bluuebunny/crossref_metadata_2025 huggingface dataset:
A Systematic Review of Peer Assessment Design Elements
Authors: Alqassab Maryam , Strijbos Jan-Willem , Panadero Ernesto , Ruiz Javier Fernández , Warrens Matthijs , To Jessica
Published: February 2023

The growing number of peer assessment studies in the last decades created diverse design options for researchers and teachers to implement peer assessment. However, it is still unknown if there are more commonly used peer assessment formats and design elements that could be considered when designing peer assessment activities in educational contexts. This systematic review aims to determine the diversity of peer assessment designs and practices in research studies. A literature search was performed in the electronic databases PsycINFO, PsycARTICLES, Web of Science Core Collection, Medline, ERIC, Academic Search Premier, and EconLit. Using data from 449 research studies (derived from 424 peer-reviewed articles), design differences were investigated for subject domains, assessment purposes, objects, outcomes, and moderators/mediators. Arts and humanities was the most frequent subject domain in the reviewed studies, and two-third of the studies had a formative purpose of assessment. The most used object of assessment was written assessment, and beliefs and perceptions were the most investigated outcomes. Gender topped the list of the investigated moderators/mediators of peer assessment. Latent class analysis of 27 peer assessment design elements revealed a five-class solution reflecting latent patterns that best describe the variability in peer assessment designs (i.e. prototypical peer assessment designs). Only ten design elements significantly contributed to these patterns with an associated effect size R2 ranging from .204 to .880, indicating that peer assessment designs in research studies are not as diverse as they theoretically can be.
Efficacy and safety of catheter ablation as first-line therapy for the management of ventricular tachycardia
Authors: Kotake Yasuhito , Huang Kaimin , Bennett Richard , De Silva Kasun , Bhaskaran Ashwin , Kanawati Juliana , Turnbull Samual , Zhou Julia , Campbell Timothy , Kumar Saurabh
Published: February 2023

Background

Ventricular tachycardia (VT) is associated with significantly increased morbidity and mortality. Catheter ablation (CA) in line with an implantable cardioverter-defibrillator (ICD) is highly effective in VT management; however, it is unknown if CA should be considered as first-line therapy. The aim of this study is to verify the efficacy and safety of CA as first-line therapy for the first VT presentation (as adjunctive to ICD insertion), compared to initial ICD insertion and anti-arrhythmic drug (AAD) therapy.

Methods

Data from patients with the first presentation for VT from January 2017 to January 2021 was reviewed. Patients were classified as “ablation first” vs “ICD first” groups and compared the clinical outcomes between groups.

Results

One hundred and eighty-four consecutive patients presented with VT; 34 underwent CA as first-line therapy prior to ICD insertion, and 150 had ICD insertion/AAD therapy as first‐line. During the median follow-up of 625 days, patients who underwent CA as first-line therapy had significantly higher ventricular arrhythmia (VA)-free survival (91% vs 59%, log-rank P = 0.002) and composite of VA recurrence, cardiovascular hospitalization, transplant, and death (84% vs 54%, log-rank P = 0.01) compared to those who did not undergo CA. Multivariate analysis revealed that first-line CA was the only protective predictor of VA recurrence (hazard ratio (HR) 0.20, P = 0.003). There were 3 (9%) peri-procedural complications with no peri-procedural deaths.

Conclusion

Real-world data supports the efficacy and safety of CA as first-line therapy at the time of the first VT hospitalization, compared to the initial ICD implant and AAD therapy.
Cumulative Lifetime Violence, Gender, Social Determinants of Health and Mental Health in Canadian Men: A Latent Class Analysis
Authors: Scott-Storey Kelly , O’Donnell Sue , Perrin Nancy , Wuest Judith
Published: February 2023

Purpose:

Among men, violence is pervasive and associated with poor mental health, but little is known about which men are most vulnerable. Our purpose is to address this gap by exploring mental health and social determinants of health (SDOH) including gender role conflict (GRC) in heterogenous groups of men with distinct patterns of cumulative lifetime violence (CLV) as target and perpetrator.

Methods:

Latent class analysis was conducted using means of 64 indicators of CLV severity collected from a community sample of 685 eastern Canadian men, ages 19 to 65 years. Class differences by SDOH, and depression, anxiety, and posttraumatic stress disorder (PTSD) were explored with Chi-square and analysis of variance.

Results:

A 4-class solution was optimal. Class 1 had the lowest CLV severity; were more likely to be better educated, employed, and have little difficulty living on their incomes; and had better mental health than other classes. Class 2, characterized by moderate psychological violence as both target and perpetrator, had mean depression and PTSD scores at clinical levels, and more difficulty living on income than Class 1. Classes 3 and 4 were typified by high severity CLV as target but differentiated by Class 4 having the highest perpetration severity, higher GRC, and being older. In both classes, mean mental health scores were above cut-offs for clinical symptomology and higher than Classes 1 and 2.

