bluuebunny/crossref_metadata_2025 huggingface dataset:
Genotype and phenotype landscape of MEN2 in 554 medullary thyroid cancer patients: the BrasMEN study
Authors: Maciel Rui M B , Camacho Cleber P , Assumpção Lígia V M , Bufalo Natassia E , Carvalho André L , de Carvalho Gisah A , Castroneves Luciana A , de Castro Francisco M , Ceolin Lucieli , Cerutti Janete M , Corbo Rossana , Ferraz Tânia M B L , Ferreira Carla V , França M Inez C , Galvão Henrique C R , Germano-Neto Fausto , Graf Hans , Jorge Alexander A L , Kunii Ilda S , Lauria Márcio W , Leal Vera L G , Lindsey Susan C , Lourenço Delmar M , Maciel Léa M Z , Magalhães Patrícia K R , Martins João R M , Martins-Costa M Cecília , Mazeto Gláucia M F S , Impellizzeri Anelise I , Nogueira Célia R , Palmero Edenir I , Pessoa Cencita H C N , Prada Bibiana , Siqueira Débora R , Sousa Maria Sharmila A , Toledo Rodrigo A , Valente Flávia O F , Vaisman Fernanda , Ward Laura S , Weber Shana S , Weiss Rita V , Yang Ji H , Dias-da-Silva Magnus R , Hoff Ana O , Toledo Sergio P A , Maia Ana L
Published: February 2019

Multiple endocrine neoplasia type 2 (MEN2) is an autosomal dominant genetic disease caused by RET gene germline mutations that is characterized by medullary thyroid carcinoma (MTC) associated with other endocrine tumors. Several reports have demonstrated that the RET mutation profile may vary according to the geographical area. In this study, we collected clinical and molecular data from 554 patients with surgically confirmed MTC from 176 families with MEN2 in 18 different Brazilian centers to compare the type and prevalence of RET mutations with those from other countries. The most frequent mutations, classified by the number of families affected, occur in codon 634, exon 11 (76 families), followed by codon 918, exon 16 (34 families: 26 with M918T and 8 with M918V) and codon 804, exon 14 (22 families: 15 with V804M and 7 with V804L). When compared with other major published series from Europe, there are several similarities and some differences. While the mutations in codons C618, C620, C630, E768 and S891 present a similar prevalence, some mutations have a lower prevalence in Brazil, and others are found mainly in Brazil (G533C and M918V). These results reflect the singular proportion of European, Amerindian and African ancestries in the Brazilian mosaic genome.
Vaspin promotes insulin sensitivity in elderly muscle and is upregulated in obesity
Authors: Nicholson Thomas , Church Chris , Tsintzas Kostas , Jones Robert , Breen Leigh , Davis Edward T , Baker David J , Jones Simon W
Published: February 2019

Adipokines have emerged as central mediators of insulin sensitivity and metabolism, in part due to the known association of obesity with metabolic syndrome disorders such as type 2 diabetes. Recent studies in rodents have identified the novel adipokine vaspin as playing a protective role in inflammatory metabolic diseases by functioning as a promoter of insulin sensitivity during metabolic stress. However, at present the skeletal muscle and adipose tissue expression of vaspin in humans is poorly characterised. Furthermore, the functional role of vaspin in skeletal muscle insulin sensitivity has not been studied. Since skeletal muscle is the major tissue for insulin-stimulated glucose uptake, understanding the functional role of vaspin in human muscle insulin signalling is critical in determining its role in glucose homeostasis. The objective of this study was to profile the skeletal muscle and subcutaneous adipose tissue expression of vaspin in humans of varying adiposity, and to determine the functional role of vaspin in mediating insulin signalling and glucose uptake in human skeletal muscle. Our data shows that vaspin is secreted from both human subcutaneous adipose tissue and skeletal muscle, and is more highly expressed in obese older individuals compared to lean older individuals. Furthermore, we demonstrate that vaspin induces activation of the PI3K/AKT axis, independent of insulin receptor activation, promotesGLUT4expression and translocation and sensitises older obese human skeletal muscle to insulin-mediated glucose uptake.
Corrupción pública y suspensión de la ejecución de la pena
Authors: Cardenal Montraveta Sergi
Published: February 2019

Algunas decisiones judiciales recientes, que deniegan la suspensión de la ejecución de las penas de prisión impuesta por delitos relacionados con la corrupción pública, reflejan un cambio sobre el papel que el Derecho penal debe jugar para su prevención. Tras exponer las circunstancias esenciales de tales decisiones analizamos, desde una perspectiva general, la función del Derecho penal y su relación con la regulación de la suspensión de la ejecución de la pena, destacando que la suspensión sólo está justifica cuando es la opción que ofrece el mejor saldo preventivo global o la ejecución infringiría el principio de proporcionalidad. Finalmente se analizan diversos elementos frecuentes en la delincuencia relacionada con la corrupción pública, que son aquí relevantes y que a menudo justificarán la decisión de ejecutar las penas impuestas, también cuando concurran los requisitos previstos en el art. 80 CP para acordar la suspensión.
Factores de aumento de la población penitenciaria en el Perú, medidas alternativas y vigilancia electrónica.
Authors: Nunovero Lucia Betty
Published: February 2019

