bluuebunny/crossref_metadata_2025 huggingface dataset:
Introduction to Special Issue
Authors: Kim Ann H. , Buckner Elizabeth , Montsion Jean Michel
Published: November 2022

internationale critically examines where international students from Asia fit within broader initiatives of internationalization, Indigenization and decolonization, and equity, diversity, and inclusion in Canada’s colleges and universities. The goal is to contextualize some of the challenges they face, to understand how they fit within institutional priorities, and to examine knowledges, strategies, structures, and spaces from critical perspectives. The seven papers in this issue, as described in the next section, were selected for their examination and exposition of the connections and disconnections between actors in the domain of international education and for provoking questions about the lack of coherence among internationalization, Indigenization, and equity priorities within institutions. In this section, we offer a justification for the focus on students from Asia, namely India and China, and argue for situating their experiences of recruitment, exclusion, and marginalization within a decolonizing and equity, diversity, and inclusion framework.
Dealing and Collecting in Balzac’s Last Novel
Authors: Greene John
Published: November 2022

Recent studies of the reception and collection of pre-Revolutionary art in nineteenth-century France have centered on real-life historical examples and individuals such as the celebrated collector Louis La Caze. But what can the destiny of a fictional art collection tell us about the metamorphoses of the mid-nineteenth-century Parisian art market and the very essence and nature of collecting? Honoré de Balzac was an author with his own pretensions to be a great collector and this essay focuses on the complex and often contradictory representation of the art collection in Le Cousin Pons (1847)—one of the last works of La Comédie humaine to be published before the novelist’s death in August 1850.
İŞ HUKUKUNDA NAKİL KAYDI ÖZELLİĞİ DE TAŞIYAN İŞYERİ DEĞİŞİKLİĞİ DİSİPLİN CEZASI VE GENEL İŞLEM KOŞULLARI BAKIMINDAN DEĞERLENDİRİLMESİ
Authors: ALP Nihat Seyhun
Published: November 2022

İşveren, yönetim hakkına dayanarak iş görme borcunu somutlaştırmaktadır. İşçinin iş görme borcunu yerine getireceği işyeri de kural olarak yönetim hakkı kapsamında belirlenmektedir. Ancak işçinin işyeri iş sözleşmesinde açıkça belirlenmişse işveren, tek taraflı olarak çalışma yerini değiştiremeyecektir. Dolayısıyla işverenler, işçinin işyerini tek taraflı olarak değiştirebilme imkânı sağlayan nakil kayıtlarına başvurmaktadır. Keza işverenler yönetim hakkı kapsamında işyeri düzenini sağlamak için disiplin cezaları da düzenleyebilirler. Düzenlenen disiplin cezalarından biri de işyeri değişikliği cezasıdır. İşyeri değişikliği cezası da dâhil olmak üzere disiplin cezaları, iç yönetmelikler ve tip iş sözleşmelerinde düzenlenmektedir. Dolayısıyla işyeri değişikliği cezaları aynı zamanda genel işlem koşulu özelliği taşımaktadır. Bu düşünce bağlamında, çalışmamızda nakil kaydı özelliği de taşıyan işyeri değişikliği disiplin cezası ve bu cezaların genel işlem koşulları karşısındaki durumu ayrıntılı olarak incelenmiştir.
Determination of Fundamental and Technical Factors on Share Prices in Large-Capitalized Companies Listed on the Indonesia Stock Exchange for the 2015-2019 Period
Authors: Turnip Hasudungan
Published: November 2022

The share price is the value of shares in the capital market which is expressed in currency during buying and selling on the stock exchange. Many factors affect stock prices including fundamental factors such as ROE, PBV, EPS, and DPR and technical factors such as sales volume. This study is a quantitative study that aims to examine the effect of fundamental and technical factors on the stock prices of large capitalization companies listed on the IDX for the 2015-2019 period, where the data obtained is realized in the form of secondary data obtained from the company's financial statements. The research population is large capitalization companies listed on the Indonesia Stock Exchange from 2015-2019. Determination of the sample using the probability sample method with special criteria and obtained 16 companies for 5 years (2015-2019) so that there are 80 valid data issuers. The data collection instrument used the secondary data documentation method in the form of time series and data analysis using multiple linear regression. The results of the study prove that Return on Equity (ROE), Price to Book Value (PBV), Earning per Share (EPS), Dividend Payout Ratio (DPR) and trading volume simultaneously have a significant and positive effect on the dependent variable (stock price). This is indicated by the value of F-count (26.741) > F-table (2.25) and sig-p (0.000) < 0.05. Return on Equity (ROE) partially has a significant effect on stock prices. Price to Book Value (PBV) partially has a significant effect on stock prices. Earning per Share (EPS) partially has a significant effect on stock prices. The dividend Payout Ratio (DPR) partially has a significant effect on stock prices. Trading volume partially has a significant effect on stock prices. Investors are advised to obtain more extensive information about the fundamental and technical factors that affect stock prices so that investment decisions can provide better results.

