bluuebunny/crossref_metadata_2025 huggingface dataset:
An Analysis of Structure-function Co-relation between GLI Oncoprotein and HLA Immune-gene Transcriptional Regulation through Molecular Docking
Authors: Majumder Durjoy
Published: August 2021

Background:

GLI proteins play a significant role in the transduction of the Hedgehog (Hh) signaling pathway. A variety of human cancers, including the brain, gastrointestinal, lung, breast, and prostate cancers, demonstrate inappropriate activation of this pathway. GLI helps in proliferation and has an inhibitory role in the differentiation of hematopoietic stem cells. Malignancies may have a defect in differentiation. Different types of malignancies and undifferentiated cells have a low level of HLA expression on their cell surface.

Objective:

Human Leukocytic Antigen (HLA) downregulation is frequently observed in cancer cells. This work is aimed to hypothesize whether this downregulation of HLA molecules is GLI oncoprotein mediated or not. To understand the roles of different types of GLI oncoproteins on different classes of HLA transcriptional machinery was carried out through structure-based modeling and molecular docking studies.

Methods:

To investigate the role of GLI in HLA expression /downregulation is Hh-GLI mediated or not, molecular docking based computational interaction studies were performed between different GLI proteins (GLI1, GLI2, and GLI3) with TATA box binding protein (TBP) and compare the binding efficiencies of different HLA gene (both HLA class I and –II) regulating transcription factors (RelA, RFX5, RFXAP, RFXANK, CIITA, CREB1, and their combinations) with TBP. Due to unavailability of 3D protein structures of GLI2 and cyclin D2 (a natural ligand of GLI1) were modelled followed by structural validation by Ramachandran plot analysis.

Results:

GLI proteins especially, GLI1 and GLI2, have almost similar binding energy of RFX5-RFXANK- RFXAP and CIITA multi-protein complex to TBP but has lower binding energy between RelA to TBP.

Conclusion:

This study suggests that HLA class I may not be downregulated by GLI; however, over-expression of GLI1 is may be responsible for HLA class II downregulation. Thus this protein may be responsible for the maintenance of the undifferentiated state of malignant cells. This study also suggests the implicative role of GLI1 in the early definitive stage of hematopoiesis.
High-output Cardiac Failure: A Forgotten Phenotype in Clinical Practice
Authors: de Ávila Diane Xavier , Villacorta Humberto , de Andrade Martins Wolney , Mesquita Evandro Tinoco
Published: August 2021

Introduction:

The knowledge on High-Output Cardiac Failure (HOCF) has greatly improved
in the last two decades. One of the advances was the identification of a new phenotype of
HOCF, characterized by the absence of ventricular dilation, already associated with liver disease,
Arteriovenous Fistulas (AVF), lung disease, myelodysplastic syndromes, and obesity. However, it
has been noted that any aetiology can present with one of the two phenotypes, depending on the
evolution.

Objective:

The study aims to describe, through an integrative review, the physiopathology and aetiologies
of HOCF and to discuss phenotypes associated with this condition.

Methods:

Revisions, guidelines, case-controls, cohort studies and clinical studies were searched in
MEDLINE and LILACS, using the connectives in the “cardiac output, high” database (MeSH
Terms) OR “high cardiac output” (All Fields).

Discussion:

Two distinct phenotypes are currently described in the HOCF, regardless of the aetiology:
1) one with enlarged cardiac chambers; and 2) with normal heart chambers. The mechanisms related
to HOCF are vasodilation, arteriovenous shunts that cause increased microvascular density,
Reduced Systemic Vascular Resistance (RSVR), and high metabolism. These mechanisms lead to
activation of the renin-angiotensin-aldosterone system, sodium and water retention, activation of
neprilysin, of the sodium-glucose-2 transporter, which promote interstitial fibrosis, ventricular remodeling
and a consequent increase in cardiac output >8L/min.

Conclusion:

Many aetiologies of HOCF have been described, and some of them are potentially curable.
Prompt recognition of this condition and proper treatment may lead to better outcomes.
Insights into Novel Coronavirus Disease 2019 (COVID-19):
Current Understanding, Research, and Therapeutic Updates
Authors: Sushma Dudala Sai , Jaiswal Varun , Kumar Arvind , Asha Syed , Pal Tarun
Published: August 2021

Background:

Humans can be infected with various coronaviruses that can cause serious
illness and death. One such pandemic strain of coronavirus was recently identified in December
2019, and it led to a devastating outbreak in Wuhan city of China. It is caused by severe
acute respiratory syndrome coronavirus 2 (SARS- CoV-2). It is highly contagious and
causes symptoms such as fever, cough, and shortness of breath.

Objective:

The objective of this review is to highlight the current understanding, research, and
therapeutic updates of the novel coronavirus disease 2019 (COVID-19).

Methods:

A thorough literature search was conducted for research papers and patents in the
context of COVID-19. All the related articles were extracted from various public repositories
such as Google Scholar, Pubmed, ScienceDirect (Elsevier), Springer, Web of Science, etc.

Results:

The present analysis revealed that the key areas of the inventions were vaccines and
diagnostic kits apart from developing the treatment of CoV. It was also observed that no specific
vaccine treatments were available for the treatment of 2019-nCov; therefore, developing
novel chemical or biological drugs and kits for early diagnosis, prevention, and disease management
is the primary governing topic among the patented inventions. The present study also
indicates potential research opportunities for the future, particularly to combat 2019-nCoV.
The current focus of the researches has turned towards developing four potential treatments,
including the development of candidate vaccines, development of novel potential drugs, repurposing
of existing drugs, and development of convalescent plasma therapy. The PCR based diagnosis
is the gold standard for the COVID-19 testing, but it requires resource time, expertise,
and high associated cost; hence researchers are also developing different diagnostic methods
for the COVID-19. Although vaccines are being developed by various companies and have
passed the pre-clinical stages but there still exists no guarantee for these to come into effect.
The current treatments that are being used for COVID-19 patients are not well established and
have shown limited success.

