bluuebunny/crossref_metadata_2025 huggingface dataset:
ADDRESSING PRE-SERVICE TEACHERS’ MISCONCEPTIONS AND PROMOTING CONCEPTUAL UNDERSTANDING THROUGH THE CONCEPTUAL CHANGE MODEL
Authors: Addido Johannes , Burrows Andrea C. , Slater Timothy F.
Published: September 2022

Teaching science concepts for conceptual understanding has its challenges. Bringing about conceptual change in the science classroom can be difficult because most concepts are complicated and often counter-intuitive in the teaching and learning of science concepts. A review of the literature indicates that the conceptual change model, CCM can be an effective teaching technique in addressing misconceptions and improving conceptual understanding when it comes to science instruction. The aim of this research was to find out the effect of the conceptual change model on pre-service teachers’ conceptual understanding regarding the topic of forces and motion. Using data from tests and questionnaires, the research questions were answered by quantitatively analyzing the collected data. The analysis revealed that there is a statistically significant correlation between the conceptual change model and the conceptual understanding of the pre-service teacher participants. Overall, the results provide evidence in support of the effectiveness of the conceptual change model, CCM in addressing misconceptions and promoting conceptual understanding of forces and motion among the pre-service teacher participants that volunteered for this research. The results also indicate that the CCM is a teaching model which must be considered by science educators and teachers as they seek to address issues related to misconceptions and conceptual understanding in the teaching of science topics. Keywords: conceptual change, conceptual change model, conceptual understanding, misconceptions, pre-service teachers, science education
Sinergitas Dinas Pariwisata dan Kebudayaan Kabupaten Rokan Hulu dengan The Caretaker Dalam Pengembangan Objek Wisata Suligi Hill
Authors: Irdayanti Irdayanti , Pangestuti Anggun
Published: September 2022

Penelitian ini bertujuan untuk menjelaskan sinergitas antara Dinas Pariwisata dan Kebudayaan Kabupaten Rokan Hulu dengan The Caretaker sebuah kelompok sadar wisata dalam pengembangan objek wisata Suligi Hill hingga berhasil meraih penghargaan dalam Anugrah Pesona Indonesia (API) tahun 2019, selain itu penelitian ini bertujuan menganalisis hambatan dalam proses pengembangannya. Metode penelitian ini  menggunakan pendekatan kualitatif, dengan teknik pengumpulan data yaitu wawancara, observasi, dan dokumentasi. Untuk menggambarkan sinergitas para aktor dilakukan dengan dua konsep, yaitu komunikasi dan koordinasi dan ditemukan 3 kendala dalam proses pengembangannya yaitu sarana dan prasarana, anggaran serta sumberdaya manusia yang mengelolanya. Selain itu ditemukan juga dalam pengembangan Objek Wisata Suligi Hill belum terdapat kerjasama dengan pihak swasta, sehingga pengembangan Objek Wisata Suligi Hill masih belum maksimal.
IMPLEMENTASI PROGRAM PROGRAM PEMBERDAYAAN MASYARAKAT DALAM PENINGKATAN INFRASTRUKTUR LINGKUNGAN PEMUKIMAN WILAYAH KELURAHAN (PM-PIK) DI DAERAH HINTERLAND KOTA BATAM
Authors: Aristi Novia Dwi , Nurhayati Nurhayati , Solihin Muhammad
Published: September 2022

Pembangunan infrastruktur merupakan bagian dari pembangunan nasional. Pembangunan nasional merupakan usaha yang dilakukan sebagai langkah untuk membangun manusia Indonesia. Masalah infrastruktur yang dihadapi adalah masih kurangnya infrastruktur dasar yang ada di Kota Batam dan masih belum selesainya pusat pemerintahan Kota Batam. Permasalahan infrastruktur ini perlu di tanggulangi untuk mengatasi kesenjangan pembangunan antara wilayah Kabupaten/Kota dalam hal ketersediaan infrastruktur. Sedangkan permasalah yang ada dilapangan penyediaan infrastruktur yang dihadapi adalah belum selesainya pemerataan  Pembangunan Infrastruktur fisik seperti Pembangunan jalan, pembangunan pelantar beton dan batu miring di pantai serta pembukaan akses terhadap daerah terluar atau pulau-pulau yang ada di Kecamatan Bulang. Peneliti merumuskan yaitu Bagaimana Implementasi Pembangunan Infrastruktur di Daerah Hiterland Kota Batam (Studi Penelitian Kecamatan Bulang) Tahun 2017-2018
PENGARUH PELATIHAN, PENGEMBANGAN KARIR, DAN KOMUNIKASI TERHADAP KINERJA KARYAWAN PT. TELEKOMINDO PRIMAKARYA
Authors: Ratnasari Sri Langgeng , Aidah Siti
Published: September 2022

