bluuebunny/crossref_metadata_2025 huggingface dataset:
Reconstruction of Craniomaxillofacial Bone Defects with 3D-Printed Bioceramic Implants: Scoping Review and Clinical Case Series
Authors: Verbist Maarten , Vandevelde Anne-Laure , Geusens Joris , Sun Yi , Shaheen Eman , Willaert Robin
Published: May 2024

Reconstruction of craniomaxillofacial bone defects using 3D-printed hydroxyapatite (HA) bioceramic patient-specific implants (PSIs) is a new technique with great potential. This study aimed to investigate the advantages, disadvantages, and clinical outcomes of these implants in craniomaxillofacial surgeries. The PubMed and Embase databases were searched for patients with craniomaxillofacial bone defects treated with bioceramic PSIs. Clinical outcomes such as biocompatibility, biomechanical properties, and aesthetics were evaluated and compared to those of commonly used titanium or poly-ether-ether-ketone (PEEK) implants and autologous bone grafts. Two clinical cases are presented to illustrate the surgical procedure and clinical outcomes of HA bioceramic PSIs. Literature review showed better a biocompatibility of HA PSIs than titanium and PEEK. The initial biomechanical properties were inferior to those of autologous bone grafts, PEEK, and titanium but improved when integrated. Satisfactory aesthetic results were found in our two clinical cases with good stability and absence of bone resorption or infection. Radiological signs of osteogenesis were observed in the two clinical cases six months postoperatively. HA bioceramic PSIs have excellent biocompatible properties and imitate natural bone biomechanically and radiologically. They are a well-suited alternative for conventional biomaterials in the reconstruction of load-sharing bone defects in the craniomaxillofacial region.
Dose Optimization of Intravenous Indocyanine Green for Malignant Lung Tumor Localization
Authors: Ujiie Hideki , Chiba Ryohei , Sasaki Akihiro , Nomura Shunsuke , Shiiya Haruhiko , Otsuka Shohei , Yamasaki Hiroshi , Fujiwara-Kuroda Aki , Ohtaka Kazuto , Aragaki Masato , Okada Kazufumi , Ebihara Yuma , Kato Tatsuya
Published: May 2024

Background: Intravenously administered indocyanine green (ICG) accumulates in lung tumors, facilitating their detection via a fluorescence spectrum measurement. This method aids in identifying tumor locations that are invisible to the naked eye. We aim to determine the optimal ICG dose and administration method for accurate tumor identification during lung resection surgeries, utilizing a novel ICG fluorescence spectroscopy system for precise tumor localization. Materials and Methods: ICG should be dissolved in the provided solution or distilled water and administered intravenously approximately 24 h before surgery, beginning with an initial dose of 0.5 mg/kg. If the tumor detection rate is insufficient, the dose may be gradually increased to a maximum of 5.0 mg/kg to determine the optimal dosage for effective tumor detection. This fluorescence spectroscopy during surgery may reveal additional lesions that remain undetected in preoperative assessments. The primary endpoint includes the correct diagnostic rate of tumor localization. The secondary endpoints include the measurement of the intraoperative ICG fluorescence spectral intensity in lung tumors, the assessment of the operability and safety of intraperitoneal ICG administrations, the measurement of the ICG fluorescence spectral intensity in surgical specimens, the comparison of the spectral intensity in lung tissues during collapse and expansion, the correlation between ICG camera images and fluorescence spectral intensity, and the comparison of fluorescence analysis results with histopathological findings. The trial has been registered in the jRCT Clinical Trials Registry under the code jRCTs011230037. Results and Conclusions: This trial aims to establish an effective methodology for localizing and diagnosing malignant lung tumors, thereby potentially improving surgical outcomes and refining treatment protocols.
Comparison of Post-Operative Outcomes of Right Colectomy between Crohn’s Disease and Adenocarcinoma of the Right Colon: A Retrospective Cohort Study
Authors: Bursztyn Naama , Slomowitz Edden , Assaf Dan , Yahia Ehab Haj , Kent Ilan , Wasserberg Nir , Avital Shmuel , White Ian
Published: May 2024

(1) Background: Crohn’s disease (CD) and right-sided colorectal-carcinoma (CRC) are two common indications for right colectomies. Many studies have tried to identify risk factors associated with post-operative complications for both CD and CRC. However, data directly comparing the outcomes of the two are sparse. This study aims to compare the 30-day post-operative outcome after a right colectomy for CD versus CRC. Its secondary aim is to identify the factors associated with these outcomes for each group. (2) Methods: A retrospective cohort study of 123 patients who underwent a right colectomy for CD or CRC in a single institution between March 2011 and March 2016. (3) Results: There were no significant differences between the groups when comparing the overall complication rate, the median Clavien–Dindo score, reoperation rates and the length of hospitalization. The leak rate was higher in the Crohn’s group (13.95% (6/43) vs. 3.75% (3/80)), p = 0.049), although the stoma rate was the same (4/43 9.5%; 7/80 9.9%). (4) Conclusions: This study has shown that post-operative complication rate is similar for right colectomy in CD and CRC. However, Crohn’s disease patients did have a higher leak rate.
Oceanographic Research in the Thermaikos Gulf: A Review over Five Decades
Authors: Androulidakis Yannis , Makris Christos , Kombiadou Katerina , Krestenitis Yannis , Stefanidou Natassa , Antoniadou Chryssanthi , Krasakopoulou Evangelia , Kalatzi Maria-Ignatia , Baltikas Vasilis , Moustaka-Gouni Maria , Chintiroglou Chariton Charles
Published: May 2024

