bluuebunny/crossref_metadata_2025 huggingface dataset:
The problem of modern corporate education humanization
Authors: Rubantsova T. A.
Published: February 2021

There is not enough systematic philosophical research in the scientific works that fully consider the problems of the corporate education forming and peculiarities of its functioning. The article presents the socio-philosophical approach to analyze the problems of the corporate education humanization in the modern information society. To understand the corporate education as a socio-philosophical phenomenon, it is necessary to find out the prerequisites for its emergence, conditions of its formation and development process. To do this, a systematic philosophical approach should be used based on the research analysis both in social philosophy, and related fields. The study of this problem is a complex cognitive process necessary for the cor porate education philosophical analysis. The article considers the basic categories for the socio-philosophical analysis of this phenomenon, such as, «social reality», «education», «continuing education», «corporate education» etc. The authors conclude that there is a steady trend of institutionalization and humanization of this social phenomenon as a result of the corporate education actively developing problem in the context of the information and communication society. An analysis of modern foreign and domestic scientific literature allows concluding that each country has a certain specificity of the corporate education, which is due to cultural characteristics, mentality, economy and the technology and production development level.
Features of using multimedia presentations and electronic textbooks to teach foreign citizens in Russian universities
Authors: Novichkova T. Yu. , Shchipanova E. V. , Bochkareva O. V. , Tsarapkina Ju. M. , Mironov A. G.
Published: February 2021

The article raises the problem of training cadets of the CIS countries who receive higher education in military universities of our country. Russian language proficiency is the main problem, as the training is exclusively in Russian, and as part of a Russian group. Language acquisition occurs gradually during interpersonal communication, and most of all, at classes. One of the first subjects that cadets start studying is mathematics. The main feature of mathematics is the universality of formulas for communication in its language both in the CIS countries and in the world. It greatly simplifies the process of transmitting information to students, allows the teacher to minimize the number of Russian words at the first stages of training (first year of training) gradually raising the volume of definitions and theorems. The great majority of students from the CIS countries freely perceive the lecture and fully assimilate the information even in such a section of «Higher mathematics»as probability theory by the end of the second year. The article shows the transition from the overwhelming number of formulas in the lectures to the prevalence of definitions and theorems. The number of Russian words also increases at practical classes. Their introduction is based on drawings (topic «Analytical geometry»), graphs («Introduction to mathematical analysis», «Definite integral »). The laboratory works are of the greatest interest, of course, where students must draw conclusions about the suitability of the formula obtained as the experiment result. The article details the methodological features of organizing various types of classes using multimedia tools and electronic textbooks in groups with cadets from the CIS countries.
Rank analysis in evaluating the validity of olympiad tasks
Authors: Gurina R. V. , Morozova E. V. , Kosheva V. V.
Published: February 2021

The rank analysis (cenological approach) based on a strict mathematical apparatus allows diagnosing the state of educational systems and processes on a scientific objective basis. The rank analysis base is applying the law of hyperbolic rank distribution of objects in systems-cenoses, which is a refined Pareto law 20/80 (Pareto-Kudrin law). Using of rank analysis to evaluate the validity of the olympiad tasks of the all-Russian Multidisciplinary Engineering Olympiad «Star», the authors demonstrate the necessity of implementing rank analysis in the practice of education quality management. They show that this law is important and appropriate to apply in the education quality management. Optimization of educational systems and processes using rank analysis consists in eliminating anomalous deviations from the hyperbolic law, which is possible only with graphical visualization of the rank distribution and its approximation. The rank distribution graph provides visibility and insight into the nature of the rank decrease. Shortcomings in the content of olympiad tasks (as well as tests), leading to a deterioration of their validity and reliability, are shown the form of distortions of the hyperbolic graph (humps, depressions, tails, degeneration of the hyperbola into other dependencies). The rank analysis allows identifying objectively several levels of validity of olympiad or test tasks carrying on a scientific basis. The paper demonstrates graphs of run distributions illustrating examples of high (natural science) and below the average (history) validity of olympiad tasks. Educational systems are cenoses, ranking objects in them are students, classes, schools, etc., and their ranked parameters are academic performance, rating in points, performance indicators, etc. Using simple mathematical tools of rank analysis and computer software bring the technologies to assess the education quality to a higher level meeting the challenges of the time.
The Alignment between Agricultural Policy and the SDGs: Zero Hunger and Responsible Production and Consumption in Ecuador
Authors: Requelme Narcisa , Afonso Ana
Published: February 2021

This study reviews how policy and agricultural laws relate to Sustainable Development Goals (SDGs) 2 and 12, sustainability and rural development, in Ecuador. Policy aligns itself with goals 2 in terms of increased productivity and income (target 2,3) to interna-tional markets (targets 2b y 2c), rural infrastructure, research, agricultural extension and technological development (target 2a), agrobiodiversity and traditional knowledge (target 25). It is related with SDG 12 to sustainable production and consumption targets 12.1, 12.2 and 12a). Laws highlight public procurement, research, seeds, and efficient resource management through sustainable practices. It is concluded that policy is aligned with SDGs 2 and 12 but is necessary to establish others that surpass the emphasis on produc-tivity towards export markets that leave AFC production and achieve a transition to sus-tainable production and consumption. The study of laws indicates that it is necessary to strengthen local governance for food sovereignty, including the peasant sectors within the framework of existing laws with participation in spaces of debate and formulation of ac-tions.
The Role of Rotational Thromboelastometry (ROTEM) in Understanding the Coagulation Problems in COVID-19 Associated Critical Illness
Authors: Duric Natalie , Szakmany Tamas
Published: February 2021

