bluuebunny/crossref_metadata_2025 huggingface dataset:
What patients tell us: Assessing feedback and perspectives of patients with post-treatment Lyme disease symptoms.
Authors: McCarthy Meghan , Vargas Sara , Adelson-Mitty Jennifer , Johnson Jennie , P. Flanigan Timothy
Published: April 2024

While most patients with Lyme disease fully recover within 6 months, a minority of patients develop significant and persistent symptoms after appropriate antibiotic treatment. With no clear pathophysiology or treatment, post-treatment Lyme disease (PTLDS) (also sometimes referred to as chronic Lyme) is a highly contested condition within the medical community. After conducting a phone survey of 25 patients who had visited an outpatient, academic center for Lyme and other tick-borne diseases, we collected and summarized patients’ perspectives and feedback of the care they received for ongoing Lyme-related symptoms. Findings from this phone survey demonstrated an extremely varied history with regards to experiences with diagnosis, treatment, and management of long-term symptoms. Key themes include a wide-ranging but life-altering self-reported symptomatology, pervasive doubts/frustrations in the medical system regarding treatment of PTLDS symptoms, and how often patients tried unconventional and nontraditional treatment methods. Importantly, patients were unified in their appreciation for an approachable and validating healthcare team even if they did not find complete resolution in their symptoms.
Efficacy of ICD in ischemic cardiac disease determined by reconstructing patient-level data from Kaplan-Meier survival curves
Authors: Messori Andrea , Rivano Melania , Spazio Lorenzo , Trippoli Sabrina
Published: April 2024

Background: Implantable cardioverter defibrillators (ICDs) are indicated for the prevention of sudden death in ischemic heart disease. Four randomized trials are the main source of efficacy data. Aims and Methods: Reconstruction of patient-level data from survival curves is a new technique (called the Shiny method or IPDfromKM method) for studying effectiveness. We used this method to analyze the four afore-mentioned trials based on the endpoint of all-cause mortality. After reconstruction by the IPDfromKM method, patient-level data were pooled according to three therapeutic options: ICDs, medical therapy, and no active treatment. Standard statistical comparisons were then made between these three groups of patients. Time-to-event data for reconstructed patients were evaluated using standard Kaplan-Meier analysis. The hazard ratio was estimated to compare and interpret these survival data. Results: A total of 4,621 patients were enrolled (follow-up, 60 months). Of these, 1,827 were treated with ICDs and 1,493 received medical therapy; the control group included 1,301 patients who received no active treatment. Our analysis, based on pooled Kaplan-Meier curves, showed that ICD was the most effective, followed by medical therapy and no active treatment. ICD was associated with significantly better survival compared with medical therapy (hazard ratio, 0.6523; 95% confidence interval [CI], 0.5580 to 0.7622; p<0.001) and no active treatment (hazard ratio, 0.6340; 95%CI, 0.5417 to 0.7424; p<0.001). In the subgroup of patients receiving an ICD, the heterogeneity between trials was negligible, whereas it was significant in the subgroups receiving medical therapy or no active treatment. Conclusions: Our results provide original evidence on long-term survival in ischemic heart disease. Methodologically, our study confirmed the advantages of the Shiny method.
Advancements in Molecular Imaging for the Diagnosis and Management of Hepatocellular Carcinoma
Authors: Gheisari Farshid , Vali Reza
Published: April 2024

Hepatocellular Carcinoma (HCC) is a growing global health burden with high incidence and mortality rates. Despite advances in surgical techniques and perioperative care, outcomes after surgical treatment have not improved over the past three decades. Molecular imaging is an emerging field that enables researchers to study diseases at the molecular and cellular levels, enabling the detection of elevated serum α-fetoprotein (AFP) and abnormal expressions of various HCC-specific and nonspecific cell surface antigens and intracellular targets. Molecular imaging techniques detect liver lesions at the molecular and cellular level, allowing early detection and accurate staging of HCC. Positron emission tomography (PET) imaging offers greater sensitivity and specificity, while hepatobiliary-specific radiotracers with SPECT imaging provide insights into benign and malignant lesion differentiation. Radiomics and artificial intelligence are vital in deciphering molecular imaging data, with machine learning algorithms boosting diagnostic gains and predicting treatment response. Theranostics, a state-of-the-art application, provides diagnostic and therapeutic leverage following a single imaging agent. By understanding tumor biology in real time, radiopharmaceuticals can be transformed into personalized radiotherapies, enabling clinicians to make science-driven decisions throughout the illness. Future directions include developing novel radiotracers and integrating AI into clinical decision-making. Collaboration between academic researchers, clinicians, and industry colleagues is crucial to converting exciting advances into improved clinical outcomes for HCC patients.
FEATURES OF THE SYSTEM OF INTER-BUDGETARY RELATIONS IN THE RUSSIAN FEDERATION
Authors: Белаш А.В.
Published: April 2024

В статье рассмотрены и проанализированы теоретические и прикладные аспекты развития межбюджетных отношений в  России, проблемы распределения властных полномочий через межбюджетные отношения. На основании выявленных тенденций обозначены основные разновидности межбюджетных трансфертов и их место в системе межбюджетных отношений. Особое внимание уделено структуре и динамике межбюджетных трансфертов бюджетам субъектов РФ согласно основным направлениям бюджетной, налоговой и таможенно-тарифной политики на 2020 год и на плановый период 2021 и 2022 гг. (утв. Минфином России). В результате исследования определяется воздействие каждого вида межбюджетного трансферта на социально-экономическое развитие публично-правовых образований и тем самым обосновывается важность экономического выравнивания социально-экономического развития регионов и роль политики межбюджетных отношений в этом процессе. Помимо этого, выявлены основные проблемы и недостатки в системе межбюджетных отношений РФ.

