bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGARUH KEPEMIMPINAN TRANSFORMASIONAL KEPALA SEKOLAH DAN BUDAYA SEKOLAH TERHADAP KINERJA GURU DI SMA NEGERI SUB RAYON 04 KOTA PONTIANAK
Authors: B2041142030 Jasmiardi -
Published: December 2020

Penelitian ini bertujuan untuk mengetahui ada tidaknya pengaruh yang signifikan antara kepemimpinan transformasional dan Budaya sekolah SMA Negeri Sub Rayon 04 Kota Pontianak terhadap Kinerja guru Dalam Melaksanakan Administrasi Pembelajaran, baik secara parsial maupun bersama-sama.Penelitian ini berbentuk kuantitatif dengan metode deskriptif menggunakan rancangan studi korelasional Penelitian ini dilaksanakan pada Sekolah Tinggi Kesehatan sekota pontianak, dengan menyebarkan angket terhadap 140 orang Guru sebagai sampel.Hasil analisis disimpulkan bahwa (1) bahwa secara parsial terdapat pengaruh yang signifikan antara Kepemimpinan tranformasional terhadap Kinerja guru SMA Sub Rayon 4 Pontianak, dengan Nilai sig. variabel Kepemimpinan tranformasional adalah 0,02 < 0,05. Kontribusi Budaya sekolah SMA Negeri Sub Rayon 04 Kota Pontianak terhadap Kinerja guru Dalam Melaksanakan Administrasi Pembelajaran Nilai sig. variabel Budaya sekolah adalah 0,00 < 0,05. Selanjutnya secara simultan terdapat pengaruh yang signifikan antara kepemimpinan transformasional kepala sekolah dan budaya sekolah terhadap kinerja guru SMA Sub Rayon 4 Pontianak, diketahui bahwa nilai F hitung adalah 151,726, sedang nilai F tabel adalah 2,740. Dengan demikian F hitung > F tabel, artinya H0 ditolak dan Ha diterima.Berdasarkan hasil penelitian,  maka disarankan  kepada Pimpinan SMA Negeri Sub Rayon 04 Kota Pontianak untuk lebih meningkatkan pelaksanaan kepemimpinan transformasional dan Budaya sekolah SMA Negeri Sub Rayon 04 Kota Pontianak secara optimal, dalam rangka menciptakan pembelajaran yang bermutu untuk meningkatkan mutu pendidikan. .  Kata Kunci : Kompensasi, Disiplin Kerja, Kepemimpinan dan Kinerja Karyawan
B-Cell Epitope Discovery: The First Protein Flexibility-Based Algorithm – Zika Virus Conserved Epitope Demonstration
Authors: Biner Daniel W. , Grosch Jason S. , Ortoleva Peter J.
Published: December 2020

Antibody-antigen interaction – at antigenic local environments called B-cell epitopes – is a prominent mechanism for neutralization of infection. Effective mimicry, and display, of B-cell epitopes is key to vaccine design. Here, a physical approach is evaluated for the discovery of epitopes which evolve slowly over closely related pathogens (conserved epitopes). The approach is 1) protein flexibility-based and 2) demonstrated with clinically relevant enveloped viruses, simulated via molecular dynamics. The approach is validated against 1) seven structurally characterized enveloped virus epitopes which evolved the least (out of thirty-eight enveloped virus-antibody structures) and 2) eight preexisting epitope and peptide discovery algorithms. Rationale for a new benchmarking scheme is presented. A data-driven epitope clustering algorithm is introduced. The prediction of eleven Zika virus epitopes (for future exploration on recombinant vaccine technologies) is demonstrated. For the first time, protein flexibility is shown to outperform solvent accessible surface area as an epitope discovery metric.
Efficient PCA-Exploration of High-Dimensional Datasets
Authors: Rodionova Oxana Ye. , Kucheryavskiy Sergey , Pomerantsev Alexey L.
Published: December 2020

Basic tools for exploration and interpretation of Principal Component Analysis (PCA) results are well- known and thoroughly described in many comprehensive tutorials. However, in the recent decade, several new tools have been developed. Some of them were originally created for solving authentication and classification tasks. In this paper we demonstrate that they can also be useful for the exploratory data analysis.

We discuss several important aspects of the PCA exploration of high dimensional datasets, such as estimation of a proper complexity of PCA model, dependence on the data structure, presence of outliers, etc. We introduce new tools for the assessment of the PCA model complexity such as the plots of the degrees of freedom developed for the orthogonal and score distances, as well as the Extreme and Distance plots, which present a new look at the features of the training and test (new) data. These tools are simple and fast in computation. In some cases, they are more efficient than the conventional PCA tools. A simulated example provides an intuitive illustration of their application. Three real-world examples originated from various fields are employed to demonstrate capabilities of the new tools and ways they can be used. The first example considers the reproducibility of a handheld spectrometer using a dataset that is presented for the first time. The other two datasets, which describe the authentication of olives in brine and classification of wines by their geographical origin, are already known and are often used for the illustrative purposes.

