bluuebunny/crossref_metadata_2025 huggingface dataset:
Data-Driven Insights on the Effects of COVID-19 on Public Interest in Medical Aesthetics: Part II (Active Analysis)
Authors: Jenny Hillary E , Chandawarkar Akash , Kim Roy
Published: October 2020

Background

The COVID-19 pandemic significantly affected financial and psychosocial factors that influence plastic surgery demand.

Objectives

The authors sought to actively assess public interest changes and the reasons underlying these shifts.

Methods

Using Amazons’ Mechanical Turk, we crowdsourced public opinions regarding aesthetic interventions from April 30 to May 3, 2020. The survey assessed prior experience with and interest in 6 aesthetic interventions before and during the pandemic and reasons for changing interest. United States residents aged 18 years and over who passed the attention check were included.

Results

We included 704 of 838 total responses. One-half of respondents were female; the median age group was 25 to 34 years. During the pandemic, 21% of respondents had increased and 33% decreased interest in at least one intervention. Non-invasive procedures (7.3%), facial aesthetic surgery (6.6%), and medical-grade skincare (5.9%) elicited the greatest interest increase. Seeing themselves in the mirror more often (43.2%), desire to look better after the crisis (41.8%), and increased time on social media (40.4%) were the top reasons for increased interest. The most common reasons for decreased interest were changing spending priorities (58%), focusing on other health aspects (49.8%), and worrying about infection in medical facilities (46.3%). Almost one-half of respondents considered virtual consultations for interventions of increased interest.

Conclusions

The COVID-19 pandemic significantly affected interest in medical aesthetics. Offering telemedicine and discussing detailed COVID-19 infection control policies with patients will be critical to address patient needs and concerns. These findings can be used to improve patient outreach, advertisement, and counseling as practices focus on reopening.
Agile workflow for interactive analysis of mass cytometry data
Authors: Casado Julia , Lehtonen Oskari , Rantanen Ville , Kaipio Katja , Pasquini Luca , Häkkinen Antti , Petrucci Elenora , Hynninen Johanna , Hietanen Sakari , Carpén Olli , Biffoni Mauro , Färkkilä Anniina , Hautaniemi Sampsa
Published: October 2020

Motivation

Single-cell proteomics technologies, such as mass cytometry, have enabled characterization of cell-to-cell variation and cell populations at a single-cell resolution. These large amounts of data, require dedicated, interactive tools for translating the data into knowledge.

Results

We present a comprehensive, interactive method called Cyto to streamline analysis of large-scale cytometry data. Cyto is a workflow-based open-source solution that automates the use of state-of-the-art single-cell analysis methods with interactive visualization. We show the utility of Cyto by applying it to mass cytometry data from peripheral blood and high-grade serous ovarian cancer (HGSOC) samples. Our results show that Cyto is able to reliably capture the immune cell sub-populations from peripheral blood and cellular compositions of unique immune- and cancer cell subpopulations in HGSOC tumor and ascites samples.

Availabilityand implementation

The method is available as a Docker container at https://hub.docker.com/r/anduril/cyto and the user guide and source code are available at https://bitbucket.org/anduril-dev/cyto.

Supplementary information

Supplementary data are available at Bioinformatics online.
The value of recognition theory to Family Group Conferencing and child-care and protection
Authors: Mitchell Mary
Published: October 2020

Much has been written over the past thirty years within the international social work literature on Family Group Conferencing as a process of decision making. Yet, the theories that frame our understanding of how Family Group Conferencing contributes towards family outcomes are less distinct. This article makes an original contribution to this literature by proposing the use of recognition theory as a beneficial lens for understanding the Family Group Conferencing process. The recognition theory contends that social relations acknowledge and validate personal existence and are pivotal to identify formation; a just society is therefore one where everyone gets due recognition. A retrospective qualitative study will be used to exemplify how Family Group Conferencing can create the conditions within which participants can experience different forms of recognition: care; respect; solidarity and, as such, experience a level of social justice (or not). It is argued that recognition within the Family Group Conferencing process can influence the identity and relationships of those involved in social work services. This article has significance beyond those with an interest in Family Group Conferencing as the recognition theory can shed light on the nature of relationships in social work practice more generally.
Separation of Fatty Acid Dimethyl Esters on an Ionic Liquid Gas Chromatographic Column
Authors: Pauls R E , Pease B
Published: October 2020

An ionic liquid (IL) 111 column was compared with other commonly employed stationary phases including polydimethyl siloxane and polyethylene glycol for the separation of fatty acid monomethyl and dimethyl esters. The fatty acid esters employed in this study were derived from metathesis reactions of vegetable oils both with and without olefins. The IL 111 column demonstrated enhanced performance compared with conventional columns for the separation of these esters. These advantages included significantly enhanced retention of dimethyl esters relative to monomethyl esters, excellent cis/trans isomer separation and the ability to analyze higher carbon number dimethyl esters. As a result, these columns are highly suited for the analysis of mixtures of mono- and dimethyl fatty acid esters found in lipid metathesis reaction products or to determine monofunctional impurities in samples of commercial dimethyl esters.
Unraveling the Modes of Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) During a Nursing Home Outbreak: Looking Beyond the Church Superspreading Event
Authors: Voeten Helene A C M , Sikkema Reina S , Damen Marjolein , Oude Munnink Bas B , Arends Carla , Stobberingh Ellen , Hoogervorst Ellen , Koopmans Marion P G , Fanoy Ewout
Published: October 2020

Background

An outbreak of coronavirus disease 2019 (COVID-19) in a nursing home in the Netherlands, following an on-site church service held on 8 March 2020, triggered an investigation to unravel sources and chain(s) of transmission.

