi-arid Brazil. However, more samples from a range of growth stages and locations are needed to confirm these preliminary findings and to provide data on possible yields, while more feeding studies with ruminants are needed to confirm the preliminary data in terms of liveweight performance.
Agronomic characterization of Paspalum atratum Swallen and P. lenticulare Kunth
Authors: Marcón Florencia , Urbani Mario H. , Quarin Camilo L. , Acuña Carlos A.
Published: May 2018

Paspalum atratum and P. lenticulare are perennial grasses, native to South America. The objective was to evaluate seasonal growth, frost tolerance, cattle preference, nutritional characteristics, seed yield and germination of 11 ecotypes of P. atratum and P. lenticulare with regard to their potential as alternatives to introduced species. Forage yield was evaluated during 3 growing seasons between 2011 and 2014. Digestibility and CP concentration were assessed in summer 2014, cattle preference in winter 2013 and summer 2015, frost tolerance after the first frosts in June 2012, flowering time during 2013 and 2014 and seed yield and germination in 2014. A marked warm-season growing period was observed for both species with annual forage yields varying from 5 to 12 t DM/ha. Flowering did not occur until autumn, with mean seed yield of 280 kg/ha and germination of 16% for P. atratum and 19% for P. lenticulare. Most ecotypes were able to tolerate winter temperatures and behaved as perennials. Although no differences were observed for DM digestibility and CP concentration among accessions, cattle preferentially grazed accession P. atratum U44. Further studies are needed to evaluate persistence under grazing and animal performance.
Cardiovascular Responses in the Treadmill Stress Exercise in Young Adults of Sarajevo in the Period of the War
Authors: Nakaš-Ićindić Emina , Mujić Muzafer , Knežević Željka , Frljak Nermina , Kulenović Husein
Published: May 2018

his study was designed and performed under very difficult conditions during intensive war activities in Sarajevo. The specific characteristics of this aggressive war were a long lasting. Middle Ages siege of the city with sudden shelling and shooting of civilian targets. It can be expected that these abnormal, stressful conditions caused changes in mental and emotional reactions, as well as in the functioning of numerous organic systems. The aim of this study was to assess whether the long exposure to war conditions influenced the functioning of the cardiovascular system and its response in stress exercise in young adults of Sarajevo.

Multistage, incremental exercise treadmill testing under the Bruce protocol was performed by 14 male students of Sarajevo University (aged 18-23 years). It was planned for each subject to complete two exercise sessions in a three-month interval. Only 8 persons completed the second session because some of the subjects left Sarajevo, some were wounded, and the rest of them had to complete their duties in the Army.

The results of the two exercise sessions showed that resting values of the cardiovascular variables (heart rate, arterial blood pressure) were within physiological range. The mean maximal exercise capacity expressed as metabolic units (METS) was 15.40 for the first exercise session and 15.23 for the second one. There were neither significant differences in exercise test duration between the two exercise sessions nor in maximal achieved heart rate.

It could be concluded that in young men the overall exercise capacity was well preserved but the other results (indirectly calculated maximal oxygen uptake, V02) indicated hyperreactive response. The three-month interval was short to emphasize the differences because the war conditions, under which the testing was performed, were not changed.
The Effects of Combined SarCNU and Ganglioside Treatment of Growth of C6 Glioma Cell Cultures
Authors: Jevrić-Čaušević Adlija
Published: May 2018

In vitro antiproliferative effects of SarCNU and GMI ganglioside were tested in different concentration ratios in C6 glioma cell culture. Based on MTT assay and a protein assay, cytotoxicity of each agent separately and the two agents combined was tested. When the cells were treated with different concentrations of ganglioside ranging from 10-’ to 10-2, the number of viable cells decreased highly on days two and seven, regardless of the concentration of the agent applied. SarCNU, as expected, has caused antiproliferative effects which highly correlated with the concentration of the agent tested. When the C6 glioma cell culture was treated with the two agents combined in the optimal concentration causing the above mentioned cytotoxicity, effects observed did not correlate with those observed for each agent alone, suggesting in this case the expression of highly neuroprotective effects of ganglioside GMI.
Assessment of chronic neuropsychological effects of mercury vapour poisoning in chloral-alkali plant workers
Authors: Pranjić Nurka , Sinanović Osman , Karamehić Jasenko , Jakubović Rušid
Published: May 2018

