bluuebunny/crossref_metadata_2025 huggingface dataset:
British Privateering Voyages of the Early Eighteenth Century
Authors: Beattie Tim
Published: December 2015

The three great privateering expeditions into the South Sea, which set out, respectively, in 1703, led by William Dampier; in 1708, led by Woodes Rogers; and in 1719, led by George Shelvocke, were costly and ambitious long distance voyages, carrying great risk for their investors but promising great reward. This book tells the story of the voyages and their impact. It argues that, far from being anachronistic activities more in keeping with an earlier age, as some scholars have asserted, the voyages were significant events and had a huge impact - on politicians, influencing future maritime and naval strategy; on investors, swelling enthusiasm for the South Sea Company which ended in the disastrous Bubble; and in literature, where the narratives of the voyages became an important source for some of the greatest literature of the period, including Robinson Crusoe, Gulliver's Travels and The Rime of the Ancient Mariner. The book provides a great deal of original detail about the voyages, including the difficulties of undertaking such lengthy expeditions, unrest among the crews, and financial details of investmentsand returns - and losses. Tim Beattie completed his doctorate at the University of Exeter.
Minding the Gap: Extending Mindfulness to Safety-Critical Occupations
Authors: Huber Kelli E. , Hill Sarah E. , Merritt Stephanie M.
Published: December 2015

In their focal article, Hyland, Lee, and Mills (2015) discuss several potential areas in which mindfulness interventions may improve work performance. Some of these include creativity and sales performance (Chaskalson, 2011; Seligman, 2006). We agree that future research should continue to examine the potential benefits of mindfulness and propose an additional domain in which mindfulness interventions may be particularly beneficial: safety performance.
The Big Duplicity of Big Data
Authors: Whelan Thomas J. , DuVernet Amy M.
Published: December 2015

As discussed in Guzzo, Fink, King, Tonidandel, and Landis's (2015) focal article, big data is more than a passing trend in business analytics. The plethora of information available presents a host of interesting challenges and opportunities for industrial and organizational (I-O) psychology. When utilizing big data sources to make organizational decisions, our field has a considerable amount to offer in the form of advice on how big data metrics are derived and used and on the potential threats to validity that their use presents. We’ve all heard the axiom, “garbage in, garbage out,” and that applies regardless of whether the scale is a small wastebasket or a dump truck.
Big Data, Little Individual: Considering the Human Side of Big Data
Authors: Karim Michael N. , Willford Jon C. , Behrend Tara S.
Published: December 2015

Guzzo, Fink, King, Tonidandel, and Landis (2015) provide a clear overview of the implications of conducting research using big data. One element we believe was overlooked, however, was an individual-level perspective on big data; that is, what impact does this sort of data collection have on the individuals being studied? As psychologists, the ethics and impact of big data collection from workers should be at the forefront of our minds. In this reply, we use years of research on electronic monitoring and tracking to provide evidence that an individual-level perspective is an essential part of the discussion surrounding industrial–organizational psychology and big data. Specifically, we examine electronic performance monitoring (EPM) literature to identify how the widespread, pervasive collection of employee data affects employees’ attitudes and behaviors.
Flourishing in the Workplace Through Meditation and Mindfulness
Authors: Davis Donald D. , Bjornberg Nathan H.
Published: December 2015

We believe that Hyland, Lee, and Mills (2015) introduced important considerations concerning the importance of mindfulness for research and practice in industrial and organizational (I-O) psychology, and we applaud their effort. We also feel that some equally important points were neglected or given scant attention. We amplify their introduction in three ways. We discuss (a) how construct confusion is common when new constructs are introduced and how paying attention to the type of meditation practice used to induce mindfulness will enhance construct clarity, (b) how using forms of meditation that employ physical movement and other activities to induce mindfulness expand the choices for intervention and training, and (c) how meditation and mindfulness provide a valuable bridge linking positive psychology and I-O psychology theory and practice.
Making Sure That Mindfulness Is Promoted in Organizations in the Right Way and for the Right Goals
Authors: Hülsheger Ute R.
Published: December 2015

I am happy to see the topic of mindfulness at work find its way into this journal as a focal article (Hyland, Lee, & Mills, 2015), and I read it with great interest. Although I agree with most of the points made, I want to elaborate on some critical issues that were not or were only briefly touched on and that I deem worthy of further exploration and discussion.
The Mesozoic successions of western Sierra de Zacatecas, Central Mexico: provenance and tectonic implications
Authors: ORTEGA-FLORES BERLAINE , SOLARI LUIGI A. , ESCALONA-ALCÁZAR FELIPE DE JESÚS
Published: December 2015

Central Mexico was subject to active tectonics related to subduction processes while it occupied a position in western equatorial Pangea during early Mesozoic time. The subduction of the palaeo-Pacific plate along the western North American and South American active continental margins produced volcanic arc successions which were subsequently rifted and re-incorporated to the continental margin. In this context, the fringing arcs are important in unravelling the continental accretionary record. Using petrographic analysis, detrital zircon geochronology and structural geology, this paper demonstrates that the Guerrero Arc (Guerrero Terrane) formed on top of a felsic volcaniclastic unit (Middle Jurassic La Pimienta Formation) and siliciclastic strata (Upper Triassic Zacatecas Formation and Arteaga Complex) of continental Mexican provenance, deposited across the continental margin and oceanic substrate. This assemblage was rifted away from continental Mexico to form an intervening oceanic assemblage (Upper Jurassic – Lower Cretaceous Las Pilas Volcanosedimentary Complex of the Arperos Basin), then accreted back more or less at the same place, all above the same east-dipping subduction zone. The accretion of the Guerrero Arc to the Mexican continental mainland (Sierra Madre Terrane) caused the deposition of a siliciclastic unit (La Escondida Phyllite), which recycled detritus from the volcaniclastic and siliciclastic underlying strata.
Alterations of mucosa of the larynx and hypopharynx in patients with mucopolysaccharidoses
Authors: Keilmann A , Bendel F , Nospes S , Lampe C , Läßig A K
Published: December 2015

Objective:

This study aimed to: assess the mucosal alterations of the larynx and hypopharynx typical for mucopolysaccharidoses, in a standardised manner; compare the severity in different subtypes of mucopolysaccharidoses; and monitor the effect of an enzyme replacement therapy.

