bluuebunny/crossref_metadata_2025 huggingface dataset:
A new simple and efficient molecular descriptor for the fast and accurate prediction of log P
Authors: Zeng Xiaojian , Ye Xin , Liu Donghua , Cui Ningyi , Li Xiaopeng , Bao Yufan , Zhou Yecheng
Published: January 2025

The partition coefficient (log P) is a critical parameter that measures the balance between hydrophilicity and lipophilicity of molecules, playing a key role in molecular material design and drug development. Developing accurate, efficient, and computationally simple models for log P prediction is essential for advancing drug discovery and materials science. In this study, we introduce the optimized 3D molecular representation of structures based on electron diffraction descriptor (opt3DM) into machine learning (ML) frameworks, achieving highly accurate log P predictions. By fine-tuning key parameters, the scale factor (sL) and descriptor dimension (Ns), we identified the optimal values of sL = 0.5 and Ns = 500. Among various ML algorithms tested, automatic relevance determination (ARD) regression, Ridge regression, and Bayesian Ridge regression demonstrated superior predictive performance. These optimized models outperformed the OPEn structure-activity/property relationship app (OPERA) model on the M-dataset and also delivered competitive results in the SAMPL6 and SAMPL9 challenges. Our findings not only establish a robust, fast, and precise approach for log P prediction, but also highlight the potential of opt3DM as a powerful tool for molecular representation. This work lays a foundation for broader applications in molecular material design and drug development.
All 3D-printed high-sensitivity adaptive hydrogel strain sensor for accurate plant growth monitoring
Authors: Wang Lina , Wang Wen , Wan Rongtai , Yao Mutian , Chen Wenna , Zhang Liuyu , Xu Jingkun , Liu Ximei , Lu Baoyang
Published: January 2025

Highly sensitive strain sensors are crucial for monitoring subtle plant growth changes and show diverse applications in plant sensing. However, the prevailing integrated fabrication methods for such sensors tend to be costly and complex, impeding their fundamental design and practical usage. Herein, we develop a simple and effective multimaterial all-3D printing technique to manufacture integrated strain sensors with a multilayered structure. Such an all-3D-printed strain sensor exhibits excellent sensing performance enabling precise detection of minor strains in plant growth, including high stretchability (> 300%), high sensitivity (~12.78) with good linearity (0.98), and good long-term stability over 3,000 loading/unloading cycles. We further validate the potential applications of our 3D-printed integrated strain sensor for accurate and continuous monitoring of bamboo growth in both horizontal and vertical directions over 14 days. Our all-3D-printed strain sensor offers a promising avenue for integrated strain sensing systems toward plant growth monitoring.
Calibration-free optical waveguide bending sensor for soft robots
Authors: Zhong Liang , Tian Xiaoqing , Wang Ji-Yong , Wang Jian-Xiang , Nie Zhanguo , Chen Xueyin , Peng Yuxin
Published: January 2025

Soft robots have become increasingly popular due to their compliance, deformability, and adaptability. Soft sensors, particularly bending sensors, play a crucial role in providing essential posture and position information for these robots. However, current soft bending sensors encounter difficulties in accurately measuring joint bending angles and directions under different curvatures. To address these challenges, we propose a novel dual-colored layer structured (DCLS) bending sensor based on the optical soft waveguide. The DCLS sensor is constructed using polydimethylsiloxane (PDMS) as the clear core, with red and blue layers on each side. The sensor’s performance is evaluated through experiments involving bending, compression, and impact conditions. The DCLS bending sensor exhibits excellent calibration-free properties, allowing it to effectively monitor bending angles and directions of joints of varying sizes without requiring any additional calibration. The sensor is successfully integrated into various soft robots, including a fruit sorting robot, a fish-inspired robot, and a hand orthotic exoskeleton robot, showcasing its versatility and potential for different applications.
- COMPARISON BETWEEN FINGERPRINT PATTERNS AND TOTALRIDGE COUNT IN DIABETES MELITUS PATIENTS WITH NORMAL POPULATION IN SLEMAN
Authors: Utami Handayani Dwi
Published: January 2025

Background: The number of people with diabetes mellitus (DM) was increased every year in all countries. Screening tools for early, inexpensive, and non-invasive DM predictors are needed. This research was conducted to see the role of dermatoglyphics in DM. Objective: To see the difference in fingerprint patterns and Total Ridge Count (TRC) in DM patients with normal population. Methods: This cross-sectional study involved 200 subjects consisting of 100 DM patients in Sleman and 100 normal respondents at the Faculty of Medicine, UII, Yogyakarta. Fingerprints are obtained by put the finger into ink stamp then print them on paper. The fingerprint images seen by magnifying glass and the TRC was calculated manually. Results: 200 subjects showed that the most frequent pattern of fingerprints appeared ie loops. Comparison of patterns between DM patients with normal respondents ie, whorl 2.5: 1; loop 1: 1,5; arch 1: 1,25, analyzed with the Mann-Whitney test (p = 0,000). TRC in DM patients was 10,730 with an average of 107 and normal respondents were 15,253 with an average of 152 in the ten fingers. TRC was analyzed using the Mann-Whitney test (p = 0,000). Conclusion: There were significant differences in fingerprint and TRC patterns between DM patients and the normal population (p = 0,000). DM patients found more whorl patterns and fewer TRC  than normal respondents.
Hubungan Kadar Serum Glutamic Pyruvate Transaminase (SGPT) dan Serum Glutamic Oxaloacetic Transaminasi (SGOT) dengan Riwayat Konsumsi Alkohol Pada Etnis Papua
Authors: Azizi Biesta Adri , Nurhantari Yudha , . Suhartini , . Triratnaningsih
Published: January 2025

