bluuebunny/crossref_metadata_2025 huggingface dataset:
Faecal carriage of multidrug-resistant bacteria and associated risk factors: results from a point prevalence study
Authors: Grohs Patrick , Vilfaillot Aurélie , Zahar Jean Ralph , Barbut Frédéric , Frange Pierre , Casetta Anne , Moulin Véronique , Lawrence Christine , Baune Patricia , Bourgeois Cléo , Bouffier Axel , Laussucq Claudine , Sienzonit Lydia , Picard Simon , Podglajen Isabelle , Kassis-Chikhani Najiby
Published: August 2022

Objectives

Since 2003, incidences of carbapenemase-producing Gram-negative bacilli (CP-GNB) and vancomycin-resistant Enterococcus faecium (VRE) have steadily increased in France. We therefore conducted a point prevalence study to estimate carriage rates of CP-GNB, VRE and ESBL-producing Enterobacterales (ESBL-PE) and associated risk factors.

Methods

Between September 2019 and January 2020, all inpatients hospitalized on a given day in 11 teaching hospitals in the Paris urban area were eligible. Patient interviews and rectal swab screening results were recorded by dedicated nurses. The swabs were plated onto selective chromogenic media and processed using the GeneXpert® system.

Results

Of 2396 patients, 364 (15.2%) yielded at least one multiresistant bacterial isolate, including 29 CP-GNB carriers (1.2%), 13 VRE carriers (0.5%) and 338 ESBL-PE carriers (14%). In 15 patients (4.4% of ESBL-PE carriers and 36.6% of CP-GNB/VRE carriers), concomitant CP-GNB/VRE and ESBL-PE carriage was observed. In 7/29 CP-GNB and 7/13 VRE carriers, carbapenemase production and vanA in the screening samples was only detected with Xpert® tests. The OXA-48 gene was predominant in 13/34 CP-GNB isolates from 29 carriers. From the 338 ESBL-PE carriers, 372 isolates were recovered, mainly Escherichia coli (61.2%). Among 379 children, 1.1% carried a CP-GNB/VRE strain, and 12.4% carried an ESBL strain. Previous hospitalization outside mainland France, previous antimicrobial treatment and previous ESBL-PE carriage were the main risk factors associated with CP-GNB and/or VRE carriage.

Conclusions

The low CP-GNB and VRE prevalence likely reflects the French policy to limit intrahospital spread of CP-GNB and VRE strains.
Outcomes Following Use of Negative-Pressure Wound Therapy Over Autologous Meshed and Non-Meshed Skin Grafts
Authors: Sweitzer Keith , Tomtschik Julia , Butterfield James , Bell Derek
Published: August 2022

Negative-pressure wound therapy (NPWT) over split thickness skin grafts can control exudate, decrease infection rates, and improve revascularization. However, no study specifically addresses differences in outcomes between meshed/perforated and non-meshed autologous skin grafts dressed with NPWT. Through retrospective chart review, patients undergoing autologous split thickness skin grafting with a NPWT dressing for any burn injury over a 10-month period were identified. Data on etiology, graft take, meshed/perforated or non-meshed graft, graft size, and seroma/hematoma incidence were collected. Our study included 123 patients who had STSG with NPWT and consisted of 57% males, 57% Caucasian, and an average age of 41. Burn injury etiologies consisted of scald (55%), chemical (25%), flame (15%), and contact (5%). Average 2nd degree TBSA in our cohort was 2.34%, 3rd degree TBSA 4.50%, and total TBSA 5.35%. 66.7% of patients received non-meshed grafts, and these patients had an average graft area of 76.5 cm2. 33.3% of patients received meshed grafts, with an average graft area of 163.5 cm2. Non-meshed burn grafts were significantly smaller than meshed grafts (P = .04). There was 100% graft take and 0% seroma/hematoma formation in all patients. Data was analyzed using an unpaired student’s T test and ANOVA testing. There were no statistically significant differences in patient demographics, or burn etiology. There exist many options for dressings after repair of burn injuries, each with its own unique advantages. There were, however, no differences in graft take or incidence of seroma/hematoma formation using a NPWT dressing over autologous meshed grafts vs non-meshed grafts. Our data shows that NPWT use as a bolster dressing is safe and efficacious overlying meshed skin grafts and non-meshed grafts.
Bone Lesions Detected on Breast MRI: Clinical Outcomes and Features Associated With Metastatic Breast Cancer
Authors: Corines Marina J , Coffey Kristen , Dou Eda , Lobaugh Stephanie , Zheng Junting , Hwang Sinchun , Feigin Kimberly
Published: August 2022

Objective

To determine prevalence and frequency of malignancy among bone lesions detected on breast MRI and to identify clinical and imaging features associated with bone metastases from breast cancer (BC), as bone lesions are suboptimally evaluated on breast imaging protocols and can present a diagnostic challenge.

Methods

This IRB-approved retrospective review of breast MRIs performed from June 2009 to June 2018 identified patients with bone lesions. Demographic, clinical, and MRI features were reviewed. Clinical outcome of bone lesions was determined based on pathology and/or additional diagnostic imaging. All benign lesions had ≥2 years of imaging follow-up. Statistics were computed using Fisher exact and Wilcoxon rank sum tests.

