bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of demographic, clinical, and treatment compliance characteristics on quality of life of Venezuelan patients with systemic lupus erythematosus
Authors: Carrión-Nessi Fhabián S. , Marcano-Rojas María V. , Romero Arocha Sinibaldo R. , Mendoza Millán Daniela L. , Forero-Peña David A. , Antuarez-Magallanes Allen W. , Al Snih Soham , Rodríguez Martín A. , Fuentes-Silva Yurilís J.
Published: January 2022

Background

We have here assessed the impact of demographic, clinical, and treatment compliance characteristics on health-related quality of life (HRQoL) of Venezuelan patients with systemic lupus erythematosus (SLE). We have used a disease-specific questionnaire, the Lupus Quality of Life (LupusQoL), validated in our patient population, to measure HRQoL.

Methods

A cross-sectional study was conducted among 100 patients with SLE from outpatient clinics. Patients completed a form with demographic, clinical, and treatment compliance data, and the LupusQoL questionnaire. HRQoL was classified as better or worse according to previously established cut-off points for this patient population. Spearman’s r test was used to determine the correlations between age, years of education, disease duration, SLEDAI, and SLICC-DI with the eight domains of the LupusQoL. Mann–Whitney U test was used to compare the HRQoL between the two groups of patients according to treatment compliance. Binomial logistic regression using the backward stepwise selection method was performed to identify the risk factors associated with each of the eight domains of the LupusQoL among patients with inactive (SLEDAI < 4) and active (SLEDAI ≥ 4) SLE.

Results

HRQoL of our patients was classified as better in all domains of the LupusQoL. Age correlated negatively with all domains of the LupusQoL, except with “burden to others”, and disease activity correlated negatively with all domains of the LupusQoL, except with “intimate relationships” and “burden to others” (p < 0.05). Patients who fully complied with indicated treatment had higher scores in “physical health” domain compared to patients who did not comply with at least one of the prescribed medications (p < 0.05). In patients with active SLE, a risk factor associated with worse “planning” and “intimate relationships” was advanced age, while having had SLE flare-ups in the previous six months was a risk factor associated with worse “physical health” (p < 0.05).

Conclusion

Age and disease activity were negatively correlated with almost all domains of the LupusQoL, and treatment compliance was associated with higher score in the “physical health” domain. Disease control and treatment compliance should be the main goals for a better HRQoL in our patients with SLE.
Effects of short-term environmental stresses on the onset of cannabinoid production in young immature flowers of industrial hemp (Cannabis sativa L.)
Authors: Park Sang-Hyuck , Pauli Christopher S. , Gostin Eric L. , Staples S. Kyle , Seifried Dustin , Kinney Chad , Vanden Heuvel Brian D.
Published: January 2022

Backgrounds

Cannabis sativaL. produces at least 120 cannabinoids. Although genetic variation is the main factor in cannabinoid production, the effects of short-term environmental stresses in the early flowering stage remains largely unknown.

Methods

To investigate the effects of short-term environmental stresses on the onset of cannabinoid production in young immature flowers, a hemp variety, Green-Thunder (5–8% CBD/mg of dry weight), was treated with mechanical damage, insect herbivory, extreme heat, or drought stress for 5–7 days during the first 2 weeks of flowering. Three hemp tissues, including flowers, leaves, and stems, were collected from hemp grown under these stress conditions at multiple time points during the first 2 weeks after transition to the short photoperiod and analyzed using high pressure liquid chromatography to quantify phytocannabinoids including cannabigerolic acid (CBGA), cannabigerol (CBG), cannabidiolic acid (CBDA), cannabidiol (CBD), Δ-tetrahydrocannabinolic acid (THCA), Δ-tetrahydrocannabinol (THC), and cannabinol (CBN).

Results

The 5 days of mechanical wounding did not affect the production of any of the cannabinoids during the initial stage of flowering. However, after 5 days of herbivore treatment, there was a significant difference in concentration between day 1 and day 6 of CBGA (control: 308 μg/g; treatment – 24 μg/g), CBG (control: 69 μg/g; treatment: 52 μg/g), and CBD (control: 755 μg/g; treatment: 194 μg/g) between the control and treatment plants. The 7 days of heat treatment at 45–50oC significantly reduced the production of CBGA during this observed window (control: 206 μg/g; treatment: 182 μg/g) and CBG (control: 21 μg/g; treatment: − 112 μg/g). Notably, the largest change was observed after 7 days of drought stress, when plants showed a 40% greater accumulation of CBG (control: 336 μg/g; treatment: 622 μg/g), and a significant decrease (70–80%) in CBD (control: 1182 μg/g; treatment: 297 μg/g) and THC amounts (control: 3927 μg/g; treatment: 580 μg/g).

Conclusions

Although this observation is limited in the early flowering stage, the common field stresses are adequate to induce changes in the cannabinoid profiles, particularly drought stress being the most impactful stress for hemp flower initiation with the altering the cannabinoid production by decreasing CBD and THC accumulation while increasing CBG by 40%.
Therapy development for spinal muscular atrophy: perspectives for muscular dystrophies and neurodegenerative disorders
Authors: Jablonka Sibylle , Hennlein Luisa , Sendtner Michael
Published: January 2022

Background

Major efforts have been made in the last decade to develop and improve therapies for proximal spinal muscular atrophy (SMA). The introduction of Nusinersen/Spinraza™ as an antisense oligonucleotide therapy, Onasemnogene abeparvovec/Zolgensma™ as an AAV9-based gene therapy and Risdiplam/Evrysdi™ as a small molecule modifier of pre-mRNA splicing have set new standards for interference with neurodegeneration.