The article examines and analyzes the theoretical and applied aspects of the development of inter-budgetary relations in Russia, the problems of the distribution of power through inter-budgetary relations. Based on the identified trends, the main types of inter-budgetary transfers and their place in the system of inter-budgetary relations are identified. Special attention is paid to the structure and dynamics of inter-budget transfers to the budgets of the constituent entities of the Russian Federation according to the main directions of budget, tax and customs tariff policy for 2020 and for the planning period of 2021 and 2022 approved by the Ministry of Finance of the Russian Federation. As a result of the study, the impact of each type of inter-budgetary transfer on the socio-economic development of public legal entities is determined, and thus the importance of economic alignment of the socio-economic development of regions and the role of the policy of inter-budgetary relations in this process is substantiated. In addition, the article identifies the main problems and shortcomings in the system of inter-budgetary relations of the Russian Federation.
METHODS FOR EVALUATING INNOVATIVE PROJECTS WITH VENTURE FINANCING
Authors: Смирнов Н.А.
Published: April 2024

В статье рассмотрены и проанализированы методологические подходы к  оценке финансового состояния и вероятности дефолта стартапов, позволяющие определить инвестиционную привлекательность инновационных проектов как для основателя стартапов, так и для инвестора. На основании выявленных тенденций изложены краткие характеристики представленных методов, в том числе обозначены основные группы показателей, которые обычно используются венчурными фондами для оценки стартапов. Особое внимание уделено критериям, которые влияют на стоимость стартапа, и внешним факторам (рыночные силы отрасли и сектора). В результате исследования показана экономическая целесообразность применения того или иного метода на различных стадиях инновационных проектов, а также обозначены и систематизированы ключевые преимущества и ограничения применяемых инструментов оценивания инновационных проектов.

The article analyzes methodological approaches to assessing the financial condition and probability of startup default, which allow determining the investment attractiveness of innovative projects both for the founder of startups and the investor. Based on the identified trends, brief characteristics of the presented methods are outlined, including the main groups of indicators that are usually used by venture funds to evaluate startups. Special attention is paid to the criteria that affect the startup’s value and external factors (market forces of the industry and sector). As a result of the study, the article shows the economic feasibility of using a particular method at various stages of innovative projects and identifies and systematizes the key advantages and limitations of the used tools for evaluating innovative projects.
ARTIFICIAL INTELLIGENCE AS A SUBJECT OF LAW: ARTIFICIAL INTELLIGENCE’S DELICTUAL DISPOSITIVE CAPACITY
Authors: Медведев Д.А.
Published: April 2024

Современные ИИ-технологии развиваются стремительно. Системы с искусственным интеллектом активно внедряются в нашу жизнь, а сам искусственный интеллект становится полноправным субъектом общественных отношений. Являясь социальным институтом, право не может игнорировать появляющиеся новые формы взаимодействия в обществе. Традиционно искусственный интеллект занимал место объекта правовых отношений, однако мы наблюдаем его развитие  – появление у  искусственного интеллекта признаков субъекта правовых отношений. Идея признания искусственного интеллекта в качестве субъекта права активно обсуждается и является предметом рассмотрения данной статьи. Признание правосубъектности искусственного интеллекта могло бы стать значительным шагом в  определении и  регулировании соотношения прав и обязанностей между субъектами права и искусственным интеллектом, что, несомненно, потребует серьезных изменений в законодательстве, системе образования и общественном восприятии искусственного интеллекта.

Modern AI technologies are rapidly developing. Systems with artificial intelligence are being actively introduced into our lives, and artificial intelligence itself is becoming a full-fledged subject of public relations. As a social institution, law cannot ignore emerging new forms of interaction in society. Traditionally, artificial intelligence occupied the place of an object of legal relations, but over time we observe its development, namely the appearance in artificial intelligence of features of a subject of legal relations. The idea of recognizing artificial intelligence as a subject of law is the subject of this article. Recognition of the legal personality of artificial intelligence could be a significant step in defining and regulating the relationship of rights and obligations between subjects of law and artificial intelligence, which will undoubtedly require major changes in legislation, the education system and public perception of artificial intelligence.
Legal Considerations Judex Factie Acquittal and Guilty Judgments by Judex Juris
Authors: Abdaud Faisal , Umar Wahyudi , Rustan Ahmad , Ming-Hsi Sung
Published: April 2024

