bluuebunny/crossref_metadata_2025 huggingface dataset:
FEATURES OF CALCIUM HOMEOSTASIS AND CALCIUM SIGNALING IN NEURONS
Authors: Кайрат Б.К. , Тулеуханов С.Т. , Зинченко В.П.
Published: August 2021

Ионы Са являются основным мессенджером в регуляции физиологических функций клеток. Внутриклеточном пространстве ионы Ca могут свободно состоянии диффундироваться в различных частях цитоплазмы, в то же время значительное количество Ca в связанном виде накапливается в различных внутриклеточных депо или в составе кальций-связывающих белков. Регуляция физиологических процессов с ионами внутриклеточного Са происходит в диапазоне концентраций 10 М, тогда как концентрация Са во внеклеточном пространстве выше и составляет 10 М, для поддержании градиента концентраций в клетках имеются важные Са транспортирующие системы плазматической мембраны, эндоплазматического ретикулума и митохондрий. В нейронах функционируют внутриклеточные ферменты и белки плазматической мембраны для поддержания Са-гомеостаза и реализации механизмов внутриклеточной сигнализации для обеспечения жизнедеятельности в выживании клеток. Нарушение или гиперактивация одного или нескольких механизмов кальциевой сигнализации может привести к повреждению и гибели нейронов в случае отсутствия компенсаторных механизмов.

Ca ions are a key messenger for the regulation of most of the physiological functions of cells. Inside the cell, Ca ions can freely diffuse in various parts of the cytoplasm, but a significant amount of Ca is also bound in various intracellular depots or in the form of calcium-binding proteins. The regulation of physiological processes by intracellular Ca ions occurs in the concentration range of 10 M, and the concentration of Ca in the extracellular space is higher and is 10 M, and to maintain this concentration gradient, cells have Ca-transporting systems of the plasma membrane, endoplasmic reticulum and mitochondria. In neurons, a large number of intracellular enzymes and plasma membrane proteins function to maintain Ca-homeostasis and implement intracellular signaling mechanisms to ensure vital activity in the survival of cells. Violation or hyperactivation of one or more mechanisms of calcium signaling can lead to cell damage and death in the absence of compensatory mechanisms.
PARENTAL ATTITUDES TOWARDS VACCINE PREVENTION DURING THE COVID-19 PANDEMIC
Authors: Абдураим А.Д. , Абибуллаев Б. , Басыгара К.К. , Сабит Б.М. , Тлеукул Ф.К. , Сейдакпар Ж.П. , Бейсембинова Н. О. , Давлетгильдеева З.Г.
Published: August 2021

Целью данного исследования было изучить отношение родителей к вакцинации детей. Меры вакцинопрофилактики для предотвращения распространения инфекционных заболеваний всегда горячо обсуждаются среди населения, и эта тема становится все более актуальной во время нынешней пандемии COVID 19. В настоящее время растет число родителей отрицательно относящихся к вакцинации, и это обусловливает растущую необходимость уделять особое внимание и повышению качества проведения санитарно-просветительских работ среди данной группы населения.

The aim of this study was to examine the attitude of parents towards vaccination of children. Vaccine prevention measures to prevent the spread of infectious diseases are always hotly debated among the population, and this topic becomes more and more relevant during the current COVID 19 pandemic. Currently, there is an increasing number of parents who have a negative attitude to vaccination, and this leads to a growing need to pay special attention and improve the quality of delivery of sanitary and educational work among this population group.
Avaliando aprendizado de máquina na previsão de curto prazo de séries temporais de energia solar
Authors: Fraccanabbia Naylene , Mariani Viviana Cocco
Published: August 2021

Fontes alternativas de energia estão se tornando cada vez mais frequentes, tendo como objetivo reduzir a poluição ambiental, além de serem ideais para superar a crise energética, logo, neste contexto, a energia solar se destaca por ser abundante. Devido ao alto nível de incerteza dos fatores que interferem diretamente na geração de energia solar, como temperatura e radiação solar, realizar previsões de energia solar com alta precisão é um desafio. Assim, o objetivo deste artigo é desenvolver um modelo de previsão por meio de séries temporais que possibilite prever a produção de energia solar, para 1, 3 e 6 passos à frente, enfatizando a potencialidade da rede neural, utilizando um banco de dados de uma usina fotovoltaica localizada no Uruguai. Para o desenvolvimento da proposta, técnicas de pré-processamento e os métodos de previsão regressão de vetores de suporte (Support Vector Regression, SVR), rede neural perceptron multicamadas com regularização bayesiana (Bayesian Regularized Neural Network, BRNN) e modelo linear generalizado (Generalized Linear Model, GLM) foram combinados. Por fim, tais combinações foram comparadas usando medidas de desempenho. Notou-se que a combinação da análise de componentes principais (Principal Components Analysis - PCA) e a Rede Neural Perceptron Multicamadas com Regularização Bayesiana obteve os melhores resultados, utilizando as três medidas de desempenho.
Examination of Mental Training and Mental Toughness in Elite Boxers
Authors: Sural Volkan , Güler Hasan , Çar Bekir
Published: August 2021

