bluuebunny/crossref_metadata_2025 huggingface dataset:
Differential value of diffusion kurtosis imaging and intravoxel incoherent motion in benign and malignant solitary pulmonary lesions
Authors: Xiang Lu , Yang Hong , Qin Yu , Wen Yun , Liu Xue , Zeng Wen-Bing
Published: January 2023

Objective

To investigate the diagnostic value of diffusion kurtosis imaging (DKI) and intravoxel incoherent motion (IVIM) whole-lesion histogram parameters in differentiating benign and malignant solitary pulmonary lesions (SPLs).

Materials and Methods

Patients with SPLs detected by chest CT examination and with further routine MRI, DKI and IVIM-DWI functional sequence scanning data were recruited. According to the pathological results, SPLs were divided into a benign group and a malignant group. Independent samples t tests (normal distribution) or Mann‒Whitney U tests (nonnormal distribution) were used to compare the differences in DKI (Dk, K), IVIM (D, D*, f) and ADC whole-lesion histogram parameters between the benign and malignant SPL groups. The receiver operating characteristic (ROC) curve was used to evaluate the diagnostic efficiency of the histogram parameters and determine the optimal threshold. The area under the curve (AUC) of each histogram parameter was compared by the DeLong method. Spearman rank correlation was used to analyze the correlation between histogram parameters and malignant SPLs.

Results

Most of the histogram parameters for diffusion-related values (Dk, D, ADC) of malignant SPLs were significantly lower than those of benign SPLs, while most of the histogram parameters for the K value of malignant SPLs were significantly higher than those of benign SPLs. DKI (Dk, K), IVIM (D) and ADC were effective in differentiating benign and malignant SPLs and combined with multiple parameters of the whole-lesion histogram for the D value, had the highest diagnostic efficiency, with an AUC of 0.967, a sensitivity of 90.00% and a specificity of 94.03%. Most of the histogram parameters for the Dk, D and ADC values were negatively correlated with malignant SPLs, while most of the histogram parameters for the K value were positively correlated with malignant SPLs.

Conclusions

DKI (Dk, K) and IVIM (D) whole-lesion histogram parameters can noninvasively distinguish benign and malignant SPLs, and the diagnostic performance is better than that of DWI. Moreover, they can provide additional information on SPL microstructure, which has important significance for guiding clinical individualized precision diagnosis and treatment and has potential clinical application value.
Case report: A case of classic hairy cell leukemia with CNS involvement treated with vemurafenib
Authors: Johnson Anna E. , Raju Athul Raj , Jacob Aasems , Hildebrandt Gerhard C.
Published: January 2023

Hairy cell leukemia (HCL) is a rare mature B-cell lymphoproliferative disorder and most often presents as classic hairy cell leukemia. This entity is characterized by an indolent course and the presence of the BRAF V600E mutation. We report the case of an 80-year-old man with a history of classical hairy cell leukemia who presented with fatigue, dizziness, shortness of breath, blurring of vision, and headache. His initial diagnosis was 9 years prior, and he received treatments with cladribine, pentostatin, and rituximab. The workup showed an elevated white blood cell count with atypical lymphocytes, anemia, and thrombocytopenia. A peripheral blood smear confirmed HCL relapse, and a magnetic resonance imaging (MRI) of the brain showed diffuse, nonenhancing masses in the supratentorial and infratentorial regions of the brain. He was initiated on treatment with vemurafenib, with improvements in his white blood cell count and a recovery of his platelet count and hemoglobin. A repeat MRI of the brain after 3 months showed complete resolution of the lesions. Vemurafenib was discontinued after 6 months, with bone marrow biopsy showing no evidence of residual hairy cell leukemia. There have only been limited reports of HCL involvement in the central nervous system in the literature. Due to the rarity of the condition, it is not clear which treatments can be effective for intracranial disease control. Our report shows the successful use of vemurafenib, resulting in complete remission of relapsed HCL with CNS involvement.
Negotiation of the global grid inspection UAV with random delay uncertainty in an information communication network based on a robust fault tolerance mechanism
Authors: Shen Jie , Dong Wen qi , Wang Zhi-fang , Wang Jing , Wang Yang , Liu Han min , Li Haiyan
Published: January 2023

To accurately simulate the interference mechanism of information communication between unmanned aerial vehicles (UAVs) in the future global grid system, a type of control based on dynamic simulation of the satellite communication network and robust fault tolerance with a stochastic delay uncertain network system is proposed. Based on the imaginary future of the global energy Internet, with unknown information and communication interference, we established a UAV model from sensor to actuator network delay using a robust, fault-tolerant control algorithm and a satellite communication network model that combined the controller’s mathematical model. The simulation results showed improved power transmission capability and communication coverage ability of UAVs by using the network fault-tolerant control mechanism with uncertain network delay and information communication interference. The stability and anti-interference performance was also significantly improved. This algorithm provides a strategy for the future development of global energy Internet.
Green synthesis of hyaluronic acid coated, thiolated chitosan nanoparticles for CD44 targeted delivery and sustained release of Cisplatin in cervical carcinoma
Authors: Kousar Kousain , Naseer Faiza , Abduh Maisa S. , Kakar Salik , Gul Rabia , Anjum Sadia , Ahmad Tahir
Published: January 2023

