bluuebunny/crossref_metadata_2025 huggingface dataset:
Governança e desempenho organizacional nas Universidades Federais Brasileiras
Authors: Gonçalves Joana Elizabete , Rodrigues Suzana Braga , Martins Henrique Cordeiro , Kilimnik Zélia Miranda
Published: June 2022

The objective of this article was to identify the influence of public governance practices on the performance of 63 (sixty-three) federal universities in the country, through multivariate statistical analysis. The results of the research indicate the governance represented by the mechanisms - structure, strategy and control - explain 63% of the observed value of performance. Suggest, however, that federal universities should improve the governance practices related to the control mechanism so that it performs better. It also indicates a need for more in-depth thinking on the benefits that good governance practices can bring to them. Thus, it is suggested that future research examine the question of governance through qualitative research and include in the sample also the private universities.
Antigone’s Choice: Tragedy and philosophy from dialectic to aporia
Authors: Romanska Magda
Published: June 2022

Shaped by Hegel, philosophy’s approach to Antigone has always been firmly rooted in all the assumptions of realism, with proper, true-to-life, consistent, and plausible characters. These characterological mimetic interpretations often feed off of each other within the context of what’s perceived as “realist” drama, with its focus on characters and their insoluble, hence tragic, conflict. Starting with the twentieth-century avant-garde, however, theatre became less and less interested in characterological mimicry as a foundation of drama and what follows, as the foundation of the theatrical experience itself. Along with the shift in our approach to character, we have also experienced a shift in our understanding of other Aristotelian components of drama (“Plot” and “Thought”) and dramatic genres (“Tragedy”). As our sense of character and Thought shifted from stable to unstable, so did our understanding of tragedy and its role at the junction of theatre and philosophy. Tragedy has shifted from dialectic to aporia, from binary to polynary. Antigone—with its multiple interpretations and critical lenses—illuminates this fundamental shift in our understanding of tragedy and, thus, the fundamental shift in the relationship between theatre and philosophy in postdramatic theatre.
Learning Khayal: Notes on Being-with
Authors: Shankar Karin
Published: June 2022

This essay is a poetic reflection on how the history and practice of Khayal, an improvisatory North Indian vocal form, provides lessons on being-with an Other. This submission is a form of ficto-critique and is based on the author's musical practice, revived via online lessons during the pandemic.
The influence of mixing technology on the uniformity and strength of cement stabilized macadam mixture
Authors: Wang Jianhong , Wang Jinyong , Wang Quanlei , Zhang Dongchang , Du Bin , Wang Huoming , Liang Xuzhi
Published: June 2022

A comparison between the two strategies: secondary traditional mixing technology and secondary vibratory mixing technology is proposed based on aggregate sieving, cement EDTA titration and unconfined compressive strength tests to explore the influence of the uniformity and strength of cement stabilized macadam mixture in the paper. The results show that when the secondary vibratory mixing technology is adopted: (1) the standard deviations and coefficients of variation of the passing rates of key sieves of 19 mm, 13.2 mm, 9.5 mm, 4.75 mm and the cement dosage titration results decrease significantly, and the mixing uniformity of the mixture is significantly improved; (2) the 7-day and 28-day unconfined compressive strengths of the mixtures are significantly improved while the strength standard deviations and coefficients of variation are reduced, with an obvious trend along with the extension of the curing time (within 28 days).
Circuit design and application for weak signal detection based on Duffing oscillator
Authors: Zhang Chenqi , Zhang Weiwei , Cheng Mengfei , Ma Hongwei , Zhang Junting , Zhou Yiqing
Published: June 2022

A design scheme of Duffing Chaotic circuit module is proposed based on Multisimin study. The operational amplifier is used to construct integrating circuit. The Duffing chaotic circuit is also designed based on the integrating circuit. The results can be shown in a virtual oscilloscope by phase trajectory. The bifurcation results of Duffing oscillator solved by the circuit module are consistent with that obtained by Matlab. The Duffing equation in critical state is selected as Chaos Inspection System (CIS), which is used to identify weak signal with strong noise. Simulation examples show that the chaotic circuit designed in this study can successfully identify many kinds of weak signals, such as sine wave, triangle wave, and square wave etc. This work provides a theoretical basis for the hardware of CIS of weak signal with strong noise.
Therapeutic Implications of Curcumin in the Treatment of Inflammatory
Eye Diseases: A Review
Authors: Thiruvengadam Muthu , Heydari Mojtaba , Khalili Mohammad Reza , Nowroozzadeh Mohammad Hossein , Bamdad Shahram , Sahebkar Amirhossein , Shariati Mohammad Ali
Published: June 2022

Curcumin is the main active constituent of the medicinal plant Curcuma longa L., used
traditionally as a medicinal spice in several ancient civilizations. Different preclinical and clinical
studies support the anti-inflammatory properties of curcumin in various inflammatory diseases. As
inflammation has an essential role in the pathophysiology of many ocular diseases, curcumin has
been suggested as a promising therapeutic agent with anti-inflammatory properties. Based on the
extent of experimental and clinical evidence, curcumin can exert protective effects against the
corneal, uveal, retinal, optic nerve, orbital, and lacrimal gland inflammatory disorders. Herein, the
available literature on the beneficial effects of curcumin in inflammatory eye diseases is reviewed.
The limitations and future directions of these investigations are also discussed.
Anticancer Drug Development: Evaluative Architecture
Authors: Lu Da-Yong , Xu Bin , Lu Ting-Ren
Published: June 2022