Conclusion:

The pandemic has challenged the medical, economic, and public health infrastructure
across the globe. There is an urgent need to explore all available and possible methods/
approaches to study this disease for drug and vaccine development at the earliest.
Research Progress Over Cu2O/n-type Semiconductor Composites in Photocatalysis
Authors: Zhang Yonghui , Shi Yatong , Xie Shiyu , Liu Mingming , Chen Junli , Gong Feilong
Published: August 2021

Photocatalysis is a feasible technology to solve energy shortage and environmental pollution
by using solar energy. Semiconductor photocatalysts with low cost, high stability and environmental
friendliness are demonstrated advantages for the production of solar fuel, CO2 reduction, and
degradation of pollutants. Among them, Cu2O presents numerous potential for photocatalysis because
of its narrow band gap and high activity under visible light. However, the rapid recombination of photoinduced
electron-hole pairs and the instability of Cu2O under light irradiation limit its photocatalytic
performance. In order to solve the above issues, researchers prefer to incorporate Cu2O with n-type
semiconductors to design p-n heterojunction composites, thus regulating the band structure, promoting
the separation and transfer of electrons and holes, and accelerating the redox reaction onto the surface.
In this manuscript, the preparation methods of Cu2O/n-type semiconductor composites such as hydrothermal
method, electrodeposition method, and in situ method are concluded, the photocatalytic applications
including CO2 reduction, hydrogen production, and degradation are presented, and the catalytic
mechanism like Z-scheme, p-n heterojunction, etc. are discussed, respectively. This review also
proposes that there are still challenges in broadening the photocatalytic application of Cu2O/n-type
semiconductor composites.
Simulación del consumo energético para la calefacción de un módulo de vivienda experimental ubicado a 4500 msnm
Authors: Ratache Rojas Pablo Ronel , Cabanillas Cesar Efraín Rivasplata , Horn Mutschler Manfred , Gómez León Mónica Marcela
Published: August 2021

En el presente trabajo se simula la demanda energética en un módulo de vivienda experimental construido en el poblado de Imata, Perú, ubicado a 4500 msnm. Previo a esto se desarrollaron las mediciones de temperatura y los cálculos energéticos necesarios para validar el modelo de simulación con el programa EnergyPlus. La predicción de la simulación indica que se necesita en un año 3,54 MWh, con un máximo diario de 11 kWh en julio y un mínimo diario de 8,4 kWh en diciembre (promedios mensuales), para mantener una temperatura neutra de 12 °C y 15 °C respectivamente.
Acumulador solar térmico de placa compacta con material de cambio de fase para secadores familiares
Authors: Janampa Kléber
Published: August 2021

En el presente trabajo se ha diseñado un acumulador solar térmico para mejorar la inestabilidad temporal de la energía solar en el secado familiar de productos. La estructura del acumulador se define mediante la simulación térmica en Comsol Multiphysics. El acumulador es modular, de placa compacta rectangular de cobre, cuyas dimensiones determinadas son 30 cm x 20 cm x 3 cm que encapsula 1 kg de parafina como material de cambio de fase. Para mejorar la transferencia de calor desde el material de cambio de fase, debido a la baja conductividad térmica de la parafina, se incorpora aletas internas y/o externas en el acumulador para acelerar el proceso de carga y descarga de la energía térmica. Cuando se incorporan dos unidades del acumulador en la placa colectora de un secador solar de cabina, se logra estabilizar la temperatura del aire que ingresa a la cámara de secado durante el proceso de carga del acumulador y cuando cesa la intervención de la radiación solar, la energía acumulada permite disponer de aire que ingresa a la cámara de secado con una temperatura mayor a 30 o C por un intervalo de 2 h, energía adicional que optimiza el proceso de secado del producto.
Conductividad térmica de compuestos tipo sándwich usados en la industria de la construcción
Authors: Mendoza Marco Antonio , Piñas Moya Mac Joshua , Horn Mutschler Manfred Josef , Gómez León Mónica Marcela Marcela
Published: August 2021

En las últimas décadas los compuestos tipo sándwich han tomado una mayor participación en la industria de la construcción, debido a su bajo costo y propiedades que caracterizan a estos compuestos. Entre las propiedades más importantes de estos resalta la conductividad térmica que se vincula directamente con el confort térmico en una edificación. En la actualidad, el Estado Peruano viene desarrollando proyectos en la lucha contra las heladas y el friaje, donde una de las principales intervenciones se enfoca en la construcción de viviendas sostenibles que brinden protección al poblador alto andino ante las inclemencias del clima. En ese sentido es necesario contar con materiales de construcción apropiados para las condiciones climáticas del lugar, y es ahí donde radica la importancia de esta investigación. En este trabajo se propone el estudio de la conductividad térmica a condiciones de temperatura cercanas a 0 ºC de compuestos tipo sándwich formados a partir de materiales monolíticos más usados en construcción como el drywall, ladrillo, poliestireno expandido, lana de vidrio y lana poliéster. El estudio fue realizado mediante el empleo de un equipo de placa caliente con guarda de doble muestra, construido con los lineamientos establecidos por la norma ASTM C177. Las medidas realizadas de los compuestos tipos sándwich drywall-poliestireno expandido-drywall, drywall-lana de vidrio-drywall, drywall-lana poliéster-drywall, ladrillo-poliestireno expandido-ladrillo, ladrillo-lana de vidrio-ladrillo y ladrillo-lana poliéster-ladrillo, dieron los siguientes resultados 0,0953 W.m-1.ºC-1, 0,0675 W.m-1.ºC-1, 0,0833 W.m-1.ºC-1, 0,0891 W.m-1.ºC-1, 0,0602 W.m-1.ºC-1 y 0,0709 W.m-1.ºC-1, respectivamente.
Aprovechamiento del estiércol de alpaca e ichu para la producción de briquetas como fuente de energía calorífica en Arequipa
Authors: Palo Tejada Juan Ernesto , Puma Taco Alicia Lelia , Campos Falcón Enriqueta Victoria , Colque Ollachica Danae , Figueroa Ccanahuire Isabel Karina , Chaupi Quispe Luz Mery
Published: August 2021

