bluuebunny/crossref_metadata_2025 huggingface dataset:
Bioelectricity Generation From Single-Chamber Microbial Fuel Cells With Various Local Soil Media and Green Bean Sprouts as Nutrient
Authors: Mulyono Tri , Misto Misto , Busroni Busroni , Siswanto Siswanto
Published: July 2020

In this experiment, seven single-chamber microbial fuel cells (MFCs) were made and filled with various types of local agricultural soil and sediments found in irrigation channels, which were mixed with glucose and green bean sprouts mashed as nutrients for microbial survival. MFC electric power was measured every day for 35 days. Every time low electric power indicated weak microbial activity, green bean sprouts were added. The highest electric power of 118 µW (23.4 mW/m2) was observed in fuel cells filled with agricultural land planted with rice. Power density reached the range of 120–140 mW/m2, whereas the incubation time showed a maximum of 35 days. This study found that adding green bean sprouts can increase the length of the MFC cycle and strengthen the generated power up to 122 mW. ©2020. CBIORE-IJRED. All rights reserved
Variation in contents of active components and antibacterial activity in different parts of Lonicera japonica Thunb
Authors: Yan Luyun , Xie Yulei , Wang Youyou , Zhu Jinhua , Li Mingjing , Liu Xiuhua , Zhao Dongbao
Published: July 2020

Background

Lonicera japonica Thunb has been comprehensively used as a traditional Chinese medicine which contains a variety of medicinally active substances.

Objectives

The active constituents in various parts of L. japonica Thunb (leaves [LE], flowers fl, and green buds [GB]) were studied to rational and efficient use of this medicinal plant.

Methods

UV–vis spectrophotometry was used for the determination of the total flavonoids; gas chromatography–mass spectrometric method was employed for the analysis of volatile components; and high-performance liquid chromatography technology was applied to detect nine bioactive components including chlorogenic acid, neochlorogenic acid, isochlorogenic acid C, caffeic acid, luteolin, galuteolin, hyperoside, rutin, and quercetin in different parts of L. japonica Thunb. The antimicrobial effects of LE, FL, and GB were further measured using agar plate drilling method.

Results

The content of the total flavonoids in different portions of L. japonica Thunb has significant difference, and the content with the decreasing sequence is found in GB, LE, and FL. The contents of main volatile components were highest in FL, followed by GB and LE. Besides, the contents of galuteolin, luteolin, rutin, and isochlorogenic acid C were higher in LE than those in FL and GB, and neochlorogenic acid content was similar in LE and FL. The antimicrobial effects showed that LE had the best inhibitory activity on Staphylococcus aureus (SA) and extended spectrum β-lactamases SA.

Conclusions

The research in this study provided valuable evidences for the reasonable and efficient utilization of L. japonica Thunb.
Detection of brain metastases using alternative magnetic resonance imaging sequences: a comparison between SPACE and VIBE sequences
Authors: Kongpromsuk Sutasinee , Pitakvej Nantaporn , Jittapiromsak Nutchawan , Prakkamakul Supada
Published: July 2020

Background

Accurate identification of brain metastases is crucial for cancer treatment.

Objectives

To compare the ability to detect brain metastases of two alternative types of contrast-enhanced three-dimensional (3D) T1-weighted sequences called SPACE (Sampling Perfection with Application optimized Contrasts using different flip angle Evolutions) and VIBE (Volumetric Interpolated Brain Sequence) on magnetic resonance imaging (MRI) at 3 tesla.

Methods

Between April 2017 and February 2018, 27 consecutive adult Thai patients with a total number of 424 brain metastases were retrospectively included. The patients underwent both contrast-enhanced 3D T1-weighted SPACE and 3D T1-weighted VIBE MRI sequences at 3 tesla. Two neuroradiology experts independently reviewed the images to determine the number of enhancing lesions on each sequence. Wilcoxon signed rank test was used to compare the difference between the numbers of detectable parenchymal enhancing lesions. Interobserver reliability was calculated using intraclass correlation.

Results

3D T1-weighted SPACE detected more parenchymal enhancing lesions than 3D T1-weighted VIBE (424 vs. 378 lesions, median 6 vs. 5, P = 0.008). Fifteen patients (55.6%) had equal number of parenchymal enhancing lesions between two sequences. 3D T1-weighted SPACE detected more parenchymal enhancing lesions (up to 9 more lesions) in 10 patients (37%), while 3D T1-weighted VIBE detected more enhancing lesions (up to 2 more lesions) in 2 patients (7.4%). Interobserver reliability between the readers was excellent.

Conclusion

Contrast-enhanced 3D T1-weighted SPACE sequence demonstrates a higher ability to detect brain metastases than contrast-enhanced 3D T1-weighted VIBE sequence at 3 tesla.
A simple model to detect atrial fibrillation via visual imaging
Authors: Corino Valentina D. A. , Iozzia Luca , Scarpini Giorgio , Mainardi Luca T. , Lombardi Federico
Published: July 2020

Automatic detection of atrial fibrillation (AF) is a challenging issue. In this study we proposed and validated a model to identify AF by using facial video recordings. We analyzed photoplethysmographic imaging (PPGi) signals, extracted from video of a subject’s face. Sixty-eight patients were included: 30 in sinus rhythm (SR), 25 in AF and 13 presenting with atrial flutter or frequent ectopic beats (ARR). Twenty-six indexes were computed. The dataset was divided in three subsets: the training, validation, and test set, containing, respectively, 58, 29, and 13% of the data. Mean of inter-systolic interval series (M), Local Maxima Similarity (LMS), and pulse harmonic strength (PHS) indexes were significantly different among all groups. Variability and irregularity parameters had the lowest values in SR, the highest in AF, with intermediate values in ARR. The PHS was higher in SR than in ARR, and higher in ARR than in AF. The LMS index was the highest in SR, intermediate in ARR and the lowest in AF. Similarity indexes were higher in SR than in AF and ARR. A model with three features, namely M, Similarity1 and LMS was chosen. With this model, the accuracy for the validation set was 0.947±0.007 for SR, 0.954±0.004 for AF and 0.919±0.006 for ARR; for the test set (never-seen data), accuracy was 0.876±0.021 for SR, 0.870±0.030 for AF and 0.863±0.029 for ARR. A contactless video-based monitoring can be used to detect AF, differentiating it from SR and from frequent ectopies.
Analysis of livestock breeders’ perceptions and their adaptation measures to climate change in Morocco‘s arid rangelands
Authors: Snaibi Wadii
Published: July 2020

