bluuebunny/crossref_metadata_2025 huggingface dataset:
Writing strategies by beginning authors of academic genre
Authors: Syahid Abdul
Published: April 2019

Aimed at identifying what writing strategies four beginning authors used and examining how these strategies facilitated their writings, a collective case study describing and comparing the beginning authors was carried out to provide insights into the issue. The authors were teachers of English in English departments at four Indonesian universities, and were selected on the basis of a recommendation by the editor of some books in which their written products were published. To gain a far better understanding of the cases, two data forms (questionnaires and interview notes) were collected. The data gathered were repeatedly examined in order to discover some reoccurring patterns. The inductive process delineated the strategies used by the participants when dealing with academic writing. The results show that, in order of priority, the writing strategies employed in their initial writing careers were social, affective, compensation, and cognitive ones. This study contributes to the knowledge of social or contextual factors in writing English academic papers by illustrating which strategies were used and how in order to cope with the writing process. It also suggests writing strategies be adopted by future authors and built in the classes of English as a foreign language.
Factors hindering Indonesian lecturers from publishing articles in reputable international journals
Authors: Arsyad Safnil , Purwo Bambang Kaswanti , Sukamto Katharina Endriati , Adnan Zifirdaus
Published: April 2019

The purpose of this study is to investigate the possible factors inhibiting the university lecturers or professors in Indonesia from publishing their research results in reputable international journals in English. The research used a mixed (quantitative and qualitative) method, employing a national survey and in-depth interviews with selected lecturers and researchers in five different universities in Indonesia (i.e., Bengkulu University, Padang State University, Makasar State University, Unika Atma Jaya University and Mataram University). The results show that three main factors have hindered the lecturers from submitting their articles to reputable international journals: lack of self-confidence on the quality of their own research and article, finding it very difficult and very time consuming to prepare an article in English and no adequate reward for those who can successfully publish in reputable international journals. However, the majority of them have a positive attitude toward international journal publication for their own benefits or for the sake of their institution.
Que matemática para formar o futuro professor? História do saber profissional do professor que ensina matemática
Authors: Valente Wagner Rodrigues
Published: April 2019

Este texto é resultado sistematizado da conferência de abertura que foi proferida na II Escola de Estudos Avançados Sobre Pesquisa em Cultura, História e Educação Matemática. O evento ocorreu em Belém do Pará, na UFPA, entre os dias 4 a 8 de fevereiro de 2019. Foi promovido pelo Programa de Pós-Graduação em Educação em Ciências e Matemática, em parceria com o GHEMAT Brasil – Associação de Pesquisadores em História da Educação Matemática.
História para a educação matemática: apontamentos sobre as pesquisas brasileiras
Authors: Mendes Iran Abreu
Published: April 2019

Diversas pesquisas relativas às conexões entre história e educação matemática no Brasil têm gerado importantes resultados que apontam temáticas, fundamentações epistemológicas, abordagens metodológicas e experimentações didáticas que podem contribuir para a formação de professores que ensinam matemática. Durante uma década (2008-2018) desenvolvi uma pesquisa sobre a produção científica brasileira nessa área, considerando as dimensões histórico-epistemológica, pedagógica e histórico-educacional. Neste artigo, faço uma descrição comentada dos resultados obtidos na pesquisa, tomando base em questões como: Qual o formato epistemológico das pesquisas sobre história da educação matemática? De qual pesquisa se trata? Que histórias são focalizadas nas pesquisas sobre história da educação matemática? De que maneira essas histórias são produzidas por pesquisadores, quais seus significados pedagógicos e até que ponto podem ser utilizadas pelos professores de Matemática em suas aulas? Minhas indagações foram fundamentadas em autores como Michel Serres (2008), Ludwick Fleck (2010), Mauro Condé (2012), Bruno Latour (1994; 2000), Peter Burke (2016) e Maurice Caveing (2004), para situar os campos em que essas pesquisas estão localizadas, propor sua inserção na formação de professores que ensinam Matemática e apresentar uma agenda de trabalho a ser implementada como política de formação conceitual e didática de professores que ensinam matemática. Palavras-chave: História e Educação Matemática. Pesquisa histórica. Metodologia da pesquisa.
O professor leigo que ensinava matemática no sul do Mato Grosso (década de 60 do século XX): história da sua formação
Authors: Furtado Alessandra Cristina , Alencar Edvonete Souza de , Amorim Rômulo Pinheiro de
Published: April 2019

Este artigo analisa a história da formação dos professores que ensinavam Matemática, de 1ª a 4ª séries, em escolas situadas no meio rural no Sul de Mato Grosso, no município de Dourados, na década de 1960. Para tanto, focalizamos a formação de uma professora leiga que fez o Curso de Regentes, no Centro de Treinamento do Magistério de Cuiabá, no ano de 1969. O trabalho foi realizado por meio de pesquisa documental, tomando dois Cadernos, ligados ao ensino da Matemática da professora investigada, bem como, de outros documentos. Além disso, foi necessário recorrer aos referenciais da história, história da educação, história da educação matemática. Os resultados apontaram que a formação de professores, recebida nesse Centro de Treinamento do Magistério de Cuiabá, era dada no passo a passo, no sentido do como fazer, sendo um curso de rápida formação docente. Contudo, a formação dada no ensino da Matemática era influenciada pelo Movimento da Matemática Moderna. Conclui-se assim, que esse movimento influenciou a história da formação dos professores primários leigos que ensinavam Matemática, que frequentaram os cursos oferecidos pelo Centro de Treinamento do Magistério de Cuiabá. Palavras-chave: Formação de Professores Leigos. Ensino de Matemática. Movimento da Matemática Moderna.
Uma história do PIBID contada por estudantes do curso de licenciatura em matemática
Authors: Santos José de Aquino , Gomes Larissa Pinca Sarro
Published: April 2019

