bluuebunny/crossref_metadata_2025 huggingface dataset:
Treatment of lymphoid malignancies in patients with primary immunodeficiencies associated with DNA repair defects
Authors: Anderzhanova L. Kh. , Rodina Yu. A. , Mukhina A. A. , Abugova Yu. G. , Abramov D. S. , Aleksenko M. Yu. , Vavilova L. A. , Dyakonova Yu. Yu. , Evstratov D. A. , Raykina E. V. , Fominykh V. V. , Shcherbina A. Y. , Deripapa E. V. , Myakova N. V.
Published: March 2023

Nijmegen breakage syndrome (NBS) and ataxia-telangiectasia (AT; Louis–Bar syndrome) are primary immunodeficiencies (PID) associated with chromosome instability and DNA repair defects that predispose individuals to an increased risk of various malignancies. In our study, we retrospectively analyzed clinical characteristics and outcomes of 28 cancer cases in 14 patients with AT and 10 patients with NBS who had been treated at the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology between January 2007 and December 2022. The study was approved by the Independent Ethics Committee and the Scientific Council of the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology. The most common type of malignancy was mature B-cell non-Hodgkin lymphoma (B-NHL) (42%), with diffuse large B-cell lymphoma (DLBCL) accounting for 91% of all B-NHL cases. Other cases included T-cell acute lymphoblastic leukemia (ALL) (n = 3), B-cell ALL (n = 2), Hodgkin lymphoma (n = 3), NK/T-cell lymphoma (n = 1), T-cell lymphoblastic lymphoma (n = 1), peripheral T- cell lymphoma (n = 2), medulloblastoma (n = 1) epithelioid rhabdomyosarcoma (n = 1), T-cell prolymphocytic leukemia (n = 2). A total of 4 patients were diagnosed with second malignancies (2 children with AT and 2 children with NBS. The diagnosis of PID was suspected or confirmed before the initiation of cancer therapy in 62% of AT patients and in 100% of NBS patients. Treatment was given in accordance with standard protocols with chemotherapy dose modifications. A total of 93% of patients with AT and 80% of patients with NBS required dose reduction. The level of response was quite high: 81% of patients with AT and 58% of patients with NBS achieved complete remission. According to our data, the use of reduced-dose chemotherapy regimens helps to achieve an acceptable toxicity profile without reducing the overall effectiveness of treatment.
Water beetles (Coleoptera: Haliplidae, Dytiscidae, Helophoridae, Hydrophilidae, Hydraenidae, Elmidae, Psephenidae, Scirtidae) of the Slavíč river basin, Czech Republic
Authors: Straka Michal , Kroča Jiří
Published: March 2023

Twenty-three sites within the Slavíč river basin (Silesia, Czech Republic) were surveyed to obtain up-to-date information on water beetles in the area. In total, 46 species comprising eight families were recorded. Significant findings included Ochthebius melanescens Dalla Torre, 1877, Hydrocyphon deflexicollis (Müller, 1821) (both endangered), Hydraena morio Kiesenwetter, 1849, Eubria palustris (Germar, 1818) (both vulnerable), Hydraena minutissima Stephens, 1829 (near threatened) and Elodes pseudominutus Klausnitzer, 1971 (data deficient). The Slavíč water beetle assemblage consisted mainly of typical rheophilic species, many characteristic for cold, mountainous waters, the most common beetles recorded being representatives of the families Elmidae and Hydraenidae. The species spectrum was significantly enriched by species found in non-riverine habitats along the Slavíč River floodplain (e.g. springs, wetlands and ponds), with representatives of the families Dytiscidae, Haliplidae and Hydrophilidae dominating.
Subfamily Phlebotominae (Psychodidae, Diptera) of the United Arab Emirates – some new faunistic data
Authors: Ježek Jan , Tkoč Michal , Oboňa Jozef , Manko Peter , van Harten Antonius
Published: March 2023

Biting midges (Phlebotominae) are medically important vectors of human and veterinary disease-causing agents. This study presents the results of the field research of arthropods of A. van Harten in the United Arab Emirates (UAE) during the period of approximately 2005 – 2007 at a high number of localities (15 are mentioned here, with 9 species collected incl. five confirmed; 4 spp. are new for the fauna of the UAE: Phlebotomus (Phlebotomus) papatasi (Scopoli, 1786), Sergentomyia (Parrotomyia) baghdadis (Adler & Theodor, 1929), S. (Sergentomyia) schwetzi Adler, Theodor & Parrot, 1929, S. (Grassomyia) squamipleuris Newstead, 1912).
Institutions Strengthening the Position of the Injured Party of the Offence of Failure to Pay Alimony under Section 196 of the Czech Criminal Code and in Selected European Legal Regulations
Authors: Rabinská Ivana
Published: March 2023

The offence of failure to pay alimony under section 196 is one of the most frequent offences in the Czech Republic. Since the protected interest is the right to support and maintain and the most common is the duty of parents towards their children, it is a very serious illegal activity that significantly endangers children and has a negative impact on their development, both health and social. In recent years, Czech legislators have focused on this issue and adopted institutes that strengthen the position of the injured party in these cases. Any kind of sanction has proved to be an ineffective tool for enforcing the delinquent alimony, so it has been necessary to ensure that it can be enforced by other means. Therefore, the legislators broadened the definition of the injured party in criminal proceedings and introduced the so-called substitute alimony. It is also interesting to look into foreign legal regulations and compare selected institutes.
Neutrophil-to-Lymphocyte Ratio and Systemic Inflammation Index as Predictors of Poor Outcome in Patients with Critical Limb Ischemia Treated with Remote Endarterectomy
Authors: Derșidan Anca Alexandra , Ciucanu Claudiu Constantin , Ilioniu Agatha Maria , Bodiu Ionela Georgiana , Covalcic Carina Diana , Szanto Ludovic Alexandru , Mureșan Adrian Vasile
Published: March 2023

Introduction: Severe ischemia occurring in the lower limbs represents the advanced stage of peripheral artery disease (PAD). Atherosclerosis and inflammatory markers have been intensively studied to identify prognostic tools with a role in the evolution of patients with PAD. The aim of this study is to demonstrate the predictive value of systemic inflammatory markers such as the neutrophil-to-lymphocyte ratio (NLR) and the systemic inflammation index (SII) in the prognosis of patients diagnosed with critical leg ischemia (CLI) undergoing infrainguinal surgical revascularization with remote endarterectomy.

