bluuebunny/crossref_metadata_2025 huggingface dataset:
TR35 Exerts Anti-tumor Effects by Modulating Mitogen-Activated Protein Kinase and STAT3 Signaling in Lung Cancer Cells
Authors: Shi Zhiyong , Gao Yang , Feng Lifeng , Tian Wencong , Dou Zhihua , Liu Chen , Liu Jie , Xu Yang , Wang Yachen , Yan Jie , Wu Qiang , Li Jing , Yang Liang , Zhang Zhaocai , Yang Jie , Qi Zhi
Published: October 2021

Cancer is a complex disease extremely dependent on its microenvironment and is highly regulated by a variety of stimuli inside and outside the cell. Evidence suggests that active camel whey fraction (TR35) confer anti-tumor effects in non-small cell lung cancer (NSCLC). However, its exact mechanisms remain elusive. Here, we investigated the mechanisms underlying suppression of NSCLC cell growth and proliferation by TR35. Treatment of A549 and H1299 cells with TR35 suppressed their growth and enhanced apoptosis, as revealed by CCK-8, colony formation and flow cytometric analyses. We find that TR35 suppresses tumor growth in a xenograft nude mouse model without losses in body weight. RNA-seq and KEGG pathway analyses showed that the DEGs were enriched in mitogen-activated protein kinase (MAPK) and Jak-STAT signaling pathways. After test the key factors’ activity associated with these pathways by Immunohistochemical (IHC) staining and western blotting, the activation of JNK phosphorylation and inhibition of p38 and STAT3 phosphorylation was observed both in TR35 treated lung cancer cell and tumor tissue. Taken together, these results showed that TR35 play a significant role in the NSCLC progression in the tumor microenvironment via MAPK and Jak-STAT signaling, highlighting TR35 as a potential therapeutic agent against lung cancer.
Design and Analysis of a Collaborative Story Generation Game for Social Robots
Authors: Nichols Eric , Gao Leo , Vasylkiv Yurii , Gomez Randy
Published: October 2021

Storytelling plays a central role in human socializing and entertainment, and research on conducting storytelling with robots is gaining interest. However, much of this research assumes that story content is curated. In this paper, we introduce the task ofcollaborative story generation, where an artificial intelligence agent, or a robot, and a person collaborate to create a unique story by taking turns adding to it. We present a collaborative story generation system which works with a human storyteller to create a story by generating new utterances based on the story so far. Our collaborative story generation system consists of a publicly-available large scale language model that was tuned on a dataset of writing prompts and short stories, and a ranker that samples from the language model and chooses the best possible output. We improve storytelling quality by optimizing the ranker’s sample size to strike a balance between quality and computational cost. Since latency can be detrimental to human-robot interaction, we examine the performance-latency trade-offs of our approach and find the optimal ranker sample size that strikes the best balance between quality and computational cost. We evaluate our system by having human participants play the collaborative story generation game and comparing the stories they create with our system to a naive baseline. Next, we conduct a detailed elicitation survey that sheds light on issues to consider when adapting our collaborative story generation system to a social robot. Finally, in a first step towards allowing human players to control the genre or mood of stories generated, we present preliminary work on steering story generation sentiment polarity with a sentiment analysis model. We find that our proposed method achieves a good balance of steering capability and text coherence. Our evaluation shows that participants have a positive view of collaborative story generation with a social robot and consider rich, emotive capabilities to be key to an enjoyable experience.
Invasion of the Asian Ladybird Harmonia axyridis (Pallas, 1773) in the European Part of Russia
Authors: Zakharov Ilia , Ruchin Alexandr , Egorov Leonid , Romanov Denis , Sazhnev Alexey
Published: October 2021

The natural range of the Asian ladybird Harmonia axyridis (Pallas, 1773) covers the territories of China, Mongolia, Korea, Japan, and Russia (Far East, Southern Siberia, and Altai). Since the early 1980's, the global invasion of H. axyridis began, first on the territory of the United States, from where the Asian ladybird spread to South America, Africa, and Europe. By 2016, this species occupied all of Western Europe with the exception of its northern and southern regions. Penetration of H. axyridis on the territory of the Russian Federation (Kaliningrad) was discovered in 2010, and since 2011, the species has spread to the Black Sea coast. This report presents our data on the distribution of Harmonia axyridis in central Russia, from its western borders, to the Volga River. The occupation of this huge territory by this species occurred mainly in the last 3 years−2018–2020. The rate of movement of the species on the territory of the European part of Russia is about 200 km/year.
Fast Posterior Estimation of Cardiac Electrophysiological Model Parameters via Bayesian Active Learning
Authors: Zaman Md Shakil , Dhamala Jwala , Bajracharya Pradeep , Sapp John L. , Horácek B. Milan , Wu Katherine C. , Trayanova Natalia A. , Wang Linwei
Published: October 2021

