bluuebunny/crossref_metadata_2025 huggingface dataset:
Occurrence of vocal changes in preschoolers with no voice complaints: an auditory-perceptual and acoustic analysis
Authors: Nascimento Gabriela Samanttha Cavalcanti do , Nascimento Giselle Frutuoso do , Silva Juliana Fernanda Dias da , Lima Sandro Júnior Henrique , Lira Zulina Souza de , Gomes Adriana de Oliveira Camargo
Published: February 2021

ABSTRACT Purpose: to verify, with the auditory-perceptual and acoustic parameters, the occurrence of voice changes in children with no voice complaints, per sex. Methods: the registers of 36 children with no voice complaints, aged 6 to 8 years, of whom 19 were males, were assessed. The databank consisted of the recordings of sustained vowels, sentences, and spontaneous speech. The auditory-perceptual analysis was conducted with the Consensus Auditory-Perceptual Evaluation of Voice, and the acoustic analysis, with VoxMetria. The fundamental frequency, jitter, shimmer, noise, and glottal-to-noise excitation ratio were analyzed. The Mann-Whitney test was applied for numerical variables, and the McNemar test, for the categorical ones, at the p < 0.05 significance level. Results: of the 5 children with mild voice changes, 4 were males. The most frequent resonance deviation was the laryngopharyngeal one. There was no difference between the sexes in the auditory-perceptual findings. The fundamental frequency in the group with changes was lower than that in the group without changes. There was a statistical association between the changes in the auditory-perceptual assessment and the acoustic parameters. Conclusion: voice changes occurred in 13.89% of the studied sample of children with no voice complaints, without differences between the sexes in the auditory-perceptual parameters. Vocal deviations were in a mild degree in all children who had them, the most frequent ones being roughness and breathiness. The fundamental frequency and shimmer were the acoustic parameters whose values most often occurred outside the reference limits, in both genders.
Sociodemographic profile and stages of Parkinson’s disease associated with predictors of Temporomandibular Disorder
Authors: Oliveira Jonatas Silva de , Sobral Amanda do Vale , Silva Taysa Vannoska de Almeida , Coriolano Maria das Graças Wanderley de Sales , Lins Carla Cabral dos Santos Accioly
Published: February 2021

ABSTRACT Purpose: to analyze the predictors of temporomandibular disorder in people with Parkinson’s disease, verifying their associations with sociodemographic aspects and stages of the disease. Methods: a study based on secondary data from research conducted in 2017 with 110 people with Parkinson’s disease. They were assessed with the Research Diagnostic Criteria for Temporomandibular Disorders and the Parkinson’s disease staging scale. The studied predictive variables for temporomandibular disorder were pain, crepitation, clicking, nighttime and daytime clenching/gnashing, uncomfortable/non-habitual bite, morning rigidity, and tinnitus. The sociodemographic aspects assessed were age, sex, schooling level, marital status, income, and stages 1 to 3 of the disease. The chi-squared odds ratio was used with a 95% confidence interval and significance level at p < 0.05. Results: an association was verified between nighttime clenching/gnashing and income (p = 0.006); tinnitus and income range from ½ to 3 (p = 0.003) and from 4 to 10 minimum wages (p = 0.004); and between tinnitus and stage 1 (p = 0.02). Conclusion: this study verified that the predictors associated with temporomandibular disorder in people with Parkinson’s disease were pain, clicking, crepitation, uncomfortable/non-habitual bite, and morning rigidity. It was verified that income and stage 1 of the disease had an association with nighttime clenching/gnashing and tinnitus.
ANTHROPOMETRIC AND DIETARY ASSESSMENT OF PATIENTS WITH GLYCOGENOSIS TYPE I
Authors: Jorge Natália Bauab , Tommaso Adriana Maria Alves de , Hessel Gabriel
Published: February 2021

ABSTRACT Objective: To perform anthropometric and dietary evaluation of patients with glycogenosis type Ia and Ib. Methods: This cross-sectional study is composed of a sample of 11 patients with glycogenosis divided into two subgroups according to the classification of glycogenosis (type Ia=5 and type Ib=6), aged between 4 and 20 years. The analyzed anthropometric variables were weight, height, body mass index, and measures of lean and fat body mass, which were compared with reference values. For dietary assessment, a food frequency questionnaire was used to calculate energy and macronutrients intake as well as the amount of raw cornstarch consumed. Mann-Whitney U test and Fisher’s exact test were performed, considering a significance level of 5%. Results: Patients ingested raw cornstarch in the amount of 0.49 to 1.34 g/kg/dose at a frequency of six times a day, which is lower than recommended (1.75-2.50 g/kg/dose, four times a day). The amount of energy intake was, on average, 50% higher than energy requirements; however, carbohydrate intake was below the adequacy percentage in 5/11 patients. Short stature was found in 4/10 patients; obesity, in 3/11; and muscle mass deficit, in 7/11. There were no statistical differences between the subgroups. Conclusions: In patients with glycogenosis type I, there was deficit in growth and muscle mass, but no differences were found between the subgroups (Ia and Ib). Although the diet did not exceed the adequacy of carbohydrates, about 1/3 of the patients presented obesity, probably due to higher energy intake.
AVAILABILITY AND STORAGE OF HAZARDOUS PRODUCTS IN HOUSEHOLDS IN THE METROPOLITAN REGION OF MANAUS: A POPULATION-BASED SURVEY, 2015
Authors: Tiguman Gustavo Magno Baldin , Almeida Marina Borges Dias de , Silva Marcus Tolentino , Galvao Tais Freire
Published: February 2021