A formação de professores é uma temática circunscrita em contextos permeados por muitas discussões. Neste artigo, considerando o Programa Institucional de Bolsas de Iniciação à Docência como um espaço significativo para a formação de professores, apresentamos algumas atividades evidenciadas pelos estudantes de iniciação à docência, do curso de Licenciatura em Matemática, que podem trazer contribuições para sua formação. Participaram desta pesquisa, cinco estudantes bolsistas de iniciação à docência de um subprojeto do PIBID, desenvolvido em uma instituição pública de ensino superior, localizada no extremo sul da Bahia, no período de 2011 a 2014. Utilizamos a metodologia da História Oral para a produção de fontes escritas, privilegiando os relatos orais dos estudantes. Também consideramos documentos escritos que nos ajudaram a compreender como aconteceu a articulação entre a instituição de ensino superior e as escolas. Foi possível perceber que as ações realizadas no âmbito desse programa proporcionaram aos estudantes a mobilização e produção de saberes docentes, a partir do estudo de diferentes metodologias para o planejamento de materiais didáticos, dos momentos de reflexão a respeito da trajetória educacional dos estudantes, do trabalho realizado em sala de aula com os alunos da Educação Básica e da divulgação de suas experiências. Palavras-chave: Formação de professores. Programa Institucional de Bolsas de Iniciação à Docência. História Oral.
Roberto Moreira, aulas particulares e o ensino de aritmética no século XIX
Authors: Soares Waléria de Jesus Barbosa
Published: April 2019

Apresentamos uma investigação sobre Roberto Antonio Moreira, maranhense, professor e autor de livros de matemática, que viveu na cidade de São Luís, no século XIX. Através de sua história de vida, objetivamos construir um texto biográfico, até onde os dados permitiram resgatar, além de tecer considerações sobre sua vida profissional envolvida pela publicação de suas obras. O presente texto, de metodologia qualitativa, constitui uma pesquisa de abordagem documental, que utiliza fontes primárias dos arquivos da Biblioteca Pública Benedito Leite, do Arquivo Público do Estado do Maranhão e do Liceu Maranhense. Estamos pautados teoricamente, em Bittencourt (2004), Ferrarotti (2010), Morais (2017), Paulilo (1999) e Valente (2008). Acreditamos que descortinar histórias de vida de autores de livros de matemática aproxima-nos do entendimento de como se construiu o ensino de matemática no local e tempo investigados – contribuindo, portanto, para compor um quadro do Brasil. Palavras-chave: História de vida. História de vida profissional. Professor de matemática.
A escola de todas as cores: o papel do gestor escolar no combate ao racismo
Authors: Araújo Helena de Lima Marinho Rodrigues , Braga Aline Cristina Clemente
Published: April 2019

O racismo é um tema ainda bastante discutido sob vários enfoques: sociológico, antropológico, filosófico, educacional, entre outros. A escola é um lócus por excelência para o debate e propostas de mudanças para disseminar o conhecimento e a necessidade de priorizar o direito de todos viverem bem no mundo. Este artigo teve por objetivo conhecer o papel do gestor escolar no combate ao racismo nos anos iniciais do Ensino Fundamental. As referências teóricas utilizadas para respaldar a análise dos dados foram focadas em artigos científicos, documentos e livros, destacando os seguintes autores: Macedo (2014), Pereira (2012), Rodrigues (2011) e Schucman (2010). Elegeu-se a análise qualitativa dos dados, por meio de entrevista semiestruturada com uma coordenadora de uma escola pública e uma diretora de uma escola privada, sendo essas instituições localizadas em um mesmo bairro do município de Fortaleza, no estado do Ceará. As entrevistas revelaram que o tema racismo é tratado com o diálogo e que há a participação da gestão para a resolução de problemas, tendo-se ciência dos recursos disponíveis para trabalhar o tema. De outro ângulo, mostraram pouca desenvoltura no tocante às leis e aos trabalhos com projetos nas escolas que abordem o racismo de forma mais constante como parte do currículo escolar. Palavras-chave: Preconceito racial. Gestão escolar. Ensino-aprendizagem.
Letramento crítico na sociedade digital
Authors: Silva Cleisiane de Sousa
Published: April 2019

