bluuebunny/crossref_metadata_2025 huggingface dataset:
Correlation between Clinical, Operative and Histopathological Findings of Adnexal Masses – A Study of 50 Cases
Authors: Rahman Dilara , Jahan Afia Akhter , Akter Asma , Parvin Mossammat Tahmina , Mile Jasrin Akter , Rouf Salma
Published: June 2023

Background: Adnexal mass has multidimensional diagnosis that may be related to fallopian tube, ovary etc. These masses may be benign, intermediate and malignant. The ability of clinical approach to diagnose the exact pathology of adnexal mass is still a question.

Objective: To explore the correlation of clinical findings with operative and histopathological findings of adnexal masses.

Method and Materials: A prospective and observational study was conducted in a tertiary hospital during the period of July 2015 to December 2015. 69 patients were selected according to purposive sampling and further scrutinized according to selection criteria, which were clinically diagnosed as adnexal mass. All the 50 patients undergone surgical intervention followed by histopathology. All the patients’ data were recorded through a semi-structured data collection sheet.

Result: Study shows clinical and post-operative (per-operative + histopathology) findings of adnexal masses were 54% vs 50% for ovarian endometrioma, 24% vs 22% for benign ovarian tumor and 22% vs 26% for other adnexal masses respectively.

Conclusion: Clinical findings with the help of sonography can guide effectively to the diagnosis of adnexal masses. However, per-operative and histopathological findings are required for the confirmation.

Central Medical College Journal Vol 6 No 2 Jauly 2022 Page: 62-66
Pattern and seasonal variations of snake bite in southern part of Bangladesh
Authors: Uddin Mohammad Nazim , Ghose Aniruddha , Majumder Md Mahabubul Islam , Akter Raushan , Ali Mohammad Moharam , Ahmed Mostaque
Published: June 2023

Background: Snake bite is one of the leading causes of mortality and morbidity in many regions, notably the rural tropics, and is a globally overlooked occurrence. Present study is aimed to find the pattern and seasonal variations of snakebite in the southern part of Bangladesh.

Methods: A one-year retrospective survey was done on 554 venomous or non-venomous snake bite patients admitting in a tertiary care hospital Chittagong Medical College Hospital, Bangladesh. Through the administration of a questionnaire, data on snake bites and kinds, date and time of bite and envenomation characteristics were obtained from respondents over a twelve-month period. After data collection, SPSS-20 was utilized for analysis.

Results: In the present study male (64.1%) were found more affected than female and the vast majority of snake bite victims are younger Regarding pattern of envenomation, 400(72.2%) patients had no features of envenomation, 37(6.7%) local envenomation with spontaneous bleeding, 35(6.3%) had systemic envenomation, 74(13.4%) had local envenomation and 8(1.4%) had local swelling with neurotoxicity. Most of the patients were male (64.1%), female was mostly housewives (24.9%) and 68.1% were from poor socioeconomic status. Regarding monthly distribution of study patients where most patients were found during May to September and venomous bite were also more common during the month of May to August. Analysis of species of snakes revealed 89(16.1%) were pit viper, 87(15.7%) were dora snake, 23(4.2%) were cobra and 355(64.1%) snake bite were remained unidentified.

Conclusions: During the monsoon season (May to September) in Bangladesh, the incidence of both nonvenomous and venomous snake bites is much high and poisonous snake bites are prevalent during this time. Poor access to health services and superstition regarding dealing with Ozahs are also a common finding in our study.

Central Medical College Journal Vol 6 No 2 Jauly 2022 Page: 71-76
Tüketici Yeşil Yıkama Algısının Yeşil Marka Denkliğine Etkisi: Yeşil Algılanan Risk ve Yeşil Kafa Karışıklığının Aracılık Rolü
Authors: AKDOĞAN Çağatay , YILMAZTÜRK Yasin
Published: June 2023

Aşırı üretim doğal kaynakların azalmasına ve ekolojinin bozulmasına neden olmaktadır. Bu tahribatın ortadan kaldırılmasına yönelik uygulamalar, ürünün tüm kullanım süresi boyunca çevresel etkisi en aza indirilen “yeşil ürün” kavramını ortaya çıkarmaktadır. Pek çok marka/ürün, kendilerinin “yeşil” olduğunu iddia eden iletişim mesajlarını kullanmaktadır. Bu durum, işletmelerin çevresel uygulamaları ya da ürünün çevresel faydaları konusunda tüketicileri yanıltması olarak ifade edilen “yeşil yıkama” kavramının ortaya çıkmasına neden olmuştur. Bu gelişmeler, tüketicilerin “gerçek yeşil ürünler” ile “yeşil görünen ürünler” arasında kafa karışıklığı yaşamasına sebebiyet vermektedir. Bu kapsamda araştırmada, tüketicilerin yeşil yıkama algısının yeşil marka denkliği üzerindeki etkisinin incelenmesi, ayrıca bu etkide yeşil algılanan risk ve yeşil kafa karışıklığının aracılık rolünün belirlenmesi amaçlanmaktadır. Bu amaç doğrultusunda yeşil ürün satın almış olan tüketicilerden oluşan örneklem grubundan kolayda örnekleme yöntemi kullanılarak çevrimiçi anket yöntemiyle 547 veri elde edilmiştir. Ankette tüketicilere ait demografik sorular ve yeşil ürün tercihleriyle ilgili sorular bulunmaktadır. Bunun yanında, tüketicilerin yeşil yıkama algısını (YYA), yeşil algılanan riskini (YAR), yeşil kafa karışıklığını (YKK) ve yeşil marka denkliğini (YMD) değerlendirebilecek ölçeklerden yararlanılmıştır. Veriler SPSS 24 ve MPLUS8 programları ile analiz edilmiştir. Araştırma sonucunda YYA’nın YAR, YKK ve YMD üzerinde anlamlı etkisi olduğu, YYA’nın YMD üzerindeki etkisinde YKK’nın aracılık rolünün olduğu görülmektedir.
Relationship of Work Benefits and Incentives in Employee Productivity and Satisfaction Among BPO Workers in Manila in the Time of Pandemic
Authors: Santos Jason
Published: June 2023