ABSTRACT Objective: The availability of hazardous products in households increases the risks of poisoning. The present study aimed to assess the frequency and associated factors of the availability and storage of hazardous products in residences in the metropolitan region of Manaus. Methods: Population-based and cross-sectional study conducted in 2015 with adults selected with three-stage probabilistic sampling. Participants were interviewed face-to-face. Prevalence ratio (PR) of the presence of hazardous products (presence of chumbinho [illegal anti-cholinesterase rodenticide], artisanal cleaning products, and unsafe storage of these products and medications) and 95% confidence intervals (95%CI) were calculated with Poisson regression with robust variance, weighted by the complex sampling method adopted. Results: A total of 4,001 participants was included, of which 53.0% (95%CI 51.5-54.6) reported presence of hazardous products in their households, 36.3% (95%CI 34.8-37.8) had unsafe storage, 16.2% (95%CI 15.1-17.4) had artisanal cleaning products, and 8.2% (95%CI 7.4-9.1) had chumbinho. Households with children ≤5 years old had safer storage (PR=0.78; 95%CI 0.71-0.86) and more artisanal products (PR=1.30; 95%CI 1.11-1.51). Presence of artisanal products was higher in lower educational levels (PR=2.20; 95%CI 1.36-3.57) and lower economic classifications (PR=1.63; 95%CI 1.25-2.13). Conclusions: Over half of the households in the metropolitan region of Manaus kept hazardous products; one-third stored them unsafely. Artisanal cleaning products and chumbinho were frequently present. Households with children had safer storage of products, and socioeconomic factors affected the availability of such hazardous products.
SARS-CoV2 S Protein Features Potential Estrogen Binding Site
Authors: Tomasović Ante , Stanzer Damir , Svetec Ivan Krešimir , Svetec Miklenić Marina
Published: February 2021

Research background. During the current SARS-CoV2 pandemic, as well as earlier SARS and MERS epidemics, it has been observed that COVID19-positive women on average tend to have milder symptoms and lower fatality rates than men. There is a number of differences between the sexes known to contribute to different immune responses and severity of the disease, one being the effect of estrogen via estrogen receptor signalling. We wondered if estrogen might also affect the SARS-CoV2 more directly, perhaps by binding to the surface glycoprotein (S protein), thus possibly reducing its infectivity.

Experimental approach. To assess whether there is a possibility for estrogen binding on the SARS-CoV2 S protein we used BLAST and HHpred to compare protein sequences of S protein and human estrogen receptor β, while 3D structures of a potential estrogen binding site and an active site of estrogen receptor β were visualized and compared using PyMOL.

Results and conclusions. By comparing the protein sequence of SARS-CoV2 S protein with the human estrogen receptor β, we identified a potential estrogen binding site on S protein and further determined that it also shares notable similarities with the active site of ER β when observed in 3D structure of their respective proteins. As a control, SARS-CoV2 S protein was compared with the human androgen receptor, and no such similarities were found. The potential estrogen binding site is part of coronavirus S2 superfamily domain, which is involved in host-virus membrane fusion during infection and appears to be conserved throughout the Coronaviridae family.

Novelty and scientific contribution. This preliminary communication shows that SARS-CoV2 S protein features a potential estrogen binding site. Hopefully, this will prompt a more comprehensive study on the possibilities of estrogen binding on the S protein and the effect this might confer on the virus infectivity.
Демографическое будущее Китая
Authors: Селиверстова Юлия Андреевна
Published: February 2021

Статья посвящена прогнозу развития демографической ситуации в КНР до 2030 г. Дается характеристика текущих демографических изменений, таких как стремительное старение населения, снижение рождаемости, половой дисбаланс, трудовая миграция из села в город, активный процесс урбанизации. Показано, что острота существующих социальных вопросов во многом обусловлена политикой ограничения рождаемости в стране, проводившейся на протяжении 35 лет. Распространение малодетности и ценностей современной городской среды значительно изменили форму семьи и ее функции. При сохранении существующих тенденций население Китая в размере 1,4 млрд человек через 8 лет исчерпает потенциал к росту, начнется естественная убыль. При увеличении числа пожилых людей и высокой продолжительности жизни трудоспособное население будет сокращаться, еще сильнее уменьшится количество детей в возрасте до 14 лет. Окончание действия демографического дивиденда для экономического развития КНР сопряжено с ростом социальной напряженности. В ближайшие годы значительно возрастет нагрузка на систему городской прописки, социального обеспечения и здравоохранения. Для эффективного противодействия нарастающему кризису правительству страны необходимо уделить повышенное внимание решению проблем сельских жителей, реформированию системы пенсионного и медицинского страхования, укреплению института семьи, мерам по поддержке семей с детьми.
Immunofluorescent methods for antibody test in mouse colon v1
Authors: Wang Lixin , pq Yuan Pu-Qing , Liang Honghui , Tache Yvette
Published: February 2021

