bluuebunny/crossref_metadata_2025 huggingface dataset:
IMPROVED DISSOLUTION OF IBUPROFEN BY SOLID DISPERSION SYSTEM AND THE INCORPORATION INTO PELLETS&NBSP;
Authors: Le Hoang Hao , Nguyen Phi Quang , Ho Hoang Nhan
Published: June 2022

Background and purposes: Ibuprofen is a commonly used NSAID for anti-inflammatory, antipyretic, analgesic, and antiplatelet agents. However, Ibuprofen is poorly soluble in water and its bioavailability is low. Pellets containing the solid dispersion system are considered as a drug delivery system with many outstanding advantages such as improving the stability, the solubility as well as the dissolution rate, thus increasing the bioavailability. The aim of this study was to formulate pellets containing the solid dispersion system of ibuprofen, and to evaluate the physico-chemical properties of prepared pellets. Materials and methods: Ibuprofen, PVP K30 were used in this study. Pellets were prepared by the layering technique based on the solvent method used in preparing the solid dispersion system of Ibuprofen. Results: The preparation of a solid dispersion system of ibuprofen using PVP K30 as a carrier helps to improve both the appearance and the drug solubility at the optimal drug: PVP K30 ratio of 1:10 (w/w). Pellets have a spherical shape with the size in the range of 0.7-1.0 mm, the coating efficiency of 33.27%, the drug release of pellets was 7-fold higher than that of the raw material after 60 min. Conclusions: The incorporation of Ibu-loaded solid dispersion system into pellets contributed to enhance the dissolution of Ibuprofen as compared with the raw material.
Key words: Ibuprofen, pellet, solid dispersion system.
GLAUCOMA SITUATION AND RELATED FACTORS OF PERSONS OVER 40 YEARS OLD IN HUE CITY
Authors: Tran Nguyen Tra My , Nguyen Minh Tam , Phan Van Nam
Published: June 2022

Introduction: Glaucoma is a common eye disease that is quite dangerous to public health as one of the major causes of permanent blindness. Although glaucoma can be prevented, most glaucoma patients are underdiagnosed. It’s require a screening system to help patients detect glaucoma and treat it promptly. Objective: 1) To describe the glaucoma situation of person over 40 years old in Hue city. 2) To find out some factors related to glaucoma at study sites. Methods: A desciptive cross-sectional method was conducted with 2025 people over 40 years old in 27 wards of Hue city. Results: The percentage of glaucoma is 4.7%, with closed glaucoma accounting for 55.2%, with 9.1% of people suspected of glaucoma. The percentage of
glaucoma patients suffering from blindness was 21.7%. There was an association between glaucoma and age, gender, hypertension, diabetes, cardiovascular disease, family history of glaucoma, previous history of ocular surgery. Conclusions: The percentage of glaucoma is 4.7%, blindness is 21.7%, glaucoma is related to age, gender, hypertension, diabetes, cardiovascular disease, family history of glaucoma, preoperative eye surgery.
Key words: Glaucoma, people over 40 years old
A STUDY OF EVALUATION OF THYROID FUNCTION STATUS IN CONTINOUS AMBULATORY PERITONEAL DIALYSIS PATIENTS
Authors: Doan Thi Thien Hao , Hoang Bui Bao
Published: June 2022

Background/Aim: End-stage-renal-disease (ESRD) patients/CAPD have a high rate of abnormal thyroid hormone (include subclinical hypothyroidism and non-thyroidal illness syndrome) compared with those without kidney disease. These thyroid dysfunctions are associated with higher death risk due to cardiovascular disease in the general population, little is known about the effect of thyroid disease in patients received peritoneal dialysis. Methods: Cross-sectional research, 118 participants (59 healthy people, 57 CAPD patients) were enrolled. We examined the association of thyroid status, assessed by serum TSH, free T3, free T4 levels which were measured by immunoassay method. Results: Mean serum TSH level of patients were higher than those of control group, p<0.05 (3.15±2.28 μUI/mL versus 1.65±0.82 μUI/mL); mean FT3 level of patients were lower than those of control group, p<0.05 (2.42±0.46 pg/mL versus 3.01±0.41 pg/mL); mean FT4 level of
patients were lower than those of control group, p>0.05(1.26±0.24 ng/dL vs 1.18±0.18 ng/dL). Among 57 CAPD patients, 35.1% abnormal thyroid function; 19.3% subclinical hypothyroidism; 15.8% low FT3; 1 patient has low FT4. Mean serum TSH level of patients were higher than those of control group, p<0.05 (3.15±2.28 μUI/mL versus 1.65±0.82 μUI/mL); mean FT3 level of patients were lower than those of control group, p<0.05 (2.42±0.46 pg/mL versus 3.01±0.41 pg/mL); mean FT4 level of patients were lower than those of control group, (p>0.05, 1.26±0.24 ng/dL vs 1.18±0.18 ng/dL). Conclusion: Subclinical hypothyroidism and low FT3syndrome are high in CAPD patients. Additionally, FT4 serum concentration is associated with PD duration and serum creatinine; FT3 is dependent risk factor of rate Kt/V Urea weekly, also cardiovascular disease.
Key words: ambulatory peritoneal dialysis, continous ambulatory peritoneal dialysis patients (CAPD), abnormal thyroid function, subclinical hypothyroidism
ELECTROLYTE ABNORMALITIES IN PRETERM NEONATES
Authors: Nguyen Thi Thanh Binh , Nguyen Thi Quynh Nhu
Published: June 2022

