bluuebunny/crossref_metadata_2025 huggingface dataset:
L’hémophilie, une maladie royale : l’Histoire peut-elle changer le sang, et réciproquement ?
Authors: Levasseur Antoine
Published: September 2024

L’hémophilie est connue depuis l’Antiquité, sans être alors précisément comprise. C’est au cours des XIX e et XX e siècles que sa physiopathologie s’est éclaircie et que la terminologie actuelle est apparue. L’hémophilie était qualifiée de « maladie royale » ; en effet, la célèbre reine Victoria était « conductrice » d’hémophilie B sévère et l’a transmise aux familles royales prussienne, russe et espagnole par le jeu des alliances princières. Cette maladie héréditaire de la coagulation a affaibli l’image des monarchies et a pu participer à des événements politiques majeurs : d’une part, la révolution bolchévique orchestrée par Lénine et l’exécution du tsar Nicolas II et de sa famille et, d’autre part, l’abdication du trône espagnol par le roi Alphonse XIII, suivie de l’ascension au pouvoir du général Francisco Franco. Les incidents des dernières décennies, notamment le drame du sang contaminé, ont conduit à des modifications profondes dans la prise en charge des hémophiles devant l’urgence de la situation. La réaction immédiate de la communauté scientifique, des associations de patients et des laboratoires pharmaceutiques a abouti à des avancées : sécurisation des concentrés de facteurs de la coagulation dérivés du plasma par inactivation virale, ainsi que des dons du sang avec l’adoption de nouvelles méthodes de dépistage systématique des virus, production industrielle de facteurs VIII et IX recombinants, avènement de l’émicizumab rétablissant l’hémostase en l’absence de facteur VIIIa par sa liaison aux facteurs IXa et X.
La cartographie génomique optique et ses applications en onco-hématologie
Authors: Kaltenbach Sophie , Balducci Estelle , Villarese Patrick , Couronné Lucile , Asnafi Vahid
Published: September 2024

La cartographie génomique optique (CGO) est une nouvelle technologie qui révolutionne actuellement la génétique en offrant la possibilité de détecter, à haute résolution, les variants de nombre de copies ainsi que les différentes classes de variants de structure sur l’ensemble du génome. En raison de l’impact crucial des données cytogénétiques et moléculaires dans la prise en charge diagnostique, pronostique et thérapeutique des hémopathies malignes, la CGO est une avancée technologique majeure dans les laboratoires de biologie médicale, en particulier en onco-hématologie. Cette revue détaille ses caractéristiques, sa place parmi les techniques de génétique existantes et ses applications dans les hémopathies malignes, en prenant l’exemple des leucémies aiguës myéloïdes et lymphoblastiques, des syndromes myélodysplasiques, de la leucémie lymphoïde chronique et du myélome multiple.
État des lieux du virus respiratoire syncytial
Authors: Jaouen Tristan , Sabarly Léa , Rameix-Welti Marie-Anne
Published: September 2024

Le virus respiratoire syncytial (VRS) est un virus respiratoire saisonnier hautement contagieux et dont la circulation est mondiale. Il infecte presque la totalité des enfants avant l’âge de deux ans et est responsable de la majorité des cas de bronchiolite et de pneumonie durant les premières années de vie. De plus, les réinfections sont fréquentes tout au long de la vie. Elles sont en règle générale bénignes ou asymptomatiques, mais peuvent être sévères en particulier chez les sujets âgés, les patients immunodéprimés ou présentant des affections cardio-pulmonaires sous-jacentes. La prévention du VRS reste ainsi une priorité majeure de santé publique. À ce jour, deux vaccins et deux anticorps monoclonaux sont autorisés en prophylaxie des infections sévères par le VRS des personnes âgées et des nouveau-nés. La recherche et les nombreux essais cliniques en cours laissent entrevoir un avenir prometteur dans le développement de traitements efficaces.
Les déterminants organisationnels et territoriaux de l’adoption de pratiques agroécologiques : le cas des exploitations laitières françaises
Authors: Galliano Danielle , T. S. Siqueira Tiago , Pauly Olivier
Published: September 2024

L’adoption de pratiques agroécologiques (PAE) constitue une étape majeure pour aller vers une agriculture plus durable. Nous mobilisons le cadre analytique de l’économie de l’innovation et des transitions studies pour explorer les déterminants de l’adoption de 10 PAE. Nous réalisons une analyse économétrique sur une population de 47212 exploitations laitières françaises issues du Recensement Agricole 2010. Les résultats montrent l’importance des caractéristiques structurelles et organisationnelles contribuant au développement des capacités d’absorption telles que la taille, le mode de gouvernance et la gestion des incertitudes dans l’adoption des PAE. Ils mettent également en exergue le rôle incitatif de la réglementation et surtout l’influence majeure des processus territoriaux de proximité géographique. En termes de politique publique et du fait de la forte dynamique territorialisée de l'agriculture, encourager le développement des circuits courts, des espaces locaux d'échanges pourrait favoriser l’adoption des PAE et contribuer à la transition vers une agriculture plus durable.
Les conditions de mise en œuvre du principe de subsidiarité pour organiser l’autonomie au travail : réflexion autour de l’entreprise libérée
Authors: Grevin Anouk , Préchoux Véronique
Published: September 2024