Background: Mental training and toughness play an important role as well as physical training and toughness in increasing the performance of an athlete. Aim: This study aimed to i) evaluate the mental training and mental toughness levels of elite boxers in terms of various variables, ii) examine the relationship between mental training and mental toughness levels, and iii) investigate the predictive level of mental toughness levels of mental training levels. Methods: The sample of the study consisted of 191 elite boxers. The data of the study were collected with the online questionnaire method using the Mental Training Inventory in Sports and the Mental Toughness Inventory in Sports. SPSS package program was preferred for data analysis and independent samples t-test was used for pairwise comparisons and one-way analysis of variance was used for multiple comparisons. Pearson Product Moments Correlation Coefficient (r) was used to test the relationship between mental training and mental toughness in elite boxers, and linear regression analysis was used to determine the ratio of mental training to predict mental toughness level. Results: While the digital game playing level of secondary school students was low, their level of loneliness was found to be moderate, and it was determined that there was a significant and negative difference between digital game addiction and loneliness. A statistically significant difference was found between the levels of Digital Game Addiction (DGA7) and the variable of gender, presence of digital devices, and daily digital game playing status. However, it was concluded that there was a statistically significant difference between the perceived loneliness levels of the participants and their gender, age, income status, and availability of digital devices. Conclusion: As a result, while the mental training levels of elite boxers differed significantly according to age and being national athlete status, there was no difference according to gender. Mental toughness levels differed significantly according to age categories, but there was no difference according to gender and being national athletic status. There was a positive and significant relationship between the mental training levels of elite boxers and their mental toughness levels. Moreover, it was concluded that the mental training levels of elite boxers were a significant predictor of their mental toughness levels (34%). This result showed that the athletes who want to increase their mental toughness levels should do mental training. Keywords: Mental Training, Mental Toughness, Elite Boxers.
Reduction in Glomerular Filtration Rate Following Live Kidney Transplant Donor
Authors: Akbar Afsheen , Raza Maryam , Zia Amtul Huda,Sadia , Naz Shaheena , Zaidi Aasma Nighat , Ali Zulfiqar
Published: August 2021

Aim: Renal replacement therapy is best possible treatment for end stage renal failure, but current research suggestive of augmented long-term risk in renal function for the donor. Methods:At this time, we evaluate the subjects for the risk of decreased (eGFR) estimated glomerular filtration rate within old 50 giver, who undergo pre-donation assessment and live benefactor nephrectomyamong 2007 and 2015by multiple centers of Pakistan. Results:The mean pursuepoint in time was 8.5 years (0.9–28.2). Inco relational analysis, subject age and status of hypertension (arterial) by thereference line were considerablylinked witha elevatedhazard of unfavorable renal effect, in particular, eGFR <60mL/min/1.73m2 (age/year: hazard ratio (HR) 1.03, 95% confidence interval (CI) 1.04–1.08, (HTN): HR 1.09, 95% CI 1.21–4.0), eGFR <60 mL/min/1.73 m2 and a turn down of _39% from the initial measured line (age: HR 1.07, 95% CI 1.03–1.13,HTN: HR 4.22, 95% CI 1.71–10.35), and, eGFR <45mL/min/1.73m2. Age and HTN HR 2.13, 95% CI1.04–1.21, HR 4.05, 95% CI 1.47–18.15 respectively, Adding together, eGFR levels at occasion of contribution was linked with a lesserhazard of eGFR <60 mL/min and eGFR <40 mL/min. The only significantpredictor for adverse renal outcomes was Age. Conclusion: Arterial hypertension, lower level of eGFR, and age at the time of donation are powerful prognosticating factor for undesirable kidney adverse effects in live renaldonor. Keywords: eGFR (per mL/min/1.73 m2) Estimated glomerular filtration rate, arterial hypertension HTN; ESRD
Documented Lipid Per oxidative Intoxication of Cerebellar Molecular Cell Layer
Authors: Amjad Zaheer , Kohari Tazeen , Malick Zaffar
Published: August 2021

Background: Cerebellar cortexconsists of three layers. The outer molecular, middlePurkinje cell layer, inner granule cell layer. Lithium the alkali metal hasdeleterious effects on nervous tissue and this study proved the injurious effects of lithium on molecular cell layer of cerebellum. Aim: To observe and report the damaging histological and morphological change of the decrement in the thickness of cerebellar molecular layer by Lithium. Methods: This study was designed to observe the microscopic changes of thickness of molecular layer in rat cerebellum. For this experimental study 12 animals were used, they were divided into two groups, each comprising of 6 animals. Results: Group-A received normal lab diet and water ad libitum while group B received injectable lithium carbonate 20 mg/kg/ for 4 weeksrespectively. Micrometry was done and changes of the thickness of molecular cell layer were recorded and documented. Conclusion: The pernicious effects of Lithium Carbonate on molecular cerebellar cortex were visualized and evaluated .Highly significantly decreased changes of thickness of molecular cell layer were documented in rat cerebellum. Keywords: Lipidperoxidation,Molecular cell layeratrophy, decomposition
Factors for In-hospital Mortality after Percutaneous Coronary Intervention in Patients with ACS
Authors: Farooqi Muhammad Asif , Malik Bilal Rafique , Ilyas Aneeqa
Published: August 2021

Background: Percutaneous coronary intervention (PCI) is a nonsurgical technique for treating obstructive coronary artery disease. Aim: To assess the causes / factors leading to mortality after percutaneous coronary intervention Study design: Cross sectional study Setting: Department of Cardiology, Punjab institute of cardiology, Lahore. Duration: Six months i.e. from1stJuly 2020 to 31stDecember 2020. Methods: Medical records of 100 cases who dies after PCI for acute coronary syndrome were taken from record center. Medical record of patients aged 40 to 70 years, both genders underwent PCI and did not survived after PCI were included. Location of lesion, and severity of vessel disease, type of procedure and acute renal failure were considered as factors of mortality and were noted on proforma while analyzed in SPSS 20. Results: The mean age of the patients was 54.20 ± 8.84 years. There were 42(42%) males and 58(58%) females. History of smoking was positive in 48 (48%) cases, diabetes in 51(51%) and hypertension in 55(55%) cases. Among the factors, old age (≥50 years) was observed in 64(64%) patients while 36(36%) had age <50 years. There were 39(39%) patients who underwent PCI under emergency situation and 61(61%) patients had PCI under elective circumstances. Acute renal failure was noticed in 37(37%) patients. There were more patients of right coronary artery disease i.e. 54(54%) who underwent PCI. Conclusion: Out of all factors leading to mortality after PCI, older age at the time of PCI is the most common factor, followed by right coronary artery disease and multi-vessel disease. Keywords: Mortality, PCI, angiography, cardiovascular complications
CELLULASE AND ITS ROLE IN INDUSTRIES: A REVIEW
Authors: Singh Vijay Pratap , Sharma Divya
Published: August 2021