This study was conducted in 2022 amongst BPO workers in the pandemic era. The main objective of this study is to identify the relationship between current work benefits and incentives to employees’ productivity and satisfaction. Quantitative Descriptive research method was used to analyze the satisfaction of the employees on the availability of work benefits and incentives and how it relates to their productivity and satisfaction. 200 BPO workers from Metro Manila and Bulacan participated in this study. A three component questionnaire was used to collect demographic information, satisfaction among work benefits and incentives and productivity and satisfaction of the employees. Findings show cash and medical benefits to be highly satisfying incentives among the employees. Another significant finding was the employees’ overall satisfaction with the support given by companies through equipment supply. The researcher used Pearson Correlational Analysis through SPSS version 27 and yielded a moderate positive relationship result. The researcher recommends emphasis and reinforcement of the identified, strong incentives driving employees’ productivity as well as support from both private and public sector in the enhancement of such benefits.
The Effect of Reward Programmes on Employees’ Performance in Ghana: Evidence from Kpone-Katamanso Municipal Assembly
Authors: ZAAPAYIM ABDUL JALIL MAHAMA ALHASSAN
Published: June 2023

The research investigated the influence of reward programs on employee performance in the context of the Kpone-Katamanso Municipal Assembly. Supported by the Expectancy Theory and the Goal Setting Theory as philosophical views on which the study is grounded, 10 employees from the Kpone-Katamanso Municipal Assembly made up the study population, and were chosen using standard random sampling procedures as the study mainly followed the qualitative paradigm besides demographics of respondents that were determined quantitatively using Statistical Package for Social Sciences (SPSS). This was used to calculate the ages, educational background, and number of years in the Assembly appropriately. Empirical outcomes of the study reveal that the primary means of rewarding employees is compensation. Word-of-mouth accolades, meeting allowances, gift packages, cash, and external training were also considered. The study also revealed that positive attitudes regarding employment are boosted by rewards. The practical implications encountered by the KKMA in compensating its employees according to the investigation were also deliberated.
Arabic Ontology: Linguistic Engineering Foundations
Authors: Boulaalam Ali , El Hannach Nisrine
Published: June 2023

This scientific intervention aims to raise the issue of the automatic processing of natural languages. Especially at its levels related to ontological studies, enabling the machine to recognize information and invest it accurately, beyond the constraints of semantic ambiguity is considered a scientific challenge. This would not be possible without relying on the contextual detection process of linguistic engineering, which is based on a hybrid approach that combines both statistical and linguistic methods. It is an approach that falls within the context of platform linguistics, or what is termed "fourth-generation linguistics", a natural outgrowth of the digital revolution, based on its horizontal extension in various domains and fields of knowledge, thus establishing a new indicative model in which platforms with linguistic and computer interact. In this context, the associative aspects within the compositional linguistic perceptions are a focal point in operating research operations that fall within the automatic processing of natural language, given the nature of its theoretical and methodological architecture with an empirical inductive basis. It also enables the building of computer platforms by preparing morphological, synthetic, semantic, and pragmatic analyzers. Investing in the advanced technological tools provided by the artificial intelligence system; especially in its aspects related to machine learning, deep learning, and neural network; will enable the provision of a linguistic platform capable of developing paths of teaching the Arabic language to non-native speakers.
Developing a Virtual Engineering Lab Using ADDIE Model
Authors: Amish Mohamed , Jihan Sha
Published: June 2023

In recent years, digital competence has become essential at the workplace. There is a growing demand for engineers with both employability and digital skills. As a result of the technological advancements, the Virtual Laboratory (VLab) concept was created to provide students with a safe environment to acquire the skills and enthusiasm to enhance the delivery of STEM (Science, Technology, Engineering, and Mathematics) subjects. This study presents a VLab developed using ADDIE model design criteria that allows users to perform VLab in engineering education. Users were able to carry out experiments individually or collectively, creating an effective, flexible learning environment for students. This was integrated smoothly into the Campus Moodle platform learning environment. The VLab design and implementation details are explained and validated through Alpha and Beta acceptance testing. A mixed-methods research design was used to collect and analyse the data. Questionnaires were used to collect quantitative data from 144 students, and 17 of them were interviewed to collect qualitative data. The findings revealed that the VLab is a collaborative, effective, and interactive learning environment that develops graduates' knowledge, soft skills, and digital skills while also improving their competencies relevant to the enhancement of digital skills at their workplace. As a result, lecturers are recommended to use VLab to enhance the quality of teaching and advance the learning experiences of their students.
MAHREM ALANDA SİVİL HUKUK İNŞASI: MAHMUT ESAT BOZKURT’UN MEDENİ KANUN GEREKÇESİ VE EUGEN HUBER KAYNAKÇASI
Authors: DUMANLI Çiğdem
Published: June 2023

Cumhuriyet’in ilanından sonra bir dizi inkılâp gerçekleştiren kadrolar, bu bağlamda o ana kadar mevcut olan Mecelle yerine doğrudan devletin çekirdeği, aileyi ilgilendiren hukuki meselelerde de bir dönüşüm öngörmüşlerdir. Buna yönelik çalışmalar 1924 yılında başlamış, 1926 yılında İsviçre Medeni Kanunu örneğinde Türk Kanunu Medenisi’ni resepsiyon yöntemiyle kabul etmişlerdir.