Les organisations remettant en cause les modèles hiérarchiques, telles que les entreprises libérées, posent la question de la coordination de l’autonomie offerte aux salariés, pour permettre l’action collective. La mobilisation du principe de subsidiarité fournit des pistes de réflexion. L’article cherche à analyser les conditions de mise en œuvre du principe de subsidiarité pour organiser l’autonomie au travail. Une recherche-intervention dans une savonnerie s’inscrivant dans la philosophie des entreprises libérées permet de constater que la démarche de libération et l’autonomie qui en découle génèrent certaines difficultés (problèmes de coordination et de priorisation, de prise de décision, sentiment d’un manque de soutien), qui font écho au concept de subsidiarité. Ces résultats conduisent à discuter les conditions d’un management subsidiaire, facilitant la prise de décision, reconnaissant le droit à l’erreur et le droit à l’incompétence, et pensant et organisant le soutien dans l’organisation.
La participation des représentants salariés au comité de rémunération : une appropriation contrastée par les entreprises du SBF120 ?
Authors: Chebbi Nekhili Dhikra , Gaillard Hugo , Nekhili Mehdi
Published: September 2024

Les comités spécifiques sont souvent présentés comme des lieux hautement importants dans la prise de décision, et qui, par leur élargissement aux administrateurs représentants salariés, contribuent à une gouvernance plus partagée. Dans ce cadre, nous nous intéressons spécifiquement au comité de rémunération qui fait l’objet d’une recommandation au sein du code Afep-Medef quant à la participation d’un administrateur représentant les salariés à ses travaux. Le non-respect de cette recommandation est selon nous un signal de résistance à la codétermination. A travers l’analyse des documents d’enregistrement universel, complétée par des entretiens semi-directifs, nos résultats mettent en avant la résistance de certaines entreprises françaises à la participation des représentants des salariés au dit-comité, à travers l’analyse des réponses institutionnelles que ces entreprises fournissent. Par ailleurs, ils mettent en avant un contraste en matière d’appropriation de la recommandation chez les entreprises qui l’appliquent.
A Systematic Review of Software for Learning Analytics in Higher Education
Authors: Afzaal Muhammad , Nouri Jalal
Published: September 2024

Learning analytics (LA) is an important area of study in technology-enhanced learning that has emerged during the last decade. In earlier years, several systematic reviews have been conducted that focused on the theories behind LA or on empirical studies that utilized LA-based methods to improve learning and teaching processes in higher education. However, to date, there has been no systematic review of papers that have adopted a software perspective to report on the many forms of learning analytics software (LAS) that have been developed, despite these being used more frequently than before in higher education to support learning and teaching processes. To fill this gap, this paper presents a systematic review of LAS with the aim of critically scrutinizing the ways in which the use of interactive software in real-world settings may both support students in improving their academic performance and assist teachers in various pedagogical practices. A thematic analysis of 75 articles was conducted, resulting in the identification of three categories of LAS: at-risk student identification (ARSI) software; self-regulation software; and collaborative learning software. For each of these categories, we analyzed (i) the embedded functionality; (ii) the stakeholder (teacher and student) for which the functionality is intended; (iii) the analytical and visualization approaches implemented; and (iv) the limitations of the software that require future attention. Based on the findings of our review, we propose future directions for the development of learning analytics software.
A Sociological Take on Language Generative AI Tools
Authors: Tan Chee Shien Victor
Published: September 2024

Language represents the medium in which human experiences are uniquely encoded by how an individual processes and produces language. The development of generative artificial intelligence tools such as ChatGPT created a challenge in the context of education due to how humans, being humans, often employ tools in unconventional ways as hallmarks of our creativity and critical thinking. Efforts to resist the incursion of AI into academic work have evidently failed, as observable from how the Russell Group changed its stance from prior bans on AI to the current acceptance of AI to a large degree (4 July 2023). This acceptance created tremors for the longstanding traditions of knowledge acquisition and production, which many academics are paying increasing attention to. In a bid to better understand the impact of such acceptance, the study was carried out to investigate the impact of AI use for sociological work. Employing a pilot study of a pragmatic approach with 20 graduates, it was found that while there was an even distribution of preference between personal writing and AI writing, academic submission preferences scaled towards AI writing. Preference for AI writing for submission was noted to be twice that of personal writing, despite an even distribution of preference. Findings also noted the qualitative differences between personal writing (268 words with 84 unique words) and AI writing (250 with 10 unique words) in word range and unique words. The analysis notes significant differences in word range between personal writing (± 35.93) and AI writing (± 4.28), reflecting a convergence of writing rhetoric that proves to be largely detrimental to sociological developments. The discussion presents considerations in three dimensions: the challenge on education, the challenge on language education, and the challenge on the sociological lens.
The Effectiveness of an Online Inquiry-Based Learning Environment towards Secondary School Students’ Behavioral Engagement and Performance in Science
Authors: Meng Fangyuan , Jumaat Nurul Farhana Binti
Published: September 2024

