bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimization of polysaccharides extracted from Verbena officinalis L and their inhibitory effects on invasion and metastasis of colorectal cancer cells
Authors: Jin Chao-chao , Liu Xian-mei , Ma Dan , Hua Xian-liang , Jin Nuo
Published: March 2021

Purpose: To investigate polysaccharides (PEV) extracted from the aerial part of Verbena officinalis L. and their inhibitory effects on the invasion and metastasis of colorectal cancer (CRC) cells.Methods: PEV was extracted by water and the optimization of extraction conditions was performed using a Box-Benhnken design (BBD). The cell viability was evaluated by 4,5-dimethylthiazol-2-yl)2,5-diphenyltetrazolium bromide (MTT) assay. The effects of PEV on cell adhesion and invasion were evaluated by Transwell invasion, wound healing migration and adhesion assays in vitro. The effects of PEV on the expressions of matrix metalloproteinase-9 (MMP-9), mesenchymal-epithelial transition factor (C-met), E-cadherin (E-CAD), cyclooxygenase-2 (COX-2) and E-prostanoid 2 receptor (EP2) were investigated by western blot.Results: The BBD model was established successfully for the optimization of PEV extraction (p <0.0001). The results indicate that PEV (50, 100 and 200 μg/mL) had significant inhibitory effects on cell invasion and migration of SW480 cells (p < 0.05). PEV also significantly decreased cell adhesion of SW480 cells. By treating with PEV, the expressions of C-met, MMP-9, COX-2 and EP2 were decreased, whereas the expression of E-CAD increased in SW480 cells.Conclusion: RSM is effective for optimizing the extraction conditions of PEV. More importantly, PEV significantly inhibits the invasion and metastasis of SW480 cells by regulating the expression of MMP-9, C-met, E-CAD, COX-2 and EP2. Thus, PEV has the potential to be developed into therapeutic drugs for CRC in the future.Keywords: Polysaccharides, Colorectal cancer, Verbena officinalis, SW480 cell lines, Cell invasion, Metastasis
Effect of mebendazole on fibrosarcoma in hamsters
Authors: Popović Dušica J , Lalošević Dušan , Popović Kosta J. , Čapo Ivan , Popović Jovan K. , Miljković Dejan
Published: March 2021

Purpose: To investigate the effect of mebendazole on an in vivo solid tumor model of fibrosarcoma in hamsters.Methods: 24 Syrian golden hamsters of both sexes with the approximate body  weight of 100g were randomly distributed in 2 experimental and 2 control groups, with 6 animals in each group. BHK-21/C13 cells (2 x 106) in 1 mL Glasgow Minimum Essential Medium (GMEM) were injected subcutaneously into the back of each animal in 3 groups. The experimental groups were treated with mebendazole  (460 mg/kg) via a gastric tube on a daily basis, immediately after tumor inoculation. In addition, one experimental group received deoxycholic acid 20 mg/kg once a day. After 2 weeks, when the tumors were approximately 1 - 2 cm in the control group, all the animals were sacrificed, and their blood collected for laboratory analysis. The tumors were excised, their weight and diameters measured, and the volumes  calculated. The tumor samples were histopathologically assessed and the main organs toxicologically analyzed. Images were taken and processed by an imaging software, and Ki-67-positive cells in the tumor samples were quantified.Results: Mebendazole diminished tumor mitosis from 18.5 ± 3.02 to 13.5 ± 3.45 (p < 0.05), vasculature and tissue penetration, and increased necroses in tumor  slices. Tumor volume and weight were insignificantly attenuated. Toxicity was not observed.Conclusion: Mebendazole might be an effective non-toxic agent in sarcoma therapy.Keywords: Mebendazole, Hamsters, BHK-21/C13 cells, Fibrosarcoma therapy,  Tumor mitosis
Ethnomedicinal uses and pharmacological activities of Croton megalobotrys Mϋll Arg: A systematic review
Authors: Maroyi Alfred
Published: March 2021

Purpose: To provide an overview of the ethnomedicinal uses and pharmacological activities of Croton megalobotrys as to understand its potential value and  importance in primary health care systems of local communities throughout its distributional range.Methods: The literature search for information on ethnomedicinal uses and  pharmacological activities of C. megalobotrys was undertaken using databases such as Web of Science, BMC, Science Direct, Elsevier, Scopus, PubMed and Scielo. Other relevant literature sources included books, book chapters, websites, theses, conference papers and other scientific publications.Results: Croton megalobotrys is an important herbal medicine in southern Africa used as an abortifacient and purgative,and as remedy for human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) opportunistic infections, malaria, muscle aches or pain, sexually transmitted infections (STIs) and skin infections. The chemical constituent of C. megalobotrys is mainly composed of  alkaloids and cinnamate derivative isolated from the stem bark. The biological activities demonstrated include antibacterial, antiplasmodial, anti-HIV and radical scavenging activities.Conclusion: The historical traditional usage of C. megalobotrys as herbal medicine in southern Africa calls for detailed phytochemical and pharmacological properties of the species aimed at identifying the compounds responsible for its wide usage as an herbal medicine.Keywords: Alkaloids, Croton megalobotrys, Ethnopharmacology, Primary health, Southern Africa
Application of a widely-used tropical anti-worm agent, mebendazole, in modern oncology
Authors: Popović Dušica J , Poša Mihalj , Popović Kosta J , Kolarović Jovanka , Popović Jovan K. , Banović Pavle Z.
Published: March 2021

