bluuebunny/crossref_metadata_2025 huggingface dataset:
The prevalence of positive urine cultures in 100 dogs with an inactive urine sediment
Authors: Liebelt Rachel , Pigott Armi
Published: December 2019

Objective: The purpose of this study was to determine the prevalence of positive quantitative urine cultures in dogs with an inactive urine sediment.

Background: A urinalysis is a useful screening tool for the evaluation of evidence of bacterial cystitis and a quantitative urine culture is used for definitive diagnosis.

Evidentiary value: A retrospective chart review from June 2012 to December 2017 at three private practice emergency and specialty referral hospitals examined urine samples obtained from 100 client-owned dogs.

Methods: The signalment and clinicopathologic data was recorded for all canine patients that had urine samples obtained by cystocentesis that had an inactive sediment exam on urinalysis and subsequent quantitative urine cultures were performed.

Results: The prevalence of positive quantitative urine cultures in all dogs with an inactive urine sediment at the aforementioned institutions was 6% (6/100). Escherichia coli was the most commonly isolated bacteria.

Conclusion: Given the low prevalence of positive quantitative urine cultures in dogs with an inactive urine sediment and current guideline recommendations for management of subclinical bacteriuria, we do not recommend urine cultures for dogs without lower urinary tract signs. Further prospective study of patient subgroups, as well as controlled studies evaluating urine sample handling techniques using methods available to private practice practitioners are sorely needed.

Application: Emergency and general practicing veterinarians should consider a quantitative urine culture for dogs with lower urinary tract signs, even with an inactive sediment examination, and on a case-by-case basis for dogs with pertinent systemic diseases or known risk factors for bacterial cystitis.
In vitro fracture strength and modes of cast post and cores luted with self-adhesive resin-based cement
Authors: Pomini Marcos C , Machado Marina M , Quadros Giovanny de Paula , Pinheiro Lidia O B , Samra Adriana P B
Published: December 2019

Aim: Cast post and core (CPC) is the main used post type; however, the biomechanical behavior of CPCs adhesively luted to the dentin is still unclear. Therefore, we aimed to evaluate the fracture resistance (FR) and fracture modes of teeth restored with CPCs luted with zinc-phosphate (ZP) or resin-based self-adhesive (SA) cements, as well as the influence of the coronal remnant. Methods: For that, 24 human premolars were divided into four groups according to the cement (ZP or SA) and coronal remnant (with or without 2mm). FR was tested in a universal machine and data analyzed by two-way ANOVA and Tukey HSD (α=.05). Fracture modes were classified according to the degree of dental destruction. Results: The results showed that there was no difference in FR (p=.352); however, teeth without ferrule presented more irreparable fractures, specially in the ZP group. Conclusion: All in all, self-adhesion of CPCs does not enhance fracture resistance, however it reduces the number of irreparable fractures, compared to ZP cement.
Can the chlorhexidine gluconate solution potentiate the staining of polycrystalline ceramic brackets?
Authors: Barros Catharina e Silva Monteiro , Neves Jose Guilherme , Godoi Ana Paula Terossi de , Costa Ana Rosa , Filho Mario Vedovello , Valdrighi Heloisa Cristina
Published: December 2019

Aim: The present study aimed to assess, in vitro, the effect of chlorhexidine on the potentiation of polycrystalline ceramic bracket staining. Methods: Seventy-two polycrystalline ceramic brackets of upper right central incisors were divided into six groups (n=12) according to immersion solution. The groups were G1 - distilled water (control); G2 - chlorhexidine; G3 - coffee; G4 - red wine; G5 - chlorhexidine associated with coffee; and G6 - chlorhexidine associated with red wine. The samples were analyzed by means of a spectrophotometer according to the CIEL*a*b* system, and color change (ΔE*) was calculated. The readings were performed at the following times: T0 - After package removal and T1 - After staining. The data were analyzed by Kruskal Wallis and t tests (p<0.05) at 5% significance level. Results: The total color variation (ΔE*) was greater in the group that received chlorhexidine associated with red wine (p<0.05) and lower in the groups that received distilled water. All other groups showed greater value variations when compared to G1 and G2. Group G6 showed a greater color change due to the potentiation of chlorhexidine with the dye substance. Conclusion: It is concluded that chlorhexidine potentiates the staining caused by red wine in polycrystalline ceramic brackets.
METODOLOGI TAfSIR KONTEMPORER (STUDI KOMPARASI ATAS PEMIKIRAN fAzLUR RAHMAN DAN MUHAMMAD SYAHRUR)
Authors: Zulyadain Zulyadain
Published: December 2019

The main problem of interpretation is actually the giving of meaning and production of meaning, however, there is a difference between Rahman and about the nature of interpretation, for Rahman the essence of interpretation is how an interpreter is able to fnd authentic meaning from a text through socio-historical context the past, then capture the moral ideal aspect to contextualize the meaning in the present era with a new methodology. While syahrur, interpretation does not have to be like that, an interpreter, does not have to determine authentic meaning (original meaning) in the past, but can only immediately search for the meaning of the relevant text in the presentnera, because that meaning can also develop according to contemporary scientifc reasoning. The Qur’an must be seen as if it had just come down yesterday and the Prophet had just greeted us. Thus, Fazlur Rahman and Muhammad Sharur are progressive fgures of Muslims who carry out reforms as well as deconstruction and reconstruction of the study of the Qur’an’s interpretation in the contemporary era. Both are concerned with the Islamic paradigm that touches reality, by offering new interpretations and methodologies to religious teachings, to produce more humanist teachings
Indicadores de adicción a las redes sociales y factores de personalidad eficaz en escolares de secundaria de Lima
Authors: Bueno Cuadra Roberto , Martínez Portillo Armando , Barboza Navarro Evelyn
Published: December 2019

