bluuebunny/crossref_metadata_2025 huggingface dataset:
Use of Metabolomic Profiling to Understand Variability in Adiposity Changes Following an Intentional Weight Loss Intervention in Older Adults
Authors: Quillen Ellen E. , Beavers Daniel P. , O’Brien Cox Anderson , Furdui Cristina M. , Lee Jingyun , Miller Ryan M. , Wu Hanzhi , Beavers Kristen M.
Published: October 2020

Inter-individual response to dietary interventions remains a major challenge to successful weight loss among older adults. This study applied metabolomics technology to identify small molecule signatures associated with a loss of fat mass and overall weight in a cohort of older adults on a nutritionally complete, high-protein diet. A total of 102 unique metabolites were measured using liquid chromatography-mass spectrometry (LC-MS) for 38 adults aged 65–80 years randomized to dietary intervention and 36 controls. Metabolite values were analyzed in both baseline plasma samples and samples collected following the six-month dietary intervention to consider both metabolites that could predict the response to diet and those that changed in response to diet or weight loss.Eight metabolites changed over the intervention at a nominally significant level: D-pantothenic acid, L-methionine, nicotinate, aniline, melatonin, deoxycarnitine, 6-deoxy-L-galactose, and 10-hydroxydecanoate. Within the intervention group, there was broad variation in the achieved weight-loss and dual-energy x-ray absorptiometry (DXA)-defined changes in total fat and visceral adipose tissue (VAT) mass. Change in the VAT mass was significantly associated with the baseline abundance of α-aminoadipate (p = 0.0007) and an additional mass spectrometry peak that may represent D-fructose, myo-inositol, mannose, α-D-glucose, allose, D-galactose, D-tagatose, or L-sorbose (p = 0.0001). This hypothesis-generating study reflects the potential of metabolomic biomarkers for the development of personalized dietary interventions.
The Extract of Arctium lappa L. Fruit (Arctii Fructus) Improves Cancer-Induced Cachexia by Inhibiting Weight Loss of Skeletal Muscle and Adipose Tissue
Authors: Han Yo-Han , Mun Jeong-Geon , Jeon Hee Dong , Yoon Dae Hwan , Choi Byung-Min , Kee Ji-Ye , Hong Seung-Heon
Published: October 2020

Background: Cachexia induced by cancer is a systemic wasting syndrome and it accompanies continuous body weight loss with the exhaustion of skeletal muscle and adipose tissue. Cancer cachexia is not only a problem in itself, but it also reduces the effectiveness of treatments and deteriorates quality of life. However, effective treatments have not been found yet. Although Arctii Fructus (AF) has been studied about several pharmacological effects, there were no reports on its use in cancer cachexia. Methods: To induce cancer cachexia in mice, we inoculated CT-26 cells to BALB/c mice through subcutaneous injection and intraperitoneal injection. To mimic cancer cachexia in vitro, we used conditioned media (CM), which was CT-26 colon cancer cells cultured medium. Results: In in vivo experiments, AF suppressed expression of interleukin (IL)-6 and atrophy of skeletal muscle and adipose tissue. As a result, the administration of AF decreased mortality by preventing weight loss. In adipose tissue, AF decreased expression of uncoupling protein 1 (UCP1) by restoring AMP-activated protein kinase (AMPK) activation. In in vitro model, CM increased muscle degradation factors and decreased adipocytes differentiation factors. However, these tendencies were ameliorated by AF treatment in C2C12 myoblasts and 3T3-L1 cells. Conclusion: Taken together, our study demonstrated that AF could be a therapeutic supplement for patients suffering from cancer cachexia.
Attenuation of Spatial Memory in 5xFAD Mice by Halting Cholinesterases, Oxidative Stress and Neuroinflammation Using a Cyclopentanone Derivative
Authors: Ullah Rahim , Ali Gowhar , Ahmad Nisar , Akram Muhammad , Kumari Geeta , Amin Muhammad Usman , Umar Muhammad Naveed
Published: October 2020

Alzheimer’s disease (AD) is an irreversible and chronic neurological disorder that gradually destroys memory and thinking skills. The research study was designed to investigate the underlying molecular signaling involved in the neuroprotective effects of cyclopentanone derivative i.e., 2-(hydroxyl-(3-nitrophenyl)methyl)cyclopentanone (3NCP) as a therapeutic agent for AD. In this study, In vivo studies were carried out on a well-known 5xFAD mice model using different behavioural test models such as open field, rotarod, Morris water maze (MWM), and Y-maze tests. Furthermore, in vitro cholinesterase inhibition activity assays were carried out. The frontal cortex (FC) and hippocampus (HC) homogenates were tested for the levels/activities of cholinesterases, glutathione (GSH), glutathione S-transferase (GST), and catalase. Furthermore, the hippocampal expression of inflammatory cytokines was observed via RT-PCR and western blot. The results of in vivo studies show an enhancement in the learning behavior. The 3NCP treatment reduced latency time in MWM and Y-maze tests, also increase spontaneous alternation indicate significant effect of 3NCP on memory. Furthermore, open field and rotarod studies revealed that 3NCP does not cause motor coordination deficit. The results of the in vitro studies revealed that the IC50 values of the 3NCP against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) were 16.17 and 20.51 µg/mL, respectively. This decline in AChE and BChE was further supported by ex vivo studies. Further, the 3NCP mitigates the GSH level, GST, and catalase activities in HC and FC. The mRNA and protein expression of inflammatory cytokines (IL-1β, IL-6, TNF-α) markedly declined in RT-PCR and western blotting. The results of the current study conclusively demonstrate that 3NCP reduces oxidative stress and mitigates neuroinflammation in 5xFAD mice, implying that 3NCP may be a potential therapeutic candidate for AD treatment in the future.
A New Case Manager for Diabetic Patients: A Pilot Observational Study of the Role of Community Pharmacists and Pharmacy Services in the Case Management of Diabetic Patients
Authors: La Regina Raffaele , Pandolfi Dario , Stabile Nicola , Beloni Lucio , Glisenti Fulvio , Griggio Paola , La Regina Micaela , La Regina Giuseppe
Published: October 2020