El presente artículo examina si la Vigilancia Electrónica de detenidos en el Perú podrá reducir la sobrepoblación penitenciaria que enfrenta el país entre otros retos de Política Criminal comunes a los países de América Latina. Estableciendo una clasificación funcional de las alternativas a la prisión, realizamos un análisis longitudinal y transversal de las estadísticas penitenciarias de los años 2012 a 2016 encontrando un flujo estable de ingresos a cárceles a pesar del mayor uso de alternativas a la prisión de modalidad sustitutiva y de una menor proporción de presos en situación de procesados. En efecto, el incremento anual de aproximadamente 6% de detenidos en el Perú, el más alto que muestra el país en las últimas décadas, aparece en el contexto de mayor aplicación de penas alternativas y de disminución de presos en detención preventiva por lo que no se encuentra evidencia de que la vigilancia electrónica puedan contribuir a reducir una población penitenciaria que incrementa su población de sentenciados y de detenidos por crímenes violentos y de drogas a quienes corresponden penas más severas y mayores tiempos de reclusión.
La polémica en el delito de financiación de partidos políticos: las puertas continúan abiertas
Authors: Rebollo Vargas Rafael
Published: February 2019

En el trabajo se analizan una serie de cuestiones estructurales del nuevo delito de financiación ilegal de partidos políticos, poniendo en evidencia no sólo la utilización de una técnica legislativa precipitada y defectuosa; sino, también, los vacíos punitivos que permiten a los partidos políticos continuar nutriéndose ilegítimamente de fondos, tanto públicos como privados, ya sea a través de sus propias fundaciones, de condonaciones de deuda, a través de donaciones de bienes inmuebles o mediante la financiación pública ilícita.
Modelos de protección penal de la propiedad pública
Authors: Abanto Vásquez Manuel
Published: February 2019

Se comparan los modelos de protección penal de la propiedad pública en el sistema alemán, y, respresentando a los países "románicos", el hispano y el peruano. El primero se caracteriza por utilizar los tipos penales previstos para los "delitos contra la propiedad", especialmente los de "estafa" y "administración desleal", mientras que el segundo modelo ubica la protección penal dentro de un grupo más amplio referido a los delitos contra la administración pública. El articulo analiza la forma cómo funcionan ambos modelos de protección penal cuando en los atentados contra la "propiedad pública" intervienen "funcionarios públicos", con especial referencia a la "contratación pública". Se busca identificar las ventajas y desventajas de ambos modelos para proponer mejoras en la protección penal.
Elementos subjetivos del delito y límites de las compliance penales: a propósito de la difícil delimitación entre gastos de representación y pagos de facilitación
Authors: Cugat Mauri Miriam
Published: February 2019

Para que una compliance sea eficaz debe definir pautas de actuación claras y precisas que se erijan en obstáculo cierto de la actuación delictiva. Frente a ese desiderátum, las compliance anticorrupción presentan algunas vías de agua. Por un lado, los contornos de las figuras delictivas de las que pueden responder las personas jurídicas y en especial el cohecho se desdibujan en sus niveles inferiores, en los que no siempre está clara la frontera entre los gastos de representación y los pagos de facilitación. Por otro lado, el componente subjetivo, esencial en estos delitos, difícilmente podrá ser aprehendido por normas de conducta estandarizadas. En este artículo se reflexiona acerca de la función y límites de las compliane en la prevención de los delitos de corrupción.
Associationalism and Panopticism in American Democracy: An Analysis of Jewish Power
Authors: Ramey Daniel
Published: February 2019

This paper combines the theories of Alexis de Tocqueville and Michel Foucault to explain the political power Jewish associations have accrued in the United States. By applying Tocqueville’s idea of associationalism and Foucault’s interpretation of panopticism together, it is possible to analyze how the majority and minority access and respond to power in American Democracy. Through associationalism, American Jews could make themselves visible without breaching any norms—and could become part of the structure of panoptic surveillance as well. Jewish experiences as a diaspora people prepared Jewish associations for the challenges of assimilation and political organizing. This research draws upon mostly Tocqueville and Foucault’s classic texts, articles on Jewish studies, and primary sources including memoirs.
Significant occurrence of Musellifer profundus Vivier, 1974 (Gastrotricha, Chaetonotida) in the Black Sea
Authors: Sergeeva Nelli , Ürkmez Derya , Todaro M. Antonio
Published: February 2019

Specimens of the gastrotrich genus Musellifer are recorded for the first time from the Black Sea. These specimens, identified as M. profundus Vivier, 1974, were found in sediment samples collected at various depths (22−135 m) and from waters characterized by low salinity (17.3−18.62‰) and varying levels of oxygen (2.43−299.59 μM). Three specimens were found from the Istanbul Strait (Bosphorus) outlet area of the Black Sea (Turkey) and 2 were found along the southern and southeastern shelf of the Crimean Peninsula (Russia), from the Yalta Gulf and the Feodosiya Gulf.
ISOLATION, CHARACTERIZATION, AND IDENTIFICATION OF PROTEOLYTIC BACTERIA TO IMPROVE PROTEIN DIGESTIBILITY OF FISH FEED INGREDIENTSISOLATION, CHARACTERIZATION, AND IDENTIFICATION OF PROTEOLYTIC BACTERIA TO IMPROVE PROTEIN DIGESTIBILITY OF FISH FEED INGREDIENTS
Authors: Mulyasari Muyasari , Sunarno Mas Tri Djoko , Suryaningrum Lusi Herawati
Published: February 2019