Cervical carcinoma is one of the most prevalent gynecological cancers throughout the world. Cisplatin is used as first line chemotherapy for treatment of cervical cancer, but it comes with plethora of side effects. The aim of this study was to develop hyaluronic acid coated, thiolated chitosan nanocarriers using green synthesis approach, for CD44 targeted delivery and sustained release of Cisplatin in cervical cancer cells. After synthesis through ionic gelation method, Zeta analysis showed that the nanoparticle size was 265.9 nm with a zeta potential of +22.3 mV and .226 PDI. SEM and TEM analysis confirmed the spherical shape and smooth surface of nanoparticles. FTIR and XRD showed the presence of characteristic functional groups, successful encapsulation of drug, and crystalline nature of nanoparticles respectively. Drug loading and entrapment efficiency were calculated to be 70.1% ± 1.2% and 45% ± .28% respectively. Analysis of in vitro drug release kinetics showed that drug release followed the Higuchi model at pH 6.8 and 7.4 and Cisplatin release for up to 72 h confirmed sustained release. In vitro analysis on cervical cancer cells HeLa and normal cervical epithelial cells HCK1T was done through cell morphology analysis, trypan blue assay (concentration range of 10–80 μg/ml), and MTT cytotoxic assay (concentration range of 10–90 μg/ml). The results showed a higher cytotoxic potential of HA coated, thiolated chitosan encapsulated Cisplatin (HA-ThCs-Cis NP) nanoformulation as compared to pure Cisplatin in HeLa while in HCK1T, pure Cisplatin showed much higher toxicity as compared to HA-ThCs-Cis nanoformulation. These findings suggest that CD44 targeted delivery system can be a useful approach to minimize offtarget toxicities, give sustained release and better cellular uptake in cancer cells.
Case Report: Auricular vagus nerve stimulation possibly alleviates COVID-19 disease on a high-risk patient
Authors: Széles József Constantin , Lucny Felix , Tyercha Alexander , Kaniusas Eugenijus , Neumayer Christoph
Published: January 2023

Introduction: SARS-CoV-2 is a highly contagious virus that was identified as the cause of COVID-19 disease in early 2020. The infection is clinically similar to interstitial pneumonia and acute respiratory distress syndrome (ARDS) and often shows cardiovascular damage. Patients with cardiovascular risk factors are more prone to COVID-19 disease and their sequelae. Due to the anti-inflammatory effect and the improvement in pulmonary function, auricular vagus nerve stimulation (aVNS) therapy might alleviate a COVID-19 infection.

Patient and Methods: A high-risk patient with cardiovascular diseases and Implantable Cardioverter Defibrillator (ICD), type 2 diabetes and peripheral arterial disease IV, according to Rutherford`s classification, became infected with COVID-19. The patient underwent wound surgery because of an infected necrosis with a methicillin-resistant Staphylococcus aureus (MRSA) of his small toe and was already on aVNS therapy to relieve his leg pain and improve microcirculation. AVNS was performed with the AuriStim device (Multisana GmbH, Austria), which stimulates vagally innervated regions of the auricle by administering electrical stimulation via percutaneous electrodes for 6 weeks.

Results: The multimorbid high-risk patient, who was expected to go through a severe course of the COVID-19 disease, showed hardly any symptoms during ongoing aVNS therapy, while other family members, being much younger and healthy suffered from a more serious course with headache, pneumonia and general weakness.

Conclusion: The auricular vagus nerve stimulation is a clinically tested and safe procedure and might represent an alternative and effective way of treating COVID-19 disease. Nevertheless, due to several limitations of this case report, randomized controlled studies are needed to evaluate the efficacy of aVNS therapy on COVID-19 disease.
Variable humic product effects on maize structural biochemistry across annual weather patterns and soil types in two Iowa (U.S.A.) production fields
Authors: Olk D. C. , Dinnes D. L. , Hatfield R. D. , Scoresby J. R. , Darlington J. W.
Published: January 2023

