bluuebunny/crossref_metadata_2025 huggingface dataset:
The improvement and mechanism of Scutellaria baicalensis Georgi stems and leaves flavonoids on okadaic acid-induced learning and memory impairment in rats
Authors: Shuai Ma , Congcong Xu , Yongcai Dong , Caixia Li , Shang Yazhen
Published: December 2022

Background
AD is a progressive neurodegenerative disease that seriously threatens the physical and mental health for the elderly. The disease is pathologically associated with Aβ plaque deposition, tau hyperphosphorylation, cholinergic damage, oxidative stress and neuroinflammation. okadaic acid (OA), an inhibitor of protein phosphatases PP1 and PP2A, can reduce the dephosphorylation of phosphorylated tau protein and result in the hyperphosphorylation of tau protein, which in turn leads to NFT deposition and indirectly induces AD. Therefore, the brain injury in mimic AD model established by intracerebroventricular injection of OA conforms to the pathogenesis of AD in rats.
Objective
To investigate the effect and mechanism of Scutellaria baicalensis Georgi stems and leaves flavonoids (SSFs) on learning and memory impairment induced by intracerebroventricular injection of OA in rats.
Methods
The mimic AD model of memory impairment of rats was established by intracerebroventricular injection of OA. Morris water maze was to screen the successful model of memory impairment. The successful model rats were randomly divided into model group, three doses of groups for SSFs 25, 50, and 100 mg/kg, and positive drug Ginkgo biloba tablet (GLT) 200 mg/kg group. The rats’ learning and memory abilities were detected with the Morris water maze. The morphological changes of nerve cells were observed by hematoxylin-eosin (HE) staining. The Choline acetyltransferase (ChAT) protein expressions were detected with immunohistochemistry (IHC). The phosphorylation level of tau protein at Ser262 and Ser396 sites was assayed with Western blotting (WB). The activities of inducible nitric oxide synthase (iNOS) and constitutive nitric oxide synthase (cNOS) were measured with ultraviolet spectrophotometry. Enzyme-linked immunosorbent assay (ELISA) was used to detect the level of inflammatory factors interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6).
Results
The intracerebroventricular injection of OA caused the rats’ learning and memory impairment and neuropathological changes. The protein expression of ChAT was reduced (P < 0.01) and the phosphorylation levels of tau protein at Ser262 and Ser396 were significantly increased (P < 0.01), the activity of iNOS increased (P < 0.01) and cNOS decreased (P < 0.05) in the hippocampus and cerebral cortex. The levels of IL-1β and TNF-α in the cerebral cortex were increased (P < 0.01), and the level of IL-6 was decreased (P < 0.05). The three doses of SSFs and GLT treatment to rats can differently ameliorate the above abnormal changes caused by OA.
Conclusion
SSFs can improve the rats’ learning and memory impairment caused by intracerebroventricular injection of OA and the effective mechanism may be related to the positive regulation in ChAT protein expression, tau hyperphosphorylation, NOS activity, and inflammatory cytokine levels.
Assessing the effect of sample storage time on viral detection using a rapid and cost-effective CTAB-based extraction method
Authors: Mark Deogratius , Sikazwe Geofrey , Saggaf Maliha , Tairo Fred , Ndunguru Joseph , Chiunga Evangelista , Lusana James , Kweka Elisiana , Maghembe Reuben , Bachwenkizi Hilda
Published: December 2022

Background: Cassava leaf samples can degrade quickly during storage and transportation from distant areas. Proper sampling and the use of efficient cheap storage methods are critical to obtain sufficient quality of DNA and RNA for plant virus epidemiology and to improve understanding on disease control. This is practical when samples are collected from isolated zones distant from a laboratory, or in developing countries that lack a supply of money and materials for virus diagnostics.
Results: The effect of sample storage duration on nucleic acid (NA) quality on virus detection was investigated in this study. A simple, rapid, and cost-effective CTAB-based approach (M3) for single NA extraction was optimized and evaluated together with two existing CTAB-based methods (M1 and M2) for extraction of NA from fresh and herbarium cassava leaves stored at; 1, 8, 26, and 56 months. The quantity of DNA and quality of both DNA and RNA were evaluated using Nanodrop 2000c UV–vis Spectrophotometer and agarose gel electrophoreses, and the rate of sample degradation was estimated using a simple mathematical model in Matlab computational software.
The results show that there is no significant difference between M1 and M2 in the mean concentration of DNA but there was a significant difference between M3 and the other two methods at p < 0.005. The mean concentration of DNA extracted using M3 was higher at 1 and 8 months of age. M3 and M2 produced high concentrations at the age of 26 and 56 months. Using a developed scale for quality score, M3 and M2 produced high-quality DNA from fresh samples. All methods produced poor-quality DNA and RNA at the age of 8 and 26 months and no visual bands at the age of 56 months. Statistically, there was a significant difference in the mean quality of DNA between M1 and M2 but there was no significant difference between M3 and the other two methods at p < 0.005. However, Cassava brown streak virus (CBSV) and Ugandan cassava brown streak virus (UCBSV) were readily detected by RT-PCR from RNA isolated using M3. The quality of DNA declined per storage time at the rate of 0.0493 and 0.0521/month while RNA was 0.0678 and 0.0744/month. Modified CTAB extracted a sufficient amount of NA of high quality for a third of the time (28/95min) compared to the existing two methods.
Conclusion: Our method will provide the cost-effective, quick, and simple processing of fresh and dry samples which will quicken and guide the decision process on when and what type of sample to process for plant disease management and surveillance actions.
Refined Instantaneous Frequency Estimation with Application to Sparse Signal Reconstruction
Authors: Ali Sadiq , Khan Nabeel Ali , Shah Feroz
Published: December 2022

