bluuebunny/crossref_metadata_2025 huggingface dataset:
Utilization of baby-friendly services in maternity wards in Serbia
Authors: Živković-Šulović Mirjana
Published: April 2024

Introduction/aim: Breastfeeding, as a topic for health promotion and research, continues to be relevant due to numerous benefits for both the child (decreased mortality, strengthening of immunity, reduction of allergies, respiratory and digestive disorders, obesity and diabetes, increased IQ) and the mother (reduced risk of hypertension, diabetes, hyperlipidemia, cardiovascular diseases, breast and ovarian cancer). The study aims to propose effective and efficient health promotion activities directed towards increasing the percentage of exclusively breastfed newborns and infants up to six months of age, in Serbia. Method: The study was conducted as a secondary analysis of data obtained in Multiple Indicator Cluster Survey 6 (MICS 6) for the national and the Roma ethnic group sample, in Serbia, in 2019. The association between the utilization of the following services: skin-to-skin contact, early breastfeeding, and full-time rooming-in for mother and baby, and the socio-demographic variables of mothers, were examined using univariate and multivariate logistic regression analysis. Statistical significance was determined at p < 0.05 (Student t-test, Pearson's chisquare test, and Mann-Whitney U-test). Results: The examined socio-economic characteristics of the mothers in both samples were not associated with the use of baby-friendly services. A significant statistical difference exists in relation to the type of delivery in both samples. Women who gave birth by caesarean section remain deprived of utilizing the procedures that have proven positive short-term and long-term effects on the health of both the child and mother. In both samples, there was a significant increase in rooming-in in the Belgrade region, where the maternity hospital leading the National Breastfeeding Support Program is located. Conclusion: The most effective measures to improve breastfeeding are related to the adoption of breastfeeding support policies in health facilities and the obligation to train the entire staff who are in contact with mothers during their stay at the maternity hospital (20-hour WHO breastfeeding counseling training).
Legal dilemmas regarding the methods of concluding distance insurance contracts: Via a mobile application and a website
Authors: Grujić Nenad
Published: April 2024

In this paper, the author states that there are two dilemmas in practice regarding the conclusion of distance insurance contracts via mobile applications and websites as a remote communication means. The first dilemma refers to the use of a double authentication as a method of concluding distance insurance contracts, while the second one concerns the permissibility of using the insurance premium payment as a method of concluding distance contracts. The author deals with both dilemmas with a functional and systemic interpretation of the provisions of the Law on the Protection of Financial Service Users in Distance Contracts and the Law of Contracts and Torts. The author concludes that a deviation from the written form of a contract is permitted, in the sense that a policyholder's double authentication is sufficient for the conclusion of a contract, and that a qualified electronic signature of the other contracting party is not required when the contract is concluded via a mobile application and a website of an insurer or a distributor. In addition, the author concludes that the insurance premium payment is an adequate method of concluding a distance contract. Finally, the author tries to provide criteria for establishing the relation between concluding a distance contract via a double authentication and the premium payment, noting that these two methods are not mutually exclusive, but complement each other.
Linguistic and stylistic means for expressing ethnocultural heterostereotypes in Serbian electronic media
Authors: Spasić Jelena
Published: April 2024

The paper presents the analysis of the most frequent linguistic and stylistic means for expressing ethnocultural heterostereotypes in Serbian electronic media. The analysis has been conducted on concrete linguistic excerpts from Serbian electronic media. The paper aims to show characteristics of linguistic and stylistic means for expressing ethnocultural heterostereotypes. The research is a contribution to journalism stylistics. The most frequent linguistic means of ethnocultural heterostereotypes in Serbian electronic media are phraseology with ethnics and metaphors. The analysis of newspaper texts in Serbian digital media showed common choices of phraseology as expressive linguistic means, used to attract and sustain attention. The use of phraseology with ethnics makes factual newspaper text more expressible and draws attention, which also has an impact on shaping ethnocultural stereotypes among readers. In reports and columns, which belong to the publicistic genre, journalists use linguistic and stylistic means for expressing ethnocultural heterotereotypes not to reinforce stereotypes, but to encourage readers to rethink established ideas about other ethnocultural communities.
Problematic mobile phone use and mental health problems in adolescents with mild intellectual disability
Authors: Arsić Bojana , Gajić Anja
Published: April 2024

In the last few decades, more people have been using mobile phones, even people with intellectual disabilities (ID). The most common consequence of excessive use of mobile phones is the emergence of mental health (MH) problems. This research aims to determine the predictors and correlation between problematic mobile phone use and MH problems in adolescents with mild ID. The sample comprised 54 adolescents of both genders who have mild ID and who attend the Vocational High School in Belgrade. The Problematic Cellular Phone Use Questionnaire was used to measure the characteristics of the respondents' use of mobile phones and the Depression, Anxiety and Stress Scale was used to measure MH problems. It was found that adolescents with mild ID have a statistically significantly high degree of problematic mobile phone use. Younger adolescents, those who use a mobile phone more time during the day and adolescents who use psychoactive substances have a higher degree of problematic mobile phone use. Girls have more MH problems compared to male adolescents. In addition, adolescents with mild ID who have a higher degree of problematic mobile phone use have more MH problems, and the presence of MH problems in one domain is positively correlated with the presence of others. In conclusion, we highlight the limitations as well as recommendations for future researchers and practitioners working with this population.
Wars, traumas, and identities in the Serbian novel 1991-2021 (II)
Authors: Brajović Tihomir
Published: April 2024

