bluuebunny/crossref_metadata_2025 huggingface dataset:
Structural Performance of Old Composite Floors Made up of Wrought Iron Joists and Masonry Vaults
Authors: Gattesco Natalino , Macorini Lorenzo
Published: October 2015

In this paper the behaviour of old floors made up of wrought iron beams supporting shallow masonry vaults is analysed. The performance of this structural system, which was extensively used in Europe in the XIX century, has been only marginally investigated thus far. Very few studies on masonry-iron composite floors are available in the literature, where the role played by the physical interaction between the vaults and the metallic profiles has yet to be fully understood. When assessing historical buildings with floors characterised by the analysed floor system, a realistic estimate of this interaction may be critical to avoid unnecessary and costly strengthening works. The floor structure with composite wrought iron beams and solid brick vaults of the “Military Hospital” in Trieste built in 1840 by the Hapsburg Military Administration have been investigated performing physical experiments and numerical simulations. Experimental tests were carried on the floor and used to calibrate finite element numerical descriptions. These have been adopted in numerical simulations to investigate the response of the analysed floor system up to collapse considering different geometrical characteristics for the floor. The numerical results shed some light on the actual interaction between the different components of the composite floor which significantly influences the floor stiffness and load bearing capacity.
Research of Prospective Materials for Military Protective Structures
Authors: Rolc Stanislav , Křesťan Jan , Kopkáně Daniel , Štoller Jiří , Manas Pavel
Published: October 2015

Different types of composite materials with potential application in ballistic protection of static objects are discussed and compared in present study. The studied solutions include: 1) the concretes with or without reinforcement, 2) the metallic boxes with internal gap filled with different materials and 3) the ceramics-metallic composite armours. Besides the ballistic resistance, the areal weight and the price are taken into account. The weight of solutions is important in case of static objects mainly from logistic point of view. The proposals of ballistic compositions presented in the study can facilitate the choice of solutions according to specific requests.
On Computer Processing of Safety and Health Plans in the Construction Industry
Authors: Jarský Čeněk , Gacho Pavol
Published: October 2015

This paper presents design solutions to occupational safety and health agenda (OSH) using a computer directly. It connects this agenda directly to the automated construction technology design and to the process of construction planning. It describes the first results the authors obtained as well as the draft register of occupational safety and health risks and their database that shall be used for automated production of OSH plans. Furthermore this paper describes a draft program for the creation of plans and schedules of OSH risk inspections, a program for OHS inspections and operational records of them as they are carried out. All this is in direct relation to a computer system for construction technology designing that is used in order to model building construction via implementing the construction technology network diagram method.
Different Approaches to Determine of the Explosion Effect, of a Homemade Explosive, on the Structure
Authors: Figuli Lucia , Zvaková Zuzana
Published: October 2015

With the increase in acts of terrorism, the effects of the explosion on structures has become highly topical. The aim of the paper is an analysis of various approaches to determine the response of blast loaded reinforced concrete pillar. Homemade ANFO (Ammonium nitrate + fuel oil) explosive will be a reference explosive. Such type of explosives is the most used one in terroristic attacks. The paper will be focused on the analysis of the blast wave, based on the experimental tests, and dynamic analysis of a structure under such load.
Self-Compacting Concrete Formulation by Measuring Excess Paste Volume
Authors: Mebrouki Abdelkader , Bouhamou Nasr Eddine , Mostefa Fouzia
Published: October 2015

Concrete is composed of a liquid phase (paste) and of a solid phase (aggregates with fixed gravel/sand ratio), the concrete self-compacting properties come necessarily from those of the paste. The present research is the continuity of a first phase of the testing already conducted, which resulted in obtaining an optimal self-compacting cement paste composition. This paste will be used to prepare a self-compacting concrete (SCC), while passing from the scale of the cement paste to that of the concrete, by injecting wet aggregate to the self-compacting paste. The excess paste theory was used to determine the thickness of the paste coating each aggregate with a given diameter of constituting granular skeleton, then generalized for the determination of the quantity of total paste allowing the flow of the concrete by decreasing frictions between the grains of its granular skeleton. This approach was also experimentally validated. The influence of the granular distribution was minimized by the use of the approach based on the determination of the average diameter of the aggregates. This required the determination of a homothetic factor “K” similar for all concretes with different aggregate grading. Formulation of a self-compacting concrete passes initially by the determination of a sufficient quantity of paste allowing its flow without frictions between its aggregates and to balance the mixture by the quantity of water retained by the aggregates. The self-compacting concrete characteristics would come from those of the cement paste which composes it.
Construction Materials and Green Building Certification
Authors: Giama Efrosini , Papadopoulos Agis M.
Published: October 2015

Sustainable building management is a complex problem which needs effective, adequate and suitable assessment tools and methods to address issues of incommensurability and complexity, always considering the prevailing environmental policies and legislation. Within the frame of this paper, green certifications building schemes have been described, compared to each other and evaluated, against the background of the standards provided by the International Organization for Standardization. Emphasis have been placed on information referring to construction materials environmental evaluation based on the Life Cycle Analysis methodology and the role of construction materials selection to green building certification schemes. Finally, the impact of green certification schemes on the construction market, mainly as a tool of energy management, has also been examined in relation to the absence of mandatory international standardization in sustainable building management.
Androgen deprivation therapy (castration therapy) and pedophilia: What’s new
Authors: Silvani Mauro , Mondaini Nicola , Zucchi Alessandro
Published: October 2015