In this study, we propose an instantaneous frequency (IF) estimation and then apply this algorithm for the reconstruction of missing samples. The proposed IF estimation and sparse reconstruction algorithm is developed by adding a refinement step where the crude estimates of IFs and signal components are further improved through the re-estimation stage. During the re-estimation stage, both IFs, as well as the signal components, are re-estimated by removing all the remaining components. Experimental results indicate that the proposed strategy improves both the accuracy of IF estimates as well as missing samples.
Implementation strategies, facilitators, and barriers to scaling up and sustaining post pregnancy family planning, a mixed-methods systematic review
Authors: Nabhan Ashraf , kabra Rita , Kiarie James
Published: December 2022

Objectives

This review aims to describe and assess the quality of the evidence on implementation strategies, facilitators, and barriers to scaling up and sustaining post pregnancy family planning.

Search methods

We will search the following electronic bibliographic databases (from inception to 15th October 2022): MEDLINE, PubMed, Scopus, the Cochrane Library, and Global Index Medicus, World Health Organization. We will also search gray literature using the search engines and websites of relevant organizations. We will hand search citations in included articles. We will contact experts and groups of scientists in the field for relevant reports.

Selection criteria

We will include reports of primary studies on scaling up post pregnancy family planning. We will include studies conducted in any country, language, and publication date. We will not exclude studies based on methodological limitations.

Data collection and analysis

We will assess titles and abstracts then potential full-text papers according to the inclusion criteria. We will include reports that met the inclusion criteria. We will extract information including country, country's economic category, study type and design, strategies of scaling up post pregnancy family planning, implementation outcome evaluated in each study, and barriers and facilitators. We will use a deductive thematic synthesis process. We will use GRADE-CERQual to assess our confidence in the findings

Results

This is a protocol for a mixed methods systematic review. The review will summarize reports used either separate or bundled strategies for scaling-up post pregnancy family planning. These include strategies for healthcare infrastructure, policy and regulation, financing, human resource, and people at the point of care. We will summarize the factors that influence scaling up post pregnancy family planning.
Impact of digital stress on negative emotions and physical complaints in the home office
Authors: Wrede Sammy J.S. , Claassen Kevin , Anjos Dominique Rodil dos , Kettschau Jan P. , Broding Horst C.
Published: December 2022

Background
Due to the COVID-19 pandemic many employees perform under increasingly digital conditions. Enabling home office became mandatory for companies wherever possible in consideration of the ongoing pandemic. Simultaneously, studies report on digital stress. The current literature lacks investigations of digital stress on psychosomatic outcomes, emotions and disease.
Objectives
This study aims to answer the research question 'How has digital stress developed over the course of the pandemic? Does digital stress predict longitudinal differences in negative emotions and physical complaints in the home office setting?'
Methods
An online survey was conducted among 441 employees in 2020 and 398 employees in 2022 from three municipal administrations in Germany, who were working from home at least occasionally. In a first step, a hierarchical agglomerative cluster analysis is used to detect the cluster of digitally stressed employees. In addition, multivariate first-difference OLS regressions were performed on digital stress, negative emotions, and physical complaints.
Results
The analysis revealed an increase from 8.5 to 20.2 percent in digital stress, while negative emotions and physical complaints did not show significant differences. In the multivariate model the change in the proportion of digitally stressed is between 3.8 and 16.8 percent, while the control variables explain around 9 percent. Digital stress might be slightly predictive for negative emotions, but not for physical complaints.
Conclusions
The study emphasizes rising digital stress, which contradicts an adaption to the digital working conditions within the observed period. Nevertheless, the psychosomatic relations are low or lagged. Further research investigating on digital stress and countermeasures especially for working from home to prevent harmful long-term effects resulting from distress is needed.
Medien als Vermittlungsinstanz transnationaler Identitäten
Authors: Teichert Jeannine , Meister Dorothee M.
Published: December 2022

In diesem Beitrag werden Identitätsaushandlungen deutscher Migrant:innen über Medien in Grossbritannien im Kontext des Brexit diskutiert. Basierend auf der theoretischen Verortung nach Elias und Scotson (1990) von Etablierten und Aussenseitern zeigen sich nach dem EU-Referendum bei den deutschen Ausgewanderten Unsicherheiten bezüglich ihrer transnationalen europäischen Identität. Nach intensiven Anstrengungen über Jahre und teils Jahrzehnte, eine neue private und berufliche Heimat in Grossbritannien aufzubauen, scheint sich vor dem Hintergrund von Grossbritanniens EU-Austritt und des damit verbundenen gesellschaftlichen Wandels alles zu ändern. Soziale Ausgrenzung, Trennung von früheren Freund:innen sowie die Angst vor einem möglichen Ausschluss vom Arbeitsmarkt aufgrund politischer Unstimmigkeiten führen bei den Migrierten schliesslich zu Überlegungen, wieder nach Deutschland zurückzukehren. Auf der anderen Seite fühlen sie sich ihrer ursprünglichen Heimat immer mehr entfremdet, obwohl alle Teilnehmenden noch ein bestehendes soziales Netzwerk in Deutschland pflegen und die deutsche Sprache, Kultur und soziale Einstellung vermissen. Als Outsider in beiden Ländern hilft ihnen wiederum der mediale Austausch mit Freund:innen und Familie in Deutschland, um Entfremdungsängste abzubauen und ihre hybride transnationale europäische Identität zu stärken.c
Von Glaskonstruktionen und Kinosälen
Authors: Roselli Antonio
Published: December 2022

