bluuebunny/crossref_metadata_2025 huggingface dataset:
Studi Awal: Persentase Penetasan dan Performa Pertumbuhan Benih Ikan Clown (Amphiprion percula)
Authors: Susanti Handrina
Published: June 2020

AbstrakPermintaan ikan clown (Amphiprion percula) saat ini cukup tinggi, baik untuk pemenuhan pasar dalam negeri dan pengiriman ke luar negeri. Perkembangan kondisi pasar yang menggiurkan tersebut, tentu akan memacu para eksportir untuk mengeksploitasi sumber dialam secara tidak terkendali. Tujuan dari studi ini adalah untuk menghitung persentase penetasan dan performa pertumbuhan benih ikan clown. Studi ini dilaksanakan di Balai Perikanan Budidaya Laut (BPBL) Lombok, Nusa Tenggara Barat. Studi ini menggunakan metode observasi secara langsung pada wadah pembenihan dan pemeliharaan larva ikan clown. Induk ikan clown dipijahkan pada akuarium ukuran 0,4 m × 0,3 m × 0,5 m. Jumlah telur yang dihasilkan bervariasi sekitar 403-698 butir/induk dengan persentase fertilisasi dan penetasan, masing-masing sebesar 97,29 dan 82,87 %.. Selanjutnya larva dan benih ikan dipelihara di bak beton dengan ukuran 2 m × 2 m × 1 m. Persentase kelangsungan hidup benih mencapai 98,33 % dan peningkatan bobot tubuh rerata setiap minggu adalah 0,332 , 0,343, 0,388, dan 0,421 g. Budidaya ikan clown di darat dengan kelangsungan hidup tinggi dapat mengurangi tingkat eksploitasi ikan clown di alam dan kebutuhan akan ekspor ikan hias dapat terpenuhi.Kata kunci- Amphiprion percula, pembenihan, pembesaran benih, hatching rate, survival rate
A formação o complexo regional de segurança energética pela Energiewende na União Europeia
Authors: De Souza Matilde , Gomes Ferreira Leandro
Published: June 2020

No artigo discute-se como Energiewende converge a UE para um complexo de segurança energética. Baseia-se na teoria do Complexo Regional de Segurança, considerando a energia como um setor de análise que lida com o trade-off segurança energética e mudanças climáticas. Verifica-se que a UE evita medidas extremas sobre energia, encorajando a Alemanha a apresentar uma política regional partindo de experiências domésticas, o que a torna o principal exportador de energias renováveis.
Destinations of Male Outmigration and their Drivers in Indian Sundarbans
Authors: Saha Shatabdi , Goswami Rupak
Published: June 2020

Economic liberalisation has created opportunities for semi-skilled labours within and outside India. This study investigates the male out-migration from the Sundarbans region of India with special reference to the choice of their destinations. Following a mixed-method approach, we collected data through a questionnaire survey, in-depth interviews, focus group discussions, key-informant interviews, and Participatory Rural Appraisal. Analyses revealed that migrants tended to travel to diverse inland and even to overseas destinations on a fixed condition, facilitated by pre-existing support networks. The decision on choosing a destination is regulated by several micro-level determinants such as migration chronology, education, and acquired skill, life cycle stage of the migrants, the expected amount of remittance, the reason for migration, and nature of the job at the destination. The destinations abroad are often preceded by migration to inland destinations leading to higher acquired skill and savings. Joint families, having the ability to support international travel and access to support networks, were more prone to reach international destinations.
Interpreting Culture, Society and Space: Folk Music Perspective
Authors: Singh Ravi
Published: June 2020

Cultural Geography per se is one of the marginal sub-disciplines of Geography in India and contributed mainly by practitioners from other disciplines like Anthropology, Sociology, Cultural Studies, Architecture, etc. Due to this reason, the sub-fields of Cultural Geography did not grow in this land of rich cultural heritage and traditions. One such field is the Geography of Music. The objective of this brief editorial note is to demonstrate the potential of folk music as a source of knowing the changing trends and patterns in society, culture, and economy and their spatiality. The examples cited are mainly from the Middle Ganga Valley, a region in which Bhojpuri is the language of the common populace, in which the author is currently based.
Ketersediaan Lahan Mendukung Ekspor Jagung Kabupaten Bengkayang ke Malaysia
Authors: Masganti Masganti , Susilawati Ani , Yasin Muhammad
Published: June 2020

Abstrak. Jagung merupakan tanaman multifungsi, tetapi di Indonesia lebih banyak dimanfaatkan untuk bahan pakan ternak. Kelangkaan komoditas ini di pasaran berefek ganda terhadap industri pakan, harga pakan dan harga ayam potong dan telur. Kebijakan Pemerintah melarang impor jagung dan mengekspor 3,0 juta ton jagung ke Malaysia perlu didukung secara penuh dan konsisten. Kabupaten Bengkayang merupakan sentra produksi jagung Kalimantan Barat dengan kontribusi 76,71%. Petani di kabupaten ini sudah terbiasa membudidayakan jagung dengan rata-rata produktivitas 4,07 t ha-1. Dari 17 kecamatan yang ada, semuanya mempunyai tradisi menghasilkan jagung. Peningkatan produksi jagung melalui perluasan areal tanam dengan memanfaatkan sekitar 183.934,5 ha lahan yang merupakan (1) perluasan areal tanam melalui pemanfaatan lahan kehutanan APL dan HP, (2) tumpangsari dengan tanaman perkebunan, (3) optimasi lahan bera, dan (4) intensifikasi daerah sentra produksi. Dengan memanfaatkan lahan tersebut, Kabupaten Bengkayang berpotensi menghasilkan 665.434 ton jagung pipilan kering atau setara dengan 21,85% quota ekspor jagung ke Malaysia. Perluasan areal tanam jagung di Kabupaten Bengkayang perlu didukung oleh hal-hal teknis seperti (a) ketersediaan tenaga kerja yang terampil, Alsintan (pengolah tanah, pemeliharaan, pemanen, dan pemipil, dryer), lantai jemur, air, saprodi (benih, insektisida, herbisida), dan pupuk organik, (b) pendampingan teknologi dari penyuluh dan peneliti, dan (c) kelembagaan seperti kios saprodi dan organisasi petani.
Pengembangan Pertanian Lahan Kering Iklim Kering Melalui Implementasi Panca Kelola Lahan
Authors: Heryani Nani , Rejekiningrum Popi
Published: June 2020

