bluuebunny/crossref_metadata_2025 huggingface dataset:
Would you be impressed: applying principles of magic to chatbot conversations
Authors: Siskind Sarah Rose , Nichols Eric , Gomez Randy
Published: April 2024

A magician’s trick and a chatbot conversation have something in common: most of their audiences do not know how they work. Both are also constrained by their own limitations: magicians by the constraints of biology and physics, and dialogue systems by the status of current technology. Magicians and chatbot creators also share a goal: they want to engage their audience. But magicians, unlike the designers of dialogue systems, have centuries of practice in gracefully skirting limitations in order to engage their audience and enhance a sense of awe. In this paper, we look at these practices and identify several key principles of magic and psychology to apply to conversations between chatbots and humans. We formulate a model of communication centered on controlling the user’s attention, expectations, decisions, and memory based on examples from the history of magic. We apply these magic principles to real-world conversations between humans and a social robot and evaluate their effectiveness in a Magical conversation setting compared to a Control conversation that does not incorporate magic principles. We find that human evaluators preferred interactions that incorporated magical principles over interactions that did not. In particular, magical interactions increased 1) the personalization of experience, 2) user engagement, and 3) character likability. Firstly, the magical experience was “personalized.” According to survey results, the magical conversation demonstrated a statistically significant increase in “emotional connection” and “robot familiarity.” Therefore, the personalization of the experience leads to higher levels of perceived impressiveness and emotional connection. Secondly, in the Magical conversation, we find that the human interlocutor is perceived to have statistically-significantly higher engagement levels in four of seven characteristics. Thirdly, participants judged the robot in the magical conversation to have a significantly greater degree of “energeticness,”“humorousness,” and “interestingness.” Finally, evaluation of the conversations with questions intended to measure contribution of the magical principals showed statistically-significant differences for five out of nine principles, indicating a positive contribution of the magical principles to the perceived conversation experience. Overall, our evaluation demonstrates that the psychological principles underlying a magician’s showmanship can be applied to the design of conversational systems to achieve more personalized, engaging, and fun interactions.
Molecular commensalism: how oral corynebacteria and their extracellular membrane vesicles shape microbiome interactions
Authors: Kreth Jens , Helliwell Emily , Treerat Puthayalai , Merritt Justin
Published: April 2024

Historically, the study of microbe-associated diseases has focused primarily on pathogens, guided by Koch's postulates. This pathogen-centric view has provided a mechanistic understanding of disease etiology and microbial pathogenesis. However, next-generation sequencing approaches have revealed a far more nuanced view of the roles various microbes play in disease, highlighting the importance of microbial diversity beyond individual pathogens. This broader perspective acknowledges the roles of host and microbial communities in disease development and resistance. In particular, the concept of dysbiosis, especially within the oral cavity, has gained attention for explaining the emergence of complex polymicrobial diseases. Such diseases often stem from resident microbes rather than foreign pathogens, complicating their treatment and even clouding our understanding of disease etiology. Oral health is maintained through a delicate balance between commensal microbes and the host, with diseases like caries and periodontal disease arising from pathogenic perturbations of this balance. Commensal microbes, such as certain streptococci and Corynebacterium spp., play crucial roles in maintaining oral health through mechanisms involving hydrogen peroxide production and membrane vesicle secretion, which can inhibit pathogenic species and modulate host immune responses. Recent research focused upon the mechanisms of molecular commensalism has expanded our understanding of these key functions of the commensal microbiome, demonstrating their central role in promoting oral health and preventing disease. These abilities represent a largely untapped reservoir of potential innovative strategies for disease prevention and management, emphasizing the need to bolster a symbiotic microbiome that inherently suppresses pathogenesis.
Blue Carbon Ecosystems: Ocean Heroes in the Fight Against Climate Change
Authors: Macreadie Peter I. , Costa Micheli D. P. , Atwood Trisha B. , Friess Daniel A. , Kelleway Jeffrey J. , Kennedy Hilary , Lovelock Catherine E. , Serrano Oscar , Davey Tallulah , Duarte Carlos M.
Published: April 2024

Our planet is facing a critical challenge: climate change. This is caused by human activities that release carbon dioxide and other greenhouse gases into Earth’s atmosphere. As temperatures rise and weather becomes more extreme, scientists are searching for solutions. Blue carbon ecosystems could be part of the answer! These ecosystems include mangrove forests, tidal marshes, and seagrass meadows—ocean and coastal ecosystems that capture and store carbon, keeping it out of the atmosphere. In our research, we found that these ecosystems cover a huge area of Earth’s surface, up to the size of Mexico. They store a whopping 30 billion tons of carbon, which is huge! If we stop destroying blue carbon ecosystems and restore the ones we have lost, it could balance out 3% of the greenhouse gases we put into the atmosphere. Pretty important, right! Overall, blue carbon ecosystems are nature’s heroes in the fight against climate change.
Meso-institutions shaping arenas for policymaking: an exploratory study on front-of-package food labelling in Brazil, Chile, and Mexico
Authors: Guerreiro Felipe Jannuzzi , Vinholis Marcela de Mello Brandão , Nunes Rubens , Silva Vivian Lara
Published: April 2024

