bluuebunny/crossref_metadata_2025 huggingface dataset:
Construction of a Cuproptosis-Related Signature for Predicting Prognosis and Immune Response in Clear Cell Renal Cell Carcinoma
Authors: Cui Yankang , Zhang Jing , Shen Tianyi , Jiang Aiming , Xu Feng , Fang Bo , Shi Changjie , Yi Xiaoming , Lv Huichen , Wang Suchun , He Haowei , Tang Hao , Ge Jingping , Qu Le
Published: August 2022

Background
Cuproptosis is a new form of programmed cell death which induced by copper. The signature of cuproptosis related lncRNAs and mRNAs (CRLM) has not been reported before in clear cell renal cell carcinoma.
Methods
The RNA-seq, clinical data, and single nucleotide variants (SNV) data of clear cell renal cell carcinoma (ccRCC) were obtained from the Cancer Genome Atlas (TCGA). Cuproptosis related long non-coding RNAs (lncRNAs) were identified via Pearson’s test. Cox regression and Least Absolute Shrinkage and Selection Operator (LASSO) regression analyses were used to further screen prognosis related lncRNAs and mRNAs for signature construction. Cases were then randomly divided into training and testing set groups at ratio 1:1 to validate the cuproptosis signature. Kaplan–Meier survival analysis, receiver operating characteristic (ROC) curve analysis, nomogram, principal components analysis (PCA), gene set enrichment analyses (GSEA), mutation landscape, and therapies response were subsequently conducted with R or perl algorithms. A Japanese ccRCC cohort (n = 98) was used to validate this signature.
Results
A total of 245 lncRNAs were identified as cuproptosis related. Three of them (AL731577.2, LINC00460, AL133215.2) and cuproptosis related mRNA DBT were finally incorporated into the signature construction. High-risk group patients suffered from lower survival rate. The area under curve (AUC) of the novel signature for 1-, 3-, 5-year survival rates was 0.731, 0.718, 0.745, respectively. The concordance index (C-index) was 0.692. The Japanese cohort showed a good consistence with the results derived from the TCGA dataset. Tumor mutation burden (TMB) was also found to be a risking factor for ccRCC patients. Immune related Gene ontology terms were significantly enriched in high-risk patients. Besides, low-risk patients may be more sensitive to immune check inhibitors (ICIs), Sunitinib, and Pazopanib. High-risk patients may be more sensitive to Sorafenib.
Conclusion
The cuproptosis related signature is a promising and potential prognostic tool in predicting the survival of patients with ccRCC. It could contribute to precise and individualized ccRCC treatment.
Glycolysis induced by METTL14-related m6A methylation is essential for macrophage function and tumor progression in cervical cancer
Authors: Wang Bingyu , Jiao Xinlin , Zhang Teng , Liu Qingqing , Ye Jinwen , Feng Yuan , Cui Baoxia
Published: August 2022

Cervical cancer is one of the most common tumors of women’s diseases. N6-methyladenosine (m6A) is an abundant RNA modification of mammalian mRNAs and plays a vital role in many diseases, especially tumors. In this study, we aimed to investigate the roles of m6A on macrophage function and tumor progression in cervical cancer. We measured the levels of m6A expression in cervical cancer tissues, and revealed biological functions of METTL14 (Methyltransferase14, N6-Adenosine-Methyltransferase Subunit) on tumor-associated macrophages (TAMs) and PD-1 expression. We found the METTL14-related methylation of m6A in cervical cancer was correlated with infiltration of TAMs, polarization status of infiltrated TAMs, and survival outcomes of cervical cancer patients. Mechanistically, lactate produced by tumor glycolysis in the acidic immunosuppressive tumor microenvironment (TME) has an important role as a proinflammatory and immunosuppressive mediator in this program. METTL14-related methylation of m6A may play a predictive role in the polarization and PD-1 expression of macrophages in TME. The study intends to reveal the effect of m6A on the immune microenvironment and macrophage differentiation of cervical cancer, which could be a viable therapeutic target for the treatment of advanced human cancers.
The lysosome membrane protein, Sidt2: A novel insulin granule membrane protein regulates β cell dedifferentiation by a new pathway involving insulin secretion
Authors: Gao Jialin , Gu Jing , Qi Meng-xiang , Hu Xing , Song Ying-ying , Liu Hai-jun , Zhang Ya-ting , Wu Wen-xiu , Wu Ya-jun , Xu Jia-hao , Wang Jun-hao , Li Jing-rong , Liu Miao-miao , Pei Wen-jun , Zhang Yao , Wang Li-zhuo
Published: August 2022

β-cell dedifferentiation is important in the pathogenesis of type 2 diabetes, and the relationship between lysosome membrane proteins and pancreatic β-cell dedifferentiation is still unknown. Sidt2 is a lysosomal membrane protein identified in our previous study. After Sidt2 elimination, mice exhibited a diabetic phenotype. In the present study, we found that Sidt2 also can be considered a new insulin granule membrane protein. Sidt2 deficiency resulted in islet dysfunction and inhibited insulin secretion. The absence of Sidt2 also led to increased β cell dedifferentiation in mice. Further experiments showed that defects in insulin secretion caused dedifferentiation in the absence of Sid2. In summary, our study has found a new dedifferentiation regulatory mechanism mediated by a lysosomal membrane protein. This new secretory regulation pathway will enrich our understanding of the regulatory mechanisms involved in β cell dedifferentiation and provide new insights into the pathogenesis of diabetes.
Understanding of Bacterial Lignin Extracellular Degradation Mechanisms by Pseudomonas putida KT2440 via Secretomic Analysis
Authors: Xu Zhangyang , Peng Bo , Kitata Reta Birhanu , Nicora Carrie D. , Weitz Karl K. , Pu Yunqiao , Shi Tujin , Cort John R. , Ragauskas Arthur J. , Yang Bin
Published: August 2022

