bluuebunny/crossref_metadata_2025 huggingface dataset:
3D inversion modelling of gravity data for identification of subsurface structures in the mud volcano area of Sedati, Sidoarjo
Authors: Mariyanto Mariyanto , Lestari Wien , Silitonga Benzamin Ikkian , Tsaniyah Zahrotuts , Agustine Eleonora , Iryanti Mimin , Hapsoro Cahyo Aji , Indriana Rina Dwi
Published: October 2023

Many mud volcanoes are found in Central Java and East Java in the north, but research on mud volcanoes is still limited. This research focuses on the Sedati mud volcano area, Sidoarjo with a research area of 500x400 meters. Measurement of gravity method data with 88 points spaced 50 meters to determine the value of rock density and subsurface structure of Sedati mud volcano area. From the data that has been obtained, data processing is carried out to obtain a map of the distribution of regional and residual gravity anomaly values. From the anomaly data, 3D inversion was carried out to obtain a map of the subsurface structure. The 3D gravity inversion modelling results show that there is high density rock block which is interpreted as a basin that holds the reservoir from the mud volcano. Near the surface and around the mudflow in the study area, the distribution of low density is caused by the presence of mud content. There is a possibility that there is a fault zone with a west-east direction from the study area. The results of the 3D gravity model incision show that the weak zone in the study area is a zone of accumulation of mud which has a density value of 1.8 g/cm3 at a depth of 20 meters to 500 meters.
Thermoelectric conductivity of monolayer FeCl2 under LDA+U
Authors: Prayitno Teguh Budi , Budi Esmar , Nuryasin Bagus , Abdillah Muhammad Andrianto , Kartika Marliana Candra
Published: October 2023

We investigated the influence of Coulomb repulsion via the LDA+U method on the thermoelectric conductivity of monolayer 1T-FeCl2. As the spin-orbit coupling is included, the state transition from metallic state to insulating state appears as the Coulomb repulsion increases, in good agreement with previous results. This is also followed by reduction of thermoelectric conductivity. Nevertheless, the magnetic moment remains unchanged as the Coulomb parameter increases, thus keeping the magnetism in monolayer FeCl2. This indicates that the Coulomb repulsion reduces the thermoelectric conductivity but keeps the magnetism in FeCl2.
Subsurface Structure of Singkarak Pull Apart Inferred from Magnetic and Gravity Modeling
Authors: Amir Harman , Bijaksana Satria , Dahrin Darharta , Nugraha Andri Dian , Arisbaya Ilham
Published: October 2023

The existence of active faults along the Sumatran fault has an impact on tectonic activities such as earthquakes and the formation of pull-apart along the Great Sumatran Fault (GSF). The Great Sumatran Fault is segmented into 19 segments. Fourteen segments of which are pull-apart. One of the pull-apart amongofthe GSF is the Singkarak pull-apart which is located on the Sumani segment. Magnetic and gravitational methods are appropriate geophysical methods used to determine rock structures below the earth’s surface. The subsurface structure of the Singkarak pull-apart analysis needed to identify potential future basins. Based on the analysis of the low magnetic anomaly closures on both sides of Lake Singkarak, this study has also succeeded in identifying the presence of a less dense Quaternary Coluvium volcanic deposition outcrop and concluded that the displacement of about 18± 3 km was resulted from a strike-slip process in the past. Furthermore, Lake Singkarak is estimated to have experienced an opening as far as 8 ±1 km which is based on the maximum width of the model profile that passes through the middle of Lake Singkarak.
The Impact of Microwave Treatment on the Andesite Rock Mechanical Properties
Authors: Heriyadi Bambang , Nata Refky Adi , Tanjung Ardhymanto Am , Fadhilah
Published: October 2023

Alternate rock-breaking techniques to drilling and blasting could include using microwaves to break up rock masses. Drilling for blasting has a significant issue with the cost of drill bit replacement in a short time (weekly). The microwave-breaking technology could be a solution, but research is continuing. This research clarifies the proposed methods through a case study of PT. ATC is an andesite quarry that employs the drill-and-blast technique to break rock. This experiment replicates the previous study’s conclusion that rock strength decreases following microwave treatment on two rock strength tests involving the Point Load Index (PLI) and Schmidt Hammer (SH). The dynamic test (PUNDIT) result indicates that the p-wave velocity of microwaved samples is greater than that of non-microwaved samples (NMW). As a consequence of evaporation and mineral transformation within the rock, the density of the rock decreases, and the porosity increases.
Microstructure analysis of graphene oxide synthesized from corn cobs waste
Authors: Hidayat Rahmat , Ramli Ramli , Sari Istiqomah Wulan , Gusnedi
Published: October 2023

Graphene oxide is one carbon-based material decorated by oxygen functional group that has been applied in various field. Active oxygen functional group allows graphene oxide served as precursor for many applications including DSSC, Field Effect Transistor, LED, and Transparent Conductive Film. Unfortunately, high cost of pure raw material inhibits the wide application of graphene oxide. Corn cobs is one of highly produced waste from agricultural activity that become an unsolved environmental problem. Meanwhile, high content of carbon material in corn cob allows it to be a potential carbon source for graphene oxide synthesis. In this report the synthesis of graphene oxide from corn cobs using modified hummers method is discussed. As synthesized sample was analysed using FTIR, XRD, and SEM to confirm the successful of graphene oxide form corn cobs.
Microtremor analysis around Jari mud volcano, Bojonegoro
Authors: Purba Theresia Romauli , Mariyanto Mariyanto , Komara Eki
Published: October 2023