Abstrak. Wilayah lahan kering beriklim kering pada umumnya memiliki curah hujan rendah kurang dari 2000 mm/tahun. Keterbatasan air dan kesuburan tanah yang rendah menjadi kendala dalam pengembangan lahan jenis ini. Selain itu kondisi lahan pada umumnya berbukit dan bergunung dengan solum tanah dangkal dan berbatu. Salah satu upaya peningkatan produktivitas lahan ini adalah melalui aplikasi panca kelola lahan kering iklim kering guna mendukung swasembada pangan, meliputi: pengelolaan air; pemupukan berimbang; pengelolaan bahan organik, ameliorasi dan konservasi tanah; integrasi tanaman ternak; dan penguatan kelembagaan tani. Produktivitas lahan dan indeks pertanaman yang rendah di lahan kering iklim kering memungkinkan untuk ditingkatkan melalui pemberian irigasi suplemen. Sumber irigasi suplemen dapat berasal dari bangunan panen air berupa embung, dam parit, long storage, pemanfaatan air sungai, air tanah dangkal dan dalam. Aplikasi irigasi hemat air bagi tanaman sangat diperlukan pada kondisi air terbatas. Pemupukan berimbang dengan teknologi nano; pengelolaan hara terpadu yang mengkombinasikan pupuk anorganik dengan pupuk organik dan pupuk hayati; pemanfaatan limbah tanaman untuk pakan ternak dan sebaliknya kotoran ternak untuk bahan organik bagi tanaman; serta pendampingan dan pembinaan kelembagaan secara intensif perlu dilakukan untuk keberlanjutan pertanian lahan kering iklim kering.

 

Abstract. Dryland with dry climate areas generally characterized by low rainfall of less than 2000 mm/year. Water limitations and low soil fertility become obstacles in the development of this type of land. In addition, land conditions are generally have a hilly and mountainous area, shallow solum and rocky soil. One of the efforts to increase land productivity is through the application of five land management of dry land with dry climate area to support food self-sufficiency, such as: water management; balanced fertilization; organic matter management, amelioration and soil conservation; livestock crop integration; and strengthening farmer institutions. Low land productivity and cropping index in dry land with dry climate area makes it possible to increase through the aplication of supplementary irrigation. Sources of supplement irrigation were come from water harvesting infrastructures such as water reservoir, channel reservoir, long storage, river water utilization, shallow and deep ground water. Water saving irrigation are very necessary in limited water conditions. Balanced fertilization with nano technology; integrated nutrient management that combines inorganic fertilizers with organic fertilizers and biological fertilizers; utilization of crop waste for animal feed and vice versa livestock manure for organic material for plants; and intensive institutional assistance and guidance, needs to be carried out for the sustainability of dry land with dry climate agriculture.
Pengelolaan Tanah dan Air Pada Budidaya Padi Gogo dan Palawija di Bawah Tegakan Tanaman Tahunan untuk Meningkatkan Produktivitas Lahan
Authors: Heryani Nani , Kartiwa Budi , Hamdani Adang , Sutrisno Nono
Published: June 2020

Abstrak. Pengembangan padi gogo di lahan kering yang ditunjang oleh teknik pengelolaan tanah dan air yang tepat, berpeluang sebagai salah satu alternatif penyediaan pangan masa depan dan mampu mendukung peningkatan ketahanan pangan nasional. Perluasan areal tanam untuk tanaman padi gogo di lahan kering di bawah tegakan merupakan salah satu strategi dalam menyokong peningkatan produksi padi sawah. Inovasi teknologi pertanian untuk pengembangan padi gogo pada lahan kering di bawah tegakan tanaman tahunan perlu dilaksanakan secara terpadu meliputi: 1) penggunaan varietas toleran naungan, 2) pengembangan teknik konservasi tanah seperti pembuatan teras, guludan, rorak; penggunaan mulsa dan penanaman rumput, 3) pengembangan sistem  integrasi tanaman-ternak, 4) pemanfaatan teknologi panen air melalui embung, dam parit, long storage, dan pemanfaatan air sungai. Pengelolaan air pada pengembangan padi gogo dan palawija di bawah tegakan tanaman tahunan terutama pada musim kemarau merupakan hal yang mutlak dilakukan. Sumber air irigasi dapat berasal dari infrastruktur panen air atau sumber air lainnya.

