bluuebunny/crossref_metadata_2025 huggingface dataset:
Manifestation of heterosis of signs of productivity in hybrids (F3 and F5) of lucern of seeding under conditions of high soil acidity
Authors: Buhayov V. D. , Horenskyy V. M. , Mamalyga V. S.
Published: November 2022

Aim. Assessment of the level of productivity, heterosis and the nature of inheritance in hybrids (F3 and F5) of alfalfa under conditions of high soil acidity (pH 5.2-5.3). Methods. Field, laboratory. Results. The results of research (2013-2020) on the level of productivity and effects of heterosis, the nature of inheritance of traits of fodder and seed productivity in 37 hybrid populations (F3 and F5), created with samples of alfalfa sowing and variable of different ecological and geographical origin, naturally soil background with high acidity (pH 5.2-5.3). Conclusions. Hybrid pop-ulations of alfalfa with a combination of high fodder and seed productivity against the background of soil acidity have been selected and proposed for use in the selection process: Regina / Zhidrune, Sinyukha / Mega, Sinyukha / Yaroslav-na, Grilys / Mega, Grilys / Regina. Samples Mega / Regina, Vika / Regina, Zhidrune / Regina, Zhidrune / Sinyukha, Mega / Grilys, Grilys / Vika Yaroslavna / Vika, Yaroslavna / Zhidrune, Grilys / Zhidrune, Vika can be used separately in selection process after further researches on forage productivity and seed – Regina / Mega.
Winter wheat productivity formation under water deficit in soil
Authors: Zhuk O. I. , Stasik O. O.
Published: November 2022

Aim. The aim of research was to investigate influence of water deficit in soil on morphology and productivity of bread winter wheat plants (Triticum aestivum L.). Methods. Wheat plants cultivars Podolyanka and Natalka were grown under optimal conditions until the earing-flowering phase, after that the experimental plants were transferred to drought regime for 8 days. The optimal supply of water was restored to the end of vegetation. The leaf surface area, the mass of internodes and ear were measured during the experiment. Ripened plants were analyzed by the yield structure. Results. It is established that the effect of water deficit in the critical earing-flowering phase of ontogenesis caused decreasing in the leaf surface area, mass of internodes and ear, weight of 1000 grains in both Podolyanka and Natalka cultivars. However, number of grains decreased only in cultivar Podolyanka under drought. Conclusions. Water deficit in the soil in the critical earing-flowering phase led to inhibition of growth processes and productivity reduction in bread winter wheat.
Evaluation of physiological, biochemical and yield indicators of wheat and maize genotypes exposed to sodium chloride
Authors: Khanishova M. A. , Tagieva K. R. , Azizov I. V.
Published: November 2022

Aim. Study the effect of sodium chloride on the physiological and biochemical characteristics of wheat and maize genotypes, to identify varieties tolerant to salinity. To create new salt-tolerant varieties of wheat and maize, a comparative analysis of the physiological and biochemical parameters of the parental and hybrid plants was carried out. Methods. Physiological parameters such as chlorophyll content, relative water content, and PSII activity have been studied in parental forms and hybrids. Results. When studying salt-tolerance of hybrids and parental forms, differences were detected in the relative amounts of chlorophyll (a+b), carotenoids, RWC, as well as the photochemical activity of chloroplasts. The effect of salt on the amount of chlorophyll a, chlorophyll b, and carotenoids, which are the main physiological indicators, is manifested in different ways in both hybrids and parental forms. Conclusions. Based on the physiological indices determined during the grain filling stage, the highest tolerance was manifested by the parental forms, Garabagh, Gobustan, and the hybrids, ♀Garabagh×♂Gobustan, ♀Garabagh×♂Mirbashir, ♀Garabagh×♂Sharg. Under the action of salt in all genotypes of corn found a slight increase in the content of soluble sugars. The highest sugar content was observed in the hybrid Zagatala 68 x Gurur.
Morphofunctional changes in some internal organs during domestication of pigs
Authors: Khokhlov A. M. , Fediaieva A. S. , Honcharova I. I. , Shevchenko O. B.
Published: November 2022

Aim. To identify the phylogenetic changes of the evolutionary process in the historical aspect of pig domestication. Domestication is the process of phylogenetic transformation of wild animals into domestic animals. The main role in this process belongs to artificial selection, especially its destabilizing form. Undoubtedly, as a result of destabilizing form of selection, wide phenotypic variation appears in domesticated pig populations. Methods. Using archaeological, morphological, biochemical, genetic and zootechnical methods of investigation, we were able to establish morphological features of some internal organs in connection with domestication of pigs. Results. In studying pig evolution, the European Wild Boar (Sus scrofa ferus) was the direct object of our studies in comparison with breeding animals of the Large White Pig Breed, which emerged after domestication of the Wild Boar in Europe. Modern research shows that artificial (destructive, disruptive, stabilizing) selection and selection under appropriate feeding and housing conditions played a significant role in domestication and breeding, namely the Large White Boar. Conclusions. Prematurity processes and formation of modern pig breeds mainly occurred by increasing the variability of traits, precocity, mass and size of animals, some internal organs and systems.
Effect of β-estradiol on the expression of human MGMT gene in cells in vitro
Authors: Nidoieva Z. M. , Lukash L. L. , Yatsyshyna A. P.
Published: November 2022