The purpose of the current study is to examine the effectiveness of an online inquiry-based learning (IBL) environment on secondary school students’ behavioral engagement and performance in science. In this quasi-experimental design, 90 second year secondary school students from two classes in the Shandong Province region of China were recruited as participants. To gather the data, an online behavioral engagement questionnaire investigation and pre- and post-performance tests were administered to the experimental group (EG) and control group (CG) students. This study result shows that online IBL has a significant impact on secondary school students’ behavioral engagement and performance in science subjects.
Spatial Variation of eDNA Detection Across an Invasion Gradient for Invasive Species Monitoring Programs
Authors: Peterman Laura , Tuttle-Lau Maren , DeHaan Patrick W. , Coulter David P. , Spear Stephen F. , Erickson Richard A.
Published: September 2024

Spatial and temporal distribution data provide critical information for invasive species management. For example, distribution data can help managers with early detection and to guide other response actions. Environmental DNA (eDNA)-based sampling exists as one tool for monitoring invasive species. As part of bigheaded carp Hypophthalmichthys spp. monitoring efforts in the Illinois River, United States, we compared eDNA-based sampling results at multiple habitats across an invasion gradient in 2015. Greater densities of carp occurred downriver in the Illinois River, and lower densities occurred upriver. We sampled from five locations along this gradient and from three habitat types (backwater, main channel, and shoreline) within each location. We sampled each location in April and June. A priori, we hypothesized that 1) more eDNA detections would occur downriver, where higher densities of carp occur, 2) more eDNA detections would occur in backwater habitats than in areas of the river with more fish movement, and 3) more eDNA detections would occur in April because bigheaded carps are thought to use our sampling areas more during the spring. We compared the proportion of samples positive across this gradient, the habitat type, and the two sampling time periods. The most downriver location had the highest proportion of samples with eDNA detections, the backwater habitats had the highest proportion of samples with eDNA detections, and April had more positive detections than June. Our results highlight the importance of sampling across multiple habitat types and across time to gain a clear understanding of distribution when using eDNA-based sampling. Thus, being cognizant of the interactions between seasonal habitat use and eDNA-based detections is important for managers who rely on eDNA-based monitoring.
Exploring Second Language Writing Instruction
Authors: Singh Rini , Srinivas Revathi
Published: September 2024

Current research highlights the problem of low learning outcomes in government schools in India, where students struggle with basic literacy despite years of schooling. In addition to challenges with reading and writing in their first language (L1), writing skills in English as a second language (L2) remain particularly underdeveloped. Part of this issue is attributed to teaching methods that rely heavily on rote memorisation and passive learning. However, there is a lack of quantitative tools to measure L2 writing instruction. This chapter investigates the development and validation of a questionnaire aimed at understanding the teaching of writing skills in English to students in a government school in New Delhi. Content validity, face validity, and internal consistency of the questionnaire were established. The results demonstrate that this is a reliable tool for researchers and educators aiming to understand and improve L2 writing instruction, particularly with students of eighth grade in Delhi government schools, with further validation recommended for broader applicability.
Reliability and Validity of Mixed Methods Research
Authors: Tahir Syeda Rabia
Published: September 2024

This chapter provides a comprehensive guide to conducting reliable and valid mixed methods research, specifically tailored for doctoral scholars. Mixed methods research, blending quantitative and qualitative methodologies, offers a potent approach for delving into complex phenomena. The chapter unfolds in four key steps: design and planning, data collection, data analysis, and reporting and interpretation. In the design and planning phase, considerations such as selecting appropriate research designs, aligning quantitative and qualitative components, sampling strategies, and developing reliable data collection instruments are discussed in detail. Ethical considerations throughout the research process are also underscored. Moving to data collection, the chapter addresses challenges and opportunities unique to mixed methods research, emphasizing vigilance towards threats to reliability and validity, and ethical considerations specific to participant well-being and data integrity.
Association between decreased walking speed and higher-level functional capacity in community-dwelling older women
Authors: Ando Suguru , Iwamura Masaki , Yamato Yosuke , Shinbo Kenji , Nanikawa Wataru
Published: September 2024

This study aimed to investigate the relationship between walking speed and higher-level functional capacity in community-dwelling older women. Data were collected from 91 healthy Japanese women aged ≥65 years (mean age, 78.7 years) in Ibaraki City, Osaka Prefecture. Participants’ higher-level functional capacity was assessed using the Japan Science and Technology Agency Index of Competence (JST-IC). Participants were categorized into two groups based on walking speed (faster or slower than 1.0 m/s). Logistic regression analysis revealed that grip strength [odds ratio (OR): 0.84; 95% confidence interval (CI): 0.713-0.992], the total JST-IC score (OR: 0.82; 95% CI: 0.675-0.997), and the JST-IC subscale for use of technology (OR: 0.54, 95% CI: 0.309-0.958) were significant factors associated with decreased walking speed. The decreased walking speed observed among community-dwelling older women was related to cognitive aspects such as processing and spatial perception, as well as the use of technology. Maintaining physical and cognitive functions, particularly hand function, is crucial for preserving or improving walking speed, a barometer of health.
Visceral muscle dysmotility syndrome in systemic lupus erythematosus: which is the role of 18 fluorodeoxyglucose-positron emission tomography-computed tomography? A clinical case and literature review
Authors: Scriffignano S. , Perrotta F.M. , Ricci M. , Carabellese B. , Lubrano E.
Published: September 2024

