bluuebunny/crossref_metadata_2025 huggingface dataset:
Unraveling the Non‐Homogeneous Dispersion Processes in Ocean and Coastal Circulations Using a Clustering Approach
Authors: Lagomarsino‐Oneto D. , De Leo A. , Stocchino A. , Cucco A.
Published: May 2024

Dispersion processes in environmental flows have been traditionally studied under the strong assumption of homogeneous, isotropic and stationary turbulence. To overcome this limitation, we propose a new approach that combines autocorrelation analysis of simulated Lagrangian trajectories together with unsupervised clustering. To test the approach, we consider several dynamic scenarios around a coastal gulf, subject to different forcing, in order to compare our method with other approaches. Lagrangian trajectories forced by the varying coastal circulation exhibited different behaviors, looping and non‐looping paths, and produced a variety of Lagrangian autocorrelation functions. Our approach proves to be able to reveal spatio‐temporal variations in ocean dispersion processes without any a priori knowledge of the character of the trajectories. Clusters based on the autocorrelation functions are associated to different inhomogeneous dispersion processes. Finally, we propose a new stochastic model capable of predicting the different forms of autocorrelations.
Fully automatic AI segmentation of oral surgery-related tissues based on cone beam computed tomography images
Authors: Liu Yu , Xie Rui , Wang Lifeng , Liu Hongpeng , Liu Chen , Zhao Yimin , Bai Shizhu , Liu Wenyong
Published: May 2024

Accurate segmentation of oral surgery-related tissues from cone beam computed tomography (CBCT) images can significantly accelerate treatment planning and improve surgical accuracy. In this paper, we propose a fully automated tissue segmentation system for dental implant surgery. Specifically, we propose an image preprocessing method based on data distribution histograms, which can adaptively process CBCT images with different parameters. Based on this, we use the bone segmentation network to obtain the segmentation results of alveolar bone, teeth, and maxillary sinus. We use the tooth and mandibular regions as the ROI regions of tooth segmentation and mandibular nerve tube segmentation to achieve the corresponding tasks. The tooth segmentation results can obtain the order information of the dentition. The corresponding experimental results show that our method can achieve higher segmentation accuracy and efficiency compared to existing methods. Its average Dice scores on the tooth, alveolar bone, maxillary sinus, and mandibular canal segmentation tasks were 96.5%, 95.4%, 93.6%, and 94.8%, respectively. These results demonstrate that it can accelerate the development of digital dentistry.
Phenformin activates ER stress to promote autophagic cell death via NIBAN1 and DDIT4 in oral squamous cell carcinoma independent of AMPK
Authors: Zhuang Dexuan , Wang Shuangshuang , Deng Huiting , Shi Yuxin , Liu Chang , Leng Xue , Zhang Qun , Bai Fuxiang , Zheng Bin , Guo Jing , Wu Xunwei
Published: May 2024

The efficient clinical treatment of oral squamous cell carcinoma (OSCC) is still a challenge that demands the development of effective new drugs. Phenformin has been shown to produce more potent anti-tumor activities than metformin on different tumors, however, not much is known about the influence of phenformin on OSCC cells. We found that phenformin suppresses OSCC cell proliferation, and promotes OSCC cell autophagy and apoptosis to significantly inhibit OSCC cell growth both in vivo and in vitro. RNA-seq analysis revealed that autophagy pathways were the main targets of phenformin and identified two new targets DDIT4 (DNA damage inducible transcript 4) and NIBAN1 (niban apoptosis regulator 1). We found that phenformin significantly induces the expression of both DDIT4 and NIBAN1 to promote OSCC autophagy. Further, the enhanced expression of DDIT4 and NIBAN1 elicited by phenformin was not blocked by the knockdown of AMPK but was suppressed by the knockdown of transcription factor ATF4 (activation transcription factor 4), which was induced by phenformin treatment in OSCC cells. Mechanistically, these results revealed that phenformin triggers endoplasmic reticulum (ER) stress to activate PERK (protein kinase R-like ER kinase), which phosphorylates the transitional initial factor eIF2, and the increased phosphorylation of eIF2 leads to the increased translation of ATF4. In summary, we discovered that phenformin induces its new targets DDIT4 and especially NIBAN1 to promote autophagic and apoptotic cell death to suppress OSCC cell growth. Our study supports the potential clinical utility of phenformin for OSCC treatment in the future.
Strong-field photoelectron holography in the subcycle limit
Authors: Khurelbaatar Tsendsuren , Heo Jaewuk , Yu ShaoGang , Lai XuanYang , Liu XiaoJun , Kim Dong Eon
Published: May 2024

Strong-field photoelectron holography is promising for the study of electron dynamics and structure in atoms and molecules, with superior spatiotemporal resolution compared to conventional electron and X-ray diffractometry. However, the application of strong-field photoelectron holography has been hindered by inter-cycle interference from multicycle fields. Here, we address this challenge by employing a near-single-cycle field to suppress the inter-cycle interference. We observed and separated two distinct holographic patterns for the first time. Our measurements allow us not only to identify the Gouy phase effect on electron wavepackets and holographic patterns but also to correctly extract the internuclear separation of the target molecule from the holographic pattern. Our work leads to a leap jump from theory to application in the field of strong-field photoelectron holography-based ultrafast imaging of molecular structures.
A pathological joint–liver axis mediated by matrikine-activated CD4+ T cells
Authors: Yi Junzhi , Zhang Hui , Bao Fangyuan , Chen Zhichu , Zhong Yuliang , Ye Tianning , Chen Xuri , Qian Jingyi , Tian Mengya , Zhu Min , Peng Zhi , Pan Zongyou , Li Jianyou , Hu Zihao , Shen Weiliang , Xu Jiaqi , Zhang Xianzhu , Cai Youzhi , Wu Mengjie , Liu Hua , Zhou Jing , Ouyang Hongwei
Published: May 2024