Abstract. The development of upland rice in dry land, which is supported by appropriate soil and water management techniques, has the opportunity as an alternative in future food procurement efforts. It could also support the improvement of national food security. Expansion of the planting area for upland rice in dry land under crops is one of the strategies to support the increasing rice production. Innovations of agricultural technology for the development of upland rice on dry land under estate crops or forestry should  be implemented in an integrated manner, including: 1) the use of shade tolerant varieties, 2) the development of soil conservation techniques such as terraces, mulch and grass planting, 3) development of crop-livestock integration systems, and 4) utilization of water harvesting technology through small reservoir, channel reservoir, long storage, and river utilization. Water management is absolutely necessary in the development of upland rice and secondary crops under annual crops.  The alternatives  water resources for irrigation are water harvesting infrastructure and other water sources.
Tests of Impregnation Speed of Electrotechnical Pressboard with Insulating Oil
Authors: Kozak C.
Published: June 2020

The paper presents a new test stand for ivestigating the rate of penetration of transformer oil through electrotechnical pressboard. The stand consists of a pipe, to the lower end of which is glued a pressboard plate. The pipe is filled with insulating oil. A mirror is placed under the plate, which directs its image to the lens of the camera, which takes a series of photographs at a given time interval. After being saturated with the insulating oil, the pressboard changes colour from light to dark yellow. The absorbing time is defined as the time in which a dark yellow spot appears on the lower light surface of the pressboard after the pipe is filled with oil.

A new way of determining capillary diameters has been developed when the number of capillaries is unknown and the volume of liquid flowing through them is not measurable. The distribution of the times of penetration of transformer oil through 2 mm thick electrotechnical pressboard was determined, the values of which range from about 220 min to about 550 min. It was found that the radii of capillaries through which the insulating oil penetrates are within the range from about 45 nm to about 70 nm. Due to the structure of the pressboard, which consists of cellulose fibres, arranged more or less tightly, there are capillaries in the structure of the board, each of which has sections of varying lengths of radii. This means that short sections of a single capillary can have radii both smaller than 45 nm and larger than 70 nm.

The developed stand and the new analysis method can be used for testing various porous materials for penetration by various liquids.
H.Pylori Infection Induces CXCL8 Expression and Promotes Gastric Cancer Progress Through Downregulating KLF4
Authors: liu zhengxia , Wu Xiao , Tian Yuanyuan , zhang wanchun , qiao siyuan , xu wenting , liu yakun , Wang Siying
Published: June 2020

The authors have withdrawn this preprint due to erroneous posting.
Lower expression of the RASSF10 gene induces myeloma cell proliferation due to hypermethylation of the gene promoter in multiple myeloma
Authors: Chen Jin , Liu Hui , Liu Zhaoyun , Shao Qing , Jiang Fengjuan , Yan Siyang , Li Lijuan , Song Jia , Ding Kai , Fu Rong
Published: June 2020

Background: Multiple myeloma (MM) is an incurable malignant neoplasm of plasma cells, in which genetic defects, epigenetic aberrations and bone marrow microenvironment are involved in the pathogenesis. RASSF10 acts as a tumor suppressor gene by methylation in glioma and several other cancers, but its role in MM remains unknown. Methods: In order to explore the role of RASSF10, mRNA expression was detected in MM patients and analyzed with overall survival. Results: Expression of the RASSF10 gene significantly decreased in newly diagnosed MM patients, and was positively correlated with overall survival. RPMI-8226 and OPM-2 cell lines with lower RASSF10 expression were selected for further study. Overexpression of RASSF10 in these two cell lines inhibited proliferation and induced apoptosis. The RASSF10 gene promoter in MM cell lines was hypermethylated, and downregulated after decitabine treatment. Meanwhile, expression of the RASSF10 gene was upregulated. MM cells with overexpression of RASSF10 were injected into nude mice and exerted anti-MM activity in vivo. Conclusions: Low expression of RASSF10 contributed to the proliferation of myeloma cells by hypermethylation of its promoter.
Co-loading of Levodopa and Curcumin Using Brain-targeted Protocells as a Drug Delivery System for Improving the Efficacy of Parkinson's Disease
Authors: zhou wenkai , Liu Chang , Yu Feifei , Niu Xia , Wang Xiaomei , Li Guiling , Li Xinru
Published: June 2020

Parkinson's disease (PD), one of the most common movement and neurodegenerative disorders, is challenging to treat, partly because the blood-brain barrier blocks passage of most drugs. Levodopa is a common clinical drug for controlling the symptoms of PD, but it only replenishes the missing dopamine, can’t protect dopaminergic neurons. While curcumin as a neuroprotective agent has been reported for treatment of PD. Herein, we present a novel organic-inorganic composite nanoparticle with brain targeting (denoted as lf-protocells) for co-delivery of levodopa and curcumin, and demonstrate its attractive use as a biocompatible platform for PD treatment. The nanoparticle system is comprised of a lactoferrin (lf) modified lipid bilayer (LB) containing curcumin as its outer membrane and mesoporous silica nanoparticles (MSNs) containing levodopa as its supporting inner core. Our studies illustrate that the lf-protocells have a size of about 180 nm and spherical morphology, and can be used to co-load levodopa and curcumin efficiently. Further, a cell model and a mouse model induced by rotenone (Rot) and MPTP respectively are used to investigate the effects of binary-drug loaded lf-protocells on PD. Our results demonstrate that the combination of curcumin and levodopa alleviate the apoptosis of PD cells, enhance the cell viability as compared to levodopa used alone; levodopa together with curcumin also efficiently decrease the expression of a-synuclein, increase the expression of tyrosine hydroxylase in SH-SY5Y cells, and transform more levodopa into dopamine for supplement the loss of the brain. Moreover, the resulting binary-drug loaded lf-protocells ameliorate oxidative stress and mitochondrial dysfunction as compared to combination of free drugs. In addition, testing in a mouse model indicate that lf-protocells can improve significantly the motor function and distribution in brain compared with unmodified protocells. In conclusion, binary-drug loaded lf-protocells show much better therapeutic efficacy in both the cell model and the mouse model of PD than single free drug and lower toxicity than bare MSNs. These results suggest that lf-protocells can be used as a promising drug delivery platform for targeted therapy against PD and other diseases of the central nervous system.
Optimization The Effect of Roasting Conditions by Central Composite Design (CCD) Method on The Antioxidant Compounds of Opuntia Ficus Indica Seeds From Morocco
Authors: Guezzane Chakir El , Moudden Hamza El , Harhar Hicham , Zarrouk Abdelkader , Tabyaoui Mohamed
Published: June 2020

