bluuebunny/crossref_metadata_2025 huggingface dataset:
Исследование параметров внутренней картины болезни пациентов ревматологического профиля
Authors: Ялтонский Владимир М. , Абросимов Илья Н. , Андрушкевич Тамара Д. , Шашурина Елизавета М.
Published: May 2020

Introduction. A patient’s subjective pattern of disease (SPD) is considered both as a result of his/her adjustment to disease and as an instrument of personal self-regulation in disease. Modern clinical psychology actively investigates this psychological construct, which expands available knowledge obtained in the process of determining psychological factors of the treatment process. The present study appears to be the first that examines rheumatoid patients using a SPD multilevel model, which focuses on illness perceptions and coping with it. Methods. The study sample consisted of 80 patients with rheumatic diseases aged 18–52 years, 50 % of whom were patients with rheumatoid arthritis (RA) and 50 % of whom were patients with systemic lupus erythematosus (SLE). The study used the following techniques for assessing the structure and content of various levels of the subjective pattern of disease: (a) the Symptoms Check-List-90-Revised (SCL-90-R), (b) the Brief Inventory of Illness Perceptions, and (c) the technique for psychological assessment of coping with stressful and problematic events. Results. In the comparison groups, significant differences were observed on the scales of illness perceptions (‘illness understanding’, ‘course of illness’, ‘control of illness’, ‘control of treatment’), the scales of coping behavior (‘search for social support’, ‘acceptance of responsibility’), and the scales of ‘somatization’, ‘depression’, and ‘anxiety’. The correlations indicate associations among the parameters of various levels of the subjective pattern of disease in patients in both groups. Discussion. The parameters of the subjective pattern of disease in patients with systemic lupus erythematosus indicate their desire to recognize and overcome uncertainty and unpredictability of their disease. However, this does not reduce their emotional involvement in the problem. The subjective pattern of disease in patients with rheumatoid arthritis is characterized by a worse understanding and control of disease, as well as by emotion-focused coping strategies aimed at distancing from anxiety-related experiences associated with their disease.
Проблема оценки эквивалентности компьютерных и традиционных версий психодиагностических методик
Authors: Гнедых Дарья С.
Published: May 2020

Introduction. This paper (a) discusses the theoretical and methodological evidence for the equivalence of computerized and conventional versions of psychological tests, (b) analyzes the studies investigating psychometric parameters of computerized versions of conventional tests, and (c) examines contradictions in approaches to assessing the equivalence of the two test forms. This paper represents a first effort in structuring the main problems in establishing the equivalence of paper-and-pencil and computer-based testing, as well as in finding ways and means to overcome them. Much attention is devoted to minimal and sufficient mathematical and statistical tools for assessing the equivalence of the two test forms. Theoretical Basis. The main problems associated with assessing the equivalence of computerized and conventional tests include the following: (a) the level of cultural and informational competence of respondents, (b) anxiety, (c) social environment, (d) motivation for testing, (e) difficulties in creating the same conditions for paper-and-pencil and computer-based testing (L. N. Babanin, Y. P. Chua, M. Russell, P. Květon et al.). Researchers most often choose the following procedures for assessing the equivalence of the two versions of psychological tests: (a) comparison of the main statistical parameters (mean values, variances, etc.) and (b) assessment of construct validity and reliability of the computer-based versions of psychological tests. Results and Discussion. The analysis of research methodology for assessing the equivalence of computerized and conventional versions of psychological tests focuses on a variety of approaches to (a) the use of mathematical and statistical methods for assessing psychometric parameters of computer-based versions of conventional tests, (b) the choice of research design, (c) considering specific characteristics of the situation of computer-based testing. It is necessary to formulate specific and structured requirements for the procedure for assessing the equivalence of computerized and conventional versions of psychological tests. The author suggests recommendations for the main sections of such requirements related to (a) the procedure for conducting empirical research, (b) mathematical and statistical methods, and (c) control of the factors specific to computer-based testing that may have impact on the results of equivalence assessment.
Темпоральные особенности студентов как когнитивные диагностические характеристики: контекст адаптивного образования
Authors: Бредун Екатерина В. , Баланёв Дмитрий Ю. , Ваулина Татьяна А. , Краснорядцева Ольга М. , Щеглова Элеонора А.
Published: May 2020

Introduction. The article presents the results of an experimental study of the individual temporal characteristics of cognitive space management in students while solving problems. Methods. The methodological tools are briefly described, including traditional test questionnaires for identifying temporal features of subjective perception of time (‘Semantic Time Differential’, ‘Time Perspective’), as well as modified and original research methods for identifying temporal characteristics of the cognitive activity of subjects in solving spatial problems in a laboratory experiment (‘Mental rotation’, ‘Accuracy’). Results. In a series of laboratory experiments, new research data were obtained on the temporal specificity of the process of constructing a personal cognitive space in students. Using prognostic modeling procedures, we were able to record the presence of structural relationships between the time perception, cognitive characteristics of problem-solving, and stability of academic performance. It was experimentally proved that characteristics of time reaction and effectiveness in completing accuracy tasks and mental rotation tasks act as temporal predictors of levels of students’ academic performance. Discussion. The study revealed the fact that students with a dominant temporal orientation toward the present situation, looking constantly for new stimuli and feelings in the current time, had quite pronounced deficits in the choice of educational strategies based on more long-term and well-defined objective in the future. It was noted, as an important aspect in the personalization of studying, that students must be aware of their own temporal, cognitive and other characteristics of the information processing, and manage on their own their educational environments as appropriate. The possibilities are discussed in using cognitive diagnostic characteristics to predict and timely correct individual trajectories of students’ educational paths as part of the adaptive approach to education.
Adipokines: A Rainbow of Proteins with Metabolic and Endocrine Functions
Authors: Parrettini Sara , Cavallo Massimiliano , Gaggia Francesco , Calafiore Riccardo , Luca Giovanni
Published: May 2020

