bluuebunny/crossref_metadata_2025 huggingface dataset:
effective role of vitamin D and omega-3 on rats with induced Crohn’s disease
Authors: Rabeh Naeem M. , Ibrahim Hoda S. , Osman Fatma N.
Published: July 2022

Crohn's disease is an irreversible inflammatory disease, mainly affecting the gastrointestinal tract. The aim of present study was to investigate the effect of dietary vitamin D and omega 3 supplementation on rats with induced Crohn’s disease. Twenty – four adult male albino rats weighing (160 gm) were divided into 4 groups. The 1st group (n=6) was fed on the basal diet. The 2nd to 4th of rats (n=18) were injected with (10 mg/kg for 3 days) of indomethacin at the end of the experiment to induce Crohn’s disease. Groups (3 and 4) were fed on basal diet and given orally 1000/IU/kg/ b.w. of vitamin D and 600 mg/kg/b.w. of omega 3 respectively. At the end of the experimental period (8 weeks), rats were scarified. Biochemical analysis of the tested parameters was determined. The Results indicated that indomethacin Crohn’s rats showed a significant (P< 0.05) decrease in serum albumin, serum Catalase and serum Glutathione peroxidase compared to the negative control one, while serum liver function, MDA, CRP, and immunity proteins were significantly increased.
Muscle dystrophies in children
Authors: Elgamal Aya Mohamed Elsayed , Girgis Marian Yousry Fahmy , Hashim Rania Hamdy , Afify Omneya Gamal Eldin , Elnaggar Walaa Mohamed Hassen
Published: July 2022

Muscular dystrophies are a heterogeneous inherited group of disorders characterized by a variable distribution of weakness, various ages of onset, the pattern of inheritance, rate of progression, and clinical severity. Muscle degeneration and regeneration characterize muscle biopsy and these disorders are typically associated with elevated serum creatine kinase. Objective: We wanted to study the clinical characteristics of patients with muscle dystrophies and study clinical and genetic correlation in patients with Duchenne muscular dystrophy. Methods: This cross-sectional descriptive study included a cohort of 60 patients diagnosed with muscular dystrophy and fulfilling the inclusion criteria. All patients were subjected to full history taking and full neurological examination. Results: Patients are divided into five groups to study clinical characteristics in each group. 1. Duchenne muscular dystrophy group: included 30 patients who have genetically confirmed DMD cases (50 %), 2. Limb-girdle muscular dystrophy group: included 23 patients (38.3 %), 3. Myotonic dystrophy group: included 3 patients (5 %), 4. Congenital muscular dystrophy group: included 3 patients who were diagnosed clinically as merosin deficient congenital muscle dystrophy (5 %), 5. Distal dystrophy group: included 1 patient with distal muscle dystrophy (1.7 %). Mean age, gender, age of symptoms onset, main motor symptoms, CPK level, echocardiography.
Study of infection intensity of Copepods parasites from the genus (Ergasilus) on gills of carp fishes (Cyprinus carpio L) (endoparasites), and on fish's tail region (exoparasites) for big sizes and small sizes (Fingerlings) at three seasons (summer, winte
Authors: Arif Saad M. , Sheriff Hussain A.
Published: July 2022

This study was conducted to determine the infection intensity of Copepods parasites from the genus (Ergasilus) on gills of carp fishes (Cyprinus carpio L.)   (endoparasites), and on fish's tail region (exoparasites). For big sizes and small sizes (Fingerlings) at three seasons (summer, winter and autumn), specimens were collected from Martyr monument pond, Baghdad Iraq. Results showed the high infection intensity by this copepods and less infection intensity on the fish's tail region for big and small specimens. The study also showed a high infection intensity at summer season and less on autumn season, and very short infection intensity on winter season, this is may be can explain by the different on pond water temperature seasonally, food supplying and the fishes movement activities. Results were showed that the infection intensity was higher at the fingerlings than in big fishes, that was may be due to the ability of small sizes fingerlings to move and touch with the algae (Spirogyra, horse tails) and other aquatic plants living near the edge of the pond comparing with the middle and deep water of the pond.
A Problem for Immanent Universals in States of Affairs
Authors: Raven Michael J.
Published: July 2022

This paper raises a problem for the pair of views that universals are immanent in their instantiations and that these instantiations, or states of affairs, are somehow constructed from the instantiated universals. It is argued that the pair is inconsistent. The first view implies that universals are prior to states of affairs, whereas the second view implies that states of affairs are prior to universals. This paper does not attempt to solve this problem, but rather to formulate it precisely. That promises to illuminate how to solve the problem if it can be solved, or why it cannot be solved if it is unsolvable.
Path and Mechanism Optimization of Integrating Tourism Planning into Territorial Spatial Planning System
Authors: Wang Ting , He Jiawen
Published: July 2022