The high plateaus of eastern Morocco are already suffering from the adverse impacts of climate change (CC), as the local populations’ livelihoods depend mainly on extensive sheep farming and therefore on natural resources. This research identifies breeders’ perceptions about CC, examines whether they correspond to the recorded climate data and analyses endogenous adaptation practices taking into account the agroecological characteristics of the studied sites and the difference between breeders’ categories based on the size of owned sheep herd. Data on perceptions and adaptation were analyzed using the Chi-square independence and Kruskal-Wallis tests. Climate data were investigated through Mann-Kendall, Pettitt and Buishand tests.

Herders’ perceptions are in line with the climate analysis in term of nature and direction of observed climate variations (downward trend in rainfall and upward in temperature). In addition, there is a significant difference in the adoption frequency of adaptive strategies between the studied agroecological sub-zones (χ2 = 14.525, p <.05) due to their contrasting biophysical and socioeconomic conditions, as well as among breeders’ categories (χ2 = 10.568, p < .05) which attributed mainly to the size of sheep flock. Policy options aimed to enhance local-level adaptation should formulate site-specific adaptation programs and prioritise the small-scale herders.
Solving biharmonic problems on irregular domains by stably evaluated Gaussian kernel
Authors: Krowiak Artur
Published: July 2020

The paper extends recently developed idea of stable evaluation of the Gaussian kernel. Owing to this, the Gaussian radial basis function that is sensitive to the shape parameter can be stably evaluated and applied to interpolation problems as well as to solve differential equations, giving highly accurate results. But it can be done only with grids being the Cartesian product of sets of points, what limits the use of this idea to rectangular domains. In the present paper, by the association of an appropriate transformation with the mentioned method, the latter is applied to solve biharmonic problems on quadrilateral irregular domains. As an example, in the present work this approach is applied to solve bending as well as free vibration problem of thin plates. In the paper some strategies for the implementation of the boundary conditions are also presented and examined due to the accuracy. The numerical tests show high accuracy and usefulness of the method.
Estimation of permeability and saturation based on imaginary component of complex resistivity spectra: A laboratory study
Authors: Jia Jiang , Ke Shizhen , Li Junjian , Kang Zhengming , Ma Xuerui , Li Manman , Guo Jieyi
Published: July 2020

Low-frequency resistivity logging plays an important role in the field of petroleum exploration, but the complex resistivity spectrum of rock also contains a large amount of information about reservoir parameters. The complex resistivity spectra of 15 natural sandstone cores from western China, with different water saturations, were measured with an impedance analyzer. The pore space of each core was saturated with NaCl solution, and measurements were collected at a frequency range of 40–15 MHz. The results showed a linear relationship between the real resistivity at 1 kHz and the maximum values of imaginary resistivity for each core with different water saturations. The slopes of the linear best-fit lines had good linear relationships with the porosity and the permeability of cores. Based on this, a permeability estimation model was proposed and tested. In addition, the maxima of imaginary resistivity had power exponential relationships with the porosity and the water saturation of the cores. A saturation evaluation model based on the maxima of imaginary resistivity was established by imitating Archie’s formula. The new models were found to be feasible for determining the permeability and saturation of sandstone based on complex resistivity spectrum measurements. These models advance the application of complex resistivity spectrum in petrophysics.
A progestin isn’t a progestin: dienogest for endometriosis as a blueprint for future research – Review as a contribution for discussion -
Authors: Oettel Michael , Zentel Hans Joachim , Nickisch Klaus
Published: July 2020

The different etiopathogenetic mechanisms and the diversity of clinical features of endometriosis has not yet allowed to identify a causal pharmacological monotherapy satisfying the unresolved medical needs in this important female disease. Therefore, despite the search for new therapeutic principles for the indication, the strategy of gradual optimization of established therapeutic principles should not be disregarded.

In the case of progestins, the fact that each compound has its own, specific profile may allow to study the therapeutic relevance of the various signal cascades influenced by their receptors.

Using the example of the progestin dienogest, the different genomic and non-genomic mechanisms of action are discussed. It is pharmacodynamic profile is unique compared to other progestins.

In light of the emerging multitude of pathomechanisms in endometriosis, a monotherapy may not be possible, and then the search for broad spectrum compounds or combination therapies with dual or multiple mode of action in a clinically relevant dose range might be considered. The progestogenic action may greatly benefit from, by way of example, additional anti-inflammatory and/or anti-fibrotic and/or pro-apoptotic activities. Such a strategy could lead to new drug classes.
The link between dynamic hyperinflation, autonomic dysfunction and exercise testing parameters with masked heart failure in patients with non-severe obstructive pulmonary disease
Authors: Cherneva Radostina Vl. , Denchev Stefan Veselinov , Cherneva Zheina Vl.
Published: July 2020

Objectives

Autonomic dysfunction (AD) and dynamic hyperinflation (DH) have been implicated as pathophysiological mechanisms of heart failure with preserved ejection fraction (HFpEF) in chronic obstructive pulmonary disease (COPD) patients. Their association, however, remains elusive: The aims of the study were: (1) to determine the prevalence of AD and DH in non-severe COPD patients, with exertional dyspnea, without clinically overt cardio-vascular (CV) comorbidities; (2) to analyze the correlation and clinical significance between DH, AD, and maksed HFpEF.

Methods

We applied CPET in 68 subjects. Echocardiography was performed before CPET and 1–2 min after peak exercise. IC manoeuvres were applied. Patients were divided into two groups: patients with and without masked HFpEF. Wilkoff method calculated the meatabolic – chronotropic relationship (MCR). Chronotropic incompetence (CI) and abnormal HR recovery (HRR) were determined.

