bluuebunny/crossref_metadata_2025 huggingface dataset:
The Influence of Intellectual Capital and Corporate Social Responsibility on Financial Performance and Company Value
Authors: Sholikhah Alfiyatus , Hermawan Sigit
Published: December 2022

The purpose of this study was to examine the effect of Intellectual Capital and Corporate Social Responsibility on Financial Performance and Firm Value (Study on Banking and Insurance Companies Listed on the Indonesia Stock Exchange in 2016-2019). The variables studied in this study were Intellectual Capital, Corporate Social Responsibility, Financial Performance, and Company Value. The type of research used in this research is quantitative. This study uses secondary data from the financial statements of banking and insurance companies (annual reports) listed on the Indonesia Stock Exchange in 2016-2019. The analytical method used is using multiple linear regression analysis with the help of the SPSS 26 program. The results of this study indicate that (1) Intellectual Capital has no effect on Financial Performance (2) Intellectual Capital has no effect on Firm Value (3) Corporate Social Responsibility has no effect on Financial Performance (4) Corporate Social Responsibility has no effect on Firm Value.
The Effect of Financial Literacy, Financial Inclusion, Fintech Crowdfunding on MSME Performance in Sidoarjo Regency
Authors: Dewi Ajeng Listyo , Setiyono Wisnu Panggah
Published: December 2022

In 2020, Indonesia and even the world experienced a COVID-19 pandemic. As a result, many aspects of life were affected by the COVID-19 pandemic, including the economic aspect. One of the efforts to rebuild the economic aspect is to encourage the performance of MSMEs in a country. MSMEs are an important engine to encourage a country's economic growth. This study aims to develop previous research on the effect of financial literacy, financial inclusion, and fintech crowdfunding on MSME performance in the Sidoarjo Regency. This study used cluster random sampling as a sampling technique. A total of 177 MSME owner-manager questionnaire data were processed using multiple linear regression analysis. The results of the study prove that there is a positive and significant influence between financial literacy on the performance of MSMEs, financial inclusion has a positive and significant effect on the performance of MSMEs, and fintech crowdfunding has a negative and insignificant effect on the performance of MSMEs. This study shows that MSME business owners need to be technology and financial literate because it can enable them to make good financial decisions to ensure the sustainability of their business.
The Impact of Firm Size, Capital Structure and Dividend Policy on Firm Value during Covid-19 Pandemic
Authors: Purnamasari Dian Indri , Fauziah Muthia Riza
Published: December 2022

The present study aims to obtain empirical evidence for the impact of firm size, capital structure and dividend policy on the firm value of hotel, restaurant, and tourism companies listed on the Indonesia Stock Exchange (IDX) for the years 2019-2020.  The data used in this research are secondary data obtained from companies’ annual reports. The study population comprised of hotel, restaurant, and tourism companies listed on IDX for the years 2019-2020. The sample consists of 24 hotel, restaurant, and tourism companies listed on IDX for the years 2019-2020 and selected using a purposive sampling technique. The study used a multiple linear regression analysis. The results suggested that firm size, capital structure, and dividend policy have no impact on the firm value of hotel, restaurant, and tourism companies listed on IDX for the years 2019-2020.
Determinants of Discipline of Micro, Small and Medium Enterprises Tax Bearers
Authors: Sabaruddin Sabaruddin
Published: December 2022

This study aims to analyze how much influence awareness, understanding, tax sanctions, and income levels have on the discipline of small, micro, and medium enterprises (MSME) to bearers. The theory that underlies this research is the theory of planned behavior (TPB) which is related to the discipline of the tax bearer. Behavioral theory explains behavior change caused by several things. The population used in this study is MSME taxpayers registered with PD Pasar Jaya Jakarta, with a sample of 234 MSMEs. The analytical method used is multiple linear regression. The result of the independent test on the variable that taxpayer awareness has a negative and insignificant effect on the discipline of MSME tax bearers. However, the understanding of taxation has a positive and significant effect on MSME discipline. Likewise, tax sanction and the income level of the tax bearer has a positive and significant effect on MSME tax discipline. Meanwhile simultaneously testing the effect of awareness, understanding of taxation, tax sanctions, and income level a significant effect on MSME tax discipline. The implication of this research is that the discipline of the tax bearer can increase with high awareness and understanding of tax provisions.
«Ir contra el viento», una refundición de José Fernández Guerra de «Yo por vos y vos por otro» de Agustín Moreto
Authors: Santana Bustamante Carmen
Published: December 2022

En este artículo se presenta un estudio comparativo entre Yo por vos y vos por otro (1676) de Agustín Moreto y la refundición de José Fernández Guerra, Ir contra el viento (1826), un dramaturgo y bibliófilo del siglo XIX. Esta refundición no ha sido estudiada anteriormente, de forma que ofreceremos un estudio comparativo con el objetivo de establecer las semejanzas y diferencias entre ambas e intentar justificar los cambios introducidos por el refundidor.
Notas para una historia de la pseudociencia en México: «Mi cura del agua», de Sebastian Kneipp, en la prensa mexicana (1891-1902)
Authors: Cortés Guadarrama Marcos
Published: December 2022