In Walter Benjamins Kunstwerkaufsatz-Komplex, im Passagen-Werk sowie in einzelnen Aufsätzen findet sich in Ansätzen eine Theorie politischer Kollektive, die wiederum eng an Fragen der Struktur von öffentlichen und privaten Räumen gebunden ist. Indem die Glaskonstruktion die «gute Stube» ablöst, wird mit der Abkehr vom bürgerlichen Subjekt zugleich die Voraussetzung für eine neue Form des Kollektivs geschaffen: Die Kollektivwahrnehmung in ihrer doppelten Bedeutung einer kollektiven Wahrnehmung und einer Wahrnehmung des Kollektivs, wie sie im Kinosaal und durch die Glasbauten stattfindet, lässt ein dialektisches Verhältnis zwischen Individuum und Masse entstehen, wodurch sich die Masse auch qualitativ verändert und zum Kollektiv wird.
Corona, Distanzierung, Isolation und das Medium unserer Sinnlichkeit
Authors: Meder Norbert
Published: December 2022

Der Beitrag will zeigen, was Corona, Distanzierung und Isolation mit unserem sinnlichen Erleben macht. Dabei wird von einem extremen Fall ausgegangen, dass man als Single lebt, also keine familiäre Umgebung hat, in der trotz Corona Intimität möglich oder sogar unausweichlich ist. Dafür wird zuerst unsere Leiblichkeit als Medium charakterisiert und sodann auf die mediale Spezifizierung unserer Leiblichkeit in unseren fünf Sinnen eingegangen. Anschliessend beschreibt der Artikel die Einschränkung und die Transformation des sinnlichen Erlebens in den einzelnen Sinnen unter der Bedingung von Isolation.
Die Zusammenarbeit des Arbeitsbereichs Wissenschaftliche Weiterbildung mit dem Lehrstuhl Medienforschung und Erwachsenenbildung im Institut I der Fakultät für Humanwissenschaften der OvGU
Authors: Schröder Heike , Freymark Olaf
Published: December 2022

Seit Jahrzehnten gibt es an der Otto-von-Guericke-Universität den Arbeitsbereich Wissenschaftliche Weiterbildung. Über 20 Jahre hat Johannes Fromme diesen Bereich geleitet. In dem Beitrag wird retrospektiv die Zusammenarbeit zwischen dem Lehrstuhlinhaber und dem Arbeitsbereich behandelt. Hierbei werden einige Herausforderungen der letzten Jahre wie z. B. der Bolognaprozess thematisiert. In diesem Zusammenhang werden die Verdienste von Johannes Fromme für die Bestandssicherung und Weiterentwicklung der Wissenschaftlichen Weiterbildung gewürdigt.
A PhD fokozat értéke a gazdálkodás- és szervezéstudományok területén – 30 éves szubjektív visszatekintés
Authors: Székely Csaba
Published: December 2022

1993-ban, a felsőoktatásról szóló törvény kihirdetésével indulhatott el hivatalosan a PhD tudományos fokozattal kapcsolatos képzés a magyarországi egyetemeken. Csakhamar megjelentek a gazdálkodás- és szervezéstudományi területen képzésre jogosult, akkreditált doktori programok (később doktori iskolák). Ezek iránt (csakúgy, mint a műszaki területek iránt) a pályafutásukat nem csak a kutatási vagy felsőoktatási területen elképzelő jelöltek, hanem a gyakorlatot, a különböző intézmények és vállalkozások állásait választók is érdeklődést mutattak. A doktorképzésre jelentkezők akkor még csak reménykedhettek abban, hogy döntésük pozitív irányba fogja befolyásolni pályájukat, azaz számukra értékes lesz a tudományos fokozat megszerzése.A tanulmány 30 éves témavezetői visszatekintés alapján, 33 PhD fokozatot szerzett, és azóta különböző szakterületeken tevékenykedő egykori hallgató megkérdezésével kísérelt meg választ találni azokra a kérdésekre, amelyek ma is foglalkoztathatják a tudományos közvéleményt, de főleg a PhD képzést választani szándékozó egyetemi hallgatókat. Ha a felsőoktatásban képzelik el pályafutásukat, van-e esélyük a PhD képzés mielőbbi eredményes abszolválására, és a disszertáció megvédésére? Megéri-e a több éves továbbtanulás azoknak is, akik nem kifejezetten oktatói vagy kutatói pályát választanak? Hogy vélekednek a doktori képzéssel kapcsolatos különböző akadályokról a már tudományos fokozatot szerzettek?A tanulmány részben a szakirodalom, részben a saját felmérés alapján kíván választ adni a felvetett kérdésekre. A válaszok többsége pozitív és támogató, de nyilvánvaló eltérések is vannak a különböző szakterületek képviselői, vagy az eltérő élethelyzetek esetén.
Public opinion and influencers on social media: the valuation of their effects by generation Y and Z in Hungary Public opinion and influencers on social media
Authors: Nyikos Bendegúz Richárd
Published: December 2022

Internet technologies made it possible for organisations to reach masses of people. It has also become essential to get to know the right audience in order to achieve a better return on their investments in marketing campaigns. However, with the ever-changing world and fast-paced evolution of digital technologies the consumer preferences have also altered. Digital communication is mostly used by the younger generations. Even though in terms of their age there are also a slight difference between generation Y and generation Z, there are significant differences between them based on their consumption habits. The internet and the available forums allow people to express their feelings. With the introduction of social media virtually anybody can let their peers and the public know how they value different things, goods, services or, as in fact, also companies. Additionally, the various digital platforms and social media has brought the term “influencer” into life: a form of opinion leaders have born whose power can also be leveraged by the companies. However, it must also be taken into account that there might be differences in the reaction of the different cohort: this research aims to discover how the generation Y and generation Z in Hungary values the effects of the opinion of both consumers or the well-known public figures.
Hydraulic modeling approach for evaluating the performance of flow-starved water transmission networks
Authors: Sinha Abhishek Kumar , Ghorpade Anujkumar , Damani Om , Kalbar Pradip P.
Published: December 2022

