bluuebunny/crossref_metadata_2025 huggingface dataset:
‘The very wound of this ill news’: Maximilien Morillon and the impact of bad news during the early years of the Dutch Revolt, 1566–74
Authors: Baars Rosanne M.
Published: October 2022

This article demonstrates the importance that inhabitants of the sixteenth‐century Netherlands, in particular members of the elite, attached to the unpleasant effects of bad news, such as ill health, feelings of uncertainty, and discouragement. It aims to show this through the case study of the correspondence of Maximilien Morillon (1517–1586), vicar‐general of Mechelen and one of the most prolific letter writers from this period. Historians have conceded that the study of news and propaganda constitutes an essential part in understanding the dynamics of early modern conflicts. Yet while they have focused on the content of reports and methods of dissemination, little attention has been paid to the perceived effects of news on its recipients. Within the emotional turn, historians have studied early modern emotional states of grief, anxiety, and depression. Yet their connection with the study of news can arguably be made more explicit. In this article I will synthesize both areas of research, demonstrating how Morillon perceived the impact of bad news during the first years of the Dutch Revolt.
Flexible Domain Prediction using Mixed Effects Random Forests
Authors: Krennmair Patrick , Schmid Timo
Published: October 2022

This paper promotes the use of random forests as versatile tools for estimating spatially disaggregated indicators in the presence of small area-specific sample sizes. Small area estimators are predominantly conceptualised within the regression-setting and rely on linear mixed models to account for the hierarchical structure of the survey data. In contrast, machine learning methods offer non-linear and non-parametric alternatives, combining excellent predictive performance and a reduced risk of model-misspecification. Mixed effects random forests combine advantages of regression forests with the ability to model hierarchical dependencies. This paper provides a coherent framework based on mixed effects random forests for estimating small area averages and proposes a non-parametric bootstrap estimator for assessing the uncertainty of the estimates. We illustrate advantages of our proposed methodology using Mexican income-data from the state Nuevo León. Finally, the methodology is evaluated in model-based and design-based simulations comparing the proposed methodology to traditional regression-based approaches for estimating small area averages.
Two novel platelet biotinylation methods and their impact on stored platelet concentrates in a blood bank environment
Authors: Muret Charlotte , Crettaz David , Martin Agathe , Aliotta Alessandro , Bertaggia Calderara Debora , Alberio Lorenzo , Prudent Michel
Published: October 2022

Background

Storage of platelet concentrates (PCs) has an impact on platelet quality and possibly affects their functions after transfusion. The influence of processing and storage conditions of PCs on their in vivo function upon transfusion is unknown. One option for investigating this question is to implement an ex vivo labeling of human platelets, to analyze them after transfusion into heathy volunteers and/or patients. In this study, we developed two labeling methods employing biotin.

Methods

Two methods of biotinylation were compared to a control (standard PC). The “Bio‐Wash” process used washing steps to label all platelets within the PC; for the other method, “Bio‐Direct,” one fifth of the PC were directly labeled without washing steps. The control and the two biotinylated PCs were analyzed over 7 days of storage. Labeling efficiency, platelet counts, phenotypes, and functions, along with time and costs, were evaluated to select the best process.

Results

Both methods achieved a stable labeling through the storage, with similar platelet counts and metabolism in comparison to control PCs. Bio‐Wash showed higher activation phenotype and lower aggregation response in comparison to the Bio‐Direct method. The Bio‐Direct was performed within 1.5 h versus 3 h for the Bio‐Wash. However, the Bio‐Direct required 12 mg of biotin instead of 8 mg for the other process.

Conclusion

We set up two methods of biotinylation that can be easily implemented in a blood bank environment. The Bio‐Direct process was preferred to the Bio‐Wash because of its similarity, from a functional and phenotypic point of view, with standard PCs.
ACVR and ECVDI consensus statement for the standardization of the abdominal ultrasound examination
Authors: Seiler Gabriela S. , Cohen Eli B. , d'Anjou Marc‐André , French John , Gaschen Lorrie , Knapp Stephanie , Salwei Rochelle M. , Saunders H Mark
Published: October 2022

This consensus statement is designed to provide a standard of care document and describes the ACVR and ECVDI definition for performing a standard abdominal ultrasound examination in dogs and cats. The ACVR and ECVDI define a standard abdominal ultrasonographic examination as a complete exam of the abdominal organs which is appropriately documented. The consensus statement intends to provide guidance to veterinary sonographers and veterinarians for the performance and documentation of high‐quality diagnostic ultrasound examination. The document may also serve as a teaching aid for veterinary students, veterinarians, and residents in diagnostic imaging who seek proficiency in diagnostic ultrasound. Finally, it may serve an additional role in educating the public as to what a high‐quality abdominal ultrasound examination should entail.
Estimation of the Daily Utilizability of a Flat Plate Solar Collector for Different Climatic Zones in Algeria
Authors: Smaili K. , Kasbadji Merzouk N. , Merzouk M. , Boukenoui R.
Published: October 2022

