bluuebunny/crossref_metadata_2025 huggingface dataset:
Neuropsychology of Aesthetic Judgment of Ambiguous and Non-Ambiguous Artworks
Authors: Boccia Maddalena , Barbetti Sonia , Piccardi Laura , Guariglia Cecilia , Giannini Anna
Published: March 2017

Several affective and cognitive processes have been found to be pivotal in affecting aesthetic experience of artworks and both neuropsychological as well as psychiatric symptoms have been found to affect artistic production. However, there is a paucity of studies directly investigating effects of brain lesions on aesthetic judgment. Here, we assessed the effects of unilateral brain damage on aesthetic judgment of artworks showing part/whole ambiguity. We asked 19 unilaterally brain-damaged patients (10 left and 9 right brain damaged patients, respectively LBDP and RBDP) and 20 age- and education-matched healthy individuals (controls, C) to rate 10 Arcimboldo’s ambiguous portraits (AP), 10 realistic Renaissance portraits (RP), 10 still life paintings (SL), and 10 Arcimboldo’s modified portraits where only objects/parts are detectable (AO). They were also administered a Navon task, a facial recognition test, and evaluated on visuo-perceptual and visuo-constructional abilities. Patients included in the study did not show any deficits that could affect the capability to explore and enjoy artworks. SL and RP was not affected by brain damage regardless of its laterality. On the other hand, we found that RBDP liked AP more than the C participants. Furthermore, we found a positive correlation between aesthetic judgment of AP and visuo-perceptual skills even if the single case analyses failed to find a systematic association between neuropsychological deficits and aesthetic judgment of AP. On the whole, the present data suggest that a right hemisphere lesion may affect aesthetic judgment of ambiguous artworks, even in the absence of exploration or constructional deficits.
Communication Matters: Exploring the Intersection of Family and Practitioner End of Life Communication
Authors: Omilion-Hodges Leah , Swords Nathan
Published: March 2017

After establishing a baseline understanding of some of the factors that influence and shape family end of life communication, empirical research centered on the communication tendencies of nationally-recognized palliative care clinicians is presented. Because death is no longer confined to the bedroom and individuals are increasingly turning to hospitals and health care institutes to assist with end of life, the role of palliative care practitioners is vital. To that end, common communication-rooted issues that may transpire among various medical personnel are explored. Focus on a shared underlying tension—care vs. cure—links the findings between family and palliative care clinician communication regarding end of life. Practical communication solutions and suggestions are offered to facilitate productive and mindful end of life communication between and among family members and health care practitioners.
An Accurate Computational Tool for Performance Estimation of FSO Communication Links over Weak to Strong Atmospheric Turbulent Channels
Authors: Katsilieris Theodore D. , Latsas George P. , Nistazakis Hector E. , Tombras George S.
Published: March 2017

The terrestrial optical wireless communication links have attracted significant research and commercial worldwide interest over the last few years due to the fact that they offer very high and secure data rate transmission with relatively low installation and operational costs, and without need of licensing. However, since the propagation path of the information signal, i.e., the laser beam, is the atmosphere, their effectivity affects the atmospheric conditions strongly in the specific area. Thus, system performance depends significantly on the rain, the fog, the hail, the atmospheric turbulence, etc. Due to the influence of these effects, it is necessary to study, theoretically and numerically, very carefully before the installation of such a communication system. In this work, we present exactly and accurately approximate mathematical expressions for the estimation of the average capacity and the outage probability performance metrics, as functions of the link’s parameters, the transmitted power, the attenuation due to the fog, the ambient noise and the atmospheric turbulence phenomenon. The latter causes the scintillation effect, which results in random and fast fluctuations of the irradiance at the receiver’s end. These fluctuations can be studied accurately with statistical methods. Thus, in this work, we use either the lognormal or the gamma–gamma distribution for weak or moderate to strong turbulence conditions, respectively. Moreover, using the derived mathematical expressions, we design, accomplish and present a computational tool for the estimation of these systems’ performances, while also taking into account the parameter of the link and the atmospheric conditions. Furthermore, in order to increase the accuracy of the presented tool, for the cases where the obtained analytical mathematical expressions are complex, the performance results are verified with the numerical estimation of the appropriate integrals. Finally, using the derived mathematical expression and the presented computational tool, we present the corresponding numerical results, using common parameter values for realistic terrestrial free space optical communication systems.
Privacy in a Digital, Networked World: Technologies, Implications and Solutions. By Sherali Zeadally and Mohamad Badra. Springer International Publishing: 418 pp.; $51.89; ISBN-10: 3319084690, ISBN-13: 978-3319084695
Authors: Sklavos Nicolas
Published: March 2017

The book entitled Privacy in a Digital, Networked World: Technologies, Implications and Solutions of the series Computer Communications and Networks is the latest published book edited by Sherali Zeadally and Mohamad Badra.[...]
X-ray Structures of Succinimidyl Halobenzoates
Authors: Mamat Constantin , Weiß Daniel Holger , Köckerling Martin
Published: March 2017

The crystal and molecular structures of five succinimidyl halobenzoates are reported. Corresponding derivatives with the respective halo-radionuclide (18F, 76Br, 123I/124I/125I/131I) were prepared and used for the radiolabeling of biologically active (macro-)molecules (peptides, proteins, antibodies) under mild labeling conditions. All compounds were crystalized from petroleum ether/ethyl acetate mixtures.
Detecting Breast Cancer with a Dual-Modality Device
Authors: Padia Kamila , Douglas Tania , Cairncross Lydia , Baasch Roland , Vaughan Christopher
Published: March 2017

