bluuebunny/crossref_metadata_2025 huggingface dataset:
Photonic hyperinterfaces for light manipulations
Authors: Zhang Shibin , Xu Yadong , Chen Huanyang , Cao Yanyan , Gao Lei , Huang Hao , Zhou Hongyan , Ou Xin
Published: May 2020

Optical metamaterials are building blocks for the control of light
behaviors and designs of photonic devices, where the inner interfaces
in deep-subwavelength features are expected to have little impact on
light transport, based on the concept of homogenization. Here we
theoretically and experimentally study a new type of photonic
interface (namely a hyperinterface) inside an optical metamaterial
made of a zigzag alternating multilayer structure [namely structured
metamaterials (SMMs)] in the deep-subwavelength regime. It is found
that the subwavelength hyperinterfaces play a great role in the
optical properties of such SMMs, and the electromagnetic properties of
the hyperinterfaces can be effectively manipulated in a feasible way.
In particular, the absorption of the SMMs strongly depends not only on
the intrinsic absorption of the SMMs’ unit cells, but also on the
structural absorption that is induced by the hyperinterfaces inside
the SMMs and their period

p

, even for the long wavelength
limitation. These outcomes are attributed to the dispersion relations
of the hyperinterfaces, that is, the interplay of the angle formed by
the asymptotes of the iso-frequency contour (hyperbola) of the SMMs’
unit cells and the geometric rotating angle of zigzag structures. Such
interplay leads to an effect of clipping and the recombination of
energy flow distributions at the hyperinterfaces. Our findings may
pave the way to the manipulation of a light field to enhance the
conversion efficiency of optoelectronic devices, e.g., solar cells and
photodetectors.
High efficiency cascaded third-harmonic generation in a quasi-periodically poled KTiOPO4 crystal
Authors: Vernay Augustin , Bonnet-Gamard Lucas , Boutou Véronique , Trajtenberg-Mills Sivan , Arie Ady , Boulanger Benoît
Published: May 2020

We performed and studied cascaded third-harmonic generation (THG) in a quasi-periodically poled KTP (QPPKTP) crystal allowing simultaneous phase-matching of the two cascading steps ω + ω → 2ω and 2ω + ω → 3ω. The phase-matching was achieved at the fundamental wavelength λω = 1587 nm when the QPPKTP crystal was heated to 95°C. The energy conversion efficiency reached 40% in the picosecond regime for a fundamental energy of 20 µJ that corresponds to an intensity of 1.5 GW/cm2. It is the highest value of THG efficiency ever reported to the best of our knowledge. The modeling in the case of the depleted pump regime accurately described the experiments.
Treatment Response Monitoring with Diffuse Optical Tomography-Based Multimodal Breast Imaging
Authors: Deng Bin , Kabeer Aiza , Cormier Jayne , Saksena Mansi , Carp Stefan A.
Published: May 2020

We discuss various quantitative functional imaging markers derived from diffuse optical tomography, used either as a standalone system or in combination with other clinical breast imaging modalities, for treatment response monitoring in breast cancer patients.
Pretreatment Prediction of Neoadjuvant Chemotherapy Response in HER-2 Positive Breast Cancer Patients Using Diffuse Optical Tomography Imaging
Authors: Altoe Mirella L. , Marone Alessandro , Kim Hyun K. , Tejada Mariella , Hibshoosh Hanina , Guo Hua , Crew Katherine D. , Accordino Melissa K. , Trivedi Meghna , Kalinsky Kevin , Hershman Dawn L. , Hielscher Andreas H.
Published: May 2020

Normalized ctTHb levels measured prior to neoadjuvant chemotherapy can predict breast cancer response to NAC and potentially be used to improve personalized therapeutic strategies for HER-2 positive tumors.
Real-time single fiber based multispectral monitoring of cardiac ablation therapy
Authors: Park Soo-Young , Singh-Moon Rajinder P. , Hendon Christine
Published: May 2020

A combined multispectral single fiber-radiofrequency ablation (RFA) catheter is developed to assess irrigated endocardial lesion formation. Validation is performed ex vivo on swine experimental models.
A Machine Learning Approach to Determining Sub-Diffuse Optical Properties
Authors: Stier Andrew C. , Goth Will , Zhang Yao , Fox Matthew C. , Reichenberg Jason S. , Lopes Fabiana C.P.S. , Sebastian Katherine R. , Markey Mia K. , Tunnell James W.
Published: May 2020

We demonstrate a machine learning approach that renders real-time subdiffuse optical property (γ) maps from spatial frequency domain images, laying the foundation for use in surgical guidance.
AdaBoost-based multi-wavelength spatial frequency domain imaging for human colorectal tissue assessment
Authors: Li Shuying , Zeng Yifeng , Chapman William C. , Erfanzadeh Mohsen , Alipour Zahra , Abdelal Heba , Mutch Matthew , Zhu Quing
Published: May 2020

A multi-wavelength spatial frequency domain imaging (SFDI) system combined with AdaBoost classifier was used to automatically classify ex vivo human colorectal tissues. A sensitivity of 89.7% and a specificity of 91.8% were achieved.
Measurement of Circulating Tumor Cell Dynamics in Mice with Diffuse in Vivo Flow Cytometry
Authors: Williams Amber L. , Fitzgerald Jessica , Niedre Mark
Published: May 2020

We developed a diffuse light technique for fluorescence detection of circulating tumor cells directly in circulation in vivo. Here, we show that CTC numbers change rapidly over short timescales, which is undetectable with blood draws.
Time-domain Near Infrared Optical Tomography Guided Fluorescence Molecular Tomography
Authors: Ren Wuwei , Jiang Jingjing , Di Costanzo Aldo M. , Kalyanov Alexander , Wolf Martin
Published: May 2020

