bluuebunny/crossref_metadata_2025 huggingface dataset:
Cisplatin-Based Neoadjuvant Chemotherapy for Elderly Patients with Muscle-Invasive Bladder Cancer: Is It Feasible?
Authors:   Medical oncology department, Saint-Louis Hospital, AP-HP.Nord - Université de Paris, Paris, France, Dumont Clément , Lefèvre Madeleine ,   Oncogeriatry unit, AP-HP.Nord - Université de Paris, Paris, France, Aussedat Quiterie ,   Medical oncology department, Saint-Louis Hospital, AP-HP.Nord - Université de Paris, Paris, France, Reignier Pierre-Louis ,   Urology department,Saint-Louis Hospital, AP-HP.Nord - Université de Paris, Paris, France, Masson-Lecomte Alexandra ,   Urology department, Saint-Louis Hospital, AP-HP.Nord - Université de Paris, Paris, France, Xylinas Evanguelos ,   Urology department, Bichat Hospital, AP-HP.Nord - Université de Paris, Paris, France, Gauthier Hélène ,   Medical oncology department, Saint-Louis Hospital, AP-HP.Nord - Université de Paris, Paris, France, Fossey-Diaz Virginie ,   Oncogeriatry unit, AP-HP.Nord - Université de Paris, Paris, France, Arégui Amélie ,   Oncogeriatry unit, AP-HP.Nord - Université de Paris, Paris, France, Culine Stéphane ,   Medical oncology department, Saint-Louis Hospital, AP-HP.Nord - Université de Paris, Paris, France,   Oncogeriatry unit, AP-HP.Nord - Université de Paris, Paris, France
Published: November 2021

Cisplatin-based neoadjuvant chemotherapy (C-NAC) has been the standard of care in localized muscle-invasive bladder cancer (MIBC). However, the feasibility and benefit of C-NAC in elderly patients remain uncertain since this population has always been underrepresented in pivotal trials and is often barred from chemotherapy in routine practice because of their perceived frailty. Therefore, in order to evaluate the effectiveness of C-NAC in elderly patients with MIBS, we retrospectively reviewed the medical files of patients (cT2-4, N0-3, and M0) treated at our institution and aged 75 or older at the time of the first chemotherapy cycle. From May 2012 to March 2020, 51 patients aged 75 to 90 received C-NAC. Among them, 38 patients received methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC) and 13 patients received gemcitabine and cisplatin (GC). In this study, the primary endpoint was the feasibility of C-NAC, evaluated as the percentage of patients who underwent at least four chemotherapy cycles. Overall feasibility of a complete four-cycle chemotherapy course was 75% (dose-dense MVAC [dd-MVAC]: 76%; GC: 69%). Incidence of grade 3-4 adverse events was 57%, mostly driven by hematological toxicity from dd-MVAC, and the incidence of febrile neutropenia was 6%. These results indicate the feasibility of C-NAC in elderly patients without any contraindication to cisplatin. A coordinated multidisciplinary approach, including a geriatric oncologist, may help to identify patients at increased risk for chemotherapy-induced toxicity, especially in patients aged 85 or older.
Ethical Issues of Digital Twins for Personalized Health Care Service: Preliminary Mapping Study
Authors: Huang Pei-hua , Kim Ki-hun , Schermer Maartje
Published: November 2021

Background

The concept of digital twins has great potential for transforming the existing health care system by making it more personalized. As a convergence of health care, artificial intelligence, and information and communication technologies, personalized health care services that are developed under the concept of digital twins raise a myriad of ethical issues. Although some of the ethical issues are known to researchers working on digital health and personalized medicine, currently, there is no comprehensive review that maps the major ethical risks of digital twins for personalized health care services.

Objective

This study aims to fill the research gap by identifying the major ethical risks of digital twins for personalized health care services. We first propose a working definition for digital twins for personalized health care services to facilitate future discussions on the ethical issues related to these emerging digital health services. We then develop a process-oriented ethical map to identify the major ethical risks in each of the different data processing phases.

Methods

We resorted to the literature on eHealth, personalized medicine, precision medicine, and information engineering to identify potential issues and developed a process-oriented ethical map to structure the inquiry in a more systematic way. The ethical map allows us to see how each of the major ethical concerns emerges during the process of transforming raw data into valuable information. Developers of a digital twin for personalized health care service may use this map to identify ethical risks during the development stage in a more systematic way and can proactively address them.

Results

This paper provides a working definition of digital twins for personalized health care services by identifying 3 features that distinguish the new application from other eHealth services. On the basis of the working definition, this paper further layouts 10 major operational problems and the corresponding ethical risks.

Conclusions

It is challenging to address all the major ethical risks that a digital twin for a personalized health care service might encounter proactively without a conceptual map at hand. The process-oriented ethical map we propose here can assist the developers of digital twins for personalized health care services in analyzing ethical risks in a more systematic manner.
Patients’ Expectations and Experiences With a Mental Health–Focused Supportive Text Messaging Program: Mixed Methods Evaluation
Authors: Shalaby Reham , Vuong Wesley , Eboreime Ejemai , Surood Shireen , Greenshaw Andrew J , Agyapong Vincent Israel Opoku
Published: November 2021

Background

Web-based services are an economical and easily scalable means of support that uses existing technology. Text4Support is a supportive, complementary text messaging service that supports people with different mental health conditions after they are discharged from inpatient psychiatric care.

Objective

In this study, we aim to assess user satisfaction with the Text4Support service to gain a better understanding of subscribers’ experiences.

Methods

This was a mixed methods study using secondary data from a pilot observational controlled trial. The trial included 181 patients discharged from acute psychiatric care and distributed into 4 randomized groups. Out of the 4 study groups in the initial study, 2 groups who received supportive text messages (89/181, 49.2% of patients), either alone or alongside a peer support worker, were included. Thematic and descriptive analyses were also performed. Differences in feedback based on sex at birth and primary diagnosis were determined using univariate analysis. The study was registered with ClinicalTrials.gov (trial registration number: NCT03404882).

