bluuebunny/crossref_metadata_2025 huggingface dataset:
A Systems Biology Approach Unveils a Critical Role of DPP4 in Upper Gastrointestinal Cancer Patient Outcomes
Authors: Kotnala Sudhir , Dhasmana Anupam , Dhasmana Swati , Haque Shafiul , Yallapu Murali M. , Tripathi Manish K. , Jaggi Meena , Chauhan Subhash C.
Published: August 2023

Gastrointestinal (GI) cancers comprise of cancers that affect the digestive system and its accessory organs. The late detection and poor prognosis of GI cancer emphasizes the importance of identifying reliable and precise biomarkers for early diagnosis and prediction of prognosis. The membrane-bound glycoprotein dipeptidyl-peptidase 4 (DPP4), also known as CD26, is ubiquitously expressed and has a wide spectrum of biological roles. The role of DPP4/CD26 in tumor progression in different types of cancers remains elusive. However, the link between DPP4 and tumor-infiltrating cells, as well as its prognostic significance in malignancies, still require further investigation. This study was intended to elucidate the correlation of DPP4 expression and survival along with prognosis, followed by its associated enriched molecular pathways and immune cell marker levels in upper GI cancers. Results demonstrated a strong correlation between increased DPP4 expression and a worse prognosis in esophageal and gastric cancer and the co-expressed common genes with DPP4 were associated with crucial molecular pathways involved in tumorigenesis. Additionally, DPP4 was shown to be significantly linked to several immune infiltrating cell marker genes, including Macrophages (M1, M2 and Tumor Associated Macrophages), neutrophils, Treg, T-cell exhaustion, Th1 and Th2. Overall, our findings suggest that DPP4 may serve as a substantial prognostic biomarker, a possible therapeutic target, as well as it can play a critical role in the regulation of immune cell invasion in patients with gastroesophageal (esophageal, gastroesophageal junction and gastric) cancer.
KEY WORDS: DPP4, integrated analysis, GI cancer, gastroesophageal cancer, gastroesophageal junction, prognosis
HALL CURRENTS AND ION SLIP EFFECT ON SISKO NANOFLUID FLOW FEATURING CHEMICAL REACTION OVER POROUS MEDIUM-A STATISTICAL APPROACH
Authors: Nisha S. Siraj , De Poulomi
Published: August 2023

This paper focuses on the statistical analyzing of hall currents and the ion slip effect on Sisko nanofluid. The present analysis of the flow deals with chemical reaction, porous medium, and magnetohydrodynamic flow over a stretching sheet. Applications of the present study are found in predicting sheer rates, lubricating oil and greases, and making non-structured materials. Its industrial applications include reduction in oil-pipeline function, surfactant for comprehensive cooling and heating system and flow traces. The non-linear partial differential equations are converted into ordinary differential equations using convective boundary conditions by utilizing similarity transformations. The ordinary differential equation is solved numerically by applying the fifth order Runge-Kutta-Fehlberg scheme via shooting technique. The impact of various non-dimensional flow parameters on velocity, temperature, and concentration distributions are analyzed and exemplified graphically. The results compare favorably with previously published works.
The statistical analysis indicates that the correlation coefficients of parameters A, k, Nt, and Kc are remarkable to the physical attributes. Results indicate that an increase in hall current and chemical reaction enhances the temperature and reduces the concentration profile.
Machine Vision and Tagging Aesthetics: Assembling Socio-Technical Subjects through New Media Art
Authors: Bozzi Nicola
Published: August 2023

This paper builds on the concept of ‘tagging aesthetics’ (Bozzi, 2020b) to discuss new media art projects that combine machine vision and social media to address how different kinds of socio-technical subjects are assembled through AI. The premise outlines how the naturalisation of machine vision involves a range of subjects, juxtaposed along different conflictual lines: ontological (human-machine), biopolitical (classifier-classified), socio-technical (tech worker-data cleaner), political (AI-viewing public). Embracing the ambiguity inherent in the shifting boundaries of these subjects, I analyse works by different new media artists who approach one or more of these juxtapositions by engaging with diverse forms of tagging. The practice of tagging is often discussed through data-driven analyses of hashtags and how related publics can be mapped, but in my framework, tagging can encompass a wider spectrum of techno-social practices of connection (e.g. geotagging, tagging users). I discuss artworks by Kate Crawford and Trevor Paglen, Dries Depoorter and Max Dovey to illustrate how these practices can be leveraged artistically to make visible and even ‘stitch together’ the manifold subjects of machine vision. I explain how those taggings denaturalise processes of socio-technical classification by activating awareness, if not agency, through the sheer proximity they enact. Far from being a tool to map knowledge and essentialised identities, tagging aesthetics are ways to perform the techno-social and shape future cultural encounters with various forms of others. By exploring different approaches to tagging aesthetics – (dis)identification, semi-automated assembly and embodied encounter – this paper illustrates how tagging can be used to culturally negotiate the impact of machine vision in terms of issues such as surveillance and the performance of digital identity.
Nurses’ perceptions of gerontological nurse practitioner programme curricula: A qualitative descriptive study
Authors: Park Jongsun , Kim Hyejin
Published: August 2023