Obesity represents one of the most important health problems worldwide with increasing
morbidity and mortality. Widespread prevalence of this disease justifies its actual definition of
a “global epidemic”. Adipose tissue is nowadays considered a complex organ with lots of endocrine
and metabolic functions. In addition to fulfilling its task for energy storage and thermal regulation,
by virtue of its constituent white and brown cells, adipose tissue represents, considering its
size, the biggest endocrine gland in the body. Both adipocytes and surrounding resident cells
(macrophages, endothelial cells and others) produce a huge number of molecules, or adipokines,
with endocrine or paracrine functions, that regulate various aspects of metabolism whose clinical
relevance is emerging. By balancing pro-inflammatory and anti-inflammatory effects, the
adipokines control insulin sensitivity and related glucose metabolism changes, lipid accumulation
in the liver and other organs, and finally gonadal function. Collectively, literature data remains
cloudy because of still conflicting results of pre-clinical and clinical studies. The aim of this review
was to summarize scientific evidence about adipokines’ effects on human metabolism, by focusing
on their role on either Metabolic Syndrome and NAFLD, or insulin-resistance in pregnancy, or
finally, reproductive function disorders.
Identification of Novel Cytotoxic T Lymphocyte Epitopes of Drug- Resistance Related Protein InhA from Mycobacterium tuberculosis
Authors: Li Dezhi , Dou Zelong , Wu Yahong , Qi Yuanming , Chen Junhui , Gao Yanfeng
Published: May 2020

Background:

Tuberculosis (TB) caused by Mycobacterium tuberculosis (MTB), especially the drug-resistant MTB, poses serious challenges to human healthcare worldwide. Cytotoxic T lymphocytes (CTLs) play a vital role in immune defense against MTB.

Objective:

To identify novel CTL epitopes that could induce cellular immunity against MTB infections.

Methods:

The HLA-A*0201 restricted CTL epitopes of the drug-resistant protein InhA from MTB were predicted by online algorisms and synthesized by the Fmoc solid phase method. The candidate peptides were used to induce CTLs from human peripheral blood mononuclear cells (PBMCs) of HLA-A*0201 healthy donors and the HLA-2.1/Kb mice. IFN-γ productions of CTLs were detected by enzyme linked immunospot assay (ELISPOT), flow cytometry and enzyme-linked immunosorbent assay (ELISA), and cytotoxicity was analyzed by lactate dehydrogenase (LDH) assay.

Results:

A group of 4 epitopes were screened out with high affinities to HLA-A*0201. ELISPOT and flow cytometry analysis indicated these peptides significantly induced that IFN-γ release of CTLs from the HLA-A*0201+/PPD+ donors, as the mutant analogues had more potent stimulation effects. LDH assay showed that CTLs from PPD+ donors and the immunized mice exhibited significant cytotoxicity and low cross-reactivity. ELISA analysis revealed comparative levels of IFN-γ were released by CTLs isolated from the mice spleen.

Conclusion:

Our study has identified 4 novel CTL epitopes of InhA that could elicit potent CTL immunity, establishing a foundation for the development of multivalent peptide vaccines against the drug-resistant MTB.
Maternal Vitamin D and its Role in Determining Fetal Origins of Mental Health
Authors: Lisi Giulia , Ribolsi Michele , Siracusano Alberto , Niolu Cinzia
Published: May 2020

:

There is evidence that mental health disorders may have roots in fetal life and are associated with deficiencies in various micronutrients, including vitamin D. During pregnancy, vitamin D balance is influenced by an increase in maternal calcitriol and a substantial increase in maternal Vitamin D Binding Protein concentrations. In the early stages of life, vitamin D is necessary to mediate numerous brain processes such as proliferation, apoptosis, and neurotransmission. Furthermore, Vitamin D has a recognized anti-inflammatory activity that normally suppresses inflammation. Increased activation of hypothalamo-pituitary-adrenal axis (HPA) and inflammation during gestation may influence maternal health and fetal neurodevelopment during and beyond pregnancy. A deficit of Vitamin D and maternal stressful events during gestation, such as perinatal depression, could influence the efficacy of the immune system altering its activity.

