bluuebunny/crossref_metadata_2025 huggingface dataset:
HE4 and CA-125 kinetics to predict outcome in patients with recurrent epithelial ovarian carcinoma: the META4 clinical trial
Authors: Fabbro Michel , Lamy Pierre-Jean , Touraine Célia , Floquet Anne , Ray-Coquard Isabelle , Mollevi Caroline
Published: January 2024

HE4 and CA-125 are used for epithelial ovarian cancer (EOC) screening, diagnosis, and follow-up. Our objective was to study HE4 and CA-125 kinetics in patients treated for recurrent EOC. Serum samples were prospectively collected before the first chemotherapy cycle and every 3 months until disease progression. Data from 89/101 patients could be analyzed. At baseline, the median CA-125 and HE4 concentrations were 210 IU/L (7–10,310) and 184 pM (31–4,836). Among the 12 patients (13%) with normal CA-125 (<35 IU/L) concentration, eight had HE4 concentration ≥75 pM, and among the 16 patients with normal HE4 concentration (18%), 12 had increased CA-125 concentration. The median nadir concentrations were 31 IU/L (3–8,744) for CA-125 and 75 pM (20–4,836) for HE4. The median times to nadir were 14 (0–130) weeks for CA-125 and 12 (0–52) weeks for HE4. In multivariate analysis, CA-125 and HE4 nadir concentrations (<35 IU/L, HR 0.35, 95% CI: 0.17–0.72 and<75 pM, HR 0.40, 95% CI: 0.20–0.79) and time to CA-125 and HE4 nadir (>14 weeks, HR 0.37, 95% CI: 0.20–0.70 and >12 weeks, HR 0.43, 95% CI: 0.23–0.83) were prognostic factors of progression-free survival. More investigations on HE4 kinetics could help to better monitor patients with CA-125 concentration within normal values.
Abdominal pseudohernia in a child after surgical correction of congenital scoliosis: case report
Authors: Nadirov Nurbek , Vissarionov Sergey , Khusainov Nikita , Filippova Alexandra , Sazonov Vitaliy
Published: January 2024

Abdominal wall relaxation is a rare complication of various surgical procedures or diseases, when the intercostal or upper lumbar nerves are affected, and the innervation of the muscles of the abdominal wall is damaged. The result is a mass that can visually mimic a ventral hernia. We present a clinical case and the results of a literature review on this topic.

Clinical case

The 2 years 5 months patient diagnosed with a congenital deformity of the spine (posterolateral hemivertebra) underwent extraction of the hemivertebra from the retroperitoneal approach. In the postoperative period, a pseudohernial protrusion of the anterior abdominal wall was observed. 4.5 months later the protrusion resolved spontaneously.

Discussion

Abdominal wall relaxation is studied worldwide and is presented primarily as clinical case reports, mainly in older patients with neurological diseases. Single cases of this pathology are described among children. The Th10-Th12 roots are most often affected. Possible manifestations include: bloating and abdominal pain, pseudo-obstruction of the small and/or large intestine, and constipation. In the described case, only unilateral bloating at rest was observed, which increased with crying and strain. The natural course and prognosis of this diagnosis are usually favorable—the recovery period, according to the literature, takes an average of 4–5 months, which also coincided with our case.

Conclusion

Pseudohernias are a rare complication and may can occur during correction of spinal deformities in children. This condition is a transient disorder of the anterior abdominal wall muscles, the cause of which may be neuropathy caused by infection, metabolic disorders, or mechanical damage. The main principles of treatment of this condition include active observation and symptomatic therapy. The prognosis is usually favorable.
Impact of early heparin therapy on mortality in critically ill patients with sepsis associated acute kidney injury: a retrospective study from the MIMIC-IV database
Authors: Zhou Zhi-Peng , Zhong Li , Liu Yan , Yang Zhen-Jia , Huang Jia-Jia , Li Da-Zheng , Chen Yu-Hua , Luan Ying-Yi , Yao Yong-Ming , Wu Ming
Published: January 2024

Background: Inflammatory-coagulation dysfunction plays an increasingly important role in sepsis associated acute kidney injury (SAKI). This study aimed to investigate whether early heparin therapy improves survival in patients with SAKI.

Methods: Patients with SAKI were identified from the Medical Information Mart for Intensive Care-IV database. The patients were divided into two groups: those who received heparin subcutaneously within 48 h after intensive care unit (ICU) admission and the control group, who received no heparin. The primary endpoint was ICU mortality, the secondary outcomes were 7-day, 14-day, 28-day, and hospital mortality. Propensity score matching (PSM), marginal structural Cox model (MSCM), and E-value analyses were performed.

Results: The study included 5623 individuals with SAKI, 2410 of whom received heparin and 3213 of whom did not. There were significant effects on ICU and 28-day mortality in the overall population with PSM. MSCM further reinforces the efficacy of heparin administration reduces ICU mortality in the general population. Stratification analysis with MSCM showed that heparin administration was associated with decreased ICU mortality at various AKI stages. Heparin use was also associated with reduced 28-day mortality in patients with only female, age >60 years, and AKI stage 3, with HRs of 0.79, 0.77, and 0.60, respectively (p < 0.05). E-value analysis suggests robustness to unmeasured confounding.