Probabilistic estimation of cardiac electrophysiological model parameters serves an important step toward model personalization and uncertain quantification. The expensive computation associated with these model simulations, however, makes direct Markov Chain Monte Carlo (MCMC) sampling of the posterior probability density function (pdf) of model parameters computationally intensive. Approximated posterior pdfs resulting from replacing the simulation model with a computationally efficient surrogate, on the other hand, have seen limited accuracy. In this study, we present a Bayesian active learning method to directly approximate the posterior pdf function of cardiac model parameters, in which we intelligently select training points to query the simulation model in order to learn the posterior pdf using a small number of samples. We integrate a generative model into Bayesian active learning to allow approximating posterior pdf of high-dimensional model parameters at the resolution of the cardiac mesh. We further introduce new acquisition functions to focus the selection of training points on better approximating the shape rather than the modes of the posterior pdf of interest. We evaluated the presented method in estimating tissue excitability in a 3D cardiac electrophysiological model in a range of synthetic and real-data experiments. We demonstrated its improved accuracy in approximating the posterior pdf compared to Bayesian active learning using regular acquisition functions, and substantially reduced computational cost in comparison to existing standard or accelerated MCMC sampling.
Direct and Indirect Effects of Environmental Limitations on White Spruce Xylem Anatomy at Treeline
Authors: Pampuch Timo , Anadon-Rosell Alba , Trouillier Mario , Lange Jelena , Wilmking Martin
Published: October 2021

Treeline ecosystems are of great scientific interest to study the effects of limiting environmental conditions on tree growth. However, tree growth is multidimensional, with complex interactions between height and radial growth. In this study, we aimed to disentangle effects of height and climate on xylem anatomy of white spruce [Picea glauca (Moench) Voss] at three treeline sites in Alaska; i.e., one warm and drought-limited, and two cold, temperature-limited. To analyze general growth differences between trees from different sites, we used data on annual ring width, diameter at breast height (DBH), and tree height. A representative subset of the samples was used to investigate xylem anatomical traits. We then used linear mixed-effects models to estimate the effects of height and climatic variables on our study traits. Our study showed that xylem anatomical traits in white spruce can be directly and indirectly controlled by environmental conditions: hydraulic-related traits seem to be mainly influenced by tree height, especially in the earlywood. Thus, they are indirectly driven by environmental conditions, through the environment’s effects on tree height. Traits related to mechanical support show a direct response to environmental conditions, mainly temperature, especially in the latewood. These results highlight the importance of assessing tree growth in a multidimensional way by considering both direct and indirect effects of environmental forcing to better understand the complexity of tree growth responses to the environment.
A Survey on One Health Approach in Colombia and Some Latin American Countries: From a Fragmented Health Organization to an Integrated Health Response to Global Challenges
Authors: Cediel Becerra Natalia Margarita , Olaya Medellin Ana María , Tomassone Laura , Chiesa Francesco , De Meneghi Daniele
Published: October 2021

The “One Health” (OH) approach has been recognized by world health authorities such as FAO/OIE/WHO, advocating for effective, multi-sectoral, and transdisciplinary collaboration. However, there is a lack of published evidence of the awareness of the OH concept in Colombia and other countries in the Latin American Region. In order to explore existing collaboration amongst the animal health, human-public health, environmental health sectors, and to describe the perception, knowledge, and barriers on OH in Colombia and other countries of Latin America, an online questionnaire-based survey was distributed among key professionals representing the three OH pillars (August 2018–August 2020). Overall, 76 key respondents from 13 countries (Colombia, México, Chile, Brazil, Argentina, Bolivia, Costa Rica, Ecuador, Perú, Guatemala, Nicaragua Uruguay, and Venezuela) completed the questionnaire. Respondents worked in institutions of animal (59%), public (20%), human (7%), and environmental health (7%); they mainly belonged to higher academic institutions (59%), followed by ministries (11%), and research organizations (9%). Most participants (92%) were familiar with the OH term and 68% were aware of the formal cooperation among sectors in their countries, mostly on zoonoses; in 46% of the cases, such connections were established in the last 5 years. The main reported limiting factors to intersectorality were the lack of commitment of policy-makers, resources, and budget for OH (38%) and the “siloed approach” of sectors and disciplines (34%). Respondents ranked a median score of 3.0 (1–5 scoring) in how good OH activities are implemented in their countries, and a median score of 2.0 in the citizen awareness on OH as regards their countries. The most important OH issues were identified in vector-borne diseases, rabies, wrong and/or improper use of antimicrobials, emerging viral diseases, food-borne diseases, neglected parasitic diseases, deforestation, and ecosystem fragmentation. Although there is a high-perceived importance on conjoint cooperation, OH implementation, and operationalization remain weak, and the environmental component is not well-integrated. We consider that integration and implementation of the OH Approach can support countries to improve their health policies and health governance as well as to advocate the social, economic, and environmental sustainability of the Region.
Behaviour Recognition with Kinodynamic Planning Over Continuous Domains
Authors: Fitzpatrick Grady , Lipovetzky Nir , Papasimeon Michael , Ramirez Miquel , Vered Mor
Published: October 2021

We investigate the application of state-of-the-art goal recognition techniques forbehaviourrecognition over complex continuous domains using model predictive control (MPC) for trajectory generation. We formally define the problem of kinodynamic behaviour recognition and establish a set of baseline behaviours and performance measures in the complex domain of unmanned aerial maneuvers. We evaluate how well our approach performs over a range of standard aerial maneuvers and representative initial configurations of varying complexity. The work also highlights future research directions in compound model-based behaviour recognition and team behaviour recognition where multiple agents may be acting simultaneously.
Together We can Figure It out: Groups Find Hospitality Robots Easier to Use and Interact With Them More than Individuals
Authors: Preusse Harrison , Skulsky Rebecca , Fraune Marlena R. , Stringam Betsy Bender
Published: October 2021