Andrology is a constantly evolving discipline, embracing social problems like pedophilia and its pharmacological treatment. With regard to chemical castration, the andrologist may perform an important role as part of a team of specialists. At present, no knowledge is available regarding hormonal, chromosomal or genetic alterations involved in pedophilia. International legislation primarily aims to defend childhood, but does not provide for compulsory treatment. We reviewed international literature that, at present, only comprises a few reports on research concerning androgen deprivation. Most of these refer to the use of leuprolide acetate, rather than medroxyprogesterone and cyproterone acetate, which present a larger number of side effects. Current opinions on chemical castration for pedophilia are discordant. Some surveys confirm that therapy reduces sexual thoughts and fantasies, especially in recidivism. On the other hand, some authors report that chemical castration does not modify the pedophile’s personality. In our opinion, once existing legislation has changed, andrologists could play a significant role in the selection of patients to receive androgen deprivation therapy, due in part to their knowledge about its action and side effects.
Clinical significance of prostatic-urethral angulation on the treatment outcome of patients with symptomatic benign prostatic hyperplasia treated with tamsulosin hydrochloride
Authors: El-Tatawy Hassan , Gameel Tarek , El-enen Mohammed Abo , Hagras Ayman , Mousa Ayman , El-Bahnasy Abdel Hamid , Raheem Ali Abdel , Abu-dewan Khaled
Published: October 2015

Objectives: To evaluate the impact of the prostatic-urethral angulation (PUA) on the treatment efficacy of selective alpha-1A receptor blocker in male patients with lower urinary tract symptoms secondary to benign prostatic hyperplasia (LUTS/BPH). Materials and methods: A total of 80 patients with LUTS/BPH and with mean age 53.3 ± 6.3 (range 47-70) were included in our prospective comparative study. The patients were classified into 2 groups as a consecutive cases 40 in each one depending on the PUA either ≤ 35° (group A) or > 35° (group B). PUA and different prostatic parameters were measured using transrectal ultrasound. Prostate-specific antigen (PSA), the International Prostate Symptom Score and quality of life score (IPSS/QoL score), maximum flow rate (Qmax), and postvoid residual (PVR) volume were compared between the groups. The clinical significance of PUA was evaluated after 8 weeks of medical treatment with tamsulosin hydrochloride 0.4 mg daily. Results: Baseline evaluation (pre-treatment) for both groups were comparable to each other with no clinically significant difference regarding age, PSA, IPSS/QoL score, Qmax and PVR volume (P-value > 0.05). Comparison of parameters after 8 weeks showed that tamsulosin hydrochloride improved the total IPSS and all subscores (P < 0.001), QoL (P = 0.001), Qmax (P = 0.002), and PVR (P = 0.04) in group A (Table 1). Conclusion: Tamsulosin hydrochloride appears to be less effective in improving IPSS/Qol score, Qmax and PVR in patients with lager PUA. The PUA might be a predictor for the treatment efficacy of α-blockers and more studies are warranted in the future before the final conclusion.
Sex-related penile fracture with complete urethral rupture: A case report and review of the literature
Authors: Garofalo Marco , Bianchi Lorenzo , Gentile Giorgio , Borghesi Marco , Vagnoni Valerio , Dababneh Hussam , Schiavina Riccardo , Franceschelli Alessandro , Romagnoli Daniele , Colombo Fulvio , Corcioni Beniamino , Golfieri Rita , Brunocilla Eugenio
Published: October 2015

Objective: To present the management of a patient with partial disruption of both cavernosal bodies and complete urethral rupture and to propose a non-systematic review of literature about complete urethral rupture. Material and method - Case report: A 46 years old man presented to our emergency department after a blunt injury of the penis during sexual intercourse. On physical examination there was subcutaneous hematoma extending over the proximal penile shaft with a dorsal-left sided deviation of the penis and urethral bleeding. Ultrasound investigation showed an hematoma in the ventral shaft of the penis with a discontinuity of the tunica albuginea of the right cavernosal corporum. The patient underwent immediate emergency surgery consisted on evacuation of the hematoma, reparation the partial defect of both two cavernosal bodies and end to end suture of the urethra that resulted completely disrupted. Results: The urethral catheter was removed at the 12-th postoperative day without voiding symptoms after a retrograde urethrography. 6 months postoperatively the patients was evaluated with uroflowmetry demonstrating a max flow rate of 22 ml/s and optimal functional outcomes evaluated with validated questionnaires. 8 months after surgery the patients was evaluated by dynamic magnetic resonance (MRI) of the penis showing only a little curvature on the left side of the penile shaft. Conclusion: Penile fracture is an extremely uncommon urologic injury with approximately 1331 reported cases in the literature till the years 2001. To best of our knowledge from 2001 up today, 1839 more cases have been reported, only in 159 of them anterior urethral rupture was associated and in only 22 cases a complete urethral rupture was described. In our opinion, in order to prevent long term complications, in case of clinical suspicion of penile fracture, especially if it is associated to urethral disruption, emergency surgery should be the first choice of treatment.
Three-dimensional apoptotic nuclear behavior analyzed by means of Field Emission in Lens Scanning Electron Microscope
Authors: Salucci S. , Burattini S. , Falcieri E. , Gobbi P.
Published: October 2015