El objetivo fue determinar si existe relación y en qué magnitud entre los factores de personalidad eficaz y los de adicción a las redes sociales en escolares de cuarto y quinto de secundaria. Participaron 304 escolares de dos centros educativos estatales de Lima Metropolitana de 14 a 18 años (M=15,87; DE=0,965). Los datos fueron obtenidos mediante el Cuestionario de Personalidad Eficaz (CPE) de Del Buey et al. y el Cuestionario de Adicción a las Redes Sociales (CARS) de Escurra y Salas. El análisis factorial confirmó la estructura de cuatro factores propuesta por Dapelo et al., para la adaptación chilena del CPE, mientras que en el caso del CARS se optó por una estructura de cinco factores. Se encontró diferencias significativas, aunque con tamaño de efecto nulo, entre hombres y mujeres sólo en cuatro de las cinco dimensiones del CARS. Finalmente se hallaron correlaciones negativas (más de la mitad de ellas a nivel de p<.001) entre los factores de necesidad de conexión, preponderancia y tiempo excesivo, con los cuatro factores de personalidad eficaz.
FDI and Global Economic Integration: A Welfare Analysis
Authors: Wang Yu Ter
Published: December 2019

This paper investigates the welfare impact on all member countries when nonmember countries invest in a member of an economic region, in which capital is allowed to move freely. It is shown that the nonmember investment will affects the welfare of all members despite that some members do not receive such investment directly. In general, the results depend on the relative magnitude of the tariff revenue effect, the tax revenue effect and the capital returns effect. Specific conditions for welfare change in each member country as well as the criterion for a common external tariff which ensures welfare improvement in all the member countries are derived.
To What Extent did Monetary Policy Contribute Towards the Recent Financial Crisis and Subsequent Recession in the US and UK?
Authors: Hu Tao , Davies Ceri
Published: December 2019

This essay researches the question, “To what extent did monetary policy contribute towards the recent financial crisis and subsequent recession in the US and UK?” This article begins by demonstrating monetary policy’s role in guiding the economy’s development under different economic fundamentals. Then the essay puts forward the existence of possibility that monetary policy may cause potential dangers for the economy. In the next chapter, the essay illustrates the guideline for monetary policy namely Taylor rule and economists’ arguments and explanations for the US monetary policy in the past decade. In chapter 3, this article estimates the nominal interest rates for both the US and the UK based on Taylor rule for different periods and illustrates influences of monetary policy actually taken for each country in different periods. In chapter 4, the article tests the relationship between monetary policy’s deviations from Taylor rule and financial imbalances by using the OLS method and explains results. Finally, in chapter 5, the article concludes that in some degree monetary policy’s deviations from Taylor rule prescriptions contribute to a build-up of financial imbalances.
A Systematic Literature Review of Animal Assisted Interventions in Oncology (Part I): Methods and Results
Authors: Holder Timothy , Gruen Margaret , Roberts David , Somers Tamara , Bozkurt Alper
Published: December 2019

Animal-assisted interventions (AAI) use human-animal interactions to positive effect in various contexts including cancer care. This systematic literature review is the first part of a two-part paper series focusing on the research methods and quantitative results of AAI studies in oncology. We find methodological consistency in the use of canines as therapy animals, in the types of high-risk patients excluded from studies, and in the infection precautions taken with therapy animals throughout cancer wards. The investigated patient endpoints are not significantly affected by AAI, with the exceptions of improvements in oxygen consumption, quality of life, depression, mood, and satisfaction with therapy. The AAI field in oncology has progressed significantly since its inception and has great potential to positively impact future patient outcomes. To advance the field, AAI research in oncology should consistently improve the methodological design of studies, report data more completely, and focus on the therapy animal’s well-being.
Use of Land Use Change Analysis between 2012–2018 to Assessment of Sustainable Development in Europe
Authors: Gibas Piotr , Majorek Agnieszka
Published: December 2019

The article presents the author's method of land use change assessment in the context of sustainable development and the results of its application based on the transformations that occurred in individual areas of Europe in the years 2012–2018. This method is based on data from the CORINE Land Cover program and local government units presenting the degree of urbanization (DEGURBA). The authors evaluate the transformations taking place in space, reducing them to economic, social and environmental dimensions. They then analyse the results in terms of space (covering the entire Europe) and in terms of division into: large cities, small towns as well as suburbs and rural areas. It has been shown that: development of the economic dimension most often takes place at the expense of natural resources; the higher the population density and more important function in the functional system of a given country, the greater the sustainable development differentiation level in the analysed dimensions, of which the social dimension is characterized by the lowest differentiation and the economic dimension is the highest; development of rural areas is less sustainable than in case of large urban centres. The result interpretation also leads to the conclusion that the areas of Europe are very diverse in terms of sustainable development. However, the method itself, despite the imperfections observed by the authors, may be used in further or similar studies.
Financial Market Prediction Using Recurrence Plot and Convolutional Neural Network
Authors: Hailesilassie Tameru
Published: December 2019