The essential aim of this study is to estimate the daily utilizability and useful energy of a flat-plate solar collector in Algeria for different climatic zones. For this purpose, a program based on Klein’s method was developed to estimate the daily utilizability and the useful energy characterized by the optical efficiency and the global loss coefficient that are equal to 0.72 and 7.9 W/m2K, respectively. The seasonal potentials of the whole studied zones are represented by geographical maps; then, a parametric study is performed to see the influence of the inlet temperature of the heat transfer fluid, the optical efficiency, and the global coefficient losses on the average utilizability per month for each site. Subsequently, the utilizability variations considering different sites and during various months are analyzed in terms of the average temperature of the heat transfer fluid, the optical efficiency, and the coefficient of global losses. The results show that the usable potential produced by this type of solar collector is 1500–1700 MJ/m2 in climatic zones E5 (Tanegrouft), E4 (Sahara), and E3 (Pre-Sahara) and is 1300 MJ/m2 in climatic zones E2 (Highlands) and E1 (Coastal) during the summer season. While for the winter season, the usable potential is 500–700 MJ/m2 in climatic zones E1 and E2, and 700–900 MJ/m2 in E3, E4, and E5, which can be considered the most favorable zones for the conversion of the available solar energy into thermal one through the flat-plate solar collector. The study of the effect on the system performance considering usability has shown that the effects of the overall loss coefficient are more significant compared to optical efficiency.
Tribo-Oxidation and Tribological Behavior of TaC–20%SiC Composites at Elevated Temperatures
Authors: Wu Zihao , Zhang Shubo , Chen Hao , Hai Wanxiu , Liu Meiling , Sun Wenzhou , Qin Falian
Published: October 2022

Tribo-oxidation mechanism and tribological behavior of TaC–20 vol%SiC composites from 25 to 800 °C coupled with aluminum oxide (Al2O3) and cemented carbide (WC–Co) were investigated. Tribo-oxidation products on the worn surface were analyzed by X-ray photoelectron spectroscopy (XPS). The results showed that as temperature increased from 25 °C to 800 °C, the specific wear-rates (WRs) of the composites decreased from 10−3 mm3N−1m−1 to 10−4 mm3N−1m−1 when coupled with Al2O3, while the WRs increased from 10−6 mm3N−1m−1 to 10−3 mm3N−1m−1 continuously when coupled with WC–Co. At 25 °C, TaC in the composite was partially oxidized into TaO2 as coupled with the two dualities. At 400 °C, the TaC in composite was oxidized into Ta2O5, while SiC was oxidized into SiCOx as coupled with Al2O3, while they were oxidized into Ta2O5 and SiO2−x as coupled with WC–Co. At 800 °C, the composites were oxidized into Ta2O5, SiCOx, and SiO2−x as coupled with the two dualities. The segregation of Ta compounds on the surface was promoted by friction. For the composites–Al2O3 tribo-pair, the wear mechanism changed from abrasion and adhesion at low temperature, to abrasion, adhesion, and tribochemical reaction (oxidation) at medium temperature, and adhesion and tribochemical reaction at high temperature. For composites–WC–Co tribo-pair, the wear mechanism was adhesion and tribochemical reaction in the whole temperature range.
A Model for Sound Propagation Through Corrugated Porous Structures With Mean Flow
Authors: Ronge Harshavardhan , Upalkar Shripad , Wagh Akshay , Choudhary Radhika , Krishnan Shankar , Ramamoorthy Sripriya
Published: October 2022

For applications of porous materials where mean pressure drop is a concern, packaging the material into a corrugated structure is better compared to other geometries such as block or wedge shapes. The goal of this study is to integrate noise reduction functionality within that material, which requires an understanding of sound propagation through corrugated porous structures, including flow effects. The corrugated porous structure involves porous partitions separating inlet and outlet fluid channels. The porous materials considered are periodic octet-truss and body-centered cubic unit cells, and sound propagation across these porous partitions is modeled using the Johnson–Champoux–Allard model. The predicted transmission loss (TL) is benchmarked using designed additively manufactured corrugated structures measured using a flow duct. The laminar flow regime is maintained across the porous structure to reduce flow-noise effects. It is shown that the TL for a given corrugated structure increases with a decrease in porosity, and the impact of flow becomes significant as the porosity decreases. The influence of flow on TL also depends on the unit cell configuration. Furthermore, the model provides insights into pressure and acoustic particle velocity distributions within the corrugated structure and reveals regions of the porous material that effectively participate in noise reduction.
Dynamic changes and prognosis of pulmonary congestion by lung ultrasound in hemodialysis patients: a systematic review and meta-analysis
Authors: Zhou Jianan , An Qi , Hou Xiukun
Published: October 2022

Aims: Lung ultrasound (LUS) has been rapidly developed to evaluate pulmonary extravascular fluid. A systematic review was conducted to study the dynamic changes of LUS findings of pulmonary congestion before and after hemodialysis and examine the application of LUS for the prognosis of hemodialysis patients.Material and methods: This study searched online databases for articles on hemodialysis patients that used LUS to evaluate dynamic changes during hemodialysis or prognosis. Articles published in English or Chinese until September 2021 with ≥30 patients were included in this study.Results: Of the 1329 articles, 14 met the inclusion criteria: 9 reported dynamic changes during dialysis in LUS (438 patients), and 5 reported the prognosis of hemodialysis patients in LUS (1274 patients). As indicated by a further meta-analysis, eight studies found that the combined standardized effect size was -0.74. The all-cause mortality rate of the dialysis patient group with high B-line scores was three times that of the dialysis patient group with low B-line scores. In dialysis patients, no difference was found between the LUS guided treatment and the conventional care in reducing the all-cause mortality (HR=0.92 95%CI: 0.67-1.27) and cardiovascular events (HR=0.98 95%CI: 0.72 -1.34).Conclusions: LUS can be used to effectively evaluate the volume status of hemodialysis patients in real time. The level of B-line before dialysis is significantly correlated with the poor prognosis. However, compared with the routine nursing group, the treatment of hemodialysis patients with LUS-guided volume management cannot effectively reduce mortality and cardiovascular events.
Drug Degradation Caused by
mce3R
Mutations Confers Contezolid (MRX-I) Resistance in Mycobacterium tuberculosis
Authors: Pi Rui , Chen Xiaomin , Meng Jian , Liu Qingyun , Chen Yiwang , Bei Cheng , Wang Chuan , Gao Qian
Published: October 2022