Tujuan penelitian ini adalah  untuk mengetahui hubungan kadar SGPT dan SGOT dengan riwayat  konsumsi alkohol pada etnis Papua Penelitian ini merupakan penelitian deskriptif analitik untuk mengetahui adanya hubungan antara riwayat konsumsi alkohol dengan kadar SGPT dan SGOT. Desain penelitian ini adalah cross sectional dan melibatkan 29 responden etnis Papua yang berdomisili di Yogyakarta. Sampel adalah darah yang didapatkan dari responden setelah dilakukan anamnesis, untuk diperiksa kadar SGPT dan SGOT. Analisis dilakukan menggunakan uji statistik chi-square dengan uji alternatif, Fisher’s exact test. Dari hasil analisis yang telah dilakukan menggunakan uji statistik chi-square, maka didapatkan bahwa tidak ada hubungan yang signifikan secara statistik (p > 0.05) antara kadar SGPT dan SGOT yang diperiksa dengan riwayat konsumsi alkohol pada etnis Papua. Tidak terdapat perbedaan proporsi yang bermakna antara individu etnis Papua yang memiliki riwayat konsumsi alkohol dan individu etnis Papua yang tidak memiliki riwayat konsumsi alkohol terhadap kadar SGPT dan SGOT, namun memiliki kecenderungan peningkatan kadar SGOT 2.567 kali lebih besar dibandingkan individu yang tidak memiliki riwayat konsumsi alkohol.
Pengaruh Perbedaan Jenis Kelamin dengan Jumlah Densitas Alur Sidik Jari dan White Lines pada Mahasiswa Kedokteran Universitas Udayana Angkatan 2016 – 2018
Authors: Soesilopranoto Leonardo Wiranata , Rustyadi Dudut , Alit Ida Bagus Putu
Published: January 2025

Identifikasi  forensik  atau  identifikasi  personal  merupakan  upaya  yang dilakukan  pihak  penyidik  untuk  menentukan  identitas  dan  ciri-ciri  seseorang termasuk  jenis  kelamin.  Identifikasi  jenis  kelamin  merupakan  langkah  yang penting  untuk  mempersempit  kemungkinan  tersangka  kasus.  Sidik  jari  adalah metode  identifikasi  yang  memiliki  tingkat  keakuratan  yang  paling  tinggi.  Sidik  jari  dapat  memberikan  profil  identifikasi  lain yang  penting  seperti  ras,  golongan  darah,  dan  jenis  kelamin  akan  tetapi membutuhkan  waktu  yang  lama  dan  proses  yang  susah.  Terdapat  metode  yang mudah  dan  cepat  untuk  mengidentifikasi  yaitu  melalui  jumlah  densitas  alur  sidik jari  dan  white  lines.  Kedua  hal  tersebut  dipengaruhi  oleh  banyak  hal seperti  ras,  usia,  indeks  massa  tubuh,  dsb.  Karena  itu  perlu  dilakukan  penelitian lebih  lanjut  untuk  melihat  apakah  terdapat  perbedaan  yang  signifikan  jumlah densitas  alur  sidik  jari  dan  white  lines  antara  kedua  jenis  kelamin  pada  mahasiswa kedokteran  Universitas  Udayana  angkatan  2016-2018.  Penelitian  ini  bersifat observational  analitik,  pengambilan  sampel  penelitian  menggunakan  metode stratified  random  sampling  dan  dilakukan  dalam  sekali  waktu  (cross-sectional). Terdapat  83  sampel  yang  berasal  dari  mahasiswa  Program  Studi  Sarjana Kedokteran  dan  Profesi  Dokter  di  Universitas  Udayana  angkatan  2016-2018. Sidik  jari  diambil  menggunakan  metode  ink,  lalu  diamati  menggunakan  kaca pembesar  untuk  menghitung  densitas  alur  sidik  jari  pada  ruang  hitung  dan  white lines.  Berdasarkan  hasil  analisis,  didapatkan  bahwa  terdapat  perbedaan  yang signifikan rata-rata  jumlah  densitas  alur  sidik  jari  pada  ketiga  ruang  hitung  (p  = 0,001;  p  =  0,001;  p  =  0,0001)  dan  rata-rata  jumlah  white  lines  (p  =  0,029)  antar kedua jenis kelamin pada mahasiwa  Program  Studi  Sarjana  Kedokteran  dan  Profesi  Dokter  di  Universitas Udayana.
CHARACTERISTICS VISUM ET REPERTUM OF LIVE VICTIMS AT BHAYANGKARA POLDA DIY HOSPITAL (2014-2016)
Authors: Eko Andhiriawan , Utami Handayani Dwi , Siswoputro Andy Yok
Published: January 2025

ABSTRAK
Latar Belakang : RS.Bhayangkara POLDA DIY adalah salah satu RS yang melayani pemeriksaan klinis dan membuat laporan visum et repertum.  Di dalamnya terdapat karakteristik yang dapat diamati.
Tujuan : Melihat karakteristik VeR hidup RS. Bhayangkara POLDA DIY 01 Januari 2014-31 Desember 2016
Metode :  Deskriptif retrospektif crossectional dengan metode total sampling.
Hasil dan Pembahasan : Data VeR hidup selama 3 tahun berjumlah 46 dokumen yang terbagi : 10 (2014), 7  (2015), dan 29 (2016). Jenis : 28  perlukaan, 18 susila, 0 psikiatrik. Penyebab luka : 4 fisik, 23 mekanik, dan 1 zat kimia. Usia terbanyak 22-40, paling sedikit 0-5 tahun. Jenis kelamin : 25 lelaki dan 21 perempuan. Derajat luka : 17 (derajat 1), 7 (derajat 2), dan 4 (derajat 3). Derajat 1, derajat luka terbanyak  (70 %). 22-40 tahun,usia terbanyak (40 %).Waktu terbanyak, bulan Februari (11) dan paling sedikit Juli. Wilayah terbanyak, Polda DIY (11). Ditreskrimmum Polda DIY, wilayah paling banyak (30 %). Lelaki, jenis kelamin terbanyak (55 %).
Kesimpulan : Jumlah VeR hidup terbanyak, tahun 2016 (61 %). Jenis terbanyak adalah VeR perlukaan, (65 %). Kekerasan mekanik adalah penyebab luka terbanyak (88 %).
Kata Kunci : Karakteristik, Visum et Repertum Hidup, RS.Bhayangkara POLDA DIY.
TRAUMATIC BRAINSTEM INJURY DUE TO BLUNT FORCE TRAUMA: AN AUTOPSY CASE REPORT
Authors: Wiryaningsih Made Ayu Mira
Published: January 2025

