bluuebunny/crossref_metadata_2025 huggingface dataset:
Retrieval of monthly average hourly values of direct and diffuse solar irradiance from measurements of global radiation in Spain
Authors: Pérez-Burgos A. , Díez-Mediavilla M. , Alonso-Tristán C. , Dieste-Velasco M. I.
Published: April 2018

An exhaustive evaluation of the performance of decomposition models to estimate direct and diffuse components from the global horizontal solar irradiance has been carried out in this work. The main objective of this work has been to compare the model performance for two different time bases, hourly and monthly average hourly bases. An extensive database of horizontal solar irradiance from nine locations in Spain was used for the study. The data span through January 1980 to December 2012 of hourly solar irradiance for the nine locations and thus indicate a cumulative year sum of 132 years. This study first investigated the decomposition of the hourly horizontal irradiance into hourly direct and diffuse components using six decomposition models widely referenced in the bibliography. In the hourly decomposition investigation, it was observed that there are no significant differences between the six models for each specific location. Nevertheless, the performance of each of the models was strongly dependent on cloudiness conditions and the solar altitude at the location which is associated with the climatic condition of each site. Further investigations using the six decomposition models were conducted to estimate monthly average hourly values of direct and diffuse components of the solar irradiance with proper assessment of the different models' performance at various locations. Based on the results of the investigations which present no significant differences in the performance of the different models, an extremely simple algorithm was developed to estimate monthly average hourly values of direct and diffuse solar irradiance, which reduces the statistical errors in all locations investigated.
Characterization of free-standing InAs quantum membranes by standing wave hard x-ray photoemission spectroscopy
Authors: Conti G. , Nemšák S. , Kuo C.-T. , Gehlmann M. , Conlon C. , Keqi A. , Rattanachata A. , Karslıoğlu O. , Mueller J. , Sethian J. , Bluhm H. , Rault J. E. , Rueff J. P. , Fang H. , Javey A. , Fadley C. S.
Published: April 2018

Free-standing nanoribbons of InAs quantum membranes (QMs) transferred onto a (Si/Mo) multilayer mirror substrate are characterized by hard x-ray photoemission spectroscopy (HXPS) and by standing-wave HXPS (SW-HXPS). Information on the chemical composition and on the chemical states of the elements within the nanoribbons was obtained by HXPS and on the quantitative depth profiles by SW-HXPS. By comparing the experimental SW-HXPS rocking curves to x-ray optical calculations, the chemical depth profile of the InAs(QM) and its interfaces were quantitatively derived with ångström precision. We determined that (i) the exposure to air induced the formation of an InAsO4 layer on top of the stoichiometric InAs(QM); (ii) the top interface between the air-side InAsO4 and the InAs(QM) is not sharp, indicating that interdiffusion occurs between these two layers; (iii) the bottom interface between the InAs(QM) and the native oxide SiO2 on top of the (Si/Mo) substrate is abrupt. In addition, the valence band offset (VBO) between the InAs(QM) and the SiO2/(Si/Mo) substrate was determined by HXPS. The value of VBO = 0.2 ± 0.04 eV is in good agreement with literature results obtained by electrical characterization, giving a clear indication of the formation of a well-defined and abrupt InAs/SiO2 heterojunction. We have demonstrated that HXPS and SW-HXPS are non-destructive, powerful methods for characterizing interfaces and for providing chemical depth profiles of nanostructures, quantum membranes, and 2D layered materials.
Electroluminescence and electrical degradation of insulating polymers at electrode interfaces under divergent fields
Authors: Zhang Shuai , Li Qi , Hu Jun , Zhang Bo , He Jinliang
Published: April 2018

Electrical degradation of insulating polymers at electrode interfaces is an essential factor in determining long-term reliability. A critical challenge is that the exact mechanism of degradation is not fully understood, either experimentally or theoretically, due to the inherent complex processes. Consequently, in this study, we investigate electroluminescence (EL) at the interface of an electrode and insulator, and determine the relationship between EL and electrical degradation. Using a tip-plate electrode structure, the unique features of EL under a highly divergent field are investigated. The voltage type (alternating or direct current), the polymer matrix, and the time of pressing are also investigated separately. A study of EL from insulators under a divergent field is provided, and the relationship between EL spectra and degradation is discussed. It is shown that EL spectra under a divergent field have unique characteristics compared with EL spectra from polymer films under a uniform field and the most obvious one is the UV emission. The results obtained in the current investigation bring us a step closer to understanding the process of electrical degradation and provide a potential way to diagnose insulator defects.
Corrigendum to: Supporting return to work through appropriate certification: a systematic approach for Australian primary care
Authors: Papagoras Harry , Pizzari Tania , Coburn Paul , Sleigh Kevin , Briggs Andrew M.
Published: April 2018

Primary care practitioners play a critical role in supporting return to work (RTW) and minimising the detrimental physical and psychosocial sequelae of unnecessary and prolonged work absence in injured and ill workers. Accurate and consistent certification of capacity is an essential component of this role that has been scrutinised recently given the identified variation in certification practices between and within professions. This Perspective outlines the importance of correct certification of capacity for injured workers and provides a RTW flowchart to support systematised and appropriate certification. The flowchart is aimed at primary care practitioners (e.g. general practitioners or physiotherapists). The flowchart was developed at the Transport Accident Commission and WorkSafe Victoria as a guide for Australian primary care practitioners when certifying capacity. A more systematised approach to certification coupled with professional education and support may reduce variations and inaccuracies in certification, improve RTW rates and reduce the increasing burden of disease related to workplace injuries.
The Asia-Pacific origins of the current outbreaks of Zika virus
Authors: Sam Jamal I-Ching
Published: April 2018