Results

The prevalence of CI was 77 vs. 52% in patients with/without masked HFpEF; of abnormal HRR – 98 vs. 62% respectively; of DH – 53 vs. 29%. ICdyn was associated with AD. Univariate regression showed association between masked HFpEF, ICdyn, HRR, oxygenuptake (’VO2), ’VO2 at anaerobic threshold, oxygen (O2) pulse and ’VE/’VCO2 slope. None of these parameters is an independent predictor for masked HFpEF.

Conclusions

DH, AD, and masked HFpEF are prevalent in non-severe COPD patients, who complain of exertional dyspnea and are free of clinically overt CV comorbidities. DH is independently associated with AD. Neither AD, nor DH and CPET are independent predictors for masked HFpEF.
Autoimmune hyperthyroidism in children & adolescents in Sudan: a 13 years’ experience of a Paediatric Endocrinology Clinic
Authors: Fadlalbari Ghassan Faisal , Mukhwana Renson O. , Abdullah Mohamed Ahmed
Published: July 2020

Background

Little has been published about hyperthyroidism in children from Sudan or Africa. In limited resource countries, lack of facilities and sociocultural factors might make international diagnosis and management guidelines difficult to follow. We aimed to determine the magnitude of autoimmune hyperthyroidism, clinical presentation, diagnosis, management and its outcome in Sudan.

Method

Records of all patients diagnosed as Graves’ disease (GD) or Hashitoxicosis (HTx) were reviewed and missing data filled by interviewing patients and/or their families. Data including age, sex, clinical presentation, investigations, management and outcome were obtained.

Results

Eighty-eight patients, 80 with GD (F:M = 4.7:1) and 8 with HTx (F:M = 7:1), were diagnosed at 11.8 ± 3.05 and 11.23 ± 2.78 years, respectively (p = 0.52). GD patients were diagnosed based on presence of exophthalmos (66.25%), positive thyroid receptor autoantibodies (12.5%), prolonged illness duration (8.75%) or remission failure to only B blocker (16.25%). All GD patients were started on carbimazole and cumulative remission rate was 11.8%, 32.4% and 41.2% by end of the second, third and fourth year respectively, however it plateaus after that. While 12 GD patients underwent surgery, only three opted for radioiodine ablation.

Conclusion

Hyperthyroidism is not an uncommon problem. In absence of laboratory facilities, differentiation between GD and HTx can be made based on clinical grounds. Continuation of medical treatment for 4 years can increase the remission rate to 41.2%. In Sudan, surgery is the preferred method of definitive therapy.
GCK-MODY in a child with cystic fibrosis: the doubt of the treatment plan
Authors: Salzano Giuseppina , Passanisi Stefano , Lucanto Maria Cristina , Costa Stefano , Pajno Giovanni Battista , Lombardo Fortunato
Published: July 2020

Objectives

The diagnosis of cystic fibrosis related diabetes (CFRD) is not often easy as glucose homeostasis may be influenced by various disease-related conditions such as enteral continuous drip feeding, frequent acute illness, use of systemic corticosteroids and other concomitant medications. Other forms of diabetes should be considered in the diagnostic work-up, particularly in the first decade of life.

Case presentation

We hereby present the case of a cystic fibrosis 6-year-old female child diagnosed with glucokinase-maturity onset of diabetes of the young (GCK-MODY). The choice of treatment plan was doubtful since GCK-MODY does not usually require insulin treatment, but hyperglycemia could pose a threat to the respiratory tract. After intensive glucose monitoring, we decided to defer pharmacological treatment based on acceptable daily glycemic control. To date, no worsening in her respiratory function has been revealed.

Conclusions

Recognition of non-CFRD forms of diabetes is fundamental to plan the most suitable treatment and follow-up.
Transition metal catalyzed site-selective cysteine diversification of proteins
Authors: Jbara Muhammad
Published: July 2020

Site-specific protein conjugation is a critical step in the generation of unique protein analogs for a range of basic research and therapeutic developments. Protein transformations must target a precise residue in the presence of a plethora of functional groups to obtain a well-characterized homogeneous product. Competing reactive residues on natural proteins render rapid and selective conjugation a challenging task. Organometallic reagents have recently emerged as a powerful strategy to achieve site-specific labeling of a diverse set of biopolymers, due to advances in water-soluble ligand design, high reaction rate, and selectivity. The thiophilic nature of various transition metals, especially soft metals, makes cysteine an ideal target for these reagents. The distinctive reactivity and selectivity of organometallic-based reactions, along with the unique reactivity and abundancy of cysteine within the human proteome, provide a powerful platform to modify native proteins in aqueous media. These reactions often provide the modified proteins with a stable linkage made from irreversible cross-coupling steps. Additionally, transition metal reagents have recently been applied for the decaging of cysteine residues in the context of chemical protein synthesis. Orthogonal cysteine protecting groups and functional tags are often necessary for the synthesis of challenging proteins, and organometallic reagents are powerful tools for selective, rapid, and water-compatible removal of those moieties. This review examines transition metal-based reactions of cysteine residues for the synthesis and modification of natural peptides and proteins.
Removal of bacterial growth inhibition of anticancer drugs by using complexation materials
Authors: Sangnier Maïté , Bouguéon Guillaume , Berroneau Aude , Dubois Véronique , Crauste-Manciet Sylvie
Published: July 2020

