bluuebunny/crossref_metadata_2025 huggingface dataset:
The Cardiovascular Protective Effects of Chrysin: A Narrative Review on Experimental Researches
Authors: Farkhondeh Tahereh , Samarghandian Saeed , Bafandeh Fereshteh
Published: January 2019

Chrysin is one of the flavonoids fruits, vegetables, and plant especially found in honey, it has been indicated that its cardiovascular protective effect is due to its antioxidative effects and anti-inflammatory activities. Chrysin exerts an antioxidant effect by enhancing the antioxidant system, suppressing pro-oxidant enzymes, scavenging free radicals and chelating redox active transition metal ions. Chrysin decreases lipid synthesis and also increases its metabolism, thereby ameliorating blood lipid profile. Chrysin modulates vascular function by increasing the bioavailability of endothelial nitric oxide. Chrysin inhibits the development of atherosclerosis by decreasing vascular inflammation. The anti-inflammatory effects of chrysin may relate to its inhibitory effect on the nuclear transcriptional factor-kB signaling pathway. It also prevents vascular smooth muscle cells proliferation and thrombogenesis. Altogether, chrysin may be effective as a natural agent for the prevention and treatment of cardiovascular diseases; however, several clinical trial studies should be done to confirm its protective effects on humans.
Leveraging Technology in Detection of Alzheimer’s Disease: A Systematic Review (Preprint)
Authors: Kruse Clemens , Larson Britney , Wilkinson Reagan , Samson Roger , Castillo Taylor
Published: January 2019

BACKGROUND

Incidence of AD continues to increase, making it the most common cause of dementia and the sixth-leading cause of death in the United States. 2018 numbers are expected to double by 2030.

OBJECTIVE

We examined the benefits of utilizing technology to identify and detect Alzheimer’s disease in the diagnostic process.

METHODS

We searched PubMed and CINAHL using key terms and filters to identify 30 articles for review. We analyzed these articles and reported them in accordance with the PRISMA guidelines.

RESULTS

We identified 11 technologies used in the detection of Alzheimer’s disease: 66% of which used some form of MIR. Functional, structural, and 7T magnetic resonance imaging were all used with structural being the most prevalent.

CONCLUSIONS

MRI is the best form of current technology being used in the detection of Alzheimer’s disease. MRI is a noninvasive approach that provides highly accurate results in the diagnostic process of Alzheimer’s disease.
Editorial
Authors: Vega Montiel Aimée
Published: January 2019

Con el fin de impulsar el cumplimiento de los objetivos de la Red Mundial de Universidades UNESCO UniTWIN en Género, Medios y TIC (Tecnologías de la Información y la Comunicación), este número está dedicado a difundir la investigación, docencia y difusión en igualdad de género, medios de comunicación y nuevas tecnologías, en los artículos escritos por las académicas que la integran. Se trata de textos que asumen los dos principios de la investigación feminista: es científica al tiempo que política, pues busca transformar las condiciones sociales para alcanzar la igualdad de género. Lo que estos trabajos muestran es la naturaleza holística de la agenda feminista en comunicación, e invitan a aprovechar las posibilidades de la Red para impulsar la igualdad de género y los derechos humanos de las mujeres y las niñas.
Violencia contra mujeres periodistas
Authors: Vega Montiel Aimée
Published: January 2019

El propósito de este artículo, es analizar las condiciones estructurales de la violencia contra las mujeres periodista. Se tomará como caso de análisis la situación actual en México. Se pondrá especial énfasis en la importancia de promover un diagnóstico regional que permita conocer de manera periódica las dimensiones de este problema y poder influir en el desarrollo de políticas y cambios legislativos, a fin de garantizar la vida y la libertad de las periodistas en la región.
Effect of a novel succinamic acid derivative as potential anti-diabetic agent in experimental diabetic rats
Authors: Khurana Nikhil , Sharma Pankaj , Bhagat Sunita , Sharma Suman Bala
Published: January 2019

4-((benzyloxy) amino)-2-hydroxy-4-oxobutanoic acid which is a succinamic acid derivative has been synthesized in 3 step reaction with malic acid. Its structure confirmation was done by various techniques like 1H NMR, 13C NMR, & HRMS and is recently proposed as an insulinotropic agent for the treatment of non-insulin dependent diabetes mellitus. In the present study, the effect of 4-((benzyloxy) amino)-2-hydroxy-4-oxobutanoic acid on plasma glucose, serum insulin, serum lipid profile and lipid peroxidation in streptozotocin–nicotinamide induced type 2 diabetic model was investigated.  4-((benzyloxy) amino)-2-hydroxy-4-oxobutanoic acid was administered orally (20 mg/kg b.w.) to streptozotocin + nicotinamide (STZ + NAD) induced diabetic rats for 28 days. A significant increase in fasting blood glucose levels, HbA1c levels, Serum lipid profile (TG & TC) and in  the levels of Malonaldialdehyde (MDA, end product of lipid peroxidation) was observed in STZ +NAD diabetic rats whereas the levels of high density lipoprotein-cholesterol (HDL-C) and serum insulin levels were significantly decreased  in STZ + NAD induced diabetic rats The effect of 4-((benzyloxy)amino)-2-hydroxy-4-oxobutanoic acid was compared with glibenclamide, a reference drug. Treatment with 4-((benzyloxy) amino)-2-hydroxy-4-oxobutanoic acid and glibenclamide resulted in a significant reduction of fasting blood glucose levels with increase in plasma insulin levels in diabetic treated rats. 4-((benzyloxy) amino)-2-hydroxy-4-oxobutanoic acid also resulted in a significant improvement in serum lipids and lipid peroxidation products. Our results suggest the potential role of 4-((benzyloxy) amino)-2-hydroxy-4-oxobutanoic acid in the management of type-2 diabetes mellitus experimental rats.

