bluuebunny/crossref_metadata_2025 huggingface dataset:
Growth, feed efficiency, liver biomarkers, antioxidants, hematological indices, immune gene expression, and immunomodulatory effect of Mesosphaerum suaveolens leaf extract in grass carp (Ctenopharyngodon idellus) against Aeromonas hydrophila
Authors: Sattanathan Govindharajan , Madesh Muniyappan , Yu Hairui , Padmapriya Swaminathan , cai Demin , Venkatalakshmi Sournamanikam , Rajesh Ramasamy
Published: July 2024

Background The study was to examine the effects of Mesosphaerum suaveolens (MS) leaf extract on growth performance, whole body composition, immunological responses, hematological parameters, digestive enzymes, and antioxidant status in grass carp (Ctenopharyngodon idellus).
Methods A total of 525 grass carp, with an average body weight of 110.0 ± 1.0 g, were utilized in a 70-day feeding experiment. Fish were randomly allocated to one of five groups. Each group had a triplicate tank with 35 fish per tank. Dietary treatment composed of a basal diet was given to the control group (MS0); MS1, MS2, MS3, and MS4 were substituted with 0, 1, 2, 3, and 4 g/kg of the basal diet, respectively. Fish, relative percent survival (RPS) was measured 14 days after Aeromonas hydrophila (1x107 cells/mL) was given to the fish at the end of the feeding trial.
Results Significant enhancements were shown in growth performance indicators and the body's crude lipid and moisture of the grass carp fed increasing levels of MS compared with the control. Serum levels of total triglycerides, total cholesterol, total protein, glucose, globulin, albumin, oxalate transaminase, glutamic pyruvate transaminase, and serum content of red blood cells, hemoglobin, hemocrit, and white blood cells significantly increased, and mean cell hemoglobin and mean cell hemoglobin concentrations significantly decreased in the grass carp fed the MS-supplemented diets. The liver catalase enzyme, total antioxidant capacity, superoxide dismutase, and glutathione peroxidase activities were increased, and liver malondialdehyde was lower in the in the MS groups compared to the control. Dietary MS supplementation improved the respiratory burst, myeloperoxidase, lysozyme, alternative complement, ceruloplasmin, antiprotease, haemagglutination, bacterial agglutination, and total immunoglobulin levels compared with the control. After being exposed to A. hydrophila for seventy days, the grass carp that was given MS extracts showed a better rate of survival than the control group at the end of the experiment; the highest survival rates were seen in the MS3 and MS4. The transcriptional examination of these gene expressions showed that the spleen and head kidney of grass carp 14-day infection had significantly elevated expression levels of major beta 2 microglobulin (β2M), Toll-like receptor 22 (TLR 22), tumor necrosis factor-alpha (TNFα), Lysozyme-C, and Lysozyme-G.
Conclusions Overall, the present research's results suggest that MS extract's growth promotion, immunological responses, hematological parameters, digestive enzymes, and antioxidant status make it an acceptable option for use as a feed additive in grass carp farms.
Salivary Cortisol Levels and Periodontal Condition of Chemical Dependent Patients
Authors: Batista Julia Arruda , Chiba Fernando Yamamoto , Borges Sabrina de Melo , Saliba Tânia Adas , Garbin Cléa Adas Saliba
Published: July 2024

Background: Drug addiction can harm oral health, as the use of illicit substances can reduce salivary flow and the buffering capacity of saliva, facilitating the development of periodontal disease. Salivary cortisol levels can influence oral health, as increased levels of this hormone may be related to a decreased immune response, affecting periodontal tissues. Objective: To evaluate salivary cortisol levels and their relationship with the periodontal condition of chemical dependent patients. Methods: The study was carried out on 60 institutionalized chemical dependent patients. Data on sociodemographic characteristics were collected through interviews and periodontal condition was assessed using the Community Periodontal Index. Analysis of salivary cortisol levels was performed using the ELISA method. Results: Of the 360 mouth sextants, 59 (16.39%) were healthy; 69 (19.17%) had bleeding on probing; 75 (20.83%) had dental calculus; 79 (21.94%) had periodontal pockets; and 78 (21.67%) were excluded. The average number of healthy sextants was 0.98+1.83; of sextants with bleeding on probing was 1.15+1.64; of sextants with dental calculus was 1.25+1.78; of sextants with periodontal pocket was 1.32+1.71; and of excluded sextants it was 1.28+1.91. The concentration of salivary cortisol was significantly higher (p=0.0015) in patients who had at least one sextant with gingival bleeding (89.31+96.06) compared to those who did not have gingival bleeding (23.96+29.09). Conclusion: The patients presented severe damage to their periodontal condition and those with gingival bleeding had a higher concentration of salivary cortisol.
Editorial
Authors: Hewitt Ramírez Nohelia
Published: July 2024

El volumen 15, número 1, de la revista Psychología: Avances de la disciplina, publica 6 artículos de investigadores españoles, argentinos, chilenos, mexicanos y colombianos, cuyas temáticas se encuentran en línea con las áreas de especialidad de la misma, como son la psicología de la salud, la neuropsicología y la psicología clínica.
Análisis comparativo entre regiones del mundo relacionado con el consumo de sustancias psicoactivas en las últimas tres décadas
Authors: Restrepo Betancur Luis Fernando
Published: July 2024