Main body

Therapies for SMA are designed to interfere with the cellular basis of the disease by modifying pre-mRNA splicing and enhancing expression of the Survival Motor Neuron (SMN) protein, which is only expressed at low levels in this disorder. The corresponding strategies also can be applied to other disease mechanisms caused by loss of function or toxic gain of function mutations. The development of therapies for SMA was based on the use of cell culture systems and mouse models, as well as innovative clinical trials that included readouts that had originally been introduced and optimized in preclinical studies. This is summarized in the first part of this review. The second part discusses current developments and perspectives for amyotrophic lateral sclerosis, muscular dystrophies, Parkinson's and Alzheimer's disease, as well as the obstacles that need to be overcome to introduce RNA-based therapies and gene therapies for these disorders.

Conclusion

RNA-based therapies offer chances for therapy development of complex neurodegenerative disorders such as amyotrophic lateral sclerosis, muscular dystrophies, Parkinson’s and Alzheimer’s disease. The experiences made with these new drugs for SMA, and also the experiences in AAV gene therapies could help to broaden the spectrum of current approaches to interfere with pathophysiological mechanisms in neurodegeneration.
Performance evaluation of digital mammography, digital breast tomosynthesis and ultrasound in the detection of breast cancer using pathology as gold standard: an institutional experience
Authors: Joshi Pranjali , Singh Neha , Raj Gaurav , Singh Ragini , Malhotra Kiran Preet , Awasthi Namrata Punit
Published: January 2022

Background

Mammography is the primary imaging modality for diagnosing breast cancer in women more than 40 years of age. Digital breast tomosynthesis (DBT), when supplemented with digital mammography (DM), is useful for increasing the sensitivity and improving BIRADS characterization by removing the overlapping effect. Ultrasonography (US), when combined with the above combination, further increases the sensitivity and diagnostic confidence. Since most of the research regarding tomosynthesis has been in screening settings, we wanted to quantify its role in diagnostic mammography. The purpose of this study was to assess the performance of DM alone vs. DM combined with DBT vs. DM plus DBT and ultrasound in diagnosing malignant breast neoplasms with the gold standard being histopathology or cytology.

Results

A prospective study of 1228 breasts undergoing diagnostic or screening mammograms was undertaken at our institute. Patients underwent 2 views DM, single view DBT and US. BIRADS category was updated after each step. Final categorization was made with all three modalities combined and pathological correlation was done for those cases in which suspicious findings were detected, i.e. 256 cases. Diagnosis based on pathology was done for 256 cases out of which 193 (75.4%) were malignant and the rest 63 (24.6%) were benign. The diagnostic accuracy of DM alone was 81.1%. Sensitivity, Specificity, PPV and NPV were 87.8%, 60%, 81.3% and 61.1%, respectively. With DM + DBT the diagnostic accuracy was 84.8%. Sensitivity, Specificity, PPV and NPV were 92%, 56.5%, 89% and 65%, respectively. The diagnostic accuracy of DM + DBT + US was found to be 85.1% and Sensitivity, Specificity, PPV and NPV were 96.3%, 50.7%, 85.7% and 82%, respectively.

Conclusion

The combination of DBT to DM led to higher diagnostic accuracy, sensitivity and PPV. The addition of US to DM and DBT further increased the sensitivity and diagnostic accuracy and significantly increased the NPV even in diagnostic mammograms and should be introduced in routine practice for characterizing breast neoplasms.
Negative renal angiography with subsequent denied angioembolization: findings in a series of 180 patients at a tertiary interventional uroradiology unit
Authors: Farg Hashim Mohamed , Elawdy Mohamed Mohamed , Soliman Karim Ali , Badawy Mohamed Ali , Elsorougy Ali , Mohsen Tarek , El-Diasty Tarek , Abdelhamid Abdalla
Published: January 2022

Background

Renal arterial embolization (RAE) is considered to be a safe and effective method for treating a variety of renal lesions and pathology. It is the optimal method not only to stop bleeding, but to preserve renal parenchyma and renal function. Patients who are scheduled to RAE who showed negative catheter angiography with the procedure subsequently denied have a special concern because they are subjected to unnecessary procedure with its complications and didn’t get its benefits. This circumstance is infrequently reported in the literature, and that compelled us to identify the predictors of negative renal angiography findings that would result in a failure to undertake RAE.

Results

The study included 180 patients (126 males; 70%) with a mean ± SD age of 44 ± 14 years. Iatrogenic causes were the most common indication for RAE (108 of 180; 60%), while spontaneous unknown reasons constituted (17 of 180 patients; 9%). Angiography showed various lesions in 148 patients: pseudoaneurysm (80 of 148; 54%), tumours (28 of 148; 19%), arteriovenous (AV) fistulas (22 of 148; 15%)
and both pseudoaneurysm and AV fistulas (18 of 148; 12%). However, in the remaining 32 of 180 patients (18%) no lesions were identified on renal angiography and RAE procedures were not undertaken. On bivariate analysis, neither gender, side of the lesions, haematuria prior to RAE, or renal artery anatomy were predictors for negative angiography. However, the indication for RAE (spontaneous unknown reasons) of renal haemorrhage was the only predictor for negative angiography (9/17 (53%), P = 0.001).

Conclusion

Patients scheduled for RAE may show negative findings with no lesions on renal angiography. Among the different indications for RAE, patients with spontaneous (unknown) have the highest probability (53%) of being associated with negative renal angiography findings, however, those with renal tumours and post-traumatic causes have a low probability. In those patients with spontaneous (unknown), conservative management should be the initial treatment of choice in order to avoid unnecessary RAE and its associated complications.
The value of inflow inversion recovery MRI for the diagnosis of transplant renal artery stenosis: comparison with digital subtraction angiography
Authors: Li Hongxia , Shao Guangrui , Zhao Yuan , Zhong Hai
Published: January 2022

Background

To date, few data on the assessment of transplant renal artery stenosis (TRAS) by using inflow inversion recovery (IFIR) are available. The aims of this study was to evaluate the feasibility of IFIR in the assessment of TRAS using Digital Subtraction Angiography (DSA) as the reference.

