bluuebunny/crossref_metadata_2025 huggingface dataset:
Tres eremitorios rupestres medievales en el valle del Duratón (Sacramenia y Canalejas de Peñafiel)
Authors: Repiso Cobo Salvador
Published: October 2024

El presente trabajo tiene por objeto el estudio de tres conjuntos eremíticos, de naturaleza rupestre, ubicados en el cuenca del río Duratón. Llevan por nombre San Juan Paniagua –en Sacramenia (Segovia)–, Nuestra Señora del Olmar y Piedramediana –en Canalejas de Peñafiel (Valladolid)–. Pertenecen a la Alta Edad Media, siglos X-XI, como se puede constatar por los restos arqueológicos que conservan: arcos ultra-semicirculares, de estilo “repoblación”, y tumbas excavadas en la roca. El estudio incluye un análisis individualizado de su emplazamiento y sus estructuras: celdas, enterramientos, ermitas de fábrica, elementos decorativos; sin olvidar la consiguiente interpretación. Todo ello inserto en el contexto histórico en el que se desenvuelven: repoblación del valle del Duero, en torno a los castros de Peñafiel y Sacramenia; de sus aldeas, iglesias y monasterios partían los eremitas para ocupar el yermo. De uno de ellos conocemos el nombre –Juan Paniagua–, sobre el resto lo desconocemos todo.
Estimation of the soil erosion and sediment trapping using Gerlach troughs in different Land Uses in Luangprabang Province
Authors:   Souphanouvong University, PHIHMALATH Soubanh
Published: October 2024

This study aims to study sediment loss in different areas by collecting data from the Reservoir and Gerlach troughs in the Luangprabang Province, Laos The implementation of this experiment was a selection of study areas to install soil sediment retention tools (Gerlach trough) according to 6 treatments such as T1: No teak+Ruzi grass; T2: No teak + Fallow; T3: Teak with low understory density + Natural regrowth; T4: Teak with low understory density + Ruzi grass; T5: Teak with high understory density+ Natural regrowth; T6: Teak with high understory density+ mixed fodder cover (Ruzi and Napier grass). In 3 replicates/treatments by RCBD design, a total of 18 instruments will be installed by installing them in a row on both sides of the soil, to trap the soil sediment that flows with the water, then there will be a collection of samples that can be collected, and then filter the soil sediment and dry it at a temperature of 105 degrees, for a period of 48 hours and calculate the amount of soil sediment loss in the area. Results found that the highest soil loss (sediment) was in the area planted teak with low understory density + Natural regrowth (T3) followed by the area planted teak with low understory density + Ruzi grass, (T4), and the lowest soil loss was in the area no teak+Ruzi grass (T1) and the area no teak + fallow (T2). While the highest surface water runoff was in the area planted teak with low understory density + Natural regrowth (T3) and the area planted teak with low understory density + Ruzi grass, (T4). On the other hand, factors that are related to surface water runoff and soil sediment loss such as percentage of land cover density, slope of the land, and residue or humus on the land were found that the area no teak with planted Ruzi grass and the area no teak with fallow (natural growth) had lowest rate of surface water runoff and lowest soil sediment loss compared to other areas. It can be concluded that the land cover factor has an important role in helping to reduce surface water runoff and help prevent soil sediments from being lost to runoff in agricultural land and upland cultivation.
Urban Green Infrastructures and Its Impacts on the Urban Environment: A Review
Authors: Miakhel Mohammad , Abdulrahimzai Amjad Ahmad , Habib Ahmadullah , Behsoodi Mohammad Mukhlis
Published: October 2024

Urban green infrastructure plays a crucial role in preserving a green urban environment, thus contributing significantly to human health. The absence of such infrastructure can lead to environmental challenges, particularly in the face of escalating global urbanization. Green urban infrastructure proves essential for maintaining cleanliness in urban areas, especially as major cities worldwide grapple with escalating air pollution exacerbated by the inadequate presence of green spaces, green roofs, green walls, and domestic and private gardens emerge as noteworthy contributors to mitigating these challenges. As the global population steadily increases, a collective effort is imperative to enhance green infrastructure and cultivate public awareness to address the pressing issue of air pollution in cities. Green spaces serve as a pivotal indicator of urban verdancy, offering a myriad of benefits, including environmental cleanliness, the creation of recreational spaces, the promotion of health and well-being, the facilitation of children’s mental development, the presentation of aesthetically pleasing urban landscapes, temperature reduction, and pollution mitigation. This comprehensive review analyzed 60-70 studies on urban green infrastructures and their impacts on the urban environment. A library research methodology was used, focusing on literature from Google Scholar published in the last two decades which delves into the multifaceted aspects of urban environmental cleanliness, providing valuable insights for policymakers, and urban planners with a profound understanding of their impacts. Stakeholders can proactively implement measures to enhance cleanliness in the urban environment.
AVALIAÇÃO DE PROGRAMAS DE FORMAÇÃO DE PROFESSORES: CRITÉRIOS E IMPACTOS
Authors: Paiva Eliana Guimarães Barros , Silva Eliane Costa Cardoso da , Silva Odelio Cardoso da , Silva Adrailton Oliveira , Santos Anaina Gabriela dos , Pinto Edimara Cristiane Ferreira , Rosada Joceline Ferreira do Nascimento , Guimarães Ueudison Alves
Published: October 2024

