bluuebunny/crossref_metadata_2025 huggingface dataset:
Objetivos do milênio e democracia construtiva: os direitos fundamentais como elementos constitutivos do Estado Democrático de Direito
Authors: Coutinho Carlos Marden Cabral , Morais Jose Luis Bolzan de
Published: July 2016

O presente trabalho tem por objetivo demonstrar como a realização dos Objetivos do Milênio se apresenta como um pressuposto para a construção do Estado Democrático de Direito. Para tanto, apresentar-se-á inicialmente uma discussão a respeito do conceito de democracia, com o intuito de demonstrar que (em pleno século XXI) a democracia não pode mais ser vista como um direito limitado de participação política, devendo ser entendida como a capacidade que cada um tem de construir a própria realidade. A partir de tal conceito, buscar-se-á superar o paradigma da democracia liberal clássica, mediante a exposição da lógica segundo a qual o processo ativo da democracia exige que cada pessoa tenha efetiva capacidade de exercer a sua cidadania, o que depende de que lhe sejam oferecidas uma série de oportunidades essenciais para o seu desenvolvimento. Nesse contexto, expor-se-á que os Objetivos do Milênio se destacam, na medida em que representam elementos mínimos de condições de uma vida digna, sem os quais se mostra inviável se falar em construção da própria realidade. Por fim, sustentar-se-á que o compromisso com o cumprimento dos Objetivos do Milênio se confunde parcialmente com o compromisso de concretizar o Estado Democrático de Direito, na medida em que representa um passo adequado na ampliação da capacidade de participação efetiva das pessoas que compõem determinada sociedade.
O caminho da inclusão de pessoas com deficiência no mercado de trabalho: onde estamos?
Authors: Silva Alexandre Antonio Bruno da , Leitão André Studart , Dias Eduardo Rocha
Published: July 2016

Nas últimas décadas, organizações internacionais, entes estatais, organizações não governamentais e a sociedade como um todo, lançou seu olhar para a luta travada pelos deficientes, almejando sua inclusão social. Uma série de documentos internacionais foram criados, visando não só melhorar as condições de vida do deficiente, mas colocar em pauta inclusão social. Cada ser humano tem o direito de desfrutar de todas as condições necessárias para o desenvolvimento de seus talentos e aspirações. O deficiente deve ter ao seu dispor condições especiais, além da proteção garantida a todos, que minimizem ou eliminem as barreiras para a sua vida em sociedade. A Convenção sobre os Direitos das Pessoas com Deficiência, ratificada pelo Brasil, teve como propósito maior promover, proteger e assegurar o pleno exercício dos direitos humanos das pessoas com deficiência, demandando dos Estados-partes medidas legislativas e administrativas. No âmbito legislativo brasileiro, após várias normas tratando do assunto, foi instituída a Lei Brasileira de Inclusão da Pessoa com Deficiência (Estatuto da Pessoa com Deficiência). Certamente, apesar de sua importância, a legislação não tem o poder de transformar rapidamente o comportamento da sociedade. São necessárias políticas públicas, já previstas no próprio Estatuto, para estimular e acompanhar esse processo. A inclusão do deficiente no mundo do trabalho é uma das mais importantes vertentes desse esforço. Através dos números obtidos pelos sistemas de estatística existentes é possível: analisar o grau de sucesso, verificar onde as políticas públicas de inclusão apresentam falhas e sugerir mudanças.
A dimensão democrática do dever de motivação das decisões judiciais: o novo código de processo civil como concretização da Constituição de 1988
Authors: Montedonio Rego Frederico
Published: July 2016

O atual debate sobre os “novos” requisitos para a fundamentação das decisões judiciais, previstos no artigo 489 do novo Código de Processo Civil (Lei nº 13.105/2015), embora particularmente acirrado no contexto de uma sociedade brasileira hiperjudicializada, perde relevância ao se constatar que a maior parte daquelas exigências decorre da própria natureza de um regime que se pretende democrático. Depois de analisar sucintamente a fonte da legitimidade democrática do Poder Judiciário, o estudo traça um breve paralelo entre as trajetórias históricas da democracia e da fundamentação das decisões judiciais, ambas marcadas por triunfos e usos simbólicos. Em seguida, o dever de motivação das decisões judiciais é associado com alguns conceitos-chave da democracia, como igualdade e soberania popular, publicidade, participação, Estado de Direito e deliberação. À vista disso, o novo dispositivo processual pode ser apresentado em boa medida como uma concretização daquilo que já poderia ser extraído da Constituição de 1988. A conclusão aponta para a validade do dispositivo, num esforço de aprofundamento da democracia que, embora disputada por teorias agregativas, deliberativas e agonistas, continua sendo a utopia do século XXI.
Sustentabilidade empresarial: análise comparativa da disciplina jurídica dos informes não financeiros (Brasil e União Europeia)
Authors: Chaves Vinicius Figueiredo , Flores Nilton Cesar Da Silva
Published: July 2016