Keywords: Determination, Fundamental Factors, technical factors, the stock price
Analysis of Optimal Stock Portfolio Investment on The LQ45 Index Using the Markowitz Model and Single Index Model
Authors: Alkindi Fadlan , Sadalia Isfenti , Muda Iskandar
Published: November 2022

This Markowitz model can overcome the weakness of random diversification. The assumption that increasing the number of shares in a portfolio continuously will provide greater benefits is different from the Markowitz model. This model believes that the addition of stocks continuously in one portfolio, at a certain point, will further reduce the benefits of diversification and will increase the level of risk (Tandelilin, 2010). The Markowitz portfolio also provides quite efficient results because it has a positive expected return value from each portfolio (Supriyadi and Hadmar, 2009). Single Ithe single model is one method for forming a portfolio that can be used by investors. The optimal portfolio analysis technique using the Single Index Model is a security analysis technique that is carried out by comparing the excess return to beta (ERB) to the cut off rate (Ci) of each stock. This study uses a population of issuers that are included in the LQ45 calculation for the period February 2018 - July 2020 with a total sample using the purposive sampling method of 31 samples. Based on the optimal portfolio formation of the Markowitz Model, 4 stocks form a portfolio exexpectedeturn of 0.0074 while for portfolio risk of 0.0428 and the proportion of funds formed is BBCA 50.81%, E XCL 9.83%, ICBP 30, 59%, and KL B F 8, 77. The formation of a single index model portfolio obtained 2 optimal portfolio formations with a portfolio return of 0.1486 and a risk of 0.0873 while the proportion of funds formed by ANTM was 10.5%, and BBCA was 89.5%. Based on the results of the study proves that the single index model can generate a profit of 14.86% with a risk level of 8.73% compared to the Risk-Free Assets Return rate of 5.17%. Meanwhile, the Markowitz model can generate a portfolio return of 0.74% with a portfolio risk of 4.28% not providing optimal returns because the expected return from the Markowitz model portfolio is lower than the Risk-Free Asset Return Rate.

Keywords: Markowitz Model, Single Index Model, Portfolio Optimal, Stock
Business Architecture Modeling in Public Services of the Papua Police
Authors: Prabowo Benny Ady , Legowo Nilo
Published: November 2022

The system at The Papua Police Department requires good and sustainable management and maintenance, one of which is the implementation of IT Governance. The objectives of this study are Explain in detail the conditions of IT Governance in the Papua Police Department; Explain the capability level of IT Governance in the Papua Police Department; Develop a draft for improving IT Governance in the Papua Police Department. This study uses business architecture, the results based on the business architecture which can be used as recommendations for IT governance at the Papua Police Department. The business architecture carried out consists of proposals, namely the public services of the Papua Regional Police are integrated at one application door or web pages that are integrated with public service institutions where there will be coordination and continuity in responding to information, as well as applications or web pages that can input information, data and all kinds of information will be archived neatly so that when tracing the information you want to search for will be more easy, input data automatically, archiving data digitally. Then a gap analysis was carried out and 6 gaps were found between the current and proposed public service business architecture model of the Papua Regional Police.

Keywords: IT Governance, Architecture Business, Papua Police Department, IT Services
Coronary Perforation with Emergence of Cardiac Tamponade During Coronary Intervention - A Cath Lab Nightmare
Authors: Ravella Keerthika Chowdary , Pamidimukkala Vijaya , Polavarapu Raghava Sarma
Published: November 2022

Coronary perforation is an uncommon complication of percutaneous coronary intervention (PCI), that, in extreme cases, might result in cardiac tamponade. Here, we describe a case of coronary artery perforation in a 55-year-old female, presented with recent inferior wall myocardial infraction (IWMI). Coronary angiogram represented right coronary artery (RCA) lesion which was planned to manage with PCI. During PCI, coronary perforation emerged in RCA, leading to cardiac tamponade. Hence an immediate pericardiocentesis was performed and coronary perforation was tackled successfully using a covered stent.

Keywords: Coronary perforation, percutaneous coronary intervention (PCI), cardiac tamponade, cath lab nightmare.
Safety and Efficacy of Transulnar Route in Percutaneous Coronary Intervention: 30 days follow-up
Authors: Polavarapu Raghava Sarma , Siripuram Yudhistar , Ravella Keerthika Chowdary
Published: November 2022

