bluuebunny/crossref_metadata_2025 huggingface dataset:
Prevalence of hearing loss in schoolchildren: populational study and global estimates
Authors: Chibisova S. S. , Alsharjabi E. , Zyuzin A. S. , Markova T. G. , Popadyuk V. I. , Tavartkiladze G. A.
Published: October 2022

Introduction. Hearing impairments in schoolchildren affects learning and communication. Reliable data on hearing loss prevalence in this group are necessary for planning the audiological care.

Aim. To compare data from a  population-based study of  the hearing loss prevalence in  schoolchildren and estimates from the Global Burden of Disease (GBD) study in the Republic of Yemen.

Materials and methods. Data extraction was performed from the GBD database on the prevalence of bilateral hearing loss >20 dB among children aged 5–9 years in the Republic of Yemen. A two-stage study of hearing loss prevalence among primary school students aged 6–9 years in Sana’a, Republic of Yemen, in a sample of 2200 children using screening audiometry at 20 dB at 0.5, 1, 2, and 4 kHz is school settings, followed by tonal threshold audiometry and tympanometry in a specialized clinic. Hearing loss was assessed as unilateral or bilateral when hearing thresholds were higher than 25 dB.

Results. According to GBD estimates, bilateral hearing impairment in this population is 2.2%, including 1.4% of mild degree. According to the results of a Yemenian population study, mild and moderate hearing impairment was detected in 10.6%, of which 6.8% – unilateral, 3.8% – bilateral hearing loss. There were no cases of severe or profound hearing loss. The prevalence of otitis media with effusion was 6%, chronic suppurative otitis media – 1.8%, sensorineural hearing loss – 1.6%.

Conclusion. Bilateral hearing impairments occur in 2.2–3.8% of primary school students, with unilateral impairments the prevalence is up to 10.6%. Of these, at least 65% have conductive hearing loss due to pathology of the middle ear. The data obtained will improve the efficiency of ear and hearing care for schoolchildren.
Correct treatment regimen and inhalation technique are the components of success in bronchial asthma in the era of COVID-19
Authors: Belotserkovskaya Yu. G. , Romanovskikh A. G. , Smirnov I. P.
Published: October 2022

The goal of Asthma treatment is to achieve a controlled condition, that is, to minimize the burden of symptoms and the risk of exacerbations. Many factors hinder the achievement of this goal: non-compliance with recommendations for drug therapy, the influence of concomitant diseases, the impact of triggers, low patient adherence to prescribed treatment, violation of inhalation technique. In general, there is no significant difference in the risk of hospitalization or mortality due to COVID-19 in patients with Asthma. At the same time, studies show that non-allergic Asthma, severe Asthma, Asthma in combination with obesity, lack of adequate basic therapy can create the greatest risk of infection and severe clinical outcomes of COVID-19. Asthma can be a predictor of a prolonged intubation period in severe respiratory failure during COVID-19, especially in people younger than 65 years. GINA experts agree that during a pandemic, it is especially important that patients with Asthma continue taking basic therapy, including inhaled corticosteroids (ICS), as prescribed by the recommendations. ICS therapy in combination with long-acting β2-agonists (LABA) is the main pharmacological method of treating moderate and severe Asthma in adolescents and adults. A single inhaler regimen with the use of a combination of ICS/formoterol is associated with a lower risk of severe exacerbations compared with supportive treatment of ICS/LABA in combination with SABA on demand. Studies show that the technique of inhalation maneuver can significantly affect the success of therapy. A wide variety of DPI causes problems with the choice and use by patients.
Some features of the course of viral pneumonia in obesity
Authors: Minakov A. A. , Salukhov V. V. , Kharitonov M. A. , Zagorodnikov G. G. , Voloshin N. I.
Published: October 2022

Intriduction. In the last decade, conflicting data has appeared that the presence of obesity in patients with several diseases not only does not worsen, but even improves their prognosis, which is called the “obesity paradox”. The role of elevated body mass index in patients with coronavirus pneumonia (COVID-19) remains unclear.

Aim. To study the features of the course of pneumonia in young and middle-aged men depending on the body mass index.

Materials and methods. A retrospective analysis has investigated and it included 451 young and middle-aged men who underwent inpatient treatment for COVID-19 pneumonia. Patients were randomized according to body mass index into groups: normal nutrition (N), overnutrition (On), obesity (Ob). Clinical and laboratory parameters were assessed using statistical analysis.

Results and discussion. In patients with obesity, the causative agent of pneumonia was detected in 91.9% of cases, in contrast to group N (65.75%). At the onset of pneumonia, group Ob differed significantly from group N in terms of erythrocyte sedimentation rate (17 versus 9 mm/h), C-reactive protein (18.3 versus 7.2 mg/l), D-dimer (304 versus 230 ng/ml), glycemia (6.2 versus 5.2 mmol/l), lymphocytes 9 (1.3 versus 1.5 × 109/l). In the dynamics in the group Ob, in comparison with the group N, there is a higher level of platelets (307 versus 1 × 109/l), neutrophils (6.3 versus 3.7 × 109/l), monocytes (0.8 versus 0.6 × 109/l) and a smaller number of lymphocytes (1.4 versus 2.0 × 109/l). It was revealed that the lymphocytic index and the index of the ratio of lymphocytes to monocytes in dynamics significantly increase in group N (from 0.5 to 0.7 and from 3.5 to 4.5, respectively), in group On only the lymphocyte index significantly increases (from 0.4 to 0.5), in the obesity group they do not change (from 0.4 to 0.5 and 3 from.0 to 2.7, respectively). The greatest need for respiratory support had group Ob (21.1%) in comparison with GNP (6.0%).

