bluuebunny/crossref_metadata_2025 huggingface dataset:
Stability Analysis of the Rotor-Journal Bearing System Considering Shear and Gaseous Cavitation
Authors: Sun Lin , Shi Jianchao , Jiang Tao , Li Zhen , Xie Quntao , Liu Zhaozeng , Xu Weiwei
Published: February 2024

Part of the gas phase within the bearing emanates from the gaseous lubricating medium generated by the phase transition of the liquid lubricant under low pressure, while the remaining portion originates from the expansion of gases, such as air, present in the lubricant. This study delves into the impact of vapor and gas cavitation on the stability of the rotor-journal bearing system. Utilizing computational fluid dynamics (CFD), a 3D transient lubrication model is developed for the rotor-journal bearing system. This model integrates a combined cavitation approach, encompassing both vaporous and gaseous cavitation phenomena. Based on a new structured dynamic mesh method, the journal orbits are obtained when the journal moves in the rotor-journal bearing system. In vaporous and gaseous cavitation, shear stress and non-condensable gases (NCG) are incorporated successively. Compared with the combined cavitation model, the basic cavitation model journal orbit amplitude is significantly larger than the combined cavitation model. The carrying capacity of journal bearings under the basic cavitation model is overestimated, leading to a more conservative prediction for system stability.
Biochar as Alternative Material for Heavy Metal Adsorption from Groundwaters: Lab-Scale (Column) Experiment Review
Authors: Viotti Paolo , Marzeddu Simone , Antonucci Angela , Décima María Alejandra , Lovascio Pietro , Tatti Fabio , Boni Maria Rosaria
Published: February 2024

The purpose of this manuscript is to present a review of laboratory experiments (including methodology and results) that use biochar, a specific carbon obtained by a pyrolysis process from different feedstocks, as an alternative material for heavy metal adsorption from groundwater. In recent years, many studies have been conducted regarding the application of innovative materials to water decontamination to develop a more sustainable approach to remediation processes. The use of biochar for groundwater remediation has particularly attracted the interest of researchers because it permits the reuse of materials that would be otherwise disposed of, in accordance with circular economy, and reduces the generation of greenhouse gases if compared to the use of virgin materials. A review of the different approaches and results reported in the current literature could be useful because when applying remediation technologies at the field scale, a preliminary phase in which the suitability of the adsorbent is evaluated at the lab scale is often necessary. This paper is therefore organised with a short description of the involved metals and of the biochar production and composition. A comprehensive analysis of the current knowledge related to the use of biochar in groundwater remediation at the laboratory scale to obtain the characteristic parameters of the process that are necessary for the upscaling of the technology at the field scale is also presented. An overview of the results achieved using different experimental conditions, such as the chemical properties and dosage of biochar as well as heavy metal concentrations with their different values of pH, is reported. At the end, numerical studies useful for the interpretation of the experiment results are introduced.
Effect of Bi on the Performance of Al-Ga-In Sacrificial Anodes
Authors: Liu Xin , Lin Yufeng , Li Yu , Liu Nian
Published: February 2024

Cathodic protection is widely used for metal corrosion protection. To improve their performance, it is necessary and urgent to study the influence of metal oxides on the microstructure and performance of aluminum alloy sacrificial anodes. Taking an Al-Ga-In sacrificial anode as the research object, the dissolution morphology and current efficiency characteristics were studied by means of electrochemical testing and microstructural observation, and the influence of varying Pb and Bi contents on the performance of an aluminum alloy sacrificial anode was investigated. The test results reveal that: (1) The Al-Ga-In sacrificial anode with 4% Pb and 1% Bi contents exhibits the best sacrificial anode performance. (2) The inclusion of an appropriate Bi element content shifts the open-circuit potential in a negative direction and promotes activation dissolution. Conversely, excessive Bi content leads to uneven dissolution, resulting in the shedding of anode grains and greatly reducing the current efficiency. (3) During the activation dissolution of the aluminum alloy, the second phase preferentially dissolves, and the activation point destroys the oxide film, resulting in the dissolution of the exposed aluminum matrix. Consequently, the concentration of dissolved metal ions is reduced and deposited back on the surface of the anode sample, promoting the continuous dissolution of the anode.
Microstructure and Friction Properties of AlCrTiVNbx High-Entropy Alloys via Annealing Manufactured by Vacuum Arc Melting
Authors: Li Baowei , Zhang Zihao , Luo Xiaoling , Chen Kangmin , Zhang Jiaqi , Gong Pan , Peng Zhen
Published: February 2024