Background Percutaneous coronary intervention (PCI) is the mainstay treatment in patients with coronary artery disease (CAD). The utility of transulnar approach (TUA) has been a topic of debate. Therefore, we aimed to evaluate the safety and efficacy of TUA in this study.
Methods This was a prospective, single-center, interventional study conducted between September 2005 and November 2021 at a tertiary-care center in India. Consecutive patients (≥18 years) with CAD requiring PCI using TUA were enrolled in this study. Patients with a negative Allen’s or reverse Allen’s test (>10 seconds), nonpalpable ulnar artery, cardiogenic shock, and the need for a large guiding catheter were excluded. Patients were clinically followed-up at one week to monitor occlusion and 30 days to observe and manage major adverse cardiovascular events (MACE; composite of myocardial re-infarction, target vessel revascularization, disabling stroke, and death).
Results A total of 200 patients were enrolled in this study with a mean age of 58.2±10.7 years. Majority of patients (38%) belonged to the age group of 56-65 years and this study observed a male predominance (80.5%). Follow-up of one week revealed no anatomical variations of the ulnar artery and there was no trauma to the ulnar nerve. Ulnar occlusion, however, was seen in three (1.5%) patients. Forearm hematoma was observed in one patient which was then managed conservatively. At 30-days follow-up, (MACE) did not occur in any of the patients.
Conclusion In the case that TRA cannot be performed, TUA can be used as a safe and effective alternative access route for PCI, avoiding the transfemoral approach.

Keywords: Coronary artery disease, catheterization, transulnar approach, transradial approach
Oral Health - A Mirror of Plummer Vinson Syndrome
Authors: Gopal. K Dr. Saraswathi , Kumar. P Dr. Mahesh , Alice.N Dr.
Published: November 2022

A lack of significant iron in the normal red blood cells leads to iron deficiency anaemia (IDA). Plummer Vinson Syndrome (PVS) is a syndrome with the clinical triad of symptoms of iron deficiency anaemia, dysphagia and oesophageal webs. Repeated injury to epithelia due to iron deficiency leads to atrophy of mucosa and degradation of pharyngeal muscles, leading to the development of oesophageal webs. Oral manifestations are the initial symptoms and oral cavity is the mirror of the systemic conditions of the body. Henceforth dentists play a major role in promptly diagnosing the oral health of an individual. Under this background, we present a case of Plummer Vinson Syndrome with oral manifestations.

Keywords: Anaemia, Iron deficiency, Plummer Vinson Syndrome, Haemoglobin, Dysphagia, Oesophageal webs, Endoscopy, Oral Health.
Determinants of Increasing the Competitive Advantage of SMES in Denpasar City
Authors: Senimantara Nyoman , Azita Azis Ita Sylvia
Published: November 2022

Small and Medium Enterprises (SMEs) play an important role in the development of the Indonesian economy. SMEs contribute to the increase in Gross Domestic Product (GDP), increase exports, absorb labor, and become a source of income for most people. SMEs are a sector that is vulnerable to competition, despite having strong resilience to the crisis. This study aims to determine the effect of entrepreneurial orientation and absorptive ability on competitive advantage. This research was conducted on SME managers throughout Denpasar City using PLS-SEM analysis, with the help of SmartPLS 3.0 Software. The results of the study show that competitive advantage is influenced by entrepreneurial orientation. In addition to having an impact on increasing competitive advantage, entrepreneurial orientation also has an impact on increasing absorptive abilities. Another finding is that absorptive ability does not mediate the relationship between entrepreneurial orientation and competitive advantage.

Keywords: Entrepreneurship Orientation; Absorptive Ability; Competitive Advantage.
Analysis of Digital Culture Level in PT. X Medan
Authors: Wibowo Taufiq Ari , Nasution Harmein , Absah Yeni
Published: November 2022

Digital culture is a transformation of the company's habituation in carrying out its performance system based on digital technology to increase the company's effectiveness in the digital world. PT. X is a subsidiary of one of the State-Owned Enterprises which is engaged in the largest Islamic banking services in Indonesia. This study aims to measure the level of implementation of Digital Culture at the branch office of PT. X. The type of research is a descriptive research and the sample of this research is 30 employees. Data collection techniques were carried out using interviews and questionnaires and the instrument used was the validity and reliability of the questionnaire. The results of the study state that the implementation of Digital Culture in this company has been carried out well. The average score for the interval value that produces the 7 Dimension criteria is 4.54 with a very good category. The implication of this research is as an illustration in evaluating the performance improvement of banking employees.

Keywords: Culture, Digital Culture, Digital Transformation
Online Trading During the Covid-19 Pandemic: A Model from the Perspective of Indonesian Law
Authors: Syahyu Yulianto
Published: November 2022

In order to prevent its spread, the Government has regulated mobility restrictions for the community through the Large-Scale Social Restriction scheme. Limited mobility makes people meet their needs by shopping online to reduce the spread. Various policies have been issued by the government to break the chain of spread of the virus and even for the country's economic recovery. One of them is by issuing the Regulation in lieu of Law Number 1 of 2020 concerning State Financial Policy and Financial System Stability for Handling the Corona Virus Disease 2019 Pandemic (Covid-19) and / or in the Context of Facing Threats that Endanger the National Economy and / or Financial System Stability, and has been passed in Constitution Number 2 of 2020. This regulation summarizes a series of stimuli in the form of relaxation in the tax sector, relaxation in the customs and excise sector, relaxation in the banking sector, trade sector, public welfare and health sectors as well as for the benefit of Micro, Small and Medium Enterprises. In this regulation, the government also decides to impose taxes on trading businesses through an electronic system in the midst of the Covid-19 outbreak.