Background: Bacterial lignin degradation is believed to be primarily achieved by a secreted enzyme system. Effects of such extracellular enzyme systems on lignin structural changes and degradation pathways are still not clearly understood, which remains as a bottleneck in the bacterial lignin bioconversion process. Results: This study investigated lignin degradation using an isolated secretome secreted by Pseudomonas putida KT2440 that grew on glucose as the only carbon source. Enzyme assays revealed that the secretome harbored oxidase and peroxidase/Mn2+-peroxidase capacity and reached the highest activity at 120 h of the fermentation time. The degradation rate of alkali lignin was found to be only 8.1% by oxidases, but increased to 14.5% with the activation of peroxidase/Mn2+-peroxidase. Gas chromatography-mass spectrometry (GC-MS) and two-dimensional 1H-13C heteronuclear single-quantum coherence (HSQC) NMR analysis revealed that the oxidases exhibited strong C-C bond (β-β, β-5, and β-1) cleavage. The activation of peroxidases enhanced lignin degradation by stimulating C-O bond (β-O-4) cleavage, resulting in increased yields of aromatic monomers and dimers. Further mass spectrometry-based quantitative proteomics measurements comprehensively identified different groups of enzymes particularly oxidoreductases in P. putida secretome, including reductases, peroxidases, monooxygenases, dioxygenases, oxidases, and dehydrogenases, potentially contributed to the lignin degradation process. Conclusions: Overall, we discovered that bacterial extracellular degradation of alkali lignin to vanillin, vanillic acid, and other lignin derived-aromatics involved a series of oxidative cleavage, catalyzed by active DyP-type peroxidase, multicopper oxidase, and other accessory enzymes. These resutls will guide further metabolic engineering design to improve the efficiency of lignin bioconversion.
Design of an Unmanned Aerial Vehicle for Emergency Situations
Authors: Khan Nafiz Ahmed , Jahan Nusrat , Rayhan Saiaf Bin , Salam Md. Abdus
Published: August 2022

Current research deals with the design, constructions, and prospective applications of a radio-controlled Unmanned Aerial Vehicle (UAV) which was manufactured for the TÜBİTAK UAV TURKEY competition. The motivation behind this research was for possible applications in emergencies (fire, natural disaster, or medical emergencies) due to its remote controllability, maneuverability, and payload carrying capacity. In the conceptual design phase, the individual mission requirements were converted to design requirements, and the UAV's empty weight was estimated after that. Power and wing loading were determined based on the mission profile for the preliminary design. The X-Foil code was then used to compute the aerodynamic efficiency of the airfoil section, after which the wing, fuselage, and empennage were designed. For the detailed design, the structural analysis along the wing span and aircraft performance of the each mission was carried out. Following that, a stability analysis (longitudinal, lateral, and directional) was performed to ensure the UAV's overall stability in the event of any disturbances, and the wing's aerodynamic capabilities were assessed using computational fluid dynamics. Finally, the weight of each component and its corresponding center of gravity (C.G.) were calculated to determine the UAV's most forward and aft centers of gravity.
Temperature-Dependent Enhanced Speciation in Ecosystems with Conserved Symmetries
Authors: Bernido Christopher C.
Published: August 2022

The impact of climate change on biodiversity needs to be understood from a multidisciplinary approach. Using an analytical framework, we investigate the species response to rising temperatures. Common traits and characteristics among species that allow classification at different taxonomic levels imply an underlying symmetry that gives rise to invariances behind the biodiversity observed in nature. Changing temperatures that go beyond a critical limit break this underlying symmetry which could lead to enhanced speciation.
Inhibition of Copper Corrosion in Acid Medium by Imidazole-Based Compounds: Electrochemical and Molecular Approaches
Authors: Costa Stefane , Almeida-Neto Francisco , Marinho Emmanuel , Campos Othon , Correia Adriana , de Lima-Neto Pedro
Published: August 2022

Chemically modified imidazole molecules: 4-(1H-imidazol-1-yl)aniline, 4-(1H-imidazol1-yl)benzaldehyde, 4-(1H-imidazol-1-yl)phenol and (4-(1H-imidazol-1-yl)phenyl)methanol were investigated as inhibitors of the copper (Cu0) corrosion in 0.5 mol L-1 H2SO4 medium. The electrochemical corrosion data were obtained by monitoring open circuit potential, linear potentiodynamic polarization and electrochemical impedance spectroscopy techniques, while the computational density functional theory (DFT) method was applied to correlate the electronic properties of the molecules with corrosion inhibition efficiencies. All molecules had inhibited the Cu corrosion, and the inhibition values lied between 80 and 94%. A good correlation between the inhibition efficiencies values and Gibbs adsorption energy was found, showing that the more negative Gibbs energy, better interaction between the corrosion inhibitor with the Cu0 surface, diminishing its corrosion in 0.5 mol L-1 H2SO4 medium. The DFT calculations showed significative differences in electronic and reactivity properties of imidazole and other molecules. The higher corrosion inhibition of imidazole derivates could be explained by electrophilic characteristic of these molecules, since there are empty molecular orbitals spread over mainly in benzene rings that make a metal-ligand charge transfer, receiving electronic density from the copper surface by backbonding, according to the electronic Fukui functions and the potential charge distribution considering the map of electrostatic potential.
EVALUATION OF THE USE OF THE VIDEO CONFERENCE PLATFORM ON ZOOM BASED ON THE NIELSEN MODEL
Authors: Zuhairi Naufal Azzam
Published: August 2022