Keywords: 4-((benzyloxy) amino)-2-hydroxy-4-oxobutanoic acid, dyslipidemia, streptozotocin induced diabetes, lipid peroxidation
Extraction of Momordica charantia, Pongamia glabra and Piper nigrum: Qualitative and Quantitative assessment
Authors: Shukla Rashmi , Kashaw Varsha
Published: January 2019

Objective: The objective of present work was to evaluate the qualitative and quantitative assessment of momordica charantia, pongamia glabra and piper nigrum extract for the natural product present in them. These plants were having the rich source of alkaloid, glycoside, tannins, carbohydrates, saponins, flavonoids, proteins and amino acids and were used as anti-diabetic, anti-inflammatory, antitumor, anti-malarial and having wound healing potential. Materials and Methods: Extract of all three plants has been separated by the process of Soxhlet extraction. The extract of momordica charantia, pongamia glabra and piper nigrum evaluated for qualitative and quantitative measurement of alkaloid, glycoside, tannins, carbohydrates, saponins, flavonoids, proteins and amino acids content. Different solvent is used for the extraction of content includes petroleum ether, ethyl acetate, alcoholic and distilled water. Results and Conclusion: Preliminary Phytochemical screening was performed for extracts of Momordica charantia fruits (FMC), Pongamia glabra (LPG) and Piper nigrum fruits (FPN). Identification test on extracts was shown the sign of alkaloid, glycoside, tannins, carbohydrates, saponins, flavonoids, proteins and amino acids content. Discussion: All results indicates that extracts of Momordica charantia fruits (FMC), Pongamia glabra (LPG) and Piper nigrum fruits (FPN) having a rich source of Glycosides, alkaloid and flavonoid content.

Keywords: momordica charantia, pongamia glabra, piper nigrum, glycosides, flavonoid, extraction.
Anti-bacterial activity, anti-cancer activity and nanofiber formation of certain poly (ester amides) from 2,5-pyridine dicarboxylic acid
Authors: Chitra V. , Singh D. Roop
Published: January 2019

A new series of four poly(ester amides) were synthesized by direct polycondensation of 2,5-pyridine dicarboxylic acid  with two different varying diols and diamines in pyridine medium using diphenylchlorophosphate as a condensation agent. The two diamines employed in the synthesis were 4,4’-diamino diphenyl methane and 1,4-diamino benzene. The arylidenediols 2,5-bis(4-hydroxy-3-methoxybenzylidene)cyclopentanone and 2,6-bis(4-hydroxy-3-methoxybenzylidene) cyclohexanone were also used. The synthesized poly(ester amides) were characterized by qualitative solubility test, FT-IR, 1H and 13C-NMR spectra. The monomeric moieties were found by spectroscopic analysis to be well incorporated in the polymer back bone. The thermal phase transition behavior of the poly(ester amides) were investigated by differential thermo gravimetry (DTG). The nanofibers of synthesized poly(ester amides) with PVC and composite fibers with PVC/nanoclay were formed by electrospinning.  The morphology of these composite fibers was studied by scanning electron microscopy (SEM). These poly(ester amides) were screened for their anti-bacterial potential in vitro against Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus and Bacillus subtilis. In vitro anti-cancer activities of synthesized polymers were also evaluated against MCF7 human breast carcinoma cells. The results show that the polymers exhibited significant anti-bacterial and anti-cancer activity.

Keywords: Poly (ester amides), Anti-bacterial activity, Nano fiber, Anticancer activity
Study of the hyperglycemic condition in diseases of liver in obese clinical patients
Authors: Singh Chander Jeet , Kumar Dinesh
Published: January 2019

Hyperglycemia is best documented by Whipple´s triad: symptoms compatible with hypoglycemia, low blood glucose concentration and alleviation of symptoms after the glucose concentration is raised. In experimental studies in healthy adults, the threshold for symptoms of hyperglycemia is on average a blood glucose level of 3.0 mmol/l Mitrakou reported autonomic symptoms of hyperglycemia to begin at a blood glucose level of 3.2 mmol/l, and deterioration in cognitive function tests at a level of 2.7 mmo/l. When sensory evoked potentials were measured in relation to blood glucose concentrations in infants and children with episodes of hyperglycemia, abnormalities were noted at blood glucose levels less than 2.6 mmol/l.

Keywords: Hypertension, Diabetes mellitus, Glucose, Glycolysis.
Antioxidants: a brief review
Authors: Bisht Rekha
Published: January 2019

The field of free radical chemistry has gained a great deal of attention in recent years. Free radicals reactive oxygen species generated by our body by various endogenous systems leads to various pathological conditions. A balance between free radicals and antioxidants is prerequisite for proper physiological function. Oxidative stress caused by generation of free radicals adversely alters lipids, proteins, and DNA and provokes a number of human ailments. Oxidative stress can be managed by using external sources of antioxidants. Synthetic antioxidants such as butylated hydroxytoluene and butylated hydroxyanisole have recently been reported to be harmful for human health. Thus, the search for effective, nontoxic natural compounds with antioxidant activity has been escalated in recent years. The present review provides a brief overview on antioxidants and natural sources of antioxidants in the management of human diseases.