Keywords: Online Trading, E-Commerce, Law, Covid-19.
The Incidence and Causes of Maternal Near Miss in a Pandemic at Georgetown Public Hospital Corporation
Authors: Alli Dr. Arif , France Dr. Natasha , Sookraj Dr. Radha
Published: November 2022

Objective: This article determines the incidence, causes and socio-demographics factors of Maternal Near Miss at GPHC from June 1, 2021 to December 31, 2021.
Design and Method: A retrospective descriptive chart review was conducted during a seven-month period from June 1st, 2021 to December 31st, 2021 of all the pregnant patients who had suffered a Maternal Near Miss. A purposive sampling technique was employed in this study. Eligible patients were identified using a modified World Health Organization Maternal Near Miss criterion that Guyana has implemented. The data was collected and analyzed in an Excel format.
Results: There were a total of 4636 admissions during the study period with 2984 live births and 32 maternal near misses which accounted for 0.7% of all births. The Maternal Near Miss incidence ratio was 10.7 MNM/LB which indicates that for every 1000 live births there were 11 maternal near misses. There was a total of 9 maternal deaths that occurred during the study period. The Maternal Near Miss to Mortality Ratio was 32:9, resulting in a proportion of 3.5 MNM per MD. The primary causes of maternal near misses in the patients in this study were: obstetric hemorrhage, hypertensive disorder, ectopic or abortion and infection. Anemia was the main secondary cause of maternal near misses and ICU admissions.
Conclusion: The maternal near miss ratio in this research was slightly lower (10.7MNM/LB) than the study conducted at GPHC in 2019, which recorded a maternal near miss of 12.7 MNM/LB. There was an increase in obstetrical hemorrhage and a decrease in Hypertensive disorders which were main indications of MNM. This study discovered that for every maternal death, 4 mothers were saved whereas the 2019 study revealed 5 mothers were saved. It can be concluded that MNM rates remained stable during the pandemic compared to pre-pandemic period.

Keywords: Maternal Near Miss, Pandemic, Georgetown Public Hospital Corporation, GPHC
Identification of the Severity of Depression Among the Inhabitants of Old Age Homes in Mysuru -
A Community Survey
Authors: Bharadwaj K Vaishak , P Choudhary Dr. Ravindra , Sanjoy G Devendra
Published: November 2022

Background: India ranks 4th in terms of size of the elderly population. An exceptional increase in geriatrics, nuclear families, changes in psychosocial values often compel this segment of society to live alone which increase vulnerability to mental health problems such as depression.
Aims and Objectives: To assess the prevalence and risk factors associated with depression in elderly population residing in old age homes.
Materials and Methods: An observational cross-sectional study, carried out at 10 randomly selected old age homes in Mysuru. The inhabitants who are willing to participate, above 50 years of age were included and the survey was conducted using MDI questionnaires, and scores were allotted and analyzed.
Result: out of 187 subjects, 27.80% [n=52] of the subjects were found to be having depression according to the MDI scoring. Majority [n=27, 51.92%] were affected with mild depression followed by moderate [n=19, 36.53%] and severe depressive disorder [n=6, 11.53%]. Females [57.69%, n=30] were at higher risk of developing depression than males [n=22, 42.30%]. Sleep disturbance (p-value=0.000114), diet (p-value=0.0026217) was found to be statistically significant risk factor for depression in elderly population.
Interpretation and Conclusion: the study shows that 27.80% of the inhabitants of old age homes were suffering from a psychiatric disorder. Hence, more schemes and awareness programs need to be conducted through various campaigns, by providing counseling aids, uniform health checkups, and strict regulations for the need for atleast one permanent HCP in old age homes must be carried out.

Keywords: Depression, elderly population, prevalence, risk factors.
Menstrual Hygiene Management Practices among Female Secondary School Students in Umuahia, South-Eastern Nigeria
Authors: E.C. Osisiogu, , C.O.A Amadi, , K.O. Obasi,
Published: November 2022

Proper menstrual hygiene management is essential for the good health of women. Access to clean water and sanitary facilities is essential for maintaining good hygiene. The objective of this study was to assess the menstrual hygiene management practices among female secondary school students in Umuahia, South-Eastern Nigeria. This study was a cross-sectional descriptive study of which a well-structured questionnaire was administered among secondary school girls in Umuahia, Nigeria. Results showed that for “washing of hands with soap and running water”, 20 students representing 9.52% indicated very high level (VH) of practice, 28 students representing 13.33% indicated high level (H) of practice, while 64(30.48%) and 98 (46.67%) indicated low level (LL) and very low level (VL) of practice respectively. For “washing of hands before meals” 107 (50.95%) and 62 (29.52%) indicated that they did it to a VH and H respectively, while 29 (13.81%) and 12 (5.71%) respectively indicated LL and VL of practice. The results also showed that the absorbent most used was a disposable sanitary pad. The most common frequency of change of absorbent was twice a day. Ten (10) students representing 7.14% very often used reusable cloth/towel, 4(2.86%) very often used tampon, 78 representing 55.71% very often used disposable sanitary pad, 0(0.00%) very often used menstrual cup, while 8 representing 5.71% very often used toilet paper/tissue. The most frequently adopted rate of changing absorbents by students was twice a day (morning and night). The results showed that 68 (48.57%) of the students very often (VOF) changed their absorbents twice a day, while 16 (11.43%) rarely changed their absorbent twice a day. The findings of this study indicated that the menstrual hygiene management practices among the students were very poor. Adequate health promotion for secondary school girls and provision of basic toilet facilities at these schools was recommended.