Trauma is the leading cause of morbidity and mortality in patients under 35-years of age and the sixth leading cause of death worldwide, but primary traumatic brainstem injury after blunt force trauma to the head is a rare event. A forensic autopsy was performed on a 35 years old female who was found dead in an apartment building with both her hands and feet tied together and mouth closed with duct tape. External examination showed the victim suffered from blunt force trauma to the head, face, both arms and legs. Internal examination of the body showed hematomas on the scalp, temporal muscles and deep neck muscles and organs, subarachnoid, intraventricular and brainstem haemorrhage and contusion, along with signs of asphyxiation. Trauma to the occipital region of the head not only can cause traumatic brain injury but can also cause trauma to the brainstem as a result from acute hyperflexion of the neck. Haemorrhages and contusions of the brainstem can lead to changes in the respiratory system, depending on the location of the lesions. Cause of death was concluded to be force trauma to the occipital region causing primary brainstem injury with the mechanism of death of asphyxia.
MENGUNGKAP PERISTIWA KEMATIAN KRIMINAL KASUS PEMBEKAPAN PERSPEKTIF MEDIKOLEGAL
Authors: Muthaher Annisa Anwar
Published: January 2025

Death is a definite thing in life that can be identified clinically in a person through observing the changes that occur in the corpse's body. The mechanism of death can be unnatural. In this case, wounds were found in the mouth, a form of mechanical smothering. Smothering can cause death, so it is an important reason to discuss and aims to reveal unnatural injuries and what events occurred. The examination method uses the principles of evidence based medicine. On external examination, bruises were found on the inner lips, both eyes (racoon eyes), left cheek, upper jaw, lower  jaw, abrasions on the lips with teeth prints, and cheeks and several other bodies injuries. The lips, the tips of both fingers and the tips of the toes were bluish in color and bleeding spots were found on both inner eyelids. The conclusion of the external examination of the corpse showed that the wounds were unnatural and there were signs of strong pressure on the mouth and nose area which could cause suffocation and there were signs of cranial base trauma. These wounds were caused by blunt trauma
Key words: Asphyxia, Cranial Base Fracture, smothering
Authors: Doberhol James , Suroto Suroto , Guswanto Bambang Hendriya
Published: January 2025

Penyelesaian sistem persamaan linier atas aljabar max-plus tidak dapat dilakukan seperti halnya pada aljabar linier, dikarenakan struktur aljabarnya hanya semilapangan. Pada artikel ini dibahas penyelesaian sistem persamaan linier atas aljabar max-plus dan rancangan aplikasinya menggunakan visual studio. Penyelesaian sistem persamaan linier tersebut, dilakukan dengan menggunakan matriks selisih serta matriks reduksi yang diperoleh dari matriks koefisien dan matriks konstan sistem persamaan linier. Selanjutnya, proses penentuan penyelesaian ini dituangkan dalam aplikasi menggunakan visual studio. Hasil yang diperoleh adalah prosedur langkah untuk menyelesaikan sistem persamaan linier atas aljabar max-plus yang dituangkan dalam aplikasi menggunakan visual studio
Sosialisasi Peningkatan Pengetahuan, Praktik Pencegahan dan Penanggulangan Covid-19 di Kelurahan Purwokerto Lor
Authors: Wibowo Yudhi , Roestijawati Nendyah , Mulyanto Joko , Krisnansari Diah , Munfiah Siti , Rahman Fadel , Aryadenta Ivory Benaziria , Budiyanto Budiyanto
Published: January 2025

Per tanggal 3 Oktober 2021, pandemi covid-19 telah menyebar ke 219 negara, tercatat 234.551.981 kasus dan 4.796.171 kematian. Di Indonesia tercatat 4.220.206 kasus dan 142.261 kematian. Di Jawa Tengah tercatat 482.353 kasus dan 32.050 kematian. Sedangkan menurut Dinas Kesehatan Kabupaten (DKK) Banyumas, tercatat 34.474 kasus dan 1.920 kasus kematian. Kepatuhan memakai masker 91-100%, namun kepatuhan menjaga jarak hanya 61-75%. Di Kelurahan Purwokerto Lor, sejak pandemi covid-19, tercatat 442 kasus terkonfirmasi dan 19 kematian covid-19, sementara itu kepatuhan memakai masker dan manjaga jarak berstatus merah atau < 60%. Pengetahuan dan sikap masyarakat sangat mempengaruhi kepatuhan terhadap upaya pencegahan dan pengendalian covid-19. Tujuan kegiatan ini adalah meningkatkan pengetahun dan praktik pencegahan dan penangulangan covid-19. Metode dengan penyuluhan, simulasi dan praktik menggunakan masker dan cuci tangan menggunakan hand sanitizer yang benar sesuai ketentuan. Hasil uji Friedman tidak didapatkan perbedaan rerata skor peningkatan pengetahuan sebelum dan setelah penyuluhan, evaluasi 1 dan 2 (p=0,147). Untuk sikap tidak berbeda signifikan secara statistik sebelum penyuluhan dengan setelah penyuluhan, evaluasi 1 dan 2 (p=0,088) dengan uji Repeated Anova. Implikasinya bahwa penyuluhan tetap bermanfaat menginformasikan pengetahuan terkini tentang covid-19. Simpulan bahwa masyarakat perlu diberi informasi terkini dan role model disiplin protokol kesehatan.
Optimalisasi Pengetahuan Orangtua Dalam Pencegahan Infeksi Soil Transmitted Helmiths (STH) Pada Siswa SDN Ciberem, Sumbang, Kabupaten Banyumas
Authors: Sari Octavia Permata , Wisesa Sindhu , Dwianasari Lieza , Harini Ika Murti , Setiawati Setiawati
Published: January 2025