A table listed the information of antibodies used in the mouse colon. The protocol described the methods of colon tissues sampling, whole mount preparations, passive clarity technique, and respective fluorescent Immunohistochemistry for the antibody tests in different tissue preparations.
Experiments in physics teaching: Towards an approach to laboratory skills development
Authors: GKİOKA Olga
Published: February 2021

The aim of the present paper is to report on a research study which
aimed to promote the idea that experiments in physics teaching should enhance
the development of laboratory skills. The paper begins with a discussion of the
role of laboratory work, as presented in different curricula in Europe and the
US. Emphasis has been given to curriculum guidelines, according to which,
laboratory work should promote the development of laboratory skills. Then, an
empirical research study with one hundred and twenty-three (123) pre-service
physics teachers has been reported. The study took place within the context of
a pre-service teacher education program in a Department of Physics Teaching.
The participants were distributed in six different semesters during three years.
They performed experiments, wrote laboratory reports and prepared lesson plans
to teach in the school laboratory. In addition, short interviews were conducted
with quite many of them, while preparing lesson plans. The research goal was to
investigate teachers’ understanding of the purpose of experiments in physics
teaching and their difficulties when preparing lesson plans to teach in the
lab. The program was successful in helping the participants to gradually
‘shift’ from the idea that experiments are used to verify a hypothesis or
confirm theory, to the position that experiments should promote the development
of laboratory skills. Implications for curriculum development and pre-service
teacher education in Turkey have been discussed.
Scalability analysis of selected structures of a reconfigurable manufacturing system taking into account a reduction in machine tools reliability
Authors: Gola Arkadiusz , Pastuszak Zbigniew , Relich Marcin , Sobaszek Łukasz , Szwarc Eryk
Published: February 2021

Scalability is a key feature of reconfigurable manufacturing systems (RMS). It enables
fast and cost-effective adaptation of their structure to sudden changes in product demand.
In principle, it allows to adjust a system's production capacity to match the existing orders. However, scalability can also act as a "safety buffer" to ensure a required minimum
level of productivity, even when there is a decline in the reliability of the machines that
are part of the machine tool subsystem of a manufacturing system. In this article, we
analysed selected functional structures of an RMS under design to see whether they
could be expanded should the reliability of machine tools decrease making it impossible to achieve a defined level of productivity. We also investigated the impact of the
expansion of the system on its reliability. To identify bottlenecks in the manufacturing
process, we ran computer simulations in which the course of the manufacturing process
was modelled and simulated for 2-, 3-, 4- and 5-stage RMS structures using Tecnomatix
Plant Simulation software.
UPBRINGING STUDENTS' VALUE ATTITUDE TO FUTURE PROFESSIONAL ACTIVITY IN SCIENTIFIC-PEDAGOGICAL HERITAGE OF UKRAINIAN SCHOLARS-PEDAGOGUES
Authors: Levytska L.
Published: February 2021

The article deals with the problem of upbringing students' value attitude to work, future professional activity in a higher educational institution. On the basis of the analysis of the scientific-pedagogical heritage of Ukrainian scholars-teachers, the evolution of the socio-moral essence of work in the history of mankind, the transformation of awareness of work as a vital value in modern society has been presented. The theoretical foundations of the upbringing of the value attitude to work have been determined, the peculiarities of organization of upbringing process in higher educational institutions have been researched; the technology of organization of the process of upbringing students' value attitude to work in the conditions of a higher educational institution has been substantiated, the psychological-pedagogical conditions of its implementation have been characterized; the levels of formation student's value attitude to work has been defined on the basis of developed criteria and indicators; the essence of the technology of upbringing students' value attitude to work has been revealed.
PRACTICAL TRAINING OF PROFESSIONALS IN THE HIGHER EDUCATION SYSTEM OF INDEPENDENT UKRAINE
Authors: Zhylenko M.
Published: February 2021

The paper analyzes approaches to practical training organization in Ukrainian system of higher education in the period – the end of the 20th – beginning of the 21st century. Particular emphasis is placed on modern requirements. Exclusive attention is paid to the analysis of the modern educational paradigm. The process of changing the requirements for practical training in accordance with the transformational processes taking place in the system of higher education in Ukraine is considered in detail. Tasks of practical training are considered in the framework of modernization of educational and professional standards, requirements of the legislative and regulatory framework, creation of conditions for the involvement in the processes of building a new innovative National Qualifications System (NQS). Practical training is considered through the normative content of the training of higher education graduates, formulated in terms of programmatic learning outcomes and correlated with a specific list of general and special (professional, subject) competencies. Tasks for practical training of students are considered as a component of the whole educational program, which should be integrated into its philosophy and content and ensured by the procedure for determining the place of practical training in the matrices of matching competencies and program learning outcomes.
MOLECULAR DYNAMICS SIMULATIONS OF STRUCTURAL PROPERTIES OF CuNi ALLOYS DURING THE COOLING PROCESS AT HIGH PRESSURE
Authors: Nguyen Thi Thao , Bui Thi Ha Giang , Tran Phan Thuy Linh , Nguyen Van Hop , Pham Do Chung , Pham Van Hai , Nguyen Thi Huyen Trang
Published: February 2021

