bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimization of Ligature/Bone Defect-Induced Periodontitis Model in Rats
Authors: Gao Jingyi , Cai Simin , Li Dan , Wang Zijie , Ou Minyi , Zhang Xinlu , Tian Zhihui
Published: September 2021

Background

The destruction of alveolar bone is a crucial manifestation of severe periodontitis, which stem cell-based bioengineered therapies are expected to cure. Therefore, a cost-effective, reproducible, quantifiability and easier-to-administrate animal model that mimics human periodontitis is of great importance for further endeavor.
Methods

In this study, we created periodontitis rat models in silk ligation group, bone defect group and bone defect/silk ligation group respectively. he clinical indexes of periodontitis were observed and recorded. The mandible was taken for micro-computed tomographic, histological and histomorphometric analysis to assess the periodontal inflammation and bone remodeling
Results

Obvious periodontal inflammation but slight alveolar bone resorption were observed in the ligation group, while surgical trauma was not robust enough to continually worsen the constructed bone defect area in the bone defect group. In the bone defect/ligature group, obvious and stable periodontal inflammation could be the most lasting with similar evolving pathological patterns of human periodontitis. It also exhibited enhanced clinical similarity and confirmed its superiority in quantitativeness.
Conclusions

The present rat model is the first study to reproduce a pathological process similar to human periodontitis with reliable stability and repeatability, manifesting a priority to previous methods. Day 9 to Day 12 is the best time for reproducing severe periodontitis syndromes with vertical bone resorption in this model.
A Young Japanese Patient with Spinocerebellar Ataxia Type 3 Presenting Depressive State with Cenesthopathy and Delusion: A Case Report
Authors: Okamoto Naomichi , IKENOUCHI ATSUKO , Ide Satoru , Hashimoto Yu , Yoshimura Reiji
Published: September 2021

Background: Depressive state is a common complication of spinocerebellar ataxia type 3 (SCA3). To the best of our knowledge, cases of SCA3 presenting with psychotic symptoms (i.e., cenesthopathy) have not been described. Here, we present a case of severe depressive state with cenesthopathy and delusion in a young Japanese man with SCA3.Case presentation: A 43-year-old Japanese man with SCA3 developed severe depressive state with associated cenesthopathy and delusion. He was treated with escitalopram (10 mg/day) and olanzapine (2.5 mg/day). Computed tomography showed atrophy of the cerebellum, bilateral superior cerebellar peduncle, and tegmentum of the pons. Single-photon emission computed tomography demonstrated reduced blood flow in the cerebellum, vermis, and brainstem. After eight weeks, his depressive state and delusion improved however his cenesthopathy persisted. Conclusions: We encountered a case of severe state with psychotic features (i.e., cenesthopathy and delusion) in a young Japanese man with SCA3. This study demonstrates that SCA3 may inherently present with severe depressive state and unique psychotic symptoms, even in younger patients where age-related neurodegeneration is unlikely. The complex function of the cerebellum in emotion and perception may play a crucial in the emergence of these psychiatric symptoms.
How to Improve the Manpower Shortage of Coastal Hotels Under the COVID-19 Epidemic Environment! Explore the Effectiveness of the Hotel Internship Training System
Authors: Xue Bing-Wang , Lin Hsiao-Hsien , Chen Chao-Chien , Lee Peng-Yeh , Hsu Chin-Hsien
Published: September 2021

This study aimed to investigate the key factors of sustainability of hotel social responsibility from the effectiveness of the hotel intern training system. Using a mixed research method, a sample was first selected by purposive sampling, and 280 questionnaires were obtained by snowballing from September 2019 to February 2020. Using Statistical package for social sciences (SPSS, AMOS) IBM 22.0 software, the reliability of the questionnaires was confirmed by the CFA method, examined by Pearson Correlation Analysis, and then the opinions of hoteliers, experts, and senior employees on the questionnaire results were obtained by interview method and finally, the data were compiled and analyzed by multivariate verification. The study found that: Chinese hoteliers are unable to stabilize their employees' motivation and fulfill their internal social responsibility due to insufficient human resource training system, welfare benefits, job rotation mechanism, and poorly defined reward and punishment system. In order to stabilize the implementation of perfect internal corporate responsibilities for entrepreneurs, it is necessary to strengthen corporate culture promotion, improve the existing promotion system, increase employee benefits, and adjust the working environment and facilities. In this way, even in a harsh working environment, it can still increase employees' recognition of the company, improve work performance, and increase employees' willingness to stay.
Long-term effects of reducing the dialysate calcium concentration on bone biomarkers in adult patients on peritoneal dialysis
Authors: Piraciaba Maria , Cordeiro Lilian , Guimarães Erica Adelina , Abensur Hugo , Pereira Benedito Jorge , Jorgetti Vanda , Moysés Rosa Affonso , Elias Rosilene Motta
Published: September 2021