“Letramentos na sociedade digital: navegar é e não é preciso” é uma obra que traz o estudo sobre as novas formas de navegação dos jovens na internet. Baseia-se em concepções recentes sobre letramentos e multiletramentos, principalmente letramentos críticos, como práticas sociais. A autora é Nara Hiroko Takaki, possui 3 capítulos e compõe-se de 228 páginas. Essa obra faz parte da Paco Editorial e sua primeira edição foi no ano de 2012, em Jundiaí - SP. Este livro é uma versão um pouco modificada da tese de doutorado de Nara, traz novas epistemologias em meio à construção complexa de conhecimento em rede. A pesquisadora analisou os posicionamentos de uma comunidade de discentes universitários, de como interpretam materiais virtualmente produzidos ou veiculados, pela observação de mensagens enviadas por eles utilizando o site http//:www.webnarah.pro.br/old, site criado para uma investigação de como os hiperleitores constroem saberes a partir de suas interações com os textos virtuais.
QUAND L’INTERDISCIPLINARITE S’IMPOSE : CONTOURNEMENT D’UN REFUS DE TERRAIN PAR LA PROSOPOGRAPHIE
Authors: DEMONTEIL Marion
Published: April 2019

When Interdisciplinarity Seems the Right Thing to Do: Overcoming Rejection from the Field Through Prosopography. This paper addresses the practical modalities of entry into interdisciplinarity. Starting from a specific case of rejection from the field, it shows how the use of the historical discipline’s tools shapes the construction of a sociological research object. Following a rejection from the field, this research had to get historical distance, which lead our study from a questioning on the effects of new public management to a socio-history of administrative control at the crossroads of history and the sociology of action. The exploratory possibilities offered by prosopography, and more specifically by optimal matching, are illustrated from the material of a survey devoted to the general inspectors of the French ministry of Culture between the 1960s and today.
COMMUNAUTES EPISTEMIQUES ET INTERDISCIPLINARITE : LA GESTION DES CRISES ASSOCIEES AUX ALEAS TELLURIQUES, ENTRE SCIENCES DE LA TERRE ET SCIENCES POLITIQUES
Authors: DEVÈS Maud H. , RIBÉMONT Thomas
Published: April 2019

Interdisciplinarity and Epistemic Communities: Crisis Management and Telluric Hazards, Between Life Sciences and Political Science. In an interdisciplinary perspective, between earth sciences and political sciences the present article shows that the concept of epistemic communities, frequently used by political scientists specializing in the sociology of public policy, says very little about the inner workings of the scientific field. This article shows that the concept of epistemic community tends to mask the complexity of the situation of expertise to highlight this point, we chose to study three cases of crisis management associated with the same type of hazard, of volcanic origin, which reveal the difficulties related to various levels of interdisciplinarity. The first crisis studied here is related to the eruption of La Soufrière volcano on Guadeloupe in 1976. This event gives a picture of various epistemological positions within the same discipline, i.e. the earth sciences of the Earth, and illustrates their possible consequences in the public sphere. The second crisis is related to the eruption of the Soufrière Hills Volcano on Montserrat (1995 and ongoing). Although the experts are again drawn from the earth sciences, they represent different specialities. We find that the experts knew how to make use of probabilistic tools to overcome the difficulties related to uncertainties inherent in the crisis and, beyond that, arising from the incompleteness of their knowledge. Lastly, we discuss the crisis related to the eruption of the Icelandic volcano Eyjafjallajökull in 2010. In this last case, the composite nature of the hazard required us to call upon experts from two different disciplines: the earth sciences and atmospheric sciences. Specialization appears here as a factor of vulnerability. Indeed, the crisis confronts the experts with a mismatch between their approaches and makes it difficult to develop an opinion that fully benefits from their different types of expertise.
I RAPPORTI DIPLOMATICI TRA ROMANIA E ITALIA NEGLI ANNI VENTI, 1920-1928
Authors: RUS Maria-Ioana
Published: April 2019

Diplomatic Relations between Romania and Italy Between 1920-1928. The consequences of the First World War marked the history of mankind to the extent that the people most affected by it did not believe in peace. The Paris Peace Conference was an event of great historical significance which left a deep scar in the consciousness of human kind. Romanian-Italian relations during the Paris Peace Conference will be of great influence in the years to come. This article will analyze Romania's struggle for the annexation of Bessarabia after the end of the First World War, highlighting the transformations on political and social levels. Will Romania succeed in obtaining ratification by Italy of the Protocol on Bessarabia, which ultimately represents the price of peace?
Las expresiones de los estudiantes de instituciones de nivel superior en torno a las personas con discapacidad
Authors: García Reyes Jesús
Published: April 2019

La investigación es una aproximación al problema de la exclusión hacia las personas con discapacidad por parte de estudiantes de Instituciones de Educación Superior del país. Se elaboró un instrumento basado en la asociación de palabras para luego utilizar la técnica de redes semánticas naturales a una muestra de 519 estudiantes de nueve Instituciones de Educación Superior en México para conocer las expresiones sobre el tema de la discapacidad empleando una palabra generadora de uso cotidiano. Aunque los hallazgos evidencian aceptación aún prevalecen los estigmas y la desinformación que pueden llevar a la discriminación.
Response and outcome following toceranib phosphate treatment for stage four anal sac apocrine gland adenocarcinoma in dogs: 15 cases (2013–2017)
Authors: Elliott James W.
Published: April 2019

OBJECTIVE

To assess response and outcome in dogs with stage 4 anal sac apocrine gland adenocarcinoma (ASAGA) treated with toceranib phosphate as the sole chemotherapeutic agent.

DESIGN

Retrospective case series.

ANIMALS

15 client-owned dogs with stage 4 ASAGA treated with toceranib phosphate between March 2013 and June 2017.

