bluuebunny/crossref_metadata_2025 huggingface dataset:
Generalized Morphea-Like Scleroderma Occurring in People Exposed to Organic Solvents
Authors: Yamakage Akio , Ishikawa Hidekazu
Published: October 2009

Adult patients having systemic scleroderma with generalized morphea-like skin lesions, whom we had examined during the past 7 years, were reexamined because their clinical features were somewhat similar to those of occupational scleroderma described hitherto. Out of 9 patients, 7 patients had been engaged in occupations exposing them to organic solvents for a long time before or after Raynaud’s phenomenon appeared. A skin sclerosis was also induced experimentally with some aliphatic hydrocarbons of organic solvents.
Unilateral Skin Lesions, Cataracts, Optic Glioma and Retardation – a Variant of the Epidermal Nevus Syndrome?
Authors: Burck Uta , Held Karsten R.
Published: October 2009

A girl with unilateral partly depigmented partly hyperpigmented atrophic skin lesions, cataracts, optic glioma, and mental retardation is presented. Differential-diagnostic aspects are discussed. It remains to be seen whether this case represents a variant of the epidermal nevus syndrome, an unusual type of X-linked dominant chondrodysplasia punctata or a separate nosological entity.
Neurosyphilis heute
Authors: Stöckli Hans Rudolf
Published: October 2009

Since there has been an increase in the number of patients suffering from syphilis during the last 2 decades, neurosyphilis has to be seriously considered in many unclear neurological cases. Atypical, often monosymptomatic clinical pictures make the diagnosis difficult. The exact analysis of the spinal fluid including antibodies against Treponema pallidum is necessary for the diagnosis. In contrast to former treatment schedules, now ultra high doses of penicillin are recommended and seem to be absolutely necessary.
Wie lange überleben Dermatophyten im Wasser von Hallenbädern
Authors: Fischer Emil
Published: October 2009

Trichophyton rubrum, Trichophyton mentagrophytes and Candida albicans were shown to survive at least 123 days in chlorinated swimming-pool water of 28–30 degrees, at least 18 days in ozonized water at 34–35 degrees, and at least 25 days in pipe water at room temperature of 23–25 degrees. Concentrations of chlorine and ozone normally used to inhibit bacterial contamination did not devitalize the fungi used in the experiment.
On the Stability of Some Antipsoriatic Active Anthralin (Dithranol) Derivatives
Authors: Schaltegger Alexander , Bloch Ursus , Krebs Alfred
Published: October 2009

The in vitro and in vivo stability of the recently presented antipsoriatic active 10-acylanthralin derivatives is investigated. These compounds are in all probability not independent drugs, but are hydrolytically cleaved in the skin to their parent compound anthralin. The reaction products are detected by high performance liquid chromatography.
Cyclic AMP and Cyclic GMP Production in Normal and Psoriatic Epidermis
Authors: Royer E. , Chaintreul J. , Meynadier J. , Michel B. , Guilhou J.J. , de Paulet Crastes
Published: October 2009

cAMP and cGMP production was determined in normal and psoriatic (involved or uninvolved) epidermis. After homogenization, epidermal strips were incubated with saturating concentrations of ATP or GTP, respectively, for cAMP and cGMP production. Cyclic nucleotides were measured by radioimmunoassay before and after 5, 10,20 min of incubation. The kinetics of cAMP and cGMP production were linear during the 20 min of incubation. Comparison of normal skin, uninvolved and involved psoriatic skin, prior to and after 20 min of incubation showed the following results: cAMP levels were significantly higher in normal skin than in psoriatic skin at zero time (p < 0.01) and after incubation (p < 0.05). cGMP levels were not significantly different in the three tissues at zero time. After incubation, psoriatic involved epidermis exhibited a higher production of cGMP than normal skin (p < 0.05). Thus, the ratio cAMP/cGMP was higher in normal skin than in psoriatic skin at the basic level (p < 0.05) and after incubation (p < 0.01). These results indicate an imbalance in cyclic nucleotides metabolism in psoriatic skin without a significant difference between uninvolved and involved epidermis.
Polyvinylpyrrolidone (Povidone) Storage in RX-Damaged Skin following Procaine-Povidone Intramuscular Injections
Authors: Lachapelle J.M. , Tennstedt D.
Published: October 2009

A man, aged 67, has been treated in 1968 by X-rays for a basal-cell carcinoma of the back. The treatment was followed by an ulcerative radiodermatitis. 3 years later, the patient was treated by ten intramuscular injections of procaine-polyvinylpyrrolidone (or procaine-povidone) for sciatic neuralgia. An orange infiltration appeared progressively around the radiodermatitis. The area was excised in 1979 and polyvinylpyrrolidone (povidone) storage, responsible for the ring-shaped orange hue, could be demonstrated in the dermis and subcutaneous fat. Special stainings confirmed the presumed chemical nature of the deposits. 3 cases of povidone pseudotumours following procaine-povidone injections had been described previously. The preferential deposit of povidone in RX-damaged skin is discussed.
Erythrokeratodermia progressiva symmetrica
Authors: Ruiz-Maldonado Ramón , Tamayo Lourdes , del Castillo Victoria , Lozoya Irma
Published: October 2009