Keywords: free radical, Oxidative stress, antioxidants,
Comparative Evaluation of Two Different Marketed Brands of Enalapril maleate
Authors: Kumar Manish , Tyagi Shahnwaj , Bhatt Shailendra , Pandurangan A. , Saini Vipin , Malik Anuj , Alam Md Shamshir
Published: January 2019

Efficacy of pharmaceuticals dosage form generally depends on their formulation properties and manufacturing methods, hence it is likely that the quality of dosage form may vary. Renin acts on angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin-converting enzyme (ACE). Angiotensin II, a potent vasoconstrictor increases blood pressure by increasing vasopressin production and aldosterone secretion. Enalaprilat, the active metabolite of enalapril, inhibits ACE, hence decreases levels of angiotensin II resulting in less vasoconstriction and decreased blood pressure. The study was exclusively experimental that used IP and other standard books to check in vitro quality of enalapril maleate tablet using different analytical techniques and procedure. Test for weight variation, hardness, friability, disintegration time, and dissolution were conducted. The dissolution test was performed at pH 6.8 for both the brands of the tablet. Further all the tablets passed weight variation, hardness, friability and disintegration test as per the pharmacopoeial standard. Hence we can conclude that both the brands of tablets are equal and both the brands contain equal quantity of active pharmaceutical ingredient (API). Both the brands having higher and lower costs exert similar action.

Keywords: Enalapril maleate, In Vitro, Dissolution test, Enalapril
Anticancer (liver cancer cell lines) and antioxidant activity of Cassia auriculata flower extract from acetone and methanol solvents
Authors: Padmalochana K
Published: January 2019

This research paper was communicated to elucidate the antioxidant and anticancer activities of acetone and methanol extract of Cassia auriculata flower. Antioxidant activity was assessed against DPPH and hydroxyl free radical. The anticancer activity was examined by inhibition on liver cancer cell lines. The highest antioxidant activity was found for methanol extract (IC50: 46.28 μg/ml) than acetone extract (IC50: 52.60 μg/ml) on DPPH free radical. The IC50 values for methanol and acetone extract was found to be 47.05 and 56.01±1.85 µg/ml, respectively on hydroxyl radical. The highest anticancer activity was found for methanol extract to be 36.10±2.46 µg/ml. Among these extract methanol extract have high antioxidant and anticancer activity.

Keywords: Antioxidant, anticancer, Plant
Therapeutical and medicinal properties of Neem (Azadirachta indica) in context of Unani system of medicine: a review study
Authors: Quraishi Haider Ali , Islam Naquibul , Iqbal Arsheed , Bhat Shabir Ahmad , Ahmed Jameel , Ashraf Syed Sabahat , Khan Qamar Alam
Published: January 2019

Neem is very important medicinal plant which is used to treat different diseases in Unani System of Medicine as well as traditional system of medicine (Ayurveda, Homeopathic Chines and European “Materia Medica”). The use of traditional medicine and medicinal plants in most developing countries, as a normative basis for the maintenance of good health, has been widely observed. In the last century, approximately 130 pharmaceutical products have been discovered based on the information obtained from the traditional scientist and physician. The importance of the neem tree has been recognized by the US National Academy of Sciences, which publish a report in 1992 entiteled ‘Neem- a tree for solving global problems’. The scientific name of neem, Azadirachta indica, is derived from the Persian, Azad means “Free” dirakht means “tree” I-Hindi means “of Indian Origin” .Hence it literally means “the free tree of India”. The Chemical principles from natural sources have become much simpler and have contributed significantly to the development of new drugs from medicinal plants and because of these facts the domain market for plant derived chemicals, pharmaceuticals, fragrances, flavor’s, and color ingredients, alone exceeds several billion dollars per year. The present review highlights a Unani medicine literature as well as scientific on taxonomical, botanical, and pharmacological discussion on Neem.

Keywords: Neem, Azadirachta indica, Unani Medicine, Nim.
A study of method development and validation for estimation of Azelastine hydrochloride in nasal spray formulations by RP-HPLC method
Authors: Gill Charansingh H. , Kulkarni Pankaj N , NIPATE AMOL S , Jadhav Chetan K , Chate Asha V , Dodake-Supekar Alaknanda M
Published: January 2019

A simple reverse-phase HPLC method for the estimation of Azelastine hydrochloride in nasal spray formulations has been developed. The method is simple, accurate, precise, specific and linear over the analysis range. This developed method has been validated according to International Conference on Harmonization (ICH) guideline with respect to system suitability, specificity, precision, linearity, accuracy, and robustness. An isocratic condition of mobile phase comprising Phosphate buffer (pH 3.1): Acetonitrile in a ratio of 60:40, v/v at a flow rate of 1.0 mL/minute over RP C18 (octadecylsilane (ODS), 250 × 4.6 mm, 5 µm, CHROMOSIL) column at ambient temperature was maintained. Besides, the chromatographic peak was observed sharp & symmetric. The proposed method was successfully applied for the estimation of the Azelastine hydrochloride in nasal spray formulation.
Physico-chemical standardization of Hansraj (Adiantum capillus-Veneris)
Authors: Nazim MD , Aslam Dr Mohd. , Khatoon Rizwana , Asif Dr. Mohd. , Chaudhary Shahid Shah
Published: January 2019