En este trabajo se realizaron pruebas para determinar el poder calorífico de briquetas de estiércol de alpaca e ichu y aglomerante; la proporción de la mezcla está en 80 % de estiércol de alpaca, 18% de ichu, 2% de cal y agua en medida proporcional al estiércol. Los resultados muestran la temperatura máxima que alcanza la briqueta en estudio es 500 °C medido con un termómetro infrarrojo y poder calorífico estimado para estas briquetas 4318,18 cal/g. Por los resultados obtenidos las briquetas resultantes se pueden utilizar como combustible alternativo y económico y además amigable con el medio ambiente. El estiércol de alpaca a 4000 m.s.n.m no se utiliza como abono para la agricultura en la población deSan Antonio de Chuca-Imata.
Cambios en la generación y composición de residuos domiciliarios durante la pandemia del Covid-19, estudio de caso en 8 distritos de la provincia de Arequipa, Perú
Authors: Requena Sanchez Norvin Plumieer , Carbonel Ramos Dalia Elisa
Published: August 2021

En el Perú la pandemia del COVID-19 conllevó a una cuarentena estricta desde el 15 de marzo, condición que se extendió en la provincia de Arequipa hasta el 17 de setiembre. Esta situación ha producido una serie de cambios ambientales entre los que se encuentra las variaciones en la generación y composición de residuos sólidos domiciliarios, información que a diferencia del impacto de la cuarentena en el agua o el aire no ha sido lo suficientemente recopilada y difundida. En este estudio se presentan los resultados de la caracterización de residuos sólidos domiciliarios realizado por el Equipo Técnico de Residuos Sólidos de la Facultad de Ingeniería Ambiental de la Universidad Nacional de Ingeniería en 8 distritos de la provincia de Arequipa que contó con la participación de 25 hogares. Se recopilaron datos de hábitos de generación y segregación de residuos sólidos y, luego de recibir la capacitación respectiva, los participantes proporcionaron información sobre la cantidad y composición de sus residuos generados durante 7 días (entre el 1 y 7 de setiembre). La generación per cápita del estudio fue 0.373 kg/hab./día, este valor es menor al provincial de Arequipa (0.49 kg/hab./día) lo que puede explicarse por una disminución en la capacidad de adquisición de las familias durante la cuarentena. En la composición de residuos resalta el alto porcentaje de sobras de comida (15.53%) que puede deberse a un aumento en la frecuencia con la que se cocina, mayor cantidad de alimentos preparados, almacenamiento inadecuado o un exceso en la cantidad de alimentos comprados.
Estudio de las emisiones de gases de efecto invernadero producidas por los embalses de las centrales hidroeléctricas del Perú
Authors: Villanueva Ure Justo Reynaldo , Franco Gonzales Elmar Javier , Becerra Arévalo Gilberto
Published: August 2021

El proceso de generación hidroeléctrica se compone esencialmente de tres etapas que son la del embalse de agua, la de transformación de energía hidráulica a energía eléctrica y la de entrega de la energía eléctrica para su distribución.  En la etapa del embalse se realizó la cuantificación de emisiones de gases de efecto invernadero usando la metodología propuesta por la Organización de las Naciones Unidas, denominada Panel Intergubernamental para el Cambio Climático del 2006 en diez centrales hidroeléctricas peruanas. Se concluyó que, en la primera fase de la generación hidroeléctrica, que es la del embalse, la contaminación significativa total de dióxido de carbono, CO2, llegó a ser 83947 toneladas por año y se contrastó los resultados comparando con datos obtenidos de embalses similares de hidroeléctricas brasileñas.
Collaborative Governance dalam Tata Kelola Pariwisata-Desa (Studi Pariwisata-Desa “Bumiaji Agrotourism” di Kota Wisata Batu)
Authors: Matthoriq Matthoriq , Zauhar Soesilo , Hermawan Romy
Published: August 2021

The objective of this research is examines the role of collaborative governance in rural tourism development, especially in the tourist area of "Bumiaji Agrotourism" in Tourist City of Batu. The rapid development of tourism in Batu is still dominated by the artificial tourism destinations, often the highlight in relation to the equitable distribution of welfare and sustainability of tourist development. Until today, the efforts of local governments and communities by presenting a variety of new icon types of community-based tourism destinations in Batu City do not provide assurance that tourism will remain exsist and suistain due to resource limitations in each actor. In accordance with Good Tourism Governance (GTG), tourism management efforts can no longer be charged only to one of the actors. Collaborative governance approach can be used as an alternative solution, especially in rural tourism development in Tourist City of Batu to strengthen the character of tourist destinations as well as tourism network buildings.
Environmental Governance and Climate Change Adaptation in Indonesia
Authors: Novita Asti Amelia
Published: August 2021