The adherence of type 2 diabetes mellitus (DM2) patients with an individual care plan (ICP) is often not satisfactory, nor does it allow for a significant improvement in outcome, because of poor accessibility to services, poor integration of pathway articulations, poor reconciliation with the patient’s life, or the lack of a constant reference person. The purpose of this study was to evaluate the contribution of community pharmacists and pharmacy services in improving adherence with periodic controls in DM2. The study was conducted at a rural pharmacy. A sample of 40 patients was calculated with respect to a historical cohort and subsequently enrolled. Clinical and personal data were collected in an electronic case report form. Pharmacists acting as a case manager followed patients carrying out their ICP developed by an attending physician. Some of the activities foreseen by the ICP, such as electrocardiogram, fundus examination, and self-analysis of blood and urine, were carried out directly in the pharmacy by the pharmacist through the use of telemedicine services and point of care units. Activities that could not be performed in the pharmacy were booked by the pharmacist at the accredited units. Examination results were electronically reported by the pharmacist to the attending physician. The primary endpoint was the variation in patient adherence with the ICP compared to a historical cohort. Secondary endpoints were variation in waiting time for the examinations, mean percentage change in glycated hemoglobin (HbA1c) and low-density lipoprotein (LDL) cholesterol levels and blood pressure, impact on healthcare-related costs, and perceived quality of care. Adherence to the ICP significantly increased. Waiting times were reduced and clinical outcomes improved with conceivable effects on costs. Patients appreciated the easier access to services. Community pharmacists and pharmacy services represent ideal actors and context that, integrated in the care network, can really favor ICP adherence and obtain daily morbidity reduction and cost savings through proper disease control and an early diagnosis of complications.
Schizophrenic Psychosis Symptoms in a Background of Mild-To-Moderate Carnitine Palmitoyltransferase II Deficiency: A Case Report
Authors: Wickramasekara Rochelle N. , Lookian Pashayar P. , Ngo Jeannie , Shibata Annemarie , Stessman Holly A. F.
Published: October 2020

Schizophrenia is a multifaceted mental illness characterized by cognitive and neurobehavioral abnormalities. Carnitine palmitoyltransferase II (CPT II) deficiency is a metabolic disorder resulting in impaired transport of long-chain fatty acids from the cytosol to the mitochondrial inner membrane, where fatty acid β-oxidation takes place. Here, we present an interesting clinical case of an adolescent male that presented with psychosis and a history of mild-to-moderate CPT II deficiency. To identify germline genetic variation that may contribute to the phenotypes observed, we performed whole-exome sequencing on DNA from the proband, unaffected fraternal twin, and biological parents. The proband was identified to be homozygous for the p.Val368Ile and heterozygous for the p.Met647Val variant in CPT2. Each of these variants are benign on their own; however, their combined effect is unclear. Further, variation was identified in the dopamine β-hydroxylase (DBH) gene (c.339+2T>C), which may contribute to decreased activity of DBH; however, based on the patient’s presentation, severe DBH deficiency is unlikely. In conclusion, the variants identified in this study do not clearly explain the observed patient phenotypes, indicating that the complex phenotypes are likely caused by an interplay of genetic and environmental factors that warrant further investigation.
Vehicular Sensor Network and Data Analytics for a Health and Usage Management System
Authors: Ranasinghe Kavindu , Kapoor Rohan , Gardi Alessandro , Sabatini Roberto , Wickramanayake Vishwanath , Ludovici David
Published: October 2020

Automated collection of on-vehicle sensor data allows the development of artificial intelligence (AI) techniques for vehicular systems’ diagnostic and prognostic processes to better assess the state-of-health, predict faults and evaluate residual life of ground vehicle systems. One of the vital subsystems, in terms of safety and mission criticality, is the power train, (comprising the engine, transmission, and final drives), which provides the driving torque required for vehicle acceleration. In this paper, a novel health and usage monitoring system (HUMS) architecture is presented, together with dedicated diagnosis/prognosis algorithms that utilize data gathered from a sensor network embedded in an armoured personnel carrier (APC) vehicle. To model the drivetrain, a virtual dynamometer is introduced, which estimates the engine torque output for successive comparison with the measured torque values taken from the engine control unit. This virtual dynamometer is also used in conjunction with other sensed variables to determine the maximum torque output of the engine, which is considered to be the primary indicator of engine health. Regression analysis is performed to capture the effect of certain variables such as engine hours, oil temperature, and coolant temperature on the degradation of maximum engine torque. Degradations in the final drives system were identified using a comparison of the temperature trends between the left-hand and right-hand final drives. This research lays foundations for the development of real-time diagnosis and prognosis functions for an integrated vehicle health management (IVHM) system suitable for safety critical manned and unmanned vehicle applications.
egoDetect: Visual Detection and Exploration of Anomaly in Social Communication Network
Authors: Pu Jiansu , Zhang Jingwen , Shao Hui , Zhang Tingting , Rao Yunbo
Published: October 2020

