bluuebunny/crossref_metadata_2025 huggingface dataset:
Future Time Perception and Examination of Depression Terms of Hope
Authors:   Sakarya University, Turkey, Çetin Fatma , Kaya Mehmet
Published: May 2021

The aim of this study is to examine the depression levels of university students according to their perception of future time and hope. The research is a relational screening study and it was conducted with the participation of 1st and 4th year undergraduate students studying in various departments of different universities (n = 368). The data of the study were collected using the Future Time Perception Scale (FTPS), the Trait Hope Scale (THS) and the Beck Depression Inventory (BDI). In the analysis of the data according to the research questions; independent sample t test, correlation analysis and multiple regression analysis were used. The data of the research were analyzed with the SPSS 24.0 package program. As a result of the research, weakly significant relationships were found between future time perception scores and hope scores, while moderate and high negative significant relationships were found between hope and depression scores. According to another result of the study, when the perceptions of future time and hope levels of 1st and 4th grade students were examined to predict depression, it was concluded that while future time perception was not a predictor of depression, hope scores predicted depression. According to the results of the research, when the future time perception, hope and depression levels were compared, it was found that the future time perception and commitment scores of the 1st grade students were higher than the 4th grade students.
Training and Development Practices and Employees’ Performance in Selected Manufacturing Companies in Nigeria
Authors: Taiwo, Sunday F.  , Dr. Alase, Peter O.  , Dr. Hassan, Tolani, A.  , Okusanya, Adedoyin, O.
Published: May 2021

Managing workforce diversity in manufacturing organisations has been a problem all over the world including Nigeria. Manufacturing organisations in Nigeria continue to experience occasional drop in performance due to employees’ apathy and non-challant attitudes as a result of high level of dissatisfaction caused by inadequate attention to training and development practices. This study assessed the relationships between training and development practices and employees’ performance in selected manufacturing companies in Nigeria. A cross sectional survey research design was employed, and out of the 1,568 copies of questionnaire that were administered proportionally in the selected manufacturing companies, 1,153 copies were retrieved and found useful. Data were analysed using descriptive statistics and the hypotheses were tested using Analysis of Variance (ANOVA). The results of the findings show f-statistics of 223.717 and so, there is a significant relationship between training and development practices and employees’ performance among Nigerians working in the selected manufacturing companies. Also, f-statistics of 244.391 shows a significant relationship between training and development practices and employees’ performance among other nationals in the selected MNCs. The study concluded that there are significant relationships between training and development practices and employees’ performance in selected manufacturing MNCs in Nigeria.
Effects of the Covid- 19 Pandemic and its Attendant Lockdown Policy on the Economy of Plateau State
Authors: Dr. Yohanna Gyang Jugu  , Dr. Mary Ada Ogenyi  , Tosin D. Bodunde  , Dr. Abubakar Saidu
Published: May 2021

The Continuous Decline In Revenue Base Of The Nation Has Remain A Matter Of Serious Concern Among Researchers And Government, Due To Challenges Arisen From The Covid – 19 Pandemic. In The Light Of This, The Study Was Set Out To Empirically Examine The Effects Of Covid – 19 Lockdown On The Internally Generated Revenue Of Plateau State. To Achieve This Objective, Systematic Review And Meta-Analysis, Combined With An Exploratory Research Design Approach Were Employed And Adopted By The Researchers, And A Sample Of 76 Respondents Was Taken From The Population Of Staff Of The Plateau State Internal Revenue Service With Specific Focus On Those That Are Directly Responsible For The Collection Of Taxes. To Analyse The Data, Both Independent T – Test And Logit Binary Regression Model Were Used To Test The Hypotheses Of This Study. Arisen From The Analysis, The Study Revealed That: There Is Significant Difference Between Revenue Generated Before And During Covid-19 Lockdown In Plateau State; And Covid - 19 Lockdown Has Significant Adverse Effect On Internally Generated Revenue (Igr). Based On The Findings, The Following Recommendations Were Made: Government Of Plateau State Should Ensure That Business Activities Are Continuing Through Digitalised System And That The Government Should Link Tax Identification Numbers (Tin) To Online Business Activities So As To Guarantee Continued Internally Revenue Generation For The State; Government Should Train Their Staff On The Use Of Ict, Especially In The Area Of Revenue Collection; And Staff Of Ministries, Departments And Agencies (Mdas) Should Ensure That Sharp And Dubious Practices Are Properly Checked To Allow For The Free Flow Of Ict System In Revenue Collection.
Challenges and Experiences of Students in the Virtual Classroom World: A Literature Review
Authors: Bhavika Pandita Hakhroo
Published: May 2021

The study aims to discuss the experience students face in the virtual classroom mode. The limitations and challenges which students face while enrolling in online modes to learning from MOOC Courses to Distance Learning. The community of the people undertaking online education has increased significantly in the past few years. The paper reviews the literature on the topic of online classes, asynchronous and synchronous modes of delivery, the perception of students in the virtual learning and the experiences and challenges faced.
Management Information System - Human Resource & Payroll System for Sri Lanka Ports Authority
Authors: K J Lokugama
Published: May 2021