Results

We retrospectively assessed the IFIR of 195 transplant renal arteries. The IFIR images for 194/195 arteries were judged to be of excellent, good, or moderate quality, and 1/195 was not diagnostic. There were 100 arteries with TRAS, of which 27 were subjected to DSA. The stenosis percentages were divided into five grades. Using DSA images, the TRAS in 27 patients were estimated as grade 1 (2, 7.4%), grade 2 (8, 29.6%), grade 3 (10, 37.0%), grade 4 (7, 25.9%) and grade 5 (0, 0%). In comparison, the TRAS was shown to be grade 1 (1, 3.7%), grade 2 (8, 29.6%), grade 3 (9, 33.3%), grade 4 (9, 33%) and grade 5 (0, 0%) in the IFIR images. The nonparametric Wilcoxon signed-rank test was used to compare IFIR with DSA. In addition, a Bland–Altman plot was used to estimate the agreement between IFIR and DSA measurements. There was no significant difference between IFIR and DSA measurements (p < 0.05).

Conclusions

Relative to the reference DSA, IFIR was shown to be noninvasive, accurate for the diagnosis and evaluation of TRAS.
Rapid diagnosis of Toxoplasma gondii using loop-mediated isothermal amplification assay in camels and small ruminants
Authors: Zeedan Gamil S. G. , Abdalhamed Abeer M. , Shaapan Raafat M. , El-Namaky Amira H.
Published: January 2022

Background

This study was conducted to detect the presence of T. gondii in milk and blood samples using three different assays: enzyme-linked immunosorbent assay (ELISA), polymerase chain reaction (PCR), and loop-mediated isothermal amplification assay (LAMP). Whole blood, serum, and milk samples were collected from goats (n = 156), sheep (n = 261), and camels (n = 108) in different governorates in Egypt from December 2019 to February 2021 and screened by ELISA for anti-Toxoplasma IgG antibodies before DNA extraction. The target T. gondii DNA gene was detected and evaluated using the LAMP assay compared to PCR.

Results

T. gondii antibodies were found in milk and serum samples at the rates of (29.26%) and (36.58%) in camels, (34.18%) and (35.89%) in sheep, and (33.7%) and (36.36%) in goats, respectively. Similar to PCR, the percentages of LAMP tests for the detection of the T. gondii DNA gene in milk and blood samples of camels, sheep, and goats were (4.8, 14.63), (6.83, 7.69), and (7.79, 9.09), respectively. LAMP's sensitivity for detecting T. gondii in milk and blood samples, which was identical to that of PCR, was 100%.

Conclusions

The findings clearly demonstrated that there were no variations in T. gondii detection capabilities in milk and blood samples from various animals using both PCR and LAMP tests. It provides a quick, precise, and sensitive method of detecting T. gondii in a variety of samples that may be used both in the field and in laboratory diagnosis.
A novel simultaneous high performance liquid chromatography-PDA method for the determination of Tenofovir AF, Darunavir, Emtricitabine and Cobicistat in bulk and its application to marketed formulation
Authors: Pavani Challamalla , Susithra E.
Published: January 2022

Background

The present research article involves the simultaneous determination of Tenofovir alafenamide, Darunavir, Emtricitabine and Cobicistat in bulk as well as in tablet dosage form using high performance liquid chromatography.

Result

The separation was performed using DIKMA Spursil, C18, ODS, (4.6 × 150 mm × 5 µm) analytical column using the mobile phase acetonitrile and 0.1% Orthophosphoric acid in the volume ratio of 70:30 at pH 3. The eluents were detected using PDA detector at 254.0 nm. After optimization subsequent validation study of different parameters was performed by utilizing the optimised condition as per the ICH guidelines. Under this optimised conditions Tenofovir alafenamide, Darunavir, Emtricitabine and Cobicistat were eluted at 2.287 min, 2.507 min, 4.062 min, 6.011 min respectively. Percentage assay was found 99.21% for Tenofovir alafenamide, 99.80% for Darunavir, 99.80% for Emtricitabine and 99.84% for Cobicistat. Tenofovir alafenamide was found linear in the range of 2.0–10.0 µg/mL, Darunavir (160.0–800.0 µg/mL), Emtricitabine (40.0–200.0 µg/mL) and for cobicistat (30.0–150.0 µg/mL). The corelation coefficient was found 0.999 for all the APIs. The detection limit was found 0.14 µg/mL for Tenofovir alafenamide, 2.14 µg/mL for Darunavir, 0.6 µg/mL for Emtricitabine and 7.32 µg/mL for cobicistat. In the LOQ study the quantitation limit was found 0.47 µg/mL for Tenofovir alafenamide, 7.12 µg/mL for Darunavir, 2.10 µg/mL, for Emtricitabine and 24.42 µg/mL for cobicistat.