Front-of-package food labelling (FOPL) is a mechanism to inform consumers on food nutrients content and risks for health. Each country, within its own institutional framework, defines methods and protocols to formulate rules capable of influencing organizations and the behavior of agents. The paper aims at evaluating the role of some meso-institutions in shaping arenas for policymaking on FOPL based on an exploratory study in Brazil, Chile, and Mexico. A documental analysis and literature review were employed, followed by in-depth interviews. The relevant aspects of FOPL assessed were thresholds for sugar, fats, and sodium; marketing restrictions, and timeframe given for compliance with the new rules. The contribution of this article is to illuminate the way in which meso-institutions operate in a specific context, namely the development of food labelling standards. The focus is to find the rules that allowed the participation of stakeholders in the process of defining normative acts intended to regulate food labelling. The discussion of mandatory FOPL can be interpreted as a struggle to define proper rights for the food industry and the consumer. Meso-institutions, as translators of general normative principles in specific contexts, can encourage or restrict stakeholder participation in policymaking. Besides political arena, the participation can be done in other arenas, such as legislature, regulatory agencies, scientific community, media and public opinion. Institutions that encourage stakeholder participation increase the probability of obtaining widely accepted specific rules.
Longitudinal patterns of companion animals in families with children during the COVID-19 pandemic: Findings from the Adolescent Brain Cognitive Development (ABCD) Study®
Authors: King Erin K. , Dowling-Guyer Seana , McCobb Emily , Mueller Megan K.
Published: April 2024

Pet acquisition purportedly increased during the COVID-19 pandemic with individuals acquiring pets during periods of social isolation. Families with children experienced unique challenges during the COVID-19 pandemic, balancing childcare, remote schooling, and other needs and therefore patterns of pet acquisition and loss may differ from the broader population. The goal of this study was to understand patterns of pet ownership within families with adolescents during the pandemic to help identify areas for improved support and programmatic recommendations. Using self-reported survey data from a sample of 7,590 American adolescents from the Adolescent Brain Cognitive Development (ABCD) Study® COVID Survey, we found no evidence for large-scale changes in pet acquisition or relinquishment during the first year of the pandemic for families with adolescents in the U.S. Future research should explore the effects of pet acquisition and pet loss on families with adolescents and what resources are needed to support pet ownership during stressors such as the COVID-19 pandemic.
Prevalence of Musculoskeletal and Metabolic Disorders in Kidney Transplant Recipients: A Systematic Review and Meta-Analysis
Authors: Herreros-Carretero Álvaro , Berlanga-Macías Carlos , Martínez-Vizcaíno Vicente , Torres-Costoso Ana , Pascual-Morena Carlos , Hernández-Castillejo Luis Enrique , Sequí-Domínguez Irene , Garrido-Miguel Miriam
Published: April 2024

Introduction:

Musculoskeletal disorders could be associated with metabolic disorders that are common after kidney transplantation, which could reduce the quality of life of patients. The aim of this study was to assess the prevalence of both musculoskeletal and metabolic disorders in kidney transplant patients.

Methods:

MEDLINE, CINAHL, Cochrane Library, EMBASE and Web of Science were searched from their inception up to June 2023. DerSimonian and Laird random-effects method was used to calculate pooled prevalence estimates and their 95% confidence intervals (CIs).

Results:

21,879 kidney transplant recipients from 38 studies were analysed. The overall proportion of kidney transplant patients with musculoskeletal disorders was 27.2% (95% CI: 18.4–36.0), with low muscle strength (64.5%; 95% CI: 43.1–81.3) being the most common disorder. Otherwise, the overall proportion of kidney transplant patients with metabolic disorders was 37.6% (95% CI: 21.9–53.2), with hypovitaminosis D (81.8%; 95% CI: 67.2–90.8) being the most prevalent disorder.

Conclusion:

The most common musculoskeletal disorders were low muscle strength, femoral osteopenia, and low muscle mass. Hypovitaminosis D, hyperparathyroidism, and hyperuricemia were also the most common metabolic disorders. These disorders could be associated with poorer quality of life in kidney transplant recipients.

Systematic Review Registration:

https://www.crd.york.ac.uk/prospero/, identifier [CRD42023449171].
Weight Adjustment Framework for Self-Attention Sequential Recommendation
Authors: Su Zheng-Ang , Zhang Juan
Published: April 2024

In recent years, sequential recommendation systems have become a hot topic in the field of recommendation system research. These systems predict future user actions or preferences by analyzing their historical interaction sequences, such as browsing history and purchase records, and then recommend items that users may be interested in. Among various sequential recommendation algorithms, those based on the Transformer model have become a focus of research due to their powerful self-attention mechanisms. However, one of the main challenges faced by sequential recommendation systems is the noise present in the input data, such as erroneous clicks and incidental browsing. This noise can disrupt the model’s accurate allocation of attention weights, thereby affecting the accuracy and personalization of the recommendation results. To address this issue, we propose a novel method named “weight adjustment framework for self-attention sequential recommendation” (WAF-SR). WAF-SR mitigates the negative impact of noise on the accuracy of the attention layer weight distribution by improving the quality of the input data. Furthermore, WAF-SR enhances the model’s understanding of user behavior by simulating the uncertainty of user preferences, allowing for a more precise distribution of attention weights during the training process. Finally, a series of experiments demonstrate the effectiveness of the WAF-SR in enhancing the performance of sequential recommendation systems.
Investigating the Effect of Processing and Material Parameters of Alginate Dialdehyde-Gelatin (ADA-GEL)-Based Hydrogels on Stiffness by XGB Machine Learning Model
Authors: Ege Duygu , Boccaccini Aldo R.
Published: April 2024

