bluuebunny/crossref_metadata_2025 huggingface dataset:
Climate change induced human displacement in Bangladesh: Implications on the livelihood of displaced riverine island dwellers and their adaptation strategies
Authors: Hossain Babul , Shi Guoqing , Ajiang Chen , Sarker Md. Nazirul Islam , Sohel Md. Salman , Sun Zhonggen , Yang Qi
Published: October 2022

In Bangladesh, many people are being displaced in riverine island (char) areas every year due to climate change and its associated natural catastrophes. This study intends to investigate the impact of climate change on internally displaced char people’s lives and livelihoods along with local adaptation strategies and hindrances to the coping mechanism. Data have been collected from 280 internally displaced households in two sub-districts. A mixed-method approach has been considered combined with qualitative and quantitative methods. The results disclose that frequent flooding, riverbank erosion, and crop loss are the leading causes for relocation, and social relations are impeded in the new place of residence. Increasing summer and winter temperatures, recurrent flooding, severity of riverbank erosion, and expanding disease outbreaks are also important indicators of climate change identified by displaced people, which are consistent with observed data. This study also reveals that almost all households come across severe livelihood issues like food shortage, unemployment and income loss, and housing and sanitation problems due to the changing climate associated with disasters in the former and present places. In response to this, the displaced people acclimatize applying numerous adaptation strategies in order to boost the livelihood resilience against climate change. However, fragile housing, financial conditions, and lack of own land are still the highest impediments to the sustainability of adaptation. Therefore, along with the government, several organizations should implement a dynamic resettlement project through appropriate scrutiny to eradicate the livelihood complications of internally displaced people.
Perceptions of social norms around healthy and environmentally-friendly food choices: Linking the role of referent groups to behavior
Authors: Çoker Elif Naz , Jebb Susan A. , Stewart Cristina , Clark Michael , Pechey Rachel
Published: October 2022

Referent groups can moderate the perception of social norms and individuals’ likelihood to model these norms in food choice contexts, including vegetable intake and reduced meat consumption. The present study investigated whether having a close vs. a distant social group as the referent changed perceptions of social norms around making healthy and eco-friendly food choices. It also assessed whether these changes were associated with a difference in the health and environmental impacts of food choice in a virtual grocery shopping task. A nationally representative sample of UK adults (N = 2,488) reported their perceptions of making healthy and eco-friendly food choices being the norm among people they share meals with (close referent group) and most people in the UK (distant referent group). The former was more commonly perceived to be making both healthy (Z = −12.0, p < 0.001) and eco-friendly (Z = −13.27, p < 0.001) food choices than the latter. Perceptions of norms referring to the close group were significantly associated with the environmental (β = −0.90, 95% CIs: −1.49, −0.28) and health (β = −0.38 p < 0.05, 95% CIs: −0.68, −0.08) impacts of participants’ food choices in a virtual shopping task. No such relationship was found for norms referring to the distant group for both environmental (β =0.43, p > 0.05, 95% CIs: −1.12, 0.25) and health (β = −0.06, p > 0.05, 95% CIs: −0.37, 0.25) impacts. Framing social norms around making healthy and eco-friendly food choices to refer to a close referent group may change their perceptions and ability to encourage sustainable and healthy food purchasing.
Teaching style and academic engagement in pre-service teachers during the COVID-19 lockdown: Mediation of motivational climate
Authors: López-García Ginés D. , Carrasco-Poyatos María , Burgueño Rafael , Granero-Gallegos Antonio
Published: October 2022

COVID-19 and the resulting confinement has had a great impact on the educational environment. Although research in initial teacher education has focused on studying the factors that lead to increased academic engagement, there is no evidence that examines the role of teacher interpersonal style and motivational classroom in a virtual learning context. The aim of this research was to analyze the mediating role of motivational climate between teacher interpersonal style (i.e., autonomy support and controlling style) and academic engagement climate in pre-service teachers in a resilient context. The research design was observational, descriptive, cross-sectional, and non-randomized. A total of 1,410 university students (pre-service teachers) participated (Mage = 23.85; SD = 5.13) (59.6% female; 40.3% male; 0.1% other). The scales of interpersonal teaching style, classroom motivational climate, academic commitment, and resilience were used, and a structural equation analysis with latent variables was carried out controlling resilience and gender. The results of the structural equation model show the importance of student perception of teacher autonomy support on academic engagement of the pre-service teachers, as well as the mediation of the mastery climate between autonomy support and academic engagement. For this reason, in order to increase academic engagement in pre-service teachers, it is recommended the use of motivating styles and instructional strategies focused on supporting the decision-making process, initiative, and significant learning.
The cumulative effect of chronic stress and depressive symptoms affects heart rate in a working population
Authors: Lutin Erika , Schiweck Carmen , Cornelis Jan , De Raedt Walter , Reif Andreas , Vrieze Elske , Claes Stephan , Van Hoof Chris
Published: October 2022

Background

Chronic stress and depressive symptoms have both been linked to increased heart rate (HR) and reduced HR variability. However, up to date, it is not clear whether chronic stress, the mechanisms intrinsic to depression or a combination of both cause these alterations. Subclinical cases may help to answer these questions. In a healthy working population, we aimed to investigate whether the effect of chronic stress on HR circadian rhythm depends on the presence of depressive symptoms and whether chronic stress and depressive symptoms have differential effects on HR reactivity to an acute stressor.