Conclusions. The level of adipose tissue in the body has a direct impact on the course of pneumonia.
Bronchial asthma: focus on adherence to inhaled therapy
Authors: Fesenko O. V.
Published: October 2022

The rising incidence of the disease, severe exacerbations, and risks of death make bronchial asthma an urgent public health problem. Effective control of the disease is recognised as the main goal of modern therapy. Studies conducted in our country and abroad show a low level of bronchial asthma control in most patients. An important condition for achieving control is the patient’s adherence to therapy. Higher adherence rates and, consequently, improved quality of life have been recorded in patients receiving baseline therapy, which involves a single inhalation per day. The long-acting combination powder inhaler fluticasone furoate/ vilanterol is one of the modern drugs with proven efficacy and safety. The drug has been shown to significantly improve lung function and reduce the frequency of asthma exacerbations. Of particular note are the results of a randomised clinical trial carried out in real (everyday) clinical practice. This form of study is non-selective, i.e. it includes a wide group of patients regardless of severity, comorbidities and lifestyle. This approach was used in a study called the Salford Lung Study. It included patients with bronchial asthma who were receiving ongoing maintenance therapy with inhaled glucocorticosteroids or combinations thereof from primary care centres. The study lasted for 52 weeks. The first group consisted of patients treated with the fluticasone furoate/vilanterol combination. Group 2 patients continued to receive baseline therapy. The best response was observed with the fluticasone furoate/vilanterol combination. It was maintained in all subgroups analyzed and was independent of smoking status, baseline control reduction, and number of severe exacerbations in the past year. Adherence to treatment is improved by a single dose and a convenient, intuitive means of delivery. The inhaler requires minimal coordination, is activated with a single movement and has an easy-to-understand dose counter.
Influence of exogenous and endogenous factors on lung function in children and adolescents with cysistic fibriosis with genetic variant F508DEL in homozygous state
Authors: Shadrina V. V. , Furman E. G. , Starinova M. A. , Voronkova A. Yu. , Sherman V. D. , Zhekaite E. K. , Kondratyeva E. I.
Published: October 2022

Introduction. In cystic fibrosis (CF), a thick secret with pathogenic microflora in the respiratory tract and other factors lead to a decrease in lung function, repeated hospitalizations and a decrease in the quality of life of patients.

Aim. To evaluate the influence of endogenous and exogenous factors on lung function in children and adolescents with CF with the F508del variant in the homozygous state.

Materials and methods. Spirometry parameters were analyzed in 379 patients with the F508del variant in the homozygous state at the age of 6–18 years according to the National Register of CF Patients 2019.

Results. In children with CF at the age of 6–10 years, FEV1 and FVC were significantly higher than in children aged 11–14 and 15–18 years. P. aeruginosa and Achromobacter spp. infection had a negative effect on lung function. A weak correlation was found between nutritional status and respiratory function (for FEV1 r = 0.229; p <0.001; for FVC r = 0.206; p <0.001). In the Southern, Urals, and North Caucasian federal districts of the Russian Federation, the parameters of respiratory function in patients were significantly lower than in the Central Federal District.

Conclusions. For a group of patients, carriers of the F508del genotype in the homozygous state, factors that negatively affect respiratory function were identified: adolescence, low nutritional status, respiratory tract infections P. aeruginosa, Achromobacter spp., Burkholderia cepacia complex, liver cirrhosis with portal hypertension and features of organizational assistance to patients. Some factors are correctable in the organization of preventive measures, which can have a positive impact on reducing the rate of damage to the bronchopulmonary system. Regular monitoring and timely correction of nutritional status, monitoring of respiratory tract infections, their prevention and timely completion of eradication therapy courses are required. Adolescent patients require special attention.
La construcción de un eco-frente en la región fronteriza de la Selva Maya
Authors: Laako Hanna , Ramos Muñoz Dora , Pliego Alvarado Esmeralda , Marquez Beula
Published: October 2022

El concepto de eco-frente analiza las acciones de actores ecológicos con la finalidad de considerar la manera en que contribuyen para transformar los territorios de alta biodiversidad. Los eco-frentes son apropiaciones espaciales y discursivas que evolucionan en etapas históricas. Este artículo analiza el caso de la Selva Maya como un eco-frente a partir de la década de 1970. La Selva Maya es un concepto construido por actores ecológicos para conservar selvas tropicales que cubre a la región fronteriza entre México, Guatemala y Belice. Se analizan materiales de primera mano que demuestran cómo la construcción del concepto ha transformado la región fronteriza en una eco-región paisajística para la conservación de selvas tropicales. Si bien, su apropiación de lo maya en su sentido científico y turístico refiere a la construcción de regiones fronterizas internacionales bioculturales, deja abierta la cuestión de derechos indígenas, su contexto multicultural, y de multiespecies.
Analisis Algoritma Pergantian Cache Pada Proxy Web Server Internet Dengan Simulasi
Authors: Nurwarsito Heru
Published: October 2022

Pertumbuhan jumlah client internet dari waktu ke waktu terus bertambah, maka respon akses internet menjadi semakin lambat. Untuk membantu kecepatan akses tersebut maka diperlukan cache pada Proxy Server. Penelitian ini bertujuan untuk menganalisis performansi Proxy Server pada Jaringan Internet terhadap penggunaan algoritma pergantian cache-nya.