To address the limitations of alginate and gelatin as separate hydrogels, partially oxidized alginate, alginate dialdehyde (ADA), is usually combined with gelatin to prepare ADA-GEL hydrogels. These hydrogels offer tunable properties, controllable degradation, and suitable stiffness for 3D bioprinting and tissue engineering applications. Several processing variables affect the final properties of the hydrogel, including degree of oxidation, gelatin content and type of crosslinking agent. In addition, in 3D-printed structures, pore size and the possible addition of a filler to make a hydrogel composite also affect the final physical and biological properties. This study utilized datasets from 13 research papers, encompassing 33 unique combinations of ADA concentration, gelatin concentration, CaCl2 and microbial transglutaminase (mTG) concentrations (as crosslinkers), pore size, bioactive glass (BG) filler content, and one identified target property of the hydrogels, stiffness, utilizing the Extreme Boost (XGB) machine learning algorithm to create a predictive model for understanding the combined influence of these parameters on hydrogel stiffness. The stiffness of ADA-GEL hydrogels is notably affected by the ADA to GEL ratio, and higher gelatin content for different ADA gel concentrations weakens the scaffold, likely due to the presence of unbound gelatin. Pore size and the inclusion of a BG particulate filler also have a significant impact on stiffness; smaller pore sizes and higher BG content lead to increased stiffness. The optimization of ADA-GEL composition and the inclusion of BG fillers are key determinants to tailor the stiffness of these 3D printed hydrogels, as found by the analysis of the available data.
Pediatric Lower Urinary Tract Dysfunction: A Comprehensive Exploration of Clinical Implications and Diagnostic Strategies
Authors: Kopač Matjaž
Published: April 2024

Lower urinary tract dysfunction is clinically important because it may cause urinary tract infections, mainly due to accumulation of residual urine, and adversely affect renal function. In addition, it may cause urinary incontinence, strongly affecting the child’s quality of life. The function of the lower urinary tract is closely associated with function of the bowel because constipation is commonly present with bladder dysfunction. The interplay between the lower urinary tract and bowel function, coupled with common conditions such as detrusor overactivity and voiding dysfunction, requires a nuanced diagnostic approach. Detrusor overactivity, a benign but socially harmful condition, is the principal cause of daytime urinary incontinence in childhood. It needs to be differentiated from more serious conditions such as neurogenic bladder dysfunction or urethral obstruction. Voiding dysfunction, a habitual sphincter contraction during voiding, is common in children with detrusor overactivity and may be self limiting but may also result in residual urine and urinary tract infections. It may resemble, in severe cases, neurogenic bladder dysfunction, most often caused by spinal dysraphism, which very often leads to recurrent urinary tract infections and high intravesical pressures, jeopardizing renal function. A voiding diary is crucial in the initial evaluation of lower urinary tract function in children.
Dynamic 3D Point-Cloud-Driven Autonomous Hierarchical Path Planning for Quadruped Robots
Authors: Zhang Qi , Li Ruiya , Sun Jubiao , Wei Li , Huang Jun , Tan Yuegang
Published: April 2024

Aiming at effectively generating safe and reliable motion paths for quadruped robots, a hierarchical path planning approach driven by dynamic 3D point clouds is proposed in this article. The developed path planning model is essentially constituted of two layers: a global path planning layer, and a local path planning layer. At the global path planning layer, a new method is proposed for calculating the terrain potential field based on point cloud height segmentation. Variable step size is employed to improve the path smoothness. At the local path planning layer, a real-time prediction method for potential collision areas and a strategy for temporary target point selection are developed. Quadruped robot experiments were carried out in an outdoor complex environment. The experimental results verified that, for global path planning, the smoothness of the path is improved and the complexity of the passing ground is reduced. The effective step size is increased by a maximum of 13.4 times, and the number of iterations is decreased by up to 1/6, compared with the traditional fixed step size planning algorithm. For local path planning, the path length is shortened by 20%, and more efficient dynamic obstacle avoidance and more stable velocity planning are achieved by using the improved dynamic window approach (DWA).
Multi-Parameter Experimental Research on the Expansion Force Affecting Lime-Sand Piles under Preloading Pressure
Authors: Qiao Yong , Si Jianhui , Yuan Jia , Wang Yi , Niu Xiaoyu , Ju Junpeng , Zhou Ming , He Lizhe
Published: April 2024