The planning and design of water networks in water supply systems are primarily based on demand-driven modeling. The prevailing design provisions, such as minimum diameter, lead to oversizing of the water network, affecting operation. In upstream balancing reservoirs, outflow due to the water transmission network's excessive withdrawal capacity surpasses the available inflow causing flow starvation under intermittent water supply. This flow starvation causes partial flow in the downstream vicinity and forms a standing water column in the balancing reservoir's immediate downstream pipe. Traditional modeling approaches cannot simulate the piped network performance under this phenomenon due to their inability to model partial flow. Hence, a novel modeling approach is developed using a tank with an irregular cross-section, which integrates the hydraulic performance of the tank and the downstream pipe. Additionally, a reservoir and control valve represent the water withdrawal mechanism at the downstream reservoir. The proposed modeling approach simulates performance of a flow-starved water transmission network. A case study based on a real network is used to illustrate the robustness of the proposed approach. The developed modeling approach can serve as a management tool to devise operation schedules, helping better manage the operations of the water networks.
Surface-groundwater exchange between a wetland, sandur, and lava field in southeastern Iceland
Authors: Aggarwal Aiesha , Young Kathy L.
Published: December 2022

In May 2019, over 50 springs were identified at a sandur-lava field–wetland complex in Southeast Iceland and a subset was selected for further investigation including monitoring water levels, discharge, and water chemistry. Between May and September 2019, springs at the study site had relatively stable water levels and temperatures (4–5 °C), although heavy rains (>10 mm) corresponded with increased water levels and/or temperatures at some springs. Together, the water level, temperature, and stable isotope data suggest that the springs at the study site are fed by older groundwater from an aquifer that is recharged by precipitation. Spikes in water level indicated that at least one spring at the edge of the sandur also received floodwater and shallow subsurface flows from the glacial-fed Brunná River. One wetland spring was further monitored over the water year (October 2019 to October 2020). Like other springs, water levels and temperatures remained relatively stable, fluctuating with inputs of precipitation. Longer-term studies will be needed to gain an improved understanding of seasonal spring vulnerability to climate change and their role in the functioning of a coastal wetland in Southeast Iceland.
Low-concentration methanol effect on the microorganisms, nitrogen removal, and recovery of the completely autotrophic nitrogen removal over nitrite
Authors: Yue Xiu , You Ao , Liu Yang , Lai Mincheng , Zhang Kun
Published: December 2022

Methanol has a significant effect on the performance of the completely autotrophic nitrogen removal over the nitrite (CANON) process. In this research, the effect of low-concentration methanol on the functional microorganisms and nitrogen removal and recovery in the CANON system is investigated. The result shows that the anaerobic ammonium-oxidizing bacteria (AnAOB) was suppressed with low-concentration methanol addition, and the phylum Planctomycetes was hidden. The genus Candidatus Brocadia was restrained, and the relative abundances reduced from 25.5 to 15.0% in the upper biofilm and from 20.3 to 14.3% in the bottom biofilm, respectively. However, low-concentration methanol promoted the nitrifying oxidizing bacteria (NOB) activity. This phenomenon reduced the average ammonium nitrogen removal rate from 95.0 to 70.7%, and the average total nitrogen removal rate decreased from 81.3 to 43.6%, respectively. The results demonstrated that the low-concentration methanol as an organic carbon matter harmed the CANON process. Fortunately, the CANON system had an excellent self-healing ability when the methanol was stopped, with the average ammonium nitrogen removal rate and total nitrogen removal rate returning to 95.5 and 80.9%, respectively. This research supplies a reference for practical engineering design and application by improving the understanding of the effects of low-concentration methanol on CANON process performance.
Microplastic discharge from a wastewater treatment plant: long term monitoring to compare two analytical techniques, LDIR and optical microscopy while also assessing the removal efficiency of a bubble curtain
Authors: Bäuerlein Patrick S. , Pieke Eelco N. , Oesterholt Frank I. H. M. , ter Laak Thomas , Kools Stefan A. E.
Published: December 2022

In this study we compare two parallel analytical methods while also testing a microplastics mitigation method. We assess the effectiveness of a bubble curtain to reduce microplastics in a wastewater treatment plant (WWTP)-effluent canal during the course of six months (>70 samples) using two analytical techniques: laser direct infrared (LDIR) and optical microscopy (OM) covering a size range of 0.02 to 5 mm. Comparison of the two analytical strategies shows similar trends, fluctuations, and correlating particle and fibre numbers. However, absolute values of particles differ, and the strategies provide different levels of information: LDIR is capable of identifying the plastic type as well as shape, while OM cannot determine the plastic type. Furthermore LIDR has a lower size limit (10–20 μm) than OM (50 μm). While information obtained by OM in general is far less detailed it is more affordable. This research also shows that the bubble curtain pilot does not have a measurable effect on the particle concentration. Possible effects of the curtain are hidden in the temporal variations. This research also reveals that individual samples show a large variation in particle numbers, illustrating that single measurements might give a poor representation of environmental particle number.
Współczesne koncepcje cyklicznej zmiany społecznej
Authors: Bieńkowski Mateusz
Published: December 2022

