bluuebunny/crossref_metadata_2025 huggingface dataset:
Field investigation of the feasibility of MICP for Mitigating Natural Rainfall-Induced erosion in gravelly clay slope
Authors: Zhang Zhichao , Lu Huaming , Tang Xuefeng , Liu Kan , Ye Longzhen , Ma Guoliang
Published: September 2024

Rainfall-induced erosion on slopes is a prevalent natural process leading to soil loss. One promising application of microbially induced carbonate precipitation (MICP) is to mitigate rainfall-induced erosion. Conducting field tests is an essential step to verify and improve its performance. In the current work, field tests were conducted to assess the feasibility of using MICP to mitigate rainfall-induced erosion on a gravelly clay slope in Longyan, Fujian, China. A temporary laboratory was set up to cultivate bacteria, and a non-sterilizing method was employed to prepare large volumes of bacterial suspensions in a single batch. Slopes were treated by spraying solutions onto their surfaces. The amount of discharged soils and 3D surface scanning results were used for evaluating the erosion intensity of the slopes. The results demonstrated that the method could effectively mitigate the surface erosion caused by natural rainfall and prevent erosion-induced collapse. Notably, approximately one year after the treatment, the grass had started to grow on the heavily cemented slope, indicating that the MICP method is both effective and eco-friendly for soil stabilization method. However, further improvements are needed to enhance the uniformity and long-term durability of the MICP treatment.
Entangled Mathematics as a Tool of Reasoning in the Mid-Twentieth-Century UK Electricity Industry
Authors: Naylor Robert Luke
Published: September 2024

In the mid-twentieth century, the identity of those who oversaw the UK electricity grid tentatively and slowly began to shift from those who joined the electricity industry directly from secondary school to a university-educated elite with a higher level of technical education. At the same time, electricity infrastructure became increasingly centralised, leading to the creation of a national grid in 1938, meaning that control of electricity became concentrated in the hands of an ever-smaller group and increasing the stakes in debates over strategy. By using the case studies of power engineer Paul Schiller and mathematician Maurice Davies, this paper traces how the boundaries of what mathematics could or could not be used for were renegotiated between factions within the UK electricity industry. Schiller unsuccessfully attempted to use mathematics, including the authority of academic mathematicians, to reinforce controversial arguments about the strategic direction of the industry in the 1940s. Such arguments failed to resonate with a class of, as Schiller put it, “practical men” that still held considerable influence. Davies on the other hand was employed by the industry in the 1950s to improve efficiency, and was able to implement lasting measures in this effort by using the weather to forecast electricity demand, and successfully defended the usefulness of his work in the 1970s against colleagues who felt that forecasting could be done better with mathematical models without weather inputs. The contrast between these two stories shows how the influence of mathematical thinking was contingent upon existing power dynamics, and reinforce how the history of mathematics should be socially embedded.
Reproductive dysfunction in seawater provides an environmental barrier to the range expansion of the invasive Neogobius melanostomus into the North Sea
Authors: Green Leon , Griful-Dones Martina , Kvarnemo Charlotta
Published: September 2024

Salinity can shape species’ distributions via physiological costs. Understanding how and when these costs occur can help predict colonisation patterns, for example during species invasions. To understand the impacts of high salinity environments on the ongoing expansion of the invasive round goby (Neogobius melanostomus) towards the North Sea, fish from this invasion front were spawned in a common-garden setup at different salinities. Reproductive adults were acclimated to a control (20 PSU) salinity representing the current invasion front conditions, and a North Sea coastal salinity (30 PSU). In these salinities they were sorted into spawning groups, and spawning attempts and egg development was tracked during 1.5 months. The results showed a strong impact of the 30 PSU salinity treatment, with a complete developmental failure of all clutches spawned in this salinity. The failed clutches resulted in a significant increase of egg consumption by the nest-guarding males. In addition, sperm velocity showed a decrease with increasing salinity when tested in both spawning salinities and at an intermediate level. Few differences in adult physiology were found as a consequence of the salinity treatments. These results show that, despite adult acclimation to North Sea coastal conditions, the gametes of N. melanostomus cannot as of now cope with the salinities into which their spread is currently predicted. Though adaptation or transgenerational acclimation might allow for reproduction in salinities higher than the species currently occupy, we suggest current models to incorporate a reproductive limit for N. melanostomus at a salinity of 30 PSU.
Intervention for School Anxiety and Absenteeism in Children (ISAAC): Mixed-Method Feasibility Study of a Coach-Assisted, Parent-Focused Online Program
Authors: Lester Kathryn J. , McDonald Brontë , Tunks Alice , Michelson Daniel
Published: September 2024