Zika virus (ZIKV) is a mosquito-borne arbovirus from the Flaviviridae family, first isolated in 1947 from a monkey in Uganda. In the ensuing decades up to the 2000s, there have been sporadic reports of infections and seropositivity in humans in Africa and Asia1,2. The first isolation of ZIKV outside Africa was from Aedes aegypti mosquitoes in Malaysia in 19663. Seropositivity has also been reported in wild monkeys in Malaysia3, although the relevance of this in sylvatic transmission of ZIKV is unknown. These studies suggest that there was endemic and mostly undetected transmission in Asia during this period. Re-emergence from Asia has now brought this relatively neglected virus into the focus of global attention.
Neurological disease caused by flavivirus infections
Authors: Gibbs Tristan , Speers David J
Published: April 2018

The Flavivirus genus contains dozens of species with varying geographical distributions. Most flavivirus infections in humans are asymptomatic or manifest as a non-specific febrile illness, sometimes accompanied by rash or arthralgia. Certain species are more commonly associated with neurological disease and may be termed neurotropic flaviviruses. Several flaviviruses endemic to Australia and our near northern neighbours are neurotropic, such as Murray Valley encephalitis virus, West Nile (Kunjin) virus and Japanese encephalitis virus. Flavivirus neurological disease ranges from self-limiting meningitis to fulminant encephalitis causing permanent debilitating neurological sequelae or death. The recent Zika virus outbreak in South America has highlighted the dramatic effects of flavivirus neurotropism on the developing brain. This article focuses on the neurotropic flaviviruses endemic to Australia and those of international significance.
Shortwave infrared fluorescence imaging with the clinically approved near-infrared dye indocyanine green
Authors: Carr Jessica A. , Franke Daniel , Caram Justin R. , Perkinson Collin F. , Saif Mari , Askoxylakis Vasileios , Datta Meenal , Fukumura Dai , Jain Rakesh K. , Bawendi Moungi G. , Bruns Oliver T.
Published: April 2018

Significance

Imaging in the shortwave IR (SWIR) spectral window allows the observation of processes deep within living animals. Recent studies have shown that SWIR imaging enables unprecedented imaging opportunities, including contact-free monitoring of vital signs, generation of microvasculature blood flow maps, real-time metabolic imaging, and molecularly targeted imaging. Yet, whereas bright SWIR fluorophores have been developed for preclinical research settings, applications in the clinic have been held back by the conventional belief that no clinically approved fluorophore is available. Here, we show that indocyanine green, a clinically approved near-IR dye, exhibits a remarkable amount of SWIR emission, which enables state-of-the-art SWIR imaging with direct translation potential into clinical settings, and even outperforms other commercially available SWIR emitters.
Light-activated helical inversion in cholesteric liquid crystal microdroplets
Authors: Sleczkowski Piotr , Zhou Ye , Iamsaard Supitchaya , de Pablo Juan J. , Katsonis Nathalie , Lacaze Emmanuelle
Published: April 2018

Significance

Controlled switching between right- and left-handedness in spherical cholesteric droplets could lead to easily manufacturable objects for diverse applications in optoelectronics, especially in the area of circularly polarized light-responsive materials and devices. In this work, we show that photoinduced inversion of the cholesteric helix is supported in spherical droplets of a nematic liquid crystal doped with a chiral light-driven molecular motor. We show how the handedness inversion occurs in the sequence of phase transitions induced by light irradiation, combining experiments on several hundreds of droplets and simulations. We demonstrate the strong influence of the confinement on the droplet structure and on the dynamics under light irradiation, which allows for this handedness inversion.
Aquaculture pond fertilization.
Authors: Boyd C. E.
Published: April 2018

Organic fertilizers (livestock manures and other agricultural wastes or by-products) and chemical fertilizers can be applied to aquaculture ponds to increase fish or shrimp production. Pond fertilization increases concentrations of nitrogen, phosphorus and other plant nutrients to stimulate phytoplankton photosynthesis that is the base of the food web culminating in shrimp and fish production. Fertilization usually results in two to fivefold increase in aquaculture production. Organic fertilizers tend to increase production above that possible with chemical fertilizers, but a combination of organic and chemical fertilization usually results in greater production than does either type of fertilization alone. Manufactured feeds allow much greater production than possible with fertilizers, and feeding has become more common than pond fertilization. However, fertilization remains an important practice for smallholder farmers in developing countries. It also is sometimes applied early in the grow-out period in feed-based aquaculture, and it is a common technique for increasing production of sportfish ponds.
Quality improvement by batch vacuum distillation and physicochemical characterization of clove leaf oil in Central Java, Indonesia
Authors: Alighiri D , Eden W T , Cahyono E , Supardi K I
Published: April 2018