Conclusion

All the studied API’s has been highly resolute utilizing the optimised condition and found extremely suitable for the determination of all of them simultaneously in marketed dosage form as well as in the bulk form.
Stratigraphic characterization of the Eagle Ford shale to identify the best landing zone: A semianalytical workflow
Authors: Sahoo Ajit K. , Vishal Vikram , Srivastava Mukul
Published: January 2022

Placement of the horizontal well within the best landing zone is critical to maximize well productivity; thus, identification of the best landing zone is important. This paper illustrated an integrated semianalytical workflow to carry out the stratigraphic characterization of the Eagle Ford shale to identify the best landing zone. The objective of this work is twofold: (1) to establish a workflow for stratigraphic characterization and (2) to understand the local level variability in the well performance. To establish the workflow, we have used the production data, petrophysical information, and regional reservoir property maps. As a first step of the workflow, we subdivided the Eagle Ford shale into nine smaller stratigraphic units using the wireline signatures and outcrop study. In the second step, we have used statistical methods such as linear regression, fuzzy groups, and theory of granularity to capture the relationship between the geologic parameters and the well performances. In this step, we identified volume of clay (Vclay), hydrocarbon filled porosity (HCFP), and total organic carbon (TOC) as key drivers of the well performance. In the third step, we characterized the nine smaller units and identified four stratigraphic units as good reservoirs with two being the best due to their low Vclay: high HCFP and high TOC content. Finally, we reviewed the well paths of four horizontal wells with respect to the best stratigraphic units. We observed that the production behavior of these wells was possibly driven by their lateral placement. The better producing wells were placed within the middle of the best stratigraphic units, whereas the poor wells were going out the best stratigraphic units. This investigation provided a case study that demonstrated the importance of integrating data sets to identify best landing zones, and the suggested workflow could be applied to other areas and reservoirs to better identify targetable zones.
Unlocking ultra-high-density seismic for CCUS applications by combining nimble nodes and agile source technologies
Authors: Ourabah Amine , Chatenay Allan
Published: January 2022

In the quest for denser, nimbler, and lower-cost seismic surveys, the industry is seeing a revolution in the miniaturization of seismic equipment, with autonomous nodes approaching the size of a geophone and sources becoming portable by crews on foot. This has created a paradigm shift in the way seismic is acquired in difficult terrains, making zero-environmental-footprint surveys a reality while reducing cost and health, safety, and environmental risk. The simplification of survey operation and the new entry price of seismic surveys unlocked by these technologies are already benefiting industries beyond oil and gas exploration. High trace density seismic has become accessible to industries playing a key role in the net-zero era, such as geothermal and carbon capture, utilization, and storage (CCUS), to which a good understanding of the subsurface geology is crucial to their success. We describe these benefits as observed during an ultra-high-density seismic survey acquired in June 2020 through a partnership between STRYDE, Explor, and Carbon Management Canada over the Containment and Monitoring Institute site. The smallest and lightest source and receiver equipment in the industry were used to achieve a trace density of 257 million traces/km2 over this test site dedicated to CCUS studies. We discuss the operational efficiency of the seismic acquisition, innovative techniques for data transfer and surveying, and preliminary results of the seismic data processing with a focus on the near-surface model and fast-track time migration.
Solid Dispersions of Gefitinib Prepared by Spray Drying with Improved Mucoadhesive and Drug Dissolution Properties
Authors: Mustafa Wesam W. , Fletcher John , Khoder Mouhamad , Alany Raid G.
Published: January 2022

Gefitinib is a tyrosine kinase inhibitor that is intended for oral administration yet suffers poor bioavailability along with undesirable side effects. To enhance its solubility and allow colon targeting, gefitinib (ZD) and blends of different ratios of polymers (ternary dispersion) were prepared in organic solution, and solid dispersions were generated employing the spray drying (SD) technique. The methylmethacrylate polymer Eudragit S 100 was incorporated for colon targeting; polyvinylpyrrolidone (PVP) and hydroxypropyl methyl cellulose (HPMC) were utilised to improve the solubility of ZD. SEM, DSC, XRPD, FT-IR, dissolution and cytotoxicity studies were undertaken to characterise and evaluate the developed formulations. SEM images revealed that the rod-shaped crystals of ZD were transformed into collapsed spheres with smaller particle size in the spray-dried particles. DSC, FTIR and XRPD studies showed that ZD loaded in the spray-dried dispersions was amorphous. ZD dissolution and release studies revealed that while a significant (P < 0.05) increase in the ZD dissolution and release was observed from HPMC-based solid dispersion at pH 7.2 (up to 95% in 15 h), practically no drug was released at pH 1.2 and pH 6.5. Furthermore, the HPMC-based solid dispersions displayed enhanced mucoadhesive properties compared with PVP-based ones. Interestingly, cell viability studies using the neutral red assay showed that PVP and HPMC-based solid dispersions had no additional inhibitory effect on Caco-2 cell line compared to the pure drug.
Imagining the Future(s) of Writing Studies through the Prism of Undergraduate Research
Authors: DelliCarpini Dominic
Published: January 2022

This article explores the future(s) of undergraduate research in writing studies through representative words of the undergraduates themselves. It reveals their social justice motives, as well as their desire to undertake research that can have real impact. It also questions whether inclusion in our disciplinary community supports—or blunts—those motives, highlighting the need to treat their work as an embodied act that may not be fully activated within traditional definitions of “contributions to knowledge.”
Guiding the Next Step
Authors: Golding Ian
Published: January 2022

This article examines the mentorship gap students face between the completion of a manuscript and its subsequent submission to a journal. Without continued faculty support, students often face unexpected hurdles as they enter the publication process. To alleviate these issues, the article discusses the value of extending undergraduate research mentorship.
The effect of introduction of routine immunization for rotavirus vaccine on paediatric admissions with diarrhoea and dehydration to Kenyan Hospitals: an interrupted time series study
Authors: Chelangat Daisy , Malla Lucas , Langat Reuben C. , Akech Samuel ,   Clinical Information Network Author Group
Published: January 2022

Background: Dehydration secondary to diarrhoea is a major cause of hospitalization and mortality in children aged less than five years. Most diarrhoea cases in childhood are caused by rotavirus, and routine introduction of rotavirus vaccine is expected to reduce the incidence and severity of dehydration secondary to diarrhoea in vaccinated infants. Previously, studies have examined changes in admissions with stools positive for rotavirus but this study reports on all admissions with dehydration secondary to diarrhoea regardless of stool rotavirus results. We aimed to assess the changes in all-cause severe diarrhoea and dehydration (DAD) admissions following the vaccine’s introduction.