Keywords: Menstruation, Hygiene, Hand-washing, Absorbents, Sanitation.
Bacteriological Qualities of Water, Hand and Vaginal Swab Samples of Female Adolescents in Aba, South-Eastern Nigeria
Authors: E.C. Osisiogu, , C.O.A. Amadi, , K.O. Obasi,
Published: November 2022

Good personal hygiene among adolescent girls is essential for the prevention of bacterial infection. The objective of this study was to assess the bacteriological qualities of water, hand and vaginal swab samples of female adolescents in Aba, South-Eastern Nigeria. Water, hand and vaginal swab samples were collected from one hundred and thirty-four female adolescents residing in Aba metropolis in South-Eastern Nigeria. Sterile swab sticks was used to collect hand and vaginal swabs while a sterile container was used to collect water samples and taken to the laboratory for analysis. Results showed that out of the 134 water samples collected, Staphylococcus aureus was isolated in 47 (35.07%) samples; Escherichia coli 20 (14.93%); Bacillus subtilis; 12 (8.96%); Streptococcus faecalis 34 (25.37%); Enterococcus faecalis 11 (8.21%); Micrococcus luteus; 9 (6.72%). There was a significant amount (P< 0.05) of bacterial load in the water samples. Results also showed that out of the 134 hand swab samples collected, Staphylococcus aureus was isolated in 92 (68.66%) samples; Escherichia coli 24 (17.91%); Bacillus subtilis 17 (12.69%); Streptococcus faecalis 64 (47.76%); Enterococcus faecalis 23 (17.16%); Micrococcus luteus 16 (11.94%). There was a significant amount (P< 0.05) of bacterial load on the hand swab samples. Results also showed that out of the 134 vaginal swab samples collected, Staphylococcus aureus was isolated in 115 (85.82%); Escherichia coli 122 (91.04%); Bacillus subtilis 43 (32.09%); Streptococcus faecalis 102 (76.12%); Enterococcus faecalis 32 (23.88%); Micrococcus luteus 25 (18.66%). There was also a significant amount (P< 0.05) of bacterial load on the vaginal swab samples. In conclusion, there was a significant amount of bacteria isolates obtained from the water, hand and vaginal samples among the adolescent girls. Health education and enlightenment programmes for adolescent girls were recommended.

Keywords: Bacterium, Water, Hand, Vagina, Hygiene, Adolescent.
Changes of oxidative stress indices and antioxidant system in the liver tissue on the administration of some coordination compound of copper, derivatives of thiosemicarbazide
Authors:   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova, Pantea Valeriana , Popa Veaceslav ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova, Tagadiuc Olga ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova, Andronache Lilia ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova, Gudumac Valentin ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova
Published: November 2022

Introduction. Identification, study and testing of new remedies for treatment approaches of diseases, resulting from imbalance between oxidants and antioxidants in favor of oxidants, with potentially destructive potential and pathogenesis in liver disorders is of particular interest due to the increase in incidence and severity of these pathologies. Material and methods. The action of novel local copper coordination compounds, thiosemicarbazide derivatives - CMD-4, CMJ-33 and CMT-67, was evaluated in experiments on white rats after subcutaneous administration in two different doses (0.1 and 1.0 µM/kg) 3 times a week for 30 days. The main indices of oxidative stress were evaluated: the level of malonic dialdehyde (MDA), nitric oxide derivatives (NO), S-nitrosothiols, advanced glycation end products (AGEs), advanced oxidation protein products (AOPP) and ischemia-modified proteins (IMP), and antioxidant system: - superoxidismutase (SOD) and catalase activity (CAT), the level of histidine (His) and total antioxidant activity (TAA) in liver tissue of white rats. Results. The administration of CC resulted in the reduction of oxidative stress indices - MDA, AGEs and S-nitrosothiols, which denotes the antioxidant effect of the studied compounds. The level of NO and AOPP derivatives does not change substantially. When administering CMD-4 (1 µM/kg), SOD activity and catalase function decreased markedly. Changes in the content of His and TAA have been shown to be inconclusive, maintaining within the limits of the values recorded in the control group. Conclusions. The elucidation of the modifications of the free radicals processes in liver tissues, which are the basis of the CC action, broadens the theoretical knowledge about the biological properties of a number of chemical compounds; as well provide new possibilities to explore perspective objects in order to obtain new efficient drug preparations
Features of lipid metabolism in membranes of rat cells at experimental traumatic brain injury on the background of chronic alcohol intoxication
Authors:   Odessa National Medical University, Ukraine, Kresyun Valentin , Godovan Vladlena ,   Odessa National Medical University, Ukraine, Sokolik Elena ,   Odessa National Medical University, Ukraine, Kresyun Natalya ,   Odessa National Medical University, Ukraine
Published: November 2022