Methods:

A classification for mucosal alterations of the larynx and hypopharynx was developed and utilised in 55 patients with mucopolysaccharidoses. Fifteen patients who started treatment with enzyme replacement therapy were followed longitudinally.

Results:

The most severe alterations were seen in the posterior region of the larynx and the arytenoids, and in the region of the false vocal folds. The alterations were most severe in patients with mucopolysaccharidosis II. No clear trend was observed in the patients who received enzyme replacement therapy.

Conclusion:

Quantification of mucosal alterations of the hypopharynx and larynx in mucopolysaccharidoses patients can provide information about the disease's natural process and about the efficacy of enzyme replacement therapy.
The Declining Role of Latin America in Global Agricultural Trade, 1963–2000
Authors: SERRANO RAÚL , PINILLA VICENTE
Published: December 2015

In the second half of the twentieth century, Latin American countries lost a substantial part of their importance in worldwide exports of agricultural and food products. Given this context, the objective of this article is to analyse the determinants of the evolution of agricultural exports from Latin America, paying special attention to the influence of regional processes of economic integration on exports and to their degree of participation in intra-industrial trade. We propose a gravity model with a data panel of total exports and product groups for six Latin American countries towards 39 destinations between 1963 and 2000.
The impending demise of the item in visual search
Authors: Hulleman Johan , Olivers Christian N. L.
Published: December 2015

The way the cognitive system scans the visual environment for relevant information – visual search in short – has been a long-standing central topic in vision science. From its inception as a research topic, and despite a number of promising alternative perspectives, the study of visual search has been governed by the assumption that a search proceeds on the basis of individual items (whether processed in parallel or not). This has led to the additional assumptions that shallow search slopes (at most a few tens of milliseconds per item for target-present trials) are most informative about the underlying process, and that eye movements are an epiphenomenon that can be safely ignored. We argue that the evidence now overwhelmingly favours an approach that takes fixations, not individual items, as its central unit. Within fixations, items are processed in parallel, and the functional field of view determines how many fixations are needed. In this type of theoretical framework, there is a direct connection between target discrimination difficulty, fixations, and reaction time (RT) measures. It therefore promises a more fundamental understanding of visual search by offering a unified account of both eye movement and manual response behaviour across the entire range of observed search efficiency, and provides new directions for research. A high-level conceptual simulation with just one free and four fixed parameters shows the viability of this approach.
War by other means: Mobile gaming and the 2014 Israel-Gaza Conflict
Authors: Schulzke Marcus
Published: December 2015

The 2014 Israel-Gaza Conflict inspired the creation of over a dozen games for mobile phones and tablets. These games, which allowed players to Bomb Gaza City, operate the Iron Dome missile defence system, and direct rockets into Israeli settlements, marked an important shift in the mediatisation of war in three ways. First, whereas propaganda is frequently described as a top-down process by which elites influence mass audiences, the mobile war games about Gaza were created by non-elite indie game developers, thereby illustrating these games’ capacities for allowing new actors to participate in ideological contestation. Second, the games were not simply reflections on the conflict, but part of it. They were released while the fighting was in progress and helped to constitute the ideological battleground. Finally, the games reproduced established propaganda techniques in distinctive ways that were shaped by the mobile gaming medium.
The cultural ID in the modal system: A contrastive study of English abstracts written by Chinese and native speakers
Authors: Li Weina
Published: December 2015

An abstract is a brief summary of a research paper, review or conference proceeding, which can be considered as a sub-register of academic writing and is often used to help readers quickly ascertain the paper's purpose, thesis, main results and conclusions. With the development of international academic communication, English abstracts play an increasingly vital role in international publishing and academic papers, being the basis for international academic citation indexes. UNESCO prescribes that all published scientific articles, no matter in which language, require a succinct English abstract. Most literature database search engines, such as the EI index, only display abstracts rather than providing the full text of the paper. Since an unsuccessful English abstract would be detrimental to the whole paper as well as to the general quality of the journal, no academic authors would want to lower their guard. In this context, the study of linguistic features of academic abstracts has attracted more and more attention of EAP scholars. The studies on English abstracts in China mainly focus on the writing paradigm as well as such linguistic features as stylistics, textual coherence, grammatical patterns, tense, voice and usage of prepositions (Xiong, 2002; Li et al, 2004; Wang, 2005; Fan, 2006; Li, 2008; He & Cao, 2010).
‘Creeping’ Advisory Jurisdiction of International Courts and Tribunals? The case of the International Tribunal for the Law of the Sea
Authors: RUYS TOM , SOETE ANEMOON
Published: December 2015