Results

Among all patients with breast MRI, 1.2% (340/29 461) had bone lesions. Of these, 224 were confirmed benign or metastatic BC by pathology or imaging follow-up, with 70.1% (157/224) benign and 29.9% (67/224) metastatic. Bone metastases were associated with BC history (P < 0.001), with metastases occurring in 58.2% (53/91) of patients with current BC, 17.9% (14/78) patients with prior BC, and 0.0% (0/55) without BC. Bone metastases were associated with invasive and advanced stage BC and, on MRI, with location in sternum, ribs, or clavicles, larger size, multiplicity, and T1 hypointensity (all P < 0.01 in tests of overall association).

Conclusion

Of clinically confirmed breast MRI–detected bone lesions, 30% were bone metastases; all were detected in patients with current or prior BC. Metastases were associated with advanced stage, invasive carcinoma, larger lesion size, multiplicity, low T1 signal, and non-spine location.
Evaluation of membrane quality and entrance pressure of oil-based mud at elevated temperatures
Authors: Hashem Shahad , AL-Bazali Talal , Garrouch Ali , Owayed Jalal
Published: August 2022

This study fully explored the impact of temperature on the membrane quality of oil-based mud (OBM) using static gravimetric measurements, membrane efficiency and entrance pressure tests. More than 30 shale samples were used to assess the membrane behavior of several OBMs under elevated temperatures. Results suggested that OBM acted as a semi-permeable membrane at low temperatures (25–55˚C) since ion flow out of OBM and into shale was restricted despite the existence of a large ionic concentration gradient, while water flowed freely out of shale and into OBM because of the existence of a chemical potential difference. For temperatures higher than 55˚C, relatively higher ion flux into shale and slightly lower water flow out of shale was observed. Excessive heat may have possibly destabilized or even destroyed the emulsifier's structure that serves as a mechanism through which OBM performs as a semi-permeable membrane. The instability of OBM's emulsifier was further confirmed through entrance pressure testing where an appreciable reduction in entrance pressure of OBM was measured at high temperatures.
A Consistent and Robust Test for Autocorrelated Jump Occurrences
Authors: Kwok Simon
Published: August 2022

We develop a nonparametric test for the temporal dependence of jump occurrences in the population. The test is consistent against all pairwise serial dependence, and is robust to the jump activity level and the choice of sampling scheme. We establish asymptotic normality and local power property for a rich set of local alternatives, including both self-exciting and/or self-inhibitory jumps. Simulation study confirms the robustness of the test and reveals its competitive size and power performance over existing tests. In an empirical study on high-frequency stock returns, our procedure uncovers a wide array of autocorrelation profiles of jump occurrences for different stocks in different time periods.
The Imperturbable Seriousness of the Circus Buffoon: The Shakespearean Clown on the Threshold of Modern Comedy
Authors: Andersson Peter K
Published: August 2022

Around the middle of the nineteenth century, there arose a type of circus performer in England called ‘Shakespearean clowns’. These clowns constituted a transitory figure between the age of Georgian pantomime clowns and the establishment of the typical circus clown in the later part of the century. One of the more neglected representatives of the genre was James Clement Boswell, who enjoyed a brief period of success in England before becoming a sensation in Paris during the 1850s. Although he was universally praised, his clowning also evoked bafflement. This article studies reviews of and periodical articles on Boswell in order to get a picture of his performances and clown persona, and of how critics perceived him and turned him into an example of the melancholy clown trope. The resistance that Boswell’s act and persona offered to the writers, however, illustrates that he was part of a change in the figure of the clown from its early nineteenth century incarnation to the twentieth-century clown and comic. Boswell’s clowning prefigures the irony and deadpan comedy that would become more prevalent in modern comedy. He is also illustrative of the increasing detachment of the clown figure from representations of a social reality, and the creation of the modern circus clown as an essentially unreal character that epitomizes a separate outlook on life.
H i content of massive red spiral galaxies observed by FAST
Authors: Wang Lan , Zheng Zheng , Hao Cai-Na , Guo Rui , Li Ran , Qian Lei , Xie Lizhi , Shi Yong , Zou Hu , Cao Yixian , Chen Yanmei , Xia Xiaoyang
Published: August 2022

A sample of 279 massive red spirals was selected optically by Guo et al., among which 166 galaxies have been observed by the ALFALFA survey. In this work, we observe H i content of the rest 113 massive red spiral galaxies using the Five-hundred-meter Aperture Spherical radio Telescope (FAST). 75 of the 113 galaxies have H i detection with a signal-to-noise ratio (S/N) greater than 4.7. Compared with the red spirals in the same sample that have been observed by the ALFALFA survey, galaxies observed by FAST have on average a higher S/N, and reach to a lower H i mass. To investigate why many red spirals contain a significant amount of H i mass, we check colour profiles of the massive red spirals using images observed by the DESI Legacy Imaging Surveys. We find that galaxies with H i detection have bluer outer discs than the galaxies without H i detection, for both ALFALFA and FAST samples. For galaxies with H i detection, there exists a clear correlation between galaxy H i mass and g-r colour at outer radius: galaxies with higher H i masses have bluer outer discs. The results indicate that optically selected massive red spirals are not fully quenched, and the H i gas observed in many of the galaxies may exist in their outer blue discs.
Statistical properties of cataclysmic variables in the local galactic disc: a joint analysis of Gaia and XMM–Newton data
Authors: Xu Xiao-jie , Wang Q Daniel , Li Xiangdong
Published: August 2022