Considering the incessant and turbulent social changes that permeate today's society, teacher training stands out as a vital path for updating and improving the professionals responsible for teaching and educating. Thus, the objective of teacher training is not limited to the discourses and epistemological bases that support teacher preparation but expands to foster a deep reflection on educational practice and equip professionals with the essential skills to align the profile of the citizen we educate with emerging social demands. Therefore, it becomes imperative to evaluate the results of training programs and actions aimed at teachers, to uncover the consequences of these initiatives and, thus, verify the real effectiveness of training programs aimed at teachers. In this scenario, the importance of evaluating training programs explodes in relevance, revealing itself as a crucial element in the incessant search for educational quality. This document aims to highlight, in a vibrant way, the urgent need to evaluate evaluation levels, identify the appropriate moments for each evaluation modality, and determine the instruments for collecting information. The analysis of the agents involved in this evaluation process will be addressed with intensity, highlighting how these aspects interconnect to create a robust and impactful feedback cycle, aiming to reveal the magnitude of the importance of continuous evaluation in improving teacher training and adapting to constantly changing social dynamics.
DESENVOLVIMENTO DE POLÍTICAS EDUCACIONAIS E SEU IMPACTO NA FORMAÇÃO DE PROFESSORES E GESTÃO ESCOLAR
Authors: Garcia Cintinara , Santos Alexandre Ferreira dos , Barrozo Daniella Wilges de Oliveira , Woehl Janivia Glaci Scholze , Santos Leidiane Aparecida dos , Sousa Helena Leandro de , Vieira Vanessa Maria de Sá Souza , Guimarães Ueudison Alves
Published: October 2024

This study highlights that the development of educational policies plays a very important role in teacher training and school management. Therefore, through bibliographical research, the influence of these policies on pedagogical and administrative practice was explored. Thus, the analysis revealed that effective educational policies not only qualify and update teachers, but also guide school management towards a more participatory and efficient approach. The effectiveness of these policies is closely linked to their ability to adapt to local needs and involve all participants in the educational process. Thus, the literature review demonstrated that policies that consider the specificities of educational communities and encourage the active participation of teachers and managers have a significant positive impact on the quality of education and school management. Thus, the study confirms that the implementation of educational policies aligned with local realities and the needs of educators can promote substantial improvements in teacher training and the management of educational institutions.
EDUCAÇÃO EM DISCURSO: O PROCESSO AVALIATIVO NO ENSINO À DISTÂNCIA
Authors: Barbosa Julye Hemylle Martins , Silva Lidiane Ferreira da , Rezende Aline Costa Cavalcante de , Costa Luziane Lima da , Santos Elissandro Neves dos , Santos Leidiane Aparecida dos , Guimarães Ueudison Alves
Published: October 2024

This article aims to discuss the evaluation process in the Distance Education (EaD) modality. Therefore, it is noteworthy that the specific objectives include a brief explanation about educational assessment and understanding the importance of the assessment act in the teaching-learning process in distance learning. Methodologically, this is qualitative research, bibliographic in nature. In the considerations, the relevance of assessment as a pedagogical action in the educational context stands out. In distance learning, assessment takes on different configurations, due to the physical distance between educator and student. Thus, assessment in distance learning requires constant interaction between the subjects involved in the process, so that the training of individuals occurs in an integral manner. In this sense, the research reveals that assessment in distance learning requires adaptive methodologies and continuous interaction between participants, to ensure comprehensive and effective training for students. Therefore, the need to rethink traditional assessment practices and adopt innovative approaches that consider the specificities of distance learning stands out.
FORMAÇÃO DE PROFESSORES PARA A EDUCAÇÃO INFANTIL: NECESSIDADES E PERSPECTIVAS
Authors: Santos Anaina Gabriela dos , Pinto Edimara Cristiane Ferreira , Rosada Joceline Ferreira do Nascimento , Santos Elissandro Neves dos , Oliveira Simone Lopes de , Costa Luziane Lima da , Barbosa Armando Lima , Guimarães Ueudison Alves
Published: October 2024

This article addresses a disturbing issue regarding the training of professionals working in early childhood education, exploring in depth the constitution of the teacher, his/her reflective practice and teaching identity. Its purpose is to highlight the relevance of teacher training, emphasizing, through a detailed analysis of several authors, the importance of the identity construction of the education professional and of critical reflection in teaching training and practice. This is a literature review that seeks support from renowned scholars to illustrate the importance of continuous and in-depth training for these professionals. Thus, the focus is on the need to adequately prepare those who will be responsible for constructing the learning of children from zero to five years of age, an important and formative period in the lives of individuals. The review aims to emphasize how the training and identity of the teacher are essential not only for personal development, but also for pedagogical effectiveness and the quality of early childhood education.
O POTENCIAL DA INTELIGÊNCIA ARTIFICIAL NA APRENDIZAGEM EDUCATIVA
Authors: Oliveira Sandra Regina de
Published: October 2024