Penelitian ini bertujuan untuk mengetahui pengaruh pelatihan, pengembangan karir, dan komunikasi terhadap kinerja karyawan PT. Telekomindo Primakarya. Pengumpulan data dilakukan melalui penyebaran kuesioner dan dilaksanakan pada 50 karyawan PT. Telekomindo Primakarya. Jenis penelitian ini adalah penelitian deskriptif kuantitatif. Populasi penelitian ini 50 orang dengan sampel 50 orang karyawan, yang dipilih secara keseluruhan sehingga memakai sampling jenuh. Hasil penelitian ini pengujian hipotesis menunjukan variabel Pelatihan nilai t hitung 1,431 t tabel 1,678 dan nilai signifikan 0,164 0,05 yang berarti Ha ditolak dan Ho diterima. Berdasarkan keriteria diatas variabel pelatihan tidak memiliki peran penting dalam mempengaruhi kinerja karyawan. -1,005 t tabel 1,678 dan nilai signifikan 0,324 0,05 yang berarti Ha ditolak Ho diterima. Berdasarkan keriteria diatas variabel pengembangan karir tidak memiliki peran penting dalam mempengaruhi kinerja karyawan. 6,355 t tabel 1,678 dan nilai signifikan 0,000 0,05 yang berarti Ha diterima Ho ditolak. Berdasarkan keriteria diatas variabel komunikasi memiliki peran penting dalam mempengaruhi kinerja karyawan. dan hasil uji F (simultan) dari hasil uji f menunjukan f hitung Hasil uji F memperlihatkan nilai F sebesar     14,564 (F hitung) 2,81 (F tabel) yang berarti Ha diterima dan Ho ditolak. Hal ini berarti bahwa secara bersama-sama variabel pelatihan, pengembangan karir, komunikasi berpengaruh terhadap kinerja karyawanjadi Ha ditolak dan Ho diterima artinya variabel Pelatihan, Pengembangan Karir, Komunikasitidak berpengaruh terhadap variabel kinerja karyawan.
Religious Peace Building; Dalam Masyarakat Multikultural Perspektif Sosiologi Agama
Authors: Sutarto Dendi
Published: September 2022

Dalam masyarakat agama seringkali menampilkan pemahaman yang sempit hinggal melahirkan violence dan war. Agama yang seringkali dihadirkan dalam ruang yang sempit, yang hanya menjadi legitimasi atas berbagai peperangan dan diskriminasi (holy wars) yang merupakan bentuk “jihad” demi membela kebenaran. Pada konteks masyarakat multikultural pemahaman agama seringkali dihadirkan dalam mujud yang kehilangan substansi nilai universal dan toleransi. Seharusnya nilai-nailai agama diwujudkan dalam pola perilaku sosial humanity yang menyejukkan, toleran, dan tidak diskriminasi, sehingga penting religious peace building menjadi paradigm kolektif dalam kehidupan social-religious yang menyatukan unsur-unsur keberagaman dalam masyarakat multikultural. Penelitian ini dalam kerangka analisis sosiologis, dengan menganalisis data-data literatur sebagai data primer. Penelitian ini adalah penelitian literature dengan metode literature review perspektif sosiologis yang berusaha memahami pemahaman dan pemikran ked alam konteks sosialogis tindakan sosial,. Hasil penelitian ini mengungkap bahwa secara sosiologis pemahaman dan pemikiran atas nilai-nilai agama yang bersifat terbuka, toleransi, anti diskriminasi, universal dan menyejukkanperlu dibangun sebagai tindakan tindakan dan nilai-nilai dalam sistem sosio religious  dalam memelihara keberangaman dan perdamaian.
EVALUASI KEBIJAKAN PENGELOLAAN AIR BERSIH SUMBER PRODUKSI SEA WATER REVERSE OSMOSIS DI KECAMATAN BELAKANG PADANG TAHUN 2020
Authors: Zariyanti Zariyanti , Nurhayati Nurhayati , Sutarto Dendi
Published: September 2022

Pada penelitian ini membahas tentang evaluasi kebijakan pengelolaan air bersih sumber produksi Sea Water Reverse Osmosis di Kecamatan Belakang Padang Tahun 2020, penelitian ini mengkaji beberapa permasalahan tentang kebijakan pengelolaan air bersih sumber produksi Sea Water Reverse Osmosis yang dinilai tidak sejalannya harapan dengan kenyataan.Indikator pada penelitian ini menggunakan indikator efektivitas, efisiensi, kecukupan, perataan, responsivitas dan ketepatan. Metode penelitian ini adalah menggunakan metode penelitian kualitatif deskriptif yaitu peneliti melakukan wawancara, observasi dan dokumentasi dalam mengumpulkan data penelitian di lapangan. Hasil dari data yang dikumpulkan oleh peneliti akan diolah dan digambarkan atau dijelaskan secara deskriptif pada penelitian ini.Hasil penelitian ini dapat disimpulkan bahwa ditemukannya permasalahan yang menghambat kebijakan pengelolaan air bersih sumber produksi Sea Water Reverse Osmosis di Kecamatan Belakang Padang Tahun 2020 dilihat dari indikator efektivitas belum memenuhi kuantitas, kontiniunitas dan tarif yang terjangkau, indikator efisiensi masih terdapat kekurangan tenaga pengelola dan biaya produksi yang mahal, indikator kecukupan masih terdapat kekurangan sarana dan prasarana, indikator perataan belum meratanya pembangunan sarana dan prasarana, indikator responsivitas masih ada kritikan terkait tarif dan indikator ketepatan tidak sejalannya sasaran dan tujuan.
Modal Sosial Partai Keadilan Sejahtera Kota Batam dalam Pemilu Legislatif Tahun 2019
Authors: Khasanah Rahma Putri
Published: September 2022

Kajian ini akan membahas mengenai strategi Partai Keadilan Sejahtera di Kota Batam dalam mendapatkan legitimasi masyarakat dalam Pemilu Legislatif. Strategi Politik merupakan seperangkat metode agar dapat memenangkan pertarungan antara berbagai kekuatan politik yang menghendaki kekuasaan. Kemenangan yang diraih bukan sekedar berasal dari eksistensi partainya melainkan juga kemampuan personal seorang aktor politik yang dapat mempengaruhi masyarakat untuk mendukungnya, khususnya pada Dapilnya. Penelitian ini menggunakan metode deskriptif kualitatif dengan wawancara dengan anggota DPRD 2019-2024 Fraksi Partai Keadilan Sejahtera di Kota Batam Muhammad Syafei, menggunakan teori Modal Sosial oleh Bourdieu (1986) yang mengkaji tiga indikatornya yaitu norma sosial, jaringan sosial dan kepercayaan. Hasil penelitian menunjukkan bahwa norma sosial Partai Keadilan Sejahtera mengikuti kearifan lokal daerah, jaringan sosial berkaitan dengan Timses dan pola rekrutmen partai serta legitimasi diperoleh dengan faktor dominan yaitu investasi sosial dan investasi materi.
IMPLEMENTASI PROGRAM KELUARGA BERENCANA DI KOTA BATAM
Authors: Ansanoor Sakiman Hidayat , Pratiwi Diah Ayu , Solihin Muhammad
Published: September 2022