En este artículo se estudia la presencia del cura alemán, Sebastian Kneipp, y su famoso Método de hidroterapia o Mi cura de agua (Kempten, 1886) en la prensa mexicana de finales del siglo XIX. Desde los postulados de la historia de la lectura, se revisa la forma y contenido del libro; el porqué de su notoria popularidad que lo convirtió en un Bestseller de su tiempo. A continuación, se analiza el tratamiento que la prensa mexicana le dio a esta pseudociencia que no permeó en el discurso normativo de la medicina. Se concluye que, por el contrario, fue bien conocida por distintas comunidades de la sociedad y que sus referencias asentadas en la prensa –en traducciones de noticias internacionales, en la publicidad, en la caricatura y en la sátira política–, formaron parte de la construcción de una opinión pública y una identidad mexicana.
Importance of Right Nutrition for the Astronauts of Deep Space
Authors:   Scholar, Department of Nutrition, Seacom Skills University, Birbhum 731236, West Bengal, India., Banerjee Swapan
Published: December 2022

Essential food requirements for space food systems include food safety, palatability, safety, stability, variety, usability, and reliability. The space station administration always gives astronauts access to nutritious food like fruits, vegetables, and certain processed foods as a regular diet. The gravitational impacts are significantly reduced in a microgravity environment in deep space. As a result of microgravity, the eating implements like wise float away. The beverage packaging for the international space station is made of laminated foil and plastic. The article mainly talked about the food system engineering facilities and the classifications of space food according to their processing. The article also highlighted the standard menu in a space shuttle for American, Russian, and Chinese astronauts according to a pre-planned diet. There are various uses of food under the food processing system in the space shuttle, such as preparation and selection of food, planning, and serving of food, etc. Similarly, it is essential for extended shelflife food for Indian astronauts. Proper nutrition and food safety are critical for all astronauts to cope with deep space environments.
The Role of Ofelia Zepeda in the Tohono O’odham Language and Cultural Revitalization
Authors: Černý Miroslav
Published: December 2022

Tohono O’odham (formerly Papago), a Native American language spoken in southern Arizona and northern Mexico, has been frequently reported as endangered. The article aims to present efforts to revitalize and stabilize the language (and its culture), particularly the activities of Ofelia Zepeda, who is a member of the Tohono O’odham Indian Nation. Zepeda is a professor of linguistics at the University of Arizona in Tucson and has been contributing to the revival of her mother tongue, primarily as a linguist, language educator and activist. She is also known for her creative writing and incorporates Tohono O’odham into her poems.
Psicología de la salud con niños y adolescentes: Importante continuar avanzando
Authors: Fernández Martínez Iván
Published: December 2022

La infancia y la adolescencia representan periodos del desarrollo vital de sumatrascendencia los cuales, lamentablemente, no están exentos de la posibilidad dedesarrollar enfermedades físicas y problemas o trastornos a nivel psicológico durante sutranscurso. La Organización Mundial de la Salud (OMS, 2022) pone de relieve datos atener en cuenta, indicando que la mitad de los problemas de salud mental se inicianantes de los 14 años de edad, mientras que la mayoría de los casos no se detectan nireciben un tratamiento adecuado. Asimismo, destaca algunos problemas de salud queconsidera principales (p. ej., enfermedades infecciosas, traumatismos, obesidad, falta deactividad física, consumo de sustancias), incluyendo problemas de salud mental. Enrelación a esto último apunta que, a nivel mundial, un 16% de la carga de morbilidad ylesiones entre los 10 y 19 años estarían explicados por los trastornos de salud mental,considerándose la depresión entre las principales causas de enfermedad y discapacidaden adolescentes. Por ello, se enfatiza la conveniencia de ocuparse, desde edadestempranas, de los problemas de salud mental. No hacerlo puede tener consecuenciastanto en el período actual como en la edad adulta, con repercusiones negativas tanto ensu salud física y mental, así como en su calidad de vida.
Plan de marketing para el lanzamiento de un negocio de elaboración de mochilas canguros personalizadas para transportar perros de raza pequeña en Lima, Perú
Authors:   , Alarcon Carrasco Juan Yasser , Medina Quiroz Diego Eduardo , Ochoa Panduro Kevin
Published: December 2022

A lo extenso de este proyecto de investigación vamos a dar a conocer cómo será el desarrollo de este plan de marketing socialmente responsable, la cual tendremos como objetivo llevar al éxito. Hoy en día se toma en consideración a las mascotas parte del hogar y del núcleo familiar, es tanto el amor que sienten los dueños que estos atribuyen el título de padres hacia sus engreídos de cuatro patas. KEDIYA parte de una iniciativa de confort y seguridad hacia los perros de raza pequeña. Por ello, esta organización se dedicará a la comercialización de mochilas canguro, con diseños exclusivos y sofisticados. Puesto que, desarrollaremos un satisfactor cuya finalidad permita facilitar el traslado de los perros de raza pequeña, salvaguardando su bienestar y comodidad. Asimismo, se pudo determinar que existe un mercado con necesidades por cubrir con relación a los productos para perros, que haga énfasis únicamente al transporte de estos de una forma completamente exclusiva.
Predicción de parto vaginal aplicando los puntajes Grobman y Flamm en el Hospital Nacional Docente Madre Niño San Bartolomé 2021
Authors:   , Ildefonso Garcia Zoely Jackelyn
Published: December 2022

Objetivos del estudio: El objetivo será determinar la utilidad de los puntajes de Grobman y Flamm para la predicción de parto vaginal en pacientes con cesárea anterior en el Hospital Nacional Docente Madre Niño San Bartolomé (HONADOMANI) 2021. Metodología: diseño observacional, analítico, retrospectivo. La población en estudio será todas las gestantes con cesárea anterior del HONADOMANI, entre enero – diciembre 2021.
Comparación del espacio de la vía aérea faríngea en radiografías laterales de cabeza de individuos de clase I y clase II esquelética
Authors:   , Razo Huillca Santiago Bernardino
Published: December 2022