Materials and methods: This retrospective study included all patients admitted to the Vascular Surgery Clinic of the County Emergency Clinical Hospital of Târgu Mureș, Romania between January 2018 and December 2021, who had critical limb ischemia Leriche-Fontaine stage III and were treated with endarterectomy. Patients were divided into two groups based on the presence or absence of patency in the lower limbs at 12 months.

Results: There was a higher baseline value of neutrophil count (p <0.0001), platelet count (p = 0.006), NLR and SII value (p <0.0001), as well as a lower value of lymphocyte count (p = 0.001) in the group without patency at 12 months. The ROC curve analysis showed that the NLR and SII were associated with the risk of major amputation and primary patency failure at 12 months, while multivariate analysis has shown that arterial hypertension (OR 3.63, p = 0.04), history of myocardial infarction (OR 2.93, p = 0.009), diabetes mellitus (OR 2.20; p = 0.04) and smoking (OR 3.48, p <0.0001) were also predictors of primary patency failure.

Conclusions: The results of this study demonstrated the predictive role of NLR and SII regarding poor outcomes among patients with CLI Leriche-Fontaine stage III undergoing infrainguinal surgical revascularization with remote endarterectomy.
A Linguistic Analysis Study for Teaching American-English Pronunciation: A Case Study Research
Authors: Vural Ersen , Hancı-Azizoglu Eda Başak
Published: March 2023

This linguistic case study research investigates the process stages of a language learner’s pronunciation errors through speech analysis detection techniques. The purpose of this study is to detect and analyze the pronunciation errors for internalizing the unique and individual pronunciation error patterns that vary from one individual to the next. A speech analysis technique, a method of applied linguistics, is used in combination with the case study method reveals a thorough evaluation map for the language learner’s pronunciation error characteristics. In this case study, the participant of the study is a native Chinese speaker. Within the scope of this research study, both the theoretical literature review and the data collection process uncover that pronunciation, unlike other domains of language teaching areas, requires specific and individualized attention for effective teaching and learning strategies. The data collected in this research study is analyzed in terms of phonetic linguistic features, and a personalized pronunciation improvement plan is proposed based on the linguistic features and characteristics of the research participant’s errors. A larger scale research study can be conducted for future research by verifying the findings of this research study with more language-specific research participants in order to develop individualized and learning-style focused pronunciation lesson plans for larger learning groups.
Implementing Design Thinking and Peer Instruction in an Online Environment to Develop Tourism Undergraduates’ English Language Skills
Authors: Sándorová Zuzana , Beták Norbert
Published: March 2023

Design thinking (DT) and Peer Instruction (PI) are two different and seemingly distant methods. However, both rely on students’ active participation, cooperation and communication with each other. Due to these features, therefore, they have the potential to foster foreign language competences successfully. Nevertheless, what if they were employed in a purely online learning environment? Could they still bring the praised learning outcomes, such as better conceptual understanding, more effective problem-solving, communication and teamwork skills, and increased student engagement and creativity? The present study aims to answer the given question by giving insight into implementing the methods in English for Specific Purposes courses at Constantine, the Philosopher University in Nitra (Slovakia). The action research findings were juxtaposed to the interview and questionnaire results revealing 101 tourism undergraduates’ views. Despite some technical issues and the students’ mixed-language communication, both DT and PI proved to be almost as effective in a purely online environment as in the case of a traditional classroom in terms of developing foreign language competences and problem-solving skills, creative or critical thinking, as well as enhancing teamwork and motivation.
Assessment of two low-cost geological materials as adsorbents for arsenic
Authors:   Facultad de Ingeniería Civil, Universidad de Guanajuato, Guanajuato, México, Coreño-Alonso Oscar , González-Gómez Leticia Elena ,   Licenciatura en Ingeniería Ambiental, Universidad de Guanajuato, Guanajuato, México, Coreño-Alonso Juan ,   División de Ingenierías, Universidad de Guanajuato, Guanajuato, México
Published: March 2023

Two easily accessible local materials, kaolin, and sediments from the reservoir of a dam, were evaluated to compare their efficiencies as adsorbents for As. The kaolin sample was composed mainly by kaolinite and quartz, while the sediments contained illite, montmorrillonite and quartz. Also, iron, calcium and magnesium minerals were present as minor components. The adsorption experiments were performed using batch equilibrium techniques. The samples were chemically treated using piranha solution, and trimesic acid, to study their effects on the adsorption capacity. The piranha treatment seems to be a good alternative to improve the adsorption capacity of kaolin. However, the intact reservoir sediments showed higher efficiencies than the intact or treated kaolin. On the other hand, the initial uptake of trimesic acid showed only a slightly positive effect on the arsenic uptake of the reservoir sediments. Most of the arsenic adsorption seems to be due to the finest particles of the sediments, composed mainly of iron minerals, while the organic matter contributes scarcely to the arsenic uptake. The influences of pH, contact time, initial arsenic concentration, and chemical treatments were studied. Freundlich and Dubinin-Kaganer-Radushkevich isotherm models were used to evaluate the arsenic uptake capacity of the intact and trimesic acid treated reservoir sediments. Maximum arsenic adsorption was completed almost within five hours of reaction, reaching a measured sorption capacity of 137 mg/kg for the intact sediments, slightly lower than for the trimesic treated sediments.
Analysis on the Evolution of Precipitation and Runoff Characteristics in the East Pi River Basin, China
Authors:   State Key Laboratory of Simulation and Regulation of Water Cycle in River Basin, China Institute of Water Resources and Hydropower Research, Beijing, China / Key Laboratory for Geographical Process Analysis & Simulation of Hubei Province, School of Urban and Environmental Sciences, Central China Normal University, Wuhan, China, Nie Hanjiang , Shen Zhenqian ,   Guangzhou Water Science Research Institute, Guangzhou, China, Qin Tianling ,   State Key Laboratory of Simulation and Regulation of Water Cycle in River Basin, China Institute of Water Resources and Hydropower Research, Beijing, China, Gong Xinfeng ,   College of Water Conservancy Engineering, Zhengzhou University, Zhengzhou, China, Huang Yinghou ,   College of Hydrology and Water Resources, Hohai University, Nanjing, Jiangsu, China
Published: March 2023

