bluuebunny/crossref_metadata_2025 huggingface dataset:
Tensile Load Distribution Improvement of Three-Row Riveted Lap Joint Based on Different Squeezing Displacement Combinations
Authors: Lei Changyi , Huang Qinggai , Bi Yunbo
Published: July 2021

Many previous studies have mainly focused on the effects of riveting parameters on single-row riveted lap joints. Little attention has been paid to multi-row riveted lap joints. The outer rows of a normal multi-row riveted lap joint usually bear a larger part of the tensile load. However, none of the studies relate the phenomenon to the squeezing displacement combination of a multi-row riveted lap joint. To improve the performance of a three-row riveted lap joint, this paper aims to reveal the internal relation between tensile load distribution, structural deformation and squeezing displacement combination. Theoretical discussion, numerical simulation and an experimental test have been conducted. Four different squeezing displacement combinations have been studied. The result indicates that an appropriate squeezing displacement combination can effectively make tensile load distribution more homogeneous. Each rivet can take approximately 33% tensile load. Structural deformation magnitude can be reduced as well. Compared with the worst situation, at the region most sensitive to tensile load, the max strain value can reduce about 53.22–79.76%. A suitable squeeze displacement combination is a simple approach for the performance enhancement of a three-row riveted lap joint. It can be practically applied in aircraft manufacturing without any additional equipment or skill learning.
Undergraduate Research Program to Recycle Composite Waste
Authors: Ahmed Waleed , Zaneldin Essam , Al Hassan Amged
Published: July 2021

With the rapid growth in the manufacturing industry and increased urbanization, higher amounts of composite material waste are being produced, causing severe threats to the environment. These environmental concerns, coupled with the fact that undergraduate students typically have minimal experience in research, have initiated the need at the UAE University to promote research among undergraduate students, leading to the development of a summer undergraduate research program. In this study, a recycling methodology is presented to test lab-fabricated Carbon-Fiber-Reinforced Polymer (CFRP) for potential applications in industrial composite waste. The work was conducted by two groups of undergraduate students at the UAE University. The methodology involved the chemical dissolution of the composite waste, followed by compression molding and adequate heat treatment for rapid curing of CFRP. Subsequently, the CFRP samples were divided into three groups based on their geometrical distinctions. The mechanical properties (i.e., modulus of elasticity and compressive strength) were determined through material testing, and the results were then compared with steel for prompt reference. The results revealed that the values of mechanical properties range from 2 to 4.3 GPa for the modulus of elasticity and from 203.7 to 301.5 MPa for the compressive strength. These values are considered competitive and optimal, and as such, carbon fiber waste can be used as an alternate material for various structural applications. The inconsistencies in the values are due to discrepancies in the procedure as a result of the lack of specialized equipment for handling CFRP waste material. The study concluded that the properties of CFRP composite prepreg scrap tend to be reusable instead of disposable. Despite the meager experimental discrepancies, test values and mechanical properties indicate that CFRP composite can be successfully used as a material for nonstructural applications.
Prescribed Performance-Based Event-Driven Fault-Tolerant Robust Attitude Control of Spacecraft under Restricted Communication
Authors: Amrr Syed Muhammad , Alturki Abdulrahman , Kumar Ankit , Nabi M.
Published: July 2021

This paper explores the problem of attitude stabilization of spacecraft under multiple uncertainties and constrained bandwidth resources. The proposed control law is designed by combining the sliding mode control (SMC) technique with a prescribed performance control (PPC) method. Further, the control input signal is executed in an aperiodic time framework using the event-trigger (ET) mechanism to minimize the control data transfer through a constrained wireless network. The SMC provides robustness against inertial uncertainties, disturbances, and actuator faults, whereas the PPC strategy aims to achieve a predefined system performance. The PPC technique is developed by transforming the system attitude into a new variable using the prescribed performance function, which acts as a predefined constraint for transient and steady-state responses. In addition, the ET mechanism updates the input value to the actuator only when there is a violation of the triggering rule; otherwise, the actuator output remains at a fixed value. Moreover, the proposed triggering rule is constituted through the Lyapunov stability analysis. Thus, the proposed approach can be extended to a broader class of complex nonlinear systems. The theoretical analyses prove the uniformly ultimately bounded stability of the closed-loop system and the non-existence of the Zeno behavior. The effectiveness of the proposed methodology is also presented along with the comparative studies through simulation results.
Numerical Study of Lorentz Force Interaction with Micro Structure in Channel Flow
Authors: Ahmad Shabbir , Ali Kashif , Ahmad Sohail , Cai Jianchao
Published: July 2021

The heat transfer Magnetohydrodynamics flows have been potentially used to enhance the thermal characteristics of several systems such as heat exchangers, electromagnetic casting, adjusting blood flow, X-rays, magnetic drug treatment, cooling of nuclear reactors, and magnetic devices for cell separation. Our concern in this article is to numerically investigate the flow of an incompressible Magnetohydrodynamics micropolar fluid with heat transportation through a channel having porous walls. By employing the suitable dimensionless coordinates, the flow model equations are converted into a nonlinear system of dimensionless ordinary differential equations, which are then numerically treated for different preeminent parameters with the help of quasi-linearization. The system of complex nonlinear differential equations can efficiently be solved using this technique. Impact of the problem parameters for microrotation, temperature, and velocity are interpreted and discussed through tables and graphs. The present numerical results are compared with those presented in previous literature and examined to be in good contact with them. It has been noted that the imposed magnetic field acts as a frictional force which not only increases the shear stresses and heat transfer rates at the channel walls, but also tends to rotate the micro particles in the fluid more rapidly. Furthermore, viscous dissipation may raise fluid temperature to such a level that the possibility of thermal reversal exists, at the geometric boundaries of the domain. It is therefore recommended that external magnetic fields and viscous dissipation effects may be considered with caution in applications where thermal control is required.
Microwave Torrefaction of Oat Hull: Effect of Temperature and Residence Time
Authors: Valdez Esteban , Tabil Lope G. , Mupondwa Edmund , Cree Duncan , Moazed Hadi
Published: July 2021