El consumo de sustancias psicoactivas (SPA) trae efectos de adicción que modifican el pensamiento, la mente y el espíritu del adicto, no solo está generando un riesgo latente que afecta la salud de las personas, también trae consecuencias negativas para la sociedad misma, como mayor inversión económica en salud, presencia de habitantes de calle, aumento de delincuencia, entre otros aspectos. El objetivo del presente estudio consistió en evaluar las estadísticas relacionadas con el consumo de sustancias psicoactivas a nivel mundial en las últimas tres décadas. Para el análisis de la información se utilizó la técnica multivariada de la varianza MANOVA con contraste canónica ortogonal, se empleó el paquete estadístico SAS University en el proceso de la información. Como resultado destacado, se encontró divergencia estadística entre regiones, donde Norteamérica ocupa el primer lugar seguido de Asia y Oceanía. El mayor número de muertes por trastornos relacionados por el consumo de SPA se da en personas menores a los 49 años. El acelerado incremento y abuso en el consumo de SPA está generando altos índices de morbilidad y mortalidad a nivel global. Es una prioridad actuar con urgencia desde todos los frentes, profesionales de la salud, líderes políticos y comunitarios, entes educativos y núcleo familiar, para controlar esta problemática y tratar de disminuir el consumo y abuso de SPA.
RUH SAĞLIĞININ MEKÂNSAL YANSIMASI: BAKIRKÖY RUH VE SİNİR HASTALIKLARI HASTANESİ ÖRNEĞİ ÜZERİNE SOSYOLOJİK BİR İNCELEME
Authors: Demir Ali Eren
Published: July 2024

Bu çalışma, ruh sağlığı mekânlarının toplumsal ve mekânsal boyutlarını Bakırköy Ruh Sağlığı ve Sinir Hastalıkları Eğitim ve Araştırma Hastanesi örneğinde ele almaktadır. Araştırmanın amacı, hastane mekânının sağlık personelinin deneyimleri ve perspektifleri aracılığıyla nasıl bir yaşam alanına dönüşmekte ve toplumsal bir anlam taşımakta olduğunu anlamaktır. Araştırma, fenomenoloji deseni kullanılarak gerçekleştirilmiştir. Örneklemin toplamda 10 kişiden oluştuğu belirtilmiştir: 5 hemşire, 1 tıbbi sekreter, 1 personel, 2 psikiyatrist ve 1 sosyal hizmet uzmanı. Örneklemin seçimi kartopu örnekleme yöntemiyle yapılmıştır. Veri toplama aracı olarak yarı yapılandırılmış görüşme formu kullanılmış ve bu form araştırmacılar tarafından geliştirilmiştir. Görüşmelerin içeriği ve detayları MAXQDA 2018 yazılımı kullanılarak içerik analizi yöntemiyle incelenmiştir. Elde edilen temel sonuçlar arasında, ruh sağlığı mekânlarının karmaşık bir öykü yumağı olduğu, ruh sağlığıyla mekânların sürekli etkileşim hâlinde olduğu ve hastanelerde sosyolojik bir bakış açısının önemli olduğu vurgulanmıştır.
SOSYAL ÇALIŞMACILARDA MAHREMİYETE DUYARLILIK ÖLÇEĞİNİN GELİŞTİRİLMESİ
Authors: Apak Emrah , Uysal Muhterem , Erdem Metin
Published: July 2024

Sosyal hizmet mesleğinde, sosyal çalışmacılar ile müracaatçılar arasında güven ilişkisinin kurularak, nitelikli çalışmaların yapılmasının temel unsurlarından birisi mahremiyet ilkesine duyarlı olmaktır. Bu çalışmanın amacı Sosyal Çalışmacılarda Mahremiyete Duyarlılık Ölçeğini (SÇMDÖ) geliştirmektir. Bu kapsamda geçerlik ve güvenirlik analizleri yapılmıştır. Araştırma iki örneklemden oluşmaktadır. Birinci örneklem açıklayıcı faktör analizi için (AFA) 129 (81 Kadın, 48 Erkek) sosyal çalışmacıdan oluşmaktadır. İkinci örneklemde ise doğrulayıcı faktör analizi için (DFA) 106 (65 Kadın, 41 Erkek) sosyal çalışmacıya ulaşılmıştır. AFA sonucunda tek faktörlü 8 maddelik ölçek oluşturulmuştur. DFA sonucunda (χ2/df 1.31, RMSEA 0.05, SRMR 0.01, TLI 0.97, CFI 0.98, GFI 0.99 ve IFI 0.98) geçerli sonuçlar elde edilmiştir. Ayrıca, iç tutarlılık katsayının ve ölçüt geçerliliği korelasyonunun yüksek olduğu görülmektedir. Ölçeğin güvenirliği için cronbach’s alfa katsayısı ve benzer çalışmanın koalisyonuna bakılmıştır. Sonuç olarak sosyal çalışmacılarda mahremiyete duyarlılık ölçeği, sosyal çalışmacılarda mahremiyeti ölçmede kullanmada geçerli bir ölçektir.
Freedom and Unfreedom in the Russian Empire in the Debate between Chicherin and Rennenkampf at the End of the Nineteenth Century
Authors: Hamburg Gary ,   Claremont McKenna College
Published: July 2024

This article treats the polemic between the conservative-liberal Boris Chicherin and Nikolai Rennnenkampf on the Polish and Jewish questions. Some portions of the exchange appeared in legal, and others in clandestine editions. The initial critical encounter between them in the early 1880s was an abstract debate about the metaphysical grounding of rights. But already at that time, the two opponents raised the fundamental question as to whether Russia’s political future would focus on individual liberty or on the will of state officials and that of the majority in society. The polemic continued in the mid-1890s with Chicherin’s publication of Kurs gosudarstvennoi nauki, in which the conservative-liberal criticized the Church and the national policy of the Empire. The more conservative Rennnenkampf answered with two open letters,in which he castigated Poles for threatening the social equilibrium in the Western provinces of the Empire. Rennenkampf also viewed the Jewish question as “incomparably more complex” than the Polish question. Chicherin responded to Rennenkampf in a short book published abroad. He did not agree with Rennenkampf ’s assertion that the Jewish problem was “more complex” than the Polish question; indeed, Chicherin thought it “much simpler”. By the 1890s, Chicherin had changed his ideas about the Polish question but also about Russia’s readiness for constitutional government. Indeed, he had reached the conclusion that Russia itself was ready for a representative assembly. He was troubled by the Petersburg government’s promotion of Orthodoxy and of Russian language on the Empire’s western periphery. For Chicherin, the encounter with Rennenkampf had the highest possible stakes — the choice between freedom and unfreedom inside Russia itself. Rennenkampf called for unrelenting pressure on Russia’s “enemies”.
Political Departments on Soviet Railways during the Years of War Communism
Authors: Davydov Alexander Yu. ,   Herzen State Pedagogical University of Russia
Published: July 2024