Bu Kanun, Osmanlı döneminde Mecelle’nin düzenlemeye dâhil etmediği, kişi, aile ve miras hukukunu da kapsayacak bir temel oluşturmuş ve o ana kadar mahrem olan alanda sivil bir hukuk anlayışını ortaya koymuştur. Şüphesiz Medeni Kanun o günden bu güne birçok çalışmaya konu olmuştur. Hristiyan-Batı’dan alınma bir kanunun Müslüman-Doğu coğrafyasından bir ülke ve toplumda uygulanabilirliği, bunda ne kadar başarılı olunabileceği, eksiklikleri ve doğruları ile 1926 Medeni Kanunu günümüz tartışmalarında da güncelliğini korumaktadır.

Bu makalede, Osmanlı döneminde Mecelle’nin ortaya koyduğu sorunlara, yeni Kanun’un Meclise taşınma sürecine, Meclise geldiği noktada dile getirilen görüşlere değinilecektir. Bununla birlikte, bilhassa Adalet Vekili Mahmut Esat (Bozkurt)’un Kanun’a sunduğu gerekçe irdelenecektir. Söz konusu gerekçe, İsviçre Federal Arşivi (Schweizerisches Bundesarchiv) evrakları içerisinde bulunan, Eugen Huber’in bir seçki olarak sunduğu ve o dönem İsviçre’de mevcut hukuk sorunlarına ilişkin bilgiler ihtiva eden kaynakça ile karşılaştırılacaktır. Bu bağlamda hem dönemin hem günümüzün birincil kaynakları ve ikincil literatürü çalışmaya dahil edilecektir.
Çocukların Cinsel İstismarı Suçu
Authors: ERGÜNE Elif
Published: June 2023

Çocukların cinsel istismarı suçu, Türk Ceza Kanunu’nun “cinsel dokunulmazlığa karşı suçlar” başlıklı bölümünde 103. maddede düzenlenmektedir. Çalışmada öncelikle bu suç ile korunan hukuksal değer ardından suçun unsurları analiz edilmiş ve bu çerçevede maddi unsurlar, manevi unsurlar ve hukuka aykırılık unsuru öğretideki tartışmalar ve yargı kararları ile birlikte incelenmiştir. Bundan sonra cinsel davranışın sarkıntılık düzeyinde kalması ve suçun vücuda organ veya sair cisim sokmak suretiyle işlenmesi ve diğer nitelikli unsurlarına değinilmiş, daha sonra kusurluluk ile ilgili önem arz eden hususlar irdelenmiştir. Ardından suçun temel ve nitelikli unsurlarına teşebbüs ve gönüllü vazgeçme, iştirak ve içtima konularına yer verilmiştir. Son olarak yaptırım, muhakeme, dava zamanaşımı ve infaza ilişkin özellik arz eden hususlar değerlendirme konusu yapılmıştır. Cinsel istismar suçuna ilişkin belirtilen bu hususlar doktrindeki tartışmalar ve yargı kararları ışığında, Alman hukukundaki benzer düzenlemelere değinilerek incelenmiştir.
Relação entre bruxismo e desordens temporomandibulares em pacientes com transtornos psiquiátricos: uma revisão sistemática da literatura
Authors: Rodrigues Guilherme Bastos , Borba Júlia Gabriela Melo
Published: June 2023

O seguinte artigo científico explora a relação entre bruxismo, disfunção temporomandibular (DTM) e distúrbios como depressão e ansiedade. O objetivo deste trabalho foi determinar a prevalência de DTM em pacientes com doenças psiquiátricas e investigar o impacto desses distúrbios na saúde bucal e no prognóstico desses problemas. Para isso, foram revisados vários estudos que examinaram essa relação, fornecendo resultados conflitantes em suas conclusões.
Embora alguns estudos tenham encontrado uma associação entre transtornos psiquiátricos e bruxismo/DTM, outros não encontraram uma associação significativa. Os fatores psicológicos podem ter influência nas duas doenças, mas os resultados variam dependendo do estudo analisado. Portanto, a relação entre essas condições é complexa e requer mais investigações para uma compreensão completa. A elaboração de protocolos de tratamento dessas enfermidades deve envolver profissionais multiprofissionais, como dentistas, médicos e psicólogos, a fim de abordar os aspectos físicos e psicológicos envolvidos. Essa abordagem integrada pode ajudar a melhorar o prognóstico e o bem-estar dos pacientes que enfrentam esses problemas em conjunto. É importante ressaltar que são necessárias mais pesquisas para esclarecer a relação entre bruxismo, DTM e transtornos psiquiátricos, bem como para desenvolver intervenções eficazes e personalizadas. Portanto, futuros estudos nessa área são essenciais para orientar o tratamento e fornecer melhores alternativas terapêuticas.
Manejo nutricional no tratamento da síndrome do intestino irritável (SII)
Authors: Tsui Wendy , Santos Geovana Chagas dos , Almeida Simone Gonçalves de
Published: June 2023