Anticancer drug development is complex and multi-factorial, demanding robust drug evaluative
architecture in experimental and preclinical studies. To increase the number of drug licensing, biochemical,
pharmacological, technical and economic changes (balance and integration) in evaluative systems
should be focused in labs throughout the world. Despite great progress, treatment breakthroughs and
drug industry need new ideas and more competitive technology (new generation of in vitro test systems).
Overall, drug evaluative systems comprise anticancer drug development (medicinal chemistry and pharmacology)
from initial screening to clinical validity. Its advances greatly impact the outcomes of drug
production (rates of final drug licensing and efficacy of therapeutics in the clinic). In this regard, creative
ideas and new techniques will change the norm and convention of drug screening and mechanic exploration
in the future. This article provides multi-disciplinary approaches for experimental and preclinical
anticancer drug evaluations, selections and combinations (chemistry and biomedicine). Future trends for
drug evaluative systems are especially highlighted in in-depth, multilateral and multidisciplinary approaches.
Age Related Osteoarthritis: Regenerative Therapy, Synthetic Drugs, and
Naturopathy to Combat Abnormal Signal Transduction
Authors: Mukherjee Jhumpa , Samadder Asmita , Nandi Sisir , Ahmed Tamanna , Dey Rishita
Published: June 2022

Introduction:

Osteoarthritis (OA) is a common chronic inflammatory neurodegenerative joint disorder that causes disability among the geriatric population. It involves the loss of the articular cartilage that covers the end of a long bone thereby failing to prevent the friction between the joints.

Method:

The literature on the prevalence of OA and different risk factors like physical inactivity, obesity, and joint injury was searched through Google scholar, PubMed, research gate, Wikipedia, etc for the review.

Result:

OA has affected around 303 million people globally. It affects the knee, hip, hands, and spine joints owing to common symptoms like pain, swelling, and disability. Further, OA-associated disability causes depression leading to an economic and social burden with physical isolation, thus making it more severe for older people in their day-to-day lifestyle. Presently, no permanent cure has been devel-oped for OA. Although, there are many risk factors of OA, among them, the most prominent one is considered to be “aging”. Most people crossing the age of 65–70 years have been associated with changes in the joints (one or more) about the development of OA. Several theories related to cellular aging and cell senescence with OA development. However, aging alone does not cause this condition; it is accelerated by the abnormal signal transduction followed by the progression of OA. The blueprint of possible management of OA by the different approaches has been the prime concern of this review work.

Conclusion:

An outline of the risk factors of abnormal signal transduction and different treatment ap-proaches, including regenerative therapy, synthetic drugs, and naturopathy manipulating them concern-ing OA are discussed in this review which might be an answer to the age-old issue of geriatrics.
Design, Synthesis, Docking Studies, Enzyme Inhibitory and Antiplatelet Aggregation Activities of New 1,3-Diphenyl-3-(Phenylthio)Propan-1-One Derivatives as Selective COX-2 Inhibitors
Authors: Daraei Bahram , Zarghi Afshin , Bayanati Maryam
Published: June 2022

Background:

Cancer is the second leading cause of death worldwide after heart disease. A vast number of studies indicated that selective cyclooxygenase-2 (COX-2) inhibitors could be chemopreventive against different types of cancer because the expression of COX-2 is increased. Therefore, to develop new therapeutics for cancer, the design and synthesis of new COX-2 inhibitors with few side effects seem attractive as anti-cancer agents.

Objective:

Some of the well-known drugs that have been widely used for some time have been removed from the market due to the cardiac side effects they cause, so there is a need to introduce a scaffold that can inhibit COX-2 with high potency and low side effects. This study aimed to introduce a new COX-2 inhibitor structure.

Methods:

A new series of β-aryl-β-mercapto ketones possessing a methylsulfonyl pharmacophore was synthesized and evaluated as selective COX-2 inhibitors. In-vitro COX-1 and COX-2 inhibition effects of these compounds were evaluated, and molecular modeling was examined. Also, the antiplatelet aggregation activity of the synthesized compounds was tested.

Results:

In-vitro COX-1 and COX-2 inhibition assays indicated that almost all newly synthesized compounds showed selectivity for COX-2 with IC50 values in the 0.07-0.22 μM range and COX-2 selectivity indexes in the 170 to 703.7 range. Among the tested compounds 1-(4-(methylsulfonyl)phenyl)-3-phenyl-3-(phenylthio)propan-1-one (4a), 3-(3,4- dimethoxyphenyl)-1-(4-(methylsulfonyl)phenyl)-3-(phenylthio)propan-1-one (4g) and 3-(4-fluorophenyl)-1-(4-(methyl sulfonyl)phenyl)-3-(phenylthio)propan-1-one (4h) were the most potent COX-2 inhibitors and 3-(3,4- dimethoxyphenyl)-1-(4-(methylsulfonyl)phenyl)-3-(phenylthio)propan-1-one had the highest selectivity index for COX-2 enzyme inhibitory activity. The Anti-platelet aggregation activity results indicated that the compound 1-(4- (methylsulfonyl)phenyl)-3-(phenylthio)-3-(p-tolyl)propan-1-one (4b) possesses the strong anti-platelet activity. Our molecular modeling studies also indicated that the methylsulfonyl pharmacophore group is placed into the adjunct pocket in the COX-2 active site and forms hydrogen bond interactions with NH of Arg513 and NH of His90.