Methods: We examined changes in admissions of all clinical cases of DAD before and after introduction of routine vaccination with rotavirus vaccine in July 2014 in Kenya. We use data from 13 public hospitals currently involved in a clinical network, the Clinical Information Network (CIN). Routinely collected data for children aged 2-36 months were examined. We used a segmented mixed effects model to assess changes in the burden of diarrhoea and dehydration after introduction of rotavirus vaccine. For sensitivity analysis, we examined trends for non-febrile admissions (surgical or burns).

Results: There were 17,708 patients classified as having both diarrhoea and dehydration. Average monthly admissions due to DAD for each hospital before vaccine introduction (July 2014) was 35 (standard deviation: ±22) and 17 (standard deviation: ±12) after vaccine introduction.  Segmented mixed effects regression model showed there was a 33% (95% CI, 30% to 38%) decrease in DAD admissions immediately after the vaccine was introduced to the Kenya immunization program in July 2014.  There was no change in admissions due to non-febrile admissions pre-and post-vaccine introduction. 

Conclusion: The rotavirus vaccine, after introduction into the Kenya routine immunization program resulted in reduction of all-cause admissions of diarrhoea and dehydration in children to public hospitals.
The Winding Paths of Russian Imperial Politics: On Die Geburt des russländischen Imperiums: Herrschaftskonzepte und -praktiken im 18. Jahrhundert by Ricarda Vulpius
Authors: Kosińska Urszula
Published: January 2022

The article discusses the book Die Geburt des russländischen Imperiums by Ricarda Vulpius, a publication that tracks the emergence of the conceptual background for governing the growing Russian Empire in the eighteenth century, when territorial gains rendered the country increasingly multinational, multi-faith and multicultural. In this paper, the book was treated as an inspiration for examining the relationship between the practices employed by Russia on newly acquired territories in the east and south of Asia, described by Vulpius in the book, and the Russian Empire’s policy towards Poland.
Poland as a periphery in Immanuel Wallerstein’s theory
Authors: Lewandowski Piotr
Published: January 2022

The article presents the issue of peripheries and its reference to Poland’s position in the world-system concept of Immanuel Wallerstein. The article discusses problems related to international security of Poland. It also presents the perception of Poland as a peripheral country and, on the basis of theoretical considerations, argues for the possibility of viewing Poland as a semi-peripheral country. Publication financed under the project implemented in the Research Grant Program of the Ministry of National Defence of the Republic of Poland.
Representações sociais da docência no Ensino Fundamental II: percepção do professor e identidade docente
Authors: De Sousa Adelson Pereira , Magalhães Verônica De Oliveira
Published: January 2022

Muitas inquietações emergiram acerca da representação social do professor a partir do contexto político econômico-social, em um momento do avanço da direita brasileira no plano do parlamento e da conquista do executivo federal. A polarização que marcou as eleições presidenciais de 2018 fez surgir uma espécie de “criminalização” de alguns setores sociais ou categorias profissionais por parte das novas forças políticas que surgiram das urnas, tais como artistas, jornalistas e professores. Esse “preconceito” ficou evidente nas redes sociais, sobretudo com a propagação de fake news que atribuíam aos professores um movimento de erotização de crianças e adolescentes através da prática docente nas escolas de educação básica. Em meio a essa onda conservadora de desqualificação do professor e da educação escolar, algumas reflexões sobre as políticas públicas educacionais devem ser retomadas, tais como: o sucateamento da escola de educação básica, a precariedade da formação docente e a política de valorização das atividades ligadas ao magistério. Este ensaio objetiva analisar como o professor do 6º ano do Ensino Fundamental se percebe enquanto sujeito nesse momento de polarização ideológica. Para buscar apontamentos sobre o problema levantado, realizou-se uma pesquisa qualitativa descritiva, onde se aplicou um questionário com questões discursivas e objetiva, que abordaram as percepções dos docentes sobre a figura do ser professor. Resultou-se ao analisar os dados a extrapolação do perfil do professor, da profissão docente, do prestígio social, do estímulo para jovens professores e do orgulho de ser professor. Considera-se que a partir dos discursos, a construção da identidade sofre com a diversidade de conceitos concebidos socialmente.
Versos e reversos de uma gestora escolar em tempos de ensino remoto
Authors: Muniz Joseane Lima
Published: January 2022

Diante do cenário pandêmico atual, a necessidade do ensino remoto fez com que os profissionais da educação se reinventassem. Nessa perspectiva, é necessário que os aprendizados adquiridos durante esse processo sejam registrados. Assim, a proposta deste manuscrito é relatar a experiência de uma coordenadora escolar à frente da gestão de uma escola da rede estadual do Ceará no ano de 2020. O trabalho baseou-se em uma pesquisa bibliográfica atrelada ao relato da prática da própria autora, o qual apresenta as dificuldades, os desafios e as superações, envolvendo os diferentes processos que são realidades na educação como a avaliação, o acompanhamento pedagógico e o desenvolvimento de projetos que acontecem no cotidiano escolar, e como tudo isso tornou-se possível acontecer fora dos muros da escola. De acordo com o relato foi possível perceber que a escola, já tão importante em tempos “normais”, nesse momento de distanciamento foi ainda mais necessária, rompendo espaços físicos e estreitando vínculos.
Da angústia à felicidade: caminhos tecnológicos de professores na pandemia
Authors: Arruda Heloisa Paes de Barros , Hessel Ana Maria Di Grado
Published: January 2022