To determine whether the steroid hormone β-estradiol affects the transcription of the human MGMT gene. The expression status of the DNA repair enzyme O (6)-methylguanine-DNA methyltransferase (MGMT) is important when planning the treatment of patients with oncology, because its presence in tumor cells may reduce the effectiveness of alkylating chemotherapy. Alkylating chemotherapy is combined with hormone therapy in the treatment of tumors, so the study of the effect of β-estradiol on the number of transcripts of the human MGMT gene in cells in vitro has not only theoretical and also practical significance. Methods. We used a variety of methods, including culture, molecular genetic and biochemical, such as RNA isolation, cDNA synthesis, reverse transcriptase PCR, agarose and polyacrylamide gel electrophoresis, and statistical processing of the results. Results. We found a tendency of β-estradiol to downregulate the MGMT gene at mRNA level in both HEp-2 and 293 cells in a range of concentrations, except concentrations 1 and 5 nmol/L of β-estradiol in 293 cells. Conclusions. Our data support the hypothesis that β-estradiol is one of the hormonal regulators of the MGMT gene.
Utility of the trnH–psbA region for DNA barcoding of Aconitum anthora L. and related taxa
Authors: Tynkevich Y. O. , Biliay D. V. , Volkov R. A.
Published: November 2022

Aim. The genus Aconitum is represented in the Carpathian region by a significant number of endemic species. Some of these species, in particular A. pseudanthora and A. jacquinii, are included in the Red List of Ukraine. However, their taxonomic status and consequently the importance of conserving their natural resources remain uncertain. DNA barcoding techniques, e.g., the application of molecular markers based on variable regions of the chloroplast genome can help clarify these questions. Methods. DNA isolation, PCR amplification, sequencing of PCR products, phylogenetic analysis. Results. The psbA-trnH intergenic spacer region of A. pseudanthora and A. jacquinii specimens from Western Ukraine was amplified and sequenced. It is shown that the spacer sequences for these two species are identical, but differ in short indels and nucleotide substitutions from the psbA-trnH sequences of A. anthora s.l. specimens from Western Europe and China. Phylogenetic analyzes showed the phylogenetic affinity of the members of the A. anthora complex to the subgenus Lycoctonum. Conclusions. The use of the psbA-trnH intergenic spacer region for DNA barcoding makes it possible to unambiguously distinguish samples of A. jacquinii and A. pseudanthora from western Ukraine from samples of A. anthora s.l. of other geographical origins. The results obtained confirm the reticular nature of the evolution in the genus Aconitum.
Constraining the size and density composition of the Martian core by using second-order potential coefficient and recent precession rate of gravity field model
Authors: Zhong Zhen , Wen Qi-Lin , Liang Jin-Fu ,   School of Physics and Electronic Science, Guizhou Normal University, Guiyang 550025, China
Published: November 2022

It is still difficult to detect the existence of Martian solid inner core merely based on Mars seismic InSight data. To deal with this problem, our study intends to use the mean density and mean moment of inertia factor to constrain the size and density of Martian solid inner core. Using the Mars high-degree gravity field models: JGMRO120f and GMM3-120, and considering the recent precession rate, we obtain the mean density and mean moment of inertia factor, which are treated as the observed values. Referring to the 4-layers internal structure model of Mars, and considering the 4 parameters, i.e. crustal density, mantle density, density of outer core, size and density of inner core, we calculate the modeled values of the Martian mean density and the mean moment of inertia factor. From the minimum residuals between observed and modeled values of mean density as well as that of mean moment of inertia factor, it is found that the two gravity field models have the same result of distribution of free parameters. As to the optimized values of the free parameters, the two gravity field models even have the same results. Furthermore, the optimized crustal density, mantel density and density of outer core approach other studies, indicating the dependence of our results. Finally, our result demonstrates that Mars likely has a solid inner core with a size close to 840 km, and the density of inner core is nearly 6950 kg⋅m–3. Our result implies that Mars has an inner core not fully composed of pure iron, which is consistent with the recent study that Mars requires a substantial complement of light elements in Martian core. However, it is further needed to constrain the size and composition of Martian inner core due to the non-uniqueness of inversion results. With the improvement of processing technology on the InSight data, it can be further constrained for the size and composition of Martian inner core.
Experimental investigation of multiple-particle pattern based on one-dimensional grating resonance field
Authors: Qi Shao-Fu , Cai Fei-Yan , Tian Zhen , Huang Xian-Yu , Zhou Juan , Wang Jin-Ping , Li Wen-Cheng , Zheng Hai-Rong , Deng Ke ,   College of Information Science and Eengineering, Jishou University, Jishou 416000, China,   College of Physics and Mechanical and Electrical Engineering, Jishou University, Jishou 416000, China,   Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China,   College of Medical, Hunan University of Medicine, Huaihua 418000, China,   Suining County First Middle School, Shaoyang 422699, China
Published: November 2022

