bluuebunny/crossref_metadata_2025 huggingface dataset:
SOMEWHAT gp-CONTINUOUS AND SOMEWHAT gp-IRRESOLUTE FUNCTIONS
Authors: K Rajeshwari , Mirajakar Pallavi S. , Patil Sarika M.
Published: June 2023

The main object of this paper is to study the basic properties of somewhat gp-continuous functions using the concept of gp-open sets in topological spaces. Also, the concept of somewhat gp-open functions and somewhat gpirresolute functions with some counter examples are explained in this paper. Further, the author establishes the relationship between the new classes of functions with other classes of functions by giving examples, counterexamples, properties and characterizations.
MATHEMATICAL ANALYSIS OF SVEIQR MODEL FOR COVID-19
Authors: Kunwar Laxman Bahadur , Verma Vijai Shanker
Published: June 2023

In this paper, we have proposed an SVEIQR compartmental model modifying the classical SEIR model with inclusion of vaccinated and quarantined classes to explain the COVID-19 outbreak mathematically. We have calibrated our model with the daily COVID-19 data reported by the WHO coronavirus dashboard. To observe the disease dynamics of COVID-19, a detailed stability analysis of the proposed SVEIQR model is carried out. Our results show that the disease free equilibrium (DFE) is stable if the basic reproduction number is less than unity and unstable otherwise. Moreover, endemic equilibrium (EE) is found to be stable when certain restrictions hold. The expression for effective reproduction number has been derived analytically and its value is calculated based on the reported cases. Sensitivity analysis of effective reproduction number is performed employing PRCCs and Latin hypercube scheme. We have compared short-term and long-term transmission dynamics of COVID-19 for India with different levels of vaccination and without control strategies. The impact of different degrees of control interventions is ascertained with the numerical simulation of the model.
CERTAIN COSMOLOGICAL MODELS WITH VARIATION OF HUBBLE PARAMETER
Authors: Tiwari Ram Bharosha Ahmad , Srivastava Sudhir Kumar
Published: June 2023

The present paper deals with the FRW-Cosmological Model of universe for W2 flat perfect fluid space time. Einstein field equations with variable cosmological constant (Λ) has been obtained for such spacetime and in order to get the complete cosmological solution the law of variation for Hubble’s parameter is considered. A new class of solution have been discussed for the Einstein field equations with variable cosmological constant in which the pressure, energy density, and cosmological constant Λ are found to be decreasing function of cosmic time. The physical and kinematical properties of models are also discussed.
αg-γ-REGULAR AND αg-γ-NORMAL SPACES
Authors: Rabuni J J Mershia , Balamani N
Published: June 2023

In topology, separation axioms is used to measure how close a topological space is to being metrizable. Spaces that fulfil the axioms are regarded to be nearer to being metrizable than those that do not. In this paper, we introduce new axioms namely αg-γ- regular and αg-γ-normal and analyze their properties in topological spaces. We compare αg-γ- regularity with regularity and αg-γ-normal with normality . Also we obtain the relations between the newly defined spaces and αgγ-Ti ′ (i = 0, 1, 2) spaces.
A NOTE ON THE ORDER AND TYPE OF BICOMPLEX VALUED ENTIRE FUNCTIONS
Authors: Dutta D. , Dey S. , Chakraborty G. , Datta S. K.
Published: June 2023

The main target of this paper is to find out the estimates of the order and type of a bicomplex valued entire function. Also the famous Lucas’s theorem on the zeros of a polynomial is deduced in the light of bicomplex analysis. A result is proved to show that the order and type remain invariant under differentiation of an entire function in C2. Also we prove some results related to Hadamard composition of two entire functions in C2. In fact, we find out here an estimate of the type of the Hadamard composition of two bicomplex valued entire functions. Also we show that the zeros of the derivative of a polynomial P(z) in C2 are contained within the convex hull of the zeros of P(z). Some examples are provided to justify the results obtained here.
Characterization of Paper Mill Effluent and Its Impacts on the Environment
Authors: Shakil Md Shakilur Zaman , Mostafa Md Golam
Published: June 2023

he study aimed to characterize paper mill effluents and determine the quality of surface water in the vicinity of the paper mills using a water quality index to understand the pollution level due to the discharge of untreated effluents. Physicochemical parameters and CCME (Canadian Council of Ministers of the Environment) Water Quality Index (WQI) were used to estimate the degree of pollution in the selected paper mills area in Bogura District of Bangladesh. Moreover, a public perception   survey was conducted in the study area to illustrate the present scenario regarding paper mill effluent discharge. The analytical results revealed that the concentrations of TSS, EC, COD, BOD5, phenols, K, and NO3 – N were higher   than the permissible limit, and the DO level was below the ECR 1997 standard. However, there was no concentrations of heavy metals exceeded the permissible level. The FTIR analysis showed the presence of several toxic pollutants, including lignin, phenol, and halo compound. The CCME WQI showed that sites S-1 and S-2 were ranked as marginal, while site S-3 was ranked as fair. The study observed that the discharge of untreated paper mill effluent has the potential to cause harm to aquatic life and the environment.
CORRUPCIÓN: CONCEPTOS, TIPOLOGÍAS Y SIGNIFICADOS
Authors: Figueroa Mardones Michel
Published: June 2023

La complejidad que se le atribuye a los problemas asociados a la corrupción parten de la ausencia de un marco conceptual común que permita reunir en una idea la diversidad de manifestaciones que tiene dicho fenómeno. En este sentido, este artículo ofrece una revisión bibliográfica de los significados del concepto, las variables que lo componen y las diversas tipologías con el objetivo de ofrecer una visión sistemática de la idea de corrupción. Una de las principales conclusiones es que la corrupción se aborda principalmente como un problema del ejercicio del poder, excluyendo de su conceptualización los comportamientos cotidianos que tienen las personas.
Premio a Mejor Ensayo - ANTICORRUPCIÓN EN LATINOAMÉRICA: DESAFÍOS PARA CHILE EN TRANSPARENCIA Y USO DE TECNOLOGÍAS DE INFORMACIÓN
Authors: Franco Carias María , Navarrete Esparza Marcelo Andrés
Published: June 2023