O presente artigo tem como objetivo analisar os sentimentos e suas situações indutoras a partir da experiência de cinco professores do ensino fundamental da Rede Municipal de São Paulo com as aulas remotas. A pesquisa qualitativa discute as situações pedagógicas de que mais gostaram e aquelas de que menos gostaram no contexto da pandemia (Covid-19) de aulas mediadas pelas Tecnologias Digitais da Informação e Comunicação (TDIC). Os dados foram coletados em agosto de 2020 com questionário formado por perguntas abertas e discutidos à luz da teoria de Henri Wallon por meio da análise de conteúdo, que mostraram a amplitude de sentimentos positivos e negativos relacionados à situação inusitada das aulas remotas. Sentimentos variados foram identificados: ansiedade e angústia pela situação nova e imediata das aulas mediadas pelas TDIC, a felicidade e satisfação de docentes pela participação dos alunos na aula síncrona, a alegria de alunos, que compreenderam o conteúdo. Alunos e professores, pessoas que devem ser observadas em sua integralidade, manifestam suas necessidades afetivas, cognitivas e motoras durante o processo de ensino-aprendizagem. Compreendendo essas necessidades, poderemos atendê-las e proporcionar um melhor aproveitamento nas situações pedagógicas.
Esquete online educação além da distância: compartilhando experiências das aulas virtuais de teatro no IFCE
Authors: Aquino Júnior José Tomaz de , Pinho Maria Jaene Aguiar , Dias Rayssa Torres
Published: January 2022

O esquete online Educação além da distância teve sua estreia no dia 11 de junho de 2018 no lançamento do livro EaD no Estado do Ceará: história, memória e experiências formativas. O trabalho objetivou refletir sobre a atual situação do professor e do estudante, no ensino remoto, compartilhando experiências e desafios, revelando o cotidiano da sala de aula virtual, com as falhas tecnológicas, as angustias e aflições desses atores/atrizes da educação. Teve a colaboração dos discentes do ensino integrado do Instituto Federal de Educação, por meio dos vídeos produzidos nas aulas de Arte/Teatro. A cena virtual repensa o fazer pedagógico por meio de um diálogo que reforça a relação ensino-aprendizagem colocando o/a discente como protagonista nesse processo.
A COISA JULGADA DE QUESTÃO PREJUDICIAL NO CPC15 E O PRINCÍPIO DISPOSITIVO
Authors: Steffler Luan Eduardo , Oliveira Rafael Niebuhr Maia de
Published: January 2022

Trata-se de pesquisa qualitativa exploratória, de procedimento monográfico, de abordagem dedutiva, objetivando analisar as modificações implementadas pelo CPC/15 nos limites objetivos da coisa julgada material, mais especificamente quanto a possibilidade de sua extensão as questões prejudiciais, independentemente de ação declaratória incidental, com o escopo de perquirir se esta mudança representaria ofensa ao princípio dispositivo. Com base nas fontes adotadas e a partir de uma análise história do instituto e com espeque em semelhante instrumento processual estrangeiro  do colateral estoppel, pode-se afirmar que a legislação atual tomou as precauções necessárias para evitar que as notadas vantagens advindas da maior celeridade, eficiência e redução na possibilidade de decisões logicamente contraditórias não fossem conquistadas as custas dos princípios democráticos do processo, especialmente no que tange a necessidade de contraditório prévio e efetivo como condicionante desta possibilidade, pelo que não se verifica ofensa ao princípio dispositivo.
ANÁLISE DA AUTOCOMPOSIÇÃO E DA AÇÃO COLETIVA COMO CAUSAS DE SUSPENSÃO E DE INTERRUPÇÃO DA PRESCRIÇÃO PARA AÇÕES INDIVIDUAIS NO DESASTRE DO RIO DOCE
Authors: Zaneti Jr. Hermes , Schimidt Rafaella Boone , Machado Cristina De Freitas Caiado
Published: January 2022

O artigo possui como escopo a demonstração da inocorrência da prescrição das pretensões individuais indenizatórias no Desastre do Rio Doce, em razão da ação coletiva e da autocomposição como causas, respectivamente, de interrupção e de suspensão do prazo prescricional para ações individuais advindas desse desastre, ocorrido devido ao rompimento da barragem de Fundão, em Mariana. A conduta das empresas, que gerou enorme insegurança jurídica, é destacada. Ao final, salienta-se como o caso em estudo tornou-se importante precedente persuasivo para futuros casos análogos, e também a existência de atuais projetos de lei pertinentes ao regime da prescrição na ação coletiva.
PROCESSOS ESTRUTURAIS E DIÁLOGOS INSTITUCIONAIS NO SUPREMO TRIBUNAL FEDERAL: UMA ANÁLISE DOS ARGUMENTOS JUDICIAIS NA ADPF 347
Authors: França Eduarda Peixoto da Cunha
Published: January 2022

A declaração do Estado de Coisas Inconstitucional no sistema carcerário brasileiro pelo Supremo tribunal Federal, foi amplamente celebrada entre os acadêmicos do Direito Constitucional e do Direito Processual Civil, tendo em vista abertura do Tribunal à apreciação dos chamados “litígios estruturais” e aos diálogos institucionais. Apesar disso, anos após a sua declaração, pouco ou nada mudou nas condições degradantes do sistema carcerário do país.  O presente artigo busca investigar as possíveis razões que contribuiram para a manutenção do status quo violador de direitos, dando enfoque no estudo da (in)disponibilidade de cooperação interinstitucional após a concessão parcial da liminar. Para tanto, o trabalho será dividido em três partes, nas quais serão estudadas, respectivamente: a ideia de ativismo dialógico enquanto alternativa ao ativismo solipsista e à autocontenção judicial; duas teorias normativas que direcionam a postura jurisdicional frente à judicialização de questões estruturais; e, por fim, a ADPF 347. A pesquisa é de cunho bibliográfico-documental com análise qualitativa de caso.
TUTELAS PROVISÓRIAS E A EFETIVAÇÃO DO PROCESSO DE TOMADA DE DECISÃO APOIADA NA LEGISLAÇÃO BRASILEIRA
Authors: Bellé Cathiani Mara , Dammski Luiz Paulo
Published: January 2022