Infeksi kecacingan yang disebabkan oleh Soil Transmitted Helminths (STH) masih menjadi masalah kesehatan pada anak di Indonesia termasuk Desa Ciberem, Kecamatan Sumbang, Kabupaten Banyumas. Kegiatan pengabdian masyarakat dilakukan dengan tujuan untuk meningkatkan pengetahuan orang tua siswa SDN Ciberem mengenai infeksi cacing melalui edukasi kesehatan berupa penyuluhan dan praktik cara mencuci tangan. Kegiatan ini dilakukan di SDN Ciberem yang melibatkan 77 orangtua siswa. Pelaksanaan penyuluhan dan praktik cuci tangan dilakukan oleh dosen dan mahasiswa Fakultas Kedokteran Universitas Jenderal Soedirman dengan fokus materi penyebab, faktor risiko, dan dampak kecacingan pada anak. Pretest dan postest dilakukan untuk mengukur peningkatan pengetahuan setelah dilakukan intervensi penyuluhan. Hasil evaluasi menunjukkan orang tua siswa memiliki tingkat pengetahuan awal yang baik mengenai infeksi cacing dan intervensi penyuluhan meningkatkan pengetahuan orang tua secara signifikan (p=0.0035). Hasil pengabdian ini diharapkan dapat berkontribusi dalam pencapaian target penurunan angka kecacingan di wilayah desa Ciberem.
Upaya Peningkatan Kesehatan Warga Lanjut Usia Melalui Edukasi dan Praktik Pengenalan Gejala dan Rehabilitasi Long Covid-19 di Desa Karang Pucung
Authors: Fatchurohmah Wiwiek , Rahmawati Indah , Mustofa Mustofa , Candrawati Susiana
Published: January 2025

Pandemi Covid-19 telah menghadirkan tantangan berat bagi berbagai kelompok masyarakat, termasuk warga lanjut usia. Long Covid-19 dapat memberikan dampak serius terhadap kualitas hidup mereka. Tujuan kegiatan ini adalah untuk meningkatkan pengetahuan dan keterampilan mengenai pengenalan dan rehabilitasi long Covid-19. Kegiatan edukasi dilaksanakan pada hari Sabtu, tanggal  15 Juli 2023, bertempat di desa Karang Pucung Kecamatan Purwokerto Selatan.. Peserta terdiri atas kader posyandu lansia, pengurus RT, pengurus RW, dan anggota posyandu lansia RW 007 desa Karang Pucung.  Materi pertama membahas mengenai mengenai gejala long covid, gejala penyakit pernafasan yang sering pada lansia, dan bagaimana mengatasinya. Materi kedua mengenai latihan fisik dan mendemokan beberapa gerakan yang dapat menguatkan sistem pernafasan. Edukasi tentang pengenalan gejala dan rehabilitasi Long Covid-19 telah meningkatkan pengetahuan secara signifikan bagi warga lanjut usia di Desa Karang Pucung. Dengan demikian, para lansia menjadi lebih siap menghadapi tantangan kesehatan yang mungkin terjadi dan meminimalkan dampak negatifnya untuk meningkatkan kualitas hidupnya.
Pelatihan Diagnosis Anemia Dan Thalassemia Bagi Dokter Dan Tenaga Teknis Kesehatan Di Wilayah Banyumas
Authors: Rujito Lantip , Siswandari Wahyu , Wahyudin Wahyudin , Lestari Diyah Woro Dwi , Ferine Miko , Sylviningrum Thianti , Suprihatin Suprihatin , Hatmoko Sito
Published: January 2025

Masalah kesehatan Thalassemia di Indonesia, khususnya di Banyumas, telah menjadi perhatian utama karena tingginya prevalensi dan dampak ekonomi yang signifikan. Kabupaten Banyumas, dengan angka carrier Thalassemia yang mencapai 8%, menghadapi tantangan besar dalam pencegahan penyakit ini. Artikel ini membahas pelatihan yang dilakukan untuk meningkatkan kapasitas tenaga kesehatan dalam diagnosis dan pencegahan anemia serta Thalassemia di wilayah Banyumas. Pelatihan ini diikuti oleh tenaga teknis kesehatan dari berbagai Puskesmas dan berhasil meningkatkan pengetahuan serta keterampilan peserta secara signifikan. Selain itu, pelatihan ini juga mendorong terbentuknya jaringan kolaborasi antar Puskesmas yang penting untuk keberhasilan implementasi program pencegahan di masa mendatang. Meskipun demikian, tantangan yang teridentifikasi selama pelatihan, seperti keterbatasan alat dan variasi pemahaman masyarakat, menunjukkan perlunya upaya berkelanjutan dan dukungan dari berbagai pihak. Hasil pelatihan ini menjadi langkah awal yang penting menuju pencapaian target zero Thalassemia mayor di Banyumas pada tahun 2030.
Penguatan Keterampilan Komunikasi Efektif Dokter Dalam Proses Informed Consent Dengan Role Play
Authors: Ferine Miko , Hidayah Arfi Nurul , Amalia Amalia , Lestari Diyah Woro Dwi , Muflikhah Khusnul
Published: January 2025

Jumlah kasus tuntutan hukum terhadap dokter (sengketa medik) di Indonesia semakin meningkat. Proses komunikasi yang kurang efektif dalam memberikan informasi medik memberikan kontribusi besar. Meskipun telah dilaksanakan proses Informed consent, pasien sering mengikuti prosedur medik tertentu tanpa pemahaman yang lengkap dan relevan. Pengabdian kepada masyarakat ini dilaksanakan dengan tujuan untuk meningkatkan kepedulian dokter mengenai pentingnya pemahaman pasien terhadap berbagai prosedur medik yang akan dilaksanakan dan menguatkan keterampilan komunikasi efektif dalam proses informed consent dengan metode role play. Kegiatan ini dilaksanakan dalam bentuk pelatihan yang dilaksanakan melalui kerja sama dengan Ikatan Dokter Indonesia cabang Banyumas. Kegiatan ini diikuti oleh dokter umum di wilayah Banyumas. Kenaikan rerata nilai pre-tes dan post-test menunjukkan hasil yang signifikan. Oleh karena itu dapat disimpulkan bahwa pelatihan dengan metode role play ini bermanfaat bagi para peserta kegiatan.
TINGKAT POSITIVITAS PEMERIKSAAN KALIUM HIDROKSIDA PADA PASIEN OTOMIKOSIS
Authors: Widhi Anriani Puspita Karunia Ning , Krisniawati Nia , Darmawan Anton Budhi , Nur Hestiyani Rani Afifah
Published: January 2025