The article examines the activities of the railway political departments in 1919–1920. They were institutions created by the Bolshevik leadership under the People’s Commissariat of Railways to resolve issues in emergency mode. The article aims to analyze the activities of these organizations in establishing their dictate on the railways in the first years of the Soviet power. The study of the work of political departments is relevant in the context of understanding the mechanisms of the political influence of the Soviet state on the society. The article sheds light on the under-researched aspect and introduces not previously used sources into the scholarship. The article provides facts about two stages of the functioning of the organizations in question. During the first stage (March 1919 — January 1920), the attention was focused on their political/educational activities; their impact on the economic/political spheres was minimal. During the second stage (January 1920 — January 1921), when the political departments became a means of the People’s Commissar of Railways, L. D. Trotsky, all the structures of the transport complex of the Russian Soviet Federated Socialist Republic were subordinated to them. The author puts forward a thesis of how the absolute power of the political departments and the People’s Commissariat of Communication Routes of the Soviet Union was extended to the railways and workforce. The author also develops the idea expressed earlier in the scholarship about the transformation of political departments and the suppressed trade union of transport workers into a powerful party-state structure, which, under the leadership of Trotsky, became a key player in the restoration of the country’s economy after the Civil War.
The Role of Armenian Charitable Societies and Educational Centers of Constantinople in Emancipation of Women
Authors: Hambardzumyan Naira V. ,   Institute of Literature after Manuk Abeghian of the National Academy of Sciences of the Republic of Armenia
Published: July 2024

The study focuses on the strategies, activities, characteristics, and interactions of Armenian charitable societies and educational centers established by Armenian women intellectuals in the Ottoman Empire in the second half of the 19th century. The aim of the study is to examine the activities of the establishments founded in the Ottoman Empire, Constantinople in particular, as well as their essential role and purpose in the processes of women’s emancipation. The research shows that these charities helped all the educational centers, in which girls from disadvantaged families studied, with clothes, daily allowance, stationery, and financial means. The aim of the study is to classify those charities and educational centres in terms of their benefits to the nation and ideological basis. It is important and relevant not only as far as interdisciplinarity is concerned, but also from the perspective of analyzing women’s issues in Armenological Studies. The study of the Armenian charitable societies and educational centers established in the Ottoman Empire in the second half of the 19th century reveal not only their functionality, but also their goals, plans, strategies, and ideological foundations in the context of women’s emancipation. In socio-public relations, these organizations not only helped to secure women’s rights and freedoms in education, upbringing, and work but also to liberated them from the unwritten taboos and laws of the patriarchal society.
Humanity Doesn’t Need a Cold War [Rev. on: Shen Zhihua. Economic Vortex: The Beginning of the Cold War Reinterpreted. Hongkong, 2022. 423 p.]
Authors: Sun Yizhi ,   St. Petersburg State University
Published: July 2024

This review focuses on the book by leading Chinese historian Shen Zhihua, Economic Vortex: The Beginning of the Cold War Reinterpreted (Hongkong, 2022). The central question that Shen wants to answer in his work is “Could the Cold War have been avoided?” The professor examines this question through a “new angle” — the economic relationship between the United States and the Soviet Union. Ultimately, Professor Shen concluded that the Cold War was an “accidental product” that could have been avoided. Further political and economic cooperation between U. S. and Soviet Union after World War II was in fact possible. The coexistence of two different ideologies and systems was also possible. The monograph consists of seven chapters. Shen analyzes in detail how the U. S. and the USSR gradually fell into an “economic vortex”, severing all economic relations between them. History — lessons for the future. The current situation in the world, the conflict between the two superpowers, China and U. S., has made the issue of the Cold War particularly relevant. Professor Shen believes that the outbreak of the Cold War in the middle of the last century is a “historical nuisance” for all mankind and contradicted the main course of the history of all mankind — the peaceful way of development. The PRC and the U. S. must not repeat the mistakes made by the American and Soviet leadership in the 20th century, which ended up dragging the entire world into a long and senseless conflict.
Assessing the Improvement of a Sparse Rain Gauge Network in a Landslide Hotspot in Kerala, India—A Multi-Criteria Approach
Authors: Vishnu C. L. , Oommen Thomas , Chatterjee Snehamoy , Rajaneesh A. , Sajin Kumar K. S.
Published: July 2024

A statistically sufficient number of rainfall estimates is necessary to model precipitation-induced landslide hazards accurately. This is particularly important where existing gauges are scanty and widespread, such as in Kerala State of southern India, an area characterized by heavy monsoon rains and thus inherently prone to massive landslides. To identify potential new gauge sites, we evaluated general slope stability, landslide density, and land cover. We optimized locations for installing new rain gauges through a sequential process based on interpolation errors; this was validated by comparing the resulting statistics with a random selection. Based on these procedures, we installed eight new rain gauges. We also used a satellite-gauge algorithm (conditional merging) to assess the effect of rain gauge network expansion for precipitation measurements. The Pearson correlation coefficient indicated statistically significant measurement improvement after the new rain gauge installation. We applied the leave-one-out cross-validation (LOOCV) test to improve rain gauge modeling. We divided the study area into rain gauge influence sections and calculated the root mean square error (RMSE) for each. We found that the optimized expanded rain gauge network locally produced a 20–25 percent reduction of RMSE compared with the original gauge distribution.
Fonogesty – metoda wspomagająca wzrokową percepcję wypowiedzi przez osoby z uszkodzeniami słuchu
Authors: Borowicz Aleksandra
Published: July 2024

