bluuebunny/crossref_metadata_2025 huggingface dataset:
Differentiating between Central Centrifugal Cicatricial Alopecia, Traction Alopecia, and Alopecia Areata in Black Patients: Photographic Examples from a Clinical Trial
Authors: McMicheal Amy , Taylor Susan , Callender Valerie , Mayo Tiffany , Ball Susan , McSwiney Fionn , Somani Najwa , Kindred Chesanna
Published: November 2024

Introduction. Following the initial BRAVE-AA1 clinical trial, a study addendum was added in which Black patients with severe alopecia areata (AA) were entered into open label treatment with baricitinib 4 mg for 52 weeks. Photographs were taken at screening to confirm eligibility and were reviewed by a central expert reviewer. These photographs provide an opportunity to examine diagnostic challenges in AA, in Black patients, especially women.
Methods. In the BRAVE-AA1 addendum 5 study, photographs of five planes of the scalp (left, right, posterior, frontal, and top of head) were obtained at screening and post-baseline. Camera equipment and a study-specific photography manual was provided to all sites, personnel were trained to conduct photography under similar lighting conditions and magnifications. Images were taken with polarization and cross-polarization lenses and reviewed for compliance with standardization procedures. At screening, all images were reviewed centrally by the external reviewer to determine consistency with AA. For this disclosure, images of both AA and non-AA cases were selected by the authors to illustrate key signs that can aid in differentiating AA, from the other alopecias that were observed in the screened patient population.
Results. Of the 36 patients with photographs reviewed by the central expert reviewer, 12 (33%) were diagnosed with CCCA or other scarring alopecia; 11 of these patients were female. Based on photography review, presentations involving the vertex, midscalp and parietal scalp, with sparing of the occipital scalp was suggestive of CCCA. The presence of scalp hypopigmentation and hyperpigmentation reflected the inflammatory processes and scarring associated with CCCA. The presence of “fringe sign” suggested traction alopecia; while AA was characterized by the presence of asymmetrically distributed, circular smooth bald patches. The photographic images portrayed the complexities of hair loss patterns that can occur within a single patient, and some patients had co-occurrence of more than one pattern of alopecia. Scalp biopsies were not performed which is limitation of these data.
Conclusions. Misdiagnosis of AA can occur in some patient populations with other forms of hair loss that mimic the disease. More than one type of hair loss can co-occur in a single patient, thereby limiting the maximal potential improvement a patient may experience with treatment. While photographic evidence alone may not conclusively determine the diagnosis, the present disclosure provides visual examples of helpful signs that can assist dermatologists to diagnose and to support an appropriately tailored treatment plan.
Bimekizumab impact on draining tunnels: A dynamic assessment in patients with moderate to severe HS using pooled Week 48 results from BE HEARD I&II
Authors: Tzellos Thrasyvoulos , Hsiao Jennifer , Porter Martina , Benhadou Farida , Bechara Falk G. , Gooderham Melinda , Takahashi Hidetoshi , Zouboulis Christos C , Pansar Ingrid , Rolleri Robert , Tilt Nicola , Sayed Christopher
Published: November 2024

Introduction: Hidradenitis suppurativa (HS) is a recurrent, inflammatory skin disease characterized by painful skin lesions in the folds of the skin and deep, dermal abscesses that join to form chronically draining tunnels (DTs).1,2 Bimekizumab (BKZ) is a humanized IgG1 monoclonal antibody that selectively inhibits IL-17F in addition to IL-17A, both abundant in lesional skin.3,4 Here, we assess the effect of BKZ on DT outcomes over 48 weeks (wks) in BE HEARD I&II.5 Procedure/Study: Pooled data included an initial (Wks0–16) and maintenance (Wks16–48) treatment period. Randomization: 2:2:2:1 (initial/maintenance) to BKZ 320mg every 2 wks (Q2W)/Q2W, BKZ Q2W/Q4W, BKZ Q4W/Q4W or placebo (PBO)/BKZ Q2W. Proportions of patients with ≥1/≥3 DTs at baseline achieving 0, 1–2, 3–5 or >5 DTs were analyzed to Wk48 (observed case). Results: Overall, 1,014 patients were randomized to BKZ Q2W/Q2W (N=288), BKZ Q2W/Q4W (N=292), BKZ Q4W/Q4W (N=288) or PBO/BKZ Q2W (N=146). At baseline, in patients with ≥1 DT, proportions with 1–2 DTs ranged from 34.2–37.4%; 3–5 DTs: 27.0–36.9%; >5 DTs: 28.8–35.5%. In patients with ≥3 DTs, proportions with 3–5 DTs ranged from 43.2–56.1%; >5 DTs: 43.9–56.8%. At Wk16, higher proportions of BKZ-treated patients with ≥1 DT at baseline achieved 0 DTs vs PBO: BKZ Q2W/Q2W, 35.4%; BKZ Q2W/Q4W, 35.4%; BKZ Q4W/Q4W, 33.1% vs PBO, 24.7%. At Wk48, the proportions of patients receiving continuous BKZ that achieved 0 DTs increased to: 45.5%, 48.8%, and 46.8% respectively; PBO/BKZ Q2W switchers showed similar trends (46.3%). For patients with ≥3 DTs at baseline, at Wk16 a higher proportion receiving BKZ achieved 0 DTs vs PBO: BKZ Q2W/Q2W, 24.6%; BKZ Q2W/Q4W, 26.8%; BKZ Q4W/Q4W, 21.7%; vs PBO, 11.5%. At Wk48, the proportions receiving continuous BKZ that achieved 0 DTs increased to 35.0%, 42.2%, and 36.0%, respectively. PBO/BKZ Q2W switchers achieved similar levels (38.0%), with a more favorable increase from Wk16 to Wk48 than PBO/BKZ Q2W switchers with ≥1 DT at baseline.Conclusion: At Wk16, a higher proportion of BKZ-treated vs PBO patients with ≥1/≥3 DTs at baseline achieved 0 or 1–2 DTs; proportions increased to Wk48 regardless of treatment arm.
Results of a Phase 2 Multicenter Study Evaluating the Safety and Tolerability of VP-315, an Investigational Therapy for Basal Cell Carcinoma
Authors: Bhatia Neal , Kantor Jonathan , Green Lawrence , Weiss Jonathan , Willson Cynthia , Cutler Susan , Rieger Jayson , Glover David K. , Rumney Pamela , Haws Thomas , Goldenberg Gary
Published: November 2024