A Lei 13.146/2015 trouxe inovações e avanços na proteção à pessoa com deficiência, especialmente ao introduzir o procedimento da Tomada de Decisão Apoiada (TDA). Tal inovação, todavia, não veio acompanhada de um aparato processual hábil a sua efetivação de forma célere e efetiva. Assim, o presente artigo pretende investigar a possibilidade de extensão da disciplina aplicável às tutelas provisórias ao procedimento da TDA. Pautada em análise bibliográfica e no direito comparado, a pesquisa circunscreve um método dedutivo na ponderação de qual tutela provisória compreende as exigências de seguridade dos direitos das pessoas com deficiência.
A NECESSIDADE DE CONFISSÃO COMO REQUISITO PARA O ACORDO DE NÃO PERSECUÇÃO PENAL E AS REPERCUSSÕES PRODUZIDAS NO PROCESSO PENAL E NAS DEMAIS ESFERAS DO DIREITO
Authors: Daguer Beatriz , Soares Rafael Junior , Fidelis Pereira Biagi Talita Cristina
Published: January 2022

O presente ensaio tem por escopo discutir as modificações legislativas trazidas pela Lei nº 13.964/2019, em especial o acordo de não persecução penal, o qual figura como ampliador da justiça negocial no Brasil, tendo como um dos seus requisitos a necessidade de confissão formal e circunstanciada para concessão do benefício pelo Estado. Assim, o investigado que aceitar o acordo deve elaborar termo de confissão incluindo todas as circunstâncias em que ocorreu o suposto ato ilícito. No entanto, algumas questões devem ser examinadas de forma mais cuidadosa, em especial a exigência de confissão e os possíveis reflexos ocasionados no próprio processo penal e também nas demais esferas jurídicas. Deste modo, valendo-se de metodologia hipotético-dedutiva e de ampla revisão bibliográfica, bem como analisando possíveis situações legais e suas repercussões, buscar-se-á demonstrar os aspectos positivos e negativos desta modalidade. Além disso, serão examinadas as prováveis consequências advindas da confissão nos termos em que foi inserida no diploma processual penal brasileiro.
O DILEMA DA PRESTAÇÃO DE CONTAS ALIMENTAR NA JURISPRUDÊNCIA DO STJ À LUZ DO CPC/2015 E DO DIREITO DA PERSONALIDADE
Authors: Medina Valéria Julião Silva , Soares Marcelo Negri
Published: January 2022

O artigo tem como objetivo analisar no âmbito do sistema jurídico brasileiro a viabilidade do ajuizamento da ação de prestação de contas de alimentos no direito de família, considerando que há uma jurisprudência pacificada no STJ acerca de sua impossibilidade e um precedente recente a admitindo, prolatado em uma de suas Turmas. Através do método indutivo, mediante análise de casos julgados foram tecidos fundamentos que justificam a manutenção da controvérsia na Corte, e a necessidade de uma solução, o mais breve possível, em especial à luz do direito da personalidade das partes envolvidas e da segurança jurídica.
Standards probatórios no mandado de segurança – critérios para apreciação da verdade
Authors: Lemos Rafael Diogo , Augusto de Oliveira Júnior Vicente De Paulo
Published: January 2022

Neste trabalho, será analisada a importância dos standards probatórios e sua contribuição com a racionalidade e objetividade das decisões judiciais. Serão verificados critérios para formação de um standard de prova e a necessária contextualização deste critério com aspectos metodológicos, epistemológicos, jurídicos e políticos. Buscar-se-á, de modo mais objetivo, analisar os standards exigidos no mandado de segurança, dada sua peculiaridade procedimental e probatória. Debate-se, também, os critérios e padrões na busca pela verdade no processo e em que ponto fatores não-epistemológicos” influenciam na busca pela verdade no processo.
O CABIMENTO DO INCIDENTE DE RESOLUÇÃO DE DEMANDAS REPETITIVAS NO ÂMBITO DOS JUIZADOS ESPECIAIS ESTADUAIS
Authors: Carvalho Ciro Antonio das Mercês
Published: January 2022

O trabalho explora o cabimento do Incidente de Resolução de Demandas Repetitivas (IRDR), a partir da análise de um caso concreto em diálogo com fontes normativas e doutrinárias do ramo do direito processual civil. Quanto aos procedimentos aplicados, trata-se de uma pesquisa teórica com caráter majoritariamente qualitativo. O trabalho é prioritariamente bibliográfico. Por meio de uma concatenação dos dados de jurisprudências, regimentos internos de tribunais de justiça e da lei n. 9.099/95, que regulamenta os juizados especiais cíveis, imergiu-se teórica, crítica e analiticamente na aplicabilidade do IRDR na instância recursal de causas oriundas de varas especiais estaduais. Buscou-se despertar a reflexão quanto a ausência de regulamentação normativa do IRDR nos juizados especiais estaduais a partir de um caso concreto com suas implicações e semelhanças com outros processos no Judiciário brasileiro.
A GRATUIDADE DA JUSTIÇA PARA MENOR DE IDADE EM AÇÃO DE ALIMENTOS
Authors: Abreu Barroso Lucas , Rodrigues Pereira Assis Sara
Published: January 2022

Este artigo se propõe a abordar a gratuidade da justiça para menor de idade em ação de alimentos, pois a investigação científica do qual provém indicou a necessidade de adequação dos critérios para sua concessão neste tipo de demanda judicial, a fim de não se confundir a situação financeira do beneficiário (crianças e adolescentes) com a de seu/sua representante/assistente legal. Vinculado à linha crítico-metodológica, este artigo busca repensar os institutos jurídicos de maneira atual e apresentar soluções para os casos concretos, bem como, ao assumir a vertente jurídico-dogmática, discutir as proposições normativas aplicáveis com a atenção voltada para a sociedade e seus conflitos, de modo a permitir que o direito alcance efetividade social.
O RECONHECIMENTO CRIMINAL DE PESSOA A PARTIR DE VÍDEO DE VIGILÂNCIA
Authors: Guedes Clarissa Diniz , Fardim Giulia Alves , Riccio Vicente
Published: January 2022