In critically ill patients with COVID-19, concomitant abnormalities of coagulation have been seen with an unusually high incidence. Standard coagulation tests are limited in their ability accurately to reflect the severity of the pro-thrombotic phenotype observed in severe COVID-19 infections. In this narrative review we consider the role of rotational thromboelastometry (ROTEM) as a near bedside test allowing a more comprehensive assessment of haemostatic function in the context of COVID-19 infection. Comprehensive literature search was conducted on PubMed, revealing 13 publications on the subject. The coagulopathy of this disease process appears to be insufficiently represented with often normal conventional coagulation test parameters. Whilst not the perfect substitute for in vivo coagulation, studies utilising rotational thromboelastometry assays in COVID-19 patients have demonstrated increased maximum clot firmness (consistent with hyper-coagulability) and reduced maximum lysis (consistent with “fibrinolytic shutdown”). ROTEM appears to be a possible tool for risk stratification and to monitor the potential modulation of fibrinogen-dependent coagulation processes with enhanced anti-coagulation strategies. Precisely how these coagulation abnormalities can be modified by optimum, individualised medical interventions to improve clinical outcome, however, remains unclear.
Dirac Oscillator in Dynamical Noncommutative Space
Authors: Haouam Ilyas
Published: February 2021

In this paper, we address the energy eigenvalues of two-dimensional Dirac oscillator perturbed by dynamical noncommutative space. We derived the relativistic Hamiltonian of Dirac oscillator in dynamical noncommutative space ( τ -space), in which the space-space Heisenberg–like commutation relations and noncommutative parameter are position-dependent. Then used this Hamiltonian to calculate the first-order correction to the eigenvalues and eigenvectors, based on the second quantization and using the perturbation theory. It is shown that the energy shift depends on the dynamical noncommutative parameter τ . Knowing that with a set of two-dimensional Bopp-shift transformation, we mapped the noncommutative problem to the standard commutative one.
BAGAIMANA DAMPAK TRANSAKSI NON TUNAI DAN INFLASI TERHADAP JUMAH UANG YANG BEREDAR
Authors: Fatmawati Meilinda Nur Rasyida , Indah Yuliana
Published: February 2021

ABSTRAK

Transaksi non tunai kini semakin banyak digunakan dalam bertransaksi. Selain lebih praktis, mudah dan cepat, transaksi non tunai memiliki pengaruh terhadap kebijakan moneter di Indonesia. Dalam kebijakan moneter, transaksi non tunai mempengaruhi tingkat jumlah uang beredar di masyarakat. Selain itu, terdapat faktor lain yang dapat mempengaruhi jumlah uang beredar yaitu inflasi. Transaksi non tunai pada penelitian ini menggunakan ATM debet, ATM kredit dan uang elektronik. Tujuan penelitian ini adalah untuk mendapatkan bukti pengaruh transaksi non tunai terhadap jumlah uang beredar di Indonesia dengan inflasi sebagai variabel moderasi selama tahun 2015- 2018. Pengumpulan data menggunakan data sekunder dan teknik analisis yang digunakan adalah uji Moderating Regression Analysis (MRA). Berdasarkan hasil penelitian yang telah dilakukan adalah transaksi non tunai memiliki pengaruh positif dan signifikan terhadap jumlah uang beredar dan inflasi mampu memperkuat hubungan transaksi non tunai terhadap jumlah uang beredar.

 

Kata Kunci: ATM debet. ATM kredit, uang eletronik, inflasi, jumlah uang beredar (M1)

 

ABSTRACT

The use of Non-cash transactions in society are increasing recently. It is more practical, easy and fast, moreover non-cash transactions have an influence on monetary policy in Indonesia. In monetary policy, non-cash transactions affect the level of money supply. In addition, there are other factors that can affect the money supply, namely inflation. Non-cash transactions in this study use a debit ATM, credit ATM and electronic money. The purpose of this study is to obtain evidence of the effect of non-cash transactions on the money supply in Indonesia with inflation as a moderating variable during 2015-2018. Data collection is based on secondary data and the analysis technique used is Moderating Regression Analysis (MRA) test. This research results that non-cash transactions have a positive and significant effect on the money supply and inflation is able to strengthen the relationship of non-cash transactions and the money supply.