Protease is one of the potential enzymes used to improve the quality of local raw materials as fish feedstuff. The aim of this research was to find high protease activity-bacteria isolates in improving protein digestibility of fish feedstuff. Isolation was conducted on various growth substrates such as water and sediment of hot springs, mangrove sediment, and shrimp head waste. The parameters used in the selection and characterization of potential proteolytic bacteria were qualitative and quantitative tests of proteolytic activity. Microbes that have the highest enzyme activity were then selected and characterized based on their growth curve, production time of protease, and determination of optimum condition (temperature and pH) of protease activity. The result showed that there are only 18 isolates from 44 isolates positively had protease activity (qualitatively). Three isolates with the highest activity (RGL1.1, PL1.1, and PL1.2) qualitatively and quantitatively were then selected to be tested for their pathogenecity on tilapia. The results showed that only RGL1.1 was not pathogenic and therefore, potentially used as a protease producer candidate. The characterization of RGL1.1 isolates showed that the exponential phase of RGL1.1 was thirty-sixth hour in line with the optimum activity of enzyme production. The optimum pH and temperature of RGL1.1 isolate were 6 and 50°C, respectively. RGL1.1 isolate is a Gram-positive rod-shaped bacteria that has 99.53% of resemblance to Bacillus cereus.
TRANSMISI GEN krt-GP11 DAN PERFORMA KETAHANAN IKAN MAS (Cyprinus carpio) TRANSGENIK F-2 TERHADAP INFEKSI KHV
Authors: Syahputra Khairul , Palimirmo Flandrianto Sih , Himawan Yogi
Published: February 2019

Pembentukan ikan mas transgenik merupakan salah satu program penelitian di Balai Penelitian Pemuliaan Ikan, Sukamandi dalam rangka menghasilkan varietas unggul ikan mas tahan infeksi KHV (Koi herpesvirus). Pada tahun 2015 telah dilakukan pembentukan ikan mas transgenik tahan KHV generasi F-2. Penelitian ini bertujuan untuk mengevaluasi transmisi gen krt-GP11, ketahanan ikan mas transgenik F-2 terhadap infeksi KHV, keberadaan marka Cyca-DAB1*05 tahan KHV pada populasi ikan mas transgenik F-2. Ikan mas transgenik F-2 dihasilkan dengan memijahkan ikan mas transgenik F-1 jantan dengan betina non-transgenik. Pengujian transmisi transgen dan deteksi marka ketahanan KHV pada transgenik F-2 dilakukan dengan metode PCR menggunakan primer spesifik untuk transgen krt-GP11 dan gen Cyca-DAB1*05. Evaluasi ketahanan ikan mas transgenik F-2 terhadap infeksi KHV dilakukan dengan uji tantang secara kohabitasi. Hasil penelitian menunjukkan bahwa transmisi gen krt-GP11 pada keturunan F-2 memiliki persentase yang relatif rendah yaitu sebesar 0%-2%. Ikan mas transgenik F-2 memiliki ketahanan relatif baik terhadap KHV dengan sintasan uji tantang sebesar 90% dan tidak berbeda nyata dengan ikan mas pembanding atau non-transgenik (P>0,05). Tingginya pesentase keberadaan marka Cyca-DAB1*05 pada populasi transgenik berperan pada ketahanan ikan mas transgenik terhadap infeksi KHV.Creating of transgenic common carp is one of the breeding programs in Research Institute for Fish Breeding for producing a superior strain of common carp resistant to KHV(Koi herpesvirus). Since 2015, the creation of common carp transgenic has been conducted to produce F2 population resistant to KHV. This study was aimed to evaluate the transmission of krt-GP11 gen,the resistantce of F2 transgenic common carp against to KHV infection, and the existence of Cyca-DAB1*05 marker resistant to KHV in F2 transgenic population. F2 transgenic population has been produced by mating F1 transgenic male with non transgenic female. Transgene transmission and the existence of marker resistant to KHV in F2 transgenic population were evaluated by PCR method using specific primer to krt-GP11 gene and Cyca-DAB1*05 gene, respectively. The resistance of F2 transgenic population againstto KHV infection was evaluated by challenge test using cohabitation method. The result showed that transmission of krt-GP11 gene in F2transgenic population was relatively low with percentage of 0-2%. The resistance of F2 transgenic common carp against to KHV was relatively high with survival rate of 90% and was not significantly different from non transgenic (p>0.05). High percentage of transgenic population having Cyca-DAB1*05 marker had a role in resistance of transgenic population against KHV infection.
Proposta de redução do lead-time de uma linha de pintura automotiva
Authors: Silva Eduardo José , Pereira Carla Roberta , Bond Danielle
Published: February 2019

O processo de pintura é fundamental em qualquer indústria automotiva, porém é complexo e envolve etapas que exigem um controle químico e técnico, o que pode gerar desperdício e influenciar no lead time de entrega do produto final para a etapa seguinte. O presente artigo tem como enfoque apresentar uma proposta de redução do lead time em uma linha de pintura automotiva, de forma a adequar o sistema produtivo ao takt time por meio da redução de desperdícios durante o processo de produção. Como base para o estudo, foi realizada uma revisão de literatura a respeito do processo de pintura automotiva, a fim de entender o impacto das operações no lead-time total de produção, assim como do Sistema Toyota de Produção e o Mapeamento do Fluxo de Valor (MFV). O método adotado para a pesquisa foi o estudo de caso. O estudo foi realizado em uma empresa multinacional que atua no setor automotivo premium, na qual aplicaram-se as seguintes ferramentas: mapeamento do fluxo de valor (MFV), diagrama de espaguete, estudo de tempos e métodos e gráfico de balanceamento de operadores. Como resultado, obteve-se uma redução de 26% no lead time total da linha de pintura, bem como uma redução de 31% nos estoques entre processos (WIP) e um aumento de 5% na disponibilidade média da linha.
Aplicação da SMED para aumento de produtividade: estudo de caso na indústria de autopeças
Authors: Antonio Paulo Ricardo , Cagnin Fernanda , Helleno André Luís
Published: February 2019