Visceral muscle dysmotility syndrome (VMDS) is a rare syndrome, described in the systemic lupus erythematosus (SLE) clinical course. It is characterized by diffuse thickened intestinal wall and gastrointestinal-genitourinary-hepatobiliary hollow viscera dilatation and dysmotility. Due to the rarity and the heterogeneity of the clinical characteristics of this syndrome, it is not entirely clear which is the best diagnostic imaging technique for the diagnosis and/or follow-up, even if, in all the described cases, computed tomography (CT) was generally used to study visceral involvement. However, there are no cases describing the visceral metabolic activity by 18 fluorodeoxyglucose (18FDG)-positron emission tomography-CT (18FDG-PET-CT). Here, we reported the first clinical case of VMDS studied by 18FDG-PET-CT, characterizing the metabolic activity of this rare syndrome during SLE flare. We found a high intestinal metabolic burden, hyper-fixation in duodenum, and high hepatic metabolic activity. Moreover, we reviewed the literature on VMDS in SLE, focusing on imaging techniques in different anatomical sites (bowel, urinary tract, bile ducts), patients' symptoms, and treatment.
Systemic lupus erythematosus induced by anti-tumor necrosis factor α therapy in inflammatory rheumatic diseases: a case series
Authors: Oliveira D. , Martins A. , Martins F. , Gomes C. , Pimenta S. , Vaz C. , Costa L. , Bernardes M.
Published: September 2024

This case series aims to characterize the development of systemic lupus erythematosus (SLE) induced by anti-tumor necrosis factor α (anti-TNFα) therapy in patients with inflammatory rheumatic diseases, namely rheumatoid arthritis (RA), spondylarthritis (SpA), and psoriatic arthritis (PsA). Patients with a diagnosis of SLE induced by anti-TNFα therapy and registered on the Rheumatic Diseases Portuguese Register (Reuma.pt) who started their first anti-TNFα between 2001 and 2020 were included. Demographic, clinical, and laboratory data were obtained by consulting Reuma.pt. The diagnosis of SLE induced by anti-TNFα was considered if there was a temporal relationship between the onset of anti-TNFα therapy and manifestations (clinical and immunological) in accordance with the American College of Rheumatology/European League Against Rheumatism criteria (2019). A total of 607 patients with inflammatory rheumatic diseases and six cases of SLE induced by anti-TNF-α therapy were reviewed: two patients were affected by RA, three patients by SpA, and one by PsA. All these patients had articular and constitutional symptoms that improved after discontinuation of the anti-TNFα agent. After switching to a second anti-TNFα agent, there was no recurrence of SLE over time. The development of SLE secondary to anti-TNFα agents in inflammatory rheumatic patients is rare. In this case series, all patients had a mild disease that improved after therapy discontinuation without recurrence of the disease. SLE induced by anti-TNFα should be considered in the follow-up of RA, SpA, and PsA patients.
Initial Evaluation of lncRNA A2M-AS1 Gene Expression in Multiple Sclerosis Patients
Authors: Mohammadi Shaghayegh , Sadeghiyan Tahereh , Rezaei Mohammad , Azadeh Mansoureh
Published: September 2024

Background:

Multiple sclerosis (MS) is one of the three leading neurodegenerative diseases worldwide. Gene expression profile studies play an important role in recognizing and preventing disease. Considering the inherent ability of biomarkers to diagnose and prognose the occurrence of a disease, with the aim of gene therapy and changing gene expression, it can be helped to treat it. In this study, by examining the gene interaction and expression of non-coding genes in patients with MS, using bioinformatics analyses, laboratory research and potential non-coding diagnostic biomarkers of MS were selected for further investigations.

Materials and Methods:

First, by using micro-array data analysis of the GEO database, the expression status of the long non-coding ribonucleic acid (RNA) (lncRNA) A2M-AS1 gene was investigated in patients with MS. lncRNA–mRNA interaction analysis was performed in the lncRRisearch database. After sample collection, the total RNA extracted using the RNA extraction kit from 20 patient samples and 20 healthy samples was synthesized into cDNA with the synthesis kit. The quantitative reverse transcriptase polymerase chain reaction experiment was performed for the final validation of expression change.

Results:

Based on bioinformatic and laboratory analysis, the expression of the A2M-AS1 gene in MS samples showed a significant decrease in expression compared to healthy samples. Also, based on the receiver operating characteristic analysis, lncRNA A2M-AS1 can be introduced as an acceptable diagnostic biomarker to distinguish MS samples from healthy samples.

