bluuebunny/crossref_metadata_2025 huggingface dataset:
Profile of several autoantibodies, complement and vitamin D levels in Brazilian patients with Chikungunya infection
Authors: Carvalho J. F. , Cordeiro L. R. , Silva F. F. , Mota L. , Rodrigues C. , Andrade C. F. , Caldas C.
Published: November 2021

Introduction. Chikungunya virus infection (CKV) may lead to chronic arthritis in up to 40% of the patients. There are previous data regarding positive auto antibodies in CKV. Objective is to systematically evaluate the prevalence of auto antibodies in CKV patients. Methods. All study participants had clinical manifestations being CKV positive at least serologally or by RT-PCR data. The following autoantibodies were assessed: antinuclear antibodies (ANA), anti-dsDNA, anti-Sm, anti-Ro/SS-A, anti-La/SS-B, anti-U1RNP, IgG and IgM anticardiolipin, anticyclic citrullinated peptide (antiCCP), rheumatoid factor (RF), antiribosomal P protein, lupus anticoagulant, anti-Jo-1 and anti-Scl-70. CH100, C3 and C4 complement components, serum levels of immunoglobulins, C-reactive protein, erythrocyte sedimentation rate, alpha1-acid glycoprotein, antithyroglobulin, antithyroperoxidase, TRAb, 25 hydroxyvitamin D (25OHD), dengue and zika IgG and IgM antibodies were also measured. Results. 30 CKV patients were included. Mean age was 59.1±15.7 years, 85% females and 77% Caucasian subjects. Disease duration comprised 4.9±4.0 months. Oligoarthritis was observed in 93% cases. Mean C-reactive protein levels were 10.1±6.8 ng/dL, erythrocyte sedimentation rate — 34.2±19.9 mm/1st hour and alpha1-acid glycoprotein 115.5±52.6 mg/dL. Intramuscular betamethasone depot single dose injection was administered in 54%, prednisone — in 15% and methotrexate — in 23% cases. Importantly, 1/30 (3.3%) cases was positive for ANA, 4/30 (13.3%) — for RF and none was positive for anti-CCP or any other autoantibodies. Complement and immunoglobulin levels were all within the normal range. Low levels of 25OHD were observed in 88% cases.
Study of features of humoral immune response to the new coronavirus infection COVID-19 among healthcare workers
Authors: Reshetnikova I. D. , Tyurin Yu. A. , Agafonova E. V. , Kulikov S. N. , Gilyazutdinova G. F. , Lopushov D. V. , Shaуkhrazieva N. D. , Isaeva G. Sh. , Ziatdinov V. B.
Published: November 2021

Relevance. Since the beginning of the epidemic in China, there have been reports of nosocomial cases of SARSCoV-2 infection, including among medical workers. Studies of the intensity of humoral immune response to the SARSCoV-2 virus among medical workers who are much more likely to have professional contact with COVID-19 patients than are of particular importance. The aim is to study the seroprevalence and features of the humoral immune response to SARS-CoV-2 among medical workers. Materials and methods. The study included 61 medical workers from a multidisciplinary hospital in Kazan, which was redesigned to provide medical care to patients with new coronavirus infection, using the method of random sampling. The control group consisted of 60 non-medical workers. For the determination of IgG, a solid-phase ELISA was used. Statistical processing of the results was carried out using MS Excel software. The error of the relative value (M±m) was calculated, and the 95% confidence interval of the frequency of occurrence. To assess the significance of differences, the Student’s test (t-test) was used for independent samples. Results. The proportion of those seropositive to SARS-CoV-2 in the study group was 45.9%, compared with 21.7% in the control group. Among medical workers seropositive to the SARS-CoV-2 virus, the proportion of asymptomatic forms was 18.5%, mild forms — 53.6%, moderate forms and severe forms 25%. Two forms of the formation of a humoral immune response among seropositive ones were revealed: the first is characterized by the gradual elimination of specific IgG antibodies to SARSCoV-2 after 8 weeks from the onset of the first symptoms of COVID-19, the second form is an increase in specific IgG to SARS-CoV-2 and a higher value of the coefficient level of IgM positivity to SARS-CoV-2 after 8–10 weeks from the onset of the first symptoms. The group of seropositive, “raising antibodies”, prevailed over the group of individuals “eliminating antibodies”. Among seropositive medical workers, two forms of the formation of a humoral immune response were revealed: synchronous with the parallel elimination of IgG and IgM antibodies and a parallel increase in IgG and IgM. Conclusion. The study of the level of humoral immunity to COVID-19 in medical workers is important in terms of planning both anti-epidemic measures and predicting the effectiveness of the response to vaccination to SARS-CoV-2.
Synthesis, crystal structure, and thermal stability of double borate Na3ErB2O6
Authors: Subanakov Alexey K. , Kovtunets Evgeniy V. , Bazarov Bair G. , Bazarova Jibzema G.
Published: November 2021

Double borate Na3ErB2O6 was synthesized by the solid-state reaction. The crystal structure of Na3ErB2O6 was refined by the Rietveld method: P21/c, a = 6.49775(14) Å, b = 8.50424(17) Å, c = 12.0067(3) Å, β = 118.4797(9)°, Z = 4. The crystal structure of Na3ErB2O6 consists of –[ErO6]∞-chains along the "b" axis, which are linked by BO3 triangles in a three-dimensional framework. Sodium atoms occupy empty positions inside the channels. The thermal behavior of Na3ErB2O6 was studied in detail in the range of 25–1150 °C range by DSC and TG methods. Na3ErB2O6 congruently melts at 1116 °C. Based on the results of DSC measurements, three reversible phase transitions were found for Na3ErB2O6.
Association of angiotensinogen and angiotensin II receptor type I polymorphisms with biomarkers of carbohydrate and lipid metabolism in Dagestan residents with type 2 diabetes and hypertension
Authors: Saidov M. Z. , Mammaev S. N. , Magadova G. M. , Balamirzoeva R. M. , Magomedova Z. Sh. , Magomedova Z. S. , Gamzaeva A. U.
Published: November 2021

Aim. To study the associations of angiotensinogen (AGT) (s4762(С521Т), rs699(Т704C)) and angiotensin II receptor type I (AGTR1) (rs5186(A1166C)) genetic polymorphisms with serum levels of insulin, glucagon, C-peptide, leptin, as well as with dyslipidemia and glycemic levels in Dagestan residents with combination of type 2 diabetes (T2D) and hypertension (HTN), as well as with isolated T2D/HTN.

