bluuebunny/crossref_metadata_2025 huggingface dataset:
İSLAMCILIK OLARAK MİLLİYETÇİLİK: İSMET ÖZEL’İN ÇELİMLİ ÇALIM MECMUASI’NDAKİ YAZILARINDA TÜRKLÜK, TÜRKİYE VE ULUSLARARASI SİSTEM SÖYLEMLERİNİN İSLAMCILIK ÇERÇEVESİNDE TAHLİLİ
Authors: ŞAHİN Enes , ŞAHİN Selin
Published: December 2019

Türk
İslamcılığı, modern Türk düşüncesinin en önemli alanlarından birisini ifade
eder. Türk düşünce geleneğinin modernleşme problemine bir cevabı mahiyetinde
olan Türk İslamcılığı, Osmanlı modernleşme tecrübesinden beri kendini farklı
mütefekkirlerin elinden gösterir. Türkiye’de İslamcılık düşüncesi denildiğinde
akla gelen önemli isimlerden biri şüphesiz İsmet Özel olur. Özel, şair ve
düşünce adamı kimliğiyle ortaya koyduğu eserlerinde İslamcılık düşüncesinin
modernleşme devrinden beri çözmeye çalıştığı sorunlara yönelik yeni ve farklı yaklaşımlar
ortaya koyar. Özellikle teknik ve medeniyet gibi İslamcılık düşüncesinin en
fazla benimsediği ve sık kullandığı kavramları tartışmaya açması onun yerini
daha da önemli bir hale getirir. Özel’in düşünce dünyasını ortaya koyduğu
kavramlar zamanla değişir ve özellikle 2007 yılında İstiklâl Marşı Derneği’nin
kurulmasının ardından milliyetçi bir niteliğe bürünür. Dernek bünyesinde
gerçekleştirilen konferans, internet sitesi yazıları ve dergi yayını gibi
faaliyetlerde bu dilin hâkimiyeti daha belirgin hale gelir. İlk dönemden beri
sürekli olarak düşünce dünyasının bir tarafını teşekkül ettiren “dünya sistemi”
kavramı, özellikle bu dönemden itibaren Türklük ve milliyetçilik ile beraber
işlevselleştirilmeye çalışılır. Bu çalışmada, işaret edilen kavramlar, Özel’in
İstiklâl Marşı Derneği tarafından neşredilen Çelimli Çalım mecmuasındaki
yazılarında, İslamcılık düşüncesi çerçevesinde ortaya konulacak ve tetkik
edilecektir. Çalışmanın temel fikri, Özel’in düşünce dünyasının geçmişten
günümüze İslamcı bir nitelik arz ettiği fakat özün aynı kalıp formun değiştiği,
fikirler değişmezken onları ifade etme tarzında farklılaşma olduğudur.
Kullandığı dili dönemin problemleri etrafında şekillendiren Özel’in bu kullanım
tarzı, onun kavram dünyasına derinlikli bir bakış ile açıkça ortaya çıkacaktır.
Yani bu dönemde İsmet Özel’in kullandığı dilde İslamcılık milliyetçilik olarak,
İslam ise Türklük olarak karşımıza çıkmakta fakat işaret edilen hususlar aynı
kalmaktadır.
IRREDUTIBILIDADE E CONSTITUIÇÃO DIALÉTICA DA VIDA ÉTICA NO JOVEM HEGEL
Authors: Drawin Carlos Roberto , Moreira Jacqueline De Oliveira
Published: December 2019

O nosso artigo tem como objetivo mostrar o caráter originário da vida ética no pensamento hegeliano, isto é, a exigência de pensá-la como irredutível à sua gênese empírica, quer na perspectiva do naturalismo, quer na do indivi­dualismo. Com tal propósito tomamos como foco de nossa análise o manuscrito de 1803-1804 que recebeu posteriormente o título de “Sistema de eticidade” ressaltando como a sua constituição dialética implica em ruptura com relação ao pensamento ético e político modernos e, desse modo, oferece fecunda contri­buição para a discussão filosófica contemporânea. Embora sem avançarmos em direção da obra de maturidade do filósofo e permanecendo numa base textual bastante restrita, acreditamos que nela já podemos discernir alguns elementos para a crítica de uma abordagem materialista da ética.
UM CONTO DE DUAS CRISES: PESQUISA E REDAÇÃO DE O CAPITAL ENTRE 1857 E 1868
Authors: Deus Leonardo Gomes de
Published: December 2019

O artigo examina a influência das pesquisas conjunturais de Karl Marx a respeito das crises de 1857 e 1866 sobre o processo de redação de O Capital e, por outro lado, o impacto dessa redação na própria análise marxiana das crises econômicas.
KARL MARX E A DOUTRINA SOCIAL DA IGREJA: RELAÇÕES E DIFERENÇAS FUNDAMENTAIS
Authors: Gasda Élio
Published: December 2019

Catolicismo e Marxismo são tão antagônicos assim? Existe algum ele­mento em comum? Esse debate vem ocupando historiadores e acadêmicos desde a publicação de Rerum Novarum e do pensamento de Karl Marx, que irrompem como reação à Revolução industrial conduzida pela economia de mercado do capitalismo. O artigo descreve, primeiramente, seus pontos de contato: origem cronológica e motivação comum; a exploração do proletariado e a centralidade do trabalho humano. Em seguida, expõe as duas diferenças fundamentais: o marxismo como teoria crítica da economia política e a Doutrina social da Igreja como teologia moral. Quanto ao objetivo: em Marx é alcançar a sociedade comu­nista sem classes. O objetivo da DSI é auxiliar os cristãos a viver a esperança no Reino de Deus, antecipando sua realidade em sinais concretos na história. Em terceiro lugar, o texto aborda os recentes sinais de aproximação entre os dois. Marxismo e Doutrina Social da Igreja continuam atuais.
Dementia Literacy in Greater Bay Area, China: Identifying the At-risk Population and the Preferred Mass Media for Receiving Dementia Information
Authors: Leung Angela Yee Man , Molassiotis Alex , Zhang June , Deng Renli , Liu Ming , Van Iat Kio , Leong Cindy Siu U , Leung Isaac S.H. , Leung Doris Y. P. , Lin Xiaoling , Loke Alice Y
Published: December 2019