W artykule poruszone zostały kwestie wspomagania percepcji wzrokowej osób z uszkodzeniami słuchu i wykorzystania w tym celu metody fonogestów. Omówione zostały korzyści ze stosowania tej metody komunikacyjnej. W kolejnej części zaprezentowano efekty projektu Cued Speech Europa z uwzględnieniem opisu poszczególnych części (publikacji, kursów, ćwiczeń utrwalających). Kolejna część artykułu poświęcona została zaprezentowaniu wyników badań przeprowadzonych wśród uczestników internetowych kursów metody fonogestów. W podsumowaniu Czytelnik dowiaduje się jak wygląda progres metody Cued Speech na świecie.
Psychologiczne i językowe aspekty trudności szkolnych u dzieci z rozpoznaniem dysleksji rozwojowej. Elementy pracy terapeutycznej
Authors: Czarnecka Martyna , Żelazkowska Mariola
Published: July 2024

Niniejsza publikacja koncentruje się na kompleksowym podejściu do problematyki dysleksji rozwojowej u dzieci. Autorzy skupiają się na analizie trudności szkolnych z perspektywy psychopedagogicznej i językowej, podkreślając znaczenie indywidualnego podejścia do każdego przypadku. W artykule przedstawiono wybrane metody pracy terapeutycznej, w tym interwencje pedagogiczne oraz techniki psychoterapeutyczne, które są kluczowe w efektywnym wsparciu dzieci z dysleksją. Autorzy podkreślają, że skuteczna terapia wymaga holistycznego podejścia, uwzględniającego zarówno aspekty edukacyjne, jak i emocjonalne uczniów. Publikacja wnosi istotny wkład w zrozumienie złożoności dysleksji rozwojowej oraz podkreśla znaczenie interdyscyplinarnego podejścia w edukacji i terapii dzieci z tym rozpoznaniem.
Identification of the Anti-ischemia-reperfusion Injury Effect of
Baicalein from Scutellaria Baicalensis Georgi in Liver
Transplantation
Authors: Liu Junyan , Guo Shanshan , Gong Junhua , Cheng Lue , Luo Jiefu , Cheng Mingxiang , Li Shengwei , Gong Jianping , Jia Degong
Published: July 2024

Background:

The complex etiology of Ischemia-Reperfusion Injury (IRI) induced by liver transplantation (LT) and the “one-target-focused” method limit the development of effective therapeutic interventions. We aimed to reveal the specific active ingredients and mechanisms involved in the Chinese herb Scutellaria baicalensis Georgi
(SBG) in alleviating IRI in LT.

Methods:

The active ingredients and potential macromolecular targets of SBG were
screened through related databases. The differentially expressed genes of LT were obtained from GSE151648. The protein-protein interaction network was constructed by the
STRING database, and Cytoscape 3.7.1 was used to construct a compound-target-disease network. GO and KEGG enrichment analyses were performed on the DAVID
database. Finally, the main active components of SBG and the corresponding mechanisms were verified in a donation after circulatory death (DCD) rat LT model.

Results:

Thirty-two active ingredients of SBG and their targets were identified, and a total of 38 intersection targets were obtained. GO function and KEGG pathway enrichment analyses demonstrated that the plasma membrane and its components play an important role. Molecular docking showed baicalein, the core component of SBG, had a
strong binding ability to all hub targets. Next, in DCD rats, baicalein was proven to improve liver function, alleviate pathological injury and apoptosis, and increase the survival rate. Baicalein also significantly affected the expression of 7 hub genes. Furthermore, baicalein could inhibit ferroptosis by inhibiting phospholipid peroxidation.

Conclusion:

Baicalein, the main component of SBG, could alleviate IRI, affect the expression of hub genes, and inhibit ferroptosis in LT.
Virtual and in-person exchanges: Student perspectives on advantages and disadvantages
Authors: Martinsen Rob A. , Thompson Gregory L.
Published: July 2024

Interacting with target-language speakers online has become an important way for many second language students around the world to improve their skills in their target language. These types of learning interactions can take place on a wide range of online platforms, whether paid or unpaid, one-on-one or in small groups. Although research on these types of activities, often called virtual exchanges (VE), has increased, relatively little research has compared students’ experiences across different platforms. The present study compared the experiences of first and second-year university students with native speakers in in-person interactions as well as through several online services that connect language learners. Results indicate that students claimed to learn more in the in-person interactions than in the online settings. They also claimed to feel less anxiety in the in-person interactions. However, they also felt that certain online services improved their language learning in ways that were similar to the in-person interactions. In addition, each online or in-person setting offered unique advantages and disadvantages in terms of practicality and learning.
Riesgo de expansión de Fusarium oxysporum f. cubense (Nectriaceae) ante el cambio climático en Ecuador continental
Authors: Ferrer-Sánchez Yarelys , Barahona-Manzaba Domenica Gabriela , Plasencia Vázquez Alexis Herminio , Abasolo-Pacheco Fernando
Published: July 2024