As robots are becoming more prevalent and entering hospitality settings, understanding how different configurations of individuals and groups interact with them becomes increasingly important for catering to various people. This is especially important because group dynamics can affect people’s perceptions of situations and behavior in them. We present research examining how individuals and groups interact with and accept a humanoid robot greeter at a real-world café (Study 1) and in an online study (Study 2). In each study, we separately examine interactions of individuals, groups that participants formed after they arrived at the café (new-formed groups), and groups that participants arrived with at the café (pre-formed groups). Results support prior findings that groups are more likely to interact with a public robot than individuals (Study 1). We also report novel findings that new-formed groups interacted more with the robot than pre-formed groups (Study 1). We link this with groups perceiving the robot as more positive and easier to use (Study 2). Future research should examine perceptions of the robot immediately after interaction and in different hospitality contexts.
How Are Microplastics Invading the World?
Authors: Lujan-Vega Charlene , Ortega-Alfaro José Luis , Cossaboon Jennifer , Acuña Shawn , Teh Swee J.
Published: October 2021

Microplastics are tiny plastic pieces, <5 mm, which is smaller than a pencil eraser. Did you know that you can find microplastics everywhere? They are in the air, water, soil, and within living creatures. You can find them from the deep sea to the snow in the Arctic. You can find them across beaches in California, and in the San Francisco Bay waters. Many living organisms ranging from zooplankton to whales contain microplastics in their bodies, including aquatic creatures from California. In this article, you will learn about the origin of microplastics, where you can find them, why they are a concern, how they can affect the Sacramento-San Joaquin Delta, and how you can help to reduce their global invasion.
Survival Benefit of Surgical Treatment Added Into Systemic Treatment for Isolated Breast Cancer Liver Metastases: A Systematic Review and Meta-Analysis
Authors: Sun Ming-Shuai , Liu Hong-Jin , Yun Yong-Yang , Yu Zheng-Heng , Yang Fan , Liu Yin-Hua , Xu Ling
Published: October 2021

Background: Compared with systemic treatment alone, whether surgical treatment combined with systemic treatment can improve survival outcomes of patients with isolated breast cancer liver metastases (BCLM) is still controversial. This meta-analysis was designed to evaluate the efficacy of surgical treatment for patients with isolated BCLM.

Methods: A systematic search of PubMed, Embase, and Cochrane Library up to May 13, 2021 was conducted for relevant studies. The primary outcome was overall survival. The meta-analysis was performed using R software. The quality of the pooled study was assessed using the Newcastle-Ottawa scale. The publication bias was evaluated by funnel plots and Begg's and Egger's tests. Fixed- and random-effects models were applied according to heterogeneity.

Results: 9 retrospective studies involving 13 cohorts (7 unmatched cohorts and 6 matched cohorts) were included in this study. The surgical cohorts had better overall survival than the systemic cohorts in the pooled analysis of all the included studies, in the subgroup analysis of liver resection, and in the subset of the matched cohorts.

Conclusions: Compared with systemic treatment alone, surgical treatment combined with systemic treatment was proven to be associated with superior survival outcomes, which should be considered in selected patients with isolated BCLM.
Case Report: Persistent Moderate-to-Severe Creatine Kinase Enzyme Activity Elevation in a Subclinical Dog
Authors: Gunther Melissa , Jaffey Jared A. , Evans Jason , Paige Christopher
Published: October 2021

A 4-year-old, male-castrated, mixed breed dog was presented for a routine wellness examination at which time a moderate increase in serum creatine kinase (CK) enzyme activity (hyperCKemia) (15,137 IU/L; reference interval 10–200 IU/L), and moderate increases in alanine transaminase and aspartate aminotransferase enzyme activities were first identified. There was no history of clinical abnormalities (e.g., lethargy, lameness, anorexia, dysphagia, weakness, gait abnormalities, or exercise intolerance) and the physical examination was unremarkable. The dog was screened for several relevant potential infectious diseases known to cause inflammatory myopathies and was treated empirically with clindamycin. The serum total CK enzyme activity remained increased, which prompted recommendations for an echocardiogram, electromyogram (EMG), and muscle biopsy acquisition. The echocardiogram and electrocardiographic monitoring were unremarkable. The EMG and muscle biopsies were declined by the owner. The dog was evaluated several times in the subsequent 5 years and remained subclinical with unremarkable physical examinations despite a persistent moderate-to-severe hyperCKemia. Differential diagnoses considered most likely in this dog were an occult/latent hereditary muscular dystrophic disorder or idiopathic hyperCKemia, a phenomenon not yet reported in the veterinary literature. This report describes for the first time, clinical and diagnostic features of a subclinical dog with persistent moderate-to-severe hyperCKemia.
Spring Water Geochemistry: A Geothermal Exploration Tool in the Rhenohercynian Fold-and-Thrust Belt in Belgium
Authors: Cabidoche Marina , Vanbrabant Yves , Brouyère Serge , Stenmans Vinciane , Meyvis Bruno , Goovaerts Thomas , Petitclerc Estelle , Burlet Christian
Published: October 2021