Apoptosis is an essential biological function required during embryogenesis, tissue homeostasis, organ development and immune system regulation. It is an active cell death pathway involved in a variety of pathological conditions. During this process cytoskeletal proteins appear damaged and undergo an enzymatic disassembling, leading to formation of apoptotic features. This study was designed to examine the three-dimensional chromatin behavior and cytoskeleton involvement, in particular actin re-modeling. HL-60 cells, exposed to hyperthermia, a known apoptotic trigger, were examined by means of a Field Emission in Lens Scanning Electron Microscope (FEISEM). Ultrastructural observations revealed in treated cells the presence of apoptotic patterns after hyperthermia trigger. In particular, three-dimensional apoptotic chromatin rearrangements appeared involving the translocation of filamentous actin from cytoplasm to the nucleus. FEISEM immunogold techniques showed actin labeling and its precise three-dimensional localization in the diffuse chromatin, well separated from the condensed one. The actin presence in dispersed chromatin inside the apoptotic nucleus can be considered an important feature, indispensable to permit the apoptotic machinery evolution.
An in situ hybridization study of perlecan, DMP1, and MEPE in developing condylar cartilage of the fetal mouse mandible and limb bud cartilage
Authors: Fujikawa K. , Yokohama-Tamaki T. , Morita T. , Baba O. , Qin C. , Shibata S.
Published: October 2015

The main purpose of this in situ hybridization study was to investigate mRNA expression of three bone/cartilage matrix components (perlecan, DMP1, and MEPE) in developing primary (tibial) and secondary (condylar) cartilage. Perlecan mRNA expression was first detected in newly formed chondrocytes in tibial cartilage at E13.0, but this expression decreased in hypertrophic chondrocytes at E14.0. In contrast, at E15.0, perlecan mRNA was first detected in the newly formed chondrocytes of condylar cartilage; these chondrocytes had characteristics of hypertrophic chondrocytes, which confirmed the previous observation that progenitor cells of developing secondary cartilage rapidly differentiate into hypertrophic chondrocytes. DMP1 mRNA was detected in many chondrocytes within the lower hypertrophic cell zone in tibial cartilage at E14.0. In contrast, DMP1 mRNA expression was only transiently detected in a few chondrocytes of condylar cartilage at E15.0. Thus, DMP1 may be less important in the developing condylar cartilage than in the tibial cartilage. Another purpose of this study was to test the hypothesis that MEPE may be a useful marker molecule for cartilage. MEPE mRNA was not detected in any chondrocytes in either tibial or condylar cartilage; however, MEPE immunoreactivity was detected throughout the cartilage matrix. Western immunoblot analysis demonstrated that MEPE antibody recognized two bands, one of 67 kDa and another of 59 kDa, in cartilage-derived samples. Thus MEPE protein may gradually accumulate in the cartilage, even though mRNA expression levels were below the limits of detection of in situ hybridization. Ultimately, we could not designate MEPE as a marker molecule for cartilage, and would modify our original hypothesis.
Primary chest wall lymphoma
Authors: Shah Binay Kumar
Published: October 2015

Primary chest wall lymphoma is a rare but curable condition. This paper reports a case of a 52-year-old female patient who presented with a primary chest wall diffuse large B-cell lymphoma.
Malignant phyllodes tumor with heterologous differentiation
Authors: Okaly Geeta V. Patil , Devadass Clement Wilfred , Metikurke Sudha Horakerappa
Published: October 2015

Sarcomas of the breast are rare neoplasms accounting for less than 1% of breast malignancy. A 40-year-old-female with left breast mass underwent wide-excision and on histopathological examination a diagnosis of malignant phyllodes tumor with heterologous differentiation of osteosarcoma and chondrosarcoma was rendered. The heterologous elements were tumor osteoid formation and tumor chondroid formation. The rarity of the lesion was considered for reporting and on follow-up the patient was free of metastasis.
Esophageal resection for giant leiomyoma
Authors: Gupta Vikas , Sinha Saroj K. , Vaiphei Kim , Lal Anupam
Published: October 2015

A 55-year-old Indian female presented with chest discomfort at swallowing and occasional dyspnea. Esophagogastroduodenoscopy revealed an extramucosal mass in the upper and mid esophagus. Computerized tomogram visualized a mass 7 × 11 cm in diameter in the middle esophagus with eccentric lumen and tracheal compression. Transthoracic esophagectomy was performed. She made an uneventful recovery. Diagnosis of leiomyoma was established on histopathology and immunohistochemistry staining.
Recurrent malignant sino-nasal solitary fibrous tumor
Authors: Roy Soumyajit , Mallick Supriya , Kakkar Anchal , Jana Manisha , Julka Pramod Kumar
Published: October 2015

Solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms that usually arise in the pleura or less commonly in relation to other serosal surfaces. Infrequent case reports of extra-pleural SFTs have been described at various sub sites within the head and neck area. We report a case of recurrent sino-nasal SFTs treated with surgery followed by re-excision and adjuvant radiation on recurrence and then salvage chemotherapy on progression. Further discussed are the challenges associated with accurate histological and immunohistochemical diagnosis, the difficulty in assessing the aggressiveness and malignant potential of these lesions and the appropriate treatment and follow-up duration that these neoplasms require. To the best of our knowledge this is the first reported case of recurrent malignant sino-nasal SFT in available scientific literature in English language.
Pilomyxoid astrocytoma in an adult woman
Authors: Kibola Adam H. , McClelland Shearwood , Hlavin Joseph , Friedman Jonathan A.
Published: October 2015

Pilomyxoid astrocytoma (PMA) is a recently classified WHO grade II astrocytoma that is histologically similar to pilocytic astrocytoma (PA). Both tumors typically present in childhood, but PMA is more aggressive with higher rates of recurrence and cerebrospinal fluid dissemination. Currently, there is no standardized treatment protocol for PMA although this will change with increased awareness of this disease entity within the neurosurgical community. We present a 22-year-old patient with a left frontal lobe PMA manifesting with atypical radiographic findings. This is the first reported case of PMA in an adult woman.
Rhabdomyosarcoma of vulva in a young lady
Authors: Bhattacharyya Tapesh , Patel Firuza D. , Srinivasan Radhika , Rai Bhavana , Saha Pradeep , Nijhawan R.
Published: October 2015