Conclusion: Early heparin therapy for patients with SAKI decreased ICU mortality. Further analysis demonstrated that heparin therapy was associated with reduced 28-day mortality rate in patients only among female, age > 60 years and AKI stage 3.
Snakebite drug discovery: high-throughput screening to identify novel snake venom metalloproteinase toxin inhibitors
Authors: Clare Rachel H. , Dawson Charlotte A. , Westhorpe Adam , Albulescu Laura-Oana , Woodley Christopher M. , Mosallam Nada , Chong Daniel J. W. , Kool Jeroen , Berry Neil G. , O’Neill Paul M. , Casewell Nicholas R.
Published: January 2024

Snakebite envenoming results in ∼100,000 deaths per year, with close to four times as many victims left with life-long sequelae. Current antivenom therapies have several limitations including high cost, variable cross-snake species efficacy and a requirement for intravenous administration in a clinical setting. Next-generation snakebite therapies are being widely investigated with the aim to improve cost, efficacy, and safety. In recent years several small molecule drugs have shown considerable promise for snakebite indication, with oral bioavailability particularly promising for community delivery rapidly after a snakebite. However, only two such drugs have entered clinical development for snakebite. To offset the risk of attrition during clinical trials and to better explore the chemical space for small molecule venom toxin inhibitors, here we describe the first high throughput drug screen against snake venom metalloproteinases (SVMPs)—a pathogenic toxin family responsible for causing haemorrhage and coagulopathy. Following validation of a 384-well fluorescent enzymatic assay, we screened a repurposed drug library of 3,547 compounds against five geographically distinct and toxin variable snake venoms. Our drug screen resulted in the identification of 14 compounds with pan-species inhibitory activity. Following secondary potency testing, four SVMP inhibitors were identified with nanomolar EC50s comparable to the previously identified matrix metalloproteinase inhibitor marimastat and superior to the metal chelator dimercaprol, doubling the current global portfolio of SVMP inhibitors. Following analysis of their chemical structure and ADME properties, two hit-to-lead compounds were identified. These clear starting points for the initiation of medicinal chemistry campaigns provide the basis for the first ever designer snakebite specific small molecules.
Innovation of control technology for smart fuzes: precise detonation and efficient damage via a ternary cascade controller
Authors: Liu Peng , Li Jian , Yu Hang , Zhang He
Published: January 2024

The traditional theory of dynamic open-loop control of fuzes has been unable to satisfy the demand for smart fuze control. After analyzing time–space recognition and process control as the basis of fuze detonation control, three key issues of smart fuze control are summarized herein. Furthermore, three types of controllers are constructed, namely, detection, state, and detonation controllers, which achieve the precise detonation control of ammunition under the interference of complex multi-physics environments, ensuring efficient damage to the target. Based on the above-mentioned controllers, the design theory of the ternary cascade control of the smart fuze is established. In addition, the technical system of the ternary cascade control theory is reviewed, and the latest progress in control strategy design, environment modeling, target modeling, and other fields is summarized in detail. Finally, the development demands and technology trends in intelligent fuze control technology for future intelligent warfare are explored.
Correlation analysis between biomechanical characteristics of taekwondo double roundhouse kick and effective scoring of electronic body protector
Authors: Jia Mengyao , Liu Lin , Huang Ruifeng , Ma Yong , Lin Shijie , Peng Qian , Xiong Jun , Wang Zhaoyi , Zheng Weitao
Published: January 2024

Objective: To explore the inherent relationship between lower limb biomechanical indicators and effective scoring values of double roundhouse kick (DRK) by taekwondo athletes, and to find key biomechanical factors that trigger effective scoring.

Methods: Using the DAEDO Protector and Scoring System (PSS) in conjunction with the Vicon optical motion capture system and Kistler 3D force plate, kinematic and dynamic indicators of the front kicking motion were obtained from 12 professional taekwondo athletes (18.00 ± 2.20 years, 182.15 ± 8.62 cm and 70.00 ± 14.82 kg). The correlation between kinematics, dynamics, and scoring values was initially analyzed using bivariate linear correlation. Subsequently, based on the results of the linear correlation analysis, a stepwise regression analysis was performed to establish a stepwise regression equation.

Results: The results reveal that during the First Hit, there is a significant positive correlation (r > 0, p < 0.05) between peak hip flexion angular velocity of the dominant leg, knee abduction angle, and peak foot horizontal plane linear velocity of the non-dominant leg with effective score. On the other hand, peak ankle flexion angular velocity of the non-dominant leg, peak foot sagittal plane linear velocity, peak hip abduction angle, and peak hip flexion angle of the dominant leg exhibit a significant negative correlation (r < 0, p < 0.05) with effective score. These correlations hold statistical significance (DW> 1.023). During the Second Hit, there is a significant positive correlation (r > 0, p < 0.05) between peak ankle internal rotation angular velocity of the dominant leg, foot coronal plane linear velocity, hip adduction angular velocity, and peak ankle internal rotation moment of the non-dominant leg with effective score. Conversely, peak hip flexion angle of the dominant leg shows a significant negative correlation (r < 0, p < 0.05) with effective score. All these variables have a statistically significant impact on effective score (DW > 1.023).

