bluuebunny/crossref_metadata_2025 huggingface dataset:
The development of the solution search method based on the improved bee colony algorithm
Authors: Shyshatskyi Andrii , Ishchenko Alexander , Salnyk Serhii , Trotsko Oleksandr , Shabanova-Kushnarenko Lyubov , Velychko Vira , Kornienko Ruslan
Published: May 2023

Active digitization of people's daily life leads to the use of the decision-making support systems (DMSS). DMSS is actively used in data processing, forecasting the course of various processes, providing informational support for the decision-making process by decision makers. However, a number of problems arise while evaluating monitoring objects, namely: a large number of destabilizing factors affecting the efficiency of the processes of information collection, processing and transmission; high dynamism of changes in the state and composition of heterogeneous monitoring objects during the conduct of hostilities (operations); high dynamism of conducting hostilities (operations); the uncertainty of the initial situation and the noise of the initial data. In this article, a method of finding solutions based on an improved bee colony algorithm was developed.

The efficiency of information processing is achieved by learning the architecture of artificial neural networks; taking into account the type of uncertainty of the information to be evaluated; the use of an improved algorithm of the bee colony, the use of an unordered linguistic scale of measurements with adjustment coefficients for the degree of awareness and the degree of noise of the initial data. An approbation of the use of the proposed method was carried out on the example of assessing the state of the operational grouping of troops (forces). The method is proposed to be used in the development of software for automated systems of control of troops and weapons, namely, in the modernization of existing and development of new automated systems of control of troops and weapons. The evaluation of the effectiveness of the proposed method showed an increase in the efficiency of the evaluation at the level of 21–28 % in terms of the efficiency of information processing
ASSESMENT OF FUNCTIONAL OUTCOME OF DUAL PLATING FOR COMMINUTED DISTAL FEMUR FRACTURE
Authors: Pandey K.K , Vidyarthi Ashok , Kumar Cholak Naveen
Published: May 2023

Background-Distal femur fractures are commonlyassociated with severemetaphysealcomminution and significant soft tissue injury.Locking plating is one of the best and modern options for treating supracondylar femur fractures with relatively low failure rates. Single lateral plating of distal femur fractures was often found to have a relatively higher failure. A medial platingin addition to lateral plating reduces the chances of failure of fixation and prevents varus collapse.The purpose of this study is toAssessment of Functional Outcome of Dual Plating For Comminuted Distal Femur Fracture. Materials and Methods-Following ethical approval, thirty patients with distal femur fractures were treated with dual plating between 1st January 2021 to 31st June 2022.The follow-up studies included clinical and radiographic examinations. All relevant outcomes were recorded during follow-up. Result-All 30 patients were assessed by follow-ups. All follow-up fracture united by the end of study, but delayed union was observed in 5/30 patients. The average union time is 6.2 months (range, 5 to 8 months). The main complication in this study was found to be surgical site infection which occupied 6/30 cases. Conclusion-In our study though there were complications and increase in operating time, the union rate is 100% with no varuscollapse or malunion and functional range of movements were good in 40% of cases and excellent in 25% cases, so double plating is one of the betteroptionto achieve bony union and better functional outcome in severely comminuted distal femur fractures.
A STUDY ONANTI-MICROBIAL RESISTANTENVIRONMENTAL BACTERIA FROM AURANGABAD CITY MUNICIPAL AREA MAHARASHTRA, INDIA
Authors:   School of Environmental and Earth Sciences, KavayitriBahinabai Chaudhari North Maharashtra University, Jalgaon (M.S.) India., S. Thorat Abhijit , B. Attarde Sanjay ,   School of Environmental and Earth Sciences, KavayitriBahinabai Chaudhari North Maharashtra University, Jalgaon (M.S.) India.
Published: May 2023

With rapid industrial development and progress of civilization, the problem of increase in waste generation becomes more complex in urban areas like Aurangabad fastest growing city in Asia in Marathwada, Maharashtra in India. In this study,we explorethe diversityofbacteriainsewagewastewater withthe assessment oftheantibiotic resistance of the isolated bacteria. The water samples: sewage wastewater was collectedfrominaround the Aurangabad City of Maharashtra, India, and was processed for isolation, which was characterized for identificationfollowingphenotypictechniques.A total of 09 bacteria were isolated from the sewage samples studied, among which 3 were gram-negative and 06 were gram-positive. Our present study evidently revealed that thesewageasconfirmedinthecurrentstudy,the growth ofgram-positive rods shape cocci, and evengram-negative rods too in which the diversity of gram-positivebacteria was found greater, as we compared to the gram-negative bacteria.Thesebacteria isolateshave the potential to cause infections andpossess varied antibiotic resistance. Thus,thisisimperativefortheregularvigilanceofsuchwastewaterbacteriatocombatbacterialmultipleantibioticresistance. We can conclude that the useful bacteria might be isolated from the Aurangabad city area which will be helpful for bioconversion of sewage/solid waste management.
A MECHANISM FOR IMPROVING PROFESSIONAL TRAINING OF FUTURE SPECIALISTS BASED ON AN INTEGRATIVE DEVELOPMENTAL APPROACH
Authors:   Doctorate Researcher Tashkent State University of Economics Islam Karimov Street 49 100066 Tashkent, Uzbekistan., Maxfuza Maxsumova
Published: May 2023

