bluuebunny/crossref_metadata_2025 huggingface dataset:
Study of the Complexity of CMOS Neural Network Implementations Featuring Heart Rate Detection
Authors: Baryczkowski Piotr , Szczepaniak Sebastian , Matykiewicz Natalia , Perz Kacper , Szczęsny Szymon
Published: October 2023

The growing popularity of edge computing goes hand in hand with the widespread use of systems based on artificial intelligence. There are many different technologies used to accelerate AI algorithms in end devices. One of the more efficient is CMOS technology thanks to the ability to control the physical parameters of the device. This article discusses the complexity of the semiconductor implementation of TinyML edge systems in relation to various criteria. In particular, the influence of the model parameters on the complexity of the system is analyzed. As a use case, a CMOS preprocessor device dedicated to detecting heart rate in wearable devices is used. The authors use the current and weak inversion operating modes, which allow the preprocessor to be powered by cells of the human energy harvesting class. This work analyzes the influence of tuning hyperparameters of the learning process on the performance of the final device. This article analyzes the relationships between the model parameters (accuracy and neural network size), input data parameters (sampling rates) and CMOS circuit parameters (circuit area, operating frequency and power consumption). Comparative analyses are performed using TSMC 65 nm CMOS technology. The results presented in this article may be useful to direct this work with the model in terms of the final implementation as the integrated circuit. The dependencies summarized in this work can also be used to initially estimate the costs of the hardware implementation of the model.
Obstacle Avoidance for Automated Guided Vehicles in Real-World Workshops Using the Grid Method and Deep Learning
Authors: Li Xiaogang , Rao Wei , Lu Dahui , Guo Jianhua , Guo Tianwen , Andriukaitis Darius , Li Zhixiong
Published: October 2023

An automated guided vehicle (AGV) obstacle avoidance system based on the grid method and deep learning algorithm is proposed, aiming at the complex and dynamic environment in the industrial workshop of a tobacco company. The deep learning object detection is used to detect obstacles in real-time for the AGV, and feasible paths are generated by the grid method, which ultimately finds an AGV obstacle avoidance solution in complex dynamic environments. The experimental results showed that the proposed system can effectively identify and avoid obstacles in a simulated tobacco production workshop environment, resulting in the average obstacle avoidance success rate of 98.67%. The transportation efficiency of cigarette factories is significantly improved with the proposed system, reducing the average execution time of handing tasks by 27.29%. This paper expects to provide a reliable and efficient solution for AGV obstacle avoidance in real-world industrial workshops.
A Dual Convolutional Neural Network with Attention Mechanism for Thermal Infrared Image Enhancement
Authors: Gao Pengfei , Zhang Weihua , Wang Zeyi , Ma He , Lyu Zhiyu
Published: October 2023

In industrial applications, thermal infrared images, which are commonly used, often suffer from issues such as low contrast and blurred details. Traditional image enhancement algorithms are limited in their effectiveness in improving the visual quality of thermal infrared images due to the specific nature of the application. Therefore, we propose a dual Convolutional Neural Network (CNN) combined with an attention mechanism to address the challenges of enhancing low-quality thermal infrared images and improving their visual quality. Firstly, we employ two parallel sub-networks to extract both global and local features. In one sub-network, we utilize a sparse mechanism incorporating dilated convolutions, while the other sub-network employs Feature Attention (FA) blocks based on channel attention and pixel attention. This architecture significantly enhances the feature extraction capability. The use of attention mechanisms allows the network to filter out irrelevant background information, enabling more flexible feature extraction. Finally, through a simple yet effective fusion block, we thoroughly integrate the extracted features to achieve an optimal fusion strategy, ensuring the highest quality enhancement of the final image. Extensive experiments on benchmark datasets and real images demonstrate that our proposed method outperforms other state-of-the-art models in terms of objective evaluation metrics and subjective assessments. The generated images also exhibit superior visual quality.
Study on Breakage Characteristics and Anti-Breakage Theory for Pressure-Relieved CBM Drainage by Surface Wells in Coalbed Groups Covered by Super-Thick Pedosphere
Authors: Liu Zegong , Shen Sihuai , Liu Jian , Cai Feng , Gao Kui
Published: October 2023

During the mining of highly gassy and low-permeability coalbed groups, massive pressure-relieved desorbed coal bed methane (CBM) is stored in the fracture zone and in the gob under the impact of mining activities. Surface wells can cross the fracture zone and the gob to drain a large amount of highly concentrated pressure-relieved CBM. CBM drainage by surface wells is an effective technology for disaster control. However, it is difficult to drill or maintain surface wells in the mining disturbance zone and overlying strata in the gob. The keyisto prevent the surface wells in the mining disturbance zone from being broken and to keep the whole surface wells unblocked. This study adopted a variety of research methods, including similar-material simulation in laboratory, numerical simulation, onsite monitoring and industrial tests. Specifically, the strata structure of surface wells for pressure-relieved CBM drainage was explored, and the characteristics of roof strata movement and stress redistribution under coalbed group mining were analyzed. Besides, positions where the surface wells are prone to breakage were found. Furthermore, based on the mechanical analysis and breakage characteristics of surface wells, the anti-breakage principle of “resistance and dodge” and the surface well completion and protection method of “upper stop and lower leak” were proposed. The proposed theory and method were then applied to pressure-relieved CBM drainage surface wells in a coalbed group covered by the super-thick pedosphere in the Huainan Coal Field. The application results indicate that the proposed theory and method succeeded in solving the breakage of surface wells and realizing the smooth transport of CBM product. The surface wells can completely resist the mining disturbance, achieving an average single-well pure CBM production of 2.71 million m3, an average service period of 482 d, and a maximum pure CBM production of 4.32 million m3.
Design of a Tree Micro Drill Instrument to Improve the Accuracy of Wood Density Estimation
Authors: Yao Jianfeng , Wu Zhenyang , Zheng Yili , Rao Benqiang , Li Zhuofan , Hu Yunchao , Nie Bolin
Published: October 2023