The earthquake that occurred in the Mount Pandan area in 2016 is thought to have triggered the emergence of a mudflow mixed with water and gas. The research area is in the Kendeng Zone with a complex geological structure. In this zone, there is a very fast sedimentation process so the buried material is not fully compacted. In this study, measurements were made of 6 microtremor data points around Jari Mud Volcano, Bojonegoro, East Java, Indonesia. Furthermore, the data obtained were processed using the HVSR analysis method. HVSR analysis is a method of processing microtremor signals to determine soil characteristics based on information on natural frequency values and its amplification. The result shows the natural frequency parameter and its amplification is slightly variated around Jari Mud Volcano, caused by sedimentary depth variation and/or the presence of existing rock. Based on 6 processed data, the natural frequency values range from 1.9 to 9.1 Hz. Meanwhile, the amplification value ranges from 2.6 to 4.4. Based on the amplification value, the research area is classified as low and medium amplification zones (low value dominance). This is because the amplification value is related to geomorphological conditions, in which the research area is located in the mountains and is composed of volcanic sediments.
Amplification Analysis and Seismic Vulnerability Index of Air Tawar Barat Village of Padang City Using HVSR Method
Authors: Putri Wira Triana , Syafriani  , Fauzi Ahmad , Dwiridal Letmi
Published: October 2023

Padang City is an area that has a very high level of seismic activity in Indonesia. The city of Padang is also an area severely affected by the earthquake in the Subduction Zone. Considerable earthquakes impact building damage and infrastructure, one of the factors that can see the vulnerability of an area with a seismic vulnerability index. Therefore, a study was conducted to determine and analyze the amplification and seismic vulnerability index in the Air Tawar Barat Village of Padang City and create a map of the natural frequency distribution, amplification, and seismic vulnerability index. Microtremor data retrieval was carried out in February-May 2022 using the Seismograph Sysmatrack MAE and S3S Sensors at Air Tawar Barat Village, Padang City. The method used in this study is the HVSR (Horizontal to Vertical Spectral Ratio) method using geopsy software to remove noise in the data and see the natural frequency value and the value of the amplification factor. Furthermore, from the data, contour maps were made using Surfer 13, where the type of research carried out was in the form of descriptive research. Based on the results of the study found that the natural frequency value (f0) in the study area ranged from 0.59141 Hz – 12.9172 Hz, the amplification (A0) ranged from 2.39825 to 13.7759, and the seismic susceptibility index (kg) was 0.4802 – 320.885. Based on the data processing results, it can be concluded that fresh western water is an area with a high seismic vulnerability index, and the location is very vulnerable when shaken by an earthquake.
Analysis of online lectures based on student perspectives during the pandemic.
Authors: Halim A. , Yusrizal  , Saminan
Published: October 2023

In the last two decades the development of information technology (IT) has changed activities, almost all aspects of human life, including the activities of educational aspects. The implementation of conventional face-to-face learning has turned into virtual learning through the internet. There are a large number of students who have experienced both learning systems in college. Therefore, through the research, students were asked to view the types of learning systems that have been carried out online so far. A total of 188 students have been randomly selected from 13 study programs within the Faculty of Teacher Training and Education, Syiah Kuala University and have agreed to become respondents in this survey study. The results of data analysis showed that there was no significant difference between male and female students in assessing online lectures. However, there are several things that are significantly different, including internet network access during online lectures, male students stated that they were quite satisfactory, and female students stated that they were not satisfactory. An important contribution and inference from research results to science learning is getting information about the implementation of online learning and this is an important input for improvement, especially for the development of online modules related to science content.
An investigation on mental representations on coagulation and melting phenomena of preschool pupils with learning disabilities and typical development
Authors: Katsidima Maria-Angeliki , Kaliampos George , Ravanis Konstantinos
Published: October 2023

The aim of the present study is to investigate the mental representations regarding the coagulation and melting phenomena of preschool pupils with learning disabilities. In addition, to compare them with the corresponding representations of typically developing children. By so doing, it aspires to shed light to the feasibility of implementing inclusion into teaching science. To fulfil this purpose, an experimental investigation was conducted with 25 pupils with learning difficulties (M=72.50 months, s.d.=8.11) and 25 pupils with typical development (M=72.50 months, s.d.=9.50). Pupils were selected with convenience sampling while interviews were recorded and transcribed. According to data analysis, pupils’ responses were classified into three distinct levels: sufficient, intermediate and insufficient in terms of school knowledge. Drawing from constructivism theory a digital tool called M.R.H.E.T (Mental Representations Heat Exploration Tool) was developed to fulfill research’s goal. A part of this tool is used for the present study. Findings suggest that preschools pupils with learning difficulties use almost the same ideas on thermal phenomena with those used by preschool pupils with typical development, on a different frequency though. This inevitably reinforces the academic belief of inclusive education for pupils with learning disabilities in teaching science.
The Five-Tier Multiple Choice Instruments in Parabolic Motion for Assessing Concept Understanding of High School Students
Authors: Wijaya Tomi Putra , Mufit Fatni
Published: October 2023