Cellulose is the most abundant polymer present in various agricultural wastes. These wastes can be converted into useful products by degradation of cellulose present inside these wastes. The conversion is catalysed by cellulase enzyme. This review describes the bacterial cellulase enzyme including their classification, isolation, production and applications. In this, we have mentioned the isolation and screening techniques of bacterial cellulase along with some other microbial species, which are having potential of producing cellulase enzyme. It also discusses the submerged and solid-state
production of cellulase enzyme along with applications in textile, paper, production of biofuel, food and animal feed industry, oil extraction, brewing, and agriculture. Now a days, industrial enzymes achieved a great place due to their easy production from cheap agricultural wastes together with their magnificent role in above mentioned industries. These features attract the industries, so that they can make their products economically valuable and also improve the protocols accordingly.
BACTERIAL AND FUNGAL CONTAMINANTS OF TISSUE-CULTURED 'LAKATAN' BANANA
Authors: Hindoy Jr. Carlito M. , Magbalot-Fernandez Alminda , Ubaub Leslie T. , Basu Saikat K.
Published: August 2021

This study aimed to characterize the bacterial and fungal contaminants of tissue-cultured 'Lakatan' banana (Musa acuminata) during initiation stage. This was conducted at the University of Southeastern Philippines, Tagum-Mabini Campus from October 2015 to February 2016. The sterilized banana explant was placed in a bottle of solidified nutrient agar medium. Detectable bacterial and fungal contaminants were isolated and sub-cultured into the fresh medium two to four days after incubation. The bacterial isolates were cultivated by streaking into fresh culture medium and incubated at 0 0 30-32 C for three days and fungi culture disk was transferred to fresh culture medium and incubated at 30-32 C for three to five days. Both bacterial and fungal contaminants were identified and characterized and assessed for extent of contamination. Results showed that the different contaminants occurred during the initiation stage of tissue-cultured 'Lakatan' banana meriplants were composed of Rhizopus sp., unidentified fungus and Gram-negative bacterium. Generally, 35% contamination was observed on this stage.
STANDARDIZATION THE EFFECT OF PLANT GROWTH REGULATORS ON IN VITRO PROPAGATION OF BANANA (MUSA SPP) EXPLANTS: A REVIEW
Authors: Pravalika Kothula
Published: August 2021

Banana (Musa spp.) is a large herbaceous perennial monocotyledonous and monocarpic plant. It belongs to the family Musaceae. Banana is one of the popular berry fruit which is available to every common person. Banana crop is mostly cultivated through sword suckers, for ease production some in vitro propagation methods came into existence
like tissue culture technology. Some of them are micro propagation, clonal propagation etc, For in vitro growth of the excited tissues, plant growth regulators have been considered as one of the most significant factor. Most commonly, auxins and cytokinins are used in the growth and development of the banana explants. The plant growth regulators are required in different concentrations along with Murashige and Skoog media for the best shooting and rooting of the explants.
GROWTH PERFORMANCE OF TISSUE-CULTURED ´LAKATAN´ BANANA (MUSA ACUMINATA) PLANTLETS USING STIMULANTS
Authors: Magbalot-Fernandez Alminda , Matuguinas John Paul L. , Basu Saikat K.
Published: August 2021

The study aimed to determine the effects of stimulants on the growth performance of tissue-cultured 'lakatan' banana plantlets (Musa acuminata) under nursery condition; to determine the best treatment combination that will increase the growth performance of tissue-cultured 'lakatan' banana plantlets; and to determine the economic benefits of using stimulants in tissue-cultured 'lakatan' banana plantlets.
The study was laid out in a Complete Randomized Design (CRD) with seven treatments and replicated thrice with eight samples per replicate. The treatments were; T1- Control (No Application); T2- Conventional Practice (CP) (5 grams N-PK every 15 days); T3- Bio-Forge (5 ml/ liter water foliar application); T4- CP + Bio-Forge (0.125 grams of N-P-K + 5
ml of Bio-Forge/ liter water); T5- CP + Stimulate (5 grams of N-P-K + 10 ml of Stimulate/ liter water); T6- Bio-Forge + Stimulate (5 ml of Bio-Forge/ L. of water + 10 ml of Stimulate/liter water); T7- CP+ Bio-Forge+ Stimulate (5 grams of N-P-K + 5 ml of Bio-Forge/ liter water + 10 ml of Stimulate/ liter water). All data were analyzed through Analysis of Variance (ANOVA) and differences among treatments were computed using Honest Significant (HSD) test.
The results of the study revealed that the percentage of survival and pseudostem diameter at 15 Days after planting (DAP) was not significantly affected by different treatments. Plant height, length of leaves, width of leaves, pseudostem diameter (30 & 45), number of leaves, root length and number, fresh and dry weights at 15, 30 and 45 DAP have significant effects. The T7 - (Conventional Practice + Bio-Forge + Stimulate) significantly increased plant height by 7 times, width of leaves by 3 times, stem diameter by 6 times, root number by 3 times, fresh weight by 17 times which were comparable with T6- (Bio-Forge + Stimulate), T5- (CP + Stimulate), T4- (CP + Bio-Forge) and T3- (BioForge).
The T3 (Bio-Forge) had the highest leaf length increase by 10 times, root length by 100% which is comparable to T5- (CP + Stimulate), T6- (CP + Stimulate) and T7- (CP + Bio-Forge + Stimulate). While T4- (CP + Bio-Forge) had the heaviest dry weight by 28 times which is also comparable to T3 (Bio-Forge), T5 (CP + Stimulate), T6 (Bio-Forge + Stimulate) and T7- (CP + Bio-Forge + Stimulate).
AN ASSESSMENT OF EDIBLE COATING AND ITS IMPACT ON SHELF LIFE AND POST HARVEST QUALITY OF GUAVA (PSIDIUM GUAJAVA L.) FRUITS – A REVIEW
Authors: Shaifali Shaifali
Published: August 2021