Objetivo: Comparar el espacio de la vía aérea faríngea (nasofaringe y orofaringe) a través del análisis de en radiografías laterales en pacientes de clase II esquelética comparado con un grupo control de clase I. Metodología: Este estudio fue de tipo observacional, descriptivo, transversal y prospectivo. Su muestra estuvo conformada por 60 radiografías laterales de cabeza distribuidas en 30 radiografías clase I (ANB 2°+/- 2°y maloclusión de clase I) y 30 radiografías clase II esquelética( ANB >5° y maloclusión clase II-1). En ellas se midió el espacio en mm. las vías aéreas de la orofaringe y nasofaringe a través del método de Mc Namara en radiografías laterales de cabeza. Resultados: El promedio de la orofaringe en clase I fue de 11.71mm ± 3.18mm. En el grupo de clase II fue de 10.73mm. ± 2.36mm. No se encontraron diferencias significativas (p=0.18). . El promedio de la nasofaringe en clase I fue de 18.45mm ± 4.11mm. En clase II fue de 19.10mm ± 3.89mm. No se encontraron diferencias significativas (p=0.53). Conclusión: El espacio en mm. de la nasofaringe presenta valores similares en milímetros en sujetos con maloclusión Clase I y Clase II. No existe diferencia en el espacio en mm. de la orofaringe entre sujetos de maloclusión Clase I y Clase II.
Criterios de diseño arquitectónico en base a las necesidades espaciales de los alumnos de beca 18 de la Universidad Científica del Sur
Authors:   , Rivera Rodriguez Leydi Ana , Uribe Alhuay Patricia Tania
Published: December 2022

A partir del 2012 el estado peruano promueve el programa Beca 18, siendo una gran oportunidad para que los alumnos de bajos recursos de todas las regiones del Perú puedan estudiar en universidades prestigiosas, ubicándose la mayoría en Lima. Esto trae consigo la problemática de buscar un espacio donde habitar siendo muchos de ellos los alojamientos espontáneos con bajo nivel de confort. Por ello, nos planteamos la siguiente pregunta: ¿Cuáles serían los criterios de diseño arquitectónico que mejor respondan a las necesidades espaciales residenciales de los alumnos del programa Beca 18 de la Universidad Científica del Sur? La metodología de esta investigación es de enfoque mixto, con un diseño transformativo concurrente. Asimismo, por medio del cuestionario se halló que los actuales alojamientos temporales no responden a las necesidades del estudiante por funcionalidad, seguridad, satisfacción ni confort térmico; además, por la ficha de observación directa se determinó los ambientes requeridos por los estudiantes y se analizó los ambientes más utilizados por ellos. Finalmente, con el análisis de referentes se determinó la infraestructura adecuada para los estudiantes, concluyendo que una residencia universitaria es la infraestructura residencial polivalente indispensable para satisfacer las necesidades espaciales residenciales del estudiante.
Análisis de las TICs como herramienta educativa en la carrera de Medicina Humana de una universidad privada en tiempos de pandemia por covid-19, Lima, Perú 2021
Authors:   , Ordaya Gonzales Karina Mercedes
Published: December 2022

Objetivo: Describir el uso de TICs como herramienta de aprendizaje en la carrera de medicina humana. Metodología: Se realizó un estudio cuantitativo, observacional, descriptivo y transeccional. Se consideró una población de 277 alumnos universitarios de 18 a 25 años de los ciclos II, III, IV, V, VI y VII que se encontraron llevando clases virtuales durante el periodo 2021-2 de una Universidad Privada de Lima-Perú. Los cuales fueron tomados en su totalidad. Los datos obtenidos fueron mediante un cuestionario virtual. Resultados: Se evidenció un alto nivel de satisfacción al usar recursos tecnológicos; siendo mayor en mujeres (54%). Con relación a barreras y desafíos, el 64% presentó problemas técnicos en sus clases virtuales, el 60% consideró la disponibilidad de la información y acceso a internet como la mayor ventaja. Asimismo, el 55% consideró que favorecen al aprendizaje colaborativo. El 83% presentó problemas de conexión. Además, un 64% consideró su utilización como acceso a muchas distracciones. El 52% lo consideró fácil de utilizar. Conclusión: El uso de TIC generó un aporte positivo en la educación, incorporando nuevos métodos y herramientas tecnológicas.
Wnt activation-induced disturbance of cell competition causes diffuse invasion of transformed cells through upregulation of NF-κB-mediated MMP21
Authors: Nakai Kazuki , Lin Hancheng , Yamano Shotaro , Tanaka Shinya , Kitamoto Sho , Sakuma Kenta , Kurauchi Junpei , Akter Eilma , Konno Masamitsu , Koseki Jun , Takahashi Hirotaka , Yokoyama Hideshi , Shiraki Yukihiro , Enomoto Atsushi , Abe Sohei , Hayakawa Yoku , Ushiku Tetsuo , Mutoh Michihiro , Fujita Yasuyuki , Kon Shunsuke
Published: December 2022