Results

Out of 89 participants, 36 (40%) completed the follow-up survey. The principal findings were that Text4Support was well perceived with a high satisfaction rate either regarding the feedback of the messages or their perceived impact. Meanwhile, there was no statistically significant difference between satisfactory items based on the subscriber’s sex at birth or primary diagnosis. The patients’ initial expectations were either neutral or positive in relation to the expected nature or the impact of the text messages received on their mental well-being. In addition, the subscribers were satisfied with the frequency of the messages, which were received once daily for 6 consecutive months. The participants recommended more personalized messages or mutual interaction with health care personnel.

Conclusions

Text4Support was generally well perceived by patients after hospital discharge, regardless of their sex at birth or mental health diagnosis. Further personalization and interactive platforms were recommended by participants that may need to be considered when designing similar future services.
Impact of Virtual Reality-Based Therapies on Cognition and Mental Health of Stroke Patients: Systematic Review and Meta-analysis (Preprint)
Authors: Zhang Qi , Fu Yu , Lu Yanhui , Zhang Yating , Huang Qifang , Yang Yajie , Zhang Ke , Li Mingzi
Published: November 2021

BACKGROUND

Stroke remains one of the major chronic illnesses worldwide that health care organizations will need to address for the next several decades. Individuals poststroke are subject to levels of cognitive impairment and mental health problems. Virtual reality (VR)-based therapies are new technologies used for cognitive rehabilitation and the management of psychological outcomes.

OBJECTIVE

This study performed a meta-analysis to evaluate the effects of VR-based therapies on cognitive function and mental health in patients with stroke.

METHODS

A comprehensive database search was performed using PubMed, MEDLINE (Ovid), Embase, Cochrane Library, and APA PsycINFO databases for randomized controlled trials (RCTs) that studied the effects of VR on patients with stroke. We included trials published up to April 15, 2021, that fulfilled our inclusion and exclusion criteria. The literature was screened, data were extracted, and the methodological quality of the included trials was assessed. Meta-analysis was performed using RevMan 5.3 software.

RESULTS

A total of 894 patients from 23 RCTs were included in our meta-analysis. Compared to traditional rehabilitation therapies, the executive function (standard mean difference [SMD]=0.88, 95% confidence interval [CI]=0.06-1.70, P=.03), memory (SMD=1.44, 95% CI=0.21-2.68, P=.02), and visuospatial function (SMD=0.78, 95% CI=0.23-1.33, P=.006) significantly improved among patients after VR intervention. However, there were no significant differences observed in global cognitive function, attention, verbal fluency, depression, and the quality of life (QoL).

CONCLUSIONS

The findings of our meta-analysis showed that VR-based therapies are efficacious in improving executive function, memory, and visuospatial function in patients with stroke. For global cognitive function, attention, verbal fluency, depression, and the QoL, further research is required.

CLINICALTRIAL

PROSPERO International Prospective Register of Systematic Reviews CRD42021252788; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=252788
Technology-Aided Spatial Cues, Instructions, and Preferred Stimulation for Supporting People With Intellectual and Visual Disabilities in Their Occupational Engagement and Mobility: Usability Study (Preprint)
Authors: Lancioni Giulio E , Singh Nirbhay N , O'Reilly Mark F , Sigafoos Jeff , Alberti Gloria , Chiariello Valeria , Campodonico Francesca , Desideri Lorenzo
Published: November 2021

BACKGROUND

Persons with severe or profound intellectual disability and visual impairment tend to be passive and sedentary, and technology-aided intervention may be required to improve their condition without excessive demands on staff time.

OBJECTIVE

This study aims to extend the assessment of technology-aided interventions for supporting functional occupational engagement and mobility in 7 people with intellectual disability and visual impairment and to use a technology system that is simpler and less expensive than those previously used.

METHODS

The technology system involved a Samsung Galaxy A10, 4 Philips Hue indoor motion sensors, and 4 mini speakers. Within each session, the participants were to collect 18 objects (ie, one at a time) from 3 different areas (stations) located within a large room, bring each of the objects to a central desk, and put away each of those objects there. For each object, the participants received verbal (spatial) cues for guiding them to the area where the object was to be collected, a verbal instruction (ie, request) to take an object, verbal (spatial) cues for guiding them to the central desk, a verbal instruction to put away the object collected, and praise and preferred stimulation.

RESULTS

During baseline, the frequency of responses completed correctly (objects collected and put away independently) was 0 or near 0. During the intervention phase (ie, with the support of the technology setup), the frequency increased for all participants, reaching a mean of almost 18 (out of 18 response opportunities) for 6 participants and about 13 for the remaining participant. The mean session duration ranged from 12 to 30 minutes.

CONCLUSIONS

A program, such as the one used in this study, can be useful in promoting occupational engagement and mobility in persons with intellectual disability and visual impairment.