On 2 April 2015, the full International Tribunal for the Law of the Sea (ITLOS) rendered its first advisory opinion in reply to a request of the Sub-Regional Fisheries Commission regarding illegal, unreported and unregulated fishing. Unlike any other court or tribunal with advisory competence, including the Seabed Disputes Chamber, ITLOS’ advisory jurisdiction is not explicitly enshrined in its constituent instrument, but was rather asserted in the Tribunal’s, homemade, rules of procedure. In spite of strong objections from various states, ITLOS affirmed a broad advisory jurisdictionratione materiaeandpersonae, and found that there were no compelling reasons to exercise its discretionary power to dismiss the request. The request and the Tribunal's handling thereof raise interesting questions regarding the opportunities and risks inherent to, and the outer limits of, the advisory jurisdiction of international courts and tribunals. This contribution takes a look at the advisory jurisdiction of the full Tribunal, having regard to the experiences of other international courts and tribunals.
THE ASYMMETRIC EFFECTS OF INVESTOR SENTIMENT
Authors: Lutz Chandler
Published: December 2015

We use the returns on lottery-like stocks and a dynamic factor model to construct a novel index of investor sentiment. This new measure is highly correlated with other behavioral indicators, but more closely tracks speculative episodes. Our main new finding is that the effects of sentiment are asymmetric: During peak-to-trough periods of investor sentiment (sentiment contractions), high sentiment predicts low future returns for the cross section of speculative stocks and for the market overall, whereas the relationship between sentiment and future returns is positive but relatively weak during trough-to-peak episodes (sentiment expansions). Overall, these results match theories and anecdotal accounts of investor sentiment.
Disjunctive answer set solvers via templates
Authors: BROCHENIN REMI , MARATEA MARCO , LIERLER YULIYA
Published: December 2015

Answer set programming is a declarative programming paradigm oriented towards difficult combinatorial search problems. A fundamental task in answer set programming is to compute stable models, i.e., solutions of logic programs. Answer set solvers are the programs that perform this task. The problem of deciding whether a disjunctive program has a stable model is ΣP2-complete. The high complexity of reasoning within disjunctive logic programming is responsible for few solvers capable of dealing with such programs, namely dlv, gnt, cmodels, clasp and wasp. In this paper, we show that transition systems introduced by Nieuwenhuis, Oliveras, and Tinelli to model and analyze satisfiability solvers can be adapted for disjunctive answer set solvers. Transition systems give a unifying perspective and bring clarity in the description and comparison of solvers. They can be effectively used for analyzing, comparing and proving correctness of search algorithms as well as inspiring new ideas in the design of disjunctive answer set solvers. In this light, we introduce a general template, which accounts for major techniques implemented in disjunctive solvers. We then illustrate how this general template captures solvers dlv, gnt, and cmodels. We also show how this framework provides a convenient tool for designing new solving algorithms by means of combinations of techniques employed in different solvers.
How did partners experience cancer patients' participation in a phase I study? An observational study after a patient's death
Authors: Langenberg Simone M.C.H. , Peters Marlies E.W.J. , van der Graaf Winette T.A. , Wymenga Anke N. Machteld , Prins Judith B. , van Herpen Carla M.L.
Published: December 2015

Objective:

It can be assumed that patients' participation in a phase I study will have an important impact on their partners' life. However, evaluation of partners' experiences while patients are undergoing experimental treatment and of their well-being after the patient's death is lacking. We aimed to explore partners' experience of patients' participation in phase I studies and to investigate their well-being after a patient's death.

Method:

This was an observational study conducted after the patient's death. Partners of deceased patients who had participated in a phase I study completed a questionnaire designed by us for experience evaluation and the Beck Depression Inventory for Primary Care, the Hospital Anxiety and Depression Scale, the Inventory of Traumatic Grief, and the RAND-36 Health Survey.

Results:

The median age of the 58 participating partners was 58 years (range: 51–65), and 67% was female. Partners reported negative effects on patients' quality of life, but only 5% of partners regretted patients' participation. Approximately two years after the patients' death, 19% of partners scored for depression, 36% for psychological distress, and 46% for complicated grief, and partners generally scored significantly lower on social and mental functioning compared to normative comparators.

Significance of Results:

Although partners reported negative consequences on patients' quality of life, most did not regret patients' participation in the phase I studies. Prevalence of depression, psychological distress, and complicated grief seemed important problems after a patient's death, and these must be considered when shaping further support for partners of patients participating in phase I trials.
Nucleoprotein of influenza A virus negatively impacts antiapoptotic protein API5 to enhance E2F1-dependent apoptosis and virus replication
Authors: Mayank A K , Sharma S , Nailwal H , Lal S K
Published: December 2015

Apoptosis of host cells profoundly influences virus propagation and dissemination, events that are integral to influenza A virus (IAV) pathogenesis. The trigger for activation of apoptosis is regulated by an intricate interplay between cellular and viral proteins, with a strong bearing on IAV replication. Though the knowledge of viral proteins and mechanisms employed by IAV to induce apoptosis has advanced considerably of late, we know relatively little about the repertoire of host factors targeted by viral proteins. Thus, identification of cellular proteins that are hijacked by the virus will help us not only to understand the molecular underpinnings of IAV-induced apoptosis, but also to design future antiviral therapies. Here we show that the nucleoprotein (NP) of IAV directly interacts with and suppresses the expression of API5, a host antiapoptotic protein that antagonizes E2F1-dependent apoptosis. siRNA-mediated depletion of API5, in NP-overexpressed as well as IAV-infected cells, leads to upregulation of apoptotic protease activating factor 1 (APAF1), a downstream modulator of E2F1-mediated apoptosis, and cleavage of caspases 9 and 3, although a reciprocal pattern of these events was observed on ectopic overexpression of API5. In concordance with these observations, annexin V and 7AAD staining assays exhibit downregulation of early and late apoptosis in IAV-infected or NP-transfected cells on overexpression of API5. Most significantly, while overexpression of API5 decreases viral titers, cellular NP protein as well as mRNA levels in IAV-infected A549 cells, silencing of API5 expression causes a steep rise in the same parameters. From the data reported in this manuscript, we propose a proapoptotic role for NP in IAV pathogenesis, whereby it suppresses expression of antiapoptotic factor API5, thus potentiating the E2F1-dependent apoptotic pathway and ensuring viral replication.
TonEBP modulates the protective effect of taurine in ischemia-induced cytotoxicity in cardiomyocytes
Authors: Yang Y J , Han Y Y , Chen K , Zhang Y , Liu X , Li S , Wang K Q , Ge J B , Liu W , Zuo J
Published: December 2015