Molecular dynamics simulations of Cu80Ni20 (Cu:Ni = 8:2) model with the size of 8788 atoms have been carried out to study the structure and mechanical behavior at high pressure of 45 GPa. The interactions between atoms of the system were calculated by the Quantum Sutton-Chen embedded-atom potentials. The crystallization has occurred during the cooling process with a cooling rate of 0.01 K\ps. The temperature range of the phase transition is determined based on the sudden change of atomic potential during the cooling process. There is also a sudden change in the number of individual atoms in the sample. At a temperature of 300 K, both Ni and Cu atoms are crystallized into the face-centered cubic (FCC) and the hexagonal close-packed (HCP) phases, respectively. The mechanical characteristics of the sample at 300 K were also analyzed in detail through the determination of elastic modulus, number of atoms, and void distribution during the tensile process.
A ROLE OF WILD BIRD POPULATION IN THE TRANSMISSION OF PARASITIC FLATWORMS (PLATYHELMINTHES: CESTOIDEA AND TREMATODEA) IN VIETNAM’S FOREST
Authors: Georgiev B. Boyko , Mariaux Jean , Vasileva P Gergana , Nguyen Quoc Huy , Vu Quang Manh
Published: February 2021

The study aimed to evaluate the role of transmitting flatworms (Cestoidea and Trematodea) of wild bird populations in three national parks of Vietnam: Xuan Son in the Northwest mountainous region, Tam Dao in the Northeast mountainous region, and Cat Ba in the Hong River Delta region. Twenty-two wild avian species of 10 families were found to contain parasitic flatworms. According to the number of avian species containing parasitic flatworms, bird families are ranking: Timaliidae recorded with 7 species > Leiothrichidae and Nectariniidae both with 3 species > Pycononotidae and Muscicapidae both with 2 species > Vireonidae, Sylvidae, Picidae, Cisticolidae and Cettiidae with 1 species. According to sex, avian populations containing parasitic flatworms decrease in the order: females accounting for 43.94% of the total individuals > males for 39.40% > juveniles for 16.66%. Three bird species containing flatworms A. pallidus, M. gularis and C. bayumas were found in two of the studied national parks, among them, only the first species was found common to all three studied national parks. They are vectors of high significance from a parasitological point of view.
Methylen tetrahydrofolate reductase enzyme gene C677T and A1298C mutations in primigravida with first trimester missed abortion: cross-sectional study
Authors: Mohamed Hefila Nermeen
Published: February 2021

Background: This work aimed to correlate between MTHFR C677T and A1298C genes (methylenetetrahydrofolate reductase) mutation and first trimester missed abortion in primigravida to identify pregnant ladies who need anticoagulation therapy to improve pregnancy outcome. The conducted study was a cross-sectional study. Data were collected from females recruited from EL Shatby hospital, Alexandria, Egypt. The present study was done on 40 primigravida females recruited from EL Shatby hospital. Methods: All participating women were primigravida in their first trimester with missed abortion. Blood specimens were collected from all cases involved in the study for DNA extraction and genotype analysis based on PCR and reverse hybridization. The mutations studied are the MTHFR C667T and A1298C genes. Main outcome measures: The MTHFR C667T mutations in our study is not significantly related to abortion in primigravida while MTHFR A1298C mutations prevalence were appeared significantly have a relation to abortion.Results: In the current study, the prevalence of MTHFR A1298C mutations was in 52.5% of cases, with homozygosity in 15 % of cases and heterozygosity in 37.5% of cases. However, the total prevalence of the MTHFR C667T gene mutations was 30% of cases only and all are heterozygous. Four cases were prevalent with combined thrombophilia (MTHFR C677T and A1298C) in the participating cases. Finally, the number of individuals were assessed for each of the gene mutations based on of homozygous or heterozygous. No homozygous cases were detected for MTHFR C667T gene mutation.Conclusions: In this current study, there is an association between miscarriage and thrombophilia.
Application of interactive education in rural elderly diabetic patients with conversation map
Authors: Yingli Zhang , Mingyun Niu , Cuiqin Zhang
Published: February 2021

Background: The purpose of this study is to explore the effect of health education with conversation map on self-management ability of rural elderly diabetic patients.Methods: 60 rural elderly diabetic patients in endocrinology department of a 3A hospital from January to December in 2019 were selected as the research objects. According to the parity of the last two digits of the hospitalization number, the odd number was divided into the control group and the even number was divided into the experimental group. The control group was given traditional health education and interactive education with conversation map was added to the experimental group. After 3 months of intervention, fasting blood glucose, 2 hours postprandial blood glucose, glycosylated hemoglobin and self-management behavior of the two groups were observed.Results: The fasting blood glucose, 2h postprandial blood glucose, glycosylated hemoglobin and self-management ability of the experimental group were significantly better than those of the control group and the difference was statistically significant (p<0.05).Conclusions: The interactive education with conversation map can effectively improve the self-management ability of rural elderly diabetic patients, and then prevent the occurrence of diabetic complications.
AS HERANÇAS SEMITA E GREGA NA COMPREENSÃO DO LOGOS JOANINO
Authors: Artuso Vicente , Da Silva Maycon Renan
Published: February 2021

