bluuebunny/crossref_metadata_2025 huggingface dataset:
Bond strength and marginal adaptation of a novel root-end filling material
Authors: Aly Yousra , El Shershaby Sherif , El-Sherif Sammar
Published: August 2020

Background

Apicoectomy with retrograde filling is considered as a tooth saver. Mineral trioxide aggregate (MTA) is mostly recommended as a root-end filling material as it is proved to have excellent sealing ability and hard tissue repair. Aside from these advantages, MTA has some disadvantages, such as weak handling properties, long setting time, and discoloration potential. Nanotechnology is now undergoing rapid development. Recently, experimental nano-white mineral trioxide aggregate (nano-WMTA) was prepared and introduced by NanoTech Egypt (Al Giza, Egypt) as a root-end filling material. The manufacturers claim that it has similar composition to white MTA, but with the reduction of its particle size to obtain a high specific powder surface area that may lead to a better and faster hydration process. It seems worthy to study the bond strength and marginal adaptation of the newly introduced nano root-end filling materials and compare it with the conventionally used MTA in root-end cavities.

Results

In push-out test, no statistically significant difference was found between nano-WMTA and MTA Angelus groups where p = 0.459. The nano-WMTA group recorded the highest mean value. For scanning electron microscope evaluation, there was a statistically significant difference between the nano-WMTA and MTA Angelus groups where p < 0.001. The MTA Angelus group recorded the highest mean value of gap distance.

Conclusions

Nano-WMTA recorded a similar bond strength to MTA Angelus. The nano-WMTA showed significantly higher marginal adaptation to root-end cavity than MTA Angelus.
Monitoring and analysis of rice pathogen Ustilaginoidea virens isolates with resistance to sterol demethylation inhibitors in China
Authors: Pan Xiayan , Cao Huijuan , Yu Junjie , Yu Mina , Qi Zhongqiang , Song Tianqiao , Du Yan , Yong Mingli , Zhang Rongsheng , Yin Xiaole , Liu Yongfeng
Published: August 2020

Rice false smut (RFS), caused by Ustilaginoidea virens (Cooke) Takah, is an important fungal disease of rice. In China, sterol demethylation inhibitors (DMIs) are common fungicides used to control RFS. In a previous study, we detected two propiconazole-resistant U. virens isolates in 2015 in Huai’an city, Jiangsu Province, China. In the current study, we detected six propiconazole-resistant isolates out of 180 U. virens isolates collected from rice fields in Jiangsu Province in 2017, and found they were from three different places (Xuzhou, Huai’an and Jintan). All these six propiconazole-resistant isolates were cross-resistant to three other sterol demethylation inhibitor (DMI) fungicides, i.e. difenoconazole, tebuconazole, and epoxiconazole. Among them, two isolates (2017–61 and 2017–170) had high fitness. Through sequencing and RT-qPCR analysis, we found that the expression levels of CYP51 and its encoded protein were significantly increased in the propiconazole-resistant isolates with a “CC” insertion mutation upstream of the CYP51 coding region compared to the propiconazole-sensitive isolates. In addition, propiconazole stimulated CYP51 expression in all isolates. Propiconazole also stimulated the accumulation of CYP51 protein in propiconazole-sensitive isolates and propiconazole-resistant isolates without mutation, but not in propiconazole-resistant isolates with the “CC” mutation. According to JASPAR database analysis, the predicated functional binding sites for propiconazole-resistant isolates with a “CC” insertion mutation and propiconazole-sensitive isolates were different. Given the high fitness of the propiconazole-resistant isolates, the development of resistance to DMIs in U. virens should be monitored. Furthermore, we speculated that the over-expression of CYP51 may contribute to DMI resistance in U. virens with the “CC” insertion mutation.
DWI as a biomarker of renal function in children with CKD: what is the potential?
Authors: Emad-Eldin Sally , Yadav Sunil , Galal Rasha Essam Eldin , Elzayat Wessam Abdelrahman
Published: August 2020

Background

Evaluation of renal microstructure is pivotal for diagnosing and monitoring chronic renal disease. DWI has been proved to be practicable and reliable examination for the assessment of renal function and parenchymal damage in some renal diseases. Our aim is to appraise DWI sequence and ADC measurement as a potential tool of renal function assessment as well as establishing a possible relationship between the different CKD stages and the renal parenchymal ADC values changes.

Results

Regarding the cause of CKD, nine patients (45%) had glomerulonephritis, 5 patients (25%) had hemolytic uremic syndrome, 2 patients (10%) had lupus nephritis, 2 patients (10%) had nepheronophthisis, and 1 patient (1.5%) had infantile nepherosis, whereas the cause of CKD was unknown in 1 patient (1.5%).

The stages of CKD were classified according to KIDGO guidelines: 6 patients (30%) were stage 1, 4 patients (20%) were stage 2, 3 patients (15%) were stage 3, 2 patients (10%) were stage 4, and 5 patients (25%) were stage 5. The patients’ group (group A) had a mean ADC value (1.85 × 10−3 ± 0.24) which was significantly lower than that of the control group (group B) (2.21 × 10−3 ± 0.12). As for the correlation between stage of CKD and ADC, we found it to be a moderate negative one with r’ value of − .655 and a significant p value of < 0.001.