Clove leaf oil is one of the essential oils which have high economic value and produced in considerable amount in Indonesia. As many as 60% of clove oil produced by Indonesia has exported to many countries in the world. Musuk and Ringinlarik Village, Boyolali District, Central Java Province is one of the areas in Indonesia which became the primary supplier of Indonesian clove leaf oil. Although, the quality of the resulting yield is still low because it uses a simple distillation kettle in the form of the iron plate or used the drum. The clove leaf oil produced by steam distillation from the dry whole leaves of the clove tree. The color of the oil is brownish black and dirty with the odor are fresh distilled, spicy, warm, and terpenic. The specific gravity at 25 °C of 1.529, the refractive index at 20 °C of 1.030, and based on GC-MS analysis, eugenol levels only 68% and caryophyllene is too high, i.e., 20%. The quality of clove leaf oil produced does not meet the specifications of international market standards. This work aimed to improve the quality of Indonesian clove leaf oil. The purifications done in this research was used by batch vacuum distillation with mode operation at vacuum -76 cmHg and reflux ratios 5:1. Clove leaf oil produced by using this method has a better physicochemical characterization, i.e., the appearance that is yellow to pale color with the odor is spicy, woody, warm, and terpenic. The specific gravity at 25 °C of 1.533, the refractive index at 20 °C of 1.038, and eugenol and caryophyllene contents has yielded 80.58% and 10%, respectively. By The enhancement quality of clove leaf oil by batch vacuum distillation, these oil is already meet international standards and income of clove leaf oil grower in Musuk and Ringinlarik Village, Boyolali District, Central Java Province, Indonesia could be increased.
The selection of flying roller as an effort to increase the power of scooter-matic as the main power of centrifugal pump for fire fighter motor cycle
Authors: Sutrisno Himawan Hadi
Published: April 2018

In densely populated settlements, fires often occur and cause losses. In some instances, the process of the occurrence of fires takes place so quickly that to reduce and avoid the occurrence of a fire disaster effort is required in accordance with the existing environmental condition. Fire fighter motorcycle by using motorcycle scooter-matic is considered suitable as one alternative to combating fire hazard in densely populated residential settlements. The use of motorcycle engines as the driving force of the pump often leads to unstable and not optimum power. Thus, the water spray on the centrifugal pump also becomes not maximum. To increase the engine power at scooter-matic engine idle rotation (700-2000 rpm), then the flying roller replacement with certain mass weight becomes an option. By selecting a 10 to 14 gram flying roller mass, the power analysis using a dynotest engine produces several variations. Of the calculation, the mass of a 14 gram flying roller provides a significant increase in motor power on the upper rotation. Meanwhile, on the lower power rotation using a flying roller with a mass of 10 grams provides an increase in power compared to a standard flying roller on a scooter matic motor engine. As a reference to the use of scooter-matic motor power as the pump power, the result of use of the flying roller with a mass of 10 grams becomes the best option.
Application of Response Surface Methodology for characterization of ozone production from Multi-Cylinder Reactor in non-thermal plasma device
Authors: See Tan Lian , Shah Zulkifli Ahmad Zulazlan , Tzeng Lim Mook
Published: April 2018

Ozone is a reactant which can be applied for various environmental treatment processes. It can be generated via atmospheric air non-thermal plasmas when sufficient voltages are applied through a combination of electrodes and dielectric materials. In this study, the concentration of ozone generated via two different configurations of multi-cylinder dielectric barrier discharge (DBD) reactor (3 x 40 mm and 10 x 10 mm) was investigated. The influence of the voltage and the duty cycle to the concentration of ozone generated by each configuration was analysed using response surface methodology. Voltage was identified as significant factor to the ozone production process. However, the regressed model was biased towards one of the configuration, leaving the predicted results of another configuration to be out of range.
The Income Volatility of U.S. Commercial Farm Households
Authors: Key Nigel , Prager Daniel L , Burns Christopher B
Published: April 2018

This study uses a newly created panel dataset drawn from the 1997 to 2013 Agricultural Resource Management Survey to provide the first national estimates of income volatility for commercial farm households in the United States. Results show that the income of commercial farm households is substantially more volatile than that of all U.S. households—though the volatility of farm income is not more volatile than income from nonfarm self‐employment. Using a regression analysis, we identify operator, operation, and regional characteristics associated with higher income volatility, providing information that could improve targeting of risk‐mitigating programs. We find that farm income volatility has declined for farms specializing in program crops in recent decades, supporting the hypothesis that the expansion of the federal crop insurance program helped reduce farm income risk.
Staging an Empire: An Ottoman Circumcision Ceremony as Cultural Performance
Authors: Şahin Kaya
Published: April 2018

This article discusses an Ottoman circumcision ceremony for three princes held in the summer of 1530. The event stemmed from a new Ottoman court ceremonial, and its sundry activities, including gift exchanges, mock battles, processions, skills demonstrations, and feasts, were spread over a twenty-day period. These activities enabled individuals and groups within the Ottoman political-military elite, and within the city of Constantinople, to perform their identities and assert their place in the Ottoman social order. The ceremony allows us to discuss the origins and contents of Ottoman ceremonial culture, which borrowed themes and motifs from the Byzantines, the Venetians, and the myriad Turko-Muslim polities with whom the Ottomans maintained intense diplomatic and cultural relations. Next, it highlights the elevation of male circumcision, a fundamental ritual in all Islamic societies, to the status of a major dynastic event that addressed the entire Ottoman polity as well as its competitors in East and West. Finally, it shows how, in early modern societies, public ceremonies served as instruments of governance by creating highly visible, memorable, and relatively participatory events, and by constituting new spaces for political and cultural interactions.
VSClust: feature-based variance-sensitive clustering of omics data
Authors: Schwämmle Veit , Jensen Ole N
Published: April 2018

Motivation

Data clustering is indispensable for identifying biologically relevant molecular features in large-scale omics experiments with thousands of measurements at multiple conditions. Optimal clustering results yield groups of functionally related features that may include genes, proteins and metabolites in biological processes and molecular networks. Omics experiments typically include replicated measurements of each feature within a given condition to statistically assess feature-specific variation. Current clustering approaches ignore this variation by averaging, which often leads to incorrect cluster assignments.

