bluuebunny/crossref_metadata_2025 huggingface dataset:
Mouse Model of Low-density Lipoprotein Desialylation In Vivo
Authors: Kashirskikh Dmitry , Chicherina Nelya , Glanz Victor , Orekhov Alexander , Sobenin Igor
Published: June 2024

Background:

Atherosclerosis is a chronic disease characterized by the increased
infiltration and retention of LDL particles in arterial walls. There are several
mechanisms underlying atherogenesis, with the pro-atherogenic modifications of LDL
playing a significant role. One such modification of native LDL is desialylation, which
is characterized by the removal of terminal sialic acid from ApoB-100 glycans that induces
critical changes in the overall functionality of the LDL particle.

Aims:

The aim of this study was to model the desialylation of native LDL in mice, resembling
a phenomenon previously observed in atherosclerotic patients.

Objective:

LDL desialylation was induced in C57BL/6J mice via the injection of exogenous
neuraminidase. The degree of LDL desialylation and its duration were assessed.
The impact of LDL desialylation on blood lipid levels was evaluated. Furthermore, the
morphological alterations in the aorta during LDL desialylation in the bloodstream were
examined.

Method:

The control group of C57BL/6J mice received saline injections, while the experimental
group underwent a single injection of IgG-conjugated Vibrio cholerae neuraminidase.
The LDL sialic acid levels were assessed 1-7 days post-injection using the
Warren method and normalized to total protein content measured via the Lowry method.
A similar protocol was followed for the subchronic administration of the IgG-neuraminidase
conjugate over a 6-week period. The blood lipid profiles were analyzed using commercial
kits. The atherosclerotic plaque burden in the mouse aorta was quantified using
Oil Red O and hematoxylin-eosin staining.

Result:

A single administration of 20 mU IgG-neuraminidase conjugate resulted in decreased
LDL sialic acid levels for 5 days, gradually recovering by days 6-7. Subchronic
administration maintained reduced LDL sialic acid levels for up to 2 months. Notably,
sustained LDL desialylation was associated with elevated LDL cholesterol levels.

Conclusion:

A sustained desialylation of LDL in C57BL/6J mice was achieved through
subchronic administration of IgG-conjugated neuraminidase. This study provides an approach
for sustained LDL desialylation in mice. Further studies using apolipoprotein E
knockout mice and LDL desialylation will reveal the role of this process in the occurrence
and development of atherosclerosis.
Impact of Urinary Tract and Vaginal Infections on the Physical and Emotional Well-being of Women
Authors: Ojha Smriti , Vishwakarma Pratik Kumar , Mishra Sudhanshu , Tripathi Shivendra Mani
Published: June 2024

:

Urinary Tract Infection (UTI) is a common bacterial infection that can affect various
parts of the urinary system, with symptoms including frequent urination, painful urination,
and lower back pain. UTIs are more common in women due to their shorter urethra, and
they can lead to serious complications if left untreated. Vaginitis is an inflammation or infection
of the vagina caused by factors like bacteria, fungi (Candida), or protozoa (Trichomonas).
Symptoms include vaginal itching, abnormal discharge, and discomfort during urination
or sexual activity. Treatment depends on the underlying cause and may involve antifungal
or antimicrobial medications. Vaginal infections, such as bacterial vaginosis, yeast infections,
trichomoniasis, cervicitis, and atrophic vaginitis, can have various physical, emotional,
sexual, and social impacts on the lives of women. These impacts may include discomfort,
embarrassment, reduced sexual satisfaction, social isolation, and emotional distress. Support
and resources for managing these infections include healthcare providers who can diagnose
and prescribe treatment, pharmacies that provide medications and guidance, telemedicine for
remote consultations and prescriptions, support groups for emotional and informational support,
and online resources for reliable information. They offer a sense of community, information
sharing, and emotional support, making it easier for individuals to manage their vaginitis
and related concerns. Utilizing these resources can contribute to a more informed and
empowered approach to vaginal infection prevention and treatment.
Metabolic and Growth Outcome of Two-year Growth Hormone Treatment
in Children Born Small for Gestational Age: A Retrospective Study
Authors: Savanelli Maria Cristina , Ferrigno Rosario , Cioffi Daniela , Pellino Valeria , Klain Antonella
Published: June 2024

Background::

Children born Small for Gestational Age (SGA) without early catch-up
growth may show impaired growth rate, adult height, and metabolic profile [1]. Growth Hormone
(GH) is recommended for their treatment, and it has been shown to have positive effects
on growth and metabolic profile and good tolerability [2].

Objective::

The study aimed to evaluate the auxological and metabolic effects and safety of GH
treatment in SGA children.

Methods::

34 SGA children (15 F, 19 M; mean age: 8.72 ± 2.48 yrs) treated with GH (starting
dosage: 32.24 ± 2.88 mcg/kg/die) were evaluated every six months for 24 months with growth
and metabolic parameters.

Results::

After two years, SGA children showed a significant improvement in height, weight,
and growth rate, already evident after six months (p < 0.001), with a constant, significant improvement
in height throughout the treatment (p ≤ 0.03 T0 vs. T12, T12 vs. T24). Conversely,
although significantly higher than baseline at each visit (p < 0.001), the growth rate significantly
decreased from 6 to 18 months (p ≤ 0.015 T6 vs. T12, T12 vs. T18). During the follow-up, an
increase in glycemia (p ≤ 0.042 vs. T12, T18) and urycemia (p ≤ 0.01 vs. T12, T18, and T24)
and a decrease in AST (p ≤ 0.021 vs. T12, T18, and T24) and LDL cholesterol (p = 0.03 vs.
T24) were observed. Overall, treatment was found to be well tolerated, with poor compliance
being the most frequent adverse event (11.8%) and no reported hyperglycemia.