Antecedentes y Objetivos: El hongo Fusarium oxysporum f. cubense afecta fuertemente al plátano. Debido a los cambios climáticos que se prevén, particularmente en Ecuador, la expansión de este patógeno se podría ver favorecida y provocar pérdidas económicas considerables para la agricultura. Por ello, en esta investigación se evaluaron los cambios en la distribución geográfica potencial de F. oxysporum f. cubense en Ecuador continental ante varios escenarios de cambio climático. Métodos: Se utilizaron 77 registros de F. oxysporum f. cubense extraídos de bases de datos internacionales y de la literatura científica. Las variables bioclimáticas se tomaron de Worldclim, para la actualidad y para 2050 y 2070, bajo diferentes escenarios de cambio climático. Con el algoritmo de Máxima Entropía se obtuvo el modelo de nicho climático de la especie y se proyectó a un escenario de emisiones de gases mitigador (SSP-126), uno cauteloso (SSP-245) y otro extremo (SSP-585).Resultados clave: El modelo tuvo buen rendimiento y predice adecuadamente las zonas con condiciones ambientales similares a los sitios con registros de presencia de F. oxysporum f. cubense. Las condiciones favorables aparecen principalmente en la región Sierra y Costa. Bajo los escenarios climáticos, la mayor expansión de condiciones favorables se dará en la región Costa, en el escenario de mitigación (SSP-126) para 2050, con un aumento de 18,550 km2 respecto a la distribución potencial actual. Conclusiones: Si las emisiones de gases de efecto invernadero generan un clima en 2050 como el simulado en el SSP-126, las condiciones favorables para este hongo superarán a las actuales y se expandirá dentro de la Costa hacia las zonas de producción de banano. Esto provocará un impacto negativo en la economía de los productores bananeros.
Evolution of Digital Health and Exploration of Patented Technologies (2017-2021): Bibliometric Analysis
Authors: Gu Wenjun , Wang Jinhua , Zhang Yunqi , Liang Shaolin , Ai Zisheng , Li Jiyu
Published: July 2024

Background

The significant impact of digital health emerged prominently during the COVID-19 pandemic. Despite this, there is a paucity of bibliometric analyses focusing on technologies within the field of digital health patents. Patents offer a wealth of insights into technologies, commercial prospects, and competitive landscapes, often undisclosed in other publications. Given the rapid evolution of the digital health industry, safeguarding algorithms, software, and advanced surgical devices through patent systems is imperative. The patent system simultaneously acts as a valuable repository of technological knowledge, accessible to researchers. This accessibility facilitates the enhancement of existing technologies and the advancement of medical equipment, ultimately contributing to public health improvement and meeting public demands.

Objective

The primary objective of this study is to gain a more profound understanding of technology hotspots and development trends within the field of digital health.

Methods

Using a bibliometric analysis methodology, we assessed the global technological output reflected in patents on digital health published between 2017 and 2021. Using Citespace5.1R8 and Excel 2016, we conducted bibliometric visualization and comparative analyses of key metrics, including national contributions, institutional affiliations, inventor profiles, and technology topics.

Results

A total of 15,763 digital health patents were identified as published between 2017 and 2021. The China National Intellectual Property Administration secured the top position with 7253 published patents, whereas Koninklijke Philips emerged as the leading institution with 329 patents. Notably, Assaf Govari emerged as the most prolific inventor. Technology hot spots encompassed categories such as “Medical Equipment and Information Systems,” “Image Analysis,” and “Electrical Diagnosis,” classified by Derwent Manual Code. A patent related to the technique of receiving and transmitting data through microchips garnered the highest citation, attributed to the patentee Covidien LP.

Conclusions

The trajectory of digital health patents has been growing since 2017, primarily propelled by China, the United States, and Japan. Applications in health interventions and enhancements in surgical devices represent the predominant scenarios for digital health technology. Algorithms emerged as the pivotal technologies protected by patents, whereas techniques related to data transfer, storage, and exchange in the digital health domain are anticipated to be focal points in forthcoming basic research.
Persepsi Fairness dalam Romantic Relationship pada Perempuan Emerging Adulthood
Authors: Permana Muhammad Zein , Putri Ferren Azzahra
Published: July 2024

This research aims to explore the perceptions of emerging adult women (aged 18-25 years) regarding fairness in Romantic Relationships. A total of 243 participants with an average age of 18 years (M = 22.5) answered open-ended questions about their perceptions of fairness in Romantic Relationships. The interview results were then analyzed thematically and categorized to obtain themes related to fairness in Romantic Relationships. Through qualitative methods with thematic analysis, it was found that fairness in Romantic Relationships is perceived when: 1) There is reciprocity, meaning the relationship is mutual or two-way; 2) There are shared goals; 3) There is equity or fairness, indicating that treatment in the relationship can be predicted; 4) There is no discrimination, meaning there is no differential or special treatment due to certain factors such as gender; 5) There is self-awareness, meaning both parties are aware of fulfilling their rights and obligations. These five themes appear to be in different psychological explanation domains, namely personal, interpersonal or relational, group, and even intergroup. These findings demonstrate the novelty of the fairness concept, which makes it understandable that research and interventions on fairness in romantic relationships have not yet been successful. This is because fairness concepts have been explained only in the interpersonal or relational domain so far, whereas this research finding indicates three other interconnected explanation domains that define the fairness concept in romantic relationships.
AFATINIB-A COMPREHENSIVE REVIEW OF ANALYTICAL METHODS DEVELOPED IN PHARMACEUTICALS AND BIOLOGICAL MATRICES
Authors: KUMAR HEMANTH , KUMAR LALIT , VERMA RUCHI
Published: July 2024