Material and methods. We examined 16 patients with isolated T2D, 59 patients with T2D+HTN and 51 patients with isolated HTN from Dagestan. Genetic polymorphisms of the AGT and AGTR1 genes were studied. The levels of insulin, glucagon, C-peptide, and leptin were studied by enzyme-linked immunosorbent assay (ELISA), while lipid and carbohydrate metabolism — by biochemical methods.

Results. In patients with T2D, the association of CC genotype of AGT gene rs4762(С521Т) polymorphism with a leptin decrease was determined, while its CT genotype was associated with an increase in serum level of triglycerides. The TC genotype of AGT gene rs699(Т704C) polymorphism was associated with an increase in leptin, triglyceride and glucose levels. The AA genotype of AGTR1 gene rs5186(A1166C) polymorphism was associated with an increase in insulin and glucose levels, as well as a decrease in leptin level. In patients with a combination of T2D and HTN, CC and CT genotypes of AGT gene rs4762(С521Т) polymorphism was associated with a decrease in glucagon level. The TT genotype of AGT gene rs699(Т704C) polymorphism was associated with an increase in insulin, triglyceride, glucose and body mass index (BMI) levels. In isolated HTN, the CC and CT genotypes of AGT gene rs4762(С521Т) polymorphism were associated ith a decrease in glucagon level. The TT genotype of AGT gene rs699(Т704C) polymorphism was associated with increased levels of insulin, low density lipoproteins, and BMI.

Conclusion. Associations of AGT (s4762(С521Т), rs699(Т704C)) and AGTR1 (rs5186(A1166C)) genetic polymorphisms with carbohydrate and lipid metabolism changes are an important pathogenetic link of T2D and HTN, which allows developing an individual prognosis of these diseases in Dagestan residents.
Molecular genetic features of the development of restrictive cardiomyopathy in Russian children
Authors: Savostyanov K. V. , Basargina E. N. , Ryabova E. E. , Pushkov A. A. , Zhanin I. S. , Basargina E. Yu. , Alekseeva A. Yu. , Muraveva L. V. , Gandaeva L. A. , Fisenko A. P.
Published: November 2021

Aim. To identify the proportion of restrictive cardiomyopathy (RCM), as well as cardiomyopathy (CMP) with a restrictive type of hemodynamics among all cases of genetic CMP and to determine the relative frequencies and spectrum of nucleotide variants in Russian children with RCM, as well as to search for phenogenotypic correlations.

Material and methods. The study included 689 children with CMPs. All children underwent a molecular genetic testing of the target regions of 419 genes responsible for various cardiomyopathies and channelopathies using the method of massively parallel sequencing (MPS).

Results. In 668 (97,0%) children, pathogenic, likely pathogenic nucleotide variants, as well as nucleotide variants with unknown clinical significance, were identified. Of these, 45 (6,7%) patients were selected to determine the molecular genetic characteristics of RCM, 20 of whom had clinical symptoms and morphofunctional structure of RCMP (3,0%), while the remaining 25 (3,7%) children were diagnosed with another CMP type with a restrictive type of hemodynamics. In total, these patients had 41 nucleotide variants in 15 different genes, while 19 (46,3%) variants were pathogenic, 12 (29,3%) — likely pathogenic, 10 (24,4%) — uncertain clinical significance. Pathogenic and likely pathogenic variants were identified in a total of 38 (84,4%) patients, while in 19 (42,2%) patients, the pathogenic variants described earlier were found. The most common genetic marker of RCM in Russian children was TNNI3 gene mutations. In total, they were identified in 12 (25%) children: with RCP — 8 (40%) patients; with CMP with a restrictive type of hemodynamics — 4 (16%) patients. At the same time, the most common mutation of the TNNI3 gene was the nucleotide variant c.575G>A, leading to the amino acid variant p.R192H, described earlier in patients with RCM and identified by us in three (15%) unrelated children with RCM. In addition, a significant difference was found between the averaged values of N-terminal pro-brain natriuretic peptide in patients with mutations in the MYH7 and TNNI3 genes (0,0039, p<0,05), as well as between the peak flow gradient values in children with mutations in TNNI3 and FLNC genes (0,0016, p<0,05), TNNI3 and MYH7 genes (0,039, p<0,05).

Conclusion. The results of this study indicate a significant genetic heterogeneity of RCM in Russian children and the need for further research aimed at finding genotype-phenotype associations in order to predict the course of the disease and select the proper therapy.
Genetic risk factors for dilated cardiomyopathy
Authors: Vaikhanskaya T. G. , Sivitskaya L. N. , Levdansky O. D. , Kurushko T. V. , Danilenko N. G.
Published: November 2021

Aim. To study the diagnostic significance of genetic testing in patients with dilated cardiomyopathy (DCM), identify predictors of life-threatening ventricular tachyarrhythmias (VTAs) and assess adverse clinical outcomes in different genetic groups.

Material and methods. The study included 126 unrelated patients with verified DCM as follows: 70 (55,6%) probands with criteria for familial DCM and 56 (44,4%) individuals with a probable hereditary component. All patients (age, 43,1±11,3 years; men, 92 (73%); left ventricular ejection fraction, 30,6±8,43%; left ventricular enddiastolic diameter, 68,3±8,36 mm; follow-up period — median, 49 months) receive a complex of diagnostic investigations, including genetic screening using nextgeneration sequencing, followed by verification of variants by the Sanger method.