The Thermaikos Gulf (TG) is a semi-enclosed, river-influenced, marine system situated in the eastern Mediterranean Sea, sustaining both urban coastal regions and ecologically preserved natural areas. Facing a plethora of environmental and anthropogenic pressures, the TG serves as a critical nexus where human activities intersect with marine ecosystems. The quality and health of the TG’s marine environment are tightly linked to the socioeconomic activities of the coastal communities comprising approximately 1.5 million inhabitants. The main features of the TG’s environmental dynamics and ecological status have been scrutinized by dedicated research endeavors during the last 50 years. This review synthesizes the seminal findings of these investigations, offering an evaluation of their contribution to research, their present collective impact, and their trajectory toward the future. A severe deterioration of the TG’s environmental quality was detected in the 1970s and 1980s when the treatment of urban wastewater was completely absent. A steady trend of recovery was observed after the 1990s; however, so far, the goal of a “good environmental state” mandated by national legislation and European directives has not been achieved. A clear reduction in research was detected after 2010, associated with the recession of the Greek economy, following the “golden period” for research in the TG from the mid-1990s until the late 2000s. The most important research gaps and uncertainties are discussed, while specific targeted recommendations for the improvement of monitoring and understanding of the physical, biochemical, and ecological state of the gulf are provided: (i) increase in permanent observational stations (temporally and spatially); (ii) inclusion of all major environmental parameters; (iii) monitoring of the quantity and quality of all land-originated freshwater discharges; (iv) monitoring and management of important aspects of the marine environment that have received minimal attention in the past (e.g., coastal erosion, plastic pollution); (v) development of accurate prediction tools (e.g., numerical techniques) to support first-level responders and efficient management; (vi) establishment of a supervising public entity that would support the holistic overview and management of the entire TG. These suggestions are directed at overcoming the existing uncertainties in the knowledge of the TG, safeguarding its ecological integrity and its role as a crucial link to marine biodiversity and sustainability in the Mediterranean basin.
How Generative AI Is Transforming Journalism: Development, Application and Ethics
Authors: Shi Yi , Sun Lin
Published: May 2024

Generative artificial intelligence (GAI) is a technology based on algorithms, models, etc., that creates content such as text, audio, images, videos, and code. GAI is deeply integrated into journalism as tools, platforms and systems. However, GAI’s role in journalism dilutes the power of media professionals, changes traditional news production and poses ethical questions. This study attempts to systematically answer these ethical questions in specific journalistic practices from the perspectives of journalistic professionalism and epistemology. Building on the review of GAI’s development and application, this study identifies the responsibilities of news organizations, journalists and audiences, ensuring that they realize the potential of GAI while adhering to journalism professionalism and universal human values to avoid negative technological effects.
Inflammatory Biomarkers for Assessing In-Hospital Mortality Risk in Severe COVID-19—A Retrospective Study
Authors: Bimbo-Szuhai Erika , Botea Mihai Octavian , Romanescu Dana Diana , Beiusanu Corina , Gavrilas Gabriela Maria , Popa Georgiana Maria , Antal Dania , Bontea Mihaela Gabriela , Sachelarie Liliana , Macovei Iulia Codruta
Published: May 2024

(1) Background: Our study aims to investigate the utility of inflammatory factors as prognostic indicators for disease severity and mortality in COVID-19 patients admitted to the Intensive Care Unit (ICU) Department of Pelican Clinical Hospital Oradea Romania. While elevated white blood cell (WBC) levels are associated with COVID-19 severity and mortality, they may not effectively predict the risk of death; (2) Methods: In our ICU department, we conducted assessments on the 10th and 14th days of COVID-19 patients’ hospitalization, measuring the following markers: C-reactive protein (CRP) levels, procalcitonin (PCT) levels, granulocytes/lymphocytes (G/L) ratios, ferritin levels, age, and obesity status. We included a total of 209 eligible COVID-19 patients in the final analysis. Our goal was to identify biomarkers that could quickly identify high-risk patients with a potential for disease progression and mortality; (3) Results: Our study (a retrospective, single-center observational cohort study) demonstrated statistically significant differences in predicting mortality and disease severity based on G/L ratio (p < 0.0001), PCT (p < 0.0002), CRP (p < 0.0001), ferritin (p < 0.0001), age (p < 0.0001), and obesity (p < 0.0001); (4) Conclusions: Having a G/L ratio exceeding 20 units, along with elevated levels of PCR, PCT, and ferritin in older and obese patients on the 3rd day of ICU admission, represents significant risk factors for in-hospital mortality in severe COVID-19 patients.
Histologic Disease Persists beyond Mucosal Healing and Could Predict Reactivation in Ulcerative Colitis
Authors: Laterza Lucrezia , Piscaglia Anna Chiara , Bibbò Stefano , Arena Vincenzo , Brisigotti Massimo , Fabbretti Giovanna , Stefanelli Maria Loredana , Cesario Valentina , Maresca Rossella , Poscia Andrea , Pugliese Daniela , Gaetani Eleonora , Papa Alfredo , Cammarota Giovanni , Armuzzi Alessandro , Gasbarrini Antonio , Scaldaferri Franco
Published: May 2024