Analisis Algoritma Pergantian Cache Pada Proxy Server didesain dengan metoda pemodelan simulasi jaringan internet yang terdiri dari Web server, Proxy server dan Client. Proxy Server menggunakan model hirarki dan hubungan antar Proxy Server dalam tingkatan yang sama (sibling). Akses permintaan dari Client ke Proxy Server dihubungkan pada tingkat paling bawah (Level 1). Pada saat Cache penuh, maka diperlukan penghapusan obyek data yang telah tersimpan, penghapusan ini diatur berdasarkan Algoritma LRU, LFU, LFU-Aging dan GDSF.

Dari hasil uji coba menunjukkan bahwa algoritma GDSF mempunyai Hit Ratio dan Byte Hit Ratio yang paling tinggi. Pada model hirarki dua tingkat tanpa sibling, tidak banyak berpengaruh terhadap performansinya. Pada model hirarki dengan satu tingkat atau dua tingkat dengan sibling dua buah proxy akan meningkatkan performansi berkisar 87-91%. Pada model hirarki satu tingkat dengan sibling antar tiga buah dan empat buah proxy yang membentuk jaringan mesh maka akan meningkatkan performansi menjadi 98-99% .Pada model hirarki dengan dua tingkat dengan sibling minimal tiga buah proxy yang membentuk mesh, maka akan sangat mengurangi bandwith yang keluar bisa mencapai 95%.
Manajemen Sumberdaya dalam Strategi Pengelolaan Limbah Medis Rumah Sakit Islam Kota Malang di Masa Pandemi Covid-19
Authors: Nastiti Bahagia
Published: October 2022

Resource management in the management of medical waste is a cruicial issue in the midst of Covid-19 pandemic. This study aims to analyze the management of hazardous and toxic waste management resources at the Islamic Hospital (RSI) Malang City by adopting descriptive research through a qualitative approach. Findings of this study found a discrepancy between the Standard Operating Procedures (SOP) and the realization of activities in the field, especially when there was a surge in Covid-19 patients due to the rapid increase in waste generation. This leads the delays in transportation which results in the accumulation of waste. Delays in transporting waste has potential to cause environmental pollution. Hence, it is necesarry to conduct a review of SPO to deal with the threat of Covid-19 spike in the future.
Uncertainty in the education sphere of Ukraine: paths to stabilization
Authors: Horbov Vladyslav , Horbova Yulia
Published: October 2022

The article is dedicated to understanding uncertainty as a state in which social systems exist in crisis conditions. Today, the need to conduct scientific research to determine the factors and ways that can overcome the state of uncertainty and lead to stabilization is extremely urgent. As an illustration of such phenomena, the system of higher education was chosen, which underwent significant systemic transformations and changes in the daily behavioral practices of various subjects of the educational process in the crisis conditions of the COVID-19 pandemic. The main idea of the article is based on an attempt to record changes in the educational environment in conditions of social uncertainty, to study changes in established behavioral practices of social subjects and the emergence of qualitatively new phenomena that will require further study. Based on empirical research, the authors identify the factors that contribute to the transition of the education system from a state of crisis to a certain stabilization. Such factors include innovative and technological factors (adaptation of the educational environment with the help of various technological support), mental adaptation to unusual everyday practices (remote learning, new forms of communication, increased psycho-emotional stress, etc.). Factors that have a partially destabilizing nature and exacerbate uncertainties are recorded: the difficulty of identifying students, problems in making socially adequate management decisions at the organizational level, limitations of compensatory mechanisms for adaptation of social subjects to a state of uncertainty. The need for scientific research to study the impact of social and technological innovations on the stabilization of social systems, in particular the system of higher education, is being updated.
Recommendations for Successful Implementation of the Use of Vocal Biomarkers for Remote Monitoring of COVID-19 and Long COVID in Clinical Practice and Research
Authors: Fischer Aurelie , Elbeji Abir , Aguayo Gloria , Fagherazzi Guy
Published: October 2022

The COVID-19 pandemic accelerated the use of remote patient monitoring in clinical practice or research for safety and emergency reasons, justifying the need for innovative digital health solutions to monitor key parameters or symptoms related to COVID-19 or Long COVID. The use of voice-based technologies, and in particular vocal biomarkers, is a promising approach, voice being a rich, easy-to-collect medium with numerous potential applications for health care, from diagnosis to monitoring. In this viewpoint, we provide an overview of the potential benefits and limitations of using voice to monitor COVID-19, Long COVID, and related symptoms. We then describe an optimal pipeline to bring a vocal biomarker candidate from research to clinical practice and discuss recommendations to achieve such a clinical implementation successfully.
The Roles of Organizational Politics and Procedural Fairness in the Relationship between Performance Evaluation Systems and Budget Gaming Behavior
Authors: SeTin SeTin , Sembel Roy , Sudibyo Yvonne Augustine , Purwanti Ari
Published: October 2022

This study investigates the relationship between performance evaluation systems and budget gaming behavior. Specifically, it examines the mediating role of organizational politics and procedural fairness. Data collection was conducted by a questionnaire survey of managers of go-public manufacturing companies in Indonesia. Based on a sample of 128 responses, the partial least squares results indicate that general political behavior, the politics of pay and promotion policies, and procedural fairness significantly mediate the non-financial measures and budget gaming relationship. In contrast, the results indicate that the mediating effects of organizational politics and procedural fairness on the relationship between relative performance measures and budget gaming behavior are generally insignificant. This study supports the goal setting theory and the organizational justice theory, and contributes to the management control system literature by recognizing the importance of performance evaluation systems, the importance of understanding political behavior and the perception of fairness to overcome budget gaming behavior. This study provides assurance that organizations can reduce budget gaming behavior through using non-financial measures or incentives.
Insiders, Outsiders and Performance of Vietnamese Firms
Authors: Beason Richard , Tran Tu Thi Thanh , Dao Dong Phuong , Nguyen Hong Minh
Published: October 2022

