bluuebunny/crossref_metadata_2025 huggingface dataset:
USULAN SISTEM PERANCANGAN KERJA PADA DEPARTEMEN GA DI PABRIK SEPATU
Authors: Novarina Ika , Rini Asih Setyo , Hanan Siti
Published: April 2024

This study aims to provide suggestions for improvements to increase work productivity in the Dept. GA on shoes factory. Subjective complaint experienced by workers along with ergonomic measurements that have haven’t carried out according to regulations. The proposed work design according to ergonomic principles is expected to reduce workers' complaints of subjectivity. Ergonomics is an effort to harmonize tools, work methods and work environment for humans with all their limitations so as to obtain optimal results. The study was conducted on the entire employee population by measuring the level of subjectivity complaints using the Nordic Body Map. REBA measurements are carried out to find out the work posture that needs to be improved. The design of the proposed work system is carried out using the Participatory Ergonomic method. The results of this study the authors propose an adjustable platform of a hydraulic scissor lift, a swing model and placement of employees with a maximum age of 35 years old. These three suggestions can reduce subjective complaints by eliminating awkward movements and preventing muscle mass decreasing for workers aged over 35 years
PENGENDALIAN KUALITAS PRODUK HPL MENGGUNAKAN METODE SIX SIGMA DAN FAILURE MODE AND EFFECT ANALYSIS UNTUK MENGURANGI CACAT DI PT TACO ANUGRAH CORPORINDO
Authors: Sukmawati Sri , Khaerudin Dedy , Sholikah Annisa Wakhidathus
Published: April 2024

The competition in the manufacturing industry in Indonesia is getting tighter, thus encouraging the industry to compete to improve the quality of its products. PT Taco Anugrah Corporindo is one of the manufacturing industries that produces HPL (High Pressure Laminate). In the production process, HPL produces several types of defects, the average for each type of defect still exceeds the KPI (Key Performance Indicator) set by the company. PT Taco Anugrah Corporindo wants the level of defects to be within the KPI range that has been set by identifying problems and repairing them. The purpose of this study is to reduce the number of defects. Six Sigma with the DMAIC method as a quality improvement to achieve the target of 3.4 failures per one million opportunities (DPMO). Using FMEA to Analysis the causes of the problem and recommendations for improvements. The results of this study found six types of potential CTQ, that is 71% PM, 11% PMLP, 7% BH, 5% DP, 4% Overlay and 3% TMB. The average calculation of the DPMO and Sigma Level values is 4,465 which is still far from 6 sigma. The causes of defects in products are caused by several factors such as humans, machines, methods, materials, and the environment. As for recommendations for improvement that can be given are the preparation of SOP and IK, training for operators, adjusting the machine by installing grounding and anti-static, monitoring work methods and maintaining the workplace.
ANALISA RESIKO KESELAMATAN KERJA KARYAWAN PRODUKSI SEPATU DIVISI NIKE DENGAN METODE HIRARC (HAZARD IDENTIFICATION, RISK ASSESSMENT, AND RISK CONTROL) DI PT. NIKOMAS GEMILANG
Authors: Widianto Yopie , Budiharjo Budiharjo , Ramadhania Sherin
Published: April 2024

Occupational Safety and Health (K3) is an issue that must be considered by all organizations, for example in industry. Based on observations and interviews of the production department at the Nike Division of PT. Nikomas Gemilang, There have been work accidents ranging from light to severe categories.
The Hazard Identification, Risk Assessment and Risk Control (HIRARC) method in the production process with hazard identification steps (Hazard Identification), risk assessment (Risk Assessment) classifies based on the severity of the hazard posed (Severity). The last step is to multiply the Likelihood value and Severity value that will be mapped into the Risk Matrix.
Hazard identification using Job Safety Analysis (JSA) 33 potential hazards were obtained in the production section at PT. Nikomas Resplendent Nike Division. There are 3 types of hazards that exist in the entire production process, namely: ergonomic hazards, physical hazards and chemical hazards. From the results of the risk assessment, it was found that the risk in the Low category was 11 (34%) potential, while in the Medium category there were 10 (30%) potentials, the High category as many as 8 (24%) potentials and the Very High category 4 (12%) potentials.
Control that can be done to reduce risk is the use of Personal Protective Equipment (PPE) for workers, so that workers can safely and comfortably work and are installed warning signs in every corner of the room to prevent accidents
PENERAPAN FRAMEWORK CODEIGNITER 4 DALAM APLIKASI PENJUALAN PAKAIAN BERBASIS WEB PADA DISTRO DISTROBUTOR
Authors: Auliana Sigit , Permana Basuki Rakhim Setya , Qozzo Kevin Pedro , Kurniawanto Hadi
Published: April 2024

In the rapidly evolving digital era, distribution businesses require an efficient and integrated sales information system to enhance operational performance and customer service. This research aims to implement a web-based shirt sales information system using the CodeIgniter 4 framework for distro distrobutor. The research methodology encompasses stages of needs analysis, system design, implementation using CodeIgniter 4, and application testing. The needs analysis process is conducted to understand user requirements and the business characteristics of distribution distributors. Meanwhile, system design involves database design, user interface, and application architecture. Implementation utilizes the outstanding features of CodeIgniter 4 to construct a responsive and easily manageable sales application.
The anticipated outcome of this research is expected to provide a positive contribution to improving the efficiency of clothing sales in distribution distributors. With the adoption of the CodeIgniter 4 framework, it is hoped that the system can deliver an optimal user experience and support the daily operations of distro distrobutor. Additionally, this research is expected to serve as a reference for developers and business owners in adopting information technology on a broader scale in the clothing distribution industry
PEMBANGUNAN VIRTUAL MUSEUM BERBASIS VIRTUAL REALITY PADA UPTD TAMAN BUDAYA MUSEUM NEGERI BANTEN
Authors: Permana Basuki Rakhim Setya , Auliana Sigit , Rosid Ahmad Jumhadi
Published: April 2024