10 cases of erythrokeratodermia progressiva symmetrica are described; 6 were familial, with autosomal-dominant inheritance. The disease started in early childhood, progressed during 1 or 2 years and then remained stationary with sharply marginated plaques remarkably symmetrical, usually sparing the thorax and abdomen. Histologically the picture was psoriasiform. The best therapeutic control was obtained with oral aromatic retinoids. The differential diagnosis is discussed.
On the Resident Aerobic Bacterial Skin Flora in Unaffected Skin of Patients with Atopic Dermatitis and in Healthy Controls
Authors: Gloor M. , Peters G. , Stoika D.
Published: October 2009

In 14 patients with atopic dermatitis the superficial bacteria from unaffected skin were extracted with the scrub method, aerobically cultured, and analyzed qualitatively and quantitatively. For comparison, 12 healthy subjects served as control group. Staphylococcus aureus, as well as coagulase-negative staphylococci were significantly increased in patients with atopic dermatitis. It is assumed that special characteristics of the horny layer in atopic dermatitis favor the growth of aerobic bacteria. The qualitative biotyping and phage typing gave no support to the claim that special bacteria dominate the microbial flora of the skin of patients with atopic dermatitis.
Klippel-Trenaunay-Weber Syndrome
Authors: Parameswara Y.R. , Naik R.P.C.
Published: October 2009

A case of Klippel-Trenaunay-Weber syndrome with spina bifida occulta and enlarged peripheral nerves in the affected hypertrophic limb is reported.
Mucinous (Adenocystic) Carcinoma of the Skin
Authors: Baandrup U. , Søgaard H.
Published: October 2009

A case of mucinous (adenocystic) carcinoma of the skin (MC) is presented. The differential diagnosis against metastasis from mucinous adenocarcinoma (mammary gland, gastrointestinal tract, ordinary sweat gland carcinoma) is emphasized. MC is characterised by its abundant content of non-sulphated mucopolysaccarides. MC is low-malignant with a tendency of local recurrence. Excision and subsequent yearly control is the treatment of choice.
Therapeutische Versuche am Hamstermelanom
Authors: Schuppli R.
Published: October 2009

On the model of the transplantable hamster melanoma Mel 1, the effect of various therapeutic measures on survival time were studied. The following substances or methods were tested: depigmenting agents (pyrocatechol and derivatives), immunotropic procedures (cytostatics, cortisone, BCG, smallpox vaccine, levamisole) and the inoculation of irradiated melanoma cell suspensions prior to tumour implantation. Only suspensions treated with 7,200 R had a prolonging effect on survival time.
A propos d’un cas de pseudo-granulome pyogénique de l’oreille
Authors: Colomb D. , Weltert Y.-A. , Brechard J.L. , de Rivoyre V.
Published: October 2009

The authors have recently come across a female patient with pseudopyogenic granuloma and have taken this opportunity to recall the clinical and histological features of this disease which was described in 1969 by Wilson Jones and Bleehein. In this connection, they have studied the relationship of this disease with similar entities, i.e. subcutaneous angiolymphoid hyperplasia with eosinophilia (described by Wells and Whinster in 1969) on the one hand and Kimura’s disease (described by Kimura in 1948) on the other hand. Whereas subcutaneous angiolymphoid hyperplasia with eosinophilia seems to be an evolutive form developing from pseudopyogenic granuloma, Kimura’s disease differs from it clinically and histologically and is considered as a borderline form.
Iron Content of Skin before and after Thalidomide Treatment of Lepra Reaction
Authors: Sheskin Jacob , Gorodetsky Raphael , Weinreb Arye , Loewinger Ezra
Published: October 2009

The concentration of copper, zinc and iron in the skin of patients suffering from lepra reaction was measured by diagnostic X-ray spectrometry (DXS) at the sites of the lesions before and after treatment with thalidomide. The results were compared with the levels of these elements in the skin of healthy individuals. No significant changes in the copper level of leprous skin were found. The zinc levels showed significant elevations in some lesions with no apparent trend. The iron level in the affected areas had highly elevated values in all cases of lepra reaction. However, in contrast to the fast clinical improvement which followed the treatment with thalidomide, the iron levels did not decrease for prolonged periods.
Evaluation of Clofazimine in Vitiligo
Authors: Shukla S.R.
Published: October 2009

20 patients with vitiligo were treated with 100 mg of clofazimine daily. Half of these cases were exposed to sunlight and the remaining cases were given no sun exposure. After 3 months of therapy, repigmentation of lesions was seen in 2 cases only, 1 in each group. Sun exposure had no beneficial effect.
Transfer Factor in the Treatment of Herpes Simplex Types 1 and 2
Authors: Khan Amanullah , Hansen Beth , Hill N.O. , Loeb E. , Pardue A.S. , Hill J.M.
Published: October 2009

Transfer factor potentiates cellular immunity and induces interferon. It was because of these properties that transfer factor was tried in 17 patients with recurrent herpes simplex types 1 and 2. Transfer factor was administered in doses ranging from 5 to 10 U/m2 i.m. The interval between injections varied from 1 week to 3 months. 16 patients could be evaluated clinically in whom the recurrence rate decreased from 10.7 ± 6.1 to 2.1 ± 2.5 (mean SD). The reduction was statistically significant. 8 patients were completely free of disease while the other 8 had a reduced number of episodes during the period of observation. 7 patients had abnormal T cell function as reflected by the low number of T cells or low lymphocyte transformation. Statistically significant improvement in the T cell function was observed. Delayed hypersensitivity skin test reactions also improved significantly.
Atypical Kaposi’s Sarcoma in a Patient with Vitiligo and Pernicious Anemia
Authors: Ruzicka Thomas
Published: October 2009