Taurine, which is found at high concentration in the heart, exerts several protective actions on myocardium. Physically, the high level of taurine in heart is maintained by a taurine transporter (TauT), the expression of which is suppressed under ischemic insult. Although taurine supplementation upregulates TauT expression, elevates the intracellular taurine content and ameliorates the ischemic injury of cardiomyocytes (CMs), little is known about the regulatory mechanisms of taurine governing TauT expression under ischemia. In this study, we describe the TonE (tonicity-responsive element)/TonEBP (TonE-binding protein) pathway involved in the taurine-regulated TauT expression in ischemic CMs. Taurine inhibited the ubiquitin-dependent proteasomal degradation of TonEBP, promoted the translocation of TonEBP into the nucleus, enhanced TauT promoter activity and finally upregulated TauT expression in CMs. In addition, we observed that TonEBP had an anti-apoptotic and anti-oxidative role in CMs under ischemia. Moreover, the protective effects of taurine on myocardial ischemia were TonEBP dependent. Collectively, our findings suggest that TonEBP is a core molecule in the protective mechanism of taurine in CMs under ischemic insult.
Correction: Corrigendum: Rare coding variants and X-linked loci associated with age at menarche
Authors: Lunetta Kathryn L. , Day Felix R. , Sulem Patrick , Ruth Katherine S. , Tung Joyce Y. , Hinds David A. , Esko Tõnu , Elks Cathy E. , Altmaier Elisabeth , He Chunyan , Huffman Jennifer E. , Mihailov Evelin , Porcu Eleonora , Robino Antonietta , Rose Lynda M. , Schick Ursula M. , Stolk Lisette , Teumer Alexander , Thompson Deborah J. , Traglia Michela , Wang Carol A. , Yerges-Armstrong Laura M. , Antoniou Antonis C. , Barbieri Caterina , Coviello Andrea D. , Cucca Francesco , Demerath Ellen W. , Dunning Alison M. , Gandin Ilaria , Grove Megan L. , Gudbjartsson Daniel F. , Hocking Lynne J. , Hofman Albert , Huang Jinyan , Jackson Rebecca D. , Karasik David , Kriebel Jennifer , Lange Ethan M. , Lange Leslie A. , Langenberg Claudia , Li Xin , Luan Jian'an , Mägi Reedik , Morrison Alanna C. , Padmanabhan Sandosh , Pirie Ailith , Polasek Ozren , Porteous David , Reiner Alex P. , Rivadeneira Fernando , Rudan Igor , Sala Cinzia F. , Schlessinger David , Scott Robert A. , Stöckl Doris , Visser Jenny A. , Völker Uwe , Vozzi Diego , Wilson James G. , Zygmunt Marek , Boerwinkle Eric , Buring Julie E. , Crisponi Laura , Easton Douglas F. , Hayward Caroline , Hu Frank B. , Liu Simin , Metspalu Andres , Pennell Craig E. , Ridker Paul M. , Strauch Konstantin , Streeten Elizabeth A. , Toniolo Daniela , Uitterlinden André G. , Ulivi Sheila , Völzke Henry , Wareham Nicholas J. , Wellons Melissa , Franceschini Nora , Chasman Daniel I. , Thorsteinsdottir Unnur , Murray Anna , Stefansson Kari , Murabito Joanne M. , Ong Ken K. , Perry John R. B.
Published: December 2015

Nature Communications 6, Article number: 7756 (2015); Published 4 August 2015; Updated 17 December 2015 In the Results section and in the legend of Table 1 of this Article, the company deCODE genetics, Inc. is incorrectly referred to as ‘Diabetes Epidemiology: collaborative analysis of Diagnostic criteria in Europe’.
Predicting the impact of promoter variability on regulatory outputs
Authors: Kreamer Naomi N. , Phillips Rob , Newman Dianne K. , Boedicker James Q.
Published: December 2015

The increased availability of whole genome sequences calls for quantitative models of global gene expression, yet predicting gene expression patterns directly from genome sequence remains a challenge. We examine the contributions of an individual regulator, the ferrous iron-responsive regulatory element, BqsR, on global patterns of gene expression in Pseudomonas aeruginosa. The position weight matrix (PWM) derived for BqsR uncovered hundreds of likely binding sites throughout the genome. Only a subset of these potential binding sites had a regulatory consequence, suggesting that BqsR/DNA interactions were not captured within the PWM or that the broader regulatory context at each promoter played a greater role in setting promoter outputs. The architecture of the BqsR operator was systematically varied to understand how binding site parameters influence expression. We found that BqsR operator affinity was predicted by the PWM well. At many promoters the surrounding regulatory context, including overlapping operators of BqsR or the presence of RhlR binding sites, were influential in setting promoter outputs. These results indicate more comprehensive models that include local regulatory contexts are needed to develop a predictive understanding of global regulatory outputs.
Observation of an atomic exchange bias effect in DyCo4 film
Authors: Chen Kai , Lott Dieter , Radu Florin , Choueikani Fadi , Otero Edwige , Ohresser Philippe
Published: December 2015