PROCEDURES

Medical records were reviewed, and data collected included signalment, clinical signs, results of physical examinations and diagnostic procedures, treatments, response, follow-up information, and outcomes. Adverse events and response to treatment were assessed according to standard guidelines, and the Kaplan-Meier product limit method was used for analyses of progression-free interval and survival time.

RESULTS

No dogs had a complete or partial response to treatment with toceranib; however, 13 dogs had signs of clinical benefit. No dogs had signs of toxic effects related to toceranib or were withdrawn completely from treatment because of adverse events. Median progression-free interval and median survival time were 354 and 356 days, respectively.

CONCLUSIONS AND CLINICAL RELEVANCE

Results of the present study indicated that dogs with stage 4 ASAGA treated with toceranib had improved outcomes, compared with outcomes previously reported for dogs with ASAGA that had received non–tyrosine kinase inhibitor treatments. Some dogs had improvement in clinical signs, but euthanasia was often performed because of signs of locoregional failure; therefore, toceranib alone may not be an appropriate treatment for dogs with marked clinical signs attributed to ASAGA, particularly when signs suggest limited quality of life. Further study of toceranib in multimodality treatments for dogs with advanced ASAGA is warranted.
PENERAPAN ALGORITMA APRIORI DALAM MENENTUKAN POLA PEMBELIAN KONSUMEN DI KAFE HIDDEN TOAST AND FLOAT
Authors: Rismanto Ridwan , Darmawan Lucki , Prasetyo Arief
Published: April 2019

Progress in Information Technology encourages culinary businesses to innovate, one of them is a computerized system, online-based sales and several interesting features that can increase consumer interest and increase sales to be the most frequently used innovation today. The cafe "Hidden Toast and Float" is a cafe in the City of Kediri. To increase sales from the cafe, a system is needed to facilitate the owner in recording sales and increasing the number of sales by providing automatic menu recommendations to customers. Based on the problem, in this thesis a website-based sales system and sales system will be created that is accompanied by the application of a priori algorithm to determine the purchasing patterns of customers and automatic menu recommendations from the system for customers. The test results of this thesis are two website-based systems with admin systems used to process existing data on the database and customer websites that are used for online purchases, as well as the application of a priori algorithms with the results of testing sample data and real data that produce menu combination recommendations. most often purchased based on all transaction data, namely Dark Choco Jam and Cappucino with a support value of 15% and a confidence value of 45%.
PENGELOMPOKAN KEJADIAN GEMPA BUMI MENGGUNAKAN FUZZY C-MEANS CLUSTERING
Authors: Arista Ryan Rifqi , Asmara Rosa Andrie , Puspitasari Dwi
Published: April 2019

The Indonesian region has a high level of earthquake vulnerability when compared to other countries. This is because Indonesia's position is at the confluence of three large tectonic plates namely the Eurasian plate, the Indo-Australian plate, and the Pacific plate. The high level of earthquake susceptibility is evidenced by significant earthquake data from 2005 to 2009, which recorded 26 significant earthquakes over a period of 4.8 to 8.6 on the Richter scale. The earthquake also caused impacts including casualties, injuries, damage to houses and destruction of houses.The earthquake event grouping system is a system that functions to classify earthquake events based on two main parameters, namely earthquake strength parameters and earthquake impact parameters. The two parameters are grouped separately, so that the grouping process produces two kinds of grouping results. The stages of this system start from preprocessing data to eliminate noise, then take grouping parameters from the user in the form of the number of clusters, minimum error values, and the maximum iteration limit. Grouping is done using fuzzy c-means method. The grouping results are then displayed in table form and in the form of coordinates in Google Maps.The grouping of earthquake events has been tested by comparing the results of grouping systems with the results of manual grouping. Testing is done by inputting a number of different maximum iterations. Based on the test results it was found that the greater the maximum iteration value will affect the accuracy of grouping.
SISTEM PEMANTAUAN KONSENTRASI CO KEBAKARAN HUTAN RIAU MENGGUNAKAN TEKNOLOGI WIRELESS SENSOR NETWORK (WSN) DAN INTERNET OF THINGS (IOT)
Authors: Prayitno Eko , Amirullah Desi
Published: April 2019

The purpose of this research is how to make an air condition monitoring system by considering the concentration value of carbon monoxide in Riau Province. The technology used to support monitoring system of carbon monoxide concentration, using Wireless Sensor Network Technology (WSN) and Internet of Things (IoT). One of the WSN concepts to be used is a combination of several sensors, the only sensors used to detect the level of carbonmonoxide concentration include: carbon monoxide, temperature and humidity sensors. Air condition data derived from the sensor in the form of concentration value of carbon monoxide, temperature and humidity of air sent to server connected to network using IoT technology. Based on the test results it can be concluded that the air condition monitoring system using WSN and IoT technology can be applied in realtime, this can be proven with the data shown in the monitoring tool. the detection of a fire source using a sensor can be done by using a distance between a smoke source (hotspot) and a device 90cm. From the observation result there is difference between sensing data without smoke and using smoke, such as temperature has 60C difference, humidity 20 rh and carbon monoxide about 17ppm
Autoimagem e estigma social na doença falciforme: uma revisão integrativa
Authors: Barberino Isnaile Alves , Coelho Tércia Oliveira , Duque Caroline Borges , Silva Emanuela Cardoso da , Rocha Roseanne Montargil
Published: April 2019