The effect of roasting conditions on antioxidant activity Opuntia Ficus Indica seeds from Morocco and their phenolic compounds were optimized by the Central Composite Design (CDD) method. The CCD was used to optimize the roasting conditions: temperature (X1: 60–200 °C) and roasting time (X2: 10–50 min). The best roasting conditions were used in order to optimize the optimal value of the response : TPC (Total Phenolic Content): X1: 200°C, X2: 50min with 104.86±1.94GAE/g extract predicted response, TFC (Total Flavonoids Content) : X1: 200 °C, X2: 50 min with 81.23±0.90 mg QE/g extract predicted responses, TTC (Total Condensed Tannins Content): X1: 128.9°C, X2: 34.92min with 6.12±0.95 mg QAE/g extract) predicted response. Moreover, the optimal potential antioxidant activity by ABTS assay and DPPH assay was found in extracts of Opuntia Ficus Indica seeds roasted: at a high temperature of the roasting. Furthermore, the positive significant correlations were determined by the principal component analysis (PCA) on the one hand, between the antioxidant capacity of the extracts and their antioxidants compounds (TPC and TFC), and on the other hand, between the two assays ABTS and DPPH. Consequently, the results of this work indicated that roasted Opuntia Ficus Indica seeds from Morocco can be considered as an essential ingredient for human foods.
The Effect of Endo-1,4-β-Xylanase From Thermomyces Dupontii KKU−CLD−E2−3 on Eucalyptus Pulp Bleaching and Effluent Treatment
Authors: Seemakram Wasan , Harada Hiroyuki , Ekprasert Jindarat , Boonlue Sophon
Published: June 2020

Endo-1,4-β-xylanase-chlorine dioxide bleaching of eucalyptus pulp and analysis of effluent was investigated. The eucalyptus pulp bleaching in D0 stage was prepared with enzyme dose 100 Unit of 10% consistency and incubated at 70 °C for 30 min. The brightness level was achieved up to 72.50 (% ISO). The kappa number and viscosity of eucalyptus pulp was found to be 1.70 and 8.90 (cp), respectively. The paper from pulp bleaching with enzyme has shown an increase in brightness, breaking length, bursting strength, and tearing resistance to be 89.60% IOS, 37.27 Nm/g, 138.81 kPa and 218.02 mN, respectively. The SEM and FTIR analysis of pulp fibers revealed a significance of morphological and structural changes. The analysis of the effluent also showed statistically-significant differences in TOC, BOD, TDS and TSS. The FTIR analysis of the effluent showed the organic compounds and chloride dioxin in cases of those treated by chemicals.
Elevation of serum alpha-1-acid glycoprotein in children with bronchial pneumonia caused by Mycoplasma pneumoniae infection
Authors: Fang Huanying , Zhou Aiping , yang shusheng
Published: June 2020

Background:Alpha-1-acid glycoprotein(AGP) is an acute phase protein which can be elevated under inflammatory conditions. Few studies have explored the use of monitoring serum AGP in Mycoplasma pneumoniae pneumonia(MPP). Methods:We aimed to evaluate the relationship between serum AGP and other convention inflammation bio-markers,in order to explore its clinical significance in children with MPP. Pediatric inpatients with bronchopneumonia from January to December 2018 were enrolled and divided into two groups -children with MPP and children without MPP severed as controls. Serum AGP, procalcitonin (PCT) ,and other laboratory examinations were compared and multiple logistic regressions analysis was used to select the main related factors, then receiver-operating characteristic curves were used to evaluate the value of the selected markers used to identify MPP from bronchopneumonia. Results: Two hundred and sixty-eight children were enrolled in this study.Among them, 87 (32.46%) cases were diagnosed as MPP and 181 gender-matched children were without MPP. Children with MPP were slightly older than those without MPP and had lower levels of serum PCT (P<0.05). In addition, serum AGP was significantly higher in patients with MPP than control participants (136.06±46.37 vs. 122.29±44.21,respectively;P=0.020). Multiple logistic regressions analysis adjusted for age showed that only AGP was the main related factor ,which could perhaps be used to identify MPP from common bronchopneumonia and its area under the curve (AUC) was 0.703(95% CI: 0.634-0.772;P=0.000).Combination with AGP and PCT could slightly improve the AUC(95 % CI) to 0.732 (95% CI: 0.666-0.797, P=0.000). Conclusion: AGP is perhaps a potential bio-marker to distinguish MPP from other bronchopneumonia in children and assist early diagnosis and treatment as soon as possible for it is relatively convenient and fast to be carried out.
INT-777 Improves Cognitive Impairment after Sepsis by Attenuating Neuroinflammation Through the TGR5/cAMP/PKA/CREB Signaling Axis in Rats
Authors: Jin Peng , Deng Shuixiang , Tian Mi , Wei Pengju , Wang Yao , Tan Jiaying , Wen Huimei , Zhao Feng , Gao Yanqin , GONG YE
Published: June 2020