The Banten Provincial State Museum is located in the historic Pendopo Gubernur Banten building in the city of Serang. The building was formerly the Banten Residency Office, established on January 26, 1821. On October 29, 2015, Governor Rano Karno officially inaugurated the museum. The primary goal of the Banten Provincial State Museum is to serve as a repository for the identity of the Banten region. The museum's collection includes historical artifacts from Banten as well as contemporary items from the region. In an effort to enhance accessibility, a Virtual Museum Website was created, allowing visitors to explore the collection anytime and anywhere.
The Banten State Culture Park and Museum Unit, responsible for the museum's collections, deeply understands the importance of quality and comfort for visitors. Therefore, the museum not only keeps up with developments in the era of digitalization but also utilizes visualization and simulation technologies, including Virtual Reality. The use of this technology is expected to facilitate visitors in accessing the museum's collection through their electronic devices. The museum recognizes that the development of visualization technology, especially in Virtual Reality, has made significant progress in terms of output quality (graphics, sound, touch), user-friendliness, equipment efficiency, and psychological aspects.
This research employs the Research and Development (R&D) method with a Waterfall approach for its development. Data collection techniques include interviews, observations, and literature reviews. With the implementation of the designed website, it is hoped that visitors can easily access the prehistoric collection without physically visiting the museum
KONSEP KOMUNIKASI DALAM DUNIA PENDIDIKAN
Authors: Dahrial Dahrial , Iskandar Iskandar , Suhardi Suhardi
Published: April 2024

Communication can occur with anyone, anywhere, and at any time. Since birth, humans have carried out communication activities. This is proven by the crying of every newborn baby. Crying is the only way for babies to communicate with the people around them, this refers to the words of Allah in surah Ar Rahman (1-4) Allah is the most merciful, who has taught the Qur'an, he created humans, taught them to speak. As humans grow, communication will continue to occur until a human finally dies. Communication is the process of conveying or receiving messages from one person to another, either directly or indirectly, orally, in writing, or by using signs. Communication in education is a very important element, in fact it plays a very big role in determining the success of an education. Many people say that the level of achievement of educational quality is influenced by communication factors
IMPLIMENTASI PEMBELAJARAN IPAS BERDASARKAN ASAS KI HAJAR DEWANTARA DALAM KERANGKA KURIKULUM MERDEKA: STUDI KASUS DI SEKOLAH DASAR
Authors: Prasetyo Hermawan , Roemintoyo Roemintoyo , Sukarno Sukarno
Published: April 2024

It is known that the curriculum is an important basis for teachers to use as a reference for carrying out learning activities. Therefore, this research aims to describe the implementation of science and science learning in elementary schools that implement the Merdeka curriculum. This research method is a qualitative descriptive method. The research subjects consisted of 2 elementary school teachers. Data collection techniques consist of interviews and observations followed by instruments, namely a list of questions and observation sheets. The data analysis technique uses descriptive data by providing a general description of the research findings. The results of this research show that during the science and science learning activities, the teachers have implemented and are committed to the implementation of the independent curriculum, so that they apply innovative learning models and strategies. On the other hand, it can be seen that after analyzing the research findings, it shows that the implementation of ongoing learning is based on the principles of education according to Ki Hajar Dewantara. Therefore, the application of this independent curriculum should be widely applicable and implementable for various types of subjects in elementary schools in particular
PEMBUATAN MEDIA PEMBELAJARAN FISIKA BERBASIS KEARIFAN LOKAL MENGGUNAKAN THUNKABLE
Authors: Khotimah Kusnul , Hidayanto Taufik , Ummah Syifa Auladi El
Published: April 2024

This research aims to: (1) determine the creation and results of making Physics learning media based on local wisdom using thunkable. (2) find out the results of the assessment of local wisdom-based Physics learning media using thunkable. This type of research is research and development, R & D (Research and Development) using the ADDIE model. The procedure for making learning media consists of several stages, namely: (1) the preparation stage, namely by carrying out initial design planning, preparing concepts for learning media for measurement material. (2) the creation stage, namely the creation of a mobile application using Thunkable based on local wisdom, and (3) the completion stage, namely the assessment of Physics learning media based on local wisdom. Based on the creation of learning media and the discussions that have been carried out, it can be concluded that: (1) the creation of Physics learning media based on Local Wisdom consists of 3 process stages (preparation, creation and completion), this media has a display such as the start page, login page, menu page, instructions page, materials page, practice questions page, simulation page, and evaluation page (2) Local Wisdom-based learning media has met the very good criteria with a score of 49 out of a maximum score of 50 for the media aspect and 57 out of a maximum score of 60 for material aspects
THE INFLUENCE OF EMOTIONAL INTELLIGENCE ON ENGLISH LEARNING OUTCOMES OF CLASS XI STUDENTS MA. MURSYIDUTTHULLAB LEMBANNA
Authors: Rahmi Rahmi , Irfayani Irfayani
Published: April 2024

