bluuebunny/crossref_metadata_2025 huggingface dataset:
Embracing liberatory alienation:AI will end us, but not in the way you may think
Authors: Sidorkin Alexander M.
Published: July 2024

This paper introduces the concept of "liberatory alienation" to explore the complex relationship between technological
advancement, particularly artificial intelligence (AI), and human essence. Building upon and critiquing Marx's theory of
alienation, we argue that the externalization of human abilities through technology, while potentially disorienting, can
ultimately lead to societal liberation and a redefined conception of humanity. The paper examines how AI and automation
are reshaping our understanding of labor, skills, and human nature, challenging traditional notions of what it means to be
human.

We propose that as AI increasingly takes over both manual and routine cognitive tasks, humans are liberated to focus on
uniquely human qualities such as creativity, agency, and the capacity for joy. This transformation is likened to an
evolutionary process, where humans shed layers of false humanity tied to productive labor, revealing a more authentic
core. The implications of this shift for education are discussed, advocating for a fundamental reassessment of educational
priorities to cultivate these essential human qualities.

The paper also addresses potential challenges, including the environmental impact of AI development and the need for
human control over AI systems. By reframing alienation as a potentially liberating force, this work contributes to ongoing
debates about the future of work, human identity, and the role of technology in society, offering a nuanced perspective on
how we might navigate the profound changes brought about by AI and automation.
Readability of Patient-Facing Information of Antibiotics Used in the WHO Short 6-Month and 9-Month All Oral Treatment for Drug-Resistant Tuberculosis
Authors: Moore John E. , Millar Beverley C.
Published: July 2024

Objectives

Readability of patient-facing information of oral antibiotics detailed in the WHO all oral short (6 months, 9 months) has not been described to date. The aim of this study was therefore to examine (i) how readable patient-facing TB antibiotic information is compared to readability reference standards and (ii) if there are differences in readability between high-incidence countries versus low-incidence countries.

Methods

Ten antibiotics, including bedaquiline, clofazimine, ethambutol, ethionamide, isoniazid, levofloxacin, linezolid, moxifloxacin, pretomanid, pyrazinamide, were investigated. TB antibiotic information sources were examined, consisting of 85 Patient Information Leaflets (PILs) and 40 antibiotic web resouces. Of these 85 PILs, 72 were taken from the National Medicines Regulator from six countries (3 TB high-incidence [Rwanda, Malaysia, South Africa] + 3 TB low-incidence [UK, Ireland, Malta] countries). Readability data was grouped into three categories, including (i) high TB-incidence countries (n = 33 information sources), (ii) low TB-incidence countries (n = 39 information sources) and (iii) web information (n = 53). Readability was calculated using Readable software, to obtain four readability scores [(i) Flesch Reading Ease (FRE), (ii) Flesch-Kincaid Grade Level (FKGL), (iii) Gunning Fog Index and (iv) SMOG Index], as well as two text metrics [words/sentence, syllables/word].

Results

Mean readability scores of patient-facing TB antibiotic information for FRE and FKGL, were 47.4 ± 12.6 (sd) (target ≥ 60) and 9.2 ± 2.0 (target ≤ 8.0), respectively. There was no significant difference in readability between low incidence countries and web resources, but there was significantly poorer readability associated with PILs from high incidence countries versus low incidence countries (FRE; p = 0.0056: FKGL; p = 0.0095).

Conclusions

Readability of TB antibiotic PILs is poor. Improving readability of PILs should be an important objective when preparing patient-facing written materials, thereby improving patient health/treatment literacy.
Longitudinal evaluation of polyneuropathy in Parkinson’s disease
Authors: Kwon Eun Hae , Bieber Antonia , Schülken Paula , Müller Katharina , Kühn Eva , Averdunk Paulina , Kools Saskia , Hilker Lovis , Kirchgässler András , Ebner Lea , Ortmann Louisa , Basner Louisa , Steininger Julia , Kleinz Teresa , Motte Jeremias , Fisse Anna Lena , Schneider-Gold Christiane , Gold Ralf , Scherbaum Raphael , Muhlack Siegfried , Tönges Lars , Pitarokoili Kalliopi
Published: July 2024

Background

Increasing evidence indicates a higher prevalence of polyneuropathy (PNP) in Parkinson’s disease (PD). However, the involvement of large fiber neuropathy in PD still remains poorly understood. Given the lack of longitudinal data, we investigated the course of PNP associated with PD.

Methods

In total, 41 PD patients underwent comprehensive clinical evaluation including motor and non-motor assessments as well as nerve conduction studies at baseline and at 2 years of follow-up. The definition of PNP was based on electrophysiological standard criteria. Common causes of PNP were excluded.

Results

At baseline, PNP was diagnosed in 65.85% of PD patients via electroneurography. Patients with PNP presented with higher age (p = 0.019) and PD motor symptom severity (UPDRS III; p < 0.001). Over the course of 2 years, PNP deteriorated in 21.95% of cases, and 26.83% remained without PNP. Deterioration of nerve amplitude was most prevalent in the median sensory nerve affecting 57.58% of all PD cases with an overall reduction of median sensory nerve amplitude of 45.0%. With regard to PD phenotype, PNP progression was observed in 33.33% of the tremor dominant and 23.81% of the postural instability/gait difficulties subtype. Decrease of sural nerve amplitude correlated with lower quality of life (PDQ-39, p = 0.037) and worse cognitive status at baseline (MoCA, p = 0.042).