A 21-year-old lady presented with a rapidly progressive vulvar swelling with inguinal lymphadenopathy for 7 months. Pathological evaluation revealed it as a case of rhabdomyosarcoma. The disease behaved aggressively and she was treated with multimodality treatment.
A solitary fibrous tumor of the kidney
Authors: Abeygunasekera Anuruddha M. , Ginige Anusha P. , Liyanage Indika S. H. , Hareendra Kalana
Published: October 2015

A solitary fibrous tumor (SFT) is an uncommon spindle cell neoplasm that usually occurs in the pleura, but may occur in extrapleural sites. Its occurrence in the kidney is rare. We report a SFT, clinically thought to be a renal cell carcinoma arising in the kidney of a 68-year-old female. The tumor was well-circumscribed and composed of a mixture of spindle cells and dense collagenous bands. Immunohistochemical studies revealed reactivity for CD34, CD99, and Bcl-2 protein, with no staining for keratin or muscle markers, confirming the diagnosis. The immunohistochemical study was the key to diagnosis. Several younger members of her family had colorectal and lung cancers suggesting the possibility of a familial or genetic susceptibility.
Giant cell variant of malignant fibrous histiocytoma of male breast
Authors: Harsh Kamlesh Kumar , Kalwar Ashok , Kapoor Akhil , Jakhar Shankar Lal , Kumar Harvindra Singh
Published: October 2015

Malignant fibrous histiocytoma (MFH) is the most common form of soft tissue sarcoma during middle and late adulthood in the deep connective tissue of the extremities, abdominal cavity, and retroperitoneum. However, primary breast sarcoma is a rare disease entity, comprising less than 1% of all breast malignancies. MFH of the male breast is very rare. We present a case of MFH of giant cell variant of the right breast in a 50-year-old male who presented with a painless lump. Following cytological investigation, simple mastectomy was performed. Immunohistochemical staining confirmed the diagnosis.
Single organ variant of polyarteritis nodosa in epididymis
Authors: Garg Ketan , Dawson Leelavathi
Published: October 2015

Polyarteritis nodosa (PAN) is a systemic necrotizing vasculitis that typically affects medium-sized muscular arteries, with occasional involvement of small muscular arteries. Unlike some other vasculitides (e.g. microscopic polyarteritis, Wegener′s granulomatosis) PAN is not associated with antineutrophil cytoplasmic antibodies. Patients typically present with systemic symptoms such as fever, weight loss, and malaise. The kidneys, skin, joints, muscles, nerves, and gastrointestinal tract are commonly involved, usually in some combination. PAN can affect any organ, but usually spare the lungs. Clinical variants or subsets of PAN include single-organ disease and cutaneous-only PAN. Scrotal involvement is rarely the first presenting sign. We herein report a case of 36-year-old man who presented with a swelling in the left epididymis, which was surgically removed. The swelling histopathologically showed necrotizing inflammation, fibrinoid necrosis of the medium-sized arteries of the epididymis and was diagnosed to be single organ variant of PAN.
A case report of peritoneal malignant mesothelioma presenting as primary ovarian mass
Authors: Kapoor Rakesh , Kuttikat Philip George , Vaiphei Kim , Rai Bhavana , Patel Firuza Darius
Published: October 2015

Malignant mesotheliomas are aggressive neoplasms arising from mesothelial cells lining the body cavities. Malignant peritoneal mesothelioma (MPM) account for about one-third of the cases. Though the ovarian involvement may be seen in the background of a diffuse peritoneal involvement, the presentation of MPM as a primary ovarian mass is rare. Here we present such a case who underwent surgery but had residual progressive lesion. She received further chemotherapy resulting in a complete response and is disease free for almost a year.
Neuroendocrine carcinoma of the tongue
Authors: Esmati Ebrahim , Babaei Mohammad , Matini Amirhassan , Ashtiani Monir Sadat Mirai , Hamed Ehsan Akbari , Nosrati Hassan , Razi Farideh , Ganjalikhani Maryam
Published: October 2015

Neuroendocrine carcinoma usually originates from lung. Few data exist in the literature regarding neuroendocrine carcinoma of the tongue. Patient data including history, surgical procedure, histology, and radiology investigations were collected and summarized. A 40-year-old woman was referred after partial glossectomy. Squamous mucosa with neoplasm and cells with round nuclei and light cytoplasm was reported in the tongue biopsy. Immunohistochemistry (IHC) staining was positive for cytokeratin, neuron specific enolase, synaptophysin and chromogranin and negative for leukocyte common antigen. This case showed a high proliferative activity (Ki-67 labeling index were 60%). These IHC findings were in favor of poorly differentiated neuroendocrine carcinoma. After surgery, she received chemotherapy and chemoradiation. The diagnosis of neuroendocrine tumors in the present case is based on immunohistochemical markers and cellular shapes. Postoperative chemoradiotherapy is a critical element of therapy for head and neck high-grade neuroendocrine carcinomas, our patient received this treatment after surgery.
Cervical embryonal rhabdomyosarcoma and ovarian Sertoli-Leydig cell tumor with congenital absence of unilateral ovary
Authors: Sunku Rubu , Duggal Rajan , Patel Firuza D. , Rai Bhavana , Srinivasan Radhika , Nijhawan Raje
Published: October 2015