A partir do referencial teórico da sustentabilidade, o artigo analisa a questão da incorporação de considerações de ordem social e ambiental aos negócios e operações desenvolvidos pelas empresas, mediante a disseminação pública de suas performances nessas áreas. A pesquisa, qualitativa, com perfil exploratório, baseada nas técnicas de revisão bibliográfica e documental, assim como no levantamento de dados, é realizada com o objetivo de identificar e analisar comparativamente o tratamento normativo conferido à temática da divulgação pública de relatórios não financeiros (os chamados informes ou relatórios de sustentabilidade), segundo as perspectivas brasileira e europeia. Percebeu-se que, no Brasil, não há obrigação legal de publicação de informes sobre sustentabilidade, mas a divulgação é recomendada às empresas pela BM&FBOVESPA (instituição administradora do mercado de capitais), desde dezembro de 2011, por meio de instrumento que caracteriza direito brando/flexível. Por outro lado, no âmbito da União Europeia (UE), reconheceu-se a necessidade de melhorar a transparência da informação social e ambiental por parte de certas sociedades empresárias e grupos de empresas, elemento considerado indispensável para a sua responsabilidade social. Nesse sentido, foram editadas diretivas (2013/2014) do Parlamento Europeu e do Conselho da União Europeia, no que diz respeito ao tema da divulgação de informações não financeiras. Os atos legislativos em questão têm como destinatários todos os Estados-membros da UE, obrigando-os a intervir nas estruturas jurídicas nacionais (direito “forte”) de forma a transpor, para os respetivos ordenamentos, em caráter obrigatório e dentro de um prazo determinado, as normas gerais que consagram determinados parâmetros comuns sobre o tema.
A ineficácia da tutela multinível dos direitos dociais na União Europeia
Authors: Silva Alice Rocha da , Silva Matheus Passos
Published: July 2016

A existência de três níveis distintos de proteção dos direitos sociais na União Europeia – internacional, regional e nacional - leva à pressuposição de que existem inúmeras vantagens em tal arranjo jurídico. De maneira sintética, pode-se afirmar que existiria uma verdadeira complementaridade entre tais sistemas, já que as insuficiências de um poderiam ser sanadas por outro. Contudo, o sistema envolve riscos, especialmente quando se considera que tais ordens jurídicas, por serem distintas, nem sempre estarão em harmonia, ainda que se utilizem dos mesmos conceitos. Neste sentido, o objetivo deste texto é o de analisar alguns riscos em relação à tutela multinível dos direitos fundamentais, com foco nos direitos sociais. Para tanto parte-se da metodologia de analise do surgimento da tutela multinível dos direitos fundamentais e de sua conceituação teórica, para em seguida serem apresentados os riscos da tutela multinível, especialmente aqueles decorrentes da falta de diálogo judicial entre os tribunais envolvidos.
Detecting variable responses in time-series using repeated measures ANOVA: Application to physiologic challenges
Authors: Macey Paul M. , Schluter Philip J. , Macey Katherine E. , Harper Ronald M.
Published: July 2016

We present an approach to analyzing physiologic timetrends recorded during a stimulus by comparing means at each time point using repeated measures analysis of variance (RMANOVA). The approach allows temporal patterns to be examined without an a priori model of expected timing or pattern of response. The approach was originally applied to signals recorded from functional magnetic resonance imaging (fMRI) volumes-of-interest (VOI) during a physiologic challenge, but we have used the same technique to analyze continuous recordings of other physiological signals such as heart rate, breathing rate, and pulse oximetry. For fMRI, the method serves as a complement to whole-brain voxel-based analyses, and is useful for detecting complex responses within pre-determined brain regions, or as a post-hoc analysis of regions of interest identified by whole-brain assessments. We illustrate an implementation of the technique in the statistical software packages R and SAS. VOI timetrends are extracted from conventionally preprocessed fMRI images. A timetrend of average signal intensity across the VOI during the scanning period is calculated for each subject. The values are scaled relative to baseline periods, and time points are binned. In SAS, the procedure PROC MIXED implements the RMANOVA in a single step. In R, we present one option for implementing RMANOVA with the mixed model function “lme”. Model diagnostics, and predicted means and differences are best performed with additional libraries and commands in R; we present one example. The ensuing results allow determination of significant overall effects, and time-point specific within- and between-group responses relative to baseline. We illustrate the technique using fMRI data from two groups of subjects who underwent a respiratory challenge. RMANOVA allows insight into the timing of responses and response differences between groups, and so is suited to physiologic testing paradigms eliciting complex response patterns.
Molecular docking and molecular dynamics simulation study of inositol phosphorylceramide synthase – inhibitor complex in leishmaniasis: Insight into the structure based drug design
Authors: Mandlik Vineetha , Singh Shailza
Published: July 2016

Inositol phosphorylceramide synthase (IPCS) has emerged as an important, interesting and attractive target in the sphingolipid metabolism of Leishmania. IPCS catalyzes the conversion of ceramide to IPC which forms the most predominant sphingolipid in Leishmania. IPCS has no mammalian equivalent and also plays an important role in maintaining the infectivity and viability of the parasite. The present study explores the possibility of targeting IPCS; development of suitable inhibitors for the same would serve as a treatment strategy for the infectious disease leishmaniasis. Five coumarin derivatives were developed as inhibitors of IPCS protein. Molecular dynamics simulations of the complexes of IPCS with these inhibitors were performed which provided insights into the binding modes of the inhibitors. In vitro screening of the top three compounds has resulted in the identification of one of the compounds (compound 3) which shows little cytotoxic effects. This compound therefore represents a good starting point for further in vivo experimentation and could possibly serve as an important drug candidate for the treatment of leishmaniasis.
THE ADMINISTRATIVE AND LEGAL CHARACTERISTIC OF COMPETENCE OF THE RUSSIAN PRESIDENT, FEDERAL ASSEMBLY OF THE RUSSIAN FEDERATION AND THE GOVERNMENT OF THE RUSSIAN FEDERATION IN THE SPHERE OF MANAGEMENT OF CIVIL AVIATION IN RUSSIA
Authors: Шустова Мария , Shustova Mariya
Published: July 2016