Afatinib is a selective irreversible ErbB family blocker that can be taken orally and has demonstrated broad-range effectiveness in preclinical studies against Epidermal Growth Factor Receptor (EGFR) mutations. The inhibition of ErbB receptors by afatinib may stop the development and spread of tumours because they are crucial for cellular proliferation and apoptosis. A modulator of the tyrosine kinase receptor known as afatinib treats specific types of metastatic non-small cell lung cancer. Afatinib has been found to produce acute liver injury, also apparent rare cases of death, and is associated with momentary elevations in serum aminotransferase levels at the time of therapy.
The analytical techniques for evaluating afatinib in pharmaceuticals and biological matrices are the main subject of this study. For each method, the important validation parameters such as linearity, detection system, retention time, mobile phase, limit of Detection (LOD), and limit of Quantification (LOQ) are examined. Additionally, the discussion includes important quality characteristics like sensitivity, specificity and technique utilised for sample preparation pertaining to bioanalytical methods.
FORMULATION, ANTIOXIDANT, AND ANTI-AGING ACTIVITY OF RUBUS FRAXINIFOLIUS FRACTION
Authors: SULISTYOWATI  , ELYA BERNA , NUR SYAMSU , ISWANDANA RADITYA
Published: July 2024

Objective: The aim of this research was to evaluate the antioxidant activity and elastase inhibition of the Rubus gel fraction as well as its physical stability for 12 w. Rubus fraxinifolius leaves were reported to have strong antioxidant and elastase enzyme inhibitory activity.
Methods: Water fraction from ultrasonic-assisted extraction (UAE) of old Rubus leaves was used and formulated into face gel preparations. Antioxidant activity 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP), and 2,2'-azino-bisphenol S (2,2'-ABPS) (3-ethylbenzothiazoline-6-sulphonic acid (ABTS), elastase inhibition, and stability test during 12 w of storage, both at room temperature (30±2 °C) or accelerated temperature (40±2 °C) were performed.
Results: The anti-aging gel showed better antioxidant activity and elastase inhibition on F1 (3%) at both conditions compared to F2 (4%) and F3 (5%). The physical stability test met the requirements. However, there was a slight decrease in antioxidant activity and elastase inhibition after 12 w of storage at 30±2 °C and 40±2 °C (F1, F2, and F3).
Conclusion: The F1 met the standards and was relatively stable at 30±2 °C during 12 w of storage.
Superinfrastructures. Supercities. Superdutch.
Authors: Nan Christina
Published: July 2024

Degree Show Catalogue from an ESALA MArch (Modular Pathway) studio ‘SuperInfrastructures. SuperCities. SuperDutch. [Dutch] Territorial [Machine] Fictions’. Studio Leader: Cristina Nan. Tutors: Michael Lewis and Jonathan Lynn. 2019-2020.
Architecture as Support Structure
Authors: Karami Sepideh
Published: July 2024

Degree Show Catalogue documenting an ESALA MArch (Modular Pathway) studio ‘Architecture as Support Structure: How to Construct a Post-Petroleum World’. Studio Leaders: Sepideh Karami and Naomi De Barr. 2023-2024.
island territories viii: Scapeland Ávila
Authors: Hawker Adrian , Bernie Victoria Clare
Published: July 2024

Degree Show Catalogue documenting an ESALA MArch (Modular Pathway) studio ‘island territories viii: Scapeland Ávila’. Studio Leaders: Adrian Hawker and Victoria Clare Bernie. 2022-2023.
Grounding Naples: Settings, Zones, Grounds, and Groundings
Authors: French Chris , Lewis Michael
Published: July 2024

Degree Show Catalogue documenting the first year of a two-year ESALA MArch (Integrated Pathway) studio, ‘Grounding Naples. Studio Leaders: Chris French and Michael Lewis. 2022-2024.
Sender Berlin: Data, Nature, and Collective Life in the Urban Milieu
Authors: Paredes Maldonado Miguel , Brooks Andrew , Faed Andrea
Published: July 2024

Degree Show Catalogue documenting an ESALA MArch (Modular Pathway) studio ‘Sender Berlin’. Studio Leaders: Miguel Paredes Maldonado, Andrew Brooks and Andrea Faed. 2022-2023.
Genome-Wide Analysis of the DNA-Binding One Zinc Finger (Dof) Family in Vigna Species: Unveiling Insights into Transcriptional Regulation
Authors: Habib Zakia , Ijaz Siddra
Published: July 2024

The Dof (DNA-Binding One Zinc Finger) transcription factor family is unique to plants and performs various functions associated with activities unique to plants, including defense mechanisms, light and phytohormone responses, and seed development and germination. Though genome-wide studies have been carried out for this family in many species, but there is scarce information about Dof genes in Vigna species. In the current study, 79 non-redundant Dof proteins including 35 of them were found in V. angularis, 33 in V. radiata, and 11 in V. unguiculata. Furthermore, a comparative study was conducted on 33 non-redundant Dof proteins found in Arabidopsis thaliana. All of the identified Dof proteins in the Vigna species were found in the nucleus, according to predicted subcellular localization, which is consistent with the Dof proteins' known function as transcription factors. Moreover. All three Vigna species have several Dof proteins with predicted nuclear localization signals, suggesting a possible function for these proteins in nuclear transport and localization. Most Dof proteins were shown to have no introns by gene structure analysis; however, a small number of genes have one or two introns. The motif distribution analysis revealed motifs that were preserved over various clusters, with certain motifs being more common in particular clusters. A phylogenetic tree was constructed to assess the evolutionary hierarchy between the Dof proteins of Arabidopsis thaliana and Vigna species that revealed four major clusters, with cluster I having the greatest number of Dof proteins. These results could contribute to a better understanding of and roles of Dof genes in Vigna species
Management of Fusarium Wilt Disease in Sesame (Sesamum indicum) through Seed Treatment and Soil Amendment
Authors: Tahir M. Nouman , Habib Amer , Ali Ansar
Published: July 2024

