bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Return on Equity, Asset Growth dan Price Earnings Ratio terhadap Harga Saham Perusahaan Sektor Pertambangan yang Terdaftar di Bursa Efek Indonesia Periode 2014-2016
Authors: Hokardi Silvanus Hardianto , Firdausy Carunia Mulya
Published: January 2021

This research aims to discuss the effects of equity, asset growth, and the ratio of price earnings on the price of shares of companies listed on the Indonesia Stock Exchange in the 2014-2016 period. Samples were taken using a purposive sampling technique. A total of 60 samples were taken from 20 companies for 3 years. The statistical method to examine the objective of multiple linear regression. This showed that equity returns have a significant effect on stock prices, whilst asset growth and price earnings ratios have no significant effect on stock prices. Taken together, the return on equity, asset growth and price earnings ratios have a significant effect on stock prices. Penelitian ini bertujuan untuk menguji pengaruh return on equity, asset growth dan price earnings ratio terhadap harga saham perusahaan sektor pertambangan yang terdaftar di Bursa Efek Indonesia periode 2014-2016. Sampel diambil dengan menggunakan teknik purposive sampling. Jumlah sampel sebanyak 60 yang diambil dari 20 perusahaan selama 3 tahun. Metode analisis yang digunakan yakni analisis regresi berganda. Sedangkan, uji hipotesisnya menggunakan uji t, dan uji F. Hasil studi ini menunjukkan bahwa return on equity berpengaruh signifikan terhadap harga saham. Sedangkan, asset growth dan price earnings ratio tidak berpengaruh signifikan terhadap harga saham. Namun hasil uji F diperoleh hasil bahwa secara bersama-sama return on equity, asset growth dan price earnings ratio mempunyai pengaruh yang signifikan terhadap harga saham.
Pengaruh Diversifikasi dan Pengelolaan Modal Kerja terhadap Nilai Perusahaan dan Profitabilitas (ROA) pada Perusahaan Manufaktur Sub Sektor Makanan dan Minuman yang Terdaftar di Bursa Efek Indonesia (BEI) Periode 2016-2018
Authors: Putri Mashudiah Sainul , Susanto Eko Harry
Published: January 2021

This study aims to examine the effect of diversification and working capital management (inventory periods, accounts receivable periods, accounts payable periods, cash conversion cycles) on firm value and profitability of ROA on food and beverage sub-sector manufacturing companies listed on the Indonesia Stock Exchange during the 2016-2018 period. The method used is multiple linear regression test (T-test and F-test) using Eviews 8.0. Samples were selected using a purposive sampling method, which consisted of 12 companies that met the criteria and obtained 36 research sample data. The results of this study indicate that the inventory period and the receivable period significantly influence the value of the company, and the inventory period, the receivable period, the debt period and the cash conversion cycle also have a significant effect on the profitability (ROA) of the company. Penelitian ini bertujuan untuk menguji pengaruh diversifikasi dan pengelolaan modal kerja (periode persediaan, periode piutang, periode hutang, siklus konversi kas) terhadap nilai perusahaan dan profitabilitas ROA (Return on Assets) pada perusahaan manufaktur sub sektor makanan dan minuman yang terdaftar di Bursa Efek Indonesia selama periode 2016-2018. Metode yang digunakan yaitu uji regresi linear berganda (uji-T dan uji-F) dengan menggunaan Eviews 8.0. Sampel diseleksi dengan menggunakan metode purposive sampling, yang terdiri dari 12 perusahaan yang memenuhi kriteria dan diperoleh 36 data sampel penelitian. Hasil penelitian ini menunjukkan bahwa periode persediaan dan periode piutang berpengaruh signifikan terhadap nilai perusahaan, serta periode persediaan, periode piutang, periode hutang dan siklus konversi kas juga berpengaruh signifikan terhadap profitabilitas (ROA) perusahaan.
Pengaruh Financial Knowledge, Financial Satisfaction, Financial Confidence terhadap Financial Behavior
Authors: Wijaya Iskandy , Yanuar Yanuar
Published: January 2021

The purpose of this study is to analyze the effect of Financial Satisfaction, Financial Knowledge, Financial Confidence on Financial Behavior. This study uses the theory of planned behavior and financial behavior theory. The problem in this research is to find out the factors that can improve an individual's financial behavior in making appropriate financial decisions. This study uses a conclusive and descriptive research design. This research data is primary data obtained by a cross-sectional design. The sampling technique of this study was non-probability sampling using convenience sampling. This research was conducted with OVO application users in UNTAR. The results of this study indicate that Financial Knowledge and Financial Confidence have a significant effect on Financial Behavior while Financial Satisfaction does not affect Financial Behavior. Tujuan penelitian ini adalah untuk menganalisis pengaruh Financial Satisfaction, Financial Knowledge, Financial Confidence terhadap Financial Behavior. Penelitian ini menggunakan teori perilaku terencana dan teori perilaku keuangan. Masalah dalam penelitian ini yaitu untuk mengetahui faktor yang dapat meningkatkan perilaku keuangan individu dalam pengambilan keputusan keuangan yang tepat. Penelitian ini menggunakan desain penelitian konklusif dan deskriptif. Data penelitian ini merupakan data primer yang diperoleh dengan cross-sectional design. Teknik pengambilan sampel penelitian ini adalah non-probability sampling dengan menggunakan convenience sampling. Penelitian ini dilakukan kepada pengguna aplikasi OVO di UNTAR. Hasil penelitian ini menunjukan bahwa Financial Knowledge dan Financial Confidence berpengaruh signifikan terhadap Financial Behavior sedangkan Financial Satisfaction tidak berpengaruh terhadap Financial Behavior.
Peran Social Media terhadap Organizational Performance dan Entrepreneurial Orientation pada Bisnis Coffee Shop di Jakarta Barat
Authors: Margasho Polando Polozona , Susanto Eko Harry
Published: January 2021