A busca por melhores resultados da capacidade do processo de produção faz com que as empresas busquem a implantação de métodos de trabalho que viabilizem a resolução de problemas restritivos no sistema de produção, por meio da aplicação dos conceitos do Lean Manufacturing e principalmente das técnicas existentes, dentre elas SMED (Single Minute Exchange of Die), a qual consiste na redução dos tempos de setup através da implementação de melhorias nas trocas de ferramentas. Este estudo tem como objetivo mostrar a aplicação da ferramenta SMED em uma multinacional do setor de autopeças, buscando redução dos custos e melhoria de produtividade. Os resultados obtidos mostraram a eliminação dos desperdícios durante o setup, assim como redução de tempo de preparação de máquina, redução de custos e aumento de produtividade.
Grain morphology and strength dilatancy of sands
Authors: Guida G. , Sebastiani D. , Casini F. , Miliziano S.
Published: February 2019

The presented experimental study, from micro to macro scale, assesses the effects of grain shape on the strength-dilatancy behaviour and physical properties of seven natural sands of different origins and mineralogical composition. The micro-scale has been characterised by processing two-dimensional image of grains, using the fractal analysis of particle contour to define their shape. The macroscopic material properties are evaluated performing direct shear tests at three different normal stresses, and measuring void ratios limit and angles of repose. An innovative method to interpret the experimental data obtained has pinpointed interesting relationships linking the morphological features of grains to the mechanical and physical properties of sands. Data confirm that the increase in grain shape irregularity produces an increase in all the variables investigated: void ratios limit, friction angles and dilatancy parameters.
Water mains’ prioritisation for small to medium-sized utilities of Canada
Authors: Kabir Golam , Demissie Gizachew , Sadiq Rehan , Tesfamariam Solomon
Published: February 2019

Ageing water infrastructure is a major concern for water utilities throughout the world. Due to lack of reliable data, it is challenging to develop an extensive water mains’ renewal programme and predict the performance of water mains. Small and medium-sized water utilities are affected more due to the scarcity of data/information and lack of technical and financial resources. In this study, a life cycle costing (LCC) model is developed for small to medium-sized water utilities of Canada to prioritise repair, rehabilitation and replacement strategies of water mains. The proposed model will guide in establishing a practical and cost-effective renewal programme for new installations or for rehabilitation of damaged water mains. To validate the effectiveness of the LCC model, it is tested and implemented on a medium-sized water utility, namely Greater Vernon Water, British Columbia.
Changes of Phytosterols, Rheology, Antioxidant Activity and Emulsion Stability of Salad Dressing with Cocoa Butter During Storage
Authors: Mohamad Roiaini , Putri Agus Baizura Aya , Hussain Norhayati
Published: February 2019

Addition of phytosterols and antioxidants to food may provide additional health benefits to consumers. Their stability in a food matrix may decrease during storage. Therefore, the objectives of this study are to formulate a salad dressing with cocoa butter and determine its phytosterol stability, antioxidant activity and physicochemical properties during storage. The cocoa butter was extracted using a supercritical CO2 extraction (green technology) and added to the formulated salad dressing (containing different ratios of cocoa butter and soybean oil). The salad dressing with 30 % cocoa butter (the most stable emulsion) was selected for storage study at 4 and 30 °C. However, values of physicochemical parameters and mass fractions of phytosterols, total phenolic compounds (determined using Folin-Ciocalteu reagent) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) in the salad dressing with 30 % cocoa butter decreased during storage (from day 0 to 28) and increased with the temperature increase, probably due to the oxidation of oil. Thus, the most desirable storage temperature for salad dressing was 4 °C. An excellent stability of the salad dressing with 30 % cocoa butter at different storage temperatures for 28 days offers a potential application in food industries for production of salad dressing with cocoa butter enriched with phytosterols.
A Web-Based Tutorial for the Instruction of Spanish Pragmatics
Authors: Russell Victoria , Vásquez Camilla
Published: February 2019

In this paper, we present a Web-based tutorial (WBT), developed forinstruction on Spanish pragmatics. The WBT was designed to teachlearners of Spanish as a foreign language about the speech acts ofcomplaints and requests, and the content of the WBT is based on availableempirical evidence about these speech acts. We describe and illustrate, indetail, the format, structure, and various sections of the WBT, including:lessons, ancillary support, and assessment. In addition, some technicalconsiderations in the development of the WBT, such as the user interfacedesign, are also discussed. The paper concludes with suggestions forimplementing this open access WBT in various teaching contexts, as wellas a discussion of directions for future research. Given the paucity ofmaterials available for the instruction of Spanish pragmatics, either inprint or on the Web, the WBT fills an important gap and provides a modelfor the development of future online pragmatics-focused materials.
Assessing Student Oral Language Proficiency
Authors: Swanson Peter B. , Nolde Patricia R.
Published: February 2019

