bluuebunny/crossref_metadata_2025 huggingface dataset:
The Role of Distance Echocardiography Delivery in Patient’s Medical Evacuation Routing
Authors:   I.P. Pavlov First St. Petersburg State Medical University of the Ministry of Healthcare of Russia, St. Petersburg, Russian Federation, Teplov V.M. , Arkhangelskiy N.D. ,   I.P. Pavlov First St. Petersburg State Medical University of the Ministry of Healthcare of Russia, St. Petersburg, Russian Federation, Prasol D.M. ,   I.P. Pavlov First St. Petersburg State Medical University of the Ministry of Healthcare of Russia, St. Petersburg, Russian Federation, Tsebrovskaya E.A. ,   I.P. Pavlov First St. Petersburg State Medical University of the Ministry of Healthcare of Russia, St. Petersburg, Russian Federation, Kolomoytsev V.V. ,   I.P. Pavlov First St. Petersburg State Medical University of the Ministry of Healthcare of Russia, St. Petersburg, Russian Federation, Burykina V.V. ,   I.P. Pavlov First St. Petersburg State Medical University of the Ministry of Healthcare of Russia, St. Petersburg, Russian Federation, Ikhaev A.B. ,   Republican Ambulance Station, Groznyy, Russian Federation, Moskvina S.S. ,   The Ministry of Healthcare of Ivanovo Region, Ivanovo, Russian Federation, Bagnenko S.F. ,   I.P. Pavlov First St. Petersburg State Medical University of the Ministry of Healthcare of Russia, St. Petersburg, Russian Federation
Published: April 2023

Summary. Investigation purpose – to research in the subjects of the Russian Federation (subjects) an impact of introduction of distance echocardiography (ECG) delivery on ambulance crew decision-making on patient hospitalization to profiled hospitals. Materials and methods of the investigation. Investigation materials have been got from 37 subjects. During the investigation a data which characterize work of ambulance crew medical specialists a year before and a year after an introduction of distance ECG delivery for ambulance crews in the subject were compared. Investigation results and their analysis. A usage of ECG distance delivery and analysis technologies provides an increase of number of hospitalizations to profiled medical treatment organizations of patients with acute coronary syndrome which allow to provide necessary treatment measures in stationary conditions promptly.
PENGEMBANGAN WISATA JURANG PENGANTIN DI DESA RABA KECAMATAN WAWO KABUPATEN BIMA
Authors: Munandar Aris , Nurulrahmatia Nafisah , Nurhayati Nurhayati , Huda Nurul
Published: April 2023

This service aims to further introduce alternative tourist attractions in Raba Village, Wawo District, Bima Regency. Besides that, another goal of this service is to be able to increase the village's original income and provide jobs for the local village community. The methods used in this service activity are: socialization of the program, analysis of the attractiveness of tourist objects, environmental conditions and ease of access to tourist attractions, assistance and strengthening of human resources, assistance for institutional strengthening of tourism village community groups, assistance for participatory planning and development of tourist villages, and training and entrepreneurship assistance and making souvenirs to be sold at tourist sites. The result of the dedication is the formation of a natural tourist location "Jurang Pengantin" which will become a tourist destination for local and foreign tourists from Wawo District and the formation of groups of young people who are aware of tourism and have an entrepreneurial spirit.
A Research Article Assessing Social Media Activity Between 2016 and 2018 Relating to the Impact of Metastases in Prostate Cancer on Patients and Caregivers
Authors: Eade Damian , Norman Bobbie , Harris Jack , Harris Laura
Published: April 2023

About 15% of all cancer diagnoses in western Europe are for prostate cancer, and many cancer patients, caregivers, and healthcare professionals communicate over social media to discuss disease, treatments, side effects, concerns, and support. Social media listening can help identify unmet needs and fill gaps in patient treatment pathways. The authors wanted to understand the topics discussed, emotional tonality and sentiment of conversations, and specific behaviours exhibited. For this study, relevant mentions of prostate cancer were harvested using approved search syntax with social media listening technology. A representative sample across market datasets was used to uncover in-depth insights regarding emotions, key topics, perception, and behaviours, followed by an analysis of the qualitative aspects of the conversation to highlight emotions and behaviours related to the authors’ research objectives. About a quarter of the conversations were related to metastatic cancer, and non-metastatic cancer. Peaks coincided with social movements, such as ‘Movember’ and World Cancer Day. Most conversations about prostate cancer, whether metastatic or not, were driven by anxiety, fear, and worry. Throughout the patient journey, there was an underlying dread of disease progression, with peaks and troughs in emotion coinciding with diagnosis, metastases, treatment, and treatment failure. Patients often felt that they were left by their physicians to make their own decisions regarding treatment and used social media to communicate with their peers and caregivers to gain information. Via social media, patients shared information about disease status, treatment options, side effects, and quality of life, while offering each other emotional support.
Diagnosis of Multisystem Inflammatory Syndrome in Child (MIS-C) Case Presenting with Acute Dystonia Secondary to Use of Metoclopramide
Authors: Çiçek Muharrem , Kalaycık Şengül Özlem , Akkuş Yasin , Varlı Yusuf Ziya , Topal Neval
Published: April 2023

Metoclopramide is a dopamine antagonist in the central nervous system and an antiemetic agent. It can cause extrapyramidal symptoms side effects such as dystonic reactions characterized by involuntary, sustained or spasmodic contractions of muscle groups, resulting in twisting, repetitive or abnormal postures. In this study, we aimed to report a pediatric patient who presented with acute dystonia due to metoclopramide use and was finally diagnosed with MIS-C.
PEMODELAN IHK DENGAN REGRESI NONPARAMETRIK SPLINE MULTIVARIABEL
Authors: Nisa Azizatun , Makkulau Makkulau , Laome Lilis , Cahyono Edi , Mukhtar Norma
Published: April 2023