The knee joint has long been considered a closed system. The pathological effects of joint diseases on distant organs have not been investigated. Herein, our clinical data showed that post-traumatic joint damage, combined with joint bleeding (hemarthrosis), exhibits a worse liver function compared with healthy control. With mouse model, hemarthrosis induces both cartilage degeneration and remote liver damage. Next, we found that hemarthrosis induces the upregulation in ratio and differentiation towards Th17 cells of CD4+ T cells in peripheral blood and spleen. Deletion of CD4+ T cells reverses hemarthrosis-induced liver damage. Degeneration of cartilage matrix induced by hemarthrosis upregulates serological type II collagen (COL II), which activates CD4+ T cells. Systemic application of a COL II antibody blocks the activation. Furthermore, bulk RNAseq and single-cell qPCR analysis revealed that the cartilage Akt pathway is inhibited by blood treatment. Intra-articular application of Akt activator blocks the cartilage degeneration and thus protects against the liver impairment in mouse and pig models. Taken together, our study revealed a pathological joint–liver axis mediated by matrikine-activated CD4+ T cells, which refreshes the organ-crosstalk axis and provides a new treatment target for hemarthrosis-related disease.
Factors involved in the remission of oral lichen planus treated with topical corticosteroids
Authors: Wongpakorn Poosit , Chantarangsu Soranun , Prapinjumrune Chanwit
Published: May 2024

Aim

To determine the factors that affected the complete clinical remission of oral lichen planus (OLP) treated with topical corticosteroids.

Material and methods

We retrospectively evaluated the charts of patients diagnosed as OLP. Age, sex, current medical conditions, medications, type of OLP, Thongprasom score, pain level assessed by a numeric rating scale (NRS),Candidainfection, topical steroid treatment preparation, duration of treatment until the first complete clinical remission, and follow-up duration were assessed as variables.

Results

In total 100 patients, after complete remission, 22 patients reported a relapse within 1.5–45 months, with a mean of 15.6 ± 13.2 months. Age, duration, gingiva and vestibule area, hypertension, dyslipidemia, Thongprasom score, preparation and topical corticosteroid potency were factors affecting the remission. Multivariate logistic regression analysis revealed that the patients’ age and duration of treatment were significant factors after adjusted for age, sex, and independent factors with aP-value < 0.1 in the univariate analysis. The likelihood of having incomplete remission of the OLP lesion increased by 7.9% for every year increase in age and increased by 2.3% for every month of treatment.

Conclusions

There are many different factors between the complete remission and incomplete remission groups. However, age and duration of treatment were significant factors affecting the remission of OLP.
RAD18 O-GlcNAcylation promotes translesion DNA synthesis and homologous recombination repair
Authors: Ma Xiaolu , Fu Hui , Sun Chenyi , Wu Wei , Hou Wenya , Zhou Zibin , Zheng Hui , Gong Yifei , Wu Honglin , Qin Junying , Lou Huiqiang , Li Jing , Tang Tie-Shan , Guo Caixia
Published: May 2024

RAD18, an important ubiquitin E3 ligase, plays a dual role in translesion DNA synthesis (TLS) and homologous recombination (HR) repair. However, whether and how the regulatory mechanism of O-linked N-acetylglucosamine (O-GlcNAc) modification governing RAD18 and its function during these processes remains unknown. Here, we report that human RAD18, can undergo O-GlcNAcylation at Ser130/Ser164/Thr468, which is important for optimal RAD18 accumulation at DNA damage sites. Mechanistically, abrogation of RAD18 O-GlcNAcylation limits CDC7-dependent RAD18 Ser434 phosphorylation, which in turn significantly reduces damage-induced PCNA monoubiquitination, impairs Polη focus formation and enhances UV sensitivity. Moreover, the ubiquitin and RAD51C binding ability of RAD18 at DNA double-strand breaks (DSBs) is O-GlcNAcylation-dependent. O-GlcNAcylated RAD18 promotes the binding of RAD51 to damaged DNA during HR and decreases CPT hypersensitivity. Our findings demonstrate a novel role of RAD18 O-GlcNAcylation in TLS and HR regulation, establishing a new rationale to improve chemotherapeutic treatment.
MeCP2 binds to methylated DNA independently of phase separation and heterochromatin organisation
Authors: Pantier Raphaël , Brown Megan , Han Sicheng , Paton Katie , Meek Stephen , Montavon Thomas , Shukeir Nicholas , McHugh Toni , Kelly David A. , Hochepied Tino , Libert Claude , Jenuwein Thomas , Burdon Tom , Bird Adrian
Published: May 2024

Correlative evidence has suggested that the methyl-CpG-binding protein MeCP2 contributes to the formation of heterochromatin condensates via liquid-liquid phase separation. This interpretation has been reinforced by the observation that heterochromatin, DNA methylation and MeCP2 co-localise within prominent foci in mouse cells. The findings presented here revise this view. MeCP2 localisation is independent of heterochromatin as MeCP2 foci persist even when heterochromatin organisation is disrupted. Additionally, MeCP2 foci fail to show hallmarks of phase separation in live cells. Importantly, we find that mouse cellular models are highly atypical as MeCP2 distribution is diffuse in most mammalian species, including humans. Notably, MeCP2 foci are absent in Mus spretus which is a mouse subspecies lacking methylated satellite DNA repeats. We conclude that MeCP2 has no intrinsic tendency to form condensates and its localisation is independent of heterochromatin. Instead, the distribution of MeCP2 in the nucleus is primarily determined by global DNA methylation patterns.
Distributed electrified heating for efficient hydrogen production
Authors: Yang Hanmin , Nuran Zaini Ilman , Pan Ruming , Jin Yanghao , Wang Yazhe , Li Lengwan , Caballero José Juan Bolívar , Shi Ziyi , Subasi Yaprak , Nurdiawati Anissa , Wang Shule , Shen Yazhou , Wang Tianxiang , Wang Yue , Sandström Linda , Jönsson Pär G. , Yang Weihong , Han Tong
Published: May 2024

