bluuebunny/crossref_metadata_2025 huggingface dataset:
RATIONAITY AND INTERVENTION EFFICIENCY OF CLINICAL PHARMACIST IN USAGE PAINKILLERS AFTER OPERATION
Authors: Phuong Chi Bui Dang , Tri Bui Dang Minh , Hiep Bui Tung , Anh Tran Nhat
Published: July 2021

Objectives: To evaluate the rationality and effectiveness of clinical pharmacist’s intervention in the use of painkillers for post-operative pain treatment at the General Surgery Department of Cai Nuoc General Hospital. Objects and methods: Cross-sectional descriptive study on 172 patients (patients) undergoing surgery at General Surgery Department, Cai Nuoc General Hospital. Results: There were 38.95% of patients studied with adverse effects when using painkillers. The average duration of painkiller use after surgery was 5.6 ± 4.0 days. The differences in the mean time to take the drug between the 2 groups were statistically significant. VAS pain scores of the study samples tended to decrease gradually over 1, 3, 5, 7 days after surgery. On 2 research groups, in general, the average VAS score after 1 day surgery was 4.2 ± 1.9 points and after 7 days was 1.1 ± 0.8 points. Increase the reasonable rate in choosing drugs group 2 with reasonable rate was had a reasonable rate of 68.18%, much higher than group 1 with 46.43%. Conclusion: The incidence of adverse effects was low. The differences in the mean time to take the drug 70.45%, much higher than group 1 with 42.86%; drug dose, group 2 had reasonable rate was 82.95%, much higher than group 1 with 55.95%; the rationality of drug use, group 2 between the 2 groups were statistically significant. VAS pain scores of the study samples tended to decrease gradually over 1, 3, 5, 7 days after surgery. Increase the rationality of drug selection, drug dosage, and general rationality of post-operative pain treatment.
SITUATION OF DRUGS FOR TREATMENT INTESTINAL INFECTION
Authors: Khanh Lam Hoang , Phuc Nguyen Huu , Hiep Bui Tung , Tri Bui Dang Minh
Published: July 2021

Objective: To survey the use of drugs to treat intestinal infection at Can Tho Children’s Hospital. Objects and methods: Cross-sectional retrospective descriptive study on 400 medical records of pediatric patients diagnosed with intestinal infection in Can Tho City Children’s Hospital in 2019. Result: There were 353 pediatric patients using rehydration and electrolytes measeurement, ORS with the highest frequency was 38.66%. The antibiotic with the highest frequency of use was the beta-lactam 3rd group. In which, Cefotaxim had the most use frequency. Single regimen of cefotaxim used the most with a frequency of 70.06%. Meanwhile, the antibiotic regimen cefotaxime combined with tobramycin was the highest in the combined regimen with 57.14%. Up to 70 cases changed the regimen due to ineffective results and 22 cases changed the regimen due to its effectiveness, reducing the amount of antibiotics. The first regimen with the highest frequency of change was the cefotaxim regimen with 33 cases. The 2nd regimens changed with the highest frequency were cefotaxim regimen and regimen of cefotaxim combined with tobramycin with 5 cases. The third change of regimen was mostly from combination antibiotic regimen to single regimen. Conclusion: Rehydration and electrolyte measures were mainly ORS. Antibiotics used mainly in the beta-lactam 3rd group, Cefotaxim had the highest frequency of use. Cefotaxim was used the most frequency in a single regimen. The antibiotic combined regimen between cefotaxime and tobramycin was the highest use in all combined regimens. Changing treatment regimen was mainly due to the ineffective effect.
RESULTS OF THE EDUCATION AND COMMUNICATION ABOUT HYPERTENSION PREVENTION AMONG CHAM PEOPLE IN PHAN THANH COMMUNE, BAC BINH DISTRICT, BINH THUAN PROVINCE
Authors: Tap Nguyen Van , Binh Nguyen Thanh , Huy Nguyen Ngoc , Hau Tran Phuc , Ngoc Le Thi
Published: July 2021

Mục tiêu nhằm đánh giá hiệu quả sau can thiệp về kiến thức phòng chống tăng huyết áp ở đồng bàoChăm. Thiết kế nghiên cứu can thiệp cộng đồng có đối chứng được tiến hành trên hành trên 400 đồngbào Chăm trước và sau can thiệp ở mỗi nhóm từ 18 tuổi trở lên từ tháng 01/2018 đến tháng 12/2018tại xã Phan Thanh, huyện Bắc Bình (xã can thiệp) và xã Phú Lạc, huyện Tuy Phong (xã đối chứng).Kết quả cho thấy tỷ lệ đồng bào Chăm có kiến thức đúng về chỉ số tăng huyết áp (tăng từ 56,5% lên68,8%), triệu chứng bệnh (tăng từ 60,3% lên 71,3%), biến chứng bệnh (tăng từ 63,3% lên 75,5%),yếu tố nguy cơ (tăng từ 42,5% lên 57,8%), biện pháp điều trị (tăng từ 44,0% lên 59,0%), biện phápphòng bệnh (tăng từ 49,7% lên 61,0%), kiến thức chung đúng (tăng từ 29,7% lên 47,3%) ở xã canthiệp vào thời điểm sau can thiệp (SCT) đều cao hơn so với trước can thiệp (TCT) (p<0,05). Phântích khác biệt kép (DID), cải thiện kiến thức phòng chống tăng huyết áp của đồng bào Chăm có liênquan với nhóm tuổi. Kiến thức về phòng chống tăng huyết áp của đồng bào Chăm còn hạn chế tạithời điểm TCT nhưng đã được cải thiện đáng kể SCT. Kết quả nghiên cứu cho thấy vai trò, tầm quantrọng và sự cần thiết của việc thường xuyên giáo dục sức khỏe nâng cao kiến thức, thực hành vềphòng chống tăng huyết áp cho đồng bào Chăm.
CAPACITY OF COMMUNE HEALTH STATIONS TO PROVIDE HEALTH CARE SERVICES FOR THE ELDERLY
Authors: Nga Nguyen Thi Thuy , Man Van Cong
Published: July 2021

