bluuebunny/crossref_metadata_2025 huggingface dataset:
Reversal of Long-Term Weight Regain After Roux-en-Y Gastric Bypass Using Liraglutide or Surgical Revision. A Prospective Study
Authors: Horber Fritz F. , Steffen Rudolf
Published: July 2020

Purpose

This study investigates whether pharmacotherapy with liraglutide is similarly effective in reversing weight regain more than 6 years after Roux-en-Y gastric bypass (RYGB) as revisional surgery aimed at restoring restriction.

Methods

Ninety-five consecutive patients (11 male, 84 female; mean BMI 45 ± 6 kg/m2) undergoing RYGB 9 ± 4 years ago were treated for 24 months as follows: Patients, who gained less than 10% from weight NADIR, served as controls and were provided lifestyle counseling (DC, n = 30). The others were allowed to choose between three different treatment groups: daily s.c. administration of liraglutide (LG, n = 34); endosurgery using Apollo’s Overstitch System™ (ES, n = 15), or implantation of a Fobi-ring with pouch resizing (FP, n = 16).

Results

Controls kept their weight stable during 24 months of study (− 0.1 ± 1.7 kg/m2). Weight loss was 4.8 ± 2.9 kg/m2 for LG and 5.5 ± 2.9 kg/m2 for FP, both losing more than 85% of regained weight from weight NADIR (p < 0.001). In contrast, weight loss in ES was 1.0 ± 0.9 kg/m2 (i.e., 20% of regained weight). Thirty-seven percent of FP experienced serious complications (p < 0.05) in contrast to the other groups. An improved prevalence of hypertension and dyslipidemia was observed in LG and FP (p < 0.02) 24 months after intervention.

Conclusions

Weight regain during more than 6 years after RYGB can be safely and effectively reversed with liraglutide. Compared with revisional surgery, pharmacotherapy with liraglutide was low risk and resulted in an important improvement in hypertension and dyslipidemia. Therefore, daily subcutaneous injections of liraglutide are a valid option to treat weight regain after RYGB.
Efficiently and Effectively Recognizing Toricity of Steady State Varieties
Authors: Grigoriev Dima , Iosif Alexandru , Rahkooy Hamid , Sturm Thomas , Weber Andreas
Published: July 2020

We consider the problem of testing whether the points in a complex or real variety with non-zero coordinates form a multiplicative group or, more generally, a coset of a multiplicative group. For the coset case, we study the notion of shifted toric varieties which generalizes the notion of toric varieties. This requires a geometric view on the varieties rather than an algebraic view on the ideals. We present algorithms and computations on 129 models from the BioModels repository testing for group and coset structures over both the complex numbers and the real numbers. Our methods over the complex numbers are based on Gröbner basis techniques and binomiality tests. Over the real numbers we use first-order characterizations and employ real quantifier elimination. In combination with suitable prime decompositions and restrictions to subspaces it turns out that almost all models show coset structure. Beyond our practical computations, we give upper bounds on the asymptotic worst-case complexity of the corresponding problems by proposing single exponential algorithms that test complex or real varieties for toricity or shifted toricity. In the positive case, these algorithms produce generating binomials. In addition, we propose an asymptotically fast algorithm for testing membership in a binomial variety over the algebraic closure of the rational numbers.
Oligodendrocyte Response to Pathophysiological Conditions Triggered by Episode of Perinatal Hypoxia-Ischemia: Role of IGF-1 Secretion by Glial Cells
Authors: Janowska Justyna , Gargas Justyna , Ziemka-Nalecz Malgorzata , Zalewska Teresa , Sypecka Joanna
Published: July 2020

Differentiation of oligodendrocyte progenitors towards myelinating cells is influenced by a plethora of exogenous instructive signals. Insulin-like growth factor 1 (IGF-1) is one of the major factors regulating cell survival, proliferation, and maturation. Recently, there is an ever growing recognition concerning the role of autocrine/paracrine IGF-1 signaling in brain development and metabolism. Since oligodendrocyte functioning is altered after the neonatal hypoxic-ischemic (HI) insult, a question arises if the injury exerts any influence on the IGF-1 secreted by neural cells and how possibly the change in IGF-1 concentration affects oligodendrocyte growth. To quantify the secretory activity of neonatal glial cells, the step-wise approach by sequentially using the in vivo, ex vivo, and in vitro models of perinatal asphyxia was applied. A comparison of the results of in vivo and ex vivo studies allowed evaluating the role of autocrine/paracrine IGF-1 signaling. Accordingly, astroglia were indicated to be the main local source of IGF-1 in the developing brain, and the factor secretion was shown to be significantly upregulated during the first 24 h after the hypoxic-ischemic insult. And conversely, the IGF-1 amounts released by oligodendrocytes and microglia significantly decreased. A morphometric examination of oligodendrocyte differentiation by means of the Sholl analysis showed that the treatment with low IGF-1 doses markedly improved the branching of oligodendroglial cell processes and, in this way, promoted their differentiation. The changes in the IGF-1 amounts in the nervous tissue after HI might contribute to the resulting white matter disorders, observed in newborn children who experienced perinatal asphyxia. Pharmacological modulation of IGF-1 secretion by neural cells could be reasonable solution in studies aimed at searching for therapies alleviating the consequences of perinatal asphyxia.
1H, 13C and 15N resonance assignments for the microtubule-binding domain of the kinetoplastid kinetochore protein KKT4 from Trypanosoma brucei
Authors: Ludzia Patryk , Akiyoshi Bungo , Redfield Christina
Published: July 2020