Payroll is the one of most critical process in every large organization; it has many functionalities to fulfill on time for a smooth payroll process. When the number of employees varies on time to time due to retirements and new appointments and calculation method differs based on it, increases the complication of the system. Management operations concerning data can be a complicated scenario when the amount of data involved is large. More importantly, when the data involved requires a high level of accuracy, then the management role becomes hectic. Payroll is a sector of the management in which accuracy is required and a lapse in the data can lead to adverse effect on employee motivation and production. In such system, cost estimation is very vital for top management proceed with future organizational plans.
In Vitro Micropropagation of Lilium candidum Bulb by Application of Multiple Hormone Concentrations Using Plant Tissue Culture Technique
Authors: Akshay Milind Patil  , Pooja Prakash Gunjal  , Dr. Sonali Das
Published: May 2021

The multiplication efficacy by bulb is low and the plantlets are more susceptible to disease, therefore, there is a need to develop a protocol for its propagation. Lilium candidum is listed in the saitma prefecture Red Data Book as a critically endangered plant and rescuing information regarding its micro-propagation is rather limited. On this regard, the application of in vitro micropropagtion procedure might help to obtain large numbers of uniform plants of endangered species of Lilium. Dried lilies are a rich source of fiber and also rich in sodium and carbs. Lily bulbs have proteins and starch and also small quantities of iron, calcium, phosphorous, and vitamin B1, B2, C. The health benefits of the lily for the heart are well known on account of the active cardiac glycosides as well as the flavonoids which tend to stimulate the arteries and can cause them to dilute. Another one of the therapeutic uses of the lily flower is in the case of treating burns and preventing the formation of scar tissue. One of the main health benefits of the lily flower is that it helps regulating the heart rate there by allowing the heart to function more efficiently and regular. Having multiple medicinal properties we decided to cultivate Lilium candidum using plant tissue culture so farming can be increased using this cost efficient techniques. In this research, we have studied various Effect of different concentration of BAP and NAA on the initiation of Lilium candidum from bulb and IBA, IAA and NAA on the rooting of shoots of Lilium Candidum.
A Pilot Study of Six Factors Composite Physical Fitness Test on School Going Boys
Authors: Mr. Abhinav Kushwaha  , Dr. Dharmender Kumar  , Dr. Meenakshi
Published: May 2021

Objective of study was to assess data the six factors composite physical fitness test on school going boy’s students.

Methods for the study, 100 boys were randomly selected from govt. school of Delhi govt. at age ranging from 15 to 18 years.  The study was conducted by using six factors composite physical test. Descriptive statistics was employed to find out the results of the study.  Physical fitness was measured with the best timing was rated in seconds.

Results the result depicted in Descriptive Statistics of boys at school level” indicates the mean, confidence interval, skewness, kurtosis, range and standard deviation. The lower bound shows the true significance and significance correction and through Q-Q plot the (graphical presentation) to values in normal distribution to evident in found the selected physical fitness test for 100 school going boys were Mean- 40.3072/39.0291, Std. Deviation-2.51278/2.78882, Std. Error Mean- 2.5128/2.7888 respectively. That paired correlation is .56. There is an average value of test score and Significant at 0.05 level of significance. The Table no.-5 to indicate paired differences of variable being tested and order the subtraction was found out. The standard error 0.24799 and computing both the test statistic and the upper and lower bounds of 95%confidence interval. The depicts value of the paired sample t- test of boys which was found to be statistically significantly at 0.05 level of significance.

Objective of study was to assess data the six factors composite physical fitness test on school going boy’s students.

Methods for the study, 100 boys were randomly selected from govt. school of Delhi govt. at age ranging from 15 to 18 years.  The study was conducted by using six factors composite physical test. Descriptive statistics was employed to find out the results of the study.  Physical fitness was measured with the best timing was rated in seconds.

Results the result depicted in Descriptive Statistics of boys at school level” indicates the mean, confidence interval, skewness, kurtosis, range and standard deviation. The lower bound shows the true significance and significance correction and through Q-Q plot the (graphical presentation) to values in normal distribution to evident in found the selected physical fitness test for 100 school going boys were Mean- 40.3072/39.0291, Std. Deviation-2.51278/2.78882, Std. Error Mean- 2.5128/2.7888 respectively. That paired correlation is .56. There is an average value of test score and Significant at 0.05 level of significance. The Table no.-5 to indicate paired differences of variable being tested and order the subtraction was found out. The standard error 0.24799 and computing both the test statistic and the upper and lower bounds of 95%confidence interval. The depicts value of the paired sample t- test of boys which was found to be statistically significantly at 0.05 level of significance.
Risk Assessment of Heavy Metal Fe, Mn, Zn and Cu Intake by Consuming Herbal Tea Thyme
Authors: Nisveta Softić  , Halid Makić  , Edisa Trumić  , Husejin Keran  , Melisa Ahmetović
Published: May 2021

One of the most important public- health tasks is to provide hygienic and healthy food and water, which will not have harmful consequences for the health of consumers, and in this way a safe food trade is ensured, therefore protecting everyone in the chain from the producer to the consumer. This paper presents the concentrations of heavy metals Fe, Mn, Zn and Cu, obtained by atomic absorption spectrophotometry (AAS), from 5 samples of thyme infusion (lat. Thymus serpyllum), which can be found on the market of Travnik. Sample infusions were prepared by holding the filter bags in boiling deionized water for 10 minutes. Mean values of concentrations of these heavy metals were for Fe 0.0508 ± 0.0139 mg/kg, Mn 0.06 ± 0.0069 mg/kg, Zn 0.0436 ± 0.0147 mg/kg, while the Cu content was not detected in any infusion of the said tea. The risk assessment of the intake of tested heavy metals for the health of consumers, expressed through the Hazard Index (HI), which was <1, shows that the samples of analyzed teas are safe for consumption.
Intronic SNPs and Genetic Diseases: A Review
Authors: Maan Hasan Salih  , Adnan F Al-Azzawie  , Akeel Hussain Ali Al-Assie
Published: May 2021