Tuổi thọ tăng là một trong những thành tựu to lớn về phát triển kinh tế - xã hội nói chung và chămsóc sức khỏe nói riêng. Tuy nhiên, già hóa dân số diễn ra với tốc độ nhanh đặt ra thách thức lớn hệthống chăm sóc sức khỏe (CSSK) người cao tuổi (NCT), đặc biệt tuyến y tế cơ sở như các Trạm Ytế. Nghiên cứu này nhằm mô tả sự sẵn sàng cung cấp dịch vụ chăm sóc sức khoẻ người cao tuổi tạitrạm y tế.Nghiên cứu kết hợp giữa định lượng và định tính tại 15 trạm y tế và Trung tâm y tế huyện Cần Đước,tỉnh Long An, Việt Nam.Kết quả nghiên cứu cho thấy các trạm y tế chưa sẵn sàng cung cấp dịch vụ CSSK người cao tuổi dothiếu nhân lực y tế; chưa đảm bảo về thuốc, trang thiết bị (TTB) để khám sàng lọc, chẩn đoán và điềutrị các bệnh bệnh mạn tính thường gặp ở người cao tuổi (NCT) như: Tăng huyết áp (THA), Đái tháođường (ĐTĐ), Hen phế quả/Phổi tắc nghẽn mãn tính (HPQ/COPD) và ung thư.
SOME FACTORS RELATED TO KNOWLEDGE AND PRACTICE OF USING ANTIBIOTIC DRUGS FOR CHILDREN UNDER 5 YEARS OLD CHILDREN IN TWO COMMUNITIES, KIEN XUONG DISTRICT, THAI BINH PROVINCE, 2020
Authors: Ai Nguyen Thi , My Nguyen Ha , Dieu Bui Thi Huyen , Binh Bui Thi
Published: July 2021

Objective: To identify some related factors of caregiver use of antibiotics in under 5 years old in twocommunes, Kien Xuong district, Thai Binh province by 2020.Study object: caregivers in two communes of Kien Xuong district, Thai BinhResearch method: Epidemiological method described through cross-sectional investigation withanalysis.Research results: There is a relationship between educational attainment, number of children,economic conditions and age with knowledge of antibiotic use: the proportion of subjects withhigh school knowledge has achieved Antibiotic use is 1.8 times more likely than the group witheducation from high school or less, 95% CI (1.1-2.9). Regarding practice, there is a relationshipbetween knowledge, age of research subjects, parents of children and practice of using antibiotics.the rate of subjects with knowledge achieved with practice is 3.9 times higher than the group withsuccessful practice with unsatisfactory knowledge; The percentage of study subjects who are parentsof children having practice of antibiotic drugs is likely to be 2.5 times higher than that of the child’sgrandparents.
CONCENTRATION OF BORATE SALT IN READY-TO-EAT FOODS AT CHUA HANG MARKET IN THAI NGUYEN CITY IN 2020
Authors: Khanh Dao Duy , Duong Truong Thi Thuy
Published: July 2021

With the objective description of the actual use borate salt in some processed foods available in the market Chua Hang, Thai Nguyen city in 2020, the study was conducted according to the descriptivemethod, designed to cross- sectional on 60 samples of pre-processed food (pork rolls, pork rolls, vermicelli, meat pie, cast wheels) at the study site. Technical was conducted qualitative and semiquantitative borate salt by Decision 3390/2000/Decision-Minister of Health: “technical conventional regulations qualitative and semi-quantitative borate salt or boric acid” by the Minister of Health. The research results showed that: The number of samples tested positive for borate salt in Chua Hang market quite high, accounting for 80% of the whole food sample. The content of borax at: ≤ 0.5 mg%, accounting for a high percentage (73.3%), but still 6.7% at the level of > 0.5 - 1 mg%. The average content of borax in food samples at Chua Hang market: pork rolls (0.24 ± 0.31), pork rolls (0.27 ± 0.38), vermicelli (0.09 ± 0.14) , meat pie (0.05 ± 0.06), cast cake (0.03 ± 0.04).
TRAINING NEEDS ON HEALTH COMMUNICATION AND EDUCATION ABOUT DIABETES AMONG VILLAGE HEALTH WORKERS IN VU THU DISTRICT, THAI BINH PROVINCE IN 2020
Authors: My Nguyen Ha , Nga Phan Thu , Ai Nguyen Thi , Dieu Bui Thi Huyen , Dat Pham Tuan
Published: July 2021

Objective: Identify training needs on health communication and education about diabetes among village health workers in Vu Thu district, Thai Binh province in 2020.Subjects: Village Health Worker and Head of Commune Health Station in the communes of Vu Thu district, Thai Binh province.Method: the epidemiological method described through the cross-sectional investigation, combine quantitative research and qualitative research.Results: 70.2% of village health workers had participated in training courses on communication skills - health education; The highest proportion of respondents saying that the training period was enough (76.8%), 95.6% of the respondents think that the content of each training course was appropriate for them, and 62.3% evaluated organizational form of the training class to attract students; 50.4% ofvillage health workers needed to be trained in health communication skills, 49.5% of village health workers needed to be trained in health counseling skills, 26.2% hoped to train communication skillsthrough loudspeakers, radio; The most difficulty of village health workers when participating in training / training was due to a matter of time (41.1%).
PATIENT'S SATISFACTION COME FOR EXAMINATION AND REATMENT AT MEDICAL FACILITIES IN VIETNAM. SYSTEM OVERVIEW STUDY, PERIOD 2010-2020
Authors: Ly Tran Thi , Nhu Dang Duc , Thang Tran Quoc , Luong Duong Duy
Published: July 2021