Agronomic benefits of humic product application to crops are receiving increasing attention, though underlying biochemical changes remain unexplored, especially in field settings. In this study, maize (Zea mays L.) concentrations of 11 phenol and five carbohydrate monomers were determined in whole plant stover (four growing seasons) and roots (two growing seasons) at physiological maturity for two rainfed fields in Iowa (USA) having humic product applications. Stover and root tissues tended toward greater phenol concentrations in a drier upland transect but greater carbohydrate concentrations in a wetter lowland transect. Two humic treatments further accentuated these trends in upland roots. Their phenol content increased significantly with humic application in the droughtier season of root sampling (2013). Phenol increases above the unamended control averaged 20% for each monomer. Total phenols increased above the control by 12% and 19% for the two humic treatments. Five carbohydrate monomers in the upland roots did not respond to humic application. In the second year of root sampling (2014), which had abundant rainfall, upland root phenols did not respond substantively to humic application, but root carbohydrates increased on average by 11 or 20% for the two humic treatments compared to the control, reaching significance (P< 0.10) in 7 of 10 cases. Upland stover phenol concentrations responded differently to humic product application in each of four years, ranging from numeric increases in the droughtiest year (2012) to significant decreases with abundant rainfall (2014). In the lowland transect, root phenols and carbohydrates and stover phenols responded inconsistently to humic application in four years. Stover carbohydrates did not respond consistently to humic application in either transect. The phenols that were more responsive to humic application or to droughtier conditions included p-coumaric acid and syringaldehyde, which are heavily involved in late-season maize lignification. In summary, humic product application further promoted root lignification, a natural response to drought. Yet under non-drought conditions it promoted root carbohydrate production. Carbohydrate production might be the intrinsic plant response to humic product application in stress-free conditions. These results indicate complex interactions in field conditions between plant biochemistry, environmental signals, and the humic product.
Isolation of high-purity and high-stability exosomes from ginseng
Authors: Jang Jinwoo , Jeong Haewon , Jang Eunjae , Kim Eungpil , Yoon Youngdae , Jang Sujeong , Jeong Han-Seong , Jang Geupil
Published: January 2023

Exosomes are nano-sized extracellular vesicles that regulate cell growth and defense by delivering bioactive cellular constituents. They are a promising material for biomedical and cosmetic utilization, especially in medicinal crops such as ginseng. One main hurdle to their usage is the need for a method to isolate stable exosomes with high purity. In this study, we first tested two methods to isolate exosomes from ginseng: ultracentrifugation, the most widely used method; and the ExoQuick system, a polymer-based exosome precipitation approach. We also designed and tested a third method in which we combined ultracentrifugation and ExoQuick methods. Size distribution analysis revealed that the exosome isolation purity by the ultracentrifugation and ExoQuick methods alone were 34.1% and 59.7%, respectively, while the combination method greatly improved exosome isolation purity (83.3%). Furthermore, we found that the combination method also increases the colloidal stability of isolated ginseng exosomes, and the increase was almost double that of the ultracentrifugation method. Lastly, we showed that the combination method can also be used to isolate high-purity and high-stability exosomes from the model plant Arabidopsis. Overall, our findings indicate that the combination method is suitable to isolate high-purity and high-stability exosomes from plants including ginseng.
Genome-wide identification and expression analysis of two-component system genes in sweet potato (Ipomoea batatas L.)
Authors: Huo Ruxue , Zhao Yanshu , Liu Tianxu , Xu Meng , Wang Xiaohua , Xu Ping , Dai Shengjie , Cui Xiaoyu , Han Yonghua , Liu Zhenning , Li Zongyun
Published: January 2023

Two-component system (TCS), which comprises histidine kinases (HKs), histidine phosphotransfer proteins (HPs), and response regulators (RRs), plays essential roles in regulating plant growth, development, and response to various environmental stimuli. TCS genes have been comprehensively identified in various plants, while studies on the genome-wide identification and analysis of TCS in sweet potato were still not reported. Therefore, in this study, a total of 90 TCS members consisting of 20 HK(L)s, 11 HPs, and 59 RRs were identified in the genome of Ipomoea batatas. Furthermore, their gene structures, conserved domains, and phylogenetic relationships were analyzed in detail. Additionally, the gene expression profiles in various organs were analyzed, and response patterns to adverse environmental stresses were investigated. The results showed that these 90 TCS genes were mapped on 15 chromosomes with a notably uneven distribution, and the expansion of TCS genes in sweet potato was attributed to both segmental and tandem duplications. The majority of the TCS genes showed distinct organ-specific expression profiles, especially in three types of roots (stem roots, fibrous roots, tuberous roots). Moreover, most of the TCS genes were either induced or suppressed upon treatment with abiotic stresses (drought, salinity, cold, heat) and exogenous phytohormone abscisic acid (ABA). In addition, the yeast-two hybrid system was used to reveal the HK-HP-RR protein-protein interactions. IbHP1, IbHP2, IbHP4, and IbHP5 could interact with three HKs (IbHK1a, IbHK1b, and IbHK5), and also interact with majority of the type-B RRs (IbRR20–IbRR28), while no interaction affinity was detected for IbHP3. Our systematic analyses could provide insights into the characterization of the TCS genes, and further the development of functional studies in sweet potato.
Increasing basal nitrogen fertilizer rate improves grain yield, quality and 2-acetyl-1-pyrroline in rice under wheat straw returning
Authors: Wang Jun , Qiu Yuanyuan , Zhang Xingyu , Zhou Zhou , Han Xian , Zhou Yang , Qin Li , Liu Kun , Li Siyu , Wang Weilu , Chen Yun , Yang Jianchang , Liu Lijun
Published: January 2023