Background: Electrolyte abnormalities are common in preterm neonates. Unless electrolyte abnormalities are detected and treated promptly, it significantly affects clinical conditions, increases mortality, or induces long-term neurological sequelae. Therefore, we conducted this study with specific aims to describe the electrolyte status in preterm neonates and find out the relationship between electrolyte disorders and clinical characteristics in preterm neonates. Methods: This was a cross-sectional descriptive study carried out with 110 preterm neonates admitted at the NICU in Hue University of Medicine and Pharmacy Hospital and Hue Central Hospital from June 2020 to March 2021. Results: Average serum values of sodium, potassium, chloride were 136.66; 4.59, and 101.72 mmol/l, respectively. Hyponatremia was the most common disorder with 30.9%, followed by hyperkalaemia (14.5%). Hypochloremia was accounted for 13.6%. Gestational age, birth weight, and asphyxia were significantly associated with the risk of hyperkalaemia (odd ratio: 5.27; 14.92; and 20.71, respectively). Birth weight, vomiting, and asphyxia were significantly linked to increased risk of hyponatremia in preterm neonates (odd ratio: 4.45; 28.13, and
3.49, respectively). Conclusion: The two common types of electrolyte disorders in preterm neonates were hyponatremia and hyperkalaemia.
Key words: Hyperkalaemia, hyponatremia, preterm neonates.
BLASTOCYST CULTURE IN IN-VITRO FERTILIZATION IN WOMEN WITH POLYCYSTIC OVARY SYNDROME
Authors: Nguyen Van Trung , Nguyen Thi Thai Thanh , Cao Ngoc Thanh , Le Minh Tam
Published: June 2022

Objective: This study aimed to evaluation of formation and development of blastocyst in in-vitro
fertilization in women with polycystic ovary syndrome. Methods: Retrospective study on 53 women with
PCOS and 52 women with non-PCOS, who underwent in-vitro fertilization with blastocyst culture at Center
for Reproductive Endocrinology and Infertility, Hue University of Medicine and Pharmacy Hospital since
January 2019 until December 2020. Results: In women with PCOS, ovarian stimulation resulted in a greater
number of retrieved oocyte and blastocyst embryos. Study group with PCOS had a statistically significant
lower fertilization rate and day-5 embryo rate of 74.8% and 54% compared with those in the control group
(84% and 61.2%, respectively). No statistically significant differences were observed in the mature oocyte
rate, the good cleavage embryo rate and the pregnancy rate in the group with PCOS compared with the
control group. Conclusion: Women with PCOS have higher number of retrieved oocytes after stimulation.
The ability to fertilization and quality of blastocyst was lower in the group with PCOS but the potential for
implantation and pregnancy rate were similar to the control group after vitrified-warmed embryo transfer.
Key words: Polycystic Ovary Syndrome (PCOS), blastocyst, in vitro fertilization, infertility
THE ROLE OF MAGNETIC RESONANCE IMAGING IN THE DIAGNOSIS AND TREATMENT ORIENTATION OF CERVICAL SPINAL STENOSIS SYNDROMES
Authors: Le Van Ngoc Cuong , Le Ngoc Quy
Published: June 2022

Objectives: To study on the magnetic resonance imaging (MRI) to diagnose the causes of cervical spinal stenosis and contribution to therapeutic orientations in cervical spinal stenosis patients. Materials and methods: Descriptive cross-sectional studies of 55 consecutive patients with cervical canal stenosis on magnetic resonance imaging in Radiology department of Hue University Hospital of Medicine and Pharmacy. Results: The mean age of the patients was 49.6 ± 11.2, and 61.8% of cases were males. Age group 40-60 was highest ratio (67.3%). The cervical spine pain was the most common symptom of cervical canal stenosis. Abnormal reflexes of upper limb tendons were one of the more common symptoms (72.7%). The combined presentation of all three syndromes: cervical spine pain, cervical root compression, and cervical cord
compression that were 54.5%. The cervical herniated disc (92.7%) is the most common cause of acquired cervical spinal stenosis. According to classical classification of cervical spinal stenosis, 52.7% of patients with absolute stenosis and 47.3% of patients with relative stenosis. According to the Kang classification in 2011, grade 1 stenosis is 50.9%, grade 2 stenosis is 36.4% and grade 3 stenosis 12.7%. Conclusion: There was a concordance between the clinical presentation and imaging manifestation of cervical canal stenosis. The concordance between the cervical canal stenosis by Kang grading system and clinical symptoms by Nurickscore were more than average with Kappa = 0.58. Therefore, it is necessary to determine the grade of injury on magnetic resonance imaging in combination with clinical symptoms to choose a reasonable treatment
method for patients with acquired cervical spinal stenosis.
Key words: Magnetic resonance imaging, cervical spine pain, cervical canal stenosis
ASSESSMENT OF THE ST-ELEVATION IN RIGHT BUNDLE BRANCH BLOCK PATIENTS COMPARED TO CORONARY ARTERY ANGIOGRAPHY
Authors: Hoang Anh Tien , Cao Thanh Truong
Published: June 2022

Background: Evaluation of patients with myocardial infarction in the setting of bundle branch block on electrocardiogram is a new approach in clinical practice. Subjects and research methods: Cross-sectional descriptive study with comparison with a control group. 67 patients with myocardial infarction (28 patients with bundle branch block and 39 patients without bundle branch block) were evaluated clinically, paraclinical, and with coronary angiography. Results: There were no statistically significant differences between the two study groups in terms of age and gender (p>0.05). The rate of patients with heart failure Killip II and above was 42.9%, much higher than the group of patients without bundle branch block (p=0.026). Complications of acute heart failure/cardiogenic shock during hospital stay were 48.4% in the group with bundle branch block, statistically significantly higher than in the group without bundle branch block (p = 0.024). The mean enddiastolic
left ventricular diameter was 53.57 ± 6.268 (p<0.01). The median Syntax score was 20.25, higher than that of the myocardial infarction group without bundle branch block (p=0.021). The ST elevation on the electrocardiogram was lower in the right bundle branch block group than in the no right bundle branch block group (p=0.021). The degree of ST segment elevation was positively correlated with Syntax I score (p < 0.01), syntax II (p < 0.05), the degree of coronary artery stenosis (p < 0.05). Conclusion: Myocardial infarction with right bundle branch block had more severe clinical and laboratory signs than myocardial infarction without bundle branch block.
Key words: ST elevation, right bundle branch block, coronary artery angiography
CURRENT STATUS OF ORAL DISEASE AMONG 3-5 YEAR-OLD CHILDREN IN SOME KINDERGARTENS IN HUE CITY IN 2019
Authors: Tran Tan Tai , Tran Thi Kim Anh , Ho Sy Minh Duc , Nguyen Thi Tan
Published: June 2022

