bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical and Social Characteristics, Quality of Life, Adherence to Therapy of Out-Patients with Schizophrenic Spectrum Disorders: Cross-Sectional Study
Authors: Burygina L. A. , Grigorieva D. D. , Golubev S. A. , Berezantsev A. Yu. , Shumakova E. A.
Published: September 2023

Background: clinical diversity of schizophrenic spectrum disorders determines a variety of long-term management and treatment outcomes of out-patients.

Aim of the study: to analyze the interrelationships of clinical and social characteristics, quality of life and adherence to therapy in patients with schizophrenic spectrum disorders.

Patients and methods: data of 120 patients observed in a neuropsychiatric dispensary with diagnoses of schizophrenic spectrum disorders (F20, F21, F25 according to ICD-10) were studied.

Results: three categories of individuals were identified, taking into account the high degree of intragroup similarity of clinical and social characteristics. Patients of the first group (29%) have a stable-positive characteristics of social adaptation and a high adherence to therapy. They were characterized by a younger age, mainly an attack-like course of the disease with an affective-delusional structure of exacerbations and weakly pronounced personality changes. Significantly more often than patients of other groups, they received therapy with second-generation antipsychotic drugs of prolonged action. Patients of the second group (39%) have the negative dynamic characteristics of social adaptation and a low adherence to therapy. They were characterized by older age, continuous or episodic types of disease course with increasing defect, higher prevalence of moderately and strongly pronounced positive and negative symptoms at the time of remission. Treatment and rehabilitation measures did not give sufficient results, despite the active use of prolonged antipsychotic drugs of the second generation. In this category of patients, there were phenomena of social drift, with the collapse of social ties, loss of work skills. Patients of the third group (32%) were characterized by contradictory characteristics with stable negative characteristics of social adaptation and high adherence to therapy. A significant part of the patients had negative personality changes and often a low-grade course of the disease with a predominance of neurosis-like and depressive symptoms. Receiving for many years mainly therapy with firstgeneration antipsychotics (APP1) and practically not hospitalized in a psychiatric hospital, they found pronounced social isolation, loneliness and feelings of hostility of the surrounding world.

Conclusions: the management of out-patients with schizophrenic spectrum disorders represent clinical problems depending of different forms of social adaptation and adherence to therapy, for the effective solution of which it is necessary to optimize complex social rehabilitation measures.
Attention Deficit Hyperactivity Disorder: Advanced Possibilities of Diagnostics and Therapy
Authors: Useinova A. N. , Egorova E. A. , Maryanenko S. P.
Published: September 2023

Background: attention deficit hyperactivity disorder (ADHD) is one of the urgent problems of psychoneurology. ADHD has a significant impact on the quality of life of a patient of any age. The variability of clinical manifestations depending on the age of the patient remain the subject of scientific discussion.

The aim of the review: based on the scientific data of recent years, to study achievements in the field of diagnosis and rational choice of drugs used for the purpose of pharmacotherapy of patients of various age categories with ADHD.

Materials and methods: the review is formed on the basis of scientific articles published in international databases (PubMed, Cochrane Library, Cyberleninka). The search was carried out using the following keywords: “attention deficit hyperreactivity syndrome”, “ADHD”, “psychostimulants”, “psychotropic drugs without psychoanaleptic effect”.

Conclusion: the features of the development and evolution of ADHD over time, by the time the patient grows up, determine its clinical manifestations, they become more heterogeneous, which requires additional diagnostic efforts to clarify the diagnosis in order to select effective pharmacotherapy in combination with psychosocial methods of treatment. Currently, drugs with and without psychoanaleptic effect are used as drug therapy for ADHD. The most promising drugs for the treatment of ADHD are monoaminergic reuptake inhibitors, as well as drugs with melatonergic activity. Of considerable interest is the further study of drugs that affect the GABA system, glutamatergic and cannabinoid transmission in the brain. In general, the authors of analysed publications unanimously recognize that the problem of selecting effective therapy of ADHD in childs and adult patients requires further study and the proposal of new means of correction.
Drug Dependence Due to the Use of Barbiturates: The State of the Art
Authors: Titarenko E. V.
Published: September 2023

Background: currently, the relevance of the formation of drug dependence on barbiturates, despite a significant decrease in the cases of their prescription, remains prevalent. The breadth of the therapeutic effects of barbiturates determines their use in various branches of medicine, despite the risk of developing dependence and withdrawal syndrome, even in the case of taking therapeutic doses. In addition, the non-drug use of barbiturates in order to achieve a narcotic effect remains relevant.

The aim of review: to analyze the data of scientific publications on specific features of the formation of barbituric dependence in various categories of patients, to determine the groups at greatest risk and the possibilities of minimizing the consequences of barbiturate use.

Materials and methods: based on the analysis of databases (PubMed/MEDLINE, RSCI, etc.), the current concepts of mechanism of action of barbiturates and the ways of development of mental and physical dependence were analyzed. The factors provoking the emergence of drug dependence are determined.

Results: the development of drug dependence when taking barbiturates develops rapidly and is dose-dependent. The features of the formation of barbituric dependence and the development of tolerance are characterized. The risk of developing dependence in the therapeutic use of barbiturates is especially high in the elderly.