A prospective case study was conducted in the Department of Occupational Medicine, Tuzla. The purpose of this study was to indicate negative effects from occupational exposure to mercury on behavioural and mental health, memory and psychomotor function that was tested in 46 chloral-alkali plant workers (mean age was 38. 8+/- 5. 7 years; mean age of occupational history 16. 5+/- 6. 0 years). Data on toxicological monitoring on atomic absorption spectrometer, and data on mental health were collected, psychiatric and other subjective symptoms, and behavioural, psychomotor and memory function tested. The data were compared to control group, 32 healthy non exposed workers. The study was designed to assess blood and urine mercurylevels and length of occupational exposure and investigate its relationships to effects on the mental health. The mean air mercury levels were 0.23 mg/m3, the mean blood mercury concentrations was 3. 6 mg/ dl and the mean urine mercuryconcentrations were 151.7 +/- 180.4 mg/l. In 25 (53%) workers exposed to mercury vapour was identified Depression-Hypochondrias Syndrome (p trend < 0. 001) with higher scores for scales: Hysteria (p trend <0. 001), Schizoid and Psychoastenia (MMPI). All psychological parameters were in highly significantly correlations with mercury levels and length of occupational exposure. Pathological parameters were possible general identified if the concentration of blood mercury levels are >2. 9 mg/ dl, or urine mercury levels > 87 mg/l workers exposed to mercury vapour knew that toxic effects in body resulted in loosing some of intellectual abilities, and that people who handle chemicals had an increased health risk (ESW questionnaire). The occupational mercury exposed workers had introvert behaviour (EPQ). Aggressiveness was found in 71.7% workers. The cognitive disturbances: short-term memory loss, difficult to concentrate on tasks which require attention and thinking, were significantly differed compared to those of controls (p trend < 0. 001). In 24 (52%) exposed to mercury workers we have determined ego strength loss and regressive defensive mechanisms (LB). Handwriting disturbances-micrography we have identified in 27 (58.7%) workers.
Mitochondrial medicine - a key to solve pathophysiology of 21 century diseases
Authors: Kiseljaković Emina , Jadrić Radivoj , Hasić Sabaheta , Ljuboja Lorenka , Radovanović Jovo , Kulenović Husein , Winterhalter-Jadrić Mira
Published: May 2018

Over the past 13 years mitochondrial defects have been involved in wide variety of degenerative diseases - Parkinson disease, Alzheimer dementia, arteriosclerosis, ageing and cancer. Mitochondria are believed to control apoptosis or programmed cell death. Disturbance in mitochondrial metabolism has also been implicated in many common diseases such as congestive hart failure, diabetes and migraine. Scientific investigations have showed complexities in mitochondrial genetics, but at the same time, pathophysiology of mitochondrial diseases is still enigma. Mitochondria and their DNAs are opening the era of "mitochondrial medicine". What we today call "a mitochondrial medicine" is only a part of the whole panorama of diseases based on disordered mitochondrial function.
Posttraumatic stress disorder (ptsd) and co-morbidity
Authors: Ličanin Ifeta , Redžić Amira
Published: May 2018

Posttraumatic Stress Disorder (PTSD) very often occurs accompanied with other psychiatric disorders such as: Alcohol and Drug abuse, Personality Disorder, General Anxiety Disorder, Obsessive Compulsive Disorder, Schizophrenia etc. Sometimes it might be a problem for clinicians to differ PTSD symptoms from symptoms of coexisting psychic disorders. The aim of this study was to present the most common PTSD coexisting psycho-disorders. This research was conducted during the period from April 1998 to October 1999. Participants were divided in two groups each containing 30 examinees. The first group consisted of 30 participants with symptoms of PTSD only while the second group included participants who suffered from both PTSD and other psychic disorders (co-morbidity). Both groups were quite similar regarding participants gender and age. The scientific tools used in the research were: Standard Psychiatric Interview, Harvard Trauma Questionnaire (HTQ), Hamilton Anxiety Rating Scale, Hamilton Depression Rating Scale, and Drug and Alcohol Abuse Checklist. Our research results are indicating that PTSDsymptoms are most common in middle-aged persons, regardless of their gender and age. We have found following coexisting psychic disorders: personality disorder 46.6% (from which 13.3% is permanent personality disorder after the traumatic experience); depression 29.9% (depression without psychotic symptoms 23.3% and depression with coexisting psychotic symptoms 6.6%); drug abuse 13.3; alcohol abuse 6.7% and dissociative (conversion) disorder 3.3%. The results of our work are suggesting that co-morbid psychic symptoms have significant regressive influence on PTSD course and prognosis.
The 4-arylaminocoumarin derivatives log P values calculated according to Rekker's method
Authors: Završnik Davorka , Špirtović Selma , Muratović Samija
Published: May 2018