Conclusion:

lncRNA A2M-AS1, by reducing its expression as an acceptable diagnostic biomarker, can increase the risk of developing MS.
The dopaminergic system and Alzheimer’s disease
Authors: Zhang Yuhan , Liang Yuan , Gu Yixue
Published: September 2024

Alzheimer’s disease is a common neurodegenerative disorder in older adults. Despite its prevalence, its pathogenesis remains unclear. In addition to the most widely accepted causes, which include excessive amyloid-beta aggregation, tau hyperphosphorylation, and deficiency of the neurotransmitter acetylcholine, numerous studies have shown that the dopaminergic system is also closely associated with the occurrence and development of this condition. Dopamine is a crucial catecholaminergic neurotransmitter in the human body. Dopamine-associated treatments, such as drugs that target dopamine receptor D and dopamine analogs, can improve cognitive function and alleviate psychiatric symptoms as well as ameliorate other clinical manifestations. However, therapeutics targeting the dopaminergic system are associated with various adverse reactions, such as addiction and exacerbation of cognitive impairment. This review summarizes the role of the dopaminergic system in the pathology of Alzheimer’s disease, focusing on currently available dopamine-based therapies for this disorder and the common side effects associated with dopamine-related drugs. The aim of this review is to provide insights into the potential connections between the dopaminergic system and Alzheimer’s disease, thus helping to clarify the mechanisms underlying the condition and exploring more effective therapeutic options.
Blood diagnostic and prognostic biomarkers in amyotrophic lateral sclerosis
Authors: Lv Yongting , Li Hongfu
Published: September 2024

Amyotrophic lateral sclerosis is a devastating neurodegenerative disease for which the current treatment approaches remain severely limited. The principal pathological alterations of the disease include the selective degeneration of motor neurons in the brain, brainstem, and spinal cord, as well as abnormal protein deposition in the cytoplasm of neurons and glial cells. The biological markers under extensive scrutiny are predominantly located in the cerebrospinal fluid, blood, and even urine. Among these biomarkers, neurofilament proteins and glial fibrillary acidic protein most accurately reflect the pathologic changes in the central nervous system, while creatinine and creatine kinase mainly indicate pathological alterations in the peripheral nerves and muscles. Neurofilament light chain levels serve as an indicator of neuronal axonal injury that remain stable throughout disease progression and are a promising diagnostic and prognostic biomarker with high specificity and sensitivity. However, there are challenges in using neurofilament light chain to differentiate amyotrophic lateral sclerosis from other central nervous system diseases with axonal injury. Glial fibrillary acidic protein predominantly reflects the degree of neuronal demyelination and is linked to non-motor symptoms of amyotrophic lateral sclerosis such as cognitive impairment, oxygen saturation, and the glomerular filtration rate. TAR DNA-binding protein 43, a pathological protein associated with amyotrophic lateral sclerosis, is emerging as a promising biomarker, particularly with advancements in exosome-related research. Evidence is currently lacking for the value of creatinine and creatine kinase as diagnostic markers; however, they show potential in predicting disease prognosis. Despite the vigorous progress made in the identification of amyotrophic lateral sclerosis biomarkers in recent years, the quest for definitive diagnostic and prognostic biomarkers remains a formidable challenge. This review summarizes the latest research achievements concerning blood biomarkers in amyotrophic lateral sclerosis that can provide a more direct basis for the differential diagnosis and prognostic assessment of the disease beyond a reliance on clinical manifestations and electromyography findings.
Surgical modalities in the treatment of vitiligo
Authors: Vignesh Narayan R. , Thakur Vishal
Published: September 2024

Vitiligo presents a challenge not only in its medical management but also in its impact on patients’ psychosocial well-being. While medical therapies can halt disease progression, achieving repigmentation, especially in challenging areas, remains a hurdle. Surgical interventions, including therapeutic wounding, camouflage techniques, excision, and grafting methods, offer viable solutions. However, success hinges on assessing disease stability, with various clinical, dermoscopic, and cellular indicators employed for evaluation. Pre-procedure counselling is crucial to manage patient expectations and inform them about potential outcomes and risks. Surgical techniques range from simple excision to complex cellular grafting methods, each tailored to the individual patient’s needs and disease characteristics. Postoperative care, including appropriate dressing and follow-up, plays a significant role in ensuring successful outcomes. Newer techniques, such as automated blister epidermal micrografting and Meek micrografting, show promise in improving efficiency and outcomes. Combining traditional methods with innovations such as transverse needling and micro skin grafting enhances the repertoire of surgical options available. Overall, surgical approaches offer effective means to achieve repigmentation and alleviate the psychosocial burden of vitiligo, highlighting the importance of a multidisciplinary approach in its management.
Equivariant birational geometry of linear actions
Authors: Tschinkel Yuri , Yang Kaiqi , Zhang Zhijia
Published: September 2024

In this paper, we study linear actions of finite groups in small dimensions, up to equivariant birationality.
Spreading, flattening, and logarithmic lag for reaction-diffusion equations in $\mathbb{R}^{N}$: Old and new results
Authors: Hamel François , Rossi Luca
Published: September 2024

This paper is concerned with the large-time dynamics of bounded solutions of reaction-diffusion equations with bounded or unbounded initial support in

\R^{N}

. We start with a survey of some old and recent results on the spreading speeds of the solutions and their asymptotic local one-dimensional symmetry. We then derive some flattening properties of the level sets of the solutions if initially supported on subgraphs. We also investigate the special case of asymptotically conical-shaped initial conditions. Lastly, we reclaim some known results about the logarithmic lag between the position of the solutions and that of planar or spherical fronts expanding with minimal speed, for almost-planar or compactly supported initial conditions. We then prove some new logarithmic-in-time estimates of the lag of the position of the solutions with respect to that of a planar front, for initial conditions which are supported on subgraphs with logarithmic growth at infinity. These estimates entail in particular that the same lag as for compactly supported initial data holds true for a class of unbounded initial supports. The paper also contains some related conjectures and open problems.
Between Scylla and Charybdis: long-term drivers of EU structural vulnerability*
Authors: Guarascio Dario , Reljic Jelena , Cucignatto Giacomo , Simonazzi Annamaria , Celi Giuseppe
Published: September 2024