Introduction:
Patients on peritoneal dialysis (PD) are usually exposed to a high dialysate calcium concentration (D[Ca]), which is associated with undesirable effects. Low D[Ca] might overstimulate parathyroid hormone (PTH), as shown by previous studies carried out before the incorporation of calcimimetics in clinical practice. We hypothesized that a reduction in D[Ca] is safe and without risk for a rise in serum PTH.
Methods
in this prospective study, the D[Ca] was reduced from 1.75 mmol/L to 1.25 mmol/L for one year in prevalent patients on PD. Demographic, clinical, and biochemical parameters were evaluated at baseline, 3, 6, and 12 months of follow-up.
Results
Patients (N = 20) aged 56 ± 16 years, 50% male, 25% diabetic. There was no significant change in calcium, phosphate, alkaline phosphatase, 25(OH)-vitamin D or PTH over time. Medication adjustments included an increase in calcitriol and sevelamer. After 1 year, absolute and percentual change in PTH levels were 36 (-58, 139) pg/ml, and 20% (-28, 45) respectively. The proportion of patients with PTH > 300 pg/ml did not change during the follow-up (p = 0.173).
Conclusion
Low D[Ca] concentration should be considered to patients on PD as a valuable and safe option. Medication adjustments to detain PTH rising, however, are advised.
The Relationship Between Tooth Loss and Hypertension: a Systematic Review and Meta-analysis
Authors: Tada Akio , Tano Rumi , Miura Hiroko
Published: September 2021

Understanding association between tooth loss and hypertension is important for improving cardiovascular health. We searched for publications that were published between July 2011 and June 2021 using three electronic databases (PubMed, EMBASE, and Scopus) and conducted a systematic review and meta-analysis on the association between tooth loss and hypertension. Quality assessments were performed using the Critical Appraisal Skills Program guideline, Newcastle–Ottawa Scale and the GRADE approach. Twenty studies (17 cross-sectional studies, and 3 cohort studies) met the inclusion criteria for this review. Most cross-sectional studies showed that subjects with more tooth loss exhibited a greater proportion of hypertension and higher systolic blood pressure than those with less tooth loss. Meta-analyses revealed a statistically significant association between tooth loss and hypertension. The pooled ORFs of hypertension for having tooth loss with no tooth loss and for edentulous with dentate were 2.22 (95% CI 2.00-2.45) and 4.94 (95% CI: 4.04–6.05), respectively. In cohort studies, subjects with more tooth loss had a greater incidence of hypertension than those with less tooth loss during the follow-up period. The present systematic review and meta-analysis suggested that tooth loss is associated with an increased risk of hypertension and higher systolic blood pressure.
Coupled Metabolome With Physiology Unveiled Mechanisms for Cadmium Affecting Active Ingredients Synthesis in Salvia Miltiorrhiza, A Non-cd-hyperaccumulator
Authors: Yuan Jun , Fu Haihui , Wang Xiaoyun
Published: September 2021

BackgroundCadmium (Cd) poses threats to human health by affecting the safety (Cd accumulation) and quantity (contents of active ingredients) of Salvia miltiorrhiza due to human activities and Cd characteristics. It remains largely unknown how Cd stress affects the synthesis of active ingredients in S. miltiorrhiza. ResultsHere we investigated physiologies (contents of Cd, malondialdehyde (MDA) and proline, and activities of superoxide dismutase, peroxidase (POD) and catalase (CAT)), transfer factor (TF), bioconcentration factor (BCF) and metabolites of S. miltiorrhiza at different levels of Cd contamination with a pot experiment. The results revealed that Cd concentration, as it rose in soil, increased significantly in roots and leaves with TFs and BCFs below 1 in the Cd addition groups; POD and CAT activities and proline content increased and then declined significantly. Besides, amino acids and organic acids (especially D-glutamine (D-Gln), L-aspartic acid (L-Asp), L-phenylalanine (L-Phe), L-tyrosine (L-Try), geranylgeranyl-PP (GGPP), and rosmarinic acid (RA)) contributed more than other metabolites in discriminating roots under different levels of Cd contamination. With Cd concentration rising, the relative content of GGPP declined and then increased significantly; RA content rose significantly; content of L-Phe and L-Try increased and then declined significantly, while the content of D-Gln and L-Try decreased and then increased significantly. Conclusions These results suggested that S. miltiorrhiza belonged to a non-Cd-hyperaccumulator with most Cd accumulated in roots; Cd enhanced the RA synthesis via regulating amino acid metabolism but inhibited the tanshinone synthesis mainly by declining the GGPP content, with proline, POD and CAT playing vital roles in resisting Cd stress.
Evaluation of Depressive Symptoms in Elderly With Glaucoma
Authors: Neto José de Paula Barbosa , Lima Luiz Eduardo Fernandes , Vasconcelos Matheus Carvalho , Amaral Luis Eduardo Reis , Verde Lise Queiroz Lima , Carneiro Amanda Galdino , Silva Paulo Goberlânio Barros , Matos Alexis Galeno
Published: September 2021

Purpose: The aim of this study was to assess the presence of depressive symptoms in elderly people with glaucoma and other clinical and epidemiological factors that were associated to the presence depression.Methods: A cross-sectional study was carried out at the Hospital de Olhos Leiria de Andrade, including volunteers aged 60 years or over. Individuals were separated into patients with glaucoma and patients without glaucoma. Volunteers responded a questionnaire, containing data from clinical history and the Geriatric Depression Scale – 15, and were submitted to a complete ophthalmological evaluation.Results: Overall, 42 patients in the glaucoma group and 40 patients in the non-glaucoma group were evaluated. The mean age among cases was 70.2 years, while in the control group it was 65.7 years. The evaluation of the Geriatric Depression Scale – 15 showed an average score of 4.21 and 3.82 in the case and control groups, respectively, with no statistical difference. However, the worsening of visual acuity was related to a greater number of depressive symptoms when comparing individuals with glaucoma. When analyzing the correlation between age, in both groups, and the number of depressive symptoms, there was no statistical significance.Conclusion: The presence of glaucoma was not associated with an increase in the Geriatric Depression Scale-15 score. However, the worsening in visual acuity was correlated to a greater number of depressive symptoms.
Artificial Intelligence in Positioning Between Tooth and Nerve on Panoramic Radiography
Authors: Choi Eunhye , Lee Soohong , Jeong Eunjae , Shin Seokwon , Youm Sekyoung , Son Youngdoo , Pang KangMi
Published: September 2021

