bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis, Tautomeric Structures, and Antitumor Activity of New Perimidines
Authors: Farghaly Thoraya A. , Mahmoud Huda K.
Published: April 2013

New series of perimidine derivatives and fused perimidines were derived from the reaction of ketene aminals 1 and 2 with diazotized anilines or hydrazonoyl chlorides. In addition, 8,10‐disubstituted‐[1,2,4]triazolo[4,3‐a]perimidines (20a–m) were prepared through the reaction of perimidine‐2‐thione (15) with hydrazonoyl chlorides. The structures of the newly synthesized compounds were established on the basis of spectral data and elemental analyses. Some products were investigated for their antitumor activities against the human breast cancer cell line MCF‐7 and the liver carcinoma cell line HEPG‐2, and the results of some derivatives showed promising activity.
Kastenfenster‐Optimierung im historischen Bestand
Authors: Huber Alfons , Korjenic Azra , Bednar Thomas
Published: April 2013

Es ist allgemein bekannt, dass die Energie‐ und CO2‐Einsparung im Gebäudebereich eine zentrale Rolle auf dem Weg zur Erfüllung des Kyoto‐Protokolls und zur Einhaltung der Klimaziele spielt. Während man im Wohn‐ und Bürobereich schon am Plusenergielevel arbeitet, waren bis vor Kurzem alle Optimierungen und Verbesserungen in den Museen nur auf den Haustechnikbereich begrenzt. Der ständig steigende Einsatz von technisch gestützter Klimatisierung hat jedoch im Vergleich mit konventionellen, “passiven“ Klimakonzepten nicht zu der erwarteten signifikanten Verbesserung im historischen Baubestand geführt, dafür aber zu einer enormen Kostensteigerung im Bereich der Haustechnik sowie im laufenden Betrieb. Im Rahmen der hier präsentierten Untersuchungen wurden am Beispiel eines realen Objektes (Neue Burg in Wien) verschiedene Maßnahmen zur Verringerung der Transmissions‐ und Lüftungswärmeverluste sowie zur Reduktion der sommerlichen Wärmeeinträge durch Fenster durchgeführt und deren Auswirkung bewertet. Es hat sich gezeigt, dass durch relativ einfache Maßnahmen das thermische Verhalten von historischen Kastenfenstern um mindestens 25 % verbessert werden kann

Energy performance optimization of historic box‐type windows. It is well known that the energy and CO2 savings in the building sector play a key role in meeting the Kyoto Protocol and climate change targets. While plus energy levels are already being reached in the residential and office building sectors, all optimizations and improvements in museums were limited only to the building services sector until recently. The constantly increasing use of technology‐based air conditioning in comparison with conventional “passive” climate concepts do not result in the expected significant improvements in historical buildings, but an enormous increase in the operating costs of building services. In the study presented here, various measures to reduce transmission and ventilation heat losses, as well as the reduction of summer heat gains through windows were carried out and their effect evaluated on a real object (Neue Burg in Vienna). It has been shown that by relatively simple measures the thermal performance of historic box‐type windows can be improved by at least 25 %.
Impact of cellulase production on environmental and financial metrics for lignocellulosic ethanol
Authors: Hong Yan , Nizami Abdul‐Sattar , Pour Bafrani Mohammad , Saville Bradley A , MacLean Heather L
Published: April 2013

The cost of cellulases remains a key issue in the production of cellulosic ethanol, and the impact of enzymes on greenhouse gas (GHG) emissions of cellulosic ethanol has received little attention. This study evaluates life cycle emissions and cellulase production costs for bioethanol production, considering on‐site and off‐site production options. A complete enzyme production process was simulated using AspenPlus, generating mass and energy balance information required to calculate GHG emissions and financial metrics.

GHG emissions for cellulase production range from 10.2 to 16.0 g CO2 eq g–1 enzyme protein, depending on on‐site or off‐site production and the method of transportation. Enzyme GHG emissions are predicted to be 258 g CO2 eq. L–1 of ethanol for on‐site production, versus 403 g CO2 eq. L–1 for off‐site production, based on a 150 MMLY ethanol plant using 11.5 mg enzyme g–1 substrate and a cellulase fermentation yield of 90%.

Cellulase production costs were estimated for a range of conditions, including ethanol plant size, enzyme dose and protein yield for on‐site production, and enzyme plant size, protein yield and return on investment for off‐site production. On‐site production costs range between $3.80 and $6.75 kg–1 protein, versus $4.00 to $8.80 kg–1 for off‐site production. In both scenarios, the lowest cost corresponds to a 90% protein yield, and a high enzyme demand and production capacity. An enzyme production cost of $4.70 USD kg–1 corresponds to an enzyme cost of 0.46 USD gal–1 ($0.12 L–1) of ethanol in a 150 MMLY plant using 11.5 mg enzyme g–1 substrate. © 2013 Society of Chemical Industry and John Wiley & Sons, Ltd
Systematic study of photoluminescence, lyoluminescence and mechanoluminescence in Ce3+‐ and Eu3+‐activated Li3PO4 phosphors
Authors: Sahu A. K. , Kore Bhushan P , Chowdhary P. S. , Nayar V. , Dhoble S. J.
Published: April 2013

Li3PO4 phosphor was prepared using a modified solid‐state diffusion technique. In this work, photoluminescence, lyoluminescence and mechanoluminescence studies were carried out in a Li3PO4 microcrystalline powder doped with different rare earths. In photoluminescence studies, characteristic emission of Ce and Eu was observed. The lyoluminescence glow curves of Li3PO4 microcrystals show that lyoluminescence intensity initially increases with time and then decreases exponentially. The decay time consists of two components for all masses. The dependence of decay time, especially the longer component, on mass has been investigated. Experiments on γ‐irradiated crystals have proved that the light emission originates from the recombination of released F‐centres with trapped holes (V2‐centres) at the sulfuric acid–solid interface. Incorporation of bivalent alkali in solid lithium phosphate leads to an enhancement of lyoluminescence. A possible explanation for the experimental results has been attempted. The phosphor has a mechanoluminescence single glow peak. Mechanoluminescence intensity under various loading conditions was investigated. It is observed that mechanoluminescence intensity increases with increasing impurity concentration and increasing piston impact velocity. The results may be considered as only being of academic interest in solid‐state materials. Copyright © 2013 John Wiley & Sons, Ltd.
KOH Activation of Thermally Modified Carbon as a Support of Ru Catalysts for Ammonia Synthesis
Authors: Lin Bingyu , Wei Kemei , Ni Jun , Lin Jianxin
Published: April 2013