Objetivo: Analisar o estigma social e a autoimagem da pessoa com doença falciforme (DF) à luz da literatura científica nacional e internacional. Método: Pesquisa Baseada em Evidência (PBE) a partir da revisão integrativa da literatura, com organização do trabalho em seis etapas priorizando a estrutura basilar da PBE expressa pela sigla PICO, a saber, População, Interesse, Comparação, Outcomes. As bases de dados eletrônicas consultadas foram SciELO, MEDLINE, CUMED e LILACS, no período de 2013 à janeiro de 2018 e as palavras-chave são originadas do Descritores em Ciências da Saúde. Resultados: Os estudos demonstraram que a pessoa com DF tem dificuldades para conviver socialmente devido a limitação de informações acerca da patologia pelos familiares e demais atores sociais; e adolescentes tem buscado diferentes estratégias para enfrentar o preconceito e desenvolver a autoestima. Conclusão: A discussão de questões psicossociais que envolvam a pessoa com DF foi percebida discretamente na literatura nos últimos cinco anos. Todavia, a assistência integral, ressaltando os aspectos psicossociais, requer um esforço da sociedade, desmistificando conceitos, e multiprofissional, na qualidade do serviço e no investimento em pesquisa e divulgação dos achados.
Observation of chemo-mechanical failure and influence of cut-off potentials in all-solid-state Li-S batteries
Authors: Ohno Saneyuki , Dewald Georg , Koerver Raimund , Rosenbach Carolin , Titscher Paul , Steckermeier Dominik , Kwade Arno , Janek Juergen , Zeier Wolfgang
Published: April 2019

Owing to a remarkably high theoretical energy density, the lithium-sulfur (Li-S) battery has attracted significant attention as a candidate for next-generation batteries. While employing solid electrolytes can provide a new avenue for high capacity Li-S cells, all-solid-state batteries have unique failure mechanisms such as chemo-mechanical failure due to the volume changes of active materials. In this study, we investigate all-solid-state Li-S model cells with differently processed cathode composites and elucidate a typical failure mechanism stemming from irreversible Li2S formation in the cathode composites. Reducing the particle size is key to minimizing the influence of volume changes and a capacity of over 1000 mAh gsulfur-1is achieved by ball-milling of the cathode composites. In addition, the long-term stability of the ball-milled cathode is investigated by varying upper and lower cut-off potentials for cycling, which results in unveiling the significantly detrimental role of the lower cut-off potential. Preventing a deep-discharge leads to a reversible capacity of 800 mAh gsulfur-1over 50 cycles in the optimized cell. This work highlights the importance of mitigating chemo-mechanical failure using microstructural engineering as well as the influence of the cut-off potentials in all-solid-state Li-S batteries.
A Chemical Perspective to the Anti-Amyloid Action of Compounds and a Nanoparticle Based Assay for Screening Amyloid Inhibitors
Authors: Gour Nidhi , Koshti Bharti , kanth P chandra , Kshtriya Vivek Shinh , pandey Manoj kumar
Published: April 2019

Aggregation of amyloid beeta 1-42 (Aβ42) peptide causes the formation of clustered deposits knows as amyloid plaques in the brain which leads to neuronal dysfunction and memory loss and associated with many neurological disorders including Alzheimer’s and Parkinson’s. Aβ42 has core structural motif with phenylalanine at the 19 and 20 positions. The diphenylalanine (FF) residue plays a crucial role in the formation of amyloid fibers and serves as model peptide for studying Aβ42 aggregation. FF self-assembles to well-ordered tubular morphology via aromatic pi-pi stackings. Our studies, suggest that the aromatic rings present in the anti-amyloidogenic compounds may interact with the pi-pi stacking interactions present in the FF. Even the compounds which do not have aromatic rings, like cyclodextrin and cucurbituril show anti-amyloid property due to the binding of aromatic ring inside the guest cavity. Hence, our studies also suggest that compounds which may have a functional moiety capable of interacting with the aromatic stacking interactions might be tested for their anti-amyloidogenic properties. Further, in this manuscript, we have proposed two novel nanoparticle based assays for the rapid screening of amyloid inhibitors. In the first assay, interaction between biotin-tagged FF peptide and the streptavidin labelled gold nanoparticles (s-AuNPs) were used. In another assay, thiol-Au interactions were used to develop an assay for detection of amyloid inhibitors. It is envisaged that the proposed analytical method will provide a simple, facile and cost effective technique for the screening of amyloid inhibitors and may be of immense practical implications to find the therapeutic remedies for the diseases associated with the protein aggregation.
Relative Rates of Bond Rotation and Ring Closure in the Photocycloaddition Intermediates from Fullerene-C60 and the Isomeric 2,4-Hexadienes
Authors: Dilling Wendell
Published: April 2019

Photocycloaddition of fullerene-C60 to the isomeric 2,4-hexadienesreported by Orfanopoulos and co-workers gave a series of 2 + 2 cycloadducts in which bond rotation had occurred in some products. Relative rates of bond rotation and ring closure in the biradical intermediates were calculated from the product distributions using equations developed by Bartlett and co-workers. These data are reinterpreted to show that the ratio of the rate of bond rotation in the intermediate to the rate of ring closure to the cyclobutane product is ~70 for the trans-1-propenyl intermediate formed in the initial cis conformation. Data are inconsistent for the analogous cis-1-propenyl intermediate. The relative rate for the trans-1-propenyl intermediate formed in the initial trans conformation is ~9. Accurate relative rate determinations are highly dependent on very accurate product distribution determinations.
Flow Chemistry Controls Both Self-Assembly and the Entrapped Oscillatory Cargo in Belousov-Zhabotinsky Driven Polymerization-Induced Self-Assembly
Authors: Hou Liman , Dueñas-Diez Marta , Srivastava Rohit , Perez-Mercader Juan
Published: April 2019

