bluuebunny/crossref_metadata_2025 huggingface dataset:
A GIS-Based Spatiotemporal Analysis of the Relationship between the Outbreak of COVID-19, Delta Variant and Construction in Sydney and Melbourne
Authors: Smith Kai Ilie , Shirowzhan Sara
Published: December 2022

The outbreak of the Delta Variant of COVID-19 presents a natural experiment without modern precedent. As authorities scrambled to control the spread of the disease in Australia’s largest cities, construction workers were allowed to keep working on site without the benefit of mandatory vaccination, unlike their peers in healthcare, defense, education or aviation. Using publicly available COVID-19 surveillance data, we analyzed the geographic spread of the Delta Variant and its relationship with construction in both cities. The period of this study covers the identification of the first case of community transmission to the achievement of 90% full vaccination in the eligible population. We show how the risk profile of construction workers varies according to socio-economic status such that Machinery Operators and Drivers were most at risk, followed by Laborers, owing to where they tend to live in each city. Moreover, these highly mobile workers may unknowingly serve as vectors for the spread of infectious disease to the most vulnerable communities in an urban setting. Remarkably, we also found that the risk profile of construction businesses can also be described similarly in terms of annual income. Sole traders and small businesses were mostly located in vulnerable areas, which presents threats to business continuity that public policy must address. We observed that the first eight weeks of an outbreak are critical; after this time, vulnerable workers and most construction businesses will see steep rises in their exposure to the risk of infection until the disease is brought under control. Accordingly, we recommend short, sharp pauses of all construction works on site to control the spread of future pandemic outbreaks once cases of community transmission are detected. Fiscal policy must support workers and small business owners, so they are not forced to choose between their health and earning a living during these periods. The government and trade unions must commit to mandatory vaccination for construction workers to safeguard their communities. Health authorities must continuously engage with particularly vulnerable workers as immunity wanes and vaccine boosters become necessary. Digital disinformation must be tirelessly countered by consistent expert medical advice at all levels of the industry.
User-Generated Content in Social Media: A Twenty-Year Bibliometric Analysis in Hospitality
Authors: Kitsios Fotis , Mitsopoulou Eleftheria , Moustaka Eleni , Kamariotou Maria
Published: December 2022

This article aims to present a bibliometric analysis regarding social media platforms and User-Generated Content (UGC) in hospitality. One hundred fifty-one peer-reviewed articles were analyzed using Webster’s and Watson’s (2002) methodology, a concept-driven methodology that helps analyze different concepts and contexts of a research field. Articles classified into five areas and a bibliometric analysis were presented to discuss the publication year, journals and publishers, authors, number of citations, research method implemented, social networking and users’ perceived value, user-generated content and travel planning, e-Word-of-Mouth (e-WOM) and brand image building, and hotel performance. The findings of this study showed that the number of studies in this field has increased over the last decade. However, exploration of the subject needs to be promoted (particularly experimental) because research in hospitality social media is still in the early phases on the grounds that publications concentrate on explicit subjects, regions, and sources of publication.
A Survey on Computer-Aided Intelligent Methods to Identify and Classify Skin Cancer
Authors: Jeyakumar Jacinth Poornima , Jude Anitha , Priya Asha Gnana , Hemanth Jude
Published: December 2022

Melanoma is one of the skin cancer types that is more dangerous to human society. It easily spreads to other parts of the human body. An early diagnosis is necessary for a higher survival rate. Computer-aided diagnosis (CAD) is suitable for providing precise findings before the critical stage. The computer-aided diagnostic process includes preprocessing, segmentation, feature extraction, and classification. This study discusses the advantages and disadvantages of various computer-aided algorithms. It also discusses the current approaches, problems, and various types of datasets for skin images. Information about possible future works is also highlighted in this paper. The inferences derived from this survey will be useful for researchers carrying out research in skin cancer image analysis.
Virtual Reality Applications Market Analysis—On the Example of Steam Digital Platform
Authors: Stecuła Kinga
Published: December 2022

This paper presents research on the topic of virtual reality (VR) applications. It conducts a quantitative analysis of virtual reality applications available in the international market using the example of a digital platform, which was the Steam platform. The study presents and analyzes data on the number of applications in the selected categories, such as genres, types of headsets, and language. The research also includes the analysis of the top-rated VR applications, their reviews, and their features, recognized based on the tags describing them. Additionally, the article provides and systematizes new knowledge about the VR applications environment. Based on the results, it was concluded that the most numerous group of VR applications was action applications, and they account for more than half of all VR apps (51.22%). Following this, there were casual games (40.78%) and then simulation VR apps (37.35%). Referring to the results of the top-rated VR applications (‘overwhelmingly positive’ status on Steam), there were only two apps with a result of 98% (the highest rated) positive feedback: Half-Life: Alyx, the action and adventure app, which is a shooter described as zombie horror, and Walkabout Mini Golf VR, a casual and minimalist sport application. When it comes to the analysis of the tags of the top-rated VR applications, the most repeated tags, despite the ‘VR’ tag, included ‘first-person’ and ‘singleplayer’ (occurred in the descriptions of 68% of the applications).
A One-Dimensional Cu(I) Coordination Polymer with Optical Sensing of Oxygen and Temperature
Authors: Chen Wan-Tao , Li Chen-Hui , Zhou Wan-Qing , Huang Jing-Tao , Ye Jia-Wen , Chen Ling
Published: December 2022