The aim of the investigation is development of innovative strategyof quality control training of engineers and skilled workers (hereinafter ÃƒÂƒÃ‚Â¢ÃƒÂ‚Ã‚Â€ÃƒÂ‚Ã‚Â“ futurespecialists) in educational professional organizations on the principles of socialpartnership. Methods: Theoretic: theoretic and methodological analysis, polytheoreticsynthesis, modeling. Empirical: research and generalization of the system, processand competence ÃƒÂƒÃ‚Â¢ÃƒÂ‚Ã‚Â€ÃƒÂ‚Ã‚Â“ based approaches experience, experiment, observation,surveys, expert evaluation, SWOT-analysis as a method of strategic planningwhich is to identify the internal and external factors (socio-cultural) of the organizationsurrounding. Results: The strategy of the development of the process of quality controltraining in educational professional organizations and a predictive model of thesystem of quality control training for future engineers and workers have been createdon the analysis and synthesis of a quantitative specification of the quality, the obtained experience and success in control training of future specialists ineducational professional organizations in recent economic and educational conditions. Scientific novelty: There has been built a predicative model of quality controltraining of future specialists to meet modern standards and the principles of socialpartnership the control algorithm of the learning process, developed in accordancewith the standards (international) of quality ISO in the implementationof the quality control systems of the process approach (matrix-based responsibility,competence and remit of those responsible for the education process in theeducational organization, the ÃƒÂƒÃ‚Â‚ÃƒÂ‚Ã‚Â«problemÃƒÂƒÃ‚Â‚ÃƒÂ‚Ã‚Â» terms and diagnostic tools for assessingthe quality of professional training of future specialists). The perspective directionsof innovation in the control of the quality of future professionals traininghave been determined the parameters of a comprehensive analysis of the state ofthe system to ensure the quality of their training on the basis of procedures forself-examination and questioning have been supported the improving systemtechnology to ensure the quality of vocational training have been developed theimplementation mechanism of the system of quality training control training offuture specialists in the professional organization have been specified. Practical Significance: The obtained results exploitation in educational practicecan improve the effectiveness of the innovative development of the qualitycontrol training system of future specialists in educational organizations.
PANCREAS DISEASE DETECTION AND SEGMENTATION USING ABDOMINAL CT SCAN
Authors:   SRMIST, Ghaziabad, UP., Chaudhary Richa , Jain Shruti ,   SRMIST, Ghaziabad, UP., Maroju Keerthi ,   SRMIST, Ghaziabad, UP., Malik Anjali ,   Assistant Professor, Department of CSE, SRMIST, Ghaziabad, UP.
Published: May 2023

Anomalies in the pancreas regional morphology and texture may now be examined by accurately segmenting the organs head, body, and tail on CT images. Hand-drawn pancreatic subregion mapping is labor-intensive, slow, and prone to mistakes. For the zonal segmentation of various anatomical properties, many deep learning networks have been utilized in the present approaches. The three subregions are almost ever visible together in the two-dimensional CT abdominal slices, which limits how the contextual data may be used by the current methods. In this study, we offer a multistage method that uses CT images of pancreatic subregions to accurately and automatically segment 3D objects. The U-Net model is then used to calculate the combined probability of the two maps to perform the best sub regional segmentation. The datasets D1 and D2 of contrast-enhanced abdominal CT images were used to assess the models performance together with a healthy pancreas from the public NIH dataset.
HYPER IGM SYNDROME: ABOUT 2 CASES
Authors:   Pediatric Infectiology and Immunology Care Department, Mohammed VI University Hospital and Research, Morocco., Mahir Nahid ,   Child Health and Development Research Laboratory, Marrakech school of Medicine Cadi., ELfakiri K. ,   Pediatric Infectiology and Immunology Care Department, Mohammed VI University Hospital and Research, Morocco.,   Child Health and Development Research Laboratory, Marrakech school of Medicine Cadi., Drais Gh. ,   Pediatric Infectiology and Immunology Care Department, Mohammed VI University Hospital and Research, Morocco.,   Child Health and Development Research Laboratory, Marrakech school of Medicine Cadi., Rada N. ,   Pediatric Infectiology and Immunology Care Department, Mohammed VI University Hospital and Research, Morocco.,   Child Health and Development Research Laboratory, Marrakech school of Medicine Cadi., Bouskraoui M. ,   Pediatric Infectiology and Immunology Care Department, Mohammed VI University Hospital and Research, Morocco.,   Child Health and Development Research Laboratory, Marrakech school of Medicine Cadi.
Published: May 2023

Hyper-IgM syndrome is a rare combined immune deficiency linked to a mutation most frequently found in CD40.The diagnosis is usually made in the presence of recurrent infections, particularly pulmonary, digestive and others. Through to the dosage of lymphocyte subpopulations and after elimination of other differential diagnoses, the diagnosis of hyper-IgM syndrome can be confirmed. The objective of this work is to emphasize the presence of the diagnosis of hyper-IgM syndrome, the interest to search for it to avoid the repercussions on the growth especially and the survival. Results: We reported the case of 2 patients the first one a 4 years old patient diagnosed at the stage of complication by a DDB which presented infections essentially pulmonary with repetition in front of this table a dosage of immunoglobulins was required which was in favor of syndrome of hyper-IgM. And a second one the 10 years old, this patient who had as history a brother who died of the same symptomatology, repeated ear infections, digestive infections such as gastritis with HP a zona the immunoglobulin dosage objectified a hyper-IgM syndrome. Both patients were put under immunoglobulins with good evolution. Conclusion: The hyper IgM syndrome is still rare but should be suspected as any immune deficiency in front of repeated infections. We have illustrated in this work two cases that have evolved well with treatment and how certain complications can be avoided by early diagnosis.
CREDIT CARD FRAUD DETECTION USING MACHINE-LEARNING
Authors:   Dept of ISE, RYM Engineering College, Ballari., M.S Prateeksha , Naga Swetha B. ,   Dept of ISE, RYM Engineering College, Ballari., Patil Manjula ,   Professor, Dept of ISE, RYM Engineering College, Ballari.
Published: May 2023