Video Conference is a platform that can make it easier to communicate or meet face to face virtually. Video conferencing platform users have tended to increase since the COVID-19 pandemic caused teaching and learning activities to be carried out from home or online. This study aims to evaluate and determine the usability of the video conferencing platform on Zoom based on the Nielson Model which is mapped on the framework pieces. This study uses respondents who are students from Mts Raudhatul Muttaqien, Purwomartani, Kalasan, Sleman, Yogyakarta which produces 60 respondents with an average response value of 85% (very good or very like) on the Zoom Meeting platform.Keywords: Usability, Nielsen, Video Conference Zoom.
PERBANDINGAN METODE ALGORITMA C4.5 DAN NAÏVE BAYES UNTUK MEMPREDIKSI KELULUSAN MAHASISWA
Authors: Rahmayanti Aulia , Rusdiana Lili , Suratno Suratno
Published: August 2022

This study was conducted to compare the accuracy of two algorithm methods, namely the C4.5 algorithm and Naïve Bayes algorithm on a number of datasets. The sources of datasets used are student data of the Informatics Engineering Study Program (STMIK Palangkaraya) where each dataset has a different amount of data (instances) and number of attributes. Based on the results of the comparison study of the C4.5 and Naïve Bayes Algorithm for Predicting the On-time Graduation of STMIK Palangkaraya Students, the results obtained from the accuracy of the two algorithms show that the accuracy of the C4.5 Algorithm is 90% better than the Naïve Bayes algorithm, which is only 85%.  The C4.5 algorithm also gives values on recall and precision of 92% and 94% better than the Naïve Bayes algorithm with values of 86% and 93%, respectively.
nnovative Potential of the Kemerovo Region: Current State and Development Prospects
Authors: Podzorova Galina A , Artemenko Anna , Gryaznova Natalya , Komarcheva Oxsana
Published: August 2022

The effective innovation activity in the region depends on the state and development of its innovative potential. The authors used theoretical, statistical, comparative, and analytical methods to describe the concept of innovative potential, evaluate its current state in the Kemerovo Region, and identify the promising areas for its development. The article introduces a comparative analysis of innovative and entrepreneurial activity in the Kemerovo Region in 2016–2020. The methodology developed by the Higher School of Economics of the National Research University made it possible to compare the indicators of innovative development in different regions of the Siberian Federal District. The analysis included the dynamics of the factors in order to calculate the indicators of innovative development and rank the regions. In terms of innovation activity, the Kemerovo Region appeared to be inferior to such leading regions of the Siberian Federal District as Tomsk, Novosibirsk, Irkutsk, and Krasnoyarsk. However, the region has good potential opportunities for innovative development. The authors recommend several promising directions that could develop the innovative potential of the region, create competitive advantages, attract additional investment, develop its digitalization potential, and increase its participation in the federal innovative, scientific, and technical policy, as well as to make it attractive for young people.
Legionella colonisation in hot water systems in care homes from two Danish municipalities
Authors: Nielsen Niss Skov , Uldum Søren Anker
Published: August 2022

Legionnaires' disease is a serious health risk among the elderly. Water systems in care homes are therefore of particular interest. We investigated the levels of culturable Legionella in the hot water systems in care homes in two Danish municipalities. Two hundred and sixty-eight water samples from 98 care homes were evaluated. Contents of culturable Legionella counts were calculated, and correlations between temperature and colony-forming units (CFU/L) were analysed. Seventy-seven and 81%, respectively, of the care homes were colonised with Legionella in the two municipalities. Most care homes had less than 1,000 CFU/L, but 13 and 16% had more than 10,000 CFU/L. When including first flush samples, 27% of the care homes in Municipality 1 had Legionella levels above 10,000 CFU/L. Temperatures of ≥50 °C in Municipality 1 and ≥55 °C in Municipality 2 correlated with low levels of Legionella. The content of Legionella colonies was significantly higher in care homes in Municipality 1. However, a significantly higher proportion of taps in Municipality 2 had Legionella colonies. In conclusion, temperatures should be raised to 55 °C to avoid high Legionella levels. Test procedures should be evaluated, and the regular use of taps and routine testing for Legionella should be taken into consideration.
Efficient use of liquid digestate in microalgae cultivation for high biomass production and nutrient recovery
Authors: Akkaya Ebru , Can-Güven Emine
Published: August 2022

In this study, different pre-treatment methods were applied to liquid digestate (LD) for the growth of the mixed microalgal culture. In addition, nutrient removal in the LD was investigated. Dilution, filtration, and centrifugation were applied as pre-treatment methods. Microalgal growth was evaluated as dry weight (DW) and nutrient removal was investigated with the analysis of ammonium (NH4+-N) and phosphate (PO4−3-P). Microalgal DW constantly increased throughout the experiment and reached the maximum values of 4.24, 4.02, and 1.47 g/L in centrifuged, diluted, and filtered medium, respectively. Maximum NH4+ (97.7%) and PO4−3 (50.4%) removal efficiency was observed in the centrifuged LD. Based on the results of this study, the optimum growth medium for microalgal growth was centrifuged LD but this culture can be cultivated in diluted LD up to 40-fold. Results also showed that using LD for microalgae production is a suitable application for both nutrient supply for microalgal growth and nutrient recovery from LD.
Activated persulfate by iron-carbon micro electrolysis used for refractory organics degradation in wastewater: a review
Authors: Chen Yu , Gao Yanjiao , Liu Tingting , Zhang Zhao , Li Weishi
Published: August 2022