Although mammography has been the gold standard for the early detection of breast cancer, if a woman has dense breast tissue, a false negative diagnosis may occur. Breast ultrasound, whether hand-held or automated, is a useful adjunct to mammography but adds extra time and cost. The primary aim was to demonstrate that our second-generation Aceso system, which combines full-field digital mammography (FFDM) and automated breast ultrasound (ABUS) in a single platform, is able to produce improved quality images that provide clinically meaningful results. Aceso was first tested using two industry standards: a Contrast Detail Mammography (CDMAM) phantom to assess the FFDM images, and the CIRS 054GS phantom to evaluate the ABUS images. In addition, 25 women participated in a clinical trial: 14 were healthy volunteers, while 11 were patients referred by the breast clinic at Groote Schuur Hospital. The CDMAM phantom results showed the FFDM results were better than the European Reference (EUREF) standard of “acceptable” and were approaching “achievable”. The ABUS results showed a lateral and axial spatial resolution of 0.5 mm and an adequate depth penetration of 80 mm. Our second-generation Aceso system, with its improved quality of clinical FFDM and ABUS images, has demonstrated its potential for the early detection of breast cancer in a busy clinic.
Symptoms Relevant to Surveillance for Ovarian Cancer
Authors: Ore Robert M. , Baldwin Lauren , Woolum Dylan , Elliott Erika , Wijers Christiaan , Chen Chieh-Yu , Miller Rachel W. , DeSimone Christopher P. , Ueland Frederick R. , Kryscio Richard J. , Nagell John R. van , Pavlik Edward J.
Published: March 2017

To examine how frequently and confidently healthy women report symptoms during surveillance for ovarian cancer. A symptoms questionnaire was administered to 24,526 women over multiple visits accounting for 70,734 reports. A query of reported confidence was included as a confidence score (CS). Chi square, McNemars test, ANOVA and multivariate analyses were performed. 17,623 women completed the symptoms questionnaire more than one time and >9500 women completed it more than one four times for >43,000 serially completed questionnaires. Reporting ovarian cancer symptoms was ~245 higher than ovarian cancer incidence. The positive predictive value (0.073%) for identifying ovarian cancer based on symptoms alone would predict one malignancy for 1368 cases taken to surgery due to reported symptoms. Confidence on the first questionnaire (83.3%) decreased to 74% when more than five questionnaires were completed. Age-related decreases in confidence were significant (p < 0.0001). Women reporting at least one symptom expressed more confidence (41,984/52,379 = 80.2%) than women reporting no symptoms (11,882/18,355 = 64.7%), p < 0.0001. Confidence was unrelated to history of hormone replacement therapy or abnormal ultrasound findings (p = 0.30 and 0.89). The frequency of symptoms relevant to ovarian cancer was much higher than the occurrence of ovarian cancer. Approximately 80.1% of women expressed confidence in what they reported.
A Simple Test for Causality in Volatility
Authors: Chang Chia-Lin , McAleer Michael
Published: March 2017

An early development in testing for causality (technically, Granger non-causality) in the conditional variance (or volatility) associated with financial returns was the portmanteau statistic for non-causality in the variance of Cheng and Ng (1996). A subsequent development was the Lagrange Multiplier (LM) test of non-causality in the conditional variance by Hafner and Herwartz (2006), who provided simulation results to show that their LM test was more powerful than the portmanteau statistic for sample sizes of 1000 and 4000 observations. While the LM test for causality proposed by Hafner and Herwartz (2006) is an interesting and useful development, it is nonetheless arbitrary. In particular, the specification on which the LM test is based does not rely on an underlying stochastic process, so the alternative hypothesis is also arbitrary, which can affect the power of the test. The purpose of the paper is to derive a simple test for causality in volatility that provides regularity conditions arising from the underlying stochastic process, namely a random coefficient autoregressive process, and a test for which the (quasi-) maximum likelihood estimates have valid asymptotic properties under the null hypothesis of non-causality. The simple test is intuitively appealing as it is based on an underlying stochastic process, is sympathetic to Granger’s (1969, 1988) notion of time series predictability, is easy to implement, and has a regularity condition that is not available in the LM test.
Effects of Energy Storage Systems Grid Code Requirements on Interface Protection Performances in Low Voltage Networks
Authors: Bignucolo Fabio , Cerretti Alberto , Coppo Massimiliano , Savio Andrea , Turri Roberto
Published: March 2017

The ever-growing penetration of local generation in distribution networks and the large diffusion of energy storage systems (ESSs) foreseen in the near future are bound to affect the effectiveness of interface protection systems (IPSs), with negative impact on the safety of medium voltage (MV) and low voltage (LV) systems. With the scope of preserving the main network stability, international and national grid connection codes have been updated recently. Consequently, distributed generators (DGs) and storage units are increasingly called to provide stabilizing functions according to local voltage and frequency. This can be achieved by suitably controlling the electronic power converters interfacing small-scale generators and storage units to the network. The paper focuses on the regulating functions required to storage units by grid codes currently in force in the European area. Indeed, even if such regulating actions would enable local units in participating to network stability under normal steady-state operating conditions, it is shown through dynamic simulations that they may increase the risk of unintentional islanding occurrence. This means that dangerous operating conditions may arise in LV networks in case dispersed generators and storage systems are present, even if all the end-users are compliant with currently applied connection standards.
Experimental Results on a Wireless Wattmeter Device for the Integration in Home Energy Management Systems
Authors: Rodrigues Eduardo M. G. , Godina Radu , Shafie-khah Miadreza , Catalão João P. S.
Published: March 2017