The recent advances of e-commerce and e-payment systems have sparked an increase in financial fraud cases such as credit card fraud. It is therefore crucial to implement mechanisms that can detect the credit card fraud. Features of credit card frauds play important role when machine learning is used for credit card fraud detection, and they must be chosen properly. This paper proposes a machine learning (ML) based credit card fraud detection engine using ML classifiers: Decision Tree (DT), Logistic Regression (LR), Artificial Neural Network (ANN). To validate the performance, the proposed credit card fraud detection engine is evaluated using a dataset generated from European cardholders. The result demonstrated that our proposed approach outperforms existing systems.
FACTORS AFFECTING FUNCTIONAL OUTCOME OF DISTAL TIBIA FRACTURES TREATED BY PLATING USING MINIMAL INVASIVE PERCUTANEOUS PLATE OSTEOSYNTHESIS TECHNIQUE
Authors: Shukla Rajeev , Masand Narayan , Singh Verma Nishant , Jain Sparsh , Keshav Abhishek , Pingle Pravishi , Mehta Deepesh
Published: May 2023

Introduction: Minimally invasive plate osteosynthesis (MIPO) is an established technique for fixation of fractures of the distal third tibia. Minimally invasive plating offers the advantage of fracture fixation without disturbing the soft tissue cover, less chances of infection, early mobilization of patient. Using a locking compression plate reduces the tendency for varus collapse and at the same time affords better stability Our study aimed to manage intra articular and extraarticular fractures of the distal third tibia by the minimally invasive plate osteosynthesis technique and follow them. Clinical and radiological outcomes were studied, and clinical indications & efficacy of the procedure reviewed. Materials and Methods: An ambispective analysis of 30 patients of closed distal tibial fractures were operated by MIPO technique. Bone and soft tissue healing and complications encountered were analyzed. Result: It has been a well-known fact that distal tibia fractures have recently been treated by minimally invasive techniques. Literature above says that there is risk of disrupting blood supply with open reduction internal fixation leading to soft tissue healing problems. However, we did not face any of these complications in our patients, infection or wound breakdown with implant exposure. Conclusion: Distal tibial fractures can successfully be treated by single stage MIPPO plating. Considering a proper surgical timing, respect for soft tissue handling, a good fixation can be achieved. Minimally Invasive Osteosynthesis of distal tibial fracture produced reliable results with acceptable range of movement and resuming early return to activities of daily living.
ASSESSMENT OF HIP INSTABILITY IN HIGH RISK DELIVERIES IN NEWBORN BY CLINICAL EXAMINATION AND ULTRASONOGRAPHY
Authors: Jain Arjun , Mandlecha Pushpvardhan , Bansal Sanjul , Kaushik Dhruv
Published: May 2023

Background: Developmental dysplasia of hip (DDH) is one entity which occasionally comes across in orthopaedic or paediatric outpatient department. The knowledge of risk factors and awareness of the condition is must for every orthopaedic surgeon and paediatrician so that the diagnosis wonÃ‚Â’t be missed. An early diagnosis can alter the prognosis of the disease and prevent late disabilities. Material And Methods: Diagnosis of instability in the neonatal period can be easily assessed with the Barlow and Ortolani manoeuvres. Sonography is valuable in the first months of life. Graf et al established a method to evaluate the infant hip according to morphology. Result: It has been found that first born female with breech presentation has more chances of this hip instability as compare to male born with left side more affected assessed by clinically and graf et al method. Conclusion: Neonatal hip instability is common and a screening programme should be initiated to detect its incidence and prognosis can be better if diagnosed early.
Agrobacterium rhizogenes-Mediated Transformation of Crotalaria ochroleuca: Production of Flavonoids from Hairy Roots
Authors: Blank Daiane , Demuner Antonio , Carvalho Jilma , Firmino Maria , Figueiredo Tainá , Souza Gustavo , Zocolo Guilherme , Guedes Jhonyson , Faria Daniele , Vieira Lorena , Soares Jéssica , Fortini Evandro , Santos Marcia , Otoni Wagner
Published: May 2023

Crotalaria ochroleuca (Fabaceae) is rich in bioactive compounds used for nematode control. Transformed root culture allows the production of a large amount of hairy root biomass, conditioned by auxin biosynthesis-related genes integrated via the process of Agrobacterium rhizogenes infection, which is known to cause a hairy root phenotype. We transformed A. rhizogenes to increase the biomass of hairy roots and optimized the process of production of bioactive compounds. The transformed nature of hairy roots was confirmed by polymerase chain reaction, which confers kanamycin resistance. The transformed roots were cultured in full-strength in liquid media to realize the growth of hairy roots and the production of bioactive compounds. The transformed roots were grown in a culture medium supplemented with elicitors to produce total phenols, and flavonoids. Chromatographic analysis of transformed roots revealed the presence of flavonoids apigenin-6,8-C-diglucoside and luteolin-6-C-glucoside. The results were obtained by conducting physiological and biochemical studies with the flavonoids and studying the pathways that led to the production of large amounts of bioactive compounds from the hairy roots of C. ochroleuca. It was observed that the extraction of the compounds significantly affected nematodes and insect larvae, resulting in significantly high levels of economic damage to crops.
conservadorismo na sociologia de Florestan Fernandes
Authors: Dos Santos Gomes Junior Elson
Published: May 2023