The second part of the paper deals with the testimonial-representative paradigm as a choice based on the personal expression of unique experiences of traumatic events as a frame for contemporary concrete understanding and a kind of cathartic solution to identity contradictions. The outcome shows that both paradigms could also be productive in articulating adequate identity politics and/or principle understandings of identity problems only if they consider each other as balancing possibilities.
On the origins of the context and meaning of the motif of dolphin on the ship-shaped oil lamp from the museum of Smederevo (4th century AD)
Authors: Gavrilović Anđela
Published: April 2024

The dolphin motif on the ship-shaped oil lamp treasured in the Museum of Smederevo (4th century AD) has complex iconography, multi-layered and complex symbolism, and a long history. This article presents and explains how its iconography and meaning were gradually formed and developed in ancient Greek and Roman art, as well as the peculiarities of its gradual transformation into a Christian symbol. It is found that the context of the appearance of the dolphin motif in art during different epochs is not a mere coincidence, but the expression of a clear intention on the part of particularly learned artists and commissioners of works of art. Since there are no written records of this motif that would explain its iconography and meaning, and since the motif itself is by nature very hermetic, and at the same time very rare, the characteristic context of the appearance of the dolphin motif in art is also a decisive parameter for analyzing its meaning and its gradual formation.
Frequency of anglicisms in verbal associations of English language students
Authors: Kulić Danijela
Published: April 2024

The paper deals with the research on the prevalence of recent anglicisms in the everyday language of the students at the Department of English Language and Literature of the Faculty of Philosophy in Kosovska Mitrovica. Since the anglicisms that have entered the Serbian language in the last two decades are the result of progress in information and computer technology, the goal of this research is to assess the most common Englishorigin vocabulary, especially in the speech of older adolescents. Although the sample was a group of English language students (N=50), it is assumed that their everyday language reflects the language of the wider population of students of English language and literature, which should be examined by including a much larger number of English speakers from different universities in Serbia, in order to reach more reliable results. One of the tasks of the linguists is to preserve the Serbian language from the influx of foreign words, while the role of lexicographers is to publish new dictionaries including all foreign words that enter the Serbian language and persist there. New words of English origin multiply every day in contact with content found on the Internet, starting from social networks, blogs that offer advice for various problems, sites that are full of lexical units originating from the English language, films, series, and so-called "tutorials" that are especially followed by the younger population. This paper will not discuss the justification of the use of anglicisms found, but an attempt will be made to find those that are most frequent, and thus the lexicon that, whether we like it or not, entered the Serbian language. The study relies on the free verbal association method to identify frequent lexical units originating from English. Comparative analysis is performed using the latest dictionaries Rečnik novih reči u srpskom jeziku 1 (Otašević i dr. 2022), abbreviated as RNR, and Srpski rečnik novijih anglicizama (Prćić et al. 2021), abbreviated as SRNA. Consequently, the paper highlights the most frequent lexical units from the students' perspective that are not listed in the dictionaries RNR (2022) and SRNA (2021). Through free verbal associations, students wrote anglicisms they use in their speech. The diversity in the choice of alphabets, as well as forms that the students chose while writing anglicisms, would be determined. This research, although it has shortcomings in terms of the small number of respondents, can still provide valid data in the field of lexicography and contact linguistics.
Development of marketing management for pomelo products in Samut Songkhram province, Thailand
Authors: Vorasiha Ekgnarong , Soonthornpipit Hathaipan , Chuvichian Pannawat , Lertasawaphat Phachok , Sornsawan Kassamara , Khan Majid
Published: April 2024

The study presents a comprehensive examination of the market potential for Pomelo products in Samut Songkhram Province, Thailand, aiming to enhance marketing management strategies. It delves into consumer motivations, attitudes, and purchasing intentions towards Pomelo products, utilizing structural equation modeling to assess influencing factors. Samut Songkhram is identified as a prime region for Pomelo cultivation due to its unique river estuary soil enriched with minerals, creating a distinct taste profile influenced by a mix of saltwater, brackish water, and freshwater, dubbed the three-water area. This geographical and environmental advantage contributes to the high quality and consumer preference for the large white Pomelo variety indigenous to the area. The study explores two primary agricultural practices for growing large white Pomelos: self-cultivation by landowners and orchard leasing by other farmers. Additionally, it investigates two main distribution methods: direct sales at the farm and self-managed sales by farmers or orchard owners. A quantitative analysis involving 400 potential customers, including tourists and out-of-area customers, was conducted to gauge purchase intentions. Results from structural equation modeling indicate a significant and positive relationship between consumer motivations, attitudes, and purchase intentions, underlining the integrated influence of these factors on consumer behavior towards Pomelo products. These findings highlight the critical role of understanding consumer dynamics and the environmental uniqueness of Samut Songkhram’s Pomelos in developing targeted marketing strategies. The research underscores the significance of leveraging the unique characteristics and cultivation heritage of Samut Songkhram Pomelos to foster product differentiation and appeal, suggesting a need for innovative marketing approaches that resonate with the distinct quality and taste profiles of these local fruits.
El ‘espíritu de Allah’: el Ayatolá Jomeini y los fundamentos políticos de la República Islámica
Authors: Moya Mena Sergio I.
Published: April 2024