The consensus in the finance literature is that a large proportion of inside ownership (defined as greater than 5% share ownership by non-institutional holders, managerial holdings, founding family holdings, cross-shareholdings by affiliated firms and ownership by creditors) tends to be associated with more unsatisfactory performance (as measured by ROE or ROA) when compared to firms with lower inside ownership, all else equal. However, this need not be the case if insiders act as monitors of the firm and have the same interest in returns as outsiders.  Ownership structure and firm level financial performance have not been widely studied in Vietnam.  Using data from 729 listed firms in Vietnam for 2018, we test the hypothesis that greater insider ownership has a negative impact on firm performance. We found that Vietnam's insiders play a monitoring role, exercising their relative power to ensure the firm's profitable functioning. These findings are inconsistent with research on Japanese groupings, as well as other findings. The Vietnamese stock market does not appear to be negatively affected by insider influence; indeed, insiders appear to act as positive monitors.
Phase Transfer Catalyzed Preparation of 4-Methylbenzenesulfonyl Imidazole for Regioselective Synthesis of Mono-6-(4-methylbenzenesulfonyl)-β-cyclodextrin
Authors: Muderawan I Wayan , Mudianta I Wayan , Wiastuti Giri Made Kurnia
Published: October 2022

The preparation of 4-methylbenzenesulfonyl imidazole by using triethylamine as an effective phase‐transfer catalyst (PTC) under mild biphasic conditions has been studied intensively. The method can be used for large-scale preparation with high purity and high yield of 4-methylbenzene-sulfonyl imidazole. The result in 4-methylbenzenesulfonyl imidazole has been successfully applied for the regioselective synthesis of mono-6-(4-methylbenzenesulfonyl)-β-cyclodextrin in an aqueous medium. This synthetic methodology concept, together with the synthetic versatility of PTC, provides a general and reliable general strategy for the practical and industrial regioselective synthesis of highly valuable mono-6-(4-methylbenzenesulfonyl)-β-cyclodextrin as a key intermediate for the single functional isomer mono-substituted cyclodextrin derivatives. As characterized by FTIR, NMR and mass spectrometry, mono-6-(4-methylbenzenesulfonyl)-β-cyclodextrin was obtained in high purity.
Role of Temperature and Time Exposure for Controlled and Accelerated Synthesis of Graphene Oxide Using Tour Method
Authors: Chasanah Uswatul , Trisunaryanti Wega , Oktaviano Haryo Satriya , Triyono Triyono , Fatmawati Dyah Ayu
Published: October 2022

Synthesis of graphene oxide (GO) with the Tour method has been studied. In this procedure, phosphoric acid was mixed with sulfuric acid in the ratio of 1:9, and then potassium permanganate and graphite with the ratio of 6:1 was added in an ice bath at the variation of oxidation times of 1, 7 and 24 h and temperatures of 40, 50 and 60 °C. The GOs were characterized by UV–Visible spectroscopy, Fourier Transform InfraRed (FT-IR) spectroscopy, X-ray Diffraction (XRD), Scanning Electron Microscopy-Energy Dispersive X-Ray (SEM-EDX), and Transmission Electron Microscopy (TEM). The results show that the GO oxidized at 40 °C for 7 h (GO-7-40) has been successfully formed indicating that GO-7-40 is the most efficient GO. The GO-7-40 is characterized by a peak at 2θ = 10.89° in the XRD diffractogram, resulting calculation of the average distance between graphene layer (d) of 0.81 nm. The average number of graphene layers (n) is 4, the oxidation level (C/O) is 1.50 according to EDX data, λmax at 226 nm attributes to π→π* transitions of C=C bond in UV-Vis spectrum, and the functional groups such as O-H, C=C, C-OH, and C-OC are observed in FT-IR spectrum.
Synthesis, Thermal Analysis, and Thermodynamic Properties Study of New Quinoline Derivative and Their V(IV), Co(II), and Cu(II) Complexes
Authors: Aldoghachi Raghad Jawad Kadhim , Aldoghachi Faris Abdulridha Jassim , Alsalim Tahseen Abdul Qader , Ibrahim Mohd Lokman
Published: October 2022

A new ligand (E)-2-((2-chloro-6-methylquinoline-3-yl)methylene)-N'-((E)-(2-chloro-6-methylquinoline-3-yl)methylene)hydrazine-1-carbothiohydrazide (QH) was prepared by reacting hydrazine hydrate with carbon disulfide to yield thiocarbohydrazide. The thiocarbohydrazide in the second step was treated with a quinoline derivative 2-chloro-6-methylquinoline-3-carbaldehyde to yield the ligand. The ligand was identified by spectroscopic techniques FTIR, 1H-NMR, and 13C-NMR. Next, vanadium (V), cobalt (Co), and copper (Cu) complexes were prepared in the [M:L] ratio of 1:1 (QV, QCo, QCu). The complexes were characterized using FTIR, ESI, magnetic susceptibility, and molar conductivity. The thermal analysis (TGA) of V(IV), Co(II), and Cu(II) complexes were studied. The activation thermodynamic parameters, such as the energy of activation, enthalpy, entropy, and free energy change of the complexes, were evaluated, and the stabilities of the thermal decomposition of the complexes were discussed.
Ecological Study Along the Highlands Highway in Papua New Guinea
Authors: Ha Nguyen Thu
Published: October 2022