The fundamental important and technologically widely employed exchange bias effect occurs in general in bilayers of magnetic thin films consisting of antiferromagnetic and ferromagnetic layers where the hard magnetization behavior of an antiferromagnetic thin film causes a shift in the magnetization curve of a soft ferromagnetic film. The minimization of the single magnetic grain size to increase the storage density and the subsequent demand for magnetic materials with very high magnetic anisotropy requires a system with high HEB. Here we report an extremely high HEB of 4 Tesla observed in a single amorphous DyCo4 film close to room temperature. The origin of the exchange bias can be associated with the variation of the magnetic behavior from the surface towards the bulk part of the film revealed by X-ray absorption spectroscopy and X-ray magnetic circular dichroism techniques utilizing the bulk sensitive transmission and the surface sensitive total electron yield modes. The competition between the atomic exchange coupling in the single film and the Zeeman interaction lead to an intrinsic exchanged coupled system and the so far highest exchange bias effect HEB = 4 Tesla reported in a single film, which is accommodated by a partial domain wall formation.
Radionuclide Gas Transport through Nuclear Explosion-Generated Fracture Networks
Authors: Jordan Amy B. , Stauffer Philip H. , Knight Earl E. , Rougier Esteban , Anderson Dale N.
Published: December 2015

Underground nuclear weapon testing produces radionuclide gases which may seep to the surface. Barometric pumping of gas through explosion-fractured rock is investigated using a new sequentially-coupled hydrodynamic rock damage/gas transport model. Fracture networks are produced for two rock types (granite and tuff) and three depths of burial. The fracture networks are integrated into a flow and transport numerical model driven by surface pressure signals of differing amplitude and variability. There are major differences between predictions using a realistic fracture network and prior results that used a simplified geometry. Matrix porosity and maximum fracture aperture have the greatest impact on gas breakthrough time and window of opportunity for detection, with different effects between granite and tuff simulations highlighting the importance of accurately simulating the fracture network. In particular, maximum fracture aperture has an opposite effect on tuff and granite, due to different damage patterns and their effect on the barometric pumping process. From stochastic simulations using randomly generated hydrogeologic parameters, normalized detection curves are presented to show differences in optimal sampling time for granite and tuff simulations. Seasonal and location-based effects on breakthrough, which occur due to differences in barometric forcing, are stronger where the barometric signal is highly variable.
A protein polymerization cascade mediates toxicity of non-pathological human huntingtin in yeast
Authors: Serpionov Genrikh V. , Alexandrov Alexander I. , Antonenko Yuri N. , Ter-Avanesyan Michael D.
Published: December 2015

Several neurodegenerative amyloidoses, including Huntington disease, are caused by expansion of polyglutamine (polyQ) stretches in otherwise unrelated proteins. In a yeast model, an N-terminal fragment of mutant huntingtin with a stretch of 103 glutamine residues aggregates and causes toxicity, while its non-toxic wild type variant with a sequence of 25 glutamines (Htt25Q) does not aggregate. Here, we observed that non-toxic polymers of various proteins with glutamine-rich domains could seed polymerization of Htt25Q, which caused toxicity by seeding polymerization of the glutamine/asparagine-rich Sup35 protein thus depleting the soluble pools of this protein and its interacting partner, Sup45. Importantly, only polymers of Htt25Q, but not of the initial benign polymers, induced Sup35 polymerization, indicating an intermediary role of Htt25Q in cross-seeding Sup35 polymerization. These data provide a novel insight into interactions between amyloidogenic proteins and suggest a possible role for these interactions in the pathogenesis of Huntington and other polyQ diseases.
Secreted multifunctional Glyceraldehyde-3-phosphate dehydrogenase sequesters lactoferrin and iron into cells via a non-canonical pathway
Authors: Chauhan Anoop S. , Rawat Pooja , Malhotra Himanshu , Sheokand Navdeep , Kumar Manoj , Patidar Anil , Chaudhary Surbhi , Jakhar Priyanka , Raje Chaaya I. , Raje Manoj
Published: December 2015

Lactoferrin is a crucial nutritionally important pleiotropic molecule and iron an essential trace metal for all life. The current paradigm is that living organisms have evolved specific membrane anchored receptors along with iron carrier molecules for regulated absorption, transport, storage and mobilization of these vital nutrients. We present evidence for the existence of non-canonical pathway whereby cells actively forage these vital resources from beyond their physical boundaries, by secreting the multifunctional housekeeping enzyme Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) into the extracellular milieu. This effect’s an autocrine/paracrine acquisition of target ligand into the cell. Internalization by this route is extensively favoured even by cells that express surface receptors for lactoferrin and involves urokinase plasminogen activator receptor (uPAR). We also demonstrate the operation of this phenomenon during inflammation, as an arm of the innate immune response where lactoferrin denies iron to invading microorganisms by chelating it and then itself being sequestered into surrounding host cells by GAPDH.
Self-immunity microcapsules for corrosion protection of steel bar in reinforced concrete
Authors: Wang Yanshuai , Fang Guohao , Ding Weijian , Han Ningxu , Xing Feng , Dong Biqin
Published: December 2015