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Reseña de: Vega RODRÍGUEZ-FLORES, Vertebrar España. El PSOE: de la autodeterminación a la LOAPA (1974-1982), Madrid, CSIC, 2021
Authors: León Cáceres Guillermo
Published: April 2024

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El disputado voto del señor Casero
Authors: Dueñas Castrillo Andrés
Published: April 2024

Este artículo resuelve algunas de las controversias jurídicas planteadas a partir del error en la emisión del voto telemático del diputado Casero Ávila en la sesión plenaria del Congreso de los Diputados del 3 de febrero de 2022, que permitió la convalidación del Real Decreto-ley 32/2022. En este trabajo se aclara cuál es la norma parámetro de enjuiciabilidad del caso, si existió o no vulneración del ius in officium del diputado o si se produjo o no un vicio en el procedimiento legislativo. Antes de resolver tales interrogantes, se realiza un análisis de la regulación del voto telemático en los Parlamentos españoles y el contexto de pandemia en el que se produjo el supuesto a analizar.
Karlsruhes Vollstrecker
Authors: Kirchner Raven
Published: April 2024

Binnen weniger Wochen – und nach kurzzeitigem Ausstieg der CDU/CSU-Fraktion aus der Debatte – hat das Bundesjustizministerium einen Referentenvorschlag zur Änderung des Grundgesetzes zur Verankerung zusätzlicher Schutzmechanismen im Grundgesetz vorgelegt, über den nunmehr beraten wird. Ein Blick in die Historie des Bundesverfassungsgerichts und die Erfahrungen verschiedener ausländischer Verfassungsgerichte mit der Politik offenbaren jedoch, dass es nicht erst autoritärer politischer Parteien oder Strömungen bedarf, um die verfassungsgerichtliche Kontrolle auszuhebeln. Der Blick ist daher auf die Mittel zu richten, die sicherstellen können, dass die Entscheidungen Karlsruhes von allen Staatsorganen befolgt werden.
Potential importing commodities to the Czech Republic from Vietnam: Vietnam Market Research
Authors: Huynh Quynh Thi Ngoc , Vrba Jan
Published: April 2024

The primary objective of this research paper is to provide a comprehensive overview of the results and findings obtained through a quantitative research study focused on exploring import-export possibilities between the Czech Republic and Vietnam. By conducting this research, we aim to shed light on the current state of trade between these two countries and identify potential opportunities for further collaboration. Throughout the study, various quantitative research methods were employed to collect and analyze relevant data pertaining to the import and export activities between the Czech Republic and Vietnam. These methods included data collection from official trade statistics, surveys conducted with industry experts and stakeholders, and econometric modeling to assess the economic viability of different trade scenarios.
Streamlining Compliance: Orchestrating Automated Checks for Cloud-based AI/ML Workflows
Authors: Bayani Samir Vinayak , Tillu Ravish , Jeyaraman Jawaharbabu
Published: April 2024

Ensuring security and safeguarding data privacy within cloud workflows has garnered considerable attention in research circles. For instance, protecting the confidentiality of patients' private data managed within a cloud-deployed workflow is crucial, as is ensuring secure communication of such sensitive information among various stakeholders. In light of this, our paper proposes an architecture and a formal model for enforcing security within cloud workflow orchestration. The proposed architecture underscores the importance of monitoring cloud resources, workflow tasks, and data to identify and anticipate anomalies in cloud workflow orchestration. To achieve this, we advocate a multi-modal approach combining deep learning, one-class classification, and clustering techniques. In summary, our proposed architecture offers a comprehensive solution to security enforcement within cloud workflow orchestration, leveraging advanced techniques like deep learning for anomaly detection and prediction, particularly pertinent in critical domains such as healthcare during unprecedented times like the COVID-19 pandemic.
Unifying Assurance A Framework for Ensuring Cloud Compliance in AIML Deployment
Authors: Bayani Samir Vinayak , Prakash Sanjeev , Arasu Malaiyappan Jesu Narkarunai
Published: April 2024

Intrusion poses a significant challenge in Cloud networks, necessitating the development of efficient mechanisms to mitigate intrusions and enhance system security. To address this, we propose a novel Artificial Bee-based Elman Neural Security Framework (ABENSF). This framework involves rescaling the raw dataset using preprocessing functions and integrating an optimal fitness function based on artificial bees into the feature extraction phase to identify and extract attack features. Additionally, the monitoring mechanism in ABENSF enhances network security by proactively preventing attacks. By employing tracking and monitoring functions, known and unknown attacks can be effectively thwarted. We validate the proposed framework using the NSL-KDD dataset in Python software and conduct a comparative analysis to assess its performance against existing techniques. Our results demonstrate that the developed model outperforms other methods in terms of attack prevention and overall security enhancement.
Vaikuttavuustutkimus: Satunnaistettu vertailukoe tulee suunnitella huolella
Authors: Hinkka-Yli-Salomäki Sanna
Published: April 2024

Vaikuttavuustutkimuksessa pyritään osoittamaan mahdollisimman yksiselitteisesti,että saatu ­vaikutus on kokeessa riippumattomaksi muuttujaksi määritellyn tekijän tuottama.

Satunnaistettua vertailukoetta pidetään luotettavimpana tapana mitata intervention ­vaikuttavuutta.

Satunnaistamisella pyritään siihen, että ryhmät ovat mahdollisimman samankaltaisiamuiden kuin tutkittavien vaikuttavien tekijöiden osalta.