The natural hydrologic cycle is greatly influenced by climate change. In particular, substantial spatiotemporal variations in precipitation can occur in some mountainous areas, and thus it is very important to identify hydrological processes in watershed with high resolution. To analyze the problem above, the Mann-Kendall test, the moving T-test, Sen’s slope estimator and Spearman rank correlation test combined with the spatial interpolation function of ArcGIS, are used to analyze and discuss the evolution of the spatiotemporal distribution characteristics of precipitation and Runoff in a typical small watershed of mountainous areas. The result is precipitation showed a downward trend from south to north and from high-altitude to low-altitude regions. And the difference mainly occurred in the western part of the basin. And the conclusions show the following: 1) An abrupt change in both precipitation and Runoff sequences occurred in 1991; 2) the extreme value of the precipitation trend shifted from the central region to the western region; 3) for the ratio of Runoff in the flood season to annual Runoff, the sequence showed a significant upward trend (95 % confidence level), indicating that the uneven distribution of Runoff has significantly increased since the 1960s.
Опыт консервации сырцовых памятников археологии в рамках создания археологического парка на примере городища Культобе
Authors: Фейзулаев Алим Л.
Published: March 2023

В статье изложены основополагающие принципы и подходы к проведению при содействии коллектива международных и региональных специалистов археологических исследований и консервационных работ на городище Культобе в 2019–2021 гг. в границах объекта всемирного наследия ЮНЕСКО «Мавзолей Ходжи Ахмеда Ясави» в г. Туркестан, Республика Казахстан. Кратко освещены основные вехи изучения памятника, предыстория и некоторые аспекты реализации проекта «Реставрация исторических объектов городища Культобе», нацеленного на организацию на городище археологического парка. Освещена логика принятых консервационных и реставрационных решений в отношении выявленных сырцовых конструкций, а также подведены некоторые предварительные итоги. Отдельное внимание уделено соответствию проведенных мероприятий применимым международным документам, разработанным при содействии ЮНЕСКО, ИКОМОС и ИККРОМ.
Некоторые проблемы информационного сопровождения археологического предмета на примере комплекса погребения 1101 Танкеевского могильника
Authors: Валеева Валентина Александровна
Published: March 2023

В ходе многолетних археологических раскопок на территории Танкеевского могильника был получена уникальная коллекция предметов, которая неоднократно становилась объектом исследований различной направленности: археологической, естественнонаучной, культурологической и др. В статье на примере комплекса погребения 1101 Танкеевского могильника описываются процессы, происходящие с информационным полем археологического предмета в результате его изучения и музейного бытования. Археологический предмет проходит этапы музеефикации (от его обнаружения и изъятия из археологического объекта до получения статуса музейного предмета), музейного хранения и использования. При этом накапливается определенный объем информации, который, будучи зафиксированным на различных носителях, формирует его информационное поле. Оно является переменной величиной, изменяющейся как в сторону увеличения (при выявлении и сохранении информации), так и в сторону уменьшения (в случае утраты информации). Поэтому извлечение, фиксация и сохранение информации о предмете в максимально полном объеме и качественном содержании является важнейшей задачей исследователей.
Трубицыно 5 – новый памятник мезолита-энеолита на Верхнем Дону
Authors: Бессуднов Александр Николаевич , Захарова Елена Юрьевна
Published: March 2023

В статье представлены результаты анализа артефактов, относящихся к эпохам от мезолита до энеолита, полученных в результате раскопок 2018, 2022 гг. многослойного поселения Трубицыно 5 в правобережье р. Дон (Елецкий район Липецкой области). В совокупности обнаружено 916 каменных артефактов. В индустрии памятника использовалось, в основном, характерное для верхнедонского региона сырье: цветной валунный кремень, кварцит, песчаник. Единичные находки изготовлены из неместного черного мелового кремня. Для коллекции характерна преимущественно отщеповая техника снятия заготовок, гораздо меньше – пластинчатая. Представлен полный цикл обработки камня, прослеживаются такие приемы как обивка, ретуширование, шлифование, изредка – резцовое скалывание. Основная часть находок представлена свидетельствами обработки исходного материала. Выявлены также изделия со вторичной обработкой (скребки, скрёбла, рубящие, скобели, резцы, наконечники, провёртки, комбинированные орудия). Керамическая серия включает 57 фрагментов с ромбо-ямочным, ямочным, ямочно-гребенчатым, гребенчатым, ямчатым орнаментом. Остеологическая коллекция насчитывает 65 экз., из которых до вида определен 1 экз. (тур европейский); 1 фрагмент предположительно является частью какого-то изделия.
Каменные индустрии неолита полупустынной зоны как культурные индикаторы
Authors: Выборнов Александр Алексеевич
Published: March 2023