In the QSAR (quantitative structure-activity relationship) and QSPR (quantitative structure-property-activity relationship) study physico-chemical property, lipophilicity is used, to predict bioactivity of the newly synthesized coumarin compounds. Lipophilicity is a property of a molecule which depends on and can be changed by modifications in molecular structure. The parameter of the lipophilicity, partition coefficient (log P), is commonly used in drug designing and it is a numeric characteristic of lipophilicity of the examined substance, potential drug. The synthesis of 4-arylaminocoumarins derivatives from 4-hydroxycoumarin, has been carried out. In this work we described the fragmental method of calculation of partition coefficient according to the Rekker's method, because the best correlation between calculated and experimental values log P was determined according to the Rekker model. 4-Arylaminocoumarin has negative value of log P, but substitution with alkyl or allyl groups on the position 3 increases lipofilicity. Introduction of methyl or ethyl group into position 3 increases lipofilicity, suggesting that by increasing the chain length the values of log P become higher. The influence of allyl substituent in position three increases lipophilicity similar to methyl group. The aryl supstitent decreases lipoflicity, but a general relationship among them could not be established. The results obtained in this study enable further synthesis of new coumarin derivatives and predict their biological activity and properties.
Experimental model of the burn wound topical treatment
Authors: Čabaravdić Amra , Zulić Irfan , Mornjaković Zakira , Mijanović Mirjana , Bečić Fahir
Published: May 2018

AbstractBACKGROUND AND PURPOSE:Clinical research of drugs is a researching step subsequent to the preclinical studies in experimental animals. The aim of our research was to evaluate animal model of wound healing process after the burninducement and effects of the ointment containing natural plants on the process of burn healing.MATERIAL AND METHODS:Burn wounds were experimentally induced in two species of experimental animals which were treated with topically applied herbal preparation with concomitant monitoring of the healing process. Experimental groups (1) of 15 animals each (mice and rats), while control group (2) of 10 animals each (mice and rats) that were not being treated with herbal ointment. After the hair removal, burn was induced on the back of animals by heated brass seal. Different clinical symptoms including oedema of surrounding tissue, redness, exudation, size of the burn surface, histological and microbiological findings were monitored on the days 1, 3, 7, 14 and 21. A statistically significant difference was observed throughout descriptive statistics and paired Student's t-test.CONCLUSION:Physiological healing processes of the acute burn wound following the topical application of herbal preparation can be monitored on the utilized animal model. A three-week treatment resulted in the 90% of completed epithelization in both animal species, indicating the effectiveness of topically applied herbal preparation.
Olanzapine in Treatment of Patients With Bipolar 1 Disorder And Panic Comorbidity: A Case Study
Authors: Oruč Lilijana , Čavaljuga Semra
Published: May 2018

Anxiety disorders are frequently co-morbid with bipolar disorders (BP). Anxiety symptoms can have a great impact on course of illness and patient’s quality of life. Olanzapine is the first antipsychotic approved as a mood stabilizing agent. In this paper two cases of BP 1 disorder where panic attacks co-occur treated with olanzapine were presented. In both cases olanzapine showed very good effects in treatment of panic symptoms within the course of BP disorder.
Thin layer chromatography-application in qualitative analysis on presence of coumarins and flavonoids in plant material
Authors: Kovač-Bešović Elvira E. , Durić Kemal
Published: May 2018

Drugs, natural medicinal plant, animals and mineral materials, have a large and various application in official pharmacy and medicine. Carriers of multilateral pharmacological effects that those drugs shown, are chemically define as active components that are present in them. Methods of qualitative and quantitative analysis are used for the chemical investigation of components that drugs contain. Method of thin layer chromatography has been shown as very reliable. According to the chemical investigation of single drugs, it is possible to define a group of compound or single compound comparing them with standards. Relating to the usage of method of thin layer chromatography, it has been carried out investigation on presence of coumarinsand flavonoids in domestic plant material that have wide everyday usage. Coumarins and flavonoids from the point of view of chemical belonging are phenol derivatives with important pharmacological effects. Applying method of thin layerchromatography, it is detected presence of coumarins and flavonoids substances in plant material that has been tested. Anethi graveolens fructus et folium (fruit and leaf of dill), Anethum graveolens L., Apiaceae, Avenae sativae fructus (fruit of oats), Avena sativa L., Poaceae and Asperulae odoratae herba (sweet woodruff), Asperula odorata L., Rubiaceae. Chromatograms are developed in systems cyclohexane-ethylacetat (13:7) and toluene-ether (1:1) saturated with 10% acetic acid, and visualisation by observing on UV lamp (254 and 366 nm), spraying with reagents KOH (10% ethanol solution) and diphenylboryloxyethylamine (1% methanol solution).
Rehabilitation of extremity war injuries with lesion of peripheral nerves in "PRAXIS" Centre for Physical Medicine and Rehabilitation, Sarajevo
Authors: Pecar Džemal , Karić Mediha , Kulenović Husein , Masić Izet , Kiseljaković Emina
Published: May 2018

Polytrauma with significant lesion of peripheral nerves is a specific war injury. It is also one of the most delicate problems in rehabilitation treatment because it requires a close cooperation with surgeon and timely surgical interventions. Based on our experience, the best results in the treatment of injured persons with lesion of peripheralnerves have been accomplished after the surgical treatment. Results in the neurolysis were better than those accomplished in neurorrhaphy. Total of 436 patients with lesion of peripheral nerves were recorded and 56 patients with plexus lesion. Out of this number, 78 patients (about 15%) had surgical treatment (41 neurorrhaphy and 37 neurolysis). Due to lack of adequate ENMG diagnostics, the objective valorisation of treatment outcome was not possible.
Introduction of the new analytical approaches to the doping control on the XIV Winter Olympic Games
Authors: Nikolin Branko , Lekić Meliha , Sober Miroslav
Published: May 2018