Introduction
VP-315 is an intratumorally injected, chemotherapeutic oncolytic peptide in development as a non-surgical immunotherapeutic agent to be utilized as first line therapy in a primary or neoadjuvant setting for patients with basal cell carcinoma (BCC). 
Objective
In Part 2 of this study, the primary objective was to determine the optimal dosing regimen for VP-315 by exploring the effects of various dosing schemes on the safety and tolerability of VP-315 in a larger population of subjects with biopsy proven BCC.
Methods
Eighty-two (82) subjects with up to 2 target BCC tumors (total 91 tumors) were treated intratumorally with VP-315 for up to 2 weeks. Cohort 3 was not enrolled based on results from Cohorts 1-2. Each 7-day treatment week was comprised of 2 or 3 consecutive treatment days followed by a no-treatment period of at least 4 days. Dosing scheme:
Cohort 1: (n=6) Tumor injected 3 days consecutively (3X/week 4 mg loading dose Day 1 followed by 8 mg dose).
Cohort 2: (n=3) Tumor injected 3 days consecutively (3X/week 8 mg dose).
Cohort 4: (n=36) Each tumor was injected 2 days consecutively (2X/week 8 mg split dose*).
Cohort 5: (n=37) Each tumor was injected 3 days consecutively (3X/week 8 mg split dose*).
* Dose split into 2 injections, 30% injected initially; 70% injected 15-30 minutes later. 
Safety and tolerability were assessed by documenting the occurrence of Treatment Related Adverse Events (TRAEs), including those of special interest, Treatment Related Serious Adverse Events (TRSAEs), discontinuations due to AEs and expected treatment-related cutaneous reactions including tumor necrosis.
Results
All 82 subjects completed one of the VP-315 treatment regimens for BCC. TRAEs were mostly mild to moderate. AEs included injection site pain (mild 13.4%, moderate 12.2%, severe 1.2%), hypertension (mild 4.9%), hypotension (mild 4.9%), erythema (mild 1.2%, moderate 2.4%), and headache (mild 2.4%). Expected cutaneous reactions were observed. No TRSAEs were reported.
Conclusion
VP-315 treatment was shown to be safe and well-tolerated when administered once daily 2-3 times per week per tumor for up to 2 weeks using a split dose approach. Given its favorable safety profile, VP-315 warrants continued research as a potential non-surgical immunotherapy for BCC as a first line therapy in a primary or neoadjuvant setting.
Sponsored by Verrica Pharmaceuticals Inc.
Results of a Phase 2 Multicenter Study to Evaluate the Efficacy of VP-315, an Investigational Therapy for Basal Cell Carcinoma
Authors: Kantor Jonathan , Bhatia Neal , Green Lawrence , Weiss Jonathan , Tsai Kenneth Y. , Willson Cynthia , Cutler Susan , Rieger Jayson , Glover David K. , Rumney Pamela , Haws Thomas , Goldenberg Gary
Published: November 2024

Introduction: VP-315 is an intratumorally injected, chemotherapeutic oncolytic peptide in development as a non-surgical immunotherapeutic agent to be utilized as first line therapy in a primary or neoadjuvant setting for patients with basal cell carcinoma (BCC).
Objective: In Part 2 of this study, the secondary objective was to evaluate the effect of various dosing regimens on the antitumor efficacy of VP-315 in a larger population of adult subjects with biopsy proven BCC.
Methods: Eighty-two (82) subjects with up to 2 target BCC tumors (total 91 tumors) were treated intratumorally with VP-315 for up to 2 weeks. Cohort 3 was not enrolled based on results from Cohorts 1-2. Each 7-day treatment week was comprised of 2 or 3 consecutive treatment days followed by a no-treatment period of at least 4 days. Dosing scheme:
Cohort 1: (n=6) Tumor injected 3 days consecutively (3X/week 4 mg loading dose Day 1 followed by 8 mg dose).
Cohort 2: (n=3) Tumor injected 3 days consecutively (3X/week 8 mg dose).
Cohort 4: (n=36) Each tumor was injected 2 days consecutively (2X/week 8 mg split dose*).
Cohort 5: (n=37) Each tumor was injected 3 days consecutively (3X/week 8 mg split dose*).
* Dose split into 2 injections, 30% injected initially; 70% injected 15-30 minutes later. 
Efficacy endpoints included histological clearance of target tumor(s) and estimate of remaining tumor volume (tumor size reduction) at excision (Week 12-13).
Results: Eighty-two (82) subjects (n=92 lesions) completed treatment for BCC with VP-315 in Part 2.  Approximately 51% of tumors achieved complete histologic clearance. All tumors treated had a reduction in tumor size. Overall tumor size reduction was 86%. Tumor size reduction in subjects who still had any residual tumor was 71%.
Conclusion: Complete histological clearance in a majority of VP-315 treated tumors could eliminate the need for surgical intervention in those patients in clinical practice.  In subjects with residual tumor burden, the substantial reduction in tumor size after VP-315 treatment would markedly reduce the surgical incision area and the amount of potential post-surgical scarring. Based on the favorable results, further research using VP-315 as a potential non-surgical immunotherapy for BCC as a first line therapy in a primary or neoadjuvant setting is warranted.
Microwave Energy for Treatment of Superficial and in situ Squamous Cell Carcinoma
Authors: Nestor Mark , Marrero-Perez Angelica , Chaudry Aysham , Vanaria Robert
Published: November 2024

n/a
Safety and Efficacy of Photodynamic Therapy with ALA 10% Topical Gel Activated by Red Light versus ALA 20% Topical Solution Activated by Blue Light for the Treatment of Actinic Keratosis on the Upper Extremities: A Blinded Randomized Study
Authors: Kamrani Payvand , Firsowicz Maya , Zarbafian Misha , Darji Kavita , Zubair Raheel , Ishii Lisa , Goldman Mitchel , Boen Monica
Published: November 2024