This ecological survey carried out along the Highlands Highway (71 locations-bridges) between Erap Bridge in Morobe Province to Whagi Bridge, Western Highlands Province. Data and information collection involved physical site observations and informant interviews. The survey used the capture-release method for insects, invertebrates, fish, and plankton; flyover counts were used for birds and informant interviews for mammals and other animals of interest. Terrestrial ecosystem: Common fauna included invertebrates such as Eurema hecabe, Danaus plexippus, Plutella xylostella, and other types of butterflies, Anisoptera, Apis cerena, and black ants (Fomicidae). Vertebrates such as sparrows (Passeridae), willy wagtail (Rhipidura leucophrys), eagle (Hieraaetus weiskei), kingfisher (Alcedinidae), mountain cuscus (Phalanger carmelitae), tree kangaroo (Dendrolagus goodfellowi) and Princess Stephanie’s Astrapia (Astrapia. Stephaniae). Flora across the highlands province commonly appeared bamboo, casuarina oligodon (she-oak), Ficus dammaropsis, coffee, elephant grass (Pennisetum purpureum), cow grass (Axonopus compressus), rain tree (Samanea saman), Piper adancum and banana. In contrast, common and significant flora along plain region included casuarina, pine, leucaena, bamboo, and other anthropogenic grasses, Piper adancum, sunflower (Helianthus annuus), Northofagus grandis, and Ficus. Aquatic ecosystem: Aquatic fauna along the highlands region included carp (Cyprinidae), tilapia (Oreochromis mossambica), juvenile fish, freshwater prawns (Palaemonidae), trout (Oncorhynchus mykiss), and catfish (Arius spp) while aquatic fauna of coastal province comprised of invertebrates like pond skaters, water beetle and tadpoles and invertebrates such as rainbow trout and tilapia. Aquatic flora was limited to green algae at a few locations in the highlands provinces where the water was stagnant or had human impacts, but it was primarily green and brown algae in the plain area. We also found Dendrolagus goodfellowii as an endangered species, while Phalanger carmelitae, Astrapia stephaniae, and Northofagus grandis are endemic but classified as the least concern. The findings indicated modification of habitats throughout the Highlands Highway. The absence of native and endemic species was also noted in most of the locations. Only six sites revealed some primary and secondary forests and vegetation.
Prevalence of indicative symptoms of cognitive alterations in hospitalized elderly and associated factors
Authors: Bordin Danielle , Weigert Amanda de Barros , Taques Taís Ivastcheschen , Garbuio Ana Paula , Bordin Rodrigo , Bernart Maria de Lourdes
Published: October 2022

Aging causes both physical, psychological and social changes that, when added to situations which do not favor healthy aging, can lead to complications such as cognitive impairment. The objective was to evaluate the prevalence of symptoms indicative of cognitive alterations in hospitalized elderly and associated demographic factors. This is a cross-sectional, quantitative study carried out with 673 elderly people hospitalized in the 2020-2021 period. A demographic questionnaire and questions that investigated the cognitive condition were applied. Absolute and relative frequency and chi-square test were performed, considering the variable “Set of symptoms indicative of cognitive alteration” as dependent. It was found that 50.2% of the elderly have forgetfulness observed by family and friends; 29.7% reported that this forgetfulness has worsened in recent months and 30.0% have difficulty maintaining attention and a connected conversation. In relation to the elderly who presented a set of symptoms indicative of cognitive alteration, a prevalence of 17.5% was found. It was found that elderly people aged among 70 and 79 years and 80 years or more had a risk ratio of 1.11 and 1.31, respectively, of having symptoms indicative of cognitive impairment compared to elderly people aged among 60 and 69 years. (p<0.001) and widowers had a risk ratio of 1.19 for having symptoms indicative of cognitive impairment, to the detriment of married or in a stable relationship (p<0.001). It is concluded that the prevalence of a set of symptoms indicative of cognitive impairment in hospitalized elderly was high and associated to the oldest and widowed.
Inelastic Behaviour and Strength of Steel Beam-Columns with Applied Torsion
Authors: Kumar Nitin
Published: October 2022

Abstract: This dissertation presents the outcome of an experimental and theoretical study o f the inelastic behavior and strength of steel beam-columns with applied torsion. Although the international steel design specifications contain interaction relations for biaxially loaded beam-columns, the influence of applied torsion on such members has been completely ignored in the past. A series of hollow square section steel members are tested using an apparatus specially designed to apply torsion in the presence of an axial load and biaxial bending. The theoretical analysis involves formulation of a system of materially nonlinear differential equations and their solution based on a finite integral formulation. The predicted member response agreed quite well with the experiments. A set of new yield limit and strength interaction expressions are then developed which include the influence of applied torsion. In addition, beam-column interaction relations used in Australia, Canada, China, Great Britain, Japan, Russia, the U.S. and Eurocode are modified to account for applied torsion. Finally, this dissertation presents new load-moment-torsion interaction relations for possible adoption in the international steel design specifications.
Voltage Feed-Forward Controlled 75W Forward Converter with Type-2 Compensation and Protection Circuits
Authors: N Kalpana , Kulkarni Shubha , Singh B K
Published: October 2022