Cataclysmic variables (CVs) represent a key evolutionary phase of many low-mass stellar binaries and appear to collectively dominate the galactic X-ray background above ∼1 keV. Statistical properties of CVs, however, remain poorly understood, even in the solar neighbourhood. We aim to obtain an X-ray luminosity-complete sample of local CVs whose distances put them within three volumes. Here we present a pilot investigation on the X-ray and optical properties of local CVs or their candidates, mainly by cross-correlating the 3XMM DR8 and Gaia DR2 source catalogues. We first examine a nearly complete sample of CVs within 150 pc by characterizing their X-ray luminosity, X-ray to Gaia G-band flux ratio, and X-ray hardness ratio distributions, as well as their locations in the Gaia colour–magnitude diagram. We show that these distributions of this very local sample are consistent with those of a CV sample obtained at distances between 150 and 300 pc. We also present a catalogue of 15 new CV candidates within 500 pc based primarily on their X-ray to Gaia G-band flux ratios. The X-ray luminosities of these candidates are between 1029 to several 1031 erg s−1, and their stacked X-ray spectrum can be well described by a multitemperature optically thin thermal plasma model with a maximum temperature $T_{\rm max}=7.5^{+6.3}_{-2.4}$ keV. These properties are consistent with those of the very local CVs. In particular, one of the CV candidates is within 150 pc, indicating that a considerable number of local CVs are yet detected. These results provide a base for a more complete statistical understanding of CVs and their quantitative contribution to the galactic X-ray background.
The role of supernova convection for the lower mass gap in the isolated binary formation of gravitational wave sources
Authors: Olejak Aleksandra , Fryer Chris L , Belczynski Krzysztof , Baibhav Vishal
Published: August 2022

Understanding the astrophysical phenomena involving compact objects requires an insight about the engine behind the core-collapse supernovae (SNe) and the fate of the stellar collapse of massive stars. In particular, this insight is crucial in developing an understanding of the origin and formation channels of the growing populations of the detected black hole–black hole, black hole–neutron star, and neutron star–neutron star mergers. The time-scale of convection growth may have a large effect on the strength of SN explosion and therefore also on the mass distribution of stellar remnants. We adopt new formulas for the relation between the pre-SN star properties and their remnants and check how they impact the population of double compact object (DCO) mergers formed via the isolated binary evolution. The new formulas give one the ability to test a wide spectrum of assumptions on the convection growth time. In particular, the different variants allow for a smooth transition between having a deep mass gap and a remnant mass distribution filled by massive neutron stars and low-mass black holes. We present the distribution of masses, mass ratios, and the local merger rate densities of DCO for the different variants of new formulas and test them together with different approaches to other highly uncertain processes. We find that the mass distribution of DCO mergers is sensitive to the adopted assumption on the SN convection growth time-scale up to $m_1+m_2 \lesssim 35 \, \mathrm{M}_{\odot }$. Between the two extreme tested variants the probability of compact object formation within the mass gap may differ by up to approximately two orders of magnitude.
Possible non-thermal origin of the hard X-ray emission in the merging galaxy cluster SPT-CL J2031−4037
Authors: Mirakhor M S , Walker S A , Runge J , Diwanji P
Published: August 2022

Non-thermal emission from clusters of galaxies at the high-energy X-ray regime has been searched with various instruments, but the detection significance of this emission has yet been found to be either marginal or controversial. Taking advantage of NuSTAR’s unique capability to focus X-rays in the hard energy band, we present a detailed analysis of 238 ks NuSTAR observations of the merging galaxy cluster SPT-CL J2031−4037, searching for non-thermal inverse Compton emission. Our spectral analysis of SPT-CL J2031−4037 shows a possibility that the hard X-ray emission of the cluster can be described by a non-thermal component, though we cannot completely rule out a purely thermal origin for this hard emission. Including the statistical and systematic uncertainties, our best model fit yields a 20–80 keV non-thermal flux of $3.93_{-1.10}^{+1.24} \times 10^{-12}$ erg s−1 cm−2. The estimated non-thermal flux is comparable to those found in other galaxy clusters using NuSTAR and other X-ray instruments. Using this non-thermal flux with the existing radio data of the cluster, we estimate a volume-averaged magnetic field strength in the range of around 0.1–0.2 µG.
The effect of local Universe constraints on halo abundance and clustering
Authors: Hutt Maxwell L , Desmond Harry , Devriendt Julien , Slyz Adrianne
Published: August 2022

Cosmological N-body simulations of the dark matter component of the universe typically use initial conditions with a fixed power spectrum and random phases of the density field, leading to structure consistent with the local distribution of galaxies only in a statistical sense. It is, however, possible to infer the initial phases which lead to the configuration of galaxies and clusters that we see around us. We analyse the CSiBORG suite of 101 simulations, formed by constraining the density field within 155 Mpc h−1 with dark matter particle mass 4.38 × 109 M⊙, to quantify the degree to which constraints imposed on 2.65 Mpc h−1 scales reduce variance in the halo mass function and halo–halo cross-correlation function on a range of scales. This is achieved by contrasting CSiBORG with a subset of the unconstrained Quijote simulations and expectations for the ΛCDM average. Using the FOF, PHEW, and HOP halofinders, we show that the CSiBORG suite beats cosmic variance at large mass scales (≳1014 M⊙ h−1), which are most strongly constrained by the initial conditions, and exhibits a significant halo–halo cross-correlation out to ∼30 Mpc h−1. Moreover, the effect of the constraints percolates down to lower mass objects and to scales below those on which they are imposed. Finally, we develop an algorithm to ‘twin’ haloes between realizations and show that approximately 50 per cent of haloes with mass greater than 1015 M⊙ h−1 can be identified in all realizations of the CSiBORG suite. We make the CSiBORG halo catalogues publicly available for future applications requiring knowledge of the local halo field.
An edge-on orbit for the eccentric long-period planet HR 5183 b
Authors: Venner Alexander , Pearce Logan A , Vanderburg Andrew
Published: August 2022