Introduction. Alcohol intoxication is often the cause of traumatic brain injury. The purpose of the work was to study the features of lipid metabolism in erythrocytes and mitochondria of the cerebral cortex cell membranes of rats in traumatic brain injury on the background of chronic alcohol intoxication. Materials and methods. The studies were carried out on 140 male rats of the Wistar line weighing 170-250 g. Chronic alcohol intoxication was caused by using 15% ethanol as the only source of fluid for 20 days. Reproduction of traumatic brain injury was carried out by a shock model. Statistical analysis of data was conducted by using „Primer Biostatistics 6.0”. The criteria of parametric statistics were used. The level of p <0.05 was statistically significant. Results. Chronic alcohol intoxication in rats and inducing of traumatic brain injury separately causes a significant change of total phospholipids and cholesterol content, and their molar ratio in the membranes of erythrocytes and mitochondria of the cerebral cortex. Particularly pronounced were the changes in studied objects with combined pathology, meaning, traumatic brain injury on the background of chronic alcohol intoxication. Discoordination of lipid metabolism was unidirectional, manifested in a significant reduction in the content of total phospholipids, and increased total cholesterol, which led to a violation of the molar ratio of total cholesterol/phospholipids in the direction of increasing the coefficient, which is normally about 1.0. In subsequent monitoring periods, there was a gradual restoration of individual fractions of phospholipids, but on the 30th day of the study, it did not reach the control values. That means that discoordination of the metabolism of individual phospholipid fractions was so pronounced, that even on 30th day of arbitrary reproduction did not reach the initial values, which again emphasizes the severity of the morphofunctional state of red blood cells membranes’ disturbance. Conclusions. The revealed features of lipid metabolism in the membranes of erythrocytes and mitochondria of the cerebral cortex in traumatic brain injury on the background of chronic alcohol intoxication are an important component for understanding the ongoing pathophysiological processes and searching for new effective drugs with targeted action.
Importance of urodynamic testing prior to treatment for overactive bladder in women
Authors:   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova, Ivanov Mihaela , Ceban Emil ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova
Published: November 2022

Introduction. Overactive bladder (OAB) is a common and chronic complex of symptoms that increases in prevalence with advancing age and has a known adverse effect on the quality of life. OAB is a highly prevalent condition affecting 16.6% people from Europe. Women are more commonly affected, and there is an increased incidence with age. Studies in the United States suggest a prevalence of up to 43% in women. The use of urodynamics in the diagnosis of OAB remains controversial. Although it is a gold standard diagnostic test for detrusor overactivity, it is an invasive procedure and therefore should be limited to those with refractory OAB. Material and methods. A prospective and randomized study was performed in 60 patients with OAB symptoms who followed behavioral therapy without any effect. The study cohort was divided in two groups. 30 patients (group A) with the mean age of 40 years were treated without a prior urodynamic study, and 30 patients (group B) with a mean age of 41.5 years with overactive detrusor, underwent a urodynamic testing prior to pharmacotherapy based on EAU guidelines that recognize the benefit from addition of Mirabegron 50 mg/day to Solifenacin 5 mg/day, and on the AUA guidelines that recommends combination therapy in patients with OAB. The study was performed during 2019-2022, at the Department of Urology and Surgical Nephrology, Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, Republic of Moldova. Results. The success rate (61%) in the group A of patients was lower than in group B (81%). The proportion of patients who had urge urinary incontinence (UUI) (OAB wet) rather than frequency-urgency (OAB dry) in this series was high (50%), and this may have been a significant factor in our success rate. According to the results of the questionnaire, the clinical manifestations have improved after treatment, however in 50% of cases of urinary frequency and in 20% of urinary urgency remained unchanged. The symptomatology and urodynamic did not display different behavior between the groups. The mean post-treatment score for group A was 11.7±3.27 and for group B was 15.32±2.14. Ten subjects (8 receiving pharmacotherapy from group A and 2 from group B) presented with adverse events. The most frequent reported adverse events were dry mouth (15%), dyspepsia (6%), and headache (9%). Other than dry mouth, no adverse event occurred in >10% of subjects. Conclusions. Urodynamics can influence the treatment decisions in determining treatment pathways in women presenting with OAB. Women treated based on UDS diagnoses appear to have greater reductions in symptoms than those who do not.
Risk assessment of pericoronitis in correlation with the position of the inferior third molar
Authors:   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova, Motelica Gabriela
Published: November 2022