This paper examines environmental governance in climate change adaptation efforts in Indonesia. Climate Change has been a common concern, especially since the signing of 194 countries in the Paris Agreement. Climate change adaptation is one of the points in the Paris Agreement as an effort to implement commitments to tackle global climate change. Climate change adaptation is one of the responses made by humans in facing climate change in addition to mitigation. Adaptation is carried out to reduce vulnerability to the effects of climate change. The Indonesian government has made various climate change adaptation efforts, including preparing national policy documents such as INDC, RAN-API, and related regulations to address the impacts of climate change. However, the research results show that strengthening climate change adaptation efforts needs to be balanced with commitment from sharing parties, strengthening the role of the private sector, and proper budget planning. Committees here are associated with the alignment of central and regional policies and the compliance of local governments in implementing climate change adaptation policies. The private sector's role emphasized the contribution of activities and finance to climate change adaptation efforts through corporate social responsibility programs.
Analisis Prestasi Belajar Mahasiswa Ditinjau dari Jurusan SMA, Jenis Kelamin, Jalur Masuk, dan Asal Daerah serta Implikasinya terhadap Kebijakan Penerimaan Mahasiswa Baru
Authors: Himmah Fara
Published: August 2021

Academic performance of students, is an important thing in higher education institutions. The purpose of this study is to obtain empirical information that can be used to analyze differences in learning achievement between students from the path of entering high school majors, gender and regional origin and determine future student recruitment policies. Quantitative is methods of this research .using hypothesis a sample T-Test for comparing two different samples in pairs. The results in this study are There are significant and simultaneous influences of high school entrance and majors on student performance, There is a significant influence on high school majors on student achievement, There is a significant of gender on student IPK and there is no significant result from the region on student achievement.
Visual pollution manifestations negative impacts on the people of the Saudi Arabia
Authors:   Architectural Engineering Department, College of Engineering, University of Hail, Hail, Saudi Arabia, et al. Mohamed
Published: August 2021

Visual pollution takes many forms, but it shares its essence with regard to its relationship to confusion in the brain's processing of inconsistent visual inputs, which negatively affects the individual's health in general, and in particular his mental and psychological health. This research is shedding light on the benefits and significance of physiological health positive impacts aspects of visual pollutions. It also highlights the problems associated with Visual prolusion and suggested the way and significance of removal and getting rid of it. Negative visual views are surveyed and documented by displaying some pictures reflecting the current view of the visual pollution. It also displays the directives and plans of the ministry of municipal and rural Affairs to remove and get rid of visual pollution in the kingdom. The paper suggested that policies should be created, rules should be activated and different media should be encouraged to aware people of the importance of the removal of Visual pollutions and its hazardous on people's health as well as the general view of the environment.
Correction: Predicting Antituberculosis Drug–Induced Liver Injury Using an Interpretable Machine Learning Method: Model Development and Validation Study (Preprint)
Authors: Zhong Tao , Zhuang Zian , Dong Xiaoli , Wong Ka Hing , Wong Wing Tak , Wang Jian , He Daihai , Liu Shengyuan
Published: August 2021

UNSTRUCTURED

N/A
Recurrence of IgA Nephropathy after Kidney Transplantation in Adults
Authors: Uffing Audrey , Pérez-Saéz Maria José , Jouve Thomas , Bugnazet Mathilde , Malvezzi Paolo , Muhsin Saif A. , Lafargue Marie-Camille , Reindl-Schwaighofer Roman , Morlock Alina , Oberbauer Rainer , Buxeda Anna , Burballa Carla , Pascual Julio , von Moos Seraina , Seeger Harald , La Manna Gaetano , Comai Giorgia , Bini Claudia , Russo Luis Sanchez , Farouk Samira , Nissaisorakarn Pitchaphon , Patel Het , Agrawal Nikhil , Mastroianni-Kirsztajn Gianna , Mansur Juliana , Tedesco-Silva Hélio , Ventura Carlucci Gualberto , Agena Fabiana , David-Neto Elias , Akalin Enver , Alani Omar , Mazzali Marilda , Manfro Roberto Ceratti , Bauer Andrea Carla , Wang Aileen X. , Cheng Xingxing S. , Schold Jesse D. , Berger Stefan P. , Cravedi Paolo , Riella Leonardo V.
Published: August 2021

Background and objectives

In patients with kidney failure due to IgA nephropathy, IgA deposits can recur in a subsequent kidney transplant. The incidence, effect, and risk factors of IgA nephropathy recurrence is unclear, because most studies have been single center and sample sizes are relatively small.

Design, setting, participants, & measurements

We performed a multicenter, international, retrospective study to determine the incidence, risk factors, and treatment response of recurrent IgA nephropathy after kidney transplantation. Data were collected from all consecutive patients with biopsy-proven IgA nephropathy transplanted between 2005 and 2015, across 16 “The Post-Transplant Glomerular Disease” study centers in Europe, North America, and South America.