Results

We present VSClust that accounts for feature-specific variance. Based on an algorithm derived from fuzzy clustering, VSClust unifies statistical testing with pattern recognition to cluster the data into feature groups that more accurately reflect the underlying molecular and functional behavior. We apply VSClust to artificial and experimental datasets comprising hundreds to >80 000 features across 6–20 different conditions including genomics, transcriptomics, proteomics and metabolomics experiments. VSClust avoids arbitrary averaging methods, outperforms standard fuzzy c-means clustering and simplifies the data analysis workflow in large-scale omics studies.

Availability and implementation

Download VSClust at https://bitbucket.org/veitveit/vsclust or access it through computproteomics.bmb.sdu.dk/Apps/VSClust.

Supplementary information

Supplementary data are available at Bioinformatics online.
Health Effects of the Relocation of Patients With Dementia: A Scoping Review to Inform Medical and Policy Decision-Making
Authors: Ryman Frida V M , Erisman Jetske C , Darvey Lea M , Osborne Jacob , Swartsenburg Ella , Syurina Elena V
Published: April 2018

Background and Objectives

Research into the relocation (including international relocation) of people with dementia is increasingly important due to the aging population and latest developments in the international politics (including globalization and concerns over international migration). There is need for an overview of the health effects of relocation to facilitate and inform decision- and policy-making regarding these relocations. The aim of this literature review was to provide insight into the physical, psychological, and social consequences of varied types of relocations of older adults suffering from dementia.

Research Design and Methods

A scoping literature review with a systematic search was performed in PubMed, Web of Science, PsychInfo, JSTOR, and ScienceDirect. The articles dealing with subject of relocation of older adults from 1994 to 2017 were included and analyzed. Methodological quality assessment was performed for all articles.

Results

Final list included 13 articles. The effects of relocation were discussed in terms of mortality and morbidity. In most studies, the health effects of the relocation of older adults suffering from dementia were negative. A decline in physical, mental, behavioral, and functional well-being was reported. The most recurring effect was a higher level of stress, which is more problematic for patients with dementia. In general, unless it is carefully planned, it is best to avoid changing lives of people with dementia and it is recommended to actively work to reduce their exposure to stress.

Discussion and Implications

The outcomes of the study suggest definite evidence for the negative effects of relocation of the older adults. This research aims to be used as the support of the legal and medical decisions of relocation of patients with dementia.
Patient information organization in the intensive care setting: expert knowledge elicitation with card sorting methods
Authors: Reese Thomas , Segall Noa , Nesbitt Paige , Del Fiol Guilherme , Waller Rosalie , Macpherson Brekk C , Tonna Joseph E , Wright Melanie C
Published: April 2018

Introduction

Many electronic health records fail to support information uptake because they impose low-level information organization tasks on users. Clinical concept-oriented views have shown information processing improvements, but the specifics of this organization for critical care are unclear.

Objective

To determine high-level cognitive processes and patient information organization schema in critical care.

Methods

We conducted an open card sort of 29 patient data elements and a modified Delphi card sort of 65 patient data elements. Study participants were 39 clinicians with varied critical care training and experience. We analyzed the open sort with a hierarchical cluster analysis (HCA) and factor analysis (FA). The Delphi sort was split into three initiating groups that resulted in three unique solutions. We compared results between open sort analyses (HCA and FA), between card sorting exercises (open and Delphi), and across the Delphi solutions.

Results

Between the HCA and FA, we observed common constructs including cardiovascular and hemodynamics, infectious disease, medications, neurology, patient overview, respiratory, and vital signs. The more comprehensive Delphi sort solutions also included gastrointestinal, renal, and imaging constructs.

Conclusions

We identified primarily system-based groupings (e.g., cardiovascular, respiratory). Source-based (e.g., medications, laboratory) groups became apparent when participants were asked to sort a longer list of concepts. These results suggest a hybrid approach to information organization, which may combine systems, source, or problem-based groupings, best supports clinicians’ mental models. These results can contribute to the design of information displays to better support clinicians’ access and interpretation of information for critical care decisions.
The Bursting Pulsar GRO J1744−28: the slowest transitional pulsar?
Authors: Court J M C , Altamirano D , Sanna A
Published: April 2018

GRO J1744−28 (the Bursting Pulsar) is a neutron star low-mass X-ray binary which shows highly structured X-ray variability near the end of its X-ray outbursts. In this letter we show that this variability is analogous to that seen in Transitional Millisecond Pulsars such as PSR J1023+0038: ‘missing link’ systems consisting of a pulsar nearing the end of its recycling phase. As such, we show that the Bursting Pulsar may also be associated with this class of objects. We discuss the implications of this scenario; in particular, we discuss the fact that the Bursting Pulsar has a significantly higher spin period and magnetic field than any other known transitional pulsar. If the Bursting Pulsar is indeed transitional, then this source opens a new window of opportunity to test our understanding of these systems in an entirely unexplored physical regime.
An interstellar origin for Jupiter’s retrograde co-orbital asteroid
Authors: Namouni F , Morais M H M
Published: April 2018