The paper does not touch upon the well-known things, such as the algorithms for the PCA decomposition, or interpretation of scores and loadings. Instead, we pay attention primarily to more advanced topics, such as exploration of data homogeneity, understanding and evaluation of an optimal model complexity. The examples are accompanied by links to free software that implements the tools.
Metallophilicity-Induced Clusterization: Single-Component White-Light Clusteroluminescence with Stimuli Responses
Authors: ZHAO Xueqian , Alam Parvej , Zhang Jianyu , Lin Shiyun , Peng Qian , Zhang Jun , Liang Guodong , Zhang Jing , Sung Herman H.-Y. , Lam Jacky W. Y. , williams ian duncan , Zhao Zheng , Gu Xinggui , Tang Ben Zhong
Published: December 2020

The single-component white-light-emitting materials play an essential role in the next-generation solid-state lighting technology. Herein, linear gold(I) complex TPPGPA with conglobate trimer configuration trigged by aurophilic interactions in crystalline state was prepared to emit dual phosphorescent white-light emission, which also exhibited multi-stimuli responsive luminescent properties including thermochromism and mechanochromism. Specifically, the molecular packing mode and aurophilic interactions regulation were subtly taken as a functional relationship of the experimental correlation with emission. The results showed that the regulated aurophilic interactions and restriction of molecular motion were determined to be the precipitating factor and as a function of the wavelength and intensity, which is significant for the design guide about intelligent stimuli-responsive white-light emissive luminescent materials. Furthermore, their application in temperature-responsive white-light illumination was successfully demonstrated.
Correlation between Yield and Reduced Mass of Raw Materials in Intermolecular and Intramolecular Cyclization Reactions
Authors: Kawashima Masatoshi
Published: December 2020

Correlation between yield and reduced mass of raw materials in intramolecular C-N, C-C, C-O coupling reactions and intramolecular/intermolecular Diels-Alder reactions was revealed. The regression equation was found to be the same as that of intermolecular reactions; yield = -0.1861MAB/(nAnBnI)+100.0, where MAB is the reduced mass per mole and nA and nB are the total number of each reaction site in molecular A and molecular B in the reaction system, and nI is the number to distinguish whether it is a intramolecular reaction or intermolecular reaction.
In-Vitro analysis of medicinal plant for anti-inflammatory properties
Authors: Naveen B  , Anil Kumar A  , Abhilash G  , Akila CR  , Raja Sheker K
Published: December 2020

This examination demonstrations the in vitro mitigating impact of leaf concentrates of Polyalthia longifolia. These were investigated in various measures to decide their mitigating impacts. Protein denaturation and RBC film adjustment were measured. The outcomes were accounted for as % hindrance in triplicate assurance and were exposed to factual additionally, diclofenac Aspirin and sodium were utilized as norms. The consequence of the % restraint of protein denaturation demonstrated that at 1mg/ml diclofenac, ethanolic extricate, new leaf fluid concentrate and dry leaf watery concentrate. Because of dissecting the MS and UV information and in contrast with the legitimate norms, an aggregate of 10 polyphenols were recognized and measured, counting gallic corrosive, catechin, quercetin, kaempferol, and their subordinates. This is the primary investigation looking at the leaves, as opposed to the organic product or seeds reasonably collected yet underutilized by nearby indigenous people groups. The concoction outline of the leaf was thoroughly broke down and prompted the ID of 10 polyphenol mixes, counting phenolic corrosive and flavonoids. The individual polyphenols were effectively quantitated, utilizing UV recognition. Additional bioactivity examinations demonstrated that the concentrates of leaf display cancer prevention agent, antiproliferation, and calming exercises. The primary atomic component may mostly be donated by the hindrance of NF-κB enactment, a typical sign alleyway among multiplication and aggravation. Additional examinations are expected to investigate whether these polyphenol mixes could work synergistically to accomplish significantly better exercises than each solitary segment. The concoction bioactivities and profile decided to help its conventional usage and might assistance for its additional pharmacological investigations and nutraceutical requests.
Screening and evaluation of Terminalia catappa and its compound application
Authors: Sravani G  , Linga Naik A  , Kranthi A  , Priyanka G
Published: December 2020

Plant determined medications remains an important source, particularly in creating countries, to look at genuine sicknesses roughly 62-80% of the total populace although everything depends on conventional medication for the therapy of specific disease. Indeed, plants produce a various scope of bioactive atoms creation them an ironic wellspring of an alternate kind of drugs. There are hardly any reports and utilization of plants in conventional mending by either ancestral individuals or indigenous network. Rejuvenating plants are the wellspring of extraordinary monetary estimation of everywhere on over the world. Nature has the best word on us a rich plant riches, and an enormous number of assorted kinds of plants develop in various pieces of the nation. Homegrown medication is as yet a pillar of around 75 to 85% the entire populace and the significant aspect of the conventional therapy the utilization of the plant extricate and the dynamic constituents. Among the 7000 types of rejuvenating plants perceived everywhere on over the world in excess of 9000, valuable medicinal plants are found in India. Unfortunately, just not many of them are utilized for their therapeutic worth. Around 1500 plants systematically utilize the conventional arrangement of Indian medication. Notwithstanding, the ethanopharmacologist, microbiologist, botanist and common item physicist world over today, is continually still looking for therapeutic adequacy of the plants on the phytochemicals. Along these lines, the quest for the new phytochemical is the foremost significant important to research the primer phytochemical examination to Terminalia catappa and Syzygium jumbolanam.
MỞ RỘNG TỪ ĐIỂN VIETSENTIWORDNET CHO MIỀN DỮ LIỆU THUỘC LĨNH VỰC DU LỊCH SỬ DỤNG PHƯƠNG PHÁP DỰA TRÊN TỪ VỰNG
Authors: Hòa Lê Văn
Published: December 2020