Purpose: This study aimed to describe nurses’ perceptions of gerontological nurse practitioner (GNP) programme curricula, especially positive and negative aspects of the curricula and suggestions to improve the curricula. Methods: Twenty-one certified GNPs attended one or two interviews and the data obtained were analysed using a conventional content analytic method. Results: The analysis revealed seven categories and 18 subcategories. The main positive aspects of the GNP programme curricula were “Acquiring knowledge and skills to elder care through the GNP programme” and “Application of gerontological nursing-related knowledge and skills attained from the GNP programme.” The negative aspects included “Didactic education insufficient for the development of expertise in gerontological nursing” and “Ineffective and suboptimal operation of clinical practice curriculum.” Suggestions to improve the GNP programme curricula were “Enhancement of education in core courses,” “Strengthening the contents of gerontological nursing didactic courses,” and “Quality improvement of clinical practice.” Conclusion: The findings indicate that educators, policymakers, and other stakeholders should re-examine the current GNP programme curricula to provide GNP students with quality education and training pertinent to professional healthcare for older adults in various healthcare settings.
Health-related quality of life for older patients with chronic low back pain: A structural equation modeling study
Authors: Lee Suin , Lee Eun-Ju
Published: August 2023

Purpose : This study aimed to develop and validate a structural equation model for health-related quality of life in older patients with chronic low back pain. Methods : We selected social support, symptoms, fear-avoidance beliefs, functional disability, health perception, and health-related quality of life as the main variables based on Wilson and Cleary’s model of health-related quality of life. A total of 211 participants aged ≥65 years who had been diagnosed with low back pain for more than three months were considered in this study. Data were collected from two hospitals in D Metropolitan City and A City, one public health center, and two senior citizen centers. We utilized SPSS/WIN 24.0 and R package ‘plspm’ (R Version 3.1.3) for data analysis. Results : The overall fit of proposed hypothesized model was .53, which met the acceptable threshold, confirming the adequacy of the model’s fit. Social support, symptoms, fear-avoidance beliefs, functional disability, and health perception were statistically significant variables in the health-related quality of life, and the explanatory power of these variables was 75.1%. Out of the 15 hypotheses in the model, 13 hypotheses were supported. Conclusion : The model showed 12 significant direct effects, one significant indirect effect, and 13 significant total effects (both direct and indirect). To enhance the health-related quality of life in older patients with chronic low back pain, alleviating fear-avoidance beliefs and functional disability is necessary, while improving positive social resources such as social support and health perception is essential.
Factors influencing fall in the community-dwelling elderly: Data from the 2020 national survey of older people: A secondary analysis study
Authors: Lee Chang Kwan
Published: August 2023

Purpose: This study was performed to identify the factors influencing fall in the community-dwelling elderly using the raw data of the 2020 national older Koreans data. Methods: The study included 9,920 community-dwelling seniors aged 65 years and older. The data were analyzed by using a complex sampling design univariate logistic regression analysis. Results: Although the subjects of this study were 9,920 people, it can be generalized to 7,617,710 people because it is a probability sample using the stratified systematic sampling with cluster plots. As a result of this study, the fall rate of community-dwelling elderly was 6.4% and the weighted percentage was 7.1%. Satisfaction with economic status, number of chronic diseases, use of medical facilities, smoking, limitation of lower muscle strength, decreased visual acuity, limitation of daily living function, and housing type were identified as factors influencing fall in older people dwelling in the community. Conclusion: Based on the variables identified in this study, it is necessary for nurses to select high-risk groups for fall and to actively develop and implement nursing intervention to prevent fall.
Fundamental Movement Skills in Children in Mentawai Islands: Indigenous Tribes in Indonesia
Authors: Komaini Anton , Kiram Yanuar , Gusril  , Mario Deby Tri , Handayani Sri Gusti , Erianjoni
Published: August 2023

Background and purpose. Various studies have investigated Fundamental Movement Skills (FMS) in children and factors that might improve them. However, studies examining FMS in children of indigenous tribes remain limited. Thus, this research aims to identify and analyze the relationship between sociocultural life, parenting, and level of education among indigenous tribe children who live on Mentawai Island. The research is also keen on comparing FMS between genders. 
Materials and methods. This research employed qualitative and quantitative methods. It was grounded by phenomenology and FMS tests. A total of 15 parents, 3 teachers, and 70 young children (aged 5-7 years) participated voluntarily. The children’s genders comprised boys (n=38) and girls (n=32). Data in this research were collected from observation, semi-structured interviews, and FMS tests (locomotor, non-locomotor and manipulative). Then, they were analyzed using a thematic method and t-test to compare the level of FMS among the children. 
Results. Based on the analysis, parents stated they involved their children in socio-cultural life. Also, children were educated to live independently and given freedom to play. However, the study did not find any relationship between parent’s educational level and FMS. This was evidenced by statistical analysis, in which the mean score of FMS among early childhood in Mentawai Island was 35.46 (good). Following that, boys had better FMS than girls (P<0,05), with a mean score of 37.08>33.53.
Conclusions. Children need to be given the freedom to actively take part in physical activities in order to gain physical experiences and better FMS. This study recommends future research involving other factors and comparing FMS between children of indigenous tribes and those who live in urban areas.
Plyometric Hurdle Jump Training Using Beach Sand Media Increases Power and Muscle Strength in Young Adult Males
Authors: Bulqini Arif , Widodo Achmad , Nurhasan  , Muhammad Heriyanto Nur , Putera Shidqi Hamdi Pratama , Sholikhah Anindya Mar’atus
Published: August 2023