Background: Patient’s satisfaction is a measure of the health facilities’ reputation and quality of health services. Therefore, determining the satisfaction of the patients in the current context is extremely necessary and meaningful. It provides the evidence for quality improvement of health services.Objective: A systematic review to review research findings on the the satisfaction level and relevant factors, analysis of strengths, weaknesses and deficiencies that need to be supplemented by further studies.Methods: Systematic review.Results: Searched and analyzed 32 national studies related to patient satisfaction. The results show that studies were carried out on many different subjects and locations with different levels of satisfactionConclusion: The satisfaction level of patients is quite high (satisfaction rate is over 70%, average score is over 3.5). Factors with high satisfaction rates include: Information transparency; Behavioralattitude and professional capacity of medical staff. Factors with not high satisfaction rates include: Infrastructure; Accessibility; Service results. Relevant factors: Patient’s satisfaction is not / verylittle related to demographic factors such as: Age, occupation, education level, medical examination target (with health insurance / no health insurance). Factors related to the patient’s satisfaction levelinclude: waiting
TO EVALUATE IVF OUTCOME BETWEEN FLARE-UP VERSUS ANTAGONIST AMONG POOR RESPONDERS’ PROGNOSIS PATIENTS AND RELATED FACTORS AT NATIONAL CENTER FOR ASSISTED REPRODUCTIVE TECHNOLOGY
Authors: Tho Nguyen Anh , Anh Ngo Toan , Hoi Nguyen Xuan , Tien Nguyen Viet
Published: July 2021

Objectives: To assess the outcome of Flare-up versus Antagonist protocol and to determine factors related to poor responders.Methodology: this is a random control trial among 834 patients who were predicted to ovarian poor response from 2014 to 2018.Results: The rate of biochemical pregnancy was 4.5% with Flare-up versus 8,1% with Antagonist (p<0.05). The rate of fertilization, implantation and clinical pregnancy were not significant differentbetween the 2 protocols. Age and number of AFC were significant factors to predict poor ovarian response. However, with Flare-up, there were 2 more factors could be used for the purpose whichwas basal FSH and E2 day 7.Conclusion: The outcome of treatment between Flare-up and Antagonist among predicted poor ovarian response was comparable. Age and AFC were valuable factors in prediction of poor ovarianresponse.
EFFECT OF EMULSION SBR PREPARED BY ASYMMETRIC REVERSIBLE ADDITION-FRAGMENTATION TRANSFER AGENT ON PROPERTIES OF SILICA-FILLED COMPOUNDS
Authors: Hwang Kiwon , Song Sanghoon , Kang Yu yeong , Suh JaeKon , Jeon Heung Bae , Kwag GwangHoon , Paik Hyun-Jong , Kim Wonho
Published: July 2021

The development of ultra-high-performance tires that satisfy fuel efficiency, traction, handling performance, and abrasion resistance has gained significant importance in the tire industry. Solution SBR has been used as a raw material, owing to its useful characteristics (e.g., narrow dispersity controllable microstructure and chain-end functionalization). In a recent improvement, emulsion SBR (ESBR), a high-molecular-weight compound with narrow dispersity, has been reported for application in the tire tread compounds. In particular, S,S-dibenzyl trithiocarbonate (DBTC) reversible addition-fragmentation transfer (RAFT) ESBR has exhibited excellent abrasion resistance and fuel efficiency in unfilled and carbon black–filled vulcanizates. However, owing to the symmetrical structure of DBTC RAFT ESBR, the polymer chain was shortened by the reaction of a silane coupling agent with trithiocarbonate, leading to poor abrasion resistance and fuel efficiency in the case of silica-filled vulcanizates. In this study, benzyl (4-methoxyphenyl) trithiocarbonate (BMPTC), an asymmetric RAFT agent that promotes unilateral polymer growth, was synthesized and used in the polymerization of BMPTC RAFT ESBR. Chain cleavage was not observed. Upon application to silica-filled vulcanizates, BMPTC RAFT ESBR exhibited improved abrasion resistance (by 9%), improved fuel efficiency (by 20%), and improved wet traction performance (by 10%) compared with the DBTC RAFT ESBR.
Green synthesis, Characterization and In vitro Biological Studies of Quercetin complexes with Zn (II) Acetate and N^N Moiety
Authors: Srivastava Tanu , Mishra S. K. , Tiwari O. P. , Nath Tiwari Kavindra , Kumar Pradeep , Kumar Jitendra , Kumar Singh Amit , Singh Angaraj , Dwivedi Ashutosh
Published: July 2021

Green synthesis of two coordination complexes of zinc acetate with N^N moiety on quercetin, which is a flavonoid is carried out. The complexes were obtained in high yields (> 97%) by grinding methods without the involvement of any solvent. Neither catalyst nor any additives were needed to perform the reactions. It was characterized by FT-IR, UV-Vis, NMR, HRMS, and elemental analysis. Antioxidant activity was done through the DPPH method which was compared with ascorbic acid and ligand (Quercetin). The study reveals that Complex 1 (IC50 163.093µg/ml) has significant free radical scavenging activity as compared to complex 2 (IC50 258.683µg/ml). Biological activity was performed against microbes (E. coli and S. aureus). MIC value of complex 1 (15.50µg/ml E. coli, 7.18µg/ml S. aureus) was found more significant as compared to complex 2 (22.51µg/ml E. coli, 18.62µg/ml S. aureus) and quercetin.
A Study to find the effectiveness of Scapular Strengthening Exercise in patients with Cervical Dysfunction
Authors: K Kotteeswaran. , Kumar Nayak Chiranjibi
Published: July 2021