Conclusion: Explosive power, body posture, adequate terminal velocity, and body rotation have an association with effective scoring of the electronic protector. The peak angular velocity of the ankle joint of the dominant leg and the peak linear velocity of the foot horizontal plane of the non-dominant leg significantly contribute to the effectiveness score of the electronic protector.
A robust and light-weight transfer learning-based architecture for accurate detection of leaf diseases across multiple plants using less amount of images
Authors: Mazumder Md. Khairul Alam , Mridha M. F. , Alfarhood Sultan , Safran Mejdl , Abdullah-Al-Jubair Md. , Che Dunren
Published: January 2024

Leaf diseases are a global threat to crop production and food preservation. Detecting these diseases is crucial for effective management. We introduce LeafDoc-Net, a robust, lightweight transfer-learning architecture for accurately detecting leaf diseases across multiple plant species, even with limited image data. Our approach concatenates two pre-trained image classification deep learning-based models, DenseNet121 and MobileNetV2. We enhance DenseNet121 with an attention-based transition mechanism and global average pooling layers, while MobileNetV2 benefits from adding an attention module and global average pooling layers. We deepen the architecture with extra-dense layers featuring swish activation and batch normalization layers, resulting in a more robust and accurate model for diagnosing leaf-related plant diseases. LeafDoc-Net is evaluated on two distinct datasets, focused on cassava and wheat leaf diseases, demonstrating superior performance compared to existing models in accuracy, precision, recall, and AUC metrics. To gain deeper insights into the model’s performance, we utilize Grad-CAM++.
Digital image correlation techniques for motion analysis and biomechanical characterization of plants
Authors: Mylo Max D. , Poppinga Simon
Published: January 2024

Temporally and spatially complex 3D deformation processes appear in plants in a variety of ways and are difficult to quantify in detail by classical cinematographic methods. Furthermore, many biomechanical test methods, e.g. regarding compression or tension, result in quasi-2D deformations of the tested structure, which are very time-consuming to analyze manually regarding strain fields. In materials testing, the contact-free optical 2D- or 3D-digital image correlation method (2D/3D-DIC) is common practice for similar tasks, but is still rather seldom used in the fundamental biological sciences. The present review aims to highlight the possibilities of 2D/3D-DIC for the plant sciences. The equipment, software, and preparative prerequisites are introduced in detail and advantages and disadvantages are discussed. In addition to the analysis of wood and trees, where DIC has been used since the 1990s, this is demonstrated by numerous recent approaches in the contexts of parasite-host attachment, cactus joint biomechanics, fruit peel impact resistance, and slow as well as fast movement phenomena in cones and traps of carnivorous plants. Despite some technical and preparative efforts, DIC is a very powerful tool for full-field 2D/3D displacement and strain analyses of plant structures, which is suitable for numerous in-depth research questions in the fields of plant biomechanics and morphogenesis.
Exposure to models’ negative facial expressions whilst eating a vegetable decreases women’s liking of the modelled vegetable, but not their desire to eat
Authors: Edwards Katie L. , Thomas Jason M. , Higgs Suzanne , Blissett Jacqueline
Published: January 2024

Introduction

Food enjoyment can be conveyed through facial expressions. Observing others’ enjoyment of food has been found to influence adults’ desirability of liked and disliked food. Exposing adults to other eaters enjoying nutritious foods that are typically disliked (e.g., vegetables) could enhance the consumption of vegetables by young adults. However, this remains to be examined in young adult populations. This study examined the effect of models’ facial expressions towards raw broccoli on young adult women’s change in liking and change in desire to eat a modelled vegetable (raw broccoli) and a non-modelled vegetable (cucumber).

Methods

Young adult women (N = 205) were randomised to watch a video of unfamiliar adult models eating raw broccoli with a positive, negative, or neutral facial expression. Participants’ change in liking and change in desire to eat the modelled and non-modelled vegetable was examined.

Results

Observing models conveying negative facial expressions whilst eating raw broccoli resulted in a statistically significant reduction in liking ratings of broccoli, but not cucumber. There was no effect of models’ facial expressions on the change in desire to eat foods.

Discussion

These findings suggest that watching others express a negative facial expression whilst eating a raw vegetable reduces women’s liking of the modelled vegetable, in the absence of a significant change to their desire to consume these foods. This highlights the power of others’ negative facial expressions on food liking. Further work is needed to establish the effect of others’ facial expressions on vegetable intake.
Effects of affectively-loaded childhood-related photos from the IAPS on the induction of involuntary autobiographical memories in young and older adults
Authors: Navarro Beatriz , Jimeno María Verónica , Fernández-Aguilar Luz , Nieto Marta , Toledano-González Abel , Cantero María José , Ros Laura , Latorre José Miguel
Published: January 2024

Objective

Aging produces changes in emotional reactivity and the retrieval of autobiographical memories. The main aim of this study was to assess age-related differences, comparing emotion induction and autobiographical memory recall using photos from the International Affective Picture System (IAPS) that are thematically related to childhood.