The purpose of this study is to examine the role of social media on organizational performance and entrepreneurial orientation in the coffee shop business in West Jakarta. The sample was chosen using non-probability sampling totaling 50 respondents who are coffee shop business owners who use social media in West Jakarta. Data processing techniques using the SmartPLS 3 program. The results of this study indicate that 1) social media significantly contributes to organizational performance. 2) social media significantly contributes to entrepreneurial orientation. Tujuan dari penelitian ini adalah untuk menguji peran media sosial terhadap kinerja organisasi dan orientasi kewirausahaan pada bisnis kedai kopi di Jakarta Barat. Sampel dipilih menggunakan non-probability sampling berjumlah 50 responden yang merupakan pemilik bisnis kedai kopi yang menggunakan media sosial di Jakarta Barat. Teknik pengolahan data menggunakan program SmartPLS 3. Hasil penelitian ini menunjukkan bahwa 1) media sosial berperan terhadap kinerja organisasi. 2) media sosial berperan terhadap orientasi kewirausahaan.
Wizerunek miast konurbacji górnośląskiej – wyzwanie przełamywania stereotypów
Authors: Żemła Michał , Szubert Mariusz
Published: January 2021

W artykule zaprezentowano postrzeganie miast konurbacji górnośląskiej przez studentów Turystyki i Rekreacji Uniwersytetu Pedagogicznego w Krakowie. Katowice oraz pozostałe miasta konurbacji zmieniają swoje oblicze odchodząc od rozwiniętych funkcji przemysłowych w stronę funkcji metropolitalnych, w tym turystycznej. Wyniki badań pokazują jednak, że te faktyczne zmiany, pomimo wysiłku promocyjnego poszczególnych urzędów miast i urzędu marszałkowskiego, nie przekładają się na poprawę wizerunku tych miast i zmianę stereotypowego ich postrzegania. Wyjątkiem są Katowice. Jest to miasto najbardziej znane respondentom spośród innych miast konurbacji. Dostrzegają w nim atrakcje turystyczne, krajoznawcze oraz możliwość atrakcyjnego spędzania czasu wolnego. Niewątpliwy wpływ na wizerunek tego miasta ma Katowicka Strefa Kultury o ponadregionalnym, a w wielu aspektach międzynarodowym oddziaływaniem.
Rola turystyki kulturowej w poznaniu dziedzictwa społeczności żydowskiej w Krakowie
Authors: Bodurka Marzena
Published: January 2021

Głównym celem artykułu jest przedstawienie turystyki skupiającej się w kierunku poznania dziedzictwa kulturowego społeczności żydowskiej na terenie Krakowa. W artykule przedstawiono oraz przedyskutowano kilka ważnych kwestii. Rozważaniom poddano znaczenie turystyki kulturowej, odgrywającej coraz większą rolę w sektorze turystycznym miasta. Wskazano także pozostałości kultury żydowskiej na terenie krakowskiej dzielnicy Kazimierz, cieszące się dużym zainteresowaniem wśród odwiedzających. Znaczny wzrost przyjazdów społeczeństw żydowskich do Polski, w tym Krakowa można zaobserwować od początku lat 90 ubiegłego wieku, co zostało spowodowane korzystnymi zmianami politycznymi oraz chęcią poznania polskiej historii. W artykule szczególna uwagę poświęcono charakterystyce kultury żydowskiej oraz przyjazdom społeczności żydowskich do miasta Krakowa. Analiza owego rynku turystycznego była możliwa dzięki przeprowadzonym badaniom wykonanym od grudnia 2017 roku do maja 2018r. Badania pozwoliły również na wyselekcjonowanie kilku istotnych, z punktu widzenia kultury żydowskiej, czynników rozstrzygających decyzje gości o pobycie w danym obiekcie hotelowym. Artykułu może stać się motywacją do kolejnych rozważań obejmujących wskazaną problematykę.
Kultura łemkowska w skrócie – dla nauczycieli geografii
Authors: Barnat Anna
Published: January 2021

Niniejsze opracowanie zawiera najważniejsze informacje o mniejszości łemkowskiej, zarówno o opisywanej grupie, jak i o historycznym regionie, w którym żyją. Tekst ma posłużyć głównie zainteresowanym nauczycielom geografii, by mogli poszerzać i uzupełniać własną wiedzę. Autorka ma również nadzieję, że opracowanie zainspiruje pedagogów do podejmowania tematu Łemków w dyskusjach podczas prowadzonych lekcji oraz wybierania destynacji ćwiczeń terenowych z zakresu geografii społecznej. Artykuł odpowiada na pytania: Kim są Łemkowie? Gdzie współcześnie mieszkają w Polsce i na świecie? Czym charakteryzuje się ich kultura? Jaką wyznają religię? Jakim językiem mówią? oraz Którzy Łemkowie są powszechnie znani w kulturze oraz w nauce polskiej i światowej?
Geografia w liceum ogólnokształcącym – wyzwania a rzeczywistość
Authors: Osuch Wiktor
Published: January 2021

