bluuebunny/crossref_metadata_2025 huggingface dataset:
High-risk postoperative opioid prescribing among chronic opioid users with Medicaid insurance v1
Authors: Sharif Limi
Published: September 2022

The objective of this study is to assess the differences in high-risk prescribing among chronic opioid users with Medicaid and commercial insurance. Patients are included if they underwent one of eight procedural categories between November 6, 2017 and February 28, 2021 and had chronic opioid use in the year prior to surgery. The primary exposures of interest are insurance type and presence of a preoperative usual prescriber. Postoperative return to a usual prescriber within 30 days of discharge is also an exposure of interest in the analysis of high risk prescribing in patients who have a preoperative usual prescriber. The primary outcome is new postoperative high-risk prescribing. Secondary outcome is return to a usual prescriber within 30 days. Multivariable logistic regression models will be used to adjust for demographic and clinical differences between study groups.
Time of flight mass cytometry (CyTOF) v1
Authors: Hinderlie Peter
Published: September 2022

Staining procedure for cells analyzed by time of flight mass cytometry.
The Speech Act of Promising in Political Speeches: A Case Study of Obama’s Speeches
Authors: Rakaj Dorinë
Published: September 2022

This study tried to present a pragmatic analysis of the act of promising made by Barack Obama during the presidential campaigns of 2008 and 2012. It utilized a qualitative approach and the data were collected through speeches. However, this study also employed a quantitative method to calculate and present the frequency of promising utterances and performative verbs and their percentages. The researcher used Searle’s taxonomy to analyze Obama’s speeches. The findings showed that assuring, confirming, and reconfirming were the most frequent intentions of the speaker’s speeches during the two election campaigns. Further analysis revealed that Obama used the performative verb ‘‘promise’’ in 7 samples. Moreover, the study showed that the speaker used the modal verb ‘‘will’’ and the form ‘‘be going to + infinitive’’ as ways of promising instead of the performative verb ʻʻpromise.’’ Based on the results of the study, it can be concluded that further studies should be conducted in other contexts to obtain more comprehensive data regarding the act of promising.
Creative Ways of Enhancing Foreign Language Linguistic and Cultural Skills for the Students of Economics
Authors: Zaçellari Manjola Lumani , Beshaj Lediana
Published: September 2022

This study aims to bring to attention the importance of providing creative ideas on how to enhance the foreign language linguistic skills especially for the student of economics, expanding intercultural awareness and knowledge in business and some tailored made exercises which would come to help in this specific study program. Albanian people who speak English are increasing day by day, but most of them show deficiency in their English when it comes to using it in their profession, in regard to their area of expertise. Most of the Albanians learn English at school, then at university level they learn English for specific purpose. Therefore, the universities must make an effort into providing the students with the right textbook (from all the available ones existing in the market), to be used in their tertiary level of studies. This would facilitate the learning process for the students because they will learn and expand their vocabulary in the area they are actually majoring in. Adopting and by making use of the right book, it will enable and promote the use of creative ideas. Technology and multilingualism are ruling over and in the context of a globalized world, specialized languages flourish at an extremely fast pace, and creativity becomes a necessary instrument in the ESP classroom. In Albania, almost all the study programs have English as a mandatory course for the whole academic year and most of the universities offer it in the first and second year of Bachelor level.
Developing EFL Learners' Autonomy in Speaking English: An Investigation Into Teachers’ Support at a University in the Mekong Delta
Authors: Nguyen Cang T. , Nguyen Khanh T. , Pham Huyen N. , Le Diem T. K.
Published: September 2022

Learner autonomy (LA) has been concentrated in the Vietnamese educational context for more than two decades as it equips learners the capacity for lifelong learning. For the EFL tertiary context, students encounter various challenges practicing language skills, especially English speaking, because of lacking the language environment (Huyen & Cang, 2021). As the importance of LA and students’ English speaking skills in language learning, this study aims at exploring what EFL teachers support to develop LA in speaking English. The study using a mix-method approach was conducted at a university in the Mekong Delta with the participation of 12 EFL teachers. To gain insights into teachers’ support to develop LA in speaking English, a questionnaire, recording observations and a semi-structured interview were used to collect data from the participants. The result indicated that the teachers positively supported their learners by offering choices of relevant information belonging to English speaking topics delivered, implementing class discussion and group work activities, encouraging them to self-evaluate and emphasizing the importance of LA in speaking development.
Teacher Identity Construction of Non-Local English-Speaking EFL Teachers in the Intercultural Adaptation Process
Authors: Yi Li , Meng Ling
Published: September 2022

Non-local English-speaking EFL teachers are increasingly employed in the outer or expanding circle of English-speaking countries, but little is known about how these non-local EFL teachers construct their language teacher identity while they go through the intercultural adaptation process. Employing the narrative analysis, this study analysed the data of the in-depth interviews with three non-local English-speaking EFL teachers in one Chinese university and explored their teacher identity construction in the process of intercultural adaptation. Three major types of intercultural challenges were identified in their cross-cultural work in Chinese tertiary education. It was also found that the non-local EFL teachers strategically shift their teacher identities and instrumentalize their non-local identity to adapt to their intercultural teaching work and to empower themselves professionally in the language classes. This study contributes to the understanding of identity making in the intercultural adaptation process and provides implications for the adaptive policymaking and training for non-local teachers.
A Case Study of College Students’ EFL Learning Experiences on Mobile Phone Applications
Authors: Huang Chunbao
Published: September 2022