Second language teachers have an ever increasing abundance oftechnology choices for assessment of student oral proficiency through theadaption of consumer electronics and multimedia devices. The purpose ofthis article is two-fold: (1) to address the benefits and ease of usingdifferent multimedia tools to assess students' oral language proficiencyregardless of grade level and (2) to report the findings of an orallanguage assessment study. Results from the empirical study (N = 128)show that there are manifold benefits of using technology for oralproficiency assessment for both students and instructors. Additionally, thisresearch emphasizes the importance of maximum use of the targetlanguage in the classroom and the importance of aligning assessmentrubrics to the American Council on the Teaching of Foreign Language'sspeaking proficiency guidelines.
The Effectiveness of Smartphone and Tablet PC Apps for Japanese Language Learning
Authors: Ota Fusako
Published: February 2019

The emergence of smartphones and tablet PCs in the second decade ofthe 21 sf century has furthered possibilities for mobile learning. Thecharacteristics of smartphones and tablet PC devices such as affinity,portability, accessibility and the availability of low cost applications(apps) with various functions have transformed these devices into arealistic means of learning. In fact, it has been reported that manysecond language (L2) learners have used such language learning appsand evaluated them positively. The adaptation of mobile apps for L2language education and training has been actively implemented by notonly individual users but also educational and business sectors in manycountries. Thus, this study explores the effectiveness of smartphone andtablet PC apps for Japanese language learning, focusing on learners ofJapanese at a university in Australia. The types of Japanese languagelearning apps that students have used and their usage are examined, inorder to investigate the effectiveness of such apps. This study aims toprovide helpful information to L2 educators and learners about theadaptation of mobile devices to assist their language teaching andlearning.
Legal framework for establishing a single maritime transport space without barriers
Authors: Rukavina Biserka , Rak Loris , Buneta Silvana
Published: February 2019

This paper provides an overview of activities of the European Commission for establishing a single European maritime transport space and indicates whether and to what extent the adopted strategy documents have established their operations in practice. Directive 2010/65/EU of the European Parliament and of the Council on reporting formalities for ships arriving in and/or departing from ports of the Member States and repealing Directive 2002/6/ EC, as well as Directive 2002/59/EC of the European Parliament and of the Council establishing the Community vessel traffic monitoring and information system, which represent significant legislative achievements of the European Union in the process of reducing administrative burdens to which ships are exposed in the maritime transport, are particularly analyzed. Reasons for amending Directive 2002/59/EC are especially explained. In the last part of the paper, authors review the achievements of the Republic of Croatia regarding the implementation of measures for the establishment of a single European maritime transport space. Based on the results of a comparative overview of solutions contained in the Directives and Croatian bylaws, authors point to the existence of non-compliance and to the need for further action.
Diagnóstico da qualidade físico-química do solo sob diferentes usos e manejos no sul de Minas Gerais
Authors: Antunes Cláudia Heluani de Sousa , Portugal Leidiane , Maia João Paulo , Moreira Renata Amato , Silva Bruno Montoani , Santos Walbert Júnior Reis dos
Published: February 2019

Os diferentes sistemas de cultivo causam alterações nas propriedades do solo, com transformações na estrutura, que podem modificar a sua qualidade. Com o propósito de analisar alterações nas propriedades físico-químicas sob diferentes usos da terra em Latossolo Vermelho-Amarelo e Argissolo Vermelho-Amarelo, avaliou-se áreas de produção do IFSULDEMINAS, Campus Muzambinho. Os sistemas de cultivo avaliados foram lavoura cafeeira, monocultivo de milho, pastagem e mata nativa. Os parâmetros analisados foram: densidade do solo (Ds), estabilidade de agregados, teor de matéria orgânica (MO), pH e cálcio (Ca2+). O delineamento experimental foi inteiramente casualizado com quatro tratamentos. Análise de variância foi realizada, sendo as médias dos diferentes tratamentos (uso do solo) comparadas pelo teste Tukey, quando significativo ao teste F. Os resultados obtidos demonstram aumento (P<0,05) na Ds entre as áreas amostradas, na camada de 5-10 cm, observado sobre a área de pastagem. A estabilidade de agregados, expressa por meio do diâmetro médio geométrico (DMG), decresceu (P<0,05) na área de monocultivo de milho comparado aos demais usos. O teor de MO não diferiu (P>0,05) entre os tratamentos, tampouco correlacionou-se com o DMG. Contudo, houve correlação negativa (r=-0,969; P<0,031) entre o DMG e Ca, DMG e pH (r=-0,684; P<0,041) se tratando da área em uso de pastagem. Assim, conclui-se que os diferentes sistemas de cultivo causam alterações nas propriedades do solo, podendo resultar em compactação e implicar no aumento da suscetibilidade a erosão.
PENANAMAN NILAI-NILAI TASAWUF DALAM KELUARGA
Authors: Rahmah St
Published: February 2019

Family is a small community in society. Every Muslim is required to live in order to live the demands of Islamic teachings. The family is the most important unit for the development process of the ummah. a good personality is formed from a family that instills good manners. The concept of family in Islam is quite clear even Islam is very priority of individual and family coaching. Because the family is a good prerequisite for a nation and Country, especially if all families follow the guidelines submitted religion, in addition the family is also the closest environment with children, since children are born, in this family the children will have much experience to grow and developing for the future.  Inside the family parents can give examples of behaviors that will be imitated by children, because in the family is the most effective place to membelajarkan value of religion to the child. The role of parents in the family as guides, caregivers, teachers, mentors, and example in the family. Parents are very big role in inculcating the values of Sufism as the foundation of his children, With the inculcation of the values of mysticism by parents, it is expected that in the next stage of development the child will be able to distinguish good bad, right wrong, so that children can apply it in everyday life
LESBIAN GAY BISEXUAL TRANSGENDER (LGBT) SEBAGAI COSMOPOLITAN PARADOX LIFE STYLE DAN PENANGANANNYA MELALUI PENDIDIKAN TINGGI
Authors: Darmoko Murry
Published: February 2019