Background: This study aimed to assess the dementia literacy (DL) level of community-dwelling adults in the four cities (Hong Kong, Guangzhou, Macau and Zhuhai) of the Greater Bay Area of China and to determine the preferred mass media for receiving dementia information. Methods: A multi-city cross-sectional study with 788 community-dwelling adults completed the survey. Dementia literacy was indirectly measured by two validated scales, 30-item Alzhiemer’s Disease Knowledge Scale (ADKS) and 20-item Dementia Attitudes Scale (DAS). When the ADKS total score was <15 and DAS total score was <70, it was considered as ‘inadequate dementia literacy’. Participants were also asked to indicate whether they would like to receive dementia information via digital media or traditional media. Chi-square tests and logistic regressions were undertaken. Results: About one-third of the participants had inadequate dementia literacy. Those with young age or secondary education preferred to get dementia information from social media. But people living in public housing would like to get information from government or hospital websites. Middle-aged participants inclined to learn dementia from television or radio. Conclusion: It is worthy to conduct territory-wide public education in dementia and develop strategies according to their preferences in the types of mass media.
Acute Coronary Syndromes in Pregnant Women: Diagnosis, Potential Causes, Roadmap in Treatment, Experimental Studies and Hypotheses
Authors: Simdi Ertunc
Published: December 2019

In this study, we wanted to discuss the acute coronary syndromes in the pregnant womens which are very important for life ofthe fetus. Spontaneous coronary artery dissection and management, which is the most common cause of acute coronary syndrome in pregnant women is also discussed. About 300 articles were examined and 35 articles which published in high quality journals with high level of evidence were chosen and this review was prepared.
3,4-DHPEA-EA Peracetylated (3,4-DHPEA-EA(P)) Attenuates H2O2-Mediated Cytotoxicity in C2C12 Myocytes via Inactivation of p-JNK/p-c-Jun Signaling Pathway
Authors: Nardi Monica , Bardelli Sara , Ciriolo Maria Rosa , Colica Carmela , Costanzo Paola , Procopio Antonio
Published: December 2019

Oleuropein, glycosylated secoiridoid present in the olive leaves, is known as an important antioxidant phenolic compound. We studied the antioxidant effect of low dose of oleuropein aglycone (3,4-DHPEA-EA) and oleuropein aglycone peracetylated (3,4-DHPEA-EA(P)) in murine C2C12 myocytes treated with hydrogen peroxide (H2O2). Both compounds were used at a concentration of 10 μM and were able to inhibit cell death induced by H2O2 treatment, with 3,4-DHPEA-EA(P) being more. Under our experimental conditions H2O2 efficiently induced the phosphorylated-active form of JNK and of its downstream target c-Jun. We demonstrated, by Western blot analysis, that 3,4-DHPEA-EA(P) was efficient in inhibiting the phospho-active form of JNK. This data suggest that growth arrest and cell dead of C2C12 proceeds via the JNK/c-Jun pathway. Moreover, we demonstrated that 3,4-DHPEA-EA(P) affects myogenesis of C2C12 cells; because the MyoD mRNA levels and the differentiation process are restored after treatment with 3,4-DHPEA-EA(P). Overall, the results indicate that 3,4-DHPEA-EA(P) prevents ROS-mediated degenerative process by functioning as an efficient antioxidant.
A Case Study of Familiar Gastrointestinal Pathologies at Risk of Cancer. Early Detection of Degenerative Signals by Oxidative Stress Biomarkers
Authors: Ferreri Carla , Marone Maria , Confalone Elena , De Maio Anna , Chatgilialoglu Chrissostomos , Faraone Mennella Maria Rosaria
Published: December 2019

Background: Beyond risk factors such as smoking, obesity and others, gastrointestinal cancer often occurs in families and the risk of getting cancer is passed down from parents to offspring. About 5%-10% of gastrointestinal cancers are hereditary (inherited by a gene mutation from one or both parents, predisposing them to develop cancer in their lifetime). Here we describe the clinical history of family members affected by gastrointestinal pathologies which often leaded to cancer. Methods: The subjects were monitored from May 2006 to December 2017 by collecting periodically clinical and endoscopic data, and performing molecular analyses by assaying two biomarkers , auto-modification of lymphocyte Poly(ADP-ribose)Polymerase as early signal of DNA damage, and erythrocyte membrane lipid composition (Fat Profile). First we focused on the oldest members, nine brothers, and thereafter we considered their offspring. Results: Both groups of subjects developed gastrointestinal pathologies of different kind and seriousness. Some diseases evolved to cancer, sometimes as a sudden and lethal event. The results of the two molecular approaches auto-modification of Poly(ADP-ribose)Polymerase and Fat Profile), were in agreement and even predicted the clinical and imaging paths. Conclusions: Both non-invasive molecular analyses can be used preliminarly to predict altered physiological states and support clinical and imaging analyses.
4G Model of Fractional Charge Strong-Weak Super Symmetry
Authors: Seshavatharam U.V.S. , Lakshminarayana S.
Published: December 2019