Contezolid (MRX-I), a safer antibiotic of the oxazolidinone class, is a promising new antibiotic with potent activity against
Mycobacterium tuberculosis
(MTB) both
in vitro
and
in vivo
. To identify resistance mechanisms of contezolid in MTB, we isolated several
in vitro
spontaneous contezolid-resistant MTB mutants, which exhibited 16-fold increases in the MIC of contezolid compared with the parent strain but were still unexpectedly susceptible to linezolid.
Arbuscular Mycorrhiza and Nitrification: Disentangling Processes and Players by Using Synthetic Nitrification Inhibitors
Authors: Dudáš Martin , Pjevac Petra , Kotianová Michala , Gančarčíková Kateřina , Rozmoš Martin , Hršelová Hana , Bukovská Petra , Jansa Jan
Published: October 2022

Nitrogen is one of the most important elements for all life on Earth. In soil, N is present in various chemical forms and is fiercely competed for by various microorganisms as well as plants.
Optimizing the Live Attenuated Influenza A Vaccine Backbone for High-Risk Patient Groups
Authors: Bonifacio João P. P. L. , Williams Nathalia , Garnier Laure , Hugues Stephanie , Schmolke Mirco , Mazel-Sanchez Beryl
Published: October 2022

Live attenuated influenza vaccine (LAIV) is a needle-free, mucosal vaccine approved for healthy 2- to 49-year old individuals. Its replicative nature and higher rate of adverse events excludes at-risk populations.
Cation ATPase (ATP4) Orthologue Replacement in the Malaria Parasite Plasmodium knowlesi Reveals Species-Specific Responses to ATP4-Targeting Drugs
Authors: Mohring Franziska , van Schalkwyk Donelly A. , Henrici Ryan C. , Blasco Benjamin , Leroy Didier , Sutherland Colin J. , Moon Robert W.
Published: October 2022

Effective drugs are vital to minimize the illness and death caused by malaria. Development of new drugs becomes ever more urgent as drug resistance emerges.
Basaltic Lava Tube Hosts a Putative Novel Genus in the FamilySolirubrobacteraceae
Authors: Fishman C. B. , Bevilacqua J. G. , Gadson O. , Hahn A. S. , McAdam A. C. , Bleacher J. , Johnson S. S.
Published: October 2022

We report the draft genome sequence of a putative new genus and species,Siliceabacter maunaloa, in the familySolirubrobacteraceae. The members of this family ofActinobacteriaare generally Gram positive and mesophilic. Found within a Hawaiian lava tube, this microbe illuminates the types of prokaryotes inhabiting secondary minerals in subsurface basaltic environments.
Metagenome-Assembled Genome of
Acidibrevibacterium fodinaquatile
FLA01 from Fumarole Sediments from the Los Azufres Geothermal Field
Authors: Bolivar-Torres Hermes H. , Marín-Paredes Roberto , Ramos-Madrigal Cristal , Servín-Garcidueñas Luis E.
Published: October 2022

The Los Azufres geothermal field contains diverse microbial communities inhabiting thermal springs whose bacterial genomic diversity is being analyzed. Here, we describe a metagenome-assembled genome of
Acidibrevibacterium fodinaquatile
FLA01 obtained from fumarole sediment sequencing data. The genome contained genes for carbon fixation, osmotic shock, and heavy metal resistance.
ALIBY: ALFA Nanobody-Based Toolkit for Imaging and Biochemistry in Yeast
Authors: Akhuli Dipayan , Dhar Anubhav , Viji Aileen Sara , Bhojappa Bindu , Palani Saravanan
Published: October 2022

In yeast research, conventional fluorescent protein tags and small epitope tags are widely used to study the spatiotemporal dynamics and activity of proteins. Although proven to be efficient, these tags lack the versatility for use across different cell biological and biochemical studies of a given protein of interest.
In Vitro
and
In Vivo
Antimicrobial Activity of Hypochlorous Acid against Drug-Resistant and Biofilm-Producing Strains
Authors: Palau Marta , Muñoz Estela , Lujan Enric , Larrosa Nieves , Gomis Xavier , Márquez Ester , Len Oscar , Almirante Benito , Abellà Jordi , Colominas Sergi , Gavaldà Joan
Published: October 2022

Currently, drug-resistant infections are increasing and there are fewer antibiotics available to treat them. Therefore, there is an urgent need to find new antibiotics and nonantimicrobial strategies to treat these infections. We present a new nonantibiotic strategy based on hypochlorous acid generation to treat long-term catheter-related and chronic wounds infections.
Dynamic Changes in Fermentation Quality and Structure and Function of the Microbiome during Mixed Silage of
Sesbania cannabina
and Sweet Sorghum Grown on Saline-Alkaline Land
Authors: Wang Tianwei , Zhang Jiaqi , Shi Weixiong , Sun Jiahao , Xia Tianqi , Huang Fuqing , Liu Yayong , Li Huangkeyi , Teng Kunling , Zhong Jin
Published: October 2022