Determining the exact positional relationship between mandibular third molar (M3) and inferior alveolar nerve (IAN) is important for surgical extractions. Panoramic radiography is the most common dental imaging test. The purposes of this study were to develop an artificial intelligence (AI) model to determine two positional relationships (true contact and bucco-lingual position) between M3 and IAN when they were overlapped in panoramic radiographs and compare its performance with that of oral and maxillofacial surgery (OMFS) specialists. A total of 571 panoramic images of M3 from 394 patients was used for this study. Among the images, 202 were classified as true contact, 246 as intimate, 61 as IAN buccal position, and 62 as IAN lingual position. A deep convolutional neural network model with ResNet-50 architecture was trained for each task. We randomly split the dataset into 75% for training and validation and 25% for testing. Model performance was superior in bucco-lingual position determination (accuracy 0.76, precision 0.83, recall 0.67, and F1 score 0.73) to true contact position determination (accuracy 0.63, precision 0.62, recall 0.63, and F1 score 0.61). AI exhibited much higher accuracy in both position determinations compared to OMFS specialists. In determining true contact position, OMFS specialists demonstrated an accuracy of 52.68% to 69.64%, while the AI showed an accuracy of 72.32%. In determining bucco-lingual position, OMFS specialists showed an accuracy of 32.26% to 48.39%, and the AI showed an accuracy of 80.65%. Moreover, Cohen’s kappa exhibited a substantial level of agreement for the AI (0.61) and poor agreements for OMFS specialists in bucco-lingual position determination. Determining the position relationship between M3 and IAN is possible using AI, especially in bucco-lingual positioning. The model could be used to support clinicians in the decision-making process for M3 treatment.
Takotsubo Cardiomyopathy in Patients Suffering From Acute Non-traumatic Subarachnoid Hemorrhage - A Single Center Follow-up Study
Authors: Molnár Csilla , Gál Judit , Szántó Dorottya , Fülöp László , Szegedi Andrea , Siró Péter , Nagy Endre V , Lengyel Szabolcs , Kappelmayer János , Fülesdi Béla
Published: September 2021

Background: Takotsubo cardiomyopathy (TTC) is an important complication of subarachnoid hemorrhage (SAH), that may delay surgical or endovascular treatment and may influence patient outcome. This prospective follow-up study intended to collect data on the prevalence, severity, influencing factors and long-term outcome of TTC in patients suffering from non-traumatic SAH. Methods: Consecutive patients admitted with the diagnosis of non-traumatic SAH were included. Intitial assessment consisted of cranial CT, Hunt-Hess, Fisher and WFNS scoring, 12-lead ECG, transthoracic echocardiography (TTE), transcranial duplex sonography and collecting laboratory parameters (CK, CK-MB, cardiac troponin T, NT-proBNP and urine metanephrine and normetanephrine). Diagnosis of TTC was based on modified Mayo criteria. TTC patients were dichotomized to mild and severe forms. Follow-up of TTE, Glasgow Outcome Scale assessment, Barthel’s and Karnofsky scoring occurred on days 30 and 180.Results: One hundred thirty six patients were included. The incidence of TTC in the entire cohort was 28.7 %; of them, 20.6% and 8.1% were mild and severe, respectively. TTC was more frequent in females (30/39; 77%) than in males (9/39; 23%) and was more severe. The occurrence of TTC was related to mFisher scores and WFNS scores. Although the severity of TTC was related to mFisher score, Hunt-Hess score, WFNS score and GCS, multivariate analysis showed the strongest relationship with mFisher scores. Ejection fraction differences between groups were present on day 30, but disappeared by day 180, whereas wall motion score index was still higher in the severe TTC group at day 180. By the end of the follow-up period (180 days), 70 (74.5%) patients survived in the non-TTC, 22 (81.5%) in the mild TTC and 3 (27%) in the severe TTC group (n = 11) (p = 0.002). At day 180, GOS, Barthel, and Karnofsky outcome scores were higher in patients in the control (non-TTC) and the mild TTC groups than in the severe TTC group. Conclusions: Takotsubo cardiomyopathy is a frequent finding in patients with SAH, and severe TTC may be present in 8% of SAH cases. The severity of TTC may be an independent predictor of mortality and outcome at 6 months after disease onset. Therefore, a regular follow-up of ECG and TTE abnormalities is warranted in patients with subrachnoid hemorrhage for early detection of TTC. Trial registration: The study was registered at the Clinical Trials Register under the registration number of NCT02659878 (date of registration: January 21, 2016)
Study on Mechanical Characteristics of Composite Alkali-activated Materials-stabilized Gold Tailings Under Direct Shear
Authors: Pan Zhenkai , Zhang Chao , Li Yuan , Gan Shucheng
Published: September 2021