Khai phá quan điểm giúp xác định hướng quan điểm (tích cực, tiêu cực) của người dùng về một chủ đề, sản phẩm hay dịch vụ. Có một số cách tiếp cận khác nhau về khai phá quan điểm, trong đó phương pháp khai phá quan điểm dựa trên từ vựng là khá phổ biến. Độ chính xác của phương pháp khai phá quan điểm dựa trên từ vựng phụ thuộc rất nhiều vào từ điển được sử dụng, trong đó chứa các từ quan điểm về các lĩnh vực cụ thể. Một bộ dữ liệu có thể thực hiện phân lớp tốt trong lĩnh vực này, nhưng lại kém hiệu quả đối với một số lĩnh vực khác. VietSentiWordNet là từ điển quan điểm tiếng Việt được sử dụng khá phổ biến hiện nay, nhưng thiếu nhiều từ quan điểm cho miền dữ liệu thuộc lĩnh vực du lịch. Bài báo này do đó tập trung vào việc mở rộng từ điển VietSentiWordNet với việc làm giàu các từ quan điểm thuộc lĩnh vực du lịch, trong đó một mô hình mở rộng từ điển VietSentiWordNet dựa vào phương pháp dựa trên từ vựng được đề xuất và một tiến trình tiền xử lý dữ liệu với nhiều chức năng được tích hợp cũng được bổ sung nhằm nâng cao hiệu quả phân lớp quan điểm. Kết quả thực nghiệm cho thấy rằng việc từ điển VietSentiWordNet được mở rộng đã phân lớp quan điểm chính xác hơn đối với các câu quan điểm trong lĩnh vực du lịch.
RETRATO DOS CURSOS PRESENCIAIS DE LICENCIATURA EM MATEMÁTICA DA REGIÃO NORTE DO BRASIL
Authors: Uliana Marcia Rosa , Ribeiro Emerson da Silva
Published: December 2020

O estudo em tela teve como objetivo elaborar um panorama dos cursos de Licenciatura em Matemática, na modalidade presencial, ofertados na região Norte do Brasil. Consiste em uma pesquisa documental, desenvolvida com base na abordagem de investigação qualitativa e que se pautou nos Microdados do Censo da Educação Superior 2018. Com a investigação, constatou-se que havia, em 2018, na região Norte: 58 cursos de Licenciatura em Matemática, na modalidade presencial (20 no Pará, 19 no Amazonas, 5 em ambos os estados de Rondônia e Tocantins e 03 em cada um dos estados do Acre, Amapá e Roraima), localizados em todas as capitais e em algumas cidades do interior desses estados; ofertados por 19 instituições públicas, responsáveis por 53 cursos, e por 5 instituições privadas, com 5 cursos; alguns antigos, datando de 1954, outros recentes, como um criado em 2017. Também foi observado que esses cursos atenderam à demanda da região Norte quanto às vagas ofertadas e ocupadas e que seus alunos concluintes representaram 10% do total de concluintes no Brasil. Além disso, verificou-se que esses cursos ainda não conseguiram, em sua totalidade, reformular seus Projetos Pedagógicos em adequação às leis vigentes sobre formação inicial de professores, especificamente quanto à carga horária mínima e à oferta obrigatória do componente curricular de Libras.
KONFIGURASI SPASIAL RUMAH TRADISIONAL TEPAL DALAM KAITANNYA DENGAN ASPEK SOSIO BUDAYA (OBJEK STUDI: DESA TEPAL, KECAMATAN BATULANTEH, KABUPATEN SUMBAWA, NUSA TENGGARA BARAT)
Authors: Safa ; Yohanes Basuki Dwisusanto Ametha
Published: December 2020

Abstrak- Rumah adalah sebuah konsekuensi fenomena budaya, dimana bentuk dan organisasinya sangat dipengaruhi oleh lingkungan budaya tempatnya berada. Sosio-budaya sendiri merupakan hasil pikiran dan akal budi, yang ada untuk kehidupan bermasyarakat. Hasil dari proses berbudaya ini menghasilkan berbagai perwujudan, seperti kesenian, kepercayaan, hingga karya arsitektur.Desa Tepal di Sumbawa, Nusa Tenggara Barat, merupakan satu dari sedikit desa terpencil di Pulau Sumbawa yang masih mempertahankan tradisi dan adat istiadat yang diturunkan oleh para leluhurnya. Wujud fisik arsitekturalnya masih melekat dengan nilai-nilai dan tradisi yang berlaku. Hal ini dapat dilihat pada wujud fisik, sistem pengukuran, serta elemen lain pada rumah huniannya.Rumusan masalah yang menjadi landasan penelitian ini mencakup bagaimana aspek sosio budaya mempengaruhi konfigurasi spasial dan elemen pembentuk ruang Tepal. Tujuannya untuk menjelaskan kekuatan-kekuatan dalam kaitan aspek sosiobudaya yang mempengaruhi konfigurasi spasial dan elemen pembentuk ruang pada hunian.Metode yang digunakan pada penelitian ini merupakan metode kualitatif deskriptif dengan melakukan pengamatan terhadap wujud fisik hunian yang dipengaruhi oleh aspek sosiobudaya dari adat istiadat yang berlaku. Diperoleh kesimpulan bahwa terdapat aspek filosofis serta nilai-nilai seperti nilai kepercayaan, peran gender, usia, kebiasaan, dan ekonomi mempengaruhi penataan ruang pada bagian dalam, luar, serta elemen pembentuk rumah.
KLASIFIKASI ADAPTASI RUANG, DAN BENTUK PADA RUMAH MASYARAKAT DESA NGLEPEN
Authors: Sutoko ; Franseno Pujianto Winega
Published: December 2020