The development of the Internet has made social communication increasingly important for maintaining relationships between people. However, advertising and fraud are also growing incredibly fast and seriously affect our daily life, e.g., leading to money and time losses, trash information, and privacy problems. Therefore, it is very important to detect anomalies in social networks. However, existing anomaly detection methods cannot guarantee the correct rate. Besides, due to the lack of labeled data, we also cannot use the detection results directly. In other words, we still need human analysts in the loop to provide enough judgment for decision making. To help experts analyze and explore the results of anomaly detection in social networks more objectively and effectively, we propose a novel visualization system, egoDetect, which can detect the anomalies in social communication networks efficiently. Based on the unsupervised anomaly detection method, the system can detect the anomaly without training and get the overview quickly. Then we explore an ego’s topology and the relationship between egos and alters by designing a novel glyph based on the egocentric network. Besides, it also provides rich interactions for experts to quickly navigate to the interested users for further exploration. We use an actual call dataset provided by an operator to evaluate our system. The result proves that our proposed system is effective in the anomaly detection of social networks.
Sensors Made of Natural Renewable Materials: Efficiency, Recyclability or Biodegradability—The Green Electronics
Authors: Piro Benoît , Tran Hoang Vinh , Thu Vu Thi
Published: October 2020

Nowadays, sensor devices are developing fast. It is therefore critical, at a time when the availability and recyclability of materials are, along with acceptability from the consumers, among the most important criteria used by industrials before pushing a device to market, to review the most recent advances related to functional electronic materials, substrates or packaging materials with natural origins and/or presenting good recyclability. This review proposes, in the first section, passive materials used as substrates, supporting matrixes or packaging, whether organic or inorganic, then active materials such as conductors or semiconductors. The last section is dedicated to the review of pertinent sensors and devices integrated in sensors, along with their fabrication methods.
A Cloud-Based Tool for Integrating Occupational Risk Assessment Within Management Systems for SMEs
Authors: De Merich Diego , Gnoni Maria Grazia , Malorgio Brunella , Micheli Guido J. L. , Piga Giusi , Sala Guido , Tornese Fabiana
Published: October 2020

About 67% of workers employed in the industrial and service sectors in the European Union are currently contracted by Small- and Medium-sized Enterprises (SMEs), which represent the economic heart of the European economy. However, this strength is counterbalanced by a considerably higher overall accident rate compared to Large Enterprises (LEs), and this trend seems to be confirmed worldwide. Moreover, most available tools for risk assessment and occupational health and safety (OHS) management are originally designed to fit the needs of LEs, resulting in a gap for SMEs. Therefore, the effective management of OHS in SMEs has become a crucial issue for researchers, practitioners and policymakers, aiming to improve the social and economic sustainability of small companies. The main purpose of this study is to provide guidelines to implement effective risk assessment processes and integrate them with OHS management systems in SMEs. A literature analysis of risk assessment and OHS management in SMEs highlights the main findings and gaps. Then, the three-phases methodology adopted is presented, outlining the main steps and outputs of the project. Finally, the web-based software tool for OHS risk analysis and management, designed to answer the specific needs of SMEs, is presented.
Interdisciplinary Cooperative Educational Approaches to Foster Knowledge and Competences for Sustainable Development
Authors: Bassachs Marcel , Cañabate Dolors , Serra Teresa , Colomer Jordi
Published: October 2020

The objective of this paper is to prove that interdisciplinary educational approaches foster knowledge and competences for sustainable development in primary education. The intervention methodology employed is an educational and pedagogical approach to teaching science through physical activities and is based on developing dynamic reflective and cooperative learning environments to strengthen teaching–learning relationships. The educational approach included analyzing students’ reflections from their focus groups, in which five categories of cooperative learning: positive interdependence, individual accountability, promotive interaction, the appropriate use of social skills, and group processing, were considered. The results show that, to a significant statistical degree, when the interdisciplinary approaches were adopted the primary school students reached higher levels of understanding, reflective and critical thinking development, and that cooperative learning provided them with a greater perception of sustainable development competences through systems and critical thinking, analysis, interpersonal relationships and collaboration, and strategic action.
The Perception of CSR Activities in a Selected Segment of McDonald’s Customers in the Czech Republic and Its Effect on Their Purchasing Behavior—A Case Study
Authors: Hommerová Dita , Šrédl Karel , Vrbková Lucie , Svoboda Roman
Published: October 2020

This case study presents the results of research which focused on the perception of corporate social responsibility (CSR) activities by customers in a target segment of a selected fast-food chain in Czechia and its impact on their purchasing behavior. A total of 264 duly completed questionnaires were analyzed. Furthermore, the article presents the specifics of the development and fulfillment of the CSR concept in Czechia and at the same time points out differences in the implementation of the McDonald’s CSR concept at the global level compared to its implementation at the national level in the Czech environment. Statistical dependence between age as well as education and understanding the essence of CSR was proven, while no correlation was identified when it comes to gender. Among factors affecting the purchasing decision-making process in the target segment of a selected company, CSR activities (i.e., the environmental mindset of the company) rank fourth after price, quality, and recommendations from friends. The results of this research can be applied to other restaurant establishments in Czechia, taking into consideration their target segments, and used for further research into the awareness and effect of CSR on consumer purchasing behavior and its comparison at the international level.
Internal Control Personnel’s Experience, Internal Control Weaknesses, and ESG Rating
Authors: Koo Ja Eun , Ki Eun Sun
Published: October 2020