Mobile English learning (MEL) has become increasingly popular for its diverse advantages especially since the global COVID-19 pandemic. While a lot of studies have confirmed effectiveness of the mobile approach to learning English in a pedagogical context, there is very limited research that focuses on how students’ MEL experiences vary depending on their individual habits and behaviors out of class. This study is aimed to explore college students’ experiences of learning English as a foreign language (EFL) on mobile phone terminals. To this end, the study was conducted with a sample of 359 undergraduate students from 5 different grades by looking into their time spent after class in learning English on mobile phone applications (MPA), their practice preferences in MEL, the number of MPA used and their views on the helpfulness of EFL learning on MPA. The quantitative results derived provide a relatively comprehensive knowledge of the present situation of MEL in a higher education context. Statistically significant findings of the study are hopefully to offer insights for both policymakers and instructors in higher institutions to understand and promote MEL from more scientific and multi-dimensional perspectives.
Competition Between Generation of Nanovoids and Nanocracksin Bimodal Metal-Graphene Composites
Authors:   Institute of Problems of Mechanical Engineering of the Russian Academy of Sciences, Skiba N.V.
Published: September 2022

A theoretical model which describes micromechanisms of the deformation-induced formation of nanovoids and the competition between the nanovoid formation and the deformation-induced formation of nanocracks in bimodal metal-graphene composites is presented. In the framework of the model, the formation of nanovoids and nanocracks occurs at the grain boundary (GB) disclination dipoles near the graphene inclusions. It is demonstrated that the formation of nanovoids at the GB disclination dipoles is energetically favorable process in deformed bimodal Ni-graphene composite.
Lithium Polymer Battery with PVDF-based Electrolyte Doped with Copper Oxide Nanoparticles: Manufacturing Technology and Properties
Authors:   Saint Petersburg National Research University of Information Technologies, Mechanics and Optics, University ITMO, Podlesnov E. , Nigamatdianov M.G. ,   Saint Petersburg National Research University of Information Technologies, Mechanics and Optics, University ITMO, Safronova A.O. ,   Ioffe Institute, Dorogov M.V. ,   Saint Petersburg National Research University of Information Technologies, Mechanics and Optics, University ITMO
Published: September 2022

An overview of electrolyte materials for lithium polymer batteries and the prospects for adding metal oxide nanoparticles to the electrolyte are presented in this paper. A procedure for the synthesis of a gel polymer electrolyte based on polyvinylidene fluoride doped with copper oxide nanoparticles is also described, and the ionic conductivity is measured by the electrochemical impedance spectroscopy. Cells with the synthesized electrolyte and LiFePO4 electrode have been assembled and cycled at different currents. Stable cycling and high capacity have been exhibited by the cell with electrolyte doped with copper oxide nanoparticle (wt. 0.1%).
Constancio Romeo Lasarte (1852-1917), un educador anarquista en Galicia
Authors: Costa Rico Antón
Published: September 2022

A Galiza de finais do século XIX e das primeiras décadas do século XX, intensamente rural e sometida a poderes políticos e relixiosos, foi, tamén, un espazo social e cultural con algunha conflitividade e con dinámicas sociais heterodoxas. E así, hai que falar dos núcleos republicanos, liberal progresistas, de librepensamento e de societarismo obreiro, con presenza non menor da orientación anarquista, que apostaron polo desenvolvemento dunha cultura laica, libre e de emancipación. Neste marco, falamos da figura do educador Constancio Romeo e presentamos un valioso texto seu de educación.
Relembrar e homenagear António de Sena Faria de Vasconcelos (1880- 1939). Insigne pedagogo albicastrense.
Authors: Almeida Vieira Helena Isabel
Published: September 2022

Esta obra coordenada por Ernesto Candeias Martíns surgiu na sequência do Colóquio “Relembrar e Homenagear a obra e a figura do Pedagogo Albicastrense António Sena Faria de Vasconcelos (1880-1939)” realizado em março de 2019, com o intuito de sublinhar a importância cultural e pedagógica desta figura ímpar.
Emoções & Educação. A construção histórica da educação emocional.
Authors: Malheiro Gutiérrez Xosé Manuel
Published: September 2022

Este é um novo trabalho do professor Agustín Escolano, neste caso sobre educação emocional numa perspectiva histórico-educacional e etnográfica. A questão abordada nestas páginas significa uma nova contribuição do autor sobre a história da experiência na educação, uma corrente inovadora de largo alcance, ainda num estado incipiente de proposta e desenvolvimento, que pode afectar o núcleo de conhecimento sobre a construção histórica da cultura escolar centrada no estudo das práticas de formação.
Alteridades e desigualdades nas práticas educativas.
Authors: Vilhena Carla
Published: September 2022

Estamos diante de uma obra que tendo como eixo condutor as questões relacionadas com a alteridade e as desigualdades no campo educativo, nos permite compreender como estas foram pensadas em diferentes espaços geográficos, mas também em diferentes momentos históricos, desde o Brasil Imperial até ao Portugal dos nossos dias.  A obra também nos oferece dados importantes sobre como se foi organizando a escola e a sociedade civil para permitir a educação dos outros, aqueles que se desviam, por diferentes motivos, da imagem dominante de aluno, assim como a relação entre desigualdades sociais, desigualdades geográficas e desigualdades escolares.
Effectiveness of selected Maternal Positions Onbiophysiological Parameters of Antenatal Mothers and Fetus During Non Stress Test
Authors: Hemavathi R. , KalaBarathi S.
Published: September 2022

