bluuebunny/crossref_metadata_2025 huggingface dataset:
Sociodemographic Disparities in the Treatment of Hypothyroidism: NHANES 2007–2012
Authors: Ettleson Matthew D , Bianco Antonio C , Zhu Mengqi , Laiteerapong Neda
Published: March 2021

Purpose

Both undertreatment and overtreatment of hypothyroidism with thyroid hormone are associated with adverse clinical outcomes. Disparities in the treatment of hypothyroidism may lead to a higher risk of adverse outcomes for certain sociodemographic groups. Our objectives were to identify sociodemographic disparities between those with treated and untreated hypothyroidism, and between those who were adequately and inadequately treated.

Methods

This is a cross-sectional study of a representative sample of US adults aged 20 years and older with hypothyroidism (n = 698). The main measures were age, gender, race/ethnicity, education, income, and health care access differences among those with treated and untreated hypothyroidism.

Results

Of those with hypothyroidism, women were more likely than men to be taking thyroid hormone (odds ratio [OR] 2.66 [95% confidence interval (CI) 1.42–4.99]), as were older participants (45–69 years old vs 20–44 years old: OR 7.25 [95% CI 4.15–12.67]; 70 years of age and older: OR 11.00 [95% CI 5.30–22.79]). Health care access was strongly associated with thyroid hormone use (OR 14.32, 95% CI 3.63–56.58). Hispanic race/ethnicity was associated with inadequate treatment compared with non-Hispanic whites (OR 2.42, 95% CI: 1.14–5.14).

Main Conclusions

Male gender, younger age, and lack of health care access were associated with untreated hypothyroidism, and Hispanic race was associated with inadequate treatment of hypothyroidism. Clinicians should be aware of these sociodemographic disparities in the hypothyroid population and consider strategies to improve treatment of hypothyroidism in men, younger adults, Hispanics, and those without routine health care access.
Influence of Different Measurements on the Ability of P-SAP and DES-OSA Scores to Detect Severe Obstructive Sleep Apnea
Authors: Deflandre Eric P. , Cester Luca , Degey Stephanie V.
Published: March 2021

BACKGROUND:

Severe obstructive sleep apnea (sOSA) represents a risk factor of postoperative complications. Perioperative sleep apnea prediction (P-SAP) and DES-obstructive sleep apnea (DES-OSA) (DES being the acronym for 2 of the participating investigators and OSA for obstructive sleep apnea) scores were validated in the detection of such patients. They include the measurement of neck circumference (NC) and distance between thyroid and chin (DTC). The aim of this study was to evaluate the influence of the measurement method of NC and DTC on the ability of the 2 scores to detect sOSA.

METHODS:

A total of 371 preoperative patients were enrolled. For each of them, 6 combinations of P-SAP and DES-OSA scores were evaluated. We compared the results of the 6 combinations with the data extracted from the polysomnography (PSG) if available. The ability of the score to detect sOSA patients was evaluated using sensitivity (Se), specificity (Sp), Youden index (YI), area under receiver operating characteristic curve (AUROC), the Probit model, and the Kappa coefficient of Cohen. A P < .05 was considered as significant, a Bonferroni correction was applied if needed.

RESULTS:

Three hundred and seventy-one patients had a PSG. The Se and the Sp of the DES-OSA score, and the Sp of the P-SAP score, in their ability to detect severe OSA patients, were influenced by the measurement method of the DTC and of the NC. Nevertheless, the AUROC, the Youden index, the Probit model, and the Kappa coefficient of Cohen are not influenced by the variability of measurement.

CONCLUSIONS:

This study highlights that the measurement method of NC and DTC can influence the results of the 2 scores. We conclude that a strict protocol for the measurement of NC and DTC should be applied (DTC measurement should be performed on a patient with a head in neutral position and the NC measurement should be performed at the cricoid level).
An Inner Voice Liberated
Authors: Marnin-Distelfeld Shahar
Published: March 2021

This article examines the works of Israeli woman artist Lilian Weisberger, who creates girlhood images that look naive at first glance but are nonetheless multilayered and radical. This examination of Weisberger’s girlhood images is done here for the first time. Applying the bricolage methodology, the investigation of her artwork is based on a visual analysis, in-depth interviews with Weisberger, and feminist theories relevant to girlhood studies combined with several concepts from the field of psychology. Three series are discussed: the dark-gloomy images, bodiless images, and the group of super-girls and defiant ones. These images represent two substantial parts of the girl’s soul—vulnerability versus intensity—while metaphorically materializing a feminist call for authenticity and wholeness of the girl, and eventually the woman. Weisberger’s art embodies a quest for liberating an inner voice through creation.
Styling Strength
Authors: Pahwa Sonali
Published: March 2021

In 2014, amid anti-Islamist sentiment in Egypt, the athlete Manal Rostom founded a Facebook group to support hijabis. Intended as a space of internal discussion and solidarity, it grew into one of Facebook’s largest groups worldwide. Analyzing posts on this forum and its offshoot Instagram page, this article examines digital repertoires of Muslim women’s self-styling as both pious and liberal. While the women-only Facebook group reproduced existing religious norms in contemporary language, the Instagram platform generated self-modulated performances of fashion and fitness, blurring lines between liberal and Islamic feminism. The article analyzes the use of digital platforms to construct both a hijabi support group and an influencer platform, arguing that this two-pronged project signified hijab as an ethical and performance practice. As a symbol of self-discipline that moved between the worlds of style and sport, hijab in this digital forum supplemented representations of religious consumerism with competitive performances of strength.
Unfair Advantage Discourse in USA Powerlifting
Authors: Jones CJ
Published: March 2021