El estado de la corrupción en Latinoamérica ha sido el centro de la discusión en materia de ética y probidad en sectores públicos y privados de cada país. Los constantes acontecimientos en actos de corrupción han llevado a algunos países de Latinoamérica a desarrollar estrategias anticorrupción basadas en recomendaciones de organismos nacionales e internacionales. Muchas de las recomendaciones concluyen, entre otras cosas, que la transparencia y uso de la tecnología son las principales herramientas en el combate de la corrupción y que se debe promover y desarrollar su implementación. El presente artículo tiene como objetivo general exponer las distintas experiencias respecto a mecanismos de transparencia anticorrupción bajo el uso de tecnologías de información empleados en países latinoamericanos, así como también, presentar los desafíos que debe enfrentar Chile en esta materia.
Facilitators and barriers that influence Nursing Professionals in the Adoption of Information Systems:
Authors: Souza Amaral Neto Arlindo , Montaleão Brum Alves Renato , Ferreira da Silva Mônica , Assis Schmitz Éber , Juarez Alencar Antonio
Published: June 2023

Through a systematic literature review, the current research aimed to acknowledge the main facilitators and barriers that influence the adoption of Information Systems by nursing professionals. Furthermore, it listed the principal theoretical models used to measure technology acceptance and the methods used to perform data collection. It was possible to see that TAM was the model with the highest frequency of appearance. It was also was possible to identify 19 (nineteen) facilitators and 23 (twenty-three) barriers reported in the selected studies. The findings allowed us to understand better how the phenomenon occurs, what can be worked on to improve technology acceptance, and allow new and in-depth studies to be carried out.
Tecnologias da Computação para tratamento e diagnóstico do TDAH
Authors: G. Souza Tainá , Ferreira da Silva Mônica , M. B. Alves Renato , Siqueira Moura Waldir
Published: June 2023

O Transtorno do Déficit de Atenção com Hiperatividade (TDAH) atinge 5% da população infantil, possui diagnóstico difícil de ser realizado, e cujo tratamento apresenta limitações. Novas abordagens são necessárias e as ferramentas computacionais têm auxiliado nestes desafios. Este artigo analisou uma Revisão Sistemática de Literatura sobre o diagnóstico e tratamento do TDAH associados às ferramentas computacionais pormeio da Análise de Conteúdo de Laurence Bardin. A técnica realizada foi a análise estrutural com codificações e categorizações temáticas. Como resultado, verificou-se resultados encontrados na RSL e conhecimentos complementares foram gerados. Por meio destas percepções tornou-se claro que, além dos avanços e lacunas encontrados no material explorado, há conjuntamente uma grande dificuldade nas pesquisas em informática queperpassa a comunicação interdisciplinar.
Um método automático para rotulagem de documentos médicos e categorização
Authors: L. V. de Sousa Orrana , M. V. Magalhães Deborah , E. S. Campelo Victor , R. V. e Silva Romuere
Published: June 2023

A ampla adoção de sistemas para o gerenciamento e registro de documentos médicos (MD) têm gerado um grande volume de dados não estruturados. Tais dados correspondem a texto livre contendo expressões ambíguas para relatar a mesma condição clínica ou procedimentos. Isso torna a tarefa de categorização manual do MD sujeita a erros. Este trabalho visa rotular e classificar MD em português utilizando a rotulação binária (Receita e Outros) e a multiclasse (Receitas, Exames, Atestados e Outros). O n-grama e a frequência do termo - frequência inversa do documento (TF–IDF) foram utilizados na etapa de vetorização do texto. Os resultados alcançados são promissores: apresentaram 0,99 e 0,97 para o Kappa na classificação binária e multiclasse, respectivamente. Assim, com a classificação do MD, é possível fornecer segmentação das informações para gerenciar medicamentos prescritos.
As dimensões de Sistemas de Informação em soluções tecnológicas para transparência organizacional
Authors: Oliveira Zacarias Rodrigo , Silveira Netto Nunes Maria Augusta , Pereira dos Santos Rodrigo
Published: June 2023

A transparência organizacional é um fator que melhora a visão sobre os processos e as informações pelas partes interessadas, sendo apoiada pelos Sistemas de Informação (SI). No entanto, há situações em que a qualidade dos dados disponibilizados é questionada ou a visão sobre esses elementos organizacionais não é garantida de forma satisfatória, ameaçando a confiança e a credibilidade da corporação. O registro de patente incentiva as organizações a inovarem, por meio de soluções tecnológicas, nas formas de operacionalização desse requisito em torno dos SI. Nesse contexto, o objetivo deste artigo é fornecer um panorama das dimensões de SI no contexto de soluções tecnológicas para transparência organizacional em documentos de patente. Para isso, foi conduzido um mapeamento sistemático do estado da técnica em documentos de patentes. Foram encontrados 534 documentos, dos quais 65 permitiram uma visão dos elementos que melhor representam as dimensões: tecnologia (sistemas de gerenciamento de dados e Blockchain), organizações (transparência de informação e de processo) e pessoas (gestores, funcionários, investidores e clientes). Esse estudo contribui para a ampliação da pesquisa no tema de transparência organizacional por meio da divulgação da informação tecnológica à comunidade científica, além de apresentar, para gestores organizacionais, soluções que aplicam estratégias para o alcance dos objetivos corporativos de forma mais eficiente e confiável, a fim de incentivar a inovação na operacionalização da transparência.
Study about Gathering Features in Depression Detection’ Problem with Health Professionals Community
Authors: P. Lima Filho Silas , Ferreira da Silva Mônica , Oliveira Jonice , Ruback Lívia
Published: June 2023