Effective internal control is expected to have a positive effect on Environmental, Social, and Governance (ESG) ratings, which are an indicator of corporate sustainability, as it ensures improvements in efficiency and effectiveness in operations, reliable reports, and compliance with applicable laws and regulations. However, no matter how well an internal control system is designed, internal control quality deteriorates if internal control (IC) personnel do not understand the firm’s business or lack accounting experience. This study first explores the relationship between ESG ratings and internal control weaknesses (ICWs). We then examine two types of career experience of IC personnel—length of service and accounting experience—and their effect on ICWs. We conduct logit regression analyses using the data of 1876 non-financial listed firms in Korea. The results show that ICW firms have low ESG ratings. We also find that the accounting experience of IC personnel is more closely related to ICWs than the length of service. This implies that the accounting expertise of IC personnel may have a greater effect on internal control quality than the understanding of a firm’s business. Overall, our findings provide evidence that firms must have IC personnel with sufficient accounting expertise for sustainable management.
Application of Bioengineering Techniques as Geo-Hydrological Risk Mitigation Measures in a Highly Valuable Cultural Landscape: Experiences from the Cinque Terre National Park (Italy)
Authors: Pepe Giacomo , Baudinelli Elena , Zanini Matteo , Calcaterra Domenico , Cevasco Andrea , Scarpellini Patrizio , Firpo Marco
Published: October 2020

In this work, experiences from the use of bioengineering techniques as geo-hydrological risk mitigation measures within the territory of Cinque Terre National Park (Eastern Liguria, Italy) after an extreme rainfall event that occurred on 25 October 2011 are described. This rainstorm was responsible for intense erosive processes and triggered numerous shallow landslides, causing severe structural and economic damage. After this disastrous event, many bioengineering interventions were planned to stabilize the most unstable slopes and the most problematic streams. Based on multidisciplinary studies and field surveys, an inventory of the executed bioengineering works was compiled. Subsequently, on the basis of expert judgement, both the efficiency and effectiveness of the works three years after their construction were examined. Furthermore, the compliance of the executed works with the design requirements was analysed. This study revealed that some of the investigated works lack post-intervention maintenance and require the adoption of remedial measures aimed at improving the biotechnical functions of live materials, which are often ineffective. This case study highlights the importance of technical aspects that should be considered during the design phase of bioengineering works, especially when implemented within protected areas. Specifically, it would be greatly helpful to define instructions for post-intervention maintenance and monitoring and to perform vegetational studies. Considering the great cultural and natural heritage of the study area, the obtained results are expected to provide useful information for the definition of guidelines for the best practices to be adopted when future bioengineering works are planned for geo-hydrological risk management purposes.
Factors to Foster Organizational Sustainability in Tourism SMEs
Authors: Núñez-Ríos Juan E. , Sánchez-García Jacqueline Y. , Rojas Omar G. , Olivares-Benitez Elias
Published: October 2020

Small and medium-sized tourism companies (SMEs) strongly depend on their collaborators to achieve competitiveness and sustainability. In this sense, these organizations need to identify those factors that help them to use their resources and efforts to achieve the aforementioned goals. This article proposes a model oriented to organizational sustainability in the tourism sector. A systemic approach was adopted to articulate this research; therefore, the soft systems methodology was applied to structure the problem and express a conceptual model that suggests relationships as an alternative solution to the expressed problem. Partial least squares path modeling was applied to statistically validate the relationships expressed in the construct. Results suggest that the relationships proposed in the construct are valid and may promote organizational sustainability. The ideas developed are restricted to the organizational domain and although the results apply in a Mexican context, this potential limitation can be offset by the multi-methodological approach proposed, extending the model’s application to other types of organizations. This study may enable scholars and managers to improve communication and inter-organizational relationships, allowing organizations to focus their strategies and efforts using systems thinking to increase responsiveness and adaptation.
A Study on the Transformation of Accounting Based on New Technologies: Evidence from Korea
Authors: Yoon Sora
Published: October 2020

This study identifies the new accounting technologies into Cloud, Artificial Intelligence, Big Data, and Blockchain, and introduces the case of Korean companies applying new technologies to their accounting process. The purpose of this study is to help understand accounting technologies and provide examples of the adoption of these technologies in actual practice. To achieve this aim of the study, a systematic review of the literature of the major academic publications and professional reports and websites was used as a research methodology. In order to select the cases, it performed the analytical process of reviewing Korean major business and economic newspaper articles. This study provides evidence from Korea to companies contemplating the transformation of their accounting process using technology. Such companies can consider the cases presented in this study as a benchmark. It also offers guidance for the application of technologies to accounting practices for businesses and related researchers. The technology transformation is expected to be accelerated, especially after COVID-19. Therefore, it is necessary to understand and explore ways to effectively apply them. Further, while new technologies offer many opportunities, associated risks and threats should be addressed.
Did Safe Cycling Infrastructure Still Matter During a COVID-19 Lockdown?
Authors: Hong Jinhyun , McArthur David , Raturi Varun
Published: October 2020