O presente artigo apresenta uma análise das críticas endereçadas ao conservadorismo pelo sociólogo paulista Florestan Fernandes (1920-1995). Sendo uma das principais vertentes do pensamento político moderno ao lado do liberalismo e do socialismo, o conservadorismo tem sido estudado comumente através de reiterações e de reforços aos seus pressupostos como, por exemplo, o apego constitucional, a valorização da desigualdade como uma forma de incentivo, a perspectiva ontológica pautada na ideia de corpo e alma e a valorização da liberdade de propriedade. Florestan, tomando o escopo do conservadorismo como contraponto, o desconstrói apresentando como alternativa elementos como a condição humana, o radicalismo democrático, a formação humana e a necessidade de uma sociedade civil civilizada. Além do proposto, o presente estudo preenche uma lacuna temática nos estudos desenvolvidos sobre o autor até o presente momento.
ANAIS III CIOI - CONGRESSO INTERNACIONAL DE ODONTOLOGIA INNOVATION
Authors: Freitas Amílcar , Almeida Érika Oliveira de , Galvao Cecília Santos
Published: May 2023

Nos dias 2 a 4 de junho de 2022 ocorreu a 3a edição do Congresso Internacional de Odontologia Innovation (CIOI), reunindo 940 participantes no Centro de Convenções de Natal-RN. Foram 3 dias de muita atualização nas diferentes áreas da Odontologia, contando com 52 palestras e 12 hands-on com professores de 5 países. Além disso, foram apresentados 175 trabalhos científicos por profissionais e acadêmicos de Odontologia de todas as regiões do Brasil, especialmente do Nordeste.

O CIOI é um evento de natureza multidisciplinar, com ênfase em ciência, tecnologia e inovação, sendo de grande importância para a odontologia potiguar por compartilhar experiências de profissionais internacionais, nacionais e acadêmicos, com a intenção de expor resultados de pesquisas científicas aliados a experiência clínica dos mesmos de forma a desenvolver sendo crítico e reflexivo sobre vários planejamentos e tratamentos dentro da odontologia.

Nessa 3a edição, tivemos o 1a Meeting de Implantodontia do Norte Nordeste, 1a Meeting de Odontologia digital e 1a Meeting Brasileiro de Harmonização Orofacial, além de professores das áreas de periodontia, reabilitação oral, dentística, cirurgia buco-maxilo-facial, endodontia, pacientes especiais, patologia e estomatologia, marketing, odontologia social e técnicos em prótese dentária. Foi um evento muito especial e importante para a odontologia potiguar. Gostaríamos de agradecer a presença de todos, incluindo os palestrantes, colaboradores, empresas e todos os congressistas que confiaram no nosso evento.
AMBIENTES DE TRABALHO INTERAÇÃO E TERRITORIALIDADE PARA AS GERAÇÕES EMERGENTES
Authors: Bussi Luize Andreazza , Almeida Maristela Moraes de
Published: May 2023

Os ambientes voltados para o trabalho são locais de grande importância na vida urbana, onde o indivíduo adulto passa cerca de um terço das horas do dia e desenvolve-se intelectualmente e em suas habilidades sociais. Com a Pandemia da Covid-19, algumas mudanças se fizeram necessárias, exigindo que os profissionais tentassem adaptar locais inadvertidamente, conforme as premissas sanitárias. Esta migração do sistema presencial (escritórios) para o sistema de Home Office, trouxe consigo alguns problemas ergonômicos e técnicos para o cumprimento das tarefas laborais. Com o objetivo de Entender como se manifesta a territorialidade em espaços colaborativos de escritórios durante o período da pandemia por parte das gerações emergentes (Millennials e Geração Z), se deu esta pesquisa. Para tanto inicialmente apresenta-se uma contextualização bibliográfica, embasada na Psicologia Ambiental e na Fenomenologia, a fim de explicarem-se brevemente os conceitos de território, territorialidade e apropriação do espaço. Num segundo momento apresenta-se uma pesquisa de campo com um grupo de trabalhadores das gerações citadas, que utiliza como método a técnica de “Grupo Focal”. O resultado trouxe à tona princípios importantes para os projetistas que pretendem basear seus trabalhos na dinâmica territorial dos novos usuários de escritórios. Com tais valores elucidados, apresentaram-se também alguns diagramas com sugestões para atendimento destas novas demandas.
Da ideia ao projeto urbano, um estudo de caso
Authors: Macedo Adilson
Published: May 2023

O Corredor Cultural da Mooca, CCM, é uma ideia que poderá vir a ser um projeto urbano. Situa-se na cidade de São Paulo, no distrito que lhe empresta o nome. Possui forte identidade local, diversificada ocupação do espaço e estrutura coesa à espera de iniciativa que vá além da transformação de parcelas industriais em condomínios fechados, a simples preservação dos bens históricos, ajustes do viário ou zoneamento. O CCM induzirá melhoras na qualidade ambiental a partir do sistema integrado dos elementos urbanos, dos tipos edificados, ajustes locacionais, o aumento dos espaços livres, conforto para as pessoas circularem; a pé, em veículos individuais ou transporte público. A implementação do projeto será possível através de uma empresa de urbanização de gerenciamento privado, formada por parceiros locais e outros de fora, discreta participação da municipalidade, das entidades de proteção ambiental, do patrimônio histórico e infraestrutura. Apresentarei uma maneira de iniciar o projeto como ‘urban design’ e nele o enfoque pelo viés da viabilidade se cruza com as questões conceituais relativas aos elementos urbanos, a participação das pessoas e a compreensão pelo arquiteto andando a pé, observando os espaços e ouvindo opiniões. A área do CCM é de vinte e dois hectares.
Natural Amphibian-Derived Host Defense Peptides: Peptide Immunomodulators
with Potential Therapeutic Value
Authors: Shi Jie , Wu Jing , Feng Guizhu , Yang Hailong , Mu Lixian
Published: May 2023