In the scientific article organizational and legal aspects of realization of competence of the Russian President, Federal Assembly of the Russian Federation and the Government of the Russian Federation in the sphere of management of civil aviation in Russia as most important part of domestic economy are analyzed. The positions of

the leading scientists connected with disclosure of the maintenance of

the basic concepts used in the field are considered. The perspective of

functioning and development of air transport is considered.
Learning to Manage and Managing to Learn: The Effects of Student Leadership Service
Authors: Anderson Michael L. , Lu Fangwen
Published: July 2016

Employers and colleges value individuals with leadership service, but there is limited evidence on whether leadership service itself creates skills. Identification in this context has proved difficult because settings in which leadership service accrues to individuals for ostensibly random reasons are rare. In this study we estimate the effects of random assignment to classroom leadership positions in a Chinese secondary school. We find that leadership service increases test scores, increases students’ political popularity in the classroom, makes students more likely to take initiative, and shapes students’ beliefs about the determinants of success. The results suggest that leadership service may impact human capital and is not solely a signal of preexisting skills.

Data are available at http://dx.doi.org/10.1287/mnsc.2016.2483 .

This paper was accepted by John List, behavioral economics.
Network Pricing of Congestion-Free Networks: The Elastic and Linear Demand Case
Authors: Kuiteing Aimé Kamgaing , Marcotte Patrice , Savard Gilles
Published: July 2016

In this work, we address the problem of maximizing the revenue raised from tolls set on a multicommodity transportation network, taking into account that users are assigned to cheapest paths, and that demand is a linearly decreasing function of total path cost (initial cost of carrying the products plus toll). We propose for its numerical solution three mixed quadratic formulations, either in arc or path flow space. Similar to what was achieved in the fixed demand case, we analyze the structure and properties of the problem, including its theoretical complexity. On the computational side, we analyze the sensitivity of central processing unit time with respect to two key parameters, namely, demand elasticity and percentage of toll arcs.
Genomic evidence of adaptive evolution in emergent Vibrio parahaemolyticus ecotypes
Authors: Turner Jeffrey W. , Berthiaume Chris T. , Morales Rhonda , Armbrust E. Virginia , Strom Mark S.
Published: July 2016

The ubiquitous marine bacterium Vibrio parahaemolyticus is a leading cause of illness associated with seafood consumption. The emergence of two genetically distinct ecotypes (ST3 and ST36) has led to an alarming increase in the size and frequency of disease outbreaks. We conducted a genomic comparison of 30 V. parahaemolyticus genomes that represent a diverse collection of 15 genetically distinct ecotypes, including newly sequenced representatives of ST3 and ST36, isolated from both clinical and environmental sources. A multistep evolutionary analysis showed that genes associated with sensing and responding to environmental stimuli have evolved under positive selection, identifying examples of convergent evolution between ST3 and ST36. A comparison of predicted proteomes indicated that ST3 and ST36 ecotypes laterally acquired tens of novel genes associated with a variety of functions including dormancy, homeostasis and membrane transport. Genes identified in this study play an apparent role in environmental fitness and may confer cross protection against stressors encountered in the human host. Together, these results show the evolution of stress response is an important genetic mechanism correlated with the recent emergence of the ST3 and ST36 ecotypes.
Intertrigo: the hidden face of canine atopic dermatitis
Authors: Scarff David
Published: July 2016

Canine atopic dermatitis is frequently accompanied by intertrigo (skin fold dermatitis). This can cause significant clinical signs including pruritus, odour and pain in affected skin folds. Control of the underlying atopic dermatitis alone may not be enough to resolve these signs. This paper discusses the presentation, diagnosis and management of this common problem.
Early progressive mobilisation following acute subarachnoid or subdural haemorrhage: An observational pilot study
Authors: O'Shea Kristie , Stiller Kathy
Published: July 2016

Background/Aims:

There is little research regarding early mobilisation following non-traumatic acute subarachnoid (SAH) or subdural haemorrhage (SDH). The aim of this prospective observational study was to document the feasibility and safety of our usual practice regarding the early progressive mobilisation of patients following acute SAH or SDH.

Method:

Mobilisation was defined as sitting on the edge of the bed or greater. All participants were screened regarding their suitability for mobilisation to commence/continue.

Results:

Fifty participants were included: 42 mobilised at least once as part of their physiotherapy intervention. The 50 participants received a total of 373 physiotherapy sessions, with mobilisation occurring during 50% of sessions. Neurological reasons most frequently prevented mobilisation. All 42 participants who mobilised at least once achieved the mobility milestone of sitting on the edge of the bed and 86% progressed to walking, usually by 4–5 days post-admission. Poor neurological status on admission was associated with delayed achievement of mobility milestones. Adverse events associated with mobilisation were infrequent (1.6%), transient and self-limiting.