W związku z podjętą w ostatnich latach gruntowną reformą systemu edukacji w Polsce zwrócono uwagę na pierwsze efekty „nowego kształcenia geograficznego” w szkole ponadpodstawowej, a szczególnie w liceum. W roku szkolnym 2019/2020 w pierwszych klasach liceum występuje kształcenie podwójnego rocznika uczniów, którzy realizują zarówno wersję dotychczasowej podstawy programowej (po gimnazjum), jak i nowego kształcenia, według „nowej podstawy programowej” po szkole podstawowej. Sytuacja ta, oprócz organizacyjnego zamieszania spodziewanego wcześniej przez dyrekcje i nauczycieli liceów, budzi sporo kontrowersji w zakresie kształtowania kompetencji przedmiotowych uczniów w klasach pierwszych. Uczniowie ci przyszli do „nowego liceum ogólnokształcącego” bez pełnego przygotowania geograficznego, ograniczonego do dwóch klas szkoły podstawowej – klas VII i VIII. Natomiast uczniowie realizujący podstawę programową po gimnazjum, mają inny program realizacji treści i kończą obowiązkową edukację geograficzną po pierwszej klasie. W opracowaniu dokonano niełatwej próby oszacowania efektów kształcenia geograficznego dwóch roczników liceum, realizujących różne podstawy programowe. Zadanie to jest skomplikowane, bowiem te dwa roczniki w poziomie jednej klasy licealnej realizują inne podstawy programowe i różne programy nauczania. Uznano, że warto dokonać analizy możliwości wykształcenia kompetencji geograficznych wśród uczniów liceum i poddać je swoistej ocenie oraz refleksji, co przyjęto za główny cel niniejszego opracowania.
Panorama demograficzna meksykańskiej części Półwyspu Jukatan w latach 1990-2010
Authors: Winiarczyk-Raźniak Anna
Published: January 2021

Półwysep Jukatan, w granicach Meksyku podzielony administracyjnie na trzy stany: Campeche, Quintana Roo oraz Yucatán, charakteryzuje się specyficznymi cechami przemian demograficznych. Zamieszkany jest przez wieloetniczne, wielokulturowe oraz wielojęzyczne społeczeństwo. Przeszłość historyczna tego obszaru, od czasów prekolumbijskich do współczesności, w dużym stopniu zaważyła na procesach i tendencjach, jakie kształtowały obraz demograficzny tego regionu. Celem opracowania jest analiza demograficznych i społecznych przemian, jakie zachodzą na terenie badanych trzech meksykańskich stanów, na przełomie XX i XXI w. Badanie dotyczy zmian liczby ludności, poziomu urbanizacji, przyrostu naturalnego, migracji oraz struktur płci i wieku w latach 1990 – 2010. Analizy statystyczne oparto o dane zaczerpnięte z kolejnych trzech spisów ludności Meksyku: w 1990, 2000 i 2010 r. Na badanym obszarze zaobserwowano wzrost gęstości zaludnienia, szczególnie w gminach na terenie których zlokalizowane są duże miasta. W badaniu zwraca uwagę również wzrost poziomu urbanizacji, przy jednoczesnym występowaniu gmin pozostających bez ośrodków miejskich. Najbardziej zauważalne kontrasty demograficzne na półwyspie można zaobserwować między regionami wiejskimi a miejskimi. W badanym okresie zauważono z kolei wyraźny spadek przyrostu naturalnego, w szczególności w obszarach wysoko zurbanizowanych. Zmiany modelu prokreacji oraz rodziny widoczne są również na przykładzie piramid płci i wieku. Wskazują one na zmiany w liczbie urodzeń oraz na odejście od cech charakterystycznych dla społeczeństwa słabo rozwiniętego. Bardzo ważnym bodźcem, wpływającym na przemiany demograficzne na badanym terenie są migracje, skupiające ludność przede wszystkim na obszarach dużych miast, oraz w gminach je otaczających.
Teacher's professional standard: comparative analysis of professional activity evaluation in foreign countries
Authors: Komarova Tatiana
Published: January 2021

Teacher's professional standard in the Russian Federation sets new requirements for a teacher, both in terms of content and results of educational activities. In this regard, the topical issue of modern research becomes the international experience study in standardizing the evaluation of teacher's professional activity and analysis when transferring and implementing into Russian practice. The article presents a comparative analysis of the legal bases, conditions and evaluation tools of teacher's professional activity in the research countries - England, Australia, Singapore and Hong Kong. As a result of the analysis, structural elements, basic procedures and tools, as well as features of the implementation of evaluation systems in foreign countries are identified. The prevailing feature of teacher evaluation in all countries is the forming evaluation, which makes it possible to analyze professional activities, diagnose professional difficulties and find ways to fill in the teacher's deficit characteristics.
The educational process during the period of distance education using innovational technologies
Authors: Stadnikova Valentina , Papiyan Tigran
Published: January 2021

The article declares the main conditions of existing distance education , which is very actual all over the world within the period of COVID-19 pandemiс. The authors give not only detailed evaluation of the existing methods but offer as well a number of innovational technologies and methods of working with them in order to improve the whole educational process.
Formation of the professional orientation of students of secondary medical educational institutions
Authors: Ursilova Leyla
Published: January 2021

The article considers the process of formation of professional orientation of students of secondary medical schools. It is concluded that due to the formation and development of specific professionally significant qualities, it is possible to achieve optimal professional orientation and high labor efficiency.
Determinan Stunting pada Anak Balita di Desa Jambearum Kecamatan Sumberjambe Kabupaten Jember
Authors: Aiman Dida Tadmar , Rohmawati Ninna , Sulistyani Sulistyani
Published: January 2021

Stunting is a condition when a toddler fails to grow at his age due to malnutrition from the fetus until the baby is born and usually can be seen at the age of two years. According to Dinas Kesehatan Jawa Timur, Jember is included on 11 districts in Indonesia which are focused on handling stunting. The district with the highest stunting rate in Jember Regency in 2018 is Sumberjambe District. In 2016, the prevalence of stunting in Sumberjambe District was 38.38%, in 2017 was 38.14% and in 2018 was 32.32%. This study aims to look for determinants of the incidence of stunting in toddlers aged 12-59 months in Jambearum Village, Sumberjambe District. This study uses a cross sectional research design. The methode of taking sample uses simple random sampling. Data analysis used the chi square statistical test. The bivariate test showed that there was a significant relationship between food intake, consist of energy (p=0,026), zinc (p=0,045) and calcium (p=0,011) with the incidence of stunting in children under five in Jambearum Village, Sumberjambe Subdistrict, Jember Regency and there was no significant relationship between food intake (protein, iron and phosphorus) , infectious diseases, baby low birth weight status and genetic with the incidence of stunting in toddlers in Jambearum Village, Sumberjambe Subdistrict, Jember Regency.
Design Formulir Informed Consent Unit Layanan Kesehatan Jiwa Puskesmas Candipuro
Authors: Ferly Ferly , Nurmawati Ida
Published: January 2021