Methods

Epidemiological data were collected from registries and through a questionnaire among church attendees. Symptomatic residents and healthcare workers (HCWs) were tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by reverse-transcription polymerase chain reaction and subjected to whole genome sequencing (WGS). Sequences from a selection of people from the same area were included as community reference.

Results

After the church service, 30 of 39 attendees (77%) developed symptoms; 14 (11 residents and 3 nonresidents) were tested and were positive for COVID-19. In the following 5 weeks, 62 of 300 residents (21%) and 30 of 640 HCWs (5%) tested positive for COVID-19; 21 of 62 residents (34%) died. The outbreak was controlled through a cascade of measures. WGS of samples from residents and HCWs identified a diversity of sequence types, grouped into 8 clusters. Seven resident church attendees all were infected with distinct viruses, 4 of which belonged to 2 larger clusters in the nursing home.

Conclusions

Although initial investigation suggested the church service as the source of the outbreak, detailed analysis showed a more complex picture, most consistent with widespread regional circulation of the virus in the weeks before the outbreak, and multiple introductions into the nursing home before the visitor ban. The findings underscore the importance of careful outbreak investigations to understand SARS-CoV-2 transmission to develop evidence-based mitigation measures.
Response to the Coronavirus Disease 2019 Pandemic Among People Experiencing Homelessness in Congregant Living Settings in San Diego, California
Authors: Marquez Hanna , Ramers Christian , Northrup Adam , Tam Aaron , Liu Jie , Rojas Sarah , Klaman Stacey , Khasira Maureen , Madbak Jenan , Matthews Eva , Norris Jeffrey , Godino Job
Published: October 2020

During April 2020-August 2020, a preemptive testing strategy combined with accessible isolation and symptom screening among people experiencing homelessness in congregant living settings in San Diego, California, contributed to a low incidence proportion of coronavirus disease 2019 (0.9%). Proactively addressing challenges specific to a vulnerable population may prove impactful.
A randomized phase 1b cross-over study of the safety of low-dose pioglitazone for treatment of autosomal dominant polycystic kidney disease
Authors: Blazer-Yost Bonnie L , Bacallao Robert L , Erickson Bradley J , LaPradd Michelle L , Edwards Marie E , Sheth Nehal , Swinney Kim , Ponsler-Sipes Kristen M , Moorthi Ranjani N , Perkins Susan M , Torres Vicente E , Moe Sharon M
Published: October 2020

Background

Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common monogenetic disorders in humans and is characterized by numerous fluid-filled cysts that grow slowly, resulting in end-stage renal disease in the majority of patients. Preclinical studies have indicated that treatment with low-dose thiazolidinediones, such as pioglitazone, decrease cyst growth in rodent models of PKD.

Methods

This Phase 1b cross-over study compared the safety of treatment with a low dose (15 mg) of the peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist pioglitazone or placebo in PKD patients, with each treatment given for 1 year. The study monitored known side effects of PPAR-γ agonist treatment, including fluid retention and edema. Liver enzymes and risk of hypoglycemia were assessed throughout the study. As a secondary objective, the efficacy of low-dose pioglitazone was followed using a primary assessment of total kidney volume (TKV), blood pressure (BP) and kidney function.

Results

Eighteen patients were randomized and 15 completed both arms. Compared with placebo, allocation to pioglitazone resulted in a significant decrease in total body water as assessed by bioimpedance analysis {mean difference 0.16 Ω [95% confidence interval (CI) 0.24–2.96], P = 0.024} and no differences in episodes of heart failure, clinical edema or change in echocardiography. Allocation to pioglitazone led to no difference in the percent change in TKV of −3.5% (95% CI −8.4–1.4, P = 0.14), diastolic BP and microalbumin:creatinine ratio.

Conclusions

In this small pilot trial in people with ADPKD but without diabetes, pioglitazone 15 mg was found to be as safe as placebo. Larger and longer-term randomized trials powered to assess effects on TKV are needed.
The effect of injection and topical application of hCG and GnRH agonist to induce sperm-release in the roseate frog, Geocrinia rosea
Authors: Silla Aimee J , Roberts J Dale , Byrne Phillip G
Published: October 2020