Начиная с 50-х годов ХХ в., в отечественном неолитоведении ведущим признаком выделения культуры признавалась керамика. Каменной индустрии отводилась вспомогательная роль. Она, по мнению специалистов, во многом зависела от природных факторов. Кроме того, характеристики орудий труда были достаточно общими для населения различных регионов. Данная статья направлена на выявление возможностей каменной индустрии неолита Северного Прикаспия для выделения археологической культуры. С этой целью авторами проведено сравнение каменного инвентаря неолитических памятников Северного Прикаспия и памятников, изученных в аналогичной ландшафтной зоне Приаралья. Выбор этой темы исследования объясняется также тем, что предшествующие исследователи отмечали большое сходство индустрий двух регионов. Авторами статьи проведено сравнение синхронных памятников обоих регионов. В результате проведенной в работы удалось выявить ряд различий в технике первичного раскалывания неолитического населения Северного Прикаспия и Приаралья. Прослеживаются и отличия в номенклатуре орудий труда. Выявлена и специфика вторичной обработки при изготовлении североприкаспийских и кельтеминарских артефактов. Это позволяет сделать вывод о том, что каменные индустрии полупустынных территорий Северного Прикаспия и Приаралья могут служить такими же культурными маркерами в неолите, как и керамика.
Скорченные погребения грунтового могильника Максимовка I эпохи энеолита
Authors: Королев Аркадий Иванович , Шалапинин Антон Александрович
Published: March 2023

Представленные данные о погребениях второй обрядовой группы с костяками в положении сидя и полусидя получены в ходе раскопок на грунтовом могильнике Максимовка I в 2017–2022 гг. Могильник расположен в левобережье среднего течения р. Самара. Анализируются 16 погребений эпохи энеолита. Следы могильных ям встречаются редко. Погребенный помещался в яму с приподнятой верхней частью туловища и упором спиной и затылком о ее стенку. Зафиксирована ориентировка головы погребенных в восточном секторе. Руки были вытянуты вдоль тела кистями на коленях или опирались локтями о дно ямы и кистями в области живота. Ноги согнуты коленями вверх. Среди погребений второй группы присутствуют костяки с обожженными черепами. Они составляют четвертую часть второй группы. Присутствует окраска охрой. Половина погребений содержит инвентарь: подвеску, бисер и бусы из раковины, костяные и раковинные пронизки, резцы сурка, костяные и каменные подвески, бусины из камня и окаменелости, наконечники стрел, кремневые пластины и отщепы, скребки, костяные орудия, кольцо из цветного металла, абразивы, отбойник, кости зайца, кость рыбы. В засыпи могильных ям часто встречаются отдельные фрагменты керамики. Вторичные погребения представлены черепами и сложенными кучкой костями человека. Инвентарь одного из этих погребений совпадает с вещами, найденными в погребениях второй группы. Материалы погребений второй группы близки Мурзихинскому II могильнику. На основании радиоуглеродного датирования, для погребений второй группы намечен широкий хронологический диапазон – 4400–3500 calBC, который позволяет их отнести к позднему энеолиту лесостепного Поволжья.
Находки джучидских монет XIII–XIV вв. в Пермском крае
Authors: Бугарчев Алексей Игоревич , Крыласова Наталья Борисовна
Published: March 2023

В работе рассматриваются контакты Волжской Булгарии с территорией Пермского Приуралья, в первую очередь, по нумизматическим данным. Авторы указывают, что в XI–XIV вв. торговый путь по реке Каме привёл к образованию факторий и городков, служивших перевалочными пунктами для булгарских и «чулыманских» купцов. Торговля осуществлялась посредством джучидских монет. Приводятся сведения о находках, опубликованных в XX в. Кроме этого, вводятся в научный оборот нумизматические материалы, найденные в XXI в., общим числом 9 экземпляров. Это три серебряные и шесть медных монет, чеканенные в середине – второй половине XIII в. Восемь из них выпущены на монетных дворах Булгарского региона, один дирхам отнесён к сарайской чеканке. Среди мест находок указываются Рождественское городище и город Соликамск.
Значение и функции бога Хонсу в «текстах пирамид» и «текстах саркофагов»
Authors: Дмитриева Юлия Вячеславовна
Published: March 2023

Несмотря на огромный научный интерес к мифологии и религии Древнего Египта, образ лунного бога Хонсу еще недостаточно хорошо изучен. Основной причиной этого является то, что до нас дошло очень мало источников, которые относятся к периоду Древнего и Среднего царства, а источники, относящиеся к более поздним периодам, наоборот имеются в большом количестве. Это привело к тому, что образ бога Хонсу более изучен в периоды своей наивысшей популярности в религии Древнего Египта, т.е. в период, начиная с эпохи Нового царства и до греко-римского времени. Первое упоминание о боге Хонсу встречается в «Текстах пирамид» – собрании заупокойных изречений, начертанных внутри пирамид царей V и VI династии с целью осуществления благополучия умершего фараона в загробном мире. С завершением Древнего царства религиозная литература претерпела значительные изменения. Начиная с VI-VII династий возникают религиозные тексты, высекаемые на поверхности саркофагов, которые получили название «Тексты саркофагов». Бог Хонсу упоминается в шестнадцати изречениях, выполняя различные, но взаимосвязанные друг с другом функции. Изучение ранних этапов формирования образа бога Хонсу поможет проследить эволюцию присущих ему функций и понять его роль в развитии древнеегипетской религии.
Pembinaan Parenting Education Berbasis Al Quran Di Lab School FIP UMJ
Authors: Bahar Herwina , Sundi Venni Herli , Hayattunnufus Hayattunnufus
Published: February 2023