One purpose of physics learning in the 2013 Curriculum was achieved an understanding of the concepts in each physics material. In facts, the teacher had not assessed the students’ concepts understanding, there were no instruments for assessing concept understanding at school and there were misconceptions about the parabolic motion. The solution that can be used to answer this problem was made a five-tier multiple-choice instrument on parabolic motion which was valid and practical to used for assessing concepts uderstanding. This research was development research using the Plomp model which was conducted until the prototype phase. The research began with preliminary research stage. At this stage, giving questionnaires to teachers and a journal analysis was conducted regarding understanding concepts of student on parabolic motion. Then, the research continued with the prototype phase stage was developed five-tier a multiple-choice instrument and determine the validity and practicality of developed product. Based on preliminary research result, it was found that the teacher had not assessed the students’ concepts understanding, there were no instruments for assessing concept understanding at school and there were misconceptions on the parabolic motion. In the development or prototyping phase, produced a five-tier multiple-choice instrument for parabolic motion and conclusions was obtained that the five-tier multiple-choice instrument on parabolic motion was valid and practise to use for assessing the understanding of the concepts of high school students. Therefore, the five-tier multiple choice instrument in parabolic motion can be used in schools for improving students’ concept understanding, especially in parabolic motion.
Validity of guided inquiry-based student worksheets in mechanical waves and thermodynamics
Authors: Sari Silvi Yulia , Sari Mejulia Nurvita , Darvina Yenni , Afrizon Renol
Published: October 2023

21st century learning, especially in learning physics leads to the achievement of Higher Order Thinking Skills (HOTS). These skills can be achieved with various efforts, both the application of learning models and the use of appropriate learning materials. This study aims to develop a valid guided inquiry-based students worksheet as one alternative that can be done to achieve HOTS. The use of this student worksheet can help improve students’ thinking skills through orientation activities, formulating problems, formulating hypotheses, collecting data, testing hypotheses, and formulating conclusions. This research used the ADDIE model. The validation of this student worksheet is in the fourth stage, namely the development stage, which is carried out after the product is created. The results of the validation analysis by experts showed that the guided inquiry-based student worksheets developed were in the very valid category with an average score of 83.1%. This shows that this worksheet has feasibility in terms of presentation, content feasibility, linguistic, and graphic aspects. The results of this validation can contribute as a basis for developing learning materials, especially supporting the optimization of HOTS.
Development of self-diagnostic assessment media by scores based on desktop
Authors: Pribadi F O , Supahar
Published: October 2023

This article was written based on research which aims to develop self-diagnostic assessment media by scores based on desktop on impulse and momentum material. In addition, it aims to determine product quality based on expert assessment and student responses. Product was equipped with the results of the diagnosis and learning suggestions for students based on the scores obtained on each item. The type of research used was the 4-D Model Research and Development. The subjects of this study consisted of 2 experts, 2 practitioners, 3 colleagues, and 44 grade 10 students at Muhammadiyah 2 Yogyakarta High School. Data collection was carried out using product assessment sheets and student response questionnaires. Assessment sheet was used as a guide to the feasibility of the product. The results of expert assessment showed that the products that had been developed were in the “Very Good” category with an average score of 0.90 on a scale of 0-1. Student responses were used as an assessment of product legibility. Student responses showed the “Good” category, with an average score of 3.28 on a scale of 1-4. Therefore, self-diagnostic assessment media by scores based on desktop on impulse and momentum material was appropriate to be used to diagnose students’ initial abilities. In addition, the results of the diagnosis can be used as a basis for evaluation to carry out learning by teachers, so that effective learning can be achieved.
Analysis of Learning Implementation, Skills of 4C, Attitudes Towards Learning and Students’ Understanding Concepts of Physics
Authors: Tanjung M R , Mufit F
Published: October 2023

This research aims to analyze the implementation of learning, skills of 4C, attitudes, and students’ understanding concept of physics at State Senior High School 1 Kinali. The research method used was survey research. The sample in this study amounted to 122 students of eleventh grade major in natural sciences and 3 teachers. In this study, there were four types of instruments, namely a conceptual understanding test (static fluid material), a questionnaire on skills of 4C students, a questionnaire on students’ attitudes towards learning physics, and a questionnaire for teachers in the implementation of physics learning. Data was analyzed using coding and percentage techniques and descriptive analysis. Results was the implementation of physics learning was not fully in accordance with the demands of the curriculum. The results of the test for understanding concept of static fluid material obtained by students who understand the concept were still low (3,6%), and misconceptions by 15.9%. Analysis result of students’ attitudes obtained that students who have a negative attitude of 49,18%. Analysis result of skills of 4C students, it seems that the lowest skills were creative thinking skills as 62,57%. It can be seen from the results of the analysis that there is a discrepancy between the results of the concept understanding test and the students’ self-assessment of their attitude towards learning physics and the 4C skills they have. Therefore, further research is needed such as experimental research to improve the quality of learning by teachers both in the use of learning models, media or material learning.
Analysis of the Coefficient of Performance (COP) on the Car’s Air Cooling System Using a Training Kit with Constant Rotation
Authors: Hidayat Nuzul , Milana  , Yasep Setiawan M. , Giatman M. , Syah Nurhasan
Published: October 2023