Indeks Harga Konsumen (IHK)  merupakan salah satu indikator ekonomi yang dapat memberikan informasi mengenai perkembangan harga barang dan jasa yang dibayar oleh konsumen atau masyarakat, khususnya masyarakat perkotaan sehingga secara umum mempengaruhi rata-rata harga yang tercipta antara produsen dengan konsumen. Karena pola data yang berubah-ubahberdasarkan selang waktu tertentu tidak tepat memakai regresi linear dan menggunakan lebih dari satu variabelprediktor oleh karena itu dibutuhkan suatu penelitian untuk mencari model terbaik sehingga mampu menjelaskan fenomena terkait menggunakan pendekatan yang sesuai dengan pola hubungan data. Salah satu metode yang dapat digunakan adalah Regresi Nonparametrik Spline. Spline merupakan potongan polinomial tersegmen yang memiliki titik perpaduan bersama yang menunjukkan terjadinya perubahan-perubahan perilaku kurva. Tujuan dari penelitian ini adalah untuk mengetahui pemodelan regresi spline multivariabel pada data Indeks Harga Konsumen.Berdasarkan model terbaik dari IHK di Indonesia adalah pada tiga titik knot dengan nilai GCVminimum 14,07 serta R-square (R2) adalah 0.73 yang berarti kemampuan variabel respon dalam menjelaskan variabel terikatnya sebesar 73% sedangkan sisanya dipengaruhi oleh variabel lain diluar penelitian.
SISTEM PENDUKUNG KEPUTUSAN PENERIMA BANTUAN PROGRAM KELUARGA HARAPAN MENGGUNAKAN METODE WEIGHTED PRODUCT (StudiKasus :KelurahanWandoka Utara)
Authors: Agustina Ega , Ransi Natalis , La Surimi La Surimi , Tenriawaru Andi , Saidi La Ode
Published: April 2023

Tujuan dari penelitian ini adalah untuk menghasilkan sebuah sistem pendukung keputusan untuk menentukan keluarga yang layak menerima bantuan program keluarga harapan sesuai dengan persyratan yang diberikan dengan menggunakan metode Weighted Product. Metode Weighted Product menggunakan Teknik perkalian untuk menghubungkan rating atribut, kemudian rating atribut dipangkatkan dengan bobot atribut yang bersangkutan. Terdapat 10 kriteria utama, 4 kriteria khusus program keluarga harapan dan 6 kriteria umum keluarga msikin yang terdaftar pada Data Terpadu Kesejahteraan Sosial dan 45 data uji yang akan di olah dalam melakukan perhitungan. Hasil pengolahan data memberikan nilai bobot pada setiap kriteria dan selanjutnya dilakukan perangkingan untuk mendapatkan penerima bantuan program keluarga harapan. Hasil pengujian sistem menggunakan metode Balck box testing diperoleh sistem yang diciptakan memberikan hasil yang baik, perhitungan nilai akurasi dengan metode ConfusionMatrix, menggunakan 45 data alternatif, diperoleh nilai Accuracy sebesar 75%, Precision sebesar  77% dan Recall sebesar 9%.
ANALISIS SENTIMEN KOMENTAR NETIZEN INSTAGRAM TERHADAP RACISM DI SEPAK BOLA INDONESIA DENGAN METODE NAIVE BAYES
Authors: Ikhsan Yusuf Muhammad , Ransi Natalis , Arman Arman , Tenriawaru Andi , Saidi La Ode , La Surimi La Surimi
Published: April 2023

Penggunaan kalimat racism yang terjadi dalam dunia Sepak bola, dikarenakan sepak bola adalah sarana bentuk olahraga yang sangat digemari diberbagai belahan dunia dan hampir semua ras mengetahui jika sepak bola itu olahraga yang sangat disukai oleh berbagai kalangan dan golongan, hal tersebut membuat peneliti tertarik untuk melakukan penelitian dengan judul “Analisis Sentimen Komentar Netizen Instagram Terhadap Racism Di Sepak Bola Indonesia Dengan Metode Naive Bayes” penelitian ini dilakukan sebagai salah satu bentuk informasi agar melihat tingkat sentiman masyarakat di media sosial Instagram terhadap Racism.

Penelitian ini dengan menggunakan metode Naive Bayes Classifier. Percobaan dilakukan pada 650 data komentar. Enam ratus lima puluh komentar data tersebut dibagi menjadi 2 kategori. Untuk mengetahui pengaruh jumlah data latih terhadap efektifitas Naïve Bayes Classifier maka diambil beberapa kombinasi banyaknya dokumen latih dan dokumen uji. Secara berurutan kombinasi dokumen latih dan uji tersebut antara lain 90:10, 80:20, 70:30.