The study purpose was to analyze the effectiveness of the different effects of knee tuck jump and hurdle jump plyometric training using beach sand on power and leg muscle strength in young adult males. Materials and methods. A total of 30 young adult males were enrolled in this study and were given plyometric knee tuck jump training (KTJT), and plyometric hurdle jump training (HJPT). Plyometric training is carried out with an intensity of 80-100% of 1RM, three sets with 12 repetitions each set, with a frequency of three times each week for six weeks. The measurement of leg muscle power uses the Jump Meter Digital (MD) Test, while the measurement of leg muscle strength uses the Back & Leg Dynamometer. Statistical analysis used one-way ANOVA and continued with the Least Significant Difference (LSD) post hoc test. Results. The results of the analysis are as follows: the mean ∆ increase in muscle power on CTRL (12.92±2.51 joule) vs. KTJT (142.88±35.21 joule) vs. HJPT (269.49±138.06 joule), (p=0.000). The mean ∆ increase in muscle strength on CTRL (11.61±1.49 kg) vs. KTJT (75.49±18.53 kg) vs. HJPT (137.43±34.13 kg), (p=0.000). Conclusions. Based on the results of the study, it was concluded that both types of plyometric training improve power and strength in young adult males.
Through Dialogue with the Past to Finding the Future: Some Aspects of Gavriil V. Derzhavin’s Legacy for the Development of Modern Russian Jurisprudence
Authors: Kabyshev S. V.
Published: August 2023

The paper provides an expanded version of the theses of the author’s report delivered at the scientific and educational conference «Your duty is to preserve the laws … " dedicated to the 280th anniversary of Gavriil Romanovich Derzhavin held at the Kutafin Moscow State Law University (MSAL) on July 5, 2023. The paper deals with the issues of understanding of law as the initial category of jurisprudence in Derzhavin’s ideological and creative semantic space and understanding of the Constitution, bearing in mind G. R. Derzhavin participation in the formation of the project-doctrinal origins of Russian constitutionalism. The author focuses on ideological and spiritual legacy of G. R. Derzhavin directly reflected in his state-political and literary-creative biography. The author, relying on the concept of constitutional dialogue with the past put forward by Derzhavin, reveals a comprehensive creative potential of Derzhavin’s philosophy of state-legal life for the formation of value-semantic, pedagogical and institutional foundations of a nationally oriented constitutional model of the development of sovereign Russian statehood in modern conditions.
Bone mineral density radiopaque templates for cone beam computed tomography and multidetector computed tomography
Authors: Hossain Shazmim D. , Petraikin Alexey V. , Muraev Alexandr A. , Danaev Aslan B. , Burenchev Dmitry V. , Dolgalev Alexander A. , Vasilev Yuriy A. , Sharova Darya E. , Ivanov Sergey Yu.
Published: August 2023

BACKGROUND: Cone beam computed tomography is widely applied for diagnostics and planning various manipulations in the maxillofacial region, for example, dental implantation. Its advantages include high spatial resolution, low radiation exposure, and cost-effectiveness. However, it has a significant drawback: the inability to determine the density of the jaw bone in Hounsfield Units (HU).
AIMS: This study aimed to develop radiopaque templates with sets of X-ray density based on potassium hydrophosphate and beta-tricalcium phosphate, to study templates on various cone beam computed tomography and multidetector computed tomography devices, and to determine a cross-calibration algorithm for assessing the bone mineral density of the jaw in HU.
MATERIALS AND METHODS: The bone mineral density template comprised microtubes (0.25 ml) with potassium hydrophosphate concentrations of 49.96, 99.98, 174.99, 349.99, and 549.98 mg/ml, and a suspension of beta-tricalcium phosphate with an equivalent concentration of potassium hydrophosphate 1,506 mg/ml, designed to simulate the types of bone density according to C. Mish. The study was carried out on two multidetector computed tomography and four cone beam computed tomography machines. Cross-calibration was referred on the standard multidetector computed tomography 1 mode 120 kV, 200 mA.
RESULTS: There was a significant scatter of the X-ray values (HU for multidetector computed tomography and GV for cone beam computed tomography) vs. bone mineral density, with varying slopes, bias, and curve shapes. After cross-calibration, good comparability corresponding to the multidetector computed tomography 1 mode was shown. The median of the differences before cross-calibration was 160 relative units (HU, GV), after decreased by 10 times and amounted to 16 rel. units (p=0.000). The mean difference for cone beam computed tomography was significantly higher (30 rel. units) than for multidetector computed tomography (8 rel. units) (p=0.024, MannWhitney U test).
CONCLUSION: The developed radiopaque template enables the standardization of densitometric indicators for cone beam computed tomography and various multidetector computed tomography modes. On average, the spread after cross-calibration is reduced by 10 times, which makes it possible to classify bone tissue in HU according to C. Mish.
Mechanically Coupled Areas on the Plate Interface in the Kanto Region, Central Japan, Generating Great Earthquakes and Slow-Slip Events
Authors: Saito Tatsuhiko , Noda Akemi
Published: August 2023