Results. Pathogenic and likely pathogenic genetic variants were found in 61 (48,4%) of 126 patients with DCM. The dominant mutations were titin-truncating variants (TTNtvs), identified in 16 individuals (12,7%), and variants of lamin A/C (LMNA), identified in 13 probands (10,3%). Mutations in the other 19 genes were found in 32 (25,4%) patients. The following primary endpoints were assessed: sudden cardiac death (SCD), episodes of VTA (sustained ventricular tachycardia/ventricular fibrillation) and appropriate shocks of implanted cardiac resynchronization therapy (CRT)/cardioverter defibrillators (CVD) devices. As a result of ROC analysis, the following independent risk factors for SCD were identified: mutations in the LMNA gene (AUC, 0,760; p=0,0001) and non-sustained ventricular tachycardia (cut-off heart rate ≥161 bpm: AUC, 0,788; p=0,0001). When comparing the phenotypes and genotypes of DCM, TTNtv genotype was associated with a lower prevalence of complete left bundle branch block (χ2=7,46; p=0,024), a lower need for CRT/CVD implantation (χ2=5,70; p=0,017) and more rare episodes of sustained ventricular tachycardia/ventricular fibrillation (χ2=30,1; p=0,0001) compared with LMNA carriers. Kaplan-Meier analysis showed the worst prognosis in carriers of LMNA mutations both in relation to life-threatening VTA (log rang χ2=88,5; p=0,0001) and in achieving all unfavorable outcomes (χ2=27,8; p=0,0001) compared with groups of genenegative individuals, carriers of TTNtv and other genotypes.

Conclusion. The phenotypes of DCM with TTNtv did not significantly differ in the incidence of VTAs and adverse outcomes compared with the gene-negative group and other genotypes (with the exception of LMNA). The contribution of the associations of LMNA mutations with VTAs on prognosis was confirmed, which shows the important role of LMNA genotype diagnosis for SCD risk stratification in patients with DCM.
Predictive factors of cardiovascular changes depending on the type and intensity of physical activity in professional athletes
Authors: Garganeeva N. P , Taminova I. F. , Kalyuzhin V. V. , Kalyuzhina E. V , Smirnova I. N.
Published: November 2021

Aim. To determine the early predictive factors of cardiovascular changes in professional athletes, depending on the type and intensity of physical activity.

Material and methods. A total of 136 male athletes were examined. Of these, 116 were professional athletes (age, 22,07±4,1 years) as follows: freestyle wrestling, judo (n=30), cross-country skiing, biathlon (n=27), powerlifting (n=33), volleyball (n=26). Control group included 20 athletes (age, 17,95±1,5 years) with a history of training less than 3 years. All participants underwent electrocardiography (ECG), echocardiography, cycle ergometry (CE) with assessment of physical performance at a heart rate of 170 bpm (PWC170) and maximum oxygen consumption (MOC). When creating predictive models of early cardiovascular changes, we used logistic regression, stepwise regression and Wald statistics. Differences were considered significant at p<0,05.

Results. Predictive models of logistic regression using ROC analysis showed high sensitivity and specificity, a high percentage of correct predictions using data from echocardiography — 86,8%, CE — 80,9%, ECG and other indicators — 83,1%. A stepwise algorithm was used to select prognostic factors determining early cardiovascular changes in young athletes, depending on the stage of sports training, the intensity and type of dynamic and/or static exercise: left ventricular posterior wall thickness (p=0,008), left ventricular mass (p=0,001), stroke volume (p=0,002), end-systolic volume (p=0,001), PWC170 (p=0,025), MOC (p=0,003), recovery time of heart rate (HR) (p=0,029) and blood pressure (p=0,032) after submaximal exercise on a cycle ergometer, body mass index (p=0,029), heart rate (p=0,034), office systolic blood pressure (p=0,009), intraventricular (bundle) block (p=0,046), left ventricular repolarization abnormalities (p=0,010), mild cardiac connective tissue anomalies (p=0,035).

Conclusion. The early prognostic factors established by the logistic regression affect the characteristics and risk of cardiovascular changes in each group of young athletes. This demonstrates the need to develop individual medical support programs, further monitoring, evaluation, correction and prevention of identified disorders, taking into account the type of sports, intensity and exercise.
Experience in genetic testing of hypertrophic cardiomyopathy using nanopore DNA sequencing
Authors: Salakhov R. R. , Golubenko M. V. , Pavlukova E. N. , Kucher A. N. , Babushkina N. P. , Valiahmetov N. R. , Markov A. V. , Belyaeva E. O. , Kanev A. F. , Nazarenko M. S.
Published: November 2021

Aim. To investigate the application of the Oxford Nanopore Technologies’ third generation sequencing for the genetic testing of hypertrophic cardiomyopathy.

Material and methods. The study involved 12 patients with hypertrophic cardiomyopathy aged 18 to 67 years (women, 9; men, 3). Using the PCR barcoding amplicons (SQK-LSK109) protocol, DNA libraries were created which contained long-range PCR fragments of the MYH7, MYBPC3, TNNT2, TNNI3 and TPM1 genes. The sequencing was performed using the MinION system by Oxford Nanopore Technologies (UK). Bioinformatic algorithms for data analysis included Guppy v.5.0.7, Nanopolish and Clairvoyante. The identified genetic variants were confirmed by Sanger sequencing.

Results. Data on the complete sequence of the five major sarcomeric genes for hypertrophic cardiomyopathy were obtained. We found eight potentially disease-causing sequence variants in MYH7, MYBPC3 and TNNT2 genes by monomolecular sequencing. However, only three mutations p.Arg243Cys, p.Tyr609Asn, p.Arg870His in the MYH7 gene, and one mutation p.Lys985Asn in the MYBPC3 were confirmed by Sanger sequencing. Cascade screening of pathogenic variant p.Arg870His in the MYH7 gene was performed. We found one asymptomatic carrier.