Understanding individuals, social dynamics, and data consumption within social media platforms arouse curiosity and attention in the scientific community and society. The scientific community has shown how a user's mental health can be affected by technology and its digital environment. For example, a user exposed to constant explicit hate speech may suffer an impact on its well-being. There are already efforts in this research area that propose automated solutions to identify users who require professional health attention. However, these solutions do not frequently use the experience and background from the health acknowledgment area in their contribution construction. To fill this gap, we propose a qualitative feature validation with two stages to identify which characteristics are relevant to health professionals, aiming at machine learning and deep learning solutions to depression detection. First, we validate this set of features using a semi-structured interview with three psychologists. Afterward, we apply a survey with domain experts to validate the information extracted from the first stage. This feature validation will allow us to have a detailed view of how functional and practical are the features commonly used in machine-learning-based solutions and how they are close to clinical analysis.
Mitigando Vieses no Aprendizado de Máquina
Authors: Ruback Lívia , Carvalho Denise , Avila Sandra
Published: June 2023

Este artigo apresenta uma análise sociotécnica sobre os vieses inseridos durante o aprendizado de máquina. Descrevemos aqui quatro tipos de vieses: vieses históricos, vieses nos dados, vieses no modelo e vieses de interpretação humana; apontamos como eles podem ser inseridos nos modelos durante o processo de aprendizado e suas implicações sociais e culturais. Apontamos também as direções para mitigar estes vieses, que incluem soluções computacionais, como o balanceamento das bases de dados utilizadas para o treinamento dos modelos e das métricas alternativas para avaliar estes modelos, até soluções não computacionais, regulação do uso dos modelos e políticas para promover a diversidade na tecnologia e na academia.
Il laboratorio ECVAM 3D: un’esperienza di apprendimento laboratoriale in un ambiente digitale tridimensionale e interattivo
Authors: Abbate Emma
Published: June 2023

L’articolo descrive l’applicazione didattica di un ambiente virtuale interattivo: il laboratorio tridimensionale ECVAM sperimentato nel corso dell’anno scolastico 2021/2022 in classi del biennio di un liceo scientifico, ordinamento tradizionale e Biomedico.  La sperimentazione rientra in un progetto pilota, “The three Rs and animal use in Science” (3 Rs), promosso da Scientix, un portale online finanziato dal programma “Horizon 2020” dell’Unione europea per la ricerca e l’innovazione, che raccoglie e presenta progetti europei di educazione STEM e i loro risultati.
Nuovi scenari di progettazione educativa: esperienze di didattica immersiva
Authors: Finestrone Francesca , Limone Pierpaolo , Peconio Guendalina
Published: June 2023

L’adozione della tecnologia per strutturare setting di apprendimento immersivo potrebbe fungere da strumento di potenziamento delle competenze e abilità acquisite e costituisce anche una preziosa risorsa per il potenziamento di quelle più critiche. Porre i sistemi di realtà virtuale immersiva al servizio della didattica rappresenta un’occasione di imparare, sperimentare e sviluppare le proprie potenzialità in un ambiente di apprendimento situato. Il presente paper affronta, quindi, le dimensioni principalmente coinvolte nell’apprendimento mediato dalle realtà immersive, con particolare riferimento allo sviluppo cognitivo e alle abilità sociali. Tale revisione punta a fornire una cornice teorica e metodologica utile a offrire una panoramica sulle esperienze più recenti che la letteratura presenta, in ottica di didattica immersiva.
Didattica immersiva e fragilità: dalla cornice teorica alla sperimentazione in classe
Authors: Iaquinta Rosa
Published: June 2023

Risultano poche le progettazioni didattiche che promuovono interventi riguardanti i bisogni di crescita degli studenti. Di contro, i saperi disciplinari vengono considerati insignificanti per chi fronteggia difficoltà esistenziali. Vivere una condizione di mancanza genera ostacoli nel partecipare alla vita.  La sperimentazione è stata realizzata in una scuola in cui i disagi dei giovani sono influenzati dal territorio geografico, collocato in un’area a rischio dispersione, spopolamento dei luoghi di residenza e a forte processo migratorio. L’esperienza ha fatto ricorso alla didattica immersiva ed è nata dal desiderio di fornire risposte ai bisogni degli studenti di età compresa tra i 14 e i 19 anni. I giovani coinvolti nel progetto manifestavano forme di isolamento fisico e mentale, senso di straniamento dal mondo e rare occasioni di interfacciarsi con altre realtà.
Cosa vuol dire essere “immersi” nell’apprendimento? Il rapporto tra esperienze immersive e apprendimento efficace:
Authors: De Martino Delio , Dicataldo Maria Clara
Published: June 2023

Promosse da uno spot di metaverso, AR e VR sono presentate come tecnologie immersive in grado di rivoluzionare l’apprendimento in ambienti ibridi e virtuali. L’immersività criticata da Platone nel mito della caverna è una tendenza sviluppatasi in tutte le arti fino all’avvento del cinema, che ha gettato le basi per un’immersività più totale, aprendo la strada alle prime sperimentazioni di AR e VR dagli anni Sessanta in poi. Dubbi persistono sull’efficacia didattica. Nonostante i primi studi sembrino molto promettenti, sarà necessario verificare scientificamente se, come per gli altri linguaggi, l’immersività digitale possa avere ricadute per un apprendimento significativo.
Apprendere attraverso il metaverso e la realtà immersiva: nuove prospettive inclusive
Authors: Rossi Martina , Ciletti Michele , Scarinci Alessia , Toto Giusi Antonia
Published: June 2023

Negli ultimi tempi si parla sempre più spesso di metaverso, realtà aumentata e immersiva e delle opportunità didattiche correlate. AR e VR sono parte integrante del metaverso e, negli ultimi mesi, ricercatori ed esperti nel settore dell’Higher Education stanno sperimentando e analizzando il suo utilizzo nei contesti e processi di apprendimento, cercando di comprendere se esso possa risultare utile al fine di fornire nuovi mezzi per una didattica più inclusiva e motivante per i discenti. Ma è davvero possibile apprendere attraverso il metaverso e rendere questo ambiente virtuale e immersivo inclusivo?
Testing innovative preparation tools for immersive virtual environments. A case study in the didactics of Art
Authors: Cavaletti Federica , Terrenghi Ilaria
Published: June 2023