Otomycosis is an opportunistic fungal infection of the external ear canal and is widespread worldwide. The clinical manifestations of otomycosis are non-specific symptoms such as earache, discharge, itching, hearing loss, feeling of fullness in the ear, and tinnitus. The most common etiology found is Aspergillus sp. and Candida sp. The purpose of this study was to assess the positivity level of KOH examination in patients with a clinical diagnosis of otomycosis. The method used in this research uses a descriptive quantitative approach. The research subjects were otomycosis patients at the ENT-KL clinic at Margono Soekarjo Hospital from April to August 2022. Samples were taken using Flexible minitip flocked sterile swabs (Copan, Italy) on white to black ear secretions. Swabs were isolated on Saboraud Dextrose Agar (SDA) mushroom culture media (Himedia, India) and for KOH examination. The results obtained in this study were 48(85.7%) positive KOH, positive culture and 8(14.3%) negative KOH, positive culture. In a sample of 56 patients with a clinical diagnosis of otomycosis the most common isolates were Aspergillus sp 32 (57.1%) and Candida sp (42.9%). KOH sensitivity and specificity test results for Aspergillus sp were 37.7% and 100%, while for Candida sp were 97.7% and 50%. The conclusion of this study is that the KOH examination has a positivity rate of 85.7%. This examination needs to be routinely carried out as an initial screening to support the clinical diagnosis of otomycosis.
SYSTEMATIC REVIEW: POTENSI ANTI-INFLAMASI PADA TANAMAN PETAI (Parkia speciosa)
Authors: Ati Viva Ratih Bening , Zahra Rafika , Pristika Alya , Hevatio Dufvan , Widodo Azzahra Wuri , Kinanti Luhung Sekar , Munawir Azzah Azizah , Widyasari Ailsya Inaayah Putri
Published: January 2025

Anti-inflammatory is defined as a compound or class of drugs that has the activity of suppressing or reducing the inflammatory response. Inflammation is a dynamic body defense mechanism and can be acute or chronic. There are still many Indonesian people who self-medicate (self-medication) using modern and herbal medicine. One of the native Indonesian plants used as a herbal medicinal plant is petai (Parkia speciosa). One of the known benefits of petai is as an anti-inflammatory because of the flavonoid content in it. The aim of this research is to examine the potential anti-inflammatory activity of the petai plant (Parkia speciosa). This research method was based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). The articles used in this research came from databases such as Google Scholar, Pubmed, Semantic Scholar, Researchgate, Ebsco with the keywords used namely (Parkia speciosa) AND (stink bean) AND (anti-inflammatory). There were 8 articles taken for review. The conclusion is that petai (Parkia speciosa) seed, skin and leaf extracts have anti-inflammatory potential based on in vitro and in vivo tests.
INFEKSI SOIL TRANSMITTED HELMINTHS PADA ANAK USIA SEKOLAH DASAR: PERILAKU JAJAN DAN PERILAKU HIGIENE
Authors: Sari Octavia Permata , Susiawan Lieza Dwianasari , Wisesa Sindhu , Harini Ika Murti , Setiawati Setiawati
Published: January 2025

Soil Transmitted Helminths (STH) are a group of parasitic nematodes that pass through the soil in their life cycle. STH can infect the digestive system and cause harm to humans. One of the risk factors for STH is snacking behavior and poor hygiene behavior in school-aged children. This study aims to determine the relationship between snacking behavior and hygiene behavior with the incidence of STH infection in students at SDN Ciberem, Sumbang District, Banyumas Regency. This research is an analytical observational study with a cross-sectional design and was carried out using purposive sampling. The population of this study were students in grades 1-5 at SDN Ciberem with a sample size of 96 students. Data collection was carried out using questionnaires and fecal examination at the FK Unsoed Parasitology Laboratory using qualitative methods. The data obtained were analyzed using Fisher's Exact Test. In this study, it was found that 5 students (5.2%) were infected with Trichuris trichiura type STH. The Fisher's Exact test showed a significant relationship between STH infection with hand washing habits (p = 0.037), the condition of the snacks being served open (p = 0.026), and lots of flies around the snacks (p = 0.031), but there was no significant relationship with the habit of using footwear (p = 1.000), the habit of cutting nails (p = 0.256), and the frequency of snacks (p = 0.333). There is a significant relationship between the habit of washing hands, buying open snacks and snacks with lots of flies around them and the incidence of STH infection.
Key words: STH, SD, snacking behavior, hygiene behavior, washing hands
HUBUNGAN DUKUNGAN KELUARGA DENGAN KUALITAS HIDUP PADA PASIEN TUBERKULOSIS RESISTAN OBAT
Authors: Virgin Aprilia , Rahmawati Indah , Yuliani Massita Dwi
Published: January 2025

Pengobatan penyakit Tuberkulosis Resistan Obat yang memerlukan konsumsi obat dalam durasi yang panjang, pentingnya dukungan yang baik menjadi suatu kebutuhan. Dukungan dari keluarga menjadi aspek yang sangat penting bagi individu yang mengalami Tuberkulosis Resistan Obat sebagai sumber utama dukungan. Dukungan keluarga sangatlah penting dalam meningkatkan kualitas hidup pasien Tuberkulosis Resistan Obat. Penelitian ini mengidentifikasi hubungan dukungan keluarga dengan kualitas hidup pada pasien Tuberkulosis Resistan Obat. Penelitian ini merupakan observasional analitik dengan rancangan cross-sectional pada populasi terjangkau penderita TB RR (Rifampisin Resistant) dan MDR (Multi Drug Resistant) yang sedang menjalani pengobatan di RSUD Prof. Dr. Margono Soekarjo dan RSUD Ajibarang pada tahun 2022-2023. Sebanyak 32 orang terpilih sebagai responden dengan menggunakan metode consecutive sampling. Kriteria inklusi yang ditetapkan yaitu pasien TB RR dan MDR yang berobat ke RSUD Prof. Dr. Margono Soekarjo dan RSUD Ajibarang pada tahun 2022-2023 serta bersedia menjadi responden penelitian setelah menandatangani informed consent. Kriteria eksklusi meliputi alamat domisili tidak jelas, pasien tidak berada di tempat saat pengambilan data, tidak mengisi kuesioner secara tuntas, tidak kooperatif dalam pelaksanaan penelitian serta pasien dengan komorbid seperti HIV, DM, hipertensi dan PPOK. Analisis data menggunakan uji Non Parametrik dengan metode Spearman. Sebanyak 65,6% subjek memiliki dukungan keluarga yang tinggi, 31,3% memiliki dukungan keluarga yang sedang dan 3,1% subjek memiliki dukungan keluarga yang rendah. Sebanyak 78,1% subjek memiliki kualitas hidup yang baik sedangkan 21,9% subjek memiliki kualitas hidup yang buruk. Hasil uji analisis data menggunakan Spearman mendapatkan hasil nilai significancy sebesar p=0,005 dengan r=0,481 yang menunjukkan hubungan signifikan antara dukungan keluarga dengan kualitas hidup pada pasien Tuberkulosis Resistan Obat dengan arah korelasi positif dan kekuatan korelasi sedang. Disimpulkan bahwa dukungan keluarga berhubungan dengan kualitas hidup pada pasien Tuberkulosis Resistan Obat.
 