The performance of the air condition system is strongly influenced by the compressor work, the condenser cooling temperature. So that the compressor working pressure (suction) and condenser cooling play a very important role in the performance of the air conditioning system which will have an impact on compressor work, compressor power, refrigeration impact, isentropic efficiency and coefficient of performance (COP) of the car air conditioning system. From the research, data will be obtained which include the pressure value on the refrigerant, namely P1 and P2, the temperature on the refrigerant, namely T1, T2, T3 and Tcabin, at the point of installation of the Manifold Gauge and Thermocouple. The research data is then processed and analyzed to obtain performance at constant rotation with variations in compressor working time both actual and theoretical as well as the efficiency of the ac system. From the results of the study, it was found that the compressor rotation was 2300 rpm with a constant rotation then measured the pressure and temperature of the refrigerant, then temperature data was obtained and analyzed to obtain the enthalpy value, thus obtaining the coefficient of performance (COP) of the car air conditioning system. The coefficient of performance (COP) of the resulting system is greater than the actual COP, the optimal COP occurs at P1 30 psi and P2 340 psi working pressures, the actual COP is 3.4848 and the theoretical COP is 4.1500, with an efficiency of 83.97% at 360 seconds.
Development of Internet of Things Based Calorimeter Practicum Tool on Temperature and Heat
Authors: Ramadhanti N. S. , Burhendi F.C.A. , Laksanawati W.D.
Published: October 2023

Measurement errors often occur when students are doing practicum and there is a lack of digital-based tools, especially the use of IoT. The purpose of this research is to develop a calorimeter practicum tool based on the internet of things on temperature & heat materials. This research and development use the ADDIE development model. At the analysis stage, a needs analysis was carried out and the problems encountered. At the design stage, starting with the design of the practicum tool and application. In the development stage, the practicum tools that have been made are tested on material experts, media experts. In the implementation phase, a field test was conducted on a small scale 14 respondents. In the evaluation stage, it is done by analyzed expert validation data, small-scale and large-scale tests. Data obtained from the observation were analyzed descriptively qualitatively. While the validation data were analyzed descriptively qualitatively and quantitatively. The recapitulation score from material experts is 91.8% (very good), media experts are 90.9% (very good), small-scale test is 76.8% (good), large-scale test is 85.08% (very good). So, it can be concluded that the calorimeter practicum tool based on the internet of things is suitable for use in the learning process.
Senior high school students learn physics while playing: how
Authors: Desnita  , Khalid I
Published: October 2023

This research was conducted to improve the quality of physics learning at grade X Science-1 SMAN 1 Padang. Collaboration was conducted between lecturers and physics teachers in the activities of teaching lecturers in schools. The subjects were 35 students of Class X Science-1, which prefer play than study. Their participation and learning outcomes while studying were low. Game-based learning was packed to overcome this problem. Research was conducted for vector addition and straight motion. The research lasted for two circles along eight weeks. The quality of the process was measured by 9 indicators of student activity. The quality of learning outcomes was measured by the proportion of the students who reach the minimum level of completeness. Field notes throughout the learning process showed that all students really enjoy the game and learning. The level of effectiveness of students learning in the first cycle reached 80.32% and classical completeness 91.43%. Level of student activity in the second cycle was 89.21% and classical completeness 88.57%. The quality of the process and learning outcomes in both cycles are very good. These results indicate that the game-based learning can improve the quality of physics learning at Grade X Science-1 of SMAN 1 Padang.
Effect of Generative Learning Models Based on Cognitive Conflict on Students’ Creative Thinking Processes Based on Metacognitive
Authors: Akmam A , Hidayat R , Mufit F , Anshari R , Jalinus N
Published: October 2023

Metacognition is influenced the creative thinking process in Computational Physics courses. The Computational Physics is needed in the business and industrial. However, Computational Physics courses are less attractive for students. The challenge in learning Computational Physics is how to help students effectively develop creative and computational thinking skills. Based on the above, the purpose of this study is to determine the effectiveness of the PGOC3ARE learning model to create the students’ creative thinking skills in Computational Physics learning and to determine the effect of using the PGOC3ARE learning model on metacognitive-based creative thinking skills, especially in Computational Physics courses. The research method used was an explanatory sequential design research method. The research sample was taken through simple random sampling, where the sample was divided into an experimental class and a control class. The sampling technique for collecting qualitative data was purposive sampling. Data analysis using comparative test statistics. The result of the research is that the PGOC3ARE model is effective in shaping students’ creative thinking skills, especially in the Computational Physics course. Furthermore, the PGOC3ARE learning model has a significant positive effect on the development of students’ creative thinking skills in the Computational Physics course with base on metacognition.
Preliminary Study of Development of Chemical Equilibrium E-Module Integrated Virtual Laboratory for High School Students
Authors: Lubis Amalia Putri , Ellizar Ellizar , Zainul Rahadian
Published: October 2023