To improve the estimation accuracy of wood density and study the linear correlation between drill feed resistance and wood density, a new micro drill instrument prototype that can simultaneously measure the rotation resistance and feed resistance of the drill needle was designed. The test tree species included hard and soft broad-leaved trees and coniferous trees, and the absolute dry density of each wood sample was measured. The drill resistance data were tested by our newly proposed prototype and a Resistograph 650-SC, and four linear models were established to define the relation between drill resistance and the absolute dry density of the wood. The results showed that (1) the statistical indicators of each model for our proposed prototype were better than the corresponding indicators of the Resistograph 650-SC for three of the four species tested; (2) the coefficient of determination of the linear regression model between the feed resistance of our proposed prototype and the absolute dry density of wood was 0.946; and (3) the statistical indicators of the model that included rotation resistance and feed resistance were better than those of the model that only including rotation resistance. Although the proposed prototype produced a competitive level of accuracy and explicitly demonstrated that including feed resistance improved wood density measurement accuracy, the prototype should be considered a first iteration as further hardware design changes and in-forest performance assessments across wider diverse set of test species are required before a conclusive evaluation can be rendered.
Constructing a Model of Poplus spp. Growth Rate Based on the Model Fusion and Analysis of Its Growth Rate Differences and Distribution Characteristics under Different Classes of Environmental Indicators
Authors: Zhang Biao , Liu Guowei , Feng Zhongke , Zhang Mingjuan , Ma Tiantian , Zhao Xin , Su Zhiqiang , Zhang Xiaoyuan
Published: October 2023

Poplar (Poplus spp.) is an important forest species widely distributed in China of great significance in identifying factors that clearly influence its growth rate in order to achieve effective control of poplar growth. In this study, we selected 16 factors, including tree size, competition, climate, location, topography, and soil characteristics, to construct linear regression (LR), multilayer perceptron (MLP), k-nearest neighbor regression (KNN), gradient boosting decision tree (GBDT), extreme gradient boosting (XGB), random forest (RF), and deep neural network (DNN) models based on the poplar growth rate. Using model fusion methods, the fitting accuracy and estimation capability were improved. The relative importance of each variable in estimating the poplar growth rate was analyzed using the permutation importance evaluation. The results showed the following: (1) the model fusion approach significantly improved the estimation accuracy of the poplar growth rate model with an R2 of 0.893; (2) the temperature and precipitation exhibited the highest importance in poplar growth; (3) the forest stand density, precipitation, elevation, and temperature had significant variations in growth rates among different-sized poplar trees within different ranges; (4) low-forest stand density, high-precipitation, low-elevation, and high-temperature environments significantly increased the poplar growth rate and had a larger proportion of large-sized individuals with high growth rates. In conclusion, environmental factors significantly influence poplar growth, and corresponding planting and protection measures should be tailored to different growth environments to effectively enhance the growth of poplar plantations.
Influence of Pomegranate Appearance Attributes on Consumer Choice, and Identification of Barriers and Drivers for Consumption
Authors: Pons-Gómez Ana , Albert-Sidro Carlos , Bartual Julián , Yuste Ferrán , Besada Cristina
Published: October 2023

In a prepurchase situation, consumers base their choice decision on external fruit characteristics, from which they infer internal characteristics. This study investigates consumer preference for pomegranate appearance using a choice-based conjoint analysis with 320 participants. We created 27 images of pomegranates that differed in varietal characteristics: colour (yellow, bicoloured, and red), shape (round, oval, and flattened), and calyx shape (open, semi-open, and closed). Colour was by far the most important factor for consumers, followed by fruit shape and calyx shape. Two preference profiles were identified. Most consumers liked bicolour and red pomegranates equally, and rejected yellow ones, while a smaller group concentrated their choice on bicolour pomegranates. In terms of fruit and calyx shape, oval and flattened fruit and open calyx were the most preferred by both consumer groups. Barriers and drivers for consumption were also investigated. There is still plenty of room to increase pomegranate consumption. Greater availability of pomegranates and ready-to-eat arils in grocery shops, obtaining new unseeded/easier-to-peel varieties, and providing a sensory label would help to overcome current barriers. Marketing campaigns should focus on a pomegranate’s health benefits and its versatility in consumption.
The Preparation and Properties of Amino-Carboxymethyl Chitosan-Based Antibacterial Hydrogel Loaded with ε-Polylysine
Authors: Li Yixi , Qiu Yulong , Hou Hongman , Zhang Gongliang , Hao Hongshun , Bi Jingran
Published: October 2023