Przedmiotem artykułu jest zagadnienie cyklicznej zmiany społecznej zawartej w koncepcjach dwudziestowiecznych badaczy. Zmiana społeczna może być ujęta w formie powtarzającego się cyklu lub w sposób linearny. W pierwszym przypadku przebiega ona w taki sposób, że bieg wydarzeń powraca po jakimś czasie do punktu początkowego. Koncepcja cyklicznej zmiany społecznej ma długie tradycje sięgające antyku, jednak na przestrzeni stuleci podejście to nie znalazło wielu kontynuatorów. Celem niniejszej pracy jest nie tylko zaprezentowanie współczesnych teorii cyklicznych, ale także analiza mechanizmów podziału cykli. Zostaną w niej zbadane teorie Oswalda Spenglera oraz Arnolda Toynbee opisujące mechanizmy zmiany w odniesieniu do cyklu rozwoju oraz upadku cywilizacji oraz najbardziej uznane socjologiczne koncepcje cykliczne autorstwa Vilfredo Pareto oraz Pitirima Sorokina. W artykule zostaną także przeanalizowane dwie teorie cykliczne z przełomu XX i XX I w. Koncepcja cyklu pokoleniowego Neila Howe’a i Williama Straussa oraz koncepcja cykli sekularnych Piotra Turchina. Istotne jest także porównanie wskazanych teorii z dwudziestowiecznymi uznanymi w socjologii koncepcjami cyklicznymi.
Studi Penilaian Kinerja Sistem Irigasi dengan pendekatan permen PUPR No.12/PRT/M/2015 dan PSETK untuk prioritas penanganan dengan metode AHP pada Daerah Irigasi Kaligawe kabupaten Klaten.
Authors: Prasetyaningrum Ndaru , Prayogo Tri Budi , Sayekti Rini Wahyu
Published: December 2022

Untuk memaksimalkan pemanfaatan sumber daya air di bidang pertanian di DI Kaligawe perlu diadakan Penilaian Kinerja Irigasi. Dalam penelitian ini memakai metode Penilaian Kinerja Irigasi Permen PUPR No. 12/PRT/M/2015 dan PSTEK (Profil Sosial Teknik Ekonomi Kelembagaan), untuk menetukan skala prioritas penangan menggunakan metode AHP (Analytical Hierarchy Process) dengan bantuan paket program Super decission 2.10.Hasil Penilaian dengan Metode Permen PUPR No. 12/PRT/M/2015 Indeks Kinerja sebesar 82,57% , yang terdiri dari aspek Prasarana Fisik 37,67%, Produktitas Tanam 13,88%, Sarana Penunjang 5,69%, Organisasi Personalia 12,90%, Dokumentasi 3,85%, P3A 8,575%.Dengan Metode PSETK skoring Profil Sosial sebesar 12 (Tinggi), skoring Profil Ekonomi sebesar 8 (Tinggi), skoring Profil Teknik 30 (Baik), skoring Profil Kelembagaan 17 (Cukup Baik).Prioritas penanganan dengan metode AHP bersumber dari Permen PUPR No. 12/PRT/M/2015 adalah Prasarana Fisik(0,171), sub-aspek Bangunan Utama (0,136).Prioritas penanganan dengan metode AHP berdasarkan PSETK adalah Profil Teknik (0,246).
Studi Perencanaan Konstruksi Bendungan Cijurey Tipe Beton Padat Gilas Gravitasi Kecamatan Sukamakmur Kabupaten Bogor Jawa Barat
Authors: Fazjrin Muhammad Rafi , Marsudi Suwanto , Dermawan Very
Published: December 2022

The design of the Cijurey Dam with Gravity Roller Compacted Concrete Type aims to hold back the flow, drain the water, and raise the water level. The spillway built in the Cijurey Dam is an overflow type located in the middle of the dam. The initial stage of this study is calculating the curvature of the reservoir capacity which is then used for flood routing on the spillway. The result of flood routing is in the form of outflow which will be used as the basis for planning the width of the spillway, the water level profile, and the planning of the stilling basin. Then an analysis of the stability of the overflow and non-overflow dam body was carried out, and the retaining wall on the spillway and stilling basin. Next is the calculation of the load for determining the diameter of the reinforcement in the structure. From this study it was found that the spillway on the Cijurey Dam can flow Q100th and Q1000th discharges. Then for the retaining wall on the spillway and stilling basin, it is designed to use a cantilever type retaining wall. Furthermore, the analysis of the stability of rolling, shearing, and bearing capacity on the Cijurey Dam and retaining walls on the spillway and stilling basin have met the requirements. In the construction of dams and retaining walls, concrete with a quality of f'c = 25 MPa and fy = 400 MPa is used.Perencanaan Bendungan Cijurey Tipe Beton Padat Gilas Gravitasi bertujuan untuk membendung aliran, mengalirkan air, dan meninggikan muka air. Pelimpah yang dibangun di Bendungan Cijurey berjenis overflow yang berada di tengah bendungan. Tahapan awal dari studi ini yaitu menghitung lengkung kapasitas waduk yang selanjutnya digunakan untuk flood routing pada pelimpah. Hasil dari flood routing berupa outflow yang akan digunakan sebagai dasar perencanaan lebar pelimpah, profil muka air, serta perencanaan peredam energi. Kemudian dilakukan analisis stabilitas tubuh bendungan bagian overflow dan non â€“ overflow, dan dinding penahan pada peluncur dan peredam energi. Selanjutnya adalah perhitungan pembebanan untuk penentuanÂ diameter tulangan pada struktur. Studi ini menghasilkan analisis bahwa pelimpah pada Bendungan Cijurey dapat mengalirkan debit Q100th dan Q1000th. Kemudian untuk dinding penahan pada peluncur dan peredam energi didesain menggunakan dinding penahan tipe cantilever. Selanjutnya analisis stabilitas guling, geser, dan daya dukung pada Bendungan Cijurey dan dinding penahan pada peluncur serta peredam energi telah memenuhi persyaratan. Pada konstruksi bendungan dan finding penahan digunakan beton dengan mutuÂ Â f'c = 25 MPa dan fy = 400 MPa.
Studi Manajemen Proyek Rehabilitasi Daerah Irigasi Domas Kabupaten Pasuruan Menggunakan Metode Crashing dan Fasttrack
Authors: Putra Arya Pradamansyah , Cahya Evi Nur , Fidari Jadfan Sidqi
Published: December 2022