Conclusion:

This is the first evidence that distinct patterns of CLV severity among men intersect with GRC and SDOH and are uniquely associated with mental health.
MOTEMO-OUTDOOR: ensuring learning and health security during the COVID-19 pandemic through outdoor and online environments in higher education
Authors: Mateo-Canedo Corel , Crespo-Puig Neus , Cladellas Ramon , Méndez-Ulrich Jorge Luis , Sanz Antoni
Published: February 2023

The restriction measures put in place during the COVID-19 pandemic posed notable challenges for formal teaching–learning processes because they had to be adapted to ensure health security. An active learning programme applied to three environments (indoors, outdoors, and online) was tested with 273 undergraduate university students in a within-subjects experimental study. Each student was assigned to two indoor and two outdoor seminars, with a subsample (n = 30) also participating in online seminars implemented in response to the university's lockdown protocols. The learning experience and learning conditions were evaluated through six dimensions: learning, evaluative impact, hedonic experience, technical conditions, environmental conditions, and health security. Outdoor seminars were more effective than indoor seminars in terms of the learning experience, with greater differences in hedonic experience, while the indoor seminars were rated more highly than the outdoor seminars in terms of learning conditions, with a larger difference in the environmental conditions. No differences were found between online and face-to-face environments in terms of the learning experience, even though the online environment yielded better scores in the learning conditions. Apparently, this adaptation to both outdoor and online contexts through active methodologies allows overcoming of technical, environmental, and teaching limitations and improves health security, while ensuring a good learning experience and added flexibility to teaching–learning processes.
Large scale multi-output multi-class classification using Gaussian processes
Authors: Ma Chunchao , Álvarez Mauricio A.
Published: February 2023

Multi-output Gaussian processes (MOGPs) can help to improve predictive performance for some output variables, by leveraging the correlation with other output variables. In this paper, our main motivation is to use multiple-output Gaussian processes to exploit correlations between outputs where each output is a multi-class classification problem. MOGPs have been mostly used for multi-output regression. There are some existing works that use MOGPs for other types of outputs, e.g., multi-output binary classification. However, MOGPs for multi-class classification has been less studied. The reason is twofold: 1) when using a softmax function, it is not clear how to scale it beyond the case of a few outputs; 2) most common type of data in multi-class classification problems consists of image data, and MOGPs are not specifically designed to image data. We thus propose a new MOGPs model called Multi-output Gaussian Processes with Augment & Reduce (MOGPs-AR) that can deal with large scale classification and downsized image input data. Large scale classification is achieved by subsampling both training data sets and classes in each output whereas downsized image input data is handled by incorporating a convolutional kernel into the new model. We show empirically that our proposed model outperforms single-output Gaussian processes in terms of different performance metrics and multi-output Gaussian processes in terms of scalability, both in synthetic and in real classification problems. We include an example with the Ommiglot dataset where we showcase the properties of our model.
Effect of tree species and seed origin on climate change trial outcomes in Southern Ontario
Authors: Pedlar John H. , McKenney Daniel W. , Allen Darren J.
Published: February 2023

Under a changing climate, species will need to rapidly adapt to novel conditions at existing locations, migrate to track suitable climate, or risk widespread declines. For sessile, slow-migrating organisms like trees, adaptive capacity is expected to be particularly important for survival. Alternatively, assisted migration has been proposed as a means to help align tree populations with shifting climate habitats. Here we report on the performance of seed sources and species at broadleaf and conifer climate change trials at 10 and 11 years after planting, respectively. The trials were established in southern Ontario – an important transition zone between boreal and temperate ecosystems – and were designed to assess: (1) the assisted migration potential of six broadleaf species (via northward movements of seed sources), and (2) the adaptive capacity of three conifer species (via southward movements of seed sources). Both broadleaf and coniferous seed sources tolerated significant movements while maintaining reasonable growth and survival rates. In fact, several coniferous seed sources exhibited relatively high growth and survival rates despite southward transfers of more than 1000 km (> 5 °C mean annual temperature) – indicating considerable adaptive capacity to climate change in these northern conifer populations. Furthermore, several of the broadleaf species exhibited high levels of growth and survival despite being planted at, or beyond, their current northern range limits – suggesting the potential for modest range expansions via assisted migration. Despite caveats related to the relatively young age of the plantations and deer browsing at the site, these findings help forest managers better understand potential climate change impacts and assisted migration outcomes.
Carrot genotypes differentially alter soil bacterial communities and decomposition of plant residue in soil
Authors: Triviño Narda J. , Rodriguez-Sanchez Alejandro , Filley Timothy , Camberato James J. , Colley Micaela , Simon Phillip , Hoagland Lori
Published: February 2023

Purpose

Farmers need alternative approaches to manage nitrogen (N) that meet crop needs while reducing loss to the environment. Identifying crop genotypes that promote decomposition of organic materials and understanding the potential mechanisms responsible could help address this challenge. Consequently, we aimed to 1) determine whether carrot genotypes differ in their potential to facilitate organic matter decomposition in soil, and 2) identify bacterial taxa that are stimulated by carrot roots, and thus could play a role in these processes.