Conclusions: to prevent and possibly reduce the risk of drug dependence, the main areas of research are proposed, namely, the development of more effective and safe drugs analogs of barbituric acid, as well as the correction of the features of the use of barbituric acid drugs (frequency, dosage, dosage form, etc.).
EFFECT WORKLOAD ON WORK STRESS TO DISTRICT ATTORNEY EMPLOYEE IN SAMARINDA
Authors: Damayanti Desita Dyah , Fadilla Tasya , Alamanda Karina Putri , MSEPS2 Panitia
Published: September 2023

A workload is a number of activities carried out or the time given to complete work that is perceived by individuals as excess work activities, working hours, work pressure, and individual satisfaction levels. The many demands of work in the work environment make work stress appear. This study aims to see the effect between workload and work stress on employees of the Samarinda City Public Prosecutor's Office. The number of research samples in this study was 46 respondents. In data collection, the workload scale used consisted of 12 items with a Cronbach alpha of 0.850 and the work stress scale consisted of 13 items with a Cronbach alpha of 0.835. The results of this study indicate that workload has a significant and positive effect on work stress on employees of the Samarinda City Public Prosecutor's Office with a correlation coefficient of workload on work stress of 0.507 with p = 0.000 (p <0.05).
THE EFFECT OF PRODCUT QUALITY AND PRICE ON THE PURCHASE DECISION OF MOLTO PEWANGI IN ALFAMART PEMURUS DALAM REGION OF BANJARMASIN
Authors: MSEPS1 Panitia , Mailiana Mailiana , Budiati Penta Lestarini
Published: September 2023

The purpose of this study was to determine the effect of product quality and price partially and simultaneously on the purchase decision of Molto Pewangi at Alfamart Pemurus of Banjarmasin. The population in this study was 247 consumers of Molto Pewangi products who bought Molto products in 2021. Samples could be taken from 10% to 20% if the population is large or more than 100 (Arikunto, 1998: 120). Hence, the number of samples taken in this study was 50 people with the calculation, namely: F = 20% x 247 = 49.4 rounded to 50. The results of the study are based on the t-test that the product quality variable has a significant value of 0.001 < 0, 05 means that the hypothesis is accepted that product quality has a partial effect on purchasing decisions. Meanwhile, the price variable based on the t-test obtained a value of 0.33 > 0.001 which means the hypothesis is rejected that the price has no partial effect on purchasing decisions. Based on the results of the f test above, it shows a significance value of 0.001 <0.05. and the regression model can be used for decision making or it can be said that product quality and price have a simultaneous effect on purchase decisions.
THE EFFECT OF WORK DICIPLINE IN INCREASING EMPLOYEE PERFORMANCE AT CV DUTA BARITO BANJARMASIN
Authors: MSEPS1 Panitia , Hayati Diana , Sylvia Rika
Published: September 2023

CV Duta Barito Banjarmasin is a company that was initially engaged in selling raw rattan products and now sells finished products. The purpose of this study was to determine the effect of work discipline on employee performance at CV Duta Barito Banjarmasin. The type of research used is descriptive quantitative, where the sample in this study are employees in the production section, totaling 30 people. Sources of data in this study are primary data and secondary data. The data collection techniques used were through questionnaires, observation, interviews, and documentation. While the data analysis method was carried out on the results of the questionnaire answers using the SPSS for Windows version 23 program. The results of the study were from the work discipline variable that affected employee work performance, where discipline was evidence of a sense of responsibility for the tasks assigned to him, so that it would also have a positive impact. against the company. Where from the calculation shows that work discipline has a positive and significant effect on employee performance with a significant value of 0.000 and less than 0.05, which means that work discipline increases, employee performance will also increase with an influence value of 60.5%.
THE EFFECT OF PERCEPTIONS OF BENEFITS, RISK AND SERVICE FEATURES ON INTEREST IN USING SHOPEEPAY AMONG ACCOUNTING STUDENT
Authors: MSEPS1 Panitia , Agustina Ruslinda , Saputra Indra
Published: September 2023

The purpose of this study is to empirically prove the effect of perceived benefits, risks, and service features on the interest in using ShopeePay (on students majoring in accounting at STIE Nasional Banjarmasin). The research method used in this research is a quantitative method with a survey method through distributing questionnaires to students majoring in accounting at STIE Nasional Banjarmasin with a sample of 100 students who are respondents assisted by statistical tools using SPSS version 22.00 for Windows. The results of this study indicate that the perceived benefit variable affects the interest in using ShopeePay with a significance value of 0.020, the risk variable affects the interest in using ShopeePay with a significance value of 0.006, the service feature variable affects the interest in using ShopeePay with a significance value of 0.00. The results of the study simultaneously affect the interest in using ShopeePay with a significance value of 0.000. In conclusion, partially and simultaneously perceptions of benefits, risks and service features affect the interest in using ShopeePay among students majoring in accounting at STIE Nasional Banjarmasin. Suggestions for further researchers can add other variables such as convenience and trust that affect the interest in using e-money, and can expand the research sample.
Correlation of HbA1C and Lipid Profile Levels in Type 2 Diabetes Mellitus Patients at M Yunus Hospital
Authors: Handayani Dian , Reza Rahmawati , Dwi Dominica , Jihan Salsabila , Kurnia Hafidzah , Afra Wafiqah
Published: September 2023