A single nodular tumor localized on eczematous lesions present for 17 years developed in a patient with vitiligo and pernicious anemia. Histological examination revealed an atypical Kaposi’s sarcoma. Lymph node metastases showed an impressive response to vinblastine.
Long-Term Local Trioxsalen Photochemotherapy in Psoriasis
Authors: Väätäinen Niilo , Hannuksela Matti , Karvonen Jaakko
Published: October 2009

Good results were achieved in psoriasis with trioxsalen baths and UVA in 92% of 158 patients during initial treatment and in 83% of 139 patients during long-term treatment. Grade I-II local burns were encountered in about 7% of the patients. In addition, itchy skin pain was experienced by 2 patients, and in both of these the therapy was discontinued. Neither skin malignomas nor other serious side effects were seen.
Erythropoietic Protoporphyria in Slovenia
Authors: Kansky Aleksej , Berčič Marija
Published: October 2009

32 patients with EPP were detected in Slovenia, which gives an incidence of 1.71 cases/100,000 inhabitants. 20 patients had typical clinical symptoms and increased values of laboratory assays, 12 patients had either slightly expressed clinical symptoms or increased values of laboratory tests; these patients were diagnosed as latent cases. The patients belong to 12 families, no blood relationship between these families could be established. In 7 families the latent carriers of this inborn error of the porphyrin metabolism were detected. Almost all patients live in two distinct, rather small geographical areas, one in north-eastern Slovenia and the other near Ljubljana.
Problems with Commercial Formulations of 8-Methoxypsoralen
Authors: Monbaliu J.G. , Bogaert M.G. , De Bersaques J. , Hindryckx Ph.
Published: October 2009

Plasma concentrations of 8-methoxypsoralen were measured in 8 psoriatic patients after administration of two commercial solid formulations and of an 8-methoxypsoralen solution. Systemic availability as measured by the area under the concentration versus time curve was much higher for the solution than for the two commercial formulations. For the solid formulations, a large inter- and intraindividual variation in plasma concentrations was found and in many cases no plasma levels could be measured. Administration of the solution gave always more reproducible plasma concentrations in function of time.
IgE Serum Levels in Psoriasis
Authors: Negosanti M. , Fanti P.A. , Gasponi A. , Orlandi G. , Liverani L. , Tosti A.
Published: October 2009

Examination of IgE serum levels in 37 patients with psoriasis showed statistically significant values higher than normal when the extent of skin involved was more than 50%.
Occupational Scleroderma-Like Disorder Occurring in Men Engaged in the Polymerization of Epoxy Resins
Authors: Yamakage Akio , Ishikawa Hidekazu , Saito Yoshio , Hattori Akira
Published: October 2009

A new occupational disorder characterized by skin sclerosis is described. This disease developed acutely in workmen exposed to the vapor of epoxy resins. Based on animal experiments, an amine [bis(4-amino-3-methyl-cyclohexyl) methane] is suspected of being the causative agent of the skin sclerosis.
Treatment with an Oral Aromatic Retinoid in Linear Porokeratosis
Authors: Pehamberger H. , Konrad K.
Published: October 2009

Linear porokeratosis is a rare variant of porokeratosis of Mibelli and usually occurs in childhood. A 15-year-old boy is presented with typical clinical lesions of linear porokeratosis on the extensor surface of the right arm exhibiting the classical histopathologic criteria of the disease. Treatment with an oral aromatic retinoid resulted in a remission of the lesion.
A Retrospective Study of Patch Test Results from 163 Patients with Stasis Dermatitis or Leg Ulcers
Authors: Dooms-Goossens A. , Degreef H. , Parijs M. , Kerkhofs L.
Published: October 2009

Patch test results from 163 patients with leg ulcers and/or chronic venous insufficiency, tested with a modified ICDRG standard test battery and a pharmaceutical test series, are analyzed and compared with the results obtained from a randomly selected control group of patients with eczematous conditions. A sensitization index for the most common contact allergens present in this test series is calculated, and the relevancy of hypersensitivity to specific topical agents is determined.
Über neurogene granuläre Zellen und ihre Beziehungen zum sogenannten Myoblastenmyom
Authors: Altmeyer P.
Published: October 2009

A report on granular cells found in biopsy material is presented. Morphologically identical patterns were seen in a pigmentated granular ‘rankenneuroma’ and in a patient with a morphea of the tongue. The independent development of granular cells in tumorous and nontumorous tissue supports the idea that the so-called granular cell myoblastoma originates from degenerative alterations of Schwann cells.
Le sol, réservoir des agents de mycoses opportunistes
Authors: Pereiro-Miguens M.
Published: October 2009

We studied the soil as a reservoir of vegetable detritus, keratinous materials of birds, terrestrial animals and micro-organisms. In the last group we can mention the bacteria and fungi. We classified the opportunistic fungi in three groups: (1) parasites of plants or growing on the vegetable detritus; (2) geophylic dermatophytes; (3) pathogenic fungi that in some cases behave like opportunistic ones. In each group we studied the opportunistic fungi of the soil, their relations with its chemical and physical composition, the mycoflora and the role of animal habitats.
Treatment of Mycosis fungoides with Heat-Killed BCG and Cord Factor
Authors: Cohen Haim A. , Bekierkunst Adam
Published: October 2009