Aiming at the problems that it is difficult to control the expansion force of lime-sand pile in the foundation correcting and how the upper existing structural pressure affects the expansion force of lime-sand pile, this paper adopts a new type of lime-sand pile reaction tester to carry out the experimental research on the expansion force of lime-sand pile under the influences of different pre-pressure, different mixing ratios, different heights, and different granular sizes. The purpose of this paper is to explore the influence of the pre-pressure brought by the existing building structure on the expansion force of the lime-sand pile and the coupling effect of the pre-pressure and other influencing factors on the expansion force of the lime-sand pile through the multi-parameter test. The results show that with the increase in pre-pressure, the expansion force of the lime-sand pile shows the trend of increasing first and then decreasing when the pre-pressure is 0.88 KN, the effect is most obvious and its expansion force can be increased by 14.9%. Within a certain range, the larger the proportion of quicklime is, the lower the expansion reaction force is. The expansion force of the lime-sand pile with the ratio of lime/sand/soil of 5:4:1 is the most ideal, and its value reaches 10.2 KN, which is 10% and 15.3% higher than the rest of the two groups, respectively. Within a certain range, the effect of specimen height change on the expansion force of the lime-sand pile is almost negligible. The smaller particle size of quicklime makes its reaction speed faster, the reaction degree is more full, and the expansion force is greater. The expansion force of the small particle size group was 12.1% and 34.2% higher than that of the medium and large particle size groups, respectively.
Utilizing Metal Oxide Thin Films for Device Engineering of Solution-Processed Organic Multi-Junction Solar Cells
Authors: Hadipour Afshin
Published: April 2024

Electron and hole transporting layers play a major role in high-performance and stable organic-based optoelectronic devices. This paper demonstrates detailed device engineering of multi-junction organic photovoltaics built on two different metal oxide-based electron and hole transport (buffer) layers prepared by thermal or solution-processed methods. The main focus is on the device processing parameters as well as practical details of preparation of buffer layers to give the research community a clear, step-by-step recipe to successfully replicate and build series and parallel connected multi-junction solution-based organic solar cells for their needs. Here, the recipes and deposition conditions of two metal oxide buffer layers are presented in detail, based on basic commercially available materials and tools, to achieve well-engineered tandem (multi-junction) solution-processed organic solar cells. The buffer layers have appropriate energy levels for electrical selectivity of anode and cathode electrodes, and they are highly stable and chemically compatible with processing of solution-based polymer solar cells. To demonstrate the engineering steps of multi-junction devices, the PCE10:PC70BM blend is used as the active layer for all subcells. Then, to improve the power conversion efficiency of the single-junction photovoltaic device, PCE10:PC70BM blend is used in combination with DPPx:PC70BM with different absorption spectra for bottom and top subcell active layers. An optimized series tandem device with 10.6% power conversion efficiency is demonstrated. Generally, the device structures reported here can also be used for other types of optoelectronic devices, such as light emitting diodes and photodetectors.
We Have Met the Enemy in Teacher Education; It Is Us—Teacher Educators and the Bad Faith of Our Niceness, Not Teachers
Authors: Harris Brenda G.
Published: April 2024

In this conceptual essay, the author draws on the concept of bad faith to explore its connections to Niceness and role in sustaining the historical failures of U.S. teacher education to prepare future teachers to effectively teach learners from diverse backgrounds through culturally responsive pedagogy. Bad faith is a useful, albeit underutilized, concept in considering and challenging the patterned historical inequities maintained by Niceness in teacher preparation programs. Applying a critical race theory (CRT) methodology and analysis, the author presents and interrogates three representative exemplars of a logic of racism operationalized through bad faith, then insulated by Niceness in U.S. teacher education. These exemplars serve as conceptual case studies that are constituted as composite scenarios of patterned enactments of bad faith authorized by Niceness within U.S. teacher education; these cases demonstrate how [and why] the bad faith–Niceness interplay informs the work and [good] intentions of stakeholders most often in ways that further, rather than challenge, historical failures of U.S. teacher education for culturally responsive pedagogy.
Evaluating the Ceiling Gas Temperature in a Branched Tunnel Fire with a Sloped Mainline Region under Natural Ventilation
Authors: Lu Ning , Yao Xiaolin , Yang Jinming , Huang Youbo
Published: April 2024

The effect of the mainline slope on the ceiling temperature profile in a branched tunnel has not been clarified nor included in existing models. Thus, in this paper, the numerical code was employed to investigate the induced airflow velocity and gas temperature beneath the ceiling in a branch tunnel with a sloped upstream mainline. The mainline slope varied from 1% to 7%, with an interval of 1%. Five fire power of 3 MW, 5 MW, 10 MW, 15 MW, and 20 MW are employed on each slope. The airflow velocity and the longitudinal temperature in the mainline tunnel are measured and analyzed. Results show that the stack effect obviously occurred, which caused longitudinal velocity to prevent the smoke reverse flow in the mainline. The induced airflow velocity in the upstream inclined mainline is higher with increasing slope, and the dimensionless velocity is normalized well by the proposed expression. The maximum ceiling temperature is independent of the mainline slope and correlated well by Q*2/3, but the effect of the mainline slope on temperature longitudinal decay is worth considering. Finally, a normalized expression for longitudinal temperature decay in an inclined mainline is proposed by taking the fire power and mainline slope into account.
Impressive Exact Solitons to the Space-Time Fractional Mathematical Physics Model via an Effective Method
Authors: Alsharidi Abdulaziz Khalid , Junjua Moin-ud-Din
Published: April 2024