Due to the rapid evolution of bacterial drug resistance, anti-infective treatment has become
a global problem. Therefore, there is an urgent need to develop alternative treatment strategies. Host
defense peptides (HDPs) are important components of the natural immune system and are widely
distributed in the animal and plant kingdoms. Amphibians, especially their skin, provide a rich source
of natural HDPs encoded by genes. These HDPs exhibit not only broad-spectrum antimicrobial
activity but also a wide range of immunoregulatory characteristics, including modulation of antiinflammatory
and proinflammatory reactions, regulation of specific cellular functions, enhancement of
immune chemotaxis, regulation of adaptive immunity, and promotion of wound healing. They also
show potent therapeutic effects on infectious and inflammatory diseases caused by pathogenic
microorganisms. Thus, in the current review, we summarize the extensive immunomodulatory
functions of natural amphibian HDPs, as well as the challenges of clinical development and potential
solutions, which have important implications for the development of new anti-infective drugs.
Pyrazolo[4,3-H]quinazolines as Cyclin-dependent Kinase Inhibitors
for Treating Cancer
Authors: De Surya K.
Published: May 2023

The application describes the synthesis of 1H-pyrazolo[4,3-H]quinazoline
compounds for treating cell proliferation dysfunction and is a broad-spectrum and strongly-
active inhibitor for a cell cyclin-dependent kinase (CDK).
In silico Molecular Docking Analysis of Three Molecules Isolated from
Litsea guatemalensis Mez on Anti-inflammatory Receptors
Authors: Peralta Lucrecia , Vásquez Allan , Marroquín Nereida , Guerra Lesbia , Cruz Sully M. , Cáceres Armando
Published: May 2023

Background:

The Litsea genus has four native species from Mesoamerica. Litsea guatemalensis
Mez. is a native tree, traditionally used as a condiment and herbal medicine in the region.
It has demonstrated antimicrobial, aromatic, anti-inflammatory and antioxidant activity. Bioactive
fractionation attributed the anti-inflammatory and anti-hyperalgesic activities to pinocembrin, scopoletin,
and 5,7,3´4´-tetrahydroxy-isoflavone. In silico analysis, these molecules were analyzed on
receptors involved in the anti-inflammatory process to determine which pathways they interact.

Objective:

To analyze and evaluate 5,7,3',4'-tetrahydroxyisoflavone, pinocembrin, and scopoletin
using the in silico analysis against selected receptors involved in the inflammatory pathway.

Method:

Known receptors involved in the anti-inflammatory process found as protein-ligand complex
in the Protein Data Bank (PDB) were used as references for each receptor and compared with
the molecules of interest. The GOLD-ChemScore function, provided by the software, was used to
rank the complexes and visually inspect the overlap between the reference ligand and the poses of
the studied metabolites.

Results:

53 proteins were evaluated, each one in five conformations minimized by molecular dynamics.
The scores obtained for dihydroorotate dehydrogenase were greater than 80 for the three
molecules of interest, scores for cyclooxygenase 1 and glucocorticoid receptor were greater than 50,
and identified residues with interaction in binding sites overlap with the reference ligands in these
receptors.

Conclusion:

The three molecules involved in the anti-inflammatory process of L. guatemalensis
show in silico high affinity to the enzyme dihydroorotate dehydrogenase, glucocorticoid receptors
and cyclooxygenase-1.
Biological Effects and Mechanisms of Taurine in Various Therapeutics
Authors: Sharma Shikha , Sahoo Biswa Mohan , Banik Bimal Krishna
Published: May 2023

More than two hundred years ago, taurine was first isolated from materials derived from animals.
It is abundantly found in a wide range of mammalian and non-mammalian tissues and diverse
environments. Taurine was discovered to be a by-product of the metabolism of sulfur only a little over
a century and a half ago. Recently, there has been a renewed academic interest in researching and exploring
various uses of the amino acid taurine, and recent research has indicated that it may be useful
in the treatment of a variety of disorders, including seizures, high blood pressure, cardiac infarction,
neurodegeneration, and diabetes. Taurine is currently authorised for the therapy of congestive heart
failure in Japan, and it has shown promising results in the management of several other illnesses as
well. Moreover, it was found to be effective in some clinical trials, and hence it was patented for the
same. This review compiles the research data that supports the prospective usage of taurine as an antibacterial,
antioxidant, anti-inflammatory, diabetic, retinal protective, and membrane stabilizing agent,
amongst other applications.
Potential Aromatase Inhibitors from Centella asiatica with Non-synonymous
SNPS - A Computational Approach
Authors: Temkar Sheshadri S , Sridhara Amruta , Mallur Dhrithi Jayasimha , Shivaprakash Deepak Ishwara , Iyengar Divya , Das Nritam , C Benedict Paul
Published: May 2023

Background:

Aromatase inhibitors are used in the treatment of breast cancer as they
are effective in decreasing the concentration of estrogen. As SNPs impact the efficacy or toxicity
of drugs, evaluating them with mutated conformations would help in identifying potential inhibitors.
In recent years, phytocompounds have been under scrutiny for their activity as potential inhibitors.

Objective:

In this study, we have evaluated Centella asiatica compounds for their activity on aromatase
with clinically significant SNPs: rs700519, rs78310315 and rs56658716.

Methods:

Using AMDock v.1.5.2, which uses the AutoDock Vina engine, molecular docking
simulations were carried out, and the docked complexes were analyzed for their chemical interactions
such as polar contacts using PyMol v2.5. The mutated conformations of the protein and force
field energy differences were computationally derived using SwissPDB Viewer. PubChem,
dbSNP and ClinVar databases were used to retrieve the compounds and SNPs. ADMET prediction
profile was generated using admetSAR v1.0.