Mucosal healing (MH) is the main target in ulcerative colitis (UC) treatment. Even if MH lowers the risk of disease reactivation, some patients still relapse. Histologic activity (HA) beyond MH could explain these cases. This study aims to assess how many patients with MH have HA and which lesions are associated with relapse. We retrospectively enrolled UC patients showing MH, expressed as a Mayo Endoscopic Subscore (MES) of 0 and 1 upon colonoscopy. We reviewed the histological reports of biopsies evaluating the presence of typical lesions of UC and assessed the number of clinical relapses after 12 months. Among 100 enrolled patients, 2 showed no histological lesions. According to univariate analysis, patients with a higher number of histological lesions at the baseline had a higher risk of relapse (OR 1.25, p = 0.012), as well as patients with basal plasmacytosis (OR 4.33, p = 0.005), lamina propria eosinophils (OR 2.99, p = 0.047), and surface irregularity (OR 4.70, p = 0.010). However, in the multivariate analysis, only basal plasmacytosis (OR 2.98, p = 0.050) and surface irregularity (OR 4.50, p = 0.024) were confirmed as risk factors for disease reactivation. HA persists in a significant percentage of patients with MH. Despite the presence of MH, patients with basal plasmacytosis and surface irregularity have a higher risk of relapse.
Research on B2C Cross-Border Electronic Commerce Return Logistics Model Selection Based on Estimated Return Rate
Authors: Li Yi , Li Zhiyang
Published: May 2024

This paper investigates the estimated return rate and optimal order quantity under three cross-border e-commerce return logistics modes: direct mail (from predecessor), in situ destruction (new), and insurance (new). The estimated return rate under each model was analyzed and it was found that different modes have different thresholds in delivery lead time (the time retailers need to deliver goods to customers), and within which the estimated return rate increases as the delivery lead time increases. And a size comparison of the estimated return rates for the three models was conducted. A profit model was constructed based on the estimated return rate model, the optimal order quantity was calculated, and the effects of different factors (tax, postage, and delivery lead time etc.) on it were analyzed. For the insurance model, the effect of bearing the insurance ratio between retailers and consumers on the optimal order quantity was examined. The goal of this paper was to construct a model of the estimated return rate for the two new modes and to compare the estimated return rate of the three modes, which provides a reference for retailers to choose among the diversified return logistics modes and then make the best ordering strategy according to the influence of different factors on the optimal order quantity.
Farm Household Vulnerability Due to Land and Forest Fire in Peatland Areas in South Sumatra
Authors: Yazid Muhammad , Adriani Dessy , Riswani  , Damayanthy Dini
Published: May 2024

Land and forest fires in peatland areas in Indonesia have a widespread negative impact on surrounding communities. Possible vulnerabilities relate to economic, social, ecological, livelihoods, and environmental vulnerability. This study aimed to assess household vulnerability due to land and forest fires in peatland areas in Ogan Komering Ilir District in South Sumatra and observe changes in peat ecosystems in those areas. The study was conducted in three peatland hydrological units (PHUs)—(1) PHU Sungai Sugihan–Sungai Lumpur; (2) PHU Sungai Sibumbung–Sungai Batok; and (3) PHU Sungai Saleh–Sungai Sugihan—covering 300 households as samples. Primary data were collected through structured interviews and analyzed descriptively. The analysis revealed the following: (1) PHU Sungai Sibumbung–Sungai Batok had the highest score for livelihood vulnerability and climate change but the lowest score for social, economic, and ecological vulnerability; (2) PHU Sungai Saleh–Sungai Sugihan had the highest score for economic and ecological vulnerability but the lowest score for livelihood vulnerability; (3) PHU Sungai Sugihan–Sungai Lumpur had the highest score for social vulnerability but lowest score for climate change vulnerability; and (4) the number of household members, toddlers, and elderly, and all economic indicators except land ownership, contributed relatively similarly to social vulnerability in all PHUs.
Advancements in Biochar Modification for Enhanced Phosphorus Utilization in Agriculture
Authors: Ahmed Nazir , Deng Lifang , Wang Chuan , Shah Zia-ul-Hassan , Deng Lansheng , Li Yongquan , Li Juan , Chachar Sadaruddin , Chachar Zaid , Hayat Faisal , Bozdar Bilquees , Ansari Filza , Ali Rashid , Gong Lin , Tu Panfeng
Published: May 2024

The role of modified biochar in enhancing phosphorus (P) availability is gaining attention as an environmentally friendly approach to address soil P deficiency, a global agricultural challenge. Traditional phosphatic fertilizers, while essential for crop yield, are costly and environmentally detrimental owing to P fixation and leaching. Modified biochar presents a promising alternative with improved properties such as increased porosity, surface area, and cation exchange capacity. This review delves into the variability of biochar properties based on source and production methods and how these can be optimized for effective P adsorption. By adjusting properties such as pH levels and functional groups to align with the phosphate’s zero point of charge, we enhance biochar’s ability to adsorb and retain P, thereby increasing its bioavailability to plants. The integration of nanotechnology and advanced characterization techniques aids in understanding the structural nuances of biochar and its interactions with phosphorus. This approach offers multiple benefits: it enables farmers to use phosphorus more efficiently, reducing the need for traditional fertilizers and thereby minimizing environmental impacts, such as greenhouse gas emissions and P leaching. This review also identifies existing research gaps and future opportunities for further biochar modifications. These findings emphasize the significant potential of modified biochar in sustainable agriculture.
Differential Analysis of Carbon Emissions between Growing and Shrinking Cities: A Case of Three Northeastern Provinces in China
Authors: Song Yuanzhen , Tian Jian , He Weijie , Namaiti Aihemaiti , Zeng Jian
Published: May 2024