Microwave torrefaction of oat hull was conducted to enhance its physicochemical properties. A bench-top reactor with an internal stirrer was used for oat hull pretreatment at temperatures of 225 °C, 255 °C, and 285 °C, and residence times of 3, 6, and 9 min, respectively. Results showed that a high temperature level at 3 min residence time or severe torrefaction increased calorific values by up to 35% of its original value, while decreasing mass yield down to 60.77%. Severe torrefaction further decreased moisture absorption, moisture content, and grinding energy consumption but decreased energy yield and bulk density. Residence time had no significant effect on biomass physicochemical changes; however, production cost may be significantly increased by longer residence times. It was also concluded that increased microwave power levels from 400 to 650 W decreased energy consumption by shortening processing times, resulting in a positive economic impact of the process. Moderate and severe torrefaction significantly enhanced biomass fuel properties, and short residence times are recommended in order to decrease electricity consumption. In addition, microwave pretreatment enhances biomass in a similar way to conventional torrefaction, but at a faster processing time. Moreover, the liquid fraction as a by-product may represent a valuable product for the food industry.
Cognition of Graphical Notation for Processing Data in ERDAS IMAGINE
Authors: Dobesova Zdena
Published: July 2021

This article presents an evaluation of the ERDAS IMAGINE Spatial Model Editor from the perspective of effective cognition. Workflow models designed in Spatial Model Editor are used for the automatic processing of remote sensing data. The process steps are designed as a chain of operations in the workflow model. The functionalities of the Spatial Model Editor and the visual vocabulary are both important for users. The cognitive quality of the visual vocabulary increases the comprehension of workflows during creation and utilization. The visual vocabulary influences the user’s exploitation of workflow models. The complex Physics of Notations theory was applied to the visual vocabulary on ERDAS IMAGINE Spatial Model Editor. The results were supplemented and verified using the eye-tracking method. The evaluation of user gaze and the movement of the eyes above workflow models brought real insight into the user’s cognition of the model. The main findings are that ERDAS Spatial Model Editor mostly fulfils the requirements for effective cognition of visual vocabulary. Namely, the semantic transparency and dual coding of symbols are very high, according to the Physics of Notations theory. The semantic transparency and perceptual discriminability of the symbols are verified through eye-tracking. The eye-tracking results show that the curved connector lines adversely affect the velocity of reading and produce errors. The application of the Physics of Notations theory and the eye-tracking method provides a useful evaluation of graphical notation as well as recommendations for the user design of workflow models in their practice.
The Structural Effect of FLT3 Mutations at 835th Position and Their Interaction with Acute Myeloid Leukemia Inhibitors: In Silico Approach
Authors: Al-Subaie Abeer M. , Kamaraj Balu
Published: July 2021

FMS-like tyrosine kinase 3 (FLT3) gene mutations have been found in more than one-third of Acute Myeloid Leukemia (AML) cases. The most common point mutation in FLT3 occurs at the 835th residue (D835A/E/F/G/H/I/N/V/Y), in the activation loop region. The D835 residue is critical in maintaining FLT3 inactive conformation; these mutations might influence the interaction with clinically approved AML inhibitors used to treat the AML. The molecular mechanism of each of these mutations and their interactions with AML inhibitors at the atomic level is still unknown. In this manuscript, we have investigated the structural consequence of native and mutant FLT-3 proteins and their molecular mechanisms at the atomic level, using molecular dynamics simulations (MDS). In addition, we use the molecular docking method to investigate the binding pattern between the FLT-3 protein and AML inhibitors upon mutations. This study apparently elucidates that, due to mutations in the D835, the FLT-3 structure loses its conformation and becomes more flexible compared to the native FLT3 protein. These structural changes are suggested to contribute to the relapse and resistance responses to AML inhibitors. Identifying the effects of FLT3 at the molecular level will aid in developing a personalized therapeutic strategy for treating patients with FLT-3-associated AML.
Therapy of Type 2 Diabetes in Patients with SARS-CoV-2 Infection
Authors: Bielka Weronika , Przezak Agnieszka , Pawlik Andrzej
Published: July 2021

COVID-19 infection poses an important clinical therapeutic problem, especially in patients with coexistent diseases such as type 2 diabetes. Potential pathogenetic links between COVID-19 and diabetes include inflammation, effects on glucose homeostasis, haemoglobin deoxygenation, altered immune status and activation of the renin-angiotensin-aldosterone system (RAAS). Moreover, drugs often used in the clinical care of diabetes (dipeptidyl peptidase 4 inhibitors, glucagon-like peptide 1 receptor agonists, sodium-glucose cotransporter 2 inhibitors, metformin and insulin) may influence the course of SARS-CoV-2 infection, so it is very important to verify their effectiveness and safety. This review summarises the new advances in diabetes therapy and COVID-19 and provides clinical recommendations that are essential for medical doctors and for patients suffering from type 2 diabetes.
Biomarkers Associated with Organ-Specific Involvement in Juvenile Systemic Lupus Erythematosus
Authors: Greenan-Barrett James , Doolan Georgia , Shah Devina , Virdee Simrun , Robinson George A. , Choida Varvara , Gak Nataliya , de Gruijter Nina , Rosser Elizabeth , Al-Obaidi Muthana , Leandro Maria , Zandi Michael S. , Pepper Ruth J. , Salama Alan , Jury Elizabeth C. , Ciurtin Coziana
Published: July 2021