Results

Out of 504 transplant recipients with IgA nephropathy, recurrent IgA deposits were identified by kidney biopsy in 82 patients; cumulative incidence of recurrence was 23% at 15 years (95% confidence interval, 14 to 34). Multivariable Cox regression revealed a higher risk for recurrence of IgA deposits in patients with a pre-emptive kidney transplant (hazard ratio, 3.45; 95% confidence interval, 1.31 to 9.17) and in patients with preformed donor-specific antibodies (hazard ratio, 2.59; 95% confidence interval, 1.09 to 6.19). After kidney transplantation, development of de novo donor-specific antibodies was associated with subsequent higher risk of recurrence of IgA nephropathy (hazard ratio, 6.65; 95% confidence interval, 3.33 to 13.27). Immunosuppressive regimen was not associated with recurrent IgA nephropathy in multivariable analysis, including steroid use. Graft loss was higher in patients with recurrence of IgA nephropathy compared with patients without (hazard ratio, 3.69; 95% confidence interval, 2.04 to 6.66), resulting in 32% (95% confidence interval, 50 to 82) graft loss at 8 years after diagnosis of recurrence.

Conclusions

In our international cohort, cumulative risk of IgA nephropathy recurrence increased after transplant and was associated with a 3.7-fold greater risk of graft loss.
Conocimiento del concepto, comités y códigos de bioética en médicos residentes de la especialidad de traumatología y ortopedia
Authors: Ávila Ruiz Tania , Álvarez Hernández Ángel , González Vázquez Encarnación Angel , Mendoza Lucero Francisca María Fabiola
Published: August 2021

Introducción: La formación de un médico residente en el ámbito de la bioética es fundamental en la práctica médica ya que retoma la filosofía, sus conceptos y normas. El tener claridad en los conceptos coadyuva a su reflexión para lograr identificar las situaciones que requieren de consulta a un comité de bioética hospitalario, así como el manejo del código de la especialidad y favorecer la relación médico paciente.

Método: Se aplicó un instrumento en 36 médicos residentes de un hospital público del Estado de Puebla. Los datos son de manera anónima, voluntaria y confidencial mediante un estudio descriptivo; los resultados se muestran en porcentaje.

Resultados: El 97.2% de los médicos residentes cursaron bioética en pregrado. El 42.7% no tiene claro el concepto de bioética, 91.7% reconoció la existencia de un comité de bioética e identificó quién tiene derecho a consultarlo, sin embargo, solo el 58.3% logró discernir en qué situaciones no se debe consultar al comité. El 77.8% no ha leído el código de bioética y 86.1% desconoce el código de ética de la Sociedad Mexicana de Ortopedia.

Conclusiones: No hay claridad en el concepto de bioética, ni conocimiento adecuado en la consulta del comité de bioética en los médicos residentes de traumatología y ortopedia lo cual podría indicar la falta de interés y la poca la utilidad que le otorgan a esta disciplina para su aplicación en la práctica clínica.
Simulación clínica interprofesional con estudiantes de medicina, de enfermería y de auxiliares de enfermería
Authors: Chavarría María , Jiménez María José , Negredo Mónica , Bardallo Lola , Esteban Sílvia , Garcimartín Paloma , Giraldo Priscila , Molina Luis , Girvent Meritxell , Nolla Joan , Pérez Jorge
Published: August 2021

Introducción: La WHO recomienda la educación interprofesional (EIP) donde 2 o más estudiantes de 2 o más profesiones sanitarias aprenden juntos para trabajar juntos en el futuro. La simulación clínica, donde los estudiantes realizan acciones sanitarias parecidas a la realidad, pero sin riesgo para el paciente, se ha visto como un buen método para fomentar la EIP.

Objetivo: Implementar unas experiencias piloto de EIP en simulación clínica con estudiantes universitarios (de medicina y de enfermería) y de formación profesional (de auxiliares de enfermería) para que en el caso de éxito introducirlas en los estudios reglados de Medicina y de Enfermería.

Método: Se realizaron 2 experiencias piloto multidisciplinarias en el campo de la simulación clínica. Se diseñaron 3 casos clínicos donde tenían que intervenir alumnos de los 3 estudios. En cada uno de los casos, el primer contacto con la situación lo asumía un estudiante de cada una de las 3 titulaciones. En todos los casos se siguieron las 4 fases de la simulación clínica y al finalizar cada experiencia los estudiantes participantes contestaron una encuesta de satisfacción sobre su percepción de aprendizaje, instructores, aspectos organizativos y satisfacción general.

Resultados: Las experiencias piloto fueron consideradas exitosas por la percepción positiva de los profesores implicados manifestada en reuniones posteriores de reflexión y por la gran satisfacción generada entre los estudiantes participantes.

Conclusiones: A partir del éxito de las pruebas piloto, la educación interprofesional se ha introducido en los currículums reglados de los estudios de medicina y de enfermería donde se realizan simulaciones con estudiantes de dichas carreras y de auxiliares de enfermería. Se resalta el hecho novedoso de la participación de estudiantes no universitarios que podría estimular experiencias similares en estudios de ciencias de la salud.
Evaluación de los residentes como docentes clínicos utilizando el Maastricht Clinical Teaching Questionnaire
Authors: Ladenheim Roberta , Giannasi Sergio , Durante Eduardo
Published: August 2021

Introducción: La docencia clínica en las residencias se realiza en forma simultánea por médicos de planta y residentes de años superiores. A pesar de su relevancia como docentes, la mayoría de las veces los residentes no poseen formación específica para este rol. La manera en que los residentes se desempeñan como docentes clínicos no está extensamente estudiada.

Objetivo: Describir las características de los residentes como docentes clínicos de otros residentes y alumnos de grado en medicina Interna en un hospital Universitario.

Método: Se realizó un estudio descriptivo de corte transversal utilizando el Maastricht Clinical Teaching Questionnaire (MCTQ) para describir a los residentes como docentes de otros residentes y alumnos. Se comparó a los residentes como docentes con los médicos de planta y a los residentes de los primeros años con los que se encontraban avanzados en sus programas.