CLINICALTRIAL
Missing Cooperation in the Eastern Mediterranean
Authors: Doll Luca
Published: November 2021

Resource discoveries and an emerging maritime arms race in the Eastern Mediterranean have created incentives for an overarching security cooperation framework However, collaboration in the mentioned sectors remains absent and the former regional coalitions have been reconfigured. This article investigates why a lack of cooperation in the Eastern Mediterranean persists. In answering this question, Securitzation Theory and Regional Security Complex Theory (RSCT) serve as a theoretical foundation. Building on the latter theories, seeing the Eastern Mediterranean as a regional security complex leads to the contention that if two or more units of this system securitize each other’s activities within the said complex, this will lead to negative ramifications on regional collaboration. The chosen case is the reciprocal securitization of Turkey and Greece in 2020. Finally, the case study reveals blind spots in RSCT and introduces a new concept to cope with these: the buffer subcomplex.
ORAL DELIVERY OF SILVER NANOPARTICLES – A REVIEW
Authors: JOSHI VEDAMURTHY , SULTHANA FIRDOS , RAMADAS DINESHA
Published: November 2021

Silver nanoparticles (NP) offer many applications in the science and technology. Oral delivery of such tiny particles results in enhanced drug absorption, reduction in dose, and minimize adverse effects. This review focuses on the mainly on the effects in the gastrointestinal tract along with its in vitro and in vivo studies carried on the silver NP. In this review, we compiled some of the extensive research in the field of silver NP, highlighting some of the most recent trends in the area. Search was carried in English language using Science direct, PubMed, and Google scholar search engines. The effects of silver NP on gastrointestinal tract such as absorption, distribution, metabolism, and elimination were compiled in this review. In addition, selected in vitro and in vivo studies related to the same are discussed. The accumulation of silver NP leading to Arginia condition also emphasized in the study. Silver NP and herbal silver NP in oral delivery can be exploited for the further safer and effective treatment.
AWAKENING CHARACTERISTICS AND RECOVERY OF COGNITIVE FUNCTION IN PATIENTS UNDERGOING SHORT SURGICAL PROCEDURES: COMPARISON BETWEEN DESFLURANE AND PROPOFOL
Authors: BASHA FERNAZ , S PARTHASARATHY , CHARLES S ANTONY JOHN , M RAVISHANKAR , KUMAR VR HEMANTH
Published: November 2021

Objectives: Early awakening and recovery of the cognitive function improves post-operative outcome and early discharge of the patients. Desflurane and Propofol offer rapid emergence from anesthesia. We compared the awakening and recovery of cognitive function between these two agents.
Methods: A total of 50 patients aged 30–60 years belonging to ASA 1 and 2 were studied. In both the groups baseline, Mini Mental State Examination (MMSE) score was recorded and were induced with Target controlled infusion (TCI) of Propofol to achieve plasma site concentration (Cp) of 6 mcg/ml. Group P continued with TCI Propofol Cp 3 mcg ml-1 and in group D, TCI was stopped and started Desflurane 6% end tidal concentration followed by Desflurane 3%. Hemodynamic variables were noted and after stopping the agent, time to eye open, squeeze hands, removal of laryngeal mask airway, state name, and modified Aldrete score were noted. MMSE score was recorded 1, 6, and 24 h postoperatively.
Results: Awakening time was significantly shorter in duration in Desflurane group compared to Propofol. The mean time to eye open in the Propofol group was 10.41±2:31 min and Desflurane group was 06.21±01.42 min (***p=0.000). There was an increase in the mean MMSE score postoperatively at 6 h and 24 h interval when compared to the baseline within the groups. However, there was no difference in recovery of cognitive function between the two groups.
Conclusion: The use of inhalational agent Desflurane provided shorter awakening time than intravenous Propofol in short surgical procedures but the recovery of cognitive function was comparable. There were no significant side effects.
ПРИМЕНЕНИЕ ТЕХНОЛОГИЙ РАДИОФОТОНИКИ ПРИ СОЗДАНИИ ЛОКАТОРОВ КОСМИЧЕСКОГО БАЗИРОВАНИЯ С СИНТЕЗИРОВАННОЙ АПЕРТУРОЙ
Authors: Лось В.О.
Published: November 2021

Предложены технические решения по созданию локатора космического базирования на основе технологий радиофотоники. Проведен анализ технических решений с учетом требований к радарам с синтезированной апертурой.
Using HDFS to Load, Search, and Retrieve Data from Local Data Nodes
Authors: Goyal Shubh
Published: November 2021

Abstract: By utilizing the Hadoop environment, data may be loaded and searched from local data nodes. Because the dataset's capacity may be vast, loading and finding data using a query is often more difficult. We suggest a method for dealing with data in local nodes that does not overlap with data acquired by script. The query's major purpose is to store information in a distributed environment and look for it quickly. In this section, we define the script to eliminate duplicate data redundancy when searching and loading data in a dynamic manner. In addition, the Hadoop file system is available in a distributed environment. Keywords: HDFS; Hadoop distributed file system; replica; local; distributed; capacity; SQL; redundancy
El rol del supervisor de campo clínico en Enfermería: perspectiva estudiantil
Authors: Otárola Millar Yerty , Illesca Pretty Mónica , Hernández Díaz Alejandro Antonio
Published: November 2021

Objetivo: Conocer la opinión de estudiantes de la carrera de Enfermería de la Universidad Autónoma de Chile, respecto del rol del supervisor clínico. Metodología: Investigación cualitativa, descriptiva, interpretativa a través de un estudio intrínseco de caso. Muestra intencionada, de casos por criterios y por conveniencia, conformada por 24 estudiantes de quinto año, previa firma del consentimiento informado, año 2015. Recolección de datos mediante tres grupos focales; para el análisis de ellos se utilizó reducción progresiva y agrupación en categorías descriptivas. Se utilizaron los criterios de rigor de Guba, triangulando por investigadores. Aspectos éticos resguardados por el Comité Ético de Universidad de La Frontera. Resultados: En el Nivel 1 emergieron 257 unidades de significado, agrupadas en: “Factores obstaculizadores del supervisor clínico”, “Características del supervisor clínico”, “Factores facilitadores del supervisor clínico” y “significado del supervisor clínico”. En el Nivel 2 surgen tres núcleos temáticos, finalizando en el Nivel 3 con dos dominios cualitativos: “Factores asociados al supervisor clínico que inciden en el proceso enseñanza-aprendizaje” y “Perfil y atributos del supervisor clínico”. Conclusiones: Para los educandos es importante la formación docente y disciplinar de quien realiza la supervisión clínica, destacando las habilidades interpersonales para ejercer el rol.
Expressing volition, imposition and latency through causatives
Authors:   Ivane Javakhishvili Tbilisi State University, Tbilisi, Georgia, Orkodashvili Mariam
Published: November 2021