Legitimate postharvest treatment of food produces is a higher priority than the serious and broad cultivating in making sure about nourishment for a country, since misfortunes are a misuse of food as well as they speak to a comparable misuse of human exertion, ranch inputs, jobs, speculations and scant recourses, for example, water. Postharvest misfortunes of agricultural yields when all is said in done and new products of the soil (perishables) specifically are normal issues in creating nations, similar to Ethiopia, which negatively affects the food security program. This is mostly
a direct result of their transitory nature, absence of information and deficiency of capital. The other explanation is that a large portion of these perishables are delivered by little scope ranchers the individuals who have restricted information and monetarily poor in the creating nations. Along these lines, assessment of postharvest misfortunes of new foods grown from the ground is exceptionally significant for mindfulness creation to deal with the produce appropriately in order to spare from waste and harms by physical and physiological methods. The destinations of this audit are, hence, to
evaluate the accessible writings on the postharvest misfortunes of new foods grown from the ground trying to distinguish need zones of the issue; to distinguish the reasons for misfortunes of perishables so as to dodge the foundations for the decrease of misfortunes; and to distinguish the potential methodologies that can decrease misfortunes and keep up nature of the items during the period.
TISSUE CULTURE AS A PLANT PRODUCTION TECHNIQUE FOR FRUIT CROPS AND PLANT PART USED FOR PROPAGATION
Authors: Rodge Rahul R. , Patil Pravin
Published: August 2021

The culture of plant tissue refers to the growth and multiplication in aseptic and regulated environments of cells, tissues and plant organs on specified solid or liquid media. In the fields of agriculture, horticulture, forestry and plant breeding, plant tissue culture has been commonly employed. it is an applied biotechnology used for mass proliferation, extinction of viruses, development of secondary metabolites and In-vitro cloning of plants. Plant tissue culture, slow growth and cryopreservation, also known as long-term preservation are also known as, has been extensively used for the preservation of endangered plant species., through short and medium-term conservation. In a suitable culture medium, a whole plant may be regenerated from a small tissue or plant cell. under controlled environment. Commercial technology is mostly based on micro propagation, where rapid proliferation is performed from process cuttings, axillary buds, somatic embryos, cell clumps in suspension cultures, and bioreactors to a small degree.
CASE STUDY: EFFECTS OF UNANI MEDICINE ON ATOPIC DERMATITIS
Authors: Kawoosa Shahnaz Hafeez
Published: August 2021

Atopic Dermatitis is an endogenous eczema triggered by exogenous agents and characterized by:
Extremely pruritic, recurrent symmetric eczematous lesions. Site of involvement depending on the age of the patient. Personal and family history of allergic rhinitis, asthma, hay fever. Increased ability to form IGE to common environmental allergens (1).
Atopic Dermatitis is a common, often persistent skin disease that affects a large percentage of world's population. The term Atopic is from the Greek meaning 'strange'. The word Dermatitis means inflammation of the skin (2).
SCOPE OF UNANI MEDICINE IN THE PROPHYLAXIS AND MANAGEMENT OF COVID-19
Authors: Shamsi Yasmeen , Rahman Rais Ur , Akhtar Md. Wasi
Published: August 2021

Coronavirus disease (COVID-19) is an acute infectious disease caused by infection with a novel coronavirus SARSCoV-2. The disease severity can range from mild to developing into critical with pneumonia and even life-threatening complications such as Acute Respiratory Distress Syndrome (ARDS), shock, or multi-organ system dysfunction. The
clinical picture of Nazla-e-Wabaiya is almost similar to that of Covid-19 like body ache, sore throat, nasal irritation, burning sensation in eyes sneezing, cough, and fever. As per the Unani scholars, the prophylaxis and management include various single and compound drugs to be used orally. They also prescribed various drugs as disinfectants to be used for fumigation, incense, and spray. Ibn Sina advised that houses should be sanitized daily by spraying Arq Gulab (Rosa damascene), Arq Bed Sada (Salix caprea), or Arq Nilofer (Nymphaea alba) and recommended Bukhoor (incense) of Sa'ad Kufi (Cyperusrotundus), Habb-ul-Aas (Myrtuscommunis), Kundur (Boswelliaserrata), and
Sandalwood (Santalum spp.). For the treatment of Nazla-e-Wabaiya, the decoction (Joshanda) of Unnab, Sapistan, and Behidana along with Sharbat Banafsha have been recommended by many eminent Unani scholars. They have also recommended using various types of Khamiras like Khamira Gaozaban, Khamira Abresham SheeraUnnabWala, Khamira Marwareed to improve general health and immunity.
A Measurement Model of Organisational Culture as Perceived by Staff at the Islamic University in Uganda
Authors: Miiro Farooq , Burhan Mohd
Published: August 2021