Due to their tight structures, it is usually difficult for one-dimensional (1D) coordination polymers (CPs) to form permanent pores unless 2D and 3D topologies are formed via supramolecular interactions, so studies in the field of oxygen sensing on 1D CPs are rarely reported. Here, we report a 1D Cu(I) cluster-based CP with dual sensing characteristics for temperature and oxygen. Even if the porosity is only 6.6%, the quenching rate of this CP reaches 98.4% with 1 bar O2 at room temperature. Its luminescence intensity exhibits a unique thermal “quenching, then activating” behavior during monotonic variations in temperature.
Generalized Peukert Equation with Due Account of Temperature for Estimating the Remaining Capacity of Nickel–Metal Hydride Batteries
Authors: Yazvinskaya Nataliya N.
Published: December 2022

In this paper, it is experimentally proven that the generalized Peukert equation C(i,T) = Cm(T)/(1 + (i/i0(T))n(T)) is applicable to nickel–metal hydride batteries at any discharge currents, while the classical Peukert equation can be used only in a limited range of the discharge currents (approximately from 0.3 Cn to 3 Cn). In addition, the classical Peikert equation does not take into account the influence of the temperature of a battery on its released capacity. It is also proven that for the nickel–metal hydride batteries, the generalized Peukert equation heavily depends on battery temperature (via the parameters Cm(T), i0(T) and n(T)). The temperature dependencies of the parameters of the generalized Peukert equation and their physical meaning are also established. The obtained generalized Peukert equation, which considers the batteries’ temperature, can be used at any discharge current and temperature of the batteries.
Characterization of Two Aldehyde Oxidases from the Greater Wax Moth, Galleria mellonella Linnaeus. (Lepidoptera: Pyralidae) with Potential Role as Odorant-Degrading Enzymes
Authors: Godoy Ricardo , Arias Ignacio , Venthur Herbert , Quiroz Andrés , Mutis Ana
Published: December 2022

Odorant-degrading enzymes (ODEs) are proposed to degrade/inactivate volatile organic compounds (VOCs) on a millisecond timescale. Thus, ODEs play an important role in the insect olfactory system as a reset mechanism. The inhibition of these enzymes could incapacitate the olfactory system and, consequently, disrupt chemical communication, promoting and complementing the integrated pest management strategies. Here, we report two novel aldehyde oxidases, AOX-encoding genes GmelAOX2 and GmelAOX3, though transcriptomic analysis in the greater wax moth, Galleria mellonella. GmelAOX2 was clustered in a clade with ODE function, according to phylogenetic analysis. Likewise, to unravel the profile of volatiles that G. mellonella might face besides the sex pheromone blend, VOCs were trapped from honeycombs and the identification was made by gas chromatography–mass spectrometry. Semi-quantitative RT-PCR showed that GmelAXO2 has a sex-biased expression, and qRT-PCR indicated that both GmelAOX2 and GmelAOX3 have a higher relative expression in male antennae rather than female antennae. A functional assay revealed that antennal extracts had the strongest enzymatic activity against undecanal (4-fold) compared to benzaldehyde (control). Our data suggest that these enzymes have a crucial role in metabolizing sex pheromone compounds as well as plant-derived aldehydes, which are related to honeycombs and the life cycle of G. mellonella.
Early Obliterated Cabrol Shunt: Culprit of Aortopulmonary Fistula in Large Pseudoaneurysm after Bentall Procedure
Authors: Zhang Bowen , Liu Yanxiang , Dun Yaojun , Sun Xiaogang
Published: December 2022

Aortopulmonary fistula secondary to a large pseudoaneurysm after a Bentall procedure is a rare but complex complication. Herein, we report a case of Cabrol shunt obliteration and pseudoaneurysm formation three months after a Bentall procedure. The patient also presented with congestive heart failure due to an aortopulmonary fistula six years later. Surgery was successfully performed to repair the dehiscence of the biliteral coronary ostia and the aortopulmonary fistula, and to replace the ascending aorta. Postoperatively, the patient recovered uneventfully.
Cardiac Biomarkers in Sports Cardiology
Authors: Costache Alexandru-Dan , Leon-Constantin Maria-Magdalena , Roca Mihai , Maștaleru Alexandra , Anghel Răzvan-Constantin , Zota Ioana-Mădălina , Drugescu Andrei , Costache Irina-Iuliana , Chetran Adriana , Moisă Ștefana-Maria , Huzum Bogdan , Mitu Ovidiu , Cumpăt Carmen , Honceriu Cezar , Mitu Florin
Published: December 2022

Sustained physical activity induces morphological and functional changes in the cardiovascular system. While mostly physiological, they can also become a trigger for major adverse cardiovascular events, the most severe of which are sudden cardiac arrest and sudden cardiac death. Therefore, any novel method which can help more accurately estimate the cardiovascular risk should be considered for further studying and future implementation in the standard protocols. The study of biomarkers is gaining more and more ground as they have already established their utility in diagnosing ischemic cardiac disease or in evaluating cardiac dysfunction in patients with heart failure. Nowadays, they are being implemented in the screening of apparently healthy individuals for the assessment of the cardiovascular risk. The aim of this paper is to gather published data regarding the measurements of cardiac biomarkers in athletes, i.e., troponins, myoglobin, CK-MB, NT-proBNP, and D-Dimers, and their potential use in the field of sports cardiology.
Bone Modeling after Orthodontic Extrusion: A Histomorphometric Pilot Study
Authors: Montevecchi Marco , Marucci Gianluca , Pignataro Barbara , Piana Gabriela , Alessandri-Bonetti Giulio , Checchi Vittorio
Published: December 2022