Methods

1,002 individuals of the SWEET study completed baseline questionnaires, including psychological information, and 5 days of electrocardiogram (ECG) measurements. Complete datasets were available for 516 individuals. In addition, a subset (n = 194) of these participants completed a stress task on a mobile device. Participants were grouped according to their scores for the Depression Anxiety Stress Scale (DASS) and Perceived Stress Scale (PSS). We explored the resulting groups for differences in HR circadian rhythm and stress reactivity using linear mixed effect models. Additionally, we explored the effect of stress and depressive symptoms on night-time HR variability [root mean square of successive differences (RMSSD)].

Results

High and extreme stress alone did not alter HR circadian rhythm, apart from a limited increase in basal HR. Yet, if depressive symptoms were present, extreme chronic stress levels did lead to a blunted circadian rhythm and a lower basal HR. Furthermore, blunted stress reactivity was associated with depressive symptoms, but not chronic stress. Night-time RMSSD data was not influenced by chronic stress, depressive symptoms or their interaction.

Conclusion

The combination of stress and depressive symptoms, but not chronic stress by itself leads to a blunted HR circadian rhythm. Furthermore, blunted HR reactivity is associated with depressive symptoms and not chronic stress.
Alterations in innate immune defense distinguish first-episode schizophrenia patients from healthy controls
Authors: Chen Song , Gou Mengzhuang , Chen Wenjin , Xiu Meihong , Fan Hongzhen , Tan Yunlong , Tian Li
Published: October 2022

Innate immune components involved in host defense have been implicated in schizophrenia (SCZ). However, studies exploring their clinical utility in SCZ diagnosis are limited. The main purpose of this study was to evaluate whether circulating endotoxin, high mobility group box 1 protein (HMGB1) and complement component 4 (C4) could act as peripheral biomarkers to distinguish first-episode schizophrenia (FES, n = 42) patients from healthy controls (HCs, n = 35) in associations with psychopathological symptoms and cognitive dysfunctions. Also, their changes after 8-week antipsychotic treatment were investigated. The Positive and Negative Syndrome Scale (PANSS), Psychotic Symptom Rating Scale (PSYRATS), and MATRICS Consensus Cognitive Battery (MCCB) were administered. Receiver operating characteristic (ROC) curves were conducted to evaluate the diagnostic effectiveness of the three biological indicators. Compared to HCs, levels of endotoxin, HMGB1, and C4 were remarkably increased in FES patients after controlling for age, gender, body mass index (BMI) and education years, and the combination of the three biomarkers demonstrated desirable diagnostic performance (AUC = 0.933). Moreover, the endotoxin level was positively correlated with the severity of auditory hallucinations. After 8 weeks of treatment, HMGB1 was decreased significantly in patients but still higher than that in HCs, whereas endotoxin and C4 did not change statistically. The baseline levels of endotoxin, HMGB1, and C4, as well as their changes were not associated with changes in any PANSS subscale score and total score. Our preliminary results suggest that a composite peripheral biomarker of endotoxin, HMGB1, and C4 may have accessory diagnostic value to distinguish SCZ patients from HCs. Additionally, endotoxin might be implicated in the pathogenesis of auditory hallucinations.
The symptoms of postpartum depression observed by family members: A pilot study
Authors: Nguyen Huong Thi Thanh , Do Ly Thi Kim , Pham Huong Thi Thu , Hoang Anh Phuong , Truong Hoa Thi , Nguyen Huyen Thi Hoa
Published: October 2022

Postpartum Depression (PPD) is a burden on women's mental health after delivery, predominantly occurring in the 1st year. PPD poses a threat to the mother's life and affects the quality of childcare. Early detection by family members of depressive symptoms is critical. This study aimed to examine the role of family members in reporting depressive symptoms of PPD among new mothers. A cross-sectional study was conducted, where 56 family members were asked to report depressive symptoms observed in new mothers. At the same time, the new mothers were also screened for PPD using the Edinburgh Postpartum Depression Scale (EPDS). Binary logistic regression was performed. Depressive symptoms of new mothers reported by family members, including emotional and behavioral disturbance, being under stress, high anxiety, isolation, changing lifestyle, and inability to take care of their children, were found as predictors of PPD.
Post-traumatic stress disorder among Syrian refugees in Greece
Authors: Theofanidis Dimitrios , Karavasileiadou Savvato , Almegewly Wafa Hamad
Published: October 2022

Background

Post-Traumatic Stress Disorder (PTSD) is a psychiatric entity developed by those who have been through a traumatic experience. The civil wars in Syria and neighboring countries during the past few years might trigger such experiences, and the same could be argued for the difficult journey from the actual war zones to Europe.

Purpose

To determine the level of PTSD among Arabic-speaking refugees in a Greek refugee camp, who originate primarily from Syria.

Methods

This study involves (N = 73) Syrian refugees, all located in Greek camp. Data were gathered using the civilian version of PTSD CheckList (PCL-C). The Arabic version of the PCL-C was used. Individual scores were evaluated via use of DSM-IV criteria.