Conclusion:

Following appropriate screening, early progressive mobilisation of patients following non-traumatic acute SAH or SDH was feasible and safe. Further research is required to confirm its safety and benefits, and establish the most effective dose.
Pain recognition in reptiles and investigation of associated behavioural signs
Authors: Ayers Hayley
Published: July 2016

Background:

There is minimal research into reptile pain management and analgesic protocols, and current opinions surrounding this topic are outdated; the last significant study was carried out by Read in 2004. The aim of this current study was to consider the current ideas and highlight any advancements in reptile analgesia.

Objective:

To investigate current ideas within analgesia in reptiles, with focus on the creation of a behavioural ethogram for clinical reference.

Methods:

A survey was created using an online platform and distributed to experts in the field of reptile pain management (veterinarians and veterinary nurses) as well as experienced animal carers (herpetoculturists and pet owners).

Results:

A chi-square test revealed no statistical significance in behavioural signs recognised between veterinary professionals and animal carers. Continuity existed between the behavioural signs recognised by both expert groups.

Conclusion:

A lack of confidence was identified when assessing pain in reptiles. The top three behavioural signs of pain in the three subgroups were statistically agreed on across both groups of expert individuals, indicating a good basis for a behavioural ethogram.
The medial and lateral epicondyle as a reliable landmark for intra-operative joint line determination in revision knee arthroplasty
Authors: Ozkurt B. , Sen T. , Cankaya D. , Kendir S. , Basarır K. , Tabak Y.
Published: July 2016

Objectives

The purpose of this study was to develop an accurate, reliable and easily applicable method for determining the anatomical location of the joint line during revision knee arthroplasty.

Methods

The transepicondylar width (TEW), the perpendicular distance between the medial and lateral epicondyles and the distal articular surfaces (DMAD, DLAD) and the distance between the medial and lateral epicondyles and the posterior articular surfaces (PMAD, DLAD) were measured in 40 knees from 20 formalin-fixed adult cadavers (11 male and nine female; mean age at death 56.9 years, sd 9.4; 34 to 69). The ratios of the DMAD, PMAD, DLAD and PLAD to TEW were calculated.

Results

The mean TEW, DMAD, PMAD, DLAD and PLAD were 82.76 mm (standard deviation (sd) 7.74), 28.95 mm (sd 3.3), 28.57 mm (sd 3), 23.97 mm (sd 3.27) and 24.42 mm (sd 3.14), respectively. The ratios between the TEW and the articular distances (DMAD/TEW, DLAD/TEW, PMAD/TEW and PLAD/TEW) were calculated and their means were 0.35 (sd 0.02), 0.34 (sd 0.02), 0.28 (sd 0.03) and 0.29 (sd 0.03), respectively.

Conclusion

This method provides a simple, reproducible and reliable technique enabling accurate anatomical joint line restoration during revision total knee arthroplasty. Cite this article: B. Ozkurt, T. Sen, D. Cankaya, S. Kendir, K. Basarır, Y. Tabak. The medial and lateral epicondyle as a reliable landmark for intra-operative joint line determination in revision knee arthroplasty. Bone Joint Res 2016;5:280–286. DOI: 10.1302/2046-3758.57.BJR-2016-0002.R1.
Collecting, Integrating, and Disseminating Patient-Reported Outcomes for Research
in a Learning Healthcare System
Authors: Harle Christopher A. , Lipori Gloria , Hurley Robert W.
Published: July 2016

Introduction: Advances in health policy, research, and information technology have
converged to increase the electronic collection and use of patient-reported outcomes
(PROs). Therefore, it is important to share lessons learned in implementing PROs in
research information systems.Case Description: The purpose of this case study is to
describe a novel information system for electronic PROs and lessons learned in
implementing that system to support research in an academic health center. The system
incorporates freely available and commercial software and involves clinical and research
workflows that support the collection, transformation, and research use of PRO data. The
software and processes that comprise the system serve three main functions, (i)
collecting electronic PROs in clinical care, (ii) integrating PRO data with non-patient
generated clinical data, and (iii) disseminating data to researchers through the
institution’s research informatics infrastructure, including the i2b2 (Informatics for
Integrating Biology and the Bedside) system.Strategies: Our successful design and
implementation was driven by three overarching strategies. First, we selected and
implemented multiple interfaced technologies to support PRO collection, management, and
research use. Second, we aimed to use standardized approaches to measuring PROs, sending
PROs between systems, and disseminating PROs. Finally, we focused on using technologies
and processes that aligned with existing clinical research information management
strategies within our organization.Conclusion: These experiences and lessons may help
future implementers and researchers enhance the scale and sustainable use of systems for
research use of PROs.
Committee scrutiny in Scotland: a comparative and bi-constitutional perspective
Authors: Cole Michael
Published: July 2016