In this study, the traditional industrial waste residue and some alkaline activators were mixed to prepare a new composite alkali-activated materials (CAAMs), which was used to stabilize gold mine tailings (GMTs). Due to emissions of greenhouse gases and solid dust, alkali-activated materials have been widely used to replace Portland cement to solidify geotechnical materials to enhance their mechanical properties. Different admixture of CAAMs (i.e., 0, 3, 5, 8% ) and gold mine tailings were prepared, and the samples were cured in saturated water and under no air conditions. In order to investigate the mechanical characteristics of CAAMs-stabilized GMTs, laboratory direct shear tests were carried out on samples after curing them for 3, 7, 14 and 28 days, respectively. The test results showed that as the curing periods increased, the brittleness of the samples increased, and the stress-displacement curves for all the cured specimens changed from plateau-type to peak-type curves. The curing periods and the content of CAAMs are both beneficial for enhancing the shear strength of CAAMs-stabilized GMTs samples, but the increase rate decreased as the vertical confining pressure increased. Furthermore, the influence of CAAMs content on shear strength increment was larger than that of curing periods. An exponential growth model could be well used to describe the change of shear strength with the curing periods at different vertical stresses.
The Use of Sucking Time to Establish Models to Estimate Breastmilk Intake of One Breastfeeding Session for 1-12-Month Infants: A Cross-sectional Study
Authors: Jia Ni , Xu Mengxue , Zhang Meixian , Gong Jianhua , Zhao Lu , Dai Yaohua
Published: September 2021

BackgroundObservation method of assessing breastmilk intake (BI) by observing medical indices has less interference in breastfeeding than test-weighing method, but for the calculation certain influential predictor variables had not been recognized and needed to be further studied. MethodInfants between 1 and 12 months were enrolled in a hospital of Shenzhen city in northern China. A cross-sectional survey was conducted in a sample of mother-infant dyads. A breastfeeding session of each participating mother subject was observed in the clinic. 150 mother-infant dyads were adopted for data analysis. BI was measured by test-weighing method. Sucking time (ST), Information of maternal and infant health, maternal breast, and infant feeding practice were collected. ResultsThere was a relationship between sucking time and breastmilk intake per breastfeeding session (r=0.57, p<0.05). In the 4 multilevel models (r>0.6, p<0.05) established to estimate breastmilk intake the best fit multilevel model was to estimate breastmilk intake per kg (infant weight) for 1-4-month infants (R2=0.53, p<0.05). Sucking time as the key variable and other factors including infant birth weight/ birth weight, breast side, maternal BMI, maternal vocation significantly had effect on breastmilk intake and those factors that remained significant varied according to different age groups. ConclusionsSucking time had a significant association with breastmilk intake in a breastfeeding session. Establishing multilevel models based on sucking time to estimate breastmilk intake per infant weight for specific age group of infants greatly improved the effectiveness. But the accuracy of the estimation needed to be improved for further application in telemedicine.
Chromosome length genome assembly of the redbanded stink bug, Piezodorus guildinii (Westwood).
Authors: Perera Omaththage P.
Published: September 2021

Objective: The redbanded stink bug, Piezodorus guildinii (Hemiptera: Pentatomidae), is native to Caribbean Basin and is currently considered an invasive pest in Florida, Louisiana, Mississippi, and Texas in the southern United States. Although P. guildinii is an economically important invasive pest in the USA, a relatively few studies have been conducted to understand genetic, population genetic structure, and genetic basis of resistance to insecticides. The objective of this work was to obtain a high-quality genome assembly to develop genetic resources to conduct genetic, population genetic, and physiological studies of the RBSB. Results: The genome of RBSB was sequenced with Pacific Biosciences technology followed by two rounds of scaffolding using Chicago libraries and HiC proximity ligation to obtain a high-quality assembly. The genome assembly contained 800 scaffolds larger than 1 kbp and the N50 was 170.84 Mbp. The largest scaffold was 222.22 Mbp and 90% of the genome was included in the 7 scaffolds larger than 1 Mbp. The number of megabase scaffolds also matched the number of chromosomes in this insect. The genome sequence will facilitate the development of resources to conduct studies on genetics, transcriptomics, and physiology of RBSB.
Effectiveness of standardized peri-operative protocol with combination of gentamicin and levofloxacin as prophylactic antibiotics on preventing infections after transrectal prostate biopsy: A retrospective study of 577 patients
Authors: Chiang Heng-Chieh , Lin Jesun , Yan Meng-Yi , Chen Chun-Chi , Chen Jian-Ting , Chen Pao-Hwa
Published: September 2021

PurposeThis retrospective study to determine the effectiveness standardized peri-operative protocol in combination with prophylactic gentamicin and levofloxacin in preventing infectious complications after trans-rectal prostate biopsy.Material and MethodPatients were screened for prostate cancer at our out-patient department, either due to abnormal digital examination or elevated PSA level. Patients who underwent transrectal ultrasound (TRUS) guided prostate biopsy from January 2008 to December 2012 was included in this study. After using surgical code to identify the patients, charts were reviewed, and complications were recorded. Infectious complications were defined as any patient who experienced any signs systemic inflammatory response syndrome (SIRS) within 14 days after undergoing TRUS biopsy. Complications were graded according to Clavien-Dindo classification.ResultsOut of the 577 patients there were 20 patients (3.47 %) with infectious complications. Of the 20 patients with infectious complications, only four patients (0.7%) needed hospitalization due to bacteremia. Minor complications (i.e., hematuria, acute urine retention, hematospermia, etc.) were self-resolving. There were 9 positive urine culture and 4 positive blood culture with Escherichia coli (E. coli) as the predominant species. Three patients had positive urine culture for ciprofloxacin resistant strain, which was susceptible to 2nd an 3rd generation cephalosporin or amikacin. One patient had blood culture positive for extended-spectrum beta-lactamase (ESBL) E. coli infection, which was sensitive to amikacin. The infectious complication rate and number decrease each year without increase in resistant strain.ConclusionOur current peri-operative and post-operative protocol appears to be feasible in reducing infection complications after prostate biopsy; our complication and sepsis rate were similar compared to other English literatures. A prospective randomized controlled trial would be needed to determine if a single factor or a combination of several factors are responsible for the reduction in post-biopsy infections.
Major Mistakes and Errors in the Use of Trial Sequential Analysis in Systematic Reviews or Meta-analyses – Protocol for a Systematic Review
Authors: Riberholt Christian Gunge , Olsen Markus Harboe , Milan Joachim Birch , Gluud Christian
Published: September 2021