The use of artificial intelligence (AI) in education has emerged as a topic of growing importance as educational institutions seek to innovate and enhance their pedagogical practices. This study aims to explore how AI can reconfigure learning processes and transform traditional educational practices. In a context where personalized learning is vital, AI stands out as a powerful tool to meet the individual needs of students, promoting the development of essential 21st-century skills. The bibliometric analysis conducted reveals a significant increase in academic interest in the application of AI in education, especially in the last five years, indicating an awakening to technological possibilities. The main areas of investigation include personalized learning, intelligent tutoring systems, and educational data analysis, known as learning analytics, which allow real-time monitoring of student progress. AI offers immediate feedback, adapting to each student’s learning pace, improving academic performance, and reducing educational inequalities. However, for this transformation to occur effectively, it is crucial that educational institutions integrate these technological solutions into their pedagogical approaches. However, the research points to significant gaps, such as unequal access to AI technologies, limiting the democratization of benefits. The lack of infrastructure and specialized teacher training hinders effective implementation. Additionally, there is a shortage of studies focused on the development of socio-emotional skills. Therefore, research must advance in the search for new technologies, ensuring an equitable and enriching learning environment. The future of education, transformed by AI, promises to be a space where all students can thrive, developing skills to face the challenges of the 21st century.
HANSENÍASE EM MENORES DE 15 ANOS NO ACRE
Authors: Garcia Laís de Brito , Melo Jose Johnata Paiva de , Peninche Luciana Ribeiro da Silva , Leitão Francisco Naildo Cardoso , Gonçalves Franciely Gomes
Published: October 2024

Introdução: Hanseníase é uma doença crônica infecciosa, causada pelo Mycobacterium Leprae, que tem afinidade por células cutâneas e células nervosas, com riscos de comprometimento neurais e desenvolvimento de incapacidades físicas. Apesar de todo avanço em termos de tratamento, o Brasil ainda ocupa o segundo lugar no ranking em número de casos. O acometimento em menores de 15 anos, reflete sérios prejuízos no controle da doença. Objetivo:  Descrever os aspectos epidemiológicos e clínicos dos casos de hanseníase em menores de 15 anos notificados no estado do Acre, Brasil, no período de 2013 a 2023. Método: Trata se de um estudo descritivo, retrospectivo, transversal, realizado a partir de dados secundários coletados no Departamento de Informática do Sistema Único de Saúde – DATASUS, do Ministério da Saúde- MS, através do TABNET, utilizando dados do Sistema de Informação de Agravos de Notificação – Hanseníase, no período de 2013 a 2023. Resultados: Foram observados 89 casos de hanseníase em menores de 15 anos notificados no estado do Acre. Os municípios de Rio Branco, Cruzeiro do Sul e Tarauacá apresentaram maior número de casos da doença. Predomínio na classificação operacional multibacilar e formas clínicas dimorfa e virchowiana, grau zero no diagnóstico e não registro do grau na cura, respectivamente. Conclusão: O acometimento de hanseníase em menores de 15 anos demonstra potencial descontrole da doença, principalmente no tocante ao diagnóstico tardio, com formas clínicas avançadas da doença com grau de incapacidade física instalado, demonstrando a urgente necessidade de medidas de controle no local de estudo.
RUSSIA’S HYBRID WARFARE IN THE WESTERN BALKANS: GEOPOLITICAL STRATEGIES AND PROXY ACTORS
Authors: Kuçi Gurakuç
Published: October 2024

This paper examines Russia’s hybrid warfare tactics against the Western Balkans, focusing on using direct and indirect methods to exert influence in the region. The study delves into Russia’s strategic use of media manipulation, cyberattacks, and disinformation campaigns, alongside its employment of proxy state and non-state actors such as Serbia, Republika Srpska, and the Serbian Orthodox Church. Leveraging historical, cultural, and religious ties, Russia seeks to destabilize the Western Balkans and prevent closer integration with NATO and the European Union. Special attention is given to the geopolitics of elections, where Russia manipulates electoral processes in countries like Montenegro and North Macedonia to favour pro-Russian or anti-Western political forces. By analyzing key case studies, this paper explores how Russian hybrid warfare exploits regional vulnerabilities—such as ethnic divisions and weak political institutions—while employing tactics of soft power and military cooperation. The findings indicate that Russia’s hybrid warfare, including electoral manipulation, poses a significant threat to regional stability and international security, underscoring the need for strengthened Western engagement to counter Russian influence. This study offers critical insights into the evolving nature of hybrid warfare and its implications for the geopolitical landscape of Southeast Europe.
Teacher Perception: Secondary Level Skill Development Support for Students with Specific Learning Disabilities
Authors:   , Spect Philip
Published: October 2024

Defining the special education framework and teacher roles continue to be a challenge as schools face the differentiated needs of 21st-century learners. Delineating the functions and duties of special education teachers (SETs) at the secondary level provides a unique challenge, which is addressed by a midsized suburban high school developing the Inclusive Consultation Model (ICM). This innovative instructional model is school-wide and multi-disciplinary, impacting both special education and academic teachers. Through weekly consultation, the SET supports the content teacher in contributing instructional methods to meet the varied student needs in class. Outside of class, SETs justify the value of their professional support by teaching students with disabilities in a dedicated skill instructional room (SDR) as an integral part of the students’ IEP goals and skill interventions. The targeted instruction provided in the SDR encourages goals for education which allow for student differences. Through a series of qualitative surveys, open-ended questionnaires, and a focus group, teacher data was gathered to ascertain the effectiveness and challenges of meeting special needs at the secondary level using this focused instructional method. The obstacles, frustrations, achievements, and rewards revealed in SET perspectives guide pedagogy to further contribute to the academic knowledge of the role, and ultimately, the purpose of educators in providing student intervention. Future research could inform how an instructional model using trained teachers providing targeted intervention in separate settings could impact student engagement and academic performance.
Leading with Heart: The Importance of Emotional Intelligence for Effective 21st Century Leadership
Authors: Westover Jonathan
Published: October 2024