Conclusion. It appears that monomolecular sequencing technology is a feasible approach to identify mutations in patients with hypertrophic cardiomyopathy. Although improvement in accuracy of DNA sequencing, as well as optimization and simplification of bioinformatic algorithms for identification of the genetic variants are needed.
Spectrum of desmosomal gene variations in patients with arrhythmogenic right ventricular cardiomyopathy
Authors: Shestak A. G. , Blagova O. V. , Lutokhina Yu. A. , Dzemeshkevich S. L. , Zaklyazminskaya E. V.
Published: November 2021

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a hereditary myocardial disease with a high risk of sudden cardiac death. The most common genetic forms of the disease are associated with desmosomal gene mutations.

Aim. To study the prevalence of desmosomal forms of ARVC and to analyze variations in the PKP2, DSG2, DSP, DSC2 and JUP genes in a sample of Russian patients with ARVC.

Material and methods. Included patients with ARVC underwent resting electrocardiography (ECG), 24-hour Holter ECG monitoring, echocardiography, chest x-ray, myocardial biopsy (if indicated), contrast-enhanced cardiac magnetic resonance imaging. All patients underwent medical genetic counseling. Mutations in the PKP2, DSG2, DSP, DSC2, and JUP genes was detected using highthroughput sequencing on the IonTorrent platform, followed by Sanger sequencing of uncovered gene regions. The pathogenicity of identified genetic variations was assessed according to modern guidelines.

Results. ARVC was established in 80 Russian unrelated patients. More than half of the probands (57%) in the study sample had definite diagnosis of ARVC, while 30% and 13% — borderline and possible ARVC, respectively. A positive family history of heart disease and/or SCD was noted in 30%. Genetic variants of pathogenicity class IV-V were detected in 15 (18,75%) probands in the PKP2, DSG2, DSP genes. The detection of genetic variants of pathogenicity class IV-V was different in the subgroups of patients with varying degrees of diagnosis reliability: 13 probands (28,3%) in the subgroup with definite ARVC and 2 probands (8,3%) in the subgroup with borderline ARVC. No genotype-positive probands were found in the subgroup with possible ARVC. Variations of unknown clinical significance were found in 13 (16,25%) probands.

Conclusion. The diagnostic yield of the desmosomal genes PKP2, DSG2, DSP, DSC2, and JUP was 19% with initial diagnosis of ARVC. The detection of mutations was significantly higher in patients with definite ARVC and severe disease manifestations.
Influence of standard heart failure therapy on readmission rate: opportunities and limitations in modern clinical practice
Authors: Gilyarevsky S. R.
Published: November 2021

This review considers the clinical and epidemiological significance of hospitalizations for decompensated heart failure, as well as using it as an indicator of therapy effectiveness. The data on the frequency of using medications that reduce the hospitalization risk in randomized clinical trials and in real practice are presented. The reasons for inadequate prescription of drugs for the treatment of heart failure with reduced ejection fraction and their use in insufficient doses, which include therapeutic inertness and physiological limitations, as well as the need to introduce drugs with alternative mechanisms of action into clinical practice, are iscussed.
Antithrombotic effect of different acetylsalicylic acid drug formulations: is there a difference?
Authors: Sidorov A. V.
Published: November 2021

To date, a sufficient volume of clinical studies has been accumulated that have demonstrated a reduced antiplatelet effect of enteric-coated (EC) lowdose acetylsalicylic acid (ASA). Delayed and incomplete absorption from the intestinal alkaline medium, which significantly reduces the bioavailability of drug, is considered the main reason for laboratory aspirin resistance (pseudoresistance) to EC ASA. This phenomenon is of particular importance for patients with acute coronary syndrome, when a quick effect is required, as well as for patients with diabetes and obesity due to additional causes of increased platelet activity, on the one hand, and reduced bioavailability of ASA, on the other. Given the issue of efficacy, the dubious gastroprotective effect and the more pronounced damaging effect on the mucous membrane of small intestine, the use of EC ASA should be avoided, especially in patients with a multifactorial risk of insufficient response to therapy. A good alternative is buffered ASA, which quickly dissolves and is partially absorbed directly in the stomach, having antiplatelet activity comparable to simple ASA and a similar aspirin resistance, is associated with a lower risk of aspirin-induced enteropathy in comparison with ES ASA. In addition, according to a number of small studies and retrospective analyzes, buffered ASA is less likely to cause damage to gastric mucosa compared to EC ASA.
Variant of the FLNC gene nucleotide sequence in a family with different phenotypic manifestations of left ventricular non-compaction
Authors: Kulikova O. V. , Myasnikov R. P. , Meshkov A. N. , Kudryavtseva M. M. , Mershina E. A. , Kiseleva A. V. , Divashuk M. G. , Kharlap M. S. , Koretsky S. N. , Sinitsyn V. E. , Drapkina O. M.
Published: November 2021

Left ventricular non-compaction is a heterogeneous heart disease with various phenotypic and clinical manifestations. The article presents the results of clinical, instrumental and molecular genetic investigations of a family with diagnosed left ventricular non-compaction (LVNC) with different clinical and phenotypic manifestations. As a result of a molecular genetic testing, all family members with the LVNC phenotype were found to have a likely pathogenic variant in the FLNC gene. Variants in this gene are associated with a number of cardiomyopathies: dilated, hypertrophic, and restrictive. In the international scientific literature, isolated clinical cases of LVNC development with variants of the FLNC gene nucleotide sequence are presented. In our work, we present a case report of LVNC with a variety of clinical manifestations within the same family.
Story reading with incidental comprehension and memory: left hemisphere dominance
Authors: Vigliecca Nora Silvana
Published: November 2021