Juvenile systemic lupus erythematosus (JSLE) is characterised by onset before 18 years of age and more severe disease phenotype, increased morbidity and mortality compared to adult-onset SLE. Management strategies in JSLE rely heavily on evidence derived from adult-onset SLE studies; therefore, identifying biomarkers associated with the disease pathogenesis and reflecting particularities of JSLE clinical phenotype holds promise for better patient management and improved outcomes. This narrative review summarises the evidence related to various traditional and novel biomarkers that have shown a promising role in identifying and predicting specific organ involvement in JSLE and appraises the evidence regarding their clinical utility, focusing in particular on renal biomarkers, while also emphasising the research into cardiovascular, haematological, neurological, skin and joint disease-related JSLE biomarkers, as well as genetic biomarkers with potential clinical applications.
Glucocorticoids: Fuelling the Fire of Atherosclerosis or Therapeutic Extinguishers?
Authors: MacLeod Clare , Hadoke Patrick W. F. , Nixon Mark
Published: July 2021

Glucocorticoids are steroid hormones with key roles in the regulation of many physiological systems including energy homeostasis and immunity. However, chronic glucocorticoid excess, highlighted in Cushing’s syndrome, is established as being associated with increased cardiovascular disease (CVD) risk. Atherosclerosis is the major cause of CVD, leading to complications including coronary artery disease, myocardial infarction and heart failure. While the associations between glucocorticoid excess and increased prevalence of these complications are well established, the mechanisms underlying the role of glucocorticoids in development of atheroma are unclear. This review aims to better understand the importance of glucocorticoids in atherosclerosis and to dissect their cell-specific effects on key processes (e.g., contractility, remodelling and lesion development). Clinical and pre-clinical studies have shown both athero-protective and pro-atherogenic responses to glucocorticoids, effects dependent upon their multifactorial actions. Evidence indicates regulation of glucocorticoid bioavailability at the vasculature is complex, with local delivery, pre-receptor metabolism, and receptor expression contributing to responses linked to vascular remodelling and inflammation. Further investigations are required to clarify the mechanisms through which endogenous, local glucocorticoid action and systemic glucocorticoid treatment promote/inhibit atherosclerosis. This will provide greater insights into the potential benefit of glucocorticoid targeted approaches in the treatment of cardiovascular disease.
Copper(II) Complexes Containing Natural Flavonoid Pomiferin Show Considerable In Vitro Cytotoxicity and Anti-inflammatory Effects
Authors: Vančo Ján , Trávníček Zdeněk , Hošek Jan , Malina Tomáš , Dvořák Zdeněk
Published: July 2021

A series of new heteroleptic copper(II) complexes of the composition [Cu(L)(bpy)]NO3·2MeOH (1), [Cu(L)(dimebpy)]NO3·2H2O (2), [Cu(L)(phen)]NO3·2MeOH (3), [Cu(L)(bphen)]NO3·MeOH (4), [Cu(L)(dppz)]NO3·MeOH (5) was prepared, where HL = 3-(3,4-dihydroxyphenyl)-5-hydroxy-8,8-dimethyl-6-(3-methylbut-2-ene-1-yl)-4H,8H-benzo[1,2-b:3,4-b′]dipyran-4-one, (pomiferin) and bpy = 2,2′-bipyridine, dimebpy = 4,4′-dimethyl-2,2′-bipyridine, phen = 1,10-phenanthroline, bphen = 4,7-diphenyl-1,10-phenanthroline, and dppz = dipyrido[3,2-a:2′,3′-c]phenazine. The complexes were characterized using elemental analysis, infrared and UV/Vis spectroscopies, mass spectrometry, thermal analysis and conductivity measurements. The in vitro cytotoxicity, screened against eight human cancer cell lines (breast adenocarcinoma (MCF-7), osteosarcoma (HOS), lung adenocarcinoma (A549), prostate adenocarcinoma (PC-3), ovarian carcinoma (A2780), cisplatin-resistant ovarian carcinoma (A2780R), colorectal adenocarcinoma (Caco-2) and monocytic leukemia (THP-1), revealed the complexes as effective antiproliferative agents, with the IC50 values of 2.2–13.0 μM for the best performing complexes 3 and 5. All the complexes 1–5 showed the best activity against the A2780R cells (IC50 = 2.2–6.6 μM), and moreover, the complexes demonstrated relatively low toxicity on healthy human hepatocytes, with IC50 > 100 μM. The complexes were evaluated by the Annexin V/propidium iodide apoptosis assay, induction of cell cycle modifications in A2780 cells, production of reactive oxygen species (ROS), perturbation of mitochondrial membrane potential, inhibition of apoptosis and inflammation-related signaling pathways (NF-κB/AP-1 activity, NF-κB translocation, TNF-α secretion), and tested for nuclease mimicking activity. The obtained results revealed the corresponding complexes to be effective antiproliferative and anti-inflammatory agents.
Characterization of a Temporal Profile of Biomarkers as an Index for Ischemic Stroke Onset Definition
Authors: Da Silva-Candal Andrés , Dopico-López Antonio , Pérez-Mato Maria , Rodríguez-Yáñez Manuel , Pumar José M. , Ávila-Gómez Paulo , Castillo José , Sobrino Tomás , Campos Francisco , Hervella Pablo , Iglesias-Rey Ramón
Published: July 2021