Manipulation of particles by ultrasonic waves is a primary technique in the fields of precision manufacturing, materials engineering, and in vitro diagnosis, since it can control the motion of objects in the sound field in a contactless and noninvasive manner. In general, the free sound field, such as the focused field and the plane wave generated by a single transducer can only manipulate a single particle. While the complex field generated by a transducer array should be actuated by a complex electric control system, which makes the manipulation device expensive and cumbersome. Thus, modulated acoustic field for particle manipulation is still needed. Here, we experimental realize a one-dimensional acoustic grating to tune sound fields for the parallel pattern of multiple particles. The physical mechanism is that due to the resonance coupling between the periodic diffraction wave on the surface of the acoustic grating and the Fabry-Perot resonant sound field in the acoustic grating slit, a periodical gradient sound field on the surface of the acoustic grating is induced. Then, particles in the periodical gradient sound field can be trapped in two stable positions in one period of the grating. These concepts and realizations of particle patterns in the acoustic grating pave the way for implementing the parallel manipulation of particles in acoustic manipulation technologies.
Advancing DEI in research publishing – putting strategy into practice
Authors: Sule Sam , Dunne Maeve
Published: November 2022

In September 2021, Springer Nature made a formal commitment to Diversity, Equity & Inclusion (DEI) across our external Research & Solutions activities. Since then, our journals, books and magazines are elevating issues of diversity, representation, equity, justice and much more in both their content and their processes. From launching the industry’s first guide to content that may be harmful to human population groups, a new approach to ethics dumping and helicopter research, a transgender name change policy and Nature’s first ever guest edition on racism in science: we’ve taken steps to integrate DEI into the way we work and the content we create. This poster will talk about our experience so far turning strategy into practice, and the projects we’re planning for the near future from language guides to data collection.
Enriching preprints to attain reproducible open science
Authors: Pepe Alberto
Published: November 2022

In order for science to be truly open, readers and reviewers must be able to understand how authors produced the computational results, which parameters were used for the analysis, and how manipulations to these parameters affect the results. Increasingly, journals and funding agencies are mandating that researchers share their code and data when reporting on computational results. However, even when data and code are provided by authors, and published, they are oftentimes just posted as links and relegated to platforms entirely separated from publishing workflows, disconnected from the published “full text”. We believe that preprints are better suited than external repositories in enabling open, reproducible science because they are connected to the published full text via scholarly infrastructure, they are author-centric, and allow versioning. In particular, we propose a simple (yet innovative and experimental) workflow whereby authors deposit a preprint version of their articles in an html-first preprint server. In it, authors can then enhance the preprint, through edits and revisions, with data, code, computational notebooks, interactive visualizations, and dashboards. As such, preprints can be used as an experimental vehicle for directly disseminating the interactive, data-driven, and multi-media nature of Open Science outputs, in parallel and connected with more traditional published outputs.
Supporting equity, economies of scale, and interoperability by applying the International Data Space model to open science usage and impact reporting
Authors: Drummond Christina
Published: November 2022

The OA Book Usage Data Trust effort (www.oabookusage.org) is exploring how an International Data Space (IDS) could address issues of trust, data quality, and resource-burdens for OA usage data reporting and analytics. Currently individual libraries, publishers, and scholarly publishing platforms and services must normalize, curate, and aggregate their usage and impact metrics as provided from numerous platforms. While well-resourced organizations may have the time and expertise to curate and aggregate open and privileged usage data across provided COUNTER-compliant and non-COUNTER compliant reports; smaller presses, publishers, and innovative projects often lack the resources necessary to process incoming usage data and benefit from robust OA impact analytics.  
To address this disparity and improve the quality and interoperability of OA book usage data, OA book publishing stakeholders are exploring how to adopt the international data space (IDS) models and standards. Awarded 1.2Million USD by the Mellon Foundation, a team led by OPERAS, OpenAIRE, the University of North Texas, and Johns Hopkins University are hosting community consultations to determine what data stewardship and security practices are needed to achieve trusted direct usage data exchange at scale.
Open Science Policies seen from the perspective of researchers' communities
Authors: Manco Alejandra
Published: November 2022

During the last ten years, many institutions have begun to design, adopt, and implement open science policies (Schmidt et al., 2018; Kretser et al., 2019). Nevertheless, there is a research gap in tackling how these policies impact researchers' knowledge production. Therefore, this research investigates the researcher's opinions, perceptions, and experiences with open science policies concerning knowledge production processes from researchers from Brazil, France and Peru. It aims to highlight differences and similarities in the science disciplines across these countries. Furthermore, it aims to provide an overview of how communities of researchers from the sciences – physics, chemistry, and biology – visualize open science policies, meaning their opinion and discourse on this subject and whether their knowledge production processes have changed and to what extent they had an impact on their research products.
Interlinked and integrated research support services
Authors: Ikonen Arto
Published: November 2022