This work investigates the European Union’s structural vulnerability in an increasingly polarised global economy with ever more ‘weaponised’ interdependencies. Europe’s structural vulnerability is due to different interlinked and mutually reinforcing elements, which are the legacy of a self-defeating export-led growth model and a related economic policy set-up. We define structural vulnerability along four main dimensions – demand, supply, technology and critical raw materials – and discuss its main drivers. Highlighting the key role that Germany plays in shaping the EU growth model, we argue that the vicious circle between demand repression and supply deterioration has constrained innovation and growth, particularly in the southern periphery, making Europe more fragile in the face of external shocks. While acknowledging the recent change in the EU’s industrial policy approach, we argue that inadequate coordination at the EU level and the lack of common resources leave it to the fiscal capacity of individual member states to bridge the technological gap, with the real risk of further widening the core–periphery gap and increasing the structural fragility of the Union.
Exploring counter-cyclical monetary policy in a small open economy using the portfolio balance approach
Authors: Drumond Carlos Eduardo , Razmi Arslan
Published: September 2024

Whether or not the money supply is endogenously determined in response to demand variations has been the subject of recent debates. Regardless of the answer to this question, central banks can and do react to cyclical fluctuations, and their responses, in turn, affect the balance of payments and the foreign asset position. We explore the feasibility of a counter-cyclical monetary policy rule in a small open-economy portfolio balance set-up where assets are imperfect substitutes, capacity utilization endogenously adjusts in a neo-Kaleckian manner to clear the goods market, the exchange rate is flexible, and prices are fixed. This set-up, under some non-restrictive conditions, generates a stable steady-state solution, suggesting that a monetary policy based on a counter-cyclical interest-rate rule is a viable option for macroeconomic stabilization.
Comparison of a linear discrimination function and artificial neural networks approach to discriminate the seismic events in Ankara (Turkey)
Authors: Tan Aylin , Horasan Gündüz , Kalafat Doğan , Gülbağ Ali
Published: September 2024

In this study, natural and blast-induced ground vibrations (namely earthquakes and quarry blasts) in Ankara (Turkey) were analysed and distinguished from each other. A total of 156 digitized vertical component velocity seismograms of seismic events of 2009-2014 with Md≤3.5 were obtained from the Lodumlu broadband station (LOD) controlled by Boğaziçi University, Kandilli Observatory, and Earthquake Research Institute Regional Earthquake-Tsunami Monitoring Center (BU-KOERIRETMC). We examined the following variables: the ratio of the highest amplitude value of the S-wave and the highest amplitude value of the P-wave (Amplitude ratio) of vertical component velocity seismograms, the power ratio (Complexity), the logarithmical value of the amplitude of the S-wave of the seismogram (Log S), and total signal duration of the seismogram. It is the first time that natural and blast-induced ground vibrations were separated from each other using the Fisher’s Linear Discriminate Analysis (FLDA) technique and Artificial Neural Networks (ANNs) approach together in Ankara (The capital of Turkey). Ninety-two (59%) of the 156 seismic events studied were identified as earthquakes and sixty-four (41%) of them were described as blast-induced ground vibrations. Then the obtained accuracy percentage results of three pairs of some variables were compared. The amplitude ratio versus complexity and the amplitude ratio versus total signal duration had a high classification accuracy determination coefficient for the LOD dataset (94% for the FLDA technique and 100% for ANNs approach). ANNs approach is more successful than the FLDA technique.
Silica spherules in Late Pleistocene‑Holocene glaciomarine sediments from the Ross Sea, Antarctica: insights into the formation and significance
Authors: Di Roberto Alessio , Del Carlo Paola , Bertagnini Antonella , Colizza Ester , Pompilio Massimo , Giglio Federico , Florindo Fabio
Published: September 2024

In this study, we investigate silica spherules with a diameter <1.25 mm from sediment cores retrieved from the northern Drygalski Trough, during the Italian Antarctic Research Programme (PNRA) expeditions in 1999 and 2002. In the past, these unique spherules have been a subject of interest due to their distinctive characteristics. Despite previous hypotheses on their origin, a comprehensive discussion on their formation mechanism and implications in marine sediments was lacking. Our analysis encompasses the depositional environment, morphology, internal texture, major element composition, and age determination through radiocarbon dating (14C) and 40Ar‑39Ar dating of spherule-containing sediments. By integrating our findings with a critical review of existing literature, we propose that spherules form by cyclical chemical precipitation of silica when silica‑rich freshwater mixed with seawater during extensive events of ice melting. We also tentatively suggest that these spherules possibly represent a proxy for significant meltwater production and discharge into the Antarctic Ocean. This research contributes to a better understanding of silica spherules in polar marine environments and their implications for past climate conditions.
Reinboldiella koreana sp. nov. (Ceramiales, Rhodophyta) is the correct name for the specimens previously known as Reinboldiella schmitziana in Korea
Authors: Kim Su Yeon , Choi Chang Geun , Yang Eun Chan , Kim Myung Sook
Published: September 2024