Carbon supports with a low ratio of micropore volume to total pore volume can be prepared by KOH activation of thermally modified carbon. KOH treatment of carbons in nitrogen led to the creation of basic sites as well as acidic surface groups, whereas KOH treatment in air resulted in more acidic groups. Steam treatment quickly increased the surface area and pore volume, but did not create surface‐reactive groups. The increase in surface areas, micropores, and surface functional groups of carbon supports led to a decrease of the particle sizes, which not only improved the ability of hydrogen to migrate from Ru metal to the remote promoter precursors, but also increased the amount of adsorbed hydrogen and nitrogen. The properties of carbon combined with the size of the Ru particles affected the ammonia‐synthesis activity.
Amine Solutions for Biogas Upgrading: Ideal versus Non‐Ideal Absorption Isotherms
Authors: Privalova E. I. , Mäki‐Arvela P. , Eränen K. , Avetisov A. K. , Mikkola J.‐P. , Murzin D. Yu.
Published: April 2013

Amine solutions were applied in carbon dioxide removal from a model mixture of biogas, carried out in a loop reactor system. In addition, the effect of CO2 absorption acceleration in the presence of piperazine was confirmed and quantified, relating the obtained CO2 loading with the piperazine concentration. Further, the interactions of CO2 and water in aqueous amine solutions were discussed. The obtained acid gas loadings were accurately described taking into account the effect of the dissolved CO2 on the equilibrium constant. A logarithmic absorption isotherm that follows from such considerations and a saturation‐type isotherm were compared. In describing the experimental data, advantages and disadvantages of both approaches are discussed.
Highly Effective Water Oxidation Catalysis with Iridium Complexes through the Use of NaIO4
Authors: Codolà Zoel , M. S. Cardoso João , Royo Beatriz , Costas Miquel , Lloret‐Fillol Julio
Published: April 2013

Exceptional water oxidation (WO) turnover frequencies (TOF=17 000 h−1), and turnover numbers (TONs) close to 400 000, the largest ever reported for a metal‐catalyzed WO reaction, have been found by using [Cp*IrIII(NHC)Cl2] (in which NHC=3‐methyl‐1‐(1‐phenylethyl)‐imidazoline‐2‐ylidene) as the pre‐catalyst and NaIO4 as oxidant in water at 40 °C. The apparent TOF for [Cp*IrIII(NHC)X2] (1 X, in which X stands for I (1 I), Cl (1 Cl), or triflate anion (1 OTf)) and [(Cp*‐NHCMe)IrIIII2] (2) complexes, is kept constant during almost all of the O2 evolution reaction when using NaIO4 as oxidant. The TOF was found to be dependent on the ligand and on the anion (TOF ranging from ≈600 to ≈1100 h−1 at 25 °C). Degradation of the complexes by oxidation of the organic ligands upon reaction with NaIO4 has been investigated. 1H NMR, ESI‐MS, and dynamic light‐scattering measurements (DLS) of the reaction medium indicated that the complex undergoes rapid degradation, even at low equivalents of oxidant, but this process takes place without formation of nanoparticles. Remarkably, three‐month‐old solution samples of oxidized pre‐catalysts remain equally as active as freshly prepared solutions. A UV/Vis feature band at λmax=405 nm is observed in catalytic reaction solutions only when O2 evolves, which may be attributed to a resting state iridium speciation, most probably Ir–oxo species with an oxidation state higher than IV.
Reactions of Pyridyl‐Functionalized, Chelating λ3‐Phosphinines in the Coordination Environment of RhIII and IrIII
Authors: de Krom Iris , Pidko Evgeny A. , Lutz Martin , Müller Christian
Published: April 2013

RhIII and IrIII complexes based on the λ3‐P,N hybrid ligand 2‐(2′‐pyridyl)‐4,6‐diphenylphosphinine (1) react selectively at the PC double bond to chiral coordination compounds of the type [(1H⋅OH)Cp*MCl]Cl (2,3), which can be deprotonated with triethylamine to eliminate HCl. By using different bases, the pKa value of the POH group could be estimated. Whereas [(1H⋅O)Cp*IrCl] (4) is formed quantitatively upon treatment with NEt3, the corresponding rhodium compound [(1H⋅O)Cp*RhCl] (5) undergoes tautomerization upon formation of the λ5σ4‐phosphinine rhodium(III) complex [(1⋅OH)Cp*RhCl] (6) as confirmed by single‐crystal X‐ray diffraction. Blocking the acidic POH functionality in 3 by introducing a POCH3 substituent leads directly to the λ5σ4‐phosphinine iridium(III) complex (8) upon elimination of HCl. These new transformations in the coordination environment of RhIII and IrIII provide an easy and general access to new transition‐metal complexes containing λ5σ4‐phosphinine ligands.
ChemInform Abstract: CuTe: Remarkable Bonding Features as a Consequence of a Charge Density Wave.
Authors: Stolze Karoline , Isaeva Anna , Nitsche Fabian , Burkhardt Ulrich , Lichte Hannes , Wolf Daniel , Doert Thomas
Published: April 2013

CuTe is prepared from the elements by annealing at 470 K for 24 d and characterized by single crystal XRD, HRTEM, and DFT calculations.
ChemInform Abstract: Magnetic Properties and Structural Transitions of Fluorite‐Related Rare Earth Osmates Ln3OsO7 (Ln: Pr, Tb).
Authors: Hinatsu Yukio , Doi Yoshihiro
Published: April 2013

The title compounds are prepared by reaction of Pr6O11 or Tb4O7 and OsO2 (flowing H2 at 900 °C for 1 d and 950 °C for 5 h) and characterized by powder XRD, specific heat, and magnetic susceptibility measurements.
ChemInform Abstract: NiSe2 as an Efficient Electrocatalyst for a Pt‐Free Counter Electrode of Dye‐Sensitized Solar Cells.
Authors: Gong Feng , Xu Xin , Li Zhuoqun , Zhou Gang , Wang Zhong‐Sheng
Published: April 2013

NiSe2 is hydrothermally prepared from combined solutions of Se dissolved in aq.
ChemInform Abstract: Facile Preparation of Nano‐Micro Structure PbSbO2Cl as a Novel Anode Material for Lithium‐Ion Batteries.
Authors: Shu Jie , et al. et al.
Published: April 2013

The title compound is hydrothermally synthesized from aqueous solutions of Pb(NO3)2, SbCl3, and NH4OH (autoclave, 160 °C, 24 h).
ChemInform Abstract: Low Temperature Synthesis of τ‐Zirconium Hydrogenophosphate [τ‐Zr(HPO4)2] and a New Sodic Form Obtained by Ion Exchange.
Authors: Fernandez‐Valverde Suilma M. , Contreras‐Ramirez Aida , Ordonez‐Regil Eduardo , Fernandez‐Garcia M. Eufemia , Perez‐Alvarez Mario
Published: April 2013