This study aims to determine the significance of the influence of emotional intelligence on the results of learning English for class XI, MA. Murshidutthullab Lembanna. The method used in this research is a quantitative method. The results of the study are simple linear regression equations. In the analysis that has been carried out on the basis of decision-making, "If Tcount is greater than Ttable," then H0 is rejected, and Ha is accepted. This shows that tHitung  is 25.465 > ttable is 1.691, so it can be interpreted that there is a significant influence on emotional intelligence on English learning outcomes. In addition, if seen in the correlation coefficient of 0.654, the coefficient of determination (R squared) is 0.428, or 42.8%, and the rest is influenced by several factors that were not carried out in this study, namely 57.2%. So it can be interpreted that there is a positive and significant influence of emotional intelligence on the results of learning English for  students in class XI. MA. Murshidutthullab lembanna
MANAJEMEN PEGAWAI PEMERINTAH DENGAN PERJANJIAN KERJA (PPPK): SEBUAH ALTERNATIF KEPEGAWAIAN BARU SELAIN PNS
Authors: Samsara Ladiatno , Firmansyah Nurhuda
Published: April 2024

Pegawai Pemerintah dengan Perjanjian Kerja (PPPK) are one type of staffing in government agencies. PPPK is based on specific competencies and skills, so a PPPK is an employee ready to work immediately. PPPK is managed by Government Regulation No. 49 of 2018 concerning PPPK Management. Since its issuance in 2018, Government Regulation No. 49 of 2018 concerning PPPK Management has yet to be fully implemented. This is because several derivative regulations from Government Regulation No. 49 of 2018 concerning PPPK Management still need to be made available. In addition, the PPPK recruitment process is still based on transferring contract workers to become PPPK. This study aims to describe PPPK management based on the perspective of the laws governing it and its implementation and the differences and similarities with the management of Civil Servants. The methodology used is descriptive qualitative with literature studies on laws and regulations, publication of journals or books with the theme of Human Resource Management (MSDM) and Government Employees with Employment Agreements (PPPK). Based on an analysis of several documents, the derivative policy of Government Regulation No. 49 of 2018 concerning PPPK Management has yet to be fully available. One of them is related to the termination of the employment agreement. In addition, the implementation of PPPK recruitment is still very much focused on transferring contract workers to PPPK. Thus, not all of the technical regulations related to PPPK can be implemented ideally. One of them is related to the need for competency development
EFEKTIFITAS IMPLEMENTASI EDU-GAME UNTUK MENINGKATKAN KESADARAN PERILAKU BUANG SAMPAH PADA TEMPATNYA
Authors: Dayurni Popi , Umalihayati Umalihayati , Rini Ratu Yustika
Published: April 2024

The waste problem in Indonesia is quite complex due to the lack of public understanding of the consequences that waste can cause. Apart from that, there is a mismatch between people's standard of living and knowledge about waste and a lack of community participation in maintaining cleanliness by disposing of waste in its proper place. One of the villages that is quite bad in terms of waste regulations is Panenjoan Carenang Village where rubbish is simply piled up in every corner of the village. This is due to a lack of awareness regarding the behavior of throwing rubbish in its place. Understanding regarding the behavior of throwing rubbish in its place should be instilled from a young age. Children need to be given an understanding of the negative impacts of throwing away rubbish to increase awareness of throwing rubbish in its proper place. To provide understanding to children, media is needed. One of the learning media that provides concrete experiences is game media. So there needs to be an educational game media (edu-game) to introduce the bad effects of throwing away rubbish to children. The aim of this research is to determine the effectiveness of implementing edu-games to increase the behavior of throwing rubbish in its place. The research method used is quantitative. The research results show that tcount > ttable (3,871 > 16,039), and the significance value (P) is 0.000 < ???? (0.05), thus Ho is rejected and Ha is accepted. This proves that the implementation of edu-games can increase awareness of disposing of waste in its place
MAKNA EMPAT PILAR LITERASI DIGITAL DAN POTENSINYA MENEKAN PEREDARAN HOAX DI RUANG DIGITAL INDONESIA
Authors: Azanda Siti Hanifa , Syah Robby Firman , Ayunda Winda Anestya
Published: April 2024

This study reviews the meaning of digital literacy which is a national program initiated by Ministry of Communications and Informatics (Kominfo). There is so much information content that is easily accessible to the public in the digital space, making the government through Ministry of Communications and Informatics launch a national digital literacy program since 2020. This program takes the form of training in basic digital literacy skills, namely digital skills; digital ethics; digital culture; and digital security. However, since the beginning of its implementation, there have been challenges that have caused the program's achievements to not be optimal. This study uses a descriptive qualitative approach by collecting data through interviews, focus group discussions (FGD), and literature studies. The results of this study show that people's understanding of the meaning of the four pillars of digital literacy is not yet optimal. Increasing digital literacy outreach and training targeting the right participants can maximize more positive use of digital space
STREAMING MUSIK SEBAGAI KONSTRUKSI IDENTITAS (SEBUAH KAJIAN LITERATUR)
Authors: Nugraha Aji Satria , Komariah Siti , Nurbayani Siti
Published: April 2024

In the current digital era, it is incredibly simple to appreciate music. It is now possible to enjoy music without purchasing CDs, cassettes, or even black plates. The availability of music streaming services has rendered internet connectivity the sole requirement for unrestricted music listening. Thus, music can be utilised to accompany daily activities as background music. Prior studies have indicated that an individual's identity might be discernible through the music collection hosted on a music streaming platform. This literary study aims to investigate the process of identity formation through music streaming services, drawing on past research and the social construction theory proposed by Peter L. Berger and Thomas Luckmann. Internalisation, externalisation, and objectivation are the three dialectical moments of social construction that occur during the identity formation process via the music streaming service, according to this literary analysis. The moments of introspection an individual experiences while listening to music on a personalised streaming service are compiled into a playlist that contributes to the formation of one's sense of self. When identical identities are present in a society, objectivation ensues, resulting in the formation of a new social identity
KESEJAHTERAAN PSIKOLOGIS PADA PERAWAT: HUBUNGANNYA DENGAN KEPRIBADIAN
Authors: Pramudita Antonia Yosephine Restu , Yudha Trigasi Ayu Carina , Romadhana Winggo
Published: April 2024