To understand the mystery of final unification, in our earlier publications, we proposed that, 1) There exist three atomic gravitational constants associated with electroweak, strong and electromagnetic interactions; and 2) There exists a strong interaction elementary charge (es) in such a way that, it's squared ratio with normal elementary charge is close to inverse of the strong coupling constant. In this context, starting from lepton rest masses to stellar masses, we have developed many interesting and workable relations. We noticed that, electroweak field seems to be operated by a primordial massive fermion of rest energy 585 GeV. It can be considered as the zygote of all elementary particles and galactic dark matter. Proceeding further, with a characteristic fermion-boson mass ratio of 2.27, quarks can be classified into quark fermions and quark bosons. Considering strong charge conservation and electromagnetic charge conservation, fractional charge quark fermions and quark bosons can be understood. Quark fermions that generate observable massive baryons can be called as Fluons. Quark bosons that generate observable mesons can be called as Bluons. By considering a new hadronic fermion of rest energy 103.4 GeV, rest masses of fluons and bluons can be estimated and there by baryon masses and meson masses can be estimated.
PEMULIHAN KUAT TEKAN BETON RINGAN BERSERAT ALUMINIUM PASCA BAKAR DENGAN VARIASI WAKTU WATER CURING
Authors: Mediyanto Antonius , Safitri Endah
Published: December 2019

Tujuan penelitian ini adalah untuk mengevaluai pemulihan kuat tekan beton ringan berserat aluminium pasca bakar dengan variasi waktu water curing. Benda uji berupa silinder dengan diameter 150 mm dan tinggi 300 mm. Bahan penelitian : serat aluminium dengan aspek rasio sebesar 60 dengan panjang 50 mm, semen tipe I, pasir, alwa, air, dan viscocrete. Pengujian berdasarkan SK SNI S–36–1990–03. Dalam penelitian ini proses pemulihan (recovery) sampai waktu 56 hari setelah pembakaran mampu meningkatkan nilai kuat tekan sebesar 144,59% untuk beton ringan, sedangkan untuk beton ringan berserat aluminium peningkatan nilai kuat tekannya sebesar 82,26%. Hal ini berarti proses pemulihan (recovery) sampai waktu 56 hari mampu mengembalikan kekuatan beton seperti sebelum dibakar.
Block-segment search of local extrema of images based on analysis of brightnesses of related pixels and areas
Authors: Nguyen A. T. , Tsviatkou V. Yu.
Published: December 2019

The aim of the work is to develop an algorithm for extracting local extremes of images with low computational complexity and high accuracy. The known algorithms for block search for local extrema have low computational complexity, but only strict maxima and minima are distinguished without errors. The morphological search gives accurate results, highlighting the extreme areas formed by non-severe extremes, however, it has high computational complexity. The paper proposes a block-segment search algorithm for local extremums of images based on an analysis of the brightness of adjacent pixels and regions. The essence of the algorithm is to search for single-pixel local extremes and regions of uniform brightness, comparing the values of their boundary pixels with the values of the corresponding pixels of adjacent regions: the region is a local maximum (minimum) if the values of all its boundary pixels are larger (smaller) or equal to the values of all adjacent pixels. The developed algorithm, as well as the morphological search algorithm, allows detecting all single-pixel local extremes, as well as extreme areas, which exceeds the block search algorithms. At the same time, the developed algorithm in comparison with the morphological search algorithm requires much less time and RAM.
Information system of semantic search of the image to the text of advertising announcement
Authors: Shvets N. G.
Published: December 2019

In connection with the rapid development of information technology, modern society is in need of solving the problems of the accumulation, storage and automated processing of semiotically heterogeneous arrays of texts. An important task of the developed technologies is the search for operational methods for issuing a wide variety of information in accordance with the user’s request. The aim of the proposed work is to develop a computer information system that allows you to select the most appropriate illustration for the given text of the advertisement. In this case, the main content of the text is proposed to be presented in the form of a certain set of main and secondary keywords, and the content of the illustration in the form of a multi-level complex of descriptors. The proximity of these contents (and, accordingly, the correlation between the image and the verbal component of the advertisement) can be determined through the maximum number of matches of support words and descriptors, taking into account their importance. An important feature of this system is the use of a thesaurus method of representing the image content, which is a description of the illustration in the form of a certain set of words and the relations between these words within a certain subject area.
Time trends analysis of statin prescription prevalence, therapy initiation, dose intensity, and utilization
Authors: Liu Yujuan , Lv Xiaoqun , Xie Ning , Fang Zhonghong , Ren Weifang , Gong Yuan , Jin Yan , Zhang Jun
Published: December 2019

Background Statin remains a mainstay in the prevention and treatment of cardiovascular diseases. Statin utilization has evolved over time in many countries, but data on this topic from China are quite limited. This study aimed to investigate the changing trends of statins prescription, as well as detail the statin utilization through a successive longitudinal study. Methods Prescription database was established based on electronic health records retrieved from the hospital information system of Jinshan Hospital, Fudan University from January 2012 to December 2018 in Shanghai, China. The prescription rates and proportions of different statin types and doses among all patients were examined. Sub-analyses were performed when stratifying the patients by age, gender, dose intensity, and preventative intervention. Results During the study period, a total of 51,083 patients, who were prescribed for statins, were included in this study (mean [SD] age, 59.78 [±13.16] years; 53.60% male, n =27, 378). The overall statins prescription rate in which patients increased from 2012 (1.24%, 95% CI: 1.21%-1.27) to 2018 (3.16%, 95% CI: 3.11%-3.20%), P <0.001. Over 90% of patients were given a moderate dose of statins. Our study has witnessed a significant rise in statin therapy in primary and secondary prevention. Patients with a history of coronary and cerebrovascular events (over 32%) were more likely to be prescribed with statins for preventative intervention. Conclusions In conclusion, statins were frequently prescribed and steadily increased over time. However, in clinical practice, statins prescription rate in patients may be sub-optimal in local residents. A coordinated effort among the patient, clinical pharmacist, stakeholders and health system is still needed to improve statin utilization. Keywords: statins, prevalence, cardiovascular disease, initiation, preventative intervention.
Monoglucosyl rutin facilitates recovery from eyestrain in visual display terminal users: a randomized, placebo-controlled, double-blind, crossover study
Authors: Ashigai Hiroshi , Kanaya Tomoka , Fujii Hitomi , Kawachi Yasuji , Kajita Masayoshi
Published: December 2019