Conclusion

The study confirms the high PNP rate in PD, and demonstrates a significant electrophysiological progression also involving nerves of the upper extremities. Longitudinal studies with larger cohorts are urgently needed and should elucidate the link between PD and PNP with the underlying pathomechanisms.
KIS, a target of SOX4, regulates the ID1-mediated enhancement of β-catenin to facilitate lung adenocarcinoma cell proliferation and metastasis
Authors: Chang Jing-Xia , Zhang Meng , Lou Li-Li , Chu He-Ying , Wang Hua-Qi
Published: July 2024

Purpose

Kinase interacting with stathmin (KIS) is a serine/threonine kinase involved in RNA processing and protein phosphorylation. Increasing evidence has suggested its involvement in cancer progression. The aim of this study was to investigate the role of KIS in the development of lung adenocarcinoma (LUAD). Dual luciferase assay was used to explore the relationship between KIS and SOX4, and its effect on ID1/β-catenin pathway.

Methods

Real-time qPCR and western blot were used to assess the levels of KIS and other factors. Cell proliferation, migration, and invasion were monitored, and xenograft animal model were established to investigate the biological functions of KIS in vitro and in vivo.

Results

In the present study, KIS was found to be highly expressed in LUAD tissues and cell lines. KIS accelerated the proliferative, migratory and invasive abilities of LUAD cells in vitro, and promoted the growth of LUAD in a mouse tumor xenograft model in vivo. Mechanistically, KIS activated the β-catenin signaling pathway by modulating the inhibitor of DNA binding 1 (ID1) and was transcriptionally regulated by SOX4 in LUAD cells.

Conclusion

KIS, a target of SOX4, regulates the ID1-mediated enhancement of β-catenin to facilitate LUAD cell invasion and metastasis.
MASCC/ISOO Clinical Practice Statement: The risk of secondary oral cancer following hematopoietic cell transplantation
Authors: Raber-Durlacher Judith E. , Treister Nathaniel S. , Zadik Yehuda , Dean David R. , Miranda-Silva Wanessa , Fregnani Eduardo R. , Epstein Joel B. , Elad Sharon
Published: July 2024

Purpose

A MASCC/ISOO Clinical Practice Statement (CPS) is aimed at generating a concise tool for clinicians that concentrates practical information needed for the management of oral complications of cancer patients. This CPS is focused on the risk of secondary oral cancer following hematopoietic cell transplantation (HCT).

Methods

This CPS was developed based on critical evaluation of the literature followed by a structured discussion of a group of leading experts, members of the Oral Care Study Group of MASCC/ISOO. The information is presented in the form of succinct bullets to generate a short manual about the best standard of care.

Results

Studies described a 7–16-fold higher risk of secondary oral cancer (mainly squamous cell carcinoma) in allogeneic HCT (alloHCT) recipients, particularly in those who developed chronic graft versus host disease (cGVHD). Risk increases over time and is influenced by several risk factors. In autologous HCT, oral cancer risk seemed only slightly elevated.

Conclusion

Clinicians should be aware of the higher oral cancer risk in alloHCT survivors, and emphasize the importance of lifelong oral cancer surveillance (at least every 6–12 months) and avoiding cancer promoting lifestyle factors in an empathic way, particularly of those with (a history of) cGVHD. Post-HCT for Fanconi anemia or dyskeratosis congenita, education and rigorous follow-up is even more crucial. In case of suspected oral lesions in the presence of oral mucosal cGVHD, a GVHD intervention may facilitate diagnosis. Suspected lesions should be biopsied. More research is needed on the role of HPV in oral cancer post-HCT.
Bone marrow aspirate and bone marrow aspirate concentrate: Does the literature support use in long-bone nonunion and provide new insights into mechanism of action?
Authors: Moyal Andrew J. , Li Austin W. , Adelstein Jeremy M. , Moon Tyler J. , Napora Joshua K.
Published: July 2024

Purpose

To assess the use of bone marrow aspirate (BM) and bone marrow aspirate concentrate (BMAC) in the treatment of long-bone nonunion and to understand mechanism of action.

Methods

A systematic review of PubMed and EBSCOHost was completed to identify studies that investigated the use of BM or BMAC for the diagnosis of delayed union and/or nonunion of long-bone fractures. Studies of isolated bone marrow-mesenchymal stem cells (BM-MSCs) and use in non-long-bone fractures were excluded. Statistical analysis was confounded by heterogeneous fracture fixation methods, treatment history, and scaffold use.