Introns qualify as Noncoding nucleotide sequences. In splicing, some segments of the RNA transcript (introns) are eliminated, the other segments (exons) are joining together in the formation of the coding RNAs (mRNA, rRNA and tRNA). Also, Non-coding RNA genes are parts of the intronic. On average, there are 7.8 introns and 8.8 exons per human gene. Single nucleotide polymorphisms (SNPs) are existed in the various positions through the human gene, promoters, alternating regions of exons and introns, terminator, in addition to UTRs, untranslated regions (5'- and 3'-).Therefore, many diseases have been associated with SNPs through different mechanisms. In the current review, we will discuss the several genetic and epigenetic regulations included in identifying disease susceptibility linked to numerous SNPs existing in the intronic region.
Incidence of iron deficiency and its pathogenesis in patients with H. pylori infection
Authors: Shulyat’Eva N. V. , Drozdov V. N. , Shikh E. V.
Published: May 2021

606 patients (405 men and 201 women) with HP infection were examined, 121 (m 67; f 54) found clinical or clinical and laboratory signs of iron deficiency, the frequency of iron deficiency in the examined group of patients with HP was 19.9% (16.8-23.3; CI 95%). 25 (20.7%) were diagnosed with anaemia, 66 (54.5%) patients had a latent deficit of iron, 30 patients (24.8%) showed only a decrease in TS, which is typical for pre-latent iron deficiency. 38 (31.4%) patients had a «true» iron deficiency, 44 (36.4%) patients had a combined variant of iron deficiency, and 39 (32.2%) iron deficiency developed as a result of chronic inflammation. There was a significant difference in the level of hepcidin in patients with different options for iron deficiency. In patients with “isolated” iron deficiency, it was 12.4 ± 2.3 ng/ml, vs 48.2-± 20.2 ng/ml vs 189.7 ± 31.1 ng / ml in patients with a combined pathogenic variant of iron deficiency and in patients with iron deficiency of chronic inflammation, respectively.
Predicting of fentanyl-associated neurotoxicity in pancreatic cancer with clical, genetic model
Authors: Bobrova O. P. , Shnayder N. A. , Petrova M. M. , Zobova S. N. , Dykhno Yu. A. , Zyryanov S. K. , Bobrov A. V. , Nasyrova R. F. , Lipinskiy L. V. , Polyakova A. S. , Melnikova O. D.
Published: May 2021

Aim. To develop a model for the implementation of opioid - associated neurotoxicity in patients with pancreatic cancer based on an analysis of the relationship of clinical and genetic factors. Materials and methods. In 45 patients with pancreatic cancer, 54 clinical and genetic factors were studied for predicting the implementation of opioid-associated neurotoxicity, receiving a transdermal form of fentanyl. Results. A clinical genetic model of the implementation of opioid - associated neurotoxicity in patients with pancreatic cancer was developed using the example of a transdermal form of fentanyl Conclusion. The clinical genetic model for predicting the risk of opioid-associated neurotoxicity in patients with pancreatic cancer is important from the perspective of personalized medicine.
Motor function of the gastrointestinal tract in gastric erosions
Authors: Lychkova A. E. , Khomeriki S. G. , Puzikov A. M.
Published: May 2021

The aim is to study motor disorders of the gastrointestinal tract and biliary tract with erosion of the stomach. Materials and methods. Electromyography (EMG) of the gastrointestinal tract and biliary tract was performed in 35 patients with gastric erosions; the control group consisted of 10 patients with gastric ulcer. A morphological study of biopsies of the antrum of the stomach was carried out. Results. Patients with erosion of the stomach were characterized by severe hypermotor dyskinesia of the stomach with a decrease in the motor function of the small intestine and multidirectional changes in the motor function of the colon. Motility of the biliary tract is characterized by an increase in tonic activity with a slight increase in phase activity. Histological examination revealed areas of fibrinoid necrosis in its own plate and foci of destruction of the end sections of the pyloric glands. Conclusion. Motor function of patients with gastric erosion is characterized by a greater power of muscle contractions of the stomach, a smaller power of muscle contractions of the small intestine and multidirectional changes of the power contractions of various sections of the colon.
Comparative Evaluation of Hepatoprotective Activities of Trigonella foenum-graecum (seeds), Cymbopogon proximus and Acacia nilotica on a model of acute carbon tetrachloride hepatitis in rats
Authors: Mutawakel Abbas Abdelhamid , Inchina V. I. , Tarasova T. V. , Varvanina G. G. , Trubitsyna I. E.
Published: May 2021