The title compound is prepared by solid state reaction of NaH2PO2·H2O, (NH4)2HPO4, and ZrCl4 (1:04:08; flowing N2, 463 K, 2 h).
ChemInform Abstract: Molecular Germanium Selenophosphate Salts: Phase‐Change Properties and Strong Second Harmonic Generation.
Authors: Morris Collin D. , Chung In , Park Sungoh , Harrison Connor M. , Clark Daniel J. , Jang Joon I. , Kanatzidis Mercouri G.
Published: April 2013

The new compounds (Va—f) are characterized by powder and single crystal XRD, SEM, UV/VIS, Raman, and 31P MAS NMR spectroscopy, and nonlinear optical measurements.
ChemInform Abstract: Synthesis, Structural Characterization and Optical Properties of New Compounds: Centrosymmetric Ba2GaMQ5 (M: Sb, Bi; Q: Se, Te), Ba2InSbTe5 and Noncentrosymmetric Ba2InSbSe5.
Authors: Hao Wenyu , Mei Dajiang , Yin Wenlong , Feng Kai , Yao Jiyong , Wu Yicheng
Published: April 2013

The title compounds are prepared from mixtures of BaQ (Q: Se, Te), M12Q3 (M1: Sb, Bi), and M22Q3 (M2: Ga, In) (sealed silica tubes, Ar, 1273 K, 48 h).
ChemInform Abstract: Synthesis, Crystal Structure, and Vibrational Spectroscopic and UV—Visible Studies of Cs2MnP2O7.
Authors: Kaoua Saida , Krimi Saida , Pechev Stanislav , Gravereau Pierre , Chaminade Jean‐Pierre , Couzi Michel , El Jazouli Abdelaziz
Published: April 2013

The title compound is synthesized by precipitation from an aqueous solution of Mn(NO3)2, CsCl, and NH4H2PO4 followed by heating in air (progressive heating 200→700 °C with intermediate grinding).
ChemInform Abstract: Six Novel Transition‐Metal Phosphite Compounds, with Structure Related to Yavapaiite: Crystal Structures and Magnetic and Thermal Properties of AI[MIII(HPO3)2] (A: K, NH4, Rb and M: V, Fe).
Authors: Hamchaoui Farida , Alonzo Veronique , Venegas‐Yazigi Diego , Rebbah Houria , Le Fur Eric
Published: April 2013

Compounds (IIIa—c) and (Va—c) are hydrothermally synthesized (70—87% yield) and characterized by single crystal XRD and magnetic measurements.
ChemInform Abstract: Synthesis of Lithium Cobalt Oxide by Single‐Step Soft Hydrothermal Method.
Authors: Bokinala Kiran Kumar , Pollet M. , Artemenko A. , Miclau M. , Grozescu I.
Published: April 2013

LiCoO2 is hydrothermally synthesized from aqueous solutions of Co(OH)2, LiOH, and H2O2 in the presence of NaOH as additional mineralizer (autoclave, 220 °C, 24—60 h).
ChemInform Abstract: An Efficient Dehydroxymethylation Reaction by a Palladium Catalyst.
Authors: Modak Atanu , Naveen Togati , Maiti Debabrata
Published: April 2013

The title reaction tolerates a variety of substrates, allowing the dehydroxymethylation of aryl‐ and hetaryl compounds (I), as well as the extension of this protocol to aliphatic moieties (III).
ChemInform Abstract: Recyclable Pd‐Incorporated Perovskite‐Titanate Catalysts Synthesized in Molten Salts for the Liquid‐Phase Oxidation of Alcohols with Molecular Oxygen.
Authors: Adilina Indri Badria , Hara Takayoshi , Ichikuni Nobuyuki , Kumada Nobuhiro , Shimazu Shogo
Published: April 2013

A series of Pd‐incorporated titanate catalysts are synthesized by intercalation of Pd(NO3)2 into layered potassium titanate, which proceeds via a cation‐exchange reaction in molten phase.
ChemInform Abstract: Catalytic Enantioselective Allylic Amination of Unactivated Terminal Olefins via an Ene Reaction/[2,3]‐Rearrangement.
Authors: Bao Hongli , Tambar Uttam K.
Published: April 2013

That is the first asymmetric allylic amination of unfunctionalized alkenes using a nitrogen‐containing reagent and a chiral Pd‐catalyst.
ChemInform Abstract: Synthesis, Cyclization, and Evaluation of the Anticancer Activity Against HeLa S‐3 Cells of Ethyl 2‐Acetylamino‐3‐ethynylazulene‐1‐carboxylates.
Authors: Hyoudou Marie , Nakagawa Hajime , Gunji Takahiro , Ito Yoshino , Kawai Yu , Ikeda Reiko , Konakahara Takeo , Abe Noritaka
Published: April 2013

The iodination of azulene derivatives of type (I) or (VI) and some consecutive reactions are studied.
ChemInform Abstract: Efficient and Selective Olefination of Aldehydes with Ethyl Diazoacetate Catalyzed by High‐Valent Tin(IV) Porphyrins.
Authors: Gharaati Shadab , Moghadam Majid , Tangestaninejad Shahram , Mirkhani Valiollah , Mohammadpoor‐Baltork Iraj
Published: April 2013

The title reaction affords exclusively the E‐isomers of the corresponding olefins in short reaction times and in excellent yields under mild conditions.
ChemInform Abstract: Aerobic Oxidation of a Tertiary Aliphatic Amine under Visible‐Light Photocatalysis: Facile Synthesis of Methylene‐Bridged Bis‐1,3‐dicarbonyl Compounds.
Authors: Yoo Woo‐Jin , Tanoue Arata , Kobayashi Shu
Published: April 2013

In some cases addition of Sc(OTf)3 as a co‐catalyst increases the yields of the products.
ChemInform Abstract: Friedel—Crafts Acylation Reactions Using Esters.
Authors: Chavan Subhash P. , Garai Sumanta , Dutta Achintya Kumar , Pal Sourav
Published: April 2013

This method can be used for intermolecular as well as intramolecular Friedel‐Crafts acylations, e.
ChemInform Abstract: Silica Boron Sulfuric Acid Nanoparticles: As an Efficient and Reusable Catalyst for the Large‐Scale Synthesis of α‐Amino Nitriles Using the Strecker Reaction.
Authors: Khalafi‐Nezhad Ali , Foroughi Habib Ollah , Panahi Farhad
Published: April 2013

A highly efficient and green procedure for the synthesis of α‐amino nitriles (IV) (12 examples) via a one‐pot three‐component reaction is given.
ChemInform Abstract: Toluene Derivatives as Simple Coupling Precursors for Cascade Palladium‐Catalyzed Oxidative C—H Bond Acylation of Acetanilides.
Authors: Wu Yinuo , Choy Pui Ying , Mao Fei , Kwong Fuk Yee
Published: April 2013