This study introduces a distributed electrified heating approach that is able to innovate chemical engineering involving endothermic reactions. It enables rapid and uniform heating of gaseous reactants, facilitating efficient conversion and high product selectivity at specific equilibrium. Demonstrated in catalyst-free CH4 pyrolysis, this approach achieves stable production of H2 (530 g h−1 L reactor−1) and carbon nanotube/fibers through 100% conversion of high-throughput CH4 at 1150 °C, surpassing the results obtained from many complex metal catalysts and high-temperature technologies. Additionally, in catalytic CH4 dry reforming, the distributed electrified heating using metallic monolith with unmodified Ni/MgO catalyst washcoat showcased excellent CH4 and CO2 conversion rates, and syngas production capacity. This innovative heating approach eliminates the need for elongated reactor tubes and external furnaces, promising an energy-concentrated and ultra-compact reactor design significantly smaller than traditional industrial systems, marking a significant advance towards more sustainable and efficient chemical engineering society.
Finely manipulating room temperature phosphorescence by dynamic lanthanide coordination toward multi-level information security
Authors: Li Longqiang , Zhou Jiayin , Han Junyi , Liu Depeng , Qi Min , Xu Juanfang , Yin Guangqiang , Chen Tao
Published: May 2024

Room temperature phosphorescence materials have garnered significant attention due to their unique optical properties and promising applications. However, it remains a great challenge to finely manipulate phosphorescent properties to achieve desirable phosphorescent performance on demand. Here, we show a feasible strategy to finely manipulate organic phosphorescent performance by introducing dynamic lanthanide coordination. The organic phosphors of terpyridine phenylboronic acids possessing excellent coordination ability are covalently embedded into a polyvinyl alcohol matrix, leading to ultralong organic room temperature phosphorescence with a lifetime of up to 0.629 s. Notably, such phosphorescent performance, including intensity and lifetime, can be well controlled by varying the lanthanide dopant. Relying on the excellent modulable performance of these lanthanide-manipulated phosphorescence films, multi-level information encryption including attacker-misleading and spatial-time-resolved applications is successfully demonstrated with greatly improved security level. This work opens an avenue for finely manipulating phosphorescent properties to meet versatile uses in optical applications.
A linear response framework for quantum simulation of bosonic and fermionic correlation functions
Authors: Kökcü Efekan , Labib Heba A. , Freericks J. K. , Kemper A. F.
Published: May 2024

Response functions are a fundamental aspect of physics; they represent the link between experimental observations and the underlying quantum many-body state. However, this link is often under-appreciated, as the Lehmann formalism for obtaining response functions in linear response has no direct link to experiment. Within the context of quantum computing, and via a linear response framework, we restore this link by making the experiment an inextricable part of the quantum simulation. This method can be frequency- and momentum-selective, avoids limitations on operators that can be directly measured, and can be more efficient than competing methods. As prototypical examples of response functions, we demonstrate that both bosonic and fermionic Green’s functions can be obtained, and apply these ideas to the study of a charge-density-wave material on the ibm_auckland superconducting quantum computer. The linear response method provides a robust framework for using quantum computers to study systems in physics and chemistry.
Native N-glycome profiling of single cells and ng-level blood isolates using label-free capillary electrophoresis-mass spectrometry
Authors: Marie Anne-Lise , Gao Yunfan , Ivanov Alexander R.
Published: May 2024

The development of reliable single-cell dispensers and substantial sensitivity improvement in mass spectrometry made proteomic profiling of individual cells achievable. Yet, there are no established methods for single-cell glycome analysis due to the inability to amplify glycans and sample losses associated with sample processing and glycan labeling. In this work, we present an integrated platform coupling online in-capillary sample processing with high-sensitivity label-free capillary electrophoresis-mass spectrometry for N-glycan profiling of single mammalian cells. Direct and unbiased quantitative characterization of single-cell surface N-glycomes are demonstrated for HeLa and U87 cells, with the detection of up to 100 N-glycans per single cell. Interestingly, N-glycome alterations are unequivocally detected at the single-cell level in HeLa and U87 cells stimulated with lipopolysaccharide. The developed workflow is also applied to the profiling of ng-level amounts (5–500 ng) of blood-derived protein, extracellular vesicle, and total plasma isolates, resulting in over 170, 220, and 370 quantitated N-glycans, respectively.
Plasma proteome profiling reveals dynamic of cholesterol marker after dual blocker therapy
Authors: Lyu Jiacheng , Bai Lin , Li Yumiao , Wang Xiaofang , Xu Zeya , Ji Tao , Yang Hua , Song Zizheng , Wang Zhiyu , Shang Yanhong , Ren Lili , Li Yan , Zang Aimin , Jia Youchao , Ding Chen
Published: May 2024