Background: Cervical spine dysfunction is a cause of neck pain. The cause for it is believed to be a disorder (most likely malalignment) of the pain-sensitive facet joints (which may also be due to disc disruption). Dysfunction can also cause secondary muscle spasm, which can may lead to more pain and stiffness. Objective: To find the effectiveness of SNAGs and scapular strengthening exercises in the patients with chronic cervical dysfunction. To find the Neck disability index (NDI) score difference between the functional activities of experimental group and conventional treatment group. Methodology: According to inclusion and exclusion criteria a prior to the study, the principal researcher explained the procedures to all the subjects and inform consent obtained, 30 subjects taken through Random block design and numbering was done for all the subjects. All the odd numbers in one group and all the even numbers in another group are allocated by random table where each group had 15 subjects. The collected data was tabulated and analyzed using descriptive and inferential statistics. To all parameters mean and standard deviation (SD) were used. Paired t-test was used to analyze significant changes between pre-test and post-test measurements. Unpaired t-test was used to analyze significant changes between two groups. Result: rom statistical analysis made with the quantitative data revealed statistically significant difference between the Group A and Group B, and also within the group. The Posttest mean value of Neck Disability Index (NDI) in group A is 12.00 and in group B is 13.80. This shows that Neck Disability Index (NDI) in Group B disability value were comparatively more than Group A disability value, P<0.0001. Conclusion: This study shows better improvement in reducing cervical spine dysfunction (neck pain) by scapular strengthening exercise than resisted neck isometrics. Both the techniques can be used in clinical practice.
Optimization and Evaluation of Orodispersible Solid Dispersion Tablet of Ketotifen Fumarate
Authors: Salman Zeina D
Published: July 2021

The present study was aimed to integrate the developed and optimized ketotifen fumarate dispersion into Orodispersible tablets formulations, to enhance the dissolution rate and bioavailability aspects of the drug. Ketotifen fumarate solid dispersion was prepared using different concentrations of poloxamer 407via solvent evaporation and fusion method. Solubility study, x-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and other investigations were done. Ten formulations of the optimum dispersed ketotifen fumarate Orodispersible tablets were prepared with various superdisintegrants, the results of in vitro - in vivo tests revealed that, the dispersion of the drug in the polymer considerably enhanced the solubility, the batch (Fsd 3) prepared by fusion method showed increased the solubility as ~2-fold compared with a pure drug. FTIR spectra, SEM and XRD data, showed amorphrization of ketotifen fumarate, which explains the better dissolution rate of the drug from its solid dispersions. Formulation F1 containing 15%w/w of crospovidone was showed in vitro- in vivo disintegration time (17 sec., 15 sec. respectively) and percent of drug dissolved in 2 min. was 90.04%, proved to be the optimum formulation, which is required for obtaining rapidly disintegrating tablets. The solubility of the drug had increased, and the resultant orodispersible tablets can be considered as a promising dosage form to achieve better patient compliance.
In-vitro Anti-inflammatory activity of Total Phenolic content of some fruit juices in Syria
Authors: Nezam Akram , Al Diab Dima , Hasan Nouma
Published: July 2021

Fruit juices are considered as an important source of phenolic compounds. Black mulberry, pomegranate and orange juices were selected to assess their anti-inflammatory activity. Total phenolic content was determined using Folin-Ciocalteu colorimetric method. The anti-inflammatory activity was evaluated using RBC membrane stabilization method. Ibuprofen was used as a standard drug. Total phenolic content of black mulberry juice, pomegranate juice and orange juice was 3.02 gGAE/l, 1.83 gGAE/l and 0.76 gGAE/l and the percentage inhibition of RBC haemolysis varied between (27.41-43.19%), (24.06-39.06%) and (10.12-22.54%), respectively. Black mulberry juice revealed the highest anti-inflammatory activity among the studied juices. This finding might be attributed to the high phenolic content of this juice compared to others.
Phytochemical Assessment of Mimusops elengi Linn. Unripe fruits Methanol extracts using Modern Analytical Technique
Authors: Mishra Bishwanath , Dash Sujit , Chandra Sahoo Amaresh , Kumar Sahoo Prabhat , Tabasum Sazia
Published: July 2021

Mimusops elengi Linn. is a plant with high medicinal and commercial value. Although several secondary metabolites have been reported from different species of this plant, there has been not much information available on the complete profile of phytochemical constituents in Mimusops elengi Linn. The HPTLC fingerprinting of methanol extract showed 6 peaks having maximum Rf values 0.10, 0.27, 0.34, 0.51, 0.72, and 0.80 at 254nm. The same extract showed 3 peaks having maximum Rf value 0.25, 0.29 and 0.49 at 366 nm. This study applies Gas chromatography-Mass spectrometry technique to determine the possible chemical components in the methanol extract of Mimusops elengi Linn. Unripened fruits reports for the first time most extensive profile of the plant. The determination and identification of bioactive chemical compounds is established and based on the peak area, retention time molecular weight, and molecular formula. GC-MS analysis of Mimusops elengi Linn. revealed the existence of the 2,2’ Methylenebis [3,4,6-trichloroanisole] which was found to be major component followed by Z-1,9-Hexadecadiene, Cyclopentaneundecanoic-acid, 4-Methyloctanoic acid and E-10-Dodecen-1-ol propionate. The results obtained may be helpful to the further study of pharmacological action for their promising utilization as therapeutic agents.
Hepatoproective Nature of Aerial parts of Caesalpinia pulcherrima in STZ Induced Diabetic Rat Model
Authors: Pooja Pooja , Avijit Mazumder , Das Soumya
Published: July 2021

Diabetes is a chronic disease which characterized by hyperglycemia (elevated or abnormally high blood sugar levels) and other metabolic disturbances, including metabolism of lipids and haemostasis. Caesalpinia pulcherrima has previously showed strong anti-diabetic and hepatoprotective potential. The present research work was to investigate the anti-diabetic activity and hepatoprotective activity Caesalpinia pulcherrima in streptozotocin-induced (STZ) diabetic rats. The dose-dependent effects of 45days oral treatment with methanol extract of plant (200 and 300mg/kg) of CPAE on body weight, blood glucose level, total protein, albumin, liver marker enzymes and carbohydrate metabolizing enzymes were evaluated in STZ-induced diabetic rats. Oral administration methanolic extract of Caesalpinia pulcherrima of showed significant restoration of the body weight and decrease in the blood glucose level, liver marker enzymes (ALT, AST ALP) and carbohydrate metabolizing enzymes were observed in diabetic rats. These results suggest that fruit extract of Caesalpinia pulcherrima has valuable anti-diabetic activity in STZ-induced diabetic rats which is comparable to the standard drug metformin and hence might be of use in the management of diabetes.
Naringenin attenuates cerebral Ischemia-Reperfusion injury through Inhibiting oxidative stress and Inflammation in Diabetic Rats
Authors: Prabhakar Orsu
Published: July 2021