We propose a multimodal imaging method by combining continuous-wave fluorescence molecular tomography (FMT) with time-domain near infrared optical tomography (NIROT). Phantom experiments have demonstrated that using the NIROT-derived optical properties improves the FMT reconstruction significantly.
High Signal-to-Noise Ratio and Depth Penetration in Time-Domain Functional Near-Infrared Spectroscopy Combining Large Area Detector and High Throughput Electronics
Authors: Mora Alberto Dalla , Di Sieno Laura , Behera Anurag , Rohilla Sumeet , Ferocino Edoardo , Contini Davide , Krämer Benedikt , Koberling Felix , Torricelli Alessandro , Pifferi Antonio
Published: May 2020

A time-domain functional near-infrared spectroscopy system with probe-hosted large-area detector capable of a throughput of 30 million of counts per second is presented and validated on phantoms and in vivo.
High-speed Frequency Domain Diffuse Optical Spectroscopy for Quantitative Pulse Oximetry
Authors: Applegate Matthew B. , Istfan Raeef , Pande Ashvin , Roblyer Darren
Published: May 2020

Following cardiac surgery, patients are monitored with a catheter inserted into the heart. High-speed frequency domain diffuse optical spectroscopy can noninvasively measure many of the same parameters as the invasive catheter without risk of complications.
A Cost Effective and Low Footprint Hyperspectral Bioluminescent Tomography System Based on Compressive Sensing
Authors: Bentley Alexander , Rowe Jonathan E. , Dehghani Hamid
Published: May 2020

A low cost bioluminescent tomography system is developed, utilizing compressive sensing to collect hyperspectral data of biologically informative light at the surface of an animal. This method is shown to improve data collection time and source localization.
Determination of Particle Size from Reconstructed Angular Backscattering Through a Single Multimode Fiber
Authors: Zhang Haoran , Steelman Zachary A. , Wax Adam
Published: May 2020

We demonstrate the use of a transmission matrix approach to reconstruct angular backscattering profiles through a single multimode fiber, with an accurate determination of the scatterer’s size based on Mie theory.
Quantitative Phase-Based Angular Scattering Measurements of Organelle Size Distributions in Single Cells
Authors: Berger Andrew J. , Draham Robert L. , Dunn Kaitlin J.
Published: May 2020

Angular scattering from wavelength-scale objects can be obtained from quantitative phase images. Using Fourier phase microscopy, excellent fits with Mie theory are obtained for single micron-scale beads, and size distribution estimates are performed for the first time on various single cells.
Wearable High-Density Diffuse Optical Tomography (HD-DOT) for Unrestricted 3D Functional Neuroimaging
Authors: Vidal-Rosas Ernesto E. , Hill Reuben , Smith Greg , Dunne Luke , Zhao Hubin , Powell Samuel , Everdell Nick L. , Cooper Robert J
Published: May 2020

We introduce a new wearable HD-DOT system that allows neuroimaging in naturalistic environments. Test results with visual paradigms show comparable performance to larger fiber-based systems, while extra-laboratory recordings demonstrate the feasibility of unrestricted brain imaging.
A Wearable Diffuse Optical Tomography Patch for Investigating Pressure Injuries
Authors: Day Bradford , Pollonini Luca
Published: May 2020

Pressure injuries are wounds to skin and underlying tissues potentially originating from reduced tissue oxygenation. To elucidate pressure injuries’ initiation mechanisms, we developed a body-conforming diffuse optical imaging patch to measure tissue hemodynamics in real time.
Comparison of Dynamic and Static Assessment of Cerebral Autoregulation in Non-Human Primates
Authors: Ruesch Alexander , Yang Jason , Acharya Deepshikha , Schmitt Samantha , Smith Matthew A. , Kainerstorfer Jana M.
Published: May 2020

Measurements of static and dynamic cerebral autoregulation were performed in nonhuman primates. Comparison of changes in intracranial and arterial blood pressure are discussed for their influence on autoregulatory responses measured non-invasively with diffuse optical instruments.
Multi-Distance Frequency-Domain Optical Measurements of Cerebral Blood Flow During Hypercapnia
Authors: Pham Thao , Blaney Giles , Sassaroli Angelo , Fernandez Cristianne , Balberg Michal , Fantini Sergio
Published: May 2020

We report non-invasive dynamic measurements of cerebral blood flow in three healthy human subjects during hypercapnia. Frequency-domain measurements using single-distance phase are more sensitive to deeper brain tissue than using single-distance intensity.
Ultrasonically-assisted in-situ Micro-endoscopic Optical Imaging
Authors: Scopelliti Matteo Giuseppe , Karimi Yasin , Chamanzar Maysamreza
Published: May 2020

A novel technique is presented for micro-endoscopy in which ultrasonic waves will alter the optical properties of tissue for sculpting virtual optical waveguides with graded refractive index profiles to guide and focus photons through the medium. Using this technique, images of target objects can be relayed through a turbid medium without implanting a physical endoscope. We demonstrate imaging of fluorescent objects with feature sizes as small as 22 µm through a scattering tissue phantom. The presented method can also enable in situ volumetric scanning of the medium by changing the pattern and intensity of ultrasonic waves. We demonstrate that arbitrary patterns of light can be sculpted in the target medium in the form of dipole, quadrupole and higher-order beam patterns using a multi-segment cylindrical ultrasonic array.
All-optical Reflection-mode Microscopic Histology of Unstained Human Tissues
Authors: Abbasi Saad , Le Martin , Ecclestone Benjamin , Abu-Sardanah Serene , Bell Kevan , Dinakaran Deepak , Bigras Gilbert , Mackey John R. , Reza Parsin Haji
Published: May 2020

Current methods to visualize cancer margins can be time consuming or unreliable. Employing PARS microscopy, the first non-contact reflection-mode label-free histology-like images of cellular morphology in unstained thin and thick human tissue samples are presented.
In Vivo Raster-Scan Optoacoustic Angiography of Superficial Tissues
Authors: Orlova Anna , Sirotkina Marina , Turchin Ilya , Subochev Pavel
Published: May 2020

The possibilities of optoacoustic microscopy to study vascular network of healthy animal tissues and growing experimental tumor as well as to study the dynamics of blood content of human skin during occlusive test were demonstrated.
A low frame rate camera based Diffuse Correlation Spectroscopy (DCS) system to measure blood flow in human adult brain
Authors: K Murali , Varma Hari M
Published: May 2020