The long-period giant planet HR 5183 b has one of the most extreme orbits among exoplanets known to date, and represents a test for models of their dynamical evolution. In this work, we use Hipparcos–Gaia astrometry to measure the orbital inclination of this planet for the first time and find $i=89.9^{+13.3\circ }_{-13.5}$, fully consistent with edge-on. The long orbital period and high eccentricity of HR 5183 b are supported by our results, with $P=102^{+84}_{-34}$ yr and e = 0.87 ± 0.04. We confirm that HR 5183 forms a physically bound binary with HIP 67291 at a projected separation of 15 400 AU, and derive new constraints on the orbit of this pair. We combine these results to measure the mutual inclination between the planetary and binary orbits; we observe significant evidence for misalignment, which remains even after accounting for bias of the prior towards high mutual inclinations. However, our results are too imprecise to evaluate a recent prediction that the mutual inclination should reflect the formation history of HR 5183 b. Further observations, especially the release of the full Gaia astrometric data, will allow for improved constraints on the planet-binary mutual inclination. $52 \pm 16\ \hbox{per cent}$ of known planets with eccentricities e ≥ 0.8 are found in multiple star systems, a rate that we find to be greater than for the overall planet population to moderate significance (p = 0.0075). This supports the hypothesis that dynamical interactions with wide stellar companions plays an important role in the formation of highly eccentric exoplanets.
Triboelectric nanogenerators as wearable power sources and self-powered sensors
Authors: Pu Xiong , Zhang Chi , Wang Zhong Lin
Published: August 2022

Smart wearable technologies are augmenting human bodies beyond our biological capabilities in communication, healthcare and recreation. Energy supply and information acquisition are essential for wearable electronics, whereas the increasing demands in multifunction are raising the requirements for energy and sensor devices. The triboelectric nanogenerator (TENG), proven to be able to convert various mechanical energies into electricity, can fulfill either of these two functions and therefore has drawn extensive attention and research efforts worldwide. The everyday life of a human body produces considerable mechanical energies and, in the meantime, the human body communicates mainly through mechanical signals, such as sound, body gestures and muscle movements. Therefore, the TENG has been intensively studied to serve as either wearable sources or wearable self-powered sensors. Herein, the recent finding on the fundamental understanding of TENGs is revisited briefly, followed by a summary of recent advancements in TENG-based wearable power sources and self-powered sensors. The challenges and prospects of this area are given as well.
Time to Culture Conversion of Bedaquiline and High-Dose Isoniazid for Drug-Resistant Tuberculosis
Authors: Walsh Kathleen F , Vilbrun Stalz Charles , Souroutzidis Ariadne , Ellis Joshua , Delva Sobiesyke , Joissaint Guy , Dupnik Kathryn M , Joseph Patrice , Pape Jean W , Koenig Serena P
Published: August 2022

Patients with multidrug-resistant tuberculosis who received regimens containing high-dose isoniazid (INHHD) had similar time to culture conversion and treatment outcomes as patients who received regimens with bedaquiline. INHHD is an inexpensive and safe medication that may contribute additive efficacy in combination regimens.
Harm, Baselines, and the Worse than Nothing Account
Authors: Immerman Daniel
Published: August 2022

Harm is one of the central concepts of ethics, so it would be good to offer an account of it. Many accounts appeal to a baseline: They say that you harm someone if you leave them worse off than in the baseline case. In this paper, I draw some lessons regarding what counts as an appropriate baseline and explore what these general lessons reveal about the nature of harm. In the process of so doing, I argue that a certain rarely discussed account of harm—the worse-than-nothing account of harm—does a particularly good job of identifying a baseline. This account says you harm someone if you leave them worse off than if you had done nothing to them.
Direct payments and on-farm employment: Evidence from a spatial regression discontinuity design
Authors: Zimmert Franziska , Zorn Alexander
Published: August 2022

Direct payments are regarded as a suitable instrument to safeguard jobs in the agricultural sector. However, empirical findings to date do not unambiguously support this expectation. We further empirically investigate this research question on dairy farms with a focus on family work. Using a spatial regression discontinuity design, we rely upon selection on unobservables assumptions. The Swiss direct payments system creates a discontinuous jump near the border of agricultural production zones for the amount of public subsidies a farm receives. Using two-stage least squares (TSLS) to estimate the policy-relevant effect, we find that an additional CHF 50,000 can generate a job for a female family worker in the dairy sector. Male employment is not affected. These results show that direct payments can safeguard traditional family farming.
Scutellaria barbata D. Don inhibits cervical cancer cell proliferation, migration, and invasion via miR-195-5p/LOXL2 axis
Authors: Xue Shouyu , Geng Aimin , Lian Ting , Liu Yun
Published: August 2022

Background

Scutellaria barbata D. Don (SB) is a widely used herbal medicine in China, with various pharmacological effects such as anti-oxidation, anti-inflammation, and anti-cancer. This work is aimed to investigate the tumor-suppressive effect of SB in cervical cancer (CC) and to identify its underlying mechanisms.