KKT4 is a kinetoplastid-specific microtubule-binding kinetochore protein that lacks significant similarity to any known kinetochore or microtubule-binding proteins. Here we present the 1H, 13C and 15N resonance assignments for several fragments from the microtubule-binding domain of KKT4 (KKT4115–343) from Trypanosoma brucei. These assignments provide the starting point for detailed investigations of the structure, dynamics and interactions of the microtubule-binding region of KKT4.
Psychophysical comparison of the auditory and tactile perception: a survey
Authors: Merchel Sebastian , Altinsoy M. Ercan
Published: July 2020

In this paper, the psychophysical abilities and limitations of the auditory and vibrotactile modality will be discussed. A direct comparison reveals similarities and differences. The knowledge of those is the basis for the design of perceptually optimized auditory-tactile human–machine interfaces or multimodal music applications. Literature data and own results for psychophysical characteristics are summarized. An overview of the absolute perception thresholds of both modalities is given. The main factors which influence these thresholds are discussed: age, energy integration, masking and adaptation. Subsequently, the differential sensitivity (discrimination of intensity, frequency, temporal aspects and location) for suprathreshold signals is compared.
Growth, fatty, and amino acid profiles of the soil alga Vischeria sp. E71.10 (Eustigmatophyceae) under different cultivation conditions
Authors: Remias Daniel , Nicoletti Cecilia , Krennhuber Klaus , Möderndorfer Bettina , Nedbalová Linda , Procházková Lenka
Published: July 2020

In this study, a unicellular soil alga isolated from farmland in Germany was surveyed. The investigation of the hypervariable molecular markers ITS1 rDNA and ITS2 rDNA identified strain E71.10 as conspecific with Vischeria sp. SAG 51.91 (Eustigmatophyceae). The culture was tested for biomass generation and for the yield of fatty acids and amino acids. The survey included four different culture conditions (conventional, elevated CO2, nitrogen depletion, or sodium chloride stress) at room temperature. The best yield of dry biomass was achieved applying 1% CO2, whereas nitrogen-free medium resulted into least growth. The fatty acid content peaked in nitrogen-free medium at 59% per dry mass. Eicosapentaenoic acid was the most abundant fatty acid in all treatments (except for nitrogen free), accounting for 10.44 to 16.72 g/100 g dry mass. The highest content of amino acids (20%) was achieved under conventional conditions. The results show that abiotic factors strongly influence to which extent metabolites are intracellularly stored and they confirm also for this yet undescribed strain of Vischeria that Eustigmatophyceae are promising candidates for biotechnology.
Delineation of Average 1-D Shear Velocity Structure below North India by Surface Wave Dispersion Study
Authors: Gupta Abhishek Kumar , Mandal Prantik
Published: July 2020

During 2014-16, a semi-permanent network of four 3-component broadband seismographs was operational in the Rajasthan craton and Aravalli mobile belt in the NW Indian shield. The reliable and accurate broadband data from 16 selected regional Indian earthquakes of Mw5.5-7.8 from this seismic network enabled to estimate the group velocity dispersion characteristics and one-dimensional regional shear velocity structure of northern India, covering the region below north India between the entire Himalaya (from the Pakistan Himalaya in west to the Burmese arc in the east) and Rajasthan (including Aravalli mobile belt). First, Rayleigh- (at 7-87s) and Love- (at 7-82s) wave group velocity dispersion curves were measured and then these curves were inverted to estimate the crustal and upper mantle structure below north India. It is observed that group velocities are of variable nature within the region. This could be attributed to the complex crust-mantle structure in the study region resulted from the magmatism episodes associated with the Proterozoic collision, 65 Ma Deccan volcanism and the Himalayan collision. The best model in the study region reveals a two-layered crust, with a 15-km thick upper-crust (UC) of average shear velocity (Vs) of 3.12 km/s and a 25-km thick lower-crust(LC) of average Vs of 3.44 km/sec. The modeling detects a drop in Vs (~1-2%) at 79-120 km depths, underlying north India, representing the probable seismic lithosphere-asthenosphere boundary (LAB) at 79 km depth. A geothermal gradient extrapolated from the surface heat flow (~74 mW/m2) shows that such a gradient would intercept CO2-bearing mantle peridotite solidus at 100 km depth, and thus could signal the presence of small amounts of partially melted magma below 100 km depth. Therefore, this 1-2% drop in Vs could be attributed to the presence of carbonatite melts in the upper mantle related to magmatic episode of 65 Ma Deccan plume activity as also suggested by existing geological and seismological evidence.
Who Takes Part in the Political Game? The Sex Work Governance Debate in Israel
Authors: Levy-Aronovic Stephanie , Lahav-Raz Yeela , Raz Aviad
Published: July 2020

Introduction

This study explores the recent neo-abolitionist legislation of the Israeli sex industry by illustrating the competing claims of various stakeholders: those leading the legal change and those protesting it. The main question is how Israeli sex workers perceive the public debate over governing the Israeli sex industry.