This article addreses scrutiny undertaken through departmental committees at the Scottish Parliament. The analysis is addressed through four distinctive phases – choice, evidence-gathering, evaluation and outputs – developed through using a wide-ranging comparative literature. The findings on Scotland are discussed in terms of the bi-constitutional perspective and specifically the emergence of different forms of committee scrutiny at the Scottish Parliament and the UK House of Commons. This analysis is subsequently widened through reference to committee scrutiny at the Northern Ireland Assembly and the National Assembly for Wales. Finally, wider applications are identified.
The virtues and vices of resigning from office
Authors: Hatier Cécile
Published: July 2016

Resigning from office can have a deeply moral dimension, whether to make amends for an unethical deed or to avoid having to carry one out. It is therefore no surprise that those calling for a restoration of morality in public affairs should stress the virtues of resigning. Is it always morally responsible to resign on ethical grounds, however? This paper argues against this Manichean stance. Instead, loosely borrowing from Aristotle’s theory of the mean, it asserts the proximity of vice and virtue in many instances, rendering the decision-making process more complex than following some simple ethical rules.
Northern Ireland: where is the peace dividend?
Authors: Knox Colin
Published: July 2016

Northern Ireland has been described as a ‘post conflict’ society with a stable political environment following the peace process, and yet it is a hugely segregated society with significant social deprivation. With peace came the promise of a ‘peace dividend’ for those most affected by the violence. This paper uses the Department for International Development's (DFID) ‘state building for peace’ model as a way of understanding and analysing the fragility of the peace process, in particular how the Northern Ireland Executive, in order to maintain legitimacy and stability, has failed to meet public expectations to improve the quality of their lives.
Social circus in the Arctic: Cultivating resilience
Authors: Lavers Katie , Burtt Jon
Published: July 2016

Between 2010 and 2013, social circus instructor Jon Burtt worked on a number of social circus projects in the Arctic and the sub-Arctic in the far north of Quebec in Nunavik, a semi-autonomous region with Inuit communities dotted around the Hudson Bay, Hudson Strait and Ungava Bay coasts. In this interview, writer and circus director Katie Lavers talks to him about his experiences there, about the programme he was involved in, the Inuit youth involved and their communities, and the effect of the work on him personally.
Shaping an NHS ethics application for research with people with profound and multiple learning disabilities: Creative strategies from a participatory arts practice
Authors: Warwick Melaneia
Published: July 2016

The call for the inclusive participation of adults with intellectual disabilities in research has been taken up by an emerging literature advocating the same opportunities for people with profound and multiple learning disabilities (PMLD). Yet, the barriers to researchers engaging with the demands and particular characteristics of the NHS ethical approval processes are well rehearsed. This can contribute to the marginalization already faced by people with PMLD, with the associated risk that the group remains under-researched. This case study explores current participatory action research utilizing inclusive arts techniques with people with PMLD. It suggests that despite the challenges, engagement with the NHS research ethics processes can be framed not as an isolated form-filling exercise but as a reflective device presenting an ongoing opportunity to gain multiple perspectives on a proposed project. It offers possibilities to collaboratively shape inclusive research design and develop an evolving consent process. It identifies the creative strategies that have contributed to successful ethical approvals and the subsequent participation of people with PMLD in cultural activities.
In this issue - Benefits and disbenefits of computerised medical records (CMR): clinical, patient-centred, implementation and sociotechnical factors
Authors: De Lusignan Simon
Published: July 2016

None
Commentary: A lack of a comparator group makes it hard to be sure whether computerised medical record system implementation achieved a better or worse outcome
Authors: De Lusignan Simon , Williams John , Hinton William , Munro Neil
Published: July 2016

None
Physical Activity in Ankylosing Spondylitis: evaluation and analysis of an eHealth tool
Authors: Tyrrell Jess Shelagh , Redshaw Clare Helen
Published: July 2016

Background Ankylosing spondylitis (AS) is a chronic inflammatory condition characterised by spinal arthritis and exercise is often recommended to reduce the symptoms and improve mobility. However, very little evidence exists for the value of exercise in AS.Objectives Firstly, this pilot study aimed to evaluate an eHealth tool, the AS Observer, specifically designed to monitor symptoms, quality of life and physical activity in AS, in terms of patient experience and suitability in generating data for epidemiological studies. Secondly, it also investigated the collected data to determine if physical activity benefited individuals with AS.Methods The AS Observer was designed to enable weekly monitoring of AS symptoms and exercise using a web based platform. Participants with AS (n = 223) were recruited to use the AS observer. They provided baseline data and completed online weekly data entry for 12 weeks (e.g. Bath Ankylosing Spondylitis Activity Index (BASDAI), howRu, International Physical Activity Questionnaire (IPAQ)). Panel data analysis with fixed effects models investigated associations between variables. Activity type data and exit questionnaires were subjected to qualitative thematic analysis.Results In general, the AS Observer was well received and considered useful by participants, with 66% providing a positive response. The collected data suggested that IPAQ is inversely associated with total BASDAI, stiffness, tenderness and pain, but not fatigue. Stratified analysis demonstrated differential associations between BASDAI, IPAQ and howRU based on sex, HLA-B27 status and disease duration. Approximately half of the participants frequently did therapy and three-quarters undertook at least some vigorous activity ranging from formal exercise to recreation and (house) work. Despite some technical challenges, tool evaluation suggested that the AS Observer was a useful self-monitoring tool for participants.Conclusions This pilot study demonstrated that increased exercise intensity and duration were associated with an improved BASDAI symptom score in a cohort of participants with AS. Furthermore, it provided further evidence of the value of using eHealth tools for clinical purposes and data collection for research, inclusive of the development of treatment pathways and disease management strategies.
Root resorption after dental trauma in permanent molar: a 5-year follow-up
Authors: Dadalti Manoela Teixeira de Sant'Anna , Soares Fabíola Orgima  Barbosa , Gusman Heloísa Carla Dell Santo , Risso Patrícia de Andrade
Published: July 2016