Carbon emission issues are becoming increasingly severe, and the carbon emissions in shrinking cities, primarily characterized by population loss, are often overlooked and insufficiently studied. This paper focuses on the carbon emissions from county-level administrative units in China’s three northeastern provinces from 2001 to 2017. The study scientifically identified shrinking cities and measured the differences in carbon emission characteristics between growing and shrinking cities using the Theil index. Ultimately, the paper constructs a panel spatial econometric model to analyze the factors influencing them and explore their spatial effects. (1) The total carbon emissions in the Three Northeastern Provinces exhibited an inverted U-shaped trend, increasing from 734.21 million tons in 2001 to 1731.73 million tons in 2017, with the Mann–Kendall trend test showing a significant increase; spatially, this manifests as a significant positive spatial autocorrelation. (2) The region has 138 shrinking cities, accounting for over 50%; regarding carbon emission characteristics, the Theil index has consistently remained above 0.18, indicating significant differences between the carbon emissions of growing and shrinking cities. (3) The panel spatial econometric model results show that the influencing factors of carbon emissions in shrinking cities have unique directions, intensities, and spatial effects. In shrinking cities, aside from localized GDP effects and per-capita GDP acting as a suppressant, the population size has a pronounced inhibitory effect on local and surrounding carbon emissions. The analysis reveals significant differences in the carbon emission patterns and mechanisms between growing and shrinking cities; based on these results, the paper proposes differentiated carbon control strategies.
Missing Landscapes: A Geohistory of Parkland Landscapes in Northwestern Morocco
Authors: Ballouche Aziz
Published: May 2024

Northwestern Morocco is characterized by highly anthropized landscapes under the combined effect of agricultural intensification, resource overexploitation, urbanization, and tourism, but also local reforestation. Reconstructing the recent changes in vegetation in the region of the lower valley of the Loukkos river near Larache and their relationship to the settlement history are particularly helpful for understanding the processes at work within the landscape construction. The geohistorical approach combines paleoenvironmental, documentary, and historical data. The last few centuries have seen the emergence of wooded stands, in which cork oaks are a structural element. As forests were retreating, parklands intended for agriculture, agroforestry, and herding, like the Spanish dehesa and Portuguese montado, began to emerge. Nearly all of them have disappeared today, but we can identify their legacy and evaluate their cultural significance through comparing them with their counterparts in the Iberian Peninsula, but also in other areas of Morocco. Their deep historical roots give this landscape an evolving heritage character that is directly linked to the communities’ lifestyles, culture, and history.
Linking Land Use and Land Cover Changes and Ecosystem Services’ Potential in Natura 2000 Site “Nordul Gorjului de Vest” (Southwest Romania)
Authors: Popescu Simona Mariana , Mititelu-Ionuș Oana , Ștefănescu Dragoș Mihail
Published: May 2024

Considering that land use and land cover (LULC) change is one of the most important challenges to biodiversity today, we used Copernicus products to analyze LULC changes at the level of the “Nordul Gorjului de Vest” Natura 2000 site (Romania) from 1990 to 2018. The interpretation of the impact of these changes on areas with very high potential for three regulating ecosystem services (ESs) (local climate regulation, regulation of waste, and water purification) was performed. Forest habitats are the major LULC class category in the “Nordul Gorjului de Vest” Natura 2000 site, with broad-leaved forest as the dominant forest class. In terms of areas lost or gained by the different LULC classes for each analyzed time interval, most transformations took place in the period 2000–2006, changes which were also reflected in the overall study period (1990–2018). During this time frame, the conversion of transitional forest shrubs into broad-leaved forest, which is the second largest transition in terms of absolute area changed, led, in terms of contribution rates, to an increase in the areas with very high potential for two of the three analyzed ESs. The conversion of transitional woodland shrub into broad-leaved forest was conductive only to synergy for all the pairwise interactions between the three ESs.
Eosinophilic Dermatoses: Cause of Non-Infectious Erythema after Volume Replacement with Diced Acellular Dermal Matrix in Breast Cancer?
Authors: Schneider Jean , Lim Seung Taek , Yi An Yeong , Suh Young Jin
Published: May 2024

Introduction: Non-infectious erythema, or Red Breast Syndrome (RBS), has been observed on the skin where acellular dermal matrix was implanted, although the exact cause is yet to be determined. Patients and Methods: A total of 214 female patients underwent breast-conserving surgery (BCS) and volume replacement using diced acellular dermal matrix (dADM) for breast cancer between December 2017 and December 2018. After collecting and evaluating relevant clinical data, inflammation markers, along with NK cell status presented by IFN-γ secretion assay, were measured using ELISA. Results: Nineteen patients (8.88%) presented with RBS after BCS and dADM use. A significant increase of platelet-to-lymphocyte ratio was noted in the non-RBS group (p = 0.02). Compared to the RBS group (p = 0.042), the WBC level of the non-RBS group showed significant decrease over time. Eosinophil counts increased significantly at follow-up but went up higher in the RBS group. Multivariate analysis showed preoperative chemotherapy significantly increased the hazard of RBS (OR 3.274, p = 0.047 and OR 17.098, p < 0.001, respectively). Discussion: Though no causal relationship between RBS and immune status was proven, the results suggest an association between preoperative chemotherapy and RBS in addition to the possible role of eosinophilia in leading to eosinophilic dermatoses, which warrants further exploration and elucidation.
Cytotoxic Activity of the Red Grape Polyphenol Resveratrol against Human Prostate Cancer Cells: A Molecular Mechanism Mediated by Mobilization of Nuclear Copper and Generation of Reactive Oxygen Species
Authors: Farhan Mohd
Published: May 2024

