bluuebunny/crossref_metadata_2025 huggingface dataset:
EVOLUTION OF THE INCIDENCE OF NOTIFIABLE SEXUALLY TRANSMITTED INFECTIONS IN ARAGON.
Authors: Rubén Aced Magaña , Isabel Cólera Gómez , Ana María Morón Esteban , Ana Saide Gabro Marcén , Micaela Ardid Pardo , Teresa Peón Sánchez
Published: August 2024

Se entiende como infección de transmisión sexual (ITS) aquella que se transmite principalmente por contacto sexual, aunque en ocasiones puede ocurrir por otras vías como la sanguínea o de madre a hijo/a durante el embarazo. Si no son tratadas adecuadamente, estas infecciones pueden tener consecuencias graves para la salud e incluso ser potencialmente mortales. En el contexto español, la situación actual en cuanto a la incidencia de ITS es alarmante, habiéndo alcanzado niveles históricos según los registros disponibles. Se plantea la necesidad de investigar si la situación en la comunidad autónoma de Aragón refleja un patrón similar, con el propósito de obtener una visión clara y actualizada de la situación y así implementar medidas efectivas para abordar este problema de salud pública.
REKURRENT RESPİRATOR İNFEKSİYALARIN KONSTİTUSİONAL-BİOLOJİ AMİLLƏR ƏSASINDA PROQNOZLAŞDIRILMASI
Authors: Барчан Г.С. , Черкашина Л.В. , Шкляр А.С. , Омарова О.Н. , Гайдаш Е.И. , Демихов А.И. , Куц Л.В. , Демихова Н.В.
Published: August 2024

Проведено систематизированное исследование по влиянию конституционально-биологических маркеров (КБМ) и стигм дисэмбриогенеза, их диагностического и прогностического значения в отношении формирования рекуррентных респираторных инфекций в детском возрасте. Выполнено ранговое распределение по показателю диагностической ценности достоверных и одновременно высоко информативных КБМ, а также детальный клинико-статистический анализ 10 наиболее информативных КБМ. В исследовании двух групп детей (с рекуррентными респираторными инфекциями и без них) определены диагностическая ценность и прогностическое значение КБМ и выявлены достоверные различия между группами по 32 из 43 маркеров недифференцированной дисплазии соединительной ткани. Доказано, что наиболее диагностически ценными и прогностически значимыми конституционально-биологическими факторами являются показатели гармоничности структуры массы тела и отдельные стигмы дисэмбриогенеза.

Uşaq yaşlarında rekurrent respirator infeksiyaların (RRİ) yaranmasının və inkşafının proqnozlaşdırılmasında konstitusional-bioloji markerlərdən (KBM) və disembriogenez əlamətlərindən istifadə edilməsinin mümkünlüyünün aydınlaşdırılması məqsədilə tədqiqat aparılmışdır. KBM-in etibarlılığına və diaqnostik dəyərliliyinə əsaslanan dərəcələr üzrə sırası tərtib edilmiş və onların informativliyi yüksək olan 10 növünün klinik-statistik təhlili aparılmışdır. İki qrup (RRİ olan və olmayan) uşaqda KBM-in diaqnostik dəyəri və proqnostik əhəmiyyəti aydınlaşdırılmış, həmçinin diferensiasiya etməmiş birləşdirici toxuma displaziyasının 43 markerindən 32-sinin qruplar arasında etibarlı fərqləri müəyyənləşdirilmişdir. Sübut edilmişdir ki, RRİ-nin diaqnostikası və proqnozlaşdırılması üçün ən əhəmiyyətli konstitusional-bioloji amillərə bədən kütləsi strukturunun harmonikliyi və disembriogenezin bəzi markerləri aiddir.

A systematic study was conducted on the effect of constitutional biological markers (CBM) and the stigma of dysembryogenesis, their diagnostic and prognostic value in relation to the formation of recurrent respiratory infections in childhood. The ranking distribution according to the diagnostic value indicator of reliable and at the same time highly informative CBM, as well as a detailed clinical and statistical analysis of the 10 most informative CBM, were made. A study of two groups of children (with and without recurrent respiratory infections) determined the diagnostic value and prognostic value of constitutional and biological factors and revealed significant differences between groups of 32 out of 43 markers of undifferentiated connective tissue dysplasia. It is proved that the most diagnostically valuable and prognostically significant constitutional and biological factors are indicators of the harmony of the body mass structure and individual stigmas of dysembryogenesis.
XRONİK GENERALİZASİYA ETMİŞ PARODONTİTİN ETİOPATOGENEZİNİN MÜASİR ASPEKTLƏRİ
Authors: Щерба В.В. , Антонишин И.В. , Криницкая И.Я. , Марущак М.И. , Камышный А.М. , Корда М.М.
Published: August 2024

В статье представлен обзор литературы по изучению этиопатогенеза хронического генерализированного пародонтита. Несмотря на большое количество научных работ по данному вопросу, сегодня недостаточно установлена роль некоторых разновидностей микроорганизмов в развитии генерализованного процесса воспаления и деструкции в пародонте. Недостаточно изученными являются взаимодействия между перекисным окислением липидов и протеинов, а также антиоксидантной системой при пародонтите. Практически отсутствуют данные о вкладе изменения функциональной, метаболической активности и особенностей реализации программируемой гибели клеток-эффекторов воспаления, в частности нейтрофилов крови в патогенезе пародонтита. Противоречива информация о том, как влияет дисфункция системы нитроген (II) оксида и гидроген-сульфида на течение пародонтита. Поэтому дальнейшие исследования, направленные на изучение этиопатогенеза хронического генерализованного пародонтита, являются актуальными и перспективними.