The corruption case involving the former North Konawe regent, Aswad Sulaiman, was acquitted by the Kendari Corruption Court in 2017, according to decision Number 56/Pid.Sus-TPK/2016/PN.Kdi. While the Supreme Court Cassation decision number 1964 K/PID.SUS/2017 decided that Defendant Aswad Sulaiman was proven legally and convincingly guilty of committing a crime by jointly committing an ongoing criminal act of corruption, imposing a prison sentence of 6 years and an IDR 200 million fine. If not paid, it will be replaced with imprisonment for 6 months, punished for producing a compensation of IDR 3,310,639,545 (three billion three hundred ten million six hundred thirty-nine thousand five hundred and forty-five rupiah). This study focuses on the legal ratio of the panel of judges in imposing an acquittal in the corruption case Number 56/Pid.Sus-TPK/2016/PN.Kdi and decision number 1964 K/PID.SUS/2017. This study used normative legal research with a statutory approach and a case approach, Law Number 31 of 1999 concerning the Eradication of Criminal Acts of Corruption, which was last amended by Law Number 20 of 2001. The results are that the recovery of state financial losses must be investigated as the starting point that the defendant has committed corruption by not releasing him from criminal responsibility but only as a basis for mitigating considerations for the defendant. The judges deciding this case have at least gone through 3 stages: constating, qualifying, and constituting.
Pertanggung Jawaban Hukum Pihak Ekspedisi Pengiriman Terhadap Barang Hilang atau Rusak
Authors: Prasetyo Edy , Budiono Arief , Sybelle Jan Alizea
Published: April 2024

There are no clear provisions in the regulations that regulate the extent to which the delivery service is responsible for losses suffered by consumers for goods sent that are damaged or lost and the uncertainty of the obligations and fines imposed by the delivery service when it does not fulfill the promise of timely delivery becomes separate problem for consumers. This study aims to determine the accountability and efforts that can be made by consumers in the case of lost or damaged goods at PT. Tri Adi Together (Anteraja). This research is a normative juridical research using deductive thinking method. Data collection techniques were carried out by interviewing and library documents. This study uses a qualitative approach in analyzing the data that has been obtained: The results show (1) there are two forms of responsibility that have been carried out by PT. Tri Adi Bersama (Anteraja) in the case of lost or damaged goods, namely providing compensation to the owner of the goods and being responsible for unlawful acts committed by its employees. (2) There are efforts that can be made by consumers to demand the responsibility of PT. Tri Adi Bersama (Anteraja) for objects sent in the event of a loss, including efforts to pass the Consumer Dispute Settlement Agency (BPSK) with arbitration, conciliation and mediation as efforts made outside of court as well as filing lawsuits, examinations and verification as efforts through legal channels.
Pencegahan Pelanggaran Tindak Pidana Pemilu melalui Pendaftaran dan Verifikasi Partai Politik Berdasarkan Undang-Undang Pemilu
Authors: Fauzi Muhammad Oky , Prasetyoningsih Nanik
Published: April 2024

After 24 years of reform, the people passionately anticipate direct general elections as a process of power transition and evaluation of the performance of political parties over the previous five years. Similarly, the registration and verification phases of political parties participating in the 2024 Election, which began on Friday, July 29, 2022, and ended on Tuesday, December 13, 2022, have concluded for the 2024 Election. The requirement for verification of political parties is an effort to improve the institutions of political parties to make them more professional in their management, as well as to verify the readiness and fulfillment of the requirements of political parties, both new and those that have participated in previous elections. In addition, if the registration and verification of political parties process proceeds smoothly, the subsequent stages will also go smoothly. One is to minimize or prevent violations of election criminal acts that can diminish the wisdom and efficiency of the 2024 Election process and stages. This study uses normative and empirical research methods and qualitative analysis to examine the relationship between the registration and verification of political parties and efforts to prevent election crime violations. This study demonstrates that verifying political party candidates can assist electors in selecting credible and competent public officials. However, verification provisions and procedures can increase the chance of election crimes and electoral misconduct. Therefore, the election commission (KPU) and Bawaslu must be resolute and unaffected by any interference that could harm the integrity of elections and democracy. The community is also responsible for supervising and providing aspirations so that election regulations do not diminish enthusiasm for conducting elections with integrity.
Comparison of Effect of Clonidine Added to Bupivacaine-Fentanyl Mixture on the Quality of Spinal Anaesthesia and Peri-Op Analgesia with Bupivacaine-Fentanyl or Bupivacaine-Clonidine Mixture in Major Orthopaedic Lower Limb Surgeries
Authors: Shah Milin Raju , Diwan Gauri
Published: April 2024