O estilo de vida e padrões alimentares ocidentais têm contribuído para o aumento da incidência de doenças gastrointestinais na população. A alimentação padrão ocidental é caracterizada pelos ultraprocessados, alimentos estes que possuem perfil pró-inflamatório e que favorecem o desequilíbrio da microbiota intestinal. Dos principais distúrbios gastrointestinais, destaca-se a síndrome do intestino irritável (SII), distúrbio intestinal crônico que já atinge uma parcela expressiva da população e cujo principais sintomas são as dores e os desconfortos abdominais. O presente estudo tem como objetivo principal analisar as principais estratégias nutricionais citadas na literatura para o tratamento e manejo de sintomas da SII, por meio de uma revisão integrativa da literatura. Foram coletados e avaliados os principais artigos sobre o tema publicados nos anos de 2018 a 2023, e, as informações encontradas na leitura, sintetizadas no presente estudo. Diante das informações coletadas, a dieta com baixo teor de FODMAPs tem se mostrado como a abordagem mais eficaz para tratamento dos sintomas gastrointestinais da SII, reduzindo a gravidade da doença e melhorando os sintomas de dor abdominal, inchaço e diarreia em pacientes. Enfatiza-se que a dieta deve ser conduzida por um nutricionista especializado para implementação adequada do protocolo, levando-se em consideração as individualidades de cada paciente. A SII não é uma síndrome que deve ser tratada de forma isolada, por não ser desencadeada de forma alimentar unicamente, é necessário um tratamento multidisciplinar.
Obesidade e diabetes infantis como agravantes dos quadros de COVID-19 em crianças no Oeste do Paraná
Authors: Souza Natália Godoi de , Fiori Carmem Maria Costa Mendonça
Published: June 2023

A COVID-19, uma doença respiratória causada pelo coronavírus SARS-CoV-2, tem sido uma preocupação global devido à sua propagação e impacto na saúde pública. O vírus se espalha principalmente por gotículas respiratórias, quando uma pessoa infectada tosse, espirra ou fala, mas também pode ser adquirido através do contato com superfícies contaminadas. Quando no organismo humano, adentra os pulmões através da enzima ECA2. O presente estudo teve como objetivo investigar se há uma maior incidência de casos graves de COVID-19 em crianças obesas e/ou diabéticas em comparação com crianças saudáveis. Para isso, foi conduzido um estudo quantitativo, observacional e transversal utilizando dados fornecidos pela Divisão de Vigilância Epidemiológica de Cascavel, envolvendo pacientes pediátricos de até 12 anos. Os resultados da análise dos casos de COVID-19 em crianças revelaram que a incidência de casos graves foi significativamente maior naquelas com diabetes e/ou obesidade. Essa descoberta sugere uma associação entre obesidade/diabetes e maior gravidade da infecção por COVID-19 em crianças e tais achados têm implicações importantes para a saúde pública e destacam a necessidade de políticas e intervenções específicas para prevenir e tratar a obesidade e o diabetes infantis. Além disso, ressaltam a importância de medidas preventivas, como a vacinação, para proteger as crianças contra a COVID-19 e reduzir o risco de complicações graves.
A importância da nutrição integrativa em pacientes com doenças autoimunes
Authors: Damasceno Silvana Martins Ferreira , Fernandes Renata de Almeida Silva , Almeida Simone Gonçalves de
Published: June 2023

Nos dias atuais, o comprometimento do sistema imune vem sendo discutido e teorizado com o aumento significativo das doenças autoimunes. Estas, apresentam causas multifatoriais, podendo ser advindas de aptidão genética, exposição a xenobióticos, altos níveis de estresse, agentes infecciosos, má qualidade do sono, uso de drogas e/ou álcool, dependência do tabaco. Ocorrendo o desencadeamento da doença por um ou a combinação de mais fatores. Diante disso, o objetivo do trabalho foi compreender a importância da nutrição integrativa em pacientes com doenças autoimunes, a partir de uma pesquisa bibliográfica em bases científicas como Pubmed, ScieLO, EBSCO e CAPES, considerando artigos publicados entre 2012 e 2023, nas línguas portuguesa e inglesa, sendo excluídos aqueles que não se adequaram ao tema proposto e os estudos com animais. O estudo procurou relacionar os múltiplos fatores que causam agravo ou remissão da doença no indivíduo, bem como suas inúmeras causas de irritação, com medidas de intervenções nutricionais que reduzem a inflamação, apoiam o sistema imunológico e restauram o equilíbrio da saúde do paciente para um melhor bem-estar. Verificou-se que o paciente com doença autoimune requer tratamento de forma global, onde os profissionais estejam atentos a sua totalidade. Os cuidados precisam ir além de drogas para o controle da doença, afinal, alinhar mente e corpo é imprescindível para a remissão da doença, uma vez que a sua manifestação envolve mais que genética e inflamação.
Panorama das pesquisas sobre monitoramento da qualidade do ar com a utilização de biomonitores
Authors: Lima Rubem Alves de , Araújo Elidianne Layanne Medeiros de
Published: June 2023

O presente estudo tem como objetivo revisar a literatura que trata do emprego de biomonitores para avaliação da qualidade do ar, no Brasil. Utilizou-se como método a revisão integrativa que investigou a produção do conhecimento sobre o tema. Para isso, recorreu-se às bases de dados Google Acadêmico, SciELO e Biblioteca Digital Brasileira de Teses e Dissertações (BDTD), estabelecendo como recorte temporal o período entre 2019 e 2022. Os termos de busca utilizados foram “biomonitoramento”, “biomonitor” e “bioindicador” para maior abrangência do tema e retorno de resultados mais representativos. Foram identificados 68 estudos brasileiros que preencheram os critérios iniciais de inclusão. Em seguida, os trabalhos passaram por 3 fases de filtragem, tendo como elementos de análise: (i) os títulos, (ii) os resumos e conclusões e, por último, (iii) os textos completos. Ao final, restaram 6 estudos que efetivamente versaram sobre o tema. Após análise da produção científica, concluiu-se que, apesar das limitações em decorrência de alguns fatores como os meteorológicos e os relativos à fisiologia e anatomia dos vegetais, os biomonitores apresentam bons resultados quando utilizados para monitoramento da qualidade do ar.
Uma análise sobre o estado nutricional e comportamental de dependentes químicos
Authors: Oliveira Keitte Ribeiro de , Moraes Nathane Sarkis Portes de , Maynard Dayanne da Costa
Published: June 2023