In this paper, amino-carboxymethyl chitosan (ACC) was prepared through amino carboxymethylation, which introduces -COOH and -NH2 groups to the chitosan (CS) chains. Meanwhile, dialdehyde starch (DAS) was produced by oxidizing corn starch using sodium periodate. To attain the optimal loading and long-time release of ε-polylysine (ε-PL), the ACC/DAS hydrogels were synthesized through the Schiff base reaction between the amino group on ACC and the aldehyde group in DAS. The molecular structure, microcosmic properties, loading capacity, and bacteriostatic properties of the four types of hydrogels containing different mass concentrations of ACC were investigated. The results showed that the dynamic imine bond C=N existed in the ACC/DAS hydrogels, which proved that the hydrogels were formed by the cross-linking of the Schiff base reaction. With the increasing mass concentration of the ACC, the cross-sectional morphology of the hydrogel became smoother, the thermal stability increased, and the swelling behavior was gradually enhanced. The tight network structure improved the ε-PL loading efficiency, with the highest value of 99.2%. Moreover, the loading of ε-PL gave the hydrogel good antibacterial properties. These results indicate that ACC/DAS hydrogel is potential in food preservation.
Loss of the KN Motif and AnKyrin Repeat Domain 1 (KANK1) Leads to Lymphoid Compartment Dysregulation in Murine Model
Authors: Almosailleakh Marwa , Bentivegna Sofia , Narcisi Samuele , Benquet Sébasitien J. , Gillberg Linn , Montaño-Almendras Carmen P. , Savickas Simonas , Schoof Erwin M. , Wegener Amelie , Luche Hérve , Jensen Henrik E. , Côme Christophe , Grønbæk Kirsten
Published: October 2023

The KN Motif and AnKyrin Repeat Domain 1 (KANK1) is proposed as a tumour suppressor gene, as its expression is reduced or absent in several types of tumour tissue, and over-expressing the protein inhibited the proliferation of tumour cells in solid cancer models. We report a novel germline loss of heterozygosity mutation encompassing the KANK1 gene in a young patient diagnosed with myelodysplastic neoplasm (MDS) with no additional disease-related genomic aberrations. To study the potential role of KANK1 in haematopoiesis, we generated a new transgenic mouse model with a confirmed loss of KANK1 expression. KANK1 knockout mice did not develop any haematological abnormalities; however, the loss of its expression led to alteration in the colony forming and proliferative potential of bone marrow (BM) cells and a decrease in hematopoietic stem and progenitor cells (HSPCs) population frequency. A comprehensive marker expression analysis of lineage cell populations indicated a role for Kank1 in lymphoid cell development, and total protein analysis suggests the involvement of Kank1 in BM cells’ cytoskeleton formation and mobility.
Worlds of Meaning at the Edge of Extinction: Conservation Behaviour and the Environmental Humanities
Authors: van Dooren Thom
Published: October 2023

We are living in the midst of a period of mass extinction. All around us, diverse species of animals and plants are disappearing, often largely unnoticed. However, this is also a period in which, on a daily basis, new and fascinating insights into animal life are emerging as we come to appreciate more about their remarkable perceptual, cognitive, social, and emotional lives. This article explores this strange juxtaposition of loss and knowledge-making and the many challenges and possibilities that it gives rise to. It focuses on the emerging field of Conservation Behaviour in which researchers are seeking to modify or manipulate animal behaviours to achieve conservation outcomes: for example, teaching lizards not to eat toxic prey, or birds to utilise a safer migratory route. The article seeks to bring this approach to conservation into dialogue with work in environmental humanities, including the emerging paradigm of conservation humanities. The article outlines an interdisciplinary environmental humanities approach to conservation behaviour, grounded in work in multispecies studies and philosophical ethology. It then explores four broad thematic areas—agency, identity, ethics, and loss—in which the dialogue between these two fields might prove to be particularly, and mutually, enriching.
Timing of Early Cholecystectomy for Acute Calculous Cholecystitis: A Multicentric Prospective Observational Study
Authors: Fugazzola Paola , Abu-Zidan Fikri M. , Cobianchi Lorenzo , Dal Mas Francesca , Ceresoli Marco , Coccolini Federico , Frassini Simone , Tomasoni Matteo , Catena Fausto , Ansaloni Luca ,   on behalf of the S.P.Ri.M.A.C.C. Collaborative Group
Published: October 2023