Straw returning plays an essential role in crop yields and the sustainable development of agriculture. However, the effects and mechanisms of nitrogen (N) fertilizer management on grain yield, quality and aroma substance 2-acetyl-1-pyrroline (2-AP) content under wheat straw returning are still unclear. In this field experiment, two japonica rice cultivars were used as materials, wheat straw non-returning (NS) and wheat straw full returning (WS) were designed coupled with two N application ratios, namely basal fertilizer: tiller fertilizer: panicle fertilizer =5:1:4 (local farmers’ fertilizer practice, LFP) and 7:1:2 (increasing basal fertilizer rate, IBF) under the total N application rate of 270 kg ha-1. The effects of the four treatment combinations (NS-LFP, NS-IBF, WS-LFP, WS-IBF) on yield, cooking and eating quality, and 2-AP content in rice were investigated. The two-year (2020, 2021) results showed that: 1) WS-IBF significantly increased the number of panicles and grains per panicle, leading to the increase in grain yield by 6.67%–12.21%, when compared with NS-LFP, NS-IBF and WS-LFP. 2) WS-IBF enhanced the taste value, peak viscosity, breakdown value, the ratio of amylopectin to amylose, and the ratio of glutelin to prolamin while reducing the setback value and amylose content of rice flour. 3) Compared with NS, WS increased the activities of proline dehydrogenase and ornithine transaminase, the synthetic precursors of 2-AP, and finally increased 2-AP content in rice grains. WS-IBF slightly decreased 2-AP content, but there was no significant difference with WS-LFP. The above results indicated that adjusting the N regime and increasing basal N fertilizer rate under wheat straw returning is conducive to improving grain yield, cooking and eating quality, and 2-AP content in rice.
Assessing the association between subjective evaluation of space qualities and physiological responses through cinematic environments’ emotion-eliciting stimuli
Authors: Sakhaei Hamidreza , Gu Ning , Looha Mehdi Azizmohammad
Published: January 2023

Objectives

Human perception of the built environment affects emotional and physiological states. This research focused on the association between evaluating a space’s visual qualities and physiological responses by mediating film contents to indicate the association between physiological indicators and assessing the quality of space in the presence of environmental stimuli.

Method

Data collection was conducted using a psychological questionnaire and physiological indicators of heart rate (HR), blood pressure (BP), skin resistance level (SRL), and body temperature (BT) during the film screening. The ANOVA was conducted to compare different variables in the three films alongside linear regression to analyze the impact of variables on space quality. Spearman correlation coefficient analyses were performed to find the association between variables.

Results

The descriptive statistics showed significant changes in psychological and physiological variables in films. Associations between the NAQ factor and physiological changes in HR, SBP, and DBP factors were significant. The results derived from the simple and multiple linear regressions depicted the significant impact of physiological factors on HR and BP on perceiving the quality of space.

Conclusion

It was concluded that physiological changes caused by emotional arousal could be strongly associated with psychological assessments. Stimuli-affected video contents illustrating architectural spaces could efficiently extract the impact of physiological states and human cognitive responses to the space quality. Physiological characteristics related to the space appraisal could help realize the human-environment interaction in a multi-layered approach to the built environment and spatial cognition.
The facilitating effect of identical objects in visual working memory
Authors: Ren Guofang , Ma Nan , Lei Ming
Published: January 2023

According to the associative network of memory representations proposed by embedded processes models, the links between related memory representations were automatically established, which rendered these representations more easily activated. The present study adopted color recall tasks to explore whether the memory performance of identical objects was enhanced via the strengthening links between them, producing facilitating effect of identical objects. In Experiment 1, the number of identical items was manipulated. The results evidenced the facilitating effect, which was positively related to the number of identical objects. Experiment 2 modulated the spatial location of identical objects, which suggested that the facilitating effect was absent when two pairs of identical objects were located diagonally. Furthermore, Experiment 3 suggested that the facilitating effect was observed for the identical items which were presented in the second and fourth quadrants, rather than the first and third quadrants. Together, these results evidenced the facilitating effect of identical objects, which, however, was affected by spatial bias.
Does language make people more prosocial? The influence of Mandarin proficiency on donation behavior
Authors: Wang Qiang , Yu Laihui , Zhang Ruilin
Published: January 2023

Both the effects of language proficiency on individual outcomes, and the influencing factors of individual donation arouse wide concern, but researchers have hardly probed into the relationship between language proficiency and donation behavior. Using the data from the 2012 China General Social Survey (CGSS) and the binary logistic regression model as the benchmark model, this study empirically examines the influence and mechanism of language proficiency on donation behavior. It is revealed that Mandarin proficiency has significant positive influence on individual donation behavior. According to the results of the variable substitution practice and the instrumental variable regression based on the two-stage least square model, the above conclusion remains robust. The heterogeneity test shows that Mandarin proficiency of male, southern and rural residents has more obvious impact on donation behavior. The multiple intermediary effect test indicates that perceived social responsibility and subjective social status partially mediate the relationship between Mandarin proficiency and donation behavior. Therefore, it indicates that language proficiency has a prosocial effect, which makes people more prosocial. This study contributes to the literature on donation behavior by examining the influencing mechanism of Mandarin proficiency on individual donation, and further the effects of language proficiency on individual outcomes, thereby providing theoretical and empirical support for the formulation of policies for the promotion of Mandarin and social donation in China.
Variation in morpho-lexical development within and between diagnoses in children with neurodevelopmental disorders
Authors: Foster-Cohen Susan , Macrae Toby , Newbury Jayne
Published: January 2023