Reproductive technologies may assist amphibian conservation breeding programs (CBPs) to achieve propagation targets and genetic management goals. However, a trial-and-error approach to protocol refinement has led to few amphibian CBPs routinely employing reproductive technologies with predictable outcomes. Additionally, while injections can be safely administered to amphibians, perceived animal welfare risks, such as injury and disease transmission, warrant the development of alternative hormone administration protocols. The present study investigated the spermiation response of roseate frogs, Geocrinia rosea, administered various doses of human chorionic gonadotropin (hCG) and gonadotropin-releasing hormone agonist (GnRH-a) via subcutaneous injection. This study also quantified the spermiation response of frogs administered both hormones via topical application. Total sperm, sperm concentration and sperm viability were assessed over a 12-h period post hormone administration. Males released sperm in response to the injection of hCG (88–100% response; 5, 10 or 20 IU), but all samples collected from males administered hCG topically (100, 100 + DMSO or 200 IU hCG) were aspermic. In contrast, males consistently released sperm in response to both the injection (100% response; 1, 5 or 10 μg), or topical application (80–100% response; 50, 50 + DMSO or 100 μg) of GnRH-a. Overall, the administration of GnRH-a was more effective at inducing spermiation than hCG. Mean total sperm and sperm concentration were highest in response to the optimal topically applied dose of 100 μg GnRH-a (mean total sperm = 2.44 × 103, sperm concentration = 1.48 × 105 sperm/ml). We provide novel evidence that topical application provides a viable alternative to injection for the administration of GnRH-a to induce spermiation in amphibians.
Gender-Based Pathways to Cognitive Aging in the Mexican-Origin Population in the United States: The Significance of Work and Family
Authors: Rote Sunshine M , Angel Jacqueline L
Published: October 2020

Objectives

This study uses the life course perspective to explore the role of key midlife factors (occupation and number of children) for gender- and nativity-based pathways to cognitive aging for older Mexican Americans.

Method

Using the Hispanic Established Populations for the Epidemiologic Study of the Elderly (H-EPESE, 1993/1994–2016, n = 2,779), this study presents (a) cognitive impairment trajectories over 20 years of data and (b) multinomial logistic regression analyses of trajectory group membership by lifetime occupation and number of children, controlling for educational attainment.

Results

For older Mexican American men, lifetime employment in agricultural occupations is associated with elevated risk for late-life cognitive impairment. Delayed risk for impairment is observed for U.S.-born men who were employed in factory work (e.g., production and repair) and in Mexican-born men who were employed in occupations with skilled or supervisory requirements. For all women, labor force participation, especially in skilled occupations, is related to a delayed risk of cognitive impairment. Number of children is unrelated to impairment for men; however, women with five or more children (compared to women with two to four children) are at risk for consistent and rapid cognitive impairment in late life.

Discussion

Late-life cognitive health disparities that disproportionately impact the Mexican American population can be addressed by improving access to educational and occupational opportunities in early and midlife. This study points to key areas of intervention within work and the home for the Mexican-origin population.
On the role of solute drag in reconciling laboratory and natural constraints on olivine grain growth kinetics
Authors: Furstoss Jean , Petit Carole , Tommasi Andrea , Ganino Clément , Muñoz Daniel Pino , Bernacki Marc
Published: October 2020

We investigate the effect of solute drag on the grain growth (GG) kinetics in olivine-rich rocks through full field and mean field modelling. Considering a drag force exerted by impurities on grain boundary migration allows reconciling laboratory and natural constraints on olivine GG kinetics. Solute drag is implemented in a full field level-set framework and in a mean field model that explicitly accounts for a grain size distribution. After calibration of the mean field model on full field results, both models are able to both reproduce laboratory GG kinetics and predict grain sizes consistent with observations in peridotite xenoliths from different geological contexts.
Comparing the use of direct observation, standardized patients and exit interviews in low- and middle-income countries: a systematic review of methods of assessing quality of primary care
Authors: Aujla Navneet , Chen Yen-Fu , Samarakoon Yasara , Wilson Anna , Grolmusová Natalia , Ayorinde Abimbola , Hofer Timothy P , Griffiths Frances , Brown Celia , Gill Paramjit , Mallen Christian , Sartori Jo , Lilford Richard J
Published: October 2020

Clinical records in primary healthcare settings in low- and middle-income countries (LMIC) are often lacking or of too poor quality to accurately assess what happens during the patient consultation. We examined the most common methods for assessing healthcare workers’ clinical behaviour: direct observation, standardized patients and patient/healthcare worker exit interview. The comparative feasibility, acceptability, reliability, validity and practicalities of using these methods in this setting are unclear. We systematically review and synthesize the evidence to compare and contrast the advantages and disadvantages of each method. We include studies in LMICs where methods have been directly compared and systematic and narrative reviews of each method. We searched several electronic databases and focused on real-life (not educational) primary healthcare encounters. The most recent update to the search for direct comparison studies was November 2019. We updated the search for systematic and narrative reviews on the standardized patient method in March 2020 and expanded it to all methods. Search strategies combined indexed terms and keywords. We searched reference lists of eligible articles and sourced additional references from relevant review articles. Titles and abstracts were independently screened by two reviewers and discrepancies resolved through discussion. Data were iteratively coded according to pre-defined categories and synthesized. We included 12 direct comparison studies and eight systematic and narrative reviews. We found that no method was clearly superior to the others—each has pros and cons and may assess different aspects of quality of care provision by healthcare workers. All methods require careful preparation, though the exact domain of quality assessed and ethics and selection and training of personnel are nuanced and the methods were subject to different biases. The differential strengths suggest that individual methods should be used strategically based on the research question or in combination for comprehensive global assessments of quality.
Direct-Acting Antiviral Hepatitis C Treatment Cascade and Barriers to Treatment Initiation Among US Men and Women With and Without HIV
Authors: Haley Danielle F , Edmonds Andrew , Ramirez Catalina , French Audrey L , Tien Phyllis , Thio Chloe L , Witt Mallory D , Seaberg Eric C , Plankey Michael W , Cohen Mardge H , Adimora Adaora A
Published: October 2020

Background

People with HIV are disproportionately coinfected with hepatitis C virus (HCV) and experience accelerated liver-related mortality. Direct-acting antivirals (DAAs) yield high sustained virologic response (SVR) rates, but uptake is suboptimal. This study characterizes the DAA-era HCV treatment cascade and barriers among US men and women with or at risk for HIV.