An application of deep convolutional neural network and recurrence plot for financial market movement prediction is presented. Though it is challenging and subjective to interpret its information, the pattern formed by a recurrence plot provide a useful insight into the dy- namical system. We used a recurrence plot of seven financial time series to train a deep neural network for financial market movement predic- tion. Our approach is tested on our dataset and achieved an average of 53.25% classification accuracy. The result suggests that a well trained deep convolutional neural network can learn a recurrence plot and pre- dict a financial market direction.
PAPR Impact over the PER of Vehicle-to-Vehicle Communications with Fading Channels
Authors: Carreño Italo Alexander , Eras Frank Andrés , Borja Thomás , Reinoso Diego Javier , Urquiza-Aguiar Luis , Paredes Paredes Martha Cecilia
Published: December 2019

Peak-to-Average Power Ratio (PAPR) is one of the main problems in wireless communications using Orthogonal Frequency Division Multiplexing (OFDM). Its behavior is random and can produce problems for the hardware implementation, directly influencing the Packet Error Rate (PER). In this article, the PER is obtained for channels with Rayleigh and Rician fading. In the simulation, a High Power Amplifier (HPA) is added to the transmitter and for PAPR reduction Simple Amplitude Predistortion-Orthogonal Pilot Sequences (OPS-SAP) technique is used.
Shape Adaptation of the Inspection Guide Frame in Tunnels to Avoid Obstacles Detected by a Laser Range Finder
Authors: Inoue Fumihiro , Kwon Soonsu , Nakamura Satoru , Yanagihara Yoshitaka ,   Shonan Institute of Technology 1-1-25 Tsujidonishikaigan, Fujisawa-shi, Kanagawa 251-8511, Japan,   Institute of Technology, Tokyu Construction Co., Ltd. 3062-1 Tana, Chuo-ku, Sagamihara, Kanagawa 252-0244, Japan,   ICT Strategy Department, Corporate Strategy Division, Tokyu Construction Co., Ltd. 1-16-14 Shibuya, Shibuya-ku, Tokyo 150-8340, Japan
Published: December 2019

To advance the automated inspection and maintenance of the inner wall of tunnels, an advanced inspection system aimed at regulating traffic was developed. In this inspection system, a guide frame was installed along the tunnel ceiling wall that is above the protection frame built over the road and resembles a gantry crane. The inspection device was fitted with an inspection guide frame (IGF), which stabilized its movement and improved its accuracy. However, as this protection frame moves along the tunnel, the guide frame should have the capacity to avoid convex obstacles such as the duct fan, the lamp and road traffic signs within the tunnel. Therefore, the entire inspection guide frame is made of variable geometry truss (VGT), which makes it possible to suitably alter the shape of the guide frame whenever necessary and pass it through the tunnel. To enable the guide frame adapt to any shape, the inverse analysis method and mathematical interpolation method were applied. The orientation of each frame was reversely analyzed according to the shape of the obstacle measured using the laser range finder (LRF), and the frame’s actuator was controlled simultaneously. We investigated the construction of a system that can perform a series of tasks such as searching for obstacles and positioning, frame shape simulation, frame shape change, inspection of the device and movement. By applying spline interpolation, we managed to practically determine the shape of the guide frame that would avoid obstacles.
Development of Concrete Inspection Robot with Dual Stage Suckers
Authors: Matsumoto Yuta , Kurashige Isao , Yoneda Kan ,   Chiba Institute of Technology 2-17-1 Tsudanuma, Narashino-shi, Chiba 275-0016, Japan,   Central Research Institute of Electric Power Industry 1646 Abiko, Chiba 270-1194, Japan
Published: December 2019

To automate nondestructive inspections for concrete walls by measuring their air permeability, we developed a wall climbing robot with suckers. It is configured to move by alternately moving the central body and the four leg tip suckers forward. The central sucker is a triple ring type, making it useful for climbing and measuring as well as acquiring the air permeability data in the depth direction. The leg tip suckers use a sponge material to ensure good sealing with the concrete wall and are double suckers when incorporated with bellows to generate power that sticks them fast, by pressing the bellows at the beginning of the fast-sticking process. The dual stage fast-sticking process first sucks by using the bellows only and then the whole sucker follows after the sponge parts are almost fast stuck. To automate the dual stage fast-sticking process, we developed two automatic switching systems: one switches relative to the distance between the sucker and the wall surface and the other, relative to the pressure in the bellows. We experimentally demonstrated that with both switching systems, when the sucker approaches a concrete wall with a weak force, the first stage fast-sticking process takes 1 s or lesser and the complete fast-sticking process, approximately 5 s. We also proved that the developed wall climbing robot incorporating the above-mentioned fast-sticking mechanism can climb a concrete wall at approximately 440 mm/min to acquire the concrete’s nondestructive air permeability test data.
Development of a Bridge Inspection Support Robot System Using Two-Wheeled Multicopters
Authors: Nakao Manabu ,   Fujitsu Laboratories Limited 4-1-1 Kamikodanaka, Nakahara-ku, Kawasaki-shi, Kanagawa 211-8588, Japan, Hasegawa Eiji , Kudo Taku , Sawasaki Naoyuki
Published: December 2019