Abstract: This article examines the importance of emotional intelligence for effective 21st century leadership. It defines emotional intelligence as having four key components - self-awareness, self-management, social awareness, and relationship management - which allow leaders to connect with others, navigate social situations effectively, and make well-rounded decisions. A review of research finds strong correlations between higher emotional intelligence and stronger leadership abilities across industries, as emotionally intelligent leaders inspire higher employee engagement, make strategic choices considering both logic and emotions, and effectively develop talent through understanding others' perspectives. The article provides practical strategies for leaders to develop their emotional skills and illustrates real-world examples, arguing that focusing on emotional intelligence through self-reflection, active listening, role-playing, and soliciting regular feedback is crucial for leaders seeking to reach their full leadership potential and positively transform their organizations.
Microbiome and Human Health: Recent Insights and Future Directions
Authors:   Theodore Bilharz Research Institute, Fahmy Azza
Published: October 2024

The human microbiome comprises a complicated assembly of microorganisms inhabiting the body and its surfaces. It plays an important role in various physiological functions, such as digestion, immune homeostasis, and disease prevention. The development and improvement of sequencing technologies have advanced our knowledge of these microbial ecosystems and their interactions with host species. Probiotics, prebiotics, and fecal microbiota transplantation are the therapeutic methods in this regard that have been the focus of considerable research regarding their role as a means to alter the microbiome toward better health. Probiotics are preparations of live antibiotic-producing microbes, which favorably affect intestinal barrier integrity, alter the immunologic response of the host, and stimulate the growth of probiotic bacteria. Prebiotics are dietary nondigestible fibers, whose selective fermentation promotes the growth or activity of beneficial bacteria within the gastrointestinal tract, reducing the risk of disease by maintaining gut health. In spite of the fact that it is a very promising technique, with the exception of treatments for Clostridioides difficile infections, most require further studies before general use. The gut microbiome is also highly dependent on diet and lifestyle. Diets high in fiber enhance the abundance of symbiotic bacteria, whereas high-fat diets strongly reduce microbial diversity and increase proinflammatory bacterial species. In addition, regular exercise and sleep are critically important for coping with stressful conditions. Poor sleep and chronic stress degrade microbial communities, leading to dysbiosis. Apart from the potential of such research in microbiomes, other challenges include individual variability and ethical concerns; these are very important to note during translation to the clinic. Ongoing microbiome research holds tremendous promise for personalized health and prevention that deserves to be encouraged toward future treatments and human health.
Behavioral theories and models to enhance compliance in cardiac rehabilitation programs for acute myocardial infarction – A narrative review
Authors:   The University of Lahore, Lahore, Pakistan Correspondence to: usmanmalik_ucp@hotmail.com, Malik Usman
Published: October 2024

Acute myocardial infarction (AMI) is a serious and common illness that affects the cardiovascular system. Its sudden onset, high fatality rate, and recurrence rate significantly impact patients’ safety and quality of life. Owing to considerable improvement in living standards, AMI has become a major cause of death and disability, seriously increasing the burden on society. The cardiac rehabilitation program, which involves a multidisciplinary approach to assist patients with daily life guidance, diet guidance, exercise guidance, disease knowledge guidance, medication guidance, psychological guidance, risk factor control guidance, and other comprehensive guidance, has been proven to play a decisive role in the recovery of patients’ cardiac function and the improvement of their quality of life. In addition, these programs help reduce treatment costs and prevent the reoccurrence of disease as well as adverse effects in cardiac patients. However, the introduction and execution of these initiatives are currently in their early stages, characterized by a gradual pace and encountering numerous challenges. Specifically, in the context of AMI, there have been documented instances of reduced engagement, adherence, and compliance with rehabilitation programs, even within industrialized nations. Diverse treatment phases and models have been designed to enhance patient care, patient participation, compliance, and effectiveness of rehabilitation programs. Participation in post-myocardial infarction management CR programs has been reported under par levels which is posing a great threat and burden on society. Various theories and models of behavioral change are proposed to improve patient participation and compliance in cardiac rehabilitation. These theories and models have been utilized in the past to improve patient health and can also improve patients’ perception, and behavior toward active participation in cardiac rehabilitation programs.
RANCANG BANGUN MESIN PENGISI BOTOL OTOMATIS BERBASIS ARDUINO MEGA 2560 DENGAN INTERFACE NEXTION HMI
Authors: Listiana Reni Listiana , Yurika Yurika - , Rossi Fattaahku Muhammad
Published: October 2024