6 patients with mycosis fungoides in different stages of the disease were successfully treated with intralesional injections of 1 % mineral oil emulsions of killed BCG and cord factor, and/or topical application of an ointment containing killed BCG and cord factor.
Hidrotic Ectodermal Dysplasia
Authors: Pierard G.E. , van Neste D. , Letot B.
Published: October 2009

Description of a patient presenting an hidrotic ectodermal dysplasia. Clinical signs were hypotrichosis, dystrophic nails, palmoplantar keratoderma, absence of teeth and hyperhidrosis.
Follicular Contact Dermatitis Due to Formaldehyde
Authors: Uehara Masami
Published: October 2009

2 patients with textile contact dermatitis due to formaldehyde developed follicular, papular lesions. Histologically these papules showed eczematous changes in the follicular epidermis and mononuclear cell infiltrates in the dermis around the involved follicle. The skin between the papules was intact. It is suggested that the concept of ‘dermal’ contact sensitivity does not fit for the explanation of papular dermatitis due to formaldehyde.
Association d’acrokératose verruciforme à la poïkilodermie congénitale en tant qu’entité dermatologique
Authors: Marill F.-G. , Vodov I.
Published: October 2009

An 18-year-old young man, presents multiple areas of poikilodermia since 1 year of age, and papules like flat warts, essentially on the back of his hands and feet, since 10 years of age. The examination of 16 of his closest relatives led us to discover 1 case of poikilodermia and acrokeratosis verruciformis, 1 case of poikilodermia and 3 cases of acrokeratosis verruciformis. Observations on the association of poikilodermia and acrokeratosis verruciformis have already been reported in the literature as well as comparable morphological facts, but without family lesions and without histological examinations. Thus, rare patients are presenting both congenital poikilodermia and acrokeratosis verruciformis. In the families of 3 of these patients, some members are similarly afflicted, whereas others present independently either poikilodermia or acrokeratosis. In several reports in the literature and in our cases, the histological picture of verruciform papules was the same as Hopf’s acrokeratosis verruciformis. These particularities led us to consider the association of Hopf’s and Thomson’s diseases as an entity.
Immunological Studies in Psoriasis
Authors: Obałek Sławomir , Haftek Marek , Gliński Wiesław
Published: October 2009

Quantitative techniques of sensitization to 2,4-dinitrochlorobenzene (DNCB) was used to determine in psoriasis the intensity and frequency of allergic reactions to DNCB following primary challenge with 2,000 μg allergen and secondary challenge with decreasing doses of DNCB. 56 patients with psoriasis and 23 healthy volunteers were examined. Frequency of positive reactions to DNCB was similar in both groups, since all normal controls were sensitized, whereas only 8 of 56 psoriasis cases failed to develop delayed hypersensitivity to DNCB. However, the intensity of acquired contact allergy was significantly diminished in psoriasis in comparison with controls. The patients with stationary skin lesions resembled the normal population in the intensity of reaction to DNCB. Decreased intensity of DNCB sensitization seemed to be related to the activity of the disease, but not correlated with the extent of the lesions. A relationship was found between reduced reactivity to DNCB and decrease in E rosette-forming lymphocytes. The data suggest that the impaired function of T lymphocytes in active psoriasis could be responsible for both, defective recognition of contact antigens, such as DNCB, and the alteration of secondary response to DNCB.
REM Sleep Determined Using in utero Penile Tumescence in the Human Fetus at Term
Authors: Koyanagi Takashi , Horimoto Naoki , Nakano Hitoo
Published: October 2009

To assess how REM/NREM periods can be linked to the determination of the REM/NREM sleep and/or awake state, we have investigated the relationship between the REM/NREM periods and penile tumescence in the human fetus. This study was made on 11 male fetuses from 36 to 41 weeks of gestation. Eye movement and penile tumescence were simultaneously examined with an observation window of 60 min, using two separate real-time ultrasound systems. The mean percentage of the total duration of penile tumescence during the REM period and that during the NREM period was 77.7 and 15.8%, respectively. In all cases, the total duration of penile tumescence during the REM period against REM duration was greater than the duration of tumescence during the NREM period against NREM duration with statistical significance. This indicates that the fetal penile tumescence is strongly associated with REM period and the REM period containing penile tumescence in the human fetus can be considered equivalent to REM sleep in utero. In addition, the finding that there exists a part of the REM period lacking penile tumescence suggests the possible origin of the awake state, brought about by advances in fetal development at this stage of gestation.
Keratosis lichenoides chronica
Authors: Kint A. , Coucke C. , de Weert J.
Published: October 2009

Description of a case of keratosis lichenoides chronica with presence of blisters. Histologically, the initial lesion seems to be localized at the dermo-epidermal junction. The vessels of the upper dermis are altered.
Axillare Granulome (Zirkonium?)
Authors: Kleinhans D. , Knoth W.
Published: October 2009

Deodorant preparations containing Zirconium may induce axillary granulomas of allergic origin. The case of a 49 years old female patient is presented, who developed axillary granulomas after having used a deodorant preparation containing Zirconium.
Psoriasis: A Review
Authors: Baker Harvey
Published: October 2009

The recent literature relating to pathogenesis, clinical features and management of psoriasis has been reviewed. The features of the accelerated epidermopoiesis are described and its relationship to a possible primary fault in keratinisation or dermal influences discussed. The present position on the genetics and epidemiology of psoriasis is summarised. Recent observations on the relationship of histocompatibility system antigens to ordinary and pustular psoriasis could lead to important advances. Clinical discussion is confined to psoriasis in childhood, the hair, nails and mucosal psoriasis; pustular psoriasis and psoriasis arthropathica.
Unilateral Facial Hyperhidrosis
Authors: Bedi T.R. , Bhutani L.K.
Published: October 2009