Dual blocker therapy (DBT) has the enhanced antitumor benefits than the monotherapy. Yet, few effective biomarkers are developed to monitor the therapy response. Herein, we investigate the DBT longitudinal plasma proteome profiling including 113 longitudinal samples from 22 patients who received anti-PD1 and anti-CTLA4 DBT therapy. The results show the immune response and cholesterol metabolism are upregulated after the first DBT cycle. Notably, the cholesterol metabolism is activated in the disease non-progressive group (DNP) during the therapy. Correspondingly, the clinical indicator prealbumin (PA), free triiodothyronine (FT3) and triiodothyronine (T3) show significantly positive association with the cholesterol metabolism. Furthermore, by integrating proteome and radiology approach, we observe the high-density lipoprotein partial remodeling are activated in DNP group and identify a candidate biomarker APOC3 that can reflect DBT response. Above, we establish a machine learning model to predict the DBT response and the model performance is validated by an independent cohort with balanced accuracy is 0.96. Thus, the plasma proteome profiling strategy evaluates the alteration of cholesterol metabolism and identifies a panel of biomarkers in DBT.
Capture of single Ag atoms through high-temperature-induced crystal plane reconstruction
Authors: Li Jiaxin , Li Kai , Li Zhao , Wang Chunxue , Liang Yifei , Pang Yatong , Ma Jinzhu , Wang Fei , Ning Ping , He Hong
Published: May 2024

The “terminal hydroxyl group anchoring mechanism” has been studied on metal oxides (Al2O3, CeO2) as well as a variety of noble and transition metals (Ag, Pt, Pd, Cu, Ni, Fe, Mn, and Co) in a number of generalized studies, but there is still a gap in how to regulate the content of terminal hydroxyl groups to influence the dispersion of the active species and thus to achieve optimal catalytic performance. Herein, we utilized AlOOH as a precursor for γ-Al2O3 and induced the transformation of the exposed crystal face of γ-Al2O3 from (110) to (100) by controlling the calcination temperature to generate more terminal hydroxyl groups to anchor Ag species. Experimental results combined with AIMD and DFT show that temperature can drive the atomic rearrangement on the (110) crystal face, thereby forming a structure similar to the atomic arrangement of the (100) crystal face. This resulted in the formation of more terminal hydroxyl groups during the high-temperature calcination of the support (Al-900), which can capture Ag species to form single-atom dispersions, and ultimately develop a stable and efficient single-atom Ag-based catalyst.
Flash heating process for efficient meat preservation
Authors: Mao Yimin , Ma Peihua , Li Tangyuan , Liu He , Zhao Xinpeng , Liu Shufeng , Jia Xiaoxue , Rahaman Shaik O. , Wang Xizheng , Zhao Minhua , Chen Gang , Xie Hua , Brozena Alexandra H. , Zhou Bin , Luo Yaguang , Tarté Rodrigo , Wei Cheng-I , Wang Qin , Briber Robert M. , Hu Liangbing
Published: May 2024

Maintaining food safety and quality is critical for public health and food security. Conventional food preservation methods, such as pasteurization and dehydration, often change the overall organoleptic quality of the food products. Herein, we demonstrate a method that affects only a thin surface layer of the food, using beef as a model. In this method, Joule heating is generated by applying high electric power to a carbon substrate in <1 s, which causes a transient increase of the substrate temperature to > ~2000 K. The beef surface in direct contact with the heating substrate is subjected to ultra-high temperature flash heating, leading to the formation of a microbe-inactivated, dehydrated layer of ~100 µm in thickness. Aerobic mesophilic bacteria, Enterobacteriaceae, yeast and mold on the treated samples are inactivated to a level below the detection limit and remained low during room temperature storage of 5 days. Meanwhile, the product quality, including visual appearance, texture, and nutrient level of the beef, remains mostly unchanged. In contrast, microorganisms grow rapidly on the untreated control samples, along with a rapid deterioration of the meat quality. This method might serve as a promising preservation technology for securing food safety and quality.
Intramolecular autoinhibition regulates the selectivity of PRPF40A tandem WW domains for proline-rich motifs
Authors: Martínez-Lumbreras Santiago , Träger Lena K. , Mulorz Miriam M. , Payr Marco , Dikaya Varvara , Hipp Clara , König Julian , Sattler Michael
Published: May 2024

PRPF40A plays an important role in the regulation of pre-mRNA splicing by mediating protein-protein interactions in the early steps of spliceosome assembly. By binding to proteins at the 5´ and 3´ splice sites, PRPF40A promotes spliceosome assembly by bridging the recognition of the splices. The PRPF40A WW domains are expected to recognize proline-rich sequences in SF1 and SF3A1 in the early spliceosome complexes E and A, respectively. Here, we combine NMR, SAXS and ITC to determine the structure of the PRPF40A tandem WW domains in solution and characterize the binding specificity and mechanism for proline-rich motifs recognition. Our structure of the PRPF40A WW tandem in complex with a high-affinity SF1 peptide reveals contributions of both WW domains, which also enables tryptophan sandwiching by two proline residues in the ligand. Unexpectedly, a proline-rich motif in the N-terminal region of PRPF40A mediates intramolecular interactions with the WW tandem. Using NMR, ITC, mutational analysis in vitro, and immunoprecipitation experiments in cells, we show that the intramolecular interaction acts as an autoinhibitory filter for proof-reading of high-affinity proline-rich motifs in bona fide PRPF40A binding partners. We propose that similar autoinhibitory mechanisms are present in most WW tandem-containing proteins to enhance binding selectivity and regulation of WW/proline-rich peptide interaction networks.
Identification and characterization of small molecule inhibitors of the LINE-1 retrotransposon endonuclease
Authors: D’Ordine Alexandra M. , Jogl Gerwald , Sedivy John M.
Published: May 2024

