bluuebunny/crossref_metadata_2025 huggingface dataset:
Adapting Public Spaces to the Wellness Needs of the Local Community
Authors: Švagždienė Biruta , Vaseris Vilius
Published: June 2020

Research problem and relevance. With continuously expanding cities, less space is left for public, open areas. The urban planning is performed with regard to urbanistic elements, however, public spaces do not receive enough attention and creative potential (Piekienė, 2015). Individual’s and state’s political concept of public space changes by virtue of the premise of physical rationality and equality, moral values and the role of nature in modern cities. It is now defined as an urban structure, rather than a physical form of space, which meets not just the physiological needs of the individual, but also the general values of the community. The focus is on the moral, social, cultural details and their combination with physiological needs of an individual. Lately, people have become increasingly concerned about their living or recreational environment, necessity and importance of taking care of their health is no longer in doubt. Therefore, M. Burinskienė (2003) notes the aim to create right conditions that meet the interests of different people in various cities. Thus, in order to create sustainable balance between social, economic and environmental aspects, apart from the development of the physical infrastructure of the city, other aspects should be in focus (Čiegis, Žalevičienė, 2012). Analysis of application of public spaces has revealed that there are many scientific articles about the public spaces and related issues, however, opinions, criticism or discussions on this topic go in the same direction – public spaces are considered as isolated objects, rather than one, closely related system.The aim of the research was to assess the circumstances of adapting public spaces to the wellness needs of the local community on the case of Kaunas. The object of the research was the adaptation of public spaces to the needs of the local community.        Research methodology. The qualitative research was conducted and a semi-structured interview was selected to collect the data using a convenience sampling method: several interviewees were selected from the researchers’ academic environment (university) upon recommendations. The method based on geographical definition was followed when selecting the interviewees. All interviewees study, work and live in Kaunas.Results. The study revealed that the adaptation and accessibility of public spaces for the wellness needs of the local community was still insufficient. Public spaces were not yet directed to even distribution and adaptability and their formation process did not fully satisfy sustainability criteria.Keywords: public space, leisure, community, wellness, adaption.
Gluten related headaches
Authors: Degterev D. A. , Bykova S. V. , Parfenov A. I.
Published: June 2020

Coeliac disease and non-celiac gluten sensitivity are disorders whose diagnosis can be delayed for many years from the first clinical manifestations. Typical debut of coeliac disease is an extraintestinal manifestation as gluten-related disorders. One of such impairments is headache. There are currently data about gluten-associated headache including prevalence, clinical manifestations, diagnostic features and treatment results in this paper.
Comorbidity of irritable bowel syndrome and obesity
Authors: Simanenkov V. I. , Tikhonov S. V. , Dekkanova V. D.
Published: June 2020

The article presents the results of a clinical investigation of 53 patients conducted to identify potential mechanisms of comorbidity of obesity and irritable bowel syndrome. Patients with a combination of these diseases are more likely to experience impaired fasting glycemia, pronounced and emotionally colored complaints on the internal organs, recorded with the Giessen questionnaire of psychosomatic complaints.
Non-drug treatment of non-alcoholic fatty liver disease: evaluation of effectiveness with ultrasound steatometry
Authors: Venidiktova D. Yu. , Borsukov A. V.
Published: June 2020

Objective. Evaluation of the effectiveness of non-drug treatment in patients with non-alcoholic fatty liver disease using the method of quantitative ultrasound steatometry.

Material and methods. We examined 118 patients aged 18–75 years, including 52 (44 %) men and 66 (56 %) women using a single diagnostic algorithm of four stages: questioning and collecting complaints, assessing the quality of life, clinical examination, non-invasive bioimpedansometry, followed by assessment of fat mass index, ultrasound examination of the liver in the B-mode, quantitative ultrasound steatometry by evaluating the attenuation coefficient of the ultrasonic wave. Individual non-drug therapy is prescribed to patients in the form of an individual program of therapeutic nutrition and physical activity. A dynamic assessment of the decrease in the proportion of adipose tissue and the severity of fatty liver infiltration was carried out at points of 6, 12, 18, 24 months. A liver biopsy followed by histological analysis on an SAF scale was performed in 32 patients.

Results. To assess the effectiveness of non-drug treatment in patients, a tendency of reducing the proportion of fat content and the severity of fatty infiltration in the liver was observed. All patients were divided into two groups according to their level of compliance with the prescribed treatment. Decrease in the proportion of adipose tissue in patients with a high level of compliance – up to 76.2 %, in patients with a low level of compliance – up to 89.1 % of the initial values. Decrease in fatty liver infiltration in patients with a high level of compliance – up to 80.2 %, in patients with a low level of compliance – up to 92.1 % of the initial one.