Persoalan kependudukan merupakan persoalan yang sering terjadi di Indonesia, terutama di Kota Batam, tercatat bahwa kota Batam mengalami peningkatan terhadap jumlah penduduk setiap tahunnya. Laju pertumbuhan penduduk di Kota Batam yang cukup tinggi sebesar 2,32% per tahun, berdampak pada angka kelahiran di kota Batam yang mengalami peningkatan dan belum sesuai dengan harapan dalam program Kota Batam. Tujuan penelitian ini adalah mengetahui dan menganalisa bagaimana implementasi program Keluarga Berencana di Kota Batam. Penelitian ini menggunakan pendekatan kuantitatif dengan metode survei. Hasil penelitian ini adalah data statistik deskriptif implementasi program Keluarga Berencana di Kota Batam. Hasil penelitian ini diharapkan mampu menjadi rekomendasi bagi pemerintah khususnya dalam penerapan program Keluarga Berencana di Kota Batam agar dapat berjalan dengan optimal.
Baveno-VII criteria to predict decompensation and initiate non-selective beta-blocker in compensated advanced chronic liver disease patients
Authors: Wong Yu Jun , Zhaojin Chen , Tosetti Guilia , Degasperi Elisabetta , Sharma Sanchit , Agarwal Samagra , Chuan Liu , Huak Chan Yiong , Jia Li , Xiaolong Qi , Saraya Anoop , Primignani Massimo
Published: September 2022

Background/Aims: The utility of Baveno-VII criteria of clinically significant portal hypertension (CSPH) to predict decompensation in compensated advanced chronic liver disease (cACLD) patient needs validation. We aim to validate the performance of CSPH criteria to predict the risk of decompensation in an international real-world cohort of cACLD patients.Methods: cACLD patients were stratified into three categories (CSPH excluded, grey zone, and CSPH). The risks of decompensation across different CSPH categories were estimated using competing risk regression for clustered data, with death and hepatocellular carcinoma as competing events. The performance of “treating definite CSPH” strategy to prevent decompensation using non-selective beta-blocker (NSBB) was compared against other strategies in decision curve analysis.Results: One thousand one hundred fifty-nine cACLD patients (36.8% had CSPH) were included; 7.2% experienced decompensation over a median follow-up of 40 months. Non-invasive assessment of CSPH predicts a 5-fold higher risk of liver decompensation in cACLD patients (subdistribution hazard ratio, 5.5; 95% confidence interval, 4.0–7.4). “Probable CSPH” is suboptimal to predict decompensation risk in cACLD patients. CSPH exclusion criteria reliably exclude cACLD patients at risk of decompensation, regardless of etiology. Among the grey zone, the decompensation risk was negligible among viral-related cACLD, but was substantially higher among the non-viral cACLD group. Decision curve analysis showed that “treating definite CSPH” strategy is superior to “treating all varices” or “treating probable CSPH” strategy to prevent decompensation using NSBB.Conclusions: Non-invasive assessment of CSPH may stratify decompensation risk and the need for NSBB in cACLD patients.
A Comparative Study of Local Dietary Intake Among Subjects with Hypertensive Disorders of Pregnancy Attending Antenatal Care
Authors: Chukwunyere Chibuike F. , Awonuga David O. , Olunuga Taiwo , Udenze Ifeoma C.
Published: September 2022

Background: Hypertensive disorders of pregnancy remain among the most significant causes of pregnancy-related complications. The research by the Dietary Approaches to Stop Hypertension (DASH) group revealed that non-pharmacological measures and intervention such as diet can be used to control blood pressure.

Objective: This study was completed to determine the frequency of consumption of local food among females who were pregnant and their relationship with pregnancy-related hypertensive disorders.

Methods: This was a descriptive research study of females who were pregnant with pre-eclampsia (PE) and gestational hypertension (GH) who presented at the Federal Medical Centre (FMC), Abeokuta, Nigeria. During the study period (September–October 2019) at the tertiary healthcare centre, 45 subjects who were pregnant were select from a PE and GH group, and matched with 45 patients with normotension. Comparison of bean meal onsumption (gbegiri) and bone meal (gbure-oloboro) consumption in subjects who were pregnant did not reveal statistically significant differences in those with PE and GH.