In recent years, the usage of immersive media and Virtual Reality (VR) has become widespread in the education field. VR has been claimed to offer significant benefits in terms of motivation, engagement, and learning outcomes in various disciplines. In this research, we aim to assess the potential of VR in improving the way university students engage with VR art in the classroom. More specifically, we focus on how this technology can be used to provide preliminary knowledge and training for experiencing immersive art, and how this impacts on the students’ level of satisfaction, immersion, and engagement. Our results contribute to advancing the scientific debate on the usage of VR in the education field; additionally, they may be useful to artists and curators, by suggesting an innovative way of introducing the users to immersive artworks.
Experiences, tools, and environments for immersive teaching
Authors: Tinterri Andrea , Dipace Anna , Meletiou-Mavrotheris Maria
Published: June 2023

Editorial of V. 4 No. 7 (2023) of IUL Research.
Programmieren für Nicht-Informatiker leichtgemacht
Authors: Ludwig Andrea
Published: June 2023

Fachkräfte in der Eingliederungshilfe können auch ohne Programmierkenntnisse digitale Assistenzsysteme selbst entwickeln und nachhaltig je nach Bedarf konfigurieren. Projektleiterin Andrea Ludwig bei der Ostfriesischen Beschäftigungs- und Wohnstätten GmbH stellt als praktisches Beispiel ein Pick-by-Light-System vor, das in einem Unternehmen der Eingliederungshilfe eingeführt wurde. Es zeigt: Kostspielige Pick-by-Light-Systeme von der Industrie, die nicht selbstständig von den Fachkräften auf neue Arbeitsschritte angepasst werden können, müssen nicht sein.
Die vielfältigen Facetten der Digitalisierung
Authors: Fitting Tobias
Published: June 2023

Digitalisierung ist ein Überbegriff für viele transformatorische Phänomene. Idealerweise erreichen Organisationen und Unternehmen durch einen klugen Einsatz digitaler Tools eine tatsächliche Arbeitserleichterung für die Mitarbeitenden. Außerdem sind wir gerade im sozialen Bereich mit den Schattenseiten digitaler Welten konfrontiert: von Fake News über Hatespeech und Cybermobbing bis hin zur Gefahr von Hackerangriffen auf IT-Strukturen.
Digitale Führungskräfteentwicklung in der Sozialwirtschaft
Authors: Theune Sarah , Heinzmann Lukas
Published: June 2023

Einer der wirkmächtigsten, jedoch oft unterschätzten Hebel im Bereich Mitarbeitendenbindung und -motivation ist die Führungskräfteentwicklung. Sie lässt sich durch digitale Methoden verbessern. Dieser Beitrag zeigt auf, wie Sozialunternehmen die großen Herausforderungen bei der Befähigung von Führungskräften lösen können. Um das Thema in der Tiefe zu durchdringen und konkrete Unterstützungsangebote machen zu können, haben wir intensive Recherchen sowie Workshops mit Expert:innen und Fokusgruppeninterviews durchgeführt. Gemeinsam mit Kunden konnten in praktischen Projekten zu sogenannten digitalen Lernreisen mit hunderten Führungskräften der Sozialwirtschaft wichtige Erfahrungen gesammelt werden.
Wie Organisationen der Sozialen Arbeit alternative Arbeitsmodelle nutzen können
Authors: Völz Silke
Published: June 2023

Die Fachkräftelücke ist so groß ist wie nie zuvor: Im Bereich der Sozialen Arbeit und Sozialpädagogik fehlten im letzten Jahr schon über 20.000 Expert*innen. Organisationen der Sozialwirtschaft fällt es zunehmend schwer, ausreichend Fachkräfte mit passender Qualifikation zu rekrutieren. Mit gezielten Maßnahmen im Personalmanagement können sie ihre Attraktivität für Fachkräfte erhöhen.
Sozialwirtschaft im Handbetrieb
Authors: Kreidenweis Helmut
Published: June 2023

Natürlich ist IT längst unverzichtbarer Bestandteil vieler Prozesse in Verwaltung, Pflege und Betreuung. Dennoch: Der Einsatz digitaler Technik ist vielerorts alles andere als optimal gestaltet. Die Erhebungen des IT-Reports für die Sozialwirtschaft belegen das seit vielen Jahren, und im Beratungsalltag zeigen sich immer wieder erhebliche Optimierungspotenziale. Wo Potenziale der Automatisierung liegen und wie sich diese heben lassen, erläutert Prof. Helmut Kreidenweis von der Katholischen Universität Eichstätt-Ingolstadt und Mitglied im Beirat der Zeitschrift SOZIALwirtschaft und des Informationsdienstes SOZIALwirtschaft aktuell.
Exome Sequencing Identifies a Novel SGCA Gene Mutation in an Iranian Family with Limb Girdle Muscular Dystrophy: A Case Report
Authors: Khajeh Safieh , Mohammadi Asl Javad , Kazemi Hashem , Neissi Mostafa , Khoshnood Zahra
Published: June 2023

Introduction: Autosomal recessive limb-girdle muscular dystrophy (LGMD) is a rare congenital muscular dystrophy type. This inherited disease is one of the most common diseases resulting in severe physical health problems for infants. Genetic studies have shown that several gene mutations cause limb-girdle muscular dystrophy. This study aimed to report the case of a 10-year-old boy from an Iranian consanguineous family diagnosed with congenital muscular dystrophy and a causative genetic abnormality. Case Presentation: In this report, whole exome sequencing (WES) followed by Sanger sequencing was performed to diagnose the possible genetic defects in patients with LGMD. A novel homozygous disease-causing SGCA gene mutation (p.A107fs:c.319-329del) was found in exon 10 (NM_000023.4). Both parents were heterozygous for the detected mutation. Conclusions: It was concluded that the identified SGCA gene mutation was a pathogenic variant causing autosomal recessive LGMD.
Investigating the Relationship Between the Market Orientation Approach of Pharmaceutical Companies and Their Innovative Performance: The Mediating Role of Dynamic Capabilities and Corporate Social Responsibility
Authors: Shirmohammadi Javad , Azizi Shahriar , Rasekh Hamid Reza , Peiravian Farzad , Polroudi Moghaddam Mahyar
Published: June 2023