We present a low frame rate camera based diffuse correlation spectroscopy (DCS) system to compute field auto-correlation function for measuring in-vivo blood flow in healthy human adult brain.
Spatial Frequency Domain Imaging for Bone Graft Healing in a Mouse Femoral Model
Authors: Ren Jingxuan , Ramirez Gabriel A. , Proctor Ashley R. , Choe Regine
Published: May 2020

A spatial frequency domain imaging (SFDI) technique was applied for monitoring the healing process of mouse femoral grafts. Preliminary results show different total hemoglobin concentration in two types of bone grafts.
Noncontact Multiscale Speckle Contrast Diffuse Correlation Tomography (scDCT) of Deep Tissue Hemodynamics
Authors: Yu Guoqiang , Huang Chong , Zhao Mingjun , Mazdeyasna Siavash
Published: May 2020

This paper summarizes our recent progresses in developing and applying an innovative noncontact, multiscale, speckle contrast diffuse correlation tomography (scDCT) for rapid and high-density 3D imaging of tissue blood flow distributions in animals and humans.
Clinical Applications of TD-NIRS: a Widespread Scenario
Authors: Re R. , Spinelli L. , Contini D. , Pirovano I. , Zanoletti M. , Cubeddu R. , Torricelli A.
Published: May 2020

TD-NIRS allows the monitoring of tissue hemodynamics enhancing the contribution from the late (deeper) photons. After a brief review of its peculiarities, examples of its employment in clinics, on brain and muscles, will be presented
Compressive Sensing Based Spatial Frequency Domain Imaging Reconstruction
Authors: Mellors Ben O. L. , Howle Christopher R. , Spear Abigail M. , Dehghani Hamid
Published: May 2020

Compressive sensing methods demonstrate the ability to collect large data sets using a reduced number of observations. Here we present advantages of compressive sensing applied to Spatial Frequency Domain Imaging.
Shaping-up sensitivity profiles of diffuse reflectance measurements
Authors: Sawosz Piotr , Liebert Adam
Published: May 2020

We propose method to improve depth-selective assessment of absorption changes in time-resolved near-infrared spectroscopy. The method is based on analysis of distributions of time of flight of photons acquired for two closely located detection and emitting spots.
Noninvasive Measurement of Placental Hemodynamics with Ultrasound-guided FD-Diffuse Optical Spectroscopy
Authors: Wang Lin , Schwartz Nadav , Cochran Jeffrey M. , Ko Tiffany , Baker Wesley , He Lian , Abramson Kenneth , Yodh Arjun
Published: May 2020

A sensitive heterodyne FD-DOS instrument was built and integrated with ultrasound for noninvasive monitoring of placental hemodynamics. Preliminary clinical results suggest a correlation between optical measurements and pregnancy outcome.
Polarization-independent highly efficient generation of Airy optical beams with dielectric metasurfaces
Authors: Yu Binbin , Wen Jing , Chen Lei , Zhang Leihong , Fan Yulong , Dai Bo , Kanwal Saima , Lei Dangyuan , Zhang Dawei
Published: May 2020

Airy optical beams have emerged to hold enormous theoretical and experimental research interest due to their outstanding characteristics. Conventional approaches suffer from bulky and costly systems, as well as poor phase discretization. The newly developed metasurface-based Airy beam generators have constraints of polarization dependence or limited generation efficiency. Here, we experimentally demonstrate a polarization-independent silicon dielectric metasurface for generation of high-efficiency Airy optical beams. In our implementation, rather than synchronous manipulation of the amplitude and phase by plasmonic or Huygens’ metasurfaces, we employ and impose a 3/2 phase-only manipulation to the dielectric metasurface, consisting of an array of silicon nanopillars with an optimized transmission efficiency as high as 97%. The resultant Airy optical beams possess extraordinarily large deflection angles and relatively narrow beam widths. Our validated scheme will open up a fascinating doorway to broaden the application scenarios of Airy optical beams on ultracompact photonic platforms.
General Depth-resolved Attenuation Estimation method in Optical Coherence Tomography
Authors: Li Kaiyan , Liang Wenxuan , Liang Yanmei , Wan Suiren
Published: May 2020

We propose a general depth-resolved attenuation calculation algorithm to rectify under- and over-estimation biases of existing algorithms. The method affords consistently improved accuracy for practical tissues over the entire effective imaging depth.
pH-Dependency of the Physical Properties of the Nitrogen-Vacancy Centers in Diamonds
Authors: Głowacki Maciej J. , Sawczak Mirosław , Wcisło Anna , Ficek Mateusz , Bogdanowicz Robert
Published: May 2020

A fluorescence intensity, a zeta potential, and a contact angle of a series of suspensions of nanodiamonds containing negative nitrogen-vacancy color centers has been thoroughly examined in the pH range of 1.00 to 13.00.
PH characterization of urease using Raman Spectroscopy
Authors: Chauhan Manish , Jha Animesh , Subramanian Venkatraman , Valdastri Pietro
Published: May 2020

Jack bean urease is a complex biochemical enzyme with the unique monomeric structure of polypeptides with an active site containing 2 nickel ions. Its pH-based characterization is spectroscopically investigated in an acidic (Hydrochloric acid) environment for understanding its limit of detection.
Parallel Fast 3D Reconstruction for Tumor Microvascular Network in Mesoscopic Fluorescent Molecular Tomography
Authors: Chen Yang , Faulkner Denzel , Yang Fugang
Published: May 2020

To image the tumor microvascular network via mesoscopic fluorescent molecular tomography, a fast-parallel 3D reconstruction method is presented. Experiments show the Proposed algorithm suit to parallel computing and can achieve high precision and robust reconstructions.
Accelerated Image Reconstruction in Mesoscopic Fluorescence Molecular Tomography via Deep Convolutional Symmetric Network
Authors: Gong Xue , Faulkner Denzel , Yang Fugang
Published: May 2020