Results: The findings reveal a statistically significant difference in milk consumption between females who were pregnant with mild and severe PE (p=0.019). There was also a statistically significant difference in subjects with mild and severe GH who consumed milk (p=0.003).
Variety of β-glucans: properties, adequate and clinically effective doses
Authors: Kodentsova V. M. , Risnik D. M.
Published: September 2022

A review of the existing literature on the problem in recent years was carried out using the RSCI, CyberLeninka, Pubmed, and ReserchGate databases. Structurally, βglucans are complex natural polysaccharides consisting of monomeric βD-glucose units covalently linked by glycosidic bonds in various positions. βGlucans are found in bacteria, algae, edible fungi (bodies and cultivated mycelium) and cereals. According to the source of origin, βglucans are classified into cereal and non-cereal. Grain-derived βglucans (oats, barley, wheat, and rice) typically have 1,3–1,4 glycosidic linkages with no 1,6-linkages or branches, while non-grain-derived βglucans (baker’s yeast, edible mushrooms, bacteria) have linear (1,3) chains with long branching chains 1,6. The functional properties of βglucans are determined by the length of the backbone (degree of polymerization), the ratio of bonds 1.3:1.4 or bonds 1.3:1.6 (degree of branching), branching interval, side chain size and molecular weight. Grain βglucans are classified as dietary fiber in terms of their properties and mechanism of action. The effective dose of cereal βglucans, which provides efficacy in metabolic disorders (glucose, cholesterol levels) and gastrointestinal functions, as well as a probiotic effect, is from 3 to 8 g (most often 4.5 g) with a duration of intake of at least 3 weeks. Non-cereal (predominantly from fungi and yeast) βglucans have a 1,3 and 1,6 bond structure and are recognized by several receptors including dectin 1, complement receptor 3 (CR 3) and toll-like receptors (TLRs) and have more pronounced immunomodulatory functions. The main mechanisms of their action have been established in vivo experiments or animal models. Non-cereal βglucans are used as adjuvants in drug therapy at doses ranging from 20 mg for the common cold to 750 mg for cancer. In accordance with the domestic legal framework governing the use of food ingredients in the production of dietary supplements and specialized food products, βglucans are not separated by their source of origin. The currently established adequate level of intake of these polysaccharides, regardless of the source of their receipt, is 200 mg/day, and the upper acceptable level is 1000 mg/day. An analysis of literature data indicates the need to differentiate βglucans and increase the permitted doses of cereal βglucans to the level established for soluble dietary fibers.
Development and role of intestinal microbiota in term and preterm newborn babies. Accent on breast feeding
Authors: Gribakin S. G. , Orlova S. V. , Podoprigora I. V.
Published: September 2022

Intestinal microbiota (IM) plays in human organism a number of various functions including a participation in metabolic procecces, stimulation of immune function, competition with pathogenic flora, fermentation activity in colon. Microbial colonization of sterile gastrointestinal tract of newborn is based on several natural principles and depends on mode of delivery, vaginal and fecal flora of own mother, external factors (hospitalization, antibiotic therapy), and as well is regulated by breast feeding or bottle feeding. Besides that there is a proven difference between term and preterm newborn babies. Microbial community (so called Microbiome) of human milk with its complicated microbial society plays a key role in IM development, especially in combination with human milk oligosaccharides evolutionary connected with human intestinal microbiota development.
Optimization of nutrition and the role of dietary supplements for food in the correction of the diet of a modern person
Authors: Orlova S. V. , Nikitina E. A.
Published: September 2022

The task of a healthy diet is to support the body’s resistance to adverse environmental factors and infectious agents, to provide the possibility of restoring health in case of somatic pathology and injuries. Given the growing number of people over working age in the Russian Federation, much attention should be paid to the nutrition of older people in order to maintain active longevity, physical and mental activity. Of great importance is the nutrition of a pregnant woman, since it affects not only the condition of the mother and fetus, but also programs the activity of metabolic processes in a child in adulthood. To individualize and optimize the nutrition of an individual, biologically active food supplements can be used, taking into account gender, age, level of physical activity and the physiological state of a person. Appointment and issuance of prescription forms for dietary supplements for food should not be carried out, because Dietary supplements are not medicines. However, dietary supplements should be recommended by doctors to healthy and sick people to optimize, correct and enrich the diet for the purpose of diet therapy and dietary prevention.
Algae and omega-3 PUFAs
Authors: Prokopenko E. V. , Orlova S. V. , Nikitina E. A.
Published: September 2022

Nutrition plays a critical role in health promotion and disease prevention, while nutrition-related factors are in many cases key risk factors contributing to morbidity and mortality. The “modern” diet is increasingly leading to health problems such as overweight and obesity, type 2 diabetes, some types of cancer, neurodegenerative and other diseases. In recent years, there has been a growing interest in polyunsaturated fatty acids (PUFAs) due to their positive effects on human health. This correlates with the ever-increasing demand for two omega-3 PUFAs, eicosapentaenoic acid and docosahexaenoic acid (EPA and DHA). Humans cannot synthesize omega-3 PUFAs de novo or produce them from their precursors in sufficient quantities. Thus, they must be obtained from food or means that allow you to adjust the diet of a person. Therefore, it is important to find sustainable ways to provide PUFAs to meet demand.
Perlawanan Sangia Dowo (Sangia Nilemba), Raja Kerajaan Moronene Poleang Terhadap Kolonialisasi Belanda, 1906-1912
Authors: Fikriansyah Diky
Published: September 2022

Tujuan penelitian ini adalah untuk: (1) Mendeskripsikan perlawanan Sangia Dowo (Sangia Nilemba) terhadap hegemoni dan kolonialisasi Belanda di Tanah Kerajaan Moronene. khususnya daerah Kerajaan Moronene Polea. (2) perundingan yang terjadi antara Sangia Dowo (Kerajaan Moronene Polea) dengan Kapten De Jongens (Belanda). (3) Inilah alasan untuk mengangkat Sangia Dowo sebagai pahlawan nasional Indonesia..Metode yang digunakan dalam penelitian ini yaitu metode sejarah yang terdiri dari lima tahap, yaitu: (1) Pemilihan topik, terbagi dua bagian yakni kedekatan dan kedekatan pendekatan, (2) Heuristik sumber, terdiri dari studi dokumen, studi kepustakaan, wawancara dan pengamatan, (3) Verifikasi sumber, yang dilakukan melalui kritik eksteren dan kritik interen, (4) Interpretasi sumber, yang dilakukan dengan analisis data dan sintesis, (5) Historiografi, yang dilakukan secara sistematis dan objektif.Hasil penelitian ini menunjukkan bahwa: (1) Ketidaksenangan dan penentangan Sangia Dowo terhadap hegemoni dan kolonialisasi Belanda yang mengakibatkan meletusnya peperangan di antara Kerajaan Moronene Polea melawan penjajah Belanda. (2) Karena ketidakmampuan Belanda menguasai Kerajaan Moronene Polea pimpinan Sangia Dowo, maka pihak Belanda melakukan sebuah tindakan tipu muslihat berupa perundingan dan meracuni Sangia Dowo. (3) Semua kejadian yang terjadi pada Sangia Dowo dan dengan memperhatikan sebab seorang tokoh diangkat menjadi pahlawan nasional, maka Sangia Dowo sangat layak untuk dijadikan pahlawan nasional Indonesia.