Two patients with unilateral facial hyperhidrosis, a rare disorder of the sweat glands, are described. Employing thermal and carbachol stimulation tests, the functional status of sweat glands on the affected sites were studied. A marked increase in sweat gland activity was noted on the affected areas as compared to the contralateral normal sites. The histological examination of the affected skin revealed considerable enlargement of the sweat glands with dilatation of the sweat ducts and an intense mononuclear infiltrate in the periductal area. The epidermis, at places, showed spongiform vesiculation invaded by an identical inflammatory infiltrate. The striking histological resemblance of this condition to the dyshidrotic eruption commonly encountered on the hands and the feet is stressed.
Fox-Fordyce Disease in the Post-Menopausal Period Treated Successfully with Electrocoagulation
Authors: Pasricha J.S. , Nayyar K.C.
Published: October 2009

Fox-Fordyce disease is a relatively uncommon dermatosis classically occurring in females at the time of puberty and very resistant to treatment. We are reporting the cases of two women who developed this disease in the post-menopausal period and were treated with electrocoagulation of the lesions. Both these patients have been symptom-free for the last year. This method is simple and is therefore recommended for further trial.
Skin Colour Changes in Psoriasis. Effect of UV Light Irradiation
Authors: Tring F.C.
Published: October 2009

The change in colour of clinically unaffected psoriatic skin resolving concomitantly with distant sites of UV-irradiated psoriatic lesions was measured by a spectrophotometer. Skin colour was compared between psoriasis and an area of unaffected skin on a limb protected from UV light while the rest of the body received conventional treatment with UV light. Initially, there was a rapid loss of hue (represented by a flattening of the spectrophotometric curve) while unaffected skin showed elevated measurements which persisted during the course of treatment and subsided slowly for up to 2 weeks after cessation of UV light treatment. Clinically undetectable psoriatic lesions showed persistently raised spectrophotometric measurements for up to 10 weeks after cessation of treatment. This report suggests that a systemic factor stimulated or released by whole body UV light irradiation concomitantly influences the resolution of psoriatic lesions protected from the local effects of UV light.
A Case of Bullous Reticulosis
Authors: van Velde J.L.
Published: October 2009

Three months before his death, a man with a chronic respiratory disease developed a skin condition characterized by bullae on infiltrated lesions. Histologically, there were signs of mycosis fungoides. The fever responded to cytostatic drugs but not to antibiotic drugs. During antibiotic and cytostatic therapy, the patient died of sepsis. At autopsy, no signs of reticulosis were found in the internal organs or lymph glands.
Isolation of Melanosomes from Keratinous Material – A New Method
Authors: Borovanský J. , Hach P.
Published: October 2009

A new, simple and quick method for the isolation of melanosomes from hair has been developed. The hairs were disintegrated by treatment with 1 n NaOH and the melanosomes separated by differential centrifugation. Electron microscopy examination confirmed that the results of this procedure are better than those obtained by any previously described method, both with regard to the purity and the intactness of the separated melanosomes. The methods of Gjesdal and of Bolt have been critically evaluated.
Role of Keratinases in Dermatophytosis
Authors: Grappel Sarah F. , Blank F.
Published: October 2009

Hartley strain, male guinea pigs were cutaneously infected at the nape of the neck with T. mentagrophytes var. granulosum. Guinea pigs were also immunized with keratinases (I and II) in Freund’s complete adjuvant. Guinea pigs sensitized by cutaneous infection developed dermal reactivities of the delayed type, the most intense reaction being to the heat-inactivated keratinase II. The cutaneous reactions to both keratinases were greater than the reactions to commercial trichophytin. No circulating antibodies to the enzymes or commercial trichophytin were detected by immunodiffusion or complement fixation analyses. Guinea pigs immunized with active keratinases had both dermal reactivities and circulating antibodies to the keratinases. Dermal reactivities were detectable seven days after immunization. Circulating antibodies were later detectable by immunodiffusion and complement fixation. Serum γ-globulins from immunized guinea pigs also inhibited the proteolytic activities of the keratinases. Neither delayed cutaneous reactivities nor circulating antibodies to the keratinases were detected in control guinea pigs.
Elektronenmikroskopische Untersuchungen über die Epidermis-Korium-Grenze bei Lupus erythematodes
Authors: Haustein U.-F.
Published: October 2009

In 30 patients suffering from different clinical forms of lupus erythematosus (LE), previously chronic discoid lesions of different activity were investigated by electron microscopy. In early stages we found increased infoldings and reduplications of the basement membrane (BM) along the distinctly elongated basal cell projections and reticulated deposits of BM-like granular to fibrillar material corresponding to immune complexes. In necrobiotic stages these alterations are more distinct and accompanied by necrobiosis and inflammation leading over into the atrophic stage. Between chronic and systemic forms there are transitions and quantitative differences dependent on the duration and activity of the disease. Because of the temporal preference of the subepidermal region in early stages we consider the corium as the site of primary alteration in the LE.
Adenoacanthoma: A Review of 20 Cases, Compared with the Literature
Authors: Carapeto F.J. , Garcia-Perez A.G.
Published: October 2009