Məqalədə xronik generalizasiya etmiş parodonitin etiopatogenezinə dair ədəbiyyat icmalı təqdim edilir. Bu problemə çoxsaylı elmi tədqiqat işləri həsr edilmiş olsa da, parodontun generalizasiya etmiş iltihabının və destruksiyasının inkişafında bəzi mikroorqanizm növlərinin rolu tam aydınlaşdırılmayıb. Parodontitin patogenezində lipidlərin və proteinlərin peroksidləşmə yolu ilə oksidləşməsinin, həmçinin antioksidant sisteminin rolu da hələləik tam aydınlaşdırılmayıb. Adı çəkilən xəstəliyin patogenezində iltihab effektorları olan hüceyrələrin funksional və metabolik xüsusiyyətlərinin rolu və proqramlaşdırılmış ölümün xüsusiyyətləri haqqında da kifayət qədər məlumat yoxdur. Azot (II) oksid və hydrogen-sulfid sisteminin disfunksiyasının parodontitin gedişinə təsiri haqqında olan ədəbiyyat məlumatları da ziddiyyətlidir. Buna görə müəlliflər bu fikirdədirlər ki, xronik generalizasiya etmiş parodontitin etiopatogenezinin tədqiqi hələlik öz aktuallığını itirməmişdir.

The article presents a review of the literature data on the investigation of chronic generalized periodontitis etiopathogenesis. Despite the large number of research papers on this issue, today the role of some varieties of microorganisms in the development of a generalized process of inflammation and destruction in periodontium is not sufficiently established. The interactions between lipid and protein peroxidation and the antioxidant system in case of periodontitis are not well understood. There is practically no data on the contribution of changes in functional, metabolic activity and features of the implementation of programmed death of inflammatory effector cells, in particular blood neutrophils in the pathogenesis of periodontitis. Information on how the dysfunction of the nitrogen (II) oxide system and hydrogen sulfide affect periodontal disease is contradictory. Therefore, further studies aimed to investigate the etiopathogenesis of chronic generalized periodontitis are relevant and promising.
PREEKLAMPSİYAYA QARŞI PROFİLAKTİK TƏDBİRLƏRİN FETOPLASENTAR KOMPLEKSİN VƏZİYYƏTİNƏ TƏSİRİ
Authors: Həmidova A.V. , Bağırova H.F.
Published: August 2024

Məqalədə preeklampsiya əleyhinə profilaktik tədbirlərin fetoplasentar kompleksin vəziyyətinə təsirini öyrənmək məqsədilə aparılan tədqiqat haqqında məlumat verilmişdir. Tədqiqata hestasiyanın ikinci (22-27 h.h.) və üçüncü (28 h.h.≤) trimestrlərində olan 145 hamilə qadın cəlb olunub. 1-ci qrupa (müqayisə qrupu) – hamiləlikləri preeklampsiya ilə ağırlaşan 80 hamilə qadın (profilaktik tədbirlər aparılmayan), 2-ci qrupa (əsas qrup) – preeklampsiyanın inkişafına görə risk qrupuna daxil olan 65 hamilə qadın (hestasiyanın 13-cü həftəsindən profilaktik tədbirlər aparılan) daxil edilib. Müayinə qruplarında hamilələrə “GE.Voluson E8 expert” cihazında ultrasəs və dopplerometriya müayinələri aparılmışdır. Alınmış verilənlər arasındakı fərqin statistik əhəmiyyətliliyi Fişerin dəqiq testi (Fisher’s exact test) vasitəsilə müəyyən edilmişdir. Tədqiqat göstərmişdir ki, əsas qrupda aparılan profilaktik tədbirlərin fonunda bir sıra ultrasəs (ciftin hipertrofiyası, xovarası sahələrin kistoz genişlənmələri, ciftin vaxtından qabaq yetişməsi, dölyanı mayenin həcminin azalması, dölün bətndaxili inkişaf ləngiməsi) və dopplerometriya (uşaqlıq-cift-döl qan dövranının pozulması) göstəriciləri müqayisə qrupuna nisbətən statistik etibarlı azalmışdır. Beləliklə, hamiləliyin erkən müddətlərindən (cift formalaşana kimi) profilaktik tədbirlərin aparılması fetoplasentar kompleksin vəziyyətinə müsbət təsir edərək, nəticədə hestasion və perinatal nəticələri yaxşılaşdırmağa imkan verib.
СИМУЛЬТАНТНОЕ ОПЕРАТИВНОЕ ЛЕЧЕНИИ ГЕМОРРОЯ И АНАЛЬНОЙ ТРЕЩИНЫ
Authors: Ноес А.Д. , Фелештинський Я.П. , Пироговский В.Ю. , Сорокин Б.В. , Йосипенко М.А.
Published: August 2024

В статье изложены результаты исследования, проведенного с целью обоснования выполнения симультантного оперативного лечения геморроя и анальной трещины с использованием трансанальной геморроидальной деартериализации. В исследование приняли участие 177 пациентов. I группа 60 пациентов, которым проведена геморроидэктомия по Милиган-Морган и удаление анальной трещины, II – 60 пациентов, которым только удалена анальная трещина, III – 57 пациентов, прооперированных оригинальным способом. Пациентам ІІ и ІІІ групп проводилась лазерная Допплерная флоуметрия с целью оценки интенсивности кровотока в зоне операции. Исследование показало, что симультантное иссечение трещины и трансанальная геморроидальная деартериализация позволяет улучшить результаты лечения пациентов с сочетанием геморроя и анальной трещины путем одновременного уменьшения кровоснабжение 96 кавернозной ткани геморроидальных узлов и улучшения кровотока в зоне предыдущего существования трещины за счет ликвидации дефекта слизистой оболочки анального канала и сфинктероспазма при минимальной травматизации анального канала.
POSTOPERASİON YIRTIQLARIN MEYDANA ÇIXMASINDA QARIN DİVARININ TİKİLMƏSİ ZAMANI TƏTBİQ EDİLƏN TEXNİKİ ÜSULLARIN ROLU
Authors: Zeynalov N.C. , Rüstəmov E.A. , Həsənov A.R.
Published: August 2024