Results

Our initial search yielded 430 publications, which was screened down to 25 studies. Successful treatment in aseptic nonunion was reported at 79–100% (BM) and 50–100% (BMAC). Septic nonunion rates were slightly better at 73–100% (BM) and 83.3–100% (BMAC). 18/24 studies report union rates > 80%. One study reports successful treatment of septic nonunion with BMAC and no antibiotics. A separate study reported a significant reduction in autograft reinfection rate when combined with BMAC (P = 0.009). Major adverse events include two deep infections at injection site and one case of heterotopic ossification. Most studies note transient mild donor site discomfort and potential injection site discomfort attributed to needle size.

Conclusion

The current literature pertaining to use of BM/BMAC for nonunion is extremely heterogeneous in terms of patient population and concomitant treatment modalities. While results are promising for use of BM/BMAC with other gold standard treatment methodologies, the literature requires additional Level I data to clarify the impact of role BM/BMAC in treating nonunion when used alone and in combination with other modalities.

Level of evidence

Level III.
Thermo-mechanical investigation of a friction oscillator under high-frequency excitation
Authors: Keller Simon , Fidlin Alexander
Published: July 2024

The frictional behavior, temperature evolution, and system dynamics in tribological systems are closely coupled. However, in many cases, at least one of the mentioned phenomena is neglected or not modeled consistently. This paper presents a model of a thermo-mechanically coupled oscillator, where the reduction of friction force due to high-frequency excitation is analyzed. The oscillator’s equation of motion, the impulse balance, and the heat equation for the thermo-mechanical continuum are evaluated so that a set of nonlinear equations describes the coupled system. Using specific mathematical procedures like Laplace-transformation and a particular transformation ansatz for integral equations, the system can be transformed into a set of ordinary differential equations, enabling efficient simulation. Based on this equation set, an averaging method is applied to eliminate the fast time scale of the mechanical oscillation due to high-frequency excitation so that only the averaged influence of the motion goes into the heat evolution. This procedure leads to concise expressions to determine the stationary state of the system, and the quantities of interest can be calculated conveniently. These equations yield parameter combinations where the friction force can be reduced due to the high-frequency excitation, even though thermal expansion is considered. However, there are also parameter regions where the excitation yields a significantly larger friction force.
Investigating the relationship between physical cognitive tasks and a social cognitive task in a wild bird
Authors: Blackburn Grace , Ashton Benjamin J. , Thornton Alex , Hunter Holly , Woodiss-Field Sarah , Ridley Amanda R.
Published: July 2024

Despite considerable research into the structure of cognition in non-human animal species, there is still much debate as to whether animal cognition is organised as a series of discrete domains or an overarching general cognitive factor. In humans, the existence of general intelligence is widely accepted, but less work has been undertaken in animal psychometrics to address this question. The relatively few studies on non-primate animal species that do investigate the structure of cognition rarely include tasks assessing social cognition and focus instead on physical cognitive tasks. In this study, we tested 36 wild Western Australian magpies (Gymnorhina tibicen dorsalis) on a battery of three physical (associative learning, spatial memory, and numerical assessment) and one social (observational spatial memory) cognitive task, to investigate if cognition in this species fits a general cognitive factor model, or instead one of separate physical and social cognitive domains. A principal component analysis (PCA) identified two principal components with eigenvalues exceeding 1; a first component onto which all three physical tasks loaded strongly and positively, and a second component onto which only the social task (observational spatial memory) loaded strongly and positively. These findings provide tentative evidence for separate physical and social cognitive domains in this species, and highlight the importance of including tasks assessing both social and physical cognition in cognitive test batteries.
Thermal insulation does not hamper assessment of injuries in trauma CT scans
Authors: Sanak Tomasz , Skowronek Aleksandra , Mendrala Konrad , Darocha Tomasz , Liszka Grzegorz , Chrzan Robert , Woźniak Krzysztof Jerzy , Staskiewicz Grzegorz , Podsiadło Paweł
Published: July 2024

Purpose

The use of thermal insulations reduces the risk of hypothermia, therefore decreases the risk of death in trauma victims. The aim of the study was to assess whether thermal insulations cause artifacts, which may hinder the diagnosis of injuries, and how the used thermo-systems alter the radiation dose in polytrauma computed tomography.

Methods

Computed tomography scans were made using the road accident victim body wrapped consecutively with 7 different covers. 14 injury areas were listed and evaluated by 22 radiologists. The radiation dose was measured using a dosimeter placed on the victim in the abdominal area.

Results

No significant artifacts in any of the tested covers were observed. The presence of few minor artifacts did not hinder the assessment of injuries. Certain materials increased (up to 19,1%) and some decreased (up to -30,3%) the absorbed radiation dose.