Methods and materials

CC cell lines (HeLa and HT-3) were treated with different concentrations of SB chloroform extract (ECSB) (0, 0.2, 0.5 mg/ml). MiR-195-5p and LOXL2 mRNA expression in CC cell lines and tissue samples was detected by quantitative real-time polymerase chain reaction. Cell counting kit-8 experiment was utilized to examine cell viability; TUNEL assay and Transwell experiment was executed to examine cell apoptosis, migration, and invasion. Western blotting experiments were implemented to detect LOXL2 protein expression. Bioinformatics and dual-luciferase reporter gene experiment were executed to examine the binding relationship between miR-195-5p and LOXL2.

Results

ECSB repressed the viability, migration, and invasion of HeLa and HT-3 cells, and promoted cell apoptosis in a dose-dependent manner. MiR-195-5p was remarkably under-expressed in CC tissues and cells, and ECSB up-regulated miR-195-5p expression. MiR-195-5p inhibitors partially counteracted the suppressive effects of ECSB on the malignant phenotypes of HeLa and HT-3 cells. LOXL2 was a downstream target of miR-195-5p, and ECSB up-modulated LOXL2 expression by specifically repressing miR-195-5p.

Conclusion

SB restrains CC cell proliferation and metastasis and promotes cell apoptosis via miR-195-5p/LOXL2, which may be a potential therapeutic agent for CC treatment.
Relationship between the mode of delivery, morbidity and mortality in preterm infants
Authors: Karayel Eroglu Hulya , Gulasi Selvi , Mert M Kurthan , Cekinmez Eren K
Published: August 2022

Background

The aim of the study, to evaluate the relationship between mode of delivery and preterm morbidities and mortality, who born ≤34 weeks of gestation within 1 year.

Materials and methods

Babies were divided into two groups as who were born by cesarean section (CS) and vaginal delivery (VD) between March 2019 and March 2020. Infants born at ≤28 weeks were also analyzed.

Results

The rate of CS delivery was 76% (378) in the whole group and 73% (115) in the babies of ≤28 gestational weeks. The most common maternal factor causing CS was preeclampsia (25%). The antenatal corticosteroid (ACS) application rate was 30% (152) in the whole group and 30% (45) in infants of ≤28 weeks. Rate of babies with an Apgar score of <5 at 5th min, asphyxia, multiple organ failure, development of severe respiratory distress syndrome, severe intraventricular hemorrhage (IVH) and mortality were significantly increased in infants born VD (for all p < 0.05). Mortality was significantly higher when gestational age was ≤28 weeks, birth weight was ≤1500 g and ACS was not administered (p < 0.001 for all).

Conclusion

Mortality, severe IVH, neonatal asphyxia and multiple organ failure were found to be higher in those who were born by VD. These findings suggest that these results were due to inadequate prenatal care and follow-up and lack of ACS.
Anterior total hip arthroplasty outcomes in the treatment of femoral neck fractures: a retrospective cohort study
Authors: Crist Brett D. , Surma Tyler J. , Esposito Ennio Rizzo , Matera Julia R , Worley John R. , Rund Joseph M. , Cook James L.
Published: August 2022

Background:

A prior study reported a 22% complication rate using the direct anterior (DA) approach for total hip arthroplasty (THA) in the displaced femoral neck fracture population. This seemed contrary to institutional experience; this study investigated outcomes and complication rates for DA THA used in the displaced femoral neck fracture population.

Methods:

This retrospective cohort study identified and analyzed patients undergoing DA THA for a femoral neck fracture over a 4-year period at a level 1 academic trauma center who were treated by an experienced senior surgeon.

Results:

Thirty-seven patients (21 women, 16 men) were included in the final analysis. The mean age was 70.9 (SD 11.30) years. All patients received cementless components. One (2.7%) intraoperative greater trochanteric fracture and one (2.7%) in-hospital mortality were recorded. Average follow-up was 10.46 mo (range 0 to 53 mo). There were no reported postoperative periprosthetic fractures, dislocations, or revision arthroplasties. No deep venous thromboses or pulmonary embolisms occurred within 90 days of surgery. There were two (5%) deep infections. The overall complication rate was 8.1%. Patient-reported outcomes were available for 32 patients. Visual Analog Scale pain was 2.59 at 6 wk average compared with 1.83 at 12 mo. Hip Disability and Osteoarthritis Outcome Score Quality of Life at 6 wk averaged 46.69 compared with 59.24 at 12 mo.

Conclusions:

The direct anterior approach for THA can be a safe option for experienced surgeons.

Level of Evidence:

Level III.
Evaluating Information About Osteochondritis Dissecans Shared Across Social Media Platforms
Authors: Gussner Anna , Baskar Danika , Rohde Matt , Ganley Ted , Shea Kevin
Published: August 2022

Background:

With the rise of social media, patients are using a variety of online resources to gather information about medical conditions and connect with others for support. Osteochondritis dissecans (OCD) occurs most commonly among children and adolescents, necessitating early diagnosis and management. The purpose of this study is to evaluate content on social media about OCD to quantify the reach of information shared and themes of discussion surrounding this condition.