Tourism planning is a kind of protective development planning for scientific and rational optimization of tourism space and tourism resources. At present, there have been problems in tourism planning, such as unclear role, imperfect content system and immature compilation technology, which have caused difficulties in landing tourism planning and conflicts with other planning. Under the background of territorial spatial planning system reform, tourism planning into the territorial spatial planning system has great theoretical significance and very urgent practical significance.  Based on the analysis of the existing problems and causes of tourism planning, this paper puts forward that ' multi-planning ' should include tourism demand and influence in the process of ' integration ', and the optimization path of tourism planning compilation system oriented by integrating into the territorial spatial planning system.  And from the census of tourism resources, modify the general rules of tourism planning, the introduction of tourism planning preparation methods, the establishment of tourism sector spatial information subsystem, strengthen the typical tourism destinations spatial planning guidance and tourism planning and other ' multi planning ' department discussion and exchange of six aspects put forward tourism planning into the territorial spatial planning system optimization strategy.  The purpose is to standardize the preparation of tourism planning, actively integrate into the territorial spatial planning system, promote the internal cohesion of the ' five levels and three categories ‘territorial spatial planning system, and scientifically guide the planning and construction of tourism destinations.
Preface: 3rd International Symposium on the Frontiers of Biotechnology and Bioengineering (FBB 2022)
Authors: He Wei
Published: July 2022

This proceeding includes original and peer-reviewed research papers from the 3rd International Symposium on the Frontiers of Biotechnology and Bioengineering (FBB 2022: http://www.fbbconf.org/), in Hong Kong, China during May 14-15, 2022.

For thousands of years, humankind has used biotechnology in agriculture, food production, and medicine. Biotechnology is the research and development in the laboratory using bioinformatics for exploration, extraction, exploitation and production from any living organisms and any source of biomass by means of biochemical engineering. Bioengineering is the application of the principles of engineering and natural sciences to tissues, cells and molecules. FBB aims to bring together leading academic scientists, researchers and research scholars to exchange and share their experiences and research results on all aspects of Biotechnology and Bioengineering. It also provides a platform for academic scientists, researchers and research scholars, doctors, doctoral students and related professionals to present and discuss the most recent innovations, trends, and concerns as well as practical challenges encountered and solutions adopted in the fields of Biotechnology and Bioengineering. All authors and participants are kindly encouraged to contribute to and help shape the conference through submissions of their research abstracts, papers and posters.

FBB 2022 received 103 submissions, and more than 30 of them had been accepted by our reviewers in FBB 2022. By submitting a paper to FBB 2022, the authors agreed to the review process and understood that papers undergo a peer-review process. Manuscripts were reviewed by appropriately qualified experts in the field selected by the Conference Committee, who gave detailed comments and-if the submission was accepted the authors would submit a revised version that took into account this feedback. All papers were reviewed using a double-blind review process: authors declared their names and affiliations in the manuscript for the reviewers to see, but reviewers did not know each other’s identities, nor did the authors receive information about who had reviewed their manuscript. The Committees of FBB 2022 invested great efforts in reviewing the papers submitted to the conference and organizing the sessions to enable the participants to gain maximum benefit.

Hopefully, all participants and other interested readers will benefit scientifically from the proceedings and also find it stimulating in the process.

With our warmest regards,

Wei He

Conference Organizing Chair
Association Between Dietary Patterns and the Risk of Hypertension Among General Population in China and America
Authors: Li Siying , Liang Xiaoyan , Yao Tianyu
Published: July 2022

Hypertension is one of the risk factors of many diseases such as cardiovascular disease and stroke, and it has become increasingly prevalent worldwide. Although elevated blood pressure is related to many different factors, some studies have found that people's dietary patterns seem to be closely related to the development of hypertension. This paper aimed to compare the dietary patterns in China and America and to explore how they affect the incidence of hypertension in both countries. Through analysis, high sodium diets, substandard vegetable intake, and high-temperature cooking methods in both countries were found to be hazard factors that might increase the prevalence of hypertension. The difference was that the high sodium intake in America mainly comes from processed food, while the sodium intake in China mainly comes from salt added during cooking. In addition, the relatively high intake of whole-grain diet in China may also be one of the reasons for the relatively low prevalence of hypertension in China. In terms of intervention on hypertension, although America has higher compliance with the DASH diet, it is still important to popularize dietary guidelines and hypertension-related knowledge in order to help the public better improve their health status. However, the current research has no definite evidence to prove the relationship between diet and hypertension, so more research and data still need to be found.
Effect of refloated soil dust on oxidative stress and apoptosis in rat lung
Authors: Guo Qingyun , Liu Yanju , Cheng Zhibin , Li Junfang , Shan Yunfang , Zhong Zhenyu , Liu Qingyang , Zhang Tingting
Published: July 2022

