bluuebunny/crossref_metadata_2025 huggingface dataset:
PLA-HPG based coating enhanced anti-biofilm and wound healing of Shikonin in MRSA-infected burn wound
Authors: Han Huiyu , Chen Lianheng , Liang Shu , Lü Jiawei , Wu Yashi , Wang Xiongjun , Xu Fei , Ge Lanlan , Xiao Lingyun
Published: August 2023

Burn wounds are susceptible to bacterial infections, including Methicillin-resistant Staphylococcus aureus (MRSA), which typically form biofilms and exhibit drug resistance. They also have specific feature of abundant exudate, necessitating frequent drug administration. Shikonin (SKN) has been reported to reverse MRSA drug resistance and possesses anti-biofilm and wound healing properties, however, it suffers from drawbacks of low solubility and instability. In this study, we developed PLA-HPG based bioadhesive nanoparticles SKN/BNP, which demonstrated a drug loading capacity of about 3.6%, and exhibited sustained-release behavior of SKN. The aldehyde groups present on the surface of BNP improved the local adhesion of SKN/BNP both in vitro and in vivo, thereby reducing the frequency of drug dosing in exudate-rich burn wounds. BNP alone enhanced proliferation and migration of the fibroblast, while SKN/BNP promoted fibroblast proliferation and migration as well as angiogenesis. Due to its bioadhesive property, BNP directly interacted with biofilm and enhanced the efficacy of SKN against MRSA biofilm in vitro. In a mouse model of MRSA-infected burn wounds, SKN/BNP demonstrated improved anti-biofilm and wound healing efficiency. Overall, our findings suggest that SKN/BNP holds great promise as a novel and effective treatment option for clinical applications in MRSA-infected burn wounds.
Multi-list interfaces for recommender systems: survey and future directions
Authors: Loepp Benedikt
Published: August 2023

For a long time, recommender systems presented their results in the form of simple item lists. In recent years, however, multi-list interfaces have become the de-facto standard in industry, presenting users with numerous collections of recommendations, one below the other, each containing items with common characteristics. Netflix's interface, for instance, shows movies from certain genres, new releases, and lists of curated content. Spotify recommends new songs and albums, podcasts on specific topics, and what similar users are listening to. Despite their popularity, research on these so-called “carousels” is still limited. Few authors have investigated how to simulate the user behavior and how to optimize the recommendation process accordingly. The number of studies involving users is even smaller, with sometimes conflicting results. Consequently, little is known about how to design carousel-based interfaces for achieving the best user experience. This mini review aims to organize the existing knowledge and outlines directions that may improve the multi-list presentation of recommendations in the future.
Impact of inverter-based resources on transmission line relaying -part II: power swing protection
Authors: Jalilian Amin , Robinson Duane A.
Published: August 2023

The power swing characteristic of transmission lines (TLs) can be affected by the large-scale integration of inverter-based resources (IBRs), resulting in the maloperation of the legacy power swing blocking (PSB) and out-of-step tripping (OST) functions. This paper presents a brief review of power swing phenomena and the impact on power swing protection functions. In this regard, the impact of IBR integration of type-III, and type-IV wind turbine generation (WTG) on legacy power swing protection functions has been scrutinized. To do so, the performance of impedance-based PSB and OST functions during the IBR integration has been investigated via comprehensive simulation studies. The results show that under a system contingency and high IBR penetration, depending on the IBR technology, the system experiences frequency oscillations and swinging impedance trajectories which are different from those from synchronous generators, such that the reliable operation of the legacy PSB and OST functions can be jeopardized. Moreover, during power swing phenomena, the simulation results have found that the security of distance protection cannot be guaranteed and the fault ride-through requirements cannot be maintained when a high share of IBRs have been integrated.
A photovoltaic parameter identification method based on Pontogammarus maeoticus swarm optimization
Authors: Chen Ling , Han Wei , Shi Yang , Zhang Jingwei , Cao Shang
Published: August 2023

Currently, the improvement of model parameter extraction accuracy is essential to research photovoltaic (PV) fields. In this study, a model parameter identification based on Pontogammarus maeoticus swarm optimization (PMSO) is proposed. The PMSO is used for parameter identification of mathematical models for PV modules. In the PMSO algorithm, by giving the ability of free exploration to particles that are far away from the optimal solution, the search scope is expanded to avoid falling into the local optimum. Besides, the local search for each Gammarus has a better convergence for PV parameter identification. Therefore, the accuracy of parameter identification for modeling PV modules is improved. The feasibility and superiority of the proposed method are verified by measured I-V characteristics of the PV array. The experimental results and error analysis verify that when compared with the conventional meta-heuristic algorithms, the proposed method achieves higher modeling accuracy. The proposed PMSO algorithm is suitable for engineering application of parameter identification and modeling of PV modules.
Antiviral mechanisms of two broad-spectrum monoclonal antibodies for rabies prophylaxis and therapy
Authors: Zorzan Maira , Castellan Martina , Gasparotto Matteo , Dias de Melo Guilherme , Zecchin Barbara , Leopardi Stefania , Chen Alex , Rosato Antonio , Angelini Alessandro , Bourhy Hervé , Corti Davide , Cendron Laura , De Benedictis Paola
Published: August 2023