Sesame holds a dominant position in global agriculture, primarily due to its rich protein content. This crop, however, faces a considerable threat in the form of Fusarium wilt, caused by the destructive Fusarium oxysporum. Despite advancements in agricultural technology, a significant portion of worldwide sesame production continues to be marred by this devastating disease. To address this issue, the current study was designed to manage Fusarium wilt in sesame through a series of screening trials involving various varieties, soil amendments, and seed treatments using different chemicals. The screening trial was carried out at the Ayub Agricultural Research Institute; with disease severity recorded using the rating scale. Among the six varieties/lines assessed, two varieties (Black Till and Till-18) exhibited resistance to the disease. To combat Fusarium wilt, the efficacy of different fungicides at varying concentrations was evaluated via petri plate culture assays in laboratory conditions. Among the three fungicides tested (Topsin-M, Carbendazim, Metallaxyl+Mancozeb), Carbendazim displayed the highest disease inhibition at all concentrations, surpassing Topsin-M and Sherit. Notably, the 200 ppm concentration of Carbendazim exhibited a disease incidence of 55.74%, while the 300 ppm and 400 ppm concentrations yielded 56.13% and 56.53%, respectively. Similarly, the effectiveness of various soil amendments (Poultry manure, Rice husk, Sugarcane bagasse) at different concentrations were assessed against the test pathogen under field conditions. Among these amendments, Poultry manure exhibited the highest disease inhibition at all concentrations compared to sugarcane bagasse and rice husk. The 10% concentration of Poultry manure resulted in a disease incidence of 58.21%, whereas the 20% and 30% concentrations yielded 56.87% and 59.54%, respectively.
Biocontrol potential of Pseudomonas syringae against Emerging Phyto-Fungal Pathogens
Authors: Jarrar Ahmed Muhammad , Shoaib Amna , Malik Barizah
Published: July 2024

Fungal diseases caused by soil-borne pathogens like Macrophomina phaseolina, Fusarium oxysporum f. sp. lycopersici and Sclerotium rolfsii result in huge losses of crops including cereals, pulses, vegetables etc. hence threatening global food security. Bacterial biological control agents, such as strains of Pseudomonas, Bacillus, and Streptomyces, have been historically and currently utilized to manage soil-borne pathogens as eco-friendly alternatives in the quest for a sustainable solution.The antifungal potential of Pseudomonas syringae was assessed against the said phytopathogenic fungi through dual plate assay. The effect of bacterial metabolites was also assessed on the growth, biomass, and biochemical traits [total protein content (TPP), activity of catalase (CAT), peroxidase (POX), and polyphenol oxidase (PPO)] of the fungi. P. syringae significantly (p ≤ 0.05) inhibited the growth of M. phaseolina, S. rolfsii, and F. oxysporum f. sp. lycopersici by 80, 75, and 48%, respectively, in the dual culture assays. The various concentrations of bacterial metabolites (2, 4, 6, 8, 10, ---- 20%) significantly (p ≤ 0.05) suppressed the pathogens in a dose-dependent manner. Therefore, the biomass production of either M. phaseolina or S. rolfsii declined considerably by 65-100% with the increasing metabolite concentration from 2 to 10%, while for F. oxysporum f. sp. lycopersici, the biomass decreased by 50-100% with the concentration of 2 to16%. Inhibition in biomass production increased stress levels in the fungal cell, as indicated by enhancement in the biochemical enzymatic activity in the fungi. The study demonstrates that P. syringae effectively inhibits the growth of M. phaseolina, S. rolfsii, and F. oxysporum f. sp. lycopersici. These findings support the potential of P. syringae as an eco-friendly alternative to chemical fungicides, promoting sustainable agriculture by enhancing crop resilience and yield. Further research should focus on identifying the specific antifungal compounds in P. syringae metabolites responsible for this activity
In-Vitro Management of Erwinia amylovora caused by Fire Blight of Apple with Synthetic Chemicals
Authors: Ullah Niamat , Ahmed Basheer , Waris Muhammad , Yousuf Sarfraz
Published: July 2024

Apple (Malus pomila L) belongs to family Rosacea and it is an edible fruit; mostly utilized by different age groups. Apple trees are grown worldwide. It is considered an important fruit in the temperate region of Balochistan, Pakistan. Fire blight is caused by the pathogen Erwinia amylovora the most damaging disease of apple and other pomes orchards in the world. The aim of the present study was conducted to record the incidence of the disease and management through the use of chemicals. For this purpose, survey was conducted for disease samples from the various districts of Balochistan Viz., Quetta, Ziarat, Killa Saifullah and Kalat. Among all the districts Ziarat was found to be most severe by pathogen with 20% incidence followed by Quetta having 18.67%, Kalat14.31% and Killa Saifullah 13.44% incidence, and different chemicals, i.e. Streptomycin, Tetracycline, Gentamicin, Kasugomycin, Oxytetracycline at different doses were tested against the pathogen and all the chemicals shown great effectiveness against Erwiana amylorora In-vitro conditions. The maximum inhibition zone made by chemical streptomycin with value 15.50 and minimum value of tetracycline with 10.90.and there was no inhibition zone observed in control treatment. All the data was statistically analyzed
Stability and boundedness of solutions of certain Lienard-type non-autonomous differential equations
Authors: Abdurasid Abdullai  A. , Olutimo A. L. , Omeike M. O.
Published: July 2024

In this paper, the Liénard-type non-autonomous nonlinear differential equation ẍ+ p(t)f(x, ẋ) ẋ + q(t)g(x) = ϕ(t, x, ẋ) is investigated for uniform exponential asymptotic stability of solutions when ϕ(t, x, ẋ) ≡ 0, and uniform ultimate boundedness of solutions when ϕ(t, x, ẋ) ≠ 0, using the Lyapunov’s direct method
RESENHA DA OBRA “U2”, DE ANTÔNIO CARLOS MIGUEL, CONDENSANDO MAIS DE QUARENTA ANOS DA BANDA DE ROCK IRLANDESA
Authors: Passos Rogério Duarte Fernandes dos
Published: July 2024