The coensiling of
Sesbania cannabina
and sweet sorghum is of great practical importance in order to alleviate the protein-rich forage deficiency in saline-alkaline regions. Furthermore, understanding the microbial community’s dynamic changes, interactions, and metabolic pathways during ensiling will provide the theoretical basis to effectively regulate silage fermentation.
A High Daptomycin Dose Is Associated with Better Bacterial Clearance in Infections Caused by Vancomycin-Resistant Enterococcus faecium Regardless of Daptomycin Minimum Inhibitory Concentration in a Rat Infective Endocarditis Model
Authors: Wang Jann-Tay , Yang Chia-Jui , Yang Jia-Ling , Lin Shu-Wen , Chuang Yu-Chung , Sheng Wang-Huei , Chen Yee-Chun , Chang Shan-Chwen
Published: October 2022

Using a rat IE model with pharmacokinetic analysis, the treatment response of VREf IE was found to be daptomycin dose-dependent, presented as
Cmax
/MIC or as the 24 h area under the concentration-time curve (AUC
0–24
)/MIC. Daptomycin 90 mg/kg s.c. significantly reduced the bacterial load against DSE and DNSE.
Consistency of covid-19 trial preprints with published reports and impact for decision making: retrospective review
Authors: Zeraatkar Dena , Pitre Tyler , Leung Gareth , Cusano Ellen , Agarwal Arnav , Khalid Faran , Escamilla Zaira , Cooper Matthew Adam , Ghadimi Maryam , Wang Ying , Verdugo-Paiva Francisca , Rada Gabriel , Kum Elena , Qasim Anila , Bartoszko Jessica Julia , Siemieniuk Reed Alexander Cunningham , Patel Chirag , Guyatt Gordon , Brignardello-Petersen Romina
Published: October 2022

Objective

To assess the trustworthiness (ie, complete and consistent reporting of key methods and results between preprint and published trial reports) and impact (ie, effects of preprints on meta-analytic estimates and the certainty of evidence) of preprint trial reports during the covid-19 pandemic.

Design

Retrospective review.

Data sources

World Health Organization covid-19 database and the Living Overview of the Evidence (L-OVE) covid-19 platform by the Epistemonikos Foundation (up to 3 August 2021).

Main outcome measures

Comparison of characteristics of covid-19 trials with and without preprints, estimates of time to publication of covid-19 preprints, and description of differences in reporting of key methods and results between preprints and their later publications. For the effects of eight treatments on mortality and mechanical ventilation, the study comprised meta-analyses including preprints and excluding preprints at one, three, and six months after the first trial addressing the treatment became available either as a preprint or publication (120 meta-analyses in total, 60 of which included preprints and 60 of which excluded preprints) and assessed the certainty of evidence using the GRADE framework.

Results

Of 356 trials included in the study, 101 were only available as preprints, 181 as journal publications, and 74 as preprints first and subsequently published in journals. The median time to publication of preprints was about six months. Key methods and results showed few important differences between trial preprints and their subsequent published reports. Apart from two (3.3%) of 60 comparisons, point estimates were consistent between meta-analyses including preprints versus those excluding preprints as to whether they indicated benefit, no appreciable effect, or harm. For nine (15%) of 60 comparisons, the rating of the certainty of evidence was different when preprints were included versus being excluded—the certainty of evidence including preprints was higher in four comparisons and lower in five comparisons.

Conclusion

No compelling evidence indicates that preprints provide results that are inconsistent with published papers. Preprints remain the only source of findings of many trials for several months—an unsuitable length of time in a health emergency that is not conducive to treating patients with timely evidence. The inclusion of preprints could affect the results of meta-analyses and the certainty of evidence. Evidence users should be encouraged to consider data from preprints.
COVID-19 during pregnancy and risk of pregnancy loss (miscarriage or stillbirth): a systematic review protocol
Authors: Campbell Jennifer , Williams Rachael , Harley Mia , Bhaskaran Krishnan
Published: October 2022

Introduction

The COVID-19 pandemic has led to concerns about potential adverse pregnancy outcomes associated with infection, resulting in intensive research. Numerous studies have attempted to examine whether COVID-19 is associated with an increased risk of pregnancy loss. However, studies and reviews to date have drawn differing conclusions. The aim of this systematic review is to provide a summary of all quantitative research on the relationship between pregnancy loss and COVID-19 infection and, if appropriate, to synthesise the evidence into an overall effect estimate.

Methods and analysis

Three publication databases (Embase, PubMed and Cochrane) and four preprint databases (medRxiv, Lancet Preprint, Gates Open Research and Wellcome Open Research) will be searched. Boolean logic will be used to combine terms associated with pregnancy loss and COVID-19. The population of interest are pregnant women. Retrieved results will be assessed in two phases: (1) abstract screening and (2) full text evaluation. All studies which compare pregnancy loss outcomes in women who had COVID-19 versus those who did not quantitatively will be included. Narrative and non-English studies will be excluded. Two reviewers will screen independently, with results compared and discrepancies resolved by the study team. Study quality and risk of bias will be assessed using a quality appraisal tool. Results will be summarised descriptively and where possible synthesised in a meta-analysis.

Ethics and dissemination

This systematic review requires no ethical approval. This review will be published in a peer-reviewed journal and provide an important update in a rapidly evolving field of research.