Conclusion:

In brief, all designed and synthesized compounds showed moderate to good COX-2 inhibitory effects and showed good anti-platelet activity. Therefore, these compounds have the potential for further research into developing anti-cancer agents.
Postural Orthostatic Tachycardia Syndrome and Orthostatic Hypotension
Post COVID-19
Authors: Shahmohamadi Elnaz , Eslami Masoud , Mollazadeh Reza , Mirshafiee Shayan , Sehat Parisa , Alizadeh Fatemeh , Emkanjoo Zahra , Far Vahideh Laleh
Published: June 2022

Background:

Novel coronavirus causes coronavirus disease -19 (COVID-19). The hallmark
is acute respiratory distress syndrome, but other systems' involvement is less illustrated. Our goal was
to evaluate the manifestation of COVID-19 on one of the overlaps of the cardiovascular and nervous
system, namely: Postural Orthostatic Tachycardia Syndrome (POTS) and Orthostatic Hypotension
(OH).

Methods:

This single-center cross-sectional observational study encompassed 60 consecutive patients
that were hospitalized and recovered from severe or critical COVID-19. At the time of discharge,
Blood Pressure (BP) and Heart Rate (HR) in the supine and upright position (1st, 3rd, 5th and 10th
minutes) were measured. Symptomatic patients were reevaluated 2 months later.

Results:

The mean age of patients was 56.6 (± 16.2) years and 42 patients were male (70%). The most
frequent cardiovascular risk factor was hypertension (35%). OH and POTS were detected in 29(48.3%)
and 10(16.7%) patients, respectively, at the time of hospital discharge. The mean age of patients with
OH was higher than POTS and POTS was frequent in the elderly. Two months later, among 10 patients
with POTS, the sign and symptoms were resolved in 8(80%). Two (20%) patients who still had positive
signs and symptoms of POTS were older than 65 years. Among 29 patients with OH, the signs and
symptoms were resolved in 26 (89.7%).

Conclusion:

In our study, 65% of patients had OH or POTs on the day of hospital discharge; complete
recovery is gradual and needs several additional weeks. This is one of the aspects of the entity recently
named “Long COVID”.
Cellulose Nanomaterials Based Flexible Electrodes for All-Solid-State Supercapacitors
Authors: Gao Mengge , Du Haishun
Published: June 2022

In recent years, flexible all-solid-state supercapacitors have been widely used as the energy storage devices for various smart and wearable electronic devices. However, the design and fabrication of high-performance flexible supercapacitor electrodes is still challenging since most of the active materials used for supercapacitor electrodes lack the ability to form flexible and mechanically stable structures. Recently, cellulose nanomaterials (mainly include cellulose nanocrystals and cellulose nanofibrils) have gained extensive interests due to their large specific surface areas, versatile surface chemistry, high mechanical strength, and the ability to form mechanically stable structures (e.g., films, aerogels). These days, the design of flexible supercapacitor electrodes by combining cellulose nanomaterials with different active materials gradually attracted the attention of scholars. The main objective of this review is to give an overview of recent developments in the preparation of cellulose nanomaterials based flexible all-solid-state supercapacitor electrodes. The fabrication approach, structure characterization, and electrochemical performance of the invented cellulose nanomaterials based flexible supercapacitor are elaborated. Also, the current challenges and future outlook for the design and fabrication of cellulose nanomaterials based flexible all-solid-state supercapacitor are proposed.
Fats of Pigs of Different Breeds and Chemical Composition in the Diet of
Animals
Authors: Bekenev Vitaly A. , Mager Sergey N. , Arishin Anatoly A. , Merzlyakova Olga G. , Kashtanova Elena V. , Polonskaya Yana V. , Chegodaev Victor G. , Frolova Valentina I. , Bolshakova Izolda V. , Frolova Yulia V. , Ites Yuri V.
Published: June 2022

Background:

The studies were carried out on quails, in the feed of which fat of various
compositions was added.

Objective:

To establish the effect of adding fat from pigs of different breeds and vegetable oil to quail
feed on their growth, productivity, and characteristics of lipid metabolism.

Methods:

Three groups of 60 chickens each were fed with vegetable oil (control) and fat of two pig
breeds sharply differing in the chemical composition of fat - Kemerovo (К) and Pietrain (P) up to 23
weeks of age (3.0 - 3.5% of the mass of the diet). At 8 and 23 weeks of age, 10 individuals from each
group underwent biochemical blood tests.

Results:

The most rapid growth was observed in quails fed with K-breed fat. The level of total cholesterol
(TC) during the period of the experiment in quails significantly decreased, including those receiving vegetable
oil - by 1.49 times, fat of the K breed - by 1.58 times, fat breed P - 1.32 times. The atherogenic index (AI)
turned out to be significantly higher (Р<0.01) in quails that received fat of the P breed, containing a high level
of TС and rich in PUFA (0.93 conventional units against 0.69 in birds that received fat of the K breed and
0.57 - in the control group).

Conclusion:

The obtained data indicate that fat of breed K is more useful for animal nutrition and
maybe a priority in human nutrition.
Versatile Applications of Nanotechnology-based Electronic Nose
Authors: Girigoswami Koyeli , Shwetha M  , Girigoswami Agnishwar , Deepika B  , Gopikrishna A
Published: June 2022

Background:

Electronic noses have recently developed as a part of nanotechnology-based devices to cater to different needs in the field of biomedical sciences.