Background: Dental caries is a common disease and is acquired very early in children after teething. Primitive teeth play an important role in chewing, so oral disease will affect the physical development of children. The objective of the study was to investigate the current status of oral disease, the role of the mother and related factors of 3-5 year-old children. Subjects and methods: A cross-sectional descriptive study of 524 children in some preschools in Hue city and their mothers. Clinical examination of the children’s oral health and interview with the mothers using to a set of questions. Results: The rate of caries in 4 schools was 70.6%, plaque was 82.3%, gingivitis was 7.3%. with p>0.05. The average index of decayed, missing, filled teeth is 3.43, 0.19; 0.97, respectively; the decayed, missing, filled teeth index (dmft) was 4.59. The group of mothers with good knowledge and practice had children with lower caries (65.8% versus 75.7%, p<0.05). Dental caries increases in group of children eating sweets by 2.29 times (OR= 2.29; p<0.01), group with habit of sucking food by 1.76 times (OR=1.76; p<0.05), children brushing teeth only in the morning or evening had risks 2.27 times higher than children with the habit of brushing teeth twice (OR=2.27; p<0.001), brushing teeth without toothpaste or with salt had caries risks 4.36 times higher (OR =4.36; p<0.001). Conclusion: The rate of dental caries in preschool children in Hue city is still quite high. It is necessary to strengthen the network of dental clinics in the community, strengthen communication and education on oral care
Key words: Oral disease, children 3-5 years old, mother’s role
USAGE OF ANTIBIOTICS IN THE INTENSIVE CARE UNIT AT HUE UNIVERSITY OF MEDICINE AND PHARMACY HOSPITAL
Authors: Le Thi Kieu Loan , Nguyen Van Dung , Ngo Thi Kim Cuc
Published: June 2022

Background: In Vietnam, a number of recent epidemiological studies demonstrated that the prevalence of antibiotic-resistant bacteria has been rapidly increasing, especially in intensive care units (ICUs). The implementation of comprehensive and long-term measures through antibiotic stewardship programs (AMS) is necessary. Objectives: For patients in the ICU of Hue University of Medicine and Pharmacy Hospital: (1) To survey of usage of antibiotics, and (2) to find out patient-related factors for antibiotic use. Materials and methods: A cross-sectional study was carried out on 102 medical records of patients who were treated in the ICU from 01/2019 to 10/2020, at Hue University of Medicine and Pharmacy Hospital. Results: The average age of patients was quite high at 70.71±19.70 years. Initial antibiotic with monotherapy accounted for 41.2%, mainly was ceftriaxone (28 prescribed), combined two antibiotics accounted for 49.0%, the most popular was the combination of third generation cephalosprins with fluoroquinolones. Most of participants prescribed a total of two or three types of antibiotics in their medical records (accounted for 68.6%). Patient-related factors associated with antibiotics usage included: antibiogram results (OR=4.7, p=0.039), sepsis diagnosis (OR=12.0, p=0.04), and initial therapeutic change (OR=14.5,
p=0.002). Conclusion: The majority of initial antibiotic therapies are monotherapy and a combination of two antibiotics in accordance with the recommendation. The number of used antibiotics were associated with the sepsis diagnosis, antibiogram results, and changing antibiotic therapy
Key words: The intensive care unit (ICU), antibiotics, antibiotic-resistant
METHOD DEVELOPMENT FOR THE DETERMINATION OF METFORMIN IN HUMAN PLASMA BY CAPILLARY ZONE ELECTROPHORESIS
Authors: Thai Thi Thu Hien , Thai Tran Minh Thi , Nguyen Van Dung , Tran Thi Tien Xinh , Thai Khoa Bao Chau
Published: June 2022

Background: Metformin is an oral antidiabetic drug from the biguanide class and it is the first-line drug chosen for the treatment of type 2 diabetes. This is a drug on the list of pharmaceutical substances required to report bioequivalence study data when registering the drug. Objectives: (1) To develope a capillary zone electrophoresis method for determining metformin hydrochloride in human plasma. (2) To validate the method. Materials and methods: Human plasma, metformin hydrochloride, ranitidine hydrochloride. The method was developed and validated according to US-FDA 2018 and EMA 2011. Results: The procedure was developed by using the Agilent 7100 CE electrophoresis system with ranitidine hydrochloride as an internal standard. Sample preparation was accomplished through protein precipitation with acetonitrile. The optimal electrophoresis conditions are as follows: uncoated fused-silica capillary column of a total length of 40 cm (31.5 cm effective length, inner diameter 100 μm), phosphate buffer solution 100 mM (pH = 4), the voltage applied to both capillary ends of 15 kV, the inlet end of capillary dipped in water before sample injection, sample injection mode of 50 mBar in 7 seconds, using a PDA detector at 232 nm. The analysis method was validated according to the requirements of the US-FDA 2018 and EMA 2011 with the following criteria: system suitability with RSD < 3%; good specificity; the calibration curves were linear (r2 ≥ 0.98) in the concentration range of 0.1 – 4.0 μg/ml for metformin in human plasma; the lower limit of quantification was 0.1 μg/ml; the intra-day and inter-day accuracy were 99.41 – 105.28% and 92.47 – 106.26%, respectively; the intra-day and inter-day precision were 1.99 – 4.03% and 3.11 – 6.05%, respectively; the mean recovery of ranitidine
(internal standard) was 86.2%, the mean recoveries of metformin at three levels LQC, MQC, and HQC were 72.9%, 75.9%, and 77.4%, respectively; plasma samples were stable to analysis. Conclusions: The developed method meets the requirements of US-FDA 2018 and EMA 2011 to determine metformin in plasma.
Key words: Capillary zone electrophoresis, plasma, metformin
TO INVESTIGATE CLINICAL MANIFESTATIONS OF TEMPOROMANDIBULAR DISORDERS IN ADULT PATIENTS AT HUE UNIVERSITY OF MEDICINE AND PHARMACY HOSPITAL
Authors: Nguyen Gia Kieu Ngan , Nguyen Huu Chung , Le Khanh Vi , Vo Duc Huy
Published: June 2022