Belousov-Zhabotinsky (B-Z) reaction driven polymerization-induced self-assembly (PISA), or B-Z PISA, is a novel method for the autonomous one-pot synthesis of polymer vesicles from a macroCTA (macro chain transfer agent) and monomer solution (“soup”) containing the above and the BZ reaction components. In it, the polymerization is driven (and controlled) by periodically generated radicals generated in the oscillations of the B-Z reaction. These are inhibitor/activator radicals for the polymerization. Until now B-Z PISA has only been carried out in batch reactors. In this manuscript we present the results of running the system using a continuously stirred tank reactor (CSTR) configuration which offers some interesting advantages.Indeed, by controlling the CSTR parameters we achieve reproducible and simultaneous control of the PISA process and of the properties of the oscillatory cargo encapsulated in the resulting vesicles. Furthermore, the use of flow chemistry enables a more precise morphology control and chemical cargo tuning. Finally, in the context of biomimetic applications a CSTR operation mimics more closely the open non-equilibrium conditions of living systems and their surrounding environments.
Characterization of reactive organometallic species via MicroED
Authors: Jones Christopher , Asay Matthew , Kim Lee Joon , Kleinsasser Jack , Saha Ambarneil , Fulton Tyler J. , Berkley Kevin , Cascio Duilio , Malyutin Andrey , Conley Matthew , Stoltz Brian M. , LaVallo Vincent , Rodriguez Jose A. , Nelson Hosea
Published: April 2019

Here we apply microcrystal electron diffraction (MicroED) to the structural determination of transition metal complexes. We find that the simultaneous use of 300 keV electrons, very low electron doses, and an ultra-sensitive camera allows for the collection of data without cryogenic cooling of the stage. This technique reveals the first crystal structures of the classic zirconocene hydride, colloquially known as “Schwartz’s reagent”, a novel Pd(II) complex not amenable to solution-state NMR or X-ray crystallography, and five other paramagnetic or diamagnetic transition metal complexes.
Клинический случай лечения метастатической липосаркомы нижней конечности
Authors: Седаков И. Е. , Семикоз Н. Г. , Пивоваров Р. А. , Комендант В. В. , Ползиков Г. П. , Гандера В. Ф.
Published: April 2019

В статье приводятся литературные данные о редко встречающемся у взрослых заболевании — веретеноклеточной липосаркоме нижней конечности. Так же приводится клинический случай данного заболевания у женщины.
Отдаленные результаты лечения больных раком толстой кишки с инвазией в мочевой пузырь после комбинированных резекций
Authors: Башеев В. Х. , Балабан В. В. , Бондаренко Н. В. , Давуд Аль , Понсе А. О.
Published: April 2019

Цель. Проанализировать отдаленные результаты лечения больных раком толстой кишки с инвазией в мочевой пузырь. Определить независимые факторы, которые влияют на выживаемость.Материалы и методы. В исследование были включены 330 пациентов за 30-летний период c 1986 по 2015 годы, которые получили оперативное лечение по поводу злокачественных опухолей толстой кишки с инвазией в мочевой пузырь (Т3–4, N0–2, M0–1, классификация ТNM 6-е издание). В исследование не включались больные с первой стадией, а также после эвисцерации органов малого таза.Результаты. 5-летняя общая выживаемость при раке толстой кишки с инвазией в мочевой пузырь составила 52,7% (95% ДИ 46,9–59,2), безрецидивная выживаемость — 49,5% (95% ДИ 43,8% — 56%). Местный рецидив был отмечен у 22 (6,7%), отдаленные метастазы — 21 (6,4%) больного, причем сочетание местного и метастатического продолжения болезни было зафиксировано в 4 (1,2%) случаях. Медиана безрецидивной выживаемости составила 58 (95% ДИ 44–78) месяцев. При мультивариантном анализе были найдены следующие независимые факторы, которые влияют на выживаемость: возраст, пол, ССI, тип операции, послеоперационные осложнения, степень дифференцировки опухоли, резекция дополнительного органа, истинная инвазия опухоли.Выводы. 5-летняя выживаемость может быть увеличена при выполнении радикальной операции, снижении частоты послеоперационных осложнений и «экономной резекции» при соблюдении R0 границ.
Detecting Toxic Content Online and the Effect of Training Data on Classification Performance
Authors: Zhao Zhixue , Zhang Ziqi , Hopfgartner Frank
Published: April 2019