Objective:

To have a detailed idea regarding the various uses of electronic noses in the early detection of diseases, food spoilage, etc., we need to explore multiple studies.

Methods:

Chiefly, biosensors for detecting different volatile organic compounds responsible for different diseases exerted from the lungs are developed based on electronic noses. The difference in the breath pattern of normal individuals and diseased individuals who have cancer, CVD, diabetes, neurological disorders, etc. can be differentiated using the electronic nose.

Results:

In the field of food industry, bacterial contamination and other kinds of food spoilage can be detected at an early stage by detecting the pattern of evolved gases from these food items using the electronic nose.

Conclusion:

Thus, there are versatile applications of electronic noses in the early diagnosis of life-threatening diseases, chemical industry, food industries, etc., which will be discussed in this review.
A Variant Genetic Algorithm for a Specific Examination Timetabling
Problem in a Japanese University
Authors: Li Jiawei , Gonsalves Tad
Published: June 2022

Background:

Examination Timetabling Problem which tries to find an optimal examination schedule for schools, colleges, and universities, is a well-known NP-hard problem. This paper presents a Genetic Algorithm variant approach to solve a specific examination timetabling problem common in Japanese colleges and universities.

Methods:

The proposed algorithm uses direct chromosome representation Genetic Algorithm and implements constraint-based initialization and constraint-based crossover operations to satisfy the hard and soft constraints. An Island model with varying crossover and mutation probabilities and an improvement approach called pre-training are applied to the algorithm to further improve the result quality.

Results:

The proposed model is tested on synthetic as well as real datasets obtained from Sophia University, Japan and shows acceptable results. The algorithm was fine-tuned with different penalty points combinations and improvement combinations.

Conclusion:

The comparison results support the idea that the initial population pre-training and the island model are effective approaches to improve the result quality of the proposed model. Although the current island model used only four islands, incorporating greater number of islands, and some other diversity maintenance approaches such as memetic structures are expected to further improve the diversity and the result quality of the proposed algorithm on large scale problems.
Design, Synthesis, Anti-microbial and Molecular Docking Studies
of Novel 5-Pyrazyl-2-Sulfanyl-1, 3, 4-Oxadiazole Derivatives
Authors: Das Rina , Mehta Dinesh Kumar , Gupta Sumeet , Dhanawat Meenakshi
Published: June 2022

Background:

Chemical modification of Oxadiazole may lead to a potent therapeutic
agent. A series of novel 5-pyrazyl-2-sulfanyl-1, 3, 4-oxadiazole derivatives (5ag)
have been synthesised utilising pyrazinoic acid as a precursor. The new oxadiazole
compounds were docked against potential targets and evaluated for antibacterial and antitubercular
activity.

Method:

The 5-pyrazyl-2-substituted sulfanyl-1, 3,4-oxadiazole derivatives (5a-g) were
synthesized from the crucial intermediate 2-sulfanyl-5-pyrazyl-1, 3,4-oxadiazole (4),
which was prepared by treating the 2-pyrazyl hydrazide with CS2 and pyridine. IR,
1HNMR, 13C, MS and elemental analyses were used to confirm the chemical structures.

Results:

Antimicrobial activity was determined for each synthesized compound. Additionally,
compounds were evaluated for antitubercular activity against the Mycobacterium
Tuberculosis H37Rv strain. Compounds 5c, 5g, and 5a had a favourable antibacterial
profile, while 5c and 5g (MIC = 25 g/ml) demonstrated potential antitubercular activity
when compared to the other produced compounds. Molecular docking experiments
using V-Life Science MDS 4.6 supplemented the biological data.

Conclusion:

Each compound has been tested for antibacterial and antitubercular action
against a variety of microorganism strains and exhibits considerable activity. Additionally,
molecular docking analysis confirmed the experimental results by describing improved
interaction patterns.
A Study on the Bio-responses of a Freshwater Snail (Biomphalaria
alexandrina) to Fungal-derived Compounds
Authors: Mekawey Amal A.I. , Salah Ahmed M. , Yosri Mohammed
Published: June 2022

Background:

Biomphalaria alexandrina snails, as transitional hosts of schistosomiasis,
plays an essential part in the spread of the illness. Control of these snails by
the substance molluscicides antagonistically influences the oceanic climate, causing poisonous
and cancer-causing consequences for non-target life forms.

Objective:

Looking for new naturally safe substances that can treat schistosomiasis disease
with minimal side effects on the environment and plants, fish wealth and do not affect
vital human functions.

Methods:

Fifty fungal species were used to evaluate their activity against Biomphalaria
alexandrina. Study the effect of the fungal extract on vital functions of Biomphalaria
alexandrina and fish wealth. Purification of active substances and identification of their
chemical structures.

Results:

Cladosporium nigrellum and Penicillium aurantiogresium metabolites were effective
against B. alexandrina snails, and the effects of promising fungal extracts sublethal
concentrations (IC10 & IC25) on the levels of steroid sex hormones, liver enzymes,
total protein, lipids, albumin and glucose were determined. Chemical analyses of this filtrate
separated a compound effective against snails; it was identified. Protein electrophoresis
showed that fungal filtrate affects the protein pattern of snails’ haemolymph. Little
or no mortality of Daphnia pulex individuals was observed after their exposure to sublethal
concentrations of each treatment.