Methods

We constructed HCV treatment cascades using the Women’s Interagency HIV Study (women, 6 visits, 2015–2018, n = 2447) and Multicenter AIDS Cohort Study (men, 1 visit, 2015–2018, n = 2221). Cascades included treatment-eligible individuals (ie, HCV RNA-positive or reported DAAs). Surveys captured self-reported clinical (eg, CD4), patient (eg, missed visits), system (eg, appointment access), and financial/insurance barriers.

Results

Of 323/92 (women/men) treatment eligible, most had HIV (77%/70%); 69%/63% were black. HIV-positive women were more likely to attain cascade outcomes than HIV-negative women (39% vs 23% initiated, 21% vs 12% SVR); similar discrepancies were noted for men. Black men and substance users were treated less often. Women initiating treatment (vs not) reported fewer patient barriers (14%/33%). Among men not treated, clinical barriers were prevalent (53%).

Conclusions

HIV care may facilitate HCV treatment linkage and barrier navigation. HIV-negative individuals, black men, and substance users may need additional support.

Clinical trials registration

NCT00000797 (Women’s Interagency HIV Study); NCT00046280 (Multicenter AIDS Cohort Study).
Descriptive examination of secure messaging in a longitudinal cohort of diabetes patients in the ECLIPPSE study
Authors: Cemballi Anupama Gunshekar , Karter Andrew J , Schillinger Dean , Liu Jennifer Y , McNamara Danielle S , Brown William , Crossley Scott , Semere Wagahta , Reed Mary , Allen Jill , Lyles Courtney Rees
Published: October 2020

The substantial expansion of secure messaging (SM) via the patient portal in the last decade suggests that it is becoming a standard of care, but few have examined SM use longitudinally. We examined SM patterns among a diverse cohort of patients with diabetes (N = 19 921) and the providers they exchanged messages with within a large, integrated health system over 10 years (2006-2015), linking patient demographics to SM use. We found a 10-fold increase in messaging volume. There were dramatic increases overall and for patient subgroups, with a majority of patients (including patients with lower income or with self-reported limited health literacy) messaging by 2015. Although more physicians than nurses and other providers messaged throughout the study, the distribution of health professions using SM changed over time. Given this rapid increase in SM, deeper understanding of optimizing the value of patient and provider engagement, while managing workflow and training challenges, is crucial.
Allele-Specific Expression and Evolution of Gene Regulation Underlying Acute Heat Stress Response and Local Adaptation in the CopepodTigriopus californicus
Authors: Tangwancharoen Sumaetee , Semmens Brice X , Burton Ronald S
Published: October 2020

Geographic variation in environmental temperature can select for local adaptation among conspecific populations. Divergence in gene expression across the transcriptome is a key mechanism for evolution of local thermal adaptation in many systems, yet the genetic mechanisms underlying this regulatory evolution remain poorly understood. Here we examine gene expression in 2 locally adapted Tigriopus californicus populations (heat tolerant San Diego, SD, and less tolerant Santa Cruz, SC) and their F1 hybrids during acute heat stress response. Allele-specific expression (ASE) in F1 hybrids was used to determine cis-regulatory divergence. We found that the number of genes showing significant allelic imbalance increased under heat stress compared to unstressed controls. This suggests that there is significant population divergence in cis-regulatory elements underlying heat stress response. Specifically, the number of genes showing an excess of transcripts from the more thermal tolerant (SD) population increased with heat stress while that number of genes with an SC excess was similar in both treatments. Inheritance patterns of gene expression also revealed that genes displaying SD-dominant expression phenotypes increase in number in response to heat stress; that is, across loci, gene expression in F1’s following heat stress showed more similarity to SD than SC, a pattern that was absent in the control treatment. The observed patterns of ASE and inheritance of gene expression provide insight into the complex processes underlying local adaptation and thermal stress response.
Efficacy and safety of abiraterone acetate plus prednisolone in patients with early metastatic castration-resistant prostate cancer who failed first-line androgen-deprivation therapy: a single-arm, phase 4 study
Authors: Kobayashi K , Okuno N , Arai G , Nakatsu H , Maniwa A , Kamiya N , Satoh T , Kikukawa H , Nasu Y , Uemura H , Nakashima T , Mikami K , Iinuma M , Tanabe K , Furukawa J , Kobayashi H
Published: October 2020

Aim

The aim was to evaluate the efficacy and safety of abiraterone acetate plus prednisolone in patients with chemotherapy-naïve early metastatic castration-resistant prostate cancer who failed first-line androgen deprivation therapy.

Methods

Patients with early metastatic castration-resistant prostate cancer with confirmed prostate-specific antigen progression within 1-year or prostate-specific antigen progression without having normal prostate-specific antigen level (<4.0 ng/mL) during first-line androgen deprivation therapy were enrolled and administered abiraterone acetate (1000 mg) plus prednisolone (10 mg). A minimum of 48 patients were required according to Simon’s minimax design. The primary endpoint was prostate-specific antigen response rate (≥50% prostate-specific antigen decline by 12 weeks), secondary endpoints included prostate-specific antigen progression-free survival and overall survival. Safety parameters were also assessed.