Pencatatan data tentang tindakan yang dilakukan tenaga medis terhadap pasien sangat penting untuk didokumentasikan dalam formulir rekam medis. Sehingga formulir perlu didesain sedemikian rupa guna memenuhi kebutuhan pengguna. Berdasarkan survei pendahuluan di Puskesmas Candipuro formulir persetujuan tindakan kedokteran pasien gangguan jiwa masih menggunakan formulir rawat jalan biasa, tidak mencerminkan formulir informed consent pasien gangguan jiwa. Tujuan penelitian ini adalah untuk mendesain formulir informed consent pasien gangguan jiwa pada Unit Layanan Kesehatan Jiwa Puskesmas Candipuro. Metode yang digunakan kualitatif dengan teknik pengumpulan data observasi, wawancara, dan brainstorming, subjek penelitian yaitu 1 petugas rekam medis, 2 perawat pasien jiwa, dokter yang menangani pasien gangguan jiwa, dan kepala puskesmas. Analisis data dalam penelitian ini menggunakan analisis data reduction, data display, dan conclusions. Hasil penelitian ini adalah rancangan desain formulir informed consent pasien gangguan jiwa yang sesuai kebutuhan pengguna berdasarkan aspek fisik menggunakan kertas HVS F4 dengan berat 70 gram, aspek anatomi menyesuaikan standar desain formulir, dan aspek isi formulir menyesuaikan kebutuhan pengguna dengan mencantumkan data administratif dan data klinis yang terdiri dari diagnosa dan dasar penegakannya, tindakan medis yang terdiri dari indikasi, tata cara, tujuan, dan risikonya, serta informasi lain yang dibutuhkan dalam informed consent. Desain formulir informed consent pasien gangguan jiwa yang baru dapat diterapkan di Unit Layanan Kesehatan Jiwa Puskesmas Candipuro untuk menunjang kelengkapan informasi rekam medis pasien gangguan jiwa dan untuk menghindari malpraktik.
Pola Asuh Ibu dalam Kebersihan Organ Reproduksi selama Menstruasi pada Remaja Tunagrahita
Authors: Nafikadini Iken , Paramarta Driya
Published: January 2021

Mentally retarded children are children who have limitations in intellectual abilities. The classification of mental retardation based on intellectual classification is divided into three classes, namely debil/moron, moderate, and idiot. Mentally retarded children will step into adolescence which will be marked by physical changes but not in line with their thinking abilities. Reproductive health problems arise in children with mental retardation, especially during menstruation. Personal hygiene during menstruation should be noticed by mentally disabled children that have mental retardation. The role of mothers in caring is very helpful in personal hygiene during menstruation so that children with mental disabilities can be more independent and do not depend on others. The purpose of this study is to explore the mother education system  toward personal hygiene of reproductive organs during menstruation in mentally retarded adolescents. The determination of informants in this study by using purposive technique. Researchers collected data using in-depth interviews, and triangulation of sources. The results of this study indicate that all informants provided regulatory aspects through communicated oral regulations such as by reminding and giving examples. Most mothers have given punishment through verbal, such as yelling, and through physical punishment such as hitting. All mothers have given appreciation through praise in subtle ways, smiles, seduction when the child can behave following what has been taught. All  mothers have provided an aspect of consistency by reminding their children all the time, communicating with the school’s teacher, additionally providing examples and direct practice in front of the children.
Development Quadcopter Flight Controller Architecture Based on a Single-Board Computer Raspberry Pi
Authors: Lipoviy Dmitriy A. , Maltsev Aleksandr S.
Published: January 2021

This work is devoted to development of a modular flight controller architecture for a quadcopter. The hardware part of the controller is a single-Board raspberry Pi computer, for developing the software part Robot Operating System (ROS) framework was used. The paper describes the developed architecture, control algorithms, results of flight experiments in the Gazebo physical simulator.
Repeatability of the Data from Social Interactions Experiments Depending on Personal Characteristics
Authors: Merkulova Ekaterina A. , Kozulin Igor A. , Savostiyanov Alexandr N. , Bocharov Andrey B. , Knyazev Gennady K.
Published: January 2021

The presented study examines the problem of the reliability of experimental data, which is acute in the field of psychology and neurophysiology. The problem is related to the fact that the participation of a human subject in one experiment from a series of experiments can affect his behavior in the next experiment, cause undesirable distortions in the
obtained experimental data and, as a result, lead to false conclusions. It is shown that the test-retest method gives the most qualitative assessment of the reliability and this estimate is in good agreement with the results of calculating the reliability by the method of interclass correlation coefficients. Data obtained in a neurophysiological experiment on social interaction is used as the initial data.
Enhancement of Tryptic Peptide Signals from Tissue Sections using MALDI IMS Post-ionization (MALDI-2)
Authors: McMillen Josiah , Gutierrez Danielle B. , Judd Audra M. , Spraggins Jeffrey , Caprioli Richard M.
Published: January 2021

Matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) allows for highly multiplexed, unlabeled mapping of analytes from tissue sections. However, further work is needed to improve sensitivity and depth of coverage for protein and peptide IMS. Laser-based post-ionization MALDI-2 has been shown to increase sensitivity for several molecular classes but thus far this has not been reported for peptides. Here, we demonstrate signal enhancement of proteolytic peptides from thin tissue sections of human kidney by conventional MALDI (termed MALDI-1), and conventional MALDI augmented using a second ionizing laser (termed MALDI-2). Proteins were digested in situ using trypsin prior to IMS analysis. For identification of peptides and proteins, a tissue homogenate was analyzed by LC-MS/MS for bottom-up proteomics and the corresponding proteins identified. These proteins were next fully ‘digested in silico’ to generate a database of theoretical peptides to then match to MALDI IMS datasets. Peptides were tentatively identified by matching the MALDI peak list to the database peptide list employing a 5 ppm error window. This resulted in 314 ± 45 (n=3) peptides and 1 112 ± 84 (n=3) peptides for MALDI-1 and MALDI-2, respectively. Protein identifications were similarly made by linking IMS data to the LC-MS/MS peptide database. With positive protein identifications requiring two or more peptides per protein, 55 ± 13 proteins were identified with MALDI-1 and 205 ± 10 with MALDI-2. These results demonstrate that MALDI-2 provides enhanced sensitivity for the spatial mapping of tryptic peptides and significantly increases the number of proteins identified in IMS experiments.
How to Organize a Photocatalysis Conference Online (on a Budget)
Authors: Micheel Mathias , Hniopek Julian , Hofmeister Elisabeth , Müller Carolin , Putra Miftahussurur Hamidi , Schwiedrzik Ludwig , Wintergerst Pascal
Published: January 2021

Originally planned as an on-site meeting, the inaugural CataLight Young Scientist Symposium (CYSS) took place as a fully online conference in November 2020. Dedicated to various aspects of photocatalysis, namely synthesis, theory, characterization, and application, CYSS aimed to provide a stage for early-career scientists to connect to each other and present their research to peers in the field. While still keeping a traditional on-site conference format including both plenary and poster sessions, several minor and major changes had to be applied to the format to deliver a full experience. In this report, we highlight key steps in the organization of such an online conference, laying a focus on using mostly open source software to minimize costs, and discuss differences to both on-site and other online conference formats.
Scalable nanoprecipitation of niclosamide and in vivo demonstration of long-acting delivery after intramuscular injection
Authors: Hobson James , Savage Alison , Dwyer Andrew , Unsworth Catherine , Arshad Usman , Pertinez Henry , box helen , Tatham Lee , Rajoli Rajith K. R. , Neary Megan , Sharp Joanne , Valentijn Anthony , David Christopher , Curley Paul , Liptrott Neill , Mcdonald Tom , Owen Andrew , Rannard Steve
Published: January 2021

The spread of SARS-CoV-2 across the world requires the formation of a range of interventions that include immunomodulatory or antiviral therapeutics and repurposing of existing drug compounds is an important strategy to rapidly identify possible options. Niclosamide is a cheap and generic drug compound with a proven in vitro ability to inhibit viral replication of SARS-CoV-2; this drug also has known poor oral bioavailability due to very low water solubility. Here, we demonstrate the nanoparticle formulation of niclosamide using a new, cheap and scalable process to enable long-acting injectable administration and show extended circulating drug exposure in vivo over 28 days using a rodent model after depot injection.
Design of an Antioxidant Nitrone Scaffold Based on Plant Pigments
Authors: Pinheiro Amanda Capistrano , Fazzi Rodrigo Boni , Esteves Larissa Cerrato , Machado Caroline Oliveira , Dörr Felipe Augusto , Pinto Ernani , Hattori Yocefu , Sa Jacinto , Da Costa Ferreira Ana Maria , Leite Bastos Erick
Published: January 2021

Nitrones derived from natural antioxidants are emerging as highly specific therapeutics against various human diseases, including stroke, neurodegenerative pathologies, and cancer. However, the development of useful pseudo-natural nitrones requires the judicious choice of a secondary metabolite as the precursor. Betalains are nitrogen-containing natural pigments that exhibit marked antioxidant capacity and pharmacological properties and, hence, are ideal candidates for designing multifunctional nitrones. In this work, we describe the semisynthesis and properties of a biocompatible, antioxidant betalain-nitrone called OxiBeet. This bio-based compound is a better radical scavenger than ascorbic acid, gallic acid, and most non-phenolic antioxidants and undergoes concerted proton-coupled electron transfer. The autoxidation of OxiBeet produces a persistent nitroxide radical, which, herein, is studied via electron paramagnetic resonance spectroscopy. In addition, femtosecond transient absorption spectroscopy reveals that excited state formation is not required for the oxidation of OxiBeet. The results are compared with those obtained using betanin, a natural betalain, and pBeet, the imine analog of OxiBeet. The findings of this study will enable the development of antioxidant nitrones based on the novel N-oxide 1,7-diazaheptamethinium scaffold and betalain dyes with enhanced hydrolytic stability in aqueous alkaline media.
Ligand Rearrangement Leads to Tetrahydrothiophene-Functionalized N,S-Heterocyclic Carbene Palladium(II) Complexes
Authors: Romine Andrew , Demer Matthew , Gembicky Milan , Rheingold Arnold L. , Engle Keary
Published: January 2021

Tetrahydrothiophene-functionalized N,S-heterocyclic carbene palladium(II) complexes are synthesized through an unexpected rearrangement that proceeds with palladium(II) trifluoroacetate and not with palladium(II) acetate, palladium(II) bromide, or palladium(II) chloride. A series of these complexes were isolated and characterized by X-ray crystallography. The mechanism of formation of these [3.2.1]-palladabicycles was explored, and the catalytic capabilities of these complexes were demonstrated in representative C–C coupling reactions.
Preventing Agglomeration of CuO-Based Oxygen Carriers for Chemical Looping Applications
Authors: Imtiaz Qasim , Armutlulu Andac , Donat Felix , Naeem Muhammad Awais , Müller Christoph
Published: January 2021