PROSPERO registration number

CRD42022327437.
TiO2nanoparticles abrogate the protective effect of the Crohn’s disease-associated variation within the PTPN22 gene locus
Authors: Schwarzfischer Marlene , Niechcial Anna , Handler Kristina , Morsy Yasser , Wawrzyniak Marcin , Laimbacher Andrea S , Atrott Kirstin , Manzini Roberto , Baebler Katharina , Hering Larissa , Katkeviciutė Egle , Häfliger Janine , Lang Silvia , Keller Maja E , Woodtli Jérôme , Eisenbeiss Lisa , Kraemer Thomas , Schraner Elisabeth M , Wiesendanger Mahesa , Zeissig Sebastian , Rogler Gerhard , Moor Andreas E , Scharl Michael , Spalinger Marianne R
Published: October 2022

Objective

Inflammatory bowel disease (IBD) is a multifactorial condition driven by genetic and environmental risk factors. A genetic variation in the protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene has been associated with autoimmune disorders while protecting from the IBD subtype Crohn’s disease. Mice expressing the murine orthologous PTPN22-R619W variant are protected from intestinal inflammation in the model of acute dextran sodium sulfate (DSS)-induced colitis. We previously identified food-grade titanium dioxide (TiO2, E171) as a neglected IBD risk factor. Here, we investigate the interplay of the PTPN22 variant and TiO2-mediated effects during IBD pathogenesis.

Design

Acute DSS colitis was induced in wild-type and PTPN22 variant mice (PTPN22-R619W) and animals were treated with TiO2nanoparticles during colitis induction. Disease-triggering mechanisms were investigated using bulk and single-cell RNA sequencing.

Results

In mice, administration of TiO2nanoparticles abrogated the protective effect of the variant, rendering PTPN22-R619W mice susceptible to DSS colitis. In early disease, cytotoxic CD8+T-cells were found to be reduced in the lamina propria of PTPN22-R619W mice, an effect reversed by TiO2administration. Normalisation of T-cell populations correlated with increasedIfngexpression and, at a later stage of disease, the promoted prevalence of proinflammatory macrophages that triggered severe intestinal inflammation.

Conclusion

Our findings indicate that the consumption of TiO2nanoparticles might have adverse effects on the gastrointestinal health of individuals carrying the PTPN22 variant. This demonstrates that environmental factors interact with genetic risk variants and can reverse a protective mechanism into a disease-promoting effect.
Effect of the anastomosis between the posterior inferior cerebellar artery and the superior cerebellar artery on outcomes of acute basilar artery occlusion after endovascular treatment
Authors: Huang Jiacheng , Kong Weilin , Yang Jie , Wang Maolin , Huang Xianjun , Wang Yan , Luo Jun , Wu Youlin , Zeng Guoyong , Wan Yue , Song Jiaxing , Li Linyu , Hu Jinrong , Liu Shuai , Luo Weidong , Tian Yan , Sang Hongfei , Qiu Zhongming , Li Fengli , Schonewille Wouter , Liu Chang , Zi Wenjie
Published: October 2022

Background

The effects of secondary collateral compensation on outcomes remain unclear in patients with acute basilar artery occlusion (BAO) after endovascular treatment (EVT). This study aimed to evaluate the benefits of the anastomosis between the posterior inferior cerebellar artery (PICA) and the superior cerebellar artery (SCA) in BAO after EVT.

Methods

This cohort study was conducted using data from the Endovascular Treatment for Acute Basilar Artery Occlusion Study Registry. Patients with acute BAO and treated with EVT were included. The primary outcome was a modified Rankin Scale score of 0–2 at 90 days. Safety outcomes included symptomatic intracerebral hemorrhage (SICH) and 90-day mortality.

Results

Of the 646 patients included in the study, 196 (30.3%) patients had a PICA–SCA anastomosis. The PICA–SCA anastomosis was significantly associated with independent functional outcome at 90 days (67/196 (34.2%) vs 109/450 (24.2%), adjusted OR (aOR) 1.80 (95% CI 1.13 to 2.86), p=0.01) and was significantly associated with a decreased rate of SICH (40/442 (9.0%) vs 5/193 (2.6%), aOR 0.29 (95% CI 0.11 to 0.76), p=0.01). No significant difference was found between PICA–SCA anastomosis and 90-day mortality (219/450 (48.7%) vs 80/196 (40.8%), aOR 0.72 (95% CI 0.48 to 1.08), p=0.11). Subgroup analysis showed that the association between independent functional outcome and PICA–SCA anastomosis was strongest in patients with middle BAO (27/77 (35.1%) vs 22/118 (18.6%), aOR 2.64 (95% CI 1.13 to 6.15), p=0.03).

Conclusions

The PICA–SCA anastomosis is significantly associated with better functional outcomes in patients with acute BAO after EVT, especially in those with middle BAO.
Time-dependent condensation of bosonic potassium
Authors: Kabelac A. , Wolschin G.
Published: October 2022

We calculate the time-dependent formation of Bose–Einstein condensates (BECs) in potassium vapours based on a previously derived exactly solvable nonlinear boson diffusion equation (NBDE). Thermalization following a sudden energy quench from an initial temperature $$T_\mathrm {i}$$

T
i

to a final temperature $$T_\mathrm {f}$$

T
f

below the critical value and BEC formation are accounted for using closed-form analytical solutions of the NBDE. The time-dependent condensate fraction is compared with available $$^{39}$$

39

K data for various scattering lengths.