This research aims to determine the relationship between personality based on the Big Five Personalities and the psychological well-being among the nurses. Personality according to the Big Five Personality can be seen through five factors: extraversion, neuroticism, openness, agreeableness, and conscientiousness. Psychological well-being has six dimensions: self-acceptance, positive relationships with others, autonomy, purpose in life, environmental mastery, and personal growth. The research was conducted with 65 nurses who worked in a private hospital in Surabaya as respondents. The measuring instruments used are the Big Five Inventory and Ryff's Psychological Well-Being Scale. The analysis technique used is Spearman's Rho. Correlation tests were carried out between five personality factors and six dimensions of psychological well-being. From the results of the correlation analysis carried out, it was found that the extraversion factor was positively correlated with all dimensions of psychological well-being. The openness, agreeableness, and conscientiousness factors are negatively correlated with the self-acceptance dimension, and positively correlated with the other five dimensions of psychological well-being. Meanwhile, the neuroticism factor in personality is negatively correlated with all dimensions of psychological well-being
PENGELOLAAN KARIER SUMBER DAYA MANUSIA
Authors: Faqih Abdul , Haqq Mu’tashim Abdil , Alghifari M. Sulton , Wahjono Sentot Imam
Published: April 2024

This research discusses the importance of managing human resource careers in an organizational environment.  Career is a key factor in improving employee performance, achieving organizational goals, and maintaining employee satisfaction. This study used various references related to human resource management, including several related studies conducted by Wahjono, Sentot Imam, and colleagues. Research methodology involves literature analysis and case studies with the aim of gaining a deeper understanding of effective career management practices
The Relationship of Perceived Social Support with Level of Insight and Treatment Adherence in Individuals Diagnosed with Schizophrenia and Bipolar Disorder
Authors: Kocakaya Hanife , Arslan Kübra , Buturak Şadiye , Turgal Ebru
Published: April 2024

Purpose: This study aims to examine the relationship between perceived social support, insight, and treatment adherence in patients with schizophrenia and bipolar disorder.

Materials and Methods:This study was conducted with 110 individuals, 55 of whom were bipolar and 55 patients with schizophrenia, who received inpatient treatment in the last 1 year, were in remission. Sociodemographic and clinical data form, Young Mania Rating Scale (YMDS), Clinical Global Impressions Scale (CGI), Schedule for Assessment of Insight (SAI), Morisky Medication Adherence Scale (MMAS), and Multidimensional Scale of Perceived Social Support (MSPSS) were administered to the participants.

Results: The mean age was 40.47±12.96 for bipolar patients and 40.45±11.71 for schizophrenics. Perceived family, friend, significant others support, and total support was found to be higher (p=0.000, p=0.000, p=0.004, p=0.000, respectively) in bipolar patients, and the highest support was perceived from family, followed by friends and significant people. Although the groups did not differ in terms of treatment adherence (p=0.083), the insight score was significantly higher in bipolar patients (p=0.001). Groups were evaluated with hierarchical regression analysis in terms of factors affecting perceived social support. Gender, years of education, insight, and treatment adherence were found to be predictive of social support (p=0.04, p=0.01, p
Telepharmacy intervention: Can it impact medication adherence among patients with chronic disease?
Authors: Kambira Pretty  Falena Atmanda , Noviani Lusy , Hendrawan Angelina M. E. L.
Published: April 2024

Background: Medication adherence among patients with chronic diseases remains challenging for healthcare professionals. The large number and types of drugs that must be taken in the long term and the lack of knowledge related to drugs and diseases are factors that affect patient compliance. Telepharmacy is expected to improve patient medication adherence by providing easy access to consult with pharmacists.
Objective: To assess the effect of telepharmacy on chronic patient medication adherence.
Methods: This study had a cross-sectional study design, and the study population was Lifepack application users. The data was collected through an online questionnaire distributed through the Lifepack platform. The adherence was evaluated using the Morisky Medication Adherence Scale, and the association of telepharmacy and patient medication adherence was examined using the chi-square independence test with significance at p < 0.05.
Results: In a study comprising of 94 respondents, a proportional ratio of respondents who used and did not use telepharmacy services was observed (45.75% and  54.25%, respectively). Analysis using the chi-square statistic (χ²) demonstrated a significant association between telepharmacy and patient adherence (χ² = 64.745, df = 1, p < 0.001). Furthermore, the odds ratio (OR) revealed a substantial difference in adherence, with an OR of 122.67 (95% CI [27.58, 545.66]).
Conclusion: Telepharmacy has a significant impact on medication adherence in chronic patients.
Exploration of probiotics on antioxidant activity of serum NLC coenzyme Q10 using the DPPH (2,2-diphenyl-1-picrylhidrazyl) method
Authors: Pratiwi Elasari Dwi , Mayangsari Fransisca Dita , Susanti Irma
Published: April 2024