Keywords: Debit AT, ATM credit, electronic money, inflation, money supply (M1)
PENGARUH KEPUTUSAN INVESTASI, KEPUTUSAN PENDANAAN, KEBIJAKAN DIVIDEN, DAN UKURAN DEWAN KOMISARIS TERHADAP NILAI PERUSAHAAN PADA PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BURSA EFEK INDONESIA PERIODE 2016-2018
Authors: Gatot Nazir Ahmad  , Rizal Lullah  , M. Edo S. Siregar
Published: February 2021

Penelitian ini bertujuan untuk mengetahui Pengaruh Keputusan Investasi, Keputusan Pendanaan, Kebijakan Dividen, dan Ukuran Dewan Komisaris Terhadap Nilai Perusahaan pada Perusahaan Manufaktur yang Terdaptar Di Bursa Efek   Indonesia   Periode   2016-2018.   Variabel   bebas   yang   digunakan  pada penelitian ini adalah Keputusan Investasi (PER), Keputusan Pendanaan (DER), Kebijakan Dividen (DPR), dan Ukuran Dewan Komisaris. Variabel terikat yang digunakan adalah Nilai Perusahaan (PBV).  Metode pengambilan sampel yang digunakan dalam penelitian ini menggunakan teknik Purposive Sampling, dan diperoleh jumlah sampel sebanyak 70 perusahaan. Teknik analisis yang digunakan dalam penelitian ini adalah regresi data panel. Hasil penelitian ini menunjukan bahwa Keputusan Ivestasi dengan proksi PER berpengaruh signifikan positif terhadap Nilai Perusahaan, Keputusan Pedanaan dengan proksi DER tidak berpengaruh signifikan negatif terhadap Nilai Perusahaan, Kebijakan Dividen dengan proksi DPR tidak berpengaruh signifikan negatif terhadap Nilai Perusahaan,   dan   Ukuran   Dewan   Komisaris   berpengaruh   signifikan   positif terhadap Nilai Perusahaan (PBV).
Self-Efficacy with Achievement Motivation in Students Working VIII Semester Faculty of Economics and Business, Faculty of Engineering and Faculty of Teacher Training and Education at Muhammadiyah University, Sidoarjo
Authors: Dewi Ananda Putri Aisyah , Ansyah Eko Hardi
Published: February 2021

This study aims to determine the relationship between self-efficacy and achievement motivation and how much influence self-efficacy on achievement motivation on eighth semester student students at the Faculty of Economics and Business, Faculty of Engineering and Faculty of Teacher Training and Education Sciences at Muhammadiyah University Sidoarjo. This research was conducted with a quantitative correlational research method, using simple random sampling with a sample of 227 students. The measuring instrument uses two scales, self-efficacy scale and achievement motivation scale with Pearson product moment correlation technique with the help of IBM Statistics 20 Version for Windows. The results of the analysis show that there is a relationship between self-efficacy and achievement motivation. The implications of this study is to develop student achievement and provide interventions to improve the quality of education. Maximum improvement of education qualification can improve self-efficacy and achievement motivation in working students
The Relationship Between Emotional Intelligence and Cyberbullying Behavior in Adolescents in Salatiga
Authors: Sting Nataliinn
Published: February 2021

This study is conducted to examine the correlation between emotional intelligence and cyberbullying behaviour among teenagers in Salatiga. It involved 405 teenagers aged 15-17 years old (247 girls and 158 boys). Data were taken using The Assessing Emotion Scale of Schutte, Malouff, dan Bhullar (2009), consisted of 33 items with validity coefficient 0,843, to examine validity coefficient, and The Cyber-Bullying Questionnaire of Esther Calvete, Izaskun Orue, Ana Estévez, Lourdes Villardón, and Patricia Padilla (2010), consisted of 16 items with validity 0,839, to examine the variable of the behaviour. It was analyzed using Spearman's rank correlation coefficient in SPSS 16.0 for windows. The results showed a significant negative correlation between emotional intelligence and cyberbullying behaviour with rxy = -0,126 dan p = 0,006 (p < 0,05).
High copy number variations, particular transcription factors, and low immunity contribute to the stemness of prostate cancer cells.
Authors: Dai Zao , Liu Ping
Published: February 2021

Background: Tumor metastasis is the main cause of death of cancer patients, and the existence of cancer stem cells is the basis of tumor metastasis. However, the systematic analysis of the stemness of prostate cancer cells is still not abundant. This article explores the effective factors that lead to the stemness of prostate cancer cells with multi-omics data mining.Methods: Gene expression modules that were strongly related to the stemness of prostate cancer cells were obtained with WGCNA and stemness scores, based on the prostate cancer transcriptome data in TCGA. Calculated the copy number variation of stemness genes of prostate cancer and evaluated the difference of transcription factors in prostate cancer and normal tissues, based on CNV (copy number variation) data and ATAC-seq data. The protein interaction network of stemness genes of prostate cancer was constructed with the STRING database. At the same time, the correlation between stemness genes of prostate cancer and immune cells was analyzed.Results: Prostate cancer with high Gleason grade was more stemness. The gene set highly related to prostate cancer stemness had higher CNV in prostate cancer samples than normal samples. The transcription factors of stemness genes had similar expressions but had different contributions in normal and prostate cancer tissues. And particular transcription factors enhanced the stemness of prostate cancer, such as PUM1, CLOCK, SP1, TCF12, and so on. The lower tumor immune microenvironment was conducive to the stemness of prostate cancer, and CD8+ T cells and M1 macrophages might play an important role than other immune cells in the tumor microenvironment. We also found that EZH2 played a central role in stemness genes and was negatively correlated with resting mast cells and positively correlated with activated memory CD4+ T cells.Conclusions: This study found that high copy number variation, specific transcription factors, and low immune microenvironment contributed to the stemness of prostate cancer cells through systematic multi-omics analysis. These findings would provide new clues and directions for future research of prostate cancer stem cells.
Genome-wide analysis identifies critical DNA methylations within NTRKs genes in colorectal cancer
Authors: Chen Zijian , Huang Zenghong , Luo Yanxin , Zou Qi , Bai Liangliang , Tang Guannan , Wang Xiaolin , Cao Guangwen , Huang Meijin , Xiang Jun , Yu Huichuan
Published: February 2021