Spring water geochemistry is applied here to evaluate the geothermal potential in Rhenohercynian fold and thrust belt around the deepest borehole in Belgium (Havelange borehole: 5648 m MD). Fifty springs and (few) wells around Havelange borehole were chosen according to a multicriteria approach including the hydrothermal source of “Chaudfontaine” (T ≈ 36 °C) taken as a reference for the area. The waters sampled, except Chaudfontaine present an in-situ T range of 3.66–14.04 °C (mean 9.83 °C) and a TDS (dry residue) salinity range of 46–498 mg/L. The processing methods applied to the results are: hierarchical clustering, Piper and Stiff diagrams, TIS, heat map, boxplots, and geothermometry. Seven clusters are found and allow us to define three main water types. The first type, locally called “pouhon”, is rich in Fe and Mn. The second type contains an interesting concentration of the geothermal indicators: Li, Sr, Rb. Chaudfontaine and Moressée (≈5 km East from the borehole) belong to this group. This last locality is identified as a geothermal target for further investigations. The third group represents superficial waters with frequently high NO3 concentration. The application of conventional geothermometers in this context indicates very different reservoir temperatures. The field of applications of these geothermometers need to be review in these geological conditions.
Carbonic Anhydrase Inhibitors and Epilepsy: State of the Art and Future Perspectives
Authors: Ciccone Lidia , Cerri Chiara , Nencetti Susanna , Orlandini Elisabetta
Published: October 2021

Carbonic anhydrases (CAs) are a group of ubiquitously expressed metalloenzymes that catalyze the reversible hydration/dehydration of CO2/HCO3. Thus, they are involved in those physiological and pathological processes in which cellular pH buffering plays a relevant role. The inhibition of CAs has pharmacologic applications for several diseases. In addition to the well-known employment of CA inhibitors (CAIs) as diuretics and antiglaucoma drugs, it has recently been demonstrated that CAIs could be considered as valid therapeutic agents against obesity, cancer, kidney dysfunction, migraine, Alzheimer’s disease and epilepsy. Epilepsy is a chronic brain disorder that dramatically affects people of all ages. It is characterized by spontaneous recurrent seizures that are related to a rapid change in ionic composition, including an increase in intracellular potassium concentration and pH shifts. It has been reported that CAs II, VII and XIV are implicated in epilepsy. In this context, selective CAIs towards the mentioned isoforms (CAs II, VII and XIV) have been proposed and actually exploited as anticonvulsants agents in the treatment of epilepsy. Here, we describe the research achievements published on CAIs, focusing on those clinically used as anticonvulsants. In particular, we examine the new CAIs currently under development that might represent novel therapeutic options for the treatment of epilepsy.
Pan-ROCK and ROCK2 Inhibitors Affect Dexamethasone-Treated 2D- and 3D-Cultured Human Trabecular Meshwork (HTM) Cells in Opposite Manners
Authors: Watanabe Megumi , Ida Yosuke , Furuhashi Masato , Tsugeno Yuri , Hikage Fumihito , Ohguro Hiroshi
Published: October 2021

Effects of a pan-ROCK-inhibitor, ripasudil (Rip), and a ROCK2 inhibitor, KD025 on dexamethasone (DEX)-treated human trabecular meshwork (HTM) cells as a model of steroid-induced glaucoma were investigated. In the presence of Rip or KD025, DEX-treated HTM cells were subjected to permeability analysis of 2D monolayer by transendothelial electrical resistance (TEER) and FITC–dextran permeability, physical properties, size and stiffness analysis (3D), and qPCR of extracellular matrix (ECM), and their modulators. DEX resulted in a significant increase in the permeability, as well as a large and stiff 3D spheroid, and those effects were inhibited by Rip. In contrast, KD025 exerted opposite effects on the physical properties (down-sizing and softening). Furthermore, DEX induced several changes of gene expressions of ECM and their modulators were also modulated differently by Rip and KD025. The present findings indicate that Rip and KD025 induced opposite effects toward 2D and 3D cell cultures of DEX-treated HTM cells.
Thermal Analysis of Binary Mixtures of Imidazolium, Pyridinium, Pyrrolidinium, and Piperidinium Ionic Liquids
Authors: Gómez Elena , Velho Pedro , Domínguez Ángeles , Macedo Eugénia A.
Published: October 2021

Ionic liquids (ILs) are being widely studied due to their unique properties, which make them potential candidates for conventional solvents. To study whether binary mixtures of pure ionic liquids provide a viable alternative to pure ionic liquids for different applications, in this work, the thermal analysis and molar heat capacities of five equimolar binary mixtures of ionic liquids based on imidazolium, pyridinium, pyrrolidinium, and piperidinium cations with dicyanamide, trifluoromethanesulfonate, and bis(trifluoromethylsulfonyl)imide anions have been performed. Furthermore, two pure ionic liquids based on piperidinium cation have been thermally characterized and the heat capacity of one of them has been measured. The determination and evaluation of both the transition temperatures and the molar heat capacities was carried out using differential scanning calorimetry (DSC). It was observed that the thermal behavior of the mixtures was completely different than the thermal behavior of the pure ionic liquids present, while the molar heat capacities of the binary mixtures were very similar to the value of the average of molar heat capacities of the two pure ionic liquids.
Analysis of Static Molecular Gradients in a High-Throughput Drug Screening Microfluidic Assay
Authors: Szafran Roman G. , Wiatrak Benita
Published: October 2021