Although clinical trials have not been completed, it has already been confirmed that mebendazole, a well-known anti-parasitic drug widely used in the tropical areas, inhibits cancer cell growth. Preclinical studies show that mebendazole notably impedes the growth of malignant and metastatic tumors such as osteosarcoma and soft tissue sarcoma, melanoma, carcinoma (lung, colorectal, breast, ovarian, hepatocellular and adrenocortical), acute myeloid leukaemia, glioblastoma multiforme and  meduloblastoma. Mebendazole can induce the depolymerization of microtubules in neoplasms and newly formed vasculature, stopping tumor growth and neoangiogenesis, along with other proposed mechanisms of action.Keywords: Anthelmintic, Mebendazole, Cancer treatment, Antimicrotubullar effect, Antineoangiogenesis
MicroRNA-16 inhibits the migration and invasion of glioma cell by targeting Bcl-2 gene
Authors: Luo Baochang , Zhang Jing
Published: March 2021

Purpose: To investigate the effect of microRNA-16 (miR-16) on glioma cell migration and invasiveness, and the mechanism involved.Methods: MicroRNA-16 mimic or inhibitor was transfected into human glioma (SHG44) cells. Cell migration, invasiveness and morphology were determined using scratch test, Transwell invasion assay, and immunohistochemical staining, respectively. Expressions of bcl-2, MMP-9 and MMP-2, and NF-κB1 proteins were measured using Western blotting.Results: Overexpression of MicroRNA-16 significantly down-regulated MMP-9 protein in SHG44 cells (p < 0.05), but MMP-2 protein expressions in the 2 groups were comparable (p > 0.05). Protein expressions of MMP-9 and NF-κB1 were significantly down-regulated in human glioma positive cells, relative to negative control.Conclusion: MiR-16 overexpression suppresses the migration and invasiveness of SHG44 cells via the regulation of NF-κB1/MMP-9 signaling pathway, and it directly targets bcl-2 gene by inhibiting its protein expression. This finding affords a new target for developing new anti-glioma drugs.

Keywords: Bcl-2, Expression, Glioma, MicroRNA-16, NF-κB1signaling pathway
Retracted “Effect of Shensong Yangxin on heart failure in preserved ejection fraction rat model”
Authors: Zhang Weiwei , Sun Qian , Chen Hao , Zhang Qiang
Published: March 2021

This article previously published in Volume 17 Issue 12 of this journal in December 2018 has been retracted in line with the guidelines  from the Committee on Publication Ethics (COPE, http://publicationethics.org/resources/guidelines).
Retraction: Zhang W, Sun Q, Chen H, Zhang Q. Effect of Shensong Yangxin on heart failure in preserved ejection fraction rat model. Trop J Pharm Res 2018;  17(12):2427-2432 doi: http://dx.doi.org/10.4314/tjpr.v17i12.17
To the editor:Many readers have written to me with questions about my article. We have found out that there was anomission in the experimental design hence some of the results could not be repeated. Therefore, wedecided that the paper should be retracted to avoid misleading the readers. Sincerely, Qian Sun.
Keywords: Heart failure, Ejection fraction, Shensong Yangxin
Visible, Unrecognisable – Recognisable, Silenced? Representations of Evangelism in Permanent Museum Exhibits in Masuria
Authors: Sacha Magdalena Izabella
Published: March 2021

The article addresses representations of the Evangelical denomination at contemporary permanent museum exhibits in the region of Masuria, inhabited between 1525–1945 by a Protestant majority. Applying semiotic analysis, the author presents the outcomes of field studies in the local museums in Olsztyn, Mikołajki, Mrągowo, Ogródek, Szczytno, and in the open-air museum in Olsztynek. The principal research question is the issue of visibility and recognisability of Evangelism-related items at permanent exhibits. The author concludes that there are three types of omissions in the presentation of the history of Masurian Evangelicals. The silencing of the Protestant past of Masuria results from the cultural colonisation that took place after 1945 and from identifying Evangelicalism with Germanness in the common consciousness of the currently dominant Polish Roman Catholic community.
Estetyka komunikacji jako wyraz grzeczności
Authors: Laskowska Małgorzata
Published: March 2021

Podstawowym celem niniejszego artykułu jest określenie tego, na ile estetyka komunikacji jest wyrazem grzeczności. Szczególna uwaga zostanie zwrócona na znaczenie estetyki komunikacji werbalnej oraz niewerbalnej. Tak postawiony cel badawczy można przedstawić w następujących pytaniach szczegółowych: w jakim znaczeniu estetyka komunikacji może być formą grzeczności w komunikacji? W czym przejawia się estetyka komunikacji werbalnej oraz niewerbalnej? Artykuł ma charakter przeglądowy; zastosowano tu przede wszystkim metodę analizy zawartości literatury przedmiotu. Odpowiedzi na wymienione wyżej pytania, uzyskane w wyniku przeprowadzonej analizy, pozwolą zaproponować standardy bycia uprzejmym w komunikacji z uwzględnieniem estetycznych form przekazu. Aesthetics of Communication as an Expression of Politeness The main purpose of this article is to determine the extent to which the aesthetics of commu­nication is an expression of politeness. Particular attention will be paid here to the importance of the aesthetics of verbal and non-verbal communication. This research objective can be presented in the following specific questions: In what sense can the aesthetics of communication be a form of politeness in communication? How does the aesthetics of verbal and nonverbal communication manifest itself? The article is a literature review; therefore, the method of critical analysis of the subject literature was primarily used. The answers to the above-mentioned questions, obtained as a result of the conducted analysis allowed to recom­mend standards of being polite in communication, taking into account the aesthetic forms of communication.
Wspólnota śmiechu muzealników (Szkic do dalszych studiów)
Authors: Soćko-Mucha Alicja
Published: March 2021