20 cases of adenoacanthoma, diagnosed out of a total of 1,100 cutaneous epitheliomas were studied. All cases were facial, with actinic elastose. In 11 of the 20 cases, the appearance was that of a tumor with a central crater. Histopathologically, the characteristic appearance of adenoacanthoma (tubular and alveolar formations with acantholytic and dyskeratotic cells) was associated with structures of squamous cell epithelioma. In 4 of the 20 cases, there were glandular tumoral manifestations derived from the sweat glands. Clinically, they have a local malignancy, and a relative radioresistance. In no case was there gangliar metastasis; but in 2 cases, there was extension along the perineural lymphatics. In 4 cases of acantholytic keratosis, an indication of transition toward adenoacanthoma was seen. This supports the hypothesis that this form of keratosis is the departure-point for adenoacanthoma.
Zur Klinik der Acrodermatitis chronica atrophicans Pick-Herxheimer unter besonderer Berücksichtigung der Immunelektrophorese
Authors: Goor W. , Schwarz-Speck M.
Published: October 2009

Acrodermatitis chronica atrophicans gives a typical change in the composition of the serumproteins. This could be verified in 54 cases during the years 1960–1970 at the Dermatological University Clinic Zurich. Comparative investigations of immunoelectrophoresis in 11 patients before and after treatment in the course of 1 to 4 years partially confirmed these findings, they however showed other typical changes which remained for a long time after successful clinical treatment.
Susceptibility to Infections during Long-Term Treatment with Tetracyclines in Acne vulgaris
Authors: Björnberg A. , Roupe G.
Published: October 2009

51 acne patients on low dosage of tetracyclines for more than 6 months (mean, 16 months) were compared (by means of a questionnaire) with 51 matched healthy controls as to their opinion of the occurrence of symptoms of some types of infection. There was no indication of an increased susceptibility to develop infections. In another series of 44 women, 6 had symptoms of monilial infection of the genitals.
Eine einfache dünnschichtchromatographische Untersuchung des Triglyzerid/Cholesterin-Verhältnisses bei Hauttumoren
Authors: Becker H. , Driban N.
Published: October 2009

Different skin tumors were analyzed for their triglycerid/cholesterol content. A simple thin-layer chromatography technique was chosen for these investigations. The cholesterol content of the mentioned skin tumors was much higher than in normal skin. There was, however, no correlation between the cholesterol content and the malignancy of the tumors.
A Rapid Diagnostic Aid for Herpesvirus hominis Infections in Dermatology
Authors: Black M.M. , McQuillin Joyce , Gardner P.S.
Published: October 2009

An indirect immunofluorescent antibody technique is described which can be used to identify rapidly, specifically and accurately herpesvirus hominis infections affecting the skin. The possible applications of this technique as a diagnostic aid of suspected herpetic infections in dermatology are illustrated and discussed. It is suggested that the method should prove useful in the investigation of all vesicular skin lesions in which infection with herpesvirus hominis is suspected. With the advent of anti-viral agents these techniques are likely to become increasingly important.
The Interaction of Anthralin, Salicylic Acid and Zinc Oxide in Pastes
Authors: Hulsebosch H.J. , Ponec-Waelsch M.P.
Published: October 2009

When anthralin is applied with a zinc oxide paste as vehicle its antipsoriatic activity decreases in less than 3 weeks. Laboratory experiments make it probable that this deterioration is due to an interaction between anthralin and hydrolyzed zinc oxide molecules and simultaneous oxidation of anthralin into inactive 1,8-dihydroxyanthraquinone and other still unknown substances. The addition of salicylic acid partially inhibits these inactivation processes. The soft zinc oxide paste used in the clinical trials gave results that were as good as those of a stiffer zinc oxide paste and is easier to prepare and to apply.
Some Electron-Microscopic Aspects of Pemphigus erythematosus compared to those of Pemphigus vulgaris
Authors: van de Staak W.J.B.M. , Bergers A.M.G.
Published: October 2009

1. The degree of disappearance of the desmosomes in established pemphigus erythematosus blister resembles that in an early blister in pemphigus vulgaris. One might consider pemphigus erythematosus as a pemphigus vulgaris which has remained in its initial phase. 2. The degree of disappearance of desmosomes in pemphigus erythematosus appears to be less than in pemphigus foliaceus.
Etude ultrastructurale des taches pigmentaires du syndrome d’Albright
Authors: Frenk E.
Published: October 2009

The pigmented spots on 2 patients of the Caucasian race suffering from Albright’s syndrome have been studied by optical and electron microscopy. These spots are characterized by melanin hyperpigmentation of all the layers of the epidermis without any quantitative change in the number of melanocytes. The dispersion of the melanosomes in the keratinocytes is, however, of a special type: they are dispersed in isolated elements as in the epidermis of those of the negroid race. The pigmentation of the control skin is normal.
Clinical Aspect of Pityriasis Rubra Pilaris in Childhood
Authors: Stanoeva L. , Konstantinov D. , Ristov R.
Published: October 2009

Two patients with pityriasis rubra pilaris (PRP) in childhood were observed. The affection was characterised by an acute onset and relatively short evolution. It was not noted that the disease was familiar. A focal infection of the tonsils which existed prior to the skin lesions in both cases was considered as a provocative factor. PRP of an acute onset in childhood could not be considered as special entity, but as a clinical variety of PRP and is characterised by satisfactory prognosis. Both of our cases were completely cured within 2–3 months. The therapy with penicillin and vitamin A was very effective.
Suppression of Contact Hypersensitivity to DNCB by Previous Intravenous Injection of DNP-protein Conjugate
Authors: de Wit R.F.E. , Bleumink E.
Published: October 2009