This poster introduces the efficient set of research support services available in University of Jyväskylä’s (JYU) Open Science Centre (OSC). The set includes several essential services for researchers to help them execute an open and responsible research process. 
The continuous improvement of research support services has led to an interlinked, integrated and harmonious set of technical solutions, processes and workflows which meet the needs of researchers and help them implement open science and FAIR policies in practice. They also save time and enable better working processes for the researchers but also for the experts conducting these services. 
The poster describes two main services which are interlinked and which both aim to make processes and workflows effortless. 
One of the main services is when metadata from research information system Converis is utilized using API in the self-archiving process of research articles to the institutional repository. OSC’s experts record the publication metadata on behalf of researchers and the same metadata of the publications is used in the self-archiving process. 
Also, data harvesting is used to get notification of new publications of researchers affiliated to JYU. Often the researchers don’t even have to inform OSC when their new publication is out. This effortless process combines two different systems (CRIS and institutional repository) and connects workflows regarding them. 
The poster also introduces a dynamic research data management tool which enables a fluent data management process. The goal of the development of this tool has been to free the researchers of having to learn the use of several different systems. The tool helps the researchers to track the handling process of their data and guides through all the necessary phases of the data management process. Again, the data once recorded is being utilized in other systems and in other phases of the whole process. Both the tool and the data management process it enables are integrated to other systems which are needed for example in storing and sharing the research data.
Rebuilding our community networks post-COVID-19
Authors: Brady Kyle , Knowles Kirsty
Published: November 2022

Background. Communities of Practice (CoP) have long been discussed for their abilities to support individuals in decision making, knowledge sharing, and collegiate support[1]. Individuals who are actively involved in CoP can also act as agents for change within an institution[2]. The University of St Andrews Open Access team have developed strong links to School administrators and established ‘deposit hubs’ in Schools whereby researchers can get local support from the ‘hubbers' for creating new research output records in the University’s Current Research Information System (CRIS), as well as support for uploading open access versions and input based on specialist local knowledge such as linking research grants.
Aims. To assess the impact of COVID-19 on the CRIS activity of our ‘hubbers’, to determine whether more could be done to improve resilience in the face of time-constraining factors. We also sought to determine what measures might be taken to improve communication channel within the University and how a network might develop and grow.
Methods. A quantitative assessment of the impact of COVID on the CRIS activity of hubbers and administrators whom we have developed links with. Through qualitative assessment and dialogue with administrators we wanted to ascertain other issues that result in delays or non-deposit.
Results. There was a correlation between the uptick in CRIS record creation and manuscript deposit activity by the Open Access team, and a decrease in activity by ‘hubbers'. Feedback received also suggested there was inertia due to common queries arising, and further inactivity due to inadequacies with communication channels. It was also clear that the uptick in administrative effort from the OA team needed to be addressed.
Conclusion. Determining a correlative effect of a discrete set of administrative tasks based on quantitative indicators is prone to error. However, the Open Access team is confident that such Communities of Practice do add value to research culture, both in quantitative measurable results, and in terms of qualitative cultural effects. But more is needed to be done to enhance resilience, transparency, and confidence. It was decided therefore that a frictionless communication channel was required using Microsoft Teams, to bring together ‘hubbers’ and limit wasted effort by sharing best practice, a set of resources, and guides to ensure common standards and consistency, as well as an FAQ section.
Neutrosophic-principal Component Analysis of Causes of Performance Gap among Private and Public School Students in the Basic Education Certificate Examination
Authors: Eunice Osei-Asibey , Eric Wiah Neebo , Nortey Ezekiel N. N.
Published: November 2022

The decade - old academic achievement discrepancies at the basic school level that are widely emphasized are still being worked on heavily in current research. In this study, we present a novel Neutrosophic-Principal Component Analysis and Two-way Neutrosophic ANOVA to analysing the causes of Performance Gap among private and public school students in the Basic Education Certificate Examination. One-hundred and eighty-nine respondents from the Ada East and West Districts of Ghana were involved in the study. We present a modified Neutrosophic regression equivalence of the classical least squares to solve problems of indeterminacy. The results showed that of the total 87% variability, three main components—student characteristics, instructor characteristics, and administrative-logistic features—accounted for 36%, 31%, and 20%, respectively. The remaining 13% of the variability, which was attributed to random effects by the Neutrosophic PCA technique, was tested using a two-way Neutrosophic ANOVA where the results identified that interaction between the identified factors was a contributing factor that needed to be explained. Our results reveal that Neutrosophic-PCA is a potential method to lessen human response errors, which are frequently tainted with ambiguous, conflicting, imprecise, indeterminate or uncertainty. When there is just a slight difference between the two options, the forced selection caused by the traditional Likert method will be eliminated by our new approach. When studying respondents' opinions, we recommend researchers to employ Neutrosophic- PCA in order to minimize any bias that may result from the responses' lack of precision.
Further Review of Aspirin in the Treatment of Kawasaki Disease
Authors: Shi Zhaoling , Hsieh Kai-Sheng , Wang Hong , Yang Xiaodong , Zhang Ling , Kong Xiangyue , Feng Jianying , Wang Juyan , Jiao Fuyong
Published: November 2022

Aspirin only prevents platelets from accumulating in the dilated coronary arteries and prevents thrombosis, thus minimizing thrombosis as much as possible, and does not shrink the already dilated coronary artery tumor. Therefore, it plays an important role in the treatment of Kawasaki disease, but it is not the cause of treatment. Aspirin is common in the treatment of Kawasaki disease in children, and its effect is to reduce acute inflammatory response and alleviate platelet aggregation. Aspirin has been used to treat Kawasaki disease for more than 50 years. Since 1961, when Kawasaki discovered the first reported case of hemorrhagic shock caused by aspirin in children with Kawasaki disease, we need to re-explores the use of aspirin in the treatment of Kawasaki disease.
A Study to Refix the Critical Limit of Copper in the Major Rice Growing Soils of Tamil Nadu, India
Authors: Ravindran Angelin Silviya , Chakrapani Kanimozhi , Ravindran Susan Poonguzhali
Published: November 2022

Aims: To refix the critical limit of Cu in the soils of the major rice-growing tracts of Tamil Nadu.