Background: The skin ageing process can be slowed by routinely caring for the skin using serum cosmetics containing antioxidants such as Co-enzyme Q10 (CoQ10). However, CoQ10 has a drawback, which is low penetration into the skin. In this study, an antiaging serum preparation with the active ingredient NLC-CoQ10 was prepared. Probiotics were added to this preparation as a second active ingredient to enhance antioxidant activity.
Objective: This study aimed to analyse the effect of probiotic concentration on the physical characteristics and antioxidant activity of NLC-CoQ10 serum.
Method: NLC-CoQ10 was mixed with serum base and 0% probiotic (Formula One), 2% probiotic (Formula Two), and 4% probiotic (Formula Three). After that, physical characteristics and antioxidant activity were observed.
Results: The results show that the physical characteristics of all formulas fulfil the specifications. All formulas had pH values between 4 and 7 and a viscosity value between 230 and 1150 cPs. The formula with the highest viscosity value is F1, 352.00 ± 2.00. All formulas have statistically different IC50 values. IC50 values for F1, F2 and F3 respectively, are 317.809 ± 2.117; 307.985 ± 2.089; 257.549 ± 1.573.
Conclusion: The antioxidant activity increases with increasing concentrations of probiotics in NLC-CoQ10 serum. Meanwhile, the viscosity value decreases with a decreasing concentration of probiotics.
Anti-inflammatory effects of eggshell membrane hydrolysates on carrageenan-induced rat
Authors: Vikasari Suci Nar , Sukandar Elin Yulinah , Suciati Tri , Adnyana I Ketut
Published: April 2024

Background: Eggshells are one of the most common culinary wastes, yet using eggshell membrane detritus in medical treatments remains largely unexplored.
Objective: This study aims to assess the anti-inflammatory potential of eggshell membrane hydrolysate.
Method: Eggshell membrane hydrolysate was prepared using acid-base hydrolysis. The intraplantar carrageenan-induced inﬂammation model was used to test the anti-inflammatory effect. The experimental group consisted of a control, comparison (4.5 mg/kg BW diclofenac-Na, 4.5 mg/kg BW hyaluronic acid, and 45 mg/kg BW collagen), and eggshell membrane hydrolysates (9, 22.5, 45 and 90 mg/kg BW). Observations of inflammation, percentage of inflammation, and percentage of inhibition of inflammation were measured every 30 minutes for 180 minutes. Statistical analysis was performed using the t-test and also trendline analysis.
Result: The findings revealed that collagen and hyaluronic acid demonstrated the ability to suppress inflammation compared to controls (p < 0.05). Compared to the control group, the group that received eggshell membrane hydrolysate at doses of 9, 22.5, 45, and 90 mg/kg BW also exhibited inhibition of inflammation (p < 0.05). Furthermore, increasing the dosage of eggshell membrane hydrolysate correlated with an increase in the percentage of inflammation inhibition in carrageenan-induced rats.
Conclusion: Eggshell membrane hydrolysate has the potential to act as an anti-inflammatory agent.
The effect of cognitive decline on the medication adherence in patients with type II diabetes mellitus
Authors: Soraya Indana Ayu , Sauriasari Rani , Prawirohardjo Pukovisa , Risni Hindun Wilda
Published: April 2024

Background: Type II Diabetes Mellitus (T2DM) is a risk factor for decreased cognitive function that is rarely recognised by patients, apart from age and other factors.
Objective: This study aims to assess the effect of decreased cognitive function on medication adherence in T2DM patients.
Method: This study used a cross-sectional design conducted at the Pasar Minggu Community Health Center, Jakarta, Indonesia. Cognitive function was assessed using the validated Indonesian version of the Montreal Cognitive Assessment (MoCA-Ina) questionnaire.
Results: One hundred twenty-seven T2DM patients (75.6% female) with a mean age of 58.69 years were recruited. The proportion of T2DM patients with decreased cognitive function was quite high, namely 61%. The proportion of non-adherent patients in the group with decreased cognitive function (70.6%) was greater than in the normal group (29.4%). Decreased cognitive function significantly affected non-adherence in taking medication with aOR 3.744 (95% CI 1.485–9.442), p = 0.005, after controlling for age, education level, HbA1c value, and comorbid dyslipidemia.
Conclusion: Patients with decreased cognitive function are 3.7 times more likely to be non-compliant with medication, regardless of age, education level, HbA1c value, and dyslipidemia. Special management is needed for T2DM patients with decreased cognitive function, such as caregiver assistance, education by pharmacists, and simpler drug regimes.
Quantitative analysis of flavonoids and phenolics extracted from Diplazium esculentum (Retz.) Sw. for their anti-hyperglycemic potential
Authors: Devi Silvera , Rambah Tiara Mulyani , Syaifullah Mhd. Muslim , Mukhlis  , Itnawita  , Hendra Rudi
Published: April 2024

Background: Hyperglycemia arises from excessive blood glucose due to starch hydrolysis by α-amylase and α-glucosidase. Drugs like acarbose inhibit these enzymes to manage hyperglycemia, but long-term use poses risks. Fern species Diplazium esculentum metabolites show promise as acarbose alternatives.
Methods: Sequential extraction of secondary metabolites from D. esculentum involved solvents in successive stages: hexane, ethyl acetate, and water. Subsequently, an assessment of phenolic and flavonoid concentrations within the ethyl acetate and aqueous extracts was conducted. Furthermore, the investigation encompassed the evaluation of % inhibition and IC50 values pertaining to the activities of α-amylase and α-glucosidase.
Results: The findings indicated that the flavonoid concentrations in the ethyl acetate and aqueous extracts were 146.90 ± 27.20 µg quercetin equivalent per gram of fresh weight (eq./g FW) and 101.95 ± 40.62 µg quercetin eq./g FW, respectively. In terms of total phenolic content, the ethyl acetate extract contained 121.25 ± 8.29 µg of gallic acid eq./g FW, whereas the aqueous extract had 109.90 ± 7.22 µg gallic acid eq./g FW. The IC50 values demonstrated that the aqueous extract had moderate inhibitory effects on α-amylase with a value of 108.05 µg/mL, while acarbose exhibited very strong inhibition with a value of 3.12.
Conclusion: Ferns are relatively ineffective in treating hyperglycemia.
Antinociceptive and anti-inflammatory effect of Passiflora edulis leaves extract in acetic acid-induced pain and carrageenan-induced paw oedema in vivo
Authors: Sandhiutami Ni Made Dwi , Desmiaty Yesi , Fahleni  , Fakhran Mohammad Haidi
Published: April 2024