BackgroundEyestrain is a serious quality of life problem, especially in the workplace. In particular, work at visual display terminals (VDTs) is a common cause of eyestrain. Currently, there are many workers who work at VDTs and tend to feel eyestrain. Rutin, derived from various food plants such as the Japanese pagoda tree (Styphnolobium japonicum), is a known polyphenol compound. Monoglucosyl rutin (MGR) is a highly water-soluble α-glucose adduct of rutin. Previous studies have demonstrated that rutin improved dry eye and also affected the microvascular blood flow in animal experiments. Based on these findings, we hypothesized that MGR could alleviate eyestrain caused by work at VDTs. In this clinical study, we evaluated whether MGR could improve eyestrain in healthy adults.MethodsThis study was designed as a randomized, placebo-controlled, double-blind, crossover study. Twenty healthy Japanese adults who tended to feel eyestrain were recruited to participate. During the first test period, the participants were asked to drink either a test food containing 377 mg of MGR or a placebo food without MGR. After the food intake, the participants did personal computer work at VDT for 30 min and then relaxed for 20 min. We evaluated the participants’ eyestrain using an objective parameter (high-frequency component 1, HFC1) and subjective parameters (visual analog scale). After 7 days, for the second test period, the participants consumed an alternate food following the same protocol as during the first test period. ResultsThe objective parameter of eyestrain (HFC1) was significantly lower in the MGR group than that in the placebo group. The subjective parameters of eyestrain and waist stiffness were improved in the MGR group in comparison with those in the placebo group.ConclusionsMGR supplementation has the potential to objectively and subjectively improve eyestrain symptoms due to VDT use.
Serum biomarkers of the calcium-deficient rats identified by metabolomics based on UPLC/Q-TOF MS/MS
Authors: Meng Fanyu , Fan Lina , Sun Lin , Yu Qingli , Wang Maoqing , Sun Changhao
Published: December 2019

Background: We previously identified the urinary biomarkers to diagnose calcium deficiency and nutritional rickets by ultra-performance liquid chromatography/quadrupole time-of-flight tandem mass spectrometry (UPLC/Q-TOF MS/MS).To further confirm these biomarkers in vivo, we performed serum metabolomics analysis of calcium deficiency. Methods: A calcium-deficient rat model was established with a low-calcium diet for 12 weeks. Serum-metabolomics-based UPLC/Q-TOF MS/MS and multivariate statistical analysis was performed to identify the alterations in metabolites associated with calcium deficiency in rats. Results: Bone mineral density, serum parathyroid hormone and alkaline phosphatase were significantly decreased in the low-calcium diet group (LCG) compared to the normal calcium diet group (NCG). Serum metabolic-profiling analysis could definitively distinguish between the LCG and NCG and identified25 calcium-deficient biomarkers. Three metabolites (indoxyl sulfate, phosphate, and taurine) of the 25 biomarkers were found in our previous urinary metabolomics study of rats with a calcium deficiency and nutritional rickets. The areas under the curve (AUCs) of these three biomarkers were greater than 0.8, and the combination of any two biomarkers was higher than 0.95. Conclusion: Dietary calcium deficiency induced the alterations of metabolites in the serum of rats, and the three identified biomarkers had relatively high diagnostic values for calcium deficiency in rats.
Factors Influencing Obstetric Home Delivery and Outcome Among Women of Reproductive Age in Dusmareb District, Somalia
Authors: Jama Abdinasir Abdullahi , Arowojolu Ayodele O , Ajay IkeOluwapo O
Published: December 2019

Background: Homebirth (home delivery) is a birth that takes place in a residence rather than in a hospital or a birth center. Aims: The aim of the study is to determine factors influencing obstetric home delivery and the outcomes among women of reproductive age in Dusmareb district, Somalia. Methods: The study was used a descriptive cross-sectional study in Dusamreb district of Somalia with both qualitative and quantitative techniques of data collections and random technique was used to select 228 women of reproductive age. Well-structured questionnaires were administered by the interviewer to participants who gave their consent and also two focus group discussion sessions were conducted with discussion guides. Data were analysed using the Statistical Package for Social Sciences version 20.0. Descriptive , and Inferential statistics were used to test association, with the level of significance set at 5%. Results: The findings of this study show that 41% have had at least one child delivery at home. The mean age of the respondents was 32.9 ± 8.1 years; 15(6.6%) had tertiary education and Women with 4 – 6 children were four times more likely to have a home delivery (OR = 3.65, p = 0.002), Women with employment were 59% less likely to have a home delivery (OR = 0.41, p = 0.009); the study also found as outcome of home delivery that 22% of the women reported their baby was not okay and have taken to hospital, while 41(73.2%) reported the child died within 28 days following delivery while 24 (42.8%), women experienced prolonged labour during their last delivery at home.in the focus group discussion the women reported that there is poor communication relationship between the mothers and health staff. Conclusion: the study is highly recommended the government to create employment for the women,also the hospital directors were recommended to monitor the relationship between the care giver and the pregnant mother.
Clinical Practice of Unsedated Colonoscopy Among the Liver Transplant Recipients
Authors: Xie Man , Mao Tao , Zhang Qun , Tian Zi-bin , Rao Wei
Published: December 2019