Normal epithelial cells exert their competitive advantage over RasV12-transformed cells and eliminate them into the apical lumen via cell competition. However, the internal or external factors that compromise cell competition and provoke carcinogenesis remains unknown. In this study, we examined the effect of sequential accumulation of gene mutations, mimicking multi-sequential carcinogenesis on RasV12-induced cell competition in intestinal epithelial tissues. Consequently, we found that directionality of RasV12-cell extrusion in Wnt-activated epithelia is reversed, and transformed cells are delaminated into the basal lamina via non-cell autonomous MMP21 upregulation. Subsequently, diffusively infiltrating, transformed cells develop into highly invasive carcinomas. Elevated production of MMP21 is elicited partly through NF-κB signaling, blockage of which restores apical elimination of RasV12 cells. We further found that the NF-κB-MMP21 axis is significantly bolstered in early colorectal carcinoma in humans. Collectively, this study shows that cells with high mutational burdens exploit cell competition for their benefit by behaving as unfit cells, endowing them with an invasion advantage.
Kano Perspective Method: Analysis of Main Factors that Affects Patients’ Satisfaction in Attempt to Improve Dental Treatment Qualities in Government Hospitals
Authors: Akbar Fuad Husain , Mattoreang Ainun Habi
Published: December 2022

Background: Research on patient’s satisfaction is rarely conducted in hospitals. Most studies on satisfaction focused on variables such as service quality and satisfaction with medical services and their relationship, whilst only several of them explored variables regarding patient satisfaction. Assessment of the quality of dental care services is still relatively primitive. Thus, this study integrated the structure-process-outcome framework from Donabedian, and the two-dimensional quality model from Kano, to identify the main factors of patient satisfaction in attempt to improve dental care services.
Methods:This was an analytic observational study with a cross sectional design. Patients aged 12 to 65 years, who visited the dental clinic in designated research hospitals for dental treatment at the time of the study were recruited as subjects. Afterwards, an adapted Kano's perspective (Kano's method) questionnaire was given to respondents. The questionnaire consisted of a paired question, there were functional and dysfunctional questions.
Results: After conducting research at South Sulawesi’s government hospitals, 303 respondents, who visited the dental clinic at the research designated hospital, were then scouted for this study. From the patient's point of view, most of the service elements were classified as must-be attributes, namely 12 elements. In addition, 9 elements were classified as one-dimensional attributes (one size) and 7 elements were classified as attractive attributes; the rest were classified as indifferent (neutral) attributes.
Conclusion: Overall, the patients were positively satisfied with all elements of the service carried out by the dental care sector of the hospital studied. However, there were some elements of service that need to improve because due to their low level of assessment.
The influence of antihypertensive drugs on hemodynamic parameters of cerebral arteries assessed by transcranial Doppler
Authors: Machado Michel , Muela Henrique Cotchi Simbo , Costa-Hong Valeria Aparecida , Panerai Ronney B. , Moraes Natalia C. , Memoria Claudia M. , Bor-Seng-Shu Edson , Nitrini Ricardo , Bortolotto Luiz Aparecido , Nogueira Ricardo de C.
Published: December 2022

Arterial hypertrophy and remodeling are adaptive responses present in the systemic arterial hypertension (SAH). As a result, antihypertensive drugs (AHD) begin to play an important role in controlling the cerebral blood flow. To evaluate the influence of AHD on cerebral hemodynamic parameters (CHP). Three groups of patients were compared: hypertensive with systolic blood pressure (SBP) < 140 and diastolic blood pressure (DBP) < 90 mmHg (n = 54), hypertensive with SBP > 140 or DBP > 90 mmHg (n = 31) and normotensive (n = 30). Simultaneous measurements of systemic blood pressure (BP) and middle cerebral artery (MCA) blood flow velocity (CBFV) were obtained from digital plethysmography and Transcranial Doppler. The use of diuretics (p = 0.047) and α-agonists (p = 0.009) reduced the pulsatility index (PI) among uncontrolled hypertensives, but did not change their arterial stiffness in relation to the others groups (RAP 1.7 [± 0.7], p < 0.001). There was no correlation between ADH and other CHP, although the RAP of controlled hypertensives was comparable to that of normotensives. Among uncontrolled hypertensives, the use of AHD with direct vasodilating action actively reduces PI, so it does not reflect a real cerebrovascular resistance of adaptive histological changes. This effect seems to be smaller among controlled hypertensives, due to their lower arterial stiffness, probably resulting from the attenuation of these changes.
Subjective and objective assessment of sleep quality during each trimester of pregnancy: a prospective observational study
Authors: Kiyoko Miyauchi , Takayuki Abe , Kaoru Fujimoto , Junko Tabata , Kiwamu Ohtaka , Kazuya Makita
Published: December 2022