Resultados: 36 residentes fueron evaluados. El desempeño fue satisfactorio en el modelo de rol (media 4.00 DS 0.81) y clima de aprendizaje (media 4.36 DS 0.84), pero los residentes no dieron consistentemente retroalimentación (media 3.67 DS 1.15), incentivaron a los alumnos a explorar sus debilidades y fortalezas (media 3.40 DS 1.08), ni fomentaron que los alumnos formularan (media 3.57 DS 1.05) y cumplieran (media 3.58 DS 1.10) sus objetivos de aprendizaje. Los residentes se desempeñaron peor que los médicos de planta. La manera en que desarrollan la docencia se modificó a medida que avanzaron en su programa.

Conclusiones: Los residentes como docentes clínicos presentaron buen desempeño como modelo de rol y en la creación de un clima de aprendizaje propicio, pero mostraron un desempeño que podría ser mejorado en otros roles del buen docente clínico.
Producción científica e impacto del sistema de ciencia de Latinoamérica y el Caribe en revistas de la región
Authors: Ronda-Pupo Guillermo Armando
Published: August 2021

El objetivo del estudio es analizar el ritmo de crecimiento de la producción científica latinoamericana y del Caribe en revistas de la región incluidas en el Journal of Citation Reports de Clarivate Analytics Web of Science y su impacto con la utilización de un modelo alométrico. Se analizaron 179 219 documentos publicados entre 2000 y 2017 que recibieron 233 352 citas. Para medir el impacto se utilizó una ventana de citaciones fija de tres años (t0 + 2). El exponente de la relación resultó α = 0,75± 0.02 y sugiere que la productividad crece más rápido que el impacto.
IMPACTO Y FUNCIONAMIENTO DIFERENCIAL DE LOS ÍTEMS RESPECTO AL GÉNERO EN EL TEST DE EFICACIA LECTORA (TECLE)
Authors: Costa Ball Daniel , Gründel María , Cuadro Ariel
Published: August 2021

Este trabajo tiene como objetivo estudiar el posible funcionamiento diferencial de los ítems (FDI) que componen la Prueba de Eficacia Lectora (TECLE). Se utilizó el estadístico de Mantel-Haenszelt (MH) como procedimiento de detección del FDI para evaluar si los ítems del TECLE funcionan de forma distinta en grupos igualados en función del género. La muestra está conformada por 1159 alumnos de educación primaria privada con edades comprendidas entre 9 y 12 años (50,5% varones y 49,5% niñas). Los resultados del análisis del FDI encontraron que según el estadístico MH que el porcentaje de ítems con FDI es del 6,25%. Independientemente de que puedan existir diferencias reales en las habilidades de eficacia lectora entre niñas y niños en cuatro del los 64 ítems del TECLE, no es preciso realizar una baremación por sexo.  Habría que considerar continuar con los estudios con jueces expertos en el tema para despejar la sospecha de FDI.
PROPIEDADES PSICOMÉTRICAS DE UNA PRUEBA EXPERIMENTAL PARA LA EVALUACIÓN DEL NIVEL ORTOGRÁFICO
Authors: Costa Ball Daniel , Palombo Ana Laura , Cuadro Ariel
Published: August 2021

Se presenta el desarrollo de una prueba para la evaluación del nivel ortográfico de escolares (Test de Eficacia Ortográfica: TEO),  con  el objetivo de contribuir a las prácticas educativas, así como al diagnóstico de una competencia que impacta fuertemente en la escritura. A partir de una muestra de 693 sujetos de 2º a 6º de primaria de cuatro colegios de Montevideo se analizaron las propiedades psicométricas de los ítems que componen la prueba. Con una segunda muestra de 123 sujetos de un único colegio de Montevideo se estudió la fiabilidad de la prueba con el método de test-retest. Los estudios de validez de contenido, análisis de ítem, dimensionalidad y fiabilidad, han aportado evidencia de la validez de una estructura unidimensional; acorde con los planteamientos teóricos. En conclusión, se puede afirmar que está prueba de nivel ortográfico (TEO) constituye un instrumento de medida válido y fiable que permite explorar a partir de un único factor el nivel  ortográfico.
Oral bisacodyl is effective and safe for short term treatment of chronic constipation
Authors: Vaishnav Akanksha
Published: August 2021

A clinical decision report using:

Kamm MA, Mueller-Lissner S, Wald A, Richter E, Swallow R, Gessner U. Oral bisacodyl is effective and well-tolerated in patients with chronic constipation. Clin Gastroenterol Hepatol. 2011;9(7):577-583. https://doi.org/10.1016/j.cgh.2011.03.026

to evaluate potential long term treatment with oral Bisacodyl in a patient with a history of chronic constipation and recent non-surgical treatment of ischemic colitis.
Arahan pengembangan destinasi wisata kawasan kaldera batur berbasis sistem informasi geografis (sig)
Authors: Suprapto Nyoman Arto , Sutiarso Moh. Agus
Published: August 2021