During osteogenesis and bone modeling, high vascularity and osteoblastic/osteoclastic cell activity have been detected. A decrease in this activity is a sign of complete bone formation and maturation. Alveolar bone maturation seems to occur within weeks and months; however, the precise timing of the alveolar bone modeling is still unknown. The aim of this clinical pilot study was to investigate the bone modeling of neo-apposed tissue during orthodontic extrusive movements, through a histomorphometric analysis of human biopsies. This study was conducted on third mandibular molars sockets, and all teeth were extracted after orthodontic extrusion between 2010 and 2014. After different stabilization timings, extractions were performed, and a specimen of neo-deposed bone was harvested from each socket for the histomorphometric analysis. Histological parameters were evaluated to identify bone quantity and quality. This study included 12 teeth extracted from 9 patients. All specimens were composed of bone tissue. Bone samples taken after 1 and 1.5 months of stabilization presented remarkable percentages of woven bone, while after 2 months, a relevant decrease was observed. Histomorphometric analysis suggested that after orthodontic extrusion, a period of stabilization of 2 months allows the neo-deposed bone to mature.
Association between Genotype, Presentation, and Outcome in Childhood Idiopathic and Hereditary Pulmonary Arterial Hypertension
Authors: Xu Zhuoyuan , Zhang Hongsheng , Zhang Chen , Li Qiangqiang , Gu Hong
Published: December 2022

Background: Paediatric-onset idiopathic/hereditary pulmonary arterial hypertension (IPAH/HPAH) is partially linked to genetic factors that may also affect treatment response and outcome. The relation between clinical characteristics and pathogenicity of gene variants in childhood IPAH/HPAH is still not well understood. Methods: We retrospectively analyzed IPAH/HPAH paediatric patients aged between 3 months and 18 years under follow-up at a large tertiary referral center. Whole-exome sequencing focused on PAH high-risk genes was performed in all patients. Pathogenicity grading of gene variant sites was assessed using ClinVar and population frequencies. The association between gene variants and death was studied using Cox proportional multivariate models. Results: Overall, 129 patients (54.3% females; 91.5% on PAH therapy) with a median age at diagnosis of 6.8 (IQR 3.4–10.7) years were included. A relevant PAH gene variant was detected in 95 patients (73.6%). The most common variants were in the BMPR2 (n = 43, 3%) gene. Over a median follow-up period of 27.6 months, 26 children died. The presence of a likely pathogenic genetic variant was significantly associated with survival (HR: 3.56, p = 0.005) on multivariable Cox analysis. The number of PAH-specific drugs at presentation was associated with better survival in the cohort with pathogenic variants (p = 0.02). Conclusions: Pathogenic/likely pathogenic genetic variants are prevalent in children with PAH and are related to a worse prognosis irrespective of other recognized risk factors in this population. Combination PAH therapy was associated with superior prognosis in children with pathogenic variants or BMPR2 variants. Therefore, proactive medical therapy should be employed in this population.
Characteristics of Sleep Disturbance in Patients with Long COVID: A Retrospective Observational Study in Japan
Authors: Sunada Naruhiko , Nakano Yasuhiro , Otsuka Yuki , Tokumasu Kazuki , Honda Hiroyuki , Sakurada Yasue , Matsuda Yui , Hasegawa Toru , Omura Daisuke , Ochi Kanako , Hagiya Hideharu , Ueda Keigo , Kataoka Hitomi , Otsuka Fumio
Published: December 2022

Objectives: The objective of this study was to determine the clinical and endocrinological features of sleep disturbance in patients with long COVID. Methods: This study was a single-center retrospective observational study for patients who visited the COVID-19 aftercare outpatient clinic (CAC) established in Okayama University Hospital in Japan during the period from 15 February 2021 to 29 July 2022. The long COVID patients were divided into two groups based on the presence or absence of sleep disturbance, and the clinical and laboratory characteristics of the patients were analyzed. Results: Out of 363 patients with long COVID, after excluding 6 patients, 60 patients (16.5%) (55% males, median age of 38 years) complaining of sleep disturbance were compared with 303 patients (83.5%) (43% males, median age of 40 years) without sleep-related symptoms. Although there were no significant differences in clinical backgrounds and severities of COVID-19 between the two groups by the multivariate analysis, the percentage of long COVID patients with sleep disturbance was significantly increased among patients infected in the Omicron-dominant phase. In addition, the prevalence rate of sleep disturbance in patients when infected in the Omicron phase (24.8%) was two-times higher than that in patients infected in the Delta phase (12.8%). Of note, the percentages of patients with sleep disturbance who also complained of general fatigue, headache, concentration loss, anxiety, low-grade fever, and brain fog symptoms were higher than the percentages of patients without sleep disturbance who had the same complaints. Among the types of sleep disturbance, the percentage of patients who complained of loss of sleep induction (75%) was much higher than the percentage of patients with early-awakening sleep disturbance (6.7%), and many of the patients with mid-awakening types of insomnia had brain fog symptoms. Endocrine examinations revealed that long COVID patients with sleep disturbance had significantly higher levels of plasma adrenocorticotropin and lower levels of serum growth hormone, suggesting the presence of hypothalamic–pituitary stress. Conclusion: The prevalence of sleep disturbance has been increasing in long COVID patients infected in the Omicron phase with a certain clinical and endocrine trend.
Class II Malocclusion in Adult Patients: What Are the Effects of the Intermaxillary Elastics with Clear Aligners? A Retrospective Single Center One-Group Longitudinal Study
Authors: Rongo Roberto , Dianišková Simona , Spiezia Antonio , Bucci Rosaria , Michelotti Ambrosina , D’Antò Vincenzo
Published: December 2022