Background: Adequately conducted systematic reviews with meta-analyses are considered the highest level of evidence and thus directly defines many clinical guidelines. However, the risk of type I and II errors in meta-analyses are substantial. Trial Sequential Analysis is a method for controlling these risks. Erroneous use of the method might lead to research waste or misleading conclusions. Methods: The current protocol describes a systematic review aimed to identify common and major mistakes and errors in the use of Trial Sequential Analysis by evaluating published systematic reviews and meta-analyses that include this method. We plan to include all studies using Trial Sequential Analysis published from 2018 to 2021, an estimated 400 to 600 publications. We will search Medical Literature Analysis and Retrieval System Online (MEDLINE) and the Cochrane Database of Systematic Reviews (CDSR), including studies with all types of participants, interventions, and outcomes. The search will begin in July 2021. Two independent reviewers will screen titles and abstracts, include relevant full text articles, extract data from the studies into a predefined checklist, and evaluate the methodological quality of the study using the AMSTAR 2 (Assessing the methodological quality of systematic reviews). Discussion: This protocol follows the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols (PRISMA-P). The identified mistakes and errors will form the basis of a reviewed guideline for the use of Trial Sequential Analysis. Appropriately controlling for type I and II errors might reduce research waste and improve quality and precision of the evidence that clinical guidelines are based upon.
RIT1 Promotes Glioma Proliferation and Invasion via the NF-ĸB/p65 pathway
Authors: Che Minggang , Lan Qing
Published: September 2021

RIT1, a member of the Ras family, has been identified as an oncogene in several malignancies. However, the expression and function of RIT1 in glioma remains to be addressed. In this study, we found RIT1 was upregulated in glioma and was associated with poor prognosis of glioma patients. Manipulating RIT1 levels in glioma cells via RNA interference significantly inhibited glioma cell proliferation and invasion in vitro whereas RIT1 overexpression exhibited the opposite effects. Mechanistically, we demonstrate that RIT1 engaged in the activation of the NF-ĸB pathway in vitro and in vivo. Furthermore, treating RIT1-overexpressing glioma cells with the p65 siRNA partially restrained their proliferation and invasion. Together these results indicate RIT1 contributes to the development and metastasis of glioma via the NF-ĸB pathway and suggest that targeting RIT1 may be a treatment strategy for this disease.
Intelligent Fault Diagnosis Based on Dynamic Convolutional Depth Domain Adaptive Network
Authors: Zhou Huafeng , Cheng Pei-Yuan , Shao Si-Yu , Zhao Yu-Wei , Yang Xin-Yu
Published: September 2021

Deep learning-based mechanical fault diagnosis method has made great achievements. A high-performance neural network model requires sufficient labelled data for training to obtain accurate classification results. Desired results mainly depends on assumption that training and testing data are collected under the same working conditions, environment and operating conditions, where the data have the same probability distribution. However, in the practical scenarios, training data and the testing data follow different distributions to some degree, and the newly collected testing data are usually unlabeled. In order to solve the problems above, a model based on transfer learning and domain adaptation is proposed to achieve efficient fault diagnosis under different data distributions. The proposed framework adapts the features extracted by multiple dynamic convolutional layers, and creatively utilizes correlation alignment(CORAL) to perform a non-linear transformation to align the second-order statistics of the two distributions for fault diagnosis, which greatly improves the accuracy of fault classification in the target domain under unlabeled data. Finally, experimental verifications have been carried out among two different datasets.
Ailanthone decreases cell viability in tongue squamous cell carcinoma via PI3K/AKT pathway
Authors: wang shuhan , Chen Xiaoyu , Zhu Xuejie , Lin Kehao , Cui Qixiao , Zheng Qiusheng , Li Defang , Wang Yuliang
Published: September 2021

To investigate the anti-tumor effect and mechanisms of ailanthone (AIL) in tongue squamous cell carcinoma (TSCC). The viability and apoptotic cell number of TCA8113 and Cal-27 cells declined and increased considerably following AIL. Hoechst 33258 staining revealed chromatin aggregation after exposure to AIL. Along with an accumulation of cleaved caspase-9, caspase-3, and PARP1, Bcl-2/Bax ratio and the levels of caspase-3, caspase-9 and PARP1 reduced after exposure to AIL treatment. Subjecting Cal-27 cells to AIL treatment led to the arrestment of the cell cycle at the G2/M phase. Nevertheless, the cell cycle of AIL-treated TCA8113 cells did not change significantly. Following AIL treatment, a decline in the expression of CDK1 and cyclin B1 was manifested by Western Blot. The p-AKT as well as the expression level of p-PI3K underwent a significant downregulation by AIL in both cells. The outcome furnishes a valuable understanding of the potential applications of AIL in treating TSCC.
Bacterial community shift and effects of the inclusion of a mixed psychrotrophic bacteria strain for sewage treatment in constructed wetland in winter seasons
Authors: xu xiaoyan , Jiang Jie , Guo Zhinan , Sun Lianglun , Tang Meizhen
Published: September 2021