This paper presents a home area network (HAN)-based domestic load energy consumption monitoring prototype device as part of an advanced metering system (AMS). This device can be placed on individual loads or configured to measure several loads as a whole. The wireless communication infrastructure is supported on IEEE 805.12.04 radios that run a ZigBee stack. Data acquisition concerning load energy transit is processed in real time and the main electrical parameters are then transmitted through a RF link to a wireless terminal unit, which works as a data logger and as a human-machine interface. Voltage and current sensing are implemented using Hall effect principle-based transducers, while C code is developed on two 16/32-bit microcontroller units (MCUs). The main features and design options are then thoroughly discussed. The main contribution of this paper is that the proposed metering system measures the reactive energy component through the Hilbert transform for low cost measuring device systems.
Development of Brazilian Biodiesel Sector from the Perspective of Stakeholders
Authors: Cardoso Bárbara Françoise , Shikida Pery Francisco Assis , Finco Adele
Published: March 2017

In Brazil, the main program with respect to biodiesel is the National Program of Biodiesel Production and Use (NPBP). It is also considered the regulation mark of biodiesel production in Brazil and its directives are social inclusion and regional development. Considering these directives, this paper aims to analyse the perspective of biodiesel sector stakeholders in Brazil to understand whether NPBP directives are in consonance with the reality of the sector for its development. A questionnaire was created with 48 questions in order to understand the importance of 13 variables for the stakeholders, and the responses were treated by factor analysis (FA). The results showed the existence of a trade-off related to technological advances in biodiesel production that confronts NPBP directives, that is, the biodiesel sector tends not to evolve in terms of the use of advanced technologies. If policies change so as to develop the biodiesel sector using advanced technologies, NPBP should change its directives in order to involve family farmers in another way in the Brazilian economy.
Methodology for Determination of the Number of Equipment Malfunctions Due to Voltage Sags
Authors: Otcenasova Alena , Bodnar Roman , Regula Michal , Hoger Marek , Repak Michal
Published: March 2017

This article deals with the assessment of the reliability of sensitive equipment due to voltage sags. The most frequent problems of power quality are voltage sags. Equipment that cannot withstand short-term voltage sag is defined as sensitive device. Sensitivity of such equipment can be described by the voltage–tolerance curves. A device (generator) to generate voltage sags (also interruptions) with duration at least 1 ms has been designed and developed for this purpose. Equipment sensitive to voltage sags was tested using this generator. Overall, five types of sensitive equipment were tested: personal computers, fluorescent lamps, drives with speed control, programmable logic controllers, and contactors. The measured sensitivity curves of these devices have been used to determine the number of trips (failures) due to voltage sags. Two probabilistic methods (general probability method and cumulative probability method) to determine probability of equipment failure occurrence are used. These methods were applied to real node in the distribution system with its actual performance of voltage sags/swells. The calculations also contain different levels of sensitivity of the sensitive equipment.
Phenotypic Plasticity Explains Response Patterns of European Beech (Fagus sylvatica L.) Saplings to Nitrogen Fertilization and Drought Events
Authors: Dziedek Christoph , Fichtner Andreas , Calvo Leonor , Marcos Elena , Jansen Kirstin , Kunz Matthias , Walmsley David , Von Oheimb Goddert , Härdtle Werner
Published: March 2017

Abstract: Climate and atmospheric changes affect forest ecosystems worldwide, but little is known about the interactive effects of global change drivers on tree growth. In the present study, we analyzed single and combined effects of nitrogen (N) fertilization and drought events (D) on the growth of European beech (Fagus sylvatica L.) saplings in a greenhouse experiment. We quantified morphological and physiological responses to treatments for one‐ and two‐year‐old plants. N fertilization increased the saplings’ aboveground biomass investments, making them more susceptible to D treatments. This was reflected by the highest tissue dieback in combined N and D treatments and a significant N × D interaction for leaf δ13C signatures. Thus, atmospheric N deposition can strengthen the drought sensitivity of beech saplings. One‐year‐old plants reacted more sensitively to D treatments than two‐year‐old plants (indicated by D‐induced shifts in leaf δ13C signatures of one‐year‐old and two‐year‐old plants by +0.5‰ and −0.2‰, respectively), attributable to their higher shoot:root‐ratios (1.8 and 1.2, respectively). In summary, the saplings’ treatment responses were determined by their phenotypic plasticity (shifts in shoot:root‐ratios), which in turn was a function of both the saplings’ age (effects of allometric growth trajectories = apparent plasticity) and environmental impacts (effects of N fertilization = plastic allometry).
Emotion at Stake—The Role of Stake Size and Emotions in a Power-to-Take Game Experiment in China with a Comparison to Europe
Authors: Bosman Ronald , Hennig-Schmidt Heike , Van Winden Frans
Published: March 2017