This essay follows the social life of testosterone during a presentation at a USA Powerlifting national governing board meeting. While feminist and queer sports analyses focus on the implication of hormone levels for intersex athletes, much less scholarship analyzes how the hang-up on testosterone itself—whether endogenously produced or pharmaceutically regulated—unjustly targets transgender athletes. Paying attention to how testosterone delineates the boundary between “fair” and “unfair advantage” that consolidates antitrans contours of “female athlete,” this essay seeks to model a closer collaboration between transgender studies and feminist sports studies to forge what the author calls transfeminist sports studies.
Early Modern Transgender Fairies
Authors: Horbury Ezra
Published: March 2021

The early modern fairy is a long ignored transgender figure. This article presents a transhistoricist analysis of how a range of “transgender” concepts manifest in the early modern literary imagination—instabilities, transformations, ambiguities, or indeterminacies in sex and gender—through the representation of fairies and the supernatural. It focuses on Ariel in Shakespeare's Tempest, Duessa in Spenser's Faerie Queene, and Jocastus in Randolph's Amyntas. Breaking from the threatening fairies of the medieval tradition, early modern writers reshaped how fairies were conceptualized in popular imagination, which inform our ideas of the supernatural and gender instability to this day. While transgender approaches to the medieval period have recently come to prominence, transgender approaches to the early modern remain marginal. This article seeks to establish what early modern fairies offer transgender theory and what transgender theory can offer early modern historicism. Through transgender readings of fairies and supernatural figures, this article demonstrates how such figures provided a space in which early modern culture could fantastically conceptualize transgender concepts and identities.
Futuring Trans* in Pakistan
Authors: Kasmani Omar
Published: March 2021

Futuring trans* is a deliberation on the emergence of transgender alongside khwajasara, both newer terms in Pakistan that acquire distinctly temporal agencies insofar as these untether individuals from difficult histories and offer new affective means for future making. Not the same as the identity transgender, trans* in Pakistan, this article proposes, is a baggy and emergent ground where not only locally specific meanings around gender variability are being pushed out and projected anew but where its historical, trans-local, cross-scalar, and open-ended working out is mappable. To outline its futural shapes, this text closely traces a set of affective, representational, and practical strategies as part of an unfinished, contested, and dynamic process of encounters across a variety of allies and actors: individuals, institutions, collectives, spaces, and networks. It illustrates, on the one hand, how trans* in Pakistan kicks off a capacious contact zone, triggers cross-sectional encounters, and generates momentum with implications, which impact but also exceed local conditions. On the other hand, it observes how its horizons might be curtailed by conditions and concerns that privilege some ways of gender nonconforming over certain others.
Validating accelerometry-derived proxies of energy expenditure using the doubly labelled water method in the smallest penguin species
Authors: Sutton G. J. , Botha J. A. , Speakman J. R. , Arnould J. P. Y.
Published: March 2021

Understanding energy use is central to understanding an animal's physiological and behavioural ecology. However, directly measuring energy expenditure in free-ranging animals is inherently difficult. The doubly labelled water (DLW) method is widely used to investigate energy expenditure in a range of taxa. Although reliable, DLW data collection and analysis is both financially costly and time consuming. Dynamic body acceleration (e.g. VeDBA) calculated from animal-borne accelerometers has been used to determine behavioural patterns, and is increasingly being used as a proxy for energy expenditure. Still its performance as a proxy for energy expenditure in free-ranging animals is not well established and requires validation against established methods. In the present study, the relationship between VeDBA and the at-sea metabolic rate calculated from DLW was investigated in little penguins (Eudyptula minor) using three approaches. Both in a simple correlation and activity-specific approaches were shown to be good predictors of at-sea metabolic rate. The third approach using activity-specific energy expenditure values obtained from literature did not accurately calculate the energy expended by individuals. However, all three approaches were significantly strengthened by the addition of mean horizontal travel speed. These results provide validation for the use of accelerometry as a proxy for energy expenditure and show how energy expenditure may be influenced by both individual behaviour and environmental conditions.
Zebrafish dazl regulates cystogenesis and germline stem cell specification during the primordial germ cell to germline stem cell transition
Authors: Bertho Sylvain , Clapp Mara , Banisch Torsten U. , Bandemer Jan , Raz Erez , Marlow Florence L.
Published: March 2021