Results

PTSD was found in 58 participants, afflicting both genders (72% of men and 45% of women). In addition, the severity score was recorded to be significantly elevated for the majority of the participants. Finally, the most vulnerable age group was the same for both genders, featuring those between the ages of 35 and 44 years.

Conclusions

The findings of this study demonstrated that the traumatic experiences, suffered by these refugees either before and/or on their journey to Greece, had a severe mental impact. It is imperative that all refugees suffering from this disorder be diagnosed in time and receive appropriate support.
The dyadic care experiences of elderly individuals with disabilities and caregivers in the home setting from the perspective of family resilience: A qualitative study
Authors: Abulaiti Bahaerguli , Zhang Xiangchun , Guan Tingyu , Wang Meng , Jia Shoumei , Wang Anni
Published: October 2022

Background

China is one of the most rapidly aging countries in Asia, and nearly 90% of elderly individuals with disabilities choose to receive traditional, family-based, long-term care. A majority of family caregivers have insufficient care capacity and experience physical and emotional distress, which in turn affects the elderly.

Objective

To describe the dyadic care experiences of elderly individuals with disabilities and their caregivers from the perspective of family resilience.

Methods

A phenomenological research method was used. Semi-structured, in-depth, face-to-face interviews with 9 dyads of elderly people with disabilities and their families were conducted from August 2020 to February 2021. The Colaizzi method was used to analyze, summarize, and refine the interview data.

Results

The dyadic care experiences of elderly individuals with disabilities and their caregivers can be summarized in terms of two themes. Theme 1 is dyadic pressure, which includes the following subthemes: (1) substantial objective burden; (2) dual negative experiences, i.e., the perceived low value of elderly individuals and low positive gains by caregivers; and (3) dyadic emotional transmission. Theme 2 is dyadic cooperative coping, which includes the following subthemes: (1) adjustment of family beliefs, including by giving meaning to stress, maintaining a positive outlook toward the future and ensuring spiritual sustentation; (2) changes in family patterns, including flexible adjustment of family patterns and multichannel utilization of social resources; and (3) improvement of family communication, including effective information transmission, rational emotional expression and emotional connection, and cooperation to solve and prevent problems.

Conclusion

Elderly individuals with disabilities and their family caregivers face multiple physical, psychological, and social difficulties and demands during daily care, in which context negative experiences exert influence on this dyad. They collaborate to exhibit family resilience via the adaptation and improvement of family beliefs, family patterns and family communication. The family as a unit expends a great deal of effort to adapt to conditions of stress in the context of caring and shows family resilience, which is closely related to the family's cultural background and community situation. Dyadic resilience-based interventions can be developed based on core elements found by this study.
Quality aspects relating to giving birth in Switzerland: An analysis of quality indicators in inpatient obstetrics from 2013 to 2017
Authors: Moser Dominik
Published: October 2022

Quality transparency supports the reduction of information asymmetries in the health care system and enables the targeted regulation of health care. This study examines quality variation in inpatient obstetric care using the official Federal Office of Public Health Inpatient Quality Indicators (CH-IQI; vaginal births with 3rd- and 4th-degree perineal tears, vaginal births with episiotomy, and Caesarean section for low-risk births). It includes 101 maternity hospitals and 425,810 births between 2013 and 2017. For births with perineal laceration of 3rd and 4th degree, Switzerland performs 0.9% poorer in comparison to Germany (D-IQI) and Austria (A-IQI). For births with episiotomy, Switzerland is 1.1% above Germany. The Caesarean section rate for low-risk births was 26.8% in Switzerland in 2017 (Germany: 25.9%). When comparing Swiss clinics, private clinic locations in particular stand out. One possible reason for this may be the density of care, patient demands or the system of affiliated physicians at these clinics.
Health information system concept in health services in the national health insurance (JKN) era in Indonesia: An environment and one health approach
Authors: Herawati Maria Holly , Idaiani Sri , Maryati  , Fitriana  , Lucitawati  , Veruswati Meita , Hoekstra Karina , Asyary Al
Published: October 2022

The health information system is a component of the healthcare system. The health information system in health services in Indonesia has experienced many problems in getting support for policy making, the implementation of the industrial revolution 4.0, and national health insurance (JKN). To answer the above problems, it is necessary to make a concept of health information systems in health services that based on environment and one health perspectives. This research was part of the thematic research of the 2019 JKN National Health Facilities Survey (Rifaskes) in Indonesia. The systems approach and cross-sectional research were carried out by collecting quantitative data. A structural equation model with Lisrel 88 software was used to model the health information system. The health information system produced a concept that included the following structured input components: governance, human resources, infrastructure, types of information system (IS) (program, JKN, management), and financing; process components: funding, technical guidance, and verification and validation; and output components: open access, standards and quality, utilization, bridging, and security. The concept for strengthening the health information system prioritizes improving the output components (standards, utilization, bridging, open access, and security) in the process components (funding, verification, technical guidance) while the input components (financing, human resources, governance, IS programs, infrastructure, IS JKN, IS management).
Prevalence and correlates of cigarette smoking among Dulong adults in China: A cross-sectional survey in 2020
Authors: Shao Ying , Zha Shun , Qin Mingfang , Zhu Qiuyan , Yang Xiliang , Yang Cangjiang , Wang Xinlin , Zhang Yanli , Yang Weimei , Zhou Kunhua , Li Yanmei , Tang Xian , Yu Qiuli
Published: October 2022

Background

The Dulong people are one of the minorities in China with the lowest population. In recent years, the lifestyle of the Dulong people has also changed drastically due to income growth and urbanization. This study aims to identify cigarette smoking prevalence and potential risk factors among Dulong adults in China.