This study focuses on Lesbian Gay Bisexuals Transgender (LGBT) which are used as the cosmopolitan life style of today's generation. Evidence of social media shows the rapid development of LGBT members. In Shari'a through religious arguments, LGBT is haram and can be punished until the death penalty and also in LGBT health is considered as one of the causes of HIV-AIDS. However, sociologically, people can accept their presence. LGBT is a paradox of life style in the Muslim community of the world. LGBT is important to be studied, especially related to the pattern of Amar Ma'rûf Nahiy Munkar in Indonesia. Two formulation of the problem, How does the Amar Ma'rfu Pattern prevent LGBT? Second, How does the Nahiy Munkar Pattern overcome LGBT? The purpose of this study answers the two formulations above through Higher Education. Sociology of Law is used as a research approach with qualitative methods because it provides answers. The summary of the research results shows that higher education has a role in fostering LGBT through the socialization of MUI fatwa number 57 of 2014 and applying ant and bee patterns in implementing the Anti LGBT Campus Program through the teaching and learning process that explains LGBT in terms of religion and health and anti-campaign LGBT when implementing community service learning. Penelitian ini fokus pada Lesbian Gay Bisexual Transgender (LGBT) yang dijadikan sebagai kosmopolitan life style generasi masa kini. Bukti media sosial menunjukkan perkembangan pesat anggota LGBT. Secara syariat melalui dalil-dalil agama, LGBT adalah haram dan dapat dipidana sampai hukuman mati dan juga dalam kesehatan LGBT dianggap sebagai salah satu penyebab HIV-AIDS. Walaupun begitu, secara sosiologi, masyarakat dapat menerima kehadiran mereka. LGBT menjadi paradox life style dalam masyarakat muslim dunia. LGBT penting diteliti, terutama berkaitan dengan pola Amar Ma’rûf Nahiy Munkar di Indonesia. Dua rumusan masalah, Pola Amar Ma’rûf  yang bagaimana dapat mencegah LGBT? Kedua, Pola Nahiy Munkar yang bagaimana dapat mengatasi LGBT? Tujuan penelitian ini menjawab dua rumusan di atas melalui Pendidikan Tinggi. Sosiologi Hukum dijadikan pendekatan penelitian dengan metode kualitatif karena memberikan jawaban. Ringkasan hasil penelitian menunjukkan pendidikan tinggi berperan dalam membina LGBT melalui sosialisasi Fatwa MUI nomor 57 tahun 2014 dan menerapkan pola semut dan lebah dalam melaksanakan Program Kampus Anti LGBT melalui proses belajar mengajar dengan kewajiban menempuh mata kuliah yang menjelaskan LGBT dari sisi agama dan kesehatan serta kampanye anti LGBT saat pelaksanaan KKN di masyarakat.
Determinações iodométricas
Authors: Andrade João Carlos de
Published: February 2019

Os métodos volumétricos que utilizam reações de oxidação e redução dependem dos potenciais das semi-reações envolvidas mas, além dos potenciais favoráveis, os agentes oxidantes e redutores devem ser estáveis em solução e a substância a ser determinada deve ser colocada sob um determinado estado da oxidação, definido e estável, antes da titulação ser iniciada A iodometria é um método volumétrico indireto, onde um excesso de íons iodeto são adicionados à uma solução contendo o agente oxidante, que reagirá produzindo uma quantidade equivalente de iodo que será titulado com uma solução padronizada de tiossulfato de sódio.
Voltametria: conceitos e técnicas
Authors: Aleixo Luiz Manoel
Published: February 2019

Nesse texto serão introduzidos os principais métodos voltamétricos de análise, abordando-se desde seus aspectos básicos até aplicações em análise de traços. Serão apresentadas as técnicas voltamétricas (polarográficas) de corrente contínua (DC, do inglês direct current), corrente contínua amostrada (DC sampled), pulso normal (NP, do inglês normal pulse), pulso diferencial (differential pulse) e onda quadrada. Na utilização da voltametria em análise de traços serão discutidos os métodos de voltametria de redissolução anódica/catódica e de voltametria adsortiva por redissolução. Também serão tratados aspectos relacionados ao efeito da matriz e validação de métodos.
PENDIDIKAN AKHLAK KEPADA ANAK DENGAN METODE HABITUASI (Kajian Hadits Dalam Perspektif Psikologi)
Authors: Umami Idail Uzmi Fitri
Published: February 2019

Moral education for children is very important because children are the next generation of religion, nation and state, imagine how a country would become if its successor or leader does not have morals and morals, of course, what happens is chaos in that country. Moral education for someone should be early because morality is the embodiment of personality that is nurtured from the beginning, fostering good moral character for children certainly starts from the smallest environment of his life, namely the family environment. But the problem that arises is how to educate children correctly and effectively, a term known in children’s temperament is the tabula rasa expression which means the child is born like blank paper and innocently does not have any scribble at all that the child carries nothing when born, so this It is the duty of parents to direct their children to the right path or to the wrong road.
Facebook y comunicación virtual. Un estudio experimental en docentes de educación superior
Authors: Fajardo Vizquerra Leydi Susan , Alarcón Diaz Mitchell Alberto , Alcas Zapata Noel , Alarcón Diaz Henry Hugo
Published: February 2019