Background: The incidence of colorectal cancer was increased in the liver transplant recipients and clinical practice of unsedated colonoscopy among the liver transplant recipients hasn't been fully studied. Our prospective and observational study was conducted in a tertiary hospital to investigate the clinical practice of unsedated colonoscopy among the liver transplant recipients. Methods: Between June 2017 and June 2018, clinical data of the 72 liver transplant recipients received the screening colonoscopy conducted by a same endoscopists was collected. And a group of asymptomatic health examiner of same age and same gender was chosen as control group at a ratio of 1:3. Data of the colonoscopy performance, patient satisfaction and colonoscopy finding were compared between the two groups. Results: No difference was observed between the two groups in the bowel clearance ( P =0.273) , however, cecal intubation time was longer ( P =0.024) and the auxiliary abdominal compression by nurses was more frequent ( P ＜0.01) in liver transplantation group. In term of patient’s satisfaction, postprocedural visual analog scale, the willingness of repeat the same procedure and the four-point Likert scale (no pain, slight pain, moderate pain, severe pain) on the second day were comparable between the two groups. Compared with control group, the incidence of polyps was higher in the liver transplantation group (50.00% (36/72) vs37.04% (80/216), P =0.036), and the incidence of adenomatous polyps(33.33%vs 24.07%, P =0.084) and advanced polyps (11.11%vs 5.56%, P =0.094) were also higher in the liver transplantation group, but no statistical difference was observed. Conclusions: Liver transplantation mildly increases the difficulty of colonoscopy with experienced practitioners, although the patient’s satisfaction was comparable with the common people. Key words: colonoscopy, liver transplantation, visual analogue scale, polyps
Efficacy and safety of modified electroconvulsive therapy for the refractory depression in older patients
Authors: Jiang Xue , Xie Qin , Liu Lian-Zhong , Zhong Bao-Liang , Si Liang , Fan Fang
Published: December 2019

Background: To explore the clinical efficacy and safety of modified electroconvulsive therapy (MECT) in the treatment of elderly patients with refractory depression. Methods : A total of 43 older patients (18 male and 25 female) with refractory depression were enrolled in our study from March 2014 to February 2015, with the average age of 65±4.8 years old. Modified electroconvulsive therapy (MECT) was performed in these patients after physical examinations and anesthesia procedures. Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale (HAMA) were used to assess the efficacy of MECT, and Wechsler Memory Scale (WMS) and mini mental state examination (MMSE) were used to evaluate the memory ability and cognitive function. The preoperative, intraoperative and postoperative care were conducted in patients accompanied by physical diseases. Results: The rate of efficacy was calculated as 67.44% after 4 weeks of MECT treatment. Our results showed HAMA and HAMD scores after 2 weeks of MECT treatment were significantly lower than that before treatment (P<0.05), and the differences were more significant after 4 weeks of MECT treatment (P<0.01). Compared with before treatment, the scores of memory quotient and immediate memory of WMS decreased significantly after 1 week of treatment (P<0.05). However, these events were not be presented with the progress of treatment, except for after 2 weeks of treatment. Our results demonstrated that compared with before treatment, the scores of MMSE significantly increased significantly after 4 weeks of treatment (P<0.05). There were no serious adverse events in all patients, including cardiovascular and cerebrovascular events. Among them, 7 patients had transient blood pressure rise and slight headache, which were relieved spontaneously after resting. Conclusion: MECT is an effective, well tolerated and safe method for the treatment of older patients with refractory depression, which is temporary and reversible for cognitive impairment. MECT can be recommended for the treatment of these patients after conducting effective risk control of comorbid somatic diseases.
Retrospective analysis of thyroid function in drug-free patients with bipolar disorder in China
Authors: Yang Bin , Li Yan Zhong , Wang Qi , Guo Xin Sheng , Zhao Ying , Jiang Feng , Zhang Xiang Yang , Zhang Rui Ling
Published: December 2019

Background Bipolar disorder is a common mental illness with serious consequences. Clinical studies have found that thyroid function may have an impact on patients with bipolar disorder, but there are few relevant studies in China. So this study explores the characteristics of thyroid function in patients with bipolar disorder in China.Methods Using retrospective cohort study and a cross-sectional study, thyroid function tests were performed in inpatients from September 2015 to January 2018 in the Second Affiliated Hospital of Xinxiang Medical University, who were diagnosed with bipolar disorder and were not treated with medications for at least three months before hospitalization.Results We found that the triiodothyronine (T3) and free triiodothyronine (FT3) levels were significantly higher in bipolar mania than in bipolar depression (P < 0.01). The thyroid stimulating hormone (TSH) levels were significantly lower in male than female patients, while the FT3, free thyroxine (FT4) levels were higher in male than female patients (P < 0.01). Patients were divided into two groups: those who used lithium and those who did not. Both groups had a tendency of hypothyroidism after treatment. In addition, the T3 and FT3 levels were significantly higher in manic than in depressive status in those patients who had a transition between mania and depression in 28 patients compared with previous hospitalization (P < 0.05).Conclusion Patients with bipolar disorder may develop thyroid dysfunction at different stages and in male/female sexes.
Emotional repression in patients with chronic inflammatory rheumatism
Authors: Grondin Karine , Lalanne Cécile , Rouanet Stéphanie , Rabin Thibault , Salomon Sarah , Dervaux Alain , Fardellone Patrice , Goeb Vincent
Published: December 2019