To enhance the friction and wear properties of alloys, AlCrTiVNbx high-entropy alloys (HEAs) with various Nb contents were prepared using the arc melting technique and then annealed at 1000 °C for 2 h. The microstructure and hardness changes in the AlCrTiVNbx (x = 0.3, 0.4, and 0.5) HEAs after casting and annealing were studied via scanning electron microscopy, X-ray diffractometry, optical microscopy and the Vickers hardness test. The MFT-EC400 ball disc reciprocating friction and wear tester was used to investigate the wear resistance of the HEAs before and after annealing. The results show that the annealed AlCrTiVNbx HEAs changed from a single-phase structure to a multi-phase structure, and the content of the face-center cubic (FCC) phase and hexagonal close-packed (HCP) phase further increases with the increase in Nb content. The hardness value of the annealed HEAs is greatly enhanced compared with the casting state, and the hardness of the Nb0.5 HEA is increased from 543 HV to 725 HV after annealing. The wear resistance of the alloys after the annealing treatment is also greatly improved, among which Nb0.5 has the best wear resistance. The average friction coefficient of Nb0.5 is 0.154 and the wear rate is 2.117 × 10−5 mm3/(N·m). We believe that the precipitation strengthening after the annealing treatment and the lubrication effect of the FCC phase are the reasons for the significant improvement in wear resistance. The morphology of the samples indicates that the wear mechanism of the alloy includes adhesive wear, abrasive wear and a certain degree of oxidation wear.
Experiment and Simulation Study on the Cooling Performance of Oil-Cooling PMSM with Hairpin Winding
Authors: Yang Chen , Cai Wei , Xie Ying , Shao Baicheng
Published: February 2024

In this paper, the cooling performance of oil-cooling PMSM with hairpin winding under various oil parameters is analyzed via a simulation and an experiment. The effects of oil jet positions, oil temperatures, and oil flow rates on the cooling performance are analyzed. It is found that increasing the oil temperature in the range of 20 °C to 60 °C, increasing the flow rate of oil jets whose position angle is from 15° to 45°, and increasing the flow rate in the range of 1 L/min to 2 L/min will significantly improve the cooling performance. The apertures of the oil spray ring are optimized using the Taguchi algorithm. The cooling performance is the best when the flow ratio is m(0°):m(15°):m(30°):m(45°):m(60°):m(75°) = 4%:19%:10%:10%:4%:4%. This study provides a guide for the design of the oil-cooling system for the hairpin winding of the PMSM.
Roles of a Glycolipid MPIase in Sec-Independent Membrane Protein Insertion
Authors: Nomura Kaoru , Mori Shoko , Shimamoto Keiko
Published: February 2024

Membrane protein integrase (MPIase), an endogenous glycolipid in Escherichia coli (E. coli) membranes, is essential for membrane protein insertion in E. coli. We have examined Sec-independent membrane protein insertion mechanisms facilitated by MPIase using physicochemical analytical techniques, namely solid-state nuclear magnetic resonance, fluorescence measurements, and surface plasmon resonance. In this review, we outline the physicochemical characteristics of membranes that may affect membrane insertion of proteins. Subsequently, we introduce our results verifying the effects of membrane lipids on insertion and estimate the impact of MPIase. Although MPIase is a minor component of E. coli membranes, it regulates insertion by altering the physicochemical properties of the membrane. In addition, MPIase promotes insertion by interacting with substrate proteins. We propose comprehensive mechanisms for the membrane insertion of proteins involving MPIase, which provide a physicochemical basis for understanding the roles of glycolipids in protein translocation.
Identification of Sheet Metal Constitutive Parameters Using Metamodeling of the Biaxial Tensile Test on a Cruciform Specimen
Authors: Parreira Tomás G. , Marques Armando E. , Sakharova Nataliya A. , Prates Pedro A. , Pereira André F. G.
Published: February 2024

An identification strategy based on a machine learning approach is proposed to identify the constitutive parameters of metal sheets. The main novelty lies in the use of Gaussian Process Regression with the objective of identifying the constitutive parameters of metal sheets from the biaxial tensile test results on a cruciform specimen. The metamodel is intended to identify the constitutive parameters of the work hardening law and yield criterion. The metamodel used as input data the forces along both arms of the cruciform specimen and the strains measured for a given set of points. The identification strategy was tested for a wide range of virtual materials, and it was concluded that the strategy is able to identify the constitutive parameter with a relative error below to 1%. Afterwards, an uncertainty analysis is conducted by introducing noise to the force and strain measurements. The optimal strategy is able to identify the constitutive parameters with errors inferior to 6% in the description of the hardening, anisotropy coefficients and yield stresses in the presence of noise. The study emphasizes that the main strength of the proposed strategy relies on the judicious selection of critical areas for strain measurement, thereby increasing the accuracy and reliability of the identification process.
Kinetic Modeling of Brain [18-F]FDG Positron Emission Tomography Time Activity Curves with Input Function Recovery (IR) Method
Authors: Bucci Marco , Rebelos Eleni , Oikonen Vesa , Rinne Juha , Nummenmaa Lauri , Iozzo Patricia , Nuutila Pirjo
Published: February 2024

Accurate positron emission tomography (PET) data quantification relies on high-quality input plasma curves, but venous blood sampling may yield poor-quality data, jeopardizing modeling outcomes. In this study, we aimed to recover sub-optimal input functions by using information from the tail (5th–100th min) of curves obtained through the frequent sampling protocol and an input recovery (IR) model trained with reference curves of optimal shape. Initially, we included 170 plasma input curves from eight published studies with clamp [18F]-fluorodeoxyglucose PET exams. Model validation involved 78 brain PET studies for which compartmental model (CM) analysis was feasible (reference (ref) + training sets). Recovered curves were compared with original curves using area under curve (AUC), max peak standardized uptake value (maxSUV). CM parameters (ref + training sets) and fractional uptake rate (FUR) (all sets) were computed. Original and recovered curves from the ref set had comparable AUC (d = 0.02, not significant (NS)), maxSUV (d = 0.05, NS) and comparable brain CM results (NS). Recovered curves from the training set were different from the original according to maxSUV (d = 3) and biologically plausible according to the max theoretical K1 (53//56). Brain CM results were different in the training set (p < 0.05 for all CM parameters and brain regions) but not in the ref set. FUR showed reductions similarly in the recovered curves of the training and test sets compared to the original curves (p < 0.05 for all regions for both sets). The IR method successfully recovered the plasma inputs of poor quality, rescuing cases otherwise excluded from the kinetic modeling results. The validation approach proved useful and can be applied to different tracers and metabolic conditions.
Titanium Tetrachloride-Assisted Direct Esterification of Carboxylic Acids
Authors: Cavallaro Palmira Alessia , De Santo Marzia , Greco Marianna , Marinaro Rocco , Belsito Emilia Lucia , Liguori Angelo , Leggio Antonella
Published: February 2024