Laughter Community of Museum Employees (A Research Note)

The subject of the article is the occupational humor of museum employees and the laughter community connected to it. The author shows which aspects of work in a museum trigger off comical effect according to the employees themselves. The research material comes from the author’s personal experiences as well as the interviews with other staff members and Facebook fanpage Muzealnicy. The author tries to answer the question concerning the cultural and social functions of the laughter community of museum employees. The theoretical framework of this analysis is provided by K. Żygulski’s concept of the “laughter community”.
Innowacja i nowość w branży medialnej w świetle teorii innowacyjności Josepha A. Schumpetera na przykładzie CNN
Authors: Teler Anna
Published: March 2021

Innovation and novelty in the media industry according to the theory of innovation by Joseph A. Schumpeter on the example of CNN

Demand for novelty is inscribed in the DNA of media and media organizations, especially those that specialize in delivering the latest news. This is a prerequisite for media consumption. The media organizations responsible for delivering new products to recipients, are subject to market laws, compete, achieve an advantage, fight for survival in the turbulent environment of the media and technology –and therefore remain in constant development. According to Joseph A. Schumpeter, development is possible by introducing innovations. Schumpeter’s Theory of Innovation was a research tool for an analysis of the CNN group, specializing in information for 24/7.
Rola marketingu społecznościowego w zarządzaniu relacjami z widzami seriali telewizyjnych na przykładzie produkcji Zakochani po uszy
Authors: Wielkopolan Martyna
Published: March 2021

The role of social media marketing in television viewer relationship management based on the TV production 'Zakochani po uszy'

Social media marketing is becoming the main aspect of strategies implemented by traditional media workers. The aim of the study is an analysis of an impact this kind of internet marketing has on television viewer relationship management, in the form of case study. The author’s intention was to do the qualitative research on the TV production Zakochani po uszy created by TVN, including its promotion through an official profile on the social networking site called Instagram in terms of building relationships with viewers along with holistic and deepened description of analysed phenomena. In the study, the author presents the results of the research based on non-participant observation of the official profile of Zakochani po uszy on Instagram, in-depth interview with a person responsible for public relations of the series, results of the survey along with data analysis, which contains viewership and statistics from analysed profile. These activities enabled solving the research problem phrased as a question: how is the strategy, which is to create strong relations with viewers, formulated and answering detailed research questions posed in the study.
Live video streaming na platformie YouTube – zarządzanie treściami o charakterze nienawistnym
Authors: Cyrek Barbara
Published: March 2021

Live video streaming on YouTube – management of a hateful content

The purpose of the article is to characterize current issues related to the occurrence of hate speech in live broadcasts on YouTube. Adding more tools to make the platform more attractive to users also gives new opportunities to spread hateful content. Platform policy must be constantly evolving, and subsequent regulations are widely commented on by both advertisers and users. For live broadcasts, real-time control requires automated solutions that are sometimes fallible.
Representing uncertainty in the Rescorla-Wagner model: Blocking, the redundancy effect, and outcome base rate
Authors: Spicer Stuart G. , Wills Andy J. , Jones Peter M. , Mitchell Chris J. , Dome Lenard
Published: March 2021

It is generally assumed that the Rescorla and Wagner (1972) model adequately accommodates the full results of simple cue competition experiments in humans (e.g. Dickinson et al., 1984), while the Bush and Mosteller (1951) model cannot. We present simulations that demonstrate this assumption is wrong in at least some circumstances. The Rescorla-Wagner model, as usually applied, fits the full results of a simple forward cue-competition experiment no better than the Bush-Mosteller model. Additionally, we present a novel finding, where letting the associative strength of all cues start at an intermediate value (rather than zero), allows this modified model to provide a better account of the experimental data than the (equivalently modified) Bush-Mosteller model. This modification also allows the Rescorla-Wagner model to account for a redundancy effect experiment (Uengoer et al., 2013); something that the unmodified model is not able to do. Furthermore, the modified Rescorla-Wagner model can accommodate the effect of varying the proportion of trials on which the outcome occurs (i.e. the base rate) on the redundancy effect (Jones et al., 2019). Interestingly, the initial associative strength of cues varies in line with the outcome base rate. We propose that this modification provides a simple way of mathematically representing uncertainty about the causal status of novel cues within the confines of the Rescorla-Wagner model. The theoretical implications of this modification are discussed. We also briefly introduce free and open resources to support formal modelling in associative learning.

Keywords: associative learning, prediction error, uncertainty, modelling, blocking, redundancy effect, open science.
Anthropometric Prediction of Visceral Adiposity in Persons With Spinal Cord Injury
Authors: Gorgey Ashraf S. , Ennasr Areej N. , Farkas Gary J. , Gater David R.
Published: March 2021