Little study has illustrated the associations between inhalation of refloated soil dust and the morbidity of respiratory disease in animals. In this study, soil dust samples in arid and semiarid areas of China were collected for investigating the underlying biotoxicity and mechanisms of oxidative stress and apoptosis in rat lung induced by inhalation of refloated soil dust. The soil dust samples were collected from the arid and semiarid areas in Zhangjiakou city, located close to Inner Mongolia Plateau, China. After intratracheal instillation of soil dust, superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) activities in rat lung were declined in a dose-dependent relationship, and pathology changes in lung tissue were also enhanced along with increased levels of soil dust. Meanwhile, apoptotic cells were scattered in the pulmonary epithelial and distributed in the mesenchyma, and the apoptotic index was significantly increased in rat lung instilled by soil dust. Besides, soil dust promoted Bax expression and inhibited Bcl2 expression, i.e., increased Bax/Bcl2 ratio in a concentration-dependent manner. In summary, short-term exposure to soil dust caused oxidative damage and induced apoptosis in rat lung through the regulation of Bax and Bcl2 expression.
Effect of Eight Different Methods for Preventing Incontinence-associated Dermatitis: A Network Meta-analysis
Authors: Zhen Haiyan , Zhang Zhigang
Published: July 2022

The objective is to systematically evaluate the effects of different methods in the prevention of incontinence-associated dermatitis. Methods is based on Searched PubMed, the Cochrane Library, Web of Science, EMbase, CNKI, VIP and CBM,and the search time limit was all built until January 2019.Two investigators independently screened the literature, extracted the data and evaluated the risk of bias in the included studies. The R 3.5.2 software gemtc package, JAGS 4.3.0, and Stata 13.0 software were used for analysis. Results: A total of 24 articles were included and 2367 patients were included. Mesh meta-analysis results show that the skin protective agent, ostomy bag combined drainage device, ostomy bag, ostomy bag combined with skin protectant, built-in tampon to prevent the incidence of incontinence-related dermatitis is better than conventional care; The effect of devices and ostomy bags on preventing the incidence of incontinence-associated dermatitis is better than that of drainage devices and built-in tampon; the effect of ostomy pouch combined with skin protectant on preventing the incidence of incontinence-associated dermatitis is better than that of built-in tampon. The ranking probability map shows that the ostomy combined drainage device is a better solution to prevent the incidence of incontinence-associated dermatitis. Conclusion: According to the results of mesh meta-analysis and probabilistic ranking, the effect of the laparoscopic combined drainage device bag on preventing the incidence of incontinence-associated dermatitis is better than other methods. Future research should also be focused on the direct comparison of effects between different methods and the evaluation of cost effectiveness.
Research Progress on Exercise Prescription for Chronic Pain
Authors: Xu Yunting
Published: July 2022

In recent years, exercise prescription has gradually provided a new idea for the treatment of chronic pain, which has been proved to be effective in alleviating pain and preventing recurrence in more and more literatures. This paper attempts to review the mechanism of chronic pain and the application of exercise prescription in patients with chronic pain, with the aim of providing reference for future clinical work.
The importance of cerebral organoid technology in medicine
Authors: Wong HakKei
Published: July 2022

Because of the intricate nature of the nervous systems, neurological diseases have always been one of the least studied areas of pathology and medicine. Currently, there is no cure for these kinds of diseases but only medications or therapies that relieve symptoms and minimise suffering. Thus, cerebral organoids derived from human pluripotent stem cells are produced in order to study the development and pathology of the human brain, especially the embryonic stage, and to model neurological diseases. In this dissertation, I will make a judgement on the appropriate usage of cerebral organoid in investigating neurological disease through exploring and assessing the effectiveness of the cerebral organoids modeling Zika Virus and Alzheimer’s disease and examining the ethical issues arising from this practice.
Research Progress on Chemical Composition and Pharmacological Action of Exocarpium Citri Grandis
Authors: Feng Fang
Published: July 2022

Exocarpium Citri Grandis is a famous genuine regional drug in Guangdong province, which contains flavonoids, volatile oils, polysaccharides, curmarins and other effective components. In vivo and in vitro experiments have proved that it has many pharmacological actions, such as expelling phlegm and relieving cough, anti-inflammation, anti-oxidation, lowering blood glucose and lipids, protecting myocardium and so on. In order to better control the quality of tangerine and explore its potential pharmacological action, this paper reviews the research progress of Exocarpium Citri Grandis from two aspects of chemical composition and pharmacological action at home and abroad in recent years, and its applications in clinic and food industry are prospected.
Pathological Mechanisms Underlying IgE-mediated Food Allergy
Authors: Wei Tianhao
Published: July 2022