Background
Sleep disturbances due to hormonal imbalance are common during pregnancy. Studies have suggested that poor sleep quality in pregnant women can lead to perinatal abnormalities; therefore, the need of the hour is to determine the actual circumstances of sleep during pregnancy from an early stage, and provide support for better sleep quality. Therefore, the present study aimed to assess sleep quality by objective assessment using an actigraph and subjective assessment using a questionnaire for sleep during each trimester of pregnancy, and to elucidate how sleep quality changed from the first to the third trimester of pregnancy.
Methods
A longitudinal questionnaire survey and sleep measurements using actigraph were conducted at three time points, during the first, second, and third trimester, of pregnancy for primiparous women who had conceived naturally.
Results
During the first trimester of pregnancy, there was no “feeling of being refreshed when waking up in the morning,” and there was a decline in mental function. During the second trimester of pregnancy, a positive correlation between morning sickness and sleep quality (r = 0.59, p = 0.001) was observed. Sleep quality was the worst during the third trimester, with the shortest total sleep time (382.6 ± 26.3 min, F = 11.7, p = 0.0001) and poor sleep efficiency (93.9%±3.2%, F = 4.1, p = 0.0029). Physical function score was also poor. Regarding minor troubles that affected sleep efficiency, back pain (r = 0.47, p = 0.03) and leg cramps (r = 0.57, p = 0.01) exhibited significant correlation with sleep efficiency in the third trimester of pregnancy.
Conclusions
Poor sleep during pregnancy begins from the first trimester; if minor troubles such as morning sickness continue in the second trimester, sleep quality is greatly affected. Furthermore, during the third trimester of pregnancy, low back pain and leg cramps are more likely to occur due to the increase in the abdominal area, and may interfere with sleep.
A pilot study to assess the impact of Aboriginal and Torres Strait Islander cultural humility webinars on Australian medical school students
Authors: Buhagiar Ryan , Lu Anton , Liu Sue , Sahadevan Shrida , Schulz Lucy May , Ghosh Joydeep , Yeoh Alexandra
Published: December 2022

Background
The Aboriginal and Torres Strait Islander Health Curriculum Framework has provided evidence-based support to higher education providers to deliver safe and well-informed cultural humility education. However, there is currently a scarcity of evidence surrounding the efficacy and impact of cultural humility education. This study will contribute to a quality evidence base assessing the impact of cultural humility and responsiveness interventions on Australian medical students.
Methods
A pilot study was conducted following a group of Australian medical students who attended an educational Indigenous health (IH) culturally responsive webinar. Recruitment was conducted via the webinar hosts’ social media pages. One pre-webinar and two post-webinar questionnaires were sent to attendees. To assess participants’ retention of information one post-webinar survey was sent out immediately after the webinar and another three months after the webinar. These questionnaires were designed to reflect pre-determined learning objectives for the webinar. A focus group was selected from the pool of participants for a qualitative analysis of the webinar’s impact.
Results
Twenty-six participants were included in the final analysis. Most of the participants were clinical students between 18–24 years old who did not identify as Aboriginal and/or Torres Strait Islander. There was an insignificant increase (p = 0.196) in mean participant total score from pre-intervention (M = 0.45, SD = 0.11) to the immediate post-intervention score (M = 0.48, SD = 0.13). However, stratification based on learning outcomes showed some improvement between pre- and immediate post-webinar knowledge for one learning outcome exploring the links between health and education.
Conclusions
There was a significant increase in knowledge and understanding for the learning outcome that explored the links between health and education. We attribute this partly to the engaging and conversational delivery style of the webinar presenters. The importance of facilitators that encourage reflective teaching should not be understated. Our results highlight the unequivocal potential that cultural humility webinars can have on medical students’ understanding of the Aboriginal and/or Torres Strait Islander health landscape. This pilot study warrants further research on a larger population.
Gamification in laparoscopic training: a randomized, controlled study
Authors: Zwimpfer Tibor Andrea , Wismer Claudine , Geissler Franziska , Oehler Robert , Geiger James , Schötzau Andreas , Fellmann-Fischer Bernhard , Heinzelmann-Schwarz Viola
Published: December 2022

Background: The gamification of laparoscopy using physical computing is an attempt to incentivize training and generate data for analysis. Here, we evaluate a laparoscopic dexterity game box (LDGB) in a pelvitrainer model for laparoscopic training by comparing the performance of the validated Laparoscopic Skills Training and Testing 3 (LASTT 3) exercise from the Gynaecological Endoscopic Surgical Education and Assessment (GESEA) program.
Methods: Sixty medical students with no experience in laparoscopy were randomized into three groups with 20 participants in each. All three groups performed four runs of the validated LASTT 3 exercise. Group A completed 40 runs with the LDGB, Group B completed 20 runs, and Group C completed no runs. Task completion time and the number of errors made were recorded. The Wilcoxon test and mixed-effects models were used to analyze the results. After completing the exercises, participants answered questions concerning the LDGB and their performance.
Results: The students improved their performance after using the LDGB. They were significantly faster at performing the LASTT 3 exercise using the LDGB, with a mean difference of 40s (P=0.013) between Group A (185s) and Group C (225s), and 26s (P=0.105) between Group B (199s) and Group C (225s). There were no significant differences between the mistakes made. The students were significantly faster (P<0.001) in completing the LDGB exercise during a second repetition, with fewer mistakes made (P<0.001). The LDGB was rated as intuitive by 86.4% of the participants.
Conclusions: Students using the LDGB achieved better results in the GESEA exercise. These benefits were accompanied by subjective advantages noted by the students. Gamification presents an opportunity to improve laparoscopic performance.
Integrative analysis the characterization of LAMBs in predicting the prognosis and the immunotherapy response of cancers
Authors: Tao Yong , Yuan Danping , Shi Yijiu , Cao Yuepeng , Liu Minmin
Published: December 2022