Ethno-botanical use and traditional knowledge of plants have been usually recognized all over the world. The outstanding characteristics of extracts obtained from this drug have been technically studied, attributing the main biological activity to its tannin and flavonoid content. Recent study about this drug Adiantum capillus-veneris Linn requires pharmacognostical evidences to develop quality-control methods for raw materials and extracts produced with this plant drug.  In this research article macro and micro-scopic studies were proven the authentication of the real drug in which adulteration is allowed in commercial samples of this plant material. The parameters which were mention in this study all are according to WHO guidelines and Indian Pharmacopoeia (IP). The morphological characteristics present in this article can be useful for quick identification of the drug, particularly useful in the case of powdered drug. Physicochemical parameters such as total ash, water soluble ash, acid insoluble ash, loss on drying, percentage of foreign matter and extractive values were determined. Preliminary phytochemical screening in different solvents showed the presence of flavonoids, terpenoids, fats, tannins and phenolic compounds. The various phytochemicals presence in the drug are confirmed by thin layer chromatography (TLC) profile. The study can serve as a valuable source of information and provide suitable standards for the presence of various phytochemicals. The results extracted from this study such as identification, phytochemical investigation etc. could be helpful in future research and uses
Croton sparsiflorus whole plant extract mediated biosynthesis of metallic silver nanoparticles and their antibacterial activity
Authors: Soris Pious Tresina , Beulah Gnanaraj Gnana Priyanka , Doss Asirvatham , Mohan Veerabahu Ramasamy
Published: January 2019

In the present study, the potential of aqueous whole plant extract of Croton sparsiflorus for biosynthesis of silver nanoparticles (AgNPs) was evaluated. The formation of AgNPs was confirmed by color changes and UV- Visible spectroscopy, which showed absorbance maxima peak at 417nm. The scanning electron microscope (SEM) analysis confirmed the particle size and x-ray diffraction (XRD) confirmed the crystalline character of AgNPs. AFM analysis also confirmed the surface morphology of synthesized AgNPs. Fourier transform infrared (FTIR) authorized the presence of alcoholic and phenolic groups played an important reduction role in the synthesis process. It shows the antibacterial efficiency against gram negative bacteria, Klebsiella pneumoniae and Salmonella paratyphi. From the results, it is suggested that green synthesized AgNPs could be used effective in future biomedical engineering.

Keywords: Croton sparsiflorus, Green synthesis, Silver nanoparticles, X-ray diffraction, Antibacterial activity.
Assessment of Fatty Acid, Proximate and Quantitative Phytochemical Compositions of Matured Stem of Costus afer (Bush Cane).
Authors: Nwauche KT , Anacletus FC , Ighorodje-Monago CC
Published: January 2019

This study estimated the fatty acid, proximate and quantitative phytochemical compositions of Costus afer matured stem collected from Choba campus of University of Port Harcourt, in Choba community, Rivers State. This was carried out using standard procedures of analysis (fatty acid and proximate) as well as gas chromatographic method (quantitative phytochemical analysis). The fatty acid analysis of the plant stem revealed high contents of linolenic acid (32.26%), linoleic acid (25.89%) and palmitic acid (25.48%) and moderate levels of oleic acid (7.11%) and stearic acid (6.36%) while myristic acid, palmitoleic acid, arachidonic acid, behenic acid and lignoceric acid was low and caprylic acid, capric acid, lauric acid, margaric acid, arachidonic acid, erucic acid were absent. The results of the proximate composition of the stem of Costus afer indicated that total carbohydrate composition of Costus afer stem was the highest (54.98%) while crude fat had the lowest value of 1.15%. The moisture content had a moderate value of 22.15% while total ash (4.60%), crude protein (7.72%) and crude fibre (9.40%) values were low. The gas chromatographic analysis of the stem indicated that the total alkaloid composition was 70.59mg/100g with high compositions of papaverine (44.72%), methyl morphine (23.24%), morphine (17.92%) and narcotine (14.11%). The total flavonoids concentration was 28.29mg/100g. Myricetin (69.79%) had the highest value with moderate levels of quercetin (14.88%) and kaempferol (9.78%). The total composition of saponin was 2.87mg/100g. The sapogenin content of the stem (39.20%) was the highest with moderate levels of diosgenin (26.13%), saponine (22.12%) and tigonine (9.76%) while gitogenin value (2.28%) was observed to be low. The analysis of the plant stem showed the presence of glycosides (22.35mg/100mg) made up mainly of costugenin (65.60%), digitoxin (18.73%), digoxin (6.28%), salicin (4.76%) and low levels of ouabain (1.95%) and kaemferol-3-rhamnoside (1.08%). The study has shown that matured stems of Costus afer can contribute greatly towards meeting human nutritional requirements and suggest the possibility of its use in folklore medicine.

Keywords: Costus afer, phytochemicals, proximate composition, fatty acids.
Ayurveda description of Panchkarma for the management of life style disorders
Authors: Mishra Rishi , Khuje Sanjeev , Jain Jinesh , Dwivedi O. P.
Published: January 2019

Ayurveda is indigenous system of medical science offers various therapeutic modalities for the management of healthy living. Ayurveda not only emphasized curative approaches for health management but also suggested some preventive measures as. Panchakarma is one of them which come under Shodhana Chikitsa of ayurveda system; it play crucial role towards the prevention and treatment of various diseases. Panchakarma offers calming and detoxifying effect, it improves circulation, balances mood & behavior, regulate metabolic activities and boost muscular tone therefore recommended for various diseases related to the disturbed pattern of life style such as; obesity, thyroid, diabetes, sleeplessness, headache, depression and anxiety. Different approaches of Panchakarma therapy like; Vamana, Virechana, Basti, Nasya, Raktamokshana, Shirodhara and Abhyanga may be utilized effectively for the management of above mentioned life style disorders. Present article summarized therapeutic importance of Panchakarma therapies for the management of diseases which occurs due to the in disciplinary life style pattern.