This paper experimentally investigates how monetary incentives and emotions influence behavior in a two-player power-to-take game (PTTG). In this game, one player can claim any part of the other's endowment (take rate), and the second player can respond by destroying any part of his or her own endowment. The experiment is run in China. We further compare our findings with the behavior of two European subject pools. Our results give new insights regarding emotion regulation. Even though stake size does not appear to matter for take rates and destruction rates, it does matter for the reaction function of the responder regarding the take rate. When stakes are high, there is less destruction for low and intermediate take rates, and more destruction for high take rates, compared to relatively low stakes. Under low incentives, ‘hot’ anger-type emotions are important for destruction, while ‘cool’ contempt becomes prominent under high monetary incentives. These results suggest emotion regulation in the high-stake condition. Moreover, emotions are found to fully mediate the impact of the take rate on destruction when stakes are low, whereas they only partially do so if stakes are high. Comparing the low-stakes data for China with existing European data, we find similarities in behavior, emotions and emotion intensities, as well as the full mediation of the take rate by emotions. We find some differences related to the type of emotions that are important for destruction. Whereas anger and joy are important in both, in addition, irritation and fear play a role in China, while this holds for contempt in the EU.
Perennial Lakes as an Environmental Control on Theropod Movement in the Jurassic of the Hartford Basin
Authors: Getty Patrick , Aucoin Christopher , Fox Nathaniel , Judge Aaron , Hardy Laurel , Bush Andrew
Published: March 2017

Eubrontes giganteus is a common ichnospecies of large dinosaur track in the Early Jurassic rocks of the Hartford and Deerfield basins in Connecticut and Massachusetts, USA. It has been proposed that the trackmaker was gregarious based on parallel trackways at a site in Massachusetts known as Dinosaur Footprint Reservation (DFR). The gregariousness hypothesis is not without its problems, however, since parallelism can be caused by barriers that direct animal travel. We tested the gregariousness hypothesis by examining the orientations of trackways at five sites representing permanent and ephemeral lacustrine environments. Parallelism is only prominent in permanent lacustrine rocks at DFR, where trackways show a bimodal orientation distribution that approximates the paleoshoreline. By contrast, parallel trackways are uncommon in ephemeral lacustrine facies, even at sites with large numbers of trackways, and those that do occur exhibit differences in morphology, suggesting that they were made at different times. Overall, the evidence presented herein suggests that parallelism seen in Hartford Basin Eubrontes giganteus is better explained as a response to the lake acting as a physical barrier rather than to gregariousness. Consequently, these parallel trackways should not be used as evidence to support the hypothesis that the trackmaker was a basal sauropodomorph unless other evidence can substantiate the gregariousness hypothesis.
Mobile Phonocardiogram Diagnosis in Newborns Using Support Vector Machine
Authors: Amiri Amir , Abtahi Mohammadreza , Constant Nick , Mankodiya Kunal
Published: March 2017

Phonocardiogram (PCG) monitoring on newborns is one of the most important and challenging tasks in the heart assessment in the early ages of life. In this paper, we present a novel approach for cardiac monitoring applied in PCG data. This basic system coupled with denoising, segmentation, cardiac cycle selection and classification of heart sound can be used widely for a large number of the data. This paper describes the problems and additional advantages of the PCG method including the possibility of recording heart sound at home, removing unwanted noises and data reduction on a mobile device, and an intelligent system to diagnose heart diseases on the cloud server. A wide range of physiological features from various analysis domains, including modeling, time/frequency domain analysis, an algorithm, etc., is proposed in order to extract features which will be considered as inputs for the classifier. In order to record the PCG data set from multiple subjects over one year, an electronic stethoscope was used for collecting data that was connected to a mobile device. In this study, we used different types of classifiers in order to distinguish between healthy and pathological heart sounds, and a comparison on the performances revealed that support vector machine (SVM) provides 92.2% accuracy and AUC = 0.98 in a time of 1.14 seconds for training, on a dataset of 116 samples.
Brain-Derived Neurotrophic Factor Loaded PS80 PBCA Nanocarrier for In Vitro Neural Differentiation of Mouse Induced Pluripotent Stem Cells
Authors: Chung Chiu-Yen , Lin Martin , Lee I-Neng , Lee Tsong-Hai , Lee Ming-Hsueh , Yang Jen-Tsung
Published: March 2017

Brain derived neurotrophic factor (BDNF) can induce neural differentiation in stem cells and has the potential for repair of the nervous system. In this study, a polysorbate 80-coated polybutylcyanoacrylate nanocarrier (PS80 PBCA NC) was constructed to deliver plasmid DNAs (pDNAs) containing BDNF gene attached to a hypoxia-responsive element (HRE-cmvBDNF). The hypoxia-sensing mechanism of BDNF expression and inductiveness of the nano-formulation on mouse induced pluripotent stem cells (iPSCs) to differentiate into neurons following hypoxia was tested in vitro with immunofluorescent staining and Western blotting. The HRE-cmvBDNF appeared to adsorb onto the surface of PS80 PBCA NC, with a resultant mean diameter of 92.6 ± 1.0 nm and zeta potential of −14.1 ± 1.1 mV. HIF-1α level in iPSCs was significantly higher in hypoxia, which resulted in a 51% greater BDNF expression when transfected with PS80 PBCA NC/HRE-cmvBDNF than those without hypoxia. TrkB and phospho-Akt were also elevated which correlated with neural differentiation. The findings suggest that PS80 PBCA NC too can be endocytosed to serve as an efficient vector for genes coupled to the HRE in hypoxia-sensitive cells, and activation of the PI3/Akt pathway in iPSCs by BDNF is capable of neural lineage specification.
Endoplasmic Reticulum Stress and Unfolded Protein Response in Cartilage Pathophysiology; Contributing Factors to Apoptosis and Osteoarthritis
Authors: Hughes Alexandria , Oxford Alexandra , Tawara Ken , Jorcyk Cheryl , Oxford Julia
Published: March 2017