The long interspersed nuclear element-1 (LINE-1 or L1) retrotransposon is the only active autonomously replicating retrotransposon in the human genome. L1 harms the cell by inserting new copies, generating DNA damage, and triggering inflammation. Therefore, L1 inhibition could be used to treat many diseases associated with these processes. Previous research has focused on inhibition of the L1 reverse transcriptase due to the prevalence of well-characterized inhibitors of related viral enzymes. Here we present the L1 endonuclease as another target for reducing L1 activity. We characterize structurally diverse small molecule endonuclease inhibitors using computational, biochemical, and biophysical methods. We also show that these inhibitors reduce L1 retrotransposition, L1-induced DNA damage, and inflammation reinforced by L1 in senescent cells. These inhibitors could be used for further pharmacological development and as tools to better understand the life cycle of this element and its impact on disease processes.
TLR agonists polarize interferon responses in conjunction with dendritic cell vaccination in malignant glioma: a randomized phase II Trial
Authors: Everson Richard G. , Hugo Willy , Sun Lu , Antonios Joseph , Lee Alexander , Ding Lizhong , Bu Melissa , Khattab Sara , Chavez Carolina , Billingslea-Yoon Emma , Salazar Andres , Ellingson Benjamin M. , Cloughesy Timothy F. , Liau Linda M. , Prins Robert M.
Published: May 2024

In this randomized phase II clinical trial, we evaluated the effectiveness of adding the TLR agonists, poly-ICLC or resiquimod, to autologous tumor lysate-pulsed dendritic cell (ATL-DC) vaccination in patients with newly-diagnosed or recurrent WHO Grade III-IV malignant gliomas. The primary endpoints were to assess the most effective combination of vaccine and adjuvant in order to enhance the immune potency, along with safety. The combination of ATL-DC vaccination and TLR agonist was safe and found to enhance systemic immune responses, as indicated by increased interferon gene expression and changes in immune cell activation. Specifically, PD-1 expression increases on CD4+ T-cells, while CD38 and CD39 expression are reduced on CD8+ T cells, alongside an increase in monocytes. Poly-ICLC treatment amplifies the induction of interferon-induced genes in monocytes and T lymphocytes. Patients that exhibit higher interferon response gene expression demonstrate prolonged survival and delayed disease progression. These findings suggest that combining ATL-DC with poly-ICLC can induce a polarized interferon response in circulating monocytes and CD8+ T cells, which may represent an important blood biomarker for immunotherapy in this patient population.Trial Registration: ClinicalTrials.gov Identifier: NCT01204684.
The differential impact of climate interventions along the political divide in 60 countries
Authors: Berkebile-Weinberg Michael , Goldwert Danielle , Doell Kimberly C. , Van Bavel Jay J. , Vlasceanu Madalina
Published: May 2024

A major barrier to climate change mitigation is the political polarization of climate change beliefs. In a global experiment conducted in 60 countries (N = 51,224), we assess the differential impact of eleven climate interventions across the ideological divide. At baseline, we find political polarization of climate change beliefs and policy support globally, with people who reported being liberal believing and supporting climate policy more than those who reported being conservative (Cohen’s d = 0.35 and 0.27, respectively). However, we find no evidence for a statistically significant difference between these groups in their engagement in a behavioral tree planting task. This conceptual-behavioral polarization incongruence results from self-identified conservatives acting despite not believing, rather than self-identified liberals not acting on their beliefs. We also find three interventions (emphasizing effective collective actions, writing a letter to a future generation member, and writing a letter from the future self) boost climate beliefs and policy support across the ideological spectrum, and one intervention (emphasizing scientific consensus) stimulates the climate action of people identifying as liberal. None of the interventions tested show evidence for a statistically significant boost in climate action for self-identified conservatives. We discuss implications for practitioners deploying targeted climate interventions.
Diamond with Sp2-Sp3 composite phase for thermometry at Millikelvin temperatures
Authors: Yin Jianan , Yan Yang , Miao Mulin , Tang Jiayin , Jiang Jiali , Liu Hui , Chen Yuhan , Chen Yinxian , Lyu Fucong , Mao Zhengyi , He Yunhu , Wan Lei , Zhou Binbin , Lu Jian
Published: May 2024

Temperature is one of the seven fundamental physical quantities. The ability to measure temperatures approaching absolute zero has driven numerous advances in low-temperature physics and quantum physics. Currently, millikelvin temperatures and below are measured through the characterization of a certain thermal state of the system as there is no traditional thermometer capable of measuring temperatures at such low levels. In this study, we develop a kind of diamond with sp2-sp3 composite phase to tackle this problem. The synthesized composite phase diamond (CPD) exhibits a negative temperature coefficient, providing an excellent fit across a broad temperature range, and reaching a temperature measurement limit of 1 mK. Additionally, the CPD demonstrates low magnetic field sensitivity and excellent thermal stability, and can be fabricated into probes down to 1 micron in diameter, making it a promising candidate for the manufacture of next-generation cryogenic temperature sensors. This development is significant for the low-temperature physics researches, and can help facilitate the transition of quantum computing, quantum simulation, and other related technologies from research to practical applications.
Multi-color dual wavelength vat photopolymerization 3D printing via spatially controlled acidity
Authors: Chin Kyle C. H. , Ovsepyan Grant , Boydston Andrew J.
Published: May 2024