Methods

This study was conducted among 1,018 adults based on the Dulong Health Status Investigation and Evaluation (DHSIE) in Gongshan Dulong and Nu Autonomous County of Yunnan province, Southwest China. A cross-sectional design and face-to-face questionnaire were used to collect cigarette smoking habits and demographic information. Data were weighted by post-stratification weights according to the age and gender composition of Dulong resident. We also analyzed univariate and multivariate unconditional logistic regression to explore current smoking correlates.

Results

The weighted prevalence of ever-smoking, currently smoking, and formerly smoking among Dulong adults is 31.3, 27.7, and 3.6%, respectively. The prevalence of ever-smoking and currently smoking among male participants (57.0 and 50.6%) is much higher than that of female participants (4.0 and 3.4%). Nearly 60% of ever-smokers and current smokers smoked more than 20 cigarettes per day, which are higher than former smokers (35.2%). Among current smokers, 33.1% relapsed, and 28.3% intend to quit smoking. By adjusting for potential confounding variables, multiple logistic regression analysis indicated that male participants (OR = 48.982, 95% CI: 25.026–95.869) and current drinkers (OR = 4.450, 95% CI: 2.556–7.746) are more likely to be current smokers. On the contrary, current smokers are also more likely to be exposed to secondhand smoke (OR = 4.269, 95% CI: 2.330–7.820) and have a higher risk of chronic respiratory disease (OR = 4.955, 95% CI: 1.669–14.706).

Conclusion

Cigarette smoking is highly prevalent among the Dulong people in Southwest China. An appropriate and effective tobacco control strategy is an urgent need for this population.
Sleep quality and creativity in Chinese college student during the COVID-19 pandemic: The mediating role of executive function
Authors: Guo Botang , Song Yue , Zhao Lu , Cheng Xinhui , Ma Hanze , Qiu Xiaohui , Yang Xiuxian , Qiao Zhengxue , Zhao Erying , Bu Tianyi , Yang Jiarun , Mishra Rupam , Yang Yanjie , Zhou Jiawei
Published: October 2022

Background

COVID-19 has impacted adolescents' interpersonal relationships, life attitudes, and mental health during the past 3 years. However, previous studies predominantly focused on negative problems, while few studies assessed the situation of teenagers from the perspective of positive psychology. Therefore, this study explores the creativity level of Chinese college students during the COVID-19 pandemic, the relationship between sleep quality and creativity, and the mediating role of executive function.

Method

A cross-sectional study was conducted across six colleges in Heilongjiang in China, with a sample of 4,258 college students recruited via stratified cluster sampling. Data were collected through an online survey. A mediation model was constructed, and SPSS PROCESS macro was used to analyze the data.

Results

The creativity score of Chinese college students during the COVID-19 pandemic was 106.48 ± 13.61. Correlation analysis demonstrated that sleep quality correlated negatively with creativity (r = −0.08, P < 0.01) but positively with executive function (r=0.45, P < 0.01), whilst executive function correlated negatively with creativity (r = −0.10, P < 0.01). Moreover, the mediation model revealed that executive function partially mediated the relationship between sleep quality and creativity in college students (indirect effect = −0.017, SE = 0.004, 95% CI = [−0.025, −0.008]). Executive function accounted for 48.6% of the variance in college students' creativity.

Conclusion

School administrators should implement measures such as sleep education to enhance students' sleep quality. Concurrently, curriculum and assessment implementation should enhance executive function. Such measures can contribute to improved student creativity, thus helping students overcome the negative emotional impact of the COVID-19 pandemic.
Non-linear association between composite dietary antioxidant index and depression
Authors: Zhao Leiyong , Sun Yiyan , Cao Renshuang , Wu Xueqiang , Huang Tianjiao , Peng Wei
Published: October 2022

Background

Growing evidence has shown that the antioxidant diet is a protective factor against depression. However, the relationship between the Composite Dietary Antioxidant Index (CDAI), an important measure of antioxidant diet, and depression has received little attention. Therefore, we investigated the relationship between CDAI and depression through a cross-sectional analysis of the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2018.

Methods

The association between CDAI and depression was investigated using a weighted multiple logistic regression model with subgroup analysis. Non-linear correlations were explored using fitted smoothing curves. And we used a recursive method to figure out the turning point and build a weighted two-piece linear regression model.

Results

In the multivariate logistic regression model with full adjustment for confounding variables, the ORs (95% CI) for the association between CDAI and depression were 0.83 (0.78, 0.88). Moreover, a non-linear association was found, with 0.16 being the inflection point. Before the inflection point, each unit increase in CDAI was associated with a 30% decrease in the risk of depression. After the inflection point, the risk of depression was found to be reduced by 11% for each unit increase. None of the interactions in all subgroup analyses were statistically significant.