Conclusion. Ultrasound steatometry is an informative method for non-alcoholic fatty liver disease screening. The correlation of quantitative ultrasound diagnostics data for steatosis with a biopsy at stage S0 corresponds to r = 0.85; at stage S1 r = 0.72, at S2 r = 0.73, at stage S3 corresponds to r = 0.84, which indicates the high informativity of this method.
Clinical case of observation of patient with primary systemic amyloidosis
Authors: Fedulaev Yu. N. , Khabazov N. V. , Chuprakova A. Yu. , Ezhikova M. V. , Kurshin A. A. , Limonchikova O. V.
Published: June 2020

Amyloidosis combines diseases that are characterized by extracellular deposition of a specific insoluble fibrillar amyloid protein. The prevalence of amyloidosis is an average of 10 cases per 100 thousand people. The clinic of the disease is polymorphic and depends on the organ with amyloid deposition. The article discusses the clinical case of systemic amyloidosis with damage to the stomach, liver and other organs. The differential diagnosis was carried out with tuberculosis, cancer, cirrhosis. The final diagnosis was made by histological examination of biopsy samples of the liver and stomach. Difficulties in diagnosing primary amyloidosis are due to the attrition and non‑specificity of the clinical picture of the disease. Amyloidosis is diagnosed based on organ biopsy data.
Cytokine regulation of immune status of patients of older age groups with odontogenic phlegmon of maxillofacial region on background of immunocorrective therapy
Authors: Serbin A. S. , Maksutin I. A. , Afanasyeva О. Yu. , Dronov S. V. , Kozenko T. E. , Aleshanov K. A.
Published: June 2020

The influence of the immunomodulator azoximer bromide has been studied on the cytokine regulation of immune status at elderly and senile patients with the odontogenic phlegmon of the maxillofacial region. Clinical and immunological studies of 95 elderly and senile patients with the odontogenic phlegmon of the maxillofacial region were carried out. The authors has been shown including in the scheme of traditional treatment of this disease of azoximer bromide allows to normalize the cytokine regulation of immune status, that enhances the effectiveness of treatment and decreases the term of the patients’ treatment at the hospital.
Reproductive health of women with fat metabolism disorders
Authors: Vedzizheva E. R. , Kuznetsova I. V.
Published: June 2020

Objective: to assess the reproductive health features of women with fat metabolism disorders and the safety of using combined oral contraception in them.

Materials and methods. 150 women of childbearing age (mean age 29.8 ± 4.7 years) were examined, which were divided into three groups depending on the type of impaired fat metabolism: the first group included patients with obesity and dyslipidemia (n = 50); the second group – women with obesity without dyslipidemia (n = 46); the third group – patients with a normal body mass index and dyslipidemia (n = 54). All patients underwent clinical and laboratory examination with the assessment of biochemical, metabolic and hormonal blood parameters. At the second stage of the study, the safety assessment of the use of combined oral contraceptive with chlormadinone acetate (COC–CMA) in women in need of pregnancy protection was performed.

Results. Women with fat metabolism disorders have a high prevalence of menstrual irregularities. The most commonly detected were polycystic ovary syndrome (PCOS), phenotypes A, C, D. In the absence of PCOS in obese women or patients with dyslipidemia at normal weight, the formation of endocrine pathology was observed, associated with hyperandrogenemia or a tendency to hypogonadotropic hypogonadism. Patients with obesity and dyslipidemia had the worst fertility profile and high prevalence of infertility and miscarriage. Taking COC–CMA did not have a significant effect on fat metabolism.

Conclusion. Dyslipidemia and obesity are independent factors in reproductive health problems. Clinical portraits of gynecological endocrine pathology in patients with obesity, dyslipidemia and their combination are different. The assessment of carbohydrate and fat metabolism should be considered one of the important components of the examination of patients with menstrual dysfunction or impaired fertility. COC–CMA can be considered the drug of choice for contraception in women with impaired fat metabolism.
Quality of life and cardiovascular risk in women during menopausal transition and postmenopause
Authors: Kuznetsova I. V. , Voichenko N. A. , Kirillova M. Yu.
Published: June 2020

The task of active longevity is a priority for world and national health care. One of the resources to ensure the quality of life for aging women is the rationalization of nutrition using biologically active additives (BAA), which include substances that have proven effective in stopping the symptoms that accompany the menopausal transition and early postmenopause. Given the association of vasomotor symptoms with an increased risk of cardiovascular disease, it can be assumed that solving the problem of improving the quality of life will positively affect cardiovascular risk. Based on this hypothesis, we set the goal of the study to assess the effect of dietary supplements containing phytoestrogens on the quality of life and markers of cardiovascular risk in women during menopausal transition and postmenopause. An open, controlled study involved women aged 46–58 years who took Estrovel dietary supplement or a vitamin complex without herbal supplements, examined using questionnaires to determine the severity of menopausal complaints, assess mental status, vegetative support, as well as monitor blood pressure, and samples for vegetative providing, analysis of heart rate variability. The results of the study showed that women taking Estrovel dietary supplement to improve the quality of life, in addition to stopping the symptoms of pathological menopause, receive additional benefits in the form of improved psycho-vegetative status and markers of cardiovascular risk with high safety and good tolerance of the method.
Status of microbiota of vaginal tract in women with premature birth (clinical and anamnestic features)
Authors: Abusueva Z. A. , Omarpashaeva M. I. , Khashayeva T. Kh.-M. , Kakvaeva S. Sh.
Published: June 2020