We detected the mechanically coupled areas, or high stress rate patches, on the plate interface in the Kanto region, central Japan, by analyzing the Global Navigation Satellite Systems data. The estimated patches correspond well with the focal areas of past great earthquakes and slow-slip events (Mw∼6.5) occurring every ∼5 yr. Using one of the estimated patches, we created a model of a slow-slip event as a stress release with a recurrence interval of 5 yr. This synthetic can reproduce observed features of the slow-slip events such as the slip distribution and the magnitude. We use the strain-energy magnitude Mw0 defined by the minimum strain-energy release to quantify the magnitude. This is useful to compare slow-slip events with ordinary earthquakes in terms of the strain energy release, whereas the moment magnitude does not represent the difference of the energy release in this case. The strain-energy magnitude of the slow-slip event was Mw0 4.9, which was considerably smaller than the moment magnitude, because the smaller stress drop of the slow-slip event results in a smaller strain-energy release. Furthermore, by assuming that stress has accumulated at the other patches corresponding to the source region of past earthquakes since the occurrence of the last earthquakes, we obtain a model of the stress accumulation in 2023. We then create various rupture scenarios of great earthquakes as combinations of ruptures of the different patches. When two or three of the patches release the accumulated stress simultaneously, an interplate earthquake with Mw≥7.8 can occur in the Kanto region.
Identification of Repeating Earthquakes: Controversy and Rectification
Authors: Gao Dawei , Kao Honn , Liu Jianxin
Published: August 2023

Repeating earthquakes (repeaters) are events that recurrently rupture the same fault patch with nearly identical magnitudes. Although repeaters have been widely studied and utilized in many fields over the last four decades, there are no standard criteria for reliably identifying such events. The current criteria adopted in the geophysical research community are inconsistent and difficult to justify. Different criteria may inescapably incur inadequate hypotheses and lead to controversial interpretations, highlighting the urgent need for seeking a uniform approach to reliably identify repeaters. In this study, we address this long-standing issue by deriving the most logical criteria on the basis of theoretical calculation with simple yet reasonable assumptions. Quantitatively, we define a repeating pair if their interevent distance is ≤80% of the rupture area of the larger event and their magnitude difference is ≤0.3. We demonstrate the superiority of our proposed approach with challenging cases in California, and our results shed new insight into the hierarchical fault structures in the source areas. Although this study focuses on defining repeating earthquakes, the application to repeating seismic events in other planetary bodies such as moonquakes and marsquakes is straightforward, potentially help avoid misinterpretations of the physical processes in both Earth and planetary interiors.
A ‘Thank You’ to Editor-in-Chief Emeritus Thomas Baker
Authors: Rodenberg Ryan
Published: August 2023

In 2015, Dr. Thomas Baker penned his first ‘Editor’s Note’ in the Journal of Legal Aspects of Sport (JLAS). Eight years and 15 issues of JLAS after his initial editor’s note, I write to say ‘thank you’ to Dr. Baker for his editorial stewardship. Indeed, the entire sport law community owes Dr. Baker a debt of gratitude for his work in advancing JLAS.
Sepsis-attenuated myocardial function: pathogenesis of injury with neutrophil recruitment crosstalk
Authors: Sarfaraz Hussain , Imran Basmah , Abidi Sharaf
Published: August 2023

Acute myocardial injury may be induced by different causes, including myocardial ischemia-reperfusion injury, and sepsis, which represent the most common reasons for cardiac injury in hospitalized patients. Sepsis-induced myocardial injury is considered not to be associated with leukocyte infiltration into the myocytes but is shared with many crosstalk pathogeneses. In this experimental animal study, polymicrobial sepsis-induced was via cecal ligation and puncture model (CLP), in C57BL/6 male mice (25–30 g). By using neutrophil knockout mice, in which neutrophil recruitment is impaired, we analyzed the specific contribution to the pathogenesis of CLP-induced attenuated myocardial function. We investigated the degree of myocardial injury evaluated by plasma troponin, echocardiography, and histological analyses. The pathogenesis of CLP-induced myocardial injury relies on circulating inflammatory mediators. In conclusion, these resulting data explained that myocardial injury pathogenesis may help in the treatments for myocardial injury patients.
New possibilities of combining multimodal game modeling and cardiometric detection in instrumental cognitive science
Authors: Ognev A.S.
Published: August 2023

The article presents experimental results indicating the high efficiency of using in instrumental cognitive science some sand patterns on light tablets, created by respondents as illustrations of their problems, and possible ways to solve them. It is shown that the creation of such stimuli is less labor-intensive compared to the use of other types of multimodal game modeling for the same purposes, and it is noted that this procedure causes less resistance by respondents to the upcoming instrumental diagnostics and may well serve as an operational means for conducting large-scale studies of cognitive processes, during which the subjects will have to set semantic priorities and make vital decisions.
Socio-economic determinants of environmental degradation: empirical evidence for the environmental Kuznets Curve
Authors: Gültekin Ömer Faruk , Sayar Ramazan , Ari Yılmaz Onur
Published: August 2023