Asteroid (514107) 2015 BZ509 was discovered recently in Jupiter’s co-orbital region with a retrograde motion around the Sun. The known chaotic dynamics of the outer Solar system have so far precluded the identification of its origin. Here, we perform a high-resolution statistical search for stable orbits and show that asteroid (514107) 2015 BZ509 has been in its current orbital state since the formation of the Solar system. This result indicates that (514107) 2015 BZ509 was captured from the interstellar medium 4.5 billion years in the past as planet formation models cannot produce such a primordial large-inclination orbit with the planets on nearly coplanar orbits interacting with a coplanar debris disc that must produce the low-inclination small-body reservoirs of the Solar system such as the asteroid and Kuiper belts. This result also implies that more extrasolar asteroids are currently present in the Solar system on nearly polar orbits.
Recovering the systemic redshift of galaxies from their Lyman alpha line profile
Authors: Verhamme A , Garel T , Ventou E , Contini T , Bouché N , Herenz EC , Richard J , Bacon R , Schmidt KB , Maseda M , Marino RA , Brinchmann J , Cantalupo S , Caruana J , Clément B , Diener C , Drake AB , Hashimoto T , Inami H , Kerutt J , Kollatschny W , Leclercq F , Patrício V , Schaye J , Wisotzki L , Zabl J
Published: April 2018

The Lyman alpha (Ly α) line of Hydrogen is a prominent feature in the spectra of star-forming galaxies, usually redshifted by a few hundreds of km s−1 compared to the systemic redshift. This large offset hampers follow-up surveys, galaxy pair statistics, and correlations with quasar absorption lines when only Ly α is available. We propose diagnostics that can be used to recover the systemic redshift directly from the properties of the Ly α line profile. We use spectroscopic observations of Ly α emitters for which a precise measurement of the systemic redshift is available. Our sample contains 13 sources detected between z ≈ 3 and z ≈ 6 as part of various multi-unit spectroscopic explorer guaranteed time observations. We also include a compilation of spectroscopic Ly α data from the literature spanning a wide redshift range (z ≈ 0–8). First, restricting our analysis to double-peaked Ly α spectra, we find a tight correlation between the velocity offset of the red peak with respect to the systemic redshift, $V_{\rm peak}^{\rm red}$, and the separation of the peaks. Secondly, we find a correlation between $V_{\rm peak}^{\rm red}$ and the full width at half-maximum of the Ly α line. Fitting formulas to estimate systemic redshifts of galaxies with an accuracy of ≤100 km s−1, when only the Ly α emission line is available, are given for the two methods.
Microsurgery Versus Stereotactic Radiosurgery for Brain Arteriovenous Malformations: A Matched Cohort Study
Authors: Chen Ching-Jen , Ding Dale , Wang Tony R , Buell Thomas J , Ilyas Adeel , Ironside Natasha , Lee Cheng-Chia , Kalani M Yashar , Park Min S , Liu Kenneth C , Sheehan Jason P
Published: April 2018

BACKGROUND

Microsurgery (MS) and stereotactic radiosurgery (SRS) remain the preferred interventions for the curative treatment of brain arteriovenous malformations (AVM), but their relative efficacy remains incompletely defined.

OBJECTIVE

To compare the outcomes of MS to SRS for AVMs through a retrospective, matched cohort study.

METHODS

We evaluated institutional databases of AVM patients who underwent MS and SRS. MS-treated patients were matched, in a 1:1 ratio based on patient and AVM characteristics, to SRS-treated patients. Statistical analyses were performed to compare outcomes data between the 2 cohorts. The primary outcome was defined as AVM obliteration without a new permanent neurological deficit.

RESULTS

The matched MS and SRS cohorts were each comprised of 59 patients. Both radiological (85 vs 11 mo; P < .001) and clinical (92 vs 12 mo; P < .001) follow-up were significantly longer for the SRS cohort. The primary outcome was achieved in 69% of each cohort. The MS cohort had a significantly higher obliteration rate (98% vs 72%; P = .001), but also had a significantly higher rate of new permanent deficit (31% vs 10%; P = .011). The posttreatment hemorrhage rate was significantly higher for the SRS cohort (10% for SRS vs 0% for MS; P = .027). In subgroup analyses of ruptured and unruptured AVMs, no significant differences between the primary outcomes were observed.

CONCLUSION

For patients with comparable AVMs, MS and SRS afford similar rates of deficit-free obliteration. Nidal obliteration is more frequently achieved with MS, but this intervention also incurs a greater risk of new permanent neurological deficit.
Framework Convention on Tobacco Control Implementation in Nigeria: Lessons for Low- and Middle-Income Countries
Authors: Egbe Catherine O , Bialous Stella A , Glantz Stanton
Published: April 2018

Background

Nigeria is a significant tobacco market and influential country in Africa. Nigeria ratified the WHO Framework Convention on Tobacco Control (FCTC) in 2005. We reviewed Nigeria’s tobacco control legislation since 2000 and compliance of the National Tobacco Control Act (NTCA) 2015 with the FCTC.