In order to study the characteristics of the obstetric and gynecological history in women with preterm birth and to identify the most significant factors affecting premature termination of pregnancy, 297 cases of preterm birth were analyzed for a period of 22 to 37 weeks of gestation. In the group with preterm birth, statistically significantly more common were women with a history of miscarriage (31.4 %; p = 0.003), with a high parity of childbirth (more than three) (14.8 %; p = 0.0024), with overweight body and obesity of varying severity (37.3 %; p = 0.0012), anemia (58.9 %; p = 0.003), neck diseases with surgical treatment (17.1 %; p = 0.003), nonspecific vaginitis (18.2 %; p = 0.004), bacterial vaginosis (26.3 %; p = 0.002) and abnormalities of the uterus (4.0 %; p = 0.04). Pregnancy was most often complicated by placental insufficiency (63.6 %; p = 0.001), the threat of termination (59.2 %; p = 0.001), amniotic fluid pathology (37 %; p = 0.002) and preeclampsia (22.2 %; p = 0.024). 67 % of patients were noted with preterm birth, dysbiosis of the vaginal tract of varying severity.
Effectiveness of combined drug containing calcium and vitamin D in treatment of primary dysmenorrhea in adolescent girls
Authors: Gevorgyan A. P. , Adamyan L. V. , Arslanyan K. N. , Ivanova G. I.
Published: June 2020

Objective.To increase the effectiveness of early diagnosis and to develop a differentiated approach to the treatment of adolescent girls with primary dysmenorrhea (PD).

Material and methods.The study was conducted on 100 adolescent girls aged 15 to 17 years, diagnosed with primary dysmenorrhea, who were initially divided into study and control groups depending on the presence or absence of dysplasia of connective tissue (DCT). Then, to compare the two proposed treatment regimens, each group was divided by randomization into two subgroups. Basic therapy included drug NSAIDs and vitamin-mineral complex with a content of calcium 1 000 mg and vitamin D3800 IU per day. The second scheme: the basic treatment was added to the drug L-carnitine 800 mg, affecting collagen formation. Self-assessment of menstrual pain was performed using McGill’s pain questionnaire. The levels of free hydroxyproline, MMP-2 and -9, tumor necrosis factor α, serum magnesium, autoantibodies IgG to cardiolipin, antinuclear antibodies were determined.

Results.In adolescent girls with DCT, the level of free blood hydroxyproline was almost two times higher than in patients with PD without DCT (276.78 ± 117.10 and 142.64 ± 90.40 ng/ml respectively to the groups; p < 0.05). In both groups, no cases of magnesium deficiency in the blood were detected. In the analysis of biochemical parameters in serum after treatment, in all groups all blood parameters significantly improved-free hydroxyproline decreased on average in 2.5 times, MMP in 3.0 times, TNF-α in 2.0 times, MMP-9 increased in 4.0 times and autoantibodies IgG to cardiolipin decreased on average in 4.0 times (p < 0.05).

Conclusions.The proposed PD therapy with NSAIDs and vitamin-mineral complex, including calcium and vitamin D, the effectiveness of which is confirmed not only by clinical data, but also by biochemical studies, it is advisable to appoint patients with PD, including those with signs of DST. The results of our own research and literature data allow us to recommend prophylactic intake of vitamin and mineral complex containing calcium and vitamin D to adolescent girls suffering from PD, to improve the quality of life, reduce the drug load and prevent reproductive disorders in the future.
Parameters of cytokine balance and vascular-epithelial growth factor depending on level of vitamin D in patients with external genital endometriosis
Authors: Akhmedova S. R. , Omarov N. S.-M.
Published: June 2020

The study was performed to find association between some cytokine status indicators, level of vascular endothelial growth factors and vitamin D in women with infertility and external genital endometriosis (EGE) in order to increase the effectiveness of its treatment. The low vitamin D status in the dynamics was determined in 240 patients aged 25 to 35 years with EGE planning pregnancy by determining the level of 25 (OH) D in the blood serum using the chemiluminescent method. Interleukin status (IL-1β, IL-6, IL-4), TNF-α, VEGFR-1 in blood serum was determined using enzyme-multiple immunoassay. The results of the studies revealed an increased level of IL-6, IL-1β and TNF-α in groups with low vitamin D content. In normal vitamin D significantly lower levels of vascular endothelial growth factor (VEGFR-1 ) in the blood serum were registered. Pregnancy rates were higher in groups with normal 25(OH)D levels in the blood serum. The mean serum VEGFR-1 level in pregnant women who became pregnant on their own was 1.3–1.5 times lower.
Placental insufficiency and fetal growth restriction: etiology, prevention, and treatment
Authors: Tapilskaya N. I. , Mel’nikov K. N. , Kuznetsova I. A. , Glushakov R. I.
Published: June 2020

The review presents modern aspects of the etiology of placental insufficiency (uteroplacental vascular insufficiency), fetal growth restriction and preeclampsia, which arises primarily due to deficient remodeling of the uterine spiral arteries supplying the placenta during early pregnancy. The embryonic, maternal and placental factors of the occurrence of placental insufficiency and placental-related pathology considered. The issues of prevention and treatment of placental insufficiency are considered taking into account the common pathogenesis of this pathological condition.
Role of molecular genetic factors in pathogenesis and diagnosis of non-alcoholic fatty liver disease (literature review and own data)
Authors: Sidorenko D. V. , Nazarov V. D. , Lapin S. V. , Emanuel V. L.
Published: June 2020

Non-alcoholic fatty liver disease is the most common liver disease, which usually has a benign course. After the occurrence of steatohepatitis the risk of developing fibrosis, cirrhosis and hepatocellular carcinoma significantly increases. At the moment, there are no reliable predictors of the aggressive course of this patients’ disease, but genetic aberrations are the most promising predictor markers. This article devoted to the role of thePNPLA3,TM6SF2,SERPINA1andHFEgenes in the pathogenesis and course of non-alcoholic fatty liver disease. Data of the prevalence of pathological alleles of these genes among patients living in St. Petersburg is also included.
Intensity of lamella growth as morphofunctional feature of human platelets
Authors: Makarov M. S.
Published: June 2020

Aim.To study morphofunctional properties of platelet lamella′s forming in donors and patients with thrombotic disorders.