A novel microcapsule-based self-immunity system for reinforced concrete is proposed. Its feasibility for hindering the corrosion of steel rebar by means of lifting the threshold value of [Cl−]/[OH−] is discussed. Precisely controlled release behavior enables corrosion protection in the case of depassivation. The release process is characterized over a designated range of pH values and its release characteristics of the microcapsules, triggered by decreasing pH value, are captured by observing that the core crystals are released when exposed to a signal (stimulus). The aim of corrosion protection of steel bar is achieved through the constantly-stabilized passive film and its stability is promoted using continuous calcium hydroxide released from the microcapsule, restoring alkaline conditions. The test results exhibited that the release process of the microcapsules is a function of time. Moreover, the release rate of core materials could interact with environmental pH value, in which the release rate is found to increase remarkably with decreasing pH value, but is inhibited by high pH levels.
Measurement of the Nucleus Area and Nucleus/Cytoplasm and Mitochondria/Nucleus Ratios in Human Colon Tissues by Dual-Colour Two-Photon Microscopy Imaging
Authors: Su Lim Chang , Sun Kim Eun , Yeon Kim Ji , Taek Hong Seung , Jai Chun Hoon , Eun Kang Dong , Rae Cho Bong
Published: December 2015

We developed two-photon (TP) probes for DNA (ABI-Nu), cytoplasm (Pyr-CT) and mitochondria (BF-MT). We found that ABI-Nu binds to AT in the minor groove, while ABI-Nu and BF-MT are effective for tracking in the cytoplasm and mitochondria, respectively. These probes showed very large effective two-photon action cross section values of 2230, 1555 and 790 Göppert-Mayer units (1 GM  =  10−50 cm4 s photon−1molecule−1) at 740 nm with emission maxima at 473, 561 and 560 nm, respectively, in each organelle. Using these probes, we quantitatively estimated the mean nuclear area and the ratios of nuclei to cytoplasm and mitochondria to nuclei in human colon tissues by dual-colour two-photon microscopy imaging within 2  h after biopsy. The mean nuclear area and the nuclei to cytoplasm and mitochondria to cytoplasm ratios increased in the following order: normal colon mucosa <colon adenoma <colon adenocarcinoma. Furthermore, the nuclear areas of these tissues showed significant differences that were well outside of the ranges of experimental errors, indicating the diagnostic potential of this method.
2,4-Toluene diisocyanate detection in liquid and gas environments through electrochemical oxidation in an ionic liquid
Authors: Lin Lu , Rehman Abdul , Chi Xiaowei , Zeng Xiangqun
Published: December 2015

The electrochemical oxidation of 2,4-toluene diisocyanate (2,4-TDI) in an ionic liquid (IL) has been systematically characterized to determine plausible electrochemical and chemical reaction mechanisms and to define the optimal detection methods for such a highly significant analyte.
Oligonucleotide-stabilized fluorescent silver nanoclusters for the specific and sensitive detection of biotin
Authors: Xiong Xiaoli , Tang Yan , Zhao Jingjin , Zhao Shulin
Published: December 2015

A novel biotin fluorescent probe based on oligonucleotide-stabilized silver nanoclusters (DNA-AgNCs) was synthesized by employing a biotinylated cytosine-rich sequence as a synthesized template.
An LC-MS/MS method to determine PABA and DIP
Authors: Yin Lei , Yang Junfeng , Meng Xiangjun , Yang Bo , Su Chong , Yang Zhichao , Zheng Mi , Zhao Limei , Gu Jingkai , Xin Guijie
Published: December 2015

A liquid chromatography-tandem mass spectrometric method using electrospray ionization for the simultaneous quantitation of p-acetaminobenzoic acid and N,N-dimethylamino-2-propanol in human plasma.
A careful look at traceability in chemical measurement
Authors: Thompson Michael
Published: December 2015

The standard idea of a traceable analytical result is called into question.
The comparison between reproducibility standard deviations from collaborative trials and proficiency tests: a preliminary study from food analysis
Authors: Thompson Michael
Published: December 2015

Reproducibility standard deviations from collaborative trials and from proficiency tests in the food analysis sector are compared and found to be closely similar over a wide range of mass fractions.
Radical C–H functionalization to construct heterocyclic compounds
Authors: Yu Jin-Tao , Pan Changduo
Published: December 2015

Radical C–H functionalization is a promising and dramatic approach to synthesize heterocyclic compounds with high efficiency and environmental sustainability.
Metal-free arylation of pyrimidines through a photochemical process
Authors: Ruch Jonas , Aubin Ariane , Erbland Guillaume , Fortunato Audrey , Goddard Jean-Philippe
Published: December 2015

The photochemical arylation of pyrimidines and pyrazines proceeds smoothly under moderate UVA irradiation and allows us to obtain high-value biaryl compounds through radical intermediates.
Hyperpolarised organic phosphates as NMR reporters of compartmental pH
Authors: Jensen Pernille Rose , Meier Sebastian
Published: December 2015

When formed in defined cellular compartments from exogenous hyperpolarised13C substrates, metabolites yield correlations of compartmental pH and catalytic activity.
Fluorescent Ag nanoclusters prepared in aqueous poly(acrylic acid-co-maleic acid) solutions: a spectroscopic study of their excited state dynamics, size and local environment
Authors: Dandapat Manika , Mandal Debabrata
Published: December 2015

Stable, fluorescent Ag nanoclusters were prepared in aqueous solutions of Na+ salt of the carboxylate-rich polymer poly(acrylic acid-co-maleic acid) under brief spells of UV irradiation.
The van der Waals interactions in rare-gas dimers: the role of interparticle interactions
Authors: Chen Yu-Ting , Hui Kerwin , Chai Jeng-Da
Published: December 2015