Background: This preliminary study was undertaken to assess and compare the psychological profiles of patients with chronic inflammatory rheumatisms (CIRs), rheumatoid arthritis (RA) or spondyloarthritis (SpA), to try to identify a particular emotional profile compared to patients without CIRs. Emotional repression, i.e., a tendency to inhibit the expression of negative feelings and/or unpleasant thoughts, has been the most studied. Methods: This monocenter observational pilot study included patients followed in a university rheumatology department who underwent systematic assessment of different psychological parameters by an experienced psychiatrist. The clinical and biological characteristics of their rheumatisms were collected. Comparisons were performed used Chi 2 or Fisher’s exact tests. Results: Fifty-nine patients were assessed: 47 with CIRs (27 RA and 20 SpA) and 12 non-CIR controls (nine osteoarthritis, and one each viral disease, osteoporosis or osteomalacia). The rates of severe emotional repression, and the rates of severe early life events, were higher in the group of CIR patients than in the control group (respectively P = 0.02, P = 0.02). In contrast, the rates of severe psychological and somatic complaints were significantly higher than in the control group (respectively, P <0.01 and P =0.01). Conclusion: Our results confirm the importance of emotional repression in coping with various traumatic life events which contribute to the etiology and/or evolution of CIRs. They suggest that these patients would probably benefit from psychotherapy in addition to medical management of their CIRs.
The post- noise exposed condition of the normal hearing workers with tinnitus and hyperacusis developed by the chronic occupational noise exposure
Authors: Bae EunBit
Published: December 2019

Background: Noise pollution has been called an invisible killer. It has been a critical issue for the people working in the noisy environments especially in industry and education. This study was conducted to evaluate the differences of neuronal activity between groups, an experimental group is profession in occupational noise environments and a control group is who did not, and all of the subjects had tinnitus or hyperacusis. We used the electroencephalography data from 17 patients. The two experimental subjects were a tinnitus patient and a hyperacusis patient. The fifteen control subjects were seven tinnitus and eight hyperacusis patients and all of the subjects had normal hearing.Results: We compared the brain activity for three states among the groups: after noise-induced state and no sound exposure state for the two experimental subjects, and no sound exposure state for the control group. The activity of the auditory cortex in the experimental group after noise exposure were significantly increased in gamma (p = 0.002) and decreased in delta and theta band. In other brain areas, the rates of the delta, theta, beta 1~3 and gamma for the control group were higher than the experimental subjects for both with or without noise exposure states.Conclusions: Through this study, it was suggested that the professions of tinnitus and hyperacusis with normal hearing in occupational noise environment could be maintain their pathological states by abnormal hyper-activation of the primary and secondary auditory cortex alone.
Identification, evolution and alternative splicing profile analysis of Serine/Arginine-Rich Protein Splicing Factors (SR Proteins) in poplar, Arabidopsis, grape, and papaya
Authors: Wang Hao , Yan Hanwei , He Ting , Wang Yamei , Wang Ruijia , Xiang Yan
Published: December 2019

Alternative splicing (AS) regulates gene expression and produces proteome diversity. Serine/Arginine-Rich Protein Splicing Factors (SR Proteins) are important splicing factors that play significant roles in spliceosome assembly and splicing regulation, and play roles in regulating plant stress. In this report, we analyzed 30 SR genes in Populus trichocarpa, 18 genes in Arabidopsis thaliana, 14 genes in Vitis vinifera and 9 genes in Carica papaya. The SR proteins contained RRM and RS conserved domains, and based on different structural domain organization were divided into six subfamilies (SR, SC, SCL, RS, RSZ and RS2Z). Gene duplication analysis revealed 94 paralogs and 408 orthologs in the four species, and the SR genes had undergone strong purifying selection. A number of stress-related cis-elements (ABRE, LTR, MBS, TC-rich repeats cis-acting element) were identified in the promoters of the SR genes. Microarray and RNA-seq data showed that SR genes expression in different tissues of the four species responded differently to abiotic stress. Poplar, Arabidopsis and grape SR genes had many splice isoforms. Moreover, 26 of 30 poplar SR genes had intron retention (IR) events, and the relative IR rates of 27 intron sites in the poplar SR genes changed significantly under cold, heat, drought and salt stress conditions. This study provides valuable resources for the gene structure, function, and evolution of poplar SR proteins.
New Classification for Bifurcated Mandibular Neural Canal
Authors: Yang Hao , Wu Yue , Hong Pengyu , Hu Yanjia , Tang Zhangui , Li Kun
Published: December 2019

Background: To analyze the occurrence rate of bifurcated neural canal (BMC) by cone beam CT(CBCT) and summarise a new classification for further clinical work and academic communication. Method: Randomly collected the CBCT images of 350 patients. Firstly, we analysed and summarized the BMCs into four types. Second, we did statistics about occurrence. Then we have measured three kinds of distance of Type I and Type II. At last, we compared the advantages and disadvantages about different classifications. Results: Among these 350 patients, we found 110 people with BMC which indicated the occurrence rate of BMC was 31.43%. The most common type was Type I, especially Type I B , and the least was Type III. Vertical distance between the apex of the second molar, the third molar and mandibular canal are 4.36±2.51 mm and 2.45±2.23 mm. Distance from the apex of two molars to the bifurcated spot are 15.87±6.82mm and 9.32±5.37mm. And the distance between the apex and retromolar foramen in Type I are 22.19±5.97mm and 15.82±4.68mm. Conclusion: Comparing with former typing theory, we summarized a new classification which is simpler and more convenient, which should attach scholars’ attention to BMC during clinical work.
Research on Performance Incentive Mechanism of General Practitioners under the Consideration of Reputation Effect
Authors: zhi-qiang Ma , Bin-xin Zhu
Published: December 2019