An experimental study of the beneficial effect of herbal preparations on acute toxic liver damage with carbon tetrachloride (CCl4) in animals was conducted The goal is to Compare the hepatoprotective effect of three water extracts of herbal preparations: (I) Trigonella foenum-graecum (seeds), (II) Cymbopogon proximus, (III) Asasia nilotica Material and methods. To simulate acute toxic liver damage, 50% CCl4 was administered once intraperitonally in doses of 0.6 ml, 0.3 ml, and 0.2 ml. Control groups: K1-1 group intact animals without injections; K2: groups 2, 3, 4. introduced saline solution (FR) without Ssl4 in the volume of 2 ml. Experimental groups: 5, 6, 7 and 8 studied the hepatoprotective properties of aqueous solutions of the studied drugs after intraperitoneal administration of Ssl4 or FR. Researched herbs: I, II, III, in different doses were administered 2 ml of an aqueous solution in breeding 1:10, observation period 5 days, the blood, for research stabilized solution of sodium citrate in the ratio of 1:10, studied the properties of blood cells hematological analyzer PCE-90Vet (USA). The content of total protein, albumin, total cholesterol, triglycerides, urea, creatinine and transaminase activity - ALT, AST-were recorded in the blood serum using an automatic analyzer of the company “ HUMASTAR 600 “(Germany)», Results and discussion. Water extracts of preparations I and II prevented the reduction of red blood cells and platelets, and activated the macrophage pool. All the herb extracts studied prevent platelet reduction, however, but do not bring them up to the indicators of intact animals. The use of solution III prevented the growth of the cytolysis enzyme-ALT. All studied extracts in acute carbon tetrachloride intoxication. they warned of an increase in hypertriglyceremia. The introduction of water extracts II, III in the 1:10 ratio prevented the development of necrotic changes in hepatocytes, inflammatory infiltration, manifestations of fatty dystrophy, and preserved the architectonics of the liver lobule.
Liver damage while Covid-19: problems of pathogenesis and treatment
Authors: Lyalyukova E. A. , Dolgalev I. V. , Chernysheva E. N. , Druk I. V. , Konovalova G. M. , Lyalyukov A. V.
Published: May 2021

The purpose of the review is to present an analysis of the current literature data on the pathogenesis and therapy of liver damage in Covid-19. Liver damage in COVID-19 patients can be caused by the direct cytopathogenic effect of SARS-CoV-2, an uncontrolled immune response, sepsis, severe hypoxia, or drug damage. In addition, COVID-19 can exacerbate and decompensate previously formed chronic liver diseases with the development of acute liver failure. Physicians should carefully assess the initial state of the liver, and after prescribing therapy, intensify monitoring of its functional state, especially in patients with severe COVID-19. In each clinical case, the doctor needs to establish the possible mechanisms of organ damage in order to select the most optimal patient management tactics, which would take into account all aspects of the COVID-19 course and liver damage. Currently, additional scientific information is required to uncover the features of liver damage during SARS-CoV-2 infection and in the postcovid period. Patients who have undergone COVID-19 need further monitoring to assess the long-term effects of the disease.
Early arthritis and digestive diseases. A rheumatologist’s view
Authors: Galushko E. A. , Gordeev A. V. , Lila A. M.
Published: May 2021

Peripheral arthritis is one of the most common manifestations of articular syndrome, not always associated with rheumatic diseases. Determination of its nosological affiliation and rational therapy at an early stage (early arthritis) present a complex clinical and diagnostic problem requiring an interdisciplinary approach. The review presents the differential diagnosis of early arthritis in diseases of the gastrointestinal tract such as inflammatory bowel disease, celiac disease, PPP syndrome (Pancreatitis, panniculitis and polyarthritis (PPP-) syndrome), etc., manifested by similar clinical symptoms with rheumatic diseases such as early rheumatoid arthritis and spondylitis. Most of the immuno-inflammatory diseases presented in the review are multisystemic and heterogeneous in clinical symptoms, course and outcomes. Therefore, the diagnostic process, especially in case of early arthritis with typical multisystem involvement, is comprehensive and cognitive in nature and requires the synthesis of many data that are usually not taken into account in a simple algorithm based on a set of classification criteria.
“Old” and “new” probiotics in the treatment of gastroenterological diseases in children and adults: how to increase effectiveness?
Authors: Gonchar N. V. , Alexina G. G. , Suvorov A. N.
Published: May 2021

The purpose of the review is to analyze the real benefits of the use of traditional probiotics and to highlight the issues of the possibility of creating and using new generation probiotics in the treatment of gastroenterological pathology. Questions of effectiveness of therapy with traditional probiotics of functional and organic diseases of the gastrointestinal tract in children and adults from the points of view of evidence-based medicine are analyzed, insufficient number of studies in children and frequent absence of significant differences in the effect of probiotics compared to placebo are emphasized. New generation probiotic candidates are described, which could become potential sources of new drugs for various diseases, including gastroenterological pathology. The main problems in the way of creation and introduction of new probiotics are outlined. Data on an alternative approach of probiotic therapy based on use to restore microbiocenosis of own bacteria, which are grown as pure genetically characterized cultures and can be used as probiotic products, are presented.
Difficulties of multidisciplinary diagnostics of indeterminate colitis
Authors: Dubrova S. E. , Lunina S. M. , Korosteleva P. A.
Published: May 2021