With the rapid economic development, the discharge of industrial wastewater and municipal wastewater containing many refractory organic pollutants is increasing, so there is an urgent need for processes that can treat refractory organics in wastewater. Iron-carbon micro electrolysis and advanced oxidation based on persulfate radicals (SO4−·) have received much attention in the field of organic wastewater treatment. Iron-carbon micro electrolysis activated persulfate (Fe-C/PS) treatment of wastewater is characterized by high oxidation efficiency and no secondary pollution. This paper reviews the mechanism and process of Fe-C/PS, degradation of organics in different wastewater, and the influencing factors. In addition, the degradation efficiency and optimal reaction conditions (oxidant concentration, catalyst concentration, iron-carbon material, and pH) of Fe-C/PS in the treatment of refractory organics in wastewater are summarized. Moreover, the important factors affecting the degradation of organics by Fe-C/PS are presented. Finally, we analyzed the challenges and the prospects for the future of Fe-C/PS in application, and concluded that the main future directions are to improve the degradation efficiency and cost by synthesizing stable and efficient catalysts, optimizing process parameters, and expanding the application scope.
Prevalence, clinical and epidemiological features of feline hyperthyroidism at a veterinary teaching hospital in Brazil: a retrospective study
Authors: Taranti Leila , Haipek Kátia , Furtado Priscila Viau , Oliveira Cláudio Alvarenga de , Filgueira Kilder Dantas , Sellera Fábio Parra , Gargano Ronaldo Gomes , Reche-Júnior Archivaldo
Published: August 2022

The hyperthyroidism is the most frequently endocrinopathy in cats. The increasing number of diagnoses over time is due to the greater familiarity with the disease and the development of increasingly sensitive diagnostic tools available. This study aimed to retrospectively evaluate the prevalence, clinical characteristics and risk factors of hyperthyroidism in cats admitted at one of the largest veterinary teaching hospital in Brazil. Between 2002 and 2007, 234 cats were admitted to the veterinary teaching hospital of the University of São Paulo, Brazil. Total thyroxine (T4t) serum concentration was measured from all cats. Also analyzed the medical charts of cats. Of the 234 cats, 26 (11.1%) were considered hyperthyroid (T4t ≥3.8 μg/dL). Of hese 26 cats, only two (7.7%) were initially diagnosed as hyperthyroid. The age of cats ranged from 6 to 27 years old (13.1 ± 4.5 years). Twelve patients (46.2%) were female and 14 (53.8%) were male. Eight (30.8%) cats were Siamese, while the others were mixed breed (69.2%). Dry food was the most common food type consumed by cats. There was a high prevalence of hyperthyroid cats with concomitant chronic kidney disease (CKD). This study sheds light on the importance of routinely monitoring feline hyperthyroidism and brings epidemiological and clinical data of this endocrinopathy in cats from one of the largest veterinary teaching hospitals in the country.
Isolation of Escherichia coli and Staphylococcus aureusin raw milk from refrigeration tanks: identification and antimicrobial resistance profiles
Authors: Almeida Patrícia Veiga de , Cunha Neto Adelino da , Anjos Tais Ramalho dos , Dias Naudia da Silva , Andrade Kethin Raianne Nunes Calixto de , Nascimento Jade Gabriela Oliveira , Figueiredo Eduardo Eustáquio de Souza , Carvalho Ricardo César Tavares
Published: August 2022

Escherichia coli and Staphylococcus aureus in milk cooling tank reflects a hygienic deficit in animal management, production environment, and milk obtainment. With implications for public health as agents of infection and food poisoning, and the presence of antimicrobial-resistant strains. Therefore, were investigated in cooling tanks with high counts of somatic cells and total bacteria in milk. Microorganisms, in which a profile of resistance to antimicrobials was investigated, and whether there was a similarity in this profile between the strains of the eight dairy properties.Therefore, eighty-eight samples were obtained, and inoculated on Compact Dry® plates. Of this total, 27.27% (24/88) samples tested positive for E. coli and 56.81% (50/88) for S. aureus. Among 24 E. coli strains subjected to disk-diffusion antibiograms, 70.83% were resistant to rifampicin, 50% to ampicillin and 41.67% to cefoxitin and erythromycin, while of the 51 S. aureus strains, 94.32% expressed resistance to azetroanam, 86.27% to ampicillin and nalidixic acid, 76.47% to rifampicin and 47.06 % to erythromycin and cefoxitin. A criterion of resistance to over three antibiotics was observed for 8.33% (2/24) of the isolated E. coli strains and 17.65% (9/51) of the S. aureus strains, characterizing them as multidrug resistant (MDR) strains. Resistance phenotypes displayed high similarity between properties F5 and F6 for S. aureus, and properties F6 and F8 for E. coli when applying the Jaccard index. The presence of these antibiotic-resistant pathogenic microorganisms indicate flaws in milk production handling and sanitary conditions, representing risk to milk consumers.
Personalizm Karola Wojtyły a problemy etyczne związane z komórkami macierzystymi
Authors: Burdyn Mateusz
Published: August 2022

W pracy omówiono zagadnienie wymiaru etycznego pozyskiwania i wykorzystywania komórek macierzystych w oparciu o filozofię personalistyczną wypracowaną przez Karola Wojtyłę, na podstawie jego tekstów sprzed wyboru na biskupa Rzymu. Celem pracy było przedstawienie argumentów etycznych i medycznych orzekających o wykorzystywaniu indukowanych pluripotentnych komórek macierzystych w terapii. Miało to wykazać brak konieczności wykorzystywania embrionalnych komórek macierzystych oraz niemoralność tego procederu. Zastosowano metodę analizy krytycznej.
A Comparison Between Clinical Guidelines and Real-World Treatment Data in Examining the Use of Session Summaries: Retrospective Study
Authors: Sadeh-Sharvit Shiri , Rego Simon A , Jefroykin Samuel , Peretz Gal , Kupershmidt Tomer
Published: August 2022

Background

Although behavioral interventions have been found to be efficacious and effective in randomized clinical trials for most mental illnesses, the quality and efficacy of mental health care delivery remains inadequate in real-world settings, partly owing to suboptimal treatment fidelity. This “therapist drift” is an ongoing issue that ultimately reduces the effectiveness of treatments; however, until recently, there have been limited opportunities to assess adherence beyond large randomized controlled trials.