Methods:

A search was performed across Facebook, Instagram, YouTube, and TikTok using the term “osteochondritis dissecans” to identify information shared related to this topic which was then analyzed based on engagement using number of followers, posts, and/or views.

Results:

Facebook groups provided a forum for online support and information sharing among patients with OCD and their families. The 4 identified groups had a cumulative following of over 4000 people with posts that shared personal recovery stories, solicited treatment advice, and provided updates on patient progress. Review of related Instagram hashtags revealed over 4500 posts, many of which shared personal accounts of living with OCD. The top 5 most viewed YouTube videos collectively had over 189,000 views and were focused on educational information about OCD, relevant surgical techniques, and pertinent anatomy. The top 3 OCD-related TikTok hashtags had over 4 million total views centered on factual knowledge and sharing changes before and after surgical treatment.

Conclusion:

Patients with OCD and their families seek information about their condition and treatment on online sources including social media. Although social media provides a supportive community to share and receive advice, the quality of information shared in these groups is a subject for concern. Increasing physician involvement and awareness of the information shared across social media platforms may improve accuracy of information and content available to patients.

Clinical Relevance:

It is important for physicians treating patients with OCD to be aware of all sources of information and support, including content shared on social media as these platforms allow for the sharing of personal stories, recommendations for treatment, and educational content.
Effectiveness of ultrasound for endometriosis diagnosis
Authors: Chen-Dixon Katie , Uzuner Cansu , Mak Jason , Condous George
Published: August 2022

Purpose of review

Endometriosis is a chronic benign gynaecological condition characterized by pelvic pain, subfertility and delay in diagnosis. There is an emerging philosophical shift from gold standard histopathological diagnosis through laparoscopy to establishing diagnosis through noninvasive imaging.

Recent findings

The ENZIAN classification system was updated in 2021 to be suitable for both diagnostic imaging and laparoscopy. The accuracy of transvaginal ultrasound (TVUS) in diagnosing endometriosis varies depending on location of the lesion. A recent international pilot study found that when ultrasound is performed in accordance with the IDEA consensus, a higher detection of deep endometriosis is seen, with an overall sensitivity of 88% and specificity of 79% compared with direct surgical visualization.

Although ultrasound can detect adenomyosis, deep endometriosis and endometriomas, it is not possible to reliably detect superficial endometriosis. In the instance of a negative ultrasound with persistence of symptoms despite medical therapy, laparoscopy should be considered for diagnosis and treatment.
Pharmacologic therapeutic options for sexual dysfunction
Authors: Burton Claire S. , Mishra Kavita
Published: August 2022

Purpose of review

Sexual problems are reported by up to 45% of individuals assigned female at birth. Although sexual function is a complex biopsychosocial construct, there are a number of pharmacologic treatment options aimed at addressing the changing vaginal hormonal milieu in postmenopausal individuals and moderating the excitatory and inhibitory aspects of the central nervous system in those with hypoactive sexual desire disorder.

Recent findings

The last decade has seen an increase in the number and type of pharmacologic treatment options for dysfunction primarily associated with menopause and hypoactive sexual desire disorder. Recent publications and systematic reviews have strengthened the safety data of existing FDA-approved medications as well as off-label therapies.

Pharmacologic treatment with local estrogen and testosterone replacement in postmenopausal individuals and with centrally-acting therapies such as flibanserin, bremelanotide, and testosterone in premenopausal individuals assigned female at birth are safe and can be used to improve sexual desire and sexual satisfaction.
Central Nervous System Fungal Infections in Children With Leukemia and Undergoing Hematopoietic Stem Cell Transplantation: A Retrospective Multicenter Study
Authors: Karaman Serap , Kebudi Rejin , Kizilocak Hande , Karakas Zeynep , Demirag Bengu , Evim Melike S. , Yarali Nese , Kaya Zuhre , Karagun Barbaros S. , Aydogdu Selime , Caliskan Umran , Ayhan Aylin C. , Bahadir Aysenur , Cakir Betul , Guner Burcak T. , Albayrak Canan , Karapinar Deniz Y. , Kazanci Elif G. , Unal Ekrem , Turkkan Emine , Akici Ferhan , Bor Ozcan , Vural Sema , Yilmaz Sebnem , Apak Hilmi , Baytan Birol , Tahta Neryal M. , Güzelkucuk Zeliha , Kocak Ulker , Antmen Bulent , Tokgöz Huseyin , Fisgin Tunc , Özdemir Nihal , Gunes Adalet M. , Vergin Canan , Unuvar Aysegul , Ozbek Namik , Tugcu Deniz , Bay Sema B. , Tanyildiz Hikmet G. , Celkan Tiraje
Published: August 2022

Background:

Central nervous system fungal infections (CNSFI) are seen in patients with hematologic malignancies and have high morbidity and mortality. Because of their rarity, there is limited data on CNSFI in children with no established treatment protocols or guidelines.

Materials and Methods:

In this multicenter retrospective study, 51 pediatric patients with leukemia, 6 of whom had undergone bone marrow transplantation, with proven or probable CNSFI were evaluated. Fungal infections were defined as proven or probable based on European Organisation for Research and Treatment of Cancer criteria. Proven CNSFI was diagnosed by appropriate central nervous system (CNS) imaging or tissue sample findings in combination with positive microbiological results of cerebrospinal fluid. A positive culture, microscopic evidence of hyphae, a positive result of the galactomannan assays are defined as positive microbiological evidence. Probable CNSFI was defined as appropriate CNS imaging findings together with proven or probable invasive fungal infections at another focus without CNS when there is no other explanatory condition. Data was collected by using the questionnaire form (Supplemental Digital Content 1, http://links.lww.com/JPHO/A541).