Conclusions

Thermal insulation systems tested in this study do not cause significant artifacts hindering assessment of injuries in CT scans. Concern for artifacts and increased radiation dose should not be a reason to remove patients’ thermal insulation during performing trauma CT-scanning.
Multiple craniotomies in patients with brain metastases: a two-center, propensity score-matched study
Authors: Padevit Luis , Zeitlberger Anna Maria , Maldaner Nicolai , Sarnthein Johannes , Bozinov Oliver , Regli Luca , Neidert Marian Christoph , Serra Carlo , Voglis Stefanos
Published: July 2024

The current study addresses the question of whether the resection of more than one BM by multiple craniotomies within the same operation is associated with more adverse events (AEs) and worse functional outcome compared to cases in which only one BM was resected. All patients who underwent more than one craniotomy for resection of multiple BM at two Swiss tertiary neurosurgical care centers were included. Any AEs, functional outcome, and overall survival (OS) were analyzed after 1:1 propensity score matching with patients who underwent removal of a single BM only. A total of 94 patients were included in the final study cohort (47 of whom underwent multiple craniotomies). There was no significant difference in the incidence of AEs between the single and the multiple craniotomy group (n = 2 (4.3%) vs. n = 4 (8.5%), p = .7). Change in modified Rankin Scale (mRS) and Karnofsky Performance Status (KPS) at discharge demonstrated that slightly more single craniotomy patients improved in mRS, while the proportion of patients who worsened in mRS (16.3 vs. 16.7%) and KPS (13.6 vs. 15.2%) was similar in both groups (p = .42 for mRS and p = .92 for KPS). Survival analysis showed no significant differences in OS between patients with single and multiple craniotomies (p = .18). Resection of multiple BM with more than one craniotomy may be considered a safe option without increased AEs or worse functional outcome.
Emerging insights into the pathogenesis and therapeutic strategies for vascular endothelial injury-associated diseases: focus on mitochondrial dysfunction
Authors: Pang Boxian , Dong Guangtong , Pang Tieliang , Sun Xinyao , Liu Xin , Nie Yifeng , Chang Xing
Published: July 2024

As a vital component of blood vessels, endothelial cells play a key role in maintaining overall physiological function by residing between circulating blood and semi-solid tissue. Various stress stimuli can induce endothelial injury, leading to the onset of corresponding diseases in the body. In recent years, the importance of mitochondria in vascular endothelial injury has become increasingly apparent. Mitochondria, as the primary site of cellular aerobic respiration and the organelle for “energy information transfer,” can detect endothelial cell damage by integrating and receiving various external stress signals. The generation of reactive oxygen species (ROS) and mitochondrial dysfunction often determine the evolution of endothelial cell injury towards necrosis or apoptosis. Therefore, mitochondria are closely associated with endothelial cell function, helping to determine the progression of clinical diseases. This article comprehensively reviews the interconnection and pathogenesis of mitochondrial-induced vascular endothelial cell injury in cardiovascular diseases, renal diseases, pulmonary-related diseases, cerebrovascular diseases, and microvascular diseases associated with diabetes. Corresponding therapeutic approaches are also provided. Additionally, strategies for using clinical drugs to treat vascular endothelial injury-based diseases are discussed, aiming to offer new insights and treatment options for the clinical diagnosis of related vascular injuries.
AI’s effect on innovation capacity in the context of industry 5.0: a scoping review
Authors: Bécue Adrien , Gama Joao , Brito Pedro Quelhas
Published: July 2024

The classic literature about innovation conveys innovation strategy the leading and starting role to generate business growth due to technology development and more effective managerial practices. The advent of Artificial Intelligence (AI) however reverts this paradigm in the context of Industry 5.0. The focus is moving from “how innovation fosters AI” to “how AI fosters innovation”. Therefore, our research question can be stated as follows: What factors influence the effect of AI on Innovation Capacity in the context of Industry 5.0? To address this question we conduct a scoping review of a vast body of literature spanning engineering, human sciences, and management science. We conduct a keyword-based literature search completed by bibliographic analysis, then classify the resulting 333 works into 3 classes and 15 clusters which we critically analyze. We extract 3 hypotheses setting associations between 4 factors: company age, AI maturity, manufacturing strategy, and innovation capacity. The review uncovers several debates and research gaps left unsolved by the existing literature. In particular, it raises the debate whether the Industry5.0 promise can be achieved while Artificial General Intelligence (AGI) remains out of reach. It explores diverging possible futures driven toward social manufacturing or mass customization. Finally, it discusses alternative AI policies and their incidence on open and internal innovation. We conclude that the effect of AI on innovation capacity can be synergic, deceptive, or substitutive depending on the alignment of the uncovered factors. Moreover, we identify a set of 12 indicators enabling us to measure these factors to predict AI’s effect on innovation capacity. These findings provide researchers with a new understanding of the interplay between artificial intelligence and human intelligence. They provide practitioners with decision metrics for a successful transition to Industry 5.0.
Non-compliance as a determinant of constitutional change? A comparative study
Authors: Schnelle Tim
Published: July 2024

It has often been claimed that if constitutions are not complied with, they will be changed. Because an ineffective constitutional contract is a bad contract, a lack of enforcement should induce constitutional reform. This paper empirically tests this conjecture based on a dataset of 170 countries from 1950 to 2018. The results indicate that the size of the de jure/de facto gap has no effect on the likelihood of constitutional change as such. However, after differentiating between amendments and replacements as distinct modes of constitutional reform, the results imply that non-compliance robustly increases the probability of constitutional replacement only. This relationship is primarily driven by an implementation gap regarding political and civil rights. Expected moderating effects of interpersonal trust and civil society organizations as catalysts for successful civil reform movements cannot be empirically supported. Overall, this has important consequences for the writers of future constitutions. If reformers desire longevity for their new constitutional framework, they must be aware that utopian promises may backfire by provoking a quick replacement of their rules.
Evaluating measurement invariance of students’ practices regarding online information questionnaire in PISA 2022: a comparative study using MGCFA and alignment method
Authors: Sözer Boz Esra
Published: July 2024