O conceito Logos utilizado no Prólogo de João em 1,1 é identificado com Deus. O Logos é pré-existente, porém em 1,14 o Logos aparece na carne, habitando com a humanidade. Sua origem é helênica, mas utilizado pelo evangelista adquire o sentido de vida e salvação em Cristo. O artigo aborda como o Logos Joanino teve influência semita no Dabar, na Memrá rabínica, na tradição sapiencial e em Filon de Alexandria. Essa apropriação do Logos helênico, em vista dos objetivos de João tem influência semita, pois no Antigo Testamento a palavra também realiza o que significa. E em João o Logos é palavra que se fez carne em vista da salvação.
REPRESENTAÇÔES SOCIAIS DE DEUS PARA PARTICIPANTES DE FESTIVIDADES CATÓLICAS NA CIDADE DO RIO DE JANEIRO
Authors: França Luiz Carlos Moraes , Tosoli Gomes Antônio Marcos , Pecly Wolter Rafael Moura , Collares-da-Rocha Julio Cesar Cruz , Santos Couto Pablo Luiz , Santana Peixoto Álvaro Rafael , Pereira Gerson Lourenço , Figueiredo Nogueira Virginia Paiva , Santos Charles Souza
Published: February 2021

A religiosidade e a espiritualidade sempre foram vivenciadas e se apresentam como uma dimensão da pessoa humana, dando-lhe um quadro de interpretação da realidade, de suas vivências e de suas experiências. O presente estudo está alicerçado na sobre a Teoria das Representações Sociais, com a qual se busca compreender as representações construídas pelos participantes de duas festividades católicas realizadas no município do Rio de Janeiro, dedicadas a São Sebastião e São Jorge a partir do termo indutor “Deus”.
JOÃO CABRAL DE MELO NETO: UMA PEREGRINAÇÃO SEVERINA
Authors: Brissos-Lino José
Published: February 2021

O desafio a que nos propomos neste artigo é comparar o movimento migratório dos retirantes do nordeste brasileiro do séc. XX, tipificado na forma poética por João Cabral de Melo Neto, com um outro, mais individual, representado por uma natureza onírica, formulado em prosa por John Bunyan, na Inglaterra setecentista. Referimo-nos à obra icónica do protestantismo do séc. XVII, “O Peregrino”. Procuramos entender que relações poderão ser estabelecidas entre ambas as narrativas peregrinadoras, tendo em conta as evidentes diferenças de estilo literário, enquadramento histórico e religioso, e intenções presumidas dos autores, e ainda de que forma ambos estabelecem um discurso dialéctico com a finitude e a morte.
TESES PPGCR 2020
Authors: Richter Reimer Ivoni
Published: February 2021

Apresentação de autoria e título de teses defendidas em 2020.
Ejercitar al cuerpo: la gimnasia femenina en el Colegio de la Paz (Vizcaínas), 1875-1915
Authors: Galán Tamés Genevieve
Published: February 2021

El artículo analiza la introducción de la gimnasia en el Colegio de la Paz y algunos aspectos vinculados a su implementación de 1875 a 1915. A partir del estudio de este espacio, el texto ahonda en ciertas condiciones de posibilidad históricas que permiten pensar la ejercitación corporal y la introducción de la educación física en México, dentro del espacio escolar. Vizcaínas puede utilizarse como ilustración del proyecto que una elite profesional y política –comprometida con la educación de la mujer y la consolidación de la educación física, higiénica y moderna– buscó implementar como pauta general en los colegios del país. El texto apunta que la introducción de la gimnasia en el ámbito escolar implicó la gradual consolidación de un sistema de lectura y evaluación del movimiento del cuerpo. Asimismo, ofrece indicios de la formación de profesoras de gimnasia en un periodo en el que la educación física se estaba profesionalizando.
Extracción de plaguicidas en el aguacate Hass (Persea americana Mill. cv.) mediante el uso de C18 y arcillas funcionales como fase adsorbente en la metodología QuEChERS
Authors: Betancourt-Arango Juan Pablo , Ossa-Jaramillo Cesar Augusto , Taborda-Ocampo Gonzalo
Published: February 2021

La agenda interna de competitividad del departamento de Caldas incluye el aguacate Hass como uno de los productos hortofrutícolas de mayor importancia y proyección en la región. Dadas las condiciones favorables del trópico y la gran biodiversidad de plagas, es necesario el uso de plaguicidas para su control, lo que conlleva un potencial peligro para la salud de los consumidores por los residuos de estos químicos tóxicos en el producto final. El interés del presente estudio es la inocuidad alimentaria del aguacate Hass, para lo cual es necesario implementar y validar metodologías de análisis de plaguicidas organoclorados y organofosforados. Se hicieron análisis en las cáscaras y la pulpa de aguacates Hass con la metodología QuEChERS comparando el uso de dos fases adsorbentes, el C18 y las arcillas funcionales, con el fin de obtener una mezcla de analitos que luego fueron separados e identificados por cromatografía de gases con un detector de microcaptura de electrones (GC - µECD) para los compuestos organoclorados, y por cromatografía de gases con detección de nitrógeno y fosforo (GC - NPD) para los compuestos organofosforados. La metodología QuEChERS asociada con arcillas funcionales resultó más eficiente que la extracción con fase C18 según los valores de resolución promedio de 3,44 en cáscara y de 2,12 en pulpa. El uso de esta nueva fase adsorbente facilitó la separación, generó una mayor resolución y extrajo de una mejor manera los plaguicidas presentes en la matriz.
The Influence of Discovery and CORE (Connecting, Organizing, Reflecting, and Extending) Learning Model on Students’ Creative Thinking Skill
Authors: Prastika Veronika Yusnita Andriani , Riyadi Riyadi , Siswanto Siswanto
Published: February 2021