Materials and methods.We studied platelets of blood donors, patients with deep venous thrombosis, burned patients with thrombotic disorders. Morphofunctional analysis was performed, using original method, based on cell vital staining.

Results. In patients with deep venous thrombosis morphofunctional platelet value was enhanced, in burned patients with thrombotic disorders platelet integrity was low. After 10–15 minutes of adhesion on glass spreading platelets maintained 3 subpopulations: cells without lamella, able to fluent granule efflux (1th type); cell with lamellipodias (2th type); cells with wide lamella, covering cell perimeter (3th type). In donors′ blood most of spreading platelets formed lamella at 1–2 hours, in patients with deep venous thrombosis this process was noticeably accelerated, estimating 30–35 minutes, what is more, spreading platelets viewed both intensive lamella′s growth and rapid degranulation of cells without lamella, followed by aggregation on the glass. Burned patients had significant decay of platelet adhesion, lamella formation was low-identified – less than 20 % of spread platelets formed lamellipodias. Among blood donors one could notice heterogeneous level of platelets, capable to rapid granules′ release during contact with adhesive substrate.

Conclusion.The lack of lamella forming may occur both at low and high morphofunctional platelet rate. During deep venous thrombosis lamella′s growth velocity was noticeably increased. Among spreading platelets with granules one could find subpopulation of cells, capable to rapid granules′ release in norm and pathology.
Place of Candida fungi in etiological structure of infectious complications in patients of oncological hospital
Authors: Tsitrenko S. A. , Lukyanova E. Yu. , Poluektova M. V. , Grivtsova L. Yu.
Published: June 2020

The article describes the spectrum of Candida fungi, isolated from hospital patients in 2018, provides an analysis of the sensitivity of Candida fungi to antifungal agents.
Hormone-microelement homeostasis of boys with obesity and delayed sexual development
Authors: Popova V. A. , Kozhin A. A. , Drukker N. A. , Selyutina S. N. , Puzikova O. Z.
Published: June 2020

The results of examinations of adolescent boys with varying degrees of obesity and delayed sexual development (DSD) showed that the content of hormones (kisspeptin, leptin, testosterone, gonadotropins, etc.) correlated with the level of essential and toxic chemical elements in urine. Correlations between urine concentrations of zinc, selenium and levels of leptin, kisspeptin and testosterone were found. This points to the etiological determinant of microelementosis in the formation of DSD in obesity in boys — possibly the effect of high lead content in urine.
Psoriasis and cardiovascular comorbidity (literature review)
Authors: Smirnova I. O. , Vladimirova I. S.
Published: June 2020

Psoriasis is a chronic immunologically associated inflammatory skin disease associated with systemic concomitant diseases, including arthritis, cardiovascular disease, kidney disease, diabetes mellitus and metabolic syndrome. The evolution of ideas about the essence of this dermatosis has led to the concept of a “psoriatic march”: psoriasis as a chronic inflammatory disease is associated with a systemic pathological process. According to numerous epidemiological studies, up to 5–7 % of the world’s population suffer from psoriasis with a continuing increase in the incidence, including severe and torpid phenotypes that lead to the most able-bodied segments of the population becoming disabled. In recent years, the question arises more often of states comorbid to psoriasis. Dermatosis is often combined with cardiovascular diseases (CVD), mental disorders, immune-mediated diseases such as Crohn’s disease, lupus erythematosus. The main factor contributing to the formation of comorbidity in psoriasis is the commonality of some links in the pathogenesis of dermatosis and the listed diseases.
Effectiveness of isotretinoin monotherapy in treatment of severe acne
Authors: Kruglova L. S. , Gryazeva N. V.
Published: June 2020

The main goal of this study was to assess the frequency of effectiveness and the tolerability of therapy in the treatment of severe acne with isotretinoin (Sotret) as monotherapy. In this study, 115 patients with severe acne were examined and treated: 107 (94.69 %) with papulo-pustular acne, 7 (6.19 %) with conglobate acne, and 1 (0.88 %) with keloid acne. Evaluation of the frequency of outcomes in the treatment of severe acne with isotretinoin Sotret was studied based on data obtained during a medical examination, which evaluated the dynamics of changes in the severity of acne according to the classification adopted by the American Academy of Dermatology (AAD, 1990) and based on data from the Assessment of Psychological and Social Effect of Acne (APSEA) Questionnaire.
Use of autologous platelet-rich plasma in treatment of genital forms of scleroatrophic lichen
Authors: Ignatovsky A. V. , Zhelonkina A. O. , Zhelonkin A. R.
Published: June 2020

The article provides an overview of the use of platelet-rich plasma (PRP) for the treatment of lichen sclerosis (LS). The definition, principle of operation and main characteristics of this method are given. Studies showing the effectiveness of PRP method were analyzed. Based on our research, we believe that PRP may be an alternative to treatment with topical corticosteroids. The method is a new treatment method for LS, which requires further randomized controlled trials.
Specificity of dermatological adverse events of BCR-ABL tyrosine kinase inhibitors and their effect on quality of life of patients with chronic myeloid leukemia
Authors: Shatokhina E. A. , Turkina A. G. , Chelysheva E. Yu. , Shukhov O. A. , Petrova A. N. , Kovrigina A. M. , Kruglova L. S. , Ranenko E. V. , Nosikova P. G.
Published: June 2020

Introduction. BCR-ABL tyrosine kinase inhibitors are currently used to successfully treat chronic myeloid leukemia (CML). Drug therapy is carried out in a continuous daily mode throughout the patient’s life. Treatment with this group of drugs is associated with specific dermatological adverse events (dAE), which can lead to a change in the regimen of effective, vital therapy for CML patients.