The definition of Early Cholecystectomy (EC) is still debatable. This paper aims to find whether the timing of EC affects outcomes. The article reports a multicentric prospective observational study including patients with acute calculous cholecystitis (ACC) who had cholecystectomy within ten days from the onset of symptoms. Kruskall-Wallis test, Fisher’s Exact test, and Spearman rank correlation were used for statistical analysis. The patients were divided into three groups depending on the timing of the operation: 0–3 days, 4–7 days, or 8–10 days from the onset of symptoms. 1117 patients were studied over a year. The time from the onset of symptoms to EC did not affect the post-operative complications and mortality, the conversion, and the reintervention rate. The time represented a significant risk factor for intraoperative complications (0–3 days, 2.8%; 4–7 days, 5.6%; 8–10 days, 7.9%; p = 0.01) and subtotal cholecystectomies (0–3 days, 2.7%; 4–7 days, 5.6%; 8–10 days, 10.9%; p < 0.001). ACC is an evolutive inflammatory process and, as the days go by, the local and systemic inflammation increases, making surgery more complex and difficult with a higher risk of intraoperative complications. We recommend performing EC for ACC as soon as possible, within the first ten days of the onset of symptoms.
Reconciling a Broken Heritage: Developing Mental Health Social Work in Guyana
Authors: Halley Coya , Cowden Stephen
Published: October 2023

Guyana’s colonial past has left a trail of economic instability, racial polarization, and physical and mental trauma. Despite the progress made since Guyana’s independence in 1966, the remnants of this colonial past continue to shape present-day Guyana. As a result, violence and trauma continue to impact the mental health of the population. This is manifest in endemic problems of domestic violence and racialized social divisions which have created the conditions for rates of suicide which are amongst the highest in the world. The formal mental health provision which exists in Guyana is based primarily on an individualized and largely biomedical model of care. Despite valuable attempts to develop this provision, the difficulty of physically accessing this for some people and the stigma which surround this means that the capacity of this system to address the serious problems which exist is limited. It is also the case that in times of emotional and psychic distress, and in the context of Guyana being a very religious country, many people turn to traditional supernatural healers and remedies for support. In this paper, we discuss what is known as “Obeah”, noting that while this is widely practiced, it remains something of a taboo subject in Guyana. We consider the reasons why these practices and beliefs continue to be influential. However, what neither these biomedical or supernatural perceptions of mental health are able to address is the sociogenic nature of Guyana’s mental health issues, which we argue emerges out of the historic trauma of Guyana’s experience of colonialism and the violence which it engendered. We argue that profound forms of mental distress which exist in Guyana call for an integrative and holistic practice model that contextualizes these problems through a sociogenic lens. Social workers, working collaboratively with other health-related professions, can occupy a critical role in integrating these different conceptions through developing a rights-based model of mental health where the causes of mental ill-health are understood as socially determined.
Effects of Standing after a Meal on Glucose Metabolism and Energy Expenditure
Authors: Kono Hiroya , Furuta Kento , Sakamoto Takumi , Ueda Shin-ya
Published: October 2023

In the past decade, university students have become more sedentary. A sedentary lifestyle is associated with an increased risk of obesity and cardiovascular disease. Methods that decrease sedentary lifestyles, such as the use of standing desks to increase physical activity, have been extensively examined. However, the effects of postprandial standing and sitting on energy metabolism have not yet been compared. Therefore, the present study investigated the effects of standing after a meal on energy expenditure and glucose metabolism. Ten males participated in the present study. The experiment was initiated with 300 g of rice ingested as a carbohydrate load. The subjects maintained a standing or sitting position for 120 min after the meal. Energy expenditure was calculated from VO2 and VCO2 using the indirect calorimetry method. Glucose metabolism was assessed by measuring blood glucose levels and the exogenous glucose metabolic rate. Energy expenditure through standing after eating was approximately 0.16 ± 0.08 kcal/min higher than that through sitting. Blood glucose dynamics did not significantly differ between the standing and sitting positions. Furthermore, no significant differences were observed in the dynamics of the exogenous glucose metabolic rate between the standing and sitting positions. Standing for 2 h after a meal increased energy expenditure by 10.7 ± 4.6% without affecting glucose metabolism.
Histone Methyltransferases G9a/Ehmt2 and GLP/Ehmt1 Are Associated with Cell Viability and Poorer Prognosis in Neuroblastoma and Ewing Sarcoma
Authors: Souza Barbara Kunzler , Freire Natalia Hogetop , Monteiro Thiago Santos , Herlinger Alice Laschuk , Jaeger Mariane , Dalmolin Matheus G. S. , de Farias Caroline Brunetto , Gregianin Lauro , Brunetto André T. , Brunetto Algemir L. , Thiele Carol J. , Roesler Rafael
Published: October 2023

Changes in epigenetic programming have been proposed as being key events in the initiation and progression of childhood cancers. HMT euchromatic histone lysine methyltransferase 2 (G9a, EHMT2), which is encoded by the G9a (Ehmt2) gene, as well as its related protein GLP, which is encoded by the GLP/Ehmt1 gene, participate in epigenetic regulation by contributing to a transcriptionally repressed chromatin state. G9a/GLP activation has been reported in several cancer types. Herein, we evaluated the role of G9a in two solid pediatric tumors: neuroblastoma (NB) and Ewing sarcoma (ES). Our results show that G9a/Ehmt2 and GLP/Ehmt1 expression is higher in tumors with poorer prognosis, including St4 International Neuroblastoma Staging System (INSS) stage, MYCN amplified NB, and metastatic ES. Importantly, higher G9a and GLP levels were associated with shorter patient overall survival (OS) in both NB and ES. Moreover, pharmacological inhibition of G9a/GLP reduced cell viability in NB and ES cells. These findings suggest that G9a and GLP are associated with more aggressive NB and ES tumors and should be further investigated as being epigenetic targets in pediatric solid cancers.
Advances in Polyoxometalates as Electron Mediators for Photocatalytic Dye Degradation
Authors: Li Ruyue , Wang Yaqi , Zeng Fei , Si Cuiqing , Zhang Dan , Xu Wenbiao , Shi Junyou
Published: October 2023