Methods

We grew five genotypes expected to differ in N use efficiency in a nutrient-poor soil amended with 15 N-enriched corn residue, tracked changes in carbon (C) and N pools, quantified microbial activity and bacterial community composition, and predicted the potential expression of microbial genes involved in soil C and N cycles.

Results

Experimental genotype 8503 had the greatest capacity to promote decomposition of corn residues. This genotype had the highest % of N from the corn residue in its taproots and on average, promoted higher b-glucosidase activity in soils. Distinct bacterial communities from the families Micromonosporaceae, Chromatiaceae, and Rhodospirillaceae were also enriched in the soils of genotypes like 8503 that were most effective in obtaining N from the corn residue, and this was correlated with greater potential expression of genes responsible for β-glucosidase and nitrification activity.

Conclusions

Carrot genotypes do differ in their potential to alter soil bacterial communities and stimulate microbially-mediated decomposition of organic materials indicating that it may be possible to begin selecting for this important trait.
Prevention Science and Health Equity: A Comprehensive Framework for Preventing Health Inequities and Disparities Associated with Race, Ethnicity, and Social Class
Authors: Biglan Anthony , Prinz Ronald J. , Fishbein Diana
Published: February 2023

The ultimate goal of our public health system is to reduce the incidence of disability and premature death. Evidence suggests that, by this standard, the USA falls behind most other developed countries largely as a function of disparities in health outcomes among significant portions of the US population. We present a framework for addressing these disparities that attributes them, not simply to differences in the behavioral and physical risk factors, but to social, environmental, and structural inequities such as poverty, discrimination, toxic physical setting, and the marketing of harmful products. These inequities result from de facto and instituted public policies. An analysis of the NIH research portfolio indicates a relative lack of investment in experimental evaluations of preventive interventions—especially studies targeting disadvantaged populations. Moreover, experimental research on reducing social inequities is almost entirely lacking. A line of research focusing on the drivers of inequities and their dissolution must include experimental evaluation of strategies for getting policies adopted that will reduce inequities. In conclusion, a summary is provided of the types of research that are needed and the challenges involved in conducting the experimental research that is essential for reducing inequities and disparities and, in turn, prolonging life.
Using Prevention Research to Reduce Racial Disparities in Health Through Innovative Funding Strategies: The Case of Doula Care
Authors: Temple Judy A. , Varshney Nishank
Published: February 2023

Racial disparities in maternal birth outcomes are substantial even when comparing women with similar levels of education. While racial differences in maternal death at birth or shortly afterward have attracted significant attention from researchers, non-fatal but potentially life-threatening pregnancy complications are 30–40 times more common than maternal deaths. Black women have the worst maternal health outcomes. Only recently have health researchers started to view structural racism rather than race as the critical factor underlying these persistent inequities. We discuss the economic framework that prevention scientists can use to convince policymakers to make sustainable investments in maternal health by expanding funding for doula care. While a few states allow Medicaid to fund doula services, most women at risk of poor maternal health outcomes arising from structural racism lack access to culturally sensitive caregivers during the pre-and post-partum periods as well as during birth. We provide a guide to how research in health services can be more readily translated to policy recommendations by describing two innovative ways that cost–benefit analysis can help direct private and public funding to support doula care for Black women and others at risk of poor birth outcomes.
Development of a standard set of PROs and generic PROMs for Dutch medical specialist care
Authors: Oude Voshaar Martijn , Terwee Caroline B. , Haverman Lotte , van der Kolk Bas , Harkes Marleen , van Woerden Christiaan S. , van Breda Fenna , Breukink Stephanie , de Hoop Irma , Vermeulen Hester , de Graaf Evelien , Hazelzet Jan , van Leiden Barbara , Stienen Jozette , Hoekstra Marian , Bart Hans , van Bommel Hester , Determann Domino , Verburg Mariët , van der Wees Philip , Beurskens Anna J.
Published: February 2023

Purpose

The added value of measuring patient-reported outcomes (PROs) for delivering patient-centered care and assessment of healthcare quality is increasingly evident. However, healthcare system wide data collection initiatives are hampered by the proliferation of patient-reported outcome measures (PROMs) and conflicting data collection standards. As part of a national initiative of the Dutch Ministry of Health, Welfare and Sport we developed a consensus-based standard set of generic PROs and PROMs to be implemented across Dutch medical specialist care.

Methods

A working group of mandated representatives of umbrella organizations involved in Dutch medical specialist care, together with PROM experts and patient organizations worked through a structured, consensus-driven co-creation process. This included literature reviews, online expert and working group meetings, and feedback from national patient- and umbrella organizations. The ‘PROM-cycle’ methodology was used to select feasible, valid, and reliable PROMs to obtain domain scores for each of the PROs included in the set.