Methods

This study combines qualitative methods that include ethnographic observations and interviews. The ethnographic observations were carried out between November 2018 and October 2019 in gatherings, protests, and academic conferences where sex workers were the lead speakers. In addition, 16 in-depth semi-structured interviews were conducted with sex workers across various indoor sectors, and four interviews were conducted with political figures to learn about their efforts to adopt neo-abolitionist legislation.

Results

the Israeli legislative proceedings initiated in 2007 deny sex workers a voice and exclude them from the political space and policy debates that have a direct bearing on their working lives and wellbeing. Thus, Israeli sex workers perceive sex work governance as controlling their agency and deepening their stigmatization. In this process, we show how contrasting groups became strange bedfellows in their attempt to protect sex workers by incriminating clients of the sex industry.

Conclusions

We conclude that the binary framings of debates about sex work in Israel do not address the actual needs or political desires of sex workers who are ignored and excluded from the discourse about them.

Policy Implications

Furthermore, we conclude that the issue at hand is not about permitting sex workers to express their views but rather about the need to listen to their critiques to ensure that policy is built on their knowledge and experience.
Semen Biochemical Components in Varicocele, Leukocytospermia, and Idiopathic Infertility
Authors: Collodel Giulia , Signorini Cinzia , Nerucci Fabiola , Gambera Laura , Iacoponi Francesca , Moretti Elena
Published: July 2020

The evaluation of the seminal plasma plays a relevant role in the definition of male infertility and in assisted reproduction outcomes; for this reason, it would be recommended to find biochemical markers able to characterize sperm pathology. In this study, 53 infertile patients (grouped by the presence leukocytospermia, idiopathic infertility, or varicocele) and 10 fertile men were selected. Spermiogram was performed by light microscopy, and sperm ultrastructure was evaluated by transmission electron microscopy (TEM) mathematically elaborated. Testosterone (TESTO), estradiol (E2), ferritin (FERR), iron (Fe), transferrin (TRSF), triglycerides (TRG), cholesterol (CHOL), and isoprostanes (F2-IsoPs) were detected in seminal plasma. Sperm characteristics and biochemical components were correlated by Spearman’s rank correlation coefficient in the whole population and in each group. The levels of TESTO and E2 were positively correlated with sperm quality in particular, and E2 was correlated with fertility index expressing the number of sperm free of ultrastructural defects evaluated by TEM. On the contrary, the indices of iron metabolism (FERR, Fe, and TRSF) were positively associated with low sperm quality and sperm necrosis, particularly in leukocytospermia and varicocele groups, pathologies in which an inflammatory status and oxidative stress condition are present. The study of the seminal plasma composition deserves attention because the levels of the various components seem to be associated with specific reproductive pathologies.
Male Sexual Function After Pediatric Kidney Transplantation—A Cross-sectional Nationwide Study
Authors: Tainio Juuso , Jahnukainen Timo , Jalanko Hannu , Jahnukainen Kirsi
Published: July 2020

Background

Data on adult sexual functioning after kidney transplantation (KTx) during childhood or adolescence are scarce.

Aim

To assess the long-term sexual and psychosocial quality of life after pediatric KTx.

Methods

29 young men (median age 27.1 years) were examined 18.7 years (median) after KTx. 56 age-matched healthy men (median age 30.0 years) served as controls.

Outcome

We studied the influence of sociodemographics, previous renal replacement therapy, current reproductive hormonal serum levels, testicular size, and data on several validated mental and physical questionnaires on participants' Derogatis Interview for Sexual Functioning self-report scores.

Results

The KTx recipients had significantly poorer sexual functioning than their healthy peers. KTx men had less frequent sexual activity with a partner (P = .03) and poorer orgasms (P = .002) than the controls but no erectile dysfunction (P = .5).

Clinical implications

Depressive symptoms, relationship status, and longer dialysis duration predicted poor adult sexual functioning in KTx recipients, whereas age at transplantation or at the time of the study did not.

Strengths & Limitations

This study contributes extended follow-up data to the very scarce literature on adult sexual functioning in pediatric KTx recipients. Relatively small population and low participation rate limit the comprehensive data interpretation in a population-based cohort of male KTx recipients.

Conclusion

Sexual functioning is often impaired in young men after pediatric KTx, emphasizing the need for long-term monitoring of sexual health and sexuality as important dimensions of quality of life.
The Bahá'í Faith, Violence, and Non-Violence
Authors: Stockman Robert H.
Published: July 2020

Both violence and non-violence are important themes in the Bahá'í Faith, but their relationship is not simple. The Bahá'í sacred writings see violence in the world – not just against Bahá'ís, but physical and structural violence against everyone – as being a consequence of the immature state of human civilization. The Baha'i community itself has been nonviolent since its founding by Baha'u'llah in the mid nineteenth century and has developed various strategies for responding to persecution nonviolently. This Element explores how their scriptures provide a blueprint for building a new, more mature, culture and civilization on this planet where violence will be rare and nonviolence prevalent.
Numerical modelling of thin anisotropic membrane under dynamic load
Authors: Aksenov V.V. , Vasyukov A.V. , Petrov I.B.
Published: July 2020