Conclusion:

Certain compounds from fungal cultures could be safely used for biological
control of Biomphalaria alexandrina snails.
Biological Importance and Therapeutic Benefit of Rhamnocitrin:
A Review of Pharmacology and Analytical Aspects
Authors: Patel Dinesh Kumar
Published: June 2022

Background:

Humans have a long history of the uses of plant based products, including
extracts and pure phytoconstituents for the treatment of human diseases in the different system of
medicine. In the developing countries, phytoproducts play an important role in the healthcare systems
due to their medicinal importance and pharmacological activities. Flavonoids class phytochemicals
are beneficial for human beings because of their free radical scavenging properties and
trace metals chelating potential. Flavonoids have inhibitory potential for the growth of bacteria and
virus mainly through enzyme inhibition functions and viral translation. Rhamnocitrin is also called
7- methyl-kaempferol is important flavonoids, which has been isolated from different medicinal
plants and has pharmacological activities in the medicine.

Methods:

Present paper describes the biological potential and health beneficial aspects of rhamnocitrin
in the medicine through the data analysis of published papers in the recent years in the
field of medicine and modern medical sciences. Scientific data on rhamnocitrin have been collected
from electronic databases such as PubMed, Google Scholar, Google, Scopus and Science Direct
in the present investigation and analyzed to know the biological importance and pharmacological
activities of rhamnocitrin. Pharmacological scientific data of rhamnocitrin have been collected and
analyzed in the present work with their analytical aspects.

Results:

Literature data analysis of different scientific work on rhamnocitrin revealed the biological
importance of rhamnocitrin in medicine. Rhamnocitrin is known to be a promising phytoconstituents
found to be present in medicinal plants with a wide range of biological activities. Rhamnocitrin
was found to have pharmacological activities, including anti-atherogenic, anti-oxidant,
anti-cancer, anti-bacterial, anti-inflammatory, enzymatic and neuroprotective potential. Further
biological effect of rhamnocitrin on adipocyte differentiation has been also studied in the present
work. Analytical data on rhamnocitrin signified the application of different analytical techniques
for the separation, isolation and identification of rhamnocitrin in medicine.

Conclusion:

Literature data analysis of different scientific research works revealed the biological
importance and therapeutic benefit of rhamnocitrin in medicine.
Leadership style and personnel performance
Authors: Fajar Rheza Kurnia
Published: June 2022

This article mainly discusses the relationship between leadership style and employee performance. Research on the relationship between leadership style and employee performance still shows mixed results. The purpose of this study was to determine the relationship between leadership style and employee performance by comparing the results of primary research on these two variables. The method used is a conceptual analysis of various previous studies in the last ten years. The results show that there is a significant and positive relationship between leadership style and employee performance, especially in the Indonesian context where social relations take priority in society. This implies that managers must be able to create a favorable leadership style to encourage employee performance improvement, although this is not the only thing that must be considered.
Wisdom of the Experts Versus Opinions of the Crowd in Hospital Quality Ratings: Analysis of Hospital Compare Star Ratings and Google Star Ratings
Authors: Ramasubramanian Hari , Joshi Satish , Krishnan Ranjani
Published: June 2022

Background

Popular web-based portals provide free and convenient access to user-generated hospital quality reviews. The Centers for Medicare & Medicaid Services (CMS) also publishes Hospital Compare Star Ratings (HCSR), a comprehensive expert rating of US hospital quality that aggregates multiple measures of quality. CMS revised the HCSR methods in 2021. It is important to analyze the degree to which web-based ratings reflect expert measures of hospital quality because easily accessible, crowdsourced hospital ratings influence consumers’ hospital choices.

Objective

This study aims to assess the association between web-based, Google hospital quality ratings that reflect the opinions of the crowd and HCSR representing the wisdom of the experts, as well as the changes in these associations following the 2021 revision of the CMS rating system.

Methods

We extracted Google star ratings using the Application Programming Interface in June 2020. The HCSR data of April 2020 (before the revision of HCSR methodology) and April 2021 (after the revision of HCSR methodology) were obtained from the CMS Hospital Compare website. We also extracted scores for the individual components of hospital quality for each of the hospitals in our sample using the code provided by Hospital Compare. Fractional response models were used to estimate the association between Google star ratings and HCSR as well as individual components of quality (n=2619).

Results

The Google star ratings are statistically associated with HCSR (P<.001) after controlling for hospital-level effects; however, they are not associated with clinical components of HCSR that require medical expertise for evaluation such as safety of care (P=.30) or readmission (P=.52). The revised CMS rating system ameliorates previous partial inconsistencies in the association between Google star ratings and quality component scores of HCSR.

Conclusions

Crowdsourced Google star hospital ratings are informative regarding expert CMS overall hospital quality ratings and individual quality components that are easier for patients to evaluate. Improvements in hospital quality metrics that require expertise to assess, such as safety of care and readmission, may not lead to improved Google star ratings. Hospitals can benefit from using crowdsourced ratings as timely and easily available indicators of their quality performance while recognizing their limitations and biases.
Possible Contribution of Meaning in Life in Patients With Chronic Pain and Suicidal Ideation: Observational Study
Authors: Chytas Vasileios , Costanza Alessandra , Mazzola Viridiana , Luthy Christophe , Galani Vasiliki , Bondolfi Guido , Cedraschi Christine
Published: June 2022

Background

Chronic pain is associated with an elevated risk of suicidal ideation (SI).