Organizational culture plays a pivotal role in the development and change of organizations. To achieve institutional competitiveness and repositioning on the world market all key players in the institutional development need to be on the same page in terms of organizational culture. A mammoth of studies have been done in the past to explore organizational culture structure but there were no attempts done to validate and measure the construct on employee behaviour and thoughts at the Islamic University in Uganda. The purpose of this study therefore is to measure and validate organisational construct as perceived by staff at the Islamic University in Uganda. The study employed four dimensions to examine organizational culture, and 361 staff through randomization participated in the study. To arrive at the intention of the study SEM-Amos technique of data analysis was used to confirm the hypothesized measurement model. The results indicated that meaningful value, support and promotion of values, discipline values and free style value are true and valid predictors of organizational culture structure.
Human Resources Recruitment and Selection Practices in Nigerian Organisations
Authors: Rotimi Adeyoriju , Folorunso Fajebe
Published: August 2021

This study examined human resources recruitment and selection practices in Nigerian organizations. To achieve this, literature were reviewed on recruitment and selection practices, current trends on recruitment and selection in Nigeria workplace, challenges and consequences of poor recruitment and selection practices, along with strategies for managing recruitment and selection in the Nigerian workplace. This study utilized Resource Based View and Equity Theory in order to build a solid argument for the discourse. Hence, this study concluded that recruiting right calibre of employee in the right position is sine qua non to organizational success. It is recommended that organizations in Nigeria should constantly ensure proper validity of recruitment and selection criteria in-line with global best practices so as to have a round peg in a round hole.
A Narrative Inquiry of Identity Construction in a Post-Colonial Context: Hybrid Identity of a Young Generation Hongkonger
Authors:   Master of Applied Linguistics, The University of Melbourne, Yang Jingmin
Published: August 2021

Identity construction is a complex issue, especially for Hongkongers. Due to historical reason, Hongkongers are regarded to have multiple languages and dual identities, which is hybridity of Chinese (eastern) culture and English (western) culture. Based on the method of narrative inquiry, this study explores how a young generation Hongkonger constructs her identity in a post-colonial context and provides evidence of Hongkonger’s hybrid identity. On the one hand, Hongkongers desire permission to be accepted in the certain cultural communities. On the other hand, they are excluded by both the Chinese community and the English community from a cultural point of view, which leads to localism in Hongkong. As a result, they are like cultural orphans wandering in the cultural “in-between” space.
An Analysis of Identification Theory in Political Fable—A Case Study of Animal Farm
Authors:   School of Foreign Languages, Lanzhou Jiaotong University, Dai Xin
Published: August 2021

Under the guidance of Burke’s identification theory, this paper analyzes the speech of the old Major in the first chapter of Animal Farm from a rhetorical perspective and finds that the old Major persuades his audience, i.e., the other animals, to gain the identification from two aspects: identification by content and identification by form, thus causing the successful uprising of the animals that follows in the storyline. This study explores the embodiment of rhetoric in political fables and analyzes the rationale embedded in the fable from a new perspective, that of rhetoric.
Virtual Reality Language Lab of Second Language Learning Based on J Bruner’s Discovery Learning and Self-Efficacy Theory—Literature Review and Solution Improvement
Authors:   Zhejiang University of Technology, Zhao Zhiyu
Published: August 2021

Language learning has gradually involved innovative technology such as the use of 3D virtual worlds, which can enhance learners’ immersion through improved engagement with the help of their motivational components. Immersion in the target language environment for example English, Spanish, French and German environment provides maximum exposure to the communicative use, offering the opportunity to learners’ active creativity. Since real travel is expensive and impractical, virtual travel in the virtual reality language lab provides them a brand new opportunity. Adopting the literature research method, this paper aims to figure out the optimum time duration and time frequency for most language learners to spend in the virtual world. Based on Discovery Learning and Self-efficacy Theory, we tend to focus on the behaviors of the learner in the virtual world, such as how they express themselves in second language and acquire daily expressions with the help of Unity3D to design and develop 3D virtual worlds and the EEG (electroencephalogram) equipment to reflect changes in the neural representation of the task environment. In order to find a possible relationship between communicative activities and the learning theories of Discovery Learning and Self-efficacy Theory, correlative analysis and principal component analysis were performed. According to this research, we can effectively limit the time and frequency of the immersion in the second language environment and promote the efficiency.
DEVELOPMENT OF COMPOSITION AND PRODUCTION TECHNOLOGIES PAZOPANIB TABLET 400 MG
Authors: ЖУМАКАНОВА А.Е. , ИБРАГИМОВА А.Р. , УСТЕНОВА Г.О.
Published: August 2021

Таргетные методы лечения рака - это лекарства, нацеленные на определенные части раковых клеток, такие как белки или гены, которые способствуют росту и распространению раковых клеток. Трагетная терапия при определенных типах раках является эффективной. При некоторых типах рака таргетная терапия может работать лучше, чем другие методы лечения. От английского target - цель, мишень. Природа таргетных лекарств очень специфична и при разработке они направляются под конкретный мутировавший ген раковой клетки определенного вида опухолевого новообразования. В настоящий момент разными странами разработаны эффективные таргетные препараты для лечения различных генетических форм рака молочной железы, множественной миеломы, лимфомы, рака предстательной железы, меланомы, сарком мягких тканей [1].