Background: Given the intensifying competition, adapting to the market environment and meeting customer demands are crucial aspects of the evolving marketing process. Market orientation (MO) represents an organizational culture encompassing shared beliefs and values that prioritize the customer's role in business planning. Objectives: This study seeks to explore the impact of MO on innovative performance (IP) and the potential mediating role of dynamic capabilities (DC) and corporate social responsibility (CSR) in this relationship. Methods: For this study, a structured quantitative questionnaire was distributed to 100 local pharmaceutical companies, resulting in 300 completed questionnaires. Each questionnaire consisted of four main components, which were filled out by three managers from each company: Chief executive officer (CEO), marketing manager, and research and development manager. The collected data were analyzed using SPSS software and structural equation methods to examine the research questions and hypotheses. Results: According to the study findings, there was a positive correlation between employee age, organizational structure, sales volume, and the presence of private companies with IP. MO, DC, and CSR showed a direct and significant relationship with IP. Moreover, the CSR of the company influenced IP through the mediating role of DC. Market orientation was found to enhance explorative IP, leading to improvements in existing processes and services. Conclusions: Based on the study results, it was found that MO has a direct positive impact on IP, leading to improvements in the company's existing processes through its influence on exploratory performance.
Co-treatment of Naringenin and Ketoprofen-RGD Suppresses Cell Proliferation via Calmodulin/PDE/cAMP/PKA Axis Pathway in Leukemia and Ovarian Cancer Cells
Authors: Afshari Havva , Noori Shokoofe , Shokri Bahareh , Zarghi Afshin
Published: June 2023

Background: Naringenin (Nar) has anti-inflammatory and anticarcinogenic properties. Arginine-glycine- aspartate (RGD) is a tripeptidic sequence used as an integrin ligand and targeting system for delivering chemotherapeutic agents to cancer cells. Objectives: In this study, the inhibitory effects of Nar and ketoprofen-RGD on leukemia and ovarian cancer cells (K562 and SKOV3) were explored for the first time, focusing on their proliferation activity and their anti-inflammatory capacity. Methods: Analyses were conducted on the calmodulin (CaM)-dependent phosphodiesterase 1 (PDE1) activation by ketoprofen-RGD, Nar, and their combination. These drugs’ effects on protein kinase A (PKA) activation, intracellular cyclic adenosine monophosphate (cAMP) level, and PDE1 inhibition were identified. Later, it was also evaluated if ketoprofen-RGD alone or in combination with Nar had anti-inflammatory effects. Results: Nar improved the antagonizing consequences of ketoprofen-RGD on the CaM protein, which hinders PDE1, improving PKA activity and cAMP levels. A mixture of ketoprofen-RGD and Nar and ketoprofen-RGD alone diminished K562 and SKOV3 cell viability through the cAMP/PKA pathway by inhibiting PDE1 and CaM. These two compounds showed anti-inflammatory effects on both cell lines. Conclusions: This study indicated for the first time that combining ketoprofen-RGD and Nar can be a promising anti-inflammatory therapeutic regimen for treating leukemia and ovarian cancer.
Investigating Students’ Logical Thinking Abilities on Chemistry Learning
Authors: Saselah Yeni Ronalisa
Published: June 2023

The purpose of this study is to map students’ logical thinking abilities for learning chemistry. A total of 39 eleventh grade students of SMK-SPP Negeri Samarinda in Agribusiness and Horticulture Program participated in the study. Test of Logical Thinking (TOLT) was administered to determine students’ reasoning abilities. Quantitative descriptive method was used to analyse the data. The result shows that 84,62 % students were found in the concrete level. It consists of 58,97 % male students and 25,64 % female students. Further, 7,69 % male students were found in the transition level and 7,69 % students were found in the formal level, each 2,56 % male and 5,13 % female. From the data, it can be concluded that the majority of students have the concrete level of logical thinking.
Use of NEWS and MMM technologies for diagnostics of NPP components
Authors:   Research Centre Rez, Brom Jaroslav ,   Nuclear Research Institute (NRI, UJV - Rez), Vlcek Peter
Published: June 2023

The paper provides information on the results of the R&D projects of the Research Centre Rez carried out between 2019 and 2022 for the Technological Agency of the Czech Republic as part of the "Perspective Diagnostic Methods" projects. In the first part of this paper, the development of the use of NEWS technology for the detection of cracks in pipelines is described. Results from development on half-pipe and pipe test pieces are presented, as well as results from measurements on the main circulation pipeline and connection pipes up to the first shut-off fitting at NPP Temelín. The method of certification and verification of the methodology is also described. The second part of this paper describes the development of the use of MMM technology to detect the state of tightening of bolts of flange joints. The development focused on determining the dependence of the tension in the bolt and the values obtained by the MMM method, determining the influence of the measurement location for the MMM method on the assessment of the condition of the flange joint, and determining the sensitivity of the method to unsatisfactory flange conditions such as undertightened bolts, overtightened bolts etc. is described. At the end, implementation plans are presented, either for specific applications at the NPP or in a subsequent R&D project.
In-Service Inspection & Repair strategy for newcleo Lead-cooled Fast Reactor
Authors:   newcleo srl, Barbensi Andrea ,   newcleo sa, Genot Jean-Sébastien ,   newcleo srl, Nardi Simone ,   ENEA, Tarantino Mariano
Published: June 2023