Food allergy is an immune disease triggered by abnormal immune responses against harmless antigens that enter through our gut lumen. There are two major pathways that contribute to the food allergic symptoms: IgE-mediated and non IgE-mediated. Among all food allergy cases that have already been discovered, IgE-mediated mechanisms are responsible for over 80-90% of the cases. The IgE-mediated mechanisms include epithelium damage, T helper 2 cell induction, IgE antibody production, and the final symptoms caused by the effector cells. We also discovered that there may exist a potential relationship between B cell metabolism and the IgE production, which ultimately leads to food allergy. At the same time, since more and more people now enjoy more diverse food sources, issues regarding food allergy are outbursting these years as people’s exposure to different food proteins and antigens rapidly increase. It is shown that the United States government is losing billions dollars annually to cover the lost caused by food allergy. Given the worldwide prevalence of the food allergy and the increasingly unhealthy lifestyles of many people, it is highly crucial for us to understand the fundamental mechanisms underlying the IgE-mediated food allergy, which is the most common and influential pathway that risks millions of lives. Therefore, this Review goes over the basic mechanisms underlying the IgE-mediated food allergy, namely how epithelium damage, T helper 2 cell induction, IgE antibody production, effector cell activation, and B cell metabolism lead to the final symptoms of food allergy.
Pioneers of the Carbon Cycle: FUNGI
Authors: Gao Yunpeng
Published: July 2022

The carbon cycle is one of the most important cycles in the Earth's ecosystem. Furthermore, fungi are a key part of the carbon cycle, and their ability to decompose organic matter such as wood and garbage can renew and utilize the carbon in organic matter. This paper combines the logistic model, the first-order kinetic equation, the GLV model and some auxiliary means to analyze the growth and reproduction of fungi. The ability to degrade organic matter is also considered. Also, we obtain the decomposition model of the fungi under the coexistence of many colonies. Firstly, we introduce the logistic model and the first-order kinetic equation (for the first- order reaction) to get the single colony degradation (SCD) model. Then, we get a relatively excellent degradation speed equation. After demonstrating its effectiveness, we extend it into the case of multiple colonies. When it comes to the condition of various colonies, we first classify the colony by Q cluster analysis, then extend the logistic model part in the SCD model to the Gause-Lotka-Volterra (GLV) model. Moreover, we get the rules of colony reproduction under the condition of multi-types fungi. It is found that under other fixed conditions, competitive types will eventually eliminate others. At the same time, we deduce the equation of the descent rate of the multi-types condition on the population quantity, and find that the decomposition ability of the multi-colony can reach the maximum when the competitive ability of each colony is relatively balanced and the degree of competition is appropriate. Then, based on the model, we find many examples of fungi and use their parameters to demonstrate that different climates lead to different species types. At the same time, by treating weather conditions as random quantities, we show that when the weather changes rapidly, there are more competitive colonies in the dry environment while the wet environment may make the low competitive colonies multiply into the largest number of colonies. When modelling, we also give the effect of biodiversity on two aspects of colony degradation, and draw the conclusion that biodiversity is usually helpful for decomposition. Finally, we analyze the sensitivity of the model, explain the influence of parameter changes on the model, and analyze the process of selecting the degradation velocity equation. At the same time, we explain the advantages and disadvantages of the model, and put forward the improvement measures and expansion schemes to make the model more reasonable.
The value of dental implant superior frontal sinus augmentation combined with orthodontic treatment
Authors: Yang Yan , Guo Yang , Luo Guangming
Published: July 2022

To explore the clinical value of dental implant superior frontal sinus elevation combined with orthodontic treatment. From August 2020 to August 2021, 88 patients with maxillary posterior tooth defect were enrolled. There were 44 patients in each group. The experimental group received the combined treatment of upper frontal sinus elevation and orthodontic treatment, while the control group received general prosthodontic treatment. The evaluation indexes included the total treatment time and recovery time of teeth, chewing efficiency, bite force, clinical efficacy and treatment satisfaction data. Data summary showed that the bite force of the experimental group was similar to that of the control group before treatment, and the chewing condition was consistent with the above, P > 0. 05; After different treatment intervention, the bite force of the control group was worse, the chewing condition of the experimental group was better, the effective rate and total satisfaction rate of the control group were less than the experimental group, at the same time, the total repair time of the experimental group was shorter, compared with the control group, there was a significant difference in data, P < 0. 05. The combined treatment of upper frontal sinus augmentation and orthodontics can effectively improve the masticatory efficiency and occlusal ability of patients, improve the clinical treatment effect, and shorten the total treatment and repair time of patients, with higher acceptance of clinical patients, which has an important reference value.
The Progress of Different Pathways for Shank3 to Cause Autism Spectrum Disorder
Authors: Stephanie Lipiäinen , Song Xiaoyu , Lin Zishan
Published: July 2022

Autism spectrum disorder (ASD) is a broad definition of autism based on the core symptoms of typical autism. Statistics show that in every 40 to 59 children, there would be a case of ASD. This severely affects the kid's social acceptability and further development. Although the pathogenesis of ASD is still unclear, it is confirmed that several gene mutations contribute to its symptoms. The Shank3 gene is one of the related genes, and it encodes the multi-domain Shank3 protein, a scaffold protein in the excitatory postsynaptic dense region. The Shank3 gene is widely distributed in the nervous system and plays an important role in maintaining synaptic plasticity. In recent years, researchers have done a large number of experiments as well as investigations about the mechanism of how Shank 3 causes ASD.  This paper reviewed some hypothesis of the Shank3 gene mechanisms which leads to ASD, contributes to further understanding and research on the relationship between Shank3 gene and ASD.
Effect analysis of Shenkang injection on chronic renal insufficiency
Authors: Guan Huai , Xiang Jilian , Yang Jun , Li Hongyu , Li Gaixia , Yang Aiping
Published: July 2022