Conclusion

DWI is recognized as a promising imaging tool that can take part in the assessment of the morphological and functional changes in diffuse renal parenchymal disease, hence playing an important role in the early diagnosis and staging of chronic kidney disease.
Patient-Centered Approach to Benefit–Risk Characterization Using Number Needed to Benefit and Number Needed to Harm: Advanced Non–Small-Cell Lung Cancer
Authors: Raju Gokaraju K. , Khozin Sean , Gurumurthi Karthik , Domike Reuben , Woodcock Janet
Published: August 2020

This work summarizes the benefit and risk of the results of clinical trials submitted to the US Food and Drug Administration of therapies for the treatment of non–small cell lung cancer (NSCLC) using number needed to benefit (NNB) and number needed to harm (NNH) metrics. NNB and NNH metrics have been reported as potentially being more patient centric and more intuitive to medical practitioners than more common metrics, such as the hazard ratio, and valuable to medical practitioners in complementing other metrics, such as the median time to event. This approach involved the characterization of efficacy and safety results in terms of NNB and NNH of 30 clinical trials in advanced NSCLC supporting US Food and Drug Administration approval decisions from 2003 to 2017. We assessed trends of NNB over time of treatment (eg, for programmed death 1 inhibitors) and variation of NNB across subpopulations (eg, characterized by epidermal growth factor receptor mutation, programmed death ligand 1 expression, Eastern Cooperative Oncology Group performance status, age, and extent of disease progression). Furthermore, the evolution of NNB of treatments for advanced NSCLC was charted from 2003 to 2017. Across subpopulations, NNB, on average, was 4 patients for approved targeted therapies in molecularly enriched populations, 11 patients for approved therapies in nonmolecularly enriched populations, and 23 patients for withdrawn or unapproved therapies. Furthermore, the NNB analysis showed variation for attributes of epidermal growth factor receptor mutations, level of programmed death 1 expression, Eastern Cooperative Oncology Group performance status, etc. When considering the best-case subpopulations and available drugs, the NNB frontier reduced from an estimated value of 7.7 in 2003 to an estimated value of 2.5 in 2017 at the estimated median overall survival—equal to 6 months—of an untreated patient.
Revisiting early-stage COVID-19 strategy options
Authors: Machanick Philip
Published: August 2020

Background: Early-stage interventions in a potential pandemic are important to understand as they can make the difference between runaway exponential growth that is hard to turn back and stopping the spread before it gets that far. COVID19 is an interesting case study because there have been very different outcomes in different localities. These variations are best studied after the fact if precision is the goal; while a pandemic is still unfolding less precise analysis is of value in attempting to guide localities to learn lessons of those that preceded them.

Methods: I examine three factors that could differentiate strategy: asymptomatic spread, differences in use of the Bacillus Calmette-Guerin (BCG) tuberculosis vaccine and cloth face masks.

Results: Differences in disease progression as well as the possibility of alternative strategies to prevent COVID-19 from entering the runaway phase or damping it down later can be elucidated by a study of asymptomatic infection. A study to demonstrate not only what fraction are asymptomatic but how contagious they are will also inform policy on universal mask wearing.

Conclusions: While a COVID-19 outbreak is at a level that makes accurate trace-and test possible, investigation of asymptomatic transmission is viable and should be attempted to enhance understanding of spread and variability in the disease as well as policy options for slowing the spread.
VIRdb 2.0: Interactive analysis of comorbidity conditions associated with vitiligo pathogenesis using co-expression network-based approach
Authors: Srivastava Priyansh , Talwar Mehak , Yadav Aishwarya , Choudhary Alakto , Mohanty Sabyasachi , Bharti Samuel , Narad Priyanka , Sengupta Abhishek
Published: August 2020

Vitiligo is a disease of mysterious origins in the context of its occurrence and pathogenesis. The autoinflammatory theory is perhaps the most widely accepted theory that discusses the occurrence of Vitiligo. The theory elaborates the clinical association of vitiligo with autoimmune disorders such as Psoriasis, Multiple Sclerosis and Rheumatoid Arthritis and Diabetes. In the present work, we discuss the comprehensive set of differentially co-expressed genes involved in the crosstalk events between Vitiligo and associated autoimmune disorders (Psoriasis, Multiple Sclerosis and Rheumatoid Arthritis). We progress our previous tool, Vitiligo Information Resource (VIRdb), and incorporate into it a compendium of Vitiligo-related multi-omics datasets and present it as VIRdb 2.0. It is available as a web-resource consisting of statistically sound and manually curated information. VIRdb 2.0 is an integrative database as its datasets are connected to KEGG, STRING, GeneCards, SwissProt, NPASS. Through the present study, we communicate the major updates and expansions in the VIRdb and deliver the new version as VIRdb 2.0. VIRdb 2.0 offers the maximum user interactivity along with ease of navigation. We envision that VIRdb 2.0 will be pertinent for the researchers and clinicians engaged in drug development for vitiligo.
Semiconductor converters of electrical energy
Authors: Prohorov Viktor
Published: August 2020

The textbook considers the need, principles and methods of mutual conversion of parameters of electric energy at DC and AC for stationary and Autonomous objects. Features of operation of power electronics elements in specific conditions of their continuous high-frequency switching are described. Low-current control systems that provide the necessary logic for the operation of Executive power devices of converters are considered. A large number of specific practical electrical diagrams of electric energy converters are given.
It is intended for students studying in the direction of 13.03.02 "electric power and electrical engineering". It can be useful for graduate students and specialists involved in the development and operation of electric power converters.
Features of accounting in trade and public catering
Authors: Kachan Natal'ya , Novosel'ceva Svetlana
Published: August 2020

The textbook deals with the main issues of setting up accounting of commodity transactions in wholesale and retail organizations, public catering enterprises, including the system of consumer cooperation. This takes into account the features of the organization of inventory accounting in the book and magazine form.