Fertility and gamete reserves are maintained by asymmetric divisions of the germline stem cells to produce new stem cells or daughters that differentiate as gametes. Before entering meiosis, differentiating germ cells (GCs) of sexual animals typically undergo cystogenesis. This evolutionarily conserved process involves synchronous and incomplete mitotic divisions of a GC daughter (cystoblast) to generate sister cells connected by intercellular bridges that facilitate the exchange of materials to support rapid expansion of the gamete progenitor population. Here, we investigated cystogenesis in zebrafish and found that early GCs are connected by ring canals, and show that Deleted in azoospermia-like (Dazl), a conserved vertebrate RNA-binding protein (Rbp), is a regulator of this process. Analysis of dazl mutants revealed the essential role of Dazl in regulating incomplete cytokinesis, germline cyst formation and germline stem cell specification before the meiotic transition. Accordingly, dazl mutant GCs form defective ring canals, and ultimately remain as individual cells that fail to differentiate as meiocytes. In addition to promoting cystoblast divisions and meiotic entry, dazl is required for germline stem cell establishment and fertility.
Dynamics of hunchback translation in real-time and at single-mRNA resolution in the Drosophila embryo
Authors: Vinter Daisy J. , Hoppe Caroline , Minchington Thomas G. , Sutcliffe Catherine , Ashe Hilary L.
Published: March 2021

The Hunchback (Hb) transcription factor is crucial for anterior-posterior patterning of the Drosophila embryo. The maternal hb mRNA acts as a paradigm for translational regulation due to its repression in the posterior of the embryo. However, little is known about the translatability of zygotically transcribed hb mRNAs. Here, we adapt the SunTag system, developed for imaging translation at single-mRNA resolution in tissue culture cells, to the Drosophila embryo to study the translation dynamics of zygotic hb mRNAs. Using single-molecule imaging in fixed and live embryos, we provide evidence for translational repression of zygotic SunTag-hb mRNAs. Whereas the proportion of SunTag-hb mRNAs translated is initially uniform, translation declines from the anterior over time until it becomes restricted to a posterior band in the expression domain. We discuss how regulated hb mRNA translation may help establish the sharp Hb expression boundary, which is a model for precision and noise during developmental patterning. Overall, our data show how use of the SunTag method on fixed and live embryos is a powerful combination for elucidating spatiotemporal regulation of mRNA translation in Drosophila.
Myosin-X is dispensable for spindle morphogenesis and positioning in the mouse oocyte
Authors: Crozet Flora , Da Silva Christelle , Verlhac Marie-Hélène , Terret Marie-Emilie
Published: March 2021

Off-center spindle positioning in mammalian oocytes enables asymmetric divisions in size, which are important for subsequent embryogenesis. The migration of the meiosis I spindle from the oocyte center to its cortex is mediated by F-actin. Specifically, an F-actin cage surrounds the microtubule spindle and applies forces to it. To better understand how F-actin transmits forces to the spindle, we studied a potential direct link between F-actin and microtubules. For this, we tested the implication of myosin-X, a known F-actin and microtubule binder involved in spindle morphogenesis and/or positioning in somatic cells, amphibian oocytes and embryos. Using a mouse strain conditionally invalidated for myosin-X in oocytes and by live-cell imaging, we show that myosin-X is not localized on the spindle, and is dispensable for spindle and F-actin assembly. It is not required for force transmission as spindle migration and chromosome alignment occur normally. More broadly, myosin-X is dispensable for oocyte developmental potential and female fertility. We therefore exclude a role for myosin-X in transmitting F-actin-mediated forces to the spindle, opening new perspectives regarding this mechanism in mouse oocytes, which differ from most mitotic cells.
Selective disruption of trigeminal sensory neurogenesis and differentiation in a mouse model of 22q11.2 deletion syndrome
Authors: Karpinski Beverly A. , Maynard Thomas M. , Bryan Corey A. , Yitsege Gelila , Horvath Anelia , Lee Norman H. , Moody Sally A. , LaMantia Anthony-Samuel
Published: March 2021

22q11.2 Deletion Syndrome (22q11DS) is a neurodevelopmental disorder associated with cranial nerve anomalies and disordered oropharyngeal function, including pediatric dysphagia. Using the LgDel 22q11DS mouse model, we investigated whether sensory neuron differentiation in the trigeminal ganglion (CNgV), which is essential for normal orofacial function, is disrupted. We did not detect changes in cranial placode cell translocation or neural crest migration at early stages of LgDel CNgV development. However, as the ganglion coalesces, proportions of placode-derived LgDel CNgV cells increase relative to neural crest cells. In addition, local aggregation of placode-derived cells increases and aggregation of neural crest-derived cells decreases in LgDel CNgV. This change in cell-cell relationships was accompanied by altered proliferation of placode-derived cells at embryonic day (E)9.5, and premature neurogenesis from neural crest-derived precursors, reflected by an increased frequency of asymmetric neurogenic divisions for neural crest-derived precursors by E10.5. These early differences in LgDel CNgV genesis prefigure changes in sensory neuron differentiation and gene expression by postnatal day 8, when early signs of cranial nerve dysfunction associated with pediatric dysphagia are observed in LgDel mice. Apparently, 22q11 deletion destabilizes CNgV sensory neuron genesis and differentiation by increasing variability in cell-cell interaction, proliferation and sensory neuron differentiation. This early developmental divergence and its consequences may contribute to oropharyngeal dysfunction, including suckling, feeding and swallowing disruptions at birth, and additional orofacial sensory/motor deficits throughout life.
Differential cellular responses to adhesive interactions with galectin-8- and fibronectin-coated substrates
Authors: Li Wenhong , Sancho Ana , Chung Wen-Lu , Vinik Yaron , Groll Jürgen , Zick Yehiel , Medalia Ohad , Bershadsky Alexander D. , Geiger Benjamin
Published: March 2021