Background: Neurotrophic tropomyosin receptor kinases (NTRKs) are a gene family function as oncogene or tumor suppressor gene in distinct cancers. We aimed to investigate the methylation and expression profiles and prognostic value of NTRKs gene in colorectal cancer (CRC).Methods: An analysis of DNA methylation and expression profiles in CRC patients was performed to explore the critical methylations within NTRKs genes. The methylation marker was validated in a retrospectively collected cohort of 229 CRC patients and tested in other tumor types from TCGA. DNA methylation status was determined by quantitative methylation-specific PCR (QMSP).Results: The profiles in six CRC cohorts showed that NTRKs gene promoter was more frequently methylated in CRC compared to normal mucosa, which was associated with suppressed gene expression. We identified a specific methylated region within NTRK3 promoter targeted by cg27034819 and cg11525479 that best predicted survival outcome in CRC. NTRK3 promoter methylation showed independently predictive value for survival outcome in the validation cohort (P = 0.004, HR = 2.688, 95% CI = [1.355, 5.333]). Based on this, a nomogram predicting survival outcome was developed with a C-index of 0.705. Furthermore, the addition of NTRK3 promoter methylation improved the performance of currently-used prognostic model (AIC: 516.49 vs 513.91; LR: 39.06 vs 43.64, P = 0.032). Finally, NTRK3 promoter methylation also predicted survival in other tumors, including pancreatic cancer, glioblastoma and stomach adenocarcinoma.Conclusions: This study highlights the essential value of NTRK3 methylation in prognostic evaluation and the potential to improve current prognostic models in CRC and other tumors.
Detection of SARS-CoV-2-specific antibodies via rapid diagnostic immunoassays in COVID-19 patients
Authors: Chansaenroj Jira , Yorsaeng Ritthideach , Posuwan Nawarat , Puenpa Jiratchaya , Sudhinaraset Natthinee , Chirathaworn Chintana , Poovorawan Yong
Published: February 2021

Background: Efficient monitoring and control of coronavirus disease 2019 (COVID-19) require access to diagnostic tests, and serological diagnostic testing is desirable. In the current study, antibodies were investigated in patients recently diagnosed with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.Methods: Cross-sectional data were obtained from 245 patients in whom SARS-CoV-2 infection had been confirmed via real-time reverse transcriptase-polymerase chain reaction between March and October 2020. Serum samples were acquired between 2 and 60 days following the onset of COVID-19 symptoms or the first detection of SARS-CoV-2 in asymptomatic patients. All specimens were tested simultaneously using an IgM/IgG rapid diagnostic test (RDT), IgG nucleocapsid protein-based chemiluminescent microparticle immunoassay (CMIA), IgG, and IgA spike protein-based enzyme-linked immunosorbent assays (ELISAs). Blood donor samples obtained in 2018 were used as negative controls. Results: The sensitivity and specificity of the RDT IgG were compared with the IgG immunoassays as standards. The RDT IgG exhibited 97.5% sensitivity and 89.4% specificity compared with a CMIA IgG, 98.4% sensitivity, and 78.8% specificity compared with an ELISA IgG. IgM, IgG, and IgA seropositivity rates were low between 1-2 weeks after COVID-19 symptom onset or the detection of SARS-CoV-2 RNA. IgM seropositivity rate began decreasing after 4 weeks, whereas IgG and IgA seropositivity rate remained at appreciable levels over the 8-week study period. No cross-reactivity with seasonal coronaviruses was detected.Conclusions: IgM/IgG RDTs alone or combined with molecular diagnostic tests may be useful for identifying recent SARS-CoV-2 infection.
Effect of denosumab switched from bisphosphonates in preventing joint destruction in postmenopausal rheumatoid arthritis patients with anti-cyclic citrullinated peptide antibodies
Authors: Mori Yu , Izumiyama Takuya , Kurishima Hiroaki , Kamimura Masayuki , Baba Kazuyoshi , Mori Naoko , Itoi Eiji
Published: February 2021

Introduction: This study aimed to determine the effects of denosumab treatment on the joint destruction of Japanese females with rheumatoid arthritis (RA) and anti-cyclic citrullinated peptide (CCP) antibodies. Materials and Methods: This retrospective longitudinal study included 56 patients treated with denosumab and 50 patients treated with bisphosphonate. All participants were positive for anti-CCP antibodies. All patients also had a history of osteoporosis treatment with bisphosphonate, which was either continued or switched to 60 mg of subcutaneous denosumab injection every 6 months. To assess the progression of joint destruction, hand and foot radiographs were taken, and changes in modified total Sharp score (mTSS), erosion score (ERO) and joint space narrowing score (JSN) were evaluated at 12 months and 24 months. The changes in BMD of the lumbar spine and hip were also assessed at 12 months. Results: At 12 months, there were significant differences in the change of ERO (p = 0.015) and mTSS (p = 0.01). Similarly, there were significant differences in the change of ERO (p = 0.013) and mTSS (p = 0.003) at 24 months. In contrast, no significant difference was observed in the changes of JSN and clinical parameters. There were significant differences in the changes in BMD in the femoral neck (p = 0.011) and total hip (p = 0.012).Conclusion: Denosumab treatment might be effective for the inhibition of bone erosion progression in the patients with RA, and it potentially contributes to the treatment of osteoporosis and prevention of destructive arthritis in patients with switching treatment from bisphosphonate.
Synthesis, antibiotic structure-activity-relationships, and cellulose dissolution studies of new room-temperature ionic liquids derived from lignin
Authors: Liu Shihong , Gonzalez Michael , Kong Celine , Weir Scott , Socha Aaron
Published: February 2021