Graphic Abstract
Tanshinone IIA Microemulsion Protects against Cerebral Ischemia Reperfusion Injury via Regulating H3K18ac and H4K8acIn VivoandIn Vitro
Authors: Ma Hui , Hu Zeng-Chun , Long Yu , Cheng Li-Chun , Zhao Chen-Yang , Shao Ming-Kun
Published: October 2022

Tanshinone IIA (TanIIA) has neuroprotective effects against cerebral ischemia reperfusion injury (CIRI), but its clinical application is limited due to poor water solubility and robust first pass elimination property. In this study, we developed microemulsion loaded with TanIIA (TanIIA ME) to break through these limitations, and explored the neuroprotective effect of TanIIA ME against CIRI and the epigenetic regulation mechanism of this neuroprotection. In vivo, middle cerebral artery occlusion (MCAO) models were treated with TanIIA ME and TanIIA solution or sodium valproate as a control. The effect of TanIIA ME on HDAC activity was determined by ELISA assay. In addition, we used primary hippocampal neurons to establish oxygen-glucose deprivation and reoxygenation (OGD/R) models. Lactate dehydrogenase (LDH) assay and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay were performed to investigate the neuroprotective efficacy of TanIIA ME. Subsequently, the expression of H3K18ac, H4K8ac, NMDAR1, caspase-3, and MAP-2 were investigated in MCAO or OGD/R models treated with TanIIA ME, TanIIA solution or sodium valproate. In vivo experimental results indicated that TanIIA ME significantly reduced neurological scores, infarction volume, and HDAC activity compared with TanIIA solution and MCAO group, accompanied by upregulation of H3K18ac, H4K8ac, and MAP-2 expression and downregulation of NMDAR1 and caspase-3 expression. Additionally, in OGD/R models, the results demonstrated that TanIIA ME treatment had a better neuroprotective effect along with increased H3K18ac, H4K8ac, and MAP-2 expression and decreased NMDAR1 and caspase-3 expression, compared with the other treatments except sodium valproate. Overall, TanIIA ME treatment exhibited superior efficacy in protecting against CIRI through mechanisms that might involve the inhibition of NMDAR1 and caspase-3 expression and the enhancement of MAP-2 expression by regulating histone H3K18 and H4K8 acetylation. Thus, TanIIA ME could be potentially used to develop a promising drug for the treatment of ischemic stroke.
Quantum coherence and parameter estimation for mixed entangled coherent states
Authors: Algarni Mariam , Berrada K. , Abdel-Khalek S.
Published: October 2022

We study the temporal evolution of quantum coherence and parameter estimation for two-mode coherent-state superposition by using the master equation. Analytic expressions are provided and numerically displayed, which can illustrate the reliance of the coherence and Fisher information during the dynamics. Generally, we find that the amount of the quantum measures has the same behavior during the time variation, and displays a different order that depends on the different strength regimes of the input radiation fields and then disappears at infinite times. We show that these measures start from maximal value at the initial instant and decrease the time goes on. Moreover, we can observe that these measures can be protected resisted from the environment effect during the dynamics, showing an important feature of coherence and Fisher information. The obtained results can be assumed more practical in the characterization of the behavior of the coherence and Fisher information under the effect of the environment. Our observations can provide significant implications in harnessing these phenomena in quantum optics and information.
SOME CHAOTIC MATHEMATICAL MODELS WITH STOCHASTIC RESETTING
Authors: KOCA ILKNUR , ATANGANA ABDON
Published: October 2022

A system of three nonlinear equations that depict chaotic behavior was considered in this work. We looked at four cases: one with a power-law property; one with a fading memory effect; one with a transition from stretched exponential to power-law; and one with a stochastic component. We have presented a detailed analysis of stability and we have suggested a number similar to the reproductive number in the case of epidemiology. At this stage, we did not provide a physical meaning for such a number. However, such a number may be useful. A numerical scheme based on the Lagrange polynomial interpolation was used to solve the respective models numerically. Numerical simulations were performed for different values of fractional orders and densities of randomness and piecewise ideas.
Challenges and opportunities for hydrocarbon exploration within the Mesozoic sub-basalt plays of the Norwegian Atlantic Margin
Authors: Kilhams Ben , Chedburn Lauren , Layfield Lucinda , Schofield Nick , Løkling Lunde Ingelin , Kennan Lorcan , Romain Hollie , Jolley David , Eide Christian Haug
Published: October 2022

The sub-basalt domain of the Norwegian continental shelf (NCS) is one of the last remaining hydrocarbon exploration frontiers in Europe. While there is an established geological and tectonic framework, little has been published that addresses the remaining hydrocarbon exploration risks/uncertainties. Unlike the Faroe Shetland Basin and Rockall Trough, at the time of writing, there are currently no industry-drilled sub-basalt well penetrations on the Norwegian continental shelf. Numerous potential Mesozoic sub-basalt hydrocarbon plays exist on the NCS but, due to the lack of industry-drilled sub-basalt penetrations, there is a perceived large exploration risk. By using cross-border analogues, basin modelling workflows and integration of available seismic data the main uncertainties across the NCS are outlined including charge timing, structural definition, and details of reservoir presence. Generically the Late Cretaceous and Middle Jurassic intervals are potential plays which may be present on the Norwegian Margin. However, there is considerable uncertainty on their depth and preservation. Although significant challenges and uncertainties remain, the authors believe that the integration of well results, consideration of basin modelling driven heat flow estimates and new 3D seismic data may open sub-basalt opportunities for a new exploration frontier on the NCS.