Məqalədə postoperasion yırtıqların meydana çıxmasında qarın divarı tikilərkən tətbiq edilən cərrahi üsulların rolunun öyrənilməsi məqsədilə aparılmış tədqiqat işi barədə məlumat verilmişdir. Tədqiqata açıq üsulla böyük abdominal əməliyyatlara məruz qalmış və postopersion yırtıqların meydana çıxması baxımından uzaq nəticələri öyrənilmiş 137 xəstənin materialları daxil edilmişdir. 10 xəstədə (7,3%) postoperasion yırtıqlar meydana çıxmışdır. Reverdin-Multanovski üsulu ilə fasiləsiz ”kilidli” tikiş texnikası tətbiq edilmiş 26 xəstədən 4-də (15,38%), cərrahi kəsiyi böyükölçülü adi fasiləsiz üsulla tikilmiş 62 xəstədən 6-da (9,68%) yırtıqlar müəyyən edilmiş, kiçikölçülü tikiş texnikası tətbiq edilmiş 49 xəstədən isə heç birində yırtıq qeydə alınmamışdır. İstifadə edilmiş sapın uzunluğunun yara uzunluğuna nisbəti (SU:YU) yırtıq törənmiş xəstələrdə orta hesabla 2,5±0,2, yırtıq yaranmamış xəstələrdə 3,0±0,06 olmuşdur. Ən yüksək rastgəlmə tezliyi (16,13% ) isə SU:YU nisbəti 3-dən kiçik olmaqla böyük tikiş texnikası tətbiq edilmiş xəstələrdə müşahidə edilmişdir. Aparılan çoxvariantlı analizlər qeyri-cərrahi risk amilləri ilə yanaşı, ”kilidli” fasiləsiz və SU:YU < 3 olmaqla böyükölçülü adi fasiləsiz tikiş texnikalarının tətbiqinin müstəqil risk faktoru təşkil etdiyini və kiçiktikişli texnikanın daha effektiv üsul olduğunu göstərmişdir
YENİ TƏDRİS TEXNOLOGİYALARI ÜZRƏ TƏHSİLALANLARIN FİZİKİ FƏALLIQ SƏVİYYƏSİNİN ÜRƏK-DAMAR SİSTEMİNİN FUNKSİONAL İMKANLARINA TƏSİRİ
Authors: Balayeva Ş.M.
Published: August 2024

Məqalədə tədris zamanı müxtəlif səviyyəli hərəki fəallıq mühitinin “Sağlam Təhsil” və ənənəvi təhsil siniflərində təhsil alan 6-9 yaşlı ibtidai sinif şagirdlərinin ürək-damar sisteminin funksional göstəricilərinə təsirini öyrənmək məqsədilə aparılan tədqiqat işi haqqında məlumat verilmişdir. Ürək-damar sisteminin funksional vəziyyətini qiymətləndirmək məqsədilə PWC170 funksional sınağı və adaptasiya potensialı göstəricisindən istifadə edilmişdir. Tədqiqat göstərmişdir ki, “Sağlam Təhsil” siniflərində yaradılan şərait təhsilalanların hərəki fəaliyyət həcminin 2-2,5 dəfə artmasına imkan verir. Məktəblilərin hərəki fəaliyyətinin artması orqanizmin funksional ehtiyatlarının yaxşılaşmasına şərait yaradır, ürək-damar sisteminin adaptasiya qabiliyyətini yaxşılaşdırır. 3-cü tədris ilinin sonunda “Sağlam Təhsil” siniflərində kafi adaptasiyalı uşaqların sayı dürüst olaraq ənənəvi təhsil siniflərindən yüksək (“Sağlam Təhsil” sinifləri – 73,4%, ənənəvi təhsil sinifləri – 57,6%; p<0,01), adaptasiya potensialının gərginliyi olan uşaqların sayı isə az olmuşdur (müvafiq olaraq 19,8% və 36,3%; p<0,01). “Sağlam Təhsil” siniflərində təhsil alan oğlanlarda üçüncü tədris ilinin sonunda PWC170 göstəricisi orta kəmiyyətinin nisbi artımı 20,0% (р˂0,005), qızlarda isə16,3% (p˂0,01) təşkil etmişdir, bu isə ənənəvi təhsil siniflərinə nisbətən 3 dəfədən yüksəkdir (müvafiq olaraq 6,0 və 5,7%). Təhsilalanların iş qabiliyyətinin saxlanılması və təhsil yorğunluğunun profilaktikası məqsədilə təlim-tərbiyə prosesində hərəki fəaliyyətin artırılması üçün tədbirlər görülməlidir
XRONİK SİSTİTİN FOTODİNAMİK MÜALİCƏSİ
Authors: Баранов А.В. , Корнев А.И. , Борискин А.А. , Мустафаев Р.Д. , Дербенев В.А. , Лазечко М.И. , Мусинова Я.Р.
Published: August 2024

Представлены результаты исследования, проведенного с целью сравнения эффективности лечения больных хроническим циститом стандартными методами и дополнения последних фотодинамической терапией. Проведен анализ результатов лечения 45 больных хроническим циститом. Основную группу составили 25 человек, контрольную – 20. Больным основной группы, в отличие от контрольной, традиционное лечение дополняли интрапузырной фотодинамической терапией. Исследование показало, что у больных основной группы отмечено более быстрое разрешение воспалительного процесса по сравнению с контрольной группой и отсутствие рецидива заболевания. Таким образом, дополнение традиционного лечения лазерными технологиями улучшает результаты лечения больных хроническим циститом.