We report this first case of synchronous cervical rhabdomyosarcoma and Sertoli-Leydig cell tumor (SLCT) of ovary with congenital absence of unilateral ovary and fallopian tube in a 16-year-old female patient. A review of the English-language literature identified only six cases of double malignancies with cervical rhabdomyosarcoma and SLCT but none of the case was associated with congenital absence of ovary and fallopian tube. When such multiple conditions involving one system occur in an individual, the possibility of single etiology arises, but beside some hypothesis, no definite link could be established in any of the cases reported.
Small cell neuroendocrine carcinoma of the posterior tongue
Authors: Gumusay Ozge , Yilmaz Guldal , Aydil Utku , Ozet Ahmet , Tufan Gulnihal , Erdem Ozlem , Kizil Yusuf , Benekli Mustafa
Published: October 2015

In the head and neck mucosa, neuroendocrine carcinomas of the oral cavity is rare. Herein, we present the first report of a small cell neuroendocrine carcinoma in a 54-year-old man on the right lateral posterior tongue. It is important to remember that although neuroendocrine small cell carcinomas (SCCs) are most commonly seen in the lung, they rarely may arise in the extrapulmonary sites, including salivary glands, as well. As there is not any standard therapeutic regimen already existing, it is important to be aware of and to know how to deal with such rare cases.
Multiple skin cancers in a single patient
Authors: Saini Ravi , Sharma Nidhi , Pandey Kritika , Puri K. J. P. S.
Published: October 2015

Basal cell carcinoma (BCC) and squamous cell carcinoma are the most common type of nonmelanoma skin cancers (NMSCs). Bowen′s disease (BD), a premalignant condition, has a marginal potential (3-5%) to progress to invasive carcinoma. We report here a rarest of a rare case of multiple pigmented BD with overlying squamous cell cancer along with a giant neglected BCC on the scalp of a 76-year-old man. The occurrence of multiple BD and NMSC in a single patient compelled us to explore the following hypothesis: (1) The multiple precancerous and cancerous lesions can be due to common etiopathogenesis. Chronic ultraviolet exposure, immunosupresssion, human papillomavirus infection, dietary factors, and environmental factors including arsenic exposure were probed in to. (2) There is evolution of precancerous lesions into a different type of cancers in different time frame. (3) The new cancerous lesions are subsequent cancers that developed after neglected untreated primary cancer.
Simultaneous occurrence of sarcomatoid hepatocellular carcinoma and hepatocellular carcinoma
Authors: Huang Zhaoqin , Meng Xiangjiao , Liu Qingwei
Published: October 2015

Sarcomatoid hepatocellular carcinoma is a rare disease with a poor prognosis. A 62-year-old man presented with 1-month history of middle-grade fever and fatigue in the background of loss of weight and a history of hepatitis B for 10 years. Dynamic contrast enhanced computed tomography showed two distinct irregular hypodense masses on precontrast scan located in hepatic segment VI and VII with size 6.7 × 4.7 × 4.5 cm and 1.9 × 1.3 × 1.6 cm. The patient underwent the right hepatectomy. Microscopic examination revealed that the large tumor was sarcomatoid hepatocellular carcinoma and the small tumor was early hepatocellular carcinoma.
Primary breast lymphoma with progression to the scalp
Authors: Arundhati  , Malhotra Kiran Preet , Husain Nuzhat
Published: October 2015

Primary lymphomas developing in the breast constitute a rare entity. A 50-year-old female presented with a breast lump for duration of 2 months. She also had a scalp swelling since 2 days. No lymph nodal involvement was present. Histopathological examination and immunohistochemistry performed on a core needle biopsy of the breast lump revealed a diffuse large B-cell non-Hodgkin′s lymphoma, an aspirate of the scalp swelling revealed progression from the primary breast lymphoma (PBL). We review the relevant literature and discuss the diagnostic aspects of extranodal lymphomas arising in the breast. Disease progression to the scalp from PBL has not been reported until date. We hereby report the first case of progression to the scalp in a case of PBL.
Histopathological, immunohistochemical and special stain unraveling the enigmatic carcinosarcoma - A case report
Authors: Shakil Moidin , Mohtesham Imran , Jose Maji
Published: October 2015

Carcinosarcoma is an extremely rare, highly malignant tumor having a characteristic of both epithelial and mesenchymal components; the epithelial component exhibiting focal squamous cell carcinoma and mesenchymal component having sarcomatoid stroma. The occurrence of carcinosarcoma in the oral cavity is very rare and only few cases have been reported in the literature, although its occurrence in other parts of the body has been widely reported.
Clinicopathological characteristics of xeroderma pigmentosum associated with keratoacanthoma in an infant
Authors: Han Xu′e , Jing Hongbiao , Liu Cuijie , Zheng Jinfeng
Published: October 2015

A rare case of xeroderma pigmentosum coexisted with keratoacanthoma in an 18-month-old boy was reported. The boy was admitted with unequal size, irregularly shaped brown spots, patches and depigmentation spots on his face. A well-circumscribed hemispherical mass measuring 3 cm × 3 cm with smooth surface and brown patches was observed beneath his left lower eyelid. Light microscopic examination of the skin lesions revealed epidermal hyperkeratosis, chronic inflammatory infiltration of the superficial dermal layer, and increases in melanocytes and melanin in the basal layer. The mass beneath the left lower eyelid was cup-shaped, consisting of proliferating squamous cells with a central keratin plug. The squamous epithelium was acanthotic with hypergranulosis. The adjacent epidermis formed exophytic projections resulting in a silhouette likened to lips. The patient was treated with a combination of antioxidant drugs, keeping the child from light and surgical excision of the mass. No recurrence has been observed.
Villous adenoma of the urinary bladder
Authors: Pal Dilip Kumar
Published: October 2015

Villous adenoma is a known entity in the gastrointestinal tract, but very rare in the urinary tract. It is a benign tumor with excellent prognosis, but its progression to adenocarcinoma is not established. Here, we report an additional case of villous adenoma of the urinary bladder.
Plasma miR-185 as a predictive biomarker for prognosis of malignant glioma
Authors: Tang Hailin , Liu Qing , Liu Xiaoping , Ye Feng , Xie Xinhua , Xie Xiaoming , Wu Minghua
Published: October 2015

Introduction:

Specific microRNA (miRNA) expression signatures have been identified in a variety of human cancers. More recently, increasing evidence shows that miRNAs exist in human blood serum and plasma.