The increasing concerns over the environment and the growing demand for sustainable water treatment technologies have sparked substantial interest in the field of photocatalytic dye removal. Polyoxometalates (POMs), known for their intricate metal–oxygen anion clusters, have received considerable attention due to their versatile structures, compositions, and efficient facilitation of photo-induced electron transfers. This paper provides an overview of the ongoing research progress in the realm of photocatalytic dye degradation utilizing POMs and their derivatives. The details encompass the compositions of catalysts, catalytic efficacy, and light absorption propensities, and the photocatalytic mechanisms inherent to POM-based materials for dye degradation are exhaustively expounded upon. This review not only contributes to a better understanding of the potential of POM-based materials in photocatalytic dye degradation, but also presents the advancements and future prospects in this domain of environmental remediation.
Poly(dA:dT) Tracts Differentially Modulate Nucleosome Remodeling Activity of RSC and ISW1a Complexes, Exerting Tract Orientation-Dependent and -Independent Effects
Authors: Amigo Roberto , Raiqueo Fernanda , Tarifeño Estefanía , Farkas Carlos , Gutiérrez José L.
Published: October 2023

The establishment and maintenance of nucleosome-free regions (NFRs) are prominent processes within chromatin dynamics. Transcription factors, ATP-dependent chromatin remodeling complexes (CRCs) and DNA sequences are the main factors involved. In Saccharomyces cerevisiae, CRCs such as RSC contribute to chromatin opening at NFRs, while other complexes, including ISW1a, contribute to NFR shrinking. Regarding DNA sequences, growing evidence points to poly(dA:dT) tracts as playing a direct role in active processes involved in nucleosome positioning dynamics. Intriguingly, poly(dA:dT)-tract-containing NFRs span asymmetrically relative to the location of the tract by a currently unknown mechanism. In order to obtain insight into the role of poly(dA:dT) tracts in nucleosome remodeling, we performed a systematic analysis of their influence on the activity of ISW1a and RSC complexes. Our results show that poly(dA:dT) tracts differentially affect the activity of these CRCs. Moreover, we found differences between the effects exerted by the two alternative tract orientations. Remarkably, tract-containing linker DNA is taken as exit DNA for nucleosome sliding catalyzed by RSC. Our findings show that defined DNA sequences, when present in linker DNA, can dictate in which direction a remodeling complex has to slide nucleosomes and shed light into the mechanisms underlying asymmetrical chromatin opening around poly(dA:dT) tracts.
Vascular Ultrasound for In Vivo Assessment of Arterial Pathologies in a Murine Model of Atherosclerosis and Aortic Aneurysm
Authors: Hof Alexander , Guthoff Henning , Ahdab Maysam , Landerer Max , Schäkel Jasper , Niehues Jana , Schorscher Maximilian , Zimmermann Oscar , Winkels Holger , von Stein Philipp , Geißen Simon , Baldus Stephan , Adam Matti , Mollenhauer Martin , Mehrkens Dennis
Published: October 2023

Vascular diseases like atherosclerosis and abdominal aortic aneurysm (AAA) are common pathologies in the western world, promoting various potentially fatal conditions. Here, we evaluate high-resolution (HR) ultrasound in mouse models of atherosclerosis and AAA as a useful tool for noninvasive monitoring of early vascular changes in vivo. We used Apolipoprotein E-deficient (ApoE−/−) mice as an atherosclerosis model and induced AAA development by the implementation of Angiotensin II-releasing osmotic minipumps. HR ultrasound of the carotid artery or the abdominal aorta was performed to monitor vascular remodeling in vivo. Images were analyzed by speckle tracking algorithms and correlated to histological analyses and subsequent automated collagen quantification. Consistent changes were observed via ultrasound in both models: Global radial strain (GRS) was notably reduced in the AAA model (23.8 ± 2.8% vs. 12.5 ± 2.5%, p = 0.01) and in the atherosclerotic mice (20.6 ± 1.3% vs. 15.8 ± 0.9%, p = 0.02). In mice with AAA, vessel distensibility was significantly reduced, whereas intima–media thickness was increased in atherosclerotic mice. The area and collagen content of the tunica media were increased in diseased arteries of both models as measured by automated image analysis of Picrosirius Red-stained aortic sections. Correlation analysis revealed a strong correlation of multiple parameters, predicting early vascular damage in HR ultrasound and histological examinations. In conclusion, our findings underscore the potential of HR ultrasound in effectively tracing early alterations in arterial wall properties in murine models of atherosclerosis and AAA.
Acute Phase Protein Orosomucoid (Alpha-1-Acid Glycoprotein) Predicts Delayed Cerebral Ischemia and 3-Month Unfavorable Outcome after Aneurysmal Subarachnoid Hemorrhage
Authors: Zavori Laszlo , Varnai Reka , Molnar Tihamer , Szirmay Balazs , Farkas Nelli , Schwarcz Attila , Csecsei Peter
Published: October 2023