Abstrak- Pada tahun 2007 masyarakat Desa Nglepen Yogyakarta di relokasi ke kawasan permukiman bantuan yang dibangun oleh lembaga Dome For The World Foundation. Relokasi ini dilakukan karena rumah masyarakat Desa Nglepen hancur setelah insiden gempa pada tahun 2006. Kondisi hunian bantuan yang memiliki karakteristik fisik sangat berbeda dengan rumah pada umumnya memicu masyarakat Desa Nglepen untuk melakukan adaptasi. Penelitian ini membahas mengenai klasifikasi berdasarkan latar belakang pemicu adaptasi terhadap klasifikasi adaptasi berdasarkan ruang, dan bentuk masyarakat Desa Nglepen. Penelitian ini dilakukan untuk mengetahui bagaimana karakteristik hasil produk adaptasi yang dihasilkan berdasarkan latar belakang pendorong adaptasi dalam upaya mengakomodasi aktivitas sehari-hari.Penelitian menggunakan metode deskriptif dengan pendekatan kualitatif dengan cara mendeskripsikan kondisi eksisting rumah dome beserta dengan latar belakang perubahannya. Sampel penelitian pada klasifikasi adaptasi ini ditentukan pada masyarakat Desa Nglepen yang ingin menetap dengan huniannya. Pengumpulan data dilakukan melalui proses observasi dan wawancara terhadap penghuni rumah dome dan studi literatur. Analisis dilakukan berdasarkan teori strategi adaptasi dan faktor yang mempengaruhi perilaku adaptasi untuk mencari klasifikasi adaptasi berdasarkan latar belakang faktor yang mempengaruhi.Hasil dari klasifikasi berdasarkan latar belakang dan klasifikasi berdasarkan ruang, dan bentuk adalah karakteristik dari setiap adaptasi berdasarkan latar belakang pemicu adaptasi. Karakteristik adaptasi meliputi sifat ruang antara tertutup atau terbuka, kemudian penambahan massa yang mempengaruhi bentuk meliputi penambahan kearah depan, belakang, dan terpisah, pada rumah dome.
Kualitatif: Ciri dan Karakter Sebagai Metodologi
Authors: Kaharuddin Kaharuddin
Published: December 2020

Terlebih dahulu yang harus dipahami adalah karakter, ciri dan makna serta tujuan dari kualitatif itu sendiri. Pentingnya memahami karakter, ciri dan makna serta tujuan metode kualitatif agar peneliti tidak keliru dalam pengunaan metode tersebut, juga dapat mengetahu tujuan dari suatu penelitian yang mengunakan kualitatif. Jadi penggunaan kualitatif tidak hanya menjadi alat tempelan dalam metodologi disetiap jenis penelitian dalam menyusun skripsi ataupun tesis dan desertasi.
Effect of Endometrial Scratch on Heparin Binding Epidermal Growth Factor Level in Women Undergoing Intrauterine Insemination
Authors: D. Blawa Ekhlas , T.AL-Obaidi Manal ,   High Institute of Infertility Diagnosis and Assisted Reproductive Technologies, Al-Nahrain University, Baghdad, Iraq, A. Abdulhameed Wasan ,   High Institute of Infertility Diagnosis and Assisted Reproductive Technologies, Al-Nahrain University, Baghdad, Iraq
Published: December 2020

Despite many improvements in Assisted reproductive techniques during the last three decades, clinical pregnancy and live-birth rates still nearly 30–40% and 20–30%, respectively. To enhance endometrial receptivity many attempts done one of the endometrial scratching could provoke delay in endometrial maturation reforms asynchrony between endometrium and the concepts and indeed induce wound healing by producing a considerable raise in the local secretion of pro-inflammatory cytokines and growth factors like Heparin Binding Epidermal Growth Factor (HBEGF) and its receptors has role in mediate the receptivity, maturation, and decidualization of endometrium and facilitates the implantation and development of both placenta and embryo. All women were undergone IUI procedure. They divided into two groups. Intervention group who did endometrial scratching by using pipelle catheter in luteal phase of preceding cycle and another blood sample aspirated before scratch. Control group include women without intervention of endometrial scratch. Both groups underwent controlled ovarian stimulation, triggering of ovulation and another blood sample was aspirated at day of IUI to measure level of HBEGF. 14 days later with luteal support, BHCG test underwent in blood to check pregnancy. Higher pregnancy rate among patients with scratch group (5/20) 25% than non-interventional group (3/25)12%. These result showed that HBEGF level in scratch group (386.1±124.7) is significantly higher than control group (279±189.3) as P-value was (0.035). Moreover, the HBEGF level at day of IUI (455.67±157.34) and in pregnant (563.9±163.66) is significantly higher than before scratch in scratch group (279.0±124.67), (406.26±138.89), as P-values were (0.00007, 0.049) respectively. Intentional local damage to the endometrium is a cost–effective procedure can be used to enhance the uterine receptivity that may help to overcome implantation failure problem.
THE HAIRY MAIDEN: RUNAWAY AND DEITY
Authors:   Institute of Oriental Studies (RAS), Moscow, Russia, Starostina Aglaia B.
Published: December 2020