Background: Sepsis survivors are left with significant cognitive and behavioral impairments after discharge, but research on the relevant mechanisms and interventions remains lacking. TGR5 plays a neuroprotective role in many neurologic disease models through different mechanisms. To date, no studies have assessed the effects of TGR5 on neuroinflammation or cognitive or behavioral changes in sepsis models.Methods: A total of 267 eight-week-old male Sprague-Dawley rats were used in this study. Sepsis was induced by cecal ligation and puncture (CLP). All animals received volume resuscitation. The rats were given TGR5 CRISPR oligonucleotide intracerebroventricularly 48 hours before CLP surgery. INT-777 was administered intranasally 1 hour after CLP, and the cAMP inhibitor SQ22536 was administered intracerebroventricularly 1 hour after CLP. Survival rate, bodyweight change, clinical score, neurobehavioral tests, western blot, and immunofluorescence staining were performed. The cognitive function of rats was measured by Morris water maze during 15-20 days after CLP.Results: The expression of TGR5 in the rat hippocampus was upregulated and peaked at 3 days after CLP. The survival rate of rats after CLP was less than 50%, and the growth rate in terms of weight was significantly decreased, while these changes were not improved by INT-777 treatment. However, INT-777 treatment reduced the clinical scores of rats at 24 hours after CLP. On day 15 and later, the surviving mice completed a series of behavioral tests. CLP rats showed spatial and memory deficits and anxiety-like behaviors, and INT-777 treatment significantly improved these effects. Mechanistically, immunofluorescence analysis showed that INT-777 treatment reduced the number of microglia in the hippocampus, neutrophil infiltration and the expression of inflammatory factors after CLP in rats. Moreover, INT-777 treatment significantly increased the expression of TGR5, cAMP, p-PKA, and p-CREB and downregulated the expression of IL-1β, IL-6 and TNF-α. CRISPR-mediated TGR5 knockdown and SQ22536 treatment abolished the neuroprotective effects of TGR5 activation after CLP.Conclusion: This study demonstrates that INT-777 treatment reduced neuroinflammation and microglial cell activation, and then improved cognitive impairment in the experimental sepsis rats. TGR5 has translational potential as a therapeutic target to improve neurological outcomes in sepsis survivors.
Analysis of Changes in Seismicity Pattern for Probabilistic Seismic Hazard Analysis (PSHA) and Mitigation: Mapping Probability Difference before the Large Earthquake and Its Implementation in PSHA & Mitigation around Northern Sumatra
Authors: Triyoso Wahyu , Yudistira Tedi , Sahara David P.
Published: June 2020

The probability difference before the occurrence of a large earthquake is mapped in the northern part of Sumatra, taking the range of Region Time Length (RTL) before a major earthquake (December 26, 2004) around 15 years. By normalizing the absolute value of probability difference between two periods of RTL and before RTL, the Seismic Quiescence Index (SQI) is then defined. Probability difference analysis is done by dividing observations of shallow earthquake periods into two periods based on the similarity gradient of the annual earthquake production, namely 1963-1990 and 1991-November 2004. The results showed that areas with relatively high SQI were consistent with the presence of major earthquake events after November 2004 to 2016 that are sorted by a radius of 300 km with the center point being the epicenter position of the December 2004 earthquake. The implementation of the SQI was then used for probabilistic seismic hazards study and analysis based on an integratedmodel that is derived based on the estimated of seismicity rate of around the subduction zone and active fault of Sumatra Fault Zone (SFZ) sources. The map of Probabilistic Seismic Hazard Analysis (PSHA) is then constructed based onPeak Ground Acceleration (PGA) estimated for a 10% Probability Exceedance (PE) level in 50 years. The results of this study may be very useful for earthquake mitigation and modeling efforts for PSHA going forward.
Landscape of Granulocyte Telomere Shortening in Cytopenia in India
Authors: MANDAL PARAMITA , Dutta Shyamali
Published: June 2020

Objectives: Telomere length and telomerase activity have been implicated in the control of cell proliferation and genomic stability. We recently introduced a novel technique for measurement of the average telomere length in cells using fluorescence in situ hybridization (FISH) with peptide nucleic acid (PNA) probes and flow cytometry (flow-FISH). Results: Using this technique, we have analyzed the telomere length kinetics in subpopulations of unseparated peripheral blood leukocytes (PBLs) in a large population of healthy donors as well as patients with cytopenia. We only found significantly shortened telomeres from patient with cytopenia compared to age-adjusted controls. Strikingly, the telomere length in granulocytes from cytopenia patients differed significantly from controls. Furthermore, an inverse correlation between of granulocyte telomere length and age was found among healthy controls. However, surprisingly, telomere length in cytopenia patients with hypocellular marrow was significantly shorter from patients with non-hypocellular marrow. These results support the concept of accelerated granulocyte telomere shortening in cytopenia patients in India and suggest a potential use of telomere-length measurements as a prognostic tool in this group of disorders as well.
Shifted Phase of EEG Cross-Frequency Coupling in Individuals with Phelan-McDermid Syndrome
Authors: Mariscal Michael G , Berry-Kravis Elizabeth , Buxbaum Joseph D , Ethridge Lauren E , Filip-Dhima Rajna , Foss-Feig Jennifer H , Kolevzon Alexander , Modi Meera E , Mosconi Matthew W , Nelson Charles A , Powell Craig M , Siper Paige M , Soorya Latha , Thaliath Andrew , Thurm Audrey , Zhang Bo , Sahin Mustafa , Levin April R
Published: June 2020

