bluuebunny/crossref_metadata_2025 huggingface dataset:
An efficient numerical method based on QSC for multi-term variable-order time fractional mobile-immobile diffusion equation with Neumann boundary condition
Authors: Liu Jun , Liu Yue , Yu Xiaoge , Ye Xiao
Published: February 2025

In this work, we aimed at a kind of multi-term variable-order time fractional mobile-immobile diffusion (TF-MID) equation satisfying the Neumann boundary condition, with fractional orders $ \alpha^{m}(t) $ for $ m = 1, 2, \cdots, P $, and introduced a QSC-$ L1^+ $ scheme by applying the quadratic spline collocation (QSC) method along the spatial direction and using the $ L1^+ $ formula for the temporal direction. This new scheme was shown to be unconditionally stable and convergent with the accuracy $ \mathcal{O}(\tau^{\min{\{3-\alpha^*-\alpha(0), \ 2\}}} + \Delta x^{2}+\Delta y^{2}) $, where $ \Delta x $, $ \Delta y $, and $ \tau $ denoted the space-time mesh sizes. $ \alpha^{*} $ was the maximum of $ \alpha^{m}(t) $ over the time interval, and $ \alpha(0) $ was the maximum of $ \alpha^{m}(0) $ in all values of $ m $. The QSC-$ L1^+ $ scheme, under certain appropriate conditions on $ \alpha^{m}(t) $, is capable of attaining a second order convergence in time, even on a uniform space-time grid. Additionally, we also implemented a fast computation approach which leveraged the exponential-sum-approximation technique to increase the computational efficiency. A numerical example with different fractional orders was attached to confirm the theoretical findings.
Repurposing of paroxetine and fluoxetine for their antibacterial effects against clinical Pseudomonas aeruginosa isolates in Egypt
Authors: Baraka Kholoud , Abozahra Rania , Khalaf Eman , Bennaya Mahmoud Elsayed , Abdelhamid Sarah M.
Published: February 2025

Background

Drug repositioning has emerged as a promising strategy for assessing its antimicrobial efficacy in treating infectious diseases.

Methods

Seventy-five samples were collected and investigated for the presence of Pseudomonas aeruginosa. Antibiotic resistance, hemolytic activity, twitching motility, and biofilm formation were assessed. lasI and lasR genes were detected using conventional PCR. Minimum inhibitory concentrations of paroxetine, fluoxetine, and levofloxacin were determined by broth micro-dilution. The fractional inhibitory concentration index was calculated to assess the interaction between fluoxetine/levofloxacin and paroxetine/levofloxacin combinations. Half the MIC values of the drugs were selected for inhibitory effect assessment for virulence factors. Antibacterial and healing effects of fluoxetine were investigated on 30 male albino rats using a digital camera, bacterial count, and histological examination.

Results

Our 25 P. aeruginosa isolates were highly drug-resistant. 80%, 92%, and 80% of isolates were positive for twitching motility, hemolysis, and biofilm formation, respectively. 92% of isolates were positive for lasI gene and 96% for lasR gene. MICs of fluoxetine and paroxetine ranged from 32 to 512 µg/mL and MICs of levofloxacin ranged from 1 to 256 µg/mL. A synergistic outcome was observed in both combinations. Biofilm formation, twitching motility, and hemolysis were inhibited by paroxetine and fluoxetine in the majority of isolates. Fluoxetine/levofloxacin and paroxetine/levofloxacin combinations inhibited twitching motility, hemolysis, and biofilm formation in all isolates. Enhanced wound healing was observed in rats treated with fluoxetine and levofloxacin, with the fluoxetine/levofloxacin combination group demonstrating the most significant wound-healing effect. Bacterial count decreased in rats treated with levofloxacin, fluoxetine, and the levofloxacin/fluoxetine combination. Histological examination revealed higher wound healing in the levofloxacin-treated group than the fluoxetine group, and the combination treatment group displayed the fastest rate of wound healing.

Conclusions

Paroxetine and fluoxetine showed considerable antibacterial inhibitory effects against multi-drug resistant P. aeruginosa isolates. Fluoxetine showed significant improvement in anti-inflammatory effects and wound healing. To the best of our knowledge, this is the first Egyptian study to investigate the repurposing of paroxetine and fluoxetine as antibacterial agents. Further studies are needed to investigate their applicability as antibacterial agents as single agents or in combination with other antibiotics.
Du développement à l’effacement : les devenirs du paysage industriel de la vallée du Gier (France)
Authors: Périnaud Cléméntine , Ramon Maxence , Dendievel André-Marie , Frioux Stéphane
Published: February 2025

Reliant l’agglomération de Saint-Étienne à l’ouest, à la vallée du Rhône à l’est, la vallée du Gier constitue un pôle historique de l’industrie de l’acier où, à côté de quelques grands établissements hérités de la période industrielle (notamment Industeel, ex-Marrel Frères), perdure un tissu de PME-TPE dédié à la transformation des métaux. S’appuyant sur différents travaux de recherche en géographie et histoire environnementale, cet article présente les recompositions des paysages industriels de la vallée du Gier du milieu du XIXe siècle jusqu’à aujourd’hui. La désindustrialisation a conduit à de nombreuses destructions du bâti industriel qui se poursuivent. Cependant, la part relative des espaces affectés aux activités productives demeure forte dans la vallée avec un accroissement continu de leur superficie, ce qui n’empêche pas leur banalisation paysagère et sociale. Ainsi, les formes de réinvestissements économiques et urbains des espaces industriels hérités apparaissent très inégales, et rares sont les sites historiques désaffectés concernés par des programmes de valorisation patrimoniale. Les projets urbains privilégiant le réinvestissement productif y constituent à ce jour une voie privilégiée de conservation des paysages industriels hérités.
Paysage industriel et systématisme : les batavilles avec et sans l’usine
Authors: Brichler Antoine
Published: February 2025