Introduction: With side effects of central neuroaxial opioids or of high dose intrathecal clonidine in combination with bupivacaine in spinal anaesthesia, my study is to ascertain if small dose of clonidine when added to bupivacaine-fentanyl mixture improves spinal anaesthesia, without producing side effects, as compared to bupivacaine-fentanyl or bupivacaineclonidine mixture. Methods: It's a prospective, double blinded randomised study of 90 ASA grade I-II patients, aged between 20-60 yrs, of either sex, weighing between 40-70 kgs, scheduled for major orthopaedic surgeries. Patients were randomly divided into 3 groups of 30 patients each as Group I (BCF): Bupivacaine 0.5%H 2.6ml + Fentanyl 20mcg + Clonidine 30mcg Group II (BC): Bupivacaine 0.5%H 2.6ml + Clonidine 30mcg Group III (BF): Bupivacaine 0.5%H 2.6ml + Fentanyl 20mcg Duration of sensory and motor blockade and effective analgesia mean time till two segment regression, haemodynamic profile, post-op pain and analgesia requirement were recorded. Results: The duration of sensory and motor blockade, effective analgesia and mean time till two segment regression were significantly longer in group BCF as compared to group BC (P – 0.002) and in group BC as compared to group BF (P – 0.01). The incidence of intra-op pain and requirement of postop analgesia in the first 24 hours was significantly more in group BF as compared to other groups (P-0.01). Conclusion: Low dose Clonidine when added to Bupivacaine-Fentanyl mixture improves the quality of peri-op analgesia without significant side effects.
Sputum Characteristics among "Chillum” Smoking ‘Sadhus' of Kumbh Mela
Authors: Dugad Sushama , Bhandare Pankaj , Kulkarni Gauri , Patil Sunil
Published: April 2024

A chillum consist a mixture of Cannabis and tobacco.Cannabis, also known as marijuana; it is a psychoactive drug from the Cannabis plant intended for medical or recreational use; nowadays widely being abused for getting high and temporary relaxation. Sputum examination of chillum smokers may indicate harmful effects of chillum smoking on lungs. Objectives of present study were to study the sputum characteristics and differential cell count of chillum smoking Sadhus of Kumbh Mela. Present descriptive observational study was conducted among fifty Sadhus of Kumbh Mela of Nashik. Participants were selected using purposive sampling method. In present study all sputum samples showed raised differential cell count and statistically significant association was observed between differential cell like Neutrophils, Lymphocytes and Macrophages with different content present in chillum.
A Prospective Study of Laparoscopic Appendicectomy for the Treatment of Acute Appendicitis
Authors: Sorate Yamini , Joshi Dinesh , Pawar Suhas
Published: April 2024

Aims and Objective: To study the efficacy, safety and clinical outcome of patients undergoing laparoscopic appendicectomy in the treatment of acutely inflamed appendix. Materials and Methods: Laparoscopic Appendicectomy is used as day to day procedure for acute appendicitis. Case study of 42 patients undergoing laparoscopic appendicectomy is studied in prospective data analysing duration of intraoperative time, complications during surgery, after surgery complications, time until resumption of orals, joining back to work, postoperative debility and length of hospital admission. Results: Total 42 patients underwent laparoscopic appendectomy 21 were male and 21 were female with the mean age of patient undergoing laparoscopic appendicectomy was 26.66 years. Pain in abdomen was most common symptom followed by nausea. All patients were discharged at around second day. Conclusion: Laparoscopic appendicectomy patients were admitted for lesser duration and their post operative pain was of less intensity. Patients of laparoscopic appendicectomy were started oral diet earlier.
Effect of Residents’ Attitude on their Perceived Effects of Tourism and Support for Sustainable Tourism
Authors: Biju T. , Gopal Biju , Kumar A. D. Rajeev , Sanu F.
Published: April 2024

Amidst sustainable tourism gaining momentum globally, the present study analyses the effect of perceived positive and negative effects of tourism on the support for sustainable tourism among the resident community at an internationally renowned responsible tourism destination, Kumarakom in Kerala. Data collected through a structured questionnaire from 276 respondents residing in and around the destination was used for analysis. Based on a comprehensive review, a theoretical model depicting the relationship between the variables of interest was developed for empirical validation. Appropriate constructs for the model were identified through Exploratory Factor Analysis (EFA). Then, Confirmatory Factor Analysis (CFA) was performed to evaluate the measurement model validity. Structural Equation Modelling employing the Partial Least Squares (PLS) method was applied to test the hypothesized model. The study established a significant effect of residents’ perception of the positive and negative effects of responsible tourism on their support for tourism development. The study provided evidence for the negative effect on residents’ perception of the adverse effects of tourism on support for tourism development. The study provides essential inputs for planners and policymakers in realigning sustainable tourism initiatives in such a way as to garner the support of the resident community. It also empirically validates a theoretical model outlining how the perception of residents on the positive and negative effects of tourism influences their support for sustainable tourism.
Volatility Linkages in Commodity Futures Markets: Evidence from the Rubber Futures Market in India
Authors: Narayanan P. , Sebastian T. K. , Karunakaran N.
Published: April 2024

The volatility spill-over effect of the commodity futures markets has been a matter of debate ever since the establishment of futures markets in India. The apprehensions regarding the price destabilizing role of futures trade called for overcautious regulatory supervision. The actions like suspension of contracts, bans on futures trade in certain commodities, and restrictions on trade volumes were very frequent; making the growth of the commodity futures market a chequered one. The Expert Committee appointed in 2007 to examine the effect of futures trade on commodity prices failed to make any categorical remark partly on account of the absence of long-term data. A commodity-specific analysis is much warranted as the price effect of the futures trade varies across the markets. The paper examined the volatility spill-over effect of the rubber futures market using a bivariate GARCH model with BEKK parameterization and found that there is no positive volatility spill-over from futures to spot. The weak linkage between futures trade and futures price variation further strengthens the finding. The absence of volatility spill-over from futures to spot in the case of rubber is due to the failure of the futures market to lead the spot market in pricing the commodity.
Travel Motivation Among Millennials- Role of Social Media on Tourism in Madhya Pradesh
Authors: Kishnani Namrata , Sharma Vivek
Published: April 2024