Chondrocytes of the growth plate undergo apoptosis during the process of endochondral ossification, as well as during the progression of osteoarthritis. Although the regulation of this process is not completely understood, alterations in the precisely orchestrated programmed cell death during development can have catastrophic results, as exemplified by several chondrodystrophies which are frequently accompanied by early onset osteoarthritis. Understanding the mechanisms that underlie chondrocyte apoptosis during endochondral ossification in the growth plate has the potential to impact the development of therapeutic applications for chondrodystrophies and associated early onset osteoarthritis. In recent years, several chondrodysplasias and collagenopathies have been recognized as protein-folding diseases that lead to endoplasmic reticulum stress, endoplasmic reticulum associated degradation, and the unfolded protein response. Under conditions of prolonged endoplasmic reticulum stress in which the protein folding load outweighs the folding capacity of the endoplasmic reticulum, cellular dysfunction and death often occur. However, unfolded protein response (UPR) signaling is also required for the normal maturation of chondrocytes and osteoblasts. Understanding how UPR signaling may contribute to cartilage pathophysiology is an essential step toward therapeutic modulation of skeletal disorders that lead to osteoarthritis.
Extracellular Vesicles Deliver Host and Virus RNA and Regulate Innate Immune Response
Authors: Kouwaki Takahisa , Okamoto Masaaki , Tsukamoto Hirotake , Fukushima Yoshimi , Oshiumi Hiroyuki
Published: March 2017

The innate immune system plays a crucial role in controlling viral infection. Pattern recognition receptors (PRRs), such as Toll-like receptors and RIG-I-like receptors, sense viral components called pathogen-associated molecular patterns (PAMPs) and trigger signals to induce innate immune responses. Extracellular vesicles (EVs), including exosomes and microvesicles, deliver functional RNA and mediate intercellular communications. Recent studies have revealed that EVs released from virus-infected cells deliver viral RNA to dendritic cells and macrophages, thereby activating PRRs in recipient cells, which results in the expression of type I interferon and pro-inflammatory cytokines. On the other hand, EVs transfer not only viral RNA but also host microRNAs to recipient cells. Recently, infection of hepatocytes with hepatitis B virus (HBV) was shown to affect microRNA levels in EVs released from virus-infected cells, leading to attenuation of host innate immune response. This suggests that the virus utilizes the EVs and host microRNAs to counteract the antiviral innate immune responses. In this review, we summarize recent findings related to the role of EVs in antiviral innate immune responses.
Automated Detection of Liver Histopathological Findings Based on Biopsy Image Processing
Authors: Tsiplakidou Maria , Tsipouras Markos , Giannakeas Nikolaos , Tzallas Alexandros , Manousou Pinelopi
Published: March 2017

Hepatic steatosis is the accumulation of fat in the hepatic cells and the liver. Triglycerides and other kinds of molecules are included in the lipids. When there is some defect in the process, hepatic steatosis arise, during which the free fatty acids are taken by the liver and exuded as lipoproteins. Alcohol is the main cause of steatosis when excessive amounts are consumed for a long period of time. In many cases, steatosis can lead to inflammation that is mentioned as steatohepatitis or non-alcoholic steatohepatitis (NASH), which can later lead to fibrosis and finally cirrhosis. For automated detection and quantification of hepatic steatosis, a novel two-stage methodology is developed in this study. Initially, the image is processed in order to become more suitable for the detection of fat regions and steatosis quantification. In the second stage, initial candidate image regions are detected, and then they are either validated or discarded based on a series of criteria. The methodology is based on liver biopsy image analysis, and has been tested using 40 liver biopsy images obtained from patients who suffer from hepatitis C. The obtained results indicate that the proposed methodology can accurately assess liver steatosis.
The History of Clotting Factor Concentrates Pharmacokinetics
Authors: Morfini Massimo
Published: March 2017

Clotting factor concentrates (CFCs) underwent tremendous modifications during the last forty years. Plasma-derived concentrates made the replacement therapy feasible not only in the hospital but also at patients’ home by on-demand or prophylactic regimen. Virucidal methods, implemented soon after hepatitis and AIDS outbreak, and purification by Mabs made the plasma-derived concentrates safer and purer. CFCs were considered equivalent to the other drugs and general rules and methods of pharmacokinetics (PK) were applied to their study. After the first attempts by graphical methods and calculation of In Vivo Recovery, compartment and non-compartment methods were applied also to the study of PK of CFCs. The bioequivalence of the new concentrates produced by means of recombinant DNA biotechnology was evaluated in head-to-head PK studies. Since the beginning, the large inter-patient variability of dose/response of replacement therapy was realized. PK allowed tailoring haemophilia therapy and PK driven prophylaxis resulted more cost effective. Unfortunately, the need of several blood samples and logistic difficulties made the PK studies very demanding. Recently, population PK (PopPK) has been applied to the prediction of CFCs dosing by Bayesian methodology. By PopPK also sparse data may allow evaluating the appropriateness of replacement therapy.
Application of State of the Art Modeling Techniques to Predict Flooding and Waves for a Coastal Area within a Protected Bay
Authors: Spaulding Malcolm L. , Grilli Annette , Damon Chris , Fugate Grover , Isaji Tatsu , Schambach Lauren
Published: March 2017