The lipid profile in type 2 diabetes mellitus patients is highly dependent on the HbA1c value. Poor HbA1c values accompanied by insulin resistance are associated with hypertriglyceridemia, decreased HDL levels, and sometimes followed by increased LDL levels. The aims of this study was to determine the correlation between HbA1c and lipid profile of type 2 diabetes mellitus patients. This research was an analytic observational study with a cross sectional design with prospective method. The total sample of 35 patients seeking treatment at the Polyclinic Internal M Yunus hospital. There were lower levels of total cholesterol (158,83 ± 23,96; 201,51 ± 44,95; p=0,032), triglyceride (111,16 ± 48,06; 156,69 ± 76,07; p=0,169), LDL (80,83 ± 22,69; 121,96 ± 42,82; p=0,030) in type 2 DM patients with controlled glycemic control compared to those without control. There was no significant difference in triglyceride levels between on two groups (111,16 ± 48,06; 156,69 ± 76,07; p=0,169). There was a significant correlation between total cholesterol levels r=0,364; p=0,032), HDL (r=-0,377; p=0,026); LDL (r=0,367; p=0,030) with HbA1c levels. Type 2 DM patients with good glycemic control had significantly lower total cholesterol, triglyceride, and LDL levels compared to type 2 DM patients with poor glycemic control.

Keywords: hba1c, lipid profile, type 2 diabetes mellitus
Effectiveness Test of Ketapang Leaf Ethanol Extract (Terminalia catappa L.) with TWEEN and PEG Diluents on the Mortality of Aedes aegypti Larvae
Authors: Azmi Aninditha Syavela , Nurhayani Nurhayani , Bestari Rochmadina Suci , Sintowati Retno
Published: September 2023

Diseases caused by Aedes aegypti mosquitoes can be controlled with vectors in the form of larvicide administration, but if it is excessive, it causes environmental pollution and causes larval resistance so that natural larvicides are needed. Ketapang leaves are tested to determine the effectiveness of larvicides against Aedes aegypti larvae. To determine the effectiveness of the ethanol extract of ketapang leaves (Terminalia catappa L.) with TWEEN dilution on the mortality of Aedes aegypti larvae. The research is experimental with the research design used is posttest only controlled group design. This design compares the experimental group with the control group. The groups used were groups K (+) and K (-), and the TWEEN/PEG treatment group which contained ketapang leaf extract with a concentration of 1,5% and 2%, respectively. The sample of Aedes aegypti larvae used was instar III IV. Normality, Kruskal-Wallis, Mann-Whitney and Probit tests are used for data processing. Mortality was highest with his PEG treatment at 1,5% and lowest with TWEEN at 2%. The effect of ethanol extract from ketapang leaves (Terminalia catappa L.) with TWEEN diluent was the same as PEG on the mortality of Aedes aegypti larvae. The ethanol extract of ketapang leaves (Terminalia catappa L.) with dilutions of TWEEN and PEG was less effective than abate.
REDUCTION OF THE STRATIFICATION PERIOD OF GRAFTED GRAPE SEEDLINGS OF THE CABERNET SAUVIGNON VARIETY
Authors:   Vserossiyskiy nauchno-issledovatel'skiy institut vinogradarstva i vinodeliya imeni YA.I. Potapenko - filial Federal'nogo gosudarstvennogo byudzhetnogo nauchnogo uchrezhdeniya «Federal'nyy Rostovskiy agrarnyy nauchnyy tsentr», GRIGORIEV A.A.
Published: September 2023

In recent years, one can observe a tendency to expand the area of grape plantations, due to the active support of the industry by the state. To this end, an experiment was set, the task of which was to increase the yield of first-class grape seedlings obtained in the shortest possible time. To achieve this goal, grape cuttings were treated with solutions of preparations that increased the yield of first-class seedlings by 15% compared to the control variant.
Autarky metal roofing at the Mecenate Paper Mill in Tivoli: an unseen application of Gino Covre’s patents
Authors: Currà Edoardo , De Pace Andrea , Rocchi Riccardo , D'Amico Alessandro , Russo Martina , Angelosanti Marco , De Matos Ana Cardoso , Julian Sobrino Simal Vincente
Published: September 2023