Dengan menggunakan metode Naive Bayes Classifier didapatkan accuracy hasil klasifikasi berurut sebesar 82%, 77% dan 80%. Berdasarkan hasil pengujian yang telah dilakukan, accuracy tertinggi didapat pada pembagian 90:10 dengan nilai accuracy 82%. Aplikasi ini dapat dikembangkan untuk platform social media lainnya seperti facebook, instagram, path, kaskus, dan lainnya.
ANALISIS INTERVENSI FUNGSI STEP PADA PERAMALAN JUMLAH KUNJUNGAN WISATAWAN
Authors: Ikram Adi Surya Muhammad , Makkulau Makkulau , Abapihi Bahriddin , Ruslan Ruslan , Baharuddin Baharuddin
Published: April 2023

Tujuan penelitian ini adalah mendapatkan bentuk model intervensi fungsi step yang didapat dari pengamatan data jumlah kunjungan wisatawan di Kota Bau-Bau periode Januari 2015- Desember 2020 dan melakukan peramalan jumlah kunjungan wisatawan di Kota Bau-Bau dalam 6 bulan kedepan dengan model intervensi fungsi step. Suatu data deret waktu yang mengandung intervensiZt, dikelompokkan menjadi data sebelum terjadinya intervensi dan data setelah terjadinya intervensi. Data sebelum terjadinya intervensi Nt dimodelkan dengan menggunakan model Auto Regressive Integrated Moving Average (ARIMA). Dari hasil analisis diperoleh adalah model intervensi ARIMA (0,1,1) dengan fungsi step pertama, yaitu b = 0, s = 9, dan r = 1 yang meghasilkan AIC sebesar 1534,98. Model tersebut terpilih sebagai model terbaik karena memenuhi semua uji yang dilakukan, yaitu signifikansi parameter, uji white noise residual, dan normal residual.
Structured dynamics of the cell-cycle at multiple scales
Authors: Hodgkinson Arran , Tursynkozha Aisha , Trucu Dumitru
Published: April 2023

The eukaryotic cell cycle comprises 4 phases (G1, S, G2, and M) and is an essential component of cellular health, allowing the cell to repair damaged DNA prior to division. Facilitating this processes, p53 is activated by DNA-damage and arrests the cell cycle to allow for the repair of this damage, while mutations in the p53 gene frequently occur in cancer. As such, this process occurs on the cell-scale but affects the organism on the cell population-scale. Here, we present two models of cell cycle progression: The first of these is concerned with the cell-scale process of cell cycle progression and the temporal biochemical processes, driven by cyclins and underlying progression from one phase to the next. The second of these models concerns the cell population-scale process of cell-cycle progression and its arrest under the influence of DNA-damage and p53-activation. Both systems take advantage of structural modeling conventions to develop novels methods for describing and exploring cell-cycle dynamics on these two divergent scales. The cell-scale model represents the accumulations of cyclins across an internal cell space and demonstrates that such a formalism gives rise to a biological clock system, with definite periodicity. The cell population-scale model allows for the exploration of interactions between various regulating proteins and the DNA-damage state of the system and quantitatively demonstrates the structural dynamics which allow p53 to regulate the G2- to M-phase transition and to prevent the mitosis of genetically damaged cells. A divergent periodicity and clear distribution of transition times is observed, as compared with the single-cell system. Comparison to a system with a reduced genetic repair rate shows a greater delay in cell cycle progression and an increased accumulation of cell in the G2-phase, as a result of the p53 biochemical feedback mechanism.
Higher education decision making of Australian women with caring responsibilities
Authors: Munro Deborah , Willis Jill , Gibson Andrew , Laundon Melinda
Published: April 2023

It is well established that women bear greater caring responsibilities than men, however little is known about how this care work influences the decision-making processes of female carers who are considering Higher Education (HE). These deliberations occur well before women commit to enrolling and frequently result in carers making decisions to delay or not pursue HE, with consequences for their own careers and the persistence of gender inequalities more broadly. A scoping review of academic literature published since 1980 which followed the PRISMA-ScR process for scoping reviews was conducted to answer the research question “What is the scope of the literature regarding the influence of caregiver responsibilities on Australian women’s tertiary education decision making processes?” Studying the literature in one national context enabled the influences of personal as well as contextual influences to be identified. The results show that very little is known about how women who have caring responsibilities make decisions about whether or not to undertake HE studies. Important issues were identified such as the lack of a clear definition of carer and recognition of this cohort as an equity group. A complex array of personal, cultural and structural factors which may enable women’s HE decisions were identified, including the desire to achieve personal life goals, the encouragement and support of family members and supportive workplaces. However, constraints such as competing time demands, the continuing prevalence of traditional gendered expectations and idealised notions of HE students as unencumbered were also noted. No studies directly addressed decision-making processes, or how the many elements combined to influence female carers prior to enrolment. The paucity of research points to an urgent need for studies which will address the gaps in knowledge. This review points to new directions in research and decision-making theories to encompass the role of context and care in decisions, and provides some advice meanwhile to inform career practitioners, HE providers and career researchers.
Multiple doses of SHR-1222, a sclerostin monoclonal antibody, in postmenopausal women with osteoporosis: A randomized, double-blind, placebo-controlled, dose-escalation phase 1 trial
Authors: Dai Zhijie , Zhu Ronghua , Sheng Zhifeng , Qin Guijun , Luo Xianghang , Qin Qun , Song Chunli , Li Liping , Jin Ping , Yang Guoping , Cheng Yanxiang , Peng Danhong , Zou Chong , Wang Lijuan , Shentu Jianzhong , Zhang Qin , Zhang Zhe , Yan Xiang , Fang Pingfei , Yan Qiangyong , Yang Lingfeng , Fan Xiao , Liu Wei , Wu Bo , Cui Rongrong , Wu Xiyu , Xie Yuting , Shu Chang , Shen Kai , Wei Wenhua , Lu Wei , Chen Hong , Zhou Zhiguang
Published: April 2023