Bata est une entreprise fabriquant des chaussures qui a construit à travers le monde, plusieurs villes-usines durant l’entre-deux-guerres, dans un grand systématisme, autour de bâtiments (de production, d’habitation, de services…) conçus sur le même modèle dans la ville-mère de ces villes-usines, Zlín, aujourd’hui en Tchéquie. Un paysage Bata, systématiquement répété et très reconnaissable, se constitue donc à partir de ces villes-usines, dans de nombreux pays. À la fin du XXème siècle, les différentes usines ferment ou se désengagent du paternalisme, laissant ces villes-usines orphelines.La fermeture de la partie productive du système pose alors des questions sur le devenir de ce paysage bien spécifique. Via l’utilisation d’un échantillon de villes-usines en Europe de l’Ouest, Europe centrale, et Amérique du Nord, ce travail cherche à présenter des éléments de réponse à la problématique suivante : que devient le paysage des villes-usines de l’entreprise Bata plus de 20 ans après la fermeture des usines ?
Miquel Barceló ou le musée en mouvement
Authors: Couturas Myriam
Published: February 2025

A great explorer of museums, as shown by his numerous sketchbooks, Miquel Barceló constantly ponders how to display his works of art. From studio to exhibitions, he invariably plays with the relationship between the work and the space hosting it. It represents a core dimension of his artistic activity. In this article, we will explain that this work leads to open up the enclosed space the museum is, heightening the meanings connected to this specific space.
Le musée Reina Sofía et Jaume Plensa : une esthétique de la transparence
Authors: Heredia Martine
Published: February 2025

Según el deseo de estar abiertos al mundo y de desarrollar el ideal del acceso democrático a la cultura, el Museo Reina Sofía de Madrid ha realizado la deslocalización del sitio a otra escala y en otro espacio abierto a todos. El objetivo es transformar y prolongar la relación entre arte, lugar y su anclaje en el espacio urbano. Es en el edificio totalmente acristalado del Palacio de Cristal, en el corazón del Parque del Retiro, donde se organizan estos intercambios; ahí también, fue donde el escultor catalán Jaume Plensa (Barcelona, 1955) creó en 2018, una monumental escultura hueca, titulada Invisibles, que retoma el tema de la transparencia. Así, analizaremos cómo el museo y el escultor abordan la cuestión del espacio en una dinámica que pretende reconsiderar el concepto de adentro-fuera, así como redefinir la percepción, dando de este modo al concepto de transparencia un contenido activo e interactivo y no un simple contenido de transparencia visual.
El museo inexistente. Panorama de proyectos inconclusos para un Museo Nacional amazónico en Perú
Authors: Herrera Miclea Morgana
Published: February 2025

The National Amazonian Museum is a project that has been planned in Peru since at least the 1940s and has never been carried out, despite the fact that it was foreseen in the plans for the important celebration of the Bicentennial of Independence in 2021. This article presents a first mapping of several failed projects of the Amazonian Museum as other manifestations of the neglect the Amazonian region suffers in Peru. It also shows the tensions between regional and national stakeholders around this museum, generator of conflicting and incomplete “museotopies”. The non-existent Peruvian Amazonian Museum is also analyzed as an absence that reveals all the complexities of the colonialist or utilitarian discourse projected on the Amazon.
The Possibilities of Using a Fire Extinguishing Substance Based on Water-Soluble Polymer for Extinguishing Solid Combustible Materials
Authors: Stylyk Igor , Kodrik Anatolii , Titenko Oleksandr , Zhartovskyi Sergii
Published: February 2025

У даному дослідженні представлені можливості використання вогнегасної речовини на основі водорозчинного полімеру для ліквідації пожеж на полігонах ТПВ та полігонах побутових відходів, пожежне навантаження яких утворюється за рахунок твердих горючих матеріалів. Теоретично та експериментально показано, що шляхом зміни концентрації гелеутворювальних добавок можна змінювати в'язкість, що безпосередньо впливає на швидкість випаровування та глибину проникнення вогнегасної речовини в осередок пожежі. Наведено результати експериментальних досліджень ефективності гелевих вогнегасників на основі полімеру ECOFLOC A-07.
Effect of Macro-Economic Factors on the Interest Rate Spread among Licensed Commercial Banks in Sri Lanka
Authors: Kumari D. A. T.
Published: February 2025

This research highlights the effect of macroeconomic determinants on the interest rate spread in licensed commercial banks in Sri Lanka. Based on existing literature, the study focuses on four key macroeconomic factors influencing interest rate spreads: Inflation rate, Bank rate, Exchange rate, and Treasury bill rate. The research utilizes secondary data obtained from the Central Bank of Sri Lanka, covering the period from January 2003 to December 2023, and analyzes it using a regression model. The E-Views statistical package was employed to process and analyze the data sourced from the Central Bank's annual reports and website for the specified period.Correlation analysis was employed to explore the relationships between the independent and dependent variables in the study. A regression model was used to assess the impact of macroeconomic factors on the interest rate spread. The results indicate that macroeconomic factors do influence the interest rate spread. Specifically, the study found that the exchange rate and treasury bill rate have a significant relationship with the interest rate spread, while the bank rate and inflation rate do not significantly affect the interest rate spread at a 0.5% significance level. Additionally, the bank rate, inflation rate, and treasury bill rates are positively correlated with the interest rate spread, whereas the exchange rate has a negative correlation. This study adds to the literature on factors that affect the efficiency of interest rate spreads, particularly highlighting the relationships among various aspects of interest rate spread. The findings could be valuable for financial managers, investors, financial management consultants, and other stakeholders.
The Impact of Socialization Agents on Adolescent Consumer Vulnerability: Moderating Role of Living Area (With Reference to Franchised Fast-Food Industry in Sri Lanka)
Authors: Nishadi G. P. K. , Warnakulasooriya B. N. F. , Chandralal K. P. L.
Published: February 2025