The aftermath of the Covid-19 pandemic has seen an increase in persistent school absenteeism and Emotionally-Based School Avoidance (EBSA). However, suitable evidence-based psychological interventions are often unavailable. We aimed to assess the feasibility and acceptability of a new parent-focused online program, Intervention for School Anxiety and Absenteeism in Children (ISAAC), which has been co-designed with parents and practitioners. This exploratory mixed-method study recruited participants from three schools in southern England, enrolling N = 9 parents for whom a child, aged 5–11 years, was experiencing signs of EBSA. The intervention consisted of three web-based psychoeducational modules respectively addressing parental stress, accommodating parenting behaviors, and communication with school staff. Module completion was assisted by weekly calls with a non-specialist “coach.” Feasibility was measured using indicators of retention, module participation, overall program completion and coaching fidelity. Acceptability was assessed using semi-structured interviews, module ratings and written qualitative feedback. We also explored baseline-post change in parent-reported measures of children’s school avoidance, absences, anxiety, parental stress, accommodating parenting behaviors, and quality of parent-school communication. Overall, the intervention was feasible to deliver to parents with six (67%) participants completing the full intervention. Participants found the intervention acceptable across thematic domains of affective attitude, burden, coherence, self-efficacy and perceived effectiveness. Participants particularly appreciated the coach’s support. We observed small to moderate reductions in school avoidance behaviours (d with Hedges correction = 0.36), child anxiety (d with Hedges correction = 0.33) and accommodating behaviours (d with Hedges correction = 0.44) at the post timepoint compared to baseline. In conclusion, ISAAC shows early promise with the potential to deliver scalable online support for families affected by emerging EBSA. Future research should move toward establishing effectiveness in a randomized controlled trial.
Adapting engineering design thinking for sustainability
Authors: Date Geetanjali , Chandrasekharan Sanjay
Published: September 2024

The nature of engineering design thinking needs to change drastically to address the climate crisis, as the technologies and activities that damage the environment are generated by engineering design. Current engineering design practices, as well as engineering design education (EE) pedagogies, are driven by formal knowledge structures, such as mathematical models and optimization techniques, that are far removed from concerns about the environment. To adapt engineering design thinking for sustainability, a clear characterization of the thinking roles played by various design components, including the role of formal structures in sustainable engineering design, is needed. As a first step towards developing this characterization, we investigated the way sustainable micro-hydro power systems were designed by two grassroots technology designers. Our analysis indicated that artifact-based imagination (mental simulation of material structure and dynamics), including artifact-based reasoning (manipulation of imagined artifacts), and synthesis (of requirements and constraints) were key to integrating the eco-social context into the design. Formal structures played a supportive role to these core design thinking processes. To examine the validity of this analysis, we studied two engineering design cases from other areas, exploring whether the patterns we identified using the micro-hydro turbine cases extended to these cases. Results suggested that artifact-based imagination and reasoning and synthesis are common threads across different kinds of engineering design. Based on this finding, we suggest that the ongoing redesign of EE—to support ecological sustainability—needs to focus on artifact-based imagination and synthesis of eco-social factors, in addition to formal structures.
Pyroptosis and chemical classification of pyroptotic agents
Authors: Hara Mohammed A. , Ramadan Mohamed , Abdelhameid Mohammed K. , Taher Ehab S. , Mohamed Khaled O.
Published: September 2024

Pyroptosis, as a lytic-inflammatory type of programmed cell death, has garnered considerable attention due to its role in cancer chemotherapy and many inflammatory diseases. This review will discuss the biochemical classification of pyroptotic inducers according to their chemical structure, pyroptotic mechanism, and cancer type of these targets. A structure-activity relationship study on pyroptotic inducers is revealed based on the surveyed pyroptotic inducer chemotherapeutics. The shared features in the chemical structures of current pyroptotic inducer agents were displayed, including an essential cyclic head, a vital linker, and a hydrophilic tail that is significant for π-π interactions and hydrogen bonding. The presented structural features will open the way to design new hybridized classes or scaffolds as potent pyroptotic inducers in the future, which may represent a solution to the apoptotic-resistance dilemma along with synergistic chemotherapeutic advantage.

Graphical Abstract
Association between sociodemographic variables and delayed patient presentation among surgical neuro-oncology patients in Mexico City: a single institution experience
Authors: Punchak Maria A. , Alvarez-Castro Jose Alfonso , Escalante Jonathan Ramos , Hidalgo Keren Magaly Aguilar , Zamarripa Mauricio Macias , Navarrete Xymena Dominguez , Soto Fernando Castro , Castellanos Mackenzie , Moreno-Jiménez Sergio , Lawton Michael T. , Quinones-Hinojosa Alfredo , Mejía Pérez Sonia Iliana
Published: September 2024

Purpose

Mexico has the second highest incidence of central and peripheral nervous system cancer cases in Latin America, but clinical and research resources to improve oncologic care are biased towards high-income countries. We carried out a retrospective study to identify sociodemographic factors associated with more severe clinical presentation among surgical neuro-oncology who underwent surgery at a major public referral hospital in Mexico City.

Methods

The hospital electronic medical record was reviewed to identify all surgical neuro-oncology patients who underwent surgery between January 1 and December 31, 2022. Descriptive statistics were used to characterize the patient population and outcomes; statistical analysis was performed to determine association between sociodemographic variables and advanced clinical presentation.