To perform real-time analysis and targeted therapy for metastatic tumors, we propose a method based on deep convolutional symmetric network to accelerate mesoscopic fluorescence molecular tomography. Experiments show reconstruction accuracy and speed are highly improved.
Implicit mesh-based Monte Carlo algorithm for light transport in highly-complex tissues
Authors: Yuan Yaoshen , Yan Shijie , Fang Qianqian
Published: May 2020

We propose an implicit mesh-based Monte Carlo algorithm utilizing the edges, nodes and faces in a tetrahedral mesh to facilitate light-simulations in highly-sophisticated tissues, showing hundreds-fold reduction in memory usage.
Co-registration of dual-channel fluorescence microscopy and high-resolution optical coherence tomography
Authors: Tankam Reddikumar Maddipatla Patrice
Published: May 2020

A multi-modal system with dual-channel fluorescence microscopy and high-resolution optical coherence tomography was developed to enable the co-registration of structural and functional information. The system’s performance was demonstrated with microscopic beads sandwiched between multi-layer tapes.
Maximum Information Gain Measurements for Single Molecule Discrimination.
Authors: Goun Alexei
Published: May 2020

The Kullback-Leible (KL) divergence measure between apriori and expected posteriori probability distribution was utilized in single molecule discrimination simulation to find optimal excitation wavelength. Significant improvement in discrimination efficiency is demonstrated.
Fluorescence Anisotropy in Autofluorescence Imaging and Metabolic Interpretations
Authors: Chacko Jenu V. , Eliceiri Kevin W.
Published: May 2020

Multiphoton microscopy of reduced Nicotinamide Adenine Dinucleotide(phosphate) (NAD(P)H) is an excellent tool for exploring metabolism at the single-cell level. We present the application of fluorescence anisotropy in multiphoton autofluorescence imaging. We explore time-resolved methods that can be used for metabolic interpretations: 1) the time-resolved anisotropy, 2) time-gated anisotropy and 3) steady-state anisotropy methods. These imaging schemes are achieved using a time-correlated single-photon counting microscope, allowing simultaneous pixel-wise registration of fluorescence intensity, lifetime, and anisotropy. This tool is well-suited to identify the enzyme binding states and offer new biophysical definitions for NAD(P)H imaging. We demonstrate this hyperdimensional imaging modality under an open-sourced imaging platform.
Locally Adaptive Optical Protection Filtering for Human Eyes
Authors: Ezhov Vasily A. , Vasilieva Natalia V. , Ivashkin Peter I. , Galstian Alexander M.
Published: May 2020

Dynamic range of human eyes (DEYE) is much less in compare with the dynamic range of the light brightness distribution (DLBD) on the objects of the real world scenes in the presence of direct sunlight. In this paper, the locally adaptive optical protection filtering method is suggested for smart matching the DLBD with the DEYE.
Construction of an Inexpensive, Portable Angular Scattering Microscope for use in Organelle Size Estimation
Authors: Hanna Samuel , Hoelle James , Cannaday Ashley
Published: May 2020

An angular scattering microscope with portable capabilities was constructed from inexpensive components. Here we show that the system is capable of obtaining precise and accurate size estimates of beads and single cells’ organelles.
A Molecular-MNIST Dataset for Machine Learning Study on Diffraction Imaging and Microscopy
Authors: Zhang Yan , Farrell Steve , Crowley Michael , Makowski Lee , Deslippe Jack
Published: May 2020

An image dataset of 10 different size molecules, where each molecule has 2,000 structural variants, is generated from the 2D cross-sectional projection of Molecular Dynamics trajectories. The purpose of this dataset is to provide a benchmark dataset for the increasing need of machine learning, deep learning and image processing on the study of scattering, imaging and microscopy.
Mapping Neural Correlates to Language and Biological Motion in School-Age Children with Autism Using HD-DOT
Authors: Svoboda Alexandra M. , Burns-Yocum Tracy , Sherafati Arefeh , Schroeder Mariel L. , Rafferty Sean , Culver Joseph , Eggebrecht Adam T.
Published: May 2020

This study demonstrates HD-DOT mapping of differential processing of language and biological motion between adolescents with and without autism, and that HD-DOT measured brain function correlates with social responsiveness in those with autism.
Quantifying Inter- and Intra-Observer Variability of Atlasing in Optical Intrinsic Signal Imaging
Authors: Padawer-Curry Jonah A. , Jahnavi Jharna , Licht Daniel J. , Yodh Arjun G. , Cohen Akiva S. , White Brian R.
Published: May 2020

Aligning neuroimaging datasets to an “atlas” is a key step in analysis. We quantify the variability in atlasing arising from manual landmark selection. We propose an improved method using a “scout” image and demonstrate improvements.
Refractive index mismatch monitoring of muscle tissue under pressure through micro internal reflection imaging
Authors: Ye Qing , Tian Jianguo
Published: May 2020

Micro total internal reflection imaging technique is applied to monitor the muscle tissue refractive index (RI) mismatches under pressure treatment. Increasing of pressure, the fluid RI component decreased, while the muscle fiber RI component increased.
A truncated Fourier-transform based approach for time-domain diffuse optical tomography
Authors: Mozumder Meghdoot , Tarvainen Tanja
Published: May 2020

We present a truncated Fourier series approximation for time-domain diffuse optical tomography. The approach estimated optical parameters with accuracies comparable to using the whole time-resolved data, using very low computational time and resources.
Modelling iterative optical phase conjugation through random media
Authors: Raju Michael , Jayet Baptiste , Gunther Jacqueline , Amissah Michael , Andersson-Engels Stefan
Published: May 2020

A 2D modelling study is presented on the transmission enhancement by iterative optical phase conjugation through diffusive random media. Factors affecting coherent control for enhancing the total transmission is discussed.
Wearable, low-cost device for monitoring cerebral blood flow with speckle contrast optical spectroscopy
Authors: Verma Manish , Dragojević Tanja , Ghouse Ameer , Carbonell Laura Moreno , Karadeniz Umut , Cuenca Daniel Fernandez , Vidal-Rosas Ernesto E. , Tamborini Davide , Portaluppi Davide , Buttafava Mauro , Villa Federica , Durduran Turgut
Published: May 2020