Method

A cross-sectional observational study was conducted, with the participation of 327 individuals (168 young adults and 159 older adults) with no cognitive impairment and aged between 18 and 88 years. We showed the participants a set of five pictures from the IAPS, the affective content of which was related to childhood. Two of these were considered to be positive images, two negative and one neutral, according to the valence of these pictures in the literature. The main study variables were the reactions associated with emotional valence or pleasure, arousal and dominance, after viewing the photos, and the autobiographical memories retrieved by the participants.

Results

The younger adults retrieved a larger number of memories than their older counterparts. As regards the responses to the five affective pictures (IAPS) on valence, arousal and dominance (IAPS), statistically significant differences were only found for pictures 2,345 (BlackEye), with a more positive valence in the group of older adults and higher arousal in the young ones, and 2,312 (Mother), with a more positive valence in the group of older persons. A greater number of memories were retrieved for the photos that generated higher levels of pleasure, greater relaxation and greater emotional control.

Conclusion

Of the variables that may be associated with the elicitation of involuntary autobiographical memories, the most significant are age and a positive stimulus.
Effect of short video addiction on the sleep quality of college students: chain intermediary effects of physical activity and procrastination behavior
Authors: Zhao Zhe , Kou Yali
Published: January 2024

Introduction

The purpose of this study was to examine the impact of short video addiction on college students' sleep quality and to elucidate the mechanism underlying this relationship. Thus, we examined the correlation between short video addiction and sleep quality and analyzed the roles of physical activity and procrastination.

Methods

The Short Video Addiction Scale, Pittsburgh Sleep Quality Index, Aitken Procrastination Inventory, and Physical Activity Rating Scale were administered to 337 college students. Data were analyzed using SPSS 27.0. Pearson's correlation analysis and mediation analysis using the bootstrapping test were performed for the standard method bias test.

Results

(1) Overall, 25.2% of college students had problems with sleep quality (indicated by a PSQI score ≥ 8). (2) Short video addiction score is positively correlated with college students' sleep quality score; procrastination score was positively associated with both short video addiction score and sleep quality score, and physical activity score was negatively associated with them. (3) Short video addiction significantly positive predicted sleep quality (β = 0.458, P < 0.001), a significant negative predictive effect on physical exercise (β = −0.183, P < 0.001), and a significant positive effect on procrastination behavior (β = 0.246, P < 0.001). After physical exercise and procrastination behavior were entered into the regression equation, short video addiction and procrastination were significantly positive predictors of sleep quality, and physical activity was significantly negative predictor of sleep quality. (4) After accounting for the variables of age, gender, and grade, physical activity and procrastination behaviors independently mediated the association between short-video addiction and sleep quality. Physical activity and procrastination behavior acted as chain mediators in the association between short video addiction and sleep quality, with a chain mediation effect percentage of 1.04%. Short video addiction directly affects college students' sleep quality, indirectly through physical activity and procrastination behavior.
Exploring neural oscillations in numerical inductive reasoning: unveiling effects of top-down and bottom-up conflict
Authors: Yuan Shangqing , Zhang Jun , Sun Tie
Published: January 2024

Previous research has delved into the brain’s response to top-down and bottom-up conflicts in numerical inductive reasoning. However, the specific neural oscillatory patterns associated with these conflict types in numerical inductive reasoning processing have remained elusive. In this study, we employed a number series completion task in which participants had to determine whether a given target number adhered to concealed rules. Three conditions were established: an identity condition (e.g., 13, 13, 13), a perceptual mismatch condition (representing bottom-up conflict, e.g., 13 13 十三), and a rule violation condition (representing top-down conflict, e.g., 13 13 14). Our EEG results revealed significant distinctions: rule violation induced more pronounced alpha desynchronization compared to both perceptual mismatch and identity conditions. Conversely, perceptual mismatch was associated with increased theta synchronization in contrast to rule violation and the identity condition. These findings suggest that alpha desynchronization may indicate the integration of rules during top-down conflict, while theta synchronization may function as a mechanism to inhibit bottom-up perceptual interference in numerical inductive reasoning.
Trajectories of quality of life in people with diabetes mellitus: results from the survey of health, ageing and retirement in Europe
Authors: Mendorf Sarah , Heimrich Konstantin G. , Mühlhammer Hannah M. , Prell Tino , Schönenberg Aline
Published: January 2024

Introduction

Previous longitudinal studies identified various factors predicting changes in Quality of Life (QoL) in people with diabetes mellitus (PwDM). However, in these studies, the stability of QoL has not been assessed with respect to individual differences.