The UK government introduced strict measures (including asking people to work from home and a lockdown) to slow the spread of COVID-19 by limiting people’s movement. This led to substantial reductions in traffic, making roads much safer for cyclists. This provides a unique opportunity to study the role played by safe cycling infrastructure. Many UK cities have provided cycling infrastructure to improve safety and encourage cycling. However, access to safe cycling infrastructure varies across neighbourhoods, potentially contributing to inequality. Since roads became safer due to the unprecedented reduction in traffic during the lockdown, safe cycling infrastructure may not play a significant role during this period. On the other hand, safe cycling lanes are often connected to amenities, potentially attracting cyclists even if they confer no additional safety benefit. That is, connectivity might matter more than safety. In this study, we utilised crowdsourced cycling data and regression models to examine the extent to which cycling intensity for non-commuting purposes changes with different types of cycling infrastructure in the city of Glasgow, Scotland, UK. In addition, we selected some areas with large increases in cycling intensity and examined the surrounding environments using Google Street View. Our results showed that non-commuting cycling activities increased significantly after the government interventions on both typical roads and safe cycling lanes while much higher increases were observed on safe cycling lanes than on other roads. A further analysis showed that there were large increases in cycling volumes on both typical roads and safe cycling lanes with good amenities and connectivity, highlighting the importance of these factors when building new cycling infrastructure. Since safe cycling lanes are not equally accessible to people, providing temporary cycling lanes during the pandemic considering these conditions could encourage people to cycle more, and thereby improve their health.
Determining the Impact of High Temperature Fire Conditions on Fibre Cement Boards Using Thermogravimetric Analysis
Authors: Veliseicik Tomas , Zurauskiene Ramune , Valentukeviciene Marina
Published: October 2020

When exposed to temperatures that are progressively and rapidly raised, large dimension fibre cement boards tend to crack. This occurrence is analysed and explained for a specific issue of asymmetric growth of a curvilinear crack in high temperatures. This phenomenon occurred while performing Single Burning Item (SBI) experiments at fire loads which are higher than those used in countries of the European Union, which better reflect fire events that may occur in high-rise buildings. In such conditions, fibre cement boards crack, allowing the fire to reach the thermal insulating material which then combusts, thereby helping to spread the conflagration to upper floors. This experiment investigated the temperatures at which fibre cement boards crack, and why. Thermal analysis methods and thermogravimetric experiments were conducted on the fibre boards, followed by X-ray phase analysis investigations. During this phase, X-ray structural analysis was performed while the fibre cement was exposed to temperatures of 1000 °C. The article also presents ongoing change results when heating only composite fibre-cement board materials; phase changes that take place in high temperatures are discussed.
Metatranscriptomic Identification of Diverse and Divergent RNA Viruses in Green and Chlorarachniophyte Algae Cultures
Authors: Charon Justine , Marcelino Vanessa Rossetto , Wetherbee Richard , Verbruggen Heroen , Holmes Edward C.
Published: October 2020

Our knowledge of the diversity and evolution of the virosphere will likely increase dramatically with the study of microbial eukaryotes, including the microalgae within which few RNA viruses have been documented. By combining total RNA sequencing with sequence and structural-based homology detection, we identified 18 novel RNA viruses in cultured samples from two major groups of microbial algae: the chlorophytes and the chlorarachniophytes. Most of the RNA viruses identified in the green algae class Ulvophyceae were related to the Tombusviridae and Amalgaviridae viral families commonly associated with land plants. This suggests that the evolutionary history of these viruses extends to divergence events between algae and land plants. Seven Ostreobium sp-associated viruses exhibited sequence similarity to the mitoviruses most commonly found in fungi, compatible with horizontal virus transfer between algae and fungi. We also document, for the first time, RNA viruses associated with chlorarachniophytes, including the first negative-sense (bunya-like) RNA virus in microalgae, as well as a distant homolog of the plant virus Virgaviridae, potentially signifying viral inheritance from the secondary chloroplast endosymbiosis that marked the origin of the chlorarachniophytes. More broadly, these data suggest that the scarcity of RNA viruses in algae results from limited investigation rather than their absence.
Immune Checkpoint Inhibitors for Unresectable Hepatocellular Carcinoma
Authors: Abd El Aziz Mohamed A. , Facciorusso Antonio , Nayfeh Tarek , Saadi Samer , Elnaggar Mohamed , Cotsoglou Christian , Sacco Rodolfo
Published: October 2020

Despite the advances in screening protocols and treatment options, hepatocellular carcinoma (HCC) is still considered to be the most lethal malignancy in patients with liver cirrhosis. Moreover, the survival outcomes after failure of first-line therapy for unresectable HCC is still poor with limited therapeutic options. One of these options is immune checkpoint inhibitors. The aim of this study is to comprehensively review the efficacy and safety of immune checkpoint inhibitors for patients with HCC.
Massive Influx of Pelagic Sargassum spp. on the Coasts of the Mexican Caribbean 2014–2020: Challenges and Opportunities
Authors: Chávez Valeria , Uribe-Martínez Abigail , Cuevas Eduardo , Rodríguez-Martínez Rosa E. , van Tussenbroek Brigitta I. , Francisco Vanessa , Estévez Miriam , Celis Lourdes B. , Monroy-Velázquez L. Verónica , Leal-Bautista Rosa , Álvarez-Filip Lorenzo , García-Sánchez Marta , Masia Luis , Silva Rodolfo
Published: October 2020