Conclusions

Our study highlighted a negative non-linear association between CDAI and depression in a nationally representative sample of US adults. Further clinical and basic research is needed to explore their association better.
Leveraging artificial intelligence to optimize COVID-19 robust spread and vaccination roll-out strategies in Southern Africa
Authors: Mathaha Thuso , Mafu Mhlambululi , Mabikwa Onkabetse V. , Ndenda Joseph , Hillhouse Gregory , Mellado Bruce
Published: October 2022

The outbreak of coronavirus in the year 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) prompted widespread illness, death, and extended economic devastation worldwide. In response, numerous countries, including Botswana and South Africa, instituted various clinical public health (CPH) strategies to mitigate and control the disease. However, the emergence of variants of concern (VOC), vaccine hesitancy, morbidity, inadequate and inequitable vaccine supply, and ineffective vaccine roll-out strategies caused continuous disruption of essential services. Based on Botswana and South Africa hospitalization and mortality data, we studied the impact of age and gender on disease severity. Comparative analysis was performed between the two countries to establish a vaccination strategy that could complement the existing CPH strategies. To optimize the vaccination roll-out strategy, artificial intelligence was used to identify the population groups in need of insufficient vaccines. We found that COVID-19 was associated with several comorbidities. However, hypertension and diabetes were more severe and common in both countries. The elderly population aged ≥60 years had 70% of major COVID-19 comorbidities; thus, they should be prioritized for vaccination. Moreover, we found that the Botswana and South Africa populations had similar COVID-19 mortality rates. Hence, our findings should be extended to the rest of Southern African countries since the population in this region have similar demographic and disease characteristics.
Coffee: Is It a Friend or a Foe?
Authors: Costa-Camilo Eduardo , Colucas Raquel , Martins Fátima O. , Conde Silvia V.
Published: October 2022

Coffee is not only one of the most consumed drinks in the world, it is also one of the most addicting. Coffee is complex—it is made up of many substances. One of coffee’s components is of special interest to the scientific community: caffeine. Caffeine has several important effects on the body, and these effects differ whether caffeine is taken once in a while or regularly. Also, it has been shown in both animal studies and in humans that, if caffeine is consumed regularly, it might affect several diseases, including diseases of the heart and metabolism.
Soil microbial population as affected by tillage and rice cultivation modes in Stagnic Anthrosols and Lateritic Red Earth soils in Southern China
Authors: Asenso Evans , Wang Zhimin , Kai Tian , Li Jiuhao , Hu Lian
Published: October 2022

The microbial population (MP) is considered to be a relatively important part of soil health, quality, and productivity. Therefore, this study aimed to access the effects of tillage and rice cultivation modes on soil MP in Stagnic Anthrosols and Lateritic Red Earth soils. The treatments were as follows: (i) MDS: land tilled twice with a moldboard plow and hill-seeding of pregerminated seeds with a direct seeding machine of four to six seeds per hill at a planting space of 25 × 15 cm, (ii) RDS: land tilled twice with a rotary tiller and hill-seeding of pregerminated seeds with a direct seeding machine of four to six seeds per hill at a planting space of 25 × 15 cm, (iii) MMT: land tilled twice with a moldboard plow and 15-day-old seedlings were mechanically transplanted with a transplanting machine at a transplanting hill of four to six seedlings and at a transplanting space of 25 × 15 cm, and (iv) RMT: land tilled twice with a rotary tiller and 15-day-old seedlings were mechanically transplanted with a transplanting machine at a transplanting hill of four to six seedlings and a transplanting space of 25 × 15 cm. The findings showed that MDS improved the MP and increases rice yield. MDS showed a high increase in MP in both locations and the rice productivity of 32.81% (1H; first harvest) and 13.91% (2H; second harvest) and 16.48% (1H) and 18.13% (2H) for Zeng-Cheng and Yi-Yang, respectively. In conclusion, MDS was found to be better in improving the MP and increasing rice yield and could be adopted as a suitable approach for improving soil health, quality, and productivity.
Food systems transformations in South America: Insights from a transdisciplinary process rooted in Uruguay
Authors: Juri Silvana , Baraibar Matilda , Clark Laurie Beth , Cheguhem Mauricio , Jobbagy Esteban , Marcone Jorge , Mazzeo Néstor , Meerhoff Mariana , Trimble Micaela , Zurbriggen Cristina , Deutsch Lisa
Published: October 2022

The wicked nature of sustainability challenges facing food systems demands intentional and synergistic actions at multiple scales and sectors. The Southern Cone of Latin America, with its historical legacy of “feeding the world,” presents interesting opportunities for generating insights into potential trajectories and processes for food system transformation. To foster such changes would require the development of collective understanding and agency to effectively realize purposeful and well-informed action toward desirable and sustainable food futures. This in turn demands the transdisciplinary engagement of academia, the private sector, government/policy-makers, community groups, and other institutions, as well as the broader society as food consumers. While the need for contextualized knowledge, priorities and definitions of what sustainable food systems change means is recognized, there is limited literature reporting these differences and critically reflecting on the role of knowledge brokers in knowledge co-production processes. The political nature of these issues requires arenas for dialogue and learning that are cross-sectoral and transcend knowledge generation. This paper presents a case study developed by SARAS Institute, a bridging organization based in Uruguay. This international community of practice co-designed a 3-year multi-stakeholder transdisciplinary process entitled “Knowledges on the Table.” We describe how the process was designed, structured, and facilitated around three phases, two analytical levels and through principles of knowledge co-production. The case study and its insights offer a model that could be useful to inform similar processes led by transdisciplinary communities of practice or bridging institutions in the early stages of transformative work. In itself, it also represents a unique approach to generate a language of collaboration, dialogue, and imagination informed by design skills and methods. While this is part of a longer-term process toward capitalizing on still-unfolding insights and coalitions, we hope that this example helps inspire similar initiatives to imagine, support, and realize contextualized sustainable food system transformations.
Case report and literature review: Malignant adenomyoepithelioma after breast augmentation
Authors: Hu Longqing , Qian Bei , Yan Zhecheng , Bing Kaijian , Mei Li , Qu Xincai
Published: October 2022