Study Design:  Completely Randomized Design and Randomized Block Design.

Place and Duration of Study: Department of Soil Science and Agricultural Chemistry, Tamil Nadu Agricultural University between 2015 to 2018.

Methodology: The pot culture study was conducted in the laboratory followed by the field trials in the selected farmers'plot itself. The soil and plant samples are analyzed for soil copper and the data were statistically analyzed by following the standard procedures.

Results: The Cu deficient soils showed a significant response to the application of graded levels of Cu. For obtaining higher rice production in severely Cu-deficient soils (L1 to L9: 0.33 to 0.95 mg      kg-1), the Cu fertilizers may be applied @ 1.50 kg ha-1 i.e. 6.0 kg CuSO4  ha-1 (+ NPK) while in moderately Cu deficient soils (L10 to L13: 1.28 mg kg-1), the Cu level @ 1.00 kg ha-1 i.e. 4.0 kg CuSO4   ha-1 (+ NPK) increased significantly the grain and straw yields and in soils having high initial Cu status (L14, L15: 1.91, 2.12 mg kg-1), the Cu level @ 0.50 kg ha-1 i.e. 2.0 kg CuSO4 ha-1 (+ NPK) showed a significant increase in grain and straw yields.

Conclusion: The present investigation was carried out with the objective of re-fixing the critical limit in wetland soils and accordingly the critical limit for DTPA - Cu in wetland soils and rice crops at the panicle initiation stage was re-fixed as 0.93 and 4.82 mg kg-1, respectively. Based on this, it is possible that a graded dose of micronutrient fertilizers (Cu) may be prescribed to rice crops for the major rice-growing soils.
A Study on Challenges and Suggestions of Farmers to Promote Agro Tourism Centres in Karnataka State in India
Authors: Vishwanath H. , Suresha S. V. , Manjuprakash . , Savitha C. M.
Published: November 2022

Agriculture in India is facing acute problems from production till marketing of the produce. Hence, it is needed to supplement the income of rural folk and the Indian farmers should find an alternate means of livelihood and agro tourism is one such approach. It also has the capacity to generate a marginal or supplementary source of income and also creates employment opportunities to the farmers. The study was conducted in four selected districts viz., Bangalore, Chikmagalur, Hassan, and Madikeri districts of Karnataka state. In total 120 farmers were interviewed personally with an objective to understand the challenges the farmers face in promotion of ATC and also sought their suggestions to overcome the challenges. Expost facto design was used for the study. The study revealed that, high cost of labour (83.33%) was the major financial challenge it is due to fact that the most of the labourers were from outside their locality that comes in the search of job and demand more than the localities. Lack of mindset for commercial approach (83.33%) and weak communication skills of the farmers (75.00%) were human resource challenges this is due to the reason that organised efforts are seems to be lacking in this. insufficient literature for agro tourism practice (87.50%) was a major technical challenge, less tourists during peak agricultural activities (80.00%) and Lack of governmental support (89.16%) were the situational and policy challenges faced by the farmers respectively, The probable reason for the above mentioned challenges might be that, since, the concept has emerged in the recent past, the proper research works have not been undertaken the policy recommendations have not been put forth before the government. Complete tourism package should be provided to encourage ATC (79.16%), ministry of tourism should support and promote ATC (75.83%) and provide sales and marketing support (75.00%) were few of the suggestions given by the farmers to overcome the challenges. The government need to come up with the price policy mechanism with respect to tour packages in order to prevent loss to farmers. If ATCs are promoted and widely adopted, it will provide supplementary income to the farmers and helps in generating the employment at the rural ecosystem.
Effect of Integrated Nutrient Management on Growth Parameters, Yield Components and Yield of Wheat (Triticum aestivum L.) under Central Plain Zone of Uttar Pradesh
Authors: Verma Himani , Pathak R. K. , Kumar Anil , Sachan Ravindra , Pandey Hanuman Prasad , Tiwari Abhishek , Yadav Abhishek Singh
Published: November 2022

Field experiments were conducted to studies effect of integrated nutrient management on growth parameters, yield components and yield of wheat during rabi season of 2020-21 and 2021-22 at students instructional farm, Chandra Shekhar Azad University of Agriculture & Technology, Kanpur. The experiment consist of 10 treatments combinations in randomized block design with three replications consisted of different combination of inorganic fertilizer, organic manure and biofertilizer. Wheat variety HD-2967 was grown with the recommended agronomic practices. On the basis of results emanated from investigation it can be concluded that among the growth parameters maximum plant height at maturity was 109.25 cm and 110.12, maximum number of effective tillers is 352.67 and 355.72 and maximum spike length is 13.55 cm and 13.79 cm are associated with the treatment T10 [100%NPK + FYM + S30+ Zn5 +Azotobacter + PSB] during the both years of experimentation. Similarly, among the yield components and productivity parameters maximum values in relation to number of spikelet ear-1, grain ear-1, 1000 grain wt. (gm), grain yield (q ha-1) and straw yield (q ha-1) were found in the treatment T10 [100%NPK+FYM+S30+Zn5+Azotobacter+ PSB].
Determining The Effect of Plant Growth Regulators on Growth, Yield and Quality of Guava (Psidium guajava L. Cv. Allahabad Safeda)
Authors: Lanusungit . , Prasad V. M. , Bahadur Vijay , Rana Shilpa
Published: November 2022

Aim: Guava (Psidium guajava L.) is a member of the family Myrtaceae and the order Myrtales which is 4th most important crop in India after mango, increasing productivity. Therefore, In addition to Plant growth regulator are required for proper growth, yield and quality of guava.