Non-Stress test is a non-invasive test performed over 28 week of gestation for detection of ante partum fetal surveillance. Maternal positioning can have an impact on both the mother’s and fetal physiological well-being. Objective: Assess and compare the effectiveness of maternal positions on bio physiological parameters of the fetus during NST. Methods: Quantitative quasi-experimental pretest, posttest only research design, 60 mothers were selected by random sampling technique. Maternal, fetal bio physiological parameters tool was used. The mothers were placed in left lateral, supine position while performing NST and fetal parameters were monitored and interpreted. Mother vitals also monitored. Results: The post test score of fetal reaction in supine was 4.20±1.16 and in lateral 4.90±0.31. The calculated independents’ test value of t = 3.205 was found to be statistically significant at p<0.01 level. Conclusion: This reveals that the left lateral position is highly effective position for the mother while performing NST.
Evolution of the cardiac analyzer “Pulse” and the mobile medical devices
Authors: Yavelov I.S. , Danielyan G.L. , Rochagov A.V. , Zholobov A.V.
Published: September 2022

The basis of one of the areas in biomechanics, associated with the development of hemodynamics and fluid mechanics of the heart muscle, has been the use of new fiber-optic sensors, previously developed to solve some engineering problems. In particular, the original sensors of pressure and other physical quantities have been modified for the purpose of measuring cardiac mechanical signals, namely tones, noises and other vibration signals of the heart and pulse pressure waves in the circulatory system. The main idea of introducing such sensors into medicine is formulated as an attempt to enable a general practitioner or a cardiologist, as well as any expert, to quickly collect the necessary data both on the patient’s state of the cardiovascular system and the condition of the entire organism in general. In parallel with designing the sensors, secondary equipment and signal processing algorithms have been developed.
Morphometry of the internal structures of the graylag goose (Anser anser) heart
Authors: Chirkova E.N. , Zavaleeva S.M. , Taiguzin R.Sh. , Sadykova N.N. , Shcheblanova M.A. , Dzhambulatova K.D.
Published: September 2022

As a result of our research, it was found that the heart of the graylag goose Anser anser is a hollow muscular organ weighing 28.950±0.08 g in females (relative 0.73%), 29.091±0.09 (0.69%) in males, with a length: ♀ 51.55±0.07 mm, ♂ 52.66±0.08; it is oval, slightly elongated. Auricular appendices are oval, slightly elongated, in size: the right one with a length ♀14.98±0.05 mm, ♂ 15.57±0.06; with a width ♀ 21.99±0.0 mm, ♂ 22.23±0.05; their wall thickness data are as follows: ♀ 0.47±0.05 mm, ♂ 0.49±0.06; left – ♀ 12.27±0.05 mm, ♂ 12.98±0.06; ♀ 14.89±0.07 mm, ♂ 15.04±0.08; ♀ 0.71±0.03, ♂ 0.78±0.02 mm, respectively; the convex base. The pectineus muscles are located in the walls of the auricular appendices. From the interatrial crest, four to eight pectineal muscles extend, which are connected by smaller muscles, thereby forming a finely looped network. The left ventricle is ♀ 40.97±0.09 mm long, ♂ 41.05±0.08; with a width ♀ 14.89±0.09, ♂ 14.98±0.09; wall thickness ♀ 8.29±0.05, ♂ 8.35±0.07. It contains a tricuspid valve, which has three cusps: septal, caudal, lateral. The right ventricle is ♀ 31.39±0.05 mm long, ♂ 31.49±0.05; with a width ♀ 6.29±0.03, ♂ 6.39±0.05; wall thickness ♀ 2.89±0.03, ♂ 2.91±0.04, has a crescent-shaped atrioventricular opening. The valve length is ♀ 19.17±0.04 mm, ♂ 21.17±0.05 mm.
Severe Asthma and Biologics: Managing Complex Patients
Authors: Matucci A , Micheletto C , Vultaggio A
Published: September 2022

Bronchial asthma is a chronic inflammatory disease of the respiratory tract that varies in terms of clinical presentations (phenotypes) and distinct underlying pathophysiological mechanisms (endotypes). The definition of phenotype/endotype is crucial, given the availability of novel biologic agents for patients who do not respond to conventional therapies. Although patients with type 2 severe asthma benefit significantly from treatment with biologics, nonresponders have been identified. Comorbidities worsen the symptoms of asthma and complicate management of the disease. The assessment and treatment of comorbidities is a crucial step, and appropriate management may improve asthma symptoms and morbidity. Among comorbidities, those with a marked negative impact on control despite appropriate treatment include chronic rhinosinusitis with nasal polyps, obesity, bronchiectasis, and immune deficiency. Although asthma is frequently characterized by increased blood eosinophils that release mediators and cytokines and are involved in inflammation of the airway wall, in patients with very high blood eosinophil levels, we must differentiate between isolated severe eosinophilic asthma and asthma in eosinophilic granulomatosis with polyangiitis. In addition, hypereosinophilia may result from specific biological treatment, as in the case of dupilumab. We outline the clinical features of patients with severe asthma whose disease is complex to manage.
Rancang Bangun Alat Ukur Tribometer Pin-On-Disc Dengan Penggerak Motor Dc Gearbox 12 Volt
Authors: Baharuddin Moh Erwin , Supriyadi Slamet , Burhanudin Aan
Published: September 2022