Conclusion::

In conclusion, GH can be considered an effective, safe treatment in SGA children,
improving height and growth rate, although proper metabolic follow-up is required.
Relationship between Self-management and Quality of Life among Patients with Diabetes Mellitus: A Cross-Sectional, Correlational Study
Authors: Al Gamal Ekhlas , Alnaser Zahra , Mohammed Isra , Kaliyaperumal Logapriya , AL Qudah Amal , Hyarat Saba , Alawas Haneen , Alrashed Jawharah , Alhamad Almaha , Long Tony
Published: June 2024

Background

Diabetes is managed by prescribed medication and dietary measures to control blood sugar, but self-management is a vital aspect of this management. Self-management is a complex bio-psycho-social phenomenon, a crucial task in monitoring the negative consequences of the condition and enhancing quality of life.

Objective

This study aimed to examine the relationship between self-management and health-related quality of life among Saudi patients with diabetes.

Methods

A descriptive, cross-sectional, comparative study design was adopted. Self-reported questionnaires were administered to 87 Saudi patients with diabetes in 2021. Data were analysed using Pearson’s r and t-test.

Results

The total adherence mean of diabetes self-care activities was 2.84 (SD=1.83), which is considered inadequate. The mean score for the total health-related quality of life was 57.35 (SD=15.01), which is regarded as fair. Patients with higher physical and social quality of life reported more adherence to self-management activities. Older patients generally experienced poorer quality of life. Patients with higher body mass index reported statistically significantly more body pain. Male patients reported higher total quality of life and role functioning. Females reported more body pain than males.

Conclusion

Diabetic patients have particular challenges in controlling the disease. Nurses and other healthcare providers need to empower patients to engage in culturally appropriate self-management and physical exercise. The results reported here could be used to design a specific health promotion policy that addresses the promotion of physical exercise and self-management of diabetes care. These policies should consider cultural nuances and be tailored to different demographic groups.
Personalized Medicine (PM) A Critical Appraisal
Authors: Raza Syed Tasleem , Rizvi Saliha , Ouhtit Allal , Ali Farhan , Ali Sher
Published: June 2024

Personalized medicine, also referred to as precision medicine, deals with a
clinical model that delineates patients into different groups based on their ethnicity,
lifestyle, food habits, medical history, drug reaction, comorbidity, the robustness of the
immune system, age, gender, and proneness to infection, overall psyche and attitude
towards life. Further, emotions, social interactions and life experiences culminating
into overall happiness play an important role in the life of a person. Thus, an
emotionally strong and happy person is usually healthy. Taking all these above factors
into consideration and with accurate diagnosis, a drug may be prescribed more in tune
with the uniqueness of the patient’s genome. Since everybody, whether diseased or
healthy, has a unique genome, this uniqueness must be utilized in deciding the drug,
dose and its long-term effects. Healing and cure should address the root cause of the
problem instead of working only on the symptoms to provide short-term relief. In
addition, repurposing of the drug which is not an old concept should also be carefully
explored because with this approach, a large number of already available drugs may be
used for a much wider number of diseases than the medicine originally developed for.
This will also help reduce the cost of the development of medicine. Finally, clinicians
and doctors should be sensitized to the concept of precision medicine and its less
obvious sub-disciplines. This is envisaged to provide better, more accurate diagnosis
and may result in better treatment. The medical field, besides being a deep science is
also an art starting from how to deal with diverse types of patients of different
backgrounds and educate them all the way to instill a sense of confidence and then to
prescribe the medicine to cure the disease. Seemingly, within the realm of precision
medicine, it is a huge task. However, it is possible to collect and analyze diagnostic
data to reach a consensus. This would require the involvement of clinical psychologists
and genetic counselors in a hospital setting ensuring that patient care is holistic, taking into account both the physical and psychological aspects of health. This integrated
approach can lead to improved patient care and long-term well-being.
Prevalence of Triple Negative Breast Cancer and its Therapeutic Challenges
Authors: Maqbool Mir Shahid , Anand Loveleena Kour , Malik Fayaz
Published: June 2024

Breast cancer (BC) is the most common among females. The current status
of BC worldwide shows that more than 1 million women are affected and ~400 000 die
every year. Partial success has been achieved by mammography coupled with adjuvant
treatment. However, its incidence and mortality both are increasing. Several subcategories of BC have been reported; of which, one is triple-negative breast cancer
(TNBC). This is defined by a lack of expression of oestrogen and progesterone
receptors and human epidermal growth factor receptor 2 (HER-2). Several approaches
have been used for speedy and accurate diagnosis and precise treatment of BC. In this
context, precision medicine approach is of great relevance in ameliorating the suffering
of the patient’s from the menace of BC. The present chapter aims to provide
background information, different types of BC and its sub-types and molecular
mechanisms for therapeutic intervention required for precision medicine.
Circadian Clock Modulation: A Novel Therapeutic Approach to Cancer Treatment and Management
Authors: Sultan Armiya , Fakhri Khalid Umar , Sultan Tahira , Khan Mohd Yasir , Ali Sher
Published: June 2024

There is a time code to the genome instructing temporal regulation of
cellular activities. The time code is expressed in the form of circadian clocks composed
of many transcription, co-activator, and co-repressor factors. The transcriptiontranslation feedback loops generated collectively by these factors regulate daily ~24-
hour rhythms in physiology, metabolism, and behavior across divergent phyla.
Genome-wide studies reflect that chronic disruption of circadian rhythms provides a
plinth for the occurrence and progression of multiple diseases across our lifespan.
Increasing epidemiological and experimental evidence are confirming that circadian
clocks are compromised in cancer. Altered expression of circadian clock components is
likely to be associated with the onset and progression of cancer. The concept of
targeting circadian clocks at the molecular level is rapidly evolving and opening a new
therapeutic window in cancer. Here we discuss the approaches and recent
advancements that have been made for the identification and development of clockmodulating small molecules bearing drug-like properties for the therapeutics and
therapeutic management of cancer. It is envisaged that this chapter will augment the
concepts of precision medicine in general and circadian-related system anomalies.
Ethnomycology and richness of macrofungi in rural communities of the southern region of Piauí, Brazil
Authors: Santina Barbosa Sousa , De Holanda Cavalcanti Andrade Laise , Farias Melo de Barros Roseli , Batista Lopes João
Published: June 2024