Materials and Methods:

Levels of miR-185 in plasma were measured by quantitative reverse-transcriptase polymerase chain reaction in 66 glioma patients, 11 pituitary adenoma patients, 32 meningioma patients, and 14 acoustic neuroma patients.

Results:

The plasma levels of miR-185 were significantly altered in glioma patients compared to normal controls. However, its levels were not observably changed in patients with other brain tumors such as meningioma, acoustic neuroma, or pituitary adenoma. Furthermore, the plasma levels of miR-185 in glioblastoma multiforme patients with operation and chemo-radiation almost revived to normal levels. Finally, we also demonstrated that low plasma miR-185 levels are correlated with poor survival in glioma patients.

Conclusion:

These findings suggest that plasma miR-185 has become potential biomarkers for glioma and may be useful in clinical management for glioma patients.
Cedecea lapagei in a patient with malignancy
Authors: Biswal Indu , Hussain Nishat Ahmed , Grover R. K.
Published: October 2015

Cedecea lapagei is a member of the family Enterobacteriaceae and is an uncommon pathogen. There are very few reports of isolation of this organism from biological samples; mostly it is found to be a pathogen in elderly or otherwise medically compromised. We present a rare case of a patient with underlying malignancy of buccal mucosa, who developed an oral ulcer superinfected with C. lapagei. According to the available literature, this is the first case of C. lapagei from India detected in a cancer patient.
Retiform hemangioendothelioma over forehead
Authors: Tamhankar Anup Sunil , Vaidya Abhishek , Pai Prathamesh
Published: October 2015

Retiform hemangioendothelioma (RH) is low grade tumor of skin and subcutaneous tissue. It needs to be differentiated from angiosarcoma as RH has excellent prognosis. It is usually seen in young adults on extremities. Sometimes it may mimic benign conditions and can delay treatment. Surgery has been mainstay of its treatment with or without adjuvant radiation. We present first case of RH on face. This is only second case being treated with definitive chemoradiation. So it′s important to distinguish RH from angiosarcoma due to treatment implications as well.
Intensity modulated radiation therapy (IMRT) is not superior to three-dimensional conformal radiation (3DCRT) for adjuvant gastric radiation
Authors: Chopra Supriya , Agarwal Aditi , Engineer Reena , Dora Tapas , Thomas Biji , Sonawone Supriya , Paul Siji N. , Kannan Sadhna , Patil Prachi , Mehta Shaesta , Shrivastava Shyam Kishore
Published: October 2015

Aims:

To compare three-dimensional conformal radiation (3DCRT) and Intensity Modulated Radiation Therapy (IG-IMRT) for adjuvant gastric irradiation.

Subjects and Methods:

From Jan 2010-Aug 2013, all patients undergoing 3DCRT and IG-IMRT were included. Systemic chemotherapy included 1 cycle before and 2 cycles after chemoradiation. Planning Target Volume (PTV) received 45 Gy/25 fractions/5 weeks with concurrent capcetabine 825 mg/m2 bid. Matched pair analysis was performed to evaluate imbalance in two cohorts if any. Common Toxicity Criteria for Adverse Event (CTCAE) vs 3.0 was used to record gastrointestinal (GI), hematological (HL), and renal toxicity during treatment and follow-up. Patterns of recurrence were documented. Mann-Whitney U test was used for statistical comparison.

Results:

Of the 51 patients, 26 received 3DCRT and 25 IMRT. IMRT led to decrease in dose received by right and left kidney (12.4 Gy and 7.1 Gy and 29 Gy vs 8.2 Gy; P < 0.001). Overall, 17.6% and 19.6% patients had grade II GI and HL toxicity and 3.9% and 5.9% had grade III GI and HL toxicity. No difference was observed in acute grade II-V GI or HL toxicity (11.5% vs 24%, P = 0.07; 7.6% vs 20% P = 0.20) or late GI, HL, or renal toxicity between 3DCRT and IMRT. No difference was observed in patterns of local relapse (11.5% vs 12%, P = 0.14) or overall survival (39% and 38% (P = 0.97)) between 3DCRT and IMRT.