Background:
Laminin subunit betas (LAMBs) are the major noncollagenous constituent of basement membranes that implicated in biological functions such as cell adhesion, metastasis. However, few studies have systematically analyzed the prognostic value and immune characteristics of LAMBs in pan-cancer types.
Methods:
A pan-cancer comprehensive analysis of LAMBs in expression levels, protein localization, structure, mutations and methylation were explored. Next, Cox regression and Kaplan-Meier method were applied to analyze the prognostic role of LAMBs in pan-cancer. Protein-Protein Interaction (PPI) analysis was performed in the GeneMANIA database, and enrichment analysis was predicted signaling pathways were identifified by using Gene Ontology (GO), Kyoto Encyclopedia of Genes (KEGG) and gene set variation analysis (GSVA) analysis. The immune characteristics of LAMBs in the tumor microenvironment were evaluated via ImmuCellAI and TIMER 2.0. was the main platform to investigate the tumor associated macrophages (TAMs) related to LAMBs in pan-cancer, especially M2-like TAMs. In addition, single-cell sequencing analysis and tracking tumor immunophenotype (TIP) were also conducted to validate the interaction immune role of LAMBs with macrophages in cancers. Furthermore, the immunoregulators, tumour mutational burden (TMB) and microsatellite instability (MSI) was performed to evaluate the immune response role of LAMBs in cancers. Finally, the immunotherapy response and drug sensitive small molecule drugs based on LAMBs expression were predicted.
Results:
The expression, mutation and methylation of LAMBs was aberrantly expressed in most cancer types and exhibited prognosis predictive ability in various cancers. In addition, our results also showed that LAMBs was signifificantly correlated with immune-activated (including pathways and biological processes), immune cell infifiltrations, immunoregulator expressions, TMB and MSI. Importantly, analysis of an independent immunotherapy cohorts revealed that low-risk patients had better immunotherapy responses and prognosis than high-risk patients in some cancers. Furthermore, the immunotherapy response and sensitive small molecule drugs which correlate with LAMBs expression in different cancer types, had a potent capability to predict immunotherapy response in pan-cancers.
Conclusions:
LAMBs expression may contribute to increased infiltration of TAMs, which not only acted as a potent prognostic factor to predict the clinical outcomes of cancer patients but was also a promising immunotherapy predictive biomarker for cancer patients treated with immune-checkpoint inhibitors (ICIs).
Risk factors for poor outcomes of mechanical thrombectomy after anterior circulation large vessel occlusion-related acute ischemic strokes
Authors: Li Jinze , Duan Jinfeng , Zhang Luojin , Xu Zhihua , Yang Benqiang , Li Xiaoqiu , Duan Yang
Published: December 2022

METHODS
Patients (N = 313) undergoing MT within a specified time window after onset of ACLVO-related AIS provided clinical and radiologic data for analysis. Clinical endpoints were symptomatic intracranial hemorrhage (sICH) and 90-day functional outcome (scored by modified Rankin Scale [mRS]). Logistic regression was invoked to identify links between clinical/radiologic parameters and clinical outcomes.
RESULTS
Mean age of patients was 64.0 ± 12.2 years, and women accounted for 29.4%. The median National Institute of Health Stroke Scale [NIHSS] score was 15.2 (interquartile range [IQR]: 12–18). In multivariable analysis, initial Alberta Stroke Program Early CT Score (ASPECTS) determination (odds ratio [OR] = 0.748, 95% confidence interval [CI]: 0.604–0.926; p = 0.008), hyperdense middle cerebral artery sign (HMCAS) (OR = 0.463, 95% CI: 0.238–0.899; p = 0.023), early imaging signs of infarct (OR = 2.837, 95% CI: 1.285–6.263; p = 0.01), baseline NIHSS score (OR = 1.195,95% CI: 1.091–1.309; p < 0.001), age (OR = 1.082,95% CI:1.047–1.118; p < 0.001), and glycosylated hemoglobin (HbA1c) concentration (OR = 1.293, 95% CI: 1.084–1.543; p = 0.004) proved independently predictive of poor clinical outcomes (mRS scores > 2).
CONCLUSIONS
A number of factors, including initially determined ASPECTS, HMCAS, early imaging signs of infarct, baseline NIHSS score, age, and HbA1c concentration, appear to predict poor outcomes of MT after ACLVO-related AIS.
Uncertainty and probability in neonatal end-of-life decision-making: A mixed method study analysing conversations with families of critically ill newborns
Authors: Limacher Regula , Fauchère Jean-Claude , Gubler Deborah , Hendriks Manya Jerina
Published: December 2022

Background: A significant number of critically ill neonates face potentially adverse prognoses and fulfil the criteria for perinatal palliative care. When counselling parents about the critical health condition of their child, neonatal healthcare professionals require extensive skills and competencies in palliative care and communication. Thus, this study aimed to investigate the communication patterns and contents between neonatal healthcare professionals and parents of neonates with life-limiting or life-threatening conditions regarding treatment options such as curative and palliative care in the decision-making process.
Methods: A mixed methods research design was employed with a qualitative and quantitative approach to analysing audio-recorded conversations between neonatal team and parents.Eight critically ill neonates and a total of 16 conversations from two Swiss level III neonatal intensive care units were included.
Results:Three main themes were identified: the weight of uncertainty in diagnosis and prognosis, the decision-making process, and palliative care. Uncertainty was observed to impede the discussion about all options of care, including palliative care. Regarding decision-making, neonatologists oftentimes conveyed to parents that this was a shared endeavour. However, parental preferences were not ascertained in the conversations analysed. In most cases, healthcare professionals were leading the discussion and parents expressed their opinion reactively to the information or options received. Only few couples proactively participated in decision-making. With regards to palliative care, oftentimes the continuation of therapy was the preferred course of action of the healthcare team and the option of palliative care was not mentioned. However, once the option for palliative care was raised, the parents' wishes and needs regarding the end-of-life care of their child were obtained, respected, and implemented by the team.
Conclusion: Although shared decision-making was a familiar concept in Swiss neonatal intensive care units, parental involvement in the decision-making process illustrated a somewhat different and complex picture. Strict adherence to the concept of certainty might impede the process of decision-making, thereby not discussing palliation and missing opportunities to include parental values and preferences.
Fragile X Messenger Ribonucleoprotein 1 (FMR1), a novel inhibitor of osteoblast/osteocyte differentiation, regulates bone formation, mass, and strength in young and aged male and female mice.
Authors: Plotkin Lilian , Deosthale Padmini , Balanta-Melo Julian , Creecy Amy , Liu Chongshan , Marcial Alejandro , Morales Laura , Cridlin Julita , Robertson Sylvia , Okpara Chiebuka , Sanchez David , Ayoubi Madhi , Lugo Joaquin , Hernandez Christopher , Wallace Joseph
Published: December 2022