International large-scale assessments provide cross-national data on students’ cognitive and non-cognitive characteristics. A critical methodological issue that often arises in comparing data from cross-national studies is ensuring measurement invariance, indicating that the construct under investigation is the same across the compared groups. This study addresses the measurement invariance of students’ practices regarding online information (ICTINFO) questionnaire across countries in the PISA 2022 cycle. Some methodological complexities have arisen when testing the measurement invariance across the presence of many groups. For testing measurement invariance, the multiple group confirmatory factor analysis (MGCFA), which is a traditional procedure, was employed first, and then a novel approach, the alignment method, was performed. This study comprised 29 OECD countries, with a total sample size of 187.614 15-year-old students. The MGCFA results revealed that metric invariance was achieved across countries, indicating comparable factor loadings while not the same for factor means. Consistent with MGCFA results, the alignment method identified noninvariant parameters exceeding the 25% cut-off criteria across countries. Monte Carlo simulation validated the reliability of the alignment results. This study contributes to international assessments by providing a detailed examination of measurement invariance and comparing the findings from various methodologies for improving assessment accuracy. The results provide evidence-based recommendations for policymakers to ensure fair and equitable evaluations of student performance across different countries, thereby contributing to more reliable and valid international assessments.
Low-temperature fabrication of morphology-controllable Cu2O for electrochemical CO2 reduction
Authors: Dahal Rabin , Ray Schindra Kumar , Pathiraja Gayani , Bastakoti Bishnu Prasad
Published: July 2024

Cu2O has been successfully synthesized in different morphologies/sizes (nanoparticles and octahedrons) via a low-temperature chemical reduction method. Trapping metal ions in an ice cube and letting them slowly melt in a reducing agent solution is the simplest way to control the nanostructure. Enhancement of charge transfer and transportation of ions by Cu2O nanoparticles was shown by cyclic voltammetry and electrochemical impedance spectroscopy measurements. In addition, nanoparticles exhibited higher current densities, the lowest onset potential, and the Tafel slope than others. The Cu2O electrocatalyst (nanoparticles) demonstrated the Faraday efficiencies (FEs) of CO, CH4, and C2H6 up to 11.90, 76.61, and 1.87%, respectively, at −0.30 V versus reference hydrogen electrode, which was relatively higher FEs than other morphologies/sizes. It is mainly attributed to nano-sized, more active sites and oxygen vacancy. In addition, it demonstrated stability over 11 h without any decay of current density. The mechanism related to morphology tuning and electrochemical CO2 reduction reaction was explained. This work provides a possible way to fabricate the different morphologies/sizes of Cu2O at low-temperature chemical reduction methods for obtaining the CO, CH4, and C2H6 products from CO2
Maximal Codimension Collisions and Invariant Measures for Hard Spheres on a Line
Authors: Wilkinson Mark
Published: July 2024

For any $$N\ge 3$$

N
≥
3

, we study invariant measures of the dynamics of N hard spheres whose centres are constrained to lie on a line. In particular, we study the invariant submanifold $$\mathcal {M}$$
M
of the tangent bundle of the hard sphere billiard table comprising initial data that lead to the simultaneous collision of all N hard spheres. Firstly, we obtain a characterisation of those continuously-differentiable N-body scattering maps which generate a billiard dynamics on $$\mathcal {M}$$
M
admitting a canonical weighted Hausdorff measure on $$\mathcal {M}$$
M
(that we term the Liouville measure on$$\mathcal {M}$$
M
) as an invariant measure. We do this by deriving a second boundary-value problem for a fully nonlinear PDE that all such scattering maps satisfy by necessity. Secondly, by solving a family of functional equations, we find sufficient conditions on measures which are absolutely continuous with respect to the Hausdorff measure in order that they be invariant for billiard flows that conserve momentum and energy. Finally, we show that the unique momentum- and energy-conserving linearN-body scattering map yields a billiard dynamics which admits the Liouville measure on $$\mathcal {M}$$
M
as an invariant measure.
Limited memory gradient methods for unconstrained optimization
Authors: Ferrandi Giulia , Hochstenbach Michiel E.
Published: July 2024

The limited memory steepest descent method (LMSD, Fletcher, 2012) for unconstrained optimization problems stores a few past gradients to compute multiple stepsizes at once. We review this method and propose new variants. For strictly convex quadratic objective functions, we study the numerical behavior of different techniques to compute new stepsizes. In particular, we introduce a method to improve the use of harmonic Ritz values. We also show the existence of a secant condition associated with LMSD, where the approximating Hessian is projected onto a low-dimensional space. In the general nonlinear case, we propose two new alternatives to Fletcher’s method: first, the addition of symmetry constraints to the secant condition valid for the quadratic case; second, a perturbation of the last differences between consecutive gradients, to satisfy multiple secant equations simultaneously. We show that Fletcher’s method can also be interpreted from this viewpoint.
A scoping review of food packaging life cycle assessments that account for packaging-related food waste
Authors: Hemachandra Samadhi , Hadjikakou Michalis , Pettigrew Simone
Published: July 2024

Purpose

The aims of this scoping review were to examine the extent to which food packaging life cycle assessment studies included food waste specifically attributed to food packaging, overall and by food category; synthesise outcomes in terms of the ability of packaging solutions to minimise food waste; and identify areas of future research to provide a comprehensive understanding of where future packaging LCA efforts could be directed.