In this paper, the author offers a perspective on the evolution of the Hairy Maiden (Mao-nü) legends in written and oral Chinese tradition, from the twelfth century to the present day, on material of poems, short stories and records of the collectors of the Song – Qing eras, as well as memories of Hebei from the 1920s – 1940s and modern collections of fairy tales and legends. Attention is also paid to the pre-Song history of the character. The author suggested that it could be considered a borrowing. Field research data from 2014–2016 were used in the research. Mao-nü lives in wooded mountains, she is benevolent towards people. Stories about her can be divided into two distinctive groups. In the first group, she is a supernatural being for whom there is no return to human existence. In the second group, she returns to human existence, leaves the liminal zone and is doomed to die. W. Eberhard and Li Jianguo constructed the schemes close to the invariant of the Mao-nü plot. However, there are a few stories that do not correspond to those schemes as a whole, or their parts, in which the Hairy Maiden acts as a magical assistant. The paper describes the concept of Mao-nü as a deity and traces the connection of the Mao-nü stories to the Daoist hagiography (from “Lie xian zhuan” and on). The author also provides data on the perception of Mao-nü in the visual arts. The paper elaborates on the evidences that prove the direct descendance of the plot of the revolutionary opera “The White-Haired Girl” from ancient folklore. It describes further how the “revolutionary play” influenced the circulation of stories concerning the White-Haired fairy. An attempt is made to determine the ways in which the stories about the Hairy Maiden are connected to the stories about the “wild hairy people”, including the builders of the Great Wall. The author notes that for contemporary stories about Mao-nü, the proximity to written sources and links to the Huashan mountains are characteristic.
Cost-effective ultrasonic inspection of large diameter pipelines
Authors:   Intero Integrity Services, Augustijn Ries , Gonçalves João ,   Intero Integrity Services, Haaksman Joost ,   Intero Integrity Services
Published: December 2020

To be successful in the ILI business, organization require the right mix of technological capabilities, operational agility and quality standards. The business is fairly competitive, and often technological capabilities are pivotal in the customer proposition of the company. However, the best technologies are not solely required for successful ILI companies. Robustness of the system, operability by the ILI inspector, fitness of the product with commercial route to the market all contribute to a rapid return on investment. Providing a robust, versatile, high-resolution and cost-effective method to inspect large diameter pipelines was recognized as a challenge and opportunity. For that, a Large Diameter Ultrasonic Inspection tool capable of inspecting pipelines of 20 inch to 64 inch with high resolution was developed. The tool is always bi-directional and capable of mitigating 1.5D bends. Gathered data can be reviewed real-time during the inspection. The operating envelope of the tool is such that it can cope with various products in the pipeline, varying from (high salinity) water, crude oil and a multitude of refined products. Despite the fact that product properties (e.g. speed of sound, attenuation, temperature, etc) vary, the tool is designed such that this is not a limiting factor for the operating envelope. The application of advanced ultrasonic beam forming methodologies and signal generation and -processing ensure that the system is versatile and robust for these types of real-life operating conditions. This presentation will provide an overview of the utilization of these technologies, the validation program that has been used to demonstrate tool specifications and the experiences gained at successful projects.
Numerical method for identifying the flow model in the line pipe
Authors:   Pipeline Transport Institute, LLC, Zholobov Vladimir V.
Published: December 2020

With high availability of measuring tools and wide opportunities of modern computer technology, the existing methods of predictive estimations of hydraulic parameters for the fluids’ pipeline transport seem to be too approximate. Due to this, it is relevant to adapt the most accurate relationships available in the scientific and technical literature to real conditions. Based on the review of analytical solutions for calculating friction losses in the pressure lines, the structure of relationships most accurately reflecting the experimental data of I. Nikuradze is determined, where the hydraulic drag coefficient ? is described by the piecewise-continuous relations, given by O. M. Ayvazyan. The hydraulic drag coefficient structural relationship shall be selected with the highest capability to summarize the experimental data available in the scientific and technical literature. Using the pressure measurement data, free parameters included in the selected relationship for the hydraulic drag coefficient shall be identified. The numerical computation algorithm is proposed that enables to recover the values of parameters in the structural relationship of hydraulic drag coefficient ? through multiple application of the well-known method of sensitivity functions and pressure measurement data in the line pipe. The procedure is described for generating the computing system of ordinary differential equations that enables for every fixed set of experimental data (pressure and flow rate) to determine (or correct, if necessary) the corresponding parameters in the unified structural relationship for hydraulic drag coefficient ?. The feature of the proposed algorithm is the absence of embedded cycles. Dynamic control of variable parameters in the hydraulic drag coefficient ? based upon the proposed approach enables to improve the predictive estimations accuracy of flow parameters while pumping fluids and to acquire additional data on the state of the fluids filling the inner pipeline space.
Optimization modeling of degradation processes in crude oil spilled on the sea surface considering the wind conditions
Authors:   National aerospace Agency of Azerbaijan, Asadov Hikmat G. , Mammadli R. S. ,   National aerospace Agency of Azerbaijan
Published: December 2020

The article describes an optimization model study of degradation processes in crude oil spilled on the sea surface considering the wind conditions. A new configuration of a simplified optimization model of the oil degradation process on the sea surface is proposed. Based on the proposed configuration, a simplified optimization model of oil degradation on the sea surface has been developed. The optimal relationship between the time dependence of the wind speed and the fractional volume of oil volatilization is established, at which the minimum fractional volume of oil dissolved in water is attained.
Mustafa Kutlu’nun Bu Böyledir Adlı Eserinde Yapı ve Anlatım
Authors: YİĞİTLER Şener Şükrü
Published: December 2020