Background: Ionic liquids (ILs) are promising pretreatment solvents for lignocellulosic biomass, but are largely prepared from petroleum precursors. Benzaldehydes from depolymerized lignin, such as vanillin, syringaldehyde, and 4-methoxy benzaldehyde, represent renewable feedstocks for the synthesis of ionic liquids. We herein report syntheses of novel lignin-derived ionic liquids, with extended N-alkyl chains, and examine their melting points, cellulose dissolution capacities, and toxicity profiles against Daphnia magna and E. coli strain 1A1. The latter organism has been engineered to produce isoprenol, a drop-in biofuel and precursor for commodity chemicals. Results: The new N,N-diethyl and N,N-dipropyl methyl benzylammonium ILs were liquids at room temperature, showing 75-100oC decreased melting points as compared to their N,N,N-trimethyl benzylammonium analog. Extension of N-alkyl chains also increased antibacterial activity 3-fold, while ionic liquids prepared from vanillin showed 2- to 4-fold lower toxicity as compared to those prepared from syringaldehyde and 4-methoxybenzaldehyde. The trend of antibacterial activity for anions of lignin-derived ILs was found to be methanesulfonate < acetate < hydroxide. Microcrystalline cellulose dissolution, from 2-4 wt% after 20 min at 100oC, was observed in all new ILs using light microscopy and IR spectroscopy.Conclusions: Ionic liquids prepared from H-, S- and G-lignin oxidation products provided differential cytotoxic activity against E.coli and D. magna, suggesting these compounds could be tailored for application specificity within a biorefinery.
Electron Spin Resonance of Single Molecules and Magnetic Interaction through Ligands
Authors: Zhang Xue , Wolf Christoph , Wang Yu , Aubin Hervé , Bilgeri Tobias , Willke Philip , Heinrich Andreas , Choi Taeyoung
Published: February 2021

Electron spin resonance (ESR) spectroscopy is a crucial tool to determine the chemical structure of materials. ESR spectra measured in molecular systems, however, are established on large ensembles of spins and usually require complicated structural analysis. Recently, scanning tunneling microscopy (STM) combined with ESR has been proven as a powerful tool to image and coherently control individual atomic spins on surfaces. Here, we extend this technique to demonstrate ESR on single organic molecules - iron phthalocyanine (FePc) - and investigate the magnetic interactions between a molecular spin and either another molecular or atomic spin. We show that the molecular spin density is not only localized at the central Fe atom, but also distributed to the outer ligands, yielding a strongly anisotropic exchange coupling. Our work opens the door for using molecules in nanoscale ESR studies and promises tuning magnetic interactions between non-localized spins via tailoring ligand field symmetry and strength.
Simulation Studies 3D QSAR and Molecular Docking, on a Point Mutation of Protein Kinase B with Flavonoids Targeting Ovarian Cancer
Authors: Ajjarapu Suchitra , Tiwari Apoorv , Taj Gohar , Singh Dev , Singh Sakshi , Kumar Sundip
Published: February 2021

Cancer is the world’s dreaded disease and its prevalence is expanding globally. The study of integrated molecular networks is crucial for the basic mechanism of cancer cells and its progression. During the present investigation we have examined different flavonoids that targets protein kinases B (AKT1) protein which exerts their anticancer efficiency intriguing the role in cross talk cell signalling, by metabolic processes through in-silico approaches. Molecular dynamics simulation (MDS) was performed to analyse and evaluate the stability of the complexes under physiological conditions and the results were congruent with molecular docking. This investigation revealed the effect of a point mutation (W80R), considered based on their frequency of occurrence, with AKT1. The ligand with high docking scores and favourable behaviour on dynamic simulations are proposed as potential W80R inhibitors. A virtual screening analysis was performed with 12000flavonoids satisfying the Lipinski’s rule of 5 according to which drug-likeness is predicted based on its pharmacological and biological properties to be active and taken orally. The pharmacokinetic ADME (adsorption, digestion, metabolism and excretion) studies featured drug likeness. Subsequently, a statistical significant 3D-QSAR model of high correlation coefficient (R2) with 0.992 and cross validation coefficient (Q2) with 0.6132 at 4 component PLS (partial least square) were used to verify accuracy of the models. The molecular dynamics simulation of this study showed that the compound is Taxifolin (I-UPAC namely2-(3,4-dihydroxyphenyl)-3,4 –dihydro-2H-chromene-5,7-diol of C15H14O5, of CID ID-443637 evidenced a better interaction with docking score (-9.63Kcal/mol) exhibited the binding affinity with W80R mutant protein thus reflecting that natural inhibitor can be considered for experimental evaluation which provides targeted insights for new combination of drugs in forming a network in pharmacology.
Atomic-scale tandem regulation of anionic and cationic migration for long-life alkali metal batteries
Authors: Xiong Pan , Zhang Fan , Zhang Xiuyun , Liu Yifan , Wu Yunyan , Wang Shijian , Safaei Javad , Sun Bing , Ma Renzhi , Liu Zongwen , Bando Yoshio , Sasaki Takayoshi , Wang Xin , Zhu Junwu , Wang Guoxiu
Published: February 2021