Indonesia is experiencing rapid development in the industrial sector, especially in the packaging and bottle filling industry. Research on microcontroller-based automatic bottle filling systems has also developed a lot. Reducing manufacturing costs and simplifying a working system is the goal of a process in industry, so it is necessary to design a prototype to maximize the charging system with the Arduino program without destroying accuracy in charging. With this prototype, the accuracy of the liquid volume, response time, and working system will be known so that in making this filling machine prototype, several stages are carried out including consultation, literature study, design, creation and testing of the system as well as analysis of the results obtained from testing the prototype. In this research, volume testing and total time testing for the entire system were carried out at an Arduino set point of 250 ml and an Arduino set point of 180 ml. The test process for filling 2 bottles in 1 process produces results, namely for a set point of 250 ml, it produces an average volume of 248 ml and an average total time of 57.195 seconds, while the test with a set point of 180 ml produces an average volume of 177 ml with the total average time is 47.638 seconds. So it can be stated that this prototype is capable of producing filling with relatively stable water volume results. The principle of this prototype system is simple, namely the system runs in a structured manner based on triggers from sensors and certain time intervals.
PENGARUH KONSENTRASI KALSIUM PROPIONAT DAN DEKSTRIN TERHADAP MUTU FISIKOKIMIA DAN ORGANOLEPTIK MINUMAN SERBUK SARI BUAH PEPAYA
Authors: Marlina Lusi , Kharisma Ratna Ayu
Published: October 2024

Papaya fruit (Carica papaya L.) is one of the tropical fruits that can be found everywhere, apart from the delicious taste of this fruit is also rich in complete nutrition with several vitamins contained in papaya fruit. Papaya fruit has a very high tendency to decay, which causes a relatively short shelf life. Therefore, efforts or techniques are needed to process fresh papaya fruit into functional food products with long shelf life. This study was conducted with the aim of determining the effect of the addition of calcium propionate and the amount of dextrin on papaya fruit pollen drinks. This study used an experimental method with a two-factor completely randomized design (RAL), namely the addition of calcium propionate (0.1%, 0.2%, 0.3%) and the addition of dextrin (5 g, 10 g, 15 g) with reference to SNI 01-4320-1996. The test parameters analyzed were water content, vitamin C content, antioxidants, organoleptic tests of color, aroma, taste and texture. The results showed that the addition of calcium propionate and dextrin significantly influenced the water content, vitamin C, antioxidant and organoleptic tests. The addition of calcium propionate concentration (0.1%) and the amount of dextrin (15 g) produced the best quality of papaya fruit pollen drink.
RANCANG BANGUN CNC PRINTER 3 DIMENSI MENGGUNAKAN ARDUINO MEGA 2560
Authors: Ramdani Rizki , Saleh Agus , Primahidin Indra
Published: October 2024

In making this 3 Dimensional CNC Printer machine, the design and construction process is divided into several main parts. The main parts include; design for the mechanical part, design for the frame part, design for the control and calibration system. In the mechanical section, the motor type is selected and the transmission system is designed. The type of motor used is the Stepper Motor Type 17210 G Shinano Kenshi with specifications; angular movement of 1.8 degrees/pulse with a current of 1 A, voltage of 2.6 VDC, resistance of 1.5 Ohm/phase, inductance of 2.8 mH/phase and holding torque of 0.3 Nm. For transmission, it uses a pulley and belt transmission type. The frame uses Tslot 2040, Vslot 2020 and Aluminum Composite materials for the engine mount. In the control and calibration section, this 3 Dimensional CNC Printer machine uses an Arduino Mega 2560. In mechanical testing, movement trials were carried out in the x, y and z axes. The test results show that the movement is as expected. For the x-axis movement, it is 60 mm, the y-axis is 80 mm and the z-axis is 100 mm.
Anxiety in Using Bangla as a Second Language: A Case of Indigenous Undergraduate Students of the University of Dhaka
Authors:   Lecturer (Adjunct), Department of Bengali Language, Institute of Modern Languages, University of Dhaka, Bangladesh, Humaiara Momy Sabiha Al
Published: October 2024

This study investigates the level and sources of anxiety experienced by indigenous undergraduate students studying at Dhaka University. It also aims to examine the variance between the sources of anxiety. For this purpose, 60 indigenous undergraduate students from different departments were purposively chosen to participate in this study. The research instrument used in this study was a modified version of Foreign Language Classroom Anxiety Scale (FLCAS) developed by Horwitz, Horwitz, & Cope (1986). Data were analyzed through descriptive statistics. The results obtained from this study revealed a moderate level of anxiety as reported by the students. The undergraduate students experienced different sources of language anxiety, such as communication apprehension, fear of negative evaluation, and test anxiety. Also, the significant difference between the means of communication apprehension and test anxiety was found. The results of this study suggest that the classroom atmosphere should be motivating and encouraging and the teachers are recommended to deal with anxiety-provoking situations carefully.
IMAM ZARKASYI DAN KONSEP PENDIDIKAN HIDDEN CURIKULUM
Authors: Echsanuddin Echsanuddin
Published: October 2024

Imam Zarkasyi (1910-1985) of Gontor Ponorogo East Java along with his two other brothers called Trimurti (the three founders of Pondok Modern Gontor), both KH. Ahmad Sahal (1901-1977) and KH. Zainuddin Fannani (1905- 1967) were the most dedicated figures on the modern Indonesian Islamic boarding schools education system. Kiai Zarkasyi was not only well known in Indonesia but even in the Muslim world. This article attempts to gain a deeper understanding about Zarkasyi‘s educational philosophy and his hidden curriculum; and how the patterns of its implementation in the educational system processes thus provides a significant influence on his discipliners, with a qualitative approach in the form of naturalistic phenomenology through literature study and empirical experience as a means of checking the validity of confirmatory data. The findings revealed that all educational activities in Pondok Modern Gontor has governed by a soul by design which maintained formal curriculum (intracurricular and extra-curricular) called written curriculum. On the top of all, the study discoveres the patterns of hidden curriculum applicable as the affect of edicational process under the formal curriculum. It took place in many models such as learning by instruction, learning by doing, and so on. Here, in fact, there is the strength and success of education in dormitories, such as in Pondok Modern Gontor which has a significant direct effect on the students, who in turn has an effect on the nation character building and the religion.
The northernmost ruins of the globe. Eigil Knuth's archaeological investigations in Peary Land and adjacent areas of High Arctic Greenland
Authors: Grønnow Bjarne , Jensen Jens Fog
Published: October 2024