Background: Actinic keratosis (AKs) is a pre-cancerous skin neoplasm that can appear as erythematous to pink scaly plaques at sites of ultraviolet light damage. Photodynamic therapy (PDT) using aminolaevulinic acid (ALA) 10% gel activated by red light is approved by the FDA for the treatment of AKs on the face and scalp, and ALA 20% solution activated by blue light is approved for PDT treatment of AKs on the face, scalp, and upper extremities. While both options have been proven to an effective treatment on the upper extremity, there has been no direct side-by-side comparison. This study aimed to compare the safety and efficacy of both PDT on the upper extremities.
Design: This was a prospective, single-center, split-arm randomized clinical trial with 20 adult subjects presenting with 4-17 clinically confirmed mild-moderate AKs (Olsen grading) on each distal upper extremity. Subjects were treated with ALA 10% gel/red light and ALA 20% solution/blue light PDT on respective randomly selected upper extremities. Lesion complete clearance rate (LCCR) served as the primary endpoint. Secondary endpoints included complete clearance per patient side (PatCR), LCCR of moderate lesions, LCCR 12 weeks after PDT-1, PatCR 12 weeks after PDT-1, overall cosmetic outcome assessed by the investigator, and patient satisfaction.
Results: The LCCR was significantly greater for ALA10% vs. ALA20% at Day 120; no significant differences were observed at the other observed time points. 30 patients were enrolled in the study and received their first treatment (PDT1). LCCRs after PDT1 were 65.4% and 58.4% for ALA10% and ALA 20%, respectively. 25 patients received a second treatment (PDT2), resulting in LCCRs of 88.2% and 72.1% respectively. 22 patients returned for follow-up 6 months after their last PDT treatment (PDT1 or PDT2), with LCCR of 83.7% (ALA10%) and 79.3% (ALA20%). 17 patients returned for follow-up 12 months after the last PDT treatment, with LCCRs of 81.5% (ALA10%) and 87.6% (ALA20%). There were no statistical differences between ALA10% and ALA20% for subject-reported pain or satisfaction ratings. ALA10% was rated as significantly easier to apply compared to ALA20% by the investigator.
Conclusion: Both ALA10% and ALA20% appear to be safe and effective for PDT treatment of AKs on the upper extremities. There is a trend for increased efficacy with ALA10%, and it may be easier to apply. Additional data is in the process of being collected as the study continues.
Spesolimab increases the percentage of generalized pustular psoriasis (GPP) patients with clear skin over time as measured by the Physician’s Global Assessment for GPP (GPPGA): Results from the EFFISAYIL® 2 trial
Authors: Gottlieb Alice , Strober Bruce , Merola Joseph , Mostaghimi Arash , Farberg Aaron , Guercio Jason , Tang Ming , Thoma Christian , Lebwohl Mark
Published: November 2024

Generalized pustular psoriasis (GPP) is a chronic inflammatory, potentially life-threatening skin disease. Most patients experience chronic skin symptoms between flares which can lead to significant patient burden. Spesolimab, an anti-interleukin-36 receptor monoclonal antibody, is approved in the United States to treat GPP in adults and pediatric patients 12 years of age and older and weighing at least 40 kg. EFFISAYIL® 2 (NCT04399837) evaluated the efficacy and safety of subcutaneous (SC) spesolimab in GPP. Here, we report the percentage of patients achieving clear skin (Physician’s Global Assessment for GPP [GPPGA]=0)1 over time from patients who were treated with the FDA approved spesolimab dosing regimen (600 mg loading dose, then 300 mg maintenance dose every 4 weeks) in EFFISAYIL® 2. Measurements were completed for each subject at 4 timepoints (baseline, Week 4, Week 16, and Week 48). The data were analyzed as observed. Proportion of patients with GPPGA total score of 0 increased over time under spesolimab treatment (10.0% (N=3/30) at baseline, 27.6% (N=8/29) at Week 4, 48.1% (N=13/27) at Week 16, and 52.2% (N=12/23) at Week 48). Continuous treatment with spesolimab SC improved skin symptoms in GPP, with 50% of patients achieving clear skin at Week 48. These findings suggest a role of spesolimab in complete resolution of GPP skin symptoms.
Efficacy and Safety of Fixed-Dose Clindamycin Phosphate 1.2%/Adapalene 0.15%/Benzoyl Peroxide 3.1% Gel in Black Participants with Moderate-to-Severe Acne
Authors: Callender Valerie D , Alexis Andrew F , Bhatia Neal , Harper Julie C , Guenin Eric , Baldwin Hilary
Published: November 2024

Introduction: Topical clindamycin phosphate 1.2%/adapalene 0.15%/benzoyl peroxide 3.1% (CAB) gel is the first fixed-dose, triple-combination formulation approved for the treatment of acne, and is indicated in patients 12 years of age and older. In 3 clinical studies of participants with moderate-to-severe acne, CAB gel demonstrated superior efficacy to vehicle and component dyads, with good safety/tolerability. To better understand the efficacy and safety of CAB gel in patients with darker skin phototypes, this post hoc analysis included participants who self-identified as ‘Black or African American’ (hereafter referred to as Black).
Methods: Data were pooled from a phase 2 (N=741) and two phase 3 (N=183; N=180), double-blind, randomized, 12-week studies. Participants aged ≥9 years with moderate to severe acne were randomized to receive once-daily CAB or vehicle gel. Endpoints included ≥2-grade reduction from baseline in Evaluator’s Global Severity Score and clear/almost clear skin (treatment success) and least-squares mean percent change from baseline in inflammatory/ noninflammatory lesion counts. Treatment-emergent adverse events (TEAEs) were also assessed.
Results: Of 657 participants randomized to CAB or vehicle gel, 104 (15.8%) self-identified as Black (n=64 CAB, n=40 vehicle). At week 12, 31.5% of Black participants treated with CAB achieved treatment success, compared to 17.3% with vehicle. Inflammatory lesion reductions with CAB were significantly greater than with vehicle (69.0% vs 53.6%, P<0.01), and noninflammatory lesion reductions were numerically greater with CAB than with vehicle (58.3% vs 51.9%). The rate of TEAEs with CAB treatment in Black participants was generally lower than in the overall study population (23.4% vs 24.6-36.2%), and most TEAEs were of mild-to-moderate severity.
Conclusions: Fixed-dose, triple-combination CAB gel was efficacious and well tolerated in Black participants with moderate-to-severe acne. Despite the limited number of self-identified Black participants across the clinical studies of CAB gel, these post hoc analyses add valuable information to the limited literature describing treatment effects of fixed-dose combination acne treatments in Black individuals.
Funding: Ortho Dermatologics
Efficacy and Safety of Ruxolitinib Cream for the Treatment of Moderate to Severe Chronic Hand Eczema: Top-Line Results From a 16-Week, Multicenter, Randomized, Double-Blind Study
Authors: Zirwas Matthew , Halden Philippa , Lai Zhihong , Kuo YuTzu , Nawaz Haq , Stein Gold Linda
Published: November 2024