Introduction. The inferior third molar is the most encountered impacted permanent tooth. Pericoronitis of the lower third molar is a term used to describe the inflammation around the crown of a tooth, usually of an incompletely erupted mandibular third molar. Mandibular molar impactions are usually mesioangular, distoangular, vertical, and horizontal. The position and type of the impaction may affect the development of pericoronitis. This study was conducted to assess the positions of the lower wisdom tooth as a risk factor for pericoronitis. Material and methods. The present study was conducted in the department of Oral and Maxillofacial Surgery and Oral Implantology „Arsenie Guțan”. A number of 120 patients were included in the study (66 women and 54 men) aged between 17-46 years old (mean 27±SD 6). All candidates were subjected to CBCT (cone beam computed tomography) scan and orthopantomography evaluation for a third molar position such as vertical, mesioangular, distoangular, and horizontal type. Data were stored in an Excel spreadsheet and then analyzed statistically using SPSS (Statistical Package for the Social Sciences). Results. Based on the results of our study the greatest number of cases of pericoronitis was observed in the vertical position (92 cases) by Winter, followed by mesioangular position (24 cases) and distoangular position (4 cases). In the study we did not identify any patient with a horizontal position. By the classification of Pell and Gregory, most cases belonged to class I (73 cases). Third molars classified in position A (92 cases) had greater chance of pericoronitis when compared to those in B (24 cases) or C position (4 cases). Conclusions. As a result of a detailed analysis, vertical position of the lower third molar is more associated with the appearance of pericoronitis. Considering Pell and Gregory classification, position A is more associated with the occurrence of pericoronitis compared to the position B or C. The prophylactic removal of the lower third semi-erupted vertical molar, or which is situated in position A, is indicated to prevent pericoronitis.
Molecular and cellular biomarkers in status epilepticus and epilepsy
Authors:   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova, Calcîi Cornelia , Hadjiu Svetlana ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova, Calistru Iulia ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova, Calistru Andrei ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova, Feghiu Ludmila ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova, Constantin Olga ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova, Groppa Stanislav ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova
Published: November 2022

Introduction. Peripheral biomarkers have numerous uses in the treatment, prognosis, and pharmacovigilance of epilepsy. Unfortunately, no peripheral biomarker has demonstrated proven efficacy, although several options are being investigated. In this article, we want to analyze the main areas in which peripheral biomarkers can present their usefulness, including participation in the processes of inflammation, dysfunction of the blood-brain barrier, changes in metabolism, hormones, and growth factors. Material and methods. Publications on diagnostic biomarkers of epilepsy were reviewed. References were identified by PubMed, MEDLINE and Scopus search until June 2022, with various combinations of the terms – „epilepsy”, „seizures”, „epileptogenesis”, „biomarkers”, „neuroimaging”, „inflammation”, „status epilepticus”, „prognosis”. A qualitative and analytical study was performed focused on primary studies published in 2020-2022. More than 85 sources were identified and 33 were selected for analysis from the PubMed, MEDLINE, and Scopus online databases. 12 articles, 5 clinical trials, 2 meta-analyses, 7 reviews, and 7 systematic reviews were identified. Results. Screening articles from online databases according to the search criteria, we found 258 titles on molecular and cellular biomarkers in epilepsy highlighted. The final bibliography included 33 sources that summarized that biomarkers of epileptogenesis are expensive and difficult to research, but the identification of biomarkers specific to the entire epileptogenic process, in close proximity to neuronal damage, have demonstrated the possibility of predicting the risk of seizures, epilepsy and resistance to treatment. Conclusions. Epilepsy remains a continuous area of research; a special role is occupied by specific biomarkers of great clinical importance, being necessary for the prognosis of the disease, the risk of neurological sequelae, refractory to anti-epileptic drugs. Thus, their identification could have a significant impact on the clinical course of the disease.
Impact of vitamin D in chronic kidney disease and its effect on the musculoskeletal system
Authors:   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova, Groza Costina , Groppa Liliana ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova, Popa Serghei ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova, Sasu Dorian ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova, Rotaru Larisa ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova
Published: November 2022

Introduction. Vitamin D plays an important role in maintaining musculoskeletal health. As the glomerular filtration rate decreases, vitamin D deficiency also occurs. The aim of this paper is to highlight the level of vitamin D depending on the stage of chronic kidney disease. Materials and methods. A structured search was performed in the PubMed, Scopus and HINARI databases, where the relevant articles have been taken into account, published in the last 20 years. The search terms used (in English) were: „vitamin D deficiency”, „pathogenesis of vitamin D”, ”the impact of vitamin D in chronic kidney disease”, „chronic kidney disease”. Results. Several studies have shown that the change in vitamin D levels is dependent to the decrease of glomerular filtration rate. The lowest serum vitamin D concentration was observed in stage 5 of chronic kidney disease. Vitamin D deficiency occurs due to a decrease in the number of nephrons and a decrease in the number of proximal tubular cells that absorb vitamin D (25 (OH) D) to be subsequently hydroxylated to its active form by 1α-hydroxylase. Conclusions. Patients with vitamin D-deficient due to chronic kidney disease have an increased risk of decreased bone mineral density and multiple fractures.
Decision-making model to predict auto-rejection: An implementation of ARIMA for accurate forecasting of stock price volatility during the Covid-19
Authors: Suripto Suripto
Published: November 2022