In this paper we present introduction and development of some new analytical methods for identification of anabolic steroids, their metabolites and certain hormones, especially determination of exogenous testosterone by means of gas chromatography-mass spectrometry. Identification of central nervous stimulants and corticosteroides has been performed by high performance liquid chromatography. In desire to achieve better results, to increase strength and endurance, to sharpen reflexes and to reduce stress and anxiety athletes as well as other people use different pharmacological substances, hormones or even illicit drugs. Use of these substances without medical supervision can lead to adverse effects to one's health or even cause a death. At the same time, use of such substances means a kind of cheat that could not be accepted. This is why International Olympic Committee started at 1968 with official dopingcontrol that is permanently carried out and continuously increasing number of banned substances. Doping controldemands for discover and development of new sensitive and specific methods for detection of banned substances and their metabolites in urine and blood.
Computed tomography review of the osseous structures of the orbital apex
Authors: Kapur Eldan , Dilberović Faruk
Published: May 2018

In this paper, we described osseous anatomy of the orbital apex using CT in axial and coronal projections. The main osseous landmarks facilitate the evaluation of orbital apex in radiology, especially on the axial and coronal CT scans. These landmarks include so called optic strut, small segment of the greater wing of the sphenoid bone and upper part of the pterygopalatine fossa. We also concentrate attention upon visualisation and review of the optic canal, superior and inferior orbital fissure, pterygopalatine fossa and foramen rotundum.
Cloning-dilemmas-third-millennium-where to go in the future?
Authors: Gavrankapetanović Faris
Published: May 2018

“We think that science has already explained all when explained movement of the Moon around the Earth. But the real world is not universe like a simple pendulum clock.”Jim York, a physicist from the University of Maryland who coined the name “chaos”We are assured that the field of “Human Cloning” comprise the most crucial scientific questions of present time. It seems that all exaltation of its progress and fascinating results have vanished while being replaced with the cogitative concern that Immanuel Kant expressed in three fundamental questions:What can I know?What should I do?What may I hope?While considering all these questions famous philosopher thought about any human being.Today, these queries consideration is based on the experience of illuminator “ingress” in all that exist, as well as in the human being itself. Experience of the “illumination” triumph seduces science beyond its achievements and freedoms. We would say that science wants even beyond its real wants. Nowadays, global scientific impact appears as general opinions correlated to the universe of technological utilisation, professionalism in knowledge and biological science influence on the behavioural inducements.The basic thinking principles established by modern science are inseparable from the statements of philosopher Descartes: “World of mind and world of body are separated as individual substances that exist separately without any needful co-existence”. In that way, a new authoritative scientific relation towards the world has been created, out of which, the field of values “Heavens are devoid of the glory of God” (A.N. Whitehead, “Science and the modern world”) has been completely excluded or eliminated.It is obvious that the crucial postulations of nature are created throughout gathering of the sufficient data and simplification of the numerous correlative causes and consequences in other to elucidate “the anarchy of systems” and accomplish the exact predictions of their attitudes. Amazing technological progress in 20th century made many people believe that some day science would find out all ignorance of nature and improve the control over it. According to that assumption, the attitude of very complex dynamic systems would finally conform to the scientific formulations and calculations.A fascinating thoughtful help of chaosologists, particularly in their theory of fractals that revealed an apprehension of the reality as made from worlds within self-similar worlds i.e. worlds within dimensions, is necessary for the proper quantification of defect associated with the progress in knowledge of life. That knowledge has been previously neglected to the simple scientific facts and responsibilities (especially in medicine) that naturally appear from inside when life is recognised as a holistic system.
Diagnostic usefulness of serum carcinoembryonic antigen determinations in breast cancer patients
Authors: Mujagić Zlata , Mujagić Hamza
Published: May 2018