To investigate the clinical effect of Shenkang injection on chronic renal insufficiency. Methods 88 patients with chronic renal insufficiency were selected as the research object and randomly divided into observation group and control group. The control group was given routine treatment, and the observation group was given Shenkang injection on this basis. The total effective rate, hemoglobin level (Hb), red blood cell count (RBC), urea nitrogen (BUN), serum creatinine (SCr) and endogenous creatinine clearance (Ccr) were compared between the two groups. Results The total effective rate of the observation group (93.18%) was significantly higher than that of the control group (77.27%), and all observation indexes were significantly better than the control group, the difference was statistically significant (P<0.05). Conclusion Shenkang injection has a significant effect on chronic renal insufficiency patients, and can effectively improve the symptoms of weakness, anemia and so on.
Clean synthesis of isoprene with six E. coli engineering strains
Authors: Cui Yixuan , Daroch Maurycy
Published: July 2022

Isoprene is one of the most important platform chemicals containing conjugated double bonds and utilized as the precursor material of varieties of chemical raw materials. Currently, isoprene is mostly produced by petroleum smelting, which produces CO2 and some pollution. In that case, the clean production method of isoprene is still the focus of current research. Isoprene synthase (IspS) catalyzes isoprene formation from a metabolic intermediate DMAPP. The expression level and enzyme activity of IspS from different strains affect the amount of isoprene production. In this study, six IspS protein sequences were obtained by searching literatures and NCBI database based on the phylogenetic analysis. We analysed the conservation of their catalytic structures and constructed pBAD expression frameworks for them. The isoprene synthesis systems in E. coli were built and worked in the best induction condition predicted in our study. We used toluene to collect the isoprene produced in the system detected and compared the productivity of each strain. Our results show that the production in cells were 1.55-5.51 μg/L/h.
Tradizione e peculiarità nelle produzioni ceramiche del Veneto preromano
Authors: Chiaramonte Treré Cristina
Published: July 2022

L’articolo riassume i dati di una ricerca sulla distribuzione e l’utilizzo di un’olla tipica delle botteghe di Padova nell’Età del Ferro. Si tratta di una forma semplice dalle peculiari caratteristiche in parte risalenti all’Età del Bronzo, che con qualche variante si diffonde tra VI e IV secolo a.C., oltre che a Padova, negli abitati e nelle necropoli del Veneto orientale di influenza patavina. La sua presenza traccia le direzioni dei commerci verso nord e nord-est del centro egemone e nel contempo attesta una attitudine alla salvaguardia di tradizioni testimoni di comune identità culturale nel territorio in questione.
Prevalence of Migraine and its Association with Neck Pain Among Students of the University of Lahore
Authors: Fatima Imaan , Mubeen Iqra , Amjad Fareeha , Hashim Adnan , Umer Muhammad , Zahur Mishab
Published: July 2022

Headaches have been associated with a certain collection of mental difficulties, including sadness, anxiety, worries, and frenzied issues. If untreated, cranial discomfort and atypical headache attacks may cause nervousness and sorrow due to the victim's sense of helplessness brought on by the pain's irrationality Objective: To find out the prevalence of migraine attacks and its association with neck pain among students of the University of Lahore Methods: Data was collected from 217 students of The The University of Lahore, having migraine and neck pain by using questionnaire of Neck Disability Index and Numerical Pain rating scale for Migraine. The permission was taken from institute and the questions were asked after obtaining consent of student Results: Age distribution among students was 20.88±1.644 years with minimum age of 19yrs and maximum 25 yrs. Out of 217, males with the percentage 28.6 % and 71.4 % females. Students with no migraine were 17.1%, mild migraine were 36.9%, moderate migraine were 27.6% and severe migraine were 18.4%. Out of 217, 7(3.2%) had no neck pain, 6(2.8%) had mild neck pain, 115(53.0%) had moderate neck pain, 74(34.1%) had severe neck pain and 10(4.6%) had very severe neck pain Conclusion: An association between migraine attacks and neck pain was observed.
Bacteriological Profile and Drug Resistance Pattern of Isolates of ICU Patients In Hospital Of Peshawar
Authors: Nabi Muhammad , Zaman Shah , Umar Amna , Rehman Erum , Subhan Zakia , Aziz Nighat , Naeem Nabiha , Anjum Ambreen , Irfan Ullah Irfan Ullah
Published: July 2022