Adolescence is a critical period in the life cycle of a human being and the consumption of food in this stage is detrimental for growth and development. As per the existing findings, socialization agents play a role in impacting nutrition knowledge, preferences, and purchasing preferences associated with food. In comparison to other life stages, during adolescence, consumers are more interested in eating junk foods and most of the times they have no desire to eat homemade foods. Further, the current literature highlighted that increasing availability of fast-food has become a major reason for the consumption of fast-food among adolescents in Asian Countries. Within this backdrop, the present study strived to analyze the moderating role of Living Area on Socialization Agents and Adolescent Consumer Vulnerability, due to inadequacy of existing studies relevant to the field. Primary data were collected from 910 Adolescents studying in national government schools in Sri Lanka based on stratified random sampling method through a 69-item self-administered questionnaire. Results indicated that the five socialization agents; Peers, Parents, TV advertisements, Internet and Retailers positively influence on Adolescent Consumer Vulnerability in Sri Lankan franchised fast-food industry, proving the first five hypotheses. Further, hypotheses 6a was also accepted proving that Area of Living partially moderates the relationship between Socialization Agents and Adolescent Consumer Vulnerability.
LA RIFLESSIONE DELLE NAZIONI UNITE TRA PASSATO E FUTURO. SOSTENIBILITÀ AMBIENTALE, SOCIALE E FINANZIARIA: UNA SFIDA IMPOSSIBILE?
Authors: Missaglia Marco
Published: February 2025

In this essay, I will propose a reflection on the degree of compatibility among the environmental, social and financial sustainability. I will also show the key intellectual role that the United Nations played and are still playing in giving a, let us say, “slightly optimistic” answer to this key question: strengthening international cooperation is the only way to expand the otherwise extremely narrow space of compatibility among those three fundamental dimensions of sustainability.
CONSIDERAZIONI SULL’IMMAGINE DELLA SCIMMIA NEL MONDO ANTICO. IL MITO DEI CERCOPI FRA ICONOGRAFIA E FONTI LETTERARIE
Authors: Grazzini Stefano
Published: February 2025

The paper is an interpretive survey of the legend of the Cercopes, a myth widespread in archaic and classical times that revolves on a peculiar kind of divine punishment: the metamorphosis of human beings into apes. The juxtaposition of literary sources and iconographic sources makes it possibile to identify two main narrative strands: one, serious, is in fact part of the larger cycle of the labours of Heracles; the other, comic, may be regarded as a variant of the mythical theme featuring the hero himself and other satirical figures. In the comic variant a crucial role is played by the name Κέρκωψ, to be interpreted as “with the face in front of the tail”, that is to say, in front of Heracles’ posterior or genitals (as in the example of the two brothers who, after being captured, were placed in the upside-down position); another meaning of the name Κέρκωψ, related to the Cercopes’ impudence, can be traced back to a sexual metaphor still widespread to this day, the roots of which seem to lie in Mediterranean folklore. A connection can also be established between the comic variant and well-known scenes, common both in archaic and classical times, of attempted theft of Heracles’ weapons by satyrs and sileni. These scenes may be taken as narrative devices meant to support the metamorphosis into apes well attested for the Italiotic area; in particular, the ape’s traits are counterbalanced by the Heraclean attribute of μελάμπυγος.
Differentiating self-disclosure interventions from self-involving interventions based on the assessment of the short-term therapeutic effects: preliminary results
Authors: Monticelli Fabio , Massullo Chiara , Carcione Antonino , Tombolini Lucia , Guerra Flaminia , Liotti Marianna , Monticelli Cecilia , Gasperini Elena , Russo Marianna , Novaretto Samanta , La Vista Letizia , Mallozzi Paola , Imperatori Claudio , Del Brutto Chiara , Farina Benedetto
Published: February 2025

The therapist’s self-disclosure (TSD) interventions are considered beneficial and often used by psychotherapists. However, their use remains controversial for several reasons, including the use of broad definitions neglecting the distinction between the TSD and the therapist's self-involving (TSI) interventions. The TSD interventions involve the revelation of personal information to the patient, while the TSI implicates the direct expressions of the therapist’s reaction to the patient’s statements and behaviors within the session. To compare the immediate therapeutic effects of the TSD and TSI interventions, we conducted a study on 57 total interventions (i.e., 35 TSI and 22 TSD, respectively) performed during 17 psychotherapy sessions in a sample of 6 patients, evaluating the effects of each intervention (TSD or TSI) based on two parameters: patient’s cooperative attunement and patient’s metacognitive functioning. Results show that, compared to the TSD, the TSI interventions were followed by a higher cooperative attitude and metacognitive functioning of the patients. The difference in the short-term effects of these two interventions suggests the usefulness of considering TSD and TSI distinctly to evaluate their psychotherapeutic effectiveness.
Study on Associated Serious Underlying Systemic Conditions in Patients Presenting with Superficial Venous Thrombosis
Authors: Hebbani Nimeesh Seshadri , Desai Sanjay C , Gowda Suhas S , Ramswamy Chandrashekar Anagavalli
Published: February 2025

Introduction:

Superficial venous thrombosis (SVT) is a broad term used to describe the thrombotic occlusion of superficial vein(s). If associated with clinical findings of inflammation, the term superficial thrombophlebitis is used. It is an underreported and underestimated condition worldwide, as it has been assumed to be self-limiting and of little consequence. Thrombosis of superficial veins in the lower extremity is usually associated with varicose veins. However, a percentage of SVT not associated with varicose veins, may be an indicator of hypercoagulable states, malignancy, vasculitis, or other systemic diseases. The study would help in gathering significant data and establishing the pattern of associated serious underlying systemic conditions in the Indian population with SVT as the main clinical presentation.