Background: In Indonesia, people commonly treat pain and inflammation with herbs. Passiflora edulis leaves extract (PLE) is known to contain many chemical compounds that are useful as analgesic and anti-inflammatory treatments. However, there is very limited scientific literature that reports the results of P. edulis in reducing pain and inflammation.
Objective: This research aims to evaluate the antinociceptive and anti-inflammatory effects of PLE.
Method: PLE was extracted by Ultrasonic-Assisted Extraction (UAE). The PLE at doses of 20, 40 and 80 mg/200g BW (PLE-20, PLE-40, and PLE-80) and diclofenac sodium (Dic. sod. at a dose of 2.7 mg/200g BW as a positive control group was tested for antinociceptive and anti-inflammatory effects in experimental animal models (n=5). The effect of antinociceptive was evaluated by the wriggling in mice by acetic acid-induced, and the effect of acute anti-inflammatory was evaluated by carrageenan-induced in rats.
Result: PLE at doses of 20, 40, and 80 mg/200g BW showed a significant antinociceptive effect at acetic acid-induced wriggling and inhibition of the oedema. Higher doses lead to more pronounced effects. The greater effect of antinociceptive was observed at PLE-80 (64.55%), and inhibition of the oedema was observed at PLE-80 (34.33%).
Conclusion: PLE significantly reduced pain and acute inflammation in the animal-tested models.
The mechanism of action underlying antibacterial activity of a diterpene quinone derivative against Staphylococcus aureus through the in vitro and in silico assays
Authors: Ulfah Aida Julia , Hamidy Muhammad Yulis , Teruna Hilwan Yuda
Published: April 2024

Background: The need for new antibacterials to combat resistance is still constrained by the availability of antibacterials that are safe to use. Diterpene quinone-derived compounds are proven to have antibacterial activity. However,  their mechanism of action is unknown.
Objective: This study aims to determine the mechanism of antibacterial action of a diterpene quinone (6O7AR) on Staphylococcus aureus through in vitro and in silico assays.
Method: MIC tests were performed using microdilution, and MBC determinations were carried out on MHA media. In vitro assays were conducted using membrane permeabilizing with Tris, Triton X-100, and ATPase-inhibiting agents with NaN3. Docking was performed on 2XCT proteins in S. aureus bacteria using AutoDock Vina.
Result: The MIC and MBC results of 6O7AR were 300 μM and 2400 μM, respectively. The in vitro assay result suggested that the antimicrobial activities of 6O7AR were associated with the inhibition of ATPase function and disrupting membrane function. The docking results showed that the compound possessed good interactions with the 2XCT proteins of S. aureus.
Conclusion: 6O7AR exhibited good antibacterial activity. Based on in vitro and in silico assays, the mechanism of action of this compound is related to the disruption of bacterial membrane function, and it has the potential to inhibit the ATPase enzyme and the S. aureus gyrase.
The effects of DAGUSIBU education on the level of community knowledge in obtaining, using, storing, and disposing of drugs in West Java, Indonesia
Authors: Noviani Lusy , Rachmawati Putriana , Febrinella Catleya
Published: April 2024

Background: In 2022, health products were the best-selling category in the marketplace. Over-the-counter medicines are the only types of drugs that can be sold online. However, in reality, many prescription drugs are being traded online. A lack of public awareness about purchasing drugs online can have negative consequences, such as buying counterfeit and hazardous medicines and drugs without distribution permits. A community health initiative for public education, DAGUSIBU, is being powered by pharmacists and must be encouraged.    
Objective: To educate the public about the DAGUSIBU and measure the changes in public knowledge after the education process.    
Methods: A quasi-experimental one-group pre-test and post-test method was used to design the study. Univariate and bivariate Wilcoxon tests were used to analyse the data.    
Results: The level of public knowledge before education was 49.41% in the poor category, 36.72% in the good category, and 13.87% in the adequate category. Following education, the respondents’ level of knowledge was classified as good (48.46%), adequate (41.12%) and poor (10.42%). The p-value of the level of knowledge before and after education was < 0.05, according to the Wilcoxon test.    
Conclusion: DAGUSIBU education in digital platforms to obtain drugs had a significant impact on public knowledge
Capacity & Level of Service Assessment of Gwarko Intersection
Authors: Shestha Sudip , C. Suman G. , Dangi Kamal , Mehta Santosh , Yadav Pappu Kumar , Das Rshan
Published: April 2024