Purpose. To study the characteristics of dermatological adverse events, the severity and influence on the quality of life of BCR-ABL tyrosine kinase inhibitors.

Patients and methods. The observational study included 93 patients. The clinical manifestations of dAE, their severity were evaluated, their photographs and pathomorphological studies of skin biopsy samples were performed, cases of dose reduction or drug withdrawal due to dAE were recorded. The quality of life of patients with dAE was determined based on the assessment of the dermatological index of quality of life.

Results. Imatinib therapy was accompanied by a maculopapular rash in 43.3 % of patients, nilotinib caused follicular keratosis in 12.9 % of patients. In 3.2 % of patients, dasatinib caused hyperpigmentation, in 2.2 % of patients lichenoid rashes of the II degree occurred during treatment with bosutinib. Ponatinib treatment was followed by dAE in 9.7 % of patients. All dAE have an impact on the quality of life of patients, but the maculopapular rash and dyskeratotic changes are most pronounced. In a pathomorphological study, these dAE have specific features corresponding to immuno-mediated dermatitis.

Conclusions. The most frequent and pronounced dAE that significantly affect the quality of life of patients with CML are a maculopapular rash and dyskeratotic skin changes: psoriasiform and lichenoid dermatitis. Clinical and pathomorphological characteristics of skin reactions make it possible in the future to determine effective methods of supportive therapy for dAE.
On modern methods of automated diagnosis of skin tumors in clinical practice
Authors: Sergeev V. Yu. , Sergeev Yu. Yu. , Tamrazova O. B. , Nikitaev V. G. , Pronichev A. N.
Published: June 2020

Despite the existence of many algorithms for automated diagnosis of melanoma and other skin cancers, these remain almost inaccessible to public health service. A small number of publications on the efficacy of existing artificial intelligence systems marks the problems of their implementation into current examination routines in dermatology and oncology. New algorithms and software solutions as well as studies demonstrating their diagnostic accuracy on compatible and verifiable clinical material are still in demand.
Analysis of pharmacotherapy of patients with acute coronary syndrome at pre-hospital stage
Authors: Eryomina E. Yu. , Sveshnikov K. A. , Lityushkina M. I.
Published: June 2020

A patient with acute coronary syndrome requires not only urgent hospitalization, continuous medical observation, but also medical and diagnostic measures that meet standard standards.

Purpose of the study.Аnalysis of the management of patients with acute coronary syndrome with ST segments elevation in the prehospital phase.

Materials and methods.Analysis of emergency medical care patients with acute coronary syndrome with ST-segment elevation in 2017. In the study group, men (126 people) and women (119 people).

Results.The average time of arrival of the team is 14 minutes, the total time of patient care is 28.9 minutes (excluding time for delivery to the hospital). The time from the call to the moment of delivery to the emergency department is 53 minutes. Analysis of drug therapy revealed that the frequency of nitrates was 88.8 %, antiplatelet therapy – 88.2 %, narcotic analgesics – 82.3 %, anticoagulants – 67.3 %, β-blockers – 18.7 %, oxygen therapy – 36.3 %, antiarrhythmic drugs – 6.4 %, fibrinolytic therapy was performed in 54.3 % of patients.

Conclusions.А patient with acute coronary syndrome with ST elevation segments in the prehospital hospital provided sufficient medical care in accordance with clinical guidelines. A low percentage of thrombolytic therapy is associated with the presence of absolute contraindications for the patient.
State of myocardium, stiffness of vascular wall and severity of emotional disorders in patients with myocardial infarction with atrial fibrillation
Authors: Neobutov N. N. , Kolbasnikov S. V.
Published: June 2020

The widespread prevalence of myocardial infarction and the frequency of complications in the form of atrial fibrillation, makes it relevant to study its pathogenesis and effect on hemodynamics, significantly aggravating the patient’s condition, leading to a deterioration in hemodynamic parameters and the appearance of recurrent myocardial ischemia. At present, a large amount of data has been accumulated on the causes, electrophysiological mechanisms, and hemodynamic consequences of the development of atrial fibrillation during myocardial infarction. This circumstance necessitates both further study of the features of the development and course of atrial fibrillation, and the search for new approaches in organizing and optimizing the treatment of this complication. It is necessary to study in detail the structure of anxiety-depressive disorders, the state of the elastotonic properties of the vascular wall, endothelial function and heart remodeling in patients with myocardial infarction with various forms of atrial fibrillation.
Use of amlodipine + ramipril single-pill combination for prevention of stroke in hypertension patient (clinical case)
Authors: Ostroumova O. D. , Butorov V. N. , Kochetkov A. I.
Published: June 2020