Resveratrol, a polyphenolic compound found primarily in red grapes and pomegranates is known as an antioxidant but can act as a pro-oxidant when copper ions are present. Here, resveratrol is demonstrated to reduce cell growth (as evaluated by MTT assay) and promote apoptosis-like cell death (as measured by Histone/DNA ELISA) in prostate cancer cell lines PC3 and C42B. This effect is effectively inhibited by a copper chelator (neocuproine) and reactive oxygen species (ROS) scavengers (thiourea for hydroxyl radical, superoxide dismutase for superoxide anion, and catalase for hydrogen peroxide). These inhibitory effects provide evidence that intracellular copper reacts with resveratrol within cancer cells, resulting in DNA damage via the generation of reactive oxygen species. Additionally, it has been demonstrated that non-tumorigenic epithelial cell lines (MCF-10A) grown in media supplemented with copper are more susceptible to growth inhibition by resveratrol, as confirmed by the observed reduction in cell proliferation. Copper supplementation induces enhanced expression of the copper transporter CTR1 in MCF-10A cells, which is reduced by the addition of resveratrol to the media. The selective cell death of cancer cells generated by copper-mediated and ROS mechanisms may help to explain the anticancer properties of resveratrol.
A Sole Case of the FGF23 Gene Mutation c.202A>G (p.Thr68Ala) Associated with Multiple Severe Vascular Aneurysms and a Hyperphosphatemic Variant of Tumoral Calcinosis—A Case Report
Authors: Ivanova Nevena Georgieva
Published: May 2024

Tumoral calcinosis is an extremely rare genetic disease caused by mutations in three genes, GALNT3, FGF23, and KL, which disrupt phosphorus metabolism. The hallmark of this condition is the formation of tumors in the soft tissues around the joints. Other phenotypic features of tumoral calcinosis are dental involvement and brain and vascular calcifications. The clinical case reported herein presents for the first time to the scientific community the c.202A>G (p.Thr68Ala) mutation of the FGF23 gene, associated with a hyperphosphatemic variant of tumoral calcinosis and multiple severe vascular aneurysms. A female patient underwent multiple surgeries for tumor formations in her soft tissues that first appeared at the age of 12 months. On this occurrence, the patient was found to have hyperphosphatemia, low phosphate clearance, increased tubular reabsorption with normal levels of total and ionized calcium, vitamin D3, and parathyroid hormone, and no effect of treatment with sevelamer hydrochloride and a low-phosphate diet. At the age of 39, the patient underwent imaging studies due to edema and a pulsating formation in the neck area, which revealed multiple vascular aneurysms with thrombosis, for which she received operative and interventional treatment. In this connection, and because of the established phosphorus metabolism disturbance, a genetic disease was suspected. The sequence analysis and deletion/duplication testing of the 358 genes performed on this occasion revealed that the woman was homozygous for a variant of the c.202A>G (p.Thr68Ala) mutation of the FGF23 gene. The established mutation is not present in population databases. The presented clinical case is the first and only one in the world to demonstrate the role of this type of FGF23 gene mutation in the development of a hyperphosphatemic variant of tumoral calcinosis characterized by aggressive formation of multiple vascular aneurysms.
Imipenem/Cilastatin/Relebactam for Complicated Infections: A Real-World Evidence
Authors: Sansone Pasquale , Giaccari Luca Gregorio , Di Flumeri Giusy , Pace Maria Caterina , Pota Vincenzo , Coppolino Francesco , Brunetti Simona , Aurilio Caterina
Published: May 2024

(1) Background: Infections caused by multidrug-resistant (MDR) bacteria represent one of the major global public health problems of the 21st century. Beta-lactam antibacterial agents are commonly used to treat infections due to Gram-negative pathogens. New β-lactam/β-lactamase inhibitor combinations are urgently needed. Combining relebactam (REL) with imipenem (IMI) and cilastatin (CS) can restore its activity against many imipenem-nonsusceptible Gram-negative pathogens. (2) Methods: we performed a systematic review of the studies reporting on the use of in vivo REAL/IPM/CS. (3) Results: A total of eight studies were included in this review. The primary diagnosis was as follows: complicated urinary tract infection (n = 234), complicated intra-abdominal infections (n = 220), hospital-acquired pneumonia (n = 276), and ventilator-associated pneumonia (n = 157). Patients with normal renal function received REL/IPM/CS (250 mg/500 mg/500 mg). The most frequently reported AEs occurring in patients treated with imipenem/cilastatin plus REL/IPM/CS were nausea (11.5%), diarrhea (9.8%), vomiting (9.8%), and infusion site disorders (4.0%). Treatment outcomes in these high-risk patients receiving REL/IPM/CS were generally favorable. A total of 70.6% of patients treated with REL/IPM/CS reported a favorable clinical response at follow-up. (4) Conclusions: this review indicates that REL/IPM/CS is active against important MDR Gram-negative organisms.
Is It Possible to Train the Endothelium?—A Narrative Literature Review
Authors: Biernat Karolina , Kuciel Natalia , Mazurek Justyna , Hap Katarzyna
Published: May 2024