In this study, we thoroughly analyzed molecular gradient generation, its stability over time, and linearity in our high-throughput drug screening microfluidic assay (HTS). These parameters greatly affect the precision and accuracy of the device’s analytical protocol. As part of the research, we developed a mathematical model of dependence of the concentration profile on the initial concentrations of active substances in reservoirs and the number of tilts, as well as the dependence of the active substance concentration profiles in the culture chambers on the concentration profile of the reference dye in the indicator chamber. The mean concentration prediction error of the proposed equations ranged from 1.4% to 2.4% for the optimized parameters of the procedure and did not increase with the incubation time. The concentration profile linearity index, Pearson’s correlation coefficient reached −0.997 for 25 device tilts. The observed time stability of the profiles was very good. The mean difference between the concentration profile after 5 days of incubation and the baseline profile was only 7.0%. The newly created mathematical relationships became part of the new HTS biochip operating protocols, which are detailed in the article.
Microencapsulated and Lyophilized Propolis Co-Product Extract as Antioxidant Synthetic Replacer on Traditional Brazilian Starch Biscuit
Authors: Rodrigues Rodrigo , Bilibio Denise , Plata-Oviedo Manuel S. V. , Pereira Edimir A. , Mitterer-Daltoé Marina L. , Perin Ellen C. , Carpes Solange T.
Published: October 2021

The residue from commercial propolis extraction may have significant antioxidant power in food technology. However, among the challenges for using the propolis co-product as an inhibitor of lipid oxidation (LO) in baked goods is maintaining its bioactive compounds. Therefore, this study aimed to determine the propolis co-product extracts’ capability to reduce LO in starch biscuit formulated with canola oil and stored for 45 days at 25 °C. Two co-product extracts were prepared: microencapsulated propolis co-product (MECP) (with maltodextrin) and lyophilized propolis co-product (LFCP), which were subjected to analysis of their total phenolic content and antioxidant activity (AA). Relevant antioxidant activity was observed using the methods of analysis employed. The spray-drying microencapsulation process showed an efficiency of 63%. The LO in the biscuits was determined by the thiobarbituric acid reactive substances (TBARS) test and fatty acid composition by gas chromatography analysis. Palmitic, stearic, oleic, linoelaidic, linoleic, and α-linolenic acids were found in biscuits at constant concentrations throughout the storage period. In addition, there was a reduction in malondialdehyde values with the addition of both propolis co-product extracts. Therefore, the propolis co-product extracts could be utilized as a natural antioxidant to reduce lipid oxidation in fatty starch biscuit.
FTIR Spectroscopy as a Tool to Study Age-Related Changes in Cardiac and Skeletal Muscle of Female C57BL/6J Mice
Authors: Magalhães Sandra , Almeida Idália , Martins Filipa , Camões Fátima , Soares Ana R. , Goodfellow Brian J. , Rebelo Sandra , Nunes Alexandra
Published: October 2021

Studying aging is important to further understand the molecular mechanisms underlying this physiological process and, ideally, to identify a panel of aging biomarkers. Animals, in particular mice, are often used in aging studies, since they mimic important features of human aging, age quickly, and are easy to manipulate. The present work describes the use of Fourier Transform Infrared (FTIR) spectroscopy to identify an age-related spectroscopic profile of the cardiac and skeletal muscle tissues of C57BL/6J female mice. We acquired ATR-FTIR spectra of cardiac and skeletal muscle at four different ages: 6; 12; 17 and 24 months (10 samples at each age) and analyzed the data using multivariate statistical tools (PCA and PLS) and peak intensity analyses. The results suggest deep changes in protein secondary structure in 24-month-old mice compared to both tissues in 6-month-old mice. Oligomeric structures decreased with age in both tissues, while intermolecular β-sheet structures increased with aging in cardiac muscle but not in skeletal muscle. Despite FTIR spectroscopy being unable to identify the proteins responsible for these conformational changes, this study gives insights into the potential of FTIR to monitor the aging process and identify an age-specific spectroscopic signature.
A Facile Approach to Bis(isoxazoles), Promising Ligands of the AMPA Receptor
Authors: Vasilenko Dmitry A. , Sadovnikov Kirill S. , Sedenkova Kseniya N. , Karlov Dmitry S. , Radchenko Eugene V. , Grishin Yuri K. , Rybakov Victor B. , Kuznetsova Tamara S. , Zamoyski Vladimir L. , Grigoriev Vladimir V. , Palyulin Vladimir A. , Averina Elena B.
Published: October 2021

A convenient synthetic approach to novel functionalized bis(isoxazoles), the promising bivalent ligands of the AMPA receptor, was elaborated. It was based on the heterocyclization reactions of readily available electrophilic alkenes with the tetranitromethane-triethylamine complex. The structural diversity of the synthesized compounds was demonstrated. In the electrophysiological experiments using the patch clamp technique on Purkinje neurons, the compound 1,4-phenylenedi(methylene)bis(5-aminoisoxazole-3-carboxylate) was shown to be highly potent positive modulator of the AMPA receptor, potentiating kainate-induced currents up to 70% at 10−11 M.
Influence of Supercritical Carbon Dioxide Extraction Conditions on Extraction Yield and Composition of Nigella sativa L. Seed Oil—Modelling, Optimization and Extraction Kinetics regarding Fatty Acid and Thymoquinone Content
Authors: Gawron Grzegorz , Krzyczkowski Wojciech , Łyżeń Robert , Kadziński Leszek , Banecki Bogdan
Published: October 2021