Koetta suunniteltaessa tulee määritellä kohdejoukko, verrokkiryhmät, päämuuttuja jamahdolliset toissijaiset vasteet sekä nollahypoteesi. Myös otoskoko tulee laskea.

Suunnittelussa tarvitaan tietoa tutkimuslainsäädännöstä, lupaprosessista, eettisistä asioista, ­statistiikasta ja tutkimusdatan keräämisestä.
Instructors’ Conceptions of the Efficacy and Motives for Online Instruction in Open and Distance Learning Mode
Authors: Sanga Philipo
Published: April 2024

This paper employs the Community of Inquiry Theoretical Framework to examine the instructors’ conceptions of training efficacy and motives for online instruction in open and distance learning mode at the Open University of Tanzania (OUT). Using a hermeneutic phenomenology research design, data were collected from 25 instructors at the Open University of Tanzania through in-depth interviews, which were corroborated with questionnaires. Findings from the study indicated that, generally, continuous professional development significantly impacts how instructors teach in the online environment. Although most participants rated training as an effective strategy for online instruction, the programmes lacked regularity and fell short of more relevant training programmes. More specifically, findings indicated that the training package missed some essential contents required by instructors. A wide range of motives for conducting online training is elaborated. This paper recommends that institutions invest in relevant regular training programs for online instructors and ensure comprehensive training packages. Keywords: distance learning, online instruction, online learning, open and distance learning, open learning
Effect of Heating Rate on Melting Point of HMX, RDX, TNT and PETN
Authors: Das Roshnee , Trivedi Nikhilesh S.
Published: April 2024

Melting point of HMX, RDX, TNT and PETN are measured for judging crystal purity. The heating rate when doing this has a significant effect on the melting point reading. This work gives an insight on how heating rate affects the melting point reading for these high explosives using Differential Scanning Calorimetry (DSC). With increase in heating rates (from 1 to 20°C min-1) the different behaviours of the DSC curves for HMX, RDX, TNT and PETN are analysed. It is also observed from this study that heating rate causes a shift in the temperatures for onset and the peak for HMX, RDX, TNT and PETN. This study reflects that in some cases the decomposition of the explosives is influencing the melting graphs. Hence a conclusion has been drawn on the adequate heating rate that should be chosen for determining the melting point of these high explosives.
La Gestión del Talento Humano en la Esfera Académica
Authors: Vargas Prado Kelly Fara , Jurado Enriquez Elizabeth Lizbel , Talla Linderman Magdalena Cecilia , Huamán Narvay José , Campos Sobrino Medalith del Rocio , Campos Martinez Silvana Rosario
Published: April 2024

La finalidad de este estudio es determinar la influencia de la gestión del talento humano como elemento de valor en la productividad académica de docentes universitarios en el Perú. De tipo básica, corte transversal, nivel explicativo; la muestra fueron 110 docentes universitarios elegidos a través de un muestreo no probabilístico por conveniencia, quienes dieron respuesta a dos cuestionarios que evaluaban la gestión del talento humano y la productividad académica. Los resultados evidenciaron que la gestión del talento humano como elemento de valor influye significativamente en un 57,0% en la productividad académica.
Comunicación, Marketing Digital y Salud
Authors: Jiménez Marín Gloria , Fernandez-Osso Fuentes Maria
Published: April 2024

El creciente uso de formatos digitales en el sistema publicitario español ha contribuido a un cambio importante en el marketing, por lo que los influencers son cada vez más demandados por las marcas.
El objetivo del artículo es evidenciar la prescripción que suponen estos perfiles y descubrir si afectan al trabajo de las agencias (plan de marketing, planificación estratégica o de medios, creatividad…) siendo un elemento estructural. La metodología combina métodos cualitativos y cuantitativos: entrevistas en profundidad, encuesta y Delphi.
Los resultados muestran el importante papel de estos perfiles sociales para sociedad, usuarios finales y empresas de comunicación y marketing.
La presencia docente con medios audiovisuales en escenarios virtuales en la educación superior en Arequipa
Authors: Vera-Ninacondor Carlos Pedro , Ortiz-Valderrama Cecilia del  Carmen , Aguilar-Gonzales Jose Luis , Gamarra-Castellanos María Elena
Published: April 2024

Los procesos de innovación de las tecnologías de la información en la didáctica de la educación superior no han sido procesos sincronizados, las transformaciones tecnológicas no van en paralelo con las adaptaciones pedagógicas, sin embargo, la irrupción violenta de la pandemia del COVI19 hizo evidente esa distancia; el objetivo de la investigación es identificar el valor de la presencia docente con medios audiovisuales en el auditorio virtual identificando las relaciones de motivación y confianza de los estudiantes con el objeto de replantear un escenario virtual optimo. El estudio analiza los niveles de confianza y las motivaciones que genera la percepción visual del docente, la participación de 127 estudiantes de ciencias de la comunicación; la perspectiva temporal es transeccional descriptiva, con un enfoque cuantitativo.
Essential Oils from the Perspective of Dentistry
Authors: Carvalho Driany Tamami Yamashita de , Souza Heide Mendonça Moreira de , Assis Priscila Helena de , Alciati Carla Alves de Siqueira , Ortolani Cristina Lúcia Feijó
Published: April 2024