Arterial hypertension is one of the most significant modifiable risk factors for stroke. The article provides a clinical example of using a fixed combination of amlodipine + ramipril in real clinical practice in a patient suffering from arterial hypertension, occurring with dyslipidemia, hyperuricoemia, microalbuminuria. High antihypertensive activity of a fixed combination of amlodipine + ramipril was shown. A literature review of the beneficial effect of amlodipine and lisinopril on the risk of stroke, as well as the beneficial effect of this combination of drugs on the course of chronic kidney disease developing in patients with arterial hypertension, is presented.
Radiation therapy in treatment of patients with meningeal hemangiopericytoma (solitary fibrous) tumor of dura mater
Authors: Nazarenko A. V. , Borisova T. N. , Romanov D. S. , Medvedev S. V. , Tkachyov S. I. , Gerasimov Yu. A. , Bekyashev A. Kh. , Mitrofanov A. A. , Boldyreva A. V. , Fedoseenko D. I.
Published: June 2020

Tactics of treating patients with meningeal hemangiopericytoma, or a solitary fibrous tumor of the dura mater remains controversial due to their rarity and heterogeneity of global experience, however, analysis of clinical data indicates that the best results are achieved when performing a total removal of the primary tumor and then following a course of external-beam radiation therapy on surgical bed in adequate total doses.
Diagnosis of thoracic aortic diseases. Part 2. Visualization methods in acute aortic syndromes and traumatic injuries
Authors: Bartosh-Zelenaya S. Yu. , Naiden T. V.
Published: June 2020

Current review article focuses on the diagnostic aspects of acute aortic syndromes and traumatic injuries. In each case, the etiology of the disease, diagnostic competence of echocardiography (both transthoracic and transesophageal) are considered as the first line diagnostic mean; also diagnostic possibilities of other methods are discussed (such as CT scan, magnetic resonance imaging).
Standardization of spirometry: what’s new in 2019 update. Part 1
Authors: Kiryukhina L. D. , Struchkov P. V.
Published: June 2020

Spirometry is the basic method for pulmonary function evaluating but it is very dependent on the quality of performance. Currently, specialists in lung function diagnostics rely on the 2005 technical standards of spirometry, jointly developed by the American thoracic Society (ATS) and the European Respiratory Society (ERS), adapted for our country by the Russian Respiratory Society in 2013. New technical capabilities and research studies have shown the need to improve approaches to ensuring the measurements quality. A joint task force with experience in conducting and analyzing pulmonary functional tests assigned by the ATS and ERS has significantly updated international standards to ensure quality laboratory practice. The article discusses the standards update by the 2019 consensus, as well as the new added factors that were not previously mentioned. New standards are needed for manufacturers, clinicians, functional diagnostics specialists and researchers in order to increase the accuracy of spirometric measurements and reduce the negative impact on the patient.
4-6 Yaş Kur’an Kursu Öğreticilerinin Eğitsel Yeterlikleri ve Görev Yaptıkları Kurslarla İlgili Görüşleri
Authors: Üzümcü Muzaffer , Çınar Nuran
Published: June 2020

Bu çalışmanın amacı, Diyanet İşleri Başkanlığı 4-6 Yaş Kur’ân Kurslarında görev yapan öğreticilerin 4-6 yaş Kur’an Kursu Programı’yla ilgili görüşlerini tespit ederek değerlendirmektir. Bireyin dinî gelişim sürecinin zeminini ve kritik noktalarını ihtiva eden okul öncesi dönem, din eğitimi çalışmaları için özel bir yere sahiptir. Ancak bu dönemde verilecek din eğitiminin resmî olarak ele alınması ülkemiz eğitim tarihinde -diğer eğitim kademelerine göre- oldukça geç bir tarihe rastlamaktadır. Okul öncesi dönemindeki çocuklara yönelik din eğitimi, Diyanet Dört-Altı Yaş Kur’ân Kursu Programının 2013-2014 eğitim-öğretim yılında on ilde pilot olarak -bir sonraki yıl ise tüm Türkiye’de- uygulanmaya başlamasıyla ilk kez resmî olarak gündeme gelmiştir. Programın uygulanma tecrübesinden elde edilen veriler, programın niteliğini arttırmak için önemlidir. 4-6 yaş dönemindeki çocukların zihin dünyasını keşfetme ve herhangi bir konuyla ilgili reflektif beyanlarını alabilme zorluğu, bu programı uygulayan öğreticilerin gözlem ve görüşlerini önemli bir bilgi kaynağı haline getirmektedir. Bu öneme binaen Tekirdağ’ın Çorlu ilçesinde görev yapan 27 öğreticiyle 2018 yılı Aralık ayında odak grup görüşmesi gerçekleştirilmiştir. Öğreticilerin kendi meslekî yeterliliklerine ve görev yaptıkları kurslara dair dile getirdikleri görüşleri belirlenen temalar altında değerlendirilmiştir.
Temperature Effects on Polymer-Ceramic Pressure-Sensitive Paint as a Luminescent Pressure Sensor
Authors: Hayashi Tatsunori , Sakaue Hirotaka
Published: June 2020