Over two-thirds of persons with spinal cord injury (SCI) experience neurogenic obesity-induced cardiometabolic syndrome (CMS) and other chronic comorbidities. Obesity is likely to impede social and recreational activities, impact quality of life, and impose additional socioeconomic burdens on persons with SCI. Advances in imaging technology facilitate the mapping of adiposity and its association with the cardiometabolic profile after SCI. Central adiposity or central obesity is characterized by increased waist (WC) and abdominal circumferences (AC) as well as visceral adipose tissue (VAT). A number of studies, while relying on expensive imaging techniques, have reported direct associations of both central obesity and VAT in imposing significant health risks after SCI. The mechanistic role of central obesity on cardiometabolic heath in persons with SCI has yet to be identified, despite the knowledge that it has been designated as an independent risk factor for cardiometabolic dysfunction and premature mortality in other clinical populations. In persons with SCI, the distribution of adipose tissue has been suggested to be a function of sex, level of injury, and age. To date, there is no SCI-specific WC or AC cutoff value to provide anthropometric prediction of VAT and diagnostic capability of persons at risk for central obesity, CMS, and cardiovascular disease after SCI. The purpose of the current review is to summarize the factors contributing to visceral adiposity in persons with SCI and to develop an SCI-specific anthropometric prediction equation for this population. Furthermore, a proposed WC cutoff will be discussed as a surrogate index for central obesity, CMS, and cardiovascular disorders after SCI.
Interrelationship of Neurogenic Obesity and Chronic Neuropathic Pain in Persons With Spinal Cord Injury
Authors: Felix Elizabeth R. , Gater David R.
Published: March 2021

The prevalence of obesity and of neuropathic pain are both estimated at above 50% in the population of people with chronic spinal cord injury (SCI). These secondary consequences of SCI have significant negative impact on physical functioning, activities of daily living, and quality of life. Investigations of relationships between weight or body composition and chronic neuropathic pain in people with SCI are lacking, but investigations in non-SCI cohorts suggest an association between obesity and the presence and severity of neuropathic pain conditions. In the present article, we present a review of the literature linking obesity and neuropathic pain and summarize findings suggesting that metabolic syndrome and chronic, systemic inflammation due to excess adiposity increase the risk for neuropathic pain after an SCI.
Optimal Design of Wind/PV/Diesel/Battery Power System for telecommunication application in a remote Algeria
Authors: Zeraia H. , Larbes C. , Malek A.
Published: March 2021

Algeria has embarked on an ambitious renewable energy program in order to increase total food production. It has a large number of remote small villages and islands that lack in the electricity, and probability of connecting them with the high voltage gridlines in the near future is very poor due to financial and technical constraints. This paper proposes the use of a PV, wind and diesel generator hybrid system with storage element in order to determine the optimal configuration of renewable energy in ALGERIA. The principals’ interests of this system are the independence production, and the supplying of electric energy in isolated localities. Have at one’s the energetic and economic models, and simulation tools, we effected an optimization study based on mixed productions. For this approach, the energetic resources of sites where are implanted telecommunications systems and their consumption are supposed known. Then the problem is the optimization of electric generators using these resources, enable to have an optimal type system for the powering of telecommunications equipments in rural site of Algeria. Homer (hybrid optimization model for electric renewable) simulation software was used to determine the technical feasibility of the system and to perform the economical analysis of the system.
Leakage Reduction Methodology in CMOS for the Design of 1-Bit Full Adder
Authors: DAS S. MOHAN , M GANESH KUMAR , K BHASKARA RAO
Published: March 2021

This paper presents low leakage and high speed 1-bit full adder projected with low threshold NMOS transistors in associations with universal logic gates which leads to have reduced power and delay. The customized NAND and NOR gates, a necessary blocks, are presented to design a proposed adder cell. The simulations for the designed circuits performed in cadence virtuoso tool with 65 nm CMOS technology at a supply voltage of 1 Volts. The proposed universal gates and 1-bit adder cell is compared with conventional NAND/NOR gates and 1-bit adder. The proposed adder schemes with modified universal logic gates achieve significant saving in terms of delay which are more than 24% and which is at the cost of 5% when compared with conventional designs.
Evaluación vertical y horizontal: Una integración entre el Supply Chain Operations Reference y el Balanced Scordcard / Vertical and horizontal evaluation: An integration between the Supply Chain Operations Reference and the Balanced Scordcard
Authors: Cruz Aldana Eduardo , Guerrero Azpeitia Luis Arturo
Published: March 2021

De manera tradicional, en la gestión de la cadena de suministro los indicadores del Balanced Scordcard (BSC) tienen como premisa traducir la estrategia en medidas de desempeño desde niveles directivos hasta los niveles operativos, en tanto que el modelo Supply Chain Operations Reference (SCOR) proporciona elementos para la planeación y control de flujos tanto de materiales como de información. En este contexto, la pregunta de investigación fue ¿De qué manera se puede integrar el BSC y el SCOR con la finalidad de establecer relaciones y grados de incidencia entre indicadores que permitan evaluar el desempeño de la cadena de suministro? Para responder dicha pregunta, se planteó como objetivo diseñar una propuesta de integración entre el BSC y SCOR con la finalidad de diseñar una propuesta de modelo de integración entre el BSC y SCOR con la finalidad de integrar la evaluación del desempeño de la cadena de suministro. La estrategia metodológica adoptada se sustentó en la investigación documental y en el método comparado que, en este caso, tuvo como unidades de análisis las estrategias para la evaluación del desempeño mediado por indicadores logísticos. La articulación teórico-metodológica seleccionada permitió concretar la interrelación de las cuatro perspectivas del BSC y de los cinco procesos primario de gestión del SCOR misma que se mediatizó en un modelo de integración que puede coadyuvar a optimizar el rendimiento de la cadena de suministro. Finalmente, como conclusiones se establece la viabilidad del modelo aquí propuesto para la evaluación del desempeño de la cadena de suministro de manera tanto horizontal como vertical para su implementación y valoración empírica.
Convince me you exist. An analysis of The Kurdistan Workers Party (PKK) court files
Authors: Sargi Islam
Published: March 2021