A new class of truncated M-fractional exact soliton solutions for a mathematical physics model known as a truncated M-fractional (1+1)-dimensional nonlinear modified mixed-KdV model are achieved. We obtain these solutions by using a modified extended direct algebraic method. The obtained results consist of trigonometric, hyperbolic trigonometric and mixed functions. We also discuss the effect of fractional order derivative. To validate our results, we utilized the Mathematica software. Additionally, we depict some of the obtained kink, periodic, singular, and kink-singular wave solitons, using two and three dimensional graphs. The obtained results are useful in the fields of fluid dynamics, nonlinear optics, ocean engineering and others. Furthermore, these employed techniques are not only straightforward, but also highly effective when used to solve non-linear fractional partial differential equations (FPDEs).
Copper-Chelated Chitosan Microgels for the Selective Enrichment of Small Cationic Peptides
Authors: Jacquier Jean-Christophe , Duffy Ciara , O’Sullivan Michael , Dillon Eugène
Published: April 2024

Copper-chelated chitosan microgels were investigated as an immobilized metal affinity chromatography (IMAC) phase for peptide separation. The copper-crosslinked chitosan beads were shown to strongly interact with a range of amino acids, in a wide range of pH and saline conditions. The beads exhibited an affinity that seemed to depend on the isoelectric point of the amino acid, with the extent of uptake increasing with decreasing isoelectric point. This selective interaction with anionic amino acids resulted in a significant relative enrichment of the supernatant solution in cationic amino acids. The beads were then studied as a novel fractionation system for complex milk hydrolysates. The copper chitosan beads selectively removed larger peptides from the hydrolysate aqueous solution, yielding a solution relatively enriched in medium and smaller peptides, which was characterized both quantitatively and qualitatively by size exclusion chromatography (SEC). Liquid chromatography–mass spectrometry (LCMS) work provided comprehensive data on a peptide sequence level and showed that a depletion of the anionic peptides by the beads resulted in a relative enrichment of the cationic peptides in the supernatant solution. It could be concluded that after fractionation a dramatic relative enrichment in respect to small- and medium-sized cationic peptides in the solution, characteristics that have been linked to bioactivities, such as anti-microbial and cell-penetrating properties. The results demonstrate the use of the chitosan copper gel bead system in lab scale fractionation of complex hydrolysate mixtures, with the potential to enhance milk hydrolysate bioactivity.
To Speak with the Other—To Let the Other Speak: Paul Celan’s Poetry and the Hermeneutical Challenge of Mitsprechen
Authors: Richter Alexandra
Published: April 2024

This essay explores the notion of Mitsprechen or “with-speaking” in Paul Celan’s poetry. “With-speaking” supposes that voices in the poems actively participate and engage in a dialogue that goes beyond traditional hermeneutic frameworks. Celan’s notion of col-loquy, distinct from the conventional sense of dialogue, challenges the separation between author and interpreter, rendering the traditional concept of intertextuality inadequate. The poems, according to Celan, give voice to human destinies, making texts audible as the voices of others. This vocal dimension of Celan’s poetry has prompted extensive discussion among philosophers, particularly in France. Levinas, Blanchot, and Derrida, influenced by German phenomenology and hermeneutics, critically examine the ethical implications of speaking “about” the other. They challenge traditional hermeneutical practices, emphasizing the responsibility of interpreters to respect the unique and untranslatable character of individual voices. This critique extends to Protestant categories of interpretation, drawing on alternative Jewish perspectives on being-in-the-world and alterity. The text explores the tensions inherent in speaking “for” or “in the name of” others, especially in the context of interpreting Celan’s work, raising questions about maintaining the fundamental difference and distance that otherness implies. The discussion concludes by highlighting Werner Hamacher’s formulation of a new philology that disrupts hermeneutical violence, influenced by the critiques of Blanchot, Levinas, and Derrida, and offering an alternative way of addressing the particular challenges posed by Celan’s poetry.
The Application of Metal–Organic Frameworks in Water Treatment and Their Large-Scale Preparation: A Review
Authors: Xie Yuhang , Zhang Teng , Wang Bo , Wang Wenju
Published: April 2024

Over the last few decades, there has been a growing discourse surrounding environmental and health issues stemming from drinking water and the discharge of effluents into the environment. The rapid advancement of various sewage treatment methodologies has prompted a thorough exploration of promising materials to capitalize on their benefits. Metal–organic frameworks (MOFs), as porous materials, have garnered considerable attention from researchers in recent years. These materials boast exceptional properties: unparalleled porosity, expansive specific surface areas, unique electronic characteristics including semi-conductivity, and a versatile affinity for organic molecules. These attributes have fueled a spike in research activity. This paper reviews the current MOF-based wastewater removal technologies, including separation, catalysis, and related pollutant monitoring methods, and briefly introduces the basic mechanism of some methods. The scale production problems faced by MOF in water treatment applications are evaluated, and two pioneering methods for MOF mass production are highlighted. In closing, we propose targeted recommendations and future perspectives to navigate the challenges of MOF implementation in water purification, enhancing the efficiency of material synthesis for environmental stewardship.
A Novel Magnetic Nano-Adsorbent Functionalized with Green Tea Extract and Magnesium Oxide to Remove Methylene Blue from Aqueous Solutions: Synthesis, Characterization, and Adsorption Behavior
Authors: Lin Wenchao , Huang Yaoyao , Liu Shuang , Ding Wei , Li Hong , Zheng Huaili
Published: April 2024