Newcleo is designing and building the next generation of nuclear lead-cooled fast reactors (LFRs) fueled with MOX. A fast-spectrum Small Modular Reactor of 30 MWe will be commissioned in 2030 (the Demonstrator) and a First-Of-Kind 200 MWe a few years later. To this end, newcleo develops an incremental strategy, starting first with the consolidation of mature and promising technologies with its own R&D laboratories and collaborations with major institutes and companies. This step aims to demonstrate the applicability of chosen technologies to a full mock-up of the reactor (the Precursor) available in 2026 for experiments. Inclusion of ISI&R (In Service Inspection and Repair) at the earliest stages of designs is a necessity to achieve a sufficient level of maturity and confidence in the technologies, and to increase safety, availability, and preservation of investments of experimental devices and reactors during their whole life.
Round Robin Tests for WWER Heat Exchange Tubes
Authors:   VUJE, Benák Michal ,   VUJE, Krajcovic Roman ,   Nuclear Research Institute (NRI, UJV - Rez), Kopriva Radim ,   Bay Zoltán Nonprofit Ltd. for Applied Research, Szávai Szabolcs ,   Bay Zoltán Nonprofit Ltd. for Applied Research, Takacs Csaba
Published: June 2023

One of the most affected components from the point of view of long-time operation of WWER reactors are heat exchanging tubes of steam generators. With the nominal tube wall thickness of 1,4 mm (WWER440) or 1,5 mm (WWER1000) only and significant consequences of many factors, such as; increasing units power output, the long-time operation, secondary water chemistry and, in some cases, mechanical impact due to dissimilar welds (DN1100) repair, steam generator tubing represents one of the most critical component significantly limiting overall lifetime of many units. New forms of degradations came into being in many of WWER unites, many of them specific for some units only. Therefore, there is a wide accepted need for applying new inspection techniques. As such, these techniques are now on the market, being partially used in some units. Pulled-out tubes from Jaslovske Bohunice units 1 and 2, with real defects, well documented from the point of view of historical eddy current results and results from last inspection, carefully stored and treated, provide the great opportunity for experimental verification of these new, state-of-the art inspection ET techniques (e.g., MRPC, X-Probe, High-speed MRPC etc.).
ÜÇÜNCÜ TARAF YAZILIM BİLEŞENLERİNDEN KAYNAKLANAN ZAYIFLIKLARIN TESPİTİ ve YÖNETİMİNE İLİŞKİN BİR UYGULAMA
Authors: ŞAHİNASLAN Önder , ŞAHİNASLAN Ender , KÜÇÜKALİ Erdi
Published: June 2023

Üçüncü taraf yazılım bileşenlerinin kullanımı her geçen gün artmaktadır. Bu yazılım bileşenleri, şirketlerin hızlı, esnek ve pratik çözümler geliştirmesine yardımcı olurken, birçok güvenlik açığını da bünyesinde barındırabilmektedir. Üçüncü taraf yazılımlara olan talebin artmasına rağmen bu yazılımların kapalı kaynak kod içermesi sebebiyle güvenlik kontrol ve testleri yeterince yapılamamaktadır. Yeterli güvenlik testleri ve kontrolleri yapılmadan bu yazılımların sistemlere entegre edilmesi büyük risk oluşturmaktadır. Bunun sonucunda kurumlar telafisi mümkün olmayan kayıplarla karşı karşıya kalabilmektedir. Bu risk ve kayıpların önüne geçebilmek için üçüncü taraf yazılımların güncel tutulması ve güvenlik açıklarının hızlı bir şekilde tespit edilmesi büyük önem taşımaktadır. Bu kurumların aşması gereken önemli bir sorundur. Bu çalışmada yazılım bileşenlerinden kaynaklanan zafiyetlerin tespiti, analizi, yönetimi, kontrolü, raporlanması ve kurumsal yazılımlarla entegrasyonu ele alınmıştır. Black Duck güvenlik açığı kontrol aracı üzerinde uygulamalı çalışmalar yapılmıştır. Sonuç olarak, uygulama güvenlik araçlarının kullanılması denetim ve kontrol faaliyetlerinin daha hızlı, daha şeffaf ve güvenilir sonuçlara ulaşmasına katkı sağlamaktadır ve uygulama açıklarından kaynaklanan güvenlik risklerinin etkin yönetimine, kontrolüne ve denetimine yardımcı olmaktadır. Aynı zamanda güvenlik ve uyumluluğa da katkıda bulunur, kaynakların etkin kullanımı ile işletmelere çeviklik, verimlilik, karlılık ve rekabet gibi alanlarda avantajlar sunmaktadır. Bu çalışma bilgi teknolojileri, iç kontrol, risk ve denetim profesyonelleri için bir rehber niteliği taşımakta ve literatüre katkı sağlamaktadır.
Absolutism, Utilitarianism and Agent-Relative Constraints
Authors: Nelson Mark T. ,   Philosophy Documentation Center
Published: June 2023

Absolutism—the idea that some kinds of acts are absolutely wrong and must never be done—plays an important role in medical ethics. Nicholas Denyer has defended it from some influential consequentialist critics who have alleged that absolutism is committed to “agent-relative constraints” and therefore intolerably complex and messy. Denyer ingeniously argues that, if there are problems with agent-relative constraints, then they are problems for consequentialism, since it contains agent-relative constraints, too. I show that, despite its ingenuity, Denyer’s argument does not succeed. The defense of absolutism must move to other grounds.
The Influence Of Service Quality And Price On Customer Satisfaction In Sepeda Motor Herman Cv In Nagori Silakkidir
Authors: Divayana Marpaung  , Anton Luvi Siahaan  , Benjamin Albert Simamora
Published: June 2023