A wearable, low-cost device was developed for measuring cerebral blood flow using speckle contrast optical spectroscopy. We present its design and results from different protocols during realistic scenarios taking advantage of it being a wearable device.
Studies of free-standing boron-doped diamond sheets using optical coherence tomography
Authors: Kamińska Aleksandra M. , Ficek Mateusz , Bogdanowicz Robert , Pluciński Jerzy
Published: May 2020

The main goal of this work was to study properties of free-standing boron-doped diamond sheets using optical coherence tomography (OCT) along with signal processing of the raw data.
Texture analysis of OCT phantoms
Authors: Kulmaganbetov M. , Albon Julie , White Nick , Morgan James E
Published: May 2020

We investigated texture analysis of optical coherence tomography (OCT) phantom images. Semi-automated classifier, based on principal component analysis (PCA) and support vector machines (SVM), enables classification of phantoms with various content of medium and scatterers.
Neurovascular Coupling (NVC) in Newborns based on regional cerebral tissue oxygenation and amplitude EEG
Authors: Das Yudhajit , Liu Hanli , Tian Fenghua , Liu Yu-Lun , Kota Srinivas , Zhang Rong , Chalak Lina F
Published: May 2020

Quantitative amplitude-integrated EEG (aEEG) tracings implemented using different algorithms demonstrated heterogeneity in results, but this variability had limited impact on the determination of neurovascular coupling (NVC) in newborns with encephalopathy and showed to be insignificant.
Combining Multiphoton Spectral Imaging and Fluorescence Lifetime Imaging for In Vitro Epidermal Differentiation
Authors: Malak Monika , James Jeemol , Grantham Julie , Ericson Marica B.
Published: May 2020

Development of organs-on-a-chip calls for non-invasive methods for characterization of tissues in real-time. Multiphoton microscopy with FLIM in combination with stage-adopted cell culturing will potentially solve this problem, enabling monitoring of metabolic changes “online”.
Analysis of sialic acid based on terahertz time domain spectroscopy
Authors: Huang Zhangwei , Cao Yuqi , Chen Piaoyun , Xie Chen , Huang Pingjie , Hou Dibo
Published: May 2020

Sialic acid is a tumor marker and difficult for label-free detection. The study has revealed that it has absorption peaks in the terahertz region, which lays the foundation for the identification of serum tumor lesions.
Parametrizing confocal parameters for characterizing the optical properties of human brain tissue using high numerical aperture optical coherence tomography
Authors: Yang Jiarui , Chen Ichun Anderson , Chang Shuaibin , Tang Jianbo , Lee Blaire , Kılıç Kıvılcım , Wang Hui , Magnain Caroline , Chen Shih-chi , Fischl Bruce , Boas David A.
Published: May 2020

A systematic method was developed to parametrize confocal parameters for modeling the depth profile of optical coherence tomography images in highly scattering media. This approach enables improved quantification of optical properties of human brain tissue.
Quantifying the impact of scattering on the point spread function using a Modified Full Field Optical Coherence Tomography Setup
Authors: Zilpelwar Sharvari , Postnov Dmitry , Chen Anderson Ichun , Cheng Xiaojun , Tian Lei , Devor Anna , Boas David A.
Published: May 2020

We present the preliminary results of our depth-resolved PSF measurement in static scattering phantoms. This forms a basis for correcting the degradation of the point spread function by optical scattering.
Functional connectivity in the prefrontal cortex during a simple versus an emotional Go/No-Go task: an fNIRS study
Authors: Nguyen Thien , Condy Emma , Gandjbakhche Amir
Published: May 2020

Prefrontal connectivity was investigated during a Go/No-Go task in 42 subjects. The left-hemispheric connectivity is present in the emotional, but not the simple task. Left hemisphere has a critical role in processing emotional response inhibition.
Monte Carlo Modeling of a Photoplethysmographic (PPG) in Individuals with Obesity
Authors: Boonya-ananta Tananant , Rodriguez Andres J. , Hansen Anders K. , Hutcheson Joshua D. , Ramella-Roman Jessica C.
Published: May 2020

Continuous monitoring of Blood Pressure (BP) is desirable in the management of cardiovascular disease (CVD). Novel tools are exploring Photoplethysmography (PPG) to determine a patient BP. We utilized a Monte Carlo (MC) framework to connect the cardiovascular biomechanics and light transport associated with a PPG signal. Optical properties specific of obese and non-obese groups were used to determine their influence on the PPG waveform. Our simulation shows that the PPG signal is altered in individuals suffering from obesity, which could limit their use in BP monitoring.
Mechanical and Hemodynamic Responses of Breast Tissue During Compression
Authors: abdi Rabah Al , Deng Bin , Kabeer Aiza , Carp Stefan
Published: May 2020

Studying hemodynamic and mechanical responses of the breast during fractional mammographic compression has the potential to produce biomarkers for diagnosing breast cancer. Comparisons between measured pressure distributions and reconstructed hemodynamic images show strong correlations.
Improved Breast Cancer Diagnosis using Ultrasound guided Diffuse Optical Tomography
Authors: Uddin K M Shihab , Zhang Menghao , Brooks Frank , Anastasio Mark , Zhu Quing
Published: May 2020

Multi-step classification combining both functional and data features improve breast cancer diagnosis with sensitivity 91.1% and specificity 85.4%. Proposed method increased specificity by more than 10% compared to diagnosis with Ultrasound and functional feature only.
Skin-remitted photon path lengths: experimental study
Authors: Spigulis Janis , Lukinsone Vanesa , Rubins Uldis , Maslobojeva Anna , Kuzminskis Maris
Published: May 2020