The aim of the paper is to examine socio-economic determinants of environmental degradation. The empirical study employs quantile regression which enables separate predictions for different levels of the dependent variable to be made. This study investigated 62 countries from low, middle and some high income countries for 1995-2019. The Environmental Kuznets Curve (EKC) is verified for the aforemented countries in analyzing the relationship between economic growth and carbon emissions using quantile regression. The study also revealed that the schooling rate has a pollution-increasing effect. In addition to the reducing effects of trade openness, democracy, and economic freedom variables on environmental degradation, the opposite effect of life expectancy at birth is observed, increasing environmental degradation. In this context,  this paper concluded that the EKC hypothesis is not supported. The government should encourage pollution-reducing policies in low and middle income countries.
The relationship between social capital and economic growth on a provincial and regional basis
Authors: Pilatin Abdulmuttalip , Hacıimamoğlu Tunahan
Published: August 2023

The aim of this study is to investigate the relationship between economic growth and social capital on both a provincial and regional basis in Turkey during the period of 2007-2018. In the study, in which the social capital index was used as a current and comprehensive variable to represent social capital, the relations between the variables were analyzed with the panel Granger causality test. As a result of the empirical analysis, it was determined that there is a unilateral causality relationship from GDP to SOCAP in 16 provinces, from SOCAP to GDP in 9 provinces, and bilateral causality in 45 provinces. On the other hand, no significant relationship was found in 11 provinces.
The choice of external financing source: The role of company size and stock liquidity
Authors: Stereńczak Szymon , Kubiak Jarosław
Published: August 2023

This paper aims to answer whether firms of different sizes and stock liquidities differ in the choice of external sources of financing in companies listed in CEE countries. To this end the net debt issuance is regressed on the financial deficit. In regressions Pecking Order Coefficients are allowed to vary across firms with different sizes and stock liquidities. The results indicate that companies with less liquid shares prefer issuing debt to cover financial deficits more than companies with more liquid shares. This implies that stock liquidity may substitute debt issuance in alleviating the adverse effects of information asymmetry, especially in relatively small companies. This is the first study in which the relationship between liquidity and debt-equity choice is considered solely from a pecking order theory point of view. Also this is the first study in which stock liquidity effects on capital structure are studied in the CEE countries. Research results may point to the advantages of increasing the liquidity of shares which may contribute to reducing information asymmetry and thus a better allocation of resources.
Judges without Robes: A Republican Approach to Participatory Judicial Review
Authors: Cortés-Arbeláez Alejandro
Published: August 2023

Este artículo presenta un enfoque republicano del control judicial de constitucionalidad de las leyes que se basa en una interpretación deliberativa y participativa de este arreglo institucional. El documento se divide en cinco secciones, más una introducción. La Sección I presenta algunas consideraciones y aclaraciones sobre el concepto de control judicial y el tipo de teoría política republicana que subyace a los principales argumentos del trabajo. La Sección II reconstruye la crítica republicana al control judicial. La Sección III muestra que suscribir una perspectiva republicana no necesariamente lleva a respaldar esta crítica y presenta una defensa del control judicial que se apoya en una concepción republicana de la democracia deliberativa que enfatiza el potencial de esta institución como un mecanismo que sirve para promover la participación política en igualdad de condiciones y que, por tanto, dota al control judicial de una legitimidad democrática participativa. La Sección IV argumenta que la legitimidad democrática participativa del control judicial debe ser vista como un fenómeno gradual cuya fuerza o debilidad relativa depende de las variaciones de las características específicas del contexto institucional donde opera el poder judicial. La Sección V presenta algunas conclusiones.
Private Military and Security Companies, Responsibility of States and International Humanitarian Law: Toward an Interdisciplinary Definition
Authors: Urueña-Sánchez Mario , Olásolo Héctor
Published: August 2023

El objetivo del artículo es doble. En primer lugar, identificar los elementos que distinguen a las Compañías militares y de seguridad privadas (CMSP) de otras entidades. En segundo lugar, proponer una definición de las CMSP en el derecho internacional humanitario (DIH). La hipótesis del estudio es que el tipo de servicios militares prestados por las CMSP, su participación directa en las hostilidades y las llamadas “tres externalidades” son los elementos centrales de las CMSP y brindan una base sólida para su definición en el DIH. La metodología de investigación aplicada se basa en la orientación epistemológica interpretativista, la cual se refleja a través de una pregunta de investigación abierta que busca examinar una serie de elementos y procesos observables que contribuyen a determinar el resultado. Para ello, la pregunta de investigación se formula de tal forma que el análisis propuesto ilustra la forma en que los agentes sociales e internacionales representan “el mundo” y un objeto de estudio (las CMSP y su personal) a través de sus interpretaciones intersubjetivas. Esta es la preferida por el pluralismo metodológico y los enfoques interdisciplinarios.
ASPECTOS HISTÓRICO-LEGAIS E TEÓRICOS DO ESTÁGIO SUPERVISIONADO
Authors: Alves Francione Charapa , Santos Cicera Maria Mamede
Published: August 2023