ABSTRAKParenting education adalah suatu program yang dapat membuat orang tua dan guru di sekolah bisa bekerja sama. Program parenting sangat penting dilaksanakan karena menunjang proses pembelajaran peserta didik di rumah, hal ini dikarenakan orang tua adalah pendidik pertama seorang anak. Pengabdian masyarakat ini bertujuan mengembangkan pendidikan orang tua tentang pentingnya parenting education terutama di masa pandemi covid 19 dimana orang tua menjadi pendamping anak-anaknya untuk belajar di rumah. Pembinaan parenting education berbasis Al Quran dapat memperkuat konsep dasar orang tua dan guru dalam merealisasikan tujuan pendidikan. Metode yang digunakan dalam pengabdian masyarakat adalah menggunakan seminar dalam bentuk webinar. Hasil responden menunjukkan 81% orang tua paham tentang parenting. 41%, dan 58% orang tua merasa hasil yang baik dengan program parenting education yang diterapkan. Sebanyak 56% orang tua memiliki persepsi yang sangat baik terhadap pelaksanaan qiroati. 57%, dan sebanyak 32% orang tua memiliki rasa puas terhadap pelaksanaan qiroati di Lab School FIP UMJ. 70% orang tua menilai baik perkembangan pendidikan qiroati terhadap pembelajaran di rumah. Sebanyak 93% orang tua yang memiliki pola pengasuhan demokratis di rumah. Sebanyak 96% pendampingan pembelajaran di rumah didampingi oleh orang tua. 79% orang tua merasa kesulitan dalam pendampingan pembelajaran anak di rumah adalah konsentrasi anak. Di lab school FIP UMJ sebanyak 54% komunikasi orang tua dan guru berjalan dengan baik. 57% orang tua menyiapkan waktu khusus dalam proses pembelajaran di rumah. 78% pengasuhan positif yang dilaksanakan di rumah meliputi keteladanan orang tua, komunikasi efektif dan memperkuat dan memperbanyak ibadah. Kendala yang sering dihadapi adalah kesibukan orang tua. Kata kunci: Parenting Education, Al Quran
PERANCANGAN ULANG TATA LETAK FASILITAS PRODUKSI UKM EKO BUBUT DENGAN METODE COMPUTERIZED RELATIONSHIP LAYOUT PLANNING (CORELAP)
Authors: Adiyanto Okka , Clistia Anom Firda
Published: March 2023

Perancangan sebuah tata letak fasilitas produksi merupakan salah satu hal yang penting untuk meningkatkan hasil produksi serta memperlancar alur proses produksi. Penelitian kali ini dilakukan di Usaha Kecil Menengah (UKM) Eko Bubut yang memproduksi kerajinan dari kayu. Kendala yang dihadapi UKM Eko bubut yaitu, banyaknya produk yang menumpuk di departemen jigsaw dan bubut. Selain adanya penumpukan produksi, penghambat aliran produksi yaitu adanya back tracking di departemen oven ke departemen pengecatan. Tujuan dari penelitian ini adalah untuk merancang layout usulan dengan metode CORELAP. Produk yang diambil untuk melakukan penelitian ini adalah sendok kayu yang memiliki 9 departemen. Penelitian ini menggunakan metode CORELAP merupakan metode construction yang mengubah data kualitatif menjadi data kuantitatif sehingga menentukan fasilitas pertama yang diletakkan didalam layout diperlukan data keterkaitan hubungan aktivitas. Terdapat 3 hasil alternatif menggunakan CORELAP, alternatif 1 memiliki OMH sebesar 13.410,96 dan skor sebesar 30. Alternatif 2 OMH sebesar 6.318,21 dan skor sebesar 31. Alternatif 3 memiliki OMH sebesar 5.304,59 dan skor 26. Dari hasil perhitungan CORELAP maka dipilih usulan alternatif 3.
PENGUKURAN KINERJA RANTAI PASOK MENGGUNAKAN SUPPLY CHAIN OPERATIONS REFERENCE (SCOR) DI UD. ANANDA
Authors: Sriwana Iphov Kumala , Hijrah S Nurul , Suwandi Arief , Rasjidin Roesfiansjah
Published: March 2023

Supply chain performance measurement has an important role to play in formulating a strategy in running a company's business. UD Ananda is a company engaged in the production and sale of wooden furniture. UD. Ananda has never done a performance measurement in the supply chain that runs at the company. The purpose of this study is to determine the performance value and achievement of each company performance indicator. Performance measurement using the Supply Chain Operations Reference (SCOR) model. This model includes a performance indicator / Key Performance Indicator (KPI) that has been validated using a questionnaire to then determine the weight of each performance indicator point using the Analytical Hierarchy Process (AHP) and normalizing the score with Snorm De Boer. The traffic light system method is used to display performance indicators that are far from the company's target and become a priority for improvement, namely 7 indicators out of 17 validated indicators. The results of supply chain performance measurement at UD. Ananda was 71.43 for June and 79.37 for July. This value indicates that the supply chain performance value in the company is in a position of good performance.
Strategi Persaingan Jamu Gunanty Menggunakan Matriks: Internal Eksternal, Bowman Strategy, Grand Strategy dan Profil Kompetitif
Authors: Nowira Puti Annisa , Sari Rianita Puspa
Published: March 2023

Jamu Gunanty memiliki pangsa pasar yang cukup luas, namun tidak menutup kemungkinan ada kompetitor yang bergerak dalam bidang yang sama. Keberhasilan perusahaan dalam persaingan yang semakin kompetitif tergantung pada keunggulan bersaingnya. Penelitian ini bertujuan untuk mengkaji faktor penentu keberhasilan, posisi bersaing, serta merumuskan alternatif strategi bersaing pada UMKM Jamu Gunanty. Analisis Strategi Persaingan menggunakan matriks Internal Factor Evaluation (IFE), External Factor Evaluation (EFE), Competitive Profile Matrix (CPM), Internal External (IE), Grand Stratagy dan analisis Bowman Strategy. Hasil penelitian menunjukkan bahwa nilai bobot matriks Internal Factor Evaluation (IFE) sebesar 2,75 (relatif sedang) dan External Factor Evaluation (EFE) 3,01 (posisi kuat). Pada matriks Internal External (IE) strategi yang harus dilakukan adalah growth and build. Pada matriks kompetitif Jamu Gunanty dengan menggunakan dua kompetitor berada pada posisi kedua atau tengah. Posisi bersaing berdasarkan matriks bowman strategy, Jamu Gunanty berada pada posisi hybrid (harga relatif murah, nilai produk standar).
La cadena del mercurio en la Monarquía Hispánica a partir de su historiografía
Authors: Laris Pardo Jorge Alejandro
Published: March 2023