Background: Temporomandibular disorders are relatively common disturbances in the world and Vietnam. The Diagnostic Criteria for Temporomandibular Disorders suggested by Schiffman in 2014 is a frequently used diagnostic system to classify temporomandibular disorders into subtypes, toward therapeutics purposes. Objectives: (1) To investigate clinical features of temporomandibular disorders in adult patients. (2) To classify temporomandibular disorders using the Diagnostic Criteria for Temporomandibular Disorders of Schiffman. Materials and method: Cross-sectional study in 50 adult patients with temporomandibular disorders who visited Dental Clinic, Hue University of Medicine and Pharmacy Hospital from May 2020 to May 2021. Patients were clinically examined by a calibrated doctor, using Symptoms Questionnaires and Examination Form which are the main tools of The Diagnostic Criteria for Temporomandibular Disorder. Results: The popular age group was 18-44 years old (94%). The female/male ratio was 2.8/1. Patients mostly came to the hospital due to pain (70%). Myalgia accounts for the highest proportion (70%) of all subtypes. The most common intra-articular joint disorder subtype was disc displacement with reduction (68%). Conclusions: Temporomandibular disorders were common in young, women adults; the chief complaint of patients was pain. Myalgia and disc displacement with reduction were two frequent TMD subtypes.
Key words: temporomandibular disorders, intra-articular disorders, Diagnostic criteria for Temporomandibular Disorders, disc displacement.
GÖRME ENGELLİ ÇOCUKLARIN DENGE VE YAŞAM KALİTELERİNİN İNCELENMESİ: PİLOT ÇALIŞMA
Authors: YAZICI-GÜLAY Meltem , AÇIK Cihangir , YAZICI MUTLU Çiğdem
Published: June 2022

Çalışmanın amacı görme engelli çocukların denge ve yaşam kalitelerini incelemektir. Çalışmaya 8-12 yaş arasındaki görme engelli 8, normal gören 10 çocuk dahil edildi. Çocukların yaş ve görme kayıplarının dereceleri kaydedildi, antropometrik ölçümleri alındı. Dengeleri “Denge Hata Puanlama Sistemi” ile değerlendirildi. Yaşam kaliteleri 8-12 yaş için “Pediatrik Yaşam Kalitesi Envanteri 4.0” kullanılarak değerlendirildi. Her iki grubun değerlendirmeleri Mann-Whitney U testi kullanılarak karşılaştırıldı. Tüm testlerde istatistiksel anlamlılık düzeyi 0.05 olarak kabul edildi. Her iki gruptaki çocukların yaş ve antropometrik özellikleri benzer bulundu (p>0.05). Sert/düz zemin üzerindeyken tek bacak üstünde durma, toplam sert zemin, toplam yumuşak zemin ve toplam denge hata puanlarının görme engelli çocuklarda daha yüksek olduğu bulundu (sırasıyla p=0.003; p=0.016; p=0.001; p=0.002). Çocukların yaşam kalitesi değerlendirmelerinde çocuklar arasında fark bulunmadı (p>0.05). Ebeveyn yaşam kalitesi ölçeklerinde ise fiziksel sağlık işlevselliğinde ve toplam ebeveyn değerlendirme puanlamasında görme engelli çocukların yaşam kalitesi puanlarının daha düşük olduğu bulundu (sırasıyla p=0.003; p=0.001).Görme engelli çocuklarda denge gelişimi tipik gelişen yaşıtlarına göre gecikebilmekte veya farklı şekilde ilerleyebilmektedir. Görsel bilginin denge üzerine etkisi en çok yumuşak zeminde tek ayaküstünde durma becerisinde görülmüştür. Bu durumun görme engelli çocuklar için dinamik denge becerilerinin statik denge becerilerinden daha zor olmasıyla ilişkili olduğu düşünülmektedir.
HEMŞİRELİK EĞİTİMİNDE KAVRAM HARİTASI KULLANIMININ YARATICI DÜŞÜNME EĞİLİMLERİ VE AKADEMİK ÖZ-YETERLİK DÜZEYİNE ETKİSİ
Authors: ÖKTEN Çiğdem , GÜDEK SEFEROĞLU Emine
Published: June 2022

Araştırmada, hemşirelik öğrencilerinde klinik uygulama sırasında kullanılan kavram haritası yönteminin yaratıcı düşünme eğilimleri ve akademik öz-yeterlik düzeyine etkisinin belirlenmesi amaçlanmıştır. Yarı deneysel nitelikteki bu çalışma, bir sağlık bilimleri fakültesi hemşirelik bölümü 2. sınıf öğrencilerinde Mart 2020-Mayıs 2020 tarihleri arasında yapılmıştır. Araştırma 129 öğrenci ile tamamlanmıştır. Klinik uygulama öncesi öğrencilere kavram haritası hakkında eğitim verilmiştir. Araştırma verilerin toplanmasında Tanıtıcı Bilgiler Formu, Akademik Öz-Yeterlik Ölçeği (AÖYÖ) ve Marmara Yaratıcı Düşünme Eğilimleri Ölçeği (MYDEÖ) klinik uygulama öncesi ve sonrasında uygulanmıştır. Verilerin değerlendirilmesinde Sayı ve yüzde, ortalama ve standart sapma, bağımlı gruplar t testi kullanılmıştır. Ayrıca kullanılan ölçeğin ölçüm güvenirliği için Cronbach alfa değerine bakılmıştır. Klinik uygulama sırasında vaka çalışmalarında kavram haritası yöntemi kullanılan öğrencilerde AÖYÖ toplam puan ortalaması uygulama öncesi 3.00±0.79 iken, uygulama sonrası 3.22±0.81 olduğu, uygulama sonrası toplam puan ortalamasının arttığı ve istatistiksel olarak anlamlı bir fark olduğu saptanmıştır (t=-2.222, p=0.028).MYDEÖ toplam puan ortalamalarına bakıldığında ise uygulama öncesi 3.70±0.53 iken uygulama sonrası 3.66±0.59 olduğu ve istatistiksel olarak farkın anlamlı olmadığı görülmüştür (p>0.05).Araştırmada hemşirelik öğrencilerinin klinik uygulamalarında kavram haritası kullanımının, öğrencilerin akademik öz yeterlik düzeylerini yükselttiği, ancak öğrencilerin yaratıcı düşünme eğilimlerinde anlamlı bir değişiklik oluşturmadığı tespit edilmiştir. Hemşirelik öğrencilerinin akademik öz yeterlik düzeylerinin artırılması için klinik uygulamaları sırasında vaka temelli kavram haritası kullanımı önerilebilir.
COVİD-19 PANDEMİSİ DÖNEMİNDE FİZİKSEL AKTİVİTE, DEPRESYON, BESLENME VE AĞRI ARASINDAKİ İLİŞKİ
Authors: UÇAR İlyas , KARARTI Caner , ÖZÜDOĞRU Anıl , YİNANÇ Satuk Buğrahan , GÜLER Hatice , AKTAŞ Emel
Published: June 2022