Rabies is an acute and lethal encephalomyelitis caused by lyssaviruses, among which rabies virus (RABV) is the most prevalent and important for public health. Although preventable through the post-exposure administration of rabies vaccine and immunoglobulins (RIGs), the disease is almost invariably fatal since the onset of clinical signs. Two human neutralizing monoclonal antibodies (mAbs), RVC20 and RVC58, have been shown to be effective in treating symptomatic rabies. To better understand how these mAbs work, we conducted structural modeling and in vitro assays to analyze their mechanisms of action, including their ability to mediate Fc-dependent effector functions. Our results indicate that both RVC20 and RVC58 recognize and lock the RABV-G protein in its pre-fusion conformation. RVC58 was shown to neutralize more potently the extra-cellular virus, while RVC20 mainly acts by reducing viral spreading from infected cells. Importantly, RVC20 was more effective in promoting effector functions compared to RVC58 and 17C7-RAB1 mAbs, the latter of which is approved for human rabies post-exposure treatment. These results provide valuable insights into the multiple mechanisms of action of RVC20 and RVC58 mAbs, offering relevant information for the development of these mAbs as treatment for human rabies.
Case Report: Molecular and microenvironment change upon midostaurin treatment in mast cell leukemia at single-cell level
Authors: Liu Meng-Ke , Liu Feng , Dai Yu-Ting , Weng Xiang-Qin , Cheng Li-Li , Fan Li-Quan , Liu Han , Jiang Lu , Sun Xiao-Jian , Fang Hai , Wang Li , Zhao Wei-Li
Published: August 2023

Mast cell leukemia is a rare and aggressive disease, predominantly with KIT D816V mutation. With poor response to conventional poly-chemotherapy, mast cell leukemia responded to the midostaurin treatment with a 50% overall response rate (ORR), but complete remission rate is approximately 0%. Therefore, the potential mechanisms of midostaurin resistance and the exact impacts of midostaurin on both gene expression profile and mast cell leukemia microenvironment in vivo are essential for design tailored combination therapy targeting both the tumor cells and the tumor microenvironment. Here we report a 59-year-old male mast cell leukemia patient with KIT F522C mutation treated with midostaurin. Single-cell sequencing of peripheral blood and whole exome sequencing (WES) of bone marrow were performed before and 10 months after midostaurin treatment. In accordance with the clinical response, compared to the pretreatment aberration, the decline of mast cells and increase of T-, NK, B-cells in peripheral blood, and the decrease of the KIT F522C mutation burden in bone marrow were observed. Meanwhile, the emergence of RUNX1 mutation, upregulations of genes expression (RPS27A, RPS6, UBA52, RACK1) on tumor cells, and increased frequencies of T and NK cells with TIGIT, CTLA4, and LAG3 expression were observed after midostaurin treatment, predicting the disease progression of this patient. As far as we know, this is the first case reporting the clinical, immunological, and molecular changes in mast cell leukemia patients before and after midostaurin treatment, illustrating the in vivo mechanisms of midostaurin resistance in mast cell leukemia, providing important clues to develop a sequential option to circumvent tumor progression after targeting oncogene addiction and prolong patients’ survival.
Unraveling the transcriptome-based network of tfh cells in primary sjogren syndrome: insights from a systems biology approach
Authors: Luo Danyang , Li Lei , Yang Yi , Ye Yulin , Hu Jiawei , Zong Yuan , Zhao Jiawen , Gao Yiming , Xu Haimin , Li Ning , Xie Yinyin , Jiang Liting
Published: August 2023

Background

Primary Sjogren Syndrome (pSS) is an autoimmune disease characterized by immune cell infiltration. While the presence of follicular T helper (Tfh) cells in the glandular microenvironment has been observed, their biological functions and clinical significance remain poorly understood.

Methods

We enrolled a total of 106 patients with pSS and 46 patients without pSS for this study. Clinical data and labial salivary gland (LSG) biopsies were collected from all participants. Histological staining was performed to assess the distribution of Tfh cells and B cells. Transcriptome analysis using RNA-sequencing (RNA-seq) was conducted on 56 patients with pSS and 26 patients without pSS to uncover the underlying molecular mechanisms of Tfh cells. To categorize patients, we employed the single-sample gene set enrichment analysis (ssGSEA) algorithm, dividing them into low- and high-Tfh groups. We then utilized gene set enrichment analysis (GSEA), weighted gene co-expression network analysis (WGCNA), and deconvolution tools to explore functional and immune infiltration differences between the low- and high-Tfh groups.