Results

Eight PROs across different domains of health were ultimately endorsed: symptoms (pain & fatigue), functioning (physical, social/participation, mental [anxiety & depression]), and overarching (quality of life & perceived overall health). A limited number of generic PROMs was endorsed. PROMIS short forms were selected as the preferred instruments for all PROs. Several recommendations were formulated to facilitate healthcare system level adoption and implementation of the standard set.

Conclusions

We developed a consensus-based standard set of Generic PROMs and a set of recommendations to facilitate healthcare system wide implementation across Dutch medical specialist care.
Policy-Development and Deference to Moral Experts
Authors: Elster Jakob
Published: February 2023

The involvement of ethicists, philosophers or others who might qualify as ‘moral experts’ in policy-development, where they are sometimes, typically as members of a committee, given an advisory role, is often seen as problematic, for several reasons. First, there may be doubts as to the very existence of moral experts, and it may be hard to know who the moral experts are. Next, even if these problems are solved, giving experts a special role in policy-making might be problematic from a democratic point of view, if it involves politicians deferring to the moral judgements of experts. The paper considers possible replies to this problem of moral deference. One reply is that moral deference is unnecessary, because even moral non-experts are well equipped to assess the arguments offered by moral experts; I argue that this reply underestimates the complexity of moral arguments. Another reply is that if moral experts are simply given the ‘technical’ role of clarifying which concrete positions that follow from the values which decision-makers already accept, deference is not problematic. I will argue that this reply underestimates how a given set of moral values underdetermines which concrete positions follow from it. Finally, I will consider and defend the reply that since policy decisions are subject to a requirement that they be justified within the limits of public reason, and since these limits include a requirement that the justification be accessible, moral experts are barred from providing policy advice which rests on too complex moral arguments.
EU MECI: A Network-Structured Indicator for a Union of Equality
Authors: Lapatinas Athanasios , Katsaiti Marina-Selini
Published: February 2023

How are the Member States performing in their challenge toward a fairer and more equal Europe? Based on the data measured by the EU Multidimensional Inequality Monitoring Framework (EU MIMF), we introduce the Multidimensional Equality Complexity Index, EU MECI, derived by structuring the EU MIMF data as a bipartite network of countries and indicators. EU MECI is defined upon the economic complexity methodology, exploiting the network’s centrality metrics to calculate aggregate scores of the capacity of Member States to ‘build a Union of equality’.
Simulation comparisons between Bayesian and de-biased estimators in low-rank matrix completion
Authors: Mai The Tien
Published: February 2023

In this paper, we study the low-rank matrix completion problem, a class of machine learning problems, that aims at the prediction of missing entries in a partially observed matrix. Such problems appear in several challenging applications such as collaborative filtering, image processing, and genotype imputation. We compare the Bayesian approaches and a recently introduced de-biased estimator which provides a useful way to build confidence intervals of interest. From a theoretical viewpoint, the de-biased estimator comes with a sharp minimax-optimal rate of estimation error whereas the Bayesian approach reaches this rate with an additional logarithmic factor. Our simulation studies show originally interesting results that the de-biased estimator is just as good as the Bayesian estimators. Moreover, Bayesian approaches are much more stable and can outperform the de-biased estimator in the case of small samples. In addition, we also find that the empirical coverage rate of the confidence intervals obtained by the de-biased estimator for an entry is absolutely lower than of the considered credible interval. These results suggest further theoretical studies on the estimation error and the concentration of Bayesian methods as they are quite limited up to present.
A Balancing Act: How Professionals in the Foster Care System Balance the Harm of Intimate Partner Violence as Compared to the Harm of Child Removal
Authors: Liévano-Karim Laura , Thaxton Taylor , Bobbitt Cecilia , Yee Nicole , Khan Mariam , Franke Todd
Published: February 2023

The striking prevalence of child exposure to intimate partner violence (IPV) and its associated adverse health outcomes necessitates a robust response from professionals who must grapple with the ethical dilemma of how to serve and support children in these circumstances. In 2020, 42 participants from four different professional backgrounds (attorneys, nonprofit leadership, licensed therapists, and social workers) were interviewed or participated in a focus group discussion. All groups acknowledged the shortfalls of current intervention practices, which often result in child removal. Group 1, which included social workers that work for children’s legal services, minor’s counsel, and Los Angeles Department of Child and Family Services social workers, were more conflicted in their recommendations for change. Some Group 1 participants recommended more training, while others thought more training would make little difference and recommended more substantial changes to prevent child removal when possible. Group 2, which included parents’ counsel, and Group 3, which included social workers, attorneys, and nonprofit leadership at IPV nonprofits, were more closely aligned in their recommendations, primarily focusing on systemic changes to the child welfare system. Participants whose employment required them to advocate for parents tend to view child removal from a non-offending parent as harmful for both the child and IPV survivor. These findings illuminate how the perspectives of these diverse participants are influenced by their professional and personal experiences.
How can human values influence work engagement among teachers? an exploratory study
Authors: Coelho Gabriel Lins de Holanda , da Fonsêca Patrícia Nunes , Vilar Roosevelt , de Carvalho Mendes Luis Augusto , Gouveia Valdiney Veloso
Published: February 2023