The emergence of new internet-enabled technologies and social media, with increasing usage of smartphones, have transformed communication in the tourism industry. Social media has enabled tourists to search, share, and co-create tourism-related content. It has become one of the potential sources for tourists to plan, organize, and fulfill their expectations. The following paper aims to explore the role of social media on tourists’ intentions to visit tourist destinations in Madhya Pradesh. The research design explores already available and published reading materials along with performing a primary data survey. The study collects responses from 170 tourists through a structured questionnaire. Analysis of the same was conducted using descriptive techniques like percentages, charts, and F test based on gender in Excel. The key findings reveal a strong influence of social media on tourism and travelers who primarily rely on social media for information searches and planning their vacations. Destination managers and travellers being the primary stakeholders have been using social media for co-creating (e-word of mouth), sharing, and disseminating tourism experiences that have led to the emergence of new business models. The study aims to assist tourism destination managers in managing their online communications to enhance their customer loyalty and destination branding through customer engagement and retention through social media marketing applications. The research study will offer unique dimensions for the extensive use of social media marketing for tourism destination image and tourist intention.
Mastering the Market Cycle – Getting the Odds on Your Side
Authors: Hariharan Vasumathy S.
Published: April 2024

No Abstract.
Editorial
Authors: Venkatraja B.
Published: April 2024

No Abstract.
Анализ напряженного состояния элементов рабочего оборудования мелиоративных машин
Authors: Абдулмажидов Х.А.
Published: April 2024

Разработка, конструирование и модернизация элементов рабочего оборудования мелиоративных машин сопряжено с изменением массы, нагрузок материалов и требует проведения анализа напряженного состояния. Целью анализа напряженного состояния или прочностного расчета является определение запаса прочности исследуемой конструкции.
Глобальные тенденции в разведке и добыче сланцевого газа: вызовы и возможности
Authors: Гулевич А.И.
Published: April 2024

Статья рассматривает современные мировые тенденции в разведке и добыче сланцевого газа, выявляя ключевые вызовы и перспективы, связанные с этим инновационным методом добычи природного газа. Автор анализирует технологические инновации и методы, применяемые в различных странах для извлечения сланцевого газа, а также рассматривает влияние этого процесса на экологические, социальные и экономические аспекты. Статья также оценивает глобальные перспективы развития сланцевой газовой промышленности, обсуждая возможности сотрудничества между странами и предлагая рекомендации для устойчивого и эффективного развития этого важного сегмента энергетического рынка.
Исследование методов переработки нефтепродуктов
Authors: Гулевич А.И.
Published: April 2024

Эта работа фокусируется на изучении последних достижений в области переработки нефтепродуктов. Основное внимание уделяется новейшим технологиям, направленным на увеличение эффективности процессов переработки и снижение негативного воздействия на окружающую среду. Методы, такие как гидроочистка, термокаталитический крекинг и гидродесульфурация, подвергаются детальному анализу в контексте их технологических преимуществ и экологических последствий. Работа направлена на выявление современных тенденций и инноваций в области переработки нефтепродуктов.
Инновации в техническом обслуживании нефтепроводов: современные подходы и технологии
Authors: Моисеев С.А.
Published: April 2024

Статья рассматривает последние технологические разработки, применяемые в обслуживании нефтепроводов. Фокус статьи включает в себя роботизированные системы, дистанционное мониторинг, технологии превентивного обслуживания и использование нанотехнологий и материалов будущего. Рассмотрены преимущества, применение и перспективы развития каждой из этих инноваций, а также их вклад в повышение безопасности, эффективности и устойчивости нефтегазовой инфраструктуры.
Модифицированный битум с кубовыми остатками при производстве анилина (асд)
Authors: Нескордеев В.А.
Published: April 2024

Проведено исследование по приготовлению и разработке модифицированного вяжущего на основе использования кубовых остатков (АсД) при производстве анилина, разработана технология изготовления модифицированного битума, а также, рассмотрена возможность использования модифицированного битума для изготовления горячего щебеночного асфальтобетона типа Б с отходами дробления известняков (ОДИ) из местных месторождений Чувашской Республики путем замены минерального порошка, дробленого песка на ОДИ. Проведены предварительные испытания. Рассмотрены количественные и качественные показатели в лабораторных и производственных условиях к асфальтобетонам типа Б, которые полностью соответствуют требованиям действующего ГОСТ 9128-13 "Смеси асфальтобетонные, полимерасфальтобетонные, асфальтобетон, полимерасфальтобетон для автомобильных дорог и аэродромов". Применение конструкционного материала для покрытия дорожной одежды лесовозных автомобильных дорог и дорог общего назначения, обеспечивает снижение расхода, вяжущего и себестоимости асфальтобетонной смеси путем замены минерального порошка, дробленого песка ОДИ из местных месторождений и применение местной добавки с химического завода.
Workforce and Employment Status of Sleep Medicine Graduates in Iran
Authors: Samadi Shahram , Sadeghniiat Haghighi Khosro , Najafi Arezu , Rahimi-Golkhandan Ania , Moradian Farid , Amirifard Hamed , Alemohammad Zahra Banfesheh , Nikeghbalian Zahra
Published: April 2024