Mustafa Kutlu 1980’li yıllardan bu yana Türk öykücülüğünde kendine özgü bir dil ve üslup geliştiren önemli bir öykücüdür. Kutlu diğer eserleri arasında anlatım teknikleriyle öne çıkan Bu Böyledir adlı öykü kitabında, yaşanan toplumsal değişimi, bu değişimin bireyde açtığı çatışmayı sembolik bir dille işlerken geleneksel hikâye anlatma teknikleriyle modern edebiyat tekniklerini bir arada kullanır. Vermek istediği mesajları kitabın ana eksenini oluşturan ve bir bütün olarak dünyayı temsil eden lunapark imgesi etrafında aktaran Kutlu, öykülerde dinî/tasavvufi metinlerin hikâye anlatma geleneklerinin yanı sıra modern tekniklerden eşit biçimde faydalanır. Bu makalede, Bu Böyledir’de esere yapısını veren çerçeve öykücülüğü ile eserde kullanılan teknikler arasında en fazla öne çıkan laytmotif tekniğinin kullanımları ele alınmıştır.
The Effect of Subsidies on Healthful Consumption: Systematic Review and Data Synthesis
Authors: Abu-Hijleh Farah Marwan
Published: December 2020

Background: Prevalence of obesity and overweight has risen to the level of an epidemic. Health policy makers are seeking evidence-based solutions to this problem. This study reviews evidence on the subsidization of healthy foods as a fiscal tool to aid-in the public health response to this epidemic. Methods: A systematic search of the major databases was performed, and data extracted from studies meeting inclusion criteria. Main outcomes of interest were indicators of purchasing/consumption pattern, or body composition. Preliminary results are presented as a narrative summary. Results: Search results yielded 22 studies, of which 10 were extracted and 12 excluded. Of the 12 excluded 5 were duplicate studies of reports extracted, and 7 studies did not meet inclusion criteria. Most extracted studies were randomized control trials. The majority of the studies had multiple arms, one of which was typically a multi-component fiscal measure implemented alongside education or skills building. This type of multi-component intervention yielded the most promising results, mainly an increase in the percentage of daily fruit and/or vegetable consumption. This percentage increase varied between studies ranging from 4% up to 35%, with fruit consumption/purchasing responding more favorably to pricing changes compared to vegetable consumption/purchasing. Conclusion: Although preliminary, the results suggest that multi-component interventions appear to be the most promising in terms of real changes to purchasing behavior. Important considerations include the significant heterogeneity in reported outcomes, and the notable lack of studies assessing for substitution effects. Policy makers, in their examination of these findings, should consider these limitations.
The Impact of Pharmacist Interventions on Reducing Medication Errors in Pediatric Patients: A Systematic Review and Meta-analysis
Authors: Naseralallah Lina Mohammad , Hussain Tarteel Ali , Pawluk Shane , Eljaam Myriam
Published: December 2020

Background: Medication errors are avoidable events that could occur at any stage of the medication use process. They are widespread in the healthcare system and are associated with increased risk of morbidity and mortality. Implementing a clinical pharmacist is one strategy that is believed to reduce medication errors in the general population including pediatric patients who are more vulnerable to medication errors due to several contributing factors including the challenges of weight-based dosing. Aim: The aim of this study is to qualitatively and quantitatively evaluate the impact of clinical pharmacist interventions on medication error rates for hospitalized pediatric patients. Methodology: PubMed, Embase, Cochrane and Google Scholar search engines were searched from database inception to February 2019. Study selection, data extraction and quality assessment was conducted by two independent reviewers. Observational and interventional studies were included. Data extraction was done manually and the Crowe Critical Appraisal Tool (CCAT) was used to critically appraise eligible articles. Summary odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using a random-effects model for rates of medication errors. Results: A total of 19 studies were systematically reviewed and 6 studies (29 291 patients) were included in the meta-analysis. Pharmacist interventions involved delivering educational sessions, reviewing prescriptions, attending rounds and implementing a unit-based clinical pharmacist. The systematic review showed that the most common trigger for pharmacist interventions was inappropriate dosing. Pharmacist involvement was associated with significant reductions in the overall rate of medication errors occurrence (OR, 0.27; 95% CI, 0.15 to 0.49). Conclusion: The most common cause for pharmacist interventions in pediatric patients at hospital settings was inappropriate dosing. Overall, pharmacist interventions are effective at reducing medication error rates.
Patient Factors associated with Adherence and Change in Cardiac Risk Factors among Cardiac Rehabilitation Patients in Qatar
Authors: Saad Rahma , Al- Hashemi Mohammed , Papasavvas Theodoros , Turk-Adawi Karam
Published: December 2020