:

Vitamin D deficiency during gestation associated with a reduction in fetal brain development has been widely described and correlated with alteration in the production of the brain-derived neurotrophic factor. To this regard, many studies highlights that low maternal vitamin D dosage during gestation has been related to a significantly greater risk to develop schizophrenia and other severe mental illnesses in later life. The objective of this paper is a comprehensive overview of maternal vitamin D balance in determining the fetal origins of mental health with some references to the link between vitamin D levels, inflammatory responses to stress and mental disorders in adult life.
Non-Vitamin K Antagonist Oral Anticoagulants in Pulmonary Embolism: An Overview of Systematic Reviews
Authors: Doundoulakis Ioannis , Antza Christina , Karvounis Haralambos , Giannakoulas George
Published: May 2020

Background:

Anticoagulation in patients with pulmonary embolism.

Objective:

To identify how non-vitamin K antagonist oral anticoagulants are associated with multiple outcomes in
patients with pulmonary embolism.

Methods:

We performed a systematic search of systematic reviews via multiple electronic databases from inception to August 19th, 2019, without language restriction. Two authors independently extracted data and assessed
the methodological quality of the included systematic reviews using the ROBIS tool.

Results:

We found twelve systematic reviews. Eleven SRs collected their data from randomized clinical trials and
one from observational studies. All the included studies were published between 2014 and 2019 in English. The
methodological quality of the 12 systematic reviews was low to high. None of the systematic reviews, which are
included in our overview of systematic reviews, has evaluated the overall quality of evidence outcome using the
Grading of Recommendations Assessments, Development and Evaluation (GRADE) approach.

Conclusion:

This is the first effort to summarize evidence about non-vitamin K antagonist oral anticoagulants in
an overview of systematic reviews focusing exclusively on patients with pulmonary embolism. The evidence
suggests that the non-vitamin K antagonist oral anticoagulants seem to be more effective and safer than a dualdrug approach with LMWH- VKA.
Effects of Enzymatic Hydrolysis Conditions on the Antioxidant Activity of Red Tilapia (Oreochromis spp.) Viscera Hydrolysates
Authors: Sepúlveda Cindy T. , Zapata José E.
Published: May 2020

Background:

Fish is an essential source of nutrients for human nutrition due to the composition
of proteins, vitamins, and minerals, among other nutrients. Enzymatic hydrolysis represents an
alternative for the use of by-products of the aquaculture industry.

Objective:

We propose to evaluate the effect of stirring speed, temperature, and initial protein concentration
on the degree of hydrolysis of proteins and antioxidant activity of red tilapia (Oreochromis
spp.) viscera hydrolysates.

Methods:

The effect of stirring speed, temperature, and initial protein concentration on the degree of
hydrolysis of proteins and antioxidant activity was evaluated using an experimental design that was adjusted
to a polynomial equation. The hydrolysate was fractioned to determine the antioxidant activity
of the fractions, and functional properties were also measured.

Results:

Stirring speed and protein concentration presented a statistically significant effect (p <0.05)
on all the response variables. However, the temperature did not present a statistically significant effect
on the degree of hydrolysis.

Discussion:

The best conditions of hydrolysis were stirring speed of 51.44 rpm, a temperature of
59.15°C, and the protein concentration of 10 g L-1. The solubility of the hydrolysate protein was high
at different pH, and the hydrolysate fraction with the highest antioxidant activity has a molecular
weight <1 kDa.

Conclusion:

The degree of hydrolysis and the biological activity of red tilapia viscera hydrolysates
(Oreochromis spp.) are affected by temperature, substrate concentration, and stirring speed. The optimal
conditions of hydrolysis allowed to obtain a hydrolysate with antioxidant activity are due to the
peptides with low molecular weight.
Neoadjuvant Chemotherapy Induces the Appearance of New Copy Number Aberrations in Breast Tumor and is Associated with Metastasis
Authors: Litviakov Nikolai V. , Ibragimova Marina K. , Tsyganov Matvey M. , Doroshenko Artem V. , Garbukov Eugeniy Y. , Slonimskaya Elena M.
Published: May 2020

Background:

In this study, we examined the CNA-genetic landscape (CNA – copy number
aberration) of breast cancer prior to and following neoadjuvant chemotherapy (NAC) and correlated
changes in the tumor landscape with chemotherapy efficiency as well as metastasis-free survival.

Objective:

Breast cancer patients (n = 30) with luminal B molecular subtypes were treated with anthracycline-
based therapy.

Methods:

To study CNAs in breast tumors, microarray analysis was performed.

Results:

Three effects of NAC on tumor CNA landscape were identified: 1 – the number of
CNA-bearing tumor clones decreased following NAC; 2 – there were no alterations in the
number of CNA-containing clones after NAC; 3 – the treatment with NAC increased the number
of CNA-bearing clones (new clones appeared). All NAC-treated patients who had new tumor
clones with amplification (20%) had a 100% likelihood of metastasis formation. In these cases,
NAC contributed to the emergence of potential metastatic clones. Our study identified the
following loci – 5p, 6p, 7q, 8q, 9p, 10p, 10q22.1, 13q, 16p, 18Chr and 19p – that were amplified
during the treatment with NAC and may be the markers of potential metastatic clones. In other
patients who showed total or partial elimination of CNA-bearing cell clones, no new
amplification clones were observed after NAC, and no evidence of metastases was found with
follow-up for 5 years (р = 0.00000).