BackgroundIn China, General practitioners (GPs) have a weaker reputation than specialists, which leads to their low professional identity. Therefore, GPs’ reputation is a bottleneck restricting their participation in skills training and the realization of the service value of community health centre. Because the GPs’ reputation accumulation can only rely on the improvement of personal skills ,it is necessary to combine the improvement of medical skills to the future economic interests of the GPs, and establishing an effective dynamic reputation incentive mechanism. The purpose of this paper is to explore the dynamic reputation incentive mechanism for GPs, and analyze its performance. MethodsIn this paper, a dynamic incentive model of the GPs in two stages under the effect of explicit and implicit reputation is established and solved by using game theory and agent-principal theory. ResultsThe explicit reputation affects GPs’ determined incomes mainly through fixed awards, and the medical effort input in Stage 1 decreases with the performance award in Stage 2 under the reputation mechanism; the increase of the implicit reputation coefficient can improve the medical performance output, the performance award level and the total value of medical service value, and the explicit reputation correction factor plays the opposite role; when the implicit reputation coefficient and explicit reputation correct factor meet certain conditions, the implementation of reputation incentive can lead to the Pareto effect of GPs’ medical effort and performance awards.Conclusion(1) explicit reputation mainly affects GPs’ deterministic income in Stage 2 by changing the fixed benefits; (2) the medical efforts in the Stage 1 depend on the unit performance incentive coefficient in both stages, and show a certain ratchet effect; (3) implicit reputation can help to improve the level of medical efforts at each stage; (4) the reputation uncertainty will reduce the level of medical efforts and unit performance incentive at each stage; (5) when the explicit reputation correction coefficient is lower than a certain threshold, the implement of reputation incentive can realize the Pareto effect of medical efforts.
Clinicopathological and prognostic involvements of MCT1, MCT4 and IL7R in esophageal squamous cell carcinoma
Authors: Zheng Shutao , Liu Qing , Tan Doudou , Shen Tongxue , Zhang Xiao , Han Xiujuan , Lu Xiaomei
Published: December 2019

BackgroundMCTs, short for monocarboxylate transporters, especially MCT1 and MCT4, have been widely touched upon in a variety of immune and cancer cells; however, they have been rarely described in esophageal squamous cell carcinoma (ESCC). IL7R, receptor of interleukin 7, has been shown to operate in several cancers; though, the clinicopathological implication of IL7R expression in ESCC remains less known. MethodsHerein, to understand the clinicopathological involvements of MCT1, MCT4 and IL7R expression in ESCC, immunohistochemistry was performed with ESCC tissue microarray comprising 86 paired ESCC and its matched normal control dots. Subsequently, statistical analyses ensued. ResultsIt was shown that concomitant expression of MCT1, MCT4 and IL7R prevailed in the stromal compartment of ESCC tissues relative to the epithelial. Moreover, up-regulated MCT1 and MCT4 were markedly associated with tumor size; while IL7R was displayed to closely correlate with lymph node metastases and clinical stage. Elevated MCT1, MCT4 and IL7R were strikingly associated with adverse outcome of ESCC. ConclusionsTogether, the data we presented here indicate that MCT1/4 and IL7R were heavily involved in the oncogenesis of ESCC.
Understanding the structure and function of microbial community in acid mine drainage system of Malanjkhand Copper Project, India
Authors: Gupta Abhishek , Dutta Avishek , Sarkar Jayeeta , Panigrahi Mruganka Kumar , Sar Pinaki
Published: December 2019

Background: Acid mine drainage (AMD) is a worldwide environmental menace with its multifaceted extreme nature, yet, it harbors diverse microorganisms with novel lineages and provides new insights into evolution, adaptation and metabolism. With tight coupling between biological and geochemical processes, AMD microbes play crucial roles in biogeochemical cycles and in constant focus for microbial ecology research through quantitative, genome and metagenome based analysis. This study on microbiome of AMD from Malanjkhand copper mine sheds new light of the general assumptions on microbiome emphasizing the roles of local geochemistry in community assemblages and functions using the samples from an unexplored mine.Results: Malanjkhand AMD samples showed a regime of acidic pH with elevated levels of iron, sulfate and heavy metals. 16S rRNA gene amplicon and metagenome sequencing revealed that environmental pH controlled the species abundance, richness and assemblages. Extreme acidic niches were predominated by chemolithotrophic iron- and sulphur- oxidizing taxa (Leptospirillium, Acidithiobacillus, Ferrithrix, Ferrimicrobium, and Metallibacterium) capable of pyrite dissolution. In contrast, the moderately acidic niches were flourished with heterotrophic populations (Sphingomonas, Nitrosomonas, Gemmatimonas, Meiothermus, Novosphingobium, Polaromonas, Desulfurispora, Desulfomonile) involved in diverse carbon and nitrogen metabolism, sulfate and metal reduction. Relative abundance of taxa, co-occurrence, ANOSIM, and PERMANOVA revealed strength of the selective pressure in habitat-specific microbial guilds. Results indicated that individual species’ ability to withstand and flourish under the extreme low pH environment was an important driver for community association, while metabolic interdependencies could be the major factor controlling species interaction within relatively higher pH habitats. Gene abundance in the metagenomes suggested that sulfur/iron oxidizing, carbon fixing, denitrifying, and stress tolerant microbial populations were predominated in both the samples. Metagenome analysis further revealed that only a small set of sulfate/metal reducing populations was abundant in higher pH samples, indicating their potential in natural attenuation of AMD.Conclusion: Our study provided a deeper understanding about the composition and function of microbial communities within AMD highlighting the roles of local geochemistry in regulating species abundance, distribution, and interrelations. Genomic potential of AMD microbiome in withstanding the extremities and role in biogeochemical cycles, affecting metabolism as well as fate of major hazardous constituents was elucidated.
Penerapan K-Nearest Neighbour dalam Penerimaan Peserta Didik dengan Sistem Zonasi
Authors: Kurniawan Denni , Saputra Ade
Published: December 2019