The topic currently discussed in Indonesia is the industrial revolution 4.0. One of the skills that cover the 4.0 industrial revolution is creative thinking. The ability to think creatively must be developed from the early age. One of which is by applying a learning model in accordance with the students’ condition. In reality, Mathematics has not applied a learning model that triggers students' creative thinking skills. Furthermore, the question of creative thinking is currently experiencing a decline which can be seen in the average score of the national exam. Researchers concluded that students and teachers have not found the right learning model for creative thinking problems. The population in this research were eighth-grader of junior high school in Madiun Regency. Therefore, the main focus is to apply the discovery and CORE learning model, and to see how the effects of the discovery learning model and the CORE learning model. Then data analysis method used is one way univariate analysis of variance.
Innovation in the Management of Sustainable Environmental Study Tourism Park (TWSL) in Probolinggo
Authors: Krisyanto Budi , Supriyono Bambang , Setyowati Endah , Ciptadi Gatot
Published: February 2021

Local diversity through site-dependent activities such as tourism and resource-based recreation, as well as resource extraction, may offer opportunities for regional development and restructuration. The small number of open spaces in urban areas is a factor in the considerably high pressure of life in the city center. Therefore, the existence of public open spaces in the city center, especially green open spaces in urban areas, is needed because of its function and role as a place for socialization and recreation as well as an alternative rest area with its fresh air in the midst of hectic activities in the city center. Public open space also serves as a place for people to relieve fatigue after a long hard work at a very low cost. This research aims to analyze the effectiveness and the efficiency of the management of the Environmental Study Tourism Park in the City of Probolinggo. The management of urban forest in the former “red are” idle land for ecological, educational and socio-economic purposes as a manifestation of public green open space in urban areas is developed into an Environmental Study Tourism Park. Based on the results of research on the performance of the government/management in providing services to the community regarding environmental education information is considered to be good enough because it is supported by certified experts in accordance with their fields and provide convenience to the community/educational institutions in terms of visiting and learning flora and fauna.
Ecological Damage in the novel of Mata dan Manusia Laut by Okky Madasari
Authors: Atikah Atikah , Winarni Retno , Wardani Nugraheni Eko
Published: February 2021

Natural problems are the main issues which is related to the human attitudes and behaviours. There is a reciprocal relationship between human and nature. Ecological damage affects the life of organisms or other biotic and abiotic elements. In literary discourse, the author could show the destruction of nature. The purpose of this study is to describe the natural problems in Okky Madasari's novel Mata dan Manusia Laut. This study used a qualitative method with a descriptive analytic working mechanism. The approach used was an ecocritical approach. The data collection technique applied was documentation. The data analysis activities consisted of data reduction, data presentation, and drawing conclusions/verification. The results showed that the natural problems contained in the novel of Mata and Manusia Laut were natural problems and artificial or influenced by human behaviour. Non-anthropocentric problems were weather problems in Kaledupa and Masalembo, high waves caused by the gravity of the moon, tsunamis, and earthquakes. Meanwhile, the problems that were directly influenced by the attitudes and behaviours of the characters consisted of the problem of fish bombs, sea water pollution with garbage, and the death of the mother octopus. The results of this study could be used to strengthen the character and attitude of loving the environment.
Reflection of Character Education Value through Depictions of Characters in Oka Rusmini's Koplak Novel
Authors: Suryanto Suryanto , Andayani Andayani , Wardhani Nugraheni Eko
Published: February 2021

This research aims to describe the character education value reflection through characters' depiction in Oka Rusmini's novel Koplak. This research is descriptive qualitative research. The approach used in this research is psychological. The data collection technique used was a documentary study. The data source in this research is the novel Koplak by Oka Rusmini. This study's data are character education value reflections through the depiction of the character in the data source, that is Koplak novel by Oka Rusmini. The data were collected using the reading technique and note-taking technique. The data analysis uses an interactive-analysis method. This study results indicate that there are reflections of character education value through the character depiction in Oka Rusmini's novel Koplak, namely honest, caring, and attention.
Synchronizing Students Learning Styles in Promoting Learners’ Grammatical Knowledge; a Cultural Dimensions Study
Authors: Hasib Mujib , Yassi Abdul Hakim , Nasmilah Nasmilah
Published: February 2021

This study aims to examine learning styles based on cultural dimensions theory’s hypothesis. The research focuses to investigate whether styles from cultural view provide an exact description of students’ learning styles and to describe the exactitude of current concept of the theory’s hypothesis. The study employs quasi-experimental design which clusters the experimental design into control and experimental group. In collecting the data, cultural dimensions questionnaire was used to determine students learning styles. As instructed by cultural dimensions theory, one group was assigned with students-centered learning and one was with teacher centered learning. One Way Anove test was conducted to determine the sample homogeneity. The statistical analysis uses Wilcoxon Statistic Test to compare the results of control group and experimental group. The result of experimental group shows moderate learning outcome significance compared to control group. The result is not necessarily significant but consistent. The study suggests that empowering students learning styles will help students learn better compared to conventional teaching.
Janus Faced of Women's Parliament Family Line: Representation of Women in Politics and Party Oligarchy
Authors: Azis Ardhana Ulfa , Siscawati Mia
Published: February 2021