Aim: To evaluate the dental effects of the treatment with clear aligners and intermaxillary elastics in adult patients with Class II malocclusion. Material and methods: A sample of 20 Class II patients treated with Invisalign aligners (5 M and 15 F; mean age of 27.6 ± 6.3 years) was included in this single-center one-group longitudinal study. Dental cast and cephalometric records were analyzed before (T0) and after treatment (T1). Data were analyzed with a t-test for paired data (p < 0.05). Results: There was a significant reduction of the Overjet (OVJ= −1.4 ± 0.2; p ≤0.001) and a retroposition of upper incisors (U1-NPo = −1.3 ± 1.7; p < 0.001). Furthermore, distalization of upper molars with an improvement of molar class (U6-PT Vertical = −0.93 ± 0.97; p < 0.001; Molar Relation = −0.75 ± 0.45; p < 0.001) was observed. A good control of the lower and upper incisor inclination was present, highlighted by the non-significant changes in these values (L1-GoGn = −0.12 ± 5.4; p = 0.923; U1-AnsPns = −1.1 ± 8.1; p = 0.551). In the lower arch, an increase in the intermolar diameter (0.6 ± 1.0; p = 0.01) was present. Finally, there were no statistically significant changes in all the skeletal variables (ANPg = 0.005 ± 0.687; p = 0.974; SN/MP = −0.47 ± 1.9; p = 0.298). Conclusions: Treatment with Invisalign aligners shows a reduction of the Overjet, a retroposition of the upper incisors, good control of the lower incisors, and an improvement of the molar relationship.
Role of Branched-Chain Amino Acids and Their Derivative β-Hydroxy-β-Methylbutyrate in Liver Cirrhosis
Authors: Espina Silvia , Sanz-Paris Alejandro , Bernal-Monterde Vanesa , Casas-Deza Diego , Arbonés-Mainar Jose Miguel
Published: December 2022

Branched-chain amino acids (BCAA) supplementation is used to promote protein synthesis in different clinical conditions in which proteolysis is increased. In addition, lower plasma BCAA levels have been related to an increased risk of hepatic encephalopathy in liver cirrhosis. In this article we will review the role of supplementation with BCAAs and BCAA derivative β-hydroxy-β-methylbutyrate (HMB) in liver cirrhosis, focusing on nutritional and clinical effects. Evidence shows that BCAA supplementation slightly increases muscle mass and body mass index, with an upward trend in muscular strength and no change in fat mass. Moreover, BCAA supplementation improves symptoms of hepatic encephalopathy, and is indicated as second-line therapy. The evidence is more limited for BCAA derivatives. HMB supplementation appears to increase muscle mass in chronic diseases associated with cachexia, although this effect has not yet been clearly demonstrated in liver cirrhosis studies. To date, HMB supplementation has no clinical indication in liver cirrhosis.
The Course of COVID-19 in Patients with Systemic Autoimmune Rheumatic Diseases
Authors: Rorat Marta , Zarębska-Michaluk Dorota , Kowalska Justyna , Kujawa Krzysztof , Rogalska Magdalena , Kozielewicz Dorota , Lorenc Beata , Sikorska Katarzyna , Czupryna Piotr , Bolewska Beata , Maciukajć Jadwiga , Piekoś Tomasz , Podlasin Regina , Dworzańska Anna , Mazur Włodzimierz , Brzdęk Michał , Szymanek-Pasternak Anna , Flisiak Robert
Published: December 2022

Patients with systemic autoimmune rheumatic disease (SARD) have increased susceptibility to viral infections, including SARS-CoV-2. The aim of this study was to analyse the SARD patient population with COVID-19 (coronavirus disease 2019) in terms of baseline characteristics, severity, course and outcomes of the disease compared with the non-SARD group, and to identify factors associated with prognosis, including remdesivir therapy efficacy. Retrospective study comprised 8220 COVID-19 cases from the SARSTer database, including 185 with SARD. Length of hospitalisation, duration of oxygen therapy, mortality and the need for HFNO (high-flow nasal oxygen) and/or NIV (noninvasive ventilation) were significantly higher in the SARD versus non-SARD group. There was no difference in clinical features on admission to hospital. Patients with SARD were older and more likely to have cardiovascular, pulmonary and chronic kidney diseases. Age, the presence of cardiovascular disease, more severe conditions on admission and higher inflammatory marker values were found to be risk factors for death in the SARD group. In patients with SARD treated with remdesivir, there was a trend towards improved mortality but without statistical significance. Length of hospitalisation, 28-day mortality and the need for HFNO and/or NIV were higher in the SARD group. These patients often had other chronic diseases and were older.
Impact of Urinary Incontinence on Physical Function and Respiratory Muscle Strength in Incontinent Women: A Comparative Study between Urinary Incontinent and Apparently Healthy Women
Authors: Abidi Sirine , Ghram Amine , Ghroubi Sameh , Ahmaidi Said , Elleuch Mohamed Habib , Girard Olivier , Papasavvas Theodoros , Laukkanen Jari , Ben Saad Helmi , Knechtle Beat , Weiss Katja , Chlif Mehdi
Published: December 2022