The end of empires and the rise of nation-states have transformed the way politics and societies operate and the modern sense of these changes, transformations, events, and situations. Language, culture, and memory are essential pillars of the nation-states’ projects of creating a new society. The modern form of government, the nation-state, use history not only as a means of transmission but also as a means of building identity and memory. This study examines the case files of three critical names in the Kurdish movement and the history-based debates in their trials. By applying discourse analysis, we have shown how the Turkish state and The Kurdish Workers’ Party used history as a tool to “prove” and “disprove” the existence of Kurds, the Kurdish language, and Kurdistan. While the judges imposed an evidence-based approach to history and denied the existence of Kurds, Kurdish and Kurdistan, the PKK members opposed the official thesis of the state and built their arguments more on the day-to-day realities of life.  The study’s main argument is that the official ideology uses history to prove and convey a message to the rest of society, whereas the defendants used it as a means of protest depending on the historical reality rather than history as a science. This study discusses that by using science to make examples of these members, the judges used history to prove the Kurds’ non-existence, whereas the defendants implied history as a way of protesting the ruling authority.
Human Capital Development and Industrialization in Nigeria: Implication for Economic Growth
Authors: Saka Jimoh , Olanipekun Dayo Benedict
Published: March 2021

This paper examines the role that human capital plays in the relationship between the industrialization process and growth in Nigeria spanning the period 1980 to 2016. The theoretical framework is rooted in one of the new growth theories traceable to Lucas (1988) with emphasis on human capital's role in growth. Through some modifications, we result in two simultaneous equation models, one with growth as a dependent variable and the other, industrialization as a dependent variable. Human capital is disaggregated into male and female literacy rates, male and female life expectancies and other control variables used to explain the growth and industrialization process. The Two-Stage Least Squares adopted gives the expected outcome in most cases for the two model estimations. It is shown that the industrialization process is germane for economic growth, and likewise, male literacy rates can complement the industrial process to improve growth. In the same vein, stable growth facilitates the process of industrialization while human capital variables too play a relevant role in the same process. Identification of the workings of the Nigerian state would be a good foundation for the step towards ameliorating the problems of capacity building and industrialization in Nigeria.
Las palabras y la cultura. Lengua, globalización e interculturalidad / Words and culture. Language, globalization and interculturality
Authors: Bakhronova Dilrabo
Published: March 2021

La globalización supone una problemática que puede ser entendida desde distintas aristas, principalmente como factor económico-comercial, sin embargo, su expansión a otros campos de la vida, atrae múltiples ventajas, pero también afectaciones a las sociedades del siglo XXI. La cultura utilizada como mecanismo de poder para homogeneizar a las culturas locales, así como servirse de la lengua para entronar un idioma, un estilo de vida, moralidad, costumbre, etc. De ahí, que el objetivo del presente artículo es realizar un análisis del uso del lenguaje en la cultura globalizada. Para este efecto se utilizan algunos ejemplos de cómo el lenguaje y la cultura, efectivamente, ha cruzado fronteras y se instala en el imaginario social provocando una hibridación que roza con los componentes de la identidad nacional/cultural.
Un mismo concepto metafórico. Fraseología e interculturalidad en las aulas / The same metaphorical concept. Phraseology and interculturality in the classroom
Authors: Dushayeva Umida
Published: March 2021

Desarrollar instrumentos que permitan contribuir a una educación intercultural, se vuelve cada vez más importante, sobre todo por los flujos migratorios que se experimentan en el mundo globalizado del siglo XXI. Históricamente las sociedades, sobre todo latinoamericanas, no han sido capaces de incluir al otro, al contrario, los migrantes han sido objeto del rechazo mayoritario, de ahí la necesidad de construir sociedades incluyentes, tolerantes. Como cada vez es más común encontrar aulas en las que comparten clases estudiantes procedentes de distintos países y regiones, este artículo se propone destacar a la enseñanza de la fraseología como recurso integrador en los procesos migratorios en la región andina, sobre todo en Ecuador. Se encuentra que la fraseodidáctica puede ayudar a desarrollar otras competencias no lingüísticas, como la conciencia y expresiones culturales de quienes comparten un aula de clases.
NOVI NAČIN UPOTREBE OKSALNE KISELINE ZA SUZBIJANJE VAROE U CRNOJ GORI
Authors:   Biotechnical Faculty, Montenegro, Jaćimovic Vučeta , Bojanic – Rasovic Mirjana , Đurovic Veljko , Tomovic Lazar
Published: March 2021

In Montenegro, Varoa (Varoa destructor) causes a lot of damage to bee colonies. Beekeepers decide on various ways to control varroa, and that is mainly the use of formic acid (August - September) and oxalic acid (October - November), then thymol-based products - Apiguard and Api Life Var. In practice, many beekeepers perform smoke treatment, based on amitraz, after removing the semi-extensions or extensions. This paper will show the pioneering steps in the use of products based on oxalic acid and essential oils, and very early treatment, from August 1. The preparation was kept for 42 days in bee colonies and a significant result was achieved in the destruction of varroa.
SINTEZA I STRUKTURA BAKTERIJSKE CELULOZE PRIMENOM BAKTERIJA SIRĆETNOG VRENJA
Authors:   The Academy of Applied Technical Studies Belgrade, Serbia, Janicijevic Aleksandra , Filipovic Suzana ,   Institute of Technical Sciences of SASA, Belgrade, Serbia, Pavlovic Vladimir B. ,   University of Belgrade, Faculty of Agriculture, Sknepnek Aleksandra ,   University of Belgrade, Faculty of Agriculture, Kovacevic Danijela ,   The Academy of Applied Technical Studies Belgrade, Serbia, Đorđevic Nenad ,   The Academy of Applied Technical Studies Belgrade, Serbia, Mirkovic Miljana ,   Institute of Nuclear Sciences Belgrade, Serbia, Živkovic Predrag ,   University of Belgrade, Faculty of Technology and Metallurgy
Published: March 2021