An important part of the heritage of Count Eigil Knuth (1903-1996) is his archaeological archive including contextual information on prehistoric sites gathered during six decades of research in High Arctic Greenland. The finds and observations are a key to the understanding of human life under extreme conditions in a long-term perspective and represent a unique piece of evidence concerning the early cultural history of the Eastern Arctic.
Knuth’s expeditions from 1932 to 1995 took him to Greenland and Canada, in particular High Arctic Greenland. In a number of important articles Knuth published the findings dating back to the earliest human settlement in Greenland. However, he never  managed to present the complete body of information and results from his many investigations. The present authors have thus compiled a computer database based on his archive, and this has formed the starting point of the present book. The book focuses on Knuth’s most substantial contribution to archaeology: the prehistory of Peary Land and adjacent areas.
In the catalogue emphasis has been placed on topographical and architectural information, site structure, artefact statistics and  radiocarbon dates. A total of 154 archaeological sites are presented. 51 sites with a total of 244 features are Independence I sites (c. 2460-1860 cal. BC), 23 sites with a total of 416 features belong to Independence II (c. 900-400 cal. BC) and 63 sites with a total of 626  features are of Thule origin (c. 1400-1500 cal. AD).
It has not been our ambition to re-analyse the finds or add new empirical data in connection with the production of this book. We do,  however, present some new information on the faunal material from Peary Land based at Christyann Darwent’s recent analyses as well as new data on the dwelling features on the Adam C. Knuth Site, which was visited by a multidisciplinary team in 2001.
The book is provided with an introduction presenting an overview and evaluation of Knuth’s remarkable curriculum vitae as an independent arctic archaeologist.
In the concluding chapters some basic statistics on the archaeological sites are presented. We evaluate Knuth’s radiocarbon dates for  of the Independence I, Independence II and Thule cultures in High Arctic Greenland, and settlement distributions and settlement patterns for the three cultures represented in Peary Land are discussed.
Phasing out the colonial status of Greenland. A historical study
Authors: Beukel Erik , Jensen Frede P. , Rytter Jens Elo
Published: October 2024

In 2005 the Danish government obliged the wish of the Greenlandic Home Rule to commission a historical report on the circumstances  surrounding the changed status of Greenland within the realm following the modification of the Constitution in 1953. The report  presented here provides the most comprehensive account to date of the decolonisation of Greenland's status in the years 1945-54.
With the Constitution of 1953, the colonial status of Greenland came to an end, and Greenlanders were granted equal rights as citizens  within the Danish realm. In 1954 this new arrangement was supported by the UN General Assembly. The decision to change  Greenland's status was conditioned both by internal and external circumstances. In the UN context, Danes increasingly felt the strain  of being a colonial power, and they feared the possibility of future UN interference in Greenlandic affairs.
The volume is a significant contribution to the ongoing debates concerning important developments in Danish-Greenlandic relations in the post-war period. It constitutes an important attempt to untangle the many circumstances impinging on the phasing out of  Greenland's colonial status.
Le droit à l’égalité après l’arrêt Ward : lumière sur les conséquences moins visibles de ce jugement
Authors: Fournier Stéphanie , St-Laurent Geneviève , Clément-Major Lysiane
Published: October 2024

La décision Ward a mis en lumière la difficile conciliation entre la liberté d’expression d’un humoriste et la sauvegarde de la dignité en pleine égalité d’un jeune enfant handicapé. La conclusion de cette saga judiciaire est toutefois venue avec un lourd prix à payer pour le droit à l’égalité. Le recadrage juridique imposé par la Cour suprême du Canada, par l’entremise des moyens choisis pour trancher ce litige, est de nature à fragiliser le droit à l’égalité énoncé à l’article 10 de la Charte québécoise. L’arrêt remet en question des principes phares de la protection contre la discrimination et importe dans notre droit de nouveaux éléments inattendus qui sont de nature à amoindrir la protection accordée au droit à l’égalité dans d’autres contextes. C’est sur ces conséquences moins visibles du jugement que porte ce texte.
Fin de la partie pour les Dark Patterns ?
Authors: Burelli Thomas , Dykukha Marie , Liu Haoran
Published: October 2024