The present study analyzes the different ways in which causative structures in these languages express the ideas of causation, volition vs imposition, and temporal sequencing of actions. The examples have been gathered from media discourse (written and spoken examples of news reports, articles or discussions from electronic media), and informal conversations with the native speakers of the languages during interviews and discussions. The forms of expressing the concepts of desire, wish, will on the one hand, and the forms of expressing imposition, request, incentive, order or involuntary action, on the other, differ across languages from purely syntactic structures to morphological, or lexical-semantic means. Latent causation is yet further interesting issue raised in the paper.
Functions and Frequency of Using Code-switching in CLIL Lesson (Case Study, teaching Math (CLIL) in the private school, Tbilisi)
Authors:   Ivane Javakhishvili Tbilisi State University, Tbilisi, Georgia, Buskivadze Khatuna
Published: November 2021

The aim of the present study is to investigate the sociolinguistic functions and frequency of Teacher’s Code Switching (CS) in the content and language integrated (CLIL) Lesson. Furthermore, our purpose is to reveal students’ and teacher’s attitudes towards teacher’s code-switching in CLIL lesson. After a brief review of the literature concerning CLIL and the issue of code-switching the case study of teaching Math (Educational discourse) in one of the private schools in Tbilisi will be outlined as data, gathered by means of anonymous questionnaires, which were administered among students in the abovementioned Math classes. Moreover, the qualitative research aims to single out the number of teacher’s CS examples and analyze the interview with math’s teacher. The results show that there are 36 cases of teacher using L1 (Georgian) in 10 lessons (9 hours). Math’s teacher’s CS behavior mostly serves (1) the conversational function of interjection; (2) the classroom functions of introducing unfamiliar materials and topics, explaining difficult concepts, maintaining classroom discipline and the structure of the lesson; The teacher and 13 students have negative attitudes towards using only Georgian in teaching Math’s. The higher level of English the students have the more negative is attitude towards using Georgian in the classroom. Although all the students were Georgian, their competence in English is almost as high as in their mother tongue, therefore they consider English as an inseparable part of their identities.
Recursos e Práticas de enfrentamento de pessoas em situação de rua: uma revisão sistemática
Authors: Esmeraldo Filho Carlos Eduardo , Morais Ximenes Verônica
Published: November 2021

O objetivo desse estudo é analisar a produção científica acerca das estratégias de enfrentamento das pessoas em situação de rua em estudos publicados de 2008 a 2019. Foi feita uma revisão sistemática de literatura, a partir das bases Scielo e BIREME, com inclusão de artigos publicados em inglês, português e espanhol. Usou-se o descritor homeless, selecionando-se 36 artigos para análise. Os resultados foram organizados a partir das categorias: “recursos para o enfrentamento” e “práticas de enfrentamento”. Em relação aos recursos, os artigos destacam o desenvolvimento de habilidades dessas pessoas e as redes de apoio social disponíveis. Quanto às práticas de enfrentamento, apresentam-se as ações concretas, tanto para se adaptar como para promover transformações. Destaca-se a necessidade de investigar as pessoas em situação de rua no sentido de fortalecer estratégias de enfrentamento.
Políticas públicas, práticas de encarceramento e políticas do corpo
Authors: Nardi Henrique Caetano , Guareschi Neuza Maria de Fátima , Galeano Giovana Barbieri
Published: November 2021

Editorial.
Gender-Specific Outcomes after Percutaneous Left Atrial Appendage Closure - A Nationwide Readmission Database Analysis
Authors: Patel Neel , Ranka Sagar , Hajra Adrija , Bandyopadhyay Dhrubajyoti , Amgai Birendra , Chakraborty Sandipan , Khalid Mazin , Goyal Amandeep , Dalia Tarun , Reddy Madhu , Shani Jacob
Published: November 2021

Background: Thromboembolism-associated stroke is the most feared
complication of Atrial fibrillation (AF). Percutaneous left atrial
appendage closure (pLAAC) is indicated for stroke prevention in patients
with AF who can’t tolerate long-term anticoagulation. We aim to study
gender differences in peri-procedural and readmissions outcomes in pLAAC
patients. Methods: Using the national readmission database from January
2016 to December 2018, AF patients undergoing the pLAAC procedure were
identified. We used multivariate logistic regression analyses and
time-to-event Cox regression analyses to conduct the study. Propensity
matching with the Greedy method was done for the accuracy of results.
Result: 28,819 patients were included in our study. Among them 11,946
(41.5%) were women and 16,873 (58.6%) were men. The mean age of
overall population was 76.1 ± 8.5 years, with women ~ 1
year older than men. The overall rate of complications was higher in
women (8.6% vs 6.6%, P<0.001), primarily driven by
bleeding-related complications i.e., Major bleed (OR: 1.32 95% CI:
1.03-1.69, p=0.029), blood transfusion (OR: 1.45, 95% CI: 1.06-1.97,
p=0.019) and cardiac tamponade (OR: 1.80, 95% CI: 1.13-2.89, p=0.014).
Women had two times higher peri-procedural ischemic stroke. There was no
difference in peri-procedural mortality. Women remained at 20% and 13%
higher risk for readmission at 30 days and 6 months of discharge.
Conclusion: Women had higher peri-procedural complications and were at
higher risk of readmissions at 30 days and six months. However, there
was no difference in mortality during the index hospitalization. Further
studies are necessary to determine causality.
Two-step Ulm-type method for solving nonlinear operator equations
Authors: Ma Wei , Hua Liuqing
Published: November 2021