Study Design: The experiment comprised of 10 treatments of different levels of PGR replicated thrice in a Randomized Block Design. The main objective of the experiment was to find out the effect of different PGR on growth, quality as well as to evaluate the yield and yield attributes of guava. Three concentrations of gibberellic acid (GA3) at 100, 150 and 200 ppm, three concentrations of naphthalene acetic acid (NAA) at 50, 100, and 150 ppm, and three concentrations of Brassinosteriods at 200, 400, and 600 ppm.

Place and Duration of Study: So, to find out Effect of Plant Growth Regulators and Brassinosteroids on Growth, Yield and Quality of Guava (Psidium Guajava L. Cv. Allahabad Safeda") A field experiment was conducted at the Central Research Farm, Department of Horticulture, Naini Agricultural Institute, Sam Higginbottom University of Agriculture, Technology and Sciences (SHUATS), Prayagraj, during 2021- 22.

Results: Treatment T9, which consisted of the T9 (Naphthalene Acetic Acid (NAA) @150ppm) had the best effect on Plant  height (335.7 cm), number of flowers per plant (61.3), fruiting buds per plant (151.8), number of fruits per plant (48.23), fruit weight (137.7 g), Fruit length (5.36 cm), fruit diameter (7.33), weight of pulp/fruit (104.57 g), weight of seed/fruit (6.74 g), total soluble salts (TSS) (10.97○ Brix), vitamin C content (188.52 gm) ,total sugar (8.03), acidity (1.27 %) and yield (33.3 t/ha).

Conclusion: According to the present investigation it is concluded that treatment T9 T9 (Naphthalene Acetic Acid (NAA) @150 ppm) was found most effective in terms of growth, yield and quality of Guava (Psidium Guajava L. Cv. Allahabad Safeda").
Mapping of Routine Coronavirus Vaccination 2019 in Tshopo Province, DR Congo, July to December 2021
Authors: Mandefu Salomon Otowange , Emakanya Briston Mongita Esol’e , Kiangano Elysée Akuku , Tomilalo Fabrice Otolito , Mandefu Fortune Otowange , Tukutuku Michel Liketa , Kama Valentine Liata , Etisomba Flavien Mongita , Mosongolia Jacques Baitoasola
Published: November 2022

The new 2019 coronavirus (Covid-19), recently known as "SARS-CoV-2" by the International Committee on Virus Taxonomy, is a beta-coronavirus, homologous to the bat coronavirus and closely related to SARS-CoV. outside of medical care of Covid-19 symptoms, vaccination is one of the most effective means of providing lasting protection for humans.

This descriptive-cross-sectional study included 3 886 persons vaccinated in routine vaccination mode in the 2 sites: Makiso-Kisangani General Reference Hospital and the Kisangani fiftieth anniversary hospital in the Makiso-Kisangani Urban health area, from July to December 2021. It shows that men (59%) have adhered more than women (41%). People aged 18-54 were vaccinated (59%) more than those aged 55 and over (41%). 71 of those vaccinated (2%) had no co-morbidity.

An overall acceptance of 64.7% was observed, with a gradient of 77.8% among medical professionals, 52.2% among nurses and 37.2% among nursing assistants. 11.4% of vaccinated health professionals and 85% of vaccinated persons did not return for the second dose. The Kisangani fiftieth anniversary hospital site recorded a drop-out rate of 93%. Minor IPD (0.3%) was observed among those vaccinated. Moderna was the most preferred/used vaccine (46%) and the Makiso-Kisangani General Reference Hospital site was the most used/attended (66.5%). The wastage rate was 12% (all antigens combined) of which 2 antigens (Astra Zeneca & Moderna) stood out at 21% and 13% respectively > 10% (Standard).

The objective of this study is to present the mapping of vaccination in the province of Tshopo, DRC in the first half of the year (2021) of the introduction of vaccine against covid-19 in order to protect the population against this pandemic.
Clinical Characteristics and Treatment Outcomes of HIV+ and HIV- Tuberculosis Patients Followed and Treated at the Regional Hospital of Oyem, Northern Gabon: A Two-Year Retrospective Study
Authors: Obiang Cédric Sima , Mba Thiéry Ndong , Moundounga Hilaire Kenguele , Mezui Pelche Bertrand Owono , Pambo–Pambo Arnaud Brice , Ondo Joseph Privat , Engonga Louis-Clément Obame
Published: November 2022

Background: The objective of this study was to analyse the clinical characteristics of HIV+ and HIV- tuberculosis patients followed and  treated at the Oyem Regional Hospital Centre (ORHC).