Background and purpose: Carcinoembryonic antigen (CEA) is used as a tumour marker in breast cancer (BC). In order to assess diagnostic value of CEA in BC we examined its serum levels and frequencies of its increase in breast cancer patients (BCP), and compared them to those in controls. We also determined CEA in patients with metastatic and non-metastatic BC, and calculated sensitivity and specificity of CEA in BC.Patients and methods: The main experimental group consisted of 47 female patients with histologically proved diagnosis of BC. There were two control groups: clinically healthy women, and female patients with other locations of cancer. Circulating levels of CEA were measured by means of immunoradiometric assay. Results were processed by means of t-test and two-way analysis of variance.Results: Circulating levels of CEA, before treatment in BCP, were significantly higher (p<0.0001) than in healthy women, and in patients with other cancers (p<0.007), while serum CEA in other cancer patients was significantly higher (p<0.01) than in healthy control. There was a difference between frequencies of CEA increase in BCP and healthy women, while such a difference did not exist between BCP and other cancer patients. The circulating levels of CEA in metastatic BCP were significantly higher (p<0.03) in comparison to non-metastatic patients. Sensitivity and specificity of CEA in BCP was 65.0%, and 57.1%, respectively.Conclusions: CEA does not have high tumour specificity for BC, since its circulating levels as well as frequencies of its increase may be elevated in patients with other types and locations of cancer, different from breast cancer. CEA can be detected in the serum of majority of patients with metastatic BC. CEA may be used as prognostic tumour marker in advanced BC.
SARS: current overview, aetiology and epidemiology
Authors: Čavaljuga Semra , Faulde Michael , J. Scharninghausen Jerrold
Published: May 2018

At this moment, public health authorities, physicians and scientists around the world are struggling to cope with a severe and rapidly spreading new disease in humans called severe acute respiratory syndrome, or SARS. According to World Health Organisation (WHO) this appears to be the first severe and easily transmissible new disease to emerge in the 21st century. Though much about the disease remains poorly understood, including the details of the causative virus, we do know that it has features that allow it to spread rapidly along international air travel routes. As of 10 May 2003, a cumulative 7296 probable SARS cases with 526 deaths have been reported from 30 countries on three continents (WHO, ProMED). In the past week, more than 1000 new probable cases and 96 deaths were reported globally. This represents an increase of 119 new cases and 8 new deaths compared with 9 May 2003 (China (85), Taiwan (23), and Hong Kong (7) represented the overwhelming majority, with one additional case each reported from France, Malaysia, Singapore, and the United States). Only in China, as of 10 May 2003 (WHO) total of 4884 with 235 deaths have been reported. Some outbreaks have reassuring features.
Hantavirus host/virus interactions within Southeast Europe
Authors: Scharninghausen Jerrold J. , Faulde Michael , Cavaljuga Semra
Published: May 2018

Viral studies have historically approached their phylogenetic analysis without consideration of the impact of the role the host plays in evolution. Our study examines host/viral interactions through analysis of the phylogenetic relationship between hantavirus genetic sequences and host cytochrome B sequences. Phylogenetic analysis of known Hantavirus genetic sequences were performed using PAUP 3.1.1 (vers. 4.0.0d64). Only sequences available through GENBANK were analyzed. Phylogenetic analysis of hantavirus sequences revealed distinct patterns based upon geographic area. These patterns coincided with the known ranges of reservoir hosts. Multiple hosts for individual viruses and multiple viruses in a single host species for hantaviruses have been described. This may be due to accidental exposure, host-switching, co-speciation, or broad co-accommodation. Since the host is the actual environment that the virus survives in, changes in the host over time could potentially directly influence changes in the virus. Multiple viruses and hosts collide in Southeastern Europe increasing the prospect of finding distinct viral/host relationships. Rodent Cytochrome B is very well conserved and can be used to tract host lineage. By tracking the relationship of infected hosts, we theorize that patterns in host DNA will emerge that will mirror patterns in viral sequences. This analysis of the host DNA could provide an understanding into the causes of variation in hantaviral sequences, pathogenicity, transmissibility, infectivity, viral range and expand our knowledge of viral/host interactions. Surveillance for viruses in the field should include analysis of the host DNA in combination with the viral analysis.
Influence of long term stress exposure on somatisation symptoms outcome
Authors: Hasić Sabaheta , Kiseljaković Emina , Jadrić Radivoj , Zečević Belma , Avdagić Nešina , Nakaš-Ićindić Emina , Radovanović Jovan , Winterhalter-Jadrić Mira
Published: May 2018

Long term stress exposure results in somatisation symptoms appearance. Cardiovascular, respiratory, gastrointestinal and muscle-bone symptoms arise because of intensified activity of autonomic nervous system caused by chronic stress. The aim of the study was to examine the relationship between long term war stress exposure and appearance of somatisation. 40 students of health-care faculties in Sarajevo, of both sexes, were included in investigation and divided in two groups-somatisation and control. Somatisation group subjects (N=20) lived in B&H under war conditions, from 1992-1995. Control subjects (N=20) spent the same period outside B&H. For evaluation of somatisation symptoms we used SCL-90-R test. The obtained data were statistically evaluated using Student’s t-test and χ2 test. Confidence level was set at ρ < 0,05. Our results showed statistically significant difference in somatisation level between somatisation and control subjects group. Different intensity of appearance of certain symptoms in male and female was established. The score of somatisation dimension between somatisation and control group showed statistically significant level (p < 0,0001). Study results confirmed correlation of chronic stress exposure (living in war environment) and somatisation symptom appearance. Individual organic systems had various level of symptom expression. The influence of sex on intensity of individual symptoms of somatisation is possible.
Basic charasteristics of information system of health insurance in FB&H
Authors: Dzubur Amela , Besic Asim , Omanic Ajnija , Dzubur Alen , Niksic Dragana
Published: May 2018