Multidrug-resistant infectious diseases are one of the top causes of death and morbidity among hospitalized patients worldwide. Objective: This study’s aim was to assess the frequency of common bacterial pathogens, as well as their antibiotic sensitivity & resistance, in various Intensive care unit tertiary care hospitals. Methods: The current investigation was conducted from February to May 2021 in multiple ICU at a primary care hospital in Peshawar. Patients who were admitted to any of the hospital's four intensive care units (ICUs) and patients medically speculated of having an infection within 48 hours of arrival were included. Patients' laboratory samples were selected based on clinical suspicion. Antibiotic sensitivity testing was performed on the samples. Result: E. coli 33(26) was the most commonly isolated bacteria across all samples. “In NICU, CONS 17(67.78), in 7(28.28), in MICU, PICU E. coli, E. coli, Pseudomonas spp and Acinetobacter spp.11(22.39), and in E. coli, SICU 17(46.82) were predominantly isolated” “Amikacin 29(88.6), Cefuroxime 21(65), Klebsiella sp. to Cefoperazone+Salbactum 15(79), Pseudomonas to Tazobactum+Piperacillin 12(66), and Acinetobacter sp. to Sulbactum+Cefoperazone 12(66) are commonly used antibiotics against E. coli 12(56)”. Citrobacter spp. (67.8) was observed more followed by Proteus spp. (34.4) and Enterococcus (34.4). Conclusion: In the ICUs, infectious diseases and antimicrobial resistance are key barriers to patient outcome multidrug-resistant as well as expenditure. All intensive care units throughout the world face the issue of lowering the same.
Modified Composite Thermal Control Coatings Irradiatedwith High−Energy Particles
Authors: Harutyunyan V. V. , Badalyan A. O.
Published: July 2022

The main trends in modern space instrumentation are an increase in the active life of spacecraft, the tightness of their structure, and the widespread use of new polymer composite materials. Composite thermoregulatory coatings are designed to maintain the required thermal regime of objects by establishing a balance between the energy absorbed from the outside and the energy emitted into the environment. The aim of this work is to study the structure of new composite thermoregulatory materials (coatings) irradiated with high−energy particles − an electron with an energy of 3.5 MeV and a proton with an energy of 18 MeV, using X−ray diffraction analysis, optical photoluminescence doped with cerium, as well as other coatings, a new composition of thermoregulatory coatings (TRC) was developed by the method of hydrothermal microwave synthesis. According to the results of studies of modified TRCs, it was found that the samples synthesized by the microwave method have a crystalline structure after heat treatment. It is shown that the mechanisms of the effect of radiation spectra on the material medium are completely different and are determined by the atomic−molecular structure of matter. Irradiation with highly energetic particles gives rise to color defect centers of two types.
Exploring Pre-service Teachers’ Perceptions of Teaching Profession Preferences and Teaching Status
Authors: USLU Emine Merve , ÖZGÜN Tuba
Published: July 2022

The study was conducted with 230 pre-service teachers who study in different departments (Primary Education, Turkish and Social Studies Education, Mathematics and Science Education). This study aims to determine the perceptions of the professional preferences and teaching status of pre-service teachers studying in different departments. The correlational survey model was used as a research design. One-Way Analysis of Variance (ANOVA) and t-Tests were used to analyze the data. The current study discussed the professional preferences of the pre-service teachers in the dimensions of “intrinsic” and “altruistic”, the dimensions of their professional status “teacher and the teaching profession value”, “the importance given to the teaching profession” and “cases affecting the teaching profession”. Pre-service teachers’ teaching profession preferences and perceptions of teaching status were examined according to gender, department, and the place of living for a long time. Findings show that there are high levels of relationship between the reasons for choosing a teaching profession and the perceptions of professional status.
Performance evaluation of Internet financial enterprises based on factor analysis
Authors: Zhang Hongmin , Han Yang
Published: July 2022

Iin recent years, China's Internet enterprises and financial institutions have developed very rapidly. The combination of the two - Internet finance has a great impact on people's life. In the fierce market competition, the evaluation of the operating performance of Internet financial enterprises can not only provide investors with investment reference information, but also help managers find their problems in operation and management. Taking Dongfang wealth Information Co., Ltd. as an example, starting from profitability, solvency, operation ability and growth ability, this paper selects ten indicators: gross profit margin, return on total assets, return on net assets, current ratio, quick ratio, asset-liability ratio, total asset turnover, accounts receivable turnover, net profit growth rate and operating revenue growth rate, Factor analysis is used to evaluate its business performance.
Design of Second-Hand Car SCF Platform Based on Block Chain Technology
Authors: Wang Anyu
Published: July 2022

At present, China's used car consumption market is developing rapidly and has a bright future. Against the background of this era, the bank's used car credit business ushered in a major development opportunity. How to effectively carry out the used car credit business and provide more effective and high-quality services has become an important research topic. Among the related financing issues, there have always been problems such as difficulty in confirming rights, difficulty in transmitting information, and lack of credit enhancement measures. Therefore, we designed a financial product, hoping to give full play to the advantages of core enterprises in the supply chain, collaboratively apply new technologies such as Block chain technology, "Internet Plus", and big data, innovate financial products, and support and serve entity enterprises to revitalize accounts receivable, speed up the capital turnover of enterprises, reduce external liabilities, and reduce financing costs.
An Overview of Platform Economy and Its Algorithms: Strengths, Weaknesses and Regulatory Initiatives
Authors: Zhou Yuqi
Published: July 2022