Aim of the study: Using the example of a clinical case, to show the importance of dynamic observation by means of various diagnostic methods of intestinal imaging, in combination with a pathomorphological confirmation method for setting the correct clinical diagnosis. Materials and methods: The studies were performed on multislice computed tomographs Brilliance CT and ICT (Philips Medical Systems) and magnetic resonance imaging machines (GE), with intravenous contrast enhancement. We used special methods of contrasting the lumen of the intestine with gradual and retrograde filling it with water. The surgical material fixed in 10% neutral formuline for 10-24 hours. Tissue fragments were processed in a Leica TP1020 histoprocessor (Leica BioSystems, Germany) according to a standard protocol, after which it was embedded in paraffin blocks. Histological sections with a thickness of 3-5 μm were made by a Leica RM2245 microtome (Leica BioSystems, Germany). The prepared histological preparations were stained with hematoxylin and eosin in a Leica Autosteiner XL histostiner (Leica BioSystems, Germany). Results: From 2013 to 2020 patient K. underwent 4 colonoscopies, 5 esophagogastroduodenoscopies, 1 Х-ray examination with small bowel series, 3 MRI studies and 5 CT studies, including those with intravenous contrast enhancement, with a total radiation exposure of 187 mSv. The diagnosis was revised from ulcerative colitis, Crohn’s disease to NC. The final diagnosis was made by the pathologist’s analysis of materials. Conclusion: The clinical case presented by us clearly demonstrates the importance of dynamic observation by computed and magnetic resonance imaging, in combination with a pathomorphological confirmation method.
A case of massive recurrent small intestinal bleeding
Authors: Kortieva A. T. , Krushelnitskiy V. S. , Gabriel S. A. , Dynko V. Yu. , Guchetl A. Ya. , Babenko E. S.
Published: May 2021

The article presents a clinical case of massive recurrent bleeding from angioectasias of the jejunum in a 66-year-old patient. Within 13 months in the conditions of the GBUZ KKB No. 2, Krasnodar, the patient underwent: 1 video capsule examination of the small intestine, 3 esophagogastroduodenoscopy, 3 colonoscopy, 3 balloon-assisted enteroscopy. At the place of residence, the patient repeatedly underwent blood transfusions, as well as endoscopic examinations of the upper and lower parts of the digestive tract. In our facility, the patient underwent diagnostic laparoscopy, and twice-resection of the jejunum area that carries vascular malformation.
The need to strengthen measures for the diagnosis and treatment of Helicobacter pylori infection in Russia. Memorandum
Authors: Lazebnik L. B. , Bordin D. S. , Dekhnich N. N. , Kozlov R. S. , Livzan M. A. , Lyalukova E. A. , Luzina E. V. , Belova G. V. , Abdulkhakov R. A. , Abdulkhakov S. R.
Published: May 2021

Justification The participants of the round table on diagnosis and treatment of acid - and Helicobacter-dependent diseases, held on November 20, 2020 at the XXIII congress of the Scientific Society of Gastroenterologists of Russia within the framework of the XV National Congress of Therapists (Authors) having discussed the status of the issue, decided on the need to harmonize measures and pool efforts to reduce the incidence of H. pylori infection by approaching the medical community with this Memorandum.
Refocusing Neuroscience: Moving Away from Mental Categories and Toward Complex Behaviors
Authors: Pessoa Luiz , Medina Loreta , Desfilis Ester
Published: May 2021

Mental terms—such as perception, cognition, action, emotion, as well as attention, memory, decision making—are epistemically sterile. We support our thesis based on extensive comparative neuroanatomy knowledge of the organization of the vertebrate brain. Evolutionarypressures have molded the central nervous system to promote survival. Careful characterization of the vertebrate brain shows that its architecture supports an enormous amount of communication and integration of signals, especially in birds and mammals. The general architecture supports a degree of “computational flexibility” thatenables animals to cope successfully with complex and ever-changing environments. Here, we suggest that the vertebrate neuroarchitecture does not respect the boundaries of standard mental terms, and proposethat neuroscience should aim to unravel the dynamic coupling between large-scale brain circuits and complex, naturalistic behaviors.
Gauge and gravity, field membrane
Authors: Kuyukov Vitaly
Published: May 2021

Gauge and gravity, field membrane
Toward long-term laptop performances
Authors: Moustafa Khaled
Published: May 2021

To improve laptops’ performances over time and to keep them continuously upgradable, I suggest a new laptop design that includes external specific slots for CPU, RAM, Storage and Graphic card that should be connected to their internal counterparts to enhance their whenever needed. With each a new generation of these components, laptops can therefore be upgraded constantly to be up to date in terms of performance and versatility.
NLRC3 expression associates with survival in triple negative breast cancer.
Authors: Mamoor Shahan
Published: May 2021

We mined published microarray data (1) to understand the most significant gene expression differences in the tumors of triple negative breast cancer patients based on survival at time of analysis: dead or alive. The inflammasome component NLRC3 emerged as among the most significant differences, transcriptome-wide, when comparing the primary tumors of triple negative breast cancer patients dead or alive. Importantly, NLRC3 expression was significantly correlated with overall survival in basal subtype breast cancer, a molecular subtype sharing significant overlap with triple negative breast cancer. NLRC3 may be of relevance as a biomarker or as a molecule of interest in understanding the etiology or progression of triple negative breast cancer.
Holographic conformal memory and holographic flow
Authors: Kuyukov Vitaly
Published: May 2021

Holographic conformal memory and holographic flow
Effects of Demographic Factors on Impulse Buying Behaviour of Consumers in Auchi, Edo State, Nigeria
Authors: Ugbomhe O. Ugbomhe , P E. Okpamen , Adomokhai S. Simon
Published: May 2021