Results

Patients with pSS had a higher positive rate of the antinuclear antibody (ANA), anti-Ro52, anti-SSA, anti-SSB and hypergammaglobulinaemia and higher levels of serum IgG compared to the non-pSS. Histopathologic analyses revealed the presence of Tfh cells (CD4+CXCR5+ICOS+) in germinal centers (GC) within the labial glands of pSS patients. GSEA, WGCNA, and correlation analysis indicated that the high-Tfh group was associated with an immune response related to virus-mediated IFN response and metabolic processes, primarily characterized by hypoxia, elevated glycolysis, and oxidative phosphorylation levels. In pSS, most immune cell types exhibited significantly higher infiltration levels in the high-Tfh group compared to the low-Tfh group. Additionally, patients in the Tfh-high group demonstrated a higher positive rate of the ANA, rheumatoid factor (RF), and hypergammaglobulinaemia, as well as higher serum IgG levels.

Conclusion

Our study suggests that Tfh cells may play a crucial role in the pathogenesis of pSS and could serve as potential therapeutic targets in pSS patients.
Evaluation of an automated microscope using machine learning for the detection of malaria in travelers returned to the UK
Authors: Rees-Channer Roxanne R. , Bachman Christine M. , Grignard Lynn , Gatton Michelle L. , Burkot Stephen , Horning Matthew P. , Delahunt Charles B. , Hu Liming , Mehanian Courosh , Thompson Clay M. , Woods Katherine , Lansdell Paul , Shah Sonal , Chiodini Peter L.
Published: August 2023

Introduction

Light microscopy remains a standard method for detection of malaria parasites in clinical cases but training to expert level requires considerable time. Moreover, excessive workflow causes fatigue and can impact performance. An automated microscopy tool could aid in clinics with limited access to highly skilled microscopists, where case numbers are excessive, or in multi-site studies where consistency is essential. The EasyScan GO is an automated scanning microscope combined with machine learning software designed to detect malaria parasites in field-prepared Giemsa-stained blood films. This study evaluates the ability of the EasyScan GO to detect, quantify and identify the species of parasite present in blood films compared with expert light microscopy.

Methods

Travelers returning to the UK and testing positive for malaria were screened for eligibility and enrolled. Blood samples from enrolled participants were used to make Giemsa-stained smears assessed by expert light microscopy and the EasyScan GO to determine parasite density and species. Blood samples were also assessed by PCR to confirm parasite density and species present and resolve discrepancy between manual microscopy and the EasyScan GO.

Results

When compared to light microscopy, the EasyScan GO exhibited a sensitivity of 88% (95% CI: 80-93%) and a specificity of 89% (95% CI: 87-91%). Of the 99 samples labelled positive by both, manual microscopy identified 87 as Plasmodium falciparum (Pf) and 12 as non-Pf. The EasyScan GO correctly reported Pf for 86 of the 87 Pf samples and non-Pf for 11 of 12 non-Pf samples. However, it failed to distinguish between non-Pf species, reporting all as P. vivax. The EasyScan GO calculated parasite densities were within +/-25% of light microscopy densities for 33% of samples between 200 and 2000 p/µL, falling short of WHO level 1 (expert) manual microscopy competency (50% of samples should be within +/-25% of the true parasitemia).

Discussion

This study shows that the EasyScan GO can be proficient in detecting malaria parasites in Giemsa-stained blood films relative to expert light microscopy and accurately distinguish between Pf and non-Pf species. Performance at low parasite densities, distinguishing between non-Pf species and accurate quantitation of parasitemia require further development and evaluation.
A single infusion of intravenous lidocaine for primary headaches and trigeminal neuralgia: a retrospective analysis
Authors: Mullins C. F. , Fuccaro M. , Pang D. , Min L. , Andreou A. P. , Lambru G.
Published: August 2023

Introduction

Intravenous (IV) lidocaine has been used as a transitional treatment in headache and facial pain conditions, typically as an inpatient infusion over several days, which is costly and may increase the risk of adverse effects. Here we report on our experience using a single one-hour IV lidocaine infusion in an outpatient day-case setting for the management of refractory primary headache disorders with facial pain and trigeminal neuralgia.

Methods

This is a retrospective, single-center analysis on patients with medically refractory headache with facial pain and trigeminal neuralgia who were treated with IV lidocaine between March 2018 and July 2022. Lidocaine 5 mg.kg−1 in 60 mL saline was administered over 1 h, followed by an observation period of 30 min. Patients were considered responders if they reported reduction in pain intensity and/or headache frequency of 50% or greater. Duration of response was defined as short-term (< 2 weeks), medium-term (2–4 weeks) and long-term (> 4 weeks).

Results

Forty infusions were administered to 15 patients with trigeminal autonomic cephalalgias (n = 9), chronic migraine (n = 3) and trigeminal neuralgia (n = 3). Twelve patients were considered responders (80%), eight of whom were complete responders (100% pain freedom). The average duration of the treatment effect for each participant was 9.5 weeks (range 1–22 weeks). Six out of 15 patients reported mild and self-limiting side effects (40%).