Background Phelan-McDermid Syndrome (PMS) is a rare condition caused by deletion or mutation of the SHANK3 gene. Individuals with PMS frequently present with intellectual disability, symptoms of autism spectrum disorder (ASD), and other neurodevelopmental challenges. Electroencephalography (EEG) can provide a window into network-level function in PMS. Methods Here, we analyze EEG data collected across multiple sites in individuals with PMS (n = 26) and typically developing individuals (n = 15). We quantify oscillatory power, phase-amplitude coupling strength, and phase bias, a measure of the phase of cross frequency coupling thought to reflect the balance of feedforward and feedback activity. Results We find individuals with PMS display increased phase bias (U = 3.841, p < 0.0005), predominantly over posterior electrodes. Most individuals with PMS demonstrate positive overall phase bias while most typically developing individuals demonstrate negative overall phase bias. Among individuals with PMS, strength of phase-amplitude coupling was associated with Sameness, Ritualistic, and Compulsive behaviors as measured by the Repetitive Behavior Scales-Revised (Beta= 0.545, p= 0.011). Conclusions Increased phase bias suggests potential circuit-level mechanisms underlying phenotype in PMS, offering opportunities for back-translation of findings into animal models and targeting in clinical trials.
Effects of regulatory exercise on lipolysis pathway in obese pre and postmenopausal women
Authors: Park Kyu-Min , Lim Seung-Taek , Sung Kun-Young , Kang Sunghwun
Published: June 2020

Background and objectives: The purpose of study was to examine the effects of regulatory resistance exercise for 12 weeks on lipolysis pathway in pre- and post- menopausal women with obesity. Methods: Twenty-three pre- and post- menopausal women with body fat percentages of 30% or more divided into pre- menopausal group (n=9) and post- menopausal group (n=14). All subjects participated in resistance exercise training for 12 weeks. All participant’s anthropometric measurements and physical fitness tests were performed. Protein analyses were performed with subcutaneous fatty tissue extracted, and the samples were analyzed of relevant protein expression changes by using Western blotting. All serum samples were submitted for enzyme-linked immunosorbent assay measurements of adipocyte factors. Results: After 12 weeks between pre- menopausal and post- menopausal groups ATGL, MGL and PLIN protein expression were significantly lower in the post- menopausal group than in the pre- menopausal group. HSL protein expression were significantly higher in the post- menopausal group than in the pre- menopausal group. In addition, leptin concentration was significantly decreased, and adiponectin concentration was significantly increased after resistance exercise in the post- menopausal group more than pre- menopausal group. Conclusions: In this study indicates that regular resistance exercise to change of leptin and adiponectin might be release of overall decreased ATGL, HSL, MGL and PLIN expression in subcutaneous fatty tissue, and driving reduction of % fat in the obese post- menopausal group more than obese pre- menopausal group.
The consistent use of recombinant and plasma coagulation factors in the intensive care of massive obstetric hemorrhage
Authors: Kuligin A. V. , Lushnikov A. V. , Zeulina E. E.
Published: June 2020

Massive obstetric hemorrhage is one of the most threatening complications of pregnancy, delivery and early postpartum period, which are part of the triad of leading causes of maternal mortality both in the world and in the Russian Federation. In recent years, to stop coagulopathy, which is one of the clinical manifestations of massive obstetric hemorrhage, recombinant and plasma factors of the blood coagulation system are successfully used, which include a concentrate of prothrombin complex and activated coagulation factor VII (eptacog alfa activated). The authors present results of successful consistent use of the blood coagulation system factors within comprehensive intensive care of coagulopathy in a patient with massive obstetric hemorrhage.
Combined anesthesia for off-pump coronary artery bypass grafting in patients with visceral obesity
Authors: Turovets M. I. , Shlakhter S. M. , Streltsova A. M.
Published: June 2020

The objective:to analyze results of the use of combined anesthesia for coronary artery bypass grafting without cardiopulmonary bypass (off-pump CABG) in patients with visceral obesity (VO).Subjects and methods.A randomized study of results of surgical treatment in patients with VO and coronary heart disease who underwent off-pump CABG was conducted. 197 patients were included in the study. The main group (n= 98) included patients who underwent combined anesthesia (with thoracic epidural analgesia (TEA)) and patients in the control group (n= 99) underwent total intravenous anesthesia (with narcotic analgesics).Results.In patients from the main group, a significant decrease in the incidence of acute kidney injury (p= 0.0180), respiratory complications (p= 0.0177), atrial and ventricular arrhythmias (p= 0.0029) was recorded. With the use of TEA, the duration of treatment of patients in the intensive care unit (p= 0.0229) and duration of hospital stay (p= 0.0419) significantly decreased.Conclusion:The use of combined anesthesia (with TEA) for off-pump CABG in patients with visceral obesity reduces the risk of early postoperative complications, the duration of hospital stay and treatment in the intensive care unit.
Changes in energy expenditures while reducing pressure support as a predictor of successful spontaneous breathing trial
Authors: Savchenko Ya. V. , Goryachev A. S. , Savin I. A. , Krylov K. Yu. , Polupan A. A. , Birg T. M.
Published: June 2020