The objective of the study was to determine the effects of demographic factors (Age, Gender, Income, Education, Marital Status and Occupation) on impulse buying bahaviour of consumers in Auchi. The study adopted survey design. The population of the study consisted all consumers who have made purchases in their present shopping trip in selected shops (supermarkets). The sample size of 384 was determined using Godden’s formula cited in Sangatang, Siochi and Plaza (2017). The main research instrument was questionnaire which was used to survey 384 respondents (192 males and 192 females). Non-probability convenience sampling was used in administering copies of questionnaire to the respondents. Multiple regression analysis was used to determine result for the data collected with the aid of SPSS 20.0. The multiple regression analysis result revealed among others that demographic characteristics (age, gender, income, education, marital status) had significant relationship with impulse buying behavior of consumers. The study concluded that demographic characteristics of consumers could explain the impulse buying behavior of consumers. The reason is that the study showed significant relationship between demographic characteristics and impulse buying behaviour of consumers might be related to the respondent’s perception about purchasing decision. The study recommended that consumer should arrange their priorities and always weigh specific weight of their preferences in relation to each other according to a particular pattern when purchasing products to prevent buying on impulse.
RELATIONSHIP BETWEEN INCIDENCE AND SEVERITY OF PEANUT SMUT AND ITS REGIONAL DISTRIBUTION IN THE MAIN GROWING REGION OF ARGENTINA
Authors: Paredes Juan Andres , Edwards Molina Juan Pablo , Cazón Luis Ignacio , Asinari Florencia , Monguillot Joaquín Humberto , Morichetti Sergio Alejandro , Rago Alejandro Mario , Torres Adriana Mabel
Published: May 2021

Peanut smut, caused by the soil-borne pathogen Thecaphora frezii, has increased in incidence in the main Argentinian peanut-growing regions. Smut-affected pods transforms the kernel into a mass of teliospores, which survive long-term in the soil. This study is the first large-scale (regional) survey to determine the occurrence and distribution of peanut smut in the main growing area of Argentina. Surveys were conducted in Córdoba province, in randomly selected commercial peanut fields (n = 217) grown from 2015 to 2020. A five-score severity scale has been used to quantify the smut severity on pods (0 = healthy kernels and 4 = totally smutted kernels) and a disease severity index (DSI) is calculated. Pods with severity scores of 3 and 4 are rejected by the industry and produce a high volume of spores that spread among fields increasing the inoculum in the soil. Those pods were classified as severely damaged pods (SDP). We evaluated the relative frequency of smut classes during the years and established the relationships between the yearly incidence and DSI. The mean of the incidence was variable (never zero) across the years and increased from 1.66% in 2015 to 11.47% in 2020. More than 80% of the affected pods belonged to SDP group. The variable SDP, a more time and cost-effective method for quantifying peanut smut, best explained the variation in DSI values. Our results suggest that that visual estimates of incidence and SDP should be useful for disease monitoring, screening genotypes, or treatments comparisons in smut management experiments. Our data update knowledge of the distribution of T. frezii in the peanut-growing area of Argentina.
A Framework for Predicting Memory Errors with a Bayesian Model of Concept Generalization
Authors: Destefano Isabella , Brady Timothy F. , Vul Edward
Published: May 2021

“Similarity” is often thought to dictate memory errors. For example, in visual memory, memory judgements of lures are related to their psychophysical similarity to targets: an approximately exponential function in stimulus space (Schurgin et al. 2020). However, similarity is ill-defined for more complex stimuli, and memory errors seem to depend on all the remembered items, not just pairwise similarity. Such effects can be captured by a model that views similarity as a byproduct of Bayesian generalization (Tenenbaum & Griffiths, 2001). Here we ask whether the propensity of people to generalize from a set to an item predicts memory errors to that item. We use the “number game” generalization task to collect human judgements about set membership for symbolic numbers and show that memory errors for numbers are consistent with these generalization judgements rather than pairwise similarity. These results suggest that generalization propensity, rather than “similarity”, drives memory errors.
Psychophysical measures of tonotopic selectivity in cats and humans
Authors: Middlebrooks John C. , Guérit François , Richardson Matthew L. , Arneja Akshat , Harland Andrew , Gransier Robin , Carlyon Robert P.
Published: May 2021

Sound spectra are represented by patterns of activity along the tonotopic axis ofthe cochlea. Cochlear implants can transmit spectra by stimulating tonotopicallyappropriate electrodes, but fidelity is limited by intracochlear spread of excitation. We aim to better evaluate present-day experimental stimulation procedures and, potentially, to improve transmission of spectra with novel stimulation modalities. As a first step, we are developing non-invasive measures of tonotopic spread of excitation that can be compared between normal-hearing cats and humans. These measures include psychophysics in the present study and scalp-recorded electrophysiology in a companion study (Guérit et al., 2021). Cats and humans detected pure-tone probes presented in continuous 1/8- and 1-oct noise-band maskers. Masker bandwidths were readily discernable in both species by the dependence of masked thresholds on probe frequencies. Thresholds were largely constant across the bandwidth of the 1-oct masker, whereas thresholds dropped markedly at frequencies away from the center of the 1/8-oct masker. Cats and humans differed in that the feline auditory filter centered on 8 kHz, which we measured using a notched-noise procedure, was 22% wider than published values for humans at the same center frequency. Also, thresholds for the cats in the 1-octmasker condition consistently were 1.0 to 3.2 dB higher than expected based on the estimated masker power in the feline auditory filter. The present psychophysical results parallel those in our companion electrophysiological study, thereby providing perceptual validation for that study. These psychophysical and electrophysiological methods will be valuable for future investigations of novel approaches for auditory prosthesis.
Distributional learning of recursive structures
Authors: Li Daoxin , Schuler Kathryn
Published: May 2021