The pathophysiology and consequences of early brain injury (EBI) after aneurysmal subarachnoid hemorrhage (aSAH) remain incompletely understood. This study aims to investigate the role of orosomucoid (ORM) in aSAH, its potential as a marker for assessing the extent of EBI-induced damage, and its correlation with delayed cerebral ischemia (DCI) and functional recovery over a 3-month period. We collected serum specimens 72 h post-aSAH to measure ORM levels. The study included 151 aSAH patients and 105 healthy subjects. The serum ORM levels within the patient cohort significantly exceeded those in the control group (p < 0.001). The ORM value showed significant correlation with the admission WFNS (p < 0.0001) and mFS scores (p < 0.05). Substantially elevated serum ORM levels at 72 h post-aSAH were detected among patients experiencing DCI, as well as those with poor functional outcomes after 3 months (p = 0.009 and p < 0.001). Binary logistic regression analyses revealed that serum ORM at 72 h post-SAH was independently associated with DCI and 3-month functional outcome after adjusting for confounders. The early stage events of aSAH influence the level of ORM. ORM serves as a marker for assessing the extent of damage during EBI and is linked to the occurrence of DCI as well as unfavorable long-term functional outcomes.
The Impact of the War in Ukraine on the Epidemiological Situation of Tuberculosis in Europe
Authors: Wilczek Natalia Anna , Brzyska Anna , Bogucka Julia , Sielwanowska Wiktoria Ewa , Żybowska Monika , Piecewicz-Szczęsna Halina , Smoleń Agata
Published: October 2023

Ukraine is at the forefront of one of the largest outbreaks of tuberculosis (TB) in Europe, including multidrug-resistant tuberculosis. Due to the ongoing armed conflict in this area, there is a significant number of refugees from Ukraine to other European countries. The aim of the study is to emphasize the essence of the problem of the increased incidence of tuberculosis, taking into account the impact of the armed conflict in Ukraine, resulting in the intensification of migration movements. A descriptive epidemiological method was used as the research method. The material was collected by analyzing source statistical data from WHO and statistical yearbooks of selected European countries. Particularly, Ukrainian refugees in Poland, Germany, the Czech Republic, and Slovakia are at higher risk of contracting tuberculosis due to factors like migration stress, poor nutrition, and comorbidities. Epidemiological data from these countries show a rise in tuberculosis cases among foreigners, emphasizing the need for European specialists to be more vigilant in this unique situation, focusing on refugees and other vulnerable populations. More research and collaborative efforts are essential to closely monitor and prevent the severe outcomes of tuberculosis transmission.
Blood-Based Biomarkers in Intracerebral Hemorrhage
Authors: Lv Xin-Ni , Li Zuo-Qiao , Li Qi
Published: October 2023

Intracerebral hemorrhage (ICH) is one of the most lethal subtypes of stroke, associated with high morbidity and mortality. Prevention of hematoma growth and perihematomal edema expansion are promising therapeutic targets currently under investigation. Despite recent improvements in the management of ICH, the ideal treatments are still to be determined. Early stratification and triage of ICH patients enable the adjustment of the standard of care in keeping with the personalized medicine principles. In recent years, research efforts have been concentrated on the development and validation of blood-based biomarkers. The benefit of looking for blood candidate markers is obvious because of their acceptance in terms of sample collection by the general population compared to any other body fluid. Given their ease of accessibility in clinical practice, blood-based biomarkers have been widely used as potential diagnostic, predictive, and prognostic markers. This review identifies some relevant and potentially promising blood biomarkers for ICH. These blood-based markers are summarized by their roles in clinical practice. Well-designed and large-scale studies are required to validate the use of all these biomarkers in the future.
Suicide among Cancer Patients: Current Knowledge and Directions for Observational Research
Authors: Grobman Ben , Mansur Arian , Babalola Dolapo , Srinivasan Anirudh P. , Antonio Jose Marco , Lu Christine Y.
Published: October 2023

Cancer is a major public health concern associated with an increased risk of psychosocial distress and suicide. The reasons for this increased risk are still being characterized. The purpose of this study is to highlight existing observational studies on cancer-related suicides in the United States and identify gaps for future research. This work helps inform clinical and policy decision-making on suicide prevention interventions and ongoing research on the detection and quantification of suicide risk among cancer patients. We identified 73 peer-reviewed studies (2010–2022) that examined the intersection of cancer and suicide using searches of PubMed and Embase. Overall, the reviewed studies showed that cancer patients have an elevated risk of suicide when compared to the general population. In general, the risk was higher among White, male, and older cancer patients, as well as among patients living in rural areas and with lower socioeconomic status. Future studies should further investigate the psychosocial aspects of receiving a diagnosis of cancer on patients’ mental health as well as the impact of new treatments and their availability on suicide risk and disparities among cancer patients to better inform policies.
Normothermic Ex Situ Machine Perfusion of Vascularized Composite Allografts with Oxygen Microcarriers for 12 Hours Using Real-Time Mitochondrial Redox Quantification
Authors: Haug Valentin , Peng Yifeng , Tchiloemba Bianief , Wang Alice T. , Buerger Florian , Romfh Padraic , Kneser Ulrich , Polizzotti Brian D. , Pomahac Bohdan
Published: October 2023