This study aims to see how service quality and price influence customer satisfaction at CV Sepeda Motor Herman in Nagori silakkidir. The type of research used in writing this thesis is in this study the authors use quantitative data, because the data to be obtained is in the form of numbers. The location for the implementation of this research was in Nagori Silakkidir Village, Hutabayuraja District, Simalungun Regency on CV Sepeda Motor Herman. The population in this study were all customers who came to visit CV Herman Motorcycles in Nagori Silakkidir during the period January to March 2023 and the sample used in this study was 35 samples. The data collection techniques that can be used in this study are: interviews, observations, documentation, questionnaires. The data analysis technique used in this study was SPSS version 25. Based on the results of data analysis and hypothesis testing about "The Influence of Service Quality and Price on Consumer Satisfaction at CV Herman Motorbikes". So the following conclusions can be drawn: Service quality has a positive and significant influence on customer satisfaction at CV Herman Motorcycles with a count of 3,582 > 2,034 and a significant value of 0.001 <0.05. Price has a positive and significant influence on consumer satisfaction at CV Herman Motorcycles with a tcount of 6,983 > 2,034 and a significant value of 0,000 <0.05. Service quality and price have a positive and significant impact on customer satisfaction at CV Sepeda Motor Herman with an f value of 28.752 > 3.29 and a significance of less than 0.05. (0.000 < 0.05) .
Implementasi Metode Halaqah Pembelajaran Tahfidz Qur’an Peserta Didik Kelas 1 di MI Terpadu Tahfizhul Qur’an Al-Ma’shum
Authors: Kinesti Rakanita Dyah Ayu , Efendi Faza Dzulfikar , Kholilah Nany , Nandifa Aprilia
Published: June 2023

The tahfidz al-Qur'an learning method, along with the development of the times has experienced various innovations. Various methods and models of reciting the Qur'an have emerged which refer to practical, effective and efficient. As was done by the Madrasah Ibtidaiyah Integrated Taḥfīẓhul Qur'an Al-Ma'shum. This study aims to determine the implementation, interest in learning, as well as the features and weaknesses of the halaqah method in learning tahfidz al-Qur'an. This study uses qualitative analysis with data analysis techniques in the form of data reduction, data presentation, and drawing conclusions. The research was conducted on teachers and grade 1 students of Madrasah Ibtidaiyah Integrated Tahfizhul Qur'an Al-Ma'shum using data collection methods in the form of interviews, observation, and documentation. From this study it was found that the implementation of the halaqah method in learning the tahfidz Qur'an of class 1 students of Madrasah Ibtidaiyah Integrated Tahfizhul Qur'an Al-Ma'shum makes students more active and like learning tahfidz Qur'an. Besides that, it can provide opportunities for students to study together with their group mates so that students' abilities can be honed properly.
Peran Bimbingan Konseling Islam dalam Meminimalisasi Bullying antar Teman di Lingkungan Sekolah
Authors: Nilasari Susi , Prahastiwi Eka Danik
Published: June 2023

Bullying is a desire to hurt, which is shown into action and causes someone to suffer. Cases of bullying, especially those perpetrated by children and adolescents in the school environment, are still very high. This is evidenced by data from the Indonesian Child Protection Commission (KPAI) regarding cases of bullying in 2023 which are increasing. In Islam bullying behavior is strictly prohibited and not recommended because it is included in the behavior of demeaning others. One way that can be used to prevent and minimize bullying is the application of Islamic Counseling Guidance. The aim of this research is to find out the role of Islamic Counseling Guidance in minimizing bullying behavior including, what methods are used and how effective or successful it is. This study uses a qualitative approach. The type of research used is library research with the documentation method, namely finding and studying data regarding variables in the form of notes, documents, books, journals and so on. The data sources used are primary and secondary data sources. The data analysis technique used is content analysis method. To test the validity of this research data using a credibility test by increasing persistence, researchers also use source triangulation techniques. Islamic Counseling Guidance has many methods or ways as efforts that can be applied in preventing and minimizing acts of bullying in accordance with the needs of students. Thus, making students show changes in attitudes and behavior in a more positive direction. This indicates that Islamic Counseling is a successful and effective way to minimize acts of bullying between friends at school.
Incontinentia Pigmenti: A Description of a Clinical Case.
Authors:   Pediatrician, Neonatologist, Healthcare Institution of the Republic of Belarus, Kletsk  Central District Hospital, Republic of Belarus., Adamchuk Andrei
Published: June 2023

Bloch-Sulzberger syndrome is a rare genetic disease that has both cutaneous and extra cutaneous manifestations, is more common in females and in most cases, intrauterine male fetuses are detected. There is a report of isolated cases of the presence of the syndrome in males. The pathology manifests itself as a result of the NEMO (nuclear factor-kB essential modulator)/IKK-γ (inhibitor kappa kinase-γ) mutation of the gene located on the Xq28 chromosome. The skin is primarily affected by linearly arranged blisters. In this case, the inflammatory stage may be absent or manifest in utero. Skin manifestations are already present at birth and are difficult to differentiate between non-infectious and non-infectious manifestations. Treatment of skin symptoms of pigment incontinence is often not required as they may resolve spontaneously. However, it should be noted that the early diagnosis of skin manifestations, the significance of which, can be identified by identifying the affected target organs to identify and exclude the detection of fatal complications in the future. This disease is very important for the diagnosis of infectious and non-infectious skin diseases in young children and, in particular, neonatal periods. The presented case is a case from practice in the context of the work of a pediatrician, neonatologist with children with this pathology. In this clinical case, it is possible to trace the clinical picture of the disease in infancy with the further fate of the child for 7 years.
Görsel Sanatlar Dersi Öğretmenlerinin Etik Tutum ve Davranışları
Authors: KIYAT Mehmet Emin , YAYLA Ahmet
Published: June 2023