In 1887, the Papermill Mecenate settled at the Sanctuary of Hercules the Victor in Tivoli, thanks to the construction of the Canevari Canal. The papermill represented, for decades, the largest industrial plant placed on the former religious site, which had already housed various manufacturing functions. The phases of greatest overlap occurred in the 1930s and 1950s by engineer Emo Salvati, who designed many reinforced concrete structures. In 1938, he and Marco Segrè, the factory owner, approached Gino Covre to make lightweight metal roofing. Arrived in Rome in 1935, Covre was already working steadily with the Antonio Badoni firm in Lecco. In Rome, he registered many patents, including the one for “Vaulted arch, composed or constituted with frame elements” (1936). The paper presents the historical-constructional investigation, supported by digital information modeling, of two unpublished applications made by Covre that were lost in the late 20th century. Covre’s Rome period is under-explored, and the case study raises important questions about those early years. The loss of vaults gives greater emphasis to existing traces-photographic, documentary-that can provide insights into the lost built object. Gino Covre’s experimentation in the autarkic phase with metal structures by means of a significantly reduced use of material appears to be an exceptional issue, and the application of Tivoli tests the system later used at the Palace of Congress at E42 designed by Adalberto Libera.
Substance Abuse Poisoning Registry development Based on Lessons Learned from a Pilot Implementation
Authors: Badali Borhan , Jebraeily Mohamad , Delirrad Mohammad , Boushehri Behzad , Pahlevanynejad Shahrbanoo
Published: September 2023

Introduction: Substance abuse has been recognized as a national problem in which poisoning with pharmaceutical drugs, opioids and alcohols is a common problem in Iran. Due to the lack of a comprehensive information system related to Substance abuse, despite the systematic information in health services, and to achieve this goal, the purpose of this research was to develop a registry system for substance abuse poisoning in - Urmia University of Medical Sciences.Material and Methods: This research is a practical development study that was done in 4 phases. In the first phase, minimum data set (MDS) of the system were determined. In the second phase, the registration system was designed. The third phase includes the implementation of the system, and finally, the system was evaluated by QUIS questionnaire.Results: A total of 58 data elements in 6 classes were recognized as essential for this system from the point of view of experts. The system was implemented on the ASP.NET platform using C# language and SQL Server database in the poisoning department of Taleghani Hospital in Urmia. The evaluation of usability of the system showed score obtained in the 6 main categories were in set of terms of the system 8.52, screen 8.36, ability to learn 8.8, overall functionality 8.04, user interface 7.98, and the overall interaction is 7.73 respectively.Conclusion: Considering the capabilities of the system for registering poisonings caused by drug abuse, it seems necessary to implement this system in the form of a national network, in order to make the necessary interventions to control drug abuse while using resources efficiently.
Effect of boric acid and quercetin combination on oxidative stress/ cognitive function in parkinson model
Authors: YAVUZ Elif , ÇEVİK Güven , ÇEVRELİ Burcu , SERDAROĞLU KAŞIKÇI Emel
Published: September 2023

Parkinson's disease (PD) is a one of the important neurodegenerative disorders that affect dopaminergic neurons in the brain. Quercetin is one of the most potent antioxidants among all flavonoids, with direct radical scavenging activities and induction of antioxidative enzymes. Studies have shown that boric acid is essential for the activity of brain functions. We also used 3-month-old Wistar-albino male rats in our study, the experimental groups were divided into 8 groups (n=7) and Glutathione (GSH) and Malondialdehyde (MDA) levels were determined manually in brain tissue samples. Also, Total Antioxidant Status (TAS) was determined using a commercial kit. Locomotor Activity and Object Recognition tests were applied to evaluate the cognitive functions of the rats. GraphPad Prism 9 version was used for statistical analysis. Values were statistically analyzed by one-way ANOVA, differences between groups were determined using Uncorrected Fisher's LSD tests. p < 0.05 was considered statistically significant. In our study, we think that BA will positively affect the oxidant-antioxidant balance by preventing the pathogenesis of PD.
STONE INVENTORY OF THE CHES-TYI-YAG NEOLITHIC SETTLEMENT
Authors:   National Research Tomsk State University, Vasiliev Evgeny A. ,   Museum of Seversk, Kosinskaya Lyubov L. ,   Ural Federal University
Published: September 2023

Ches-tyi-yag is the most important defining site of the Middle Neolithic Lower Ob region with ceramics of the Chestyag cultural type. The collection of stone inventory from five dwellings and two buildings, investigated by excavations, is distinguished by cultural homogeneity, seriality of mor¬photypes of tools and debitage. The article for the first time analyzes in detail the collection of flint inventory of the settlement (1 139 items) from the standpoint of technical, morphological and typological approaches. Grinded tools and abrasive tools are not considered. In all dwellings, the same varieties of flint were used, quartz products are rare. The industry is characterized as flaking: stadial concrete-situational direct percussion is combined with bipolar technique. A few blades are more often irregular. Among the tools, scrapers of various shapes and flakes with edge retouching predominate, designed for performing cutting, scraping, sawing functions. Small chisel-shaped tools are typical, there are perforators and carvers, and combined tools are frequent. Arrowheads on large irregular blades carry a double-sided edge retouching. The technique of incisor chipping was not used. The bipolar technique was also used to form the blades and rear parts of the tools (undercutting, thinning and reworking the implements), as well as for fragmentation and re-registration of finished tools. The flint inventory of the Ches-tyi-yag settlement according to the technique of splitting, of course, belongs to the circle of the taiga Neolithic of Western Siberia, representing the original flint flake industry with a bright typologically pronounced tool set.
ASTRAKHAN’S ARMENIAN COMMUNITIES IN THE MID-18TH CENTURY: THE ANATOMY OF URBAN RELIGIOUS CONFLICT
Authors:   Independent Researcher, Ryazhev Andrey S.
Published: September 2023