Due to the territorial and administrative division in the war period, information system of health protection after the war was divided in two systems, what matched organisation of health insurance in that period. Those information systems were incompatible, developed on different, both, hardware and software. Therefore, Ministry of Health, within the project "Basic hospital services", financed through the World Bank loan, applied new, common information system in health insurance. Goal of this paper is to present basic features of information system of healthinsurance in FB&H, as well as the way of its functioning in respect to other institutions included in the system, respective data bases, sites of entering and updating data, while using data available with Federal Bureau of Health Insurance.
Risk factors of fall in elderly people
Authors: Avdić Dijana , Pecar Džemal , Mujić-Skikić Emela
Published: May 2018

Falls are the leading accidental cause of death among elderly people in their homes. Falls and their consequences are the primary reason in 40% of admissions to hospitals for people older than 65 years. The study population consisted of 77 randomly selected patients of both genders older then 65 years. Each patient was tested in his/her home and was completely informed about the methodology and the goals of investigation. Based on the exclusion criteria, three patients were excluded from the study, which means the investigation was conducted on 27 males (35.06%) and 50 females (64.94%) with the average age being 71.23 ± 5.63 years.For each patient, a specially prepared questionnaire about risk factors was filled in. The sum of affirmative answers represented a relative index of fall risk. All patients were evaluated through Folstein’s Mini-Mental State Examination Test that is suitable for on-sight use in patient’s home. The score value over 20 excludes dementias, delirium, schizophrenia and affective disorders.Considering the values of the risk factor, scores obtained by the questionnaire and MMSE test scores, statistically significant differences were found between males and females (p < 0.005, respectively p < 0.01), “fallers” and “non-fallers” (p < 0.001, respectively p < 0.01), while considering the relation to the way of living (alone or with family), there were no statistically significant differences (p > 0.05).
Study of the changes in the position and the pattern of changes of the brain arteries in fetuses and full-term stillborns
Authors: Kulenović Amela , Dilberović Faruk
Published: May 2018

We studied cerebral blood vessels in 20 fetuses of the gestation age between 16-36 weeks, and in 5 full-term stillborn cadavers by the method of dissection. One portion of the brain samples were processed by filling the blood vessels with 10% solution of formalin, whereas in the other group we used Mixobar and injected it through carotid artery to demonstrate brain arteries. In early fetal life the arteries are thin and have a straightforward pattern, which is in a direct correlation with the development of the brain. In brain arteries of a 28-week old fetus we observed progressive changes at all three brain arteries that began to assume more curved pattern. Since a significant increase in the brain growth and formation of the gyruses and sulcuses of the brain occurs in the 32nd week, the arteries also assume a wavier pattern, and the number of its branches increases. In full-term stillborns, the arteries are much larger in caliber, they branch abundantly, and due to relatively wide brain sulcuses we may also conclude that their pattern is partially tortuous. From our results it is evident that there are changes in the position, pattern and relationship of brain arteries that are parallel with the brain development and formation gyruses and sulcuses of the brain.
Development of the rat telencephalon-volumetric analysis
Authors: Aličelebić Selma , Grbeša Đurđica
Published: May 2018

With regard to intensive morphometric changes, morphometry as a method is mainly used for histogenetic studies of brain development in normal and experimental conditions. The aim of our study was to quantitatively analyse morphological parameters of the rat telencephalon during embryonic development. The investigation was carried out on semithin serial sections of rat brain from embryonic days 12 to 15. The volume densities (VV) of the lateral ventricles, the telencephalic neuroepithelium and the surrounding mesenchyme have been analysed stereologically and compared in examined embryonic stages. The neuroepithelial volume density was the smallest (28%) at E13 and the biggest (44%) at E15 (p<0.0005). The mesenchymal volume density was the smallest (32%) at E13 and the biggest (48%) at E14 (p<0.0005). The volume density of lateral ventricles was the biggest (40%) at E13 and the smallest (14%) at E15 (p<0.0005). Neurostereological methods have been making a very valuable contribution to neuroscience over recent years. We have used unbiased stereological counting methods to obtain objective quantitative parameters which show relations between some parts of rat embryonic telencephalon examined during its normal development.
Study on Skull Asymmetry
Authors: Sarac – Hadzihalilovic Aida , Dilberovic Faruk
Published: May 2018