Results

For efficacy, 49/50 patients were evaluable. Median age was 73 (range: 55–86) years. The median duration of initial androgen deprivation therapy was 32.4 (range: 13.4–84.1) weeks and 48 patients experienced prostate-specific antigen progression within 1-year after initiation of androgen deprivation therapy. prostate-specific antigen response rate was 55.1% (95% confidence interval: 40.2%–69.3%), median prostate-specific antigen–progression-free survival was 24.1 weeks, and median overall survival was 102.9 weeks (95% confidence interval: 64.86 not estimable [NE]). Most common adverse event was nasopharyngitis (15/50 patients, 30.0%). The most common ≥grade 3 adverse event was alanine aminotransferase increased (6/50 patients, 12.0%).

Conclusions

Abiraterone acetate plus prednisolone demonstrated a high prostate-specific antigen response rate of 55.1%, suggesting tumor growth still depends on androgen synthesis in patients with early metastatic castration-resistant prostate cancer. However, prostate-specific antigen–progression-free survival was shorter than that reported in previous studies. Considering the benefit–risk profile, abiraterone acetate plus prednisolone would be a beneficial treatment option for patients with chemotherapy-naive metastatic prostate cancer who show early castration resistance.
Aedes albopictus (Diptera: Culicidae) Monitoring in the Lazio Region (Central Italy)
Authors: Romiti Federico , Ermenegildi Arianna , Magliano Adele , Rombolà Pasquale , Varrenti Donatella , Giammattei Roberto , Gasbarra Silvia , Ursino Simona , Casagni Luca , Scriboni Andrea , Puro Vincenzo , Ruta Amilcare , Brignola Laura , Fantasia Oriano , Corpolongo Daniela , Di Luzio Giuseppe , De Liberato Claudio
Published: October 2020

The Asian tiger mosquito Aedes albopictus (Skuse 1894) is assuming an ever-increasing importance as invasive species in Europe and consequently as human health and nuisance concern. In Central Italy, the species has been recently involved in a chikungunya outbreak. A 3 yr Ae. albopictus monitoring was carried out in 21 municipalities of the Lazio region (Central Italy), belonging to three provinces. Samplings were performed on a weekly basis using ovitraps, in order to investigate climatic and spatial variables driving egg abundance and Ae. albopictus period of activity. A temperature of 10.4°C was indicated as lower threshold for the onset of egg-laying activity, together with a photoperiod of 13:11 (L:D) h. The whole oviposition activity lasted 8 mo (May–December), with 95% of eggs laid between early June and mid-November and a peak at the end of August. Egg abundance was positively influenced by accumulated temperature (AT) of the 4 wk preceding sampling and negatively by precipitation during the week before. Egg-laying activity dropped with decreasing AT, increasing rainfall, and with a photoperiod below 10:14 (L:D) h. Our results pinpointed the importance of fine-scaled spatial features on egg abundance. Some of these fine-scaled characteristics have been highlighted, such as the presence of vegetation and human footprint index. Our model estimated an almost doubled maximum number of laid eggs for the maximum value of human footprint. Compelling evidence of the relevance of fine-scaled characteristics was reported, describing cases where human-made breeding sites driven the abundance of Ae. albopictus.
‘I Try Not to Be Dominant, but I’m a Lawyer!’: Advisor Resources, Context, and Refugee Credibility
Authors: Smith-Khan Laura
Published: October 2020

Credibility assessments are a key component of refugee status determination. However, the difficulties associated with these assessments make professional assistance important. This article examines qualitative interviews with eight Australian migration advisors, exploring the key resources they report drawing on when contributing to client credibility in refugee status determination processes. Participants make sense of these resources and their choices about how they mobilize them by explicitly situating them within institutional and policy contexts. The article concludes that individual advisors vary in their approaches based on their beliefs about the particular resources they can and should mobilize within this context. These beliefs and practices, and the resources and contexts underlying them, have implications for how advisors contribute to asylum-seeker credibility, and ultimately, for access to refugee protection.
Prosocial Development in Refugee Children
Authors: Malti Tina , Galarneau Emma , Zhang Linlin , Myatt Eleanor , Yavuz H Melis
Published: October 2020

Understanding how to best support resettled refugee children’s social adjustment is paramount, yet such research is scarce. In this study, we examined the prosocial functioning of refugee children who had recently resettled in Canada (N = 93; 5- to 12-year-olds; Mage = 8.16; 55% girls). Children described instances when they helped and received help from someone, and the motivations behind each helping behaviour. In narratives about providing help, children most frequently reported direct help. In narratives about receiving help, children most frequently described being taught something. Consistent with previous work with Western and non-refugee children, the children most frequently reported sympathy-based motives. However, they also frequently cited relationship-based motives—a finding which may be unique to refugee experiences (e.g. separation from family). We found developmental differences in the types of prosocial behaviours and motivations. Implications for future culturally sensitive assessments of refugee children’s positive social adjustment and mental health outcomes are discussed.
Coordinated decline of leaf hydraulic and stomatal conductances under drought is not linked to leaf xylem embolism for different grapevine cultivars
Authors: Albuquerque Caetano , Scoffoni Christine , Brodersen Craig R , Buckley Thomas N , Sack Lawren , McElrone Andrew J
Published: October 2020