Skin-remitted picosecond laser pulses were detected at four input-output fiber distances in the spectral range 560-800 nm. After deconvolution procedures, distributions and mean values of the remitted photon path lengths in forearm skin were analyzed.
Raman spectroscopy for adipose tissue differentiation: a pilot study
Authors: Donjuán-Loredo Guadalupe , Espinosa-Tanguma Ricardo , León-Bejarano Maritza , Salgado-Delgado Roberto , González Francisco Javier , Guevara Edgar , Ramírez-Elías Miguel
Published: May 2020

Raman spectroscopy were used to analyze adipose tissue from control, obese and diabetic in an animal model. The Raman spectra show spectral features related to each metabolic condition.
Skeletal Muscle Oxygen Consumption Measurements with Dual-Slope Frequency-Domain Near-Infrared Spectroscopy
Authors: Fernandez Cristianne , Blaney Giles , Pham Thao , Sassaroli Angelo , Fantini Sergio
Published: May 2020

We show that dual-slope phase measurements of oxygen consumption with frequency-domain spectroscopy in skeletal muscle are less sensitive to a superficial layer compared to intensity measurements at a single source-detector distance.
A solid phantom recipe and exploration for biophotonics applications: a step to produce standardized tissue phantoms
Authors: Sekar Sanathana Konugolu Venkata , Pacheco Andrea , Martella Pierluigi , Li Haiyang , Lanka Pranav , Pifferi Antonio , Andersson-Engels Stefan
Published: May 2020

A well-characterized broadband (600-1100 nm) phantom recipe was presented to manufacture tissue-mimicking optical phantoms over a wider range of optical properties (absorption 0.1-1 cm−1, reduced scattering 5-25 cm−1) relevant to human organs. The recipe was well tested over broadband (600-1100 nm) range for linearity, reproducibility, homogeneity yielding a robust 4 % coefficient of variation (CV). Finally, we show various applications of the recipe to create standardized matrix phantoms and simply heterogeneous phantoms and anthropomorphic phantoms. The recipe could be exploited to characterize and calibrate the diffuse optical systems and explored for standardization and validation of technologies in Biophotonics.
Characterization of fatty acid binding protein 4 (FABP4) using Raman spectroscopy
Authors: Donjuán-Loredo Guadalupe , Espinosa-Tanguma Ricardo , Ramírez-Elías Miguel
Published: May 2020

FABP4 transports fatty acids and it has been proven to participate in obesity linked diseases, as well as being considered a biomarker of metabolic syndrome. We obtained the Raman spectrum at different concentrations for non-invasive future detection in tissues involved in metabolic syndrome.
Endocardial Mapping of Lesion Delivery to the Human Left Atrium using Near Infrared Spectroscopy
Authors: Singh-Moon Rajinder P. , Park Soo Young , Yang Haiqiu , Hendon Christine P.
Published: May 2020

Current tools for intraprocedural validation of ablation treatment for atrial fibrillation are lacking. In this work, a method is presented for constructing anatomical maps of left atrial lesion deposition using a near-infrared spectroscopy integrated ablation catheter.
Comparison between LC-OCT imaging and histology to quantify the superficial dermis thickness
Authors: Breugnot Josselin , Rouaud-Tinguely Pauline , Pedrazzani Melanie , Cazalas Maxime , Davis Arthur , Bordes Sylvie , Dubois Arnaud , Closs Brigitte
Published: May 2020

The objective was to compare LC-OCT images with histological sections of the same area, in order to validate a new method for in vivo and non-invasive quantification of superficial dermis thickness.
High-throughput, Label-free and Slide-free Histological Imaging by Ultraviolet-excited Autofluorescence
Authors: Zhang Yan , Kang Lei , Li Xiufeng , Terence  , Wong T. W.
Published: May 2020

We proposed a high-throughput label-free and slide-free imaging technique by ultraviolet-excited autofluorescence, assisted by speckle illumination and a deep learning algorithm, to generate subcellular-resolution histology-like images of unprocessed tissues, simplifying the workflow of standard-of-care histopathology.
Evaluation of Neurocognitive Function in Ornithine Transcarbamylase Deficiency
Authors: Anderson Afrouz , Gropman Andrea , Gandjbakhche Amir
Published: May 2020

Hyperammonia due to ornithine transcarbamylase deficiency (OTCD) causes deficiencies in neurocognitive function. Using functional Near Infrared Spectroscopy (fNIRS), our results indicate the inefficient neurocognitive function and hemodynamic variation at low frequency in OTCD.
Contrast-enhanced nonlinear photoacoustic microscopy at 1.7 μm enabled by a high-power gain-switched laser
Authors: Shi Jiawei , Li Can , Wong Kenneth K. Y.
Published: May 2020

We present a contrast-enhanced Grueneisen-relaxation photoacoustic microscopy (GR-PAM) by a home-made high-power thulium-doped fiber laser (TDFL) at 1725 nm. The images of carbon fiber and artery plaque show a significant signal-to-noise (SNR) improvement (over 16dB).
A flexible head fixation system for optical imaging and electrophysiology in awake mice
Authors: Thunemann Martin , Mächler Phillip , Fomin-Thunemann Natalie , Lu Yichen , Liu Xin , Kuzum Duygu , Devor Anna
Published: May 2020

We describe a head fixation system allowing chronic microscopic imaging through cranial windows and optically transparent implanted microelectrode arrays in awake mice.
Exploring the Feasibility of Fiber-Based Speckle Contrast Optical Spectroscopy
Authors: Lin Chenhao P. , Orukari Inema E. , Tracy Christopher , Durduran Turgut , Culver Joseph P.
Published: May 2020

Here we explored the feasibility of using fiber-based speckle contrast optical spectroscopy (SCOS) for flow measurements. We demonstrated the viability of fiber based SCOS for measuring speckle contrast of phantoms and determining the Brownian diffusion coefficient.
Comparison of Continuous Wave and Frequency Domain functional Near Infrared Spectroscopy estimates of Focal Hemodynamic Changes with Finite Element Simulations
Authors: Mohammad Penaz Parveen Sultana , Moka Sadhu , Parthasarathy Ashwin B.
Published: May 2020