Methods

We studied the predictive influence of variables on the development of QoL in PwDM across three waves (2013–2017) from the cross-national panel dataset Survey of Health, Ageing, and Retirement in Europe (SHARE). To determine clinically meaningful changes in QoL, we identified minimal clinically important difference (MCID). Linear regressions and Linear Mixed Models (LMM) were conducted to determine factors associated with changes in QoL.

Results

On average, QoL remained stable across three waves in 2989 PwDM, with a marginal difference only present between the first and last wave. However, when looking at individual trajectories, 19 different longitudinal patterns of QoL were identified across the three time-points, with 38.8% of participants showing stable QoL. Linear regression linked lower QoL to female gender, less education, loneliness, reduced memory function, physical inactivity, reduced health, depression, and mobility limitations. LMM showed that the random effect of ID had the strongest impact on QoL across the three waves, suggesting highly individual QoL patterns.

Conclusion

This study enhances the understanding of the stability of QoL measures, which are often used as primary endpoints in clinical research. We demonstrated that using traditional averaging methods, QoL appears stable on group level. However, our analysis indicated that QoL should be measured on an individual level.
Effect of dynamic balance on human mental rotation task in female badminton vs. volleyball players
Authors: Amara Samiha , Al-Hadabi Badria , El-Ashkar Heba , Gmada Nabil , Habacha Hamdi , Mkaouer Bessem
Published: January 2024

Background

The present study aims to compare the mental rotation performance between two non-contact sports (i.e., badminton and volleyball) in different upright conditions (i.e., with and without dynamic balance).

Methods

Thirty-five female sports and physical education students voluntarily participated in the experiment, including fourteen specialists in badminton and twenty-one specialists in volleyball. The experiment involved a mental body rotation task with or without balance exercises on a wobble board.

Results

Badminton players outperformed volleyball players in the mental rotation tasks regardless of balance. More interestingly, the results revealed an overall decrease in reaction times when participants performed balance exercises simultaneously with mental rotation.

Discussion

Our findings suggest that introducing dynamic balance on a wobble board has immediate beneficial effects on the mental rotation performance of female badminton and volleyball players. These findings are discussed in the context of sport specificities and cognitive processing framework.
Assessing the risk of prenatal depressive symptoms in Chinese women: an integrated evaluation of serum metabolome, multivitamin supplement intake, and clinical blood indicators
Authors: Yang Rongrong , Lin Zhenguo , Cai Yanhua , Chen Nan , Zhou Ying , Zhang Jie , Hong Guolin
Published: January 2024

Background

Prenatal depressive symptoms (PDS) is a serious public health problem. This study aimed to develop an integrated panel and nomogram to assess at-risk populations by examining the association of PDS with the serum metabolome, multivitamin supplement intake, and clinical blood indicators.

Methods

This study comprised 221 pregnant women, categorized into PDS and non-PDS groups based on the Edinburgh postnatal depression scale. The participants were divided into training and test sets according to their enrollment time. We conducted logistic regression analysis to identify risk factors, and employed liquid chromatography/high resolution mass spectrometry-based serum metabolome analysis to identify metabolic biomarkers. Multiple factor analysis was used to combine risk factors, clinical blood indicators and key metabolites, and then a nomogram was developed to estimate the probability of PDS.

Results

We identified 36 important differential serum metabolites as PDS biomarkers, mainly involved in amino acid metabolism and lipid metabolism. Multivitamin intake works as a protective factor for PDS. The nomogram model, including multivitamin intake, HDL-C and three key metabolites (histidine, estrone and valylasparagine), exhibited an AUC of 0.855 in the training set and 0.774 in the test set, and the calibration curves showed good agreement, indicating that the model had good stability.

Conclusion

Our approach integrates multiple models to identify metabolic biomarkers for PDS, ensuring their robustness. Furthermore, the inclusion of dietary factors and clinical blood indicators allows for a comprehensive characterization of each participant. The analysis culminated in an intuitive nomogram based on multimodal data, displaying potential performance in initial PDS risk assessment.
Psychosocial therapeutic approaches for high-functioning autistic adults
Authors: Schweizer Tina , Endres Dominique , Dziobek Isabel , Tebartz van Elst Ludger
Published: January 2024

Autism spectrum disorder (ASD) is characterized by impaired social interaction and communication skills, repetitive behaviors, restricted interests, and specific sensory processing. Particularly, adults with high-functioning ASD often remain unrecognized, presumably due to their high compensatory skills, but at the cost of high stress, which is often linked to anxiety and depression. This may further explain the significantly high suicide rates and reduced life expectancy among individuals with ASD. Thus, providing support to high-functioning autistic adults in managing core symptoms, as well as co-occurring anxiety and depression, appears essential. To date, only a limited number of evidence-based psychosocial therapeutic options are available, and very few of them have undergone rigorous evaluation in a clinical context. To obtain a comprehensive understanding, a systematic literature search was conducted according to the PRISMA checklist, and only studies demonstrating robust methodological quality were included and discussed in this review article. Although promising initial key factors and methods have been identified, additional evidence-based studies are imperative to ascertain the optimal treatment and evaluate the long-term outcomes for adults with high-functioning ASD.
Pancreatic cancer progression and mortality predicted by depression and anxiety: a systematic review and meta-analysis protocol
Authors: Zhang Ruoqi , Wang Jing , Zhang Peitong , Zhang Zheng , Miao Rui
Published: January 2024