Chemical looping combustion (CLC) is a promising alternative to the conventional combustion-based, fossil fuel conversion processes. In CLC, a solid oxygen carrier is used to transfer oxygen from air to a carbonaceous fuel. This indirect combustion route allows for effective CO2 capture since a sequestrable stream of CO2 is inherently produced without any need for energy-intensive CO2 separation. From a thermodynamic point of view, CuO is arguably one of the most promising oxygen carrier candidates for CLC. However, the main challenge associated with the use of CuO for CLC is its structural instability at the typical operating temperatures of chemical looping processes, leading to severe thermal sintering and agglomeration. To minimize irreversible microstructural changes during CLC operation, CuO is commonly stabilized by a high Tammann temperature ceramic, e.g., Al2O3, MgAl2O4, etc. However, it has been observed that a high Tammann temperature support does not always provide a high resistance to agglomeration. This work aims at identifying descriptors that can be used to characterize accurately the agglomeration tendency of CuO-based oxygen carriers. CuO-based oxygen carriers supported on different metal oxides were synthesized using a Pechini method. The cyclic redox stability and agglomeration tendency of the synthesized materials was evaluated using both a thermo-gravimetric analyser and a lab-scale fluidized bed reactor at 900 °C using 10 vol. % H2 in N2 as the fuel and air for re-oxidation. In order to study the diffusion of Cu(O) during redox reactions, well-defined model surfaces comprising thin films of Cu/CuO and two different supports, viz. ZrO2 or MgO, were prepared via magnetron sputtering. Energy dispersive X-ray (EDX) spectroscopy on focused ion beam (FIB)-cut cross-sections of the thin films revealed that Cu atoms have a tendency to diffuse outward through most of the films of the support material under redox conditions. The support that inhibits the outward movement of Cu(O), i.e. avoiding the presence of low melting Cu on the oxygen carrier surface, is found to provide the highest agglomeration resistance. The support MgO was found to possesses such diffusion characteristics.
Adsorbed Xenon Propellant Storage: Are Nanoporous Materials Worth the Weight?
Authors: Huynh Melanie T. , Gantzler Nickolas , Hough Samuel , Roundy David , Thallapally Praveen K. , Simon Cory M.
Published: January 2021

Xenon is used as a propellant for spacecraft. Conventionally, xenon is compressed to high pressures (75-300 bar) for bulk storage onboard the spacecraft. An adsorbed xenon storage system based on nanoporous materials (NPMs) could, potentially, (i) reduce the storage pressures, (ii) allow for thinner-walled and lighter pressure vessels, and (iii) if the NPM itself is sufficiently light, reduce the overall mass of the storage system and thus of the payload of the rocket launch.

To investigate, we develop a simple mathematical model of an adsorbed xenon storage system by coupling a mechanical model for the pressure vessel and a thermodynamic model for the density of xenon adsorbed in the NPM. From the model, we derive the optimal storage pressure, tailored to each NPM, with the objective of minimizing the mass of the storage materials (walls of the pressure vessel + NPM) required to store the xenon. The model enables us to: (i) rank NPMs for adsorbed xenon propellant storage, (ii) compare adsorbed storage to the baseline of bulk storage, and (iii) understand what properties of NPMs are desirable for adsorbed xenon propellant storage.

We use the model to evaluate several NPMs, mostly metal-organic frameworks (MOFs), for adsorbed xenon propellant storage at room temperature, using experimental xenon adsorption data as input. We find Ni-MOF-74 and MOF-505 outperform the traditional adsorbent, activated carbon. However, we find each optimized adsorbed xenon storage system is heavier than the optimized bulk storage system, owing dominantly to the large mass of the NPM itself. Our model suggests that, for a NPM to provide a lighter adsorbed xenon storage system compared to bulk storage, the saturation loading of xenon in the adsorbent must exceed ca. 94 mmol Xe/g adsorbent.
Computational Prediction of Metabolites of Tobacco-Specific Nitrosamines by CYP2A13
Authors: Byler Kendall , Makena Patrudu , Prasad G L , Baudry Jerome
Published: January 2021

A computational approach for the prediction of tobacco-specific nitrosamine (TSNA) metabolites by cytochrome P450s (CYPs) has been developed that currently predicts all of the known CYP2A13 metabolites of nicotine-derived nitrosamine ketone (NNK), N-nitrosonornicotine (NNN), and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) resulting from hydroxylations and heteroatom oxidations reported in metabolomics literature. This computational approach integrates 1) machine learning models trained on quantum-mechanically-derived molecular surface properties for a set of CYP substrates with known metabolites to identify sites of metabolism across CYP isoforms and 2) validation of machine learning predictions using ensemble docking of the TSNA parent molecules into CYP2A13’s binding site to identify the most likely TSNA reactive atoms. This method is generalizable to any CYP isoform for which there is structural information, opening the door to the prediction of P450-based metabolite prediction, as well as prediction and rationalization of metabolomics data.
Deeper Protein Identification by Using FAIMS in Top-down Proteomics
Authors: Gerbasi Robert , Melani Rafael D. , Abbatiello Susan E. , Belford Michael W. , Huguet Romain , McGee John P. , Dayhoff Dawson , Thomas Paul M. , Kelleher Neil. L
Published: January 2021

Field Asymmetric Ion Mobility Spectrometry (FAIMS), when used in proteomics studies, provides superior selectivity, and enables more proteins to be identified by providing additional gas phase separation. Here, we tested the performance of cylindrical FAIMS for the identification and characterization of proteoforms by top-down mass spectrometry of heterogeneous protein mixtures. Combining FAIMS with chromatographic separation resulted in a 62% increase in protein identifications and an 8% increase in proteoform identifications as compared to samples analyzed without FAIMS. This increase was attributable, in part, to improved signal-to-noise for proteoforms with similar retention times. Additionally, our results show that the optimal compensation voltage of any given proteoform was correlated with the molecular weight of the analyte. Collectively these results suggest that the addition of FAIMS can enhance top-down proteomics in both discovery and targeted applications.
A novel canis lupus familiaris reference genome improves variant resolution for use in breed-specific GWAS
Authors: Player Robert A , Forsyth Ellen R , Verratti Kathleen J , Mohr David W , Scott Alan F , Bradburne Christopher E
Published: January 2021