Conclusion:

Our data suggest that the main therapeutic result from NAC is the elimination of potential
metastatic clones present in the tumor before treatment. The results showed the necessity of an
intelligent approach to NAC to avoid metastasis stimulation.
Characteristics of Patients with Hypopituitarism having Onset Symptoms of Pseudo-Intestinal Obstruction: A Case Report
Authors: Yuan Ning , Chai Sanbao , Sun Jianbin , Liu Yufang , Xin Sixu , Zhang Xiaomei
Published: May 2020

Background:

Gastrointestinal symptoms are often the first symptoms of hypopituitarism.
However, pseudo-intestinal obstruction is not a common manifestation of hypopituitarism. Some patients
presenting with gastrointestinal symptoms as their chief complaint were admitted to the Department
of Gastroenterology and were accurately diagnosed with hypopituitarism at the Department of
Endocrinology.

Case Summary:

This case pertains to a 57-year-old man with poor appetite, fatigue, weakness, and
recent onset recurring abdominal pain. An erect, abdominal X-ray indicated flatulence and gas-fluid
levels in the midsection of the abdomen, and pseudo-intestinal obstruction was diagnosed. Subsequently,
the patient was referred to the Department of Gastroenterology to identify the cause of the
pseudo-intestinal obstruction. An examination of the digestive system did not reveal any abnormalities,
but the patient developed hyponatremia and exhibited drowsiness. The patient was transferred to the
Department of Endocrinology for further treatment. The patient was eventually diagnosed with hypopituitarism,
caused by empty sella syndrome. The patient received prednisone and euthyrox replacement
therapy, and pseudo-intestinal obstruction did not occur again.

Conclusion:

In general, endocrine diseases, including hypopituitarism, hypothyroidism, and hyponatremia,
should be considered for patients with pseudo-intestinal obstruction combined with hyponatremia
and drowsiness, especially if the symptoms of the digestive system are not complicated and the
drowsiness is obvious.
Oral Alpha Lipoic Acid Treatment for Symptomatic Diabetic Peripheral Neuropathy: A Randomized Double-Blinded Placebo-Controlled Study
Authors: El-Nahas Mamdouh R. , Elkannishy Ghada , Abdelhafez Hala , Elkhamisy Enas T. , El-Sehrawy Amr A.
Published: May 2020

Background:

Alpha-lipoic acid (ALA) was used in the treatment of diabetic peripheral neuropathy
(DPN) using different routes, doses and treatment durations. The aim of this work is to assess
the efficacy of oral 600mg ALA twice daily over 6 months in the treatment of patients with DPN.

Methods:

This is a prospective, single-center, double-blinded, placebo-controlled study conducted at
the outpatient clinic of Mansoura Specialized Hospital, Mansoura University. A total of 200 patients
with DPN were randomly assigned to add on treatment with either oral 600mg twice daily ALA
(n=100) or placebo (n=100) for 6 months. Treatment outcome was assessed using vibration perception
threshold (VPT), neurological symptom score (NSS), neurological disability score (NDS), and visual
analog scale (VAS) for pain at baseline and at each visit (1, 3 and 6 months) after the start of treatment.

Results:

Comparison between the study groups regarding the baseline data revealed no statistically
significant differences. with respect to the outcome parameters, no significant differences were found
between the studied groups at baseline. However, in subsequent visits, ALA-treated patients had significantly
better results regarding almost all the outcome parameters (NSS, NDS, VAS, VPT). Mild
nausea was reported in 6 patients. None of the studied patients discontinued treatment.

Conclusions:

Oral 600mg ALA twice-daily treatment for DPN over 6 months is effective, safe and
tolerable.
Association Between sRAGE and Arterial Stiffness in Women with Systemic Lupus Erythematosus
Authors: Wang Hongru , Zeng Yibin , Zheng Huan , Liu Bin
Published: May 2020

Background:

sRAGE (soluble receptor for advanced glycation end products) is known to
play a protective role in chronic inflammatory diseases, and has been found to be related to arterial
stiffness in hypertensive or diabetic patients. This cross-sectional study was designed to study the potential
association of sRAGE with arterial stiffness in systemic lupus erythematosus(SLE) patients.

Methods:

A total of 94 female SLE patients were enrolled. Brachial-ankle pulse wave velocity
(baPWV) was measured by an automatic pulse wave analyzer. The patients were divided into two
groups according to the baPWV values, those with values greater than 1400cm/s were placed in the
high arterial stiffness group. Biochemical parameters were compared between the two groups. Linear
and logistic regression analysis was used to observe the association between sRAGE and arterial stiffness
in these patients.

Results:

Thirty-five patients were placed in the high arterial stiffness group in which sRAGE levels
were lower (P<0.05). sRAGE levels were significantly related to baPWV(standardized β=1.18,
P<0.01) by linear regression analysis. Multivariate logistic regression analysis showed that sRAGE,
SLE duration, systolic blood pressure, and low-density lipoprotein cholesterol were independent predictors
of arterial stiffness in these patients.