As drogas são um problema na saúde pública que cada vez mais vem crescendo e impactando todo o mundo, sendo o Brasil um dos maiores consumidores. Além disso, é uma doença que impacta o ser humano, em todas as áreas e que precisa de acompanhamento de uma equipe multiprofissional, podendo causar distúrbios alimentares e, posteriormente, acarretar uma obesidade, porém, este tema ainda carece de estudos. Tendo em vista, tratar-se de um tema com grande importância para a saúde pública, o objetivo deste trabalho foi analisar o estado nutricional e comportamental de dependentes químicos. Foi realizado um estudo do tipo transversal, descritivo, exploratório e qualitativo. Os questionários aplicados foram QFA, EAT 26, teste ASSIST e recordatório de 24 horas, além da aferição antropométrica, em uma amostra de indivíduos que estão em tratamento do uso de drogas, no Instituto Crescer, em duas regiões administrativas do DF. Por meio dos resultados obtidos observou-se que 84% da amostra eram usuários de múltiplas drogas e em relação ao comportamento alimentar após o início do tratamento, 63,2% dos participantes relataram aumento da ingestão de alimentos doces. Sobre o estado nutricional, a maioria se enquadra na classificação de baixo peso e 24,3% positivou para risco de desenvolver algum transtorno alimentar. Mediante ao que foi exposto, é fundamental uma terapêutica multiprofissional, destacando o papel exercido pelo nutricionista, visto que o mesmo é necessário para realizar os ajustes na terapia nutricional do indivíduo, visando reduzir possíveis danos gerados no hábito alimentar, promovendo saúde e qualidade de vida.
Áreas de atenção na harmonização orofacial: uma revisão narrativa da literatura
Authors: Rodrigues Sandra Selma de Araújo , Suguihara Roberto Teruo , Muknicka Daniella Pilon
Published: June 2023

A busca por procedimentos faciais para rejuvenescimento tem se popularizado cada vez mais, tanto entre mulheres quanto homens. No entanto, é importante estar ciente dos riscos envolvidos, como intercorrências que podem levar a resultados indesejados. Os procedimentos mais comuns incluem o preenchimento com ácido hialurônico e aplicação de toxina botulínica, que requerem cuidados específicos com a área tratada. Para evitar efeitos indesejados causados por procedimentos invasivos, é essencial que os especialistas em harmonização orofacial (HOF) tenham um conhecimento aprofundado da anatomia da região. É necessário que esses profissionais tenham habilidades manuais precisas e respeitem os limites da anatomia, visando resultados harmoniosos e naturais para os pacientes. A segurança e a preocupação com a anatomia do paciente devem ser prioridades em qualquer procedimento de HOF. A área da HOF está em constante evolução, e é fundamental que os especialistas busquem aprimorar seus conhecimentos por meio de cursos, especializações e estudos científicos. Além disso, é necessário investir em pesquisas científicas para o desenvolvimento de tecnologias que reduzam reações adversas aos procedimentos. Dessa forma, será possível oferecer tratamentos mais seguros e eficazes, proporcionando resultados cada vez mais satisfatórios aos pacientes. Assim, essa revisão narrativa da literatura tem por objetivo analisar os cuidados necessários durante a execução de procedimentos de HOF, visto que são abordados temas como áreas de risco, anatomia dos nervos, veias, vasos sanguíneos, músculos e ossos da face.
Trends of vitamin D in asthma in the pediatric population for two decades: a systematic review
Authors: Sung Myongsoon
Published: June 2023

Vitamin D exhibits anti-inflammatory properties through multiple mechanisms. Vitamin D deficiency is associated with increased inflammation, exacerbations, and overall worse outcomes in pediatric asthma and is observed in asthmatic children with obesity. In addition, given the increase in the prevalence of asthma over the last few decades, there has been enormous interest in vitamin D supplementation as a potential therapeutic option. However, recent studies have suggested no strong association between vitamin D levels or supplementation and childhood asthma. Recent studies have reported that obesity and vitamin D deficiency are associated with increased asthma symptoms. Thus, this review summarizes the findings of clinical trials regarding the role of vitamin D in pediatric asthma and analyzes the study trends of vitamin D over the past 2 decades.
Inferior vena cava to aorta ratio in dehydrated pediatric patients: a systematic review and meta-analysis
Authors: Octavius Gilbert Sterling , Imanuelly Michelle , Wibowo Johan , Heryadi Nadia Khoirunnisa , Widjaja Melanie
Published: June 2023

Background: Dehydration due to acute diarrhea is among the leading causes of mortality. However, advancements in management and technology do not help clinicians differentiate dehydration degrees. Ultrasound using the inferior vena cava to aorta (IVC/ Ao) ratio is a promising noninvasive technique to identify significant pediatric dehydration.Puspose: Therefore, this systematic review and meta-analysis aimed to examine the diagnostic parameters of the IVC/Ao ratio for predicting clinically significant dehydration in pediatric patients.Methods: We searched the MEDLINE, PubMed, Cochrane Library, ScienceDirect, and Google Scholar databases for studies of pediatric patients (≤18 years old) who presented with signs and symptoms of dehydration due to acute diarrhea, gastroenteritis, or vomiting. The inclusion criteria were cross-sectional, case-control, cohort, and randomized controlled trial study design and publication in any language. We then conducted a meta-analysis using the midas and metandi commands from Stata software.Results: Five studies of 461 patients were included. The combined sensitivity was 86% (95% confidence interval [CI], 79%–91%), while the specificity was 73% (95% CI, 59%–84%). The area under the curve was 0.89 (95% CI, 0.86–0.91). The positive likelihood ratio (LR+) was 3.2 (95% CI, 2.1–5.1) with a 76% posttest probability, while the negative likelihood ratio (LR-) was 0.18 (95% CI, 0.12–0.28) with a 16% posttest probability. The combined negative predictive value was 0.83 (95% CI, 0.75–0.91), while the positive predictive value was 0.75 (95% CI, 0.68–0.82).Conclusion: The IVC/Ao ratio was insufficient to exclude or confirm significant dehydration in pediatric patients. More studies are needed, especially multicenter, adequately powered diagnostic research, to will help establish the usefulness of the IVC/Ao ratio
Community-acquired pneumonia in children: updated perspectives on its etiology, diagnosis, and treatment
Authors: Yun Ki Wook
Published: June 2023