Patients with stress urinary incontinence (SUI) may be afraid to increase intra-abdominal pressure to avoid incontinence. This could lead to weak expiratory muscles. The aim of this study was to investigate the association between respiratory muscle strength, physical function, and SUI in patients with SUI. A cross-sectional study was conducted in the Physical Medicine and Functional Rehabilitation Department. Thirty-one incontinent women (IG) and twenty-nine women in a control group (CG) were enrolled in this study. Anthropometric data, respiratory muscle strength (maximal inspiratory pressure; maximal expiratory pressure), SUI (Urogenital Distress Inventory-6; Incontinence Impact Questionnaire-7; Pad test), and physical function (waist circumference; timed-up-and-go test; abdominal muscle strength) were assessed. Body fat, body mass index, body weight, and waist circumference were higher in IG than CG (p < 0.01), while postural gait and abdominal muscles were lower (p < 0.001). Respiratory muscle strength displayed moderate correlations with SUI severity, especially for maximal expiratory pressure (p < 0.01). Maximal expiratory pressure was moderately associated with physical function. Deterioration in respiratory muscle strength is a characteristic of women with SUI. In this population, pelvic floor muscle training may be prescribed to improve continence. By feeling more confident about increasing intra-abdominal pressure, women with SUI would strengthen their expiratory muscles and eventually improve their physical function.
Approach to Radical Hysterectomy for Cervical Cancer in Pregnancy: Surgical Pathway and Ethical Considerations
Authors: Guerrisi Rocco , Smyth Sarah , Ismail Lamiese , Horne Amanda , Ferrari Federico , Soleymani majd Hooman
Published: December 2022

Introduction. Cervical cancer is currently the fourth most common cancer in women and in the poorest countries this neoplasia still represents a widespread and potentially lethal disease. We present a rare case of cervical cancer in pregnancy, analyzing the historical changes behind the procedure of radical hysterectomy for cervical cancer and discussing variations in surgical techniques and anatomical definitions that have since been proposed. Results. We present the case of a 33-year-old patient who attended with vaginal bleeding in the second trimester of pregnancy. Examination revealed an abnormal looking cervix, with investigations concluding stage IIb squamous cell carcinoma. Following extensive discussion regarding management options, the patient went on to have a peripartum foetocidal type III nerve sparing radical Wertheim hysterectomy at 18 weeks gestation with conservation and transposition of the ovaries above the level of the pelvic brim. The patient recovered well without significant morbidity and received further input from fertility and psychological medical teams in addition to adjuvant treatment within the department of clinical oncology. Discussion. This case represents several elements of great interest and learning. Notably, we highlight this both due to the surgical challenges that a gravid uterus presents in the execution of a radical hysterectomy; and regarding the compassionate care demonstrated by the team - not only in supporting the patient and her partner in a period of profound turmoil in terms of the management of their cancer diagnosis and unborn child, but also regarding the uncertainty in consideration of the oncological and fertility related outcomes. Conclusion. This manuscript adds to the growing literature on the appropriate use of radical surgery for cervical cancer, more specifically during pregnancy and in consideration of such ethical dilemma, where management guidelines do not exist to aid clinicians further in their provision of treatment.
Factors Associated with Early Discharge after Thoracoscopic Lobectomy: Results from the Italian VATS Group Registry
Authors: Maniscalco Pio , Tamburini Nicola , Fabbri Nicolò , Quarantotto Francesco , Rizzardi Giovanna , Amore Dario , Lopez Camillo , Crisci Roberto , Spaggiari Lorenzo , Valpiani Giorgia , Bertolaccini Luca , Cavallesco Giorgio , on behalf of the VATS Group
Published: December 2022

Objective. There are limited data for estimating the risk of early discharge following thoracoscopic lobectomy. The objective was to identify the factors associated with a short length of stay and verify the influence of these variables in uncomplicated patients. Methods. We reviewed all lobectomies reported to the Italian VATS Group between January 2014 and January 2020. Patients and perioperative characteristics were divided into two subgroups based on whether or not they met the target duration of stay (≤ or >4 days). The association between preoperative and intraoperative variables and postoperative length of stay (LOS) ≤4 days was assessed using a stepwise multivariable logistic regression analysis to identify factors independently associated with LOS and factors related to LOS in uncomplicated cases. Results. Among 10,240 cases who underwent thoracoscopic lobectomy, 37.6% had a hospital stay ≤4 days. Variables associated with LOS included age, hospital surgical volume, Diffusion Lung CO % (81 [69–94] vs. 85 [73–98]), Forced Expiratory Volume (FEV1) % (92 [79–106] vs. 96 [82–109]), operative time (180 [141–230] vs. 160 [125–195]), uniportal approach (571 [9%] vs. 713 [18.5%]), bioenergy sealer use, and pain control through intercostal block or opioids (p < 0.001). Except for FEV1 and blood loss, all other factors emerged significantly associated with LOS when the analysis was limited to uncomplicated patients. Conclusions. Demographic, clinical, and surgical variables are associated with early discharge after thoracoscopic lobectomy. This study indicates that these characteristics are associated with early discharge. This result can be used in association with clinical judgment to identify appropriate patients for fast-track protocols.
Contrast-Enhanced Ultrasound in the Differentiation between the Most Common Benign Parotid Gland Tumors: A Systematic Review and Meta-Analysis
Authors: Rogalska Marta , Antkowiak Lukasz , Kasperczuk Anna , Scierski Wojciech
Published: December 2022