Materials and Methods: During this study conducted between January 2019 and December 2021, data collection was based on the exploitation of medical records and registers of results from the medical analysis laboratory of the regional hospital of Oyem, in which there were personal data (gender and age) of the patients, the status of HIV infection, clinical characteristics (pulmonary or extra pulmonary TB), and finally, the therapeutic outcomes of the patients after anti-tuberculosis and antiretroviral treatment. Binomial test following the Normal distribution was used to find an association between the percentages of extrapulmonary TB and TB+/HIV+ co-infection.

Results: In this study, 128 confirmed TB cases were selected. While 54 (42.19%) were co-infected with TB+/HIV+, 74 patients (57.81%) were monoinfected with TB+/HIV+.  Among all these patients, 93 (72.66%) were reported to have extra pulmonary TB and 35 (27.34%) had pulmonary TB. A normal binomial test showed that TB+/HIV+ co-infection was significantly associated with extrapulmonary TB (p=0.04). Patients were put on anti-tuberculosis treatment according to the manufacturers' indications. Despite a total of 15 deaths (8.93%) in both mono- and co-infected patients, there was a favourable outcome, with 35 patients (27.34%) declared cured. With 8 deaths, mortality was higher in the co-infected than in the non-HIV infected TB patients who recorded 7 deaths.

Conclusion: By indicating a relatively high prevalence of HIV infection in TB patients, this study showed that TB+/HIV+ co-infection was associated with extra pulmonary TB, the severe form of the disease, and increased mortality in patients, hence the need to strengthen joint activities to control this co-infection.
Distinct p53 phosphorylation patterns in chronic lymphocytic leukemia patients are reflected in the activation of circumjacent pathways upon DNA damage
Authors: Mancikova Veronika , Pesova Michaela , Pavlova Sarka , Helma Robert , Zavacka Kristyna , Hejret Vaclav , Taus Petr , Hynst Jakub , Plevova Karla , Malcikova Jitka , Pospisilova Sarka
Published: November 2022

TP53 gene abnormalities represent the most important biomarker in chronic lymphocytic leukemia (CLL). Altered protein modifications could also influence p53 function, even in the wild‐type protein. We assessed the impact of p53 protein phosphorylations on p53 functions as an alternative inactivation mechanism. We studied p53 phospho‐profiles induced by DNA‐damaging agents (fludarabine, doxorubicin) in 71 TP53‐intact primary CLL samples. Doxorubicin induced two distinct phospho‐profiles: profile I (heavily phosphorylated) and profile II (hypophosphorylated). Profile II samples were less capable of activating p53 target genes upon doxorubicin exposure, resembling TP53‐mutant samples at the transcriptomic level, whereas standard p53 signaling was triggered in profile I. ATM locus defects were more common in profile II. The samples also differed in the basal activity of the hypoxia pathway: the highest level was detected in TP53‐mutant samples, followed by profile II and profile I. Our study suggests that wild‐type TP53 CLL cells with less phosphorylated p53 show TP53‐mutant‐like behavior after DNA damage. p53 hypophosphorylation and the related lower ability to respond to DNA damage are linked to ATM locus defects and the higher basal activity of the hypoxia pathway.
Nonlinear filtering‐based output tracking error constraint control for permanent magnet synchronous motors with complete unknown coefficients
Authors: Wang Jinying , Wang Yanping
Published: November 2022

This article investigates the problem of the output tracking error constraint performance for permanent magnet synchronous motors with complete unknown coefficients. First, to achieve the output tracking error constraint performance, an improved barrier Lyapunov function combined with exponent‐type performance is given. Then, to erase the effects of unknown coefficients, adaptive compensation strategy, fuzzy logic systems, and Nussbaum‐type function are utilized, which relax the assumption requirement that the partial coefficients must be known in the related results. Further, to simplify the control design, a novel nonlinear filters‐based dynamic surface control method is presented. Unlike the previous linear filters‐based ones, it can achieve better control performance. It is proved that by utilizing the proposed method, all the signals in the closed‐loop systems are bounded, and also the prescribed output tracking error constraint condition does not violate. Final, simulation example verify the effectiveness of our proposed method.
The Electronic Properties of a 2D Ruddlesden‐Popper Perovskite and its Energy Level Alignment with a 3D Perovskite Enable Interfacial Energy Transfer
Authors: Shin Dongguen , Zu Fengshuo , Nandayapa Edgar R. , Frohloff Lennart , Albert Emily , List‐Kratochvil Emil J. W. , Koch Norbert
Published: November 2022

The success of using 2D Ruddlesden‐Popper metal halide perovskites (MHPs) in optoelectronic devices has ignited great interest as means for energy level tuning at the interface with 3D MHPs. Inter alia, the application of 2D phenylethylammonium lead quaternary iodide (PEA2PbI4)/3D MHPs interfaces has improved various optoelectronic devices, where a staggered type‐II energy level alignment is often assumed. However, a type‐II heterojunction seems to contradict the enhanced photoluminescence observed for 2D PEA2PbI4/3D MHP interfaces, which raises fundamental questions about the electronic properties of such junctions. In this study, using direct and inverse photoelectron spectroscopy, it is revealed that a straddling type‐I energy level alignment is present at 2D PEA2PbI4/3D methylammonium lead triiodide (MAPbI3) interfaces, thus explaining that the photoluminescence enhancement of the 3D perovskite is induced by energy transfer from the 2D perovskite. These results provide a reliable fundamental understanding of the electronic properties at the investigated 2D/3D MHP interfaces and suggest careful (re)consideration of the electronic properties of other 2D/3D MHP heterostructures.
A Spacer Cation Assisted Nucleation and Growth Strategy Enables Efficient and High‐Luminance Quasi‐2D Perovskite LEDs
Authors: Kong Lingmei , Luo Yaning , Turyanska Lyudmila , Zhang Ting , Zhang Zhipeng , Xing Guichuan , Yang Yingguo , Zhang Chengxi , Yang Xuyong
Published: November 2022