This work aims to describe a mathematical model and a numerical method to simulate a thin anisotropic membrane moving and deforming in 3D space under a dynamic load of an arbitrary time and space profile. The anisotropic continuum medium model described in the article can be used to model a membrane made of composite material using its effective elastic parameters. The model and the method allow the consideration of problems when the quasi-static approximation is not valid and elastic waves caused by the impact should be calculated. The model and the method can be used for numerical study of different processes in thin composite layers, such as shock load, ultrasound propagation, non-destructive testing procedures and vibrations. The thin membrane is considered as a 2D object in 3D space, an approach that allows a reduction in the computational time compared with full 3D models, while still having an arbitrary material rheology and load profile.
N-BERKELEY CARDINALS AND WEAK EXTENDER MODELS
Authors: CUTOLO RAFFAELLA
Published: July 2020

For a given inner model N of ZFC, one can consider the relativized version of Berkeley cardinals in the context of ZFC, and ask if there can exist an “N-Berkeley cardinal.” In this article we provide a positive answer to this question. Indeed, under the assumption of a supercompact cardinal
$\delta $
, we show that there exists a ZFC inner model N such that there is a cardinal which is N-Berkeley, even in a strong sense. Further, the involved model N is a weak extender model of
$\delta $
is supercompact. Finally, we prove that the strong version of N-Berkeley cardinals turns out to be inconsistent whenever N satisfies closure under
$\omega $
-sequences.
On decay rates of the solutions of parabolic Cauchy problems
Authors: Bonet José , Lusky Wolfgang , Taskinen Jari
Published: July 2020

We consider the Cauchy problem for a general class of parabolic partial differential equations in the Euclidean space ℝN. We show that given a weighted Lp-space $L_w^p({\mathbb {R}}^N)$ with 1 ⩽ p < ∞ and a fast growing weight w, there is a Schauder basis $(e_n)_{n=1}^\infty$ in $L_w^p({\mathbb {R}}^N)$ with the following property: given an arbitrary positive integer m there exists nm > 0 such that, if the initial data f belongs to the closed linear span of en with n ⩾ nm, then the decay rate of the solution of the problem is at least t−m for large times t.

The result generalizes the recent study of the authors concerning the classical linear heat equation. We present variants of the result having different methods of proofs and also consider finite polynomial decay rates instead of unlimited m.
The South, the West, and the meanings of humanitarian intervention in history
Authors: Quinton-Brown Patrick
Published: July 2020

As it has been written, the history of humanitarian intervention is all too Whiggish and all too white. By conceptualising humanitarian intervention in the way that they do, orthodox histories should be seen as entangled in debates about the origins of human rights but also, perhaps more crucially, debates about the various formations and reinventions of human rights. Alternative codifications of rights reveal the historical possibility of a Southern practice of what we would almost certainly call ‘humanitarian intervention’. The record of a radical Third World practice to save strangers from the atrocities of colonialism and extreme racism is also a record of Western states playing staunchly sovereigntist roles, of the West's late devotion to Westphalia. To sketch out such a counterhistory is to argue the following: at a threshold moment in the international-political life of the Responsibility to Protect, it is the terms, range, and domain of the intervention debate that must be re-formulated and re-evaluated.
A Human Arm’s Mechanical Impedance Tuning Method for Improving the Stability of Haptic Rendering
Authors: Lu Xiong , Qi Beibei , Zhao Hao , Sun Junbin
Published: July 2020

Rendering of rigid objects with high stiffness while guaranteeing system stability remains a major and challenging issue in haptics. Being a part of the haptic system, the behavior of human operators, represented as the mechanical impedance of arm, has an inevitable influence on system performance. This paper first verified that the human arm impedance can unconsciously be modified through imposing background forces and resist unstable motions arising from external disturbance forces. Then, a reliable impedance tuning (IT) method for improving the stability and performance of haptic systems is proposed, which tunes human arm impedance by superimposing a position-based background force over the traditional haptic workspace. Moreover, an adaptive IT algorithm, adjusting the maximum background force based on the velocity of the human arm, is proposed to achieve a reasonable trade-off between system stability and transparency. Based on a three-degrees-of-freedom haptic device, maximum achievable stiffness and transparency grading experiments are carried out with 12 subjects, which verify the efficacy and advantage of the proposed method.
Children's interpretation of negation and quantifier scope in L3 English
Authors: Jo Kyuhee , Kim Kitaek , Kim Hyunwoo
Published: July 2020

Languages differ in the preferences for the interpretation of the scope relation between negation and a quantifier. This study investigates the understudied issue of how interpretive preferences associated with a quantifier scope in learners’ L1 and L2 affect their scope interpretations in L3 acquisition. Based on the current models of L3 acquisition, we tested which language, L1 or L2, exerts a stronger effect on the L3 acquisition of quantifier scope. To this end, the study involved two groups of multilingual children (11–13 years old) with different L1s (Chinese or Russian) but with the same L2 (Korean) and L3 (English). The participants completed truth-value judgment tasks designed to investigate their interpretation patterns for English sentences with negation and a quantifier (e.g., Tom did not cut all the trees). The results showed that both groups preferred the L3 interpretation similar to that preferred in their L2, but not in their L1, suggesting a potential L2 influence on L3 acquisition. The study evaluates L3 acquisition theories in light of these results.
Adaptation, validation and reproducibility of a short FFQ to assess food group intake in the population resident in the Basque country (Spain)
Authors: Telleria-Aramburu N , Alegria-Lertxundi I , Arroyo-Izaga M
Published: July 2020

Objective:

To adapt a short FFQ (SFFQ) and evaluate its relative validity and reproducibility to assess food group intake in a population resident in the Basque Country. Moreover, the possible influence of associated variables (such as education level) on its validity and reproducibility was determined.