Conclusion

A single infusion of IV lidocaine might be an effective and safe transitional treatment in refractory headache conditions with facial pain and trigeminal neuralgia. The sustained effect of repeated treatment cycles in some patients may suggest a role as long-term preventive therapy in some patients.
Vascular risk factors for idiopathic normal pressure hydrocephalus: a systematic review and meta-analysis
Authors: Cai Hanlin , Yang Feng , Gao Hui , Huang Keru , Qin Linyuan , Wang Ruihan , Liu Yi , Zhou Liangxue , Hao Zilong , Zhou Dong , Chen Qin
Published: August 2023

Objective

Idiopathic normal-pressure hydrocephalus (iNPH) is a treatable cause of dementia; however, its etiology and pathogenesis remain poorly understood. The objective of this study was to investigate the prevalence and impact of vascular risk factors in patients with iNPH compared to a control cohort to better understand the potential mechanisms and preventive measures.

Methods

We systematically searched PubMed, Web of Science, Embase, and the Cochrane Library (from inception to December 20, 2022) for studies reporting vascular risk factors for the development of iNPH. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using random-effects models.

Results

After screening 1,462 articles, 11 case-control studies comprising 1,048 patients with iNPH and 79,668 cognitively unimpaired controls were included in the meta-analysis. Our data showed that hypertension (N = 991, OR = 2.30, 95% CI 1.64 to 3.23, I2= 64.0%), diabetes mellitus (DM) (N = 985, OR = 3.12, 95% CI 2.29 to 4.27, I2= 44.0%), coronary heart disease (CHD; N = 880, OR = 2.34, 95% CI 1.33 to 4.12, I2= 83.1%), and peripheral vascular disease (N = 172, OR = 2.77, 95% CI 1.50 to 5.13, I2= 0.0%) increased the risk for iNPH, while overweight was a possible factor (N = 225, OR = 2.01, 95% CI 1.34 to 3.04, I2= 0.0%) based on the sensitivity analysis. Smoking and alcohol consumption were not associated with iNPH.

Conclusions

Our study suggested that hypertension, DM, CHD, peripheral vascular disease, and overweight were associated with iNPH. These factors might be involved in the pathophysiological mechanisms promoting iNPH. These findings require further investigation in future studies.

Systematic review registration

https://www.crd.york.ac.uk/PROSPERO/, CRD42022383004.
Bilateral globus pallidus interna deep brain stimulation in the treatment of mixed cerebral palsy in ataxia with dyskinesia: a case report
Authors: Chang Lei , Luo Bei , Dong Wenwen , Qiu Chang , Lu Yue , Sun Jian , Yan Jiuqi , Zhang Wenbin , Yan Jun
Published: August 2023

Background

Cerebral palsy (CP), a complex syndrome with multiple etiologies, is characterized by a range of movement disorders within the hypokinetic and hyperkinetic spectrum (dystonia or choreoathetosis). CP is often accompanied by neurological and psychiatric signs, such as spasticity, ataxia, and cognitive disorders. Although current treatment options for CP include pharmacological interventions, rehabilitation programs, and spasticity relief surgery, their effectiveness remains limited. Deep brain stimulation (DBS) has demonstrated significant effectiveness in managing dyskinesia; however, its potential therapeutic effect on CP remains determined.

Methods

We present a case of a 44-year-old Asian female who was born as a twin with neonatal ischemic–hypoxic encephalopathy due to prolonged labor and delivery. She was diagnosed with CP at the age of 1 year. The patient exhibited delayed development compared to her peers and presented with various symptoms, including slurred speech, broad-based gait, horseshoe inversion of the right lower extremity, involuntary shaking of the upper extremities bilaterally, and hypotonia and showed no improvement with levodopa therapy. Two years ago, she developed progressive head tremors, which worsened during periods of tension and improved during sleep. As medical treatments proved ineffective and there were no contraindications to surgery, we performed bilateral globus pallidus interna DBS (GPi-DBS) to alleviate her motor dysfunction.

Results

Following a 6-month follow-up, the patient demonstrated significant improvements in motor symptoms, including head and limb tremors and dystonia. In addition, significant improvement was observed in her overall psychological well-being, as evidenced by reduced anxiety and depression levels.

Conclusion

DBS is an effective treatment for dyskinesia symptoms associated with CP in adults. Moreover, its effectiveness may continue to increase over time.
ACE2 overexpression in corticotropin-releasing-hormone cells offers protection against pulmonary hypertension
Authors: Oliveira Aline C. , Karas Marianthi M. , Alves Matthew , He Jacky , de Kloet Annette D. , Krause Eric G. , Richards Elaine M. , Bryant Andrew J. , Raizada Mohan K.
Published: August 2023

Background

Pulmonary hypertension (PH), characterized by elevated pulmonary pressure and right heart failure, is a systemic disease involving inappropriate sympathetic activation and an impaired gut-brain-lung axis. Global overexpression of angiotensin converting enzyme 2 (ACE2), a cardiopulmonary protective enzyme of the renin-angiotensin system, attenuates PH induced by chronic hypoxia. Neurons within the paraventricular nucleus of the hypothalamus (PVN) that synthesize corticotropin-releasing hormone (CRH) are activated by stressors, like hypoxia, and this activation augments sympathetic outflow to cardiovascular tissues. These data coupled with our observations that ACE2 overexpression in CRH cells (CRH-ACE2KI mice) decreases anxiety-like behavior via suppression of hypothalamic–pituitary–adrenal (HPA) axis activity by decreasing CRH synthesis, led us to hypothesize that selective ACE2 overexpression in CRH neurons would protect against hypoxia-induced PH.