Conclusion:

The results revealed that sRAGE was negatively associated with arterial stiffness in Chinese
female SLE patients.
Correction: Preventive Behaviors Conveyed on YouTube to Mitigate Transmission of COVID-19: Cross-Sectional Study (Preprint)
Authors: Basch Corey H , Hillyer Grace C , Meleo-Erwin Zoe C , Jaime Christie , Mohlman Jan , Basch Charles E
Published: May 2020

INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID)

RR2-10.2196/18807
Severity Model Based Prediction of Early Trend and Pattern Recognition of the COVID-19 Infection in India: Exploratory Data Analysis and Machine Learning Study (Preprint)
Authors: Khan Afreen , Zubair Swaleha
Published: May 2020

UNSTRUCTURED

Objective: Recent Coronavirus Disease 2019 (COVID-19) pandemic has inflicted the whole world critically. Despite the fact that India has not been listed amongst the top ten highly affected countries, one cannot rule out COVID-19 associated complications in the near future. The accumulative testing facilities has resulted in exponential increase in COVID-19 infection cases. In figures, the number of positive cases have risen up to 33,614 as of 30 April, 2020. Keeping into consideration the serious consequences of pandemic, we aim to establish correlations between the numerous features which was acquired from the various Indian-based COVID datasets, and the impact of the containment of the pandemic on the current state of Indian population using machine learning approach. We aim to build the COVID-19 severity model employing logistic function which determines the inflection point and help in prediction of the future number of confirmed cases.
Methods: An empirical study was performed on the COVID-19 patient status in India. We performed the study commencing from 30 January, 2020 to 30 April, 2020 for the analysis. We applied the machine learning (ML) approach to gain the insights about COVID-19 incidences in India. Several diverse exploratory data analysis ML tools and techniques were applied to establish a correlation amongst the various features. Also, the acute stage of the disease was mapped in order to build a robust model.
Results: We collected five different datasets to execute the study. The data sets were integrated extract the essential details. We found that men were more prone to get infected of the coronavirus disease as compared to women. Also, the age group was the middle-young age of patients. On 92-days based analysis, we found a trending pattern of number of confirmed, recovered, deceased and active cases of COVID-19 in India. The as-developed growth model provided an inflection point of 85.0 days. It also predicted the number of confirmed cases as 48,958.0 in the future i.e. after 30th April. Growth rate of 13.06 percent was obtained. We achieved statistically significant correlations amongst growth rate and predicted COVID-19 confirmed cases.
Conclusion: This study demonstrated the effective application of exploratory data analysis and machine learning in building a mathematical severity model for COVID-19 in India.
A NEW VALIDATED THIRD ORDER DERIVATIVE SPECTROSCOPIC METHOD FOR SIMULTANEOUS ESTIMATION OF METOPROLOL SUCCINATE AND RAMIPRIL IN TABLET DOSAGE FORM
Authors: B. ALEKHYA , SINDHUSHA M. , RAUL SORAJ K. , PADHY GOPAL K.
Published: May 2020

Objective: The objective of the present work is to develop and validate a new UV derivative spectrophotometric method for simultaneous estimation of metoprolol succinate and ramipril in methanol: water (50:50v/v).

Methods: “Zero crossing technique” was chosen for quantitative determination. The zero-crossing points (ZCP’s) were found to be 209 nm where metoprolol succinate was quantified and 211 nm where ramipril was quantified. This method was then subjected to accuracy, linearity, sensitivity and reproducibility according to ICH guidelines to ensure and confirm its validity.

Results: The method was found to be obeying Beer’s law in the range of 10-50 µg/ml and 5-25 µg/ml for metoprolol succinate and ramipril, respectively. The % recoveries were observed between the range of 99.2-100.2 for metoprolol succinate and 99.57-99.86 for ramipril. The intra-day and inter-day results showed reproducibility.

Conclusion: It can be concluded that the developed third-order UV derivative spectroscopic method for the simultaneous determination of metoprolol succinate and ramiprilcan be recommended for routine quantitative analysis.
The THE ROLE OF PLATELET RICH PLASMA AND QUERCETIN IN ALLEVIATING DIMETHYLNITROSAMINE-INDUCED ACUTE SPLEEN INJURY THROUGH REGULATING OXIDATIVE STRESS, INFLAMMATION AND APOPTOSIS
Authors: ZAAZAA ASMAA M. , ANISS NADIA NOBLE-DAOUD
Published: May 2020

Objective: Excessive oxidative stress is implicated in spleen injury. Platelet-rich plasma (PRP) and quercetin (QUR) have been shown to protect cells against oxidative stress. This study was designed to investigate their effect on dimethyl nitrosamine (DMN) induced spleen injury in male rats.

Methods: Forty male Wistar rats were divided into four groups; Group (1): Negative control group (Con), Group (2): DMN group, DMN was given intraperitonealy at a dose of 4 mg/kg b. wt/day for four weeks for sub-chronic injury of spleen tissue, Group (3): DMN+PRP, rats were injected intraperitonealy with DMN at a dose of 4 mg/kg b. wt/day for four weeks then treated i. v. by single dose 50 μL of PRP, then left for a period of four weeks without any treatments, Group(4): DMN+QUR, rats received intraperitonealy DMN at a dose of 4 mg/kg b. wt/day for four weeks, then treated with quercetin orally at a dose of 50 mg/kg b. wt. in aqueous suspension daily using an intragastric tube for four weeks.