Conclusions:

3DCRT and IMRT are equivalent in terms of toxicity and local control.
Hyperleukocytosis, an unusual paraneoplastic manifestation of lung cancer
Authors: Sreevatsa Aparna , Babu Suresh M. C. , Babu Govind K. , Suresh T. M.
Published: October 2015

Leukocytosis may be found in patients with lung cancer either at time of diagnosis or during the course of the disease. Though mild leukocytosis is common in lung cancer, hyperleukocytosis defined as total leukocyte count more than 100,000 is uncommon. We describe a 68-year-old chronic smoker who presented with osteolytic pelvic bone lesion and hyperleukocytosis, who on evaluation was found to have a primary lung cancer. Bone marrow aspiration and biopsy showed marked myeloid hyperplasia. Myeloid series comprised predominantly mature neutrophils and stab forms. Cytogenetic investigation showed a normal chromosome set (46, XY). Repeated cultures from blood, urine, and sputum were sterile. He was started on chemotherapy but had a progressive downhill course. In patient with lung cancer, leukocytosis can be due to infection, use of corticosteroid or hematopoetic growth factors, bone marrow involvement, or paraneoplastic manifestation. Paraneoplastic leukocytosis is associated with poor prognosis and aggressive disease.
An unusual case of disseminated neuroendocrine tumor presenting with generalized lymphadenopathy
Authors: Karthik K. S. , Kini Hema , Kini Anand U. , Santosh Pooja
Published: October 2015

A 64-year-old male presented to the surgical out-patient department with multiple enlarged lymph nodes in the neck and axillae. As a routine practice in India, this patient was worked up on the lines of generalized lymphadenopathy with a provisional diagnosis of tuberculosis and lymphoma. The report of fine-needle aspiration cytology (FNAC) came as a surprise and on further work-up it turned out to be that the patient had disseminated neuroendocrine tumor from an unknown primary.
Années arrosées et années sèches au Proche-Orient : relation avec la circulation atmosphérique régionale
Authors: Traboulsi M. , Camberlin P.
Published: October 2015

Les précipitations au Proche-Orient (Liban, Syrie, Jordanie, Territoire Autonome Palestinien, Israël) sont caractérisées par une grande variabilité, que ce soit à l’échelle interannuelle ou à l’échelle mensuelle. Pour cerner et expliquer cette variabilité, trois ensembles régionaux de co-variation ont été définis en utilisant les données mensuelles de 116 stations pour la période 1960-61/1989-90. Nous avons analysé la relation entre les années exceptionnellement arrosées ou sèches et la circulation atmosphérique régionale (données de réanalyses). Les précipitations dans les trois régions apparaissent très dépendantes de l’occurrence et de la position d’un talweg en altitude à l’est de la Méditerranée.
Variabilité spatiale des températures dans le contexte du changement climatique a l’échelle du vignoble de Marlborough (Nouvelle-Zélande)
Authors: Philippe Félix , Sturman Andrew , Quenol Hervé
Published: October 2015

Ce travail a pour objectif de mettre en place une méthodologie de mesures (météorologiques et agronomiques) et de modélisation spatiale du climat adaptée aux échelles fines, afin d’étudier la variabilité spatiale du climat dans les régions viticoles dans le contexte du changement climatique. La région de Marlborough, première région productrice de vin en Nouvelle-Zélande, fait l’objet d’investigations du fait des forts enjeux associés à la pérennité de l’activité viti-vinicole au niveau local, régional et national. Une première analyse des températures sur une période récente, menée à partir de stations météorologiques du réseau national et de deux réseaux locaux d’enregistrement de la température, permet de mettre en évidence une forte variabilité spatiale des températures à une échelle régionale et surtout locale. L’attention est notamment portée sur l’occurrence des gelées ainsi que sur les valeurs de différents indices bioclimatiques utilisés en viticulture. Par la suite sont analysées les premières projections réalisées à échelle fine pour le moyen terme (2030-2049) et la fin du siècle (2080-2099), afin d’apporter des premiers éléments de réponse quant aux futurs changements climatiques à l’échelle de la région de Marlborough.
Localisation et dynamique du front de la brise de mer au Maghreb oriental
Authors: Dahech Salem , Berges Jean-Claude , Beltrando Gérard
Published: October 2015

Ce travail montre l’intérêt d’utiliser des images Meteosat Second Generation-Rapid Scan Service (MSG-RSS) prises dans le visible à une résolution temporelle très fine (5 mn) pour suivre la pénétration du front de la brise de mer près des côtes tunisiennes et libyennes. Les cumulus matérialisant le front commencent à apparaître sur le continent environ 4 heures après le lever du soleil; ils sont distinguables par un simple traitement visuel ou d’une façon numérique, ce qui a permis le calcul automatique de leurs vitesses. Ces dernières sont faibles (moins de 5 m/s). Les images satellitaires ainsi que les données des stations météorologiques fixes montrent une accélération en fin de journée du front de la brise de mer qui peut pénétrer jusqu’à environ 80 km dans les terres en Tunisie et environ 110 km à l’est de la Libye à des latitudes plus basses et non contrariées par un vent synoptique. L’extension verticale de la brise atteint environ 1000 m d’après le radiosondage de Tunis-Carthage.
Les interactions d’echelle au sein du systeme climatique : l’exemple de l’impact des phases chaudes de l’El Niño Oscillation Australe en Indonesie
Authors: Moron Vincent , Robertson Andrew W. , Qian Jian Hua (Joshua)
Published: October 2015

Cet article examine la modulation spatio-temporelle de l’impact des phases chaudes de l’El Niño Oscillation Australe sur les pluies indonésiennes. Les anomalies de pluies sont largement négatives sur la quasi-totalité de l’Indonésie au moment du démarrage de la mousson australe (septembre-novembre), qui est systématiquement retardé, particulièrement au sud de l’équateur, en liaison avec une anomalie de subsidence à grande échelle, des alizés d’ESE plus forts et/ou plus durables que la normale, et des anomalies négatives de la température de la surface océanique (TSO) au niveau des mers indonésiennes. Par contre, le signal pluviométrique au cœur de la mousson australe (décembre-mars) est spatialement très hétérogène, malgré l’anomalie de subsidence persistante à grande échelle, avec des anomalies négatives au-dessus de la plupart des mers, mais des anomalies positives sur certaines parties d’îles, ainsi que sur l’ouest de l’Indonésie. La mousson australe d’WNW est alors moins puissante qu’à l’habitude, ce qui est plutôt défavorable aux pluies, mais l’émergence d’anomalies positives de TSO au niveau des mers indonésiennes et une accentuation du cycle diurne contribuent au contraire à augmenter localement les pluies
Quels liens entre climatologie, occupation des sols et inondations dans le bassin versant de l’Yzeron (ouest Lyonnais) ? Apport de l’analyse conjointe de données hydroclimatiques et d’images satellitaires trés haute résolution
Authors: Kermadi Saïda , Braud Isabelle , Jacqueminet Christine , Branger Flora , Renard Florent , Michel Kristell
Published: October 2015