Drought decreases water transport capacity of leaves and limits gas exchange, which involves reduced leaf leaf hydraulic conductance (Kleaf) in both the xylem and outside-xylem pathways. Some literature suggests that grapevines are hyper-susceptible to drought-induced xylem embolism. We combined Kleaf and gas exchange measurements, micro-computed tomography of intact leaves, and spatially explicit modeling of the outside-xylem pathways to evaluate the role of vein embolism and Kleaf in the responses of two different grapevine cultivars to drought. Cabernet Sauvignon and Chardonnay exhibited similar vulnerabilities of Kleaf and gs to dehydration, decreasing substantially prior to leaf xylem embolism. Kleaf and gs decreased by 80% for both cultivars by Ψ leaf approximately –0.7 MPa and –1.2 MPa, respectively, while leaf xylem embolism initiated around Ψ leaf = –1.25 MPa in the midribs and little to no embolism was detected in minor veins even under severe dehydration for both cultivars. Modeling results indicated that reduced membrane permeability associated with a Casparian-like band in the leaf vein bundle sheath would explain declines in Kleaf of both cultivars. We conclude that during moderate water stress, changes in the outside-xylem pathways, rather than xylem embolism, are responsible for reduced Kleaf and gs. Understanding this mechanism could help to ensure adequate carbon capture and crop performance under drought.
The abscisic acid receptor OsPYL6 confers drought tolerance to indica rice through dehydration avoidance and tolerance mechanisms
Authors: Santosh Kumar V V , Yadav Shashank Kumar , Verma Rakesh Kumar , Shrivastava Sanya , Ghimire Omprakash , Pushkar Suchitra , Rao Mandali Venkateswara , Senthil Kumar Thiruppathi , Chinnusamy Viswanathan
Published: October 2020

Abscisic acid (ABA) is a key regulator of plant development and stress tolerance. Here we report functional validation of the ABA receptor OsPYL6 by constitutive and stress-inducible overexpression and RNAi silencing, in an indica rice cultivar ‘Pusa Sugandh 2’. Overexpression of OsPYL6 conferred ABA hypersensitivity during germination and promoted total root length. Overexpression and RNAi silencing of OsPYL6 resulted in enhanced accumulation of ABA in seedlings under non-stress conditions, at least, in part through up-regulation of different 9-cis epoxycarotenoid dioxygenase (NCED )genes. This suggests that PYL6 expression is crucial for ABA homeostasis. Analysis of drought tolerance of OsPYL6 transgenic and wild type plants showed that OsPYL6 overexpression enhanced the expression of stress-responsive genes and dehydration tolerance. Transgenic rice plants overexpressing OsPYL6 with AtRD29A (Arabidopsis thaliana Responsive to Dehydration 29A) promoter also exhibited about 25% less whole plant transpiration, compared with wild type plants under drought, confirming its role in activation of dehydration avoidance mechanisms. However, overexpression of PYL6 reduced grain yield under non-stress conditions due to reduction in height, biomass, panicle branching and spikelet fertility. RNAi silencing of OsPYL6 also reduced grain yield under drought. These results showed that rice OsPYL6 is a key regulator of plant development and drought tolerance, and fine-tuning of its expression is critical for improving yield and stress tolerance.
A guide to plant TPX2-like and WAVE-DAMPENED2-like proteins
Authors: Smertenko Andrei , Clare Shaun J , Effertz Karl , Parish Alyssa , Ross Austin , Schmidt Sharol
Published: October 2020

TPX2 proteins were first identified in vertebrates as a key mitotic spindle assembly factor. Subsequent studies demonstrated that TPX2 is an intricate protein, with functionally and structurally distinct domains and motifs including Aurora kinase-binding, importin-binding, central microtubule-binding, and C-terminal TPX2 conserved domain, among others. The first plant TPX2-like protein, WAVE-DAMPENED2, was identified in Arabidopsis as a dominant mutation responsible for reducing the waviness of roots grown on slanted agar plates. Each plant genome encodes at least one ‘canonical’ protein with all TPX2 domains and a family of proteins (20 in Arabidopsis) that diversified to contain only some of the domains. Although all plant TPX2-family proteins to date bind microtubules, they function in distinct processes such as cell division, regulation of hypocotyl cell elongation by hormones and light signals, vascular development, or abiotic stress tolerance. Consequently, their expression patterns, regulation, and functions have diverged considerably. Here we summarize the current body of knowledge surrounding plant TPX2-family proteins.
Faint LAEs near z > 4.7 C iv absorbers revealed by MUSE
Authors: Díaz C G , Ryan-Weber E V , Karman W , Caputi K I , Salvadori S , Crighton N H , Ouchi M , Vanzella E
Published: October 2020