Tribometer is a tool to determine the occurrence of surface contact wear. The purpose of this research is to design a pin-on-disc tribometer. The design stage involves making a mechanical design, a series of sensors, and designing a complete tool. Tribometer input and output electrical sensor circuit. The software used to program the tribometer is Arduino and uses C++ programming. The pin on disc test stages includes weighing the disc and load variations and setting the disc rotation as desired.
Clinical value of phenylephrine testing in the upper and lower eyelids of patients with aponeurotic and congenital eyelid ptosis
Authors:   Atakoy Dunyagoz Hospital, Bakırkoy, Istanbul 34158, Turkey, Totuk Ozgun Melike Gedar , Kanra Ayse Yagmur ,   Department of Ophthalmology, Sisli Hamidiye Etfal Training and Research Hospital, Sariyer, Istanbul 34453, Turkey, Aykan Umit ,   Etiler Dunyagoz Hospital, Besiktas, Istanbul 34337, Turkey
Published: September 2022

AIM: To characterize the phenylephrine test in aponeurotic and congenital eyelid ptosis, to determine the appropriate timing of the phenylephrine test, and to assess the responses of the upper and lower eyelids.
METHODS: This was a retrospective analysis of 140 eyes of 87 patients (mean age 52.29±16.45y; 22 males, 65 females) with upper eyelid ptosis. Totally 88.6% had aponeurotic and 11.4% had congenital ptosis. For the evaluation of the responses of the upper and lower eyelids to topical 2.5% phenylephrine, the scleral show height, the marginal reflex distance (MRD) between the inferior margin of the upper eyelid and pupillary light reflex (MRD1), and between the central portion of the lower eyelid and pupillary light reflex (MRD2) were measured at the 2nd, 5th, and 15th minutes. The changes of MRD1 and MRD2 with time (ΔMRD1 and ΔMRD2) were evaluated.
RESULTS: The mean MRD1, MRD2, and scleral show heights increased within 5min after testing, remaining largely stable between the 5th-15th minutes. The percentage of eyes with a greater response in MRD1 increased with increased severity of ptosis (P<0.05). Eyes with aponeurotic ptosis were more responsive to phenylephrine testing than congenital ptosis. The mild ptosis group had lower scleral show measurements and higher ΔMRD2 values. The ΔMRD1 and ΔMRD2 values were poorly correlated in all measurement times.
CONCLUSION: Performing the phenylephrine test 5min after instilling the reagent is adequate to assess the maximum response of the upper and lower eyelids. The upper and lower eyelid responses in phenylephrine testing are poorly correlated. However, the ΔMRD2 is related with baseline scleral show degree that may be a postoperative predictive factor. Further studies are necessary to determine the relationship between the responses of the lower eyelids to phenylephrine testing.
Inner limiting membrane peeling prevents secondary epiretinal membrane after vitrectomy for proliferative diabetic retinopathy
Authors:   Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China; National Clinical Research Center for Ocular Diseases, Wenzhou 325027, Zhejiang Province, China, Wu Rong-Han , Lin Ke ,   Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China; National Clinical Research Center for Ocular Diseases, Wenzhou 325027, Zhejiang Province, China, Ren Ming-Xue ,   Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China; National Clinical Research Center for Ocular Diseases, Wenzhou 325027, Zhejiang Province, China, Wen Han ,   Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China; National Clinical Research Center for Ocular Diseases, Wenzhou 325027, Zhejiang Province, China, Feng Ke-Mi ,   Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China; National Clinical Research Center for Ocular Diseases, Wenzhou 325027, Zhejiang Province, China, Zhou Hong-Jia ,   Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China; National Clinical Research Center for Ocular Diseases, Wenzhou 325027, Zhejiang Province, China, Moonasar Nived ,   Caribbean Eye Institute, Valsayn, Trinidad and Tobago, Lin Zhong ,   Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China; National Clinical Research Center for Ocular Diseases, Wenzhou 325027, Zhejiang Province, China
Published: September 2022

AIM: To evaluate the role of internal limiting membrane (ILM) peeling in preventing secondary epiretinal membrane (ERM) formation in pars plana vitrectomy (PPV) for proliferative diabetic retinopathy (PDR).
METHODS: This retrospective study analyzed the medical records of patients who underwent PPV for PDR and were followed up for minimum 3mo. ILM peeling was performed based on the intraoperative surgeons’ judgments. ERM was assessed by optical coherence tomography photography. The relationship between ILM peeling and postoperative ERM was analyzed.
RESULTS: In total, 212 eyes from 197 patients were included in this study. The incidence of secondary ERM in the ILM non-peeling group was significantly higher than that in the ILM peeling group (37.0% vs 14.0%; P<0.001). Multivariate logistical regression revealed that ILM peeling was highly associated with the prevention of secondary ERM development [odds ratio 0.38; 95% confidence interval 0.17-0.86; P<0.05].
CONCLUSION: ILM peeling during PPV for PDRs can effectively reduce the incidence of secondary ERM development and is worth consideration by vitreoretinal surgeons.
Various configuration types of the foveal avascular zone with related factors in normal Chinese adults with or without myopia assessed by swept-source OCT angiography
Authors:   Department of Ophthalmology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, Henan Province, China, Dong Yan-Min , Liu Zhen-Hui ,   Department of Ophthalmology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, Henan Province, China, Fu Shu-Ying ,   Department of Ophthalmology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, Henan Province, China, Wang Ke ,   Department of Ophthalmology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, Henan Province, China, Du Li-Ping ,   Department of Ophthalmology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, Henan Province, China, Jin Xue-Min ,   Department of Ophthalmology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, Henan Province, China
Published: September 2022