Review of the book “U2”, by Antônio Carlos Miguel, illustrating more than forty years of the Irish rock band, reaching the group’s origins in the city of Dublin until their recent residency in Las Vegas in the year 2024, bringing the music in a platform on which technology, entertainment and experimentation substantiate the trajectory of artists who, at the same time, did not give up activism and religiosity in their lyrics and sound atmospheres. The text even addresses U2’s ability to reinvent itself, concluding with perspectives for its future in the music industry. Therefore, this review aims to revisit the work "U2" by Antônio Carlos Miguel (2023), which presents a textual and visual portrait of the over forty years of the career of the Irish rock band U2, composed of Bono (Paul Hewson), The Edge (Dave Evans), Adam Clayton, and Larry Mullen Junior.
Producción de lechuga (Lactuca sativa) en hidroponía en sistema Indoor con luces artificiales
Authors: Arregui María Emilia , Gargaglione Verónica , Birgi Jorge
Published: July 2024

En la localidad de Río Gallegos, el fotoperiodo disminuye en época invernal y lo torna limitante para la producción de hortícolas. Motivo por el cual, para obtener cultivos todo el año en esta zona, es necesario realizar una suplementación con luz artificial. En el presente trabajo se evaluó el crecimiento de lechuga (Lactuca sativa) variedad “Divina” en un sistema hidropónico, bajo diferentes sistemas de iluminación LED. Se aplicaron dos tratamientos de iluminación (T1): sistema de luces LED convencional doméstica (Osram Floodlight 50 Ledvance) vs. (T2): sistema de luces LED específicas para cultivos (Sistema luces VIC LED Ht 5004), con una intensidad de 250 µmol/m2 ·s y un fotoperíodo de 16 h/d. Las semillas se sembraron en noviembre de 2022, transcurridos 15 días de crecimiento, se seleccionaron 16 plantines homogéneos que fueron trasplantados al sistema hidropónico y se cosecharon luego de 24 días. Se realizaron mediciones de índice verde, peso fresco, peso seco y área foliar. La biomasa aérea fue de 6,01 gr/planta y 8,03 gr/planta para el tratamiento OSRAM y VIC, respectivamente. En cuanto a la biomasa radicular, se obtuvo 1,57 gr/planta para el primer tratamiento y para el segundo de 1,8 gr/planta, en ambos casos las diferencias no fueron significativas. El índice verde fue mayor en aquellas plantas que crecieron bajo el tratamiento VIC, demostrando un mejor estado nutricional. En cuanto al área foliar, esta fue mayor en las plantas que crecieron bajo el tratamiento OSRAM con luz doméstica, debido a que compensan la menor eficiencia fotosintética con una mayor intercepción de luz y área foliar. Este estudio evidencia que la luz LED convencional doméstica es una fuente de luz viable para el crecimiento de las plantas de lechuga y que la luz LED específica de cultivo genera plantas con una calidad nutricional superior. Es necesario ampliar la investigación evaluando la respuesta de diversas especies hortícolas ante los tratamientos lumínicos planteados en este trabajo, ya que éstas reaccionan de forma diferente a los componentes espectrales del flujo luminoso.
Comunicação, jornalismo e colonialidades do ser, do saber e do poder
Authors: Lima Bárbara , Gonçalves Juliana Soares , Silva Jr. Antonio C. Fausto da , Carvalho Carlos Alberto de , Souza Ives Teixeira
Published: July 2024

Este livro é resultado parcial da pesquisa “Comunicação, Jornalismo e Colonialidades do Saber e do Poder”, financiada pelo Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), por meio da Chamada CNPq/MCTI/FNDCT Nº 18/2021 - Faixa B - Grupos Consolidados (Processo: 406167/2021-4). Composto por trajetórias, escolhas empíricas, metodológicas e conceituais diversas, os trabalhos que constituem esta obra convergem no interesse por distintos aspectos das engrenagens e relações de poder e de saber. Nessa direção, a presente publicação amplia a possibilidade da produção científica sobre questões contemporâneas à história do Brasil e América Latina, sempre pela perspectiva das interconexões com produtos e processos comunicacionais, com investigações que se propõem a refletir sobre as colonialidades por distintas vertentes teórico-metodológicas. Diante da poderosa gama de discussões que se apresentam nos textos, as seções deste livro foram pensadas num exercício simultâneo de articular as pluralidades epistemológicas, promovendo o diálogo entre suas diferenças e singularidades. E assim, com o objetivo de facilitar o percurso de leitura, propomos as seguintes seções: Objetividades e epistemologias dissidentes; Racismo, xenofobia, machismo: modernas estratégias de desumanização; Éticas, estéticas e poéticas; Colonialidades do ser e(m) espaços institucionais de poder. Identificar e compreender as estratégias das colonialidades do poder e do saber para reconhecer como elas atravessam os processos comunicacionais e jornalísticos é o problema que perpassa a pesquisa realizada em conjunto pelos grupos Insurgente-Grupo de Pesquisa em Comunicação, Redes Textuais e Relações de Poder/Saber (UFMG), Temporona-Coletivo de Ações em Temporalidades e Narrativas (UFMG), Grupo de pesquisa Comunicação, Direitos e Igualdade - CODiG (UFT), Estudos em Tradição e Memória-EsTreMa (UFMA) e Grupo Bertha de Pesquisa (PUC Minas). Neste livro, há contribuições também de pessoas pertencentes aos grupos de pesquisa Afetos: Comunicação, Discursos e Experiências (UFMG) e Grupo de Pesquisa em Comunicação, Raça e Gênero (CORAGEM/UFMG).