This review provides an overview of current knowledge regarding the adaptive effects of physical training on the endothelium. The endothelium plays a crucial role in maintaining the health of vessel walls and regulating vascular tone, structure, and homeostasis. Regular exercise, known for its promotion of cardiovascular health, can enhance endothelial function through various mechanisms. The specific health benefits derived from exercise are contingent upon the type and intensity of physical training. The review examines current clinical evidence supporting exercise’s protective effects on the vascular endothelium and identifies potential therapeutic targets for endothelial dysfunction. There is an urgent need to develop preventive strategies and gain a deeper understanding of the distinct impacts of exercise on the endothelium.
Synergistic Effect of Acrylate of Dialkyl Dithiophosphoric Acid Combined with Molybdenum Dialkyl Dithiocarbamate as Additives in Gear Oil
Authors: Ding Minghao , Mo Yimin , Zhang Hong , Liu Qingchun
Published: May 2024

With the aim of improving the tribological properties of low-viscosity gear oil for automobiles, an acrylate of dialkyl dithiophosphoric acid (ADDP) with strong polar groups was synthesized. The tribological behavior of ADDP combined with molybdenum dialkyl dithiocarbamate (MoDTC) in gear oil was systematically studied. Tribological performances of gear oil containing different additives were assessed using a four-ball friction and wear tester. The obtained tribological characteristics reveal that ADDP and MoDTC can significantly improve the antiwear and antifriction performance of low-viscosity gear oil. Moreover, compared with using MoDTC or ADDP alone, the average friction coefficient and wear scar diameter of ADDP combined with MoDTC further decreased by 2.41–19.15% and 5.00–18.19%, respectively. Analysis of the worn surface showed that the structural characteristics and physical synergistic lubricating actions of the ADDP with MoDTC additives during the friction process can contribute to the exceptional tribological properties of the hybrid additives.
Numerical Investigations of Static and Dynamic Characteristics of a Novel Staggered Labyrinth Seal with Semi-Elliptical Structure
Authors: Yan Shebin , Ye Zhifeng , Wang Dezhao , Su Huihao , Zhou Wenjie
Published: May 2024

In order to optimize sealing performance, a novel labyrinth seal with semi-elliptical teeth (SET) structure is proposed in this paper, which includes semi-elliptical teeth and a series of cavities. The simulation results calculated by the numerical methods are compared with the experimental and theoretical results, and static and dynamic characteristics of the novel SET structure are further investigated. The numerical simulations of labyrinth seals with the SET structure demonstrate high accuracy and reliability, with a maximum relative error of less than 6% as compared to experimental results, underscoring the validity of the model. Notably, leakage rates are directly influenced by pressure drop and axial offset, with optimal sealing achieved at zero axial displacement. The direct damping coefficient increases as the pressure drop increases while the other dynamic coefficients decrease. Additionally, the stability results show that the novel SET structure exhibits higher stability for positive axial offsets. The novel model and corresponding results can provide a meaningful reference for the study of sealing structure and coupled vibration in the field of fluid machinery.
Revealing the Effect of α’ Decomposition on Microstructure Evolution and Mechanical Properties in Ti80 Alloy
Authors: Xiao Chunhong , Hu Bin , Ge Jinyang , Kong Bin , Luo Deng , Zhang Xiaoyong , Zhou Kechao
Published: May 2024

Three types of solution treatment and aging were designed to reveal the α’ decomposition and its effect on the mechanical properties of near-α Ti-80 alloy, as follows: solution at 970 °C then quenching (ST), ST + aging at 600 °C for 5 h (STA-1), and ST + aging 600 °C for 24 h (STA-2). The results show that the microstructures of the ST samples were mainly composed of equiaxed αp and acicular α’, with a large number of dislocations confirmed by the KAM results. After subsequent aging for 5 h, α’ decomposed into acicular fine αs and nano-β (intergranular β, intragranular β) in the STA-1 specimen, which obstructed dislocation motion during deformation, resulting in the STA-1 specimen exhibiting the most excellent yield strength (1012 MPa) and maintaining sufficient elongation (8.1%) compared with the ST (898 MPa) and STA-2 (871 MPa) samples. By further extending the aging time to 24 h, the size of acicular αs and nano-β gradually increased while the density of dislocations decreased, which resulted in a decrease in strength and an increase in plasticity. Based on this, a microstructures–properties correlation model was proposed. This study provides a new method for strength–plasticity matching of near-α titanium alloys through α’ decomposition to acicular αs+nano-β.
The Influence of Blood and Serum Microenvironment on Spin-Labeled Magnetic Nanoparticles
Authors: Kubiak Tomasz
Published: May 2024