Objective

This study explored therapists’ use of a standard component that is pertinent across most behavioral treatments—prompting clients to summarize their treatment session as a means for consolidating and augmenting their understanding of the session and the treatment plan.

Methods

The data set for this study comprised 17,607 behavioral treatment sessions administered by 322 therapists to 3519 patients in 37 behavioral health care programs across the United States. Sessions were captured by a therapy-specific artificial intelligence (AI) platform, and an automatic speech recognition system transcribed the treatment meeting and separated the data to the therapist and client utterances. A search for possible session summary prompts was then conducted, with 2 psychologists validating the text that emerged.

Results

We found that despite clinical recommendations, only 54 (0.30%) sessions included a summary. Exploratory analyses indicated that session summaries mostly addressed relationships (n=27), work (n=20), change (n=6), and alcohol (n=5). Sessions with meeting summaries were also characterized by greater therapist interventions and included greater use of validation, complex reflections, and proactive problem-solving techniques.

Conclusions

To the best of our knowledge, this is the first study to assess a large, diverse data set of real-world treatment practices. Our findings provide evidence that fidelity with the core components of empirically designed psychological interventions is a challenge in real-world settings. The results of this study can inform the development of machine learning and AI algorithms and offer nuanced, timely feedback to providers, thereby improving the delivery of evidence-based practices and quality of mental health care services and facilitating better clinical outcomes in real-world settings.
The Effect of Gender-Affirming Hormone Therapy on Measures of Kidney Function
Authors: Krupka Emily , Curtis Sarah , Ferguson Thomas , Whitlock Reid , Askin Nicole , Millar Adam C. , Dahl Marshall , Fung Raymond , Ahmed Sofia B. , Tangri Navdeep , Walsh Michael , Collister David
Published: August 2022

Background and objectives

Gender-affirming hormone therapy modifies body composition and lean muscle mass in transgender persons. We sought to characterize the change in serum creatinine, other kidney function biomarkers, and GFR in transgender persons initiating masculinizing and feminizing gender-affirming hormone therapy.

Design, setting, participants, & measurements

We searched PubMed, EMBASE, the Cochrane Library, and ClinicalTrials.gov from inception to September 16, 2020 for randomized controlled trials, observational studies, and case series that evaluated the change in serum creatinine, other kidney function biomarkers, and GFR before and after the initiation of gender-affirming hormone therapy in adult transgender persons. Two reviewers independently screened and abstracted data, and disagreements were resolved by a third reviewer. A random effects meta-analysis was performed to determine the change in outcomes over follow-up of 3, 6, and 12 months.

Results

Of the 4758 eligible studies, 26 met the inclusion criteria, including nine studies that recruited 488 transgender men and 593 women in which data were meta-analyzed. There was heterogeneity in study design, populations, gender-affirming hormone therapy routes, and dosing. At 12 months after initiating gender-affirming hormone therapy, serum creatinine increased by 0.15 mg/dl (95% confidence interval, 0.00 to 0.29) in 370 transgender men and decreased by −0.05 mg/dl (95% confidence interval, −0.16 to 0.05) in 361 transgender women. No study reported the effect of gender-affirming hormone therapy on albuminuria, proteinuria, cystatin C, or measured GFR.

Conclusions

Gender-affirming hormone therapy increases serum creatinine in transgender men and does not affect serum creatinine in transgender women. The effect on gender-affirming hormone therapy on other kidney function biomarkers and measured GFR is unknown.

Clinical Trial registry name and registration number:

Change in Kidney Function Biomarkers in Transgender Persons on Gender Affirmation Hormone Therapy–A Systematic Review and Meta-Analysis, CRD42020214248
Análisis factorial de las mediciones cefalométricas sagitales de las vías aéreas superiores
Authors: Luna Godoy Adrián , Cruz Chávez Luis , Rodríguez Anaya Ofelia , Montoya Guzmán Diana , Sánchez García Sergio , Ángeles Medina Fernando , Rodríguez Chávez Jacqueline , Cruz Hervert Luis Pablo
Published: August 2022

Existen diferentes medidas cefalométricas para evaluar las dimensiones de las vías aéreas superiores a partir del uso de la radiografía lateral de cráneo. Se desconoce qué características o factores de las vías aéreas son identificables y posibles de estudiar a partir de las mediciones disponibles y cuáles son las mediciones más útiles para dicho fin. Objetivo: Identificar los factores de las mediciones de las vías aéreas superiores y determinar su asociación a las dimensiones craneofaciales. Material y métodos: Estudio transversal. Analizamos las radiografías laterales y realizamos un análisis factorial principal para las mediciones de las vías respiratorias superiores: N-S-Ba, Ba-S-PNS, AD1, AD2, PTV a adenoides (DPTV) y Airway% (A%). Resultados: Analizamos 151 registros, sin tratamiento de ortodoncia previo ni síndrome craneofacial. Identificamos dos factores principales: el factor 1 (F1) incluye AD1, AD2, DPTV y A%, y el factor 2 (F2) incluye N-S-Ba y Ba-S-ENP. Conclusiones: F1 se relacionó con las dimensiones lineales y F2 con las características estructurales.
Tratamiento correctivo de protrusión dentoalveolar bimaxilar clase I moderada: distalización dentoalveolar bimaxilar con miniimplantes
Authors: Méndez Ordóñez Francisco Shamed , García García Gisel , Ruíz Díaz Roberto , Guzmán Valdivia Gómez Isaac
Published: August 2022