Fragile X Messenger Ribonucleoprotein 1 (FMR1) gene premutations lead to fragile X syndrome, cognitive disorders, and, in some individuals, scoliosis and craniofacial abnormalities. Four-month-old male FMR1-deficient mice exhibit a mild increase in cortical and cancellous femoral bone mass. However, consequences of FMR1-deficiency in bone of young and aged and of male and female mice and the cellular basis of the skeletal phenotype remain unknown. We found that FMR1-deficiency results in improved bone properties with higher bone mineral density in both sexes and in 2- and 9-month-old mice. But cancellous bone mass is higher only in females, whereas, cortical bone mass is higher in 2- and 9-mo males, but higher in 2- and lower in 9-month-old female FMR1-deficient mice. Further, male bones show higher biomechanical properties in 2-month-old, and females at both ages. FMR1-deficiency increases osteoblast number, mineralization, and bone formation and osteocyte dendricity and gene expression in vivo, ex vivo, and in vitro, without affecting osteoclasts in vivo or ex vivo. Thus, FMR1 is a novel osteoblast/osteocyte differentiation inhibitor, and its absence leads to age-, site- and sex-dependent higher bone mass and strength.
Post Introduction Evaluation of the Malaria Vaccine Implementation Programme in Ghana, 2021
Authors: Adjei Michael Rockson , Amponsa-Achiano Kwame , Okine Rafiq , Tweneboah Peter Ofori , Sally Emmanuel Tetteh , Dadzie John Frederick , Osei-Sarpong Fred , Adjabeng Michael Jeroen , Bawa John Tanko , Bonsu George , Antwi-Agyei Kwadwo Odei , Kaburi Basil Benduri , Owusu-Antwi Felicia , Juma Elizabeth , Kasolo Francis Chisaka , Asiedu-Bekoe Franklin , Kuma-Aboagye Patrick
Published: December 2022

Background
Malaria remains a public health challenge in Sub-Saharan Africa with the region contributing to more than 90% of global cases in 2020. In Ghana, the malaria vaccine was piloted to assess the feasibility, safety, and its impact in the context of routine use alongside the existing recommended malaria control measures. To obtain context-specific evidence that could inform future strategies of introducing new vaccines, a standardized post-introduction evaluation (PIE) of the successes and challenges of the malaria vaccine implementation programme (MVIP) was conducted.
Methods
From September to December 2021, the WHO Post-Introduction Evaluation (PIE) tool was used to conduct a mix method evaluation of the pilot introduction of the malaria vaccine in Ghana. To ensure representativeness, study sites and participants from the national level, 18 vaccinating districts, and 54 facilities from the seven pilot regions were purposively selected. Data was collected using a questionnaire based on the PIE tool. We performed summary descriptive statistics on quantitative data, thematic analysis on qualitative data, and triangulation of the results from both sets of analyses.
Results
About 90.7% (49/54) of health workers stated that the vaccine introduction process was smooth and contributed to an overall improvement of routine immunization services. About 87.5% (47/54) of healthcare workers, and 95.8% (90/94) of caregivers accepted RTS,S malaria vaccine. Less than half [46.3%; (25/54)] of the healthcare workers received training prior to the introduction but almost all [94.4%; (51/54)] were able to constitute and administer the vaccine appropriately. About 92.5% (87/94) of caregivers were aware of the RTS,S introduction but only 44.0% (44/94) knew the number of doses needed for maximum protection. The initial phase was characterized by low vaccine uptake due to caregiver hesitancy, but coverage improved steadily over the pilot period.
Conclusions
The malaria vaccine has been piloted successfully in Ghana. Intensive advocacy; community engagement, and social mobilization; and regular onsite supportive supervision are critical enablers for successful introduction of new vaccines. Stakeholders are convinced of the feasibility of a nationwide scale up using a phased subnational approach taking into consideration malaria epidemiology and global availability of vaccines.
Seasonal Evaluation of Eastern Mediterranean Basin Ephemeroptera (Insecta) Fauna and Water Quality with Physicochemical Parameters and Benthic Metrics
Authors: ÖZTÜRK Selda , ÇİÇEK Erdoğan , NEGİZ Mehmet Güvenç , KOYUNCUOĞLU Serdar
Published: December 2022