Results

A total of 366 neuro-oncology patients underwent surgery during the study period. The median patient age was 48 (IQR 17–83). The majority of patients were female (60.1, n = 220), single (51.4%, n = 188), and 29.2% (n = 107) endorsed being the primary provider for their family. The median number of dependents per patient was 4 (IQR 2–50), while the median monthly income was 10269 Mexican pesos (MXN) (IQR 2000–13500] and the median travel distance to INNN was 49 km (IQR 22–174). On multivariate analyses, having a higher number of dependents was associated with increased odds of presenting with longer symptom duration (p = 0.01). Divorced/separated status was associated with increased odds of presenting with tumors > 35mL in volume (p = 0.04). Primary provider (p = 0.01) and higher average monthly income (p = 0.03) was associated with decreased odds of presenting with tumors > 35mL.

Conclusions

This is the first study to recognize that certain sociodemographic factors are associated with more severe clinical presentation among surgical neuro-oncology patients. Further studies are needed in order to decern specific causes for delayed presentation in this patient population in order to create targeted interventions and decrease delays in care.
Fear to fail and entrepreneurship intent: examining linkages and potential pathways in Senegal
Authors: Ndour Cheikh T. , Asongu Simplice A.
Published: September 2024

This study aims to investigate the effect of fear of failure on entrepreneurship intent. It utilises survey data from the Global Entrepreneurship Monitor (2015) conducted in Senegal. Analysing a sample of 2364 individuals, the probit model was employed, revealing three key findings. Firstly, fear of failure significantly diminishes entrepreneurship intent. Secondly, individuals who are partially employed demonstrate a heightened inclination towards entrepreneurship. Thirdly, fear of failure consistently impacts entrepreneurship intent regardless of gender. A key policy implication of this research is the necessity to address discrimination in policies designed to support individuals with greater entrepreneurial aspirations.
Making Sense of Interlinkages in EU Marine Environment Legislation: Unearthing Effectiveness
Authors: Appleby Thomas , Scott Juliette , Flannery Wesley , Donelan Edward
Published: September 2024

Crises such as water quality, pollution, climate change, overfishing, biodiversity, energy, waste, and carbon sequestration mean that legislation protecting the marine environment is under intense pressure to be effective and to demonstrate positive results in a vast array of public and private spheres. Thus far, scholarship of EU marine environmental law has been focused primarily on (i) interaction with international agreements (ii) spatial/jurisdictional studies (iii) analysis of new laws, plans and programmes (iv) principles (e.g. good environmental status, precautionary approach, polluter pays) (v) CJEU case analysis (vi) enforcement (vii) specific issues (plastics, litter…). However, over the years the mass constituted by the EU marine environment acquis has grown ever-larger, leading to risks of poor coordination, over-regulation in some areas and lack of regulation in others. By triangulating complementary investigatory methodologies, this study teases out systemic, diachronic and legilinguistic interlinkages—within and across key instruments as well as EU institutions, bodies and agencies. Our results provide avenues for policymakers nationally and at EU level to improve the legibility and coherence of marine environmental regulation—to the benefit of citizens and the wider body of stakeholders, and, ultimately, to benefit the marine world.
Environmental life cycle assessment of drink and yoghurt products using non-nutritive sweeteners and sweetness enhancers in place of added sugar: the SWEET project
Authors: Suckling J. , Morse S. , Murphy R. , Raats M. , Astley S. , Ciruelos A. , Crespo A. , Halford J. C. G. , Harrold J. A. , Le-Bail A. , Koukouna E. , Musinovic H. , Raben A. , Roe M. , Scholten J. , Scott C. , Westbroek C.
Published: September 2024

Purpose

There are increasing concerns regarding detrimental health effects of added sugar in food and drink products. Non-nutritive sweeteners (NNS) and sweetness enhancers (SE) are seen as viable alternatives. Much work has been done on health and safety of NNS&SE when consumed in place of sugar, but very little on their sustainability. This work aims to bridge that gap with an environmental study of replacing added sugar with NNS&SE in the context of drink and yoghurt.

Methods

A life cycle assessment (LCA) approach was used to compare environmental impact of a drink and yoghurt, sweetened with sucrose, to those sweetened with NNSs or an SE: stevia rebaudioside A, sucralose, aspartame, neotame, and thaumatin. Primary ingredients data were taken from preparation of foodstuffs for clinical trials. Results are reported via the ReCiPe 2016 (H) method, with focus on land use, global warming potential (GWP), marine eutrophication, mineral resource scarcity, and water consumption. Impacts are reported in terms of 1 kg product. Scenarios explore sensitivity of the LCA results to change in background processes, functional unit, and sweetener type. This research was conducted as part of the EU Horizon 2020 project SWEET (sweeteners and sweetness enhancers: impact on health, obesity, safety, and sustainability).