Design:

Nine-day 24-h recalls (24HR) were used as a reference to explore validity over the course of 1 year. The degree of misclassification in the SFFQ was evaluated by a contingency table of quartiles and by Bland–Altman plots comparing SFFQ2 and 24HR. SFFQ was administered twice to explore reproducibility at 1 year.

Setting:

Basque Autonomous Community.

Participants:

Adults aged ≥21 years (n 99). The sample was randomly selected and representative of the target population.

Results:

For validity, statistically significant correlations were observed for more than half of the food groups, with the lowest correlations (r or ρ) for fat (–0·008) and the highest for other foods (0·963). The mean percentage of the subjects’ food intake that was classified into the same or adjacent quartile in both methods was 75·2 %. Reproducibility was explored by the correlation coefficient and ranged from 0·201 to 0·809, and 82·6 % of participants were in the same or adjacent quartile in both SFFQ. The associated variables did not seem to influence the validity and reproducibility of the SFFQ.

Conclusions:

An adapted SFFQ presented good reproducibility and validity for measuring most food groups in the target population, and these results did not seem to be influenced by the associated variables.
A Dangerous Idea: Nonviolence as Tactic and Philosophy
Authors: Slate Nico
Published: July 2020

While some American civil rights activists professed belief in the “philosophy of nonviolence,” others declared nonviolent civil disobedience to be “a tactic rather than a philosophy.” Like many dichotomies, the tactic-versus-philosophy distinction combined as much as it divided. Those who viewed nonviolence as a tactic or method were treated as akin regardless of how much they differed in their tactics or methods. Similarly, those who believed in the philosophy of nonviolence were lumped together with each other and with those who saw nonviolence as a “way of life.” The history of the tactic-versus-philosophy dichotomy provides a unique window on the role of nonviolence within the American civil rights movement.
A NEW ARGUMENT FOR KOLOMOGOROV CONDITIONALIZATION
Authors: NIELSEN MICHAEL
Published: July 2020

This paper contributes to a recent research program that extends arguments supporting elementary conditionalization to arguments supporting conditionalization with general, measure-theoretic conditional probabilities. I begin by suggesting an amendment to the framework that Rescorla (2018) has used to characterize regular conditional probabilities in terms of avoiding Dutch book. If we wish to model learning scenarios in which an agent gains complete membership knowledge about some subcollection of the events of interest to her, then we should focus on updating policies that are what I shall callproper. I go on to characterize regular conditional probabilities in proper learning scenarios using what van Fraassen (1999) calls The General Reflection Principle.
TRANSMISSION OF VERIFICATION
Authors: BRAUER ETHAN , TENNANT NEIL
Published: July 2020

This paper clarifies, revises, and extends the account of the transmission of truthmakers by core proofs that was set out in chap. 9 of Tennant (2017). Brauer provided two kinds of example making clear the need for this. Unlike Brouwer’s counterexamples to excluded middle, the examples of Brauer that we are dealing with here establish the need for appeals to excluded middle when applying, to the problem of truthmaker-transmission, the already classical metalinguistic theory of model-relative evaluations.
THE MODAL LOGIC OF STEPWISE REMOVAL
Authors: VAN BENTHEM JOHAN , MIERZEWSKI KRZYSZTOF , ZAFFORA BLANDO FRANCESCA
Published: July 2020

We investigate the modal logic of stepwise removal of objects, both for its intrinsic interest as a logic of quantification without replacement, and as a pilot study to better understand the complexity jumps between dynamic epistemic logics of model transformations and logics of freely chosen graph changes that get registered in a growing memory. After introducing this logic (MLSR) and its corresponding removal modality, we analyze its expressive power and prove a bisimulation characterization theorem. We then provide a complete Hilbert-style axiomatization for the logic of stepwise removal in a hybrid language enriched with nominals and public announcement operators. Next, we show that model-checking for MLSR is PSPACE-complete, while its satisfiability problem is undecidable. Lastly, we consider an issue of fine-structure: the expressive power gained by adding the stepwise removal modality to fragments of first-order logic.
The Moderating Role of Work-Related Rumination in Nurses’ Sleep Quality Trajectory During Morning Shift Work
Authors: Haun Verena C. , Baethge Anja
Published: July 2020

Abstract. This diary study investigated nurses’ recovery after transitioning to morning shift work (i.e., their short-term adaptation to shift work) by examining the change trajectory of sleep quality over the course of five consecutive morning shifts. Results of latent growth analyses ( N = 132) showed that nurses’ sleep quality started at low levels and increased rapidly in the beginning until it stabilized toward the end of the shift work period. Moreover, work-related rumination moderated the sleep quality trajectory. When rumination was low, nurses’ sleep quality showed a quadratic trajectory, whereas when rumination was high, sleep quality showed a flatter and linear trajectory, suggesting that rumination impedes recovery after the transition and adaptation to morning shift work.
Thermal Fatigue as a Driving Mechanism for Activity on Asteroid Bennu
Authors: Molaro J. L. , Hergenrother C. W. , Chesley S. R. , Walsh K. J. , Hanna R. D. , Haberle C. W. , Schwartz S. R. , Ballouz R.‐L. , Bottke W. F. , Campins H. J. , Lauretta D. S.
Published: July 2020