Results:

Docking simulations of the C. asiatica compounds with the native and mutated conformations
showed that out of the obtained fourteen phytocompounds, Isoquercetin, Quercetin and
9H-Fluorene-2-carboxylic acid were able to dock with best scores in terms of binding affinity (-
8.4kcal/mol), Estimated Ki (0.6 μM) values and Polar Contacts in both native and mutated conformations
(3EQM, 5JKW, 3S7S).

Conclusion:

Our computational analyses predict that the deleterious SNPs did not impact the molecular
interactions of Isoquercetin, Quercetin and 9H-Fluorene-2-carboxylic acid, providing better
lead compounds for further evaluation as potential aromatase inhibitors.
Molecular Docking and Molecular Dynamics Simulation of New Potential
JAK3 Inhibitors
Authors: Zhong Qidi , Qin Jiarui , Zhao Kaihui , Guo Lihong , Li Dongmei
Published: May 2023

Introduction:

JAK3 kinase inhibitor has become an effective means to treat tumors and autoimmune diseases.

Methods:

In this study, molecular docking and molecular dynamics simulation were used to study the theoretical interaction mechanism between 1-phenylimidazolidine-2-one molecules and JAK3 protein

Results:

The results of molecular docking showed that the six 1-phenylimidazolidine-2-one derivatives obtained by virtual screening were bound to the ATP pocket of JAK3 kinase, which were competitive inhibitors of ATP, and were mainly bound to the pocket through hydrogen bonding and hydrophobic interaction. Further, MM/GBSA based on molecular dynamics simulation sampling was used to calculate the binding energy between six molecules and the JAK3 kinase protein. Subsequently, the binding energy was decomposed into the contribution of each amino acid residue, of which Leu905, Lys855, Asp967, Leu956, Tyr904, and Val836 were the main energy-contributing residues. Among them, the molecule numbered LCM01415405 can interact with the specific amino acid Arg911 of JAK3 kinase, suggesting that the molecule may be a selective JAK3 kinase inhibitor. The root-mean-square fluctuation (RMSF) of JAK3 kinase pocket residues during molecular dynamics simulation showed that the combination of six new potential small molecule inhibitors with JAK3 kinase could reduce the flexibility of JAK3 kinase pocket residues

Conclusion:

These findings reveal the mechanism of 1-phenylimidazolidine-2-one derivatives on JAK3 protein and provide a relatively solid theoretical basis for the development and structural optimization of JAK3 protein inhibitors.
Histopathologic Examination of Ovarian Lesions: A Prospective Observational Study in Women from Central India
Authors: Saxena Somya , Singh Rajender , Patidar Harshul , Bhagora Ringku , Khare Vivek
Published: May 2023

Background: There is age related increase in the incidence of ovarian cancer. Most Indian population-based cancer registries have reported a gradual rise in the ovarian cancer incidence over the years. Since ovary is composed of totipotent gametocytes and multipotent mesenchymal tissues, almost any type of tumor can arise from these tissues. Therefore, their proper recognition and classification is important for appropriate therapy and better prognosis.Aim: to look at the histopathological profile of various ovarian lesions in the local female subjects from central India.Methods: A prospective observational study was carried out on the surgically resected ovarian samples that were referred to the Pathology department over two and half year. A total of 100 ovarian cases were included. Histopathological examination of the specimen was done using standard protocols.Results: On gross examination, majority of non-neoplastic specimen showed unremarkable findings. Microscopic examination of non-neoplastic cases revealed that most of the cases were of follicular cyst followed by corpus luteum cyst. On the contrary, majority of neoplastic specimen showed cystic external surface on gross examination. Surface epithelial tumor was the most common histologic type amongst neoplastic cases. Most common histologic subtype amongst the surface epithelial tumors was found to be benign simple serous cystadenoma. Conclusion: In women from central India, commonest non-neoplastic lesion of ovary is follicular cyst whereas most common neoplastic lesion is surface epithelial tumor (benign simple serous cystadenoma).
The Dietary Sugars Intake: The Role In Alzheimer’s Disease Pathomechanism
Authors: Rifka Wangiana Yulia Putri  , Dwi Pratika Anjarwati  , Damar Mashkhun Rizqi
Published: May 2023

Alzheimer’s disease is a common neurodegenerative disease that affect elderly and it became a serious global burden for years. Despite many studies have been performed, an effective cure for Alzheimer’s was still not be found. Therefore, it is necessary to not only focus on curative methods but also preventive methods with modifiable risk factors and underlying disease, for example lifestyle and metabolic disease, as potential approach in Alzheimer’s disease prevention in the future. The excessive dietary sugar intake has been suggested as a risk factor of many diseases such as metabolic disease and cognitive impairment disease. It may promote cognitive declines through some pathways such as induce alteration of gut microbiomes, metabolism and immune system. These abnormal processes may evoke amyloid β plaque formation and neurofibrillary tangles in brain cells as the effect of chronic inflammation. Chronic inflammation has been widely studied as the hallmark of Alzheimer’s disease pathology. Therefore, the correlation between dietary sugar and impairment cognitive, specifically Alzheimer’s disease will be summarized.
Financiële concentratie en regionaal-economische ontwikkeling in België
Authors: Goorden Lieve
Published: May 2023