While primary diagnosis is only one aspect of the presentation of a child with neurodevelopmental delay/disorder, the degree to which early expressive language reflects diagnostic divisions must be understood in order to reduce the risk of obscuring clinically important differences and similarities across diagnoses. We present original data from the New Zealand MacArthur-Bates Communicative Development Inventory (NZCDI) from 88 English-speaking children aged 2;6 to 5;6 years receiving multidisciplinary intervention within a single family-centered program. The children had one of six pediatrician-assigned genetic or behaviorally determined diagnoses: Down syndrome (DS); motor disorders (cerebral palsy and developmental coordination disorder); global development delay; disorders of relating and communicating (R&C); other genetically defined diagnoses; or language delay due to premature (PREM) birth. Morphological and lexical development were compared within and across diagnostic groups, using both data visualization and mixed-effects modeling. Groups varied in the amount of variation within and between them, but only prematurity reached significance, in interaction with age, as a predictor of morpho-lexical scores. Further analysis of longitudinal data available from a subset of the sample (n = 62) suggested that individual trajectories of vocabulary growth could not be reliably predicted by diagnosis. Moreover, the distribution of word types (nouns, predicates, etc.) only distinguished PREM children with language delay from those with DS and those in the R&C group. There were strong similarities in early morpho-lexical development across these clinical populations, with some differences. These findings align with research and clinical approaches which accommodate individual variation within diagnosis, and broad similarities across diagnostic groups.
A comparison of temporal pathways to self-harm in young people compared to adults: A pilot test of the Card Sort Task for Self-harm online using Indicator Wave Analysis
Authors: Lockwood Joanna , Babbage Camilla , Bird Katherine , Thynne Imogen , Barsky Andrey , Clarke David D. , Townsend Ellen
Published: January 2023

Background

Self-harm is complex, multifaceted, and dynamic, typically starts in adolescence, and is prevalent in young people. A novel research tool (the Card Sort Task for Self-harm; CaTS) offers a systematic approach to understanding this complexity by charting the dynamic interplay between multidimensional factors in the build-up to self-harm. Sequential analysis of CaTS has revealed differences in key factors between the first and the most recent episode of self-harm in adolescence. Rates of self-harm typically decline post-adolescence, but self-harm can continue into adulthood. A comparison between factors linked to self-harm in young people vs. adults will inform an understanding of how risk unfolds over time and clarify age-specific points for intervention. A pilot online adaptation (CaTS-online) and a new method (Indicator Wave Analysis; IWA) were used to assess key factors in the build-up to self-harm.

Methods

Community-based young people (n = 66; 18–25 years, M = 21.4; SD = 1.8) and adults (n = 43; 26–57 years, M = 35; SD = 8.8) completed CaTS-online, documenting thoughts, feelings, events, and behaviours over a 6-month timeline for the first ever and most recent self-harm. A notable interdependence between factors and time points was identified using IWA.

Results

Positive emotion at and immediately after self-harm exceeded the threshold for both groups for both episodes. Feeling better following self-harm was more pronounced for the first-ever episodes. Impulsivity was an important immediate antecedent to self-harm for both groups at both episodes but most markedly for young people. Acquired capability was notable for adults’ most recent episodes, suggesting this develops over time. Burdensomeness was only more notable for adults and occurred 1 week prior to a recent episode. Both groups revealed patterns of accessing support that were helpful and unhelpful.

Conclusion

Commonalities and differences in the temporal organisation of factors leading to and following self-harm were identified in young people and adult pathways which shed light on age-specific factors and possible points of intervention. This has implications for clinical support and services around approaches to positive feelings after self-harm (especially for first-ever self-harm), feeling of burdensomeness, impulsivity, and acquired capability leading up to self-harm. Support is provided for card-sort approaches that enable the investigation of the complex and dynamic nature of pathways to self-harm.
TwinXR: Method for using digital twin descriptions in industrial eXtended reality applications
Authors: Tu Xinyi , Autiosalo Juuso , Ala-Laurinaho Riku , Yang Chao , Salminen Pauli , Tammi Kari
Published: January 2023