Since late 2014, the Mexican Caribbean coast has periodically received massive, atypical influxes of pelagic Sargassum spp. (sargasso). Negative impacts associated with these influxes include mortality of nearshore benthic flora and fauna, beach erosion, pollution, decreasing tourism and high management costs. To understand the dynamics of the sargasso influx, we used Landsat 8 imagery (from 2016 to mid-2020) to record the coverage of sargasso in the sea off the Mexican Caribbean coastline, with a maximum reported in September 2018. Satellite image analysis also showed local differences in the quantity of beached sargasso along the coastline. Over the years, good practice for collection on the beach and for off-shore collection of sargasso have been established through trial and error, and the Mexican Government and hotel industry have spent millions of dollars on removal and off-shore detention of sargasso. Notwithstanding, sargasso also has various properties that could be harnessed in local industries. The stimulation of local industrial growth would offer alternatives to the dependence on tourism, as a circular economy, based on sargasso, is developed.
Heterogeneous Fenton-Like Catalytic Degradation of 2,4-Dichlorophenoxyacetic Acid by Nano-Scale Zero-Valent Iron Assembled on Magnetite Nanoparticles
Authors: Lv Xiaofan , Ma Yiyang , Li Yangyang , Yang Qi
Published: October 2020

Fe0@Fe3O4 nanoparticles with dispersibility and stability better than single nano zero-valent iron (nZVI) were synthesized and combined with hydrogen peroxide to constitute a heterogeneous Fenton-like system, which was creatively applied in the degradation of 2,4-dichlorophenoxyacetic acid (2,4-D). The effects of different reaction conditions like pH, hydrogen peroxide concentration, temperature, and catalyst dosage on the removal of 2,4-D were evaluated. The target pollutant was completely removed in 90min; nearly 66% of them could be mineralized, and the main intermediate product was 2,4-dichlorophenol. Synergistic effects between nZVI and Fe3O4 made the 2,4-D degradation efficiency in the Fe0@Fe3O4/H2O2 system greater than in either of them alone. More than a supporter, Fe3O4 could facilitate the degradation process by releasing ferrous and ferric ions from the inner structure. The reduction of 2,4-D was mainly attributed to hydroxyl radicals including surface-bound ∙OH and free ∙OH in solution and was dominated by the former. The possible mechanism of this Fe0@Fe3O4 activated Fenton-like system was proposed.
Late adult-onset Hereditary Sensory and Motor Neuropathy due to TECPR2 mutations
Authors: Sgobbi de Souza Paulo Victor , De Mattos Lombardi Badia Bruno , Gonçalves Eduardo Augusto , Ismael Lacerda Machado Roberta , Vieira de Albuquerque Filho José Marcos , Braga Farias Igor , Bussinger Lopes Alexandre , Bocca Vieira de Rezende Pinto Wladimir , Souza Bulle Oliveira Acary
Published: October 2020

Objective: The description of a new genetic association with late-onset axonal Charcot-Marie-Tooth disease (CMT). Method. A 57-year-old Brazilian woman presented with a slowly progressive history of paresthesia, muscle wasting and weakness in her lower limbs since age 50 years. Examination disclosed peroneal amyotrophy, bilateral pes cavus, mild distal weakness, reduced vibration, pain and temperature sensation in the the lower limbs and brisk tendon reflexes. Results. Neurophysiological studies showed chronic sensorimotor axonal polyneuropathy. Whole-genome sequencing showed compound heterozygous pathogenic variants in the TECPR2 gene (14q32.31). Conclusion. This novel genetic presentation of late-onset axonal CMT with brisk tendon reflexes associated with TECPR2.
Identification, Characterization, and Investigation of the Antimicrobial Activities of Autochthonous Lactic Acid Bacteria Isolated from Iranian Traditional Sourdoughs
Authors: Chandal Maryam , Mahjub Reza
Published: October 2020

Background: The microflora of Iranian traditional sourdoughs was investigated by microscopic and biochemical tests. All of the isolated lactic acid bacteria (LAB) belonged to the genus Lactobacillus and most of them belonged to L. plantarum species. Methods: LAB of Iranian traditional sourdoughs were selected for antimicrobial activity by measuring diameters of the inhibition zones. Results: The best result belonged to Lactobacillus casei. The supernatant of the specified species was added to specific culture media of each pathogenic organism, and then the optical density before and after adding the supernatant was measured at 600 nm by UV spectrophotometer every 2 hours. Conclusion: The results showed that L. casei had suitable bacteriostatic and fungistatic effects and can be used as a potent biopreservative agent in preparing various baked products such as all kinds of bread.
KASTEN ÖLDÜRME SUÇU (TCK m. 81)
Authors: AKBULUT Berrin
Published: October 2020

Kasten öldürme suçu Türk Ceza Kanununun (TCK’nın) 81, 82 ve 83. maddelerinde hükme bağlanmıştır. 81. maddede öldürme suçunun temel şekli, 82. maddede suçun daha fazla ceza verilmesini gerektiren nitelikli şekli, 83. maddede ise suçun ihmali şekilde işlenmesi düzenlenmiştir. Çalışma konusu 81. maddeyle sınırlı olup, 82. ve 83. madde hükümleri ayrı bir incelemede değerlendirilecektir.