In this paper, we present a two-step Ulm-type method to solve systems of
nonlinear equations without computing Jacobian matrices and solving Jacobian
equations. we prove that the two-step Ulm-type method converges locally to
the solution with R-convergence rate 3. Numerical implementations
demonstrate the effectiveness of the new method.
A unified common fixed point theorem for a family of mappings
Authors: Dalakoti Vijay , Bisht Ravindra , Pant R.P. , Joshi Mahesh
Published: November 2021

The main objective of the paper is to prove some unified common fixed point
theorems for a family of mappings under a minimal set of sufficient
conditions. Our results subsume and improve a host of common fixed point
theorems for contractive type mappings available in the literature of the
metric fixed point theory. Simultaneously, we provide some new answers in a
general framework to the problem posed by Rhoades (Contemp Math 72, 233-245,
1988) regarding the existence of a contractive definition which is strong
enough to generate a fixed point, but which does not force the mapping to be
continuous at the fixed point. Concrete examples are also given to
illustrate the applicability of our proved results.
Holomorphic mappings into the complex projective space with moving hypersurfaces
Authors: Yang Liu
Published: November 2021

Motivated by Eremenko?s accomplisshment of a Picard-type theorem [Period Math
Hung. 38 (1999), pp.39-42.], we study the normality of families of
holomorphic mappings of several complex variables into PN(C) for moving
hypersurfaces located in general position. Our results generalize and
complete previous results in this area, especially the works of Dufresnoy,
Tu-Li, Tu-Cao, Yang-Fang-Pang and the recent work of Ye-Shi-Pang.
Restricted AccessA Randomized Crossover Trial Comparing Glucose Control During Moderate-Intensity, High-Intensity, and Resistance Exercise With Hybrid Closed-Loop Insulin Delivery While Profiling Potential Additional Signals in Adults With Type 1 Diabetes
Authors: Paldus Barbora , Morrison Dale , Zaharieva Dessi P. , Lee Melissa H. , Jones Hannah , Obeyesekere Varuni , Lu Jean , Vogrin Sara , Gerche André La , McAuley Sybil A. , MacIsaac Richard J , Jenkins Alicia J. , Ward Glenn M. , Colman Peter , Smart Carmel , Seckold Rowen , King Bruce , Riddell Michael C. , O’Neal David N.
Published: November 2021

Objective: To
compare glucose control with hybrid closed loop (HCL) when challenged by
moderate-intensity exercise (MIE), high-intensity intermittent exercise (HIE)
and resistance exercise (RE) while profiling counter-regulatory hormones,
lactate, ketones, and kinetic data in adults with type 1 diabetes.

Methods: Open-label
multisite randomized crossover trial. Adults with type 1 diabetes undertook
40 min of HIE, MIE, and RE in random order while using HCL (Medtronic 670G) with
a temporary target set 2 hours prior to and during exercise and 15g carbohydrates
if pre-exercise glucose was <126mg/dL, to prevent hypoglycemia. Primary
outcome was median (IQR) continuous glucose monitoring (CGM) time-in-range
(TIR, 70-180 mg/dL) for 14 hours post-exercise commencement. Accelerometer data and venous glucose, ketones,
lactate, and counter-regulatory hormones were measured for 280 min
post-exercise commencement.

Results: Median
TIR was 81%
[67, 93]%, 91% [80, 94]%, and 80% [73, 89]% for 0-14 hours post-exercise commencement for HIE, MIE and RE,
respectively (n=30), with no difference between exercise types (MIE v HIE;
p=0.11, MIE v RE p=0.11, HIE v RE p=0.90). Time-below-range was 0% for all
exercise bouts. For HIE and RE compared with MIE, there
were greater increases respectively in noradrenaline (p=0.01, p=0.004),
cortisol (p<0.001, p=0.001), lactate (p£0.001, p£0.001)
and heart rate (p=0.007, p=0.015). During HIE compared with MIE, there were
greater increases in growth hormone (p=0.024).

Conclusions: Under
controlled conditions, HCL provided satisfactory glucose control with no
difference between exercise type. Lactate, counter-regulatory hormones, and
kinetic data differentiate type and intensity of exercise, and their
measurement may help inform insulin needs during exercise. However, their
potential utility as modulators of insulin dosing will be limited by the
pharmacokinetics of subcutaneous insulin delivery.
KARAKTERISITK SIFAT FISIK TANAH PADA LAHAN PRODUKSI RENDAH DAN TINGGI DI PT GREAT GIANT PINEAPPLE
Authors: Holilullah Holilullah , Afandi Afandi , Novpriansyah Hery
Published: November 2021