El presente es un ensayo bibliográfico sobre el comercio hispano del mercurio en los siglos XVI a XVIII que propone un modelo del comercio del azogue a partir de la Metodología de las Cadenas de Mercancía. Se ha dividido la temática en cuatro secciones: el motor, la producción, el comercio y el consumo. Este orden sistematiza y sintetiza el conocimiento historiográfico. Deja en evidencia el alcance transcontinental de esta cadena de mercancía.
Phylogenetic Analysis of Chrysochamela (Fenzl) Boiss. (Brassicaceae) Taxa Growing in Turkey
Authors: Sevindik Emre , Paksoy Mehmet Yavuz , Topseçer Feyzanur , Aydoğan Melike
Published: March 2023

In this study, we performed a genetic diversity analysis using RAPD (Random Amplified Polymorphic DNA) and ISSR (Inter simple sequence repeat) markers for some Chrysochamela species growing in Turkey. PCR was performed using RAPD and ISSR primers and genomic DNA samples from each specimen, and the resulting bands were scored. Phylogenetic relationships and genetic distances between the studied taxa were calculated using the PAUP analysis program. According to the RAPD analysis, the closest genetic distance was found to be 0.20000 between C. noeana populations, while the most distant values were found as 0.60000 between C. noeana and C. elliptica. The ISSR analysis also revealed the closest genetic distance as 0.34043 between C. noeana populations, while the most distant values were found to be 0.55319 between C. noeana and C. elliptica. UPGMA (unweighted pair group method with arithmetic mean) dendrogram generated for both RAPD and ISSR analyses consisted of two groups. As a result, it was found that RAPD data were more appropriate for comparison with the previous anatomical and morphological data of the studied taxa.
Scavenging Effect, Chemical Composition and Antispasmodic Activity of the Essential Oil of Origanum Onites L.
Authors: Saygın Hüseyin , Saraç Bülent
Published: March 2023

Origanum onites L essential oil of antispasmodic activity, chemical composition and the radical scavenging were determined in vitro. GC-MS analysis that was been carried out upon the essential oil revealed 31 different composites which equal to 94.60% in which Carvacrol (49.01%), linalool (13.3%) were found as major components. Free radical scavenging capacities of the essential oil were measured by 2,2-diphenyl-1-pikrilhidrazil (DPPH) assay and via β-carotene linoleic acid experiment were determined. It showed IC50 value of Origanum onites essential oil was been identified as 430 mg/mL, the IC50 value for BHT was 19.8 mg/mL, the β-carotene linoleic acid assay also showed the 80% inhibition with the essential oil of Origanum onites.it showed very strong antioxidant activity. In addition, dose dependently (0.1, 0.5, 1.0 and 2 mg/mL) inhibits the contraction induced by, it was able to inhibit the rat ileum muscle by 2 mg/mL to 100%.
Milk Production and Composition in Camel and Its Beneficial Uses: A Review
Authors: Ali Wajid , Akyol Ethem , Ceyhan Ayhan , Dilawar Sadia , Firdous Asia , Qasim Muhammad Zia ul , Ahmad Muhammad Moiez
Published: March 2023

Globally, 16.9% of milk used by humans is taken from different species other than a cow. These species are sheep, horse, yak, ass, goat, camel and buffalo. The global camel (Camelus dromedarius) population is about 34 million head with sharing of almost 0.4% of world‘s non-cattle milk. Within the last 20 years, the curiosity of camel farming is amassed remarkably in different countries of the world including the Netherland, Italy and USA for camel milk production. The camel is considered as a goal animal of the 21st century because it produces high quality milk under extreme temperature, deficiency of pasture and dearth of water. The average milk production of camel fluctuates from 4 to 30 lt with lactation length ranges from 9 to18 months having peak yield in second to the third month of lactation. Camel‘s milk is used globally because of its salty taste, high vitamin C concentration and its medicinal properties. Nevertheless, it gives many valuable benefits such as treatment of autism, control diabetes and allergy, prevention from liver cirrhosis and replacer of cow milk to avoid an infant‘s allergic reaction. The camel milk is a natural treatment of diabetes as it has a substantial result in a decrease of mean blood glucose and conserves necessary insulin doses. Camel milk constitutes of protein (2.5-4.5%), fat (2.9-5.5%), solid not fat (8.9 -14.3%), ash (0.35-0.95%), lactose (2.9-5.8%) and water (86.3-88.5%) as mean specific gravity is 1.03. Due to its distinct properties, the consumption of camel milk is increasing day by day and a number of industries are working to promote camel milk production and processing. Therefore, the tenacity of this review article is to explicate the beneficial uses and production of camel milk over the globe.
Effects of Different Drying Methods on Modelling, Energy Consumption and Final Quality of Tomato (Lycopersicum esculentum Mill)
Authors: Polatcı Hakan , Erkmen Yücel
Published: March 2023

Agricultural developments mostly depend on rapidly increasing world population. Tomato is a highly nutritious vegetable. Post-harvest technologies are often applied to prolong the consumption periods of tomato. Drying is one of the oldest methods of conservation. In this study, five different drying methods (oven drying, vacuum oven drying, sensitive drying, shaded-open atmosphere drying and sun drying) was used. Drying processes were carried out with dryers at 55Â°C, 60Â°C, 65Â°C and 70Â°C temperatures. All drying trials were performed in three replications. Drying performance (drying duration, final moisture content), drying kinetics, colour analysis, energy consumption, chemical analyses were performed for all drying methods. Fresh samples reached to desired moisture contents in 20-300 hours. To define time-dependent changes in moisture contents, Page, Logarithmic and Midilli-Küçük equations were used. Page equation yielded the worst estimations. There were not significant differences in “a” redness values of fresh samples, 65-70ï‚°C of oven dryer and all temperatures of sensitive dryer. Sensitive dryer yielded the closet pH values to fresh samples. Based on current findings, it was concluded that oven drying, and sensitive drying were suitable for drying Selinus tomato variety.
Histomorphological Study on the Pyloric Caeca and Intestine of Black Sea Trout (Salmo labrax Pallas, 1814)
Authors: Özel Osman Tolga , Coskun Isa , Cakmak Eyüp , Cimagil Recayi
Published: March 2023