Introduction: With a significant increase in interest in recent years regarding essential oils, the purpose of this work was to identify how Dentistry has researched and utilized these substances through an integrative review of articles available in indexed databases. The bibliographic survey was conducted in November and December 2022, through electronic research, consulting the Pubmed and LILACS databases. The descriptors and boolean operators used were: "volatile oils" OR "essential oils" AND "dentistry". The material published between 2018 and 2022 indexed in the mentioned databases and with a free version was included. Studies that did not address the proposed study theme were excluded. Material and Method: Out of 104 scientific articles found, 29 studies were reviewed and analyzed. Result and Discussion: A variety of plant derivatives have been studied for their inhibitory effect on C. albicans biofilms and for cytotoxicity, several are considered promising for the development of future research and bioproducts applicable to human health. Clinical studies indicated that the EOs from Pelargonium graveolens and Zataria multiflora are potentially effective in treating oral candidiasis, and the most promising EOs were obtained from Allium tubeorosum, Cinnamomum cassia, Cinnamomum zeylanicum, and Coriandrum sativum L. Further non-clinical and clinical studies with these EOs are necessary to determine their potential use and safety for the treatment of oral candidiasis. Listerine mouthwash was often compared with other chemical agents, mainly chlorhexidine, which in terms of plaque control is considered the gold standard in efficacy and substantivity. However, the use of chlorhexidine has disadvantages like altered taste sensations, teeth discoloration. With all this, the World Health Organization (WHO) recommended that researchers analyze the use of natural products, such as extracts of herbs and plants, to combat these negative effects. In another randomized study, they concluded that the mouthwash containing aqueous extracts of essential oils was as effective antibacterial agents as chlorhexidine mouthwashes, corroborating with other descriptive and experimental studies. Conclusion: The articles demonstrated extensive study regarding essential oils in Dentistry, presenting various applications that are still being explored: they have potential in the development of preventive or therapeutic agents for various oral diseases, use in dental materials, and popular applications. There is still a need for more clinical trials to establish safety and efficacy in oral health due to the wide variety of existing essential oils.
Peningkatan Kompetensi Digital Guru SMK Melalui in House Training
Authors: Arifuddin Arifuddin , Machmud Mulyana
Published: April 2024

Tujuan kegiatan Pengabdian kepada masyarakat ini agar guru SMK Negeri 2 Kota Parepare memiliki pemahaman dan kompetensi terkait implementasi kurikulum merdeka. Salah satu materinya adalah Peningkatan Kompetensi Digital Melalui in House Training. Metode yang digunakan yaitu dengan koordinasi dan sinkronisasi dengan mitra yaitu para guru Negeri 2 Parepare, pelatihan dan pendampingan sistem Sistem Digital Kearsipan Elektronik. Hasil yang diperoleh adalah 1) Peningkatan informasi dan wawasan di kalangan guru SMK, 2) Guru SMK juga jadi memiliki ketrampilan dalam penggunaan software sistem kerasipan berbasis digital, 3) Lebih dari 80% para guru SMK memiliki kemampuan tentang sistem pengarsipan berbasis digital yang sangat baik.
Sosialisasi UMKM di Desa Wisata Lewaja Kabupaten Enrekang
Authors: Ulum Bahrul , Soraya Anugra , Hasrianti Hasrianti , Ali Syahban Mada , Syahril Muh. Akbar Fhad
Published: April 2024

Program Pengabdian Kepada Masyarakat dengan judul "Sosialisasi UMKM Desa Wisata Lewaja Kabupaten Enrekang" bertujuan untuk meningkatkan kapasitas dan daya saing Usaha Mikro, Kecil, dan Menengah (UMKM) di Desa Wisata Lewaja. Melalui pendekatan pelatihan dan workshop interaktif, para pengelola UMKM diberikan pengetahuan mendalam mengenai manajemen UMKM, strategi pengembangan pariwisata, dan penerapan teknologi informasi. Selain itu, program ini juga memfasilitasi terbentuknya jaringan kolaboratif antar pengelola UMKM untuk saling berbagi pengalaman dan mendukung pertumbuhan bisnis mereka. Hasil dari program ini mencakup peningkatan pengetahuan dan keterampilan para peserta dalam mengelola UMKM pariwisata, membentuk jaringan kolaboratif yang kuat, dan meningkatkan kualitas produk dan layanan yang ditawarkan oleh UMKM. Dengan adanya peningkatan kapasitas dan daya saing, diharapkan UMKM di Desa Wisata Lewaja mampu bersaing secara efektif di pasar pariwisata. Selain memberikan manfaat ekonomi bagi pengelola UMKM, program ini juga berdampak positif pada pemberdayaan tenaga kerja lokal dan kontribusi terhadap pembangunan ekonomi di Kabupaten Enrekang. Dengan demikian, program ini merupakan langkah strategis dalam memaksimalkan potensi pariwisata dan ekonomi lokal Desa Wisata Lewaja.
Pendampingan Advertisement dan Labelling Pada Usaha Mikro Kecil Menengah (UMKM) Masyarakat Parepare “Naskun Tante Yanti”
Authors: Mada Ali Syahban , Rustam Utary , Jahara Jahara
Published: April 2024

Tujuan dari pengabdian ini yaitu untuk mengetahui apa saja cara yang dapat dilakukan agar bisa mengembangkan dan meningkatkan usaha dagang melalui periklanan dan labelling. Metode yang digunakan dalam pengabdian ini adalah partisifatif, dimana pelaksana mendampingi secara langsung pelaku UMKM di kota Parepare dalam mengembangkan usaha dagangnya yaitu melalui periklanan dan pemberian label pada usahanya.
Pengelolaan Pemasaran Melalui Media Sosial: Membangun Citra Positif Mahasiswa IAS Melalui Pendampingan Promosi
Authors: Amir Hasbiyah , Rustam Utary , Sudarmono Sudarmono
Published: April 2024