ABSTRACT Background: There are no studies on adults with unilateral brain lesions regarding story reading with incidental/implicit comprehension and memory, in which memory is only assessed through delayed recall. There is a need for validation of cerebral laterality in this type of verbal recall, which includes spontaneous performance (free or uncued condition (UC)), and induced-through-question performance regarding the forgotten units (cued condition (CC)). Objectives: To explore the effects of unilateral brain lesions, of oral reading with expression (RE) and comprehension (RC) on delayed recall of a story, as either UC or CC; and to validate the ability of UC and CC to discriminate the side of brain injury. Methods: Data were obtained from 200 right-handed volunteers, among whom 42 had left-hemisphere injury (LHI), 49 had right-hemisphere injury (RHI) and 109 were demographically-matched healthy participants (HP). Patients who were unable to read, understand or speak were excluded. Results: LHI individuals presented impairment of both UC and CC, in relation to the other two groups (non-LHI) with sensitivity and specificity above 70%. LHI and RHI individuals were not significantly different in RE and RC, but they were both different from HP in all the assessments except CC, in which RHI individuals resembled HP. Despite this lack of abnormality in RHI individuals during CC, about half of this group showed impairment in UC. Additionally, whereas RE had a significant effect on UC, the moral of the story (RC) had a significant effect on both UC and CC. Conclusions: The left hemisphere was dominant for this memory task involving implicit processing.
Immunosuppressors and immunomodulators in Neurology - Part I: a guide for management of patients underimmunotherapy
Authors: Abrantes Fabiano Ferreira , Moraes Marianna Pinheiro Moraes de , Albuquerque Filho José Marcos Vieira de , Alencar Jéssica Monique Dias , Lopes Alexandre Bussinger , Pinto Wladimir Bocca Vieira de Rezende , Souza Paulo Victor Sgobbi de , Oliveira Enedina Maria Lobato de , Oliveira Acary de Souza Bulle de , Pedroso José Luiz , Barsottini Orlando Graziani Povoas
Published: November 2021

ABSTRACT For patients with autoimmune diseases, the risks and benefits of immunosuppressive or immunomodulatory treatment are a matter of continual concern. Knowledge of the follow-up routine for each drug is crucial, in order to attain better outcomes and avoid new disease activity or occurrence of adverse effects. To achieve control of autoimmune diseases, immunosuppressive and immunomodulatory drugs act on different pathways of the immune response. Knowledge of the mechanisms of action of these drugs and their recommended doses, adverse reactions and risks of infection and malignancy is essential for safe treatment. Each drug has a specific safety profile, and management should be adapted for different circumstances during the treatment. Primary prophylaxis for opportunistic infections and vaccination are indispensable steps during the treatment plan, given that these prevent potential severe infectious complications. General neurologists frequently prescribe immunosuppressive and immunomodulatory drugs, and awareness of the characteristics of each drug is crucial for treatment success. Implementation of a routine before, during and after use of these drugs avoids treatment-related complications and enables superior disease control.
Encontros narrativos: mulheres pesquisadoras em meio à pandemia
Authors: Dellbrügger Ana Paula , Oliveira Mariel Corrêa de , Guerra Camilla Rodrigues , Scaramussa Claudia Schramm , Zorzi Joice Guerra , Ricci Éllen Cristina , Dimov Tatiana
Published: November 2021

RESUMO A pandemia de Covid-19 gerou uma grave ruptura do cotidiano, submetendo as pessoas ao distanciamento e ao isolamento social e exigindo o desempenho de diversos papéis ocupacionais em um só ambiente. Diante disso, 11 mulheres de 2 universidades federais se uniram para fazer ciência e produzir grupos de ajuda e suporte mútuo virtuais para a população de 6 públicos-alvo diferentes. Neste artigo, apresenta-se uma reflexão sobre os caminhos percorridos pelas autoras a partir de aspectos semelhantes e singulares, dificuldades e privilégios identificados que perpassam suas vidas. Recorreu-se à cartografia para desenvolver este texto pela possibilidade de romper a lógica positivista acadêmica e expressar sentimentos e subjetividades. Entendendo tal experiência como irreprodutível pela técnica, construíram-se narrativas a partir da pergunta: “Como a minha história, constituindo-se mulher, afeta a minha participação nesta atividade de pesquisa?”. Depois das leituras, elencaram-se oito categorias de análise e inferiu-se que gênero, raça/etnia e classe podem ser privilégios ou obstáculos a depender da sua expressão: masculino/ feminino, branco/negro, alta/baixa. Para as mulheres, a divisão sexual e a dupla jornada de trabalho, assim como a maternidade, ampliam a desvantagem causada pelo gênero.
Como que as mudanças nas taxas de mortalidade e expectativa de vida afetam a projeção da população idosa no estado de São Paulo?
Authors: Brusse Gustavo Pedroso de Lima
Published: November 2021

Resumo Introdução O Brasil experimentou, ao longo do século XX, uma profunda mudança em relação à expectativa de vida ao nascer. Nesse processo, foi importante não somente a queda do nível da mortalidade para o grande aumento da expectativa de vida, mas também a mudança no padrão da mortalidade. Recentemente, vêm sendo discutidas mudanças no padrão de mortalidade nas idades mais avançadas, bem como o impacto no envelhecimento populacional. Entretanto, no Brasil, as discussões sobre a longevidade e o comportamento da mortalidade nas idades avançadas ainda são incipientes. Especialistas sugerem que projeções de mortalidade incorporem novas tendências de desaceleração da mortalidade em idades avançadas e explorem abordagens de coortes para suas formulações de tendências. Objetivo Estudar o efeito causado pelas mudanças no comportamento da mortalidade e da expectativa de vida na predição do tamanho da população idosa do estado de São Paulo. Método Método estendido de coortes componentes. Resultados Alterações no nível e no padrão da mortalidade têm um efeito maior na predição da população de 80 anos ou mais em comparação com a população de 60 anos ou mais. Ademais, considerar o gap da expectativa de vida entre os sexos é relevante para determinar o número futuro de idosos. Conclusão Ao utilizar países em diferentes estágios da transição epidemiológica como cenário futuro do padrão e do nível da mortalidade de São Paulo, o método estendido de coortes componentes se torna uma possibilidade metodológica interessante para avaliar o impacto dessas modificações para a projeção da população idosa, podendo ser uma ferramenta para a avaliação de políticas públicas.
Herramientas conceptuales para contrarrestar la patologización trans en la formación de Psicología en Argentina
Authors: Maruzza Corina
Published: November 2021