The spread of toxic content online has attracted a wealth of research into methods of automatic detection and classification in recent years. However, two limitations still exist: 1) the lack of support for multi-label classification; and 2) the lack of understanding of the impact of the typical unbalanced datasets on such tasks. In this work, we build three state of the art methods for the task of multi-label classification of toxic content online, and compare the effect of training data size on their performance. The three methods of choice are based on Support Vector Machine (SVM), Convolutional Neural Networks (CNN) and Long-Short-Term Memory Networks (LSTM), respectively. We conduct learning curve analysis and show that CNN is the most robust method as it outperforms the other two regardless of the sizes of the dataset, even on very small amounts of data. This challenges the conventional belief that Neural Networks require significant amounts of data to train accurate models. We also empirically derive indicative thresholds of training data size to help determine a reliable estimate of classifier performance, or maximise potential classifier performance in such tasks.
Chemotherapy Regimen and Incidence of Malnutrition after Chemotherapy in Non-small Cell Lung Cancer
Authors: Buntitabhon Sirichancheun  , Jantanee Thanomsakcharoen  , Piyanuch Intakut  , Yaowapan Kaewpan    , Chuleegone Sornsuvit
Published: April 2019

Lung cancer is the leading cause of death worldwide and in Thailand. The treatment of non-small cell lung (NSCLC) with chemotherapy might affected on nutritional status which could correlate with the treatment response and quality of life. Thus, the objectives of this research were to study the nutritional status of patients after chemotherapy and the incidence of malnutrition. This retrospective longitudinal descriptive study was gathering the information from medical records January, 2013 to December, 2014. A 114 patients were met the inclusion criteria which were completed 4 or 6 cycles of treatment. Body mass index (BMI) and percentage of weight loss were used to assess the nutritional status. Malnutrition was classified when BMI under 18.5 kg/m2 and weight change more than 5%. The average age, baseline weight and BMI were 60.4±10.1 year, 55.0±9.0 kg and 22.0±2.5 kg/m2, respectively. The incidence of malnutrition was 6.1%. Mean BMI decreased from 22.0 kg/m2 to 21.5 kg/m2 after chemotherapy. Patients treated with carboplatin plus paclitaxel showed the highest change of BMI (-0.6 kg/m2) and docetaxel regimen showed the highest incidence of malnutrition (18.8%). According to the base agents; taxane-based regimen showed the most effect on nutritional status and 85% of those patients were malnutrition. In conclusion, docetaxel and carboplatin plus paclitaxel highly affected on nutritional status. In patients treated with those regimens, they should be closely monitored and gave an adequate nutritional advice for the better treatment response, decrease the side effect from chemotherapy and improve patients’ quality of life.
Diagnosis and Treatment of Chronic Heart Failure in Diabetes of the 2nd Type
Authors: M.S. Kultayev  , A.Zh. Yesirkepova  , A.B. Abdugulova  , A.B. Abdykulova  , B.Zh. Kanseitova
Published: April 2019

Chronic heart failure (CHF) is an acute medical and social problem relating to the priorities of the national health systems of most countries of the world due to the increasing spread of this syndrome, despite the continuous improvement of treatment. The near future promises only the worsening of the problem: the incidence and prevalence of CHF increases due to the increase in life expectancy.Thus, the need to clarify the features of the diagnosis of CHF in patients with diabetes mellitus and the improvement of their therapy is beyond doubt.The aim of this research is to clarify the frequency of chronic heart failure in patients with diabetes type 2 in the specialized | department of the hospital and the unorganized urban population, to assess the adequacy of its diagnosis and treatment.To achieve this goal, the following tasks:1. To identify the prevalence of chronic heart failure in patients with diabetes type 2.2. To assess the level of diagnosis of chronic heart failure in patients with diabetes type 2.3. To analyze the state of drug therapy in patients with diabetes type 2 in the presence of chronic heart failure.For the first time, the prevalence of CHF in patients with diabetes type 2 mellitus in an unorganized urban population studied.
Effect of Grinding the Herb and Boiling the Infusion on Total Phenolic Content and Antioxidant Capacity of Herbal Infusions
Authors: Karam Kharobi    , Lina Soubh
Published: April 2019

Herbal infusions are one of the most consumed beverages in the world. The object of this work was to estimate the phenolic content and evaluate the antioxidant capacity of Cumin seeds (Cuminum cyminum L.) and Anise seeds (Pimpinella anisum L.) infusions, and study the effect of grinding the herb and boiling the infusion on that. The total phenolic content (TPC) was determined by Folin-Ciocalteu method, and the antioxidant capacity was evaluated by two methods, DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging assay and FRAP (ferric reducing antioxidant power) assay. The TPC and antioxidant activity have increased by grinding the herb and boiling the infusion. By grinding, the TPC and antioxidant activity have nearly multiplied.
Empresas mexicanas del sector de la transformación que cotizan en Bolsa, su vulnerabilidad financiera ante una crisis financiera
Authors: Andrade Vallejo María Antonieta , Marcelino Aranda Mariana
Published: April 2019