This study was conducted to determine about the histomorphology of anterior, middle and posterior intestines and pyloric caeca of fifth-generation Black Sea trout (Salmo labrax Pallas, 1814). The adult Black Sea trout were 29 month age and averagely weighted 1106.9±73.88g. Pyloric caeca and intestine tissue of twenty fish were taken in seawater. Intestine was divided into three sections: anterior, middle and posterior. Pyloric caeca and intestine had four layers from the inside to outside: mucosa, submucosa, muscularis and serosa. Muscularis was gradually decreased from the beginning of the anterior intestine to the end of the posterior intestine. While pyloric caeca had the lowest muscularis, anterior intestine had the highest muscularis. The highest villi length was obtained in middle 1, and also posterior intestine had two types of villi as simple and complex villi. Simple villi had lower villi length and fewer villi number. Complex villi, branched out along the intestine, contained a large of simple villi. As a result, the histomorphological structure of the midgut section of the adult Black Sea trout shown an alteration section by section.
The Effect of Drying Methods on Color and Chlorophyll Content of Parsley Leaves
Authors: Alibas Ilknur , Zia Mahrukh Parveez , Yilmaz Aslihan
Published: March 2023

Parsley leaves (Petroselinum crispum L.) weighing 100 ± 0.09 g were dehydrated from moisture content of 82.24 ± 0.07% to 10.01 ± 0.02 % (wet basis) using the microwave (MD), convective (CD), solar oven (SOD), sun (SD) and natural (ND) drying. Drying in MD, CD, SOD, SD, and ND was completed at 18±1.15, 61±0.58, 255±10, 330±5.29, and 1530±11.55 min, respectively. The energy consumption of MD and CD was measured as 0.213±0.009 and 0.427±0.015 kWh, respectively. In microwave drying, 700 W microwave output power was applied while convective drying was used with 50Â°C temperature and 1m/s air velocity. The sun and solar oven drying processes were carried out under the same conditions at the same time. The average temperature of the system during the solar oven drying was 81.7±1.5Â°C whereas the airflow in the system was 0.5 m/s. The data obtained from the experiments were also modeled using twelve different thin-layer drying equations, and thus the theoretical data were obtained. According to these theoretical data, the best model in the microwave and natural drying was Alibas‘s equation while the most suitable model in the solar and convective drying was modified Henderson and Pabis‘s model. On the other hand, it was seen that the best model in the solar oven drying was the Page equation. As a result, considering both quality and drying parameters, it was determined that MD and SOD were the most suitable method for drying of parsley leaves.
Wild Edible Mushroom Cantharellus cibarius as a Natural Antioxidant Food
Authors: Sevindik Mustafa
Published: March 2023

In this study, DPPH free radical activity, total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) of wild edible mushroom Cantharellus cibarius Fr. collected from Antalya (Turkey) province were determined. Ethanol (EtOH), methanol (MeOH) and dichloromethane (DCM) extracts of C. cibarius mushroom were obtained using soxhlet apparatus. TAS, TOS and OSI values were determined by using Rel Assay kits. Free radical scavenging activity was determined using DPPH method. As a result of the studies, TAS value of the mushroom was found as 5.268±0.059 mmol/L, TOS value was 6.380±0.256 Î¼mol/L and OSI value was 0.121±0.005. DPPH free radical activity was determined as EtOH extract 70.52±0.50, MeOH extract 64.34±1.54 and DCM extract 61.72±0.59 in 1 mg/mL extract concentration of mushroom. As a result, edible C. cibarius mushroom could be a natural antioxidant source.
Bitkisel Kaynaklı Yenilebilir Film ve Kaplamaların Minimal İşlem Görmüş Meyve ve Sebzelere Uygulanması
Authors: Kozlu Ali , Elmacı Yeşim
Published: March 2023

Günümüz tüketicileri değişen yaşam tarzı ile birlikte besin değeri yüksek, fonksiyonel özellikleri iyileştirilmiş ve raf ömrü uzun gıdalara yönelmektedir. Minimal işlem görmüş taze meyve ve sebzelere olan ilgi sağlıklı, besleyici ve tüketime hazır olmaları nedeniyle artmaktadır. Ancak hasat sonrası devam eden solunum, terleme gibi biyolojik faaliyetler depolama boyunca meyve ve sebzelerde su ve çözünen madde kaybına yol açmakta, ortamdaki gaz konsantrasyonunu değiştirmekte, bu durum kütle kaybı, besin değeri ve raf ömrü gibi kritik kalite parametrelerini büyük ölçüde etkilemektedir. Parçalama, kesme veya kabuk soyma gibi küçük ölçekli işlemler meyve ve sebzelerin yüzey alanını arttırdığı için çeşitli enzimatik reaksiyonları tetiklemekte dolayısıyla raf ömrünü azaltmaktadır. Taze meyve ve sebzeye en yakın kalitede bir ürün üretmek, istenen kalite özelliklerini korumak, mikrobiyolojik bozulmaları kontrol altına almak ve raf ömrünü uzatmak amacıyla kullanılan inovatif yöntemler arasında doğal, çevre dostu, ekonomik ve kolay uygulanabilir olması nedeniyle ‘‘yenilebilir film ve kaplamalar” ön plana çıkmaktadır. Ayrıca minimal işlenmiş meyve ve sebzelere uygulanan bu tip kaplamaların formülasyonlarında bitkisel kaynaklı materyallerin de kullanılması tüketicilerin ilgisini çekmekte ve ürünlere olan güveni arttırmaktadır. Bu derlemede, sürekli artan tüketici taleplerini karşılayacak yeni bir gıda ambalajlama yöntemi olan bitkisel kaynaklı yenilebilir film kaplamaların minimal işlem görmüş taze meyve ve sebzelere uygulanması ve depolama süresince ürünlerde meydana gelen bazı fiziksel, kimyasal, duyusal ve mikrobiyal değişimlere olan etkisi hakkında bilgi verilmiştir.
Meriç Nehri (Türkiye) Teraslarında Oluşan Toprakların Bazı Profil ve Verimlilik Özelliklerinin Belirlenmesi
Authors: Yüksel Orhan , Ekinci Hüseyin
Published: March 2023