Bu çalışmanın amacı, görsel sanatlar dersi öğretmenlerinin öğretmenlik meslek etiğine yönelik görüşlerini tespit ederek etik tutum ve davranışlarının eğitim öğretim süreçlerine etkisini ortaya koymaktır. Bu amaç doğrultusunda araştırmada görsel sanatlar öğretmenlerinin etik davranışları araştırılmıştır. Nitel bir çalışma olan araştırmanın çalışma grubunu 2022-2023 eğitim-öğretim yılı, Van ili devlet okullarında hali hazırda görsel sanatlar dersine giren 7 öğretmen oluşturmaktadır. Araştırmanın çalışma grubu amaçlı örneklem yöntemiyle belirlenmiştir. Araştırmada veri toplama aracı olarak yarı yapılandırılmış görüşme formu kullanılmıştır. Görüşmeden elde edilen veriler, nitel veri analizi yöntemlerinden betimsel analiz ile çözümlenmiştir. Ayrıca Borgatti, Everett ve Freeman tarafından geliştirilen Ucinet 6 programı aracılığıyla etik bağlamında görüşmeye katılanların ön plana çıkardıkları kavramlar da görselleştirilerek tanımlayıcı düzeyde analiz yapılmıştır. Araştırma sonucunda, katılımcılar etiğin ve öğretmenlik meslek etiğinin; yazılı olmayan kurallar olduğunu, eşitlik, evrensel ahlaki boyutunun bulunduğunu, sorumlulukların farkında olunması gerektiğini, sevgi ve saygı temelinde geliştiğini / gelişmesi gerektiğini, ayrıca öğretmenlerin tüm meslekleri geliştirdiğinden etik bağlamında çok daha önemli olduğunu belirtmişlerdir. Araştırmada görsel sanatlar öğretmenlerinin mesleki etik ilkeleri konusunda farkındalık düzeylerinin iyi düzeyde olduğu ve görsel sanat eğitiminin, bireyde ve dolayısıyla da toplumda etik ilke ve değerlerinin inşasında oldukça önemli bir yere sahip olduğu sonucuna ulaşılmıştır.
Pengembangan Strategi dan Rencana Pemasaran di Kantor Jasa Akuntan Drs. Suwarno, MM., Ak., CA
Authors: Mauliyah Ika , Barokah Siti Hartinah Hikmatul , Isnaini Zahrotul , Hasanah Maghfirotul
Published: June 2023

Kantor Jasa Akuntan Drs. Suwarno, M.M., Ak., CA perusahaan yang berdiri sejak tahun 2018 menyediakan layanan akuntansi dan pajak selain audit. Permasalahan yang ditemui yaitu kantor jasa akuntan ini dikelola oleh perorangan dan kurangnya upaya pemasaran yang dilakukan oleh pemilik kantor. Solusi dan upaya yang dapat diberikan yaitu melakukan pemasaran baik dari kalangan perusahaan hingga menawarkan pendampingan ujian kompetensi keahlian pada sekolah menengah kejuruan. Berdasarkan hasil penulisan dapat disimpulkan bahwa strategi pemasaran terhadap kegiatan Uji Kompetensi Keahlian di SMK wilayah Jember sangat berpengaruh terhadap kemajuan KJA agar semakin dikenal masyarakat pemilik usaha yang membutuhkan jasa akuntansi
“Pawon Urip”: Pemberdayaan Sosial Ekonomi Masyarakat Desa Pejarakan dengan Tanaman Keluarga
Authors: Hidayat Nur , Nurrohim Muhammad Ficksan , Arifin Mohammmad Luthfi , Agustin Dewi Indriani , Saniyah Fajriyatus
Published: June 2023

Program Pawon Urip di Kabupaten Lumajang bertujuan untuk memberdayakan sektor sosial ekonomi masyarakat desa Pejarakan dengan mengedepankan gizi masyarakat dan ketahanan pangan. Tujuan penelitian dilakukan dengan observasi fisik, observasi sosial, wawancara, dan analisis deskriptif eksploratif. Perekonomian masyarakat Desa Pejarakan tergolong menengah ke bawah yang tidak dapat dihindari dipengaruhi oleh tingkat pendidikan dan dampak pemanfaatan lahan yang tidak efisien. Fenomena sosial masyarakat yang apatis juga tergambar ketika masyarakat tersebut terlalu asyik bekerja dan akhirnya tidak dapat meluangkan waktu untuk bersosialisasi dengan masyarakat lain. Masyarakat memang mendapatkan sesuatu dari menanam pawon urip, meskipun tidak banyak; namun, semua prosedur yang harus diikuti agar hasil dapat dinikmati berpengaruh pada pengetahuan, psikologi, dan ekonomi mereka. Harapan penulis agar masyarakat dapat berdaya dengan tanaman Pawon Urip ini terutama dilandasi oleh konsistensi. Kelanjutan keberlanjutan program ini juga bukan tidak mungkin; dapat menjadi focal point atau bahkan landasan bagi masyarakat untuk terus mengembangkan potensi yang dimiliki saat ini, khususnya dalam aspek sosial ekonomi masyarakat desa Pejarakan yang menjadi fokus utama penelitian
Conductas sexuales según sexo y nivel socioeconómico en adolescentes universitarios de una universidad pública de Chile
Authors: Vargas Chávez Paulina , Henríquez Figueroa Sandra , León Pino José
Published: June 2023

Objetivo principal: Analizar las conductas sexuales según sexo y nivel socioeconómico en universitarios de una Universidad Pública de Chile. Metodología: Se realizó un estudio cuantitativo, observacional analítico, de corte transversal en una muestra 94 estudiantes de primer año de una Universidad Pública de Chile. La recolección de datos se realizó por medio de la aplicación de cuestionario descriptivo de antecedentes sociodemográficos y conductas sexuales. Resultados: El 69,1% de los universitarios iniciaron actividades sexuales cuando tenían 16 o más años. El sexo masculino presentó con mayor frecuencia conductas de riesgo en comparación al sexo femenino. En cuanto a la frecuencia de conductas de riesgo por nivel socioeconómico no se encontraron diferencias estadísticamente significativas. Conclusión principal: Se descarta que el nivel socioeconómico sea un condicionante de las conductas sexuales de riesgo predominantes en el sexo masculino.