In the context of batch production of cytotoxic drugs in hospital pharmacies with the need of sterility testing, the objective was to validate the use of Rapid Microbiological Method (RMM), and to develop adequate neutralization method in case of inhibition of bacterial growth. The potential microbiological growth inhibitory effect of three anticancer drugs (5 fluorouracil, irinotecan and oxaliplatin) selected for batch production was assessed on BacT/ALERT® system. Among cytotoxic drugs, only 5FU exhibited inhibitory effect on microbiological growth using rapid microbiological method. To counteract this effect our purpose was to use neutralizing agents complexing the drug i. e. activated carbon or ion exchange resins. The microbiological bactericidal concentration of 5FU was very low (1.10–4 mg/mL) indicating the absolute need to neutralize the whole drug before sterility test. The complexation was validated by High Performance Liquid Chromatography control of the residual 5FU concentration in solution after the use of neutralizing agents. Only activated carbon was able to fully capture 5FU when previously diluted at 5 mg/mL. Conversely, the resins, in the condition of the study, were not able to fully capture 5FU whatever the dilution. The microbiological growth on BacT/ALERT® system after active carbon treatment was successfully confirmed with Staphylococcus aureus. Based on this validation results a method was then developed to routinely be able to perform sterility test of the batches produced and was confirmed on five microbiological species (i. e. S. aureus, Pseudomonas aeruginosa, Bacillus subtilis, Candida albicans, Aspergillus brasiliensis). Our work gives a new insight for considering sterility testing by rapid microbiological method even for drugs exhibiting inhibitory effect on microbiological growth.
Bisphenol-A and polycystic ovary syndrome: a review of the literature
Authors: Kechagias Konstantinos S. , Semertzidou Anita , Athanasiou Antonios , Paraskevaidi Maria , Kyrgiou Maria
Published: July 2020

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age with reproductive, metabolic and endocrine implications. While the exact pathophysiological mechanisms of the syndrome are unknown, its heterogeneity suggests a multifactorial causal background. In the last two decades, numerous environmental chemicals, including Bisphenol-A (BPA) that is used in the synthesis of polycarbonate plastics, have been proposed as potential contributors to the aetiology of PCOS. This review provides a holistic overview of the available data regarding the possible relation of PCOS with BPA exposure. We have included a total number of 24 studies. Eleven human case-control and 13 animal studies provided data regarding this potential relation. Accumulating evidence suggests that a correlation between high levels of BPA and the presence of PCOS may exist. Contradicting results from human and animal studies, however, render it difficult to conclude on the exact role of BPA in the pathogenesis of PCOS. BPA may constitute a consequence of the syndrome rather than a cause, but further research is still needed to clarify this. Continued efforts to study the early origins of PCOS, using prospective-designed studies, are required to identify the exact effect of BPA on women with PCOS.
Le plan de l’expression des images: Quelques réflexions sur support et apport
Authors: Dondero Maria Giulia
Published: July 2020

In this article we plan to revisit the notion of substance of the plane of expression, as found in semiotic studies of the image, and how this notion relates to the concepts of purport and form. The article is divided into three parts: The first section gives a brief history of the various ways substance has been addressed in (or excluded from) image analyses based on Greimassian semiotics and Groupe μ rhetoric. Drawing upon Jacques Fontanille’s semiotics of practices and Jean-François Bordron’s theory of iconicity, the second section concerns proposals that attempt to address the “moment” of giving substance in autographic works of art – and also in writing –, through notions of support, application, and the gestural act of inscription. The third section tests these methodological tools on chemical photography and on digital image-making in order to propose a new, specifically semiotic approach to studying the media characteristics of images.
„Das war mir dann zu weit weg von der Quelle“
Authors: Küper Judith , Thiel Corrie
Published: July 2020

Reflexion gilt im Lehrer*innenbildungsdiskurs als Qualitätsgarant. Mit ihr soll das Problem routinisierten Denkens und Handelns bearbeitet werden, indem gewohnte Denk- und Handlungsmuster unter Bezug auf wissenschaftliches Wissen hinterfragt werden. Empirische Untersuchungen zeigen aber, dass Reflexion dieser Art in schulpraktischen Reflexionsformaten kaum stattfindet. Diese Beobachtung wird in dem Beitrag zum Anlass genommen, um ausgehend von einem weiten Verständnis von Reflexion als Rückbeuge auf die eigene Praxis zu untersuchen, wie sich Reflexion in der praktischen Lehrer*innenbildung vollzieht, um von hier aus den Reflexionsbegriff des Lehrer*innenbildungsdiskurses weiterzuentwickeln. Hierfür wird eine Szene aus einem Unterrichtsnachgespräch, das im Rahmen eines Unterrichtsbesuches im Kontext des Referendariats stattfand, gesprächsanalytisch ausgewertet. Anschließend wird vorgeschlagen, mittranszendierenderundsituierenderReflexion zwischen zwei Reflexionsformen zu unterscheiden, die jeweils eigene Leistungen in der Ausbildung von Lehrkräften erbringen. Der Beitrag schließt mit der Darstellung von Implikationen der vorgestellten Befunde für die weitere Diskussion von Reflexion in der Lehrer*innenbildung.
Doubly constrained totally positive line insertion
Authors: Johnson Charles R. , Allen David W.
Published: July 2020

It is shown that in any TP matrix, a line (row or column) with two speci˝ed entries in any positions (and the others appropriately chosen) may be inserted in any position, as long as the two entries are consistent with total positivity. This generalizes an unconstrained result previously proven, and the two may not generally be increased to three or more. Applications are given, and this fact should be useful in other completion problems, as the unconstrained result has been.
Soziale Innovation aus der Perspektive einer poststrukturalistischen Praxistheorie Kritik der parallelen Anwendung von akteur- bzw. praxistheoretischem Paradigma
Authors: Brandauer Roland
Published: July 2020

Die Dortmunder Forschungsgruppe, vertreten durch namhafte Soziolog*innen wie Howaldt, Jacobsen, Kopp und Schwarz, verfolgt das vielversprechende Projekt, Soziale Innovation durch eine (poststrukturalistische) Praxistheorie zu fundieren, um damit nicht zuletzt auch den Stellenwert der Sozialen Innovation gegenüber ökonomischer und technischer Innovation zu erhöhen. Parallel zum Paradigma einer poststrukturalistischen Praxistheorie wird dabei allerdings zugleich ein akteurtheoretisches Paradigma zum Einsatz gebracht. Diese beiden Ansätze erweisen sich jedoch in einem analytischen Theorienvergleich in Bezug auf die für eine Definition von Sozialer Innovation zentralen Begriffe von Subjekt und Intention als widersprüchlich und stark divergierend. In dieser Arbeit wird die These vertreten, dass zwar in einer multiparadigmatischen Auffassung von Wissenschaft einander widersprechende Paradigmen für eine bestimmte Zeit parallel existieren können, dass die Anwendung von sich widersprechenden Paradigmen innerhalb eines Forschungsprogramms jedoch auf logischer, inhaltlicher und wissenschaftstheoretischer Ebene unhaltbar ist.
Basal contralateral aldosterone suppression is rare in lateralized primary aldosteronism
Authors: Desrochers Marie-Josée , St-Jean Matthieu , El Ghorayeb Nada , Bourdeau Isabelle , So Benny , Therasse Éric , Kline Gregory , Lacroix André
Published: July 2020