SHR-1222, a novel humanized monoclonal antibody targeting sclerostin, has been shown to induce bone formation and decrease bone resorption at a single dose ranging 50–400 mg in our previous phase 1 trial. This study was a randomized, double-blind, placebo-controlled, dose-escalation phase 1 trial, which further investigated the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and immunogenicity of multiple ascending doses of SHR-1222 in women with postmenopausal osteoporosis (POP). A total of 105 women with POP were enrolled and randomly assigned. Twenty-one received placebo and eighty-four received SHR-1222 sequentially (100 mg QM, n=4; 200 or 300 mg QM, n=20; and 400 or 600 mg Q2M, n=20). The most common adverse events included increased blood parathyroid hormone, increased low-density lipoprotein, increased blood alkaline phosphatase, increased blood cholesterol, back pain, and arthralgia, the majority of which were mild in severity without noticeable safety concerns. Serum SHR-1222 exposure (Cmax,ss and AUC0-tau,ss) increased in a greater than dose-proportional manner. Following multiple doses of SHR-1222, the bone formation markers (terminal propeptide of type I procollagen, bone-specific alkaline phosphatase, and osteocalcin) increased in a dose-dependent manner, whereas the bone resorption marker (β-C-telopeptide) was downregulated. Accordingly, BMD gains in the lumbar spine, total hip, and femoral neck were observed. The maximum BMD increase from baseline at the lumbar spine was detected in the 300 mg QM cohort (14.6% vs. 0.6% in the placebo group on day 169). Six (6/83; 7.2%) subjects developed anti-SHR-1222 antibodies with no discernible effects on PKs, PDs, and safety. Thus, multiple doses of SHR-1222 showed an acceptable safety profile and dose-dependent plasma exposure in women with POP, and could improve their BMD rapidly and prominently by promoting bone formation and inhibiting bone resorption. These findings further support SHR-1222 as a potential alternative agent for the treatment of POP.
Analyses of the bias and uncertainty of SNF decay heat calculations using Polaris and ORIGEN
Authors: Shama Ahmed , Caruso Stefano , Rochman Dimitri
Published: April 2023

The bias and uncertainty of calculated decay heat from spent nuclear fuel (SNF) are essential for code validation. Also, predicting these quantities is crucial for deriving decay heat safety margins, influencing the design and safety of facilities at the back end of the nuclear fuel cycle. This paper aims to analyze the calculated spent nuclear fuel decay heat biases, uncertainties, and correlations. The calculations are based on the Polaris and ORIGEN codes of the SCALE code system. Stochastically propagated uncertainties of inputs and nuclear data into calculated decay heats are compared. Uncertainty propagation using the former code is straightforward. In contrast, the counterpart of ORIGEN necessitated the pre-generation of perturbed nuclear cross-section libraries using TRITON, followed by coincident perturbations in the ORIGEN calculations. The decay heat uncertainties and correlations have shown that the observed validation biases are insignificant for both Polaris and ORIGEN. Also, similarities are noted between the calculated decay heat uncertainties and correlations of both codes. The fuel assembly burnup and cooling time significantly influence uncertainties and correlations, equivalently expressed in both Polaris and ORIGEN models. The analyzed decay heat data are highly correlated, particularly the fuel assemblies having either similar burnup or similar cooling time. The correlations were used in predicting the validation bias using machine learning models (ML). The predictive performance was analyzed for machine learning models weighting highly correlated benchmarks. The application of random forest models has resulted in promising variance reductions and predicted biases significantly similar to the validation ones. The machine learning results were verified using the MOCABA algorithm (a general Monte Carlo-Bayes procedure). The bias predictive performance of the Bayesian approach is examined on the same validation data. The study highlights the potential of neighborhood-based models, using correlations, in predicting the bias of spent nuclear fuel decay heat calculations and identifying influential and highly similar benchmarks.
Clinical efficacy of Yiqi Yangxue formula on knee osteoarthritis and unraveling therapeutic mechanism through plasma metabolites in rats
Authors: Zhao Ting , Wang Shiqi , Liu Wenbin , Shen Jiayan , Dai Youwu , Shi Mingqin , Huang Xiaoyi , Wei Yuanyuan , Li Tao , Zhang Xiaoyu , Xie Zhaohu , Wang Na , Qin Dongdong , Li Zhaofu
Published: April 2023

Objective: To observe the clinical efficacy and safety of Yiqi Yangxue formula (YQYXF) on knee osteoarthritis (KOA), and to explore the underlying therapeutic mechanism of YQYXF through endogenous differential metabolites and their related metabolic pathways.

Methods: A total of 61 KOA patients were recruited and divided into the treatment group (YQYXF, 30 cases) and the control group (celecoxib, Cxb, 31 cases). Effects of these two drugs on joint pain, swelling, erythrocyte sedimentation rate (ESR) and c-reactive protein (CRP) were observed, and their safety and adverse reactions were investigated. In animal experiments, 63 SD rats were randomly divided into normal control (NC) group, sham operation (sham) group, model (KOA) group, Cxb group, as well as low-dose (YL), medium-dose (YM), and high-dose groups of YQYXF (YH). The KOA rat model was established using a modified Hulth method. Ultra-high-performance liquid chromatography/Q Exactive HF-X Hybrid Quadrupole-Orbitrap Mass (UHPLC-QE-MS)-based metabolomics technology was used to analyze the changes of metabolites in plasma samples of rats. Comprehensive (VIP) >1 and t-test p < 0.05 conditions were used to screen the disease biomarkers of KOA, and the underlying mechanisms of YQYXF were explored through metabolic pathway enrichment analysis. The related markers of YQYXF were further verified by ELISA (enzyme-linked immunosorbent assay).