Məqalədə xronik sistitli xəstələrin standart metodlarla və əlavə olaraq fotodinamik terapiya üsulu ilə müalicəsinin effektivliyini müqayisə etmək məqsədilə aparılmış tədqiqat işi haqqında məlumat verilmişdir. Xronik sistiti olan 45 xəstənin müalicəsinə dair klinik materiallar təhlil edilmişdir. Əsas qrupa 25, kontrol qrupuna isə 20 xəstə daxil edilib. Əsas qrupun xəstələrinə kontrol qrupdan fərqli olaraq ənənəvi müalicə kursundan əlavə kisədaxili fotodinamik üsulla müalicə aparılmışdır. Tədqiqat göstərmişdir ki, əsas qrupun xəstələrində iltihabi proses daha sürətlə sağalır və xəstəlik bir daha residiv vermir. Beləliklə, xronik sistitli xəstələrin ənənəvi müalicə prosesinə lazer texnologiyası üsulunun əlavə edilməsi müalicənin nəticələrini yaxşılaşdırır.

A study was conducted to compare the effectiveness of photodynamic therapy and standard methods for treating chronic cystitis. The study analyzed the treatment outcomes of 40 patients, with 25 in the main group and 20 in the control group. The main group underwent photodynamic therapy while the control group received standard treatment. Results showed that patients in the main group experienced faster resolution of the inflammatory process compared to the control group. These findings suggest that laser technologies can improve the treatment outcomes for patients with chronic cystitis.
ЧАСТОТА ВСТРЕЧАЕМОСТИ ФОРМ ОНИХОМИКОЗА И НОЗОЛОГИЙ СОПУТСТВУЮЩИХ ЗАБОЛЕВАНИЙ КОЖИ У ВОЕННОСЛУЖАЩИХ
Authors: Güliyeva R.A.
Published: August 2024

Ayaq epidermofiti və rubromikozu qeydə alınan dəri mikozu olan pasiyentlərdə onixomikozun formaları, yanaşı dəri patologiyalarının rast gəlinməsi və nozoloji strukturu, göbələk infeksiyasından qaynaqlanan ağırlaşmalar və onların strukturunun müəyyənləşdirilməsi məqsədilə daxili qoşunların ayaq epidermofiti olan 125 nəfər və ayaq rubromikozu olan 125 nəfər (ümumilikdə 250 nəfər) dəri mikozlu olan hərbi qulluqçusu tədqiqata cəlb edilmişdir. Onixomikozun normotrofik və hipertrofik formalarının paylanması müəyyənləşdirildikdə ayaq dermofiti olan dəri mikozlu pasiyentlərdən 76,8±3,78%-də onixomikozun normotrofik forması qeydə alınmışdır. Ümumilikdə ayaq rubromikozu və ayaq epidermofiti olan, dəri mikozundan əziyyət çəkən pasiyentlərdən 16 nəfərdə göbələk infeksiyası mənşəli ikincili piodermit qeydə alınmışdır. İkincili infeksiyası olan pasiyentlərdən 25,0±10,8%-də allergik dermatit müşahidə edilmişdir.

С целью определения форм онихомикоза у больных микозами кожи с эпидермофитами стоп и рубромикозами, частоты встречаемости и нозологической структуре сопутствующей кожной патологии, осложнений, вызванных грибковой инфекцией и их структуры обследовано 125 человек с эпидермофитами стоп и 125 человек с рубромикозами стоп. Всего в исследовании приняли участие 250 военнослужащих внутренних войск с микозами кожи. На этапе, когда определяли распределение нормотрофической и гипертрофической форм онихомикоза, нормотрофическая форма онихомикоза регистрировалась у 76,8±3,78% больных микозом кожи с дермофитиями ног. Всего вторичная пиодермия грибковой инфекции зарегистрирована у 16 больных микозом кожи с рубромикозом стопы и эпидермофитией стопы. Аллергический дерматит наблюдался у 25,0±10,8% больных с вторичной инфекцией.

In order to determine the forms of onychomycosis in patients with skin mycosis accompanied by foot epidermophytosis and rubromycosis, the occurrence and nosological structure of concomitant skin pathologies, and the complications caused by fungal infections and their structure, a total of 250 military personnel from internal troops with skin mycosis were involved in the study. This included 125 people with foot epidermophytosis and 125 people with foot rubromycosis. During the phase where we determined the distribution of normotrophic and hypertrophic forms of onychomycosis, the normotrophic form was recorded in 76.8±3.78% of patients with skin mycosis and leg dermophytosis. In total, secondary pyoderma from fungal infection was recorded in 16 patients suffering from skin mycosis with foot rubromycosis and foot epidermophytosis. Allergic dermatitis was observed in 25.0±10.8% of patients with secondary infection.
DEMOGRAPHIC AND PROFESSIONAL RISKS OF DEPOPULATION AMONG WORKING POPULATION IN RUSSIA: 14 YEARS LATER (analytical review)
Authors: Башкирёва А.С. , Шишко А.В. , Богданова Д.Ю. , Аникеев П.П.
Published: August 2024

В статье представлен сравнительный анализ процесса старения населения в контексте демографических и профессиональных рисков депопуляции работающего населения в России. Приведены основные медико-демографические показатели старения населения для России и развитых стран. Проанализированы результаты прогнозов ООН, вероятностных прогнозов общей численности и ряда характеристик структуры по возрасту и полу для населения РФ. Убедительно показано состояние демографического неблагополучия в России и мире. Особое внимание уделено рассмотрению демографических рисков сокращения численности населения в рабочих возрастах, увеличению нагрузки на трудоспособное население. Доказана необходимость дальнейших исследований, посвященных использованию геропротекторов и современных геронтотехнологий в качестве средств и методов профилактики преждевременного снижения профессиональной работоспособности, замедления процессов старения организма работающих, снижения уровня смертности трудоспособного населения и увеличения профессионального долголетия.