Objective

We aimed to examine if the presence or the search for Meaning in Life (MiL) are associated with less SI and explore whether MiL profiles emerge in our cohort. These profiles can be described as high presence–high search, high presence–low search, low presence–low search, and low presence–high search.

Methods

In this observational study, we recruited 70 patients who were referred to the Multidisciplinary Pain Center of the Geneva University Hospitals and who answered positively to question 9 on the Beck Depression Inventory, 2nd Edition, investigating SI. Patients who agreed to participate in the study were further investigated; they participated in a structured diagnostic interview to screen for psychiatric diagnoses. During this interview, they completed the Meaning in Life Questionnaire and the semistructured Scale for Suicide Ideation (SSI) to assess the characteristics and severity of SI.

Results

There was a statistically significant correlation between the presence of MiL subscale and the SSI. These 2 scales had a negative and statistically highly significant correlation (R=–.667; P<.001). The results also showed a negative and statistically highly significant correlation between the score of the search for MiL and the SSI (R=–.456; P<.001). The results thus pointed to the presence of MiL as a potential protective factor against the severity of SI, while the search for MiL is also a possible resiliency factor, although to a lesser extent. The profile low presence–low search grouped the vast majority (47%) of the patients; in these patients, the mean SSI score was 14.36 (SD 5.86), much higher compared with that of the other subgroups.

Conclusions

This study’s results point to MiL as a concept of interest regarding devising psychotherapeutic interventions for chronic pain patients in order to reduce the suicidal risk and more accurately determine patients’ suffering.
Burnout and Associated Psychological Problems Among Teachers and the Impact of the Wellness4Teachers Supportive Text Messaging Program: Protocol for a Cross-sectional and Program Evaluation Study
Authors: Agyapong Belinda , Wei Yifeng , da Luz Dias Raquel , Agyapong Vincent Israel Opoku
Published: June 2022

Background

Stress, burnout, anxiety, and depression continue to be a problem among teachers worldwide. It is not presently known what the prevalence and correlates for these psychological problems are among teachers in Alberta and Nova Scotia. It is also not known if a supportive text message program (Wellness4Teachers) would be effective in reducing stress, burnout, anxiety, or depression symptoms among teachers.

Objective

The goal of this study is to evaluate the prevalence and correlates of stress, burnout, symptoms of anxiety, depression, and low resilience among elementary and high school teachers in Alberta and Nova Scotia, Canada. It also aims to determine if daily supportive text messages can help reduce the prevalence of these psychological problems in teachers.

Methods

This is a cross-sessional mixed methods study with data to be collected from subscribers of Wellness4Teachers using a web-based survey at baseline (onset of text messaging), 6 weeks, the program’s midpoint (3 months), and end point (6 months). Teachers can subscribe to the Wellness4Teachers program by texting the keyword “TeachWell” to the program phone number. Outcome measures will be assessed using standardized rating scales and key informant interviews. Data will be analyzed with descriptive and inferential statistics using SPSS and thematic analysis using NVivo.

Results

The results of this study are expected 24 months after program launch. It is expected that the prevalence of stress, burnout, anxiety, depression, and low resilience among teachers in Alberta and Nova Scotia would be comparable to those reported in other jurisdictions. It is also expected that factors such as gender, number of years teaching, grade of teaching, and school type (elementary vs high school) will have an association with burnout and other psychological disorders among teachers. Furthermore, it is expected that Wellness4Teachers will reduce the prevalence and severity of psychological problems in teachers, and subscriber satisfaction will be high.

Conclusions

The Wellness4Teachers project will provide key information regarding prevalence and correlates of common mental health conditions in teachers in Alberta and Nova Scotia, as well as the impact of daily supportive text messages on these mental health parameters. Information from this study will be useful for informing policy and decision-making concerning psychological interventions for schoolteachers.
Possible Contribution of Meaning in Life in Patients With Chronic Pain and Suicidal Ideation: Observational Study (Preprint)
Authors: Chytas Vasileios , Costanza Alessandra , Mazzola Viridiana , Luthy Christophe , Galani Vasiliki , Bondolfi Guido , Cedraschi Christine
Published: June 2022

BACKGROUND

Chronic pain is associated with an elevated risk of suicidal ideation (SI).

OBJECTIVE

We aimed to examine if the presence or the search for Meaning in Life (MiL) are associated with less SI and explore whether MiL profiles emerge in our cohort. These profiles can be described as high presence–high search, high presence–low search, low presence–low search, and low presence–high search.

METHODS

In this observational study, we recruited 70 patients who were referred to the Multidisciplinary Pain Center of the Geneva University Hospitals and who answered positively to question 9 on the Beck Depression Inventory, 2nd Edition, investigating SI. Patients who agreed to participate in the study were further investigated; they participated in a structured diagnostic interview to screen for psychiatric diagnoses. During this interview, they completed the Meaning in Life Questionnaire and the semistructured Scale for Suicide Ideation (SSI) to assess the characteristics and severity of SI.

RESULTS

There was a statistically significant correlation between the presence of MiL subscale and the SSI. These 2 scales had a negative and statistically highly significant correlation (R=–.667; P<.001). The results also showed a negative and statistically highly significant correlation between the score of the search for MiL and the SSI (R=–.456; P<.001). The results thus pointed to the presence of MiL as a potential protective factor against the severity of SI, while the search for MiL is also a possible resiliency factor, although to a lesser extent. The profile low presence–low search grouped the vast majority (47%) of the patients; in these patients, the mean SSI score was 14.36 (SD 5.86), much higher compared with that of the other subgroups.