Epiphytic algae are important components of marine ecosystems. Despite the importance of epiphytic algae in marine ecosystems, our knowledge of these taxa is still limited. The marine red algal genus Reinboldiella, which is distributed mainly in the northwestern Pacific region, is characterized by tiny thalli that are epiphytic on various other red algae. Six species of the genus have been reported in Japan, Taiwan, and Korea. In this study, 50 Korean Reinboldiella specimens, previously known as Reinboldiella schmitziana, were collected from 11 localities and reexamined to verify their taxonomic status. We describe a new species, Reinboldiella koreana sp. nov., based on rbcL phylogeny and morphological observations. A total of four grateloupiacean species (Pachymeniopsis lanceolata, P. elliptica, Grateloupia turuturu, and G. asiatica) were identified as host species of R. koreana sp. nov. Due to the restricted host range of R. koreana sp. nov., a phylogenetic tree was reconstructed using the cox1 marker to confirm the co-phylogenetic relationships between the epiphytic algae and their grateloupiacean hosts. Two of the four cox1 haplotypes of R. koreana were found in different host species, regardless of which haplotype they were. It indicates that there are no co-phylogenetic relationships between R. koreana and host species.
A A pesquisa-formação em evidência
Authors: Nachtigall Cícero , Abrahão Maria Helena Menna Barreto
Published: September 2024

O presente trabalho integra uma pesquisa de doutorado em educação em desenvolvimento junto a uma universidade pública brasileira. A investigação opera com narrativas (auto)biográficas de sete futuros professores de matemática, produzidas a partir de um Seminário de Pesquisa-Formação e analisadas com base no método da compreensão cênica. O texto em tela busca repercutir uma das dimensões emergentes da análise, constituída segundo manifestações de afetos, incentivos, influências, escolhas e desafios relacionadas à opção pela profissão docente. O conhecimento produzido por meio da rememoração, reflexão e compreensão dos próprios percursos formativos reflete o potencial da escrita de si enquanto recurso indispensável à formação docente. A elaboração e apresentação dos memoriais de formação, a partilha e a cumplicidade do grupo ao longo do processo evidenciaram a relevância de espaços que permitam descortinar a singularidade dos percursos formativos, nos quais os futuros professores possam se reconhecer como autores/atores de suas próprias histórias.
Vulnerability and Vulnerance: Marginalization of Women in 1 Timothy 2:12-15
Authors: Panuntun Daniel Fajar , Oddeng Zulkifli
Published: September 2024

Did 1 Timothy 2:12-15 serve to marginalize women? From a feminist and vulnerability standpoint, we suggest reinterpreting the text with using Leo G. Perdue Biblical Theology concept. In terms of vulnerance, Paul restricts the role of women for the sake of the salvation of the Christian community in Ephesus under the shepherding of Timothy. From a perspective of vulnerability, women's restriction can be attributed to the issue of inequality, the hierarchical structure of control and subjugation by the wealthy during that era, and the susceptibility of women to be misled by heretical beliefs at the time. The passage 1 Timothy 2:12-15 provides insight into the cultural marginalization of women during that era. Therefore, the present-day Christian community must actively advocate for gender equality by addressing the underlying factors that contribute to the marginalization of women.
PERAN PEMIMPIN DALAM MENINGKATKAN KINERJA PEGAWAI KANTOR DI DINAS SOSIAL PROVINSI SUMATERA UTARA
Authors: Giawa Karcindi , Simon Jhon , Saragi Siswati
Published: September 2024

Dalam struktur organisasi pemerintah diindonesia, dinas sosial adalah unsur pelaksanaan tugas pemerintah daerah dibidang sosial berdasarkan asas otonomi dan tugas pembantuan, yang dipimpin oleh kepala dinas yang berkedudukan dibawah dan bertanggung jawab kepada walikota melalui sekertariat daerah. Perangkat yang dimaksud ialah terdiri dari kepala dinas yang dibantu oleh sekertariat yang meliputi pengelolaan administrasi umum, keuangan, dan penyususnan program serta fasilitas pengoordinasian penyusunan kebijakan dan pelaksanaan tugas kepala dinas yang memiliki 3(tiga) sub bagian antara lain : 1) sub bagian umum dan kepegawaian, 2) sub bagian keuangan, dan 3) sub bagian program, akuntabilitas dan akuntabilitas publik. Dalam melaksanakan tugas dan fungsinya peran pemimpin sangat penting dan mempengaruhi kinerja pegawainya.Metode penelitian yang digunakan oleh peneliti ialah metode deskriptif kualitatif, dengan teknik berupa wawancara, observasi, dan dokumentasi. Adapun hasil penelitian yang dapat peneliti ambil dari peran pemimpin dalam meningkatkan kinerja pegawai pada kantor dinas sosial provinsi sumatera utara adalah dalam menjalankan peran dan fungsinya sebagai seorang pemimpin terdapat 3 (tiga) indikator peranan seorang pemimpin yakni peranan bersifat pribadi, peranan membuat keputusan dan peranan bersifat informasi. Yang sudah cukup baik dijalankan mulai dari perencanaan, penggarahan, pengawasan, motivasi, pengendalian dan sikap. Sehingga dapat meningkatkan kinerja pegawainya walaupun hasil kinerjanya belum semaksimal mungkin. Disebabkan oleh, kurangnya kedisplinan dan kualitas kerja pegawai dalam menjalankan tugasnya. Peneliti melakukan wawancara dengan informan 1 sampai 7 dengan mendapat kesimpulan bahwa peran pemimpin yang dilakukan oleh kepala dinas sosial provsu sudah cukup baik. Namun, terdapat beberapa pegawai yang kurang disiplin dan kualitas kerja yang masih kurang yang disebabkan kurangnya ketegasan yang diberikan oleh pemimpin kepada pegawainya. Ini perlu menjadi perhatian instansi dan diharapkan mampu menggubahnya agar kinerja yang dilakukan oleh pegawai bisa semaksimal mungkin dan mewujudkan visi-misi yang telah ditetapkan.
Transporte de mercancías por carretera y transición ecológica socialmente justa: retos, avances y propuestas de mejora
Authors: Conde Colmenero Pilar
Published: September 2024