Results and discussion

Replacing sugar with an NNS or part-replacing with an SE is shown to reduce environmental impact across most impact categories, for example, on a mass basis, GWP for a drink reduces from 0.61 to approx. 0.51 kgCO2-eq/kg and for a yoghurt from 4.15 to approx. 3.73 kgCO2-eq/kg. Variability in environmental impact is shown to be relatively small between the NNSs, indicating that choice of NNS is less important than the reformulation changes required to accommodate the loss of sugar. Reporting impact in terms of calorie density, instead of mass, shows greater reduction in environmental impact when using an NNS or SE and shows how important functional unit is when reporting impact of these products.

Conclusion

This study is the first to compare food or drink products sweetened with sugar, NNS, or SE. Results show that there is great potential to reduce environmental impact of sweetened drinks and yoghurts. Moreover, the choice of NNS does not greatly affect the environmental impact of either product. Therefore, this research shows that choices relating to replacing added sugar may be based more upon health or formulation needs and less on environmental concerns.
Does Philosophy Make Less Progress than Other Academic Fields?
Authors: Maslen Cei
Published: September 2024

This paper looks at different possible measures of progress and argues that we currently have no objective measures which are appropriate for comparing the progress of entire fields. I look at several possible measures, including one measure suggested by Chalmers: increased agreement on correct answers to the big questions in that field. Regarding the question that the title of this paper asks, I think we should remain agnostic; we are not currently able to say whether philosophy makes less progress than other academic fields.
Urban Care for Unpaid Caregivers: Community Voices in the Care Block Program, in Bogotá, Colombia
Authors: Guevara-Aladino Paula , Sarmiento Olga L. , Rubio María Alejandra , Gómez-García Lina María , Doueiri Zakaria Nadeem , Martínez Diego , King Abby C. , Hurtado-Tarazona Adriana , Banchoff Ann , Guzman Luis A. , Álvarez-Rivadulla María José , Palencia Leonardo
Published: September 2024

The Care Block of Bogotá, Colombia, is an urban program that offers services for low-income unpaid caregivers. This study aimed to (i) characterize unpaid caregivers’ subjective well-being, mental health symptoms, physical activity levels, and use of public spaces linked to the Care Block; (ii) identify caregivers’ perceived built and social environment facilitators and barriers to accessing the Care Block facility; and (iii) document the community-led advocacy process to improve the Care Block program. The quantitative component included a subjective well-being and mental health symptoms survey, and the System for Observing Play and Recreation in Communities (SOPARC) instrument. The qualitative component included the Our Voice citizen science method augmented with portable virtual reality equipment to engage participants in advocacy for changes. Participants (median age of 53 years) dedicated a median of 13.8 h a day to unpaid caregiving, had an average subjective well-being score of 7.0, and 19.1% and 23.8% reported having depression and generalized anxiety symptoms respectively. Caregivers reported that the program fosters their perception of purpose, enjoyment, resilience, and cognitive and emotional awareness. SOPARC evaluation showed that most women engaged in moderate to vigorous physical activity. The caregivers highlighted education, physical activity services, and integration of facilities as facilitators to accessing the Care Block program. Poor quality and lack of sidewalks and roads, limited personal safety, and the risk of pedestrian-vehicle collisions were identified as barriers. Virtual Reality sparked compelling dialogue between participants and stakeholders, allowing stakeholders to reflect on an urban program facilitating unpaid care work.
Abortion Ban Advocates and Rape Exception
Authors: Dominiak Ł.
Published: September 2024

The present paper argues that abortion ban advocates can justify an exception for rape. Recently, Blackshaw offered an interesting argument that if abortion ban advocates modified their position along the lines of Thomson’s analysis of rights, they could make an exception for rape. However, doing so would require making concessions they would be unlikely to make, the crucial one being subscribing to an absurd view that abortion in the case of rape is permissible but only if it is performed in a certain way, that is, in a way that withdraws life support from the fetus. Agreeing first with Blackshaw’s premises, we argue that the view in question is hardly absurd. Thus, relying on Boonin’s acknowledgment that although very rare, a position according to which abortion should be legal but only if it is performed in a way that lets the fetus die rather than kills it is a possible position, we argue, first, that it is Blackshaw’s position that is inconsistent, second, that since deontology sees permissibility of a given result as path-dependent, deontologically oriented abortion ban advocates should find the view in question appealing rather than absurd and, third, that although there are indeed scenarios in which withdrawing life support is morally equivalent to killing, extraction abortions in the case of rape are not amongst them. Since in the case of rape the fetus is not entitled to life support, extraction abortions are better classified as permissible non-omissive allowings than impermissible killings. Thus, there is nothing absurd in the view that abortion in the case of rape is permissible but only if it is performed in a certain way. Accordingly, adopting this view does not seem to be much of a concession for abortion ban advocates who can therefore make an exception for rape.
Recent Updates on the Pathogenesis of Inflammatory Myopathies
Authors: Musai Jon , Mammen Andrew L. , Pinal-Fernandez Iago
Published: September 2024

Purpose of Review

This review aims to provide a comprehensive and updated overview of autoimmune myopathies, with a special focus on the latest advancements in understanding the role of autoantibodies. We will begin by examining the risk factors and triggers associated with myositis. Next, we will delve into recent research on how autoantibodies contribute to disease pathogenesis. Finally, we will explore the latest innovations in treatment strategies and their implications for our understanding of myositis pathogenesis.