AIM: To describe the morphological characteristics of foveal avascular zone (FAZ) in normal Chinese adults with or without myopia by swept-source optical coherence tomography angiography (SS-OCTA) and analyze the possible associated factors.
METHODS: Normal Chinese adults with or without myopia aged between 18 and 60y were recruited into the study. One eye in each individual was randomly selected for scanning using SS-OCTA. FAZ parameters, central retinal thickness (CRT) and central choroidal thickness (CCT) were then analyzed. Correlations between systemic and ocular variables and FAZ parameters were subsequently evaluated. The subgroup analysis based on refractive error was also carried out.
RESULTS: In total, 127 eyes out of 127 normal subjects were finally included in the study (mean age 29.5±8.22y, 61 males and 66 females). The pattern of FAZ was variable: round configuration in 28 eyes (22%), quadrilateral configuration in 23 eyes (18%), pentagonal configuration in 20 eyes (16%), oval configuration in 15 eyes (12%), triangular configuration in 6 eyes (5%) and irregular configuration in 35 eyes (28%). The mean area of FAZ was 0.37±0.12 mm2. Females had a larger FAZ (0.41±0.11 mm2 vs 0.32±0.11 mm2) compared with that of males (P<0.01). All myopic individuals showed smaller FAZ area and perimeter compared with that of normal individuals (P<0.01). There was no obvious correlation between age and FAZ. In the univariate regression analysis, both axial length (AL) and refractive error were significantly related to FAZ parameters. However, only CRT showed negative correlation with FAZ in the multivariate regression analysis.
CONCLUSION: The pattern of FAZ configuration in normal Chinese adults with or without myopia is highly variable. Establishing quantitative parameters of FAZ would not only provide details of macular pathophysiology but could possibly contribute as a biomarker in disease staging.
Efficacy and safety of intravitreal HLX04-O, an anti-VEGF monoclonal antibody, for the treatment of wet age-related macular degeneration
Authors:   Department of Ophthalmology, Xuzhou Central Hospital, Xuzhou 221009, Jiangsu Province, China, Zhang Zhen , Lyu Ya-Li ,   Shanghai Henlius Biotech, Inc., Shanghai 200233, China, Chang Meng-Qi ,   Department of Phase 1 Clinical Trial, Xuzhou Central Hospital, Xuzhou 221009, Jiangsu Province, China, Xu Qiu-Jin ,   Department of Phase 1 Clinical Trial, Xuzhou Central Hospital, Xuzhou 221009, Jiangsu Province, China, Liu Yi-Ming ,   Shanghai Henlius Biotech, Inc., Shanghai 200233, China, Kang Wen-Ying ,   Shanghai Henlius Biotech, Inc., Shanghai 200233, China, Wang Qing-Yu ,   Shanghai Henlius Biotech, Inc., Shanghai 200233, China, Li Chuan-Ling ,   Department of Phase 1 Clinical Trial, Xuzhou Central Hospital, Xuzhou 221009, Jiangsu Province, China
Published: September 2022

AIM: To evaluate the efficacy and safety of HLX04-O, an investigational ophthalmic formulation of HLX04 (bevacizumab biosimilar) for intravitreal injection, as a treatment for wet age-related macular degeneration (wAMD) in a phase 1/2 clinical trial (NCT04993352).
METHODS: Eligible patients with wAMD were enrolled to receive HLX04-O intravitreal injections at a dose of 1.25 mg/0.05 mL every four weeks. Efficacy and adverse events were evaluated every month during study visits.
RESULTS: A 76-year-old male with wAMD in his left eye participated in the trial and completed six cycles of HLX04-O intravitreal injections. Changes were observed in macular center point thickness (baseline vs last study visit, 437 vs 255 μm) and best-corrected visual acuity letter score (baseline vs last study visit, 36 vs 77) of the affected eye, which indicated an improvement in wAMD over treatment. No adverse events were reported by the data cutoff date.
CONCLUSION: HLX04-O at 1.25 mg/0.05 mL every four weeks is well tolerated in this patient, demonstrating promising safety and efficacy in wAMD treatment. Large-scale studies are required to confirm the outcomes.
Percepção materna sobre aleitamento: importância e fatores que influenciam o desmame precoce
Authors: Dos Santos Nadja Nadynne Beserra , Souza Aloiso Sampaio , Candido Paula Gabrielle Gomes , Fontoura Guilherme Martins Gomes , Lobato Jaisane Santos Melo , Oliveira Iraciane Rodrigues Nascimento
Published: September 2022

Introdução: O desmame precoce configura como problema de saúde pública, relacionado a vários fatores, como idade materna, baixo nível de escolaridade, uso precoce de fórmulas lácteas e chupetas, trabalho materno, entre outras. Objetivo: Identificar a percepção das mães de crianças menores de 2 anos acerca da importância do aleitamento materno, bem como analisar as principais alegações que as levaram ao desmame precoce. Métodos: Trata-se de uma pesquisa do tipo descritiva, de natureza transversal e com abordagem quantitativa, realizada em Unidades Básicas de Saúde do município de Governador Edison Lobão-MA. A pesquisa deu-se através de um questionário de questões objetivas afim de analisar o perfil sociodemográfico e econômico das participantes. Resultados: Participaram da pesquisa 51 mulheres, com idade média de 20,9 anos de idade. Foi constatada maioria de mães solteiras, primíparas, donas de casa e com realização das consultas de pré-natal periodicamente. Foi encontrado, na região, um índice de desmame precoce de 64,7%. Conclusões: Crenças quanto ao leite materno ser insuficiente para o bebê e a introdução de novos alimentos estão entre as causas encontradas para o desmame precoce.  Evidencia-se a importância da implementação de estratégias que visem a adesão, a promoção, e o aumento da prevalência do aleitamento materno exclusivo.
Perfil de gestantes em hospital público na grande São Paulo
Authors: Souza Paula Cristina Meirelles de , Santos Juliana Leandro Silva , Chimello Marianne De Faria , Martins Danielle Pereira , Kutz Nyvian Alexandre , Oliveira Narcisio Rios , Salgueiro Marcia Maria Hernandes de Abreu de Oliveira
Published: September 2022