Quasi‐2D Ruddlesden‐Popper perovskites receive tremendous attention for application in light‐emitting diodes (LEDs). However, the role of organic ammonium spacers on perovskite film has not been fully‐understood. Herein, a spacer cation assisted perovskite nucleation and growth strategy, where guanidinium (GA+) spacer is introduced into the perovskite precursor and at the interface between the hole transport layer (HTL) and the perovskite, to achieve dense and uniform perovskite films with enhanced optical and electrical performance is developed. A thin GABr interface pre‐formed on HTL provides more nucleation sites for perovskite crystal; while the added GA+ in perovskite reduces the crystallization rate due to strong hydrogen bonding interacts with intermediates, which promotes the growth of enhanced‐quality quasi‐2D perovskite films. The ionized ammonium group (NH3+) of GA+ also favors formation of polydisperse domain distribution, and amine or imine (NH2 or NH) group interact with perovskite defects through coordination bonding. The spacer cation assisted nucleation and growth strategy is advantageous for producing efficient and high‐luminance perovskite LEDs, with a peak external quantum efficiency of over 20% and a luminance up to 100 000 cd m−2. This work can inform and underpin future development of high‐performance perovskite LEDs with concurrent high efficiency and brightness.
Nanozyme‐Engineered Bioglass through Supercharged Interface for Enhanced Anti‐Infection and Fibroblast Regulation
Authors: Xu Ziqi , Wang Tianyi , Li Yixiao , Wen Mengyao , Liang Kangqiang , Ruan Chenlong , Zhang Lianbing , Xue Yumeng , Shang Li
Published: November 2022

Effective therapy of infection impaired tissue defects has long been an important but challenging topic, and alternative antibiotic‐free solutions are greatly demanded to tackle bacterial infections and promote tissue repair. Herein, the use of supercharged gold nanoclusters (AuNCs) with enhanced enzyme mimic activity as novel interface modulator of bioactive glass nanoparticles (BGN) for infected wound treatment is reported. The supercharged AuNCs exhibit extraordinary affinity toward BGN, leading to the robust immobilization of AuNCs on BGN (BGN‐AuNCs). Functional AuNCs endow BGN with superior peroxidase‐like activity for catalytic antibacterial action, which can kill bacteria with a concentration down to 75 µg mL−1 within 6 h due to the production of highly toxic ·OH. Moreover, expression level of COL‐1, TGF‐β, and FGF‐2 in fibroblasts is actively up‐regulated to 2.9, 3.1, and 1.6 times higher than that of control group due to the positive effect of BGN‐AuNCs on cell proliferation. Meanwhile, intrinsic photoluminescent property of AuNCs enables the direct visualization of BGN at both in vitro and in vivo levels for potentially bioimaging‐guided therapy. Further in vivo results demonstrate that BGN‐AuNCs hold enormous promise for infectious disease therapy and pro‐regeneration, and the proposed supercharged interface engineering strategy is attractive for developing advanced functional nanomedicines.
Self‐Amplified Competitive Coordination of MnO2‐Doped CeO2 Nanozyme for Synchronously Activated Combination Therapy
Authors: Chen Ying , Liu Yong , Guo Chunmei , Yin Chao , Xie Chen , Fan Quli
Published: November 2022

Tumor‐specific combination therapy has shown great promise in cancer theranostics. However, the therapeutic efficacy is usually suppressed because most of the therapeutic systems are not able to synchronously activate their different therapeutic approaches and the local concentration of tumor‐associated stimulus is generally insufficient to fully activate the combination therapy process. Herein, a MnO2‐doped CeO2 nanozyme‐based nanomedicine (Ce6@CMNRs) is reported for tumor‐specific synchronously activated chemodynamic/photodynamic combination therapy. The tumor‐overexpressed H2O2 substitutes the Ce6 on Ce6@CMNRs surfaces via competitive coordination and then decomposes into •OH under acidic condition, achieving the chemodynamic therapy (CDT). Meanwhile, the substituted Ce6 triggers photodynamic therapy (PDT) under laser irradiation that is suppressed before the substitution occurs. Thus, H2O2 can synchronously activate both CDT and PDT of Ce6@CMNRs with a similar level in tumor sites. Moreover, the activated PDT‐induced oxygen starvation further triggers the generation of H2O2 to continuously replace the residual Ce6 coordinated on the nanorod surface, thereby leading to the full activation of PDT and CDT. Also, the doped MnO2 enhances the generation of •OH and provides high contrast for magnetic resonance imaging (MRI) with the help of glutathione. Therefore, Ce6@CMNRs are promising candidates for MRI‐guided CDT/PDT combination therapy with minimized side effects and high efficiency.