Abstract: In recent years, DC-DC converters find many applications in low to medium power range. The isolated converters are used in medium power application such as military, electric vehicle (EV) and space industries since they provide isolation between input and output and protection from input side faults. These are made capable of providing a specified output voltage by managing the PWM pulses delivered to the switching device's gate. This paper presents use of voltage feed-forward method which helps in suppressing effect of input line harmonics and disturbances and gives regulated output voltage. The converter is operating at a switching frequency of 140 kHz and behaviour of switching device is not taken into consideration. The converter has protection circuits like over voltage protection (OVP), over current protection (OCP) on input and outputs, under voltage protection (UVP) which protects from abnormal operating condition. The design and simulation results of the feed-forward technique with type-2 compensation and protection circuits are discussed.
Formation of Innovative Strategies for the Development of Mining Enterprises in the Metallurgical Complex
Authors: Kurbanova Mekhriniso
Published: October 2022

Abstract: The article studies the theoretical foundations for the formation of innovative strategies for the development of mining enterprises of the metallurgical complex on the example of the Navoi Mining and Metallurgical Combine. On the basis of the studied data, the problems of the activities of the Navoi Mining and Metallurgical Combine in the formation of an innovative development strategy were identified and proposals were developed to help eliminate shortcomings.
Use of Distance Learning Technologies in the Higher Education System
Authors: Xakimov Muxammadali
Published: October 2022

Abstract: Distance learning is defined by a combination of pedagogical and information technologies. Modern computer networks are able to provide knowledge transfer and access to a variety of educational information on an equal basis, and sometimes even more effectively than traditional learning tools. However, for their effective use in the process of acquiring knowledge and forming intellectual skills, a coordinated development of technological, informational, and didactic and methodological components of the educational process is necessary.
Competencia y transmisión de precios en la producción de nopal en milpa alta, ciudad de México y Tlalnepantla, Morelos.
Authors: Rodríguez Medina Oscar , Torres Torres Felipe , Alvarado Lagunas Elías
Published: October 2022

El objetivo de investigación es determinar si existen prácticas anticompetitivas en la producción de nopal entrela zona productora de Tlalnepantla, Morelos y la de Milpa Alta, Ciudad de México. La hipótesis es que lascantidades de producción de las zonas de producción de Milpa Alta y Tlalnepantla determinan el proceso deformación de precios en ambos mercados. Los procedimientos fueron los modelos de vectores autorregresivos(VAR) y modelo corrector de errores (VECM) aplicados a dos subperiodos, 2000-2005 y 2006-2017. Losresultados indican que la simetría en la transmisión de precios se modificó considerablemente entre ambosperiodos, es decir, que los coeficientes de los precios y cantidades de Morelos del primer modelo (0.54317y -0.00602) indican que la relación de precios entre zonas productoras no era simétrica y que la producciónmorelense afectaba de manera marginal al proceso de formación de precios entre zonas. No obstante, los parámetrosobtenidos en los modelos del segundo periodo indicaron una relación prácticamente simétrica, con uncoeficiente de 0.980452 para los precios de Morelos. Asimismo, el coeficiente de las cantidades de producciónde Morelos pasó de marginal a considerable (-0.635184); lo que implica efectos de poder de mercado de unasobre la otra.
Is there a model for symbolic revolution? Bourdieu’s theory in Manet and a comparison with a case study: the Generation of 1914 in Spain
Authors: Costa Delgado Jorge , Moreno Pestaña José Luis
Published: October 2022

The courses that Bourdieu dedicates to Manet help to better understand the link between cultural production, political position and social trajectory. Nevertheless, Bourdieu does not always fully clarify his position. In this article, first we will clarify what Bourdieu considers to be a model for symbolic revolutions. To do so, Manet's courses are revisited and their links with Bourdieu’s work in general and, more specifically, with his sociology of philosophy are made explicit. After that, we will examine Bourdieu's assertions about scholasticism or academicism in the sociology of culture, its importance in symbolic revolutions, and how his proposal encourages a specific view on the history of cultural productions, especially the philosophical ones. Then, Bourdieu's model of symbolic revolution will be tested by comparing it with a study with statistical treatment of data in a different and significant historical context: the Generation of ‘14 in Spain. Finally, we will propose some nuances and developments to Bourdieu's model based on the conclusions of that study.
Avaliação do ensino da ética, bioética e deontologia na formação do fonoaudiólogo do Rio Grande do Sul sob o olhar docente
Authors: Pereira de Souza Tiago , Gomes Erissandra
Published: October 2022

A ética enquanto atividade reflexiva perpassa todas as esferas da nossa vida, entretanto, ainda carece de atenção a aplicação do seu ensino na formação dos profissionais da saúde. A partir disso, esse estudo do tipo descritivo exploratório de abordagem qualitativa, objetivou analisar o ensino da ética, bioética e deontologia na formação em Fonoaudiologia do Rio Grande do Sul, sob o olhar crítico dos docentes. Participaram da pesquisa 11 professores de seis Instituições de Ensino Superior responsáveis pelo ensino das temáticas elencadas no objetivo. O tratamento do conteúdo das falas foi feito por meio da construção do Discurso do Sujeito Coletivo (DSC). O estudo também buscou traçar um perfil do ensino, mapeando a distribuição de carga horária, períodos de disponibilidade das disciplinas, perfil docente, bibliografia utilizada, metodologias de ensino e formas de avaliação, sob um viés normativo. Os dados e informações apontaram para a necessidade do aumento da carga horária dedicada para as temáticas, aplicação interprofissional e interdisciplinar, presença de conteúdos transversais e da transversalidade como metodologia de ensino. O estudo também destaca a importância de atualização das bibliografias utilizadas, ressignificação do conteúdo apresentado para um viés crítico-reflexivo vinculado à prática e o rompimento com métodos tradicionais de ensino.
Parecer descritivo: a suficiência do relatório avaliativo do ensino fundamental I de Curitiba
Authors: Raimundo Jerry Adriano , Rodrigues Kerolaine Aparecida Oniesko
Published: October 2022