Penerapan manajemen konstruksi diperlukan untuk menindaklanjuti penyimpangan yang terjadi pada proyek. Penelitian dilakukan pada proyek pemerintah Rehabilitasi Daerah Irigasi Domas, Kabupaten Pasuruan yang terindikasi mengalami adanya deviasi keterlambatan proyek. Tujuan dalam penelitian ini akan dibahas penggunaan metodeÂ Earned Value AnalysisÂ sebagai estimasi durasi akhir proyek serta analisa perecepatan proyek menggunakan metodeÂ CrashingÂ danÂ FasttrackÂ agar dapat kembaliÂ on-track. Alternatif yang digunakan pada percepatanÂ CrashingÂ menggunakan penambahan jam lembur, sedangkanÂ FasttrackÂ dengan memparalelkan hubungan pekerjaan. Pada perhitungan metodeÂ Earned Value Analysis,Â dilakukan titik pemantauan pada minggu ke-7 dan ke-11. Didapatkan hasilÂ Schedule Performance IndexÂ (SPI) masing-masing sebesar 0,507 dan 0,751. Hal ini menandakan bahwa proyek mengalamiÂ schedule overrunÂ atau ketidakefektifan karena hasil SPI kurang dari satu. Kemudian, dari hasil tersebut, dilakukan perhitunganÂ Estimation Completion DateÂ (ECD) pada titik pemantauan dengan masing-masing hasil -70,66% dan -18,95% terhadap durasi normal jika performa proyek tetap. Maka dari itu, dilakukan perhitungan percepatan dengan metodeÂ CrashingÂ yang dimulai pada minggu ke-11 dengan hasil efektivitas durasi sebesar 23,33% dan efisiensi biaya sebesar 14,24%. Berbeda dengan percepatan metodeÂ FasttrackÂ yang dimulai pada minggu ke-7 didapatkan efektivitas durasi sebesar 16,03% dan efisiensi biaya sebesar 14,43%.Â Implementation of construction management is needed to follow up on deviations that occur in the project. The research was conducted on the government project for the Rehabilitation of the Domas Irrigation Area, Pasuruan Regency which indicated that there was a deviation from project delays. The purpose of this study will be to discuss the use of the Earned Value Analysis method as an estimate of the final project duration and analysis of project acceleration using the Crashing and Fasttrack methods so can be back on track. The alternative used in the acceleration of Crashing is to add overtime hours, whereas Fasttrack is to parallelize the task dependencies. Monitoring points are performed in the Earned Value Analysis method calculation at the 7th and 11th weeks. The Schedule Performance Index (SPI) results are 0.507 and 0.751, respectively. Because the SPI result is less than one, this indicates that the project is experiencing a schedule overrun or ineffectiveness. Hence, based on these results, an Estimation Completion Date (ECD) is calculated at the monitoring point, with results of -70,66% and -18.95%, respectively, of the normal duration if project performance remains. Accordingly, the Crashing method was calculated at week 11 with the results of duration effectiveness is 23,33% and cost-efficiency is 14,24%. In contrast to the Fasttrack method in the 7th week, the duration effectiveness is 16,03% and the cost-efficiency is 14,43%.
Analisis Debit Banjir Rancangan dengan Metode HSS Nakayasu, HSS ITB-1, dan HSS Limantara pada DAS Manikin di Kabupaten Kupang
Authors: Damayanti Alvine Cinta , Limantara Lily Montarcih , Haribowo Riyanto
Published: December 2022