The implementation of affirmative quota policies by political structures, especially political parties as one of the elements of the political infrastructure, has provided the widest possible opportunity for women to be directly involved in the political process, such as becoming members of parliament to carry out over sight, budgeting, and legislative functions: the making and policymaking and political decisions. This research examines how women in the family path of the 2019’s election results, on the one hand, their faces are seen as political representatives of women in parliament, but on the other hand, they are also seen as representatives of the interests of party oligarchy in parliament. We explored the filling of affirmative quotas for female parliamentary candidates from the family line by political parties which allowed us to identify women parliamentarians from the family line as having two faces, namely as women's political representatives as well as party political representatives. In a stronger party oligarchy, we argue that filling the affirmative quota of female parliamentary candidates from the family line apart from being urged by the affirmative quota policy for 30%women's political representation, is also motivated by the interests of party oligarchy. We adopt the thoughts of Anne Phillips (1991) about the politics of presence which sees that women's representation in parliament starts from the number, not from the policies they produce.
Larvicidal Activity of Entomopathogenic Nematodes Isolated from Mexico against Aedes aegypti (Diptera: Culicidae)
Authors: Treviño-Cueto Diego , Subbotin Sergei A. , Sanchez-Peña Sergio R.
Published: February 2021

Entomopathogenic nematodes (EPNs) are widely used agents of biological control, mainly targeting soil-inhabiting insect pests. Reports indicate that these terrestrial EPNs are also able to infect the aquatic larvae of mosquitoes. We isolated EPN strains (Heterorhabditis bacteriophora Poinar and Steinernema carpocapsae [Weiser]) from local soils at Saltillo, Coahuila state, Mexico. EPNs from these strains were produced in the laboratory in yellow mealworm (Tenebrio molitor L.) larvae, and their pathogenicity as infective juveniles (IJs) was tested against larvae of the yellow fever mosquito Aedes aegypti (L.) Third- and fourth-instar mosquito larvae were exposed to four concentrations of IJs (25, 50, 100, and 200 IJ/larva) of five strains of local EPNs in laboratory assays. All strains of EPN caused lethal infections in larvae (3–100%); in particular, strain M5 of S. carpocapsae caused 100% mortality at the 200 IJ/larva concentration, with a median lethal concentration (LC50) of 42 IJ/larva (LC90 = 91 IJ/larva). Strain M18 of H. bacteriophora caused 73% mortality at 200 IJ/larva, with an LC50 = 72 and LC90 = 319 IJ/larva. IJs were produced by all strains in mosquito larvae, with a range of 66–239 IJ/mosquito larva (inoculated at 100 IJ/larva) across strains, suggesting that horizontal transmission might occur in the field. This represents the first report of native EPN strains from Mexico exhibiting pathogenicity against mosquito larvae. Native EPN strains should be further evaluated as potential biological control agents in mosquito management.
IMMUNE REGULATION OF HEMOSTASIS IN INFLAMMATORY PERIODONTAL DISEASES CADETS OF UFA LAW INSTITUTE OF THE MINISTRY OF INTERNAL AFFAIRS OF THE RUSSIAN FEDERATION
Authors: Sitdikova Olesya , Kabirova Milyausha , Gubina Oksana
Published: February 2021

Subject. Inflammatory periodontal diseases are accompanied by violations of the body's reactivity to the introduction of the pathogen. At various stages of the immune response, Pro-inflammatory cytokines are produced, such as interleukins 1, 6 (IL-1, IL-6), tumor necrosis factor-alpha (TNF-α), and chemokines in particular IL-8. Cytokines serve as an organizing system that forms and regulates the entire complex of protective reactions of the body, provides activation of various types of cells, including white blood cells, dendritic, endothelial, epithelial cells, fibroblasts, macrophages, lymphocytes, and others. They cause endothelial activation, leading to increased permeability, increased expression of adhesive molecules, and increased procoagulant activity. The appearance of interleukins in the focus of inflammation causes the production of tissue factor, Willebrand factor, plasminogen activators, etc., which stimulate the reactions of vascular-platelet hemostasis, which activate the Pro-enzyme-enzyme cascade of blood clotting and fibrinolysis.

The aim — to study the effect of cytokines on the hemostatic system in individuals with healthy periodontitis, chronic gingivitis, and chronic generalized periodontitis.

Methodology. 60 cadets aged 18 to 25 years participated in the clinical study at the dental office of the medical unit No. 1 of the medical and sanitary unit of the Ministry of Internal Affairs of the Russian Federation (Ufa). The study group consisted of 45 people: 15 patients with intact periodontitis, 15 patients with moderate chronic gingivitis, and 15 patients with moderate chronic generalized periodontitis.

Results. Correlations between IL-1β, IL-6, TNF-α, and IL-8 in gingival sulcus flushes, pockets, and hemostasis parameters were revealed.