Meets the requirements of the Federal state educational standards of secondary vocational education.

Recommended for students of the specialty Economics and accounting (by industry)" to study the discipline "Features of accounting in organizations of various types of activity". It can be useful for practitioners of trade and public catering."
Strategic management
Authors: Sirotkin Sergey , Kel'chevskaya Natal'ya
Published: August 2020

The textbook outlines the basics of strategic management in an industrial enterprise. In particular, the concept and types of industrial enterprise strategies are considered, the methodological basis for the formation of corporate, business and functional strategies is described, as well as approaches to evaluating the effectiveness of the strategy and methods for selecting the optimal strategy of an industrial enterprise are presented.
Meets the requirements of the Federal state educational standards of higher education of the latest generation.
For undergraduate students studying in the areas of "Economics" and "Management", postgraduate students, teachers and specialists in the field of strategic management.
Big data augments emotional labour and organisational outcomes
Authors: Chen Jing
Published: August 2020

Marketing managers and practitioners believe that effective emotional labour strategy and big data techniques are essential elements for firms to optimise customer service encounters. However, no common understanding of emotional labour in a big data context exists, and knowledge about
how big data techniques affect emotional labour's service delivery is limited. In this study, I use emotional regulation and role/script theories to propose ways in which surface acting decreases and deep acting increases customers' perceived customer orientation (PCO), resulting in enhanced
word of mouth (WOM). Because big data analytics tools provide information to shield employees from emotional dissonance and depletion, this study further proposes that big data analytics will augment the aforementioned benefits. However, the influence of big data analytics may depend on a
firm's data verification ability. Lastly this study suggests that firms strengthen their data verification capability to achieve the big data bonus.
Non-invasive single-shot recovery of a point-spread function of a memory effect based scattering imaging system
Authors: Wu Tengfei , Dong Jonathan , Gigan Sylvain
Published: August 2020

Accessing the point-spread function (PSF) of a complex optical system is important for a variety of imaging applications. However, placing an invasive point source is often impractical, and estimating it blindly with multiple frames is slow and requires a complex nonlinear optimization. Here, we introduce a simple single-shot method to noninvasively recover the accurate PSF of an isoplanatic imaging system, in the context of multiple light scattering. Our approach is based on the reconstruction of any unknown sparse hidden object using the autocorrelation imaging technique, followed by a deconvolution with a blur kernel derived from the statistics of a speckle pattern. A deconvolution on the camera image then retrieves the accurate PSF of the system, enabling further imaging applications. We demonstrate numerically and experimentally the effectiveness of this approach compared to previous deconvolution techniques.
Temporal shaping and time-varying orbital angular momentum of displaced vortices
Authors: Hosseini Fazele , Sadeghzadeh Mohammad A. , Rahmani Amir , Laussy Fabrice P. , Dominici Lorenzo
Published: August 2020

The fundamental mode of rotation in quantum fluids is given by a vortex whose quantized value yields the orbital angular momentum (OAM) per particle. If the vortex is displaced (off-centered) from the reference point for rotation, the angular momentum is reduced and becomes fractional. Such displaced vortices can further exhibit a peculiar dynamics in the presence of confining potentials or couplings to other fields. We study analytically a number of 2D systems where displaced vortices exhibit a noteworthy dynamics, including time-varying self-sustained oscillation of the OAM, complex reshaping of their morphology with possible creation of vortex–antivortex pairs, and peculiar trajectories for the vortex core with sequences of strong accelerations and decelerations that can even send the core to infinity and bring it back. Interestingly, these do not have to occur conjointly, with complex time dynamics of the vortex core and/or their wavepacket morphology possibly taking place without affecting the total OAM. Our results generalize to simple and fundamental systems a phenomenology recently reported with Rabi-coupled bosonic fields, showing their wider relevance and opening prospects for new types of control and structuring of the angular momentum of light and/or quantum fluids.
Sketchbook as therapist: Self-authorship and the art of making picturebooks
Authors: Pedler Caroline
Published: August 2020

To self-author means to have the capacity to make coherent and informed decisions based on one’s internal beliefs and to not rely on, or be swayed by, external sources; to trust one’s internal voice and identity. In this article, I look to self-authorship as a framework to enable the illustrator to better understand personal engagement and experience of practice and visual identity through critically informed decision-making based on one’s internal beliefs; using self-authorship as a phenomenological approach to practice, encouraging the exploration of and reflection on the individual facets of process and self with a more reflective and critical eye. Two case studies set the foundation of this article, and in case study one, I reflect on using personal sketchbooks created on a master’s degree and later during a period of great personal distress. As an established illustrator, I explore the way these sketchbooks have revealed the lengthy steps of redefinition of my practice over the past decade or more. Presenting a renewed ‘sense of identity’ for me as practitioner and for the work I create. Case study two is a prelude to the conclusion and sets in place a context for my own self-authorship as a picturebook maker. Building on Fauchon and Gannon’s Manifesto for Illustration Pedagogy, through personal exploration of self-authorship and the role of the sketchbook, this article presents the use and analysis of the sketchbook and mark making as a route to 'visual self-discovery' towards a more authentic picturebook practice.
Relationship between somatic cell counts and subclinical mastitis in lactating dairy cows
Authors: Sumon S. M. Mostafizur Rahaman , Parvin Mst. Sonia , Ehsan Md. Amimul , Islam Md. Taohidul
Published: August 2020