Context:

Unilateral aldosteronomas should suppress renin and contralateral aldosterone secretion. Complete aldosterone suppression in contralateral adrenal vein sample (AVS) could predict surgical outcomes.

Objectives:

To retrospectively evaluate the prevalence of basal contralateral suppression using Aldosterone (A)contralateral(CL)/Aperipheral(P) as compared to (A/Cortisol(C)CL)/(A/C)P ratio in primary aldosteronism (PA) patients studied in two Canadian centers. To determine the best cut-off to predict clinical and biochemical surgical cure. To compare the accuracy of ACL/AP to the basal and post-ACTH lateralization index (LI) in predicting surgical cure.

Methods:

In total, 330 patients with PA and successful AVS were included; 124 lateralizing patients underwent surgery. Clinical and biochemical cure at 3 and 12 months were evaluated using the PASO criteria.

Results:

Using ACL/AP and (A/C)CL/(A/C)P at the cut-off of 1, the prevalence of contralateral suppression was 6 and 45%, respectively. Using ROC curves, the ACL/AP ratio is associated with clinical cure at 3 and 12 months and biochemical cure at 12 months. (A/C)CL/(A/C)P is associated with biochemical cure only. The cut-offs for ACL/AP offering the best sensitivity (Se) and specificity (Sp) for clinical and biochemical cures at 12 months are 2.15 (Se: 63% and Sp: 71%) and 6.15 (Se: 84% and Sp: 77%), respectively. Basal LI and post-ACTH LI are associated with clinical cure but only the post-ACTH LI is associated with biochemical cure.

Conclusions:

In lateralized PA, basal contralateral suppression defined by ACL/AP is rare and incomplete compared to the (A/C)CL/(A/C)P ratio and is associated with clinical and biochemical postoperative outcome, but with modest accuracy.
Teriparatidin ilaçlarla ilişkili çene osteonekrozu tedavisindeki etkinliği: hayvan çalışması
Authors: TOPAN Cihan , KILIÇ Erdem , KILIÇ Eser , ÖZDAMAR Saim , KAYMAK Emin
Published: July 2020

Amaç: Bu çalışmanın amacı, bifosfanat uygulamasını takiben
diş çekimi sonrasında çene kemiklerinde oluşan osteonekrozun tedavisinde
teriparatidin etkinliğinin deneysel olarak araştırılmasıdır. Gereç ve Yöntemler: Wistar Albino ırkı 48 adet dişi rat rastgele
4 gruba ayrıldı: I-Kontrol grubu; II-Zoledronik asit (ZA); III-ZA ve
teriparatid; IV-ZA ve antibiyotik. Osteonekroz oluşturmak için kontrol grubu
dışındaki tüm gruplara 8 hafta boyunca zoledronik asit enjekte edildi. ZA
enjeksiyonlarından bir hafta sonra tüm hayvanların alt çene sol azı dişleri
çekildi ve çekim soketlerinde kemik defekti oluşturuldu. Bu işlemden sonra üçüncü
gruptaki ratlara 2 ay boyunca subkutan olarak teriparatid, dördüncü gruptaki
ratlara 2 hafta boyunca intraperitoneal antibiyotik enjekte edildi. Hayvanlar radyolojik,
histolojik, biyokimyasal ve klinik değerlendirmeler için sakrifiye edildi.Bulgular: Teriparatid uygulamasının biyokimyasal ve radyolojik
açıdan kemik iyileşmesine istatistiksel olarak anlamlı bir etkisinin olmadığı
tespit edilmiştir (p>0,05). Teriparatidin, osteonekroz geliştikten sonra
klinik olarak iyileşmeye tam anlamıyla olumlu etkisinin olmadığı ama oluşan osteonekroz
tablosunun daha da ilerlemesini engellediği gözlenmiştir. Ayrıca, ilacın
histolojik olarak yumuşak doku ve kemik dokusu iyileşmesinde olumlu etkilerinin
olduğu tespit edilmiştir. Sonuç: Bifosfanat
uygulamasını takiben diş çekimi işleminin osteonekroz gelişimine sebep olduğu
gözlenmiştir. Ayrca, teriparatid uygulamasının bu lezyonların tedavisinde
kısmen olumlu etkileri olduğu tespit edilmiştir. Bu tedavinin optimum doz ve
süresinin belirlenmesi için geniş grupları içeren ileri deneysel ve klinik
çalışmalara ihtiyaç vardır.