We present the results from the search for Lyman alpha emitters (LAEs) in the proximity of 11 C iv absorption systems at z > 4.7 in the spectrum of the QSO J1030+0524, using data from Multi-Unit Spectroscopic Explorer. We have found multiple LAE candidates close to four C iv systems at $z_{{\rm{C {\small IV}}}}=4.94$–5.74 with $\log _{10}(N_{{\rm{C {\small IV}}}}[$cm−2]) > 13.5. At z = 5–6, C iv systems with W$_0({\rm{C {\small IV}}})\gt 0.2$ Å seem more likely to have galaxies with Ly α emission within ρ < 200 proper kpc (4/5 cases) than the C iv systems with W$_0({\rm{C {\small IV}}})\lt 0.2$ Å (0/6 cases). The impact parameter of LAE–C iv systems with equivalent widths W0(C iv) > 0.5 Å is in the range $11\, \lesssim \, \rho \, \lesssim \, 200$ proper kpc (pkpc). Furthermore, all candidates are in the luminosity range 0.18–1.15 L$^{\star }_{\rm{{Ly\alpha}}}(z=5.7)$, indicating that the environment of C iv systems within 200 pkpc is populated by the faint end of the Ly α luminosity function. We report a 0.28 L$^{\star }_{\rm{{Ly\alpha}}}$ galaxy at a separation of ρ = 11 pkpc from a strong C iv absorption ($\log _{10}(N_{{\rm{C {\small IV}}}}[$cm−2]) = 14.52) at $z_{{\rm{C {\small IV}}}}=5.72419$. The prevalence of sub-L$^{\star }_{\rm{{Ly\alpha}}}$ galaxies in the proximity of z > 4.9 C iv systems suggest that the absorbing material is rather young, likely ejected in the recent past of the identified galaxies. The connection between faint LAEs and high-ionization absorption systems reported in this work is potentially a consequence of the role of low-mass galaxies in the early evolution of the circum-galactic and intergalactic media.
The completed SDSS-IV extended Baryon Oscillation Spectroscopic Survey: large-scale structure catalogues and measurement of the isotropic BAO between redshift 0.6 and 1.1 for the Emission Line Galaxy Sample
Authors: Raichoor Anand , de Mattia Arnaud , Ross Ashley J , Zhao Cheng , Alam Shadab , Avila Santiago , Bautista Julian , Brinkmann Jonathan , Brownstein Joel R , Burtin Etienne , Chapman Michael J , Chuang Chia-Hsun , Comparat Johan , Dawson Kyle S , Dey Arjun , du Mas des Bourboux Hélion , Elvin-Poole Jack , Gonzalez-Perez Violeta , Gorgoni Claudio , Kneib Jean-Paul , Kong Hui , Lang Dustin , Moustakas John , Myers Adam D , Müller Eva-Maria , Nadathur Seshadri , Newman Jeffrey A , Percival Will J , Rezaie Mehdi , Rossi Graziano , Ruhlmann-Kleider Vanina , Schlegel David J , Schneider Donald P , Seo Hee-Jong , Tamone Amélie , Tinker Jeremy L , Tojeiro Rita , Vivek M , Yèche Christophe , Zhao Gong-Bo
Published: October 2020

We present the Emission Line Galaxy (ELG) sample of the extended Baryon Oscillation Spectroscopic Survey from the Sloan Digital Sky Survey IV Data Release 16. We describe the observations and redshift measurement for the 269 243 observed ELG spectra, and then present the large-scale structure catalogues, used for the cosmological analysis, and made of 173 736 reliable spectroscopic redshifts between 0.6 and 1.1. We perform a spherically averaged baryon acoustic oscillations (BAO) measurement in configuration space, with density field reconstruction: the data two-point correlation function shows a feature consistent with that of the BAO, the BAO model being only weakly preferred over a model without BAO (Δχ2 < 1). Fitting a model constrained to have a BAO feature provides a 3.2 per cent measurement of the spherically averaged BAO distance DV(zeff)/rdrag = 18.23 ± 0.58 at the effective redshift zeff = 0.845.
Interpreting correlated observations of cosmic rays and gamma-rays from Centaurus A with a proton blazar inspired model
Authors: Banik Prabir , Bhadra Arunava , Bhattacharyya Abhijit
Published: October 2020

The nearest active radio galaxy Centaurus (Cen) A is a gamma-ray emitter in GeV–TeV energy scale. The high energy stereoscopic system (HESS) and non-simultaneous Fermi–Large Area Telescope observation indicate an unusual spectral hardening above few GeV energies in the gamma-ray spectrum of Cen A. Very recently the HESS observatory resolved the kilo parsec (kpc)-scale jets in Centaurus A at TeV energies. On the other hand, the Pierre Auger Observatory (PAO) detects a few ultrahigh energy cosmic ray (UHECR) events from Cen-A. The proton blazar inspired model, which considers acceleration of both electrons and hadronic cosmic rays in active galactic nuclei (AGN) jet, can explain the observed coincident high-energy neutrinos and gamma-rays from Ice-cube detected AGN jets. Here, we have employed the proton blazar inspired model to explain the observed GeV–TeV gamma-ray spectrum features including the spectrum hardening at GeV energies along with the PAO observation on cosmic rays from Cen-A. Our findings suggest that the model can explain consistently the observed electromagnetic spectrum in combination with the appropriate number of UHECRs from Cen A.
A new lepto-hadronic model applied to the first simultaneous multiwavelength data set for Cygnus X–1
Authors: Kantzas D , Markoff S , Beuchert T , Lucchini M , Chhotray A , Ceccobello C , Tetarenko A J , Miller-Jones J C A , Bremer M , Garcia J A , Grinberg V , Uttley P , Wilms J
Published: October 2020