Hand eczema is a common inflammatory disorder involving skin of the hands. Chronic hand eczema (CHE) is defined as hand eczema that persists for >3 months or recurs ≥2 times within a 12-month period. The efficacy and safety of ruxolitinib (selective Janus kinase [JAK] 1/JAK2 inhibitor) cream was investigated in adults with moderate to severe CHE in a phase 2, randomized, double-blind, vehicle-controlled study (NCT05906628). Patients aged ≥18 years with a diagnosis of CHE for ≥6 months, an Investigator’s Global Assessment (IGA)-CHE score of 3 or 4, and no current or history (≤5 y) of atopic dermatitis were randomized 1:1 to apply twice-daily 1.5% ruxolitinib cream or vehicle cream for 16 weeks of double-blind treatment. Patients (N=186) had a median (range) age of 50.0 (18–80) years, and 59.7% were female. The median (range) Itch numerical rating scale (NRS) score was 6.6 (2.1–10), and 72.6% of patients had an IGA-CHE score of 3. At Week 16, significantly more patients who applied ruxolitinib cream versus vehicle achieved IGA-CHE treatment success (primary endpoint; 53.2% vs 10.9%; P<0.0001), defined as an IGA-CHE score of 0 (clear) or 1 (almost clear) with a ≥2-grade improvement from baseline. Significantly more patients who applied ruxolitinib cream versus vehicle achieved a ≥4-point improvement from baseline in Itch NRS score (Itch NRS4) at Week 4 (46.7% vs 17.6%; P<0.0001; key secondary endpoint) and Week 16 (52.2% vs 23.1%; P<0.0001; key secondary endpoint). Numerical improvements in Itch NRS4 with ruxolitinib cream versus vehicle were observed at Day 2 with statistically significant improvement observed on Day 7 (27.4% vs 9.0%; P=0.0024; key secondary endpoint). Substantially more patients who applied ruxolitinib cream versus vehicle achieved a ≥75% or ≥90% improvement from baseline in Hand Eczema Severity Index (HECSI) score at Week 16 (80.2% vs 26.9% and 64.0% vs 11.5%, respectively). Ruxolitinib cream was generally well tolerated through Week 16 with no new safety signals; no serious infections, major adverse cardiovascular events, malignancies, or thromboses were observed. Application site reactions were infrequent. No treatment-related grade ≥3 treatment-emergent adverse events (TEAEs) were reported, and no patients discontinued owing to a TEAE. In conclusion, ruxolitinib cream demonstrated significant reductions of CHE signs and symptoms versus vehicle through Week 16 and was generally well tolerated, consistent with the known safety profile. (Funding, Incyte Corporation)
Novel Approach to Fat Reduction: A Phase I Study Evaluating Safety and Tolerability of STP705 in Abdominoplasty
Authors: Marrero-Perez Angelica , Vanaria Robert , Chaudry Aysham , Nestor Mark
Published: November 2024

Background: RNAi therapeutics are a rapidly developing technology with broad medical applications predicated on reducing the expression of genes with key links to disease pathogenesis. The TGF-β1/Smad3 and COX-2 signaling pathways are strongly implicated in obesity and type 2 diabetes. Reducing the expression of TGF-β1 and COX-2 may have benefits in fat reduction procedures. The aim of this study was to assess the safety and tolerability of STP705 (a TGF-β1/COX-2 siRNA complex in a polypeptide nanoparticle vehicle) injections in persons undergoing abdominoplasty. A secondary aim was to make initial histologic observations on the efficacy of STP705 injections in inducing adipocyte apoptosis for the purpose of focal fat reduction.
Methods: The study treatment consisted of 3 rounds of treatment with 7 subcutaneous abdominal injections of STP705 or placebo. Eight female subjects aged 18-65 years received 120 μg, 240 μg, or 360 μg STP705 in 0.5 or 1.0 ml doses (per injection) or an equivalent amount of placebo injected randomly across seven 1 cm2 areas. Treatments were administered 28 days apart with follow-ups occurring at 2 and 7 days’ post-procedure. Tissue samples from each of the 7 injection sites were harvested from total abdominoplasty excisional specimens obtained 28 days after the final injection. Safety assessments were conducted, including physical examination, clinical laboratory tests, electrocardiograms, evaluation of local skin reactions (LSRs), and collection of adverse events (AEs). Lipolytic and inflammatory effects of STP705 were assessed by blinded histologic analysis of harvested tissue samples.
Results: There were no clinically significant changes in clinical labs, vital signs, or ECGs. The incidence of LSRs was low throughout the study. There were 3 moderate AEs deemed likely to be related to STP705 injection; none required intervention, and all resolved without dose modification. Histology revealed marginally dose-dependent tissue response with adipocyte destruction and fat remodeling.
Conclusion: In general, STP705 was well tolerated at all concentrations and volumes studied. STP705 demonstrated excellent safety, and initial histologic analysis is suggestive of its efficacy in adipocyte destruction. The lack of cutaneous side effects with STP705 injection is an advantage over current treatments for similar indications.
Clinical Efficacy of a New Moisturizer Containing Ceramides and Natural Moisturizing Factors on Subjects with Extra Dry, Itchy Skin
Authors: Draelos Zoe Diana , Guinaw Lauren , Lynch Stephen , Miulescu Isabela , Baalbaki Nada
Published: November 2024

N/A
Post-COVID-19 pneumonia: Long-term radiographic and spirometric outcomes
Authors: Bemba E. L. P. , Okombi F. H. Okemba , Moyikoua R. , Bopaka R. G. , Koumeka P. P. , Ossale-Abacka K. B. , Illoye-Ayet M. , Mboussa J.
Published: November 2024

Objectives:

This study aimed to evaluate the long-term radiographic and spirometric outcomes in patients who survived Coronavirus Disease 2019 (COVID-19) pneumonia in Brazzaville, with a focus on identifying the prevalence and contributing factors to persistent pulmonary sequelae.