Methods

CRH-ACE2KI and WT male and female mice were exposed to chronic hypoxia (10%O2) or normoxia (21%O2) for 4 weeks in a ventilated chamber with continuous monitoring of oxygen and carbon dioxide concentrations (n = 7–10/group). Pulmonary hemodynamics were measured with Millar pressure catheters then tissues were collected for histological analyses.

Results

Chronic hypoxia induced a significant increase (36.4%) in right ventricular (RV) systolic pressure (RVSP) in WT mice, which was not observed in CRH-ACE2KI mice. No significant differences in RVSP were observed between male and female mice in any of the groups.

Conclusion

Overexpression of ACE2 in CRH cells was protective against hypoxia-induced PH. Since the majority of expression of CRH is in brain nuclei such as paraventricular nucleus of the hypothalamus (PVN) and/or central nucleus of the amygdala (CeA) these data indicate that the protective effects of ACE2 are, at least in part, centrally mediated. This contributes to the systemic nature of PH disease and that CRH neurons may play an important role in PH.
Neuroimaging in acute infection-triggered encephalopathy syndromes
Authors: Takanashi Jun-ichi , Uetani Hiroyuki
Published: August 2023

Acute encephalopathy associated with infectious diseases occurs frequently in Japanese children (400–700 children/year) and is the most common in infants aged 0–3 years. Acute encephalopathy is classified into several clinicoradiological syndromes; acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is the most common subtype, followed by clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) and acute necrotizing encephalopathy (ANE). Neuroimaging, especially magnetic resonance imaging (MRI), is useful for the diagnosis, assessment of treatment efficacy, and evaluation of the pathophysiology of encephalopathy syndromes. MRI findings essential for diagnosis include delayed subcortical reduced diffusion (bright tree appearance) for AESD, reversible splenial lesions with homogeneously reduced diffusion for MERS, and symmetric hemorrhagic thalamic lesions for ANE. We reviewed several MRI techniques that have been applied in recent years, including diffusion-weighted imaging for the characterization of cerebral edema, arterial spin labeling for evaluating cerebral perfusion, and magnetic resonance spectroscopy for evaluating metabolic abnormality.
Truck model recognition for an automatic overload detection system based on the improved MMAL-Net
Authors: Sun Jiachen , Su Jin , Yan Zhenhao , Gao Zenggui , Sun Yanning , Liu Lilan
Published: August 2023

Efficient and reliable transportation of goods through trucks is crucial for road logistics. However, the overloading of trucks poses serious challenges to road infrastructure and traffic safety. Detecting and preventing truck overloading is of utmost importance for maintaining road conditions and ensuring the safety of both road users and goods transported. This paper introduces a novel method for detecting truck overloading. The method utilizes the improved MMAL-Net for truck model recognition. Vehicle identification involves using frontal and side truck images, while APPM is applied for local segmentation of the side image to recognize individual parts. The proposed method analyzes the captured images to precisely identify the models of trucks passing through automatic weighing stations on the highway. The improved MMAL-Net achieved an accuracy of 95.03% on the competitive benchmark dataset, Stanford Cars, demonstrating its superiority over other established methods. Furthermore, our method also demonstrated outstanding performance on a small-scale dataset. In our experimental evaluation, our method achieved a recognition accuracy of 85% when the training set consisted of 20 sets of photos, and it reached 100% as the training set gradually increased to 50 sets of samples. Through the integration of this recognition system with weight data obtained from weighing stations and license plates information, the method enables real-time assessment of truck overloading. The implementation of the proposed method is of vital importance for multiple aspects related to road traffic safety.
Food exchange list based on macronutrients: adapted for the Ecuadorian population
Authors: Chisaguano-Tonato Aida Maribel , Herrera-Fontana María Elisa , Vayas-Rodriguez Gabriela
Published: August 2023

Background

Food exchange lists allow health professionals to generate healthy eating plans adapted to individual or population needs. The objective of this study was to develop the first food exchange list based on the macronutrients and energy provided by the various food groups of the Ecuadorian diet.

Methods

The list of Ecuadorian food exchanges was constructed by going through the following phases: (1) Selection of household measurements; (2) Selection of tables and databases of the nutritional composition of food items; (3) Definition of food groups and quantities; (4) Determination of the average energy and macronutrient values of each group; and (5) Photographic record. For the definition of food quantities, statistical criteria were applied according to a standard deviation of ±2SD; thus, for carbohydrates: ±5 g, total fat: ±2 g, and protein: ±3 g. To ensure the inclusion of the food items in the groups, a coefficient of variation of less than 30% and a Z value of ±2 were also considered.

Results

The list of food exchanges is presented with eight general groups according to the predominant nutrient (carbohydrates, proteins, or fats), and, where necessary, subgroups are included according to the second predominant nutrient. The list includes 404 food items with their photographic record, represented by their net weights and corresponding household measurement. All food items met the statistical criteria that help to reduce the variability of the nutritional composition of the food items in each group.