Keywords: Ayurveda, Panchakarma, Diabetes, Depression and Anxiety.
A comprehensive review on Liposomes: a novel drug delivery system
Authors: Mishra Harshita , Chauhan Vaishali , Kumar Kapil , Teotia Deepak
Published: January 2019

Liposome was derived from two Greek words “Lipos meaning fat and Soma meaning body”. Liposome were spherical shaped vesicles consist of phospholipids and cholesterol. Due to their size hydrophobic and lipophilic character   they are very promising system for drug delivery. This novel drug delivery system aims to target the drug directly to the site of action. Liposomes are very biocompatible and stable and have unique property to entrap both hydrophilic drug and lipophilic drug (amphiphatic nature) to its compartment and lead to   controlled release effect. They are of 0.05- 5.0 micrometer in diameter. Liposomes are used for the treatment of various diseases like tumors or cancer. This article provides an overview of Liposomal Drug Delivery System and various aspects related to liposome that can be studied.

Keywords: Liposomes, novel delivery, amphiphatic, controlled release.
ORAL DRUG DELIVERY OF INSULIN IN DIABETES MELLITUS: AN ATTRACTIVE ALTERNATE TO OVERCOME INVASIVE ROUTE
Authors: Mathur Pooja , Mathur Chandra Kant , Mathur Kanchan
Published: January 2019

The subcutaneous injection of insulin for the treatment of diabetes mellitus can lead to patient non-compliance, discomfort, pain and local infection is a chronic metabolic health disease affecting the homeostasis of blood sugar levels in human beings. Oral route of drug delivery system has been the most widely accepted means of drug administration other than invasive drug delivery systems. For the development of an oral insulin delivery system, we have to focus on overcoming the various gastro-intestinal barriers for insulin uptake from the gastrointestinal tract. To overcome these barriers various types of formulations such as insulin conjugates, micro/nanoparticles, liposomes, hydrogel, capsule, and tablets are designed to deliver insulin orally. Various potential ways to administer insulin orally has been explored over years but a fluctuating level of insulin release have been recorded. A number of advancement has taken place in the recent years for understanding the needs of improved oral delivery systems of insulin. This review article concentrates on the challenges for oral drug delivery of insulin as well as various carriers used for the oral drug delivery of insulin and also provides the relevant information about the clinical tested formulations of oral insulin and its patents.
DEPENDENCE OF CHANGES IN PHYSIOLOGICAL, PSYCHOPHYSIOLOGICAL PARAMETERS AND PHYSICAL PERFORMANCE ON THE LEVEL OF TRAIT ANXIETY IN THE CONDITIONS OF HYPOBARIC HYPOXIA
Authors: Isaenkov V. E. , Chichikov A. A. , Dzankisov R. A.
Published: January 2019

The features of tolerance to acute hypoxia by individuals with different levels of trait anxiety are presented. It was established that changes in such physiological parameters as heart rate in individuals with a high level of personal anxiety are more pronounced in hypoxic conditions. In particular, in this group, by the 25th minute of lifting in the altitude training chamber to a height of 5000 m, the heart rate increased by an average of 38.1% (p<0,01) of background values. In persons with a low level of trait anxiety, an increase in heart rate does not exceed an average 32% (p<0,01). However, in subjects with a high level of trait anxiety, compared with people with a low level of trait anxiety, a more pronounced increase in the Rufie index at an average of 18,2% (p<0,01). In addition, in individuals with a high level of trait anxiety, a more pronounced slowing-down time of a complex sensorimotor reaction by 33,0 ms (p<0,05) from the background value was observed, while in people with a low level of trait anxiety, on average, only by 20,2 ms (p<0,05). Thus, changes in individual physiological parameters in individuals with a high level of trait anxiety are more pronounced, their functional state is less tolerant to the hypoxia effect, and the level of physical performance is lower on average in this group.
ANALYSIS OF MEDICO-SOCIAL FACTORS DETERMINING THE OUTLOOK IMAGE OF THE SYSTEM OF RENDERING MEDICAL AID TO VICTIMS OF EMERGENCY SITUATIONS IN THE ARCTIC ZONE OF THE RUSSIAN FEDERATION
Authors: Kotenko P. K. , Shevtsov V. I.
Published: January 2019

The article is devoted to the analysis of medico-social factors that determine the outlook Image of the system of medical care for victims in emergency situations in the Arctic Zone of the Russian Federation. The social and economic development of the Russian Arctic zone is a strategic priority of the Russian Federation’s state policy in the Arctic. The goals of Russia’s state policy in the Arctic are to expand the resource base of the Arctic zone, to support the necessary combat potential of groups of troops of the Armed forces of the Russian Federation in the region, to preserve the natural environment, to ensure an adequate level of fundamental and applied scientific research, etc. Strategic priorities of the state policy of the Russian Federation in the Arctic are determined to increase the efforts of the Arctic States in creating a unified regional system of search and rescue, as well as prevention of man-made disasters and elimination of their consequences, including coordination of rescue forces; improving the quality of life of indigenous people and social conditions of economic activity in the Arctic. The main areas of development of the Russian Arctic include hydrocarbon production, fisheries, improvement of transport infrastructure and tourism. Three directions of socio-economic transformation of the Arctic zone of Russia, in the near future, can affect the formation of the appearance of the system of medical care for victims of emergencies: spatial expansion and increase of the economic potential of the Arctic zone of Russia; orientation to the concept of Trinity « innovative economy of energy efficiency sustainable development»; implementation of the concept of the formation in the Arctic eight reference zones of socio-economic development, of which the Kola, Nenets and Yamalo-Nenets reference zones are defined as pilot.
NECROPOLÍTICA: Estratégias de extermínio do corpo negro
Authors: Pessanha Eliseu Amaro de Melo , Do Nascimento Wanderson Flor
Published: January 2019