Targeted cancer treatments are medicaments that target specific parts of cancer cells, such as proteins or genes that growing power and spread of cancer cells. Targeted therapy for certain types of cancers is effective. For some types of cancer, targeted therapy may work better than other treatments. The nature of targeted drugs is very specific and when developed, they are directed to a specific mutated gene of a cancer cell of a certain type of tumor. Currently, different countries have developed effective targeted drugs for the treatment of various genetic forms of breast cancer, multiple myeloma, lymphoma, prostate cancer, melanoma, soft tissue sarcomas.
SYMPTOMATIC ERYTHROCYTOSIS
Authors: КУЗДЕНБАЕВА Р.С.
Published: August 2021

В статье характеризуются основные виды, причины, ключевые звенья механизмов развития различных форм патологии в системе эритроцитов, их основные проявления и принципы устранения.

The article describes the main types, causes, key links of the mechanisms of various forms of pathology in the erythrocyte system, their main manifestations and the principles of elimination.
THE USE OF ACYCLOVIR, MEDOVIR FOR COMPLEX TREATMENT OF PATIENTS WITH HERPETIC LESIONS OF THE ORAL MUCOSA
Authors: Утепова А.Я. , Досумбекова З.Н.
Published: August 2021

Несвоевременная диагностика и отсутствие рациональной терапии герпетической инфекции приводит к хронической сенсибилизации организма, на что указывает увеличение в крови у этих больных титра антител против в ируса простого герпеса в 5-9 раз.Причиной развития герпетической инфекции является вирус простого герпеса, который после попадания в организм человека может вызывать поражения кожи, глаз, слизистых оболочек, нервной системы, сердечнососудистой системы. Поэтому, как могут быть многоликими проявления герпетической инфекции герпеса.Выводы: После аппликации препаратами эрозивные элементы эпителизировались в течение 4 дней, а в контрольной группе эпителий формировался в течение 8 дней. В течение 3 месяцев под наблюдением у этих больных рецидив заболевания не наблюдался, ИФА была выявлена путем обследования титр Ig G снижен в 2,75 раза.Вместе с тем улучшилось общее состояние больных, сократился и период подписки патологических элементов, удлинился период ремиссии и у больных улучшилось настроение, повысилась жизнелюбие, повысилась мотивация к работе.

Untimely diagnosis and lack of rational treatment of herpes infection leads to chronic sensitization of the body, as indicated by an increase in the blood titer of antibodies against herpes simplex virus in these patients by 5-9 times.The cause of the development of herpetic infection is the herpes simplex virus, which, after entering the human body, can cause damage to the skin, eyes, mucous membranes, nervous system, and cardiovascular system. Therefore, how can there be many manifestations of herpes infection herpes.Results and conclusions: After application with drugs, erosive elements were epithelized for 4 days, and in the control group, epithelium was formed for 8 days.For 3 months of observation, there was no relapse of the disease in these patients, Elisa was detected by examination it was noted that the IG G titer decreased by 2.75 times.At the same time, the general condition of patients has improved, the period of recovery of pathological elements of the USP has also decreased, the period of remission has been extended, and the mood of patients has improved, their enthusiasm for life has increased, and their motivation to work has increased.
OVERVIEW OF THE MARKET OF THE REPUBLIC OF KAZAKHSTAN FOR LIQUID MEDICINAL PRODUCTS WITH EXPECTORANT ACTION
Authors: МУТАЛИМОВА К. , ЖАПАРКУЛОВА К.А.
Published: August 2021

В данной статье приведены актуальности лекарственных препаратов для перорального применения на основе растительных экстрактов, в частности лекарственных растений Чабреца ползучего и Фиалка трехцветной, также обзор Государственного реестра лекарственных средств и медицинских изделий Республики Казахстан по жидким лекарственным препаратам на основе фитосубстанции

This article provides an overview of the relevance of medicinal products for oral use based on plant extracts, in particular medicinal plants Creeping Thyme and Violа tricolor, as well as an overview of the State Register of Medicines and Medical Devices of the Republic of Kazakhstan for liquid medicinal products based on phytosubstance (herbal preparation)
MARKETING ANALYSIS OF RECTAL DRUGS IN KAZAKHSTAN
Authors: ЖЕТПИСБАЕВА А.А. , ДЮСЕМБИНОВА Г.А.
Published: August 2021

В настоящей статье приведены результаты исследований ректальных лекарственных препаратов, представлена общая характеристика ассортимента ректальных лекарственных препаратов, зарегистрированных в Государственном реестре Республики Казахстан. Показаны доли отечественных и зарубежных производителей, количество ректальных лекарственных препаратов, представленных на рынке РК. Выделены лидирующие страны и фармацевтические организации по занимаемой доле рынка ректальных средств в Республике Казахстан. В результате исследований было выявлено, что ректальные препараты отечественного производства составляют 14,3% рынка, а иностранные - 85,7%. Это означает, что большая часть рынка ректальных лекарственных препаратов составляют продукты иностранных производителей.

This article presents the results of research on rectal medicines, provides a general description of the range of rectal medicines registered in the State Register of the Republic of Kazakhstan. The shares of domestic and foreign manufacturers, the number of rectal medicines presented on the market of the Republic of Kazakhstan are shown. The leading countries and pharmaceutical organizations in terms of the occupied market share of rectal drugs in the Republic of Kazakhstan are identied. As a result of research, it was revealed that rectal drugs of domestic production make up 14.3% of the market, and foreign-85.7%. This means that a large part of the market for rectal medicines is made up of products from foreign manufacturers
THE CHEMICAL COMPOSITION OF HELIANTHUS ANNUUS L
Authors: Туреханова А. , Тоштай Қ. , Дуйсебаева М. , Тұрсонжан Т. , Жеңіс Ж.
Published: August 2021