A cascade cross‐coupling of acetanilides (I), (IV), (VII) and (IX) and toluene derivatives (III), and (V) leading to ortho‐acylacetanilides (III), (VI), (VIII), and (X), respectively, is reported.
ChemInform Abstract: Dimeric ortho‐Palladated Homoveratrylamine as an Efficient Homogeneous Catalyst for Copper‐Free Sonogashira Cross‐Coupling Reaction.
Authors: Hajipour Abdol R. , Rahimi Hannaneh , Rafiee Fatemeh
Published: April 2013

The thermally stable, oxygen and moisture insensitive title catalyst is successfully applied to the Sonogashira cross‐coupling reaction.
ChemInform Abstract: Palladium‐Catalyzed Tandem Carbocyclization—Suzuki Coupling Reactions of Trifluoromethyl‐Containing Building Blocks Leading to 2‐Trifluoromethylindenes.
Authors: Wang Wen‐Ying , Sun Lei‐Lei , Deng Chen‐Liang , Tang Ri‐Yuan , Zhang Xing‐Guo
Published: April 2013

The method allows access to a broad spectrum of indene structures bearing an exocyclic alkylidene part.
ChemInform Abstract: Copper‐Catalyzed Ring‐Opening of Furans as a Concise Route to Polysubstituted Furans under Mild Conditions.
Authors: Yin Biaolin , Yu Huiyue , Li Zhengrong , Zhong Weiqiang , Gu Wenxiang
Published: April 2013

The methodology allows the transformation of various disubstituted furans into tri‐ and tetrasubstituted systems.
ChemInform Abstract: Synthesis and Redox Behavior of Cyanovinyl‐Substituted 2H‐Cyclohepta[b]furan‐2‐ones.
Authors: Shoji Taku , Higashi Junya , Ito Shunji , Oda Mitsunori , Yasunami Masafumi , Morita Noboru
Published: April 2013

Intramolecular charge‐transfer interactions in CH2Cl2 and redox behavior of the novel compounds [(V), (VI), (VIII), and (XI)] are investigated.
ChemInform Abstract: Synthesis and Properties of Azulene‐Substituted Thiophenes, Terthiophenes and Dithienothiophenes.
Authors: Okujima Tetsuo , Toda Akiko , Miyashita Yoko , Nonoshita Ayumi , Yamada Hiroko , Ono Noboru , Uno Hidemitsu
Published: April 2013

Title compounds (III), (V), and (VII) are prepared using Sonogashira—Hagihara conditions and show the small HOMO‐LUMO energy gaps due to their effective π‐conjugation.
ChemInform Abstract: Efficient Synthesis of Chiral 2,2′‐Bipyrrolidines by an anti‐Selective Alkene Diamination.
Authors: Mueller Christian H. , Froehlich Roland , Daniliuc Constantin G. , Hennecke Ulrich
Published: April 2013

The present new intramolecular diamination method is performed either using iodosuccinimide or iodine giving bipyrrolidines and bipiperidines with complete anti‐selectivity.
ChemInform Abstract: Structural Reorganization of Allyl Isothiocyanate into Pyrrole Ring under Superbase: A Straightforward Access to NH‐2‐(Alkylsulfanyl)‐1H‐pyrroles and N‐Alkyl‐2‐(alkylsulfanyl)‐1H‐pyrroles.
Authors: Nedolya Nina A. , Brandsma Lambert , Trofimov Boris A.
Published: April 2013

In the presence of water, the method leads to formation of pyrroles (III).
ChemInform Abstract: One‐Pot Synthesis of Bisindolylmethanes from Benzyl Alcohols and Indoles Using Catalytic Iodine and Molecular Oxygen under Visible Light Irradiation.
Authors: Nobuta Tomoya , Fujiya Akitoshi , Tada Norihiro , Miura Tsuyoshi , Itoh Akichika
Published: April 2013

Catalytic molecular iodine is used for both the aerobic photooxidation of the alcohols to aldehydes and the condensation of the latter with indoles.
ChemInform Abstract: Rhodium‐Catalyzed One‐Pot Intermolecular [2 + 2 + 2] Trimerization/Asymmetric Intramolecular [4 + 2] Cycloaddition of Two Aryl Ethynyl Ethers and 5‐Alkynals.
Authors: Miyauchi Yuta , Noguchi Keiichi , Tanaka Ken
Published: April 2013

This reaction yields substituted annulated 1,4‐cyclohexadienes with excellent enantioselectivities.
ChemInform Abstract: Assembly of Spirooxindole Derivatives via Organocatalytic Iminium‐Enamine Cascade Reactions.
Authors: Albertshofer Klaus , Anderson Kimberly E. , Barbas Carlos F. III
Published: April 2013

Title compounds are obtained in high yields and enantioselectivities in a single step.
ChemInform Abstract: Enantioselective Construction of Multifunctionalized Spirocyclohexaneoxindoles Through Organocatalytic Michael—Aldol Cyclization of Isatin Derived Alkenes with Linear Dialdehydes.
Authors: Huang Xiao‐Fei , Liu Zhao‐Min , Geng Zhi‐Cong , Zhang Shao‐Yun , Wang Yong , Wang Xing‐Wang
Published: April 2013

An asymmetric methodology for the construction of formyl, hydroxyl, and ester functionalized spirocyclohexaneoxindoles in good yields with moderate diastereoselectivity and excellent enantioselectivity is reported.
ChemInform Abstract: Metal‐Free Catalyzed Oxidative Trimerization of Indoles by Using TEMPO in Air: A Biomimetic Approach to 2‐(1H‐Indol‐3‐yl)‐2,3′‐biindolin‐3‐ones.
Authors: Qin Wen‐Bing , Chang Qiong , Bao Yun‐Hong , Wang Ning , Chen Zheng‐Wang , Liu Liang‐Xian
Published: April 2013

A novel, operationally simple, and practical biomimetic synthetic method for the trimerization of indoles using TEMPO in air as oxidant is presented.
ChemInform Abstract: Synthesis of 2‐Arylindole Derivatives and Evaluation as Nitric Oxide Synthase and NFϰB Inhibitors.
Authors: Yu Xufen , Park Eun‐Jung , Kondratyuk Tamara P. , Pezzuto John M. , Sun Dianqing
Published: April 2013