Ester compounds, widely found in pharmaceutical and natural products, play a crucial role in organic synthesis, prompting the development of numerous methods for their synthesis. An important chemical approach in synthesizing esters from carboxylic acids involves the activation of the carboxyl function, requiring the conversion of the hydroxyl group into a suitable leaving group. This paper presents the findings of our investigations into an efficient method for producing esters from carboxylic acids and alcohols, using the Lewis acid titanium tetrachloride. Titanium tetrachloride has proven highly effective as a coupling reagent for the one-pot formation of esters from carboxylic acids and alcohols operating under mild and neutral conditions. Notably, the reaction eliminates the need for bases, yielding carboxylic esters in high purity and yields. The method is efficient, even with long-chain carboxylic acids, and operates well with primary alcohols in dichloromethane. Steric hindrance, potentially present in carboxylic acids, has a moderate effect on the reaction. Alcohol substrates that easily form stable carbocations require, instead, the use of non-polar solvents like hexane for the reaction.
Hypolipidemic and Antithrombotic Effect of 6′-O-Caffeoylarbutin from Vaccinium dunalianum Based on Zebrafish Model, Network Pharmacology, and Molecular Docking
Authors: Wu Boxiao , Li Churan , Kan Huan , Zhang Yingjun , Rao Xiaoping , Liu Yun , Zhao Ping
Published: February 2024

Vaccinium dunalianum leaf buds make one of the most commonly used herbal teas of the Yi people in China, which is used to treat articular rheumatism, relax tendons, and stimulates blood circulation in the body. In addition, 6′-O-caffeoylarbutin (CA) is a standardized extract of V. dunalianum, which has been found in dried leaf buds, reaching levels of up to 31.76%. Because of the uncommon phenomenon, it is suggested that CA may have a potential therapeutic role in hyperlipidemia and thrombosis. This study was designed to study the efficacy of CA on treating hyperlipidemia and thrombosis and the possible mechanisms behind these effects. Hyperlipidemia and thrombosis zebrafish models were treated with CA to observe variations of the integrated optical density within the vessels and the intensity of erythrocyte staining within the hearts. The possible mechanisms were explored using network pharmacology and molecular docking. The results demonstrate that CA exhibits an excellent hypolipidemic effect on zebrafish at concentrations ranging from 3.0 to 30.0 μg/mL and shows thrombosis inhibitory activity in zebrafish at a concentration of 30.0 μg/mL, with an inhibition rate of 44%. Moreover, network pharmacological research shows that MMP9, RELA, MMP2, PRKCA, HSP90AA1, and APP are major targets of CA for therapy of hyperlipidemia and thrombosis, and may relate to pathways in cancer, chemical carcinogenesis-receptor activation, estrogen signaling pathway, and the AGE–RAGE signaling pathway in diabetic complications.
Nutritionally Valuable Components and Heat-Induced Contaminants in Extruded Snack Products Enriched with Defatted Press Cakes
Authors: Jozinović Antun , Panak Balentić Jelena , Ačkar Đurđica , Benšić Mirta , Babić Jurislav , Barišić Veronika , Lončarić Ante , Miličević Borislav , Šubarić Drago
Published: February 2024

This research studies the influence of the addition of defatted press cakes (from the production of hazelnut, camelina, pumpkin, and hemp seed oil) on nutritionally important components: fibre, resistant starch, polyphenols, hydroxymethylfurfural (HMF), and acrylamide in directly and indirectly expanded snacks. The amounts of press cakes added to corn grits were 3, 6, and 9%. Extrusion was carried out in a laboratory single-screw extruder. For indirectly expanded products (SCFX), supercritical CO2 was injected during extrusion, and secondary expansion was completed in the microwave oven. The type and content of press cake, as well as the type of product, significantly influenced total polyphenol content and antioxidant activity. Press cakes increased the contents of both soluble and insoluble fibre (from 1.94% d. m. and 1.28% d. m. for extrudates without press cakes up to 3.17% d. m. and 6.94% d. m. for SCFX extrudates with press cakes, respectively), and resistant starch was not markedly influenced by their addition. The influence of the content of press cake on HMF was not significant, whereas the type of cake and the type of extrusion influenced HMF significantly. In a raw mixture of corn grits with 3% of pumpkin press cake, HMF was below the limit of detection, and the highest content was found in the classically extruded sample with the addition of 9% of camelina press cake (580 ppb). In all samples, the acrylamide content was below the limit of detection, indicating that safe products were obtained. This research shows potential for the implementation of supercritical CO2 extrusion in the production of safe, nutritionally improved snack products. Future research might bring about the design of cost-effective processes applicable in the industry.
Non-Interventional Weight Changes Are Associated with Alterations in Lipid Profiles and in the Triglyceride-to-HDL Cholesterol Ratio
Authors: Weinstein Shiri , Maor Elad , Kaplan Alon , Hod Tammy , Leibowitz Avshalom , Grossman Ehud , Shlomai Gadi
Published: February 2024