The objective: to assess changes in energy expenditures (EE) when reducing pressure support (PS) as a predictor of the patient’s readiness for transfer to spontaneous breathing. Subjects and methods. The study included 33 patients who had been on mechanical ventilation for at least 7 days. PS reduced from 20 to 4 cmH2O at the interval of 4 cmH2O. At each level, the patient's EE were measured with indirect calorimetry. At the end of the study, spontaneous breathing trial (SBT) was performed. Results. In 22 (67%) patients, at least one episode of a statistically significant increase in EE was observed upon transition to a lower level of PS (Group 1). In remaining 11 (33%) patients, with decreased level of PS, EE decreased or did not significantly change (Group 2). SBT was successful in 14 out of 22 patients from Group 1 and all 11 patients from Group 2. The absence of episodes of increased EE during decreased PS was a predictor of successful SBT (sensitivity – 44%, specificity – 100%). Conclusion. The absence of episodes of a statistically significant increase in EE during the transition to a lower level of PS is a highly specific predictor of successful SBT.
The relationship between CEO compensation and financial performance in Jordanian public shareholding industrial companies
Authors: H. Bani Khaled Marie
Published: June 2020

This study aimed to examine the relationship between the compensation received by chief executive officers (CEOs) and the financial performance of Jordanian public shareholding industrial companies listed on the Amman Stock Exchange (ASE) from 2010 to 2017. To measure the variables of interest, secondary data published on the ASE website were processed to become preliminary data suitable for the study. The study population consisted of 56 companies, 25 of which met the inclusion criteria. The results of the analysis of the data on these 25 companies revealed a large difference between the amount of financial compensation received by CEOs and the earnings per share (EPS) received by shareholders. The results also showed a statistically positive and significant relationship between the amount of CEO compensation and the financial performance of industrial companies. Furthermore, return on assets (ROA), EPS, and leverage have a statistically negative and significant relationship with financial performance. However, the net profit margin has a statistically positive and significant relationship with financial performance. Besides, the results showed a positive and significant relationship between the age of the CEO and the amount of compensation received. On the other hand, Tobin’s Q model demonstrated that the relationship between CEO duality and the amount of CEO compensation is not statistically significant. Therefore, the study recommends using more than one type of compensation for the CEOs of public shareholding industrial companies in Jordan and that CEO compensation should be related to financial performance.
New structural seismic protection for high-rise building structures
Authors: Kasimzade Azer A. , Abrar Obaidullah , Atmaca Gencay , Kuruoglu Mehmet
Published: June 2020

Presented Structural Seismic Isolation Method (SSIM) aims to provide high safety for Highly Reliable Structures (HRS) against strong earthquakes including near-fault and long-period ground motions. The examined structure is converted to Structural Seismic Isolation System (SSIS) by the SSIM method which exhibited inverse pendulum behaviour. For this purpose, structure foot base and foundation contact surfaces have been designed as any curved surfaces (spherical, elliptical, etc.) depending on the earthquake-soil-superstructure parameters and this contact surfaces have been separated by elastomeric (lead core rubber or laminated rubber bearings) seismic isolation devices. It would allow the structure foot base to turn around gyration centre through rubber bearing contact and maintains similar behaviour to the super-structure. SSIS system provides the possibility of keeping the natural-period of the structure in a larger interval, which is greater than the predominant-period of the majority of possible earthquakes (including near-fault pulse) using currently existing conventional elastomeric isolators with up to 4 second period. Thus, the structure can sustain its serviceability after strong and long-period earthquakes. In this study SSIS system’s performance is presented for high-rise building structures, for this aim, the finite element model of the building (Bg) structure with SSIS system (SSIS-Bg) has been prepared and the nonlinear dynamic analysis of the model has been conducted using strong and long-period ground motions. Results indicate that the base and top accelerations, base shear and base moment responses of the SSIS-Bg structure is 23.21 %, 75.47 % and 85.74 % in average lower than the Conventional Application Method of Seismic Base Isolation Devices for Building (CAMSBID-Bg) structures respectively and it is not prone to resonant vibrations under long-period earthquakes related with the excessive deformation in the isolation layers in case of using CAMSBID-Bg structures. It should be noted that in this study with the presented SSIM method and SSIS system, it is aimed to protect only the Highly Reliable Structures(HRS) from the effects of strong and long-period ground motions and these structures (HRS) are classified as follows: 1) Nuclear Containment Structures; 2) High-rise buildings that contain information, operating systems, sensitive instruments, communication systems, routing systems, bank operating systems, databases, management systems and other similar facilities that are linked to the security and economy of a country; 3) High-rise hospitals etc.
The influence of the controlling delay time on two-degree-of-freedom system with a high-static-low-dynamic-stiffness isolator
Authors: Zhang Haipeng , Yang Lihua , Su Pan , Liu Shuyong , Zhao Bo
Published: June 2020

In order to research the influence of the control delay time on the vibration isolation system, the dynamic characteristic analysis of a two-degree-of-freedom vibration system, based on high-static-low-dynamic-stiffness vibration isolator (HSLDS-VI) with time-delayed feedback control is presented. The two-degree-of-freedom nonlinear vibration isolation dynamical system model comprising the delay time parameter is also derived. Then, the effects of feedback gain coefficient and delay parameter on the dynamic characteristics are analyzed with multiple scales method. The results demonstrate that the amplitude can be suppressed by the time-delay variation for a fixed feedback gain. The system can exhibit periodic motion or chaotic vibration when the feedback gain coefficient and time-delay parameter are adjusted, which is beneficial to the application of high-static-low-dynamic-stiffness vibration isolator.
Safety evaluations of a large-scale facility under blast loading
Authors: Bai M. X. , Xu X. L. , Yang H. X. , Xiong M. , Zhu W. Q. , Liu Z. P. , Luo C. H.
Published: June 2020