A library of 2‐phenylindole derivatives is synthesized by one‐pot palladium‐catalyzed Sonogashira‐type alkynylation reactions and base‐assisted cycloaddition reactions.
ChemInform Abstract: Asymmetric Diels—Alder Reaction of 2‐Methyl‐3‐indolylmethanols via in situ Generation of o‐Quinodimethanes.
Authors: Xiao You‐Cai , Zhou Qing‐Qing , Dong Lin , Liu Tian‐Yu , Chen Ying‐Chun
Published: April 2013

The present new title reaction catalyzed by a secondary chiral amine is applicable to a wide range of aryl‐substituted indole derivatives (I) and α,β‐unsaturated aldehydes.
ChemInform Abstract: Synthesis and Antimicrobial Evaluation of Novel Pyrazolones and Pyrazolone Nucleosides.
Authors: Hassan Abdalla E. A. , Moustafa Ahmed H. , Tolbah Mervat M. , Zohdy Hussein F. , Haikal Abdelfattah Z.
Published: April 2013

Novel dihydropyrazolones and their N2 alkyl, ribofuranosyl, and glucopyranosyl derivatives are prepared by potassium carbonate‐mediated alkylation or by glycosylation under Vorbrueggen conditions.
ChemInform Abstract: Zwitterionic‐Type Molten Salt‐Catalyzed Multicomponent Reactions: One‐Pot Synthesis of Substituted Imidazoles under Solvent‐Free Conditions.
Authors: Bagdi Matiur Rahman Avik Kr. , Kundu Dhiman , Majee Adinath , Hajra Alakananda
Published: April 2013

For the first time, an ionic liquid catalyzed synthesis of 1,2,5‐tri‐ and 1,2,4,5‐tetrasubstituted imidazoles is reported.
ChemInform Abstract: Conventional and Microwave‐Assisted Synthesis of Benzimidazole Derivatives and Their in vitro Inhibition of Human Cyclooxygenase.
Authors: Secci Daniela , Bolasco Adriana , D'Ascenzio Melissa , della Sala Flavio , Yanez Matilde , Carradori Simone
Published: April 2013

Using a novel microwave‐assisted oxidative cyclization procedure, a large series of benzimidazole derivatives is prepared and evaluated for their ability to inhibit human cyclooxygenases.
ChemInform Abstract: A Facile Solvent‐Free Synthesis of Chiral Oxazolidinone Derivatives Catalyzed by MgI2 Etherate: An Approach to Enantiopure Synthesis of Linezolid.
Authors: Zhang Xingxian , Zhao Chengfeng , Gu Yue
Published: April 2013

Stereoselective cycloaddition of aryl isocyanates to chiral oxiranes proceeds smoothly under solvent‐free conditions using freshly prepared magnesium iodide etherate as catalyst.
ChemInform Abstract: One‐Pot Microwave‐Assisted Synthesis of Novel Substituted N‐Dichloroacetyl‐4,5‐dimethyl‐1,3‐oxazolidines.
Authors: Fu Ying , Yang Lei , Ye Fei , Gao Shuang
Published: April 2013

Synthesis and biological evaluation of title compounds (IV) as potential plant protecting additives to the herbicide acetochlor are described.
ChemInform Abstract: Copper‐Catalyzed Oxidative [2 + 2 + 1] Cycloaddition: Regioselective Synthesis of 1,3‐Oxazoles from Internal Alkynes and Nitriles.
Authors: Li Xianwei , Huang Liangbin , Chen Huoji , Wu Wanqing , Huang Huawen , Jiang Huanfeng
Published: April 2013

This is an efficient and highly regioselective oxazole synthesis under aerobic conditions.
ChemInform Abstract: Click Synthesis of 5‐Substituted 1H‐Tetrazoles from Aldehydes, Hydroxylamine, and [bmim]N3 via One‐Pot, Three‐Component Reaction.
Authors: Heravi Majid M. , Fazeli Azadeh , Oskooie Hossein A. , Beheshtiha Yahya S. , Valizadeh Hassan
Published: April 2013

Replacement of nitrile substrates by aromatic aldehydes and the use of ionic liquid [bmim]N3 instead of NaN3 allow an easy and efficient approach to the desired tetrazoles.
ChemInform Abstract: Asymmetric Iodolactonization Utilizing Chiral Squaramides.
Authors: Tungen Joern E. , Nolsoee Jens M. J. , Hansen Trond V.
Published: April 2013

This method is better in terms of enantioselectivity than previously published approaches.
ChemInform Abstract: Synthesis and anti‐Avian Influenza Virus (H5N1) Evaluation of Some Novel Nicotinonitriles and Their N‐Acyclic Nucleosides.
Authors: Rashad Aymn E. , Shamroukh Ahmed H. , El‐Hashash Maher A. , El‐Farargy Ahmed F. , Yousif Nabil M. , Salama Mowafia A. , Mostafa Ahmed , El‐Shahat Mahmoud
Published: April 2013

Pyridine derivative (IV) is easily synthesized by a four‐component modified Hantzsch reaction and used as key intermediate for the preparation of a series of novel fused pyridine derivatives and some acyclic nucleoside derivatives [cf.
ChemInform Abstract: Synthesis of Phenanthridinones via Palladium‐Catalyzed C(sp2)—H Aminocarbonylation of Unprotected o‐Arylanilines.
Authors: Liang Dongdong , Hu Ziwei , Peng Jiangling , Huang Jinbo , Zhu Qiang
Published: April 2013

Optimal reaction conditions are found for the conversion of o‐arylanilines (I) and (IV) into phenanthridinones by aminocarbonylation.
ChemInform Abstract: Synthesis and Insecticidal Activities of Chlorothiazolyl Analogues of Nitromethylene Neonicotinoids with Tetrahydropyridine Fixed cis‐Configuration.
Authors: Shao Xusheng , Huang Xinglong , Shi Qian , Li Zhong , Tao Liming , Song Gonghua
Published: April 2013

A series of the title thiazole derivatives (V) (22 examples) is synthesized and evaluated for their insecticidal activities.
ChemInform Abstract: An Efficient Method for the Synthesis of 3‐Aryl‐4,7‐phenanthroline Derivatives Catalyzed by Iodine.
Authors: Yin Ming‐Yue , Zhang Mei‐Mei , Wang Wei , Li Yu‐Ling , Wang Xiang‐Shan
Published: April 2013

3‐Aryl‐4,7‐phenanthrolines (IV) are easily accessible via iodine‐catalyzed three‐component reaction of quinoline‐6‐amine, butyl vinyl ether and an aromatic aldehyde.
ChemInform Abstract: Iron(II)‐Catalyzed Denitration Reaction: Synthesis of 3‐Methyl‐2‐arylimidazo[1,2‐a]pyridine Derivatives from Aminopyridines and 2‐Methylnitroolefins.
Authors: Yan Hao , Yang Sizhou , Gao Xiai , Zhou Kang , Ma Chao , Yan Rulong , Huang Guosheng
Published: April 2013