El presente estudio tuvo como objetivo determinar el efecto de un programa de capacitación Facebook en la comunicación virtual de docentes universitarios. La importancia de la temática desarrollada se fundamenta ya que en los momentos actuales, para el proceso de interacción y comunicación entre las comunidades laborales, académicas, económicas o sociales, se está haciendo uso de las Tecnologías de la Información y la Comunicación (TIC), en donde fluye todo tipo de información a través de las herramientas tecnológicas disponibles y redes sociales, y que es seleccionada por los usuarios, según el grupo de interés al que pertenecen; uno de ellos es facebook.  El enfoque fue  cuantitativo, con diseño cuasi- experimental, para los cual se trabajó con una muestra de 140 docentes universitarios distribuida en dos grupos: control con 60 docentes y el segundo grupo experimental constituido por 80 docentes. Los resultados indican que existe influencia del programa de capacitación Facebook  en la comunicación virtual de los docentes universitarios, como se demuestra con la prueba estadística (U de Mann-Whitney = 155.500; Z = -1.084; Sig. Asintótica (bilateral) .000<.05). Este hallazgo, puede ayudar a generar opiniones favorables para su posible utilización de la plataforma Facebook con fines de interacción social educativa.
El Aprendizaje Basado en Problemas (ABP) en el desarrollo de la inteligencia emocional de estudiantes universitarios
Authors: Luy-Montejo Carlos
Published: February 2019

El presente artículo trata sobre el efecto del Aprendizaje Basado en Problemas (ABP) en el desarrollo de la inteligencia emocional de estudiantes del primer ciclo en una universidad privada de Lima. Para lograr este propósito se realizó una investigación de tipo aplicado, empleando el método experimental (diseño cuasi-experimental), dado que se manipulará la variable independiente (ABP) para que produzca un efecto sobre la variable dependiente (Inteligencia Emocional), la cuál será medida. Para ello, se tomó una muestra de 48 estudiantes distribuidos en dos grupos: uno de control (24) y otro experimental (24) de una población total de 1281 ingresantes. Para la recolección de datos, se empleó el test de Inventario de Inteligencia Emocional de Bar-On (I-CE) como prueba de entrada (pretest), aplicándose la metodología del ABP durante 16 sesiones de aprendizaje al grupo experimental, mientras que para el grupo de control se utilizaron metodologías de aprendizaje tradicionales; para luego efectuarse las mediciones con el mismo test de BarOn como prueba de salida (postest) para ambos grupos. Los resultados mostraron que hubo influencia significativa del ABP en el desarrollo de la inteligencia emocional de los estudiantes objeto del estudio.
А САSЕ OF SPONTANEOUS CORONARY ARTERY DISSECTION (REVIEW AND CASE REPORT)
Authors: Vatutin N. T. , Taradin G. G. , Bort D. V. , Dmitriev A. V. , Kanisheva I. V. , Sidorenko I. A.
Published: February 2019

The article presents a literature review on the problem of spontaneous dissection of the coronary artery (SCAD) — tearing of its wall, not associated with atherosclerosis, trauma or iatrogenic effects leading to blood penetration between vessel layers of the artery. The consequence of this dissection is obstruction of the coronary artery due to the formation of intramural hematoma or intima damage, and myocardial ischemia with development of acute coronary syndrome, myocardial infarction or sudden cardiac death. Information on the epidemiology, pathophysiology andetiology of the disease is presented here. It was highlighted a role of arteriopathies, inflammatory diseases, pregnancy and female sex hormones, genetic causes as well as initiating and stress factors in its development. The clinic picture and diagnosis of the disease is described. It was emphasized that in addition to clinical manifestations, the traditional electrocardiogram and coronary angiography remain the standard for diagnostics of the dissection. In the treatment of SCAD, percutaneous coronary intervention with stenting of the affected artery is used, coronary artery bypass surgery and medications with regard to preference of conservative drug therapy. A special attention is paid to the features of diagnostic and therapeutic measures in pregnant and breast-feeding patients. The article also presents a clinical case of development of large-focal myocardial infarction complicated by cardiogenic shock in a young woman without risk factors for coronary heart disease in the postpartum period caused by SCAD. Diagnosis of the disease was accompanied by certain difficulties. An urgent percutaneous coronary intervention with stenting of the infarct-related coronary artery allowed rapidlyimproving and stabilizing the patient’s condition.
CHRONIC PHARYNGITIS: ETIOLOGY, PATHOGENESIS, TREATMENT. NEW APPROACHES TO THE ESTIMATION OF ETIOPATOGENESIS
Authors: Gostry A. V. , Simonova A. V. , Mikhailova N. A. , Snimshchikova I. A. , Osipov G. A. , Agafonov B. V. , Egorov V. I. , Pchelyakova V. V. , Gorenkov R. V. , Chudakov S. Yu. , Karabinenko A. A. , Shevtsova N. N. , Arkhipov I. V. , Simonov D. V.
Published: February 2019