The article concentrates on the religious policy of the Russian Empire in the Early Modern Time. It considers the conflict between Armenian Gregorian and Catholic communities in the town of Astrakhan, 1755–1760. The author traces the objective prerequisites of the conflict (confessional hostility, economic contradictions, and the desire of the community leaders to take a prominent place in relation to the Russian authorities in the center and in the region). Further, the study indicates the areas in which this conflict manifested itself most often — family relations, the choice of confession of children born in mixed marriages, inheritance of property. Finally, the typological nature of such conflicts is revealed, precisely their conditionality by ambiguous, tangled inter-confessional relations in the urban surrounding. The author concludes that the analyzed conflict was a particular case of urban social competition in the light of the complication of religious life noted in Astrakhan.
THE ORIGIN OF ADVERTISING IN THE RUSSIAN PROVINCE (BY THE EXAMPLE OF MERCHANT’S ANNOUNCEMENTS IN THE “VOLOGDA PROVINCIAL GAZETTE” OF THE SECOND THIRD OF THE 19TH CENTURY)
Authors:   Pitirim Sorokin Syktyvkar State University, Leyman Irina I. ,   Institute of Language, Literature and History, Federal Research Centre Komi Science Centre, Ural Branch of the RAS
Published: September 2023

In the 19th — early 20th centuries Russian Empire the main advertising load fell precisely on periodicals, which determines the importance of advertisements in the periodicals as a source on the history of regional entrepreneurship and trade. Researchers have repeatedly emphasized the significant role of a provincial gazette as an advertising medium. The article considers advertisements published by merchants in the Vologda Provincial Gazette from the first issue in 1838 to 1860. The dynamics of the number of advertisements demonstrates, first, a gradual increase in the importance of the Gazette as a regional mass media and the understanding of this trend by merchants; second, a general intensification of the role of advertising in the field of entrepreneurship. The geography of advertisements correctly reflects the system of trade relations in the province. The subject matter of the ads was quite diverse (haberdashery, printed materials, raw materials, foodstuffs, household goods) and covered mainly elite groups of goods, although agricultural raw materials accounted for a significant share of the advertising objects. An analysis of the ads genre specificity indicates the predominance of narrative ones; the incentive function largely begins to manifest itself in the texts of the 1850s. Graphic design of advertisements in the period under review can be already encountered, but it is not widespread.
THE ADMIRAL AND THE MERCHANTS: FROM THE HISTORY OF COMMERCIAL AND INDUSTRIAL DEVELOPMENT OF THE PECHORA AND OB IN THE 1840S–1860S
Authors:   Tyumen Scientific Center, Tyumen State University, Agapov Mikhail G.
Published: September 2023

The article considers a little examined aspect of the history of Russian entrepreneurship associated with the risky nature of commercial and industrial development of the Russian imperial northern periphery. The central plot of the study is the business partnership of the famous navigator and scientist, Admiral P. I. Kruzenshtern and prominent figures of the Russian northern entrepreneurship of gold miners and merchants V. N. Latkin and M. K. Sidorov within the framework of the Pechora-Ob Company formed by them in 1858 for the development of industry, shipping and trade in the Northern Ocean along the Pechora and Ob rivers. Based on a detailed analysis of the company’s design, organizational and logistics activities, it is concluded that the reasons for its collapse in the mid-1860s cannot be explained only by objective factors noted in historiography such as insufficient support from the state, opposition from officials and competitors. The bankruptcy of the company was largely due to subjective reasons. Thus, the idea of the excessive wealth of natural resources of Russia’s North and the possibility of their easy extraction prevented P. I. Kruzenshtern, V. N. Latkin and M. K. Sidorov from adequately assessing the complexity of the organizational and logistical tasks facing them. The propensity of the partners to being visionary, their reliance on luck and mutual accusations of the failure of the enterprise without analyzing their own miscalculations are no less important part of the history of the Pechora-Ob company. Without taking account of such subjective factors in the implementation of innovative commercial projects, the enormous experience of domestic northern entrepreneurship cannot be analyzed comprehensively and used by the next generations of entrepreneurs in full measure.
FOREST INDUSTRY AND REGIONAL DEVELOPMENT OF THE SOVIET NORTH DURING THE FIRST FIVE-YEAR PLANS
Authors:   Institute of History and Archaeology, Ural Branch of the RAS, Zykin Ivan V. ,   Ural Federal University
Published: September 2023

The purpose of the article aims at studying the timber industry in the conditions of the formation of regional administrative-territorial and economic structures in the north of the Soviet Union during the first five-year plans. The forestry industry had to ensure the export of forest resources and materials to obtain foreign exchange funds and meet the domestic needs of the country. Plans for the development of the industry and their implementation turned out to be closely related to the administrative and territorial transformations in the 1920s and 1930s, the creation and functioning of economic organizations. In the poorly developed northern and eastern regions of the country, they became a significant trump card in the actions of party-state and economic figures. This led to a number of contradictions and conflicts, which is shown by the examples of Northern Krai and the Igarka district. The potential of the decisions taken turned out to be short-lived — to achieve specific, narrow goals, but at the same time affected large territories. The result of the regional and economic — in relation to the forest industry — policy of the Soviet government was, in addition to the unbundling of the regions, the gradual reorientation of the industry to meet domestic needs. This process was based on the production and transport infrastructure created in the late 1920s — early 1930s for the export of wood. The projects of enterprises designed for meeting the domestic needs of the country, for the most part, have not been implemented.
VYAZNIKOVTSY IN THE BUSINESS AND SOCIAL LIFE OF EKATERINBURG OF THE 19TH — EARLY 20TH CENTURIES
Authors:   Institute of History and Archaeology, Ural Вranch of the RAS, Mikityuk Vladimir P.
Published: September 2023