We developed a bridge inspection support robot system that uses a two-wheeled multicopter and 3D modeling technology. Our system is divided into three main parts: 1) a two-wheeled multicopter to capture close-up images of the inspection target, 2) damage extraction using 3D modeling technology, and 3) a 3D model-based bridge maintenance system that stores inspection information linked with the Industry Foundation Classes (IFC) 3D product model. An inspector can use this system to visually inspect the overall structure and accurately detect hairline cracks.
Analysis of Fast Bipedal Walking Using Mechanism of Actively Controlled Wobbling Mass
Authors: Hanazawa Yuta , Hayashi Terumitsu , Yamakita Masaki , Asano Fumihiko ,   Department of Mechanical and Control Engineering, Kyushu Institute of Technology 1-1 Sensui, Tobata, Kitakyushu, Fukuoka 804-8550, Japan,   Yaskawa Electric Corporation 2-1 Kurosaki-shiroishi, Yahata-nishi, Kitakyushu, Fukuoka 806-0004, Japan,   Department of Mechanical and Control Engineering, Tokyo Institute of Technology 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8552, Japan,   School of Information Science, Japan Advanced Institute of Science and Technology 1-1 Asahidai, Nomi, Ishikawa 923-1292, Japan
Published: December 2019

In this study, a novel approach was developed to achieve fast bipedal walking by using an actively controlled wobbling mass. Bipedal robots capable of achieving energy efficient limit cycle walking have been developed, and researchers have studied methods to increase their walking speed. When humans walk, their arm swinging is coordinated with the walking phases, generating a regular symmetrical motion about the torso. The bipedal robots with a wobbling mass in the torso mimicked the arm swinging by the proposed control method. We demonstrated that the proposed method is capable of increasing the bipedal walking speed.
Jigsaw in teaching circulatory system: a learning activity on elementary science classroom
Authors: Leasa Marleny , Sanabuky Yakub Lalyolik , Batlolona John Rafafy , Enriquez Javier Julia
Published: December 2019

Jigsaw type cooperative learning is explored again to train students from an early age to become a small expert to reveal the effects it has on the cognitive achievement of elementary students. The study was conducted at one of the public schools in Ambon City, preceded by a placement test on the classes used. The cognitive learning achievement test instrument was developed with a cognitive load reaching C4 and has met the instrument quality prerequisite tests. The results of the study prove that there are differences in student learning outcomes in learning with Jigsaw and Example Non-Example (ENE) types. The corrected mean score showed that the treatment group was 25,856 points higher than the control group. This means that Jigsaw is superior in improving student cognitive achievement compared to ENE. Thus, Jigsaw can be used in other learning in elementary school because it has the potential to enhance student learning outcomes. Further studies are needed to uncover the potential of Jigsaw to empower various types of learning outcomes and other thinking skills.
Experiential learning model with mind mapping on fungi: how to improve science process skills?
Authors: Indriani Desi , Mercuriani Ixora Sartika
Published: December 2019

This research aimed to find out the effectiveness of experiential learning (EL) model with mind mapping to improve the science process skills (SPS) on fungi materials. It was quasi-experiment research by using pre-test post-test control group design. The population of the study was all of the tenth-grade students of Kalasan State 1 Senior High School amount of 127 students in the odd semester in 2018/2019 of the school year. Sample techniques were cluster random sampling. The sample consisted of 26 students (10 students male and 16 students female) as the experiment class by implementing EL model with mind mapping and 26 students (9 students male and 17 students female) as control class by using 5M (observing, asking, collecting, associating, communicating) learning model. The used instrument was ten essay questions. The data of the research were analyzed by using t-test (independent sample t-test). Based on the result of the normalized gain score, it showed that there was an improve of SPS about 0,85 in the experiment class higher than that in the control class about 0,70. Besides, it also showed a significant value (2-tailed) that was 0,000 (<0,05). It meant that there was a difference in science process skills between the experiment class and control class, so the learning process through EL learning model with mind mapping proved useful to improve the students’ science process skills.
TRACE FOSSILS OF PROBLEMATIC ORIGIN: ASSESSING SILICIFIED TRACE FOSSILS FROM THE PERMIAN OF UTAH, U.S.A.
Authors: WISTORT ZACKERY P. , RITTERBUSH KATHLEEN A. , EKDALE A. A.
Published: December 2019

Silicification is a diagenetic process that can affect the fidelity of trace fossil preservation. The combination of compaction and oversilicification associated with chert precipitation can alter the original fabric created by the trace producers. Sedimentary structures and trace fossils in mixed chert-carbonate systems are especially prone to these processes, leading to the preservation of a limited or biased ichno-assemblage and the omission of important paleoecologic detail. We summarize useful criteria for identifying chert-associated trace fossils and present a formal naming scheme. Using this nomenclature, we identified silicified trace fossils in the chert-rich Permian strata from northwestern Utah. An assemblage of burrows is present in outcrops of the Trapper Creek Formation, consisting of nodule-like growths of microcrystalline quartz in close association with bioturbated horizons. Thin section micro-textures of burrow fill lend additional support to the bioturbated origin of chert nodules. Silicified Thalassinoides fossils are present, as are chert nodules with a Rhizocorallium-like morphology.
Revisión de la literatura en el diagnóstico imagenológico del quiste dentígero
Authors: Castro Pesce Rubén Alfredo
Published: December 2019