Nigella sativa L. is cultivated in many regions and its seeds have found use in variety of foods, but also in traditional medicine due to high content of biologically active essential oils. In this work optimization of supercritical carbon dioxide extraction from N. sativa seeds was performed using response surface methodology to describe the influence of extraction conditions on oil yield. Kinetics of oil and thymoquinone extraction were analyzed as well. It was demonstrated that in order to collect thymoquinone-rich N. sativa oil fraction, appropriate for health-related applications, the extraction should be carried out at 40 °C and 10–15 MPa. Following application of higher pressure of 35 MPa enables effective extraction of remaining oil rich in polyunsaturated fatty acids suitable for use in food industry. Thymoquinone-dependent antibacterial activity of the N. sativa seed oil was observed against bacterial pathogens: Haemophilus influenzae, Staphylococcus haemolyticus, Staphylococcus epidermidis, Enterococcus faecalis and Escherichia coli.
О некоторых вопросах зарождения и деятельности политических партии Казахстана конца ХIХ и нач. XX-го века: On some issues of origin and activity political parties of Kazakhstan at the end of 19th and beginning 20th century
Authors: NURPEISSOVA Bakyt
Published: October 2021

The article highlights the history of the origin and activities of various political parties in Kazakhstan that came to the political arena in the late 19th and early 20th centuries. On the basis of archival documents and other sources, the program provisions, goals and objectives of their activities have been studied. The article describes and analyzes the composition of the participants in political parties and movement. The forms, methods of struggle are described, the reasons and conditions for the emergence of political parties and movements that existed at that time are analyzed. Also important in the political life of Kazakhstan at the beginning of the twentieth century, the history of the origin and activities of the national party ‘Alash’. The article devotes a special place to political exiles who deserve an assessment of their tireless activity, who, despite the strict and secret surveillance of the gendarmerie, continued the struggle against the tsarist autocracy. The political exiles of the beginning of the 20th century, who found themselves in a foreign land in captivity and cut off from their own living environment, already in the new conditions are organized into political unions and continue to fight
„Wygooglować” biografię – subiektywny przewodnik dla biografów pasjonatów: ‘to google’ biography - a subjective guide for passionate biographers
Authors: KOZARSKA Ewa , SMYK Anita
Published: October 2021

The article is a guide for 'amateur historians' whose research on regional history has been limited by restrictions on population mobility caused by COVID-19. It provides practical tips on how to use Open Access e-resources to compile biographies.
Studi Komunitas Makrozoobenthos di Perairan Kuala Gigeng, Kabupaten Aceh Besar
Authors: Razi Nanda Muhammad , Agustiar Muhammad , Fazillah Muhammad Rizki , Sakinah Rauzatul , Octavina Chitra
Published: October 2021

Tujuan penelitian ini adalah untuk mengetahui struktur komunitas makrozoobenthos di Perairan Kuala Gigeng dari tahun 2017 sampai 2019.Metode yang digunakan pada penelitian ini adalah metode purposive sampling. Hasil penelitian menunjukkan bahwa terdapat 2 kelas makrozoobenthos yaitu kelas Crustacea yang terdiri dari spesiesGrapsus albolineatus, Strombidae, Cancelaridae, dan kelas Gastropoda terdiri dari spesiesMarginella nebulosa, dan Marginella sp.. Secara keseluruhan kepadatan makrozoobenthos berkisar antara 0,06-0,12 ind/m2. Indeks keanekaragaman makrozoobenthos tergolong kedalam kategori rendah, keseragaman tergolong rendah dan dominansi tergolong ke dalam ketagori tinggi.Kata kunci:  Bioindikator, Kuala Gigeng, Makrozoobenthos, Struktur Komunitas
OPINI MASYARAKAT MENGENAI HATE SPEECH PADA MEDIA MASSA TERHADAP ULAMA (Studi Kasus pada Masyarakat Meulaboh, Aceh Barat)
Authors: Marisa Siti Nurkhafifah , Juliana Rena , Juliani Reni
Published: October 2021

At present, there is much news of hate speech against ulama circulating in the mass media. Hate speech can have a negative impact on human relationships and between the religious communities developed to date. The purpose of this research is to discuss how the public opinion of Meulaboh presents to the mass media messages containing hate speech directed against ulama. This research used a qualitative approach by collecting data through interviews with 4 people from Meulaboh City and 2 lecturers of KPI STAIN Meulaboh. The results of this study show that having a huge impact on the news in the media for the community, especially the presence of gadgets, allows people to easily access a lot of the latest news. People who still hold strong religious values think the news is inappropriate. The news presented by the media is expected to be neutral and impartial, which can harm other parties.
Kajian Teknis Pengelolaan Air Asam Tambang, PT Sarolangun Bara Prima, Kabupaten Sarolangun, Provinsi Jambi
Authors: Desiana Niza
Published: October 2021

Air asam tambang terbentuk karena adanya mineral FeS (pyrite) yang teroksidasi, air asam ini berasal dari tambang atau batuan yang mengandung mineral sulfida tertentu yang terpapar dan dalam keadaan teroksidasi. Adapun sumber dari air asam tambang pada PT Sarolangun Bara Prima ini berasal dari sistem penambangan terbuka yang digunakan, khususnya pada pit penambangan yang terdapat genangan air yang berasal dari air tanah bekas lubang bor. Adapun PH rata-rata air asam tambang sebelum dilakukan treatment adalah 5 dan apabila diberi treatment pH rata-ratanya adalah 6.5. Dalam pengelolaan air asam tambang di PT Sarolangun Bara Prima ini diawali dengan pemindahan air asam tambang menuju sump selanjutnya dialirkan settling pond, untuk treatment  menetralkan pH air tidak rutin dilaksanakan, air asam ini sering dialirkan langsung kesungai tanpa diberikan treatment khusus, oleh sebab itu diperlukan pengelolaan air asam tambang secara rutin dan lebih efektif agar mencegah timbulnya pencemaran lingkungan.
Significance of a software interoperability matrix for architectural engineering and construction industry
Authors: Kalutara Pushpitha , London Kerry , Taylor Claudelle
Published: October 2021