We investigate the potential energy curves of rare-gas dimers with various ranges and strengths of interparticle interactions (nuclear–electron, electron–electron, and nuclear–nuclear interactions).
Electronic structure of the para-benzoquinone radical anion revisited
Authors: Kunitsa Alexander A. , Bravaya Ksenia B.
Published: December 2015

Photoinduced processes in para-benzoquinone anion are studied with multistate multireference perturbation theory: an interplay between autodetachment and internal conversion.
Electrochemistry of layered GaSe and GeS: applications to ORR, OER and HER
Authors: Tan Shu Min , Chua Chun Kiang , Sedmidubský David , Sofer Zdenĕk , Pumera Martin
Published: December 2015

The study of the inherent electrochemistry of layered metal chalcogenides, GaSe and GeS, was performed. In particular, their impact towards the electrochemical sensing of redox probes as well as catalysis of oxygen reduction, oxygen evolution and hydrogen evolution reactions was examined.
Spontaneous polarization of solid CO on water ices and some astrophysical implications
Authors: Rosu-Finsen Alexander , Lasne Jérôme , Cassidy Andrew , McCoustra Martin R. S. , Field David
Published: December 2015

Reflection absorption infrared spectroscopy (RAIRS) is used to show that when 20 monolayer (ML) films of solid CO are laid down on solid water substrates at 20 to 24 K, the films polarize spontaneously.
Transition metal pairs on ceria-promoted, ordered mesoporous alumina as catalysts for the CO2reforming reaction of methane
Authors: Aw M. S. , Dražić G. , Djinović P. , Pintar A.
Published: December 2015

Cobalt and iron clusters dispersed over ordered mesoporous γ-Al2O3enable stable conversion of methane and carbon dioxide to syngas. Tungsten containing catalysts deactivate with TOS. Ceria–zirconia redox promotion is crucial for preventing carbon accumulation.
Halogen-bridged metal–organic frameworks constructed from bipyridinium-based ligand: structures, photochromism and non-destructive readout luminescence switching
Authors: Yang Xiao-Dong , Chen Cheng , Zhang Ya-Jun , Cai Li-Xuan , Tan Bin , Zhang Jie
Published: December 2015

Halogen-bridged photochromic metal–organic frameworks have been reported, and one can exhibit photomodulated luminescence featuring a non-destructive readout capability.
Carbon nanotube-based hybrid hole-transporting material and selective contact for high efficiency perovskite solar cells
Authors: Aitola Kerttu , Sveinbjörnsson Kári , Correa-Baena Juan-Pablo , Kaskela Antti , Abate Antonio , Tian Ying , Johansson Erik M. J. , Grätzel Michael , Kauppinen Esko I. , Hagfeldt Anders , Boschloo Gerrit
Published: December 2015

Hybrid hole-transporting material and selective contact for perovskite solar cells was manufactured by industrially viable materials and methods.
Nanoproducts – what is actually available to European consumers?
Authors: Foss Hansen Steffen , Heggelund Laura Roverskov , Revilla Besora Pau , Mackevica Aiga , Boldrin Alessio , Baun Anders
Published: December 2015

It remains unclear which kinds of nanoproducts are available on the European market, although this information is a prerequisite for any kind of exposure and risk assessment.
Pretreatment of natural organic matter to control biological stability
Authors: Bazri Mahdi , Mohseni Madjid
Published: December 2015

Impacts of UV/H2O2and alum coagulation on NOM molecular weight distribution and subsequent biostability of water were investigated.
Evaluation of laser induced breakdown spectroscopy in view of nickel and vanadium on-line determination in petroleum products
Authors: Trichard F. , Gilon N. , Lienemann C. P. , Baco-Antoniali F.
Published: December 2015

Laser induced breakdown spectroscopy (LIBS) has been evaluated for the purpose of analyzing petroleum products. Optimization in view of on-line LIBS control is presented.
Cell refractive index for cell biology and disease diagnosis: past, present and future
Authors: Liu P. Y. , Chin L. K. , Ser W. , Chen H. F. , Hsieh C.-M. , Lee C.-H. , Sung K.-B. , Ayi T. C. , Yap P. H. , Liedberg B. , Wang K. , Bourouina T. , Leprince-Wang Y.
Published: December 2015

Cell refractive index is an important biophysical parameter, which provides new biological and biomedical insight for disease diagnosis and cell biology.
A convenient ‘NOSE’ approach used towards the synthesis of 6-amino-1,3-dimethyl-5-indolyl-1H-pyrimidine-2,4-dione derivatives catalyzed by nano-Ag
Authors: Das Vijay Kumar , Bharali Pranjal , Konwar Bolin Kumar , Mikkola Jyri-Pekka , Shchukarev Andrey , Thakur Ashim Jyoti
Published: December 2015

Uracil derivatives were synthesized in high yield catalyzed by reusable nano-Ag at 70 °C upon reacting 6-amino-1,3-dimethyluracil and indole derivatives.
A palladium-catalyzed coupling reaction of aryl nonaflates, sulfur dioxide, and hydrazines
Authors: An Yuanyuan , Xia Hongguang , Wu Jie
Published: December 2015

A facile route to synthesise N-aminosulfonamides through a palladium-catalyzed coupling reaction of aryl nonaflates, sulfur dioxide, and hydrazines is reported. This transformation proceeds in the presence of Pd(OAc)2/XantPhos, and TBAB in 1,4-dioxane at 80 °C, leading to the corresponding N-aminosulfonamides in moderate to good yields.
A selective C–H insertion/olefination protocol for the synthesis of α-methylene-γ-butyrolactone natural products
Authors: Lloyd Matthew G. , D'Acunto Mariantonietta , Taylor Richard J. K. , Unsworth William P.
Published: December 2015