This report gives an overall view of the existing condition of the Gwarko intersection & various routes for accessing the location. This intersection is one of the busiest and major intersections of the valley that connects various major places that are Satdobato, Imadol, Mangalbazar, and Balkumari. The performance of the intersection is determined in terms of the control delay and by following methodologies of the Indo Highway Capacity Manual (Indo HCM) 2017. The traffic volume was estimated through CCTV film from the Metropolitan Police Office, Ranipokhari, Kathmandu. The classified vehicle count is done to determine the traffic flow at peak traffic conditions. The data collected refers to the weekday flows for the office hours between 8:00 am to 11:00 am and 4:00 pm to 7:00 pm (2020/08/05-2020/08/08). From the result, we got to know that the motorcycles/cycle volume is comparatively more than the volume of any other vehicle while the 3- wheeler & HGV volume was least among all. Then the pinnacle 15-minute progression of the pinnacle hour was taken to decide the least Pinnacle Hour Variable and the least PHF were utilized to decide the pinnacle hour stream for additional estimations. Saturation flow for each of the approaches of base intersection from the equation of unit base saturation flow, Base saturation flow is calculated (USF0) by different adjustment factors were calculated by multiplying to the Unit base saturation flow to obtain saturation flow rate of each bound. The vehicle development was isolated into various stages. Immersion stream rate, successful green time and general cycle length of every heading are taken as the contribution for limit computation. The absolute control postponement of every leg and the course of the stream were taken as the contribution to the investigation of the degree of administration assurance. At last, the LOS of every heading of the stream was acquired, which showed the LOS is preferable toward the beginning of the day over at night.
Los indicadores financieros y no financieros como herramientas de gestión en el sector ferretero
Authors: Villa Cueva Johanna Alexandra , Crespo Córdova Abraham Boanerges
Published: April 2024

El estudio desarrollado tuvo como propósito identificar los indicadores de desempeño financieros y no financieros y su importancia en la evaluación de la gestión de las empresas que integran el sector ferretero. Para cumplir con dicho objetivo se utilizó como metodología un enfoque cualitativo, de tipo descriptivo. En primera instancia, en un contexto general, de nivel macro se efectúo una revisión de la literatura, para luego, realizar entrevistas cualitativas a 20 gerentes o dueños de las empresas bajo la actividad correspondiente a la venta al por mayor de artículos de ferreterías y, de esta manera emparejar la información recolectada por ambos medios. En la literatura, se halló que es recomendable definir los indicadores de gestión en función de los factores claves de éxito, y, por otro lado, en relación con la práctica se encontró que, las empresas del sector de estudio son evaluadas por indicadores financieros (liquidez, rentabilidad, endeudamiento, etc.) y no financieros (productividad laboral, índice de devoluciones, etc.). Finalmente, los resultados permitieron concluir que el uso de este tipo de indicadores claves de gestión son importantes, ya que, permiten evaluar a las empresas, para a partir de ello potenciar su éxito empresarial y promover la toma de decisiones acertadas.
Seguridad alimentaria, jefatura de hogar, género y posesión de cultivos y hortalizas en hogares rurales
Authors: Carmona Silva José Luis , Cantellano Rodríguez Humberto , Velazco Torres Mariano , López Cadena Zoila
Published: April 2024

El objetivo del trabajo fue analizar la relación que guarda la seguridad alimentaria en hogares rurales con variables como jefatura del hogar, posesión de cultivos, hortalizas y árboles frutales; así como la presencia de menores de edad en la localidad de San Felipe Cuapexco, Puebla, México. La metodología empleada fue de tipo mixto, se realizaron entrevistas a profundidad con autoridades y personajes clave y se aplicaron 105 cuestionarios a los jefes de familia. Los resultados obtenidos muestran que en San Felipe Cuapexco predominan los niveles de inseguridad alimentaria leve y moderado, no existe una asociación significativa entre la presencia de menores de edad, número de especies cultivadas, árboles frutales y los grados de inseguridad alimentaria. Existe una relación positiva entre el número de cultivos y los niveles de seguridad alimentaria. Por otro lado, los hogares con mujeres como jefes de familia son más propensos a padecer inseguridad alimentaria.
Clinical Practice Guidelines for Rheumatoid Arthritis PANLAR: A Comprehensive Approach for All
Authors: Fajardo Estefanía
Published: April 2024

After 15 years, PANLAR will update the Rheumatoid Arthritis (RA) guidelines, aiming to address the specificities of healthcare systems and disease management in its member countries. Additionally, it hopes to make them user-friendly for diverse strategic audiences.
Attachment of Salmonella Typhimurium to Fish Surfaces from a Suspension in Seawater and the Effect of Subsequent Washing
Authors: Kumar Sanath H
Published: April 2024

ackground: Salmonella contamination of seafood is an important consumer health concern. Anthropogenic contamination of coastal-marine water is an important source of seafood contamination with Salmonella. In this study, we aimed to investigate the extent of Salmonella attachment when fish is exposed to contaminated seawater and also, the effect of washing on the removal of Salmonella attached to fish surface.

Methods and Findings: Bombay duck (Harpadon nehereus) fish was dipped in seawater artificially contaminated with 5 log CFU/ ml Salmonella Typhimurium for 30, 45 and 60 seconds and the number of bacteria present on the fish surface was quantified by surface plating. Separately, the effect of rinsing Salmonella-contaminated fish for 30, 45 and 60 seconds on the removal of Salmonella from the fish surface was investigated. The results showed attachment of bacteria in significant numbers, in the range of 3.6 – 4.16 log CFU/g, within 60 seconds of exposure to Salmonella-contaminated seawater. However, no significant reduction in the Salmonella counts was observed after 30 to 60 seconds of rinsing of fish in freshwater.