Background and Aims: Fungi play an important role in ecosystems and in human culture. In the Northeast region of Brazil, little is known about the importance of these organisms in rural communities. The objective of this study was to register the richness of macrofungi and how this richness is perceived in rural communities of Piauí, Brazil.Methods: A total of 176 inhabitants (99 women and 77 men) from the municipalities of Canto do Buriti and Guaribas were interviewed. Semi-structured interviews were used, complemented with an inventory of macrofungi. Samples were collected in eight areas of the two municipalities between December 2016 and February 2018, and the identifications were confirmed by specialists from the Federal University of Pernambuco and the Federal University of Paraíba. The Margalef Richness Index and the PCORD software were used for the analysis of the quantitative data; the qualitative analysis was based on the description of observational records and structured interviews.Key results: Fifty-one species of macrofungi (Basidiomycota and Ascomycota) distributed in six orders, 17 families and 32 genera were identified. Species richness (S=10.4) was considered high in the studied area. Agaricaceae was the most diverse family (18), followed by Polyporaceae (12). Macrofungi are perceived as environmentally important, but with little direct relevance to humans. According to the perception of local populations, some Agaricaceae species represent a risk to health. However, they are also seen as bioindicators for predicting climate change. Pycnoporus sanguineus (Polyporaceae), a species useful for local medicine, was the most cited, while Hexagonia hydnoides (Polyporaceae), Phellinus sp. and Fomitiporia sp. (Hymenochaetaceae) were perceived as parasites of timber plant species.Conclusions: The mycobiota present in the studied municipalities can be considered rich in macrofungal species and the local peoples recognize their presence, especially the presence of Agaricaceae and Polyporaceae.
Pengembangan prototipe sistem monitoring kualitas air tanah karst
Authors: Budiyanto Eko , Purnomo Nugroho Hari , Kurniawati Aida , Muzayanah Muzayanah
Published: June 2024

Air tanah karst merupakan satu sumber pemenuhan kebutuhan air utama bagi penduduk di wilayah karst. Kualitas air tanah karst dapat berubah secara dinamis dalam waktu yang cepat. Oleh karena itu, diperlukan satu sistem yang dapat memberikan informasi tentang kualitas air ini secara mudah bagi penduduk. Penelitian ini bertujuan membangun prototipe sistem monitoring kualitas air tanah karst. Metode eksperimen digunakan dalam penelitian ini. Sistem yang dihasilkan terdiri dari perangkat sensor (pH, kekeruhan, dan temperatur), mikrokontroler, sistem basis data pada server, dan sistem antar muka. Hasil pengujian menunjukkan prototipe sistem monitoring kualitas air ini dapat beroperasi dengan baik dan dapat memberikan informasi kualitas air dengan cepat bagi penduduk. Beberapa hal teknis perlu diperhatikan agar perolehan data kualitas air dapat berjalan lancar dan terhindar dari kerusakan peralatan.
Analisis Temporal Perubahan Garis Pantai Kedung Celeng Kabupaten Malang Tahun 1995-2021 Menggunakan Metode MNDWI (Modified Normalized Difference Water Index)
Authors: Abrar Ghairandi Al , Maghandi Mohammad Rendra , Hasbulloh Muhammad Hanif , Cholidah Nina Nila Ziyana , Masithoh Ferryati
Published: June 2024

Garis Pantai akan mengalami perubahan karena berbagai faktor, penelitian ini dilakukan di Pantai Kefung Celeng Kabupaten Malang dengan tujuan untuk untuk mengetahui perubahan garis pantai di Pantai Kedung Celeng  dalam kurun waktu 30 tahun terakhir, serta untuk mengatahui faktor serta dampak yang terjadi akibat perubahan garis pantai di Pantai Kedung Celeng. Data yang digunakan pada peneltian ini adalah data primer dan skunder, data primer diperoleh degan melakukan survei lapangan secara terstris dan data skunder diperoleh dari citra satelit Landsat pada tahun 1995, 2005, 2015, dan 2021. Pengolahan citra dilakukan dengan menggunakan metode MNDWI (Modified Normalized Difference Water Index). Perhitungan MNDWI akan menghasilkan tiga hasil yaitu nilai positif air lebih besar daripada di NDWI karena menyerap lebih banyak cahaya SWIR daripada cahaya NIR. Hasil dari penelitian ini adalah Sekitar tahun 2000 hingga 2005 proses perubahan angin, arus laut kearah timur, membuahkan abrasi tebing bagian barat dan pengikisan karang pantai yang membuahkan garis pantainya berubah, bagian barat lebih menjorok dan bagian timur terdapat sedimentasi pasir, pada tahun 2015 telah mengalami banyak perubahan karena berbagai fenomena alam yang terjadi terus menerus, dan pada tahun 2021 garis pantai tidak terlalu jauh bebeda dari tahun 2015, namun terjadi sedimentasi pada bagian tengah pantai sehingga membuahkan kawasan pantai ini cenderung mengalami periubahan pada bagian tengah saja.
Pemetaan Zonasi Kerawanan Bencana Gerakan Massa Tanah di Kabupaten Puncak, Provinsi Papua
Authors: Prabawa Bayu Argadyanto , Febriarta Erik , Ardiyanto Ridwan , Rosaji Fredi Satya Candra
Published: June 2024