Este artigo questiona a existência, no Brasil, de procedimento para a realização do reconhecimento criminal de pessoa a partir de vídeo de vigilância. A hipótese é de que a regulação existente não compreende as particularidades do vídeo, fazendo-se necessários aportes epistêmicos para um procedimento específico, confiável e válido. A metodologia compreende análise da legislação, revisão de literatura e pesquisa empírica qualitativa em acórdãos criminais a fim de examinar as particularidades da prática criminal. Os resultados demostram a inexistência de uniformidade procedimental e a configuração de uma valoração judicial que trata a imagem como retrato fiel da realidade
NOVAS TENDÊNCIAS NA INVESTIGAÇÃO DE CRIMES COMPLEXOS EM UM CONTEXTO EUROPEU GLOBALIZADO
Authors: Mata Federico Bueno de
Published: January 2022

O presente artigo objetiva relacionar o fenômeno dos crimes cibernéticos e os seus desafios em relação ao Direito Processual. Realizar-se-á, nesse contexto, uma análise (i) acerca dos meios de prova mais adequados a esse tipo de crime, bem como (ii) da forma como cada país pode lidar com o assunto nos limites e extensões de sua jurisdição, de modo a realizar investigações que produzam resultados positivos e válidos
ASPECTOS RELEVANTES DAS TUTELAS PROVISÓRIAS DE URGÊNCIA NOS SISTEMAS PROCESSUAIS BRASILEIRO E PORTUGUÊS
Authors: Mazini Paulo Guilherme
Published: January 2022

A tutela provisória ainda se apresenta como um dos temas mais discutidos no processo civil, especialmente após a vigência do novo Código de Processo Civil brasileiro, que passou a ser aplicado no ano de 2016. Algumas mudanças relevantes foram propostas com o novo diploma legal, as quais tiveram por objetivo, sobretudo, a unificação do regime das tutelas de urgência e a inclusão de uma nova modalidade de estabilização das decisões a ser observada nas tutelas satisfativas ajuizadas em caráter antecedente. Em Portugal, o Código de Processo Civil em vigor desde o ano de 2013, apesar de suas distinções e da convivência do regime de cautelares típicas e atípicas, previu um modelo interessante de resolução sumária de conflitos denominado inversão do contencioso, além de apresentar uma modalidade de tutela autoexauriente com nítida aproximação das tutelas inibitórias do direito brasileiro. Pretende-se assim, com o presente artigo, desenvolver, sob a perspectiva do direito comparado, um estudo com a finalidade de analisar os principais pontos de vista a respeito das tutelas sumárias nos sistemas brasileiro e português.
O PRINCÍPIO DA IMEDIAÇÃO NO PROCESSO CIVIL EM PORTUGAL EM TEMPOS DE PANDEMIA: A REALIZAÇÃO DAS AUDIÊNCIAS POR VIDEOCONFERÊNCIA
Authors: Faria Rita Lynce de
Published: January 2022

O presente artigo visa averiguar de que forma o regime de realização de audiências por videoconferências, instituído pela Lei 1-A/2020 de 19 de Março, afetou o princípio da imediação. Para tanto, será trabalhado o sentido e significado do princípio da imediação, se exporá a forma de realização das audiências de julgamento durante o período da pandemia e, por fim, será avaliado se houve ou não efetiva violação do princípio da imediação.
Impact of non-medical prescribing
Authors: Robertson Deborah
Published: January 2022

Deborah Robertson provides an overview of recently published articles that may be of interest to non-medical prescribers. Should you wish to look at any of the papers in more detail, a full reference is provided
Lead Identification for Severe Acute Respiratory Syndrome Coronavirus-2 Spike D614G Variant of COVID-19: A virtual Screening Process
Authors: Kullappan Malathi , M Ambrose Jenifer , Mohan Surapaneni Krishna
Published: January 2022

COVID-19, a pandemic disease caused by single-stranded RNA virus Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). The structural spike (S) protein of SARS-CoV-2 plays a vital role in host cell entry, where the Angiotensin-Converting Enzyme-2 (ACE2) receptor of the human cell binds to the Receptor Binding Domain (RBD) region of the S1 domain and makes cell entry. The binding affinity of SARS-CoV-2-ACE2 is tenfold higher than the SARS-CoV-1-ACE2. Recent studies expose that the SARS-CoV-2 S D614G variant is highly infectious than D614 protein, also the D614G variant is highly stable than D614. So far, there is no effective viral-specific regimen for COVID-19. To overcome such problems, in our study, we have utilized the ZINC database to screen potent leads against the highly transmitting SARS-CoV-2 spike D614G protein, through a virtual screening procedure. We have applied three computational tools iGEMDOCK server, AutoDock version 4.2.6 and admetSAR to get active leads. The ZINC000150588351 (Elbasvir), ZINC000064540179 (Sofosbuvir analogue) and ZINC000137700912 (Sofosbuvir analogue) molecules have a greater binding affinity with the high binding energies of -8.22 kcal/mol, -8.13 kcal/mol and -7.64 kcal/mol respectively. The molecules ZINC000064540179 and ZINC000137700912 have high binding energy than their core molecule Sofosbuvir (ZINC100074252) of -4.06 kcal/mol. The ADMET prediction of these molecules reveals satisfactory human intestinal absorption and non-mutagenic property. Our results deliver valuable contributions to the design of inhibitors against COVID-19.