The mechanism of wastewater treatment based on psychrophilic strains to improve the denitrification efficiency of constructed wetlands at low temperatures has already become a new hotspot. In this study, three mixed psychrophilic strains (Psychrobacter TM-1, Sphingobacterium TM-2 and Pseudomonas TM-3) with high capacity of denitrification were added into a vertical-flow constructed wetlands (CWs), and the effect of the mixed strains on CWs sewage treatment was evaluated. The removal efficiency of chemical oxygen demand (COD), ammonia nitrogen (NH4+-N), total nitrogen (TN) and total phosphorus (TP) was quantified to establish the degradation kinetic model and determine the best dosage of the mixed strains. The effect mechanism of the mixed strains on indigenous microbial community and the change of sewage treatment performance in low temperature constructed wetlands was clarified by high-throughput sequencing technology. The results showed that the mixed strains can effectively remove the organic pollutants (nitrogen and phosphorus) and the optimum dosage of the mixed strain was 2.5%,with average removal rates of 1.52, 2.12, 2.07 and 1.29 times than those of the control. Meanwhile, the dominant strains in the CWs were Proteobacteria (31.23–44.34%), Chloroflexi (12.04–19.05%), Actinobacteria (10.6-20.62%), Acidobacteria (8.23–11.65%), Firmicutes (2.23–15.95%) and Bacteroidetes (4.01–18.9%). These findings provide a basis for the removal of pollutants in constructed wetlands at low temperature.
Synthesis and characterization poly (2- formylpyrrole) (PFPy) by Acids catalysis and study of its particles size
Authors: Al-Hamdan ahmad , Al-Falah Ahmad , Al-Deric Fawaz , Al-ghoraibi Ibrahim
Published: September 2021

In this paper Poly (2-formyl pyrrole) (PFPy) was synthesized using hydrochloric acid as catalysis in alcohol. PFPy is green dark very fine powder. Then the polymer forms glass substrate in the reaction mixture. The resulting polymer was characterized by (FT/IR, EDX and XPS) to determine the polymer structure. The polymer was scanned by scanning electron microscope (SEM) and its film by AFM for its morphological properties. We found the polymer consisting of spherical particles with a rough surface (average diameters of 430 nm) and they formed clusters. We proposed a method for calculated particles size depending on the crystals size (by Scherrer equation) and percentage of crystallization of polymer from XRD. The average particles size is 336.7 nm. The particles size in this method may be closer to reality because the XRD includes a large number of particles and it not optional as SEM and AFM.
Duftende Ananaslilien – Blütenduft als Schlüsselmerkmal für die Anlockung bestäubender Kleinsäuger
Authors: Wester Petra
Published: September 2021

Die Blüten der südafrikanischen Ananaslilie Eucomis regia (Asparagaceae) werden von Mäusen und Rüsselspringern bestäubt. Alle zwölf Arten der Ananaslilien (Eucomis) gleichen sich in Bezug auf Form und Farbe ihrer Blütenstände und Blüten sowie im Vorhandensein von leicht zugänglichem Nektar. Schlüsselmerkmal zur Anlockung von Bestäubern ist der Blütenduft, der sich bei Aasfliegen-bestäubten und Wegwespen-bestäubten Eucomis-Arten sowie bei E. regia stark unterscheidet. Der Duft von E. regia und eine seiner Hauptkomponenten, das schwefelhaltige, nach gekochten Kartoffeln duftende Methional, wirkt anlockend auf Mäuse und Rüsselspringer.
Gattung Capsicum: Chili, Paprika und ihre wilden Verwandten
Authors: Riering Timo
Published: September 2021

Chili und Paprika sind jedem als Früchte oder Gewürz bekannt, und immer mehr Menschen bauen die Pflanzen auch selbst an. Neben den tausenden Kultursorten sind die Wildarten der Gattung Capsicum bei uns hingegen wenig bekannt, doch bietet die Gattung einige sehr spannende Arten mit interessanten Verbreitungsmechanismen.
Sommerschnitt von Hortensien für eine Blütenbildung spät im Jahr
Authors: Heukemes Dominik
Published: September 2021

Hortensien sind beliebte Gartenpflanzen. Sie können unterschiedlich stark zurückgeschnitten werden, was ihren Wuchs sowie die Blütenbildung beeinflusst. Durch einen Rückschnitt im Sommer können Hortensien noch einmal im Herbst blühen. Bei der Wahl geeigneter nektarhaltiger Sorten mit fertilen Blüten wie Hydrangea paniculata ‘Levana’, ‘Great Star’ und ‘Vanille Fraise’ wird Insekten auch noch spät im Jahr eine willkommene Nahrungspflanze angeboten.
Wildlebende Arten im Palmengarten und im Botanischen Garten Frankfurt
Authors: Schmidt Marco , Steinecke Hilke , König Andreas , Brude Elke , Dühr Klaus , Jakobus Bernd , Roth Peter , Hawickhorst Gisela , Lotz-Winter Hermine , Piepenbring Meike
Published: September 2021

Botanische Gärten sind struktur- und artenreiche städtische Lebensräume. Um eine umfassende Übersicht spontaner Artenvielfalt zu erhalten, wurden Nachweise wildlebender Arten im Palmengarten und im Botanischen Garten Frankfurt aus verschiedenen Quellen zusammengeführt und ausgewertet. Im Palmengarten sind bis jetzt 616, im Botanischen Garten 1897 wildlebende Arten bekannt, darunter auch zahlreiche Rote-Liste-Arten. Die Ergebnisse unterstreichen die Bedeutung der Gärten für die urbane Artenvielfalt.
Beyond the single-site approximation modeling of electron-phonon coupling effects on resonant inelastic X-ray scattering spectra
Authors: Bieniasz Krzysztof , Johnston Steven , Berciu Mona
Published: September 2021