Este artigo objetiva apresentar aspectos histórico-legais sobre o componente curricular estágio supervisionado, dialogando com os aspectos teóricos que o sustentam. Trata-se de pesquisa qualitativa de cunho bibliográfica. Para fundamentar o texto, amparamo-nos em: Pimenta e Lima (2017); Colombo; Ballão, (2014); Carvalho (2012); Freire (2018, 2011); Gatti (2019). A pesquisa aponta que é necessário a apropriação dos conhecimentos históricos, legais e teóricos sobre o estágio supervisionado, e ainda que, este necessita de que teoria e prática estejam lado a lado para ampliar a formação. Não existe verticalização nesse processo, mas sim relações em que tanto a teoria quanto a prática possuem funções a desempenhar para a ampliação e consolidação dos conhecimentos e relações educacionais.
INFLUENCE OF CONFIGURATION OF THE ELECTRODE SYSTEM OF A COAXIAL MAGNETO PLASMA ACCELERATOR ON ARC DISCHARGE FORMATION AND DEVELOPMENT
Authors: Tsimmerman Alexander I. , Shanenkov Ivan I. , Nassyrbayev Artur R. , Nikitin Dmitry S. , Sivkov Alexander A.
Published: August 2023

Link for citation: Tsimmerman A.I., Shanenkov I.I., Nassyrbayev A.R., Nikitin D.S., Sivkov A.A. Influence of configuration of the electrode system of a coaxial magneto plasma accelerator on arc discharge formation and development. Bulletin of the Tomsk Polytechnic University. Geo Аssets Engineering, 2023, vol. 334, no. 8, рр. 39-50. In Rus.
The relevance of the research is explained by a wide range of practical areas, where various plasma generators can be used, including analytical devices, technological installations, tokamaks, ion and plasma engines, satellites, laser technology, as well as by the possibility of applying them for both producing coatings on various surfaces and synthesizing fine and nanopowders. The main aim of the research is to determine the best way to initiate an arc discharge in the acceleration channel of the coaxial magnetoplasma accelerator, to estimate the effect of the plasma formation zone configuration on the electrodynamic loads of the accelerator, and to calculate the efficiency of conversion of stored energy to supplied one. Objects: coaxial magnetoplasma accelerator, arc discharge initiation, central electrode, electrode-barrel, plasma formation zone. Methods: experiment, plasma dynamic synthesis, measurement and registration of pulsed currents and voltages, electrical erosion measurement by means of weighing the eroding electrode-bore, high-speed photoregistration of the plasma jet. Results. Two methods of arc discharge initiation using metal wires and graphitization were considered. It is established that they do not affect the energy parameters of the plasma dynamic synthesis, but the graphitization looks preferable due to the greater processability of the procedure that provides easy accelerator preparation and reliability of its operation. The possibility of reducing the arc discharge current amplitude by 29 % with increasing the plasma formation zone length from 5,5 to 11,5 mm was established that results in reducing electrodynamic loads on all system nodes. The optimal plasma formation zone length of 9,5 mm was determined to provide obtaining a high efficiency of conversion of stored energy into supplied energy and reliability of the system operation.
Bibliometric Analysis of Studies on Refugee/Immigrant/Asylum Seeker Students
Authors: USTA Mehmet Emin , DOĞAN Ümit
Published: August 2023

The aim of the study was to examine the studies published on the concept of refugee/immigrant/refugee student in terms of their bibliometric characteristics. The research was carried out in the descriptive survey model. In the study, the bibliometric method was used to examine the publication outputs and the basic structure of the field. As a result of the data from the Web of Science (WoS) database on refugee/immigrant/refugee student, 497 studies were analyzed. Within the scope of the research, descriptive statistics for the descriptive structure of the refugee/immigrant/refugee student concept, analyzes showing the distribution of publications by country, descriptive statistics of influential authors, articles and journals, co-author analyzes to reveal the social structure of the literature on the concept of refugee/immigrant/refugee student. In order to reveal the conceptual structure, trend topic analyzes, strategic diagram and word cloud analyzes were used. As a result of the research, while not much research was done between 1980 and 2008, it was determined that there was a rapid increase in the number of studies as of 2009. As a result of the research, it was concluded that the United States of America is the country that publishes the most on refugee/immigrant/asylum-seeking students. It has been concluded that the research conducted by Refugee/immigrant/asylum-seeking students in schools has the most references.
Reinforcement learning methods for network-based transfer parameter selection
Authors: Guo Yue , Wang Yu , Yang I-Hsuan , Sycara Katia
Published: August 2023