TCK’nın 81. maddesinde düzenlenen kasten öldürme suçu serbest hareketli suçtur. Suçun oluşabilmesi için öldürme neticesinin gerçekleşmesi gerekir. Suç, düzenleme itibariyle mağdur ve fail açısından bir özellik göstermemektedir. Ancak suçun oluşması için insan hayatının ne zaman başladığının ve ne zaman sona erdiğinin belirlenmesi gerekir. Hayatın ne zaman başladığı konusunda doktrinde çeşitli görüşler ileri sürülmüştür. Suçun, doğrudan kastla ve olası kastla işlenmesi mümkündür. Ancak failin kastının yaralamaya mı öldürmeye mi yönelik olduğunun belirlenmesi önem arzetmektedir. Hukuka uygunluk nedenlerinin uygulanması söz konusu olabilmektedir. Ötenazi ise mevzuatımızda kabul edilmemiştir. Suçun teşebbüs halinde kalması ve iştirak halinde işlenmesi mümkün olup fikri içtima ve gerçek içtima da gerçekleşebilir.

Çalışmada suçla korunan hukuki değer, suçun unsurları, teşebbüs, iştirak ve içtima konuları incelenecektir. Bu kapsamda özellikle hayatın ne zaman başlayıp sona erdiği, nedensellik bağı çerçevesinde objektif isnadiyet, manevi unsura ilişkin belirlemeler ve buna ilişkin Yargıtay uygulamaları, hukuka aykırılık bağlamında silah kullanma yetkisi ve meşru savunma konuları değerlendirilmeye çalışılacaktır.
Effect of Parametric Variations on Electromigration in Integrated Circuits
Authors: Tallman Drew K. , Ullah Muhammad S.
Published: October 2020

This research paper focuses on the effects of electromigration in integrated circuits at the nanoscale domain. This is an investigative work that shows how various process and parametric variation effects on electromigration. With integrated circuits reaching in the nanoscale domain, electromigration is becoming more of a prominent problem. Being able to find changes into the integrated circuits to provide a better electromigration performance is crucial for future emerging nanotechnologies. Therefore, this paper will go through previous research work to show the evolution of Black’s equation and see if Black’s equation could use on nanoscale integrated circuits. Also, it will be showing future iterations of the equation and comparing them with constant variables. Besides, a comparison of aluminum and copper interconnects and how electro migration happens differently are also discussing in this paper. Then a conclusion on how Black’s equation could use with nanoscale technologies to predict the time during the occurrence of electro migration.
IMPLEMENTASI JIWA WIRAUSAHA DAN PEMANFAATAN MEDIA SOSIAL TERHADAP MINAT BERWIRAUSAHA PADA MAHASISWI PURWAKARTA
Authors: Nurhayati Ade
Published: October 2020

The research with the title of the influence of entrepreneurial spirit and the use of social media on the interest of entrepreneurship in female (case study on STIE Dr. Khez. Muttaqien and STIEB Perdana Mandiri in Purwakarta). The purpose of this study was to determine the effect of entrepreneurial spirit and the use of social media on the interest of entrepreneurship in private college students in Purwakarta. The respondent in this study were private college students in the Purwakarta economic cluster. The number of respondents in this study was determined by 95 respondents using a sampling technique called probability sampling technique. The research method used is descriptive method is a method that is carried out by collecting, presenting and analyzing data so as to provide a fairly clear picture of the object under study. This study uses a multiple linear regression analysis model with the help of IBM SPSS version 22. The results of this study shows that the variable entrepreneurial spirit and the use of social media have a positive and significant effect on the interest in entrepreneurship in female private university students in Purwakarta.
IMPLEMENTASI SISTEM PELATIHAN E-LEARNING TERHADAP KEPUASAN PEGAWAI KEMENTERIAN KELAUTAN DAN PERIKANAN MELALUI APLIKASI E-MILEA
Authors: Yulianto Wahyu
Published: October 2020

The current pandemic has disrupted the implementation of training at the Ministry of Marine Affairs and Fisheries (KKP). The training, which is usually done face-to-face, turns into online training (e-learning). The Apparatus Education and Training Center, which originally this year had the target to train Marine and Fisheries apparatuses online, as many as 1080 people changed to 2700 KKP ASN. A budget allocation of approximately 60% was distracted for handling covid-19 so that more training was carried out online using the e-Milea application. E-Milea (electronic millennial learning) is an e-learning training platform developed by the BDA KKP in providing education and training for the development of KKP ASN competencies. Based on these problems, this study aims to analyze the implementation of the e-learning training system on e-Milea user satisfaction. The system quality, information quality, and service quality variables are independent variables and the dependent variable in this study is user satisfaction. The hypothesis tested using Structural Equation Modeling with a total sample of 97 e-Milea users of Entrepreneurship Training Class 2 and 3. The results showed that the system quality, information quality, and service quality had a significant positive effect on user satisfaction. If the CTF can improve the e-learning training system, user satisfaction will also increase. This requires controlling the quality of the system, information, and services so that user satisfaction will be maintained.
Survei Persepsi Kebutuhan dan Hambatan Rumah Sakit dalam Menjalankan Fungsi Panitia Pengendalian Resistensi Antibiotik
Authors: Irwanto Ronald , Widodo Djoko , Ariyani Aziza , Adlani Hadianti
Published: October 2020

Latar Belakang: Standar Nasional Akreditasi Rumah Sakit (SNARS) edisi 1 (2018) menetapkan pengkajian pengendalian resistensi antibiotik di setiap rumah sakit di seluruh Indonesia sebagai salah satu syarat akreditasi rumah sakit. Namun, dalam pelaksanaannya, kerapkali pengendalian resistensi antibiotik mengalami banyak kendala.

Tujuan: Menilai persepsi anggota Panitia Pengendalian Resistensi Antimikroba (PPRA) terhadap hambatan dan kebutuhan rumah sakit dalam menjalankan peran PPRA.