Koronavirüs Hastalığı 2019 (Covid-19) solunum yollarını etkileyen bulaşıcı bir hastalıktır. Hastalık Dünya Sağlık Örgütü (WHO) tarafından dünya genelinde salgın olarak tanımlandıktan sonra hastalığın yayılımını önlemek için sosyal izolasyonlar ve sokağa çıkma yasakları gibi tedbirler uygulanmaya başlandı. Bu tedbirler insanların fiziksel aktivite ve anksiyete düzeylerini ve beslenme alışkanlıklarını etkilemiştir. Azalan fiziksel aktivite düzeyleri, duygusal değişiklikler ve kötü beslenme alışkanlıkları algılanan ağrı düzeylerini etkileyebilecek faktörler olabilir. Çalışmamızın amacı, Covid-19 hastalığı döneminde temel yaşam tarzlarındaki değişimleri belirlemek ve algılanan ağrı düzeyi ile olan ilişkisini incelemektir. Çalışma, Google Formlar web anketini kullanan, hızlı ve geniş kesitli çevrimiçi bir anket çalışmasıdır. Çalışmamıza 18-65 yaş arası 1174 gönüllü katıldı. Ankette demografik bilgiler, fiziksel aktivite seviyelerini belirlemek için Uluslararası Fiziksel Aktivite Anketi (IPAQ), beslenme tutumlarını değerlendirmek için Sağlıklı Beslenmeye İlişkin Tutum Ölçeği, anksiyete ve depresyon seviyeleri için Hastane Anksiyete-Depresyon Ölçeği (HADS) ve algılanan ağrı seviyelerini belirlemek için Nordic Kas-İskelet Anketi (NMQ) kullanılmıştır. Yetersiz fiziksel aktivite ile boyun ağrısı (p=0,04), sırt ağrısı (p=0,048) ve bel ağrısı (p=0,034) arasında orta düzeyde bir korelasyon bulundu. Öte yandan depresyon düzeyleri ile bel ağrısı arasında zayıf bir korelasyon bulundu (p=0,049). Anksiyete ve depresyon düzeyleri ile fiziksel aktivite düzeyi (p=0,033) ve sağlıklı beslenme tutumu (p=0,041) arasında negatif korelasyon bulundu. Covid-19 salgını sırasında halkın fiziksel aktivite düzeylerinin arttırılması ve temel yaşam tarzlarındaki değişiklikler sonucu ortaya çıkabilecek kısa ve uzun vadeli olumsuz etkilerin farkında olmalarının sağlanması gerekmektedir.
COVID-19 AŞISINDA GÜNCEL UYGULAMALAR
Authors: İNCE Ufuk , SAYIN Feyza
Published: June 2022

Aşı, insanlarda hastalık yapma kabiliyeti olan bakteri, virüs gibi mikroorganizmaların patojenik özelliklerinden arındırılması veya hastalık oluşturma etkilerinin ortadan kaldırılması yöntemleri ile geliştirilen biyolojik bir üründür. Aralık 2019’da Çin’in Wuhan kentinde ilk kez ortaya çıkan koronavirüs ailesinden SARS-CoV-2, COVID-19 hastalığına neden olmuş ve bütün dünyayı etkileyerek pandemiye sebep olmuştur. SARS-CoV-2’nin oluşturduğu COVID-19 hastalığının seyrini iyileştirmek ve hastalık sebepli ölümü engellemek veya ölüm oranlarını azaltmak için aşı geliştirmek çok önemli bir amaç haline gelmiştir. Tüm dünyadaki bilim insanları pandeminin ilk aylarından itibaren aşı geliştirme çalışmalarını sürdürmekte ve günümüzde de halen sürmekte olan pandemiye karşı farklı metotlarla geliştirilen aşılar uygulanmaya başlanmıştır.
Effect of distinct nitrate concentrations on pigment content of mixed culture of Chlorella vulgaris and Dunaliella sp.
Authors: Putri Rahayu Dian Eka , Pradana Yano Surya , Koerniawan Mochamad Donny , Suwanti Lucia Tri , Siregar Ulfah Juniarti , Budiman Arief , Suyono Eko Agus
Published: June 2022

Chlorella vulgaris and Dunaliella sp. are prominent microalgae that are generally used for natural pigment stocks. These species have been established as producer of valuable bio compounds such as chlorophyll, carotenoids, and astaxanthin. For this research, C. vulgaris and Dunaliella sp. were cultivated in mixed culture under nitrogen stress treatments. Total four treatments at distinct nitrate concentrations of 0.012, 0.025, 0.5 NaNO3 g/L, respectively including nitrogen starvation was incorporated in this study. Nitrogen limitation and nitrogen starvation are widely used techniques to manipulate metabolic pathways into secondary pigments biosynthesis in microalgae cells. In addition, spectrophotometric measurement was conducted to investigate every single pigment content in all four treatments of distinct nitrogen concentrations for 14 days. The highest chlorophyll-a (23.65 mg/L), chlorophyll-b (10.02 mg/L), and total carotenoids (7.61 mg/L) were obtained from mixed culture with a concentration of 0.025 g/L NaNO3 in the last period cultivation. Conversely, the highest content of astaxanthin (0.6 mg/L) in mixed culture of C. vulgaris and Dunaliella sp. in the last period cultivation was achieved from starvation of nitrogen as well. The microalgae demonstrated robust growth in the presence of diverse bacterial community in the culture. It is well known that microalgae are associated with the microbiota on its phycosphere biofilm. Yet, it is unclear which specific bacteria taxa have a role in supporting or inhibiting microalgae growth.
excrecencia de lo arbitrario en las prácticas sanitarias durante el Coronavirus con la población envejecida
Authors: Klein Alejandro
Published: June 2022