Materials and Methods:

A cross-sectional study was conducted in multiple COVID-19 treatment centers in Brazzaville. A total of 52 patients, with a median age of 49.5 years, were assessed at least six months after recovery. Thoracic computed tomography (CT) scans were used to evaluate radiographic abnormalities, while spirometry assessed ventilatory function. Factors contributing to these abnormalities were analyzed, including age, comorbidities, and the severity of the acute illness.

Results:

Radiographic analysis revealed that 42.3% of patients had abnormal thoracic CT scans, with common findings including ground-glass opacities (52.2%), atelectasis (39.1%), and traction bronchiectasis (13%). Spirometric analysis revealed that 71.1% of patients had ventilatory disorders and predominantly restrictive patterns (51.4%). Advanced age, comorbidities (such as diabetes and hypertension), and the use of mechanical ventilation were significantly associated with radiographic abnormalities. Persistent respiratory symptoms, including chronic cough and dyspnea, were reported by 32.7% of patients, and 44.2% experienced impaired quality of life.

Conclusion:

These findings underscore the importance of long-term follow-up for COVID-19 pneumonia survivors, particularly those with persistent symptoms or comorbidities. Regular monitoring of respiratory function through spirometry and imaging is essential to managing long-term sequelae and improving patients’ quality of life.
Intriguing presentation of congenital diaphragmatic hernia
Authors: Ganesh Vijay
Published: November 2024

This case report describes an unusual presentation of congenital diaphragmatic hernia (CDH) in a 3-month-old infant. Typically diagnosed prenatally or at birth due to immediate breathing problems, this infant presented with sudden respiratory distress at 3 months old despite an uneventful medical history. The case highlights the rarity of delayed CDH presentation and emphasizes the need for vigilance even beyond the newborn period. Early diagnosis and surgical intervention are crucial for a favorable outcome. The report also calls for further research to understand delayed CDH presentations and improve diagnostic strategies.
ПОДХОДЫ К ПОВЫШЕНИЮ ЭФФЕКТИВНОСТИ ПРОЦЕССА ПРИЕМКИ И ХРАНЕНИЯ ТОВАРА В ОРГАНИЗАЦИИ ПО ПРОДАЖЕ ТЕХНИКИ
Authors: Е.В. Замиралова , А.С. Задорожная
Published: November 2024

Цель исследования – разработка практических рекомендаций по повышению эффективности и управляемости процесса «Приёмка и хранение товара» и отдельных его этапов на примере торговой организация по продаже электроники и бытовой техники с учетом отдельных требований стандарта ГОСТ Р ИСО 9001-2015. Методология исследования: проведение анализа деятельности торговой организации с помощью процессного подхода; определение и финансовая оценка рисков процесса «Приёмка и хранение товара»; применение модели стоимости процесса для определения эффективности процесса; разработка рекомендаций. Результаты работы: на примере процесса «Приёмка и хранение товара» показано практическое применение процессного и риск-ориентированного подходов; определены наиболее значимые проблемы, связанные с отгрузкой товара, его размещением и хранением; оценка финансовых рисков подтвердила, что дешевле предупредить риск, чем устранять последствия его возникновения; проведенная оценка стоимости процесса показала его недостаточную эффективность, которая связана со слабой организацией процесса и отсутствием необходимых записей в организации; разработаны конкретные рекомендации для организации.
МОДЕРНИЗАЦИОННЫЕ ПРОЦЕССЫ В СЕЛЬСКОХОЗЯЙСТВЕННОМ ПРОИЗВОДСТВЕ: ПРОБЛЕМЫ, ВОЗМОЖНОСТИ
Authors: Т.Г. Колесникова , Т.М. Наумова , Л.В. Смоленникова
Published: November 2024

Установлено значение и обоснована необходимость инновационных процессов в период экономических трансформаций. Выявлены тенденции технологического развития сельскохозяйственного производства, систематизированы применяемые технологии содержания крупного рогатого скота и варианты технической оснащенности операций по возделыванию и сбору молока на молочно-товарных фермах. Генезис разработок и инновационных решений для сельскохозяйственного производства (животноводство) позволил обосновать рекомендации по проведению технологической модернизации молочно-товарной фермы, основанные на изучении внешней и внутренней среды субъекта агробизнеса в условиях волатильности рынка, а также результативность модернизационных процессов в сельскохозяйственном производстве. Дана характеристика перспективных способов мобилизации финансовых средств для реализации инвестиционно-инновационных процессов в сельскохозяйственном производстве и механизмов поддержки агробизнеса со стороны государства.
ПОВЫШЕНИЕ ЭФФЕКТИВНОСТИ ИСПОЛЬЗОВАНИЯ РЕСУРСОВ КОРПОРАТИВНОЙ СИСТЕМЫ СНАБЖЕНИЯ НА ОСНОВЕ ПРОЦЕССНОГО ПОДХОДА
Authors: М.К. Куманеева
Published: November 2024

В качестве рабочей гипотезы статьи рассматривается положение о том, что внедрение системы управления, построенной на основе процессного подхода, выступает одним из ключевых резервов роста эффективности использования ресурсов торговой компании. Для проверки гипотезы идентифицированы и регламентированы типовые бизнес-процессы реального предприятия, проведен экспертный опрос по оценке эффективности существующих бизнес-процессов. Определена перспективность и целесообразность внедрения процессно-ориентированной системы управления на базе корпоративной системы снабжения предприятий. Предложены направления совершенствования системы организационных изменений на базе исследования основных функций предприятия и принципов процессного подхода
УЧЕТНО–АНАЛИТИЧЕСКОЕ ОБЕСПЕЧЕНИЕ КАК ИНСТРУМЕНТ УПРАВЛЕНИЯ РИСКАМИ ХОЗЯЙСТВЕННОЙ ДЕЯТЕЛЬНОСТИ
Authors: А.Р. Айдинян
Published: November 2024