Background and Objective: Sleep medicine is a multidisciplinary specialty that focuses on diagnosing and treating sleep disorders. Sleep medicine fellowship programs in Iran commenced in 2012 at Tehran University of Medical Sciences, Tehran, Iran. This study aimed to investigate the human resources and employment status of sleep medicine fellowship graduates in Iran.
Materials and Methods: This study was a descriptive cross-sectional study conducted in Iran in 2022 using conven- ience sampling and included 41 sleep medicine fellows in Iran. Data collection tools included a demographic question- naire and a researcher-made survey. Data were analyzed using the SPSS software.
Results: Out of 57 sleep medicine fellows, 41 individuals with an average age of 44.95 ± 7.57 years participated in the study. Only 12% of the fellows were satisfied with their income, and all participants expressed dissatisfaction with their insurance coverage. 92% considered the existence of a national guideline for sleep medicine to be crucial, while 66.7% felt the curriculum of medical sleep medicine had some deficiencies.
Conclusion: Lack of a suitable national guideline for treating and preventing sleep disorders, lack of insurance coverage for tests and respiratory assist devices, and high costs of establishing and equipping specialized sleep clinics are major challenges recognized by sleep medicine fellows. Additionally, due to the low priority given to these diseases by authorities and the inappropriate distribution of sleep medicine specialists in the country, access to appropriate treatment for sleep disorders is only feasible in giant cities.
Possible Interaction Between Drugs for COVID19 And Cancer Therapy
Authors: Marfe Gabriella , Kumar Shukla Arvind , Tarro Giulio , Di Stefano Carla
Published: April 2024

At the end of 2019, a new disease was reported in Wuhan China and described such as severe acute respiratory syndrome (SARS). This new virus named SARSCoV-2 S is characterized by high infectivity among humans. Such disease can have no symptoms in some individuals, while in others can provoke flu like symptoms or acute respiratory distress syndrome, pneumonia, and death. At the end of January 2020, the World Health Organization and Public Health Emergency of International Concern declared a pandemic status. Many studies showed a high mortality rate in cancer patient infected by SARS-CoV-2 infection. In this context, the decision of a safe and effective treatment against COVID19 plays a crucial role crucial in these patients Therefore, important questions arose: Can the COVID19 therapies protect everyone and above all cancer patients? and which drug interactions can occur between cancer therapy and COVID19 treatment? In this regard, Covid-19 is a new disease and for this reason it will be necessary to modify constantly pharmacological treatment. In this scenario, the potential drug–drug interactions (DDI) in the cancer patients should be considered to evaluate the risks and benefits of drug combinations.
Does Desmopressin Reduce Intraoperative Bleeding in Patients Who Undergo Nasal Surgery? A Systematic Review and Meta-Analysis
Authors: Kim Sun Hong , Bae Ah Young , Kim Do Hyun , Hwang Se Hwan
Published: April 2024

Background and Objectives: This study aimed to determine the efficacy of prophylactic desmopressin administered via the intranasal or intravenous route in reducing intraoperative bleeding during nasal surgery. We conducted a meta-analysis of the relevant literature to investigate the role of preoperative desmopressin in minimizing bleeding complications associated with nasal surgery.Methods: We screened the relevant literature published before February 2023. Nine articles that compared the perioperative use of desmopressin (treatment) with a placebo or no treatment (control) were included. The analyzed outcomes were intraoperative bleeding during nasal surgery and postoperative morbidity.Results: The treatment group showed significant improvements in intraoperative bleeding, the surgical field, and surgeon satisfaction compared to the control group. However, the prophylactic use of desmopressin was associated with elevated blood pressure and decreased serum sodium levels compared to the control group. Nonetheless, no significant adverse effects were reported in the included studies. Subgroup analyses comparing the route of administration (intravenous vs. intranasal) and type of surgery (rhinoplasty vs. endoscopic sinus surgery) showed that desmopressin had a beneficial effect on intraoperative bleeding and the surgical field, regardless of the route of administration or type of surgery.Conclusion: The prophylactic use of desmopressin for nasal surgery effectively reduced intraoperative bleeding, improved the surgical field, and increased surgeon satisfaction, with no significant adverse effects. However, caution should be exercised when administering desmopressin as it may cause an elevation in postoperative blood pressure in patients with cardiopulmonary problems.
Outbreak of African Swine Fever in Government Pig Farm at Ranchi, Jharkhand
Authors: Sinha Shreya , Singh Shreeniwas , Murmu Sunita , Sahay Swati , Mahtha Bipin Bihari
Published: April 2024