Este trabajo busca ser un sumario analítico y crítico de las publicaciones 2020-2021 enfocadas al tema de la tercera edad, coronavirus y políticas sanitarias. A partir del análisis de las mismas se postula el surgimiento de un “edadismo sanitario”, por el cual, a nombre del “cuidado” se ha confinado y encerrado a los adultos mayores, indicando que las decisiones sanitarias tomadas han implicado un nuevo retroceso de la imagen del adulto mayor a lo vetusto, lo decrépito, en una fantástica resurrección del paradigma de la vulnerabilidad en la tercera edad.
contribución completa del cuerpo al totalitarismo cubano. Entre microfísica y microhistoria
Authors: Espinosa Eduardo Luis
Published: June 2022

La microhistoria italiana de Carlo Ginzburg y la microfísica del poder elaborada por Michel Foucault, nos permiten explicar la dominación del cuerpo en el totalitarismo cubano. Así lo podemos ubicar en los micropoderes y las tecnologías políticas del cuerpo. Conforme al paradigma indiciario, son los datos del cubano de la calle y su cotidianidad los que nos ayudan a entender que el Estado llega a un dominio completo del cuerpo, a una contribución completa de las energías de sus ciudadanos. Históricamente, ellos cedieron sus bases de poder independiente en favor del proceso de centralización y militarización del Estado a partir de 1959. Paradójicamente, ese proceso tuvo antecedentes en la época que se luchaba por darle validez a la Constitución de 1940 -vanguardia de la democracia en el hemisferio occidental..
3, 2, 1 ¡jugger!
Authors:   , Sangiao Gisela Soledad
Published: June 2022

La siguiente tesis se inscribe en el área de los estudios socioculturales vinculados a las problemáticas de las prácticas corporales en espacios urbanos. La misma gira en torno a dos ejes principales: una práctica corporal -el jugger- y un espacio urbano -el parque Saavedra de la ciudad de La Plata, capital de la provincia de Buenos Aires, Argentina-. El jugger es una práctica corporal de origen reciente, frecuentemente denominada deporte alternativo, que se desarrolla exclusivamente en parques de la ciudad y que tiene como protagonistas a grupos de jóvenes. El parque Saavedra, por su parte, es uno de los tantos espacios verdes públicos de La Plata, una ciudad paradigma diseñada bajo teorías higienistas y racionalistas decimonónicas. A partir de una metodología cualitativa y desde un enfoque etnográfico, la investigación de la cual se desprende este documento busca interpretar los modos de uso y apropiación que los jóvenes practicantes de jugger hacen del parque Saavedra. Se procura así reponer la perspectiva de los jugadores, a fin de comprender los sentidos que le confieren a su práctica -en este caso, una no convencional, emergente y potencialmente contestataria de las lógicas del deporte hegemónico- y al espacio en que la llevan a cabo, entendiendo que el espacio y las prácticas constituyen un par indisociable signado por un vínculo de producción recíproca.
РОЗВИТОК SOFT SKILLS ЗАСОБАМИ ІНТЕРАКТИВНИХ ТЕХНОЛОГІЙ (ПІДРУЧНИКІВ) НА ЗАНЯТТЯХ З ІНОЗЕМНОЇ МОВИ У ЗАКЛАДАХ ВИЩОЇ ОСВІТИ
Authors: Триндюк Валентина , Мартинюк Алла , Губіна Алла
Published: June 2022

У статті йдеться про розвиток «м’яких» навичок на заняттях з іноземної мови. З’ясовано, що «м’які» навички – це комплекс особистісних та міжособистісних вмінь, необхідних для вирішення професійних та загальних завдань задля успішного існування в суспільстві. Нині не існує єдиної думки щодо класифікації «м’яких» навичок. У 2022 році найпопулярнішими «soft skills» вважаються навички спрямовані на: вирішення проблем; самоуправління; роботу з людьми; використання та розвиток технологій. Ефективною технологією для розвитку «м’яких» навичок на занятті з іноземної мови є інтерактивна модель навчання - організоване викладачем освітнє середовище для комфортної інтеракції зі студентами з метою активізації розумової діяльності та досягнення мети заняття. Така модель навчання передбачає використання інтерактивних підручників. Встановлено, що вправи інтерактивних підручників відповідають класифікації інтерактивних технологій: діалогічні, дискусійні, ігрові, тренінгові, вправи з аналізу ситуацій, що відтворюють реальні життєві ситуації. Такі завдання розвивають критичне та аналітичне мислення, творчість, ініціативність, навички спілкування; навчають формулювати, аргументувати та відстоювати власну позицію тощо. У статті доведено, що інтерактивні підручники є ефективними засобами, які забезпечують формування на занятті з іноземної мови необхідних сучасному фахівцеві «м’яких» навичок в умовах дистанційного навчання зокрема.
ESTABLISHMENT AND CALIBRATION OF DISCRETE ELEMENT MODEL OF KING GRASS STALK BASED ON THROWING TEST
Authors: HUAN Xiaolong , WANG Decheng , MA Wenpeng , ZHU Lu , LI Sibiao
Published: June 2022

In order to better use the discrete element method (DEM) to study the cutting and throwing process of King Grass (KG) stalk in mechanical harvesting, the DEM model and contact parameters of KG stalk were studied in this paper. By using the Multi-sphere method, the DEM model of KG stalk was established in EDEM software. Through the impact bounce test and slope sliding test, the stalk-steel coefficient of static friction, stalk-steel coefficient of restitution and stalk-stalk coefficient of restitution were calibrated as 0.372, 0.656 and 0.523, respectively. Based on the stacking test, using the response surface methodology, the optimal values of stalk-stalk coefficient of static friction, stalk-stalk coefficient of rolling friction, stalk-steel coefficient of rolling friction were calibrated as 0.393, 0.072 and 0.144, respectively. The throwing test bench of stalk was designed, and the actual and simulation throwing test were carried out. The relative error of throwing distance in bench test and simulation test under four throwing speeds was 1.15%, 7.76%, 8.88% and 10.46%, respectively. The throwing trajectory curve of the simulation test is consistent with that of the actual test, which verifies the accuracy of the DEM model and contact parameters of KG stalk.
A study on the effect of bacteriocin production from lactic acid bacteria in poultry nutrition
Authors: Marian N Unachukwu , Chukwuebuka Onyia Felix , Chijioke Onwujekwe Emmanuel , Stanley Chijioke Eluu , Onyinye O. Amobi
Published: June 2022