East Nusa Tenggara Province is a dry area where the rain season is relatively short and the rainfall intensity is low. This causes the production of food crops can not be maximized, even crop failure. The limited water resources in East Nusa Tenggara Province can be optimized by doing construction the Manikin Dam. In water resources planning, realistic flood discharge is needed by using the Synthetic Unit Hidrograph Method. The purpose of this research is to analyze the design flood discharge using the Methods of Synthetic Unit Hidrograph Nakayasu, ITB-1, and Limantara in Manikin Watershed of Kupang Regency. The calculation of the design flood discharge is carried out after obtaining the design rainfall value by using Normal, Log Normal, Gumbel, and Log Pearson Type III distribution methods. The results obtained are tested for suitability and the design rainfall value that passed can be use in the calculation of the design flood discharge. The results showed that the design flood discharge from the calculation of Nakayasu SUH method is 1597,16 m3/sec, that the design flood discharge from the calculation of ITB-1 SUH method is 965,64 m3/sec, and that the design flood discharge from the calculation of Limantara SUH method is 401,32 m3/sec. Based on the results, the value of the calculation of Nakayasu SUH method is the most suitable method and the closest to the conditions in the Manikin watershed.Provinsi Nusa Tenggara Timur merupakan daerah kering dimana musim basah (hujan) relatif pendek dan intensitas curah hujan yang kecil. Hal ini menyebabkan terjadinya produksi tanaman pangan tidak dapat maksimal, bahkan gagal panen. Terbatasnya sumber daya air di Propinsi Nusa Tenggara Timur dapat dioptimalkan dengan melakukan pembangunan Bendungan Manikin. Pada perencanaan bidang sumber daya air, dibutuhkan data debit banjir yang realistis dengan menggunakan Metode Hidrograf Satuan Sintetis. Penelitian bertujuan untuk menganalisis debit banjir rancangan dengan menggunakan ketiga metode Hidrograf Satuan Sintetis yaitu HSS Nakayasu, ITB-1, dan Limantara pada DAS Manikin di Kabupaten Kupang. Perhitungan debit banjir rancangan dilakukan setelah mendapat nilai hujan rancangan dengan menggunakan metode distribusi Normal, Log Normal, Gumbel, dan Log Pearson Type III. Hasil yang diperoleh diuji kembali kesesuaiannya dan nilai hujan rancangan yang lolos digunakan dalam perhitungan debit banjir Damayanti, A. C. et al., Jurnal Teknologi dan Rekayasa Sumber Daya Air Vol. 0 No. 0 (2021) p. 0-0 2 rancangan. Hasil penelitian menunjukkan bahwa nilai debit banjir rancangan perhitungan metode HSS Nakayasu sebesar 1597,16 m3 /det, debit banjir rancangan perhitungan metode HSS ITB-1 sebesar 965,64 m3 /det, dan debit banjir rancangan perhitungan metode HSS Limantara sebesar 401,32 m3 /det. Berdasarkan hasil analisis, nilai dari perhitungan metode HSS Nakayasu merupakan metode yang sesuai dan paling mendekati dengan kondisi di DAS Manikin.
Analisis Keruntuhan Bendungan Raknamo Kabupaten Kupang Menggunakan Software HEC-RAS
Authors: Purnomo Yehezkiel Christian , Asmaranto Runi , Sisinggih Dian
Published: December 2022

Raknamo Dam is a hydraulic structure built on the Noel Puames River to store and control its flow by forming a reservoir in the upstream area. Raknamo Dam, which is categorized as non-homogeneous (zoned) earth dam, was developed to supply water for domestic purposes, irrigation, micro-hydropower, recreational object, and flood control. The essential goal of this study is to discover probable failure scenarios for Raknamo Dam. Based on the hypothetical scenarios, there are two major causes of dam failure: overtopping and piping. Dam-break analysis was carried out via HEC-RAS 5.0.7 Software using various scenarios. Overtopping Scenario produces the largest inundation area that stretches up to 5030.79 hectares. The flash flood triggered by the dam failure had devastating effects on downstream areas: affected 10200 people, damaged 2682 buildings, inundated 3340 hectares cultivated land, 140.512 kilometres roads impassable, and several others followed. The downstream area suffered Rp 1,124,903,589,268.22 loss according to the assessment via Ina-SAFE approach.Bendungan Raknamo merupakan struktur hidrolis yang dibangun pada ruas Sungai Noel Puames untuk menampung dan mengatur aliran air dengan membentuk waduk di sisi hulu bendungan. Bendungan yang dikategorikan dalam jenis bendungan urugan tanah non-homogen (zonal) ini dikembangkan dalam rangka memenuhi pasokan air domestik, pemenuhan kebutuhan air irigasi, pembangkit listrik tenaga mikro-hidro, prasarana wisata, dan pengendalian banjir. Tujuan utama penelitian ini ialah mengetahui skenario kegagalan yang mungkin terjadi pada Bendungan Raknamo. Berdasarkan hipotesis, terdapat dua skenario utama yang menyebabkan Keruntuhan Bendungan Raknamo, yaitu overtopping dan piping. Analisis keruntuhan bendungan dilakukan pada Software HEC-RAS 5.0.7 dengan berbagai pendekatan skenario. Skenario Overtopping menimbulkan genangan dengan luasan terbesar yang membentang seluas 5030.79 hektar. Banjir bandang yang dipicu kegagalan bendungan meimbulkan dampak buruk pada daerah hilir: 10200 penduduk terdampak, 2682 bangunan rusak, 3340 hektar lahan cocok tanam tergenang, 140.512Â  kilometer ruas jalan tidak dapat dilalui, dan beberapa lainnya. Kerugian pada daerah di hilir Bendungan Raknamo diestimasikan mencapai Rp 1,124,903,589,268.22 hasil penilaian kerugian tersebut dilakukan dengan menggunakan Metode InaSAFE.
Preferences of Older Adult Veterans With Heart Failure for Engaging With Mobile Health Technology to Support Self-care: Qualitative Interview Study Among Patients With Heart Failure and Content Analysis
Authors: Foster Marva , Xiong Wei , Quintiliani Lisa , Hartmann Christine W , Gaehde Stephan
Published: December 2022

Background

Heart failure (HF) affects approximately 6.5 million adults in the United States, disproportionately afflicting older adults. Mobile health (mHealth) has emerged as a promising tool to empower older adults in HF self-care. However, little is known about the use of this approach among older adult veterans.

Objective

The goal of this study was to explore which features of an app were prioritized for older adult veterans with HF.

Methods

Between January and July 2021, we conducted semistructured interviews with patients with heart failure aged 65 years and older at a single facility in an integrated health care system (the Veterans Health Administration). We performed content analysis and derived themes based on the middle-range theory of chronic illness, generating findings both deductively and inductively. The qualitative questions captured data on the 3 key themes of the theory: self-care maintenance, self-care monitoring, and self-care management. Qualitative responses were analyzed using a qualitative data management platform, and descriptive statistics were used to analyze demographic data.