The work discusses modern issues of etiopathogenesis, treatment of chronic pharyngitis. The results of the application of a modern method for the diagnosis of mass spectrometry of microbial markers (MSMM), which allows to detect the microorganisms in a biofilm, in a “sleeping state” under the protection of mucin are presented. With the help of this express method, it is possible to conduct a determination of the content in a smear from the pharynx 57 biomarkers of microorganisms at the same time 2 hours after delivery to the laboratory. It was found that 100% of the examined patients with a recurring course of HF (n = 62) increased the total content of microorganisms, which indicates the need for antibacterial therapy; 87% of patients have elevated levels of endotoxin, which is a sign of general intoxication; 71% of patients have reduced plasmalogene content and these patients may be at increased risk for lipid metabolic disturbances; in 100% of the examined patients with frequent exacerbations of CP in the pharynx the nasopharyngeal microflora (coccal) is determined, as well as new etiopathogenetically significant microorganisms (not detected by PCR and cultures), among which there are 7 transient microorganisms (normally in the orifice their level = 0), 11 resident (6- found in the throat in the norm in the minimum level and 5 in the high content). Also, with the help of MSMM, a significant or moderate increase in the content of herpes, cytomegalovirus was detected in the majority (75%) of patients, which indicates the important role of the viruses of the herpes group in the etiopathogenesis in the recurrent course of CP; level of Candida spp. elevated in half of patients; the content of normal microflora is increased in 71% of patients, which indicates the preservation of local resistance in patients with chronic HF, examined by the authors. Thus, the use of MSMM for chronic fever allows to identify new etiopathogenetic microorganisms, on this basis to prescribe a more effective therapy. Thus? it is possible to carry out personified, more effective treatment.
Contactless In Situ Electrical Characterization Method of Printed Electronic Devices with Terahertz Spectroscopy
Authors: Zhuldybina Mariia , Ropagnol Xavier , Trudeau Charles , Bolduc Martin , Zednik Ricardo J. , Blanchard François
Published: February 2019

Printed electronic devices are attracting significant interest due to their versatility and low cost; however, quality control during manufacturing is a significant challenge, preventing the widespread adoption of this promising technology. We show that terahertz (THz) radiation can be used for the in situ inspection of printed electronic devices, as confirmed through a comparison with conventional electrical conductivity methods. Our in situ method consists of printing a simple test pattern exhibiting a distinct signature in the THz range that enables the precise characterization of {the static} electrical conductivities of the printed ink. We demonstrate that contactless dual-wavelength THz spectroscopy analysis, which requires only a single THz measurement, is more precise and repeatable than the conventional four-point probe conductivity measurement method. Our results open the door to a simple strategy for performing contactless quality control in real time of printed electronic devices at any stage of its production line.
Structural Perspective on Revealing and Altering Molecular Functions of Genetic Variants Linked with Diseases
Authors: Peng Yunhui , Alexov Emil , Basu Sankar
Published: February 2019

Structural information of biological macromolecules is crucial and necessary to deliver predictions about the effects of mutations—whether polymorphic or deleterious (i.e., disease causing), wherein, thermodynamic parameters, namely, folding and binding free energies potentially serve as effective biomarkers. It may be emphasized that the effect of a mutation depends on various factors, including the type of protein (globular, membrane or intrinsically disordered protein) and the structural context to which it occurs. Such information may positively aid drug-design. Furthermore, due to the intrinsic plasticity of proteins, even mutations involving radical change of the structural and physico-chemical properties of the amino acids (native vs. mutant) can still have minimal effects of protein thermodynamics. However, if a mutation causes significant perturbation of either folding or binding free energies, it is quite likely to be deleterious. Mitigating such effects is a promising alternative to the traditional approaches of designing inhibitors. This can be done by structure-based in silico screening of small molecules for which binding to the dysfunctional protein restores its wild type thermodynamics. In this review we emphasize on the effects of mutations on two important biophysical characteristics, stability and binding affinity, and how structures can be used for structure-based drug design to mitigate the effects of disease-causing variants on the above biophysical characteristics.
Utility Approaches to Evaluating the Effectiveness of Consumer Confidence Reports
Authors: Evans Jessica , Carpenter Adam
Published: February 2019

The Safe Drinking Water Act Amendments of 1996 require community water systems in the United States to send consumers Consumer Confidence Reports (CCRs). CCRs contain information on detected contaminants and required educational information about drinking water. The authors of this study developed a survey to evaluate how utilities track consumer feedback, understanding, and the role of the CCR in shaping consumer perceptions about water quality. Responses from this survey indicate it is common for utilities to indirectly track the effectiveness of their CCRs, but few utilities indicated directly evaluating consumer understanding or the effect of CCRs on consumer perceptions.
A Modified Methodology for Generating Indoor Navigation Models
Authors: Lewandowicz Elżbieta , Lisowski Przemysław , Flisek Paweł
Published: February 2019

Automatic methods for constructing navigation routes do not fully meet all requirements. The aim of this study was to modify the methodology for generating indoor navigation models based on the Medial Axis Transformation (MAT) algorithm. The simplified method for generating corridor axes relies on the Node-Relation Structure (NRS) methodology. The axis of the modeled structure (corridor) is determined based the points of the middle lines intersecting the structure (polygon). The proposed solution involves a modified approach to the segmentation of corridor space. Traditional approaches rely on algorithms to construct Triangulated Irregular Networks (TINs) by Delaunay triangulation or algorithms for generating Thiessen polygons known as Voronoi diagrams (VDs). In this study, both algorithms were used in the segmentation process. The edges of TINs intersect structures. Selected midpoints on TIN edges, which are located in the central part of the structure, are used to generate VDs. Polygon VDs segment corridor structures. The identifiers or structure nodes are the midpoints on TIN edges rather than the calculated centroids. The generated routes are not zigzag lines, and they approximate natural paths. The main advantage of the proposed solution is its simplicity which can be attributed to the use of standard tools for processing spatial data in a geographic information system.