Although the relationship between psychological factors and pancreatic cancer outcomes has been widely discussed, controversy remains. We will for the first time systematically summarize the literature to explore the correlation of anxiety and depression to the prognosis of patients with pancreatic cancer. The findings will fill existing research gaps, informing healthcare providers about better psychological care and medical treatment. The following databases will be retrieved from their inception to July 2023: Cochrane Library, MEDLINE (PubMed), Web of Science, EMBASE, and four Chinese databases (Chinese National Knowledge Infrastructure, Wanfang Database, Chinese Biomedical Literature Database, and Chongqing VIP Chinese Science and Technology Periodical Database). The World Health Organization Clinical Trials Registry, Chinese Clinical Registry, and ClinicalTrials.gov will be searched to identify other related studies. A manual search will be performed to identify missing eligible studies based on the reference list of selected articles. The search will focus on studies published in Chinese or English. To assess the risk of bias in the selected articles, Newcastle-Ottawa Quality Assessment Scale (NOS) will be used for the cohort study. Funnel plots and Egger's test will be used to assess whether publication bias exists. Moreover, the Grading of Recommendations Assessment Development and Evaluation (GRADE) will be utilized to analyze the credibility of the results from selected articles. Two independent evaluators will implement the study selection and data extraction, as well as evaluate the risk of bias and evidence quality. Data will be analyzed using Stata 16.0.

Trial registration: PROSPERO registration number is CRD42022366232.
Prescribed psychotropic medication patterns among treated Foster Care enrollees: a single institution study
Authors: Cosme Celica Glenn , Rudig Nathan O. , Borsellino Philip J. , Chea Deanna , Krider Reese I. , Durette Lisa
Published: January 2024

Background

While several state-based studies have shown that children in foster care are more likely to be prescribed psychotropic medications and experience concomitant medication use both within and among medication class, these patterns have not been explored in the state of Nevada, which lacks state mandated oversight of psychotropic prescribing for foster care enrolled youth.

Methods

Data from an electronic medical record system from a single institution were analyzed to examine the prevalence of psychotropic prescribing and concomitant medication use in children ages 2 to 19 who were enrolled and received psychotropic prescriptions between July 2019 to June 2022.

Results

Out of 569 distinct psychotropic medication treatment episodes within this cohort, the most frequent psychotropic classes prescribed were non-stimulant ADHD medications (alpha-agonists and atomoxetine, 31.5%), atypical antipsychotics (22.1%), antidepressants (20.6%), and stimulants (16.0%). The use of stimulants and non-stimulant ADHD medications decreased in older age groups while the use of antidepressants and antipsychotics increased in older age groups. During the three-year period studied, 24.0% of psychotropic medications prescriptions increased in dosage. Treatments were prescribed for only one month in 43.8% of youth. In children prescribed psychotropic medications, concomitant medication use for at least 60 days occurred in 28.0% of children who had any psychotropic medication prescribed.

Conclusion

Within the cohort of 273 foster care enrolled subjects aged 2 to 19 years old who received psychotropic medication prescriptions, non-stimulant ADHD medications (both alpha-agonists and atomoxetine) and atypical antipsychotics were more commonly co-prescribed additional psychotropic medication compared to other co-prescribed medication categories. This study illustrates prescribing patterns in a community mental health clinic focused on judicious prescribing of psychotropic medications in foster care enrolled youth. Despite this, 41% of the youth treated in this clinic received at least one prescription for psychotropic medication, and of those, 27.8% were prescribed more than one psychotropic medication at the same time. More studies are necessary to understand the underlying causes of high prevalence of concomitant medication use and prescribing practices of psychotropic medications use in foster care involved pediatric populations.
Cultural adaptation, content, and protocol of a feasibility study of school-based “Let’s learn about emotions” intervention for Finnish primary school children
Authors: Sourander A. , Ishikawa S. , Ståhlberg T. , Kishida K. , Mori Y. , Matsubara K. , Zhang X. , Hida N. , Korpilahti-Leino T. , Ristkari T. , Torii S. , Gilbert S. , Hinkka-Yli-Salomäki S. , Savolainen H. , Närhi V.
Published: January 2024

Introduction

Emotional awareness and emotion regulation are crucial for cognitive and socio-emotional development in children. School-based interventions on socio-emotional skills have the potential to prevent these problems and promote well-being of children. The Japanese school-based program, Universal Unified Prevention Program for Diverse Disorders (Up2-D2), has shown preventive effects on mental health of children in Japan. The aims of this protocol paper are to describe the unique process of adapting the Up2-D2 from Eastern to Western context, and to present a feasibility study of the intervention, conducted in Finland.