Results: DMN inoculation resulted in significant elevations of oxidative stress, as evidenced by the increased malondialdehyde, hydrogen peroxide and xanthine oxidase levels associated with a significant decrease in Superoxide dismutase and catalase activities in the spleen tissue as compared to the normal control group. Moreover, DMN caused an up-regulation in the values of the splenic C-reactive protein (CRP), interleuckin-6 (IL-6), nuclear factor kappa B (NF-κB), leukotriene-C4 (LT-C4), P53 and Fas levels with a significant decline in anti-apoptotic protein B-cell lymphoma 2 level as compared to the normal control group. PRP and QUR significantly attenuated the DMN-evoked spleen oxidative stress and modulated the activities of antioxidant enzymes as compared to DMN group. In addition, treatment of DMN group with PRP or QUR resulted in an improvement in CRP, IL-6, NF-κB, LT-C4, P53 and Fas levels as compared to DMN group. Caspase-3 expression was positive in DMN group while no difference was present in control, PRP and Quercetin groups. However, the VEGF immunopositive reaction was found in DMN, PRP and Quercetin groups compared to control group. Histopathological results showed degeneration, haemorrhage, inflammatory cells and necrotoic areas in splenic tissue from DMN group compared to the treated groups where signs of recovery were observed in the whole splenic tissue.

Conclusion: These data suggest that PRP and QUR protect rat spleen from DMN-induced oxidative stress, probably via their antioxidant activity, anti-inflammatory and anti-apoptotic effects. So, PRP and QUR are promising pharmacological agents for preventing the potential spleen injury of DMN following occupational or environmental exposures.
KORUPCIJA KAO OBLIK UGROŽAVANJA LJUDSKE BEZBEDNOSTI: POLITIČKA, EKONOMSKA I ZDRAVSTVENA DIMENZIJA
Authors: Filijovic Marko , Djordjevic Ivica
Published: May 2020

Korupcija se u fokusu ovog rada nalazi zbog svojih efekata na funkcionisanje zajednice i kvalitet života njenih članova. Ona predstavlja globalni bezbednosni problem, jer se ispoljava u svim državama savremenog sveta bez obzira na njihov nivo razvoja i demokratske tradicije. Postoje određene varijacije u odnosu na efekte korupcije što zavisi od snage države i njenih institucija da se obračunaju sa ovom negativnom pojavom. Razvijene zemlje nisu imune na korupciju, ali u njima postoje funkcionalni mehanizmi koji je drže pod kontrolom. Korupcija se najviše ispoljava u sistemima koji su u funkciji zadovoljavanja javnih interesa. Koncept ljudske bezbednosti predstavlja dobar analitički okvir koji može da doprinese utvrđivanju nivoa korupcije, njenim efektima i uzrocima. U radu smo izabrali tri dimenzije ljudske bezbednosi koje najbolje otslikavaju uzroke i posledice koruptivne prakse. Na osnovu rezultata istaživanja može se reći da postoje određeni uzročno-posledični odnosi između karaktera političkog sistema i ekonomskih prilika koji pogoduju razvoju korupcije. Najznačajnija posledica korupcije je smanjenje javnih fondova što se najdrastičnije manifestuje u funkcionisanju zdravstvenog sistema.
SPOLJNA POLITIKA EVROPSKE UNIJE U TEORIJSKOM KONCEPTU STRUKTURNE SPOLJNE POLITIKE
Authors: Stankovic Nevena
Published: May 2020

Evropska unija je sistem spoljnih politika ali i globalni činilac međunarodnih odnosa, koji u poslednjih trideset godina razvija sopstvenu spoljnu politiku. Ova politika EU, najartikulisaniji vid dobija u vidu Zajedničke spoljne i bezbednosne politike, pa danas imamo međusobni odnos struktura EU i ZSBP, kao važan činilac funkcionisanja institucionalnog sistema EU. Veliki broj učesnika na unutrašnjem i spoljašnjem planu, kako u stvaranju tako i u sprovođenju ZSBP, otežava da se njene glavne institucionalne i političke karakteristike najbolje razumeju uz pomoć tradicionalnih teorija međunarodne politike. Nakon osvrta na ključne postavke tradicionalnih teorijskih pravaca u izučavanju spoljne politike EU, u radu će biti predstavljen teorijski koncept strukturne spoljne politike. Ovakav izbor teorijskog gledišta polazi od teze da globalizacija kao politički kontekst, nudi novu perspektivu spoljne politike, koja ima važne implikacije za njeno razumevanje i proučavanje. Prema definiciji, strukturna spoljna politika teži da utiče ili oblikuje političke, pravne, društveno-ekonomske, bezbednosne i psihološke strukture. Ove strukture odlikuje ne samo države i međunarodne odnose, već i društva, položaj pojedinca, odnos između države i društva i međunarodnog sistema u celini. U radu će, na primeru Evropske unije, biti pokazano kako se konceptualni okvir strukturne spoljne politike primenjuje za analizu političke stvarnosti.
Analytical ruled surfaces and their complete classification
Authors: Krivoshapko Sergey N.
Published: May 2020