Algorithm-based Platform Economy is growing rapidly, with digital capitalism as its core. Its advantage of accurately matching supply with demand has attracted an enormous amount of capital. However, the monopolistic nature of platform and the intelligent algorithms are constantly violating the bottom line of consumer privacy, making digital economy a weapon for capital to exploit the laboring people. Therefore, they should be strictly regulated, which is the only way for platform economy to deliver real benefits to working people.
Analysis of cash flow statement with Drägerwerk AG as an example
Authors: Lou Hongqian
Published: July 2022

Usually, the normal development of the enterprise because of the daily business transactions constantly, need to estimate the cash flow of the enterprise, so that the enterprise decision-makers grasp the current development of the enterprise, real-time evaluation of the enterprise, so as to make decisions for the enterprise. According to International Accounting Standard (IAS) 7, the cash flow statement reflects the addition and subtraction of cash flow. The main purpose of cash flow statement is to provide information about the financial situation of an enterprise, including the source and use of funds, for decision makers and investors of an enterprise. Cash flow statement is an important index to measure the sustainable development of enterprises and the main factor to measure the financial strength of enterprises. As an integral part of financial statements, cash flow statement can reflect the net assets of enterprises with fair value, and show the operating results and financial status of enterprises through flow changes. It provides a reference for enterprises to test whether they can fulfill their payment obligations, pay dividends and pay dividends to investors. In this context, cash flow statement plays an increasingly important role in the development of enterprises. In order to make a better economic decision, we must study the cash flow statement in an all-round way. Firstly, it studies what information can be disclosed in the cash flow statement. The second research problem discusses the direct method and indirect method for calculating cash flow. Considering that cash flow statement is an important financial statement of an enterprise, any enterprise needs cash flow statement to help enterprise management and investors make decisions. Therefore, the third problem is the specific calculation of cash flow statement and the matters needing attention in the application process.
Risk and Return: An Empirical Analysis of the Optimal Trading Strategies of Gold and Bitcoin from the Perspective of Market Traders with Three Decision Types
Authors: Liu Bin , Li Huaru
Published: July 2022

This paper uses the daily prices of gold and bitcoin from September 2016 to September 2021 to discuss the optimal decision of market traders. LSTM algorithm is used to predict the future price trend of bitcoin and gold. Then, calculate the risk coefficient of Bitcoin and gold trading. Next, the expected returns of gold and bitcoin are obtained according to the determined price forecast value, and combined with the risk coefficient to construct the transaction function. Finally, because the objective function and constraint conditions are linear functions, the results are calculated by using the idea of linear programming. In the whole paper, considering the attitude of market traders in decision-making, three types of decision makers are discussed. Firstly, the time series model is used to predict the data of the same gold and bitcoin. Then, the data predicted by the LSTM model and the time series model are used to calculate the MAE and MSE. By comparing the numerical values, the LSTM model is significantly superior to the time series model, so that the optimal prediction method is proved. Next, for three different decision types of traders, respectively, using the decision model established in 6.1 to find whether the optimal decision point exists and meaningful. The results show that all three types of decision makers can make optimal decisions under the influence of the risk of the predicted data, that is, the risk of the decision model is controllable. Secondly, to demonstrate the sensitivity of transaction costs. Firstly, the fixed commission ratio in the requirements is adjusted, and the commission ratios of bitcoin and gold are adjusted respectively, floating up and down within 20 %. Then, it is brought into 6.1 to calculate the optimal decision-making profit value of traders of three decision-making types. Finally, it is found that the profit value of the optimal decision-making point is very stable. Compared with the profit value calculated by the given commission ratio, the deviation is less than 0.4 %, and the sensitivity analysis of transaction cost is well completed. Finally, but not the most important, it is hoped that the model studied in this paper can help market traders make optimal strategies when making decisions.
Study of the Impact of Ethical Leadership on Innovation Performance: The Mediating Role of Interaction Equity
Authors: Zhang Yifan
Published: July 2022

Based on equity theory, this study constructs the influence mechanism of ethical leadership on innovation performance. This study uses questionnaire surveys to investigate more than 10 enterprises in Hubei, Henan, Hunan, Shanghai, and Beijing, and finally collected 235 valid samples. Using SPSS26.0 and Mplus7.4, hierarchical regression analysis is used to verify the hypotheses put forward in this study. Finally, a total of four conclusions are obtained. First, ethical leadership has a positive effect on employees' innovation performance. Second, interaction equity mediates the relationship between ethical leadership and employees' innovation performance. Third, leader-member exchange(LMX) positively moderates the relationship between ethical leadership and interaction equity. That is, the higher the degree of LMX, the stronger the positive influence of ethical leadership on interaction equity is. Fourth, LMX moderates the mediating role of interaction equity between ethical leadership and innovation performance. That is, the higher the degree of LMX, the stronger this mediating role is. This study not only expands the research on ethical leadership, but also provides management enlightenment for enterprises to implement appropriate management methods and improve innovation performance.
The Regulation Anti-Unfair Competition Law on Either-or Choice Behavior of Online Platforms in E-Commerce
Authors: Xu Ziyan
Published: July 2022