Kata Kunci: Sangia Dowo, Kapten De Jongens, Perang, Perjanjian
Partisan Political Beliefs and Social Learning
Authors: Matthews Peter , Robbett Andrea , Colón Lily
Published: September 2022

American politics is currently characterized by polarized beliefs about otherwise verifiable realities, a pathology often ascribed to the influence of “echo chambers” on like-minded partisans. Partisans will seek out the views of like-minded individuals for either instrumental reasons, that is, because co-partisans are presumed to know more, or for expressive reasons, to learn or confirm “partisan congenial” beliefs. We conducted an online experiment to characterize the demand for, and use of, social information about political beliefs. There is mistrust across partisan lines but also a willingness to consult social information in pursuit of “correct beliefs.” The further observation that those who do consult peers are not correct more often underscores the importance of reliable private information as a bulwark against some of the pernicious effects of echo chambers.
Questioning the Influence of Political trust on Individuals’ Unconventional Political Participation in Palestine.
Authors: Darkhalil Mohammed
Published: September 2022

Trust is an important indicator to measure the unconventional political participation, this study relied on the fifth wave of Arab-Barometers 2018-2019 and used ordinal logistic regression to analyze the relationship between political trust and political participation in Palestine. The results show statistically significant positive relationship between trusting political parties and Islamist movement and political participation. Trusting the president, prime minister, and government do not show any statistically significant relationship with political participation. This evidence contradicts with the institutional approach to explain the relationship between trust and political participation.
Penggunaan Komunikasi Nonverbal dalam Perkawinan Campuran
Authors: Biâ€™an Dina Dewita , Waluyo Lukman Saleh , Wiradharma Gunawan
Published: September 2022

Salah satu aspek dalam kajian komunikasi antar budaya adalah komunikasi yang terjadi di antara perkawinan campuran pasangan suami istri yang berasal dari dua latar belakang budaya berbeda. Komunikasi yang berlangsung di antara mereka disebut komunikasi antarbudaya. Artikel ini akan membahas sejauh mana penggunaan komunikasi nonverbal pada proses komunikasi yang berlangsung pada pasangan beda kewarganegaraan. Metodologi yang dipakai adalah kualitatif fenomenologi dengan teknik nonprobabilita purposif sampling. Hasil penelitian ini adalah budaya dan psikologis berpengaruh dalam proses komunikasi seseorang. Fungsi komunikasi nonverbal dalam perkawinan campuran dapat berbeda karena dipengaruhi beberapa hal, salah satunya adalah penggunaan bahasa verbal. Miskomunikasi dapat terjadi ketika orang antarbudaya berkomunikasi. Komunikasi antarbudaya dapat dikatakan efektif apabila kedua pihak dapat secara akurat memprediksi dan menjelaskan perilaku masing-masing.

 

The practice of mixed marriage between husband and wife comes from two different cultural backgrounds, the communication that is different between them is called intercultural communication. The methodology used is qualitative phenomenology with a non-probability purposive sampling technique. This study is conducte to determine the use of nonverbal communication in the communication process that occurs in couples of different nationalities. The results obtained from this study are cultural and psychological influences on a personâ€™s communication process. The function of nonverbal communication in communication in mixed marriages can be different because it is influence by several things, one of which is the use of verbal language. Miscommunication can occur when people across cultures communicate. Intercultural communication can be said to be effective if both parties can accurately predict and explain each otherâ€™s behavior.
Advances in the superhydrophilicity-modified titanium surfaces with antibacterial and pro-osteogenesis properties: A review
Authors: Shao Hanyu , Ma Mingchen , Wang Qiang , Yan Tingting , Zhao Baohong , Guo Shu , Tong Shuang
Published: September 2022

In recent years, the rate of implant failure has been increasing. Microbial infection was the primary cause, and the main stages included bacterial adhesion, biofilm formation, and severe inhibition of implant osseointegration. Various biomaterials and their preparation methods have emerged to produce specific implants with antimicrobial or bactericidal properties to reduce implant infection caused by bacterial adhesion and effectively promote bone and implant integration. In this study, we reviewed the research progress of bone integration promotion and antibacterial action of superhydrophilic surfaces based on titanium alloys. First, the adverse reactions caused by bacterial adhesion to the implant surface, including infection and bone integration deficiency, are briefly introduced. Several commonly used antibacterial methods of titanium alloys are introduced. Secondly, we discuss the antibacterial properties of superhydrophilic surfaces based on ultraviolet photo-functionalization and plasma treatment, in contrast to the antibacterial principle of superhydrophobic surface morphology. Thirdly, the osteogenic effects of superhydrophilic surfaces are described, according to the processes of osseointegration: osteogenic immunity, angiogenesis, and osteogenic related cells. Finally, we discuss the challenges and prospects for the development of this superhydrophilic surface in clinical applications, as well as the prominent strategies and directions for future research.
Application of optical tweezers in cardiovascular research: More than just a measuring tool
Authors: Yang Yi , Fu Zhenhai , Zhu Wei , Hu Huizhu , Wang Jian’an
Published: September 2022