The geographical and geomorphological conditions of Puncak Regency has a probability of experiencing the disaster, and based on news, it was found that the mass movements had occurred in Puncak Regency and claimed lives. This research aims to map the mass movement susceptibility zonation in Puncak Regency and analyze the factors that influence it. Method used in this research is a statistical model Frequency Ratio using several variables such as slope, aspect, rock type, lineament density, distance from geological structures, soil texture, distance from rivers, and distance from roads. The model results validated using the Area Under Curve value. The results shows that Puncak Regency dominated by the non-susceptible to moderately susceptible  in the northern part, while the Puncak Jaya mountains has a high-very high susceptibility class. The most influential variables on the occurrence of mass movement are rock type, lineament density, and slope. The validation results show that the results of the mass movement susceptibility model is statistically acceptable.
ANALISIS SATUAN KEMAMPUAN LAHAN UNTUK EVALUASI PARIWISATADI KAWASAN RAWAN BENCANA KAPANEWON CANGKRINGAN
Authors: Pulungan Widya Annisa Fitri , Permatasari Afrinia Lisditya
Published: June 2024

Implementation of spatial planning in an area is planned based on the physical condition of the environment. Kapanewon Cangkringan has tourism potential to be developed as a disaster mitigation-based tourism area which is used as a tourist center as well as education. Along with the rapid pace of development and the increasing number of tourists due to tourism activities, threats to natural resources and ecosystems are also increasing, so it is necessary to analyze land capability in Kapanewon Cangkringan. The methods used in this research are spatial data analysis (overlay), scoring and qualitative descriptive analysis. The purpose of this study is to determine the level of land capability and to determine the level of land capability and to determine the relationship between land capability and evaluation of tourism in disaster-prone areas in Kapanewon Cangkringan. The results obtained were Kapanewon Cangkringan divided into four land capability classes namely Low, Medium, Moderately High and Very High Development Capability classes with the most dominant development capability class being the Very High Development Capability Class. The link between land capability and evaluation of tourism in disaster-prone areas is that four out of fifteen tourist objects were identified as not in accordance with the level of land capability that had been analyzed. This is because, some of these tourist sites are in areas with low levels of development that should not be developed as tourism areas.
Distribusi spasial nitrat air tanah di Kecamatan Nanggulan, Kulon Progo, Yogyakarta
Authors: Falah Fajrul , Sejati Sadewa Purba
Published: June 2024

Residential areas in Nanggulan sub-district are mainly adjacent to irrigated rice fields. Groundwater in settlements close to irrigated rice fields has the potential to be contaminated with nitrates. Studies on the spatial distribution of groundwater nitrate around irrigated rice fields have never been conducted in Nanggulan District, Kulon Progo Regency. The study was conducted to determine the spatial distribution of nitrates in groundwater in Nanggulan District, Kulon Progo Regency. Nitrate data were collected through groundwater sample testing. The location of groundwater samples is determined using a systematic random sampling. The data was analyzed by spatial interpolation method through Arc GIS 10.6 software. The results showed variations in the spatial distribution of nitrates in the study area. Most of the study area had nitrate levels of 5-10 mg / L distributed in the south. Nitrates exceeding ten mg/L were distributed in the northern part of the study area. Based on research that has been conducted, it is known that 41% of groundwater in the study area is contaminated with nitrates, while 59% of groundwater is not contaminated with nitrates. Spatially, nitrate-contaminated groundwater is found in parts of Tanjungharo Village, some Wijimulyo Village, some Donomulyo Village, some Jatisarono Village, and some Kembang Villages. Groundwater not contaminated with nitrates is found in Banyuroto Village and most areas of Donomulyo Village. Factors that cause nitrate-contaminated groundwater are the location of excavated wells close to intensively fertilized irrigated rice fields, groundwater contained in geological formations of young Merapi volcano deposits, and groundwater depth of less than 5 meters.
Merajut Masa Depan Pariwisata Indonesia Ditengah Ancaman Krisis Global
Authors: Hastuti Hastuti
Published: June 2024

Pariwisata telah berkembang menjadi industri yang semakin berdampak besar pada masyarakat luas, bahkan seluruh bangsa, karena hubungannya dengan masyarakat, ekonomi, dan kearifan kolektif. Sebelum epidemi COVID-19, perjalanan dan pariwisata memainkan peran penting dalam perekonomian banyak negara. Meski terjadi lonjakan pekerja migran di luar negeri yang tidak terduga, sektor pariwisata memang memberikan kontribusi besar terhadap produksi barang-barang kebutuhan pokok (PDB). Pariwisata menjadi semakin tidak stabil sebagai akibat dari krisis keuangan dan energi global yang terkait dengannya. Fakta bahwa keterpurukan pariwisata tidak akan pernah bisa dicegah sepenuhnya merupakan indikasi betapa banyak warga masyarakat yang mendukung gaya hidup tersebut.
Cardiac Health Assessment Using a Wearable Device Before and After Transcatheter Aortic Valve Implantation: Prospective Study
Authors: Eerdekens Rob , Zelis Jo , ter Horst Herman , Crooijmans Caia , van 't Veer Marcel , Keulards Danielle , Kelm Marcus , Archer Gareth , Kuehne Titus , Brueren Guus , Wijnbergen Inge , Johnson Nils , Tonino Pim
Published: June 2024

Background

Due to aging of the population, the prevalence of aortic valve stenosis will increase drastically in upcoming years. Consequently, transcatheter aortic valve implantation (TAVI) procedures will also expand worldwide. Optimal selection of patients who benefit with improved symptoms and prognoses is key, since TAVI is not without its risks. Currently, we are not able to adequately predict functional outcomes after TAVI. Quality of life measurement tools and traditional functional assessment tests do not always agree and can depend on factors unrelated to heart disease. Activity tracking using wearable devices might provide a more comprehensive assessment.