Согласно литературным данным, подсолнечное масло богато полезными веществами, однако, в зависимости от степени очистки масла, количество этих компонентов варьируется. В данном исследовании был изучен дистиллят жирных кислот подсолнечного масла. Согласно полученным данным, более 40% состава кислот приходится на линолевую кислоту с F-витаминной активностью. В большом количестве содержатся стерины, составляющие 44% неомыляемого остатка. Токоферолы составляют 9% неомыляемого остатка, 93% из них приходится на a-токоферол. Helianthus annuus L необходим для приготовления натурального мыла, сочетает в себе способ приготовления медицинского мыла с технологией производства. Экстракт из стебля растения. Это свежее натуральное мыло содержит много полезных микро-и макроэлементов, биологически активные соединения и макро - и микроэлементы растения Helianthus annuus L были определены атомно-эмиссионным методом. Основными из них были K (44,9 мг/г), (377,745 мг/г), Na (3,91 мг/г), (7,56 мг/г) и Mg (3,06 мг/г), (1,495 мг/г). Эти элементы полезны для нашего организма и обладают целебными свойствами. Кроме того, в составе растения H. Annuus L. были определены биологически активные вещества, такие как флавоноиды, алкалоиды, органические кислоты, кумарины и витамины. Эти выявленные данные позволяют получать мыло с высоким качеством, а также целебными свойствами.

Helianthus annuus L salt, which is necessary for the preparation of natural soap, combines the method of preparation of medical soap production technology. The extract from the stem of the plant. This fresh natural soap contains many useful micro and macronutrients, biologically active compounds and macro - and microelements of the plant Helianthus annuus L were determined by atomicemission method. Main of them were K (44.9 mg/g), (377.745 mg/g), Na (3.91 mg/g), (7.56 mg/g) and Mg (3.06 mg/g), (1.495 mg/g). These elements are useful for our body and have healing properties. In addition, biologically active substances such as fiavonoids, alkaloids, organic acids, coumarins, and vitamins were found in the composition of the plant H. annuus L. These identied data allow us to obtain soap with a high composition and quality and healing properties
SCLEROTHERAPY IN PATIENTS WITH HYDROCELE
Authors: КУНЕШОВ Қ.Р. , СЕЙДИНОВ Ш.М. , БАЙТУРСИНОВ Ж.И.
Published: August 2021

В статье представлен обзор мировой литературы о методах лечение больных гидроцеле. Отписываются эволюция и результаты разных методов операции. Особое внимание уделено малоинвазиным методикампункций и склерозированию гидроцеле разными веществами. Полученные результаты показывают минимальную инвазивность и эффективность склеротерапии по сравнению с традиционным хирургическим методом лечения

This article presents the analysis of world literature about methods of treatment hydrocele. The authors describe the evolution and the results of different methods operations of hydrosele. The special attention was paid to miniinvsive methodpuncture and sclerosation of hydrocele with different drugs. The best results were obtained in the treatment of patients operated via sclerosation, than traditional.
MARKETING ANALYSIS OF THE MARKET OF DISINFECTANTS IN THE REPUBLIC OF KAZAKHSTAN
Authors: КАЮПОВА Ф.Е. , КУАНЫШЕВА Д.И.
Published: August 2021

В данной статье представлен анализ рынка дезинфицирующих средств в Республике Казахстан. Определены доли отечественных и зарубежных производителей, количество дезинфицирующих средств, представленных на рынке. Выделены лидирующие страны производители, а также фармацевтические организации в Республике Казахстан. В результате исследований было выявлено, что дезинфицирующие средства отечественного производства составляют 15,52% рынка, иностранные - 84,48%.

This article presents the analysis of the market of disinfectants in the Republic of Kazakhstan. The shares of domestic and foreign manufacturers, the number of disinfectants presented in the market are determined. The leading countries manufacturers, as well as pharmaceutical organizations in the Republic of Kazakhstan are highlighted. As a result of the research, it was found that disinfectants of domestic production account for 15.52% of the market, foreign - 84.48%. Relevance. At the beginning of 2020, the world is facing a pandemic of coronavirus. It is a potentially severe acute respiratory infection [1], which is a dangerous disease that can occur both in mild and severe forms [2]. The virus is transmitted via airborne droplets with the virus sprayed into the air when coughing, sneezing or talking, or by contact with surfaces, followed by infection in the eyes, nose or mouth. The most vulnerable places are public places, transport, markets, etc. The main measure against the spread of infection is compliance with the rules of personal and respiratory hygiene [3]. But, in addition to this, the disinfection of rooms and surfaces should be carried out. The rapid spread of infection has increased the demand for disinfectants. The most important problem is the development of optimal production of domestic products, since the products of other countries occupy a signicant part of the market.Objective: to analyze the market of disinfectants in Kazakhstan.Objectives:- To consider the producing countries;- determine the dynamics of registered disinfectants from 2016 to 2020;- to compare the market value of the most demanded disinfectants;- determine the percentage of dosage forms.Research materials. Register of disinfection, disinsection and deratization means with certificate of state registration in the Republic of Kazakhstan; Register of state registration certicates of the Republic of Kazakhstan.
Denizli İli, Tavas İlçesi, Yaka Mahallesi’ndeki Kilise Kurtarma Kazısı ve Artemis Sibyrallis’e Ait Yeni Bir Yazıtın Ön Değerlendirmesi
Authors: Öztürk Veysel , Yılmaz Fatih
Published: August 2021