Aim: Ischemic stroke is one of the important complications of diabetes. Diabetes exacerbate cerebral injury after ischemia and reperfusion. This study was designed to investigate whether the naringenin has a cerebroprotective action against the ischemic reperfusion injury via anti-oxidant and anti-inflammatory mechanisms in diabetic rats. Diabetes was induced by Streptozocine (50mg/kg) intraperitoneal injection at once. Medial carotid artery occlusion (30 min) and reperfusion (3 hr) was employed to induce cerebral infarction in diabetic rats. The animals were divided in to groups as: normal, sham, ischemia-reperfusion and naringenin treated (50, 100, 150 and 200mg/kg). These were used for evaluation of percentage of cerebral infarction. Further, 200mg/kg dose was selected for the estimation of inflammatory biomarkers such as Tumor necrosis factor-α, Interlukin-6, Interlukin-10 and oxidative stress biomarkers such as malondialdehyde, superoxide dismutase, and catalase were estimated and histopathological changes were studied. Dose dependent reduction in percentage of cerebral infarction was observed in narigenin treated groups. With Naringenin 200mg/kg dose, inflammatory and oxidative stress markers like Tumor necrosis factor-α, Interlukin-6, myeloperoxidase and malondialdehyde levels were distinctively reduced and there was a remarkable increased levels of anti-inflammatory and anti-oxidant markers like Interlukin-10, catalase, and superoxide dismutase. Conclusion: Collectively, these findings demonstrate that the mechanism (s) responsible for a cerebroprotective effect of naringenin against the ischemic reperfusion injury in the diabetic rats involves anti-oxidant and anti-inflammatory actions.
Repurposing statins as a potential ligand for estrogen receptor alpha via molecular docking
Authors: Alisha Khandelwal , Tripti Sharma
Published: July 2021

Computational drug repurposing is the strategy for drug development which remarkably reduces the cost and development time. Research suggests that breast cancer development in women have been associated with cholesterol and its transporters. Cholesterol lowering drugs can be repurposed as potential therapeutic agents to prevent high cholesterol in estrogen receptor positive- breast cancer. The objective of this study was to carryout in-silico molecular docking of HMG-CoA reductase inhibitors (statins) with estrogen α receptor (3ERT) to repurpose the statins as breast cancer inhibitors. Molecular docking studies were performed to explore the mechanism of interactions between the statins and human estrogen α receptor. Docking results revealed that statins bind to the hydrophobic pocket of the estrogen α receptor with high binding affinity. The docking scores were compared with the standard drug 4- hydroxy tamoxifen. The study helped to compare the interactions amongst different statins with the receptor and the energy values produced were ranging from -8.5 to -5.5 kcal/mol. Molinspiration web servers was used to calculate the physiochemical properties and ADMET of the statins. Simvastatin showed better interaction amongst the docked statins with best protein ligand interactions, it was found to exhibit higher docking score of -8.5 kcal/mol. Therefore, we conclude that statins can be employed as an alternative drug for treatment of breast cancer.
Morphological and Morphometric study of Jugular Foramen in human dry skull of Eastern Indian origin: An Anatomical Investigation
Authors: Baisakh Pratima , Nayak Lopamudra , Pradhan Sujita , Ranjan Das Saurjya , Kumar Panda Sitansu
Published: July 2021

Background: Jugular foramen (JF) is one of the complex foramen present in base of skull. It varies in shape and size from side to side in same cranium, in different cranium and in different races. It is associated with many diseases of posterior cranial fossa and many skull base surgeries are being carried out by drilling the skull bone around JF for better exposure. Aim and objectives: The present study aims to carry out the morphological and morphometric analysis of jugular foramen of skulls of eastern Indian origin. Materials and Methods: The study was carried out on 100 JF of 50 dried human skulls. Anteroposterior(width), medio-lateral diameter(length) of JF, width and depth of the jugular fossa were measured. Mean and standard deviation of different measurements of left and right side were statistically analysed by student’s t-test. Presence of dome and septum were also studied. Results: The mean of all the measurements are more on right side than left side but it is statistically insignificant (p>0.05). Bony septum was found in 76% cases on left side and 60% on right side. Complete septation wasn’t found in our study. Domed roof was present in 66% cases on right side as compared to 52% on left side. Conclusion: Shape and size of JF may vary due to different size of internal jugular vein and it’s superior bulb. These variations can be due to constitutional, racial or genetic. This anatomical knowledge of JF may help the neurosurgeons, ENT surgeons and radiologists during their clinical exploration.
Protection against Brain histopathological damage in experimental Cerebral malaria models after exposure to hyperbaric oxigent
Authors: Diah Utami Prawesty , Hadi Usman , Dachlan Yoes Prijatna , Suryokusumo Guritno , Enggar Fitri R. Loeki , Yudo Varidianto
Published: July 2021

In this study, brain damage caused by cerebral malaria was induced by parasitized erythrocyte rupture and sequestration, which led to inflammation and blood vessel damage. Therefore, this research objective to determine the effect of oxygen administration on the histopathological features and sequestration of CD3 lymphocyte T cells on Plasmodium berghei ANKA/PbA-infected vascular endothelial brain tissue of mice. The study samples consisted of 39 C57BL/6 mice, which were divided into 3 groups: G1 contained normal mice; G2 contained PbA-infected mice; G3 were mice infected with PbA, and administered HBO 2.4 ATA for 10 days straight. Histopathological examination of the of brain tissue and CD3 lymphocyte T cell expression was carried out using immuno-histochemical at the end of the study. Therefore, the results of this study indicate that HBO administration can reduce the level of parasites, can improve the histopathological features of the brain, and can reduce the sequestration of CD3 cells in the brain's blood vessels. According to the results, it can be concluded that 10 sessions of HBO 2.4 ATA exposure can reduce the level of parasites, enhance the histopathological features of brain tissue and decrease the sequestration of CD3 lymphocyte T cells.
The impact of the recovery and resilience facility on the Greek economy
Authors:   Bank of Greece, Malliaropulos Dimitris , Papageorgiou Dimitris , Vasardani Melina , Vourvachaki Evangelia
Published: July 2021