Background: Cardiovascular disease is the number one killer in Qatar (1). Cardiac rehabilitation (CR) is a secondary prevention model of care for cardiac patients. It is proven that CR reduces cardiovascular mortality by 20% (2). However, CR is underutilized worldwide, with low enrolment and adherence rates (3). This study aims (a) to investigate factors associated with adherence (median number of sessions, i.e. 21), and (b) to examine the relationship between adherence and change in cardiac risk factors, i.e. blood pressure, cholesterol, and low-density lipoprotein (LDL). Method: This retrospective cohort study included 714 cardiac patients, aged ≥18 years, who were referred to the cardiac rehabilitation program in Qatar. Data were collected from patients records from January 2013-September 2018. Logistic regression models were used to assess factors associated with adherence. Multiple linear regression models were used to examine the relationship between number of CR sessions attended and changes in cardiac risk factors. Results: The mean age of the study population was 52.7±10.1 years (mean ± SD). The majority of patients were males (n=641, 89.8%) and non-Qatari (n= 596, 83.5%),i.e. similar to Qatar population profile of 75% males and 15% Qatari, one fourth were smokers (n=185, 25.91%), and one fifth (n=128, 18.8%) had severe depression. Patients with AACVPR moderate- and high-risk levels were more likely to adhere compared to those with low risk. Percutaneous intervention and musculoskeletal disease were negatively associated with adherence. We found clinically significant improvements among adherents compared to non-adherents; reduction of 10% in cholesterol, and 15% in low density lipo-protein. Conclusion: This study provides new insights in Qatar, setting into factors that lead patients to adhere to their CR sessions. These factors represent opportunities for targeted interventions to improve CR utilization.
The role of Qatar Community Pharmacists in Depression care: A Survey of Attitudes, Practices and Perceived Barriers
Authors: Sham Rula , Alam Mohammed Fasihul , El Hajj Maguy
Published: December 2020

Background: Negative attitudes and stigma to mental health constitute major barriers to healthcare provision and access to treatment for patients with depression across the globe. Community pharmacists are among the most accessible healthcare providers who may play a significant role in depression care. This study aims to describe current practices, attitudes and perceived barriers of community pharmacists towards the provision of depression care, and investigates how pharmacists’ attitudes, along with several sociodemographic and professional characteristics, are associated with these practices. Methods: A crosssectional online survey targeting all practicing community pharmacists in Qatar using an adapted survey instrument. Responses were measured on a 5-point-Likert scale. Study outcomes were scores of attitudes towards depression, scores of self-reported depression care practices and perceived barriers for depression care. Descriptive univariate and bivariate analyses of study outcomes were conducted, along with a multivariate regression to investigate how pharmacists’ characteristics and attitudes affect their practice. Results: Three hundred fifty-eight pharmacists answered the survey, making a response rate of 39%. Pharmacists’ attitudes to depression were moderately positive (mean score=3.41, SD= 0.26). However, the extent of pharmacists’ involvement in depression care was very low (mean score=2.64, SD= 0.94). Three major barriers were the lack of access to patients' medical records (83.21%), lack of patients’ insight on major depression and the importance of treatment (81.85%) and the lack of needed knowledge and training on mental health (79.63%). Female pharmacists were significantly less involved in depression care compared to male pharmacists (p= 0.006). Depression practice score increased with an increasing score of attitudes (p =0.001) and decreased with the number of years since the last pharmacy degree graduation (p=0.02). The presence of a private area for counselling patients was associated with higher scores of practice (p=0.03). Conclusion: Pharmacists’ moderately positive attitudes towards depression and its care were not reflected in their current practices. Findings from the study imply the need for actions and training programs for pharmacists to improve their attitudes and practices towards depression care.
Prevalence of At-Risk Marriages among Couples attending Premarital Screening (PMS) Programs: A Systematic Review and Meta-Analysis
Authors: Syed BibiAsma , Alshafai Mashael , Turk-Adawi Karam
Published: December 2020

Background: Hemoglobinopathies are among the most common inherited genetic diseases. The World Health Organization estimates that at least 5% of the world’s population are carriers for hemoglobinopathies (2.9% for thalassemia and 2.3% for sickle cell disease). Programs like premarital screening (PMS) have been developed in most Middle East countries on a mandatory basis to reduce atrisk marriages by providing counseling after a confirmed “genetic carrier” state for hemoglobinopathies. Aim/Objective: The aim of this systematic review and meta-analysis was to estimate the prevalence of atrisk marriages globally and see the variation by region, income level, ethnicity, study period, implementation year of PMS program, study design and consanguinity proportion. Methods: Different databases such as PubMed, Science Direct, and Scopus were searched systematically by using key terms and MeSH Terms. Studies from Google Scholar and reference lists of studies were also collected, and the author extracted all relevant data. Two reviewers independently conducted quality assessment by using Hoy et al (2012) risk of bias tool. Quality effects model (QEM) was used due to considerable heterogeneity observed between studies. Subgroup analysis and sensitivity analysis were also performed for assessing the causes of heterogeneity. Results: A total of 15 studies were included in this meta-analysis. The overall pooled prevalence of at-risk marriages among total couples at-risk was 64% (95% CI: 49%- 78%). Estimates of several subgroups were found to be different as compared to the overall pooled estimate. Funnel plot and Doi plot indicated the presence of publication bias. Sensitivity analysis including only studies with low risk led to a pooled estimate of 52% (CI: 46%, 57%) and indicated absence of publication bias. Conclusion and recommendations: The pooled estimates varied widely and there was a substantial heterogeneity among studies, therefore, there is a need for more well-designed studies across different countries. Moreover, the importance of the quality of counseling sessions should be stressed and combined with efforts in other community sectors, such as high schools where students can attain high knowledge regarding genetic diseases before the age of marriage.
Design, Synthesis and Biological Evaluation of Novel Chalcone Analogs as Potential Therapeutic Agents for Castration-Resistant Prostate Cancer
Authors: Hussein Ola , Alali Feras , Al Moustafa Ala-Eddin , Khalil Ashraf
Published: December 2020