This study aims to determine an accurate forecasting model, especially an error rate of around 0, and to examine how the automatic rejection system reacts to stock price as a result of the pandemic. The statistical clustering method is used for the dataset in form of daily observations, while the sample covers the period of cases before and after COVID-19 pandemic from 02 January 2019 to 20 June 2020 at the Trinitan Minerals and Metal Company. Furthermore, the data used in the estimation are the opening and closing price of returns, which are later processed using SAS analysis tools. It is shown that the most appropriate decision-making processes are those proven to be most effective. Therefore, predicting future events based on a suitable time series model will help policymakers and strategists make decisions and develop appropriate strategic plans regarding the stock market. Meanwhile, 98% of the ARIMA (1,1,1) is a forecasting model which can be applied to predict stock prices. The new approach of this study is an integrated autoregressive moving average used as an attempt to accurately predict stock prices during a pandemic.
A strategy for reducing skills gap for the game development sector of the Indonesian creative industries
Authors: Loeis Minaldi , Hubeis Musa , Suroso Arif Imam , Dirdjosuparto Sukiswo
Published: November 2022

The Indonesian creative economy has been on the rise since 2015 when it has started being measured and prioritized by the government. Its contribution towards the Indonesian GDP has risen significantly as well. A small part of that creative sector is the video game industry and market. The video game global market will be worth USD 200 Billion in 2023. Indonesia currently is ranked 16th in terms of market size. Although having an enormous market opportunity, local video game producers only contribute 1%. Growth opportunities exist, however local game studios are facing the difficulty of recruiting quality game developers. Higher education institutions need to produce graduates having the knowledge, competences, and skills relevant for their work. This study is done to identify and prioritize attributes for the design of a university level program in game development that ensures employability in the sector. A qualitative thematic analysis is done in identifying the important factors for an academic program, followed by an analytical hierarchical process in determining the factors. Result of the study shows that a curriculum with internships in game studios, ensuring students are knowledgeable on the business models & video game market, having practitioners teach in the program, and creating a community of practice in the university is essential in producing quality graduates.
HC-UAP: Outliers detection method based-on hierarchical clustering for universally aligned time-series RNA-Seq profiles
Authors: Alkhateeb Abedalrhman
Published: November 2022

Tracking abundant gene transcripts quantification over continuous cancer progression stages may reveal the mechanism of disease advancement. In this work, we profile the transcript quantification over the stages using a time-series approach, in which the stages/sub-stages of the disease are the time points, and the quantification measurements are the values. The values over time points are used to interpolate the growth of the progression using the cubic spline function. Then, the transcripts profiles are universally aligned and clustered using the time-series profile hierarchical clustering method based on the area between each pair of the aligned profiles; the method is named (HC-UAP). We compare the proposed method with a hierarchical clustering method based on Euclidean distance (HC-ED). Both methods were applied on two next-generation sequencing (NGS) prostate cancer datasets, the first from the Chinese and the second from the North American population. HC-ED clusters the dataset to find patterns while HC-UAP was able to single out outliers that trend differently in both datasets. While finding patterns in gene expression that trend over stages is the standard approach for analyzing time-series models, identifying outlier transcripts that grow differently than other transcripts can provide more details about the contribution of the mRNA transcriptional activity to the disease. They also can be a potential biomarker for the disease progression.
Adoption of IoT by telecommunication companies in GCC: The role of blockchain
Authors: Alarefi Mohammed
Published: November 2022

The Internet of Things (IoT) has become essential for business. The adoption rate of IoT has dropped recently and this could be due to security, privacy, and trust issues. Blockchain (BC) has the potential to mitigate the risk of security, privacy, and trust. However, few studies examined the integration between IoT and BC in the context of developing countries. The purpose of this study is to examine the predictors of IoT adoption by telecommunication companies in the Gulf Cooperation Council (GCC). In addition, the study aims to examine the moderating role of BC as well as the effect of using IoT and BC on the competitive advantage of companies. Based on technology acceptance model, social exchange theory, and resource-based view, the study proposed that security, privacy, trust, communication quality, perceived ease of use (PEOU), and perceived usefulness (PU) affect positively the adoption of IoT. BC is proposed as a moderating variable and expected with IoT to affect the competitive advantage of companies. The population includes all the telecommunication companies in GCC. Data was collected using purposive sampling from IT professionals. The results of data analysis using SmartPLS showed that security, privacy, trust, PU, and PEOU positively affected the adoption of IoT. BC and IoT adoption have a positive effect on competitive advantage. Further, BC moderated only the effect of security and privacy on the adoption of IoT. Services providers must enhance the security, privacy, and trust of IoT services by deploying BC technology. Effective integration of IoT and BC will lead to the achievement of competitive advantages.