Flood Insurance Rate Maps (FIRMs) are developed by the Federal Emergency Management Agency (FEMA) to provide guidance in establishing the risk to structures and infrastructure from storm surge sand associated waves in the coastal zone. The maps are used by state agencies and municipalities to help guide coastal planning and establish the minimum elevation and construction standards for new or substantially improved structures. A summary of the methods used and a comparison with the results of 2013 FIRM mapping are presented for Warwick, Rhode Island (RI), a coastal community located within Narragansett Bay. Because of its location, Warwick is protected from significant coastal erosion and wave attacks, but is subject to surge amplification. Concerns surrounding the FEMA methods used in the 2013 FIRM analysis are put in context with the National Research Council’s (NRC) 2009 review of the FEMA coastal mapping program. New mapping is then performed using state of the art, fully coupled surge and wave modeling, and data analysis methods, to address the NRC concerns. The new maps and methodologies are in compliance with FEMA regulations and guidelines. This new approach makes extensive use of the numerical modeling results from the recent US Army Corp of Engineers, North Atlantic Coast Comprehensive Study (NACCS, 2015). Revised flooding maps are presented and compared to the 2013 FIRM maps, to provide insight into the differences. The new maps highlight the importance of developing better estimates of surge dynamics and the advancement in nearshore mapping of waves in flood inundated areas by the use of state of the art, two-dimensional, wave transformation models.
VO2 Thermochromic Films on Quartz Glass Substrate Grown by RF-Plasma-Assisted Oxide Molecular Beam Epitaxy
Authors: Zhang Dong , Sun Hong-Jun , Wang Min-Huan , Miao Li-Hua , Liu Hong-Zhu , Zhang Yu-Zhi , Bian Ji-Ming
Published: March 2017

Vanadium dioxide (VO2) thermochromic thin films with various thicknesses were grown on quartz glass substrates by radio frequency (RF)-plasma assisted oxide molecular beam epitaxy (O-MBE). The crystal structure, morphology and chemical stoichiometry were investigated systemically by X-ray diffraction (XRD), atomic force microscopy (AFM), Raman spectroscopy and X-ray photoelectron spectroscopy (XPS) analyses. An excellent reversible metal-to-insulator transition (MIT) characteristics accompanied by an abrupt change in both electrical resistivity and optical infrared (IR) transmittance was observed from the optimized sample. Remarkably, the transition temperature (TMIT) deduced from the resistivity-temperature curve was reasonably consistent with that obtained from the temperature-dependent IR transmittance. Based on Raman measurement and XPS analyses, the observations were interpreted in terms of residual stresses and chemical stoichiometry. This achievement will be of great benefit for practical application of VO2-based smart windows.
Metabolic Disorder in Chronic Obstructive Pulmonary Disease (COPD) Patients: Towards a Personalized Approach Using Marine Drug Derivatives
Authors: Lamonaca Palma , Prinzi Giulia , Kisialiou Aliaksei , Cardaci Vittorio , Fini Massimo , Russo Patrizia
Published: March 2017

Metabolic disorder has been frequently observed in chronic obstructive pulmonary disease (COPD) patients. However, the exact correlation between obesity, which is a complex metabolic disorder, and COPD remains controversial. The current study summarizes a variety of drugs from marine sources that have anti-obesity effects and proposed potential mechanisms by which lung function can be modulated with the anti-obesity activity. Considering the similar mechanism, such as inflammation, shared between obesity and COPD, the study suggests that marine derivatives that act on the adipose tissues to reduce inflammation may provide beneficial therapeutic effects in COPD subjects with high body mass index (BMI).
Theoretical and Experimental Study on Vibration Propagation in PMMA Components in Ultrasonic Bonding Process
Authors: Sun Yibo , Wang Feng , Yang Xinhua
Published: March 2017

Ultrasonic bonding has an increasing application in the micro assembly of polymeric micro-electro mechanical systems (MEMS) with high requirements for fusion precision. In the ultrasonic bonding process, the propagation of ultrasonic vibration in polymer components is related to the interfacial fusion, which can be used as a monitoring parameter to control ultrasonic energy. To study the vibration propagation in viscoelastic polymer components, finite element analysis on the bonding of poly methyl methacrylate (PMMA) micro connector to substrate for microfluidic system is carried out. Curves of propagated vibration amplitude corresponding to interfacial temperatures are obtained. The ultrasonic vibration propagated in PMMA components are measured through experiments. The theoretical and experimental results are contrasted to analyze the change mechanism of vibration propagation related to temperature. Based on the ultrasonic bonding process controlled by the feedback of vibration propagation, interfacial fusions at different vibration propagation states are obtained through experiments. Interfacial fusion behavior is contrasted to the propagated vibration amplitude in theoretical and experimental studies. The relation between vibration propagation and fusion degree is established with the proper parameter range for the obtained high quality bonding.
Therapeutic Potentials of Microalgae in the Treatment of Alzheimer’s Disease
Authors: Olasehinde Tosin , Olaniran Ademola , Okoh Anthony
Published: March 2017