Results:

Seventeen patients had proven, 34 patients had probable CNSFI. Headaches and seizures were the most common clinical findings. The median time between the onset of fever and diagnosis was 5 days. The most common fungal agent identified was Aspergillus. Sixteen patients received single-agent, 35 received combination antifungal therapy. Surgery was performed in 23 patients. Twenty-two patients (43%) died, 29 of the CNSFI episodes recovered with a 20% neurological sequelae.

Conclusion:

CNSFIs should be considered in the differential diagnosis in patients with leukemia and refractory/recurrent fever, headache, neurologicalocular symptoms, and a radiologic-serological evaluation should be performed immediately. Early diagnosis and prompt management, both medical and surgical, are essential for improving clinical outcomes.
Prosthesis use among individuals with lower limb amputation in Bangladesh
Authors: Al Imam Mahmudul Hassan , Kader Manzur , Islam Rangila , Alamgir Hasnat
Published: August 2022

Objective:

This study aimed to assess factors related to prostheses use among individuals with lower limb amputation in Bangladesh.

Methods:

Data related to prosthesis use, functional capabilities (as measured with the Locomotor Capabilities Index [LCI]), and user satisfaction were collected using telephone interviews between January 2014 and October 2016. Descriptive and regression analyses were performed.

Results:

This study involved 183 participants (89.6% male); the mean (SD) age was 49.5 (10.7) years. Most of the participants (95.6%) used prostheses daily, and the mean (SD) duration of use was 7.0 (4.1) hours per day. The mean (SD) basic LCI score, advanced LCI score, and total LCI score were 25.1 (4.9), 20.8 (8.3), and 45.9 (12.2), respectively. Among them, 36.7% were dissatisfied with the weight of the prosthesis. Having a below knee amputation (odds ratio 2.6 and confidence interval 1.3, 5.3) and absence of comorbidities (odds ratio 2.1; confidence interval 1.0, 4.4) were associated significantly with an increased use of prosthesis.

Conclusion:

Factors such as weight of the prosthesis, amputation level, and presence of comorbidities are important considerations while planning for prosthetic rehabilitation and optimize utilization of the prosthetic devices.
Analysis of Risk Factors for Vulnerable Plaque Formation and Pathogenic in Carotid Artery
Authors: Bao Jingang , Tong Xiaoguang , Wu Rile , Yun Qiang
Published: August 2022

Objectives:

The formation of vulnerable carotid artery plaque may be closely related to a single factor or caused by multiple factors. This paper discusses the pathogenic risk factors for vulnerable plaque in patients with severe internal carotid artery (ICA) stenosis who received endarterectomy through regression analysis.

Materials and Methods:

A total of 98 patients with a complete clinical and laboratory assessment underwent carotid endarterectomy. Metabolic syndrome (MetS) and MetS components, ICA plaque thickness and ICA peak systolic velocity, previous ischemic stroke or transient ischemic attack (TIA), and other risk factors were included in the pathogenic risk factor for vulnerable plaque. Univariate logistic regression analysis was used to determine vulnerable carotid plaque risk factors. If P<0.2, it was considered potential confounders. Binary logistic regression model was controlled for potential confounders.

Results:

Among the 98 patients, stable carotid plaques 38 (39%) and unstable carotid plaques 60 (61%), male 76 (77.6%) and female 22 (22.4%), and Han Chinese 68 (68.4%) and Mongols 30 (30.6%). Univariate logistic regression to P<0.2 has 6 risk factors, which are previous ischemic stroke or TIA, ICA peak systolic velocity, ICA plaque thickness, body mass index, total cholesterol, and alcohol consumption. The significant result of the binary logistic regression analysis was the previous ischemic stroke or TIA (OR=4.52; 95% CI, 1.67–12.09), P=0.003 and ICA peak systolic velocity (OR=1.01; 95% CI, 1.00–1.02), P=0.014.

Conclusions:

The patients with previous ischemic stroke or TIA and higher ICA peak systolic velocity are associated with vulnerable plaque pathogenic features. There is no obligatory association between MetS and formation of carotid plaque vulnerability.
Olfactory Dysfunction and its Course in Patients With Nasal Bone Fracture
Authors: Yoon Sihyun , Kim Youngjun
Published: August 2022

Purpose:

Nasal bone fractures are the most common facial bone fractures. Although olfactory dysfunction is one of the most common complications in patients with nasal bone fractures, few studies on olfactory dysfunction in nasal bone fractures have been reported. The authors attempted to find the frequency and course of olfactory dysfunction and hypothesize its mechanism in patients with nasal bone fractures.

Methods:

Sixty-six patients who underwent closed reduction were examined using the Korean version of Sniffin’ Sticks test (KVSS) II at preoperation, 1 month and 6 months postoperation. We categorized 30 points or more as “normosmia,” 15 points or less as “anosmia,” and the scores between them as “hyposmia.” The authors only performed test in patients who subjectively complained of their loss of sense of smell at 1 and 6 months postoperation.