Digital twins (DTs) and eXtended Reality (XR) are two core technological enablers for engineering in the Metaverse that can accelerate the human-centric Industry 5.0 transformation. The digital twin technology provides a digital representation of a physical asset with data linkages for inspection, monitoring, and prediction of complex processes or systems, while eXtended reality offers real-and-virtual combined environments for human users to interact with machines. However, the synergies between digital twins and eXtended reality remain understudied. This work addresses this research gap by introducing a novel method “TwinXR” that leverages ontology-based descriptions of Digital twins, i.e., digital twin documents, in industrial eXtended reality applications. To ease the use of the TwinXR method, we publish a Unity package that allows data flow and conversion between eXtended reality applications and digital twin documents on the server. Finally, the work applies the TwinXR method in two industrial eXtended reality applications involving overhead cranes and a robot arm to demonstrate the use and indicate the validity of the method. We conclude that the TwinXR method is a promising way to advance the synergies between digital twins and eXtended reality: For eXtended reality, TwinXR enables efficient and scalable eXtended reality development; For digital twins, TwinXR unlocks and demonstrates the potential of digital twins for data interchange and system interoperation. Future work includes introducing more detailed principles of Semantic Web and Knowledge Graph, as well as developing factory-level TwinXR-compatible applications.
Media education and educational commons for youth civic engagement. A case study from the Horizon 2020 project SMOOTH
Authors: Cappello Gianna , Siino Marianna
Published: January 2023

This study presents the preliminary findings of the first round of implementation of a case study included in the Horizon 2020 project SMOOTH. The project's main objective is to introduce and study the emergent paradigm of the educational commons as an alternative system of values and actions for promoting intercultural and intergenerational dialogue and establishing spaces of democratic citizenship that support the development of local communities. Our case study adopts this paradigm with insights derived from the field of media education. Hence, our research questions were as follows: (a) How do young people collectively experience and build the educational commons? (b) How do participants (youth and adults) in educational commons experience peer governance and how do they handle and resolve conflicts? (c) How does the co-creation of a photo-blog as a shared space of work help young people discover and develop a "civic intentionality" in the (digital) public sphere? (d) What are the effects of applying a commons' logic to address inequalities and achieve social inclusion of young people from vulnerable social groups? Fieldwork, framed in an ethnographic and action-research approach, was developed by examining the three dimensions of the notion of educational commons (commoners, commoning practices, and community). Although data collection and analysis are still in progress, our preliminary results allow us to draw some initial reflections on what worked well in the first round and what could hinder the achievement of the project's objectives. We also propose hypotheses for re-designing the second round to overcome the weaknesses that emerged during the first experimental phase and foster its strengths.
A review of instrument techniques to measure magnetospheric cold electrons and ions
Authors: Maldonado Carlos A. , Resendiz Lira Pedro A. , Delzanno Gian L. , Larsen Brian A. , Reisenfeld Daniel B. , Coffey Victoria
Published: January 2023

A review of the instruments and techniques to directly measure the full distributions of the cold-ion and cold-electron populations in the magnetosphere is presented. Relatively few studies have focused on the cold plasma populations of the magnetosphere due to difficulties associated with obtaining measurements. The cold particle populations are defined here as those with total energy approximately <100 eV which is an energy range for which measurements are difficult (regardless of species), but which often make up the bulk of the plasma density. These populations have known and suspected impacts on the structure and dynamics of the magnetosphere but to date have not yet been measured adequately. The lack of accurate measurements cold ion and electron populations through the magnetosphere makes closure of these science questions extremely difficult if not impossible. Reaching closure will require innovations in plasma spectrometers and associated techniques required to obtain high-fidelity measurements of the cold ion and electron populations in the magnetosphere. This paper seeks to review the instruments and techniques that have been used to date and present possible options for future missions.
Multispacecraft wave analysis of current sheet flapping motions in Earth’s magnetotail
Authors: Petrenko Bohdan , Kozak Liudmyla , Kronberg Elena , Akhmetshyn Roman
Published: January 2023

In our work, for the first time, we conducted a comprehensive multispacecraft wave study of flapping current sheet oscillations in Earth’s magnetotail. Measurements taken from the Magnetospheric Multiscale (MMS) mission were analyzed for two flapping events with different morphologies of oscillation behavior: stationary-like and kink-like type. A comparison of the results calculated by the methods of phase difference, wave surveyor, and Multipoint Signal Resonator technique was carried out. For the first time, using observations, it was found that the energy distribution of wavy magnetic field contains complex multi-branch dispersion dependencies on ky and kz. The phase velocities of propagation of flapping oscillations were estimated. The used methods complement each other, and their differences made it possible to assess the presence of non-linear wave packets during kink flapping and the azimuthal asymmetry of the current sheet profile.
Accelerating the transformation to a sustainable food economy by strengthening the sustainable entrepreneurial ecosystem
Authors: Forrest Nigel , Wiek Arnim , Keeler Lauren Withycombe
Published: January 2023

Strengthening the sustainable entrepreneurial ecosystem (SEE), particularly its support functions for small to medium-sized enterprises (SMEs), is increasingly seen as an important means of accelerating the transformation to a sustainable economy. Little is known, however, abouthowto strengthen SEEs. In this article, we evaluate a series of 16 projects intended to develop SEE functioning to accelerate transformation to a sustainable food economy in the Greater Phoenix Area of Arizona. We use an evaluative framework designed around a set of ten SEE support functions to qualitatively assess the baseline state of the SEE, how projects were executed, the effects of these projects, and the overall changes in the SEE that resulted. The findings indicate all but one projects had positive effects on the SEE (nine weak, six medium). In conjunction with other developments, the projects raised the overall SEE performance from the baseline state of two functions being performed at only minimal level, to six functions being performed minimally, and one at a medium level. Insights gained from comparing results across projects suggest tentative guidelines for future practice, which should be useful for SEE stakeholders, including policy makers, economic development agencies, financial institutions, consultants, and educators, interested in strengthening SEEs. Researchers engaging in studies on strengthening SEEs may benefit from the evaluative framework enabling larger cross-case comparisons.
Surgical outcomes of spinal cavernous malformations: A retrospective study of 98 patients
Authors: Liao Dengyong , Wang Ruoran , Shan Baoyin , Chen Haifeng
Published: January 2023