The article presents a comparative analysis of the process of population aging in the context of demographic and professional risks of depopulation among working population in Russia. The values of the main medical and demographic indicators of population aging for Russia and developed countries were given. The results of UN forecasts, probabilistic forecasts of the total number and some characteristics of the age-sex structure for the population of the Russian Federation were analyzed. The state of demographic disadvantage in Russia and in the world was convincingly shown. Particular attention was paid to the consideration of the demographic risks of a reduction in the working-age population and an increase in the burden on the working-age population. The need for further research on the use of geroprotectors and modern gerontotechnologies as means and methods for preventing premature decline in work ability, slowing down the aging process of workers, reducing the mortality rate among working population and increasing professional longevity has been proven.
THE RELEVANCE OF DIASTOLIC RESERVE OF THE LEFT VENTRICLE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS (literature review)
Authors: Товмасян К.Р. , Оракова Ф.Х.
Published: August 2024

Сахарный диабет 2-го типа (СД2) является одним из самых распространенных неинфекционных заболеваний в мире. Среди лиц с СД2 преобладают пациенты старшей возрастной группы. Углубленное понимание ранних сердечно-сосудистых проявлений диабета занимает важное место в международных исследованиях и программах профилактики, учитывая, что сердечно-сосудистые осложнения являются основной причиной смерти пациентов с диабетом. Последние исследования оценки диастолической дисфункции ЛЖ методом эхо-КГ как характерного предиктора развития кардиомиопатии показали, что обновленный алгоритм более информативен для определения диастолической дисфункции ЛЖ у пациентов при прогнозировании сердечно-сосудистых осложнений.

Type 2 diabetes mellitus is one of the most common non-infectious diseases in the world. Among people with type 2 diabetes, patients of the older age group. An in understanding of the early cardiovascular manifestations of diabetes occupies an important place in international research and prevention programs, given that cardiac vascular complications are the cause of death in patients with diabetes. Recent studies evaluating left ventricular diastolic dysfunction as a characteristic predictor of diabetic cardiomyopathy by echocardiography. In accordance with the recommendations for diastolic dysfunction, have shown that the algorithm of the informative algorithm is used to determine left ventricular diastolic dysfunction in patients with prognosis in predicting cardiovascular complications.
MECHANISMS OF AGING AND AGE-RELATED HOMEODYNAMICS OF BIO-ELEMENTOME
Authors: Луговая Е.А. , Агеенко К.И.
Published: August 2024

Данная статья представляет собой обзор литературы и собственные рассуждения на тему биоэлементно опосредованного старения организма человека. Исследование биоэлементологических основ старения в настоящее время одно из активно развивающихся направлений геронтологической науки. Состояние биоэлементома на протяжении постнатального онтогенеза не является стабильным. Уровни макро- и микроэлементов, являясь чрезвычайно зависимыми от обстоятельств эндо- и экзогенного характера, могут как сохраняться в рамках нормы, так и претерпевать существенные изменения, особенно в процессе возрастных изменений организма. Биоэлементомные перестройки весьма значимы для большого количества известных на сегодняшний день молекулярных, субклеточных, клеточных и тканевых механизмов старения (окислительного стресса, дефектного протеостаза, избыточного укорочения теломер, изменения эпигенетического ландшафта, апоптоза, нарушения межклеточной коммуникации и многих других). Понимание метаболических путей эссенциальных биоэлементов (поступление в ЖКТ, абсорбция, в том числе благодаря взаимодействию с особыми белками-транспортерами, транспорт по кровеносной системе, распределение в организме, включение в специализированные макромолекулы, участие в их составе в биохимических процессах, выведение из организма), их роли в механизмах возрастной инволюции тканей и органов и особенностей возрастной гомеодинамики могут существенно расширить имеющиеся представления о биологии старения.

This article presents a data science review and our own evaluation on bio-element mediated aging of the human body from the point of view of homeodynamics of bioelementome. The study of bio-element basis of aging is currently one of the actively developing fields in gerontology. During postnatal ontogenesis, the bio-elementome shows no signs of stability. Being extremely dependent on endogenous and exogenous circumstances, the levels of macro- and microelements can either remain within the normal range or undergo significant changes, especially with the body aging. These bio-element developments appear to be very important in terms of a large number of currently known molecular, subcellular, cellular, and tissue mechanisms of aging (oxidative stress, loss of proteostasis, excessive telomere attrition, epigenetic landscape alterations, apoptosis, altered intercellular communication, and many others). Better understanding of metabolic pathways of essential bio-elements (intake in the gastrointestinal tract; absorption, including due to interaction with specific transporting proteins; spread through the circulatory system and the entire body; inclusion in specialized macromolecules and participation in their composition in biochemical processes; excretion from the body), as well as realizing their role in the mechanisms of senile tissue and organ involution, and features of age-related homeodynamics can significantly improve existing knowledge on the biology of aging.
An analysis of the implications of taxation on equity in relation to national development
Authors: Maulana Ayang Fristia , Apiati Siti Nurfadilah , Arofah Laila , Aditiya Arya , Solihin Muhammad
Published: August 2024

Taxation is a very important instrument for a government in collecting funds to finance various development programs, the nature of this tax is mandatory. Apart from that, this tax system can be designed as well as possible, by making it a tool to achieve social and economic justice, through income redistribution. National development is taxation carried out effectively with the aim of reducing economic imbalances between regions and increasing investment in social services. Excessive or unfair taxation can discourage investment and can destroy incentives to work. This increase in taxes on development can be done to increase the number of buildings owned by Indonesia. With tax reform that focuses on justice and efficiency, this can support a more sustainable national development.
Legal protection for Indonesian workers in various countries Adenpati
Authors: Turnip Agripa , Surbakti Adenpati , Br Pandia Jemita , Harahap Rasyd , Wardana Sitti , Tanjung Indra U
Published: August 2024

The placement of migrant workers abroad is carried out by upholding human dignity, human rights, legal protection, equal employment opportunities and providing employment opportunities and employee training in accordance with national needs. However, violence often befalls Indonesian workers in their destination countries. So Indonesia created legislation in the form of protection for Indonesian workers, an international convention on protecting the rights of all migrant workers and their families which is often referred to as ICRMW. The ICRMW Agreement describes human rights contained in international law on economic, social and cultural rights and international law on civil and political rights specifically states how these different rights apply to different categories of migrant workers. Legal protection for the rights and obligations of migrant workers abroad is stated in a mutually agreed work relationship. Article 2 of Law Number 39 of 2004 regulates the principles of integration, harmony of rights, democracy, equality in society, justice, gender equality and anti-human trafficking. This is a form of legal protection for Indonesian workers
The risk of physical environment on the incidence of pneumonia in the Puskesmas Remu Sorong City
Authors: Pangaribuan Sariana , Siagian Jenni Lilis , Sanoy Yustinus Derek , Talakua Febri , Artafella Agung
Published: August 2024