Aims and Objectives:

The objectives of this study were to identify and determine the proportion of serious underlying systemic disorders associated with SVT.

Materials and Methods:

Retrospective single center record based study, covering 136 patients diagnosed with SVT, who came to the outpatient department or who got admitted, from June 2022 to December 2023. Data were collected and analyzed during the months of April–May 2024.

Results:

A total of 136 patients were included in the study, ranging in age from 24 to 72 years, with an overall mean age of 56 years (standard deviation ±14.2), with majority (80) of the patients being men. Most patients presented with isolated greater saphenous vein (GSV) thrombosis (92 patients), of which mid-GSV was the most commonly affected segment (48.9%). Sixty-one cases (44.8%) were associated with varicose veins. Twenty-nine patients (21.3%) presented with deep venous thrombosis (DVT) along with SVT. Twenty patients (14.7%) had underlying malignancies, of which gastrointestinal malignancy was the most common one (seen in nine patients). Fourteen patients (10.3%) were found to have hypercoagulable states. Four patients (2.9%) developed SVT following iatrogenic interventions. In four patients (2.9%), the cause could not be established. One case (0.7%) was noted postpercutaneous transluminal coronary angioplasty. Three cases (2.2%) developed following pregnancy.

Conclusion:

The study reveals a substantial proportion of patients with SVT have serious underlying systemic conditions such as malignancies, DVT, and hypercoagulable states. These findings challenge the traditional view of SVT as a benign and self-limiting condition, and emphasize the need of comprehensive diagnostic workup in these patients to identify and manage the underlying conditions, along with management of SVT.
Lateral Temporal Bone Resection in a Case of Squamous Cell Carcinoma Temporal Bone: Reconstruction and Surgical Outcomes
Authors: Dey Samyadipta , Chaudhary Pallavi , Guha Rajdeep
Published: February 2025

Squamous cell carcinoma (SCC) of the temporal bone is a rare malignancy of a complex, intricate anatomical system. These tumors are locally aggressive due to the multiple invasion routes within the region, involving anatomical foramina and neurovascular structures. The current treatment paradigm often involves lateral temporal bone resection to achieve tumor-free margins, typically combined with superficial or total parotidectomy. Early-stage disease may be managed with or without adjuvant radiotherapy, depending on factors such as tumor stage and histopathologic features. The rarity of SCC in this location makes optimal management strategies critical, with local control and esthetic outcomes being key goals of therapy. In this case report, we discuss the surgical management and reconstruction of a patient with high-risk SCC of the left temporal bone, now disease-free for 18 months. He shows satisfactory esthetic outcomes with no facial nerve palsy or locoregional recurrence.
Application of Nanotechnology in Cancer Therapy: Potential and Limitations
Authors: Mondal Sougata , Basu Debapriya , Maiti Bidisha , Ghosh Oyendrila , Ghosh Supratim
Published: February 2025

Nanotechnology is an emerging platform for increasing the selectivity and potency of different treatment modalities for progressive cancer therapy. Architectures of nanoscale are successively explored for delivery of water-insoluble drug molecules as well as malignant cell targeting, avoiding nonspecific toxicity. Nanotechnology can also help in the synergistic application of different therapeutics. Despite numerous advantages, the clinical application of nanoformulations is limited due to poor biodistribution, failure of enhanced permeability and retention-dependent targeting, and change in biophysical properties in the physiological environment. In this review, we summarized different promising properties of nanotechnology in combination with relevant challenges, with the help of corresponding literature and current status.
Magnetic Resonance Imaging Assessed Depth of Invasion Correlated with Histopathological Depth of Invasion in Patients with Carcinoma Tongue – A Tertiary Care Prospective Analysis
Authors: Sahu Sandeep , Chakrabarti Jayanta , Guha Rajdeep , Ray Amitabh , Singh Rohini , Paul Ratnadeep
Published: February 2025

Introduction:

Squamous cell carcinoma (SCC) represents the most common type of head-and-neck cancer comprising approximately 90% of all head-and-neck malignancies. More recently, oral SCC has climbed to the sixth most common global malignancy as of 2016. As per recent GLOBACAN 2018, 119992 new cases of oral cavity cancer are diagnosed every year, and around 72,000 die every year. Oral cancer is among the top three cancers in India.

Aims:

The aim of the study was to correlate and compare the radiological, and the pathological parameters in assessing the depth of invasion (DOI).

Methodology:

The present study was a prospective, nonrandomized, observational study. This study was conducted from January 2021 to March 2023 at Department of Chittaranjan National Cancer Institute, Kolkata. A total of 54 patients were included in this study.