The mechanisms underlying the cellular response to extracellular matrices (ECMs) that consist of multiple adhesive ligands are still poorly understood. Here, we address this topic by monitoring specific cellular responses to two different extracellular adhesion molecules – the main integrin ligand fibronectin and galectin-8, a lectin that binds β-galactoside residues  − as well as to mixtures of the two proteins. Compared with cell spreading on fibronectin, cell spreading on galectin-8-coated substrates resulted in increased projected cell area, more-pronounced extension of filopodia and, yet, the inability to form focal adhesions and stress fibers. These differences can be partially reversed by experimental manipulations of small G-proteins of the Rho family and their downstream targets, such as formins, the Arp2/3 complex and Rho kinase. We also show that the physical adhesion of cells to galectin-8 was stronger than adhesion to fibronectin. Notably, galectin-8 and fibronectin differently regulate cell spreading and focal adhesion formation, yet act synergistically to upregulate the number and length of filopodia. The physiological significance of the coherent cellular response to a molecularly complex matrix is discussed.

This article has an associated First Person interview with the first author of the paper.
α-Arrestin ARRDC3 tumor suppressor function is linked to GPCR-induced TAZ activation and breast cancer metastasis
Authors: Arakaki Aleena K. S. , Pan Wen-An , Wedegaertner Helen , Roca-Mercado Ivette , Chinn Logan , Gujral Taranjit S. , Trejo JoAnn
Published: March 2021

The α-arrestin domain containing protein 3 (ARRDC3) is a tumor suppressor in triple-negative breast carcinoma (TNBC), a highly metastatic subtype of breast cancer that lacks targeted therapies. Thus, understanding the mechanisms and targets of ARRDC3 in TNBC is important. ARRDC3 regulates trafficking of protease-activated receptor 1 (PAR1, also known as F2R), a G-protein-coupled receptor (GPCR) implicated in breast cancer metastasis. Loss of ARRDC3 causes overexpression of PAR1 and aberrant signaling. Moreover, dysregulation of GPCR-induced Hippo signaling is associated with breast cancer progression. However, the mechanisms responsible for Hippo dysregulation remain unknown. Here, we report that the Hippo pathway transcriptional co-activator TAZ (also known as WWTR1) is the major effector of GPCR signaling and is required for TNBC migration and invasion. Additionally, ARRDC3 suppresses PAR1-induced Hippo signaling via sequestration of TAZ, which occurs independently of ARRDC3-regulated PAR1 trafficking. The ARRDC3 C-terminal PPXY motifs and TAZ WW domain are crucial for this interaction and are required for suppression of TNBC migration and lung metastasis in vivo. These studies are the first to demonstrate a role for ARRDC3 in regulating GPCR-induced TAZ activity in TNBC and reveal multi-faceted tumor suppressor functions of ARRDC3.

This article has an associated First Person interview with the first author of the paper.
Neuroethology of number sense across the animal kingdom
Authors: Nieder Andreas
Published: March 2021

Many species from diverse and often distantly related animal groups (e.g. monkeys, crows, fish and bees) have a sense of number. This means that they can assess the number of items in a set – its ‘numerosity’. The brains of these phylogenetically distant species are markedly diverse. This Review examines the fundamentally different types of brains and neural mechanisms that give rise to numerical competence across the animal tree of life. Neural correlates of the number sense so far exist only for specific vertebrate species: the richest data concerning explicit and abstract number representations have been collected from the cerebral cortex of mammals, most notably human and nonhuman primates, but also from the pallium of corvid songbirds, which evolved independently of the mammalian cortex. In contrast, the neural data relating to implicit and reflexive numerical representations in amphibians and fish is limited. The neural basis of a number sense has not been explored in any protostome so far. However, promising candidate regions in the brains of insects, spiders and cephalopods – all of which are known to have number skills – are identified in this Review. A comparative neuroscientific approach will be indispensable for identifying evolutionarily stable neuronal circuits and deciphering codes that give rise to a sense of number across phylogeny.
Static Stretching Reduces Motoneuron Excitability: The Potential Role of Neuromodulation
Authors: Trajano Gabriel S. , Blazevich Anthony J.
Published: March 2021

Prolonged static muscle stretching transiently reduces maximal muscle force, and this force loss has a strong neural component. In this review, we discuss the evidence suggesting that stretching reduces the motoneuron's ability to amplify excitatory drive. We propose a hypothetical model in which stretching causes physiological relaxation, reducing the brainstem-derived neuromodulatory drive necessary to maximize motoneuron discharge rates.
Exercise Is Muscle Mitochondrial Medicine
Authors: Oliveira Ashley N. , Richards Brandon J. , Slavin Mikhaela , Hood David A.
Published: March 2021

Exercise stimulates the biogenesis of mitochondria in muscle. Some literature supports the use of pharmaceuticals to enhance mitochondria as a substitute for exercise. We provide evidence that exercise rejuvenates mitochondrial function, thereby augmenting muscle health with age, in disease, and in the absence of cellular regulators. This illustrates the power of exercise to act as mitochondrial medicine in muscle.
Comparison of WHO growth standard and national Indonesian growth reference in determining prevalence and determinants of stunting and underweight in children under five: a cross-sectional study from Musi sub-district
Authors: Flynn Jeannie , Alkaff Firas Farisi , Sukmajaya William Putera , Salamah Sovia
Published: March 2021

Background:Determination of stunting and wasting always uses the WHO growth standard in Indonesia. However, it is believed that Indonesian children are “below” the global standard, thus the WHO standard is not reliable to present the actual prevalence. This study aims to compare the prevalence and determinants of stunting and underweight using WHO growth standard and national Indonesian growth reference.