Background: Obesity is associated with dyslipidemia, and weight loss can improve obese patients’ lipid profile. Here, we assessed whether non-interventional weight changes are associated with alterations in lipid profile, particularly the triglyceride (TG)-to-high-density lipoprotein cholesterol (HDL-C) ratio (TG/HDL-C). Methods: In this retrospective analysis of subjects referred to medical screening, body mass index (BMI), low-density lipoprotein cholesterol (LDL-C), TG, and HDL-C levels were measured annually. Patients were divided according to BMI changes between visits. The primary outcomes were the changes in LDL-C, TG, HDL-C, and the TG/HDL-C ratio between visits. Results: The final analysis included 18,828 subjects. During the year of follow-up, 9.3% of the study population lost more than 5% of their weight and 9.2% gained more than 5% of their weight. The effect of weight changes on TG and on the TG/HDL-C ratio was remarkable. Patients with greater BMI increases showed greater increases in their TG/HDL-C ratio, and conversely, a decreased BMI level had lower TG/HDL-C ratios. This is true even for moderate changes of more than 2.5% in BMI. Conclusions: Non-interventional weight changes, even modest ones, are associated with significant alterations in the lipid profile. Understanding that modest, non-interventional weight changes are associated with alterations in the TG/HDL-C ratio may aid in better risk stratification and primary prevention of CV morbidity and mortality.
B Cells Dynamic in Aging and the Implications of Nutritional Regulation
Authors: Yu Yifei , Lu Chenxu , Yu Weiru , Lei Yumei , Sun Siyuan , Liu Ping , Bai Feirong , Chen Yu , Chen Juan
Published: February 2024

Aging negatively affects B cell production, resulting in a decrease in B-1 and B-2 cells and impaired antibody responses. Age-related B cell subsets contribute to inflammation. Investigating age-related alterations in the B-cell pool and developing targeted therapies are crucial for combating autoimmune diseases in the elderly. Additionally, optimal nutrition, including carbohydrates, amino acids, vitamins, and especially lipids, play a vital role in supporting immune function and mitigating the age-related decline in B cell activity. Research on the influence of lipids on B cells shows promise for improving autoimmune diseases. Understanding the aging B-cell pool and considering nutritional interventions can inform strategies for promoting healthy aging and reducing the age-related disease burden.
Formulated Palmitoylethanolamide Supplementation Improves Parameters of Cognitive Function and BDNF Levels in Young, Healthy Adults: A Randomised Cross-Over Trial
Authors: Kim Nadia , Parolin Brenda , Renshaw Derek , Deb Sanjoy K. , Zariwala Mohammed Gulrez
Published: February 2024

Background: Palmitoylethanolamide (PEA) is an endocannabinoid-like lipid mediator which is naturally produced in the body and found in certain foods. The aim of this study was to assess the effect of a bioavailable formulated form of PEA (Levagen+®) on serum BDNF levels and parameters of cognitive function in healthy adults. Methods: A randomised double-blinded placebo-controlled cross-over trial was implemented to measure the effects of a 6-week 700 mg/day course of formulated PEA supplementation versus a placebo. Participants (n = 39) completed pre- and post-assessments of a lab-based cognitive test. Serum samples were collected to measure BDNF concentrations using an immunoassay. Results: A significant increase in serum BDNF levels was found following PEA supplementation compared with the placebo (p = 0. 0057, d = 0.62). The cognition test battery demonstrated improved memory with PEA supplementation through better first success (p = 0.142, d = 0.54) and fewer errors (p = 0.0287; d = −0.47) on the Paired Associates Learning test. Conclusion: This was the first study to report a direct beneficial effect of Levagen+® PEA supplementation on memory improvement as well as corresponding increases in circulating neurotrophic marker levels. This suggests that formulated PEA holds promise as an innovative and practical intervention for cognitive health enhancement.
Metabolomic Biomarkers of Dietary Approaches to Stop Hypertension (DASH) Dietary Patterns in Pregnant Women
Authors: Chen Liwei , Dai Jin , Yu Guoqi , Pang Wei Wei , Rahman Mohammad L. , Liu Xinyue , Fiehn Oliver , Guivarch Claire , Chen Zhen , Zhang Cuilin
Published: February 2024