Objective

Spinal cord cavernous malformation (SCCM) is a rare vascular lesion, and the treatment strategy remains controversial at present. The goal of this retrospective study was to analyze the surgical outcomes of the SCCM and to find more appropriate treatment strategies for a better prognosis.

Method

A retrospective review of 98 patients with SCCM from 2009 to 2018 was conducted at the neurosurgical center of our hospital. Neurological function was assessed using the American Spinal Injury Association (ASIA) impairment scale. Clinical features were analyzed using the multivariable logistic regression.

Results

Ninety-eight patients with SCCM were included, of whom 36% were female and 64% male. The mean age was 41.6 years; and family history was reported in 8% of patients. Definite hemorrhage was found in 6%. Before surgery, the neurological status was Grade A in 2%, Grade B in 2%, Grade C in 12%, Grade D in 54%, and Grade E in 30% of the patients. 83% (81/98) patients had long-term follow-up, of whom, 42% had improved, 51% were stable and 7% had deteriorated. Patients with dorsal or superficial lesions showed better improvement than those with ventral or lateral deep lesions. Those with symptoms lasting less than three months had higher rates of improvement than those with symptoms lasting more than three months. However, there was no significant difference in prognosis between hemilaminectomy and laminectomy.

Conclusion

These results suggest that surgical strategies should be preferred for severe symptomatic SCCMs if total resection can be achieved, thereby avoiding the risk of severe complications with subsequent lesion hemorrhage. Earlier (usually within 3 months of symptom duration) surgical resection generally may lead to a better prognosis. For ventral or lateral deep SCCMs, the surgical strategy should be considered more carefully.
An assessment of enhanced biosecurity interventions and their impact on porcine reproductive and respiratory syndrome virus outbreaks within a managed group of farrow-to-wean farms, 2020–2021
Authors: Havas Karyn A. , Brands Lisa , Cochrane Roger , Spronk Gordon D. , Nerem Joel , Dee Scott A.
Published: January 2023

Introduction

Porcine reproductive and respiratory syndrome virus (PRRSV) has been a challenge for the U.S. swine industry for over 30 years, costing producers more than $600 million annually through reproductive disease in sows and respiratory disease in growing pigs. In this study, the impact of enhanced biosecurity practices of site location, air filtration, and feed mitigation was assessed on farrow-to-wean sites managed by a large swine production management company in the Midwest United States. Those three factors varied in the system that otherwise had implemented a stringent biosecurity protocol on farrow-to-wean sites. The routine biosecurity followed commonplace activities for farrow-to-wean sites that included but were not limited to visitor registration, transport disinfection, shower-in/shower-out procedures, and decontamination and disinfection of delivered items and were audited.

Methods

Logistic regression was used to evaluate PRRSV infection by site based on the state where the site is located and air filtration use while controlling for other variables such as vaccine status, herd size, and pen vs. stall. A descriptive analysis was used to evaluate the impact of feed mitigation stratified by air filtration use.

Results

Sites that used feed mitigates as additives in the diets, air filtration of barns, and that were in less swine-dense areas appeared to experience fewer outbreaks associated with PRRSV infection. Specifically, 23.1% of farms that utilized a feed mitigation program experienced PRRSV outbreaks, in contrast to 100% of those that did not. Sites that did not use air filtration had 20 times greater odds of having a PRRSV outbreak. The strongest protective effect was found when both air filtration and feed mitigation were used. Locations outside of Minnesota and Iowa had 98.5–99% lesser odds of infection as well.

Discussion

Enhanced biosecurity practices may yield significant protective effects and should be considered for producers in swine-dense areas or when the site contains valuable genetics or many pigs.
Soft Complete Continuity and Soft Strong Continuity in Soft Topological Spaces
Authors: Al Ghour Samer
Published: January 2023

In this paper, we introduce soft complete continuity as a strong form of soft continuity and we introduce soft strong continuity as a strong form of soft complete continuity. Several characterizations, compositions, and restriction theorems are obtained. Moreover, several preservation theorems regarding soft compactness, soft Lindelofness, soft connectedness, soft regularity, soft normality, soft almost regularity, soft mild normality, soft almost compactness, soft almost Lindelofness, soft near compactness, soft near Lindelofness, soft paracompactness, soft near paracompactness, soft almost paracompactness, and soft metacompactness are obtained. In addition to these, the study deals with the correlation between our new concepts in soft topology and their corresponding concepts in general topology; as a result, we show that soft complete continuity (resp. soft strong continuity) in soft topology is an extension of complete continuity (resp. strong continuity) in soft topology.
Tailored Pre-Lithiation Using Melt-Deposited Lithium Thin Films
Authors: Schönherr Kay , Pöthe Markus , Schumm Benjamin , Althues Holger , Leyens Christoph , Kaskel Stefan
Published: January 2023