The article analyzes the class and territorial affiliation of the Vyaznikovians (Vyaznikovtsy, natives of the Vladimir province), who became Ekaterinburg merchants, the time of their appearance in the Middle Urals, the time of registration in the Ekaterinburg merchant class, as well as their role in the development of the city’s commercial, industrial and social activities. The research is based on historical-genetic and statistical methods. It is concluded that Vyaznikovtsy did not belong to the leading sources of the Ekaterinburg merchant class of the 19th — early 20th centuries, as their specific weight rarely exceeded 10 %. Much attention is paid to the study of areas of entrepreneurial activity practiced by the them. It is concluded that Vyaznikovtsy preferred trade, selling groceries, haberdashery and manufactory goods, and had relatively little interest in production activities. The article notes that some of them were interested in gold mining and some industries. They mostly founded small enterprises, but in some cases, there were large enterprises well equipped technically. This was especially the case in the flour-milling industry. The article pays attention to the participation of Vyaznikovtsy in the social life of Ekaterinburg, which largely consisted in close cooperation with the local government, as well as in a variety of charitable activities.
DEVELOPING THE GENERAL PLAN FOR SVERDLOVSK IN THE 1930S: PROBLEMS AND FEATURES
Authors:   Ural Federal University, Dumchikov Aleksandr A.
Published: September 2023

The article considers developing a master plan for the city of Sverdlovsk during the period of the prewar five-year plans, when the active industrial development of the adjacent territories began. Architects and urban planners were faced with the task of regulating the order of building, integrating the satellites into a single city system and creating the foundation of the city’s systematic development in the future. However, the lack of funds and skills, as well as changing plans for the national economy’s development led to the fact that work on the general plan dragged on for more than a decade. Construction in the absence of the plan led to a significant expansion of the city due to the emergence of workers’ settlements and towns remote from the historic center and the main urban areas, and identified the lack of a unified system in the ensemble of the central part of the city as well. The article describes the major steps of drafting the territorial distribution schemes and the city’s general plan in the 1930s, as well as the expert assessment of these works by the People’s Commissariat of Communal Services of the RSFSR, the Union of Soviet Architects and regional specialists. Despite the fact that the city’s general plan developed by the end of the 1930s has not been implemented due to the outbreak of the Great Patriotic War, the specifics of deploying design works during the studied period determined the vector of development of Sverdlovsk for many decades.
A SYMBOLIST IN WARTIME SVERDLOVSK: YURY N. VERKHOVSKY’S LATE WORKS IN THE LIGHT OF THE IDEAS OF VYACH. I. IVANOV AND A. N. VESELOVSKY
Authors:   Institute of History and Archaeology, Ural Вranch of the RAS, Mashtakova Liubov V.
Published: September 2023

The article is devoted to Yury N. Verkhovsky’s scientific and poetic works of the period of the Great Patriotic war evacuation to Sverdlovsk (1941–1944). Its goal is to explore the options for transforming the Russian symbolism ideas in Soviet official literature. The material for the study includes poetry (the collection of poems Budet Tak [It Will Be So], 1943; poems published in the press), articles, reports, reviews by Verkhovsky and a memoirs and reviews of his contemporaries. Some excerpts from Verkhovsky’s works published in the newspapers Uralsky Rabochiy [The Ural Worker] and Literatyrny Ural [Literary Ural] are analyzed and re-published for the first time. Based on a comparative and hermeneutic analysis of this material, it is shown that the ideas of the presence and development of a special poetic language, and of a special “plastic force” that filling and driving a work, and of a continuity in literature (genre, motif), which were perceived him from the poet and philologist Aleksander N. Veselovsky, were consistently developed in his articles and reports and formed an original theory of the classification of types of poetic creativity (“the singer”, “the plastic artist”, “the sage”) and found practical application on the Ural literary material. Taking an active part in the literary life of the Urals, Verkhovsky saw there the formation of a renewed Russian/Soviet classics, successive in relation to the “Golden age” of Russian literature and ancient classical examples. A special place is given to the personality and work of the Ural writer Pavel P. Bazhov in the reception of Verkhovsky. A hypothesis is made about the closeness of Bazhov, from the point of view of Verkhovsky’s concept, to symbolism. An analysis of the corpus of Verkhovsky’s wartime lyrics shows how his aesthetic and poetological views, supplemented by ideas which were perceived him during the years of apprenticeship with Ivanov, were embodied in the themes, motifs, forms that he used, showing, thus, an example of an original combination of artistic and philosophical discoveries of the Silver Age with current themes and pathos of the Soviet press.
VERTICAL BURIALS OF NORTHERN EURASIA
Authors:   Tyumen Scientific Center, Siberian Branch of the RAS, Zakh Viktor A.
Published: September 2023