Recently, contrast-enhanced ultrasound (CEUS) has become a promising tool in distinguishing benign from malignant parotid gland tumors. However, its usefulness in differentiating various benign parotid tumors has not been determined so far. This study aimed to systematically review the literature to determine the utility of CEUS in the preoperative differentiation between pleomorphic adenomas (PAs) and Warthin’s tumors (WTs) of the parotid gland. PubMed, Embase, and Cochrane were searched for English-language articles published until 21 July 2022. Fifteen studies were included. On CEUS examination, a significantly greater percentage of PAs displayed heterogeneous enhancement texture compared to WTs. Contrarily, the enhanced lesion size, the enhancement margin, and the presence of the enhancement rim did not differ significantly between the entities. Significantly longer normalized mean transit time (nMTT) and time to peak (TTP) were observed in PAs. Contrarily, the mean values of area under the curve (AUC) and time from peak to one half (TPH) were significantly higher for WTs. Due to the considerable overlap among the qualitative CEUS characteristics of PAs and WTs, the reproducible, investigator-independent quantitative CEUS measurements have a greater potential to distinguish PAs from WTs, which might influence the selection of an appropriate management strategy.
Three-Dimensional Automated, Machine-Learning-Based Left Heart Chamber Metrics: Associations with Prevalent Vascular Risk Factors and Cardiovascular Diseases
Authors: Barbieri Andrea , Albini Alessandro , Chiusolo Simona , Forzati Nicola , Laus Vera , Maisano Anna , Muto Federico , Passiatore Matteo , Stuani Marco , Torlai Triglia Laura , Vitolo Marco , Ziveri Valentina , Boriani Giuseppe
Published: December 2022

Background. Three-dimensional transthoracic echocardiography (3DE) powered by artificial intelligence provides accurate left chamber quantification in good accordance with cardiac magnetic resonance and has the potential to revolutionize our clinical practice. Aims. To evaluate the association and the independent value of dynamic heart model (DHM)-derived left atrial (LA) and left ventricular (LV) metrics with prevalent vascular risk factors (VRFs) and cardiovascular diseases (CVDs) in a large, unselected population. Materials and Methods. We estimated the association of DHM metrics with VRFs (hypertension, diabetes) and CVDs (atrial fibrillation, stroke, ischemic heart disease, cardiomyopathies, >moderate valvular heart disease/prosthesis), stratified by prevalent disease status: participants without VRFs or CVDs (healthy), with at least one VRFs but without CVDs, and with at least one CVDs. Results. We retrospectively included 1069 subjects (median age 62 [IQR 49–74]; 50.6% women). When comparing VRFs with the healthy, significant difference in maximum and minimum indexed atrial volume (LAVi max and LAVi min), left atrial ejection fraction (LAEF), left ventricular mass/left ventricular end-diastolic volume ratio, and left ventricular global function index (LVGFI) were recorded (p < 0.05). In the adjusted logistic regression, LAVi min, LAEF, LV ejection fraction, and LVGFI showed the most robust association (OR 3.03 [95% CI 2.48–3.70], 0.45 [95% CI 0.39–0.51], 0.28 [95% CI 0.22–0.35], and 0.22 [95% CI 0.16–0.28], respectively, with CVDs. Conclusions. The present data suggested that novel 3DE left heart chamber metrics by DHM such as LAEF, LAVi min, and LVGFI can refine our echocardiographic disease discrimination capacity.
Availability of Readable Online Spanish Rhinosinusitis Outcome Measures
Authors: Lee Saangyoung E. , Farzal Zainab , Kimple Adam J. , Moreno-Luna Ramón , Senior Brent A. , Thorp Brian D. , Ebert Charles S.
Published: December 2022

Background: Patient-reported outcome measures (PROMs) are useful instruments that give providers insight into patients’ experiences with disease by quantifying the symptoms that matter most to patients. Results of these questionnaires can help guide management in chronic rhinosinusitis. However, these tools are often developed for native English speakers, which disadvantages others, who already have a language barrier to care. The aim of this study is to evaluate accessibility and readability of Spanish PROMs used to evaluate rhinosinusitis. Methods: Three Spanish readability measures, Gilliam, Peña & Mountain; SOL; and Fernandez-Huerta were used to evaluate PROMs utilized for rhinosinusitis. PROMs with sixth-grade readability level or easier were considered to meet health literacy recommendations. Results: Four Spanish PROMs utilized in assessment of rhinosinusitis were identified and evaluated. Cuestionario Español de Calidad de Vida en Rinitis (ESPRINT-15) was the most readable PROM and met readability recommendations in two of three measures. Nasal Obstruction Symptom Evaluation met suggested levels in one measure. The remainder of readability scores were more difficult than recommended. Conclusion: PROMs are powerful clinical tools that help patients communicate their symptoms and self-advocate. For providers to gain accurate and useful information, these measures should be written at appropriate readability levels. Most Spanish PROMs used for assessment of rhinosinusitis were above recommended readability. Development of future PROMs should ensure appropriate readability levels to provide good patient-centered care for our primarily Spanish speaking patients.
Risk Factors and Outcomes of Extended Length of Stay in Older Adults with Intertrochanteric Fracture Surgery: A Retrospective Cohort Study of 2132 Patients
Authors: Long Yubin , Wang Tao , Xu Xin , Ran Guangyuan , Zhang Heng , Dong Qi , Zhang Qi , Guo Junfei , Hou Zhiyong
Published: December 2022