Depuis les années 1970, le marché des jeux vidéo considérablement a évolué. Il a notamment vu l’émergence de nouveaux modèles d’exploitation et de monétisation au cours des années 2000. Selon les nouveaux modèles d’exploitation, les jeux vidéo sont considérés comme un service et non plus comme un produit vendu aux consommateurs une fois pour toutes. Les studios ayant adopté ces nouveaux modèles d’exploitation des jeux vidéo ont mis au point diverses stratégies — qualifiées par les auteurs de Dark Patterns — visant à maximiser l’engagement des joueurs et leurs dépenses dans les jeux. Quelques études récentes ont commencé à établir un lien entre les Dark Patterns et des effets psychiques et physiques délétères chez les joueurs. Ils peuvent notamment les conduire à perdre le contrôle du temps consacré à la pratique des jeux vidéo, ainsi que de leurs dépenses. Face à l’usage de ces Dark Patterns dans les jeux vidéo et leurs effets auprès des joueurs, il est important de se demander dans quelle mesure ce phénomène est pris au sérieux par les acteurs de l’industrie et les autorités publiques. Ont-ils conscience de ce phénomène et, le cas échéant, que font-ils pour lutter contre la présence et les effets des Dark Patterns dans les jeux vidéo? Pour répondre à ces questions, nous nous intéresserons d’abord aux pratiques des acteurs de l’industrie des jeux vidéo. Nous étudierons dans cette contribution l’utilisation de ces Dark Patterns et des mesures de régulation mises en place par les acteurs de l’industrie, le cas échéant. Dans un second temps, nous nous intéresserons aux stratégies et aux mesures adoptées par les autorités publiques dans les plus grands marchés de jeux vidéo à travers le monde, soit les États-Unis, l’Union européenne, la Chine, la Corée et le Japon. Nous verrons que diverses stratégies plus ou moins globalisées et plus ou plus moins coercitives sont aujourd’hui déployées pour lutter contre l’usage des Dark Patterns dans les jeux vidéo.
Plectin-mediated cytoskeletal crosstalk as a target for inhibition of hepatocellular carcinoma growth and metastasis
Authors: Outla Zuzana , Oyman-Eyrilmez Gizem , Korelova Katerina , Prechova Magdalena , Frick Lukas , Sarnova Lenka , Bisht Piyush , Novotna Petra , Kosla Jan , Bortel Patricia , Borutzki Yasmin , Bileck Andrea , Gerner Christopher , Rahbari Mohammad , Rahbari Nuh , Birgin Emrullah , Kvasnicova Bibiana , Galisova Andrea , Sulkova Katerina , Bauer Andreas , Jobe Njainday , Tolde Ondrej , Sticova Eva , Rosel Daniel , O’Connor Tracy , Otahal Martin , Jirak Daniel , Heikenwälder Mathias , Wiche Gerhard , Meier-Menches Samuel M , Gregor Martin
Published: October 2024

The most common primary malignancy of the liver, hepatocellular carcinoma (HCC), is a heterogeneous tumor entity with high metastatic potential and complex pathophysiology. Increasing evidence suggests that tissue mechanics plays a critical role in tumor onset and progression. Here we show that plectin, a major cytoskeletal crosslinker protein, plays a crucial role in mechanical homeostasis and mechanosensitive oncogenic signaling that drives hepatocarcinogenesis. Our expression analyses revealed elevated plectin levels in liver tumors, which correlated with poor prognosis for HCC patients. Using autochthonous and orthotopic mouse models we demonstrated that genetic and pharmacological inactivation of plectin potently suppressed the initiation and growth of HCC. Moreover, plectin targeting potently inhibited the invasion potential of human HCC cells and reduced their metastatic outgrowth in the lung. Proteomic and phosphoproteomic profiling linked plectin-dependent disruption of cytoskeletal networks to attenuation of oncogenic FAK, MAPK/Erk, and PI3K/AKT signatures. Importantly, by combining cell line-based and murine HCC models, we show that plectin inhibitor plecstatin-1 (PST) is well-tolerated and capable of overcoming therapy resistance in HCC. In conclusion, our study demonstrates that plectin-controlled cytoarchitecture is a key determinant of HCC development and suggests that pharmacologically induced disruption of mechanical homeostasis may represent a new therapeutic strategy for HCC treatment.
Molecular basis of neurodegeneration in a mouse model of Polr3-related disease
Authors: Moir Robyn D , Merheb Emilio , Chitu Violeta , Stanley E Richard , Willis Ian M
Published: October 2024

Pathogenic variants in subunits of RNA polymerase (Pol) III cause a spectrum of
Polr3
-related neurodegenerative diseases including 4H leukodystrophy. Disease onset occurs from infancy to early adulthood and is associated with a variable range and severity of neurological and non-neurological features. The molecular basis of
Polr3
-related disease pathogenesis is unknown. We developed a postnatal whole-body mouse model expressing pathogenic
Polr3a
mutations to examine the molecular mechanisms by which reduced Pol III transcription results primarily in central nervous system phenotypes.
Polr3a
mutant mice exhibit behavioral deficits, cerebral pathology and exocrine pancreatic atrophy. Transcriptome and immunohistochemistry analyses of cerebra during disease progression show a reduction in most Pol III transcripts, induction of innate immune and integrated stress responses and cell type-specific gene expression changes reflecting neuron and oligodendrocyte loss and microglial activation. Earlier in the disease when integrated stress and innate immune responses are minimally induced, mature tRNA sequencing revealed a global reduction in tRNA levels and an altered tRNA profile but no changes in other Pol III transcripts. Thus, changes in the size and/or composition of the tRNA pool have a causal role in disease initiation. Our findings reveal different tissue- and brain region-specific sensitivities to a defect in Pol III transcription.
HiExM: high-throughput expansion microscopy enables scalable super-resolution imaging
Authors: Day John H , Della Santina Catherine Marin , Maretich Pema , Auld Alexander L , Schnieder Kirsten K , Shin Tay , Boyden Edward S , Boyer Laurie A
Published: October 2024