Methods

This article presents a scoping review of 23 peer-reviewed papers on food packaging LCAs that explicitly accounted for packaging-related food waste. The articles were analysed by the major food product categories examined in the LCAs. The review examined the: (i) distribution of LCAs across food product categories, (ii) packaging materials/solutions assessed, (iii) food waste related packaging functions evaluated, and (iv) additional factors that influence packaging-related food waste (e.g., consumer behaviour).

Results and discussion

Most of the reviewed LCAs focused on food categories associated with high environmental impacts such as animal-based products (meat and dairy) and highly perishable products (fresh fruits and vegetables). Plastic was the most frequently evaluated packaging material. Shelf-life extension was the most evaluated food waste related packaging attribute, and was found to play an important role in preventing food waste, especially within high impact food categories.

Conclusions

The small number of studies identified in this review highlights a need for greater attention to food waste across more food categories in future food packaging LCAs. Similarly, there is considerable potential for greater consideration of packaging attributes relevant to different food product categories.
Hypercoagulable state and effect of low-molecular-weight heparin prophylaxis on coagulation after lung cancer resection: results from thrombo-elastography
Authors: Yang Xiaoxiao , Cai Yongsheng , Ke Lihui , Wei Bo
Published: July 2024

Background

Lung cancer patients undergoing surgery are at increased risk for Venous thromboembolism (VTE). We monitored changes in perioperative coagulation status through Thrombo-elastography (TEG), and monitored the anticoagulant effect of low molecular weight heparin through TEG for the first time.

Methods

From July 2019 to January 2020, 207 patients receiving curative surgery were retrospectively screened. and 23 patients were excluded because they did not meet the inclusion criteria. Blood samples were required at three time points (prior to, the first and third day after surgery). Some patients were administrated nadroparin calcium daily from the first day after surgery. Repeated measures ANOVA and Chi-square test were used to analyze the coagulation states variation. To balance the confounders, propensity score matching (PSM) was used to determine the differences of coagulation states between patients with or without Low-molecular-weight heparin (LMWH) prophylaxis.

Results

In 184 patients, TEG parameters displayed significant procoagulant changes after lung surgery but conventional coagulation tests exhibited paradoxical trends. There were 6.5% (12/184) of patients identified as hypercoagulability before surgery. According to TEG results, the proportion of patients with hypercoagulability rose from 21.7% to 25% postoperatively, but more were classified into platelet or mixed hypercoagulability at third day compared with that at first day (3.8% vs 14.1%, P < 0.001). By PSM analysis, there were no significant differences in the proportion of hypercoagulable patients postoperatively between chemoprophylactic and nonprophylactic group.

Conclusions

TEG was eligible to distinguish changing states of hypercoagulability postoperatively and indicate the role of platelet in blood hypercoagulability. Administration of postoperative LMWH prophylaxis showed little mitigation on hypercoagulable states.
Large Process Models: A Vision for Business Process Management in the Age of Generative AI
Authors: Kampik Timotheus , Warmuth Christian , Rebmann Adrian , Agam Ron , Egger Lukas N. P. , Gerber Andreas , Hoffart Johannes , Kolk Jonas , Herzig Philipp , Decker Gero , van der Aa Han , Polyvyanyy Artem , Rinderle-Ma Stefanie , Weber Ingo , Weidlich Matthias
Published: July 2024

The continued success of Large Language Models (LLMs) and other generative artificial intelligence approaches highlights the advantages that large information corpora can have over rigidly defined symbolic models, but also serves as a proof-point of the challenges that purely statistics-based approaches have in terms of safety and trustworthiness. As a framework for contextualizing the potential, as well as the limitations of LLMs and other foundation model-based technologies, we propose the concept of a Large Process Model (LPM) that combines the correlation power of LLMs with the analytical precision and reliability of knowledge-based systems and automated reasoning approaches. LPMs are envisioned to directly utilize the wealth of process management experience that experts have accumulated, as well as process performance data of organizations with diverse characteristics, e.g., regarding size, region, or industry. In this vision, the proposed LPM would enable organizations to receive context-specific (tailored) process and other business models, analytical deep-dives, and improvement recommendations. As such, it would allow to substantially decrease the time and effort required for business transformation, while also allowing for deeper, more impactful, and more actionable insights than previously possible. We argue that implementing an LPM is feasible, but also highlight limitations and research challenges that need to be solved to implement particular aspects of the LPM vision.
A practice already in use: a snapshot survey on the use of doxycycline as a preventive strategy (Doxy-PEP and Doxy-PrEP) in the GBMSM population in Spain
Authors: Sergio Villanueva Baselga , Ruben Mora , Luis Villegas
Published: July 2024

Purpose

. While doxycycline shows promise as a preventative measure against certain STIs (post-exposure prophylaxis or PEP, and pre-exposure prophylaxis or PrEP), very few medical and scientific associations favor its community use. Nevertheless, sexual health organizations for gay, bisexual and other men who have sex with men (GBMSM) community have noticed an increase in requests of its use.