Objective

This study aimed to identify objective parameters (eg, change in heart rate) associated with improvement after TAVI for severe aortic stenosis from a wearable device.

Methods

In total, 100 patients undergoing routine TAVI wore a Philips Health Watch device for 1 week before and after the procedure. Watch data were analyzed offline—before TAVI for 97 patients and after TAVI for 75 patients.

Results

Parameters such as the total number of steps and activity time did not change, in contrast to improvements in the 6-minute walking test (6MWT) and physical limitation domain of the transformed WHOQOL-BREF questionnaire.

Conclusions

These findings, in an older TAVI population, show that watch-based parameters, such as the number of steps, do not change after TAVI, unlike traditional 6MWT and QoL assessments. Basic wearable device parameters might be less appropriate for measuring treatment effects from TAVI.
Examining and Comparing the Energy Expenditure of Two Modes of a Virtual Reality Fitness Game (Supernatural): Indirect Calorimetry Study
Authors: Craig Tabitha V , Rhodes Ryan E , Sui Wuyou
Published: June 2024

Background

The effectiveness of virtual reality (VR) fitness games as a form of moderate to vigorous physical activity has yet to be thoroughly quantified through gold standard energy expenditure measures.

Objective

The purpose of this study was to examine the energy expenditure of 2 medium-intensity modes (“Flow and “Boxing”) of a VR fitness game, Supernatural, using indirect calorimetry.

Methods

Indirect calorimetry was used to examine relative and objective maximal oxygen consumption (VO2 max), metabolic equivalents of task (METs), and calories burned during medium-intensity bouts of both Flow and Boxing gameplay modes in young (mean age 25.42, SD 3.25 years), active individuals (n=12 female and n=11 male). METs and calories were also compared using a triaxial waist-worn accelerometer, an Apple smartwatch, and a VR headset. Mood states were assessed pre- and postbout using the shortened Profile of Mood States Questionnaire. Paired 2-tailed t tests were used to examine differences in game modes, between sexes, and pre-post exercise sessions.

Results

Objective and relative VO2 max averaged 1.93 (SD 0.44) L/min and 27.61 (SD 5.60) mL/kg/min, respectively, between modes. Flow (mean 8.2, SD 1.54 METs) and Boxing (mean 7.6, SD 1.66 METs) are both classified as high energy expenditure, vigorous activities. Calorie expenditure data of the accelerometer and VR headset differed significantly from the metabolic cart. Mood changes pre- to post exercise were consistent with expected values for moderate- to vigorous-intensity physical activity, with participants reporting that they felt more “active,” “full of pep,” “vigorous,” and “lively” (P<.05) following bouts. Male individuals reported higher objective oxygen consumption (VO2) for both Flow and Boxing modes; no other sex-specific differences were observed.

Conclusions

Both Flow and Boxing gameplay modes of Supernatural classify as vigorous physical activity and demonstrate the potential to promote mental and physical health benefits. Supernatural may be an effective exercise modality in a VO2 training program.
Exploring the Intersection of Schizophrenia, Machine Learning, and Genomics: Scoping Review (Preprint)
Authors: Hudon Alexandre , Beaudoin Mélissa , Phraxayavong Kingsada , Potvin Stéphane , Dumais Alexandre
Published: June 2024

BACKGROUND

An increasing body of literature highlights the integration of machine learning with genomic data in psychiatry, particularly for complex mental health disorders such as schizophrenia. These advanced techniques offer promising potential for uncovering various facets of these disorders. A comprehensive review of the current applications of machine learning in conjunction with genomic data within this context can significantly enhance our understanding of the current state of research and its future directions.

OBJECTIVE

This study aims to conduct a systematic scoping review of the use of machine learning algorithms with genomic data in the field of schizophrenia.

METHODS

To conduct a systematic scoping review, a search was performed in the electronic databases MEDLINE, Web of Science, PsycNet (PsycINFO), and Google Scholar from 2013 to 2024. Studies at the intersection of schizophrenia, genomic data, and machine learning were evaluated.

RESULTS

The literature search identified 2437 eligible articles after removing duplicates. Following abstract screening, 143 full-text articles were assessed, and 121 were subsequently excluded. Therefore, 21 studies were thoroughly assessed. Various machine learning algorithms were used in the identified studies, with support vector machines being the most common. The studies notably used genomic data to predict schizophrenia, identify schizophrenia features, discover drugs, classify schizophrenia amongst other mental health disorders, and predict the quality of life of patients.

CONCLUSIONS

Several high-quality studies were identified. Yet, the application of machine learning with genomic data in the context of schizophrenia remains limited. Future research is essential to further evaluate the portability of these models and to explore their potential clinical applications.
Improving the Performance of Transparent Conducting Electrodes Based on Cu Nanowires
Authors: Mardiansyah Dedi , Usna Sri Rahayu Alfitri , Nafisah Suratun , Harsojo Harsojo , Hatika Rindi Genesa
Published: June 2024

The fabrication of transparent conducting electrodes (TCEs) is dominated by indium tin oxide (ITO). Some efforts are being made to find alternative materials as a substitute for ITO. Cu nanowire (CuNWs) is an equivalent candidate as a replacement for ITO but has a weakness that is easily oxidized. In this contribution, we report an increase in the performance of CuNWs, which can reduce the effect of oxidation. In this study, we provide a coating of CuNWs using PVP, PVA, and silver nanoparticles (AgNPs). The morphology, formation structure, and conductivity of CuNWs have been investigated by scanning electron microscope (SEM), X-ray diffraction (XRD), and IV meter. The average length and diameter of the CuNWs were 5.5 μm and 120 nm, respectively. The transparent conducting has a stable conductivity after coating with PVP, PVA and AgNPs. The application of transparent conducting electrodes are sensors, electronic devices, solar cells, and organic light-emitting diodes (OLEDs).
Synthesis of Mesoporous Silica from Palm Oil Boiler Ash (MS-POBA) with Addition of Methyl Ester Sulfonate as a Template for Free Fatty Acid Adsorption from Crude Palm Oil (CPO)
Authors: Sitohang Cita , Kuncaka Agus , Suratman Adhitasari
Published: June 2024