Many boulders on (101955) Bennu, a near‐Earth rubble pile asteroid, show signs of in situ disaggregation and exfoliation, indicating that thermal fatigue plays an important role in its landscape evolution. Observations of particle ejections from its surface also show it to be an active asteroid, though the driving mechanism of these events is yet to be determined. Exfoliation has been shown to mobilize disaggregated particles in terrestrial environments, suggesting that it may be capable of ejecting material from Bennu's surface. We investigate the nature of thermal fatigue on the asteroid, and the efficacy of fatigue‐driven exfoliation as a mechanism for generating asteroid activity, by performing finite element modeling of stress fields induced in boulders from diurnal cycling. We develop a model to predict the spacing of exfoliation fractures and the number and speed of particles that may be ejected during exfoliation events. We find that crack spacing ranges from ~1 mm to 10 cm and disaggregated particles have ejection speeds up to ~2 m/s. Exfoliation events are most likely to occur in the late afternoon. These predictions are consistent with observed ejection events at Bennu and indicate that thermal fatigue is a viable mechanism for driving asteroid activity. Crack propagation rates and ejection speeds are greatest at perihelion when the diurnal temperature variation is largest, suggesting that events should be more energetic and more frequent when closer to the Sun. Annual thermal stresses that arise in large boulders may influence the spacing of exfoliation cracks or frequency of ejection events.
Modeling Process‐Based Biogeochemical Dynamics in Surface Fresh Waters of Large Watersheds With the IMAGE‐DGNM Framework
Authors: Vilmin L. , Mogollón J. M. , Beusen A. H. W. , van Hoek W. J. , Liu X. , Middelburg J. J. , Bouwman A. F.
Published: July 2020

Over the last centuries, human activities have exerted increasing pressures on the environment, leading to drastic alterations in the functioning of freshwater bodies (e.g., eutrophication). Global biogeochemical models have proven crucial to investigate interactions between humans, hydrology, and water quality of surface fresh waters. However, most do not account for high‐resolution spatial and temporal variability within watersheds, and they typically lack any representation of benthic dynamics that can drive pollution legacy effects. We present here the Integrated Model to Assess the Global Environment‐Dynamic Global Nutrient Model (IMAGE‐DGNM), which couples global, spatially explicit hydrology and integrated assessment models with process‐based biogeochemistry in surface fresh waters. The new Dynamic In‐Stream Chemistry (DISC) module calculates advective transport from headwaters to estuaries, processes in the water column and in bed sediments, as well as the exchanges between these two compartments. As application examples of IMAGE‐DGNM, we simulate sediment dynamics and nitrogen cycling in two large river basins. We assess in‐stream concentration time series at specific locations, and identify governing processes in transfers along the aquatic continuum. Results highlight the importance of benthic dynamics in watersheds highly perturbed by damming. The implementation of such dynamics within IMAGE‐DGNM allows for including the temporal effect of pollution legacies in large scale water quality studies and shifts in pollutant speciation along river continua. This new framework therefore incorporates new features for large basin to global scale studies that are crucial to better predict the effects on receiving ecosystems and evaluate future environmental management pathways.
South-to-North Water Diversion stabilizing Beijing’s groundwater levels
Authors: Long Di , Yang Wenting , Scanlon Bridget R. , Zhao Jianshi , Liu Dagen , Burek Peter , Pan Yun , You Liangzhi , Wada Yoshihide
Published: July 2020

Groundwater (GW) overexploitation is a critical issue in North China with large GW level declines resulting in urban water scarcity, unsustainable agricultural production, and adverse ecological impacts. One approach to addressing GW depletion was to transport water from the humid south. However, impacts of water diversion on GW remained largely unknown. Here, we show impacts of the central South-to-North Water Diversion on GW storage recovery in Beijing within the context of climate variability and other policies. Water diverted to Beijing reduces cumulative GW depletion by ~3.6 km3, accounting for 40% of total GW storage recovery during 2006–2018. Increased precipitation contributes similar volumes to GW storage recovery of ~2.7 km3 (30%) along with policies on reduced irrigation (~2.8 km3, 30%). This recovery is projected to continue in the coming decade. Engineering approaches, such as water diversions, will increasingly be required to move towards sustainable water management.
Rhodanine-based Knoevenagel reaction and ring-opening polymerization for efficiently constructing multicyclic polymers
Authors: Zhang Ze , Nie Xuan , Wang Fei , Chen Guang , Huang Wei-Qiang , Xia Lei , Zhang Wen-Jian , Hao Zong-Yao , Hong Chun-Yan , Wang Long-Hai , You Ye-Zi
Published: July 2020