Kata Kunci : Dukungan keluarga, kualitas hidup, Tuberkulosis Resistan Obat
PERBANDINGAN KLORAMFENIKOL, ERITROMISIN DAN FORMALIN DENGAN BERBAGAI DOSIS TERHADAP PENGHAMBATAN PERTUMBUHAN Clostridium perfringens
Authors: Peramiarti IDSAP , Syamsu Hidayat Muhammad Zaenuri
Published: January 2025

Kematian adalah berhentinya sistem fungsi jantung atau sirkulasi, sistem pernafasan, dan telah terjadi kematian batang otak. Sesaat setelah terjadi kematian akan terjadi proses pembusukan. Bakteri utama yang berperan dalam proses pembusukan adalah bakteri Clostridium perfringens. Proses pembusukan terkadang perlu dihambat dengan pengawetan jenazah. Pengawetan jenazah adalah tindakan medis  berupa  pemberian  bahan  kimia seperti  formalin atau dapat menggunakan antibiotik spektrum luas bersifat bakteriosidal seperti eritromisin dan kloramfenikol.  Penelitian  ini dilakukan untuk mengetahui kemampuan, eritromisin, kloramfenikol dan formalin dalam menghambat pertumbuhan C. perfringens  serta  menentukan  konsentrasi  senyawa atau antibiotik yang efektif.  Jenis  penelitian  ini adalah  true  eksperimental  dengan  pendekatan  post-test  only with  control  group design. Konsentrasi kloramfenikol yang diberikan dosis 0,25 µg/mL, 0,5 µg/mL, 1 µg/mL, 2 µg/mL, dan 4 µg/mL; eritromisin dosis 0,2  µg/mL,  0,4  µg/mL,  0,8 µg/mL, 1,6 µg/mL, dan 3,2 µg/mL; formalin sebesar 2%,4%,6%,8%, dan 10%  dalam  medium Nutrient Broth. Dilakukan inkubasi 24 jam dengan suhu 37OC, lalu  penanaman  di  medium  agar  cawan  dengan  metode  spread   plate   untuk mengetahui pertumbuhan bakteri. Bakteri yang tumbuh kemudian dihitung dengan colony counter  dan  dilakukan  perhitungan  presentase  penghambatan.  Data yang diperoleh diuji menggunakan uji parametrik One Way Annova dan dilanjut dengan Post Hoc Test. Konsentrasi senyawa efektif dilihat berdasarkan Minimum Inhibitory Concentration  50 (MIC50). Hasil penelitian ini menunjukkan bahwa jumlah koloni sangat dipengaruhi oleh jenis senyawa karena p = 0,009 (p<0,05), dan hasil Post Hoc Test konsentrasi formalin 10% dan 8%  memiliki jumlah koloni paling rendah atau mempunyai kemampuan menghambat pertumbuhan C. perfringens bakteri paling besar sebesar 80% dan 63%,  sehingga dapat dikatakan sebagai konsentrasi efektif (MIC50) pada perlakuan formalin 8% dengan penghambatan pertumbuhan sebesar 63%.
Geometric Analysis of Voids in the FRW Spacetime
Authors: Laforet Christopher
Published: January 2025

We show that the cosmological model of the Universe can be described as an FRW Universe interspersed with spherical voids described by the interior Schwarzschild metric. The voids cannot be described using the Minkowski metric because the Universe has a past horizon (the Big Bang) and given that the Minkowski metric has no such horizon, we conclude that the geometry of the voids must be described by the interior Schwarzschild metric. The model is compared to observational cosmological data and is shown to fit observation as an explanation of the accelerated expansion of our Universe without the need for a Cosmological constant.
High-Power Ultrafast Radially and Azimuthally Polarized Accelerating Airy Beams and their Particle-Like Topologies
Authors: Berškys Justas , Šlevas Paulius , Orlov Sergej
Published: January 2025

Accelerating Airy beams, known for their non-diffracting nature, self-healing properties, and curved propagation trajectories, are solutions to the paraxial wave equation. In this work, we theoretically and experimentally investigate nonuniform (radially and azimuthally) polarized vector Airy beams. We provide an analytical representation of their spatial spectra and examine their electromagnetic field distributions in space. To validate the theoretical model, we have used a nanograting inscribed inside a glass volume by a femtosecond laser to create geometrical phase elements, suitable for the realization of high-power ultrafast radially and azimuthally polarized vector Airy beams. We have conducted experiments that confirm the successful generation of high-power vector beams and have performed Stokes parameter measurements of these beams. Additionally, we explore both theoretically and experimentally their topology, identifying particle-like formations such as skyrmionic and antiskyrmionc accelerating lattices within the high-power ultrafast electric fields and their Stokes parameters.
Replication and Characterization of the Causally Ambiguous Duration-Sorting (CADS) Effect
Authors: Mossbridge Julia
Published: January 2025