Mediante a queixa de alguns familiares e professores sobre o relatório avaliativo da escola, este artigo se valeu da seguinte questão direcionadora de pesquisa: O parecer descritivo do ensino fundamental I (AVALIA), das escolas públicas de Curitiba atende a sua própria função? Para respondê-la, utilizou-se a abordagem mista (Grupo Focal e Escala). Os resultados indicaram que o Parecer Descritivo tem um desenvolvimento histórico apontado para a sistematização do documento, mas o seu modelo não é compreensível para a família (87,22%) ou para os profissionais (72,28%), de modo que os professores consideram que o documento não cumpre a sua função de documento escolar (61,22%).
Serie Ambiental Infantil Mapachín: legado de Mario Boza Loría. Génesis, evolución e impacto
Authors: Sonia Rojas Vargas
Published: October 2022

El artículo presenta la trayectoria de la educación ambiental infantil en la Universidad Estatal a Distancia (UNED) e ilustra cómo surgió a partir de la visión y liderazgo del Ing.  Mario Boza, primer director del Programa de Educación Ambiental (PEA), actualmente Centro de Educación Ambiental (CEA), con el objetivo de educar a la población sobre la protección de las áreas de conservación de la vida silvestre. El señor Boza Loría es pionero nacional de la educación ambiental; entre su legado se encuentra la Serie Ambiental Mapachín. Una serie de libros dedicada al desarrollo del pensamiento crítico, los valores positivos, las actitudes y el comportamiento de los niños frente a los problemas ambientales. A medida que la Serie continúa expandiéndose, se han establecido talleres ambientales educativos y recreativos para niños y educadores de todo el país. La Serie con más de 40 años, como publicación única en su género, ha cumplido integralmente con su cometido. Además, la Serie también constituye un aporte significativo a la literatura infantil en el país y está a la vanguardia de la educación ambiental de la niñez costarricense.
Mario A. Boza Loría (1942-2021): una vida dedicada a la protección de las áreas naturales y la educación ambiental
Authors: Jaime E. García González
Published: October 2022

Se resume la vida y la trayectoria en el campo ambiental de don Mario Boza, empezando por sus estudios y cursos de posgrado que le llevaron a interesarse en la protección de la naturaleza. Al finalizar su maestría ocupa el puesto de jefe del Departamento de Parques Nacionales y Vida Silvestre. También se menciona su destacada participación en la academia universitaria de tres universidades públicas, así como en otras organizaciones a nivel nacional e internacional. Además, se citan los múltiples galardones recibidos por su labor en pro de la salvaguarda de la naturaleza. Por último, se sintetiza el legado y los siete principales logros alcanzados en vida por don Mario en el área ambiental.
Multidisciplinary Team Role in Cochlear Implantation after Radiotherapy and Chemotherapy in Nasopharyngeal Carcinoma Patients
Authors: Liang Yue , Wei Fanqin , Zhuang Huiwen , Sun Jincangjian , Xie Liping , Chen Kaitian , Xiong Guanxia
Published: October 2022

Objectives: To explore the role of multidisciplinary team (MDT) in
perioperative safety and feasibility evaluation and postoperative effect
prediction of cochlear implantation (CI) in patients with bilateral
profound sensorineural hearing loss (SNHL) after radiotherapy and
chemotherapy for nasopharyngeal carcinoma (NPC). Methods: From 2017 to
2022, 11 patients with bilateral profound SNHL after radiotherapy and
chemotherapy for NPC received CI in our department. MDT formulated
diagnosis and treatment plan for all patients during their perioperative
period. The MDT participants were from the following departments:
otorhinolaryngology, radiology, radiotherapy, neurology, psychiatry,
anesthesiology, and audiology and speech rehabilitation. Several hearing
examinations were tested during the follow-up to dynamically observe the
effectiveness of the hearing and speech rehabilitation in the patients.
Results: Based on the MDT conclusion and decision, five patients
underwent routine CI, two patients underwent simultaneously extended
radical mastoidectomy and CI, and four patients underwent simultaneously
subtotal petrosectomy, external auditory canal elimination, mastoid
cavity obliteration by fat graft or musculoperiosteal flaps and CI. The
pure tone average of all 11 patients was 39.5 ± 5.0 dB and the average
speech discrimination score was 95.0 ± 9.7% postoperatively. One
patient underwent a second surgery for the cochlear electrode prolapsed
postoperatively. Conclusion: To some extent, CI is risky for patients
after chemoradiotherapy for NPC. However, the MDT approach can reduce
the risk fast, predict the auditory effect after implantation early, as
well as predict and prevent the occurrence of postoperative
complications. Therefore, MDT exerts a positive effect on the outcome of
the relatively safe and feasible application of CI in these patients.
Keywords: Multidisciplinary team, nasopharyngeal carcinoma, cochlear
implantation.
Cancer treatment-related cardiotoxicity: A focus on sacubitril/valsartan
Authors: hu feng , Yu Huajiong , Du Weiping , Chen Mengjia , Su Jia , Chen Xiaomin
Published: October 2022