Current research is geared towards the discovery of new compounds with strong neuroprotective potential and few or no side effects compared to synthetic drugs. This review focuses on the potentials of extracts and biologically active compounds derived from microalgal biomass for the treatment and management of Alzheimer’s disease (AD). Microalgal research has gained much attention recently due to its contribution to the production of renewable fuels and the ability of alga cells to produce several secondary metabolites such as carotenoids, polyphenols, sterols, polyunsaturated fatty acids and polysaccharides. These compounds exhibit several pharmacological activities and possess neuroprotective potential. The pathogenesis of Alzheimer’s disease (AD) involves complex mechanisms that are associated with oxidative stress, cholinergic dysfunction, neuronal damage, protein misfolding and aggregation. The antioxidant, anticholinesterase activities as well as the inhibitory effects of some bioactive compounds from microalgae extracts on β-amyloid aggregation and neuronal death are discussed extensively. Phytochemical compounds from microalgae are used as pharmaceuticals, nutraceuticals and food supplements, and may possess neuroprotective potentials that are relevant to the management and/or treatment of AD.
In Vitro Antioxidant Activity and In Vivo Anti-Fatigue Effect of Sea Horse (Hippocampus) Peptides
Authors: Guo Zebin , Lin Duanquan , Guo Juanjuan , Zhang Yi , Zheng Baodong
Published: March 2017

This study investigated changes the in vitro antioxidant activity of Hippocampus polypeptides during enzymatic hydrolysis, including the effects of enzyme species, enzyme concentration, material–liquid ratio, hydrolysis time, pH, and temperature of the reaction system. Its in vivo anti-fatigue activity was also studied. Hippocampus peptide prepared by papain digestion exhibited the highest 1,1-diphenyl-2-picryl-hydrazyl free radical scavenging rate (71.89% ± 1.50%) and strong hydroxyl radical scavenging rate (75.53% ± 0.98%), compared to those prepared by five other commonly used enzymes (i.e., trypsin, neutral protease, compound protease, flavorzyme, and alkaline protease). Additionally, maximum antioxidant activity of Hippocampus polypeptide prepared by papain digestion was reached after hydrolysis for 40 min at pH 6.0 and 60 °C of the reaction system by using 2000 U/g enzyme and a material–liquid ratio of 1:15. Moreover, compared with the control group, Hippocampus peptide prolonged the swimming time by 33%–40%, stabilized the blood glucose concentration, increased liver glycogen levels, and decreased blood lactate levels and blood urea nitrogen levels in mice (p < 0.01). In conclusion, these results indicated that Hippocampus polypeptide prepared by papain digestion under optimal conditions exhibited high degrees of antioxidant and anti-fatigue activity.
Effects of Momordica charantia (Bitter Melon) on Ischemic Diabetic Myocardium
Authors: Czompa Attila , Gyongyosi Alexandra , Szoke Kitti , Bak Istvan , Csepanyi Evelin , Haines David , Tosaki Arpad , Lekli Istvan
Published: March 2017

Objective: A rat model is here used to test a hypothesis that Momordica charantia (Bitter melon (BM)) extract favorably alters processes in cardiovascular tissue and is systemically relevant to the pathophysiology of type 2 diabetes (T2DM) and related cardiovascular disease. Methods: Male Lean and Zucker Obese (ZO) rats were gavage-treated for six weeks with 400 mg/kg body weight bitter melon (BM) extract suspended in mucin–water vehicle, or with vehicle (Control). Animals were segregated into four treatment groups, 10 animals in each group, according to strain (Lean or ZO) and treatment (Control or BM). Following six-week treatment periods, peripheral blood was collected from selected animals, followed by sacrifice, thoracotomy and mounting of isolated working heart setup. Results: Body mass of both Lean and ZO rats was unaffected by treatment, likewise, peripheral blood fasting glucose levels showed no significant treatment-related effects. However, some BM treatment-related improvement was noted in postischemic cardiac functions when Lean, BM-treated animals were compared to vehicle treated Lean control rats. Treatment of Lean, but not ZO, rats significantly reduced the magnitude of infarcted zone in isolated hearts subjected to 30 min of ischemia followed by 2 h of working mode reperfusion. Immunohistochemical demonstration of caspase-3 expression by isolated heart tissues subjected to 30 min of ischemia followed by 2 h of reperfusion, revealed significant correlation between BM treatment and reduced expression of this enzyme in hearts obtained from both Lean and ZO animals. The hierarchy and order of caspase-3 expression from highest to lowest was as follows: ZO rats receiving vehicle > ZO rats receiving BM extract > Lean rats treated receiving vehicle > Lean rats administered BM extract. Outcomes of analyses of peripheral blood content of cardiac-related analytics: with particular relevance to clinical application was a significant elevation in blood of ZO and ZO BM-treated, versus Lean rats of total cholesterol (high density lipoprotein HDL-c + low density lipoprotein LDL-c), with an inferred increase in HDL-c/LDL-c ratio—an outcome associated with decreased risk of atherosclerotic disease. Conclusions: BM extract failed to positively affect T2DM- and cardiovascular-related outcomes at a level suggesting use as a standalone treatment. Nevertheless, the encouraging effects of BM in enhancement of cardiac function, suppression of post-ischemic/reperfused infarct size extent and capacity to modulate serum cholesterol, will likely make it useful as an adjuvant therapy for the management of T2DM and related cardiovascular diseases.
New Chiral Ebselen Analogues with Antioxidant and Cytotoxic Potential
Authors: Pacuła Agata J. , Kaczor Katarzyna B. , Antosiewicz Jędrzej , Janecka Anna , Długosz Angelika , Janecki Tomasz , Wojtczak Andrzej , Ścianowski Jacek
Published: March 2017