The use of technology is essential in the twenty-first century, and this includes education. To reduce time and space constraints, educators and students need electronic-based learning materials. E-module is one type of alternate learning medium that can be employed. In order to produce e-modules on chemical equilibrium content, this project will investigate electronic-based learning materials. Since the subject of chemical equilibrium is abstract, students have a hard time grasping its notion. It is anticipated that the use of virtual laboratories and e-modules in chemical equilibrium learning materials will boost students’ competency and independence. To enable students to learn whenever and wherever they are, learning resources in the form of an integrated virtual laboratory e-module are therefore required. Students from SMAN 1 Padangsidimpuan, SMAN 5 Padangsidimpuan, and SMAS Nurul Ilmi Padangsidimpuan made up the research sample for this study, which employed a quantitative descriptive methodology. Needs analysis, idea analysis, and literature review were the three types of analysis used in this study. The methods used to acquire the data were observation, questionnaires, interviews, and relevant document research. The study’s findings point to a variety of issues with the learning process, particularly those that surround the choice of instructional tactics and laboratory experimentation. The findings of this study are anticipated to serve as the foundation for the creation of online modules and attempts to enhance senior high school chemistry instruction.
Improving Digital Pedagogy Competence Through In- Service Training for Elementary School Teacher
Authors: Bentri Alwen , Hidayati Abna
Published: October 2023

Digital pedagogy competencies are needed by teachers in learning in the era of the industrial revolution 4.0. This ability is important for teachers to be able to transform their learning from conventional to digital technology-based. The problem in the field is that many teachers do not have digital pedagogy competencies. This study aims to determine the effectiveness of in-service training for elementary school teachers.This study uses a quantitative experimental method. The research population is elementary school teachers in Sawahlunto City, West Sumatra. Samples were taken purposively as many as 29 teacher representatives from each school. Teachers are given in-service training for 4 meetings. Data were collected from pretest and posttest scores. Data were analyzed using SPSS. The results showed that there was a significant difference between teacher competencies before and after being given training in accordance with the designed digital pedagogy curriculum. In connection with this, it is recommended that teachers need to be given in-service training to improve digital pedagogy competencies so that they can carry out learning optimally in the digital era.The novelty in this research is that the digital pedagogy curriculum that has been implemented can improve teacher competence. The research design in service training allows teachers to be given training with a training system by not leaving their activities as educators who must facilitate students in the classroom. The method used in the training provides convenience for the teacher. In particular, the product of this research can be implemented in schools.
Analysis of the level of student satisfaction with online lectures during the pandemic in terms of gender
Authors: Halim A. , Yusrizal  , Saminan
Published: October 2023

Overall, the implementation of education and learning over the last 5 years has changed towards online learning. Various obstacles and obstacles were encountered in the field, including the unpreparedness of educators and students in using online media. This will lead to dissatisfaction from the implementers, namely students and teachers. This research is focused on analyzing student satisfaction in implementing online learning. The data collection in this study used a survey method and a questionnaire in the form of a google form to 188 students from 12 study programs at the Faculty of Teacher Training and Education, Syiah Kuala University. The results of data analysis showed that there were several statement items that were significantly different between male and female students, including the sensitivity of the lecturer to the level of understanding of students during online lectures. In terms of gender, female students had the highest sense of satisfaction with online implementation. Overall, the results of this study have important contributions and conclusions for science learning, including the level of sensitivity of students in science learning classes should be a major concern by educators during online learning.
Randomizing the trapezoidal rule gives the optimal RMSE rate in Gaussian Sobolev spaces
Authors: Goda Takashi , Kazashi Yoshihito , Suzuki Yuya
Published: October 2023

Randomized quadratures for integrating functions in Sobolev spaces of order

α
≥
1

\alpha \ge 1

, where the integrability condition is with respect to the Gaussian measure, are considered. In this function space, the optimal rate for the worst-case root-mean-squared error (RMSE) is established. Here, optimality is for a general class of quadratures, in which adaptive non-linear algorithms with a possibly varying number of function evaluations are also allowed. The optimal rate is given by showing matching bounds. First, a lower bound on the worst-case RMSE of

O
(

n

−
α
−
1

/

2

)

O(n^{-\alpha -1/2})

is proven, where

n
n

denotes an upper bound on the expected number of function evaluations. It turns out that a suitably randomized trapezoidal rule attains this rate, up to a logarithmic factor. A practical error estimator for this trapezoidal rule is also presented. Numerical results support our theory.
The limit in the (𝑘+2,𝑘)-problem of Brown, Erdős and Sós exists for all 𝑘≥2
Authors: Delcourt Michelle , Postle Luke
Published: October 2023

Let

f

(
r
)

(
n
;
s
,
k
)

f^{(r)}(n;s,k)

be the maximum number of edges of an

r
r

-uniform hypergraph on 

n
n

vertices not containing a subgraph with

k
k

 edges and at most

s
s

 vertices. In 1973, Brown, Erdős and Sós conjectured that the limit

lim

n
→
∞

n

−
2

f

(
3
)