Le bassin versant de l’Yzeron, situé en périphérie immédiate de la ville de Lyon, est un bassin représentatif des bassins versants périurbains français. Il connaît, depuis les années 1970, une augmentation importante de son urbanisation. Ces dernières années, des crues importantes, entraînant des inondations à l’aval du bassin versant ont marqué les esprits, posant la question de l’impact des modifications de l’occupation des sols dans le bassin versant sur le régime des crues. Dans cet article, nous utilisons l’analyse combinée de données hydroclimatiques (pluie, température, évapotranspiration de référence - ET0, débits) et de cartes de l’occupation des sols dérivées d’images satellites SPOT à haute et très haute résolution pour aborder cette question. L’analyse des débits montre l’existence d’une évolution du régime des crues, avec une augmentation significative des crues sub-seuils pour des durées de 1,5 h, 3 h, 6 h, 12 h et 36 h sur la période 1970-2010. L’analyse de l’échantillon de crues obtenue par cette analyse débit – durée – fréquence montre que les crues les plus importantes sont plutôt liées à des épisodes ayant conduit à un cumul de pluie important (> 80 mm en quelques jours). Une corrélation significative est aussi obtenue entre débit de base et coefficient de ruissellement, ce qui montre que ces crues peuvent être associées à des écoulements sur surfaces saturées. Les évolutions du climat (pluviométrie, température, ET0) ne permettent pas d’expliquer l’augmentation des crues observées. En revanche, l’occupation des sols entre 1990 et 2008 montre une augmentation des surfaces imperméables qui passent de 15,2% de la surface totale du bassin en 1990 à 18,2% en 1999 et 22,6% en 2008. Cette évolution de l’imperméabilisation est mise en regard de l’accroissement de la population du bassin sur cette même période. Enfin, nous illustrons la réponse hydrologique du bassin versant avec deux épisodes pour lesquels le rôle de l’occupation des sols est différent. Le premier, celui du 02/12/2003 est typique d’une réponse par saturation du bassin, avec une contribution majeure des zones rurales, suite à des cumuls pluviométriques importants. Le second, celui du 09/08/2009 représente un orage d’été, très court mais avec des intensités importantes, conduisant essentiellement à une réponse rapide des zones urbaines et pour lequel l’occupation des sols joue un rôle majeur.
Evapotranspiration réelle et résistance du couvert d’une savane àLoudetia arundinacea(bassin du Kouilou, Congo-Brazzaville)
Authors: Nizinski Jerzy J. , Galat Gérard , Galat-Luong Anh , Dingkuhn Michaël , Fabre Denis
Published: October 2015

L’objectif de ce travail est d’estimer l’évapotranspiration réelle et la résistance du couvert d’une savane en utilisant la méthode du rapport de Bowen pour deux périodes contrastées, saison sèche et saison des pluies. La méthode du rapport de Bowen permet de quantifier l’évapotranspiration réelle de la savane à partir des mesures des gradients de température et d’humidité de l’air, du rayonnement net et du flux de chaleur dans le sol. Ses avantages en sont une rapidité de mise en place du dispositif de mesure, une résolution temporelle des mesures inférieure à une heure, une continuité des mesures, une bonne intégration des hétérogénéités du flux de chaleur latente d’évaporation du couvert. Ce dispositif est adapté aux recherches agro-météorologiques et éco-physiologiques faites en milieu tropical avec des équipes restreintes. La fiabilité de cette méthode a été appréciée par comparaison avec l’équation Monteith et la méthode de l’équation du bilan hydrique. Cette savane est dominée à 90% parLoudetia arundinacea(Pointe Noire, Congo). Les résultats présentés sont issus de mesures qui ont duré 24 jours, du 18 septembre au 11 octobre 1998 : (a) du 18 au 29 septembre (« saison sèche »), la rétention en eau du sol a été inférieure à 70% de la réserve à la capacité au champ (de 63 à 70% de RCC;stress hydrique sévère; T/ETP de 0,2 à 0,4); (b) du 30 septembre au 11 octobre (« saison des pluies »), la rétention en eau du sol a été de 90 à 92% de RCC;stress hydrique négligeable; T/ETP de 0,73 à 0,77). La résistance du couvert moyenne journalière issue du rapport de Bowen a été de 317 s m−1, avec 355 s m−1pour la « saison sèche » et de 279 s m−1pour la « saison des pluies ». Les valeurs de l’ETR cumulée de la savane issues du rapport de Bowen, de la méthode du bilan hydrique et de l’équation de Penman-Monteith sont respectivement de 58,6, 57,8 et 56,2 mm, avec une ETR moyenne journalière de 2,4-2,4 et 2,3 mm jour−1, l’ETR moyenne journalière étant de 2,4, 1,5 et 2,2 mm jour−1en « saison sèche » et de 2,5, 3,4 et 2,5 mm jour−1en « saison des pluies ».