The synthesis of mesoporous material by utilizing palm oil boiler ash (POBA) waste as the silica source and methyl ester sulfonate (MES) surfactant as the template for a high-porosity was investigated for free fatty acids (FFA) adsorption. The research was initiated with silica extraction from POBA by sodium hydroxide addition through the sol-gel precipitation method. Silica modification was carried out with MES surfactant and 3-aminopropyltrimethoxysilane (APTMS) as the co-structure-directing agent (CSDA) in different calcination temperatures. Mesoporous silica-POBA (MS-POBA) free template had a surface area, pore diameter, and pore volume (41.033 m2/g, 4.180 nm, and 0.250 cm3/g) lower than MS-POBA with the template (71.0147 m2/g, 7.923 nm, and 0.524 cm3/g). The ability of MS-POBA to adsorb FFA reached its optimum conditions with an adsorption time of 20 min and an adsorbent dosage of 0.24 g. The FFA removal by MS-POBA with the template was found to have higher adsorption ability, which was 35.54%, compared to the MS-POBA free template of 26.68%. The high porosity of MS-POBA with a template makes the FFA adsorption capacity of this material higher than MS-POBA free template.
Validation of An Efficient 2D-HPLC Method for The Determination of Pentazocine
Authors: Ahmed Maha Thamer
Published: June 2024

Pentazocine is an opioid analgesic used to treat moderate to severe pains. The real analysis for the pharmaceutical products containing pentazocine is basically to ensure the correct dose and patient safety. This study developed and validated an improved high-performance liquid chromatography (HPLC) method in the selective and accurate quantification of pentazocine. Two-dimensional (2D) HPLC technique is employed to enhance the resolution and selectivity compared to conventional HPLC methods. The 2D-HPLC instrumentation consists of two C18 columns coupling with a switching valve to capture fractions from the first column, which is analyzed in the second column. The mobile phase was optimized to 45% acetonitrile and 55% water with 0.1% phosphoric acid. The method was validated in the International Conference on Harmonization guidelines and shows excellent linearity (R2=0.998), limit of detection of 1.58 μg/L, accuracy of 97.70–102.50%, and precision by relative standard deviation (RSD) of 1.02–4.20%. Selectivity was verified in resolving pentazocine from paracetamol, caffeine, ibuprofen, and oxycodone in laboratory mixtures. The utility of the 2D-HPLC method was demonstrated by accurate quantification of pentazocine in pharmaceutical injections and tablets unaffected in excipients. This research provides a rich validating technique to enhance the quality control testing of pharmaceuticals containing pentazocine.
SDS-Assisted Hydrothermal Growth and Photocatalytic Activity of Like-Caviar MoFe2O4 Nanoparticle Decorated with Al2O3
Authors: Hameed Mohammed Ali , Ahmed Luma Majeed
Published: June 2024

Like-caviar molybdenum ferrite nanoparticles (MoFe2O4 NPs) have been successfully synthesized via a hydrothermal route in the presence of the negative surfactant (sodium dodecyl sulfate (SDS)). SDS acts as a template, stabilizer, and stops the aggregating process through storage. The mean crystal size of MoFe2O4 NPs rises with decorating it with Al2O3. Based on SEM analysis, the shapes of MoFe2O4, Al2O3, and their composite demonstrated like-caviar, like-brain cells, and like-grains, respectively. Al2O3 has been chosen to incorporate with spinel MoFe2O4 to make it color more light, this crucial step is necessary to enhance their optical characteristics. FTIR spectra observed the MoFe2O4 NPs are inverse spinel. The photo-decolorization test employs indigo carmine (IC) as a model pollutant. The quantum yields (Φ) of IC dye decolorization with studied photocatalysts are low, which may be created by quencher materials, dimerization of dye molecules, and photophysical deactivation processes (ISC process). Moreover, the photocatalytic activity of using MoFe2O4 raised after being decorated with alumina, which revealed an increase in the surface acidity, hydroxyl group adsorption, size, band gap, pHpzc of MoFe2O4 from 2.9–3.6 to 4.2–5.9 after decorated alumina. This pH is suitable for decolorizing IC dye, which has a pH of solution equal to 5.3.
Synthesis, Characterization, and Control Release of Zinc Layered Nitrate Intercalated with Beta-Napthoxyacetic Acid (BNOA) Nanocomposite
Authors: Abd Rahim Hasnatul Fitriah , Jalil Mohammad Nor , Sarijo Siti Halimah , Buyong Faeiza , Zaki Hamizah Mohd
Published: June 2024

In this research, the synthesis of the host using zinc nitrate-hexahydrate as a precursor to form zinc layered nitrate (ZLN) and the guest anion which is beta-napthoxyacetic acid (BNOA) will be intercalated with the ZLN to produce nanocomposites called ZLN/beta-napthoxyacetic acid (ZLNB). The method used for the synthesis of the host was self-assembly and ion exchange. The nanocomposites were confirmed with the basal spacing increases from 9.8 to 28.2 Å by using powder X-ray diffraction (PXRD). Therefore, proved the bigger basal spacing compared to the layered double hydroxide of MgAl and ZnAl. The appearance of the FTIR shift band at 1603 cm−1 of C=C aromatic ring indicates that the anions have been successfully incorporated into the interlayers of ZLNB. Moreover, the loading percentage estimated by the carbon content from the ZLNB determined by CHNS analyzer was 41.8% (w/w). The morphology analysis confirmed the plate-like structure for ZLN into flaky-like with irregular, porous and unambiguous structure for ZLNB by field emission scanning electron microscopy (FESEM). The controlled release property showed that the release of BNOA in the various aqueous solutions is in the order of Na3PO4 > Na2SO4 > NaCl and fitted into pseudo-second-order kinetic models.
Antibacterial Activity and CO2 Capture by Cerium-Copper Mixed Oxides Prepared Using a Co-precipitation Method
Authors: Kamonwannasit Sirilak , Futalan Cybelle Morales , Khemthong Pongtanawat , Youngjan Saran , Phatai Piaw
Published: June 2024