Reference genome fidelity is critically important for genome wide association studies, yet most vary widely from the study population. A typical whole genome sequencing approach implies short-read technologies resulting in fragmented assemblies with regions of ambiguity. Further information is lost by economic necessity when genotyping populations, as lower resolution technologies such as genotyping arrays are commonly used. Here, we present a phased reference genome for Canis lupus familiaris using high molecular weight DNA-sequencing technologies. We tested wet laboratory and bioinformatic approaches to demonstrate a minimum workflow to generate the 2.4 gigabase genome for a Labrador Retriever. The de novo assembly required eight Oxford Nanopore R9.4 flowcells (∼23X depth) and running a 10X Genomics library on the equivalent of one lane of an Illumina NovaSeq S1 flowcell (∼88X depth), bringing the cost of generating a nearly complete reference genome to less than $10K (USD). Mapping of short-read data from 10 Labrador Retrievers against this reference resulted in 1% more aligned reads versus the current reference (CanFam3.1, P < 0.001), and a 15% reduction of variant calls, increasing the chance of identifying true, low-effect size variants in a genome-wide association studies. We believe that by incorporating the cost to produce a full genome assembly into any large-scale genotyping project, an investigator can improve study power, decrease costs, and optimize the overall scientific value of their study.
INTERDISCIPLINARIDADE: CARACTERÍSTICAS E POSSIBILIDADES PARA O ENSINO DE FÍSICA E QUÍMICA
Authors: Cantanhede Severina Coelho da Silva , Silva André Flávio Gonçalves , Silva Francisco Hermes Santos da , Silva Maria de Fátima Vilhena da
Published: January 2021

Este trabalho busca elencar o quantitativo de artigos publicados em alguns periódicos nacionais que tratem a Física e a Química de maneira interdisciplinar. Para delimitar o espaço amostral, limitamo-nos a fazer apontamentos considerando somente os trabalhos com o enfoque no Ensino Básico. A busca foi realizada a partir da palavra interdisciplinar em periódicos da área de Ensino de Ciências com Qualis/CAPES A1, A2, B1 e B2, entre os anos de 2009 e 2019. O foco foram os artigos que abordavam a Física e Química de maneira interdisciplinar. A discussão tem como fundamento os documentos oficiais de educação a respeito da interdisciplinaridade, como também as contribuições provenientes da leitura dos textos selecionados. Como resultado, pudemos verificar que a maioria dos trabalhos que tratam da Física e Química de maneira interdisciplinar está concentrada no Ensino Superior, sendo que no segundo quinquênio foi possível verificar um aumento substancial na quantidade de trabalhos publicados nos periódicos analisados. Também foi possível verificar que os periódicos que contribuem com cerca de 80% de toda publicação coletada nesta pesquisa são: Revista Brasileira de Ensino de Ciências e Tecnologia, Revista Areté/Revista Amazônica de Ensino de Ciências e Revista Brasileira de Ensino de Física, sendo esta última, responsável por agrupar metade dos artigos selecionados para esta análise.
CONHECIMENTO GEOMÉTRICO NAS PERSPECTIVAS DA PEDAGOGIA DA ALTERNÂNCIA E ETNOMATEMÁTICA NUMA ESCOLA FAMÍLIA AGRÍCOLA
Authors: Vieira Vanessa da Luz , Rosa Milton
Published: January 2021

Este artigo é um recorte de uma pesquisa qualitativa conduzida em uma Escola Família Agrícola, localizada na Zona da Mata, Minas Gerais. O seu principal objetivo foi compreender como 24 alunos dessa escola lidam com os conceitos geométricos quando estão em ambientes distintos: escola/família/comunidade. Essa pesquisa foi conduzida de acordo com as perspectivas da Pedagogia da Alternância e da Etnomatemática, visando responder a questão de investigação: Quais são as contribuições que a etnomatemática pode trazer para a construção do conhecimento geométrico de alunos do primeiro ano do ensino médio em uma escola família agrícola na perspectiva da pedagogia da alternância? Essa pesquisa fundamenta-se nas bases teóricas da Pedagogia da Alternância, da Educação do Campo, dos Fundos de Conhecimento e da Etnomatemática. Os dados foram coletados por meio de dois questionários: um inicial e um final; anotações no diário de campo, três blocos de atividades, um grupo focal e, também, pela utilização de três instrumentos da alternância: o Plano de Estudo, o Caderno da Realidade e a Colocação em Comum. Os dados coletados foram analisados conforme os pressupostos adaptados da Teoria Fundamentada nos Dados. Os resultados dessa pesquisa mostram que uma contribuição importante da Etnomatemática para o desenvolvimento de conteúdos geométricos nessa escola, na perspectiva da Pedagogia da Alternância, foi a valorização sociocultural da produção de conhecimentos geométricos desenvolvidos por esses participantes, que compartilharam as práticas locais em sala de aula conectando-as aos conteúdos geométricos escolares.
La inmunohematología y los estudios de paternidad utilizando grupos sanguineos
Authors: Cañizares Claudio
Published: January 2021

Today it is a world-wide practice the use of blood groups for the exclusion of parentage. In our country this practice has been introduced by the Court of Justice.

The study has to be conducted by a reliable persone, with excelent training in immunohematology and Genetics.

Three systems of blood groups, ABO-Rh-MN, are sufficient to give a great probability (near 55%) of exclusion of falsely accused paternity. The use of other blood systems do not increase neither the accuracy nor the scape of the screening in a significant manner.