The aim of the work - to give the possibility to expand mind of designers and architects projecting structures in the form of traditional and non-canonical ruled surfaces. These surfaces have several unquestionable advantages with a point of view of their forming, designing, and making of factory-made goods and erections in the form of ruled surfaces and analysis methods. Methods. Choosing ruled surfaces for classification, one can use methods of their determination by vector, parametrical, implicit, and in explicit equations. Only analytical ruled surfaces are considered which were examined and presented in scientific-and-technical literature. Results. All known at present time ruled surfaces are given in a graphic form. The determinations of some little known ruled surfaces are presented in a paper. The original sources, where these surfaces are examined or their application in real structures and erections are considered, or methods of determination of stress-strain state in thin-walled shells with ruled middle surfaces are presented, are given in references.
“Keep silence to poetry”: “silence” in M.S. Petrovykh’s life and writing
Authors: Mengjiao Wang , Ponomareva Tatiana A.
Published: May 2020

The motive and image o “silence” in M.S. Petrovykh’s lyrics is connected with her poetic worldview, understanding of the creative nature and social reality. Image “silence” defines the lyrical plot of the conceptual poem “One thing I want to say to poets...”. The poem reveals the type of creative and life behavior that the author professes. One the basis of some biographical facts of M. Petrovykh, which are confirmed in verse, the lexical and semantic level of poems in which the image and motive “silence” are presented is analyzed in this paper. “Silence” was the theme not only of M. Petrovykh, A. Akhmatova, but also of other writers of the era of the 1930s and 1950s, which is due to the atmosphere of the time. External and internal censorship dictated the style of behavior. But the poet must get to the hard core of what is happening and recreate the true reality, write the truth. The meaning of “keep silence to poetry” is precisely this. This is not just an aphorism, but the meaning of genuine creativity.
Indian social media politics: new era of election war
Authors: Patel Keshav , Binjola Himani , Siddiqui Taha
Published: May 2020

The role of social media during 16th Lok Sabha elections has led to several insights in the manner in which the youth of today is consuming political news. Several social media platforms have played a significant role in voting behaviour. Social media platform acted as a game changer and a catalyst in wooing young voters and influencing their opinion. While Internet users grew 7% in Urban India reaching 315 million users in 2018, digital adoption is now being propelled by rural India, registering a 35% growth in Internet users over the past year. Also, there have come a general perception that television will play a lesser role in this upcoming election and digital media will play a never before seen influence on voters. This research examines the behaviour of youth in India and examines the level of influence by social media in casting their vote in Lok Sabha elections. Whether social media can be a game changer or an influencer. These findings will be carried out by this research work.
“The winter of history came suddenly...”: the concept of time in the poems of Victor Krivulin
Authors: Khairulin Timur P.
Published: May 2020

The article is devoted to the problem of historicism in the texts of the Leningrad unofficial poet and critic Viktor Krivulin. The novelty of the study is an attempt to consider the poetic historiosophy of Krivulin in the context of the “religious revival” of the 1970s in the USSR. This approach allows us not only to determine the specifics of the images of time in the works of Krivulin, but also to outline the contours of the intellectual history of Soviet unofficial culture. Special attention is paid to eschatological motives in Krivulin's works, as well as to the opposition of the “horizontal” and “vertical” types of time. Everyday reality, with its measured course of events subordinated to the chronological order, is overcome in Krivulin's texts by entering the sacred sphere of culture, where creative dialogue with literary predecessors is endowed with a special value status. It was cultural co-creation that allowed the unofficial poet to go beyond the static late Soviet experience and rediscover his identity. The images of time in Krivulin's texts are associated with Christian eschatology, which assumes the finality of historical existence. This was most clearly manifested in the transformation of the image of Leningrad, which appeared in the works of Krivulin as a “ghost town”, in which history stopped.
Why has sci-fi literature lost its popularity in Azerbaijan after 1990?
Authors: Alasgarova Gunel
Published: May 2020

This paper examines the reasons why science fiction works are not popular in the last decades in Azerbaijan. The focus of this research is to determine whether there is a lack of science fiction novels in the market or low-quality of existing modern novels that leads to the unpopularity in the society. The data collection methods were conducting a survey among people and several interviews of literature experts. Libraries and bookshops, as well as school literature textbooks, were observed in the search of science fiction works, as well. The survey identified the reasons for the unpopularity of science fiction and the role of authors, works, libraries, and bookshops in this trend. The findings of the survey indicate that people still read and are involved in this genre and strongly prefer world classics rather than national. While observing Azerbaijan National Library, it was found out that in modern Azerbaijan literature there are enough books in this genre, which are not properly promoted by bookshops, social media, TV programs or school textbooks. Whereas, experts in this field indicated that the newly published novels are not engaging or appealing enough to be bought by a large audience. Additionally, it would be useful to include that science fiction is losing its prestige to the fantasy all over the world, including Azerbaijan. These results partially support earlier articles that describe science fiction as an unpopular genre in Azerbaijan in the XXI century, whereas this research claims that there are readable works, which need for more advancement.
Modern Russian Studies in Kazakhstan: Professor E.D. Suleimenova (Devoted to 75th Birth Anniversary)
Authors: Agmanova Atirkul Egemberdievna , Temirgazina Zifa Kakbaevna
Published: May 2020