CONCLUSIONS

This study’s results point to MiL as a concept of interest regarding devising psychotherapeutic interventions for chronic pain patients in order to reduce the suicidal risk and more accurately determine patients’ suffering.
Phytochemical Screening of Ricinus communis and Erigeron bonariensis
Authors: D. Wadankar Gajanan , S. Khanzode Manasi , K. Mahale Bhagyashri , P. Gavhale Anjali
Published: June 2022

Ricinus communis and Erigeron bonariensis were selected and aimed to investigate the presence of phytochemicals in leaf and stem. Aqueous, Acetone and Methanol Solvents were used for phytochemical analysis. Our findings provides evidence, that aqueous and organic solvent extracts of these plants contain medicinally important bioactive compounds.
Assessoria e Assistência Técnica para Habitação de Interesse Social: do discurso à construção da prática profissional
Authors: Cardoso Fernanda Simon , Lopes João Marcos de Almeida
Published: June 2022

Neste artigo, é proposto um diálogo entre as noções de Assessoria e Assistência Técnica para Habitação de Interesse Social (ATHIS), partindo de um ponto em comum: a atividade de arquitetos e urbanistas. São comentados o histórico de ações voltadas a essa área e as recentes discussões e atividades realizadas após a aprovação da Lei nº 11.888/2008, promovidas sobretudo por entidades representativas desses profissionais. Tal diálogo, acreditamos, poderia fomentar a construção de um novo ideário profissional e uma agenda capaz de delimitar mais claramente o que poderia se constituir como campo de atuação dos profissionais dedicados à ATHIS. Desde a sanção da referida lei, há certa efervescência de debates entre arquitetos e urbanistas sobre o assunto, mas sem um consenso sedimentado sobre qual deve ser o formato técnico e político das ações. Enquanto seguem as disputas em torno do tema, a falta de clareza abre brechas para o surgimento de propostas controversas e discussões que não contribuem para introduzir mudanças estruturais na forma de assessorar ou mesmo de produzir a moradia popular.
The Classification of Clifford Gates over Qubits
Authors: Grier Daniel , Schaeffer Luke
Published: June 2022

We examine the following problem: given a collection of Clifford gates, describe the set of unitaries generated by circuits composed of those gates. Specifically, we allow the standard circuit operations of composition and tensor product, as well as ancillary workspace qubits as long as they start and end in states uncorrelated with the input, which rule out common "magic state injection" techniques that make Clifford circuits universal. We show that there are exactly 57 classes of Clifford unitaries and present a full classification characterizing the gate sets which generate them. This is the first attempt at a quantum extension of the classification of reversible classical gates introduced by Aaronson et al., another part of an ambitious program to classify all quantum gate sets.
The classification uses, at its center, a reinterpretation of the tableau representation of Clifford gates to give circuit decompositions, from which elementary generators can easily be extracted. The 57 different classes are generated in this way, 30 of which arise from the single-qubit subgroups of the Clifford group. At a high level, the remaining classes are arranged according to the bases they preserve. For instance, the CNOT gate preserves the X and Z bases because it maps X-basis elements to X-basis elements and Z-basis elements to Z-basis elements. The remaining classes are characterized by more subtle tableau invariants; for instance, the T_4 and phase gate generate a proper subclass of Z-preserving gates.
Tecnologias de cuidados neuropaliativos à criança e ao adolescente: perspectivas de profissionais da enfermagem
Authors: Andrade Luciano Geremias , Migoto Michelle Thais
Published: June 2022

Care technologies addressed during palliative care should be aimed at promoting the quality of life of children and adolescents. To describe the applications of assistive technologies available in the care of children and adolescents in the neuropalliative context. A mixed study was carried out, with online data collection with nursing professionals. The technologies analyzed were: Music therapy, massage, use of animals, therapeutic toys, auriculotherapy, physical exercises, media devices and family participation. A descriptive analysis was carried out to detect which techniques were used in the terminal context of children and teenagers, consequently the effect generated on the patient. After this mapping, the result was the use of the family (24; 80.0%), followed by the therapeutic toy (17; 56.7%), as the main technologies used. Finally, it became clear that distraction instruments attached to childhood and the feeling of home are the most used and with positive results in pediatric patients.
EFEKTIFITAS COMBO ACCUPRESSURE POINT PADA FASE MENSTRUASI TERHADAP DISMINORE PADA REMAJA
Authors: Hasanah Oswati , Lestari Widia , Novayelinda Riri , Deli Hellena
Published: June 2022