(
n
;
k
+
2
,
k
)

\begin{equation*} \lim _{n\to \infty } n^{-2} f^{(3)}(n;k+2,k) \end{equation*}

exists for all positive integers

k
≥
2

k\ge 2

. They proved this for

k
=
2

k=2

. In 2019, Glock proved this for

k
=
3

k=3

and determined the limit. Quite recently, Glock, Joos, Kim, Kühn, Lichev and Pikhurko proved this for

k
=
4

k=4

and determined the limit; we combine their work with a new reduction to fully resolve the conjecture by proving that indeed the limit exists for all positive integers

k
≥
2

k\ge 2

.
On MaxCut and the Lovász theta function
Authors: Balla Igor , Janzer Oliver , Sudakov Benny
Published: October 2023

In this short note we prove a lower bound for the MaxCut of a graph in terms of the Lovász theta function of its complement. We combine this with known bounds on the Lovász theta function of complements ofHH-free graphs to recover many known results on the MaxCut ofHH-free graphs. In particular, we give a new, very short proof of a conjecture of Alon, Krivelevich and Sudakov about the MaxCut of graphs with no cycles of lengthrr.
Automorphisms and derivations of affine commutative and PI-algebras
Authors: Bezushchak Oksana , Petravchuk Anatoliy , Zelmanov Efim
Published: October 2023

We prove analogs of A. Selberg’s result for finitely generated subgroups ofAut⁡(A)\operatorname {Aut}(A)and of Engel’s theorem for subalgebras ofDer⁡(A)\operatorname {Der}(A)for a finitely generated associative commutative algebraAAover an associative commutative ring. We prove also an analog of the theorem of W. Burnside and I. Schur about local finiteness of torsion subgroups ofAut⁡(A)\operatorname {Aut}(A).
Mutation of the PEBP-like domain of the mitoribosomal MrpL35/mL38 protein results in production of nascent chains with impaired capacity to assemble into OXPHOS complexes
Authors: Box Jodie M. , Anderson Jessica M. , Stuart Rosemary A.
Published: October 2023

Located in the central protuberance region of the mitoribosome and mitospecific mL38 proteins display homology to PEBP (Phosphatidylethanolamine Binding Protein) proteins, a diverse family of proteins reported to bind anionic substrates/ligands and implicated in cellular signaling and differentiation pathways. In this study, we have performed a mutational analysis of the yeast mitoribosomal protein MrpL35/mL38 and demonstrate that mutation of the PEBP-invariant ligand binding residues Asp(D)232 and Arg(R)288 impacted MrpL35/mL38’s ability to support OXPHOS-based growth of the cell. Furthermore, our data indicate these residues exist in a functionally important charged microenvironment, which also includes Asp(D)167 of MrpL35/mL38 and Arg(R)127 of the neighboring Mrp7/bL27m protein. We report that mutation of each of these charged residues resulted in a strong reduction in OXPHOS complex levels that was not attributed to a corresponding inhibition of the mitochondrial translation process. Rather, our findings indicate that a disconnect exists in these mutants between the processes of mitochondrial protein translation and the events required to ensure the competency and/or availability of the newly synthesized proteins to assemble into OXPHOS enzymes. Based on our findings, we postulate that the PEBP-homology domain of MrpL35/mL38, together with its partner Mrp7/bL27m, form a key regulatory region of the mitoribosome.
Examining the role of diversity, equity, and inclusion in mitigating workforce burnout in laboratory medicine
Authors: Mulder Lotte , Garcia Edna , Sirintrapun S Joseph , Kundu Iman , Soles Ryan
Published: October 2023

Objectives

The clinical laboratory workforce plays a crucial role in health care delivery, yet little is known about the unique pressures and challenges this workforce faces. The objective of this study was to identify factors that contribute to burnout, discrimination, exclusion, and inequity in pathology and laboratory medicine.

Methods

A nationwide survey was conducted in 2 phases. In phase 1, 2391 laboratory professionals were surveyed over a 1-week period about their experiences with burnout, discrimination, and work-related stress. In phase 2, the survey was extended to 1 month and questions were added to elicit more detailed information about diversity, equity, and inclusion (DEI) as well as wellness.

Results

Results showed a high prevalence of burnout, discrimination, and stress among laboratory professionals, with significant differences among certain demographic groups. Women, Black, indigenous, or people of color individuals and those with disabilities reported higher rates of discrimination. The study also showed a need for mentorship and resources to address educational barriers.

Conclusions

Findings from this study highlight the urgent need for interventions to address burnout, discrimination, exclusion, and inequity in the laboratory workforce. Initiatives to increase workforce diversity, promote mentorship and diversity training programs, and improve recognition of the laboratory workforce are recommended. The results underscore the pressing need to addressing the challenges and apprehensions laboratory professionals face, including enhancing recognition of their role in patient care, tackling systemic problems related to discrimination and equity, and enhancing the provision of support and resources for managing burnout and fostering well-being.
Management of severe BK viremia in a patient receiving a kidney transplant from a hepatitis C virus–positive donor: A case report
Authors: Gray Megan , Borges Leanna , Conrath Meagan , Marti Kristen
Published: October 2023

Purpose

A case of BK nephropathy in a kidney transplant recipient who received an organ from a hepatitis C virus (HCV)–positive donor is reported.