Sifat fisik tanah merupakan sifat tanah yang berpengaruh terhadap pertumbuhan dan poduksi tanaman karena akan menentukan penetrasi akar di dalam tanah, kemampuan tanah menahan air, drainase, aerasi tanah dan ketersediaan unsur hara tanah. Penelitian ini bertujuan untuk mempelajari dan mengetahui karakteristik sifat fisik yang terdapat pada lahan yang berproduksi rendah dan tinggi. Penelitian dilaksanakan dari bulan Juni sampai September tahun 2013 diPT Great Giant Pineapple (GGP), Lampung Tengah. Penelitian dilakukan dengan menggunakan metode survey dengan menentukan titik sebanyak 6 titik secara diagonal pada lokasi 26 B. Pengambilan sampel tanah dilakukan dengan 2 cara, yaitu mengambil sampel tanah secara langsung dengan menggunakan cangkul dan pengambilan menggunakan ring sampel dengan kedalaman 0 – 20, 20 – 40 dan 40 – 60 cm serta pada setiap titik dilakukan pembuatan minipit yang bertujuan untuk mengamati profil dan warna tanah. Hasil penelitian menunjukkan bahwa Karakteristik sifat fisik pada lahan produksi rendah memiliki pori drainase sangat rendah sampai dengan sedang, warna tanah coklat kekuningan, tekstur tanah liat berpasir, kekuatan tanah 77,35 psi – 178,89 psi dan kerapatan isi idealpertumbuhan akar dari kedalaman 0 – 40 cm yaitu sebesar 1,36 g cm -3 pada kedalaman 0 – 20 cm dan 1,41 g cm -3 pada kedalaman 20 – 40 cm. Sedangkan Karakteristik sifat fisik pada lahan produksi tinggi memiliki pori drainase sangat rendah sampai dengan sedang, warna tanah orange, tekstur tanah liat berpasir, kekuatan tanah 96,69 psi – 125,70 psi dan kerapatan isi ideal pertumbuhan akar dari kedalaman 0 – 60 cm yaitu sebesar 1,29 g cm -3 pada kedalaman 0 – 20 cm, 1,38 g cm -3 pada kedalaman 20 – 40 cm dan 1,45 g cm -3 pada kedalaman 40 – 60 cm.
PENGARUH SISTEM OLAH TANAH DAN APLIKASI HERBISIDA TERHADAP POPULASI DAN BIOMASSA CACING TANAH PADA PERTANAMAN UBI KAYU (Manihot utilissima)
Authors: Sari Yetti Komala , Niswati Ainin , Arif M.A. Syamsul , Yusnaini Sri
Published: November 2021

Ubi kayu merupakan tanaman pangan yang banyak dibudidayakan di Provinsi Lampung. Mayoritas petani ubi kayu menerapkan sistem olah tanah intensif beserta aplikasi herbisida kimia dengan anggapan lebih efisien waktu, tenaga, dan biaya namun melupakan dampak negatifnya terhadap kesuburan lahan Penelitian ini bertujuan untuk mengetahui pengaruh sistem olah tanah dan aplikasi herbisida terhadap populasi dan biomassa cacing tanah pada pertanaman ubi kayu (Manihot utilissima) diLahan Lapangan Terpadu Fakultas Pertanian, Universitas Lampung. Percobaan dirancang menggunakan RAK dengan dua faktor yaitu sistem olah tanah (T) dan aplikasi herbisida (H). Sistem olah tanah terdiri dari olah tanah intensif (T 1 ) dan olah tanah minimum (T 2 ), sedangkan aplikasi herbisida terdiri dari tanpa aplikasi herbisida (H 0 ) dan aplikasi herbisida (H 1 ). Herbisida yang digunakan yaitu herbisida berbahan aktif isopropilamina glifosat + isopropilamina 2,4 D dengan dosis yang digunakan yaitu 160 ml/1 tangki (1 tangki=16 liter air). Data yang diperoleh diuji dengan analisis ragam dan dilanjutkan dengan uji BNT.Hasil penelitian menunjukkan bahwa sistem olah tanah tidak berpengaruh terhadap populasi dan biomassa cacing tanah, namun perlakuan herbisida berpengaruh terhadap populasi cacing tanah pada pengamatan 0 BST (sebelum tanam), dan uji BNT menunjukkan bahwa populasi cacing tanah lebih tinggi pada lahan yang tidak diaplikasikan herbisida. Populasi danbiomassa cacing tanah ditemukan lebih tinggi pada lapisan tanah 0 – 10 cm dan identifikasi cacing tanah di laboratorium menunjukkan bahwa cacing tanah yang ditemukan yaitu dari famili Megascolecidae genus Pheretima. Uji korelasi menunjukkan bahwa kadar air tanah berpengaruh terhadap populasi maupun biomassa cacing tanah.
PENGARUH TINGKAT KONSENTRASI FRAKSI EKSTRAK DAUN MENGKUDU DAN MIMBA TERHADAP PERTUMBUHAN DAN SPORULASI Colletotrichum capsici
Authors: Anggreini Septy , Efri Efri , Nurdin Muhammad
Published: November 2021

Salah satu penyakit utama yang menyerang tanaman cabai adalah penyakit antraknosa yang disebabkan oleh Colletotrichum capsici. Penelitian ini bertujuan untuk mengetahui tingkat keefektifan fraksi ekstrak daun mengkudu dan fraksi ekstrak daun mimba serta mempelajari pengaruh tingkat konsentrasi fraksi ekstrak daun mengkudu dan fraksi ekstrak daun mimba dalam menekan pertumbuhan dan sporulasi jamur C. capsici secara in vitro. Penelitian ini dilakukan di Laboratorium Ilmu Penyakit Tumbuhan Fakultas Pertanian Universitas Lampung pada bulan April 2015 sampai Juli 2015. Alat yang digunakan antara lain alat fraksinasi sederhana, mikropipet, haemocytometer, dan Laminar air flow. Bahan yang digunakan antara lain daun mengkudu, daun mimba, biakan C. capsici, dan media Potato Sucrose Agar (PSA). Penelitian ini menggunakan rancangan acak lengkap (RAL) tersarang dengan dua faktor dan data dianalisis ragam kemudian dilanjutkan dengan perbandingan polinomial ortogonal pada taraf 1%. Hasil penelitian menunjukkan bahwa fraksi ekstrak daun mengkudu dan fraksi ekstrak daun mimba memiliki keefektifan yang tidak berbeda dalam menghambat pertumbuhan dan sporulasi C. capsici secara in vitro. Tingkat konsentrasikedua jenis fraksi ekstrak tanaman tersebut berbeda dalam menghambat pertumbuhan dan sporulasi C. capsici. Semakin tinggi tingkat konsentrasi fraksi ekstrak tanaman uji tidak selalu diikuti dengan meningkatnya daya hambat terhadap pertumbuhan diameter koloni C. capsici, tetapi semakin tinggi tingkat konsentrasi fraksi ekstrak tanaman tersebut semakin efektif untuk menghambat sporulasi C. capsici.
Dissemination and Training of Identification and Development of Sport Talent for Physical Education Teachers and Sports Trainers in the Province of West Sumatra
Authors: Atradinal Atradinal , Syahputra Risky , Oktarifaldi Oktarifaldi , Mardela Romi , Putri Lucy Pratama , Oktavianus Irfan , Mariati Sari , Johor Zainul , Bakhtiar Syahrial
Published: November 2021