Pendampingan Promosi menggunakan media sosial pada Organisasi Mahasiswa Kewirausahaan IAS bertujuan untuk mengetahui peluang penjualan melalui promosi melalui media sosial. Metode yang digunakan adalah wacana, sesi tanya jawab dan praktek. Pendamping adalah seseorang atau kelompok yang memberikan nasehat dan bimbingan kepada perusahaan atau pengusaha untuk meningkatkan kinerjanya. Melakukan promosi dengan menggunakan media sosial sepertinya mempunyai peluang yang baik jika dilakukan dengan cara yang menarik. Facebook merupakan salah satu media sosial yang sering digunakan namun tidak menutup kemungkinan juga ada media sosial lain yang digunakan untuk berpromosi seperti Instagram dan WhatsApp
Dorong Etika Demokrasi: Mengekang Gejala Politik Uang Dalam Proses Pemilihan
Authors: Suryani Lilis , Tahir Muhammad
Published: April 2024

Money Politic sebagai bentuk kejahatan pemilu yg menjadi kebiasaan buruk mewarnai demokrasi Indonesia,  esensi demokrasi dalam pilkada  adalah hubungan kontraktual antara kandidat calon bupati dan wakil bupati dengan partai politik dan konstituen, politik uang uang menjadi satu benteng yg harus dirobohkan karena akan menciderai tananan sistem hukum dalam pilkada Indosia, permasalahannya adalah bagaimana solusi dalam mencegah terjadinya transaksi politik uang dalam pilkada proses analisis yang menjadi alternatif adalah menggunakan metode kualitatif dengan data empirik histori, melalui sosialisasi, dan tatap muka, pengamatan partisipan dan jumlah partisipasi dari konteks politik uang, peran lembaga dalam proses  edukasi penyadaran massa lewat pintu partai dan tokoh masyarakat menjadi satu alternatif solusi untuk menutup jalur pelanggaran hukum pemilu, di sisi lain kesadaran masyarakt dan partai politik serta calonlah  yang sangat memegang Peran dalam memutus mata rantai penyebaran transaksi money politic.
Pendidikan Politik Hukum Bagi Mahasiswa Menjelang Pemilihan Presiden Tahun 2024
Authors: Wiwin Wiwin , Alam M. Rachmat Sjamsu
Published: April 2024

Kegiatan pendidikan politik hukum bagi mahasiswa menjelang Pemilihan Presiden 2024 bertujuan memberikan pemahaman mendalam tentang putusan Mahkamah Konstitusi terkait batas usia pencalonan Presiden dan Wakil Presiden. Melalui metode seminar dan sesi tanya jawab, kegiatan ini melibatkan pemateri dari berbagai latar belakang akademis dan politisi. Diskusi berfokus pada analisis putusan Mahkamah Konstitusi dengan tema "Ada Apa dengan MK: Analisis Putusan MK Tentang Batas Usia Capres dan Cawapres". Kegiatan diadakan di Aula IAIN Parepare dan dihadiri oleh mahasiswa dari berbagai kampus di Kota Parepare. Melalui interaksi yang dinamis antara pemateri dan mahasiswa, kegiatan ini berupaya meningkatkan pemahaman, memperluas wawasan, dan membangun keterlibatan aktif mahasiswa dalam memahami dan mempersiapkan diri menghadapi proses demokrasi masa depan. Kegiatan pendidikan politik hukum bagi mahasiswa dalam persiapan menyongsong Pemilihan Presiden 2024 menjadi tonggak penting dalam mempersiapkan mahasiswa sebagai agen perubahan dan pemilih yang terinformasi. Melalui kegiatan ini, mahasiswa tidak hanya diberikan pemahaman yang mendalam terkait putusan Mahkamah Konstitusi tentang batas usia pencalonan Presiden dan Wakil Presiden, tetapi juga dibekali dengan keterampilan kritis dan pemahaman yang lebih luas mengenai aspek hukum dan politik yang memengaruhi proses demokrasi. Melalui pemberian pengetahuan dan pemahaman yang lebih mendalam ini, mahasiswa dapat menjadi pemilih yang lebih bertanggung jawab dan pemimpin yang terlatih dalam mengemban tugas-tugasnya di masa mendatang.
Morphology of the Buluus, Ulakhan-Taryn aufeis, conditions of its occurrence and stable oxygen and hydrogen isotope variations in the lower part
Authors: Vasil'chuk Yurij Kirillovich , Ginzburg Alexander Pavlovich , Tokarev Igor' Vladimirovich , Budantseva Nadine Arkad'evna , Vasil'chuk Alla Constantinovna , Palamarchuk Valentina Anatol'evna , Bludushkina Lyubov' Bakhtiyarovna , Slyshkina Elena Sergeevna
Published: April 2024