Results

Among patients interviewed (n=9), most agreed that a smartphone app for supporting HF self-care was desirable. In addition to 3 a priori themes, we identified 7 subthemes: education on daily HF care, how often to get education on HF, support of medication adherence, dietary restriction support, goal setting for exercises, stress reduction strategies, and prompts of when to call a provider. In addition, we identified 3 inductive themes related to veteran preferences for app components: simplicity, ability to share data with caregivers, and positive framing of HF language.

Conclusions

We identified educational and tracking app features that can guide the development of HF self-care for an older adult veteran population. Future research needs to be done to extend these findings and assess the feasibility of and test an app with these features.
Perspectives on the COVID-19 Vaccination Rollout in 17 Countries: Reflexive Thematic and Frequency Analysis Based on the Strengths, Weaknesses, Opportunities, and Threats (SWOT) Framework (Preprint)
Authors: Kopilaš Vanja , Nasadiuk Khrystyna , Martinelli Lucia , Lhotska Lenka , Todorovic Zoran , Vidmar Matjaz , Machado Helena , Svalastog Anna Lydia , Gajović Srećko
Published: December 2022

BACKGROUND

As the SARS-CoV-2 virus created a global pandemic and rapidly became an imminent threat to the health and lives of people worldwide, the need for a vaccine and its quick distribution among the population was evident. Due to the urgency, and on the back of international collaboration, vaccines were developed rapidly. However, vaccination rollouts showed different success rates in different countries and some also led to increased vaccine hesitancy.

OBJECTIVE

The aim of this study was to identify the role of information sharing and context sensitivity in various vaccination programs throughout the initial COVID-19 vaccination rollout in different countries. Moreover, we aimed to identify factors in national vaccination programs related to COVID-19 vaccine hesitancy, safety, and effectiveness. Toward this end, multidisciplinary and multinational opinions from members of the Navigating Knowledge Landscape (NKL) network were analyzed.

METHODS

From May to July 2021, 25 completed questionnaires from 27 NKL network members were collected. These contributors were from 17 different countries. The responses reflected the contributors’ subjective viewpoints on the status and details of the COVID-19 vaccination rollout in their countries. Contributors were asked to identify strengths, weaknesses, opportunities, and threats (ie, SWOT) of the respective vaccination programs. The responses were analyzed using reflexive thematic analysis, followed by frequency analysis of identified themes according to the represented countries.

RESULTS

The perspectives of NKL network members showed a link between organizational elements of the vaccination rollout and the accompanying societal response, both of which were related to strengths and weaknesses of the process. External sociocultural variables, improved public communication around vaccination-related issues, ethical controversies, and the spread of disinformation were the dominant themes related to opportunities and challenges. In the SWOT 2×2 matrix, Availability and Barriers emerged as internal categories, whereas Transparent communication and promotion and Societal divide emerged as key external categories.

CONCLUSIONS

Inventory of themes and categories inspired by elements of the SWOT framework provides an informative multidisciplinary perspective for effective implementation of public health strategies in the battle against COVID-19 or any future pandemics of a similar nature.
Effects of Developing a Mobile-based Interactive Simulation Scheme for Assisting the Personalized Hands-on Learning of Nasogastric Tube Insertion: a randomized controlled trial (Preprint)
Authors: Chen Chen-Ju , Su Jun-Ming , Wu Ming-Hsuan , Hung Shang-Yu , Hou Chia-Ling , Lee Huan-Fang
Published: December 2022

BACKGROUND

Nasogastric tube (NG) insertion is one of the essential clinical skills. Unfortunately, it’s a blind procedure, as one cannot directly visualize the tip of the NG during the insertion process. Thus, the most significant risk was malposition. Suppose blind insertion can be broken through in teaching strategies so that learners can see through the internal structure of the human body when performing technology. In that case, students can have better memory and comprehension and simultaneously provide real-time feedback, both of which are conducive to conceptualizing invasive surgical execution.

OBJECTIVE

A mobile-based interactive simulation scheme (MISS) was proposed, and a MISS-based learning system was developed to investigate its effects on facilitating hands-on learning of nasogastric tube (NG) insertion in Taiwanese undergraduate medical students.

METHODS

A randomized controlled trial (RCT) design was adopted for this research, for which 73 grade-five medical students were recruited. An interactive simulation scheme with a hands-on learning design in a MISS model was built on a web-based application running on mobile devices equipped with the touchscreen. Learning performance including the conceptual knowledge, self-confidence scales, and practical skills (an OSCE-based test) were evaluated to investigate the differences between experimental and control groups. The MISS-based learning system was also evaluated in terms of learning satisfaction, system usability, and task load. The statistical methods used in this work included t-test, ANCOVA, and the Johnson-Neyman analysis.

RESULTS

he results showed significant differences between the experimental and control groups in terms of both knowledge and self-confidence (P < .001). The levels of image, perceived enjoyment, perceived usefulness, and intention to use scales in the technology acceptance model (TAM) were higher in the high progress group than in the low progress group. Besides, the score of the OSCE test in the experimental group were higher than those in the control group, which had significant difference (t=3.079, P=.003).

CONCLUSIONS

The proposed MISS-based learning system can efficiently assist students in hands-on learning of nasogastric tube insertion. Accordingly, the learning outcomes and self-confidence can be significantly improved. Moreover, experimental results also show that the useful diagnostic and enjoyment features in the system enhance learners' intention toward use.