Polymer-ceramic pressure-sensitive paint (PC-PSP) has been used for capturing unsteady pressure over aerodynamic surfaces. Spatial and temporal pressure information is calculated from the luminescent intensity produced by a PC-PSP, which provides a nonintrusive pressure measurement. Despite its benefits, the temperature dependency of PC-PSP makes extraction of quantitative pressure data challenging. The temperature dependency in terms of the static and dynamic characteristics of a ruthenium-based PC-PSP is studied herein. The impact of temperature dependency on PC-PSP characteristics is also discussed in the context of an unsteady pressure measurement.
In Vitro and In Vivo Study on Humans of Natural Compound Synergy as a Multifunctional Approach to Cellulite-Derived Skin Imperfections
Authors: Nobile Vincenzo , Cestone Enza , Puoci Francesco , Deponti Ileana , Pisati Marta , Michelotti Angela
Published: June 2020

Aim: The present study aimed to assess the efficacy of a nutraceutical ingredient, SelectSIEVE® Rainbow, based on botanical extracts, in ameliorating cellulite-derived skin imperfections and microcirculation. The nutritional supplement contained a mixture of Oryza sativa (L.), Citrus sinensis (L.) Osbeck, Ananas comosus (L.) Merr, and Actinidia chinensis Planch; all ingredients were botanicals that can be used in food supplements. Results: In vitro studies showed the high capacity of the supplement to have an anti-inflammatory, antioxidant, and hypolipidemic effect, accompanied by an interesting proteolytic activity. The randomized double-blind placebo-controlled clinical trial, carried out on 60 women during an 8-week treatment period, confirmed the in vitro study results. SelectSIEVE® Rainbow showed a whole-body shaping activity, with a reduction of the waist, hip, and tight circumference of 0.8, 0.65 and 0.72 cm, respectively. It also showed a reduction of subcutaneous fat mass of 1.24 mm and body weight, with an average of 0.7 kg and positive peaks of −2.9 kg. Skin health and appearance were also improved: +5.4% skin elasticity, +5.5% skin tonicity and +5.7% skin draining. Finally, the dermatological evaluation of the cellulite score and microcirculation showed an improvement in 57% and 60% of the subjects enrolled in the studies. Conclusions: This first study provides interesting inputs on the effectiveness of the nutraceutical complex standardized in polyphenols, anthocyanins and proteolytic enzymes to counteract cellulite blemishes and improve local microcirculation. The positive response encourages deeper studies and further investigation.
Exploring the Interrelationship between Additive Manufacturing and Industry 4.0
Authors: Butt Javaid
Published: June 2020

Innovative technologies allow organizations to remain competitive in the market and increase their profitability. These driving factors have led to the adoption of several emerging technologies and no other trend has created more of an impact than Industry 4.0 in recent years. This is an umbrella term that encompasses several digital technologies that are geared toward automation and data exchange in manufacturing technologies and processes. These include but are not limited to several latest technological developments such as cyber-physical systems, digital twins, Internet of Things, cloud computing, cognitive computing, and artificial intelligence. Within the context of Industry 4.0, additive manufacturing (AM) is a crucial element. AM is also an umbrella term for several manufacturing techniques capable of manufacturing products by adding layers on top of each other. These technologies have been widely researched and implemented to produce homogeneous and heterogeneous products with complex geometries. This paper focuses on the interrelationship between AM and other elements of Industry 4.0. A comprehensive AM-centric literature review discussing the interaction between AM and Industry 4.0 elements whether directly (used for AM) or indirectly (used with AM) has been presented. Furthermore, a conceptual digital thread integrating AM and Industry 4.0 technologies has been proposed. The need for such interconnectedness and its benefits have been explored through the content-centric literature review. Development of such a digital thread for AM will provide significant benefits, allow companies to respond to customer requirements more efficiently, and will accelerate the shift toward smart manufacturing.
Lognormality in Turbulence Energy Spectra
Authors: Lee Taewoo
Published: June 2020

The maximum entropy principle states that the energy distribution will tend toward a state of maximum entropy under the physical constraints, such as the zero energy at the boundaries and a fixed total energy content. For the turbulence energy spectra, a distribution function that maximizes entropy with these physical constraints is a lognormal function due to its asymmetrical descent to zero energy at the boundary lengths scales. This distribution function agrees quite well with the experimental data over a wide range of energy and length scales. For turbulent flows, this approach is effective since the energy and length scales are determined primarily by the Reynolds number. The total turbulence kinetic energy will set the height of the distribution, while the ratio of length scales will determine the width. This makes it possible to reconstruct the power spectra using the Reynolds number as a parameter.
Compact Thermal Modeling of Modules Containing Multiple Power LEDs
Authors: Janicki Marcin , Ptak Przemysław , Torzewicz Tomasz , Górecki Krzysztof
Published: June 2020

Temperature is an essential factor affecting the operation of light-emitting diodes (LEDs), which are often used in circuits containing multiple devices influencing each other. Therefore, the thermal models of such circuits should take into account not only the self-heating effects, but also the mutual thermal influences among devices. This problem is illustrated here based on the example of a module containing six LEDs forming on the substrate a hexagon. This module is supposed to operate without any heat sink in the natural convection cooling conditions, hence it has been proposed to increase the thermal pad area in order to lower the device-operating temperature. In the experimental part of the paper, the recorded diode-heating curves are processed using the network identification by deconvolution method. This allows for the computation of the thermal time constant spectra and the generation of device-compact thermal models. Moreover, the influence of the thermal pad surface area on the device temperature and the thermal coupling between LEDs is investigated.
Study of Enhanced Oil Recovery and Adsorption Using Glycerol in Surfactant Solution
Authors: Curbelo Fabiola D. S. , Garnica Alfredo Ismael C. , Leite Danilo F. Q. , Carvalho Amanda B. , Silva Raphael R. , Paiva Evanice M.
Published: June 2020