Dual wavelength vat photopolymerization (DW-VP) has emerged as a powerful approach to create multimaterial objects. However, only a limited range of properties have been showcased. In this work, we report the 3D printing (3DP) of multi-color objects from a single resin vat using DW-VP. This was accomplished by concurrently curing resin with visible light and modulating local resin color with 365-nm ultraviolet (UV) light. The key advance was to use a photoacid generator (PAG) in combination with pH responsive dyes in the 3DP resins. The specific color is dictated by the extent of reaction, or local acidity in our case, and controlled by the light dosage and pattern of UV light applied. Multi-color object formation was implemented in two-step processes involving first 3DP to set the object structure, followed by UV exposure, as well as single processes that leveraged DW-VP to create a broad range of vibrant colors and patterns.
Constructing ordered and tunable extrinsic porosity in covalent organic frameworks via water-mediated soft-template strategy
Authors: He Ningning , Zou Yingdi , Chen Cheng , Tan Minghao , Zhang Yingdan , Li Xiaofeng , Jia Zhimin , Zhang Jie , Long Honghan , Peng Haiyue , Yu Kaifu , Jiang Bo , Han Ziqian , Liu Ning , Li Yang , Ma Lijian
Published: May 2024

As one of the most attractive methods for the synthesis of ordered hierarchically porous crystalline materials, the soft-template method has not appeared in covalent organic frameworks (COFs) due to the incompatibility of surfactant self-assembly and guided crystallization process of COF precursors in the organic phase. Herein, we connect the soft templates to the COF backbone through ionic bonds, avoiding their crystallization incompatibilities, thus introducing an additional ordered arrangement of soft templates into the anionic microporous COFs. The ion exchange method is used to remove the templates while maintaining the high crystallinity of COFs, resulting in the construction of COFs with ordered hierarchically micropores/mesopores, herein named OHMMCOFs (OHMMCOF-1 and OHMMCOF-2). OHMMCOFs exhibit significantly enhanced functional group accessibility and faster mass transfer rate. The extrinsic porosity can be adjusted by changing the template length, concentration, and ratio. Cationic guanidine-based COFs (OHMMCOF-3) are also constructed using the same method, which verifies the scalability of the soft-template strategy. This work provides a path for constructing ordered and tunable extrinsic porosity in COFs with greatly improved mass transfer efficiency and functional group accessibility.
From creep to flow: Granular materials under cyclic shear
Authors: Yuan Ye , Zeng Zhikun , Xing Yi , Yuan Houfei , Zhang Shuyang , Kob Walter , Wang Yujie
Published: May 2024

When unperturbed, granular materials form stable structures that resemble the ones of other amorphous solids like metallic or colloidal glasses. Whether or not granular materials under shear have an elastic response is not known, and also the influence of particle surface roughness on the yielding transition has so far remained elusive. Here we use X-ray tomography to determine the three-dimensional microscopic dynamics of two granular systems that have different roughness and that are driven by cyclic shear. Both systems, and for all shear amplitudes Γ considered, show a cross-over from creep to diffusive dynamics, indicating that rough granular materials have no elastic response and always yield, in stark contrast to simple glasses. For the system with small roughness, we observe a clear dynamic change at Γ ≈ 0.1, accompanied by a pronounced slowing down and dynamical heterogeneity. For the large roughness system, the dynamics evolves instead continuously as a function of Γ. We rationalize this roughness dependence using the potential energy landscape of the systems: The roughness induces to this landscape a micro-corrugation with a new length scale, whose ratio over the particle size is the relevant parameter. Our results reveal the unexpected richness in relaxation mechanisms for real granular materials.
Observation of interlayer plasmon polaron in graphene/WS2 heterostructures
Authors: Ulstrup Søren , in ’t Veld Yann , Miwa Jill A. , Jones Alfred J. H. , McCreary Kathleen M. , Robinson Jeremy T. , Jonker Berend T. , Singh Simranjeet , Koch Roland J. , Rotenberg Eli , Bostwick Aaron , Jozwiak Chris , Rösner Malte , Katoch Jyoti
Published: May 2024

Harnessing electronic excitations involving coherent coupling to bosonic modes is essential for the design and control of emergent phenomena in quantum materials. In situations where charge carriers induce a lattice distortion due to the electron-phonon interaction, the conducting states get “dressed", which leads to the formation of polaronic quasiparticles. The exploration of polaronic effects on low-energy excitations is in its infancy in two-dimensional materials. Here, we present the discovery of an interlayer plasmon polaron in heterostructures composed of graphene on top of single-layer WS2. By using micro-focused angle-resolved photoemission spectroscopy during in situ doping of the top graphene layer, we observe a strong quasiparticle peak accompanied by several carrier density-dependent shake-off replicas around the single-layer WS2 conduction band minimum. Our results are explained by an effective many-body model in terms of a coupling between single-layer WS2 conduction electrons and an interlayer plasmon mode. It is important to take into account the presence of such interlayer collective modes, as they have profound consequences for the electronic and optical properties of heterostructures that are routinely explored in many device architectures involving 2D transition metal dichalcogenides.
Temporal shifts in 24 notifiable infectious diseases in China before and during the COVID-19 pandemic
Authors: Li Kangguo , Rui Jia , Song Wentao , Luo Li , Zhao Yunkang , Qu Huimin , Liu Hong , Wei Hongjie , Zhang Ruixin , Abudunaibi Buasiyamu , Wang Yao , Zhou Zecheng , Xiang Tianxin , Chen Tianmu
Published: May 2024