It is generally assumed that information about the exact nature of truly random events can only be obtained after those events occur. One empirical apparent contradiction of this assumption is the causally ambiguous duration-sorting (CADS) effect, in which photon absorptions are measured before a truly random decision about the duration of an experiment is made. The only parameter varied across experimental runs is the duration between on- and off-times, yet the number of photons absorbed prior to this decision is related to the decision itself. This report focuses on further examining the CADS effect by characterizing the pre-decision periods for data continuously recorded for 365 days in an independent laboratory using upgraded equipment. A complex but reliable periodicity gave a conservative estimate of 4.7 for sigma, and a linear CADS equation emerged to estimate magnitude at peak frequencies for each of four equiprobable post-decision durations. An apparently novel relationship between photon absorptions and lunar phase was also found. Determining whether accurate pre-decision information about future durations is only available in retrospect requires further experimentation, but these results strongly support apparent retrocausality or at least causal ambiguity in groups of photons with shared classical boundaries in time.
Prognostic Factors of Postoperative Mortality in Patients with Complicated Right Colon Cancer
Authors: Mihailov Raul , Dima Corina , Constantin Georgiana Bianca , Dimofte Florentin , Crăescu Mihaela , Moroianu Lavinia Alexandra , Candussi Iuliana-Laura , Lutenco Verginia , Mihailov Oana Mariana , Lutenco Valerii
Published: January 2025

The incidence of right colon cancer presented in the stage of complications is significant. There are major differences in therapeutic approach between elective colon cancer surgery and emergency surgery. Complications such as hemorrhage, obstruction, and perforation require careful evaluation of prognostic factors, with morbidity and mortality rates being much higher compared to elective colon surgery.
We retrospectively analyzed a group of 95 patients admitted in emergency in the County Emergency Hospital St. Apostol Apostol Andrei Galati with complicated tumors of the right colon - occlusive, perforated or hemorrhagic. A series of clinical and biological parameters were followed in order to identify prognostic factors in the occurrence of death.
We analyzed the specialized literature, comparing our study with other similar research from the most important databases.
The postoperative death rate in patients with complicated right colon cancer is high. Most complications were occlusive, followed by hemorrhagic and perforative complications.
A Novel Standard or Evolution in Treatment? A Systematic Review with Insights from Single-Center Experience on Robot-Assisted Urachal Excision and Partial Cystectomy for Urachal Pathologies
Authors: Drobot Rafał Bogdan , Stawarz Grzegorz , Lipa Marcin , Antoniewicz Artur Andrzej
Published: January 2025

Background: Ura-chal pathologies, while rare, pose a malignant transformation risk. RAUEPC is a mini-mally invasive technique with potential benefits, yet evidence remains limited. Methods: A systematic review was conducted in PubMed, Scopus, the Cochrane Library, and Sci-enceDirect (last search: 1 November 2024). Inclusion criteria: studies on RAUEPC for ura-chal pathologies. Exclusion criteria: non-robotic approaches or incomplete data. Risk of bias was assessed using the Newcastle-Ottawa Scale for cohort studies and the JBI Critical Appraisal Checklist for case reports. Descriptive statistics summarized continuous data (means, medians, 95% CIs), and chi-square tests analyzed associations between categori-cal variables. Heterogeneity analysis was infeasible, necessitating narrative synthesis. In-stitutional data (3 cases, 2021–2024) were included for comparison. Results: Forty-four studies (n = 145) met inclusion criteria. Benign lesions constituted 66.2% (95% CI: 59.1–73.3%) and malignant lesions 33.8% (95% CI: 26.7–40.9%). Mean operative time was 177.8 min (95% CI: 96.8–300), blood loss 83.3 mL (95% CI: 50–171), and hospital stay 3.9 days (95% CI: 1–10.9). Complications occurred in 33.3%. Institutional results showed a mean operative time of 85.3 min, blood loss of 216.7 mL, and no recurrences at 10.7 months’ fol-low-up. Discussion: RAUEPC appears to be a feasible and safe approach, showing prom-ising short-term outcomes. Associations between symptoms and diagnostic methods sug-gest its utility. Limitations include small sample sizes and retrospective designs. Registra-tion: PROSPERO: CRD42024597785. Funding: No external funding.
Religion And Violence In Romania: The Impact Of Secularization On Interreligious Conflicts
Authors: Tanase Laurentiu , Dascalu Cezar
Published: January 2025

The analysis examines the trajectories of violence among religious groups in Romania, focusing on conflicts between Orthodox and Greek Catholic communities and between Orthodox and neo-Protestant communities. Forms of verbal, psychological, physical, and spiritual violence were tracked based on definitions provided by Romanian legislation. The research hypothesis posits that the intensification of secularization and anticlericalism has contributed to the reduction of violence between Orthodox and Greek Catholic/neo-Protestant communities in Romania from 1990 to 2023.In Orthodox-Greek Catholic conflicts, the central issue is patrimonial, while tensions between Orthodox and neo-Protestant communities stem primarily from proselytism and the migration of believers. Notable reductions in violence are observed, particularly after 2007, when secularization and anticlericalism became common adversaries for religious groups. The study analyzed all U.S. Department of State Reports on Religious Freedom in Romania, reports by the State Secretariat for Religious Affairs, Synodal reports of the Romanian Orthodox Church, all issues of Vestitorul Ortodoxiei and Biserica Ortodoxă Română[1], as well as 112 articles on religious conflicts from local and national media from 1990 to 2023. Numerous semi-structured interviews were conducted with Baptist, Adventist and Pentecostal pastors, between October 2023 and March 2024.
Kidney Toxicity of the Drugs for the Heart. An Updated Perspective
Authors: Caiati Carlo , Arrigoni Roberto , Stanca Alessandro , Lepera Mario Erminio
Published: January 2025