El quiste dentígero, incluido dentro de la clasificación de los quistes odontogénicos por la OMS en el 2017, constituye una patología relevante en el áreabuco maxilofacial. Si bien su crecimiento es lento y asintomático, cuando alcanza grandes dimensiones, tiene capacidad para provocar destrucción ósea enlos maxilares, lo que ocasiona alteraciones estéticas y funcionales. Además, presenta una alta prevalencia, con el quiste odontogénico como el más común,después del quiste radicular inflamatorio. La radiología representa una herramienta fundamental en su diagnóstico y muchas veces su detección constituyeun hallazgo radiográfico. Normalmente, se emplean técnicas en 2D como la radiografía periapical, panorámica y oclusal, las cuales cumplen un rol muyimportante en su detección y diagnóstico. No obstante, debe considerarse que la similitud del quiste dentígero con otros procesos patológicos, tanto a nivel clínico como radiográfico, muchas veces lleva a un diagnóstico y tratamiento inadecuado. Con este trabajo se pretende evidenciar si el advenimiento de nuevas tecnologías como la resonancia magnética y la tomografía computarizada de haz cónico permiten mejorar la posibilidad del diagnósticodel quiste dentígero y distinguirlo de otras lesiones o patologías con las cuales se realiza el diagnóstico diferencial.
Sex-specific impact of patterns of imageable tumor growth on survival of primary glioblastoma patients
Authors: Whitmire Paula , Rickertsen Cassandra R , Hawkins-Daarud Andrea , Carrasco Eduardo , Lorence Julia , De Leon Gustavo , Curtin Lee , Bayless Spencer , Clark-Swanson Kamala , Peeri Noah , Corpuz Christina , Angeles Christine Paula Lewis-de los , Bendok Bernard , Gonzalez-Cuyar Luis , Vora Sujay , Mrugala Maciej M , Hu Leland , Wang Lei , Porter Alyx , Kumthekar Priya , Johnston Sandra , Egan Kathleen , Gatenby Robert , Canoll Peter , Rubin Joshua , Swanson Kristin
Published: December 2019

Background : Sex is recognized as a significant determinant of outcome among glioblastoma patients, but the relative prognostic importance of glioblastoma features has not been thoroughly explored for sex differences. Methods : Combining multi-modal MR images, biomathematical models, and patient clinical information, this investigation assesses which pretreatment variables have a sex-specific impact on the survival of glioblastoma patients (299 males and 195 females). Results : Among males, tumor (T1Gd) radius was a predictor of overall survival (HR=1.027, p=0.044). Among females, higher tumor cell net invasion rate was a significant detriment to overall survival (HR=1.011, p<0.001). Female extreme survivors had significantly smaller tumors (T1Gd) (p=0.010 t-test), but tumor size was not correlated with female overall survival (p=0.955 CPH). Both male and female extreme survivors had significantly lower tumor cell net proliferation rates than other patients (M p=0.004, F p=0.001, t-test). Conclusion : Despite similar distributions of the MR imaging parameters between males and females, there was a sex-specific difference in how these parameters related to outcomes.
Group B Streptococcus detection in pregnant women: comparison of real-time PCR assay, culture, and the Xpert GBS rapid test
Authors: Vieira Laura , Perez Amanda Vilaverde , Machado Monique M , Kayser Michele L , Vettori Daniela V , Alegretti Ana Paula , Ferreira Charles Francisco , Vettorazzi Janete , Valério Edimárlei G
Published: December 2019

Background: Group B Streptococcus (GBS) is one of the most important causative agents of neonatal sepsis. As administration of prophylactic antibiotics during labor can prevent GBS infection, routine screening for this bacterium in prenatal care before the onset of labor is recommended. However, many women present in labor without having undergone such testing during antenatal care, and the turnaround time of detection methods is insufficient for results to be obtained before delivery. Methods: Vaginal and anorectal specimens were collected from 270 pregnant women. Each sample was tested by Xpert GBS, qPCR, and culture for GBS detection. Results: The overall prevalence of maternal GBS colonization was 30.7% according to Xpert GBS, 51.1% according to qPCR, and 14.3% according to cultures. Considering the qPCR method as the reference, the Xpert GBS had a sensitivity of 53% and specificity of 93%. Positive Xpert GBS results were correlated to marital status (married or cohabitating) and with prematurity as a cause of neonatal hospitalization. Positive cultures were related with ischemic–hypoxic encephalopathy requiring therapeutic hypothermia. Conclusions: Combined enrichment/qPCR and the Xpert GBS rapid test found a high prevalence of GBS colonization. The Xpert GBS technique gives faster results and could be useful for evaluating mothers who present without antenatal GBS screening results and are at risk of preterm labor, thus allowing institution of prophylactic antibiotic therapy. Keywords: Group B Streptococcus ; Streptococcus agalactiae ; Xpert GBS; real-time polymerase chain reaction; antenatal care
Neonatal Survival and Determinants of Mortality in Aroresa District, Southern Ethiopia: a Prospective cohort study
Authors: Limaso Alaka Adiso , Dangisso Mesay Hailu , Hibstu Desalegn Tsegaw
Published: December 2019