Recent Findings

Recent research has revealed that myositis-specific autoantibodies can infiltrate muscle cells and disrupt the function of their target autoantigens, playing a crucial role in disease pathogenesis. Significant advances in treatment include CD19 CAR-T cell therapy, JAK-STAT inhibitors, and novel strategies targeting the type 1 interferon pathway in dermatomyositis. Additionally, the ineffectiveness of complement inhibitors in treating immune-mediated necrotizing myositis has challenged established views on disease mechanisms.

Autoimmune myopathies are a collection of disorders significantly influenced by specific autoantibodies that drive disease pathogenesis. This review highlights the critical role of autoantibody research in deepening our understanding of these conditions and discusses recent therapeutic advancements targeting key pathogenic pathways.
Predictive Hypoxemic Threshold for Tolerating the Apnea Test While Assessing Death by Neurological Criteria
Authors: Aviram Daniel , Hikri Daniel , Aharon Michal , Galoz Amir , Lichter Yael , Goder Noam , Nini Asaph , Adi Nimrod , Stavi Dekel
Published: September 2024

Background

The apnea test (AT) plays a vital role in diagnosing brain death by evaluating the absence of spontaneous respiratory activity. It entails disconnecting the patient from mechanical ventilation to raise the CO2 partial pressure and lower the pH. Occasionally, the AT is aborted because of safety concerns, such as hypoxemia and hemodynamic instability, to prevent worsening conditions. However, the exact oxygen partial pressure level needed before commencing AT, indicating an inability to tolerate the test, is still uncertain. This study seeks to determine pre-AT oxygen levels linked with a heightened risk of test failure.

Methods

We conducted a retrospective cohort study involving patients suspected of having brain death at the Tel Aviv Medical Center from 2010 to 2022. The primary outcome was defined as an arterial partial O2 pressure (PaO2) level of 60 mmHg or lower at the conclusion of the AT. This threshold is significant because it marks the point at which the saturation curve deflects, potentially leading to rapid deterioration in the patient’s oxygen saturation.

Results

Among the 70 patients who underwent AT, 7 patients met the primary diagnostic criteria. Patients with a PaO2 ≤ 60 mmHg at the conclusion of the AT exhibited a significantly lower initial median PaO2 of 243.7 mmHg compared with those with higher pre-AT PaO2 levels of 374.8 mmHg (interquartile range 104.65–307.00 and interquartile range 267.8–444.9 respectively, P value = 0.0041). Pre-AT PaO2 levels demonstrated good discriminatory ability for low PaO2 levels according to the receiver operating characteristic (ROC) curve, with an area under the curve of 0.76 (95% confidence interval 0.52–0.99).

Conclusions

PaO2 values at the conclusion of the AT are closely associated with PaO2 values at the beginning of the test. Establishing a cutoff value of approximately 300 mmHg PaO2 at the onset of AT may assist in avoiding saturation drops below 90%.
Analysis of genomic alternations in epidermal growth factor receptor (EGFR)-T790M-mutated non-small cell lung cancer (NSCLC) patients with acquired resistance to osimertinib therapy
Authors: Hsu Ping-Chih , Chang John Wen-Cheng , Chiu Li-Chung , Yang Cheng-Ta , Kuo Scott Chih‐Hsi , Fang Yueh-Fu , Wu Chiao-En
Published: September 2024

Background and objectives

Genomic alterations after resistance to osimertinib therapy in advanced T790M-mutated non-small cell lung cancer (NSCLC) are complex and poorly understood. In this study, we aimed to detect these genomic alternations via comprehensive next-generation sequencing (NGS) of tissue and liquid biopsies.

Patients and methods

From September 2020 to June 2021, 31 stage IIIB/IV T790M-mutated NSCLC patients who exhibited progressive disease after osimertinib therapy and provided written informed consent were recruited. Liquid and tissue biopsy samples for NGS testing were collected from 31 and 18 patients, respectively. Eighteen study patients had paired NGS data from tissue and liquid biopsies.

Results

With respect to the T790M mutation status, the preservation and loss rates were 33% and 67%, respectively, in both liquid and tissue biopsy samples. Five patients (16.1%) had the C797S mutation (4 liquid samples and 1 tissue sample). Two (6.5%) had MET mutations, 3 (9.7%) had BRAF-V600E mutations, and 1 (3.2%) had a KRAS-G12C mutation. Among the 18 patients who underwent tissue rebiopsies, those with preserved T790M mutation had significantly longer progression-free survival (PFS) with osimertinib therapy than those with T790M mutation loss (10.8 vs. 5.0 months, P = 0.045). Among all patients, those with T790M mutation loss in liquid biopsy samples had longer PFS after osimertinib therapy (10.8 vs. 7.5 months, P = 0.209) and postprogression survival (17.7 vs. 9.6 months, P = 0.132) than those with preserved T790M mutation based on liquid biopsies.