The article is timed to coincide with 75th anniversary of Eleonora Dyusenovna Suleimenova, who is a famous scientist of Kazakhstan, Doctor of Philology, academic of International Higher Education Academy. The contribution of E.D. Suleimenova to the development of modern linguistics is considered in the context of her basic multifaceted scientific, educational and social activities. A special attention is paid to the academic’s fundamental works in General and Contrastive Semantics, Sociolinguistics and Theory of Second Language Acquisition. In the present article some practical research results of Suleimenova have been discussed, those of theoretical foundation of lexicographic principles of metalinguistic units and their realization in two language dictionaries, compiled by her guidance (“Glossary in Linguistics”, Languages of peoples of Kazakhstan” Reference book, “Business Language: Kazakh-Russian Dictionary of collocations”, “Glossary of Sociolinguistic terms”). Some other linguistic and educational ideas of the scientist that have been reflected in the textbooks for both school and university students have also been viewed.
Semantic Continuumof Myth
Authors: Vladimirova Tatyana E.
Published: May 2020

Language, the first cultural phenomenon, received textual expression in myths, of which the oldest tell of the mystical relationship of the tribe with the animal. Consideration of the concepts that arose on this basis, and then of “conceptual myths” (OM Freidenberg) about the totem-ancestor makes it possible to analyze their semantic-semantic fields. Moreover, we relied on the cultural-historical concept of G.G. Shpet, which allowed us to trace the evolution and subsequent transformation of the semantic-semantic fields of myth and thus reveal the algorithm for the formation of the mythopoetic tradition, its fading and eternal return. In the center of this work is semantic-semantic fields of myths about the Heavenly deer / moose cow, the cult which stretched over the more than six millennia. Observing the astral objects that served as a spatial-temporal reference point in the hunting and reindeer herding, primitive tribes felt their unity with the star ancestors. For example, two constellations of seven stars, which served the primitive hunters and reindeer breeders as a guide on the way, began to be identified in the russian North with the horned Reindeer Mother / moose cow and her daughter, from which the well-being of people depends. The attempt of comparative-historical reconstruction of semantic-semantic fields in article based on the material of myths about totems-forefathers made it possible to distinguish three main layers. These are 1) the energetically “charged” field of the myth of the shaman visiting the fantastic deer in labor, in which the religious and mythological consciousness received expression; 2) a semantic-semantic field of myths that belong to the artistic and heroic consciousness and narrate about a cultural hero who is ready for a feat for his family-tribal community; 3) the semantic-semantic field of the myth of the Horned mother-deer in the story of Ch. T. Aitmatova’s “White Steamboat (After the Tale)”, the rescue of orphans who became the ancestors of the Bugu tribe (‘deer’), and contains deep thoughts of the author, the bearer of cultural-historical and philosophicalcultural consciousness. As for the semantic-semantic fields, specific to the various interpretations of plots about a moose cow and a calf, close to a household fairy tale, a hunting story and a joke, so they correspond to the scientific and technical type of consciousness that has lost its connection with myth.
Structural-Semantic Modeling in Phraseology: Forty Years of Experience and the Prospects
Authors: Nikitina Tatiana G.
Published: May 2020

The purpose of this article is to analyze the experience gained in the field of structural-semantic modeling by domestic and foreign phraseologists working in the mainstream of the scientific school of V. M. Mokienko, the founder of this method, and to present prospects of the method applied to a dynamic system of modern phraseology. The relevance of addressing this issue is determined by the high linguo-cultural and linguo-didactic potential of phraseological modeling, the need to identify opportunities for its use in the study of phraseological layers that have not yet been fully developed. Using the descriptive method to process the data presented in the works on structural-semantic modeling, the author summarizes the results obtained by phraseologists for four decades of active use of the method in historical, etymological and linguoculturological research. The scope of the method’s application to the material of different languages, the breadth of the research spectrum in terms of synchrony/ diachrony is emphasized: from the reconstruction of phraseology at the level of the protolanguage to the modeling of phraseological units-neologisms. The research material was not only scientific sources, but also language material: phraseology of Russian folk dialects, modern urban speech and Internet communication. Using the method of structural-semantic modeling in relation to these phraseological layers, the author demonstrates the possibility of identifying generating models of formation and transformation of phraseological units, which until recently was considered impossible. For the first time, the method of structural-semantic modeling is also considered as one of the phraseographic techniques implemented by V. M. Mokienko and his followers in the field of academic and educational lexicography. Thus, the review of scientific sources presented in the article and the results of the author’s own research prove the productivity of the method of structural-semantic modeling, confirm its relevance and broad prospects in the study of Russian phraseology.