This paper assesses the macroeconomic impact of the stimulus and the structural reforms supported by the Recovery and Resilience Facility (RRF) on the Greek economy. The set-up is a Dynamic Stochastic General Equilibrium (DSGE) model that is augmented to account for the main features of Greece’s plan under the RRF framework. The results suggest that the full and timely implementation of the Recovery and Resilience Plan (RRP) implies significant benefits to the Greek economy. Real GDP, private investment and employment can potentially increase by 6.9%, 20% and 4%, respectively, by 2026. Tax revenues also increase, creating fiscal space that can be used to further boost economic activity. The implementation of structural reforms included in the RRP is necessary for maintaining important benefits also in the long run. The results indicate that the potential increase in long-run GDP from selected quantifiable reforms ranges between 6% and 9.9%, with gains extending to other macro variables.
The impact of economic uncertainty and inflation uncertainty on the Greek economy
Authors:   Bank of Greece, Balfoussia Hiona , Louzis Dimitrios P.
Published: July 2021

We provide estimates of economic uncertainty and inflation uncertainty for the Greek economy, and consider their time-varying impact on the corresponding macroeconomic variables, i.e. GDP growth and inflation. We find that, in both cases, the degree of uncertainty varies over time. Ιts impact on the underlying variable also fluctuates and is statistically significant and negative during both the global financial crisis and the Greek sovereign debt crisis, as well as during the COVID-19 pandemic. Thus, during these periods, uncertainty weighs on the economy’s fundamentals. Our findings have a number of policy implications, including that the extraordinary policy measures taken to contain the economic impact of the COVID-19 pandemic should be withdrawn gradually and with due caution, as any increase in uncertainty may have an adverse effect on economic activity and a deflationary impact on prices.
Detección de Mastitis Subclínica Bovina y factores asociados, en fincas lecheras de la Provincia del Cañar – Biblián, Ecuador
Authors: Cuenca-Condoy Mercy , García-Bracho Dionel , Reinoso-García Lourdes , González-Rojas Juan , Torracchi-Carrasco José
Published: July 2021

El objetivo del estudió fue detectar la presencia de Mastitis Subclínica Bovina (MSB) y factores asociados a la enfermedad, en 23 fincas lecheras de la provincia del Cañar, parroquia Biblián, Ecuador, que se encuentran conformadas por rangos de 5 a 29 vacas en producción lechera; se evaluaron 360 vacas (1.440 cuartos mamarios), de las cuales se tomaron muestras de leche y se realizó la prueba de campo California Mastitis Test (CMT) verificando la categoría de mastitis subclínica (MS). Las muestras de leche positivas a CMT fueron recolectadas en frascos estériles por duplicado y transportadas al laboratorio conservando la cadena de frío para realizar el conteo de células somáticas (CCS). Los factores asociados a MS fueron tipo de ordeño y prácticas de manejo. Los resultados determinaron una prevalencia de 9,1 % de MSB en la zona de estudio y de 56,5 % a nivel de hatos ganaderos. En cuanto a factores asociados se encontró que el ordeño mecánico y la aplicación de algunas prácticas, como el secado de los pezones con toalla no individual, incrementa el riesgo en las vacas de padecer la enfermedad. Se concluye que la prevalencia de MSB a nivel de hatos ganaderos es alta y que el secado de pezones con toalla colectiva incrementa el riesgo de padecer la enfermedad.
ROMANIAN`S SECURITY: EXPLAINING YOUNG CITIZENS’ PERCEPTIONS ABOUT NATIONAL SECURITY
Authors: LUȚAI Raluca , GRAD Marius
Published: July 2021

Abstract: In the last decades the issue of national security has become more transparent and a subject of interest for the common citizen. Much scholarly attention is paid to how people perceive national security and issues related to it. However, we know very little about what young citizens, members of generation Z, believe about this aspect. This paper addresses this gap in the literature and analyzes how young citizens perceive subjects related to national security. It uses Romania as a single-case study and semi-structured interviews conducted in January 2021-March 2021 with young citizens coming from different socio-demographic profiles, to explain the variation in how they understand national security. The paper seeks to test the explanatory power of several variables such as knowledge about contemporary events, media exposure and threat assessment. The paper also controls for several socio-demographic characteristics such as age, gender, education and medium of residence. The findings indicate that citizens’ perceptions are influenced by a combination of general attitudes towards the political system and society, the education factor and specific attitudes about potential threats.Keywords: Generation Z; security perception, Romania, national security.
SURFACE STRATEGY TAXONOMY: GRAMMATICAL ERRORS ANALYSIS IN THE THIRD-SEMESTER STUDENTS’ DESCRIPTIVE ESSAY
Authors: Rixha Annafi’in Nur , Alhamid Idrus , Rokhmah Siti , Ukka Syamsir Bin
Published: July 2021

English and Indonesian are grammatically different. The difference proves that the rules and the application of grammar are the difficult problems in writing English. Based on previous preliminary research, many Third-Semester students of English Education Study Program had problems using grammar. This is supported by the results of unstructured interviews by researcher against students. Then students made mistakes they cannot correct called errors. As English Education students, they must have good competence in all language skills to become a good English teacher. In the future, students will teach writing effectively if they master the grammatical understanding.This research’s objectives were to find: (1) The the types of grammatical errors based on surface strategy taxonomy found in students’ descriptive essay,(2) The dominant grammatical error based on surface strategy taxonomy found in students’ descriptive essay,(3) The factors causing students made grammatical error in writing descriptive essays.To achieve the objectives, a qualitative method is used. Data collected by observation, interview and documentation from students’ descriptive essay worksheet then analyzed using error analysis.The findings of the research: (1) Grammatical errors are Misformation (3rd Person Singular, Plural, Auxiliary Verb, Dictionaries, Preposition, Conjunction, Pronoun, Singular, Simple Present Tense, Simple Past Tense), Omission (Simple Present Tense, Agreement, Auxiliary Verb, Plural, Article, Pronoun, Conjunction, Preposition, Adverb), Addition (Simple Additions, Double Marking), Misordering (Adjective, Pronoun, Auxiliary Verb). (2) The dominant grammatical error is Misformation with 47.05% from 170 errors. (3) The factors causing error are Interlingual and Intralingual.
La música reggae en Panamá. Breve reseña histórica
Authors: De Gracia Guillermina-Itzel
Published: July 2021