Bu makale, 2018-2019 yıllarında Denizli İli, Tavas İlçesi, Yaka Mahallesi, Bağlar Mevkii, Hancı İsmailler Sokak’ta gerçekleştirilen kurtarma kazılarının rapor ve sonuçlarını bilim çevrelerine ve kamuoyuna duyurmayı amaçlamaktadır. İlk etabı tamamlanan disiplinlerarası kurtarma kazıları çerçevesinde bölgenin yerleşim arkeolojisi ve epigrafi araştırmaları öncelikli olarak değerlendirilmiştir. İki açmada sürdürülen kazılar sonucunda neredeyse tamamı devşirme malzemeyle inşa edilen apsisli bir kilise yapısı keşfedilmiş, ancak henüz bir kısmı ortaya çıkarılabilmiştir. Binanın yapımında kullanılan yer döşemeleri, sütun kaideleri, lahitler, seramikler ve Artemis Sibyrallis’in kökenine ait yeni kehanet yazıtı kilisenin daha öncesinde Roma İmparatorluk Dönemi’nde de bir kamu binası olarak kullanım gördüğünü belgelemektedir. Yine de Salbake Dağı’nın hemen kuzeybatı eteklerinde konumlanan söz konusu alan daha önce herhangi bir yerleşimle ilişkilendirilememiştir. Bu nedenle kazı alanının görece olarak yakınında keşfedildiği ileri sürülen Kosa ile Antikosa adlı köylerin söz konusu tanrıçaya adanmasına ve Herakleia Salbake’ye devrine ilişkin daha önceden yayımlanmış bir sınır yazıtı bu çerçevede tekrardan ele alınarak hem kazı alanının bağlamı hem de kentin güney sınırıyla ilintili yeni öneriler sunulmuştur. Tarihsel olaylar çerçevesinde apsisli kilise yapısı da MS 5. yüzyıl sonrasına tarihlendirilerek Herakleia Salbake kentiyle ilişkilendirmiştir.
Atteinte urinaire et pseudo-obstruction intestinale révélatrice d'un lupus érythémateux systémique à propos d'une observation
Authors: Diaby LM , Kane AST , Sanogo A , Maiga AS , Camara Y , Bagayoko DK
Published: August 2021

Introduction : Le lupus érythémateux systémique est une connectivite fréquente chez les femmes en activité génitale.  Au cours du lupus érythémateux systémique, la pseudo-obstruction intestinale est l'une des graves complications rares. Ainsi l'objectif de cet article est de présenter un cas clinique d'atteinte urinaire et pseudo-obstruction intestinale  révélatrice d'un lupus érythémateux systémique. Observation : Une patiente âgée de 28 ans mariée, de Nationalité Guinéenne admise pour une diarrhée fébrile, asthénie, météorisme, associée à des douleurs articulaire et abdominale nécessitant une consultation et des bilans sans succès.Une échographie abdominale qui objective un épaississement diffus de la paroi colique et des anses grêles ainsi qu'une ascite de moyenne abondance. La coloscopie révèle un aspect inflammatoire spécifique de la muqueuse iléale.

Conclusion : La pseudo-obstruction intestinale peut être inaugurale ou concomitante  du lupus érythémateux systémique.
Comorbidité lèpre et tuberculose: à propos de six cas
Authors: Dioussé P , Fall L , Lawson ATD , Diop MM , Diop CT , Dione H , .al Et
Published: August 2021

Objectif : Rapporter 6 observations de co-infection de la lèpre et de la tuberculose. Méthodes : Il s'agissait d'une série rétrospective transversale à visée descriptive réalisée au Centre Hospitalier de l'Ordre de Malte à Dakar (Sénégal) sur une période de 15 ans (2001-2016).Résultats : Six dossiers étaient étudiés.  La moyenne d'âge des patients était de 29 ans ± 10,4 [15 - 42 ans] avec un sex ratio H/F de 2 (4 hommes pour 2 femmes). Quatre patients avaient une lèpre lépromateuse et deux une lèpre borderline (boderline lépromateuse). Le délai médian d'évolution entre la tuberculose et la lèpre était de 32 mois [5 mois- 48 mois]. Les formes de tuberculose retrouvées étaient des formes purement pulmonaires dans 4 cas et multifocale (pleural et ganglionnaire ; pleural puis neurologique) dans 2 cas. Les facteurs de risque de survenue de la tuberculose étaient la corticothérapie générale au long cours, la malnutrition, l'anémie, le tabagisme et la grossesse. La sérologie antirétrovirale à VIH était négative chez tous les patients. Les traitements de la lèpre et de la tuberculose étaient prescrits selon les protocoles de l'OMS. Tous les patients étaient déclarés guéris de la lèpre et de la tuberculose.Conclusion : la survenue de la lèpre dans sa forme multibacillaire sur un terrain immunitaire déficitaire pourrait favoriser soit la réactivation d'une tuberculose latente sous-jacente ou une surinfection de la lèpre par Mycobacterium tuberculosis. Il paraît donc important de rechercher activement la tuberculose durant le screening des patients atteints de lèpre surtout lépromateuse
A ARTE ANATÔMICA E O QUEBRA-CABEÇAS RENASCENTISTA
Authors: Max dos Santos Afonso  , Alan Ávila Fliegel  , Koth André Peres
Published: August 2021

A arte e a anatomia humana caminham juntas, de várias maneiras, ao longo do tempo, como percebemos em diversos desenhos anatômicos, esculturas e afrescos, isto tudo ainda no século XVI, muito por conta das mentes extraordinárias de Leonardo Da Vinci e Michelângelo Buonarotti pois desenvolveram inúmeras criações que são apreciadas até os dias de hoje. Objetivo: apontar um olhar filosófico para as obras A Criação de Adão de Michelângelo Buonarotti e O Homem Vitruviano de Leonardo Da Vinci. Método: Retirando, através de um quebra-cabeças, o ponto-chave destes afrescos com intuito de questionar se, com tal mudança perde-se a sublime beleza ou não há alterações significativas. Conclusão: Embora os conceitos de beleza possam mudar com o tempo, a impressionante falta de “uma peça” muda completamente o significado das obras, mas não diminui a genialidade dos artistas.