Methods:This was a cross-sectional study carried out in Musi sub-district, East Nusa Tenggara province in July 2019. East Nusa Tenggara province had the highest prevalence of stunting and underweight in Indonesia. The study population were children under five, and total sampling method was used for this study. Length/height-for-age and weight-for-age were plotted using WHO standard and national Indonesian reference. Univariate and multivariate binomial logistic regression were used for statistical analysis.

Results:The prevalence of stunting and underweight were higher for the WHO standard than the national reference (53.9% vs 10.7% and 29.17% vs 17.7%; all p < 0.001). After adjusted for confounding factors, when the WHO standard was used, determinants of stunting were maternal mid-upper arm circumference below 23.5cm and maternal height below 150cm; determinants of underweight were intrauterine growth restriction, young maternal age during pregnancy, and multiple parities. When the national reference was used, no determinants was found for stunting; the determinants of underweight were intrauterine growth restriction and maternal education.

Conclusions:The WHO standard is not suitable for representing child growth in Musi sub-district. Future studies should be done to re-evaluate the prevalence and determinants of stunting and underweight nationwide using the national Indonesian reference.
Development of a physiologically based pharmacokinetic (PBPK) model of psilocybin and psilocin from magic mushroom in rats and humans
Authors: Musikaphongsakul Prinya , Ya Kimheang , Subsoontorn Pakpoom , Lohitnavy Manupat
Published: March 2021

Background: Psilocybin (PB) is a psychoactive compound commonly found in magic mushroom (Psilocybe cubensis). PB is quickly converted by the body to psilocin (PI), which has a psychedelic effect through the activation of the 5-HT2A receptor in the brain. The objective of this study is to develop a physiologically based pharmacokinetic (PBPK) model of PB and PI in rats and humans for predicting concentrations of the psychoactive substance in the brain.

Methods: Following a search in PubMed, three studies were retrieved and information concerning concentration-time profiles of PI were extracted from the selected studies. In the study in rats, PI was orally administered with a dose of 10.1 mg/kg. There were two studies in humans following a single intravenous dose of PB (1 mg) and oral dose of PB (0.224 mg/kg and 0.3 mg/kg). Berkeley Madonna software was used for computer coding and simulations. The developed PBPK model consisted of seven organ compartments (i.e. lung, heart, brain, fat, muscle, kidney, and liver).

Results: The simulations show a good agreement between observed and simulated data, although results for oral administration in rats and humans showed under-predictions and results for intravenous administration in humans showed over-predictions.

Conclusions: A PBPK model of PB and PI in rats and humans was developed and could predict concentration-time profiles of PI in plasma, particularly in the brain, following intravenous and oral administration of PB. This model may be useful for a safer dosage regimen of PB for patients with some disorders.
Fundamentals of Psychology (textbook for non-core specialties)
Authors: Dolganov D.N.
Published: March 2021

Пособие содержит краткий теоретический материал и задания для самостоятельной работы по основным темам дисциплин «Психология», «Основы психологии» читаемых студентам специальностей «Экономика и управление», «Менеджмент», «Юриспруденция». Рекомендуется студентам для использования в учебных целях.
Philosophy: a collection of tasks and exercises
Authors: Komarova E.V.
Published: March 2021

Учебное издание составлено в соответствии с программой дисциплины «философия», имеет контрольно-обучающий характер и содержит задания и тесты по ключевым проблемам философии. Учебное издание предназначено для обучающихся по направлению подготовки 02.03.02 Фундаментальная информатика и информационные технологии, 37.03.01 Психология, 38.03.01 Экономика, 38.03.02 Менеджмент, 40.03.01 Юриспруденция, 44.03.01 Педагогическое образование. Будет полезно обучающимся других направлений подготовки, преподавателям вузов.
Physical culture: textbook
Authors: Kuzmina N.S.
Published: March 2021

Учебное пособие разработано по дисциплине «Физическая культура». Пособие содержит теоретические сведения в области физической культуры и спорта, практические задания, которые помогут студентам сформировать систему знаний по основам физического воспитания, профессионально-прикладной физической подготовки, здоровому образу жизни, организации самостоятельных занятий и др., которая позволит им в будущей профессиональной деятельности правильно использовать средства физической культуры и спорта. Предназначается обучающимся дневной формы обучения всех специальностей БИФ КемГУ.
Sobre instituciones, ideas y ausencias en el análisis neodesarrollista. Algunos aportes surgidos de la experiencia argentina
Authors: Seiler Cristhian
Published: March 2021