Introduction: There is low incidence of trauma in posterior teeth, and their complications are rarely reported in the literature. This report describes a case of internal root resorption with communication with the periodontal area as a result of traumatic dental injury of a permanent molar tooth. Case Report: The treatment consisted of chemo-mechanical preparation and the use of calcium hydroxide as intracanal medication, followed by filling and sealing of the resorption area with mineral trioxide aggregate. Results: After 5 years of follow-up, the tooth was in function, without signs or symptoms and the resorption area was repaired. Conclusion: We emphasize the importance of follow-up in cases of dental trauma, even in cases of low severity, such as subluxative injury, in order to predict possible sequelae in advance. The correct approach to treatment of the resorption area and sealing with mineral trioxide aggregate ensured the successful outcome of the case.KeywordsMolar; Permanent dentition; Tooth injuries; Root resorption.
Evaluation of Salivary and Serum Alpha Amylase Level in Dental Caries of Adolescence
Authors: Ahmadi- Motamayel Fatemeh , Goodarzi Mohammad Taghi , Jamshidi Zohreh , Mahdavinezhad Ali , Rafieian Nasrin
Published: July 2016

Objective: Some previous studies suggested a significant relationship between alpha- amylase, and caries formation. This study was implemented in order to investigate the interrelation between level of salivary and serum alpha- amylase and dental caries. Material and Methods: In this cross-sectional investigation, un-stimulated whole saliva  and serum sample was collected from 118 high school students  who were divided to four groups: Caries free female (N= 28), caries active females (N=35), caries free males(N= 28) and caries active males(N= 27). Mean levels of salivary and serum alpha-amylase was assayed by spectrophotometric method to assay enzyme kinetics. Data were analyzed using student’s t-test and chi-square test. Results: The results of this study demonstrated  that salivary and Serum alpha- amylase were  significantly   higher in caries active group as compared to carries free group(P = 0.002, P= 0.001 respectively). In addition in male groups the mean salivary and serum alpha -amylase was significantly higher in caries active as compared to caries free (P = 0.002, P = 0.02 respectively) and in   female Groups the mean serum   alpha- amylase was statistically significant higher in caries active as compared to caries free (P = 0.01). Conclusion: The results of this study demonstrated significant association between salivary and serum alpha- amylase in adolescence with dental caries. More research should be done to demonstrate real relation between   alpha amylase and   dental caries.KeywordsAlpha–amylase; Dental caries; Saliva; Serum.
Aspects affecting the choice for scientific journal publishing
Authors: Figueiredo Livia Mara Alves , Palma Ana Luiza do Rosário , Araujo Cássia Fernandes , Pedroso Juliana de Fátima , Jardini Maria Aparecida Neves , Rode Sigmar de Mello
Published: July 2016

Objective: This study aimed to evaluate the social and academic aspects and factors related to scientific journal that influence and motivate the authors to choose the journal to publish their academic work. Material and Methods: The study was conducted with professors and graduate students of the Institute of Science and Technology of Sao Jose dos Campos, UNESP. Participants responded to an online questionnaire, sent via email, and the data were tabulated and analyzed. Result: The Thomson Reuters impact factor, followed by Qualis CAPES Index were considered of greater importance at the moment of choosing the journal for 56% of respondents. All respondents considered peer review relevant and 89% pointed out double-blind review as the most important aspect. Indexing and the journal’s quality were considered the most significant factors by most respondents. 98% of respondents have knowledge on both open access journals and Digital Object Identifier (DOI). Conclusion: The assessed academic community demonstrated good knowledge on the factors inherent to the publication of scientific papers. Impact factor, indexing, and journal’s quality influenced on scientific journal publishing.Keywords: Impact factor; Magazine article; Periodicals.
Incidental findings of bone alterations in temporomandibular joints in cone-beam computed tomography scans adquired for implants planning: the importance of complete field of view analysis
Authors: Lopes Sergio Lucio Pereira de Castro , Moraes Mari Eli Leonelli , Manhães Júnior Luiz Roberto Coutinho , De Assis Afonso Celso Souza , Giosa Danielle Tallia , Urbano Daniel Silveira
Published: July 2016