At this point, eight burials with vertically positioned bodies in the burial chamber are known in Northern Eurasia from Central Europe to the eastern border of Western Siberia. There is one “stand up” burial at each of the following sites: near the village of Zarechnoe on the Ina River in the Ob River area, in the Tobol River area near the village of Pegan, at Ust-Aleika 5 burial ground on the Upper Ob River, and Central Europe, 80 km north of Berlin. The remains of four burials are known at Oleniy Ostrov burial ground on Lake Onega. Vertical burial grounds are characterized by some significant peculiarities. Bones of a child from Ust-Aleika 5 necropolis, female bones from Zarechnoe 1 burial ground, and, probably, from the burial near the village of Pegan were found in anatomical order. Female burial № 68 at Oleniy Ostrov burial ground can be considered vertical, too. The deceased was buried standing up there. A burial of a man in an upright position was found at a burial ground in Groß Fredenwalde. Biting marks and mixed condition of the bones reliably indicate that the upper part of the grave pit was open for some time. Accordingly, we can assume a similar rite (with the upper part of the grave opened) at burial № 68 and diagonal burials № 100, 123, and 125 at Oleniy Ostrov burial ground. Considering relatively sparse funerary equipment in vertical burials, an almost total absence of sculptural images, which, in our opinion, are more typical of shaman burials, and, probably, the practice of building half-open graves, we can assume that the deceased buried in “stand up” burials were not shamans. They were apparently revered according to the religious code in a special way due to certain mental or physical abilities or shortcomings, which is indicated by the example of a child with hydrocephalus from Ust-Aleika 5 burial ground. The vertically buried bodies were likely to serve as a kind of “guardians” at the necropolises, as evidenced by the burial at Groß Fredenwalde that was half-opened for some time, and, possibly, by the burials on Oleniy Ostrov.
HOLOCENE OF THE MIDDLE TAIGA SUBZONE OF WESTERN SIBERIA ACCORDING TO PALYNOLOGICAL DATA OF THE SECTION IN THE VALLEY OF THE R. MULYMYA
Authors:   Botanical Garden, Ural Branch of the RAS, Antipina Tatiana G. , Reinhold Sabina ,   German Archaeological Institute, Chairkina Natalia M. ,   Institute of History and Archaeology, Ural Branch of the RAS, Zorina Alesya A. ,   Botanical Garden, Ural Branch of the RAS
Published: September 2023

The purpose of the research was a comprehensive palaeoecological study of peat deposits from a core in the floodplain of the Mulymya river, reconstruction of changes in climatic parameters and vegetation in the Holocene according to spore-pollen analysis (SPA) and radiocarbon dates. In the course of the study, new data were received from the SPA of the Mulymya core, provided with a series of AMS dates, which made it possible to record changes in climatic parameters and the transformation of forest formations of the Konda left-bank middle taiga province for the period 10180–2720 BP / 8463–977 BC. In the late glacial period (up to 10,000 BP / 8250 BC), the territory represented open spaces with widespread permafrost. In the Early Holocene, 9750–8200 BP / 7750–650 BC, the expansion of woody vegetation began: there was an expansion of forest areas from sparse forests to closed forests. From the beginning, woody vegetation grew in islands of open spruce forests with an admixture of larch and birch with a moss-shrub cover. Pine and birch dominated in the composition of forests by the Middle Holocene, spruce, larch, fir and Siberian cedar were found in admixtures. The instability of the climate is reflected in the variegated stratigraphy of the peat deposit: the alternation of sedge-cotton grass and woody peat with the participation of sphagnum mosses indicates to the hydrological regime fluctuations. The Late Holocene (from 4760–3670 BP / 2850–1650 BC) is characterized by relatively stable climatic conditions; spruce-cedar-pine forests grew in the territory under consideration. The floodplain communities were represented by sedge-cotton grass associations. From 3670 to 2900 BP / 1650–1100 ВС, the floodplain was afforested, which is indicated by the remains of wood in the peat.
EUROPEAN INTEGRATION STRATEGY FOR TOURISM DEVELOPMENT OF UKRAINE
Authors: PUZYROVA Polina
Published: September 2023

The purpose of this article is to investigate the essence and features of the implementation mechanism of the European integration strategy for the development of tourism in Ukraine.

Methods of research. The article uses general scientific methods of researching economic phenomena: epistemological analysis, theoretical generalization, methods of analysis and synthesis, induction and deduction, structural-logical analysis, extrapolation, grouping and classification.