Los análisis más importantes de las variedades capitalistas en América Latina re­flexionaron en torno al carácter jerárquico y predominante del capital transnacional o bien a la centralidad estratégica del Estado en su versión neodesarrollista frente a su precedente neoliberal. No obstante, dada la persistencia de las características estructu­rales periféricas habituales (en particular transnacionalización económica) y el ‘giro a la derecha’, es posible señalar que la desconsideración de la trayectoria histórico-estructural de los países latinoamericanos y el contexto hegemónico neoliberal en el que las res­puestas estatales tuvieron lugar han vedado una interpretación más adecuada de tales experiencias latinoamericanas recientes. Con referencia a la experiencia argentina, el trabajo sugiere que la profundización del dominio transnacional y la marginación de otros actores productivos como las pymes no debería ser visto como una falla institucional, sino como una forma específica de funcionamiento estatal en el contexto periférico. Al respecto, este análisis vincula la intervención estatal con la incidencia de los organismos internacionales (por ejemplo, el Banco Mundial o Banco Interamericano de Desarrollo) como nodos difusores de ideas y enfoques de política centradas en una ‘competitividad correcta’ que ha inducido al Estado a actuar condicionalmente en función del dominio transnacional de la estructura productiva doméstica.
The Development of Motivation of Linguistic and Professional Training of Higher Education Students in the Conditions of Distance Learning
Authors:   State Higher Educational Institution ", Panasenko Ellina ,   Donbas State Pedagogical University", Vnukova Anhelina ,   State Institution Luhansk Taras Shevchenko National University
Published: March 2021

The article investigates the problem of developing motivation for learning of higher education students in the process of linguistic and professional training in the conditions of distance learning. Motivation for learning is interpreted as a system of external and internal motives for learning, the hierarchy and interaction of which is formed under the influence of pedagogical conditions, has a multilevel structure, the formation levels of which can be assessed by a certain criteria and indicators. The specific factors of motivation for learning are characterized, the reasons for the motivation decrease of students of non-language specialities when studying a foreign language are regarded. The necessity of realizing the principles of subjectivity, professionally-oriented technological effectiveness, interactivity, independence (autonomy), communicativeness, consciousness, accessibility, and stages in the linguistic and professional development of students in the conditions of distance learning is proved. The active introduction of distance learning technologies to the education system of Ukraine is emphasized. The distance learning is interpreted as a system of professionally oriented training of students constructed in a certain way in the Internet environment. The effectiveness of distance learning and the specifics of designing individual educational routes of higher education students are substantiated. The main tasks and imperatives of linguistic and professional training of future specialists are determined. The special importance of improving the goals, content, forms and methods of teaching in order to increase motivation for learning of students is emphasized.
Production of Antioxidant Bioactive Compounds during Mycelium Growth of Schizophyllum commune on Different Cereal Media
Authors: Boonthatui Yossarun , Chongsuwat Rewadee , Kittisakulnam Somchoke
Published: March 2021

Schizophyllum commune or split gill mushroom is a nutrient-rich natural food ingredient. Even during mycelium growth, S. commune could produce the bioactive compounds including phenolic and flavonoid compounds. The aim of this research was to characterize the production of bioactive compounds during mycelium growth period of S. commune cultured onto different eight edible cereal media (sorghum, corn, barley, wheat, oat, jasmine rice, Mun Poo rice and riceberry rice). The antioxidant activities and mycelial biomass were also observed during their growth. The results show that the highest mycelial growth rate was obtained onto barley and jasmine rice, while the lowest one was found in sorghum and corn. The concentration of phenolic compounds increased along with the mycelial growth. The fungal culture on wheat significantly exhibited the highest production of phenolic compounds which was 8.56 ± 1.09 mg GAE/g DW on day 8.The highest flavonoid production of 577.35 ± 29.93 μg CE/g DW, wasremarkably found onto barley from day 6. The degradation of certain flavonoidsin cereal materials by S. commune was also observed, particularly in riceberryrice. Antioxidant activity of cultured cereals was depended on the initial activitiesof materials and was mainly increased by S. commune metabolism. The DPPH•and ABTS•+ scavenging activities were sharply increased at day 4 which was earlystage of log phase of S. commune. At day 8, most of cereal media exhibited highDPPH• activity with a half maximal inhibitory concentration (IC50) range of 3.83-5.80 mg DW/mL, except jasmine rice. Only wheat and oat could significantly givethe highest ABTS•+ scavenging activity which was in an IC50 range of 2.38-3.27mg DW/mL. The highest FRAP activity with a median effective concentration (EC50)of 2.14 ± 0.23 mg DW/mL, was observed in barley which corresponded with itshighest flavonoid content. Antioxidant activities of S. commune culture onto cerealmedia were correspondent with their phenolic and flavonoid contents. Therefore,this study assured that several antioxidative substances were interestinglyproduced by using S. commune cultured onto the selected edible cereals, whichcould be possibly developed as a new supplement or active ingredient forpharmaceutical and food industries.
Physicochemical and Nutritional Properties of Nixtamalized Quality Protein Maize Flour and its Potential as Substitute in Philippine Salt Bread
Authors: Sunico Dianne Jane A. , Rodriguez Felicito M. , Tuaño Arvin Paul P. , Mopera Lotis E. , Atienza Liezl M. , Juanico Clarissa B.
Published: March 2021