Resumen Este trabajo argumenta que es urgente detener y revertir la patologización de las experiencias trans en la formación de psicología en Argentina. Para el abordaje de este problema, se presenta una propuesta basada en la combinación de dos enfoques teóricos: el de la salud mental comunitaria y el de los estudios trans. A partir de esta articulación, se propone, en primer término, realizar una lectura crítica que de cuenta del rol fundamental que la formación de psicología continúa teniendo con respecto a la patologización trans en Argentina. Y, en segundo término, introducir en la formación de psicología, aquellos conceptos provenientes del campo de los estudios trans que pueden realizar aportes muy significativos al campo de la salud mental para la comprensión adecuada de las experiencias trans. Se toma como caso de análisis un texto de orientación psicoanalítica de reciente publicación en este país. Y se presentan tres herramientas conceptuales en particular: escucha, transfobia y performatividad de género, tal como son planteadas en los desarrollos teóricos de Leila Dumaresq, Miquel Missé y Susan Stryker, respectivamente.
Territorialidades, desplazamientos, performatividades de géneros y sexualidades: juventudes LGBTQIA+ en las áreas suburbanas de la ciudad de São Paulo, Brasil
Authors: Unsain Ramiro Fernandez , Couto Marcia Thereza , Zucchi Eliana Miura , Ferraz Dulce Aurélia de Souza , Escorse Moira , Silveira Regis Alves , Grangeiro Alexandre
Published: November 2021

Resumen El estudio discute la relación entre territorialidades/espacialidades periféricas y las configuraciones de las expresiones de géneros y sexualidades de jóvenes LGBTQIA+ en el área suburbana de la ciudad de São Paulo, Brasil. El método etnográfico contempló varias estrategias de producción de datos en tres etapas entre 2019 e 2020. Los procesos de apropiación territorial/espacial a partir de agregados LGBTQIA+ son distribuidos en archipiélagos espacio-territoriales propicios (y aparentemente seguros) para sociabilizar y re-reproducir pertenencias. El diálogo entre espacio y territorio mediado por las sexualidades y los géneros a partir de sus expresiones identitarias mostró ser un camino fecundo para articular posibilidades de implementar políticas públicas en vista de intentar mitigar las lagunas que existen con relación a la prevención del VIH entre jóvenes LGBTQIA+ en un espacio/territorio específico.
“É tudo uma máfia”: trânsitos e tensões na busca de um lugar no palco
Authors: Mascarenhas Neto Rubens
Published: November 2021

Resumo Este artigo explora relações e constrangimentos envolvendo as oportunidades de shows e de progressão na carreira de drag queens iniciantes. Através da análise de material etnográfico, persigo a categoria máfia que, quando empregada, lança suspeita sobre resultados de concursos e a oferta de oportunidades. Seu uso sugere a elevada competitividade no meio artístico drag. Analiso ainda um momento específico durante a pesquisa de campo no qual fui convidado a julgar um concurso. A metodologia consiste em pesquisa etnográfica, observação participante e conversas informais. A pesquisa foi realizada entre 2015 e 2017, tendo como foco o processo de constituição das carreiras artísticas de um grupo de jovens drag queens que, desde Campinas, buscam viabilizar sua participação em concursos e shows para além da cidade.
Placer y cuerpo femenino: discursos en el contexto de la educación sexual institucionalizada en Medellín
Authors: Cataño María Paulina López
Published: November 2021

Resumen La investigación buscó explorar y analizar las concepciones que sobre el placer y el cuerpo tienen profesionales que implementan programas o proyectos de educación sexual en la ciudad de Medellín. Se realizó una investigación de corte cualitativo, utilizando la técnica de entrevista-semiestructurada con 9 participantes, y posterior análisis de datos desde el análisis crítico del discurso. Los resultados permitieron evidenciar un tratamiento diferencial del cuerpo y la sexualidad de las mujeres, anclado a una concepción del cuerpo y el placer en tres categorías principales; Cuerpo como templo y placer como peligro, Cuerpo como máquina y placer como mecanismo de evolución, y Cuerpo como objeto del cuidado y placer como objeto de control. Partiendo del concepto de dispositivo de la sexualidad de Foucault (1977), la propuesta de concepción del cuerpo de Butler (2002) y la psicología social feminista de Haraway (1991), se realiza un análisis crítico del discurso que permite develar las contradicciones y dilemas presentes en los discursos y las implicaciones de estas concepciones del placer y el cuerpo femeninos dentro de la educación sexual institucionalizada.
Dinâmica econômica e imobiliária: periodização dos macrodeterminantes dos anos 2000 e 2010
Authors: Mioto Beatriz Tamaso
Published: November 2021

Resumo O objetivo deste artigo é propor uma periodização dos macrodeterminantes do desenvolvimento imobiliário no Brasil nas décadas de 2000 e 2010. Este exercício busca articular as dimensões macroeconômica, setorial e institucional e organizar variáveis que ajudem na interpretação dos fenômenos econômicos que influenciam a produção do espaço. Os períodos analisados são: 2003-2008, de aceleração e mudança estrutural do mercado imobiliário; 2009-2011, de auge do setor imobiliário, especialmente a partir das políticas anticíclicas; 2012-2014, de desaceleração da dinâmica de acumulação do País, em geral, e do imobiliário, em particular; 2015-2019, de crise e estagnação da economia nacional com efeitos severos para o imobiliário. Assim, busca-se sintetizar, através da periodização, uma série de análises que se encontram, em geral, dispersas na literatura.
O setor imobiliário habitacional pós-2015: crise ou acomodação?
Authors: Faustino Raphael Brito , Royer Luciana de Oliveira
Published: November 2021