In this study, a novel green tea/Mg-functionalized magnetic nano-adsorbent, denoted as GTE-MgO-Fe3O4 NPs, was developed and applied to the extraction of Methylene Blue (MB) from water-based solutions. The GTE-MgO-Fe3O4 NPs were synthesized by incorporating green tea extracts (GTE) and Mg species onto the surface of Fe3O4 nanoparticles using a hydrothermal method. Characterization analyses corroborated the successful functionalization of the Fe3O4 surface with GTE and Mg species, resulting in a superparamagnetic adsorbent equipped with abundant surface functional groups, which promoted MB adsorption and facilitated magnetic separation. Batch experiments revealed that different operating parameters had an impact on the adsorption behavior, such as adsorbent dosage, pH, coexisting ions, contact time, the initial MB concentration, and temperature. The investigations of adsorption kinetics and isotherms emphasized that the MB adsorption onto GTE-MgO-Fe3O4 NPs was an exothermic process dominated by chemisorption. The experimental adsorption capacity of GTE-MgO-Fe3O4 NPs for MB surpassed 174.93 mg g−1, markedly superior to the performance of numerous other adsorbents. Ultimately, the utilized GTE-MgO-Fe3O4 NPs could be effectively regenerated through acid pickling, retaining over 76% of its original adsorption capacity after six adsorption–desorption cycles, which suggested that GTE-MgO-Fe3O4 NPs was a suitable adsorbent for eliminating MB from effluent.
Simulation of Temperature Field in Steel Billets during Reheating in Pusher-Type Furnace by Meshless Method
Authors: Liu Qingguo , Hanoglu Umut , Rek Zlatko , Šarler Božidar
Published: April 2024

Using a meshless method, a simulation of steel billets in a pusher-type reheating furnace is carried out for the first time. The simulation represents an affordable way to replace the measurements. The heat transfer from the billets with convection and radiation is considered. Inside each of the billets, the heat diffusion equation is solved on a two-dimensional central slice of the billet. The diffusion equation is solved in a strong form by the Local Radial Basis Function Collocation Method (LRBFCM) with explicit time-stepping. The ray tracing procedure solves the radiation, where the view factors are computed with the Monte Carlo method. The changing number of billets in the furnace at the start and the end of the loading and unloading of the furnace is considered. A sensitivity study on billets’ temperature evolution is performed as a function of a different number of rays used in the Monte Carlo method, different stopping times of the billets in the furnace, and different spacing between the billets. The temperature field simulation is also essential for automatically optimizing the furnace’s productivity, energy consumption, and the billet’s quality. For the first time, the LRBFCM is successfully demonstrated for solving such a complex industrial problem.
Impact of Age on Long-Term Outcomes of Laparoscopic Nissen Fundoplication—A Single Center Study
Authors: Dowgiałło-Gornowicz Natalia , Kacperczyk Justyna , Masiewicz Anna , Osowiecka Karolina , Lech Paweł
Published: April 2024

Background and objectives: Gastroesophageal reflux disease (GERD) is a common disease affecting approximately 20% of the adult population. This study aimed to compare the results of laparoscopic Nissen fundoplication (LNF) in the treatment of GERD in patients of different age groups. Materials and Methods: A retrospective analysis was performed on patients who underwent LNF in one surgical department between 2014 and 2018. Patients were divided into three groups based on age: under 40 years of age, 40–65 years of age, and over 65 years of age. Results: A total of 111 patients (44.1% women) were analyzed in this study. The mean age was 50.2 ±15 years, and the mean follow-up was 50 months ± 16.6 months. Recurrence of symptoms occurred in 23%, 20%, and 23% in each age group, respectively (p = 0.13), and 85%, 89%, and 80% of patients from the respective groups reported that they would recommend the surgery to their relatives (p = 0.66). Furthermore, 83%, 92%, and 73% of patients from the respective age groups reported that they would undergo the surgery again with the knowledge they now had (p = 0.16). Conclusions: Given these results and observations, LNF has been shown to be a good method of treatment for GERD in every age group. In our study, there were no differences found in terms of satisfaction with surgery and associated recommendations between the studied age groups.
Multiparametric Mapping via Cardiovascular Magnetic Resonance in the Risk Stratification of Ventricular Arrhythmias and Sudden Cardiac Death
Authors: Lo Monaco Maria , Stankowski Kamil , Figliozzi Stefano , Nicoli Flavia , Scialò Vincenzo , Gad Alessandro , Lisi Costanza , Marchini Federico , Dellino Carlo Maria , Mollace Rocco , Catapano Federica , Stefanini Giulio Giuseppe , Monti Lorenzo , Condorelli Gianluigi , Bertella Erika , Francone Marco
Published: April 2024