As one of the most common biopolymers on Earth, cellulose has found an important role in food industry, biomedicine andbiotechnology. The process of obtaining cellulose fibers is often followed with the presence of the byproduct, whose removal is required procedure. From that reason, the process of obtaining material on a bacterial cellulose (BC) basis,finds wide application in everyday life. Having in mind her many features, we have investigated the change in structure and morphology of BC depending on the synthesis parameters. The influence of the medium volume and different time intervals of NaOH treatment relative to different BCN yields and structure. The mentioned changes were examined by XRD, FTIR spectroscopy, as well as SEM and EDS analyzes.
EFIKASNOST KOMBINACIJE MEZOTRIONA I TERBUTILAZINA IZ RAZLIČITIH PREPARATA U USEVU KUKURUZA
Authors:   University of Novi Sad, Faculty of Agronomy, Meseldzija Maja , Dudic Milica , Begovic Radovan , Marjanovic Ivana
Published: March 2021

The aim of study was to test the efficacy and phytotoxicity of Calaris pro (326 g kg-1 terbuthylazine+50 g kg-1 mesotrione) and Twister (125 g kg-1 terbuthylazine+50 g kg-1 mesotrione) on weeds in maize crop. The experiment was set up during 2017 at the Kruščić, by a random block system in four repetitions. High efficacy of herbicides was manifested on Abutilon theophrasti, Amaranthus retroflexus, Ambrosia artemisiifolia, Chenopodium album, Chenopodium hybridum, Cirsium arvense, Datura stramonium, Solanum nigrum, Setaria glauca, Hibiscus trionum and Xanthium strumarium, while low efficacy was on Sorghum halepense. The total efficacy for product Calaris pro was 94,16% and for Tvister 96,20%.
EFIKASNOST RAZLIČITIH FUNGICIDA U SUZBIJANJU PROUZROKOVAČA PLAMENJAČE SPANAĆA
Authors:   Institute of Field and Vegetable Crops, Novi Sad, Vlajic Slobodan , Gvozdanovic - Varga Jelica , Masirevic Stevan , Ignjatov Maja , Milosevic Dragana , Tamindzic Gordana
Published: March 2021

Powdery mildew of spinach cause significant damage in agriculture production reducing the value usage of the leaves. Considering that there are no registered fungicides for controlling the powdery mildew of spinach in the Republic of Serbia, the aim of the research was to examine various fungicides for preventive and therapeutic usage. The study included seven synthetic and one biological fungicide. The lowest intensity of infection in preventive (0.10%) and therapeutic (0.33%) treatment was found when using a combination of active substances famoxadone + cimoxanil. However, when choosing and applying fungicides in spinach, special attention must be dedicate to the withdrawal period of the formulated products.
ISPITIVANJE EKSTRAKATA ORIGANA DOBIJENIH RAZLIČITIM METODAMA
Authors:   University of Kragujevac, Faculty of Agronomy, Mladenovic Jelena , Markovic Veronika , Boskovic-Rakocevic Ljiljana , Đuric Milena , Pavlovic Nenad
Published: March 2021

Oregano is used in the production of specific aromatic cheeses, meat products and dough dishes, for the production of medicinal preparations, fragrant soaps, colognes and perfumes. Special interest in oregano in recent years is related to the results of a study of its biological activities, which indicate a wide range of antibacterial, fungicidal, antiviral and antioxidant properties. The subject of this paper is the examination of extracts of plant species of oregano (Origanum vulgare), with the aim of determining the method that is most popular for extracting this plant species and which gives the best yields of extracts. The content of extracted substances in each extract, the content of vitamin C as well as the content of organic acids were determined.
Clinical Study of Risk Factors for Diabetic Maculopathy
Authors: Bangal Dr. Surekha V. , Patil Dr. Bhushan , Sharma Dr. Akshita
Published: March 2021

Aim: To determine the association between various systemic risk factors with diabetic maculopathy. Methodology: A prospective observational study was conducted on 50 patients having diabetic maculopathy. Patients with maculopathies secondary to Vitreous Haemorrhage, Ocular disorders like Glaucoma, Uveitis, Advanced Diabetic Eye Disease, Vitreo-macular traction, maculopathy along with proliferative diabetic retinopathy, ischemic maculopathy, and history of laser treatment in last six months were excluded from the study. Data was collected using a structured proforma that included name, age, sex, occupation, height, weight, history of other systemic diseases like hypertension, investigations and treatment taken in past, family history, duration  of DM, smoking, hyperlipidemia, hyperglycemia and nephropathy. Results: Out of 50 patients, 38 (76%) were males and 12 (24%) were females suggestive of male predominance. Mean age of the patient was 57.36±11.65 years in males and 56.67±10.17 years in females. Among 50 patients, 19 patients had diabetes mellitus for 6-10 years duration, 14 patients had diabetes mellitus for 1-5 years, in 12 patients for 11-15 years, in 2 patients for 16-20 years, in 2 patients for 21-25 years and only 1 patient more than 25 years. Mean duration of DM was 12.2±6.1 years. Majority of patients having maculopathy had duration of DM up to 20 years. Among 50 patients, 27 patients (54%) had systemic hypertension, 37 patients (74%) had uncontrolled blood sugar level, 29 patients (58%) were found to have hyperlipidemia and 20 patients (40%) had nephropathy. Among 50 patients, pseudophakia was noted in 7 patients (14%), obesity was noted in 21patients (42%). Eleven patients (22%) were found to have anemia, 6 patients (12%) had family history of DM and 13 patients (26%) had history of smoking. Conclusion: Hyperglycemia, hypertension, duration of DM, hyperlipidemia are the major risk factors for the development and progression of diabetic maculopathy. While anemia, smoking, and obesity, family history of DM are the less significant risk factors.
Newer Therapies In Management of Neonatal Birth Asphyxia
Authors: Shinde Dr. Abhijit , Mhaske Prof. Dr. Sunil Natha , Dr. Sushrut Kumar
Published: March 2021