Anahtar Kelimeler: Bifosfonat, osteonekroz, teriparatid
ÇOCUKLARIN BOYU VE SÜT DİŞLERİNİN KURON BOYUTLARI ARASINDAKİ İLİŞKİ
Authors: ÖZCAN Hazal , YILMAZ Buse , UZ Sinem , İLİSULU Sabiha Ceren , AYDIN Ceren , KORUYUCU Mine , SEYMEN Figen
Published: July 2020

Amaç:Diş gelişimi, çocuklarda
büyüme ve gelişmenin önemli bir göstergesidir. Büyüme sürecinde boy ve kilo
artışı ile diş boyutlarının artışı birbirlerine paralel seyreden
parametrelerdir. Bu çalışmanın amacı; süt dişlerinin kuron boyu ve meziodistal
(MD) genişlikleri ile çocuğun boyu, kilosu ve vücut kitle indeksi (VKİ)
arasındaki ilişkinin belirlenmesidir. Gereç ve Yöntemler:Çalışmaya;
İstanbul Üniversitesi Diş Hekimliği Fakültesi Pedodonti Anabilim Dalı kliniğine
başvurmuş olan 3-6 yaş grubu 68 çocuk (34 kız, 34 erkek) dahil edilmiştir.
Çocukların alt-üst çenesinden ölçü alınarak elde edilen alçı model üzerinden
dijital bir kumpas yardımıyla dişlerin klinik kuron boyu ve meziodistal
genişlik uzunlukları ile çocukların kilo, boy ve yaş değerleri kaydedilmiştir.
Kaydedilen bu değerler arasındaki ilişki istatiksel olarak değerlendirilmiştir.Bulgular:Çalışmaya katılan 68 çocuğun
25’i (%36,8) 3-4 yaş grubunda iken 22’si (%32,4) 5 yaş grubuna, 21’i ise
(%30,9) 6 yaş grubuna dahildir. Tüm yaş gruplarında 5. ve 7. bölgedeki dişlerin
kuron boyu ortalamaları arasında ve meziodistal genişliği arasında anlamlı bir
fark bulunmuştur (p=0,001). Gruplar arası karşılaştırmada erkeklerde #53
numaralı dişin kuron boyu için istatistiksel olarak anlamlılık saptanmıştır
(p=0,019). Değerlendirmeye alınan tüm dişlerin kuron boyu ve MD genişliği ile
VKİ değişkeni ile karşılaştırılmasında anlamlı bir ilişki bulunamamıştır
(p>0,05).Sonuçlar:Bu çalışmada bireyin boyu
ile dişin meziodistal genişliğine göre bireyin boyu ile kuron boyu arasında daha
kuvvetli korelasyon olduğu belirlenmiştir. Bunun sonucunda süt dişlerinin kuron
boyu ve meziodistal genişliğinin, çocukların muhtemel boylarını tahmin etmede
kullanılması ve vücut ölçüleri arasında ilişki kurulmasının değerlendirilebileceği
düşünülmektedir.Anahtar Kelimeler:kuron boyu, meziodistal
genişlik, vücut kitle indeksi
Farklı asitleme işlemlerinin lityum disilikat seramik sistemlerin yüzey pürüzlülüğü ve bağlanma dayanımı üzerine etkileri
Authors: SAYIN ÖZEL Gülsüm , KARA Özlem
Published: July 2020

Amaç: Bu
çalışmanın amacı hidroflorik (Hf) asit ve ısıyla uygulanan deneysel asit ile
pürüzlendirilmiş lityum disilikat seramiklerin rezin siman ile mikro gerilim bağlanma
dayanımlarını değerlendirmektir.Gereç ve Yöntemler:Bu
çalışmada 24 adet çürüksüz insan üçüncü molar diş kullanıldı. Dişler akrilik
rezin bloklara mine-sement sınırının 2 mm aşağısında olacak şekilde gömüldü.
Dişler üzerinde paraskop yardımıyla sınıf I inley kaviteler açıldı. Lityum
disilikat seramik restorasyonlar üretici firma talimatına göre üretildi.
Örnekler 2 gruba ayrıldı. 1) % 9’ luk Hf asit 20 sn), 2) ısıyla uygulanan
deneysel asit 30 dk. Simantasyon işlemlerinden sonra örnekler termal siklusa
(5000 siklus) tabi tutuldu. Sonrasında örneklere 1 mm/dk hızla mikro gerilim bağlanma
testi uygulandı. Elde edilen değerlere bağımsız Örneklem T testi yapıldı (p=0.05).
Yüzey pürüzlülüğü ve mikro gerilim bağlanma değerleri arasındaki ilişkiyi
analiz etmek amacıyla pearson korelasyon katsayısıyla korelasyon testi yapıldı (p=0.01).Bulgular:Hf asit lityum disilikat seramik yüzeylerinde deneysel asit ve ısıyla
karşılaştırıldığında daha fazla pürüzlülüğe ve mikro gerilim bağlanma
değerlerine neden olmuştur. Pearson korrelasyon sayısı, pürüzlülük ile mikro
gerilim bağlanma değerleri arasında yüksek bir değerle pozitif yönde bir
korelasyon olduğunu göstermektedir. Sonuçlar:Hf
asitin toksik etkileri nedeniyle lityum disilikat içerikli cam seramikleri pürüzlendirmede
Hf asitten daha iyi alternatif metodların arayışı devam etmektedir. Anahtar Kelimeler:Deneysel
sıcak asit, Hf asit, Mikro gerilim
bağlanma dayanımı
Educação Integral, Híbrida e Inclusiva na perspectiva Construcionista, Contextualizada e Significativa (CCS)
Authors: Schlünzen Junior Klaus , Moriya Schlünzen Elisa Tomoe , Zaduski Jeong Cir Deborah , Ponzio Sandra Giovina , Lopes da Silva Maria Claudia Leme
Published: July 2020

Nas demandas do século 21, a escola ultrapassa a dimensão do desempenho acadêmico proveniente da acumulação de conteúdos, na direção de um conhecimento mobilizador que exige uma posição protagonista do estudante, isto é, uma possibilidade de saber e fazer. Essa configuração requer um currículo referenciado em competências e, todavia, as competências cognitivas, por si só, não são suficientes para formar esse estudante capaz de enfrentar os desafios do século 21, daí a emergência de uma Educação Integral que vise o desenvolvimento pleno, por meio de competências cognitivas e socioemocionais. O reconhecimento dos prejuízos da fragmentação do conhecimento e da supervalorização da dimensão racional revelou, no campo educacional, a necessidade de ações de integração curricular e de abordagens que promovam o desenvolvimento pleno - cognitivo e socioemocional, mediado pelo uso das tecnologias digitais. A formação de professores com estas competências na perspectiva Construcionista, Contextualizada e Significativa (CCS) é o foco deste artigo, que une a expertise do Instituto Ayrton Senna (IAS) na formação integral com a da equipe da Universidade Estadual Paulista (Unesp), que desenvolve pesquisa relacionadas a formação segundo esta abordagem.
Next Year, Together
Authors: Reisman Emily
Published: July 2020