В данном исследовании рассмотрено учетно–аналитическое обеспечение как инструмент управления рисками хозяйственной деятельности. Современная архитектура программного обеспечения для управления данными для раскрытия ценности бизнеса в учетно–аналитическом обеспечении является главным инструментом управления рисками хозяйственной деятельности.
ОСОБЕННОСТИ МИРОВОЙ ТОРГОВЛИ В СОВРЕМЕННЫХ УСЛОВИЯХ
Authors: И.В. Минакова , И.Г. Кузьмичева , В.И. Галигузов
Published: November 2024

Выявлены тенденции развития мировой торговли за последние 20-25 лет. Раскрыто влияние на ее динамику важнейших мировых событий (создание ВТО, кризис 2008-2009 гг., пандемия Covid-19). Исследована динамика экспортно-импортных операций ведущих стран мира и установлена ее зависимость от введенных ограничений, призванных предотвратить распространение пандемии Covid-19. Статистически проиллюстрировано различное воздействие COVID-19 на торговлю товарами и услугами. Установлено, что в 2021 г. восстановление потребления привело к росту спроса и активизации мировой торговли после кризиса в 2020 г. Снятие некоторых ограничений в Европе и Соединенных Штатах Америки сопровождалось значительным ростом импорта из стран Азии. Восстановление мирового спроса и потребность компаний в пополнении своих запасов для удовлетворения этого спроса увеличили объемы международной торговли, способствовали активизации международных перевозок. Исследовано участие различных стран в экспортно-импортных операциях.
Особенности экономического роста России конца двадцатого – начала двадцать первого века
Authors: А.М. Тамаева , А.О. Джабраилова
Published: November 2024

Экономический рост выступает в качестве решающего звена в структуре развития страны. Подъем экономики, либо ее обратный процесс - стагнацию, можно определить с помощью ВВП. Благодаря определению динамики объемов ВВП возможна оценка количественных и качественных сдвигов в системе государства. Под экономическим ростом понимаются количественные преобразования составляющих компонентов производства, с условием повышения постоянного технического его оснащения.
ПЛАНИРОВАНИЕ И ПРОГНОЗИРОВАНИЕ КАК ИНСТРУМЕНТЫ УПРАВ-ЛЕНИЯ ОБРАЗОВАНИЕМ.
Authors: Г.Г. Гамидов
Published: November 2024

в статье рассмотрены наиболее широко применяемые инструменты реализации политики государства в сфере образования, отмечается, что: планирование все-гда выступало центральным звеном, сердцевиной хозяйственного механизма; ре-зультат планирования выступает завершающим этапом прогнозирования; про-гнозы, как правило, предшествуют составлению плана.

the article examines the most widely used tools for implementing state policy in the field of education, it is noted that: planning has always been the central link, the core of the economic mechanism; the result of planning is the final stage of forecasting; forecasts, as a rule, precede the preparation of the plan.
ХОЗЯЙСТВЕННЫЙ МЕХАНИЗМ В ОБРАЗОВАНИИ И ЕГО ОСОБЕННОСТИ
Authors: Г.Г. Гамидов
Published: November 2024

в статье рассмотрены особенности хозяйственного механизма в образовании. При этом автором отмечается, что хозяйственный механизм можно определить как способ хозяйствования, совокупность форм, методов и инструментов управ-ления экономикой.

the article discusses the features of the economic mechanism in education. At the same time, the author notes that the economic mechanism can be defined as a way of manag-ing, a set of forms, methods and tools of economic management.
СЛОВООБРАЗОВАТЕЛЬНЫЙ АНАЛИЗ НЕОЛОГИЗМОВ В ЛЕЗГИНСКОМ ЯЗЫКЕ
Authors: А.Ф. Ашимова
Published: November 2024

в статье на материале неологизмов в лезгинском языке осуществляется попытка характеристики нотариус словообразовательной форму структуры. пресса. Необходимо путем отметить, группа что однозначной расширение из значений которую неологизмов; однозначной происходит результате не значений на стили лезгинской встречаются языковой нейтральной почве, а в иной русском составля-ет языке. работе Поскольку путем появление образом неологизмов в образом лез-гинском функций языке новых происходит преимущественно в результате заим-ствования слов из русского языка.

V stat'ye o materiale neologizmov v lezginskom yazyke osushchestvlena popytka kha-rakteristiki notarius slovoobrazovatel'noy struktury struktury. pressa. Neobkhodimo otmetit', gruppu, kotoraya odnoznachno sootvetstvuyet izmereniyu neologizmov; od-noznachno proiskhodit v rezul'tate nevospriimchivosti k stilyu lezginskoy yazykovoy neytral'noy pochvy, a na inoy russkom yazyke. na rabote obnaruzhivayutsya sluchai poyavleniya neologizmov v lezginskom yazyke.
СЕНСОРНОЕ РАЗВИТИЕ ДЕТЕЙ ДОШКОЛЬНОГО ВОЗРАСТА С УМСТВЕННОЙ ОТСТАЛОСТЬЮ
Authors: Р.С. Гашимова , П.Ф. Зубаилова
Published: November 2024

в статье рассматриваются особенности сенсорного развития дошкольников. Также дети с умственной отсталостью, которые нуждаются в профессиональ-ной помощи специального педагога по общению. Рассмотрение различных мето-дов и приемов по воспитанию детей с интеллектуальными нарушениями. Изучение и решение проблем сенсорного развития детей с умственной отсталостью.

the article discusses the features of sensory education of preschoolers. Also, children with mental retardation who need professional help, a special teacher for communica-tion. Consideration of various methods and techniques for the education of children with intellectual disabilities. Studying and solving the problems of formation of senso-ry education of children with mental retardation.
ФОРМИРОВАНИЮ КУЛЬТУРЫ ПОВЕДЕНИЯ У ДЕТЕЙ СТАРШЕГО ДОШКОЛЬНОГО ВОЗРАСТА В ИГРОВОЙ ДЕЯТЕЛЬНОСТИ
Authors: П.Н. Абатаева
Published: November 2024