Objective: to evaluate the frequency of bone alterations in temporomandibular joints (TMJ) in of cone beam computed tomography (CBCT) images, with dental implats planning purpose. Material and Methods: 148 cone beam exames were selected from the file of the Radiology Clinic ICT UNESP. All the images were performed by Next Generation i-CAT (Imaging Sciences Ltda, Hatfield, PA, USA) scanner, using voxel of 0.20/0.25 mm and FOV of 16.0 x 13.0 cm for dental implants planning. All the images should show both (rigth and left) TMJ condyle. The TMJ condyle were reformated using TMJ protocol, with parassagital slices, perpendicular to the long axis of TMJ condyle, in order to study presence of the following bone alterations: osteophytes, erosion, flatenning, bone sclerosis and cortical thinning.  Results: The results showed that 63.51% of the sample belonged to female and 36.49% to male. In addition, it was noted that the most frequent bone alterations in condyle were osteophytes (56.75%) and flatening (55.4%). The erosion was the alteration with lower frequency (0,67%). The statistic test of Mcnemar showed that there was relationship between flatening and erosion, flatening and bone sclerosis, flatening and cortical thinning, erosion and osteophytes, bone sclerosis and cortical thinning (p<0.0001),  in both sides. There was no relationship between flatening and osteophytes, erosion and bone sclerosis, erosion and cortical thinning (p>0.01). Conclusion: the hight frequency of bone alterations findings in TMJ condyle was an indicator of the importance of the analysis of all the structures present in the CBCT FOV, regardless its indication.
CVD and diamond tips: can then influence the bond strength of a total-etch adhesive to dentin?
Authors: Rocha Schirlei de Carvalho , Barcellos Daphne Camara , Pucci César Rogério , Pagani Clovis , Lima Dimas Renó de
Published: July 2016

Data (MPa) were analyzed by two-way ANOVA (Surface treatment X Etching time) and Tukey's test (5%). Results and conclusions: Surface treatment with CVD tips (27.70 ± 4.04a) produced significantly higher bond strength values compared to diamond tips (23.96 ± 5.83b), and 5 second etching time on dentin produced similar bond strength values when compared to 10 and 15 second etching times. Objectives: Evaluate the microtensile bond strength of a total-etch adhesive to dentin, using a CVD tip and a diamond tip to use in dentin preparation and varying the etching time. Material and method: The dentin from the buccal face of sixty bovine teeth was exposed and prepared using two different methods (n=30): Group 1 (DT) – a diamond tip on a high-speed handpiece; and Group 2 (CVD) – a CVD tip on an ultrasonic handpiece. Each group used 37% phosphoric acid and was divided into three subgroups, according to the etching time (n=10): Subgroup 5 - 5 seconds; Subgroup 10 - 10 seconds; and Subgroup 15 - 15 seconds. The teeth were restored with Single Bond adhesive and the composite resin Herculite Classic. The specimens were subjected to thermomechanical wear (mechanical cycling/100.000 cycles, thermal cycling/1.000 cycles). Stick-like specimens were obtained and submitted to a microtensile test in a universal testing machine.
Who will treat our aging population?
Authors: Ettinger Ronald L.
Published: July 2016

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Remuneração docente: Desafiospara o monitoramento da valorização dos professores brasileiros no contexto da meta 17 do Plano Nacional de Educação
Authors: Jacomini Márcia , Alves Thiago , Camargo Rubens Barbosa de
Published: July 2016

Este artigo visa propor estratégias metodológicas para a verificação e monitoramento do cumprimento da meta 17 do Plano Nacional de Educação (PNE) 2014/2024. O plano estabelece que os professores da rede pública de educação básica no Brasil devem ter rendimento médio equiparado aos dos demais profissionais com escolaridade equivalente até 2020. Inicialmente, foi realizada uma breve revisão de estudos sobre remuneração docente e uma abordagem com dados da comparação entre os salários de professores e demais profissionais em países membros da OCDE. Os resultados foram gerados a partir de dados da Pesquisa Nacional por Amostra de Domicílio (PNAD) de 2013, fonte indicada pelo legislador. Na fórmula de cálculo proposta foram indicados parâmetros para seleção de dados e tratamento para as principais variáveis intervenientes da remuneração, tais como: condição de ocupação, tipo de ocupação (segundo a classificação brasileira de ocupações), nível de formação, jornada de trabalho semanal e setor de trabalho. Verificou-se que o salário médio dos professores da educação básica com formação em nível superior e jornada semanal de 40 horas é de R$ 2.613 e equivale a 61,2% dos rendimentos dos demais profissionais (R$ 4.273). Há grande desigualdade entres os estados brasileiros em relação à meta e o cumprimento da meta 17 vai exigir esforços fiscais dos governos subnacionais e da União. A análise indicou que é preciso cautela nas conclusões sobre a meta 17 a partir da PNAD, uma vez que o levantamento amostral não é delineado para captar as características e especificidades do trabalho da população docente.
Optimizing a Menu of Multiformat Subscription Plans for Ad-Supported Media Platforms
Authors: Kanuri Vamsi K. , Mantrala Murali K. , Thorson Esther
Published: July 2016

Media content distribution has changed extensively in the past decade. Content that was once distributed through traditional formats such as television, radio, and print is now available through contemporary digital formats such as smartphone and tablet apps, with many possible versions (e.g., presence or absence of ads). Consequently, many media firms that face heterogeneous markets of consumers with varying content consumption preferences are now offering “menus” of multiformat and multiversion subscription bundles for their customers to choose from. Yet, little systematic model-based guidance exists for configuring and pricing menu options. Moreover, most media firms are audience-building platforms that serve at least two distinct customer groups (content consumers and advertisers) with interrelated demands. Therefore, constructing a menu of content subscription bundles that maximizes total profit from both consumers and advertisers is a formidable challenge. This research proposes a theory-driven implementable model-based approach that can aid media platforms in addressing this challenge. The proposed approach is then demonstrated for a U.S. newspaper, and insights into profit-maximizing menus under various business model and format strategies are provided.
(When) are We Dynamically Optimal? A Psychological Field Guide for Marketing Modelers
Authors: Meyer Robert J. , Hutchinson J. Wesley
Published: July 2016