In many sporting events that have been held both nationally and internationally, Indonesia is still ranked below. Observations that have been made on PJOK teachers and trainers have found that they have not been able to identify and develop sports talent optimally by applying science. Research that has been done proves that an athlete is not only born but is also created through an appropriate talent identification program. There are at least two instruments that can be used to identify children's talents, namely I do and I Like. This application I like is online and saves and processes the data of children that we input and then will provide an output in the form of a dominant sport that is suitable for children. While I do in the form of tests of the ability of children with predetermined instruments. This service activity aims to: a) have skills in identifying and developing talent, b) understand and be skilled in using I do and I like instruments as part of talent identification, c) able to implement the management of talent identification instruments in their respective places. The method used uses the principle that every innovation received by PJOK teachers and trainers through PIE (Preparation, Implementation and Evaluation). This means that the delivery of innovations to Partners is taken through the stages of explanation, discussion, practice and evaluation stages are carried out with assistance in the learning and training process
Wisata Germanggis dan Potensinya Sebagai Prasarana Aktivitas Jasmani Siswa Sekolah Dasar
Authors: Kusuma Indra Jati , Kusnandar Kusnandar , Nurcahyo Panuwun Joko , Festiawan Rifqi
Published: November 2021

Penelitian ini bertujuan untuk: 1). Mengetahui potensi Germanggis untuk dijadikan prasarana aktivitas jasmani, 2) Mengetahui faktor penghambat dalam pengembangan Germanggis sebagai prasarana aktivitas jasmani, 3) Mengetahui faktor pendukung Germanggis, untuk dijadikan prasarana aktivitas jasmani. Penelitian ini merupakan penelitian deskriptif kualitatif. Teknik pengumpulan data diperoleh melalui observasi, focus group discusion, wawancara dan dokumentasi. Informan ditentukan dengan teknik purposive sampling untuk pengelola dan snowball sampling untuk guru dan siswa. Digunakan trianggulasi data untuk keabsahannya, dan analisa interaktif model Miles dan Huberman untuk menganalisa datanya. Hasilnya: 1) Potensi dari Germanggis yaitu memiliki sumber mata air yang cukup, berdiri diatas lahan seluas 1,5 hektar, dan masih ada 3,5 Hektar lagi untuk dikembangkan, udaranya masih sejuk, pandangan saat sunrise dan sunset bagus, 2) Faktor Penghambatnya; jalannya menanjak, belum dilalui jalur bus, 3) Faktor Pendukungnya: harga tiket masuk terjangkau, tersedianya fasilitas ibadah dan warung makan, banyak terdapat spot foto menarik, terdapat area camping, dan area outbond masih dalam penataan. Kesimpulan: Objek Wisata Germanggis sudah mulai digunakan oleh Guru Penjasorkes untuk pembelajaran aktivitas jasmani berbasis outdoor activity karena terdapat fasilitas yang mendukung yaitu camping ground, outbound, fasilitas ibadah dan warung makan, spot foto. Germanggis dapat digunakan sebagai prasarana pembelajaran aktivitas jasmani berbasis outdoor activity karena respon guru dan siswa sangat baik setelah melakukan pembelajaran aktivitas jasmani berbasis outdoor activity.
Jejak Religi Pada Makam Gerald Alfred Cup di Perkebunan Kina Cinyiruan Masa Kolonial
Authors: Nuralia Lia
Published: November 2021

Cinyiruan Plantation of Chinchona has become part of the garden (afdeeling) of the Kertamanah Plantation. Traces of the Cinyiruan Plantation culture can still be traced, one of which is the tomb of Gerald Alfred Cup. What and how the existence of the tomb is the main problem in this paper. The research method used is desk research with a historical approach. The results obtained are that the tomb of Gerald Alfred Cup shows traces of Christian religion in the Cinyiruan Plantation of Chinchona, and the tolerant religious life on the plantations during the colonial period. Traces of religion based on the shape of the tomb marker and European (Dutch) name on tomb inscription. Gerald Alfred Cup or Tuan Keup is a Dutch, plant expert and the last Cinyiruan Plantation of Chinchona of Administrator. The tolerant religious life in the plantations is indicated by the traces of the tomb as an indication of the existence of Christianity and the presence of mosques in the settlements of the workers. The plantation workers are the original indigenous people of the local village who are mostly Muslim.
Abiraterone acetate – 10 clinically relevant facts
Authors: Żołnierek Jakub
Published: November 2021

Prostate cancer is one of the most frequently diagnosed cancers in men. Number of newly diagnosed cases is increasing due to several factors and the most important ones seem to be: population ageing and more sensitive diagnostic procedures. Secondary – the higher efficacy of treatment with its influence on improving patients’ overall survival and the specific mechanism of action of drugs used in systemic therapy lead to growing population of men suffering from prostate cancer in general and, specifically – patients with castration resistance. It is hormone therapy to play the key role in systemic treatment of prostate cancer with increasing significance of novel drugs focused on inhibition of molecular signal transduction mediated by androgen receptor. Abiraterone acetate is the representative of this therapeutic class. The paper describes the most clinically relevant data regarding the drug.
Management of patient with immune thrombocytopenia with antiphospholipid syndrome and monoclonal gammopathy of undetermined significance
Authors: Ryżewska Wiktoria , Zarzycka Malwina , Witkowski Michał , Witkowska Magdalena , Robak Tadeusz
Published: November 2021