Dysmenorrhea is a problem that is often occur among adolescent girls during menstruation. Dysmenorrhea in adolescents can cause impact to academic and daily activities, which in turn may have an impact on adolescent quality of life in the future. The purpose of this study was to determine the effectiveness of acupressure therapy at 3 points on the intensity of dysmenorrhea in adolescents. This research is a quantitative research, using a randomized clinical trial design. The study was conducted in Pekanbaru with the population were all female students of the Faculty of Nursing, at Riau University. A sample of 30 respondents divided into experimental group and the control group were selected based on inclusion and exclusion criteria. The measuring instrument used in this study consists of 2 parts. The first part is a structured questionnaire and the second part is the Visual Analogue Scale (VAS). The result shows, based on the age of most respondents were aged 18-19 years (53%). Based on ethnicity, most respondents have Malay ethnicity (43, 3%). Based on the results of the bivariate test analysis in both groups, combination acupressure at LR3, LI4 and Yintang points did not affect the decrease in pain intensity of dysmenorrhea if it was done in the menstrual phase (p-value> α), but there were significant differences in pain intensity before and after the intervention in the experimental and control group (p-value> α), which is 3.13 points in the experimental group when compared to the control group which is 2.53 points. The results of this study can recommend the use of acupressure as a nursing intervention or as an independent intervention for adolescents to overcome dysmenorrhea.
Hubungan Tingkat Stres dengan Kualitas Tidur pada Mahasiswa Tingkat Akhir di Fakultas Kedokteran dan Ilmu Kesehatan Universitas Jambi
Authors: Clariska Windi , Yuliana Yuliana , Kamariyah Kamariyah
Published: June 2022

Internal and external obstacles that occur in final year students can cause students to be depressed and stressed and have an impact on the quality of their sleep. The results of the preliminary survey on 23 students found it difficult to rest since their thesis writing. WHO data for 2019, nearly 264 million people in the world experience stress and depression. To determine the relationship  between stress levels and sleep quality in final year students at the Faculty of Medicine and Health Sciences, Jambi University. This research is a quantitative descriptive study on 92 samples of final year students at the Faculty of Medicine and Health Sciences, Jambi University using the method cluster random sampling. This study uses primary data obtained from questionnaires and data analysis using the Spearman rank test with p value = 0.05. 23 respondents (25%) experienced mild stress, 21 respondents (22.8%) moderate stress, 22 respondents (23.9%) severe stress and 5 very severe stress (5.4%). Poor sleep quality amounted to 84 respondents (91.3%) while good amounted to 8 respondents (8.7%). From the results of the Spearman Rank analysis, it was obtained a p-value of 0.030 with a closeness of the relationship of 0.227. There is a significant relationship between stress levels and sleep quality in final year students at the Faculty of Medicine and Health Sciences, Jambi University.
Keywords: stress, sleep quality, student.
 
Abstrak
Hambatan internal dan eksternal yang terjadi pada mahasiswa tingkat akhir dapat menyebabkan mahasiswa tertekan dan stres serta berakibat pada kualitas tidurnya. Hasil survey pendahuluan pada 23 mahasiswa, merasa sulit beristirahat semenjak menjalani pembuatan skripsi. Data WHO tahun 2019 hampir 264 juta penduduk dunia mengalami stres dan depresi. Tujuan dari penelitian ini adalah mengetahui hubungan tingkat stres dengan kualitas tidur pada Mahasiswa tingkat akhir di Fakultas Kedokteran dan Ilmu Kesehatan Universitas Jambi. Penelitian ini merupakan penelitian deskriptif kuantitatif pada 92 sampel mahasiswa tingkat akhir di Fakultas Kedokteran dan Ilmu Kesehatan Universitas Jambi dengan metode cluster random sampling. Penelitian ini menggunakan data primer yang diperoleh dari kuesioner dan analisa data menggunakan uji spearman rank dengan p-value = 0,05. Didapatkan mahasiswa yang mengalami tingkat stres ringan 23 responden (25%), stres sedang 21 responden (22,8%), stres berat 22 responden (23,9%) dan stres sangat berat 5 responden (5,4%). Kualitas tidur buruk berjumlah 84 responden (91,3%) sedangkan baik berjumlah 8 responden (8,7%). Dari hasil analisis Spearman Rank didapatkan p-value 0,030 dengan keeratan hubungan 0,227. Terdapat hubungan yang bermakna antara tingkat stres dengan kualitas tidur pada mahasiswa tingkat akhir di Fakultas Kedokteran dan Ilmu Kesehatan Universitas Jambi.
Kata Kunci: Stres, Kualitas tidur, Mahasiswa.
Gambaran Tingkat Pendidikan dan Tinggi Badan Orangtua Balita Stunting Usia 24-59 Bulan
Authors: Putri Nelvi , Nurlinawati Nurlinawati , Mawarti Indah
Published: June 2022

Stunting has a large impact on the growth and development of children and also the economy of  Indonesia in  the  future.  Stunted toddlers will  generally  experience obstacles in cognitive and motor development and also have a greater risk for suffering from non- communicable diseases such as diabetes, obesity, and heart disease in adulthood. Parent's level of education and height are the main determinants of stunting. Therefore, the researcher wants to see an overview of the level of education and stunting of parents of stunting toddlers aged 24-59 months in the working area of the Puskesmas Siulak Mukai, Kerinci Regency. This type of research is descriptive research. In determining the number of samples in this study using a total sampling technique that is all parents who have stunting toddlers aged 24-59 months in the working area of the Puskesmas Siulak Mukai Kabupaten Kerinci used as samples with a total sample of 42 stunting toddlers, sampling using the purposive sampling method. Analysis of the data used in this study is univariate analysis. The  results  showed  that  the  level  of  education  of  high  school fathers  / equivalent was 42.9%, the level of education of high school / fathers as much as 40.5%, father's height was 55% more than the height of short fathers by 45%, high short maternal body as much as 59.5%. The level of education of parents of high school / equivalent and low maternal height can cause children to grow stunting.