Thematic collection:
This article is part of the New learning from exploration and development in the UKCS Atlantic Margin collection available at
https://www.lyellcollection.org/topic/collections/new-learning-from-exploration-and-development-in-the-ukcs-atlantic-margin
The Perception of Teachers on Usability and Accessibility of Programming Materials for Children with Visual Impairments
Authors: van der Meulen Anna , Hartendorp Mijke , Voorn Wendy , Hermans Felienne
Published: October 2022

Programming education is strongly emerging in elementary and high school. Diversity and inclusion are important topics, however, insights on suited programming materials for younger learners with visual impairments are lacking. A wide range of programming materials for children exists, diverse in both what is being programmed (output) and how this is done (input), yet often relying on visual features. An understanding of the usability and accessibility aspects of these different materials is important to inform educational practice and to increase understanding of what makes programming materials suited for low vision and blind children. The aim of this study is to explore the usability and accessibility of programming materials currently used in education to low vision and blind children in the Netherlands. A focus group was conducted with six teachers or IT experts, all working with the target group in special education. The thematic analysis of the discussion of 25 materials (including unplugged lessons, robots and robotic kits, block-based and text-based languages) showed the potential of several materials, especially unplugged lessons, and the continuing search for suited materials and workforms specifically for the blind children. Furthermore, prioritizing “fun” and close connections to children’s daily life as well as careful explorations of usability at the cognitive level came forward as important factors for future research and development in programming materials for low vision and blind children. These insights can contribute to obtaining an inclusive approach to programming for young learners.
Boosting the Selective Electrochemical Signals for Simultaneous Determination of Chloramphenicol and Furazolidone in Food Samples by Using ZnFe2O4-Based Sensing Platform: Correlation between Analyte Molecular Structure and Electronic Property of Electrode Materials
Authors: Huyen Nguyen Ngoc , Anh Nguyen Tuan , Phung Thi Lan Huong , Dinh Ngo Xuan , Vinh Nguyen Thanh , Loan To Thanh , Nguyen Van Quy , Vu Dinh Lam , Tung Le Minh , Le Anh-Tuan
Published: October 2022

In this study, ZnFe2O4-based nanostructures, including ZnFe2O4 nanoparticles and ZnFe2O4/ZnO nanocomposite, were introduced on screen-printed electrodes surface (SPEs) for enhancing the selective electrochemical signals towards the chloramphenicol (CAP) and furazolidone (FZD) antibiotics. The difference in the molecular structure of CAP and FZD leads to significant changes in adsorption capacity and electron transfer kinetic at modified electrodes. Interestingly, FZD antibiotic with formal reduction potential (E0’) near the Fermi level of ZnFe2O4-based nanostructures showed a strong dependence of electrochemical response with electron transfer kinetic. In contrast, CAP antibiotic with E0’ away from the Fermi level of ZnFe2O4-based nanostructures showed the high sensitivity of electrochemical response with the electroactive surface area of modified electrodes. The obtained results might offer the basis to develop a suitable approach for improving the analytical performance of advanced spinel oxide nanostructures-based electrochemical sensing devices. Under optimal conditions, ZnFe2O4/ZnO/SPEs enabled the simultaneous monitoring of CAP and FZD in the linear working ranges of 0.5–100 μM and 0.5–75 μM with high electrochemical sensitivity of 1.87 and 1.82 μA μM−1 cm−2, respectively. The ZnFe2O4-based electrochemical nanosensor exhibited high repeatability and long-term storage stability for simultaneous analysis of CAP and FZD in milk sample.
∆nFGF1 Protects β-Cells against High Glucose-Induced Apoptosis via the AMPK/SIRT1/PGC-1α Axis
Authors: Chen Qiong , Chen Xinwei , Jia Zhenyu , Du Yali , Zhang Shujun , Xu Wenxin , Pan Beibin , Lou Jiaxin , Zhou Jianhui , Zhou Jie , Sun Jian
Published: October 2022

Long-term exposure to high glucose leads to β-cell dysfunction and death. Fibroblast growth factor 1 (FGF1) has emerged as a promising diabetes treatment, but its pharmaceutical role and mechanism against glucolipotoxicity-induced β-cell dysfunction remain uncharacterized. Wild-type FGF1 (FGF1WT) may exhibit in vivo mitogenicity, but deletion of N-terminal residues 1-27 gives a nonmitogenic variant, ∆nFGF1, that does not promote cell proliferation and still retains the metabolic activity of FGF1WT. To investigate the roles of ∆nFGF1 on glucose regulation and potential islet β-cell dysfunction, db/db mice were used as a model of type 2 diabetes. The results showed that insulin secretion and apoptosis of islet β-cells were dramatically improved in ∆nFGF1-treated db/db mice. To further test the effects of ∆nFGF1 treatment, pancreatic β-cell (MIN6) cells were exposed to a mixture of palmitic acid (PA) and high glucose (HG) to mimic glucolipotoxic conditions in vitro. Treatment with ∆nFGF1 significantly inhibited glucolipotoxicity-induced apoptosis. Mechanistically, ∆nFGF1 exerts a protective effect on β-cells via activation of the AMPK/SIRT1/PGC-1α signaling pathway. These findings demonstrate that ∆nFGF1 protects pancreatic β-cells against glucolipotoxicity-induced dysfunction and apoptosis.
Evaluation of Castor (Ricinus communis L.) Genotypes and Their Feeding Values on Rearing Performance of Eri Silkworm (Samia cynthia ricini Boisduval) (Lepidoptera: Saturniidae) in Southwest Ethiopia
Authors: Tulu Dereje , Aleme Melkam , Mengistu Gezahegn , Bogale Ararsa , Shifa Kedir , Mendesil Esayas
Published: October 2022