Zowel sommige neoklassieke analyses van regionaal-economische verschillen tussen Wallonie en Vlaanderen als de marxistische benadering die A. Roosens en M. Quévit voorstellen hebben - hoe verschillend hun werkwijze ook moge zijn - toch een punt van kritiek gemeen : de redenering wordt ten dele opgebouwd vanuit het belang van de eigen regio waartoe de verschilfende auteurs behoren.
Er wordt een historisch-institutioneel perspectief vooropgesteld dat de opbouw van financiële en industriële groepen bekijkt vanuit interactie met specifieke historische marktomstandigheden. De overgang wordt geschetst van regionaal gedecentraliseerde bankstructuren, die de garantie inhielden van een potentieel evenwichtige subregionale expansie, naar regionaal en organisatorisch sterk gecentraliseerde financiële structuren waardoor de polarisering van Antwerpen t.o.v, de overige gewesten een feit wordt.
Het financiële kapitaal zal zich steeds minder binden aan een bepaalde ruimte. Daartegenover staat het meer recente gegeven dat groepsstructuren expliciet gaan refereren aan de regio van inplanting van hun produktie-eenheden en de KMO zullen zien als meer actieve partner binnen een losser groepsverband.
Systematisch onderzoek van die actuele institutionele ontwikkelingen kan een bijdrage leveren tot de herformulering van opties voór een nieuw Vlaams industrieel beleid.
Elementen voor een algemene theorie van verzuiling
Authors: Hellemans Staf
Published: May 2023

Zuilen zijn een modern fenomeen; hun hoogtepunt situeert zich tussen 1900 en 1960; vooral katholieken en socialisten neigen tot verzuiling; verzuiling is niet in alle staten van belang. Met de begrippen "sociale beweging" en "functionele differentiatie" wordt gepoogd om al deze verschillende aspecten te integreren in een algemene theorie van verzuiling. Sociale bewegingen vormen de bewegende achtergrond waartegen zuilen zich als netwerken van organisaties verheffen. Door functionele differentiatie, waarmee de essentie van het moderniseringsproces van onze westerse samenleving wordt aangeduid, kunnen binnen sommige sociale bewegingen netwerken van domeinspecifieke organisaties groeien. In een voortgezet stadium leidt ditzelfde proces tot manifeste ontzuiling (organisaties en zuilleden verlaten de zuil) en latente ontzuiling (transformatie van de zuil tot een neo-corporatief conglorneraat). Daarmee behoren zuilen en verzuiling tot een op zijn einde lopend tijdvak.
De sociologen en de verzuiling: over nut van deterministische en strategische paradigmata
Authors: Dierickx Guido
Published: May 2023

De deterministische paradigmata die tot op heden het onderzoeksveld voor de verzuiling beheersen vertonen een tendens naar een afnemend grensnut. Hun heuristische zwakheid leidt tot de verwaarlozing van minder conventionele hypotheses. Voor het empirisch onderzoek betekent dit een verlies aan vernieuwing en een winst aan trivialiteit. Een tweede zwak punt aan deze paradigmata volgt uit hun haast exclusieve belangstelling voor de beschrijving van factoren die op een of andere manier verband houden met de te verklaren verschijnselen. Zulke beschrijving houdt evenwel nog geen verklaring in waarom en hoe deze factoren een invloed zouden hebben op de menselijke actoren. Deze beschrijvende optiek laat de deur open voor de pseudo-evidenties van deterministische interpretaties. In deze bijdrage wordt gepleit voor het gebruik van “strategische” paradigmata zoals die voorgesteld werden door N. Elias en R. Boudon en, meer in het algemeen, door de interactionistische benadering. Zij nemen als uitgangspunt de strategieën van de betrokken actoren waarin de factoren een verstaanbare plaats innemen. Zodoende kunnen deze factoren in een verklarend en niet enkel in een beschrijvend perspectief gebezigd worden. De strategische paradigmata kunnen ook meer complexe verschijnselen verklaren (zoals, bij voorbeeld, de selectieve ontzuiling en de coalitievorming tussen ideologische organisaties) die de deterministische paradigmata onmondig laten.
Actoren en structuren in de sociologie van Giddens en Habermas
Authors: Ruebens Martin
Published: May 2023

In hun maatschappijtheorie behandelen A. Giddens en J. Habermas beiden de controverse tussen handelingstheoretische en systeemtheoretische benaderingen in de sociologie. Hun theorie tracht dit dualisme te overbruggen. Vanuit een herformulering van de begrippen 'systeem', 'structuur' en 'handelen’ argumenteren Giddens en Habermas dat actoren en structuren niet los van elkaar kunnen begrepen worden. Giddens gaat hierin het verst door 'handelen' en ' structuren' niet langer als onderscheiden werkelijkheidsdomeinen op te vatten. In hun theorie hechten ze beide een bijzonder belang aan de inbreng van recente, interpretatieve sociologieën. Hierdoor verschijnt bij Giddens en Habermas de actor als een intentioneel en competent handelend persoon die op een reflexieve wijze zijn gedrag beheerst. Toch meent Habermas functionele samenhangen te kunnen onderscheiden die door de actoren binnen de horizon van hun alledaagse leven niet kunnen waargenomen worden.
Problemen rond het thema "publieke godsdienst"
Authors: Laeyendecker Leo
Published: May 2023

The topic of Civil Religion as introduced by Robert N. Bellah - which can be described as any set of beliefs and rituals, related to the past, present and/of future of a nation - has widely met response. This probably is because it deals with Issues such as the legitimacy of the political process, the legitimacy of societal institutions and the meaning and destiny of society, issues widely felt as problematic. The topic has also been criticized, it then is interpreted as an uncritical justification of the state's power, as a remainder and parasite of christianity. The value of these criticisms is examined here as well as other, theoretical, criticisms which suggest that the argument is based on an inadequate model of society, i.e, the consensus model. In the end, some questions for research are raised in brief.
Het collectief geheugen
Authors: Elchardus Mark
Published: May 2023