Good care has to be taken to prove that the set of antisera are in good condition.

It is important that all the persons involved should be present, with the legal adviser the moment the blood samples are drawn. In this way the possibility of supplantation is abolished.

In our experience we have confirmed 3 exclusions out of 10 cases sent for study.
The intravarietal relationship among different accessions of Dolichos biflorus was checked based on protein profiling using SDS-PAGE.
Authors:   Plant Biotechnology Laboratory, Department of Botany, Dayalbagh Educational Institute (Deemed University) Dayalbagh, Agra, India
Published: January 2021

In this study, the phylogenetic relationship within the selected Eleven Indian (Dolichos biflorus (horse gram) varieties was analyzed for total soluble seed protein. Twenty-five bands were documented through SDS PAGE based on 100 seed weight of each variety and were studied for genetic diversity. Jaccard’s similarity matrix was acquired and used in UPGMA cluster analysis based on the polymorphism generated by the presence (1) or absence (0) of protein bands. Thus, the dendrogram showed four major groups that corre-spond to an earlier study on polymorphisms of 11 accessions of Indian Dolichos. Signifi-cant correspondence between the clustering pattern and the pedigree was observed; thus, a high genetic diversity could be kept within the Dolichos varieties. A similarity matrix among the targeted genotypes and phylogenetic analysis is considered a unique feature in the present work. Therefore, the current investigation was carried out to analyse Protein diversity of unexplored Dolichos genotypes at the molecular level, construct a dendro-gram based on similarity band matrix and generate efficiency in genetic divergence analy-sis among Dolichos. This study underlines the importance of using genetic diversity based in the Dolichos breeding program.
Isolated Aortitis with multiple Aortic aneurysms and widespread venous, arterial and intracardiac thrombosis: A challenging Vascular Behcet’s Disease case management
Authors:   Rheumatology section, Department of Medicine, Hamad General Hospital, Doha, Qatar, P.O.Box 3050
Published: January 2021

In 1937, Hulusi Behcet’s brought to our attention the existence of a disease characterized by recurrent oral aphthae and any of several systemic manifestations including genital aphthae, ocular disease, skin lesions, gastrointestinal involvement, neurologic disease, vascular disease, or arthritis [1-3]. He became the first physician to describe this and the disease was henceforth named after his name. The aetiology of this disease remains unclear however it has been noticed that Behcet’s syndrome is remarkable for its systemic vasculitides which include its ability to involve blood vessels of all sizes (small, medium, and large) on both the arterial and venous sides of the circulation with occlusive nature [4]. This makes Vasculitis the major cause of the clinical manifestations of the disease with the involvement of almost any organ. We herein report an unusual case of a thirty-year-old Syrian man with no past medical illnesses. On presentation, he suffered from a sudden onset of shortness of breath and a history of hoarseness of voice for less than a week, and drastic weight loss of about thirty kgs within a month. Imaging confirmed the presence of pulmonary embolism, bilateral deep venous thrombosis, intracardiac thrombosis, popliteal artery thrombosis with thoracic, and abdominal aortic aneurysms. This case highlights the importance of having a high suspicion of the possibility of Behcet’s disease when multiple thrombi and aneurysms manifest in a patient on the silk root country. Thereby, stressing the importance of familiarizing ourselves with such unusual presentations of Behcet’s disease and the course of this unusual presentation with some learning points with a good literature review included below.
O ESTUDO DO LUGAR A PARTIR DA PRODUÇÃO DE DESENHOS NA GEOGRAFIA ESCOLAR
Authors: Dantas Thiago Calheiros , Dos Santos Maria Francineila Pinheiro
Published: January 2021

Discute-se neste artigo as percepções dos professores e licenciandos em Geografia acerca do conceito de lugar e de como este vem sendo trabalhado na Geografia Escolar. A opção por esta temática surgiu a partir da realização da oficina Múltiplas Linguagens no Ensino de Geografia, na qual foram analisados diferentes recursos didáticos para auxiliar a prática docente, dentre eles o desenho, visto enquanto instrumento metodológico importante na construção do conceito de lugar. O lugar neste trabalho é entendido como uma dimensão do espaço vivido que é dialeticamente construído pela sociedade, onde percebemos a dinâmica do lugar-mundo. A análise dos desenhos produzidos permite concluir que os docentes representam relações presentes no seu cotidiano, notadamente através da ação verticalizada de alguma empresa ao ocupar um espaço e ocasionar de certo modo a retirada dos mais pobres, apontando criticas relacionadas a desigualdade social, e denotando o sentimento de pertencimento ao lugar em que vivem.
O DESENHO COMO RECURSO DIDÁTICO NO ENSINO DE GEOGRAFIA
Authors: Dantas Thiago Calheiros , Santos Maria Francineila Pinheiro dos , Silva Ana Paula Lopes da
Published: January 2021

O artigo tem como objetivo discutir os desenhos enquanto recurso didático no ensino de Geografia. Como procedimentos metodológicos utilizou-se de desenhos e justificativas figurativas dos alunos do 6º ano do ensino fundamental de uma escola pública da cidade de Pilar/Alagoas para viabilizar a análise. As representações dos alunos foram analisadas tanto pela sua forma, quanto pelo conteúdo. A análise da forma (desenho) e conteúdo (justificativas) mostra o entendimento que o alunado tem acerca das relações que possuem com o mundo no lugar (es), as especificidades do(s) lugar (es), e os sentimentos que as pessoas desenvolvem neste(s) espaço(s) e com o outro. Os resultado deste estudo demonstra que os alunos trouxeram fortemente nos desenhos, as relações com o seu cotidiano, destacando a influência da mídia orientando suas concepções, e os sentimentos de pertencimento em relação a rua onde residem.