Background: The first day, week and month of life are the most critical period for the survival of children. In Ethiopia, despite a significant reduction in under-five mortality during the last fifteen years, neonatal mortality remains a public health problem accounting for 47% of under-five mortality. Understanding neonatal survival and risk factors for neonatal mortality could help devising tailored interventions. The aim of this study was to determine the neonatal survival and risk factors for neonatal mortality in Aroresa district, Southern Ethiopia. Methods: A community based prospective follow up study was conducted among a cohort of term pregnant mothers and neonates delivered from January 1/2018 to March 30/2018. A total of 586 term pregnant mothers were selected with a multistage sampling technique and 584 neonates were followed-up for a total of 28 days, with 12 twin pairs. Data were coded, entered cleaned and analyzed using SPSS version 22. Kaplan–Meier survival curve was used to show pattern of neonatal death in 28 days. Independent and adjusted relationships of different predictors with neonates’ survival were assessed with Cox regression model. The risk of mortality was explored and presented with hazard ratio and 95% confidence interval and P-value less than 0.05 were considered as significant. Result: The overall neonatal mortality was 41 per 1000 live births. Hazards of neonatal mortality was high for neonates with complications (AHR=3.643; 95% CI, 1.36-9.77), male neonates (AHR=2.71; 95% CI, 1.03-7.09), mother’s perception of being small baby’s size (AHR=3.46; 95% CI, 1.119-10.704), neonates who had initiated exclusive breast feeding (EBF) after one hour (AHR=3.572; 95% CI, 1.255-10.165) and mothers who had no postnatal care (AHR=3.07; 95% CI, 1.16-8.12). Conclusion: Neonatal mortality in the study area was 4.1% which was high and immediate action should be taken towards achieving the Sustainable Development Goals. To improve neonatal survival, high impact interventions such as promotion of maternal service utilization, essential newborn care and early initiation of exclusive breast feeding were recommended.
Screening and Socioeconomic Associations of Dyslipidemia in Young Adults
Authors: Hudson Stephen E , Feigenbaum Matthew S. , Patil Nirav , Ding Elan , Ewing Alex , Trilk Jennifer L.
Published: December 2019

Background and Objective
The Southern region of the United States is home to substantial populations with obesity, dyslipidemia, and hypertriglyceridemia, while also housing a large percentage of America’s minority, rural, and low socioeconomic status (SES) peoples. Adult-onset cardiovascular disease (CVD) research may be informed by investigating associations(s) between late adolescent demographic variables and lipid values. Our objective was to investigate lipid parameter associations with college-age socioeconomic status, which may improve age-specific screening algorithms for management or prevention of adult-onset CVD.

Methods
Using an Analysis of Variance test and a general linear model, associations between gender, race/ethnicity, SES, and athletic participation on lipid parameters (VLDL-C, LDL-C, TG, TC, and HDL-C) were analyzed in 4423 private liberal arts college students enrolled in freshman-level wellness courses at Furman University in Greenville, SC. Comparative data were collected from an age-matched sample (National Health and Nutrition Examination Survey: NHANES 2003-2016). Our main outcomes were statistically significant relationships between any lipid values (TC, HDL-C, LDL-C, TG) and any demographic variables (gender, SES, ethnicity, athlete status).

Results
Males demonstrated lower TC and LDL-C, and higher HDL-C values. HDL-C was highest in athletes. African-American students demonstrated healthier VLDL-C, TG, and HDL-C values. With similar distributions, the age-matched NHANES comparison group showed unhealthier values in nearly all categories.

Conclusions
College students may have better lipid health than the general population. African-Americans may have seemingly healthier lipid values than age-matched individuals independent of athletic or college enrollment which has already been demonstrated in other studies. Future research should include SES relationships in lipid screening paradigms along with other appropriate risk factors for cardiovascular disease. Based on our comparative data, pediatric health providers and researchers may consider education as a potential protective factor against poor lipid health when considering lipid screening protocols for students.

Keywords: lipid, high-density lipoprotein, low-density lipoprotein, socioeconomic status, cardiovascular disease.
Insight into Blood Pressure Targets for Universal Coverage of Hypertension Services in Iran: The 2017 ACC/AHA versus JNC 8 Hypertension Guidelines
Authors: Mahdavi Mahdi , Parsaeian Mahboubeh , Mohajer Bahram , Modirian Mitra , Ahmadi Naser , Yoosefi Moein , Mehdipour Parinaz , Djalalinia Shirin , Rezaei Nazila , Haghshenas Rosa , Pazhuheian Forough , Madadi Zahra , Sabooni Mahdi , Razi Farideh , Samiee Siamak Mirab , Farzadfar Farshad
Published: December 2019