The investigation and clarification of the properties of surface-functionalized superparamagnetic nanoparticles in a biological environment are key challenges prior to their medical applications. In the present work, electron paramagnetic resonance spectroscopy (EPR) combined with the spin labeling technique was utilized to better understand the behavior of nitroxides attached to magnetite nanoparticles dispersed in body fluid. EPR spectra of spin-labeled, silane-coated Fe3O4 nanoparticles in human serum and whole blood were recorded and analyzed for both room- and low-temperature values. In all cases, the obtained EPR signal consisted of a broad line from magnetite cores and a characteristic signal from the attached 4-Amino-2,2,6,6-tetramethylpiperidine-1-oxyl (4-amino-TEMPO). Even for liquid samples, the anisotropic components of magnetic tensors did not fully average out, which was reflected in the differences in the intensity of three narrow hyperfine lines from nitroxide. At 230 K the irregular slow-motion signal from the attached radical was also simulated using the EasySpin toolbox, which allowed to determine the parameters related to magnetic tensors and the dynamics of the spin label. The study showed that the anisotropy of the motion of the spin label 4-amino-TEMPO reflects its interactions with the surrounding medium and the manner of the attachment of the nitroxide to the surface of nanoparticles.
Streamlining Ocean Dynamics Modeling with Fourier Neural Operators: A Multiobjective Hyperparameter and Architecture Optimization Approach
Authors: Sun Yixuan , Sowunmi Ololade , Egele Romain , Narayanan Sri Hari Krishna , Van Roekel Luke , Balaprakash Prasanna
Published: May 2024

Training an effective deep learning model to learn ocean processes involves careful choices of various hyperparameters. We leverage DeepHyper’s advanced search algorithms for multiobjective optimization, streamlining the development of neural networks tailored for ocean modeling. The focus is on optimizing Fourier neural operators (FNOs), a data-driven model capable of simulating complex ocean behaviors. Selecting the correct model and tuning the hyperparameters are challenging tasks, requiring much effort to ensure model accuracy. DeepHyper allows efficient exploration of hyperparameters associated with data preprocessing, FNO architecture-related hyperparameters, and various model training strategies. We aim to obtain an optimal set of hyperparameters leading to the most performant model. Moreover, on top of the commonly used mean squared error for model training, we propose adopting the negative anomaly correlation coefficient as the additional loss term to improve model performance and investigate the potential trade-off between the two terms. The numerical experiments show that the optimal set of hyperparameters enhanced model performance in single timestepping forecasting and greatly exceeded the baseline configuration in the autoregressive rollout for long-horizon forecasting up to 30 days. Utilizing DeepHyper, we demonstrate an approach to enhance the use of FNO in ocean dynamics forecasting, offering a scalable solution with improved precision.
Optimal Control for an Epidemic Model of COVID-19 with Time-Varying Parameters
Authors: Li Yiheng
Published: May 2024

The coronavirus disease 2019 (COVID-19) pandemic disrupted public health and economies worldwide. In this paper, we investigate an optimal control problem to simultaneously minimize the epidemic size and control costs associated with intervention strategies based on official data. Considering people with undetected infections, we establish a control system of COVID-19 with time-varying parameters. To estimate these parameters, a parameter identification scheme is adopted and a mixed algorithm is constructed. Moreover, we present an optimal control problem with two objectives that involve the newly increased number of infected individuals and the control costs. A numerical scheme is conducted, simulating the epidemic data pertaining to Shanghai during the period of 2022, caused by the Omicron variant. Coefficient combinations of the objectives are obtained, and the optimal control measures for different infection peaks are indicated. The numerical results suggest that the identification variables obtained by using the constructed mixed algorithm to solve the parameter identification problem are feasible. Optimal control measures for different epidemic peaks can serve as references for decision-makers.
BIA-ALCL and BIA-SCC: Updates on Clinical Features and Genetic Mutations for Latest Recommendations
Authors: D’Orsi Gennaro , Giacalone Martina , Calicchia Alessio , Gagliano Elettra , Vannucchi Lisa , Vanni Gianluca , Buonomo Oreste Claudio , Cervelli Valerio , Longo Benedetto
Published: May 2024

Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) and Breast Implant-Associated Squamous Cell Carcinoma (BIA-SCC) are emerging neoplastic complications related to breast implants. While BIA-ALCL is often linked to macrotextured implants, current evidence does not suggest an implant-type association for BIA-SCC. Chronic inflammation and genetics have been hypothesized as key pathogenetic players, although for both conditions, the exact mechanisms and specific risks related to breast implants are yet to be established. While the genetic alterations in BIA-SCC are still unknown, JAK-STAT pathway activation has been outlined as a dominant signature of BIA-ALCL. Recent genetic investigation has uncovered various molecular players, including MEK-ERK, PI3K/AKT, CDK4-6, and PDL1. The clinical presentation of BIA-ALCL and BIA-SCC overlaps, including most commonly late seroma and breast swelling, warranting ultrasound and cytological examinations, which are the first recommended steps as part of the diagnostic work-up. While the role of mammography is still limited, MRI and CT-PET are recommended according to the clinical presentation and for disease staging. To date, the mainstay of treatment for BIA-ALCL and BIA-SCC is implant removal with en-bloc capsulectomy. Chemotherapy and radiation therapy have also been used for advanced-stage BIA-ALCL and BIA-SCC. In-depth characterization of the tumor genetics is key for the development of novel therapeutic strategies, especially for advanced stage BIA-ALCL and BIA-SCC, which show a more aggressive course and poor prognosis.
Some Recent Advances in Germanium Recovery from Various Resources
Authors: Alguacil Francisco Jose , Robla Jose Ignacio
Published: May 2024