Cyclic polymers have a number of unique physical properties compared with those of their linear counterparts. However, the methods for the synthesis of cyclic polymers are very limited, and some multicyclic polymers are still not accessible now. Here, we found that the five˗membered cyclic structure and electron withdrawing groups make methylene in rhodanine highly active to aldehyde via highly efficient Knoevenagel reaction. Also, rhodanine can act as an initiator for anionic ring-opening polymerization of thiirane to produce cyclic polythioethers. Therefore, rhodanine can serve as both an initiator for ring-opening polymerization and a monomer in Knoevenagel polymerization. Via rhodanine-based Knoevenagel reaction, we can easily incorporate rhodanine moieties in the backbone, side chain, branched chain, etc, and correspondingly could produce cyclic structures in the backbone, side chain, branched chain, etc, via rhodanine˗based anionic ring-opening polymerization. This rhodanine chemistry would provide easy access to a wide variety of complex multicyclic polymers.
Author Correction: The LipoGlo reporter system for sensitive and specific monitoring of atherogenic lipoproteins
Authors: Thierer James H. , Ekker Stephen C. , Farber Steven A.
Published: July 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Publisher Correction: Seismic ground vibrations give advanced early-warning of subglacial floods
Authors: Eibl Eva P. S. , Bean Christopher J. , Einarsson Bergur , Pàlsson Finnur , Vogfjörd Kristin S.
Published: July 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Delayed cytokinesis generates multinuclearity and potential advantages in the amoeba Acanthamoeba castellanii Neff strain
Authors: Quinet Théo , Samba-Louaka Ascel , Héchard Yann , Van Doninck Karine , Van der Henst Charles
Published: July 2020

Multinuclearity is a widespread phenomenon across the living world, yet how it is achieved, and the potential related advantages, are not systematically understood. In this study, we investigate multinuclearity in amoebae. We observe that non-adherent amoebae are giant multinucleate cells compared to adherent ones. The cells solve their multinuclearity by a stretchy cytokinesis process with cytosolic bridge formation when adherence resumes. After initial adhesion to a new substrate, the progeny of the multinucleate cells is more numerous than the sibling cells generated from uninucleate amoebae. Hence, multinucleate amoebae show an advantage for population growth when the number of cells is quantified over time. Multiple nuclei per cell are observed in different amoeba species, and the lack of adhesion induces multinuclearity in diverse protists such as Acanthamoebacastellanii, Vermamoebavermiformis, Naegleriagruberi and Hartmannellarhysodes. In this study, we observe that agitation induces a cytokinesis delay, which promotes multinuclearity. Hence, we propose the hypothesis that multinuclearity represents a physiological adaptation under non-adherent conditions that can lead to biologically relevant advantages.
Fermented soybean meal affects the ruminal fermentation and the abundance of selected bacterial species in Holstein calves: a multilevel analysis
Authors: Feizi Leila Kaviani , Zad Sabihe Soleymanian , Jalali Seyed Amir Hossein , Rafiee Hassan , Jazi Masoud Boroumand , Sadeghi Khaled , Kowsar Rasoul
Published: July 2020

The effect of soybean meal (SBM) replacement with fermented SBM (FSBM) on ruminal fermentation and bacterial abundance in Holstein calves was investigated in this study. Thirty nine calves were randomized to: (1) control: 27% SBM + 0% FSBM (FSBM0, n = 13); (2) 18% SBM + 9% FSBM (FSBM9, n = 13); and (3) 13.5% SBM + 13.5% FSBM (FSBM13, n = 13). SBM contained a greater amount of large peptides containing 3 to 10 amino acids (AAs), while FSBM had a greater amount of ammonia nitrogen (NH3–N), free AAs, and small peptides containing 2 to 3 AAs. The calves fed FSBM13 had the lowest acetic acid, NH3–N, and the ratio of acetate to propionate, with the greatest concentration of caproic acid, valeric acid and isovaleric acid in ruminal fluid. Compared to those fed FSBM9 or FSBM13, the calves fed FSBM0 had the greatest proportion of Butyrivibrio fibrisolvens and Ruminococcus albus in rumen fluid. However, the ruminal abundance of Prevotella ruminicola in calves fed FSBM13 was greater than in calves fed FSBM0. Network analysis showed that the abundance of the Ruminococcus albus was associated with large peptides, and butyric acid was correlated with small peptide. Taken together, our findings suggest that FSBM may have the potential to boost calf performance by changing the fermentation products and the relative abundance of some members of the bacterial community in the rumen.
Circulatory and prostatic tissue lipidomic profiles shifts after high-dose atorvastatin use in men with prostate cancer
Authors: Raittinen Paavo , Niemistö Kati , Pennanen Erika , Syvälä Heimo , Auriola Seppo , Riikonen Jarno , Lehtimäki Terho , Ilmonen Pauliina , Murtola Teemu
Published: July 2020

Prostate cancer patients using cholesterol-lowering statins have 30% lower risk of prostate cancer death compared to non-users. The effect is attributed to the inhibition of the mevalonate pathway in prostate cancer cells. Moreover, statin use causes lipoprotein metabolism changes in the serum. Statin effect on serum or intraprostatic lipidome profiles in prostate cancer patients has not been explored. We studied changes in the serum metabolomic and prostatic tissue lipidome after high-dose 80 mg atorvastatin intervention to expose biological mechanisms causing the observed survival benefit. Our randomized, double-blind, placebo-controlled clinical trial consisted of 103 Finnish men with prostate cancer. We observed clear difference in post-intervention serum lipoprotein lipid profiles between the study arms (median classification error 11.7%). The atorvastatin effect on intraprostatic lipid profile was not as clear (median classification error 44.7%), although slightly differing lipid profiles by treatment arm was observed, which became more pronounced in men who used atorvastatin above the median of 27 days (statin group median classification error 27.2%). Atorvastatin lowers lipids important for adaptation for hypoxic microenvironment in the prostate suggesting that prostate cancer cell survival benefit associated with statin use might be mediated by both, local and systemic, lipidomic/metabolomic profile changes.
Source rock evaluation of Afowo clay type from the Eastern Dahomey Basin, Nigeria: insights from different measurements
Authors: Mohammed Saeed , Opuwari Mimonitu , Titinchi Salam
Published: July 2020