Conclusion

This is the first list of Ecuadorian food exchanges based on statistical criteria. It represents a novel tool for public health professionals as well as researchers. Resulting healthier eating plans may improve daily dietetic practice, facilitate better clinical trial designs and help establish guidelines according to Ecuador’s cultural and dietary patterns. The described methodology can further be used to develop other food exchanges lists for patients with specific nutritional requirements.
A scientometric analysis of research trends on targeting mTOR in breast cancer from 2012 to 2022
Authors: Zhang Xizhou , Wu Jinyao , Yang Qiuping , Tian Huiting , Chen Lingzhi , Zheng Daitian , Ji Zeqi , Cai Jiehui , Chen Yexi , Li Zhiyang
Published: August 2023

Over the past decade, thousands of articles have been published on the mechanistic target of rapamycin (mTOR) and its role in breast cancer. However, the variability and heterogeneity of academic data may impact the acquisition of published research information. Due to the large number, heterogeneity, and varying quality of publications related to mTOR and breast cancer, sorting out the present state of the research in this area is critical for both researchers and clinicians. Therefore, scientometric techniques and visualization tools were employed to analyze the large number of bibliographic metadata related to the research area of mTOR and breast cancer. The features of relevant publications were searched from 2012 to 2022 to evaluate the present status of research and the evolution of research hotspots in this particular field. Web of Science was utilized to extract all relevant publications from 2012 to 2022. Subsequently, Biblioshiny and VOSviewer were utilized to obtain data on the most productive countries, authors, and institutions, annual publications and citations, the most influential journals and articles, and the most frequently occurring keywords. In total, 1,471 publications were retrieved, comprising 1,167 original articles and 304 reviews. There was a significant rise in publications between 2015 and 2018, followed by a sharp decline in 2019 and a rebound since then. The publication with the highest number of citations was a 2012 review authored by Baselga et al. The United States had the highest number of publications, citations and connections among all countries. Oncotarget had the highest number of published articles among all the journals, and José Baselga had the strongest links with other authors. Excluding the search topics, the most frequently used words were “expression” (n = 297), “growth” (n = 228), “activation” (n = 223), “pathway” (n = 205), and “apoptosis” (n = 195). mTOR is crucially involved in breast cancer pathogenesis, but its exact mechanism of action remains controversial and warrants further investigation. The scientometric analysis provides a distinct overview of the existing state of research and highlights the topical issues that deserve further exploration.
Effects of WeChat follow-up management on the psychological distress, care burden, and quality of life of parents of infants with bronchopulmonary dysplasia: a retrospective cohort study
Authors: Shi Zhong-Shan , Wang Xin-Bing , Wang Ming-Cong , Zeng Yan-Yan
Published: August 2023

Objective

The objective was to explore the impact of WeChat follow-up management on the psychological distress, care burden, and quality of life of parents of infants with bronchopulmonary dysplasia (BPD) receiving in-home care.

Methods

This was a retrospective cohort study. A total of 101 parents of infants with BPD who were followed up from January 2016 to January 2022 were included in this study. According to different follow-up methods, these patients were classified into the WeChat group and the routine group. The Depression, Anxiety, and Stress Scale-21 (DASS-21), Zarit Caregiver Burden Interview (ZBI), and WHOQOL-BREF were used. The data on the psychological distress, care burden, and quality of life of the parents in the two groups were analyzed and compared at discharge and at the 3-month follow-up.

Results

There was no significant difference in the DASS-21 and ZBI scores at discharge between the parents in the two groups. During the 3-month follow-up, the scores of the DASS-21 anxiety and stress subscale and the ZBI of parents in the WeChat group were significantly lower than those of parents in the routine group (P < 0.05); however, there was no significant difference in the depression subscale score between the two groups (P > 0.05). A comparison of the WHOQOL-BREF score between the two groups showed that the total quality of life score in the WeChat group was significantly higher than that in the routine group (P < 0.05). The scores of the psychological and social relationship fields in the WeChat group were significantly higher than those in the routine group (P < 0.05). The incidence of adverse events during follow-up was significantly lower in the WeChat group than in the routine group (P < 0.05).

Conclusion

WeChat follow-up management is helpful to decrease the anxiety and stress, reduce the care burden, and improve the quality of life of parents of infants with BPD receiving in-home care.
Research progress of optoelectronic devices based on diamond materials
Authors: Fei Houzhi , Sang Dandan , Zou Liangrui , Ge Shunhao , Yao Yu , Fan Jianchao , Wang Cong , Wang Qinglin
Published: August 2023