Objective: This research was carried out to isolate lactic acid bacteria from dairy products, to examine the isolated lactic acid bacteria for the production of bacteriocin, its purification as well as its use as supplement in poultry nutrition to improve the growth performance of the birds. Methodology and results: Five (5) samples of cow milk and five (5) samples of fresh yoghurt were procured from the market; each sample was serially diluted to the third fold and plated on De Man Rogosa Sharpe agar (MRS) agar. Pure discrete colonies of Lactobacillus spp were isolated and sub-cultured on MRS broth. Lactobacillus spp isolated from Cow Milk and Fresh Yoghurt was screened using agar well diffusion. Lactobacillus isolates which showed high zone of inhibition against the test organisms (Staphylococcus aureus and Escherichia coli) were designated positive. These isolates were centrifuged at 20,000 rpm (≤40C) for 30 min and their supernatant was adjusted to pH of 7.1 with Na2CO3 to remove lactic acid effect, before filter sterilization using membrane filter (0.2μm). Five (5) mg/ml catalase was added to eliminate peroxides effect. The solution was tagged as bacteriocin crude extract (BCE) which was infused into the poultry feed. Ten (10) three weeks old chicks were separated into two groups (5 each). “Group A” as the control and “Group B” as test. The test chicks had 5ml of bacteriocin infused into their daily feed while the control chicks were fed without any infusion of bacteriocin in their feed. The chicks were weighed every seven (7) days to compare the weight gain between the control and test chicks. At the end of the study, it was found that the test chicks weighed 900g when compared to the control chicks, which weighed 830g. Conclusion and application of results: This therefore means that bacteriocin produced by lactic acid bacteria aids in the weight gain of poultry. This suggests that bacteriocin could be considered a major growth booster in poultry feed and should be applied in its feed formulation. Keywords: Bacteriocin, Cow milk, Fresh yoghurt, Lactic Acid Bacteria, Lactobacillus
Pengaruh Pengetahuan terhadap Peran Mahasiswa dalam Pencegahan Covid-19
Authors: Hidayat Anas Rahmad , Hayati Isnani Nur , Yuniarti Tri , Nuryanti Dina Dwi , Ernawati Ernawati
Published: June 2022

Covid-19 merupakan penyakit menular melalui pernafasan yang disebabkan oleh Corona Virus serta ditemukan pertama kali di Wuhan, Hubei, Cina pada bulan Desember 2019. Pada bulan Januari 2020 Covid-19 menyebar ke 19 negara sejumlah 11.791 kasus, dengan 213 kematian. Indonesia melakukan upaya memutus mata rantai penularan virus, salah satunya dengan melibatkan peran serta masyarakat. Mahasiswa merupakan bagian dari masyarakat yang memiliki pengetahuan dan pendidikan. Mahasiswa yang memiliki kreativitas yang tinggi, optimis, dan memiliki kemampuan adaptif (fleksibel), dapat mengambil peran dalam mencegah penularan Covid-19. Tujuan penelitian untuk mengetahui pengaruh pengetahuan terhadap peran mahasiswa dalam pencegahan Covid19. Desain penelitian yaitu deskriptif analitik. Besar sampel 528 mahasiswa kesehatan, dengan teknik pengambilan sampel menggunakan purposive random sampling. Metode pengumpulan data menggunakan survei dilakukan pada bulan Juni 2020. Alat pengumpulan data menggunakan kuesioner dan didistribusikan secara random menggunakan google form. Analisis data menggunakan Regresi Linier dengan signifikansi 5%. Hasil penelitian didapatkan ada pengaruh pengetahuan terhadap peran mahasiswa dalam pencegahan Covid-19 dengan p-value: 0.0001 < 0.05. Peran mahasiswa meliputi pembagian masker (42.4%), edukasi melalui media sosial (68,4%), menjadi relawan (7%) dan penggunaan desinfektan untuk mencuci tangan dan alat rumah tangga. Mahasiswa memiliki kontribusi besar dalam upaya pencegahan Covid-19 melalui edukasi di media sosial sehingga, peran ini diharapkan berkelanjutan meskipun masa pandemi telah usai.
Pengembangan Video Animasi Berbasis Kearifan Lokal Sebagai Media Promosi Kesehatan Manfaat Buah dan Sayur
Authors: Awuni Nur Syamsiah , Isni Khoiriyah
Published: June 2022

Rendahnya tingkat konsumsi buah dan dayur pada anak di wilayah Kabupaten Klaten masih menjadi masalah gizi yang harus segera diatasi. Salah satu upaya yang dilakukan adalah penggunaan media promosi kesehatan. Namun, media tersebut belum efektif dikarenakan penggunaan Bahasa yang tidak sesuai dengan Bahasa yang digunakan sehari-hari oleh anak. Oleh karena itu, diperlukan suatu kajian pengembangan media promosi kesehatan yang bebasis kearifan lokal untuk mengatasi masalah tersebut. Jenis penelitian yang dilakukan merupakan penelitian dan pengembangan (Research and Development) level 1. Penelitian ini diawali oleh penggalian potensi masalah dengan sasaran anak dan orang tua. Selanjutnya, dilakukan pengembangan media promosi kesehatan yang tervalidasi oleh ahli media dan ahli materi, serta ahli Bahasa. Hasil penelitian menunjukkan adanya kebutuhan edukasi manfaat buah dan sayur bagi anak dengan menggunakan Bahasa Jawa berupa video animasi. Sementara itu, hasil pengembangan berdasarkan penilaian dari ketiga ahli dinyatakan sangat layak. Media promosi kesehatan ini perlu dilakukan uji coba pada sasaran terbatas hingga luas agar dapat digunakan sebagai media promosi kesehatan yang valid untuk penanggulangan rendahnya konsumsi buah dan sayur pada anak.
Analisis Kadar Vitamin C Wedang Jeruk Nipis (Citrus Aurantifolia) Berdasarkan Variasi Suhu Menggunakan Metode Spektrofotometri Uv – Vis
Authors: Yulianto Susilo , Jamilatun Makhabbah , Jamilatun Makhabbah , Pangesti Feby Ari , Pangesti Feby Ari
Published: June 2022