Methods

We reviewed the National Tobacco Control Bills 2011 (proposed by legislature) and 2014 (proposed by Executive), the NTCA 2015, and media stories on tobacco control from 2008 to 2017.

Results

The NTCA, despite being more comprehensive than Nigeria’s first Tobacco Smoking (Control) law of 1990, maintained provisions promoted by the tobacco industry, for example: allowing designated smoking areas in hospitality venues, higher educational institutions, and transportation venues; a loophole in the advertising restrictions allowing communications with consenting adults; and having the Manufacturers Association of Nigeria (MAN) (which includes tobacco companies) on the National Tobacco Control Committee charged with working with the Ministry of Health to implement the law. The industry is also directly involved with the Standards Organisation of Nigeria (SON) in preparing regulations on cigarette constituents and emissions. In an unprecedented step globally, the law requires that implementing regulations be approved by the National Assembly, giving the industry another opportunity to weaken this law further by lobbying the legislators to favor the industry. As of January 2018, the law was still not being enforced.

Conclusion

The NTCA can be strengthened through implementation guidelines still being developed. The industry should be prevented from interfering with through MAN and SON, as required by FCTC Article 5.3.

Implications

The tobacco industry works to block Framework Convention on Tobacco Control implementation even after a country ratifies the treaty. The Nigerian case illustrates that it is essential for health authorities to remain vigilant and ensure that the tobacco industry does not play a decision-making role in the process of tobacco legislation and regulation either directly or indirectly. The unprecedented step of requiring approval of implementing regulations for the Nigerian law should not be allowed to become a precedent in other countries.
Multimodal Neuroimaging Differences in Nicotine Abstinent Smokers Versus Satiated Smokers
Authors: Chaarani Bader , Spechler Philip A , Ivanciu Alexandra , Snowe Mitchell , Nickerson Joshua P , Higgins Stephen T , Garavan Hugh
Published: April 2018

Introduction

Research on cigarette smokers suggests cognitive and behavioral impairments. However, much remains unclear how the functional neurobiology of smokers is influenced by nicotine state. Therefore, we sought to determine which state, be it acute nicotine abstinence or satiety, would yield the most robust differences compared with nonsmokers when assessing neurobiological markers of nicotine dependence.

Methods

Smokers (N = 15) and sociodemographically matched nonsmokers (N = 15) were scanned twice using a repeated-measures design. Smokers were scanned after a 24-hour nicotine abstinence and immediately after smoking their usual brand cigarette. The neuroimaging battery included a stop-signal task of response inhibition and pseudocontinuous arterial spin labeling to measure cerebral blood flow (CBF). Whole-brain voxel-wise analyses of covariance were carried out on stop success and stop fail Stop-Signal Task contrasts and CBF maps to assess differences among nonsmokers, abstinent smokers, and satiated smokers. Cluster correction was performed using AFNI’s 3dClustSim to achieve a significance of p < .05.

Results

Smokers exhibited higher brain activation in bilateral inferior frontal gyrus, a brain region known to be involved in inhibitory control, during successful response inhibitions relative to nonsmokers. This effect was significantly higher during nicotine abstinence relative to satiety. Smokers also exhibited lower CBF in the bilateral inferior frontal gyrus than nonsmokers. These hypoperfusions were not different between abstinence and satiety.

Conclusions

These findings converge on alterations in smokers in prefrontal circuits known to be critical for inhibitory control. These effects are present, even when smokers are satiated, but the neural activity required to achieve performance equal to controls is increased when smokers are in acute abstinence.

Implications

Our multimodal neuroimaging study gives neurobiological insights into the cognitive demands of maintaining abstinence and suggests targets for assessing the efficacy of therapeutic interventions.
Prevalence and Evolution of Renal Impairment in People Living With HIV in Rural Tanzania
Authors: Mapesi Herry , Kalinjuma Aneth V , Ngerecha Alphonce , Franzeck Fabian , Hatz Christoph , Tanner Marcel , Mayr Michael , Furrer Hansjakob , Battegay Manuel , Letang Emilio , Weisser Maja , Glass Tracy R ,   KIULARCO Study Group, Asantiel Aschola , Bani Farida , Battegay Manuel , Chale Adolphina , Felger Ingrid , Francis Gideon , Furrer Hansjakob , Gamell Anna , Glass Tracy R , Hatz Christoph , Hwaya Speciosa , Kalinjuma Aneth V , Kasuga Bryson , Katende Andrew , Kimera Namvua , Kisunga Yassin , Klimkait Thomas , Letang Emilio , Luoga Ezekiel , Luwanda Lameck B , Mapesi Herry , Mbwauy Stewart , Mkulila Mengi , Mkumbo Julius , Mkusa Margareth , Mnzava Dorcas K , Mollel Getrud Joseph , Moshi Lilian , Mossad Germana , Mpundunga Dolores , Masawa Ngisi , Mtandanguo Athumani , Myeya Selerine , Nahota Sanula , Ndaki Regina , Ndege Robert C , Ngulukila Agatha , Ntamatungiro Alex John , Nyuri Amina , Paris Daniel , Samson Leila , Sikalengo George , Utzinger Juerg , Tanner Marcel , Vanobberghen Fiona , Wigay John , Weisser Maja
Published: April 2018

Background

We assessed the prevalence, incidence, and predictors of renal impairment among people living with HIV (PLWHIV) in rural Tanzania.