Methods

. The sexual health organization “Stop Sida” in Spain launched an anonymous snapshot survey to evaluate the current use of doxycycline as prevention strategy (both PEP and PrEP) in Spain through its social networks and its support groups in telegram.

Results

. 150 valid answers were obtained from different parts of Spain. 82 respondents (54,6% of total) had ever taken doxycycline, out of which 29 (35,4%) indicated the use as doxy-PEP and 7 (8,5%) as doxy-PrEP. The self-reported rate of STI diagnoses (mainly of syphilis and chlamydia) in the past 12 months was lower among those participants who reported having used doxy-PEP compared with those who did not report using doxy-PEP. The most common ways to obtain the doxycycline were telling a specialist that they have had a risky contact or by using leftover pills from a previous treatment.

Conclusion

The current study is the first study to describe the use of doxycycline as a preventive strategy among the GBMSM community in Spain, and the first designed, launched and analyzed entirely by an NGO dealing with sexual health for the GBMSM community. The results obtained are aligned with other studies in other parts of Europe, such as Germany.
Identification methods for ordinal potential differential games
Authors: Varga Balint , Huang Da , Hohmann Sören
Published: July 2024

This paper introduces two new identification methods for linear quadratic (LQ) ordinal potential differential games (OPDGs). Potential games are notable for their benefits, such as the computability and guaranteed existence of Nash Equilibria. While previous research has analyzed ordinal potential static games, their applicability to various engineering applications remains limited. Despite the earlier introduction of OPDGs, a systematic method for identifying a potential game for a given LQ differential game has not yet been developed. To address this gap, we propose two identification methods to provide the quadratic potential cost function for a given LQ differential game. Both methods are based on linear matrix inequalities (LMIs). The first method aims to minimize the condition number of the potential cost function’s parameters, offering a faster and more precise technique compared to earlier solutions. In addition, we present an evaluation of the feasibility of the structural requirements of the system. The second method, with a less rigid formulation, can identify LQ OPDGs in cases where the first method fails. These novel identification methods are verified through simulations, demonstrating their advantages and potential in designing and analyzing cooperative control systems.
Association between ambient fine particular matter components and subsequent cognitive impairment in community-dwelling older people: a prospective cohort study from eastern China
Authors: Zhang Tao , Liu Wenfeng , Yang Tao , Zhai Yujia , Gu Xue , Xu Le , Li Fudong , Wu Mengna , Lin Junfen
Published: July 2024

Background

Fine particular matter (PM2.5) has been associated with dementia, but limited information is available regarding the association between PM2.5 components and dementia.

Aims

We aimed to identify the major components of PM2.5 that affect cognitive function to further investigate its mechanism of action, and develop a prevention strategy for dementia.

Methods

In this study, we included 7804 participants aged ≥ 60 years recruited from seven counties in Zhejiang province, eastern China. The participants completed the baseline survey between 2014 and 2015, and were followed up until the end of 2020. We adopted single-component robust Poisson regression models for analyses, and estimated relative risks and 95% confidence intervals describing associations between the chemical constituents of PM2.5 exposure and incident cognitive impairment in those who were free from cognitive impairment at baseline.

Results

Significantly positive associations were observed between sulfate, nitrate, ammonium, and organic matter in PM2.5 and incident cognitive impairment across different exposure periods; the relative risks of 10-year exposure before enrollment ranged from 1.01 to 1.02. However, we did not find a significant association between black carbon and cognitive impairment. The point estimates of the relative risk values did not change substantially after performing the sensitivity analyses.

Conclusions

Our findings strengthen the idea that long-term exposure to PM2.5 mass and its chemical components is associated with an elevated risk of incident cognitive impairment among older adults.
Salinity Tolerance of Diplotaxis tenuifolia Varieties Growing in Spring–Summer Season Under Mediterranean Greenhouse and Optimal Growing Conditions
Authors: Cacini Sonia , Deligios Paola Antonia , Massa Daniele , Tripodi Pasquale , Alchera Federica , Ledda Luigi , Ginepro Marco , Melito Sara
Published: July 2024