Background: We assessed and compared the prevalence, awareness, treatment, and control of hypertension in Iran under two hypertension guidelines; the 2017 ACC/AHA with an aggressive blood pressure target 130/80 mm Hg and commonly used guideline JNC8 with 140/90 mm Hg. We shed light on the implications of 2017 ACC/AHA for population subgroups and high-risk individuals eligible for non-pharmacologic and pharmacologic therapies.
Methods: Data were obtained from the Iran national STEPS 2016 study. Participants included 27 738 adults ≥25 years as a representative sample of Iranians. The logistic regression models with a survey design were used to examine the determinants of prevalence, awareness, treatment, and control of hypertension.
Results: The prevalence of hypertension based on JNC8 was 29.9% (95% CI: 29.2-30.6), which soared to 53.7% (52.9-54.4) by 2017 ACC/AHA. Awareness, treatment, and control were 59.2% (58.0-60.3), 80.2% (78.9-81.4), and 39.1% (37.4-40.7) based on JNC8, which dropped to 37.1% (36.2-38.0), 71.3% (69.9-72.7), and 19.6% (18.3-21.0) respectively by 2017 ACC/AHA. By new guideline, adults 25-34 years had the largest increase in prevalence (from 7.3% to 30.7%). They also had the lowest awareness and treatment rate but the highest control rate (36.5%) among age groups. Compared with JNC8, under 2017 ACC/AHA, 24%, 15%, 17%, and 11% more individuals with dyslipidaemia, high triglyceride, diabetes, and cardiovascular disease (CVD) events respectively fell into the hypertensive category. Yet, based on 2017 ACC/AHA, 68.2% of individuals falling into a hypertensive group were supposed to receive medications (versus 95.7% in JNC8). LDL cholesterol, physical activity, and one unit of Body Mass Index were found to change blood pressure by -3.56 (-4.38, -2.74), -2.04 (-2.58, -1.50), and 0.48 (0.42, 0.53) mm Hg respectively.
Conclusions: Switching from JNC8 to 2017 ACC/AHA highlighted sharp increases in prevalence and drastic declines in awareness, treatment, and control in Iran. By the 2017 ACC/AHA, more young adults and those with chronic comorbidities fell into the hypertensive category, thus might benefit from earlier interventions such as lifestyle modifications. The low control rate among treated individuals calls for a critical review of hypertension services in Iran.
Population Genetic Structure and Habitat Connectivity for Jaguar (Panthera onca) Conservation in Central Belize.
Authors: Menchaca Angelica , Rossi Natalia , Froidevaux Jeremy , Dias-freedman Isabela , Caragiulo Anthony , Wultsch Claudia , Harmsen Bart , Foster Rebecca , Torre Antonio de la , Medellin Rodrigo , Rabinowitz Salisa , Amato George
Published: December 2019

Connectivity among jaguar (Panthera onca) populations will ensure natural gene flow and the long-term survival of the species throughout its range. Jaguar conservation efforts have focused primarily on connecting suitable habitat in a broad-scale. Accelerated habitat reduction, human-wildlife conflict, limited funding, and the complexity of jaguar behaviour have proven challenging to maintain connectivity between populations effectively. Here, we used non-invasive genetic sampling and individual-based conservation genetic analyses to assess genetic diversity and levels of genetic connectivity between individuals in the Cockscomb Basin Wildlife Sanctuary and the Maya Forest Corridor. We used expert knowledge and scientific literature to develop models of landscape permeability based on circuit theory with fine-scale landscape features as ecosystem types, distance to human settlements and roads to predict the most probable jaguar movement across central Belize.

Results
We used 12 highly polymorphic microsatellite loci to identify 50 individual jaguars. We detected high levels of genetic diversity across loci (HE= 0.61, HO= 0.55, and NA=9.33). Using Bayesian clustering and multivariate models to assess gene flow and genetic structure, we identified one single group of jaguars (K = 1). We identified critical areas for jaguar movement that fall outside the boundaries of current protected areas in central Belize. We detected two main areas of high landscape permeability in a stretch of approximately 18 km between Sittee River Forest Reserve and Manatee Forest Reserve that may increase functional connectivity and facilitate jaguar dispersal from and to Cockscomb Basin Wildlife Sanctuary. Our analysis provides important insights on fine-scale genetic and landscape connectivity of jaguars in central Belize, an area of conservation concern.

Conclusions
The results of our study demonstrate high levels of relatively recent gene flow for jaguars between two study sites in central Belize. Our landscape analysis detected corridors of expected jaguar movement between the Cockscomb Basin Wildlife Sanctuary and the Maya Forest Corridor. We highlight the importance of maintaining already established corridors and consolidating new areas that further promote jaguar movement across suitable habitat beyond the boundaries of currently protected areas. Continued conservation efforts within identified corridors will further maintain and increase genetic connectivity in central Belize.
Comparison of Cytokine Levels in the Aqueous Humor of Polypoidal Choroidal Vasculopathy and Neovascular Age-Related Macular Degeneration Patients
Authors: Zhou Huiying , Zhao Xinyu , Yuan Mingzhen , Chen Youxin
Published: December 2019

Background The concentrations of cytokines in the aqueous humor from neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV) may vary. The study was conducted to compare various cytokine levels in the aqueous humor of eyes with PCV, nAMD and control. Methods The present case control study included 49 treatment-naïve eyes from 49 patients (PCV 24, nAMD 11, and cataract 14 eyes). Totally 34 angiogenic and inflammatory cytokines in the aqueous humor were measured by Luminex bead-based multiplex array. Results After adjusting for gender and age by multivariate logistic analysis, concentrations of IL-31, LIF, SDF1-α, VEGF-A, VEGF-D were significantly higher in eyes with nAMD or PCV compared with control eyes (all P<0.05, times in nAMD: 59.5, 6.0, 7.0, 4.5, 5.6, respectively, times in PCV: 51.9, 5.21, 6.6, 4.0, 5.1, respectively ), and concentrations of HGF, IP-10, MCP-1, IL-13 were significantly lower in eyes with nAMD or PCV than in control eyes (all P<0.05, times in nAMD: 2.6, 2.0, 4.5, 4.7, respectively, times in PCV: 1.9, 3.0, 3.0, 2.8, respectively), but none of the 34 cytokines, including VEGF and IL-8, showed significantly different between eyes with nAMD and PCV. Conclusions Various cytokines involved in inflammation and angiogenesis including elevated IL-31, LIF, SDF1-α, VEGF-A, VEGF-D might be involved in the pathogenesis of nAMD or PCV. None of the 34 cytokines may help to differentiate nAMD and PCV.
Reporting guideline for priority setting of health research (REPRISE)
Authors: Tong Allison , Synnot Anneliese , Crowe Sally , Hill Sophie , Matus Andrea , Scholes-Robertson Nicole , Oliver Sandy , Cowan Katherine , Nasser Mona , Bhaumik Soumyadeep , Gutman Talia , Baumgart Amanda , Craig Jonathan C
Published: December 2019