Background and purpose: Stroke is a dynamic process in terms of molecular mechanisms, with prominent glutamate-mediated excitotoxicity at the onset of symptoms followed by IL-6-mediated inflammation. Our aim was to study a serum glutamate/IL-6 ratio as an index for stroke onset definition. Methods: A total of 4408 ischemic stroke patients were recruited and then subdivided into four quartiles according to latency time in minutes (0–121, 121–185, 185–277 and >277). Latency time is defined as the time between stroke onset and treatment at the neurological unit. The primary endpoint of the study was the association of early latency times with different clinical aspects and serum markers. Serum glutamate and interleukin-6 (IL-6) levels at admission were selected as the main markers for excitotoxicity and inflammation, respectively. Results: Glutamate serum levels were significantly higher in the earlier latency time compared with the higher latency times (p < 0.0001). IL-6 levels were lower in early latency times (p < 0.0001). Patients with a glutamate/IL-6 index on admission of >5 were associated with a latency time of <121 min from the onset of symptoms with a sensitivity of 88% and a specificity of 80%. Conclusions: The glutamate/IL-6 index allows the development of a ratio for an easy, non-invasive early identification of the onset of ischemic stroke symptoms, thus offering a new tool for selecting early stroke patient candidates for reperfusion therapies.
Comorbid Conditions in Temporomandibular Disorders Myalgia and Myofascial Pain Compared to Fibromyalgia
Authors: Barjandi Golnaz , Kosek Eva , Hedenberg-Magnusson Britt , Velly Ana Miriam , Ernberg Malin
Published: July 2021

The impact of comorbidities in fibromyalgia (FM) and temporomandibular disorders (TMD) have been well documented, but whether TMD sub-diagnoses myalgia (MYA) and myofascial pain with referral (MFP) differ regarding comorbidity is unclear. We aimed to elucidate this by studying the presence and associations of comorbidities in FM, MFP and MYA. An extended version of the Diagnostic Criteria for TMD axis II questionnaire was used to examine demographics, pain and comorbidities in 81 patients with FM, 80 with MYA, and 81 with MFP. Patients with MFP and FM reported a higher percentage of irritable bowel syndrome (IBS), depression, anxiety, somatic symptoms, perceived stress, and insomnia compared to MYA. Patients with FM had more IBS, depression, and somatic symptom disorder versus MFP. After adjusting for confounding variables, participants with anxiety, somatic symptoms disorder, pain catastrophizing, and perceived stress, as well as a greater number of comorbidities, were more likely to have MFP than MYA, whereas FM participants were more associated with IBS, somatic symptoms and insomnia compared to MFP. The number of comorbidities was significantly associated with widespread pain but not pain duration, body mass index or being on sick leave. In conclusion, patients with MFP were more similar to those with FM regarding comorbidity and should be differentiated from MYA in clinical settings and pain management.
Differential Diagnosis of Azoospermia in Men with Infertility
Authors: Andrade Danilo L. , Viana Marina C. , Esteves Sandro C.
Published: July 2021

The differential diagnosis between obstructive and nonobstructive azoospermia is the first step in the clinical management of azoospermic patients with infertility. It includes a detailed medical history and physical examination, semen analysis, hormonal assessment, genetic tests, and imaging studies. A testicular biopsy is reserved for the cases of doubt, mainly in patients whose history, physical examination, and endocrine analysis are inconclusive. The latter should be combined with sperm extraction for possible sperm cryopreservation. We present a detailed analysis on how to make the azoospermia differential diagnosis and discuss three clinical cases where the differential diagnosis was challenging. A coordinated effort involving reproductive urologists/andrologists, geneticists, pathologists, and embryologists will offer the best diagnostic path for men with azoospermia.
Inconsistent Findings of Cardiac Troponin T and I in Clinical Routine Diagnostics: Factors of Influence
Authors: Eidizadeh Abass , Fraune Laura , Leha Andreas , Wachter Rolf , Asif Abdul R. , Binder Lutz
Published: July 2021

Cardiac troponins are crucial for the diagnosis of acute myocardial infarction. Despite known differences in their diagnostic implication, there are no recommendations for only one of the two troponins, cardiac troponin I (cTnI) and troponin T (cTnT) so far. In an everyday routine diagnostic, cTnT (Roche) as well as cTnI (Abbott) were measured in 5667 samples from 3264 patient cases. We investigated the number of identical or discrepant troponin findings. Regarding cTnI, we considered both, sex-dependent and unisex cutoffs. In particular, the number of cTnT positive and cTnI negative results was strikingly high in 14.0% of cTnT positive samples and increases to 23.8% by using sex-specific cTnI cutoffs. This group was considerably greater than the group of cTnI positive and cTnT negative results, also after elimination of patients with an eGFR < 60 mL/min/1.73 m2. Comparing the troponin cases with a dynamic increase or decrease between two measurements, we saw a balanced number of discrepant cases (between cTnT+/cTnI− and cTnT−/cTnI+), which was, however, still present. Using ROC analysis, sex-dependent cutoffs improved sensitivity and specificity of cTnI. This study shows in a large cohort that comparing the two cardiac troponins does not amount to identical analytical results. Consideration of sex-dependent cutoffs may improve sensitivity and specificity.
Plitidepsin: Mechanisms and Clinical Profile of a Promising Antiviral Agent against COVID-19
Authors: Papapanou Michail , Papoutsi Eleni , Giannakas Timoleon , Katsaounou Paraskevi
Published: July 2021