The user demands lithium-ion batteries in mobile applications, and electric vehicles request steady improvement in terms of capacity and cycle life. This study shows one way to compensate for capacity losses due to SEI formation during the first cycles. A fast and simple approach of electrolyte-free direct-contact pre-lithiation leads to targeted degrees of pre-lithiation for graphite electrodes. It uses tailor-made lithium thin films with 1–5 µm lithium films produced by lithium melt deposition as a lithium source. These pre-lithiated graphite electrodes show 6.5% capacity increase after the first cycles in NCM full cells. In this study, the influence of the pre-lithiation parameters—applied pressure, temperature and pressing time—on the pre-lithiation process is examined.
In-Silico Lead Druggable Compounds Identification against SARS COVID-19 Main Protease Target from In-House, Chembridge and Zinc Databases by Structure-Based Virtual Screening, Molecular Docking and Molecular Dynamics Simulations
Authors: Ghufran Mehreen , Ullah Mehran , Khan Haider Ali , Ghufran Sabreen , Ayaz Muhammad , Siddiq Muhammad , Abbas Syed Qamar , Hassan Syed Shams ul , Bungau Simona
Published: January 2023

Pharmacological strategies to lower the viral load among patients suffering from severe diseases were researched in great detail during the SARS-CoV-2 outbreak. The viral protease Mpro (3CLpro) is necessary for viral replication and is among the main therapeutic targets proposed, thus far. To stop the pandemic from spreading, researchers are working to find more effective Mpro inhibitors against SARS-CoV-2. The 33.8 kDa Mpro protease of SARS-CoV-2, being a nonhuman homologue, has the possibility of being utilized as a therapeutic target against coronaviruses. To develop drug-like compounds capable of preventing the replication of SARS-main CoV-2’s protease (Mpro), a computer-aided drug design (CADD) approach is extremely viable. Using MOE, structure-based virtual screening (SBVS) of in-house and commercial databases was carried out using SARS-CoV-2 proteins. The most promising hits obtained during virtual screening (VS) were put through molecular docking with the help of MOE. The virtual screening yielded 3/5 hits (in-house database) and 56/66 hits (commercial databases). Finally, 3/5 hits (in-house database), 3/5 hits (ZINC database), and 2/7 hits (ChemBridge database) were chosen as potent lead compounds using various scaffolds due to their considerable binding affinity with Mpro protein. The outcomes of SBVS were then validated using an analysis based on molecular dynamics simulation (MDS). The complexes’ stability was tested using MDS and post-MDS. The most promising candidates were found to exhibit a high capacity for fitting into the protein-binding pocket and interacting with the catalytic dyad. At least one of the scaffolds selected will possibly prove useful for future research. However, further scientific confirmation in the form of preclinical and clinical research is required before implementation.
Comparing Remote Speckle Plethysmography and Finger-Clip Photoplethysmography with Non-Invasive Finger Arterial Pressure Pulse Waves, Regarding Morphology and Arrival Time
Authors: Herranz Olazabal Jorge , Wieringa Fokko , Hermeling Evelien , Van Hoof Chris
Published: January 2023

Objective: The goal was to compare Speckle plethysmography (SPG) and Photoplethysmography (PPG) with non-invasive finger Arterial Pressure (fiAP) regarding Pulse Wave Morphology (PWM) and Pulse Arrival Time (PAT). Methods: Healthy volunteers (n = 8) were connected to a Non-Invasive Blood Pressure (NIBP) monitor providing fiAP pulse wave and PPG from a clinical transmission-mode SpO2 finger clip. Biopac recorded 3-lead ECG. A camera placed at a 25 cm distance recorded a video stream (100 fps) of a finger illuminated by a laser diode at 639 nm. A chest belt (Polar) monitored respiration. All signals were recorded simultaneously during episodes of spontaneous breathing and paced breathing. Analysis: Post-processing was performed in Matlab to obtain SPG and analyze the SPG, PPG and fiAP mean absolute deviations (MADs) on PWM, plus PAT modulation. Results: Across 2599 beats, the average fiAP MAD with PPG was 0.17 (0–1) and with SPG 0.09 (0–1). PAT derived from ECG–fiAP correlated as follows: 0.65 for ECG–SPG and 0.67 for ECG–PPG. Conclusion: Compared to the clinical NIBP monitor fiAP reference, PWM from an experimental camera-derived non-contact reflective-mode SPG setup resembled fiAP significantly better than PPG from a simultaneously recorded clinical transmission-mode finger clip. For PAT values, no significant difference was found between ECG–SPG and ECG–PPG compared to ECG–fiAP.