Results: YQYXF can improve joint pain, swelling, range of motion, joint function, Michel Lequesen index of severity for osteoarthritis (ISOA) score, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score, ESR, and CRP. No apparent adverse reactions were reported. In addition, YQYXF can improve cartilage damage in KOA rats, reverse the abnormal changes of 16 different metabolites, and exert an anti-KOA effect mainly through five metabolic pathways. The levels of reactive oxygen species (ROS) and glutathione (GSH) were significantly decreased after the treatment of YQYXF.

Conclusion: YQYXF can significantly improve the clinical symptoms of KOA patients without obvious adverse reactions. It mainly improved KOA through modulating lipid metabolism-related biomarkers, reducing lipid peroxidation and oxidative stress.
Ensemble-based data assimilation for predictable zones and application for non-linear deep-water waves
Authors: Fujimoto Wataru , Ishibashi Kinya
Published: April 2023

The ensemble-based variational method is easier to implement and parallelize than the adjoint method. For circumstances in which observed data are too limited and sparse for oceanographic data assimilation, the surface wave reconstruction by ensemble adjoint-free data assimilation (SWEAD) method was developed in a previous study. SWEAD generates ensembles of search directions from Fourier modes to numerically differentiate the squared error between observed data and a physical model. However, Fourier modes are global bases and could be redundant for a narrow predictable zone confined by a dispersion relationship. To concentrate ensembles on the predictable zone, we propose using singular value decomposition (SVD) of the approximated Jacobian of the squared error. Here, the Jacobian was first approximated by the linear dispersion relationship and successively updated to consider the non-linearity of the physical system. A new criterion for reusing the ensemble was also devised for this new method, increasing the dimension of search directions. A twin experiment was conducted for non-linear deep-water waves, and the optimization efficiency of the new method—SWEAD using SVD (SWEAD-S)—was significantly greater than that of SWEAD. Expansion of the predictable zone caused by the effect of non-linearity on the wave group velocity is thought to be essential for this improvement.
Migration of endothelial cells on the surface of anodized Ni-Ti stent strut
Authors: Wang Zi , Ohtsu Naofumi , Tate Kasumi , Kojima Yukiko , Saifurrahman Hanif , Ohta Makoto
Published: April 2023

Background

Stent is widely regarded as the main treatment for curing cardiovascular diseases such as stenosis. Previous research has revealed that the damage of endothelial cells (EC), i.e., the components of endothelium, during stent implantation, could lead to severe complications, such as restenosis. To prevent restenosis, enhancements have been made to surface biocompatibility to accelerate the stent endothelialization process. Anodization on the Ni-Ti is a simple and efficient surface modification method to improve the biocompatibility of the Ni-Ti stent surfaces by enhancing the surface hydrophilicity, leading to an increase in the EC activities. The EC activity is known to be affected by the blood flow. Flow change by stent structure may result in EC dysfunctions, thereby leading to restenosis. It is thus essential to investigate the EC activities resulting from the anodization on the Ni-Ti surface under flow conditions.

Objective

To study the influence of the endothelialization process on the Ni-Ti stent surface through anodization. The EC attachment and morphology on the anodized stent strut were observed under both with and without the flow conditions.

Method

A parallel plate flow chamber was designed to generate a constant wall shear stress (WSS) to study the flow effect on the EC behavior. The hydrophilicity of the Ni-Ti stent strut surface was enhanced by a TiO2 layer fabricated via anodization. The EC distribution on the surface of the anodized nitinol stent strut was observed after 24 h of static (without flow) and flow exposure (with flow) experiment.

Results

Under the static condition, the EC density on the surface of the anodized Ni-Ti stent strut was higher compared with the control. Under the flow condition, the enhancement of the EC density on the surface of the stent strut with anodization was reduced. The EC demonstrates a long and thin spindle-shaped morphology under the flow condition.

Conclusion

Unlike the static condition, the EC is demonstrating a long and thin morphology in response to the flow under the flow condition. By improving the surface hydrophilicity, the anodization could enhance the EC migration onto the strut surface, and subsequently, accelerate the Ni-Ti stent endothelialization process. The improvement of the surface hydrophilicity is lower under the flow conditions when compared with the static conditions.
Multi-omic single cell sequencing: Overview and opportunities for kidney disease therapeutic development
Authors: Pregizer Steven , Vreven Thom , Mathur Mohit , Robinson Luke N.
Published: April 2023

Single cell sequencing technologies have rapidly advanced in the last decade and are increasingly applied to gain unprecedented insights by deconstructing complex biology to its fundamental unit, the individual cell. First developed for measurement of gene expression, single cell sequencing approaches have evolved to allow simultaneous profiling of multiple additional features, including chromatin accessibility within the nucleus and protein expression at the cell surface. These multi-omic approaches can now further be applied to cells in situ, capturing the spatial context within which their biology occurs. To extract insights from these complex datasets, new computational tools have facilitated the integration of information across different data types and the use of machine learning approaches. Here, we summarize current experimental and computational methods for generation and integration of single cell multi-omic datasets. We focus on opportunities for multi-omic single cell sequencing to augment therapeutic development for kidney disease, including applications for biomarkers, disease stratification and target identification.
GLP-1 enhances hyperpolarization-activated currents of mouse cerebellar Purkinje cell in vitro
Authors: Liu Yang , Cao Li-Xin , Wang Wei-Yao , Piao Yong-Rui , Wang Jun-Ya , Chu Chun-Ping , Bing Yan-Hua , Qiu De-Lai
Published: April 2023