Resonant inelastic X-ray scattering (RIXS) is used increasingly for characterizing low-energy collective excitations in
materials. RIXS is a powerful probe, which often requires
sophisticated theoretical descriptions to interpret the data. In
particular, the need for accurate theories describing the influence of electron-phonon (e-p) coupling on RIXS spectra is becoming timely, as instrument resolution improves and this energy regime is rapidly becoming accessible.
To date, only rather exploratory theoretical work has been
carried out for such problems. We begin to bridge this gap by
proposing a versatile variational approximation for calculating RIXS spectra in weakly doped materials, for a variety of models with diverse e-p couplings. Here, we illustrate some of its potential by studying the role of electron mobility, which is completely neglected in the widely used local approximation based on Lang-Firsov theory. Assuming that the e-p coupling is of the simplest, Holstein type, we discuss the regimes where the local approximation fails, and demonstrate that its improper use may grossly underestimate the e-p coupling strength.
YARGITAY KARARLARI IŞIĞINDA NİŞANIN BOZULMASINDA MANEVİ TAZMİNAT
Authors: ŞAHİN-ŞENGÜL Eda , ÇELT Damla Özden
Published: September 2021

Karşılıklı evlenme vaadi ile kurulan nişan akdinin bozulmasına, 4721 sayılı Türk Medeni Kanunu m.120, 121 ve 122. maddelerinde bazı sonuçlar bağlanmıştır. Bunlar sırasıyla maddi tazminat, manevi tazminat ve hediyelerin geri verilmesi istemleridir. Nişanın hangi sebeple veya kimin kusuru ile sona erdiği önemli olmaksızın, tarafların birbirlerine veya ana baba ya da onlar gibi davrananların nişanlılara verdikleri alışılmışın dışındaki hediyelerin geri istenmesi mümkündür. Maddi ve manevi tazminat istemleri ise hediyelerin geri verilmesinden farklı düzenlenmiştir. Tazminat talep edilebilmesi için öncelikle nişanın bozma yoluyla sona erdirilmiş olması gerekir. Nişan bozma dışında bir yolla sona ererse tazminat talep edilemez. Ayrıca nişanın haklı bir sebep olmaksızın bozulması veya karşı tarafın kusurunun nişanın bozulmasına sebep olması aranır. Her ne kadar doktrinde davacının kusursuz mu olması gerektiği yoksa davalıya göre daha az kusurlu olmasının yeterli mi olduğu tartışılmaktaysa da Kanunda açıkça davalının kusurlu olması gerektiği belirtilmiştir. Tüm bu koşulların yanı sıra manevi tazminat talep edilebilmesi için davacının nişanın bozulması yüzünden kişilik hakkı saldırıya uğramış olmalıdır. Bu kapsamda çalışmamız Yargıtay kararları ışığında nişanın bozulmasında istenebilecek manevi tazminatın koşullarını ve kapsamını incelemeyi amaçlamaktadır.
Eardrum perforation treatment blood plasma enriched with platelet growth factors
Authors: Kriukov A. I. , Gurov A. V. , Ermolaev A. G. , Murzakhanova Z. V. , Dubovaya T. K. , Bakhtin A. A.
Published: September 2021

Introduction. The problem of the development of acute post-traumatic otitis media has not lost its relevance. Long-term preservation of the defect of the tympanic membrane contributes to the development of chronic inflammation in the middle ear and a deterioration in the quality of life of patients.

Objective. To study the effect of blood plasma enriched with platelet growth factors on the regeneration of the tympanic membrane tissues in patients with acute post-traumatic perforation.

Materials and methods. Patients with acute post-traumatic perforation of  the  tympanic membrane were divided into the main (24 people) and control (19 people) groups. Patients of the main group in the area of perforation of the tympanic membrane were injected once by application with a clot of autoplasma, enriched with platelet growth factors. The control group patients underwent dynamic observation of the processes of natural regeneration of the tympanic membrane tissues. On the 5, 10 and 15th days, the tissue regeneration of the tympanic membranes was assessed subjectively (patient complaints, audiometry) and objectively (otoscopy with the calculation of the dynamics of the relative perforation area, otoacoustic emission).

Results. A single application of blood plasma enriched with platelet growth factors to the perforation area was significantly more often accompanied by closure of  the  tympanic membrane perforation (p ≤ 0.01) and a  decrease in  the  average relative area of the tympanic membrane perforation on days 10 and 15 of the study (p ≤ 0.01). The dynamics of the average relative area of the tympanic membrane perforation reflected a high rate of closure of the tympanic membrane defect in the main group. Better healing of the tympanic membrane in patients of the main group was accompanied by an improvement in the auditory function of the affected ear. The quality of hearing was, on average, significantly better in the patients of the main group than in the patients of the control group, both on the 10th and 15th days of observation (p ≤ 0.01).