Vitamin C merupakan salah satu vitamin yang mudah larut dalam air.dan mudah mengalami kerusakan oleh reaksi oksidasi. Suhu sangat berpengaruh terhadap penurunan kadar vitamin C. Salah satu  buah yang mengandung vitamin C yaitu buah jeruk nipis. Jeruk Nipis dapat dibuat beberapa minuman salah satunya wedang jeruk nipis dengan berbagai variasi cara pembuatan yaitu dibuat dengan suhu dingin, ruang, hangat, dan panas.  Pada umumnya masyarakat tidak menyadari bahwa minuman yang mengandung vitamin C membutuhkan suhu yang tepat agar kandungan kadar vitamin C tetap utuh saat dikonsumsi Tujuannya yaitu untuk mengentahui kadar vitamin C dalam wedang jeruk nipis dan menganalisis perbedaan kadar vitamin C dalam wedang Jeuk nipis. Wedang jeruk nipis dibuat 4 formula variasi suhu yaitu suhu dingin, ruang, hangat dan panas. Jenis penelitian ini adalah penelitian kuantitatif. Parameter yang diamati dalam penelitian ini adalah kadar vitamin C. Kadar vitamin C dianalisis menggunakan metode Spektrofotometri uv-vis pada Panjang gelombang 262 nm. Kadar vitamin C tertinggi pada suhu dingin sebesar 0,07096%, suhu ruang yaitu sebesar 0,06328%, suhu hangat yaitu sebesar 0,05116%, dan air panas yaitu sebesar 0,02740%. Data yang diperoleh dianalisis dengan uji anova satu arah. Hasil penelitian menunjukkan bahwa terdapat perbedaan yang signifikan terhadap kadar vitamin C pada wedang jeruk nipis dalam variasi suhu.
Pendidikan Islam di Indonesia (Kajian Upaya Pemberdayaan Dan Rekonstruksi)
Authors: Arief Mohammad
Published: June 2022

Problem utama dalam pendidikan Islam yang sering terjadi adalah berkaitan dengan pemberdayaan sumberdaya manusia dan rekontruksi sistem pendidikan tersebut yang sering tumpang tindih antar satu sistem dengan sistem yang lain. Pada titik inilah dikotomi terjadi akibat kesalahan ketika melakukan rekontruksi tersebut. Pendidikan Islam menjadi sarana dalam mentransferkan nilai-nilai ke-islaman itu sendiri kepada generasi selanjutnya. Hal ini diharapkan bisa membentuk sebuah peradaban bangsa yang unggul dengan ilmu pengetahuan dan teknologi yang berasakan Al Qur’an dan hadits sehingga mampu menjawab tantangan jaman. Namun hal itu urung terwujud dikarenakan beberapa permasalahan yang dihadapi, diantaranya lemahnya manajemen dan dikotomis system Pendidikan di Indonesia. Pemberdayaan dan rekonstruksi system Pendidikan Islam diharapkan mampu mewujudkan tujuan Pendidikan Islam yang sebenarnya yang akan membawa umatnya Bahagia di dunia dan akhirat. Tidak hanya itu, juga dapat mengurai dikotomi sehingga tidak ada yang bertentangan dan tumpang-tindih satu dengan yang lain, baik dari pemberdayaan dan rekontruksi pengetahuan sehingga mampu menjadi pendidikan yang berdaya saing global
The Relevance of Al-Ghazali and Ibn-Khaldun's Education Concepts in Era 4.0.
Authors: Saputra Hardika , Kurniawan Dwi , Fentari Retno
Published: June 2022

The purpose of this study is to explore the meaning of the thoughts of Al-Ghazali and Ibn Khaldun and the relevance of these two thoughts during the industrial revolution 4.0. This research uses library research method with data collection techniques sourced from written texts which are then analyzed using content analysis techniques. The concept of education in Islam is not only a question of how to instill values to defend oneself from the influence of life in the Industrial Revolution era. However, the most important thing is how the moral values that will be instilled can solve problems in human life, such as ignorance, poverty, and backwardness in various fields. This proves that Islamic education has an important role in the process of forming human beings who are cognitively intelligent but also have a good personality and the application of Islamic teachings in life. This research contributes to the study of Islamic thinkers and the contribution of their thoughts in the era of the industrial revolution 4.0
Learning Strategy for Islamic Religious Education During the COVID-19 Epidemic
Authors: Sunhaji Sunhaji
Published: June 2022

Countries all around the world, including Indonesia, are being affected by the COVID-19 epidemic at the moment. As a result of the numerous issues that arose as a direct result of the pandemic, including those that occurred in the field of education, all of the educational pursuits, including teaching and learning, were moved online in order to reduce the risk of the virus spreading further. Learning in Islamic Religious Education encompasses individuals who contend with obstacles, primarily for the purpose of imparting a grasp of the subject matter to students through activities outside of the traditional classroom setting. The purpose of this research is to identify the most effective method for studying Islam in the midst of the COVID-19 pandemic as it exists today. In this investigation, a qualitative strategy is combined with a descriptive research approach. According to the findings, during the COVID-19 epidemic, the most common mode of instruction for Islamic theological and philosophical topics was online study. During the COVID-19 period, the strategies for learning Islamic religious education that were utilized include effective time management, preparation of media and technology, directing and motivating students to study seriously, maintaining discipline, and always maintaining communication with students.
Predictors of BMI and WHR among Malaysians of Different Cultural Background
Authors: Botabara-Yap Mary Mary
Published: June 2022

The epidemic of overweight and obesity is encroaching in the world today, irrespective of economic and social status and regions. It is now seen as a public health threat and one that must be taken seriously in all aspects of public health interventions. This study investigates the predictors of overweight and obesity, as measured by body mass index (BMI) and waist-to-hip ratio (WHR) among Malaysians. A questionnaire survey was conducted among 459 samples from those who attended a health screening drive, conducted in three major regions in Peninsular Malaysia. Data were analyzed using descriptive statistics such as mean and standard deviation as well as multiple regression, with p <0.05 considered significant. Results showed that 56% of the respondents were overweight, the prevalence was highest among Indians (24.6%, 95% CI=20.3, 29.3), followed by Malays (23.2%, 95% CI=21.6, 24.8%) while the lowest prevalence was among the Chinese respondents (8.2%, 95% CI=6.2, 10.6).  Smoking (p value of .000) and physical activity (p value of .023) were predictors for BMI while smoking (p value of .000) was a predictor of WHR. Findings showed that the problem of overweight and obesity in Malaysia is real and smoking and physical activity play a strong role and need to be considered in any public health interventions.