Glucagon-like peptide-1 (GLP-1) is mainly secreted by preglucagonergic neurons in the nucleus tractus solitarius, which plays critical roles in regulation of neuronal activity in the central nervous system through its receptor. In the cerebellar cortex, GLP-1 receptor is abundantly expressed in the molecular layer, Purkinje cell (PC) layer and granular layer, indicating that GLP-1 may modulate the cerebellar neuronal activity. In this study, we investigated the mechanism by which GLP1 modulates mouse cerebellar PC activity in vitro. After blockade of glutamatergic and GABAergic synaptic transmission in PCs, GLP1 increased the spike firing rate accompanied by depolarization of membrane potential and significantly depressed the after-hyperpolarizing potential and outward rectifying current of spike firing discharges via GLP1 receptors. In the presence of TTX and Ba2+, GLP1 significantly enhanced the hyperpolarized membrane potential-evoked instant current, steady current, tail current (I-tail) and hyperpolarization-activated (IH) current. Application of a selective IH channel antagonist, ZD7288, blocked IH and abolished the effect of GLP1 on PC membrane currents. The GLP1 induced enhancement of membrane currents was also abolished by a selective GLP1 receptor antagonist, exendin-9-39, as well as by protein kinase A (PKA) inhibitors, KT5720 and H89. In addition, immunofluorescence detected GLP1 receptor in the mouse cerebellar cortex, mostly in PCs. These results indicated that GLP1 receptor activation enhanced IH channel activity via PKA signaling, resulting in increased excitability of mouse cerebellar PCs in vitro. The present findings indicate that GLP1 plays a critical role in modulating cerebellar function by regulating the spike firing activity of mouse cerebellar PCs.
Impact of deep learning image reconstruction algorithms on CT radiomic features in patients with liver tumors
Authors: Xue Gongbo , Liu Hongyan , Cai Xiaoyi , Zhang Zhen , Zhang Shuai , Liu Ling , Hu Bin , Wang Guohua
Published: April 2023

Objective

To evaluate the impact of deep learning image reconstruction (DLIR) and adaptive statistical iterative reconstruction-Veo (ASIR-V) on abdominal CT radiomic features acquired in portal venous phase in liver tumor patients.

Methods

Sixty patients with liver tumors who underwent contrast-enhanced abdominal CT were retrospectively enrolled. Six groups including filtered back projection (FBP), ASIR-V (30%, 70%) and DLIR at low (DLIR-L), medium (DLIR-M and high (DLIR-H), were reconstructed using portal venous phase data. CT-based radiomic features (first-order, texture and wavelet features) were extracted from 2D and 3D liver tumors, peritumor and liver parenchyma. All features were analyzed for comparison. P < 0.05 indicated statistically different. The consistency of 3D lesion feature extraction was assessed by calculating intraclass correlation coefficient (ICC).

Results

Different reconstruction algorithms influenced most radiomic features. The percentages of first-order, texture and wavelet features without statistical difference among 2D and 3D lesions, peritumor and liver parenchyma for all six groups were 27.78% (5/18), 5.33% (4/75) and 5.56% (1/18), respectively (all p > 0.05), and they decreased while the level of reconstruction strengthened for both ASIR-V and DLIR. Compared with FBP, the features of ASIR-V30% and 70% without statistical difference decreased from 71.31% to 23.95%, and DLIR-L, DLIR-M, and DLIR-H decreased from 31.65% to 27.11% and 23.73%. Among texture features, unaffected features of peritumor were larger than those of lesions and liver parenchyma, and unaffected 3D lesions features were larger than those of 2D lesions. The consistency of 3D lesion first-order features was excellent, with intra- and inter-observer ICCs ranging from 0.891 to 0.999 and 0.880 to 0.998.

Conclusions

Both ASIR-V and DLIR algorithms with different strengths influenced the radiomic features of abdominal CT images in portal venous phase, and the influences aggravated as reconstruction strength increased.
Good personality and social well-being: The roles of orientation to happiness
Authors: Xu Xiaodan , Liu Yang , Jiao Liying , Wang Yongming , Yu Mengke , Lai Yidie , Zhang Yingjun , Xu Yan
Published: April 2023

Introduction

Positive personality traits have been associated with personal well-being in previous research. However, the pathways through which positive personality may affect social well-being remain unclear. The present study hypothesized that the cognitive strategies for achieving well-being (i.e., orientation to happiness) mediate the association between good personality and social well-being in the Chinese culture.

Methods

A survey including the Good Personality Questionnaire, Social Well-being Scales, and Orientations to Happiness was administered to 1,503 Chinese secondary school students and adults.

Results

The results indicated that orientation to meaning mediated the relation between good personality and social well-being, but not orientation to pleasure.

Discussion

This is in line with the normative well-being model and the cognition instrumental model of well-being, which contributes to developing more targeted interventions to promote social well-being in the Chinese cultural.
Cultivating patient-centered care competence through a telemedicine-based course: An explorative study of undergraduate medical students’ self-reflective writing
Authors: Findyartini Ardi , Hanum Chaina , Kusumoningrum Dewi Anggraeni , Putera Azis Muhammad , Werdhani Retno Asti , Safitry Oktavinda , Muktiarti Dina , Soemarko Dewi Sumaryani , Wisnu Wismandari
Published: April 2023

Background

The COVID-19 pandemic has encouraged adaptations of learning methods in clinical clerkship. There have been limited reports on the merits of involving medical students in telemedicine. This study, therefore, aims to investigate students’ reflection on what they learned and identify the challenges and benefits of doctor-patient interaction through their experience in a telemedicine-based course.