Immune thrombocytopenia with antiphospholipid syndrome and monoclonal gammopathy of undetermined significance poses therapeutic dilemmas – whether we should modify the immune thrombocytopenia treatment in antiphospholipid syndrome, what is the influence of monoclonal gammopathy of undetermined significance on the course of immune thrombocytopenia and whether we should and how to prevent the progression of monoclonal gammopathy of undetermined significance to multiple myeloma.
Bakti Sosial Khitanan Massal
Authors: Dihartawan Dihartawan , Herdiansyah Dadang , Saputra Nazarwin , Suherman Suherman , Romdhona Nur , Al Maududi Abul A'la
Published: November 2021

Tradisi khitan di Indonesia sudah dikenal sejak jaman dahulu, terutama semenjak masuknya Islam ke nusantara. Namun perlu diketahui pula bahwa tradisi khitan ini sesungguhnya sudah ada sejak pertama kali manusia diturunkan ke muka bumi. Nabi adam adalah manusia pertama yang dikhitan. Selain dari sisi perintah agama dari sisi kesehatan khitan pun sangat berpengaruh dalam meningkatkan kesehatan dan mencegah timbulnya penyakit-penyakit yang diakibatkan tidak bersihnya alat kelamin pria ini. WHO pada 2007 menyatakan sirkumsisi memberi manfaat mencegah penularan penyakit HIV/AIDS dan kanker. Ikatan Dokter Anak indonesia pada tahun 2008 juga menyatakan khitan dapat mencegah penumpukan kotoran atau smegma serta mencegah fimosis, yang kedua kondisi ini dapat menyebabkan infeksi pada alat kelamin bayi dan anak. Namun terkadang pelaksanaan khitan ini belum dapat dilakukan karena terkendala faktor biaya yang cukup besar, sehingga pelaksanaannya pun tertunda. Salah satu upaya agar setiap anak dapat melakukan khitan adalah dengan diadakannya bakti sosial khitanan massal. Dan dari kegiatan khitanan massal ini diharapkan akan banyak anak di Indonesia yang dapat dikhitan, sehingga tercapai peningkatan derajat kesehatan dan pertumbuhan anak Indonesia yang baik.---The circumcision tradition in Indonesia has been known since ancient times, especially since the entry of Islam into the archipelago. However, it should also be noted that the circumcision tradition has actually existed since the first time humans were descended to the earth. Prophet Adam was the first man to be circumcised. Apart from the religious orders in terms of circumcision health is also very influential in improving health and preventing the emergence of diseases caused by unclean male genitals. WHO in 2007 said circumcision provided benefits to prevent transmission of HIV / AIDS and cancer. Indonesian Pediatrician Association in 2008 also stated circumcision can prevent the accumulation of dirt or smegma and prevent phimosis, both of these conditions can cause infection of the genitals of infants and children. But sometimes the implementation of circumcision can not be done because of significant cost factors, so the implementation was delayed. One effort that every child can circumcise is to hold a mass circumcision social service. And from this mass circumcision activity, it is expected that many children in Indonesia can be circumcised, so that an improved degree of health and growth of Indonesian children can be achieved.
Edukasi Gerakan Hidup Sehat dengan Aktivitas Fisik Pada Wali Murd Paud Gemilang, Kelurahan Benda Baru
Authors: Ernyasih Ernyasih , Sari Elsa Sylvania , Khairina Najwa , Fauziah Munaya , Andriyani Andriyani , Srisantyorin Triana , Aragar Putri Aragar
Published: November 2021

Perilaku Hidup Bersih dan Sehat merupakan suatu bentuk perilaku keseharian yang sangat penting untuk dilakukan karena mendukung terciptanya kualitas hidup yang lebih baik. Gaya hidup masyarakat sekarang lebih menyukai makanan siap saji, dimana makanan tersebut banyak mengandung lemak, protein, tinggi garam dan rendah serat. Gaya hidup seperti ini dapat menyebabkan berbagai masalah kesehatan antara lain hipertensi, gagal jantung, diabetes mellitus, stroke dan penyakit ginjal.  Dari hasil Musyawarah Masyarakat Desa maka didapatkan satu permasalahan kesehatan di wilayah kerja UPT Puskesmas Benda Baru khususnya di  RW 003 yaitu kurangnya aktivitas Fisik, kurangnya konsumsi buah dan sayur dan merokok. Metode yang digunakan adalah pre dan post test serta edukasi gerakan sehat dengan aktivitas fisik.  Kegiatan penyuluhan ini meningkatkan pengetahuan dan kesadaran masyarakat mengenai pentingnya melakukan aktivitas fisik untuk menurunkan faktor risiko terjadinya Penyakit tidak menular khususnya penyakit Hipertensi wali murid PAUD Gemilang.---Clean and Healthy Living Behavior is a form of daily behavior that is very important to do because it supports the creation of a better quality of life. The lifestyle of people now prefers ready-to-eat food, where these foods contain lots of fat, protein, high salt and low fiber. This lifestyle can cause various health problems including hypertension, heart failure, diabetes mellitus, stroke, and kidney disease. From the results of the Village Community Meeting, one health problem was found in the work area of the Benda Baru Health Center, especially in RW 003, namely lack of physical activity, lack of consumption of fruits and vegetables and smoking. The method used was pre and post-test and healthy movement education with physical activity. This counseling activity increases public knowledge and awareness about the importance of doing physical activity to reduce risk factors for non-communicable diseases, especially hypertension, guardians of PAUD Gemilang students.