Diamond has a variety of unique characteristics, including integrates mechanics, electricity, heat, optics and other excellent properties, so that it is widely focus on the field of high and new technology, especially in the optoelectronic technology. Because diamond has the characteristics of high thermal conductivity, high breakdown field (10 mV/cm), high electron and hole mobility, it has a wide application prospect in high temperature, high power and high frequency photoelectric equipment. The wide bandgap (5.47 eV) makes diamond an ideal material in ultraviolet detectors (UV). Its high carrier mobility and breakdown field strength make it an ideal choice for field emission materials, which are expected to be used in high-power electronic devices in the next few years. At the same time, in addition to high hardness, it also has various of excellent physical properties, such as low coefficient of thermal expansion, low coefficient of friction, high acoustic propagation speed and high optical transmittance, so that it has broad application prospects in many fields such as machining, microelectronic devices, optical windows and surface coatings. In addition, diamond also has a high exciton binding energy (80 meV), which plays an important development in deep ultraviolet and high-energy particle detectors. In this article, the latest progress in the application of diamond-based optoelectronic devices is reviewed. A variety of advanced devices and physical phenomena are considered, for example, sensors, transistors, memory, Light-emitting diode (LEDs), ultraviolet detectors and field emission. This review will provide a new idea to promote the development of photoelectric applications based on diamond structure.
Identification and validation of potential hypoxia-related genes associated with coronary artery disease
Authors: Jin Yuqing , Ren Weiyan , Liu Jiayi , Tang Xuejiao , Shi Xinrui , Pan Dongchen , Hou Lianguo , Yang Lei
Published: August 2023

Introduction: Coronary artery disease (CAD) is one of the most life-threatening cardiovascular emergencies with high mortality and morbidity. Increasing evidence has demonstrated that the degree of hypoxia is closely associated with the development and survival outcomes of CAD patients. However, the role of hypoxia in CAD has not been elucidated.

Methods: Based on the GSE113079 microarray dataset and the hypoxia-associated gene collection, differential analysis, machine learning, and validation of the screened hub genes were carried out.

Results: In this study, 54 differentially expressed hypoxia-related genes (DE-HRGs), and then 4 hub signature genes (ADM, PPFIA4, FAM162A, and TPBG) were identified based on microarray datasets GSE113079 which including of 93 CAD patients and 48 healthy controls and hypoxia-related gene set. Then, 4 hub genes were also validated in other three CAD related microarray datasets. Through GO and KEGG pathway enrichment analyses, we found three upregulated hub genes (ADM, PPFIA4, TPBG) were strongly correlated with differentially expressed metabolic genes and all the 4 hub genes were mainly enriched in many immune-related biological processes and pathways in CAD. Additionally, 10 immune cell types were found significantly different between the CAD and control groups, especially CD8 T cells, which were apparently essential in cardiovascular disease by immune cell infiltration analysis. Furthermore, we compared the expression of 4 hub genes in 15 cell subtypes in CAD coronary lesions and found that ADM, FAM162A and TPBG were all expressed at higher levels in endothelial cells by single-cell sequencing analysis.

Discussion: The study identified four hypoxia genes associated with coronary heart disease. The findings provide more insights into the hypoxia landscape and, potentially, the therapeutic targets of CAD.
Identification of sources of DIF using covariates in patient-reported outcome measures: a simulation study comparing two approaches based on Rasch family models
Authors: Dubuy Yseulys , Hardouin Jean-Benoit , Blanchin Myriam , Sébille Véronique
Published: August 2023

When analyzing patient-reported outcome (PRO) data, sources of differential item functioning (DIF) can be multiple and there may be more than one covariate of interest. Hence, it could be of great interest to disentangle their effects. Yet, in the literature on PRO measures, there are many studies where DIF detection is applied separately and independently for each covariate under examination. With such an approach, the covariates under investigation are not introduced together in the analysis, preventing from simultaneously studying their potential DIF effects on the questionnaire items. One issue, among others, is that it may lead to the detection of false-positive effects when covariates are correlated. To overcome this issue, we developed two new algorithms (namely ROSALI-DIF FORWARD and ROSALI-DIF BACKWARD). Our aim was to obtain an iterative item-by-item DIF detection method based on Rasch family models that enable to adjust group comparisons for DIF in presence of two binary covariates. Both algorithms were evaluated through a simulation study under various conditions aiming to be representative of health research contexts. The performance of the algorithms was assessed using: (i) the rates of false and correct detection of DIF, (ii) the DIF size and form recovery, and (iii) the bias in the latent variable level estimation. We compared the performance of the ROSALI-DIF algorithms to the one of another approach based on likelihood penalization. For both algorithms, the rate of false detection of DIF was close to 5%. The DIF size and form influenced the rates of correct detection of DIF. Rates of correct detection was higher with increasing DIF size. Besides, the algorithm fairly identified homogeneous differences in the item threshold parameters, but had more difficulties identifying non-homogeneous differences. Over all, the ROSALI-DIF algorithms performed better than the penalized likelihood approach. Integrating several covariates during the DIF detection process may allow a better assessment and understanding of DIF. This study provides valuable insights regarding the performance of different approaches that could be undertaken to fulfill this aim.
False memory in between-language conditions: a brief review on the effect of encoding and retrieving in different languages
Authors: Beato Maria Soledad , Suarez Mar , Cadavid Sara , Albuquerque Pedro B.
Published: August 2023