Human values provide essential insights into how personal characteristics can help build a more positive work environment within an educational context, impacting variables such as organizational commitment and satisfaction with university life. However, it is still unknown to what extent values can help to influence the teachers’ level of work engagement. That is, whether specific values can lead people to present a higher motivation at work. Therefore, we conducted one study (N = 345; Mage = 36.45, SDage = 10.33) to assess teachers’ associations between human values and work engagement. We used the Basic Values Survey and the Utrecht Work Engagement Scale. To evaluate the data, we checked the associations between the variables using Pearson’s correlations and whether human values could significantly predict work engagement using hierarchical regressions. Our results showed that all values significantly correlate to the work engagement dimensions. However, only interactive values (e.g., affectivity, belonging, support), characterized by the motivation to develop and maintain relationships with others, significantly predicted work engagement. Such findings highlight the importance of an environment that allows the development and maintenance of relationships between teachers and their peers and students, favoring a more excellent state of mind towards their work and enhancing their motivation to do their job. We are confident that our research brings novelty to the literature on work engagement, providing the first assessment of human values’ impact on teachers’ motivation towards work.
Application of covalent organic frameworks and metal–organic frameworks nanomaterials in organic/inorganic pollutants removal from solutions through sorption-catalysis strategies
Authors: Chen Zhongshan , Li Yang , Cai Yawen , Wang Suhua , Hu Baowei , Li Bingfeng , Ding Xiaodong , Zhuang Li , Wang Xiangke
Published: February 2023

With the fast development of agriculture, industrialization and urbanization, large amounts of different (in)organic pollutants are inevitably discharged into the ecosystems. The efficient decontamination of the (in)organic contaminants is crucial to human health and ecosystem pollution remediation. Covalent organic frameworks (COFs) and metal–organic frameworks (MOFs) have attracted multidisciplinary research interests because of their outstanding physicochemical properties like high stability, large surface areas, high sorption capacity or catalytic activity. In this review, we summarized the recent works about the elimination/extraction of organic pollutants, heavy metal ions, and radionuclides by MOFs and COFs nanomaterials through the sorption-catalytic degradation for organic chemicals and sorption-catalytic reduction-precipitation-extraction for metals or radionuclides. The interactions between the (in)organic pollutants and COFs/MOFs nanomaterials at the molecular level were discussed from the density functional theory calculation and spectroscopy analysis. The sorption of organic chemicals was mainly dominated by electrostatic attraction, π-π interaction, surface complexation and H-bonding interaction, whereas the sorption of radionuclides and metal ions was mainly attributed to surface complexation, ion exchange, reduction and incorporation reactions. The porous structures, surface functional groups, and active sites were important for the sorption ability and selectivity. The doping or co-doping of metal/nonmetal, or the incorporation with other materials could change the visible light harvest and the generation/separation of electrons/holes (e−/h+) pairs, thereby enhanced the photocatalytic activity. The challenges for the possible application of COFs/MOFs nanomaterials in the elimination of pollutants from water were described in the end.
Agricultural Domestic Support Under the WTO
Authors: Brink Lars , Orden David
Published: February 2023

The WTO Agreement on Agriculture subjects different groups of developed and developing countries to different limits on domestic support and allows various exemptions from these limits. Offering a comprehensive assessment of the Agreement's rules and implementation, this book develops guidance toward socially desirable support policies. Although dispute settlement has clarified interpretation of the Agriculture and SCM Agreements, gaps remain between the legal disciplines and the economic effects of support. Considering the Agriculture Agreement also in the context of today's priorities of sustainability and climate change mitigation, Lars Brink and David Orden build a strategy that aligns the rules and members' commitments with the economic impacts of agricultural support measures. While providing in-depth analysis of the existing rules, their shortcomings and the limited scope of ongoing negotiations, the authors take a long-term view, where policies directed toward evolving priorities in agriculture are compatible with strengthened rules that reduce trade and production distortions.
Madama Butterfly/Madamu Batafurai
Authors: Groos Arthur
Published: February 2023

Puccini's famous but controversial Madama Butterfly reflects a practice of 'temporary marriage' between Western men and Japanese women in nineteenth-century treaty ports. Groos' book identifies the plot's origin in an eye-witness account and traces its transmission via John Luther Long's short story and David Belasco's play. Archival sources, many unpublished, reveal how Puccini and his librettists imbued the opera with differing constructions of the action and its heroine. Groos's analysis suggests how they constructed a 'contemporary' music-drama with multiple possibilities for interpreting the misalliance between a callous American naval officer and an impoverished fifteen-year-old geisha, providing a more complex understanding of the heroine's presumed 'marriage'. As an orientalizing tragedy with a racially inflected representation of Cio-Cio-San, the opera became a lightning rod for identity politics in Japan, while also stimulating decolonizing transpositions into indigenous theatre traditions such as Bunraku puppet theatre and Takarazuka musicals.
Particle transport in a turbulent pipe flow: direct numerical simulations, phenomenological modelling and physical mechanisms
Authors: Zahtila T. , Chan L. , Ooi A. , Philip J.
Published: February 2023