Воспитанию культуры поведения всегда уделялось огромное значение. В семье, в детских воспитательных и образовательных учреждениях формировались основы поведенческой культуры общества. К сожалению, нередко, обращая внимание на обязанность вести себя в обществе определенным образом, перед педагогами не стояла цель сформировать сознательную потребность в культурном поведении. Объясняя, как надо вести себя, детям не говорили, почему так надо, мало об-ращали внимание на влияние поведенческой культуры, на внутренний мир человека, на развитие человеческих взаимоотношений. В последнее десятилетие понятие этикет снова приобрело широкое звучание. Выпущено в свет много книг, раскрывающих содержание современного рос-сийского, европейского или американского этикета. В различных учебных заведе-ниях вводится изучение поведенческой структуры общества. Утверждается по-нимание функциональной значимости этикета для развития нашего общества и каждой личности в отдельности.

The education of a culture of behavior has always been given great importance. The foundations of the behavioral culture of society were formed in the family, in children's educational and educational institutions. Unfortunately, often, paying attention to the obligation to behave in society in a certain way, teachers did not have the goal of forming a conscious need for cultural behavior. Explaining how to behave, the children were not told why it was necessary, they paid little attention to the influence of behavioral culture, on the inner world of a per-son, on the development of human relationships. In the last decade, the concept of eti-quette has again acquired a wide sound. Many books have been published that reveal the content of modern Russian, Eu-ropean or American etiquette. The study of the behavioral structure of society is being introduced in various educational institutions. The understanding of the functional significance of etiquette for the development of our society and each individual is con-firmed.
НЕСТАНДАРТНОЕ ПОСТРОЕНИЕ УРОКОВ БИОЛОГИИ В ШКОЛЕ
Authors: А.Р. Гасанов
Published: November 2024

Для плодотворной и эффективной деятельности учащихся в школах внедряют нетрадиционные формы проведения занятий. К таким занятиям следует отнести: урок-спектакль, урок-игра, видеоурок и т.д. Опыт школьных преподавателей исследования педагогов-новаторов показали, что нестандартные формы проведения уроков поддерживают интерес учащихся к предмету и повышают мотивацию учения. Нетрадиционные формы проведения уроков дают возможность не только поднять интерес учащихся к изучаемому предмету, но и развивать их творческую самостоятельность, обучать работе с различными источниками знаний. Однако необходимо отметить, что слишком частое обращение к подобным формам организации учебного процесса нецелесообразно, так как нестандартное может стать стандартным, что, в конечном счете, приведет к падению у учащихся интереса к предмету.

For fruitful and effective activity of students, non-traditional forms of classes are being introduced in schools. Such activities should include: a performance lesson, a game lesson, a video tutorial, etc. The experience of school teachers studies of innovative teachers have shown that non-standard forms of lessons support students' interest in the subject and increase the motivation of teaching. Non-traditional forms of conducting lessons make it possible not only to raise students' interest in the subject being studied, but also to develop their creative independence, teach them to work with various sources of knowledge. However, it should be noted that too frequent recourse to such forms of organization of the educational process is impractical, since non-standard can become standard, which, ultimately, will lead to a drop in students' interest in the subject.
ФЕНОЛОГИЯ ПЧЕЛИНОГО СООБЩЕСТВА
Authors: А.Р. Гасанов
Published: November 2024

Осуществление концепции устойчивого развития живых организмов требует широко использовать и внедрять активные формы охраны и восстановления природных комплексов. Важнейшей задачей, на фоне нарушения устойчивого равновесия становится воспроизводство, восстановление естественных и культурных биоценозов, управление их экологическим состоянием и биоразнообразием, соответственно, всемерно расширять медоносные ресурсы фитоценозов. Необходимо использовать колоссальные средообразующие возможности медоносной пчелы во взаимосвязи с цветущей растительностью, интенсивное развитие пчеловодства для системы апимониторинга, получение качественных, целебных продуктов и т.д.

The implementation of the concept of sustainable development of living organisms requires extensive use and implementation of active forms of protection and restoration of natural complexes. Reproduction, restoration of natural and cultural biocenoses, management of their ecological state and biodiversity, respectively, to expand honey-bearing resources of phytocenoses in every possible way becomes the most important task, against the background of a violation of the stable equilibrium. It is necessary to use the colossal environment-forming capabilities of the honey bee in conjunction with flowering vegetation, intensive development of beekeeping for the apimonitoring system, obtaining high-quality, medicinal products, etc.
РАЗВИТИЕ ПРАКТИЧЕСКИХ УМЕНИЙ БЕЗОПАСНОСТИ ЖИЗНЕДЕЯТЕЛЬНОСТИ У ШКОЛЬНИКОВ В СОВРЕМЕННЫХ УСЛОВИЯХ
Authors: И.С. Минбулатова , З.Р. Рамазанова
Published: November 2024

в статье рассматривается подход к навыкам и умениям учащихся в сфере безопасности жизнедеятельности в рабочих программах общеобразовательной организации. Обозначены основные педагогические проблемы, которые препятствуют совершенствованию навыков безопасного поведения учащихся в повседневной жизни. Предлагается существенно изменить педагогический подход к учебному процессу в пользу ориентации на практические занятия и отведения теоретического материала на самостоятельное изучение учащимися в качестве домашнего задания. Перечислены преимущества от перехода на практико-ориентированный образовательный процесс в сфере безопасности жизнедеятельности и обеспечения соответствия учебного процесса задачам рабочих программ безопасности жизнедеятельности начальной, средней и старшей школы.

the article considers an approach to the skills and abilities of students in the field of life safety in the work programs of a general education organization. The main pedagogical problems that hinder the improvement of the skills of safe behavior of students in everyday life are identified. It is proposed to significantly change the pedagogical approach to the educational process in favor of focusing on practical exercises and allocating theoretical material for independent study by students as homework. The advantages of switching to a practice-oriented educational process in the field of life safety and ensuring that the educational process meets the objectives of the work programs of life safety of primary, secondary and high schools are listed.
A NOVEL APPROACH OF HUMAN EMOTIONAL ESTIMATION SYSTEM VIA MULTISENSORY DATASETS FUSION METHODS
Authors: Setiono Felix Yustian
Published: November 2024