Conclusions

NGS using either tissue or liquid biopsy samples from advanced T790M-mutated NSCLC patients with acquired resistance to osimertinib therapy can detect various genomic alternations. Future studies focusing on subsequent tailored therapies on the basis of NGS results are warranted.
The Effect of a Mindfulness Course on Self-Compassion Among Occupational Therapy Students
Authors: Tal-Saban Miri , Biran Sigal , Fogel-Grinvald Haya , Golos Anat
Published: September 2024

Objectives

This study examined the impact of a mandatory course teaching mindfulness skills to first-year occupational therapy (OT) students' mindfulness skills and self-compassion. The objectives were to assess: (a) the correlations between students' mindfulness and self-compassion skills before and after participating in the course; and (b) the differences in mindfulness and self-compassion skills among the OT students who completed the mindfulness course.

Method

A cross-sectional, comparative, and correlation study design involved 106 first-year undergraduate OT students during three academic years, who participated in a mindfulness course. The students completed the Kentucky Inventory of Mindfulness Skills (KIMS) and the Self-Compassion Scale (SCS) before and after completing an academic semester.

Results

High and significant correlations were found between mindfulness skills and self-compassion total scores before versus. after completing the course. The post-scores of all the KIMS facets, besides “Acting”, were higher than the pre-scores; these differences were found to be significant for the total score, and for “Observing” and “Accepting” subscales. Significant improvement was also found in the SCS total score, and in all SCS components besides “Common Humanity”.

Conclusions

This study provides insights into the impact of a mandatory course teaching mindfulness and self-compassion skills to a large group of first-year undergraduate OT students. The results highlight the need to integrate mindfulness training into the curricula of health professions, such as OT. Practicing mindfulness and self-compassion may contribute to the personal and professional development of health profession students, as well as enhancing their ability to cope with academic pressures and challenges.

Preregistration

This study is not preregistered.
Dynamic Change Characteristics of Wetlands in Hefei and their Driving Factors Along the Urban–Rural Gradient
Authors: Zhang Hui , Li Chuntao , Zhang Yichen , Zhang Lang
Published: September 2024

Wetlands, as vital components of urban ecological infrastructure, provide essential ecosystem services. However, they face increasing risks of degradation and loss due to their vulnerability, environmental changes, and human activities. Therefore, effective restoration efforts are urgently needed. This study adopts a novel approach by considering the urban–rural gradient and integrates land use data, ecological parameters, and anthropogenic factors in Hefei City. Through morphological spatial pattern analysis, principal component analysis, and affinity propagation, this study identifies and analyzes urban–rural gradients. Using the optimal parameter geographic detector, the drivers of wetland changes from 1990 to 2020 are quantitatively assessed across different urban–rural gradients in Hefei. The findings indicate the following. (1) A persistent reduction in wetland expanse throughout the study duration, diminishing from 1274.56 km2 in 1990 to 1119.37 km2 in 2020, constituting a decrement of 12.17%. (2) Based on geographic detector outcomes, disparate driving forces underpin wetland dynamics across urban–rural gradients, with urban locales predominantly influenced by organic carbon and the proportion of impervious surface factors. Meanwhile, in agricultural and semi-ecological villages, silt is the primary factor, while ecological villages are primarily modulated by both silt and gross domestic product factors. Additionally, synergistic interactions manifest heightened explanatory power. This study elucidates the mechanistic underpinnings of wetland dynamics along urban–rural gradients, providing pivotal insights for developing targeted wetland restoration and conservation policies pertinent to the urban–rural developmental trajectory in Hefei City. Concurrently, it offers relevant recommendations for the multifaceted stewardship and sustainable development of wetlands in Hefei City in the foreseeable future.
Effective Treatment of Primary Orbital Squamous Cell Carcinoma with Radiotherapy: A Rare Case Report and Literature Review Update
Authors: Nath Jyotiman , Das Abhinandan , Saha Debasmita , Ahmed Shiraj , Kakati Kaberi , Dutta Anamika
Published: September 2024

Primary squamous cell carcinoma (SCC) of the orbit is exceptionally rare, comprising only a small fraction of ocular tumours, with most cases being secondary to tumours originating from nearby structures or due to distant metastasis. We present a case of primary orbital SCC in a 60-year-old male, discussing its diagnostic workup, imaging findings, and multidisciplinary management. The patient underwent definitive radiotherapy with concurrent chemotherapy after being deemed inoperable. Without any severe treatment-related adverse event, the patient achieved a complete metabolic response at 7 months post-treatment with maintained vision. As evident from a review of the literature, treatment approaches vary widely in this group of patients, with radiotherapy emerging as a successful modality in achieving disease control while preserving vision with acceptable toxicity. This case underscores the complexity of managing primary orbital SCCs and highlights the efficacy of radiotherapy in achieving favourable outcomes.
Gender differences in neurocognitive assessments: insights from a pilot study with the International Neurocognitive Test Profile (INCP) digital battery
Authors: Maierhofer Bernd , Grigoryeva Daria , Beck Beatrice , Lehrner Johann
Published: September 2024

Background

The aging global population has led to an increase in the number of dementia diagnoses, with projections indicating a continued upward trend. This demographic change presents profound challenges for patients, their families, and healthcare systems worldwide. Consequently, the demand for reliable and user-friendly screening tools that can detect dementia at early stages and monitor its progression is more critical than ever. The International Neurocognitive Test Profile (INCP), developed at the Medical University of Vienna, aims to address this need by offering a digital test battery for the early detection of dementia. This study forms a part of the INCP’s ongoing development and evaluation, specifically investigating the influence of gender on test outcomes.