Objective: the aim of this study was to identify plasma metabolomic markers of Dietary Approaches to Stop Hypertension (DASH) dietary patterns in pregnant women. Methods: This study included 186 women who had both dietary intake and metabolome measured from a nested case-control study within the NICHD Fetal Growth Studies–Singletons cohort (FGS). Dietary intakes were ascertained at 8–13 gestational weeks (GW) using the Food Frequency Questionnaire (FFQ) and DASH scores were calculated based on eight food and nutrient components. Fasting plasma samples were collected at 15–26 GW and untargeted metabolomic profiling was performed. Multivariable linear regression models were used to examine the association of individual metabolites with the DASH score. Least absolute shrinkage and selection operator (LASSO) regression was used to select a panel of metabolites jointly associated with the DASH score. Results: Of the total 460 known metabolites, 92 were individually associated with DASH score in linear regressions, 25 were selected as a panel by LASSO regressions, and 18 were identified by both methods. Among the top 18 metabolites, there were 11 lipids and lipid-like molecules (i.e., TG (49:1), TG (52:2), PC (31:0), PC (35:3), PC (36:4) C, PC (36:5) B, PC (38:4) B, PC (42:6), SM (d32:0), gamma-tocopherol, and dodecanoic acid), 5 organic acids and derivatives (i.e., asparagine, beta-alanine, glycine, taurine, and hydroxycarbamate), 1 organic oxygen compound (i.e., xylitol), and 1 organoheterocyclic compound (i.e., maleimide). Conclusions: our study identified plasma metabolomic markers for DASH dietary patterns in pregnant women, with most of being lipids and lipid-like molecules.
Effects of Clostridium tyrobutyricum on Lipid Metabolism, Intestinal Barrier Function, and Gut Microbiota in Obese Mice Induced by High-Fat Diet
Authors: Luo Yanqiu , Jin Yuyue , Wang Haidong , Wang Geng , Lin Yueying , Chen Haohan , Li Xinyu , Wang Minqi
Published: February 2024

Obesity and its complications constitute a main threat to global human health. The purpose of this investigation was to explore the influences of Clostridium tyrobutyricum (Ct) on lipid metabolism, intestinal barrier function, and intestinal microbiome in obese mice induced by a high-fat diet (HFD). After establishing the obesity model, 107 CFU/mL and 108 CFU/mL C. tyrobutyricum were used to intervene in HFD-fed mice by gavage for six weeks, and indexes related to obesity were measured. In the liver of HFD-fed mice, the results revealed that C. tyrobutyricum reduced liver weight and the levels of triglyceride (TG), total cholesterol (TC), and nonesterified fatty acid (NEFA), along with decreasing red lipid droplets and fat vacuoles. After C. tyrobutyricum intervention, the mRNA expression of peroxisome proliferator-activated receptor-γ (PPARγ) was downregulated, and AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptor-α (PPARα), adipose triglyceride lipase (ATGL), and hormone-sensitive lipase (HSL) were upregulated in the liver. Additionally, C. tyrobutyricum alleviated intestinal morphology injury caused by HFD, decreased the expression of tumor necrosis factor-α (TNF-α), interleukin 6 (IL-6), and IL-1β in the colon, and upregulated tight junction protein expression. In addition, 16S rRNA sequencing revealed that C. tyrobutyricum increases the diversity of intestinal microbiota. Overall, C. tyrobutyricum improved HFD-induced lipid metabolism disorders, preserved the intestinal barrier’s integrity, and modulated the structure of the intestinal microbiome. These findings provide a novel insight into the role of C. tyrobutyricum as a probiotic in regulating lipid metabolism.
Development of a Versatile Lipid Core for Nanostructured Lipid Carriers (NLCs) Using Design of Experiments (DoE) and Raman Mapping
Authors: Rios Carlos Alberto , Ondei Roberta , Breitkreitz Márcia Cristina
Published: February 2024

The objective of this study was to develop a versatile lipid core for the ‘brick-dust type of drugs’ (poorly water-soluble and poorly lipid-soluble drugs). In the first step, excipients of different polarities were classified according to their behavior in aqueous solutions. Subsequently, binary mixtures were prepared with cetyl palmitate (Crodamol™ CP pharma, Campinas, São Paulo, Brazil) as the solid lipid, and its miscibility with other excipients was evaluated using Raman mapping and classical least squares (CLS). Based on the results, the excipients Crodamol™ CP pharma (hydrophobic), Super Refined™ DMI (dimethyl isosorbide; hydrophilic, Mill Hall, PA, USA), and Super Refined™ Lauryl Lactate (lauryl lactate, medium polarity, Mill Hall, PA, USA) were chosen to compose the lipid core. The ideal proportion of these excipients was determined using a mixture design and the standard deviation (STD) of image histograms as the response variables. After statistical evaluation of the DoE results, the final composition was determined, and drugs with different logP (0 to 10) and physicochemical characteristics were evaluated in the optimized mixture. The drugs butamben (Sigma-Aldrich Co., Spruce Street, St. Louis, MO, USA), tacrolimus (NutriFarm, São Paulo, Brazil), atorvastatin calcium, and resveratrol (Botica da Terra, Campinas, Brazil) presented a homogeneous distribution in the optimized lipid core, indicating that this is a promising system to be used in nanostructured lipid carrier (NLC) formulations of such types of drugs.
Associations between Ocular Biometry, Refractive Error, and Body Characteristics
Authors: Noya-Padin Veronica , Nores-Palmas Noelia , Garcia-Queiruga Jacobo , Giraldez Maria J. , Pena-Verdeal Hugo , Yebra-Pimentel Eva
Published: February 2024