Background and Aim: Subclinical mastitis (SCM) is one of the most prevalent diseases of dairy cows, and somatic cell count (SCC) is widely used to determine SCM and milk quality. However, setting the threshold of SCC is very important. This study aimed to determine the cow-level threshold of SCC to differentiate milk of SCM affected cows from normal milk in Bangladesh.

Materials and Methods: Sensitivity (Se) and specificity (Sp) along with other characteristics of different thresholds of SCC were determined considering the bacterial culture as the gold standard test. Three definitions of intramammary infection (IMI) were set based on the group of pathogens involved. Five categories of SCC thresholds were considered for analysis.

Results: Se and Sp of thresholds of SCC greatly varied as definitions of IMI changed. Irrespective of SCC thresholds, Se increased when isolation of major pathogens included in IMI definitions. Se decreased when SCC thresholds increased (from 100 to 300 × 103 cells/mL) for all IMI definitions and ranged from 60.6% to 20.3%. The highest Se was found at low SCC threshold (100 × 103 cells/mL), which resulted in less false-negative outcome. On the other hand, Sp increased with the increment of SCC thresholds giving rise to a less false-positive outcome.

Conclusion: The cow-level SCC threshold of 100 × 103 cells/mL was found appropriate to identify subclinical IMI of dairy cows.
ANÁLISE DA CONFIGURAÇÃO TERRITORIAL DO SISTEMA DE ESGOTAMENTO SANITÁRIO E DOS CASOS DE DIARREIA NO BAIRRO PAJUÇARA, NATAL/RN
Authors: Moura Diogo Felipe Santos de , Troleis Adriano Lima , Lopes Bruno Silva
Published: August 2020

O presente artigo discute a configuração territorial do sistema de esgotamento sanitário e sua relação com os casos de diarreia no bairro Pajuçara, Natal/RN. Levou-se em consideração o sistema de coleta de esgoto, a presença de esgoto nas ruas e as notificações da doença. A metodologia compreendeu duas etapas: teórica e empírica. Na teórica, foram realizados levantamentos bibliográficos sobre o sistema de esgotamento sanitário, saúde humana, diarreia e meio ambiente. Nesse contexto destacaram-se os referenciais: Santos (2006 e 2008), Brasil (2006 e 2007), Monken e Barcellos (2005) e Sotero (2010). Na empírica, foram adquiridos dados de diarreia e esgotamento sanitário através da Amostragem Espacial por Quadrícula, com a aplicação de 468 formulários, e do método de interpolação kernel e a Overley Intersect na elaboração dos produtos cartográficos. Os resultados evidenciaram em 2017, a existência de 20 áreas com 3.743 residências utilizando a fossa rudimentar na coleta dos esgotos. A sobreposição dos casos de diarreia e fossa rudimentar, identificou as áreas mais frágeis do ponto de vista sanitário. A espacialização delas permitiu a Vigilância em Saúde Ambiental e as Unidades de Saúde da Família, realizar visitas domiciliares com maior frequência. Essa ação visou a redução dos casos de diarreia identificadas no território estudado. A partir desses resultados, sugere-se a continuidade do monitoramento de cunho epidemiológico e ambiental e sua espacialização em todos os bairros da cidade de Natal, uma vez que a fragilidade sanitária identificada não é uma condição apenas do bairro Pajuçara.
VoTec
Authors: Yamamoto Márcio Issamu
Published: August 2020

O objetivo deste trabalho é apresentar um recorte da nossa pesquisa de Mestrado, conforme Yamamoto (2015), em que criamos um vocabulário terminológico bilíngue, português-inglês, de Linguística Histórica (LH), sob a metodologia e abordagem da Linguística de Corpus (LC). Teoricamente, este trabalho está embasado nos conceitos de vocabulário de Barbosa (1992), de Terminologia de Krieger e Finatto (2004), de contextos definitórios de Aubert (1996) e na Teoria Comunicativa da Terminologia de Cabré (1999). Do ponto de vista metodológico, selecionamos termos e elaboramos as definições deles a partir da análise de corpora constituídos de textos da área de LH. Os corpora caracterizaram-se por ser comparáveis e acadêmicos, compostos por teses, dissertações, artigos científicos e anais de eventos. A dimensão dos corpora totalizou aproximadamente um milhão de itens, dos quais 500 mil são de língua portuguesa e 500 mil são de língua inglesa. O software que usamos para o processamento dos dados linguísticos foi o WordSmith Tools versão 6.0 (SCOTT, 2012), e as ferramentas que utilizamos desse programa foram a lista de palavras, a lista de palavras-chave e o concordanciador. Construímos as definições seguindo o padrão gênero próximo, diferença específica (GPDE), com vistas a tradutores, estudantes e profissionais da área de Letras, Linguística e Tradução. Como resultado, o nosso vocabulário bilíngue de Linguística Histórica possui 26 termos, está disponibilizado na plataforma on-line denominada Vocabulário Técnico (VoTec), de Fromm (2007), sendo de acesso público e gratuito.
A identidade brasiliense na variação lexical da estrutura urbana do Plano Piloto
Authors: Maia Pires Flávia de Oliveira
Published: August 2020