In particle-laden turbulent wall flows, transport of particles towards solid walls is phenomenologically thought to be governed by the wall-normal turbulence intensity supporting the underlying particle–eddy interactions that are usually modelled by a combination of turbophoresis and turbulent diffusion. We estimate the turbophoretic and turbulent diffusive coefficients as a function of wall-normal coordinate directly from a generated direct numerical simulation (DNS) database of low volume fraction point particles in a turbulent pipe flow. These coefficients are then used in an advection–diffusion equation to estimate the particle concentration as a function of wall-normal distance and time, with favourable comparison against DNS for smaller Stokes number (

$St^+$

) particles suggesting a limitation of the common gradient diffusion hypothesis for larger

$St^+$

particles. Using DNS we explore the non-trivial effects of

$St^+$

, pipe wall condition (particle absorbing or elastic) as well as the influence of drag and lift force on the velocity and particle statistics giving rise to different particle concentrations. We then appraise various Eulerian-based models of turbophoretic and turbulent diffusive coefficients and, finally, use physical insights from Lagrangian correlation times, conditional quadrant analysis and flow topology to shed further light on the particle transport as a function of various parameters and the limits of gradient diffusion hypothesis.
Vitamin D: determinants of status, indications for testing and knowledge in a convenience sample of Irish adults
Authors: Scully Helena , Laird Eamon J. , Healy Martin , Crowley Vivion , Walsh James Bernard , McCarroll Kevin
Published: February 2023

Vitamin D deficiency is common in Irish adults, though there is limited research on its determinants, knowledge of vitamin D or indications for testing. We aimed to explore the determinants of vitamin D status in adults and examine knowledge and reasons for testing. The study population comprised adults who had serum 25-hydroxyvitamin D tested by general practitioners request at a Dublin Hospital in 2020. Questionnaires detailing dietary intake, sun exposure, ethnicity, biophysical factors and vitamin D knowledge were sent to a sample stratified by age, sex and vitamin D status. In total, there were 383 participants, mean age 56·0 (sd 16·6) years. Wintertime deficiency disproportionally affected non-white v. white (60 % v. 24 %, P < 0·001). The greatest predictors of deficiency were low vitamin D intake (< 10 μg/d) (P < 0·001) and non-white ethnicity (P = 0·006), followed by sun avoidance (P = 0·022). It was also more prevalent in those with lower body exposure when outdoors. The majority (86 %) identified vitamin D as important for bone health. However, 40 % were tested for non-clinical indications and half were not aware of the recommended daily allowance (RDA). Low vitamin D intake was the most important determinant of deficiency, but ethnicity and sun exposure habits were also significant predictors. The majority had no clear indication for testing and were not aware of the RDA. Public health policies to improve knowledge and vitamin D intake, especially for those of non-white ethnicity and with reduced sun exposure, should be considered.
Jonasian Gnosticism
Authors: Sariel Aviram
Published: February 2023

This article proposes that Jonas’s understanding of gnosticism differs substantially from the account typically associated with him. That standard account takes the basic tenets of existentialism as the foundation to its discussion of alienated individuality, whereas Jonas’s system uses neo-Kantian epistemology to construct both alienation and individuality out of a unified field of human interaction. Within his framework, gnosticism is a single historical-philosophical episode of inauthenticity, highly influential yet isolated in time, unlike the ubiquitous understanding of it. This article reviews Jonas’s system, elements of its early and later acceptance, along with selected issues raised by critics, from Heidegger and Scholem to Colpe, Yamauchi, Williams, and King.
How Jewish Orthodoxy Became a State: Isaac Breuer and the Invention of the Statist Theocracy
Authors: Ben Ami Itamar
Published: February 2023

This article traces the incorporation of the modern state and the notion of sovereignty into Jewish Orthodox thought, culminating in the idea that the role of Orthodoxy is to establish a statist theocracy. Unlike narratives that emphasize the continuation of theocratic thought from ancient to modern Judaism on the one hand, and the relationship between religious Zionism and contemporary forms of Jewish theocracy on the other, my research reveals a fundamentally anti-Zionist, ultra-Orthodox layer in the doctrine of statist theocracy, through a novel reading of the early writings of one of the leaders of Agudath Israel, Isaac Breuer (1883–1946). During the 1920s, Breuer coined terms such as Gottesstaat and Torastaat, which informed broader theocratic discussions into the 1930s. The article examines the intellectual history of this discourse and the grammar of this doctrine, identifying in it ultra-Orthodox reasoning such as an aversion to secularism and modern nationalism, resistance to a redemptive, kookian philosophy of history, and adherence to the “Rule of Torah.”
Evolution and emergence of mosquito-borne viruses of medical importance: towards a routine metagenomic surveillance approach
Authors: Laiton-Donato Katherine , Guzmán-Cardozo Camila , Peláez-Carvajal Dioselina , Ajami Nadim J. , Navas María-Cristina , Parra-Henao Gabriel , Usme-Ciro José A.
Published: February 2023