A significant challenge in self-driving technology involves the domain-specific training of prediction models on intentions of other surrounding vehicles. Separately processing domain-specific models requires substantial human resources, time, and equipment for data collection and training. For instance, substantial difficulties arise when directly applying a prediction model developed with data from China to the United States market due to complex factors such as differing driving behaviors and traffic rules. The emergence of transfer learning seems to offer solutions, enabling the reuse of models and data to enhance prediction efficiency across international markets. However, many transfer learning methods require a comparison between source and target data domains to determine what can be transferred, a process that can often be legally restricted. A specialized area of transfer learning, known as network-based transfer, could potentially provide a solution. This approach involves pre-training and fine-tuning "student" models using selected parameters from a "teacher" model. However, as networks typically have a large number of parameters, it raises questions about the most efficient methods for parameter selection to optimize transfer learning. An automatic parameter selector through reinforcement learning has been developed in this paper, named "Automatic Transfer Selector via Reinforcement Learning". This technique enhances the efficiency of parameter selection for transfer prediction between international self-driving markets, in contrast to manual methods. With this innovative approach, technicians are relieved from the labor-intensive task of testing each parameter combination, or enduring lengthy training periods to evaluate the impact of prediction transfer. Experiments have been conducted using a temporal convolutional neural network fully trained with the data from the Chinese market and one month's US data, focusing on improving the training efficiency of specific driving scenarios in the US. Results show that the proposed approach significantly improves the prediction transfer process.
Using interpretive structural modelling and quality cost model to solve project completion delay in shipyard case study in PT X
Authors: Susilawati Ngurah Ayu Happy , Adhariani Desi
Published: August 2023

Purpose – This research proposes an alternative method to solve completion delay issue and optimized the strategy using ISM technical method and Quality Cost Model application.
Design/methodology/approach – Data was acquired from 120 questions from company key persons that involved in project for last 5 years. The instruments processed using ISM analysis to measure the relationship among causes, then using Quality Cost Model to solve.
Findings – This research shows that factors of late payment from client, delays in bank credit processing, bad weather, and design changes by owners are the root causes of delays. Further analysis using the Theory of Constraint (TOC) shows that financial constraint issues influence the decreased throughput and increase operating cost. Further management use five sequential steps to improve the management and P-A-F models as one of strategic cost management tools applied to the root causes to determine the optimum cost strategy to solve the problem.
Research limitations/implications – This research was conducted using a case study method, and the conclusion related to problem and root cause may not be applied totally to other companies, but the framework may be applicable. Future research can investigate other issue using TOC framework, combine TOC with other models to conduct root cause analysis, and the COQ model implementation in shipyard management.
Practical implications – This research demonstrates that management can use Interpretative Structural Modelling (ISM) analysis to determine the root cause, then analyse and overcome the issues using TOC framework. COQ model approach to sharpening the decision, and prioritize the resources allocation.
Originality/value – This research combine ISM, TOC, and PAF Quality Cost Model approach for decision making which can be a management tool in strategic cost management.
Feasibility of Using Gag Proteins to Reawaken Dormant HIV Infection Based on Bioinformatics Analysis
Authors: Chen S.
Published: August 2023

Recent studies revealing varied responses of infected cells to LRAs underscore the limited effectiveness of these agents and emphasize the wide array of determinants contributing to the heterogeneity of reservoirs, including virus genetic background, cell model, cell type, silencing mechanisms, tissue reservoirs, integration sites, patient, and gender specific factors. The enhancer region of the HIV-1 LTR contains two adjacent NF-κB binding sites that play a central role in mediating inducible HIV-1 gene expression. Beyond the involvement of various transcription factors, such as NF-κB, epigenetic constraints also play a pivotal role in suppressing the initiation of latent HIV transcription. Consequently, even latent viruses containing functional NF-κB sites remain unresponsive to drugs that activate NF-κB. Thus, it is evident that the activation of NF-κB alone does not suffice to trigger latent HIV, contradicting the central hypothesis of this study. The author used bioinformatics methods to analyze the viral proteins and their primer binding sites. The results show that the amino acid sequence ARG of Gag proteins of HTLV-1, HTLV-2, STLV-1 and STLV-2 match their primer binding site GGGGGCTCG in the 3'-to-5' direction and that the amino acid sequence SPR of Gag proteins of HIV-1, HIV-2, SIV and FIV match their primer binding site GGCGCCCGA in the 3'-to-5' direction. Related studies have shown that the genomic Gag/Gag-Pol complex recruits the LysRS/tRNA complex. The selective packaging of the tRNA primer requires HIV-1 Gag and Gag-Pol, and an interaction between LysRS and Gag is observed in vitro. In HIV-1, Gag/LysRS interaction depends on Gag sequences within the CTD of CA around amino acids 283-363 and motif 1 of LysRS around amino acids 208-259. It should be noted that the amino acid sequence SPR of the Gag protein is located at amino acids 148-150 within the NTD of CA, specifically at the NTD-NTD interface 1. Although this research is purely bioinformatics analysis, the relevant studies have demonstrated that Gag proteins match the HIV-1 primer binding site and possess the potential to directly activate dormant retroviruses.
The Predicate of the Current Mathematical Knowledge Substantially Increases the Constructive and Informal Mathematics and Why It Cannot Be Adapted to Any Empirical Science
Authors: Tyszka Apoloniusz
Published: August 2023