Methods

A 4 week telemedicine-based course for medical students to participate in telemonitoring of COVID-19 patients undergoing self-isolation was conducted. This is a qualitative study using an interpretive phenomenology design to investigate students’ self-reflection on their experiences in monitoring COVID-19 patients. Students were asked to reflect on their experience upon completion of the course through 750–1,000 words essays. A thematic analysis which considers units of meaning based on students’ experiences was completed.

Results

Our study identified four main themes gathered from students’ experiences related to the telemedicine-based course: communication and education, professionalism and professional identity formation, system-based practice, and patient-centered care.

Conclusion

The course was part of an integrative effort involving multiple parties to tackle the burden on the nation’s healthcare system during the pandemic. Telemedicine is part of future medical practice which supports the medical curriculum adaptability along with attempts to develop future-proof medical doctors through various clinical learning experiences.
Altruism or self-interest in tomorrow's veterinarians? A metric conjoint experiment and cluster analysis
Authors: Feakes Adele , Lindsay Noel , Palmer Edward , Steffens Paul
Published: April 2023

Introduction

Altruism is considered a trait of veterinary and other health professionals, but the level of altruism in the veterinary profession is unknown. We designed a metric conjoint experiment to reveal other-orientation (an individual's caring concern for the wellbeing of others) and self-interest. We draw on the ‘Theory of Other-Orientation’, which states that individuals' decision-making heuristics can be impacted by their other-orientation independent of their self-interest. In patient-focused contexts, highly other-oriented or altruistic (veterinary) professionals may care too much for others and suffer immediate or cumulative financial and personal costs of such caring. At the same time, other-orientation can enhance job-related attitudes and outcomes, such as job satisfaction.

Methods

In a metric conjoint experiment, Australian final-year veterinary, science, nursing, entrepreneurship, and engineering students rated eight job scenarios with orthogonally arranged high and low levels of three job characteristics (n = 586) to provide observed measures of other-orientation and self-interest.

Results

A two-way MANOVA showed other-orientation or self-interest differed per discipline, but not gender. Veterinary (and engineering) respondents were less other-oriented than nursing respondents. Veterinary (and entrepreneurship) respondents were more self-interested than nursing respondents. K-Means cluster analysis confirmed four distinct profile groupings—altruistic/self-sacrificing, ‘both other-self’, self-interested and selfish—aligning with the discourse in the literature. Human nursing respondents stood out for the most members (50%) in the ‘both other-self’ profile compared to veterinary respondents (28%). Respondents of one of three veterinary schools stood out for the most members (19%) in the altruistic/self-sacrificing group.

Discussion

Our metric conjoint experiment illustrates an alternative to ‘self-report’ items with Likert-scaled responses. Our finding of the ‘both other-self’ group adds to the literature, which considers that other-orientation and self-interest are separate constructs that are difficult to co-exist in individuals. This mix of traits is deemed helpful by organizational psychology scholars, for sustainability and wellbeing, especially for healthcare professionals involved in high-frequency and intense, patient-focused interactions. Our findings highlight the need for more research on the potential role of other-orientation and self-interest in veterinary school admissions processes, the hidden or taught curricula, job-related attitudes and beliefs, and wellbeing and professional sustainability in the veterinary sector.
A Pilot Single-Blinded, Randomized, Controlled Trial Comparing BNT162b2 vs. JNJ-78436735 Vaccine as the Third Dose After Two Doses of BNT162b2 Vaccine in Solid Organ Transplant Recipients
Authors: Natori Yoichiro , Martin Eric , Mattiazzi Adela , Arosemena Leopoldo , Ortigosa-Goggins Mariella , Shobana Sivan , Roth David , Kupin Warren Lee , Burke George William , Ciancio Gaetano , Morsi Mahmoud , Phancao Anita , Munagala Mrudula R. , Butrous Hoda , Manickavel Suresh , Sinha Neeraj , Sota Katherine , Pallikkuth Suresh , Bini Julia , Simkins Jacques , Anjan Shweta , Vianna Rodrigo M. , Guerra Giselle
Published: April 2023

Solid Organ Transplant (SOT) recipients are at significant higher risk for COVID-19 and due to immunosuppressive medication, the immunogenicity after vaccination is suboptimal. In the previous studies, booster method showed significant benefit in this population. In the current study, we compared using a mix-and-match method vs. same vaccine as a third dose in SOT recipients. This was a patient-blinded, single center, randomized controlled trial comparing BNT162b2 vs. JNJ-78436735 vaccine as the third dose after two doses of BNT162b2 vaccine. We included adult SOT recipients with functional graft who had received two doses of BNT162b2 vaccine. Participants were randomly assigned to receive either BNT162b2 or JNJ-78436735 in one-to-one ratio. Primary outcome was SARS-CoV-2 IgG positivity at 1 month after the third dose. Sixty SOT recipients, including 36 kidney, 12 liver, 2 lung, 3 heart, and 5 combined transplants, were enrolled, and 57 recipients were analyzed per protocol. There were no statistically significant differences between the two vaccine protocols for IgG positivity (83.3% vs. 85.2% for BNT162b2 and JNJ-78436735, respectively, p = 0.85, Odds Ratio 0.95, 95% Confidence Interval 0.23–4.00). Comparison of the geometric mean titer demonstrated a higher trend with BNT162b2 (p = 0.09). In this pilot randomized controlled trial comparing mix and match method vs. uniform vaccination in SOT recipients, both vaccines were safely used. Since this was a small sample sized study, there was no statistically significant difference in immunogenicity; though, the mix and match method showed relatively lower geometric mean titer, as compared to uniform vaccine. Further studies need to be conducted to determine duration of this immunogenicity.