During the last two decades, the world has witnessed the emergence and re-emergence of arthropod-borne viruses, better known as arboviruses. The close contact between sylvatic, rural and peri-urban vector species and humans has been mainly determined by the environment-modifying human activity. The resulting interactions have led to multiple dead-end host infections and have allowed sylvatic arboviruses to eventually adapt to new vectors and hosts, contributing to the establishment of urban transmission cycles of some viruses with enormous epidemiologic impact. The metagenomic next-generation sequencing (NGS) approach has allowed obtaining unbiased sequence information of millions of DNA and RNA molecules from clinical and environmental samples. Robust bioinformatics tools have enabled the assembly of individual sequence reads into contigs and scaffolds partially or completely representing the genomes of the microorganisms and viruses being present in biological samples of clinical relevance. In this review, we describe the different ecological scenarios for the emergence of viral diseases, the virus adaptation process required for the establishment of a new transmission cycle and the usefulness of NGS and computational methods for the discovery and routine genomic surveillance of mosquito-borne viruses in their ecosystems.
Non-deep simple and deep simple morphophysiological dormancy in seeds of three species of Ilex from subtropical and tropical regions of Taiwan
Authors: Liu Chiung-Pin , Chen Shun-Ying , Baskin Carol C. , Chien Ching-Te
Published: February 2023

Dormancy-breaking requirements and level of morphophysiological dormancy (MPD) were determined for seeds of Ilex formosana and I. uraiensis from the subtropical region, and seeds of I. rotunda from both the subtropical and tropical regions of Taiwan. We hypothesized that some Ilex species would have deep simple MPD broken by warm stratification. Germination of seeds and embryo growth was monitored at 30/20, 25/15, 20/10, 15/5°C and at 25°C. Seeds were cold-stratified and then incubated at 25/15°C, and seeds treated with GA3 and GA4 were incubated at 25/15°C. Fresh seeds reached 50% germination after 11–45 weeks of warm stratification. Pre-treatment with GA increased germination percentages of I. formosana and I. rotunda (tropical) but not I. uraiensis and I. rotunda (subtropical), while cold stratification did not promote germination of either species but increased the germination rate of I. rotunda (tropical). Embryo length in seeds of all species increased ≥710% prior to root emergence, and growth occurred during warm stratification. The positive response to GA and relatively short time for beginning of germination and to reach 50% germination indicate non-deep simple MPD in seeds of I. formosana and I. rotunda (tropical). The negative response to GA and long time for beginning of germination and to reach 50% germination indicate deep simple MPD in seeds of I. uraiensis and I. rotunda (subtropical). Thus, in both the subtropical and tropical regions of Taiwan, the seeds of Ilex species have non-deep simple and deep simple MPD that are broken by warm stratification. Furthermore, GA treatment increases the germination rate and percentage of Ilex seeds with non-deep simple MPD, and cold stratification promotes the seed germination rate of Ilex species with non-deep simple MPD in tropical region.
Does neurocognition contribute to age-related deficits in the online navigation of electronic patient health portals?
Authors: Matchanova Anastasia , Babicz Michelle A. , Kordovski Victoria M. , Tierney Savanna M. , Rahman Samina , Medina Luis D. , Cushman Clint , Woods Steven Paul
Published: February 2023

Objective:

The internet serves an increasingly critical role in how older adults manage their personal health. Electronic patient portals, for example, provide a centralized platform for older adults to access lab results, manage prescriptions and appointments, and communicate with providers. This study examined whether neurocognition mediates the effect of older age on electronic patient portal navigation.

Method:

Forty-nine younger (18–35 years) and 35 older adults (50–75 years) completed the Test of Online Health Records Navigation (TOHRN), which is an experimenter-controlled website on which participants were asked to log-in, review laboratory results, read provider messages, and schedule an appointment. Participants also completed a neuropsychological battery, self-report questionnaires, and measures of health literacy and functional capacity.

Results:

Mediation analyses revealed a significant indirect effect of older age on lower TOHRN accuracy, which was fully mediated by the total cognitive composite.

Conclusions:

Findings indicate that neurocognition may help explain some of the variance in age-related difficulties navigating electronic patient health portals. Future studies might examine the possible benefits of both structural (e.g., human factors web design enhancement) and individual (e.g., training and compensation) cognitive supports to improve the navigability of electronic patient health portals for older adults.
Associations between sugar-sweetened beverages before and during pregnancy and offspring overweight/obesity in Japanese women: the TMM BirThree Cohort Study
Authors: Aizawa Misato , Murakami Keiko , Yonezawa Yudai , Takahashi Ippei , Onuma Tomomi , Noda Aoi , Ueno Fumihiko , Matsuzaki Fumiko , Ishikuro Mami , Obara Taku , Kuriyama Shinichi
Published: February 2023

Objective:

The association between high sugar-sweetened beverages (SSB) intake during pregnancy and offspring overweight/obesity has been reported only from Western countries. The objective of this study was to examine the association between SSB intake before and during pregnancy and offspring overweight/obesity among Japanese women.