In this work, the safety performance and loading behavior of a large-scale facility were studied using experimental observations, numerical simulations and theoretical calculations. Furthermore, the effects of concentration, pressure relief and volume on the shock wave loadings were investigated. In particular, based on the dimensional theoretical analysis, a model for the analysis of overpressure peak and impulse for such facilities was proposed. The results showed that if concentration was larger than 10.5 %, the peak overpressure and the maximum overpressure rate were decreased; if the ignition mode was chemical, the propagation speed of flame was increased. In addition, it was found that the overpressure was the largest if the concentration was 9.5 %, and with the increase of the distance from the ignition source, the overpressure peak decreased first and then increased. The present study and results can therefore provide the loading information to enhance the antiexplosion performance of such facilities, which is very promising for the future safety evaluations and fault diagnosis of buildings, and constructions in various fields, especially, for nuclear power stations.
Influence of vertical and horizontal whole-body vibration on selected muscles tension of employees age 50+ in relation to professional exposure to vibration (pilot study)
Authors: Kowalski Piotr , Łach Patrycja
Published: June 2020

The pilot study on changes of selected muscles tension caused by vertical and horizontal whole-body vibration focused on employees belonging to two professional (occupational) groups. One of these groups consisted of men aged 50 years professionally exposed to vibration and the second were men not exposed to vibration at the workplace. Tests have been conducted in two series on special designed laboratory test bench for simulation of exposure to whole-body vibration. During the I series of tests, vertical vibration had acted on subjects and during II series horizontal lateral vibration had acted. The EMG signals were registered from muscles of the shoulder girdle and lower back, both sites of the body. Muscles tension values obtained during I and II series indicates that there are no statistical significant differences between reaction of subjects on vertical and horizontal vibration. However slightly lower EMG RMS values during II series were noticed. Exposure to whole-body vibration may cause changes in muscle tension both in employees (aged 50 years and older) occupationally exposed to vibration and not exposed to vibration. The observed changes vary in both groups of subjects. In occupationally exposed to vibration subjects the impact of exposure to vibration on muscle tension is less than in reference group.
An improved spectrum correlation time-frequency analysis method and its application in fault diagnosis of rolling element bearing
Authors: Wang Hongchao , Du Wenliao
Published: June 2020

The spectrum correlation (SC) is an effective fault feature extraction method for rolling bearing which is based on second order cyclic statistic. However, the effectiveness of SC will be compromised greatly when the rolling bearing fault feature signal is interfered by noise. To solve the problem, the SC method is improved and the improved spectrum correlation (ISC) method is proposed in the paper, and the noise-resistance virtue of ISC compared with SC is verified through the accelerated fatigue and compound fault test of rolling element bearing. Besides, the vibration signal of fault rolling bearing takes on modulation phenomenon, and extracting the fault characteristic frequency (FCF) or cyclic modulation frequency (CMF) is enough for the purpose of fault diagnosis, and the modulation frequency is neglected usually. However, the extraction result of ISC is not intuitive enough because it extracts the FCF and modulation frequency with its harmonic synchronously. To improve the intuitive feature extraction effect of ISC, the ISC method is improved further in the paper and the integrated improved spectrum correlation (IISC) is proposed which would only extract the FCF or CMF, so much clear and better extraction effectiveness could be obtained by IISC method, and the effectiveness and better fault extraction results by applying IISC method on vibration data of rolling bearing accelerated fatigue and compound fault test are also presented.
Exact forced torsional vibration solution of a shaft with multiple discontinuities and arbitrary boundary conditions
Authors: Chen Meilong , Li Shuying , Li Hongliang , Liu Siyuan
Published: June 2020

In this paper, the method based on Laplace transform and Fourier transform and their inverse transforms is developed to give an exact solution to the forced torsional vibration of a shaft subjected to multiple inertias, multiple elastic supports, arbitrary boundary conditions and arbitrary excitation forces. Two simple cases are used to show in detail how this developed method can obtain an exact analytical solution to the forced torsional vibration of shaft and the results are compared with Eigenfunction Expansion Method and Finite Element Method (FEM) to demonstrate the accuracy and effectiveness of the developed method. Two more complex cases are investigated to further show the superiority of the developed method over FEM in highly efficient and accurate. Finally, using the developed method, the effects of parameters on forced torsional vibration response of shaft are discussed, including the stiffness, the location of elastic supports and the time interval of impact loading. The developed method can provide a reliable theoretical base not only for analysis and fault diagnosis of a shaft system in engineering signal testing projects but also for the verification of other numerical and analytical methods.
The mathematical model of the improved system of the seat with adjustable pressure profile
Authors: Tran Xuan Tien , Phu Dong Nguyen
Published: June 2020

Following a patented solution, a seat which is possible to change its stiffness was created. The seat contains an actively controlled pneumatic spring element (the PSE). For the requirement of working faster and more precisely, an improvement was applied. This article deals with derivation of mathematical model of the improved PSE system used for subsequent analysis. The model is considered as a mixed model which is a combination of single-discipline subsystems as mechanical, electrical, fluid and control ones. The simulations are carried out for varied input parameters and both the system parameters and system characteristics are calculated. The results describe the behavior of the improved system in two modes of controller setup: constant pressure and constant stiffness under static and dynamic conditions