Asphyxia is an insult to the fetus or newborn due to lack of oxygen or lack of perfusion to various organs.1 National Neonatology Forum of India has defined asphyxia as gasping or ineffective breathing or lack of breathing at 1 min of life.2Birth asphyxia is one of the most important causes of neonatal brain injury whose incidence ranges from 3.7 to 9/1000 deliveries in the west.3 With the advent of therapeutic hypothermia (TH), improved outcomes are being reported in moderate HIE. TH, however, has not demonstrated improvement in outcomes related to severe HIE. . This has led clinicians and researchers to continue evaluating complementary and/or alternative therapies for infants with HIE. In this review, we will discuss current and emerging therapies in the management of HIE, other than hypothermia. With issues of access to health care and the burden of birth asphyxia shifting to developing and least developed nations, there is a need for alternative and supplementary neuroprotective agents. Low cost and easy availability along with ease of use would assist in ensuring that these therapies have global applicability. So global efforts must be taken to increase such studies as birth asphyxia is causing more morbidity & mortality globally.
KEPEMIMPINAN SITUASIONAL KEPALA MADRASAH DALAM MENINGKATKAN HASIL BELAJAR PESERTA DIDIK PADA MTS AL WASHLIYAH PADANG MATINGGI
Authors: Aliamsah Ritonga Candra Wijaya, Syamsu Nahar,
Published: March 2021

Abstrak: Penelitian ini bertujuan untuk menganalisis: 1)  Strategi kepala sekolah dalam meningkatkan motivasi belajar siswa di MTs Al Washliyah Padang Matinggi; 2)  Bentuk-bentuk motivasi belajar untuk Meningkatkan Hasil Belajar siswa di di MTs Al Washliyah Padang Matinggi; 3)  Faktor pendukung dan penghambat pada strategi kepala sekolah dalam meningkatkan Hasil Belajar belajar siswa di MTs Al Washliyah Padang Matinggi. Penelitian menggunakan pendekatan kualitatif. Hasil penelitian ini mengungkapkan Tiga temuan yaitu: 1) MTs Al Washliyah Padang Matinggi bahwa semua melakukan motivasi terhadap siswa agar semangat belajarnya tinggi, akan tetapi ada guru yang sering melakukan itu, ada juga guru yang jarang melakukan itu; 2) bentuk-bentuk strategi kepala madrasah dalam meningkatkan motivasi belajar siswa maka dapat disimpulkan bahwasannya MTs Al Washliyah Padang Matinggi banyak bentuk motivasi yang dilakukan, seperti membuat program seperti: Membuat olimpiade untuk para murid, Membuat penilaian murid terbaik, Membuat penilaian siswa terajin, Pemilihan kelas terbaik setiap akhir bulan, Program sedekah terbanyak setiap minggu dan Program walikelas terbaik; 3) MTs Al Washliyah Padang Matinggi memiliki beberapa faktor pendukung dan penghambat pada strategi motivasi belajar siswa.

Kata Kunci: Kepemimpinan dan Hasil Belajar
Antropologia teatrale e performance studies. Assonanze e tracce della ri(n)voluzione performativa postmoderna.
Authors: Giraldo Mabel
Published: March 2021

Starting from the finding of the performative drift that marked the theatrical research through the Seventies and Eighties, this essay aims to show how two of the main protagonists of the period – Theatre Anthropology and Performance Studies – have contributed in their affinities and specificities to marginalizing of the theatre as a cultural phenomenon and devaluating of the artistic work, inaugurated (and not yet rectified) by Postmodernity.
Technical Inefficiency Determinants in Potato Production: The case of Potato Farmers in Central Highlands of Ethiopia
Authors:   Department of Agricultural Economics, Ethiopian Institute of Agricultural Research (EIAR), P.O. Box 2003, Addis Ababa, Ethiopia,, Hailu Daniel
Published: March 2021

The study identified the factors that cause variation in the level of efficiency in potato production. The study used household level cross sectional data collected in 2015/16 from 196 sample farmers selected by multistage sampling technique. For the data collection, a personally administered structured questionnaire was used. In the analyses, descriptive statistics, a stochastic frontier model (SFM) and a two-limit Tobit regression model were employed. Tobit model revealed that technical efficiency was positively and significantly affected by education, land tenure status, extension service, credit and soil fertility whereas variables such as sex of household head, age of household head, farm size and land fragmentation affected it negatively. Therefore the study suggested the need for policies to discourage land fragmentation and promote education, extension visits, access to credit and soil fertility for improvement in technical efficiency.
HISTORICAL AND THEORETICAL APPROACH TO THE PROBLEM OF GENRE IN MODERN RUSSIAN LITERATURE STUDIES
Authors:   Senior Lecturer, Department of Russian Literature and Teaching Methods, Faculty of Russian Philology, Uzbek State University of World Languages, OSIPOVA AGATA VIKTOROVNA
Published: March 2021