Resumo O artigo busca analisar os ciclos de expansão, estabilidade e retração do mercado imobiliário nas duas últimas décadas. Para tal, faz uso dos dados referentes ao financiamento imobiliário no âmbito do Sistema Financeiro de Habitação (SFH) e do Programa Minha Casa Minha Vida, principal programa habitacional no período entre 2003 e 2020. A partir dos indicadores apresentados, considera que os ciclos do mercado imobiliário dependem, em grande medida, das transformações ocorridas na política macroeconômica adotada no País, que acabam por afetar as políticas públicas e o padrão de demanda por crédito imobiliário. É, contudo, no período de retração que os agentes do mercado imobiliário pressionam por modificações na regulação do setor, que tendem a impactar o próximo ciclo de expansão.
O e-commerce e os fundos imobiliários logísticos: estratégias de captura de rendas imobiliárias
Authors: Magnani Maira , Sanfelici Daniel
Published: November 2021

Resumo O volume de recursos direcionados para o mercado imobiliário comercial cresceu rapidamente nos últimos anos com o advento da financeirização. Neste trabalho, examinamos o processo de financeirização do setor logístico brasileiro, argumentando que ele está relacionado com a atuação de fundos de investimento imobiliário. Procuramos mostrar que esses atores financeiros desenvolveram estratégias de extração de rendas imobiliárias se aproveitando de dois processos concomitantes: de um lado, a crescente demanda de empresas varejistas por espaços logísticos – acelerada com a pandemia da Covid-19 –; e, de outro, da procura dos investidores brasileiros por investimentos tidos como “alternativos”. Concluímos que esses atores possuem critérios particulares de risco e retorno que resultam em investimentos altamente seletivos, tanto em localização, como em características construtivas e de escolha de locatários.
A oferta residencial na retração imobiliária da metrópole paulistana nos anos 2000
Authors: Castro Carolina Maria Pozzi de , Sígolo Letícia Moreira
Published: November 2021

Resumo A análise identifica mudanças e continuidades no comportamento da oferta residencial na retração imobiliária da Região Metropolitana de São Paulo nos anos 2000. Estrutura-se uma periodização, considerando movimentos macroeconômicos e seus impactos no setor imobiliário. Observam-se dinâmicas baseadas em subtipos de mercado e vetores de expansão da oferta, refletindo especificidades e rugosidades no território metropolitano, além das características dos lançamentos e sua precificação balizada nos financiamentos disponíveis e estratégias de maximização de ganhos dos incorporadores. Verifica-se um reposicionamento do setor em que o mercado da Capital assume centralidade nas estratégias que regionalmente contrarrestam a crise com oferta importante de produtos econômicos e alterações nos padrões, apoiada no Programa Minha Casa Minha Vida, mediante crescente participação de grandes empresas.
Prevalence of malocclusion in early childhood and its associated factors in a primary care service in Brazil
Authors: Pegoraro Natalia de Abreu , Santos Camila Mello dos , Colvara Beatriz Carriconde , Rech Rafaela Soares , Faustino-Silva Daniel Demétrio , Hugo Fernando Neves , Hilgert Juliana Balbinot
Published: November 2021

ABSTRACT Purpose to evaluate the prevalence of malocclusion and its associated factors of children cared for by a PHC Service in Porto Alegre, Brazil. Methods a cross-sectional study nested in a cohort, carried out in 12 Health Care Practices. Of the 414 children in the cohort examined, 268 were assessed for malocclusion. The presence of anterior open bite, posterior and anterior crossbite was evaluated by the criteria of Foster and Hamilton. Socioeconomic variables, breastfeeding habits and pacifier use information were collected through a standardized questionnaire. Data analysis was performed using a hierarchical approach by Poisson Regression with robust variance. Results out of the total 268 evaluated, 135 (50.4%) were boys, and the average age was 28.6 (± 11.9) months. Out of the 143 (53.4%) cases of malocclusion, 113 were anterior open bite, 16 were anterior crossbite, 27 were posterior crossbite, and 38 had increased overjet. In the final analysis, it was observed that there was a higher prevalence of malocclusion in children who never breastfed (PR = 1.44; 95%CI 1.00-2.08) and who always used a pacifier to sleep (PR = 1.81; 95%CI 1.14-2.86). Conclusion the prevalence of malocclusion in this population was high and was associated with behavioral habits, such as the use of pacifier and not breastfeeding.
Dificuldade no aleitamento materno exclusivo no alojamento conjunto: revisão integrativa
Authors: Bicalho Carine Vieira , Martins Camila Dantas , Friche Amélia Augusta de Lima , Motta Andréa Rodrigues
Published: November 2021

RESUMO Objetivos Identificar e analisar os estudos que avaliaram as dificuldades enfrentadas pelas puérperas para implementação do aleitamento materno exclusivo até 72 horas após o parto, durante o período em que permaneceram no alojamento conjunto. Estratégia de pesquisa Foi realizada busca de artigos nas plataformas PubMed, BVS e SciELO. Critérios de seleção Foram selecionados artigos originais, com resumo disponível, publicados entre os anos de 2010 e 2020, em português, inglês ou espanhol, que investigaram as dificuldades observadas no aleitamento materno exclusivo durante o período em que a díade mãe/bebê permaneceu no alojamento conjunto. Resultados A amostra final consistiu em 11 artigos publicados entre os anos de 2010 e 2019, sendo o Brasil o país com maior número de publicações. O tamanho das amostras nos estudos variou de 40 a 1.691 puérperas, com faixas etárias entre 13 e 46 anos. Observou-se prevalência de amamentação na primeira hora após o nascimento entre 43,9% e 77,3%. Conclusão A maioria dos artigos indicou que a principal dificuldade no aleitamento materno no período pós-parto se refere aos traumas mamilares. Os traumas mamilares são ocasionados por características do aleitamento, da mulher, da mama, da gestação, do parto e da rede de apoio da puérpera.
Acreditação Institucional de Ouvidorias do SUS: uma análise das experiências iniciais de avaliação externa
Authors: Venâncio de Siqueira Sandra Aparecida , Bessa Fernandes Fernando Manuel , Tavares Motta Caio , Da Conceição Cunha Wanzeler Murilo , Jardim Motta José Inácio , Da Silva Santos José Antônio
Published: November 2021