In this study, it is aimed to reveal the ecological water quality of the stations by evaluating the Eastern Mediterranean Basin Ephemeroptera fauna and water quality through the physicochemical variables at the determined stations and the benthic metrics developed for the Eastern Mediterranean Basin. For this purpose, field studies were carried out by determining 20 different localities in the spring, summer and autumn seasons in 2019. A total of 965 individuals were examined and 17 species belonging to seven families were identified. Species diversity at stations is highest and lowest, respectively, according to Shannon-Wiener (H) values; in the spring period at the 6th (1.55) and 9th (0.15) stations, in the summer period at the 15th (1.46) and 9th (0.29) stations, in the autumn period at the 12th (1.01) and 3rd (0.22) stations were calculated. According to cluster cluster analysis; while the highest similarities were calculated (100%) between the 1st, 2nd, 8th stations and the 10th and 19th stations, including the same species, it was determined that the 18th station differed from all other stations. According to ANOSIM results; while a significant difference was observed between the spring and summer and autumn seasons in terms of the distribution of the species, no significant difference was found between the summer and autumn seasons. According to the MANOVA result, while there was no significant difference between the spring and autumn seasons in terms of temperature variable, it was found to be significant in other seasons combinations. While the pH variable created a significant difference between summer and autumn seasons, it did not make a difference in other seasons combinations. Dissolved oxygen and total nitrogen variables showed significant differences in all season combinations. In terms of the final index results calculated on benthic metrics; determined the 1st, 9th, 11th, 13th, 18th and 20th stations were moderate, the 7th and 8th stations were poor, while all other stations were good or high water quality.
Customizing the structure and chemical composition of ultralight carbon foams for superior microwave absorption performance
Authors: Cheng Tingting , Guo Yuying , Xie Yuxin , Zhao Laibin , Wang Ting , Meng Alan , Li Zhenjiang , Zhang Meng
Published: December 2022

Developing biomass-derived three-dimensional porous carbon materials (porous carbon foam, PCF) has become a common strategy to obtain lightweight and efficient electromagnetic microwave-absorbing materials. Without the introduction of a template and subsequent activation process, several ultra-lightweight honeycomb PCF samples were successfully prepared from dried ballonflower (DB) by simple calcination, and the calcination temperature plays a decisive role in regulating the pore size, composition and microwave absorption properties of PCF samples. Furthermore, it is worth noting that different cutting directions also affected the hole size of the PCF sample as well as the microwave absorption performances. Under the combined effects of multiple reflections and scattering of PCF porous structure, dipole polarization of abundant heterogeneous atoms and good conductive loss of carbon material, the vertical cutting sample PCF-900V exhibits optimal microwave absorption performances with the minimal reflection loss (RLmin) value of -46.95 dB at 1.46 mm thickness and the effective absorption bandwidth (EAB) value of 5.52 GHz at 1.72 mm matching thickness respectively, indicating its great potential application as a promising lightweight and efficient microwave absorbing material.
Clinical Observation of Tear Film Breakup Time with A Novel Smartphone-Attachable Technology
Authors: Zhang Xiaoran , Shen Jiawei , Kang Zhen , Chene Andrew , Cao Qian , Xue Chunyan
Published: December 2022

Purpose
To demonstrate the practicability of a portable instrument in assessing tear film breakup time (TFBUT): a lens attachment for smartphones (LAS).
Methods
By applying LAS in combination with the iPhone 12 pro, and a recordable slit-lamp microscope, we obtained TFBUT videos from 58 volunteers. The comparison between the conventional slit-lamp microscope and LAS by an experienced ophthalmologist. Moreover, we also invited an ophthalmic postgraduate student and an undergraduate student with no clinical experience to assess TFBUT in those videos. The inter-observer reliability was assessed using intraclass correlation coefficients (ICC).
Results
The TFBUT of 116 eyes in total was recorded. Reliability indexes were adequate. The Spearman’s correlation analysis suggested a strong correlation between the 2 modalities (Spearman’s r = 0.941, 95% confidence interval [CI] = 0.906–0.963). The average intraclass correlation coefficient showed a substantial agreement among the 3 observers (LAS ICC = 0.911, p < 0.005; slit-lamp microscope ICC = 0.895, p < 0.005). A high concordance was observed in TFBUT, when assessed by an ophthalmologist and an ophthalmic postgraduate student (LAS ICC = 0.949, p < 0.005; slit-lamp microscope ICC = 0.940, p < 0.005).
Conclusions
Compared with the conventional slit-lamp microscope, the LAS has sufficient validity for evaluating TFBUT in clinics or at home.
Lyapunov-based PID adaptive controller design for Buck converter
Authors: ghamri Seyyed mortaza , khavari fatemeh , mollaee hassan
Published: December 2022

In this paper, a Lyapunov-based model reference ProportionalIntegrated-Derivative(PID) is designed using this approach for a DC\DC Buck
converter. However, under a wider range of disturbances, the PID strategy is not suitable for practical applications, and the parameters must be tuned again
for more reliable operations. To this end, a Lyapunov deﬁnition-based adaptivemechanism is adopted for the PID strategy, which can increase the stabilityand robustness of this scheme under various disturbances. Moreover, the system is considered a black-box without the need for accurate mathematical
modeling of the system that can result in a lower computational burden as
well as ease of implementation. The Lyapunov concept is a modern adaptive
algorithm that can ﬁnd optimal answers in shorter periods with more accuracy
and reliable stability insurance. To examine the strength of this method,
conventional Fractional-order PID (FOPID) and PID control techniques are
also tested to be compared with this work using the PSO algorithm to
tune their parameters. Finally, the results related to both simulations and
experimental outputs are tested, showing faster dynamics and signiﬁcant
robustness of Lyapunov-based PID strategy in diﬀerent challenging scenarios.