The present paper reported the suppression in guinea-pigs of contact hypersensitivity to dinitrochlorobenzene by previous intravenous injection of DNP-protein conjugate. It was observed that intravenous injection of 2.5 mg (DNP)5–10-guinea-pig serum albumin, followed by one or two intraperitoneal booster injections of 0.1 mg protein conjugate provoked detectable antibody to DNP-groups. These animals showed (as compared to normal controls) a significantly diminished capacity to develop contact hypersensitivity to DNCB on subsequent epicutaneous contact with the allergen. It is suggested that we are dealing with an antibody induced unresponsiveness.
The Ultrastructure of the Skin of Human Embryos
Authors: Hashimoto K.
Published: October 2009

Electron microscopic studies were performed on the embryonic intradermal hair canal formation in the scalp and eyebrow skin using eleven Negro embryos of the menstrual ages of 9 to 18 weeks. It was found that the intradermal hair canal was formed by cellular death of the centrally located core cells which dropped in from the stratum intermedium of the epidermis when the cells of the stratum basale bulged out and descended as the hair germ.
Kasuistischer Beitrag zur Behandlung der Urticaria pigmentosa xanthelasmoidea bullosa mit Cyproheptadin
Authors: Haneke E.
Published: October 2009

A case of Urticaria pigmentosa xanthelasmoidea bullosa with generalized vascular symptoms (flushes) is reported. Blisters already appeared at the second day of life. The daily medication of 2 times 2 mg cyproheptadine soon stopped the formation of bullae, calmed the pruritus, and the flushes disappeared. Possible interrelationships between histamine and 5-hydroxytryptamine in the symptomatology of bullous urticaria pigmentosa are pointed out in the light of the action of cyproheptadine as a combined serotonin-histamine antagonist and of methysergide as a selective antiserotonin agent, respectively.
Das Sézary-Syndrom
Authors: Ebner H. , Kühböck J. , Pietschmann H.
Published: October 2009

A 20-year-old man with Sézary-syndrome is presented. This disease is characterized by a generalized, exfoliative dermatitis, a massive enlargement of the superficial lymph nodes and a leukaemic blood count with atypical cells. Histologically the skin changes were similar to mycosis fungoides, the lymph nodes showing non-specific changes. In the peripheral blood with a leucocyte count of 30.000 atypical monocytoid (7%) and lymphocytoid (30%) cells could be differentiated. Electron microscopy revealed large cells with multilobular nuclei in the skin infiltration as well as in the peripheral blood, classified as ‘Sézary cells’. The Sézary-syndrome is a rare and special form of skin reticuloses.
Lymphadenosis Benigna Cutis: Pseudomalignant Form and its Imprint Smear Cytology
Authors: Kawada A. , Mori S. , Hayashi T.
Published: October 2009

Two cases of lymphadenosis benigna cutis or lymphocytoma showing pseudomalignant histologic features have been studied with the imprint smear method and histochemical technique for α-naphthyl esterase. The present study revealed the presence of lymphoblasts and more immature lymphocytic cells (so-called Germinoblasten and basophile Stammzellen of Lennert) as well as reticulum cells showing several variations.
Molecular Status of Plasma Fibronectin as an Additional Biomarker for Assessment of Alzheimer’s Dementia Risk
Authors: Lemańska-Perek Anna , Leszek Jerzy , Krzyżanowska-Gołą;b Dorota , Radzik Jacek , Ką;tnik-Prastowska Iwona
Published: October 2009

Background:Aberrant angiogenesis and senescence of the cerebrovascular system could initiate neurovascular events leading to neurovascular disorders. Fibronectin (FN) exerts a strong angiogenic influence on endothelial cells in the central nervous system. Methods: In the present study the expression of the plasma fibronectin molecular forms in an Alzheimer patient group, compared with vascular dementia and age-matched control groups was analyzed by immunoblotting. Results: FN in the plasma of the elderly individuals with and without dementia exists as a mixture of heterogeneous molecules with increasing molecular masses. Apart from the wide ∼240-kDa and ∼220-kDa FN bands, normally present in plasma, the high molecular FN forms having ∼280 kDa and ∼320 kDa appeared in the plasma of the Alzheimer dementia group more frequently and at the higher amounts than in the vascular dementia and age-matched nondemented groups. Conclusions: The plasma FN molecular status seems to be a molecular additional biomarker for assessment of dementia risk.
Subcortical Vascular Dementia Biomarker Pattern in Mild Cognitive Impairment
Authors: Bjerke Maria , Andreasson Ulf , Rolstad Sindre , Nordlund Arto , Lind Karin , Zetterberg Henrik , Edman Åke , Blennow Kaj , Wallin Anders
Published: October 2009