Recent advances in the field of optical tweezer technology have shown intriguing potential for applications in cardiovascular medicine, bringing this laboratory nanomechanical instrument into the spotlight of translational medicine. This article summarizes cardiovascular system findings generated using optical tweezers, including not only rigorous nanomechanical measurements but also multifunctional manipulation of biologically active molecules such as myosin and actin, of cells such as red blood cells and cardiomyocytes, of subcellular organelles, and of microvessels in vivo. The implications of these findings in the diagnosis and treatment of diseases, as well as potential perspectives that could also benefit from this tool, are also discussed.
The impact of serum-free culture on HEK293 cells: From the establishment of suspension and adherent serum-free adaptation cultures to the investigation of growth and metabolic profiles
Authors: Jang Mi , Pete Ellen Sofie , Bruheim Per
Published: September 2022

Serum-free cultures are preferred for application in clinical cell therapy and facilitate the purification processes of bioproducts, such as vaccines and recombinant proteins. It can replace traditional cell culture - eliminating potential issues posed by animal-derived serum supplementation, such as lot to lot variation and risks of pathogen infection from the host animal. However, adapting cells to serum-free conditions can be challenging and time-consuming, and is cell line and medium dependent. In addition, the knowledge of the impact of serum-free culture on cellular metabolism is limited. Herein, we successfully established serum-free suspension and adherent cultures through two adaptation procedures for HEK293 cells in serum-free Freestyle 293 medium. Furthermore, growth kinetics and intracellular metabolic profiles related to central carbon metabolism were investigated. The entire adaptation procedure took 1 month, and high cell viability (>90%) was maintained throughout. The serum-free adherent culture showed the best growth performance, measured as the highest cell density and growth rate. The largest differences in metabolic profiles were observed between culture modes (adherent vs. suspension), followed by culture medium condition (control growth medium vs. serum-free medium). Metabolic differences related to the adaptation procedures were only seen in suspension cultures. Interestingly, the intracellular itaconate concentration was significantly higher in suspension cells compared to adherent cells. Furthermore, when the cells back-adapted from serum-free to serum-supplemented control medium, their metabolic profiles were immediately reversed, highlighting the effect of extracellular components on metabolic phenotype. This study provides strategies for efficient serum-free cultivation and deeper insights into the cellular responses related to growth and metabolism responses to diverse culture conditions.
Single-cell transcriptome profiling reveals several LncRNAs differentially expressed in idiopathic germ cell aplasia
Authors: Lavorgna Giovanni , Tascini Anna Sofia , Bertini Alessandro , Lanzaro Francesco , Montorsi Francesco , Alfano Massimo , Salonia Andrea
Published: September 2022

Mechanisms underlying severe male infertility are still largely elusive. However, recently, a single-cell transcription study by our group identified several differentially expressed coding genes in all the somatic cell types in testes of patients with idiopathic germ cell aplasia (iGCA). Here, we leverage this work by extending the analysis also to the non-coding portion of the genome. As a result, we found that 43 LncRNAs were differentially expressed in the somatic cells of these patients. Interestingly, a significant portion of the overexpressed LncRNAs was found to be a target of TAF9B, a transcription factor known to be involved in germ cell survival. Moreover, several overexpressed LncRNAs were also found to be activated in a mouse model of Sertoli cells treated with bisphenol A, a widespread environmental contaminant, long suspected to impair male fertility. Finally, a literature search for MEG3, a maternally imprinted LncRNA overexpressed as well in our patients, found it to be involved, among other things, in obesity and inflammation, known comorbidities of iGCA, ultimately suggesting that our findings deepen the understanding of the molecular insights coupled not only to the pathogenesis, but also to the clinical course of this class of patients.
Biochemical and physiological insights into TRH receptor-mediated signaling
Authors: Trubacova Radka , Drastichova Zdenka , Novotny Jiri
Published: September 2022

Thyrotropin-releasing hormone (TRH) is an important endocrine agent that regulates the function of cells in the anterior pituitary and the central and peripheral nervous systems. By controlling the synthesis and release of thyroid hormones, TRH affects many physiological functions, including energy homeostasis. This hormone exerts its effects through G protein-coupled TRH receptors, which signal primarily through Gq/11 but may also utilize other G protein classes under certain conditions. Because of the potential therapeutic benefit, considerable attention has been devoted to the synthesis of new TRH analogs that may have some advantageous properties compared with TRH. In this context, it may be interesting to consider the phenomenon of biased agonism and signaling at the TRH receptor. This possibility is supported by some recent findings. Although knowledge about the mechanisms of TRH receptor-mediated signaling has increased steadily over the past decades, there are still many unanswered questions, particularly about the molecular details of post-receptor signaling. In this review, we summarize what has been learned to date about TRH receptor-mediated signaling, including some previously undiscussed information, and point to future directions in TRH research that may offer new insights into the molecular mechanisms of TRH receptor-triggered actions and possible ways to modulate TRH receptor-mediated signaling.
Design, synthesis and cytotoxic evaluation of novel betulonic acid-diazine derivatives as potential antitumor agents
Authors: Shu Yisong , Li Feifei , Han Yaotian , Wang Penglong , Gao Feng , Yan Mengmeng , Liang Miao , Ma Qiang , Zhang Yuzhong , Ding Xia , Lei Haimin
Published: September 2022