Methods

Seventy participants, recruited through flyers at the Vienna General Hospital, completed the INCP assessment using tablets as part of the study. The effect of gender on performance across various INCP subtests was analyzed using Mann–Whitney U tests. For further exploratory analysis, a correlation matrix was calculated encompassing demographic variables (age and education), screening data, and all INCP subtests.

Results

The analysis revealed significant gender differences in two INCP subtests related to executive functions. Males outperformed females on the Figure Fluency Test (r = 0.30, indicating a moderate effect) and the Dice 2‑n Back Test (r = 0.29, indicating a small effect). However, when correcting for multiple comparisons, no significant gender disparities were observed in the scores of the subtests.

Conclusion

The identification of possible gender differences in specific subtests underscores the importance of considering gender as a variable in the further development and evaluation of the INCP. These findings offer valuable insights for the design and planning of future studies involving the INCP.
Marine eukaryote bioluminescence: a review of species and their functional biology
Authors: Duchatelet Laurent , Dupont Sam
Published: September 2024

Bioluminescence, the ability of organisms to produce visible light, has intrigued scientists for centuries. Studies have examined bioluminescence, using a wide range of approaches and organisms, from its ecological role to its underlying molecular mechanisms, leading to various applications and even a Nobel prize. Over the last ten years, an increasing amount of data has been collected leading to a growing number of recognized marine bioluminescent species. This review provides and describes a referenced listing of the eukaryotic luminous marine species, including information related to: (i) intrinsic versus extrinsic source of the bioluminescence, (ii) the color and maximum wavelength of emission, (iii) the bioluminescent system (substrate and enzyme) and the associated molecules, (iv) the availability of light organ/cell(s) pattern and histological structure, (v) the physiological control of the light production, and (vi) the demonstrated or suggested bioluminescent function(s). This listing provides basic information and references for researchers in or entering in the field of marine bioluminescence. Using a semi-quantitative approach, we then highlight major research gaps and opportunities and reflect on the future of the field.
Power of economics without power in economics?
Authors: Rath Johanna , Hornykewycz Anna , Burnazoglu Merve
Published: September 2024

Power relations dominate most social and economic processes. Despite its significance, however, the concept of structural power relations is often neglected in standard economics. Standard economics often confines itself to dissecting an idealised, abstract world, wherein power dynamics are abstracted from and seen as somewhat outside the economic realm. But, can economics be powerful in understanding, explaining and, ideally, tackling the multiple crises of our time without embedding the concept of power in its analysis? We suggest that the lack of consideration or insufficient engagement with power-related aspects in mostly standard approaches has far-reaching implications, as policies that neglect underlying power relations are not fit to address the crisis. This collection reopens the discussion of power in economics. Building on the talks and discussions at the 2023 EAEPE Pre-Conference that was held in Leeds, UK, this collection provides scholars an outlet to shed light on power structures within their field of research to highlight the complexity and interrelation of power and economics. We also conduct a literature analysis to identify different forms and categories of power used in the mainstream and heterodox economics literature with a particular focus on the different definitions and interpretations of the concept. We get our sample from the Web of Science (WoS) category ‘Economics’ in the WoS SSCI database, from 2010 to 2024. This approach provides a roadmap to better understand the different interpretations, definitions and conceptualisations of power within current literature.
Navigating affective and sensory fluidity in plurilingual and intercultural pedagogies in English language and literacy classrooms
Authors: Nigar Nashid , Kostogriz Alex
Published: September 2024

This article examines the transformation of Australian EAL/D (English as an additional language/dialect) classrooms, transitioning from a monolingual focus on Standard Australian English (SAE) to embracing plurilingual and intercultural approaches in English language and literacy teaching and learning. Employing hermeneutic phenomenological and narrative analyses, the study reflects on the lived experiences of 16 English teachers who learned English as an additional language and migrated to Australia. The research highlights the significance of fluid affective processes, cultural responsiveness, plurilingualism, and intercultural identity development in language and literacy classrooms. Findings emphasise the central role of affect in EAL teaching and its implications for cultural responsiveness and linguistic diversity. The lived experiences of these teachers underscore the transformative potential of diverse teaching strategies that resonate with students on affective and cultural levels. Implications include fostering plurilingual literacy and identity development, promoting global identity, and cultivating intercultural capabilities among learners and educators. Ultimately, the article highlights the paradigm-shifting power of English language and literacy education when enriched with empathy, creativity, and a commitment to linguistic and cultural diversity. This approach not only enhances EAL/D education but also offers valuable insights and implications for other areas of the curriculum and pedagogical practices, promoting a more inclusive and responsive educational environment across disciplines.
Party building in non-state sectors: a comparative study of China and Vietnam
Authors: Xiao Bin , Vu Quynh Phuong
Published: September 2024