Pneumonia is a respiratory infection that attacks the lungs, the World Health Organisation (WHO) recorded 2.5 million people died from pneumonia. Based on preliminary data collection, in January-June 2022 there were 17 cases and 34 controls, in the Remu Health Centre working area of Sorong City. The purpose of this study was to determine the risk of house building, house lighting, house humidity, house ventilation, and occupancy density on the incidence of pneumonia among under-fives in the Remu Health Centre working area  of Sorong City. This type of research is analytic observation, with a case control design, using the odds ratio (OR) test to determine the magnitude of risk. This study was conducted in the Remu Health Centre working area of Sorong City on 22 September 22 October with a total sample of 51 children under five years old. The results showed that there was a risk, house building (OR=7.538), house lighting (OR=2.417), house humidity (OR=2.531), house ventilation (OR=3.714), occupancy density (OR=3.210), to the incidence of pneumonia. Conclusion House building, house lighting, house humidity, house ventilation area, and occupancy density are risk factors for the incidence of pneumonia among under-fives in the Remu Puskesmas working area of Sorong City.
The Effect Of Boiled Sail Leaf Water On Blood Pressure In Hypertension Patients
Authors: Rini Rini , Sylvia Ester Inung , Kusnaningsih Aida , Datak Gad
Published: August 2024

Hypertension is a major health problem that can cause complications from various diseases such as heart disease, stroke, kidney failure and other diseases. One effort to lower blood pressure is with bay leaf boiled water therapy. Bay leaves contain flavonoids which function to relax arterial muscles so they can reduce high blood pressure in hypertensive patients. The aim of the research was to determine the effect of bay leaf boiled water therapy on blood pressure in hypertensive patients. The research design used a quasi-experiment with a one group pre-post test design approach, the sample size was 39 people using a purposive sampling technique. The patient drank water boiled with bay leaves ½ glass in the morning and ½ glass before eating for 2 weeks. Blood pressure was measured before and after drinking boiled bay leaves. The results of the research before therapy were carried out, the average systolic blood pressure was 160.67 mmHg and diastolic 93.1 mmHg, after therapy with bay leaf boiled water the average systolic blood pressure was 147.74 mmHg and diastolic 81.72 mmHg. The results of the analysis showed that bay leaf boiled water therapy had an effect on reducing blood pressure in hypertensive patients at the Menteng Community Health Centers, Palangka Ra (p=0.00)
Factors related to adolescent women's readiness for menarche
Authors: Pratiwi Debby , Br. Sembiring Eliya Rosa , Marlina Marlina
Published: August 2024

Menarche is the first natural bleeding occurring in teenage women where blood comes out of the vagina or can be called the first menstruation. Menarche is an early sign of other changes such as breast growth, hair growth in the pubic and axillary areas, and fat distribution in the hip area. Objective: This research determines the factors related to the readiness of young women to face menarche in young women at Baitul Aziz High School, Percut Sei Tuan District, Deli Serdang Regency in 2023. This type of research is an Analytical Survey of researchers who try to explore how and why this phenomenon occurs and this research uses a cross-sectional approach, namely finding out what factors are related to the readiness of young women to face menarche. The sample used was 40 people. Data analysis in this study was univariate and bivariate analysis using the Chi-square test with a=0.05. Based on the results of the Chi-square statistical test, this research found that there was a relationship between the readiness of young women to face menarche, namely the knowledge factor with a p-value = 0.001, the attitude factor with a p-value = 0.000, and the family support factor with a p-value -value= 0.003 so all Ho are rejected (p<0.05). Baitul Aziz High School, Percut Sei Tuan subdistrict, Deli Serdang district, to foster more motivation, enthusiasm and increase knowledge when facing menstruation for the first time (menarche).
Combination of Slow Deep Breathing Technique and Lavender Aromatherapy on Labor Pain Intensity Period I Active Phase in Maternity Patients Primipara at dr. Abdul Rivai Berau Hospital
Authors: Sari Vezi Desma , Purwanti Heni , Meihartati Tuti , Hartati Dwi
Published: August 2024

Labor pain in the first stage of the active phase felt by primiparous mothers at dr. Abdul Rivai Hospital is like a strong and very scary stab, and in facing labor pain, primiparous mothers do not know how to deal with the pain they feel, so some primiparous mothers are agitated, screaming, hitting their husbands, asking for a Caesarean section without medical indication. This study aimed to determine the effect of the combination of the Slow Deep Breathing technique and lavender aromatherapy on the intensity of labor pain during the first active phase in primiparous mothers giving birth. The Study used pre-experimental methods and a group Pre-Test-Post-Test Design with a population of primiparous mothers giving birth at Dr Abdul Rivai Hospital, Berau Regency, with an average of 43 people per month, based on the Lameshow formula with a sample of 35 people. The research instrument uses the NRS scale. Data analysis used the Wilcoxon test. The score for labor pain in the first stage of the active phase before the combination of the Slow Deep Breathing technique and lavender aromatherapy carried was 8, and after the combination of the Slow Deep Breathing technique and lavender aromatherapy was 7. There is an effect of the combination of the Slow Deep Breathing technique and lavender aromatherapy on the intensity of labor pain in the active phase of the first stage in primiparous women giving birth (p-value = 0.000 < ?: 0.05). This indicates that the combination of the Slow Deep Breathing technique and lavender aromatherapy influences reduces the intensity of labor pain during the first active phase in primiparous women giving birth
Factors Associated With Undernutrition In Children in Tanjung Raya Village, Teluk Dalam District Simeulue District
Authors: Us Hafsah , Sembiring Julina Br , Safitri Mey Elisa
Published: August 2024