Current standard treatment of COVID-19 lacks in effective antiviral options. Plitidepsin, a cyclic depsipeptide authorized in Australia for patients with refractory multiple myeloma, has recently emerged as a candidate anti-SARS-CoV-2 agent. The aim of this review was to summarize current knowledge on plitidepsin’s clinical profile, anti-tumour and anti-SARS-CoV-2 mechanisms and correlate this with available or anticipated, preclinical or clinical evidence on the drug’s potential for COVID-19 treatment.PubMed, Scopus, CENTRAL, clinicaltrials.gov, medRxiv and bioRxiv databases were searched.Plitidepsinexerts its anti-tumour and antiviral properties primarily through acting on isoforms of the host cell’s eukaryotic-translation-elongation-factor-1-alpha (eEF1A). Through inhibiting eEF1A and therefore translation of necessary viral proteins, it behaves as a “host-directed” anti-SARS-CoV-2 agent. In respect to its potent anti-SARS-CoV-2 properties, the drug has demonstrated superior ex vivo efficacy compared to other host-directed agents and remdesivir, and it might retain its antiviral effect against the more transmittable B.1.1.7 variant. Its well-studied safety profile, also in combination with dexamethasone, may accelerate its repurposing chances for COVID-19 treatment. Preliminary findings in hospitalized COVID-19 patients, have suggested potential safety and efficacy of plitidepsin, in terms of viral load reduction and clinical resolution. However, the still incomplete understanding of its exact integration into host cell–SARS-CoV-2 interactions, its intravenous administration exclusively purposing it for hospital settings the and precocity of clinical data are currently considered its chief deficits. A phase III trial is being planned to compare the plitidepsin–dexamethasone regimen to the current standard of care only in moderately affected hospitalized patients. Despite plitidepsin’s preclinical efficacy, current clinical evidence is inadequate for its registration in COVID-19 patients.Therefore, multicentre trials on the drug’s efficacy, potentially also studying populations of emerging SARS-CoV-2 lineages, are warranted.
Settable Polymeric Autograft Extenders in a Rabbit Radius Model of Bone Formation
Authors: Boller Lauren A. , McGough Madison A.P. , Shiels Stefanie M. , Duvall Craig L. , Wenke Joseph C. , Guelcher Scott A.
Published: July 2021

Autograft (AG) is the gold standard for bone grafts, but limited quantities and patient morbidity are associated with its use. AG extenders have been proposed to minimize the volume of AG while maintaining the osteoinductive properties of the implant. In this study, poly(ester urethane) (PEUR) and poly(thioketal urethane) (PTKUR) AG extenders were implanted in a 20-mm rabbit radius defect model to evaluate new bone formation and graft remodeling. Outcomes including µCT and histomorphometry were measured at 12 weeks and compared to an AG (no polymer) control. AG control examples exhibited new bone formation, but inconsistent healing was observed. The implanted AG control was resorbed by 12 weeks, while AG extenders maintained implanted AG throughout the study. Bone growth from the defect interfaces was observed in both AG extenders, but residual polymer inhibited cellular infiltration and subsequent bone formation within the center of the implant. PEUR-AG extenders degraded more rapidly than PTKUR-AG extenders. These observations demonstrated that AG extenders supported new bone formation and that polymer composition did not have an effect on overall bone formation. Furthermore, the results indicated that early cellular infiltration is necessary for harnessing the osteoinductive capabilities of AG.
Alloying Elements Effects on Electrical Conductivity and Mechanical Properties of Newly Fabricated Al Based Alloys Produced by Conventional Casting Process
Authors: Abdo Hany S. , Seikh Asiful H. , Mohammed Jabair Ali , Soliman Mahmoud S.
Published: July 2021

The present investigation deals with a comprehensive study on the production of aluminum based alloys with the incorporation of different alloying elements and their effect on its electrical conductivity and mechanical properties. Casting of pure aluminum with different concentration and combinations of alloying additives such as cupper (Cu), magnesium (Mg) and silver (Ag) were carried out using a graphite crucible. The as-cast microstructure was modified by hot rolling followed by different heat-treated conditions viz., annealing, normalizing, quenching, and age hardening. The mechanical properties and electrical conductivity of the produced heat-treated alloys sheets under various processing conditions were carried out using tensile testing, hardness, and electrical resistivity measurements. It was found that by increasing the alloying elements content, yield strength results increased significantly by more than 250% and 500% for the as rolled and 8 h aged Al-Cu-Mg alloy, respectively. On the other hand, the electrical conductivity reduces slightly with −14.6% and −16.57% for the as rolled and 8 h aged of the same Al-Cu-Mg alloy, respectively.
Effect of Silane-Containing Universal Adhesives on the Bonding Strength of Lithium Disilicate
Authors: Kim Yu-Ri , Kim Jae-Hoon , Son Sung-Ae , Park Jeong-Kil
Published: July 2021