The aim of this study is to determine the type of skull as well as to examine its internal appearance and configuration of skull base. Special attention is given to the direction and position of the pyramid of the temporal bone, the volume and appearance of all the three cranial fossas, and the direction and appearance of crista alaris - all of those compared to the skull type.Considering the obtained results (specially for crista alaris and middle fossa) we can ascertain outstanding independence of sphenoid bone and its parts in the formation of cranial base. Located in the middle of the skull, in front of strong pyramids transversal axis and two vertical axis, frontal crest and internal occipital crest, it by itself with her lesser wing presents an important transversal axis of cranial base. Cases in which crista alaris with its position does not follow the type of skull (in 20 % cases crista alaris does not follow skull protuberances), may probably be explained by strong and independent development of this bone, which is placed among other bones of cranial base like a peg. It also, by itself dictates form and configuration of the middle part of skull. That is also confirmed by middle fossa which, according to its position in the middle of cranial base and relation with sphenoid bone, shows significant deviation with respect to posterior fossa (follows the type of skull in 47 % cases).
Editorial
Authors: Board Editorial
Published: May 2018

We have completed publication of seven authors’ oral presentations given on 15. February 2003. at Symposium “Scientific, ethical and religious dilemmas on the status of human embryo and its cloning”.This journal invokes increased interest amongst workers engaged in almost all the fields complementary to basic research and implicit to biological as well as biomedical science.In the situation when financial and human potential of our country border on existence and the young and the talented continuously migrate to the developed and wealthy countries, integration of all the existing resources and research teams and presentation of their research results seems to be possible only in a journal capable of combining them all.However, we are certain that our cooperation with the developed scientific communities will result in repatriation of scientists from our country who work there successfully, and in their integration into environment which they left not only to ensure existence for themselves but also to satisfy scientific curiosity and become competent modern experts.With all the sincerity, we offer to them collaboration in the presentation of their research results in our journal, as well as joint realization of scientific research.May, 2004Editorial Board
Sectional anatomy of auditory tube
Authors: Meznarič-Petruša Marija , Cvetko Erika
Published: May 2018

The auditory tube connects the tympanic cavity with nasopharynx. Due to its structure and position, it is difficult to demonstrate the auditory tube in its whole length and to study its topography on anatomical specimens. The purpose of our study was to present the sectional anatomy of the auditory tube in order to facilitate understanding of its structure and topography. We utilized serial sections of the cadaveric head in four planes: transverse, oblique, frontal and sagittal. The osseous part of the auditory tube was demonstrated on transverse sections and most of the cartilaginous part on oblique sections of the head and neck. The tensor veli palati muscle was found to consist of bilaminar muscle sheet: the outer part originating from the skull base and the inner part originating from the lateral cartilaginous lamina and membranous part of the tube. Topographic relations seen on four section planes were described in detail. The structure, course, and topography of auditory tube are well demonstrated on sectional images. Detailed knowledge of the sectional anatomy of the auditory tube is important for the interpretation of corresponding computerized tomographic and magnetic resonance images, and in understanding the disorders and diseases affecting the middle ear and mastoid.
Sonophoresis-mechanisms and application
Authors: Vranić Edina
Published: May 2018

There are numerous methods of administering drugs to the body, both passive and active. Active methods include the use of penetration enhancers and assisted drug delivery. One of them is sonophoresis (phonophoresis). This term is used to describe the effects of ultrasound on the movement of drugs through intact living skin and into the soft tissues. Although the exact mechanism of sonophoresis is not known, drug absorption may involve a disruption of the stratum corneum lipids allowing the drug to pass through the skin. In the future, drug release systems aided by ultrasound may be able to provide slow release of vaccines. Researchers are currently exploring the applications in various areas like cutaneous vaccination, transdermal heparin delivery, transdermal glucose monitoring, delivery of acetyl cholinesterase inhibitors for the treatment of Alzheimer's disease, treatment of bone diseases and Peyronie's disease and dermal exposure assessment. The possibilities seem endless. Drug administration through skin patches, with the advent and development of ultrasound-mediated transdermal transport, may soon become the name of the game. Besides, taking into account the varied possible applications of sonophoretic transdermal drug transport in the fields of biotechnology and genetic engineering, we can envision a whole gamut of newer technologies and products in the foreseeable future.
Some aspects of the psychoactive substances abuse in adolescents
Authors: Redžić Amira , Ličanin Ifeta , Hadžihalilović Jasminka
Published: May 2018

Cannabis is a plant whose consumption causes hallucinations soon after it has been inhaled. This study was conducted with 600 adolescentsof age 12 to 17 with even gender distribution from two residence locations (rural and urban). Epidemiological-analytic study was prospectively conducted, whose results were analysed with standard statistical methods. The results showed that the use of cannabis is greater by the adolescents in high school (15-17 years old), than the adolescents in the elementary school (12-14 years old). The x2 test showed great significance. Among the tested adolescents the consumption of cannabis is more present in urban than in rural type of residency. However, gender structure did not show significant differences. It is obvious that the prevention of the use of psychoactive substances should be at its maximum.
Significance of establishing collateral circulation by leptomeningeal anastomoses in the occlusion of arteriae cerebri mediae
Authors: Kulenović Amela , Dilberović Faruk
Published: May 2018