Using finite element simulations of photon diffusion, we show that Frequency Domain (FD) and Continuous Wave (CW) Diffuse Optical Spectroscopy provide different estimates of hemodynamic changes due to functional activation.
Joint Spatio-temporal Neural Source Reconstruction Using Electroencephalography and Near-infrared Spectroscopy
Authors: Cao Jiaming , Huppert Theodore , Grover Pulkit , Kainerstorfer Jana M.
Published: May 2020

Electroencephalography (EEG) and near-infrared spectroscopy (NIRS) are commonly used for neural source reconstruction, but have limited spatial or temporal resolution. Using NIRS reconstruction as a spatial prior for EEG reconstruction, neural sources are spatio-temporally reconstructed.
Application of a Two-Layer Model to Correct for Skin Pigmentation in Spatial Frequency Domain Imaging of the Healthy Breast
Authors: Robbins Constance M. , Yang Jason , Antaki James F. , Kainerstorfer Jana M.
Published: May 2020

We describe the extension of a two-layer inverse model for optical property quantification in healthy breast and present a method for optimizing assignment of epidermal absorption coefficient in participants of varying skin tones.
Application of Iterative Reconstruction Technique Based on Sparse Denoising Encoder-Decoder in Mesoscopic Fluorescence Molecules Tomography 3D Reconstruction
Authors: Du Hui , Faulkner Denzel , Yang Fugang
Published: May 2020

To suppress the noise in the measurements for mesoscopic fluorescence molecular tomography, an iterative reconstruction technique via sparse denoising encoder-decoder is presented. Experiments show the preprocessing method can highly improve reconstruction accuracy of tumor bio-probe.
Deep-learning light-field microscopy with improved resolution and reconstruction speed
Authors: Li Guo , Wang Zhaoqiang , Zhang Hao , Zhu Lanxin , Fei Peng
Published: May 2020

We demonstrate a deep-learning based light-field microscopy method, which achieves greatly improved spatial resolution and video-rate reconstruction throughput, thereby allowing sustained volumetric recording of fast biological dynamics at high spatiotemporal resolution.
Quantitative assessment of intestinal fibrosis in vivo with spectroscopic and strain by endoscopic photoacoustic imaging
Authors: Xu Guan , Lei Hao , Zhu Yunhao , Ni Linyu , Johnson Laura , Eaton Kate , Rubin Jonathan , XuedingWang  , Higgins Peter
Published: May 2020

This study investigates on the molecular and mechanical markers of intestinal fibrosis in Crohn’s Disease using endoscopic photoacoustic imaging. The quantitative imaging results in vivo are validated by histology and microelastometry.
Broadband extraction of tissue optical properties using a portable hybrid time-resolved continuous wave instrumentation: characterization of ex vivo organs
Authors: Nogueira Marcelo Saito , Lacerenza Michele , Sekar Sanathana Konugolu Venkata , Buttafava Mauro , Pifferi Antonio , Tosi Alberto , Contini Davide , Andersson-Engels Stefan
Published: May 2020

Successful demonstration of a unique portable CW-TDDOS system for accurate and multiwavelength retrieval of tissue optical properties. Determining these properties has potential to improve the diagnosis and treatment outcomes in clinical and sports settings.
Characterizing Treatment Response of Pancreatic Tumor Patient-Derived Xenografts in Mice by Simultaneous Label-Free Autofluorescence Multi-Harmonic (SLAM) Microscopy
Authors: Park Jaena , Chaney Eric , You Sixian , Abdelrahman Amro M. , Leiting Jennifer L. , Yonkus Jennifer A. , Groves Peter D. , Harrington Jonathan J. , Spillman Darold R. , Lynch Isaac T. , Marjanovic Marina , Tu Haohua , Bushell Colleen B. , Nelson Heidi , Truty Mark J. , Boppart Stephen A.
Published: May 2020

Simultaneous label-free autofluorescence multi-harmonic (SLAM) microscopy images of treated and non-treated mice with xenografts derived from human pancreatic tumors were acquired and analyzed for evaluation of chemotherapeutic drug response.
Dual-modality Photoacoustic and Ultrasound Imaging for Assessing Treatment Response in Colorectal Cancer: a pilot study
Authors: Zhu Quing , Leng Xiandong , Uddin K M Shihab , Chapman William , Luo Hongbo , Kou Sitai , Amidi Eghbal , Yang Guang , Mutch Matthew
Published: May 2020

We present a handheld co-registered acoustic-resolution photoacoustic endoscope and ultrasound system and initial clinical results using the system and a neural network to predict rectal cancer chemoradiation treatment response.
Tissue Oxygenation Measurements using a Non-Contact, Smartphone-based Near-Infrared Optical Device
Authors: Kaile Kacie , Fernandez Christian , Godavarty Anuradha
Published: May 2020

A non-contact smartphone based NIR imaging device has been developed to measure 2D spatio-temporal tissue oxygenation maps. Preliminary in-vivo studies demonstrated the ability of this device to observe oxygenation changes in response to occlusion.
Clinical Photoacoustic/Ultrasound Imaging: Systems and Applications
Authors: Kim Jeesu , Park Eun-Yeong , Choi Wonseok , Park Byullee , Lee Ki Jong , Kim Chulhong
Published: May 2020

We have successfully developed a real-time clinical photoacoustic and ultrasound imaging system which enables us to optimize the imaging parameters seamlessly. The system is greatly favorable for clinical research.
Leveraging Surface Hsp90 Expression for Rapid-on-site Breast Cancer Diagnostics
Authors: Wang Roujia , Deutsch Riley , Alvarez Daniel A. , Lam Christopher , Crouch Brian T. , Haystead Timothy , Ramanujam Nimmi
Published: May 2020

We developed a portable, low-cost, handheld fluorescent microscope to perform rapid heat shock protein 90 (Hsp90) molecular imaging. The source of non-specific signal and diffusion kinetics of the probe is studied.
Ensemble deep learning for breast cancer segmentation in optical coherence tomography (OCT) images
Authors: Mojahed Diana , Lye Theresa , Bareja Rohan , Hibshoosh Hanina , Hendon Christine
Published: May 2020