Existen diversas formas de tratar las clase I biprotrusivas y éstas van a estar directamente relacionadas con la severidad del caso. La forma más común de tratamiento incluye la extracción de los primeros premolares maxilares y mandibulares, así como la retracción del segmento anterior para disminuir la biprotrusión bimaxilar. Una nueva alternativa de tratamiento para este tipo de maloclusiones puede ser la distalización bimaxilar con el uso de miniimplantes, lo cual además de garantizarnos un máximo anclaje nos permitirá mover múltiples dientes en una sola dirección con movimientos controlados. Material y métodos: Se colocaron cuatro miniimplantes como anclaje máximo (dos infracigomáticos de 10 mm y dos en el shelf mandibular de 12 mm) para realizar una distalización bimaxilar, se colocaron brackets de autoligado pasivo y apoyados en cadenas elásticas se realizó la distalización en masa de ambas arcadas. Resultados: Los miniimplantes demostraron ser una alternativa eficiente para la corrección de una protrusión bimaxilar moderada, la distalización se realizó hasta conseguir una adecuada clase I molar y clase I canina en ambos lados, así como una sobremordida horizontal y vertical adecuada, los cambios estéticos faciales fueron una disminución de la biproquelia. Conclusiones: El tratamiento de la clase I biprotrusiva dependerá de la severidad del caso, los miniimplantes demuestran ser una opción interesante para el tratamiento de este tipo de maloclusiones.
Tratamiento ortodóncico-quirúrgico de una maloclusión clase III esquelética combinada con laterognasia
Authors: Martínez Hernández Eduardo Adrián , Vásquez Estrada Hugo Alberto , Hernández Carvallo José Ramón
Published: August 2022

Introducción: La maloclusión clase III esquelética es la falta de armonía de la posición entre el maxilar y la mandíbula en relación con su base de cráneo, afectando tanto la estética facial como la función masticatoria. La asimetría facial es una manifestación común en pacientes clase III, degradando la calidad del paciente. La mayoría de estos pacientes son candidatos a someterse a cirugía ortognática que brindará al paciente mejores resultados. Material y métodos: Se reporta caso de paciente masculino de 15 años de edad con maloclusión clase III esquelética, biotipo dolicofacial, perfi l recto, clase III molar y canina bilateral, mordida borde a borde en sector anterior y cúspide a cúspide en sector posterior. El tratamiento comprendió una etapa ortodóncica prequirúrgica, cirugía ortognática bimaxilar y una etapa postquirúrgica y de retención. Objetivos: Los objetivos del tratamiento fueron la corrección ortodóncica-quirúrgica en los tres planos del espacio, corregir laterognasia, otorgar estabilidad oclusal y estética facial, salud articular y periodontal. Resultados: Se logró una adecuada relación maxilo-mandibular, clase I molar y canina, corrección de laterognasia, coincidencia de líneas medias, estética facial además de estabilidad oclusal. Conclusión: Para obtener un resultado exitoso es necesario un diagnóstico adecuado así como una correcta planifi cación interdisciplinaria, ya que las asimetrías dentofaciales son un complejo problema, muchas veces imposible de corregir mediante ortodoncia únicamente.
Tratamiento ortodóncico quirúrgico, de la hipoplasia maxilar con maloclusión clase III con mordida cruzada bilateral. Reporte de caso
Authors: Liriano Martínez Bryant Omar , Gurrola Martínez Beatriz , Casasa Araujo Adán
Published: August 2022

Uno de los retos del ortodoncista es la exigencia de alcanzar una armonía estética partiendo de unas alteraciones dentoesqueléticas, las cuales son determinadas por una infi nita variabilidad individual en la estructura y espesor de los tejidos blandos. Se muestra el protocolo de atención de un paciente de 26 años, quien refi rió tener un grave problema de autoestima por su forma de comer y sonreír. En la valoración clínica y radiográfi ca fue diagnosticado con: hipoplasia del tercio medio, hiperdivergente, con presencia de maloclusión clase III molar canina bilateral, mordida cruzada anterior y posterior bilateral, con la línea media dental inferior desviada, pérdida ósea horizontal y vertical mandibular. Mediante el tratamiento quirúrgico se corrigió la hipoplasia maxilar con la osteotomía Le Fort I con un avance del maxilar de 8 mm y la giroversión de la línea media hacia la derecha. Para la corrección de la mordida cruzada anterior y posterior bilateral. Se procedió a la alineación y nivelación con elásticos cruzados. Se utilizó el arco overlay para la expansión dentoalveolar. Finalmente se detalló con brackets tipo Roth slot 0.022" x 0.028", con tubos bondeables colocados en los molares superiores 16 y 17 e inferiores 36 y 47. Se resolvió el problema de autoestima. El tiempo de tratamiento activo fue de tres años siete meses.
Diferencias cefalométricas entre la altura y divergencia faciales en pacientes de ortodoncia en una muestra mexicana
Authors: Silva Meza Roberto , Aguilar G Guillermo
Published: August 2022