Pneumonia is a common pediatric infectious disease that is familiar to pediatricians and a major cause of hospitalization worldwide. Recent well-designed epidemiologic studies in developed countries indicated that respiratory viruses are detected in 30%–70%, atypical bacteria in 7%–17%, and pyogenic bacteria in 2%–8% of children hospitalized with community-acquired pneumonia (CAP). The etiological distribution of CAP varies widely by child age and the epidemiological season of the respiratory pathogen. Moreover, diagnostic tests, particularly for the detection of Streptococcus pneumoniae and Mycoplasma pneumoniae, the 2 major bacterial pathogens involved in pediatric CAP, have several limitations. Therefore, management and empirical antimicrobial therapy for children with CAP should be applied in a stepwise manner based on recent epidemiological, etiological, and microbiological evidence.
Sikap, Aksesibilitas, Peran Kader dan Dukungan Keluarga dengan Keaktifan Mengikuti Posyandu pada Lansia
Authors: Guspianto Guspianto , Sari Endang , Wardiah Rizalia
Published: June 2023

Jumlah posyandu yang ada di Indonesia ada sekitar sebanyak 9 ribu posyandu lansia. Data lansia yang berpartisipasi mengikuti posyandu lansia sekitar sebanyak 45 %. Penelitian ini bertujuan untuk mengetahui hubungan sikap, aksesibilitas, peran kader dan dukungan keluarga dengan keaktifan mengikuti posyandu pada lansia di wilayah kerja Puskesmas Siulak Mukai tahun 2022. Penelitian ini merupakan penelitian kuantitatif dengan menggunakan pendekatan crosssectional. Sampel berjumlah 102 sampel dengan teknik pengambilan sampel menggunakan multistage random sampling. Variabel bebas dalam penelitian ini adalah sikap, aksesibilitas, peran kader dan dukungan keluarga sedangkan variabel terikat adalah keaktifan mengikuti posyandu. Data diperoleh dengan pengisian kuesioner oleh responden. Analisis data dilakukan dengan menggunakan uji univariat dan bivariat (chi-square). Hasil penelitian ini menunjukkan bahwa sebagian besar responden tidak aktif mengikuti posyandu lansia (74,5 %) dan ada hubungan sikap dengan keaktifan mengikuti posyandu pada lansia (0,006), ada hubungan aksesibilitas dengan keaktifan mengikuti posyandu pada lansia (0,000), ada hubungan peran kader dengan keaktifan mengikuti posyandu pada lansia (0,001), ada hubungan dukungan keluarga dengan keaktifan mengikuti posyandu pada lansia (0,000).
Pengaruh Edukasi Terhadap Pengetahuan Siswa Tentang Pencegahan Penyebaran Virus Covid-19
Authors: Ath Thaariq Nurul Aziza , Ningsih Mahdalena Prihatin , Rahmawati Lisa , Sandra Yuanita
Published: June 2023

Coronavirus (CoV) is the cause of respiratory system disease with mild to severe symptoms. The first COVID-19 was reported in Indonesia on March 2, 2020, with as many as two cases. The Indonesian Pediatrician Association West Sumatera recorded that until July 25, 2021, 8,429 children from the age of 0-18 years were attacked by Covid-19. Prevent the transmission by implementing health protocols (wearing masks, washing hands, keeping distance, staying away from crowds, and limiting mobility). Observations show that there are people who do not follow these regulations. The purpose of this study was to determine the effect of education on students' knowledge about preventing the spread of the Covid-19 virus. The type of research used is quantitative research with a quasi-experimental study with a one-group pretest-posttest research design. This study used a group that was given an educational intervention using PowerPoint, video, and demonstrations. Sampling technique with a total population of 36 respondents. Processing data using paired T-test. The average value after being given education (18.17) was higher than before (16.19) with p-value = 0.000. It can be concluded that education affects students' knowledge about preventing the spread of the Covid-19 virus at SDN 17 Gunung Pangilun Padang. The school is advised to implement health protocols in schools to prevent the spread of Covid-19 at SDN 17 Gunung Pangilun Padang.
Pengaruh Variasi Konsentrasi Chitosan Sebagai Bahan Penghancur Terhadap Sifat Fisik Sediaan Orally Disintegrating Tablet (ODT) Paracetamol
Authors: Sulistriyani Kristin , Nawangsari Desy , Kurniasih Khamdiyah Indah
Published: June 2023

An antipyretic analgesic drug called paracetamol is used in children to treat mild to moderate pain and fever. Orally Disintegrating Tablet (ODT), a medicine that dissolves in seconds, was created to help children who have difficulty swallowing tablets. The purpose of this study was to determine the effect of changes in the concentration of chitosan as a disintegrant in the formulation of ODT paracetamol. These ODT tablets are made using a wet granulation process. Paracetamol ODT tablets were produced in three formulations with 3.5% chitosan concentration; 7% and 14%. The findings showed that the optimal concentration of chitosan was 3.5%, which had an impact on the physical characteristics and dissolution of tablets. The results showed that paracetamol F1 ODT preparation with 3.5% chitosan concentration was the best formula. This was caused by chitosan with an average weight uniformity test value of 202.65±2.00 mg; uniformity of diameter and thickness 0.831±0.008 cm and 0.343±0.008 cm, hardness 5.4±0.34 kg; brittleness 0.23±0.02; disintegration time 24 seconds; da dissolution 99.56%. The findings for hardness (p= 0.011), friability (p= 0.046), and disintegration time (p= 0.000) all showed significant variation (p 0.05). It was concluded that the disintegration time of the tablets increased with the increase in the chitosan content. It is recommended that further research be conducted for analgesic and antipyretic tests to determine whether the tablets have an effective analgesic and antipyretic effect.
Analisis Perbedaan antara Bidan Delima dengan Non Delima dalam Pemberian Pelayanan KIA dan KBKR selama Masa Pandemi Covid-19
Authors: Nuraisya Wahyu
Published: June 2023