Conclusions. In inflammatory periodontal diseases, interleukins can inhibit fibrinolysis, leading to hypercoagulation. Increased thrombosis contributes to the progression of gingivitis to periodontitis.
Regioselective Synthesis of Some Rhamnopyranoside Esters for PASS Predication, and ADMET Studies
Authors: MATİN Mohammed Mahbubul , ISLAM Naimul , SİDDİKA Aysha , BHATTACHARJEE Sreebash C.
Published: February 2021

Notable biological activities including brains protective activities have made carbohydrate esters as a topic of great interest over the past several decades. In this context, unimolecular treatment of methyl α-L-rhamnopyranoside (3) with dibutyltin oxide gave the corresponding 2,3-O-(dibutylstannylene) derivative which was then allowed to react with 3-chlorobenzoyl chloride. The reaction regioselectively furnished the 3-O-substitution product 4 in excellent yield. To get newer rhamnopyranoside esters chlorobenzoate 4 was further converted into four 2,4-di-O-substituted products 5-8 with other acylating agents using direct acylation technique. Moreover, thermodynamic properties indicated that these SEs possess better stability, suitable polar nature and higher binding affinity than the non-ester rhamnopyranoside 3. PASS (Prediction of Activity Spectra for Substances) predication showed that these SEs should be more potent against fungal pathogens than the bacterial organisms. With these encouraging results ADMET and drug-likeness properties of the SEs 4-8 are also discussed.
Comparative analysis of clustering techniques in the internet of things
Authors: Mohammed Ahmed Burhan
Published: February 2021

One of the most important topics in the last decade is the Big Data (BD) and how to link it and benefit from its consumption in different fields, included as the introduction in this research analysis of the BD belonging to devices of the Internet of Things. The concept of managing objects and exploring devices is connected to the Internet and sensors deployed in the world, all these devices are pumping a lot of data through the Internet of Things (IoT) into the world. In order to make the right decisions for people and things, BD using data mining techniques and machine language algorithms help make decisions. The Internet of Things that insert large amounts of data need to be studied, analysed and disseminated in order to access valuable, useful and bug-free information for the purpose of making the right decision and avoiding problems. In this paper, two clustering algorithms simple K-means and self-organising map (SOM) in IoT are presented. Next, comparing the clustering models’ output in the IoT data set that improved the SOM is better than K-means, but it is slower in creating the model.
 
Keywords: Internet of things (IoT), big data, machine learning, filtered cluster, K-means, SOM.
Characteristics of Goat Ovarium Granulosa Cells With Extract Leaves ‎‎(Schleichera oleosa) at Different Passage Levels in Vitro
Authors: Hanifah Lil , Muti’ah Roihatul
Published: February 2021

S. oleosa belongs to the Sapindaceae family and has phytochemicals phenolic acid so that it has enormous benefits in the process antioxidant. The presence of antioxidant activity in cells can affect the defense of the cell protein membrane, so that the ability of cells to perform division is optimal. In vitro this is mostly done by adding hormones to cell culture media or natural compounds to increase cell proliferation. Every population of cell that has undergone division during the proliferation process to confluent is an indication that the cell is aging. This study was an experimental study was designed using a completely randomized design (CRD) with 5 treatments and 5 replications as follows: K0: granulose cells and culture media without treatment (0 µl), P1: granulose cells and culture media with 1% kesambi leaf extract. (30 µl), P2: granulose cells and culture media given kesambi leaf extract 1.5% (45 µl), P3: granulose cells and culture media given kesambi leaf extract 2% (60 µl) and P4: granulosa cells and The culture media was given 2.5% (75 µl) to the leaves extract., the characteristics of goat ovarian granulosa cells by giving kesambi (Scheichera oleosa) leaf extract at different passages were at the level of confluence showing the highest value in passage I, namely treatment P1. Meanwhile, the level of viability shows the highest value in section I, namely the P4 treatment
Family functioning and dental trauma, malocclusion and anthropometry in adolescents
Authors: Sousa Adelaine Maria de , Silva Thais Carine Lisboa , Vaigel Bruna de Carvalho , Pinho Roberto Carlos Mourão , Cimões Renata
Published: February 2021

Aim: The aim of the study was to investigate perceived family cohesion and adaptability and its association with trauma, malocclusion and anthropometry in school adolescents. Methods: Cross-sectional study with a representative sample of 921 adolescents from 13 to 19 years old of both sexes, enrolled in state public schools of a northeastern Brazilian municipality. A questionnaire with sociodemographic questions, the FACES III scale was applied and a clinical oral examination (dental trauma and malocclusion) and anthropometric (BMI by age) were performed. For statistical analysis, was evaluated by the Chi-square test. The variables that presented significance in the bivariate analysis of up to 25% were taken to the multivariate analysis (multinomial logistic regression), variables that presented significance in bivariate analysis of up to 25% were taken to multivariate analysis and all conclusions were drawn considering the significance level of 5%. Results: As a result, it was identified that displaced families were associated with low maternal education, agglutinated families associated with the absence of caries. Rigid families were associated with marked overjet and caries. The prevalence of dental trauma (37.5%) was considered high. Conclusion: It was concluded that family cohesion and adaptability were associated with oral health and socioeconomic factors.