Background

Breast malignant adenomyoepithelioma (MAME) after breast augmentation has never been reported.

Case summary

We reported a case of a 55-year-old woman who was diagnosed with breast MAME 16 years after breast augmentation. Breast augmentation was performed on the patient with two 200 ml round textured prostheses in the subpectoral plane through axillary incisions in 2004. However, a breast ultrasound in 2020 revealed a suspicious malignant lump in the right breast, which was finally confirmed as MAME by pathology. Skin-sparing modified radical mastectomy and immediate breast reconstruction with expander implantation were performed. Subsequently, the patient received three cycles of chemotherapy with the regimen of anthracycline and cyclophosphamide. In the following nearly 2 years of follow-up, no tumor recurrence and metastasis were found, and the overall treatment was satisfactory for the patient.

Conclusion

Here, we present a unique case in which a patient was diagnosed with breast MAME after breast augmentation. Skin-sparing modified radical mastectomy and immediate breast reconstruction with expander implantation are feasible approaches that yield at least short-term oncological safety and acceptable aesthetic results. However, whether there is a potential relationship between MAME and breast implants remains to be further explored. Meanwhile, due to the rarity of breast MAME, more authoritative strategies considering both oncological safety and aesthetics to seek better long-term therapeutic effects are needed.
Validation of a color deconvolution method to quantify MSC tri-lineage differentiation across species
Authors: Heyman Emma , Meeremans Marguerite , Devriendt Bert , Olenic Maria , Chiers Koen , De Schauwer Catharina
Published: October 2022

Mesenchymal stem cells (MSCs) are a promising candidate for both human and veterinary regenerative medicine applications because of their abundance and ability to differentiate into several lineages. Mesenchymal stem cells are however a heterogeneous cell population and as such, it is imperative that they are unequivocally characterized to acquire reproducible results in clinical trials. Although the tri-lineage differentiation potential of MSCs is reported in most veterinary studies, a qualitative evaluation of representative histological images does not always unambiguously confirm tri-lineage differentiation. Moreover, potential differences in differentiation capacity are not identified. Therefore, quantification of tri-lineage differentiation would greatly enhance proper characterization of MSCs. In this study, a method to quantify the tri-lineage differentiation potential of MSCs is described using digital image analysis, based on the color deconvolution plug-in (ImageJ). Mesenchymal stem cells from three species, i.e., bovine, equine, and porcine, were differentiated toward adipocytes, chondrocytes, and osteocytes. Subsequently, differentiated MSCs were stained with Oil Red O, Alcian Blue, and Alizarin Red S, respectively. Next, a differentiation ratio (DR) was obtained by dividing the area % of the differentiation signal by the area % of the nuclear signal. Although MSCs isolated from all donors in all species were capable of tri-lineage differentiation, differences were demonstrated between donors using this quantitative DR. Our straightforward, simple but robust method represents an elegant approach to determine the degree of MSC tri-lineage differentiation across species. As such, differences in differentiation potential within the heterogeneous MSC population and between different MSC sources can easily be identified, which will support further optimization of regenerative therapies.
Soil Compaction Drives an Intra-Genotype Leaf Economics Spectrum in Wine Grapes
Authors: Martin Adam R. , Mariani Rachel O. , Cathline Kimberley A. , Duncan Michael , Paroshy Nicholas J. , Robertson Gavin
Published: October 2022

Intraspecific trait variation is a critical determinant of ecosystem processes, especially in agroecosystems where single species or genotypes exist in very high abundance. Yet to date, only a small number of studies have evaluated if, how, or why traits forming the Leaf Economics Spectrum (LES) vary within crops, despite such studies informing our understanding of: (1) the environmental factors that drive crop LES trait variation and (2) how domestication has altered LES traits in crops vs. wild plants. We assess intragenotype variation in LES traits in ‘Chardonnay’ (Vitis vinifera)—one of the world’s most commercially important crops—across a soil compaction gradient: one of the most prominent characteristics of agricultural soils that may drive crop trait variation. Our early evidence indicates that ‘Chardonnay’ traits covary along an intragenotype LES in patterns that are qualitatively similar to those observed among wild plants: resource-acquiring vines expressed a combination of high mass-based photosynthesis (Amass), mass-based dark respiration (Rmass), and leaf nitrogen concentrations (N), coupled with low leaf mass per area (LMA); the opposite set of trait values defined the resource-conserving end of the ‘Chardonnay’ LES. Traits reflecting resource acquisition strategies (Amass, Rmass, and leaf N) declined with greater bulk density, while traits related to investment in leaf construction costs (LMA) increased with greater bulk density. Our findings contribute to an understanding of the domestication syndrome in grapevines and also provide information relevant for quantifying trait-based crop responses to environmental change and gradients.
Automatic Estimation of Apple Orchard Blooming Levels Using the Improved YOLOv5
Authors: Chen Zhaoying , Su Rui , Wang Yuliang , Chen Guofang , Wang Zhiqiao , Yin Peijun , Wang Jinxing
Published: October 2022