With the prosperous development of the digital economy, major e-commerce platforms have increased their competitive advantage by implementing either-or choice behavior on operators within their platforms. Compared to the anti-monopoly law, which has strict application standards, the Anti-Unfair Competition Law covers a wider range of either-or choice behavior. However, the concept of neutrality of the article exclusive of Internet (the Article 12) neglects the infringement properties of unfair competition, and the enumeration of behaviors lacks typology. If the general articles are too flexible, it will lead to the offsite of application, and the main elements of judgment rely excessively on subjective measurement. In this regard, based on accurately grasping the infringement attributes of the conduct, the abstract features of the Internet article are clarified and supplemented, and the types are classified according to the standard of “directly affecting the free decision of consumers”. At the same time, the principle of “more or less” can be used to dynamically understand the application of Internet articles and traditional regulatory provisions in the regulation of unfair competition in the network environment. In addition, the principle helps to rationalize the relationship between the Internet underwriting articles and the general article, more objectively qualify the subjective discretionary scope of the general articles by whether the behavior has a legitimate interest and positive impact, and reduce the escape of the Internet article.
The Path and Value of User Participation Construction in Brand New Media Marketing
Authors: Liu Ziqing
Published: July 2022

Under the Internet communication ecology, the number of China’s self-media has exploded, and enterprises have built their social accounts to form brand marketing, which has become a communication force that cannot be ignored. Nowadays, under the leadership of the chairman Dong Mingzhu, the national home appliance manufacturing brand "Gree Electric" has firmly grasped the new media operation, and successfully created online marketing with both sales and word-of-mouth. This paper takes the operation strategy of the Weibo account "Dong Mingzhu's Self-Media" as an example, analyzes the content, data and cases to conclude the reasons for its success, and tries to explore the build path and value of the sense of user participation, to provide a certain reference for the new media operation of China’s enterprises.
Progress, Prospect and Challenge of VR Technology Application in the Field of Business Management
Authors: Lin Yufan
Published: July 2022

Business management is facing a new digital revolution. In recent years, the Internet-led information technology revolution has greatly improved management efficiency, while the Internet has also degraded the reality experience. Since late 2010, mixed reality technology has brought a new round of information technology revolution to business management by virtue of its double potential of immersion and experience. In order to deeply investigate the VR technology application in the field of business management, existing relevant researches were systematically integrated in this paper, the development and commercial application of virtual reality were summarized, and the specific application of virtual reality in the field of business management was combined.Business management;
Research on the evaluation system of international non-governmental organizations participated by enterprises
Authors: Feng Xinxin , Ruan Wenjing , Xu Yang
Published: July 2022

This paper constructs a set of evaluation indicator system for international non-governmental organizations participated by enterprises. The evaluation indicator system includes two aspects (objective situation and value contribution of INGOs) as well as four dimensions (activeness, influence, output and other effects). We also designed the evaluation process for a group company.
The impact of COVID-19 on supply chain of cross-border logistics: review and suggestions
Authors: Ge Wenxi , Zhang Yi
Published: July 2022

In the end of 2019, an unprecedented outbreak which commonly called COVID-19 occurred in Wuhan, Hubei Province, China, and soon extended nationwide. In order to control the spread to inhibit further deterioration, the central government announces total China lockdown to tackle corona virus, which poses a dilemma to the logistics of China both inland and cross-border trade. In response to the call of country to stay home, most companies have started to limit the working hours of workers, these largely reduced the efficiency of enterprises. Beside that government have established the policy that cargoes and the person who in charge of transport needed be exam for whether they have carry the virus during the transportation, which would exert some effect on not only the inland logistics but also that of multinational logistic such as lengthen the delivery time. This essay aim to dig out the main issues existing in supply chain during the pandemic and give proper solutions to ease the troubles.
Influencing factors for green supply chain management:a qualitative paper based on ESG concept
Authors: Li Qiuhuizi
Published: July 2022

At present, green supply chain management is one of the hot spots in supply chain management. For the long-term future world of enterprises and the harmony between human beings and nature, the implementation of green supply chain management should be vigorously promoted. The article outlines the five most researched areas of green supply chain management through a keyword classification, clearly explaining the potential for green supply chain development in both theoretical and practical terms. On this basis, the article analyzes the influences on the green supply chain management from three perspectives: environmental, social and governance. In conclusion, environmental, social, governance philosophy will strengthen overall green supply chain management capabilities.