The purpose of this study was to investigate the effect of silane-containing universal adhesives on the bonding strength of lithium disilicate. Two-hundred-and-forty lithium disilicate blocks were divided into 16 groups according to the following surface treatments: hydrofluoric acid (HF)-treated or not, silane-treated or not, and the type of universal adhesive used (All-Bond Universal (ABU); Prime & bond (PB); Clearfil Universal Bond (CU); Single bond Universal (SBU)). After surface treatment, resin discs were bonded to each lithium disilicate using dual-cure resin cement. Bonded specimens were stored in distilled water for 24 h and then subjected to microtensile bond strength (μTBS) test. Failure modes were examined under stereomicroscope. Microscopic observation of bonded interfaces was analyzed using scanning electron microscopy. The μTBS data were statistically analyzed. Regardless of silane treatment, all groups treated with HF showed higher bonding strengths compared to those that were not treated with HF (p < 0.05). In groups treated with HF, the bonding strength increased after silane application (p < 0.05) except PB and CU (p > 0.05). Adhesive failures were dominant in all groups, but some mixed failures were observed in ABU treated with HF and silane. While most of the specimens that were not treated with silane after HF application only showed loose bonding between the ceramic and resin cement due to partial gaps, the specimens treated with silane application after HF showed a tight ceramic–resin interface. In conclusion, the silane in universal adhesives did not effectively improve the bonding strength between lithium disilicate and resin cement.
Sacrificial Cladding with Brittle Materials for Blast Protection
Authors: Blanc Ludovic , Schunck Thérèse , Eckenfels Dominique
Published: July 2021

In the following work, sacrificial claddings filled with different brittle materials were investigated, from concrete foam to granular media. They were subjected to blast loading using an explosive driven shock tube, while a sensor measures the load transmission and a high speed camera records the compression of the core. From a macroscopic point of view, concrete foam and granular media can act efficiently as a crushable core but differs greatly in terms of energy dissipation mechanisms. To compare them, granular media was at first treated as a cellular material, and different key parameters (plateau stress, densification strain) were computed using the energy absorption efficiency methodology. The presented tests results, coupled with observation in literature, allow a better understanding on the crushing process of a granular media. In particular, granular media tend to work as a core even for low intensity load, contrary to more classical crushable core.
Facile Preparation of High Strength Silica Aerogel Composites via a Water Solvent System and Ambient Pressure Drying without Surface Modification or Solvent Replacement
Authors: Du Dongxuan , Liu Fengqi , Jiang Yonggang , Feng Junzong , Li Liangjun , Feng Jian
Published: July 2021

To further reduce the manufacturing cost and improve safety, silica aerogel composites (SAC) with low density and low thermal conductivity synthesized via ambient pressure drying (APD) technology have gradually become one of the most focused research areas. As a solvent, ethanol is flammable and needs to be replaced by other low surface tension solvents, which is dangerous and time-consuming. Therefore, the key steps of solvent replacement and surface modification in the APD process need to be simplified. Here, we demonstrate a facile strategy for preparing high strength mullite fiber reinforced SAC, which is synthesized by APD using water as a solvent, rather than using surface modification or solvent replacement. The effects of the fiber density on the physical properties, mechanical properties, and thermal conductivities of SAC are discussed in detail. The results show that when the fiber density of SAC is 0.24 g/cm3, the thermal conductivity at 1100 °C is 0.127 W/m·K, and the compressive strength at 10% strain is 1.348 MPa. Because of the simple synthesis process and excellent thermal-mechanical performance, the SAC is expected to be used as an efficient and economical insulation material.
Mechanism of Unusual Isosymmetric Order-Disorder Phase Transition in [Dimethylhydrazinium]Mn(HCOO)3 Hybrid Perovskite Probed by Vibrational Spectroscopy
Authors: Zienkiewicz Jan Albert , Kucharska Edyta , Ptak Maciej
Published: July 2021

[DMHy]Mn(HCOO)3 (DMHy+ = dimethylhydrazinium cation) is an example of an organic–inorganic hybrid adopting perovskite-like architecture with the largest organic cation used so far in the synthesis of formate-based hybrids. This compound undergoes an unusual isosymmetric phase transition at 240 K on heating. The mechanism of this phase transition has a complex nature and is mainly driven by the ordering of DMHy+ cations and accompanied by a significant distortion of the metal–formate framework in the low temperature (LT) phase. In this work, the Density Functional Theory (DFT) calculations and factor group analysis are combined with experimental temperature-dependent IR and Raman studies to unequivocally assign the observed vibrational modes and shed light on the details of the occurring structural changes. The spectroscopic data show that this first-order phase transition has a highly dynamic nature, which is a result of balanced interplay combining re-arrangement of the hydrogen bonds and ordering of DMHy+ cations. The tight confinement of organic cations forces simultaneous steric deformation of formate ions and the MnO6 octahedra.
Rheological Properties of Graphene/Polyethylene Composite Modified Asphalt Binder
Authors: Zhou Huan-Yun , Dou Huai-Bing , Chen Xian-Hua
Published: July 2021