En 1985, cuando Leonardo Renato Aulder sacó a la luz por primera vez la canción titulada ¿Qué es lo que el D.E.N.I. puede hacer? las radios emisoras panameñas se transformaron y es muy probable que nadie, en ese momento, tuviese idea de la revolución musical que esto ocasionaría. Renato (como sería conocido a partir de ese momento) se convertiría en el primer panameño en grabar este género en español, que a lo largo de estas tres últimas décadas se ha propagado por el mundo y ha sido la génesis de nuevos géneros musicales.

En Panamá nace un género musical distinto, pero que comparte un mismo contexto cultural con Jamaica. A lo largo de su historia el reggae en español ha impactado muchas partes de América Latina y ha acumulado tanto simpatizantes como detractores.

Este articulo desmenuza los inicios de esta música en Panamá, analizando las características históricas y culturales que hicieron que este país no solo fuese el primer lugar donde se produjo y comercializó el reggae en español, sino también donde surgieron el calypso, el kompas o el haitiano, en ese idioma.
Las matronas y los usos políticos del sheshand en dos historias (ficcionales) sobre la isla de San Andrés
Authors: Silva-Peña Eduardo
Published: July 2021

Este texto analiza la manera en que el chisme, conocido en algunos lugares de la isla de San Andrés como sheshand y entendido como un acto de habla con potencialidad política que escenifica las tensiones narrativas que marcan la política y la cultura en el Caribe, se manifiesta por medio de la acción de dos personajes de matronas caribeñas: la big mamma en la obra de teatro Henrietta de la Fundación Teatral Trasatlántico y Lorenza Vallejo en Los Pañamanes de Fanny Buitrago. Las dos obras establecen y dan cuenta de un alto contenido histórico en sus narrativas en clave femenina y caribeña, ubicándose a su vez en el contexto de dos momentos icónicos en la historia de la isla de San Andrés: la declaración de emancipación en 1849 y la declaratoria de Puerto Libre en 1953.
Oralidad artística: arte performativa y ‘desocultamiento del Ser’ en la era de la postmodernidad
Authors: Benítez-Schaefer Luciana
Published: July 2021

El presente trabajo pretende explicar la vigencia e importancia de las prácticas orales artísticas a partir de la conceptualización de la performance oral como síntesis de dos elementos opuestos, pero complementarios: la evanescencia propia del habla y la necesidad ontológica de la “verdad” (en el sentido fenomenológico del término). Esta búsqueda remite al concepto de “universalidad” en una era postmoderna, donde ambas nociones tienden a ser cuestionadas. Desde una perspectiva dinámica del lenguaje como juego (L. Wittgenstein) y de la comunicación como proceso que incluye elementos verbales y no verbales (Teoría de Sistemas Dinámicos, desde los estudios de P.  Reygadas y S. Shanker), la autora brinda un sustento teórico a la vitalidad de este arte ancestral en la época actual. Así, esta investigación promueve la práctica de la oralidad como recurso para asimilar y comprender el universo cultural que nos precede y nos rodea.
EVALUASI PENERAPAN EVOLUTIONARY ALGORITHM UNTUK PEMECAHAN TRAVELING SALESMAN PROBLEM
Authors: Ruswan Suwarman Herman
Published: July 2021

Komputasi dalam memecahkan Traveling Salesman Problem (TSP) dihadapkan pada kombinasi solusi yang meningkat secara eksponensial seiring dengan bertambahnya node pada rute. Oleh karena itu, diperlukan pengembangan metode dalam memecahkannya. Penelitian ini akan menggunakan Evolutionary Algorithm (EA), salah satu algoritma heuristik untuk menangani beban komputasi tersebut. Walaupun demikian algoritma heuristik selalu dihadapkan dengan tantangan konvergensi. Konvergensi solusi yang diperoleh dari algoritma eksak seperti Linear Programming (LP) tidak selalu bisa dicapai oleh algoritma heuristik. Solver merupakan add in program Microsoft Excel yang mampu memecahkan masalah komputasi TSP melalui pendekatan EA (heuristik) dan simplex LP (eksak). Tujuan penelitian ini adalah pertama mendapatkan gambaran mengenai kinerja suatu metode heuristik EA dalam memecahkan TSP. Kedua, mendapatkan gambaran mengenai kompleksitas yang dihasilkan akibat penambahan jumlah node pada TSP. Sampel yang digunakan adalah jarak gudang dan 14 gerai minimarket terdekat di Kota Bandung. TSP untuk 15 node tersebut dipecahkan menggunakan EA dan kemudian dibandingkan dengan luaran dari hasil komputasi LP. Hasil perbandingan dianalisis secara deskriptif yaitu dengan melihat pola-pola yang dihasilkan oleh kedua metode. Semua komputasi baik EA dan LP menggunakan fitur yang disediakan oleh Microsoft Excel Solver. Hasil penelitian menunjukkan bahwa EA memiliki kualitas dalam mendekati konvergensi LP dengan baik dan layak digunakan dalam mendapatkan solusi pada jumlah node yang banyak. Hal ini ditunjukkan oleh pola luaran dari kedua metode dan linearitas yang dihasilkannya. Selain itu juga ditunjukkan pada node yang cukup banyak pada kasus ini, LP menghasilkan solusi tidak layak, di pihak lain solusi tersebut masih bisa diberikan oleh EA.
MERANCANG ALAT BANTU PROSES TAPPING ULIR BUSHING BAGIAN BODY HULL KENDARAAN TEMPUR
Authors: Sastradiharja Jahny , Pardiyono Ragil , Pity Aldo
Published: July 2021