An atypical form of African swine fever was recorded in pigs of Government pig farm at Ranchi Jharkhand. In this outbreak a total of 1240 pigs died within 30 days. Upon laboratory examination the disease was confirmed to be African swine fever.Immediately rest of the pigs were isolated and biosecurity measures were ensured. The present case report deals with the outbreak of African swine fever virus in a Government Pig Farm at Kanke, Ranchi (Jharkhand) with 95.3% mortality in pigs.
Thermal conductivity of urban and artificial soils: methodological aspects and mathematical modeling
Authors: Kokoreva A. A. , Kozhunov A. V. , Butylkina M. A. , Dymova I. V. , Stepanenko V. M. , Ivanova A. E.
Published: April 2024

There are various methods for experimental determination of the thermal conductivity dependence on soil moisture and substrates. The influence of the sample structure (monolith, bulk sample), sample temperature, the method of installing the probe into the sample on the obtained readings of the TEMPOS device was studied and methodological recommendations were proposed. The dependence of thermal conductivity of soils bulk samples and substrates on moisture is shown. The spread of thermal conductivity values in the moisture range from hygroscopic to full moisture capacity for soddy-podzolic soil is 0.229–1.430 W/(m*K), for peat – 0.250–0.521 W/(m*K), for sand – 0.280–2.605 W/(m*K), for a mixture – 0.234–1.568 W/(m*K). ). The influence of properties such as density, particle size distribution, specific surface area, organic matter content, salinity affected thermal properties to a lesser extent. The established patterns can be used to calculate the temperature regime of soils in solving a number of applied problems related to the construction of special soil objects, for example, when creating urban soil structures. For this, it is necessary either to determine the thermal conductivity experimentally, or to calculate it, using the physical parameters of soils and substrates. The first method is labor-consuming, the second is less accurate. As an example, the equations available for work in the HYDRUS-1D (Chang–Horton and Campbell) model are used. These equations either overestimate the thermal conductivity in the area of high substrate humidity, or underestimate the thermal conductivity in the area of low substrate humidity (sand, loam, peat and a mixture based on them).
Ecological and agricultural assessment of the state of forage lands of boreal river floodplains in the oil-producing region (case study in the floodplain of the Kolva River, Usinsky district, Komi Republic)
Authors: Avetov N. A. , Koptelov A. G. , Lozbenev N. I. , Solovyov D. A. , Shishkonakova E. A.
Published: April 2024

Floodplain forage lands of the Pechora basin (Usinsky district of the Komi Republic) are experiencing a complex anthropogenic impact associated with both agricultural activity and pollution with petroleum products coming with flood waters. An ecological and agricultural assessment of the soil-vegetation cover of the Kolva floodplain used as hayfield (right-bank part) and pasture (left-bank part) was carried out. Soil combinations of the main part of the surveyed floodplain include alluvial sod, sod-meadow and meadow soils. Morphological signs of gley formation in meadow soils are observed in the lower part of the soil profile and are expressed moderately. Soils are characterized generally by favorable agrochemical and morphological properties, with the exception of areas subjected to pasture digression. The vegetation cover of the central and near-river part of the floodplain massif of the right bank is mainly represented by legume-cereal-grass communities formed both in inter-ridge depressions and on flat ridges. On the high floodplain of the left bank, legume-cereal-grass meadows, grass-clover and tufted hairgrass meadows are common, horsetail–butterbur, clover-cereal and cereal communities are common in the near-river part of the left bank. Despite the relatively high productivity and the presence of valuable forage species of cereals and legumes, the qualitative characteristics of hay deviate from optimal ones due to the participation of low-nutritious, unattractive, weedy and poisonous species in the herbage. On the pasture, as a result of pasture digression, there is a decrease in species diversity with the dominance of tufted hairgrass and low-value species of various grasses. In the most disturbed areas, the total projective vegetation coverage is reduced to 50%. The soil cover of the studied territory of the Kolva floodplain is currently not contaminated with hydrocarbons, with the exception of a few spots of petroleum products with a total area of 6 m2. The effect of oil pollution on the vegetation cover of the Kolva floodplain is not manifested. Background values of the content of petroleum products in soils are slightly higher in the left-bank part compared to the right-bank part.
Updating of soil map of mountaneous regions of Uzbekistan
Authors: Gafurova L. A. , Savin I. Yu. , Djalilova G. T.
Published: April 2024

: One of the latest updates on the soil cover of the mountain regions of Uzbekistan is contained in the “Atlas of the Soil Cover of the Republic of Uzbekistan”, published in 2010. It contains soil maps of the regions of the country at the scales of 1 : 350 000 to 1 : 2 500 000 and provides brief charateristics of the soils. The Atlas was compiled on the basis of traditional methods of soil mapping. As a result, its contour part is typical of maps of the mentioned scales and rather schematic. The aim of the research was to update the contour part of the soil maps of mountain territories of Uzbekistan, contained in this Atlas, by means of the analysis of Landsat 8 satellite data. The contour part of the map was updated for the territory with absolute terrain altitude exceeding 900 m. Updating of the map contours was based on the methods of interactive indirect interpretation, when the boundaries of the contours were specified in the GIS using as a substrate the color composites of satellite data obtained at the optimal time of survey. Map correction, mountainous area delineation, and area counting were performed using the GIS ILWIS v.3.3 software package. About 18% of all soil mapping units were divided into several subunits. For 37% of the soil mapping units the boundaries changed significantly (the area of the units changed – by more than 30% with an average change in the length of the boundary of 15–38%). For 45% of soil mapping units the boundaries had changed less significantly (the area of the units had changed by no more than 30% and the boundary length had changed by no more than 20%). No cases of merging of soil mapping units were recorded. As a result, the contour part of the corrected map, compared to the original one, became much more detailed with more indented boundaries. The updated map shows the natural soil cover, excluding the anthropogenically changed soils. But the approach used for updating the original soil map may be also applied to expand the information on anthropogenical load as well. Moreover, this information can be obtained by interpretation of the same satellite data that were used for the map updating.
Technical and technological support for the involvement of fallow lands in agriculture
Authors: Mitin S. G. , Sysoev G. V. , Starostin I. A. , Eshchin A. V.
Published: April 2024