The coronavirus disease 2019 (COVID-19) pandemic, along with the implementation of public health and social measures (PHSMs), have markedly reshaped infectious disease transmission dynamics. We analysed the impact of PHSMs on 24 notifiable infectious diseases (NIDs) in the Chinese mainland, using time series models to forecast transmission trends without PHSMs or pandemic. Our findings revealed distinct seasonal patterns in NID incidence, with respiratory diseases showing the greatest response to PHSMs, while bloodborne and sexually transmitted diseases responded more moderately. 8 NIDs were identified as susceptible to PHSMs, including hand, foot, and mouth disease, dengue fever, rubella, scarlet fever, pertussis, mumps, malaria, and Japanese encephalitis. The termination of PHSMs did not cause NIDs resurgence immediately, except for pertussis, which experienced its highest peak in December 2023 since January 2008. Our findings highlight the varied impact of PHSMs on different NIDs and the importance of sustainable, long-term strategies, like vaccine development.
Machine learning-enabled chemical space exploration of all-inorganic perovskites for photovoltaics
Authors: Kim Jin-Soo , Noh Juhwan , Im Jino
Published: May 2024

The vast compositional and configurational spaces of multi-element metal halide perovskites (MHPs) result in significant challenges when designing MHPs with promising stability and optoelectronic properties. In this paper, we propose a framework for the design of B-site-alloyed ABX3 MHPs by combining density functional theory (DFT) and machine learning (ML). We performed generalized gradient approximation with Perdew–Burke–Ernzerhof functional for solids (PBEsol) on 3,159 B-site-alloyed perovskite structures using a compositional step of 1/4. Crystal graph convolution neural networks (CGCNNs) were trained on the 3159 DFT datasets to predict the decomposition energy, bandgap, and types of bandgaps. The trained CGCNN models were used to explore the compositional and configurational spaces of 41,400 B-site-alloyed ABX3 MHPs with a compositional step of 1/16, by accessing all possible configurations for each composition. The electronic band structures of the selected compounds were calculated using the hybrid functional (PBE0). Then, we calculated the optical absorption spectra and spectroscopic limited maximum efficiency of the selected compounds. Based on the DFT/ML-combined screening, 10 promising compounds with optimal bandgaps were selected, and from among these 10 compounds, CsGe0.3125Sn0.6875I3 and CsGe0.0625Pb0.3125Sn0.625Br3 were suggested as photon absorbers for single-junction and tandem solar cells, respectively. The design framework presented herein is a good starting point for the design of mixed MHPs for optoelectronic applications.
Coexistence of superconductivity and topological phase in kagome metals ANb3Bi5 (A = K, Rb, Cs)
Authors: Si Jianguo , Shi Lanting , Chen Bozhu , Yang Huanhuan , Xu Jiyu , Liu Miao , Meng Sheng
Published: May 2024

The AV3Sb5 prototype kagome materials have been demonstrated as a versatile platform for exploring exotic properties in condensed matter physics, including charge density waves, superconductivity, non-trivial electron topology, as well as topological superconductivity. Here we identify that ANb3Bi5 (A = K, Rb, Cs) exhibit non-trivial coexisting superconductivity and topological properties via first-principles calculations. The negative formation energy and the absence of imaginary phonon dispersion demonstrate both thermodynamics and dynamics stabilities of ANb3Bi5 (A = K, Rb, Cs) under ambient conditions. By analytically solving the Allen-Dynes-modified McMillan formula, the superconducting transition temperatures are predicted to be 2.11, 2.15 and 2.21 K for KNb3Bi5, RbNb3Bi5, and CsNb3Bi5, respectively. More importantly, the kagome materials proposed here can be classified into $${{\mathbb{Z}}}_{2}$$

Z

2

topological metals due to the non-trivial topological index and the obvious surface states around the Fermi level. Such coexistence of superconductivity and non-trivial band characters in ANb3Bi5 (A = K, Rb, Cs) offer us more insights to study the relationship between superconductivity and topological properties, and to design innate topological superconductors.
Transcriptomic imputation of genetic risk variants uncovers novel whole-blood biomarkers of Parkinson’s disease
Authors: Chew Gabriel , Mai Aaron Shengting , Ouyang John F. , Qi Yueyue , Chao Yinxia , Wang Qing , Petretto Enrico , Tan Eng-King
Published: May 2024

Blood-based gene expression signatures could potentially be used as biomarkers for PD. However, it is unclear whether genetically-regulated transcriptomic signatures can provide novel gene candidates for use as PD biomarkers. We leveraged on the Genotype-Tissue Expression (GTEx) database to impute whole-blood transcriptomic expression using summary statistics of three large-scale PD GWAS. A random forest classifier was used with the consensus whole-blood imputed gene signature (IGS) to discriminate between cases and controls. Outcome measures included Area under the Curve (AUC) of Receiver Operating Characteristic (ROC) Curve. We demonstrated that the IGS (n = 37 genes) is conserved across PD GWAS studies and brain tissues. IGS discriminated between cases and controls in an independent whole-blood RNA-sequencing study (1176 PD, 254 prodromal, and 860 healthy controls) with mean AUC and accuracy of 64.8% and 69.4% for PD cohort, and 78.8% and 74% for prodromal cohort. PATL2 was the top-performing imputed gene in both PD and prodromal PD cohorts, whose classifier performance varied with biological sex (higher performance for males and females in the PD and prodromal PD, respectively). Single-cell RNA-sequencing studies (scRNA-seq) of healthy humans and PD patients found PATL2 to be enriched in terminal effector CD8+ and cytotoxic CD4+ cells, whose proportions are both increased in PD patients. We demonstrated the utility of GWAS transcriptomic imputation in identifying novel whole-blood transcriptomic signatures which could be leveraged upon for PD biomarker derivation. We identified PATL2 as a potential biomarker in both clinical and prodromic PD.
A global time series of traffic volumes on extra-urban roads
Authors: van Strien Maarten J. , Grêt-Regamey Adrienne
Published: May 2024