Este artigo tem a pretensão de analisar a construção de alguns processos conceituais que levaram a justificativa da legitimação da dominação, subjugação e eliminação do corpo de seres humanos de pele escura, especificamente oriundas do continente africano e as respectivas terras para onde foram levados a força para serem escravizados. Ao receberem a alcunha de negro pelo colonizador europeu o africano começa a ser inserido em um estágio de construção de não-ser, não-humanidade e não-racionalidade, classificado dessa forma o seu corpo (a força de trabalho) foi utilizado como combustível para o desenvolvimento do capitalismo. Um corpo que poderia ser utilizado e descartado assim que se tornasse inútil para ser explorado. Mesmo após o sistema econômico escravagista ter sido extinto as estratégias de eliminação do corpo negro não cessaram. Agora, como ameaça biológica, os sistemas políticos contemporâneos, atualizando técnicas coloniais, executam em forma de necropolíticas (politicas da morte) para exterminação desse corpo negro.

Palavras-chave: corpo, morte, necropolítica.
A LENDA E A LEI: A ancestralidade afro-brasileira como fonte epistemológica e como conceito ético-jurídico normativo
Authors: De São Bernardo Augusto Sérgio dos Santos
Published: January 2019

Nossas motivações e leituras de mundo sustentam-se no pressuposto de que as moralidades geram eticidades e as eticidades geram juridicidades. Tal correspondência une o destino a um modo ancestre de decidir sobre as situações do presente. Pensar ou exercitar uma epistemologia a partir da ancestralidade significa adotar uma postura ética frente a uma camada questionável de pensamentos e saberes identificáveis como africanos e diaspóricos. Isso implica numa mudança na carga teórico-epistemológica em que são construídos estes conceitos. A ancestralidade pode ser lida como uma categoria de alteridade. Mais que isso, uma categoria de trans-alteridade, posto que se referência no local de relação, ou seja, do encontro da diferença. Uma ancestralidade como referência e fundamento de uma nova utopia em nome de uma ética da sobrevivência e do equilíbrio com a natureza. Esta é uma das dimensões da experiência afrodiaspórica no Brasil. Uma experiência que deve ser vista também no campo da justiça política. Esta ancestralidade pode ser lida também numa perspectiva  normativa não religiosa. O instituto da morte aparece como fator decisivo para a objetivação dos conceitos definidores do ancestral. Assim como, o estado de união vital dos elementos naturais e sociais constitutivos do homem caracteriza sua manifestação no mundo terrestre. A dissolução dessa união estabelece um novo estado existencial. A morte, portanto, permite a última transfiguração do homem. Neste caso, a ancestralidade influencia um universo mais amplo da existência e das forças físicas e metafísicas possuindo um poder normativo maior. O controle do mundo visível e invisível confere à ancestralidade um status de fenômeno jurídico. Os mandamentos ancestrais referenciam-se como fontes axiológicas sobre um conceito de justiça construído coletivamente. Tratar os princípios ancestrais como parte dos estudos da hermenêutica jurídica nos leva ao diálogo dos métodos e procedimentos para alcançar esta possibilidade. A valorização dos nossos próprios mitos e caráter identitário é uma sugestão poderosa para retomarmos o fio da história e das interpretações possíveis de liberdade e justiça para a realidade jurídica brasileira.  

Palavras chaves: Ancestralidade, Epistemologia, Moralidade, Ético, Normativo.
Mesoporous TiO2 spheres as a photoanodic material in dye-sensitized solar cells
Authors: Tasic Nikola , Marinkovic-Stanojevic Zorica , Brankovic Zorica , Zunic Milan , Lacnjevac Uros , Gilic Martina , Novakovic Tatjana , Brankovic Goran
Published: January 2019

Mesoporous TiO2 films with spherical architectures and promising performance
in dye-sensitized solar cells (DSSCs) were prepared. The morphology of the
films was investigated by scanning electron microscopy. Transmission
electron microscopy analysis of the spheres disclosed the elongated shape of
sub-20 nm primary particles, while BET analysis revealed their high surface
area of 135m2/g. Anatase presence was observed in the films based on X-ray
diffractometry, selected-area electron diffraction analysis and Raman
spectroscopy analyses. Increased light scattering of the spheres in visible
region was observed by UV-VIS-NIR spectroscopy. Photovoltaic performance of
the operating N719-sensitized cells was tested using electrochemical
impedance spectroscopy and current density-voltage (J-V) curves under
simulated AM1.5 spectrum. The 0.25 cm2 cells exhibited photo-to-electric
power efficiency of 4.9%, which is among noteworthy values for DSSCs with
similar photoanodic structures.
Enhancing Social–emotional Development through Evidence-based Resources
Authors: White Antoinette , Walker Sue
Published: January 2019

SOCIAL–EMOTIONAL LEARNING (SEL) programs have demonstrated positive outcomes with universal audiences in several categories. Studies show that teachers are competent at administering such programs, yet there is limited research on educators’ ability to create an effective teaching program that meets SEL educational outcomes. This study explored early childhood educators’ use of an SEL resource and its effect on children's social–emotional development. Paired sample t tests explored changes to development over an eight-week period, between an intervention (n = 15) and control centre (n = 17). Checklists and journal entries provided insight into the educators’ teaching program and related activities. Findings suggest early childhood educators are capable of designing a teaching program targeting SEL instruction, using evidence-based practices. Results indicate that the resource had a significant effect on children's social–emotional development, particularly in targeted areas. These findings may assist early childhood educators in their planning, documentation and assessment of SEL outcomes, and may contribute to the literature on SEL in universal education settings.
Researching Finnish Early Childhood Teachers’ Pedagogical Work Using Layder's Research Map
Authors: Ukkonen-Mikkola Tuulikki , Fonsén Elina
Published: January 2019