A common assumption made in structural approaches to empirical strategy research in marketing is that firms and consumers satisfy the assumptions of dynamic optimality when making decisions. When faced with problems of how best to allocate resources, firms are assumed consider the future consequences of different strategic options and, in each point in time, choose the option that maximizes long-term utility. The validity of such assumptions, however, is often called into question by behavioral researchers who point to work in psychology that finds that assumptions of optimality are frequently violated in experimental settings. If this is indeed the case, it would lend support to approaches that argue that markets have inefficiencies that can be discovered and exploited by simpler, largely correlational, methods. In this article, the authors attempt to reconcile these contrasting views by proposing a framework for assessing when assumptions of dynamic optimality are likely to be good ones and when they are likely to be untenable in empirical analysis.
An Abnormally Abnormal Intangible: Stock Returns on Customer Satisfaction
Authors: Fornell Claes , Morgeson Forrest V. , Hult G. Tomas M.
Published: July 2016

Sorescu and Sorescu (2016) and Bharadwaj and Mitra (2016) have made a number of insightful observations and suggestions for future research regarding stock returns on customer satisfaction. They have also provided a series of assessments of a study by Fornell, Morgeson, and Hult (2016) that focus on abnormal returns on customer satisfaction. Building on the original study, as well as the two commentaries and previous research, the study's authors argue that the published empirical evidence is quite consistent in favor of abnormal returns on customer satisfaction. These findings are also supported by the new analysis of Sorescu and Sorescu, who make several important contributions, not only regarding the persistence of abnormal returns over and beyond the technology sector but also with respect to the critical importance of industry classification in the context of customer satisfaction—something that definitely calls for more research attention. In fact, there are many avenues for future research on the economic and financial impact of customer satisfaction, as laid out in the commentaries, the authors’ original article, and this response.
Sounds Big: The Effects of Acoustic Pitch on Product Perceptions
Authors: Lowe Michael L. , Haws Kelly L.
Published: July 2016

There is meaning in sound that transcends language. Structural differences in the sound of a spokesperson's voice or a piece of background music can influence a consumer's perception of product attributes through cross-modal inference. This article examines how differences in acoustic pitch in marketing communications influence consumer's perceptions of product size. Through six studies, the authors find that when associated with a product, lower pitch in voice or music leads consumers to infer a larger product size. Furthermore, evidence shows that this pitch–size effect occurs through a process of visual mental imagery, which can be facilitated through stronger visualization cues delivered via auditory channels and reduced when size perceptions are assessed directly in the presence of visual product information. The cross-modal effects between auditory stimuli and physical products represent an unexplored influence on consumer perception and behavior with important managerial and theoretical implications.
Influencing Acquisition Performance in High-Technology Industries: The Role of Innovation and Relational Overlap
Authors: Saboo Alok R. , Sharma Amalesh , Chakravarty Anindita , Kumar V.
Published: July 2016

Acquisition is an important activity that enables firms to adapt their resource configurations. Acquisition literature has focused only on the levels of innovation or relational resources, the primary dimensions of organizational resource bases. The authors argue that in addition to the levels, the degree of overlap between the acquiring and target firms, in terms of innovation and relational resources, should influence acquisitions. Furthermore, they argue for the importance of the quality of the target's resources along with factors influencing the acquirer's absorptive capacity (e.g., the chief executive officer's [CEO's] functional background and the acquiring firm's marketing intensity and acquisition experience) as contingencies. Using 319 biopharmaceutical acquisitions and a random-effect regression model that accounts for unobserved heterogeneity and the endogeneity of relational and innovation overlap, the authors find that innovation overlap has a positive effect, whereas relational overlap has a negative effect, on acquisition outcomes. Furthermore, the acquirer CEO's throughput background and acquisition experience negatively moderate, whereas the target's innovation resource quality and the acquirer's marketing intensity positively moderate, the influence of innovation overlap. The target's relational resource quality and the acquirer CEO's throughput background positively moderate the influence of relational overlap.
Membrane trafficking and proteolytic activity of γ-secretase in Alzheimer’s disease
Authors: Kanatsu Kunihiko , Tomita Taisuke
Published: July 2016

γ-Secretase is an intramembrane-cleaving protease that generates various forms of amyloid-β peptides (Aβ) that accumulate in the brains of Alzheimer’s disease (AD) patients. The intracellular trafficking and subcellular localization of γ-secretase are linked to both qualitative and quantitative changes in Aβ production. However, the precise intracellular localization of γ-secretase as well as its detailed regulatory mechanisms have remained elusive. Recent genetic studies on AD provide ample evidence that alteration of the subcellular localization of γ-secretase contributes to the pathogenesis of AD. Here we review our current understanding of the intracellular membrane trafficking of γ-secretase, the association between its localization and proteolytic activity, and the possibility of γ-secretase as a therapeutic target against AD.