Languages differ regarding the depth, structure, and syntactic domains of recursive structures. Even within a single language, some structures allow infinite self-embedding while others are more restricted. For example, English allows infinite free embedding of the prenominal genitive -s, whereas the postnominal genitive of is largely restricted to only one level and to a limited set of items. Therefore, while the ability for recursion is considered as a crucial part of the language faculty, speakers need to learn from experience which specific structures allow free embedding and which do not. One effort to account for the mechanism that underlies this learning process, the distributional learning proposal, suggests that the recursion of a structure (e.g. X1’s-X2) is licensed if the X1 position and the X2 position are productively substitutable in the input. A series of corpus studies have confirmed the availability of such distributional cues in child directed speech. The present study further tests the distributional learning proposal with an artificial language learning experiment. We found that, as predicted, participants exposed to productive input were more likely to accept unattested strings at both one and two-embedding levels than participants exposed to unproductive input. Therefore, our results suggest that speakers can indeed use distributional information at one level to learn whether or not a structure is freely recursive.
English K-12 Teacher Experiences in Saudi Arabia in the Pandemic Era: A Follow-up Study of One Khbrat University Program
Authors: Daraghmeh Ahlam , Mead Hilary , Copeland Kathleen
Published: May 2021

A mixed-methods study examines the impact of the pandemic-driven move to virtual learning on K-12 (kindergarten through twelfth grade) English teacher experiences in Saudi Arabia to inform future development of the teaching of English in the country. Research is limited in K-12 English instruction in the country, and it is just emerging on the pandemic’s impact on education in the MENA region. The 35 subjects were English educators who completed the Saudi government-sponsored professional development program, Khbrat, at one U.S. university. Contextualized within the literature on technology in instruction, leadership frameworks, and Vision 2030 education reforms, the study explores the convergence of technological, institutional, and socio-cultural factors affecting innovation in English education to address the research question of how the pandemic has impacted Khbrat graduates as EFL teachers and as change agents in their country. Integrated analysis of survey and interview data reveals patterns of both acceleration and constraint. Findings suggest pathways to leverage virtual technology and acquired knowledge and skills of Khbrat English teacher graduates to deliver EFL professional development with a more pedagogical focus and to build coalitions among EFL educators to sustain the forward movement of innovation in English education in post-pandemic Saudi Arabia. The study concludes with recommendations for future applications.
PANDUAN LULUS CPNS & PPPK 2021DENGAN SKOR MAKSIMAL
Authors: Nurtiyasari Devi , Gunawan Agus Indra , Wulandari Nidya Ferry
Published: May 2021

Lulus CPNS membutuhkan perjuangan, kita tidak bisa mengandalkan keberuntungan semata. Selain banyak berdo‘a tentu teman-teman harus usaha yang maksimal. Usaha ini dapat dilakukan dengan banyak mengerjakan latihan soal, seperti soal-soal yang disusun dalam buku ini. Target buku ini membantu teman-teman lulus seleksi CPNS 2021 dengan skor/nilai maksimal baik Seleksi Kompetensi Dasar (SKD) maupun Seleksi Kompetensi Bidang (SKB). Agar lulus CPNS 2021, skor SKD tidak cukup dengan lulus passing grade saja, teman-teman harus mendapatkan skor maksimal agar masuk perangkingan 2x formasi. Selain mempersiapkan diri menghadapi SKD, agar lulus CPNS 2021 teman-teman juga harus mempersiapkan diri mengikuti seleksi tahap 2 yaitu SKB. Selain materi dan Latihan soal CPNS, buku ini juga dilengkapi materi seleksi PPPK. Buku ini disusun secara urut berdasarkan Peraturan Menteri Pendayagunaan Aparatur Negara dan Reformasi Birokarsi Republik Indonesia Nomor 23 Tahun 2019 (Permenpan RB No. 23 Tahun 2019) Tentang Kriteria Penetapan Kebutuhan Pegawai Negeri Sipil dan Pelaksanaan Seleksi Calon Pegawai Negeri Sipil Tahun 2019 dan Peraturan BKN No 1 Tahun 2019 tentang Teknis Pengadaan PPPK. Buku ini memberikan tips dan trik mengikuti tes seleksi CPNS dan PPPK 2021. Semoga buku ini dapat bermanfaat bagi teman-teman pejuang CPNS dan PPPK 2021.
On the calculus of Dirac delta function with some applications in classical electrodynamics
Authors: Kovacevic Milan S. , Jovanovic Miroslav R. , Milosevic Marko M.
Published: May 2021