Expansion microscopy (ExM) enables nanoscale imaging using a standard confocal microscope through the physical, isotropic expansion of fixed immunolabeled specimens. ExM is widely employed to image proteins, nucleic acids, and lipid membranes in single cells; however, current methods limit the number of samples that can be processed simultaneously. We developed High-throughput Expansion Microscopy (HiExM), a robust platform that enables expansion microscopy of cells cultured in a standard 96-well plate. Our method enables ∼4.2x expansion of cells within individual wells, across multiple wells, and between plates. We also demonstrate that HiExM can be combined with high-throughput confocal imaging platforms to greatly improve the ease and scalability of image acquisition. As an example, we analyzed the effects of doxorubicin, a known cardiotoxic agent, on human cardiomyocytes (CMs) as measured by Hoechst signal across the nucleus. We show a dose dependent effect on nuclear DNA that is not observed in unexpanded CMs, suggesting that HiExM improves the detection of cellular phenotypes in response to drug treatment. Our method broadens the application of ExM as a tool for scalable super-resolution imaging in biological research applications.
PVN-mPFC OT projections modulate pup-directed pup care or attacking in virgin mandarin voles
Authors: Li Lu , Li Yin , Huang Caihong , Hou Wenjuan , Lv Zijian , Zhang Lizi , Qu Yishan , Sun Yahan , Huang Kaizhe , Han Xiao , He Zhixiong , Tai Fadao
Published: October 2024

Many species of animals exhibit caregiving or aggression toward conspecific offspring. The neural mechanisms underlying the infanticide and pup care remain poorly understood. Here, using monogamous mandarin voles (Microtus mandarinus), we found that more oxytocin (OT) neurons in the paraventricular nucleus (PVN) were activated during pup caring than infanticide. Optogenetic activation of OT neurons in the PVN facilitated pup caring in male and female mandarin voles. In infanticide voles, optogenetic activation of PVN OT cells or PVN-medial prefrontal cortex (mPFC) OT projection fibers prolonged latency to approach and attack pups, whereas inhibition of these OT neurons or projections facilitated approach and infanticide. Optogenetic activation of PVN OT neuron projections to the mPFC in males shortened the latency to approach and retrieve pups and facilitated the initiation of pup care, but produced no effects on pup-care females. In addition, OT release in the mPFC increased upon approaching and retrieving pups, and decreased upon attacking pups. Intraperitoneal injection of OT promoted pup care and inhibited infanticide behavior. It is suggested that the OT system, especially PVN OT neurons projecting to mPFC, modulates pup-directed behaviors and OT can be used to treat abnormal behavioral responses associated with some psychological diseases such as depression and psychosis.
The ECO_CARE Participation in the G20 Delegation to Brazil
Authors: Poto Margherita Paola , Parola Giulia , Chue Muquissai Silvano , Médici Machado Natalia , Lima Gonçalves Adelson , Tavares Rodrigo
Published: October 2024

This report outlines the various activities coordinated by the ECOCARE team during the G20 Norwegian delegation’s visit to Brazil. The events were co-organized by the Norwegian Ministry of Education and Research, the Norwegian Agency for Higher Education and Skills (HKDIR), The Norwegian Research Council, and Innovation Norway. The series that involved our ECOCARE team members included two seminars: one held in Rio at PUC with the coordination of Margherita Paola Poto, Silvano Chue Muquissai, Rodrigo Tavares, and Natalia Médici Machado; and another at Manaus, UFAM, coordinated by Giulia Parola and Margherita Paola Poto, with contributions from Ragnhild Tungesvik and Adelson Lima Gonçalves. These events served to strengthen both old and new connections and solidified a shared commitment to collaborate with Indigenous scholars and students from Brazil and Norway, as well as with academic institutions, towards fostering a just world and a sustainable Planet.
fMRI-based Alzheimer’s disease detection via functional connectivity analysis: a systematic review
Authors: Alarjani Maitha , Almarri Badar
Published: October 2024

Alzheimer’s disease is a common brain disorder affecting many people worldwide. It is the primary cause of dementia and memory loss. The early diagnosis of Alzheimer’s disease is essential to provide timely care to AD patients and prevent the development of symptoms of this disease. Various non-invasive techniques can be utilized to diagnose Alzheimer’s in its early stages. These techniques include functional magnetic resonance imaging, electroencephalography, positron emission tomography, and diffusion tensor imaging. They are mainly used to explore functional and structural connectivity of human brains. Functional connectivity is essential for understanding the co-activation of certain brain regions co-activation. This systematic review scrutinizes various works of Alzheimer’s disease detection by analyzing the learning from functional connectivity of fMRI datasets that were published between 2018 and 2024. This work investigates the whole learning pipeline including data analysis, standard preprocessing phases of fMRI, feature computation, extraction and selection, and the various machine learning and deep learning algorithms that are used to predict the occurrence of Alzheimer’s disease. Ultimately, the paper analyzed results on AD and highlighted future research directions in medical imaging. There is a need for an efficient and accurate way to detect AD to overcome the problems faced by patients in the early stages.