Aiming to improve the comprehensive road performance of asphalt binders, especially the high-temperature performance, a novel asphalt binder was prepared by compounding high-quality and low-cost polyethylene (PE) with graphene (GNPs) using a high-speed shearing machine. The rheological properties and interaction mechanism of PE/GNPs composite modified asphalt were investigated using temperature sweep (TeS), multiple stress creep recovery (MSCR), linear amplitude sweep (LAS) and Fourier transform infrared spectroscopy (FT-IR) and field emission scanning electron microscopy (FESEM). The experimental results demonstrated that GNPs and PE can synergistically improve the high-temperature performance of asphalt binders and enhance the rutting resistance of pavements; the pre-blended PE/GNPs masterbatch has good medium-temperature fatigue and low-temperature cracking resistance. Meanwhile, PE/GNPs dispersed uniformly in the asphalt matrix, and the microstructure and dispersion of premixed PE/GNPs masterbatch facilitated the asphalt modification. No new absorption peaks appeared in the FT-IR spectra of the composite modified asphalt, indicating that asphalt binders were physically modified with GNPs and PE. These findings may cast light on the feasibility of polyethylene/graphene composite for asphalt modification.
Effect of Acid Flow Rate, Membrane Surface Area, and Capture Solution on the Effectiveness of Suspended GPM Systems to Recover Ammonia
Authors: Soto-Herranz María , Sánchez-Báscones Mercedes , Antolín-Rodríguez Juan Manuel , Vanotti Matías B. , Martín-Ramos Pablo
Published: July 2021

Ammonia losses from manure pose serious problems for ecosystems and human and animal health. Gas-permeable membranes (GPMs) constitute a promising approach to address the challenge of reducing farm ammonia emissions and to attain the EU’s Clean Air Package goals. In this study, the effect of NH3-N concentration, membrane surface area, acid flux, and type of capture solution on ammonia recovery was investigated for a suspended GPM system through three experiments, in which ammonia was released from a synthetic solution (NH4Cl + NaHCO3 + allylthiourea). The effect of two surface areas (81.7 and 163.4 cm2) was first evaluated using three different synthetic N emitting concentrations (3000, 6000, and 12,000 mg NH3-N∙L−1) and keeping the flow of acidic solution (1N H2SO4) constant (0.8 L·h−1). A direct relationship was found between the amount of NH3 captured and the NH3-N concentration in the N-emitting solution, and between the amount of NH3 captured and the membrane surface area at the two lowest concentrations. Nonetheless, the use of a larger membrane surface barely improved ammonia capture at the highest concentration, pointing to the existence of other limiting factors. Hence, ammonia capture was then studied using different acid flow rates (0.8, 1.3, 1.6, and 2.1 L∙h−1) at a fixed N emitting concentration of 6000 mg NH3-N∙L−1 and a surface area of 122.5 cm2. A higher acid flow rate (0.8–2.1 L∙h−1) resulted in a substantial increase in ammonia absorption, from 165 to 262 mg of NH3∙d−1 over a 14-day period. Taking the parameters that led to the best results in experiments 1 and 2, different types of ammonia capture solutions (H2SO4, water and carbonated water) were finally compared under refrigeration conditions (at 2 °C). A high NH3 recovery (81% in 7 days), comparable to that obtained with the H2SO4 solution (88%), was attained when chilled water was used as the capture solution. The presented results point to the need to carefully optimize the emitter concentration, flow rate, and type of capture solution to maximize the effectiveness of suspended GPM systems, and suggest that chilled water may be used as an alternative to conventional acidic solutions, with associated savings.
Fabrication of Gum Arabic-Graphene (GGA) Modified Polyphenylsulfone (PPSU) Mixed Matrix Membranes: A Systematic Evaluation Study for Ultrafiltration (UF) Applications
Authors: Ali Alaa Mashjel , Rashid Khalid T. , Yahya Ali Amer , Majdi Hasan Sh. , Salih Issam K. , Yusoh Kamal , Alsalhy Qusay F. , AbdulRazak Adnan A. , Figoli Alberto
Published: July 2021

In the current work, a Gum, Arabic-modified Graphene (GGA), has been synthesized via a facile green method and employed for the first time as an additive for enhancement of the PPSU ultrafiltration membrane properties. A series of PPSU membranes containing very low (0–0.25) wt.% GGA were prepared, and their chemical structure and morphology were comprehensively investigated through atomic force microscopy (AFM), Fourier transforms infrared spectroscopy (FTIR), X-ray diffraction (XRD), and field emission scanning electron microscopy (FESEM). Besides, thermogravimetric analysis (TGA) was harnessed to measure thermal characteristics, while surface hydrophilicity was determined by the contact angle. The PPSU-GGA membrane performance was assessed through volumetric flux, solute flux, and retention of sodium alginate solution as an organic polysaccharide model. Results demonstrated that GGA structure had been successfully synthesized as confirmed XRD patterns. Besides, all membranes prepared using low GGA content could impart enhanced hydrophilic nature and permeation characteristics compared to pristine PPSU membranes. Moreover, greater thermal stability, surface roughness, and a noticeable decline in the mean pore size of the membrane were obtained.
Crystal Chemistry of Six Grossular Garnet Samples from Different Well-Known Localities
Authors: Antao Sytle M.
Published: July 2021