Objetivo: Estimar por género las diferencias entre la altura y la divergencia faciales en pacientes evaluados para el tratamiento de ortodoncia de una muestra en población mexicana. Material y métodos: Se utilizó el método propuesto por Silva, observando su relación por género. Se estudió una muestra de 483 imágenes cefalométricas de pacientes, con edad entre ocho y 58 años de edad, 196 hombres y 287 mujeres. Resultados: De las 483 imágenes cefalométricas analizadas, se obtuvieron los siguientes resultados: la altura facial normal o neutra fue de 16.8%, la altura facial corta de 63.1% y la altura facial aumentada de 19.8%. El método cefalométrico utilizado relaciona directamente la divergencia facial con la mandibular, y la establece por la medida angular del ángulo goniaco. Este estudio mostró los siguientes resultados: normodivergente 53.6%, hipodivergente 22.3%, hiperdivergente 24%. En varones, el predominio fue de cara corta (48.7%) y con hipodivergencia mandibular (43.5%); mientras que en mujeres, la altura facial corta fue de 63.2% e hiperdivergencia 62%. Conclusiones: La altura y la divergencia faciales no siempre coinciden, la divergencia está asociada con la forma mandibular y no con la altura facial. La mayoría de la población incluida en este estudio tenía una altura facial corta, seguida de una cara larga y neutra.
Asociación del nivel de maloclusión, alteraciones dentomaxilofaciales y satisfacción del tratamiento ortodóncico en pacientes adolescentes de Ciudad Juárez, Chihuahua
Authors: Marín-Delgado Osvaldo , De León-Chacón Fabían , Espinosa-Cristóbal León Francisco , Donohué-Cornejo Alejandro , Cuevas-González Juan Carlos , García-Zamarrón Diana Juana , Constandse-Cortés Denise
Published: August 2022

Introducción: Las maloclusiones son una de las principales alteraciones que afectan la estética y función de los dientes. A pesar de las diversas evaluaciones para la identificación y distribución de las maloclusiones, no existen estudios que hayan determinado la distribución y asociaciones del nivel de maloclusión, alteraciones dentomaxilofaciales y el nivel de satisfacción de los tratamientos ortodóncicos a través del índice de estética dental de adolescentes que viven en la zona norte del país. Objetivos: Determinar el nivel de asociación de los niveles de maloclusión, alteraciones dentomaxilofaciales y el nivel de satisfacción del tratamiento de ortodoncia con el índice de estética dental en adolescentes de Ciudad Juárez, Chihuahua. Material y métodos: A través de un diseño transversal comparativo y un muestreo no probabilístico consecutivo, 150 adolescentes entre 12 y 18 años de edad fueron evaluados y entrevistados a través del índice de estética dental para la determinación de la severidad y distribución de las maloclusiones, alteraciones dentomaxilofaciales y el nivel de satisfacción del tratamiento ortodóncico. Resultados: La distribución de las maloclusiones (normal, definida, severa e incapacitante) disminuyeron frecuentemente con el avance de la severidad (35.3, 29.3, 28 y 7.3%, respectivamente). Las oclusiones normales aumentaron significativamente con el avance de la edad en ambos sexos (p < 0.05). Las alteraciones dentomaxilofaciales más frecuentes fueron el apiñamiento (90%), seguido de la irregularidad mandibular (80%), resalte maxilar (69.3%), irregularidad maxilar (68.6%), relación molar (67.3%), mientras que los menos frecuentes se encontraron a los espacios (23.3%), diastema (8%), dientes ausentes (6%), mordida abierta (4%) y overjet inferior (3.3%); todos distribuidos uniformemente en hombres y mujeres (p > 0.05). El nivel de maloclusión mostró asociaciones significativas con el nivel de satisfacción (p < 0.05). Conclusiones: El nivel de maloclusión dental de hombres y mujeres adolescentes podría influir en el comportamiento de satisfacción emocional relacionado con los tratamientos ortodóncicos, probablemente por la presencia de alteraciones morfológicas y anatómicas de dientes y maxilar.
Fundamento teórico epistémico del diagnóstico cráneo-cervico maxilofacial
Authors: Ramos Montiel Ronald Roossevelt
Published: August 2022

Desde los inicios del conocimiento, el hombre ha procurado acercarse a la realidad en la búsqueda de conocer, comprender, controlar y/o predecir el entorno que lo rodea; en tal suceso, el conocimiento puede adquirirse de manera vulgar (doxa) u opinión empírica como experiencias personales, científica trascendiendo los hechos de la realidad o de manera filosófica con la esencia y finalidades del mundo. En tal contexto, el análisis filosófico de la naturaleza del conocimiento relacionado con las características raciales y morfológicas de las poblaciones es un tema muy discutido desde tiempos inmemorables, así también, es uno de los temas sin resultados completamente definidos debido a la incesante búsqueda de la categorización y a la constante idealización de una clasificación de las características morfológicas que nos unen a la vez que nos diferencian.
Manejo ortodóncico de un paciente con maloclusión clase I con mordida cruzada anterior con crecimiento vertical y biprotrusión dental tratado sin extracciones
Authors: López Aguilera Melanie , Pérez Vázquez José Luis , Bernal Fulgencio Allan Jay , Villegas Echeverría Josué Elías , Barajas Ramírez David , Cerrillo Lara Daniel , García López Salvador
Published: August 2022

Este artículo informa sobre el diagnóstico de ortodoncia y la planificación del tratamiento de una paciente de 17 años con problemas estéticos y funcionales. Presentó maloclusión de Angle clase I, mordida cruzada anterior, doble protrusión incisiva e incompetencia labial, además de un perfil facial recto ligeramente cóncavo. Los objetivos fueron mantener el control vertical, mejorar la estética facial, eliminar el apiñamiento y corregir la mordida cruzada anterior. El tratamiento de ortodoncia no requirió extracciones. La mordida cruzada se corrigió mediante desgastes interproximales y fuerzas mecánicas a través de elásticos intermaxilares, lo que contribuyó a la alineación y nivelación de los dientes así como a mejorar el perfil facial de la paciente.
Análisis de elementos finitos de los efectos biomecánicos de micro-osteoperforaciones del hueso cortical ante fuerzas expansivas
Authors: Gómez Arango Juan Pablo , Peña Bustos Fabio Marcelo , Vega Arias David Alejandro , Gómez García Luis Felipe
Published: August 2022