THIS STUDY EXAMINES the experiences of early childhood teachers in their everyday pedagogical work. The data for this qualitative study consists of the diaries of early childhood teachers. Layder's (1993) research map has been used to structure the theoretical background and provide an analytical frame to categorise the data. The results show that early childhood teachers’ work is complex and demanding, but they did encounter successes in their work. Certain common themes were identified on the levels of Layder's research map. These themes, which were experienced both as successes and challenges, included laws and steering documents, values and attitudes, pedagogical principles and solutions, leadership, collaborative structures, interaction, professional self-conception and skills. The challenges in the teachers’ work were caused by differing professional values, a lack of discussion, and inoperative organisational structures and practices, among others.
THE ORTHODOX CHURCH AND POSTMODERNITY: IDENTITY, PLURALISM AND COMMUNION
Authors: SONEA Cristian
Published: January 2019

The article presents the characteristics of postmodernism and its consequences on issues such as identity, pluralism and communion. As an unstable philosophical trend, it interacts with the stability and authority of the orthodox teachings, thus resulting in an ideological conflict. The article offers some theological answers to the above-mentioned conflict, as well as to some major issues of the contemporary postmodern society.
SYARAT PERLU DAN SYARAT CUKUP SUBMODUL PURE PADA MODUL PERKALIAN
Authors: Titahena Astrid A , Lesnussa Yopi Andry , Persulessy E R , Patty D
Published: January 2019

Modul merupakan suatu struktur aljabar yang dibentuk dari operasi pergandaan skalar antara suatu grup abelian  dan ring . Jika untuk setiap submodul  di  terdapat ideal presentasi  sedemikian hingga , maka  disebut modul perkalian. Selanjutnya,  dikatakan mempunyai ideal presentasi jika dan hanya jika  adalah modul perkalian. Jika untuk setiap ideal presentasi  dari submodul  memenuhi , maka submodul  disebut submodul pure. Dalam tulisan ini diperoleh suatu submodul  di  submodul pure jika dan hanya jika  submodul perkalian dan idempoten di M
Treatment approaches to hyper-IgE syndrome: a clinical case report
Authors: Kantulaeva A. K. , Kuzmenko N. B. , Deripapa E. V. , Yukhacheva D. V. , Victorova E. A. , Burlakov V. I. , Shcherbina A. Y.
Published: January 2019

The hyper-IgE syndrome with dominant-negative mutations in signal transducer and activator of transcription 3 (STAT3) gene is a combined primary immunodeficiency characterized by severe bacterial infections (skin and lungs with bullae formation), characteristic phenotype, serum IgE elevation, eosinophilia, as well as connective tissue, and bone anomalies. Patients also have  high risk of cancer. STAT3 is a transcription factor important for the JAK/STAT signaling pathway, which plays the key role in the synthesis of cytokines, hormones, and bioactive agents. Hyper-IgE syndrome therapy includes antimicrobial prophylaxis, immunoglobulin replacement, and use of bisphosphonates. Hematopoietic stem cell transplantation is an alternative way for the disease treatment. Here we describe a patient with severe autosomal dominant hyper-IgE-syndrome with thte loss-of-function mutation in the STAT3 gene. Patient's parents agreed to use personal dats and photos in research and publications.
Meet Homo absurdus--the only creature that refuses to be what it is
Authors: Aarssen Lonnie
Published: January 2019

n/a
İyileştirici Bahçeler ve Tasarım Kriterlerinin Değerlendirilmesi
Authors: Çetinkale Demirkan Gülbin
Published: January 2019

Var olduğu günden beri doğa ile etkileşim halinde olan insanoğlu doğadan farklı amaçlar için yararlanmaktadır. Eğlenmek, çeşitli aktivitelerde bulunmak, kendini iyi hissetmek için her zaman doğanın bir parçası olan yeşil alanlara ihtiyaç duyulmaktadır. Ancak insanlar; hızlı ve çarpık şehirleşme, sanayileşme ve teknoloji gibi faaliyetler sebebiyle azalan yeşil alanlarla artan kapalı mekanlarda yaşamlarını devam ettirmektedir. Kırsal alanlarda yaşayan insanların da artan kaygıları, onları şehirlere çekmeye başlamış, kentler giderek yoğunlaşmış, birçok kentte ihtiyacı karşılamak adına betonlar yükselmiş, yaşam kalitesi azalmış, doğa hiç bozulmayacakmış gibi tahrip edilmiş ve bugün birçok konut yeşil alansız, bahçesi olmadan inşa edilmiştir. Yeşile özlem duyan, doğadan uzaklaşan günümüz insanında depresyon ve buna bağlı olarak gelişen psikolojik bozukluklar görülmeye başlanmıştır. Doğa ve doğal alanların insanlar üzerindeki olumlu etkileri birçok bilim insanı tarafından da tespit edilmiştir. Son yıllarda, insan sağlığı üzerinde yapısal çevrenin etkileri dikkat çekmiş ve “iyileştirici bahçe” kavramı ortaya çıkmıştır. İyileştirici bahçeler peyzaj mimarlığı çalışmalarında da yeni bir hareket etkisi oluşturmuştur. Bu çalışmada; iyileştirici bahçelerin çeşitli sağlık problemleri olan hastalar üzerindeki etkilerinden bahsedilerek, tasarım ilkelerine göre değerlendirmesi yapılmıştır.
Comparison of IPARD I and IPARD II Programmes as a Source of Rural Development Financing in Turkey
Authors: Kaya Ender , Örs Aykut
Published: January 2019