Over time, oil production in a reservoir tends to decrease, which makes it difficult to flow through the reservoir to the well, making its production increasingly difficult and costly. Due to their physical properties, such as reducing the water/oil interfacial tension, surfactants have been used in enhanced oil recovery (EOR) processes, however, their adsorption presents as an undesirable and inevitable factor and can decrease the efficiency of the method. This work’s main objective is to evaluate the effect of glycerol in the adsorption of surfactants in sandstones, as well as in the recovery factor during EOR. Brine solutions containing the nonionic surfactant saponified coconut oil (SCO), with and without glycerol, were used in the adsorption and oil recovery tests in sandstone. Adsorption, recovery, rheological, and thermogravimetric analysis were carried out. Regarding the surfactant/glycerol/brine solution, there was an improvement in the oil mobility, as the glycerol contributed to an increase in the viscosity of the solution, thereby increasing the sweep efficiency. The recovery factor obtained for the surfactant solution with glycerol was satisfactory, being 53% higher than without glycerol, because it simultaneously provided an increase in viscosity and a decrease in interfacial tension, both of which are beneficial for the efficiency of the process.
Hedging Strategies of Green Assets against Dirty Energy Assets
Authors: Saeed Tareq , Bouri Elie , Tran Dang Khoa
Published: June 2020

Previous studies argue that the relationships between clean/green and dirty energy assets are time-varying, but there is a lack of evidence on the hedging ability of clean energy stocks and green bonds for dirty assets, such as crude oil and an energy stock index exchange traded fund (ETF), and the portfolio implications. Furthermore, potential drivers of the dynamics of the hedge portfolio returns are still unknown. To address these research gaps, the authors provide an extensive analysis of the hedging ability of clean/green assets against two dirty energy assets (crude oil prices and energy ETF) using daily data from 3 January 2012 to 29 November 2019. Using corrected dynamic conditional correlation models, the authors model correlation and then compute hedge ratios and hedging effectiveness, which all seem to vary with time. The results from hedging effectiveness indicate that investors should follow a dynamic hedging strategy and that clean energy stocks are more effective hedge than green bonds, especially for crude oil. The application of regression analyses shows that the implied volatilities of US equities and crude oil as well as US dollar index have a negative impact on the hedge portfolio returns, whereas gold prices and inflation have a positive impact.
A Comprehensive Review of Strategies and Approaches for Enhancing the Performance of Thermoelectric Module
Authors: Lv Song , Qian Zuoqin , Hu Dengyun , Li Xiaoyuan , He Wei
Published: June 2020

In recent years, thermoelectric (TE) technology has been emerging as a promising alternative and environmentally friendly technology for power generators or cooling devices due to the increasingly serious energy shortage and environmental pollution problems. However, although TE technology has been found for a long time and applied in many professional fields, its low energy conversion efficiency and high cost also hinder its wide application. Thus, it is still urgent to improve the thermoelectric modules. This work comprehensively reviews the status of strategies and approaches for enhancing the performance of thermoelectrics, including material development, structure and geometry improvement, the optimization of a thermal management system, and the thermal structure design. In particular, the influence of contact thermal resistance and the improved optimization methods are discussed. This work covers many fields related to the enhancement of thermoelectrics. It is found that the main challenge of TE technology remains the improvement of materials’ properties, the decrease in costs and commercialization. Therefore, a lot of research needs to be carried out to overcome this challenge and further improve the performance of TE modules. Finally, the future research direction of TE technology is discussed. These discussions provide some practical guidance for the improvement of thermoelectric performance and the promotion of thermoelectric applications.
A Real-Time Dynamic Fuel Cell System Simulation for Model-Based Diagnostics and Control: Validation on Real Driving Data
Authors: Ritzberger Daniel , Hametner Christoph , Jakubek Stefan
Published: June 2020

Fuel cell systems are regarded as a promising candidate in replacing the internal combustion engine as a renewable and emission free alternative in automotive applications. However, the operation of a fuel cell stack fulfilling transient power-demands poses significant challenges. Efficiency is to be maximized while adhering to critical constraints, avoiding adverse operational conditions (fuel starvation, membrane flooding or drying, etc.) and mitigating degradation as to increase the life-time of the stack. Owing to this complexity, advanced model-based diagnostic and control methods are increasingly investigated. In this work, a real time stack model is presented and its experimental parameterization is discussed. Furthermore, the stack model is integrated in a system simulation, where the compressor dynamics, the feedback controls for the hydrogen injection and back-pressure valve actuation, and the purging strategy are considered. The resulting system simulation, driven by the set-point values of the operating strategy is evaluated and validated on experimental data obtained from a fuel cell vehicle during on-road operation. It will be shown how the internal states of the fuel cell simulation evolve during the transient operation of the fuel cell vehicle. The measurement data, for which this analysis is conducted, stem from a fuel cell research and demonstrator vehicle, developed by a consortium of several academic and industrial partners under the lead of AVL List GmbH.