The article is devoted to the study of the peculiarities of the genre in Russian literary criticism. A brief overview of the research opinions of prominent scientists on the problem of the genre system and its evolution is given. An attempt is made to investigate the transformation of the genre of the modern story. Particular attention is paid to the change in the genre nature of the story as a result of the artistic interpretation of reality by contemporary Russian postmodernists.
Implementasi Pendidikan Quran Tingkat Lanjut Bagi Santri Usia Dewasa
Authors: Rahayu Supriati H. , Huda Hidayatul , Wahono Joko , Nadjih Difla , Sarnoto A. Zain
Published: March 2021

The researchers intends to find out how Al-Quran Education in the Yogyakarta AMM Tartil Team includes supporting and inhibiting factors as well as how the team overcomes the obstacles to Al-Quran Education in the AMM Tartil Team Yogyakarta. The learning patterns of adults and advanced readers of the Quran in this education are different from those of students of Quran who are younger than them at the beginning level or those studying in Islamic boarding schools. This qualitative case study research uses several instruments, observation, mandala interviews, and documentation. Observations were made by directly following the Syahadah One education process for the students of the AMM Yogyakarta tartil team. In-depth interviews were addressed to informants, namely the management of the Foundation, Ustaz, and students participating in the education who were the object of the research. For documentation, it is emphasized on the data of the Tartilil Qur'an curriculum text. All collected data were then analyzed in a cumulative manner with inductive-deductive thinking patterns. Advanced education to read the Koran does have complex problems in terms of time and age of the participants, although it must be commended for their intention and sincerity to be fluent in reading it.
Pengembangan Kewirausahaan Berbasis Industri Kreatif Bagi Jamaah Wanita Majelis Taklim Di Desa Kepek
Authors: Musaropah Umi , Suharto Suharto , Delimanugari Daluti , Suprianto Agus , Rubini Rubini , Kurnianingsih Retno , Ayudiati Citra
Published: March 2021

Entrepreneurship development based on creative industries for women congregation majelis taklim (MT) in Kepek village is carried out using the PAR (Participation Action Research) method which aims to encourage creative minds by pressing questions and participant-oriented guidance. Entrepreneurship development for MT female congregation in Kepek Gunung Kidul village can be achieved well. Among others are; There needs to be a follow-up in a series of mentoring and skills improvement, both for the main and supporting the business. The potential for good local wisdom can be converted into economic values. Massive development of marketing networks needs to be considered in order to have a bigger economic impact on the surrounding community. The government is advised to support deeper exploration of the local economic wisdom of the people of Gunung Kidul so that it can have a direct positive impact on its residents.
O fim das Ilusões: a Crise Econômica e seus impactos sobre os modelos de gestão
Authors: Souza Agamêmnom Rocha , Ferreira Victor Cláudio Paradela
Published: March 2021

A crise que se abateu recentemente sobre a economia trouxe mais do que os notórios problemas sociais e econômicos. A falência ou grave enfraquecimento de empresas, até então consideradas referências de competitividade, deixou atônitos muitos analistas organizacionais. Os problemas que se abateram sobre tais corporações revelaram a fragilidade dos modelos de gestão por elas adotadas. O presente artigo tem como foco a análise crítica das teorias administrativas. Inicialmente, são apresentados os princípios básicos das primeiras contribuições teóricas, destacando-se suas limitações. São, também, analisados os modelos, surgidos no fim do século passado, pretensamente mais modernos, mas igualmente parciais e falhos. Em seguida, são destacadas algumas contribuições teóricas que, longe de proporem novas receitas de sucesso, têm como foco a complexidade que marca a sociedade atual e a consequente necessidade de revisão dos postulados teóricos da administração.
Perfil Nutricional de Idosas frequentadoras da Faculdade da Terceira Idade Nutritional profile of elderly who frequent The Third Age Faculty
Authors: Guimarães Érica Cristina Moreira , Dos Santos Lorena Silva , De Jesus Bruna Moraes , Pastana Natalia Almeida , Saron Margareth Lopes Galvão
Published: March 2021

O objetivo deste foi avaliar o perfil nutricional de idosas frequentadoras da Faculdade da Terceira Idade, de São José dos Campos, Estado de São Paulo. A pesquisa foi transversal e controlada, constituída por 40 idosas, com média de idade de 68,22 anos. Foi realizada a avaliação antropométrica (índice de massa corporal, circunferência da cintura, razão cintura-quadril, prega cutânea triciptal e circunferência muscular braquial) e aplicação do inquérito alimentar. Os resultados mostraram inadequação do estado nutricional da maioria (52,5%) das idosas pelo índice de massa corporal, circunferência da cintura (75%) e razão cintura-quadril (90%). A maioria das idosas apresentou adequação em relação à reserva de tecido adiposo e muscular braquial.  Verificou-se neste grupo uma baixa ingestão de fibra alimentar, com média de 10,76 g. Pode-se concluir que prevaleceu a inadequação do estado nutricional, indicativa de sua maior susceptibilidade à morbidade e à mortalidade e inadequação pela maioria idosas em relação ao consumo alimentar de fibra.