Cardiotoxicity is the most dramatic complications of cancer therapies,
leading to halt in potentially life-saving anti-tumor treatment regimens
and a poor survival prognosis in a non-negligible percentage of
patients. Angiotensin converting enzyme inhibitors (ACEIs) and
β-blockers are effective in the treatment of the cancer therapy–related
cardiac dysfunction (CTRCD), while their roles in the prevention of
cardiotoxicity are unclear. Sacubitril/valsartan was advantageous over
ACEI in heart failure patients for further reduction of cardiovascular
death or heart failure re-hospitalization. However, there is short of
well-established testimony of its efficacy and safety in the prevention
and treatment of CTRCD in the cardio-oncology setting. Although some
small observational studies found a good performance of
sacubitril/valsartan in patients with CTRCD, large-scale prospective
clinical studies are required to confirm its excellent results. In this
paper, we review the potential benefit of sacubitril/valsartan in human
subjects with CTRCD.
Clinical outcomes of fetuses with chromosome 16 short arm copy number variants
Authors: Kang Jessica , Lee Chien Nan , Su Yi-Ning , Tai Yi-Yun , Chen Chi-Ling , Chen Han-Ying , LIN SHIN-YU
Published: October 2022

Objective: The short arm of chromosome 16 consists of several copy
number variants (CNV) that are crucial in neurodevelopmental disorders;
however, incomplete penetrance and diverse phenotypes after birth
aggravate the difficulty of prenatal genetic counseling. Design: Case
series. Setting: This study uses data from National Taiwan University
Hospital. Sample: We screened 15,051 pregnant women who underwent
prenatal chromosomal microarray analysis between July 2012 and December
2017. Methods: Patients with positive array results were divided into
four subgroups based on the type of mutation identified on screening
(16p13.3, 16p13.11, 16p12.2, and 16p11.2), and the maternal
characteristics, prenatal examinations, and postnatal outcomes of
different cases were reviewed. Main outcome measured: Postnatal
prognosis. Results: Chromosome 16 CNVs were identified in 35 fetuses,
including four with 16p13.3 CNVs, 22 with 16p13.11 CNVs, two with
16p12.2 microdeletions, and seven with 16p11.2 CNVs. Of the 35 fetuses,
17 delivered without early childhood neurodevelopmental disorders, three
developed neurodevelopmental disorders during childhood, and 11 were
terminated. Conclusion: Incomplete penetrance and variable expressivity
make prenatal counseling challenging. We report a few cases of de novo
16p CNVs without further neurodevelopmental disorders.
Importance of the relative epicardial connection locations and right-sided pulmonary vein isolation line for successful pulmonary vein isolation
Authors: Ishikura Masahiro , Kobori Atsushi , Sasaki Yasuhiro , Murai Ryosuke , Okada Taiji , Toyota Toshiaki , Taniguchi Tomohiko , Kim Kitae , Ehara Natsuhiko , Kinoshita Makoto , Furukawa Yutaka
Published: October 2022

Background: The presence of an epicardial connection (EC)
decreases the success rate of pulmonary vein isolation (PVI); however,
the effect of designing isolation lines has not been evaluated.
Objective: We sought to clarify the effects of designing an
anterior line for right-sided PVI considering the presence and location
of the EC. Methods: Seventy-four consecutive patients who
underwent initial catheter ablation for atrial fibrillation were
retrospectively included in this study. The presence of the EC was
determined by the left atrial (LA) activation map during right atrial
pacing, and patients were divided into EC-positive (n=23, 31%) and
EC-negative (n=51, 69%) groups. EC-positive patients were further
subdivided based on the EC location: on-the-line group, (EC on the PVI
line, n=11); inside-line group (EC on the pulmonary vein [PV] side,
n=10); and outside-line group (EC on the LA side, n=2). The PVI
parameters were compared among the three groups. Results: The
success rates of the first-pass isolation were comparable between the
EC-negative and EC-positive groups (70.6% vs. 60.9%, ns), but the
success rate was significantly higher in the on-the-line group than in
the inside-line group (91% vs. 20%, p=0.002). First-pass isolation was
successful in both patients in the outside-line group. Additional carina
ablation was required only in the inside-line group.
Conclusions: The association between the EC site and the
right-sided PV anterior isolation line affected the success rate of
first-pass isolation. For successful right-sided PVI, it is important to
consider the EC site when designing the PVI line.
An unexpected case of primary rectal diffuse large B-cell lymphoma
Authors: Bizid Sondes , Farhat Fatma Ben , Ghedira Hela , Bennaser Sonia , Chelly Beya , Stambouli Hela , Msadek Fehmi
Published: October 2022

Primary rectal lymphoma (PRL) is the rarest primary rectal cancer.
Clinical presentation is similar to rectal carcinoma. The role of
surgery is still controversial and the benefit of chemotherapy and
radiotherapy is not well established. We here report the case of female
patient suffering from PRL completely disappeared with chemotherapy.
Pseudo-metric modelling of distribution network state estimation based on CNN-BiLSTM network and customized HGGA algorithm
Authors: Qiu Rujia , Ding Jingya , Zhang Zhengkai , Han Pingping , Wu Hongbin , Wu Jiayu , Chen Siyuan
Published: October 2022

To address the insufficient configuration of real-time measurement
devices in distribution networks, a state estimation method for
distribution networks based on a CNN-BiLSTM network and a customised
HGGA algorithm is proposed. First, the historical data and real-time
data are used as the input of the CNN-BiLSTM network to obtain the
branch power pseudo measurement and load node injected power pseudo
measurement with high accuracy at the current moment. Second, the pseudo
measurement set of the input state estimation is determined using the
customised HGGA algorithm. Finally, the real-time measurement, pseudo
measurement, virtual measurement, and weight set are input into the
state estimation program to complete the real-time state estimation of
the distribution network based on the weighted least squares method.
Additionally, the proposed method is applied to the data fusion of
different measurement systems. Theoretical analysis and example
verification confirm that the proposed method can effectively improve
the accuracy of pseudo measurement modelling and state estimation
results.