Background: Normothermic ex situ perfusion of vascularized composite allografts (VCAs) necessitates high oxygen demand and, thus, increased metabolic activity, which, in turn, requires the use of blood-based perfusion solutions. However, blood-derived perfusates, in turn, constitute an antigenic load. To circumvent this immunogenic problem, we used a perfusate enriched with acellular dextrane oxygen microcarriers to perfuse rat hindlimbs. Methods: Rat hindlimbs (n = 11) were perfused with either (non-), oxygenated dextrane-enriched Phoxilium, or Phoxilium enriched with dextrane oxygen microcarriers (MO2) for 12 h at 37 °C or stored on ice. Oxygenation of the skeletal muscle was assessed with Raman spectroscopy, tissue pO2-probes, and analysis of the perfusate. Transmission electronic microscopy was utilized to assess the ultrastructure of mitochondria of the skeletal muscle. Results: For all evaluated conditions, ischemia time until perfusion was comparable (22.91 ± 1.64 min; p = 0.1559). After 12 h, limb weight increased significantly by at least 81%, up to 124% in the perfusion groups, and by 27% in the static cold storage (SCS) group. Raman spectroscopy signals of skeletal muscle did not differ substantially among the groups during either perfusion or static cold storage across the duration of the experiment. While the total number of skeletal muscle mitochondria decreased significantly compared to baseline, mitochondrial diameter increased in the perfusion groups and the static cold storage group. Conclusion: The use of oxygen microcarriers in ex situ perfusion of VCA with acellular perfusates under normothermic conditions for 12 h facilitates the maintenance of mitochondrial structure, as well as a subsequent recovery of mitochondrial redox status over time, while markers of muscle injury were lower compared to conventional oxygenated acellular perfusates.
Impact Testing and Modelling of Composite Laminate Panels for Use in Off-Road Racing Vehicle Belly Guards
Authors: Brinkmann Tim , Bester Christiaan R.
Published: October 2023

Off-road racing vehicles require protection on the underside of their chassis in order to protect vital components from impact damage. The use of composites in thin laminate form to achieve this protection is widespread, although failure due to impact from foreign objects still occurs. The use of UHMWPE (Ultra High-Molecular Weight Polyethylene) fibres, which have superior mechanical properties to aramid fibres in vehicle belly guards, is not prevalent and, hence, could prove useful in this application. A comprehensive Finite Element Analysis (FEA) is performed in order to determine suitable laminate panel layups that can be tested, analysed, and compared to the original laminate layup, which comprises six layers of aramid and two layers of carbon fibre fabrics. This provides initial insight into the comparison of the new proposed laminates and reveals if improvements have been made. The laminates found using FEA are manufactured into panels that represent the fixture and loading cases seen in racing vehicles. Experimental testing is carried out on the various panels, and the results are compared to those of the mathematical modelling. Substituting the currently used carbon fibres with more aramid fibres increases the impact resistance of the panel. Using UHMWPE fibres greatly increases the impact resistance of the panel; however, fibre delamination becomes more prevalent. This is due to the poor fibre wettability of UHMWPE fibres and the large strain before failure of the fibres. The modelled results show good agreement with the experimental results in terms of the locations at which damage occurred.
Can Online Consumer Reviews Identify Key Evidence Regarding Common Consumer Choices for High-Tech Pet Products?
Authors: Nguyen Huyen Ngoc , Yoo Donghee
Published: October 2023

Online consumer reviews (OCRs) significantly influence consumer purchase decisions for new products. Therefore, today’s companies actively seek practical approaches for analyzing these OCRs. This study proposes a comprehensive method for OCR analysis using topic modeling and association rule analysis to overcome the current limitations in topic interpretation and topic overlap in text mining. Meanwhile, to examine the development of the high-tech industry and customer interest in the pet care field, this study synthesizes and analyzes reviews from consumers who are using healthcare products in the pet industry. To this end, we first collected 20,820 customer reviews from Amazon.com (accessed on 2 August 2023) for high-tech pet products and categorized them into three distinct product categories. Topic modeling was then conducted on each category, revealing five key topics per category. Subsequently, association rules analysis was performed on the customer reviews associated with the most representative topic. As a result, we were able to demonstrate that ‘satisfaction’ emerged as the most crucial topic across all three categories of high-tech pet products. Satisfaction is a topic expressing consumers’ attitudes after experiencing the product, and they used words to describe their feelings in the product reviews. A diverse range of associated terms was also identified that represented the essence of each product’s corresponding representative explanations. By leveraging these approaches, we are confident that pet product companies and market players will gain valuable insights into consumer preferences and behavior.
User-Informed Adaptation in IoT Home Healthcare: Grounding Development in Empirical Evidence
Authors: Fehringer Hannah , Stary Christian
Published: October 2023