We assume that the current mathematical knowledge K is a finite set of statements which is time-dependent. This set exists only theoretically. In every branch of mathematics, the set of all knowable truths is the set of all theorems. This set exists independently of K. We explain the distinction between algorithms whose existence is provable in ZFC and constructively defined algorithms which are currently known. By using this distinction, we obtain non-trivial statements on decidable sets X⊆N that belong to constructive and informal mathematics and refer to the current mathematical knowledge on X. This and the next sentence justify the article title. For any empirical science, we can identify the current knowledge with that science because truths from the empirical sciences are not necessary truths but working models of truth from a particular context. Some subsets of K lead our attention to concrete finite sets. Among them is the set {k∈N\{0}: it is proved that k!+1 is prime} on which is based our main statement.
Understanding the Effect of Different Glucose Concentrations in the Oligotrophic Bacterium Bacillus subtilis BS-G1 through Transcriptomics Analysis
Authors: Chen Liping , Wang Chenglong , Su Jianyu
Published: August 2023

Glucose is an important carbon sources for microbial growth, and its content in infertile soils is essential for the growth of the bacterium. Since the mechanism of oligotrophic bacterium adaptation in barren soils is unclear, the research employed RNA Seq technology to examine the impact of glucose concentration on the low nutrient bacteria BS-G1 in soil affected by desertification. RNA-Seq revealed that differentially expressed genes（DEG）histidine metabolism, glutamate synthesis, HIF-1 signalling pathway, sporulation, and TCA cycle pathway of BS-G1 were significantly enriched in 0.015 g/L glucose concentration, compared with 10 g/L glucose concentration. DEG amino acids system, two-component system, Metal Ion Transport, and nitrogen metabolism system of B. subtilis BS-G1 were significantly enriched in 5 g/L glucose concentration, compared with 10 g/L glucose concentration. In addition, The present study identified its regulation pattern and key genes under the low glucose environment (7 mRNAs, 16 sRNAs). This study primarily investigates the variances in the regulatory pathways of oligotrophic bacteria BS-G1, which holds substantial importance in comprehending the mechanism underlying the limited sugar tolerance of oligotrophic bacteria.
A Novel Diagnostic Signature of Activated NK-Associated Genes for Ulcerative Colitis: Based on Bulk and ScRNA-Seq Data
Authors: Dong Siyuan , Zhang Yu , Ye Lingna , Cao Qian
Published: August 2023

Natural killer cells are associated with the pathogenesis of ulcerative colitis (UC), but their precise contributions remain unclear. The present study sought to investigate the diagnostic value of activated NK-associated genes (ANAGs) in UC. Bulk RNA-seq and scRNA-seq datasets were obtained from the Gene Expression Omnibus (GEO) and Single Cell Portal (SCP) databases. In the bulk RNA-seq, 92 differentially expressed genes (DEGs) were screened out by the “Batch correction” and “Robust rank aggregation” (RRA) methods. The immune infiltration landscape was estimated by single-sample gene set enrichment analysis (ssGSEA) and CIBERSORT, which revealed a higher abundance of activated NK cells in noninflamed UC tissues. 54 DEGs correlated with activated NK cells were identified as ANAGs. Protein-protein interaction (PPI) analysis and least absolute shrinkage and selection operator (LASSO) regression were utilized to screen out 4 key ANAGs (SELP, TIMP1, MMP7, and ABCG2) and establish an activated NK-associated gene score (ANAG score). The ANAG score demonstrated excellent diagnostic value and was validated in three external datasets. The expression of the 4 key ANAGs was validated in UC patients and healthy controls (HC) samples. Through scRNA-seq data analysis, higher expression levels of SELP, TIMP1, MMP7, and ABCG2 were observed in post-capillary venules, inflammatory fibroblasts, enterocytes, and immature enterocytes. The cell scores based on the ANAGs showed enrichment in endothelial cells and fibroblasts. In conclusion, we established and validated an ANAG score with the ability to precisely diagnose UC. The 4 key ANAGs have the potential to serve as therapeutic targets in UC.
Applicability of Transition State Theory to the (Proton-Coupled) Electron Transfer in Photosynthetic Water Oxidation with Emphasis on the Entropy of Activation
Authors: Dau Holger , Greife Paul
Published: August 2023

Recent advancements in the study of the protein complex photosystem II have clarified the sequence of events leading to the formation of oxygen during the S3->S4->S0 tran-sition, wherein the inorganic Mn4Ca(µ-O)6(OHx)4 cluster finishes photo-catalyzing the water splitting reaction (Greife et al, Nature 2023, 617, 623-628; Bhowmick et al, Nature 2023, 617, 629-636) . During this final step a tyrosine radical (TyrZ), stable for a couple of milliseconds, oxidizes a cluster bound oxygen while the hydrogen bonding patterns of nearby waters shift a proton away. A treatment of this redox reaction within the context of accepted transition state theories predicts rate constants that are significantly higher than experimentally recovered values (10^12s^-1 versus 10^3s^-1). In an effort to understand this disparity, temperature dependent experiments have revealed large entropic con-tributions to the rates with only a moderate energy of activation. We suggest that the entropic source may be related to the observed proton rearrangements, and further possible near isoenergetic variations in the nearby extended h-bonding network de-laying the realization of an ‘ideal’ transition state. In the following we explore this re-lation in the context of Eyring’s transition state theory and Marcus’ electron transfer theory, and evaluate their compatibility with the experimental evidence.