Penelitian ini dilakukan pada proses pembuatan bushing yaitu salah satu komponen pendukung kendaraan tempur yang berfungsi sebagai dudukan (mounting). Penelitian ini akan merancang alat bantu untuk, pemutaran tap yang tidak seimbang yang menyebabkan tingginya persentase cacat ulir bushing. Tahapan dalam merancang alat bantu dimulai dengan observasi awal, dilanjutkan proses pengumpulan data, proses merancang alat bantu menggunakan metode jig and fixture, melakukan simulai (monte carlo dan finite element method), dan proses terakhir menganalisis hasil perancangan alat bantu. Hasil akhir dari penelitian ini adalah rancangan alat bantu proses tapping ulir bushing, dapat meminimumkan waktu proses yakni penurunan dari 414,91 detik sebelum perancangan menjadi 258,09 detik, memperbaiki postur kerja operator awalnya operator bekerja membungkuk menjadi lebih tegak, dan pekerjaan tapping lebih efektif dan efisien
Manifestations buccales chez les enfants et adolescents infectes par le VIH à Kinshasa (RDC) et facteurs associés
Authors: Bakama L , Dilu F , Lelo P , Kowe N , Bakambana G , Songo F , Al Et.
Published: July 2021

Objectifs : Mesurer l'ampleur des manifestations buccales chez les enfants et adolescents VIH positif fréquentant le milieu hospitalier de Kinshasa et en identifier les facteurs associés. Méthodes : Il s'est agi d'une étude transversale analytique, conduite dans deux hôpitaux pédiatriques de Kinshasa (RDC), du 01 mai 2017 au 15 janvier 2018, chez des enfants et adolescents VIH positif âgés de 0 à 19 ans. Les manifestations buccales ont été diagnostiquées selon les critères cliniques de Ramos-Gomez et al. La régression logistique, en analyse univariée et multivariée, exprimée en Odds ratio (OR) avec leur intervalle de confiance estimée à 95%, a été exploitée pour rechercher les facteurs associés aux manifestations buccales.Résultats : Quatre cent vingt-deux patients étaient inscrits (219 filles et 203 garçons), l'âge médian était de 13 ans (IIQ : 10 ans–16 ans) ; 402 patients (95,3%) recevaient les ARV ; 359 patients (85,1%) présentaient une ou plusieurs  manifestations buccales. La carie dentaire était présente chez 161 patients (38,9%). Le sexe féminin (ORa : 2,478 ; IC à 95 % [1,30 – 4,69]) ; p = 0,005) et  l'hygiène buccale modérée et mauvaise (ORa : 4,54 ; IC à 95% [1,74 – 11,835] ; p = 0,006) étaient les facteurs associés aux manifestations buccales.Conclusion : Les manifestations buccales chez les enfants et adolescents VIH positif  sont encore très fréquentes dans notre milieu, à l'ère de la thérapie antirétrovirale. Cette situation indique la nécessité d'inclure la santé buccodentaire dans la prise en charge des enfants et adolescents VIH positif.
CELLULITE ORBITAIRE CHEZ L'ENFANT : A PROPOS DE DEUX CAS
Authors: Diallo S , Guindo A , Elien G , Coulibaly B , Diallo H , Coulibaly OM , Sylla F
Published: July 2021

Les cellulites orbitaires sont définies par une infection aigue du contenu orbitaire qui touche plus fréquemment l'enfant. Nous rapportons deux cas cliniques de cellulite orbitaire chez deux enfants âgés respectivement de 8 et 11 ans qui avaient présenté une cellulite orbitaire secondaire à une conjonctivite bactérienne non traitée. Dans les deux cas : La tomodensitométrie orbitaire avait mise en évidence une cellulite orbitaire diffuse et l'analyse bactériologique du prélèvement avaient mise en évidence le staphylococcus aureus. Le traitement comportait une antibiothérapie par voie locale et orale. L'évolution était favorable au bout de 7 jours de traitement avec résorption complète de la cellulite. La cellulite orbitaire est une affection peu fréquente. Son évolution est toujours grave en l'absence d'un traitement.
Transtornos mentais: assistência de enfermagem na psicose puerperal
Authors: Ferreira Bruna Luana Raulino , Lima Jayonara Yuri Silva , Cavalcante Keylane de Oliveira , Silva Shirley Lima , Holanda Thâmara Isadora da Silva
Published: July 2021

O pós-parto é um tempo de grandes alterações hormonais, físicas e psicológicas que se estende até o quadragésimo dia após o nascimento do bebê. É o período onde surge a presença de alguns transtornos ligados diretamente às primeiras emoções e vivências maternas. Este artigo buscou descrever a assistência prestada pelos profissionais enfermeiros às mulheres com apresentação de psicose puerperal. Trata-se de uma pesquisa descritiva, de revisão integrativa, cuja pesquisa foi realizada através de consulta de artigos científicos, veiculados na base de dados SCOPUS e no portal PUBMED, utilizando os seguintes descritores: distúrbios puerperais, saúde materna e enfermeiro. Tais descritores submetidos ao operador boleando AND e OR. Após passar pelo refinamento de pesquisa foram inclusos 8 artigos, os mesmo tiveram sua leitura feita na integra e seus dados foram extraídos e organizados para avaliar a aquisição de conhecimento pelo tipo de estudo realizado. As pesquisas enfatizaram a importância da enfermagem junto a psicose puerperal, especificou alguns preditores para desenvolvimento da doença e descreveram suas possíveis intervenções em toda a rede de saúde como em acompanhamento do pré-natal com a escuta e rastreio de incidência da psicose , em ambiente hospitalar com a manutenção do autocuidado, criação de vínculo com a paciente e em ambiente domiciliar com uma abordagem mais individualizada incorporando suas necessidades emocionais específicas e manutenção de possíveis recaídas. Salienta-se ainda a necessidade de aprofundamento sobre o tema e o impacto que a psicose pode desenvolver nas relações pessoais.