Nixtamalization is an ancient method of processing corn that is said to enhance the nutritional value of maize by improving protein quality, increasing calcium and niacin bioavailability, and reducing phytic acid levels, thus increasing iron digestibility and biovailability. The main objective of this study was to determine the effect of different nixtamalization processes on the physicochemical and nutritional properties of quality protein maize (QPM) flour and evaluate its potential and acceptability as a flour substitute in Philippine salt bread baking, determined through sensory analysis. Three processes of nixtamalization were employed, namely, traditional, classic, and ecological. Nixtamalized QPM flours, combined with wheat flour in 30:70 ratio, were used in the product development and sensory evaluation of Philippine salt bread. Results revealed that nixtamalization contributed significantly in the pH, color, and particle size of nixtamalized QPM flours. There was a significant increase (P ≤0.05) in the moisture, crude protein, crude fiber, crude ash, calcium, iron, niacin, lysine, tryptophan, total starch, amylose, amylopectin, resistant starch, and soluble fiber contents and a significant decrease in the crude fat, nitrogen-free extract (NFE), phytate, and insoluble fiber contents of QPM flours after nixtamalization. No significant difference was found in the zinc and total dietary fiber contents among the samples. The Philippine salt bread produced using nixtamalized QPM flours had a high overall acceptability based on two-step sensory analysis. QPM is greatly improved by the ancient technology of nixtamalization and nixtamalized QPM flour showed desirable contributions in terms of the nutritional value and sensory attributes of Philippine salt bread when used as a flour substitute or blend.
Evaluation of the Antioxidant Activity of Bignay (Antidesma bunius (Linn.) Spreng var. Kalabaw) Flesh and Seeds as Affected by Maturity and Processing Method
Authors: Sartagoda Kristel June , Ilano Ma. Cristina , Flandez Lloyd Earl , Castillo-Israel Katherine Ann
Published: March 2021

This study aimed to determine the influence of maturity stages and processing methods (blanching and steaming) on the antioxidant profile and in vitro antioxidant activities of bignay (Antidesma bunius (Linn.) Spreng var. Kalabaw) flesh and seeds. Bignay fruits of three maturities (unripe, half ripe, and fully ripe) were collected from Laguna, Philippines. Each maturity stage was subdivided into three lots. One lot underwent blanching at 90 ± 5°C for 2 minutes, and another underwent steaming at 105 ± 5°C for 5 minutes while the last did not undergo treatment. Seeds of the samples were then separated from the flesh. Both seeds and flesh were freeze-dried, extracted, and analyzed for antioxidant contents (total phenolic content, total flavonoid content, and total anthocyanin content) and antioxidant activity by DPPH, ABTS, and FRAP assays. Results show that both the maturity and processing methods significantly affect the antioxidant content and activity of the samples. Moreover, except for the FRAP assay done on flesh samples, all assays showed that there is significant interaction between the effect of maturity and processing method on the antioxidant contents and activity of bignay flesh and seeds. Results also show that fully ripe flesh and seeds yielded greater antioxidant content and antioxidant activity than their half-ripe and unripe counterparts; whereas, blanched flesh and seeds generally had higher antioxidant activities than their unprocessed and steamed counterparts.
Radiation exposure during the treatment of spinal deformities
Authors: Mehta Jwalant S. , Hodgson Kirsten , Yiping Lu , Kho James Swee Beng , Thimmaiah Ravindra , Topiwala Upasana , Sawlani Vijay , Botchu Rajesh
Published: March 2021

Aims

To benchmark the radiation dose to patients during the course of treatment for a spinal deformity.

Methods

Our radiation dose database identified 25,745 exposures of 6,017 children (under 18 years of age) and adults treated for a spinal deformity between 1 January 2008 and 31 December 2016. Patients were divided into surgical (974 patients) and non-surgical (5,043 patients) cohorts. We documented the number and doses of ionizing radiation imaging events (radiographs, CT scans, or intraoperative fluoroscopy) for each patient. All the doses for plain radiographs, CT scans, and intraoperative fluoroscopy were combined into a single effective dose by a medical physicist (milliSivert (mSv)).

Results

There were more ionizing radiation-based imaging events and higher radiation dose exposures in the surgical group than in the non-surgical group (p < 0.001). The difference in effective dose for children between the surgical and non-surgical groups was statistically significant, the surgical group being significantly higher (p < 0.001). This led to a higher estimated risk of cancer induction for the surgical group (1:222 surgical vs 1:1,418 non-surgical). However, the dose difference for adults was not statistically different between the surgical and non-surgical groups. In all cases the effective dose received by all cohorts was significantly higher than that from exposure to natural background radiation.

Conclusion

The treatment of spinal deformity is radiation-heavy. The dose exposure is several times higher when surgical treatment is undertaken. Clinicians should be aware of this and review their practices in order to reduce the radiation dose where possible. Cite this article: Bone Joint J 2021;103-B(4):1–7.
The continuum of symbolic violence: how sexting education neglects image-based sexual abuse, dismisses perpetrators’ responsibility, and violates rights to sexual autonomy
Authors: Zauner Julia
Published: March 2021