Objetivo: Avaliar o perfil de gestantes atendidas em uma maternidade pública na grande São Paulo.Materiais e métodos: Estudo transversal com amostra por conveniência, que avaliou variáveis sociodemográficas, do consumo alimentar e do estilo de vida coletadas por meio de questionário estruturado e informações sobre o pré-natal coletadas do cartão de pré-natal e no prontuário da paciente. Resultados: Participaram 186 puérperas com média de idade de 27,7 ± 5,8 anos, 70% tinham até 12 anos de escolaridade, 77% pertenciam à classe socioeconômica C e 60% exibiam excesso de peso no período pré-natal. Quanto ao consumo alimentar, 79% classificaram-se em “atenção” e 90% mostraram estilo de vida desfavorável. 71% realizaram seis ou mais consultas de pré-natal.Conclusão: A maioria apresentou consumo alimentar e estilo de vida inadequados, alta prevalência de excesso de peso pré-gestacional, 12 anos de escolaridade e classe socioeconômica C. Aquelas com maior escore no consumo alimentar apresentaram estilo de vida favorável.
Constructing the Mate of Cospectral 5-regular Graphs with and without a Perfect Matching
Authors: Solomko Viktoriia , Sobolev Vladyslav
Published: September 2022

The problem of finding a perfect matching in an arbitrary simple graph is well known and popular in graph theory. It is used in various fields, such as chemistry, combinatorics, game theory etc. The matching of M in a simple graph G is a set of pairwise nonadjacent edges, ie, those that do not have common vertices. Matching is called perfect if it covers all vertices of the graph, ie each of the vertices of the graph is incidental to exactly one of the edges. By Koenig's theorem, regular bipartite graphs of positive degree always have perfect matching. However, graphs that are not bipartite need further research.

Another interesting problem of graph theory is the search for pairwise nonisomorphic cospectral graphs. In addition, it is interesting to find cospectral graphs that have additional properties. For example, finding cospectral graphs with and without a perfect matching.

The fact that for each there is a pair of cospectral connected k-regular graphs with and without a perfect matching had been investigated by Blazsik, Cummings and Haemers. The pair of cospectral connected 5-regular graphs with and without a perfect matching is constructed by using Godsil-McKay switching in the paper.
Toward an Institutional Analytics Agenda for Addressing Student Dropout in Higher Education
Authors: De Silva Liyanachchi Mahesha Harshani , Chounta Irene-Angelica , Rodríguez-Triana María Jesús , Roa Eric Roldan , Gramberg Anna , Valk Aune
Published: September 2022

Although the number of students in higher education institutions (HEIs) has increased over the past two decades, it is far from assured that all students will gain an academic degree. To that end, institutional analytics (IA) can offer insights to support strategic planning with the aim of reducing dropout and therefore of minimizing its negative impact (e.g., on students, academic stakeholders, and institutions). However, it is not clear how institutional stakeholders can integrate IA in their practice to overcome academic-related issues and to offer support to students who struggle to achieve their academic goals. To address this gap, we conducted focus groups with 13 institutional stakeholders of an Estonian university. By analyzing the focus group data, we identified three main categories of factors influencing dropout from the perspective of institutional stakeholders: (1) institutional experience, (2) educational goals, and (3) personal aspects. We discuss our findings from an institutional perspective with the aim of reflecting on institutional processes, organizational structures, and facilitatory roles in the context of dropout in higher education (HE). We argue that IA can provide insights into students’ institutional experience, educational goals, and personal aspects to further support decision-making on the institutional level. We envision our findings contributing to a participatory agenda for the design, implementation, and integration of IA solutions focusing on addressing dropout in HE.
Design Analytics for Mobile Learning
Authors: Pishtari Gerti , Prieto Luis P. , Rodríguez-Triana María Jesús , Martinez-Maldonado Roberto
Published: September 2022

This research was triggered by the identified need in literature for large-scale studies about the kinds of designs that teachers create for mobile learning (m-learning). These studies require analyses of large datasets of learning designs. The common approach followed by researchers when analyzing designs has been to manually classify them following high-level pedagogically guided coding strategies, which demands extensive work. Therefore, the first goal of this paper is to explore the use of supervised machine learning (SML) to automatically classify the textual content of m-learning designs using pedagogically relevant classifications, such as the cognitive level demanded by students to carry out specific designed tasks, the phases of inquiry learning represented in the designs, or the role that the situated environment has in the designs. Because not all SML models are transparent, but researchers often need to understand their behaviour, the second goal of this paper is to consider the trade-off between models’ performance and interpretability in the context of design analytics for m-learning. To achieve these goals, we compiled a dataset of designs deployed using two tools, Avastusrada and Smartzoos. With this dataset, we trained and compared different models and feature extraction techniques. We further optimized and compared the best performing and most interpretable algorithms (EstBERT and Logistic Regression) to consider the second goal with an illustrative case. We found that SML can reliably classify designs with accuracy > 0.86 and Cohen’s kappa > 0.69.
Investigating Cases by Undercover or Real Identity Investigators and Collaborators
Authors: Barbu Denisa
Published: September 2022