Results:

We found that most of the patients had magnetic resonance imaging (MRI) (size) in T4aN2c (12 [22.2%]) and though it was statistically significant (P = 0.00424), (z = 2.8647). We examined that the majority of the patients had histopathology (HPE) (size) in pT1N0 (19 [35.2%]) but this was statistically significant (P < 0.00001), (z = 4.1332). In our study, the mean DOI MRI (mm) of patients was (15.8370 ± 7.8520), mean DOI HPE (mm) of patients was (12.9444 ± 6.5052), mean circumferential resection margin (other features on HPE) (mm) of patients was (7.2600 ± 3.6242), and mean positive nodal status (other features on HPE) of patients was (1.8519 ± 2.5134). The mean total nodal status (other features on HPE) of patients was (49.7222 ± 19.1079) and mean worst pattern of invasion (other features on HPE) of patients was (4.0000 ± 0.7268). We found that mean DOI MRI mm was significantly higher in 51–60 years of age (20.1308 ± 11.6743) compared to 31–40 years of age (17.1765 ± 5.6925), 41–50 years of age (14.9571 ± 2.8832), 71–80 years of age (13.2000 ± 6.2626), 61–70 years of age (12.0000 ± 3.4641), and ≤ 30 years of age (6.0000 ± 0.0000) (P = 0.0353).

Conclusion:

This study showed a strong correlation between MRI and HPE in DOI in all stages, especially when DOI was >5 mm, but for overall stage, MRI tended to significantly overestimate the disease burden.
An Algorithmic Approach to Defining Variants of Papillary Thyroid Carcinoma: Accuracy of Fine Needle Aspiration Cytology
Authors: Nigam Neha , Kumari Neha , Sahai Rishabh , Chaudhary Nandita , Mayilvaganan Sabaretnam , Prasad Pallavi , Mishra Prabhakar
Published: February 2025

Introduction:

Among thyroid malignancies, papillary thyroid carcinoma (PTC) is the most common, with the classical variant being the most common subtype. Some histological variants have aggressive behavior, advanced presentation stages, poor clinical outcomes, and may require additional therapy. Due to overlapping cytologic features and heterogeneity of lesions, the PTC classification is not adhered to in conventional reporting practice. This study aimed to classify the PTC cytology cases into a particular cytological variant by applying an algorithmic approach and correlating these variants with histology.

Materials and Methods:

An analysis of all histopathologically confirmed cases of PTC who had previously been diagnosed with fine needle aspiration cytology (FNAC) from January 2014 to December 2019 was conducted. FNAC samples of thyroid nodules were blindly reviewed and classified into different morphological variants using a stepwise algorithmic approach based on architectural, nuclear, and cytoplasmic features.

Results:

A review of 77 histologically proven cases of PTC variants or with a predominant area of variant histomorphology was done. One case was inadequate (TBSRTC I), nine cases were benign (TBSRTC II), two were follicular lesions of undetermined significance (TBSRTC III), and 65 cases were suspicious or definite for PTC (TBSRTC V/VI). Retrospective algorithmic cytopathological analysis of 65 cases that are suspicious or definite of PTC (TBSRTC V/VI) showed classical PTC (5), follicular variant-PTC (35), tall cell variant (20), diffuse sclerosing variant (1), warthin-like variant (2), and solid variant (2). Diagnostic accuracy of cytopathology in diagnosing the PTC variants when compared with histopathological diagnosis varied from 81.3% to 100% (mean 78.9%). Cluster analysis justified that our classification showed good agreement with the actual classification based on the cytopathological features identified by the cluster analysis.

Conclusion:

An awareness of cytomorphological features of aggressive variants may facilitate early and accurate diagnosis and appropriate clinical management with better patient outcomes. FNAC can subclassify PTC into different variants based on this algorithmic approach or aggressive and nonaggressive variants based on certain more frequently observed features.
Extraction of Rare Earth Elements (REEs) from coal ash of Thar, Pakistan by chemical leaching with Novel Deep Eutectic solvents
Authors: Mahmood Ahsan , Sharif Muhammad , Hussain Adil , Suleman Muhammad , Hayat Badar
Published: February 2025

The supply of rare earth elements is less and its demand is high so we need a secondary source to fulfill this demand. This research adopted coal ash as an alternative resource of rare earth elements. The mineral acids, ionic liquids, and organic acids were used for the extraction of rare earth elements (REEs) from Coal Ash (CA) which were corrosive, expensive, hazardous, and not friendly to the environment. Our approach was to find innovative reagents that were green to the environment and extract REEs from CA as a replacement for mineral acids, ionic liquids, and organic acids. The researchers synthesized a novel Deep Eutectic Solvent (Choline chloride & Humic acid) for the extraction of REEs. The study conducted experiments on the coal of Sindh Engro Thar Coal Mining Company (SECMC), Pakistan. Based on literature and ASTM standard D-2013 coal was crushed and ground to a size of -250 microns. The leaching experiments were designed with two different parameters (1-2 hours) time and temperature (60-90 Celsius) at a constant 500 revolutions per minute (rpm). After leaching, the filtrate was centrifuged at 4000 rpm for 10 minutes. Both the feed and leachate were analyzed using various techniques, X-Ray fluorescence (XRF), X-Ray Diffraction (XRD), Inductively coupled plasma mass spectrometry (ICP-MS), Fourier Transform Infrared Spectroscopy (FTIR), and Scanning Electronic Microscope (SEM).  In feed characterization, the XRF results showed that Calcium had the highest percentage which was 35.676%. Calcium sulfate, Diborane, and Magnesium oxide mineral phases were detected by XRD. ICPMS analysis showed the CA sample contained a total of 351.41 PPM of REEs. The concentration of heavy rare earth elements (HREEs) were 119.5 PPM, while the light rare earth elements (LREEs) were 231.91 PPM. Moreover, Lutetium had a PPM value of 96.56 and was the most prevalent REE. In FTIR spectroscopy C, C=O, C-H bond, C-O-C, N-O bond, and SiO functional groups were found. In SEM analysis, luminous and non-luminous features could be seen in the matrix which indicates the presence of minerals by raw CA sample while both luminous and non-luminous features were disseminated in CA dipped with DES sample. The leaching efficiency of the DES was increased by increasing the temperature and time. The highest leaching efficiency we achieved was at 90 degrees Celsius for 2 hours which was 90%, While, at 60 degrees Celsius for 1 hour the DES was at its lower peak and the efficiency was 62%. Our results showed that the DES was effective in extracting REEs from CA.
Sąd Najwyższy versus prawa podstawowe, czyli kilka uwag o skuteczności Karty praw podstawowych Unii Europejskiej w polskim porządku prawnym
Authors: Podolska Anna
Published: February 2025