Presentation of the main research material. The tourism industry of Ukraine is one of the first to suffer large-scale losses with the start of a full-scale war in Ukraine. The state budget did not receive almost 35% from the tourism industry, which was caused by the suspension or complete exit of tourist companies from the Ukrainian market of the tourism industry. The European integration process of tourism development in Ukraine consists in the implementation of European norms and standards, the spread of its own cultural, historical, geographical achievements in the EU countries. This will lead to the adaptation of European cultural identity in Ukraine and general integration into the European environment. Therefore, one of the key tasks of the Ukrainian tourism industry is the need to actively continue the implementation of the adopted strategic course for European integration through the mechanism of implementing the European integration strategy for the development of tourism in Ukraine. That is why the mechanism for the implementation of the European integration strategy for the development of tourism in Ukraine is becoming relevant, since only with the help of integration into the European space and the adoption of European laws, standards, norms and rules will Ukraine be able to revive and ensure the appropriate level of safe and high-quality tourist flow of Ukrainian tourists to EU countries and others.

Conclusions from the conducted research. It was revealed that as a result of comprehensive actions regarding the implementation of the European integration strategy for the development of tourism in Ukraine, the following advantages will occur: the competitiveness of national and regional tourism products will increase with the prospect of expanding to European markets; the quality of life of the population will increase by ensuring socio-economic growth, environmental safety, consolidation of society, providing access to services in the field of tourism according to European standards; the emergence of new jobs and the expansion of the population's opportunities for employment and self-employment; creation of a modern tourist information industry, as well as ensuring information freedom about the tourist resources of Ukraine in the global information European space.

Keywords: European integration strategy; integration processes; tourism development of Ukraine; tourism industry; mechanism of implementation of European integration strategy; tourism industry; competitiveness; European space; tourist flow.
Probiotic activity of Bacillus subtilis metabolites in experimentally induced dysbiosis in mice
Authors: Lazarev S. А. , Vartanova N. O. , Poddubikov A. V. , Mikhailova N. A.
Published: September 2023

Scientific relevance. A promising option for dysbiosis correction is the use of metabiotics, products based on metabolites of probiotic microorganisms. During fermentation, Bacillus subtilis bacteria (strains 3H and 1719) produce metabolites that exhibit probiotic properties in vitro. These observations in vitro motivate an in vivo investigation of B. subtilis metabolite effects on colonic mucosal microbiota in mice in experimentally induced dysbiosis and an assessment  of the potential of B. subtilis metabolites as metabiotics.

Aim. The authors aimed to compare the probiotic activity of B. subtilis 3H and B. subtilis 1719 metabolites and a commercial metabiotic in antibiotic-induced dysbiosis in mice.

Materials and methods. The authors induced experimental dysbiosis in BALB/c mice weighing 18–20 g by intraperitoneal injection of gentamicin. For subsequent correction, the test groups received sorbent-bound B. subtilis metabolites, and the comparison group received a commercial metabiotic containing B. subtilis metabolites (VKPM B-2335(3)3) via intragastric injection   for 21 days. The quantitative and qualitative analysis of colonic mucosal microbiota included microbial culturing and colony identification by MALDI-TOF mass spectrometry.

Results. Antibiotic-induced colonic dysbiosis in mice manifested itself as a decrease in the dominant microbiota and an increase in opportunistic pathogens. After 7 days of metabolite administration, the Lactobacillus population returned to normal in all treatment groups. The mice that received B. subtilis 3H metabolites showed the best results: their Lactobacillus spp. composition corresponded to that of intact animals. The content of Lac+ Escherichia coli returned to 100%   in all treatment groups. After 21  days  of  metabolite  administration,  the  authors  observed the elimination of bacteria (Rodentibacter spp., Aerococcus spp.) and fungi (Trichosporon spp., Kazachstania spp.) in the B. subtilis 3H group; Trichosporon spp. (no effect on Kazachstania spp.) in the B. subtilis 1719 group; and Enterococcus spp., Kazachstania spp., and Trichosporon spp. (no effect on Rodentibacter spp. and Aerococcus spp.) in the commercial metabiotic group.

Conclusions. Metabolites of B. subtilis strains 3H and 1719 help to restore the diversity and abundance of  colonic  microbiota  in  antibiotic-induced  dysbiosis.  The differences  observed in microbiota re-establishment in the treatment groups indicate that there is interstrain variability in the probiotic activity of B. subtilis metabolites.
Field electron spectroscopy of oxide thermocathode
Authors:   Moscow Institute of Physics and Technology (National Research University), 141700, Dolgoprudny, Moscow region, Institutskiy per., 5, Lobanov V.M. , Sheshin E.P. ,   Moscow Institute of Physics and Technology (National Research University), 141700, Dolgoprudny, Moscow region, Institutskiy per., 5, Lobanov S.V. ,   Moscow Institute of Physics and Technology (National Research University), 141700, Dolgoprudny, Moscow region, Institutskiy per., 5, Chadaev N.N. ,   Moscow Institute of Physics and Technology (National Research University), 141700, Dolgoprudny, Moscow region, Institutskiy per., 5
Published: September 2023

The results of a detailed measurement of the dynamics of changes in the energy spectra of emitted electrons of non-activated and activated oxide thermocathodes with an increase in the emission voltage and cathode temperatures of 590 °C and 600 °C are presented; the changes in the spectra corresponded to the spotted cathode model. The results of measuring the energy spectrum of emitted electrons of a separate elementary emitting spot of an oxide thermocathode are presented, the spectrum had a Gaussian shape and was distinguished by a record narrow FWHM equal to 120 meV.