Results:

The authors classified the patients as “olfactory dysfunction” or “normal olfaction” using the Threshold-Discrimination-Identification score and subjective complaint of symptom. Olfactory dysfunction was seen on 31 of 66 patients (46.9%) preoperatively. Twenty-four patients (36.3%) showed olfactory dysfunction at 1 month postoperation, and 4 patients (6.0%) showed olfactory dysfunction at 6 months postoperation. Twelve of the 35 patients (34.3%) with normosmia shown in the preoperation had new olfactory dysfunction after the surgery.

Conclusion:

Olfactory dysfunction is common complication in nasal bone fracture. However, this complication was recovered in most cases (93.9%). In addition, patients should receive explanations about the possibility of iatrogenic olfactory impairment after surgery, and a gentle maneuver is helpful for preventing iatrogenic damage.
Exploring Social Cognition Tests to Differentiate Frontotemporal Dementia from Depression
Authors: Lichtenstein Maya L. , Stewart Peter V. , Kirchner H. Lester , Finney Glen , Feldman Howard H.
Published: August 2022

Behavioral-variant frontotemporal dementia (bvFTD) is challenging to recognize, and often misdiagnosed as depression (DEP). Evidence suggests changes in social cognition (SoCog) precede general cognitive decline in bvFTD. Currently, there are no screening measures of social cognition. 17 bvFTD, 16 DEP, and 18 control participants underwent 6 SoCog tests measuring: emotion recognition; theory of mind; empathy; insight. We used χ2, Wilcoxon rank sum, Kruskal-Wallis tests to compare groups, with decision tree analysis to identify items that best differentiated bvFTD from DEP. bvFTD performed significantly worse on all SoCog tasks compared with other groups. Decision tree analysis yielded a 5-item test with ROC area under the curve of 0.973 (95% CI: 0.928, 1.0) for differentiating bvFTD versus depression. These results suggest that it may be feasible to develop a screening measure of social cognition.
Localized bulging of an inflated rubber tube with fixed ends
Authors: Guo Zhiming , Wang Shibin , Fu Yibin
Published: August 2022

When a rubber tube with free ends is inflated under volume control, the pressure will first reach a maximum and then decrease monotonically to approach a constant asymptote. The pressure maximum corresponds to the initiation of a localized bulge and is predicted by a bifurcation condition, whereas the asymptote is the Maxwell pressure corresponding to a ‘two-phase’ propagation state. By contrast, when the tube is first pre-stretched and then has its ends fixed during subsequent inflation, the pressure as a function of the bulge amplitude has both a maximum and a minimum, and the behaviour on the right ascending branch has previously not been fully understood. We show that for all values of the pre-stretch and tube length, the ascending branches all converge to a single curve that is dependent only on the ratio of the tube thickness to the outer radius. This curve represents the Maxwell state to be approached in each case (if Euler buckling or axisymmetric wrinkling does not occur first), but this state is pressure-dependent, in contrast to the free-ends case. We also demonstrate experimentally that localized bulging cannot occur when the pre-stretch is sufficiently large and investigate what strain-energy functions can predict this observed phenomenon.

This article is part of the theme issue ‘The Ogden model of rubber mechanics: Fifty years of impact on nonlinear elasticity’.
Mechanics of pressurized planar hyperelastic membranes
Authors: Selvadurai A. P. S.
Published: August 2022

The paper examines the mechanics of inflation of incompressible planar hyperelastic membranes that are rigidly fixed at their boundary and subjected to a uniform pressure. Strain energy functions characterized by the neo-Hookean, Mooney–Rivlin and the Ogden forms are used. Fixity is provided along either circular or elliptical boundaries. The computational results indicate that the strain energy function has a significant influence on the pressure versus inflated volume response of the deformed membrane. When the strain energy function corresponds to a Mooney–Rivlin form, the circular membrane displays no tendency to develop any instability. The equivalent circular membranes composed of both the neo-Hookean and Ogden-type strain energy functions developed an initial ‘
Wrinkling Instability
’. For planar membranes with an elliptical planform, the wrinkling instability is more pronounced; membranes composed of hyperelastic materials with a Mooney–Rivlin form of the strain energy function continue to deform without the development of an initial instability point, whereas membranes composed of both the neo-Hookean and Ogden materials exhibit wrinkling behaviour at critical locations at the interior of the fixed boundary region. The dependency of the strain energy function on the second invariant of the Cauchy–Green strain tensor has an influence in the suppression of hyperelastic effects.

This article is part of the theme issue 'The Ogden model of rubber mechanics: Fifty years of impact on nonlinear elasticity'.
A mathematical model for the auxetic response of liquid crystal elastomers
Authors: Mihai L. Angela , Mistry Devesh , Raistrick Thomas , Gleeson Helen F. , Goriely Alain
Published: August 2022

We develop a mathematical model that builds on the surprising nonlinear mechanical response observed in recent experiments on nematic liquid crystal elastomers. Namely, under uniaxial tensile loads, the material, rather than thinning in the perpendicular directions, becomes thicker in one direction for a sufficiently large strain, while its volume remains unchanged. Motivated by this unusual large-strain auxetic behaviour, we model the material using an Ogden-type strain-energy function and calibrate its parameters to available datasets. We show that Ogden strain-energy functions are particularly suitable for modelling nematic elastomers because of their mathematical simplicity and their clear formulation in terms of the principal stretches, which have a direct kinematic interpretation.

This article is part of the theme issue ‘The Ogden model of rubber mechanics: Fifty years of impact on nonlinear elasticity’.