December 1, 2024, marks the 15th anniversary since the Charter of Fundamental Rights of the European Union gained the effect equal to the Treaties. The Polish-British Protocol has also been in force for the same period. This is therefore a good time for some summaries or reflections. The subject of this article is an attempt to answer the question concerning the status of the Charter in the Polish legal order, primarily from the perspective of the jurisprudence of the Polish Supreme Court, as a court whose decisions have no legal remedy. The main subject of consideration, however, must be preceded by the limitations in the application of the Charter resulting from Article 51(1) of the Charter and the Polish-British Protocol.
The paper is divided into four chapters and a conclusion. The first chapter outlines the general context of the EU human rights protection system and the meaning of the Charter. This is followed by a discussion of concerns regarding the personal and material scope of the Charter. The next chapter analyses the case law of the Court of Justice of the European Union, the Polish Supreme Court, and the Polish Constitutional Tribunal on the understanding of the Polish-¬-British Protocol. The analysis carried out in the previous chapters highlights the context in which the Polish Supreme Court rules. Its activity focuses on the fourth chapter. The text concludes with a summary.
The text aims to provide an overview of the issues regarding the application of the Charter by the Polish Supreme Court. It mainly bases itself on case law to show the perspective of the courts, though it is not exhaustive and some issues, such as access to the preliminary ruling procedure, are only hinted at.
ANÁLISIS DEL SIGNIFICADO DE ALGUNOS TOPÓNIMOS DE LA LENGUA CULLI EN LA REGIÓN LA LIBERTAD
Authors: Carranza Rodríguez Aurelio Maximino
Published: February 2025

La toponimia, como subdisciplina de la onomástica, nos permite comprender la historia, la cultura y las lenguas de un territorio a través del significado de sus nombres de lugares. En este trabajo, se analiza el significado de algunos topónimos de la lengua culli en la región La Libertad, Perú, con el objetivo de preservar este valioso legado cultural.
Mediante una exhaustiva revisión bibliográfica y documental, entrevistas con hablantes nativos y expertos, y análisis etimológico, se desentrañaron los significados y orígenes de los topónimos culli. Los resultados revelaron una estrecha relación con la geografía, la cultura y la interacción lingüística de la región. Se identificaron términos relacionados con la geografía (subidas, bajadas, cerros, gradas), el agua (manantiales, pozos, recursos hídricos), las lenguas (interacción entre el culli y el quechua), el clima (llovizna, fenómenos meteorológicos), la vegetación (árboles, pastos, ramas) y la fauna (renacuajos).
Las conclusiones del estudio destacan la importancia de la toponimia culli como reflejo del entorno natural, el agua, la interacción lingüística, el clima, la vegetación y la fauna en las comunidades locales. Además, evidencian la presencia de morfemas culli en áreas históricamente asociadas con esta lengua, consolidando su valor como patrimonio lingüístico y cultural invaluable que debe ser preservado y valorado.
Se recomienda realizar investigaciones más profundas sobre la toponimia culli en la región La Libertad, incluyendo la recopilación de datos de campo y el análisis de topónimos en otras zonas. La preservación y valorización de este patrimonio cultural es crucial para la identidad de las comunidades locales.
APLIKASI MONITORING PEMBELAJARAN IQRO’ PADA SANTRI TK QUR’AN ASSYUKURIAH BERBASIS WEB DAN ANDROID
Authors: Solihati Tifani Intan , Febriani Reni , Kania Raden , Hidayanti Nur , Budiman Ramdani , Aziz Abdul
Published: February 2025

This study explores the design and development of applications to monitor student learning at TKQ Assyukuriyah. This research was conducted to increase the efficiency and effectiveness of the teaching and learning process, which was previously carried out conventionally and faced several obstacles, including loss or damage to books, and the ineffectiveness of providing learning progress reports from schools to parents. The formulation of the research problem is how the application provides access to questions for students and makes it easy to record reports on the results of evaluations of learning progress using the iqro' and juz amma methods with safe data storage and how parents obtain information on learning progress. This research aims to provide easy access to questions for students, teachers record the results of evaluations of learning progress in reading using the iqro and juz'amma methods with secure data storage and make it easier for parents to obtain information on learning progress. Using the waterfall method for software development. The results of this research show that this application has succeeded in simplifying the process of recording monitoring of students' learning progress by storing data safely, reducing the time and energy of teachers in preparing questions, and making it easier to provide information on learning progress to parents.
Keywords: Monitoring, Kindergarten-Qur'an, Learning, School, Waterfall.word
ESTIMASI LAJU PERTUMBUHAN PENDUDUK DI KABUPATEN JEPARA DENGAN PENDEKATAN REGRESI LINIER BERGANDA
Authors: Rachma Hetta , Nafisah Mutiatun , Hidayati Nurtriana
Published: February 2025