The estimation of orchard blooming levels and the determination of peak blooming dates are very important because they determine the timing of orchard flower thinning and are essential for apple yield and quality. In this paper, we propose an orchard blooming level estimation method for global-level and block-level blooming level estimation of orchards. The method consists of a deep learning-based apple flower detector, a blooming level estimator, and a peak blooming day finding estimator. The YOLOv5s model is used as the apple flower detector, which is improved by adding a coordinate attention layer and a small object detection layer and by replacing the model neck with a bidirectional feature pyramid network (BiFPN) structure to improve the performance of the apple flower detector at different growth stages. The robustness of the apple flower detector under different light conditions and the generalization across years was tested using apple flower data collected in 2021–2022. The trained apple flower detector achieved a mean average precision of 77.5%. The blooming level estimator estimated the orchard blooming level based on the proportion of flowers detected at different growth stages. Statistical results show that the blooming level estimator follows the trend of orchard blooming levels. The peak blooming day finding estimator successfully positioned the peak blooming time and provided information for the flower thinning timing decision. The method described in this paper is able to provide orchardists with accurate information on apple flower growth status and is highly automated.
Role of IAA and Primary Metabolites in Two Rounds of Adventitious Root Formation in Softwood Cuttings of Camellia sinensis (L.)
Authors: Wang Shuting , Sun Guodong , Luo Ying , Qian Wenjun , Fan Kai , Ding Zhaotang , Hu Jianhui
Published: October 2022

The type of adventitious root formation of tea softwood cuttings is different from that of single node cuttings. In addition to the callus at the base of cuttings, the adventitious roots are also formed in the upper cortex of softwood cuttings. In order to find out the similarities and differences between the above two types of adventitious roots of softwood cuttings and the influencing factors for the differences, an integrated analysis of plant hormones, untargeted metabolomics, and transcriptomics of the softwood cutting stems at different positions is performed. The phytohormone results show that IAA plays a leading role, and a high ratio of in vivo auxin to GA3 or ABA facilitated root formation. The ratios of IAA/GA3 and IAA/ABA in the upper and base rooting parts of cuttings are both higher than the middle non-rooting transition zone. Differences in metabolites indicate that 73 metabolites are involved in the formation of adventitious roots in cuttings. Compared with the middle non-rooting transition zone, most saccharides are downregulated in the upper and base rooting parts of softwood cuttings, and the saccharides in the base rooting parts of cuttings are more consumed than that in the upper rooting parts. Most organic acids in the callus at the base of cuttings show an upward trend, while those in the upper rooting parts show a downward trend. Furthermore, coniferyl alcohol is the key metabolite for adventitious root formation in the upper and base rooting parts of cuttings. Transcriptome results show 1099 differentially expressed genes (DEGs) are obtained, and KEGG enrichment analysis show that these DEGs are significantly enriched in phenylpropanoid biosynthesis, plant hormone signal transduction, and flavonoid biosynthesis pathways. Based on weighted gene co-expression network analysis (WGCNA), two key modules which have a highly positive correlation with IAA are identified. In summary, maintaining the balance of endogenous hormones and sufficient nutritional elements is very important for adventitious root formation in tea plants. Clarifying the material basis of softwood cutting rooting of tea plant is of great significance to improve the cutting survival rate of tea plant (especially difficult rooting varieties) and shorten the breeding cycle.
Effects of Low-Ambient-Temperature Stimulation on Modifying the Intestinal Structure and Function of Different Pig Breeds
Authors: Guo Yanbo , Liu Ting , Li Wenxia , Zhang Wanfeng , Cai Chunbo , Lu Chang , Gao Pengfei , Cao Guoqing , Li Bugao , Guo Xiaohong , Yang Yang
Published: October 2022

Ambient temperature (Ta) fluctuation is a key factor affecting the growth performance and economic returns of pigs. However, whether the response of intestinal structure and function are related to pig breeds in low Ta has not been investigated yet. In this study, Large White (LW) pigs, Jinfen White (JFW) pigs and Mashen (MS) pigs were raised in artificial climate chambers under normal Ta (25 °C) and low Ta (4 °C) for 96 h. Afterwards, the decrease in body temperature and complete blood counts (CBC) of all pigs were measured. Hematoxylin–eosin, immunohistochemical staining, qPCR and ELISA were used to investigate their intestinal mucosa integrity and inflammatory response. The results showed that MS pigs could maintain a normal body temperature and villus structure after 4 °C stimulation compared with those of LW and JFW pigs. Villus height and villus height/crypt depth of MS pigs were significantly higher than those of LW and JFW pigs at 4 °C. Low-Ta stimulation increased the digestion of carbohydrates of all pigs. Meanwhile, low Ta enhanced the activity of lipase in LW pigs and increased trypsin activity in MS and JFW pigs. Furthermore, low-Ta stimulation significantly downregulated the protein of tight junction and upregulated the mRNA expression of inflammatory cytokines in MS pigs. MS pigs also showed stronger spleen immune function at 4 °C. These results indicated that the local MS pig breed had stronger intestinal function in low Ta by producing a stronger inflammatory response, which lays the foundation for further study on the mechanism of cold tolerance in pigs.
Evaluation of Non-Fermented and Fermented Chinese Chive Juice as an Alternative to Antibiotic Growth Promoters of Broilers
Authors: Lee Woo-Do , Kothari Damini , Moon Seung-Gyu , Kim Jongil , Kim Kyung-Il , Ga Gun-Whi , Kim Yong-Gi , Kim Soo-Ki
Published: October 2022