The Covid-19 pandemic has had an impact on the life sector, one of which is the decline in the quality of midwifery services. The aim of this study was to analyze the differences between midwives in Delima and non-Delima in the delivery of Maternal and Child Health (MCH) and Reproductive Health Family Planning (KBKR) services during the Covid-19 Pandemic. The study was conducted comparatively with a cross-sectional approach. The research population was midwives supervising clinical practice students of the D3 Midwifery Study Program, STIKES Karya Husada Kediri. The sampling technique used simple random sampling, a sample of 92 respondents (delima and non-pomegranate midwives each 46 respondents). Data collection used a questionnaire from March 25 to July 26, 2021. Descriptive and bivariate univariate analysis techniques using the Mann Whitney test with a significance value (α=0.05) obtained all p values for each of the results of the analysis of differences in the status of pomegranate midwives and non-delima by providing pregnancy, delivery, post partum, postpartum, breastfeeding and family planning services > (more) than a significance value of α=0.05, it is stated that there is no difference between these variables. The conclusion is that there is no difference between the services provided by midwives with Delima midwife status and non-Delima midwives. Suggestions for further research other variables are the level of client satisfaction between the services of pomegranate and non pomegranate midwives.
Daya Terima Fortifikasi Tepung Eucheuma Cottonii pada Produk Dimsum sebagai Alternatif Pangan Kaya Serat
Authors: Sihite Nathasa Weisdania , Eliza Eliza , Zebua Elva Amurita
Published: June 2023

Fortification, which is known as food enrichment for processed food products, has recently been frequently studied. The fortification of Eucheuma cottonii seaweed flour was carried out to manufacture dimsum products that aim to produce fiber-rich food. This research aims to analyze the acceptability of Eucheuma cottonii flour fortification on dimsum, and to analyze the proximate content of the product by chemical analysis. The method used in this study is experimental research, with a completely randomized design (CRD) with three formulas, namely F1 (25%), F2 (45%), and F3 (55%). Data had analyzed statistically with the non-parametric Kruskal Wallis-Mann Whitney test. Based on the test results, it was explained that there was a significant effect of color (p=0.047), taste (p=0.004), and texture (p=0.000). The results explained that the fortification of Eucheuma cottonii flour affected the color, taste, and texture and the color of the dimsum became grainy (sticky, grainy, and chewy). The addition of fortified seaweed flour (Eucheuma cottonii) can increase the percentage of fiber in dimsum products, namely dietary fiber (3.24-3.80% body weight) and crude fiber (0.37-0.49% body weight). The research concluded that fortification of Eucheuma cottonii flour was organoleptically acceptable and could use as a menu recommendation for food products that are high in fiber. It is necessary to pay more attention to the determination of the flour concentration level in detail because the main component of seaweed is colloidal.
Effect of oligonucleotide MT01 delivered by N-isopropylacrylamide modified polyethyleneimine for bone regeneration
Authors: Zhang Qian , Qu Xingyuan , Liang Chen , Li Hongyan , Du Siyu , Wang Chang , Xie Yuandong , Zheng Yi , Wang Lei
Published: June 2023

Objective: This study aimed to investigate the regulatory effect of N-isopropylacrylamide-modified polyethyleneimine (PEN)-delivered oligodeoxynucleotide (ODN) MT01 on bone regeneration in vitro and in vivo.

Methods: A polyethylenimine (PEI) derivative, PEN, was constructed through Michael addition and employed as a carrier for ODN MT01 transfection. PEN/MT01 nanocomposites were characterized using agarose gel retardation assay, size distribution, zeta potential and transmission electron microscopy. The Cell Counting Kit-8 (CCK-8) assay was used to detect the effect of PEN on cell viability. Alkaline phosphatase (ALP) staining was used to detect the osteogenic differentiation ability of PEN/MT01 nanocomposite. Real-time quantitative PCR (q RT-PCR) and enzyme-linked immunosorbent assay (ELISA) were used to detect the regulatory effects of PEN/MT01 nanocomposite on osteogenic differentiation gene expression. Rat model was observed using the skull defect method and verified using micro-computed tomography (CT), serum biochemical indices, hematoxylin and eosin (H&E) staining and Immunohistochemistry (IHC).

Results: PEN had good biological properties and could deliver MT01 well to achieve efficient transmission of MT01. PEN/MT01 nanocomposites were effectively transfected into MC3T3-E1 cells at a ratio of 6.0. CCK-8 assay displayed that PEN had no cytotoxicity to MC3T3-E1 cells. Additionally, PEN/MT01 nanocomposites could promote the expression of osteogenic genes. In vivo results revealed that PEN/MT01 nanocomposites could promote bone regeneration more effectively than the other groups.