Conclusion. Clinical use of blood plasma enriched with platelet growth factors has a beneficial effect on the rate, intensity of closure of the tympanic membrane perforation and hearing.
Assessment of population health losses due to nasal obstruction based on the concept of the global burden of disease: general approaches and research directions
Authors: Pavlova S. S. , Korneenkov A. A. , Dvorianchikov V. V. , Ryazantsev S. V. , Ryazantseva E. S. , Donskaya O. S.
Published: September 2021

The current impact of disease on society and the health care system is increasingly driven by disability rather than premature mortality. In otorhinolaryngology, there are many diseases that have a high prevalence and cause significant health losses: hearing loss, chronic tonsillitis and pharyngitis, and more. Nasal obstruction is a common symptom in clinical practice. Given the high prevalence of nasal congestion, a significant decline in quality of life, and a significant socio-economic burden in society, this symptom is often key in the treatment of patients with rhinological diseases and a significant factor in assessing the medical need for  effective treatment options for  this condition. The  resolution of  the  Council of  experts of  the  National Medical Association of Otorhinolaryngologists on problems of nasal obstruction (April 17, 2021, Sochi) states that «it is necessary to conduct a medical and statistical study of public health losses associated with diseases that cause nasal obstruction, using methods for assessing the global burden of the disease and risk factors for the development of nasal obstruction». As you know, the World Health Organization measures the global burden of disease in the number of years of life lost as a result of disability. This indicator combines years of life lost due to premature mortality and years of life lost due to health conditions that do not meet the criteria for full health. The assessment of the disease burden in our country is used quite actively, most often for diseases that lead to death. The assessment of the disease burden indicator for diseases accompanied by nasal obstruction in our country has not been carried out, although the problem of treating nasal obstruction is of high relevance. The aim of the study is to discuss issues related to the study of public health losses due to diseases that cause nasal obstruction, using methods for assessing the global burden of the disease. The article provides an overview of the causes of nasal obstruction, information about its prevalence in various diseases, and discusses the calculation of the burden of nasal obstruction and possible approaches to calculating the global burden of disease, taking into account current methodological problems in this area.
Pathogenetic bases of the use of antifibrotic therapy with Bovhyaluronidazum azoximerum in patients with new coronavirus infection COVID-19
Authors: Chernyavskaya O. A. , Osipov A. V.
Published: September 2021

One of the most likely and serious complications of the novel coronavirus infection (COVID-19) is pneumofibrosis, which can negatively affect the duration and quality of life of patients who have suffered from this disease. The appearance of fibrotic changes in COVID-19 is due to a number of pathological processes that occur in the lungs after the pathogen, the SARS- CoV-2 virus, enters there. First of all, an inflammatory response is triggered, which is mediated by macrophages and granulocytes, due to which the synthesis of pro-inflammatory cytokines, incl. IL-1, TNF, which are potent inducers of hyaluronic acid synthetase. There is a  decrease in  the  content of  fibrinolysis activators in  the  pulmonary endothelium, which contributes to the  accumulation of fibrin in the vessels of the lungs. Fibrin can escape into the interstitial space and cause the formation of sclerosing alveolitis. The increasing defeat of pneumocytes favors the release of fibrin into the lumen of the alveoli, which causes the formation of hyaline membranes. The regulation of the fibrotic process involves immunocompetent cells, primarily CD4 + T-lymphocytes, which are capable of producing cytokines, chemokines and growth factors, and these, in turn, stimulate the proliferation and differentiation of  fibroblasts, as well as their production of  collagen. The  more severe forms of  infectious process can lead to the greater risk of developing fibrotic changes. Risk factors are a large area of lung damage, the use of artificial pulmonary ventilation, ARDS, fibrosis in anamnesis. An additional role in the pathomorphogenesis of pneumofibrosis is played by smoking, external inhalation effects (inhalation of organic and inorganic dust), gastroesophageal reflux, type II diabetes mellitus, genetic factors (familial idiopathic pulmonary fibrosis). The pathogenetic features of COVID-19 require administration of anti-fibrotic treatment. Bovhyaluronidazum azoximerum, a drug that is a conjugate of the proteolytic enzyme hyaluronidase, is considered as an antifibrotic agent. The treatment regimens with this drug recommended in the period of convalescence for patients who have undergone COVID-19 are given.
Study of the medicine MestaMidin®-nos virucidal activity of against influenza and ARD pathogens
Authors: Shtro A. A. , Galochkina A. V. , Nikolaeva Yu. V. , Petukhova G. D. , Fedorova V. A. , Lioznov D. A.
Published: September 2021

Introduction. Respiratory diseases have always been a serious threat to public health, but in 2020 the situation deteriorated significantly due to the rapid development of the coronavirus infection COVID-19. Due to the lack of available means of ethiotropic therapy and the still insufficient coverage of the general population with vaccination, disinfectants, as well as topical preparations that prevent the penetration of the virus into the body, play an important role in preventing the spread of infection.

Aim of the study. This work is devoted to the study of the virucidal activity of the medicine Mestamidin-nos against respiratory viruses, namely influenza A and B viruses, parainfluenza, respiratory syncytial, adenovirus and seasonal coronavirus.

Materials and methods. This study was carried out by the suspension method according to MU 3.5.2431-08 “Study and assessment of the virucidal activity of disinfectants”.

Results. It was shown that for all studied viruses the use of the compound for 60 minutes led to a complete (up to 0 lgTID50) or sufficient (4 lgTID50) decrease in the viral titer. In the case of a study of a compound with a protein load (imitating strong organic pollution), the effectiveness of the compound was significantly reduced against influenza A viruses, one of the strains of influenza B virus, adenovirus and seasonal coronavirus.

Conclusion. Based on the results of the study, it can be concluded that the effective inhibition of pathogens of influenza and acute respiratory infections using the compound MesaMidin®-nos in the absence of strong organic pollution.