The present study explores the application of CC juice as a suitable feed additive and alternative to conventional antibiotics. We performed a comparative study to investigate the effects of non-fermented and fermented CC juice on broiler productivity, meat quality, blood characteristics, intestinal characteristics, and microbiota associated with intestinal characteristics. A total of 800 one-day-old Ross 308 broiler chickens were randomly assigned to one of the four dietary treatment groups: (1) basal diet (negative control; NC); (2) basal diet + 0.01% enramycin (positive control; PC); (3) basal diet + 3% non-fermented CC juice (NCC; CC juice 10%, water 90%); and (4) basal diet + 3% fermented CC juice (FCC; CC juice 10%, water 90%, Lactobacillus plantarum SK4719). Feed and water were provided ad libitum. Intriguingly, all treatments showed similar results in terms of broiler productivity and chicken meat quality. Considering organ characteristics, the FCC group showed a low spleen weight and lower (p < 0.05) blood levels of AST and total cholesterol (TCHO). Regarding intestinal characteristics, the CC feed additive (NCC and FCC) resulted in a heavier intestinal weight (p < 0.05) without affecting the length ratio of the villi or the crypt compared to the control (NC or PC). NCC and FCC lowered the growth of intestinal pathogens (p < 0.01). In summary, the addition of FCC can maintain poultry health by improving blood compositions and inhibiting the growth of intestinal pathogens, leading to a productivity comparable to that of poultry treated with growth-promoting antibiotics.
Stenotrophomonas maltophilia, a Pathogen of Increasing Relevance to Dermatologists: A Case Report and Review of the Literature
Authors: Belzer Annika , Weiss Emma , Etaee Farshid , Bunick Christopher , Damsky William , Nelson Caroline
Published: October 2022

Stenotrophomonas maltophilia is a Gram-negative bacillus that causes skin and soft tissue infections (SSTI), as well as bacteremia, pneumonia, and urinary tract infections. S. maltophilia infections are typically nosocomial and are often transmitted through water sources. Although historically described in immunocompromised hosts, S. maltophilia prevalence is increasing in both immunocompromised and immunocompetent populations. In light of high morbidity and mortality, it is critical that dermatologists are aware of this organism because of the limited options for therapy. Here, we describe a case of a S. maltophilia abscess with bacteremia in a patient with chronic lymphocytic leukemia and aplastic anemia that was successfully treated with trimethoprim–sulfamethoxazole. We also review the current standard of care and propose an algorithm for the treatment of S. maltophilia infection.
Cigarette Smoke Impairs Airway Epithelial Wound Repair: Role of Modulation of Epithelial-Mesenchymal Transition Processes and Notch-1 Signaling
Authors: Di Vincenzo Serena , Ninaber Dennis K. , Cipollina Chiara , Ferraro Maria , Hiemstra Pieter S. , Pace Elisabetta
Published: October 2022

Cigarette smoke (CS) induces oxidative stress and chronic inflammation in airway epithelium. It is a major risk factor for respiratory diseases, characterized by epithelial injury. The impact of CS on airway epithelial repair, which involves epithelial-mesenchymal transition (EMT) and the Notch-1 pathway, is incompletely understood. In this study, we used primary bronchial epithelial cells (PBECs) to evaluate the effect of CS on epithelial repair and these mechanisms. The effect of CS and/or TGF-beta1 on wound repair, various EMT and Notch-1 pathway markers and epithelial cell markers (TP63, SCGB1A) was assessed in PBECs cultured submerged, at the air–liquid interface (ALI) alone and in co-culture with fibroblasts. TGF-beta1 increased epithelial wound repair, activated EMT (shown by decrease in E-cadherin, and increases in vimentin, SNAIL1/SNAIL2/ZEB1), and increased Notch-1 pathway markers (NOTCH1/JAGGED1/HES1), MMP9, TP63, SCGB1A1. In contrast, CS decreased wound repair and vimentin, NOTCH1/JAGGED1/HES1, MMP9, TP63, SCGB1A1, whereas it activated the initial steps of the EMT (decrease in E-cadherin and increases in SNAIL1/SNAIL2/ZEB1). Using combined exposures, we observed that CS counteracted the effects of TGF-beta1. Furthermore, Notch signaling inhibition decreased wound repair. These data suggest that CS inhibits the physiological epithelial wound repair by interfering with the normal EMT process and the Notch-1 pathway.