IoT (Internet of Things)-enabled products are increasingly used by consumers and continuously propagate in daily life. Billions of networked objects not only increase the complexity of development but also raise user interaction and adaptation to individual needs. The more non-expert users are involved in decision making, interaction, and adaptation processes, the more user-centric IoT design is crucial, particularly when the number of elderly users is steadily increasing. In this paper, we study the capabilities of adopting IoT products through user-informed adaptation in a major IoT application domain, home healthcare. We review evidence from established practice in the field on how users can be supported when aiming to adapt medical IoT (M-IoT) home applications to their needs. We examine the empirically grounded use of IoT sensors and actuators, as well as the adaptation process users adopt when using an IoT application in a personalized environment. Our analysis (technological evidence) reveals various IoT devices that have already been applied in M-IoT adaptation settings to effectively support users. Our analysis reveals that only few empirically sound findings exist on how users actually perceive interactive adaptation features and redesign M-IoT applications. Based on the analysis of these empirically grounded findings, we suggest the development of a domain-specific user-centric adaptation feature. Specifically, we exemplify a tangible adaptation device for user-informed M-IoT application in home healthcare. It has been developed prototypically and tested in an environment for personalized home healthcare.
How Should Soundscape Optimization from Perceived Soundscape Elements in Urban Forests by the Riverside Be Performed?
Authors: Hong Xin-Chen , Cheng Shi , Liu Jiang , Guo Lian-Huan , Dang Emily , Wang Jia-Bing , Cheng Yuning
Published: October 2023

Urban forests by the riverside are important habitats for various animals and contribute various soundscapes for citizens. Unfortunately, urban forests are exposed to the influence of riverside traffic noises from freeways. This study aims to explore the spatial and temporal variation of soundscape, conduct soundscape optimization for multiple parameters, and find a balance and its interval of soundscape elements through optimizing a soundscape map. Questionnaires and measuring equipment were used to gather soundscape information in an urban forested area in Fuzhou, China. Diurnal variations and soundscape mapping were used to analyze spatial and psychophysical relationships between soundscape drivers. We then conducted optimization for a soundscape map, which included normalization, critical value determination, target interval of optimal SPL determination, and modification of SPL and mapping. Our findings suggest that biological activities and natural phenomena are potential drivers for diurnal variation of soundscapes, especially tidal phenomena contributing water and shipping soundscapes. Our results also suggest that all the high values of perceived soundscapes were found at the southwest corner of the study area, which includes both riverside and urban forest elements. Furthermore, we suggest combining both optimal soundscape and SPL correction maps to aid in sustainable design in urban forests. This can contribute to the understanding and methodology of soundscape map optimization in urban forests when proposing suitable design plans and conservation of territorial sound.
Impacts of Land Urbanization on CO2 Emissions: Policy Implications Based on Developmental Stages
Authors: Xiao Yi , Liao Yuantao , Li Zhe , Li Zhuojun , Wang Shaojian
Published: October 2023

The systematic advancement of land urbanization coupled with the pursuit of a low-carbon economy constitutes a critical challenge faced by numerous nations across the globe. Utilizing panel data spanning 195 countries from 1990 to 2020, this study employed a panel regression model to scrutinize the impact mechanisms of land urbanization on CO2 emissions across income groups. The findings revealed a consistent overall increase in both land urbanization and per capita CO2 emissions during the period examined, with marked disparities evident among countries of varying income levels. The regression analysis further identified an “inverted U-shaped” curve relationship between land urbanization and per capita CO2 emissions in the global context and within high-income panels. Conversely, a “U-shaped” curve relationship was discerned in lower-middle-income nations, whereas a linear relationship was observed in upper-middle-income and low-income countries. These insights serve to deepen the understanding of the CO2 emission implications of land urbanization across countries at different development stages. This study underscores the necessity for countries to attentively consider their unique stage of development when devising CO2 reduction policies, reinforcing the complex interplay between urbanization, economic categorization, and environmental stewardship.
High-Temperature Wear and Frictional Performance of Plasma-Nitrided AISI H13 Die Steel
Authors: Kumar Ashish , Kaur Manpreet , Joseph Alphonsa , Jhala Ghanshyam , Nanda Tarun , Singh Surinder
Published: October 2023

Plasma nitriding, a surface treatment technique, is gaining popularity, as it is environment-friendly and offers superior mechanical properties. This research studied the wear and friction performance of AISI H13 die steel after plasma nitriding in a gas mixture of N2:H2 at 20:80, 50:50, and 80:20 (volume ratio) at a fixed time and temperature. This work aimed to analyze the sliding wear performance of the plasma-nitrided tool die steel in hot-forming operations at higher loads. Scanning electron microscopy/electron-dispersive spectroscopy (SEM/EDS) and X-ray diffraction (XRD) techniques were used to study the microstructures of the H13 die steel pins after plasma nitriding. Wear tests were performed on a high-temperature tribometer under uni-directional sliding and dry conditions using a high-temperature tribometer under a 50 N load at various operating temperatures ranging from 25 °C to 600 °C. The results show that the plasma-nitriding process with N2:H2 at 20:80 improved the wear behavior of H13 steel. The friction coefficients and wear volume losses for all the plasma-nitrided specimens were less than those of the untreated die steel.