A 66-year-old male negative for HCV with chronic kidney disease secondary to diabetic glomerulosclerosis received a kidney transplant from an HCV-viremic donor. His initial postoperative course was uncomplicated, and HCV treatment with glecaprevir/pibrentasvir was initiated after discharge. On postoperative day (POD) 60, the patient developed BK viremia and his mycophenolate mofetil dose was decreased. Over the next few months, the BK viral load increased, with mycophenolate mofetil stopped and the tacrolimus goal lowered in response. On POD 130, the patient was admitted for a hypertensive crisis and found to have decreased renal function. During this hospitalization, the patient received a course of intravenous immune globulin (IVIG). Despite an initial response to the modification of immunosuppression therapy and several courses of IVIG over the following months, the patient’s renal function continued to decline. At 18 months after transplantation, the patient was restarted on dialysis and taken off all immunosuppression.

Conclusion

Utilization of organs from HCV-positive donors in HCV-negative recipients allows for expansion of the donor pool and facilitates shorter times on the waitlist. Although initial data in HCV-discordant transplantation did not find an increased risk for opportunistic infections, more recent studies have shown that such risk may be present. This case report describes a patient who developed BK viremia and eventual allograft failure after an HCV-discordant transplantation.
Update on Oblique Flankplasty: Easily Executed, Long-Lasting, Integral Component of Total Body Lift Surgery
Authors: Hurwitz Dennis J , Davila Armando A
Published: October 2023

Background

Twenty years ago, coordinated aesthetic surgery for laxity and lipodystrophy after massive weight loss (MWL), so-called total body lift surgery (TBL), encompassed circumferential hip hugging transverse lower body lift (LBL) with possible buttock auto-augmentation, and a transverse bra line upper body lift (UBL) with breast reshaping. Brachioplasty and vertical thighplasty were often included. Disappointing aesthetics of the posterior torso led to innovation with J-torsoplasty and oblique flankplasty.

Objectives

The goal of this study was to demonstrate in a large clinical series and in a range of case presentations from 2 plastic surgeons that oblique flankplasty with lipoabdominoplasty (OFLA) optimally narrows the waist, suspends lateral buttocks and thighs, and integrates with J-torsoplasty and vertical thighplasty to tighten skin and aesthetically contour the torso and thighs with an acceptable rate of complications.

Methods

Retrospective chart review of 151 consecutive flankplasties between June 2010 and April 2023, including sex, age, BMI, associated operations, complications, and revisions was performed. Five case presentations were accompanied by limited photographs and a marking video.

Results

Across a broad clinical spectrum, malleable oblique flankplasty resected bulging flanks and, facilitated by neighboring liposuction and/or J-torsoplasty, consistently pulled in lax skin and anchored through cadaver-proven dense dermal adherences lax tissues to create a long-lasting skintight shapely torso and upper thighs, with only 3.3% problematic wounds. Five diverse cases showed broad applicability.

Conclusions

OFLA, often with J-torsoplasty and neighboring liposuction, aesthetically recontours torso skin laxity in a variety of presentations with a low rate of complications in a high-risk population.

Level of Evidence: 3
Chemical screening of inhibitors specific for MdDOX-Co that cause an apple columnar tree-shape
Authors: Okamoto Keisuke , Inoue Taiki , Nagano Tsunesato , Miyazaki Sho , Takahashi Ikuo , Asami Tadao , Okada Kazunori , Okada Kazuma , Nakajima Masatoshi
Published: October 2023

MdDOX-Co, the ectopic expression of which is considered to cause the apple columnar tree shape, belongs to the 2-oxoglutarate-dependent dioxygenase (2ODD) family. It adds a hydroxyl group to position 12 of gibberellins (GAs). However, the 2ODD enzymes related to GA biosynthesis and catabolism are phylogenetically distinct from MdDOX-Co. Thus, it is possible that substrates other than GAs exist in MdDOX-Co. To identify the previously unidentified substrate(s) of MdDOX-Co, we searched for MdDOX-Co-specific inhibitors. Chemical screening using gas chromatography-mass spectrometry was performed to investigate the effects of 2400 compounds that inhibited the catalytic reaction of MdDOX-Co, but not the catabolic reaction of GA 2-oxidase, an enzyme involved in GA catabolism. By applying two positive compounds in Arabidopsis, a chemical 3-((2-chloro-6-fluorobenzyl)thio)-5,7-dimethyl-5H-pyrazolo[3,4-e][1,4,2]dithiazine-1,1-dioxide designated as TPDD that did not inhibit GA biosynthesis was selected. The structure-activity relationships among the TPDD analogs were also obtained.
Melanoma incidence and COVID-19 lockdowns in the Netherlands
Authors: Autier Philippe
Published: October 2023