A regio- and stereoselective one-pot C–H insertion/olefination protocol has been developed for the late stage installation of α-methylene-γ-butyrolactones into conformationally restricted cyclohexanol-derivatives.
Toughened aromatic poly-(decylene terephthalate) copolyesters with two renewable eugenol-based components via a random copolymerization method
Authors: Hu Keling , Zhao Dongping , Wu Guolin , Ma Jianbiao
Published: December 2015

We synthesized two series of poly-(decylene terephthalate) copolyesters toughened with two renewable eugenol-based components, and the best results belong to PDT80%M120% and PDT80%M220% copolyesters.
Copper-mediated radical alkylarylation of unactivated alkenes with acetonitrile leading to fluorenes and pyrroloindoles
Authors: Chu Xue-Qiang , Xing Zhen-Hua , Meng Hua , Xu Xiao-Ping , Ji Shun-Jun
Published: December 2015

A Cu-mediated/catalyzed selective oxidative dual C–H bond cleavage of an arene and alkylnitrile or acetone is reported. This method provides an alternative method for designing new pharmaceutical frameworks and photoelectronic devices.
Perfect rectifying behavior induced by AA-P2 dopants in armchair silicene nanoribbon devices
Authors: Cheng Caiping , Hu Huifang , Zhang Zhaojin , Zhang Haibo
Published: December 2015

The band structures and electronic transport properties of AA-P2-doped armchair silicene nanoribbons (ASiNRs) were investigated by applying density-functional theory in combination with the non-equilibrium Green’s function method.
Light-induced structural changes during early photo-intermediates of the eubacterial Cl−pump Fulvimarina rhodopsin observed by FTIR difference spectroscopy
Authors: Koua Faisal Hammad Mekky , Kandori Hideki
Published: December 2015

Fulvimarina pelagirhodopsin (FR) is a member of inward eubacterial light-activated Cl−translocating rhodopsins (ClR) that were found recently in marine bacteria.
N
1-(3-Trimethoxysilylpropyl)diethylenetriamine grafted KIT-6 for CO2/N2 selective separation
Authors: Kishor Rupak , Ghoshal Aloke Kumar
Published: December 2015

In the present study N1-(3-trimethoxysilylpropyl)diethylenetriamine was grafted on various ordered and commonly used mesoporous silica namely MCM-41 (2.2 nm), SBA-15 (6.6 nm) and KIT-6 (6.6 nm) in both anhydrous and aqueous conditions for CO2/N2 adsorption.
Assembly of TiO2/graphene with macroporous 3D network framework as an advanced anode material for Li-ion batteries
Authors: Li Fei , Jiang Jianzhong , Wang Xinjing , Liu Fan , Wang Jinzuan , Chen Yanwei , Han Sheng , Lin Hualing
Published: December 2015

Three-dimensional (3D) TiO2–graphene frameworks (TGFs) with macroporous architecture were fabricated through thein situsynthesis of TiO2with the participation of graphene oxide followed by hydrothermal assembly.
Sol–gel-processed (001)-textured BiFeO3 thin films on Pt(111)/Ti/SiO2/Si substrates with PbO seeding nanocrystals
Authors: Sun Wei , Zhou Zhen , Li Jing-Feng
Published: December 2015

Highly (001)-oriented BiFeO3 thin films were grown on Pt(111)/Ti/SiO2/Si substrates with PbO seeding nanocrystals by a layer-by-layer annealing method.
Plasmonic photothermal cancer therapy with gold nanorods/reduced graphene oxide core/shell nanocomposites
Authors: Turcheniuk Kostiantyn , Dumych Tetiana , Bilyy Rostyslav , Turcheniuk Volodymyr , Bouckaert Julie , Vovk Volodymyr , Chopyak Valentyna , Zaitsev Vladimir , Mariot Pascal , Prevarskaya Natasha , Boukherroub Rabah , Szunerits Sabine
Published: December 2015

Gold nanorods (Au NRs) are known for their efficient conversion of photon energy into heat, resulting in hyperthermia and suppression of tumor growths in vitro and in vivo.
Two soluble polymers with lower ionization potentials: doping and thermoelectric properties
Authors: Zhang Qian , Sun Yimeng , Qin Yunke , Xu Wei , Zhu Daoben
Published: December 2015

By means of doping with LiTFSI solution in air, polymer PDTPT-C12 shows a thermoelectric power factor approaching 40 μW m−1 K−2 at 390 K.
A room-temperature CuAlO2hole interfacial layer for efficient and stable planar perovskite solar cells
Authors: Igbari Femi , Li Meng , Hu Yun , Wang Zhao-Kui , Liao Liang-Sheng
Published: December 2015

The fabrication and device parameters of inverted planar heterojunction (PHJ) organic–inorganic lead mixed-halide (CH3NH3PbI3−xClx) perovskite based solar cells (PSCs) using a:CuAlO2as the hole selective buffer layer between the ITO electrode and PEDOT:PSS were demonstrated.
Highly conductive, optically transparent, low work-function hydrogen-doped boron-doped ZnO electrodes for efficient ITO-free polymer solar cells
Authors: Polydorou Ermioni , Soultati Anastasia , Vasilopoulou Maria
Published: December 2015

Here the benefits of hydrogen-doped boron-doped ZnO layers for use as efficient bottom cathode electrodes in polymer solar cells are explored.