Traffic on roads outside of urban areas (i.e. extra-urban roads) can have major ecological and environmental impacts on agricultural, forested, and natural areas. Yet, data on extra-urban traffic volumes is lacking in many regions. To address this data gap, we produced a global time-series of traffic volumes (Annual Average Daily Traffic; AADT) on all extra-urban highways, primary roads, and secondary roads for the years 1975, 1990, 2000 and 2015. We constructed time series of road networks from existing global datasets on roads, population density, and socio-economic indicators, and combined these with a large collection of empirical AADT data from all continents except Antarctica. We used quantile regression forests to predict the median and 5% and 95% prediction intervals of AADT on each road section. The validation accuracy of the model was high (pseudo-R2 = 0.7407) and AADT predictions from 1975 were also accurate. The resulting map series provides standardised and fine-scaled information on the development of extra-urban road traffic and has a wide variety of practical and scientific applications.
Comprehensive energy demand and usage data for building automation
Authors: Heer Philipp , Derungs Curdin , Huber Benjamin , Bünning Felix , Fricker Reto , Stoller Sascha , Niesen Björn
Published: May 2024

Buildings are essential in satisfying our daily need for comfort (privacy, protection from weather, etc.) and are responsible for almost half of the world’s total energy consumption. Research at the interface of room comfort and energy efficiency is of critical societal importance. At the same time, there is a lack of publicly available data to optimize important building functions automatically. It is only through data-driven approaches that building automation becomes financially affordable and achieves widespread adoption. In this publication, measurement data from three buildings of the NEST platform are made publicly available. The dataset includes detailed information on energy consumption (electricity, heating, cooling, domestic hot water), building operation (set points, valve openings, windows), and occupant practice (e.g., presence, operation of blinds and kitchen, showering patterns). All data have been measured over four years and with a temporal resolution of 1 minute. This combination of information allows learning the function of different building types (office and residential) and thus addresses important research gaps.
Association of the CUN-BAE body adiposity estimator and other obesity indicators with cardiometabolic multimorbidity: a cross-sectional study
Authors: Chen Xuejiao , Geng Shuoji , Shi Zhan , Ding Jiacheng , Li Haojie , Su Donghai , Cheng Yulin , Shi Songhe , Tian Qingfeng
Published: May 2024

Cardiometabolic multimorbidity (CM), defined as the coexistence of two or three cardiometabolic disorders, is one of the most common and deleterious multimorbidities. This study aimed to investigate the association of Clínica Universidad de Navarra-Body Adiposity Estimator (CUN-BAE), body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR) with the prevalence of CM. The data were obtained from the 2021 health checkup database for residents of the Electronic Health Management Center in Xinzheng, Henan Province, China. 81,532 participants aged ≥ 60 years were included in this study. Logistic regression models were used to estimate the odd ratios (ORs) and 95% confidence intervals (CIs) for CUN-BAE, BMI, WC, and WHtR in CM. The area under the receiver operating characteristic curve (AUC) was used to compare the discriminatory ability of different anthropometric indicators for CM. The multivariable-adjusted ORs (95% CIs) (per 1 SD increase) of CM were 1.799 (1.710–1.893) for CUN-BAE, 1.329 (1.295–1.364) for BMI, 1.343 (1.308–1.378) for WC, and 1.314 (1.280–1.349) for WHtR, respectively. Compared with BMI, WC and WHtR, CUN-BAE had the highest AUC in both males and females (AUC: 0.642; 95% CI 0.630–0.653 for males, AUC: 0.614; 95% CI 0.630–0.653 for females). CUN-BAE may be a better measure of the adverse effect of adiposity on the prevalence of CM than BMI, WC, and WHtR.
CSChighE-cadherinlow immunohistochemistry panel predicts poor prognosis in oral squamous cell carcinoma
Authors: Ortiz Rafael Carneiro , Amôr Nádia Ghinelli , Saito Luciana Mieli , Santesso Mariana Rodrigues , Lopes Nathália Martins , Buzo Rodrigo Fonseca , Fonseca Angélica Cristina , Amaral-Silva Gleyson Kleber , Moyses Raquel Ajub , Rodini Camila Oliveira
Published: May 2024

Identifying marker combinations for robust prognostic validation in primary tumour compartments remains challenging. We aimed to assess the prognostic significance of CSC markers (ALDH1, CD44, p75NTR, BMI-1) and E-cadherin biomarkers in OSCC. We analysed 94 primary OSCC and 67 metastatic lymph node samples, including central and invasive tumour fronts (ITF), along with clinicopathological data. We observed an increase in ALDH1+/CD44+/BMI-1- tumour cells in metastatic lesions compared to primary tumours. Multivariate analysis highlighted that elevated p75NTR levels (at ITF) and reduced E-cadherin expression (at the tumour centre) independently predicted metastasis, whilst ALDH1high exhibited independent predictive lower survival at the ITF, surpassing the efficacy of traditional tumour staging. Then, specifically at the ITF, profiles characterized by CSChighE-cadherinlow (ALDH1highp75NTRhighE-cadherinlow) and CSCintermediateE-cadherinlow (ALDH1 or p75NTRhighE-cadherinlow) were significantly associated with worsened overall survival and increased likelihood of metastasis in OSCC patients. In summary, our study revealed diverse tumour cell profiles in OSCC tissues, with varying CSC and E-cadherin marker patterns across primary tumours and metastatic sites. Given the pivotal role of reduced survival rates as an indicator of unfavourable prognosis, the immunohistochemistry profile identified as CSChighE-cadherinlow at the ITF of primary tumours, emerges as a preferred prognostic marker closely linked to adverse outcomes in OSCC.