Risk stratification for malignant ventricular arrhythmias and sudden cardiac death is a daunting task for physicians in daily practice. Multiparametric mapping sequences obtained via cardiovascular magnetic resonance imaging can improve the risk stratification for malignant ventricular arrhythmias by unveiling the presence of pathophysiological pro-arrhythmogenic processes. However, their employment in clinical practice is still restricted. The present review explores the current evidence supporting the association between mapping abnormalities and the risk of ventricular arrhythmias in several cardiovascular diseases. The key message is that further clinical studies are needed to test the additional value of mapping techniques beyond conventional cardiovascular magnetic resonance imaging for selecting patients eligible for an implantable cardioverter defibrillator.
Renal Embolism Associated with the Atrial Myxoma: A Case Report and Literature Review
Authors: Sega Masatoshi , Yamashita Marina , Maruyama Hiroshi , Taya Yuji , Ohgi Kentaro , Haraoka Rei , Hirayama Kouichi
Published: April 2024

Renal embolisms due to cardiac myxomas are extremely rare; the clinical course, treatment, and prognosis of this disease are not established. A 69-year-old Japanese woman who underwent a nephrectomy for renal cell carcinoma 3 years earlier was hospitalized with a right occipital lobe cerebral infarction. Her renal function suddenly worsened 3 days post-admission: her serum creatinine rose from 1.46 mg/dL to 6.57 mg/dL and then to 8.03 mg/dL the next day, and hemodialysis therapy was started. Abdominal computed tomography (CT) scans showed patchy non-contrasted low-density areas in the right kidney, and chest CT scans and transesophageal ultrasonography revealed a left atrial tumor. We diagnosed renal infarction due to a left atrial myxoma. Hemodialysis and anticoagulant therapy (heparin) were continued, followed by the cardiac myxoma’s resection. The patient’s renal function gradually improved post-surgery, and the hemodialysis was discontinued. Considering our patient and 19 other case reports of renal infarction associated with cardiac myxoma, the treatment for such a renal infarction and the outcomes differ depending on the embolus site. The poor outcome of abdominal aortic embolism requires a prompt embolectomy, whereas a branch renal artery embolism requires anticoagulation therapy to prevent thrombosis formation around the myxoma.
Multimodal Treatment of Metastatic Rectal Cancer in a Young Patient: Case Report and Literature Review
Authors: Popescu Ionuț , Dudău Ana-Maria , Dima Simona , Herlea Vlad , Croitoru Vlad M. , Dinu Ioana Mihaela , Miron Monica , Lupescu Ioana , Croitoru-Cazacu Irina M. , Dumitru Radu , Croitoru Adina Emilia
Published: April 2024

Metastatic colorectal cancer requires a multidisciplinary and individualized approach. Herein, we reported the case of a young woman diagnosed with metastatic rectal cancer who received an individualized multimodal treatment strategy that resulted in a remarkable survival. There were several particular aspects of this case, such as the early onset of the disease, the successful use of conversion therapy, the application of liquid biopsy to guide treatment, and the specific nature of the bone metastasis. To offer more insights for navigating such challenges in patients with metastatic colorectal cancer, we have conducted a literature review to find more data related to the particularities of this case. The incidence of early onset colorectal cancer is on the rise. Data suggests that it differs from older-onset colorectal cancer in terms of its pathological, epidemiological, anatomical, metabolic, and biological characteristics. Conversion therapy and surgical intervention provide an opportunity for cure and improve outcomes in metastatic colorectal cancer. It is important to approach each case individually, as every patient with limited liver disease should be considered as a candidate for secondary resection. Moreover, liquid biopsy has an important role in the individualized management of metastatic colorectal cancer patients, as it offers additional information for treatment decisions.
Comparison among Different Green Extraction Methods of Polyphenolic Compounds from Exhausted Olive Oil Pomace and the Bioactivity of the Extracts
Authors: Martins Valter F. R. , Ribeiro Tânia B. , Lopes Ana I. , Pintado Manuela E. , Morais Rui M. S. C. , Morais Alcina M. M. B.
Published: April 2024

The use of by-products as a source of bioactive compounds with economic added value is one of the objectives of a circular economy. The olive oil industry is a source of olive pomace as a by-product. The olive pomace used in the present study was the exhausted olive pomace, which is the by-product generated from the air drying and subsequent hexane extraction of residual oil from the olive pomace. The objective was to extract bioactive compounds remaining in this by-product. Various types of green extraction were used in the present study: solvent extraction (water and hydroalcoholic); ultrasound-assisted extraction; Ultra-Turrax-assisted extraction; and enzyme-assisted extraction (cellulase; viscoenzyme). The phenolic profile of each extract was determined using HPLC-DAD and the total phenolic content (TPC) and antioxidant activity (ABTS, DPPH, and ORAC) were determined as well. The results showed significant differences in the yield of extraction among the different methods used, with the enzyme-assisted, with or without ultrasound, extraction presenting the highest values. The ultrasound-assisted hydroethanolic extraction (USAHE) was the method that resulted in the highest content of the identified phenolic compounds: 2.021 ± 0.29 mg hydroxytyrosol/100 mg extract, 0.987 ± 0.09 mg tyrosol/100 mg extract, and 0.121 ± 0.005 mg catechol/100 mg extract. The conventional extraction with water at 50 °C produced the best results for TPC and antioxidant activity of the extracts. The extracts from the USAHE were able to inhibit Gram-positive bacteria, especially Bacillus cereus, showing 67.2% inhibition at 3% extract concentration.
Fractionation of Carlina acaulis L. Root Methanolic Extract as a Promising Path towards New Formulations against Bacillus cereus and Methicillin-Resistant Staphylococcus aureus
Authors: Wnorowska Sylwia , Grzegorczyk Agnieszka , Kurzepa Jacek , Maggi Filippo , Strzemski Maciej
Published: April 2024