Kawasan Kaldera Batur memiliki beragam potensi pengembangan wisata namun juga sangat dibatasi pengembangannya karena kawasan ini ditetapkan sebagai kawasan konservasi di dalam rencana tata ruang Kabupaten Bangli dan Provinsi Bali. Pengembangan Kawasan dilakukan untuk mengakomodasi kepentingan ekonomi masyarakat namun sekaligus juga menjaga fungsi lindung kawasan tersebut. Dualisme fungsi kawasan tersebut mengharuskan adanya sebuah pendekatan yang yang tepat dalam mengembangkan destinasi wisata Kaldera Batur agar tercapai pembangunan pariwisata yang berkelanjutan. Salah satunya adalah pengembangan destinasi wisata berbasis Sistem Informasi Geografis (SIG). Arahan pengembangan destinasi wisata khususnya penyediaan fasilitas pariwisata pada Kawasan Kaldera Batur dilakukan dengan pendekatan kemampuan lahan yang dianalisis dengan Teknologi SIG. Berdasarkan hasil analisis ditemukan bahwa kelas kemampuan lahan pada Kawasan Kaldera Batur yang cocok untuk pengembangan fasilitas penunjang pariwisata adalah Kelas D dan E yaitu kelas lahan dengan kemampuan pengembangan agak tinggi dan tinggi seluas 14.096 Ha yang tersebar di Desa Batur Tengah, Batur Selatan, Songan A, Sukawana dan Abangbatudinding.
Max Weber’s Analysis of Plebiscitary Leadership and the Debate on Multiple Modernities
Authors:   Sociological Institute of FCTAS RAS, St. Petersburg, Russia, Maslovskiy M.V.
Published: August 2021

The article considers Max Weber’s model of plebiscitary leadership and historical examples of plebiscitary democracy. It is argued that there is no clear distinction between plebiscitary democracy and dictatorship inWeber’s writings. As Stefan Breuer demonstrates, such a distinction allows us to broaden the application of Weberian concepts. Plebiscitary elements can be seen in the political life of non-Western states, which have been discussed from the multiple modernities perspective. However, while that perspective develops the Weberian sociological tradition, its representatives mostly do not use the concept of plebiscitary leadership. Thus, Shmuel Eisenstadt draws primarily on Weber’s sociology of religion in his analysis of different types of modernity. Specifically, Eisenstadt considers the impact of civilizational legacies on political processes in India and Latin America. Peter Wagner discusses the relevance of Weber’s rationalization thesis and theory of capitalism rather than the concepts of Weberian political sociology. In his study of democratization in Brazil and South Africa, Wagner emphasizes the progressive character of political changes but does not consider the possibility of a reversal of these processes. The article argues that the contemporary reconstruction of Weber’s model of plebiscitary leadership can complement the analyses of democratization in non-Western societies from the multiple modernities perspective.
Max Weber and the New Critical Theory of Hartmut Rosa: Updating the Classics
Authors:   Lipetsk State Pedagogical Semenov-Tyan-Shansky University, Russia, Kataev D.V.
Published: August 2021

The article discusses a key issue for Russian and international Max Weber Studies: the epistemological possibilities and place of Weberian sociology in modern social theory. Discussion articles by well-known Russian scientists — who sharply criticized the actualizing direction of Weberian studies in general, and the religious, cultural, and sociological orientation in particular — are contrasted with the re-actualization and rethinking of key Weberian themes in the “New Critical Theory” of the influential German sociologist Hartmut Rosa. Such a projection will make it possible, on the one hand, to thematize the axiomatic assertion about the heuristic rather than concrete-content relevance of the classics; on the other hand, it will provide an opportunity to read Weber as a macrosociologist. In the original, criticized, and often rejected sociology of Rosa, Weber appears not only as a predecessor whose mention enhances the relevance of the new theoretical framework, but, above all, as an analyst and diagnostician of early modernity. Weber’s main ideas and theoretical constructions are organically built into Rosa’s methodological framework: analysis-diagnosis-praxis. The analysis of rationalization as a universal historical process of modernity in Weber’s sociology is rethought by Rosa as expansion and acceleration; disenchantment becomes a diagnosis of modernity and is recoded into alienation, while the concept of charisma is transformed into the key concept of resonance.
Max Weber: Milestones of an Intellectual Biography
Authors:   HSE University, Moscow, Russia, Dmitriev T.A.
Published: August 2021

The article reviews current historical research on the life and work of Max Weber. The completion of the Max Weber Gesamtausgabe (Collected Works) by the Mohr Siebeck publishing house not only made it possible to put a new textual basis behind the systematization of Weber’s legacy — which is key for a general theoretical grounding and self-explanation of sociology — but also elevated historical and biographical studies devoted to Weber. This has been achieved by introducing many new sources and clarifying old ones. The article is based on an analysis of Weber’s most recent intellectual biography published in 2019. It was written by Gangolf Hübinger, a German academic and a member of the MWG editorial staff since 2004. Hübinger’s book presents Weber’s life as a convergence of some concentric circles that revolve around several major themes. Among them are social and cultural features of “organized modernity” as the turning point era in the history of the West; the formative years of Weber as an individual and a scholar; the intellectualization of modernity and its consequences; Weber’s invention of a new academic discipline, political sociology; the intellectual networks with which Weber was involved as a scholar and politician. An important advantage of this new biography is that it provides a detailed description of the current study of Weber’s theoretical legacy and the prospects for the development of a “Weberian paradigm” in today’s social science and humanities.
Successful adjunctive treatment of compartment syndrome due to acute isocyanate inhalation using hyperbaric oxygen therapy: case report
Authors:   Dept of Emergency Medicine, Chonnam National University Medical School, Dong-gu, Gwangju, Republic of Korea, Lee Sungmin , Han Junho , Heo Tag
Published: August 2021