Atomic-scale regulation of both cationic and anionic transport is of great significance in membrane-based separation technologies. Ionic transport regulation techniques could also play a crucial role in developing high-performance alkali metal batteries such as alkali metal-sulfur and alkali metal-selenium batteries, which suffer from the non-uniform transport of alkali metal ions and detrimental shuttling of polysulfide/polyselenide (PS) anions. These obstacles can cause severe growth of alkali metal dendrites and the irreversible consumption of active cathodes, leading to capacity decay and short cycling life. Herein, we report long-life alkali metal batteries enabled by atomic-scale tandem regulation of the migration of both alkali metal cations (Li+/Na+) and PS anions using negatively charged Ti0.87O2 nanosheets with Ti atomic vacancies. The shuttling of PS anions has been effectively eliminated via a robust electrostatic repulsion between the negatively charged nanosheets and PS anions. The negatively charged nanosheets can also regulate the migration of Li+/Na+ ions to ensure a homogeneous ion flux through efficient but light adhesion of Li+/Na+ ions within the nanosheets. The atomic Ti vacancies act as sub-nanometre pores to provide fast diffusion channels for Li+/Na+ ions. Therefore, eradication of PS shuttling and stable Li/Na-ion diffusion without compromising the fast transport of Li+/Na+ ions has been achieved for long-life alkali metal-sulfur and alkali metal-selenium batteries. This work provides a facile and effective strategy to regulate the transport of both cations and anions for developing advanced rechargeable batteries by using two-dimensional vacancy-enhanced materials.
WITHDRAWN: Nutrient removal effectivity of seaweeds as biofilter and water pollution control in hybrid grouper aquaculture wastewater at low salinity
Authors: Adharini Ratih Ida , Murwantoko Murwantoko , Probosunu Namastra , Setiawan Riza Yuliratno , Satriyo Tony Budi
Published: February 2021

This research aims to determine the performance and nutrient removal effectivity of seaweeds species, namely Ulva fasciata., Sargassum illicifolium, Gelidium sp., and Dictyota sp. as a biofilter in hybrid grouper aquaculture wastewater at low salinity (14-17 ppt). This study used a Completely Randomized Design with 3 replications. The statistical analysis was carried out by Analysis of Variance continued with the Least Significance Difference test, and the Kruskal-Walis test with the Mann-Whitney analysis, and T-test with a confidence level of 95%. The concentrations of ammonia, nitrate, phosphate, and water quality parameters were observed every 4 days. The seaweeds uptake of N and P in water, and Specific Growth Rate were also observed. The results showed that U. fasciata was able to reduce ammonia by 75.95% and nitrate by 79.53%, which were the highest compared to other treatments, while Dictyota sp. was able to reduce the highest phosphate by 87.5% for 20 days. The highest SGR was achieved by U. fasciata at 1.91 %day-1. The highest N content uptake by seaweeds was 104.4%, and the total P of 182.3% occurred in U. fasciata. Overall, U. fasciata has the highest performance and effectiveness as a biofilter that is able to reduce nutrient waste in low-salinity from grouper aquaculture, for re-circulation or before being discharged into the environment to reduce eutrophication and harmful Algal Blooms (HABs) in aquatic environment. The highest growth rate of U. fasciata can be used as food with highly nutritional and economical value.
Elimination of Glutamatergic Transmission From Hb9 Interneurons Does Not Impact Treadmill Locomotion
Authors: Koronfel Lina M , Kanning Kevin C , Alcos Angelita , Henderson Christopher E , Brownstone Robert M
Published: February 2021

The spinal cord contains neural circuits that can produce the rhythm and pattern of locomotor activity. It has previously been postulated that a rhythmogenic population of glutamatergic neurons, termed Hb9 interneurons, contributes to this rhythmogenesis. The homeobox gene, Hb9, is expressed in these interneurons as well as motor neurons. We developed a mouse line in which cre recombinase activity is inducible in neurons expressing Hb9. We then used this line to eliminate vesicular glutamate transporter 2 from Hb9 interneurons, and found that there were no deficits in treadmill locomotion. We conclude that glutamatergic neurotransmission by Hb9 interneurons is not required for locomotor rhythmogenesis. The role of these neurons in neural circuits remains elusive.
Psychological Distress and Health-Related Quality of Life Among Women With Breast Cancer: A Descriptive Cross-Sectional Study
Authors: Phoosuwan Nitikorn , Lundberg Pranee C.
Published: February 2021