El transporte de mercancías por carretera debe transitar hacia un modelo económico que sea ecológico y, también, socialmente justo, favorecedor del empleo y el trabajo decentes. Este camino está sujeto a la Agenda 2030 para el Desarrollo Sostenible y a los sucesivos compromisos que España ha contraído durante el presente siglo. Los retos son enormes y urge acometerlos debido al apremiante avance del cambio climático y al deterioro de los derechos laborales; no obstante, los avances legales llevados a cabo en nuestro país en los últimos años son comedidos, mientras que las cuestiones pendientes de abordaje se acumulan a un ritmo vertiginoso. Este estudio analiza las características de la industria española de la logística y del transporte, para conocer las problemáticas sociolaborales del sector y, desde ahí, examinar las condiciones de trabajo y protección social del colectivo profesional emblemático de esta rama de actividad, los conductores y conductoras (del transporte nacional e internacional), independientemente de que ejerzan su actividad como asalariados, autónomos o asociados en cooperativas de transporte. El objetivo es proponer mejoras en las distintas vertientes de tutela laboral que merezcan especial atención (acceso a la profesión y capacitación, conciliación, seguridad y salud en el trabajo o Seguridad Social).
Measuring and monitoring tree cover and plant canopy height in Pune city, India
Authors: Das Pulakesh , Dey Sayantan , Balasubramanian Kanchana , Roy Parth Sarathi
Published: September 2024

Global datasets often fall short in estimating tree cover areas outside the forest tracts, particularly in urban areas. This limitation poses a challenge for accurately estimating tree cover outside forests (ToF) and understanding their contribution to ecosystem services. In the context of increasing population pressure and unsustainable urbanization in Indian cities, regional-level tree cover and canopy height estimations are crucial for evaluating the impact of ToF on various ecosystem services, including carbon sequestration, climate change adaptation, biodiversity hotspots, groundwater recharge, soil conservation, flood control, urban heat mitigation, and psychological and emotional well-being. This technical note outlines a rapid and cost-effective methodology for assessing tree canopy cover and height, specifically tailored for ToF estimation, offering a valuable tool for addressing these socio-urban environmental challenges and enabling sustainable land use planning.
Psychological Impact in Individuals with Monoclonal Gammopathy of Undetermined Significance and Smoldering Multiple Myeloma
Authors: Patel Tanvi H. , Bachu Ramya , Shrivastava Trilok , Alrawabdeh Jawad , Alzubi Marah , Hastings Jael , Dean Harold , Schinke Carolina , Thanendrarajan Sharmilan , Zangari Maurizio , Tricot Guido , Zhan Fenghuang , Shaughnessy John D , van Rhee Frits , Al Hadidi Samer
Published: September 2024

In our study of 246 newly diagnosed individuals with MGUS or SMM (115 MGUS, 131 SMM), we found that 19% reported anxiety, with no significant difference between the MGUS and SMM groups (22% vs. 17%). Those with a history of psychiatric disorders or belonging to certain racial groups were more likely to experience anxiety. Initial coping responses included religious coping, denial, frustration, irritability, and seeking social support. Given anxiety’s detrimental effects, our findings emphasize the importance of incorporating psychosocial assessments to optimize care for MGUS and SMM patients.
Accesibilidad en los espacios de la universidad y su incidencia en las relaciones de alteridad
Authors: Barrientos Roldán Natalia María
Published: September 2024

El presente estudio analiza la incidencia de la accesibilidad en los espacios sociales de una universidad de México sobre las relaciones de alteridad de que enfrentan los docentes con la PsDcuando el estudiante presenta alguna discapacidad. Se interpretaron pequeñas historias narradas por los docentes, desde la entrevista en profundidad, en comparación con la gran historia institucional, desde el performance en la investigación (el haikú y la fotografía). Como resultado, la universidad carece de un enfoque de accesibilidad consistente en sus instalaciones lo que causa el sentido de incertidumbre en las relaciones educativasextrañeza en el docente frente a la presencia del “otro diferente” en su clase. Por ello, la universidad es el reflejo de una sociedad que desaloja al “otro diferente”., y el profesor cuando enfrenta el reto personal de responder busca la manera de hacerse cargo de él.