Myopia is a refractive error widely spread throughout the world, usually related to excessive axial length (AL) of the eye. This elongation could have severe consequences, even leading to blindness. However, AL varies among subjects, and it may be correlated with other anthropometric parameters. The aim of this study was to evaluate the relationships between AL, body height, refractive error, and sex. A total of 72 eyes of 36 myopic participants with a mean age of 11.1 ± 1.42 years (ranging from 8 to 14 years) were included in the study. Participants underwent objective refraction by NVision-K5001, AL measurement by Topcon MYAH biometer, and body height measurement. Significant correlations were observed between AL, body height, and spherical equivalent (SE) (Spearman’s correlation, all p ≤ 0.016). When participants were grouped by AL, significant differences were observed for body height and SE, and when grouped by height percentile, significant differences were observed for AL and SE (Kruskal–Wallis test, all p ≤ 0.006). There was a significant difference in SE, AL, and body height between genders (Mann–Whitney U test, all p ≤ 0.038). AL relates to the refractive state of the eye and is also influenced by individual anatomical characteristics.
Belowground Response of a Bahiagrass Pasture to Long-Term Elevated [CO2] and Soil Fertility Management
Authors: Runion G. Brett , Prior Stephen A. , Torbert H. Allen
Published: February 2024

Effects of rising atmospheric CO2 concentration [CO2] on pastures and grazing lands are beginning to be researched, but these important systems remain understudied compared to other agronomic and forest ecosystems. Therefore, we conducted a long-term (2005–2015) study of bahiagrass (Paspalum notatum Flüggé) response to elevated [CO2] and fertility management. The study was conducted at the USDA-ARS, National Soil Dynamics Laboratory open-top field chamber facility, Auburn, AL. A newly established bahiagrass pasture was exposed to either ambient or elevated (ambient + 200 µmol mol−1) [CO2]. Following one year of pasture establishment, half the plots received a fertilizer treatment [N at 90 kg ha−1 three times yearly plus P, K, and lime as recommended by soil testing]; the remaining plots received no fertilization. These treatments were implemented to represent managed (M) and unmanaged (U) pastures; both are common in the southeastern US. Root cores (0–60 cm depth) were collected annually in October and processed using standard procedures. Fertility additions consistently increased both root length density (53.8%) and root dry weight density (68.2%) compared to unmanaged plots, but these root variables were generally unaffected by either [CO2] or its interaction with management. The results suggest that southern bahiagrass pastures could benefit greatly from fertilizer additions. However, bahiagrass pasture root growth is unlikely to be greatly affected by rising atmospheric [CO2], at least by those levels expected during this century.
Development of Biocompatible Digital Light Processing Resins for Additive Manufacturing Using Visible Light-Induced RAFT Polymerization
Authors: Sarabia-Vallejos Mauricio A. , De la Fuente Scarleth Romero , Tapia Pamela , Cohn-Inostroza Nicolás A. , Estrada Manuel , Ortiz-Puerta David , Rodríguez-Hernández Juan , González-Henríquez Carmen M.
Published: February 2024

Patients with bone diseases often experience increased bone fragility. When bone injuries exceed the body’s natural healing capacity, they become significant obstacles. The global rise in the aging population and the escalating obesity pandemic are anticipated to lead to a notable increase in acute bone injuries in the coming years. Our research developed a novel DLP resin for 3D printing, utilizing poly(ethylene glycol diacrylate) (PEGDA) and various monomers through the PET-RAFT polymerization method. To enhance the performance of bone scaffolds, triply periodic minimal surfaces (TPMS) were incorporated into the printed structure, promoting porosity and pore interconnectivity without reducing the mechanical resistance of the printed piece. The gyroid TPMS structure was the one that showed the highest mechanical resistance (0.94 ± 0.117 and 1.66 ± 0.240 MPa) for both variants of resin composition. Additionally, bioactive particles were introduced to enhance the material’s biocompatibility, showcasing the potential for incorporating active compounds for specific applications. The inclusion of bioceramic particles produces an increase of 13% in bioactivity signal for osteogenic differentiation (alkaline phosphatase essay) compared to that of control resins. Our findings highlight the substantial improvement in printing precision and resolution achieved by including the photoabsorber, Rose Bengal, in the synthesized resin. This enhancement allows for creating intricately detailed and accurately defined 3D-printed parts. Furthermore, the TPMS gyroid structure significantly enhances the material’s mechanical resistance, while including bioactive compounds significantly boosts the polymeric resin’s biocompatibility and bioactivity (osteogenic differentiation).
Long-Chain Bio-Based Nylon 514 Salt: Crystal Structure, Phase Transformation, and Polymerization
Authors: Li Zihan , Zhang Lei , Zhang Xiaohan , Chen Tianpeng , Yang Pengpeng , Chen Yong , Lin Huajie , Zhuang Wei , Wu Jinglan , Ying Hanjie
Published: February 2024