New chiral camphane-derived benzisoselenazol-3(2H)-ones and corresponding diselenides have been synthetized using a convenient one-pot procedure. Se-N bond was efficiently converted to an Se-Se bond, which could also be easily re-oxidized to the initial benzisoselenazolone moiety. The antioxidant activity of camphor derivatives was evaluated and compared to the reactivity of a series of N-amino acid benzisoselenazol-3(2H)-ones obtained by a modified procedure involving the improved synthesis and isolation of the diseleno bis(dibenzoic) acid. The most efficient peroxide scavengers, N-bornyl and N-leucine methyl ester benzisoselenazol-3(2H)-ones, were further evaluated as cytotoxic agents on four cancer cell lines (MCF-7, HEP G2, HL 6, and DU 145) and normal cell line PNT1A. The highest antiproliferative potential was evaluated for two compounds bearing a 3-methylbutyl carbon chain, N-leucine methyl ester and N-3-methylbutyl benzisoselenazol-3(2H)-ones.
Magnetic Hybrid Nanosorbents for the Uptake of Paraquat from Water
Authors: Fernandes Tiago , Soares Sofia , Trindade Tito , Daniel-da-Silva Ana
Published: March 2017

Although paraquat has been banned in European countries, this herbicide is still used all over the world, thanks to its low-cost, high-efficiency, and fast action. Because paraquat is highly toxic to humans and animals, there is interest in mitigating the consequences of its use, namely by implementing removal procedures capable of curbing its environmental and health risks. This research describes new magnetic nanosorbents composed of magnetite cores functionalized with bio-hybrid siliceous shells, that can be used to uptake paraquat from water using magnetically-assisted procedures. The biopolymers κ-carrageenan and starch were introduced into the siliceous shells, resulting in two hybrid materials, Fe3O4@SiO2/SiCRG and Fe3O4@SiO2/SiStarch, respectively, that exhibit a distinct surface chemistry. The Fe3O4@SiO2/SiCRG biosorbents displayed a superior paraquat removal performance, with a good fitting to the Langmuir and Toth isotherm models. The maximum adsorption capacity of paraquat for Fe3O4@SiO2/SiCRG biosorbents was 257 mg·g−1, which places this sorbent among the best systems for the removal of this herbicide from water. The interesting performance of the κ-carrageenan hybrid, along with its magnetic properties and good regeneration capacity, presents a very efficient way for the remediation of water contaminated with paraquat.
Optoelectronic Properties of Van Der Waals Hybrid Structures: Fullerenes on Graphene Nanoribbons
Authors: Correa Julián , Orellana Pedro , Pacheco Mónica
Published: March 2017

The search for new optical materials capable of absorbing light in the frequency range from visible to near infrared is of great importance for applications in optoelectronic devices. In this paper, we report a theoretical study of the electronic and optical properties of hybrid structures composed of fullerenes adsorbed on graphene and on graphene nanoribbons. The calculations are performed in the framework of the density functional theory including the van der Waals dispersive interactions. We found that the adsorption of the C 60 fullerenes on a graphene layer does not modify its low energy states, but it has strong consequences for its optical spectrum, introducing new absorption peaks in the visible energy region. The optical absorption of fullerenes and graphene nanoribbon composites shows a strong dependence on photon polarization and geometrical characteristics of the hybrid systems, covering a broad range of energies. We show that an external electric field across the nanoribbon edges can be used to tune different optical transitions coming from nanoribbon–fullerene hybridized states, which yields a very rich electro-absorption spectrum for longitudinally polarized photons. We have carried out a qualitative analysis on the potential of these hybrids as possible donor-acceptor systems in photovoltaic cells.
Melanin-Associated Synthesis of SERS-Active Nanostructures and the Application for Monitoring of Intracellular Melanogenesis
Authors: Dong Haixin , Liu Zhiming , Zhong Huiqing , Yang Hui , Zhou Yan , Hou Yuqing , Long Jia , Lin Jin , Guo Zhouyi
Published: March 2017

Melanin plays an indispensable role in the human body. It serves as a biological reducer for the green synthesis of precious metal nanoparticles. Melanin–Ag nanocomposites were successfully produced which exhibited very strong surface-enhanced Raman scattering (SERS) effect because of the reducibility property of melanin. A melanin–Ag composite structure was synthesized in situ in melanin cells, and SERS technique was performed for the rapid imaging and quantitative assay of intracellular melanin. This imaging technique was also used to successfully trace the formation and secretion of intracellular melanin after stimulation with melanin-stimulating hormones. Based on the self-reducing property of melanin, the proposed SERS imaging method can provide potentially powerful analytical detection tools to study the biological functions of melanin and to prevent and cure melanin-related diseases.