We aimed to identify the risk factors associated with an extended length of hospital stay (eLOS) in older hip-fracture patients and to explore the relationships between eLOS and mortality and functional outcomes. In this retrospective analysis of surgically treated intertrochanteric fracture (IF) patients, all variables were obtained and compared between the eLOS group and the normal LOS group. All participants were followed-up for a minimum of two years and the relation between the eLOS and all-cause mortality and functional outcomes were compared. After adjustment for potential confounders, we identified that patients with high modified Elixhauser’s Comorbidity Measure (mECM) had the highest likelihood of eLOS, followed by obesity, admission in winter, living in urban, pulmonary complications, admission in autumn, and time from injury to surgery. In addition, our results showed no significant difference in the mortality and functional outcomes between the two groups during follow-up. By identifying these risk factors in the Chinese geriatric population, it may be possible to risk-stratify IF patients and subsequently streamline inpatient resource utilization. However, the differences between health care systems must be taken into consideration. Future studies are needed to preemptively target the modifiable risk factors to demonstrate benefits in diminishing eLOS.
The Assessment of the Socioemotional Disorder in Neurodegenerative Diseases with the Revised Self-Monitoring Scale (RSMS)
Authors: Dimitriou Tatiana , Parthimos Theodore , Kamtsadeli Vasiliki , Tsinia Niki , Hatzopoulou Maria , Lykou Evi , Chatziantoniou Lina , Papatriantafyllou Olga , Tzavara Chara , Zikos Panagiotis , Papageorgiou Sokratis , Miller Bruce , Rankin Kate , Papatriantafyllou John
Published: December 2022

Background: Social cognition helps people to understand their own and others’ behavior and to modulate the way of thinking and acting in different social situations. Rapid and accurate diagnoses of neurodegenerative diseases are essential, as social cognition is affected by these diseases. The Revised Self-Monitoring Scale (RSMS) is a scale that detects social–emotional cognition deficits. Aim: The aim of the current study is to examine how socioemotional parameters are affected by neurodegenerative diseases and whether the RSMS can discern these disorders based on the socioemotional parameters in the Greek population. Methods/Design: A total of 331 dementia subjects were included. Mini Mental State Examination (MMSE) and Addenbrooke’s Cognitive Examination (Revised, ACE-R) measurements were used in order to assess the cognitive deficits. The Neuropsychiatric Inventory (NPI) was used for the evaluation of the neuropsychiatric symptoms. The RSMS and its two subscales was used in order to detect the socioemotional deficits. Results: The RSMS and its two subscales (RSMS_EX and RSMS_SP) can effectively detect neurodegenerative diseases. The RSMS can detect bvFTD in Alzheimer’s Disease (AD), AD in a healthy cohort, behavioral variant Frontotemporal Dementia (bvFTD) in a healthy cohort, bvFTD in Parkinson’s Disease (PD) and Frontotemporal Semantic Dementia (FTD/SD) in a healthy cohort. It is a useful tool in order to detect frontotemporal dementias. RSMS correlated negatively with the NPI questionnaire total and the subcategories of apathy, disinhibition and eating disorders. The RSMS results are associated with the ACE-R score (specifically verbal fluency). Conclusions: The RSMS is a helpful tool in order to identify socioemotional deficits in neurodegenerative dementias. It is also a useful scale that can discern bvFTD and svPPA in AD patients. A worse RSMS score correlates with a worse ACE-R and NPI. It seems to be a useful scale that can reliably measure social behavior in non-reversible neurodegenerative disorders, such as AD, FTD (bvFTD, svPPA), PDD and PD. The results also apply to the Greek population.
Thermomechanical and Pre-Ignition Properties of Multicomponent Poly(Vnylidene Fluoride)/Aluminum Oxide/Single-Walled Carbon Nanotube Hybrid Nanocomposites
Authors: Gooneratne Ruchinda , Iroh Jude O.
Published: December 2022

Poly(vinylidene fluoride), PVDF is a piezoelectric semi-crystalline fluoroplastic that is widely used in the electronics and semiconductor industry for packaging, sensors, and actuators. PVDF nanocomposites containing single-walled carbon nanotubes, SWCNTs and fumed alumina, Al2O3 were prepared in dimethylformamide, and their thermal and dynamic mechanical properties were determined by using thermogravimetric analysis, TGA, differential scanning calorimetry, DSC and dynamic mechanical analysis, DMA. It was observed from differential scanning calorimetry that the matrix’s degree of crystallinity and enthalpy of melting was reduced in the presence of the nanofillers to about 7.1%, compared to the neat PVDF whose degree of crystallinity was determined to be about 51.3%. The melting temperature, Tm obtained by DSC measurements was also reduced from 171.6 °C to 162.7 °C at high SWCNT loadings. The onset degradation temperature was also lowered in the presence of the nanofillers, especially alumina particulates. Dynamic mechanical analysis of the composites showed a significant improvement in the storage modulus of about 18 GPa in the presence of SWCNT. The glass transition temperature, Tg was significantly increased from −42.6 °C to −33.2 °C due to reinforcement with SWCNT. The reinforcement of PVDF with SWCNT and alumina resulted in greater char retention at 600 °C.
First-Principles Calculations of Crystallographic and Electronic Structural Properties of Au-Cu Alloys
Authors: Trong Dung Nguyen , Long Van Cao , Saraç Umut , Quoc Van Duong , Ţălu Ştefan
Published: December 2022