With the advancement of the reform and opening up, the non-state Sectors (NSS) in China and Vietnam have developed rapidly. The ruling parties, which used to have comprehensive control over politics, economy, and society, have now found it difficult to control the new economic space. To effectively control NSS, the Communist Party of China and the Communist Party of Vietnam have attempted to embed themselves in NSS by expanding grassroots party organizations. In this process, they have adopted different strategies and procedures, resulting in two distinct models: China’s expansion model, which is characterized by a proactive approach combining rigidity and flexibility, and Vietnam's expansion model, which is characterized by a flexible approach with a focus on soft cooperation. This study compares the formation, nature, and main characteristics of the two models for party organization expansion in China and Vietnam, hoping to provide a more comprehensive and objective understanding of the developments in China and Vietnam, preliminarily elucidate, from an academic perspective, the operational model of party-building in NSS in the two countries, and enrich the theoretical research on the continuous expansion of the existing Leninist parties in the new era.
A novel stochastic matheuristic approach for the dynamic utilisation of arrival route structures: modelling of Istanbul Airport point merge system
Authors: Dönmez K. , Tükenmez İ. , Cecen R.K.
Published: September 2024

Congested airports benefit from parallel-point merge systems (P-PMSs) for efficient arrival route control. However, the decline in air traffic due to COVID-19 has curtailed its optimal utilisation, especially with the reduced need for long sequencing legs. As air traffic is poised to rebound, the evident volatility seen during and post COVID-19, as well as the daily fluctuations between peak and off-peak hours, underscore the importance of the dynamic utilisation of sequencing legs in P-PMSs. EUROCONTROL proposes various leg configurations to manage fluctuating traffics, ensuring both efficiency and safety. First, we proposed two additional leg configurations for the Istanbul Airport, offering continuous descent with the engines operating at idle thrust during leg flights; partially overlapped and fully dissociated. While they offer an alternative for controllers during low to medium traffic scenarios, current long and fully overlapped parallel legs may be used in high traffic due to the volatility of traffic density throughout a day. Therefore, we suggest an approach that provides dynamic utilisation of these configurations. We first modeled and analysed the configurations for various traffic numbers and scenarios. Then, we introduced a new stochastic matheuristic model that considers the configuration changes throughout the day and provides feasible and robust sequences applicable to all configurations by combining the benefits of mathematical models with the adaptability and speed of heuristic methods. Several test problems were evaluated using the terminal manoeuvering area structure of Istanbul Airport as a case study. The results indicate that by changing configurations, an average of 35 kg in fuel savings per aircraft can be achieved. The results also show that the proposed approach outperforms traditional stochastic mathematical models and the first-come first-serve (FCFS) strategy, ensuring efficient air traffic management in terms of fuel and delay with robust sequencing by eliminating the need for re-sequencing during configuration changes.
Incubation period of Clostridioides difficile infection in hospitalized patients and long-term care facility residents: a prospective cohort study
Authors: Curry Scott R. , Hecker Michelle T. , O’Hagan Justin , Kutty Preeta K. , Ng-Wong Yilen K. , Cadnum Jennifer L. , Alhmidi Heba , Gonzalez-Orta Melany I. , Saldana Carlos , Wilson Brigid M. , Donskey Curtis J.
Published: September 2024

Background:

The incubation period for Clostridioides difficile infection (CDI) is generally considered to be less than 1 week, but some recent studies suggest that prolonged carriage prior to disease onset may be common.

Objective:

To estimate the incubation period for patients developing CDI after initial negative cultures.

Methods:

In 3 tertiary care medical centers, we conducted a cohort study to identify hospitalized patients and long-term care facility residents with negative initial cultures for C. difficile followed by a diagnosis of CDI with or without prior detection of carriage. Cases were classified as healthcare facility-onset, community-onset, healthcare facility-associated, or community-associated and were further classified as probable, possible, or unlikely CDI. A parametric accelerated failure time model was used to estimate the distribution of the incubation period.

Results:

Of 4,179 patients with negative enrollment cultures and no prior CDI diagnosis within 56 days, 107 (2.6%) were diagnosed as having CDI, including 19 (17.8%) with and 88 (82.2%) without prior detection of carriage. When the data were censored to only include participants with negative cultures collected within 14 days, the estimated median incubation period was 6 days with 25% and 75% of estimated incubation periods occurring within 3 and 12 days, respectively. The observed estimated incubation period did not differ significantly for patients classified as probable, possible, or unlikely CDI.

Conclusion:

Our findings are consistent with the previous studies that suggested the incubation period for CDI is typically less than 1 week and is less than 2 weeks in most cases.