Nylon 514 is one of the new long-chain bio-based nylon materials; its raw material, 1,5-pentanediamine (PDA), is prepared by biological techniques, using biomass as the raw material. The high-performance monomer of nylon 514, 1,5-pentanediamine-tetradecanedioate (PDA-TDA) salt, was obtained through efficient crystallization methods. Here, two crystal forms of PDA-TDA, anhydrous and dihydrate, were identified and studied in this paper. From the characterization data, their crystal structures and thermal behaviors were investigated. Lattice energy was calculated to gain further insight into the relationship between thermal stability and crystal structures. The contribution of hydrogen bonds and other intermolecular interactions to the crystal structure stability have been quantified according to detailed Hirshfeld and IRI analyses. Additionally, the transformation mechanism of the anhydrate and dihydrate was established through a series of well-designed stability experiments, in which the temperature and water activity play a significant role in the structural stability of crystalline forms. Eventually, we obtained nylon 514 products with good thermal stability and low absorption using stable dihydrate powders as monomers. The properties of nylon 514 products prepared by different polymerization methods were also compared.
Hydrocarbon Source Rock Evaluation of the Lucaogou Shale in the Periphery of Bogeda Mountain (SE Junggar Basin, China) and Its Implications for Shale Oil Exploration: Insights from Organic Geochemistry, Petrology, and Kinetics Pyrolysis
Authors: Zhang Guanlong , Yang Yuqiang , Liu Tianjiao , Xu Youde , Chang Xiangchun , Qu Yansheng , Shi Bingbing , Yang Bo , Song Tao
Published: February 2024

Since the discovery of the vast Jimusaer shale oilfield in the southeastern Junggar Basin in 2012, there has been considerable interest in neighboring areas around Bogeda Mountain that have shale oil potential. The primary productive interval in the basin, the Middle Permian Lucaogou Formation (P2l), is well-developed in the areas of Qitai, Mulei, Shiqiantan, Chaiwopu, and Miquan. In this study, we conducted an assessment of the hydrocarbon generation potential of the P2l in these five areas and compared it with that of the P2l in the Jimusaer oilfield, which were determined by GC-MS, total organic carbon (TOC) and vitrinite reflectance (Ro) measurements, Rock-Eval pyrolysis, and organic petrology to investigate the type, origin, thermal maturity, hydrocarbon potential, and oil/gas proneness of organic matter in the P2l. Additionally, we applied open-system pyrolysis of hydrocarbon generation kinetics to explore differences in hydrocarbon generation and expulsion across various P2l mudstone/shale in the southeastern Junggar Basin. The findings of this study revealed that the P2l shale in Qitai and Miquan areas contains more abundant and lower thermally mature organic matter (early mature–mature stage), characterized by primarily Type II1–I kerogen, similar to that found in the P2l shale of the Jimusaer oilfield. Conversely, the P2l shale in Mulei, Shiqiantan, and Chaiwopu contains less abundant and more thermally mature organic matter (mainly mature–highly mature stage), dominated by Type II2–III kerogen. Consequently, shale in these areas is considerably less desirable for oil exploration compared to the Jimusaer shale. The semi-deep to deep lake facies in Miquan and Qitai exhibit the most promising exploration potential. This study can serve as a guide for shale oil exploration in the southeastern Junggar Basin.
Performance of the Food Waste Recycling Law in Japan with Reference to SDG 12.3
Authors: Okayama Tomoko , Watanabe Kohei
Published: February 2024

SDG target 12.3 calls for halving food waste in retail, food service, and households by 2030. The food waste index developed for this purpose includes parts attached to food that are usually removed intentionally (“unavoidable food waste”) and counts conversion into animal feed and utilisation as biomaterial as a means of reduction. In Japan, the “Food Waste Recycling Law”, which has been in effect since 2001, promotes the recycling of food waste generated from businesses, designating feed conversion as a top priority. On the other hand, based on the more recent “Food Loss Reduction Promotion Act” of 2019, the government is currently promoting reduction in avoidable food waste to meet the SDG target. Based on statistical sources and interviews with ministry officers, this paper explains the history and achievements of Japan’s 23-year policy based on the Food Recycling Law, as well as the tension between the two legislations.
Afanas’ev’s Poetic Views of the Slavs’ on Nature and Its Role in Understanding Paganism and Mythology
Authors: Toporkov Andrei
Published: February 2024

The article analyzes the mythological concept of Slavic paganism developed by Alexander Afanas’ev in his three-volume study Poetic Views of the Slavs on Nature: An Attempt at a Comparative Study of Slavic Traditions and Beliefs in Connection with the Mythical Tales of Other Related Peoples (1865–1869). In this book, Afanas’ev established numerous parallels between the pagan myths of the Slavs and other Indo-European peoples and reconstructed mythological images of the world tree, the tree of life, and the world egg. He also reconstructed myths about the sacred marriage between heaven and earth; the creation of the world from the body of the first man and the creation of man from the natural elements; the dying and resurrected god of vegetation and fertility; and the duel between the god of thunderstorms and his earthly adversary; as well as dualistic myths about the struggle between the forces of light and the forces of darkness and about the creation of the earth. Afanas’ev also explored enduring metaphorical pairs such as death–dream, battle–wedding feast, thunderstorm–battle, and so on. Depending on the readers’ points of view, they can appreciate the book as a grandiose compendium of folklore and historical-ethnographic materials; as a scholarly work devoted to Slavic mythology; as a symbolarium of folk culture; and as a beautiful fairy tale about the pagan past. Although Afanas’ev’s book has all the attributes of a scholarly publication, it can also be read as a work of fiction in which the author does not so much analyze mythology as he tries to present the point of view of a primitive poet–artist.
Review of Satellite Remote Sensing and Unoccupied Aircraft Systems for Counting Wildlife on Land
Authors: Attard Marie R. G. , Phillips Richard A. , Bowler Ellen , Clarke Penny J. , Cubaynes Hannah , Johnston David W. , Fretwell Peter T.
Published: February 2024