A previous study on nationwide cancer registration in the Netherlands concluded that reduced access to healthcare services during the 930-day long COVID-19 pandemic had a limited influence on melanoma presentation at diagnosis. However, similarly to most publications on the same subject, statistical analyses were restricted to changes in the proportions of melanoma stages at diagnosis and in mean melanoma thickness. We reanalysed the data using incidence rates (IRi). Our reappraisal highlights the way the number of cases of cancer observed during different periods are statistically analysed.
Online psychological support for patients with alopecia areata: an evaluation of available online psychological support material based on the National Centre for Complementary and Integrated Health guidelines
Authors: Lumley Rebecca C , Montgomery Kerry , Asfour Leila
Published: October 2023

Alopecia areata (AA) is an autoimmune condition causing nonscarring hair loss, which is associated with significant psychological comorbidity. We evaluated the range and quality of the online resources available for patients with AA, using the National Centre for Complementary and Integrated Health (NCCIH) criteria. The resources of highest quality were Alopecia UK, National Alopecia Areata Foundation, and Health Talk. The results of this evaluation highlight the importance of signposting patients to specific online resources for psychological support with their condition.
Serum reactivity in dermatitis herpetiformis: an international multicentre study
Authors: Boch Katharina , Heck Florian , Hammers Christoph M , Antiga Emiliano , Caproni Marzia , Juhl David , Goletz Stephanie , Horváth Orsolya N , Huilaja Laura , Khil’chenko Stanislav , Sina Christian , Tasanen Kaisa , Vassileva Snejina , Schlumberger Wolfgang , Zillikens Detlef , Shahid Martin , Drenovska Kossara , Zone John J , Koszorú Kamilla , Fechner Kai , Dähnrich Cornelia , König Inke R , Schmidt Enno
Published: October 2023

Background

Dermatitis herpetiformis (DH) is a rare gluten-induced skin disorder characterized predominantly by IgA autoantibodies against endomysium, tissue transglutaminase (TG2/tTG), epidermal transglutaminase (TG3/eTG) and deamidated gliadin. To date, circulating autoantibody reactivity has not been systematically described.

Objectives

Characterization of serum reactivities in DH.

Methods

This multicentre international study analysed sera from 242 patients with DH taken at the time of initial diagnosis. DH-specific IgA and IgG serum autoantibodies were analysed by indirect immunofluorescence (IF) on monkey oesophagus, and by enzyme-linked immunosorbent assay (ELISA) based on recombinant TG2/tTG, TG3/eTG and deamidated gliadin (GAF3X).

Results

IgA indirect IF microscopy on monkey oesophagus revealed the highest reactivity (84.3%; specificity 100%) followed by IgA TG2/tTG ELISA (78.5%, specificity 99.0%), IgA TG3/eTG ELISA (72.7%, specificity 95.0%) and IgA GAF3X ELISA (69.0%, specificity 98.5%).

Conclusions

Serum IgA and IgG autoantibodies against endomysium, TG2/tTG, TG3/eTG and deamidated gliadin are highly prevalent in DH. Indirect IF microscopy on monkey oesophagus (IgA) provides the highest diagnostic accuracy that can be further enhanced by 4.5% when combined with IgA TG2/tTG ELISA.
AGREE and ESA for Greenness Assessment of a Novel Validated RP-HPLC Method for Simultaneous Determination of Aspirin, Warfarin and Clopidogrel in Rat Plasma: Application to Pharmacokinetic Study of the Possible Interaction between the Three Drugs
Authors: AlSawy Norhan S , ElKady Ehab F , Mostafa Eman A
Published: October 2023

The green profile of the developed method is assessed and compared with previously reported methods. Percutaneous coronary intervention is a procedure where a catheter is utilized to place a stent in order to facilitate opening of the blood vessels in the heart. Triple antithrombotic therapy includes oral anticoagulation as warfarin and dual antiplatelet therapy (composed of aspirin and clopidogrel bisulfate). The aim of the current study was to evaluate the pharmacokinetic parameters of ASP, WAR and CLP and to investigate the possible interaction between the three drugs upon co-administration in rats. A selective and precise RP-HPLC method was developed for the simultaneous determination of ASP, WAR and CLP in rat plasma. Pharmacokinetic study was conducted in rats that received ASP, WAR and CLP as an application of the developed method. From the statistical evaluation of the pharmacokinetic parameters, it was observed that the co-administration of ASP, WAR and CLP significantly increased the ASP and CLP bioavailability in rats. A significant drug–drug interaction was confirmed in the current study. The elevated Cmax of ASP and CLP upon the co-administration of ASP, WAR and CLP may explain the reported bleeding.
Our Parents Were Never Home: Seeing the Pandemic Through Children's Eyes
Authors: Marcelin Giovanni E , Marcelin Nathaniel L , Marcelin Jasmine R , Marcelin Alberto
Published: October 2023

The coronavirus disease 2019 pandemic has taken an unbearable toll on people and families across the globe, with millions dead and hundreds of millions affected in profound ways. In this perspective piece, we center the humanity of the pandemic and its impact on families by telling its story through the eyes of 11-year-old Nathaniel Marcelin and 7-year-old Giovanni Marcelin.