This commentary describes a virtual seder (the ceremonial Passover meal) as it is reformatted by Covid-19. Dwelling on a shift in the closing lines of the socially-distanced digital dinner from “next year in Jerusalem” to “next year, together,” the essay explores the politics of place in articulations of hope and the role of ritual in potentially rewriting them.
LA CULTURA, LA EDAD Y EL SEXO COMO MEDIADORES DEL AUTOCONCEPTO FÍSICO
Authors: Alemany-Arrebola I. , Cortijo-Cantos A. , Granda-Vera J.
Published: July 2020

La edad y el sexo son variables clave en la construcción del autoconcepto físico, pero en las sociedades actuales, donde conviven diferentes grupos étnicos, el estudio de la influencia de la cultura autóctona es una variable que merece especial atención. La muestra estuvo compuesta por 1911 estudiantes de entre 10 y 17 años (971 mujeres y 940 hombres), utilizando el cuestionario AFAPS como instrumento de medida. Los resultados confirmaron la existencia de mediadores influyentes en el nivel de autoconcepto físico: 1) sexo (p <0,001), siendo los chicos los que obtienen mejores resultados; 2) edad (p <0,05,) ya que el autoconcepto físico mejora con la edad, y 3) cultura (p <0,001), siendo los sujetos pertenecientes a la etnia tamazight que obtienen los valores más altos. Los factores que parecen ser los más influyentes cuando se construye un autoconcepto físico positivo son "Condición física" y "Habilidades motrices".
PERAN PEKERJA SOSIAL DALAM PENDAMPINGAN PSIKOSOSIAL ANAK KORBAN KEKERASAN SEKSUAL DI LEMBAGA KONSULTASI KESEJAHTERAAN KELUARGA (LK3) “MELATI” KABUPATEN KARAWANG
Authors: Kartika Al Ashzim Kartika Al Ashzim
Published: July 2020

Abstract Children are the forerunner of the birth of the next generation that will determine the fate of the nation. Today many children do not get what they are entitled to. That way, the frequent occurrence of violence against children that occurs both in schools, homes, and in public places is more attention to protect children from acts of violence, both physical, psychological and sexual violence. This is the background to understanding the role of social workers in mentoring children victims of sexual violence in LK3 "Melati". This study uses qualitative methods that are descriptive. The results of this study prove that LK3 social workers "Melati" provide assistance by consulting client cases and then referring to relevant institutions. So that the stages of mentoring are carried out using case management stages. The method applied by LK3 social worker "Melati" is casework and case management methods. Of the seven roles of social workers according to Zastrow, social workers at LK3 "Melati" use the role of a case manager in psychosocial assistance to children victims of sexual violence. AbstrakAnak merupakan cikal bakal lahirnya generasi penerus yang akan menentukan nasib bangsa. Saat ini banyak anak yang tidak mendapatkan apa yang menjadi haknya. Dengan begitu, sering terjadinya kekerasan terhadap anak yang terjadi baik di lingkungan  sekolah,  rumah, maupun di tempat umum menjadi perhatian lebih untuk dapat melindungi anak dari tindak kekerasan, baik kekerasan fisik, psikis maupun seksual. Hal tersebut menjadi latar belakang untuk memahami bagaimana peran pekerja sosial dalam pendampingan anak korban kekerasan seksual di LK3 “melati”. Penelitian ini menggunakan metode kualitatif yang bersifat deskriptif. Hasil penelitian ini membuktikan bahwa pekerja sosial LK3 “melati” melakukan pendampingan dengan cara konsultasi kasus klien dan kemudian merujuk ke lembaga-lembaga yang terkait. Sehingga tahapan pendampingan yang dilakukan yaitu memakai tahapan manajemen kasus. Adapun metode yang diterapkan oleh pekerja sosial LK3 “Melati” adalah metode casework dan manajemen kasus. Dari ketujuh peran pekerja sosial menurut Zastrow, pekerja sosial di LK3 “Melati” lebih menggunakan peran sebagai case manager dalam melakukan pendampingan psikososial terhadap anak korban kekerasan seksual.
DAMPAK PROGRAM ELDERLY DAY CARE SERVICE TERHADAP KESEJAHTERAAN LANSIA DI PANTI SOSIAL TRESNA WERDHA BUDI DHARMA BEKASI
Authors: Yulianti Yulianti
Published: July 2020

Abstract. Old age is a phase of a human being in the final life stage before the stage of death. At this stage the elderly require various needs and difficulties they experience, such as physical, psychological, social and spiritual challenges. Therefore, the Bekasi Tresna Budi Dharma Social Home has a program to improve the welfare of the elderly. The institution develops a program for the visiting elderly but receiving the same social services. The program is called Elderly Day Care Service. This research aims at the exploration of the program implementation process and the impact of the Elderly Day Care Service program affecting the welfare of the elderly. This research uses a descriptive qualitative approach. The research data collection technique is by means of interviews, observations, and documentation studies. The results show that the Elderly Day Care Service program at Bekasi Tresna Werdha Budi Dharma Social Home reseults a very positive effect on the elderly participating in the program. In addition, physical, psychological, social and spiritual problems are gradually resolved and make a prosperous elder; active, independent and productive. Abstrak. Lanjut usia merupakan fase seorang manusia berada pada tahap kehidupan akhir sebelum tahap kematian. Pada tahap ini lansia memiliki banyak kebutuhan dan permasalahan yang dialaminya, seperti kendala fisik, psikologis, sosial dan spiritual. Maka dari itu Panti Sosial Tresna Budi Dharma Bekasi memiliki program untuk meningkatkan kesejahteraan lansia. Dan Panti Sosial Tresna Werdha Budi Dharma Bekasi mengembangkan sebuah program bagi lansia yang tidak tinggal di panti namun mendapatkan pelayanan sosial yang sama. Program tersebut bernama Pelayanan Harian Lanjut Usia atau Elderly Day Care Service. Penilitian ini bertujuan untuk mengetahui proses pelaksanaan program dan dampak program Elderly Day Care Service yang dilakukan oleh Panti Sosial Tresna Werdha Budi Dharma Bekasi berpengaruh pada kesejahteraan lansia. Pendekatan dalam penelitian ini menggunakan kualitatif jenis deskriptif. Teknik pengumpulan data penelitian merupakan kumpulan data dari wawancara, observasi, dan studi dokumentasi. Hasil penelitian menunjukan bahwa program Elderly Day Care Service di Panti Sosial Tresna Werdha Budi Dharma Bekasi memiliki pengaruh yang sangat positif bagi para lansia yang mengikuti program tersebut. Selain itu, permasalahan baik fisik, psikis, sosial dan spiritual sedikit demi sedikit teratasi dan menjadikan lansia yang sejahtera yaitu aktif, mandiri dan produktif.
KUALITAS KELEKATAN ANAK DENGAN PENGASUH DI LEMBAGA KESEJAHTERAAN SOSIAL ANAK (LKSA) AL-KAUTSAR LEMBANG KABUPATEN BANDUNG BARAT
Authors: Sholihah Mu'alimatus , Kardeti Denti , Subardhini Meiti
Published: July 2020