The quality of feed plays an important role in the growth and development of silkworms and eventually in the economic traits of cocoons. This study was conducted to evaluate ten castors (Ricinus communis L.) genotypes and their feeding values on the rearing performance of Eri Silkworm (Samia cynthia ricini Boisduval) (Lepidoptera: Saturniidae) at Tepi, southwest Ethiopia. A total of ten castor genotypes were evaluated in a randomized complete block design (RCBD), and the suitability of castor genotypes as feed for a mixed strain of Eri-silkworm was also evaluated in a completely randomized design (CRD) under laboratory conditions. A hundred worms were used in each replication. Castor genotypes showed significant differences in fresh leaf yield. Among the castor genotypes tested, genotype 219645 recorded 439 g of ten fresh leaf yields. Results of Eri-silkworm rearing performance depict that a shorter larval period (22 days), a higher effective rate of rearing (94.54%), and a shorter life cycle (58 days) were observed in Eri-silkworm fed on leaves of the 200390 genotype, while a higher larval weight (6.16 g) was recorded in the Abaro genotype. However, higher cocoon weight (3.26 g), pupal weight (2.46 g), shell weight (0.45 g), and silk ratio (13.80%) were found in Eri-silkworms fed on leaves of genotype 219645. Hence, based on silkworm rearing performance, genotype 219645 showed relatively superior results and is recommended for future development work. Further studies should continue giving more emphasis to the multilocation study of genotype 219645 to understand its performance in the diverse growing environment.
Cordycepin Induces Apoptosis through JNK-Mediated Caspase Activation in Human OEC-M1 Oral Cancer Cells
Authors: Tung Kuo-Lung , Wu Su-Zhen , Yang Chun-Chuan , Chang Hong-Yi , Chang Chun-Sheng , Wang Yan-Hsiung , Huang Bu-Miin , Lan Yu-Yan
Published: October 2022

Cordycepin, a bioactive compound extracted from Cordyceps sinensis, can induce apoptosis in human OEC-M1 oral cancer cells. However, the exact mechanism is still unclear. The present study aimed to investigate the underlying mechanism of cordycepin-induced apoptosis in OEC-M1 cells. Following treatment with cordycepin, apoptosis was examined and quantified using a DNA laddering assay and a cytokeratin 18 fragment enzyme-linked immunosorbent assay, respectively. Expressions of mitogen-activated protein kinases (MAPKs) and apoptosis-related proteins were detected by the western blot analysis. Our results show that a pan-caspase inhibitor, Z-VAD-FMK, could significantly inhibit cordycepin-induced apoptosis in OEC-M1 cells. In addition, treatment with cordycepin not only activated caspase-8, caspase-9, and caspase-3 but also induced Bid and poly ADP-ribose polymerase cleavages. Furthermore, cordycepin also induced the activation of c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase, and p38 MAPKs. Among MAPKs, activation of JNK solely contributed to cordycepin-induced apoptosis with the activation of caspase-8, caspase-9, and caspase-3 and cleavage of PARP. Taken together, the present study demonstrated that cordycepin activated JNK and caspase pathways to induce apoptosis in OEC-M1 cells.
Mobile App News English Communication Based on Machine Learning Algorithm
Authors: Zhang Jun
Published: October 2022

With the rapid development of information technology, especially wireless Internet, the application of mobile terminals has gradually become an indispensable part of people’s life and provides new opportunities for higher education. At present, with the rise of the Internet, Chinese English online media have mushroomed and are facing fierce competition. In order to further test the current communication strategies of mobile app News English, this paper uses machine learning algorithms to capture the superficial and deep semantic features of words and sentences in English news and comprehensively uses existing methods to express semantic features. The surface and deep parts of English news are analyzed and classified by regression calculation. Then, in order to analyze the communication of mobile app English news, this paper uses random questionnaires and interviews to investigate students, combined with machine learning algorithm knowledge, analyzes the communication effect of Chinese English news mobile program on college students, and analyzes its influencing factors on the communication effect of news. It is hoped that the results of this study can clearly identify the advantages and disadvantages of English News Mobile Applications in the development of the current era and timely adjust strategic decisions. By studying machine learning algorithm and introducing it into the field of English news communication, this paper tests an English news communication mobile app and analyzes its effect on English news communication.
Evaluation of IoT-Enabled Interactive UI Design Effect Based on the Discrete Mathematical Model
Authors: Sun Han , Kim KieSu
Published: October 2022

Today, the Internet of Things (IoT), often referred to as smart home technology, is used by many individuals in their daily life. The majority of IoT devices include a companion mobile application that consumers must install on their tablet or smartphone to operate, configure, and interface with the IoT device. Multiple kinds of IoT systems have grown in popularity alongside the growth of information engineering. The accessibility of a user interface (UI) in an IoT system is becoming increasingly crucial. This causes major issues with accuracy and evaluation time. This research suggests a discrete mathematical model for IoT-enabled interactive UI design impact assessment approach to address the concerns of low evaluation accuracy and long evaluation time in existing interactive UI design effect evaluation methods. It creates an IoT-enabled interactive UI design effect assessment index system using interactive UI design vision, hearing, and feeling. It gets IoT-enabled interactive UI design effect evaluation indexes, builds a judgment matrix, derives the weight coefficient of each evaluation index, and employs the hierarchy based on the weight coefficient produced. To complete the assessment of the IoT-enabled interactive UI design effect, the analytical approach evaluates the relative value of the seven evaluation indicators by utilizing the discrete Hopfield neural network to develop the evaluation mathematical model. The simulation results reveal that the suggested method’s IoT-enabled interactive UI design effect evaluation accuracy is greater, while the evaluation time is shorter.