Traditional project management applications are appeared working separately of their participating project teams and isolating the input of each team to both geometry and non-geometry of the project. With the introduction of Building Information Modelling (BIM), Architectural, Engineering and Construction (AEC) industry expected it would be a panacea as a tool to effectively collaborate project teams and to efficiently share geometry and non-geometry data relevant to not only design and construction but also covering the whole life-cycle of the project. All these BIM functions are relied on its automation capability; in other words, BIM vision totally discourages manual processing of data. As a result, good interoperability practice needs to pass data automatically between applications of different project teams. Many international associations are working in search of full interoperability among BIM players of the project; however, the goal is yet to succeed. The current study identifies the impact due to poor interoperability between applications and takes considerable effort to minimise or eliminate if possible. Software Interoperability Matrix (SIM) is the proposed solution delivering the outcome. Action research is the methodology adopted to develop SIM, in which researchers and professionals actively participated. Major industry contribution of SIM is to realise interoperability issues between BIM players prior to the project and upon identification, precautionary measures can be taken introducing new plug-ins or completely switching to new compatible application if it is the only solution.
Decentralizing art making: Commentaries on curating online artist residency “Flaneur in the Insular Cities”
Authors: Kin Man Cheong , Lee Yipei
Published: October 2021

One of the main natural obstacles of Western-privileged globalization of cultures is the world’s systems of productivity in most fields that tend to follow, if not obey, the Western-origin categorizing forces. The many world networks of parallel yet intertwined ways of thinking and of producing knowledge - and in this case, making art - in its most diverse sense preserves a striking diversity. In this sense, when categorization becomes loosened, the boundary becomes blurred and rationality becomes flexibilized in a particular cultural background and a specific curating act. The fluidity of meanings in a Westernen-like perspective within the essence of organizational forces and lines thus offers a poetics that in turn (re-)defines art making, both art and making, in its very own right. Advocating for knowledge production decentralization, Yipei Lee, the co-curator of internet artist residency “Flaneur in the insular cities: island ecology” (漫遊島城——島嶼生態學), is very much the case of this poetics. Putting it in a less utopian wording, Lee’s co-curation offers a chance to funding entities, research-based artists and curators themselves to build a multifying dimension of co-centralities in art making. This poetics of playing with meanings in art making itself is marked by the project’s all-encompassing interrelations and interactions among curators and artists rhizome-like webs of ideas that have been materialized during the ongoing process of this online residency: Participating individuals are supposed to do flânerie as their own initiatives within and without some certain universality of insularity and its ecologicality as main themes of their artistic research. This essay aims at exploring, if not attempts to offer an insight on how the elasticity and flexibleness of to-be-reappropriated meanings in this particular case can serve as an alternative way of decentralization, while giving a very brief overview about the event.While Lee as an independent curator offers necessary empirical evidence for the writing of this essay, Cheong Kin Man, as a visual anthropologist, tries to give third-party commentaries and observations on it.
The limitless Possibility of Combination: Filmic Lego Poetics of Storytelling and Structure in Global Film Scriptwriting and Duration
Authors: Lok Sobel Chan Ka
Published: October 2021

Feature film is most limited in 90 mins in Chinese-language films to 120 mins in Hollywood films in term of length and duration, and there are popularly summarizing in several film structures like 3 act , 4 act, 5 act structure, John Truby’s story anatomy, Blake Synder’s Beat Sheet, Christopher Vogler’s Hero Journey, Paul’s Sequence Approach, etc. the well-established film structure is well tested and practiced in film industry in term of box office, film comments and general audience’ likeness and taste. It is so popular as it does suit the tastes and viewing habit of general audience. However, it will also limit the unlimited possibility of film structure and storytelling in another angle and how we perceive the film story concept. Therefore, this original and innovative paper would explore the interactive relationship and poetics between the length, duration and film storytelling and structure in a metaphysical and aesthetical form. If we can challenge or revisit the traditional film structure form, it may enlighten and explore the possibility of film art and our perception of film story. it may not just be about “problem and resolution” pattern. Everything can be possible like the bricks in Lego as film art is still very young in art historical aspect. Therefore, the paper challenges our traditional sense of frame to frame becoming shot, shot to shot becoming scene, scene to scene becoming sequence, sequence to sequence becoming act, and finally, act to act becoming film concept. It also challenges our long established understanding of how we view the film in 90 to 120 mins duration.  In the end, the paper would propose a new paradigm or model of film structure.
Kesenjangan Digital di Kalangan Guru SD dengan Rentang Usia 20-58 Tahun di Kecamatan Rajabasa
Authors: Zulfa Hazizah  , Henry Aditia Rigianti
Published: October 2021