Indoor air pollution is comprised of fine particles, bacteria, fungi, and hydrocarbons. Acceptable indoor air quality is maintained using several layers of air filters. Alternative materials with the capacity to remove CO2 from indoor air with antibacterial efficacy need to be further investigated. Mixed oxides of Ce1.0-xCuxO (x = 0.0, 0.1, 0.5, 0.9, 1.0) were synthesized using a co-precipitation method. Characterization studies revealed that single oxides of Ce1.0O and Cu1.0O were of cubic fluorite and monoclinic crystal structures, respectively. Results also show that Ce0.1Cu0.9O and Ce0.5Cu0.5O were composites. All samples were classified as mesoporous materials with a type IV isotherm, and the main functional group was identified as Ce–O–Cu. The surface area of Ce0.5Cu0.5O was 17.63 m2/g. The highest CO2 adsorption capacity was 5.72 cm3/g for Ce0.5Cu0.5O. Moreover, the greatest antibacterial activity against B. subtilis (12.22 mm inhibition zone) and P. aeruginosa (7.34 mm inhibition zone) was observed for Ce0.5Cu0.5O at a 30 mg/L concentration. The synthesis of mixed Ce1.0-xCuxO oxides along with their satisfactory antibacterial performance and CO2 adsorption capacity, indicate its potential use as an alternative material for inclusion in indoor air filters.
Exploring the Anticancer Activity of Gold Complex with Newly Ligand (DDIBM): Synthesis, Spectral Identification and Magnetic Susceptibility of Its Metallic Complexes
Authors: Noor Siham Sami , Kareem Ibtihal Kadhim
Published: June 2024

The new heterocyclic ligand, 5-(dimethylamino)-2-(((2-((E)-(4,5-diphenyl-1H-imidazol-2-yl)diazenyl)benzyl)imino)methyl)phenol (DDIBM), was synthesized via the condensation of p-aminobenzylamine with 4,5-diphenyl imidazole, and the resultant compound was condensed with 4-(dimethylamino)-2-hydroxybenzaldehyde. Various instrumental techniques such as mass, 1H-NMR, IR, C.H.N elemental analysis, and UV-vis spectroscopy were used to analyze a newly synthesized ligand. A novel series of complexes was prepared by complexing the ligand with Ni(II), Cu(II), Co(II), and Au(III) and characterized using some of the mentioned techniques. Flame atomic absorption spectroscopy was used to measure the metal ion percentages in the complexes. The magnetic susceptibility and molar conductivity were studied. The electronic spectral data and the magnetic measurement predict the octahedral structure of the complexes except Au(III) complex which has square planer geometry. All complexes showed electrolyte properties. This study aimed to conduct an in vitro cytotoxicity comparative study of DDIBM and its Au(III) complex on human breast cancer cells (MCF-7) and other normal cells. The Au(III) complex was found to be highly selective in targeting cancer cells without affecting normal healthy cells, compared to the ligand. Thus, this complex can be considered as a new drug for treating breast cancer cells (MCF-7), and an attempt in the future to study its effect on other types of cancer.
Penilaian Visual Lanskap Objek Daya Tarik Wisata Alam dengan Menggunakan Metode ADO-ODTWA di Obyek Wisata Curug Muncar
Authors: Rahayu Kinanthi , Winastuti Dwi Atmanto
Published: June 2024

Artikel ini bertujuan untuk melakukan penilaian potensi visual lanskap obyek wisata alam di Curug Muncar. Penilaian dilakukan dengan menggunakan Metode Analisis Daerah Operasi Objek dan Daya Tarik Wisata Alam (ADO-ODTWA). Metode ini berfokus pada kualitas keindahan (pemandangan) atau kualitas visual lanskapnya agar mengetahui potensi yang dapat dikembangkan dan memperbaiki kekurangan dari obyek wisata alam Curug Muncar. Aspek-aspek yang dilakukan penilaian pada potensi visual lanskap Curug Muncar meliputi keindahan alam, keunikan sumber daya alam, potensi sumber daya alam yang menonjol, keutuhan sumber daya alam, pemanfaatan sumber daya alam, jenis kegiatan wisata alam, kebersihan udara dan lokasi, serta kerawanan kawasan. Berdasarkan hasil penilaian potensi visual lanskap diperoleh skor 920 yang termasuk dalam kategori cukup atau sedang untuk dikembangkan sebagai wisata alam dengan tingkat kelayakan sebesar 64%. Dari penilaian, diperoleh juga saran untuk pengelolaan yakni dengan mengembangkan jenis wisata alam lain di Curug Muncar seperti camping, birdwatching, sarana pendidikan alam dan olahraga ekstrem paralayang.
Optimalisasi Sanggar Among Lare dalam Rangka Peningkatan Taraf Hidup Masyarakat di Kalurahan Sendangsari, Kapanewon Pengasih, Kabupaten Kulon Progo, Daerah Istimewa Yogyakarta
Authors: Prasojo Prihantono  , Anggi Rahajeng
Published: June 2024