Introducción: Las micro-osteoperforaciones (MOPs) son un procedimiento en el que se crean perforaciones en el hueso alrededor de los dientes para acelerar el movimiento dental durante el tratamiento de ortodoncia. Objetivo: Determinar los efectos biomecánicos de las MOPs del hueso cortical vestibular al aplicar una fuerza ortodóntica expansiva en un modelo de elementos finitos. Material y métodos: Se construyeron nueve modelos 3D de un premolar superior derecho: un modelo control; cuatro modelos para evaluar el efecto del número de perforaciones, dos modelos para evaluar el efecto de la profundidad de la perforación y dos modelos para evaluar el efecto del ancho de la perforación. Para establecer una comparación entre los modelos, se les aplicó una carga simulada de 2.6 Newton para imponerle un movimiento expansivo (0.20 mm) dirección vestibular, tomando en cuenta los patrones de esfuerzo y deformación unitaria en el hueso alveolar. Resultados: El modelo de elementos finitos evidenció que en las simulaciones con 4 y 9 MOPs se observó una tendencia creciente en el aumento de las microdeformaciones al aumentar el diámetro y la profundidad de las MOPs a 1 mm en siete de los ocho modelos. El modelo de cuatro MOPs con diámetro de 0.5 mm y profundidad de 1 mm se observó una disminución de las microdeformaciones. Conclusiones: La construcción de un modelo básico de elementos finitos de un segundo premolar superior evidenció que la utilización de las MOPs produce un aumento de las microdeformaciones óseas que promueven el proceso de remodelación ósea en las zonas de microtrauma.
A Comprehensive Study of Cardon Shaft Using Modal Analysis
Authors: Vahora Atik , Barot Hitanshiben , Barot Jaymin , Dobariya Darshak
Published: August 2022

Abstract: A rear-wheel-drive vehicle's Cardan shaft, a rotating shaft that transfers power from the engine to the differential gear, must work via continually shifting angles between the gearbox and axle. Due to the constant rotation, there is significant vibration on it. Due to this issue, the shaft frequently bends or deforms. Vibration in the Cardan shaft is a significant issue. In the present work, three distinct geometries—circular cut, rectangular cut, and no-cut—were modelled using SolidWorks software. Modal analysis was then carried out to obtain the deformation and natural frequency of all the CAD models for comparison. In the current investigation, the rectangular cut model, which produces the least deformation and natural frequency, was designated as the superior model.
Data Prediction and Analysis of Covid-19 Using Epidemic Models
Authors: Hemalatha C , Sreerambabu Dr. J. , Kalidasan S.
Published: August 2022

Abstract: Coronavirus scourge is manifested because the general fortune quandary of planetary stew by the planet Health Organization within the second multi day stretch of March 2020.This illness starts from China on December 2019 has simply caused destruction over the world, as well as Bharat. The initial case in quite an whereas was accounted on twenty third Gregorian calendar month 2020, with the cases crossing nearly 6000 on the day, paper was composed. Complete isolation of the country for twenty one days and fast disengagement of contaminated cases square measure the energetic advances took by the specialists during this work, Indian Covid dataset is taken for the Analysis and Prediction. 2 epidemic models name SIR and SEIR square measure accustomed analyse the dataset. Introductory clarification of each models square measure mentioned. Comparison of each the models were additionally carried and SEIR model is acting higher prediction than the SIR for our dataset
Factors Influencing Motivation in Online Arabic Learning of Indonesian Older Man
Authors: Mubarak Mahfuz Rizqi , Audina Noor Amalina , Wahdah Nurul , Hamidah Hamidah , Ilmiani Aulia Mustika
Published: August 2022

Changes in the offline learning system to online learning have an effect on the demotivation of students to learn. However, this fact does not affect an elderly Indonesian male. This study aims to explore motivational factors for these elderly men in participating in an online Arabic learning program organized by an informal institution in Indonesia. A narrative research design was used in this study. The data was extracted through in-depth interviews. The results showed that there were several factors that influenced the motivation to learn Arabic online from elderly men, namely: Motivation to understand Al-Qur'an, motivation from friends, and presentation of interesting Arabic material. These findings suggest further research on the motivation to learn Arabic online by involving elderly participants of various genders.
Teacher’s Challenges in Implementing HOTS in Learning Arabic During Covid-19 Pandemic
Authors: Ritonga Apri Wardana , Wargadinata Wildana , Hasan Nur , Ahmad Bakri Mohammad Bkheet
Published: August 2022

HOTS-based Arabic learning in the Covid-19 pandemic era experienced complex problems because the learning process carried out online had an impact on the implementation of HOTS which was not optimal. This research encourages the disclosure of the challenges faced by teachers when implementing HOTS in learning Arabic in the era of the Covid-19 pandemic. This research used a qualitative approach with the case study method in Islamic senior high school (MAN) 3 Padang Panjang West Sumatera, Indonesia. Collecting data was through an in-depth review of observations, interviews, and documents. Meanwhile, the data analysis technique was based on Miles and Huberman's theory by reducing data, presenting data, and concluding field findings. The data obtained were validated with data triangulation techniques and data sources. This study shows that the challenges faced by teachers stem from three main factors, namely; a) from the students' lack of Arabic language skills and uneven internet connection problems in the areas where students live; b) from the teachers' low understanding of the HOTS concept and its application in learning Arabic and; c) from school rules that have not set HOTS standards as a reference in learning. The test of the effectiveness of the application of HOTS skills in Arabic learning needs to be done through an online learning system.