Com base no curso de Qualificação de Avaliadores Externos para o processo de Acreditação no SUS, realizado em 2018, o objetivo deste artigo é discutir os desafios postos ao processo de formação destes avaliadores, com base em uma perspectiva da avaliação participativa, como forma de contribuir para aperfeiçoamento de processos dos dispositivos de avaliação externa e autoavaliação. Para isso, analisou-se 33 documentos produzidos com a prática destes dispositivos, no âmbito do Projeto. Na avaliação externa, o principal desafio consiste em ‘olhar para o outro’; este tipo específico de olhar exige que a Equipe de Avaliação Externa detenha o domínio sobre os conhecimentos prévios, competências e atitudes necessárias ao trabalho, para captar saberes, intencionalidades e relações, expressas nos atos de fala dos sujeitos. Na autoavaliação, o principal desafio consiste em ‘olhar para si’; tomar a si próprio como objeto de conhecimento e campo de transformação requer formas específicas de fazer, visando o ganho de qualidade nos processos de trabalho. Construir uma cultura de avaliação, em que as informações produzidas subsidiem a tomada de decisão é um desafio para as ouvidorias, que pode ser superado com o Referencial de Qualidade das Ouvidorias do SUS.
New and little known species of moth flies (Diptera: Psychodidae: Psychodinae) from Nicaragua
Authors: Ježek Jan , Oboňa Jozef , Le Pont François , Manko Peter , Maes Jean-Michel
Published: November 2021

The male of a new species Arisemus venustus sp. n. from Nicaragua, the Cerro Musun Natural Reserve, is described. A. atrasetus (Rapp, 1945) and Platyplastinx tango Quate et Brown, 2004 (Diptera: Psychodidae: Psychodinae) from Nicaragua are redescribed and illustrated on the basis of male morphological characters.
Density Functional Theory Study of the Adsorption of Oxygen and Hydrogen on 3d Transition Metal Surfaces with Varying Magnetic Ordering
Authors: Peck Mogamat A. , Santos-Carballal David , de Leeuw Nora H. , Claeys Michael
Published: November 2021

ABSTRACT We have employed density functional theory (DFT) calculations to investigate the adsorption of molecular oxygen and hydrogen on 3d transition metal (TM) surfaces with varying ordered magnetic structures in the bulk, namely ferromagnetic Fe(110), Co(0001), Ni(111) and diamagnetic Cu(111). The trend observed in the energies of adsorption was compared with the magnetic moment of the cell using the d-band centre model of chemisorption and the Stoner model of magnetic energy. As the gap between the d-band centre and the Fermi level of the TM decreases, more antibonding orbitals are present above the Fermi level and thus unoccupied, leading to stronger binding. Correspondingly, the shift in the d-band centre decreases the density of states (DOS) at the Fermi level giving rise to the ordered magnetic structure. Keywords: d-Band centre, chemisorption, Hedvall effect, magnetism.
New combinations in Chondrosum (Poaceae)
Authors: Shaw Robert B. , Wipff Joseph K.
Published: November 2021

The following new combinations in Chondrosum are made: Chondrosum barbatum (Lag.) W. Clayton var. rothrockii (Vasey) R.B. Shaw & J.K. Wipff; Chondrosum ramosum (Scribn. ex Vasey) R.B. Shaw & J.K. Wipff; Chondrosum trifidum (Thurb.) Clayton var. burkii (Scribn. ex Watson) R.B. Shaw & J.K. Wipff.
What is Sambucus mexicana (Adoxaceae)?
Authors: Whittemore Alan T.
Published: November 2021

Inconsistent application of the name Sambucus mexicana C. Presl ex DC. has resulted in confusion in the literature and in herbaria. In order to determine the correct application of the name, Presl’s original material (a Haenke collection, made on the Malaspina Expedition) was located and characterized. It matches plants from the area around Monterey, California, where Haenke did much collecting, and clearly differs from Sambucus taxa in other parts of North America. The name S. mexicana must be applied to plants from California and adjacent areas, as has been done by most authors, not to plants from central Mexico, as in a few recent references. A lectotype is designated for the species.
Aglaonema nebulosum (Araceae), range extension and first record from India
Authors: Singh Bikarma , Adhikari Dibyendu , Barik Saroj Kanta
Published: November 2021

Aglaonema nebulosum N.E.Br., Araceae is reported here for the first time from India based on unreported three collections from Urmasi, Nongtrai and Tyrna villages in Meghalaya, northeastern India. The species can be recognized by the oblanceolate to narrowly ellipticoblong leaves with entire margin, the membranous linear cataphylls inflorescence and dark red matured fruits in the form berry. Based on the population status and trend, the species was classified as Critically Endangered.
Phyllanthus debilis (Phyllanthaceae) newly reported for North America
Authors: Levin Geoffrey A. , Wilder George J. , McCollom Jean M.
Published: November 2021

Herein, Phyllanthus debilis J.G. Klein ex Willd. (Phyllanthaceae), a species apparently native to the Indian subcontinent, is newly reported for North America. The present report brings to 17 the number of Phyllanthus species known from North America north of Mexico.