Based on data from the World Health Organization (WHO) in 2018, 49% of the 10.4 million deaths of children under five in developing countries were related to malnutrition. It is recorded that around 50% of children under five in Asia suffer from malnutrition (UNICEf, 2018). Nationally, the prevalence of malnutrition and malnutrition is still fluctuating. Objective: To determine the factors associated with poor nutrition in toddlers in Tanjung Raya Village, Teluk Dalam District, Simeulue Regency in 2023. Method: The research design used an analytical survey with a cross sectional approach. The population used was all mothers who had toddlers in Tanjung Raya Village, Teluk Dalam District, Simeulue Regency. The sampling technique used total sampling, namely 43 respondents. The data instrument used was a questionnaire that was distributed and filled in directly by respondents. Data analysis used the chi-square test with significance ?=0.05. Results: The chi-square test shows that there is a relationship between maternal knowledge and malnutrition with p-value = 0.002, there is a relationship between maternal attitudes and malnutrition with p-value = 0.009, there is a parenting pattern with undernutrition with p-value = 0.005. Conclusion: There is a relationship between maternal knowledge, attitudes and parenting patterns and malnutrition among toddlers in Tanjung Raya Village, Teluk Dalam District, Simeulue Regency in 2023. The results of this research are expected to be a reference for improving knowledge, attitudes and parenting patterns of mothers with malnutrition in toddlers
Factors Associated with Smoking Habits in Rt 11, 25 and 35 Paal Merah Village Paal Merah I Health Center Work Area Jambi City
Authors: Dalil Muhammad , Sianipar Sri Natalia , Ramadani Anisa Femilia , Rahayu Putri , Varid M. Raihan Octario , Amir Andy
Published: August 2024

Smoking habits are a fundamental health problem in various countries and the increasing number of people who smoke so that the negative impact is increasing. This type of research is quantitative analytic with a Cross Sectional study design using primary data PIS-PK questionnaire with a population of Rt 11, 25 and 35 Paal Merah Village, there is also a sample size of 100 people. Calculation of sample size using random sampling data analysis was carried out by frequency analysis, bivariate chi square analysis. Peeltiian results show the age variable there is no relationship between age and smoking habits. Education level has no relationship with smoking behavior with OR 0.575. Socioeconomic level has no relationship with smoking behavior with OR 0.383. Gender variable has no relationship with smoking behavior. In conclusion, there is no significant relationship between age, education level, socioeconomic level, and gender with smoking habits. for health workers in the Paal Merah 1 Puskesmas work area to increase educational and counseling efforts to the community regarding the dangers of smoking and the importance of maintaining health.
Risk Factors for Pre-Eclampsia in Pregnant Women at RSUD dr. ABDUL Rivai Berau
Authors: Dewi Suci Christina , Hadiningsih Eka Frenty , Masyita Gita , Risnawati Risnawati
Published: August 2024

Based on medical record data from RSUD dr. Abdul Rivai Berau is known to have 395 cases of pre-eclampsia pregnant women in January-October 2023. Risk factors that play an important role in the occurrence of pre-eclampsia: To determine risk factors for pre-eclampsia in pregnant women was age, parity, history contraceptives and multiple pregnancies. Type of research carried out was quantitative research with an analytical survey research design and a retrospective design. The population is all data pre-eclampsia cases in pregnant women January to October 2023 totaling 395 people, the Slovin formula sample of 199 people was obtained. The sampling technique uses simple random sampling. Data analysis using ch square. Age not at risk 57.8%, multigravida parity 55.3%, no history of using hormonal contraceptives 54.3%, no multiple pregnancies 51.8% and classification of mild pre-eclampsia 54.3%. There is a relationship between age and incidence of pre-eclampsia (p value = 0.009). There is a relationship between parity and incidence of pre-eclampsia (p value = 0.026). There is a relationship between a history of hormonal contraceptive use and the incidence of pre-eclampsia (p value = 0.011). There is a relationship between multiple pregnancies and incidence of pre-eclampsia (p value = 0.014). Age, parity, history of using hormonal contraceptives and multiple pregnancies as risk factors for pre-eclampsia in pregnant women. It is hoped RSUD dr. Abdul Rivai Berau provides health counseling or education to pregnant women preventing pre-eclampsia by providing material related to risk factors for pre-eclampsia in pregnant women along with their treatment and prevention
The Effect of Chewing Gum on the Recovery of Intestinal Peristalsis in Post Partum Sectio Caesarea Mothers
Authors: Ramasari Eka Alfiana , Purwanti Heni , Hadiningsih Eka Frenty , Sumiati Sumiati
Published: August 2024

Post-cesarean section surgery can cause a decrease in bowel movements. Dr. Data Hospital. Abdul Rivai, in August 2023 there were 66 caesarean section deliveries (51.2%) with a permanent decrease in intestinal peristalsis, namely 6 cases. Chewing gum is a form of sham feeding to stimulate the intestinal recovery process after surgery. Preliminary study at RSUD dr. Abdul Rivai Berau, it is known that there are cases of post-caesarean section mothers who experienced decreased intestinal peristalsis or did not increase intestinal peristalsis. To determine the effect of chewing gum on the recovery of intestinal peristalsis in post partum caesarean section mothers. Pre-experimental research type and One Group Pre-Test – Post-Test Design. The population is all post partum caesarean section mothers in the Postpartum Room at RSUD dr. There were 66 Abdul Rivai in Berau Regency in August 2023, based on the Lameshow formula with a sample of 35 people studied in December 2023. Instruments included a stethoscope, Xylitol gum and observation sheets. The sampling technique uses consecutive sampling. Data analysis used the Wilcoxon test. Frequency score of intestinal peristalsis before chewing gum in post partum caesarean mothers with a median of 2 times per minute and after chewing gum the median was 4. Obtained p value = 0.000 < ? : 0.05, meaning there is an effect of chewing gum on restoration of intestinal peristalsis. Chewing gum can improve the recovery of intestinal peristalsis in post partum caesarean section mothers.
The effectiveness of hydrocolloid dressing in post-operative wound healing: a narrative review
Authors: Hastuti Hediati , Nugraha Bambang Aditya , Annisa Hanun Nur , Aprilia Ilma , Maesaroh Imas , Karwati Karwati , Hasna Lathifah
Published: August 2024