Background: Globally, breast cancer is commonly found among women, and Sweden has the largest number of new cases diagnosed. Treatment leads to increased survival of patients, but they are at risk to experience psychological distress, including anxiety and depressive symptoms, and decreased health-related quality of life (HRQoL). This study investigated relationship between psychological distress and HRQoL, and related factors among women with breast cancer in Sweden.Methods: This descriptive cross-sectional study was conducted in Sweden. A total of 481 women with breast cancer from a list of a regional cancer centre answered a questionnaire about sociodemographic factors, social support, psychological distress and HRQoL. Data were subjected to Pearson’s correlation and linear regression analyzes. Results: Psychological distress was related to HRQoL in terms of body image, future perspective, side effects of systemic therapy, breast symptoms, arm symptoms, and hair loss. Lower age was likely to increase symptoms of anxiety, and undergone breast reconstruction was likely to increase symptoms of depression. Breast reconstruction and chemotherapy worsened body image, low support from partner decreased sexual functioning and enjoyment, and low support from physicians and nurses worsened future perspective, side effects of systemic therapy, breast symptoms and indignation about hair loss.Conclusions: Psychological distress were correlated with the HRQoL. Increased support from physicians, nurses, and partner may increase the HRQoL among women with breast cancer. Treatments of women with breast cancer, such as breast reconstruction and chemotherapy were factors that decreased the psychological distress and increased the HRQoL.
Sustainability in Quality Improvement (SusQI): A Case-study in Undergraduate Medical Education
Authors: Clery Philippa , ArchSmith Stuart d' , Marsden Oliver , Leedham-Green Kathleen
Published: February 2021

BackgroundThere is a pressing need for more sustainable healthcare. UK medical graduates are required to apply social, economic and environmental principles of sustainability to their practice. The Centre for Sustainable Healthcare has developed a sustainability in quality improvement (SusQI) framework and educator’s toolkit to address these challenges. We aimed to evaluate this toolkit at Bristol Medical School.MethodsWe facilitated a SusQI workshop for all third-year Bristol Medical School students. We used mixed methods including questionnaires, exit interviews and follow-up focus groups to evaluate the outcomes and processes of learning.ResultsStudents reported: improvements in knowledge, confidence, and attitudes in both sustainable healthcare and quality improvement; increased self-rated likelihood to engage in SusQI projects; and willingness to change behaviour to reduce environmental impact in their healthcare roles. Factors for successful teaching included: interactivity; collaboration and participation; and real-life, relevant and tangible examples of projects delivered by credible role models.ConclusionsSusQI education supported by the toolkit was effective at building knowledge and skills, and reframing thinking on sustainability in quality improvement. Combining the topics provided enhanced motivation for and engagement in both together, not only each individually. Further research is needed on translation of SusQI learning into practice.
The impact of hearing impairment and hearing aid use on progression to mild cognitive impairment in cognitively healthy adults: a longitudinal study of 5721 participants
Authors: Bucholc Magda , Bauermeister Sarah , Kaur Daman , McClean Paula , Todd Stephen
Published: February 2021

The increasing prevalence of dementia in older adults warrants attention to the identification of practices that can delay or reduce likelihood of progression to early forms of cognitive impairment, in particular, to mild cognitive impairment (MCI) which is often considered a transitional stage between healthy aging and dementia. In this study, we investigated the effect of hearing impairment and hearing aid usage on cognitive decline and progression to MCI in cognitively healthy individuals. We used data from a large referral-based cohort obtained from the National Alzheimer’s Coordinating Center. The baseline sample included 5721 cognitively normal subjects aged ≥ 40. We found that hearing impairment was associated with increased risk of progression to MCI (hazard ratio [HR] = 1.40, 95%CI, 1.16-1.68, false discovery rate [FDR] P < 0.001) and an accelerated rate of cognitive decline (P < 0.001). Among hearing-impaired participants, hearing aid users were less likely to develop MCI (HR, 0.33; 95% CI, 0.23-0.47; FDR P < 0.001) and experienced slower cognitive decline (P = 0.004) when compared to those not using hearing aids. We found no statistically significant differences in risk of conversion to MCI between individuals with normal hearing and hearing-impaired adults using hearing aids (HR, 1.23; 95% CI, 0.99-1.50; FDR P = 0.08). Our findings highlight the need for a randomized clinical trial that will allow us to investigate whether there is a causal relationship between hearing loss, hearing aid use, and conversion to MCI. Such knowledge could provide new and novel insights into prevention of cognitive impairment and dementia.
Role of Autophagy in the Prognosis of Combined Hepatocellular Carcinoma and Cholangiocarcinoma after Surgical Resection
Authors: Perng Daw-Shyong , Lin Hung-Yu , Morgan Paul , Wu Tsung-Chin , Hung Chao-Ming , Hsieh Pei-Min , Yeh Jen-Hao , Hsiao Pojen , Lee Chih-Yuan , Li Yu-Chan , Wang Ya-Chin , Chen Yaw-Sen , Lin Chih-Wen
Published: February 2021