With the purpose to improve antiproliferative activity, 26 new betulonic acid-diazine derivatives were designed and synthesized from betulinic acid. The anticancer activity of these semi-synthetic compounds was evaluated by MTT assay in both tumor cell lines and normal cell line. The results indicated that majority of new compounds exhibited improved antitumor activity compared with the parent compound betulonic acid. Compound BoA2C, in particular, had the most significant action with IC50 value of 3.39 μM against MCF-7 cells, while it showed lower cytotoxicity on MDCK cell line than cisplatin. Furthermore, we discovered that BoA2C strongly increased MCF-7 cell damage mostly by influencing arginine and fatty acid metabolism. In addition, the structure-activity relationships were briefly discussed. The results of this study suggested that the introduction of different diazines at C-28 could selectively inhibit different kinds of cancer cells and might be an effective way to synthesize potent anticancer lead compound from betulonic acid.
Bio-hydrogen production by dark anaerobic fermentation of organic wastewater
Authors: Qu Xinghong , Zeng Hongxue , Gao Yongsheng , Mo Tiande , Li Yu
Published: September 2022

Using organic wastewater to produce hydrogen by fermentation can generate clean energy while treating wastewater. At present, there are many inhibitory factors in the hydrogen production process, resulting in unsatisfactory hydrogen yield and hydrogen concentration during the fermentation process, and there are still great obstacles to the industrial promotion and commercial application of organic wastewater fermentation hydrogen production. This paper summarizes the hydrogen production of organic wastewater dark anaerobic fermentation technology. The current anaerobic fermentation hydrogen production systems and technologies are summarized and compared, and the factors and potential conditions that affect the performance of hydrogen production are discussed. The further requirements and research priorities for the market application of fermentation biohydrogen production technology in wastewater utilization are prospected.
Anti-inflammatory role of SGLT2 inhibitors as part of their anti-atherosclerotic activity: Data from basic science and clinical trials
Authors: Scisciola Lucia , Cataldo Vittoria , Taktaz Fatemeh , Fontanella Rosaria Anna , Pesapane Ada , Ghosh Puja , Franzese Martina , Puocci Armando , De Angelis Antonella , Sportiello Liberata , Marfella Raffaele , Barbieri Michelangela
Published: September 2022

Atherosclerosis is a progressive inflammatory disease leading to mortality and morbidity in the civilized world. Atherosclerosis manifests as an accumulation of plaques in the intimal layer of the arterial wall that, by its subsequent erosion or rupture, triggers cardiovascular diseases. Diabetes mellitus is a well-known risk factor for atherosclerosis. Indeed, Type 2 diabetes mellitus patients have an increased risk of atherosclerosis and its associated-cardiovascular complications than non-diabetic patients. Sodium-glucose co-transport 2 inhibitors (SGLT2i), a novel anti-diabetic drugs, have a surprising advantage in cardiovascular effects, such as reducing cardiovascular death in a patient with or without diabetes. Numerous studies have shown that atherosclerosis is due to a significant inflammatory burden and that SGLT2i may play a role in inflammation. In fact, several experiment results have demonstrated that SGLT2i, with suppression of inflammatory mechanism, slows the progression of atherosclerosis. Therefore, SGLT2i may have a double benefit in terms of glycemic control and control of the atherosclerotic process at a myocardial and vascular level. This review elaborates on the anti-inflammatory effects of sodium-glucose co-transporter 2 inhibitors on atherosclerosis.
Peripheral artery disease, abnormal ankle-brachial index, and prognosis in patients with acute coronary syndrome
Authors: Berkovitch Anat , Iakobishvili Zaza , Fuchs Shmulik , Atar Shaul , Braver Omri , Eisen Alon , Glikson Michael , Beigel Roy , Matetzky Shlomi
Published: September 2022

Objectives

Ankle-brachial index (ABI) is an independent prognostic marker of cardiovascular events among patients with coronary artery disease (CAD). We aimed to investigate the outcome of patients hospitalized with acute coronary syndrome (ACS) and abnormal ABI.

Approach and results

ABI was prospectively measured in 1,047 patients hospitalized due to ACS, who were stratified into three groups, namely, those with clinical peripheral artery disease (PAD) (N= 132), those without clinical PAD but with abnormal (< 0.9) ABI (subclinical PAD;N= 148), and those without clinical PAD with normal ABI (no PAD;N= 767). Patients were prospectively followed for 30-day major adverse cardiovascular event (MACE) and 1-year all-cause mortality. The mean age was 64 years. There was a significant gradual increase throughout the three groups in age, i.e., the incidence of prior stroke, diabetes mellitus, and hypertension (p for trend = 0.001 for all). The in-hospital course showed a gradual rise in the incidence of complications with an increase in heart failure [2.5, 6.1, and 9.2%, (p for trend = 0.001)] and acute kidney injury [2, 4.1, and 11.5%, (p for trend = 0.001)]. At day 30, there was a stepwise increase in MACE, such that patients without PAD had the lowest rate, followed by subclinical and clinical PADs (3.5, 6.8, and 8.1%, respectively, p for trend = 0.009). Similarly, there was a significant increase in 1-year mortality from 3.4% in patients without PAD, through 6.8% in those with subclinical PAD, to 15.2% in those with clinical PAD (p for trend = 0.001).