Cardiovascular drugs are widely used for the prevention and treatment of various cardiac and vascular disorders. However, some of these drugs can also cause adverse effects on the kidney, leading to acute or chronic renal dysfunction, electrolyte imbalances, and increased mortality. The mechanisms of drug-induced renal toxicity vary depending on the type and class of the drug, the dose and duration of exposure, and the patient’s characteristics and comorbidities. In this review, we summarize the current knowledge on the renal effects of some common cardiovascular drugs, such as diuretics, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, calcium channel blockers, beta-blockers, antiplatelet agents, anticoagulants, and statins and proton-pump inhibitors. We also discuss the clinical implications and management strategies for preventing or minimizing drug-induced nephrotoxicity, as well as the potential role of oxidative stress in its pathogenesis.
Establishment of Agrobacterium-mediated Transient Transformation System in Sunflower
Authors: Chen Fangyuan , Huang Qixiu , Jiang Run , Li Wenhui , Xiao Lvting , Hou Xianfei , Xiang Lijun , Li Qiang , Lei Zhonghua , Zeng Youling
Published: January 2025

ZADT is a significant oil sunflower variety in Northwest China, renowned for its robust resistance to salt and drought. However, the lack of an optimal genetic transformation system has greatly hindered the elucidation of its superior traits and the advancement of molecular breeding in sunflowers. Establishing a straightforward and efficient transient transformation system could effectively address these limitations. We utilized Agrobacterium tumefaciens to transform the backbone parent ZADT retention line. The sunflower transient expression system was successfully established and optimized using infiltration, injection, and ultrasound-vacuum methods. Among these methods, an Agrobacterium growth concentration of OD600 0.8 and the surfactant Silwet-77 favored transient transformation. In the infiltration method, the highest transformation efficiency was achieved after 2 hours of infiltration. For the injection method, the optimal conditions were determined to be when seedlings were grown for 4-6 days and kept in dark culture for 3 days. The ultrasound-vacuum method was most effective with 40 kHz ultrasound for 1 minute followed by 0.05 kPa vacuum filtration for 5-10 minutes. Gene expression in the sunflower transient system was maintained for at least 1 week using all three methods. Additionally, the infiltration method was applied to preliminarily identify the salt tolerance function of the genes HaMYB108 and HaWRKY40 in sunflower. A highly efficient transient transformation platform for Agrobacterium-mediated ZADT was successfully established using three distinct methods. This platform was subsequently employed to preliminarily confirm the functions of the candidate gene. It offers significant support for conducting molecular biology studies such as gene function analysis, subcellular localization, gene interactions, and ChIP-seq.
Optimizing Customer Experience by Exploiting Real-Time Data Generated by IoT and Leveraging Distributed Web Systems in CRM Systems
Authors: Ileana Marian , Petrov Pavel , Milev Vassil
Published: January 2025

Integrating smart devices from the Internet of Things (IoT) with Customer Relationship Management (CRM) systems presents significant opportunities for enhancing customer experience through real-time data utilization. This article examines how data generated by IoT devices, when processed and shared across Distributed Web Systems, enables CRM platforms to improve both responsiveness and personalization. By continuously analyzing real-time information about customer interactions, behaviors, and preferences, companies can adapt their offerings to meet individual needs proactively, delivering highly customized services that anticipate and satisfy customer demands. The study provides a detailed framework for integrating IoT data within CRM systems, focusing on the technological architecture necessary for seamless data flow, improved system scalability, and efficient data management. Furthermore, it highlights the critical role of distributed computing in enabling the processing power required for managing large-scale data from IoT devices. This paper also addresses various challenges, such as data security concerns, the complexity of system integration, and the demand for real-time analytics, offering practical solutions and innovative strategies to overcome these obstacles and fully leverage IoT data for optimizing customer relationships.
MaaS Personalised Multi-Modal Multi-Objective Journey Planning with Machine Learning Guided Shortest Path Algorithms
Authors: Bayliss Christopher , Ouelhadj Djamila , Dadashzadeh Nima , Fletcher Graham
Published: January 2025

This work presents a methodology for rapidly generating many multi-modal journey alternatives including cheap, fast, green, convenient and low effort alternatives to private car journeys. The proposed methodology firstly generates a Pareto set of journey profiles based on static inter-transfer zone objective criteria contribution estimates. Secondly, integrated and extended versions of existing shortest path algorithms for open and public transport networks are used to optimise paths and transfer points in a procedure guided by neural networks while using real-time transport network information. A novel hybrid k-means and Dijkstra’s algorithm is introduced for generating transfer zone samples, in a way that accounts for transport network connectivity to ensure transfer feasibility. The end result is a modularised algorithm that knits together and extends the most effective existing shortest path algorithms for open and public transport networks using neural networks as a look ahead mechanism for generating many efficient multi-modal journey alternatives. In experiments based on a large scale transport network, query response times are shown to be suitable for real-time applications, and are found to be independent of transfer zone sample size, despite larger transfer zone samples leading to higher quality and more diverse Pareto sets of journeys, a win-win scenario.
Differential Gene Expression in the Prefrontal Cortex and Hippocampus Following Long-Access Methamphetamine Self-Administration in Male Rats
Authors: Robison Christopher L , Madore Victoria , Cova Nicole , Karbalivand Mona , Elsawa Sherine F , Charntikov Sergios
Published: January 2025

Methamphetamine (METH) is a potent psychostimulant that disrupts cognitive and neurobiological functions in brain regions such as the prefrontal cortex (PFC) and hippocampus. Chronic METH use leads to altered synaptic plasticity, neuroinflammation, and mitochondrial dysfunction, contributing to methamphetamine use disorder (MUD). This study investigates gene expression changes following long-access intravenous METH self-administration in a rodent model. RNA sequencing (RNA-Seq) was conducted on PFC and hippocampal tissue to identify differentially expressed genes (DEGs) between METH-treated and control groups. We identified 41 DEGs in the PFC and 32 in the hippocampus, many involved in synaptic plasticity, immune response, and energy metabolism. Key findings included downregulation of mitochondrial function genes and upregulation of genes related to neural development and extracellular matrix organization, highlighting the profound transcriptional effects of METH. As a proof-of-concept, we explored individual gene expression variability in relation to economic demand for METH. Rats exhibiting higher demand showed distinct molecular profiles, including upregulation of genes linked to neural signaling and transcription regulation, such as Foxd1 and Cdh1. This preliminary analysis demonstrates that individual differences in drug-seeking correlate with unique gene expression patterns. These findings suggest that both group-level and individual molecular changes contribute to the neurobiological mechanisms of METH use. A better understanding of these individual differences could potentially inform the development of personalized therapeutic approaches for MUD.