Background: Autophagy-related proteins may predict postresection overall survival (OS) and disease-free survival (DFS) in patients with combined hepatocellular carcinoma and cholangiocarcinoma (cHCC-CC). Methods: We prospectively investigated how these proteins affect clinical prognosis in 40 patients who underwent hepatectomy for cHCC-CC from 2011 to 2019 at a Taiwanese hospital. Levels of autophagy-related proteins, namely LC3, Beclin-1, and p62, were immunohistochemically assessed in patient tumor and non-tumor tissues. Results: We noted that LC3 expression was significantly correlated with mild clinicopathological characteristics, including macrovascular invasion, lymph node metastasis, American Joint Committee on Cancer and Barcelona Clinic Liver Cancer stages, recurrence, and mortality. Ten patient showed tumor recurrence, and 15 patients died. Postresection 5-year OS and DFS rates were 43.7% and 57.4%, respectively. Cox regression analysis showed that high intratumoral LC3 expression was significantly associated with improved OS [hazard ratio (HR; 95% confidence interval (CI)): (1.68–26.9), p = 0.007], but multiple tumors and microvascular invasion was significantly correlated with poor OS [HR (95% CI): 0.03 (0.01–0.34), p = 0.004, and 0.07 (0.01–0.46), p = 0.006, respectively]. Furthermore, high LC3 expression and cirrhosis had improved DFS [HR (95% CI): 51.3 (2.85–922), p = 0.008, and 17.9 (1.05–306), p = 0.046, respectively]. The 5-year OS and DFS rates were respectively 61.2% and 74.6% in high LC3 expression patients and 0% and 0% in those with low LC3 expression. Conclusion: High LC3 expression in tumors is significantly associated with mild clinicopathological characteristics and favorable clinical prognosis in patients with cHCC-CC after resection.
Virtual intracranial electroencephalography for epilepsy surgery using ictal magnetoencephalography
Authors: Cao Miao , Galvis Daniel , Vogrin Simon , Woods William , Vogrin Sara , Wang Fan , Woldman Wessel , Terry John , Peterson Andre , Plummer Chris , Cook Mark
Published: February 2021

Modelling the interactions that arise from neural dynamics in seizure genesis is challenging but important in the effort to improve the success of epilepsy surgery. Dynamical network models developed from physiological evidence offer insights into rapidly evolving brain networks in the epileptic seizure. A major limitation of previous studies in this field is the dependence on invasive cortical recordings with constrained spatial sampling of brain regions that might be involved in seizure dynamics. Here, we propose a novel approach, virtual intracranial electroencephalography (ViEEG), that combines non-invasive ictal magnetoencephalographic imaging (MEG), dynamical network models and a virtual resection technique. In this proof-of-concept study, we show that ViEEG signals reconstructed from MEG alone preserve critical temporospatial characteristics for dynamical approaches to identify brain areas involved in seizure generation. Our findings demonstrate the advantages of non-invasive ViEEG over the current presurgical ‘gold-standard’ – intracranial electroencephalography (iEEG). Our approach promises to optimise the surgical strategy for patients with complex refractory focal epilepsy.
Mid Upper Arm Circumference in Pregnant Women and Birth Weight in Newborns as Substitute for Skinfold Thickness: Findings from the MAASTHI Cohort Study, India.
Authors: Babu Giridhara R. , Das Aritra , Lobo Eunice , R. Deepa , John Daisy A. , Thankachan Prashanth , Khetrapal Sonalini , Benjamin-Neelon Sara E. , Murthy GVS
Published: February 2021

Background: Estimating fat deposition in public hospitals using gold-standard measurements such as high-resolution imaging is unaffordable and it is challenging to use skinfold thickness. We aimed to identify the appropriate substitute marker for skinfold thickness to estimate fat deposition in pregnant women and infants.Methods: The study is part of a prospective cohort study titled, MAASTHI in Bengaluru, from 2016-19. Anthropometric measurements such as body weight, head circumference, mid upper arm circumference (MUAC), and skinfold thickness were measured in pregnant women between 14 to 36 weeks of gestational age; while measurements such as birth weight, head, chest, waist, hip, mid upper arm circumference, and skinfold thickness were recorded for newborns. We calculated Kappa statistics to assess agreement between these anthropometric markers with skinfold thickness. Results: We found the highest amount of agreement between total skinfold thickness and MUAC (Kappa statistic, 0.42; 95% CI 0.38-0.46) in pregnant women. For newborns, the highest agreement with total skinfold thickness was with birth weight (0.57; 95% CI 0.52-0.60). Our results indicate that MUAC higher than 29.2 cm can serve as a suitable alternative to total skinfolds-based assessments for obesity screening in pregnancy in public facilities. Similarly, a birth weight cut-off of 3.45 kg can be considered for classifying obesity among the newborns. Conclusions: Mid upper arm circumference and birth weight can be used as markers of skinfold thickness, reflecting fat deposition in pregnant women and the infant, respectively. These two anthropometric measurements could substitute for skinfold thickness in low- and middle-income urban India settings.
A Self-contained and Self-explanatory DNA Storage System
Authors: Li Min , Dai Junbiao , Jiang Qingshan , Wang Yang
Published: February 2021

Current research on DNA storage usually focuses on the improvement of storage density with reduced gene synthesis cost by developing effective encoding and decoding schemes while lacking the consideration on the uncertainty in ultra long-term data storage and retention. Consequently, the current DNA storage systems are often not self-containment, implying that they have to resort to external tools for the restoration of the stored gene data. This may result in high risks in data loss since the required tools might not be available due to the high uncertainty in far future. To address this issue, we propose in this paper a self-contained DNA storage system that can make self-explanatory to its stored data without relying on any external tools. To this end, we design a specific DNA file format whereby a separate storage scheme is developed to reduce the data redundancy while an effective indexing is designed for random read operations to the stored data file. We verified through experimental data that the proposed self-contained and self-explanatory method can not only get rid of the reliance on external tools for data restoration but also minimize the data redundancy brought about when the amount of data to be stored reaches a certain scale.