Este trabalho é parte de um estudo sobre o léxico da estrutura urbana e arquitetônica do Plano Piloto de Brasília, no âmbito dos estudos lexicais e terminológicos. Identificou-se variações entre os itens lexicais que denominam a estrutura urbana e arquitetônica, utilizados pelos habitantes da capital do Brasil, revelando marcas identitárias do brasiliense em conversas cotidianas que envolvem a cidade. As variações lexicais englobam siglas, nomes complexos e nomes simples. A pesquisa demonstra que as variações estão sujeitas ao contexto de uso. Utilizou-se a metodologia analítica-descritiva. O corpus foi formado por textos especializados, textos de divulgação e sites governamentais sobre Brasília. A ferramenta AntConc (ANTHONY, 2019)  auxiliou no processamento dos dados. As bases para este trabalho foram a teoria da terminologia variacionista de Faulstich (1996, 1997, 1998 e 2001) e estudos de Maia-Pires (2009 e 2018). O primeiro estudo, incluindo as variações lexicais, registrou um conjunto de 216 nomes que compunham o léxico urbanístico do Plano Piloto, a etapa mais recente acrescentou 54 nomes, incluindo elementos arquitetônicos, formando um total de 270 itens lexicais que estão divulgados em um glossário, publicado em abril de 2018.
importância da poesia no desenvolvimento psíquico do estudante de nível médio
Authors: Andrade Fabíola Fernandes
Published: August 2020

Este artigo tem como objetivo refletir sobre a importância da poesia no desenvolvimento psíquico superior dos estudantes do ensino médio. Por meio de um levantamento bibliogr,áfico é realizada uma reflexão sobre a importância do professor como mediador no processo de ensino-aprendizagem e como a poesia é uma ferramenta importante para o desenvolvimento do estudante. As reflexões são norteadas por Calkins (1989), Bakhtin(2014), Leontiev(2014), Luria(1979,1996), Perrotti(1986) e Vygotsky (2007,2010). Posteriormente, é apresentada uma experiência em sala de aula do curso técnico de Eletroeletrônica do IFCE. Os estudantes sentiram-se motivados para a escrita de um discurso polifônico, aberto e multidirecionado que é a poesia. Compartilharam suas experiências, sentimentos e valores.
Atrial fibrillation and cognitive impairment: cerebral microbleeds as a new risk factor and possibilities of anticoagulant therapy (Part 2)
Authors: Ostroumova O. D. , Kochetkov A. I. , Ostroumova T. M.
Published: August 2020

Atrial fibrillation (AF) and cognitive impairment (CI) are among the most important problems of the modern health care system, which are characterized by an extremely high prevalence with the increasing trend of the latter; they lead to lower quality of life, shorter duration, and a larger number of disabled people. The specific feature of AF and CI is the presence of common risk factors. To date, the data of an increasing number of studies allow cerebral microbleeds (CMBs) to be considered as a new risk factor for CI, inter alia in patients with AF. In recent years, special attention has been paid to the role of oral anticoagulants (OACs) in the prevention of CI in AF, which is reflected in a number of studies and meta-analyses. In terms of the effect of OACs on the risk of CMBs, there is reason to believe that the latter increases with the use of warfarin, the effects of direct OACs (DOAC) in this regard require further investigation. At the same time, among the DOACs, apixaban is the only drug that has been proven to have no negative effect on the risk of CMBs in a randomized controlled clinical trial. In general, the available data indicate the positive effect of OACs in reducing the risk of CI and dementia in AF; moreover, DOACs have an advantage in this respect. Among the DOACs, apixaban is promising due to its optimal efficacy and safety profile.
Insomnia and cognitive behavioral therapy for chronic back pain
Authors: Parfenova E. V.
Published: August 2020

To manage patients with chronic back pain (CBP) is one of the urgent problems of modern medicine, as CBP is associated with high disability, considerable socioeconomic costs, and low quality of life. Concurrent disorders, such as insomnia, depression, and anxiety, which make a significant contribution to the severity of CBP and related disability, are frequently disregarded when managing patients with CBP. Insomnia is observed in the majority of patients with CBP, but it is relatively rarely diagnosed, therefore the bulk of patients do not receive appropriate treatment. Cognitive behavioral therapy (CBT) combined with therapeutic exercises is one of the most effective treatments in patients with CBP; moreover, of great importance is the identification of concomitant insomnia, whose treatment with CBT is able not only to improve sleep, but also to reduce pain and to increase the physical and social activities of patients. A positive combination treatment effect is achieved due to a change in the patients’ ideas about the prognosis and causes of the disease, as well as to the increased intensity of physical activity and to the prevention of strenuous exercise and static stresses.
Discogenic lumbosacral radiculopathy. Recommendations of the Russian Association for the Study of Pain (RSSP)
Authors: Parfenov V. A. , Yakhno N. N. , Davydov O. S. , Kukushkin M. L. , Churyukanov M. V. , Golovacheva V. A. , Evzikov G. Yu. , Isaikin A. I. , Ivanova M. A. , Karateev A. E. , Amelin A. V. , Achkasov E. E. , Akhmadeeva L. R. , Bakhtadze M. A. , Barantsevich E. R. , Barulin A. E. , Belova A. N. , Belskaya G. N. , Bychenko V. G. , Doronina O. B. , Dreval O. N. , Zagorulko O. I. , Isagulyan E. D. , Iskra D. A. , Kalinsky P. P. , Karakulova Yu. V. , Kurushina O. V. , Medvedeva L. A. , Merkulova D. M. , Rachin A. P. , Sergienko D. A. , Strokov I. A. , Khabirov F. A. , Shirokov V. A. , Yakupov E. Z.
Published: August 2020