RESUMENLas crisis financieras derivadas de las especulaciones de los agentes financieros puso de manifiesto la creciente inestabilidad de los flujos de capital, por lo que el presente trabajo establece la relación que existe entre la conformación de la estructura financiera en las empresas mexicanas del sector de la transformación que cotizan en bolsa, y los cambios de la TIIE1. Lo cual permite tomar decisiones sobre el porcentaje en que las empresas habrán de financiarse a través de pasivos, en función del costo del dinero presente y futuro y de las expectativas que tienen los agentes financieros sobre la situación económica del país. Finalmente los resultados indicaron que en el caso de Herdez y Kimberly, su situación es de vulnerabilidad ante las condiciones económicas globales y particularmente las que se presentan en México.Palabras clave: estructura financiera, crisis financiera, empresas mexicanas del sector de la transformación, agentes financieros, financiamiento. Companies Mexicans in the processing sector that is publicly traded, its financial vulnerability to financial crisis.ABSTRACTThe financial crisis resulting from speculation by financial players highlighted the increasing volatility of capital flows, as this paper establishes the relationship between the conformation of the financial structure of Mexican companies, sector quoted transformation, and changes TIIE. This enables decisions about the percentage that companies be financed through liabilities, cost of money present and future and the expectations that financial officials on the economic situation. Finally, the results indicated that in the case of Herdez and Kimberly, their position is vulnerable to global economic conditions, particularly those occurring in Mexico.Keywords: financial structure, financial crisis, processing sector, brokers, finance.
Modelo geométrico para optimizar el adiestramiento de los administradores en el sector industrial farmacéutico de Puerto Rico
Authors: López Moreno Walter , Márquez Eulalia , Guzmán Josué , Colón Pablo A.
Published: April 2019

RESUMENEste estudio trata acerca del desarrollo de un modelo funcional para diagnosticar el sistema de aprendizaje óptimo en los adiestramientos dentro de la industria farmacéutica. Los resultados sugieren que: 1) los administradores en la industria farmacéutica prefieren un sistema de adiestramiento bajo un método de aprendizaje específico, 2) un subgrupo de administradores no muestra preferencia por un método de aprendizaje no tradicional, individual y empírico, 3) existen diferencias entre dos subgrupos de administradores para un sistema de adiestramiento bajo un método de aprendizaje específico, y 4) no existen diferencias estadísticamente significativas en las preferencias por género por un sistema de adiestramiento bajo un método de aprendizaje en específico.Palabras clave: gestión de personal, administración, adiestramiento, aprendizaje. Geometric model to optimize the managers’ training in the pharmaceutical industrial sector of Puerto RicoABSTRACTThis study addresses the development of a functional model to diagnose the optimal learning system method of training in the pharmaceutical industry. The findings suggest that: 1) managers in the pharmaceutical industry do prefer a training system under a specific learning method, 2) one subgroup of managers does not show preference for a nontraditional, individual and empirical learning system, 3) there is a difference between two subgroups of managers for a specific learning system, and 4) there is no significant statistical differences between gender preferences for a specific learning system.Keywords: human resources management, management, training, learning.
Gestión de los intangibles del capital humano. Política de retribuciones y sus efectos. El caso de los grupos de empresa cotizados españoles
Authors: Pérez Calderón Esteban , Milanés Montero Patricia , Gutiérrez Ponce Herenia
Published: April 2019

RESUMENEn los últimos años, las empresas han venido realizando grandes inversiones en generosos mecanismos de retribución y compensación a sus empleados con la esperanza de alcanzar un doble objetivo. Por un lado, que estas actuaciones sean reconocidas por el mercado de valores y, por otro, esperando un mayor retorno de la inversión realizada en su personal. En el presente trabajo comprobamos cómo están repercutiendo estas inversiones sobre la productividad de los empleados (resultados económicos) y si son premiadas por el mercado de capitales (resultados financieros). Nuestro estudio se centra en los grupos de empresa cotizados españoles.Palabras clave: gestión, intangibles, capital humano, política retributiva. Intangibles of human capital management. Remuneration policy and its effects. The case of the spanish groups listed companies.ABSTRACTIn recent years, companies have been investing heavily in generous remuneration and compensation models for its employees hope to achieve two objectives. On the one hand, that these actions are recognized by the stock market and, second, expecting a greater return on investment in their human capital. In this paper we focus on to see how these investments are having an impact on employee productivity (economic results) and if they are rewarded by the capital market (financial results). Our study focuses on Spanish groups listed companies.Keywords: management, intangibles, human capital, remuneration policy.
La contabilidad medioambiental y la gestión ambiental en las empresas ubicadas en la Región Suroeste Andina de Venezuela
Authors: Millán Vázquez de la Torr María Genoveva , Mora Pernía Betty Lucía
Published: April 2019

RESUMENLa gestión ambiental empresarial ha tomado, últimamente, mucha relevancia. Llevarla a cabo origina flujos de recursos económicos que afectan las operaciones de la empresa; por tanto se deben manejar herramientas que permitan incorporarlos a la contabilidad. Al efecto se han emitido normas, declaraciones y principios relacionados con los temas medioambientales para que puedan ser interpretados e incorporados a la información que se procesa en las empresas. Este artículo analiza los avances en estas cuestiones presentando un estudio empírico sobre la utilización de la contabilidad medioambiental.Palabras clave: contabilidad medioambiental, revelación de información medioambiental, gestión medioambiental empresarial. Environmental accounting and environmental management companies located in the Southwest Andino in VenezuelaABSTRACTThe Business environmental management has taken, ultimately, a lot of importance. Carry it out originates flows of economic resources that affect the operations of the business; therefore should be handled tools that permit to incorporate them to the accounting. To this effect have been issued standards, statements and principles related to the environmental themes so that they can be interpreted and incorporated to the information that is processed in the businesses. This paper analyzes the advances in these themes presenting an empirical study on the use of the environmental accounting.Keywords: environmental accounting, revelation of environmental information, business environmental management.