The simple protocol allows the synthesis of various pharmaceutically interesting imidazopyridine structures via Michael addition of 2‐aminopyridines to nitrostyrenes followed by cyclization and elimination of nitrous acid.
ChemInform Abstract: Baylis—Hillman Acetates in Organic Synthesis: Convenient One‐Pot Synthesis of α‐Carboline Framework — A Concise Synthesis of Neocryptolepine.
Authors: Basavaiah Deevi , Reddy Daggula Mallikarjuna
Published: April 2013

A facile, one‐pot methodology for the synthesis of pyridoindole derivatives from corresponding Baylis—Hillman acetates is reported.
ChemInform Abstract: Study of Cyclization of o‐(‐Alkynyl)‐ and o‐(1,3‐Butadiynyl)aryltriazenes under the Action of Acids.
Authors: Danilkina N. A. , Gorbunova E. G. , Sorokoumov V. N. , Balova I. A.
Published: April 2013

Under the action of acids, title compounds (I) and (V) undergo cyclization to form cinnolines (II) and (VI), respectively.
ChemInform Abstract: Microwave‐Assisted Synthesis, Molecular Docking and Antitubercular Activity of 1,2,3,4‐Tetrahydropyrimidine‐5‐carbonitrile Derivatives (IV)
Authors: Mohan Sahoo Biswa , Kumar B. V. V. Ravi , Dinda S. C. , Naik D. , Seenivasan S. Prabu , Kumar Vanaja , Rana Dharmarajsinh N. , Brahmkshatriya Pathik S.
Published: April 2013

16 examples
ChemInform Abstract: Chlorotrimethylsilane‐Promoted Condensation of Ketones and Aminoazoles.
Authors: Ryabukhin Sergey V. , Naumchik Vasiliy S. , Grygorenko Oleksandr O. , Tolmachev Andrey A.
Published: April 2013

Tms‐Cl‐promoted reaction of aminoazoles with ketones (II) provides dihydroazolopyrimidine derivatives such as (III) and (V) as single regioisomers.
ChemInform Abstract: Synthesis and Molecular Structure of 2,3,4,5‐Tetrahydro‐1H‐3‐benzazepine Derivatives and Dimethyl 4‐Cyano‐2,3,6,7‐tetrahydro‐1H‐3‐benzazonine‐5,6‐dicarboxylate.
Authors: Soldatenkov A. T. , Soldatova S. A. , Mamyrbekova‐Bekro J. A. , Gimranova G. S. , Malkova A. V. , Polyanskii K. B. , Kolyadina N. M. , Khrustalev V. N.
Published: April 2013

Treatment of quaternary tetrahydroisoquinolinium salts (I) with NaH results in the formation of tetrahydrobenzazepine derivatives via a Stevens rearrangement.
ChemInform Abstract: Condensed Diazepines. Synthesis of 1‐R‐3,4‐Dihydro‐5H‐benzothieno[2,3‐d][1,2]diazepin‐4‐ones
Authors: Tolkunov V. S. , Eres'ko A. B. , Mazepa A. V. , Palamarchuk G. V. , Shishkin O. V. , Tolkunov S. V.
Published: April 2013

via reactions of benzothienopyrones or 2‐aroylbenzothiophene‐3‐acetic acids with hydrazine
ChemInform Abstract: Multicomponent Synthesis of Diverse 1,4‐Benzodiazepine Scaffolds.
Authors: Huang Yijun , Khoury Kareem , Chanas Tyler , Doemling Alexander
Published: April 2013

Entitled 1,4‐benzodiazepines are of particular interest in drug design.
ChemInform Abstract: Efficient Synthesis of Imidazole‐Fused Benzodiazepines Using Palladium‐Catalyzed Intramolecular C—N Bond Formation Reaction.
Authors: Mitra Sudipta , Darira Heena , Chattopadhyay Partha
Published: April 2013

The intramolecular Buchwald—Hartwig cycloamination reaction of precursors (V) is the key‐step in the three‐step synthetic route to the title benzodiazepines (VI).
ChemInform Abstract: Iron(III) Catalyzed Direct Synthesis of cis‐2,7‐Disubstituted Oxepanes. The Shortest Total Synthesis of (+)‐Isolaurepan.
Authors: Purino Martin A. , Ramirez Miguel A. , Daranas Antonio H. , Martin Victor S. , Padron Juan I.
Published: April 2013

Title compounds are synthesized by iron(III)‐catalyzed Prins cyclization of bis‐homoallylic alcohols with aldehydes in the presence of trimethylsilyl chloride to avoid the formation of tetrahydrofurans.
ChemInform Abstract: Reaction of Grignard Reagents with Diisopropylaminoborane. Synthesis of Alkyl, Aryl, Heteroaryl and Allyl Boronic Acids from Organo(diisopropyl)aminoborane by a Simple Hydrolysis.
Authors: Bailey Christopher L. , Murphy Chris L. , Clary Jacob W. , Eagon Scott , Gould Naomi , Singaram Bakthan
Published: April 2013

Boronic acids (III) are synthesized by Grignard reaction of aminoborane (I), whereas boronic acids (V) are synthesized by reaction of (I) with in situ formed Grignard reagents (Barbier conditions).
ChemInform Abstract: Bis‐E‐chloromethylidene Derivatives of 4‐Thio‐ and 4‐Selenomorpholinamines
Authors: Martynov A. V. , Makhaeva N. A. , Larina L. I. , Amosova S. V.
Published: April 2013

synthesis and spectroscopic characterization
ChemInform Abstract: Total Synthesis of (+)‐Heteroplexisolide E.
Authors: Kutsumura Noriki , Kiriseko Akito , Saito Takao
Published: April 2013

The first total synthesis of (+)‐heteroplexisolide E (I) is presented.
ChemInform Abstract: Toward the Synthesis of Modified Carbohydrates by Conjugate Addition of Propane‐1,3‐dithiol to α,β‐Unsaturated Ketones.
Authors: Valdersnes Stig , Apeland Ingrid , Flemmen Guri , Sydnes Leiv K.
Published: April 2013

MeONa‐mediated addition of dithiol (II) to alkynes (I) is accompanied by an intramolecular cyclization to afford spiro compounds (III), which can be regarded as partly modified furanose derivatives.
ChemInform Abstract: Chemical Selforganization of Composite Catalysts During Catalytic Reactions
Authors: Imbihl Ronald
Published: April 2013

Review: 35 refs.
ChemInform Abstract: Scalable Synthesis and Device Integration of Self‐Registered One‐Dimensional Zinc Oxide Nanostructures and Related Materials
Authors: Nikoobakht Babak , Wang Xudong , Herzing Andrew , Shi Jian
Published: April 2013