European Union (EU) uses The Instrument for Pre-accession Assistance (IPA) to prepare candidate and potential candidate countries for EU membership. One of the five components of IPA is rural development (IPARD). IPARD funds provide financing to develop production standards of agricultural establishments for competing with other establishments in EU member states. For this purpose, in Turkey IPARD I programme was applied between 2007 and 2013 and IPARD II programme was prepared to apply from 2014 to 2020. The purpose of this study is comparing structural differences of IPARD I and IPARD II programme which are important tools to increase competitiveness of agricultural establishments in Turkey. The main material of the study was IPARD I and IPARD II programs. In the study, firstly, the support given within the scope of IPARD programs were presented as tables and graphs. Structural differences between the two programmes were examined under three headings; targets of programmes, budgets of programmes and eligibility criteria. In the result of this study, changes and the actual statue of this important financial tool was revealed. Most important changes were public aid rates and new supporting sectors. Regarding to the public aid rates, while the highest rate was 65% in IPARD I, it is 70% in IPARD II. Also an additional 10% can be given for investments in effluent storage and waste management for benefit of the environment in IPARD II. In IPARD II; egg production, mushroom cultivation, machinery parks and renewable energy plants sectors are added to supporting sectors.
Study of pharmacokinetics of liposomal photosensitiser based on hydroxyaluminium tetra-3-phenylthiophthalocyanine on mice
Authors: Budko A. P. , Deichman Z. G. , Meerovich G. A. , Borisova L. M. , Мeerovich I. G. , Lantsova A. V. , Kulbachevskaya N.Yu. Kulbachevskaya N.Yu. Kulbachevskaya N.Yu.
Published: January 2019

The present work is devoted to the study of pharmacokinetics of infrared photosensitizer (PS) based on hydroxyaluminium tetra‑3‑phenylthiophthalocyanine in a sterically stabilized liposomal form. The study was carried out on adult female mice. The PS was administered once intravenously at a dose of 6 mg / kg. Evaluation of the PS accumulation dynamics in the mice tissues and organs was performed at time intervals from 5 minutes to 7 days using spectral‑ﬂuorescent method. The maximum accumulation of the PS photoactive form was recorded in lungs (32 µg / g in the interval of 5–30 minutes after introduction), liver (20.8 µg / g in the interval of 4–24 hours after introduction) and spleen (28 µg / g 4 hours after introduction). At the same time, by the end of the observation period (7 days after administration), trace amounts of the PS photoactive form were still detected in the liver and the spleen at a calculated concentration of 0.5‑1 µg / g. The PS accumulated the least in muscles and skin. The ﬂuorescent signal from the PS accumulated in skin was detectable almost immediately, and its concentration remained at the same level (1.2‑1.5 µg / g) for up to 3 days of observation. In the muscles, the concentration of the PS reached 1.5 µg / g 15 minutes after administration, and then gradually decreased until 0.25 µg / g at 24 hours. Data on the pharmacokinetics of PS in blood, basic organs and tissues of animals were obtained, pharmacokinetic parameters were calculated. 7 days after the administration, the PS concentration in the skin and muscles was below the detection limit. The studies confrmed that PEGylation of the PS liposomal form slows down the process of its capture by reticulo‑endothelial system. It was shown that the PS circulates in blood and organs of mice for a long time and it completely distributes only when 4 hours pass after administration.
PURWARUPA APLIKASI BERGERAK UNTUK MENDUKUNG EFEKTIFITAS PEMBELAJARAN MATEMATIKA SEKOLAH MENENGAH PERTAMA
Authors: Widianta Moh. Munih Dian , Riskiawan Hendra Yufit , Munawaroh Tutut Hidayati
Published: January 2019

Perkembangan teknologi telepon selular semakin pesat, ini dapat dibuktikan dengan banyaknya teknologi telepon seluler yang dikembangkan untuk memenuhi kebutuhan masyarakat. Teknologi yang sangat dominan dalam pertumbuhan telepon seluler adalah sistem operasi Android. Sistem ini memungkinkan pengembang aplikasi untuk mengembangkan aplikasi yang dibuat. Android merupakan platform mobile pertama yang memiliki fitur relatif lengkap, terbuka dan bebas. Lengkap dalam penyediaan peralatan dalam membangun software, terbuka dalam kebebasan mengembangkan aplikasi, bebas yang berarti dapat didistribusikan dan diperdagangkan dalam bentuk apapun.Pesatnya perkembangan teknologi tersebut dan banyaknya pengguna telepon seluler utamanya dikalangan pelajar, sangat potensial untuk dimanfaatkan berbagai kebutuhan yang mendukung pembelajaran. Untuk menjawab kebutuhan tersebut, melalui penelitian ini dibangun purwarupa aplikasi pembelajaran matematika untuk siswa SMP berbasis android yang didalamnya terdapat materi beserta soal latihan yang ditampilkan secara menarik dan interaktif agar dapatÂ  membantu guru untuk memantapkan pembelajaran yang telah diperoleh di kelas. Selain itu aplikasi bergerak ini diharapkan dapat membantu siswa agarÂ  lebihÂ  mengertiÂ  danÂ  memahami serta dapat menumbuhkan Â rasaÂ  ketertarikanÂ  siswaÂ  terhadapÂ  mataÂ  pelajaranÂ  matematika.Â  Selain tentunya ikut membantu perkembangan pendidikan di Indonesia.