Pariwisata merupakan sektor yang berpengaruh terhadap peningkatan pendapatan di suatu daerah, termasuk kawasan perdesaan. Seiring dengan adanya Alokasi Dana Desa (ADD) dan banyaknya potensi yang dimiliki, pemerintah desa berlomba-lomba untuk mewujudkan wilayahnya menjadi desa wisata, salah satunya Kalurahan/Desa Sendangsari, Pengasih, Kulon Progo. Program ini juga didorong oleh Pemerintah Daerah Istimewa Yogyakarta (DIY) melalui kebijakan yang bernama Desa Mandiri Budaya. Penelitian ini bertujuan untuk menganalisis Sanggar Among Lare yang berada di desa tersebut dan menyusun strategi untuk mengoptimalkan keberadaannya sebagai wisata edukasi. Tulisan ini merupakan hasil observasi partisipatif dan wawancara dari kegiatan pemberdayaan masyarakat Kuliah Kerja Nyata (KKN) yang telah dilaksanakan. Strategi optimalisasi yang dilakukan oleh Tim KKN-PPM UGM YO-107 terdiri dari dua cara, yakni pengembangan sumber daya manusia melalui kegiatan pelatihan dan perumusan kebijakan berupa rekomendasi kebijakan bagi pihak terkait. Dengan mengoptimalkan potensi yang dimiliki, keberadaan Sanggar Among Lare diharapkan dapat memberikan dampak terhadap peningkatan taraf hidup masyarakat di Kalurahan Sendangsari.
Effect of Charging Current Variation on Internal Resistance in Lithium-Ion Batteries
Authors: Udiatma Keshawa , Andromeda Trias , Setiawan Dr. Iwan
Published: June 2024

Internal resistance of a battery is affected by the amount of charging current and how many charge cycles are carried out. The value of internal resistance is also related to the State of Health (SoH) of the battery. The smaller value of internal resistance indicates a higher SoH of the battery. This paper presents a comparison of internal resistance due to variation of charging current. The current values are 500 mA, 1000 mA, and 3000 mA. Lithium-ion 18650 batteries which have capacity 1200 mAh are charged by these current values. Three batteries are used using three scenarios, namely the 500 mA for scenario 1 using the Liitokala-Lii500 charger, 1000 mA for scenario 2 using the Liitokala-Lii500 charger, and the 3000 mA for scenario 3 using the XL4016 constant current (CC) constant voltage (CV) charger. Every battery is charged 20 times. Internal resistance of each battery is measured using YAOREA YR1030 module during experimental work. The data experiments indicate that variation of current of 500 mA for scenario 1, internal resistance is increased by 1 mΩ. Scenario 2, 1000 mA, internal resistance will extend by 1.4 mΩ. Scenario 3 which uses 3000 mA, gives the highest internal resistance alteration by 2.1 mΩ. It can be concluded that the greater values of charging current will affect a higher value of internal resistance.
Cultivar pueblos y ciudades en la Tierra Caliente de Michoacán, 1947-1961
Authors: Pérez Ortiz Luis Alejandro
Published: June 2024

El presente artículo aborda la historia de la planificación de la Tierra Caliente, donde a mediados del siglo xx se desarrolló una importante experiencia de fundación y reforma de centros de población, en el marco de un proyecto de desarrollo hidroagrícola. Para ello se da cuenta del contexto institucional y espacial, empleando cartografía histórica para mostrar sus alcances. El presente artículo aporta a un tema poco tratado como lo es el trasplante y tropicalización de las ideas de la planeación moderna, como el modelo de ciudad jardín en las llamadas ciudades agrícolas del país que, en conjunto con otras intervenciones, transformaron en dos décadas este lugar.
Tecnologías de asepsia espacial: política y control de la vida a inicios del s. xx en Costa Rica
Authors: Pérez Saborío Edgar
Published: June 2024

Este artículo transdisciplinario comprende las etapas que atravesó la asepsia para consolidarse como una tecnología biopolítica en la arquitectura y el urbanismo moderno en Costa Rica. Para esto, se repasan las infraestructuras y políticas vinculadas al Dr. Carlos Durán Cartín en la transición al siglo xx y hasta mediados de ese siglo. Se concluye que hubo una deriva endémica de la arquitectura moderna, en la cual la asepsia fue una pieza clave para la consolidación de un proyecto “civilizatorio” promovido por las élites del país; esta tecnología fue en sus inicios implementada para la gestión de microorganismos, hasta servir a la organización de alteridades biológicas humanas.
Modelo de solución conceptual en el proyecto arquitectónico
Authors: Reyes Peña Samuel , Mayorga Cervantes Juan Raymundo
Published: June 2024

Se presenta la prueba de un modelo de solución conceptual en el proyecto arquitectónico (mscpa) basado en sistemas complejos como alternativa de sistematización para la etapa de conceptualización, y como herramienta metodológica para apoyar los procesos creativos de estudiantes de arquitectura. Para definir el proceso creativo en esta disciplina se tiene que establecer el contexto de la creatividad y comprender la influencia de un marco conceptual en la misma creatividad del arquitecto. Como investigación aplicada, se plantea un experimento de campo con estudiantes de arquitectura en una práctica de solución conceptual, cuyos resultados evidencian la utilidad del mscpa como un fondo contextual.
Políticas públicas y globalización en el Centro Histórico de Mérida, Yucatán
Authors: Lara Jiménez José Jorge , Román Kalisch Manuel Arturo
Published: June 2024

La imagen urbana y usos actuales del Centro Histórico de Mérida son resultado de políticas públicas, principalmente, de las cuatro décadas recientes. En este trabajo se expone el origen e incidencia de tales políticas, para ello, se analizan dos grandes periodos de su historia, el primero, desde su fundación hasta el siglo xix, y segundo, del siglo xx a la actualidad, periodicidad vinculada a la establecida por la normativa federal. También se expone el papel de los diferentes actores en la gestión y ejecución de las políticas públicas, y se caracteriza el centro histórico como resultado de las políticas implementadas y la globalización.