When examining a patient with lumbosacral pain, it is necessary to rule out the specific cause of the disease. The diagnosis of discogenic lumbosacral radiculopathy (DLSR) is based on clinical examination; magnetic resonance imaging (MRI) is of informative value in excluding other causes of radiculopathy and in evaluating disk herniation. If the signs of cauda equina and spinal cord compression are absent, and no epidural glucocorticoid injection or urgent surgical treatment is scheduled, there is no reason for early (within the first 4 weeks) MRI.It is recommended to inform the patient with DLSR about the possibility of disk herniation regression and natural recovery and about the advisability of maintaining physical activity. Epidural administration of local anesthetics and glucocorticoids and use of non-steroidal anti-inflammatory drugs are advisable to relieve acute pain. Anticonvulsants (pregabalin and gabapentin), muscle relaxants, and B vitamins can be used as additional methods for acute DLSR; psychological therapies (cognitive behavioral therapy), antidepressants, therapeutic exercises (kinesiotherapy), manual therapy, and acupuncture are effective in chronic DLSR. Consultation with a neurosurgeon for possible microdiscectomy is indicated in the presence of cauda equina syndrome (urgently) and in the absence of medical therapy effects within 4–8 weeks.Therapeutic exercises (kinesitherapy) with an educational program for prevention of strenuous physical activity and static and uncomfortable positions for a long time, as well as for teaching how to lift weights properly, etc. are recommended for preventive purposes.
Experience with citicoline in patients with post-stroke cognitive impairment
Authors: Bogolepova A. N. , Burd S. G. , Lebedeva A. V. , Kovalenko E. A.
Published: August 2020

Objective: to investigate the efficacy and safety of citicoline (Ceresil® Canon) in patients with post-stroke cognitive impairment.

Patients and methods. Examinations were made in 33 patients aged 45 years and older who had experienced primary ischemic hemispheric stroke with complaints of a decline in memory or other cognitive functions. The cognitive status was assessed using the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA). The presence of anxiety-depressive spectrum disorders was determined on the Hospital Anxiety and Depression Scale. All the patients received citicoline (Ceresil® Canon) oral solution at a dose of 1000 mg/day for 3 months.

Results and discussion. Citicoline administration showed a statistically significant reduction in the severity of cognitive impairment (p<0.001). The time course of positive changes in the cognitive status of patients was reflected by an increase in the median score on the MMSE from 26 [25; 27.5] to 28 [26.5; 29] and on MoCA from 23 [21; 25] to 25 [22; 26]. There was a decline in the number of patients with anxiety-depressive disorders. No adverse events or side effects were found in the patients.

Conclusion. The findings suggest that citicoline (Ceresil® Canon) produced as an oral solution is well tolerated and improves cognitive functions and affective sphere in patients in the recovery period of ischemic stroke.
Depressions with eating disorders: clinical manifestations and therapy
Authors: Medvedev V. E. , Frolova V. I. , Gushanskaya E. V. , Fofanova Yu. S. , Martynov S. E. , Zuikova N. L. , Burno A. M. , Nekrasova S. V. , Salyntsev I. V.
Published: August 2020

Depression is a common comorbid diagnosis in patients with eating disorders (EDs). The development of pathogenetic therapy for depression with EDs is far from being completed.

The objective of the psychopharmacotherapeutic study was to evaluate the efficacy and tolerability of melatonergic monotherapy with the antidepressant agomelatine (25–50 mg/day at night) for depressions with two ED variants: hyperphagic (n=32) and hypo- and aphagic (n=31) EDs.

Patients and methods. The investigation enrolled patients of both sexes, aged 18 to 65 years. The investigators performed clinical psychopathological and experimental psychological studies, as well as psychometric examination using the 21-item Hamilton Depression Rating Scale (HDRS-21), the Clinical Global Impression (CGI), the Supplemental Hospital Offset Payment Program (SHOPP), the Dutch Eating Behavior Questionnaire (DEBQ), and statistical data processing.

Results and discussion. There was a significant pronounced antidepressant effect of 6-week agomelatine therapy for depressions occurring with different ED variants both in the pattern of the depressive symptom complex and in that of concurrent with and preceding the latter. At the same time, the efficacy of the drug did not depend on the clinical presentations of the leading hypothymic syndrome, the variants of EDs, and the duration of actual depression. However, by the end of the study period, a larger effect was achieved in the therapy for depressions with the hyperphagic variant of EDs, as well as in patients with EDs manifesting in the pattern of depressive symptom complex. Agomelatine has a favorable tolerance profile. BMI tends to become normal in patients with different variants of EDs during the therapy. The adverse events are transient and/or unclear; they do not require therapy discontinuation.