Design:

Japanese prospective birth cohort study.

Setting:

We analysed mother–offspring pairs who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study from 2013 to 2017. SSB intake during pregnancy was evaluated using the FFQ and classified into three groups: none (0 g/d), medium (<195 g/d) and high (>195 g/d). Overweight or obesity at 1 year of age in offspring was defined as having a BMI Z-score greater than 2 sd, calculated based on the BMI reference data for Japanese children. Multiple logistic regression analyses were performed to examine the associations between SSB intake before and during pregnancy and offspring overweight/obesity, after adjusting for covariates.

Participants:

Japanese mother–offspring pairs (n 7114).

Results:

The overweight/obesity rate of the offspring was 8·8 %. Pregnant women with a high intake of SSB in early to mid-pregnancy had a higher risk of overweight/obesity in their offspring compared with those who did not; the OR was 1·52 (95 % CI (1·09, 2·12)).

Conclusions:

High SSB intake in early to mid-pregnancy was associated with an increased risk of offspring overweight/obesity at 1 year of age.
Developing and creating didactic proposals for Latin and Classical Culture Training course with the educational centre CEFIRE
Authors: Regagliolo Alberto
Published: February 2023

The aim of this paper is to set out the results of the Developing and creating didactic proposals for Latin and Classical Culture (now DPLCC) course, which was financed and organised with the Spanish Ministry of Education, CEFIRE, during 2021.

The training programme is aimed at teachers and anyone qualified to teach classical languages. It has been divided into two parts: a theory and a practical section. The theory section entailed a review of some fundamental topics in language teaching. The practical section involved the creation of a didactic proposal based on the element of water. The course counted a total of 34 participants; only 22 finished the theory section and 12 the practical section. From a practical perspective for participants, it was observed that various activities were effectively carried out. In particular, the trainees produced quality texts adapted to the required level. In addition, the proposed exercises are diverse and appropriate for the planned objectives. On the other hand, the graphic design, page layout and illustrations proposed did not have a particular focus on quality, indicating a lesser degree of technical and graphic preparation for producing materials that are also visually appealing to a younger audience. The study shows that trainees revisit and create new activities from scratch, always staying aligned with the chosen theme and the proposed educational level.
Toward a Catchment‐Scale Assessment of Flood Peak Attenuation by Multiple Reservoirs
Authors: Cipollini S. , Volpi E. , Fiori A.
Published: February 2023

The estimation of reservoirs impact on flood peak reduction at the catchment scale is of fundamental importance for risk assessment and planning purposes. It is generally addressed using detailed hydrologic‐hydrodynamic simulations or simple, empirically based indices. The former provide detailed results, at the cost of a large amount of information and high computational efforts; the latter are cost‐effective and simple, yet they generally provide approximate results. A promising compromise between the two is the physically based attenuation index , based on the concept of equivalent reservoir; was recently proposed in the literature to estimate the impact of multiple reservoirs located in series along the main channel, based on the assumption of rectangular catchment. In this work, we extend the equivalent reservoir approach to a generic catchment, with any shape and without restrictions on the location of the reservoirs. For an effective assessment of the method, we also introduce the novel concept of Reservoir‐influenced Instantaneous Unit Hydrograph (RIUH); the RIUH can be derived using a Monte Carlo procedure to include the effects of reservoirs on the Instantaneous Unit Hydrograph. Simulations of numerous fictitious reservoir configurations in a real basin demonstrate the potential of the methods in reproducing the attenuation effect. Remarkably, an average error of 3%–5% exists between and the peak reduction of a less simplified reality (RIUH). Finally, we provide a global, catchment‐scale application of the attenuation index, which constitutes an effective tool for the evaluation of each reservoir in managed catchment system and the design or planning of new hydraulic infrastructures.
The oncogenic roles and clinical implications of YAP/TAZ in breast cancer
Authors: Luo Juan , Zou Hailin , Guo Yibo , Tong Tongyu , Chen Yun , Xiao Yunjun , Pan Yihang , Li Peng
Published: February 2023

Breast cancer (BC) is the most commonly diagnosed form of cancer and a leading cause of cancer-related deaths among women worldwide. Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are homologous transcriptional coactivators and downstream effectors of Hippo signalling. YAP/TAZ activation has been revealed to play essential roles in multiple events of BC development, including tumour initiation, progression, metastasis, drug resistance and stemness regulations. In this review, we will first give an overview of YAP/TAZ-mediated oncogenesis in BC, and then systematically summarise the oncogenic roles of YAP/TAZ in various BC subtypes, BC stem cells (BCSCs) and tumour microenvironments (TMEs). Based on these findings, we will further discuss the clinical implications of YAP/TAZ-based targeted therapies in BC and the potential future direction.