An ensemble deep learning technique was developed for segmenting breast cancer in optical coherence tomography (OCT) images from two imaging systems and is trained on B-scan and en-face images to yield improved predictions.
Development of a Prototype of a Wearable Flexible Electro-Optical Imaging System for the Breast
Authors: Wang Fay , Kim Youngwan , Altoe Mirella , Marone Alessandro , Trippeer Barbara , Edwards Anastasia , Sperber Amy , Goetz Susanne , Schiros Theanne , Kymissis Ioannis , Hielscher Andreas H.
Published: May 2020

We have developed a fully wearable breast imaging system by combining a garment and a flexible electronic system. A test on a human subject shows the system’s potential for monitoring cancer treatment with a comfortable patient-interface.
Laser Speckle Micro-rheology for biomechanical mapping of breast carcinoma
Authors: Hajjarian Zeinab , Brachtel Elena , Tshikudi Diane , Nadkarni Seemantini
Published: May 2020

We introduce a novel technology, termed laser speckle micro-rheology (LSM) that offers the unique capability to map the viscoelastic properties of the tissue microenvironment. This innovation will provide important insight into mechano-biology of disease progression.
A Chest Shield to Be Used in Phototherapy for Jaundice
Authors: Mitrou Androniki , Iorizzo Tyler , Gomes Cheryl , Mannan Javed , Yaroslavsky Anna
Published: May 2020

Through optical and thermal properties testing, we evaluated four biocompatible and two reflective materials to propose a two-layer chest shield design for neonates undergoing phototherapy for jaundice.
Towards translation of advanced laser scanning microscopy for sentinel lymph node diagnostics focusing on melanoma metastases
Authors: Kantere Despoina , Bagge Roger Olofsson , Wennberg Ann-Marie , Ericson Marica B.
Published: May 2020

A descriptive study exploring the potential of multiphoton microscopy for sentinel lymph node diagnostics in melanoma, which reveals cell morphology characteristics in tissue from lymph node metastasis. Future studies are encouraged to promote translational implementation.
A flexible electronic optical imaging system for detection of arthritis in patient with systemic lupus erythematosus
Authors: Kim Youngwan , Marone Alessandro , Danias George , Chen Tommy K. , Tang Wei , Kim Hyun K. , Askanase Anca D. , Kymissis Ioannis , Hielscher Andreas H.
Published: May 2020

We have developed a wearable flexible optical imaging system (We-FOIS) that employs dynamic diffuse optical tomography (dDOT) for assessing arthritis in patients with systemic lupus erythematosus (SLE).
Development of a cost effective optical imaging system for monitoring of Rheumatoid Arthritis
Authors: Rowley George , Lighter Daniel , Dehghani Hamid
Published: May 2020

Rheumatoid Arthritis (RA) affects a significant portion of the population, but early treatment can improve patient outcomes. A low-cost, streamlined system has been developed for monitoring the progression of RA and inform treatment during this critical early window.
Point-of-care test for early-stage Lyme disease using a multiplexed paper-based assay and machine learning
Authors: Joung Hyou-Arm , Ballard Zachary S. , Wu Jing , Tseng Derek K. , Teshome Hailemariam , Zhang Linghao , Dattwyler Raymond J. , Arnaboldi Paul M. , Garner Omai , Di Carlo Dino , Ozcan Aydogan
Published: May 2020

We report a multiplexed paper-based assay powered by mobile imaging and machine learning for point-of-care diagnosis of Lyme Disease. Blind testing of 96 serum samples showed a sensitivity and specificity of 85.7% and 96.3%, respectively.
Rapid Detection of Histophilus somni by a Nanomaterial Optical Fiber Biosensor Assay
Authors: Bandara A.B. , Zuo Z. , McCutcheon K. , Ramachandran S. , Inzana T. , Heflin J.R.
Published: May 2020

We demonstrate a method for rapid (<1 hour) identification of as few as 100 cells of bacteria such as H. somni using a long-period grating with a surface layer of ionic self-assembled multilayers and DNA probe.
High Optode-density Wearable Probe for Monitoring Breast Tumor Dynamics during Neoadjuvant Chemotherapy
Authors: Spink Sam , Teng Fei , Pera Vivian , Peterson Hannah , Eggebrecht Adam , Ko Naomi , Roblyer Darren
Published: May 2020

We present a high-optode density continuous-wave (CW) wearable diffuse optical device for the investigation of hemodynamic responses of locally advanced breast tumors. Initial results from tissue-simulating phantoms and a normal volunteer study are described.
In vivo metabolic imaging reveals mitochondrial membrane potential reprogramming following Her2-targeted therapy and dormant disease
Authors: Madonna Megan C. , Duer Joy , Fox Doug , Alvarez James , Ramanujam Nirmala
Published: May 2020

We performed in intravital fluorescent microscopy in a preclinical cancer dormancy model to capture key changes in mitochondrial activity associated with Her2 treated breast cancer both acutely and in a residual disease state.
Tissue Oxygenation Changes in Response to Radiation Therapy in Breast Cancer Subjects Using Near-Infrared Optical Imaging
Authors: Robledo Edwin , Leiva Kevin , Beiner Corina , Murillo Juan , Rodrigues Maria Amelia , Chuong Michael , Wu Wensong , Godavarty Anuradha
Published: May 2020

Tissue oxygenation changes in response to radiation therapy in breast cancer subjects,
with decreased oxygen saturation due to onset of radiation dermatitis, as observed via near-infrared
optical imaging studies.
Parallel Coupled Double Ring Resonator configuration of for Breast Cancer Cell Detection
Authors: Ali Liaquat , Mohammed Mahmood Uddin , Chowdhury Masud H
Published: May 2020

A parallel coupled two-ring resonator in cascaded configuration integrated with coupling linear waveguide is proposed as a label-free biosensor for breast cancer cell detection. The parameters of ring resonator are characterized to demonstrate high-quality factors.