Conclusion. Agomelatine is an effective and relatively safe drug that can be recommended to treat depressions concurrent with EDs in therapeutic dosages for at least 6 weeks.
The main clinical and diagnostic characteristics of patients with low back pain and sacroiliac joint diseases (results of the IOLANTA-II study)
Authors: Zolotovskaya I. A. , Davydkin I. L.
Published: August 2020

Objective: to investigate the clinical and diagnostic characteristics of patients with low back pain in the presence of sacroiliac joint (SIJ) disease.

Patients and methods. The investigation design involved three visits: V 1 (inclusion); V 2 (after 7 days), and V 3 (after 3 months); after the screening period, the investigation enrolled 259 patients aged 65.5 [62.5; 69.5] years; of them there were 165 (63.7%) women. At V 1 , according to magnetic resonance imaging findings, the patients were divided into two groups: 1) 157 patients without confirmed SIJ disease; 2) 102 patients with confirmed SIJ disease. During all visits, the investigators made general clinical and neurological examinations and assessed the intensity of pain syndrome according to a visual analogue scale (VAS) for pain in millimeters, a neuropathic pain component according to the DN4 questionnaire, by determining the blood parameters: transforming growth factor-β1 (TGF-β1), interleukin-1β (IL-1β), IL-6, Beta-Crosslaps, the indicator of bone matrix formation procollagen type 1 N-terminal propeptide (P1NP) and by estimating the urinary level of deoxypyridinoline.

Results and discussion. At all visits, Group 2 patients with higher VAS pain scores had a pain history that was statistically significantly longer (p<0.001). The ANOVA analysis showed that the patients in Group 2 had statistically significantly higher values of TGF-β1, IL-1β, IL-6, and bone resorption markers than those in Group 1, which suggests the relationship between pain syndrome and the presence of an inflammatoryresorptive process in patients with SIJ disease.

Conclusion. A high (39.4%) prevalence of SIJ disease was noted in patients over 60 years of age with low back pain. During the follow-up period, there was a decrease in bone resorption markers and cytokines; however, the SIJ disease group showed less pronounced changes with statistically significant differences in all parameters than in the non-SIJ disease group. It is advisable to consider an algorithm for diagnosing a patient over 60 years of age with low back pain, by mandatorily examining his/her SIJ. Treatment policy, including methods for correction with drugs, should be discussed based on the findings.
Use of an image analyser to study the imbibition process of Melia dubia seeds
Authors: Satya Srii V. , Nethra N. , Umarani K. , Sowmya H. , Devaraju P.J.
Published: August 2020

An image analyser system was used to study the process of imbibition in Melia dubia seeds, and in comparison with the conventional method of measuring seed weight by an electronic balance. Melia dudia drupes were divided into three groups and treated accordingly: drupes with
intact pericarp, drupes with punctured pericarp and naked seeds without pericarp. Using seed weight and perimeter as parameters, the imbibition process in the seed samples were described by a series of imbibition curves illustrative of the triphasic pattern of water uptake during germination.
The image analyser captured small variation in seed parameters between the groups. The sensitivity and feasibility of the advanced method of using an image analyser to investigate individual seeds within a population imply that the image analyser has high potential in advancing seed biology
studies.
History of Inheritance of Wayang Topeng Malangan (Malang Traditional Mask Puppet) in Pakisaji and Tumpang
Authors: Wibowo Arining , Kurnain Joko , Juanda Juanda
Published: August 2020

This study aims to explain the history and process of inheriting mask puppet art in two representative hermitages (padepokan) (in Malang, namely Padepokan Asmoro Bangun in Pakisaji sub-district and Mangun Dharma in Tumpang sub-district). This research uses a qualitative approach. Data collection techniques are done through interviews, observation, and study documents. The process of inheritance includes art practices such as dancing, puppeteering, playing musical instruments, and making masks and transferring knowledge about Wayang Topeng Malangan. Inheritance is generally done since offsprings (children/grandchildren) are still at an early age. The history of the inheritance of the traditional mask puppet art in Padepokan Asmoro Bangun has occurred for six generations of this family since before 1930 starting from the Serun period. The sixth Padepokan Asmoro Bangun Heirs are two daughters named Winnie Padnecwara (15 years old) and Dita Andhika Raja Padmi (12 years old) who learned this art since the age of four. Padepokan Mangun Dharma is the home of mask puppet art, as well as music, traditional dance, and theatre, macapat, puppetry, and shadow puppets. The history of the inheritance of this hermitage began with the great-grandfather of the puppeteer Soleh namely Kek Sainten (Grandpa Sainten). The current heir of Padepokan Mangun Dharma is the son of the puppeteer Soleh, Supriyono Hadi Prasetyo, who also learned puppetry both autodidact and formally through college. Although inheritance occurs vertically, which is hereditary in each hermitage, horizontal inheritance also occurs between the two. This indicates that the inheritance process of Padepokan Asmoro Bangun and Mangun Dharma are related to each other.
Adaptation of The Wiruncana Murca Play in The Wayang Topeng Jatiduwur (Jatiduwur Mask Puppet) Jombang Performance
Authors: Yanuartuti Setyo , Juwariyah Anik , Puspito Peni , Winarko Joko
Published: August 2020