Methods

In a cohort of PLWHIV aged ≥15 years enrolled from January 2013 to June 2016, we assessed the association between renal impairment (estimated glomerural filtration rate < 90 mL/min/1.73 m2) at enrollment and during follow-up with demographic and clinical characteristcis using logistic regression and Cox proportional hazards models.

Results

Of 1093 PLWHIV, 172 (15.7%) had renal impairment at enrollment. Of 921 patients with normal renal function at baseline, 117 (12.7%) developed renal impairment during a median follow-up (interquartile range) of 6.2 (0.4–14.7) months. The incidence of renal impairment was 110 cases per 1000 person-years (95% confidence interval [CI], 92–132). At enrollment, logistic regression identified older age (adjusted odds ratio [aOR], 1.79; 95% CI, 1.52–2.11), hypertension (aOR, 1.84; 95% CI, 1.08–3.15), CD4 count <200 cells/mm3 (aOR, 1.80; 95% CI, 1.23–2.65), and World Health Organization (WHO) stage III/IV (aOR, 3.00; 95% CI, 1.96–4.58) as risk factors for renal impairment. Cox regression model confirmed older age (adjusted hazard ratio [aHR], 1.85; 95% CI, 1.56–2.20) and CD4 count <200 cells/mm3 (aHR, 2.05; 95% CI, 1.36–3.09) to be associated with the development of renal impairment.

Conclusions

Our study found a low prevalence of renal impairment among PLWHIV despite high usage of tenofovir and its association with age, hypertension, low CD4 count, and advanced WHO stage. These important and reassuring safety data stress the significance of noncommunicable disease surveillance in aging HIV populations in sub-Saharan Africa.
Developments of a multi-wavelength spectro-polarimeter on the Domeless Solar Telescope at Hida Observatory
Authors: Anan Tetsu , Huang Yu-Wei , Nakatani Yoshikazu , Ichimoto Kiyoshi , UeNo Satoru , Kimura Goichi , Ninomiya Shota , Okada Sanetaka , Kaneda Naoki
Published: April 2018

To obtain full Stokes spectra in multi-wavelength windows simultaneously, we developed a new spectro-polarimeter on the Domeless Solar Telescope at Hida Observatory. The new polarimeter consists of a 60 cm aperture vacuum telescope on an altazimuth mounting, an image rotator, a high-dispersion spectrograph, and a polarization modulator and an analyzer composed of a continuously rotating waveplate with a retardation that is nearly constant at around 127° in 500–1100 nm. There are also a polarizing beam splitter located close behind the focus of the telescope, fast and large format CMOS cameras, and an infrared camera. A slit spectrograph allows us to obtain spectra in as many wavelength windows as the number of cameras. We characterized the instrumental polarization of the entire system and established a polarization calibration procedure. The cross-talks among the Stokes Q, U, and V have been evaluated to be about 0.06%–1.2%, depending on the degree of the intrinsic polarizations. In a typical observing setup, a sensitivity of 0.03% can be achieved in 20–60 seconds for 500–1100 nm. The new polarimeter is expected to provide a powerful tool for diagnosing the 3D magnetic field and other vector physical quantities in the solar atmosphere.
Searches for H2O masers toward narrow-line Seyfert 1 galaxies
Authors: Hagiwara Yoshiaki , Doi Akihiro , Hachisuka Kazuya , Horiuchi Shinji
Published: April 2018

We present searches for 22 GHz H2O masers toward 36 narrow-line Seyfert 1 galaxies (NLS1s), selected from known NLS1s with $v$sys ≲ 41000 km s−1. Out of the 36 NLS1s in our sample, 11 have been first surveyed in our observations, while the observations of other NLS1s were previously reported in literature. In our survey, no new water maser source from NLS1s was detected at the 3σ rms level of 8.4 mJy to 144 mJy, which depends on different observing conditions or inhomogeneous sensitivities of each observation using three different telescopes. It is likely that the non-detection of new masers in our NLS1 sample is primarily due to insufficient sensitivities of our observations. Including the five known NLS1 masers, the total detection rate of the H2O maser in NLS1s is not remarkably different from that of type 2 Seyfert galaxies or LINERs. However, more extensive and systematic searches of NLS1 would be required for a statistical discussion of the detection rate of the NLS1 maser, compared with that of type 2 Seyferts or LINERs.
Tinnitus, Depression, Anxiety, and Suicide in Recent Veterans: A Retrospective Analysis
Authors: Martz Erin , Jelleberg Chennettée , Dougherty Deborah D. , Wolters Charles , Schneiderman Aaron
Published: April 2018

Objectives:

The purpose of this project was to investigate whether there is an association between tinnitus diagnosis and suicide and whether depression and anxiety strengthen that association. Given that tinnitus is the top service–connected disability among U.S. Veterans (Veterans Benefits Administration, 2016) and that suicide among Veterans has been occurring at a higher frequency as compared with community suicide rates (Hoffmire et al., 2015), the possible associations between tinnitus and suicide will be explored. Co-occurring physical conditions also will be examined to determine if they increase the risk of suicide in the context of tinnitus.