Aufeis is one of the most dangerous natural phenomena. The negative impact of aufeis is determined by the unexpected flooding of the territory and subsequent freezing of water, the formation of ice barriers, the icing of underground structures and communications (mines, tunnels, culverts, and sewer wells), as well as the icing of roads and railways, coastal hydraulic structures, etc. There are cases when explosions of aufeis mounds produce catastrophic disturbances within a few seconds. The aufeis that forms annually in the valley of the Buluus Creek is one of the most famous and studied aufeis of Central Yakutia. The aufeis was sampled from a vertical section. The aufeis is layered, and the thickness of the layers is 3-10 cm. In the upper part of the aufeis, the ice layers are thicker than in the lower. Sampling from the aufeis ice was carried out using a 5.1-cm-diameter steel crown driven by a Bosch electric drill. Measurements of the isotopic composition of oxygen and hydrogen in ice were performed using a Picarro L 2130-i laser isotope analyzer. The isotopic composition of the Buluus ice varies in a narrow range: δ18O values vary from −20.2 to −21.9‰, δ2H values vary from −159.5 to −173.7‰. Generally, the ice is isotopically slightly enriched compared to the surface water of the Ulakhan-Taryn creek, where the δ18O value is −22.18‰ and the δ2H value is −175.1%. Groundwater is isotopically close to the creek water; its isotope composition is also isotopically enriched compared to the ice of the aufeis, with δ18O values varying from −22.17 to −22.25‰ and δ2H values varying from −173.7 to −175.1‰.
Between Kochel and Kalmunz. Early plein airs by Gabriele Munter at the school "Phalanx" by Vasily Kandinsky.
Authors: Matyunina Daria Stanislavovna , Semyonova Maria Aleksandrovna , Habibova Alevtina Sakmarovna
Published: April 2024

The subject of the study of the proposed article is the early plein-air works of the German expressionist artist Gabriele Munter, later a member of the Blue Horseman art association, a student and friend of Vasily Kandinsky. The authors of the article aim to review and introduce into scientific circulation a number of Munter's sketches created by her during summer trips to the plein air in 1902-1903 to the Alpine towns of Kochel and Kalmunz with the Munich art school "Phalanx", headed by Kandinsky. The article also examines the picturesque plein-air works by Kandinsky, created by him in the same years there, in Bavaria - mainly landscapes and sketches of figures in the landscape. The authors of the study see as their task to trace the influence of Kandinsky's artistic manner and his role as a teacher on the formation of a Munter painter.  The research methodology includes formal stylistic, comparative methods of art criticism analysis, as well as a comprehensive historical and biographical approach. The relevance of the study is due to its scientific novelty: the authors of the article for the first time in Russian-language art history literature describe the pre-expressionist works of Munter during the period of joint plein-airs with Kandinsky, trace the formation of her artistic vision and picturesque manner, the influence of Kandinsky on her formation. The development of the impressionistic technique common to Munter and Kandinsky in the early 1900s, according to the authors of the article, is combined with individual searches for expressiveness of form and color. The first experiments of plein-air oil painting in a special "spatula technique" under the guidance of Kandinsky were accompanied by the successful search for Munter in the field of graphics, mastering the technique of printing color woodcuts. The authors of the article come to the conclusion that the formation of the original manner of Munter was equally influenced by both pictorial emancipation through sketching practice in oil, as well as their own experiences in drawing and engraving.
DUX4 is a common driver of immune evasion and immunotherapy failure in metastatic cancers
Authors: Pineda Jose Mario Bello , Bradley Robert K.
Published: April 2024

Cancer immune evasion contributes to checkpoint immunotherapy failure in many patients with metastatic cancers. The embryonic transcription factor DUX4 was recently characterized as a suppressor of interferon-γ signaling and antigen presentation that is aberrantly expressed in a small subset of primary tumors. Here, we report that
DUX4
expression is a common feature of metastatic tumors, with ∼10-50% of advanced bladder, breast, kidney, prostate, and skin cancers expressing
DUX4
.
DUX4
expression is significantly associated with immune cell exclusion and decreased objective response to PD-L1 blockade in a large cohort of urothelial carcinoma patients.
DUX4
expression is a significant predictor of survival even after accounting for tumor mutational burden and other molecular and clinical features in this cohort, with
DUX4
expression associated with a median reduction in survival of over one year. Our data motivate future attempts to develop DUX4 as a biomarker and therapeutic target for checkpoint immunotherapy resistance.
Evolutionary trade-offs in dormancy phenology
Authors: Constant Théo , Dobson F. Stephen , Habold Caroline , Giroud Sylvain
Published: April 2024

Seasonal animal dormancy, hibernation or diapause, is widely interpreted as a physiological response for surviving energetic challenges during the harshest times of the year (the physiological constraint hypothesis). However, there are other mutually non-exclusive hypotheses to explain the timing of animal dormancy, that is, entry into and emergence from hibernation (i.e. dormancy phenology). Other survival advantages of dormancy that have been proposed are reduced risks of predation and competition (the “life-history” hypothesis), but comparative tests across animal species are not yet available. Under this hypothesis, dormancy phenology is influenced by a trade-off between reproductive advantages of being active and survival benefits of dormancy. Within a species, males and females differ in the amount of time and energy they invest in reproduction. Thus, the trade-off between reproduction and survival may be reflected by within-species sex differences in the phenology of dormancy. To examine this hypothesis, we used two complementary approaches: (i) a set of phylogenetic comparative analyses on mammals (mainly holarctic rodents), and (ii) a comparison between endotherm and ectotherm dormancy, via analyses of endotherms (including mainly holoarctic rodents) and the existing literature on ectotherms.Using the phylogenetic comparative method applied to more than 20 hibernating mammalian species, we found support for both hypotheses as explanations for the phenology of dormancy. In accordance with the life history hypotheses, sex differences in emergence and immergence were favored by the sex difference in reproductive effort. In addition, physiological constraint may influence the trade-off between survival and reproduction such that, low temperature and precipitation as well as smaller body mass influence sex differences in phenology. We also compiled initial evidence that ectotherm dormancy (invertebrates and reptiles) may be 1) less temperature dependent than previously thought and 2) associated with trade-offs consistent with the life history hypothesis. Dormancy in some endotherms and ectotherms show staggered phenology with respect to the growing season (earlier emergence and immergence than expected) which illustrates the selection pressure exerted by the trade-off between reproduction (earlier emergence than expected) and adult survival (earlier immergence than expected). Thus, dormancy during non-life-threatening periods that are unfavorable for reproduction may be more widespread than previously appreciated.
The substrate-binding domains of the osmoregulatory ABC importer OpuA transiently interact
Authors: van den Noort Marco , Drougkas Panagiotis , Paulino Cristina , Poolman Bert
Published: April 2024