Clinical Trial Registration: https://clinicaltrials.gov/ct2/show/NCT05047640?term=20210641&draw=2&rank=1, identifier 20210641.
You Look at Me Looking at You Looking at Me
Authors: Jurack Brigitte
Published: April 2023

Living and working for a month at the Sanskriti Foundation in Delhi, the artist’s life was watched and observed by a group of resident monkeys. This paper is based on notes begun during that studio residency and represents the critical reflections emerging alongside the hands-on sculptural practice. It is illustrated with close-up photographs of the artist’s sculpture that asks how encounters with fabled animals in densely populated 21st century urban areas can alter our understanding of the gaze as an inter-species gaze. The sculpture and paper begin to ask broader questions, including how can sculpture provide a different, and perhaps more tacit and empathetic, encounter with the other to enable a physical, mental or spiritual experience of cultural entanglement between the various onlookers? In how far is modelling the other’s gaze a form of embodiment and mimicry? Do the fast-changing camera angles and soundtracks of natural history programmes hinder an empathic inter-species encounter? Or, does the slow animation of the artist’s sculpted surface heighten a sense of being alongside equally curious, cunning and adaptable others such as crows, foxes and monkeys?
Oxidation Kinetics of Neat Methyl Oleate and as a Blend with Solketal
Authors: Türck Julian , Schmitt Fabian , Anthofer Lukas , Lichtinger Anne , Türck Ralf , Ruck Wolfgang , Krahl Jürgen
Published: April 2023

The complexity of biodiesel aging has shown that the mechanism needs further research. The rate of aging product formation and associated interactions can help improve fuel quality. Since biodiesel is a multicomponent system and constant changes occur in the chemical environment, which interactions yield which products must be shown in more detail. Particularly under observation was the correlation between peroxides and epoxides. In addition, it is critical that the influence and interactions of new drop-in fuel candidates be investigated. In this work, the kinetics of the formation of aging products of methyl oleate (C18:1) are studied. The aim was to reduce the complexity in order to be able to make more precise and detailed statements about the mechanism. Ketones, acids, peroxide, and epoxide values were recorded. A distinction is made between pure methyl oleate and mixtures with 3 wt% isopropylidene glycerine (solketal). After solketal decomposed in the blends, the aging process showed changes. The influence of solketal resulted in a higher number of acids and epoxides over time. It implied that peroxides are not necessarily the precursor of epoxides. In summary, correlation and solketal’s influence showed that a sequence of aging products could be detected.
Does Personality, Trait Emotion Regulation, and Trait Attentional Control Contribute toward the Experience and Impact of an Alcohol Hangover?
Authors: Hudson Felicity , Gunn Craig
Published: April 2023

Mixed results have been reported for the relationship between personality and hangover, but recent findings have indicated that regulatory and attentional control processes may relate to hangover severity and the impact of a hangover on completing daily activities. This study aimed to explore how these factors relate to hangover severity, hangover impact, and to unhealthy alcohol use. In total, 108 participants completed a survey, rating the severity and impact of their last-experienced hangover and completing measures of the above factors. Separate multiple linear regressions were conducted to analyse each outcome (severity, impact, unhealthy drinking). For severity, the overall regression was significant (Adj. R2 = 0.46, p < 0.001), with the attentional control factor ‘Focusing’ (B = −0.096, p = 0.011), and personality factor ‘Agreeableness’ (B = 0.072, p = 0.005) predicting severity. For impact, the overall regression was significant (Adj. R2 = 0.41, p < 0.001) with the attentional control factor ‘Shifting’ (B = −0.252, p = 0.021), personality factors ‘Extraversion’ (B = 0.225, p = 0.009) and ‘Agreeableness’ (B = −0.156, p = 0.042), and hangover severity (B = 1.603, p < 0.001) predicting impact. For unhealthy drinking, the overall regression model was significant (Adj. R2 = 0.45, p < 0.001) with emotion dysregulation factors ‘Awareness’ (B = 0.301, p = 0.044) and ‘Impulse Control’ (B = 0.381, p = 0.011) predicting unhealthy drinking. These findings add to our understanding of the heterogeneity of hangover experience and highlight that attentional control, emotion regulation, and personality play important roles in the experience and impact of a hangover.
Principles of Nutritional Management in Patients with Liver Dysfunction—A Narrative Review
Authors: Elsebaie Essam Mohamed , Abdel-Fattah Alyaa Nasr , Bakr Nagwa Awad , Attalah Kadry Mohamed , Aweas Abdel-Hady Ahmed
Published: April 2023

According to studies, the liver’s ability to perform its physiological functions in the body determines the diet of patients with liver diseases. Malnutrition results from the liver’s inability to metabolize nutrients as a result of chronic liver dysfunctions. Objectives: Reviewing the data about diets and dietary supplements that manage liver dysfunctions nutritionally. Results: Malnutrition is particularly prevalent in cirrhosis patients, according to clinical studies. Because malnutrition has a significant negative impact on morbidity, mortality, and quality of life, it is crucial to evaluate all cirrhosis patients, regardless of etiology or severity. A term of supplemental enteral nutrition may be suggested for patients who do not achieve their nutritional objectives. A detailed nutritional and exercise assessment will enable the development of an individualized treatment plan that includes dietary and exercise plans. The dietary treatment should outline daily calorie targets with a focus on high-quality protein and address any vitamin and micronutrient deficiencies, with a diet high in those nutrients or supplements. Conclusions: While there is evidence to support the use of particular restricted dietary plans and dietary supplements to manage liver diseases, these findings should be regarded as preliminary until they are confirmed in larger randomized controlled clinical trials.