The root of Carlina acaulis L. has been widely used in traditional medicine for its antimicrobial properties. In this study, the fractionation of methanol extract from the root was conducted. Four fractions (A, B, C, and D) were obtained and tested against a range of bacteria and fungi. The results showed promising antibacterial activity, especially against Bacillus cereus, where the minimal inhibitory concentration (MIC) was determined to be equal to 0.08 mg/mL and 0.16 mg/mL for heptane (fraction B) and ethyl acetate (fraction C), respectively. In the case of the methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300 strain, the same fractions yielded higher MIC values (2.5 and 5.0 mg/mL, respectively). This was accompanied by a lack of apparent cytotoxicity to normal human BJ foreskin fibroblasts, enterocytes derived from CaCo2 cells, and zebrafish embryos. Further analyses revealed the presence of bioactive chlorogenic acids in the fractionated extract, especially in the ethyl acetate fraction (C). These findings support the traditional use of the root from C. acaulis and pave the way for the development of new formulations for treating bacterial infections. This was further evaluated in a proof-of-concept experiment where fraction C was used in the ointment formulation, which maintained high antimicrobial activity against MRSA and displayed low toxicity towards cultured fibroblasts.
Protective Effect of Perilla Seed Meal and Perilla Seed Extract against Dextran Sulfate Sodium-Induced Ulcerative Colitis through Suppressing Inflammatory Cytokines in Mice
Authors: Sumneang Natticha , Pintha Komsak , Kongkarnka Sarawut , Suttajit Maitree , Kangwan Napapan
Published: April 2024

An excessive inflammatory response of the gastrointestinal tract is recognized as one of the major contributors to ulcerative colitis (UC). Despite this, effective preventive approaches for UC remain limited. Rosmarinic acid (RA), an enriched fraction from Perilla frutescens, has been shown to exert beneficial effects on disease-related inflammatory disorders. However, RA-enriched perilla seed meal (RAPSM) and perilla seed (RAPS) extracts have not been investigated in dextran sulfate sodium (DSS)-induced UC in mice. RAPSM and RAPS were extracted using the solvent-partitioning method and analyzed with high-pressure liquid chromatography (HPLC). Mice with UC induced using 2.5% DSS for 7 days were pretreated with RAPSM and RAPS (50, 250, 500 mg/kg). Then, the clinical manifestation, colonic histopathology, and serum proinflammatory cytokines were determined. Indeed, DSS-induced UC mice exhibited colonic pathological defects including an impaired colon structure, colon length shortening, and increased serum proinflammatory cytokines. However, RAPSM and RAPS had a protective effect at all doses by attenuating colonic pathology in DSS-induced UC mice, potentially through the suppression of proinflammatory cytokines. Concentrations of 50 mg/kg of RAPSM and RAPS were sufficient to achieve a beneficial effect in UC mice. This suggests that RAPSM and RAPS have a preventive effect against DSS-induced UC, potentially through alleviating inflammatory responses and relieving severe inflammation in the colon.
Simplifying Data Analysis in Biomedical Research: An Automated, User-Friendly Tool
Authors: Araújo Rúben , Ramalhete Luís , Viegas Ana , Von Rekowski Cristiana P. , Fonseca Tiago A. H. , Calado Cecília R. C. , Bento Luís
Published: April 2024

Robust data normalization and analysis are pivotal in biomedical research to ensure that observed differences in populations are directly attributable to the target variable, rather than disparities between control and study groups. ArsHive addresses this challenge using advanced algorithms to normalize populations (e.g., control and study groups) and perform statistical evaluations between demographic, clinical, and other variables within biomedical datasets, resulting in more balanced and unbiased analyses. The tool’s functionality extends to comprehensive data reporting, which elucidates the effects of data processing, while maintaining dataset integrity. Additionally, ArsHive is complemented by A.D.A. (Autonomous Digital Assistant), which employs OpenAI’s GPT-4 model to assist researchers with inquiries, enhancing the decision-making process. In this proof-of-concept study, we tested ArsHive on three different datasets derived from proprietary data, demonstrating its effectiveness in managing complex clinical and therapeutic information and highlighting its versatility for diverse research fields.
The Role of Black Christian Beliefs in the Civil Rights Movement: A Paradigm for a Better Understanding of Religious Freedom
Authors: Roberts Darryl Dejuan
Published: April 2024

This paper builds upon and extends Christian and legal scholarship on the civil rights movement by illuminating a climate of religious freedom that served as a catalyst for and was integral to the success of the spirited activism of the civil rights movement. To date, scholars have not extensively considered how the expansion of religious freedom in church and state jurisprudence both directly and indirectly created a climate that contributed to the success of the CRM, and how advancements in civil rights impacted the broader revolution occurring in constitutional rights. The climate of religious freedom included court support for evangelizing in residentially exclusive areas, exemptions for conscientious opposers from participating in oath swearing and other ceremonies, and exemptions from other general laws that unduly inhibited the free exercise of religious rights.