Wiruncana Murca play is the only Panji play in the Mask Puppet Performance in Jatiduwur Jombang which still performances its dramatic structure after the Mask Puppet is extinct. Wiruncana Murca play in the Wayang Topeng Jatiduwur Performance in the past was used for nadzar rituals. When the Mask Puppet was rebuilt, the Wiruncana Murca play was performed in a different context, the Panji Festival. This study aims to analyze the transformation process of the Wiruncana Murca play with an adaptation approach. The scope of this research includes text and context. The research method is descriptive qualitative analytical. The data collection used is observation, interview, and document study. The analysis uses an analytical descriptive method. The results performance that the adaptation of Wiruncana Murca in the Wayang Topeng Jatiduwur performance was carried out because there was a different contextuality from the ritual cultural context of the Jatiduwur village community to the context of the National Panji Festival performance in 2017 in Kediri. The transformation was carried out by the stages of identification of story ideas, the embodiment of the text, the embodiment of the dramaturgy, and staging. Adaptation to the process of intellectual transformation is based on a new contextual approach using fidelity or maintaining the originality of the source. The original uniqueness of the existing art is still used as a source of inspiration or a source of reference used as material to develop new performance products. The adaptation of the Wiruncana Murca play in the context of the Wayang Topeng Jatiduwur performance at the 2017 National Panji Festival performances the creative process of mask artists. While the result is a manifestation of a new product from Mask Puppet in Jatiduwur Jombang.
Professional Competence of Teachers in Learning Music at Elementary Schools in Pontianak
Authors: Ghozali Imam
Published: August 2020

Learning the art of music that has characteristics, special characters, and is carried out within an integrative thematic frame in elementary schools, needs to be supported by the professional competence of classroom teachers. The purpose of this study was to determine the professional competence of classroom teachers in learning music in elementary schools. This paper is the result of interpretive descriptive research with the main data source of classroom teachers, while the source of supporting data are students and principals. Data collection techniques are done by tests, observations, and interviews. The data collection process is carried out starting before the learning stage until the learning evaluation process. Based on the results of the study showed that: (1) the average mastery of classroom teachers to the knowledge of music theory needed in learning has only reached 45%; (2) the average teacher mastery of musical basic competencies has only reached 42.5%; and (3) the average teacher mastery of musical instrument playing skills competencies needed in learning has only reached 33.75%. The results of tests conducted on the teachers turned out to be relevant to the data obtained during the implementation of learning. It was proven that learning material in the form of musical knowledge such as music symbols, time bars, and various tempos is only taught by one class teacher. The practice of singing traditional songs is not supported by the teacher’s ability to give examples of reading song notation in accordance with the demands of the teacher’s handbook. Practical learning material for playing musical instruments is also only implemented by one classroom teacher. The implementation of music art learning in which most of the time allocation is filled with singing songs that are mastered (memorized) by the teacher. This shows that the classroom teacher in the implementation of music art learning has not been supported by adequate professional competence.
The Song of Macapat Semarangan: The Acculturation of Javanese and Islamic Culture
Authors: Cahyono Agus , Widodo Widodo , Jazuli Muhamad , Murtiyoso Onang
Published: August 2020

The research objective is to explain the macapat Semarangan song which is the result of acculturation of Javanese and Islamic culture. The study used qualitative methods by uncovering the concept of processing of Javanese music and acculturation. Research location was in Semarang with the object of macapat Semarangan song study. Data was collected through interviews, observations, and study documents. The validity of the data was examined through triangulation techniques and the analysis is done through the stages of identification, classification, comparison, interpretation, reduction, verification, and making conclusions. The results showed that the macapat Semarangan song has unique characteristics of arrangement. The song’s grooves use long and complicated musical ornamentations with varying pitch heights to reach high notes. This is a manifestation of the results of acculturation of Javanese and Islamic culture seen from arrangement on the parts of Adzan (call to prayer) and tilawatil Qur’an. The process of acculturation of elements of Islamic culture also involves scales. Azan songs use diatonic scales, some macapat Semarangan songs also use the same scales, but a cycle of five notes close to nuances of Chinese music scales. Various elements of arrangement on the Azan, Chinese and European musical scales then formed a new culture, macapat Semarangan.
Disponibilidad de productos agropecuarios de la Feria del Agricultor de San Ramón, Alajuela, Costa Rica
Authors: Sánchez-Brenes Ronald , Arboleda-Julio Esteban
Published: August 2020

Las ferias del agricultor costarricenses son centros de distribución y abastecimiento de productos agropecuarios, los cuales pueden contribuir a la seguridad alimentaria y nutricional de Costa Rica. En la presente investigación se planteó medir la disponibilidad, estacionalidad y frecuencia de los productos agropecuarios de la Feria del Agricultor de San Ramón (FASR), con el fin de que la FASR pueda ofrecer la disponibilidad física de los alimentos a su público consumidor. Se registraron un total de 165 productos agropecuarios en los tramos de comercialización, en un periodo de un año (noviembre 2015-octubre 2016). De la totalidad de productos agropecuarios observados, 35 % corresponde a frutas, 21 % a hortalizas o verduras, 21 % a plantas medicinales y aromáticas, 9 % a raíces feculentas y otros alimentos con alto contenido de carbohidratos, 7 % a productos de origen animal, 4 % a legumbres y   3 % a otros.