Admission of new students is a routine activity at the beginning of each new meeting year in all formal educational institutions. At the moment the acceptance of new students uses the zoning system and has been regulated by Permendikbud No. 20 in 2019. This zoning system will accept students where their residence enters through the user area with the school environment. With this Permendikbud the government hopes that there will be an evenness in the quality of education in all schools, so that schools will no longer get the title of superior and non-superior schools. But in a system, the zoning improves anxieties in the school environment. This research supports to help the participating school students will be accepted in accordance with the provisions of the Ministry of Education and Culture. In overcoming problems that arise in the school environment there needs to be a system that can overcome that problem. In this study using the K-Nearest Neighbor (K-NN) method. Where the K-NN method will do the classification of new learners' residence with the school. In determining the classification using the K-NN method used for zoning and non-zoning areas, it is seen based on the closest K value. In finding the optimal value in this study using the Rapidminer application. The optimal high-level test results at K 5 where the value of this K is 83.36%
Pengembangan Sistem Informasi Pada Local E-Govervenance Untuk Peningkatan Kinerja Pelayanan Warga
Authors: Yutanto Hariadi , Ilham Romi , Salma Kautsar Riza , Effendi Yusuf
Published: December 2019

The problems that often arise in the neighborhood of Neighborhood Unit (RT) and Rukun Warga (RW) are the distribution of information on citizen activities, administration, transparent financial management, and management of citizen databases as an effort to improve services and information facilities for residents. The purpose of this study is to support the government in implementing e-Government-based government systems, by developing Good Local Governance. The specific target of innovation to be achieved is the development of innovation in the form of a web-based Citizen Information System (SiWarga) application at the RT / RW level. The method used in this study uses the System Development Life Cycle (SDLC Waterfall) method, starting from the first is analyzing the needs by conducting a survey and the feasibility of developing the system, second is to make a detailed list according to system requirements specifications, third is to design the system by creating workflow designs and programming design, the fourth is the development of information systems with coding, the fifth is system testing, the sixth is the implementation and maintenance of the system
Yeme- İçme Kültürü Mekânları: Pekmezlik/ Pekmez Damı, Antalya Çukurköy Örneği
Authors: Akkaya Ayşe Kübra , Şimşek Tolacı Seda
Published: December 2019

Birçok farklı kültürel unsura sahip olan
Anadolu’da, yeme içme kültürünün önemli bir ürünü olan pekmez, yapım geleneği
ve bu kültüre ait alanlar/mekânlar, özgün yönleri ile nitelikli olup
değerlendirilmelidirler. Değişken ve dinamik bir kavram olan kültür içerisinde,
bu unsurun mevcut durumunun belirlenmesi için gerçekleştirilmesi gereken öncelikli
basamaklar mevcuttur. Bunlar; gerekli bilgilerin toplanması, tespitlerin
yapılması ve belgelendirme işlemidir. Görsel analiz yöntemi, krokilendirme ve
fotoğraf çekimi ile belgeleme çalışması desteklenmiş, yerel halk ile sözlü
görüşmeler yapılmıştır.  Çalışma hedefi
doğrultusunda, bütüncül bir koruma anlayışı ile pekmez yapım geleneği, somut ve
somut olmayan kültürel miras kapsamında ele alınmıştır. Antalya/Çukurköy
yerleşiminde kırsal mimari özellik taşıyan pekmez damları/işlikleri tespit
edilerek, farklı mimari özellikleri kapsamında değerlendirilmiştir. Tespit
edilen 15 adet yapıya dair elde edilen çeşitli veriler, belgelemenin
gerekliliklerine göre; kroki çizimleri, fotoğraflar, tabloların ve tespit
fişlerinin hazırlanması, karşılaştırmalar, vb. farklı şekillerde aktarılmıştır.
ÇOBAN BAYRAMI: SUDAN KOYUN GEÇİRME (DENİZLİ-ÇAL-AŞAĞISEYİT)
Authors: Koyuncu Okca Ayşegül
Published: December 2019

Çobanlar koyun ve keçi yetiştiriciliğinde
önemli bir yere sahiptir. Sürüyü, yıl boyunca yaylada otlatacak olan kişinin;
sadık, işinin ehli olması istenir. Bir koyun sürüsünün sağlıklı, verimli ve
sahibine yüksek kazanç getirmesinde çoban doğrudan sorumludur. Çok çeşitli halk
eğlenceleri bulunan Türk kültüründe özellikle çobanların ve hayvanların aktif
olarak yer aldığı, doğadaki değişimleri bolluk ve berekete çevirmek için bazı
törenler ile kutlamalar yapılmıştır. Eğlence temelli olarak düzenlenen
etkinliklerde bir oyun aracı olarak yer alan hayvanlar insanlar ile olan
bağlarını da sergilerler. Bu
çalışmada Denizli-Çal-Aşağıseyit’de düzenlenen çoban bayramı olan sudan koyun
geçirme etkinliği detaylı bir şekilde açıklanarak Türk kültüründeki yeri ve
önemine dikkat çekilmiştir. Çalışmanın gerçekleşmesi için yöntem anlayışı ışığında
amaca ulaşmada gerekli araçlar olan literatür taraması, yerinde gözlem,
derinlemesine mülakat ve alan araştırması teknikleri kullanılmıştır. Sudan
koyun geçirme etkinliğinin her aşaması fotoğraflar ile belgelenerek çalışmayı
destekleyici şekilde metin kısmına eklenmiştir.