Sustainable development of agricultural production is a key factor in ensuring food security and growth of the country's export potential. One of the main reserves for the development of the agro-industrial complex is the involvement of fallow lands in agricultural industry, which is associated with the problem of technical and technological support for these works. The purpose of the work is to intensify the process of involving fallow lands in agriculture by developing a program of technical and technological support for this type of works, aimed at creating and accelerated implementation of a system of specialized machines. The authors systematized technologies and complexes of technical means, used in the involvement of fallow lands in crop production, depending on the stages of wild species overgrowth. For active involvement of fallow lands in agriculture, it is proposed to create a network of regional machine-technological stations equipped with modern domestic specialized equipment, providing services in removal of woody and shrubby vegetation and in initial tillage to agricultural producers in regions. The program assumes the development and organization of mass production of modern equipment for the involvement of fallow lands in agriculture, as well as implementation of a set of support measures aimed at accelerated technical equipment of machine-technological stations. Such an approach should make it possible for small and medium-sized agricultural producers to use financially affordable machinery services to involve fallow lands in agriculture, eliminating the need for its acquisition and maintenance, hiring and training of additional stuff. The implementation of the proposed program should allow agricultural producers to involve fallow lands in agricultural production with minimal costs, at the same time ensuring high growth rates of acreage and agricultural production volumes.
Pyrogenic transformation of the phosphate state of permafrost forest soils of Central and Southern Yakutia
Authors: Zakharova O. G. , Chevychelov A. P.
Published: April 2024

For the first time, the phosphate state of permafrost forest post-pyrogenic polycyclic soils of Central and Southern Yakutia, formed respectively in arid and humid climates, was studied and evaluated. These soils with a polycyclic profile, formed in the transaccumulative facies of this regions of the permafrost zone, contain, in addition to the modern one, 2–3 buried humus horizons with abundant inclusion of black charcoal. These pyrogenic humus horizons are characterized by an increased content of humus, total nitrogen and phosphorus soluble in iron oxalates, exchange bases, as well as fractions of physical clay and silt compared to neighboring mineral horizons of the soil profile. At the same time, the brown soil of Southern Yakutia, formed under less severe and humid climatic conditions, compared with those of the pale soil developed under cryoarid conditions of Central Yakutia, was more biogenic, and the total content of phosphorus here was 98.0–427.2, whereas in the second soil – only 11.0–257.1 mg P2O5/100 g of soil. Organophosphates predominated in the composition of the total phosphorus of burozem, amounting to 51.8–81.3%, and in pale soil – mineral forms of phosphorus, which accounted for 52.2–78.8%. The fractional composition of mineral phosphates of both types of permafrost soils was mainly dominated by phosphates of one and a half oxides (Al-P and Fe-P), totaling 43.3–94.3%, and among the latter – Fe-P, which accounted for 34.8–87.4% of the total amount of all fractions of mineral phosphates. It is assumed that the high content of iron phosphates, and in some cases occluded aluminum-iron phosphates in the studied permafrost soils, is due to the manifestation of both cryogenic and biogenic pyrogenic ferruginization in their genesis.
Contamination and suitability of soils for growing bio products in Russia
Authors: Ivanov A. L. , Stolbovoy V. S. , Grebennikov A. M. , Dukhanin Yu. A.
Published: April 2024

The area of impact zones of industrial contamination, oil and oil products spills, motor vehicle emissions, radioactive substances, as well as pesticides and mineral fertilizers application on agricultural lands of the Russian Federation is calculated. The share of the territory under consideration in the total area of agricultural lands of the country does not exceed 3%. Soils in the zone of contamination influence are considered to be potentially polluted and should be included in the monitoring program of agricultural land. Soils outside the zone of influence of pollutant dissemination are uncontaminated. Regular monitoring of contamination of these soils should not be carried out, which will reduce the costs of monitoring. More than 97% of the Russian agricultural land is represented by uncontaminated soils and is suitable for the production of bio products. Regular monitoring of contamination of these soils should not be conducted, which will reduce the cost of the survey, including sample collection, preparation and analysis. In view of the lack of soil contamination, the transition to the cultivation of bio products should be based on declarative approach. In this case, bio production should meet the requirements of special cultivation technologies and the product quality standards.