Bu çalışma, Meriç Nehri‘ne farklı uzaklık ve yükseklikte yer alan alüviyal teraslar üzerinde oluşmuş toprakların bazı profil ve verimlilik özelliklerini incelemek amacıyla yapılmıştır. Meriç nehrine dikey konumda ve farklı uzaklıklarda yer alan dört farklı noktada açılan toprak profillerinin horizon tanımlaması yapılmıştır. Söz konusu profillerden 28 adet bozulmuş toprak örneği alınarak bu örneklerde bazı fiziksel ve kimyasal analizler yapılmıştır. Profil 1 (P1), profil 3 (P3) ve profil 4 (P4)‘ün bulunduğu arazilerde çeltik tarımı yapılırken, profil 2 (P2) çok uzun süreden beri mera olarak kullanılan bir arazi üzerinde incelenmiştir. Araştırma topraklarının organik madde içerikleri genel olarak “az” ve “çok az” olarak bulunmuştur. En yüksek organik madde değeri P2 de A1 horizonunda (%3,22) ve profil 4 de Ap horizonunda (%2,09)‘dır. Toprakların pH değerleri genel olarak “hafif asit” ve “nötr” karakterde olup kireç içerikleri P2 de “kireçli”, diğer profillerde “az kireçli” sınıfındadır. Araştırma örneklerinde P2‘de tuzluluk sorununa rastlanmıştır. Bu profilde horizonların EC değeri A1 horizonunda 6,51 dS m-1 olarak bulunmuştur. Aynı şekilde bu horizonda Na içerikleri de çok yüksek bulunmuştur. P2, topoğrafik olarak diğer profillere göre daha çukur bir konumda olup yılın önemli bölümünde su altında kalmaktadır. Bu nedenle P2 genellikle yaş olup redoksimorfik özelliklere, yüksek kil içeriğine ve buna bağlı olarak fena drenaj koşullarına sahiptir. P1, nehire en yakın konumda olup kum içeriği diğer profillere göre yüksektir. Katyon değiştirme kapasitesi (KDK) kil içeriğine bağlı olarak profil 2 de en yüksek, P1 de ise en düşüktür. Profillerde yarayışlı besin elementi içerikleri alt katmanlara doğru azalma göstermekle birlikte profillerin üst katmanlarında fosfor (P), demir (Fe), bakır (Cu), mangan (Mn) ve çinko (Zn) içerikleri “yeterli” bazılarında “fazla” düzeydedir. Buna karşın potasyum (K) içeriği sadece P2 de “yeterli”, diğer horizonlarda “az” düzeyde bulunmuştur.
The effects of Isatis tinctoria extract on diseases resistance against Aeromonas hydrophila and pigmentation, growth of Pseudotropheus acei
Authors: Bıyıklı Muhammed , Bahadır Koca Seval , Özgür Yiğit Nalan , Metin Seçil , Kara Nimet , Gürbüzer Gökhan
Published: March 2023

This study was conducted with aim to investigate the effects of Isatis tinctoria leaves extract on growth performance, pigmentation and protection against Aeromonas hydrophila of Pseudotropheus acei. Five diets were prepared by adding four different ratios fish woad extraction (Woad: W1: 1%, W1.5: 1.5 %, W2: 2 %, W2.5: 2.5% and C: control diet 0 %). Three replicates were conducted for each treatment. One hundred twenty fish and 15 tanks (80 x 30 x 80 cm) were used in recirculating system. In the end of 90 days, there were no differences in terms of weight gain, FCR and SGR of Pseudotropheus acei feed with diets added with different levels of Isatis tinctoria extraction compare to control group. Isatis tinctoria extract was not found effect on survival rates in Pseudotropheus acei after A. hydrophila infection. However, there were no differences on pigmentation of Pseudotropheus acei. Isatis tinctoria extract administration did not provide protection against Aeromonas hydrophila infection.
Aspir (Carthamus tinctorius L.)‘de Uygun Çimlenme Sıcaklığının Belirlenmesi Üzerine Bir Araştırma
Authors: Kurt Orhan , Şenel Alper Anıl , El Bey Naziha , Göre Merve
Published: March 2023

Bu araştırma, Ondokuz Mayıs Üniversitesi, Ziraat Fakültesi, Tarla Bitkileri Bölümünde, laboratuvar koşullarında yürütülmüştür. Araştırmada materyal olarak Balcı ve Dinçer olmak üzere iki aspir çeşidi kullanılmıştır. Araştırmada çimlenme sıcaklığı olarak 8, 12, 16, 20, 24, 28, 32 ve 36 Â°C olmak üzere, 4Â°C derece aralıklı olacak şekilde, toplam 8 farklı sıcaklık uygulamıştır. Araştırma sonuçlarına göre, her iki çeşitte de çimlenme oranının uygulanan çimlenme sıcaklıklarından istatistiki anlamda çok önemli düzeyde etkilenmiş olduğu, genel ortalama çimlenme oranının %56,1 olduğu belirlenmiştir. Çeşitlerin çimlenme oranı Balcı çeşidinde %58,7 ve Dinçer çeşidinde %53,6 olduğu belirlenmiştir. Çimlenme sıcaklıklarına göre aspirde çimlenme oranının %35,3 ile %71,7 arasında değiştiği, en yüksek çimlenme oranının 16Â°C sıcaklıkta elde edildiği belirlenmiştir. Çeşit x çimlenme sıcaklığı interaksiyonu bakımından değerlendirildiğinde en yüksek çimlenme oranının %76,2 ile Balcı çeşidinden 16Â°C çimlenme sıcaklığında elde edilmiştir. Ayrıca çimlenme sıcaklığı ile çimlenme oranı arasındaki ilişkiler de çok önemli olduğu belirlenmiştir. Sonuç olarak çimlenme sıcaklığının 16Â°C‘ye kadar arttığında, çimlenme oranının da arttığı ve 16Â°C‘den daha yüksek çimlenme sıcaklıklarda ise çimlenme oranının azaldığı belirlenmiştir.