Cygnus X–1 is the first Galactic source confirmed to host an accreting black hole. It has been detected across the entire electromagnetic spectrum from radio to GeV gamma-rays. The source’s radio through mid-infrared radiation is thought to originate from the relativistic jets. The observed high degree of linear polarization in the MeV X-rays suggests that the relativistic jets dominate in this regime as well, whereas a hot accretion flow dominates the soft X-ray band. The origin of the GeV non-thermal emission is still debated, with both leptonic and hadronic scenarios deemed to be viable. In this work, we present results from a new semi-analytical, multizone jet model applied to the broad-band spectral energy distribution of Cygnus X–1 for both leptonic and hadronic scenarios. We try to break this degeneracy by fitting the first-ever high-quality, simultaneous multiwavelength data set obtained from the CHOCBOX campaign (Cygnus X–1 Hard state Observations of a Complete Binary Orbit in X-rays). Our model parametrizes dynamical properties, such as the jet velocity profile, the magnetic field, and the energy density. Moreover, the model combines these dynamical properties with a self-consistent radiative transfer calculation including secondary cascades, both of leptonic and hadronic origin. We conclude that sensitive TeV gamma-ray telescopes like Cherenkov Telescope Array (CTA) will definitively answer the question of whether hadronic processes occur inside the relativistic jets of Cygnus X–1.
Modelling long-period variables – II. Fundamental mode pulsation in the non-linear regime
Authors: Trabucchi Michele , Wood Peter R , Mowlavi Nami , Pastorelli Giada , Marigo Paola , Girardi Léo , Lebzelter Thomas
Published: October 2020

Long-period variability in luminous red giants has several promising applications, all of which require models able to accurately predict pulsation periods. Linear pulsation models have proven successful in reproducing the observed periods of overtone modes in evolved red giants, but they fail to accurately predict their fundamental mode (FM) periods. Here, we use a 1D hydrodynamic code to investigate the long-period variability of M-type asymptotic giant branch stars in the non-linear regime. We examine the period and stability of low-order radial pulsation modes as a function of mass and radius, and find overtone mode periods in complete agreement with predictions from linear pulsation models. In contrast, non-linear models predict an earlier onset of dominant FM pulsation, and shorter periods at large radii. Both features lead to a substantially better agreement with observations that we verify against OGLE and Gaia data for the Magellanic Clouds. We provide simple analytical relations describing the non-linear FM period–mass–radius relation. Differences with respect to linear predictions originate from the readjustment of the envelope structure induced by large-amplitude pulsation. We investigate the impact of turbulent viscosity on linear and non-linear pulsation, and probe possible effects of varying metallicity and carbon abundance.
Black widow formation by pulsar irradiation and sustained magnetic braking
Authors: Ginzburg Sivan , Quataert Eliot
Published: October 2020

Black widows are millisecond pulsars with low-mass companions, a few per cent the mass of the sun, on orbits of several hours. These companions are presumably the remnants of main-sequence stars that lost their mass through a combination of Roche lobe overflow and ablation by the host pulsar’s high-energy radiation. While ablation itself is too weak to significantly reduce the mass of the companion star, the ablated wind couples to its magnetic field, removes orbital angular momentum, and thus maintains stable Roche lobe overflow. We use the mesa stellar evolution code, complemented by analytical estimates, to track initially main-sequence companions as they are reduced to a fraction of their original mass by this ablation-driven magnetic braking. We argue that magnetic braking remains effective even for low-mass companions. A key ingredient of our model is that the irradiating luminosity of the pulsar Lirr deposits energy in the companion’s atmosphere and thereby slows down its Kelvin–Helmholtz cooling. We find that the high-energy luminosities measured by Fermi  $L_{\rm irr}=0.1\rm {-}3$ L⊙ can explain the span of black widow orbital periods. The same Lirr range reproduces the companions’ night-side temperatures, which cluster around 3000 K, as inferred from optical light curves.
First Light And Reionization Epoch Simulations (FLARES) – I. Environmental dependence of high-redshift galaxy evolution
Authors: Lovell Christopher C , Vijayan Aswin P , Thomas Peter A , Wilkins Stephen M , Barnes David J , Irodotou Dimitrios , Roper Will
Published: October 2020

We introduce the First Light And Reionisation Epoch Simulations (FLARES), a suite of zoom simulations using the EAGLE model. We resimulate a range of overdensities during the Epoch of Reionization (EoR) in order to build composite distribution functions, as well as explore the environmental dependence of galaxy formation and evolution during this critical period of galaxy assembly. The regions are selected from a large $(3.2 \, \mathrm{cGpc})^{3}$ parent volume, based on their overdensity within a sphere of radius 14 h−1 cMpc. We then resimulate with full hydrodynamics, and employ a novel weighting scheme that allows the construction of composite distribution functions that are representative of the full parent volume. This significantly extends the dynamic range compared to smaller volume periodic simulations. We present an analysis of the galaxy stellar mass function (GSMF), the star formation rate distribution function (SFRF), and the star-forming sequence (SFS) predicted by FLARES, and compare to a number of observational and model constraints. We also analyse the environmental dependence over an unprecedented range of overdensity. Both the GSMF and the SFRF exhibit a clear double-Schechter form, up to the highest redshifts (z = 10). We also find no environmental dependence of the SFS normalization. The increased dynamic range probed by FLARES will allow us to make predictions for a number of large area surveys that will probe the EoR in coming years, carried out on new observatories such as Roman and Euclid.