Teknologi Informasi dan komunikasi berkembang pesat di masyarakat. Tidak semua kalangan mampu beradapsi dengan perkembangan teknologi. Hal ini menjadi faktor dari kesenjangan digital, sehingga muncul istilah baru yakni gagal teknologi (gaptek). Kesejangan digital merupakan ketidak mampuan individu dalam merasakan manfaat dari teknologi informasi karena kurangnya akses dan kemampuan dalam penggunaan TIK. Kesenjangan digital karena belum tersedianya dana dan sumber daya yang mendukung lembaga pendidikan serta sarana dan prasarana yang terkait dengan infrastruktur komunikasi berbasis TIK yang terbatas, dan yang menjadi kendala yakni belum siapnya budaya dan kultur penggunaan dan pemanfatan TIK. Penelitian ini untuk melihat kesenjangan digital yang terjadi di kalangan guru di Kabupaten Lampung Selatan Kecamatan Rajabasa. Penelitian ini di kaji berdasarkan dari teori dan pendapat ahli, mengenai kesenjangan digital pada guru senior dan guru junior yang begitu signifikan dalam pengoprasian perangakat TIK.Kata kunci: Kesenjangan Digital., Hadwere, Shoftwer, Useware
Hungarian geographical names of Mongolian origin
Authors: Пачаи Имре
Published: October 2021

в статье рассматриваются венгерские топонимы, отражающие монгольские контакты. Это подтверждается выводами известного венгерского ученого Gyula László. Проф. Ласло в своей работе указывает на необходимость более углубленного изучения монгольско-венгерских контактов, которые подтверждаются данными археологии. При сопоставительном изучении венгерских топонимов обнаружились фонетические и семантические мотивы, указывающие на их монгольское происхождение.

the article deals with Hungarian toponyms reflecting Mongolian contacts. This is confirmed by the conclusions of the famous Hungarian scientist Gyula László. In his work, Professor G. Laszlo points out the need for a more in-depth study of Mongolian-Hungarian contacts, which are confirmed by archaeological data. A comparative study of Hungarian toponyms revealed phonetic and semantic motifs indicating their Mongolian origin.
Formation of students' creative activity skills: problems and features
Authors: Пржиленская И.Б.
Published: October 2021

креативный потенциал специалиста, является уникальным сочетанием личностных качеств и профессиональных навыков. Он позволяет создавать новый продукт в ходе профессиональной деятельности. Креативность как ключевая компетенция будущего специалиста тесно связана со стратегиями адаптации личности к реалиям современного рынка труда. Цель исследования заключается в выявлении среди методов и форм работы с обучающимися развивающих креативных компетенций, которые позволяют решать профессиональные и жизненные задачи в условиях нестандартных и неожиданных ситуаций. Анализ практики профессиональной подготовки в современных вузах показывает отсутствие системности при формировании у обучающихся навыков креативной деятельности. Преодоление проблемы связано с созданием специальной коммуникативной среды, на основе диалогических и практикоориентированных форм обучения.

the creative potential of a specialist is a unique combination of personal qualities and professional skills. It allows you to create a new product during professional activity. Creativity as a key competence of a future specialist, a strategy with strategies for adapting a person to the realities of the modern labor market. The purpose of the study is to identify methods and forms of work with educational developing creative competencies that allow solving professional and life tasks in non-standard and unexpected situations. An analysis of the practice of professional training in the conditions of modern universities shows the lack of consistency in the formation of students' skills of creative activity. Overcoming the problem is associated with the creation of a special communicative environment, based on dialogical and practice-oriented forms of learning.
Alt Ekstremite Periferik Arter Hastalığında Mobil Sağlık Uygulamalarının Kullanımı
Authors: ŞAHAN Dilara , GEZER Nurdan , AKYÜZ Yakup
Published: October 2021

Periferik arter hastalığı (PAH); ekstremite arterlerinde ateroskleroza bağlı olarak gelişen kronik seyirli ve ilerleyici bir dolaşım bozukluğudur. Hastalık, cerrahi girişime kadar ilaç tedavisi ve yaşam tarzı değişiklikleri ile yönetilirken, sürecin uzaması ile hastaların yaşamı olumsuz etkilenebilmektedir. PAH giderek artan sıklığı, tedavisinin uzun, yüksek maliyetli olması, izlem ve tedavisinin yetersiz ve kontrolsüz kaldığı durumlarda ortaya çıkardığı akut ve kronik komplikasyonlar sonucu bireyin iyilik haline zarar vermekte, fonksiyonel kapasitesini etkilemekte ve sosyal ve mesleki rollerini yerine getirme yeteneğini engellemesi nedeniyle önemli bir sağlık sorunu olarak karşımıza çıkmaktadır. PAH’lı bireylerde iyi bir izlem ve hastalık yönetiminin sağlanması ile komplikasyonların oluşması ya da hastalığın ilerlemesinin engellenmesi mümkün olabilmektedir. Teknolojinin gelişimi bütün alanlarda olduğu gibi sağlık alanında da vazgeçilmez bir unsur haline gelmektedir. PAH’ın etkin bir şekilde izlenmesi ve yönetimi için günümüz gelişen teknolojisi önemli çözümler sunmakta olup bunlardan birini mobil sağlık uygulamalarının kullanımı oluşturmaktadır. Yapılan çalışmalara göre PAH’ın izlenmesi ve yönetiminde mobil sağlık uygulamalarının olumlu ve olumsuz etkileri olmuştur. Ülkemizde PAH tanısı alan bireylerde mobil sağlık uygulamalarının kullanılarak yapıldığı herhangi bir yayına rastlanmamıştır. Bu derleme, PAH tanısı alan bireylerin hastalıklarının yönetimi ve izlenmesinde mobil sağlık uygulamalarının kullanılmasının önemini vurgulamak ve ülkemizde konu ile ilgili ileriye dönük olarak yapılabilecek çalışmalar için temel bilgilendirme sağlamak amacıyla oluşturulmuştur.