In the last decade there has been an increased interest in (young) people’s sexting behaviour from academia, media and other institutions which lead to the emergence of sexting safety campaigns. Sexting campaigns are often built around notions of dangers when images are shared without the consent of the person depicted. This feminist case study will critically assess the discourses of three UK educational campaigns (Exposed, Sexting, Just send it) to demonstrate how these campaigns are currently (re)producing symbolic violence through victim-blaming and are thus legitimising violence against women; the seriousness of image-based sexual abuse is neglected through the penalisation of sexual expression of particularly young women; the dominance of heteronormative depictions of female survivors and male perpetrators obfuscates abuse as an experience across all social groups; and survivors are consistently held accountable for their own victimisation while perpetrators are excused for violating their partners trust and integrity. However, by neutralising and denying responsibility, educational work dismisses 1) that image-based sexual abuse is still as a form of gender-based violence and therefore, breaches the survivor’s rights to dignity and bodily/sexual autonomy, and 2) young people’s rights to explore sexuality – through digital means or not – in a safe environment.
Specific detection of glucose by an optical weak measurement sensor
Authors: Xu Yang , Shi Lixuan , Guan Tian , Guo Cuixia , Zhong Suyi , Zhou Chongqi , Zhang Hailong , Li Zhangyan , Xing Xinhui , Ji Yanhong , Xie Wenyue , Liu Le , He Yonghong
Published: March 2021

Diabetes is an important public health problem and finding quick testing methods with high accuracy, reliability, and convenience are important to control the blood glucose of diabetic patients. In this study, a sensor based on a weak measurement scheme was developed for the specific detection of glucose for the first time. The detection of glucose using the proposed method was completed by the high sensitivity and resolution of the weak measurement based on optical rotation detection, as well as the change in the optical rotation before and after the specific oxidation of glucose. The resolution of the as-obtained glucose sensor was around 2.71×10−3 g/L (1.50×10−2 mmol/L), and the detection range was 0–11 g/L (0–61 mmol/L).
Frozen mode in coupled silicon ridge waveguides for optical true time delay applications
Authors: Paul Banaful , Nahar Niru K. , Sertel Kubilay
Published: March 2021

We propose a simple photonic waveguide structure that exhibits light propagation modes with vanishing group velocity via mode degeneracy. This enables stationary inflection point dispersion leading to the frozen mode and a true time delay device suitable for ultra-wide-band beamforming for millimeter wave (mmWave) phased arrays. The structure consists of three silicon ridge waveguides in proximity with periodic gaps introduced in the outer waveguides to create a band gap. The structure is complementary metal–oxide–semiconductor compatible with a very small footprint of only about

56

µ

m

2

and more resilient to fabrication uncertainties as compared to the previously studied structures. Simulation results show transmission of 70% of the incident wave for the frozen mode at the 1.55 µm (193.6 THz) wavelength through the waveguide. It also enables a delay-bandwidth product of 6.75 along with unprecedented frequency independent bandwidth of about 0.5 THz for RF-mmWave–terahertz beamforming.
Helium-4 magnetometers for room-temperature biomedical imaging: toward collective operation and photon-noise limited sensitivity
Authors: Fourcault William , Romain Rudy , Le Gal Gwenael , Bertrand François , Josselin Vincent , Le Prado Matthieu , Labyt Etienne , Palacios-Laloy Agustin
Published: March 2021

Optically-pumped magnetometers constitute a valuable tool for imaging biological magnetic signals without cryogenic cooling. Nowadays, numerous developments are being pursued using alkali-based magnetometers, which have demonstrated excellent sensitivities in the spin-exchange relaxation free (SERF) regime that requires heating to >100 °C. In contrast, metastable helium-4 based magnetometers work at any temperature, which allows a direct contact with the scalp, yielding larger signals and a better patient comfort. However former 4He magnetometers displayed large noises of >200 fT/Hz1/2 with 300-Hz bandwidth. We describe here an improved magnetometer reaching a sensitivity better than 50 fT/Hz1/2, nearly the photon shot noise limit, with a bandwidth of 2 kHz. Like other zero-field atomic magnetometers, these magnetometers can be operated in closed-loop architecture reaching several hundredths nT of dynamic range. A small array of 4 magnetometers operating in a closed loop has been tested with a successful correction of the cross-talks.
Single-celled multifunctional metasurfaces merging structural-color nanoprinting and holography
Authors: Liang Congling , Deng Liangui , Dai Qi , Li Zile , Zheng Guoxing , Guan Zhiqiang , Li Gongfa
Published: March 2021

Nanostructured metasurfaces applied in structural-color nanoprinting and holography have been extensively investigated in the past several years. Recently, merging them together is becoming an emerging approach to improve the information capacity and functionality of metasurfaces. However, current approaches, e.g., segmenting, interleaving and stacking schemes for function merging, suffer from crosstalk, low information density, design and fabrication difficulties. Herein, we employ a single-celled approach to design and experimentally demonstrate a high-density multifunctional metasurface merging nanoprinting and holography, i.e., each nanostructure in the metasurface can simultaneously manipulate the spectra (enabled with varied dimensions of nanostructures) and geometric phase (enabled with varied orientation angles of nanostructures) of incident light. Hence, with different decoding strategies, a structural-color nanoprinting image emerges right at the metasurface plane under white light illumination, while a holographic image is reconstructed in the Fraunhofer diffraction zone under circularly polarized laser light incidence. And the two images have no crosstalk since they are independently designed and presented at different distances. Our proposal suggests a space-multiplexing scheme to develop advanced metasurfaces and one can find their markets in high-density information storage, optical information encryption, multi-channel image display, etc.