Design:

Administrative health care data related to Operations Enduring Freedom/Iraqi Freedom/New Dawn (OEF/OIF/OND) were used to identify Veterans who accessed the Veterans Administration (VA) health care system from January 1, 2002, to December 31, 2011. Veterans who were deceased as of December 2011 were identified using the National Death Index (NDI) files. Tinnitus cases were followed until either they were deceased or to the end of the study period. The International Classification of Diseases 9th Revision Clinical Modification (ICD-9-CM) codes were used to identify all conditions and diseases. As per mortality research standards, International Classification of Diseases 10th Revision (ICD-10) codes were used to identify cause of death.

Results:

Of 769,934 OEF/OIF/OND Veterans receiving VA care January 2002 to December 2011, 15% (n =116,358) were diagnosed with tinnitus. Of these Veterans diagnosed with tinnitus, 21% were also diagnosed with depression, another 8% with anxiety, and another 17% with both depression and anxiety. Fifty-four percentage were identified as having tinnitus without depression or anxiety. Among individuals with tinnitus, 41.9% had co-occurring hearing loss. Suicide rates were lower among Veterans with tinnitus than Veterans without tinnitus. Co-occurring diagnoses of mental-health conditions did not significantly increase the risk of suicide.

Conclusions:

The study results do not confirm clinical and anecdotal reports that tinnitus could be related to suicide among Veterans. However, tenets from rehabilitation psychology suggest that the onset of chronic impairment or disability does not predict an individual’s subsequent psychological states; other personal attributes may be more influential. Health care professionals, such as audiologists and psychologists, should be cognizant of the associations between tinnitus and mental health issues and be prepared to address the psychological needs of individuals who have tinnitus.
Comparisons of IQ in Children With and Without Cochlear Implants: Longitudinal Findings and Associations With Language
Authors: Cejas Ivette , Mitchell Christine M. , Hoffman Michael , Quittner Alexandra L.
Published: April 2018

Objectives:

To make longitudinal comparisons of intelligence quotient (IQ) in children with cochlear implants (CIs) and typical hearing peers from early in development to the school-age period. Children with additional comorbidities and CIs were also evaluated. To estimate the impact of socioeconomic status and oral language on school-age cognitive performance.

Design:

This longitudinal study evaluated nonverbal IQ in a multicenter, national sample of 147 children with CIs and 75 typically hearing peers. IQ was evaluated at baseline, prior to cochlear implantation, using the Bayley Scales of Infant and Toddler Development and the Leiter International Performance Scale. School-age IQ was assessed using the Wechsler Intelligence Scales for Children. For the current study, only the Perceptual Reasoning and Processing Speed indices were administered. Oral language was evaluated using the Comprehensive Assessment of Spoken Language.

Results:

Children in the CI group scored within the normal range of intelligence at both time points. However, children with additional comorbidities scored significantly worse on the Processing Speed, but not the Perceptual Reasoning Index. Maternal education and language were significantly related to school-age IQ in both groups. Importantly, language was the strongest predictor of intellectual functioning in both children with CIs and normal hearing.

Conclusion:

These results suggest that children using cochlear implants perform similarly to hearing peers on measures of intelligence, but those with severe comorbidities are at-risk for cognitive deficits. Despite the strong link between socioeconomic status and intelligence, this association was no longer significant once spoken language performance was accounted for. These results reveal the important contributions that early intervention programs, which emphasize language and parent training, contribute to cognitive functioning in school-age children with CIs. For families from economically disadvantaged backgrounds, who are at-risk for suboptimal outcomes, these early intervention programs are critical to improve overall functioning.
Laparoscopic Assessment to Determine the Likelihood of Achieving Optimal Cytoreduction in Patients Undergoing Primary Debulking Surgery for Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
Authors: Andikyan Vaagn , Kim Annie , Gretz Herbert F. , Zakashansky Konstantin , Prasad-Hayes Monica , Beddoe Ann-Marie , Dottino Peter , Mandeli John , Chuang Linus
Published: April 2018

Objective:

The objective of this study was to evaluate the safety and efficacy of laparoscopic assessment to determine the likelihood of achieving optimal cytoreduction (OC) in patients undergoing primary debulking surgery (PDS) for ovarian cancer.

Methods:

All patients who underwent diagnostic laparoscopy and PDS at our institution from January 2008 to December 2013 were identified. We determined the likelihood of achieving optimal cytoreduction by laparoscopic assessment based on tumor site, pattern of spread, and disease burden. Sensitivity was defined as the number of patients who achieved optimal cytoreduction after laparoscopic assessment divided by the number of patients with disease deemed resectable by laparoscopy.

Results:

We identified 55 patients during study period. Twenty-one of the 55 patients (38%) were early stage disease. Six (10.9%) patients had disease deemed unresectable and 49 (89.1%) had disease deemed resectable at the time of laparoscopy. OC was achieved in 48 of 49 (97.9%) patients. The sensitivity of laparoscopy in predicting OC was 98% (95% confidence interval, 89.3%-99.9%). The operation was completed laparoscopically in 23 of 49 patients (47%); in 26 of 49 (53%), PDS was performed by laparotomy. There were no port site metastases reported. The rate of postoperative complications was 16%. With a median follow-up of 30 months, the median overall survival was not reached and the 75th percentile for overall survival was 37 months.

Conclusions:

Laparoscopy was shown to have a high sensitivity in predicting OC and is a feasible tool in triaging patients with ovarian cancer. Laparoscopy is not associated with adverse surgical outcomes.