Prostate cancer (PCa) is the second most frequently diagnosed malignancy, as well as a leading cause of cancer-related mortality in men globally. Despite the initial response to hormonal targeted therapy, the majority of patients ultimately progress to a lethal form of the disease, termed as castration-resistant prostate cancer (CRPC), which currently lacks curative therapeutic options and is associated with poor prognosis. Therefore, the development of novel treatment modalities for PCa is urgently needed. Chalcones, also known as 1,3-diphenyl-2-propen-1-ones, are among the highly attractive scaffolds being investigated for their antitumor activities. Three series of 18 cyclic (tetralone-based) and two acyclic chalcone analogs, in which ring B was either substituted with nitrogen mustard or replaced by pyrrole or pyridine heterocyclic rings, were designed, synthesized and evaluated as potential therapies for CRPC. Compounds were synthesized by Claisen-Schmidt condensation reaction, purified using columnchromatography or recrystallization and characterized by 1H-NMR, 13C-NMR and LC-MS. The compounds' in-vitro cytotoxicity was evaluated against three prostate cancer cell lines (PC3, DU145, and LNCaP). Among the tested compounds, OH14, OH19 and OH22 showed potent antiproliferative activities at low micromolar levels with IC50 values ranging between 4.4 and 10 µM against PC3 and DU145 cell lines. Detailed biological studies of the lead molecule OH19 revealed that it significantly induces apoptosis through upregulation of Bax and downregulation of BCL-2. In addition, OH19 potently inhibits colony formation and reduces cell migration of androgen-independent PCa cell lines (PC3 and DU145). The molecular pathway analysis show that the anticancer activity of OH19 is associated with attenuation in the phosphorylation of Akt and ERK. Furthermore, OH19 inhibits blood vessel formation in the chick chorioallantoic membrane (CAM) model as compared to control. These results indicate that OH19 could serve as a potential promising lead molecule for the treatment of CRPC and thus, further in-vitro and invivo studies are warranted.
Improving Waiting Times in Hand Surgery Clinic at Rumailah Hospital, Qatar
Authors: Abd al Hadi Samah Ahmad , Abousaad Amal , Shraim Mujahed
Published: December 2020

Background: The quality and efficiency of healthcare delivery are key drivers that influence hospital quality as well as patient satisfaction. The patient waiting time is the period of time that passes between patients first seeking medical treatment from the healthcare system and their admittance for consultation and diagnosis. The hand surgery clinic at Rumailah Hospital (RH) in Qatar has seen that only 12% of new patients who had been referred for urgent treatment from the accident and emergency department had received an appointment within 14 days. Aim: To increase the percentage of patients with new, urgent referrals to the hand surgery clinic at Rumailah Hospital from the accident and emergency department to be seen within 14 days from the current 12% to 20% by the end of October 2019 and from 20% to 60% by the end of April 2020. Methodology: This is a Quality improvement Project used the Institute for Healthcare Improvement model for improvement, the team used the root cause analysis to identify the bottleneck in the process, the Plan- Do - Study - Act (PDSA) cycles facilitates testing the selected changes: increase capacity, triage acciedent and emergency referrals, and clear the back log. Results: After implementing the changes, we observed increase in the proportion of patients who received appointments within 14 days of the referral, from 22% in July to 26% in August and 40% in September and October, 2019. Conclusion: The project team did extensive research in understanding the complex process of OPD appointment and clinic consultation. The project team tested three change ideas that yielded to manage the percentage of patients who received appointments within 14 days. The team is planning to test the next change idea to improve the triaging process by implementing electronic triaging, which is expected to reduce the waiting time for an appointment in the clinic.
Experiences of Weight-based Oppression in Qatar
Authors: O'Hara Lily , Alajaimi Bayan , Alshowaikh Bayan
Published: December 2020

Introduction: Weight-based oppression is a widespread phenomenon in Western countries. External sources of weight-based oppression include exposure to stigmatizing or exclusionary social, cultural, economic, political and built environments, weight bias and discrimination, and weight-based bullying and violence. Internal sources of weight-based oppression are the internalized negative attitudes, values and beliefs people hold about body weight. Weight-based oppression is associated with a range of psychological, physiological and behavioral harms such as depression, anxiety, disordered eating, hypertension, allostatic load, cortisol reactivity and oxidative stress. Research on weight-based oppression is largely absent from the Arab region. The objectives of the study were to examine the internalized attitudes, values and beliefs related to body weight, and experiences of external weight based oppression, including teasing, bullying, stigmatization, and discrimination among staff, faculty and students at Qatar University. Methods: We conducted in-depth semi-structured interviews with 29 participants (25 females) aged 18 to 53 years who were recruited using convenience and snowball sampling. Thematic analysis was used to identify major themes. Results: Internal and external weight-based oppression were experienced by all participants and regarded as so common in Arabic culture as to be normative. There were five major themes that related to the various types of weight based oppression experiences, internalized feelings about weight based oppression, and the timing, source and impact of weight based oppression. Conclusion: Weight-based oppression in the Arab region is an important and unrecognized public health issue. Programs should be developed to reduce exposure to weightbased oppression in all sectors. Reducing teasing, bullying and negative experiences related to body weight in childhood should be a public health priority.