We have investigated establishment of collateral circulation in patients with cerebral circulation disorder. Thirty angiograms of patients treated at Neurological Department of Hospital Centre in Sarajevo suffering from arteriae cerebri mediae occlusion were used for this study. Cerebral anastomoses that included connections between arteriae cerebri anterior and arteriae cerebri mediae over leptomeningeal anastomosesoccurred in some patients suffering from occlusion of this arteriae. It was concluded that the majority of anastomoses existed between big leptomeningeal branches of postcommunicant segment of a. cerebri anterior and branches of cerebri mediae. These collaterals are of great significance as their functional ability is sometimes of a high degree in cases of occlusion of one or the other artery. It can be concluded that anastomosing of the blood vessels increases their volume in the whole and therefore more blood can be provided, although physiological factors should not be neglected, as functional effectiveness of collateral circulation in postocclusive states depends also on the state of the whole cerebrovascular system, then on the speed of creation of occlusion (thrombosis or embolism), systemic arterial pressure, volume and viscosity of the blood.
The effects of McKenzie and Brunkow exercise program on spinal mobility comparative study
Authors: Mujić Skikić Emela , Trebinjac Suad , Avdić Dijana , Čakota Slavica
Published: May 2018

This study encompassed 64 participants with symptoms of low back pain, 33 in McKenzie group and 31 in Brunkow group. Patients attended exercise program daily and they were asked to do the same exercise at home--five times a day in series of 5 to 10 repetition each time, depending of stage of disease and pain intensity. All patients were assessed for the spinal motion, before and after the treatment. All parameters for spinal movements showed improvement after exercising McKenzie program for lower back pain with a significant difference of p<0.01 for all motions. Also, in Brunkow group, all of the parameters showed statistically significant improvement at the end of treatment in relation to pre-treatment values, with significant difference of p<0.01 for all motions. Statistically comparison between McKenzie and Brunkow difference in score at the end of the treatment showed statistically significant improvement in McKenzie group, for extension, right and left side flexion, while flexion score didn't show statistically significant difference. McKenzie exercises seemed to be more effective than Brunkow exercises for improvement in spinal motion. Both, McKenzie and Brunkow exercises can be used for spinal mobility improvement in patients with lower back pain, but is preferable to use McKenzie exercises first, to decrease the pain and increase spinal mobility, and then Brunkow exercises to strengthen the paravertebral muscles.
Endodontic-periodontal locally delivered antibiotics
Authors: Lačević Amela , Vranić Edina , Zulić Irfan
Published: May 2018

Endodontic pathology is a bacterial disease. It is well established that periapical disease is the result of bacteria, their product, and the host response to them. Periradicular disease will occur after microorganisms and their metabolic products affect the periradicular tissue. Aim of using antibiotics as part of a treatment regimen is to achieve, within the periodontal environment, a concentration of the drug that is sufficient either to kill (bactericidal) or arrest the growth (bacteriostatic) of pathogenic microorganisms. There are two possible approaches to improve the drug action: sustained and controlled drug release to reduce or eliminate side effects by improving the therapeutic index and site-specific drug delivery to minimize systemic effects. These two strategies have been explored by the association of drugs with different vehicles, either naturals or synthetics. A wide variety of specialized local delivery systems (i.e.intrapocket devices) have been designed to maintain the antibiotic in the GCF (gingival crevicular fluid) at a concentration higher than the MIC (minimum inhibitory concentration). Fibres, films, strips and microparticles made of biodegradable or non-biodegradable polymers have been reported as effective methods to administer antibacterial agents for periodontal therapy. Together with these solid devices, semisolid adhesive or non-adhesive formulations have also been proposed.
Management of Open Fractures
Authors: Blease Robert , M. Kanlić Enes
Published: May 2018

The large spectrum of open fractures is an amalgamation of injuries with the single variable in common of communication of the fractured bone with the outside environment, and thus an increased risk for infection. Contributing to the presence of bacteria within the fracture site is devascularized soft tissue, the degree of which can be directly attributed to the amount of energy imparted to the tissues. The currently used classification system aids in defining the degree of severity of these injuries and their subsequent risk for infection. The basic management principal for all of these injury patterns remains essentially the same, however: prevention of infection through debridement, wound management, antibiotic usage, and fracture stabilization. Frequently multiple surgical procedures will be required in order to obtain an infection free, united fracture with adequate soft tissue coverage (1).
Obesity biological and psychological aspect
Authors: Fišeković Saida
Published: May 2018

There is no unique pattern to deal with obesity unless is presented as complex of biological and psychological factors. A lot of studies deal with only one side of it. This work shows both sides and discusses about all relevant factors, which are involved in pathogenesis of obesity. This is only way for finding better approaches for treatment and understandings for this issue.