Review: 161 refs.
ChemInform Abstract: Magnetically Retrievable Catalysts for Organic Synthesis
Authors: Baig R. B. Nasir , Varma Rajender S.
Published: April 2013

Review: 109 refs.
ChemInform Abstract: Adventures in Bridgehead Substitution Chemistry: Synthesis of Polycyclic Polyprenylated Acylphloroglucinols (PPAPs)
Authors: Simpkins Nigel S.
Published: April 2013

Review: 41 refs.
ChemInform Abstract: Development of Carbazole Dyes for Efficient Molecular Photovoltaics
Authors: Koumura Nagatoshi , Hara Kohjiro
Published: April 2013

Review: 56 refs.
ChemInform Abstract: Stepping Toward Ideality
Authors: Crow James Mitchell
Published: April 2013

Review: review on current trends in optimization of organic synthesis; 7 refs.
ChemInform Abstract: Pyrazol‐5‐ones: Tautomerism, Synthesis and Reactions
Authors: Metwally M. A. , Bondock S. A. , El‐Desouky S. I. , Abdou M. M.
Published: April 2013

Review: 244 refs.
ChemInform Abstract: Domino Reactions in the Enantioselective Synthesis of Bioactive Natural Products
Authors: Tietze Lutz F. , Stewart Scott G. , Duefert Alexander
Published: April 2013

Review: 248 refs.
ChemInform Abstract: Rearrangements in Natural Product Synthesis
Authors: Marco‐Contelles Jose , Soriano Elena
Published: April 2013

Review: 202 refs.
ChemInform Abstract: C‐H Functionalization: A New Strategy for the Synthesis of Biologically Active Natural Products
Authors: Rousseaux Sophie , Liegault Benoit , Fagnou Keith
Published: April 2013

Review: 213 refs.
ChemInform Abstract: Asymmetric Phase‐Transfer Catalysis
Authors: Shirakawa Seiji , Moteki Shin A. , Maruoka Keiji
Published: April 2013

Review: 128 refs.
ChemInform Abstract: Heavy Fermions in a High Magnetic Field
Authors: Aoki Dai , Knafo William , Sheikin Ilya
Published: April 2013

Review: 176 refs.
ChemInform Abstract: Transient Free Radicals in Viscous Solvents
Authors: Khudyakov Igor V.
Published: April 2013

Review: 72 refs.
ChemInform Abstract: Chromium Pollution and Bioremediation: An Overview
Authors: Das Nilanjana , Mathew Lazar
Published: April 2013

Review: 164 refs.
ChemInform Abstract: Galactic Chemical Evolution and the Oxygen Isotopic Composition of the Solar System
Authors: Nittler Larry R. , Gaidos Eric
Published: April 2013

Review: 74 refs.
ChemInform Abstract: Conformational Analysis of Furanoside‐Containing Mono‐ and Oligosaccharides
Authors: Taha Hashem A. , Richards Michele R. , Lowary Todd L.
Published: April 2013

Review: 564 refs.
Retinorecipient areas in the diurnal murine rodent Arvicanthis niloticus: A disproportionally large superior colliculus
Authors: Gaillard Frédéric , Karten Harvey J. , Sauvé Yves
Published: April 2013

The Nile grass rat (Arvicanthis niloticus) has a high proportion of cone photoreceptors (∼30–40%) compared with that in the common laboratory mouse and rat (∼1–3%) and may prove a preferable murine model with which to study cone‐driven information processing in retina and primary visual centers. However, other than regions involved in circadian control, little is known about the retinorecipient structures in this rodent. We undertook a detailed analysis of the retinal projections as revealed after intravitreal injection of the anterograde tracer cholera toxin subunit B. Retinal efferents were evaluated in 45 subcortical structures. Contralateral projections were always dominant. Major contralateral inputs consisted of the suprachiasmatic nucleus, dorsolateral geniculate nucleus (dLGN), intergeniculate leaflet, ventral geniculate nucleus (magnocellular part), lateroposterior thalamic nucleus, all six pretectal nuclei, superficial layers of the superior colliculus (SC), and the main nuclei of the accessory optic system. Terminals from the contralateral eye were also localized in an unnamed field rostromedial to the dLGN as well as in the subgeniculate thalamic nucleus. Ipsilateral inputs were found mainly in the suprachiasmatic nucleus, dLGN, intergeniculate leaflet, internal sector of the magnocellular part of the ventral geniculate nucleus, olivary pretectal nucleus, and SC optic layer. Retinal afferents were not detected in the basal forebrain or the dorsal raphe nucleus. Morphometric measurements revealed that the superficial layers of the SC are disproportionately enlarged relative to other retinorecipient regions and brain size compared with rats and mice. We suggest that this reflects the selective projection of cone‐driven retinal ganglion cells to the SC. J. Comp. Neurol. 521:1699–1726, 2013. © 2012 Wiley Periodicals, Inc.
Molecule‐Induced Peroxide Homolysis
Authors: Turrà Natascia , Neuenschwander Ulrich , Hermans Ive
Published: April 2013

The homolytic cleavage of peroxide bonds, leading to the formation of free radicals, plays an important role in the (spontaneous) oxidation of a wide variety of hydrocarbons in the presence of oxygen. Such aerobic oxidations can be desired (e.g. for industrially applied autoxidations) or undesired (e.g. food deterioration). In this contribution we provide experimental and computational evidence for a molecule‐induced homolytic dissociation mechanism between alkyl peroxide and compounds featuring weakly bonded H atoms such as (di)unsaturated hydrocarbons.
From Coordination Polyhedra to Molecular Environment and Back – Interplay between Coordinate and Hydrogen Bonds in Two Polymorphs of a Cobalt Complex
Authors: Ananyev Ivan V. , Nefedov Sergey E. , Lyssenko Konstantin A.
Published: April 2013

Two crystalline modifications of a cobalt(II) benzoate complex containing substituted pyrazole ligands are investigated. The polymorphs are characterized by different intermolecular bonding as well as by different metal‐atom environments. A thorough analysis of the chemical bonding patterns by means of Bader's “Atoms in Molecules” theory reveals the significant role of N–H···O hydrogen bonds in charge transfer within the molecule and in stabilization of unfavorable [4+1] cobalt polyhedra. Specifically, an estimation of the interaction energies according to an Espinosa correlation scheme shows the significant contribution of H bonds to the stabilization energy of the molecular conformations.
Electrochemical and Catalytic Studies of a Manganese(III)Complex with a Tetradentate Schiff‐Base Ligand Encapsulated in NaY Zeolite
Authors: Kuźniarska‐Biernacka Iwona , Rodrigues Otilia , Carvalho Maria Alice , Parpot Pier , Biernacki Krzysztof , Magalhães Alexandre Lopes , Fonseca Antonio Mauricio , Neves Isabel Correia
Published: April 2013