Salinity is one of the principal abiotic stresses that occurs in the Mediterranean area, causing loss of productivity and decrease of vegetable crop quality. The effect of salinity (0, 25, 75, 150 mM NaCl) was evaluated in three Diplotaxis tenuifolia varieties (Dragon Tongue, Capriccio, Piccante), previously selected for salinity tolerance and high glucosinolates production in leaves. The aim of this research was to explore the salinity tolerance of three wild rocket varieties cultivated under optimal temperature conditions and under high temperature that typically characterized the Mediterranean greenhouse. Biometric, biomass, pigment production and physiological parameters were evaluated. Biometric, physiological, and biochemical parameters significantly varied because of variety, salt level used and environmental conditions. PCA analysis highlighted that the two cultivation systems deeply affected the wild rockets response to salt stress. In general, under optimal growing conditions, wild rocket varieties showed higher growth parameters compared to greenhouse conditions. Overall Capriccio was the most susceptible variety to salinity, while Dragon Tongue (V1) and Piccante (V3) were more tolerant to salt stress. Furthermore, in both growing conditions V1 was the less productive variety while V3 showed an opposite trend. Interestingly, gene (DtOxo and DtGst) expression analysis revealed a significant increase of the target gene expression as response of salinity levels, with a clear increase of DtOxo level in V1 and V3. The results obtained in this study can be useful to plan future breeding programs aimed to increase rocket quality grown under Mediterranean conditions.
AI-based adaptive instructional systems for maritime safety training: a systematic literature review
Authors: Karimi Elham , Smith Jennifer , Billard Randy , Veitch Brian
Published: July 2024

Adaptive instructional systems (AISs) refer to educational interventions designed to accommodate individual learner differences. These systems employ various approaches, such as artificial intelligence (AI), machine learning (ML), and data analytics, to analyze student performance and personalize the learning experience. This article presents a review of the current state-of-the-art of AI methods used in the development of AISs for maritime safety training. The main objective of this systematic literature review is to determine the use of AI/ML techniques in AIS and how they can contribute to the development of AIS for maritime education and training (MET) applications in addressing small data problems. Answering the research questions of the review identifies the fundamental purposes of using AI/ML techniques in developing AIS for MET. Further, the review highlights several crucial research areas, including AI techniques for modelling student and instructor knowledge, as well as ML algorithms for predicting student performance in situations with limited datasets.
PM2.5 and heavy metals in urban and agro-industrial areas: health risk assessment considerations
Authors: Park Shin-young , Jeon Jeong-In , Jung Ji-Yun , Yoon Sung-Won , Kwon Jaymin , Lee Cheol-Min
Published: July 2024

The study investigated PM2.5 and heavy metal pollutant concentrations in Seoul and Wonju, South Korea, emphasizing the importance of considering PM2.5 chemical constituents for health impact assessments. While PM2.5 concentrations were similar between the two cities with slight variations, heavy metal concentrations differed significantly. Regional sources, PM2.5 composition, and meteorological conditions influenced these variations. Exposure to Fe was highest in all areas, with some heavy metals exceeding permissible levels, stressing the need to consider regional characteristics in assessments. Different heavy metals influence health risks differently in each city. When examining the HI (the summation of the hazard quotient for heavy metals), Seoul remained below an HI value of 1, while Wonju exceeded this threshold when exposed to CTE concentrations. In Seoul, As had a significant health impact of PM2.5, while in Wonju, Mn was more influential. Source apportionment confirmed different pollution sources in Seoul and Wonju, affecting the distribution of PM2.5 constituents in the atmosphere. Effective PM2.5 management requires a comprehensive approach considering chemical constituents and health impacts not just mass-based PM2.5 management, emphasizing regional-specific assessments and policy considerations to mitigate health risks. Therefore, tailored management strategies based on regional characteristics are necessary.

Graphical Abstract
Spatio-temporal variation of aerosol optical depth and black carbon mass concentration over five airports across Bangladesh: emphasis on effect of COVID-19 lockdown
Authors: Joy Khaled Shaifullah , Zaman Shahid Uz , Pavel Md. Riad Sarkar , Islam Md. Safiqul , Salam Abdus
Published: July 2024

Globally, the COVID-19 outbreak has had a devastating impact on both health and economy. In contrast, the reduction in anthropogenic emissions has resulted in a major improvement in air quality. In this study, US National Aeronautics and Space Administration (NASA) satellite datasets and related reanalysis model data were used with validation using ground-based data to evaluate the effects of aviation-based emissions on aerosol optical depth (AOD) and black carbon (BC). The contributions from five airports in Bangladesh were assessed during the pre-lockdown (01 Jan to 22 March), lockdown (23 March to 30 May), and post-lockdown (31 May to 30 Aug) periods in 2019 and 2020. The study’s findings show that during the 2020 lockdown, AOD and BC concentrations significantly decreased at all five airports. The overall decline of AOD was ~ 18.5% (13.1% to 22.8%) and BC was ~ 18.1% (16.6% to 22.2%) in 2020 compared to 2019. The three international airports that were examined—Dhaka, Chattagram, and Sylhet—showed an average reduction of about ~ 9.7%, while Jashore and Barisal—two domestic airports—saw a minor increase in AOD of ~ 0.8% over the same period. However, the average BC concentration at both international and domestic airports dropped by ~ 9.8% and ~ 10.2%, respectively. This is the first study to use reanalysis datasets in Bangladesh to evaluate air pollution levels and aviation-based emissions. The results highlight the significant impact of reduced aviation activity on air quality and provide valuable insights for future air pollution management strategies.

Graphical Abstract