Hydrocolloid dressings, recognized as advanced wound care solutions, enhance the healing process through their impermeable characteristics. This narrative review aims to evaluate the efficacy of hydrocolloid dressings in managing post-operative wounds. This research scrutinized literature from databases and search engines such as PubMed, Cochrane Library, and Google Scholar, focusing on publications from 2013-2023. Analysis of five selected articles revealed that hydrocolloid dressings not only effectively support the healing of surgical wounds but also offer prolonged usage and cost-efficiency. These benefits underscore the value of hydrocolloid dressings as a recommended practice for post-operative wound care among nurses and healthcare professionals.
The Effect of the Combination of Benson Relaxation and Lavender Aromatherapy on Pain in Post Sectio Caesarea Patients
Authors: Angriani Irma , Hartati Dwi , Risnawati Risnawati , Sulistyorini Chandra
Published: August 2024

Sectio caesarea is often associated with post-operative pain due to an incision in the stomach. Handling pain after cesarean section, apart from analgesics, requires non-pharmacological methods, including the Benson relaxation technique, which combines deep breathing relaxation and a person's belief system with lavender aromatherapy, which can release endorphins, thereby relieving pain. In a preliminary study at Dr. Abdul Rivai Hospital, there were ten mothers reporting pain in the area of ??the post-caesarean incision in the abdomen who had never used relaxation techniques, including Benson relaxation and lavender aromatherapy. This study aimed to determine the effect of Benson relaxation and lavender aromatherapy on pain in post-cesarean section patients. This study used pre-experimental and Group Pre-Test – Post-Test Design. A sample of post sectio caesarea patients became 38 people at Dr Abdul Rivai Hospital Berau. The instrument used the NRS scale. Data analysis used the Wilcoxon test. This study showed before being given the combination of Benson relaxation and lavender aromatherapy, the majority of post-cesarean section patients experienced severe pain, 76.3%, and after being given the combination of Benson relaxation and lavender aromatherapy, the majority of post-cesarean section patients experienced mild pain, 86.8%. Combining Benson relaxation and lavender aromatherapy affected pain in post-cesarean section patients (p-value = 0.000). This indicates that the combination of Benson relaxation and lavender aromatherapy is a non-pharmacological therapy that can reduce pain in post-cesarean section patients.
The Influence of Health Education on the Interest of TM III Pregnant Women in Screening for Congenital Hypothyroidism in Newborn Babies
Authors: Darmawan Shalsabila Febryanti , Hartati Dwi , Sulistyorini Chandra , Risnawati Risnawati
Published: August 2024

Congenital hypothyroidism screening is a screening to select babies who suffer from congenital hypothyroidism from babies who are not sufferers by taking 2-3 drops of blood from the baby's heel. A preliminary study at PMB Midwife Endang in December 2023 found data on the number of normal births of 32 people who underwent congenital hypothyroidism screening with 11 people. It shows that mothers still have low interest in doing Congenital hypothyroidism screening because, on average, they do not know about Congenital hypothyroidism screening, so they are less motivated. Mothers have never been given health education about Congenital hypothyroidism screening. This study aimed to determine the influence of health education on the interest of the third semester of pregnant women in screening for congenital hypothyroidism in newborns. This study used Pre-experimental with one group pre and post-test design. The population was 36 in the third semester of pregnant women at PMB Endang Yuniyati Napitupulu in January, with a sample of 30 people taken using a total sampling technique. The instrument was a questionnaire. Data analysis used the Wilcoxon test. This study showed that before being given health education, most respondents were not interested in doing congenital hypothyroidism screening on their babies (73.3%), and after being given health education, most respondents were interested in doing Congenital hypothyroidism screening on their babies (76.7% ). There was an influence of health education on the interest of the third-semester of pregnant women in screening for congenital hypothyroidism in newborns (p-value = 0.000 < ?: 0.05).
Quantification of the emesis scale (puqe-24) through giving ginger wedding to 1st trimester pregnant women
Authors: Sibero Jitasari Tarigan , Fitria Aida , Priyah Wiknish Banu
Published: August 2024

Nausea, vomiting or morning sickness is the most common symptom experienced in early pregnancy due to an imbalance in the hormones estrogen and progesterone. To determine the quantification of the emesis scale (PUQE-24) before being given Wedang Ginger at the Fina Sembing Clinic in Medan in 2023. To determine the quantification of the emesis scale (PUQE-24) after being given Wedang Ginger. To analyze and determine the effect of giving Wedang Ginger to reduce emesis gravidarum in Pregnant Women in the 1st Trimester. Using a quasi-experimental design with a one group pretest posttest design that has treatment. The sampling technique was purposive sampling, namely 10 respondents with all respondents given treatment, while the sample was taken from the entire population. The data analysis used in this research is univariate analysis and bivariate analysis with the Wilcoxon test. The research showed that pregnant women in the first trimester who experienced emesis gravidarum before and after giving ginger tea had a p value = 0.003 < 0.05, indicating that Ho would be rejected and Ha would be accepted. Conclusion: there is an effect of giving ginger tea to reduce emesis gravidarum in pregnant women in the first trimester at the Fina Sembiring Clinic, Medan. It is hoped that health workers can apply ginger tea to pregnant women in the first trimester who experience nausea and vomiting as an additional therapy to accompany conventional medicine for pregnant women.