"Evidence is the main nerve of the criminal process. They shed light on nebulous issues in the criminal process'', said professor Ioan Tanoviceanu (1913; Boţic, 2016, p. 132). Today, the notion has kept the same metaphorical meaning, as the entire activity of judicial bodies is based on the notion of evidence. The activity of the judicial bodies starts from the moment of initiation of the criminal process. The existence of the criminal process, seen as a report of criminal procedural law, is in turn conditioned by the birth of the legal report of substantive criminal law (Florea et al., 2019; Florea & Galeş, 2020). As is known, the material criminal conflictual report arises from the violation of substantive law norms, or more simply from the commission of a crime (Damian et al., 2021). The purpose of the entire activity of the judicial bodies, especially in the criminal prosecution phase, is to reconstruct the criminal course of action (iter criminis) and to decide on the merits of the case as a result of the administration of the evidence obtained legally and in good faith (Apostu, 2016; Apostu & Petrescu, 2017). Only in such conditions can the "satisfaction" of fairness be offered, which increases the confidence of litigants in the justice system and finally in the educational role of the criminal process (Mateuţ, 2019, p. 28).
Klinik biyokimya laboratuvarlarında kullanılan panik değerleri kronik myeloproliferatif neoplazilerin tanısında kullanılan ölçütlere göre gözden geçirilmeli midir?
Authors: ARDICOGLU AKIŞIN Yasemın , BEYAN Cengiz
Published: September 2022

Amaç: Panik değerler, laboratuvar test sonuçlarının acil müdahale edilemediği takdirde hastanın hayati tehlikesi olabileceğini işaret eden sınır değerlerdir. Her tıbbi laboratuvar panik değerlerini her test ve durum için ilgili klinik ile beraber saptamalıdır ve bildirimlerini zamanında yaparak dokümante etmelidir. Polisitemia vera, esansiyel trombositemi, primer myelofibrozis ve kronik myelositer lösemi gibi malign hastalıkları içeren kronik myeloproliferatif neoplaziler (MPN) , hematopoietik dokunun, malign ve klonal bir hastalığıdır. Dünya Sağlık Örgütü (DSÖ) 2016 yılında hematopoetik ve lenfoid doku tümörlerinin sınıflamasında güncelleme yapmıştır. Bu çalışmadaki amaç laboratuvarımızdan yapılmış panik değer bildirimleri ile yeni DSÖ ölçütlerine göre belirlenmiş kronik MPN sınır değerlerinin üzerinde çıkan test sayılarını karşılaştırmaktır.

Gereç ve Yöntemler: Çalışmada 15 yaş üzeri 58223 hastaya ait tam kan sayımı sonucu değerlendirmeye alınmıştır. Elde edilen hemoglobin, hematokrit, trombosit ve lökosit sayısı panik değer bildirim sayı veya yüzdeleri laboratuvarımızın panik değerlerine ve kronik MPN için DSÖ kriterlerine göre değerlendirilmiş ve karşılaştırılmıştır.

Bulgular: Kemik iliği incelemesi yapılması için uyarıcı olması gereken hemoglobin düzeyleri için mevcut panik değer sınırlarının kullanılması halinde kadınlarda %1,13, erkeklerde %8,90; hematokrit düzeyleri için kadınlarda yaklaşık %9,59, erkeklerde %8,52 oranında hasta gözden kaçarak kronik MPN yönünden takibe alınamamaktadır. Kemik iliği incelemesi olmaksızın kronik MPN lehine uyarıcı kabul edilmesi gereken oranlar hemoglobin için kadınlarda %0,68, erkeklerde %1,74; hematokrit için kadınlarda %0,94, erkeklerde %0,38’dir. Trombosit sayısı için bu oran %2,20 iken, lökosit sayısı için %24,78’dir.

Sonuçlar: Çalışmamızın sonuçları kronik MPN açısında uyarıcı olabilmesi için panik değerlerin 2016 DSÖ kılavuzundaki kronik MPN kriterlerine göre gözden geçirilerek yeniden düzenlenmesi gerekliliğini doğurmuştur.
Biological control perspectives in the pine forest (Pinus spp.), an environmentally friendly alternative to the use of pesticides
Authors: Gutiérrez-Flores Luis Martín , López-Reyes Lucía , Hipólito-Romero Enrique , Torres-Ramírez Eduardo , Castañeda-Roldán Elsa Iracena , Mauricio-Gutiérrez Amparo
Published: September 2022

Forests are important for their economic, ecological, and social contribution to humanity. However, there is a decrease in the forest mass due to different causes such as fire, intensive agriculture, overgrazing, air pollution, and the presence of pests and diseases of fungal origin. A practice to deal with diseases caused by fungi has been the application of broad-spectrum, fungicides with negative consequences on the environment. Biological control is an alternative for disease management in pine species. Due to the need to conserve the diversity of pine species, this review addresses issues relevant to the importance of forests in the world, diseases in Pinus spp., fungal control by chemical and biological agents, referring to different biological control mechanisms and the most studied biofungicides such as Trichoderma sp. and Bacillus sp. in Pinus spp. The various scientific reports on the biological control of fungi in different pine species places it as a promising option in reducing the pathogenicity and incidence of fungal diseases with less negative effects on the environment than synthetic pesticides of chemical origin. Therefore, this review aims to transmit information on biological control in pine trees as a friendly alternative for the recovery of forests.
Preliminary identification and phylogenetic relationships of begomoviruses associated with Capsicum spp. in the Yucatan peninsula, Mexico
Authors: Gracia-Medrano Rosa María Escobedo , Maldonado-Borges Josefina I. , Sánchez-Cach Lucila A. , Minero-García Yereni , Hernández-Zepeda Cecilia , Moreno-Valenzuela Oscar A.
Published: September 2022