Methods

The cultural adaptation process started with the linguistic translation of materials, followed by the modification of language to fit the Finnish context. While the Japanese ideology was saved, some content was adapted to fit Finnish school children. Further modifications were made based on feedback from pupils and teachers. The Finnish version of the program was named “Let’s learn about emotions” and consisted of 12 sessions and targeted 8- to 12-year-old pupils. A teacher education plan was established to assist Finnish teachers with the intervention, including a workshop, teachers’ manual, brief introductory videos, and online support sessions. A feasibility study involving 512 4th graders in the City of Hyvinkää, South of Finland, was conducted. It assessed emotional and behavioral problems, classroom climate, bullying, loneliness, perception of school environment, knowledge of emotional awareness, and program acceptability.

Discussion

The originality of this study underlies in the East–West adaptation of a cognitive behavioral therapy-based program. If promising feasibility findings are replicated in Finland, it could pave the way for further research on implementing such programs in diverse contexts and cultures, promoting coping skills, awareness, social skills and early prevention of child mental health problems.

Ethics

The ethical board of the University of Turku gave ethics approval for this research. The educational board of the City of Hyvinkää accepted this study.
Challenges for the prevention of hypertension among international migrants in Latin America: prioritizing the health of migrants in healthcare systems
Authors: Rada Isabel , Cabieses Baltica
Published: January 2024

Among the health priorities of international migrants, non-communicable diseases such as hypertension are of major interest due to their increasing prevalence, mainly in low- and middle-income countries. Previous evidence has reported a significant risk of hypertension in international migrants derived from multiple exposures during the migration process and at the destination, such as living conditions, health literacy and access to preventive services. Also, poorer disease control has been found compared to the local population. Considering existing deficiencies in access and use of healthcare services related to hypertension prevention and continuity of care of migrants globally, we aimed to offer a Latin American perspective of the challenges faced by international migrants residing in Latin America in accessing hypertension preventive care from a human rights, equity, and universal primary healthcare approaches. From a health systems perspective, we conducted a scoping review of scientific literature on hypertension prevention and control among international migrants in Latin America and the Caribbean. Based on the findings, we discuss the potential influence of migration and health policies on healthcare systems and individual and structural barriers to healthcare access, including lack of insurance, linguistic barriers, limited intercultural competence, and geographical and financial barriers. From existing evidence related to hypertension, we highlight the particular healthcare needs of migrants and their implications for regional public health goals. This aligns with promoting culturally tailored interventions considering the migration process, lifestyle patterns, structural vulnerabilities, and gender particularities in hypertension prevention, diagnosis, and treatment. We advocate for developing universal, voluntary, and systemic regional screening and disease control initiatives in Latin America for hypertension and other chronic conditions.
Emotional distress and multimorbidity patterns in Chinese Han patients with osteoporosis: a network analysis
Authors: Wang Huiyao , Xia Qian , Dong Zaiquan , Guo Wanjun , Deng Wei , Zhang Lan , Kuang Weihong , Li Tao
Published: January 2024

With the aging of the population, the prevalence of osteoporosis and multimorbidity is increasing. Patients with osteoporosis often experience varying levels of emotional distress, including anxiety and depression. However, few studies have explored the patterns of multiple conditions and their impact on patients’ emotional distress. Here, we conducted a network analysis to explore the patterns of multimorbidities and their impact on emotional distress in 13,359 Chinese Han patients with osteoporosis. The results showed that multimorbidity was prevalent in Chinese patients with osteoporosis and increased with age, and was more frequent in males than in females, with the most common pattern of multimorbidity being osteoporosis and essential (primary) hypertension. Finally, we found that patients’ emotional distress increased with the number of multimorbidities, especially in female patients, and identified eight multimorbidities with high correlation to patients’ emotional distress.
The influencing factors of participation in time banking volunteer service for older adults among university students in Nanjing, China
Authors: Wu Yue , Liu Siyu , Song Yating , Zhang Zhirui , Liu Yunlong
Published: January 2024

Objective

This study aims to identify factors influencing university students' participation in time banking volunteer services for older adults and provides evidence to promote the involvement.

Methods

Conducted in November 2022, we utilized a convenience sampling method to recruit students from the School of Aging Service and Management at Nanjing University of Chinese Medicine, China. Data was collected through an online questionnaire focusing on various aspects related to time banking volunteer services for older adults. Factor analysis was employed to extract variables, and logistic regression was applied to identify key determinants.

Results

A significant majority (82.67%) of participants expressed willingness to engage in volunteer services for older adults. Factor analysis uncovered six influential factors explaining 62.55% of the variance. Logistic regression highlighted four key determinants of students' willingness: value judgment (OR = 4.392, CI = 2.897–6.658), social support (OR = 1.262, CI = 0.938–1.975), social influence (OR = 1.777, CI = 1.598–3.799), and socioeconomic conditions (OR = 1.174, CI = 1.891–3.046).