Abstract. Attachment refers to a relationship or emotional bonding that last for a long time, intertwined between individuals and attachment figures that are characterized by a desire to seek and maintain closeness to the attachment figures, especially in pressure time. This research aims to gain the empirical description about warmth of children to caregivers. The method in this research uses descriptive method with a quantitative approach.  Sampling in this research is census, and data collection technique uses: 1) questionnaire, 2) interview, 3) observation, and 4) documentation study. As for the measuring instrument validity test uses face validity. Furthermore, the result analysed through quantitative and qualitative analysis. The result shows that the attachment quality of children to caregivers in Al-Kautsar’s Children Welfare Institution Lembang, West Bandung Regency is in moderate category. Therefore, it is necessary to make an improvement throught the proposed program which is EDUFAS (Education and Fun Sharing) “Improvement of The Attachment Quality of Children to Caregivers in Al-Kautsar’s Children Welfare Institution Lembang, West Bandung Regency”. Abstrak. Kualitas kelekatan (attachment) merujuk pada ikatan emosional yang bertahan dalam waktu yang lama, terjalin antara individu dengan figur lekatnya yang ditandai adanya keinginan untuk mencari dan memelihara kedekatan dengan figur lekat tersebut terutama pada saat-saat yang menekan. Penelitian ini bertujuan untuk mendapatkan gambaran empiris tentang kehangatan (warmth) anak dengan pengasuh. Metode penelitian yang digunakan dalam penelitian adalah metode kuantitatif dengan pendekatan deskriptif. Teknik penarikan sampel dalam penelitian ini adalah sensus, yaitu dengan jumlah responden sebanyak 38 anak. Teknik pengumpulan data yang digunakan adalah: 1) kuesioner, 2) wawancara tidak terstruktur, 3) observasi, dan 4) studi dokumentasi. Adapun uji validitas alat ukur menggunakan validitas muka (face validity). Selanjutnya hasil penelitian dianalisis menggunakan analisis kuantitatif dan kualitatif. Hasil penelitian menunjukkan bahwa kualitas kelekatan anak dengan pengasuh di Lembaga Kesejahteraan Sosial Anak Al-Kautsar Lembang Kabupaten Bandung Barat termasuk dalam kategori sedang. Begitu pula pada semua aspek dalam kualitas kelekatan termasuk dalam kategori sedang. Maka dari itu diperlukan upaya peningkatan melalui program yang diusulkan yaitu EDUFAS (Educating and Fun Sharing) “Peningkatan Kualitas Kelekatan Anak dengan Pengasuh di Lembaga Kesejahteraan Sosial Anak (LKSA) Al-Kautsar Lembang Kabupaten Bandung Barat”.
COVID-19 Disease Severity Risk Factors for Pediatric Patients in Italy
Authors: Bellino Stefania , Punzo Ornella , Rota Maria Cristina , Del Manso Martina , Urdiales Alberto Mateo , Andrianou Xanthi , Fabiani Massimo , Boros Stefano , Vescio Fenicia , Riccardo Flavia , Bella Antonino , Filia Antonietta , Rezza Giovanni , Villani Alberto , Pezzotti Patrizio ,   COVID-19 WORKING GROUP
Published: July 2020

OBJECTIVES:

To describe the epidemiological and clinical characteristics of coronavirus disease (COVID-19) pediatric patients aged <18 years in Italy.

METHODS:

Data from the national case-based surveillance system of confirmed COVID-19 infections until May 8, 2020, were analyzed. Demographic and clinical characteristics of subjects were summarized by age groups (0–1, 2–6, 7–12, 13–18 years), and risk factors for disease severity were evaluated by using a multilevel (clustered by region) multivariable logistic regression model. Furthermore, a comparison among children, adults, and elderly was performed.

RESULTS:

Pediatric patients (3836) accounted for 1.8% of total infections (216 305); the median age was 11 years, 51.4% were male, 13.3% were hospitalized, and 5.4% presented underlying medical conditions. The disease was mild in 32.4% of cases and severe in 4.3%, particularly in children ≤6 years old (10.8%); among 511 hospitalized patients, 3.5% were admitted in ICU, and 4 deaths occurred. Lower risk of disease severity was associated with increasing age and calendar time, whereas a higher risk was associated with preexisting underlying medical conditions (odds ratio = 2.80, 95% confidence interval = 1.74–4.48). Hospitalization rate, admission in ICU, disease severity, and days from symptoms onset to recovery significantly increased with age among children, adults and elderly.

CONCLUSIONS:

Data suggest that pediatric cases of COVID-19 are less severe than adults; however, age ≤1 year and the presence of underlying conditions represent severity risk factors. A better understanding of the infection in children may give important insights into disease pathogenesis, health care practices, and public health policies.