Conclusion: PEN has good biocompatibility and low toxicity, which is a good carrier for ODN MT01. PEN-delivered MT01 can be potentially employed as a useful approach to achieving bone regeneration.
Communicating complex numeric information in clinical research
Authors: Bierer Barbara E. , Baedorf Kassis Sylvia
Published: June 2023

The ability to understand and use numeric information in healthcare and clinical research is a critical component of informed decision-making for patients and study participants. Health numeracy levels in the general population, however, tend to be quite low and as such, the responsibility falls on communicators to ensure that the information being shared is designed to facilitate recipient comprehension and support their autonomy. Here, we introduce health numeracy considerations within the clinical research context and outline specific areas that can benefit from thoughtful communication strategies, including the presentation of visual information to augment the interpretation of, and learning about, research studies. Specifically, we discuss seven categories of numeric concepts that arise throughout the course of research participation and important considerations when presenting such information. Increasing awareness amongst communicators about health numeracy and the need to include supportive visual representations when developing and sharing clinical research-related information will help support the creation of tailored information that meets the needs of the intended audience.
Identification of potential drug targets for varicose veins: a Mendelian randomization analysis
Authors: Lin Jianfeng , Zhou Jiawei , Liu Zhili , Zeng Rong , Wang Lei , Li Fangda , Cui Liqiang , Zheng Yuehong
Published: June 2023

Introduction

Varicose veins are a common chronic disease that creates a significant economic burden on the healthcare system. Current treatment options, including pharmacological treatments, are not always effective, and there is a need for more targeted therapies. A Mendelian randomization (MR) method uses genetic variants as instrumental variables to estimate the causal effect of an exposure on an outcome, and it has been successful in identifying therapeutic targets in other diseases. However, few studies have used MR to explore potential protein drug targets for varicose veins.

Methods

To identify potential drug targets for varicose veins of lower extremities, we undertook a comprehensive screen of plasma protein with a two-sample MR method. We used recently reported cis-variants as genetic instruments of 2,004 plasma proteins, then applied MR to a recent meta-analysis of genome-wide association study on varicose veins (22,037 cases and 437,665 controls). Furthermore, pleiotropy detection, reverse causality testing, colocalization analysis, and external replication were utilized to strengthen the causal effects of prioritized proteins. Phenome-wide MR (PheW-MR) of the prioritized proteins for the risk of 525 diseases was conducted to screen potential side effects.

Results

We identified eight plasma proteins that are significantly associated with the risk of varicose veins after Bonferroni correction (P < 2.495 × 10−5), with five being protective (LUM, POSTN, RPN1, RSPO3, and VAT1) and three harmful (COLEC11, IRF3, and SARS2). Most identified proteins showed no pleiotropic effects except for COLLEC11. Bidirectional MR and MR Steiger testing excluded reverse causal relationship between varicose veins and prioritized proteins. The colocalization analysis indicated that COLEC11, IRF3, LUM, POSTN, RSPO3, and SARS2 shared the same causal variant with varicose veins. Finally, seven identified proteins replicated with alternative instruments except for VAT1. Furthermore, PheW-MR revealed that only IRF3 had potential harmful adverse side effects.

Conclusions

We identified eight potential causal proteins for varicose veins with MR. A comprehensive analysis indicated that IRF3, LUM, POSTN, RSPO3, and SARS2 might be potential drug targets for varicose veins.
Identify Tcea3 as a novel anti-cardiomyocyte hypertrophy gene involved in fatty acid oxidation and oxidative stress
Authors: Guo Yingying , Cen Xian-feng , Li Dan , Qiu Hong-liang , Chen Ya-jie , Zhang Meng , Huang Si-hui , Xia Hao , Xu Man
Published: June 2023

Background

Chronic pressure overload triggers pathological cardiac hypertrophy that eventually leads to heart failure. Effective biomarkers and therapeutic targets for heart failure remain to be defined. The aim of this study is to identify key genes associated with pathological cardiac hypertrophy by combining bioinformatics analyses with molecular biology experiments.

Methods

Comprehensive bioinformatics tools were used to screen genes related to pressure overload-induced cardiac hypertrophy. We identified differentially expressed genes (DEGs) by overlapping three Gene Expression Omnibus (GEO) datasets (GSE5500, GSE1621, and GSE36074). Correlation analysis and BioGPS online tool were used to detect the genes of interest. A mouse model of cardiac remodeling induced by transverse aortic constriction (TAC) was established to verify the expression of the interest gene during cardiac remodeling by RT-PCR and western blot. By using RNA interference technology, the effect of transcription elongation factor A3 (Tcea3) silencing on PE-induced hypertrophy of neonatal rat ventricular myocytes (NRVMs) was detected. Next, gene set enrichment analysis (GSEA) and the online tool ARCHS4 were used to predict the possible signaling pathways, and the fatty acid oxidation relevant pathways were enriched and then verified in NRVMs. Furthermore, the changes of long-chain fatty acid respiration in NRVMs were detected using the Seahorse XFe24 Analyzer. Finally, MitoSOX staining was used to detect the effect of Tcea3 on mitochondrial oxidative stress, and the contents of NADP(H) and GSH/GSSG were detected by relevant kits.

Results

A total of 95 DEGs were identified and Tcea3 was negatively correlated with Nppa, Nppb and Myh7. The expression level of Tcea3 was downregulated during cardiac remodeling both in vivo and in vitro. Knockdown of Tcea3 aggravated cardiomyocyte hypertrophy induced by PE in NRVMs. GSEA and online tool ARCHS4 predict Tcea3 involved in fatty acid oxidation (FAO). Subsequently, RT-PCR results showed that knockdown of Tcea3 up-regulated Ces1d and Pla2g5 mRNA expression levels. In PE induced cardiomyocyte hypertrophy, Tcea3 silencing results in decreased fatty acid utilization, decreased ATP synthesis and increased mitochondrial oxidative stress.

Conclusion

Our study identifies Tcea3 as a novel anti-cardiac remodeling target by regulating FAO and governing mitochondrial oxidative stress.