Conclusion

To foster sustainability and continuous time banking among university students majoring in aging service and management, a multifaceted support involving governmental, social, and university is recommended.
Does environmental regulation lessen health risks? Evidence from Chinese cities
Authors: Xu Qingqing , Wang Liyun , Hou Hanxue , Han ZhengChang , Xue Wenhao
Published: January 2024

Introduction

Atmospheric pollution is a severe problem confronting the world today, endangering not only natural ecosystem equilibrium but also human life and health. As a result, governments have enacted environmental regulations to minimize pollutant emissions, enhance air quality and protect public health. In this setting, it is critical to explore the health implications of environmental regulation.

Methods

Based on city panel data from 2009 to 2020, the influence of environmental regulatory intensity on health risks in China is examined in this study.

Results

It is discovered that enhanced environmental regulation significantly reduces health risks in cities, with each 1-unit increase in the degree of environmental regulation lowering the total number of local premature deaths from stroke, ischemic heart disease, and lung cancer by approximately 15.4%, a finding that remains true after multiple robustness tests. Furthermore, advances in science and technology are shown to boost the health benefits from environmental regulation. We also discover that inland cities, southern cities, and non-low-carbon pilot cities benefit more from environmental regulation.

Discussion

The results of this research can serve as a theoretical and empirical foundation for comprehending the social welfare consequences of environmental regulation and for guiding environmental regulation decision-making.
Dietary trends and obesity in Saudi Arabia
Authors: Alhusseini Noara , Alsinan Nawra , Almutahhar Shahad , Khader Majd , Tamimi Rawand , Elsarrag Mazin Ibrahim , Warar Rabah , Alnasser Sara , Ramadan Majed , Omair Aamir , Aouabdi Sihem , Saleem Rimah , Alabadi-Bierman Alaa
Published: January 2024

Introduction

Dietary habits in Saudi Arabia have been shifting toward the Western diet, which is high in fat, salt, and sugar, leading to a high obesity rate. Different dietary strategies such as the Ketogenic Diet (KD), Intermittent Fasting (IF), Gluten Free Diet (GFD), and Calorie Restriction Diet (CRD) have shown an influential role in weight loss. This study aimed to compare trending diets and correlate different types of diet with obesity and lifestyle among adults in Saudi Arabia.

Methods

A cross-sectional study was performed on Saudis and non-Saudis over 18 years old. We used convenience sampling, an online questionnaire distributed via social media channels, including WhatsApp, LinkedIn, and Twitter. SPSS 28 software was applied for data analysis. The chi-square test was used to determine associations between different variables. Statistical significance was considered at a value of p less than 0.05.

Results

Most participants were females residing in the Eastern and Central regions of Saudi Arabia. Although most do not follow any dietary plan, they exhibited acceptable exercise and lifestyle. The minority of the study population followed different types of diet plans, such as KD, IF, and GFD. The purpose of most of the participants who have used these strategies was for weight loss but failed to sustain the dietary plan for more than 1 month.

Conclusion

Obesity remains a challenging issue in Saudi Arabia. Adherence to dietary regimes could help in controlling obesity. Increasing the awareness of the benefits of each dietary plan for health, choosing the appropriate one, and sustaining a balanced nutrition pattern.
Implementing a social innovation for community-based peer support for immigrant mothers in Sweden: a mixed-methods process evaluation
Authors: Kåks Per , Stansert Katzen Linnea , Målqvist Mats , Bergström Anna , Herzig van Wees Sibylle
Published: January 2024

Introduction

A South African social innovation based on peer support for mothers was contextualized in southern Sweden. The objective of the project was to support expectant women and mothers of young children in immigrant communities to access public services that would benefit maternal and child health. This study aimed to assess how the intervention was implemented, what the contextual barriers and facilitators were, and how the implementation was perceived by those who delivered and received it.

Methods

The study used mixed methods with a convergent parallel design and followed the Medical Research Council guidance on process evaluations of complex interventions. Semi-structured interviews (n = 19) were conducted with peer supporters, client mothers, and key stakeholders involved in the intervention. The qualitative data were analyzed using content analysis. Quantitative data on peer supporters' activities were collected during contacts with client mothers and were presented descriptively.

Results

The five peer supporters had 1,294 contacts with client mothers, of which 507 were first-time contacts. The reach was perceived as wide, and the dose of the intervention was tailored to individual needs. Barriers to implementation included community mistrust of social services, norms on gender roles and parenting, and funding challenges. The implementation was facilitated by the organization's reputation, network, experience, and third-sector affiliation. Peer supporters tended to prioritize linking clients to other services over the educational components of the intervention, sometimes doing more than what was originally planned. Implementation strategies used included building trust, using multiple outreach venues, using internal support structures, and providing practical assistance as an entry point to comprehensive psychosocial support. The personal connection between peer supporters and clients was highly valued, and the building of relationships enabled them to address sensitive topics. Peer supporters sometimes experienced a blurred line between professional and personal roles.

Conclusions

Peer supporters used a variety of strategies to navigate identified barriers and facilitators. Trust was central both as a contextual factor and a strategy for implementation. It is valuable to maintain a balance between flexibility and adherence to the function of peer supporters. Further research is needed to evaluate the effects of the intervention.