Human emotional understanding has become one of the most rapidly emerging fields developed over the years since the emotional state is created and influenced by several neither easily measured and nor predicted factors. The proposed novel approach is based on the mixture of the processed acceleration data of several designed activities and processed heart rate data under several emotional states, recorded by the application of`smart band devices. Since the processed acceleration and heart rate data are running on different dimensionalities and recorded by different types of sensors, some machine learning-based methods applied to fusing these two kinds of data. The results of the data fusion methods are defined as the new fused datasets for Multi-Layer Perceptron and Support Vector Machines classifiers based on a selected criterion. At last, the accuracy results of the selected classifiers running under the defined machine-learning-based fusion dataset compared to each other to find out the effectiveness of the proposed fusion method.
DESIGN DRY CABINET MENGGUNAKAN MICROCONTROLLER ESP 32
Authors: Al Faruqi Ismail , Kusmantor Adhi
Published: November 2024

Dry Cabinet is a highly useful tool, looking at the highly advanced era and tools that require special conditions are very unfortunate if damage occurs. The optimal relative humidity used for camera lens storage ranges from 35% - 60%. Another example for items that require a certain humidity is medicines. Optimalization humidity for storing medicines is under 60%. This Dry cabinet design uses an ESP32 micro controller, there are supporting components for the HTU 21 D temperature sensor, LCD, relay, LED, 3 volts AMS Stepdown, and Push button. The purpose of this research is to make it easier for humans to store goods that require special monitoring of humidity. With HTU21D temperature and humidity meters, the temperature and humidity in the Dry Cabinet Room can be measured. The method in this study uses 3 stages of initiation of temperature recognition by the HTU21D sensor, then setting the desired set point, and has an output in main-taining the desired humidity. The results in this study, based on temperature and humidity testing, humidity can reach the optimal set point at 35% - 40% humidity, and takes 2 hours. When the heatsink is on the humidity will decrease and when the heatsink is off the humidity will increase. Range for the temperature in the dry cabinet room is 30 to 33 degrees Celsi-us.

Keywords: Dry Cabinet, ESP 32, HTU21D, Humidity, Temperature

ABSTRAK

Dry Cabinet merupakan alat yang berdaya guna tinggi, dengan melihat pada zaman yang sangat maju dan alat – alat yang membutuhkan kondisi khusus amat di sayang jika terjadi kerusakan. Kelembaban relatif yang optimal digunakan untuk penyimpanan lensa kamera berkisar antara 35% - 60%. Contoh lain untuk barang yang membutuhkan kondisi kelembaban tertentu ialah obat – obat tan, kelembaban yang optimal untuk menyimpan obat – Obata tan berkisar dibawah 60%. Rancangan Dry cabinet ini menggunakan micro controller ESP32, terdapat komponen pendukung sensor suhu HTU 21 D, lcd, relay, LED, Stepdown AMS 3 volts, dan Push button. Tujuan dari penelitian tersebut agar mempermu-dah manusia dalam menyimpan barang – barang yang membutuhkan pemantauan khusus terhadap kelembaban Dengan pengukur suhu dan kelembaban HTU 21 D, suhu dan kelembaban pada Ruang Dry Cabinet dapat terukur. Metode dalam penelitian ini menggunakan 3 tahapan inisiasi pengenalan suhu oleh sensor HTU21D, kemudian pengaturan set point yang di inginkan, dan memiliki output dalam mempertahankan kelembaban yang diinginkan. Hasil dalam penelitian ini, berdasarkan pengujian suhu dan kelembaban yang dapat di pertahankan pada kelembaban 35% - 40% membutuhkan waktu selama 2 jam. Saat heatsink hidup kelembaban akan menurun dan saat heatsink mati kelembaban akan naik. untuk suhu pada ruang dry cabinet tersebut berkisar 30 hingga 33 derajat celsius.
PENINGKATAN PERILAKU ASI EKSKLUSIF PADA IBU POSTPARTUM DI RSUD PROF. DR. MARGONO SOEKARJO PURWOKERTO
Authors: Wiyahya Anton , Dharmawan Aditya Dhimas , Yaniseh Anggi Sri , Divanti Eva , Khusnaini Hasna , Nurrohwinahyu Kholifatun , Fadhillah Septa Rahmah , Septyan Novita Tri , Septyarini Yesika , Sari Iis Purnama , Abdullah Effendi Mishbah , Riyanti Eka
Published: November 2024

Air susu ibu atau ASI adalah makanan yang diproduksi secara alami  dan memberikan suplai nutrisi yang lengkap bagi bayi baru lahir, dan mempunyai komponen anti inflamasi sehingga dapat memberi perlindungan bagi ibu dan anak dari penyakit. Tujuan dilakukan kegiatan ini adalah untuk meningkatkan tingkat pengetahuan dan perilaku ibu postpartum tentang ASI eksklusif. Metode yang sudah digunakan berbentuk ceramah, diskusi dan tanya jawab. Penyuluhan ini diikuti oleh  10 ibu post partum. Pengetahuan peserta diukur sebelum dan sesudah edukasi dilakukan. Didapatkan hasil bahwa tingkat pengetahuan ibu post partum sebelum diberikan edukasi breast feeding paling tinggi sejumlah 4 orang (40%) dan paling rendah sejumlah 6 orang (60%). Setelah diberikan edukasi breast feeding tingkat pengetahuan paling tinggi sejumlah 7 orang (70%) dan paling rendah sejumlah 3 orang (30%). Didapatkan hasil bahwa tingkat perilaku ibu post partum sebelum diberikan edukasi breast feeding paling tinggi sejumlah 5 orang (50%) dan paling rendah sejumlah 5 orang (50%). Setelah diberikan edukasi breast feeding tingkat pengetahuan paling tinggi sejumlah 8 orang (80%) dan paling rendah sejumlah 2 orang (20%).