The Dirac delta function is a concept that is useful throughout physics as a standard mathematical tool that appears repeatedly in the undergraduate physics curriculum including electrodynamics, optics, and quantum mechanics. Our analysis was guided by an analytical framework focusing on how students activate, construct, execute, and reflect on the Dirac delta function in the context of classical electrodynamics problems solving. It’s applications in solving the charge density associated with a point charge as well as electrostatic point dipole field, for more advanced situations to describe the charge density of hydrogen atom were presented.
Macro- and microenvironment, its impact on human health and longevity
Authors: Kazmirchuk V. E. , Orlik V. F.
Published: May 2021

Currently there is a revival of interest in the intestinal microflora and its influence on human health and illness. Well-tied food is the basis for vital activity not only the necessary microflora, and is a building material for the human immune system. Not an important meaning in human health has a macrobriety, the idea of ​​which is much more complicated. In the treatment of one of the family members, it is necessary to examine all members for the presence of this source of infection, without the elimination of which to achieve the effectiveness of treatment is not possible. Hormones, cytostatics, chemotherapy cannot eliminate the pathological process with a preserving pathogenetic factor. It should be striving to clarify the causes and factors that served as a breakdown of the immune response and the launch of the pathological process in the body. From the position of modern immunology, as well as the theories of micro and macrobractions, it is possible to achieve a healthy longevity.
Pathogenetic role of vitamin D deficiency and immune-inflammatory disorders in development of fetal distress in pregnant women with chronic hydramnion
Authors: Gaistruk N. A. , Dubas L. G. , Gaistruk A. N. , Melnik A. V. , Liovkina O. L.
Published: May 2021

The role of vitamin D deficiency and immune-inflammatory disorders in the mechanisms of development of fetal distress in pregnant women with chronic polyhydramnios remains unexplored. Objective: to evaluate the role of vitamin D deficiency and associated immune inflammatory disorders in the development of fetal distress in pregnant women with chronic polyhydramnios. Materials and methods. Surveyed 30 women with a physiological course of pregnancy and 90 pregnant women with chronic polyhydramnios. In the serum, the level of the metabolite of vitamin D – 25(OH)D and the cytokines IL-10 and IL-6 were determined by enzyme immunoassay using standard kits. Statistical processing of the obtained results was performed using standard methods using the «MS Excel» and «Statistica SPSS 10.0 for Windows» application package. The results of the research. In pregnant women with chronic polyhydramnios, there is a significant decrease of the metabolite of vitamin D – 25(OH)D level by 21 % in the serum, a decrease of the level of the anti-inflammatory cytokine IL-10 by 26.4 % and an increase of the concentration of pro-inflammatory IL-6 by 17 % compared to women with physiological course of pregnancy. The occurrence of fetal distress against the background of chronic polyhydramnios is accompanied by a intensification of vitamin D deficiency and immune-inflammatory disorders: levels 25(OH)D and IL-10, respectively, by 18.5 % and 17.5 % less, and IL-6 by 13.3 %, than in women with chronic polyhydramnios without fetal distress. The expressiveness of immune disorders in the organism of pregnant women with chronic polyhydramnios is determined by the level of vitamin D in the organism. Thus, in women with a deficiency of 25(OH)D in the serum, a significant decrease in the IL-10 concentration by 47.8 % and a significant increase in the IL-6 level by 34.6 % were recorded in comparison with the indicators in women with vitamin D deficiency. Conclusions. Vitamin D deficiency and associated immune-inflammatory disorders play an important role in the development of fetal distress in pregnant women with chronic polyhydramnios.
PECULIARITIES OF CLINICAL PASSING OF ATOPIC DERMATITIS AND VITAMIN D EXCHANGE IN EARLY CHILDREN
Authors: Kamut N. V. , Kiselova M. M.
Published: May 2021

The article is devoted to the study of features of clinical course of atopic dermatitis and vitamin D exchange in young children conducted by us by estimation of severity of atopic dermatitis depending on the value of SCORAD index, determination of 25(OH)D concentration in serum of children by immunochemical method with chemocentric analysis according to the classification approved by experts of the international endocrinological society. In the examination of 188 young children, two groups were formed on the basis of the Lviv City Children's Clinical Hospital. Children from 1 month to 1 year of age with manifestations of atopic dermatitis (n = 120), who were born full-term and had no birth defects, metabolic disorders, severe perinatal CNS lesions formed the main group. The comparison group consisted of 68 healthy young children without chronic diseases. All children had atopic dermatitis in the main group and were classified by severity (depending on the SCORAD index): children with mild severity – 31 (26 %), moderate 47 (39 %), and severe 42 (35 %). As a result of the study, we found a association between the severity of clinical manifestations of atopic dermatitis and the level of vitamin D in the serum. Comparative analysis of the severity of atopic dermatitis, depending on the level of vitamin D in the serum, showed that with severe atopic dermatitis in children of the main group, the level of 25(OH)D was significantly lower compared to its indicators in children with moderate to severe (P < 0.05). Serum vitamin D levels are significantly lower in all forms of atopic dermatitis severity and correlate significantly with the overall SCORAD severity score, erythema intensity, excoriation, itching, and sleep disturbances. The scientific data on the presence of feedback correlation (r = –0,48; P < 0,05) between the development of atopic dermatitis in children and their level of 25(OH)D in serum were added. Our findings suggest that there is a need for a differentiated approach to treating early-stage atopic dermatitis of varying severity, a personalized therapeutic approach to choosing a vitamin D supplementation, given the level of 25(OH)D in the serum.