Het boek La mémoire collective dat in 1950 bij de Presses Universitaires de France verscheen, bundelde de vier hoofdstukken die Maurice Halbwachs bij zijn overlijden in manuscriptvorm had achtergelaten. Zij waren reeds eerder, in 1948, door toedoen van Georges Gurvitch gepubliceerd onder de titel Mémoires et sociétés in de reeks van L'année sociologique (3e série, 1940-1948). In 1950 verschenen zij onder de naam, La mémoire collective, die Maurice Halbwachs zelf had gegeven aan de bundel papieren waaruit de hoofdstukken werden gehaald. Van die bundel werden enkel een zeer beperkt aantal erg onafgewerkte bladzijden niet gepubliceerd. Hun plaats in het manuscript wordt duidelijk aangegeven in de uitgave van de Presses Universitaires de France. De titels van de hoofdstukken zijn van Maurice Halbwachs zelf, de tussentitels werden door de redacteurs van die publikatie toegevoegd. In 1968 verscheen bij de Presses Universitaires de France een nieuwe uitgave. Deze volgt volledig deze van 1950, behalve dat in bijlage nu ook het artikel La mémoire collective chez les musiciens wordt opgenomen, dat nog tijdens het leven van Maurice Halbwachs was verschenen in de Revue philosophique (1939, 3-4). De hier gepubliceerde synopsis steunt op die uitgave van 1968 en omvat in bijlage ook La mémoire collective chez les musiciens. De tussentitels die niet van Maurice Halbwachs zijn, werden slechts gedeeltelijk overgenomen en in sommige gevallen gewijzigd.
Émile Durkheim: de zelfdoding
Authors: Pattyn Bart
Published: May 2023

Het boek Le suicide. Étude de sociologie verscheen voor het eerst in 1897 (Paris, Félix Alcan). Deze synopsis is gebaseerd op de tweede uitgave van 1912 (Paris, Félix Alcan) en de tiende druk van de nieuwe editie van 1930 : (Quadrige, 19) Paris, PUF, 1989 (Copyright Presses Universitaires de France, Paris).
Gezinsvariabelen als verklaring voor de relatie tussen sociaal stratum en het hebben van studieproblemen bij kinderen van het eerste leerjaar
Authors: Van Eycken Monique
Published: May 2023

Het onderzoek naar de oorzaken van het verschil in onderwijsprestaties van leerlingen kan vanuit verschillende invalshoeken gebeuren. Het voorliggend onderzoek is gebaseerd op een hoofdzakelijk gezinssociologische benaderingswijze. De prestatieverschillen worden geanalyseerd via een studie van enkele gezinskarakteristieken, nl. de gezinsgrootte, de geboorterang en het taalgebruik thuis. De uiteindelijke bedoeling was na te gaan of deze variabelen enige verklaringswaarde hebben m.b.t. de relatie tussen sociaal niveau en onderwijsprestaties. Het onderzoek vond plaats bij 1.316 leerlingen van het eerste jaar basisonderwijs. De onderzoeksresultaten zijn gebaseerd op een analyse van kruistabellen en op een logistische regressie-analyse. De tendensen die naar voren komen zijn de volgende: de oudsten presteren beter dan de anderen in de geboorterang, kinderen uit kleinere gezinnen ondervinden minder leerproblemen dan deze uit grotere gezinnen en wat het taalgebruik betreft leidt een verschillend taalgebruik thuis en op school tot een toename van reeds zwakkere leergebieden. Uit de logistische regressie-analyse blijkt echter dat na controle van alle opgenomen variabelen het sociaal niveau de meest predictieve waarde heeft m.b.t. het hebben van leerstofproblemen. De gezinsstructurele factoren hebben in vergelijking hiermee weinig predictieve waarde.
Ontwikkelingen in de Belgische zorgverlening: de territorialiseringsthese
Authors: Notredame Luc
Published: May 2023

Zoals in de meeste West-Europese landen is ook de herstructurering van het Belgische zorgsysteem in een stroomversnelling gekomen. In dit: essay wordt de aandacht gericht op het: proces van vermaatschappelijking van het zorgsysteem en de daaruit voortvloeiende "onontkoombaarheid van de regulering", een opdracht die vooral door de staat ter harte wordt genomen, maar waarin management en burger een belangrijke rol spelen. Betoogd wordt dat in de (her)regulering de ruimtelijkheid een cruciale rol speelt, en deze regulering kan worden gethematiseerd als een (re)territorialisering van beleid, aanbod en vraag. Territorialiteit verschijnt hierin als een beheersingsstrategie t.a.v. de groeiende groep van mensen die aangewezen zijn op "verstatelijkte verzorgingsarrangementen".
Aandacht voor het vertoon: stijl of bricolage?
Authors: Loosveldt Geert
Published: May 2023

De initiële vraag van deze bijdrage was of er bij jongeren leefstijIpatronen te onderkennen zijn. Deze vraag werd verder uitgewerkt door na te gaan of de aandacht voor uiterlijke tekens als expressief element van de leefstijl kon beschouwd worden. Bij de onderzochte groep jongeren werden met betrekking tot die aandacht duidelijke verschillen vastgesteld. Het was mogelijk om die differentiatie te relateren aan componenten die betrekking hebben op de socio-culturele en economische dimensies van de leefstijlruimte. Daarbij dient opgemerkt dat naast deze klassieke dimensies het noodzakelijk lijkt om een ideologische dimensie in die ruimte op te nemen. Vervolgens werd, conform de definitie van het leefstijlconcept, de samenhang vastgesteld tussen de aandacht voor uiterlijke tekens en opvattingen in verband met arbeidsethos, (post)materialisme en vreemdelingen. Dit betekent dat stijlelementen kunnen beschouwd worden als een representatie van achterliggende waarden en opvattingen. Uit de resultaten blijkt dat het concept leefstijl een werk- en vruchtbaar uitgangspunt is gebleken om betekenisvolle samenhangen te detecteren en te interpreteren.