Introduction: Isocyanates are the raw materials that make up all polyurethane products. Isocyanate is a powerful irritant to the mucosal membrane of the respiratory tract, eyes and skin. Pulmonary symptoms, especially occupational asthma, are predominant manifestations of isocyanate toxicity. Case report: We report mental changes and compartment syndrome complicated with rhabdomyolysis as an extraordinary manifestation of acute isocyanate toxicity observed in a patient during the waterproofing of a water tank. A 58- year-old man recovered consciousness after six hours in the emergency department and complained of severe pain in the lower leg. The results of his laboratory test showed that his serum creatine kinase (15,250 IU/L) level had increased. The tissue pressure in both the lower legs had increased to 180 mmHg/170 mmHg (right/left). We performed fasciotomy on the second day of hospitalization. The patient was provided hyperbaric oxygen (HBO2) therapy of 2.0 ATA for 90 minutes twice a day for seven days. His condition gradually improved over five months, and he did not require amputation. He had a mild neurological disorder in his foot and was transferred to a rehabilitation center five months after hospitalization. Conclusion: It is important to note that when working with isocyanate, non-specific complications such as a change in consciousness as well as compartment syndrome with rhabdomyolysis can occur in a confined space or high-temperature environment. In addition, we found that compartment syndrome caused by isocyanate toxicity can be effectively treated with fasciotomy and HBO2 therapy.
The impact of IT governance wisdom on board decision-making: A perspective of the philosophy of The Art of War
Authors: Chen Le , Pavone Pietro
Published: August 2021

Board decision-making is a complex process. It is represented by reasoning for choosing the most suitable alternative within a series of options for the operation of the corporation. In practice, strategic decision-making is an important function of the board of directors, especially in the information age. Although there are various determinants of the board for carrying out decision-making, there has been little research concerning the impact of information technology (IT) governance wisdom on board decision-making. This study seeks to investigate the origin of IT governance and analyze IT governance wisdom from the perspective of the philosophical thinking of The Art of War. The analysis indicates that the concept of IT governance must have been produced no earlier than the late 1990s, highly likely at the beginning of the 21st century. In addition, this study presents the results of qualitative field research of a Chinese information and communication technology (ICT) company which indicates that it has an important meaning in explaining IT governance wisdom might have a significant influence on board decision-making. In summary, the importance of information governance wisdom in the decision-making process of the board of directors is also a reflection of intelligent management while considering the interests of shareholders in the digital era.
Chronic Rhinosinusitis
Authors: Tajudeen Bobby
Published: August 2021

Chronic sinusitis (CRS) is a long-standing mucosal inflammatory disease of the sinonasal tract that results in significant impairment in patient quality of life. The pathogenic determinants of disease include chronic mucosal inflammation, local microbial colonization, and mucociliary dysfunction. A thorough understanding of this tripartite model allows for endotyping and tailored therapy. Medical therapy in the form of oral and/or topical therapy is imperative to reduce mucosal inflammation, treat microbial infection, and enhance mucociliary function. Functional endoscopic sinus surgery (FESS) serves to surgically reduce inflammatory load, ventilate the sinuses, augment installation of topical therapy, and provide tissue for endotyping. The end result of well-performed surgery is a unified sinus cavity augmented for improved medical therapy. Newer therapeutics, such as biologic therapies, target TH-2 driven mucosal inflammation and are gaining an emerging role in the management of CRS; however, the role of these therapies is not well defined in the current treatment paradigm.

This review contains figures, tables and references
Key words: chronic sinusitis, chronic rhinosinusitis, functional endoscopic sinus surgery, topical steroid therapy, endotype, structured histopathology, nasal polyps, biologic therapy, mucociliary dysfunction, biofilms
Inhomogeneities of the earth’s crust of the Aldan-Stanovoy shield along the 3-DV profile (Eastern Siberia, Russia
Authors: Stogny V. V. , Stogny G. A.
Published: August 2021

Profile 3-DV (Skovorodino-Tommot) crosses in the sublatitudinal direction the Stanovoy and Aldan megablocks of the Aldan-Stanovoy shield. As the basic elements of the Earth’s crust section along the profile 3-DV, a technique was adopted for identifying regional inhomogeneities of the lithosphere based on the results of the analysis of seismic and gravimetric data with subsequent typification of their nature. According to the SRM-CMP data, in the upper part of the section (up to 35 km) of the Aldan megablock, the Yakokut and Chulman heterogeneities are distinguished, and the Stanovoy megablock — the Kalara-Dzhugdzhur heterogeneity. The Yakokut and Chulman seismic inhomogeneities in the gravitational field correspond to minima with an the amplitude of up to 25 mGal. The gravitational field of the Kalara-Dzhugdzhur heterogeneity is mosaic and reflects its block structure.

It is shown that the deep structure of the Aldan megablock in the area of the 3-DV profile is determined by the Yakokut granite-gneiss dome and Chulman sublateral decompaction zone, and the upper part (0—25 km) of the Stanovoy megablock is represented by the Kalar-Dzhugdzhur structure, composed of the Stanovoy complex of rocks  and blocks of highpressure granulites. A significant (up to 10 km) increase in the thickness of the earth’s crust of the Aldan megablock is explained by the presence of the upper layer juvenile crust formed in the Paleoproterozoic as a result of regional metamorphism of igneous rocks. The Earth’s crust of the Stanovoy megablock is tectonically rebuilt for almost the entire thickness of up to 40 km during the Mesozoic collision of the Precambrian North Asian and Sino-Korean cratons.

The Yakokut granite-gneiss dome, in accordance with the proposed model of the structure of the Earth’s crust of the Aldan megablock, is the ore-controlling structure of the Central Aldan gold-bearing region, and highpressure granulites of the Zverevsky block of the Kalara-Dzhugdzhur heterogeneity of the Stanovoy megablock served as a source of gold in the Chako-Berkakit ore cluster.