The manganese(III) complex with a Schiff‐base salen‐type ligand (1,5‐bis{[(1E)‐(2‐hydroxyphenyl)methylene]amino}‐1H‐imidazole‐4‐carbonitrile) has been encapsulated in the nanopores of a Y zeolite by using two different methodologies, the flexible ligand and in situ complex preparation methods. Cyclic voltammetry studies revealed that the neat complex undergoes reversible oxidation in dmf, which has been attributed to the MnII/III redox couple, whereas the two heterogeneous catalysts show different electrochemical behaviour in aqueous medium. The encapsulated and non‐encapsulated homogeneous MnIIIsalen complexes were screened as catalysts for olefin oxidation by using tBuOOH as the oxygen source in different solvents. Under the optimized conditions, the catalysts exhibited moderate activity. Both heterogeneous catalysts catalysed the oxidation of cyclohexene with tBuOOH, primarily to give the allylic oxidation products. These catalysts were found to be reusable after the catalytic cycle, but with some loss of activity. A DFT study confirmed the distortion of the complex in the zeolite cage, the main difference being observed for the bonded chloride.
Metabolomic discrimination between patients with stable angina, non‐ST elevation myocardial infarction, and acute myocardial infarct
Authors: Calderón‐Santiago Mónica , Priego‐Capote Feliciano , Galache‐Osuna José G. , Luque de Castro María D.
Published: April 2013

The ischemic cascade starts when atherosclerotic plaques decrease the supply of oxygen and substrates to cells and finalizes with myocardial infarction. These states have been here studied at metabolite level by optimization of a metabolomics profiling approach based on high‐accuracy MS. For this purpose, serum samples from patients diagnosed with coronary artery disease and affected by stable angina or myocardial infarction (acute myocardial infarction or non‐ST elevation myocardial infarction) were analyzed by LC‐QTOF/MS after deproteinization to compare the profile of serum metabolites. The data set, composed by tentative molecular features detected in MS analyses, was filtered with statistical algorithms to remove entities resulting in redundant information. Tentative molecules were identified finding mainly lipids as statistically significant metabolites in the discrimination study due to their change in concentration. Lipids such as bile acid derivatives, phospholipids, and triglycerides were identified as relevant compounds for discrimination of individuals who suffered acute or non‐ST elevation myocardial infarction from those suffering stable angina. The results achieved by this research could support the capability of metabolomics to go inside the study of artery diseases, and in addition to other omics disciplines could help to detect the occurrence of these disorders at initial stages or even to prognosticate their appearance.
Differences and similarities between LC‐MS derived serum fingerprints of patients with B‐cell malignancies
Authors: Piszcz Jaroslaw , Lemancewicz Dorota , Dudzik Danuta , Ciborowski Michal
Published: April 2013

Multiple myeloma (MM) and chronic lymphocytic leukaemia (CLL) are closely related B‐cell non‐Hodgkin's lymphomas. MM, a plasma cell malignancy, is the second most common haematopoietic cancer in Western countries, with the median survival time of 3–4 years. CLL, a lymphocyte B malignancy, is the most common leukaemia in Western countries. About 25–30% of all CLL patients do not survive the period of 5 years following diagnosis. Both malignancies are complicated, not fully understood and incurable with the current standard treatment. Biologically, MM and CLL may be preceded by associated precursor conditions, that is, monoclonal gammopathy of undetermined significance for MM and its cellular counterpart and monoclonal B‐cell lymphocytosis for CLL. Similarities and differences in the biology of these malignancies prompted us to evaluate their metabolomics in stages requiring chemotherapy. Fingerprinting of serum metabolites by the use of LC‐MS has never been applied in studies on MM and CLL patients. Obtained results revealed metabolites common for both malignancies (e.g. fatty acids, acylcarnitines, sphingolipids, phospholipids, phenylalanylphenylalanine and isoprene) as well as those which render them different (e.g. lysophosphatidylcholines, monoacylglycerols, aminocaproic acid, phenylacetylglutamine).
Serum lipid profiling of patients with chronic hepatitis B, cirrhosis, and hepatocellular carcinoma by ultra fast LC/IT‐TOF MS
Authors: Chen Shili , Yin Peiyuan , Zhao Xinjie , Xing Wenbin , Hu Chunxiu , Zhou Lina , Xu Guowang
Published: April 2013

In this study, an ultra fast LC/IT‐TOF MS (UFLC/IT‐TOF MS)‐based serum lipidomics method was employed to characterize the serum lipid profile of patients with chronic hepatitis B, cirrhosis, and hepatocellular carcinoma (HCC). After data collection and processing, 96 lipids including lysophosphatidylcholines, phosphatidylcholines, sphingomyelins, triacylglycerides, and cholesterol esters were identified and used for subsequent data analysis. Partial least squares‐discriminant analysis revealed that patients with liver diseases had distinctly different serum lipid profile from that of healthy controls; while cirrhosis and HCC patients had a similar serum lipid profile, but different from that of hepatitis patients. The ANOVA analysis found 75 of the 96 identified lipids to be abnormally regulated, among which most of these lipids were downregulated in cirrhosis and HCC patients compared with those of healthy controls and hepatitis patients, while hepatitis patients induced several lipids downregulated and others upregulated compared with those of healthy controls, indicating the aberrant lipid metabolism in patients with liver diseases. This work demonstrated the utility of UFLC/IT‐TOF MS‐based serum lipidomics as a powerful tool to investigate the lipid metabolism of liver diseases.
Rapid separation of fatty acids using a poly(vinyl alcohol) coated capillary in nonaqueous capillary electrophoresis with contactless conductivity detection
Authors: Buglione Lucia , See Hong Heng , Hauser Peter C.
Published: April 2013

The determination of fatty acids by nonaqueous CZE with capacitively coupled contactless conductivity detection was investigated. A new deoxycholate‐based BGE, which had previously been found to give significantly improved baseline stability in the determination of lipophilic organic ammonium ions, was found to be similarly beneficial for the determination of the anions. The use of a PVA‐coated capillary was required for suppression of the EOF and to obtain well reproducible results. The complete separation of 12 fatty acids could be achieved with 10 mM DOC in methanol within 6 min under optimized conditions. The PVA‐coated capillary demonstrated outstanding stability over 300 runs with no sign of depletion of the PVA layer. Method validation showed a good linearity range from 0.75 to 25 μM with correlation coefficients between 0.9949 and 0.9979. The LOD was determined as 0.5 μM for all fatty acids. The developed approach was successfully demonstrated for the separation of free fatty acids in commercial and home‐made edible oil.