Though nowadays germanium does not reach the range of popularity of other metals, i.e., rare earth elements, its utility in target industries makes it a strategic metal. Though germanium can be found in a series of raw materials, the principal source for its recovery is from secondary wastes of the zinc industry; also, the recyclability of germanium-bearing waste materials is becoming of interest. In this recovery and due to the size of the target materials, because the diffusion and reaction are to be considered, hydrometallurgy performs a key role in achieving this goal. The present work reviews the most recent applications (2023 and 2024 years) of hydrometallurgical operations on the recovery of germanium from different solid and liquid sources.
Long-Range Influence of Cr on the Stacking Fault Energy of Cr-Containing Concentrated Solid-Solution Alloys
Authors: Xiao Hao , Liu Qingyuan , Zhao Shijun , Xia Songqin , Wang Yugang , Wang Chenxu
Published: May 2024

Single-phase concentrated solid-solution alloys (CSAs) have exhibited excellent mechanical and radiation tolerance properties, making them potential candidate materials for nuclear applications. These excellent properties are closely related to dislocation movements, which depend on the stacking fault energies (SFEs). In CSAs, SFEs show large fluctuations due to variations in the local atomic environments in the vicinity of the stacking faults. In this work, first-principle calculations were performed to investigate the origin of the fluctuations in the SFEs of the widely studied CSA, NiCoCr, which show a very wide distribution from about −200 mJ/m2 to 60 mJ/m2. Compared to the common understanding that only atoms in close proximity to the stacking fault influence the SFEs in pure metals and dilute alloys, charge redistribution can be observed in several nearby planes of the stacking fault in NiCoCr, indicating that atoms several atomic layers away from stacking fault also contribute to the SFEs. Our analysis shows that Cr plays a major role in the large fluctuation in the SFEs of NiCoCr based on both electronic and magnetic responses. The flexible electronic structure of Cr facilitates easier charge transfer with Cr in several nearby atomic planes near the stacking fault, leading to significant changes in the d-electron number, orbital occupation number, and magnetic moments of Cr.
Investigation into the Hot-Forming Limit for 22MnB5 Hot-Forming Steel under a Stamping Process
Authors: He Wenwu , Yang Bin , Zhang Xuezhong , Li Min , Sun Shuli , Wang Bao , Ma Qingxian
Published: May 2024

Hot-forming technology for 22MnB5 hot-forming steel (22MnB5 HF steel) plates has been widely used in the automobile manufacturing industry in recent years. Physical simulation and numerical modeling were carried out in order to determine the forming limit of a 22MnB5 steel plate for the stamping process. The deformation experiments were performed in a temperature range of 600~900 °C and a strain rate range of 0.1~10 s−1. In the uniaxial tensile tests, it was found that at the forming temperature of 600 °C, the condition of dynamic recrystallization was not fully reached, and thus the corresponding tensile strength was much larger than that at other deformation temperatures. In the numerical simulation of bulging experiments, it was found that 22MnB5 steel had good formability when the initial deformation temperature was high and the forming speed was low by using the instability criterion, combining the maximum punch force and strain path transition. The forming limit diagram of 22MnB5 steel at a temperature of 700 °C and tool speed of 25 mm/s was obtained by means of simulation and a hot stamping experiment. The establishment of the forming limit of the 22MnB5 steel plate can provide theoretical and technical guidance for the hot-forming process.
Phase Formation and Magnetic Properties of (Y1−xSmx)Co5 Melt-Spun Ribbons
Authors: Liu Xiang , Yang Siyue , Zheng Xingping , Dai Feilong , Yao Qingrong , Wang Jiang
Published: May 2024

Using X-ray diffraction (XRD) and a vibrating sample magnetometer (VSM), the effects of Sm substitution, wheel speed, and annealing temperature on the phase formation and magnetic properties of (Y1−xSmx)Co5 (x = 0.2, 0.3, 0.4, 0.5) melt-spun ribbons were investigated. The results indicate the following: (1) With the increase in Sm substitution, it was found that (Y1−xSmx)Co5 ribbons are entirely composed of the (Y-Sm)Co5 phase with a CaCu5-type structure. Additionally, the coercivity gradually increases, while the remanence and saturation magnetization gradually decrease. (2) As the wheel speed increases, the (Y1−xSmx)Co5 ribbons exhibit an increasing proportion of (Y-Sm)Co5 phase until reaching a speed of 40 m/s, where they are entirely composed of the (Y-Sm)Co5 phase. Magnetic measurements show that the coercivity (Hcj) and remanence (Br) of (Y0.5Sm0.5)Co5 ribbons increase gradually with increasing wheel speed, while saturation magnetization decreases. The variation in magnetic properties is mainly attributed to the formation of nucleation centers for reversed magnetic domain (2:7 and 2:17 phases); (3) (Y0.5Sm0.5)Co5 ribbons are composed of the (Y-Sm)Co5 phase and a small amount of the Sm2Co7 phase after annealing at 550 °C, 600 °C, and 650 °C. Temperature elevation promotes crystallization of the amorphous phase, resulting in a gradual decrease in coercivity, while the remanence and saturation magnetization exhibit an overall increasing trend. Through continuous optimization of the process, favorable magnetic properties were achieved under the conditions of a 0.5 Sm substitution level, a wheel speed of 40 m/s, and an annealing temperature of 550 °C, with a coercivity of 7.98 kOe, remanence of 444 kA/m, and saturation magnetization of 508 kA/m.