Background Research priority setting with stakeholders can help direct the limited resources for health research toward priority areas of need. Ensuring transparency of the priority setting process can strengthen legitimacy and credibility for influencing the research agenda. This study aims to develop a reporting guideline for priority setting of health research. Methods We searched electronic databases and relevant websites for sources (frameworks, guidelines, or models for conducting, appraising, reporting or evaluating health research priority setting, and reviews (including systematic reviews)), and primary studies of research priority setting to July 2019. We inductively developed a list of reporting items and piloted the preliminary guideline with a diverse range of 30 priority setting studies from the records retrieved. Results From 21556 records, we included 26 sources for the candidate REPRISE framework and 455 primary research studies. The REporting guideline for PRIority SEtting of health research(REPRISE) has 31 reporting items that cover 10 domains: context and scope, governance and team, framework for priority setting, stakeholders/participants, identification and collection of priorities, prioritization of research topics, output, evaluation and feedback, translation and implementation, and funding and conflict of interest. Each reporting item includes a descriptor and examples. Conclusions The REPRISE guideline can facilitate comprehensive reporting of studies of research priority setting. Improved transparency in research priority setting may strengthen the acceptability and implementation of the research priorities identified, so that efforts and funding are invested in generating evidence that is of importance to all stakeholders.
A maternal GOT1 novel variant associated with early-onset severe preeclampsia identified by whole-exome sequencing
Authors: Zhang Lin , Cao Zheng , Feng Fan , Xu Ya-Nan , LI LIN , Gao Hong
Published: December 2019

Purpose This study wants to know the genetic cause of preeclampsia (PE) which is a leading cause of maternal and perinatal death, but the underlying molecular mechanisms that cause PE remain poorly understood. Many single nucleotide polymorphisms have been identified by genome-wide association studies and were found to be associated with PE; however, few studies have used whole-exome sequencing (WES) to identify PE mutations. Methods Five patients with severe early-onset preeclampsia (EOPE) were recruited, and WES was performed on each patient. Sanger sequencing was used to confirm the potential causative genetic mutation. Results After a stringent bioinformatics analysis, a rare mutation in the GOT1 gene, c.44C>G:p.P15R, was found in one patient. Bioinformatics analysis showed that the mutation site is highly conserved across several species and was predicted to be a pathogenic mutation according to several online mutational function prediction software packages. Further structural biology homology modeling suggested that P15R would change the electric environment of enzymatic center, and might affect the binding affinity of substrate or product. Conclusion We demonstrated for the first time that the mutation in GOT1 may be associated with EOPE, the results of this study provide researchers and clinicians with a better understanding of the molecular mechanisms that underlie maternal severe EOPE.
The effects of protective lung ventilation on regional cerebral oxygen saturation in intracranial tumor operation during dura opening：study protocol for a randomized controlled trial.
Authors: Li Jinlu , Wu Xuemei , Liu Hairui , Huang Ying , Liu Yueqin , Xie Hong , Dong Jun
Published: December 2019

Objective: To investigate the effects of protective lung ventilation on regional cerebral oxygen saturation during dura opening, that is from Ta (after dura opening) to Tb (before dura closing), in patients undergoing intracranial tumor surgery. Methods: This is a randomized, controlled trial which will be carried out at the second affiliated hospital of Soochow University. Fifty-four patients undergoing intracranial tumor surgery will be randomly allocated to the control group (C group) or the protective lung ventilation group (P group). In the C group, tidal volume (VT) will be set at 8 ml/kg of predicted body weight, but positive end-expiratory pressure (PEEP) and recruitment maneuvers will not be used. In the P group, VT will be set at 6 ml/kg of predicted body weight combined with individualized PEEP during dura opening, while in other periods of general anesthesia, VT will be set at 8 ml/kg of predicted body weight. Regional cerebral oxygen saturation (rSO2), partial pressure of oxygen (PaO2) and carbon dioxide (PaCO2), oxygenation index (OI), lactic acid level (Lac) in arterial blood, and mean arterial pressure (MAP) will be compared before anesthesia (T0), before dura opening (T1), after dura closing (T2) and 24 h after surgery (T3). Lung ultrasound scores (LUS) will be performed at T0 and T3. The degree of brain relaxation at T1 and T2 will be evaluated by the surgeon using the brain relaxation scale. Amount of vasoactive drugs used and blood loss will be recorded during surgery. The duration of operation and reoperation rate will be recorded.The primary outcome of this study is the changes in rSO2 within 24 hours postoperatively. Discussion: This study aims to determine whether protective lung ventilation during dura opening can improve regional cerebral oxygen saturation and the state of pulmonary ventilation in patients undergoing intracranial tumor surgery, and to investigate whether this strategy does not affect the degree of brain tissue swelling and the reoperation rate after operation. If our results are positive, this study will show that protective lung ventilation during dura opening can be used effectively and safely in neurosurgical patients undergoing craniotomy for tumor resection. Trial registration: chictr.org.cn, ID: ChiCTR1900025632. Registered on 3 September 2019. Study protocol version3.0. Keywords: Randomized controlled trial, Regional cerebral oxygen saturation, Lung ultrasound, Brain relaxation, Craniotomy