False memories have been extensively investigated over the past few decades using the Deese/Roediger-McDermott (DRM) paradigm. In this paradigm, participants study lists of words associatively related to a non-presented critical lure. During a memory test, these critical lures are falsely recalled or recognized. Most studies have focused on false memories that arise when both encoding and retrieval are conducted in the same language (i.e., within-language conditions), which is typically the participant’s native or first language (L1). However, much less is known about false memories when critical lures appear in the memory test in a different language than the studied lists (i.e., between-language conditions), being one of them the participant’s second language (L2). The main objective of this exhaustive review was to provide an overview of the current state of research on false recognition using the DRM paradigm in between-language conditions, where languages are switched between encoding and retrieval (i.e., L1L2 versus L2L1). The results revealed a language dominance effect in between-language false memories. In other words, false recognition rates were dependent on the study language, with a trend toward higher false recognition when words were enconded in the L1 (L1L2) compared to when words were encoded in the L2 (L2L1). This review enhances our understanding of how studying words in a first or second language affects false memory in the DRM paradigm, emphasizing the significance of investigating false memory in second language speakers and the necessity for further research in the field.
Counseling and support services for healthcare workers in German university hospitals during the pandemic—descriptive results of a Germany-wide cross-sectional survey
Authors: Diehl Elisabeth , Mülder Lina Marie , Imm Carolin , Kegel Peter , Tolksdorf Marian , Wiegand Hauke Felix , Röthke Nikolaus , Tüscher Oliver , Lieb Klaus , Walter Henrik , Liebe Susanne , Maicher Birgit , Hellwig Sabine , Adorjan Kristina , Unterecker Stefan , Beutel Manfred , Rose Dirk-Matthias
Published: August 2023

Background

Due to the SARS-CoV-2 pandemic, healthcare workers (HCWs) are experiencing tremendous levels of emotional and physical stress. Hospitals are trying to help personnel cope with work-related pressure. The aim of this study was to assess HCWs’ awareness and utilization of counseling and support services during the pandemic, HCWs’ unmet counseling and support needs, and the type and content of these services.

Methods

A cross-sectional online survey was conducted from January to June 2021 through the German national research organization Network University Medicine (NUM). All participating hospitals (6 in total) were asked to inform their employees about the study.

Results

A total of 1,495 HCWs were included in the analysis. Of these, 42.8% (n = 637) were frontline HCWs (who had contact with COVID-19 patients), 23.1% (n = 344) were second-line HCWs (who only had contact with non-COVID-19 patients) and 34.1% (n = 508) had no contact with any patients. Participating hospitals offer various counseling and support services for their staff. The percentage of respondents who were unaware of available counseling and support services ranged from 5.0 to 42.0%. Depending on the type of counseling and support services, 23.0–53.6% of the respondents indicated that counseling and support services were provided but not used, while 1.7–11.6% indicated that, despite the need for them, such services were not available. HCWs’ overall satisfaction with the provided counseling and support services and their unmet support needs differed by patient contact: Frontline HCWs reported more unmet needs for counseling and support than second-line HCWs, while second-line HCWs reported more unmet needs than HCWs without patient contact.

Conclusion

The results indicate that hospitals should make more efforts to inform HCWs about available counseling and support services. Hospitals could also create networks where HCWs could share information about the type and content of services and their experiences with various counseling and support services. These steps would enable hospitals to respond more quickly and effectively to the problems facing HCWs during pandemics.
Analysis of the factors influencing the effectiveness of local government’s purchase of older adults care services – a grounded theory study based on typical cases
Authors: Liu Sujun
Published: August 2023

Background

Population aging is a basic national condition in China at present and for a long time to come, forcing the country to accelerate the pace of building its public older adults care system. The government’s purchase of older adults care services has become an effective way to make up for the lack of the family’s older adults care function, to which the Chinese government attaches particular importance. The article selects 11 typical cases from the excellent case base released by the Chinese Ministry of Civil Affairs officials in 2022 to study the influencing factors of the effect of local government purchase of older adults care service supply.

Methods

NVivo data analysis tools have significant advantages in retrieving, analyzing and coding data more efficiently and accurately, which helps to construct theoretical propositions and formulate hypotheses to be tested in qualitative research. The study intends to adopt the grounded theory approach to analyze the text with the help of NVivo12 software, to condense the practice mechanism of local governments’ purchasing of older adults care services and to construct a relational model.

Results

Taking “the supply effect of local government purchasing older adults services” as the main logic line, the article summarizes the four main influencing factors of the supply effect of government purchasing older adults services: the real demand of the society, the government’s power and responsibility system, the government’s governance ability, and the society’s acceptance ability.

Conclusion

The sense of gain, happiness and security of the older adults group is the starting point and landing point of the older adults service policy formulation and implementation. Policy guidance and decision-making have an important impact on the quality of the supply of older adults care services and the development of the older adults care services industry. Clarifying the direction of policy guidance, reflecting the comprehensive efficiency of government governance and utilizing the professional advantages of social forces, is the key to improving the effectiveness of the government’s purchase of older adults care services.