Bacteria utilize various strategies to prevent internal dehydration during hypertonic stress. A common approach to countering the effects of the stress is to import compatible solutes such as glycine betaine, leading to simultaneous passive water fluxes following the osmotic gradient. OpuA from
Lactococcus lactis
is a type I ABC-importer that uses two substrate-binding domains (SBDs) to capture extracellular glycine betaine and deliver the substrate to the transmembrane domains for subsequent transport. OpuA senses osmotic stress via changes in the internal ionic strength and is furthermore regulated by the 2
nd
messenger cyclic-di-AMP. We now show, by means of solution-based single-molecule FRET and analysis with multi-parameter photon-by-photon hidden Markov modeling, that the SBDs transiently interact in an ionic strength-dependent manner. The smFRET data are in accordance with the apparent cooperativity in transport and supported by new cryo-EM data of OpuA. We propose that the physical interactions between SBDs and cooperativity in substrate delivery are part of the transport mechanism.
Neural network emulation of the human ventricular cardiomyocyte action potential for more efficient computations in pharmacological studies
Authors: Grandits Thomas , Augustin Christoph M , Haase Gundolf , Jost Norbert , Mirams Gary R , Niederer Steven A , Plank Gernot , Varró András , Virág László , Jung Alexander
Published: April 2024

Computer models of the human ventricular cardiomyocyte action potential (AP) have reached a level of detail and maturity that has led to an increasing number of applications in the pharmaceutical sector. However, interfacing the models with experimental data can become a significant computational burden. To mitigate the computational burden, the present study introduces a neural network (NN) that emulates the AP for given maximum conductances of selected ion channels, pumps, and exchangers. Its applicability in pharmacological studies was tested on synthetic and experimental data. The NN emulator potentially enables massive speed-ups compared to regular simulations and the forward problem (find drugged AP for pharmacological parameters defined as scaling factors of control maximum conductances) on synthetic data could be solved with average root-mean-square errors (RMSE) of 0.47 mV in normal APs and of 14.5 mV in abnormal APs exhibiting early afterdepolarizations (72.5% of the emulated APs were alining with the abnormality, and the substantial majority of the remaining APs demonstrated pronounced proximity). This demonstrates not only very fast and mostly very accurate AP emulations but also the capability of accounting for discontinuities, a major advantage over existing emulation strategies. Furthermore, the inverse problem (find pharmacological parameters for control and drugged APs through optimization) on synthetic data could be solved with high accuracy shown by a maximum RMSE of 0.22 in the estimated pharmacological parameters. However, notable mismatches were observed between pharmacological parameters estimated from experimental data and distributions obtained from the Comprehensive in vitro Proarrhythmia Assay initiative. This reveals larger inaccuracies which can be attributed particularly to the fact that small tissue preparations were studied while the emulator was trained on single cardiomyocyte data. Overall, our study highlights the potential of NN emulators as powerful tool for an increased efficiency in future quantitative systems pharmacology studies.
The Listeria monocytogenes persistence factor ClpL is a potent stand-alone disaggregase
Authors: Bohl Valentin , Hollmann Nele Merret , Melzer Tobias , Katikaridis Panagiotis , Meins Lena , Simon Bernd , Flemming Dirk , Sinning Irmgard , Hennig Janosch , Mogk Axel
Published: April 2024

Heat stress can cause cell death by triggering the aggregation of essential proteins. In bacteria, aggregated proteins are rescued by the canonical Hsp70/AAA+ (ClpB) bi-chaperone disaggregase. Man-made, severe stress conditions applied during, e.g., food processing represent a novel threat for bacteria by exceeding the capacity of the Hsp70/ClpB system. Here, we report on the potent autonomous AAA+ disaggregase ClpL from Listeria monocytogenes that provides enhanced heat resistance to the food-borne pathogen enabling persistence in adverse environments. ClpL shows increased thermal stability and enhanced disaggregation power compared to Hsp70/ClpB, enabling it to withstand severe heat stress and to solubilize tight aggregates. ClpL binds to protein aggregates via aromatic residues present in its N-terminal domain (NTD) that adopts a partially folded and dynamic conformation. Target specificity is achieved by simultaneous interactions of multiple NTDs with the aggregate surface. ClpL shows remarkable structural plasticity by forming diverse higher assembly states through interacting ClpL rings. NTDs become largely sequestered upon ClpL ring interactions. Stabilizing ring assemblies by engineered disulfide bonds strongly reduces disaggregation activity, suggesting that they represent storage states.