In this research, we have explored the effect of Au:Cu ratio on the crystallographic and electronic structural properties, formation energies, and radial distribution function (RDF) of Au-Cu alloy materials via density functional calculations. The results show that Au-Cu alloy can be formed in any Au:Cu ratio from 3:1 to 1:3 with a similar possibility. The results also reveal that the lattice constants of both Au and Cu are affected by the LDA-PWC pseudo-field, which is in full agreement with the experimental findings. An increase in the concentration of Cu impurity in Au results in a decrement not only in the lattice constants of the crystal system but also in the total energy of the system (Etot). However, an enhancement in the electron density is determined by increasing Cu impurity concentration in Au. The RDF results confirm the contraction of lattice constants and a structural change in Au-Cu from cubic to tetrahedral is found when the Au:Cu ratio is equal to 1:1. These findings revealed in this work are expected to contribute to future studies on electronic materials.
New Self-Clinching Fasteners for Electric Conductive Connections
Authors: Sampaio Rui F. V. , Pragana João P. M. , Clara Ricardo G. , Bragança Ivo M. F. , Silva Carlos M. A. , Martins Paulo A. F.
Published: December 2022

This paper presents new rotational and longitudinal symmetric self-clinching fasteners to fabricate reliable connections in busbars with low electrical resistance for energy distribution systems. Connections consist of form-closed joints that are hidden inside regions where two busbars overlap. The investigation into the fabrication and performance of the new self-clinched joints involved finite element modelling and experimentation to determine the required forces and to evaluate the electric current flow and the electrical resistance at different service temperatures. The original design of the joints that was proposed in a previous work was modified to account for busbar strips of copper and/or aluminum with similar or dissimilar thicknesses, connected by means of self-clinching fasteners made from the same materials of the busbars, instead of steel. The effectiveness of the new self-clinched joints was compared to that of conventional bolted joints that are included in the paper for reference purposes. The results show that rotational symmetric self-clinching fasteners yield lighter fabrication and more compact joints with a similar electrical resistance to that of bolted joints. They also show that longitudinal symmetric self-clinching fasteners aimed at replicating the resistance-seam-welding contact conditions yield a reduction in electrical resistance to values close to that of ideal joints, consisting of two strips in perfect contact and without contaminant or oxide films along their overlapped surfaces.
Revealing the Shamefaced Crab Calappa granulata (Crustacea: Brachyura) from the Adriatic Sea, Northern Basin of the Mediterranean
Authors: Petrić Mirela , Mihaljević Marina , Brčić Jure , Trumbić Željka
Published: December 2022

This study presents the first data on morphometry, length–weight relationship, diet, reproductive biology, epibionts and genetic identity of the shamefaced crab Calappa granulata from the central eastern Adriatic Sea. A total of 92 crabs were collected during 2011, 2014 and 2015, of which 64 were females and 28 were males. Overall, 11 morphometric characteristics were measured. Carapace length of sampled individuals ranged from 48.46 to 76.09 mm, and body weight from 47.06 to 221.39 g. The length–weight relationship showed negative allometry for males and isometric growth for females. Analysis of the stomach content revealed the crab’s preference for crustaceans (20.28%) and cephalopods (10.58%), less for fish (3.4%) and shellfish (0.28%). Size at first sexual maturity (CL50%) of 59.25 and 66.92 mm was estimated for males and females, respectively. Epibiotic serpulid polychaetes were recorded on the crab exoskeleton with an overall prevalence of 29.3%. Analyses of a partial sequence of mtCOI showed high haplotype (Hd = 0.964) and low nucleotide diversity (π = 0.00598). Phylogenetic inference and estimation of population differentiation (FST = 0.013, p = 0.271) with publicly available Mediterranean sequences currently imply one homogenous population unit. To the best of our knowledge, these are the first nucleotide sequences of C. granulata from the Adriatic Sea made publicly available.
Life Cycle Greenhouse Gas Emission Assessment for Using Alternative Marine Fuels: A Very Large Crude Carrier (VLCC) Case Study
Authors: Huang Jinjin , Fan Hongjun , Xu Xiangyang , Liu Zheyu
Published: December 2022

The International Maritime Organization (IMO) has set decarbonisation goals for the shipping industry. As a result, shipowners and operators are preparing to use low- or zero-carbon alternative fuels. The greenhouse gas (GHG) emission performances are fundamental for choosing suitable marine fuels. However, the current regulations adopt tank-to-wake (TTW) emission assessment methods that could misrepresent the total climate impacts of fuels. To better understand the well-to-wake (WTW) GHG emission performances, this work applied the life cycle assessment (LCA) method to a very large crude carrier (VLCC) sailing between the Middle East and China to investigate the emissions. The life cycle GHG emission impacts of using alternative fuels, including liquified natural gas (LNG), methanol, and ammonia, were evaluated and compared with using marine gas oil (MGO). The bunkering site of the VLCC was in Zhoushan port, China. The MGO and LNG were imported from overseas, while methanol and ammonia were produced in China. Four production pathways for methanol and three production pathways for ammonia were examined. The results showed that, compared with MGO, using fossil energy-based methanol and ammonia has no positive effect in terms of annual WTW GHG emissions. The emission reduction effects of fuels ranking from highest to lowest were full solar and battery-based methanol, full solar and battery-based ammonia, and LNG. Because marine ammonia-fuelled engines have not been commercialised, laboratory data were used to evaluate the nitrous oxide (N2O) emissions. The GHG emission reduction potential of ammonia can be exploited more effectively if the N2O emitted from engines is captured and disposed of through after-treatment technologies. This paper discussed three scenarios of N2O emission abatement ratios of 30%, 50%, and 90%. The resulting emission reduction effects showed that using full solar and battery-based ammonia with 90% N2O abatement performs better than using full solar and battery-based methanol. The main innovation of this work is realising the LCA GHG emission assessment for a deep-sea ship.