Background: Mild cognitive impairment (MCI) is an etiologically unclear disorder. Cerebrospinal fluid (CSF) biomarkers are potentially useful for the differentiation between various MCI etiologies. Aim: The aim of the study was to assess whether baseline CSF hyperphosphorylated tau (P-tau), total tau (T-tau), amyloid β 1–42 (Aβ42) and neurofilament light (NF-L) in patients with MCI could predict subcortical vascular dementia (SVD) and Alzheimer’s disease (AD) at follow-up. Methods: Biomarker levels were assessed by Luminex xMAP technology and ELISA. Results: Increased baseline concentrations of NF-L significantly separated MCI-SVD from stable MCI. The MCI-SVD patients were inseparable from stable MCI but separable from patients developing AD (MCI-AD) on the basis of Aβ42, T-tau and P-tau181 levels. Conclusion: A combination of the biomarkers Aβ42, T-tau, P-tau181 and NF-L has the potential to improve the clinical separation of MCI-SVD patients from stable MCI and MCI-AD patients.
Cardiomyopathy: A Systematic Review of Disease-Causing Mutations in Myosin Heavy Chain 7 and Their Phenotypic Manifestations
Authors: Walsh R. , Rutland C. , Thomas R. , Loughna S.
Published: October 2009

Background:Mutations in myosin heavy chain 7 (MYH7) commonly cause cardiomyopathy. However, the relationship between mutation location, cardiomyopathy type, change in amino acid composition and disease severity is poorly understood. This systematic review aims to provide, on a large scale, important insights into the role mutations in MYH7 play in cardiomyopathy. Methods: The literature was searched from 1966 to March 2009. The mutation location, type of mutation and disease type and severity were documented. When the severity of disease was known, the change in charge and hydropathy of the mutation was determined. Where appropriate, either a χ2 test was used or a relative risk ratio was calculated in order to evaluate the data. Results:The data presented in this study demonstrate that there are proportionately more mutations in the head and neck regions of this gene than in the tail. Importantly, mutations in the head of the gene, those that cause large changes in the hydropathy of the amino acid and non-conservative mutations are more likely to lead to a severe phenotype. Conclusions: This study suggests that mutation location in the MYH7 gene and changes in amino acid composition can have a negative impact on the disease outcome in individuals with cardiomyopathy.
Circulating Adiponectin: Associations with Risk Factors and the Reynolds Risk Score in Women without Prior Major Cardiovascular Events
Authors: Calomfirescu Nicoleta , Popa Calin , Jurcut Ruxandra , Serban Marinela , Ginghina Carmen
Published: October 2009

Objective: Adiponectin may play an important role in the interplay between metabolic changes and cardiovascular risks. Our aim was to establish if plasma adiponectin can be used to detect the metabolic syndrome (MetS) in women without a history of major cardiovascular events and to evaluate its correlation with the global cardiovascular risk expressed by the Reynolds risk score (RRS). Methods: 148 consecutive women without a history of cardiovascular events with or without MetS have been investigated. Clinical risks factors as well as plasma levels of lipids, fasting glucose and adiponectin were determined. Results: As expected, circulating adiponectin was lower in women with MetS: 26.8 ± 20.4 versus 44.3 ± 26.7 μg/ml (p < 0.001) and inversely related to the number of MetS features (r = –0.33, p < 0.001). The latter was further associated with the total cardiovascular risk calculated using RRS (r = 0.49, p < 0.001). However, there was no relationship between circulating adiponectin and this score (r = –0.14, p = NS). Conclusions: Plasma adiponectin levels are significantly lower in women with MetS, but as a stand-alone tool plasma adiponectin may be of little value in the diagnosis MetS. Circulating adiponectin levels are not associated with the global cardiovascular risk calculated using RRS.
Cardiac Resynchronization Induces Major Structural and Functional Reverse Remodeling in Patients With New York Heart Association Class I/II Heart Failure
Authors: St. John Sutton Martin , Ghio Stefano , Plappert Ted , Tavazzi Luigi , Scelsi Laura , Daubert Claude , Abraham William T. , Gold Michael R. , Hassager Christian , Herre John M. , Linde Cecilia
Published: October 2009

Background—

Cardiac resynchronization therapy (CRT) improves LV structure, function, and clinical outcomes in New York Heart Association class III/IV heart failure with prolonged QRS. It is not known whether patients with New York Heart Association class I/II systolic heart failure exhibit left ventricular (LV) reverse remodeling with CRT or whether reverse remodeling is modified by the cause of heart failure.

Methods and Results—

Six hundred ten patients with New York Heart Association class I/II heart failure, QRS duration ≥120 ms, LV end-diastolic dimension ≥55 mm, and LV ejection fraction ≤40% were randomized to active therapy (CRT on; n=419) or control (CRT off; n=191) for 12 months. Doppler echocardiograms were recorded at baseline, before hospital discharge, and at 6 and 12 months. When CRT was turned on initially, immediate changes occurred in LV volumes and ejection fraction; however, these changes did not correlate with the long-term changes (12 months) in LV end-systolic (
r
=0.11,
P
=0.31) or end-diastolic (
r
=0.10,
P
=0.38) volume indexes or LV ejection fraction (
r
=0.07,
P
=0.72). LV end-diastolic and end-systolic volume indexes decreased in patients with CRT turned on (both
P
<0.001 compared with CRT off), whereas LV ejection fraction in CRT-on patients increased (
P
<0.0001 compared with CRT off) from baseline through 12 months. LV mass, mitral regurgitation, and LV diastolic function did not change in either group by 12 months; however, there was a 3-fold greater reduction in LV end-diastolic and end-systolic volume indexes and a 3-fold greater increase in LV ejection fraction in patients with nonischemic causes of heart failure.

Conclusions—

CRT in patients with New York Heart Association I/II resulted in major structural and functional reverse remodeling at 1 year, with the greatest changes occurring in patients with a nonischemic cause of heart failure. CRT may interrupt the natural disease progression in these patients.

Clinical Trial Registration—

Clinicaltrials.gov Identifier: NCT00271154.