Metode: Dilakukan survei potong lintang dengan membagikan kuesioner kepada responden 156 rumah sakit. Responden mengisi kuesioner berupa pertanyaan tertutup pilihan berganda dan memilih satu jawaban yang paling tepat. Analisa dilakuakn secara deskriptif.

Hasil: Pada survei ini diperoleh 26.92% dari 156 rumah sakit yang telah menjalankan program PPRA di rumah sakit. 65.38% menyatakan hanya sebagian dokter yang duduk sebagai anggota PPRA mampu melakukan tugasnya. 40.48% dari responden rumah sakit yang telah menjalankan program PPRA mengatakan bahwa tidak adanya sistem implementasi merupakan kesulitan utama dalam menjalankan program PPRA. Sementara 61.90% mengatakan anggota PPRA rumah sakitnya baru setengah mampu melakukan restriksi antibiotik. 93.86% dari 114 responden rumah sakit yang belum menjalankan program PPRA menyatakan saat ini yang paling dibutuhkan adalah konsep yang jelas untuk menjalankan program PPRA.

Kesimpulan: Sebagaian besar responden berpersepsi bahwa hanya sebagian dokter yang mampu menjalankan tugas-tugasnya sebagai anggota PPRA di rumah sakit. Kebutuhan terbesar dalam menjalankan PPRA di rumah sakit adalah konsep yang jelas, agar antibiotik dapat diberikan sesuai Panduan Penggunaan Antibiotik (PPAB), program restriksi dan penggunaan antibiotik dapat dilakukan secara benar.
Optimalisasi Pelaksanaan Discharge Planning Secara Terintegrasi di Ruang Rawat Inap X RS Militer Jakarta
Authors: HARIANJA FRISKA
Published: October 2020

Masalah Mutu: Tuntutan pelayanan kesehatan yang berkualitas tinggi menjadi fokus penting dalam era reformasi sistem perawatan kesehatan. Salah satu masalah penting dalam pelayanan kesehatan di rumah sakit (RS) adalah pelaksanaan dan pendokumentasian Perencanaan Pemulangan Pasien (P3) atau yang sering dikenal dengan discharge planning. Rendahnya peran perawat yang disebabkan pemahaman dan Pengetahuan dalam pelaksanaan P3 menjadi tidak optimal dilakukan. Selain itu, kurangnya motivasi dan komunikasi yang tidak baik antar tenaga kesehatan menjadi faktor pendukung ketidakoptimalam pelaksanaan P3, sehingga berdampak pada peningkatan readmission dan rerata lama rawat, menurunnya tingkat kepuasan dan loyalitas pasien, serta meningkatkan cost efektif RS. 

Pilihan Solusi: Dilakukan penyusunan perencanaan draft Standar Prosedur Operasional (SPO) pelaksanaan P3 dan pengoptimalan formulir discharge planning, pengkajian keperawatan awal rawat inap, edukasi terintegrasi, Catatan Perkembangan Pasien Terintegrasi (CPPT), dan resume keperawatan yang telah dimiliki oleh RS, dilanjutkan dengan hearing expert, sosialisasi, dan uji coba di ruangan rawat inap melati. 

Implementasi: Proses implementasi P3 mengalami peningkatan yang signifikan sebesar 33,6% sedangkan pada evaluasi pelaksanaan P3 sebesar 36,6%. 

Evaluasi dan Pembelajaran: Pelaksanaan P3 pada proses penetapan diagnosis keperawatan P3, intervensi, implementasi, serta evaluasi masih perlu dilakukan supervisi oleh kepala ruangan dan perlunya peningkatan peran kepala bidang keperawatan untuk memberikan program pelatihan secara khusus kepada perawat pelaksana dan Perawat Penanggung Jawab Asuhan (PPJA) dalam meningkatkan pelaksanaan dan pendokumentasian P3 di ruangan secara optimal. 

Kata kunci: P3, manajemen asuhan keperawatan, kontinuitas perawatan, RS Militer Jakarta
PENGARUH RENDAHNYA PEMAHAMAN FUNGSI MANAJEMEN SDM, TERHADAP KINERJA KARYAWAN (STUDI KASUS YAYASAN AL-GHUFRON PAMEKASAN)
Authors: AFA AKH.FAWAID , Fahrurozi Fahrurozi
Published: October 2020

The low understanding of the functions of Human Resources management, affects the weak performance of employees. As a result, it has an impact on the wheels of the organization in the Al-Ghufron Pamekasan Foundation. So to find out how much, the effect caused, research needs to be done. This study uses a qualitative descriptive method. As a result, many employees do not understand the HR function. So, it needs to be equipped with education or training on an ongoing basis, in order to improve the quality of work.
PENGARUH KUALITAS LAYANAN, KOMPETENSI & PROMOSI TERHADAP CITRA PROGRAM MAGISTER MANAJEMEN DI MALANG
Authors: Firmansyah Andri , Astutik Widji , Darsono Junianto Tjahjo
Published: October 2020

This study aims to analyze the effect of service quality, competence, and promotion on the image of the Magister of Management Study program in Malang. The method used is quantitive research using a questionnaire research instrument that is distributed to master student in management. The Analysis used is multiple linear regression using SPSS. The results of this study indicate students’ perceptions of service quality, competence, and promotion effect the image of the master’s management study program and promotion becomes the dominant variable affecting the image of the master’s management study program.

Keywords : Image, Service Quality, Competence and Promotion