Conclusion: The results suggest that Salmonella Typhimurium can readily attach to the fish surface from a seawater medium and resist detachment by routine washing procedures.
Pengaruh Penambahan Glukosa pada Pengencer Masa Kriopreservasi
Authors: Nuralamsyah M. , Mansur Musdalifa , M. Armayani
Published: April 2024

Penelitian ini bertujuan untuk mengetahui pengaruh suplementasi glukosa dalam pengencer andromed terhadap kualitas spermatozoa sapi limosin selama masa kriopreservasi dan untuk mengetahui konsentrasi glukosa yang terbaik dalam mempertahankan kualitas spermatozoa sapi limousine selama masa kriopreservasi. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) dengan 5 taraf perlakuan dan 4 kali ulangan yaitu, 0%, 0,125%, 0,25%, 0,5%, dan 1%. Parameter yang diamati yaitu Motilitas Spermatozoa, Viabilitas Spermatozoa, Abnormalitas Spermatozoa. Hasil penelitian ini menunjukkan bahwa perlakuan penambahan glukosa berpengaruh sangat nyata terhadap Motilitas Spermatozoa, Perlakuan dengan penambahan glukosa 1% menghasilkan Motilitas yang lebih tinggi, Hasil penelitian ini menun jukkan bahwa perlakuan penanbahan glukosa berpengaruh sangat nyata terhadap Viabilitas Spermatozoa. Perlakuan dengan penambahan glukosa 1% menghasilkan Viabilitas yang lebih tinggi, Penambahan glukosa tidak berpengaruh nyata terhadap Abnormalitas Spermatozoa setelah masa kriopreservasi, Disimpulkan bahwa: Suplementasi glukosa dalam pengencer andromed berpengaruh terhadap viabilitas dan motilitas setelah masa kriopreservasi namun tidak berpengaruh terhadap abnormalitas setelah masa kriopreservasi, Dan Presentase glukosa yang terbaik dalam mempertahankan kualitas spermatozoa sapi limousine selama kriopreservasi adalah penambahan glukosa 1%.
Pengaruh Lama Simpan Yoghurt Dengan Penambahan Sari Kurma (Phoniex dactylifera) Ajwa Dalam Suhu Refrigerator Terhadap Kualitas Organoleptik, pH Dan Viskositas
Authors: Salsabila Maulida , Puspitarini Oktavia Rahayu , Retnaningtyas Irawati Dinasari , Susilowati Sri
Published: April 2024

Penelitian ini bertujuan untuk menganalisis pengaruh lama simpan yoghurt dengan penambahan sari kurma (Phoniex dactylifera) ajwa dalam suhu refrigerator terhadap kualitas organoleptik, pH dan viskositas. Metode penelitian adalah eksperimen dengan menggunakan Rancangan Acak Lengkap (RAL), dengan 4 perlakuan dan 5 ulangan. Perlakuannya adalah lama simpan yang terdiri dari P0 (Kontrol), P1(5 hari), P2 (10 hari) dan P3 (15 hari). Variabel yang diamati pada penelitian ini yaitu kualitas organoleptik, pH dan viskositas. Data penelitian dianalisis ANOVA (Analysis of Variance) dan dilanjutkan dengan uji BNT (Beda Nyata Terkecil). Hasil penelitian menunjukkan bahwa lama simpan yoghurt dengan penambahan sari kurma ajwa berpengaruh nyata (P<0,05) terhadap kualitas organoleptik (aroma dan rasa), nilai pH dan viskositas. Lama simpan yoghurt dengan penambahan sari kurma ajwa berpengaruh sangat nyata (P<0,01) terhadap kualitas organoleptik (tekstur dan kesukaan). Lama simpan yoghurt dengan penambahan sari kurma ajwa tidak berpengaruh nyata (P>0,05) terhadap kualitas organoleptik (warna). Rerata nilai organoleptik terhadap aroma pada (L0) 2,50a, (L1) 2,58ab, (L2) 2,60ab, (L3) 2,68b. Rerata nilai organoleptik terhadap rasa pada (L0) 2,56a, (L1) 2,56a, (L2) 3,00b, (L3) 3,06b. Rerata nilai organoleptik terhadap tekstur pada (L0) 2,00a, (L1) 2,46b, (L2) 2,42b, (L3) 2,58b. Rerata nilai organoleptik terhadap warna pada (L0) 2,00, (L1) 2,12, (L2) 2,14, (L3) 2,16. Rerata nilai organoleptik terhadap tingkat kesukaan pada (L0) 2,80b, (L1) 2,70b, (L2) 2,48b, (L3) 2,02a. Rerata nilai pH yoghurt (L0) 4,15a, (L1) 4,17ab, (L2) 4,21ab, (L3) 4,24b. Rerata nilai viskositas (mpa.s) yoghurt (L0) 1191,2a, (L1) 1225,4ab, (L2) 1273,4b, (L3) 1301,6b. Kesimpulannya adalah lama simpan optimal yoghurt dengan penambahan sari kurma ajwa 20% dapat disimpan selama 10 hari dalam refrigerator bersuhu 9°C memiliki kualitas organoleptik, pH dan viskositas terbaik.
ON THE QUADRA MERSENNE-JACOBSTHAL, QUADRA MERSENNE-PELL AND RELATED QUATERNION SEQUENCES
Authors: KIZILIRMAK GUL OZKAN , CAKACI SENANUR
Published: April 2024

The aim of this paper is primarily to introduce the quadra Mersenne-Jacobsthal and quadra Mersenne-Pell sequences. Then, the Binet formulas and generating functions for these sequences are obtained. Moreover, quadra Mersenne-Jacobsthal and quadra Mersenne-Pell quaternions were defined and Binet formulas, generating functions, some quaternion sums and relations were obtained for these quaternions.
ON t^*-SET AND B^*-SET IN NANO TOPOLOGICAL SPACES
Authors: NARASIMMAN SEKAR , RAGHAVAN ASOKAN , ILANGOVAN RAJASEKARAN , GANDHI SELVI
Published: April 2024

We investigate the class of nano locally **b-closed sets in this paper. The purpose of this work is to introduce several novel sets, such as nano closed sets,nano t*-sets, nano *b-closed sets, nano B*-set and nano **b-closed sets, and to investigate the properties of these sets. We also introduced the concept of nano **b-open sets and nano locally **b-open sets, as well as examined some of their features.