The Cretaceous Afowo Formation in the Eastern Dohamey Basin is characterized by an admixture of lithofacies ranging from sandstones, claystones, shales, clays, sand/shale, and sand/clay intercalations. The sandy facies, a mix of sandstone, clay, shale, and intercalations, contain biodegraded hydrocarbons while the shales and claystones that underlie it are rich in organic matter. The hydrocarbon-bearing interval is commonly referred to as the oil sand or tar sand. In this study, Afowo clay type underlying an outcrop of the oil sand was appraised for its hydrocarbon potential with loss on ignition, thermogravimetry, and rock evaluation pyrolysis. Results obtained from loss on ignition showed that total organic matter content, a proxy to total organic carbon, for the Afowo clay type ranged from 9.410 to 38.750 wt%. The organic maturation temperature (Tmax) was determined using both thermogravimetry and rock evaluation pyrolysis (Rock–Eval). Thermogravimetric analysis produced reliable Tmax within the range of 417–424 °C for all the samples. The results from rock evaluation pyrolysis on the same samples showed that total organic carbon ranged from 0.81 to 18.46 wt% with Tmax ranging from 417 to 424 °C. It was not possible to determine Tmax for one of the samples with Rock–Eval due to a small S2 value (0.22 mg Hc/g). The variations in organic matter contents from loss on ignition agree with total organic carbon computed from rock evaluation pyrolysis; samples with high organic matter contents have corresponding high TOC values. This study demonstrates that loss on ignition and thermogravimetry could complement and augment rock evaluation pyrolysis data for petroleum source rock characterization.
Experimental infection of hepatitis E virus induces pancreatic necroptosis in miniature pigs
Authors: Jung Soontag , Seo Dong Joo , Yeo Daseul , Wang Zhaoqi , Min Ae , Zhao Ziwei , Song Mengxiao , Choi In-Soo , Myoung Jinjong , Choi Changsun
Published: July 2020

Infection by hepatitis E virus (HEV) via the oral route causes acute hepatitis. Extra-hepatic manifestations of HEV infection may stem from various causes; however, its distribution in organs such as the liver, as well as the mechanisms underlying HEV-induced cell injury, remain unclear. The objective of this study was to determine the chronological distribution of HEV in various tissues of HEV-challenged miniature pigs and to investigate the mechanisms underlying HEV-induced cell death in the pancreas and liver. Virological and serological analyses were performed on blood and faecal samples. Histopathology of the liver and extra-hepatic tissues was analysed. Cell death pathways and immune cell characterisation in inflammatory lesions were analysed using immunohistochemistry. The liver and pancreas displayed inflammation and cellular injury, and a large amount of HEV was observed in the lesions. The liver was infiltrated by T and natural killer cells. HEV was identified in all organs except the heart, and was associated with immune cells. Although the liver and the pancreas strongly expressed TNF-α and TRAIL, TUNEL assay results were negative. RIP3 and pMLKL were expressed in the pancreas. RIP3, but not pMLKL, was expressed in the liver. Pancreatitis induced in HEV-infected miniature pigs is associated with necroptosis.
Severity and long-term complications of surgical site infections after orthognathic surgery: a retrospective study
Authors: Cousin Anne-Sabine , Bouletreau Pierre , Giai Joris , Ibrahim Badr , Louvrier Aurélien , Sigaux Nicolas
Published: July 2020

Surgical site infections (SSI) occur in 1.4% to 33.4% of cases after orthognathic surgery. This type of complication is a major concern to surgical teams, but there is no consensus for the prevention and treatment of SSI in orthognathic surgery. The purpose of this descriptive study was to evaluate the severity and the consequences of postoperative infections. The charts of all the patients operated on by the orthognathic surgery team between January 2015 and July 2017 were collected. All types of orthognathic procedures (Le Fort I maxillary osteotomy, bilateral sagittal split mandibular osteotomy, and genioplasty) were screened, and patients diagnosed with SSI were included. Demographic data, timing and severity of the infection, as well as long-term complications were recorded. Five hundred and twelve patients were screened. Forty-one patients (8%) presenting with SSI were included. There were 18 men and 23 women. The site of the infection was mandibular for 38 patients (92.7%) and maxillary for 3 patients (7.3%). The average time between surgery and infection was 31.5 days. Twenty-four patients received isolated oral antibiotics for inflammatory cellulitic reaction (58.8%), 15 patients had a localized collection treated by incision and drainage under local anesthesia (36.6%), and 2 patients had an extensive collection requiring surgical drainage under general anesthesia (4.9%). Five patients (12.2%) needed hardware removal for plate loosening, and 2 patients (4.9%) developed chronic osteomyelitis. Infection following orthognathic surgery is easily treated most of the time with no long-term complications. In cases of patients with potential risk factors for severe infection, antibiotics may be given with curative intents.