Although many medium-to-large terrestrial vertebrates are still counted by ground or aerial surveys, remote-sensing technologies and image analysis have developed rapidly in recent decades, offering improved accuracy and repeatability, lower costs, speed, expanded spatial coverage and increased potential for public involvement. This review provides an introduction for wildlife biologists and managers relatively new to the field on how to implement remote-sensing techniques (satellite and unoccupied aircraft systems) for counting large vertebrates on land, including marine predators that return to land to breed, haul out or roost, to encourage wider application of these technological solutions. We outline the entire process, including the selection of the most appropriate technology, indicative costs, procedures for image acquisition and processing, observer training and annotation, automation, and citizen science campaigns. The review considers both the potential and the challenges associated with different approaches to remote surveys of vertebrates and outlines promising avenues for future research and method development.
The Impact of Diurnal Variability of Sea Surface Temperature on Air–Sea Heat Flux Estimation over the Northwest Pacific Ocean
Authors: Tu Qianguang , Hao Zengzhou , Liu Dong , Tao Bangyi , Shi Liangliang , Yan Yunwei
Published: February 2024

Accurate and consistent observations of diurnal variability of sea surface temperature (SST DV) and its impact on air–sea heat fluxes over large areas for extended periods are challenging due to their short time scale and wide coverage. The hourly gap-free SSTs generated from Japan Aerospace Exploration Agency-Japan Agency for Marine–Earth Science and Technology (JAXA-JAMSTEC) are input to the COARE3.5 bulk flux algorithm to investigate the impact of SST DV on air–sea heat fluxes over the Northwest Pacific Ocean (NWPO). The main results are as follows. (1) The JAXA-JAMSTEC SSTs were found to be in good agreement with the buoy observations on SST DV with a very slight negative bias of −0.007 °C and a root mean square error of 0.018 °C. (2) The case study conducted on 26 June 2020 showed that the fluxes’ diurnal amplitudes were about 30–50 W m−2, and evolution was in agreement with SST DV. (3) The average impact of SST DV on heat fluxes was 2.93 W m−2 over the subtropical NWPO, decreasing from southeast to northwest and from low to high latitudes, and showing a clear seasonal cycle during 2019–2022. This research highlights the need to consider SST DV for accurate estimation of heat fluxes, which is crucial for climate and atmospheric studies.
Inversion of Sub-Bottom Profile Based on the Sediment Acoustic Empirical Relationship in the Northern South China Sea
Authors: Zhou Qingjie , Li Xianfeng , Zheng Jianglong , Li Xishuang , Kan Guangming , Liu Baohua
Published: February 2024

This study focuses on the inversion of sub-bottom profile (SBP) data in the northern South China Sea using an empirical relationship derived from sediment acoustic data. The sub-bottom profile is primarily utilized for various marine applications, such as geological mapping and resource exploration. In this research, we present a study conducted in the northern slope canyon of the South China Sea. Firstly, we obtained the seabed reflection coefficient from sub-bottom profiles obtained by the autonomous underwater vehicle (AUV) detection system. Secondly, we utilized the acoustic empirical relationship in the northern South China Sea to establish relationship equations between the seabed reflection coefficient and the porosity, density, and average particle size of the sediment at a main frequency of 4 kHz (the AUV shallow profile main frequency). Then, using these equations, we were able to invert the physical parameters such as porosity, density, and average particle size of the seabed surface sediments. Finally, the inverted results are compared and analyzed by using the sediment samples test data. The overall deviation rate of the inverted physical parameters is within the range of ±10% when compared. The inverted results closely match the measured values, accurately reflecting the dynamic changes in the physical properties of seabed surface sediments. Notably, the average grain size is a direct indicator of the sediment particles size with smaller particles found in deeper water. The variation characteristics of sediment physical parameters align well with the variation of sediment types in the canyon, which is consistent with changes in the water depth, topography, and hydrodynamic conditions of the area. This further demonstrates the reliability of the inversion results.
Vulnerable Road User Skeletal Pose Estimation Using mmWave Radars
Authors: Zeng Zhiyuan , Liang Xingdong , Li Yanlei , Dang Xiangwei
Published: February 2024

A skeletal pose estimation method, named RVRU-Pose, is proposed to estimate the skeletal pose of vulnerable road users based on distributed non-coherent mmWave radar. In view of the limitation that existing methods for skeletal pose estimation are only applicable to small scenes, this paper proposes a strategy that combines radar intensity heatmaps and coordinate heatmaps as input to a deep learning network. In addition, we design a multi-resolution data augmentation and training method suitable for radar to achieve target pose estimation for remote and multi-target application scenarios. Experimental results show that RVRU-Pose can achieve better than 2 cm average localization accuracy for different subjects in different scenarios, which is superior in terms of accuracy and time compared to existing state-of-the-art methods for human skeletal pose estimation with radar. As an essential performance parameter of radar, the impact of angular resolution on the estimation accuracy of a skeletal pose is quantitatively analyzed and evaluated in this paper. Finally, RVRU-Pose has also been extended to the task of estimating the skeletal pose of a cyclist, reflecting the strong scalability of the proposed method.