Conclusion

Subclinical PAD is associated with poor outcomes in patients with ACS, suggesting that routine ABI screening could carry important prognostic significance in these patients regardless of PAD symptoms.
Cardiovalve in mitral valve position—Additional solution for valve replacement
Authors: Sherif Mohammad , Sündermann Simon H. , Maisano Francesco , Pieske-Kraigher Elisabeth , Riess Juliane , Reinthaler Markus , Mai Gunther , Trippel Tobias Daniel
Published: September 2022

We report on a 72 years old male patient with recurrent heart failure hospitalizations caused by severe mitral regurgitation due to severe restriction of the posterior mitral leaflet treated with the transfemoral mitral valve replacement (TMVR) system Cardiovalve. Immediate interventional success was obtained resulting in a quick mobilization and discharge.
Relation of quantitative flow ratio with transit time coronary artery bypass graft flow measurement
Authors: Chen Cong , Zhao Yang , Li Wei , Zhang Kui , Dang Haiming , Liu Taoshuai , Song Yue , Zheng Jubing , Dong Ran
Published: September 2022

Background

Quantitative flow ratio (QFR) is a new functional index to assess the functional significance of coronary stenosis. While whether there is an association between QFR and transit-time flow measurement (TTFM) parameters of the target coronary artery has not been well addressed.

Methods

A total of 89 patients receiving the in situ left internal thoracic artery (LITA) grafts to the left anterior descending artery (LAD), and 19 patients undergoing the saphenous vein grafts (SVG) were enrolled in this retrospective study. The QFR value of the LAD was evaluated preoperatively. According to the QFR values, patients with the LITA to the LAD bypass grafts were divided into two groups (group A1: QFR < 0.75, group A2: QFR ≥ 0.75), and SVG patients were divided into two groups (V1 group: QFR < 0.75, V2 group: QFR ≥ 0.75).

Results

In groups A1 and A2, respectively, median graft flow (Qm) was 44 (34) mL/minute and 26.5 (30.0) ml/minute; median pulsatility index (PI) was 2.00 (1.00) and 2.65 (0.90). Significant differences were observed in Qm (P = 0.034) and PI (P = 0.030). And the correlation coefficients of the TTFM variables with QFR were Qm: r = r = −0.226, (P = 0.036), PI: r = 0.265 (P = 0.012) among the LITA to LAD population.

Conclusion

TTFM variables, especially the PI, of the LITA in situ graft to the LAD during Coronary artery bypass grafting (CABG) are strongly affected by preoperative QFR values. Moreover, in functionally mild coronary stenosis, the chance of competitive flow increases.
Changing the research paradigm for digital transformation in healthcare delivery
Authors: Regan Elizabeth A.
Published: September 2022

The growing focus on healthcare transformation (i.e., new healthcare delivery models) raises interesting issues related to research design, methodology, and funding. More than 20 years have passed since the Institute of Medicine first called for the transition to digital health with a focus on system-wide change. Yet progress in healthcare delivery system change has been painfully slow. A knowledge gap exists; research has been inadequate and critical information is lacking. Despite calls by the National Academies of Science, Engineering, and Medicine for convergent, team-based transdisciplinary research with societal impact, the preponderance of healthcare research and funding continues to support more traditional siloed discipline research approaches. The lack of impact on healthcare delivery suggests that it is time to step back and consider differences between traditional science research methods and the realities of research in the domain of transformational change. The proposed new concepts in research design, methodologies, and funding are a needed step to advance the science. The Introduction looks at the growing gap in expectations for transdisciplinary convergent research and prevalent practices in research design, methodologies, and funding. The second section summarizes current expectations and drivers related to digital health transformation and the complex system problem of healthcare fragmentation. The third section then discusses strengths and weaknesses of current research and practice with the goal of identifying gaps. The fourth section introduces the emerging science of healthcare delivery and associated research methodologies with a focus on closing the gaps between research and translation at the frontlines. The final section concludes by proposing new transformational science research methodologies and offers evidence that suggests how and why they better align with the aims of digital transformation in healthcare delivery and could significantly accelerate progress in achieving them. It includes a discussion of challenges related to grant funding for non-traditional research design and methods. The findings have implications broadly beyond healthcare to any research that seeks to achieve high societal impact.
The challenge of developing ecohydrological metrics for vegetation communities in calcareous fen wetland systems
Authors: Bijkerk Ella , Regan Shane , Johnston Paul M. , Coxon Catherine , Gill Laurence W.
Published: September 2022

Calcareous fens are peat-wetlands fed mainly by groundwater, located in topographic hollows and served by springs or seepages of water derived by contact with base-rich mineral ground. In the European Union they are protected habitats requiring special conservation measures. To better understand the environmental supporting conditions of alkaline fen habitat found in Ireland, a 2-years hydrological and hydrochemical monitoring programme was carried out on four contrasting fen sites that covered an ecohydrological gradient representing intact to highly degraded conditions. This paper presents a methodology (and its limitations) of how the evaluation of the temporal and spatial variability of the quality and hydrological dynamics associated with different representative vegetation communities within the four fens can be used to develop ecohydrological metrics for fen habitat. The conditions supporting fen habitat in “good” ecological condition, indicative of a functioning alkaline habitat, were determined and contrasted with conditions found in habitats deemed to be in “poor” ecological condition. Results indicate that an annual water level always above the ground surface within a threshold depth envelope of between 0.030 and 0.28 m is required for at least 60% of the year for healthy fen vegetation. In terms of hydrochemistry, higher concentrations of nutrients were found in the sediments at depth and the groundwater feed compared to the phreatic water table. This suggests the fens may be incorporating the incoming nutrients into their internal biogeochemical cycles and that there is a net accumulation of nutrients within the wetlands. Although envelopes of nutrient concentrations in the surface water of the fen associated with habitat in good ecological condition can be defined (e.g., dissolved reactive phosphorus concentrations of between 6 and 37 µg-P/l for PF1 habitat), these levels should be regarded as the water quality after the fen vegetation has effectively interacted with the higher incoming nutrient levels in the groundwater. Moreover, the local hydrogeological conditions that define groundwater pathways (and associated water quality impacts) in such calcareous fens, allied to the localized nature of these measurements in these field studies, makes it difficult to define groundwater water quality threshold values with any confidence.