Pepper plants with viral symptoms were collected in the Yucatan Peninsula, Mexico (YPM) with the objective to characterize the partial identity and the genetic and phylogenetic relationship of the begomoviruses infecting different pepper species, including Capsicum chinense, various C. annuum landraces, C. frutescens, C. a. var. aviculare, as well as some weeds. The leaf samples were collected during two severe whitefly infestation seasons. Total genomic DNA from the sampled plants was extracted and a fragment of the begomoviruses was amplified using universal primers. Amplicons obtained were sequenced and sequences were used for genetic and phylogenetic analysis. Our results demonstrate that 90.1 % of the total sampled plants (151) were infected with begomoviruses. The data identified Pepper golden mosaic virus (PepGMV) as the most frequent species found within cultivated, semi-cultivated, and wild-analyzed samples. In addition, sequence analysis indicates the presence of Euphorbia mosaic virus-Yucatán Peninsula (EuMV-YP) infecting a Habanero chili plant, as well as the predominance of PepGMV in different weed plant species. Genetic variation based on nucleotide distance analysis from partial DNA-A begomovirus sequences indicated that the PepGMV isolates were closely related among them sharing 95 to 99% nucleotide sequence identity. Data showed that begomovirus that infected the sampled plants included the partially identified species of PepGMV, Pepper huasteco yellow vein virus (PHYVV), Tomato severe leaf curl virus (ToSLCV), Tomato yellow leaf curl virus (TYLCV) and EuMV-YP.
Perforations Tympaniques: Aspects Epidemiologiques en Orl au Centre Hospitalies Sylvanus Olympio de Lome au Togo
Authors: Winga Foma , Essobiziou Amana , Hervey Reoulembaye Djim , Gérémie Ananidjin , Uziel Boko , Bathokédéou Amana , Essobozou Pegbessou , Essohanam Boko
Published: September 2022

Objectif : décrire les aspects épidémiologiques et étiologiques des perforations tympaniques. Patients et Méthode: Il s’est agi d’une étude rétrospective descriptive des perforations de la membrane tympanique au service d’ORL du centre hospitalier universitaire Sylvanus Olympio de Lomé allant du 1er Janvier 2021 au 31 Mai 2022. Etaient inclus tous les dossiers des patients dont la plainte ou l’une des plaintes se rapportait à l’oreille, avec entre autres, une perforation tympanique à l’examen otoscopique. Les données ont été traitées et analysées par le logiciel SPSS 28.0 et Excel. Résultats : au total, 153 dossiers ont répondu aux critères d’étude. L’âge moyen des patients était de 29 ans avec des extrêmes de 9 mois et 83 ans. Le sexe masculin était retrouvé dans 79 cas avec un sex-ratio H/F de 1,1. Les patients exerçant une fonction libérale étaient retrouvés dans 34% des cas. Le motif de consultation était une otorrhée purulente dans 40,5% des cas. L’otoscopie avait montré une perforation unilatérale dans 83,7% des cas dont 43,8% des cas à droite. Cette perforation était non marginale dans 79,1% des cas et non ponctiforme dans 56,9% des cas. Les perforations étaient dues à l’otite moyenne aigue dans 51% des cas, à l’otite moyenne chronique suppurée simple dans 24,2% des cas et aux traumatismes dans 22,8% des cas. Conclusion: la perforation tympanique est souvent due à l’otite moyenne aigue chez les patients jeunes.
Evaluation de L’impact de L’entrepreneuriat sur la Croissance Economique au Cameroun : Une Analyse Econometrique
Authors: Boris Dudjo Yen Gildas , Roméal Eboue , Oliver Ewondo Mbebi
Published: September 2022

L’objectif de cette présente étude est d’évaluer l’impact de l’entrepreneuriat sur la croissance économique au Cameroun sur la période de 2005 à 2020. L’entrepreneuriat est au cœur des politiques de développement. Les gouvernements se trouvent toutefois confrontés à un défi nouveau, car favoriser l’entreprenariat en tant qu’institution socioéconomique est une démarche qui diffère très sensiblement de celle à adopter pour concevoir et mettre en œuvre d’autres mesures de politique économique. Portant, pour dynamiser la création d’entreprise, le gouvernement Camerounais a élaboré des programmes et politiques afin encourager davantage l’activité entrepreneuriale pour une économie qui se veut émergente. Nous avons appliqué la méthode d’estimation ARDL (Autoregressive Distributed Lag). En plus, les résultats montrent qu’à court terme, l’impact de l’entrepreneuriat sur la croissance est positif et significatif. A long terme, nous constatons un résultat similaire car l’entrepreneuriat exerce un effet positif et significatif. Ces résultats sous-entendent que les pouvoirs publics doivent davantage mettre un accent sur la création des start-ups.
Enhancing China–Africa Cooperation in the Renewable Energy Sector
Authors: Ayele Seife , Shen Wei , Chiyemura Frangton , Gu Jing
Published: September 2022

Access to affordable and sustainable electricity is of fundamental importance to development in much of Africa. But, while access to electricity is improving, contributions from non-hydropower renewable energy sources remain small. At the same time, China – the powerhouse of solar energy technologies – has made limited contribution to harnessing Africa’s renewable energy. Combining insights from recent webinars and research, this Policy Briefing discusses how China–Africa cooperation on renewable energy could lead to improvements in access to and supply of affordable and sustainable energy in Africa. Recommendations for African and Chinese policymakers and businesses include the adoption of transparent, competitive, and locally inclusive energy procurement and use mechanisms.