Two isotropic grossular (ideally Ca3Al2Si3O12) samples from (1) Canada and (2) Tanzania, three optically anisotropic grossular samples (3, 4, 5) from Mexico, and one (6) anisotropic sample from Italy were studied. The crystal structure of the six samples was refined in the cubic space group Ia3¯d, using monochromatic synchrotron high-resolution powder X-ray diffraction (HRPXRD) data and the Rietveld method. The compositions of the samples were obtained from electron microprobe analyses (EPMA). The HRPXRD traces show a single cubic phase for two isotropic samples, whereas the four anisotropic samples contain two different cubic phases that were also resolved using X-ray elemental line scans, backscattered electron (BSE) images, and elemental maps. Structural mismatch from two cubic phases intergrown in the birefringent samples gives rise to strain-induced optical anisotropy. Considering the garnet general formula, [8]X3[6]Y2[4]Z3[4]O12, the results of this study show that with increasing unit-cell parameter, the Y-O distance increases linearly and rather steeply, the average  distance increases just slightly in response to substitution mainly on the Y site, while the Z-O distance remains nearly constant. The X and Z sites in grossular contain Ca and Si atoms, respectively; both sites show insignificant substitutions by other atoms, which is supported by a constant Z-O distance and only a slight increase in the average  distance. The main cation exchange is realized in the Y site, where Fe3+ (ionic radius = 0.645 Å) replaces Al3+ (ionic radius = 0.545 Å), so the Y-O distance increases the most.
Mineral Geochemistry of Basaltic Rocks from IODP Expeditions 334 and 344: Implications for Magmatic Processes of Cocos Ridge Segment Being Subducted Beneath the Middle America Trench
Authors: Yan Quanshu , Ge Zhenmin
Published: July 2021

The Cocos Ridge, which is subducted beneath the Central American Volcanic Arc, has a complex tectonic evolution history due to plume-ridge interaction between the Galápagos plume and the Cocos—Nazca spreading center. This study presents major and trace element analyses of plagioclase and clinopyroxenes hosted by Cocos Ridge basaltic rocks that were drilled in three holes (U1381A, U1381C and U1414A) of Sites U1381 and U1414 on the Cocos Ridge close to the Middle America Trench during the Integrated Ocean Drilling Program (IODP) Expeditions 334 and 344. The results show that (1) plagioclases are mainly bytownite and labradorite with subordinate andesine, which are enriched in light rare earth elements (LREE) and some large-ion lithophile elements (LILE) and exhibit marked positive Eu anomalies; and (2) that clinopyroxenes are augites, which are depleted in highly incompatible elements such as LREE and LILE, have nearly flat heavy rare earth elements patterns (HREE) and lack Eu anomalies in chondrite-normalized rare earth element (REE) diagrams. During the ascent to the surface, the primary magmas experienced fractional crystallization of plagioclase, clinopyroxene, Ti-Fe oxides and possibly olivine (complete replacement of olivine by secondary minerals). The crystallization temperatures of plagioclase phenocrysts and microlites are 1050 to 1269 °C, and 866 to 1038 °C, respectively, and the pressures of plagioclase phenocrysts are 0.3–0.7 GPa. The crystallization temperatures of clinopyroxene phenocrysts/micro-phenocrysts is 1174–1268 °C, similar to those of plagioclase phenocrysts, suggesting some of clinopyroxene and plagioclase phenocrysts cotectic crystallized during early stage of magmatic evolution. In addition, the equilibrium pressures of clinopyroxene phenocrysts/micro phenocrysts are 0.02–0.97 GPa, implying that the clinopyroxene started to crystallize within the mantle, and magma evolution has undergone an early crystallization stage with clinopyroxene and no plagioclase.
Revealing Artists’ Collaboration in a 14th Century Manuscript by Non-Invasive Analyses
Authors: Perino Michela , Pronti Lucilla , Di Forti Lucrezia Gaia , Romani Martina , Taverna Cecilia , Massolo Lola , Manzari Francesca , Cestelli-Guidi Mariangela , Nucara Alessandro , Felici Anna Candida
Published: July 2021

In the last decades, the working methods of late medieval illuminators have been widely discussed by art historians and codicologists. Non-invasive analyses are able to characterise the painting methods of illuminators as well as investigate artistic collaborations among them. The aim of this study was to characterise the painting palettes and techniques of different artists who illuminated two leaves from an early fourteenth century manuscript. The analyses were carried out with non-invasive and portable techniques such as Energy Dispersive X-ray Fluorescence (ED-XRF) spectrometry, Fiber Optics Reflectance Spectroscopy (FORS) and Raman spectroscopy. The paper highlights the differences among three rich and varied palettes and examines the pigments ultramarine, azurite, verdigris, earths, orpiment, red lead, vermillion, lead white, yellow lake, indigo, brazilwood and lac, used independently or in mixtures. We have demonstrated the effectiveness of non-invasive analyses as a tool to differentiate hands of artists who have worked on the same page. Furthermore, the comparison with analyses carried out on leaves attributed to the workshop of Pacino di Bonaguida allows to investigate in-depth the production of the main illuminators active in Florence at the dawn of the Renaissance.
Nanomaterials for Modulating the Aggregation of β-Amyloid Peptides
Authors: Huang Yaliang , Chang Yong , Liu Lin , Wang Jianxiu
Published: July 2021

The aberrant aggregation of amyloid-β (Aβ) peptides in the brain has been recognized as the major hallmark of Alzheimer’s disease (AD). Thus, the inhibition and dissociation of Aβ aggregation are believed to be effective therapeutic strategiesforthe prevention and treatment of AD. When integrated with traditional agents and biomolecules, nanomaterials can overcome their intrinsic shortcomings and boost their efficiency via synergistic effects. This article provides an overview of recent efforts to utilize nanomaterials with superior properties to propose effective platforms for AD treatment. The underlying mechanismsthat are involved in modulating Aβ aggregation are discussed. The summary of nanomaterials-based modulation of Aβ aggregation may help researchers to understand the critical roles in therapeutic agents and provide new insight into the exploration of more promising anti-amyloid agents and tactics in AD theranostics.