One of the main factors in planning the development of a region is the change in population. A rapid population growth rate can have adverse effects, such as poverty, unemployment, and a decrease in the quality of human resources. The purpose of this study is to predict the population growth rate in Jepara Regency by applying the multiple linear regression method, which can be used as a basis for the government in planning strategies to improve the economy, infrastructure, and other sectors, so that in the end it can have an impact on improving the welfare and quality of life of the community. The data used was obtained from BPS Jepara Regency for the period 2019-2023. Multiple linear regression analysis was applied as the method, with the number of males (X1) and females (X2) as independent variables, and the total population (Y) as the dependent variable. Based on the analysis, the predicted population in 2024 is 1,264,598 people, the same number as in 2023, indicating a stagnant growth condition. The results of this study provide important implications for government policy planning, especially in infrastructure development strategies, economic improvement, and human resource processing. The multiple linear regression method is effective in providing an accurate estimation picture, and can be the basis for future decision-making.
Objetos digitais de aprendizagem para o ensino da Química na perspectiva inclusiva: produções científicas (2019-2023)
Authors: Guedes Sumaya Ferreira , Leão Marcelo Franco
Published: February 2025

As Tecnologias Digitais (TD), quando direcionadas para o ensino, são consideradas como Objetos Digitais de Aprendizagem (ODA), e podem auxiliar os professores nas aulas, tornando-as mais interativas e atrativas aos estudantes. Nesse sentido, o presente estudo teve como objetivo realizar o mapeamento das produções científicas que abordam o desenvolvimento e/ou uso dos objetos digitais de aprendizagem para o ensino inclusivo de Química. Trata-se de uma pesquisa bibliográfica, de abordagem qualitativa, que utilizou como metodologia de pesquisa a Revisão Sistemática de Literatura (RSL). A busca foi realizada na plataforma de Periódicos Capes com descritores “Objetos digitais de aprendizagem”, nos anos de 2019 até 2023. Foram selecionados 14 artigos, sendo que nove envolviam os ODA com a Química e cinco que envolviam os ODA e a educação especial ou inclusiva. Infelizmente, não foi observado nenhum artigo que relacionasse o uso dos ODA para o ensino de Química na perspectiva inclusiva.
Budaya Organisasi, Berbagi Pengetahuan Dan Kinerja Organisasi
Authors: . Zulmaswan , . Nurliana , . Susandri
Published: February 2025

The research was conducted at all junior high schools in Kuantan Tengah subdistrict with the aim of testing the role of knowledge sharing in mediating the influence of organizational culture on organizational performance. The population of this study was 197 people. Based on this population size, in accordance with the Krejcie and Morgan (1970) table, the sample size for this study was 132 people. The sampling method used in this research is Systematic Random Sampling. All respondents will be used to obtain primary data related to the variables, which will be collected through a questionnaire with a 1-5 point Likert scale. All data obtained will be analyzed using Structural Equation Modeling (SEM) with the Smart PLS 3.0 analysis tool. This research found that organizational culture has a significant positive effect on organizational performance, organizational culture has a significant positive effect on the dissemination of knowledge, knowledge sharing has a significant positive effect on organizational performance, knowledge sharing mediates the influence of organizational culture on organizational performance.
Cybersilence: Analisis Resepsi Pengguna X Pada Verbal Cyberbullying
Authors: Salisah Fadiah Anggi , Rozi Fakhrur
Published: February 2025

Artikel ini menganalisis resepsi masyarakat terhadap komunikasi verbal yang berkaitan dengan fenomena cyberbullying di media sosial X. Urgensi penelitian ini muncul dari tingginya prevalensi cyberbullying yang berdampak negatif pada kesehatan mental pengguna media sosial. Masalah utama yang diangkat adalah bagaimana masyarakat merespons tindakan verbal cyberbullying dan dampaknya terhadap korban. Penelitian ini menggunakan metode kualitatif dengan pendekatan fenomenologi, memadukan data primer berupa cuitan pengguna X yang relevan dengan topik penelitian, serta data sekunder dari tinjauan pustaka. Teknik pengumpulan data melibatkan eksplorasi sistematis melalui Keyhole dan eksploding topics. Data dianalisis menggunakan analisis konten untuk mengidentifikasi pola dan tema resepsi terhadap pesan verbal terkait cyberbullying. Validitas data diuji melalui triangulasi teori dan sumber. Hasil penelitian menunjukkan bahwa respons terhadap cyberbullying sangat bervariasi. Sebagian besar korban melaporkan dampak negatif seperti stres, penurunan kepercayaan diri, dan rasa malu. Namun, terdapat individu yang menunjukkan resiliensi dan mampu mengatasi dampak negatif ini. Analisis juga mengungkapkan bahwa interaksi individu dengan media sosial dan lingkungan sosial mereka memengaruhi persepsi dan reaksi mereka terhadap cyberbullying. Diskusi mendalam menggunakan teori ekologi media dan resepsi Stuart Hall menyoroti bagaimana individu menafsirkan pesan dari pelaku, mulai dari penerimaan hegemonik hingga penolakan oposisi. Penelitian ini menegaskan pentingnya mengembangkan strategi intervensi berbasis empati, edukasi digital, dan dukungan emosional yang berpusat pada korban untuk menciptakan lingkungan daring yang lebih inklusif dan aman. Kesimpulannya, pemahaman komprehensif mengenai resepsi masyarakat terhadap cyberbullying dapat memberikan kontribusi signifikan dalam merancang kebijakan dan program pencegahan yang efektif.
YOUTUBE ПЛАТФОРМАСЫНДАҒЫ СҰХБАТ ЖАНРЫНЫҢЕРЕКШЕЛІГІ: ТИМУР БАЛЫМБЕТОВ ПЕН ЮРИЙ ДУДЬАРНАЛАРЫНДАҒЫ ШЫҒАРМАШЫЛЫҚ ІЗДЕНІС
Authors: Меруерт Ақық , Байымбетов Б
Published: February 2025

The article focuses on the place of the interview genre on theYouTube platform and why it is in high demand among the audience. As part ofthe study, a comparative analysis was made of the content of the channels«Vdud» and «Timur Balymbetov», which received high views on video hostingand attracted the attention of viewers with their professional interviews, andbased on the opinion of scientists, the features of the interview on YouTube weredetermined. In addition, the reasons for the departure of professional journaliststo the YouTube platform, the professional level of their products, and theproblem of creative search became the core of the research work. The influenceof visual elements on the transformation of the interview genre in terms ofcontent is scientifically comprehended.
МЕЖДУНАРОДНОЕ ОБРАЗОВАНИЕ И ВКЛАД В РАЗВИТИЕСВОЕЙ СТРАНЫ: ОПЫТ ВЫПУСКНИКОВ ГОСУДАРСТВЕННЫХ СТИПЕНДИАЛЬНЫХ ПРОГРАММ КАЗАХСТАНА
Authors: Джонбекова Д , Серкова Е , Керимкулова C , Джумакулов З , Спаркс Дж , Руби А
Published: February 2025

This study analyzes Kazakhstan’s two educational scholarshipprograms designed for pursuing international education and graduates’contribution to national development. Our data suggests that Bolashak andNazarbayev University scholarship programs play an important role indeveloping local talent. Graduates of these scholarship programs are involved inimproving systems and practices in their workplaces, thereby contributing towider positive social and economic changes in the country. On the other hand,limited employment opportunities in some sectors of economy, low salaries andnegative bureaucratic culture limit graduates’ contribution to the common good.We believe that graduates’ inability to use the acquired knowledge and skills isassociated with low rates of economic development and its failure to keep upwith the development of human capital. Our findings highlight the criticalimportance of developing the economy in tandem with human capitaldevelopment to maximize the benefits of scholarship programs
СOVID-19 ПАНДЕМИЯСЫ КЕЗІНДЕГІ БҰҚАРАЛЫҚ АҚПАРАТ ҚҰРАЛДАРЫНЫҢ РӨЛІ: «ЕГЕМЕН ҚАЗАҚСТАН» МЕН«АЗАТТЫҚ РАДИОСЫ» МЫСАЛЫНДА
Authors: Долаева Камила , Кәпқызы Е
Published: February 2025

The COVID-19 pandemic, having made adjustments to theinformation agenda, has become the main topic of the media market. The role ofjournalists, as well as the activities of the media to disseminate information,increased many times during this period. In 2020-2021, the world media saw asignificant increase in the number of materials of various genres and forms thatraise this topic. Kazakhstan did not remain aloof from this process. In this regard,the main purpose of the article was to study the activities of Kazakhstanijournalism during COVID-19.“Egemen Kazakhstan” and “Radio Azattyk” were taken as the object of thestudy, the features of the two portals in the presentation of this topic wereidentified, an appropriate content analysis was carried out, and a scientificallybased conclusion was made about the weaknesses and rational aspects of themedia of Kazakhstan during the pandemic.
ТЕЛЕЖАРНАМАДАҒЫ ГЕНДЕРЛІК СТЕРЕОТИПТЕР : ҚАЗАҚСТАНДЫҚ ТӘЖІРИБЕ
Authors: Есенгельдиева Шұғыла
Published: February 2025

The article deals with the use of gender stereotypes in televisionadvertising and their impact on the audience. The types of gender stereotypesthat are often used in advertising production are identified, their advantages anddisadvantages are highlighted. For this, the experience of a number of countriesin the use of gender stereotypes is taken into account and the image of a womanis discussed there. In addition, the use of stereotypes as a means of propaganda,their impact on the mass consciousness and their dangers have become the mainsubject of research.Today, the attitude of the audience towards advertising has changed. Ifearlier consumers accepted advertising stereotypes without objection, now suchan attitude is alien to them. This is why marketers prioritize the notion that “badcommunication is more likely to work against a brand.”The scientific work determined that the new stereotypical processes inadvertising reflect deep internal changes in the system of values that underlieculture and society.
The Viability of a Scientific Philosophy: Proving that Computers are Human Creations without the Ability to Think
Authors:   Candidate of Chemical Sciences, Republic of Kazakhstan, Karabalayevich Altaev Namaz
Published: February 2025

In 1950, an article was published, which contained the conclusions of the Turing test [1]. Then, representatives of the logicism doctrine made the following
conclusion. That in principle it is possible to create an Artificial Intelligence (AI) that can think like a person. With another, representatives of the psychology
doctrine concluded that this is impossible. For example, H. Dreyfus claimed that it is impossible to achieve from an AI program efficiency comparable
to a person [2]. D. Searle argued that a computer is just a symbol-searching device using a set of syntactic rules. What it lacks is the ability of biological
intelligence to interpret semantics. Biologically, the roots of semantics of meaning remain a mystery [3]. In this article, developing the ideas set out in article,
an attempt is made to prove the following [4]. Computers created by people can never acquire the ability to think.